                         SEQUENCE LISTING

<110>  The Broad Institute, Inc.
       Massachusetts Institute of Technology
       Zhang, Feng
       Altae-Tran, Han
       Kannan, Soumya
 
<120>  Novel Type VI CRISPR Enzymes and Systems

<130>  BROD-4860WP

<150>  US 62/903,604
<151>  2019-09-20

<150>  US 62/905,645
<151>  2019-09-25

<150>  US 62/967,408
<151>  2020-01-29

<150>  US 63/044,190
<151>  2020-06-25

<160>  6066  

<170>  PatentIn version 3.5

<210>  1
<211>  1222
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1

Met Arg Ile Thr Lys Val Lys Val Glu Ala Gly Lys Pro Asp Glu Asn 
1               5                   10                  15      


Lys Gly Lys Met Val Leu Ile His Arg Lys Ile Lys Gln Gly Asn Leu 
            20                  25                  30          


Ile Leu Glu Asp Phe Ser Lys Ser Glu Arg Thr Gly Thr Ser His Lys 
        35                  40                  45              


Glu Leu Pro Asp Cys Thr Lys Ser Val Leu Tyr Glu Tyr Lys Asn Glu 
    50                  55                  60                  


Ser Phe Glu Leu Ser Leu Ser Lys Gln Thr Ile Ala Gly Asp Lys Glu 
65                  70                  75                  80  


Leu Lys Thr Pro Arg Cys Lys Gln Cys Gln Asp Arg Thr Asp Cys Lys 
                85                  90                  95      


Ala Cys Lys Asp Arg Thr Lys Ala Ile Lys Glu Leu Arg Lys Lys Val 
            100                 105                 110         


Glu Gly Leu Ile Lys Glu Val Ile His Val Ala Val Glu Lys Gln Glu 
        115                 120                 125             


Lys Thr Glu Tyr Ser Ala Arg Phe Asn Thr Ala Thr Ser Glu Asp Asp 
    130                 135                 140                 


Met Arg Cys Cys Leu Lys Thr Lys Phe Gln Gly Ile Leu Arg Tyr Lys 
145                 150                 155                 160 


Ser Thr Thr Gly Glu Ser Phe Glu Leu Asn Leu Pro Lys Cys Leu Ala 
                165                 170                 175     


Ala Tyr Ser Gln Thr Lys Asp Ala Lys Thr Leu Thr Pro Tyr Arg Asp 
            180                 185                 190         


Trp Ile Asp Ser Tyr Leu Gln Lys Lys Arg Ser Phe Leu Glu Lys Ser 
        195                 200                 205             


Ile Leu Asn Asn Arg Ile Val Val Asn Cys Ser Asn Glu Asp Thr Glu 
    210                 215                 220                 


Gln Leu Ser Lys Arg Lys Gln Ala Leu His Leu Trp Ala Asn Glu Tyr 
225                 230                 235                 240 


Glu Thr Lys Lys Lys Ile Glu Leu Gly Thr Leu Cys Ser Lys Tyr Asn 
                245                 250                 255     


Ile Asn Ala Leu Ser Thr Ser Leu Asn Asn Lys Phe Asn Ser Leu Leu 
            260                 265                 270         


Gln Ser Gly Lys Gly Ile Lys Lys Ser Lys Phe Pro His Arg Gly Pro 
        275                 280                 285             


Asp Leu Val Asp Ala Asn Thr Asn Phe Glu Leu Lys Lys Glu Leu Gln 
    290                 295                 300                 


Leu His Gln Ser Ser Val Phe Gly Thr Lys Ala Thr Leu Val Ile Asn 
305                 310                 315                 320 


Asn Ile Phe Lys Glu Asn Arg Glu Asn Val Gln Leu Ala Ile Tyr Asn 
                325                 330                 335     


Leu Glu Val Val Lys Tyr Leu Glu His Tyr Phe Pro Ile Lys Arg Lys 
            340                 345                 350         


Lys Gln Leu Leu Thr Val Asp Gln Val Arg Tyr Tyr Leu Lys Glu Thr 
        355                 360                 365             


Thr Ile Arg Glu Arg Val Gln Met Gln Leu Glu Asn Ala Ile Arg Met 
    370                 375                 380                 


His Leu Leu Gln Gln Gly Lys Leu Glu Asn His Asn Leu Lys Glu Asp 
385                 390                 395                 400 


Val Asp Ser Asn Ala Leu Ser Val Ile Lys Arg Asp Glu Phe Phe Met 
                405                 410                 415     


Leu Asn Phe Val Glu Met Cys Ala Phe Ala Ala Asn Asn Ile Arg Asn 
            420                 425                 430         


Ile Ile Asp Lys Glu Gln Val Asn Asp Ile Leu Gly Lys Ser Asp Phe 
        435                 440                 445             


Glu Arg Ser Leu Ala Lys Gly Asn Phe Asp Glu Asn Arg Tyr Lys Leu 
    450                 455                 460                 


Phe Tyr Gly Val Asp Leu Lys Ser Asp Thr Ser His Ser Ala Phe Asp 
465                 470                 475                 480 


Ile Gln Ala Leu Trp Ala Met Arg Gly Ala Val Gln Gln Ile Arg Asn 
                485                 490                 495     


Glu Val Ile His Tyr His Thr Asp Thr Leu Asn Lys Ile Phe Lys Leu 
            500                 505                 510         


Asp Lys Phe Glu Tyr Lys Asp Asp Ala Asn Ala Glu Glu Cys Lys Tyr 
        515                 520                 525             


Thr Asn Thr Val Phe Gln Thr Leu Leu Glu Ser Ser Ile His Gln Leu 
    530                 535                 540                 


Asp Glu Tyr Phe Ile Glu Gln Leu Arg Ser Asn Asn Val Leu Ser Tyr 
545                 550                 555                 560 


Tyr Ala Leu Asp Ser Leu Asn His Leu Leu Gly Tyr Cys Thr Ile Ser 
                565                 570                 575     


Leu Arg Lys Ser Ser Ile Pro Phe Ala Pro Gly Phe Lys Asn Val Tyr 
            580                 585                 590         


Ala Leu Gly Ala Asn Leu Gln Tyr Gly Asn Thr Ser Met Asn Leu Lys 
        595                 600                 605             


Asn Tyr Leu Leu Lys Asp Glu Lys Gly Gln Ser Ile Asp Pro Thr Lys 
    610                 615                 620                 


Thr Lys Ser Ser His Ala Tyr Pro Ala Phe Arg Phe Ile Leu Lys Leu 
625                 630                 635                 640 


Val Tyr Asn His Ile Phe Leu Ser Arg Phe Leu Asp Asn Thr Gln Gln 
                645                 650                 655     


Asp Ala Phe Lys Glu Ala Val Thr Phe Val Leu Gln Asn Asn Arg Glu 
            660                 665                 670         


Glu Ala Ala Lys Ala Thr Lys Pro Thr Lys Gly Lys Pro Asn Phe His 
        675                 680                 685             


Ser His Gln Asp Lys Gln Glu Pro Glu Lys Tyr Ala Phe Lys Glu Ile 
    690                 695                 700                 


Arg Glu Met Gln Val Gly Glu Thr Ile Ser Ser Tyr Met Ser Tyr Ile 
705                 710                 715                 720 


Tyr Ser Tyr Ser Val Gln Glu Lys Glu Arg Lys Gly Asp Glu Asn Asp 
                725                 730                 735     


Asn Thr Arg His Asn Thr Asp Lys Phe Ile Glu Lys Val Phe Thr Lys 
            740                 745                 750         


Gly Phe Asp Ser Phe Leu Ser Thr Leu Pro Thr Ala Phe Leu Tyr Ser 
        755                 760                 765             


Pro Glu Asp Glu Gln Glu Val Glu Asn Glu Asp Tyr Gln Ala Leu Ala 
    770                 775                 780                 


Ile Gly Gln Gln Val Gln His Cys Ile Lys Ser Asp Asn Gly Thr His 
785                 790                 795                 800 


Ile Leu Phe Phe Thr Phe Cys Lys Leu Leu Asp Gly Asn His Leu Ser 
                805                 810                 815     


Asp Leu Arg Asn Glu Trp Leu Lys Tyr Tyr Ala Ser Asp Arg Thr Asp 
            820                 825                 830         


Ser Phe His Tyr Asp Phe Ala Leu Asp Ile Ile Glu Leu Cys Leu Leu 
        835                 840                 845             


Gly Lys Asp Lys Glu Ile Val Pro Thr Lys Glu Asp Ile Ile Cys Tyr 
    850                 855                 860                 


Ile Asn Thr Phe Val Glu Gly Asn Glu Lys Ser Asn Arg Ala Trp Thr 
865                 870                 875                 880 


Glu Phe Tyr Phe Gln Ser Asp Gln Asn Pro Val Glu Tyr Ala Ser Ile 
                885                 890                 895     


Asn Leu Leu Arg Lys His Gly Thr Leu Glu Leu Leu Lys Leu Ile Val 
            900                 905                 910         


Gly Asp Thr Tyr Lys Val Thr Gln Arg Asp Tyr Asp Glu Trp Lys Thr 
        915                 920                 925             


Leu Lys Glu Ser Ile Glu Asn Asp Val Asn Glu Arg Glu Ile Ile His 
    930                 935                 940                 


Lys Glu Trp Val Glu Leu Glu Asn Lys Arg Thr Glu Trp Tyr Lys Lys 
945                 950                 955                 960 


Asn Gly Arg Pro Ser Asn Lys Ala Glu Lys Asp Lys Ile Asn Arg Met 
                965                 970                 975     


Phe Gln Leu Pro Asp Ser Arg Leu Asn Lys Tyr Lys Glu Leu Cys Ile 
            980                 985                 990         


Arg Ile Glu Arg Tyr Asn Trp Leu  Asp Asn Lys Leu His  Leu Val His 
        995                 1000                 1005             


Leu Lys  Lys Leu His Asn Leu  Ile Val Gln Leu Leu  Ser Arg Met 
    1010                 1015                 1020             


Ala Arg  Phe Val Ala Leu Trp  Asp Arg Asp Phe Val  His Leu Asp 
    1025                 1030                 1035             


Ala Ser  Arg Thr Glu Asp Glu  Tyr Arg Leu Thr Ser  Phe Val Asn 
    1040                 1045                 1050             


Leu Arg  Asn Leu Lys Tyr Glu  Ala Asp Asn Lys Lys  Phe Met Asp 
    1055                 1060                 1065             


Asn Tyr  Gln Asp Ser Ile Tyr  Arg Lys Asp Gly Ser  Lys Ile Glu 
    1070                 1075                 1080             


Glu His  Asp Ile Pro Leu Ile  Lys Thr Cys Val Asn  Asn Ile Lys 
    1085                 1090                 1095             


Gln Pro  Leu Tyr Arg Glu Thr  Phe Phe Met Lys Asn  Asp Asn Ala 
    1100                 1105                 1110             


Phe Ser  Asp Arg Asn Phe Ile  Ala His Phe Asn Tyr  Ile Thr Lys 
    1115                 1120                 1125             


Ser Ala  Glu His Ser Met Val  Asp Leu Val Asn Arg  Leu Arg Met 
    1130                 1135                 1140             


Leu Met  Ala Tyr Asp Arg Lys  Leu Arg Asn Ala Val  Ser Lys Ser 
    1145                 1150                 1155             


Ile Ile  His Val Phe Glu Gln  Asn Gly Met Glu Leu  Lys Phe Lys 
    1160                 1165                 1170             


Cys Ile  Thr Arg Gly Glu Thr  Glu His Lys Leu Glu  Leu Glu Ser 
    1175                 1180                 1185             


Ile Lys  Ser Lys Lys Met Ser  Leu Leu Lys Gly Lys  Leu Glu Ile 
    1190                 1195                 1200             


Asp Gln  Val Ser Glu Glu Tyr  Cys Arg Leu Cys Lys  Arg Leu Leu 
    1205                 1210                 1215             


Glu Met  Lys Lys 
    1220         


<210>  2
<211>  1245
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2

Met Lys Ile Ser Lys Val Asn His Val Lys Thr Gly Val Ser Ala Lys 
1               5                   10                  15      


Pro Ala Ile Glu Gly Gly Met Leu Tyr Asp Tyr Pro Ser Lys Glu Gly 
            20                  25                  30          


Gly Ser Lys Asp Leu Arg Lys His Ile Glu Glu Val Asn Arg Lys Ala 
        35                  40                  45              


Gln Ile Leu Tyr Asn Val Phe Asn Gln Val Lys Glu Lys Asp Lys Lys 
    50                  55                  60                  


Gln Asn Ser Val Lys Asp Ala Leu Lys Ile Ala Asn Ala Tyr Ile Asn 
65                  70                  75                  80  


Ser Thr Val Ile Phe Gly Ile Lys Lys Glu Phe Pro Glu Asn Lys Ile 
                85                  90                  95      


Cys Asn Asn Phe Ser Tyr Ala Val Asn Arg Pro Ile Arg Leu Gly Lys 
            100                 105                 110         


Glu Asn Val Phe Ile Thr Ser Ile Ser Val Ser Val Lys Glu Lys Ser 
        115                 120                 125             


Ala Lys Glu Ser Ala Glu Tyr Ile Val Asn Asn Tyr Leu Arg Asn Ser 
    130                 135                 140                 


Leu Arg Arg Asp Lys Arg Ala Ala Glu Thr Ile Val Arg Ile Leu Thr 
145                 150                 155                 160 


Ala Leu Tyr Asp Gly Lys Asn Tyr Glu Lys Leu Ile Lys Lys Ile Glu 
                165                 170                 175     


Arg Glu Asp Leu Ala Ala Val Val Ser Ala Val Ser Arg Asp Tyr Leu 
            180                 185                 190         


Lys Asp Gly Glu Leu Glu Lys Ile Ala Val Ser Ile Glu Lys Gln Lys 
        195                 200                 205             


Val Leu Val Gln Val Gly Lys Asp Gly Tyr Leu Ile Pro Ser Gly Ala 
    210                 215                 220                 


Glu His Glu Lys Lys Ala Tyr Ile Phe Asn Phe Met Lys Lys Tyr Ala 
225                 230                 235                 240 


Glu Ser Asp Glu Glu Gly Gln Arg Lys Met Leu Asn His Met Lys Asp 
                245                 250                 255     


Leu Ile Arg Leu Tyr Tyr Thr Glu Glu Glu Val Val Ser Ser Glu Ile 
            260                 265                 270         


Leu Asp Leu Ile Asn Ser Arg Asp Asn Thr Pro Phe Ser Gln Lys Asp 
        275                 280                 285             


Ile Ile Arg Ser Tyr Asn Glu Gln Ile Ala Glu Lys Val Ser Ala Phe 
    290                 295                 300                 


Leu Val Glu Arg Tyr Gln Lys Thr Leu Lys Asp Ala Lys Ser Glu Asp 
305                 310                 315                 320 


Glu Glu Gly Trp Val Arg Tyr Ile Ser Asp Lys Ala Glu Lys Leu Leu 
                325                 330                 335     


Ser Val Lys Asn Leu Thr Gln Asp Arg Ile His Cys Asp Tyr Leu Phe 
            340                 345                 350         


Lys Lys Thr Trp Glu Glu Trp Thr Ser Phe Ile Ala Lys Lys Tyr Ile 
        355                 360                 365             


Asp Leu Gly Lys Ala Thr Tyr Asn Phe Ala Met Gly Asp Ile Ser Lys 
    370                 375                 380                 


Val Ser Lys Gly Glu Ser Val Ala Phe Gly Thr Val Asn Glu Gly Phe 
385                 390                 395                 400 


Glu Thr Gly Ile Ser Ser Phe Asp Tyr Glu Arg Met Lys Ala Glu Asp 
                405                 410                 415     


Ser Leu Asn Arg Ala Met Ile Lys Tyr Ile Ser Phe Ala Val Asn Ile 
            420                 425                 430         


Phe Asp Ala Ser Val Arg Asn Pro Glu Gln Arg Thr Gly Gly Lys Glu 
        435                 440                 445             


Asp Ile Leu Leu Leu Lys Pro Glu Asn Ile Val Met Tyr Glu Asp Ala 
    450                 455                 460                 


Val Lys Arg Val Leu Arg Tyr Phe Gly Gly Ile Ser Lys Phe Ser Glu 
465                 470                 475                 480 


Ser Ser Leu Asp Val Ser Asp Lys Asn Gly Phe Phe Thr Ala Leu Lys 
                485                 490                 495     


Asp Glu Leu Tyr Ala Ala Arg Asn Tyr Ala Phe His Tyr Val Thr Gly 
            500                 505                 510         


Glu Ala Glu Lys Arg Glu Lys Pro Val Val Thr Thr Leu Leu Asp Thr 
        515                 520                 525             


Glu Tyr Met Leu Val Gly Ser Ile Phe Arg Lys Lys Tyr Phe Ser Asn 
    530                 535                 540                 


Asn Val Pro Met Phe Tyr Arg Thr Ala Asp Ile Asp Asn Leu Met Ser 
545                 550                 555                 560 


Arg Leu Tyr Lys Ser Asn Arg Val Ile Leu Ala Gln Met Pro Ser Phe 
                565                 570                 575     


Asn Lys Val Leu Ser Arg Asn Ala Val Val Asp Phe Ala Asn Ala Tyr 
            580                 585                 590         


Leu Ala Gly Asp Ser Lys Arg Glu Met Ser Gln Pro Glu Ile Ser Glu 
        595                 600                 605             


Gln Phe Arg Ser Ser Phe Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Tyr 
    610                 615                 620                 


Asp Phe Ile Leu Lys Glu Asp Leu Leu Glu Arg Phe Lys Asn Gly Val 
625                 630                 635                 640 


Glu Cys Ala Gln Ala Ser Ala Ile Lys Lys Glu Asn Asn Ser Arg Lys 
                645                 650                 655     


His Val Ala Met Lys Asn Ala Tyr Arg Asp Phe Met Ser Arg Ala Asp 
            660                 665                 670         


Lys Leu Thr Lys Thr Lys Gly Ile Thr Phe Gly Gln Phe Cys Gln Glu 
        675                 680                 685             


Ile Met Thr Glu Tyr Asn Gln Gln Asn Ser Gln Lys Gln Lys Lys Pro 
    690                 695                 700                 


Ser Ala Val Glu Lys Thr Tyr Val Val Lys Gly Gln Thr Arg Thr Ser 
705                 710                 715                 720 


Val Arg Glu Val Glu Asp Lys Glu Gln Ile Tyr Lys His Tyr Arg Thr 
                725                 730                 735     


Leu Leu Tyr Ala Gly Ile Arg Glu Ala Phe Leu Ile Tyr Leu Lys Glu 
            740                 745                 750         


Glu Ala Ala Phe Gly Phe Leu Arg Ser Pro Lys Asp Gly Arg Glu Lys 
        755                 760                 765             


Phe Arg Asp Leu Lys Glu Glu Asp Phe Ser Gln Gly Trp Thr Thr Glu 
    770                 775                 780                 


Cys Tyr Thr Lys Leu Lys Asp Ala Ile Ile Glu Asp Lys Glu Leu Ser 
785                 790                 795                 800 


Ser Trp Tyr Val Thr Ala His Phe Met Asn Gln Lys His Leu Asn His 
                805                 810                 815     


Leu Ile Gly Glu Ile Lys Asn Tyr Val Gln Phe Ile Asp Asp Ile Glu 
            820                 825                 830         


Lys Arg Ala Lys Val Thr Gly Asn Arg Val Cys Ser Thr Glu Glu Lys 
        835                 840                 845             


Met Gly Lys Phe Thr Ser Leu Leu Glu Val Leu Glu Phe Cys Lys Leu 
    850                 855                 860                 


Phe Cys Gly Gln Val Ser Asn Asn Leu Glu Asp Tyr Phe Ala Asn Asn 
865                 870                 875                 880 


Glu Glu Tyr Ala Lys Tyr Val Ala Gly Phe Val Asp Tyr Gly Gly Thr 
                885                 890                 895     


Ser Ala Ala Leu Leu Gln Ala Phe Cys Arg Glu Asn Lys Glu Leu Asn 
            900                 905                 910         


Tyr Tyr Asp Glu Leu Asn Pro Ile Pro Asn Arg Asn Ile Ile Leu Ser 
        915                 920                 925             


Leu Leu Tyr Gly Asn Thr Ala Val Leu Ser Ser Ser Met Lys Lys Val 
    930                 935                 940                 


Thr Leu Gln Glu Val Lys Gly Tyr Gln Lys Asn Lys Glu Ser Leu Ser 
945                 950                 955                 960 


Gly Val Phe Lys Asn Gly Ala Cys Lys Asp Glu Asn Glu Gln Arg Lys 
                965                 970                 975     


Met Ser Asn Tyr Gln Lys Gln Lys Asn Arg Ile Glu Phe Val Asp Val 
            980                 985                 990         


Leu Thr Leu Thr Glu Leu Leu Asn  Asp Leu Tyr Gly Gln  Leu Ile Ser 
        995                 1000                 1005             


Tyr Ser  Tyr Leu Arg Glu Arg  Asp Leu Met Phe Met  Gln Leu Gly 
    1010                 1015                 1020             


Phe Tyr  Tyr Thr Lys Leu Phe  His Thr Ser Ser Val  Pro Ala Gln 
    1025                 1030                 1035             


Asp Lys  Leu Arg Val Leu Ser  Gly Asp Cys Asp Ile  Lys Asp Gly 
    1040                 1045                 1050             


Ala Val  Leu Tyr Gln Ile Ala  Ala Met Tyr Ser Tyr  Asp Leu Pro 
    1055                 1060                 1065             


Ile Tyr  Gly Ile Ser Lys Gln  Gly Val Ala Val Arg  Lys Lys Ser 
    1070                 1075                 1080             


Gly Val  Ser Thr Gly Ala Lys  Leu Asn Gln Phe Ser  Thr Glu Tyr 
    1085                 1090                 1095             


Cys Gly  Gly Lys Trp Asp Ile  Tyr Thr Asn Gly Leu  Tyr Phe Phe 
    1100                 1105                 1110             


Glu Asp  Val Asp Gly Arg His  Lys Asp Tyr Val Glu  Val Arg Asn 
    1115                 1120                 1125             


Tyr Ile  Glu His Phe Lys Tyr  Phe Ala Asp His Lys  Lys Ser Ile 
    1130                 1135                 1140             


Leu Asp  Leu Tyr Ser Asp Leu  Tyr Asn Gly Phe Phe  Ser Tyr Asp 
    1145                 1150                 1155             


Thr Lys  Leu Lys Lys Ser Met  Ser Phe Val Leu Pro  Asn Ile Leu 
    1160                 1165                 1170             


Leu Ser  His Phe Val Asn Ala  Lys Leu Ser Tyr Glu  Lys Asp Val 
    1175                 1180                 1185             


Val Gln  Lys Asn Ser Glu Ser  Tyr Arg Arg Ala Arg  Ile Val Ile 
    1190                 1195                 1200             


Arg Glu  Lys Asp Ile Lys Ser  Asp Phe Leu Thr Tyr  Lys Asn Lys 
    1205                 1210                 1215             


Glu Asn  Ser Lys Ala Phe Tyr  Val Pro Ala Arg Asn  Asp Val Phe 
    1220                 1225                 1230             


Leu Lys  Glu Val Leu Asp Met  Ile Ser Phe Lys Arg  
    1235                 1240                 1245 


<210>  3
<211>  1425
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3

Met Lys Leu Ser Lys Val Asp Arg Ile Arg Val Ala Val Gly Lys Thr 
1               5                   10                  15      


Gly Lys Thr Glu Asn Gly Asn Ser Gln Gly Arg Gly Val Leu Tyr Arg 
            20                  25                  30          


Ser Pro Lys Gly Asn Lys Thr Val Ala Val Asp Ala Val Val Glu Glu 
        35                  40                  45              


Arg Ile Arg Asn Ala Asn Arg Leu Tyr Ser Ala Phe Phe Arg Cys Ala 
    50                  55                  60                  


Tyr Pro Glu Glu Pro Glu Arg His Phe Glu Glu Ile Ile Lys Arg Met 
65                  70                  75                  80  


Ala Thr Gly Lys Lys Ser Gly Ala Gln Ile Leu Lys Glu Tyr Ile Gly 
                85                  90                  95      


Tyr Glu Gly Gln Lys Asn Arg Lys Pro Tyr Thr Phe Tyr Val Asn Lys 
            100                 105                 110         


Cys Ala Tyr Arg Pro Ala Gly Lys Glu Leu Gly Gln Val Leu Arg Leu 
        115                 120                 125             


Phe Val Lys Glu Arg Leu Gly Gln Asn Trp Gln Asn Pro Glu Ala Ala 
    130                 135                 140                 


Glu Ala Ala Val Ala Leu Leu Thr Cys Leu Cys Glu Gly Lys Thr Asn 
145                 150                 155                 160 


Arg Tyr Thr Glu Asn Thr Ala Asp Gly Pro Val Leu Thr Glu Leu Ser 
                165                 170                 175     


Glu Gln Thr Val Thr Gln Leu Glu Gln Val Ser Arg Leu Gly Gly Ser 
            180                 185                 190         


Ile Leu Val Pro Lys Thr Glu Arg Leu Glu Thr Ile Val Thr Val Ile 
        195                 200                 205             


Leu Arg Leu Thr Ala Glu Gln Cys Asn Thr Ser Leu Tyr Val Asn Gly 
    210                 215                 220                 


Gly Thr Lys Glu Ala Gln Asp Ala Asp Leu Glu Lys Gln Ile Ala Leu 
225                 230                 235                 240 


Leu Lys Ser Leu Gln Thr Lys Pro Leu Leu Leu Lys Glu Arg Phe Asp 
                245                 250                 255     


Lys Val Thr Lys Gln Thr Ile Arg Asp Glu Gln Lys Leu Ser Glu Phe 
            260                 265                 270         


Ser Tyr Lys Asp Ala Thr Lys Glu Arg Met Glu Ala Val Val Val Arg 
        275                 280                 285             


Met Arg Lys Thr Leu Lys Lys Gly Ala Ser Arg Glu Val Ala Val Glu 
    290                 295                 300                 


Leu Leu Gln Ala Leu Ala Gln Tyr Asp Gly Lys Thr Trp Asp Gly Trp 
305                 310                 315                 320 


Leu Thr Gln Met Leu Glu Thr Glu Ala Ser Lys Lys Lys Leu Lys Asp 
                325                 330                 335     


Phe Ile Leu Ala Val Asn Lys Asp Phe His His Phe His Val Ile Lys 
            340                 345                 350         


Ser Val Lys Asn Thr Ala Val Ala Val Ser His Ser Glu Asp Asn Thr 
        355                 360                 365             


Leu Gln Leu Ser Gly Ala Lys Lys Lys Thr Lys Gly Ala Met Gln Asp 
    370                 375                 380                 


Ala Leu Phe Ala Tyr Ala Gln Ser Glu Glu Ser Ser Asp Glu Thr Leu 
385                 390                 395                 400 


His Arg Ile Lys Arg Ile Leu Phe Thr Tyr Val Leu Gly Gly Arg Gln 
                405                 410                 415     


Asp Asn Thr Leu Arg Leu Thr Glu Lys Thr His Leu Ala Lys Glu Leu 
            420                 425                 430         


Leu Trp Lys Phe Arg Gly Thr Gly Ala Gly Leu Phe Asp Ala Asp Phe 
        435                 440                 445             


Val Pro Glu Glu Glu Arg Ala Gly Glu Ser Gly Arg Lys Ala Gly Ser 
    450                 455                 460                 


Tyr Thr Asp Leu Gly Cys Leu Phe Ala Glu Asp Asp Gly Ile Arg Asn 
465                 470                 475                 480 


Gln Arg Arg Ile Ala Asp Arg Ile Asn Tyr Val Asn Tyr Gly Asn Tyr 
                485                 490                 495     


Leu Arg Met Arg Lys Ala Ala Glu Asp Glu Phe Thr Leu Phe Trp Cys 
            500                 505                 510         


Ala Tyr Ile Lys Asp Tyr Ile Glu Glu Asn Tyr Val Thr Lys Ile Arg 
        515                 520                 525             


Glu Ala Lys Arg Thr Gly Gly Lys Arg Arg Leu Lys Glu Thr Asp Cys 
    530                 535                 540                 


Glu Ala Glu Arg Met Met Glu Lys Cys Trp His Asp Ile Ile Arg Tyr 
545                 550                 555                 560 


Ile Cys Gly Lys Tyr Ile His Ile Gly Lys Ala Val Tyr His Phe Ala 
                565                 570                 575     


Ile Pro Glu Asp Leu Leu Ala Asn Pro Gly Glu Val Arg Ser Phe Gly 
            580                 585                 590         


Asp Val His Ala Lys Tyr Ala Asp Gly Ile Thr Ser Phe Asp Tyr Glu 
        595                 600                 605             


Asp Ile Lys Ala Glu Glu Asn Leu Gln Lys Ser Ile Phe Asn Val Leu 
    610                 615                 620                 


Val Ser Ala Val Ala Asn Tyr Ser Arg Ser Val Val Asp Leu Ser Ser 
625                 630                 635                 640 


Glu Arg Ala Glu Glu Leu Arg Arg Leu Pro Gly Asn Glu Arg Leu Asn 
                645                 650                 655     


Glu Asp Val Leu Met Met Lys Glu Thr His Leu Lys Glu Leu Leu Leu 
            660                 665                 670         


Pro Asp Ala Lys Lys Arg Leu Leu Arg Tyr Phe Gly Gly Tyr Ser Ala 
        675                 680                 685             


Cys Glu Gly Leu Ser Gly Val Thr Ser Glu Glu Leu Ala Trp Glu Met 
    690                 695                 700                 


Arg Thr Val Leu Ser Thr Leu Arg Asn Glu Ser Phe His Tyr Thr Phe 
705                 710                 715                 720 


Gly Lys Lys Lys Lys Leu Asp Tyr Lys Val Ala Lys Gln Leu Trp Met 
                725                 730                 735     


Gln Ala Ile Arg Ala Asn Arg Gln Leu Ile Leu Asp Lys Tyr Tyr Ser 
            740                 745                 750         


Asn Asn Thr Cys Arg Tyr Tyr Ser Pro Asn Ser Ile Lys Ala Leu Ile 
        755                 760                 765             


Glu Gln Gly Tyr Arg Ser Tyr Glu Glu Arg Glu Ala Gln Ile Pro Ala 
    770                 775                 780                 


Phe Lys Thr Val Trp Lys Lys Ala Glu Leu Ala Lys Tyr Leu Ala Asp 
785                 790                 795                 800 


Lys Lys Val Met Pro Ala Glu Ile Ser Gly Glu Glu Lys Glu Arg Val 
                805                 810                 815     


Ile Phe Gln Gly Ala Phe Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg 
            820                 825                 830         


Glu Phe Thr Val Gly Asn Thr Ala Ala Lys Tyr Phe Phe Asp Ala Val 
        835                 840                 845             


Glu Arg Tyr Cys Lys Glu Asn Glu Thr Gly Pro Tyr Lys Asn Pro Ala 
    850                 855                 860                 


Lys Ser Phe Asn Asp Tyr Val Asn Gly Ala Phe Asn Asn Lys Gly Val 
865                 870                 875                 880 


Lys Val Gln Lys Gly Leu Ser Asp Leu Tyr Arg Glu Gly Lys Ile Thr 
                885                 890                 895     


Phe Gly Val Val Cys Gln Thr Ile Met Ala Glu Tyr Thr Gln Gln Asn 
            900                 905                 910         


Glu Lys Ser Glu Gly Glu Ala Ile Tyr Gln His Phe Lys Met Leu Phe 
        915                 920                 925             


Pro Leu Cys Met Arg Lys Gly Phe Gln Lys Tyr Val Glu Glu Lys His 
    930                 935                 940                 


Lys Glu Leu Leu Gln Pro Val Ile Arg Glu Met Gly Ser Arg Glu Asp 
945                 950                 955                 960 


Phe Leu Thr Asn Ile His Ile Gly Cys Phe Asp Asp Phe Cys Arg Glu 
                965                 970                 975     


Asp Gly Met Tyr Glu Tyr Asp Trp Phe Val Val Ala His Leu Ile His 
            980                 985                 990         


Pro Lys Arg Leu Asn Glu Leu Val  Gly Asn Leu Lys Asp  Tyr Met Gln 
        995                 1000                 1005             


Phe Lys  Gln Asp Ile Leu Arg  Arg Ala Asp Tyr Val  Glu Gln Phe 
    1010                 1015                 1020             


Thr Lys  Glu Glu Leu Ala Ala  Met Lys Ala Arg Thr  Glu Glu Lys 
    1025                 1030                 1035             


Leu Gln  Lys Ile Ser Gly Ile  Leu Arg Val Ala Glu  Phe Val Arg 
    1040                 1045                 1050             


Gly Ile  Ala Gly Arg Val Ser  Asn Thr Phe Ser Asp  Tyr Tyr Glu 
    1055                 1060                 1065             


Ser Glu  Glu Ala Tyr Ala Ser  Tyr Leu Glu Gln Tyr  Ile Glu Phe 
    1070                 1075                 1080             


Pro Arg  Ile Lys Gly Ser Thr  Val Phe Glu Ser Phe  Arg Asp Phe 
    1085                 1090                 1095             


Cys Val  Asn Thr Leu Pro Gly  Gly Ala Val Met Asp  Val Tyr Met 
    1100                 1105                 1110             


Asp Glu  Lys Asn Pro Arg Ile  Leu Arg Asn Val Glu  Val Ala Arg 
    1115                 1120                 1125             


Met Tyr  Ala Gly Gly Asp Ile  Gly Leu Arg Thr Arg  Lys Lys Val 
    1130                 1135                 1140             


Thr Ala  Glu Glu Leu Lys Arg  Tyr Tyr Gln Asn Glu  Ala Glu Val 
    1145                 1150                 1155             


Ala Ala  Leu Leu Lys Ala Gly  Leu Cys Ala Thr Ala  Glu Asp Gln 
    1160                 1165                 1170             


Lys Arg  Val Lys Ala Gln Gln  Glu Leu Arg Asn Arg  Ile Thr Leu 
    1175                 1180                 1185             


Thr Asp  Val Thr Glu Ile Gln  Glu Val Ile Asn Asp  Leu Leu Ser 
    1190                 1195                 1200             


Gln Leu  Val Thr Phe Ser Tyr  Phe Arg Glu Arg Asp  Glu Met Tyr 
    1205                 1210                 1215             


Leu Leu  Leu Gly Phe Tyr Tyr  Met Ala Leu Gln Ser  Asp Gly Asp 
    1220                 1225                 1230             


Trp Gly  Glu Glu Leu Arg Val  Phe Asp Gly Lys Lys  Leu Gln Val 
    1235                 1240                 1245             


Glu Asn  Gly Phe Val Leu Tyr  Gln Leu Leu Ser Ala  Phe Thr Tyr 
    1250                 1255                 1260             


Gly Leu  Asn Met Tyr Ser Glu  Ala Ala Pro Asp Gly  Lys Gly Gly 
    1265                 1270                 1275             


Ser Gln  Ala Gly Lys Ile Gly  Glu Phe Ile Lys Ala  His Pro Asn 
    1280                 1285                 1290             


Ser Trp  Asp Arg Ala Leu Arg  Leu Phe Val Asp Asp  Gly Ala Cys 
    1295                 1300                 1305             


Glu Glu  Val Ser Arg Lys Ala  Arg Asn Tyr Val Asp  His Phe Arg 
    1310                 1315                 1320             


Tyr Tyr  Val Lys Pro Asp Arg  Ser Ile Met Asp Leu  Tyr Ala Val 
    1325                 1330                 1335             


Tyr His  Glu Tyr Phe Phe Asp  Tyr Ser Thr Lys Met  Arg Lys Ser 
    1340                 1345                 1350             


Val Leu  Gln Asn Phe Ala Ser  Ile Leu Glu Arg Tyr  Phe Val Leu 
    1355                 1360                 1365             


Thr Lys  Phe Lys Leu Gly Gly  Glu Arg Gly Ala Gln  Thr Leu Glu 
    1370                 1375                 1380             


Ala Glu  Leu Ser Gly Asp Lys  Phe Thr Tyr Lys Leu  Ser Asp Thr 
    1385                 1390                 1395             


Lys Ala  Lys Pro Val Val Leu  Pro Ala Arg Asn Lys  Glu Phe Leu 
    1400                 1405                 1410             


Glu Asn  Leu Lys Asn Glu Leu  Asn Tyr Arg Gln Glu  
    1415                 1420                 1425 


<210>  4
<211>  1177
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  4

Leu Lys Val Ser Lys Val Asn Asn Val Arg Phe Ala Val Val Asn Lys 
1               5                   10                  15      


Ala Asp Asp Gln Lys Ser Glu His Met Gly Val Leu Tyr Lys Ser Pro 
            20                  25                  30          


Lys Asn Thr Ile Lys Thr Ser Asp Leu Arg Asn Val Val Lys Glu Arg 
        35                  40                  45              


Val Lys Lys Ala Ser Ile Lys Lys Lys Thr Ser Asp Asn Gly Pro Gln 
    50                  55                  60                  


Lys Arg Tyr Asp Ile Asp Ser Leu Thr Lys Ser Ile Lys Asn Gln Asn 
65                  70                  75                  80  


Leu Val Val Gln Thr Lys Thr Leu Glu Asn Asp Lys Asp Val Asn Asn 
                85                  90                  95      


Asn Asp Glu Ser Gly Glu Ser Thr His Ile Ile Gly Leu Ser Glu Arg 
            100                 105                 110         


Thr Gly Gly Ser Lys Ala Lys Leu Asp Lys Ala Phe Gly Asp Phe Leu 
        115                 120                 125             


Lys Glu Tyr Ala Thr Leu Asp Lys Glu Tyr Arg Lys Glu Cys Leu Asp 
    130                 135                 140                 


Lys Ile Arg Asn Ile Val Lys Tyr Phe Tyr Tyr Gly Gly Ser Ala Phe 
145                 150                 155                 160 


Tyr Gln Thr Glu Asp Lys Tyr Asp His Phe Val Val Leu Pro Glu Glu 
                165                 170                 175     


Leu Lys Lys Thr Gly Glu Asp Asn Asn Glu Asp Asn Val Lys Lys Ile 
            180                 185                 190         


Thr Gln Tyr Val Leu Arg Ile Ser Arg Lys Arg Tyr Asp Lys Cys Ile 
        195                 200                 205             


Val His Ile Val Lys Asn Lys Arg Asn Pro Gly Cys Phe Phe Asp Asn 
    210                 215                 220                 


Glu Asp Leu Asn Val Phe Trp Ile Arg His Ile Gln Ala Cys Phe Glu 
225                 230                 235                 240 


Asn Leu Leu Asn Asn Lys Ile Ala Lys Lys Gly Lys Tyr Tyr Arg Phe 
                245                 250                 255     


Asp Asp Lys Lys Leu Phe Asp Ala Thr Tyr Arg Glu Ala Ile Asn Tyr 
            260                 265                 270         


Leu Cys Val Lys Tyr Ile Ala Ile Gly Lys Met Val Tyr Lys Val Ile 
        275                 280                 285             


Asn Asp Arg Leu Ser Glu Asp Asp His Asn Thr Thr Asn Lys Lys Asp 
    290                 295                 300                 


Ile Asp Leu Ile Gly Val Asn Asp Arg Tyr Lys Asp Gly Phe Asp Ser 
305                 310                 315                 320 


Phe Met Leu Glu Asp Met Lys Ala Glu Glu Glu Leu Gln Arg Asn Ile 
                325                 330                 335     


Ser Val Tyr Cys Ser Phe Ala Ile Asn Asn Leu Arg Glu Ala Leu Asp 
            340                 345                 350         


Val Lys Gly Asp Ile Leu Phe Asp Lys Asn Lys Gly Ser Glu Asp Thr 
        355                 360                 365             


Glu Leu Asn Thr Thr Arg Ile Leu Gln Tyr Phe Gly Gly Lys Ser Arg 
    370                 375                 380                 


Trp Gln Lys Phe Phe Asp Met Ser Asp Met Asn Ala Asp Asp Leu Cys 
385                 390                 395                 400 


Lys Glu Val Lys Ser Ser Leu Ser Arg Leu Arg Asn Ser Ser Phe His 
                405                 410                 415     


Tyr Phe Thr Asn Glu Ser Lys Glu Asp Ser Asp Ala Leu Ser Thr Asn 
            420                 425                 430         


Thr Ile Ile Gly Glu Met Leu Lys Trp Asp Ala Lys Ala Ala Asp Met 
        435                 440                 445             


Gln Ile Val Glu Lys Ile Tyr Ser Asn Asn Leu Pro Met Phe Tyr Asn 
    450                 455                 460                 


Lys Glu Asp Leu Arg Glu Ala Ile Gly Thr Ile Tyr Ser Lys Thr Ser 
465                 470                 475                 480 


Glu Arg Lys Ser Gln Val Pro Ala Phe Asn Thr Val Ile Val Arg Lys 
                485                 490                 495     


Asn Leu Lys Ser Phe Leu Ala Asp Tyr Cys Asn Ile Pro Val Asp Lys 
            500                 505                 510         


Leu Leu Arg Glu Asn Lys Val Asp Glu Glu Met Gly Asn Lys Trp Leu 
        515                 520                 525             


Ser Ala Val Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Ser His Phe Leu 
    530                 535                 540                 


Arg Asp Ala Gly Cys Ile Asn Ser Lys Gly Ile Ser Tyr Thr Met Thr 
545                 550                 555                 560 


Leu Phe Asn Lys Asn Ile Ser Lys Leu Ser Asn Ala Ser Asn Asn Ser 
                565                 570                 575     


Trp Ala Val Asn Asp Phe Lys Glu Tyr Val Lys Ser Val Lys Glu Gly 
            580                 585                 590         


Arg Ser Leu Ser Glu Ile Cys Gln Met Ile Asn Thr Glu Tyr Glu Arg 
        595                 600                 605             


Gln Asn Asn Ser Ser Arg Lys Ile Lys Ser Ala Asp Gly Leu Ala Thr 
    610                 615                 620                 


Gly Lys Ile Pro Lys Asn Ala Phe Pro His Phe Lys Ile Phe Leu Asn 
625                 630                 635                 640 


Gln Thr Leu Met Gly Ala Phe Ser Asp Phe Leu Lys Ser Tyr Lys Lys 
                645                 650                 655     


Ser Lys Asp Ser Lys Lys Asn Ile Tyr Ser Phe Leu Ala Arg Pro Arg 
            660                 665                 670         


Phe Asn Lys Val Asn Pro Asp Lys Asp Glu Phe Ile Asn Phe Ile Leu 
        675                 680                 685             


Gly Gly Glu Gly Glu Asn Ala Phe Glu Tyr Tyr Ser Lys Asn Ser Glu 
    690                 695                 700                 


Val Leu Asn Asn Ile Ser Val Leu Glu Asp Trp Tyr Val Leu Gly Arg 
705                 710                 715                 720 


Met Leu Ser Pro Lys Cys Leu Asn Asn Leu Ser Gly Ser Leu Arg Arg 
                725                 730                 735     


Tyr Ile Gln Tyr Lys Thr Asp Ile Ser Asn Arg Lys Lys Thr Leu Lys 
            740                 745                 750         


Lys Tyr Asp Gly Glu Thr Glu Leu Glu Leu Gly Lys Ile Gly Arg Ile 
        755                 760                 765             


Lys Ile Val Leu Gly Ile Phe Asp Ile Cys Ser Arg Leu Ser Gly Ala 
    770                 775                 780                 


Val Ser Asn Asn Leu Lys Asp Tyr Phe Ala Asp Glu Glu Glu Tyr Ala 
785                 790                 795                 800 


Lys Phe Ile Tyr Lys Phe Phe Asp Tyr Gln Phe Asp Gly His Ser Tyr 
                805                 810                 815     


Ala Ser Ser Leu Asn Asn Phe Cys Asn Tyr Glu Asp Val Lys Arg Ile 
            820                 825                 830         


Gly Ile Tyr Tyr Asp Gly Asn Asn Pro Ile Ile Asn Lys Asn Ile Ile 
        835                 840                 845             


Leu Ala Lys Leu Tyr Gly Asn Ala Glu Lys Ile Ala Ala Val Leu Glu 
    850                 855                 860                 


Asn Asp Lys Val Asp Ile Asp Asp Ile Lys Ser Leu Asn Lys Ala Ala 
865                 870                 875                 880 


Gly Lys Leu Gln Ser Tyr Arg Leu Asn Gly Lys Val Lys Asn Asp Glu 
                885                 890                 895     


Glu Gln Asn Glu Leu Asn Arg Tyr Gln His Leu Lys Asn His Val Glu 
            900                 905                 910         


Phe Arg Asp Ile Val Asp Tyr Ala Glu Leu Ile Asn Asp Leu Gln Ala 
        915                 920                 925             


Asn Leu Ile Glu Trp Ala Cys Leu Arg Glu Arg Asp Leu Met Phe Phe 
    930                 935                 940                 


His Leu Gly Phe His Tyr Ser Val Leu Ser Lys Lys Arg Asp Val Pro 
945                 950                 955                 960 


Ala Glu Tyr Tyr Leu Leu Lys Asp Asn Gly Arg Tyr Ile Lys Gly Gly 
                965                 970                 975     


Ile Leu Tyr Gln Ile Phe Ala Met Tyr Ser Tyr Asp Met Glu Met Tyr 
            980                 985                 990         


Cys Gly Asp Ile Asp Lys Gln Gly  Asn Glu Lys Lys Lys  Lys Gly Ser 
        995                 1000                 1005             


Val Gly  Asn Lys Val Lys Leu  Phe Cys Thr Trp Ser  Gly Lys Leu 
    1010                 1015                 1020             


Thr Asn  Lys Arg Asn Asn Lys  Gly Tyr Tyr Asp Glu  Asp Ile Tyr 
    1025                 1030                 1035             


Thr Ala  Gly Leu Glu Leu Phe  Glu Met Ile Glu Asp  His Asp Lys 
    1040                 1045                 1050             


Tyr Ile  Glu Leu Arg Arg Phe  Ile Asp His Phe His  Tyr Tyr Tyr 
    1055                 1060                 1065             


Glu Glu  Thr Lys Ser Met Ile  Glu Leu Tyr Gly Glu  Val Phe Asp 
    1070                 1075                 1080             


Gly Phe  Phe Ser Tyr Asp Asn  Lys Leu Arg Lys Asn  Val Pro Val 
    1085                 1090                 1095             


Val Leu  Tyr Asn Ile Leu Met  Arg Tyr Leu Val Asn  Val Thr Phe 
    1100                 1105                 1110             


Arg Phe  Glu Asp Asp Pro Ala  Asn Gly Ile Ile Asn  Ile Arg Asn 
    1115                 1120                 1125             


Ala Lys  Ser Glu Lys Phe Thr  Tyr Leu Ile Asn Asn  Lys Lys Arg 
    1130                 1135                 1140             


Leu Leu  Tyr Ala Arg Gln Lys  Glu Tyr Ile Leu Asn  Val Leu Arg 
    1145                 1150                 1155             


Met Leu  Tyr Tyr Pro Phe Ile  Pro Glu Asp Leu Lys  Lys Arg Ile 
    1160                 1165                 1170             


Lys Val  Lys Asp 
    1175         


<210>  5
<211>  962
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (943)..(946)
<223>  Xaa can be any naturally occurring amino acid

<400>  5

Met Lys Val Thr Lys Ile Asp Gly Leu Ser His Lys Lys Phe Glu Val 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Phe Arg Asp Asn Lys Asn Ile Asn Glu Met 
            20                  25                  30          


Lys Glu Arg Leu Lys Lys Leu Lys Glu Leu Lys Leu Asp Asn Tyr Ile 
        35                  40                  45              


Lys Asn Pro Glu Asn Val Lys Asn Lys Asp Lys Asp Ala Glu Lys Glu 
    50                  55                  60                  


Thr Lys Lys Arg Arg Thr Asn Leu Lys Lys Tyr Phe Ser Glu Ile Ile 
65                  70                  75                  80  


Leu Arg Lys Glu Asp Glu Lys Tyr Ile Leu Lys Lys Thr Lys Lys Phe 
                85                  90                  95      


Lys Asn Ile Asn Gln Glu Ile Asp Tyr Tyr Asp Val Lys Ser Lys Lys 
            100                 105                 110         


Asn Gln Gln Glu Ile Phe Asp Val Leu Lys Glu Ile Lys Ile Lys Glu 
        115                 120                 125             


Thr Glu Lys Glu Glu Ile Ile Thr Phe Asp Ser Glu Lys Leu Lys Lys 
    130                 135                 140                 


Val Phe Gly Glu Asp Phe Val Lys Lys Glu Ala Lys Ile Lys Ala Ile 
145                 150                 155                 160 


Glu Lys Ser Leu Lys Ile Asn Lys Ala Asn Tyr Lys Lys Asp Ser Ile 
                165                 170                 175     


Lys Ile Gly Asp Asp Lys Tyr Ser Asn Val Lys Gly Glu Asn Lys Arg 
            180                 185                 190         


Ser Arg Ile Tyr Glu Tyr Tyr Lys Lys Ser Glu Asn Leu Lys Lys Phe 
        195                 200                 205             


Glu Glu Asn Ile Arg Glu Ala Phe Glu Lys Leu Tyr Thr Glu Glu Asn 
    210                 215                 220                 


Ile Lys Glu Leu Tyr Ser Lys Ile Glu Glu Val Leu Lys Lys Thr His 
225                 230                 235                 240 


Leu Lys Ser Ile Val Arg Glu Phe Tyr Gln Asn Glu Ile Ile Gly Glu 
                245                 250                 255     


Ser Glu Phe Ser Lys Lys Asn Gly Asp Gly Ile Ser Ile Leu Tyr Asn 
            260                 265                 270         


Gln Ile Lys Asp Ser Ile Lys Lys Glu Glu Asn Phe Ile Glu Phe Ile 
        275                 280                 285             


Glu Asn Ile Gly Asn Leu Glu Leu Lys Asp Leu Thr Lys Ser Gln Ile 
    290                 295                 300                 


Phe Tyr Lys Tyr Phe Leu Glu Asn Glu Glu Leu Asn Asp Glu Asn Ile 
305                 310                 315                 320 


Lys Phe Ala Phe Cys Tyr Phe Val Glu Ile Glu Val Asn Asn Leu Leu 
                325                 330                 335     


Lys Glu Asn Val Tyr Lys Ile Lys Arg Phe Asn Glu Gly Asn Lys Lys 
            340                 345                 350         


Arg Ile Lys Asn Ile Phe Glu Tyr Gly Lys Leu Lys Lys Leu Ile Val 
        355                 360                 365             


Tyr Lys Leu Glu Asn Lys Leu Asn Asn Tyr Val Arg Asn Cys Gly Lys 
    370                 375                 380                 


Tyr Asn Tyr His Met Glu Asn Gly Asp Ile Ala Thr Ser Asp Ile Asn 
385                 390                 395                 400 


Met Arg Asn Arg Gln Thr Glu Ala Phe Leu Arg Ser Ile Ile Gly Val 
                405                 410                 415     


Ser Ser Phe Gly Tyr Phe Ser Leu Arg Asn Ile Leu Gly Val Asn Asp 
            420                 425                 430         


Asp Asp Phe Tyr Glu Ile Glu Glu Gly Leu Thr Glu Glu Glu Arg Lys 
        435                 440                 445             


Asn Glu Ser Asn Val Leu Lys Lys Ala Lys Glu Asp Ile Thr Ser Lys 
    450                 455                 460                 


Ser Ile Phe Glu Lys Val Val Asp Lys Ser Phe Glu Lys Lys Gly Ile 
465                 470                 475                 480 


Arg Ser Ile Lys Glu Asn Leu Lys Met Phe Tyr Gly Asp Ser Phe Asp 
                485                 490                 495     


Lys Ala Asn Gly Asp Glu Leu Lys Gln Phe Phe Val Asn Met Leu Asn 
            500                 505                 510         


Ala Ile Thr Ser Ile Arg His Ser Val Val His Tyr Asp Met Asn Thr 
        515                 520                 525             


Asn Ser Glu Asn Ile Phe Asn Phe Ser Asp Ile Glu Val Ser Arg Leu 
    530                 535                 540                 


Leu Lys Ser Ile Phe Glu Lys Glu Thr Asp Lys Arg Glu Leu Lys Leu 
545                 550                 555                 560 


Lys Ile Phe Arg Gln Leu Asn Ser Ala Gly Val Phe Asp Tyr Trp Glu 
                565                 570                 575     


Asn Trp Lys Ile Lys Lys Tyr Leu Glu Asn Ile Lys Phe Glu Phe Val 
            580                 585                 590         


Asn Lys Asn Val Pro Phe Val Pro Ser Phe Thr Lys Leu Tyr Asn Arg 
        595                 600                 605             


Ile Asp Asn Leu Lys Gly Ser Asn Ala Leu Asn Leu Gly Tyr Ile Asn 
    610                 615                 620                 


Ile Pro Lys Arg Lys Glu Ala Arg Asp Ser Gln Ile Tyr Leu Leu Lys 
625                 630                 635                 640 


Asn Ile Tyr Tyr Gly Glu Phe Val Glu Glu Phe Ile Lys Asn Asn Asp 
                645                 650                 655     


Asn Phe Glu Lys Ile Phe Arg Glu Ile Ile Glu Ile Asn Lys Asn Ala 
            660                 665                 670         


Gly Arg Asn Lys Gln Thr Asn Phe Tyr Lys Leu Glu Lys Phe Glu Lys 
        675                 680                 685             


Leu Lys Ala Asn Thr Pro Thr Glu Tyr Leu Glu Lys Leu Gln Ser Leu 
    690                 695                 700                 


His Lys Ile Asn Tyr Asp Arg Glu Lys Ile Glu Glu Asp Lys Asp Ile 
705                 710                 715                 720 


Tyr Val Asp Phe Val Gln Lys Ile Phe Leu Lys Gly Phe Ile Asn Tyr 
                725                 730                 735     


Leu Gln Lys Ser Asn Ser Leu Lys Pro Leu Asn Leu Leu Asn Leu Lys 
            740                 745                 750         


Lys Asp Glu Ala Val Ala Asn Lys Lys Ser Phe Tyr Asp Glu Lys Leu 
        755                 760                 765             


Lys Gln Trp Glu Asn Asn Gly Ser Asn Leu Ser Glu Met Pro Lys Glu 
    770                 775                 780                 


Ile Tyr Lys Tyr Ile Lys Glu Ile Asn Ile Asn Lys Ile Asn Tyr Ser 
785                 790                 795                 800 


Asn Arg Met Ser Ile Phe Tyr Leu Leu Leu Lys Leu Ile Asp His Arg 
                805                 810                 815     


Glu Leu Thr Asn Leu Arg Gly Asn Leu Glu Lys Tyr Glu Ser Met Asn 
            820                 825                 830         


Lys Asn Lys Ile Tyr Ser Glu Glu Leu Asn Ile Val Asn Leu Val Ser 
        835                 840                 845             


Leu Asp Asn Asn Lys Val Arg Thr Asn Phe Ser Val Glu Ala Glu Asp 
    850                 855                 860                 


Ile Gly Lys Phe Leu Lys Thr Glu Thr Ser Ile Lys Asn Asn Lys Gln 
865                 870                 875                 880 


Leu Asn Asn Phe Ser Glu Ile Phe Ala Asp Gly Glu Asn Val Ile Lys 
                885                 890                 895     


His Arg Ser Phe Tyr Asn Ile Lys Lys Tyr Gly Ile Leu Asp Leu Leu 
            900                 905                 910         


Glu Lys Ile Val Thr Lys Ala Asp Leu Lys Ile Thr Lys Glu Glu Ile 
        915                 920                 925             


Lys Lys Tyr Lys Asn Leu Gln Lys Glu Leu Glu Lys Asn Asp Xaa Xaa 
    930                 935                 940                 


Xaa Xaa Ile Lys Phe Arg Lys Arg Phe Ile Glu Asn Ile Ile Lys Asn 
945                 950                 955                 960 


Gln Ile 
        


<210>  6
<211>  1425
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  6

Met Lys Leu Ser Lys Val Asp Arg Ile Arg Val Ala Val Gly Lys Thr 
1               5                   10                  15      


Gly Lys Thr Glu Asn Gly Asn Ser Gln Gly Arg Gly Val Leu Tyr Arg 
            20                  25                  30          


Ser Pro Lys Gly Asn Lys Thr Val Ala Val Asp Ala Val Val Glu Glu 
        35                  40                  45              


Arg Ile Arg Asn Ala Asn Arg Leu Tyr Ser Ala Phe Phe Arg Cys Ala 
    50                  55                  60                  


Tyr Pro Glu Glu Pro Glu Arg His Phe Glu Glu Ile Ile Lys Arg Met 
65                  70                  75                  80  


Ala Thr Gly Lys Lys Ser Gly Ala Gln Ile Leu Lys Glu Tyr Ile Gly 
                85                  90                  95      


Tyr Glu Gly Gln Lys Asn Arg Lys Pro Tyr Thr Phe Tyr Val Asn Lys 
            100                 105                 110         


Cys Ala Tyr Arg Pro Ala Gly Lys Glu Leu Gly Gln Val Leu Arg Leu 
        115                 120                 125             


Phe Val Lys Glu Arg Leu Gly Gln Asn Trp Gln Asn Pro Glu Ala Ala 
    130                 135                 140                 


Glu Ala Ala Val Ala Leu Leu Thr Cys Leu Cys Glu Gly Lys Thr Asn 
145                 150                 155                 160 


Arg Tyr Thr Glu Asn Thr Ala Asp Gly Pro Val Leu Thr Glu Leu Ser 
                165                 170                 175     


Glu Gln Thr Val Thr Gln Leu Glu Gln Val Ser Arg Leu Gly Gly Ser 
            180                 185                 190         


Ile Leu Val Pro Lys Thr Glu Arg Leu Glu Thr Ile Val Thr Val Ile 
        195                 200                 205             


Leu Arg Leu Thr Ala Glu Gln Cys Asn Thr Ser Leu Tyr Val Asn Gly 
    210                 215                 220                 


Gly Thr Lys Glu Ala Gln Asp Ala Asp Leu Glu Lys Gln Ile Ala Leu 
225                 230                 235                 240 


Leu Lys Ser Leu Gln Thr Lys Pro Leu Leu Leu Lys Glu Arg Phe Asp 
                245                 250                 255     


Lys Val Thr Lys Gln Thr Ile Arg Asp Glu Gln Lys Leu Ser Glu Phe 
            260                 265                 270         


Ser Tyr Lys Asp Ala Thr Lys Glu Arg Met Glu Ala Val Val Val Arg 
        275                 280                 285             


Met Arg Lys Thr Leu Lys Lys Gly Ala Ser Arg Glu Val Ala Val Glu 
    290                 295                 300                 


Leu Leu Gln Ala Leu Ala Gln Tyr Asp Gly Lys Thr Trp Asp Gly Trp 
305                 310                 315                 320 


Leu Thr Gln Met Leu Glu Thr Glu Ala Ser Lys Lys Lys Leu Lys Asp 
                325                 330                 335     


Phe Ile Leu Ala Val Asn Lys Asp Phe His His Phe His Val Ile Lys 
            340                 345                 350         


Ser Val Lys Asn Thr Ala Val Ala Val Ser His Ser Glu Asp Asn Thr 
        355                 360                 365             


Leu Gln Leu Ser Gly Ala Lys Lys Lys Thr Lys Gly Ala Met Gln Asp 
    370                 375                 380                 


Ala Leu Phe Ala Tyr Ala Gln Ser Glu Glu Ser Ser Asp Glu Thr Leu 
385                 390                 395                 400 


His Arg Ile Lys Arg Ile Leu Phe Thr Tyr Val Leu Gly Gly Arg Gln 
                405                 410                 415     


Asp Asn Thr Leu Arg Leu Thr Glu Lys Thr His Leu Ala Lys Glu Leu 
            420                 425                 430         


Leu Trp Lys Phe Arg Gly Thr Gly Ala Gly Leu Phe Asp Ala Asp Phe 
        435                 440                 445             


Val Pro Glu Glu Glu Arg Ala Gly Glu Ser Gly Arg Lys Ala Gly Ser 
    450                 455                 460                 


Tyr Thr Asp Leu Gly Cys Leu Phe Ala Glu Asp Asp Gly Ile Arg Asn 
465                 470                 475                 480 


Gln Arg Arg Ile Ala Asp Arg Ile Asn Tyr Val Asn Tyr Gly Asn Tyr 
                485                 490                 495     


Leu Arg Met Arg Lys Ala Ala Glu Asp Glu Phe Thr Leu Phe Trp Cys 
            500                 505                 510         


Ala Tyr Ile Lys Asp Tyr Ile Glu Glu Asn Tyr Val Thr Lys Ile Arg 
        515                 520                 525             


Glu Ala Lys Arg Thr Gly Gly Lys Arg Arg Leu Lys Glu Thr Asp Cys 
    530                 535                 540                 


Glu Ala Glu Arg Met Met Glu Lys Cys Trp His Asp Ile Ile Arg Tyr 
545                 550                 555                 560 


Ile Cys Gly Lys Tyr Ile His Ile Gly Lys Ala Val Tyr His Phe Ala 
                565                 570                 575     


Ile Pro Glu Asp Leu Leu Ala Asn Pro Gly Glu Val Arg Ser Phe Gly 
            580                 585                 590         


Asp Val His Ala Lys Tyr Ala Asp Gly Ile Thr Ser Phe Asp Tyr Glu 
        595                 600                 605             


Asp Ile Lys Ala Glu Glu Asn Leu Gln Lys Ser Ile Phe Asn Val Leu 
    610                 615                 620                 


Val Ser Ala Val Ala Asn Tyr Ser Arg Ser Val Val Asp Leu Ser Ser 
625                 630                 635                 640 


Glu Arg Ala Glu Glu Leu Arg Arg Leu Pro Gly Asn Glu Arg Leu Asn 
                645                 650                 655     


Glu Asp Val Leu Met Met Lys Glu Thr His Leu Lys Glu Leu Leu Leu 
            660                 665                 670         


Pro Asp Ala Lys Lys Arg Leu Leu Arg Tyr Phe Gly Gly Tyr Ser Ala 
        675                 680                 685             


Cys Glu Gly Leu Ser Gly Val Thr Ser Glu Glu Leu Ala Trp Glu Met 
    690                 695                 700                 


Arg Thr Val Leu Ser Thr Leu Arg Asn Glu Ser Phe His Tyr Thr Phe 
705                 710                 715                 720 


Gly Lys Lys Lys Lys Leu Asp Tyr Lys Val Ala Lys Gln Leu Trp Met 
                725                 730                 735     


Gln Ala Ile Arg Ala Asn Arg Gln Leu Ile Leu Asp Lys Tyr Tyr Ser 
            740                 745                 750         


Asn Asn Thr Cys Arg Tyr Tyr Ser Pro Asn Ser Ile Lys Ala Leu Ile 
        755                 760                 765             


Glu Gln Gly Tyr Arg Ser Tyr Glu Glu Arg Glu Ala Gln Ile Pro Ala 
    770                 775                 780                 


Phe Lys Thr Val Trp Lys Lys Ala Glu Leu Ala Lys Tyr Leu Ala Asp 
785                 790                 795                 800 


Lys Lys Val Met Pro Ala Glu Ile Ser Gly Glu Glu Lys Glu Arg Val 
                805                 810                 815     


Ile Phe Gln Gly Ala Phe Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg 
            820                 825                 830         


Glu Phe Thr Val Gly Asn Thr Ala Ala Lys Tyr Phe Phe Asp Ala Val 
        835                 840                 845             


Glu Arg Tyr Cys Lys Glu Asn Glu Thr Gly Pro Tyr Lys Asn Pro Ala 
    850                 855                 860                 


Lys Ser Phe Asn Asp Tyr Val Asn Gly Ala Phe Asn Asn Lys Gly Val 
865                 870                 875                 880 


Lys Val Gln Lys Gly Leu Ser Asp Leu Tyr Arg Glu Gly Lys Ile Thr 
                885                 890                 895     


Phe Gly Val Val Cys Gln Thr Ile Met Ala Glu Tyr Thr Gln Gln Asn 
            900                 905                 910         


Glu Lys Ser Glu Gly Glu Ala Ile Tyr Gln His Phe Lys Met Leu Phe 
        915                 920                 925             


Pro Leu Cys Met Arg Lys Gly Phe Gln Lys Tyr Val Glu Glu Lys His 
    930                 935                 940                 


Lys Glu Leu Leu Gln Pro Val Ile Arg Glu Met Gly Ser Arg Glu Asp 
945                 950                 955                 960 


Phe Leu Thr Asn Ile His Ile Gly Cys Phe Asp Asp Phe Cys Arg Glu 
                965                 970                 975     


Asp Gly Met Tyr Glu Tyr Asp Trp Phe Val Val Ala His Leu Ile His 
            980                 985                 990         


Pro Lys Arg Leu Asn Glu Leu Val  Gly Asn Leu Lys Asp  Tyr Met Gln 
        995                 1000                 1005             


Phe Lys  Gln Asp Ile Leu Arg  Arg Ala Asp Tyr Val  Glu Gln Phe 
    1010                 1015                 1020             


Thr Lys  Glu Glu Leu Ala Ala  Met Lys Ala Arg Thr  Glu Glu Lys 
    1025                 1030                 1035             


Leu Gln  Lys Ile Ser Gly Ile  Leu Arg Val Ala Glu  Phe Val Arg 
    1040                 1045                 1050             


Gly Ile  Ala Gly Arg Val Ser  Asn Thr Phe Ser Asp  Tyr Tyr Glu 
    1055                 1060                 1065             


Ser Glu  Glu Ala Tyr Ala Ser  Tyr Leu Glu Gln Tyr  Ile Glu Phe 
    1070                 1075                 1080             


Pro Arg  Ile Lys Gly Ser Thr  Val Phe Glu Ser Phe  Arg Asp Phe 
    1085                 1090                 1095             


Cys Val  Asn Thr Leu Pro Gly  Gly Ala Val Met Asp  Val Tyr Met 
    1100                 1105                 1110             


Asp Glu  Lys Asn Pro Arg Ile  Leu Arg Asn Val Glu  Val Ala Arg 
    1115                 1120                 1125             


Met Tyr  Ala Gly Gly Asp Ile  Gly Leu Arg Thr Arg  Lys Lys Val 
    1130                 1135                 1140             


Thr Ala  Glu Glu Leu Lys Arg  Tyr Tyr Gln Asn Glu  Ala Glu Val 
    1145                 1150                 1155             


Ala Ala  Leu Leu Lys Ala Gly  Leu Cys Ala Thr Ala  Glu Asp Gln 
    1160                 1165                 1170             


Lys Arg  Val Lys Ala Gln Gln  Glu Leu Arg Asn Arg  Ile Thr Leu 
    1175                 1180                 1185             


Thr Asp  Val Thr Glu Ile Gln  Glu Val Ile Asn Asp  Leu Leu Ser 
    1190                 1195                 1200             


Gln Leu  Val Thr Phe Ser Tyr  Phe Arg Glu Arg Asp  Glu Met Tyr 
    1205                 1210                 1215             


Leu Leu  Leu Gly Phe Tyr Tyr  Met Ala Leu Gln Ser  Asp Gly Asp 
    1220                 1225                 1230             


Trp Gly  Glu Glu Leu Arg Val  Phe Asp Gly Lys Lys  Leu Gln Val 
    1235                 1240                 1245             


Glu Asn  Gly Phe Val Leu Tyr  Gln Leu Leu Ser Ala  Phe Thr Tyr 
    1250                 1255                 1260             


Gly Leu  Asn Met Tyr Ser Glu  Ala Ala Pro Asp Gly  Lys Gly Gly 
    1265                 1270                 1275             


Ser Gln  Ala Gly Lys Ile Gly  Glu Phe Ile Lys Ala  His Pro Asn 
    1280                 1285                 1290             


Ser Trp  Asp Arg Ala Leu Arg  Leu Phe Val Asp Asp  Gly Ala Cys 
    1295                 1300                 1305             


Glu Glu  Val Ser Arg Lys Ala  Arg Asn Tyr Val Asp  His Phe Arg 
    1310                 1315                 1320             


Tyr Tyr  Val Lys Pro Asp Arg  Ser Ile Met Asp Leu  Tyr Ala Val 
    1325                 1330                 1335             


Tyr His  Glu Tyr Phe Phe Asp  Tyr Ser Thr Lys Met  Arg Lys Ser 
    1340                 1345                 1350             


Val Leu  Gln Asn Phe Ala Ser  Ile Leu Glu Arg Tyr  Phe Val Leu 
    1355                 1360                 1365             


Thr Lys  Phe Lys Leu Gly Gly  Glu Arg Gly Ala Gln  Thr Leu Glu 
    1370                 1375                 1380             


Ala Glu  Leu Ser Gly Asp Lys  Phe Thr Tyr Lys Leu  Ser Asp Thr 
    1385                 1390                 1395             


Lys Ala  Lys Pro Val Val Leu  Pro Ala Arg Asn Lys  Glu Phe Leu 
    1400                 1405                 1410             


Glu Asn  Leu Lys Asn Glu Leu  Asn Tyr Arg Gln Glu  
    1415                 1420                 1425 


<210>  7
<211>  1222
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  7

Met Arg Ile Thr Lys Val Lys Val Glu Ala Gly Lys Pro Asp Glu Asn 
1               5                   10                  15      


Lys Gly Lys Met Val Leu Ile His Arg Lys Ile Lys Gln Gly Asn Leu 
            20                  25                  30          


Ile Leu Glu Asp Phe Ser Lys Ser Glu Arg Thr Gly Thr Ser His Lys 
        35                  40                  45              


Glu Leu Pro Asp Cys Thr Lys Ser Val Leu Tyr Glu Tyr Lys Asn Glu 
    50                  55                  60                  


Ser Phe Glu Leu Ser Leu Ser Lys Gln Thr Ile Ala Gly Asp Lys Glu 
65                  70                  75                  80  


Leu Lys Thr Pro Arg Cys Lys Gln Cys Gln Asp Arg Thr Asp Cys Lys 
                85                  90                  95      


Ala Cys Lys Asp Arg Thr Lys Ala Ile Lys Glu Leu Arg Lys Lys Val 
            100                 105                 110         


Glu Gly Leu Ile Lys Glu Val Ile His Val Ala Val Glu Lys Gln Glu 
        115                 120                 125             


Lys Thr Glu Tyr Ser Ala Arg Phe Asn Thr Ala Thr Ser Glu Asp Asp 
    130                 135                 140                 


Met Arg Cys Cys Leu Lys Thr Lys Phe Gln Gly Ile Leu Arg Tyr Lys 
145                 150                 155                 160 


Ser Thr Thr Gly Glu Ser Phe Glu Leu Asn Leu Pro Lys Cys Leu Ala 
                165                 170                 175     


Ala Tyr Ser Gln Thr Lys Asp Ala Lys Thr Leu Thr Pro Tyr Arg Asp 
            180                 185                 190         


Trp Ile Asp Ser Tyr Leu Gln Lys Lys Arg Ser Phe Leu Glu Lys Ser 
        195                 200                 205             


Ile Leu Asn Asn Arg Ile Val Val Asn Cys Ser Asn Glu Asp Thr Glu 
    210                 215                 220                 


Gln Leu Ser Lys Arg Lys Gln Ala Leu His Leu Trp Ala Asn Glu Tyr 
225                 230                 235                 240 


Glu Thr Lys Lys Lys Ile Glu Leu Gly Thr Leu Cys Ser Lys Tyr Asn 
                245                 250                 255     


Ile Asn Ala Leu Ser Thr Ser Leu Asn Asn Lys Phe Asn Ser Leu Leu 
            260                 265                 270         


Gln Ser Gly Lys Gly Ile Lys Lys Ser Lys Phe Pro His Arg Gly Pro 
        275                 280                 285             


Asp Leu Val Asp Ala Asn Thr Asn Phe Glu Leu Lys Lys Glu Leu Gln 
    290                 295                 300                 


Leu His Gln Ser Ser Val Phe Gly Thr Lys Ala Thr Leu Val Ile Asn 
305                 310                 315                 320 


Asn Ile Phe Lys Glu Asn Arg Glu Asn Val Gln Leu Ala Ile Tyr Asn 
                325                 330                 335     


Leu Glu Val Val Lys Tyr Leu Glu His Tyr Phe Pro Ile Lys Arg Lys 
            340                 345                 350         


Lys Gln Leu Leu Thr Val Asp Gln Val Arg Tyr Tyr Leu Lys Glu Thr 
        355                 360                 365             


Thr Ile Arg Glu Arg Val Gln Met Gln Leu Glu Asn Ala Ile Arg Met 
    370                 375                 380                 


His Leu Leu Gln Gln Gly Lys Leu Glu Asn His Asn Leu Lys Glu Asp 
385                 390                 395                 400 


Val Asp Ser Asn Ala Leu Ser Val Ile Lys Arg Asp Glu Phe Phe Met 
                405                 410                 415     


Leu Asn Phe Val Glu Met Cys Ala Phe Ala Ala Asn Asn Ile Arg Asn 
            420                 425                 430         


Ile Ile Asp Lys Glu Gln Val Asn Asp Ile Leu Gly Lys Ser Asp Phe 
        435                 440                 445             


Glu Arg Ser Leu Ala Lys Gly Asn Phe Asp Glu Asn Arg Tyr Lys Leu 
    450                 455                 460                 


Phe Tyr Gly Val Asp Leu Lys Ser Asp Thr Ser His Ser Ala Phe Asp 
465                 470                 475                 480 


Ile Gln Ala Leu Trp Ala Met Arg Gly Ala Val Gln Gln Ile Arg Asn 
                485                 490                 495     


Glu Val Ile His Tyr His Thr Asp Thr Leu Asn Lys Ile Phe Lys Leu 
            500                 505                 510         


Asp Lys Phe Glu Tyr Lys Asp Asp Ala Asn Ala Glu Glu Cys Lys Tyr 
        515                 520                 525             


Thr Asn Thr Val Phe Gln Thr Leu Leu Glu Ser Ser Ile His Gln Leu 
    530                 535                 540                 


Asp Glu Tyr Phe Ile Glu Gln Leu Arg Ser Asn Asn Val Leu Ser Tyr 
545                 550                 555                 560 


Tyr Ala Leu Asp Ser Leu Asn His Leu Leu Gly Tyr Cys Thr Ile Ser 
                565                 570                 575     


Leu Arg Lys Ser Ser Ile Pro Phe Ala Pro Gly Phe Lys Asn Val Tyr 
            580                 585                 590         


Ala Leu Gly Ala Asn Leu Gln Tyr Gly Asn Thr Ser Met Asn Leu Lys 
        595                 600                 605             


Asn Tyr Leu Leu Lys Asp Glu Lys Gly Gln Ser Ile Asp Pro Thr Lys 
    610                 615                 620                 


Thr Lys Ser Ser His Ala Tyr Pro Ala Phe Arg Phe Ile Leu Lys Leu 
625                 630                 635                 640 


Val Tyr Asn His Ile Phe Leu Ser Arg Phe Leu Asp Asn Thr Gln Gln 
                645                 650                 655     


Asp Ala Phe Lys Glu Ala Val Thr Phe Val Leu Gln Asn Asn Arg Glu 
            660                 665                 670         


Glu Ala Ala Lys Ala Thr Lys Pro Thr Lys Gly Lys Pro Asn Phe His 
        675                 680                 685             


Ser His Gln Asp Lys Gln Glu Pro Glu Lys Tyr Ala Phe Lys Glu Ile 
    690                 695                 700                 


Arg Glu Met Gln Val Gly Glu Thr Ile Ser Ser Tyr Met Ser Tyr Ile 
705                 710                 715                 720 


Tyr Ser Tyr Ser Val Gln Glu Lys Glu Arg Lys Gly Asp Glu Asn Asp 
                725                 730                 735     


Asn Thr Arg His Asn Thr Asp Lys Phe Ile Glu Lys Val Phe Thr Lys 
            740                 745                 750         


Gly Phe Asp Ser Phe Leu Ser Thr Leu Pro Thr Ala Phe Leu Tyr Ser 
        755                 760                 765             


Pro Glu Asp Glu Gln Glu Val Glu Asn Glu Asp Tyr Gln Ala Leu Ala 
    770                 775                 780                 


Ile Gly Gln Gln Val Gln His Cys Ile Lys Ser Asp Asn Gly Thr His 
785                 790                 795                 800 


Ile Leu Phe Phe Thr Phe Cys Lys Leu Leu Asp Gly Asn His Leu Ser 
                805                 810                 815     


Asp Leu Arg Asn Glu Trp Leu Lys Tyr Tyr Ala Ser Asp Arg Thr Asp 
            820                 825                 830         


Ser Phe His Tyr Asp Phe Ala Leu Asp Ile Ile Glu Leu Cys Leu Leu 
        835                 840                 845             


Gly Lys Asp Lys Glu Ile Val Pro Thr Lys Glu Asp Ile Ile Cys Tyr 
    850                 855                 860                 


Ile Asn Thr Phe Val Glu Gly Asn Glu Lys Ser Asn Arg Ala Trp Thr 
865                 870                 875                 880 


Glu Phe Tyr Phe Gln Ser Asp Gln Asn Pro Val Glu Tyr Ala Ser Ile 
                885                 890                 895     


Asn Leu Leu Arg Lys His Gly Thr Leu Glu Leu Leu Lys Leu Ile Val 
            900                 905                 910         


Gly Asp Thr Tyr Lys Val Thr Gln Arg Asp Tyr Asp Glu Trp Lys Thr 
        915                 920                 925             


Leu Lys Glu Ser Ile Glu Asn Asp Val Asn Glu Arg Glu Ile Ile His 
    930                 935                 940                 


Lys Glu Trp Val Glu Leu Glu Asn Lys Arg Thr Glu Trp Tyr Lys Lys 
945                 950                 955                 960 


Asn Gly Arg Pro Ser Asn Lys Ala Glu Lys Asp Lys Ile Asn Arg Met 
                965                 970                 975     


Phe Gln Leu Pro Asp Ser Arg Leu Asn Lys Tyr Lys Glu Leu Cys Ile 
            980                 985                 990         


Arg Ile Glu Arg Tyr Asn Trp Leu  Asp Asn Lys Leu His  Leu Val His 
        995                 1000                 1005             


Leu Lys  Lys Leu His Asn Leu  Ile Val Gln Leu Leu  Ser Arg Met 
    1010                 1015                 1020             


Ala Arg  Phe Val Ala Leu Trp  Asp Arg Asp Phe Val  His Leu Asp 
    1025                 1030                 1035             


Ala Ser  Arg Thr Glu Asp Glu  Tyr Arg Leu Thr Ser  Phe Val Asn 
    1040                 1045                 1050             


Leu Arg  Asn Leu Lys Tyr Glu  Ala Asp Asn Lys Lys  Phe Met Asp 
    1055                 1060                 1065             


Asn Tyr  Gln Asp Ser Ile Tyr  Arg Lys Asp Gly Ser  Lys Ile Glu 
    1070                 1075                 1080             


Glu His  Asp Ile Pro Leu Ile  Lys Thr Cys Val Asn  Asn Ile Lys 
    1085                 1090                 1095             


Gln Pro  Leu Tyr Arg Glu Thr  Phe Phe Met Lys Asn  Asp Asn Ala 
    1100                 1105                 1110             


Phe Ser  Asp Arg Asn Phe Ile  Ala His Phe Asn Tyr  Ile Thr Lys 
    1115                 1120                 1125             


Ser Ala  Glu His Ser Met Val  Asp Leu Val Asn Arg  Leu Arg Met 
    1130                 1135                 1140             


Leu Met  Ala Tyr Asp Arg Lys  Leu Arg Asn Ala Val  Ser Lys Ser 
    1145                 1150                 1155             


Ile Ile  His Val Phe Glu Gln  Asn Gly Met Glu Leu  Lys Phe Lys 
    1160                 1165                 1170             


Cys Ile  Thr Arg Gly Glu Thr  Glu His Lys Leu Glu  Leu Glu Ser 
    1175                 1180                 1185             


Ile Lys  Ser Lys Lys Met Ser  Leu Leu Lys Gly Lys  Leu Glu Ile 
    1190                 1195                 1200             


Asp Gln  Val Ser Glu Glu Tyr  Cys Arg Leu Cys Lys  Arg Leu Leu 
    1205                 1210                 1215             


Glu Met  Lys Lys 
    1220         


<210>  8
<211>  1149
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  8

Met Gly Ala Gly Lys Tyr Arg Ile Thr Lys Ile Pro Arg Asn Trp Lys 
1               5                   10                  15      


Glu Asn Glu Lys Lys Val Ile Leu Lys Arg Val Val Asn Asn Gly Glu 
            20                  25                  30          


Val Lys Tyr Ile Asn Glu Asn Asp Asn Val Asp Val Asp Ile Thr Glu 
        35                  40                  45              


Thr Tyr Tyr Gly Ile Leu Ser Asn Asn Lys Ala Lys Phe Leu Gly Ser 
    50                  55                  60                  


Asn Glu Gln Phe Ile Phe Lys Val Asn Lys Met Lys Arg Asn Ile Glu 
65                  70                  75                  80  


Asn Gly Cys Val Ile Ile Lys Asn Tyr Thr Glu Glu Glu Tyr Glu Lys 
                85                  90                  95      


Phe Asp Lys Lys Ile Phe Ser Lys Arg Arg Ile Lys Val Thr Asn Lys 
            100                 105                 110         


Asn Ile Glu Lys Ile Cys Arg Asn Phe Tyr Glu Asp Glu Glu Glu Ile 
        115                 120                 125             


Met Lys Lys Arg Phe Glu Glu Ala Lys Asn Phe Asn Asn Ile Ile Phe 
    130                 135                 140                 


Lys Ile Cys Ser Glu Ile Phe Glu Leu Glu Tyr Ile Asn Tyr Thr Asp 
145                 150                 155                 160 


Glu Lys Leu Tyr Lys Ile Phe Gln Asn Lys Ile Lys Val Lys Asp Val 
                165                 170                 175     


Lys Asn Leu Lys Glu Ala Phe Lys Gln Gln Glu Lys Gly Leu Glu Thr 
            180                 185                 190         


Asp Lys Leu Leu Ala Ile Ser Phe Asn Lys Lys Arg Asn Asn Ala Leu 
        195                 200                 205             


Leu Glu Phe Ile Gln Gln Ile Val Lys Gln Lys Phe Glu Asn Glu Lys 
    210                 215                 220                 


Glu Leu Glu Asn Trp Phe Ser His Ser Gly Glu Lys Tyr Cys Lys Glu 
225                 230                 235                 240 


Ile Phe Lys Ile Tyr Ser Asn Met Ser Gln Lys Glu Lys Tyr Ser Lys 
                245                 250                 255     


Leu Leu Gly His Arg Asn Lys Ser Phe Ala Ser Ile Ser Glu Lys Lys 
            260                 265                 270         


Glu Thr Leu Gln Arg Arg Leu Lys Leu Gly Asn Tyr Ser Asn Tyr Asn 
        275                 280                 285             


Leu Arg Lys Tyr Tyr Gln Lys Asp Tyr Lys Glu Glu Ala Ile Lys Glu 
    290                 295                 300                 


Leu Lys Asp Lys Ser Lys Glu Lys Leu Glu Lys Glu Ile Glu Glu Ile 
305                 310                 315                 320 


Ile Lys Glu Asn Tyr Lys Ile Asp Lys Leu Cys Glu Glu Ile Ser Asn 
                325                 330                 335     


Leu Glu Phe Ser Phe Ala Glu Ser Lys Lys Glu Asn Lys Asp Lys Met 
            340                 345                 350         


Ser Glu Ile Ile Val Lys Ile Lys Glu His Tyr Lys Asn Asn Val Asn 
        355                 360                 365             


Val Glu Glu Glu Leu Glu Asn Lys Glu Lys Tyr Ile Leu Ser Met Ile 
    370                 375                 380                 


His Asn Tyr Ile Lys Gly Arg Tyr Arg Lys Cys Leu Glu Leu Gln Gln 
385                 390                 395                 400 


Lys Glu Asn Val Asp Phe Glu Asn Leu Glu Lys Arg Ile Lys Glu Ile 
                405                 410                 415     


Phe Asp Ser Asn Glu Val Thr Lys Lys Leu Lys Lys Leu Ile Leu Asn 
            420                 425                 430         


Lys Val Asn Asn Tyr Lys Ile Phe Glu Thr Lys Phe Gln Asn Pro Asn 
        435                 440                 445             


Ile Glu Ser Ser Asp Asp Leu Glu Ile Leu Lys Ala Glu Glu Thr Phe 
    450                 455                 460                 


Leu Asn Lys Leu Ser Thr Ala Val Ser Lys Val Gly Tyr Thr Leu Asn 
465                 470                 475                 480 


Thr Leu Leu Glu Val Ser Pro Glu Lys Asp Ile Leu Glu Lys Tyr Glu 
                485                 490                 495     


Glu Val Glu Lys Leu Cys Thr Ser Asn Ser Ile Lys Asn Leu Cys Thr 
            500                 505                 510         


Val Tyr Ser Glu Ile Asn Asn Asn Glu Lys Leu Leu Lys Gly Met Ile 
        515                 520                 525             


Tyr Phe Ile Gln Gly Leu Arg Gln Gln Val Leu His Pro Lys Ile Leu 
    530                 535                 540                 


Trp Glu Lys Asn Val His Lys Ala Glu Lys Val Lys Glu Lys Glu Lys 
545                 550                 555                 560 


Ile Val Ile Arg Phe Gln Asn Glu Gly Lys Ala Tyr Asn Lys Lys Arg 
                565                 570                 575     


Ile Glu Glu Tyr Phe Glu Asn Ile Leu Glu Lys Ile Pro Asp Tyr Phe 
            580                 585                 590         


Ile Glu Lys Tyr Glu Ser Asn Asn Val Phe Asn Ile Tyr Arg Asn Phe 
        595                 600                 605             


Ile Asp Glu Ile Phe Glu Ile Ile Asp Lys Phe Asp Phe Lys Glu Ser 
    610                 615                 620                 


Asn Ser Ile Ser Tyr Leu Phe Pro Lys Phe His Lys Ile Tyr Lys Arg 
625                 630                 635                 640 


Ile Cys Lys Ser Glu Asn Ile Asn Asp Arg Gln Asn Gly Ala Arg Lys 
                645                 650                 655     


Tyr Leu Leu Gln Thr Ile Tyr Tyr Tyr Tyr Phe Gln Tyr Glu Ile Glu 
            660                 665                 670         


Asn Asn Lys Asn Asp Ile Phe Lys Tyr Leu Asn Leu Tyr Lys Ser Lys 
        675                 680                 685             


Ile Lys Ala Lys Lys Ile Ser Tyr Ser His Ile Ile Asp Asn Lys Asp 
    690                 695                 700                 


Val Asn Asn Lys Asn Ile Glu Ile Leu Tyr Arg Asn Ile Gln Arg Glu 
705                 710                 715                 720 


Gly Met Leu Asn Asn Arg Leu Leu Gln Met Asn Asn Glu Trp Ile Glu 
                725                 730                 735     


Phe Ile Met Ile Gln Phe Ile Glu Phe Ile Ser Thr Lys Lys Leu Asn 
            740                 745                 750         


Trp Ile Leu Asp Asp Leu Ser Glu Tyr Arg Lys Lys Glu Lys Leu Asp 
        755                 760                 765             


Glu Lys Asn Lys Asn Lys Leu Leu Glu Asn Leu Lys Gln Lys Met Asn 
    770                 775                 780                 


Lys Asn Ile Thr Tyr Ser Asn Asp Ser Tyr Val Phe Ile Ser Leu Ala 
785                 790                 795                 800 


Gln Phe Leu Asp Leu Lys Glu Ile Ser Asn Leu Ile His Asp Ile Lys 
                805                 810                 815     


Lys Phe Val Gln Phe Arg Glu Lys Asn Ile Ser Lys Tyr Lys Pro Glu 
            820                 825                 830         


Lys Asn Lys Val Tyr Ile Glu Glu Leu Arg Lys Ile Ser Tyr Ile Leu 
        835                 840                 845             


Lys Val Met Leu Glu His Lys Glu Arg Val Ile Gln Lys His Tyr Leu 
    850                 855                 860                 


Glu Ser Tyr Asp Glu Gly Ile Ser Ile Met Tyr Gly Lys Asp Ile Glu 
865                 870                 875                 880 


Lys Lys Gly Ile Lys Asp Ile Lys Ile Lys Ile Lys Asn Glu Asn Gln 
                885                 890                 895     


Glu Val Ile Asn Gln Pro Leu Tyr Lys Ser Gly Asn Asp Glu Asn Ser 
            900                 905                 910         


Ser Trp Ile Val Leu Tyr Gly Ile Glu Gln Ala Lys Arg Asn Gly Thr 
        915                 920                 925             


Phe Lys Phe Phe Lys Glu Phe Phe Asn Thr Asn Glu Asp Ile Lys Leu 
    930                 935                 940                 


Cys Lys Glu Asp Ile Gln Lys Tyr Glu His Leu Tyr Asn Glu Lys Glu 
945                 950                 955                 960 


Glu Asn Gln Arg Lys Val Asp Glu Tyr Ile Ser Ser Glu Glu Asn Asn 
                965                 970                 975     


Asn Ile Glu Glu Ile Lys Glu Ile Asn Asn Asn Lys Lys Gln Leu Phe 
            980                 985                 990         


Tyr Tyr Tyr Lys Asn Met Ile Asn  Gly Asp Gly Leu Lys  Lys Gly Tyr 
        995                 1000                 1005             


Asp Phe  Ile Asn Asp Ile Tyr  Ser His Cys Leu Ser  Trp Ala Tyr 
    1010                 1015                 1020             


Arg Ile  Glu Arg Asp Cys Ser  Ile Tyr Lys Val Glu  Ala Tyr Asn 
    1025                 1030                 1035             


Gly Lys  Ile Lys Asn Phe Arg  Asn Glu Ile Ala His  Phe Asn Tyr 
    1040                 1045                 1050             


Phe Gln  Lys Thr Asp Lys Ser  Leu Leu Asp Leu Leu  Asn Asp Phe 
    1055                 1060                 1065             


Tyr Asn  Ile Phe Asp Tyr Asn  Leu Lys Tyr Gln Arg  Asp Val Gln 
    1070                 1075                 1080             


Lys Val  Ile Asn Asn Ile Phe  Glu Lys Tyr Gln Val  Val Arg Glu 
    1085                 1090                 1095             


Asp Gly  Gly Pro Val Ile Phe  Tyr Cys Lys Val Asp  Lys Lys Leu 
    1100                 1105                 1110             


Lys Leu  Ser Glu Asn Leu Val  Pro Lys Lys His Ser  Lys Tyr Pro 
    1115                 1120                 1125             


Glu Ile  Glu Leu Val His Lys  Lys Tyr Val Ile Phe  Phe Lys Lys 
    1130                 1135                 1140             


Leu Phe  Glu His Lys Lys 
    1145                 


<210>  9
<211>  1100
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  9

Met Asp Arg Asn Ile Lys Asn Asp Tyr Val Ile Ile Lys Asp Tyr Asn 
1               5                   10                  15      


Asp Glu Glu Phe Glu Lys Phe Asp Lys Lys Ile Phe Phe Ser Arg Lys 
            20                  25                  30          


Ile Lys Val Asn Asn Glu Asp Arg Glu Lys Ile Cys Arg Asn Phe Tyr 
        35                  40                  45              


Glu Asp Glu Arg Glu Ile Met Lys Lys Arg Leu Glu Glu Ala Lys Asn 
    50                  55                  60                  


Phe Asn Asn Ile Ile Phe Asn Ile Cys Asn Lys Ile Phe Lys Leu Glu 
65                  70                  75                  80  


Tyr Leu Asp Cys Thr Asp Glu Lys Val Tyr Lys Ile Phe Gln Asn Glu 
                85                  90                  95      


Ile Lys Val Lys Asp Val Lys Asn Leu Lys Glu Ala Phe Lys Gln Gln 
            100                 105                 110         


Glu Lys Gly Leu Glu Thr Asp Lys Leu Leu Ala Ile Ser Phe Asn Lys 
        115                 120                 125             


Lys Arg Asn Asn Ile Leu Leu Glu Phe Ile Gln Gln Ile Val Lys Gln 
    130                 135                 140                 


Lys Phe Glu Lys Glu Lys Glu Leu Glu Asn Trp Phe Ser His Glu Gly 
145                 150                 155                 160 


Glu Lys Tyr Cys Lys Glu Ile Phe Lys Ile Tyr Ser Asn Met Ser Gln 
                165                 170                 175     


Lys Glu Lys Tyr Ser Lys Leu Leu Gly His Asn Asp Lys Ser Thr Ala 
            180                 185                 190         


Ser Tyr Ser Glu Lys Arg Glu Thr Leu Gln Arg Arg Leu Lys Leu Gly 
        195                 200                 205             


Asp Tyr Ser Lys Tyr Asp Leu Lys Lys Tyr Tyr Gln Lys Asp Tyr Lys 
    210                 215                 220                 


Glu Glu Ala Ile Ile Glu Leu Lys Asp Lys Asn Lys Glu Glu Leu Glu 
225                 230                 235                 240 


Arg Glu Ile Glu Glu Leu Ile Lys Lys Asn Tyr Lys Ile Asp Lys Leu 
                245                 250                 255     


Cys Asp Glu Ile Ser Asn Leu Glu Phe Ser Phe Val Glu Ser Arg Lys 
            260                 265                 270         


Glu Asn Lys Tyr Lys Met Ser Glu Ile Ile Val Lys Ile Lys Glu His 
        275                 280                 285             


Tyr Lys Lys Asn Val Asn Val Glu Glu Glu Leu Lys Asn Lys Glu Lys 
    290                 295                 300                 


Tyr Ile Leu Ser Ile Ile His Asn Tyr Val Lys Gly Arg Tyr Arg Lys 
305                 310                 315                 320 


Cys Leu Glu Leu Gln Gln Lys Glu Asn Val Asp Phe Glu Asn Leu Gly 
                325                 330                 335     


Lys Arg Ile Lys Glu Ile Phe Asp Ser Asn Gln Val Thr Lys Lys Leu 
            340                 345                 350         


Lys Lys Ser Ile Leu Asn Lys Val Asn Asn Tyr Lys Ile Phe Glu Thr 
        355                 360                 365             


Lys Phe Gln Asn Pro Asn Ile Glu Ser Ser Asn Asp Leu Glu Ile Leu 
    370                 375                 380                 


Lys Ala Glu Glu Thr Phe Leu Asn Lys Leu Ser Thr Ala Val Ser Lys 
385                 390                 395                 400 


Val Gly Tyr Thr Leu Asn Thr Leu Leu Glu Val Ser Pro Glu Lys Asp 
                405                 410                 415     


Ile Leu Glu Asn Tyr Asn Met Val Val Glu Leu Cys Asn Asn Asn Ser 
            420                 425                 430         


Thr Thr Glu Ile Tyr Lys Val Tyr Pro Glu Leu Glu Lys Asn Glu Lys 
        435                 440                 445             


Leu Leu Gln Gly Met Ile His Phe Ile Gln Gly Leu Arg Gln Gln Ser 
    450                 455                 460                 


Leu His Pro Lys Ile Ser Trp Asn Phe Glu Thr Lys Asn Leu Lys Pro 
465                 470                 475                 480 


Glu Lys Leu Glu Arg Leu Lys Glu Lys Lys Asn Ile Lys Met Arg Asp 
                485                 490                 495     


Cys Val Val His Glu Asp Asn Leu Asp Lys Lys Glu Lys Ser Glu Val 
            500                 505                 510         


Glu Ile Lys Arg Tyr Phe Glu Lys Ile Glu Glu Lys Leu Pro Asp Tyr 
        515                 520                 525             


Phe Ile Glu Lys Tyr Glu Ser Asn Asn Val Phe Asn Ile Tyr Arg Asn 
    530                 535                 540                 


Phe Val Asp Lys Ile Met Glu Ala Ile Lys Asn Phe Asn Phe Lys Glu 
545                 550                 555                 560 


Asn Asn Thr Ile Asp Tyr Leu Phe Pro Lys Phe His Lys Ile Tyr Lys 
                565                 570                 575     


Arg Met Tyr Lys Ser Glu Asn Ile Asp Asp Arg Gln Asn Gly Ala Arg 
            580                 585                 590         


Lys Tyr Leu Leu Gln Thr Ile Tyr Tyr Tyr Tyr Phe Gln Tyr Lys Ile 
        595                 600                 605             


Glu Asn Asp Lys Asn Asp Ile Phe Lys Tyr Leu Asn Leu Tyr Lys Asn 
    610                 615                 620                 


Lys Ile Lys Ala Lys Lys Ile Ser Tyr Ser Tyr Ile Ile Asp Asn Lys 
625                 630                 635                 640 


Asn Val Asn Asn Lys Asn Ile Glu Ile Leu Tyr Lys Asn Ile Gln Arg 
                645                 650                 655     


Glu Gly Ile Leu Asn Asn Arg Leu Ser Gln Met Asn Asn Glu Trp Ile 
            660                 665                 670         


Glu Phe Ile Val Val Gln Phe Ser Glu Phe Leu Thr Asn Lys Lys Leu 
        675                 680                 685             


Asn Trp Ile Leu Asp Asp Leu Ser Glu Tyr Lys Lys Lys Glu Lys Leu 
    690                 695                 700                 


Asp Asn Ser Asp Lys Asp Lys Leu Arg Glu Met Leu Lys Leu Lys Met 
705                 710                 715                 720 


Asn Lys Lys Leu Ile Tyr Ser Asn Asp Ser Tyr Val Phe Ile Ser Leu 
                725                 730                 735     


Ala Gln Phe Leu Asp Leu Lys Glu Ile Ser Asn Leu Ile His Asp Ile 
            740                 745                 750         


Lys Lys Phe Ile Gln Phe Arg Glu Lys Asn Val Ser Lys Tyr Lys Pro 
        755                 760                 765             


Glu Lys Asn Lys Leu Tyr Ile Glu Glu Leu Lys Lys Ile Leu Tyr Ile 
    770                 775                 780                 


Leu Lys Val Met Leu Glu His Lys Glu Arg Val Ile Gln Lys His Tyr 
785                 790                 795                 800 


Leu Glu Ser Tyr Asp Glu Asn Ile Ser Ile Met Tyr Gly Lys Asp Ile 
                805                 810                 815     


Glu Lys Lys Asp Ile Lys Asp Ile Glu Ile Lys Ile Lys Asn Lys Asn 
            820                 825                 830         


Gln Glu Val Ile Asn Gln Pro Leu Tyr Lys Ser Gly Asn Asp Glu Lys 
        835                 840                 845             


Ser Ser Trp Ile Val Leu Tyr Gly Ile Glu Gln Ala Lys Arg Asn Gly 
    850                 855                 860                 


Thr Phe Lys Phe Phe Glu Gly Phe Phe Asn Leu Asn Asp Asp Ile Lys 
865                 870                 875                 880 


Leu Cys Lys Lys Asp Ile Lys Arg Tyr Glu Lys Leu Tyr Asn Glu Lys 
                885                 890                 895     


Glu Asp Ser Gln Lys Val Val Asp Asp Tyr Ile Ser Leu Asn Glu His 
            900                 905                 910         


Ser Ser Ile Pro Thr Lys Glu Leu Ile Lys Lys Asn Cys Lys Lys Gln 
        915                 920                 925             


Leu Phe Tyr Tyr Tyr Lys Asn Met Ile Tyr Gly Asp Gly Leu Lys Lys 
    930                 935                 940                 


Gly Tyr Asp Phe Ile Asn Asp Ile Tyr Ser His Tyr Leu Ser Trp Ala 
945                 950                 955                 960 


Tyr Arg Ile Glu Arg Asp Cys Lys Ile Tyr Lys Ile Lys Lys Tyr Glu 
                965                 970                 975     


Asn Lys Lys Asn Ser Asn Glu Tyr Lys Phe Lys Glu Tyr Lys Ser Ile 
            980                 985                 990         


Gln Asn Phe Arg Asn Lys Ile Ala  His Phe Asn Tyr Phe  Gln Lys Thr 
        995                 1000                 1005             


Asp Lys  Ser Leu Leu Asp Leu  Leu Asn Asp Phe Tyr  Ser Ile Phe 
    1010                 1015                 1020             


Asp Tyr  Asn Leu Lys Tyr Gln  Arg Asp Val Gln Lys  Val Ile Asn 
    1025                 1030                 1035             


Asn Ile  Phe Glu Lys Tyr Gln  Val Val Arg Glu Asp  Glu Gly Pro 
    1040                 1045                 1050             


Val Ile  Phe Tyr Cys Lys Val  Asp Lys Lys Leu Lys  Leu Ser Glu 
    1055                 1060                 1065             


Asn Leu  Val Pro Lys Lys His  Ser Lys Tyr Gln Glu  Ile Lys Leu 
    1070                 1075                 1080             


Ile His  Glu Lys Tyr Val Val  Phe Phe Lys Lys Leu  Phe Glu Tyr 
    1085                 1090                 1095             


Lys Lys  
    1100 


<210>  10
<211>  1214
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  10

Met Lys Val Thr Lys Ile Asp Gly Leu Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Lys Gly Lys Leu Val Arg Phe Asn Ser Glu Asn Lys Glu Glu Lys Ser 
            20                  25                  30          


Asn Asn Asp Thr Asn Lys Glu Thr Lys Thr Glu Met Glu Lys Arg Ile 
        35                  40                  45              


Glu Lys Leu Lys Glu Leu Lys Leu Asp Asn Tyr Ile Lys Asn Pro Glu 
    50                  55                  60                  


Asn Val Lys Asn Glu Asp Lys Asp Ala Glu Lys Glu Thr Lys Ile Arg 
65                  70                  75                  80  


Arg Thr Asn Leu Lys Lys Tyr Phe Ser Glu Ile Ile Leu Arg Glu Glu 
                85                  90                  95      


Gly Lys Lys Tyr Ile Leu Val Lys Ser Lys Lys Phe Lys Asn Ile Asn 
            100                 105                 110         


Gln Glu Ile Asp Tyr Tyr Asp Ile Lys Lys Lys Glu Asn Gln Gln Glu 
        115                 120                 125             


Ile Phe Asn Val Leu Lys Glu Ile Leu Glu Leu Lys Ile Lys Asn Asn 
    130                 135                 140                 


Glu Lys Glu Glu Tyr Ile Asn Phe Asp Ser Glu Lys Leu Lys Glu Ala 
145                 150                 155                 160 


Phe Glu Lys Asp Phe Val Lys Lys Val Leu Lys Ile Glu Ala Val Lys 
                165                 170                 175     


Lys Ser Leu Glu Ile Asn Arg Ala Asn Tyr Lys Lys Thr Leu Val Glu 
            180                 185                 190         


Ile Gly Asn Asp Lys Tyr Glu Asn Val Lys Gly Glu Asn Lys Arg Ser 
        195                 200                 205             


Cys Ile Tyr Glu Tyr Tyr Lys Lys Ser Glu Thr His Glu Lys Phe Arg 
    210                 215                 220                 


Lys Asn Ile Ile Glu Ala Phe Glu Lys Leu Tyr Thr Glu Glu Asn Ile 
225                 230                 235                 240 


Lys Glu Leu Tyr Ser Lys Ile Glu Glu Val Phe Lys Lys Thr His Leu 
                245                 250                 255     


Lys Ser Ile Val Arg Glu Phe Tyr Gln Asn Glu Ile Ile Arg Glu Ser 
            260                 265                 270         


Glu Phe Ser Glu Lys Gly Glu Asp Gly Ile Ser Ile Leu Tyr Asn Gln 
        275                 280                 285             


Ile Thr Lys Ser Asn Glu Lys Lys Glu Lys Phe Val Glu Phe Leu Glu 
    290                 295                 300                 


Asn Ile Glu Asn Leu Gln Leu Lys Glu Leu Thr Lys Ser Gln Ile Phe 
305                 310                 315                 320 


Tyr Lys Tyr Phe Leu Lys Asn Glu Glu Leu Asn Asp Glu Asn Ile Lys 
                325                 330                 335     


Phe Ala Phe Cys Tyr Phe Val Glu Ile Glu Val Asn Asn Leu Leu Lys 
            340                 345                 350         


Glu Asn Val Tyr Glu Ile Lys Arg Phe Asn Glu Ser Asn Lys Lys Arg 
        355                 360                 365             


Ile Glu Asn Ile Phe Glu Tyr Asp Lys Leu Lys Lys Leu Ile Val Tyr 
    370                 375                 380                 


Lys Leu Glu Asn Lys Leu Asn Asn Tyr Val Arg Asn Cys Gly Lys Tyr 
385                 390                 395                 400 


Asn Tyr His Met Glu Asn Ala Asp Ile Ala Thr Ser Asp Ile Asn Met 
                405                 410                 415     


Arg Asn Arg Gln Thr Glu Ala Phe Leu Arg Ser Met Ile Gly Val Ser 
            420                 425                 430         


Ser Phe Gly Tyr Phe Ser Leu Arg Asn Ile Leu Gly Val Asn Asp Asp 
        435                 440                 445             


Asp Phe Tyr Glu Ile Glu Glu Asp Leu Thr Glu Asp Glu Arg Lys Glu 
    450                 455                 460                 


Gln Ser Asn Thr Leu Lys Lys Ala Lys Glu Asp Ile Thr Ser Thr Asn 
465                 470                 475                 480 


Lys Ser Ile Phe Glu Lys Val Val Gly Lys Ser Phe Glu Lys Lys Gly 
                485                 490                 495     


Ile Tyr Ser Ile Lys Glu Asn Leu Lys Met Phe Tyr Gly Asp Ser Phe 
            500                 505                 510         


Asp Asp Thr Asn Glu Asp Glu Leu Lys Gln Phe Phe Val Asn Met Leu 
        515                 520                 525             


Asn Ala Ile Ile Ser Ile Arg His Arg Val Val His Tyr Asn Met Asn 
    530                 535                 540                 


Thr Asn Ser Glu Asn Ile Phe Asn Phe Ser Asp Ile Glu Val Ser Arg 
545                 550                 555                 560 


Leu Leu Lys Asn Ile Phe Glu Lys Glu Thr Asp Lys Arg Glu Leu Lys 
                565                 570                 575     


Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Gly Val Phe Asp Tyr Trp 
            580                 585                 590         


Glu Ser Trp Lys Ile Lys Lys Tyr Leu Glu Asn Ile Glu Phe Lys Phe 
        595                 600                 605             


Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys Leu Tyr Asn 
    610                 615                 620                 


Arg Ile Asp Asn Leu Lys Gly Asn Asn Ala Leu Asn Leu Gly Tyr Ile 
625                 630                 635                 640 


Asn Ile Pro Lys Arg Lys Glu Ala Arg Asp Ser Gln Ile Tyr Leu Leu 
                645                 650                 655     


Lys Asn Ile Tyr Tyr Gly Glu Phe Val Glu Lys Phe Val Asn Asn Asn 
            660                 665                 670         


Asp Asn Phe Glu Lys Ile Phe Arg Glu Ile Ile Glu Ile Asn Lys Lys 
        675                 680                 685             


Ala Gly Ile Asn Thr Lys Thr Lys Phe Tyr Lys Leu Glu Lys Phe Glu 
    690                 695                 700                 


Thr Leu Lys Ala Asn Ala Pro Ile Glu Tyr Leu Glu Lys Leu Gln Ser 
705                 710                 715                 720 


Leu His Gln Ile Asn Tyr Asn Arg Glu Lys Val Glu Glu Asp Lys Asp 
                725                 730                 735     


Ile Tyr Val Asp Phe Val Gln Lys Ile Phe Leu Lys Gly Phe Ile Asn 
            740                 745                 750         


Tyr Leu Gln Glu Ser Asp Ser Leu Lys Ser Leu Asn Leu Leu Asn Leu 
        755                 760                 765             


Lys Lys Asp Glu Ala Ile Ala Asn Lys Lys Ser Phe Tyr Asp Glu Lys 
    770                 775                 780                 


Leu Lys Leu Trp Lys Asn Asn Gly Ser Asn Leu Ser Lys Met Leu Glu 
785                 790                 795                 800 


Glu Ile Tyr Glu Tyr Ile Lys Lys Ile Lys Ile Asn Lys Ile Asn Tyr 
                805                 810                 815     


Ser Asp Arg Met Ser Ile Phe Tyr Leu Leu Leu Lys Leu Ile Asp Tyr 
            820                 825                 830         


Arg Glu Leu Thr Asn Leu Arg Gly Asn Leu Glu Lys Tyr Glu Ser Met 
        835                 840                 845             


Asn Lys Asn Lys Ile Tyr Ser Glu Glu Leu Asn Ile Val Asn Leu Val 
    850                 855                 860                 


Ser Leu Asp Asn Asn Lys Val Arg Ala Asn Phe Asn Leu Lys Pro Glu 
865                 870                 875                 880 


Asp Ile Gly Lys Phe Leu Lys Thr Glu Thr Ser Ile Arg Asn Ile Asn 
                885                 890                 895     


Gln Leu Asn Lys Phe Ser Glu Ile Phe Ala Asp Gly Glu Asn Val Ile 
            900                 905                 910         


Lys His Arg Ser Phe Tyr Asn Ile Lys Lys Tyr Gly Ile Leu Asp Leu 
        915                 920                 925             


Leu Glu Lys Ile Val Asp Lys Ala Asp Leu Lys Ile Thr Lys Glu Glu 
    930                 935                 940                 


Ile Lys Glu Tyr Lys Asn Leu Gln Lys Glu Leu Glu Lys Asn Asp Phe 
945                 950                 955                 960 


Tyr Lys Ile Gln Glu Asn Ile His Arg Lys Tyr Asn Gln Lys Ser Asn 
                965                 970                 975     


Trp Ile Ser Arg Ile Glu Asn Lys Lys Asp Phe Asn Asp Tyr Lys Lys 
            980                 985                 990         


Ala Ile Glu Asn Ile Gln Asn Tyr  Thr Gln Leu Lys Asn  Lys Ile Glu 
        995                 1000                 1005             


Phe Asn  Asp Leu Asn Leu Leu  Gln Ser Leu Leu Phe  Arg Ile Leu 
    1010                 1015                 1020             


His Arg  Leu Ala Gly Tyr Thr  Ser Leu Trp Glu Arg  Asp Leu Gln 
    1025                 1030                 1035             


Phe Lys  Leu Lys Gly Glu Phe  Pro Glu Asp Lys Tyr  Ile Asp Glu 
    1040                 1045                 1050             


Ile Phe  Asn Ser Asp Gly Asn  Asn Asn Gln Lys Tyr  Lys Asn Gly 
    1055                 1060                 1065             


Gly Ile  Ala Asp Lys Tyr Ala  Asp Phe Leu Ile Glu  Lys Glu Glu 
    1070                 1075                 1080             


Glu Lys  Ser Gly Glu Ile Leu  Lys Lys Asn Gln Arg  Ile Lys Arg 
    1085                 1090                 1095             


Lys Lys  Lys Ile Lys Glu Asp  Leu Glu Ile Arg Asn  Tyr Ile Ala 
    1100                 1105                 1110             


His Phe  Asn Tyr Phe Pro Asp  Ala Thr Lys Ser Ile  Leu Glu Leu 
    1115                 1120                 1125             


Leu Glu  Glu Leu Arg Glu Leu  Leu Lys Tyr Asp Arg  Lys Leu Lys 
    1130                 1135                 1140             


Asn Ala  Val Met Lys Ser Val  Lys Asp Ile Phe Lys  Glu Tyr Gly 
    1145                 1150                 1155             


Phe Ile  Val Glu Phe Glu Ile  Ser His Glu Ser Asn  Ser Lys Lys 
    1160                 1165                 1170             


Ile Lys  Val Cys Asp Val Lys  Ser Glu Glu Ile Lys  His Leu Lys 
    1175                 1180                 1185             


Asn Asn  Gly Leu Val Thr Thr  Arg Asn Ser Glu Asp  Leu Cys Glu 
    1190                 1195                 1200             


Leu Ile  Lys Val Met Leu Glu  Tyr Lys Lys Ser 
    1205                 1210                 


<210>  11
<211>  1143
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  11

Met Arg Val Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Val Tyr Ser Gly 
            20                  25                  30          


Gln Pro Val Ser Asn Glu Thr Cys Asn Ile Leu Pro Glu Lys Lys Arg 
        35                  40                  45              


Gln Ser Phe Asp Leu Ser Ile Glu Asn Lys Thr Leu Lys Arg Arg Asp 
    50                  55                  60                  


Asp Val Asp Lys Thr Lys Lys Gly Lys Tyr Asp Ile Val Arg Lys Ile 
65                  70                  75                  80  


Ile Lys Tyr Gly Glu Leu Pro Gln Ser Ile Asn Asp Val Asp Ile Leu 
                85                  90                  95      


Glu Phe Leu Asn His Lys Phe Gln Lys Pro Val Lys Tyr Trp Lys Asn 
            100                 105                 110         


Gly Lys Glu Glu Ser Phe Asn Leu Thr Leu Leu Ile Val Glu Ala Val 
        115                 120                 125             


Lys Thr Gln Asp Arg Gln Lys Leu Gln Pro Tyr Tyr Asp Trp Lys Thr 
    130                 135                 140                 


Trp Tyr Ile Gln Thr Lys Ser Asp Leu Leu Lys Lys Ser Ile Glu Asn 
145                 150                 155                 160 


Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg Lys Lys Ala Leu 
                165                 170                 175     


Leu Ala Trp Glu Thr Glu Phe Thr Thr Ser Gly Lys Ile Asp Leu Thr 
            180                 185                 190         


His Tyr His Lys Val Tyr Met Thr Asp Val Leu Cys Thr Ala Leu Gln 
        195                 200                 205             


Lys Val Glu Pro Ser Thr Asp Lys Lys Gly Lys Ile Asn Thr Asn Ala 
    210                 215                 220                 


Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Thr His Gln Pro Ala Ile 
225                 230                 235                 240 


Phe Gly Thr Arg Gln Ala Pro Asn Asn Val Asn Arg Ala Asp Asp Arg 
                245                 250                 255     


Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu Glu His Tyr Phe 
            260                 265                 270         


Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Ala Asp Asp Ile Glu His 
        275                 280                 285             


Tyr Leu Lys Thr Gln Thr Leu Lys Thr Thr Ile Glu Lys Gln Leu Val 
    290                 295                 300                 


Asn Ala Ile Arg Ala Asn Ile Ile Gln Gln Gly Lys Thr Asn His His 
305                 310                 315                 320 


Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile Arg Ile Lys Thr 
                325                 330                 335     


Asn Glu Ala Phe Val Leu Asn Leu Thr Gly Thr Cys Ala Phe Ala Ala 
            340                 345                 350         


Asn Asn Ile Arg Asn Met Val Asp Asn Glu Gln Thr Asn Asp Ile Leu 
        355                 360                 365             


Gly Lys Gly Asp Phe Ile Lys Ser Leu Leu Lys Asp Asn Thr Asn Gly 
    370                 375                 380                 


Gln Leu Tyr Ser Phe Phe Phe Gly Glu Ser Leu Ser Thr Asn Lys Ala 
385                 390                 395                 400 


Glu Lys Glu Thr Gln Leu Trp Gly Ile Arg Gly Ala Val Gln Gln Ile 
                405                 410                 415     


Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu Lys Thr Val Phe 
            420                 425                 430         


Asn Ile Ser Asn Phe Glu Asn Pro Thr Ile Thr Asp Pro Lys Gln Gln 
        435                 440                 445             


Thr Asn Tyr Ala Asp Thr Ile Tyr Lys Ala Leu Phe Ile Lys Glu Leu 
    450                 455                 460                 


Glu Lys Ile Pro Asn Ala Phe Ala Gln Gln Leu Lys Thr Gly Gly Ala 
465                 470                 475                 480 


Leu Ser Tyr Tyr Thr Ile Glu Asn Leu Lys Ser Leu Leu Thr Thr Phe 
                485                 490                 495     


Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala Pro Gly Phe Lys 
            500                 505                 510         


Lys Val Phe Asn Gly Gly Ile Asn Tyr Gln Asn Ala Lys Gln Asp Glu 
        515                 520                 525             


Ser Phe Tyr Glu Leu Met Leu Glu Arg Tyr Leu Arg Lys Glu Asn Phe 
    530                 535                 540                 


Ala Glu Glu Ala Tyr Asn Ala Arg Tyr Phe Leu Leu Lys Leu Ile Tyr 
545                 550                 555                 560 


Asn Asn Leu Phe Leu Pro Gly Phe Thr Arg Asp Arg Lys Ala Phe Ala 
                565                 570                 575     


Asp Ser Val Gly Phe Val Gln Met Gln Asn Lys Lys Gln Ala Glu Lys 
            580                 585                 590         


Val Asn Pro Lys Lys Arg Glu Ala Tyr Ala Phe Glu Ala Val Arg Pro 
        595                 600                 605             


Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala Tyr Val Gln Ser 
    610                 615                 620                 


Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys Ala Thr Asp Glu 
625                 630                 635                 640 


Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val Phe Val Lys Gly 
                645                 650                 655     


Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe Val Gln Val Pro 
            660                 665                 670         


Gln Pro Gln Leu Thr Ala Thr Ala Ser Asn Gln Gln Lys Ala Asp Lys 
        675                 680                 685             


Leu Asn Gln Leu Glu Ala Ser Ile Thr Ala Asp Cys Lys Leu Thr Pro 
    690                 695                 700                 


Gln Tyr Ala Lys Ala Asp Asn Ala Thr His Ile Ala Phe Tyr Val Phe 
705                 710                 715                 720 


Cys Lys Leu Leu Asp Ala Gly His Leu Ser Asn Leu Arg Asn Glu Leu 
                725                 730                 735     


Ile Lys Phe Arg Glu Ser Val Asn Glu Phe Lys Phe His His Leu Leu 
            740                 745                 750         


Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val Val Pro Thr Asp 
        755                 760                 765             


Tyr Arg Asp Leu Tyr Ser Ser Glu Ala Asp Cys Leu Ala Arg Leu Arg 
    770                 775                 780                 


Pro Phe Ile Glu Gln Gly Ala Asp Ile Thr Asn Trp Ser Asp Leu Phe 
785                 790                 795                 800 


Val Gln Ser Asp Lys His Ser Pro Val Ile His Ala Asn Ile Glu Leu 
                805                 810                 815     


Ser Val Lys Tyr Gly Thr Thr Lys Leu Leu Glu Gln Ile Ile Asn Lys 
            820                 825                 830         


Asp Pro Gln Phe Lys Thr Thr Glu Ala Asn Phe Thr Ala Trp Asn Thr 
        835                 840                 845             


Ala Gln Lys Ser Ile Glu Gln Leu Ile Lys Gln Arg Glu Asp His His 
    850                 855                 860                 


Glu Gln Trp Val Lys Ala Lys Asn Ala Asp Asp Lys Glu Lys Gln Glu 
865                 870                 875                 880 


Arg Lys Arg Glu Lys Ser Asn Phe Ala Gln Lys Phe Ile Glu Lys His 
                885                 890                 895     


Gly Asp Asp Tyr Leu Asp Ile Cys Asp Tyr Ile Asn Thr Tyr Asn Trp 
            900                 905                 910         


Leu Asp Asn Lys Met His Phe Val His Leu Asn Arg Leu His Gly Leu 
        915                 920                 925             


Thr Ile Glu Leu Leu Gly Arg Met Ala Gly Phe Val Ala Leu Phe Asp 
    930                 935                 940                 


Arg Asp Phe Gln Met Leu Asp Ala Lys Arg Ile Ser Asp Leu Tyr Gln 
945                 950                 955                 960 


Leu Lys Ser Phe Ile Ser Phe Arg Glu Ile Thr Ser Glu Leu Asp Lys 
                965                 970                 975     


Asn Asn Asp Ile Thr Glu Ile Asn Leu Ile Lys Asp Lys Glu Ile Ile 
            980                 985                 990         


Lys Arg Asp Gly Thr Pro Ile Thr  Glu Ala Asp Arg Asn  Ser Leu Lys 
        995                 1000                 1005             


Ser Cys  Ile Gln Ser Lys Arg  Glu Tyr Tyr Gln Lys  Thr Tyr Phe 
    1010                 1015                 1020             


Lys Glu  His Thr Asn Pro Phe  Thr Asp Arg Asn Tyr  Ile Ala His 
    1025                 1030                 1035             


Phe Asn  Tyr Leu Ser Thr Asn  Thr Gly Asn His Ser  Leu Ile Lys 
    1040                 1045                 1050             


Leu Ile  Asn Lys Leu Arg Asp  Leu Leu His Tyr Asp  Arg Lys Leu 
    1055                 1060                 1065             


Lys Asn  Ala Val Ser Lys Ala  Phe Ile Asp Leu Phe  Asp Lys His 
    1070                 1075                 1080             


Gly Met  Ile Leu Lys Leu Lys  Leu Asn Thr Asp His  Gln Leu Glu 
    1085                 1090                 1095             


Val Glu  Ser Leu Glu Pro Lys  Lys Ile Tyr His Leu  Gly Ser Ser 
    1100                 1105                 1110             


Ala Lys  Asp Lys Pro Glu Tyr  Gln Tyr Cys Thr Asn  Gln Val Met 
    1115                 1120                 1125             


Met Ala  Tyr Cys Asn Met Cys  Arg Ser Leu Leu Glu  Met Lys Lys 
    1130                 1135                 1140             


<210>  12
<211>  985
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  12

Leu Glu Lys Asn Lys Ala His Phe Lys Lys Glu Ser Val Asn Asn Thr 
1               5                   10                  15      


Thr Asp Arg Val Lys Gly Asn Asn Lys Lys Ser Leu Phe Tyr Glu Tyr 
            20                  25                  30          


Tyr Arg Asn Ser Ser Lys His Gln Glu Tyr Val Asn Asn Ile Phe Glu 
        35                  40                  45              


Ala Phe Asp Lys Leu Tyr Ser Asn Ser His Glu Asp Ile Asn Asn Leu 
    50                  55                  60                  


Phe Leu Glu Ile Thr Lys Gly Ser Asn Asn Arg Asn Ile Arg Lys Ile 
65                  70                  75                  80  


Arg Glu Val Tyr His Glu Ile Leu Asn Lys Asn Lys Thr Glu Phe Glu 
                85                  90                  95      


Glu Glu Leu Tyr Lys Lys Ile Gln Asp Ser Ile Ser Asn Phe Asp Lys 
            100                 105                 110         


Leu Leu Glu Ile Glu Pro Glu Ile Lys Glu Leu Thr Lys Ser Gln Ile 
        115                 120                 125             


Phe Tyr Lys Tyr Tyr Ile Asp Lys Val Asn Leu Asn Glu Ile Asn Ile 
    130                 135                 140                 


Lys Tyr Cys Phe Cys His Leu Val Glu Ile Glu Val Asn Gln Leu Leu 
145                 150                 155                 160 


Lys Asn Tyr Val Tyr Ser Lys Arg Asn Val Asn Lys Glu Lys Leu Glu 
                165                 170                 175     


Asn Ile Phe Glu Tyr Cys Lys Leu Lys Asn Leu Ile Lys Asn Lys Leu 
            180                 185                 190         


Val Asn Lys Leu Asn Ser Tyr Ile Arg Asn Cys Gly Lys Tyr Asn Gly 
        195                 200                 205             


Tyr Ile Asn Asn Asn Asn Ile Ile Asp Ser Lys Lys Ile Ser Glu Ile 
    210                 215                 220                 


Arg Ile Lys Glu Ala Phe Leu Arg Ser Ile Ile Gly Val Ser Ser Ser 
225                 230                 235                 240 


Ala Tyr Phe Ser Leu Arg Asn Ile Leu Asn Thr Asp Asn Thr Gln Asp 
                245                 250                 255     


Ile Thr Asn Lys Val Lys Gly Glu Val Asp Lys Leu Tyr Gln Glu Asn 
            260                 265                 270         


Lys Lys Ile Glu Leu Glu Glu Arg Leu Lys Leu Phe Phe Gly Asn His 
        275                 280                 285             


Phe Asp Ile Asn Asn Gln Gln Glu Ile Glu Asp Phe Leu Ile Asn Ile 
    290                 295                 300                 


Asp Lys Ile Ile Ser Ser Ile Arg Asn Glu Ile Ile His Phe Lys Ile 
305                 310                 315                 320 


Glu Ala Asn Ala Cys Ser Ile Phe Asp Phe Asn Asn Val Ile Leu Gly 
                325                 330                 335     


Asn Lys Ala Lys Lys Ile Leu Asn Glu Glu Ile Asn Lys Glu Lys Ile 
            340                 345                 350         


Lys Phe Lys Ile Phe Lys Gln Leu Asn Ser Ala Asn Val Phe Asp Tyr 
        355                 360                 365             


Leu Ser Asn Glu Asp Ile Thr Glu Tyr Met Gly Lys Ala Val Phe Ser 
    370                 375                 380                 


Phe Thr Asn Arg Asn Ile Pro Phe Val Pro Ser Phe Thr Lys Ile Tyr 
385                 390                 395                 400 


Asn Arg Val Gln Asp Leu Ala Asn Ser Leu Lys Ile Glu Glu Trp Lys 
                405                 410                 415     


Ile Pro Glu Glu Ser Glu Lys Lys Asp Ala Gln Ile Tyr Leu Leu Lys 
            420                 425                 430         


Asn Ile Tyr Tyr Gly Lys Phe Leu Asp Lys Phe Leu Asn Gln Glu Asp 
        435                 440                 445             


Glu Ile Phe Ile Ser Thr Lys Asp Lys Ile Ile Glu Leu Asn Lys Asn 
    450                 455                 460                 


Gln Asn Lys Arg Thr Gly Phe Tyr Lys Leu Glu Lys Phe Glu Lys Ile 
465                 470                 475                 480 


Glu Glu Thr Asn Pro Lys Lys Tyr Leu Glu Ile Ile Gln Ser Leu Tyr 
                485                 490                 495     


Met Ile Asn Ile Glu Glu Ile Asp Ser Glu Glu Lys Asn Ile Phe Leu 
            500                 505                 510         


Asp Phe Ile Gln Lys Ile Phe Leu Lys Gly Phe Phe Glu Phe Ile Lys 
        515                 520                 525             


Asn Asp Tyr Asn Tyr Leu Leu Lys Leu Glu Arg Val Gln Asp Lys Lys 
    530                 535                 540                 


Asn Val Phe Asp Lys Glu Met Ser Lys Tyr Thr Ala Gly Glu Lys Thr 
545                 550                 555                 560 


Leu Gly Asp Met Glu Glu Ile Asn Glu Ile Thr Gln Lys Ile Lys Val 
                565                 570                 575     


Ala Glu Ile Asp Lys Ile Leu Asn Gln Thr Asp Lys Ile Asn Cys Phe 
            580                 585                 590         


Tyr Leu Leu Leu Lys Leu Leu Asn Tyr Lys Glu Ile Thr Glu Leu Lys 
        595                 600                 605             


Gly Asn Leu Glu Lys Tyr Gln Ile Leu Ser Asn Thr Asn Ile Tyr Lys 
    610                 615                 620                 


Lys Glu Leu Ile Leu Leu Asn Ile Val Asn Leu Asp Asn Asn Lys Val 
625                 630                 635                 640 


Lys Ile Glu Asp Phe Glu Ile Ser Ala Glu Glu Ile Gly Lys Phe Ile 
                645                 650                 655     


Glu Lys Ile Ser Arg Asn Lys Lys Ile Lys Thr Phe Glu Glu Leu Arg 
            660                 665                 670         


Asn Phe Glu Lys Arg Glu Asn Thr Gly Glu Tyr Tyr Asn Val Tyr Ser 
        675                 680                 685             


Asp Asp Lys Asn Ile Lys Asn Met Arg Asn Leu Tyr Asn Ile Lys Lys 
    690                 695                 700                 


Tyr Gly Met Leu Asp Leu Leu Glu Arg Ile Ser Glu Lys Ala Asn Tyr 
705                 710                 715                 720 


Phe Ile Lys Lys Glu Asp Leu Lys Glu Tyr Ser Glu Leu Arg Lys Gln 
                725                 730                 735     


Leu Glu Asp Glu Lys Thr Asp Phe Tyr Lys Ile Gln Lys Asp Leu His 
            740                 745                 750         


Tyr Glu Tyr Gln Lys Lys Tyr Lys Asn Phe Ser Lys Lys Asn Asn Thr 
        755                 760                 765             


Glu Asp Tyr Glu Lys Tyr Lys Glu Ser Ile Glu Asn Ile Glu Lys Tyr 
    770                 775                 780                 


Val His Leu Lys Asn Lys Ile Glu Phe Asn Glu Leu Asn Leu Leu Gln 
785                 790                 795                 800 


Ser Leu Leu Leu Lys Ile Leu His Arg Leu Val Gly Phe Thr Ser Ile 
                805                 810                 815     


Trp Glu Arg Asp Leu Arg Phe Arg Leu Ile Gly Glu Phe Pro Asp Glu 
            820                 825                 830         


Leu Asp Val Glu Asp Ile Phe Asp His Arg Lys Arg Tyr Arg Gly Thr 
        835                 840                 845             


Arg Gly Gln Ile Cys Lys Lys Tyr Asp Gln Phe Ile Ser Val His Ile 
    850                 855                 860                 


Glu Tyr Gln Asn Asn Lys Lys Met Lys Asn Ile Lys Phe Asp Asp Asn 
865                 870                 875                 880 


Asn Pro Ile Arg Asn Tyr Ile Ala His Phe Asn Tyr Leu Pro Thr Pro 
                885                 890                 895     


Lys Tyr Ser Ile Leu Lys Met Leu Gly Lys Leu Arg Glu Leu Leu Asp 
            900                 905                 910         


Tyr Asp Arg Lys Leu Lys Asn Ala Val Met Lys Ser Ile Lys Asp Ile 
        915                 920                 925             


Leu Glu Glu Tyr Gly Phe Lys Ala Glu Phe Val Ile Asn Pro Asp Lys 
    930                 935                 940                 


Glu Ile Ile Leu Asn Ser Val Lys Ser Val Glu Ile Ile His Leu Lys 
945                 950                 955                 960 


Lys Asn Asp Leu Asn Ser His Arg Asn Ser Glu Asp Leu Cys Lys Leu 
                965                 970                 975     


Val Lys Ala Met Leu Glu Tyr Ser Glu 
            980                 985 


<210>  13
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  13

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Gly Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Asn Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Lys Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Ile Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Lys Ile Pro Tyr Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Gly Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Lys 
        915                 920                 925             


Lys Tyr Glu Lys Ala Ile Arg Asn Ile Gln Gln Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Ser Leu Leu Leu 
945                 950                 955                 960 


Arg Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Thr Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Asn Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asp  Thr Glu Lys Ile Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Glu Leu  Lys Lys Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  Asn Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Met Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Ile Met Lys Ser  Ile Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Val Thr Phe Lys  Ile Glu Lys Asp Lys  Lys Ile Arg 
    1100                 1105                 1110             


Ile Glu  Ser Leu Lys Ser Glu  Glu Val Val His Leu  Lys Lys Leu 
    1115                 1120                 1125             


Lys Leu  Lys Asp Asn Asp Lys  Lys Lys Glu Pro Ile  Lys Thr Tyr 
    1130                 1135                 1140             


Arg Asn  Ser Lys Glu Leu Cys  Lys Leu Val Lys Val  Met Phe Glu 
    1145                 1150                 1155             


Tyr Lys  Ile Lys Glu Lys Lys  Ser Glu Asn 
    1160                 1165             


<210>  14
<211>  923
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  14

Leu Lys Gln Ile Tyr Asn Leu Glu Leu Lys Lys Tyr Ile Glu Asn Asn 
1               5                   10                  15      


Phe Ser Tyr Lys Lys Gln Lys Ser Lys Ser Lys Asn Gly Lys Asn Asp 
            20                  25                  30          


Tyr Leu Tyr Leu Asn Phe Leu Lys Lys Ile Met Phe Ile Glu Glu Val 
        35                  40                  45              


Asp Glu Lys Lys Glu Ile Asn Lys Glu Lys Phe Lys Asn Lys Ile Asn 
    50                  55                  60                  


Ser Asn Phe Lys Asn Leu Phe Val Gln His Ile Leu Asp Tyr Gly Lys 
65                  70                  75                  80  


Leu Leu Tyr Tyr Lys Glu Asn Asp Glu Tyr Ile Lys Asn Thr Gly Gln 
                85                  90                  95      


Leu Glu Thr Lys Asp Leu Glu Tyr Ile Lys Thr Lys Glu Thr Leu Ile 
            100                 105                 110         


Arg Lys Met Ala Val Leu Val Ser Phe Ala Ala Asn Ser Tyr Tyr Asn 
        115                 120                 125             


Leu Phe Gly Arg Thr Glu Asn Asn Ile Leu Thr Gln Glu Ile Ser Asp 
    130                 135                 140                 


Asp Leu Leu Leu Gly Lys Ile Glu Asn Glu Ile Tyr Ile Lys Gly Glu 
145                 150                 155                 160 


Lys Asn Arg Arg Tyr Val Phe Lys Glu Lys Met Leu Asn Tyr Phe Phe 
                165                 170                 175     


Asn Pro Glu Ile Phe Gly Asp Asn Lys Ile Val Glu Val Leu Ser Ala 
            180                 185                 190         


Ile Ser Ser Ser Ile Tyr Asn Ile Arg Asn Gly Val Asn His Phe Asp 
        195                 200                 205             


Lys Met Val Leu Gly Lys Tyr Asn Asn Glu Leu Asp Leu Lys Asp Ser 
    210                 215                 220                 


Asp Thr Ile Lys Asp Tyr Phe Asn Phe Lys Lys Lys Glu Ile Gln Gln 
225                 230                 235                 240 


Asp Leu Lys Asp Arg Phe Ile Ser Asn Asn Leu Gln Tyr Tyr Tyr Thr 
                245                 250                 255     


Glu Asn Glu Ile Lys Lys Tyr Phe Glu Lys Tyr Lys Phe Glu Ile Leu 
            260                 265                 270         


Lys Thr Lys Ala Ser Phe Ala Pro Asn Phe Lys Arg Ile Leu Ile Lys 
        275                 280                 285             


Gly Glu Asn Leu Ser Ile Ser Glu Ser Asn Asn Ser Tyr Glu Phe Phe 
    290                 295                 300                 


Lys Thr Tyr Ser Glu Ser Ser Asp Lys Asn Thr Glu Tyr Asn Glu Phe 
305                 310                 315                 320 


Met Lys Thr Arg Asn Phe Leu Leu Lys Glu Leu Tyr Tyr Asn Asn Phe 
                325                 330                 335     


Tyr Thr Glu Phe Leu Asn Asn Lys Ala Lys Phe Arg Glu Ala Val Glu 
            340                 345                 350         


Lys Val Lys Lys Asn Lys Lys Arg Arg Gly Gly Lys Ser Tyr Asp Val 
        355                 360                 365             


Ile Gly Asn Tyr Asn Phe Ser Asp Ser Ile Ser Glu Tyr Ile Ser Tyr 
    370                 375                 380                 


Ile His Lys Ser Glu Met Glu Arg Ile Glu Ile Asn Thr Glu Lys Asn 
385                 390                 395                 400 


Arg Lys Asp Thr Ser Lys His Ile Arg Asp Phe Ile Glu Glu Ile Phe 
                405                 410                 415     


Leu Glu Gly Phe Ile Glu Tyr Leu Asn Asn Asn Asn Phe Lys Phe Leu 
            420                 425                 430         


Lys Asn Arg Asn Glu Val Asp Lys Glu Arg Glu Glu Ile Val Arg Asn 
        435                 440                 445             


Leu Asn Ile Arg Ile Glu Gly Leu Asp Ile Leu Asn Glu Asp Asp Ser 
    450                 455                 460                 


Glu Ile Leu Asn Leu Tyr Leu Phe Phe Asn Met Ile Asp Asn Lys Arg 
465                 470                 475                 480 


Ile Ser Glu Phe Arg Asn Asp Met Ile Lys Tyr Lys Gln Phe Leu Ala 
                485                 490                 495     


Lys Arg Gln Asn Ile Asp Ser Lys Phe Leu Lys Ile Asp Ile Glu Lys 
            500                 505                 510         


Ile Glu Ala Ile Ile Glu Phe Val Ile Ile Thr Lys Glu Lys Leu Glu 
        515                 520                 525             


Ile Leu Glu Gly Glu Thr Lys Glu Gln Lys Lys Asp Asn Met Asn Ala 
    530                 535                 540                 


Leu Phe Asn Lys Phe Tyr Ser Ser Glu Ser Glu Tyr Asp Glu Lys Leu 
545                 550                 555                 560 


Lys Lys Phe Ile Glu Glu Ala Ile Leu Gly Asp Lys Lys Asn Thr Pro 
                565                 570                 575     


Phe Tyr Ser Thr Asp Gly Lys Thr Pro Ile Val His Ser Lys Leu Glu 
            580                 585                 590         


Lys Met Arg Lys Tyr Gly Thr Glu Asn Phe Leu Ser Lys Val Leu Lys 
        595                 600                 605             


Asn Ser Lys Tyr Thr Leu Asn Asn Met Thr Ala Lys Glu Lys Phe Glu 
    610                 615                 620                 


Ala Glu Val Ser Asp Glu Leu Lys Glu Tyr Lys Ile Leu Glu Lys Val 
625                 630                 635                 640 


Ser Arg Phe Lys Glu Lys Gly Lys Pro Lys Lys Val Ile Glu Tyr Tyr 
                645                 650                 655     


Asn Asp Cys Arg Cys Tyr Leu His Lys Lys Trp Ile Glu Lys Lys Lys 
            660                 665                 670         


Ser Glu Glu Glu Phe Glu His Lys Glu Ile Tyr Lys Lys Ile Ile Glu 
        675                 680                 685             


Glu Ile Arg Lys Tyr Asn Tyr Leu Glu Asn Lys Glu Lys Leu Gln Asn 
    690                 695                 700                 


Val Tyr Leu Leu His Glu Met Leu Ser Asp Leu Leu Ala Arg Asn Val 
705                 710                 715                 720 


Ala Phe Phe Asn Lys Trp Glu Arg Asp Phe Lys Phe Ile Val Ile Ala 
                725                 730                 735     


Ile Lys Gln Phe Leu Arg Glu Asn Asp Lys Glu Lys Val Asn Glu Phe 
            740                 745                 750         


Leu Asn Pro His Lys Ser Asp Gly Ser Arg Asp Asn Phe Ser Val Thr 
        755                 760                 765             


Asn Tyr Arg Ser Lys Met Lys Ser Ile Ile Asn Asn Ile His Glu Asn 
    770                 775                 780                 


Phe Met Ser Leu Leu Phe Leu Asn Asn Asn Leu Ala Thr Gly Gly Ile 
785                 790                 795                 800 


Gln Val Gly Arg Asn Asn Asn Phe Thr Trp Gly Ala Leu Arg Asn Tyr 
                805                 810                 815     


Ile Ala His Phe Glu Tyr Leu His Glu Glu Lys Asp Thr Ile Ser Phe 
            820                 825                 830         


Ile Gly Gln Ala Asn Leu Leu Ile Lys Leu Phe Ser Tyr Asp Lys Lys 
        835                 840                 845             


Val Gln Asn His Ile Leu Lys Ser Ile Lys Thr Leu Leu Glu Lys Tyr 
    850                 855                 860                 


Asn Ile Gln Ile Asn Phe Glu Ile Pro Lys Asp Glu Asp Lys Asn Glu 
865                 870                 875                 880 


Thr Phe Arg Tyr Lys Ile Lys Asn Gln Leu Tyr Ser Lys Lys Gly Lys 
                885                 890                 895     


Met Leu Gly Lys Asn Asn Glu Phe Glu Ile Leu Glu Lys Glu Phe Leu 
            900                 905                 910         


Glu Asn Val Lys Ala Met Leu Glu Tyr Leu Glu 
        915                 920             


<210>  15
<211>  1425
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  15

Met Lys Leu Ser Lys Val Asp Arg Ile Arg Val Ala Val Gly Lys Thr 
1               5                   10                  15      


Gly Lys Thr Glu Asn Gly Asn Ser Gln Gly Arg Gly Val Leu Tyr Arg 
            20                  25                  30          


Ser Pro Lys Gly Asn Lys Thr Val Ala Val Asp Ala Val Val Glu Glu 
        35                  40                  45              


Arg Ile Arg Asn Ala Asn Arg Leu Tyr Ser Ala Phe Phe Arg Cys Ala 
    50                  55                  60                  


Tyr Pro Glu Glu Pro Glu Arg His Phe Glu Glu Ile Ile Lys Arg Met 
65                  70                  75                  80  


Ala Thr Gly Lys Lys Ser Gly Ala Gln Ile Leu Lys Glu Tyr Ile Gly 
                85                  90                  95      


Tyr Glu Gly Gln Lys Asn Arg Lys Pro Tyr Thr Phe Tyr Val Asn Lys 
            100                 105                 110         


Cys Ala Tyr Arg Pro Ala Gly Lys Glu Leu Gly Gln Val Leu Arg Leu 
        115                 120                 125             


Phe Val Lys Glu Arg Leu Gly Gln Asn Trp Gln Asn Pro Glu Ala Ala 
    130                 135                 140                 


Glu Ala Ala Val Ala Leu Leu Thr Cys Leu Cys Glu Gly Lys Thr Asn 
145                 150                 155                 160 


Arg Tyr Thr Glu Asn Thr Ala Asp Gly Pro Val Leu Thr Glu Leu Ser 
                165                 170                 175     


Glu Gln Thr Val Thr Gln Leu Glu Gln Val Ser Arg Leu Gly Gly Ser 
            180                 185                 190         


Ile Leu Val Pro Lys Thr Glu Arg Leu Glu Thr Ile Val Thr Val Ile 
        195                 200                 205             


Leu Arg Leu Thr Ala Glu Gln Cys Asn Thr Ser Leu Tyr Val Asn Gly 
    210                 215                 220                 


Gly Thr Lys Glu Ala Gln Asp Ala Asp Leu Glu Lys Gln Ile Ala Leu 
225                 230                 235                 240 


Leu Lys Ser Leu Gln Thr Lys Pro Leu Leu Leu Lys Glu Arg Phe Asp 
                245                 250                 255     


Lys Val Thr Lys Gln Thr Ile Arg Asp Glu Gln Lys Leu Ser Glu Phe 
            260                 265                 270         


Ser Tyr Lys Asp Ala Thr Lys Glu Arg Met Glu Ala Val Val Val Arg 
        275                 280                 285             


Met Arg Lys Thr Leu Lys Lys Gly Ala Ser Arg Glu Val Ala Val Glu 
    290                 295                 300                 


Leu Leu Gln Ala Leu Ala Gln Tyr Asp Gly Lys Thr Trp Asp Gly Trp 
305                 310                 315                 320 


Leu Thr Gln Met Leu Glu Thr Glu Ala Ser Lys Lys Lys Leu Lys Asp 
                325                 330                 335     


Phe Ile Leu Ala Val Asn Lys Asp Phe His His Phe His Val Ile Lys 
            340                 345                 350         


Ser Val Lys Asn Thr Ala Val Ala Val Ser His Ser Glu Asp Asn Thr 
        355                 360                 365             


Leu Gln Leu Ser Gly Ala Lys Lys Lys Thr Lys Gly Ala Met Gln Asp 
    370                 375                 380                 


Ala Leu Phe Ala Tyr Ala Gln Ser Glu Glu Ser Ser Asp Glu Thr Leu 
385                 390                 395                 400 


His Arg Ile Lys Arg Ile Leu Phe Thr Tyr Val Leu Gly Gly Arg Gln 
                405                 410                 415     


Asp Asn Thr Leu Arg Leu Thr Glu Lys Thr His Leu Ala Lys Glu Leu 
            420                 425                 430         


Leu Trp Lys Phe Arg Gly Thr Gly Ala Gly Leu Phe Asp Ala Asp Phe 
        435                 440                 445             


Val Pro Glu Glu Glu Arg Ala Gly Glu Ser Gly Arg Lys Ala Gly Ser 
    450                 455                 460                 


Tyr Thr Asp Leu Gly Cys Leu Phe Ala Glu Asp Asp Gly Ile Arg Asn 
465                 470                 475                 480 


Gln Arg Arg Ile Ala Asp Arg Ile Asn Tyr Val Asn Tyr Gly Asn Tyr 
                485                 490                 495     


Leu Arg Met Arg Lys Ala Ala Glu Asp Glu Phe Thr Leu Phe Trp Cys 
            500                 505                 510         


Ala Tyr Ile Lys Asp Tyr Ile Glu Glu Asn Tyr Val Thr Lys Ile Arg 
        515                 520                 525             


Glu Ala Lys Arg Thr Gly Gly Lys Arg Arg Leu Lys Glu Thr Asp Cys 
    530                 535                 540                 


Glu Ala Glu Arg Met Met Glu Lys Cys Trp His Asp Ile Ile Arg Tyr 
545                 550                 555                 560 


Ile Cys Gly Lys Tyr Ile His Ile Gly Lys Ala Val Tyr His Phe Ala 
                565                 570                 575     


Ile Pro Glu Asp Leu Leu Ala Asn Pro Gly Glu Val Arg Ser Phe Gly 
            580                 585                 590         


Asp Val His Ala Lys Tyr Ala Asp Gly Ile Thr Ser Phe Asp Tyr Glu 
        595                 600                 605             


Asp Ile Lys Ala Glu Glu Asn Leu Gln Lys Ser Ile Phe Asn Val Leu 
    610                 615                 620                 


Val Ser Ala Val Ala Asn Tyr Ser Arg Ser Val Val Asp Leu Ser Ser 
625                 630                 635                 640 


Glu Arg Ala Glu Glu Leu Arg Arg Leu Pro Gly Asn Glu Arg Leu Asn 
                645                 650                 655     


Glu Asp Val Leu Met Met Lys Glu Thr His Leu Lys Glu Leu Leu Leu 
            660                 665                 670         


Pro Asp Ala Lys Lys Arg Leu Leu Arg Tyr Phe Gly Gly Tyr Ser Ala 
        675                 680                 685             


Cys Glu Gly Leu Ser Gly Val Thr Ser Glu Glu Leu Ala Trp Glu Met 
    690                 695                 700                 


Arg Thr Val Leu Ser Thr Leu Arg Asn Glu Ser Phe His Tyr Thr Phe 
705                 710                 715                 720 


Gly Lys Lys Lys Lys Leu Asp Tyr Lys Val Ala Lys Gln Leu Trp Met 
                725                 730                 735     


Gln Ala Ile Arg Ala Asn Arg Gln Leu Ile Leu Asp Lys Tyr Tyr Ser 
            740                 745                 750         


Asn Asn Thr Cys Arg Tyr Tyr Ser Pro Asn Ser Ile Lys Ala Leu Ile 
        755                 760                 765             


Glu Gln Gly Tyr Arg Ser Tyr Glu Glu Arg Glu Ala Gln Ile Pro Ala 
    770                 775                 780                 


Phe Lys Thr Val Trp Lys Lys Ala Glu Leu Ala Lys Tyr Leu Ala Asp 
785                 790                 795                 800 


Lys Lys Val Met Pro Ala Glu Ile Ser Gly Glu Glu Lys Glu Arg Val 
                805                 810                 815     


Ile Phe Gln Gly Ala Phe Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg 
            820                 825                 830         


Glu Phe Thr Val Gly Asn Thr Ala Ala Lys Tyr Phe Phe Asp Ala Val 
        835                 840                 845             


Glu Arg Tyr Cys Lys Glu Asn Glu Thr Gly Pro Tyr Lys Asn Pro Ala 
    850                 855                 860                 


Lys Ser Phe Asn Asp Tyr Val Asn Gly Ala Phe Asn Asn Lys Gly Val 
865                 870                 875                 880 


Lys Val Gln Lys Gly Leu Ser Asp Leu Tyr Arg Glu Gly Lys Ile Thr 
                885                 890                 895     


Phe Gly Val Val Cys Gln Thr Ile Met Ala Glu Tyr Thr Gln Gln Asn 
            900                 905                 910         


Glu Lys Ser Glu Gly Glu Ala Ile Tyr Gln His Phe Lys Met Leu Phe 
        915                 920                 925             


Pro Leu Cys Met Arg Lys Gly Phe Gln Lys Tyr Val Glu Glu Lys His 
    930                 935                 940                 


Lys Glu Leu Leu Gln Pro Val Ile Arg Glu Met Gly Ser Arg Glu Asp 
945                 950                 955                 960 


Phe Leu Thr Asn Ile His Ile Gly Cys Phe Asp Asp Phe Cys Arg Glu 
                965                 970                 975     


Asp Gly Met Tyr Glu Tyr Asp Trp Phe Val Val Ala His Leu Ile His 
            980                 985                 990         


Pro Lys Arg Leu Asn Glu Leu Val  Gly Asn Leu Lys Asp  Tyr Met Gln 
        995                 1000                 1005             


Phe Lys  Gln Asp Ile Leu Arg  Arg Ala Asp Tyr Val  Glu Gln Phe 
    1010                 1015                 1020             


Thr Lys  Glu Glu Leu Ala Ala  Met Lys Ala Arg Thr  Glu Glu Lys 
    1025                 1030                 1035             


Leu Gln  Lys Ile Ser Gly Ile  Leu Arg Val Ala Glu  Phe Val Arg 
    1040                 1045                 1050             


Gly Ile  Ala Gly Arg Val Ser  Asn Thr Phe Ser Asp  Tyr Tyr Glu 
    1055                 1060                 1065             


Ser Glu  Glu Ala Tyr Ala Ser  Tyr Leu Glu Gln Tyr  Ile Glu Phe 
    1070                 1075                 1080             


Pro Arg  Ile Lys Gly Ser Thr  Val Phe Glu Ser Phe  Arg Asp Phe 
    1085                 1090                 1095             


Cys Val  Asn Thr Leu Pro Gly  Gly Ala Val Met Asp  Val Tyr Met 
    1100                 1105                 1110             


Asp Glu  Lys Asn Pro Arg Ile  Leu Arg Asn Val Glu  Val Ala Arg 
    1115                 1120                 1125             


Met Tyr  Ala Gly Gly Asp Ile  Gly Leu Arg Thr Arg  Lys Lys Val 
    1130                 1135                 1140             


Thr Ala  Glu Glu Leu Lys Arg  Tyr Tyr Gln Asn Glu  Ala Glu Val 
    1145                 1150                 1155             


Ala Ala  Leu Leu Lys Ala Gly  Leu Cys Ala Thr Ala  Glu Asp Gln 
    1160                 1165                 1170             


Lys Arg  Val Lys Ala Gln Gln  Glu Leu Arg Asn Arg  Ile Thr Leu 
    1175                 1180                 1185             


Thr Asp  Val Thr Glu Ile Gln  Glu Val Ile Asn Asp  Leu Leu Ser 
    1190                 1195                 1200             


Gln Leu  Val Thr Phe Ser Tyr  Phe Arg Glu Arg Asp  Glu Met Tyr 
    1205                 1210                 1215             


Leu Leu  Leu Gly Phe Tyr Tyr  Met Ala Leu Gln Ser  Asp Gly Asp 
    1220                 1225                 1230             


Trp Gly  Glu Glu Leu Arg Val  Phe Asp Gly Lys Lys  Leu Gln Val 
    1235                 1240                 1245             


Glu Asn  Gly Phe Val Leu Tyr  Gln Leu Leu Ser Ala  Phe Thr Tyr 
    1250                 1255                 1260             


Gly Leu  Asn Met Tyr Ser Glu  Ala Ala Pro Asp Gly  Lys Gly Gly 
    1265                 1270                 1275             


Ser Gln  Ala Gly Lys Ile Gly  Glu Phe Ile Lys Ala  His Pro Asn 
    1280                 1285                 1290             


Ser Trp  Asp Arg Ala Leu Arg  Leu Phe Val Asp Asp  Gly Ala Cys 
    1295                 1300                 1305             


Glu Glu  Val Ser Arg Lys Ala  Arg Asn Tyr Val Asp  His Phe Arg 
    1310                 1315                 1320             


Tyr Tyr  Val Lys Pro Asp Arg  Ser Ile Met Asp Leu  Tyr Ala Val 
    1325                 1330                 1335             


Tyr His  Glu Tyr Phe Phe Asp  Tyr Ser Thr Lys Met  Arg Lys Ser 
    1340                 1345                 1350             


Val Leu  Gln Asn Phe Ala Ser  Ile Leu Glu Arg Tyr  Phe Val Leu 
    1355                 1360                 1365             


Thr Lys  Phe Lys Leu Gly Gly  Glu Arg Gly Ala Gln  Thr Leu Glu 
    1370                 1375                 1380             


Ala Glu  Leu Ser Gly Asp Lys  Phe Thr Tyr Lys Leu  Ser Asp Thr 
    1385                 1390                 1395             


Lys Ala  Lys Pro Val Val Leu  Pro Ala Arg Asn Lys  Glu Phe Leu 
    1400                 1405                 1410             


Glu Asn  Leu Lys Asn Glu Leu  Asn Tyr Arg Gln Glu  
    1415                 1420                 1425 


<210>  16
<211>  1212
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  16

Met Lys Ile Thr Lys Ile Asp Gly Val Ser His Tyr Lys Lys Gln Asp 
1               5                   10                  15      


Lys Gly Ile Leu Lys Lys Lys Trp Arg Asp Leu Asp Glu Gly Lys Gln 
            20                  25                  30          


Arg Glu Lys Ile Glu Ala Arg Tyr Asn Lys Gln Ile Glu Ser Lys Ile 
        35                  40                  45              


Tyr Lys Glu Phe Phe Arg Leu Lys Ser Gly Lys Asp Ser Glu Arg Ile 
    50                  55                  60                  


Thr Lys Glu Lys Asn Glu Gly Ile Lys Ser Leu Tyr Tyr Leu Ile Lys 
65                  70                  75                  80  


Glu Leu Tyr Glu Gly Lys Glu Asn Asp Leu Trp Glu Leu Lys Asn Ile 
                85                  90                  95      


Asn Leu Glu Ile Leu Gly Asp Lys Glu Arg Ile Ile Lys Gly Tyr Lys 
            100                 105                 110         


Phe Lys Glu Asp Val Tyr Phe Phe Lys Glu Gly Asp Lys Glu Tyr Tyr 
        115                 120                 125             


Leu Arg Thr Leu Phe Asn Asn Leu Ile Glu Lys Val Gln Asn Glu Asn 
    130                 135                 140                 


Arg Glu Lys Val Arg Lys Asn Lys Glu Phe Leu Asp Leu Lys Glu Ile 
145                 150                 155                 160 


Phe Lys Lys Tyr Lys Asp Arg Lys Ile Asp Leu Leu Leu Lys Ser Ile 
                165                 170                 175     


Asn Asn Asn Lys Ile Asn Leu Glu Tyr Lys Lys Glu Asn Val Asn Glu 
            180                 185                 190         


Glu Ile Tyr Gly Ile Asn Pro Thr Asn Asp Arg Glu Met Ile Phe Tyr 
        195                 200                 205             


Glu Leu Leu Lys Glu Ile Ile Glu Lys Lys Asp Glu Gln Lys Ser Ile 
    210                 215                 220                 


Leu Glu Glu Lys Leu Asp Asn Phe Asp Ile Thr Asn Phe Leu Glu Asn 
225                 230                 235                 240 


Ile Glu Lys Ile Phe Asn Glu Glu Thr Glu Ile Asn Ile Ile Lys Gly 
                245                 250                 255     


Lys Val Leu Asn Glu Leu Arg Glu Tyr Ile Lys Glu Lys Glu Glu Asn 
            260                 265                 270         


Asn Ser Asp Asn Lys Leu Lys Gln Ile Tyr Asn Leu Glu Leu Lys Lys 
        275                 280                 285             


Tyr Ile Glu Asn Asn Phe Ser Tyr Lys Lys Gln Lys Ser Lys Ser Lys 
    290                 295                 300                 


Asn Gly Lys Asn Asp Tyr Leu Tyr Leu Asn Phe Leu Lys Lys Ile Met 
305                 310                 315                 320 


Phe Ile Glu Glu Val Asp Glu Lys Lys Glu Ile Asn Lys Glu Lys Phe 
                325                 330                 335     


Lys Asn Lys Ile Asn Ser Asn Phe Lys Asn Leu Phe Val Gln His Ile 
            340                 345                 350         


Leu Asp Tyr Gly Lys Leu Leu Tyr Tyr Lys Glu Asn Asp Glu Tyr Ile 
        355                 360                 365             


Lys Asn Thr Gly Gln Leu Glu Thr Lys Asp Leu Glu Tyr Ile Lys Thr 
    370                 375                 380                 


Lys Glu Thr Leu Ile Arg Lys Met Ala Val Leu Val Ser Phe Ala Ala 
385                 390                 395                 400 


Asn Ser Tyr Tyr Asn Leu Phe Gly Arg Thr Glu Asn Asn Ile Leu Thr 
                405                 410                 415     


Gln Glu Ile Ser Asp Asp Leu Leu Leu Gly Lys Val Glu Asn Glu Arg 
            420                 425                 430         


Tyr Ile Lys Gly Glu Arg Asn Arg Arg Tyr Val Phe Lys Glu Lys Ile 
        435                 440                 445             


Leu Asn Tyr Phe Phe Asn Ser Glu Ile Phe Gly Asp Asn Lys Ile Val 
    450                 455                 460                 


Glu Val Leu Asn Ala Ile Ser Ser Ser Ile Tyr Asn Ile Arg Asn Gly 
465                 470                 475                 480 


Val Asn His Phe Asp Lys Met Ile Leu Gly Lys Tyr Asn Asn Gly Leu 
                485                 490                 495     


Asp Leu Lys Asp Ser Asp Thr Ile Lys Asp Tyr Phe Asn Phe Lys Lys 
            500                 505                 510         


Lys Glu Ile Gln Gln Asp Leu Lys Asp Arg Phe Ile Ser Asn Asn Leu 
        515                 520                 525             


Gln Tyr Tyr Tyr Thr Glu Asn Glu Ile Lys Lys Tyr Phe Glu Lys Tyr 
    530                 535                 540                 


Lys Phe Glu Ile Leu Lys Thr Lys Ala Ser Phe Ala Pro Asn Phe Lys 
545                 550                 555                 560 


Arg Ile Leu Ile Lys Gly Glu Asn Leu Ser Ile Ser Glu Ser Asn Asn 
                565                 570                 575     


Ser Tyr Glu Phe Phe Lys Ala Tyr Ser Glu Ser Ser Asp Lys Asn Thr 
            580                 585                 590         


Glu Tyr Asn Glu Phe Met Lys Thr Arg Asn Phe Leu Leu Lys Glu Leu 
        595                 600                 605             


Tyr Tyr Asn Asn Phe Tyr Thr Glu Phe Leu Asn Asp Lys Ala Lys Phe 
    610                 615                 620                 


Arg Glu Ala Val Glu Lys Val Lys Lys Asn Lys Lys Arg Arg Gly Gly 
625                 630                 635                 640 


Lys Ser Tyr Asp Val Ile Gly Asn Tyr Asn Phe Ser Asp Ser Ile Ser 
                645                 650                 655     


Glu Tyr Ile Ser Tyr Ile His Lys Ser Glu Met Glu Arg Ile Glu Ile 
            660                 665                 670         


Asn Thr Glu Lys Asn Arg Lys Asp Thr Ser Lys His Ile Arg Asp Phe 
        675                 680                 685             


Ile Glu Glu Ile Phe Leu Glu Gly Phe Ile Glu Tyr Leu Asp Asn Asn 
    690                 695                 700                 


Asn Phe Lys Phe Leu Lys Asn Arg Asn Glu Val Asn Lys Glu Arg Glu 
705                 710                 715                 720 


Glu Ile Val Arg Asn Leu Asn Ile Gln Ile Glu Gly Leu Asp Ile Leu 
                725                 730                 735     


Asn Glu Asp Asp Ser Glu Ile Leu Asn Leu Tyr Leu Phe Phe Asn Met 
            740                 745                 750         


Ile Asp Asn Lys Arg Ile Ser Glu Phe Arg Asn Asp Met Ile Lys Tyr 
        755                 760                 765             


Lys Gln Phe Leu Ala Lys Arg Gln Asn Ile Asp Ser Lys Phe Leu Lys 
    770                 775                 780                 


Ile Asp Ile Glu Lys Ile Glu Ala Ile Ile Glu Phe Val Ile Ile Thr 
785                 790                 795                 800 


Lys Glu Lys Leu Glu Ile Leu Glu Gly Glu Thr Lys Glu Gln Lys Lys 
                805                 810                 815     


Asp Asn Met Asn Ala Leu Phe Asn Lys Phe Tyr Ser Ser Glu Ser Glu 
            820                 825                 830         


Tyr Asp Glu Ser Leu Lys Lys Phe Ile Glu Glu Ile Val Leu Asn Asp 
        835                 840                 845             


Lys Lys Asn Thr Pro Phe Tyr Ser Thr Asp Gly Lys Thr Pro Ile Val 
    850                 855                 860                 


His Ser Asn Leu Glu Lys Met Arg Lys Tyr Gly Thr Glu Asn Phe Leu 
865                 870                 875                 880 


Ser Lys Val Leu Lys Asp Ser Lys Tyr Ile Leu Asn Asn Met Thr Thr 
                885                 890                 895     


Lys Glu Lys Phe Glu Ala Glu Val Ser Asp Glu Leu Lys Glu Tyr Lys 
            900                 905                 910         


Ile Leu Glu Lys Val Ser Arg Phe Lys Glu Asn Glu Lys Pro Lys Lys 
        915                 920                 925             


Val Ile Glu Tyr Tyr Asn Asp Cys Arg Cys Tyr Leu His Lys Glu Trp 
    930                 935                 940                 


Ile Glu Lys Lys Lys Ser Lys Glu Lys Phe Glu His Lys Glu Trp Ile 
945                 950                 955                 960 


Glu Asn Lys Lys Asn Lys Glu Glu Phe Glu His Lys Glu Ile Tyr Lys 
                965                 970                 975     


Lys Ile Ile Glu Glu Ile Arg Lys Tyr Asn Tyr Leu Glu Asn Lys Glu 
            980                 985                 990         


Lys Leu Gln Asn Val Tyr Leu Leu  His Glu Met Leu Ser  Asp Leu Leu 
        995                 1000                 1005             


Ala Arg  Asn Val Ala Phe Leu  Asn Lys Trp Glu Arg  Asp Phe Lys 
    1010                 1015                 1020             


Phe Ile  Val Ile Ala Ile Lys  Gln Phe Leu Arg Glu  Asn Asp Lys 
    1025                 1030                 1035             


Glu Lys  Val Asp Glu Phe Leu  Asn Pro Tyr Lys Ser  Asp Gly Ser 
    1040                 1045                 1050             


Arg Asp  Asn Phe Ser Val Thr  Asn Tyr Arg Ser Lys  Met Arg Leu 
    1055                 1060                 1065             


Val Ile  Asn Asn Ile His Glu  Asn Phe Met Ser Leu  Leu Phe Leu 
    1070                 1075                 1080             


Asn Asp  Asn Leu Ala Ile Arg  Glu Ile Thr Ala Asn  Asn Phe Thr 
    1085                 1090                 1095             


Trp Val  Asn Leu Arg Asn Tyr  Ile Ala His Phe Glu  Tyr Leu His 
    1100                 1105                 1110             


Glu Glu  Lys Asp Thr Ile Ser  Phe Ile Val Gln Ala  Asn Leu Leu 
    1115                 1120                 1125             


Ile Lys  Leu Phe Ser Tyr Asp  Lys Lys Val Gln Asn  His Ile Leu 
    1130                 1135                 1140             


Lys Ser  Ile Lys Thr Leu Leu  Glu Lys Tyr Asn Ile  Gln Ile Ser 
    1145                 1150                 1155             


Phe Lys  Ile Pro Lys Asp Glu  Asp Lys Asn Glu Thr  Phe Arg Tyr 
    1160                 1165                 1170             


Glu Ile  Lys Asn Gln Leu Tyr  Ser Lys Lys Gly Lys  Met Leu Gly 
    1175                 1180                 1185             


Lys Asn  Asn Lys Phe Glu Ile  Leu Glu Asn Glu Phe  Leu Glu Asn 
    1190                 1195                 1200             


Val Lys  Ala Met Leu Glu Tyr  Ser Lys 
    1205                 1210         


<210>  17
<211>  1405
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  17

Leu Phe Leu Trp Ile Ile Glu Glu Val Ile Tyr Glu Ile Ile Lys Leu 
1               5                   10                  15      


Tyr Lys Asn Leu Glu Glu Glu Ile Ile Met Gly Asn Leu Phe Gly Tyr 
            20                  25                  30          


Lys Arg Trp Tyr Glu Val Arg Asp Lys Glu Asp Tyr Lys Ile Lys Arg 
        35                  40                  45              


Lys Val Lys Val Lys Arg Asn Tyr Asp Gly Asn Lys Tyr Ile Leu Asn 
    50                  55                  60                  


Ile Asn Glu Asn Asn Asn Lys Glu Lys Ile Asp Asp Asn Lys Phe Ile 
65                  70                  75                  80  


Arg Glu Phe Ile Asn Tyr Lys Lys Asn Asp Asn Val Leu Arg Glu Phe 
                85                  90                  95      


Lys Lys Lys Phe His Ala Gly Asn Ile Leu Phe Lys Leu Lys Gly Lys 
            100                 105                 110         


Glu Lys Ile Arg Arg Ile Glu Asn Asp Asp Asp Phe Leu Glu Thr Glu 
        115                 120                 125             


Glu Val Val Leu Tyr Ile Glu Val Tyr Gly Gln Ser Glu Lys Leu Lys 
    130                 135                 140                 


Asn Glu Glu Glu Ile Thr Lys Lys Asp Ile Leu Lys Glu Ile Asn Lys 
145                 150                 155                 160 


Gln Lys Ile Asp Asn Ser Val Lys Lys Ile Ser Met Asn Thr Asn Ser 
                165                 170                 175     


Gly Lys Thr Ile Val Ile Asn Phe Ser Asp Lys Leu Lys Lys Asp Lys 
            180                 185                 190         


Asp Asp Tyr Gln Ile Thr Leu Asn Ile Ile Ser Glu Asp Glu Leu Glu 
        195                 200                 205             


Arg Lys Arg Lys Ile Tyr Asp Ile Phe Lys Met Ile Asn Met Asp Leu 
    210                 215                 220                 


Tyr Gln Ile Ile Lys Glu Ile Ile Glu Asn Glu Val Gln Lys Val Phe 
225                 230                 235                 240 


Glu Asn Arg Tyr Tyr Glu Glu Tyr Leu Arg Glu Lys Leu Leu Lys Asp 
                245                 250                 255     


Asp Lys Ile Asp Val Ile Leu Thr Asn Phe Met Glu Ile Arg Glu Lys 
            260                 265                 270         


Ile Lys Ser Asn Leu Glu Ile Met Gly Phe Val Lys Phe Tyr Leu Asn 
        275                 280                 285             


Val Gly Gly Asp Lys Lys Lys Ser Glu Asn Lys Lys Met Phe Val Glu 
    290                 295                 300                 


Lys Ile Leu Asn Ile Asn Val Asp Leu Thr Val Glu Asp Ile Val Asp 
305                 310                 315                 320 


Phe Ile Val Lys Glu Leu Lys Phe Trp Asn Ile Thr Lys Arg Ile Glu 
                325                 330                 335     


Lys Val Lys Glu Phe Asn Asn Lys Phe Leu Glu Asn Lys Arg Asn Arg 
            340                 345                 350         


Thr Tyr Ile Lys Ser Tyr Val Leu Leu Asp Lys His Glu Lys Phe Lys 
        355                 360                 365             


Ile Glu Arg Glu Asn Lys Lys Asp Lys Ile Val Lys Phe Phe Val Glu 
    370                 375                 380                 


Asn Ile Lys Asn Asn Ser Ile Lys Glu Lys Ile Glu Lys Ile Leu Thr 
385                 390                 395                 400 


Glu Phe Lys Ile Asp Glu Leu Thr Lys Lys Leu Glu Lys Glu Leu Lys 
                405                 410                 415     


Lys Gly Asn Cys Asp Thr Glu Ile Phe Gly Ile Phe Lys Lys His Tyr 
            420                 425                 430         


Lys Val Asn Phe Asp Ser Lys Lys Phe Ser Asn Lys Ser Asp Glu Glu 
        435                 440                 445             


Lys Glu Leu Tyr Lys Ile Ile Tyr Arg Tyr Leu Lys Gly Arg Ile Glu 
    450                 455                 460                 


Lys Ile Leu Ile Asn Glu Gln Lys Val Arg Leu Lys Lys Met Glu Lys 
465                 470                 475                 480 


Ile Glu Val Glu Lys Ile Leu Asn Glu Ser Ile Leu Ser Glu Lys Ile 
                485                 490                 495     


Leu Lys Arg Val Lys Gln Tyr Thr Leu Glu His Ile Ile Tyr Leu Gly 
            500                 505                 510         


Lys Leu Arg His Asn Asp Ile Val Lys Met Thr Val Asn Thr Asn Asp 
        515                 520                 525             


Phe Ser Arg Leu His Ala Lys Glu Glu Leu Asp Leu Glu Leu Ile Thr 
    530                 535                 540                 


Phe Phe Ala Ser Thr Asn Met Glu Leu Asn Lys Ile Phe Asn Gly Lys 
545                 550                 555                 560 


Glu Lys Ile Thr Asp Phe Phe Gly Phe Asn Leu Asn Gly Gln Lys Ile 
                565                 570                 575     


Thr Leu Lys Glu Lys Val Pro Asn Phe Lys Leu Asn Ile Leu Lys Lys 
            580                 585                 590         


Leu Asn Phe Ile Asn Asn Glu Asn Asn Ile Asp Glu Lys Leu Ser His 
        595                 600                 605             


Phe Tyr Ser Phe Gln Lys Glu Gly Tyr Leu Leu Arg Asn Arg Ile Leu 
    610                 615                 620                 


His Asn Ser Tyr Gly Asn Thr Gln Glu Thr Lys Asn Leu Glu Gly Glu 
625                 630                 635                 640 


Tyr Glu Asn Val Glu Asn Leu Ile Lys Glu Leu Lys Val Asn Asp Glu 
                645                 650                 655     


Glu Ile Ser Lys Ser Leu Asn Leu Asp Ile Ile Phe Glu Gly Lys Val 
            660                 665                 670         


Asp Ile Ile Asn Lys Ile Asn Asn Leu Lys Ile Gly Glu Tyr Lys Asp 
        675                 680                 685             


Lys Lys Tyr Leu Pro Ser Phe Ser Lys Ile Val Pro Glu Ile Thr Arg 
    690                 695                 700                 


Lys Phe Arg Glu Ile Asn Lys Asp Lys Ser Phe Asp Ile Glu Ser Glu 
705                 710                 715                 720 


Lys Ile Ile Leu Asn Ala Val Gln Tyr Val Asn Lys Ile Leu Tyr Lys 
                725                 730                 735     


Lys Ile Thr Ser Asn Glu Glu Asn Glu Phe Ile Lys Thr Leu Pro Asp 
            740                 745                 750         


Lys Leu Val Lys Lys Asn Asn Asn Lys Glu Asn Lys Asn Ser Leu Ser 
        755                 760                 765             


Ile Glu Glu Tyr Tyr Lys Asn Ala Gln Ile Ser Ser Ser Lys Gly Asp 
    770                 775                 780                 


Lys Lys Ala Ile Lys Lys Tyr Gln Asn Lys Val Thr Asn Ala Tyr Ile 
785                 790                 795                 800 


Glu Tyr Leu Glu Asn Thr Phe Ala Lys Val Ile Asp Phe Ser Asn Phe 
                805                 810                 815     


Asn Leu Asn Phe Asp Glu Ile Lys Thr Lys Ile Glu Glu Arg Lys Tyr 
            820                 825                 830         


Ser Lys Ser Lys Ile Thr Val Asp Ser Ile Ser Thr Asn Ile Asn Ile 
        835                 840                 845             


Thr Asn Asp Ile Glu Tyr Ile Ile Ser Ile Phe Ala Leu Leu Asn Ser 
    850                 855                 860                 


Asn Thr Tyr Ile Asn Lys Ile Arg Asn Arg Phe Phe Ala Thr Ser Val 
865                 870                 875                 880 


Trp Leu Asn Thr Gln Lys Tyr Glu Asn Ile Ile Asp Ile Leu Asp Lys 
                885                 890                 895     


Ile Leu Ser Ile Asn Leu Leu Arg Glu Asn Asn Ile Ala Asp Ile Leu 
            900                 905                 910         


Asp Leu Lys Asn Thr Ile Ile Glu Ala Lys Ile Val Glu Asn Asn Glu 
        915                 920                 925             


Glu Cys Ile Lys Asn Tyr Ile Phe Glu Asn Asn Glu Glu Glu Leu Lys 
    930                 935                 940                 


Lys Arg Leu Phe Cys Glu Glu Leu Ile Asn Lys Glu Asp Val Leu Lys 
945                 950                 955                 960 


Ile Phe Glu Asp Lys Asn Phe Lys Phe Lys Asn Phe Ile Lys Lys Thr 
                965                 970                 975     


Gly Asn Glu Asn Phe Thr Ile Asp Phe Asp Ile Leu Phe Asn Leu Glu 
            980                 985                 990         


Cys Asn Ser Glu Leu Asn Ala Lys  Lys Val Ile Gly Gln  Asn Ser Gln 
        995                 1000                 1005             


Arg Leu  Asn Leu Phe Ile Lys  Asn Thr Ile Asp Glu  Tyr Lys Ser 
    1010                 1015                 1020             


Lys Ile  Lys Thr Ser Phe Ser  Ser Glu Phe Leu Glu  Lys Tyr Lys 
    1025                 1030                 1035             


Lys Glu  Ile Asp Asn Leu Val  Glu Asp Thr Glu Ser  Glu Asn Lys 
    1040                 1045                 1050             


Asn Lys  Phe Glu Lys Ile Tyr  Tyr Pro Glu Glu His  Lys Asn Glu 
    1055                 1060                 1065             


Leu Tyr  Ile Tyr Lys Lys Asn  Leu Phe Leu Asn Ile  Gly Asn Pro 
    1070                 1075                 1080             


Asn Phe  Asp Lys Ile Tyr Glu  Leu Ile Ser Lys Asp  Ile Lys Asn 
    1085                 1090                 1095             


Ala Asn  Thr Glu Ile Leu Phe  Asn Asp Asp Ile Arg  Lys Asn Lys 
    1100                 1105                 1110             


Ile Ala  Glu Ile Asp Val Ile  Leu Lys Asn Leu Asn  Asp Lys Leu 
    1115                 1120                 1125             


Asn Gly  Tyr Ser Lys Glu Tyr  Lys Glu Lys Tyr Ile  Lys Lys Leu 
    1130                 1135                 1140             


Lys Glu  Asn Gln Glu Asn Asn  Asp Phe Phe Ala Lys  Asn Ile Gln 
    1145                 1150                 1155             


Asn Glu  Asn Tyr Ser Ser Phe  Arg Glu Phe Lys Glu  Asp Tyr Asn 
    1160                 1165                 1170             


Lys Val  Ser Glu Tyr Lys Lys  Ile Arg Asp Leu Val  Glu Phe Asn 
    1175                 1180                 1185             


Tyr Leu  Asn Lys Ile Glu Ser  Tyr Leu Ile Asp Ile  Asn Trp Lys 
    1190                 1195                 1200             


Leu Ala  Ile Gln Met Ala Arg  Phe Glu Arg Asp Met  His Tyr Ile 
    1205                 1210                 1215             


Val Asn  Gly Leu Arg Glu Leu  Gly Ile Ile Lys Leu  Asn Gly Tyr 
    1220                 1225                 1230             


Asn Thr  Gly Ile Ser Arg Ala  Tyr Pro Lys Arg Asp  Gly Ser Asp 
    1235                 1240                 1245             


Asp Phe  Tyr Ala Thr Thr Ala  Tyr Tyr Lys Phe Phe  Asp Glu Glu 
    1250                 1255                 1260             


Ser Tyr  Lys Lys Phe Glu Lys  Ile Cys Tyr Lys Phe  Gly Ile Asp 
    1265                 1270                 1275             


Leu Ser  Glu Asn Ser Glu Ile  Asn Lys Pro Glu Asn  Glu Ser Ile 
    1280                 1285                 1290             


Arg Asn  Tyr Ile Ser His Phe  Tyr Ile Val Arg Asn  Pro Phe Ala 
    1295                 1300                 1305             


Asp Tyr  Ser Ile Ala Glu Gln  Ile Asp Arg Val Ser  Asn Leu Leu 
    1310                 1315                 1320             


Ser Tyr  Ser Thr Arg Tyr Asn  Asn Ser Thr Tyr Ala  Ser Val Phe 
    1325                 1330                 1335             


Glu Val  Phe Lys Lys Asp Val  Asp Leu Asp Tyr Asp  Glu Leu Lys 
    1340                 1345                 1350             


Lys Lys  Phe Lys Leu Ile Gly  Asn Asn Asp Ile Leu  Glu Arg Leu 
    1355                 1360                 1365             


Met Lys  Pro Lys Lys Val Ser  Val Leu Glu Leu Glu  Ser Tyr Asn 
    1370                 1375                 1380             


Ser Asn  Tyr Val Lys Asn Leu  Ile Ile Lys Leu Leu  Thr Lys Lys 
    1385                 1390                 1395             


Glu Asn  Thr Asn Asp Thr Leu  
    1400                 1405 


<210>  18
<211>  1194
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  18

Met Lys Val Thr Lys Ile Asp Gly Leu Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ile Glu Asp Ala Ser Gln Lys Asn Glu Thr 
            20                  25                  30          


Leu Glu Arg Leu Glu Asn Leu Lys Gly Ile Lys Leu Gly Asn Tyr Ile 
        35                  40                  45              


Lys Asn Thr Asp Lys Thr Lys Asn Lys Asp Asn Lys Lys Arg Arg Lys 
    50                  55                  60                  


Gly Leu Lys Glu Tyr Phe Ser Glu Ile Thr Leu Arg Lys Glu Asn Glu 
65                  70                  75                  80  


Lys Tyr Val Leu Leu Lys Gly Lys Lys Leu Lys Lys Ile Asn Asn Asp 
                85                  90                  95      


Ile Lys Asp Thr Asp Ile Lys Ala Lys Asp Lys Lys Glu Glu Val Phe 
            100                 105                 110         


Asp Ile Leu Lys Glu Ile Leu Lys Leu Asn Leu Leu Ala Asn Asp Ala 
        115                 120                 125             


Glu Glu Lys Ile Gln Phe Asp Ser Ile Lys Leu Lys Asn Val Phe Gly 
    130                 135                 140                 


Lys Asp Phe Val Lys Lys Glu Leu Gln Ile Lys Ser Ile Glu Glu Ser 
145                 150                 155                 160 


Leu Glu Lys Asn Lys Ala Asp Tyr Arg Lys Glu Phe Ile Glu Thr Glu 
                165                 170                 175     


Asn His Lys Tyr Gly Asn Val Lys Gly Lys Asn Lys Arg Ser His Ile 
            180                 185                 190         


Tyr Glu Tyr Tyr Lys Lys Ser Glu Asn His Lys Lys Phe Glu Asp Asn 
        195                 200                 205             


Ile Arg Glu Ala Phe Glu Lys Leu Tyr Thr Glu Glu Asn Ile Lys Glu 
    210                 215                 220                 


Leu Tyr Ser Lys Ile Glu Gln Val Leu Lys Lys Thr His Leu Lys Ser 
225                 230                 235                 240 


Ile Val Trp Glu Phe Tyr Lys Asn Glu Ile Ile Gly Glu Ser Glu Phe 
                245                 250                 255     


Ser Lys Lys Asn Gly Asp Gly Ile Ser Ile Leu Tyr Asn Gln Ile Lys 
            260                 265                 270         


Asp Ser Ile Lys Lys Glu Glu Asn Phe Ile Glu Phe Ile Glu Asn Ile 
        275                 280                 285             


Gly Asn Leu Glu Leu Lys Asp Leu Thr Lys Ser Gln Ile Phe Tyr Lys 
    290                 295                 300                 


Tyr Phe Leu Glu Asn Glu Glu Leu Asn Asp Glu Asn Ile Lys Phe Val 
305                 310                 315                 320 


Phe Cys Tyr Phe Val Glu Ile Glu Val Ser Asp Leu Leu Lys Gly Asn 
                325                 330                 335     


Val Tyr Lys Ala Ser Lys Ile Tyr Glu Asn Lys Ile Lys Asn Ile Phe 
            340                 345                 350         


Glu Tyr Gly Lys Leu Lys Lys Leu Ile Val Tyr Lys Leu Glu Asn Lys 
        355                 360                 365             


Leu Asn Asn Tyr Val Arg Asn Cys Gly Lys Tyr Asn Tyr His Met Glu 
    370                 375                 380                 


Asn Gly Asp Ile Ala Thr Ser Asp Ile Asn Met Arg Asn Arg Gln Thr 
385                 390                 395                 400 


Glu Ala Phe Leu Arg Ser Met Ile Gly Val Ser Ser Phe Gly Tyr Phe 
                405                 410                 415     


Ser Leu Arg Asn Ile Leu Gly Val Asn Asp Asp Asp Phe Tyr Glu Ile 
            420                 425                 430         


Glu Glu Asp Leu Thr Glu Glu Glu Arg Lys Asn Glu Ser Asn Ala Leu 
        435                 440                 445             


Lys Lys Ala Lys Glu Asp Ile Thr Ser Lys Ser Ile Phe Glu Lys Val 
    450                 455                 460                 


Val Asp Lys Ser Phe Glu Lys Lys Gly Ile Tyr Ser Ile Lys Glu Asn 
465                 470                 475                 480 


Leu Lys Met Phe Tyr Gly Asp Ser Phe Asp Lys Ala Asn Glu Asp Glu 
                485                 490                 495     


Leu Lys Gln Phe Phe Val Asn Met Leu Asn Ala Ile Thr Ser Ile Arg 
            500                 505                 510         


His Arg Val Val His Tyr Asn Met Asn Thr Asn Ser Glu Asn Ile Phe 
        515                 520                 525             


Asn Phe Ser Asp Ile Glu Val Ser Arg Leu Leu Lys Asn Ile Phe Glu 
    530                 535                 540                 


Lys Glu Thr Asp Lys Arg Glu Leu Lys Leu Lys Ile Phe Arg Gln Leu 
545                 550                 555                 560 


Asn Ser Ala Gly Val Phe Asp Tyr Trp Glu Ser Trp Lys Ile Lys Lys 
                565                 570                 575     


Tyr Leu Glu Asn Ile Glu Phe Lys Phe Val Asn Lys Asn Ile Pro Phe 
            580                 585                 590         


Val Pro Ser Phe Thr Lys Leu Tyr Asn Arg Ile Asp Asn Leu Lys Gly 
        595                 600                 605             


Asn Asn Ala Leu Lys Leu Gly Asn Tyr Ile Thr Ile Pro Lys Arg Lys 
    610                 615                 620                 


Glu Ala Arg Asp Ser Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly 
625                 630                 635                 640 


Glu Phe Val Glu Lys Phe Val Asn Asn Asn Asp Asn Phe Glu Lys Ile 
                645                 650                 655     


Phe Arg Glu Ile Ile Glu Ile Asn Lys Asn Ala Gly Thr Asn Thr Lys 
            660                 665                 670         


Thr Lys Phe Tyr Lys Leu Glu Lys Phe Glu Thr Leu Lys Ala Asn Thr 
        675                 680                 685             


Pro Thr Glu Tyr Leu Glu Lys Leu Gln Ser Leu His Gln Ile Asn Tyr 
    690                 695                 700                 


Asp Arg Glu Lys Ile Glu Glu Ala Lys Asp Ile Tyr Val Asp Phe Val 
705                 710                 715                 720 


Gln Lys Ile Phe Leu Lys Gly Phe Ile Asn Tyr Leu Gln Lys Ser Asn 
                725                 730                 735     


Ser Leu Lys Pro Leu Asn Leu Leu Asn Leu Lys Lys Asp Glu Val Ile 
            740                 745                 750         


Asn Ser Glu Lys Ser Ser Tyr Asp Glu Lys Leu Lys Gln Trp Glu Asn 
        755                 760                 765             


Asn Gly Ser Lys Leu Ser Glu Met Pro Lys Glu Ile Tyr Lys Tyr Ile 
    770                 775                 780                 


Lys Glu Ile Asn Ile Asn Lys Ile Asn Tyr Ser Asn Arg Met Ser Ile 
785                 790                 795                 800 


Phe Tyr Leu Leu Leu Lys Leu Ile Asp His Arg Glu Leu Thr Asn Leu 
                805                 810                 815     


Arg Gly Asn Leu Glu Lys Tyr Glu Ser Met Asn Lys Asn Lys Ile Tyr 
            820                 825                 830         


Ser Glu Glu Leu Asn Ile Val Asn Leu Val Ser Leu Asp Asn Asn Lys 
        835                 840                 845             


Val Arg Thr Asn Phe Ser Val Glu Ala Glu Asp Ile Gly Lys Phe Leu 
    850                 855                 860                 


Lys Thr Glu Thr Ser Ile Lys Asn Asn Lys Gln Leu Asn Asn Phe Ser 
865                 870                 875                 880 


Glu Ile Phe Ala Asp Gly Glu Asn Val Ile Lys His Arg Ser Phe Tyr 
                885                 890                 895     


Asn Ile Lys Lys Tyr Gly Ile Leu Asp Leu Leu Glu Lys Ile Val Thr 
            900                 905                 910         


Lys Ala Asp Leu Lys Ile Thr Lys Glu Glu Ile Lys Lys Tyr Lys Asn 
        915                 920                 925             


Leu Gln Lys Glu Leu Glu Lys Asn Asp Phe Tyr Lys Ile Gln Glu Asn 
    930                 935                 940                 


Ile His Arg Lys Tyr Asn Gln Lys Pro Asn Leu Ile Ser Arg Thr Glu 
945                 950                 955                 960 


Asn Lys Lys Asp Phe Asn Asp Tyr Lys Lys Ala Ile Glu Asn Ile Gln 
                965                 970                 975     


Asn Tyr Thr Gln Leu Lys Asn Lys Ile Glu Phe Asn Asp Leu Asn Leu 
            980                 985                 990         


Leu Gln Ser Leu Leu Phe Arg Ile  Leu His Arg Leu Ala  Gly Tyr Thr 
        995                 1000                 1005             


Ser Leu  Trp Glu Arg Asp Leu  Gln Phe Lys Leu Lys  Gly Glu Phe 
    1010                 1015                 1020             


Pro Glu  Asp Lys Tyr Ile Asp  Glu Ile Phe Asn Ser  Asp Arg Asn 
    1025                 1030                 1035             


Asn Asn  Gln Lys Tyr Lys Ser  Gly Gly Ile Ala Tyr  Lys Tyr Val 
    1040                 1045                 1050             


Asp Phe  Leu Ile Glu Lys Glu  Glu Gly Lys Arg Ala  Gly Lys Asn 
    1055                 1060                 1065             


Lys Val  Lys Lys Arg Ser Glu  Lys Glu Gly Ser Phe  Ile Ile Arg 
    1070                 1075                 1080             


Asn Tyr  Ile Ala His Phe Asn  Tyr Ile Pro Asp Ala  Glu Lys Ser 
    1085                 1090                 1095             


Ile Leu  Glu Ile Leu Glu Glu  Leu Arg Glu Leu Leu  Lys Tyr Asp 
    1100                 1105                 1110             


Arg Lys  Leu Lys Asn Ala Val  Met Lys Ser Val Lys  Asp Ile Phe 
    1115                 1120                 1125             


Lys Glu  Tyr Gly Phe Ile Val  Glu Phe Gly Ile Ser  His Glu Ser 
    1130                 1135                 1140             


Asn Asn  Lys Lys Ile Thr Ile  Asn Lys Val Tyr Ser  Glu Lys Ile 
    1145                 1150                 1155             


Glu His  Leu Lys Lys Ala Lys  Leu Glu Lys Glu Asp  Lys Leu Glu 
    1160                 1165                 1170             


Thr Thr  Arg Asn Ser Glu Asp  Leu Cys Lys Leu Val  Lys Val Met 
    1175                 1180                 1185             


Leu Glu  Tyr Lys Lys Ser 
    1190                 


<210>  19
<211>  1242
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  19

Met Lys Ile Thr Lys Ile Asp Gly Val Ser His Tyr Lys Glu Lys Glu 
1               5                   10                  15      


Lys Gly Val Leu Lys Gly Lys Asp Ile Leu Asn Gly Lys Ile Glu Lys 
            20                  25                  30          


Ile Val Lys Lys Arg Tyr Asp Ala Thr Ile Glu Ser Lys Ile Tyr Lys 
        35                  40                  45              


Glu Phe Ile Lys Leu Arg Lys Asn Arg Ile Glu Gln Asn Asn Glu Lys 
    50                  55                  60                  


Ser Ile Leu Lys Leu Ile Lys Leu Asn Ile Asp Lys Asn Glu Lys Glu 
65                  70                  75                  80  


Ile Lys Thr Leu Leu Leu Asn Lys Phe Lys Ile Lys Glu Lys Asn Lys 
                85                  90                  95      


Lys Tyr Asp Lys Tyr Met Leu Asp Glu Asn Lys Leu Asp Asn Asp Ile 
            100                 105                 110         


Lys Ile Tyr Glu Ser Val Glu Ser Leu Tyr Phe Leu Ile Lys Glu Ile 
        115                 120                 125             


Tyr Leu Gly Gln Asn Asn Lys Lys Trp Asn Ile Ser Lys Ile Asp Leu 
    130                 135                 140                 


Glu Lys Ile Met Glu Glu Asp Asn Asn Leu Ile Met Leu Gly Tyr Lys 
145                 150                 155                 160 


Leu Lys Lys Asn Ile Thr Glu Asn Asp Tyr Pro Tyr Leu Tyr Ser Asp 
                165                 170                 175     


Lys Asn Gly Gln Glu Ser Thr Ser Val Tyr Lys Leu Leu Lys Lys Leu 
            180                 185                 190         


Ile Glu Glu Asn Lys Asp Arg Asn Gln Asp Ile Arg Lys Ser Gln Glu 
        195                 200                 205             


Tyr Glu Lys Ile Arg Lys Asn Phe Glu Glu Tyr Lys Asn Arg Lys Ile 
    210                 215                 220                 


Asn Leu Leu Val Lys Ser Ile Lys Asn Asn Lys Ile Asn Ile Gln Tyr 
225                 230                 235                 240 


Ile Asn Asn Glu Ile Lys Ser His Asn Asn Ser Arg Glu Glu Asn Ile 
                245                 250                 255     


Ile Lys Phe Phe Lys Lys Met Ile Glu Glu Lys Asn Lys Pro Ile Leu 
            260                 265                 270         


Lys Asp Lys Leu Lys Leu Phe Arg Leu Lys Val Phe Phe Asp Glu Glu 
        275                 280                 285             


Phe Leu Glu Glu Ile Lys Lys Leu Leu Asp Ser Asp Asp Leu Asp Lys 
    290                 295                 300                 


Ser Asp Asn Lys Lys Ile Ser Glu Leu Arg Gly Lys Ile Phe Ser Arg 
305                 310                 315                 320 


Ile Arg Glu Lys Ile Lys Glu Asn Arg Asp Arg Asp Ile Leu Glu Asn 
                325                 330                 335     


Ile Tyr Phe Leu Glu Leu Lys Lys Tyr Ile Glu Asn Asn Leu Ser His 
            340                 345                 350         


Lys Lys Glu Asn Asn Lys Lys Asn Asn Asn Ile Gly Glu Glu Lys Ser 
        355                 360                 365             


Lys Lys Leu Tyr Leu Lys Phe Leu Lys Lys Val Leu Phe Ile Asp Asp 
    370                 375                 380                 


Asn Asn Arg Ile Asn Ile Glu Lys Leu Lys Ser Arg Ile Asp Asp Asn 
385                 390                 395                 400 


Phe Lys Asn Leu Leu Ile Gln His Val Ile Glu Tyr Gly Lys Ile Lys 
                405                 410                 415     


Tyr Tyr Val Glu Asn Asp Asp Tyr Ile Lys Asn Ile Val Lys Asn Gly 
            420                 425                 430         


Glu Leu Lys Leu Glu Thr Glu Asn Leu Glu Tyr Ile Arg Ile Arg Glu 
        435                 440                 445             


Thr Leu Ile Arg Lys Met Ala Val Leu Val Ser Phe Ala Ala Asn Ser 
    450                 455                 460                 


Tyr Tyr Asn Leu Phe Gly Arg Thr Glu Asn Asn Ile Leu Thr Gln Glu 
465                 470                 475                 480 


Ile Ser Asp Asp Leu Leu Leu Gly Lys Ile Glu Asn Glu Ile Tyr Ile 
                485                 490                 495     


Lys Gly Glu Lys Asn Arg Arg Tyr Val Phe Lys Glu Lys Met Leu Asn 
            500                 505                 510         


Tyr Phe Phe Asn Pro Glu Ile Phe Gly Asp Asn Lys Ile Val Glu Val 
        515                 520                 525             


Leu Ser Ala Ile Ser Ser Ser Ile Tyr Asn Ile Arg Asn Gly Val Asn 
    530                 535                 540                 


His Phe Asp Lys Ile Asn Leu Gly Gln Tyr Asn Asn Leu Asp Leu Ser 
545                 550                 555                 560 


Glu Ile Lys Lys Tyr Phe Ile Glu Lys Arg Asp Lys Ile Lys Glu Lys 
                565                 570                 575     


Val Lys Glu Lys Phe Ser Ser Asn Asn Leu Gln Tyr Tyr Tyr Ala Lys 
            580                 585                 590         


Lys Glu Ile Glu Asn Tyr Phe Lys Ala Tyr Glu Phe Glu Ile Leu Lys 
        595                 600                 605             


Glu Lys Ile Pro Phe Ala Pro Asn Phe Lys Arg Ile Ile Lys Lys Gly 
    610                 615                 620                 


Glu Asp Leu Phe Asn Asn Lys Lys Asn Lys Lys Tyr Glu Tyr Phe Lys 
625                 630                 635                 640 


Asn Phe Asp Lys Asn Ile Ala Glu Glu Lys Lys Glu Phe Leu Lys Thr 
                645                 650                 655     


Arg Asn Phe Leu Leu Lys Glu Leu Tyr Tyr Asn Asn Phe Tyr Lys Glu 
            660                 665                 670         


Phe Leu Ser Lys Lys Glu Glu Phe Lys Lys Val Val Ile Glu Val Lys 
        675                 680                 685             


Glu Glu Lys Lys Asn Arg Gly Asn Ile Asn Asn Lys Lys Ser Gly Val 
    690                 695                 700                 


Ser Phe Gln Ser Ile Asp Asp Tyr Asp Thr Lys Ile Asn Ile Ser Asp 
705                 710                 715                 720 


Tyr Ile Ala Ser Ile His Lys Lys Glu Met Glu Arg Val Glu Lys Tyr 
                725                 730                 735     


Asn Glu Glu Lys Gln Lys Asp Thr Ala Lys Tyr Ile Arg Asp Phe Val 
            740                 745                 750         


Glu Glu Ile Phe Leu Thr Gly Phe Ile Asn Tyr Leu Glu Lys Asp Lys 
        755                 760                 765             


Arg Leu His Phe Leu Lys Glu Glu Phe Ser Ile Leu Cys Asn Asn Asn 
    770                 775                 780                 


Asn Asn Val Val Asp Phe Asn Ile Asn Ile Asn Glu Glu Lys Ile Lys 
785                 790                 795                 800 


Glu Phe Leu Lys Glu Asn Asp Ser Lys Thr Leu Asn Leu Tyr Leu Phe 
                805                 810                 815     


Phe Asn Met Ile Asp Ser Lys Arg Ile Ser Glu Phe Arg Asn Glu Leu 
            820                 825                 830         


Ile Lys Tyr Lys Gln Phe Thr Lys Arg Arg Leu Asp Glu Lys Lys Glu 
        835                 840                 845             


Phe Leu Gly Ile Glu Ile Glu Leu Tyr Glu Thr Leu Ile Glu Phe Val 
    850                 855                 860                 


Ile Leu Thr Arg Glu Lys Leu Asp Thr Lys Lys Ser Glu Glu Ile Asp 
865                 870                 875                 880 


Ala Trp Leu Val Asp Lys Leu Tyr Val Lys Asp Asn Asn Glu Tyr Lys 
                885                 890                 895     


Glu Tyr Glu Glu Ile Leu Lys Leu Phe Val Asp Glu Lys Ile Leu Ser 
            900                 905                 910         


Ser Lys Glu Ala Pro Tyr Tyr Ala Thr Asp Asn Lys Thr Pro Ile Leu 
        915                 920                 925             


Leu Ser Asn Phe Glu Lys Thr Arg Lys Tyr Gly Thr Gln Ser Phe Leu 
    930                 935                 940                 


Ser Glu Ile Gln Ser Asn Tyr Lys Tyr Asn Lys Val Glu Lys Glu Asn 
945                 950                 955                 960 


Ile Glu Asp Tyr Asn Lys Lys Glu Glu Ile Glu Gln Lys Lys Lys Ser 
                965                 970                 975     


Asn Ile Glu Lys Leu Gln Asp Leu Lys Val Glu Leu His Lys Lys Trp 
            980                 985                 990         


Glu Gln Asn Lys Ile Thr Glu Arg  Glu Ile Lys Lys Tyr  Asn Asp Thr 
        995                 1000                 1005             


Ile Lys  Glu Ile Arg Glu Tyr  Asn Tyr Leu Lys Asn  Lys Glu Glu 
    1010                 1015                 1020             


Leu Gln  Asn Val Tyr Leu Leu  His Glu Ile Leu Ser  Asp Leu Leu 
    1025                 1030                 1035             


Ala Arg  Asn Val Ala Phe Phe  Asn Lys Trp Glu Arg  Asp Phe Lys 
    1040                 1045                 1050             


Phe Ile  Val Ile Ala Ile Lys  Gln Phe Leu Arg Glu  Asn Asp Lys 
    1055                 1060                 1065             


Glu Lys  Val Asn Glu Phe Leu  Asn Pro His Lys Ser  Asp Gly Ser 
    1070                 1075                 1080             


Arg Asp  Asn Phe Ser Val Thr  Asn Tyr Arg Ser Lys  Met Lys Ser 
    1085                 1090                 1095             


Ile Ile  Asn Asn Ile His Glu  Asn Phe Met Ser Leu  Leu Phe Leu 
    1100                 1105                 1110             


Asn Asn  Asn Leu Ala Thr Gly  Gly Ile Gln Met Gly  Arg Asn Asn 
    1115                 1120                 1125             


Asn Phe  Thr Trp Gly Asn Leu  Arg Asn Tyr Ile Ala  His Phe Glu 
    1130                 1135                 1140             


Tyr Leu  His Lys Glu Lys Asp  Thr Ile Ser Phe Leu  Asn Gln Ala 
    1145                 1150                 1155             


Asn Leu  Leu Ile Lys Leu Phe  Ser Tyr Asp Lys Lys  Val Gln Asn 
    1160                 1165                 1170             


His Ile  Ile Lys Ser Met Lys  Thr Leu Leu Glu Lys  Tyr Asn Ile 
    1175                 1180                 1185             


Glu Ile  Gly Phe Glu Ile Ser  Asn Asp Ser Glu Glu  Ile Phe Glu 
    1190                 1195                 1200             


Tyr Lys  Ile Lys Tyr Ile Asn  Ser Lys Lys Gly Lys  Met Leu Gly 
    1205                 1210                 1215             


Lys Asn  Asn Glu Phe Lys Ile  Leu Glu Asn Glu Phe  Val Arg Asn 
    1220                 1225                 1230             


Val Lys  Ala Leu Leu Glu Tyr  Ser Lys 
    1235                 1240         


<210>  20
<211>  1169
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  20

Met Lys Ile Thr Lys Ile Asp Gly Ile Ser His Lys Lys Tyr Ile Lys 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Lys Thr Asp Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Thr Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Glu Phe Phe Ser Asn Lys Val Leu His Leu Glu Asp Gly Ile Leu 
65                  70                  75                  80  


Tyr Leu Lys Asp Arg Arg Glu Lys Asn Ala Val Gln Asn Lys Asn Tyr 
                85                  90                  95      


Ser Glu Gln Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Met Phe Arg Lys Asp Ile Asp Lys Lys Leu Asp Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Leu Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Ile Lys Lys Val Glu Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Phe Tyr Asn Tyr Tyr Lys Asp Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Ile Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Asn Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Thr Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Met 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asn Val Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Ser Lys Glu Lys Leu Asn Asp Glu 
        275                 280                 285             


Asn Ile Lys Tyr Val Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Ser Phe Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asn Phe Ile 
        355                 360                 365             


Val Gly Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Lys Asp Asp Ile Thr Gly Lys Met Arg Gly Lys Thr Arg Ile Asp Ser 
                405                 410                 415     


Lys Thr Arg Glu Glu Lys Tyr Ile Pro Gly Glu Val Asp Gln Ile Tyr 
            420                 425                 430         


Tyr Glu Asn Lys Gln Asn Glu Val Lys Asn Lys Leu Lys Met Phe Tyr 
        435                 440                 445             


Gly Tyr Asp Phe Asp Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe 
    450                 455                 460                 


Ala Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His 
465                 470                 475                 480 


Phe Asn Leu Asp Leu Asp Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile 
                485                 490                 495     


Val Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu 
            500                 505                 510         


Lys Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val 
        515                 520                 525             


Phe Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr 
    530                 535                 540                 


Arg Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr 
545                 550                 555                 560 


Lys Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr 
                565                 570                 575     


Trp Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile 
            580                 585                 590         


Asp Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu 
        595                 600                 605             


Asn Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Lys Glu 
    610                 615                 620                 


Ile Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe 
625                 630                 635                 640 


Tyr Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Ile Pro Lys Glu 
                645                 650                 655     


Tyr Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln 
            660                 665                 670         


Asp Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe 
        675                 680                 685             


Leu Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu 
    690                 695                 700                 


Ile Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys 
705                 710                 715                 720 


Lys Gln Glu Phe Asp Lys Phe Ser Lys Lys Tyr Glu Gln Asn Asn Asn 
                725                 730                 735     


Ile Lys Ile Pro Tyr Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu 
            740                 745                 750         


Gly Lys Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile 
        755                 760                 765             


Leu Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu 
    770                 775                 780                 


Glu Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Gln Leu 
785                 790                 795                 800 


Glu Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp 
                805                 810                 815     


Phe Glu Leu Glu Ala Asp Glu Ile Gly Lys Phe Leu Asn Phe Asn Gly 
            820                 825                 830         


Asn Lys Val Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Lys Lys 
        835                 840                 845             


Ile Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn 
    850                 855                 860                 


Ile Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu 
865                 870                 875                 880 


Ala Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Lys Tyr Ser Asn Lys 
                885                 890                 895     


Lys Asn Lys Ile Glu Lys Asn His Lys Met Gln Glu Asn Leu Tyr Arg 
            900                 905                 910         


Lys Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr 
        915                 920                 925             


Glu Ser Tyr Lys Gln Ala Ile Lys Asn Ile Glu Glu Tyr Thr His Leu 
    930                 935                 940                 


Lys Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Ser Leu Leu 
945                 950                 955                 960 


Leu Arg Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg 
                965                 970                 975     


Asp Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile 
            980                 985                 990         


Glu Glu Ile Phe Asn Phe Glu Asn  Lys Lys Asn Val Lys  Tyr Lys Ser 
        995                 1000                 1005             


Gly Gln  Ile Val Glu Lys Tyr  Ile Lys Phe Tyr Lys  Glu Leu His 
    1010                 1015                 1020             


Gln Asn  Asp Glu Val Lys Ile  Asn Lys Tyr Ser Ser  Ala Asn Ile 
    1025                 1030                 1035             


Lys Val  Leu Lys Gln Glu Lys  Lys Asp Leu Tyr Ile  Arg Asn Tyr 
    1040                 1045                 1050             


Ile Ala  His Phe Asn Tyr Ile  Pro His Ala Glu Ile  Ser Leu Leu 
    1055                 1060                 1065             


Glu Val  Leu Glu Asn Leu Arg  Lys Leu Leu Ser Tyr  Asp Arg Lys 
    1070                 1075                 1080             


Leu Lys  Asn Ala Val Met Lys  Ser Val Val Asp Ile  Leu Lys Glu 
    1085                 1090                 1095             


Tyr Gly  Phe Val Val Lys Phe  Lys Ile Gly Ala Asp  Lys Lys Ile 
    1100                 1105                 1110             


Glu Ile  Gln Ser Leu Lys Ser  Glu Glu Ile Val His  Leu Lys Lys 
    1115                 1120                 1125             


Leu Lys  Leu Lys Asp Asn Asp  Lys Lys Lys Glu Pro  Ile Lys Thr 
    1130                 1135                 1140             


Tyr Arg  Asn Ser Lys Glu Leu  Cys Lys Leu Val Lys  Val Met Phe 
    1145                 1150                 1155             


Glu Tyr  Lys Met Glu Glu Lys  Lys Ser Glu Asn 
    1160                 1165                 


<210>  21
<211>  1186
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  21

Met Lys Val Thr Lys Ile Asp Gly Leu Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ile Glu Asp Ala Ser Gln Lys Asn Glu Thr 
            20                  25                  30          


Leu Glu Arg Leu Glu Lys Leu Lys Glu Ile Lys Leu Gly Asn Tyr Ile 
        35                  40                  45              


Lys Asn Pro Asp Lys Thr Lys Asp Lys Asp Asn Lys Lys Arg Arg Lys 
    50                  55                  60                  


Gly Leu Lys Glu Tyr Phe Ser Glu Ile Thr Leu Arg Lys Glu Asn Glu 
65                  70                  75                  80  


Lys Tyr Val Leu Leu Lys Gly Lys Lys Leu Lys Lys Ile Asn Asn Asp 
                85                  90                  95      


Ile Lys Asp Thr Asp Ile Lys Val Lys Tyr Lys Lys Glu Glu Val Phe 
            100                 105                 110         


Asp Val Leu Lys Lys Ile Leu Lys Leu Asn Leu Leu Ala Asn Asp Val 
        115                 120                 125             


Glu Glu Lys Ile Gln Phe Asp Ser Ile Lys Leu Lys Asn Val Phe Gly 
    130                 135                 140                 


Lys Asp Phe Val Lys Lys Glu Leu Gln Ile Lys Ser Ile Glu Glu Ser 
145                 150                 155                 160 


Leu Glu Lys Asn Lys Ala Asp Tyr Arg Lys Glu Phe Ile Glu Ile Glu 
                165                 170                 175     


Asn Asp Lys Tyr Gly Asn Val Lys Gly Glu Asn Lys Lys Asn Arg Ile 
            180                 185                 190         


Tyr Glu Tyr Tyr Lys Lys Ser Glu Thr His Glu Lys Phe Arg Lys Asn 
        195                 200                 205             


Ile Ile Glu Ala Phe Glu Lys Leu Tyr Lys Lys Asp Asp Ile Glu Lys 
    210                 215                 220                 


Leu Tyr Thr Gln Ile Ile Glu Ile Ser Lys Lys Met His Leu Lys Ser 
225                 230                 235                 240 


Lys Val Arg Glu Leu Tyr Lys Asn Val Ile Ile Lys Arg Ser Cys Asp 
                245                 250                 255     


Asp Phe Ser Lys Lys Asn Lys Glu Gly Ile Ser Val Leu Tyr Ser Gln 
            260                 265                 270         


Ile Met Asn Ser Val Lys Lys Asn Glu Lys Phe Val Lys Phe Val Lys 
        275                 280                 285             


Asn Ile Glu Leu Lys Asp Leu Thr Lys Ser Gln Ile Phe Tyr Lys Tyr 
    290                 295                 300                 


Phe Leu Glu Asn Glu Glu Leu Asn Asp Glu Asn Ile Lys Asn Ile Phe 
305                 310                 315                 320 


Cys Tyr Phe Val Glu Ile Glu Val Ser Asp Leu Leu Lys Gly Asn Val 
                325                 330                 335     


Tyr Lys Val Ser Lys Ile Tyr Glu Asn Lys Ile Lys Asn Ile Phe Glu 
            340                 345                 350         


Tyr Asn Lys Leu Lys Lys Leu Val Ile Asn Lys Leu Glu Asn Lys Leu 
        355                 360                 365             


Asn Asn Tyr Val Arg Asn Cys Gly Lys Tyr Asn Tyr His Met Glu Asn 
    370                 375                 380                 


Gly Asp Ile Ala Thr Ser Asp Ile Asn Met Arg Asn Arg Gln Thr Glu 
385                 390                 395                 400 


Ala Phe Leu Arg Ser Met Ile Gly Val Ser Ser Phe Gly Tyr Phe Ser 
                405                 410                 415     


Leu Arg Asn Ile Leu Gly Val Asn Asp Asp Asp Phe Tyr Glu Ile Glu 
            420                 425                 430         


Glu Asp Leu Thr Glu Glu Glu Arg Lys Asn Glu Ser Asn Val Leu Lys 
        435                 440                 445             


Lys Ala Lys Glu Asp Ile Thr Ser Lys Ser Ile Phe Glu Lys Val Val 
    450                 455                 460                 


Asp Lys Ser Phe Glu Lys Lys Gly Ile His Ser Ile Arg Glu Asn Val 
465                 470                 475                 480 


Lys Met Phe Tyr Gly Asp Ser Phe Asp Lys Ala Asn Glu Asp Glu Leu 
                485                 490                 495     


Lys Gln Phe Phe Val Asn Met Leu Asn Ala Ile Thr Ser Ile Arg His 
            500                 505                 510         


Arg Val Val His Tyr Asn Met Asn Thr Asn Ser Glu Asn Ile Phe Asn 
        515                 520                 525             


Phe Ser Asp Ile Glu Val Ser Arg Leu Leu Lys Ser Ile Phe Glu Lys 
    530                 535                 540                 


Glu Thr Asp Lys Arg Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn 
545                 550                 555                 560 


Ser Ala Gly Val Phe Asp Tyr Trp Glu Asn Trp Lys Ile Lys Lys Tyr 
                565                 570                 575     


Leu Glu Asn Met Lys Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val 
            580                 585                 590         


Pro Ser Phe Thr Lys Leu Tyr Asn Arg Ile Asp Asn Leu Lys Gly Ser 
        595                 600                 605             


Asn Ala Leu Asn Leu Gly Tyr Ile Asn Ile Pro Lys Arg Lys Glu Ala 
    610                 615                 620                 


Arg Asp Ser Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Lys Phe 
625                 630                 635                 640 


Val Glu Glu Phe Ile Lys Asn Asn Asp Asn Phe Glu Lys Ile Phe Arg 
                645                 650                 655     


Glu Ile Ile Glu Ile Asn Lys Asn Ala Gly Thr Asn Lys Gln Thr Asn 
            660                 665                 670         


Phe Tyr Lys Leu Glu Lys Phe Glu Lys Leu Lys Ala Asn Thr Pro Thr 
        675                 680                 685             


Glu Tyr Leu Glu Lys Leu Gln Ser Leu His Lys Ile Asn Tyr Asn Arg 
    690                 695                 700                 


Glu Lys Ile Glu Glu Asp Lys Asp Ile Tyr Val Asp Phe Val Gln Lys 
705                 710                 715                 720 


Ile Phe Leu Lys Gly Phe Ile Ser Tyr Leu Gln Lys Ser Asn Ser Leu 
                725                 730                 735     


Lys Pro Leu Asn Leu Leu Asn Leu Lys Lys Asp Glu Val Ile Asn Ser 
            740                 745                 750         


Glu Lys Ser Phe Tyr Asp Glu Lys Leu Lys Gln Trp Glu Asn Asn Gly 
        755                 760                 765             


Ser Asn Leu Ser Glu Met Pro Lys Glu Ile Tyr Lys Tyr Ile Lys Glu 
    770                 775                 780                 


Ile Lys Ile Asn Lys Thr Asn Tyr Ser Asp Arg Met Ser Ile Phe Tyr 
785                 790                 795                 800 


Leu Leu Leu Lys Leu Ile Asp His Lys Glu Leu Thr Asn Leu Arg Gly 
                805                 810                 815     


Asn Leu Glu Lys Tyr Glu Ser Met Asn Lys Asn Lys Ile Tyr Ser Glu 
            820                 825                 830         


Glu Leu Asn Ile Val Asn Leu Val Ser Leu Asp Asn Asn Lys Val Arg 
        835                 840                 845             


Thr Asn Phe Ser Val Glu Ala Glu Asp Ile Gly Lys Phe Leu Lys Thr 
    850                 855                 860                 


Glu Thr Ser Ile Lys Asn Ile Asn Gln Leu Asn Asn Phe Ser Gly Ile 
865                 870                 875                 880 


Phe Ala Asp Gly Glu Asn Val Ile Lys His Arg Ser Phe Tyr Asn Ile 
                885                 890                 895     


Lys Lys Tyr Gly Ile Leu Asp Leu Leu Glu Lys Ile Val Ala Lys Ala 
            900                 905                 910         


Asp Leu Lys Ile Ala Lys Glu Glu Ile Lys Lys Tyr Glu Asn Leu Gln 
        915                 920                 925             


Lys Glu Leu Glu Lys Asn Asp Phe Tyr Lys Ile Gln Glu Lys Ile His 
    930                 935                 940                 


Arg Lys Tyr Asn Gln Lys Pro Asn Leu Ile Ser Arg Thr Glu Asn Lys 
945                 950                 955                 960 


Lys Asp Phe Asn Asp Tyr Lys Lys Ala Ile Glu Asn Ile Gln Asn Tyr 
                965                 970                 975     


Thr Gln Leu Lys Asn Lys Ile Glu Phe Asn Asp Leu Asn Leu Leu Gln 
            980                 985                 990         


Gly Leu Leu Phe Arg Ile Leu His  Arg Leu Thr Gly Tyr  Thr Ser Leu 
        995                 1000                 1005             


Trp Glu  Arg Asp Leu Gln Phe  Lys Leu Lys Gly Glu  Phe Pro Glu 
    1010                 1015                 1020             


Asp Lys  Tyr Ile Asp Glu Ile  Phe Asn Ser Asp Arg  Asn Asn Asn 
    1025                 1030                 1035             


Gln Lys  Tyr Lys Ser Gly Gly  Ile Ala Tyr Lys Tyr  Val Asp Phe 
    1040                 1045                 1050             


Leu Ile  Glu Lys Glu Glu Gly  Lys Arg Ala Gly Lys  Asn Lys Val 
    1055                 1060                 1065             


Lys Lys  Arg Ser Glu Arg Glu  Arg Ser Phe Ile Ile  Arg Asn Tyr 
    1070                 1075                 1080             


Ile Ala  His Phe Asn Tyr Ile  Pro Asp Ala Glu Lys  Ser Ile Leu 
    1085                 1090                 1095             


Glu Ile  Leu Glu Glu Leu Arg  Glu Leu Leu Lys Tyr  Asp Arg Lys 
    1100                 1105                 1110             


Leu Lys  Asn Ala Val Met Lys  Ser Ile Lys Asp Ile  Phe Lys Glu 
    1115                 1120                 1125             


Tyr Gly  Phe Ile Ile Glu Phe  Gly Ile Ser His Glu  Ser Asn Ser 
    1130                 1135                 1140             


Lys Lys  Ile Lys Val Leu Asn  Val Glu Ser Glu Lys  Ile Lys His 
    1145                 1150                 1155             


Leu Lys  Asn Asn Gly Leu Val  Thr Thr Arg Asn Ser  Lys Asp Leu 
    1160                 1165                 1170             


Cys Lys  Leu Val Lys Val Met  Leu Glu Tyr Lys Lys  Ser 
    1175                 1180                 1185     


<210>  22
<211>  1415
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  22

Met Lys Met Gly Asn Leu Phe Gly Tyr Lys Lys Trp Tyr Lys Val Asp 
1               5                   10                  15      


Lys Ile Ile Lys Gly Lys Glu Val Lys Val Glu Val Arg Ile Lys Arg 
            20                  25                  30          


Lys Tyr Leu Asp Asn Glu Ser Lys Tyr Val Leu Asn Ile Asn Lys Gln 
        35                  40                  45              


Lys Glu Glu Tyr Asp Glu Asn Lys Ile Thr Asp Lys Glu Phe Ile Asp 
    50                  55                  60                  


Gln Phe Ile Glu Tyr Lys Thr Asn Asn Asp Ile Phe Glu Lys Phe Lys 
65                  70                  75                  80  


Arg Lys Phe His Met Gly Asn Ile Leu Phe Lys Leu Lys Ala Lys Glu 
                85                  90                  95      


Leu Thr Glu Lys Thr Ile Lys Glu Ile Arg Asn Tyr Asn Asp Phe Leu 
            100                 105                 110         


Glu Lys Glu Lys Ala Ile Leu Glu Ile Glu Ile Tyr Gln Gln Ser Glu 
        115                 120                 125             


Lys Leu Ile Glu Glu Glu Asn Ile Thr Lys Lys Asp Ile Ile Asp Lys 
    130                 135                 140                 


Ala Ile Lys Glu Lys Ile Thr Glu Asp Ser Asn Glu Ile Lys Met Gln 
145                 150                 155                 160 


Ile Lys Ser Lys Glu Asn Lys Ser Lys Glu Ile Lys Ile Ser Ile Asn 
                165                 170                 175     


Lys Glu Thr Glu Glu Tyr His Ile Lys Leu Lys Ser Ile Asn Asn Asp 
            180                 185                 190         


Glu Leu Asn Leu Lys Arg Glu Ile Tyr Glu Ile Leu Lys Ser Ile Asn 
        195                 200                 205             


Ala Asn Leu Tyr Thr Ile Thr Lys Asn Thr Ile Ser Asn Ala Asp Phe 
    210                 215                 220                 


Lys Lys Arg Asn Tyr Glu Asn Phe Leu Arg Glu Asn Ile Met Glu His 
225                 230                 235                 240 


Leu Lys Lys Asn Ile Arg Glu Lys Ser Lys Met Thr Phe Leu Lys Ser 
                245                 250                 255     


Leu Ser Asn Ser Leu Lys Lys Ile Gln Gly Asn Ile Lys Glu Asn Asp 
            260                 265                 270         


Glu Ile Ile Asn Phe Ile Lys Tyr Tyr Ser Asn Ile Asn Gly Ser Lys 
        275                 280                 285             


Thr Val Ser Glu Asn Lys Lys Asn Phe Leu Glu Lys Ile Leu Asn Thr 
    290                 295                 300                 


Glu Val Ser Val Ser Glu Asn Asp Ile Ile Asp Phe Ile Ile Gly Glu 
305                 310                 315                 320 


Leu Lys Phe Tyr Gly Ile Ile Lys Arg Ile Glu Lys Leu Gln Glu Lys 
                325                 330                 335     


Thr Ala Asp Arg Thr Asp Glu Asp Ile Glu Asn Thr Tyr Ile Glu Ser 
            340                 345                 350         


Tyr Val Leu Leu Asp Lys His Glu Lys Phe Lys Lys Tyr Asn Arg Asn 
        355                 360                 365             


Lys Lys Asp Glu Ile Val Lys Leu Phe Val Lys Asp Ile His Asn Asn 
    370                 375                 380                 


Thr Met Glu Glu Lys Ile Asn Gln Ile Leu Ser Lys Phe Lys Ile Lys 
385                 390                 395                 400 


Glu Leu Thr Glu Lys Leu Lys Glu Asn Pro Lys Asn Lys Asn Phe Asp 
                405                 410                 415     


Thr Glu Ile Phe Gly Ile Phe Lys Ile His Tyr Lys Lys Ile Phe Ser 
            420                 425                 430         


Ser Glu Lys Phe Glu Asn Lys Ser Asp Glu Glu Lys Glu Leu Tyr Lys 
        435                 440                 445             


Ile Ile Tyr Arg Tyr Leu Lys Gly Arg Ile Glu Lys Ile Leu Ile Asn 
    450                 455                 460                 


Glu Glu Lys Val Arg Leu Lys Lys Met Glu Lys Ile Leu Ile Asn Gly 
465                 470                 475                 480 


Glu Lys Ile Arg Leu Asn Lys Ile Glu Lys Ile Glu Ile Glu Lys Ile 
                485                 490                 495     


Leu Asn Glu Ser Val Leu Ser Glu Lys Ile Leu Lys Arg Val Lys Gln 
            500                 505                 510         


Tyr Thr Leu Glu His Ile Met Tyr Leu Gly Lys Leu Ile His Asn Asp 
        515                 520                 525             


Val Asn Met Ile Thr Val Asn Thr Asn Asp Phe Ser Arg Leu His Ala 
    530                 535                 540                 


Lys Glu Glu Leu Asp Leu Glu Leu Ile Thr Phe Phe Ala Ser Thr Asn 
545                 550                 555                 560 


Met Glu Leu Asn Lys Ile Phe Ser Lys Glu Lys Ile Asn Asp Asp Glu 
                565                 570                 575     


Asn Ile Asp Phe Phe Gly Phe Asn Leu Asn Gly Gln Lys Ile Thr Leu 
            580                 585                 590         


Lys Glu Lys Val Pro Ser Phe Lys Leu Asn Ile Leu Lys Lys Leu Asn 
        595                 600                 605             


Phe Ile Asn Asn Glu Asn Asn Ile Asp Glu Lys Leu Ser His Phe Tyr 
    610                 615                 620                 


Ser Phe Gln Lys Glu Gly Tyr Leu Leu Arg Asn Arg Ile Leu His Asn 
625                 630                 635                 640 


Tyr Tyr Gly Asn Ile Gln Glu Thr Lys Asn Leu Glu Gly Glu Tyr Glu 
                645                 650                 655     


Asn Val Glu Asn Leu Ile Lys Glu Leu Lys Val Ser Asp Glu Glu Ile 
            660                 665                 670         


Ser Lys Ser Leu Asn Leu Asp Ile Ile Phe Glu Gly Lys Val Asp Ile 
        675                 680                 685             


Ile Asn Lys Ile Asn Asn Leu Lys Ile Gly Glu Tyr Lys Asp Lys Lys 
    690                 695                 700                 


Tyr Leu Pro Ser Phe Ser Lys Ile Val Pro Glu Ile Thr Arg Lys Phe 
705                 710                 715                 720 


Arg Glu Ile Asn Lys Asp Lys Ser Phe Asp Ile Glu Ser Glu Lys Ile 
                725                 730                 735     


Ile Leu Asn Ala Val Lys Tyr Val Asn Lys Ile Leu Tyr Glu Lys Ile 
            740                 745                 750         


Thr Ser Asn Glu Glu Asn Glu Phe Ile Lys Thr Leu Pro Asp Lys Leu 
        755                 760                 765             


Val Lys Lys Asn Asn Asn Lys Glu Asn Lys Asn Ser Leu Ser Ile Glu 
    770                 775                 780                 


Glu Tyr Tyr Lys Asn Ala Gln Val Ser Ser Ser Lys Gly Asp Lys Lys 
785                 790                 795                 800 


Ala Ile Lys Lys Tyr Gln Asn Lys Val Thr Asn Ala Tyr Leu Glu Tyr 
                805                 810                 815     


Leu Glu Asn Thr Phe Ala Glu Val Ile Asn Phe Ser Asn Phe Asn Leu 
            820                 825                 830         


Asn Phe Asp Glu Ile Lys Thr Lys Ile Glu Glu Arg Lys Tyr Ser Lys 
        835                 840                 845             


Ser Lys Ile Thr Val Asp Ser Ile Ser Thr Asn Ile Asn Ile Thr Asn 
    850                 855                 860                 


Asp Ile Glu Tyr Ile Ile Ser Ile Phe Ala Leu Leu Asn Ser Asn Thr 
865                 870                 875                 880 


Tyr Ile Asn Lys Ile Arg Asn Arg Phe Phe Ala Thr Ser Val Trp Leu 
                885                 890                 895     


Glu Lys Gln Asn Ser Thr Lys Glu Tyr Asp Tyr Glu Asn Ile Ile Asp 
            900                 905                 910         


Ile Leu Asp Lys Val Leu Ser Ile Asn Leu Leu Arg Glu Asn Asn Ile 
        915                 920                 925             


Ala Asp Ile Leu Asp Leu Lys Asn Thr Ile Ile Glu Thr Lys Ile Val 
    930                 935                 940                 


Glu Asn Asn Glu Glu Cys Ile Arg Asn Tyr Ile Phe Glu Asn Asn Glu 
945                 950                 955                 960 


Glu Lys Leu Lys Lys Arg Leu Phe Cys Glu Glu Leu Val Asp Glu Glu 
                965                 970                 975     


Asp Ile Arg Lys Ile Phe Glu Asp Lys Asn Phe Lys Phe Lys Asn Phe 
            980                 985                 990         


Ile Lys Lys Thr Glu Asn Glu Asn  Phe Thr Ile Asn Phe  Asp Asn Leu 
        995                 1000                 1005             


Phe Asn  Leu Glu Cys Asn Ser  Glu Leu Asn Val Lys  Lys Val Ile 
    1010                 1015                 1020             


Gly Gln  Asn Ser Gln Arg Leu  Asn Leu Phe Ile Lys  Asn Thr Ile 
    1025                 1030                 1035             


Asp Glu  Tyr Lys Ser Lys Ile  Lys Thr Ser Phe Ser  Ser Glu Phe 
    1040                 1045                 1050             


Leu Glu  Lys Tyr Lys Gly Ile  Ile Asp Asn Leu Ile  Glu Asn Glu 
    1055                 1060                 1065             


Asn Lys  Phe Glu Lys Ile Tyr  Tyr Pro Glu Glu His  Lys Asn Glu 
    1070                 1075                 1080             


Leu Tyr  Ile Tyr Lys Lys Asn  Leu Phe Leu Asn Ile  Gly Asn Pro 
    1085                 1090                 1095             


Asn Phe  Asp Lys Ile Tyr Arg  Ile Ile Ser Glu Asp  Ile Lys Asn 
    1100                 1105                 1110             


Val Asn  Thr Glu Ile Leu Phe  Asp Asn Asp Ile Arg  Asn Asn Lys 
    1115                 1120                 1125             


Ile Ala  Lys Ile Asp Val Ile  Leu Lys Asn Leu Asn  Asp Lys Leu 
    1130                 1135                 1140             


Asn Gly  Tyr Ser Gln Gly Tyr  Lys Glu Lys Tyr Ile  Glu Lys Leu 
    1145                 1150                 1155             


Lys Glu  Asn Ser Asp Phe Phe  Thr Lys Asn Ile Gln  Asn Glu Asn 
    1160                 1165                 1170             


Tyr Asn  Ser Phe Glu Glu Phe  Lys Glu Asp Tyr Asn  Lys Val Ser 
    1175                 1180                 1185             


Glu Tyr  Lys Arg Ile Arg Asp  Leu Val Glu Phe Asn  Tyr Leu Asn 
    1190                 1195                 1200             


Lys Ile  Glu Ser Tyr Leu Ile  Asp Ile Asn Trp Lys  Leu Ala Ile 
    1205                 1210                 1215             


Gln Met  Ala Arg Phe Glu Arg  Asp Met His Tyr Ile  Val Asn Gly 
    1220                 1225                 1230             


Leu Asp  Tyr Leu Tyr Ile Ile  Arg Leu Glu Lys Asn  Arg Asn Gln 
    1235                 1240                 1245             


Asp Arg  Ser Ser Pro Tyr Pro  Lys Tyr Lys Asn Gly  Val Leu Asp 
    1250                 1255                 1260             


Tyr Thr  Lys Ser Tyr Tyr Asn  Phe Lys Asp Tyr Gln  Glu Phe Met 
    1265                 1270                 1275             


Asp Ile  Cys Ser Lys Phe Gly  Ile Asp Leu Ser Glu  Asn Ser Glu 
    1280                 1285                 1290             


Ile Asn  Lys Pro Glu Asn Glu  Ser Ile Arg Asn Tyr  Ile Ser His 
    1295                 1300                 1305             


Phe Tyr  Ile Val Arg Asn Pro  Phe Ala Asp Tyr Ser  Ile Ala Glu 
    1310                 1315                 1320             


Gln Ile  Asp Arg Val Ser Asn  Leu Leu Ser Tyr Ser  Thr Arg Tyr 
    1325                 1330                 1335             


Asn Asn  Ser Thr Tyr Ala Ser  Val Phe Glu Val Phe  Lys Lys Asp 
    1340                 1345                 1350             


Val Asp  Leu Asp Tyr Asp Glu  Leu Lys Lys Lys Phe  Lys Leu Ile 
    1355                 1360                 1365             


Gly Asn  Asn Asp Ile Leu Glu  Arg Leu Met Lys Pro  Lys Lys Val 
    1370                 1375                 1380             


Ser Val  Leu Glu Leu Glu Ser  Tyr Asn Ser Asn Tyr  Ile Lys Asn 
    1385                 1390                 1395             


Leu Ile  Ile Glu Leu Leu Thr  Lys Val Glu Asn Lys  Asp Glu Ile 
    1400                 1405                 1410             


Phe Ser  
    1415 


<210>  23
<211>  1169
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  23

Met Gly Ser Gly Lys Tyr Arg Ile Thr Lys Ile Ala Arg Asp Trp Asp 
1               5                   10                  15      


Glu Asn Lys Lys Arg Ile Ile Leu Lys Arg Ile Val Ser Asp Gly Glu 
            20                  25                  30          


Val Lys Tyr Val Asn Glu Asn Asn Asn Val Asp Ile Asp Ile Thr Glu 
        35                  40                  45              


Thr Tyr Tyr Arg Ile Leu Ser Asn Asn Lys Ala Lys Phe Leu Gly Ser 
    50                  55                  60                  


Asn Glu Gln Phe Ile Phe Lys Val Asn Lys Met Lys Arg Asn Ile Lys 
65                  70                  75                  80  


Asn Asp Cys Val Ile Ile Lys Asp Tyr Thr Glu Glu Glu Phe Glu Lys 
                85                  90                  95      


Leu Asp Lys Lys Ile Phe Phe Ser Arg Lys Ile Lys Val Asn Asn Lys 
            100                 105                 110         


Asp Arg Glu Lys Ile Cys Arg Asn Phe Tyr Glu Asp Glu Arg Glu Ile 
        115                 120                 125             


Met Lys Lys Arg Leu Glu Glu Ala Lys Lys Phe Asn Asn Ile Ile Phe 
    130                 135                 140                 


Asn Ile Cys Asn Lys Ile Phe Lys Leu Glu Tyr Leu Asp Tyr Thr Asp 
145                 150                 155                 160 


Glu Lys Val Tyr Lys Ile Phe Gln Asn Glu Ile Lys Val Lys Asp Val 
                165                 170                 175     


Lys Asn Leu Lys Glu Ala Phe Lys Gln Gln Glu Lys Gly Leu Glu Thr 
            180                 185                 190         


Asp Lys Leu Leu Ala Ile Ser Phe Asn Lys Lys Arg Asn Asn Ile Leu 
        195                 200                 205             


Leu Glu Phe Ile Gln Gln Ile Ala Lys Gln Glu Phe Glu Asn Gln Lys 
    210                 215                 220                 


Glu Leu Glu Asn Trp Phe Ser Tyr Gly Gly Glu Lys Tyr Cys Lys Glu 
225                 230                 235                 240 


Ile Phe Lys Ile Tyr Ser Asn Met Ser Gln Lys Glu Lys Tyr Phe Lys 
                245                 250                 255     


Leu Leu Gly His Arg Asn Gln Gly Ile Ala Ser Ile Tyr Asp Glu Lys 
            260                 265                 270         


Lys Glu Thr Leu Gln Arg Arg Leu Lys Leu Gly Asp Tyr Ser Lys Tyr 
        275                 280                 285             


Asp Leu Lys Arg Tyr Tyr Gln Lys Asp Tyr Lys Glu Glu Ala Ile Lys 
    290                 295                 300                 


Glu Leu Lys Asp Lys Asn Lys Glu Gly Leu Glu Arg Glu Ile Glu Glu 
305                 310                 315                 320 


Leu Ile Lys Lys Asn Tyr Lys Ile Asp Lys Leu Cys Asp Glu Ile Ser 
                325                 330                 335     


Asn Leu Glu Phe Ser Phe Val Glu Ser Lys Lys Glu Asn Lys Asp Lys 
            340                 345                 350         


Met Ser Glu Ile Ile Val Lys Ile Lys Glu His Tyr Lys Lys Asn Val 
        355                 360                 365             


Asn Val Glu Glu Glu Leu Glu Asn Lys Glu Lys Tyr Ile Leu Ser Ile 
    370                 375                 380                 


Ile His Asn Tyr Val Lys Gly Arg Tyr Arg Lys Cys Leu Glu Leu Gln 
385                 390                 395                 400 


Gln Lys Glu Asn Val Asp Phe Glu Asn Leu Glu Lys Arg Ile Lys Glu 
                405                 410                 415     


Ile Phe Asp Ser Asn Glu Val Thr Lys Lys Leu Lys Lys Ser Ile Ile 
            420                 425                 430         


Asn Lys Val Asn Ser Tyr Lys Ile Phe Glu Met Lys Phe Gln Asn Pro 
        435                 440                 445             


Asn Val Glu Ser Ser Asp Asp Leu Glu Ile Leu Lys Ala Glu Glu Thr 
    450                 455                 460                 


Phe Leu Asn Lys Leu Ser Thr Ala Val Ser Lys Val Gly Tyr Ile Leu 
465                 470                 475                 480 


Asn Ile Leu Leu Glu Ile His Phe Arg Asn Asp Ile Leu Gln Asp Tyr 
                485                 490                 495     


Asn Gln Val Glu Lys Leu Trp Lys Ser Asp Ser Phe Gln Lys Ile Cys 
            500                 505                 510         


Ala Ile Tyr Pro Glu Ile Asn Asn Asp Glu Lys Leu Leu Lys Gly Met 
        515                 520                 525             


Ile Tyr Phe Ile Gln Gly Leu Arg Gln Gln Val Leu His Pro Lys Ile 
    530                 535                 540                 


Leu Trp Glu Lys Gln Asn Ile Tyr Asn Ala Glu Asn Ile Lys Glu Lys 
545                 550                 555                 560 


Glu Lys Ile Val Ser Val Lys Leu Gln Asn Glu Gly Glu Ala Tyr Asn 
                565                 570                 575     


Lys Lys Gly Ile Gln Asn Tyr Phe Glu Asn Val Leu Lys Lys Ile Pro 
            580                 585                 590         


Asp Tyr Phe Ile Glu Lys Tyr Glu Ser Asn Asn Val Phe Asn Ile Tyr 
        595                 600                 605             


Arg Asn Ser Val Asp Lys Ile Met Glu Val Val Lys Asn Phe Asn Phe 
    610                 615                 620                 


Lys Glu Asn Asn Thr Ile Asp Tyr Leu Phe Pro Lys Phe His Lys Ile 
625                 630                 635                 640 


Tyr Lys Arg Met Cys Lys Ser Glu Asn Ile Asp Asp Arg Gln Asn Gly 
                645                 650                 655     


Ala Arg Lys Tyr Leu Leu Gln Thr Ile Tyr Tyr Tyr Tyr Phe Gln Tyr 
            660                 665                 670         


Glu Ile Glu Asn Asp Lys Asn Asn Met Ser Lys Tyr Leu Asn Leu Tyr 
        675                 680                 685             


Arg Asn Lys Ile Lys Val Lys Lys Ile Ser Tyr Ser Tyr Ile Ile Asp 
    690                 695                 700                 


Asn Lys Ala Val Asn Asn Lys Asn Ile Glu Ile Leu Tyr Arg Asn Ile 
705                 710                 715                 720 


Gln Arg Glu Gly Met Leu Asn Asn Arg Leu Leu Gln Met Asn Asn Glu 
                725                 730                 735     


Trp Ile Glu Phe Ile Val Val Gln Phe Ser Glu Phe Leu Thr Lys Lys 
            740                 745                 750         


Lys Leu Asn Trp Ile Leu Asp Asp Leu Ser Glu Tyr Lys Lys Lys Glu 
        755                 760                 765             


Lys Leu Asp Glu Asn Asp Lys Asn Glu Leu Leu Lys Ile Phe Lys Gln 
    770                 775                 780                 


Lys Met Asn Lys Asn Ile Thr Tyr Ser Asn Asp Ser Tyr Ala Phe Ile 
785                 790                 795                 800 


Ser Leu Ala Gln Phe Leu Asp Leu Lys Glu Ile Ser Asn Leu Ile His 
                805                 810                 815     


Asp Ile Lys Lys Phe Val Gln Phe Arg Glu Lys Asn Ile Leu Lys Tyr 
            820                 825                 830         


Asn Pro Glu Lys Asn Lys Ile Tyr Ile Glu Glu Leu Arg Lys Ile Leu 
        835                 840                 845             


Tyr Ile Leu Lys Val Met Leu Glu His Lys Glu Arg Val Ile Gln Lys 
    850                 855                 860                 


His Tyr Leu Gly Ser Tyr Asp Glu Asp Ile Ser Ile Met Tyr Gly Lys 
865                 870                 875                 880 


Asp Ile Glu Lys Lys Asp Ile Lys Asp Ile Glu Ile Lys Ile Lys Asn 
                885                 890                 895     


Lys Asn Gln Glu Val Ile Asn Gln Pro Leu Tyr Lys Ser Gly Asn Asp 
            900                 905                 910         


Glu Asn Ser Ser Trp Ile Ile Leu Tyr Gly Ile Glu Gln Ala Lys Arg 
        915                 920                 925             


Asn Gly Thr Phe Lys Phe Phe Glu Gly Phe Phe Asn Leu Asn Asp Asp 
    930                 935                 940                 


Ile Lys Leu Cys Lys Glu Asp Ile Glu Lys Tyr Glu Lys Leu Tyr Asn 
945                 950                 955                 960 


Glu Lys Glu Glu Asn Gln Lys Lys Val Asp Glu Tyr Ile Ser Lys Leu 
                965                 970                 975     


Asn Asn Asp Ile Glu Lys Ile Asn Asn Asp Ile Asn Ile Glu Lys Thr 
            980                 985                 990         


Asn Asp Asn Lys Gln Leu Phe Tyr  Tyr Tyr Lys Asn Met  Ile Tyr Gly 
        995                 1000                 1005             


Asp Gly  Leu Lys Lys Gly Tyr  Asp Phe Ile Asn Asp  Ile Tyr Ser 
    1010                 1015                 1020             


His Tyr  Leu Ser Trp Ala Tyr  Arg Ile Glu Arg Asp  Cys Lys Ile 
    1025                 1030                 1035             


Tyr Lys  Ile Lys Glu Tyr Glu  Asn Lys Lys Asn Phe  Asn Glu Tyr 
    1040                 1045                 1050             


Lys Phe  Lys Glu Tyr Lys Ser  Ile Lys Tyr Phe Arg  Asn Glu Ile 
    1055                 1060                 1065             


Ala His  Phe Asn Tyr Phe Gln  Lys Thr Asn Lys Ser  Leu Leu Glu 
    1070                 1075                 1080             


Leu Leu  Asn Asn Phe Tyr Asp  Ile Phe Asp Tyr Asn  Leu Lys Tyr 
    1085                 1090                 1095             


Gln Arg  Asp Val Gln Lys Val  Ile Asn Asn Ile Phe  Glu Lys Tyr 
    1100                 1105                 1110             


Gln Val  Ile Arg Glu Asp Gly  Gly Pro Val Ile Phe  Tyr Cys Lys 
    1115                 1120                 1125             


Ile Asp  Lys Lys Leu Lys Leu  Ser Glu Asn Ile Ile  Pro Lys Lys 
    1130                 1135                 1140             


His Leu  Lys Cys Ser Lys Ile  Lys Leu Ile His Glu  Lys Tyr Val 
    1145                 1150                 1155             


Glu Phe  Phe Arg Lys Leu Phe  Glu Tyr Lys Lys 
    1160                 1165                 


<210>  24
<211>  1165
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  24

Met Gly Ser Gly Lys Tyr Arg Ile Thr Lys Ile Ala Arg Lys Trp Asp 
1               5                   10                  15      


Lys Asn Glu Asn Trp Glu Lys Ile Ile Leu Lys Arg Ile Val Asp Asn 
            20                  25                  30          


Lys Lys Ile Lys Tyr Val Asn Glu Asn Asn Asn Lys Asp Val Asp Ile 
        35                  40                  45              


Thr Asp Thr Tyr Tyr Ser Ile Leu Ser Lys Asn Asn Ser Lys Phe Leu 
    50                  55                  60                  


Gly Ser Glu Glu Gln Phe Ile Phe Lys Val Asn Lys Met Lys Arg Asn 
65                  70                  75                  80  


Ile Lys Asn Asp Cys Val Ile Ile Lys Asp Tyr Thr Glu Glu Glu Phe 
                85                  90                  95      


Glu Lys Phe Asp Lys Lys Ile Phe Phe Ser Arg Lys Ile Lys Val Asn 
            100                 105                 110         


Asn Glu Asp Arg Glu Lys Ile Cys Arg Asn Phe Tyr Glu Asp Glu Arg 
        115                 120                 125             


Glu Ile Met Lys Lys Arg Leu Glu Glu Ala Lys Asn Phe Asn Asn Ile 
    130                 135                 140                 


Ile Phe Asn Ile Cys Asn Lys Ile Phe Lys Leu Glu Tyr Ile Asp Tyr 
145                 150                 155                 160 


Thr Asp Glu Lys Val Tyr Glu Ile Phe Gln Lys Glu Ile Lys Phe Glu 
                165                 170                 175     


Asp Ile Lys Asn Leu Lys Glu Ala Phe Lys Gln Gln Glu Asn Gly Leu 
            180                 185                 190         


Glu Thr Asp Lys Leu Leu Thr Ile Ser Phe Asn Lys Lys Arg Ser Asn 
        195                 200                 205             


Val Leu Leu Glu Phe Ile Gln Gln Ile Val Lys Gln Asn Phe Glu Asn 
    210                 215                 220                 


Glu Lys Glu Leu Glu Asn Trp Phe Ser His Asp Gly Glu Lys Tyr Cys 
225                 230                 235                 240 


Lys Glu Ile Phe Lys Ile Tyr Ser Asn Met Ser Gln Lys Glu Lys Tyr 
                245                 250                 255     


Ser Lys Leu Leu Gly His Asn Asp Lys Ser Ile Ala Ser Asn Ser Glu 
            260                 265                 270         


Lys Arg Glu Thr Leu Gln Arg Arg Leu Lys Leu Gly Asp Tyr Ser Lys 
        275                 280                 285             


Tyr Asp Leu Lys Lys Tyr Tyr Gln Lys Asp Tyr Lys Glu Glu Ala Ile 
    290                 295                 300                 


Lys Glu Leu Glu Asp Lys Ser Lys Glu Glu Leu Glu Lys Glu Val Glu 
305                 310                 315                 320 


Glu Ile Ile Lys Lys Asn Tyr Lys Ile Asp Lys Leu Cys Asp Glu Ile 
                325                 330                 335     


Ser Asn Leu Glu Phe Ser Phe Val Asp Ser Lys Lys Glu Asn Lys Asp 
            340                 345                 350         


Lys Met Ser Glu Ile Ile Val Lys Ile Lys Glu His Tyr Lys Asn Asn 
        355                 360                 365             


Val Asn Val Glu Glu Glu Leu Glu Asn Lys Glu Lys Tyr Ile Leu Ser 
    370                 375                 380                 


Val Ile His Asn Tyr Ile Lys Gly Arg Tyr Arg Lys Cys Leu Glu Leu 
385                 390                 395                 400 


Gln Gln Lys Glu Asn Val Asp Phe Glu Asn Leu Gly Lys Arg Ile Lys 
                405                 410                 415     


Glu Ile Phe Asp Ser Asn Lys Val Thr Glu Lys Leu Lys Lys Ser Ile 
            420                 425                 430         


Leu Asn Lys Val Asn Asn Tyr Lys Ile Phe Glu Thr Lys Phe Gln Asn 
        435                 440                 445             


Pro Asn Ile Glu Ser Ser Asp Asp Leu Glu Ile Leu Lys Ala Glu Glu 
    450                 455                 460                 


Thr Phe Leu Asn Lys Leu Ser Thr Ala Val Ser Lys Val Gly Tyr Ile 
465                 470                 475                 480 


Leu Asn Ile Leu Leu Glu Ile His Phe Arg Asn Asp Ile Leu Gln Asp 
                485                 490                 495     


Tyr Asn Gln Val Glu Lys Leu Trp Lys Ser Asp Ser Phe Gln Lys Ile 
            500                 505                 510         


Cys Ala Ile Tyr Pro Glu Ile Asn Asn Asp Glu Lys Leu Leu Lys Gly 
        515                 520                 525             


Met Ile Tyr Phe Ile Gln Gly Leu Arg Gln Gln Val Leu His Pro Lys 
    530                 535                 540                 


Ile Leu Trp Glu Lys Gln Asn Ile Tyr Asn Ala Glu Asn Ile Lys Glu 
545                 550                 555                 560 


Lys Glu Lys Ile Val Ser Val Arg Leu Gln Asn Glu Gly Glu Ala Tyr 
                565                 570                 575     


Asn Lys Lys Gly Ile Gln Asn Tyr Phe Glu Asn Val Leu Lys Lys Ile 
            580                 585                 590         


Pro Asp Tyr Phe Ile Glu Lys Tyr Glu Ser Ser Asn Val Phe Asn Ile 
        595                 600                 605             


Tyr Arg Asn Phe Val Asp Lys Ile Met Glu Val Val Lys Asn Phe Asn 
    610                 615                 620                 


Phe Lys Glu Asn Asn Thr Ile Asp Tyr Leu Phe Pro Lys Phe His Lys 
625                 630                 635                 640 


Ile Tyr Lys Arg Met Cys Lys Leu Glu Asn Ile Asp Asp Arg Gln Asn 
                645                 650                 655     


Gly Ala Arg Lys Tyr Leu Leu Gln Ile Ile Tyr Tyr Tyr Tyr Phe Gln 
            660                 665                 670         


Tyr Glu Ile Glu Asn Asp Lys Asn Asn Ile Ser Lys Tyr Leu Asn Leu 
        675                 680                 685             


Tyr Arg Asn Lys Ile Lys Val Lys Lys Ile Ser Tyr Ser Tyr Ile Thr 
    690                 695                 700                 


Asp Asn Lys Ala Val Asn Asn Lys Asn Ile Glu Ile Leu Tyr Arg Asn 
705                 710                 715                 720 


Ile Gln Arg Glu Gly Met Leu Asn Asn Lys Leu Ser Gln Met Asn Lys 
                725                 730                 735     


Glu Trp Ile Glu Phe Ile Val Val Gln Phe Ser Glu Phe Leu Thr Asn 
            740                 745                 750         


Lys Lys Leu Asn Trp Ile Leu Asp Asn Leu Ser Glu Tyr Lys Lys Lys 
        755                 760                 765             


Glu Lys Leu Asp Glu Asn Asp Lys Asn Arg Leu Leu Lys Ile Leu Lys 
    770                 775                 780                 


Gln Lys Met Asn Lys Lys Ile Ile Tyr Ser Asn Asp Ser Tyr Ala Phe 
785                 790                 795                 800 


Ile Ser Leu Ala Gln Phe Leu Asp Leu Lys Glu Ile Ser Asn Leu Ile 
                805                 810                 815     


His Asp Ile Lys Lys Phe Ile Gln Phe Arg Glu Lys Asn Val Ser Lys 
            820                 825                 830         


Tyr Lys Pro Glu Lys Asn Lys Leu Tyr Ile Lys Glu Leu Arg Lys Val 
        835                 840                 845             


Leu Tyr Ile Leu Lys Val Met Leu Glu His Lys Glu Arg Val Ile Gln 
    850                 855                 860                 


Lys His Tyr Leu Glu Ser Tyr Asp Glu Asn Ile Ser Ile Ile Tyr Gly 
865                 870                 875                 880 


Lys Asp Ile Glu Arg Lys Asp Ile Lys Asp Ile Lys Ile Lys Ile Lys 
                885                 890                 895     


Asn Glu Asn Gln Glu Ile Ile Asn Gln Pro Leu Tyr Lys Ser Gly Asn 
            900                 905                 910         


Asp Glu Asn Ser Ser Trp Ile Val Leu Tyr Gly Ile Glu Gln Ala Lys 
        915                 920                 925             


Arg Asn Gly Thr Phe Lys Phe Phe Glu Gly Phe Phe Asn Leu Asn Asp 
    930                 935                 940                 


Asp Ile Lys Leu Cys Lys Glu Asn Ile Glu Lys Tyr Glu Glu Leu Tyr 
945                 950                 955                 960 


Asn Glu Lys Glu Glu Asn Gln Arg Lys Val Asp Glu Tyr Ile Ser Ser 
                965                 970                 975     


Glu Glu Asn Asn Asn Ile Asp Glu Ile Lys Glu Ile Asn Asn Asn Lys 
            980                 985                 990         


Gln Leu Phe Tyr Tyr Tyr Lys Asn  Met Ile Tyr Gly Asp  Gly Leu Lys 
        995                 1000                 1005             


Lys Gly  Tyr Asn Phe Ile Asn  Asp Ile Tyr Ser His  Tyr Leu Ser 
    1010                 1015                 1020             


Trp Ala  Tyr Arg Val Glu Arg  Asp Cys Lys Ile Tyr  Lys Ile Lys 
    1025                 1030                 1035             


Glu Tyr  Glu Asn Lys Lys Asn  Phe Asn Glu Tyr Lys  Phe Lys Glu 
    1040                 1045                 1050             


Tyr Lys  Ser Ile Lys Asn Phe  Arg Asn Glu Ile Ala  His Phe Asn 
    1055                 1060                 1065             


Tyr Phe  Gln Lys Thr Asn Lys  Ser Leu Leu Glu Leu  Leu Asn Asp 
    1070                 1075                 1080             


Phe Tyr  Asp Ile Phe Asp Tyr  Asn Leu Lys Tyr Gln  Arg Asp Val 
    1085                 1090                 1095             


Gln Asn  Val Ile Asn Asn Ile  Phe Glu Lys Tyr Gln  Ile Val Arg 
    1100                 1105                 1110             


Lys Asp  Gly Gly Pro Val Val  Phe Tyr Cys Lys Thr  Asp Lys Lys 
    1115                 1120                 1125             


Leu Lys  Leu Ser Glu Asn Leu  Val Pro Lys Lys His  Ser Lys Tyr 
    1130                 1135                 1140             


Pro Glu  Ile Lys Leu Ile His  Glu Lys Tyr Val Met  Phe Phe Arg 
    1145                 1150                 1155             


Lys Leu  Phe Glu Tyr Lys Lys  
    1160                 1165 


<210>  25
<211>  1095
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  25

Met Lys Val Thr Lys Ile Asp Gly Leu Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ile Glu Asp Ala Ser Gln Lys Asn Glu Thr 
            20                  25                  30          


Leu Glu Arg Leu Glu Lys Leu Lys Glu Ile Lys Leu Gly Asn Tyr Ile 
        35                  40                  45              


Lys Asn Pro Asp Lys Thr Lys Asp Lys Asp Asn Lys Lys Arg Arg Lys 
    50                  55                  60                  


Gly Leu Lys Glu Tyr Phe Ser Glu Ile Thr Leu Arg Lys Glu Asn Glu 
65                  70                  75                  80  


Lys Tyr Val Leu Leu Lys Gly Lys Lys Leu Lys Lys Ile Asn Asn Asp 
                85                  90                  95      


Ile Lys Asp Thr Asp Ile Lys Val Lys Tyr Lys Lys Glu Glu Val Phe 
            100                 105                 110         


Asp Val Leu Lys Lys Ile Leu Lys Leu Asn Leu Leu Ala Asn Asp Val 
        115                 120                 125             


Glu Glu Lys Ile Gln Phe Asp Ser Ile Lys Leu Lys Asn Val Phe Gly 
    130                 135                 140                 


Lys Asp Phe Val Lys Lys Glu Leu Gln Ile Lys Ser Ile Glu Glu Ser 
145                 150                 155                 160 


Leu Glu Lys Asn Lys Ala Asp Tyr Arg Lys Glu Phe Ile Glu Ile Glu 
                165                 170                 175     


Asn Asp Lys Tyr Gly Asn Val Lys Gly Glu Asn Lys Lys Asn Arg Ile 
            180                 185                 190         


Tyr Glu Tyr Tyr Lys Lys Ser Glu Thr His Glu Lys Phe Arg Lys Asn 
        195                 200                 205             


Ile Ile Glu Ala Phe Glu Lys Leu Tyr Lys Lys Asp Asp Ile Glu Lys 
    210                 215                 220                 


Leu Tyr Thr Gln Ile Ile Glu Ile Ser Lys Lys Met His Leu Lys Ser 
225                 230                 235                 240 


Lys Val Arg Glu Leu Tyr Lys Asn Val Ile Ile Lys Arg Ser Cys Asp 
                245                 250                 255     


Asp Phe Ser Lys Lys Asn Lys Glu Gly Ile Ser Val Leu Tyr Ser Gln 
            260                 265                 270         


Ile Met Asn Ser Val Lys Lys Asn Glu Lys Phe Val Lys Phe Val Lys 
        275                 280                 285             


Asn Ile Glu Leu Lys Asp Leu Thr Lys Ser Gln Ile Phe Tyr Lys Tyr 
    290                 295                 300                 


Phe Leu Glu Asn Glu Glu Leu Asn Asp Glu Asn Ile Lys Asn Ile Phe 
305                 310                 315                 320 


Cys Tyr Phe Val Glu Ile Glu Val Ser Asp Leu Leu Lys Gly Asn Val 
                325                 330                 335     


Tyr Lys Val Ser Lys Ile Tyr Glu Asn Lys Ile Lys Asn Ile Phe Glu 
            340                 345                 350         


Tyr Asn Lys Leu Lys Lys Leu Val Ile Asn Lys Leu Glu Asn Lys Leu 
        355                 360                 365             


Asn Asn Tyr Val Arg Asn Cys Gly Lys Tyr Asn Tyr His Met Glu Asn 
    370                 375                 380                 


Gly Asp Ile Ala Thr Ser Asp Ile Asn Met Arg Asn Arg Gln Thr Glu 
385                 390                 395                 400 


Ala Phe Leu Arg Ser Met Ile Gly Val Ser Ser Phe Gly Tyr Phe Ser 
                405                 410                 415     


Leu Arg Asn Ile Leu Gly Val Asn Asp Asp Asp Phe Tyr Glu Ile Glu 
            420                 425                 430         


Glu Asp Leu Thr Glu Glu Glu Arg Lys Asn Glu Ser Asn Val Leu Lys 
        435                 440                 445             


Lys Ala Lys Glu Asp Ile Thr Ser Lys Ser Ile Phe Glu Lys Val Val 
    450                 455                 460                 


Asp Lys Ser Phe Glu Lys Lys Gly Ile His Ser Ile Arg Glu Asn Val 
465                 470                 475                 480 


Lys Met Phe Tyr Gly Asp Ser Phe Asp Lys Ala Asn Glu Asp Glu Leu 
                485                 490                 495     


Lys Gln Phe Phe Val Asn Met Leu Asn Ala Ile Thr Ser Ile Arg His 
            500                 505                 510         


Arg Val Val His Tyr Asn Met Asn Thr Asn Ser Glu Asn Ile Phe Asn 
        515                 520                 525             


Phe Ser Asp Ile Glu Val Ser Arg Leu Leu Lys Ser Ile Phe Glu Lys 
    530                 535                 540                 


Glu Thr Asp Lys Arg Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn 
545                 550                 555                 560 


Ser Ala Gly Val Phe Asp Tyr Trp Glu Asn Trp Lys Ile Lys Lys Tyr 
                565                 570                 575     


Leu Glu Asn Met Lys Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val 
            580                 585                 590         


Pro Ser Phe Thr Lys Leu Tyr Asn Arg Ile Asp Asn Leu Lys Gly Ser 
        595                 600                 605             


Asn Ala Leu Asn Leu Gly Tyr Ile Asn Ile Pro Lys Arg Lys Glu Ala 
    610                 615                 620                 


Arg Asp Ser Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Lys Phe 
625                 630                 635                 640 


Val Glu Glu Phe Ile Lys Asn Asn Asp Asn Phe Glu Lys Ile Phe Arg 
                645                 650                 655     


Glu Ile Ile Glu Ile Asn Lys Asn Ala Gly Thr Asn Lys Gln Thr Asn 
            660                 665                 670         


Phe Tyr Lys Leu Glu Lys Phe Glu Lys Leu Lys Ala Asn Thr Pro Thr 
        675                 680                 685             


Glu Tyr Leu Glu Lys Leu Gln Ser Leu His Lys Ile Asn Tyr Asn Arg 
    690                 695                 700                 


Glu Lys Ile Glu Glu Asp Lys Asp Ile Tyr Val Asp Phe Val Gln Lys 
705                 710                 715                 720 


Ile Phe Leu Lys Gly Phe Ile Ser Tyr Leu Gln Lys Ser Asn Ser Leu 
                725                 730                 735     


Lys Pro Leu Asn Leu Leu Asn Leu Lys Lys Asp Glu Val Ile Asn Ser 
            740                 745                 750         


Glu Lys Ser Phe Tyr Asp Glu Lys Leu Lys Gln Trp Glu Asn Asn Gly 
        755                 760                 765             


Ser Asn Leu Ser Glu Met Pro Lys Glu Ile Tyr Lys Tyr Ile Lys Glu 
    770                 775                 780                 


Ile Lys Ile Asn Lys Thr Asn Tyr Ser Asp Arg Met Ser Ile Phe Tyr 
785                 790                 795                 800 


Leu Leu Leu Lys Leu Ile Asp His Lys Glu Leu Thr Asn Leu Arg Gly 
                805                 810                 815     


Asn Leu Glu Lys Tyr Glu Ser Met Asn Lys Asn Lys Ile Tyr Ser Glu 
            820                 825                 830         


Glu Leu Asn Ile Val Asn Leu Val Ser Leu Asp Asn Asn Lys Val Arg 
        835                 840                 845             


Thr Asn Phe Ser Val Glu Ala Glu Asp Ile Gly Lys Phe Leu Lys Thr 
    850                 855                 860                 


Glu Thr Ser Ile Lys Asn Ile Asn Gln Leu Asn Asn Phe Ser Gly Ile 
865                 870                 875                 880 


Phe Ala Asp Gly Glu Asn Val Ile Lys His Arg Ser Phe Tyr Asn Ile 
                885                 890                 895     


Lys Lys Tyr Gly Ile Leu Asp Leu Leu Glu Lys Ile Val Ala Lys Ala 
            900                 905                 910         


Asp Leu Lys Ile Ala Lys Glu Glu Ile Lys Lys Tyr Glu Asn Leu Gln 
        915                 920                 925             


Lys Glu Leu Glu Lys Asn Asp Phe Tyr Lys Ile Gln Glu Lys Ile His 
    930                 935                 940                 


Arg Lys Tyr Asn Gln Lys Pro Asn Leu Ile Ser Arg Thr Glu Asn Lys 
945                 950                 955                 960 


Lys Asp Phe Asn Asp Tyr Lys Lys Ala Ile Glu Asn Ile Gln Asn Tyr 
                965                 970                 975     


Thr Gln Leu Lys Asn Lys Ile Glu Phe Asn Asp Leu Asn Leu Leu Gln 
            980                 985                 990         


Gly Leu Leu Phe Arg Ile Leu His  Arg Leu Thr Gly Tyr  Thr Ser Leu 
        995                 1000                 1005             


Trp Glu  Arg Asp Leu Gln Phe  Lys Leu Lys Gly Glu  Phe Pro Glu 
    1010                 1015                 1020             


Asp Lys  Tyr Ile Asp Glu Ile  Phe Asn Ser Asp Arg  Asn Asn Asn 
    1025                 1030                 1035             


Gln Lys  Tyr Lys Ser Gly Gly  Ile Ala Tyr Lys Tyr  Val Asp Phe 
    1040                 1045                 1050             


Leu Ile  Glu Lys Glu Glu Gly  Lys Arg Ala Gly Lys  Asn Lys Val 
    1055                 1060                 1065             


Lys Lys  Arg Ser Glu Arg Glu  Arg Ser Phe Ile Ile  Arg Asn Tyr 
    1070                 1075                 1080             


Ile Ala  His Phe Asn Tyr Ile  Pro Asp Ala Glu Lys  
    1085                 1090                 1095 


<210>  26
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  26

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Asn Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Asn Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Glu 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Val Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Thr Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Lys Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Glu  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  27
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  27

Met Gly Asn Leu Phe Gly His Lys Arg Trp Tyr Glu Val Arg Asp Lys 
1               5                   10                  15      


Glu Asn Tyr Lys Val Arg Arg Lys Val Lys Ile Lys Arg Asn Tyr Asp 
            20                  25                  30          


Gly Asn Lys Tyr Ile Leu Asn Ile Asn Glu Asn Ser Asn Lys Glu Lys 
        35                  40                  45              


Ile Asn Asn Asn Glu Phe Ile Arg Glu Phe Val Asn Tyr Lys Lys Asn 
    50                  55                  60                  


Asp Asn Val Phe Lys Glu Phe Lys Arg Lys Phe His Ala Gly Asn Ile 
65                  70                  75                  80  


Leu Phe Lys Leu Lys Gly Asn Lys Arg Ser Ile Glu Asp Ser Asn Asp 
                85                  90                  95      


Phe Leu Glu Thr Lys Glu Val Val Leu Asp Lys Glu Val Tyr Gly Gln 
            100                 105                 110         


Ser Glu Lys Leu Lys Asn Glu Glu Gly Ile Thr Lys Lys Asp Ile Leu 
        115                 120                 125             


Lys Glu Ile Asn Lys Gln Lys Ile Asp Asn Ser Val Lys Lys Ile Ser 
    130                 135                 140                 


Met Asn Thr Asn Ser Gly Lys Thr Ile Val Ile Asn Phe Ser Asp Lys 
145                 150                 155                 160 


Leu Lys Lys Asp Lys Asp Asp Tyr Gln Ile Thr Leu Asn Ile Ile Ser 
                165                 170                 175     


Glu Asp Glu Leu Glu Arg Lys Arg Lys Ile Tyr Asp Ile Phe Lys Met 
            180                 185                 190         


Ile Asn Met Asp Leu Tyr Gln Ile Ile Lys Glu Ile Ile Glu Asn Glu 
        195                 200                 205             


Val Gln Lys Val Phe Lys Asn Arg Tyr Tyr Glu Glu His Leu Arg Glu 
    210                 215                 220                 


Lys Leu Leu Lys Asp Asp Lys Ile Asp Val Ile Leu Thr Asn Phe Met 
225                 230                 235                 240 


Lys Ile Arg Glu Lys Ile Glu Asn Asn Pro Glu Ile Met Gly Phe Val 
                245                 250                 255     


Lys Phe Tyr Leu Asn Val Gly Gly Asp Lys Lys Lys Ser Glu Asn Lys 
            260                 265                 270         


Lys Ile Phe Val Glu Lys Ile Leu Asn Thr Asn Val Asp Leu Thr Val 
        275                 280                 285             


Glu Asp Val Val Asp Phe Ile Val Lys Glu Leu Lys Phe Trp Asn Ile 
    290                 295                 300                 


Thr Lys Arg Ile Glu Lys Val Lys Glu Phe Asn Asn Lys Ser Leu Glu 
305                 310                 315                 320 


Asn Lys Arg Asn Arg Thr Tyr Ile Lys Ser Tyr Val Ser Leu Asp Lys 
                325                 330                 335     


His Glu Lys Phe Lys Arg Asp Arg Glu Asn Lys Lys Asp Lys Ile Val 
            340                 345                 350         


Lys Leu Phe Val Lys Asp Ile His Asn Asn Thr Met Glu Glu Lys Ile 
        355                 360                 365             


Asn Gln Ile Leu Asn Lys Phe Lys Ile Lys Glu Leu Ile Glu Lys Leu 
    370                 375                 380                 


Lys Glu Asn Thr Glu Asn Lys Asn Phe Asp Thr Glu Ile Phe Gly Ile 
385                 390                 395                 400 


Phe Lys Thr His Tyr Gln Asn Ile Phe Ser Ser Glu Lys Phe Ser Asn 
                405                 410                 415     


Lys Ser Asp Glu Glu Lys Glu Leu Tyr Lys Ile Ile Tyr Arg Tyr Leu 
            420                 425                 430         


Lys Gly Arg Ile Glu Lys Ile Leu Ile Asn Glu Glu Lys Val Arg Leu 
        435                 440                 445             


Lys Lys Met Glu Lys Ile Glu Ile Glu Lys Ile Leu Asn Glu Ser Ile 
    450                 455                 460                 


Leu Ser Glu Lys Ile Leu Lys Arg Val Lys Gln Tyr Thr Leu Glu His 
465                 470                 475                 480 


Ile Met Tyr Leu Gly Lys Leu Ile His Asn Lys Ile Asn Met Ala Thr 
                485                 490                 495     


Val Asn Thr Asn Asp Phe Ser Arg Leu His Ala Lys Glu Glu Leu Asp 
            500                 505                 510         


Leu Glu Leu Ile Thr Phe Phe Ala Ser Thr Asn Met Glu Leu Asn Lys 
        515                 520                 525             


Ile Phe Asn Gly Lys Glu Lys Val Thr Asp Phe Phe Gly Ser Asn Leu 
    530                 535                 540                 


Asn Gly Gln Lys Ile Thr Leu Lys Glu Lys Val Pro Ser Phe Lys Leu 
545                 550                 555                 560 


Asn Ile Leu Lys Lys Leu Asn Phe Ile Asn Asn Glu Asn Asn Ile Asp 
                565                 570                 575     


Glu Lys Leu Ser His Phe Tyr Ser Phe Gln Lys Glu Gly Tyr Leu Leu 
            580                 585                 590         


Arg Asn Lys Ile Leu His Asn Ser Tyr Gly Asn Ile Gln Glu Thr Lys 
        595                 600                 605             


Asn Leu Glu Glu Lys Tyr Lys Asn Val Lys Asn Leu Ile Asp Glu Leu 
    610                 615                 620                 


Lys Val Ser Asp Glu Glu Ile Ser Lys Ser Leu Asn Leu Asp Val Ile 
625                 630                 635                 640 


Phe Glu Gly Lys Asn Asn Ile Ile Ile Glu Ile Asn Lys Leu Gln Thr 
                645                 650                 655     


Gly Lys Tyr Lys Asp Lys Lys Tyr Leu Pro Ser Phe Ser Lys Ile Val 
            660                 665                 670         


Pro Glu Ile Met Arg Lys Phe Arg Glu Ile Asn Lys Asp Lys Ser Phe 
        675                 680                 685             


Asp Ile Glu Ser Glu Lys Ile Ile Leu Asn Ala Val Gln Tyr Val Asn 
    690                 695                 700                 


Lys Ile Leu Tyr Glu Lys Ile Thr Ser Asn Glu Glu Asn Glu Phe Ile 
705                 710                 715                 720 


Lys Thr Leu Pro Asp Lys Leu Val Lys Lys Asn Asn Asn Lys Glu Asn 
                725                 730                 735     


Lys Asn Ser Leu Ser Ile Glu Glu Tyr Tyr Lys Asn Ala Gln Val Ser 
            740                 745                 750         


Ser Ser Lys Gly Asp Lys Lys Ala Ile Lys Lys Tyr Gln Ile Lys Val 
        755                 760                 765             


Thr Asn Ala Tyr Leu Glu Tyr Leu Glu Asn Thr Phe Thr Glu Val Ile 
    770                 775                 780                 


Asp Phe Ser Asn Phe Asn Leu Asn Phe Asp Glu Ile Lys Thr Lys Ile 
785                 790                 795                 800 


Glu Glu Arg Lys Tyr Ser Lys Ser Lys Ile Thr Ile Asp Ser Ile Ser 
                805                 810                 815     


Thr Asn Ile Asn Ile Thr Asn Asp Ile Glu Tyr Ile Ile Ser Ile Phe 
            820                 825                 830         


Ala Leu Leu Asn Ser Asn Thr Tyr Ile Asn Lys Ile Arg Asn Arg Phe 
        835                 840                 845             


Phe Ala Thr Ser Val Trp Leu Glu Lys Gln Asn Gly Ile Lys Glu Tyr 
    850                 855                 860                 


Asp Tyr Glu Asn Ile Ile Ser Ile Leu Asp Glu Val Leu Leu Thr Asn 
865                 870                 875                 880 


Leu Leu Arg Glu Asn Asn Val Thr Asp Ile Leu Asp Leu Lys Asn Ala 
                885                 890                 895     


Ile Ile Asp Ala Lys Ile Ala Glu Asn Asp Glu Thr Tyr Ile Lys Asn 
            900                 905                 910         


Tyr Ile Phe Glu Ser Asn Glu Glu Lys Leu Lys Lys Arg Leu Phe Cys 
        915                 920                 925             


Glu Glu Phe Val Asp Lys Glu Asp Ile Arg Lys Ile Phe Glu Asp Lys 
    930                 935                 940                 


Asn Phe Lys Phe Lys Asn Phe Ile Lys Lys Asn Glu Ile Gly Asn Phe 
945                 950                 955                 960 


Lys Ile Asn Phe Asp Val Leu Leu Asn Leu Glu Cys Asn Ser Glu Val 
                965                 970                 975     


Glu Val Lys Lys Val Ile Gly Gln Asn Ser Lys Lys Leu Glu Ser Phe 
            980                 985                 990         


Ile Gln Asn Thr Ile Asp Glu Tyr  Lys Ser Asn Ile Arg  Thr Leu Phe 
        995                 1000                 1005             


Ser Ser  Glu Phe Leu Glu Lys  Tyr Lys Glu Glu Ile  Asp Asn Leu 
    1010                 1015                 1020             


Val Glu  Asp Thr Glu Ser Glu  Asn Lys Asn Lys Phe  Glu Lys Ile 
    1025                 1030                 1035             


Tyr Tyr  Pro Lys Glu His Lys  Asn Glu Leu Tyr Ile  Tyr Lys Lys 
    1040                 1045                 1050             


Asn Leu  Phe Leu Asn Ile Gly  Asn Pro Asn Phe Asp  Lys Ile Tyr 
    1055                 1060                 1065             


Gly Ile  Ile Ser Lys Asp Ile  Lys Asn Ala Asn Thr  Glu Ile Leu 
    1070                 1075                 1080             


Phe Asp  Asp Asp Ile Arg Lys  Asn Lys Ile Ser Lys  Ile Asp Val 
    1085                 1090                 1095             


Ile Leu  Lys Asn Leu Asn Asn  Lys Leu Asn Gly Tyr  Ser Asn Asp 
    1100                 1105                 1110             


Tyr Lys  Glu Lys Tyr Val Asn  Lys Leu Lys Glu Asn  Asn Asp Phe 
    1115                 1120                 1125             


Phe Thr  Lys Asn Ile Gln Asn  Glu Asn Tyr Asn Ser  Phe Glu Glu 
    1130                 1135                 1140             


Phe Lys  Glu Asp Tyr Asn Lys  Val Ser Glu Tyr Lys  Lys Ile Arg 
    1145                 1150                 1155             


Asp Leu  Val Glu Phe Asn Tyr  Leu Asn Lys Ile Glu  Ser Tyr Leu 
    1160                 1165                 1170             


Ile Asp  Ile Asn Trp Lys Leu  Ala Ile Gln Met Ala  Arg Phe Glu 
    1175                 1180                 1185             


Arg Asp  Met His Tyr Ile Val  Asn Gly Leu Arg Glu  Leu Gly Ile 
    1190                 1195                 1200             


Ile Lys  Leu Asn Gly Tyr Asn  Thr Gly Ile Ser Arg  Ala Tyr Pro 
    1205                 1210                 1215             


Lys Arg  Asp Gly Ser Asp Asp  Phe Tyr Thr Thr Thr  Ala Tyr Tyr 
    1220                 1225                 1230             


Lys Phe  Phe Asp Glu Glu Ser  Tyr Lys Lys Phe Glu  Lys Ile Cys 
    1235                 1240                 1245             


Tyr Lys  Phe Gly Ile Asp Leu  Ser Glu Asn Ser Glu  Ile Asn Lys 
    1250                 1255                 1260             


Pro Glu  Asn Glu Ser Ile Arg  Asn Tyr Ile Ser His  Phe Tyr Ile 
    1265                 1270                 1275             


Val Arg  Asn Pro Phe Ala Asp  Tyr Ser Ile Val Glu  Gln Ile Asp 
    1280                 1285                 1290             


Arg Val  Ser Asn Leu Leu Ser  Tyr Ser Thr Arg Tyr  Asn Asn Ser 
    1295                 1300                 1305             


Thr Tyr  Ala Ser Val Phe Glu  Val Phe Lys Lys Asp  Val Asp Leu 
    1310                 1315                 1320             


Asp Tyr  Asp Lys Leu Lys Thr  Lys Phe Lys Leu Phe  Asp Asp Glu 
    1325                 1330                 1335             


Lys Asn  Asn Asp Ile Lys Ile  Leu Lys Ile Lys Asp  Leu Ile Glu 
    1340                 1345                 1350             


Ser Lys  Lys Val Ser Val Leu  Glu Leu Glu Ser Tyr  Asn Ser Asn 
    1355                 1360                 1365             


Tyr Val  Lys Asn Leu Ile Ile  Lys Leu Leu Thr Lys  Ile Glu Asn 
    1370                 1375                 1380             


Thr Asn  Asp Thr Leu 
    1385             


<210>  28
<211>  1199
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  28

Met Lys Val Thr Lys Ile Asp Gly Ile Ser His Lys Lys Phe Glu Asn 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Asp Asn Gln Gly Lys Asn Asn Glu 
            20                  25                  30          


Met Lys Glu Arg Leu Asn Lys Leu Lys Glu Leu Lys Leu Ser Asn Tyr 
        35                  40                  45              


Ile Lys Asn Pro Glu Asn Val Lys Asn Glu Asp Glu Asn Val Glu Lys 
    50                  55                  60                  


Glu Thr Lys Gln Arg Arg Lys Asn Leu Lys Asn Phe Phe Ser Glu Ile 
65                  70                  75                  80  


Ile Leu Arg Lys Glu Asn Glu Lys Tyr Val Leu Ile Lys Thr Lys Lys 
                85                  90                  95      


Phe Lys Asn Thr Asn Gln Glu Ile Asp Phe Tyr Asp Ile Lys Ser Lys 
            100                 105                 110         


Glu Lys Arg Gln Glu Ile Phe Asp Ala Leu Asn Gly Ile Leu Val Tyr 
        115                 120                 125             


Ile Glu Glu Asn Glu Lys Glu Glu Thr Ile Asn Phe Asp Ser Lys Lys 
    130                 135                 140                 


Leu Glu Lys Ala Phe Glu Asp Asp Phe Ile Lys Lys Glu Ala Lys Ile 
145                 150                 155                 160 


Lys Ala Ile Glu Lys Ser Leu Glu Ile Asn Arg Ala Asn Tyr Glu Lys 
                165                 170                 175     


Asp Tyr Val Glu Ile Glu Asn Asp Lys Tyr Ser Asp Val Lys Gly Thr 
            180                 185                 190         


Asn Lys Lys Ser Cys Val Tyr Glu Tyr Tyr Lys Lys Pro Glu Thr His 
        195                 200                 205             


Gln Lys Phe Ile Glu Asn Ile Lys Glu Ala Phe Glu Lys Leu Tyr Thr 
    210                 215                 220                 


Glu Lys Asn Ile Lys Glu Leu Leu Ser Lys Ile Glu Glu Ile Phe Asn 
225                 230                 235                 240 


Lys Thr His Leu Lys Ser Lys Val Arg Glu Phe Tyr Gln Asn Glu Ile 
                245                 250                 255     


Ile Gly Lys Ser Glu Phe Asn Lys Lys Asn Glu Glu Gly Val Ser Ile 
            260                 265                 270         


Leu Tyr Asn Gln Ile Ile Thr Ser Thr Glu Lys Lys Glu Lys Phe Thr 
        275                 280                 285             


Glu Phe Leu Lys Asn Ile Glu Leu Lys Asp Leu Thr Lys Ser Gln Val 
    290                 295                 300                 


Phe Tyr Lys Tyr Phe Leu Glu Asn Glu Glu Leu Asn Asp Glu Asn Ile 
305                 310                 315                 320 


Lys Tyr Ile Phe Cys His Phe Val Glu Ile Glu Val Asn Lys Leu Leu 
                325                 330                 335     


Lys Glu Asn Ile Tyr Lys Val Gly Lys Phe Asp Glu Val Asn Lys Asn 
            340                 345                 350         


Arg Ile Lys Asn Ile Phe Glu Tyr Arg Lys Leu Glu Asn Leu Ile Val 
        355                 360                 365             


Tyr Lys Leu Glu Asn Lys Leu Asn Thr Tyr Ile Arg Asn Cys Gly Lys 
    370                 375                 380                 


Tyr Asn Tyr His Met Glu Asn Gly Lys Met Ala Thr Ser Asp Ile Asn 
385                 390                 395                 400 


Met Lys Asn Arg Gln Thr Glu Ala Phe Leu Arg Ser Ile Ile Gly Val 
                405                 410                 415     


Ser Ser Phe Ser Tyr Phe Ser Leu Arg Asn Ile Leu Gly Val Asn Asp 
            420                 425                 430         


Asp Asp Phe Tyr Glu Ile Glu Glu Asn Ser Lys Glu Asp Glu Arg Lys 
        435                 440                 445             


Asn Glu Ser Asn Ile Leu Lys Lys Ala Lys Glu Asp Ile Thr Ser Lys 
    450                 455                 460                 


Ser Ile Phe Glu Lys Val Val Asp Lys Ser Phe Glu Lys Lys Gly Ile 
465                 470                 475                 480 


His Asn Leu Lys Glu Asn Leu Lys Met Phe Tyr Gly Asn Ser Phe Asp 
                485                 490                 495     


Glu Ala Asn Glu Glu Glu Leu Lys Gln Phe Phe Val Asn Met Leu Asn 
            500                 505                 510         


Ala Ile Thr Ser Ile Arg His Ser Ile Val His Tyr Asp Met Asn Thr 
        515                 520                 525             


Asn Ser Glu Asn Ile Phe Asn Phe Phe Asp Ile Glu Val Ser Lys Leu 
    530                 535                 540                 


Leu Lys Ser Ile Phe Glu Lys Glu Thr Asp Lys Arg Glu Leu Lys Leu 
545                 550                 555                 560 


Lys Val Phe Arg Gln Leu Asn Ser Ala Gly Val Phe Asp Tyr Trp Glu 
                565                 570                 575     


Asn Trp Lys Ile Lys Lys Tyr Leu Lys Asn Ile Glu Phe Lys Phe Ala 
            580                 585                 590         


Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys Leu Tyr Asn Arg 
        595                 600                 605             


Ile Asp Asn Leu Lys Gly Ser Asn Ala Leu Asn Leu Gly Tyr Ile Asn 
    610                 615                 620                 


Ile Pro Lys Arg Lys Glu Ala Arg Asp Ser Gln Ile Tyr Leu Leu Lys 
625                 630                 635                 640 


Asn Ile Tyr Tyr Gly Glu Phe Val Glu Lys Phe Val Asn Asn Asn Asp 
                645                 650                 655     


Asp Phe Glu Lys Ile Phe Arg Glu Ile Ile Lys Ile Asn Lys Asn Ala 
            660                 665                 670         


Gly Thr Asn Thr Lys Thr Lys Phe Tyr Lys Leu Glu Lys Phe Glu Val 
        675                 680                 685             


Leu Lys Ala Asn Thr Pro Thr Glu Tyr Leu Glu Lys Leu Gln Ser Leu 
    690                 695                 700                 


His Gln Ile Asn Tyr Asp Arg Glu Lys Ile Glu Glu Asp Lys Asp Ile 
705                 710                 715                 720 


Tyr Ile Asp Phe Val Gln Lys Ile Phe Leu Lys Gly Phe Ile Asn Tyr 
                725                 730                 735     


Leu Gln Glu Ser Asp Leu Leu Lys Pro Leu Asn Leu Leu Asn Leu Arg 
            740                 745                 750         


Lys Gly Glu Ala Ile Thr Asn Lys Lys Ser Phe Tyr Asp Glu Lys Leu 
        755                 760                 765             


Lys Leu Trp Gln Asn Asn Gly Ser Asn Leu Ser Lys Met Pro Lys Glu 
    770                 775                 780                 


Ile Tyr Asp Tyr Ile Lys Lys Ile Lys Ile Asn Lys Ile Asn Tyr Ser 
785                 790                 795                 800 


Asp Arg Met Ser Ile Phe Tyr Leu Leu Leu Lys Leu Ile Asp Tyr Arg 
                805                 810                 815     


Glu Leu Thr Asn Leu Arg Gly Asn Leu Glu Lys Tyr Glu Ser Met Asn 
            820                 825                 830         


Lys Asn Glu Ile Tyr Ser Glu Glu Leu Asn Ile Val Asn Leu Val Ser 
        835                 840                 845             


Leu Asp Asn Asn Lys Val Arg Ala Asn Phe Asn Leu Glu Pro Glu Asp 
    850                 855                 860                 


Ile Gly Lys Phe Leu Lys Thr Gly Thr Ser Ile Lys Asn Ile Asn Gln 
865                 870                 875                 880 


Leu Asn Asn Phe Ser Gly Ile Phe Ala Asp Arg Glu Asn Val Ile Lys 
                885                 890                 895     


His Arg Ser Phe Tyr Asn Ile Lys Lys Tyr Gly Ile Leu Asp Leu Leu 
            900                 905                 910         


Glu Lys Ile Val Ala Lys Ala Asp Leu Lys Ile Thr Lys Glu Glu Ile 
        915                 920                 925             


Lys Lys Tyr Lys Asn Leu Gln Lys Glu Leu Glu Lys Asn Asp Phe Tyr 
    930                 935                 940                 


Lys Ile Gln Glu Lys Ile His Arg Lys Tyr Asn Gln Lys Pro Asn Leu 
945                 950                 955                 960 


Ile Ser Lys Thr Glu Asn Glu Lys Asp Phe Asn Asp Tyr Glu Lys Ala 
                965                 970                 975     


Ile Glu Asn Ile Gln Asn Tyr Thr Gln Leu Lys Asn Lys Ile Glu Phe 
            980                 985                 990         


Asn Asp Leu Asn Leu Leu Gln Ser  Leu Leu Phe Arg Ile  Leu His Arg 
        995                 1000                 1005             


Leu Ala  Gly Tyr Thr Ser Leu  Trp Glu Arg Asp Leu  Gln Phe Lys 
    1010                 1015                 1020             


Leu Lys  Gly Glu Tyr Pro Glu  Asp Lys Tyr Ile Asp  Glu Ile Phe 
    1025                 1030                 1035             


Asn Phe  Asp Asn Ser Lys Asn  Lys Lys Tyr Lys Glu  Gly Ser Val 
    1040                 1045                 1050             


Ile Phe  Lys Tyr Ala Asp Phe  Leu Ile Glu Lys Glu  Glu Glu Lys 
    1055                 1060                 1065             


Ser Gly  Glu Ile Leu Lys Lys  Asn Lys Arg Asn Lys  Arg Arg Lys 
    1070                 1075                 1080             


Glu Ile  Ile Glu Lys Glu Gly  Leu Glu Ile Arg Asn  Tyr Ile Ala 
    1085                 1090                 1095             


His Phe  Asn Tyr Ile Pro Asp  Ala Glu Lys Ser Ile  Leu Glu Met 
    1100                 1105                 1110             


Leu Glu  Glu Leu Arg Asn Leu  Leu Lys Tyr Asp Arg  Lys Leu Lys 
    1115                 1120                 1125             


Asn Ala  Val Met Lys Ser Ile  Lys Asp Ile Phe Lys  Glu Tyr Gly 
    1130                 1135                 1140             


Phe Ile  Val Glu Phe Glu Ile  Ser His Glu Ser Asn  Ser Lys Lys 
    1145                 1150                 1155             


Ile Lys  Leu Leu Asn Val Lys  Ser Glu Lys Ile Lys  His Leu Lys 
    1160                 1165                 1170             


Asn Asn  Lys Leu Glu Thr Thr  Arg Asn Ser Glu Asp  Leu Cys Lys 
    1175                 1180                 1185             


Leu Val  Lys Val Met Leu Glu  Tyr Lys Lys Ser 
    1190                 1195                 


<210>  29
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  29

Met Lys Ile Thr Lys Ile Asp Gly Ile Ser His Lys Lys Tyr Ile Lys 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Lys Thr Asp Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Thr Ile Arg Leu Asp Thr Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Tyr Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Glu 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Ile Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Lys Ile Pro Tyr Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Asn Asp Lys Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Thr Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Glu Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Lys  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  30
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  30

Met Gly Thr Gly Lys Tyr Arg Ile Thr Lys Ile Gly Arg Asn Trp Lys 
1               5                   10                  15      


Glu Asn Glu Glu Thr Val Ile Leu Lys Arg Val Val Ser Asn Gly Lys 
            20                  25                  30          


Val Lys Tyr Ile Asn Glu Asn Asp Asn Val Asp Val Asn Ile Thr Glu 
        35                  40                  45              


Thr Tyr Tyr Arg Ile Leu Ser Asn Asn Lys Ala Arg Phe Leu Gly Ser 
    50                  55                  60                  


Lys Glu Gln Phe Ile Phe Lys Val Asn Lys Met Glu Arg Asn Ile Glu 
65                  70                  75                  80  


Asn Asp Cys Val Ile Ile Lys Asn Tyr Thr Glu Glu Glu Tyr Glu Lys 
                85                  90                  95      


Phe Asp Lys Lys Ile Phe Phe Lys Lys Arg Ile Lys Val Asn Asn Lys 
            100                 105                 110         


Asn Ile Glu Lys Ile Tyr Arg Asp Phe Tyr Glu Asp Glu Lys Gln Ile 
        115                 120                 125             


Met Lys Lys Arg Leu Glu Glu Ala Lys Asn Phe Asn Asn Ile Ile Phe 
    130                 135                 140                 


Asn Ile Cys Asn Lys Ile Phe Lys Leu Lys Tyr Leu Asp Tyr Thr Asn 
145                 150                 155                 160 


Glu Lys Val Tyr Lys Ile Phe Gln Asn Glu Ile Lys Val Lys Asp Ile 
                165                 170                 175     


Lys Asn Leu Lys Glu Ala Phe Lys Gln Gln Glu Lys Gly Leu Glu Thr 
            180                 185                 190         


Asp Lys Leu Leu Ala Ile Ser Phe Asn Lys Lys Arg Asn Asn Val Leu 
        195                 200                 205             


Leu Glu Phe Ile Gln Gln Ile Thr Lys Gln Glu Phe Lys Asn Gln Arg 
    210                 215                 220                 


Glu Leu Glu Asn Trp Phe Ser His Ser Gly Lys Lys Tyr Cys Lys Glu 
225                 230                 235                 240 


Ile Phe Lys Ile Tyr Ser Asn Met Ser Gln Lys Glu Lys Tyr Ser Lys 
                245                 250                 255     


Leu Leu Gly His Arg Asn Lys Asn Ile Ala Ser Ile Ser Glu Lys Lys 
            260                 265                 270         


Glu Thr Leu Gln Arg Arg Leu Lys Leu Glu Asn Tyr Ser Asp Tyr Asp 
        275                 280                 285             


Leu Arg Lys Tyr Tyr Gln Lys Asp Tyr Lys Glu Glu Ala Ile Lys Glu 
    290                 295                 300                 


Leu Lys Asp Lys Asn Lys Glu Glu Leu Glu Arg Glu Ile Glu Glu Leu 
305                 310                 315                 320 


Ile Lys Lys Asn Tyr Lys Ile Asp Lys Leu Cys Asp Glu Ile Ser Asn 
                325                 330                 335     


Leu Glu Phe Ser Phe Val Glu Ser Lys Lys Glu Asn Lys Asp Lys Met 
            340                 345                 350         


Ser Glu Ile Ile Val Lys Ile Lys Glu His Tyr Lys Lys Asn Val Asn 
        355                 360                 365             


Val Glu Glu Glu Leu Lys Asn Lys Glu Lys Tyr Ile Leu Ser Leu Ile 
    370                 375                 380                 


His Asn Tyr Val Lys Gly Arg Tyr Arg Lys Cys Leu Glu Leu Gln Gln 
385                 390                 395                 400 


Lys Glu Asn Ala Asp Phe Glu Asn Leu Gly Lys Arg Ile Lys Glu Ile 
                405                 410                 415     


Phe Asp Ser Asn Glu Val Thr Lys Lys Leu Lys Lys Ser Ile Ile Asn 
            420                 425                 430         


Lys Val Asn Ser Tyr Lys Ile Phe Glu Met Lys Phe Gln Asn Pro Asn 
        435                 440                 445             


Ile Glu Ser Ser Asp Asp Leu Glu Ile Leu Lys Ala Glu Glu Thr Phe 
    450                 455                 460                 


Leu Asn Lys Leu Ser Thr Ala Val Ser Lys Val Gly Tyr Thr Leu Asn 
465                 470                 475                 480 


Thr Leu Leu Glu Val Ser Pro Glu Lys Asp Ile Leu Glu Asn Tyr Lys 
                485                 490                 495     


Ala Val Glu Lys Leu Cys Asn Ser Asn Ser Thr Ile Glu Ile Tyr Lys 
            500                 505                 510         


Val Tyr Pro Glu Leu Glu Lys Asn Glu Lys Leu Leu Gln Gly Met Ile 
        515                 520                 525             


His Phe Ile Gln Gly Leu Arg Gln Gln Ser Leu His Pro Lys Ile Leu 
    530                 535                 540                 


Trp Asn Phe Glu Thr Lys Asn Leu Lys Pro Glu Lys Leu Glu Arg Leu 
545                 550                 555                 560 


Lys Glu Lys Lys Asn Ile Lys Met Arg Asp Cys Val Val His Glu Glu 
                565                 570                 575     


Asn Leu Asp Lys Lys Glu Lys Asn Glu Gly Glu Ile Lys Lys Tyr Phe 
            580                 585                 590         


Glu Lys Ile Glu Gly Lys Leu Pro Asp Tyr Phe Ile Glu Lys Tyr Glu 
        595                 600                 605             


Ser Asn Asn Val Phe Asn Ile Tyr Arg Asn Phe Val Asp Lys Ile Met 
    610                 615                 620                 


Glu Val Val Glu Asn Phe Asn Phe Lys Glu Asn Asn Thr Ile Asp Tyr 
625                 630                 635                 640 


Leu Phe Pro Lys Phe His Lys Ile Tyr Lys Arg Met Cys Lys Leu Glu 
                645                 650                 655     


Asn Ile Met Cys Lys Ser Glu Asn Ile Asp Asp Lys Arg Asn Gly Ala 
            660                 665                 670         


Arg Lys Tyr Leu Leu Gln Thr Ile Tyr Tyr Tyr Tyr Phe Gln Tyr Glu 
        675                 680                 685             


Ile Glu Asn Asn Lys Asn Asn Ile Ser Lys Tyr Leu Asn Leu Tyr Arg 
    690                 695                 700                 


Asn Lys Ile Glu Thr Glu Lys Asn Ser Tyr Ser Tyr Ile Ile Asp Asn 
705                 710                 715                 720 


Ile Asp Asp Ser Asn Lys Asn Ile Glu Ile Leu Tyr Arg Asn Leu Gln 
                725                 730                 735     


Arg Glu Gly Met Leu Asn Asn Lys Leu Leu Gln Ile Asn Asn Glu Trp 
            740                 745                 750         


Ile Glu Phe Ile Thr Val Gln Phe Ser Glu Phe Leu Thr Asp Lys Lys 
        755                 760                 765             


Leu Asn Trp Ile Ser Asp Glu Leu Leu Glu Tyr Glu Glu Lys Glu Lys 
    770                 775                 780                 


Leu Asp Asp Asn Asn Lys Asn Lys Leu Leu Glu Ile Leu Glu Lys Lys 
785                 790                 795                 800 


Leu Asn Lys Lys Ile Ala His Ser Asn Asp Ser Tyr Ala Phe Ile Ser 
                805                 810                 815     


Leu Ala Gln Phe Leu Asp Leu Lys Glu Ile Ser Asn Leu Ile His Asn 
            820                 825                 830         


Ile Lys Lys Phe Val Gln Phe Arg Glu Lys Asn Ile Ser Lys Tyr Lys 
        835                 840                 845             


Pro Glu Lys Asn Lys Val Tyr Ile Glu Glu Leu Arg Lys Ile Ser Tyr 
    850                 855                 860                 


Ile Leu Lys Ile Met Leu Glu His Lys Glu Arg Val Ile Gln Lys Arg 
865                 870                 875                 880 


Tyr Leu Glu Ser Tyr Ala Glu Asp Ile Ser Ile Ile Tyr Gly Lys Asp 
                885                 890                 895     


Ile Glu Lys Lys Asp Ile Lys Ala Leu Glu Ile Glu Ile Lys Lys Glu 
            900                 905                 910         


Asn Gln Gly Val Ile Gly Gln Pro Leu Tyr Lys Ser Gly Asn Asp Glu 
        915                 920                 925             


Asn Asn Ser Trp Ile Thr Leu Tyr Gly Ile Glu Gln Ala Lys Arg Asn 
    930                 935                 940                 


Gly Thr Phe Lys Phe Phe Glu Gly Phe Phe Asn Leu Asn Asp Asp Ile 
945                 950                 955                 960 


Lys Leu Cys Lys Lys Asp Ile Lys Arg Tyr Glu Lys Leu Tyr Asn Glu 
                965                 970                 975     


Lys Glu Asp Ser Gln Lys Val Val Asp Asp Tyr Ile Ser Leu Asn Glu 
            980                 985                 990         


His Ser Ser Ile Ser Thr Lys Glu  Leu Ile Lys Lys Asn  Cys Lys Lys 
        995                 1000                 1005             


Gln Leu  Phe Tyr Tyr Tyr Lys  Asn Met Ile Tyr Gly  Asp Gly Leu 
    1010                 1015                 1020             


Lys Lys  Gly Tyr Asp Phe Ile  Asn Asp Ile Tyr Ser  His Tyr Leu 
    1025                 1030                 1035             


Ser Trp  Ala Tyr Arg Ile Glu  Arg Asp Tyr Ser Ile  Tyr Lys Val 
    1040                 1045                 1050             


Glu Val  Tyr Asn Gly Lys Ile  Lys Asn Phe Arg Asn  Glu Ile Ala 
    1055                 1060                 1065             


His Phe  Asn Tyr Phe Gln Lys  Thr Asp Lys Ser Leu  Leu Asp Leu 
    1070                 1075                 1080             


Leu Asn  Asp Phe Tyr Asn Ile  Phe Asp Tyr Asn Leu  Lys Tyr Gln 
    1085                 1090                 1095             


Arg Asp  Ile Gln Lys Val Ile  Asn Asn Ile Phe Glu  Lys Tyr Gln 
    1100                 1105                 1110             


Val Val  Arg Glu Asp Gly Gly  Pro Val Ile Phe Tyr  Cys Lys Val 
    1115                 1120                 1125             


Asp Lys  Lys Leu Lys Leu Ser  Glu Asn Leu Val Pro  Lys Lys His 
    1130                 1135                 1140             


Ser Lys  Tyr Pro Glu Ile Glu  Leu Ile His Lys Lys  Tyr Val Ile 
    1145                 1150                 1155             


Phe Phe  Arg Lys Leu Phe Glu  Tyr Lys Lys 
    1160                 1165             


<210>  31
<211>  1372
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  31

Met Gly Asn Leu Phe Gly His Lys Lys Trp Tyr Lys Ala Asp Lys Ile 
1               5                   10                  15      


Ile Lys Asp Lys Lys Gly Lys Glu Ser Thr Ile Lys Gln Glu Val Arg 
            20                  25                  30          


Ile Lys Arg Asn Tyr Ser Val Asp Arg Tyr Thr Leu Asn Thr Asn Asn 
        35                  40                  45              


Lys Glu Lys Asn Asn Ile Asn Asn Glu Asp Phe Val Asn Gln Phe Ile 
    50                  55                  60                  


Glu Tyr Lys Thr Asn Asn Asp Ile Phe Lys Lys Phe Thr Arg Lys Phe 
65                  70                  75                  80  


His Met Gly Asn Ile Leu Phe Lys Leu Lys Gly Asn Lys Arg Ser Ile 
                85                  90                  95      


Glu Asp Ser Asn Asp Phe Leu Lys Thr Glu Glu Ile Ile Leu Asp Lys 
            100                 105                 110         


Glu Val Tyr Gly Gln Ser Glu Lys Leu Arg Asn Glu Lys Gly Ile Thr 
        115                 120                 125             


Lys Gln Gly Ile Leu Lys Glu Ile Asn Tyr Arg Gly Ile Asn Glu Ser 
    130                 135                 140                 


Asn Asp Ser Ile Leu Ile Lys Thr Lys Phe Gly Lys Glu Ile Lys Ile 
145                 150                 155                 160 


Asn Phe Thr Asp Glu Ala Lys Lys Asn Lys Asn Glu Tyr Gln Ile Thr 
                165                 170                 175     


Leu Lys Ile Ile Pro Glu Asn Glu Leu Lys Ile Lys Arg Glu Val Tyr 
            180                 185                 190         


Asp Val Phe Lys Met Ile Asn Met Asp Leu Tyr Gln Ile Ile Lys Glu 
        195                 200                 205             


Ile Ile Glu Asn Glu Val Gln Lys Val Phe Lys Asn Arg Tyr Tyr Glu 
    210                 215                 220                 


Glu Tyr Leu Arg Glu Lys Leu Leu Lys Asp Asp Lys Thr Gly Val Ile 
225                 230                 235                 240 


Leu Thr Asn Phe Ile Glu Ile Arg Glu Lys Ile Lys Ser Asn Leu Glu 
                245                 250                 255     


Ile Met Gly Phe Val Lys Phe Tyr Leu Asn Val Gly Gly Asp Lys Lys 
            260                 265                 270         


Lys Ser Glu Asn Lys Lys Ile Phe Val Glu Lys Ile Leu Asn Ile Asn 
        275                 280                 285             


Val Asp Leu Thr Val Glu Asp Ile Val Asp Phe Ile Val Lys Glu Leu 
    290                 295                 300                 


Lys Phe Trp Asn Ile Thr Lys Arg Ile Glu Lys Leu Gln Glu Lys Thr 
305                 310                 315                 320 


Val Asn Arg Ala Asp Glu Asp Ile Glu Asn Thr Tyr Ile Asn Thr Tyr 
                325                 330                 335     


Val Leu Leu Asp Lys His Glu Lys Phe Lys Lys Tyr Asn Arg Asn Lys 
            340                 345                 350         


Lys Asp Thr Ile Val Lys Ser Phe Ile Lys Asp Ile Lys Asp Asn Thr 
        355                 360                 365             


Met Lys Gln Lys Ile Asn Gln Ile Leu Arg Lys Phe Lys Ile Asp Glu 
    370                 375                 380                 


Leu Ile Lys Lys Thr Glu Lys Glu Leu Lys Arg Gly Asn Cys Asp Thr 
385                 390                 395                 400 


Glu Ile Phe Gly Ile Phe Lys Val His Tyr Gln Glu Met Phe Ser Ser 
                405                 410                 415     


Glu Lys Phe Glu Lys Lys Ser Asp Glu Glu Lys Glu Leu Tyr Lys Ile 
            420                 425                 430         


Ile Tyr Arg Tyr Leu Lys Gly Arg Ile Glu Lys Ile Leu Val Asn Glu 
        435                 440                 445             


Gln Lys Val Arg Leu Lys Lys Ile Glu Lys Ile Leu Asn Glu Ser Ile 
    450                 455                 460                 


Leu Ser Glu Lys Ile Leu Lys Arg Val Lys Gln Tyr Thr Leu Glu Tyr 
465                 470                 475                 480 


Ile Met Tyr Leu Gly Lys Leu Val His Asn Lys Ile Asn Met Ala Thr 
                485                 490                 495     


Val Asn Thr Asn Asp Phe Phe Arg Leu His Ala Lys Glu Glu Leu Asp 
            500                 505                 510         


Leu Glu Leu Ile Thr Phe Phe Ala Ser Thr Asn Met Glu Leu Asn Lys 
        515                 520                 525             


Ile Phe Asn Gly Lys Glu Lys Val Thr Asp Phe Phe Gly Phe Asn Leu 
    530                 535                 540                 


Asn Gly Gln Lys Ile Thr Leu Lys Glu Lys Val Pro Ser Phe Lys Leu 
545                 550                 555                 560 


Asn Ile Leu Lys Lys Leu Asn Phe Ile Asn Asn Glu Asn Asn Ile Asp 
                565                 570                 575     


Glu Lys Leu Ser His Phe Tyr Ser Phe Gln Lys Lys Gly Tyr Leu Leu 
            580                 585                 590         


Arg Asn Lys Ile Leu His Asn Ser Tyr Gly Asn Ile Gln Glu Thr Ile 
        595                 600                 605             


Asn Leu Lys Gly Glu Tyr Glu Asn Val Glu Asn Leu Ile Lys Glu Leu 
    610                 615                 620                 


Lys Val Ser Asn Glu Glu Ile Ser Lys Ser Leu Asn Leu Asp Ile Ile 
625                 630                 635                 640 


Phe Glu Gly Lys Val Asp Ile Ile Asn Lys Ile Asn Ser Leu Glu Ile 
                645                 650                 655     


Gly Glu Tyr Lys Asp Lys Lys Tyr Leu Pro Ser Phe Ser Lys Ile Val 
            660                 665                 670         


Pro Glu Ile Met Arg Lys Phe Arg Glu Ile Asn Lys Asp Lys Ser Phe 
        675                 680                 685             


Asp Ile Glu Ser Glu Lys Ile Ile Leu Asn Ala Val Gln Tyr Val Asn 
    690                 695                 700                 


Lys Ile Leu Tyr Glu Lys Ile Thr Ser Asn Glu Glu Asn Glu Phe Ile 
705                 710                 715                 720 


Lys Thr Leu Pro Asp Lys Leu Val Lys Lys Asn Asn Asn Lys Glu Asn 
                725                 730                 735     


Asn Asn Ser Leu Ser Ile Glu Glu Tyr Tyr Lys Asn Ala Gln Ile Ser 
            740                 745                 750         


Ser Ser Lys Gly Asp Lys Lys Ala Ile Lys Lys Tyr Gln Asn Lys Val 
        755                 760                 765             


Thr Asn Ala Tyr Ile Glu Tyr Leu Glu Asn Thr Phe Ala Glu Val Ile 
    770                 775                 780                 


Asp Phe Ser Asn Phe Asn Leu Asn Phe Asp Glu Ile Lys Thr Lys Ile 
785                 790                 795                 800 


Glu Glu Arg Lys Tyr Ser Lys Ser Lys Ile Thr Val Asp Ser Ile Ser 
                805                 810                 815     


Thr Asn Ile Asn Ile Thr Asn Asp Ile Glu Tyr Ile Ile Ser Ile Phe 
            820                 825                 830         


Ala Leu Leu Asn Ser Asn Thr Tyr Ile Asn Lys Ile Arg Asn Arg Phe 
        835                 840                 845             


Phe Ala Thr Ser Val Trp Leu Asp Lys Gln Asn Ser Thr Lys Glu Tyr 
    850                 855                 860                 


Asp Tyr Glu Asn Ile Ile Asp Ile Leu Asp Lys Ile Leu Ser Ile Asn 
865                 870                 875                 880 


Leu Leu Arg Glu Asn Asn Ile Ala Asp Ile Leu Asp Leu Lys Asn Thr 
                885                 890                 895     


Ile Ile Glu Ala Lys Ile Val Glu Asn Asn Glu Glu Cys Ile Lys Asn 
            900                 905                 910         


Tyr Ile Phe Glu Asn Asn Glu Glu Glu Leu Lys Lys Arg Leu Phe Cys 
        915                 920                 925             


Glu Glu Leu Val Asn Lys Glu Asp Val Leu Lys Ile Phe Glu Asp Lys 
    930                 935                 940                 


Asn Phe Lys Phe Lys Asn Phe Ile Lys Lys Thr Gly Asn Glu Asn Phe 
945                 950                 955                 960 


Thr Ile Asn Phe Asp Ile Leu Phe Asn Leu Glu Cys Asn Ser Glu Leu 
                965                 970                 975     


Asn Val Lys Lys Val Met Gly Gln Asn Ser Gln Arg Leu Asn Leu Phe 
            980                 985                 990         


Ile Lys Asn Thr Ile Asp Glu Tyr  Lys Ser Lys Ile Lys  Thr Ser Phe 
        995                 1000                 1005             


Ser Ser  Glu Phe Leu Glu Asn  Lys Asn Lys Phe Glu  Lys Ile Tyr 
    1010                 1015                 1020             


Tyr Pro  Lys Glu His Lys Asn  Glu Leu Tyr Ile Tyr  Lys Lys Asn 
    1025                 1030                 1035             


Leu Phe  Leu Asn Ile Gly Asn  Pro Asn Phe Asp Lys  Ile Tyr Glu 
    1040                 1045                 1050             


Leu Ile  Ser Lys Asp Ile Lys  Asn Ala Asn Thr Glu  Ile Leu Phe 
    1055                 1060                 1065             


Asp Asp  Asp Ile Arg Lys Asn  Lys Ile Ser Glu Ile  Asp Ala Ile 
    1070                 1075                 1080             


Leu Lys  Asn Leu Asn Asp Lys  Leu Asn Gly Tyr Ser  Asn Asp Tyr 
    1085                 1090                 1095             


Lys Ala  Lys Tyr Val Asn Lys  Leu Lys Glu Asn Asp  Asp Phe Phe 
    1100                 1105                 1110             


Ala Lys  Asn Met Lys Asn Glu  Asn Tyr Ser Ser Phe  Gly Glu Phe 
    1115                 1120                 1125             


Glu Lys  Asp Tyr Asn Lys Val  Ser Glu Tyr Lys Lys  Ile Arg Asp 
    1130                 1135                 1140             


Leu Val  Glu Phe Asn Tyr Leu  Asn Lys Ile Glu Ser  Tyr Leu Ile 
    1145                 1150                 1155             


Asp Ile  Asn Trp Lys Leu Ala  Ile Gln Met Ala Arg  Phe Glu Arg 
    1160                 1165                 1170             


Asp Met  His Tyr Ile Val Asn  Gly Leu Arg Glu Leu  Gly Ile Ile 
    1175                 1180                 1185             


Lys Leu  Ser Gly Tyr Asn Thr  Gly Ile Ser Arg Ala  Tyr Pro Lys 
    1190                 1195                 1200             


Arg Asn  Gly Ser Asp Gly Phe  Tyr Thr Thr Thr Ala  Tyr Tyr Lys 
    1205                 1210                 1215             


Phe Phe  Asp Glu Glu Ser Tyr  Lys Lys Phe Glu Lys  Ile Cys Tyr 
    1220                 1225                 1230             


Gly Phe  Gly Ile Asp Leu Ser  Glu Asn Ser Glu Ile  Asn Lys Pro 
    1235                 1240                 1245             


Glu Asn  Glu Ser Ile Arg Asn  Tyr Ile Ser His Phe  Tyr Ile Val 
    1250                 1255                 1260             


Arg Asn  Pro Phe Val Asp Tyr  Ser Ile Ala Glu Gln  Ile Asp Arg 
    1265                 1270                 1275             


Val Ser  Asn Leu Leu Ser Tyr  Ser Thr Arg Tyr Asn  Asn Ser Thr 
    1280                 1285                 1290             


Tyr Ala  Ser Val Phe Glu Val  Phe Lys Lys Asp Val  Asn Leu Asp 
    1295                 1300                 1305             


Tyr Asp  Lys Leu Lys Thr Lys  Phe Lys Leu Phe Asp  Asp Glu Lys 
    1310                 1315                 1320             


Asn Asp  Asn Ile Lys Ile Leu  Lys Ile Glu Asn Leu  Ile Glu Ser 
    1325                 1330                 1335             


Lys Lys  Val Ser Val Leu Glu  Leu Glu Ser Tyr Asn  Ser Asp Tyr 
    1340                 1345                 1350             


Ile Lys  Asn Leu Ile Ile Glu  Leu Leu Thr Lys Ile  Glu Asn Thr 
    1355                 1360                 1365             


Asn Asp  Thr Leu 
    1370         


<210>  32
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  32

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Gly Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Asn Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Lys Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys His Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr Tyr Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Glu 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Lys Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Lys Ile Pro His Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Ala Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Leu Lys Glu Leu Lys Glu Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn Tyr Arg Met Gln Gln Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Lys Lys Asp Glu Lys Phe Asn Asp Lys Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Thr Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Glu Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Lys  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  33
<211>  1208
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  33

Met Lys Val Thr Lys Ile Asp Gly Ile Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Arg Phe Thr Gly Asn Phe Asn Ile Lys Asn Glu 
            20                  25                  30          


Met Lys Glu Arg Leu Glu Lys Leu Lys Glu Leu Lys Leu Ser Asn Tyr 
        35                  40                  45              


Ile Lys Asn Pro Glu Asn Val Lys Asn Lys Asp Lys Asn Lys Glu Glu 
    50                  55                  60                  


Glu Thr Lys Ser Arg Arg Lys Asn Leu Lys Lys Tyr Phe Ser Glu Ile 
65                  70                  75                  80  


Ile Leu Arg Lys Lys Glu Glu Lys Tyr Leu Leu Lys Lys Thr Arg Lys 
                85                  90                  95      


Phe Lys Asp Ile Thr Glu Glu Ile Asn Tyr Asp Asp Ile Lys Lys Gly 
            100                 105                 110         


Glu Asn Gln Gln Lys Ile Phe Asp Val Leu Lys Glu Leu Leu Glu Gln 
        115                 120                 125             


Arg Ile Asn Glu Asn Asp Lys Glu Glu Ile Leu Asn Phe Asp Ser Val 
    130                 135                 140                 


Lys Leu Lys Glu Ala Phe Gly Glu Asp Phe Ile Lys Lys Glu Ser Lys 
145                 150                 155                 160 


Ile Lys Ala Ile Glu Glu Ser Leu Glu Lys Asn Arg Ala Asp Tyr Arg 
                165                 170                 175     


Lys Asp Tyr Val Glu Leu Glu Asn Glu Lys Tyr Glu Asp Val Lys Gly 
            180                 185                 190         


Gln Asn Lys Arg Ser Leu Val Phe Glu Tyr Tyr Lys Asn Pro Glu Asn 
        195                 200                 205             


Arg Glu Lys Phe Lys Glu Asn Ile Lys Tyr Ala Phe Glu Asn Leu Tyr 
    210                 215                 220                 


Thr Glu Glu Asn Ile Lys Asn Leu Tyr Ser Glu Ile Glu Glu Ile Phe 
225                 230                 235                 240 


Glu Lys Val His Leu Lys Ser Lys Val Arg Asp Phe Tyr Gln Asn Gly 
                245                 250                 255     


Ile Ile Gly Glu Ser Glu Phe Ser Glu Lys Asp Glu Glu Gly Ile Ser 
            260                 265                 270         


Ile Leu Tyr Lys Gln Ile Ile Asn Ser Val Glu Lys Lys Glu Lys Phe 
        275                 280                 285             


Val Glu Phe Leu Gln Lys Val Lys Ile Lys Asp Leu Thr Arg Ser Gln 
    290                 295                 300                 


Ile Phe Tyr Lys Tyr Phe Leu Glu Asn Glu Lys Leu Asn Asn Glu Asn 
305                 310                 315                 320 


Ile Lys Tyr Val Phe Ser Tyr Phe Val Glu Ile Glu Val Asn Lys Leu 
                325                 330                 335     


Leu Lys Glu Asn Val Tyr Lys Thr Lys Lys Phe Asn Glu Gly Asn Lys 
            340                 345                 350         


Tyr Arg Val Lys Asn Ile Phe Asn Tyr Asp Lys Leu Lys Asn Leu Val 
        355                 360                 365             


Val Tyr Lys Leu Glu Asn Lys Leu Asn Asn Tyr Ile Arg Asn Cys Gly 
    370                 375                 380                 


Lys Tyr Asn Tyr His Ile Glu Asn Gly Cys Val Ala Thr Ser Asp Thr 
385                 390                 395                 400 


Asn Met Lys Asn Arg Gln Ile Glu Ala Phe Leu Arg Ser Ile Leu Gly 
                405                 410                 415     


Val Ser Ser Phe Gly Tyr Phe Ser Leu Arg Asn Ile Leu Gly Val Asn 
            420                 425                 430         


Asp Asn Asp Phe Tyr Glu Met Glu Glu Glu Leu Thr Glu Asp Glu Arg 
        435                 440                 445             


Lys Asn Glu Asn Ser Ile Leu Lys Glu Asp Ser Ile Leu Lys Glu Ala 
    450                 455                 460                 


Lys Lys Asp Ile Thr Ser Lys Asp Asp Ile Phe Lys Lys Val Val Asp 
465                 470                 475                 480 


Lys Ser Phe Glu Lys Lys Gly Ile Tyr Gln Ile Lys Glu Asn Leu Lys 
                485                 490                 495     


Met Phe Tyr Gly Asn Ser Phe Asp Lys Val Asp Lys Asp Glu Leu Lys 
            500                 505                 510         


Lys Phe Phe Val Asn Met Leu Glu Ala Ile Thr Ser Val Arg His Arg 
        515                 520                 525             


Ile Val His Tyr Asn Ile Asn Thr Asn Ser Glu Asn Ile Phe Asp Phe 
    530                 535                 540                 


Ser Asn Ile Glu Val Ser Lys Leu Leu Lys Asn Ile Phe Glu Lys Glu 
545                 550                 555                 560 


Ile Asp Thr Arg Glu Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser 
                565                 570                 575     


Ala Gly Val Phe Asp Tyr Trp Glu Ser Trp Val Ile Lys Lys Tyr Leu 
            580                 585                 590         


Glu Asn Val Lys Phe Glu Phe Val Asn Lys Asn Val Pro Phe Val Pro 
        595                 600                 605             


Ser Phe Lys Lys Leu Tyr Asp Arg Ile Asp Asp Leu Lys Gly Trp Asn 
    610                 615                 620                 


Ala Leu Lys Leu Gly Asn Asn Ile Asn Ile Pro Lys Arg Lys Glu Ala 
625                 630                 635                 640 


Lys Asp Ser Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe 
                645                 650                 655     


Val Glu Lys Phe Val Asn Asp Asn Lys Asn Phe Glu Lys Ile Val Glu 
            660                 665                 670         


Glu Ile Ile Glu Ile Asn Arg Gly Ala Gly Thr Asn Lys Arg Thr Gly 
        675                 680                 685             


Phe Tyr Lys Leu Glu Lys Phe Glu Thr Leu Lys Ala Asn Thr Pro Thr 
    690                 695                 700                 


Glu Tyr Leu Glu Lys Leu Gln Ser Leu His Lys Ile Ser Tyr Asp Lys 
705                 710                 715                 720 


Glu Lys Ile Glu Glu Asp Lys Asp Ile Tyr Val Asp Phe Val Gln Lys 
                725                 730                 735     


Ile Phe Leu Lys Gly Phe Val Asn Tyr Leu Lys Lys Leu Asp Ser Leu 
            740                 745                 750         


Lys Ser Leu Asn Leu Leu Asn Leu Arg Lys Asp Glu Thr Ile Thr Asp 
        755                 760                 765             


Lys Lys Ser Val His Asp Glu Lys Leu Lys Leu Trp Glu Asn Ser Gly 
    770                 775                 780                 


Ser Asn Leu Phe Lys Met Pro Glu Glu Ile Tyr Glu Tyr Val Lys Lys 
785                 790                 795                 800 


Ile Lys Ile Ser Asn Ile Asn Tyr Asn Asp Arg Met Ser Ile Phe Tyr 
                805                 810                 815     


Leu Leu Leu Lys Leu Ile Asp Tyr Arg Glu Leu Thr Asn Leu Arg Gly 
            820                 825                 830         


Asn Leu Glu Lys Tyr Glu Ser Met Asn Lys Asn Lys Ile Tyr Ser Glu 
        835                 840                 845             


Glu Leu Thr Ile Ile Asn Leu Val Asn Leu Asp Asn Asn Lys Val Arg 
    850                 855                 860                 


Thr Asn Phe Ser Leu Glu Ala Glu Asp Ile Gly Lys Phe Leu Lys Ser 
865                 870                 875                 880 


Ser Ile Pro Ile Lys Asn Ile Ala Gln Leu Asn Asn Phe Ser Lys Ile 
                885                 890                 895     


Phe Ala Asp Gly Glu Asn Val Ile Lys His Lys Ser Phe Tyr Asn Ile 
            900                 905                 910         


Lys Lys Tyr Gly Ile Leu Asp Leu Leu Glu Lys Ile Val Ala Lys Ala 
        915                 920                 925             


Asp Leu Lys Ile Ala Lys Glu Glu Ile Lys Lys Tyr Glu Asn Leu Gln 
    930                 935                 940                 


Lys Glu Leu Glu Lys Asn Asp Phe Tyr Lys Ile Gln Glu Gln Ile His 
945                 950                 955                 960 


Arg Asn Tyr Asn Gln Asn Pro Phe Ser Ile Lys Lys Ile Glu Asn Lys 
                965                 970                 975     


Lys Asp Phe Glu Lys Tyr Lys Lys Val Ile Glu Lys Ile Gln Asp Tyr 
            980                 985                 990         


Thr Gln Leu Lys Asn Lys Ile Glu  Phe Asn Asp Leu Asn  Leu Leu Gln 
        995                 1000                 1005             


Ser Leu  Ile Phe Arg Ile Leu  His Arg Leu Ala Gly  Tyr Thr Ser 
    1010                 1015                 1020             


Leu Trp  Glu Arg Asp Leu Gln  Phe Lys Leu Lys Gly  Glu Phe Pro 
    1025                 1030                 1035             


Glu Asp  Lys Tyr Ile Asp Glu  Ile Phe Ser Phe Asp  Asn Asn Lys 
    1040                 1045                 1050             


Asn Glu  Lys Tyr Lys Asp Gly  Ser Ile Val Phe Lys  Tyr Ala Asp 
    1055                 1060                 1065             


Phe Leu  Ile Glu Lys Glu Glu  Glu Lys Leu Gly Glu  Val Leu Lys 
    1070                 1075                 1080             


Lys Asn  Lys Arg Asn Lys Arg  Lys Lys Glu Ile Ile  Glu Lys Asp 
    1085                 1090                 1095             


Gly Leu  Glu Ile Arg Asn Tyr  Ile Ala His Phe Asn  Tyr Leu Pro 
    1100                 1105                 1110             


Asn Ala  Glu Lys Ser Ile Leu  Glu Ile Leu Glu Glu  Leu Arg Glu 
    1115                 1120                 1125             


Leu Leu  Lys His Asp Arg Lys  Leu Lys Asn Ala Val  Met Lys Ser 
    1130                 1135                 1140             


Ile Lys  Asp Ile Phe Lys Glu  Tyr Gly Phe Ile Val  Glu Phe Thr 
    1145                 1150                 1155             


Ile Ser  His Thr Lys Asn Gly  Lys Lys Ile Lys Val  Cys Ser Val 
    1160                 1165                 1170             


Lys Ser  Glu Lys Ile Lys His  Leu Lys Asn Asn Glu  Leu Ile Thr 
    1175                 1180                 1185             


Thr Arg  Asn Ser Lys Asp Leu  Cys Glu Leu Val Lys  Ile Met Leu 
    1190                 1195                 1200             


Glu Tyr  Lys Glu Ala 
    1205             


<210>  34
<211>  1403
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  34

Met Gly Asn Leu Phe Gly Tyr Lys Lys Trp Tyr Lys Val Asp Lys Ile 
1               5                   10                  15      


Ile Lys Asp Lys Lys Gly Lys Lys Ser Thr Ile Lys Gln Glu Val Arg 
            20                  25                  30          


Ile Lys Arg Asn Tyr Leu Thr Asn Arg Tyr Ile Leu Asn Thr Asn Asn 
        35                  40                  45              


Lys Asp Lys Asn Asn Ile Asn Asn Glu Asp Phe Val Asp Gln Phe Ile 
    50                  55                  60                  


Glu Tyr Lys Thr Lys Asn Asp Ile Phe Glu Lys Phe Thr Arg Lys Phe 
65                  70                  75                  80  


His Met Gly Asn Ile Leu Phe Lys Leu Lys Gly Asn Lys Arg Ser Ile 
                85                  90                  95      


Glu Asp Ser Asn Asp Phe Leu Lys Thr Glu Glu Val Val Leu Asp Lys 
            100                 105                 110         


Glu Ile Tyr Gly Gln Ser Glu Lys Leu Arg Asn Glu Lys Gly Ile Thr 
        115                 120                 125             


Lys Gln Gly Ile Leu Lys Glu Ile Ile Asp Lys Gly Ile Asn Glu Ser 
    130                 135                 140                 


Asn Asp Ser Ile Leu Ile Lys Thr Lys Phe Gly Lys Glu Ile Lys Ile 
145                 150                 155                 160 


Asn Phe Thr Asp Glu Ser Lys Lys Asn Lys Asn Glu Tyr Gln Ile Thr 
                165                 170                 175     


Leu Lys Val Ile Pro Glu Asn Glu Leu Lys Ile Lys Arg Glu Val Tyr 
            180                 185                 190         


Asp Val Phe Lys Met Ile Asn Met Asp Leu Tyr Gln Ile Ile Lys Glu 
        195                 200                 205             


Ile Ile Glu Asn Glu Val Gln Lys Val Phe Lys Asn Arg Tyr Tyr Glu 
    210                 215                 220                 


Glu Tyr Leu Arg Glu Lys Leu Leu Glu Asp Asn Gln Ile Asn Val Ile 
225                 230                 235                 240 


Leu Thr Asn Phe Met Lys Ile Arg Glu Lys Thr Lys Ser Asn Ser Glu 
                245                 250                 255     


Ile Met Gly Phe Val Lys Phe Tyr Leu Asn Val Gly Gly Asp Lys Lys 
            260                 265                 270         


Lys Ser Glu Asn Lys Lys Met Phe Val Glu Lys Ile Leu Asn Ile Asn 
        275                 280                 285             


Val Asp Leu Thr Glu Glu Asp Ile Val Asp Phe Ile Val Lys Glu Leu 
    290                 295                 300                 


Lys Phe Tyr Gly Ile Ile Lys Arg Ile Glu Lys Leu Gln Glu Lys Lys 
305                 310                 315                 320 


Ala Asp Arg Thr Asp Lys Asp Ile Lys Lys Thr Tyr Ile Asn Thr Tyr 
                325                 330                 335     


Val Ser Leu Asp Lys His Glu Lys Phe Lys Lys Tyr Asn Arg Asn Lys 
            340                 345                 350         


Lys Asp Thr Ile Val Lys Ser Phe Ile Lys Asp Ile Lys Asp Asn Thr 
        355                 360                 365             


Met Lys Gln Lys Ile Asn Gln Ile Leu Arg Lys Phe Lys Ile Glu Glu 
    370                 375                 380                 


Leu Ile Asn Lys Leu Arg Ile Glu Asn Lys Asn Phe Asp Thr Glu Ile 
385                 390                 395                 400 


Phe Arg Ile Phe Lys Glu His Tyr Gln Glu Ile Phe Asn Ser Glu Lys 
                405                 410                 415     


Phe Glu Glu Lys Ser Asp Glu Glu Lys Glu Leu Tyr Lys Ile Ile Tyr 
            420                 425                 430         


Arg Tyr Leu Lys Gly Arg Ile Glu Lys Ile Leu Ile Asn Glu Gln Lys 
        435                 440                 445             


Val Arg Leu Lys Lys Met Glu Lys Ile Glu Val Glu Lys Ile Leu Asn 
    450                 455                 460                 


Glu Ser Ile Leu Ser Glu Lys Ile Leu Lys Arg Val Lys Gln Tyr Thr 
465                 470                 475                 480 


Leu Glu His Val Met Tyr Leu Gly Lys Leu Val His Asn Asp Ile Asp 
                485                 490                 495     


Arg Ser Ile Val Asn Thr Asn Asp Phe Ser Arg Leu His Ala Lys Glu 
            500                 505                 510         


Glu Leu Asp Leu Glu Leu Ile Thr Phe Phe Ala Ser Thr Asn Met Glu 
        515                 520                 525             


Leu Asn Lys Ile Phe Ser Arg Lys Asp Glu Tyr Glu Glu Asn Thr Asp 
    530                 535                 540                 


Phe Phe Gly Glu Gly Ala Phe Ser Asn Lys Lys Arg Glu Lys Ile Thr 
545                 550                 555                 560 


Leu Asn Lys Lys Ser Leu Asn Ser Lys Ile Lys Met Ile Arg Glu Leu 
                565                 570                 575     


Asp Phe Ile Asp Asn Lys Asn Glu Ile Ile Arg Glu Asn Phe Phe Glu 
            580                 585                 590         


Lys Phe Ile Lys Ile Gly Ala Asn Glu Arg Asn Arg Ile Leu His Ala 
        595                 600                 605             


Ser Asn Lys Arg Arg Val Pro Gln Gly Thr Gln Asp Asp Tyr Asn Lys 
    610                 615                 620                 


Val Ile Asn Ile Ile Gln Asn Leu Lys Ile Ser Asp Glu Glu Val Ser 
625                 630                 635                 640 


Lys Ala Leu Asn Leu Asp Val Val Phe Lys Asp Lys Lys Asn Ile Ile 
                645                 650                 655     


Thr Lys Ile Asn Asp Ile Glu Ile Ser Glu Glu Asn Asn Ser Ile Ile 
            660                 665                 670         


Lys Tyr Leu Pro Ser Phe Ser Lys Val Leu Pro Glu Ile Leu Asn Leu 
        675                 680                 685             


Tyr Lys Asn Glu Asn Lys Asn Asn Pro Phe Asp Thr Ile Glu Thr Glu 
    690                 695                 700                 


Lys Ile Ile Gln Asn Ala Leu Ile Tyr Val Asn Lys Glu Leu Tyr Lys 
705                 710                 715                 720 


Lys Leu Ile Ser Glu Lys Asn Leu Glu Glu Asn Glu Ser Lys Asn Lys 
                725                 730                 735     


Phe Leu Lys Glu Leu Lys Lys Asn Leu Ser Gly Thr Asp Glu Thr Asp 
            740                 745                 750         


Glu Asn Ile Ile Glu Asn Tyr Tyr Lys Asn Ala Gln Ile Ser Ala Ser 
        755                 760                 765             


Lys Gly Asn Asn Lys Ala Ile Lys Lys Tyr Gln Lys Lys Val Ile Glu 
    770                 775                 780                 


Cys Tyr Val Gly Tyr Leu Arg Lys Asn Tyr Glu Glu Leu Phe Asp Phe 
785                 790                 795                 800 


Ser Asp Phe Lys Met Asn Ile Gln Glu Ile Lys Lys Gln Ile Lys Asp 
                805                 810                 815     


Ile Ser Asp Asn Lys Thr Tyr Glu Arg Ile Thr Ile Lys Thr Ser Asp 
            820                 825                 830         


Lys Ser Ile Val Ile Asn Asp Asp Phe Glu Tyr Ile Ile Ser Ile Phe 
        835                 840                 845             


Ala Leu Leu Asn Ser Asn Ala Val Ile Asn Lys Ile Arg Asn Arg Phe 
    850                 855                 860                 


Phe Ala Thr Ser Val Trp Leu Asn Thr Ser Glu Tyr Gln Asn Ile Ile 
865                 870                 875                 880 


Asp Val Leu Asp Glu Ile Met Gln Leu Asn Thr Leu Arg Asn Glu Cys 
                885                 890                 895     


Ile Thr Glu Asn Trp Asn Leu Asn Leu Glu Glu Phe Ile Gln Lys Met 
            900                 905                 910         


Lys Asp Ile Glu Lys Glu Phe Glu Asp Phe Lys Ile Gln Thr Lys Lys 
        915                 920                 925             


Asp Ile Phe Asn Thr Asn Tyr Glu Gly Ile Lys Asn Ser Val Leu Asn 
    930                 935                 940                 


Lys Phe Ile Glu Phe Ser Asp Val Gln Lys Ile Leu Glu Gly Lys Leu 
945                 950                 955                 960 


Asn Glu Leu Ile Glu Phe Glu Asn Asp Asn Glu Ile Lys Lys Lys Ile 
                965                 970                 975     


Asn Leu Asn Ser Leu Asp Ile Asp Glu Arg Lys Asn Leu Met Ser Asn 
            980                 985                 990         


Ile Asp Gln Lys Lys Leu Ile Lys  Glu Ile Asp Lys Leu  Ile Val Thr 
        995                 1000                 1005             


Glu Lys  Asn Asn Ile Glu Lys  Asn Ile Leu Leu Lys  Leu Ile Phe 
    1010                 1015                 1020             


Asn Ser  Asn Phe Leu Glu Lys  Tyr Lys Lys Glu Ile  Asp Asn Leu 
    1025                 1030                 1035             


Ile Glu  Asp Thr Glu Ser Glu  Asn Glu Asn Lys Phe  Glu Lys Ile 
    1040                 1045                 1050             


Tyr Tyr  Pro Glu Glu His Lys  Asn Glu Leu Tyr Ile  Tyr Lys Lys 
    1055                 1060                 1065             


Asn Leu  Phe Leu Asn Ile Glu  Asn Pro Asn Phe Asp  Lys Ile Tyr 
    1070                 1075                 1080             


Gly Ile  Ile Ser Glu Asp Ile  Lys Asn Val Asp Thr  Lys Ile Leu 
    1085                 1090                 1095             


Phe Ala  Asp Asp Ile Arg Asn  Asn Lys Ile Val Glu  Thr Asp Gly 
    1100                 1105                 1110             


Ile Leu  Lys Asn Leu Asn Asn  Lys Leu Asn Gly Tyr  Ser Lys Glu 
    1115                 1120                 1125             


Tyr Lys  Glu Lys Tyr Val Asn  Lys Leu Lys Glu Asn  Asn Asp Phe 
    1130                 1135                 1140             


Phe Ile  Lys Asn Val Gln Asn  Glu Asn Tyr Lys Ser  Phe Glu Gly 
    1145                 1150                 1155             


Phe Glu  Glu Asp Tyr Asn Arg  Val Ser Glu Tyr Lys  Lys Ile Arg 
    1160                 1165                 1170             


Asp Leu  Val Glu Phe Asn Tyr  Leu Asn Lys Ile Glu  Ser Tyr Leu 
    1175                 1180                 1185             


Ile Asp  Ile Asn Trp Lys Leu  Ala Ile Gln Met Thr  Arg Phe Glu 
    1190                 1195                 1200             


Arg Asp  Met His Tyr Ile Val  Asn Gly Leu Asp Tyr  Leu Tyr Ile 
    1205                 1210                 1215             


Leu Arg  Leu Glu Arg Asp Arg  Asn Gln Asn Ile Ser  Ser Pro Tyr 
    1220                 1225                 1230             


Pro Lys  Tyr Lys Tyr Ile Asp  Lys Glu Asp Lys Ile  Lys Gly Arg 
    1235                 1240                 1245             


Lys Leu  Asp Tyr Ser Thr Ser  Tyr Tyr Asn Phe Lys  Asp Tyr Gln 
    1250                 1255                 1260             


Glu Phe  Met Glu Ile Cys Ser  Lys Phe Gly Ile Asp  Leu Ser Glu 
    1265                 1270                 1275             


Asn Ser  Glu Ile Asn Lys Pro  Glu Asn Glu Ser Ile  Arg Asn Tyr 
    1280                 1285                 1290             


Ile Ser  His Phe Tyr Ile Val  Arg Asn Pro Phe Ala  Asp Tyr Ser 
    1295                 1300                 1305             


Ile Ala  Glu Gln Ile Asp Arg  Val Ser Asn Leu Leu  Ser Tyr Ser 
    1310                 1315                 1320             


Thr Arg  Tyr Asn Asn Ser Thr  Tyr Ala Ser Val Phe  Glu Val Phe 
    1325                 1330                 1335             


Lys Lys  Asp Val Asp Leu Asp  Tyr Asp Glu Leu Lys  Lys Lys Phe 
    1340                 1345                 1350             


Lys Leu  Ile Gly Asn Thr Asp  Ile Leu Lys Arg Leu  Met Lys Pro 
    1355                 1360                 1365             


Lys Lys  Val Ser Val Leu Glu  Leu Glu Ser Tyr Asn  Ser Asn Tyr 
    1370                 1375                 1380             


Ile Lys  Asn Leu Ile Ile Glu  Leu Leu Thr Lys Val  Glu Asn Lys 
    1385                 1390                 1395             


Asp Glu  Ile Phe Ser 
    1400             


<210>  35
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  35

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Asn Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Ser Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Asn Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Glu 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Ala Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Leu Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Val 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Lys Ile Pro Tyr Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Val Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Lys 
        915                 920                 925             


Lys Tyr Glu Lys Ala Ile Arg Asn Ile Gln Gln Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Ser Leu Leu Leu 
945                 950                 955                 960 


Arg Ile Leu His Arg Leu Ile Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Arg Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Asn Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Ser Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asp  Thr Glu Lys Ile Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Glu Leu  Lys Lys Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  Asn Ala Lys Val Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Thr Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Glu Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Lys  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  36
<211>  1249
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  36

Met Lys Ile Thr Lys Ile Asp Gly Val Ser His Tyr Lys Glu Lys Glu 
1               5                   10                  15      


Lys Gly Val Leu Lys Gly Lys Asp Ile Leu Asn Gly Lys Ile Glu Lys 
            20                  25                  30          


Ile Val Lys Lys Arg Tyr Asp Ala Thr Ile Glu Ser Lys Ile Tyr Lys 
        35                  40                  45              


Glu Phe Ile Lys Leu Arg Lys Asn Arg Ile Glu Gln Asn Asn Glu Lys 
    50                  55                  60                  


Ser Ile Leu Lys Leu Ile Lys Leu Asn Ile Asp Lys Asn Glu Lys Glu 
65                  70                  75                  80  


Ile Lys Thr Leu Leu Leu Asn Lys Phe Lys Ile Lys Glu Lys Asn Lys 
                85                  90                  95      


Lys Tyr Asp Lys Tyr Met Leu Asp Glu Asn Lys Leu Asp Asn Asp Ile 
            100                 105                 110         


Lys Ile Tyr Glu Ser Val Glu Ser Leu Tyr Phe Leu Ile Lys Glu Ile 
        115                 120                 125             


Tyr Leu Gly Gln Asn Asn Lys Lys Trp Asn Ile Ser Lys Ile Asp Leu 
    130                 135                 140                 


Glu Lys Ile Met Glu Glu Asp Asn Asn Leu Ile Met Leu Gly Tyr Lys 
145                 150                 155                 160 


Leu Lys Lys Asn Ile Thr Glu Asn Asp Tyr Pro Tyr Leu Tyr Ser Asp 
                165                 170                 175     


Lys Asn Gly Gln Glu Ser Thr Ser Val Tyr Lys Leu Leu Lys Lys Leu 
            180                 185                 190         


Ile Glu Glu Asn Lys Asp Arg Asn Gln Asp Ile Arg Lys Ser Gln Glu 
        195                 200                 205             


Tyr Glu Lys Ile Arg Lys Asn Phe Glu Glu Tyr Lys Asn Arg Lys Ile 
    210                 215                 220                 


Asn Leu Leu Val Lys Ser Ile Lys Asn Asn Lys Ile Asn Ile Gln Tyr 
225                 230                 235                 240 


Ile Asn Asn Glu Ile Lys Ser His Asn Asn Ser Arg Glu Glu Asn Ile 
                245                 250                 255     


Ile Lys Phe Phe Lys Lys Met Ile Glu Glu Lys Asn Glu Pro Ile Leu 
            260                 265                 270         


Lys Asp Lys Leu Lys Leu Phe Lys Leu Glu Val Phe Phe Asp Glu Glu 
        275                 280                 285             


Phe Leu Glu Glu Ile Lys Lys Leu Leu Asp Ser Asp Asp Phe Asp Lys 
    290                 295                 300                 


Ser Tyr Asn Lys Lys Ile Ser Glu Leu Arg Gly Lys Ile Phe Asn Arg 
305                 310                 315                 320 


Ile Arg Glu Lys Ile Lys Asn Asn Lys Asn Arg Asp Glu Leu Glu Asn 
                325                 330                 335     


Ile Tyr Phe Leu Glu Leu Lys Lys Tyr Ile Glu Asn Asn Leu Ser His 
            340                 345                 350         


Lys Lys Glu Lys Asn Lys Asn Asn Asn Asn Thr Gly Glu Glu Lys Ser 
        355                 360                 365             


Lys Glu Leu Tyr Leu Lys Phe Leu Lys Lys Val Leu Phe Ile Asp Asp 
    370                 375                 380                 


Asn Asn Arg Ile Ser Ile Glu Lys Leu Lys Ser Arg Ile Asp Asp Asn 
385                 390                 395                 400 


Phe Lys Asn Leu Leu Ile Gln His Val Ile Glu Tyr Gly Lys Ile Lys 
                405                 410                 415     


Tyr Tyr Val Glu Asn Asp Asp Tyr Ile Arg Asn Ile Val Lys Asn Gly 
            420                 425                 430         


Glu Leu Lys Leu Glu Thr Lys Asp Leu Glu Tyr Ile Lys Thr Lys Glu 
        435                 440                 445             


Thr Leu Ile Arg Lys Met Val Val Leu Val Ser Phe Ala Ala Asn Ser 
    450                 455                 460                 


Tyr Tyr Asn Leu Phe Gly Ser Val Ser Glu Asp Ile Leu Gly Thr Glu 
465                 470                 475                 480 


Val Val Lys Asn Arg Arg Thr Asn Val Ile Lys Val Lys Ser Tyr Ile 
                485                 490                 495     


Phe Lys Glu Lys Met Leu Asn Tyr Phe Phe Asp Ser Glu Asp Phe Asp 
            500                 505                 510         


Ile Asn Lys Thr Ile Glu Val Leu Glu Ser Ile Ser Tyr Ser Ile Tyr 
        515                 520                 525             


Asn Ile Arg Asn Gly Val Gly His Phe Asn Lys Leu Val Leu Gly Lys 
    530                 535                 540                 


Tyr Lys Lys Lys Asp Ile Asn Thr Asn Lys Arg Val Glu Glu Asp Leu 
545                 550                 555                 560 


Asn Asn Asn Glu Glu Ile Lys Gly Tyr Phe Ile Gln Lys Arg Gly Glu 
                565                 570                 575     


Ile Glu Lys Lys Ile Lys Glu Arg Phe Leu Ser Asn Asn Leu Gln Tyr 
            580                 585                 590         


Tyr Tyr Ala Lys Glu Arg Ile Glu Asn Tyr Phe Glu Val Tyr Glu Phe 
        595                 600                 605             


Glu Ile Leu Lys Glu Lys Ile Pro Phe Ala Pro Asn Phe Lys Arg Ile 
    610                 615                 620                 


Ile Lys Lys Gly Glu Asp Leu Phe Asn Asn Lys Lys Asn Lys Lys Tyr 
625                 630                 635                 640 


Glu Tyr Phe Lys Asn Phe Asp Lys Asn Ser Ala Glu Glu Lys Lys Glu 
                645                 650                 655     


Phe Leu Lys Thr Arg Asn Phe Leu Leu Lys Glu Leu Tyr Tyr Asn Asn 
            660                 665                 670         


Phe Tyr Lys Glu Phe Leu Ser Lys Lys Glu Glu Leu Lys Lys Ile Val 
        675                 680                 685             


Ile Glu Val Lys Glu Glu Lys Lys Asn Arg Gly Asn Asn Lys Lys Ser 
    690                 695                 700                 


Gly Val Ser Phe Gln Asn Ile Asp Asp Tyr Asp Thr Lys Ile Asn Ile 
705                 710                 715                 720 


Ser Asp Tyr Ile Ala Ser Ile His Lys Lys Glu Met Glu Arg Val Glu 
                725                 730                 735     


Lys Tyr Asn Glu Glu Lys Gln Lys Asp Thr Ala Lys Tyr Ile Arg Asp 
            740                 745                 750         


Phe Val Glu Glu Ile Phe Leu Thr Gly Phe Ile Asn Tyr Leu Glu Lys 
        755                 760                 765             


Asp Glu Arg Leu His Phe Leu Lys Glu Glu Phe Ser Val Leu Cys Asn 
    770                 775                 780                 


Ser Asn Asn Asn Val Ile Asp Phe Asn Val Asn Ile Asn Glu Glu Lys 
785                 790                 795                 800 


Ile Lys Glu Phe Leu Lys Glu Asn Asp Ser Lys Thr Leu Asn Leu Tyr 
                805                 810                 815     


Leu Phe Phe Asn Met Ile Asp Ser Lys Arg Ile Ser Glu Phe Arg Asn 
            820                 825                 830         


Glu Leu Ile Lys Tyr Lys Gln Phe Thr Lys Lys Arg Leu Asp Glu Glu 
        835                 840                 845             


Lys Glu Phe Leu Gly Ile Lys Ile Glu Leu Tyr Glu Thr Leu Ile Glu 
    850                 855                 860                 


Phe Val Ile Leu Thr Arg Glu Lys Leu Asp Thr Lys Lys Ser Glu Glu 
865                 870                 875                 880 


Thr Asp Ala Trp Leu Val Asp Lys Leu Tyr Val Lys Glu Lys Asn Glu 
                885                 890                 895     


Cys Asn Glu Tyr Glu Tyr Lys Glu Tyr Glu Glu Ile Leu Lys Leu Phe 
            900                 905                 910         


Val Asp Glu Lys Ile Leu Ile Ser Lys Glu Ala Pro Tyr Tyr Ala Thr 
        915                 920                 925             


Asn Asn Lys Thr Pro Ile Ile Leu Ser Asn Phe Glu Lys Thr Arg Lys 
    930                 935                 940                 


Tyr Gly Thr Gln Asn Leu Leu Ala Lys Ile Gln Ser Ser Tyr Lys Tyr 
945                 950                 955                 960 


Asn Glu Ile Glu Lys Gln Lys Ile Glu Asn Tyr Asn Glu Lys Lys Glu 
                965                 970                 975     


Ser Glu Lys Lys Lys Lys Ser Asn Ile Glu Lys Leu Gln Asp Leu Lys 
            980                 985                 990         


Val Glu Leu His Lys Lys Trp Glu  Gln Asn Lys Ile Thr  Glu Lys Glu 
        995                 1000                 1005             


Ile Lys  Lys Tyr Asn Asp Thr  Ile Lys Glu Ile Arg  Glu Tyr Asn 
    1010                 1015                 1020             


Tyr Leu  Lys Asn Lys Glu Glu  Leu Gln Asn Val Tyr  Leu Leu His 
    1025                 1030                 1035             


Glu Ile  Leu Ser Asp Leu Leu  Ala Arg Asn Val Ala  Phe Phe Asn 
    1040                 1045                 1050             


Lys Trp  Glu Arg Asp Phe Lys  Phe Ile Val Ile Ala  Ile Lys Gln 
    1055                 1060                 1065             


Phe Leu  Arg Glu Asn Asp Lys  Glu Lys Val Asn Glu  Phe Leu Asn 
    1070                 1075                 1080             


Pro His  Lys Ser Asp Gly Ser  Arg Asp Asn Phe Ser  Val Thr Asn 
    1085                 1090                 1095             


Tyr Arg  Ser Lys Met Lys Ser  Ile Ile Asn Asn Ile  His Glu Asn 
    1100                 1105                 1110             


Phe Met  Ser Leu Leu Phe Leu  Asn Asn Asn Leu Ala  Thr Gly Gly 
    1115                 1120                 1125             


Ile Gln  Met Gly Arg Asn Asn  Asn Phe Thr Trp Gly  Asn Leu Arg 
    1130                 1135                 1140             


Asn Tyr  Ile Ala His Phe Glu  Tyr Leu His Lys Glu  Lys Asp Thr 
    1145                 1150                 1155             


Ile Ser  Phe Ile Gly Gln Ala  Asn Leu Leu Ile Lys  Leu Phe Ser 
    1160                 1165                 1170             


Tyr Asp  Lys Lys Val Gln Asn  His Ile Ile Lys Ser  Met Lys Thr 
    1175                 1180                 1185             


Leu Leu  Glu Lys Tyr Asn Ile  Glu Ile Arg Phe Glu  Ile Ser Asn 
    1190                 1195                 1200             


Asp Ser  Glu Glu Ile Phe Glu  Tyr Lys Ile Lys Tyr  Ile Asn Ser 
    1205                 1210                 1215             


Lys Lys  Gly Lys Met Leu Gly  Lys Asn Asn Glu Phe  Glu Ile Leu 
    1220                 1225                 1230             


Glu Asn  Glu Phe Val Arg Asn  Val Lys Ala Leu Leu  Glu Tyr Ser 
    1235                 1240                 1245             


Lys 
    


<210>  37
<211>  1194
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  37

Met Lys Val Thr Lys Ile Asp Gly Ile Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Phe Thr Gly His Phe Asn Ile Lys Asn Glu 
            20                  25                  30          


Met Lys Glu Arg Leu Glu Lys Leu Lys Glu Leu Lys Leu Ser Asn Tyr 
        35                  40                  45              


Ile Lys Asn Pro Glu Asn Val Lys Asn Lys Asp Lys Asn Lys Glu Lys 
    50                  55                  60                  


Glu Thr Lys Ser Arg Arg Glu Asn Leu Lys Lys Tyr Phe Ser Glu Ile 
65                  70                  75                  80  


Ile Leu Arg Lys Lys Glu Glu Lys Tyr Leu Leu Lys Lys Thr Arg Lys 
                85                  90                  95      


Phe Lys Asn Ile Thr Glu Glu Ile Asn Tyr Asp Asp Ile Lys Lys Arg 
            100                 105                 110         


Glu Asn Gln Gln Lys Ile Phe Asp Val Leu Lys Glu Leu Leu Glu Gln 
        115                 120                 125             


Arg Ile Asn Glu Asn Asp Lys Glu Glu Ile Leu Asn Phe Asp Ser Val 
    130                 135                 140                 


Lys Leu Lys Glu Ala Phe Glu Glu Asp Phe Ile Lys Lys Glu Leu Lys 
145                 150                 155                 160 


Ile Lys Ala Ile Glu Glu Ser Leu Glu Lys Asn Arg Ala Asp Tyr Arg 
                165                 170                 175     


Lys Asp Tyr Val Glu Leu Glu Asn Glu Lys Tyr Glu Asp Val Lys Gly 
            180                 185                 190         


Gln Asn Lys Arg Ser Leu Val Phe Glu Tyr Tyr Lys Asn Pro Glu Asn 
        195                 200                 205             


Arg Glu Lys Phe Lys Glu Asn Ile Lys Tyr Ala Phe Glu Asn Leu Tyr 
    210                 215                 220                 


Thr Glu Glu Asn Ile Lys Asn Leu Tyr Ser Glu Ile Lys Glu Ile Phe 
225                 230                 235                 240 


Glu Lys Val His Leu Lys Ser Lys Val Arg Tyr Phe Tyr Gln Asn Glu 
                245                 250                 255     


Ile Ile Gly Glu Ser Glu Phe Ser Glu Lys Asp Glu Glu Gly Ile Ser 
            260                 265                 270         


Ile Leu Tyr Lys Gln Ile Ile Asn Ser Val Glu Lys Lys Glu Lys Phe 
        275                 280                 285             


Ile Glu Phe Leu Gln Lys Val Lys Ile Lys Asp Leu Thr Arg Ser Gln 
    290                 295                 300                 


Ile Phe Tyr Lys Tyr Phe Leu Glu Asn Glu Glu Leu Asn Asp Glu Asn 
305                 310                 315                 320 


Ile Lys Tyr Val Phe Ser Tyr Phe Val Glu Ile Glu Val Asn Lys Leu 
                325                 330                 335     


Leu Lys Glu Asn Val Tyr Lys Thr Lys Lys Phe Asn Glu Gly Asn Lys 
            340                 345                 350         


Tyr Arg Val Lys Asn Ile Phe Asn Tyr Asp Lys Leu Lys Asn Leu Val 
        355                 360                 365             


Val Tyr Lys Leu Glu Asn Lys Leu Asn Asn Tyr Val Arg Asn Cys Gly 
    370                 375                 380                 


Lys Tyr Asn Tyr His Met Glu Asn Gly Asp Ile Ala Thr Ser Asp Ile 
385                 390                 395                 400 


Asn Met Lys Asn Arg Gln Thr Glu Ala Phe Leu Arg Ser Ile Leu Gly 
                405                 410                 415     


Val Ser Ser Phe Gly Tyr Phe Ser Leu Arg Asn Ile Leu Gly Val Asn 
            420                 425                 430         


Asp Asp Asp Phe Tyr Lys Ile Glu Lys Asp Glu Arg Lys Asn Glu Asn 
        435                 440                 445             


Phe Ile Leu Lys Lys Ala Lys Glu Asp Phe Thr Ser Lys Asn Ile Phe 
    450                 455                 460                 


Glu Lys Val Val Asp Lys Ser Phe Glu Lys Lys Gly Ile Tyr Gln Ile 
465                 470                 475                 480 


Lys Glu Asn Leu Lys Met Phe Tyr Gly Asn Ser Phe Asp Lys Val Asp 
                485                 490                 495     


Lys Asp Glu Leu Lys Lys Phe Phe Val Asn Met Leu Glu Ala Ile Thr 
            500                 505                 510         


Ser Val Arg His Arg Ile Val His Tyr Asn Ile Asn Thr Asn Ser Glu 
        515                 520                 525             


Asn Ile Phe Asp Phe Ser Asn Ile Glu Val Ser Lys Leu Leu Lys Asn 
    530                 535                 540                 


Ile Phe Glu Lys Glu Ile Asp Thr Arg Glu Leu Lys Leu Lys Ile Phe 
545                 550                 555                 560 


Arg Gln Leu Asn Ser Ala Gly Val Phe Asp Tyr Trp Glu Ser Trp Val 
                565                 570                 575     


Ile Lys Lys Tyr Leu Glu Asn Val Lys Phe Glu Phe Val Asn Lys Asn 
            580                 585                 590         


Val Pro Phe Val Pro Ser Phe Lys Lys Leu Tyr Asp Arg Ile Asp Asn 
        595                 600                 605             


Leu Lys Gly Trp Asn Ala Leu Lys Leu Gly Asn Asn Ile Asn Ile Pro 
    610                 615                 620                 


Lys Arg Lys Glu Ala Lys Asp Ser Gln Ile Tyr Leu Leu Lys Asn Ile 
625                 630                 635                 640 


Tyr Tyr Gly Glu Phe Val Glu Lys Phe Val Asn Asp Asn Lys Asn Phe 
                645                 650                 655     


Glu Lys Ile Val Lys Glu Ile Ile Glu Ile Asn Arg Gly Ala Gly Thr 
            660                 665                 670         


Asn Lys Lys Thr Gly Phe Tyr Lys Leu Glu Lys Phe Glu Thr Leu Lys 
        675                 680                 685             


Ala Asn Thr Pro Thr Lys Tyr Leu Glu Lys Leu Gln Ser Leu His Lys 
    690                 695                 700                 


Ile Ser Tyr Asp Lys Glu Lys Ile Glu Glu Asp Lys Asp Val Tyr Val 
705                 710                 715                 720 


Asp Phe Val Gln Lys Ile Phe Leu Lys Gly Phe Val Asn Tyr Leu Lys 
                725                 730                 735     


Lys Leu Asp Ser Leu Lys Ser Leu Asn Leu Leu Asn Leu Arg Lys Asp 
            740                 745                 750         


Glu Thr Ile Thr Asp Lys Lys Ser Val His Asp Glu Lys Leu Lys Leu 
        755                 760                 765             


Trp Glu Asn Ser Gly Ser Asn Leu Ser Lys Met Pro Glu Glu Ile Tyr 
    770                 775                 780                 


Glu Tyr Val Lys Lys Ile Lys Ile Ser Asn Ile Asn Tyr Asn Asp Arg 
785                 790                 795                 800 


Met Ser Ile Phe Tyr Leu Leu Leu Lys Leu Ile Asp Tyr Arg Glu Leu 
                805                 810                 815     


Thr Asn Leu Arg Gly Asn Leu Glu Lys Tyr Glu Ser Met Asn Lys Asn 
            820                 825                 830         


Lys Ile Tyr Ser Glu Glu Leu Thr Ile Ile Asn Leu Val Asn Leu Asp 
        835                 840                 845             


Asn Asn Lys Val Arg Thr Asn Phe Ser Leu Glu Ala Glu Asp Ile Gly 
    850                 855                 860                 


Lys Phe Leu Lys Ser Ser Ile Thr Ile Lys Asn Ile Ala Gln Leu Asn 
865                 870                 875                 880 


Asn Phe Ser Lys Ile Phe Ala Asp Gly Glu Asn Val Ile Lys His Arg 
                885                 890                 895     


Ser Phe Tyr Asn Ile Lys Lys Tyr Gly Ile Leu Asp Leu Leu Glu Lys 
            900                 905                 910         


Ile Val Ala Lys Ala Asp Leu Lys Ile Thr Lys Glu Glu Ile Lys Lys 
        915                 920                 925             


Tyr Glu Asn Leu Gln Asn Glu Leu Lys Arg Asn Asp Phe Tyr Lys Ile 
    930                 935                 940                 


Gln Glu Gln Ile His Arg Asn Tyr Asn Gln Lys Pro Phe Ser Ile Lys 
945                 950                 955                 960 


Lys Ile Glu Asn Lys Lys Asp Phe Glu Lys Tyr Lys Lys Val Ile Glu 
                965                 970                 975     


Lys Ile Gln Asp Tyr Thr Gln Leu Lys Asn Lys Ile Glu Phe Asn Asp 
            980                 985                 990         


Leu Asn Leu Leu Gln Ser Leu Ile  Phe Arg Ile Leu His  Arg Leu Ala 
        995                 1000                 1005             


Gly Tyr  Thr Ser Leu Trp Glu  Arg Asp Leu Gln Phe  Lys Leu Lys 
    1010                 1015                 1020             


Gly Glu  Phe Pro Glu Asp Lys  Tyr Ile Asp Glu Ile  Phe Asn Ser 
    1025                 1030                 1035             


Asp Gly  Asn Asn Asn Gln Lys  Tyr Lys His Gly Gly  Ile Ala Asp 
    1040                 1045                 1050             


Lys Tyr  Ala Asn Phe Leu Ile  Glu Lys Lys Glu Glu  Lys Ser Gly 
    1055                 1060                 1065             


Glu Ile  Leu Asn Lys Lys Gln  Arg Lys Lys Lys Ile  Lys Glu Asp 
    1070                 1075                 1080             


Leu Glu  Ile Arg Asn Tyr Ile  Ala His Phe Asn Tyr  Leu Pro Asn 
    1085                 1090                 1095             


Ala Glu  Lys Ser Ile Leu Glu  Ile Leu Glu Glu Leu  Arg Glu Leu 
    1100                 1105                 1110             


Leu Lys  His Asp Arg Lys Leu  Lys Asn Ala Val Met  Lys Ser Ile 
    1115                 1120                 1125             


Lys Asp  Ile Phe Arg Glu Tyr  Gly Phe Ile Val Glu  Phe Thr Ile 
    1130                 1135                 1140             


Ser His  Thr Lys Asn Gly Lys  Lys Ile Lys Val Cys  Ser Val Lys 
    1145                 1150                 1155             


Ser Glu  Lys Ile Lys His Leu  Lys Asn Asn Glu Leu  Ile Thr Thr 
    1160                 1165                 1170             


Arg Asn  Ser Glu Asp Leu Cys  Glu Leu Val Lys Ile  Met Leu Glu 
    1175                 1180                 1185             


His Lys  Glu Leu Gln Lys 
    1190                 


<210>  38
<211>  1186
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  38

Met Lys Val Thr Lys Ile Asp Gly Leu Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ile Glu Asp Ala Ser Gln Lys Asn Glu Thr 
            20                  25                  30          


Leu Glu Arg Leu Glu Lys Leu Lys Glu Ile Lys Leu Gly Asn Tyr Ile 
        35                  40                  45              


Lys Asn Pro Asp Lys Thr Lys Asp Lys Asp Asn Lys Lys Arg Arg Lys 
    50                  55                  60                  


Gly Leu Lys Glu Tyr Phe Ser Glu Ile Thr Leu Arg Lys Glu Asn Glu 
65                  70                  75                  80  


Lys Tyr Val Leu Leu Lys Gly Lys Lys Leu Lys Lys Ile Asn Asn Asp 
                85                  90                  95      


Ile Lys Asp Thr Asp Ile Lys Val Lys Tyr Lys Lys Glu Glu Val Phe 
            100                 105                 110         


Asp Val Leu Lys Lys Ile Leu Lys Leu Asn Leu Leu Ala Asn Asp Val 
        115                 120                 125             


Glu Glu Lys Ile Gln Phe Asp Ser Ile Lys Leu Lys Asn Val Phe Gly 
    130                 135                 140                 


Lys Asp Phe Val Lys Lys Glu Leu Gln Ile Lys Ser Ile Glu Glu Ser 
145                 150                 155                 160 


Leu Glu Lys Asn Lys Ala Asp Tyr Arg Lys Glu Phe Ile Glu Ile Glu 
                165                 170                 175     


Asn Asp Lys Tyr Gly Asn Val Lys Gly Glu Asn Lys Lys Asn Arg Ile 
            180                 185                 190         


Tyr Glu Tyr Tyr Lys Lys Ser Glu Thr His Glu Lys Phe Arg Lys Asn 
        195                 200                 205             


Ile Ile Glu Ala Phe Glu Lys Leu Tyr Lys Lys Asp Asp Ile Glu Lys 
    210                 215                 220                 


Leu Tyr Thr Gln Ile Ile Glu Ile Ser Lys Lys Met His Leu Lys Ser 
225                 230                 235                 240 


Lys Val Arg Glu Leu Tyr Lys Asn Val Ile Ile Lys Arg Ser Cys Asp 
                245                 250                 255     


Asp Phe Ser Lys Lys Asn Lys Glu Gly Ile Ser Val Leu Tyr Ser Gln 
            260                 265                 270         


Ile Met Asn Ser Val Lys Lys Asn Glu Lys Phe Val Lys Phe Val Lys 
        275                 280                 285             


Asn Ile Glu Leu Lys Asp Leu Thr Lys Ser Gln Ile Phe Tyr Lys Tyr 
    290                 295                 300                 


Phe Leu Glu Asn Glu Glu Leu Asn Asp Glu Asn Ile Lys Asn Ile Phe 
305                 310                 315                 320 


Cys Tyr Phe Val Glu Ile Glu Val Ser Asp Leu Leu Lys Gly Asn Val 
                325                 330                 335     


Tyr Lys Val Ser Lys Ile Tyr Glu Asn Lys Ile Lys Asn Ile Phe Glu 
            340                 345                 350         


Tyr Asn Lys Leu Lys Lys Leu Val Ile Asn Lys Leu Glu Asn Lys Leu 
        355                 360                 365             


Asn Asn Tyr Val Arg Asn Cys Gly Lys Tyr Asn Tyr His Met Glu Asn 
    370                 375                 380                 


Gly Asp Ile Ala Thr Ser Asp Ile Asn Met Arg Asn Arg Gln Thr Glu 
385                 390                 395                 400 


Ala Phe Leu Arg Ser Met Ile Gly Val Ser Ser Phe Gly Tyr Phe Ser 
                405                 410                 415     


Leu Arg Asn Ile Leu Gly Val Asn Asp Asp Asp Phe Tyr Glu Ile Glu 
            420                 425                 430         


Glu Asp Leu Thr Glu Glu Glu Arg Lys Asn Glu Ser Asn Val Leu Lys 
        435                 440                 445             


Lys Ala Lys Glu Asp Ile Thr Ser Lys Ser Ile Phe Glu Lys Val Val 
    450                 455                 460                 


Asp Lys Ser Phe Glu Lys Lys Gly Ile His Ser Ile Arg Glu Asn Val 
465                 470                 475                 480 


Lys Met Phe Tyr Gly Asp Ser Phe Asp Lys Ala Asn Glu Asp Glu Leu 
                485                 490                 495     


Lys Gln Phe Phe Val Asn Met Leu Asn Ala Ile Thr Ser Ile Arg His 
            500                 505                 510         


Arg Val Val His Tyr Asn Met Asn Thr Asn Ser Glu Asn Ile Phe Asn 
        515                 520                 525             


Phe Ser Asp Ile Glu Val Ser Arg Leu Leu Lys Ser Ile Phe Glu Lys 
    530                 535                 540                 


Glu Thr Asp Lys Arg Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn 
545                 550                 555                 560 


Ser Ala Gly Val Phe Asp Tyr Trp Glu Asn Trp Lys Ile Lys Lys Tyr 
                565                 570                 575     


Leu Glu Asn Met Lys Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val 
            580                 585                 590         


Pro Ser Phe Thr Lys Leu Tyr Asn Arg Ile Asp Asn Leu Lys Gly Ser 
        595                 600                 605             


Asn Ala Leu Asn Leu Gly Tyr Ile Asn Ile Pro Lys Arg Lys Glu Ala 
    610                 615                 620                 


Arg Asp Ser Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Lys Phe 
625                 630                 635                 640 


Val Glu Glu Phe Ile Lys Asn Asn Asp Asn Phe Glu Lys Ile Phe Arg 
                645                 650                 655     


Glu Ile Ile Glu Ile Asn Lys Asn Ala Gly Thr Asn Lys Gln Thr Asn 
            660                 665                 670         


Phe Tyr Lys Leu Glu Lys Phe Glu Lys Leu Lys Ala Asn Thr Pro Thr 
        675                 680                 685             


Glu Tyr Leu Glu Lys Leu Gln Ser Leu His Lys Ile Asn Tyr Asn Arg 
    690                 695                 700                 


Glu Lys Ile Glu Glu Asp Lys Asp Ile Tyr Val Asp Phe Val Gln Lys 
705                 710                 715                 720 


Ile Phe Leu Lys Gly Phe Ile Ser Tyr Leu Gln Lys Ser Asn Ser Leu 
                725                 730                 735     


Lys Pro Leu Asn Leu Leu Asn Leu Lys Lys Asp Glu Val Ile Asn Ser 
            740                 745                 750         


Glu Lys Ser Phe Tyr Asp Glu Lys Leu Lys Gln Trp Glu Asn Asn Gly 
        755                 760                 765             


Ser Asn Leu Ser Glu Met Pro Lys Glu Ile Tyr Lys Tyr Ile Lys Glu 
    770                 775                 780                 


Ile Lys Ile Asn Lys Thr Asn Tyr Ser Asp Arg Met Ser Ile Phe Tyr 
785                 790                 795                 800 


Leu Leu Leu Lys Leu Ile Asp His Lys Glu Leu Thr Asn Leu Arg Gly 
                805                 810                 815     


Asn Leu Glu Lys Tyr Glu Ser Met Asn Lys Asn Lys Ile Tyr Ser Glu 
            820                 825                 830         


Glu Leu Asn Ile Val Asn Leu Val Ser Leu Asp Asn Asn Lys Val Arg 
        835                 840                 845             


Thr Asn Phe Ser Val Glu Ala Glu Asp Ile Gly Lys Phe Leu Lys Thr 
    850                 855                 860                 


Glu Thr Ser Ile Lys Asn Ile Asn Gln Leu Asn Asn Phe Ser Gly Ile 
865                 870                 875                 880 


Phe Ala Asp Gly Glu Asn Val Ile Lys His Arg Ser Phe Tyr Asn Ile 
                885                 890                 895     


Lys Lys Tyr Gly Ile Leu Asp Leu Leu Glu Lys Ile Val Ala Lys Ala 
            900                 905                 910         


Asp Leu Lys Ile Ala Lys Glu Glu Ile Lys Lys Tyr Glu Asn Leu Gln 
        915                 920                 925             


Lys Glu Leu Glu Lys Asn Asp Phe Tyr Lys Ile Gln Glu Lys Ile His 
    930                 935                 940                 


Arg Lys Tyr Asn Gln Lys Pro Asn Leu Ile Ser Arg Thr Glu Asn Lys 
945                 950                 955                 960 


Lys Asp Phe Asn Asp Tyr Lys Lys Ala Ile Glu Asn Ile Gln Asn Tyr 
                965                 970                 975     


Thr Gln Leu Lys Asn Lys Ile Glu Phe Asn Asp Leu Asn Leu Leu Gln 
            980                 985                 990         


Gly Leu Leu Phe Arg Ile Leu His  Arg Leu Thr Gly Tyr  Thr Ser Leu 
        995                 1000                 1005             


Trp Glu  Arg Asp Leu Gln Phe  Lys Leu Lys Gly Glu  Phe Pro Glu 
    1010                 1015                 1020             


Asp Lys  Tyr Ile Asp Glu Ile  Phe Asn Ser Asp Arg  Asn Asn Asn 
    1025                 1030                 1035             


Gln Lys  Tyr Lys Ser Gly Gly  Ile Ala Tyr Lys Tyr  Val Asp Phe 
    1040                 1045                 1050             


Leu Ile  Glu Lys Glu Glu Gly  Lys Arg Ala Gly Lys  Asn Lys Val 
    1055                 1060                 1065             


Lys Lys  Arg Ser Glu Arg Glu  Arg Ser Phe Ile Ile  Arg Asn Tyr 
    1070                 1075                 1080             


Ile Ala  His Phe Asn Tyr Ile  Pro Asp Ala Glu Lys  Ser Ile Leu 
    1085                 1090                 1095             


Glu Ile  Leu Glu Glu Leu Arg  Glu Leu Leu Lys Tyr  Asp Arg Lys 
    1100                 1105                 1110             


Leu Lys  Asn Ala Val Met Lys  Ser Ile Lys Asp Ile  Phe Lys Glu 
    1115                 1120                 1125             


Tyr Gly  Phe Ile Ile Glu Phe  Gly Ile Ser His Glu  Ser Asn Ser 
    1130                 1135                 1140             


Lys Lys  Ile Lys Val Leu Asn  Val Glu Ser Glu Lys  Ile Lys His 
    1145                 1150                 1155             


Leu Lys  Asn Asn Gly Leu Val  Thr Thr Arg Asn Ser  Lys Asp Leu 
    1160                 1165                 1170             


Cys Lys  Leu Val Lys Val Met  Leu Glu Tyr Lys Lys  Ser 
    1175                 1180                 1185     


<210>  39
<211>  1149
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  39

Met Lys Ile Thr Lys Ile Asp Gly Ile Ser His Lys Lys Tyr Lys Glu 
1               5                   10                  15      


Lys Gly Lys Leu Ile Lys Ser Asn Glu Ile Glu Lys Asp Val Thr Glu 
            20                  25                  30          


Glu Arg Phe Tyr Asp Ile Lys Thr Lys Thr Thr Glu Leu Phe Leu Lys 
        35                  40                  45              


Thr Leu Asp Phe Tyr Val Lys Asn Tyr Glu Gln Cys Glu Glu Gln Asn 
    50                  55                  60                  


Lys Glu Arg Arg Glu Lys Ala Lys Asn Tyr Phe Ser Lys Val Lys Leu 
65                  70                  75                  80  


Ile Ile Glu Asn Arg Lys Ile Thr Ile Phe Asn Glu Asn Thr Glu Lys 
                85                  90                  95      


Ile Glu Ile Glu Gly Phe Asn Glu Tyr Asp Val Arg Asp Glu Lys Tyr 
            100                 105                 110         


Phe Asn Val Leu Asn Lys Ile Leu Lys Glu Glu Asn Cys Thr Glu Glu 
        115                 120                 125             


Asp Leu Glu Val Phe Glu Asn Asp Leu Gln Lys Lys Leu Asn Gln Ile 
    130                 135                 140                 


Gln Ser Ile Lys Asn Ser Leu Glu Glu Asn Lys Ala His Phe Lys Lys 
145                 150                 155                 160 


Glu Ser Val Asn Asn Thr Ala Asp Arg Val Lys Gly Asn Asn Lys Lys 
                165                 170                 175     


Ser Leu Phe Tyr Glu Tyr Tyr Arg Ile Ser Ser Lys His Gln Glu Tyr 
            180                 185                 190         


Ala Asn Asn Ile Phe Glu Ala Phe Asp Lys Leu Tyr Ser Asn Ser His 
        195                 200                 205             


Glu Ala Met Asn Asn Leu Phe Ser Glu Ile Thr Lys Asp Ser Lys Asp 
    210                 215                 220                 


Arg Asn Ile Arg Lys Ile Arg Glu Ala Tyr His Glu Ile Leu Asn Lys 
225                 230                 235                 240 


Asn Lys Thr Glu Phe Gly Glu Glu Leu Tyr Lys Lys Ile Gln Asp Asn 
                245                 250                 255     


Arg Asn Asn Phe Asp Lys Leu Leu Glu Ile Glu Pro Glu Ile Lys Glu 
            260                 265                 270         


Leu Thr Lys Ser Gln Ile Phe Tyr Lys Tyr Tyr Ile Asp Lys Val Asn 
        275                 280                 285             


Leu Asp Glu Thr Ser Ile Lys His Cys Phe Cys His Leu Val Glu Ile 
    290                 295                 300                 


Glu Val Asn Gln Leu Leu Lys Asn Tyr Val Tyr Ser Lys Arg Asn Ile 
305                 310                 315                 320 


Asn Lys Glu Lys Leu Glu Asn Ile Phe Glu Tyr Cys Lys Leu Arg Asn 
                325                 330                 335     


Leu Val Lys Asn Lys Leu Val Asn Lys Leu Asn Asn Tyr Ile Arg Asn 
            340                 345                 350         


Cys Gly Lys Tyr Asn Ala Tyr Ile Ser Asn Asn Asp Val Val Val Asn 
        355                 360                 365             


Ser Glu Lys Ile Ser Glu Ile Arg Thr Lys Glu Ala Phe Leu Arg Ser 
    370                 375                 380                 


Ile Ile Gly Val Ser Ser Ser Ala Tyr Phe Ser Leu Arg Asn Ile Leu 
385                 390                 395                 400 


Asn Thr Asp Asn Thr Gln Asp Ile Thr Asn Lys Val Asp Lys Glu Val 
                405                 410                 415     


Asp Lys Leu Tyr Gln Glu Asn Lys Lys Ile Glu Leu Glu Glu Ile Leu 
            420                 425                 430         


Lys Leu Phe Phe Gly Asn Tyr Phe Asp Ile Asn Asn Gln Gln Glu Ile 
        435                 440                 445             


Lys Val Phe Leu Met Asn Ile Asp Lys Ile Ile Ser Ser Ile Arg His 
    450                 455                 460                 


Glu Ile Ile His Phe Lys Met Glu Thr Asn Ala Gln Asn Ile Phe Asp 
465                 470                 475                 480 


Phe Asn Asn Val Asn Leu Gly Asn Thr Ala Lys Asn Ile Phe Ser Asn 
                485                 490                 495     


Glu Ile Asn Glu Glu Lys Ile Lys Phe Lys Ile Phe Lys Gln Leu Asn 
            500                 505                 510         


Ser Ala Asn Val Phe Asp Tyr Leu Ser Asn Lys Asp Ile Thr Glu Tyr 
        515                 520                 525             


Met Asp Lys Val Val Phe Ser Phe Thr Asn Arg Asn Val Ser Phe Val 
    530                 535                 540                 


Pro Ser Phe Thr Lys Ile Tyr Asn Arg Val Gln Asp Leu Ala Asn Ser 
545                 550                 555                 560 


Leu Glu Ile Lys Glu Trp Lys Ile Pro Asp Glu Ser Glu Gly Lys Asp 
                565                 570                 575     


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Lys Phe Leu Asp 
            580                 585                 590         


Lys Phe Leu Asn Glu Glu Asn Gly Ile Phe Ile Ser Ile Lys Asp Lys 
        595                 600                 605             


Ile Ile Glu Leu Asn Arg Asn Gln Asn Lys Arg Thr Gly Phe Tyr Lys 
    610                 615                 620                 


Leu Glu Lys Phe Glu Lys Ile Glu Glu Thr Asn Pro Lys Lys Tyr Leu 
625                 630                 635                 640 


Glu Ile Ile Gln Ser Leu Tyr Met Ile Asn Ile Glu Glu Ile Asp Ser 
                645                 650                 655     


Glu Gly Lys Asn Ile Phe Leu Asp Phe Ile Gln Lys Ile Phe Leu Lys 
            660                 665                 670         


Gly Phe Phe Glu Phe Ile Lys Asn Asp Tyr Asn Tyr Leu Leu Glu Leu 
        675                 680                 685             


Lys Lys Val Gln Asp Lys Lys Asn Ile Phe Asp Ser Lys Met Ser Glu 
    690                 695                 700                 


Tyr Ile Ala Gly Glu Lys Thr Leu Glu Asp Met Glu Glu Ile Asn Glu 
705                 710                 715                 720 


Ile Ile Gln Asp Ile Lys Ile Thr Glu Ile Asp Lys Ile Leu Asn Gln 
                725                 730                 735     


Thr Asp Lys Ile Asn Cys Phe Tyr Leu Leu Leu Lys Leu Leu Asn Tyr 
            740                 745                 750         


Lys Glu Ile Thr Glu Leu Lys Gly Asn Leu Glu Lys Tyr Gln Ile Leu 
        755                 760                 765             


Ser Lys Thr Asn Val Tyr Glu Lys Glu Leu Met Leu Leu Asn Ile Val 
    770                 775                 780                 


Asn Leu Asp Asn Asn Lys Val Lys Ile Glu Asn Phe Lys Ile Ser Ala 
785                 790                 795                 800 


Glu Glu Ile Gly Lys Phe Ile Glu Lys Ile Asn Ile Glu Glu Ile Asn 
                805                 810                 815     


Lys Lys Ile Lys Thr Phe Gly Glu Leu Arg Asn Phe Glu Lys Gly Glu 
            820                 825                 830         


Asn Thr Gly Glu Tyr Tyr Asn Ile Tyr Ser Asp Asp Lys Asn Ile Lys 
        835                 840                 845             


Asn Ile Arg Asn Leu Tyr Asn Ile Lys Lys Tyr Gly Met Leu Asp Leu 
    850                 855                 860                 


Leu Glu Lys Ile Ser Glu Lys Thr Asn Tyr Cys Ile Lys Lys Lys Asp 
865                 870                 875                 880 


Leu Lys Glu Tyr Ser Lys Leu Arg Lys Gln Leu Glu Asp Lys Lys Lys 
                885                 890                 895     


Glu Asn Glu Lys Ile Glu Asp Glu Lys Thr Asn Phe Tyr Lys Ile Gln 
            900                 905                 910         


Glu Tyr Leu His Ser Lys Tyr Gln Gln Glu Pro Lys Lys Ile Leu Trp 
        915                 920                 925             


Lys Lys Asn Lys Asn Asp Tyr Glu Lys Tyr Lys Lys Ser Ile Glu Asn 
    930                 935                 940                 


Ile Glu Lys Tyr Val His Leu Lys Asn Lys Ile Glu Phe Asn Glu Leu 
945                 950                 955                 960 


Asn Leu Leu Gln Ser Leu Leu Leu Lys Ile Leu His Arg Leu Ala Gly 
                965                 970                 975     


Phe Thr Ser Ile Trp Glu Arg Asp Leu Arg Phe Arg Leu Thr Gly Glu 
            980                 985                 990         


Phe Pro Asp Glu Leu Asp Val Glu  Asp Ile Phe Asn His  Arg Lys Arg 
        995                 1000                 1005             


Tyr Lys  Gly Thr Gly Lys Gly  Ile Cys Lys Lys Tyr  Asp Arg Phe 
    1010                 1015                 1020             


Ile Asn  Thr His Thr Glu Tyr  Lys Asn Asn Asn Lys  Met Lys Asn 
    1025                 1030                 1035             


Val Lys  Phe Val Asp Asp Asn  Pro Val Arg Asn Tyr  Ile Ala His 
    1040                 1045                 1050             


Phe Asn  Tyr Leu Pro Thr Pro  Lys Tyr Ser Ile Leu  Lys Met Met 
    1055                 1060                 1065             


Glu Lys  Leu Arg Lys Leu Leu  Asp Tyr Asp Arg Lys  Leu Lys Asn 
    1070                 1075                 1080             


Ala Val  Met Lys Ser Ile Lys  Asp Ile Leu Glu Glu  Tyr Gly Phe 
    1085                 1090                 1095             


Lys Ala  Glu Phe Ile Ile Asn  Ser Asp Lys Glu Ile  Ile Leu Asn 
    1100                 1105                 1110             


Ser Val  Lys Ser Val Glu Ile  Ile His Leu Gly Lys  Glu Asp Leu 
    1115                 1120                 1125             


Lys Ser  His Arg Asn Ser Glu  Asp Leu Cys Lys Leu  Val Lys Ala 
    1130                 1135                 1140             


Met Leu  Glu Tyr Ser Glu 
    1145                 


<210>  40
<211>  1208
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  40

Met Lys Val Thr Lys Ile Asp Gly Ile Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Arg Phe Thr Gly Asn Phe Asn Ile Lys Asn Glu 
            20                  25                  30          


Met Lys Glu Arg Leu Glu Lys Leu Lys Glu Leu Lys Leu Ser Asn Tyr 
        35                  40                  45              


Ile Lys Asn Pro Glu Asn Val Lys Asn Lys Asp Lys Asn Lys Glu Glu 
    50                  55                  60                  


Glu Thr Lys Ser Arg Arg Lys Asn Leu Lys Lys Tyr Phe Ser Glu Ile 
65                  70                  75                  80  


Ile Leu Arg Lys Lys Glu Glu Lys Tyr Leu Leu Lys Lys Thr Arg Lys 
                85                  90                  95      


Phe Lys Asp Ile Thr Glu Glu Ile Asn Tyr Asp Asp Ile Lys Lys Gly 
            100                 105                 110         


Glu Asn Gln Gln Lys Ile Phe Asp Val Leu Lys Glu Leu Leu Glu Gln 
        115                 120                 125             


Arg Ile Asn Glu Asn Asp Lys Glu Glu Ile Leu Asn Phe Asp Ser Val 
    130                 135                 140                 


Lys Leu Lys Glu Ala Phe Gly Glu Asp Phe Ile Lys Lys Glu Ser Lys 
145                 150                 155                 160 


Ile Lys Ala Ile Glu Glu Ser Leu Glu Lys Asn Arg Ala Asp Tyr Arg 
                165                 170                 175     


Lys Asp Tyr Val Glu Leu Glu Asn Glu Lys Tyr Glu Asp Val Lys Gly 
            180                 185                 190         


Gln Asn Lys Arg Ser Leu Val Phe Glu Tyr Tyr Lys Asn Pro Glu Asn 
        195                 200                 205             


Arg Glu Lys Phe Lys Glu Asn Ile Lys Tyr Ala Phe Glu Asn Leu Tyr 
    210                 215                 220                 


Thr Glu Glu Asn Ile Lys Asn Leu Tyr Ser Glu Ile Glu Glu Ile Phe 
225                 230                 235                 240 


Glu Lys Val His Leu Lys Ser Lys Val Arg Asp Phe Tyr Gln Asn Gly 
                245                 250                 255     


Ile Ile Gly Glu Ser Glu Phe Ser Glu Lys Asp Glu Glu Gly Ile Ser 
            260                 265                 270         


Ile Leu Tyr Lys Gln Ile Ile Asn Ser Val Glu Lys Lys Glu Lys Phe 
        275                 280                 285             


Val Glu Phe Leu Gln Lys Val Lys Ile Lys Asp Leu Thr Arg Ser Gln 
    290                 295                 300                 


Ile Phe Tyr Lys Tyr Phe Leu Glu Asn Glu Lys Leu Asn Asn Glu Asn 
305                 310                 315                 320 


Ile Lys Tyr Val Phe Ser Tyr Phe Val Glu Ile Glu Val Asn Lys Leu 
                325                 330                 335     


Leu Lys Glu Asn Val Tyr Lys Thr Lys Lys Phe Asn Glu Gly Asn Lys 
            340                 345                 350         


Tyr Arg Val Lys Asn Ile Phe Asn Tyr Asp Lys Leu Lys Asn Leu Val 
        355                 360                 365             


Val Tyr Lys Leu Glu Asn Lys Leu Asn Asn Tyr Ile Arg Asn Cys Gly 
    370                 375                 380                 


Lys Tyr Asn Tyr His Ile Glu Asn Gly Cys Val Ala Thr Ser Asp Thr 
385                 390                 395                 400 


Asn Met Lys Asn Arg Gln Ile Glu Ala Phe Leu Arg Ser Ile Leu Gly 
                405                 410                 415     


Val Ser Ser Phe Gly Tyr Phe Ser Leu Arg Asn Ile Leu Gly Val Asn 
            420                 425                 430         


Asp Asn Asp Phe Tyr Glu Met Glu Glu Glu Leu Thr Glu Asp Glu Arg 
        435                 440                 445             


Lys Asn Glu Asn Ser Ile Leu Lys Glu Asp Ser Ile Leu Lys Glu Ala 
    450                 455                 460                 


Lys Lys Asp Ile Thr Ser Lys Asp Asp Ile Phe Lys Lys Val Val Asp 
465                 470                 475                 480 


Lys Ser Phe Glu Lys Lys Gly Ile Tyr Gln Ile Lys Glu Asn Leu Lys 
                485                 490                 495     


Met Phe Tyr Gly Asn Ser Phe Asp Lys Val Asp Lys Asp Glu Leu Lys 
            500                 505                 510         


Lys Phe Phe Val Asn Met Leu Glu Ala Ile Thr Ser Val Arg His Arg 
        515                 520                 525             


Ile Val His Tyr Asn Ile Asn Thr Asn Ser Glu Asn Ile Phe Asp Phe 
    530                 535                 540                 


Ser Asn Ile Glu Val Ser Lys Leu Leu Lys Asn Ile Phe Glu Lys Glu 
545                 550                 555                 560 


Ile Asp Thr Arg Glu Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser 
                565                 570                 575     


Ala Gly Val Phe Asp Tyr Trp Glu Ser Trp Val Ile Lys Lys Tyr Leu 
            580                 585                 590         


Glu Asn Val Lys Phe Glu Phe Val Asn Lys Asn Val Pro Phe Val Pro 
        595                 600                 605             


Ser Phe Lys Lys Leu Tyr Asp Arg Ile Asp Asp Leu Lys Gly Trp Asn 
    610                 615                 620                 


Ala Leu Lys Leu Gly Asn Asn Ile Asn Ile Pro Lys Arg Lys Glu Ala 
625                 630                 635                 640 


Lys Asp Ser Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe 
                645                 650                 655     


Val Glu Lys Phe Val Asn Asp Asn Lys Asn Phe Glu Lys Ile Val Glu 
            660                 665                 670         


Glu Ile Ile Glu Ile Asn Arg Gly Ala Gly Thr Asn Lys Arg Thr Gly 
        675                 680                 685             


Phe Tyr Lys Leu Glu Lys Phe Glu Thr Leu Lys Ala Asn Thr Pro Thr 
    690                 695                 700                 


Glu Tyr Leu Glu Lys Leu Gln Ser Leu His Lys Ile Ser Tyr Asp Lys 
705                 710                 715                 720 


Glu Lys Ile Glu Glu Asp Lys Asp Ile Tyr Val Asp Phe Val Gln Lys 
                725                 730                 735     


Ile Phe Leu Lys Gly Phe Val Asn Tyr Leu Lys Lys Leu Asp Ser Leu 
            740                 745                 750         


Lys Ser Leu Asn Leu Leu Asn Leu Arg Lys Asp Glu Thr Ile Thr Asp 
        755                 760                 765             


Lys Lys Ser Val His Asp Glu Lys Leu Lys Leu Trp Glu Asn Ser Gly 
    770                 775                 780                 


Ser Asn Leu Phe Lys Met Pro Glu Glu Ile Tyr Glu Tyr Val Lys Lys 
785                 790                 795                 800 


Ile Lys Ile Ser Asn Ile Asn Tyr Asn Asp Arg Met Ser Ile Phe Tyr 
                805                 810                 815     


Leu Leu Leu Lys Leu Ile Asp Tyr Arg Glu Leu Thr Asn Leu Arg Gly 
            820                 825                 830         


Asn Leu Glu Lys Tyr Glu Ser Met Asn Lys Asn Lys Ile Tyr Ser Glu 
        835                 840                 845             


Glu Leu Thr Ile Ile Asn Leu Val Asn Leu Asp Asn Asn Lys Val Arg 
    850                 855                 860                 


Thr Asn Phe Ser Leu Glu Ala Glu Asp Ile Gly Lys Phe Leu Lys Ser 
865                 870                 875                 880 


Ser Ile Pro Ile Lys Asn Ile Ala Gln Leu Asn Asn Phe Ser Lys Ile 
                885                 890                 895     


Phe Ala Asp Gly Glu Asn Val Ile Lys His Lys Ser Phe Tyr Asn Ile 
            900                 905                 910         


Lys Lys Tyr Gly Ile Leu Asp Leu Leu Glu Lys Ile Val Ala Lys Ala 
        915                 920                 925             


Asp Leu Lys Ile Ala Lys Glu Glu Ile Lys Lys Tyr Glu Asn Leu Gln 
    930                 935                 940                 


Lys Glu Leu Glu Lys Asn Asp Phe Tyr Lys Ile Gln Glu Gln Ile His 
945                 950                 955                 960 


Arg Asn Tyr Asn Gln Asn Pro Phe Ser Ile Lys Lys Ile Glu Asn Lys 
                965                 970                 975     


Lys Asp Phe Glu Lys Tyr Lys Lys Val Ile Glu Lys Ile Gln Asp Tyr 
            980                 985                 990         


Thr Gln Leu Lys Asn Lys Ile Glu  Phe Asn Asp Leu Asn  Leu Leu Gln 
        995                 1000                 1005             


Ser Leu  Ile Phe Arg Ile Leu  His Arg Leu Ala Gly  Tyr Thr Ser 
    1010                 1015                 1020             


Leu Trp  Glu Arg Asp Leu Gln  Phe Lys Leu Lys Gly  Glu Phe Pro 
    1025                 1030                 1035             


Glu Asp  Lys Tyr Ile Asp Glu  Ile Phe Ser Phe Asp  Asn Asn Lys 
    1040                 1045                 1050             


Asn Glu  Lys Tyr Lys Asp Gly  Ser Ile Val Phe Lys  Tyr Ala Asp 
    1055                 1060                 1065             


Phe Leu  Ile Glu Lys Glu Glu  Glu Lys Leu Gly Glu  Val Leu Lys 
    1070                 1075                 1080             


Lys Asn  Lys Arg Asn Lys Arg  Lys Lys Glu Ile Ile  Glu Lys Asp 
    1085                 1090                 1095             


Gly Leu  Glu Ile Arg Asn Tyr  Ile Ala His Phe Asn  Tyr Leu Pro 
    1100                 1105                 1110             


Asn Ala  Glu Lys Ser Ile Leu  Glu Ile Leu Glu Glu  Leu Arg Glu 
    1115                 1120                 1125             


Leu Leu  Lys His Asp Arg Lys  Leu Lys Asn Ala Val  Met Lys Ser 
    1130                 1135                 1140             


Ile Lys  Asp Ile Phe Lys Glu  Tyr Gly Phe Ile Val  Glu Phe Thr 
    1145                 1150                 1155             


Ile Ser  His Thr Lys Asn Gly  Lys Lys Ile Lys Val  Cys Ser Val 
    1160                 1165                 1170             


Lys Ser  Glu Lys Ile Lys His  Leu Lys Asn Asn Glu  Leu Ile Thr 
    1175                 1180                 1185             


Thr Arg  Asn Ser Lys Asp Leu  Cys Glu Leu Val Lys  Ile Met Leu 
    1190                 1195                 1200             


Glu Tyr  Lys Glu Ala 
    1205             


<210>  41
<211>  1403
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  41

Met Gly Asn Leu Phe Gly Tyr Lys Lys Trp Tyr Lys Val Asp Lys Ile 
1               5                   10                  15      


Ile Lys Asp Lys Lys Gly Lys Lys Ser Thr Ile Lys Gln Glu Val Arg 
            20                  25                  30          


Ile Lys Arg Asn Tyr Leu Thr Asn Arg Tyr Ile Leu Asn Thr Asn Asn 
        35                  40                  45              


Lys Asp Lys Asn Asn Ile Asn Asn Glu Asp Phe Val Asp Gln Phe Ile 
    50                  55                  60                  


Glu Tyr Lys Thr Lys Asn Asp Ile Phe Glu Lys Phe Thr Arg Lys Phe 
65                  70                  75                  80  


His Met Gly Asn Ile Leu Phe Lys Leu Lys Gly Asn Lys Arg Ser Ile 
                85                  90                  95      


Glu Asp Ser Asn Asp Phe Leu Lys Thr Glu Glu Val Val Leu Asp Lys 
            100                 105                 110         


Glu Ile Tyr Gly Gln Ser Glu Lys Leu Arg Asn Glu Lys Gly Ile Thr 
        115                 120                 125             


Lys Gln Gly Ile Leu Lys Glu Ile Ile Asp Lys Gly Ile Asn Glu Ser 
    130                 135                 140                 


Asn Asp Ser Ile Leu Ile Lys Thr Lys Phe Gly Lys Glu Ile Lys Ile 
145                 150                 155                 160 


Asn Phe Thr Asp Glu Ser Lys Lys Asn Lys Asn Glu Tyr Gln Ile Thr 
                165                 170                 175     


Leu Lys Val Ile Pro Glu Asn Glu Leu Lys Ile Lys Arg Glu Val Tyr 
            180                 185                 190         


Asp Val Phe Lys Met Ile Asn Met Asp Leu Tyr Gln Ile Ile Lys Glu 
        195                 200                 205             


Ile Ile Glu Asn Glu Val Gln Lys Val Phe Lys Asn Arg Tyr Tyr Glu 
    210                 215                 220                 


Glu Tyr Leu Arg Glu Lys Leu Leu Glu Asp Asn Gln Ile Asn Val Ile 
225                 230                 235                 240 


Leu Thr Asn Phe Met Lys Ile Arg Glu Lys Thr Lys Ser Asn Ser Glu 
                245                 250                 255     


Ile Met Gly Phe Val Lys Phe Tyr Leu Asn Val Gly Gly Asp Lys Lys 
            260                 265                 270         


Lys Ser Glu Asn Lys Lys Met Phe Val Glu Lys Ile Leu Asn Ile Asn 
        275                 280                 285             


Val Asp Leu Thr Glu Glu Asp Ile Val Asp Phe Ile Val Lys Glu Leu 
    290                 295                 300                 


Lys Phe Tyr Gly Ile Ile Lys Arg Ile Glu Lys Leu Gln Glu Lys Lys 
305                 310                 315                 320 


Ala Asp Arg Thr Asp Lys Asp Ile Lys Lys Thr Tyr Ile Asn Thr Tyr 
                325                 330                 335     


Val Ser Leu Asp Lys His Glu Lys Phe Lys Lys Tyr Asn Arg Asn Lys 
            340                 345                 350         


Lys Asp Thr Ile Val Lys Ser Phe Ile Lys Asp Ile Lys Asp Asn Thr 
        355                 360                 365             


Met Lys Gln Lys Ile Asn Gln Ile Leu Arg Lys Phe Lys Ile Glu Glu 
    370                 375                 380                 


Leu Ile Asn Lys Leu Arg Ile Glu Asn Lys Asn Phe Asp Thr Glu Ile 
385                 390                 395                 400 


Phe Arg Ile Phe Lys Glu His Tyr Gln Glu Ile Phe Asn Ser Glu Lys 
                405                 410                 415     


Phe Glu Glu Lys Ser Asp Glu Glu Lys Glu Leu Tyr Lys Ile Ile Tyr 
            420                 425                 430         


Arg Tyr Leu Lys Gly Arg Ile Glu Lys Ile Leu Ile Asn Glu Gln Lys 
        435                 440                 445             


Val Arg Leu Lys Lys Met Glu Lys Ile Glu Val Glu Lys Ile Leu Asn 
    450                 455                 460                 


Glu Ser Ile Leu Ser Glu Lys Ile Leu Lys Arg Val Lys Gln Tyr Thr 
465                 470                 475                 480 


Leu Glu His Val Met Tyr Leu Gly Lys Leu Val His Asn Asp Ile Asp 
                485                 490                 495     


Arg Ser Ile Val Asn Thr Asn Asp Phe Ser Arg Leu His Ala Lys Glu 
            500                 505                 510         


Glu Leu Asp Leu Glu Leu Ile Thr Phe Phe Ala Ser Thr Asn Met Glu 
        515                 520                 525             


Leu Asn Lys Ile Phe Ser Arg Lys Asp Glu Tyr Glu Glu Asn Thr Asp 
    530                 535                 540                 


Phe Phe Gly Glu Gly Ala Phe Ser Asn Lys Lys Arg Glu Lys Ile Thr 
545                 550                 555                 560 


Leu Asn Lys Lys Ser Leu Asn Ser Lys Ile Lys Met Ile Arg Glu Leu 
                565                 570                 575     


Asp Phe Ile Asp Asn Lys Asn Glu Ile Ile Arg Glu Asn Phe Phe Glu 
            580                 585                 590         


Lys Phe Ile Lys Ile Gly Ala Asn Glu Arg Asn Arg Ile Leu His Ala 
        595                 600                 605             


Ser Asn Lys Arg Arg Val Pro Gln Gly Thr Gln Asp Asp Tyr Asn Lys 
    610                 615                 620                 


Val Ile Asn Ile Ile Gln Asn Leu Lys Ile Ser Asp Glu Glu Val Ser 
625                 630                 635                 640 


Lys Ala Leu Asn Leu Asp Val Val Phe Lys Asp Lys Lys Asn Ile Ile 
                645                 650                 655     


Thr Lys Ile Asn Asp Ile Glu Ile Ser Glu Glu Asn Asn Ser Ile Ile 
            660                 665                 670         


Lys Tyr Leu Pro Ser Phe Ser Lys Val Leu Pro Glu Ile Leu Asn Leu 
        675                 680                 685             


Tyr Lys Asn Glu Asn Lys Asn Asn Pro Phe Asp Thr Ile Glu Thr Glu 
    690                 695                 700                 


Lys Ile Ile Gln Asn Ala Leu Ile Tyr Val Asn Lys Glu Leu Tyr Lys 
705                 710                 715                 720 


Lys Leu Ile Ser Glu Lys Asn Leu Glu Glu Asn Glu Ser Lys Asn Lys 
                725                 730                 735     


Phe Leu Lys Glu Leu Lys Lys Asn Leu Ser Gly Thr Asp Glu Thr Asp 
            740                 745                 750         


Glu Asn Ile Ile Glu Asn Tyr Tyr Lys Asn Ala Gln Ile Ser Ala Ser 
        755                 760                 765             


Lys Gly Asn Asn Lys Ala Ile Lys Lys Tyr Gln Lys Lys Val Ile Glu 
    770                 775                 780                 


Cys Tyr Val Gly Tyr Leu Arg Lys Asn Tyr Glu Glu Leu Phe Asp Phe 
785                 790                 795                 800 


Ser Asp Phe Lys Met Asn Ile Gln Glu Ile Lys Lys Gln Ile Lys Asp 
                805                 810                 815     


Ile Ser Asp Asn Lys Thr Tyr Glu Arg Ile Thr Ile Lys Thr Ser Asp 
            820                 825                 830         


Lys Ser Ile Val Ile Asn Asp Asp Phe Glu Tyr Ile Ile Ser Ile Phe 
        835                 840                 845             


Ala Leu Leu Asn Ser Asn Ala Val Ile Asn Lys Ile Arg Asn Arg Phe 
    850                 855                 860                 


Phe Ala Thr Ser Val Trp Leu Asn Thr Ser Glu Tyr Gln Asn Ile Ile 
865                 870                 875                 880 


Asp Val Leu Asp Glu Ile Met Gln Leu Asn Thr Leu Arg Asn Glu Cys 
                885                 890                 895     


Ile Thr Glu Asn Trp Asn Leu Asn Leu Glu Glu Phe Ile Gln Lys Met 
            900                 905                 910         


Lys Asp Ile Glu Lys Glu Phe Glu Asp Phe Lys Ile Gln Thr Lys Lys 
        915                 920                 925             


Asp Ile Phe Asn Thr Asn Tyr Glu Gly Ile Lys Asn Ser Val Leu Asn 
    930                 935                 940                 


Lys Phe Ile Glu Phe Ser Asp Val Gln Lys Ile Leu Glu Gly Lys Leu 
945                 950                 955                 960 


Asn Glu Leu Ile Glu Phe Glu Asn Asp Asn Glu Ile Lys Lys Lys Ile 
                965                 970                 975     


Asn Leu Asn Ser Leu Asp Ile Asp Glu Arg Lys Asn Leu Met Ser Asn 
            980                 985                 990         


Ile Asp Gln Lys Lys Leu Ile Lys  Glu Ile Asp Lys Leu  Ile Val Thr 
        995                 1000                 1005             


Glu Lys  Asn Asn Ile Glu Lys  Asn Ile Leu Leu Lys  Leu Ile Phe 
    1010                 1015                 1020             


Asn Ser  Asn Phe Leu Glu Lys  Tyr Lys Lys Glu Ile  Asp Asn Leu 
    1025                 1030                 1035             


Ile Glu  Asp Thr Glu Ser Glu  Asn Glu Asn Lys Phe  Glu Lys Ile 
    1040                 1045                 1050             


Tyr Tyr  Pro Glu Glu His Lys  Asn Glu Leu Tyr Ile  Tyr Lys Lys 
    1055                 1060                 1065             


Asn Leu  Phe Leu Asn Ile Glu  Asn Pro Asn Phe Asp  Lys Ile Tyr 
    1070                 1075                 1080             


Gly Ile  Ile Ser Glu Asp Ile  Lys Asn Val Asp Thr  Lys Ile Leu 
    1085                 1090                 1095             


Phe Ala  Asp Asp Ile Arg Asn  Asn Lys Ile Val Glu  Thr Asp Gly 
    1100                 1105                 1110             


Ile Leu  Lys Asn Leu Asn Asn  Lys Leu Asn Gly Tyr  Ser Lys Glu 
    1115                 1120                 1125             


Tyr Lys  Glu Lys Tyr Val Asn  Lys Leu Lys Glu Asn  Asn Asp Phe 
    1130                 1135                 1140             


Phe Ile  Lys Asn Val Gln Asn  Glu Asn Tyr Lys Ser  Phe Glu Gly 
    1145                 1150                 1155             


Phe Glu  Glu Asp Tyr Asn Arg  Val Ser Glu Tyr Lys  Lys Ile Arg 
    1160                 1165                 1170             


Asp Leu  Val Glu Phe Asn Tyr  Leu Asn Lys Ile Glu  Ser Tyr Leu 
    1175                 1180                 1185             


Ile Asp  Ile Asn Trp Lys Leu  Ala Ile Gln Met Thr  Arg Phe Glu 
    1190                 1195                 1200             


Arg Asp  Met His Tyr Ile Val  Asn Gly Leu Asp Tyr  Leu Tyr Ile 
    1205                 1210                 1215             


Leu Arg  Leu Glu Arg Asp Arg  Asn Gln Asn Ile Ser  Ser Pro Tyr 
    1220                 1225                 1230             


Pro Lys  Tyr Lys Tyr Ile Asp  Lys Glu Asp Lys Ile  Lys Gly Arg 
    1235                 1240                 1245             


Lys Leu  Asp Tyr Ser Thr Ser  Tyr Tyr Asn Phe Lys  Asp Tyr Gln 
    1250                 1255                 1260             


Glu Phe  Met Glu Ile Cys Ser  Lys Phe Gly Ile Asp  Leu Ser Glu 
    1265                 1270                 1275             


Asn Ser  Glu Ile Asn Lys Pro  Glu Asn Glu Ser Ile  Arg Asn Tyr 
    1280                 1285                 1290             


Ile Ser  His Phe Tyr Ile Val  Arg Asn Pro Phe Ala  Asp Tyr Ser 
    1295                 1300                 1305             


Ile Ala  Glu Gln Ile Asp Arg  Val Ser Asn Leu Leu  Ser Tyr Ser 
    1310                 1315                 1320             


Thr Arg  Tyr Asn Asn Ser Thr  Tyr Ala Ser Val Phe  Glu Val Phe 
    1325                 1330                 1335             


Lys Lys  Asp Val Asp Leu Asp  Tyr Asp Glu Leu Lys  Lys Lys Phe 
    1340                 1345                 1350             


Lys Leu  Ile Gly Asn Thr Asp  Ile Leu Lys Arg Leu  Met Lys Pro 
    1355                 1360                 1365             


Lys Lys  Val Ser Val Leu Glu  Leu Glu Ser Tyr Asn  Ser Asn Tyr 
    1370                 1375                 1380             


Ile Lys  Asn Leu Ile Ile Glu  Leu Leu Thr Lys Val  Glu Asn Lys 
    1385                 1390                 1395             


Asp Glu  Ile Phe Ser 
    1400             


<210>  42
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  42

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Gly Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Asn Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Lys Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys His Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr Tyr Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Glu 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Lys Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Lys Ile Pro His Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Ala Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Leu Lys Glu Leu Lys Glu Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn Tyr Arg Met Gln Gln Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Lys Lys Asp Glu Lys Phe Asn Asp Lys Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Thr Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Glu Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Lys  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  43
<211>  949
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  43

Met Pro His Gln Lys Lys Met Ala Glu Arg Ile Lys Phe Val Asn Tyr 
1               5                   10                  15      


Gly Tyr Tyr Leu Arg Leu Lys Lys Asn Cys Ala Asp Ser Phe Glu Tyr 
            20                  25                  30          


Tyr Trp Cys Asp Tyr Ile Lys Glu Phe Ile Glu Glu Asn Tyr Val Thr 
        35                  40                  45              


Lys Ile Lys Glu Ala Lys Gly Lys Asn Gly Arg Gln Leu Thr Glu Glu 
    50                  55                  60                  


Asn Cys Asn Ser Glu Ala Met Leu Ser Lys Cys Trp His Asp Met Ile 
65                  70                  75                  80  


Arg His Met Cys Ala Lys Tyr Met Asp Leu Gly Lys Ala Val Tyr His 
                85                  90                  95      


Phe Met Leu Pro Gly Lys Ala Glu Gly Asn Asp Leu Cys Leu Asp Arg 
            100                 105                 110         


Leu Asn Asp Ser Phe Ser Lys Gly Ile Thr Ser Phe Asp Tyr Glu Asn 
        115                 120                 125             


Ile Lys Ala Glu Glu Asn Leu Gln Lys Ala Met Phe Gly Val Leu Val 
    130                 135                 140                 


Ser Gly Thr Phe Asn Phe Ser Arg Ser Val Ala Asp Tyr Ser Gly Pro 
145                 150                 155                 160 


Ala Ala Ala Lys Leu Ala Lys Glu Leu Arg Ala Glu Gly Lys Thr Leu 
                165                 170                 175     


Asn Glu Asp Val Leu Met Val Asp Glu Ala His Leu Lys Ala Ile Leu 
            180                 185                 190         


Tyr Ser Asp Ala Lys Arg Lys Leu Leu Arg Tyr Phe Gly Gly Ser Ser 
        195                 200                 205             


Ala Cys Glu Ala Leu Gly Leu Asp Lys Asp Lys Met Val Leu Glu Phe 
    210                 215                 220                 


Arg Gln Ile Phe Arg Gly Leu Arg Asn Ser Ala Phe His Tyr Thr Asp 
225                 230                 235                 240 


Gly Lys Lys Ala Asp Ile Lys Phe Asp Val Thr Arg Gln Leu Trp Ile 
                245                 250                 255     


Gln Asp Val Gln Ala Asn Lys Gln Leu Ile Leu Asp Lys Tyr Tyr Ser 
            260                 265                 270         


Asn Asn Val Cys Arg Tyr Tyr Lys Pro Glu Met Val Lys Lys Leu Ile 
        275                 280                 285             


Gly Asn Leu Tyr His Gly Tyr Val Glu Gln Glu Ala Gln Ile Pro Ala 
    290                 295                 300                 


Phe Arg Thr Val Trp Lys Arg Lys Asp Phe Ala Lys Tyr Leu Asn Asp 
305                 310                 315                 320 


Ser Asn Phe Leu Pro Val Asn Ile Lys Asn Asp Val Lys Glu Arg Thr 
                325                 330                 335     


Val Phe Glu Gly Ala Leu Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg 
            340                 345                 350         


Lys Tyr Thr Val Gly Gln Asp Ala Pro Lys Tyr Phe Phe Glu Ala Val 
        355                 360                 365             


Arg Ala Tyr Ser Asp Glu His Ala Lys Asn Lys Gln Asp Pro Tyr Ala 
    370                 375                 380                 


Asn Gln Ala Lys Asn Phe Trp Asp Tyr Val Glu Lys Leu Gln Lys Ser 
385                 390                 395                 400 


Tyr Glu Lys Gly Thr Leu Thr Phe Gly Ala Val Cys Gln Thr Ile Met 
                405                 410                 415     


Thr Glu Phe Val Gln Gln Asn Ser Lys Ala Thr Glu Lys Glu Gly Glu 
            420                 425                 430         


Ile Tyr Gln His Phe Lys Val Leu Phe Pro Leu Cys Met Gln Arg Gly 
        435                 440                 445             


Phe Glu Lys Tyr Val Lys Glu Lys His Gly Tyr Leu Leu Lys Pro Trp 
    450                 455                 460                 


Leu Asp Thr Val Val Arg Glu Asn Val Leu Gln Asp Ala Ala Ile Thr 
465                 470                 475                 480 


Cys Phe Asp Asp Leu Met Arg Asp Ala Glu Asp Arg Glu Tyr Ser Trp 
                485                 490                 495     


Tyr Val Val Ala His Phe Ile His Pro Lys Lys Leu Asn His Phe Val 
            500                 505                 510         


Gly Ala Leu Lys Asp Tyr Leu Gln Phe Lys Gln Asp Ile Phe Arg Arg 
        515                 520                 525             


Cys Ser Phe Ala Asn Ile Tyr Ser Glu Gly Glu Leu Ser Gln Lys Lys 
    530                 535                 540                 


Ala Met Leu Ala Glu Lys Glu Ala Glu Ile Ser Glu Ile Leu Arg Val 
545                 550                 555                 560 


Met Glu Phe Val Arg Gly Ile Thr Gly Arg Val Ser Lys Thr Phe Ser 
                565                 570                 575     


Asp Tyr Tyr Glu Asn Glu Glu Val Tyr Ala Asn Tyr Leu Gly Lys Tyr 
            580                 585                 590         


Ile Asp Phe Pro Lys Thr Asp Gly Ile Ser Val Phe Glu Ser Phe Arg 
        595                 600                 605             


Asp Phe Cys Thr Asn Thr Leu Pro Asp Gly Asn Val Leu Asp Val Tyr 
    610                 615                 620                 


Met Asp Glu Lys Asn Pro Arg Leu Leu Lys Asn Val Glu Leu Ala Arg 
625                 630                 635                 640 


Met Tyr Ala Gly Gly Asp Val Ala Leu Lys Lys Arg Lys Arg Ile Thr 
                645                 650                 655     


Ala Lys Asp Leu Gln Arg Tyr Tyr Gly Asn Glu Val Ala Val Gln Lys 
            660                 665                 670         


Ile Leu Gln Lys Gly Leu Cys Ser Thr Arg Glu Glu Gln Gln Arg Val 
        675                 680                 685             


Leu Glu Gln Gln Asn Leu Arg Gly Arg Ile Thr Leu Asn Asp Val Thr 
    690                 695                 700                 


Glu Ile Gln Glu Ile Ile Ser Asp Met Leu Ser Gln Leu Val Thr Phe 
705                 710                 715                 720 


Ser Tyr Phe Arg Glu Arg Asp Gln Met Tyr Leu Leu Leu Gly Phe Tyr 
                725                 730                 735     


Tyr Met Ala Leu Gln Thr Asn Arg Gly Ser Ser Trp Gly Asn Glu Thr 
            740                 745                 750         


Ile Asp Phe Cys Ala Gly Lys Lys Ile Ser Ile Lys Gln Gly Trp Val 
        755                 760                 765             


Leu His Gln Val Arg Ser Val Phe Thr Tyr Gly Leu Lys Leu Tyr Ser 
    770                 775                 780                 


Glu Leu Asp Glu Lys Gly Val Gly Gly Gln Leu Ser Ser Lys Ile Val 
785                 790                 795                 800 


Ala Phe Glu Arg Val His Arg Thr Ser Leu Ala Cys Ala Leu Arg Leu 
                805                 810                 815     


Phe Met Asp Glu Asn Cys Ser Arg Arg Ala Val Asp Val Arg Asn Tyr 
            820                 825                 830         


Val Asp His Phe Lys Tyr Tyr Phe Lys Ala Asp Arg Ser Ile Met Glu 
        835                 840                 845             


Leu Tyr Ser Ala Tyr Tyr Asp Cys Phe Phe Asp Tyr Ser Thr Lys Met 
    850                 855                 860                 


Arg Lys Ser Val Leu Leu Asn Phe Ile Ser Ile Leu Glu Arg His Phe 
865                 870                 875                 880 


Val Val Ser Lys Leu Arg Val Asn Cys Leu Glu Glu Arg Cys Ser Val 
                885                 890                 895     


Ser Phe Ala Glu Ser Leu Lys Ser Glu Lys Phe Thr Tyr Lys Leu Glu 
            900                 905                 910         


Ala Asp Ala Asn Lys Lys Ser Lys Glu Gln Thr Val Glu Phe Pro Ala 
        915                 920                 925             


Arg Asp Lys Glu Phe Leu Glu Ser Leu Gln Ala Glu Leu Glu Tyr Lys 
    930                 935                 940                 


Glu Gly Tyr Asn Ser 
945                 


<210>  44
<211>  949
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  44

Met Pro His Gln Lys Lys Met Ala Glu Arg Ile Lys Phe Val Asn Tyr 
1               5                   10                  15      


Gly Tyr Tyr Leu Arg Leu Lys Lys Asn Cys Ala Asp Ser Phe Glu Tyr 
            20                  25                  30          


Tyr Trp Cys Asp Tyr Ile Lys Glu Phe Ile Glu Glu Asn Tyr Val Thr 
        35                  40                  45              


Lys Ile Lys Glu Ala Lys Gly Lys Asn Gly Arg Gln Leu Thr Glu Glu 
    50                  55                  60                  


Asn Cys Asn Ser Glu Ala Met Leu Ser Lys Cys Trp His Asp Met Ile 
65                  70                  75                  80  


Arg His Met Cys Ala Lys Tyr Met Asp Leu Gly Lys Ala Val Tyr His 
                85                  90                  95      


Phe Met Leu Pro Gly Lys Ala Glu Gly Asn Asp Leu Cys Leu Asp Arg 
            100                 105                 110         


Leu Asn Asp Ser Phe Ser Lys Gly Ile Thr Ser Phe Asp Tyr Glu Asn 
        115                 120                 125             


Ile Lys Ala Glu Glu Asn Leu Gln Lys Ala Met Phe Gly Val Leu Val 
    130                 135                 140                 


Ser Gly Thr Phe Asn Phe Ser Arg Ser Val Ala Asp Tyr Ser Gly Pro 
145                 150                 155                 160 


Ala Ala Ala Lys Leu Ala Lys Glu Leu Arg Ala Glu Gly Lys Thr Leu 
                165                 170                 175     


Asn Glu Asp Val Leu Met Val Asp Glu Ala His Leu Lys Ala Ile Leu 
            180                 185                 190         


Tyr Ser Asp Ala Lys Arg Lys Leu Leu Arg Tyr Phe Gly Gly Ser Ser 
        195                 200                 205             


Ala Cys Glu Ala Leu Gly Leu Asp Lys Asp Lys Met Val Leu Glu Phe 
    210                 215                 220                 


Arg Gln Ile Phe Arg Gly Leu Arg Asn Ser Ala Phe His Tyr Thr Asp 
225                 230                 235                 240 


Gly Lys Lys Ala Asp Ile Lys Phe Asp Val Thr Arg Gln Leu Trp Ile 
                245                 250                 255     


Gln Asp Val Gln Ala Asn Lys Gln Leu Ile Leu Asp Lys Tyr Tyr Ser 
            260                 265                 270         


Asn Asn Val Cys Arg Tyr Tyr Lys Pro Glu Met Val Lys Lys Leu Ile 
        275                 280                 285             


Gly Asn Leu Tyr His Gly Tyr Val Glu Gln Glu Ala Gln Ile Pro Ala 
    290                 295                 300                 


Phe Arg Thr Val Trp Lys Arg Lys Asp Phe Ala Lys Tyr Leu Asn Asp 
305                 310                 315                 320 


Ser Asn Phe Leu Pro Val Asn Ile Lys Asn Asp Val Lys Glu Arg Thr 
                325                 330                 335     


Val Phe Glu Gly Ala Leu Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg 
            340                 345                 350         


Lys Tyr Thr Val Gly Gln Asp Ala Pro Lys Tyr Phe Phe Glu Ala Val 
        355                 360                 365             


Arg Ala Tyr Ser Asp Glu His Ala Lys Asn Lys Gln Asp Pro Tyr Ala 
    370                 375                 380                 


Asn Gln Ala Lys Asn Phe Trp Asp Tyr Val Glu Lys Leu Gln Lys Ser 
385                 390                 395                 400 


Tyr Glu Lys Gly Thr Leu Thr Phe Gly Ala Val Cys Gln Thr Ile Met 
                405                 410                 415     


Thr Glu Phe Val Gln Gln Asn Ser Lys Ala Thr Glu Lys Glu Gly Glu 
            420                 425                 430         


Ile Tyr Gln His Phe Lys Val Leu Phe Pro Leu Cys Met Gln Arg Gly 
        435                 440                 445             


Phe Glu Lys Tyr Val Lys Glu Lys His Gly Tyr Leu Leu Lys Pro Trp 
    450                 455                 460                 


Leu Asp Thr Val Val Arg Glu Asn Val Leu Gln Asp Ala Ala Ile Thr 
465                 470                 475                 480 


Cys Phe Asp Asp Leu Met Arg Asp Ala Glu Asp Arg Glu Tyr Ser Trp 
                485                 490                 495     


Tyr Val Val Ala His Phe Ile His Pro Lys Lys Leu Asn His Phe Val 
            500                 505                 510         


Gly Ala Leu Lys Asp Tyr Leu Gln Phe Lys Gln Asp Ile Phe Arg Arg 
        515                 520                 525             


Cys Ser Phe Ala Asn Ile Tyr Ser Glu Gly Glu Leu Ser Gln Lys Lys 
    530                 535                 540                 


Ala Met Leu Ala Glu Lys Glu Ala Glu Ile Ser Glu Ile Leu Arg Val 
545                 550                 555                 560 


Met Glu Phe Val Arg Gly Ile Thr Gly Arg Val Ser Lys Thr Phe Ser 
                565                 570                 575     


Asp Tyr Tyr Glu Asn Glu Glu Val Tyr Ala Asn Tyr Leu Gly Lys Tyr 
            580                 585                 590         


Ile Asp Phe Pro Lys Thr Asp Gly Ile Ser Val Phe Glu Ser Phe Arg 
        595                 600                 605             


Asp Phe Cys Thr Asn Thr Leu Pro Asp Gly Asn Val Leu Asp Val Tyr 
    610                 615                 620                 


Met Asp Glu Lys Asn Pro Arg Leu Leu Lys Asn Val Glu Leu Ala Arg 
625                 630                 635                 640 


Met Tyr Ala Gly Gly Asp Val Ala Leu Lys Lys Arg Lys Arg Ile Thr 
                645                 650                 655     


Ala Lys Asp Leu Gln Arg Tyr Tyr Gly Asn Glu Val Ala Val Gln Lys 
            660                 665                 670         


Ile Leu Gln Lys Gly Leu Cys Ser Thr Arg Glu Glu Gln Gln Arg Val 
        675                 680                 685             


Leu Glu Gln Gln Asn Leu Arg Gly Arg Ile Thr Leu Asn Asp Val Thr 
    690                 695                 700                 


Glu Ile Gln Glu Ile Ile Ser Asp Met Leu Ser Gln Leu Val Thr Phe 
705                 710                 715                 720 


Ser Tyr Phe Arg Glu Arg Asp Gln Met Tyr Leu Leu Leu Gly Phe Tyr 
                725                 730                 735     


Tyr Met Ala Leu Gln Thr Asn Arg Gly Ser Ser Trp Gly Asn Glu Thr 
            740                 745                 750         


Ile Asp Phe Cys Ala Gly Lys Lys Ile Ser Ile Lys Gln Gly Trp Val 
        755                 760                 765             


Leu His Gln Val Arg Ser Val Phe Thr Tyr Gly Leu Lys Leu Tyr Ser 
    770                 775                 780                 


Glu Leu Asp Glu Lys Gly Val Gly Gly Gln Leu Ser Ser Lys Ile Val 
785                 790                 795                 800 


Ala Phe Glu Arg Val His Arg Thr Ser Leu Ala Cys Ala Leu Arg Leu 
                805                 810                 815     


Phe Met Asp Glu Asn Cys Ser Arg Arg Ala Val Asp Val Arg Asn Tyr 
            820                 825                 830         


Val Asp His Phe Lys Tyr Tyr Phe Lys Ala Asp Arg Ser Ile Met Glu 
        835                 840                 845             


Leu Tyr Ser Ala Tyr Tyr Asp Cys Phe Phe Asp Tyr Ser Thr Lys Met 
    850                 855                 860                 


Arg Lys Ser Val Leu Leu Asn Phe Ile Ser Ile Leu Glu Arg His Phe 
865                 870                 875                 880 


Val Val Ser Lys Leu Arg Val Asn Cys Leu Glu Glu Arg Cys Ser Val 
                885                 890                 895     


Ser Phe Ala Glu Ser Leu Lys Ser Glu Lys Phe Thr Tyr Lys Leu Glu 
            900                 905                 910         


Ala Asp Ala Asn Lys Lys Ser Lys Glu Gln Thr Val Glu Phe Pro Ala 
        915                 920                 925             


Arg Asp Lys Glu Phe Leu Glu Ser Leu Gln Ala Glu Leu Glu Tyr Lys 
    930                 935                 940                 


Glu Gly Tyr Asn Ser 
945                 


<210>  45
<211>  1143
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  45

Met Arg Val Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Val Tyr Ser Gly 
            20                  25                  30          


Gln Pro Val Ser Asn Glu Thr Cys Asn Ile Leu Pro Glu Lys Lys Arg 
        35                  40                  45              


Gln Ser Phe Asp Leu Ser Ile Glu Asn Lys Thr Leu Lys Arg Arg Asp 
    50                  55                  60                  


Asp Val Asp Lys Thr Lys Lys Gly Lys Tyr Asp Ile Val Arg Lys Ile 
65                  70                  75                  80  


Ile Lys Tyr Gly Glu Leu Pro Gln Ser Ile Asn Asp Val Asp Ile Leu 
                85                  90                  95      


Glu Phe Leu Asn His Lys Phe Gln Lys Pro Val Lys Tyr Trp Lys Asn 
            100                 105                 110         


Gly Lys Glu Glu Ser Phe Asn Leu Thr Leu Leu Ile Val Glu Ala Val 
        115                 120                 125             


Lys Thr Gln Asp Arg Gln Lys Leu Gln Pro Tyr Tyr Asp Trp Lys Thr 
    130                 135                 140                 


Trp Tyr Ile Gln Thr Lys Ser Asp Leu Leu Lys Lys Ser Ile Glu Asn 
145                 150                 155                 160 


Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg Lys Lys Ala Leu 
                165                 170                 175     


Leu Ala Trp Glu Thr Glu Phe Thr Thr Ser Gly Lys Ile Asp Leu Thr 
            180                 185                 190         


His Tyr His Lys Val Tyr Met Thr Asp Val Leu Cys Thr Ala Leu Gln 
        195                 200                 205             


Lys Val Glu Pro Ser Thr Asp Lys Lys Gly Lys Ile Asn Thr Asn Ala 
    210                 215                 220                 


Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Thr His Gln Pro Ala Ile 
225                 230                 235                 240 


Phe Gly Thr Arg Gln Ala Pro Asn Asn Val Asn Arg Ala Asp Asp Arg 
                245                 250                 255     


Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu Glu His Tyr Phe 
            260                 265                 270         


Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Ala Asp Asp Ile Glu His 
        275                 280                 285             


Tyr Leu Lys Thr Gln Thr Leu Lys Thr Thr Ile Glu Lys Gln Leu Val 
    290                 295                 300                 


Asn Ala Ile Arg Ala Asn Ile Ile Gln Gln Gly Lys Thr Asn His His 
305                 310                 315                 320 


Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile Arg Ile Lys Thr 
                325                 330                 335     


Asn Glu Ala Phe Val Leu Asn Leu Thr Gly Thr Cys Ala Phe Ala Ala 
            340                 345                 350         


Asn Asn Ile Arg Asn Met Val Asp Asn Glu Gln Thr Asn Asp Ile Leu 
        355                 360                 365             


Gly Lys Gly Asp Phe Ile Lys Ser Leu Leu Lys Asp Asn Thr Asn Gly 
    370                 375                 380                 


Gln Leu Tyr Ser Phe Phe Phe Gly Glu Ser Leu Ser Thr Asn Lys Ala 
385                 390                 395                 400 


Glu Lys Glu Thr Gln Leu Trp Gly Ile Arg Gly Ala Val Gln Gln Ile 
                405                 410                 415     


Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu Lys Thr Val Phe 
            420                 425                 430         


Asn Ile Ser Asn Phe Glu Asn Pro Thr Ile Thr Asp Pro Lys Gln Gln 
        435                 440                 445             


Thr Asn Tyr Ala Asp Thr Ile Tyr Lys Ala Leu Phe Ile Lys Glu Leu 
    450                 455                 460                 


Glu Lys Ile Pro Asn Ala Phe Ala Gln Gln Leu Lys Thr Gly Gly Ala 
465                 470                 475                 480 


Leu Ser Tyr Tyr Thr Ile Glu Asn Leu Lys Ser Leu Leu Thr Thr Phe 
                485                 490                 495     


Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala Pro Gly Phe Lys 
            500                 505                 510         


Lys Val Phe Asn Gly Gly Ile Asn Tyr Gln Asn Ala Lys Gln Asp Glu 
        515                 520                 525             


Ser Phe Tyr Glu Leu Met Leu Glu Arg Tyr Leu Arg Lys Glu Asn Phe 
    530                 535                 540                 


Ala Glu Glu Ala Tyr Asn Ala Arg Tyr Phe Leu Leu Lys Leu Ile Tyr 
545                 550                 555                 560 


Asn Asn Leu Phe Leu Pro Gly Phe Thr Arg Asp Arg Lys Ala Phe Ala 
                565                 570                 575     


Asp Ser Val Gly Phe Val Gln Met Gln Asn Lys Lys Gln Ala Glu Lys 
            580                 585                 590         


Val Asn Pro Lys Lys Arg Glu Ala Tyr Ala Phe Glu Ala Val Arg Pro 
        595                 600                 605             


Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala Tyr Val Gln Ser 
    610                 615                 620                 


Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys Ala Thr Asp Glu 
625                 630                 635                 640 


Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val Phe Val Lys Gly 
                645                 650                 655     


Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe Val Gln Val Pro 
            660                 665                 670         


Gln Pro Gln Leu Thr Ala Thr Ala Ser Asn Gln Gln Lys Ala Asp Lys 
        675                 680                 685             


Leu Asn Gln Leu Glu Ala Ser Ile Thr Ala Asp Cys Lys Leu Thr Pro 
    690                 695                 700                 


Gln Tyr Ala Lys Ala Asp Asn Ala Thr His Ile Ala Phe Tyr Val Phe 
705                 710                 715                 720 


Cys Lys Leu Leu Asp Ala Gly His Leu Ser Asn Leu Arg Asn Glu Leu 
                725                 730                 735     


Ile Lys Phe Arg Glu Ser Val Asn Glu Phe Lys Phe His His Leu Leu 
            740                 745                 750         


Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val Val Pro Thr Asp 
        755                 760                 765             


Tyr Arg Asp Leu Tyr Ser Ser Glu Ala Asp Cys Leu Ala Arg Leu Arg 
    770                 775                 780                 


Pro Phe Ile Glu Gln Gly Ala Asp Ile Thr Asn Trp Ser Asp Leu Phe 
785                 790                 795                 800 


Val Gln Ser Asp Lys His Ser Pro Val Ile His Ala Asn Ile Glu Leu 
                805                 810                 815     


Ser Val Lys Tyr Gly Thr Thr Lys Leu Leu Glu Gln Ile Ile Asn Lys 
            820                 825                 830         


Asp Pro Gln Phe Lys Thr Thr Glu Ala Asn Phe Thr Ala Trp Asn Thr 
        835                 840                 845             


Ala Gln Lys Ser Ile Glu Gln Leu Ile Lys Gln Arg Glu Asp His His 
    850                 855                 860                 


Glu Gln Trp Val Lys Ala Lys Asn Ala Asp Asp Lys Glu Lys Gln Glu 
865                 870                 875                 880 


Arg Lys Arg Glu Lys Ser Asn Phe Ala Gln Lys Phe Ile Glu Lys His 
                885                 890                 895     


Gly Asp Asp Tyr Leu Asp Ile Cys Asp Tyr Ile Asn Thr Tyr Asn Trp 
            900                 905                 910         


Leu Asp Asn Lys Met His Phe Val His Leu Asn Arg Leu His Gly Leu 
        915                 920                 925             


Thr Ile Glu Leu Leu Gly Arg Met Ala Gly Phe Val Ala Leu Phe Asp 
    930                 935                 940                 


Arg Asp Phe Gln Met Leu Asp Ala Lys Arg Ile Ser Asp Leu Tyr Gln 
945                 950                 955                 960 


Leu Lys Ser Phe Ile Ser Phe Arg Glu Ile Thr Ser Glu Leu Asp Lys 
                965                 970                 975     


Asn Asn Asp Ile Thr Glu Ile Asn Leu Ile Lys Asp Lys Glu Ile Ile 
            980                 985                 990         


Lys Arg Asp Gly Thr Pro Ile Thr  Glu Ala Asp Arg Asn  Ser Leu Lys 
        995                 1000                 1005             


Ser Cys  Ile Gln Ser Lys Arg  Glu Tyr Tyr Gln Lys  Thr Tyr Phe 
    1010                 1015                 1020             


Lys Glu  His Thr Asn Pro Phe  Thr Asp Arg Asn Tyr  Ile Ala His 
    1025                 1030                 1035             


Phe Asn  Tyr Leu Ser Thr Asn  Thr Gly Asn His Ser  Leu Ile Lys 
    1040                 1045                 1050             


Leu Ile  Asn Lys Leu Arg Asp  Leu Leu His Tyr Asp  Arg Lys Leu 
    1055                 1060                 1065             


Lys Asn  Ala Val Ser Lys Ala  Phe Ile Asp Leu Phe  Asp Lys His 
    1070                 1075                 1080             


Gly Met  Ile Leu Lys Leu Lys  Leu Asn Thr Asp His  Gln Leu Glu 
    1085                 1090                 1095             


Val Glu  Ser Leu Glu Pro Lys  Lys Ile Tyr His Leu  Gly Ser Ser 
    1100                 1105                 1110             


Ala Lys  Asp Lys Pro Glu Tyr  Gln Tyr Cys Thr Asn  Gln Val Met 
    1115                 1120                 1125             


Met Ala  Tyr Cys Asn Met Cys  Arg Ser Leu Leu Glu  Met Lys Lys 
    1130                 1135                 1140             


<210>  46
<211>  1425
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  46

Met Lys Leu Ser Lys Val Asp Arg Ile Arg Val Ala Val Gly Lys Thr 
1               5                   10                  15      


Gly Lys Thr Glu Asn Gly Asn Ser Gln Gly Arg Gly Val Leu Tyr Arg 
            20                  25                  30          


Ser Pro Lys Gly Asn Lys Thr Val Ala Val Asp Ala Val Val Glu Glu 
        35                  40                  45              


Arg Ile Arg Asn Ala Asn Arg Leu Tyr Ser Ala Phe Phe Arg Cys Ala 
    50                  55                  60                  


Tyr Pro Glu Glu Pro Glu Arg His Phe Glu Glu Ile Ile Lys Arg Met 
65                  70                  75                  80  


Ala Thr Gly Lys Lys Ser Gly Ala Gln Ile Leu Lys Glu Tyr Ile Gly 
                85                  90                  95      


Tyr Glu Gly Gln Lys Asn Arg Lys Pro Tyr Thr Phe Tyr Val Asn Lys 
            100                 105                 110         


Cys Ala Tyr Arg Pro Ala Gly Lys Glu Leu Gly Gln Val Leu Arg Leu 
        115                 120                 125             


Phe Val Lys Glu Arg Leu Gly Gln Asn Trp Gln Asn Pro Glu Ala Ala 
    130                 135                 140                 


Glu Ala Ala Val Ala Leu Leu Thr Cys Leu Cys Glu Gly Lys Thr Asn 
145                 150                 155                 160 


Arg Tyr Thr Glu Asn Thr Ala Asp Gly Pro Val Leu Thr Glu Leu Ser 
                165                 170                 175     


Glu Gln Thr Val Thr Gln Leu Glu Gln Val Ser Arg Leu Gly Gly Ser 
            180                 185                 190         


Ile Leu Val Pro Lys Thr Glu Arg Leu Glu Thr Ile Val Thr Val Ile 
        195                 200                 205             


Leu Arg Leu Thr Ala Glu Gln Cys Asn Thr Ser Leu Tyr Val Asn Gly 
    210                 215                 220                 


Gly Thr Lys Glu Ala Gln Asp Ala Asp Leu Glu Lys Gln Ile Ala Leu 
225                 230                 235                 240 


Leu Lys Ser Leu Gln Thr Lys Pro Leu Leu Leu Lys Glu Arg Phe Asp 
                245                 250                 255     


Lys Val Thr Lys Gln Thr Ile Arg Asp Glu Gln Lys Leu Ser Glu Phe 
            260                 265                 270         


Ser Tyr Lys Asp Ala Thr Lys Glu Arg Met Glu Ala Val Val Val Arg 
        275                 280                 285             


Met Arg Lys Thr Leu Lys Lys Gly Ala Ser Arg Glu Val Ala Val Glu 
    290                 295                 300                 


Leu Leu Gln Ala Leu Ala Gln Tyr Asp Gly Lys Thr Trp Asp Gly Trp 
305                 310                 315                 320 


Leu Thr Gln Met Leu Glu Thr Glu Ala Ser Lys Lys Lys Leu Lys Asp 
                325                 330                 335     


Phe Ile Leu Ala Val Asn Lys Asp Phe His His Phe His Val Ile Lys 
            340                 345                 350         


Ser Val Lys Asn Thr Ala Val Ala Val Ser His Ser Glu Asp Asn Thr 
        355                 360                 365             


Leu Gln Leu Ser Gly Ala Lys Lys Lys Thr Lys Gly Ala Met Gln Asp 
    370                 375                 380                 


Ala Leu Phe Ala Tyr Ala Gln Ser Glu Glu Ser Ser Asp Glu Thr Leu 
385                 390                 395                 400 


His Arg Ile Lys Arg Ile Leu Phe Thr Tyr Val Leu Gly Gly Arg Gln 
                405                 410                 415     


Asp Asn Thr Leu Arg Leu Thr Glu Lys Thr His Leu Ala Lys Glu Leu 
            420                 425                 430         


Leu Trp Lys Phe Arg Gly Thr Gly Ala Gly Leu Phe Asp Ala Asp Phe 
        435                 440                 445             


Val Pro Glu Glu Glu Arg Ala Gly Glu Ser Gly Arg Lys Ala Gly Ser 
    450                 455                 460                 


Tyr Thr Asp Leu Gly Cys Leu Phe Ala Glu Asp Asp Gly Ile Arg Asn 
465                 470                 475                 480 


Gln Arg Arg Ile Ala Asp Arg Ile Asn Tyr Val Asn Tyr Gly Asn Tyr 
                485                 490                 495     


Leu Arg Met Arg Lys Ala Ala Glu Asp Glu Phe Thr Leu Phe Trp Cys 
            500                 505                 510         


Ala Tyr Ile Lys Asp Tyr Ile Glu Glu Asn Tyr Val Thr Lys Ile Arg 
        515                 520                 525             


Glu Ala Lys Arg Thr Gly Gly Lys Arg Arg Leu Lys Glu Thr Asp Cys 
    530                 535                 540                 


Glu Ala Glu Arg Met Met Glu Lys Cys Trp His Asp Ile Ile Arg Tyr 
545                 550                 555                 560 


Ile Cys Gly Lys Tyr Ile His Ile Gly Lys Ala Val Tyr His Phe Ala 
                565                 570                 575     


Ile Pro Glu Asp Leu Leu Ala Asn Pro Gly Glu Val Arg Ser Phe Gly 
            580                 585                 590         


Asp Val His Ala Lys Tyr Ala Asp Gly Ile Thr Ser Phe Asp Tyr Glu 
        595                 600                 605             


Asp Ile Lys Ala Glu Glu Asn Leu Gln Lys Ser Ile Phe Asn Val Leu 
    610                 615                 620                 


Val Ser Ala Val Ala Asn Tyr Ser Arg Ser Val Val Asp Leu Ser Ser 
625                 630                 635                 640 


Glu Arg Ala Glu Glu Leu Arg Arg Leu Pro Gly Asn Glu Arg Leu Asn 
                645                 650                 655     


Glu Asp Val Leu Met Met Lys Glu Thr His Leu Lys Glu Leu Leu Leu 
            660                 665                 670         


Pro Asp Ala Lys Lys Arg Leu Leu Arg Tyr Phe Gly Gly Tyr Ser Ala 
        675                 680                 685             


Cys Glu Gly Leu Ser Gly Val Thr Ser Glu Glu Leu Ala Trp Glu Met 
    690                 695                 700                 


Arg Thr Val Leu Ser Thr Leu Arg Asn Glu Ser Phe His Tyr Thr Phe 
705                 710                 715                 720 


Gly Lys Lys Lys Lys Leu Asp Tyr Lys Val Ala Lys Gln Leu Trp Met 
                725                 730                 735     


Gln Ala Ile Arg Ala Asn Arg Gln Leu Ile Leu Asp Lys Tyr Tyr Ser 
            740                 745                 750         


Asn Asn Thr Cys Arg Tyr Tyr Ser Pro Asn Ser Ile Lys Ala Leu Ile 
        755                 760                 765             


Glu Gln Gly Tyr Arg Ser Tyr Glu Glu Arg Glu Ala Gln Ile Pro Ala 
    770                 775                 780                 


Phe Lys Thr Val Trp Lys Lys Ala Glu Leu Ala Lys Tyr Leu Ala Asp 
785                 790                 795                 800 


Lys Lys Val Met Pro Ala Glu Ile Ser Gly Glu Glu Lys Glu Arg Val 
                805                 810                 815     


Ile Phe Gln Gly Ala Phe Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg 
            820                 825                 830         


Glu Phe Thr Val Gly Asn Thr Ala Ala Lys Tyr Phe Phe Asp Ala Val 
        835                 840                 845             


Glu Arg Tyr Cys Lys Glu Asn Glu Thr Gly Pro Tyr Lys Asn Pro Ala 
    850                 855                 860                 


Lys Ser Phe Asn Asp Tyr Val Asn Gly Ala Phe Asn Asn Lys Gly Val 
865                 870                 875                 880 


Lys Val Gln Lys Gly Leu Ser Asp Leu Tyr Arg Glu Gly Lys Ile Thr 
                885                 890                 895     


Phe Gly Val Val Cys Gln Thr Ile Met Ala Glu Tyr Thr Gln Gln Asn 
            900                 905                 910         


Glu Lys Ser Glu Gly Glu Ala Ile Tyr Gln His Phe Lys Met Leu Phe 
        915                 920                 925             


Pro Leu Cys Met Arg Lys Gly Phe Gln Lys Tyr Val Glu Glu Lys His 
    930                 935                 940                 


Lys Glu Leu Leu Gln Pro Val Ile Arg Glu Met Gly Ser Arg Glu Asp 
945                 950                 955                 960 


Phe Leu Thr Asn Ile His Ile Gly Cys Phe Asp Asp Phe Cys Arg Glu 
                965                 970                 975     


Asp Gly Met Tyr Glu Tyr Asp Trp Phe Val Val Ala His Leu Ile His 
            980                 985                 990         


Pro Lys Arg Leu Asn Glu Leu Val  Gly Asn Leu Lys Asp  Tyr Met Gln 
        995                 1000                 1005             


Phe Lys  Gln Asp Ile Leu Arg  Arg Ala Asp Tyr Val  Glu Gln Phe 
    1010                 1015                 1020             


Thr Lys  Glu Glu Leu Ala Ala  Met Lys Ala Arg Thr  Glu Glu Lys 
    1025                 1030                 1035             


Leu Gln  Lys Ile Ser Gly Ile  Leu Arg Val Ala Glu  Phe Val Arg 
    1040                 1045                 1050             


Gly Ile  Ala Gly Arg Val Ser  Asn Thr Phe Ser Asp  Tyr Tyr Glu 
    1055                 1060                 1065             


Ser Glu  Glu Ala Tyr Ala Ser  Tyr Leu Glu Gln Tyr  Ile Glu Phe 
    1070                 1075                 1080             


Pro Arg  Ile Lys Gly Ser Thr  Val Phe Glu Ser Phe  Arg Asp Phe 
    1085                 1090                 1095             


Cys Val  Asn Thr Leu Pro Gly  Gly Ala Val Met Asp  Val Tyr Met 
    1100                 1105                 1110             


Asp Glu  Lys Asn Pro Arg Ile  Leu Arg Asn Val Glu  Val Ala Arg 
    1115                 1120                 1125             


Met Tyr  Ala Gly Gly Asp Ile  Gly Leu Arg Thr Arg  Lys Lys Val 
    1130                 1135                 1140             


Thr Ala  Glu Glu Leu Lys Arg  Tyr Tyr Gln Asn Glu  Ala Glu Val 
    1145                 1150                 1155             


Ala Ala  Leu Leu Lys Ala Gly  Leu Cys Ala Thr Ala  Glu Asp Gln 
    1160                 1165                 1170             


Lys Arg  Val Lys Ala Gln Gln  Glu Leu Arg Asn Arg  Ile Thr Leu 
    1175                 1180                 1185             


Thr Asp  Val Thr Glu Ile Gln  Glu Val Ile Asn Asp  Leu Leu Ser 
    1190                 1195                 1200             


Gln Leu  Val Thr Phe Ser Tyr  Phe Arg Glu Arg Asp  Glu Met Tyr 
    1205                 1210                 1215             


Leu Leu  Leu Gly Phe Tyr Tyr  Met Ala Leu Gln Ser  Asp Gly Asp 
    1220                 1225                 1230             


Trp Gly  Glu Glu Leu Arg Val  Phe Asp Gly Lys Lys  Leu Gln Val 
    1235                 1240                 1245             


Glu Asn  Gly Phe Val Leu Tyr  Gln Leu Leu Ser Ala  Phe Thr Tyr 
    1250                 1255                 1260             


Gly Leu  Asn Met Tyr Ser Glu  Ala Ala Pro Asp Gly  Lys Gly Gly 
    1265                 1270                 1275             


Ser Gln  Ala Gly Lys Ile Gly  Glu Phe Ile Lys Ala  His Pro Asn 
    1280                 1285                 1290             


Ser Trp  Asp Arg Ala Leu Arg  Leu Phe Val Asp Asp  Gly Ala Cys 
    1295                 1300                 1305             


Glu Glu  Val Ser Arg Lys Ala  Arg Asn Tyr Val Asp  His Phe Arg 
    1310                 1315                 1320             


Tyr Tyr  Val Lys Pro Asp Arg  Ser Ile Met Asp Leu  Tyr Ala Val 
    1325                 1330                 1335             


Tyr His  Glu Tyr Phe Phe Asp  Tyr Ser Thr Lys Met  Arg Lys Ser 
    1340                 1345                 1350             


Val Leu  Gln Asn Phe Ala Ser  Ile Leu Glu Arg Tyr  Phe Val Leu 
    1355                 1360                 1365             


Thr Lys  Phe Lys Leu Gly Gly  Glu Arg Gly Ala Gln  Thr Leu Glu 
    1370                 1375                 1380             


Ala Glu  Leu Ser Gly Asp Lys  Phe Thr Tyr Lys Leu  Ser Asp Thr 
    1385                 1390                 1395             


Lys Ala  Lys Pro Val Val Leu  Pro Ala Arg Asn Lys  Glu Phe Leu 
    1400                 1405                 1410             


Glu Asn  Leu Lys Asn Glu Leu  Asn Tyr Arg Gln Glu  
    1415                 1420                 1425 


<210>  47
<211>  1185
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  47

Met Lys Val Thr Lys Ile Asp Gly Leu Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ile Glu Asp Ala Ser Gln Lys Asn Glu Thr 
            20                  25                  30          


Leu Glu Arg Leu Glu Asn Leu Lys Gly Ile Lys Leu Gly Ser Tyr Ile 
        35                  40                  45              


Lys Asn Pro Asp Lys Thr Lys Asn Lys Asp Asn Lys Lys Arg Arg Lys 
    50                  55                  60                  


Gly Leu Lys Glu Tyr Phe Ser Glu Ile Thr Leu Arg Lys Glu Asn Glu 
65                  70                  75                  80  


Lys Tyr Val Leu Leu Lys Gly Lys Lys Leu Lys Lys Ile Asn Asn Asp 
                85                  90                  95      


Ile Lys Asp Thr Asp Ile Lys Ala Lys Asp Lys Lys Glu Glu Val Phe 
            100                 105                 110         


Asp Ile Leu Lys Glu Ile Leu Lys Leu Asn Leu Leu Ala Asn Asp Ala 
        115                 120                 125             


Glu Glu Lys Ile Gln Phe Asp Ser Ile Lys Leu Lys Asn Val Phe Gly 
    130                 135                 140                 


Lys Asp Phe Ala Lys Lys Glu Leu Gln Ile Lys Ser Ile Glu Glu Ser 
145                 150                 155                 160 


Leu Glu Lys Asn Arg Ala Asp Tyr Arg Lys Glu Phe Ile Glu Ile Glu 
                165                 170                 175     


Asn His Lys Tyr Gly Asn Val Lys Gly Lys Asn Lys Arg Ser Arg Ile 
            180                 185                 190         


Tyr Gly Tyr Tyr Lys Lys Ser Glu Asn His Lys Lys Phe Glu Asp Asn 
        195                 200                 205             


Ile Arg Glu Ala Phe Glu Lys Leu Tyr Thr Glu Glu Asn Ile Lys Lys 
    210                 215                 220                 


Leu Tyr Ser Lys Ile Glu Glu Val Leu Lys Lys Thr His Leu Lys Ser 
225                 230                 235                 240 


Ile Val Arg Glu Phe Tyr Lys Asn Glu Ile Ile Gly Glu Ser Glu Phe 
                245                 250                 255     


Ser Lys Lys Asn Gly Asp Gly Ile Ser Ile Leu Tyr Asn Gln Ile Lys 
            260                 265                 270         


Asp Ser Ile Lys Lys Glu Glu Asn Phe Ile Glu Phe Ile Glu Asn Ile 
        275                 280                 285             


Gly Asn Leu Glu Leu Lys Asp Leu Thr Lys Ser Gln Ile Phe Tyr Lys 
    290                 295                 300                 


Tyr Phe Leu Glu Asn Glu Glu Leu Asn Asp Glu Asn Ile Lys Phe Val 
305                 310                 315                 320 


Phe Cys Tyr Phe Val Glu Ile Glu Val Ser Asp Leu Leu Lys Gly Asn 
                325                 330                 335     


Val Tyr Lys Ala Ser Lys Ile Tyr Glu Asn Lys Ile Lys Asn Ile Phe 
            340                 345                 350         


Glu Tyr Asp Lys Leu Lys Lys Leu Val Ile Asn Lys Leu Glu Asn Lys 
        355                 360                 365             


Leu Asn Asn Tyr Val Arg Asn Cys Gly Lys Tyr Asn Tyr His Met Glu 
    370                 375                 380                 


Asn Gly Asp Ile Ala Thr Ser Asp Ile Asn Met Arg Asn Arg Gln Thr 
385                 390                 395                 400 


Glu Ala Phe Leu Arg Ser Met Ile Gly Val Ser Ser Phe Gly Tyr Phe 
                405                 410                 415     


Ser Leu Arg Asn Ile Leu Gly Val Asn Asp Asp Asp Phe Tyr Glu Ile 
            420                 425                 430         


Glu Glu Asp Leu Thr Lys Asp Glu Arg Lys Lys Glu Ser Ser Thr Leu 
        435                 440                 445             


Lys Lys Val Lys Glu Asp Ile Ala Ser Lys Ser Ile Phe Glu Lys Val 
    450                 455                 460                 


Val Asp Lys Ser Phe Gln Lys Lys Gly Ile Tyr Asn Ile Lys Glu Asn 
465                 470                 475                 480 


Leu Lys Met Phe Tyr Gly Asp Ser Phe Asp Asp Ala Asp Glu Asp Glu 
                485                 490                 495     


Leu Lys Gln Phe Phe Val Asn Met Leu Asn Gly Ile Thr Ser Ile Arg 
            500                 505                 510         


His Arg Val Val His Tyr Asn Met Asn Thr Asn Ser Glu Asn Ile Phe 
        515                 520                 525             


Asn Phe Ser Asp Ile Glu Val Ser Arg Leu Leu Lys Asn Ile Phe Glu 
    530                 535                 540                 


Lys Glu Thr Asp Lys Arg Glu Leu Lys Leu Lys Ile Phe Lys Gln Leu 
545                 550                 555                 560 


Asn Ser Ala Gly Val Phe Asp Tyr Trp Glu Ser Trp Lys Ile Lys Lys 
                565                 570                 575     


Tyr Leu Glu Asn Ile Glu Phe Lys Phe Val Asn Lys Asn Ile Pro Phe 
            580                 585                 590         


Val Pro Ser Phe Thr Lys Leu Tyr Asn Arg Ile Asp Asn Leu Lys Gly 
        595                 600                 605             


Ser Asn Ala Leu Asn Leu Gly Tyr Ile Asn Ile Pro Lys Arg Lys Glu 
    610                 615                 620                 


Val Arg Asp Ser Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu 
625                 630                 635                 640 


Phe Val Glu Glu Phe Val Asn Asn Asn Asp Asn Phe Glu Lys Ile Phe 
                645                 650                 655     


Arg Glu Ile Ile Glu Ile Asn Lys Asn Ala Gly Thr Asn Thr Lys Thr 
            660                 665                 670         


Lys Phe Tyr Lys Leu Glu Lys Phe Glu Thr Leu Lys Ala Asn Thr Pro 
        675                 680                 685             


Thr Glu Tyr Leu Glu Lys Leu Gln Ser Leu His Gln Ile Asn Tyr Asp 
    690                 695                 700                 


Arg Glu Lys Ile Glu Glu Asp Lys Asp Ile Tyr Val Asp Phe Val Gln 
705                 710                 715                 720 


Lys Ile Phe Leu Lys Gly Phe Ile Asn Tyr Leu Gln Glu Ser Gly Ser 
                725                 730                 735     


Leu Lys Tyr Leu Leu Asn Leu Glu Lys Asn Glu Val Ile Ala Asn Lys 
            740                 745                 750         


Lys Ser Ser Tyr Asp Glu Lys Leu Lys Leu Trp Gln Asn Asn Gly Ser 
        755                 760                 765             


Asp Leu Ser Lys Met Pro Glu Glu Ile Tyr Glu Tyr Ile Lys Lys Ile 
    770                 775                 780                 


Lys Ile Asn Lys Ile Asn Tyr Ser Asp Arg Met Ser Ile Phe Tyr Leu 
785                 790                 795                 800 


Leu Leu Lys Leu Ile Asp Tyr Lys Glu Leu Thr Asn Leu Arg Gly Asn 
                805                 810                 815     


Leu Glu Lys Tyr Glu Ser Met Asn Lys Asn Lys Ile Tyr Ser Glu Glu 
            820                 825                 830         


Leu Asn Ile Val Asn Leu Val Ser Leu Asp Asn Asn Lys Val Arg Ala 
        835                 840                 845             


Asn Phe Glu Leu Glu Ala Glu Asp Val Arg Lys Phe Leu Lys Thr Glu 
    850                 855                 860                 


Thr Leu Ile Lys Asp Ala Arg Gln Leu Asn Asn Phe Ser Glu Arg Phe 
865                 870                 875                 880 


Ser Asp Gly Glu Asn Val Ile Lys His Arg Ser Phe Tyr Asn Ile Lys 
                885                 890                 895     


Lys Tyr Gly Ile Leu Asp Leu Leu Glu Lys Ile Val Ala Lys Ala Asp 
            900                 905                 910         


Leu Lys Ile Thr Lys Glu Glu Ile Lys Lys Tyr Glu Asn Leu Gln Lys 
        915                 920                 925             


Glu Leu Glu Lys Asn Asp Phe Tyr Lys Ile Gln Glu Lys Ile His Lys 
    930                 935                 940                 


Lys Tyr Asn Gln Lys Pro Asn Leu Ile Leu Arg Thr Glu Asn Lys Lys 
945                 950                 955                 960 


Asp Phe Asn Asp Tyr Lys Lys Ala Ile Glu Asn Ile Gln Asn Tyr Thr 
                965                 970                 975     


Gln Leu Lys Asn Lys Ile Glu Phe Asn Asp Leu Asn Leu Leu Gln Ser 
            980                 985                 990         


Leu Leu Phe Arg Ile Leu His Arg  Leu Ala Gly Tyr Thr  Ser Leu Trp 
        995                 1000                 1005             


Glu Arg  Asp Leu Gln Phe Lys  Leu Lys Gly Glu Phe  Pro Glu Asp 
    1010                 1015                 1020             


Lys Tyr  Ile Asp Glu Ile Phe  Asn Ser Asp Arg Asn  Asn Asn Gln 
    1025                 1030                 1035             


Lys Tyr  Lys Ser Gly Gly Ile  Ala Tyr Lys Tyr Val  Asp Phe Leu 
    1040                 1045                 1050             


Ile Glu  Lys Glu Glu Gly Lys  Arg Ala Gly Lys Asn  Lys Val Lys 
    1055                 1060                 1065             


Lys Arg  Ser Glu Lys Glu Gly  Ser Phe Ile Ile Arg  Asn Tyr Ile 
    1070                 1075                 1080             


Ala His  Phe Asn Tyr Ile Pro  Asp Ala Glu Lys Ser  Ile Leu Glu 
    1085                 1090                 1095             


Met Leu  Glu Glu Leu Arg Ala  Leu Leu Lys Tyr Asp  Arg Lys Leu 
    1100                 1105                 1110             


Lys Asn  Ala Val Met Lys Ser  Val Lys Asp Ile Phe  Lys Glu Tyr 
    1115                 1120                 1125             


Gly Phe  Ile Val Glu Phe Gly  Ile Ser His Glu Ser  Asn Ser Lys 
    1130                 1135                 1140             


Lys Ile  Lys Val Val Asn Val  Glu Ser Glu Lys Ile  Lys His Leu 
    1145                 1150                 1155             


Lys Asn  Asn Gly Leu Val Thr  Lys Arg Asn Ser Glu  Asp Leu Cys 
    1160                 1165                 1170             


Asn Leu  Val Lys Val Met Leu  Glu Tyr Lys Lys Ser  
    1175                 1180                 1185 


<210>  48
<211>  1252
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  48

Met Lys Ile Thr Lys Ile Asp Asp Val Ser His Tyr Lys Lys Gln Asp 
1               5                   10                  15      


Lys Gly Val Leu Lys Ser Lys Asn Val Leu Lys Gly Glu Ile Glu Lys 
            20                  25                  30          


Ile Val Lys Lys Arg Tyr Asp Val Thr Ile Glu Ser Lys Ile Tyr Lys 
        35                  40                  45              


Glu Phe Ile Lys Leu Arg Lys Asn Arg Ile Glu Gln Asn Asn Glu Lys 
    50                  55                  60                  


Ser Ile Leu Lys Leu Ile Lys Leu Asn Ile Asp Lys Asn Glu Lys Glu 
65                  70                  75                  80  


Ile Lys Thr Leu Leu Leu Asn Lys Phe Lys Ile Lys Glu Lys Asn Lys 
                85                  90                  95      


Lys Tyr Asp Lys Tyr Met Leu Asp Glu Asn Lys Leu Asp Asn Asp Ile 
            100                 105                 110         


Lys Ile Tyr Glu Ser Val Glu Ser Leu Tyr Phe Leu Ile Lys Glu Ile 
        115                 120                 125             


Tyr Leu Gly Gln Asn Asn Lys Lys Trp Asn Ile Ser Lys Ile Asp Leu 
    130                 135                 140                 


Glu Lys Ile Met Glu Glu Asp Asn Asn Leu Ile Met Leu Gly Tyr Lys 
145                 150                 155                 160 


Leu Lys Lys Asn Ile Thr Glu Asn Asp Tyr Pro Tyr Leu Tyr Ser Asp 
                165                 170                 175     


Lys Asn Gly Gln Glu Ser Thr Ser Val Tyr Lys Leu Leu Lys Lys Leu 
            180                 185                 190         


Ile Glu Glu Asn Lys Asp Arg Asn Gln Asp Arg Asn Gln Asp Ile Arg 
        195                 200                 205             


Lys Ser Gln Glu Tyr Glu Lys Ile Arg Lys Asn Phe Glu Glu Tyr Lys 
    210                 215                 220                 


Asn Arg Lys Ile Asn Leu Leu Val Lys Ser Ile Lys Asn Asn Lys Ile 
225                 230                 235                 240 


Asn Ile Gln Tyr Ile Asn Asn Glu Ile Lys Ser His Asn Asn Ser Arg 
                245                 250                 255     


Glu Glu Asn Ile Ile Lys Phe Phe Lys Lys Met Ile Glu Glu Lys Asn 
            260                 265                 270         


Glu Pro Ile Leu Lys Asp Lys Leu Lys Leu Phe Lys Leu Glu Val Phe 
        275                 280                 285             


Phe Asp Glu Glu Phe Leu Glu Glu Ile Lys Lys Leu Leu Asp Ser Asp 
    290                 295                 300                 


Asp Phe Asp Lys Ser Tyr Asn Lys Lys Ile Ser Glu Leu Arg Gly Lys 
305                 310                 315                 320 


Ile Phe Asn Arg Ile Arg Glu Lys Ile Lys Asn Asn Lys Asn Arg Asp 
                325                 330                 335     


Glu Leu Glu Asn Ile Tyr Phe Leu Glu Leu Lys Lys Tyr Ile Glu Asn 
            340                 345                 350         


Asn Leu Ser His Lys Lys Glu Lys Asn Lys Asn Asn Asn Asn Thr Gly 
        355                 360                 365             


Glu Glu Lys Ser Lys Glu Leu Tyr Leu Lys Phe Leu Lys Lys Val Leu 
    370                 375                 380                 


Phe Ile Asp Asp Asn Asn Arg Ile Ser Ile Glu Lys Leu Lys Ser Arg 
385                 390                 395                 400 


Ile Asp Asp Asn Phe Lys Asn Leu Leu Ile Gln His Val Ile Glu Tyr 
                405                 410                 415     


Gly Lys Ile Lys Tyr Tyr Val Glu Asn Asp Asp Tyr Ile Arg Asn Ile 
            420                 425                 430         


Val Lys Asn Gly Glu Leu Lys Leu Glu Thr Lys Asp Leu Glu Tyr Ile 
        435                 440                 445             


Lys Thr Lys Glu Thr Leu Ile Arg Lys Met Ala Val Leu Val Ser Phe 
    450                 455                 460                 


Ala Ala Asn Ser Tyr Tyr Asn Leu Phe Gly Ser Val Ser Glu Asp Ile 
465                 470                 475                 480 


Leu Gly Thr Glu Val Val Lys Asn Arg Arg Thr Asn Val Ile Lys Val 
                485                 490                 495     


Lys Ser Tyr Ile Phe Lys Glu Lys Met Leu Asn Tyr Phe Phe Asp Ser 
            500                 505                 510         


Glu Asp Phe Asp Ile Asn Lys Thr Ile Glu Val Leu Glu Ser Ile Ser 
        515                 520                 525             


Tyr Ser Ile Tyr Asn Ile Arg Asn Gly Val Gly His Phe Asn Lys Leu 
    530                 535                 540                 


Val Leu Gly Lys Tyr Lys Lys Lys Asp Ile Asn Thr Asn Lys Arg Val 
545                 550                 555                 560 


Glu Glu Asp Leu Asn Asn Asn Glu Glu Ile Lys Gly Tyr Phe Ile Gln 
                565                 570                 575     


Lys Arg Gly Glu Ile Glu Lys Lys Ile Lys Glu Arg Phe Leu Ser Asn 
            580                 585                 590         


Asn Leu Gln Tyr Tyr Tyr Ala Lys Glu Arg Ile Glu Asn Tyr Phe Glu 
        595                 600                 605             


Val Tyr Glu Phe Glu Ile Leu Lys Glu Lys Ile Pro Phe Ala Pro Asn 
    610                 615                 620                 


Phe Lys Arg Ile Ile Lys Lys Gly Glu Asp Leu Phe Asn Asn Lys Lys 
625                 630                 635                 640 


Asn Lys Lys Tyr Glu Tyr Phe Lys Asn Phe Asp Lys Asn Ser Ala Glu 
                645                 650                 655     


Glu Lys Lys Glu Phe Leu Lys Thr Arg Asn Phe Leu Leu Lys Glu Leu 
            660                 665                 670         


Tyr Tyr Asn Asn Phe Tyr Lys Glu Phe Leu Ser Lys Lys Glu Glu Leu 
        675                 680                 685             


Lys Lys Ile Val Ile Glu Val Lys Glu Glu Lys Lys Asn Arg Gly Asn 
    690                 695                 700                 


Asn Lys Lys Ser Gly Val Ser Phe Gln Asn Ile Asp Asp Tyr Asp Thr 
705                 710                 715                 720 


Lys Ile Asn Ile Ser Asp Tyr Ile Ala Ser Ile His Lys Lys Glu Met 
                725                 730                 735     


Glu Arg Val Glu Lys Tyr Asn Glu Glu Lys Gln Lys Asp Thr Ala Lys 
            740                 745                 750         


Tyr Ile Arg Asp Phe Val Glu Glu Ile Phe Leu Thr Gly Phe Ile Asn 
        755                 760                 765             


Tyr Leu Glu Lys Asp Glu Arg Leu His Phe Leu Lys Glu Glu Phe Ser 
    770                 775                 780                 


Val Leu Cys Asn Ser Asn Asn Asn Val Ile Asp Phe Asn Val Asn Ile 
785                 790                 795                 800 


Asn Glu Glu Lys Ile Lys Glu Phe Leu Lys Glu Asn Asp Ser Lys Thr 
                805                 810                 815     


Leu Asn Leu Tyr Leu Phe Phe Asn Met Ile Asp Ser Lys Arg Ile Ser 
            820                 825                 830         


Glu Phe Arg Asn Glu Leu Ile Lys Tyr Lys Gln Phe Thr Lys Lys Arg 
        835                 840                 845             


Leu Asp Glu Glu Lys Glu Phe Leu Gly Ile Lys Ile Glu Leu Tyr Glu 
    850                 855                 860                 


Thr Leu Ile Glu Phe Val Ile Leu Thr Arg Glu Lys Leu Asp Thr Lys 
865                 870                 875                 880 


Lys Ser Glu Glu Thr Asp Ala Trp Leu Val Asp Lys Leu Tyr Val Lys 
                885                 890                 895     


Glu Lys Asn Glu Cys Asn Glu Tyr Glu Tyr Lys Glu Tyr Glu Glu Ile 
            900                 905                 910         


Leu Lys Leu Phe Val Asp Glu Lys Ile Leu Ile Ser Lys Glu Ala Pro 
        915                 920                 925             


Tyr Tyr Ala Thr Asn Asn Lys Thr Pro Ile Ile Leu Ser Asn Phe Glu 
    930                 935                 940                 


Lys Thr Arg Lys Tyr Gly Thr Gln Asn Leu Leu Ala Lys Ile Gln Ser 
945                 950                 955                 960 


Ser Tyr Lys Tyr Asn Glu Ile Glu Lys Gln Lys Ile Glu Asn Tyr Asn 
                965                 970                 975     


Glu Lys Lys Glu Ser Glu Lys Lys Lys Lys Ser Asn Ile Glu Lys Leu 
            980                 985                 990         


Gln Asp Leu Lys Val Glu Leu His  Lys Lys Trp Glu Gln  Asn Lys Ile 
        995                 1000                 1005             


Thr Glu  Lys Glu Ile Lys Lys  Tyr Asn Asp Thr Ile  Lys Glu Ile 
    1010                 1015                 1020             


Arg Glu  Tyr Asn Tyr Leu Lys  Asn Lys Glu Glu Leu  Gln Asn Val 
    1025                 1030                 1035             


Tyr Leu  Leu His Glu Ile Leu  Ser Asp Leu Leu Ala  Arg Asn Val 
    1040                 1045                 1050             


Ala Phe  Phe Asn Lys Trp Glu  Arg Asp Phe Lys Phe  Ile Val Ile 
    1055                 1060                 1065             


Ala Ile  Lys Gln Phe Leu Arg  Glu Asn Asp Lys Glu  Lys Val Glu 
    1070                 1075                 1080             


Asn Phe  Leu Asn Pro Pro Asp  Asn Ser Lys Gly Lys  Lys Val Tyr 
    1085                 1090                 1095             


Phe Ser  Val Ser Lys Tyr Lys  Asn Thr Val Glu Asn  Ile Asp Gly 
    1100                 1105                 1110             


Ile His  Lys Asn Phe Met Asn  Leu Ile Phe Leu Asn  Asn Lys Phe 
    1115                 1120                 1125             


Met Asn  Arg Lys Ile Asp Lys  Met Asn Cys Thr Ile  Trp Val Tyr 
    1130                 1135                 1140             


Phe Arg  Asn Tyr Ile Ala His  Phe Leu His Leu His  Thr Lys Asn 
    1145                 1150                 1155             


Glu Lys  Ile Ser Leu Ile Asn  Gln Met Asn Leu Leu  Ile Lys Leu 
    1160                 1165                 1170             


Phe Ser  Tyr Asp Lys Lys Val  Gln Asn His Ile Leu  Lys Ser Thr 
    1175                 1180                 1185             


Lys Thr  Leu Leu Glu Lys Tyr  Asn Ile Gln Ile Asn  Phe Glu Ile 
    1190                 1195                 1200             


Ser Asn  Asp Lys Asn Glu Val  Phe Lys Tyr Lys Ile  Lys Asn Arg 
    1205                 1210                 1215             


Leu Tyr  Ser Lys Lys Gly Lys  Met Leu Gly Lys Asn  Asn Lys Phe 
    1220                 1225                 1230             


Glu Ile  Leu Glu Asn Glu Phe  Leu Glu Asn Val Lys  Thr Leu Leu 
    1235                 1240                 1245             


Glu Tyr  Ser Lys 
    1250         


<210>  49
<211>  1258
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  49

Met Arg Gly Gly His Met Lys Ile Thr Lys Ile Asp Gly Ile Ser His 
1               5                   10                  15      


Tyr Lys Glu Lys Glu Lys Gly Val Leu Lys Ala Lys Asp Val Leu Leu 
            20                  25                  30          


Asn Gly Glu Ile Lys Glu Ile Val Lys Lys Arg Tyr Asp Ala Thr Ile 
        35                  40                  45              


Glu Ser Lys Ile Tyr Lys Glu Phe Ile Lys Leu Arg Lys Asn Arg Val 
    50                  55                  60                  


Glu His Asn Asn Glu Lys Ser Val Leu Glu Leu Ile Lys Ser Asn Ile 
65                  70                  75                  80  


Asp Lys Asn Glu Lys Glu Ile Lys Thr Leu Leu Leu Asp Glu Phe Lys 
                85                  90                  95      


Ile Lys Glu Lys Asn Lys Lys Tyr Asp Lys Tyr Met Ser Asp Lys Asn 
            100                 105                 110         


Glu Leu Asp Asn Asp Ile Gln Ile Tyr Glu Ser Val Glu Ser Leu Tyr 
        115                 120                 125             


Phe Phe Ile Lys Glu Val Tyr Ser Gly Lys Asn Asn Asp Lys Trp Asp 
    130                 135                 140                 


Ile Ser Lys Ile Asp Leu Glu Lys Ile Met Glu Lys Asp Asn Asn Leu 
145                 150                 155                 160 


Ile Met Leu Gly Tyr Lys Leu Lys Lys Asn Ile Lys Glu Asp Glu Tyr 
                165                 170                 175     


Pro Tyr Leu Tyr Lys Asn Glu Asn Arg Glu Lys Ser Thr Pro Leu Tyr 
            180                 185                 190         


Thr Leu Leu Lys Lys Leu Ile Glu Glu Asn Lys Asp Ser Asn Gln Asn 
        195                 200                 205             


Ile Arg Glu Ser Gln Glu Tyr Arg Lys Ile Gln Lys Asp Phe Lys Glu 
    210                 215                 220                 


Tyr Lys Asn Ile Lys Ile Asn Leu Leu Val Lys Ser Ile Leu Asn Asn 
225                 230                 235                 240 


Lys Val Asn Ile Lys Tyr Asn Thr Ser Asn Asn Asn Ile Glu Asp Ser 
                245                 250                 255     


Asn Ser Lys Arg Glu Lys Glu Ile Ile Glu Phe Phe Lys Lys Met Ile 
            260                 265                 270         


Glu Glu Lys Asn Lys Pro Ile Leu Glu Asp Arg Leu Lys Leu Phe Lys 
        275                 280                 285             


Leu Glu Val Phe Phe Asp Glu Glu Phe Leu Glu Glu Ile Lys Lys Leu 
    290                 295                 300                 


Leu Asp Ser Asp Asn Leu Asp Lys Ser Asp Asn Lys Lys Ile Ala Glu 
305                 310                 315                 320 


Leu Arg Gly Lys Ile Phe Ser Arg Ile Arg Glu Lys Ile Lys Glu Asp 
                325                 330                 335     


Lys Asn Arg Tyr Ile Leu Lys Asn Ile Tyr Phe Leu Glu Leu Lys Lys 
            340                 345                 350         


Tyr Ile Glu Asn Asn Leu Ser His Lys Lys Glu Asn Asn Lys Asn Asn 
        355                 360                 365             


Ser Asn Ile Gly Glu Glu Lys Ser Lys Glu Leu Tyr Leu Lys Phe Leu 
    370                 375                 380                 


Lys Lys Ile Leu Phe Ile Asp Asp Asn Asn Arg Ile Ser Ile Glu Lys 
385                 390                 395                 400 


Leu Lys Ser Arg Ile Asp Asp Asn Phe Lys Asn Leu Leu Ile Gln His 
                405                 410                 415     


Val Ile Glu Tyr Gly Lys Ile Lys Tyr Tyr Val Glu Asn Asp Asp Tyr 
            420                 425                 430         


Ile Lys Asn Ile Val Lys Asn Gly Glu Leu Lys Leu Glu Thr Glu Asn 
        435                 440                 445             


Leu Glu Tyr Ile Arg Ile Arg Glu Thr Leu Ile Arg Lys Met Ala Val 
    450                 455                 460                 


Leu Val Ser Phe Ala Ala Asn Ser Phe Tyr Asn Leu Phe Glu Asn Ile 
465                 470                 475                 480 


Thr Ser Asp Ile Leu Thr Ala Asn Ile Asn Leu Asp Ser Gly Val Ile 
                485                 490                 495     


Lys Ile Gly Asn Asn Arg Leu Lys Glu Lys Phe Leu Asn Tyr Phe Phe 
            500                 505                 510         


Tyr Ser Glu Glu Ile Ser Asp Lys Glu Asp Phe Leu Lys Ala Leu Lys 
        515                 520                 525             


Asp Ser Ile Tyr Asn Val Arg Asn Gly Val Asn His Phe Asp Lys Met 
    530                 535                 540                 


Ile Leu Gly Lys Tyr Asn Asn Gly Leu Asp Leu Lys Asp Ser Asp Thr 
545                 550                 555                 560 


Ile Lys Asp Tyr Phe Asn Phe Lys Lys Lys Glu Ile Gln Gln Asp Leu 
                565                 570                 575     


Lys Asp Arg Phe Ile Ser Asn Asn Leu Gln Tyr Tyr Tyr Thr Glu Asn 
            580                 585                 590         


Glu Ile Lys Lys Tyr Phe Glu Lys Tyr Lys Phe Glu Ile Leu Lys Thr 
        595                 600                 605             


Lys Ala Ser Phe Ala Pro Asn Phe Lys Arg Ile Leu Arg Lys Gly Glu 
    610                 615                 620                 


Asn Leu Ser Ile Ser Glu Ile Ser Asp Ile Tyr Asp Phe Phe Lys Arg 
625                 630                 635                 640 


Tyr Ser Glu Asn Ser Asp Lys Ser Ser Glu Tyr Asn Glu Phe Thr Lys 
                645                 650                 655     


Thr Arg Asn Phe Leu Leu Lys Glu Leu Tyr Tyr Asn Asn Phe Tyr Arg 
            660                 665                 670         


Glu Phe Leu Ser Asp Gly Thr Lys Phe Glu Glu Ala Val Lys Lys Val 
        675                 680                 685             


Lys Asn Asn Lys Lys Asn Arg Ile Ile Gly Asn Lys Lys Ser Ala Gly 
    690                 695                 700                 


Lys Ser Tyr Asp Val Ile Glu Asp Tyr Asn Ser Ser Asp Asp Val Leu 
705                 710                 715                 720 


Glu Tyr Ile Ser Arg Ile His Lys Ser Glu Met Glu Arg Ile Glu Ile 
                725                 730                 735     


Asn Thr Glu Lys Asn Arg Lys Asp Thr Ser Lys Tyr Ile Arg Asp Phe 
            740                 745                 750         


Ile Glu Glu Val Phe Leu Glu Gly Phe Ile Lys Tyr Leu Asp Asn Asn 
        755                 760                 765             


Asn Leu Asn Phe Leu Lys Asn Arg Asn Lys Ala Asp Lys Glu Arg Lys 
    770                 775                 780                 


Glu Ile Val Arg Asn Leu Asn Ile Glu Ile Glu Gly Leu Asp Ile Leu 
785                 790                 795                 800 


Asn Gln Asn Asp Ser Glu Ile Leu Asn Leu Tyr Leu Phe Phe Asn Met 
                805                 810                 815     


Ile Asp Asn Lys Arg Ile Ser Glu Phe Arg Asn Glu Met Ile Lys Tyr 
            820                 825                 830         


Lys Gln Phe Leu Thr Lys Arg Gln Asn Ile Lys Ser Lys Phe Leu Glu 
        835                 840                 845             


Ile Asp Ile Glu Lys Ile Glu Ala Ile Ile Glu Phe Val Ile Ile Thr 
    850                 855                 860                 


Arg Gly Lys Leu Glu Ile Leu Glu Gly Glu Thr Lys Glu Gln Lys Lys 
865                 870                 875                 880 


Asp Asn Met Asn Ala Leu Phe Asn Lys Phe Tyr Ser Ser Glu Ser Glu 
                885                 890                 895     


Tyr Asp Glu Ser Leu Lys Lys Phe Ile Glu Glu Thr Val Leu Asn Asp 
            900                 905                 910         


Lys Lys Asn Thr Pro Phe Tyr Ser Thr Asp Gly Lys Thr Pro Ile Val 
        915                 920                 925             


His Ser Asn Leu Glu Lys Met Arg Lys Tyr Gly Thr Glu Asn Phe Leu 
    930                 935                 940                 


Ser Lys Val Leu Lys Asp Glu Lys Tyr Thr Leu Asp Asn Met Lys Ile 
945                 950                 955                 960 


Lys Glu Lys Phe Glu Thr Glu Val Asn Asp Lys Phe Lys Glu Gln Lys 
                965                 970                 975     


Ile Leu Glu Lys Val Asp Lys Ile Lys Gly Asn Glu Lys His Lys Lys 
            980                 985                 990         


Leu Ile Glu Tyr Tyr Asn Asp Cys  Arg Cys Tyr Leu His  Lys Glu Trp 
        995                 1000                 1005             


Ile Glu  Asn Lys Lys Asn Lys  Glu Glu Phe Glu Tyr  Lys Glu Ile 
    1010                 1015                 1020             


Tyr Glu  Lys Ile Ile Glu Glu  Ile Arg Lys Tyr Asn  Tyr Leu Glu 
    1025                 1030                 1035             


Asn Lys  Glu Lys Leu Gln Asn  Val Tyr Leu Leu His  Glu Ile Thr 
    1040                 1045                 1050             


Ser Asp  Leu Met Ala Arg Asn  Val Ala Phe Ile Asn  Lys Trp Glu 
    1055                 1060                 1065             


Arg Asp  Phe Lys Phe Leu Ser  Ile Ala Ile Lys Glu  Asn Leu Lys 
    1070                 1075                 1080             


Asp Ser  Asn Asp Ile Gln Lys  Ile Glu Glu Phe Leu  Asn Pro Ser 
    1085                 1090                 1095             


Leu Asp  Ile Thr Ser Asp Glu  Glu His Phe Asn Val  Lys Asn Tyr 
    1100                 1105                 1110             


Ala Ser  Lys Leu Lys Asn Ile  Gln Gly Leu His Asn  Asn Ile Ile 
    1115                 1120                 1125             


Ser Leu  Ile Phe Ile Lys His  Leu Asp Gly Trp Ser  Asn Lys Ile 
    1130                 1135                 1140             


Asp Asn  Phe Lys Trp Leu Gly  Phe Arg Asn Tyr Ile  Ser His Phe 
    1145                 1150                 1155             


Asn His  Ile Asn Gly Glu Asn  Ser Lys Glu Ser Phe  Ile Asn Gln 
    1160                 1165                 1170             


Leu Asn  Arg Leu Val Leu Leu  Phe Ser Tyr Asp Lys  Lys Val Gln 
    1175                 1180                 1185             


Asn His  Ile Thr Lys Ser Ile  Lys Thr Ile Leu Glu  Lys Tyr Asn 
    1190                 1195                 1200             


Ile Asp  Ile Glu Phe Lys Ile  Ser Asp Asp Ser Lys  Asn Phe Phe 
    1205                 1210                 1215             


Glu Tyr  Gln Ile Ser Asn Ile  Asn Ser Lys Lys Gly  Lys Met Leu 
    1220                 1225                 1230             


Gly Lys  Glu Asn Tyr Phe Glu  Leu Leu Asp Glu Glu  Phe Val Gln 
    1235                 1240                 1245             


Asn Val  Lys Lys Met Leu Glu  Tyr Glu Asp 
    1250                 1255             


<210>  50
<211>  1425
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  50

Leu Phe Leu Trp Ile Ile Glu Glu Val Ile Tyr Glu Ile Ile Lys Leu 
1               5                   10                  15      


Tyr Lys Asn Leu Lys Glu Glu Ile Ile Met Gly Asn Leu Phe Gly Tyr 
            20                  25                  30          


Lys Lys Trp Tyr Lys Val Asp Lys Thr Ile Lys Asp Lys Lys Gly Lys 
        35                  40                  45              


Glu Ser Thr Ile Lys Gln Glu Val Arg Ile Lys Arg Asn Tyr Thr Val 
    50                  55                  60                  


Asp Arg Tyr Thr Leu Asn Thr Asn Asn Lys Glu Lys Asn Asn Ile Asn 
65                  70                  75                  80  


Asn Glu His Phe Val Asn Gln Phe Ile Glu Tyr Lys Thr Lys Asn Asp 
                85                  90                  95      


Ile Phe Glu Lys Phe Thr Arg Lys Phe His Met Gly Asn Ile Leu Phe 
            100                 105                 110         


Lys Leu Lys Gly Lys Ser Gln Lys Gly Lys Ile Ile Asn Asp Lys Asp 
        115                 120                 125             


Phe Phe Glu Thr Lys Lys Ile Val Leu Asp Lys Glu Val Tyr Gly Gln 
    130                 135                 140                 


Ser Glu Lys Leu Arg Asn Glu Lys Gly Ile Thr Lys Gln Asp Ile Leu 
145                 150                 155                 160 


Lys Glu Ile Ile Asn Lys Gly Ile Asn Glu Ser Asn Asp Lys Ile Leu 
                165                 170                 175     


Val Lys Thr Lys Phe Gly Lys Glu Ile Thr Ile Asn Phe Thr Asp Glu 
            180                 185                 190         


Asp Lys Lys Asn Lys Asn Glu Tyr Gln Ile Thr Leu Lys Ile Ile Pro 
        195                 200                 205             


Glu Asn Glu Leu Lys Ile Lys Arg Glu Val Tyr Gly Val Phe Lys Ile 
    210                 215                 220                 


Ile Asn Met Asp Leu Tyr Gln Ile Ile Lys Glu Ile Ile Lys Asn Glu 
225                 230                 235                 240 


Val Gln Lys Val Phe Gly Asn Arg Tyr Tyr Glu Glu Tyr Leu Arg Glu 
                245                 250                 255     


Lys Leu Leu Lys Asp Asp Lys Ile Gly Asp Ile Leu Thr Asn Phe Met 
            260                 265                 270         


Glu Ile Arg Lys Lys Thr Lys Ser Asn Leu Glu Ile Met Gly Phe Val 
        275                 280                 285             


Lys Phe Tyr Leu Asn Val Gly Gly Asp Lys Lys Lys Ser Glu Asn Lys 
    290                 295                 300                 


Lys Ile Phe Val Glu Lys Ile Leu Asn Ile Asn Val Asp Leu Thr Val 
305                 310                 315                 320 


Glu Asp Ile Val Asp Phe Ile Val Lys Glu Leu Lys Phe Trp Asn Ile 
                325                 330                 335     


Thr Lys Arg Ile Glu Lys Leu Gln Glu Lys Thr Val Asn Arg Ala Asp 
            340                 345                 350         


Glu Asp Ile Lys Asn Thr Tyr Val Asn Thr Tyr Val Leu Leu Asp Lys 
        355                 360                 365             


His Glu Lys Phe Lys Lys Tyr Asn Arg Asn Lys Lys Asp Thr Ile Val 
    370                 375                 380                 


Lys Ser Phe Ile Lys Asp Ile Lys Asp Asn Thr Met Lys Gln Lys Ile 
385                 390                 395                 400 


Asn Gln Ile Leu Arg Lys Phe Lys Ile Glu Glu Leu Ile Glu Lys Leu 
                405                 410                 415     


Arg Ile Glu Asn Lys Asn Phe Asp Thr Glu Ile Phe Arg Ile Phe Lys 
            420                 425                 430         


Asp His Tyr Gln Glu Met Phe Ser Ser Glu Lys Phe Glu Glu Lys Ser 
        435                 440                 445             


Asp Glu Glu Lys Glu Leu Tyr Lys Ile Ile Tyr Arg Tyr Leu Lys Gly 
    450                 455                 460                 


Arg Ile Glu Lys Ile Leu Ile Asn Glu Gln Lys Val Arg Leu Lys Lys 
465                 470                 475                 480 


Met Glu Lys Ile Glu Val Glu Lys Ile Leu Asn Glu Ser Val Leu Ser 
                485                 490                 495     


Glu Lys Ile Leu Lys Arg Val Lys Gln Tyr Thr Leu Glu His Ile Met 
            500                 505                 510         


Tyr Leu Gly Lys Leu Val His Asn Asn Ile Asp Met Thr Thr Val Asn 
        515                 520                 525             


Thr Asn Asp Phe Ser Arg Leu His Ala Lys Glu Glu Leu Asp Leu Glu 
    530                 535                 540                 


Leu Ile Thr Phe Phe Ala Ser Thr Asn Met Glu Leu Asn Lys Ile Phe 
545                 550                 555                 560 


Ser Arg Glu Asn Ile Asn Asn Asp Glu Asn Ile Asp Phe Phe Gly Gly 
                565                 570                 575     


Asp Arg Glu Lys Asn Tyr Val Leu Asp Lys Lys Asn Leu Asn Ser Lys 
            580                 585                 590         


Ile Glu Ile Ile Arg Asp Leu Asp Phe Ile Asp Asn Lys Asn Asn Ile 
        595                 600                 605             


Thr Asn Asn Phe Ile Ser Lys Phe Thr Lys Ile Gly Thr Asn Glu Arg 
    610                 615                 620                 


Asn Arg Ile Leu His Ala Ser Ser Lys Glu Arg Asp Leu Gln Gly Thr 
625                 630                 635                 640 


Gln Asp Asp Tyr Asn Lys Val Ile Asn Ile Ile Gln Asn Leu Lys Ile 
                645                 650                 655     


Ser Asp Glu Glu Val Ser Lys Ala Leu Asn Leu Asp Val Val Phe Lys 
            660                 665                 670         


Asp Lys Lys Asn Ile Ile Thr Lys Ile Asn Asp Ile Glu Ile Ser Glu 
        675                 680                 685             


Glu Asn Asn Ser Val Ile Lys Tyr Leu Pro Ser Phe Ser Lys Val Leu 
    690                 695                 700                 


Pro Glu Ile Leu Asn Leu Tyr Lys Asn Lys Asn Lys Asn Asn Pro Phe 
705                 710                 715                 720 


Asp Thr Thr Glu Thr Glu Arg Ile Met Leu Asn Ala Leu Ile Tyr Val 
                725                 730                 735     


Asn Lys Glu Leu Tyr Lys Lys Leu Ile Leu Glu Lys Asn Leu Glu Glu 
            740                 745                 750         


Asn Glu Ser Lys Asn Lys Phe Leu Lys Glu Leu Lys Lys Asn Leu Gly 
        755                 760                 765             


Gly Thr Asp Glu Ile Asp Glu Asn Ile Ile Glu Ser Tyr Tyr Lys Asn 
    770                 775                 780                 


Thr Gln Ile Ser Ala Ser Lys Gly Asn Asn Lys Ala Ile Lys Lys Tyr 
785                 790                 795                 800 


Gln Lys Lys Ile Ile Glu Cys Tyr Ile Lys Tyr Leu Glu Glu Asn Tyr 
                805                 810                 815     


Arg Glu Leu Phe Asp Phe Ser Asp Phe Lys Met Asn Ile Gln Glu Ile 
            820                 825                 830         


Lys Lys Gln Ile Lys Glu Ile Asn Asp Asn Lys Thr Tyr Lys Arg Ile 
        835                 840                 845             


Thr Ile Lys Thr Ser Asp Lys Ser Ile Val Ile Asn Asn Asp Phe Glu 
    850                 855                 860                 


Tyr Ile Ile Ser Ile Phe Ala Leu Leu Asn Asn Asn Ile Phe Ile Asn 
865                 870                 875                 880 


Lys Ile Arg Asn Arg Phe Phe Ala Thr Ser Val Trp Leu Asn Thr Ser 
                885                 890                 895     


Glu Tyr Gln Asn Ile Ile Asp Ile Leu Asp Glu Ile Met Gln Leu Asn 
            900                 905                 910         


Thr Leu Arg Asn Glu Cys Ile Thr Glu Asn Trp Asn Leu Asn Leu Glu 
        915                 920                 925             


Glu Phe Ile Gln Lys Met Lys Glu Ile Glu Lys Asp Phe Asp Asp Phe 
    930                 935                 940                 


Lys Ile Gln Thr Lys Lys Glu Ile Phe Asn Asn Tyr Tyr Glu Asp Ile 
945                 950                 955                 960 


Lys Asn Asn Ile Leu Thr Glu Phe Lys Asp Asp Ile Asn Gly Cys Asp 
                965                 970                 975     


Val Leu Glu Lys Lys Leu Glu Lys Ile Val Ile Phe Asp Asp Glu Thr 
            980                 985                 990         


Lys Phe Glu Ile Asp Lys Lys Ser  Asn Ile Leu Gln Asp  Glu Gln Arg 
        995                 1000                 1005             


Lys Leu  Ser Asn Ile Asn Lys  Lys Asp Leu Lys Lys  Lys Val Asp 
    1010                 1015                 1020             


Gln Tyr  Ile Lys Asp Lys Asp  Gln Glu Ile Lys Ser  Lys Ile Leu 
    1025                 1030                 1035             


Cys Arg  Ile Ile Phe Asn Ser  Asp Phe Leu Lys Lys  Tyr Lys Lys 
    1040                 1045                 1050             


Glu Ile  Asp Asn Leu Val Glu  Ser Thr Glu Ser Lys  Asn Glu Asn 
    1055                 1060                 1065             


Lys Phe  Glu Lys Ile Tyr Tyr  Pro Glu Glu His Lys  Asn Glu Leu 
    1070                 1075                 1080             


Tyr Ile  Tyr Lys Lys Asn Leu  Phe Leu Asn Ile Gly  Asn Pro Asn 
    1085                 1090                 1095             


Phe Asp  Lys Ile Tyr Gly Leu  Ile Ser Lys Asp Ile  Lys Ile Thr 
    1100                 1105                 1110             


Asp Ala  Lys Phe Leu Phe Asn  Ser Asp Gly Lys Asn  Ile Arg Asn 
    1115                 1120                 1125             


Asn Lys  Ile Ala Glu Ile Asp  Val Ile Leu Lys Lys  Leu Asn Asn 
    1130                 1135                 1140             


Lys Leu  Asn Gly Tyr Ser Lys  Glu Tyr Lys Glu Lys  Tyr Ile Glu 
    1145                 1150                 1155             


Lys Leu  Lys Glu Asn Asn Asp  Phe Phe Ala Lys Asn  Ile Gln Asn 
    1160                 1165                 1170             


Glu Asn  Tyr Asn Ser Phe Glu  Glu Phe Lys Glu Asp  Tyr Asn Lys 
    1175                 1180                 1185             


Val Ser  Glu Tyr Lys Lys Ile  Arg Asp Leu Val Glu  Phe Asn Tyr 
    1190                 1195                 1200             


Leu Asn  Lys Ile Glu Ser Tyr  Leu Ile Asp Ile Asn  Trp Lys Leu 
    1205                 1210                 1215             


Ala Ile  Gln Met Ala Arg Phe  Glu Arg Asp Met His  Tyr Ile Val 
    1220                 1225                 1230             


Asn Gly  Leu Lys Lys Leu Asn  Phe Ile Asn Leu Asn  Gly Tyr Asn 
    1235                 1240                 1245             


Thr Gly  Ile Ser Arg Thr Tyr  Pro Lys Tyr Asn Asp  Ser Asp Ser 
    1250                 1255                 1260             


Asn Lys  Asn Cys Lys Lys Phe  Tyr Glu Thr Thr Ala  Tyr Tyr Lys 
    1265                 1270                 1275             


Phe Phe  Asp Asp Lys Ser Tyr  Arg Glu Phe Glu Asp  Ile Cys Tyr 
    1280                 1285                 1290             


Glu Phe  Gly Ile Asp Leu Arg  Lys Asn Ser Asn Ile  Gln Ala Lys 
    1295                 1300                 1305             


Glu Glu  Arg Asn Ile Arg Asn  Tyr Ile Ser His Phe  Tyr Ile Val 
    1310                 1315                 1320             


Arg Asn  Pro Phe Ala Asp Tyr  Ser Ile Ala Glu Gln  Ile Asp Arg 
    1325                 1330                 1335             


Val Ser  Asn Leu Leu Ser Tyr  Ser Thr Arg Tyr Asn  Asn Ser Thr 
    1340                 1345                 1350             


Tyr Ala  Ser Val Phe Glu Val  Phe Lys Lys Asp Val  Asp Leu Asp 
    1355                 1360                 1365             


Tyr Asp  Glu Leu Lys Lys Lys  Phe Lys Leu Ile Gly  Asn Asn Asp 
    1370                 1375                 1380             


Ile Leu  Glu Arg Leu Met Lys  Pro Lys Lys Val Ser  Val Leu Glu 
    1385                 1390                 1395             


Leu Glu  Ser Tyr Asn Ser Asn  Tyr Val Lys Asn Leu  Ile Ile Lys 
    1400                 1405                 1410             


Leu Leu  Thr Lys Ile Glu Lys  Thr Asn Asp Thr Leu  
    1415                 1420                 1425 


<210>  51
<211>  1172
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  51

Met Gly Ser Gly Lys Tyr Arg Ile Thr Lys Ile Ala Arg Glu Trp Lys 
1               5                   10                  15      


Glu Asn Lys Lys Lys Ile Ala Leu Lys Arg Ile Val Arg Lys Gly Glu 
            20                  25                  30          


Ile Lys Tyr Ile Asp Glu Asn Asn Asp Glu Asn Ile Asp Ile Thr Asp 
        35                  40                  45              


Ala Tyr Tyr Lys Ile Leu Ser Ser Asn Arg Phe Pro Gly Thr Lys Glu 
    50                  55                  60                  


Gln Phe Ile Phe Lys Val Asn Lys Met Glu Arg Asn Ile Glu Asn Asp 
65                  70                  75                  80  


Cys Val Ile Ile Lys Asn Tyr Thr Glu Glu Glu Tyr Glu Lys Phe Lys 
                85                  90                  95      


Glu Asn Asn Asn Lys Ile Phe Ile Lys Ser Ile Ala Val Lys Glu His 
            100                 105                 110         


Gly Lys Glu Met Asn Lys Asn Lys Ile Cys Arg Pro Phe Tyr Glu Lys 
        115                 120                 125             


Glu Lys Glu Ile Met Ser Lys Arg Met Lys Glu Ser Gln Lys Phe Asn 
    130                 135                 140                 


Asn Ile Val Tyr Asn Ile Cys Lys Lys Ile Tyr Tyr Leu Lys Tyr Gly 
145                 150                 155                 160 


Asp Asn Ser Asp Arg Lys Ile Tyr Glu Ile Phe Gln Asn Glu Ile Lys 
                165                 170                 175     


Val Lys Asp Val Lys Asn Leu Lys Glu Ala Phe Lys Gln Gln Glu Lys 
            180                 185                 190         


Gly Leu Glu Thr Asp Lys Leu Leu Ala Ile Ser Phe Asn Lys Lys Arg 
        195                 200                 205             


Asn Asn Val Leu Leu Glu Phe Ile Gln Gln Ile Thr Lys Gln Glu Phe 
    210                 215                 220                 


Lys Asn Gln Lys Glu Leu Glu Asn Trp Phe Ser Gln Ser Gly Glu Lys 
225                 230                 235                 240 


Tyr Cys Lys Glu Ile Phe Lys Ile Tyr Ser Asn Met Ser Gln Lys Glu 
                245                 250                 255     


Lys Tyr Phe Lys Leu Leu Gly His Arg Asn Gln Gly Ile Ala Ser Ile 
            260                 265                 270         


Tyr Asp Glu Lys Lys Glu Thr Leu Gln Arg Arg Leu Lys Ile Gly Asn 
        275                 280                 285             


Tyr Ser Asp Tyr Asp Leu Lys Lys Tyr Tyr Gln Lys Asp Tyr Lys Glu 
    290                 295                 300                 


Glu Ala Ile Lys Glu Leu Lys Asp Lys Asn Lys Glu Gly Leu Glu Arg 
305                 310                 315                 320 


Glu Ile Glu Glu Leu Ile Lys Lys Asn Tyr Lys Ile Asp Lys Leu Cys 
                325                 330                 335     


Asp Glu Ile Ser Asn Leu Glu Phe Ser Phe Val Glu Ser Lys Lys Glu 
            340                 345                 350         


Asn Lys Asp Lys Met Ser Glu Ile Ile Val Lys Ile Lys Glu His Tyr 
        355                 360                 365             


Lys Lys Asn Val Asn Val Glu Lys Glu Leu Lys Asn Lys Glu Lys Tyr 
    370                 375                 380                 


Ile Leu Ser Leu Ile His Asn Tyr Val Lys Gly Arg Tyr Arg Lys Cys 
385                 390                 395                 400 


Leu Glu Leu Gln Gln Lys Glu Asn Val Asp Phe Lys Asn Leu Gly Lys 
                405                 410                 415     


Arg Ile Lys Glu Ile Phe Asp Ser Asn Glu Val Thr Lys Lys Leu Glu 
            420                 425                 430         


Lys Ser Ile Ile Asn Lys Val Asn Ser Tyr Lys Ile Phe Glu Met Lys 
        435                 440                 445             


Phe Gln Asn Pro Asn Ile Glu Ser Ser Asp Asp Leu Glu Ile Leu Lys 
    450                 455                 460                 


Ala Glu Glu Thr Phe Leu Asn Lys Leu Ser Thr Ala Val Ser Lys Val 
465                 470                 475                 480 


Gly Tyr Thr Leu Asn Ile Leu Leu Glu Val Ser Ser Glu Lys Asp Ile 
                485                 490                 495     


Leu Glu Asn Tyr Asn Met Val Gly Glu Leu Cys Asn Asn Asn Ser Thr 
            500                 505                 510         


Thr Glu Ile Tyr Lys Val Tyr Pro Glu Leu Glu Lys Asn Glu Lys Leu 
        515                 520                 525             


Leu Gln Gly Met Ile His Phe Ile Gln Gly Leu Arg Gln Gln Ser Leu 
    530                 535                 540                 


His Pro Lys Ile Leu Trp Asn Phe Glu Thr Lys Asn Leu Lys Pro Glu 
545                 550                 555                 560 


Lys Leu Glu Arg Leu Lys Glu Lys Lys Ser Ile Lys Met Arg Asp Cys 
                565                 570                 575     


Val Val His Glu Asp Ser Leu Asp Lys Lys Glu Lys Asn Glu Val Glu 
            580                 585                 590         


Ile Lys Lys Tyr Phe Glu Lys Ile Glu Glu Lys Leu Pro Asp Tyr Phe 
        595                 600                 605             


Ile Glu Lys Tyr Glu Ser Asn Asn Val Phe Asn Ile Tyr Arg Asn Phe 
    610                 615                 620                 


Ile Asp Lys Val Met Glu Val Val Lys Asn Phe Asn Phe Lys Glu Asn 
625                 630                 635                 640 


Asn Thr Ile Asp Tyr Leu Phe Pro Lys Phe His Lys Ile Tyr Lys Arg 
                645                 650                 655     


Met Cys Asn Ser Glu Asn Ile Asp Asp Arg Gln Asn Gly Ala Arg Lys 
            660                 665                 670         


Tyr Leu Leu Gln Thr Ile Tyr Tyr Tyr Tyr Phe Gln Tyr Glu Ile Glu 
        675                 680                 685             


Asn Asp Lys Asn Asn Met Ser Lys Tyr Leu Asn Leu Tyr Arg Asn Lys 
    690                 695                 700                 


Ile Lys Val Lys Lys Ile Ser Tyr Ser Tyr Ile Thr Asp Asn Lys Ala 
705                 710                 715                 720 


Val Asn Asn Lys Asn Ile Glu Ile Leu Tyr Arg Asn Ile Gln Arg Glu 
                725                 730                 735     


Gly Met Leu Asn Asn Arg Leu Leu Gln Met Asn Asn Glu Trp Ile Glu 
            740                 745                 750         


Phe Ile Val Val Gln Phe Ser Glu Phe Leu Thr Asn Lys Lys Leu Asn 
        755                 760                 765             


Trp Ile Leu Asp Asp Leu Ser Glu Tyr Lys Lys Lys Glu Lys Leu Asp 
    770                 775                 780                 


Glu Asn Asn Lys Asn Lys Leu Leu Lys Ile Leu Lys Gln Lys Met Asn 
785                 790                 795                 800 


Lys Lys Ile Thr Tyr Ser Asn Asp Ser Tyr Val Phe Ile Ser Leu Thr 
                805                 810                 815     


Gln Phe Leu Asp Leu Lys Glu Ile Ser Asn Leu Ile His Asp Ile Lys 
            820                 825                 830         


Lys Phe Ile Gln Phe Arg Glu Lys Asn Val Ser Lys Tyr Lys Pro Glu 
        835                 840                 845             


Lys Asn Lys Leu Tyr Ile Glu Glu Leu Arg Lys Ile Leu Tyr Ile Ser 
    850                 855                 860                 


Lys Val Val Leu Glu His Lys Glu Arg Val Met Gln Lys His Tyr Leu 
865                 870                 875                 880 


Glu Ser Tyr Asp Glu Asp Ile Ser Ile Met Tyr Gly Lys Gly Ile Glu 
                885                 890                 895     


Lys Lys Asp Ile Lys Asp Ile Glu Ile Lys Ile Lys Asn Lys Asn Gln 
            900                 905                 910         


Glu Val Ile Asn Gln Pro Leu Tyr Lys Ser Gly Asn Asp Glu Asn Asn 
        915                 920                 925             


Ser Trp Ile Ile Leu Tyr Gly Ile Glu Gln Ala Lys Arg Asn Gly Thr 
    930                 935                 940                 


Phe Lys Phe Phe Glu Gly Phe Phe Asn Leu Asn Asp Asp Ile Lys Leu 
945                 950                 955                 960 


Cys Lys Glu Asp Ile Glu Lys Tyr Glu Lys Leu Tyr Asn Glu Lys Glu 
                965                 970                 975     


Glu Asn Gln Lys Lys Val Asp Glu Tyr Ile Ser Lys Leu Asn Asn Asp 
            980                 985                 990         


Ile Glu Lys Ile Asn Asn Asp Asn  Asn Asp Ile Asn Ile  Glu Lys Thr 
        995                 1000                 1005             


Asn Asn  Asn Lys Gln Leu Phe  Tyr Tyr Tyr Lys Asn  Met Ile Tyr 
    1010                 1015                 1020             


Gly Asp  Gly Leu Lys Lys Gly  Tyr Asp Phe Ile Asn  Asp Ile Tyr 
    1025                 1030                 1035             


Ser His  Tyr Leu Ser Trp Ala  Tyr Arg Ile Glu Arg  Asp Tyr Ser 
    1040                 1045                 1050             


Ile Tyr  Lys Val Glu Glu Tyr  Asn Gly Lys Ile Lys  Asn Phe Arg 
    1055                 1060                 1065             


Asn Glu  Val Ala His Phe Asn  Tyr Phe Gln Lys Thr  Asp Lys Ser 
    1070                 1075                 1080             


Leu Leu  Asp Leu Leu Asn Asp  Phe Tyr Ser Ile Phe  Asp Tyr Asn 
    1085                 1090                 1095             


Leu Lys  Tyr Gln Arg Asp Val  Gln Lys Val Ile Asn  Asn Ile Phe 
    1100                 1105                 1110             


Glu Lys  Tyr Gln Val Ile Arg  Glu Asp Gly Gly Pro  Val Ile Phe 
    1115                 1120                 1125             


Tyr Cys  Lys Ile Asp Lys Lys  Leu Lys Leu Ser Glu  Asn Ile Ile 
    1130                 1135                 1140             


Pro Lys  Lys His Ser Lys Tyr  Pro Glu Ile Lys Leu  Ile His Glu 
    1145                 1150                 1155             


Lys Tyr  Val Glu Phe Phe Lys  Lys Leu Phe Glu Tyr  Lys Lys 
    1160                 1165                 1170         


<210>  52
<211>  1107
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  52

Met Arg Val Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Val Tyr Ser Gly 
            20                  25                  30          


Gln Ala Ile Ser Asn Glu Thr Asn Asn Ile Leu Pro Glu Lys Lys Arg 
        35                  40                  45              


Gln Ser Phe Asp Leu Ser Ile Glu Asn Lys Thr Leu Lys Arg Arg Asp 
    50                  55                  60                  


Asp Val Asp Lys Thr Lys Lys Asp Lys Tyr Asp Ile Val Arg Lys Ile 
65                  70                  75                  80  


Ile Lys Tyr Gly Glu Leu Pro Gln Ser Ile Ser Glu Val Asp Val Leu 
                85                  90                  95      


Glu Phe Leu Asn His Lys Phe Gln Glu Pro Val Lys Tyr Trp Lys Gly 
            100                 105                 110         


Asp Lys Glu Glu Ser Phe Asn Leu Thr Met Leu Ile Leu Glu Ala Val 
        115                 120                 125             


Lys Thr Gln Asp Lys Gln Lys Leu Gln Pro Tyr Asn Glu Trp Lys Lys 
    130                 135                 140                 


Trp Tyr Val Thr Thr Lys Ser Asp Leu Leu Lys Lys Ser Ile Asp Asn 
145                 150                 155                 160 


Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg Lys Lys Ala Leu 
                165                 170                 175     


Leu Ala Trp Glu Thr Glu Phe Thr Thr Ser Gly Asn Ile Asp Leu Thr 
            180                 185                 190         


His Tyr His Lys Val Tyr Met Thr Asp Val Leu Cys Lys Met Leu Gln 
        195                 200                 205             


Glu Val Lys Pro Leu Thr Asp Glu Arg Gly Arg Ile Asn Ser Asn Ala 
    210                 215                 220                 


Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Asn His Gln Pro Ala Met 
225                 230                 235                 240 


Phe Gly Thr Arg Glu Ala Pro Asn Asp Ala Asn Arg Ala Asp Asn Gln 
                245                 250                 255     


Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu Glu His Tyr Phe 
            260                 265                 270         


Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Thr Asp Asp Ile Ser His 
        275                 280                 285             


Tyr Leu Lys Ala Gln Thr Leu Lys Thr Thr Ile Glu Lys Gln Leu Val 
    290                 295                 300                 


Asn Ala Ile Arg Ser Asn Ile Ile Gln Gln Gly Lys Thr Asn His His 
305                 310                 315                 320 


Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile Arg Ile Lys Thr 
                325                 330                 335     


Asn Glu Ala Phe Val Leu Asn Leu Ile Gly Thr Cys Ala Phe Ala Ala 
            340                 345                 350         


Asn Asn Ile Arg Asn Met Val Asp Asn Glu Gln Thr Ser Asp Ile Leu 
        355                 360                 365             


Gly Lys Gly Asp Phe Ser Lys Ser Leu Leu Lys Asp Ser Ala Ser Thr 
    370                 375                 380                 


Gln Leu Tyr Ser Phe Phe Phe Glu Glu Asn Leu Ser Thr Asn Lys Val 
385                 390                 395                 400 


Glu Lys Glu Thr Gln Leu Trp Ala Ile Arg Gly Ala Val Gln Gln Ile 
                405                 410                 415     


Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu Lys Thr Val Phe 
            420                 425                 430         


Asn Ile Ser Asn Phe Glu Asn Pro Thr Thr Thr Asp Pro Lys Gln Gln 
        435                 440                 445             


Thr Asn Tyr Ala Asp Thr Ile Tyr Lys Ala Arg Phe Ile Asn Glu Leu 
    450                 455                 460                 


Glu Lys Ile Pro Glu Ala Phe Ala Gln Gln Leu Lys Thr Gly Gly Ala 
465                 470                 475                 480 


Leu Ser Tyr Tyr Thr Leu Glu Asn Leu Lys Thr Leu Leu Thr Thr Phe 
                485                 490                 495     


Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala Pro Gly Phe Lys 
            500                 505                 510         


Lys Val Phe Asn Gly Gly Ile Asn Tyr Gln Asn Ala Lys Gln Asp Glu 
        515                 520                 525             


Ser Phe Tyr Glu Leu Met Leu Glu Arg Tyr Leu Arg Lys Glu Asn Phe 
    530                 535                 540                 


Ala Glu Glu Ala Tyr Asn Ala Arg Tyr Phe Leu Leu Lys Leu Ile Tyr 
545                 550                 555                 560 


Asn Asn Leu Phe Leu Pro Lys Phe Thr Thr Tyr Arg Lys Ala Phe Ala 
                565                 570                 575     


Asp Ser Val Gly Phe Val Gln Leu Gln Asn Arg Lys Gln Ala Glu Lys 
            580                 585                 590         


Val Asn Pro Lys Lys Lys Glu Ala Tyr Ala Phe Glu Ala Val Arg Pro 
        595                 600                 605             


Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala Tyr Val Gln Ser 
    610                 615                 620                 


Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys Ala Thr Asp Glu 
625                 630                 635                 640 


Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val Phe Ile Lys Gly 
                645                 650                 655     


Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe Val Gln Val Pro 
            660                 665                 670         


Gln Gln Gln Leu Thr Thr Thr Asp Ser Asn Gln Gln Lys Ala Asp Lys 
        675                 680                 685             


Leu Asn Gly Leu Glu Ala Ser Ile Thr Ala Asp Cys Lys Leu Thr Pro 
    690                 695                 700                 


Gln Tyr Ala Lys Ala Asp Asp Ala Thr His Ile Ala Phe Tyr Val Phe 
705                 710                 715                 720 


Cys Lys Leu Leu Asp Ala Ala His Leu Ser Asn Leu Arg Asn Glu Leu 
                725                 730                 735     


Ile Lys Phe Arg Gly Ser Val Asn Glu Phe Lys Phe His His Leu Leu 
            740                 745                 750         


Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val Val Pro Thr Asp 
        755                 760                 765             


Tyr Arg Asp Leu Tyr Thr Asn Glu Ala Asp Cys Leu Ala Arg Leu Ser 
    770                 775                 780                 


Pro Phe Ile Glu Gln Gly Ala Asp Ile Lys Asn Trp Ser Asp Leu Tyr 
785                 790                 795                 800 


Val Gln Thr Asp Lys Gln Thr Pro Val Val His Ala Gly Ile Glu Leu 
                805                 810                 815     


Ser Val Lys Tyr Gly Thr Thr Ala Leu Leu Glu Gln Leu Ile Ala Arg 
            820                 825                 830         


Asn Pro Lys Phe Arg Ile Met Glu Asp Asn Phe Thr Lys Trp Ser Asn 
        835                 840                 845             


Gln Lys Lys Glu Ile Glu Glu Lys Val Asn Ile His Thr Lys Leu His 
    850                 855                 860                 


Lys Glu Trp Val Glu Ala Lys Glu Lys Asp Asp Lys Glu Arg Thr Asp 
865                 870                 875                 880 


Arg Val Lys Ser Lys Thr Asn Phe Ala Arg Lys Phe Val Ser Lys Asn 
                885                 890                 895     


Glu Val Asp Tyr Ile Asn Asn Cys Ile Glu Ile Asn Asn Tyr Asn Trp 
            900                 905                 910         


Leu Asp Asn Lys Leu His Phe Val His Leu Asn His Leu His His Leu 
        915                 920                 925             


Thr Ile Glu Ile Leu Gly Arg Met Ala Gly Phe Val Ala Leu Trp Glu 
    930                 935                 940                 


Arg Asp Phe Gln Tyr Ile Thr Lys Tyr Thr Ala Ala Lys Glu Gly Thr 
945                 950                 955                 960 


Asp Ala Leu Ser Phe Asp Gly Gly Leu Pro Arg Leu Lys Asp Lys Gln 
                965                 970                 975     


Lys Tyr Tyr Asp Lys Leu Phe Leu Ser Asp Lys Tyr Thr Lys Val Arg 
            980                 985                 990         


Asn His Ile Ala His Phe Asn Tyr  Leu Thr Lys Asp Ala  Ala Asp Phe 
        995                 1000                 1005             


Ser Leu  Ile Asp Leu Ile Asn  Glu Leu Arg Glu Leu  Leu His Tyr 
    1010                 1015                 1020             


Asp Arg  Lys Leu Lys Asn Ala  Val Ser Lys Ala Phe  Ile Lys Leu 
    1025                 1030                 1035             


Phe Glu  Lys His Gly Met Ile  Leu Lys Leu Lys Leu  Asn Asp Gly 
    1040                 1045                 1050             


His Gln  Leu Glu Leu Glu Ser  Ile Glu Pro Lys Lys  Ile Tyr His 
    1055                 1060                 1065             


Leu Gly  Ser Ser Ala Lys Asp  Lys Pro Glu Tyr Gln  Tyr Cys Thr 
    1070                 1075                 1080             


Asn Gln  Val Met Thr Ala Tyr  Cys Asn Met Cys Arg  Ser Leu Leu 
    1085                 1090                 1095             


Glu Met  Lys Lys Glu Gln Ile  Gly Leu 
    1100                 1105         


<210>  53
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  53

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Ile Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Phe Asp Phe Lys Leu  Leu Asn 
    1400                 1405                 1410         


<210>  54
<211>  1425
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  54

Met Lys Leu Ser Lys Val Asp Arg Ile Arg Val Ala Val Gly Lys Thr 
1               5                   10                  15      


Gly Lys Thr Glu Asn Gly Asn Ser Gln Gly Arg Gly Val Leu Tyr Arg 
            20                  25                  30          


Ser Pro Lys Gly Asn Lys Thr Val Ala Val Asp Ala Val Val Glu Glu 
        35                  40                  45              


Arg Ile Arg Asn Ala Asn Arg Leu Tyr Ser Ala Phe Phe Arg Cys Ala 
    50                  55                  60                  


Tyr Pro Glu Glu Pro Glu Arg His Phe Glu Glu Ile Ile Lys Arg Met 
65                  70                  75                  80  


Ala Thr Gly Lys Lys Ser Gly Ala Gln Ile Leu Lys Glu Tyr Ile Gly 
                85                  90                  95      


Tyr Glu Gly Gln Lys Asn Arg Lys Pro Tyr Thr Phe Tyr Val Asn Lys 
            100                 105                 110         


Cys Ala Tyr Arg Pro Ala Gly Lys Glu Leu Gly Gln Val Leu Arg Leu 
        115                 120                 125             


Phe Val Lys Glu Arg Leu Gly Gln Asn Trp Gln Asn Pro Glu Ala Ala 
    130                 135                 140                 


Glu Ala Ala Val Ala Leu Leu Thr Cys Leu Cys Glu Gly Lys Thr Asn 
145                 150                 155                 160 


Arg Tyr Thr Glu Asn Thr Ala Asp Gly Pro Val Leu Thr Glu Leu Ser 
                165                 170                 175     


Glu Gln Thr Val Thr Gln Leu Glu Gln Val Ser Arg Leu Gly Gly Ser 
            180                 185                 190         


Ile Leu Val Pro Lys Thr Glu Arg Leu Glu Thr Ile Val Thr Val Ile 
        195                 200                 205             


Leu Arg Leu Thr Ala Glu Gln Cys Asn Thr Ser Leu Tyr Val Asn Gly 
    210                 215                 220                 


Gly Thr Lys Glu Ala Gln Asp Ala Asp Leu Glu Lys Gln Ile Ala Leu 
225                 230                 235                 240 


Leu Lys Ser Leu Gln Thr Lys Pro Leu Leu Leu Lys Glu Arg Phe Asp 
                245                 250                 255     


Lys Val Thr Lys Gln Thr Ile Arg Asp Glu Gln Lys Leu Ser Glu Phe 
            260                 265                 270         


Ser Tyr Lys Asp Ala Thr Lys Glu Arg Met Glu Ala Val Val Val Arg 
        275                 280                 285             


Met Arg Lys Thr Leu Lys Lys Gly Ala Ser Arg Glu Val Ala Val Glu 
    290                 295                 300                 


Leu Leu Gln Ala Leu Ala Gln Tyr Asp Gly Lys Thr Trp Asp Gly Trp 
305                 310                 315                 320 


Leu Thr Gln Met Leu Glu Thr Glu Ala Ser Lys Lys Lys Leu Lys Asp 
                325                 330                 335     


Phe Ile Leu Ala Val Asn Lys Asp Phe His His Phe His Val Ile Lys 
            340                 345                 350         


Ser Val Lys Asn Thr Ala Val Ala Val Ser His Ser Glu Asp Asn Thr 
        355                 360                 365             


Leu Gln Leu Ser Gly Ala Lys Lys Lys Thr Lys Gly Ala Met Gln Asp 
    370                 375                 380                 


Ala Leu Phe Ala Tyr Ala Gln Ser Glu Glu Ser Ser Asp Glu Thr Leu 
385                 390                 395                 400 


His Arg Ile Lys Arg Ile Leu Phe Thr Tyr Val Leu Gly Gly Arg Gln 
                405                 410                 415     


Asp Asn Thr Leu Arg Leu Thr Glu Lys Thr His Leu Ala Lys Glu Leu 
            420                 425                 430         


Leu Trp Lys Phe Arg Gly Thr Gly Ala Gly Leu Phe Asp Ala Asp Phe 
        435                 440                 445             


Val Pro Glu Glu Glu Arg Ala Gly Glu Ser Gly Arg Lys Ala Gly Ser 
    450                 455                 460                 


Tyr Thr Asp Leu Gly Cys Leu Phe Ala Glu Asp Asp Gly Ile Arg Asn 
465                 470                 475                 480 


Gln Arg Arg Ile Ala Asp Arg Ile Asn Tyr Val Asn Tyr Gly Asn Tyr 
                485                 490                 495     


Leu Arg Met Arg Lys Ala Ala Glu Asp Glu Phe Thr Leu Phe Trp Cys 
            500                 505                 510         


Ala Tyr Ile Lys Asp Tyr Ile Glu Glu Asn Tyr Val Thr Lys Ile Arg 
        515                 520                 525             


Glu Ala Lys Arg Thr Gly Gly Lys Arg Arg Leu Lys Glu Thr Asp Cys 
    530                 535                 540                 


Glu Ala Glu Arg Met Met Glu Lys Cys Trp His Asp Ile Ile Arg Tyr 
545                 550                 555                 560 


Ile Cys Gly Lys Tyr Ile His Ile Gly Lys Ala Val Tyr His Phe Ala 
                565                 570                 575     


Ile Pro Glu Asp Leu Leu Ala Asn Pro Gly Glu Val Arg Ser Phe Gly 
            580                 585                 590         


Asp Val His Ala Lys Tyr Ala Asp Gly Ile Thr Ser Phe Asp Tyr Glu 
        595                 600                 605             


Asp Ile Lys Ala Glu Glu Asn Leu Gln Lys Ser Ile Phe Asn Val Leu 
    610                 615                 620                 


Val Ser Ala Val Ala Asn Tyr Ser Arg Ser Val Val Asp Leu Ser Ser 
625                 630                 635                 640 


Glu Arg Ala Glu Glu Leu Arg Arg Leu Pro Gly Asn Glu Arg Leu Asn 
                645                 650                 655     


Glu Asp Val Leu Met Met Lys Glu Thr His Leu Lys Glu Leu Leu Leu 
            660                 665                 670         


Pro Asp Ala Lys Lys Arg Leu Leu Arg Tyr Phe Gly Gly Tyr Ser Ala 
        675                 680                 685             


Cys Glu Gly Leu Ser Gly Val Thr Ser Glu Glu Leu Ala Trp Glu Met 
    690                 695                 700                 


Arg Thr Val Leu Ser Thr Leu Arg Asn Glu Ser Phe His Tyr Thr Phe 
705                 710                 715                 720 


Gly Lys Lys Lys Lys Leu Asp Tyr Lys Val Ala Lys Gln Leu Trp Met 
                725                 730                 735     


Gln Ala Ile Arg Ala Asn Arg Gln Leu Ile Leu Asp Lys Tyr Tyr Ser 
            740                 745                 750         


Asn Asn Thr Cys Arg Tyr Tyr Ser Pro Asn Ser Ile Lys Ala Leu Ile 
        755                 760                 765             


Glu Gln Gly Tyr Arg Ser Tyr Glu Glu Arg Glu Ala Gln Ile Pro Ala 
    770                 775                 780                 


Phe Lys Thr Val Trp Lys Lys Ala Glu Leu Ala Lys Tyr Leu Ala Asp 
785                 790                 795                 800 


Lys Lys Val Met Pro Ala Glu Ile Ser Gly Glu Glu Lys Glu Arg Val 
                805                 810                 815     


Ile Phe Gln Gly Ala Phe Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg 
            820                 825                 830         


Glu Phe Thr Val Gly Asn Thr Ala Ala Lys Tyr Phe Phe Asp Ala Val 
        835                 840                 845             


Glu Arg Tyr Cys Lys Glu Asn Glu Thr Gly Pro Tyr Lys Asn Pro Ala 
    850                 855                 860                 


Lys Ser Phe Asn Asp Tyr Val Asn Gly Ala Phe Asn Asn Lys Gly Val 
865                 870                 875                 880 


Lys Val Gln Lys Gly Leu Ser Asp Leu Tyr Arg Glu Gly Lys Ile Thr 
                885                 890                 895     


Phe Gly Val Val Cys Gln Thr Ile Met Ala Glu Tyr Thr Gln Gln Asn 
            900                 905                 910         


Glu Lys Ser Glu Gly Glu Ala Ile Tyr Gln His Phe Lys Met Leu Phe 
        915                 920                 925             


Pro Leu Cys Met Arg Lys Gly Phe Gln Lys Tyr Val Glu Glu Lys His 
    930                 935                 940                 


Lys Glu Leu Leu Gln Pro Val Ile Arg Glu Met Gly Ser Arg Glu Asp 
945                 950                 955                 960 


Phe Leu Thr Asn Ile His Ile Gly Cys Phe Asp Asp Phe Cys Arg Glu 
                965                 970                 975     


Asp Gly Met Tyr Glu Tyr Asp Trp Phe Val Val Ala His Leu Ile His 
            980                 985                 990         


Pro Lys Arg Leu Asn Glu Leu Val  Gly Asn Leu Lys Asp  Tyr Met Gln 
        995                 1000                 1005             


Phe Lys  Gln Asp Ile Leu Arg  Arg Ala Asp Tyr Val  Glu Gln Phe 
    1010                 1015                 1020             


Thr Lys  Glu Glu Leu Ala Ala  Met Lys Ala Arg Thr  Glu Glu Lys 
    1025                 1030                 1035             


Leu Gln  Lys Ile Ser Gly Ile  Leu Arg Val Ala Glu  Phe Val Arg 
    1040                 1045                 1050             


Gly Ile  Ala Gly Arg Val Ser  Asn Thr Phe Ser Asp  Tyr Tyr Glu 
    1055                 1060                 1065             


Ser Glu  Glu Ala Tyr Ala Ser  Tyr Leu Glu Gln Tyr  Ile Glu Phe 
    1070                 1075                 1080             


Pro Arg  Ile Lys Gly Ser Thr  Val Phe Glu Ser Phe  Arg Asp Phe 
    1085                 1090                 1095             


Cys Val  Asn Thr Leu Pro Gly  Gly Ala Val Met Asp  Val Tyr Met 
    1100                 1105                 1110             


Asp Glu  Lys Asn Pro Arg Ile  Leu Arg Asn Val Glu  Val Ala Arg 
    1115                 1120                 1125             


Met Tyr  Ala Gly Gly Asp Ile  Gly Leu Arg Thr Arg  Lys Lys Val 
    1130                 1135                 1140             


Thr Ala  Glu Glu Leu Lys Arg  Tyr Tyr Gln Asn Glu  Ala Glu Val 
    1145                 1150                 1155             


Ala Ala  Leu Leu Lys Ala Gly  Leu Cys Ala Thr Ala  Glu Asp Gln 
    1160                 1165                 1170             


Lys Arg  Val Lys Ala Gln Gln  Glu Leu Arg Asn Arg  Ile Thr Leu 
    1175                 1180                 1185             


Thr Asp  Val Thr Glu Ile Gln  Glu Val Ile Asn Asp  Leu Leu Ser 
    1190                 1195                 1200             


Gln Leu  Val Thr Phe Ser Tyr  Phe Arg Glu Arg Asp  Glu Met Tyr 
    1205                 1210                 1215             


Leu Leu  Leu Gly Phe Tyr Tyr  Met Ala Leu Gln Ser  Asp Gly Asp 
    1220                 1225                 1230             


Trp Gly  Glu Glu Leu Arg Val  Phe Asp Gly Lys Lys  Leu Gln Val 
    1235                 1240                 1245             


Glu Asn  Gly Phe Val Leu Tyr  Gln Leu Leu Ser Ala  Phe Thr Tyr 
    1250                 1255                 1260             


Gly Leu  Asn Met Tyr Ser Glu  Ala Ala Pro Asp Gly  Lys Gly Gly 
    1265                 1270                 1275             


Ser Gln  Ala Gly Lys Ile Gly  Glu Phe Ile Lys Ala  His Pro Asn 
    1280                 1285                 1290             


Ser Trp  Asp Arg Ala Leu Arg  Leu Phe Val Asp Asp  Gly Ala Cys 
    1295                 1300                 1305             


Glu Glu  Val Ser Arg Lys Ala  Arg Asn Tyr Val Asp  His Phe Arg 
    1310                 1315                 1320             


Tyr Tyr  Val Lys Pro Asp Arg  Ser Ile Met Asp Leu  Tyr Ala Val 
    1325                 1330                 1335             


Tyr His  Glu Tyr Phe Phe Asp  Tyr Ser Thr Lys Met  Arg Lys Ser 
    1340                 1345                 1350             


Val Leu  Gln Asn Phe Ala Ser  Ile Leu Glu Arg Tyr  Phe Val Leu 
    1355                 1360                 1365             


Thr Lys  Phe Lys Leu Gly Gly  Glu Arg Gly Ala Gln  Thr Leu Glu 
    1370                 1375                 1380             


Ala Glu  Leu Ser Gly Asp Lys  Phe Thr Tyr Lys Leu  Ser Asp Thr 
    1385                 1390                 1395             


Lys Ala  Lys Pro Val Val Leu  Pro Ala Arg Asn Lys  Glu Phe Leu 
    1400                 1405                 1410             


Glu Asn  Leu Lys Asn Glu Leu  Asn Tyr Arg Gln Glu  
    1415                 1420                 1425 


<210>  55
<211>  1169
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  55

Met Gly Ser Gly Lys Tyr Arg Ile Thr Lys Ile Ala Arg Asp Trp Asp 
1               5                   10                  15      


Glu Asn Lys Lys Arg Ile Ile Leu Lys Arg Ile Val Ser Asp Gly Glu 
            20                  25                  30          


Val Lys Tyr Val Asn Glu Asn Asn Asn Val Asp Ile Asp Ile Thr Glu 
        35                  40                  45              


Thr Tyr Tyr Arg Ile Leu Ser Asn Asn Lys Ala Lys Phe Leu Gly Ser 
    50                  55                  60                  


Asn Glu Gln Phe Ile Phe Lys Val Asn Lys Met Lys Arg Asn Ile Lys 
65                  70                  75                  80  


Asn Asp Cys Val Ile Ile Lys Asp Tyr Thr Glu Glu Glu Phe Glu Lys 
                85                  90                  95      


Leu Asp Lys Lys Ile Phe Phe Ser Arg Lys Ile Lys Val Asn Asn Lys 
            100                 105                 110         


Asp Arg Glu Lys Ile Cys Arg Asn Phe Tyr Glu Asp Glu Arg Glu Ile 
        115                 120                 125             


Met Lys Lys Arg Leu Glu Glu Ala Lys Lys Phe Asn Asn Ile Ile Phe 
    130                 135                 140                 


Asn Ile Cys Asn Lys Ile Phe Lys Leu Glu Tyr Leu Asp Tyr Thr Asp 
145                 150                 155                 160 


Glu Lys Val Tyr Lys Ile Phe Gln Asn Glu Ile Lys Val Lys Asp Val 
                165                 170                 175     


Lys Asn Leu Lys Glu Ala Phe Lys Gln Gln Glu Lys Gly Leu Glu Thr 
            180                 185                 190         


Asp Lys Leu Leu Ala Ile Ser Phe Asn Lys Lys Arg Asn Asn Ile Leu 
        195                 200                 205             


Leu Glu Phe Ile Gln Gln Ile Ala Lys Gln Glu Phe Glu Asn Gln Lys 
    210                 215                 220                 


Glu Leu Glu Asn Trp Phe Ser Tyr Gly Gly Glu Lys Tyr Cys Lys Glu 
225                 230                 235                 240 


Ile Phe Lys Ile Tyr Ser Asn Met Ser Gln Lys Glu Lys Tyr Phe Lys 
                245                 250                 255     


Leu Leu Gly His Arg Asn Gln Gly Ile Ala Ser Ile Tyr Asp Glu Lys 
            260                 265                 270         


Lys Glu Thr Leu Gln Arg Arg Leu Lys Leu Gly Asp Tyr Ser Lys Tyr 
        275                 280                 285             


Asp Leu Lys Arg Tyr Tyr Gln Lys Asp Tyr Lys Glu Glu Ala Ile Lys 
    290                 295                 300                 


Glu Leu Lys Asp Lys Asn Lys Glu Gly Leu Glu Arg Glu Ile Glu Glu 
305                 310                 315                 320 


Leu Ile Lys Lys Asn Tyr Lys Ile Asp Lys Leu Cys Asp Glu Ile Ser 
                325                 330                 335     


Asn Leu Glu Phe Ser Phe Val Glu Ser Lys Lys Glu Asn Lys Asp Lys 
            340                 345                 350         


Met Ser Glu Ile Ile Val Lys Ile Lys Glu His Tyr Lys Lys Asn Val 
        355                 360                 365             


Asn Val Glu Glu Glu Leu Glu Asn Lys Glu Lys Tyr Ile Leu Ser Ile 
    370                 375                 380                 


Ile His Asn Tyr Val Lys Gly Arg Tyr Arg Lys Cys Leu Glu Leu Gln 
385                 390                 395                 400 


Gln Lys Glu Asn Val Asp Phe Glu Asn Leu Glu Lys Arg Ile Lys Glu 
                405                 410                 415     


Ile Phe Asp Ser Asn Glu Val Thr Lys Lys Leu Lys Lys Ser Ile Ile 
            420                 425                 430         


Asn Lys Val Asn Ser Tyr Lys Ile Phe Glu Met Lys Phe Gln Asn Pro 
        435                 440                 445             


Asn Val Glu Ser Ser Asp Asp Leu Glu Ile Leu Lys Ala Glu Glu Thr 
    450                 455                 460                 


Phe Leu Asn Lys Leu Ser Thr Ala Val Ser Lys Val Gly Tyr Ile Leu 
465                 470                 475                 480 


Asn Ile Leu Leu Glu Ile His Phe Arg Asn Asp Ile Leu Gln Asp Tyr 
                485                 490                 495     


Asn Gln Val Glu Lys Leu Trp Lys Ser Asp Ser Phe Gln Lys Ile Cys 
            500                 505                 510         


Ala Ile Tyr Pro Glu Ile Asn Asn Asp Glu Lys Leu Leu Lys Gly Met 
        515                 520                 525             


Ile Tyr Phe Ile Gln Gly Leu Arg Gln Gln Val Leu His Pro Lys Ile 
    530                 535                 540                 


Leu Trp Glu Lys Gln Asn Ile Tyr Asn Ala Glu Asn Ile Lys Glu Lys 
545                 550                 555                 560 


Glu Lys Ile Val Ser Val Lys Leu Gln Asn Glu Gly Glu Ala Tyr Asn 
                565                 570                 575     


Lys Lys Gly Ile Gln Asn Tyr Phe Glu Asn Val Leu Lys Lys Ile Pro 
            580                 585                 590         


Asp Tyr Phe Ile Glu Lys Tyr Glu Ser Asn Asn Val Phe Asn Ile Tyr 
        595                 600                 605             


Arg Asn Ser Val Asp Lys Ile Met Glu Val Val Lys Asn Phe Asn Phe 
    610                 615                 620                 


Lys Glu Asn Asn Thr Ile Asp Tyr Leu Phe Pro Lys Phe His Lys Ile 
625                 630                 635                 640 


Tyr Lys Arg Met Cys Lys Ser Glu Asn Ile Asp Asp Arg Gln Asn Gly 
                645                 650                 655     


Ala Arg Lys Tyr Leu Leu Gln Thr Ile Tyr Tyr Tyr Tyr Phe Gln Tyr 
            660                 665                 670         


Glu Ile Glu Asn Asp Lys Asn Asn Met Ser Lys Tyr Leu Asn Leu Tyr 
        675                 680                 685             


Arg Asn Lys Ile Lys Val Lys Lys Ile Ser Tyr Ser Tyr Ile Ile Asp 
    690                 695                 700                 


Asn Lys Ala Val Asn Asn Lys Asn Ile Glu Ile Leu Tyr Arg Asn Ile 
705                 710                 715                 720 


Gln Arg Glu Gly Met Leu Asn Asn Arg Leu Leu Gln Met Asn Asn Glu 
                725                 730                 735     


Trp Ile Glu Phe Ile Val Val Gln Phe Ser Glu Phe Leu Thr Lys Lys 
            740                 745                 750         


Lys Leu Asn Trp Ile Leu Asp Asp Leu Ser Glu Tyr Lys Lys Lys Glu 
        755                 760                 765             


Lys Leu Asp Glu Asn Asp Lys Asn Glu Leu Leu Lys Ile Phe Lys Gln 
    770                 775                 780                 


Lys Met Asn Lys Asn Ile Thr Tyr Ser Asn Asp Ser Tyr Ala Phe Ile 
785                 790                 795                 800 


Ser Leu Ala Gln Phe Leu Asp Leu Lys Glu Ile Ser Asn Leu Ile His 
                805                 810                 815     


Asp Ile Lys Lys Phe Val Gln Phe Arg Glu Lys Asn Ile Leu Lys Tyr 
            820                 825                 830         


Asn Pro Glu Lys Asn Lys Ile Tyr Ile Glu Glu Leu Arg Lys Ile Leu 
        835                 840                 845             


Tyr Ile Leu Lys Val Met Leu Glu His Lys Glu Arg Val Ile Gln Lys 
    850                 855                 860                 


His Tyr Leu Gly Ser Tyr Asp Glu Asp Ile Ser Ile Met Tyr Gly Lys 
865                 870                 875                 880 


Asp Ile Glu Lys Lys Asp Ile Lys Asp Ile Glu Ile Lys Ile Lys Asn 
                885                 890                 895     


Lys Asn Gln Glu Val Ile Asn Gln Pro Leu Tyr Lys Ser Gly Asn Asp 
            900                 905                 910         


Glu Asn Ser Ser Trp Ile Ile Leu Tyr Gly Ile Glu Gln Ala Lys Arg 
        915                 920                 925             


Asn Gly Thr Phe Lys Phe Phe Glu Gly Phe Phe Asn Leu Asn Asp Asp 
    930                 935                 940                 


Ile Lys Leu Cys Lys Glu Asp Ile Glu Lys Tyr Glu Lys Leu Tyr Asn 
945                 950                 955                 960 


Glu Lys Glu Glu Asn Gln Lys Lys Val Asp Glu Tyr Ile Ser Lys Leu 
                965                 970                 975     


Asn Asn Asp Ile Glu Lys Ile Asn Asn Asp Ile Asn Ile Glu Lys Thr 
            980                 985                 990         


Asn Asp Asn Lys Gln Leu Phe Tyr  Tyr Tyr Lys Asn Met  Ile Tyr Gly 
        995                 1000                 1005             


Asp Gly  Leu Lys Lys Gly Tyr  Asp Phe Ile Asn Asp  Ile Tyr Ser 
    1010                 1015                 1020             


His Tyr  Leu Ser Trp Ala Tyr  Arg Ile Glu Arg Asp  Cys Lys Ile 
    1025                 1030                 1035             


Tyr Lys  Ile Lys Glu Tyr Glu  Asn Lys Lys Asn Phe  Asn Glu Tyr 
    1040                 1045                 1050             


Lys Phe  Lys Glu Tyr Lys Ser  Ile Lys Tyr Phe Arg  Asn Glu Ile 
    1055                 1060                 1065             


Ala His  Phe Asn Tyr Phe Gln  Lys Thr Asn Lys Ser  Leu Leu Glu 
    1070                 1075                 1080             


Leu Leu  Asn Asn Phe Tyr Asp  Ile Phe Asp Tyr Asn  Leu Lys Tyr 
    1085                 1090                 1095             


Gln Arg  Asp Val Gln Lys Val  Ile Asn Asn Ile Phe  Glu Lys Tyr 
    1100                 1105                 1110             


Gln Val  Ile Arg Glu Asp Gly  Gly Pro Val Ile Phe  Tyr Cys Lys 
    1115                 1120                 1125             


Ile Asp  Lys Lys Leu Lys Leu  Ser Glu Asn Ile Ile  Pro Lys Lys 
    1130                 1135                 1140             


His Leu  Lys Cys Ser Lys Ile  Lys Leu Ile His Glu  Lys Tyr Val 
    1145                 1150                 1155             


Glu Phe  Phe Arg Lys Leu Phe  Glu Tyr Lys Lys 
    1160                 1165                 


<210>  56
<211>  1148
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  56

Met Lys Val Thr Lys Ile Asp Gly Ile Ser His Lys Lys Tyr Glu Glu 
1               5                   10                  15      


Lys Gly Lys Leu Val Lys Ile Asn Asn Glu Lys Lys Asp Ile Thr Glu 
            20                  25                  30          


Glu Arg Phe Asn Asp Ile Glu Val Lys Thr Met Glu Leu Phe Gln Lys 
        35                  40                  45              


Thr Leu Asp Phe Tyr Val Lys Asn Tyr Glu Lys Cys Glu Glu Gln Asn 
    50                  55                  60                  


Lys Glu Arg Arg Glu Lys Ala Lys Asn Tyr Phe Ser Lys Val Lys Leu 
65                  70                  75                  80  


Ile Val Asp Asn Lys Lys Ile Lys Ile Cys Asn Glu Asn Pro Glu Lys 
                85                  90                  95      


Met Glu Ile Glu Asp Phe Asn Glu Tyr Asp Val Arg Asn Arg Lys Tyr 
            100                 105                 110         


Phe Asn Ile Leu Asn Lys Ile Leu Asn Glu Glu Asn Arg Thr Glu Glu 
        115                 120                 125             


Asp Leu Glu Val Phe Glu Asn Asp Leu Gln Lys Lys Leu Asn Gln Ile 
    130                 135                 140                 


Gln Ser Ile Lys Asn Ser Leu Glu Glu Asn Lys Ala His Phe Lys Lys 
145                 150                 155                 160 


Glu Ser Ile Asn Asn Thr Thr Asp Arg Val Lys Gly Asn Asn Lys Lys 
                165                 170                 175     


Ser Leu Phe Tyr Glu Tyr Tyr Arg Asn Ser Ser Lys His Gln Glu Tyr 
            180                 185                 190         


Val Asn Asn Ile Phe Glu Ala Phe Asp Lys Leu Tyr Ser Asn Ser His 
        195                 200                 205             


Glu Asp Ile Asn Asn Leu Phe Leu Glu Ile Thr Lys Asp Ser Asn Asp 
    210                 215                 220                 


Arg Asn Ile Arg Lys Ile Arg Glu Ala Tyr His Glu Ile Leu Asn Lys 
225                 230                 235                 240 


Asn Lys Thr Glu Phe Gly Glu Glu Leu Tyr Lys Lys Ile Gln Asp Asn 
                245                 250                 255     


Ile Ser Asn Phe Asp Lys Leu Leu Glu Ile Glu Pro Glu Ile Lys Glu 
            260                 265                 270         


Leu Thr Lys Ser Gln Ile Phe Tyr Lys Tyr Tyr Ile Asp Lys Val Ser 
        275                 280                 285             


Leu Asp Gly Thr Asn Val Lys His Cys Phe Ser His Leu Val Glu Ile 
    290                 295                 300                 


Glu Val Asn Gln Leu Leu Lys Asn Tyr Val Tyr Ser Lys Arg Ser Thr 
305                 310                 315                 320 


Asn Lys Glu Lys Leu Glu Asn Ile Phe Glu Tyr Cys Lys Leu Arg Asn 
                325                 330                 335     


Leu Val Lys Asn Lys Leu Val Asn Lys Leu Asn Ser Tyr Ile Arg Asn 
            340                 345                 350         


Cys Gly Lys Tyr Asn Ser Tyr Ile Asn Asn Asn Asp Val Val Asn Ser 
        355                 360                 365             


Glu Lys Ile Ser Glu Ile Arg Thr Lys Glu Ala Phe Leu Arg Ser Ile 
    370                 375                 380                 


Ile Gly Val Ser Ser Ser Ala Tyr Phe Ser Leu Arg Asn Ile Leu Asn 
385                 390                 395                 400 


Thr Asp Asn Thr Gln Asp Ile Thr Asn Lys Val Asp Lys Glu Val Asp 
                405                 410                 415     


Lys Leu Tyr Gln Glu Asn Lys Lys Ile Glu Leu Glu Glu Arg Leu Lys 
            420                 425                 430         


Leu Phe Phe Gly Asn Tyr Phe Asp Ile Asn Asn Gln Gln Glu Ile Glu 
        435                 440                 445             


Asp Phe Leu Met Asn Ile Asp Lys Ile Ile Ser Ser Ile Arg His Glu 
    450                 455                 460                 


Ile Ile His Phe Lys Met Glu Ala Asn Ala Gln Asn Ile Phe Asp Phe 
465                 470                 475                 480 


Asn Asn Ile Asn Leu Gly Asn Thr Ala Lys Asn Ile Phe Asn Asn Glu 
                485                 490                 495     


Ile Asn Glu Glu Lys Ile Lys Phe Lys Ile Phe Lys Gln Leu Asn Ser 
            500                 505                 510         


Ala Asn Val Phe Asp Tyr Leu Ser Asn Lys Asp Ile Thr Glu Tyr Met 
        515                 520                 525             


Asp Lys Val Val Phe Ser Phe Thr Asn Arg Asn Val Ser Phe Val Pro 
    530                 535                 540                 


Ser Phe Thr Lys Ile Tyr Asn Arg Val Gln Asp Leu Ala Asn Ser Leu 
545                 550                 555                 560 


Glu Ile Lys Glu Trp Lys Ile Pro Asp Glu Ser Glu Gly Lys Asp Ala 
                565                 570                 575     


Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Lys Phe Leu Asp Lys 
            580                 585                 590         


Phe Leu Asn Glu Glu Asn Gly Ile Phe Ile Ser Ile Lys Asp Lys Ile 
        595                 600                 605             


Ile Glu Leu Asn Arg Asn Gln Asn Lys Arg Thr Gly Phe Tyr Lys Leu 
    610                 615                 620                 


Glu Lys Phe Glu Lys Ile Glu Glu Thr Asn Pro Lys Lys Tyr Leu Glu 
625                 630                 635                 640 


Ile Ile Gln Ser Leu Tyr Met Ile Asn Ile Glu Glu Ile Asp Ser Glu 
                645                 650                 655     


Gly Lys Asn Ile Phe Leu Asp Phe Ile Gln Lys Ile Phe Leu Lys Gly 
            660                 665                 670         


Phe Phe Glu Phe Ile Lys Asn Asp Tyr Asn Tyr Leu Leu Glu Leu Lys 
        675                 680                 685             


Lys Val Gln Asp Lys Lys Asn Ile Phe Asp Ser Lys Met Ser Glu Tyr 
    690                 695                 700                 


Ile Ala Gly Glu Lys Thr Leu Glu Asp Met Glu Glu Ile Asn Glu Ile 
705                 710                 715                 720 


Ile Gln Asp Ile Lys Ile Thr Glu Ile Asp Lys Ile Leu Asn Gln Thr 
                725                 730                 735     


Asp Arg Ile Asn Cys Phe Tyr Leu Leu Leu Lys Leu Leu Asn Tyr Lys 
            740                 745                 750         


Glu Ile Thr Glu Leu Lys Gly Asn Leu Glu Lys Tyr Gln Ile Leu Ser 
        755                 760                 765             


Lys Thr Asn Ile Tyr Glu Lys Glu Leu Met Leu Leu Asn Ile Val Asn 
    770                 775                 780                 


Leu Asp Asn Asn Lys Val Lys Ile Glu Asn Phe Lys Ile Ser Ala Glu 
785                 790                 795                 800 


Glu Ile Gly Lys Phe Ile Glu Lys Ile Asn Ile Glu Glu Ile Asn Lys 
                805                 810                 815     


Lys Ile Lys Thr Phe Glu Glu Leu Arg Asn Phe Glu Lys Gly Glu Asn 
            820                 825                 830         


Thr Gly Glu Tyr Tyr Asn Ile Tyr Ser Asp Asp Lys Asn Ile Lys Asn 
        835                 840                 845             


Ile Arg Asn Leu Tyr Asn Ile Lys Lys Tyr Gly Met Leu Asp Leu Leu 
    850                 855                 860                 


Glu Lys Ile Ser Glu Lys Thr Asn Tyr Cys Ile Lys Lys Lys Asp Leu 
865                 870                 875                 880 


Glu Glu Tyr Ser Lys Leu Arg Lys Gln Leu Glu Asp Lys Lys Lys Glu 
                885                 890                 895     


Asn Glu Lys Ile Glu Asp Glu Lys Thr Asn Phe Tyr Lys Ile Gln Glu 
            900                 905                 910         


Tyr Leu His Ser Lys Tyr Gln Gln Glu Pro Lys Lys Ile Leu Trp Lys 
        915                 920                 925             


Asn Asn Lys Asn Asp Tyr Glu Lys Tyr Lys Lys Ser Ile Glu Asn Ile 
    930                 935                 940                 


Glu Lys Tyr Val His Leu Lys Asn Lys Ile Glu Phe Asn Glu Leu Asn 
945                 950                 955                 960 


Leu Leu Gln Ser Leu Leu Leu Lys Ile Leu His Arg Leu Val Gly Phe 
                965                 970                 975     


Thr Ser Ile Trp Glu Arg Asp Leu Arg Phe Arg Leu Ile Gly Glu Phe 
            980                 985                 990         


Pro Asp Glu Leu Asp Val Glu Asp  Ile Phe Asp His Arg  Lys Arg Tyr 
        995                 1000                 1005             


Lys Gly  Thr Gly Lys Gly Ile  Cys Lys Lys Tyr Asp  Arg Phe Ile 
    1010                 1015                 1020             


Asn Thr  His Thr Glu Tyr Lys  Asn Asn Asn Lys Met  Glu Asn Val 
    1025                 1030                 1035             


Lys Phe  Ala Asp Asn Asn Pro  Val Arg Asn Tyr Ile  Ala His Phe 
    1040                 1045                 1050             


Asn Tyr  Leu Pro Thr Pro Lys  Tyr Ser Ile Leu Lys  Met Ile Glu 
    1055                 1060                 1065             


Lys Leu  Arg Lys Leu Leu Asp  Tyr Asp Arg Lys Leu  Lys Asn Ala 
    1070                 1075                 1080             


Val Met  Lys Ser Ile Lys Asp  Ile Leu Glu Glu Tyr  Gly Phe Lys 
    1085                 1090                 1095             


Ala Glu  Phe Ile Ile Asn Ser  Asp Lys Glu Ile Ile  Leu Asn Ser 
    1100                 1105                 1110             


Val Lys  Ser Val Glu Ile Ile  His Leu Gly Lys Glu  Asp Leu Lys 
    1115                 1120                 1125             


Ser His  Arg Asn Ser Glu Asp  Leu Cys Lys Leu Val  Lys Ala Met 
    1130                 1135                 1140             


Leu Glu  Tyr Ser Lys 
    1145             


<210>  57
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  57

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Asn Glu Lys Asn Thr Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Ser Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Asn Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Glu 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Val Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Thr Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Lys  Glu Leu Cys 
    1130                 1135                 1140             


Glu Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Glu  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  58
<211>  1186
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  58

Met Lys Val Thr Lys Ile Asp Gly Leu Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ile Glu Asp Ala Ser Gln Lys Asn Glu Thr 
            20                  25                  30          


Leu Glu Arg Leu Glu Lys Leu Lys Glu Ile Lys Leu Gly Asn Tyr Ile 
        35                  40                  45              


Lys Asn Pro Asp Lys Thr Lys Asp Lys Asp Asn Lys Lys Arg Arg Lys 
    50                  55                  60                  


Gly Leu Lys Glu Tyr Phe Ser Glu Ile Thr Leu Arg Lys Glu Asn Glu 
65                  70                  75                  80  


Lys Tyr Val Leu Leu Lys Gly Lys Lys Leu Lys Lys Ile Asn Asn Asp 
                85                  90                  95      


Ile Lys Asp Thr Asp Ile Lys Val Lys Tyr Lys Lys Glu Glu Val Phe 
            100                 105                 110         


Asp Val Leu Lys Lys Ile Leu Lys Leu Asn Leu Leu Ala Asn Asp Val 
        115                 120                 125             


Glu Glu Lys Ile Gln Phe Asp Ser Ile Lys Leu Lys Asn Val Phe Gly 
    130                 135                 140                 


Lys Asp Phe Val Lys Lys Glu Leu Gln Ile Lys Ser Ile Glu Glu Ser 
145                 150                 155                 160 


Leu Glu Lys Asn Lys Ala Asp Tyr Arg Lys Glu Phe Ile Glu Ile Glu 
                165                 170                 175     


Asn Asp Lys Tyr Gly Asn Val Lys Gly Glu Asn Lys Lys Asn Arg Ile 
            180                 185                 190         


Tyr Glu Tyr Tyr Lys Lys Ser Glu Thr His Glu Lys Phe Arg Lys Asn 
        195                 200                 205             


Ile Ile Glu Ala Phe Glu Lys Leu Tyr Lys Lys Asp Asp Ile Glu Lys 
    210                 215                 220                 


Leu Tyr Thr Gln Ile Ile Glu Ile Ser Lys Lys Met His Leu Lys Ser 
225                 230                 235                 240 


Lys Val Arg Glu Leu Tyr Lys Asn Val Ile Ile Lys Arg Ser Cys Asp 
                245                 250                 255     


Asp Phe Ser Lys Lys Asn Lys Glu Gly Ile Ser Val Leu Tyr Ser Gln 
            260                 265                 270         


Ile Met Asn Ser Val Lys Lys Asn Glu Lys Phe Val Lys Phe Val Lys 
        275                 280                 285             


Asn Ile Glu Leu Lys Asp Leu Thr Lys Ser Gln Ile Phe Tyr Lys Tyr 
    290                 295                 300                 


Phe Leu Glu Asn Glu Glu Leu Asn Asp Glu Asn Ile Lys Asn Ile Phe 
305                 310                 315                 320 


Cys Tyr Phe Val Glu Ile Glu Val Ser Asp Leu Leu Lys Gly Asn Val 
                325                 330                 335     


Tyr Lys Val Ser Lys Ile Tyr Glu Asn Lys Ile Lys Asn Ile Phe Glu 
            340                 345                 350         


Tyr Asn Lys Leu Lys Lys Leu Val Ile Asn Lys Leu Glu Asn Lys Leu 
        355                 360                 365             


Asn Asn Tyr Val Arg Asn Cys Gly Lys Tyr Asn Tyr His Met Glu Asn 
    370                 375                 380                 


Gly Asp Ile Ala Thr Ser Asp Ile Asn Met Arg Asn Arg Gln Thr Glu 
385                 390                 395                 400 


Ala Phe Leu Arg Ser Met Ile Gly Val Ser Ser Phe Gly Tyr Phe Ser 
                405                 410                 415     


Leu Arg Asn Ile Leu Gly Val Asn Asp Asp Asp Phe Tyr Glu Ile Glu 
            420                 425                 430         


Glu Asp Leu Thr Glu Glu Glu Arg Lys Asn Glu Ser Asn Val Leu Lys 
        435                 440                 445             


Lys Ala Lys Glu Asp Ile Thr Ser Lys Ser Ile Phe Glu Lys Val Val 
    450                 455                 460                 


Asp Lys Ser Phe Glu Lys Lys Gly Ile His Ser Ile Arg Glu Asn Val 
465                 470                 475                 480 


Lys Met Phe Tyr Gly Asp Ser Phe Asp Lys Ala Asn Glu Asp Glu Leu 
                485                 490                 495     


Lys Gln Phe Phe Val Asn Met Leu Asn Ala Ile Thr Ser Ile Arg His 
            500                 505                 510         


Arg Val Val His Tyr Asn Met Asn Thr Asn Ser Glu Asn Ile Phe Asn 
        515                 520                 525             


Phe Ser Asp Ile Glu Val Ser Arg Leu Leu Lys Ser Ile Phe Glu Lys 
    530                 535                 540                 


Glu Thr Asp Lys Arg Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn 
545                 550                 555                 560 


Ser Ala Gly Val Phe Asp Tyr Trp Glu Asn Trp Lys Ile Lys Lys Tyr 
                565                 570                 575     


Leu Glu Asn Met Lys Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val 
            580                 585                 590         


Pro Ser Phe Thr Lys Leu Tyr Asn Arg Ile Asp Asn Leu Lys Gly Ser 
        595                 600                 605             


Asn Ala Leu Asn Leu Gly Tyr Ile Asn Ile Pro Lys Arg Lys Glu Ala 
    610                 615                 620                 


Arg Asp Ser Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Lys Phe 
625                 630                 635                 640 


Val Glu Glu Phe Ile Lys Asn Asn Asp Asn Phe Glu Lys Ile Phe Arg 
                645                 650                 655     


Glu Ile Ile Glu Ile Asn Lys Asn Ala Gly Thr Asn Lys Gln Thr Asn 
            660                 665                 670         


Phe Tyr Lys Leu Glu Lys Phe Glu Lys Leu Lys Ala Asn Thr Pro Thr 
        675                 680                 685             


Glu Tyr Leu Glu Lys Leu Gln Ser Leu His Lys Ile Asn Tyr Asn Arg 
    690                 695                 700                 


Glu Lys Ile Glu Glu Asp Lys Asp Ile Tyr Val Asp Phe Val Gln Lys 
705                 710                 715                 720 


Ile Phe Leu Lys Gly Phe Ile Ser Tyr Leu Gln Lys Ser Asn Ser Leu 
                725                 730                 735     


Lys Pro Leu Asn Leu Leu Asn Leu Lys Lys Asp Glu Val Ile Asn Ser 
            740                 745                 750         


Glu Lys Ser Phe Tyr Asp Glu Lys Leu Lys Gln Trp Glu Asn Asn Gly 
        755                 760                 765             


Ser Asn Leu Ser Glu Met Pro Lys Glu Ile Tyr Lys Tyr Ile Lys Glu 
    770                 775                 780                 


Ile Lys Ile Asn Lys Thr Asn Tyr Ser Asp Arg Met Ser Ile Phe Tyr 
785                 790                 795                 800 


Leu Leu Leu Lys Leu Ile Asp His Lys Glu Leu Thr Asn Leu Arg Gly 
                805                 810                 815     


Asn Leu Glu Lys Tyr Glu Ser Met Asn Lys Asn Lys Ile Tyr Ser Glu 
            820                 825                 830         


Glu Leu Asn Ile Val Asn Leu Val Ser Leu Asp Asn Asn Lys Val Arg 
        835                 840                 845             


Thr Asn Phe Ser Val Glu Ala Glu Asp Ile Gly Lys Phe Leu Lys Thr 
    850                 855                 860                 


Glu Thr Ser Ile Lys Asn Ile Asn Gln Leu Asn Asn Phe Ser Gly Ile 
865                 870                 875                 880 


Phe Ala Asp Gly Glu Asn Val Ile Lys His Arg Ser Phe Tyr Asn Ile 
                885                 890                 895     


Lys Lys Tyr Gly Ile Leu Asp Leu Leu Glu Lys Ile Val Ala Lys Ala 
            900                 905                 910         


Asp Leu Lys Ile Ala Lys Glu Glu Ile Lys Lys Tyr Glu Asn Leu Gln 
        915                 920                 925             


Lys Glu Leu Glu Lys Asn Asp Phe Tyr Lys Ile Gln Glu Lys Ile His 
    930                 935                 940                 


Arg Lys Tyr Asn Gln Lys Pro Asn Leu Ile Ser Arg Thr Glu Asn Lys 
945                 950                 955                 960 


Lys Asp Phe Asn Asp Tyr Lys Lys Ala Ile Glu Asn Ile Gln Asn Tyr 
                965                 970                 975     


Thr Gln Leu Lys Asn Lys Ile Glu Phe Asn Asp Leu Asn Leu Leu Gln 
            980                 985                 990         


Gly Leu Leu Phe Arg Ile Leu His  Arg Leu Thr Gly Tyr  Thr Ser Leu 
        995                 1000                 1005             


Trp Glu  Arg Asp Leu Gln Phe  Lys Leu Lys Gly Glu  Phe Pro Glu 
    1010                 1015                 1020             


Asp Lys  Tyr Ile Asp Glu Ile  Phe Asn Ser Asp Arg  Asn Asn Asn 
    1025                 1030                 1035             


Gln Lys  Tyr Lys Ser Gly Gly  Ile Ala Tyr Lys Tyr  Val Asp Phe 
    1040                 1045                 1050             


Leu Ile  Glu Lys Glu Glu Gly  Lys Arg Ala Gly Lys  Asn Lys Val 
    1055                 1060                 1065             


Lys Lys  Arg Ser Glu Arg Glu  Arg Ser Phe Ile Ile  Arg Asn Tyr 
    1070                 1075                 1080             


Ile Ala  His Phe Asn Tyr Ile  Pro Asp Ala Glu Lys  Ser Ile Leu 
    1085                 1090                 1095             


Glu Ile  Leu Glu Glu Leu Arg  Glu Leu Leu Lys Tyr  Asp Arg Lys 
    1100                 1105                 1110             


Leu Lys  Asn Ala Val Met Lys  Ser Ile Lys Asp Ile  Phe Lys Glu 
    1115                 1120                 1125             


Tyr Gly  Phe Ile Ile Glu Phe  Gly Ile Ser His Glu  Ser Asn Ser 
    1130                 1135                 1140             


Lys Lys  Ile Lys Val Leu Asn  Val Glu Ser Gly Lys  Ile Lys His 
    1145                 1150                 1155             


Leu Lys  Asn Asn Gly Leu Val  Thr Thr Arg Asn Ser  Lys Asp Leu 
    1160                 1165                 1170             


Cys Lys  Leu Val Lys Val Met  Leu Glu Tyr Lys Lys  Ser 
    1175                 1180                 1185     


<210>  59
<211>  1144
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  59

Met Arg Ile Ser Lys Val Lys Val Thr Thr Asp Asp Lys Lys Gln Lys 
1               5                   10                  15      


Met Val Leu Met His Arg Thr Ile Lys Glu Gly Ser Leu Val Tyr Glu 
            20                  25                  30          


Lys Glu Thr Asp Asn Gln Thr Asn Asn Ile Leu Pro Arg Lys Lys Lys 
        35                  40                  45              


Asp Ser Phe Asn Leu Ser Ile Leu Asn Lys Thr Leu Ile Asn Glu Lys 
    50                  55                  60                  


His Ile Lys Ala Pro Tyr Thr Lys Asp Phe Asn Glu Lys Ala Lys Lys 
65                  70                  75                  80  


Glu Lys Glu Leu Lys Ser Lys Tyr Ser Gly Leu Lys Lys Ile Leu Gln 
                85                  90                  95      


Ala Gln Gly Asp Asn Tyr Met Gln Ile Lys Asn Ile Thr Glu Gly Glu 
            100                 105                 110         


Ile Thr Pro Phe Leu Ser Ser Lys Phe Lys Gly Asp Phe Thr Tyr Arg 
        115                 120                 125             


Thr Lys Ser Asp Val Tyr Thr Phe Asn Leu Thr Gln Leu Ile Ile Asn 
    130                 135                 140                 


Val Val Lys Lys Gln Asn Ile Arg Glu Leu Lys Pro Tyr Asn Asp Trp 
145                 150                 155                 160 


Lys Asp Trp Tyr Ile Gln Asn Lys Ser Lys Gln Leu Ala Lys Ser Val 
                165                 170                 175     


Glu Gln Asn Lys Ile Tyr Thr Gln Asp Gly Asn Ser Lys Arg Gln Leu 
            180                 185                 190         


Ala Leu Gln Glu Trp Glu Lys Glu Phe Leu Lys Asn Gly Lys Ile Asp 
        195                 200                 205             


Ile Asp Gln Leu His Lys Ala Tyr Lys Thr Asp Glu Leu Ala Ala Ala 
    210                 215                 220                 


Leu Ala Val Glu Asn Pro Lys Asn Asp Asp Glu Lys Asn Lys Arg Pro 
225                 230                 235                 240 


Gly Val Tyr His Ser Ala Leu Lys Asn Ile Leu Gln Ala His Gln Arg 
                245                 250                 255     


Arg Thr Glu Ile Phe Gly Thr Arg Glu Cys Pro Asn Ser Ala Asn Arg 
            260                 265                 270         


Ala Asp Asn Leu Phe Val Val Tyr His Asn Glu Val Val Lys Tyr Leu 
        275                 280                 285             


Glu His Tyr Phe Pro Val Lys Gln Ser Asn Arg Lys Asn Ser Glu Thr 
    290                 295                 300                 


Asp Ile Lys Tyr Tyr Leu Asn Ala Asp Thr Ile Lys Gln Thr Ile Lys 
305                 310                 315                 320 


Asn Gln Ile Glu Asn Ala Leu Arg Ala Asn Leu Ile Arg Lys Gly Lys 
                325                 330                 335     


Tyr Ile Gln His Gln Leu Ala Gly Ser Asp Thr Val Ser Ser Lys Glu 
            340                 345                 350         


Leu Ile Thr Met Lys Thr Asn Glu Ala Phe Val Leu Lys Leu Ile Asp 
        355                 360                 365             


Ala Cys Ala Phe Ala Ala Asn Asn Ile Arg Asn Ile Ile Asp Ile Thr 
    370                 375                 380                 


Gln Asn Arg Asp Ile Leu Val Lys Glu Asn Leu Ile Tyr Ser Ile Ser 
385                 390                 395                 400 


Gln Tyr Ser Ile Ser Gln Lys Asn Ala Asn Ile Glu Leu Phe Asn Gln 
                405                 410                 415     


Phe Phe Pro Tyr Asn Thr Asn Ala Leu Ser Ala Ile Asp Leu Trp Ala 
            420                 425                 430         


Leu Arg Gly Ala Val Gln Lys Ile Arg Asn Asn Ile Asn His Tyr Lys 
        435                 440                 445             


Ala Asn Ala Leu Ser Ile Ile Phe Asn Val Val Glu Phe Glu Tyr Gln 
    450                 455                 460                 


Pro Leu Lys Lys Val Ile Asn Glu Lys Phe Glu Lys Ser Ile Tyr Lys 
465                 470                 475                 480 


Ser Phe Phe Glu Lys Asp Ile Glu Lys Leu Pro Thr Val Phe Ala Leu 
                485                 490                 495     


Gln Leu Lys Ser Gly Gly Val Leu Ser His Tyr Pro Lys Gln Glu Leu 
            500                 505                 510         


Lys Asn Leu Leu Gly Glu Ile Lys Ile Glu Leu Cys Arg Ser Val Thr 
        515                 520                 525             


Pro Phe Ala Pro Gly Phe Lys Lys Val Met Lys Ala Gly Val Asn Tyr 
    530                 535                 540                 


Gln Phe Ala Lys Lys Glu Asp Phe Tyr Asp Leu Gly Leu Ser Ala Tyr 
545                 550                 555                 560 


Arg Glu Lys Glu Glu Phe Lys Glu Glu Asn Arg Asn Ala Arg Tyr Phe 
                565                 570                 575     


Leu Leu Lys Gln Leu Tyr Asn Tyr Val Phe Leu Pro Gln Phe Met Asn 
            580                 585                 590         


Asp Lys Ala Gln Phe His Gln Ile Val Lys Phe Val Leu Asp Gln Asn 
        595                 600                 605             


Lys Ala Phe Ala Arg Glu Ile Leu Arg Lys Lys Ser Ala Asp Lys Lys 
    610                 615                 620                 


Asn Leu Asn Pro Asn Ala Arg Pro Lys Ala Tyr Ala Phe Ala Glu Val 
625                 630                 635                 640 


Arg Glu Met Gly Glu Glu Glu Asp Ile Asn Thr Tyr Met Ala Tyr Leu 
                645                 650                 655     


Gln Ser Asp Trp Met Leu Glu Ser Ser Lys Lys Glu Glu Lys Lys Asn 
            660                 665                 670         


Ala Glu Glu Glu Thr Leu Asn Phe Glu Lys Phe Val Leu Gln Val Phe 
        675                 680                 685             


Val Lys Ala Phe Asp Glu Phe Leu Lys Ala Pro Lys Tyr Thr Phe Ile 
    690                 695                 700                 


Gln Thr Pro Glu Asn Gln Trp Ala Pro Glu Ser Thr Pro Glu Gln Gln 
705                 710                 715                 720 


Ala Asn Ala Leu Asn Ser Leu Glu Glu Glu Ile Arg Glu Tyr Cys His 
                725                 730                 735     


Ile Asn Thr Glu Phe Leu Lys Pro Asp Asn Asn Ala Asp Ile Ala Phe 
            740                 745                 750         


Tyr Val Phe Cys Lys Leu Leu Asp Thr Asn His Leu Ser Asp Val Arg 
        755                 760                 765             


Asn Glu Leu Ile Lys Tyr Arg Ala Val Lys Glu Asp Asp Lys Ile Phe 
    770                 775                 780                 


Lys His Leu Val Ser Ile Val Glu Leu Cys Leu Leu Ser Ala Asp Thr 
785                 790                 795                 800 


Val Ser Ala Asp Ala Val Arg Lys Gln Asn Asp Arg Gln Tyr Phe Lys 
                805                 810                 815     


Arg Ile Gln Pro Phe Phe Ala Thr Asp Cys Asp Pro Ser Lys Leu Gly 
            820                 825                 830         


Glu Leu Tyr Leu Gln Ser Asp Asn Ala Thr Ala Val Leu His Ser Gly 
        835                 840                 845             


Ile Lys Ile Ser Glu Lys Tyr Gly Thr Leu Pro Leu Met Glu Lys Ile 
    850                 855                 860                 


Ile Gln Thr Asp Asn Leu Phe Leu Ile Ser Lys Lys Asn Ala Asp Asp 
865                 870                 875                 880 


Trp His Thr Gly Lys Ser Ile Ile Glu Lys Val Ile Lys Glu Arg Glu 
                885                 890                 895     


Lys Leu His Asn Glu Trp Val Lys Ala Lys Glu Thr Asp Glu Lys Glu 
            900                 905                 910         


Arg Lys Glu His Val Arg Ile Lys Ser Lys Ser Ala Glu Asn Phe Ile 
        915                 920                 925             


Asn Asn Lys Gly Asn Glu Tyr Ala Glu Ile Cys Glu Tyr Ile Asp Thr 
    930                 935                 940                 


Tyr Asn Trp Leu Asp Asn Lys Leu His Phe Ile His Leu Lys Arg Leu 
945                 950                 955                 960 


His Asn Leu Thr Val Glu Ile Leu Gly Arg Leu Ala Gly Phe Val Ala 
                965                 970                 975     


Val Trp Glu Arg Asp Phe Gln Tyr Leu Glu Lys Arg Arg Ala Lys Thr 
            980                 985                 990         


Leu Gly Leu Thr Pro Leu Ser Phe  Asp Lys Gly Leu Pro  Ser Tyr Lys 
        995                 1000                 1005             


Asn Asn  Ser Lys Asn Val Leu  Asp Glu Phe Glu Ala  Tyr His Leu 
    1010                 1015                 1020             


Lys Thr  Phe Leu Cys Lys Asp  Tyr Arg Asn Ile Arg  Asn Arg Ile 
    1025                 1030                 1035             


Ala His  Tyr Glu Tyr Leu Asn  Ala Ser Val Lys Ala  Tyr Ser Leu 
    1040                 1045                 1050             


Ile Asp  Leu Ile Asn Gln Val  Arg Gln Leu Leu Ser  Tyr Asp Arg 
    1055                 1060                 1065             


Lys Leu  Lys Asn Ala Val Ala  Lys Ser Ile Ile Thr  Leu Phe Glu 
    1070                 1075                 1080             


Lys His  Gly Met Gln Leu Lys  Leu Thr Val Ser Asn  Thr Lys His 
    1085                 1090                 1095             


Gln Leu  Glu Ile Gln Glu Leu  Ile Pro Val Thr Leu  Asn His Leu 
    1100                 1105                 1110             


Gly Thr  Asn Ala Gly Ser Arg  Leu Pro Ile Ser Thr  Asn Arg Val 
    1115                 1120                 1125             


His Lys  Gln Tyr Cys Ala Met  Cys Arg Ala Leu Leu  Gln Tyr Arg 
    1130                 1135                 1140             


Glu 
    


<210>  60
<211>  1225
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  60

Met Lys Ile Thr Lys Arg Lys Trp Gly Glu His His Pro Pro Leu Tyr 
1               5                   10                  15      


Phe Tyr Arg Asp Glu Asp Ser Gly Arg Leu Leu Ala Gln Asn Asp Arg 
            20                  25                  30          


Lys Gln Asp Tyr Thr Asp Thr Leu Phe Asn Asp Ile Ala Gln Asp Thr 
        35                  40                  45              


Phe Glu Arg Ser Leu Arg Asn Arg Leu Leu Lys Thr Pro Glu Lys Gly 
    50                  55                  60                  


Asp Lys Arg Phe Tyr Ser Asn Glu Ile Val Lys Leu Val Glu Lys Leu 
65                  70                  75                  80  


Cys Gln Gly Ala Asp Val Ala Glu Ile Met Lys Ser Met Glu Arg Ser 
                85                  90                  95      


Glu Lys Leu Arg Pro Lys Asn Glu Lys Glu Ile Lys Asn Leu Lys Lys 
            100                 105                 110         


Gln Leu Asp Gly Thr Leu Ser Glu Tyr Gly Lys Arg Tyr Thr Ala Pro 
        115                 120                 125             


Glu Gly Ala Met Thr Leu Asn Asp Ala Leu Phe Tyr Leu Val Glu Gly 
    130                 135                 140                 


Asn Pro Leu Lys Gln Ala Met Ala Lys Ala Glu Leu Gly Lys Ile Arg 
145                 150                 155                 160 


Glu Ala Leu Ile Lys Glu Lys Glu Asn Arg Ile Asn Arg Val Arg Tyr 
                165                 170                 175     


Ser Ile Lys Asn Asn Lys Ile Pro Leu Arg Ile Gln Glu Asp Gly Gly 
            180                 185                 190         


Ile Thr Pro Asn Asn Asp Arg Ala Ala Trp Leu Leu Gly Leu Met Lys 
        195                 200                 205             


Pro Ala Asp Pro Ala Lys Gly Ile Thr Asp Cys Tyr Pro Leu Leu Gly 
    210                 215                 220                 


Glu Leu Glu Glu Val Phe Asp Phe Asp Lys Leu Ser Lys Thr Leu His 
225                 230                 235                 240 


Glu Lys Ile Ser Arg Cys Gln Gly Arg Pro Arg Ser Ile Ala Met Ala 
                245                 250                 255     


Val Asp Glu Ala Leu Lys Gln Tyr Leu Arg Glu Leu Trp Glu Lys Ser 
            260                 265                 270         


Pro Ser Arg Gln Gln Asp Leu Lys Tyr Tyr Phe Gln Ala Val Gln Glu 
        275                 280                 285             


Tyr Phe Lys Asp Asn Phe Pro Ile Arg Thr Lys Arg Met Gly Ala Arg 
    290                 295                 300                 


Leu Arg Gln Glu Leu Leu Lys Asp Lys Thr Ser Leu Ser Arg Leu Leu 
305                 310                 315                 320 


Glu Pro Lys His Met Ala Asn Ala Val Arg Arg Arg Leu Ile Asn Gln 
                325                 330                 335     


Ser Thr Gln Met His Ile Leu Tyr Gly Lys Leu Tyr Ala Tyr Cys Cys 
            340                 345                 350         


Gly Glu Asp Gly Arg Leu Leu Val Asn Ser Glu Thr Leu Gln Arg Ile 
        355                 360                 365             


Gln Val His Glu Ala Val Lys Lys Gln Ala Met Thr Ala Val Leu Trp 
    370                 375                 380                 


Ser Ile Ser Arg Leu Arg Tyr Phe Tyr Gln Phe Glu Asp Gly Asp Ile 
385                 390                 395                 400 


Leu Ser Asn Lys Asn Pro Ile Lys Asp Phe Arg Asp Lys Phe Leu Arg 
                405                 410                 415     


Asp Thr Asn Lys Tyr Thr His Glu Asp Val Glu Ala Cys Lys Glu Lys 
            420                 425                 430         


Leu Gln Asp Phe Phe Pro Leu Lys Glu Leu Gln Glu Lys Ile Lys Glu 
        435                 440                 445             


Asp Ala Lys Gly Leu Gln Glu Thr Asp Asn Lys Gln Ala Asp Thr Thr 
    450                 455                 460                 


Asp Phe Lys Ala Ile Gly His Ile Val Arg Asp Asp Arg Lys Leu Cys 
465                 470                 475                 480 


Asn Gln Leu Leu Ala Glu Cys Val Ser Cys Ile Gly Glu Leu Arg His 
                485                 490                 495     


His Ile Phe His Tyr Lys Asn Val Thr Leu Ile Gln Ala Leu Lys Arg 
            500                 505                 510         


Ile Ala Asp Lys Val Lys Pro Glu Asp Leu Ser Val Leu Arg Ala Ile 
        515                 520                 525             


Tyr Leu Leu Asp Arg Arg Asn Leu Lys Lys Ala Phe Ala Lys Arg Ile 
    530                 535                 540                 


Ser Ser Met Asn Leu Pro Leu Tyr Tyr Arg Glu Asp Leu Leu Ser Arg 
545                 550                 555                 560 


Ile Phe Lys Lys Glu Gly Thr Ala Phe Phe Leu Tyr Ser Ala Lys Ile 
                565                 570                 575     


Gln Met Thr Pro Ser Phe Gln Arg Val Tyr Glu Arg Gly Lys Asn Leu 
            580                 585                 590         


Arg Arg Glu Phe Glu Cys Glu Arg Met Lys Ala Glu Ala Ser Asn Gly 
        595                 600                 605             


Gln Asn Gly Gln Asp Gly Asp Arg Leu Lys Trp Phe Arg Gln Leu Ala 
    610                 615                 620                 


Ala Gly Asp Ser Ala Asp Thr His Phe Asn Trp Ala Val Glu Ala Tyr 
625                 630                 635                 640 


Ala Glu Ser Ala Ala Asp Val Glu Asn Asn Val Glu Phe Asp Thr Asp 
                645                 650                 655     


Val Asp Ala Gln Arg Ala Leu Arg Asn Leu Leu Leu Leu Ile Tyr Arg 
            660                 665                 670         


His His Phe Leu Pro Glu Val Gln Lys Asp Glu Thr Leu Val Thr Gly 
        675                 680                 685             


Lys Ile His Lys Val Leu Glu Arg Asn Arg Gln Leu Ser Glu Gly Gln 
    690                 695                 700                 


Gly Pro Asn Gln Gly Lys Ala His Gly Tyr Ser Val Ile Glu Glu Leu 
705                 710                 715                 720 


Tyr His Glu Gly Met Pro Leu Ser Asp Leu Met Lys Gln Leu Gln Arg 
                725                 730                 735     


Arg Ile Ser Glu Thr Glu Arg Glu Ser Arg Glu Leu Ala Gln Glu Lys 
            740                 745                 750         


Thr Asp Tyr Ala Gln Arg Phe Ile Leu Asp Ile Phe Ala Glu Ala Phe 
        755                 760                 765             


Asn Asp Phe Leu Glu Ala His Tyr Gly Glu Glu Tyr Leu Glu Ile Met 
    770                 775                 780                 


Ser Pro Arg Lys Asp Ala Glu Ala Ala Lys Lys Trp Val Lys Glu Ser 
785                 790                 795                 800 


Lys Thr Val Asp Leu Lys Thr Ser Ile Asp Glu Lys Glu Pro Glu Gly 
                805                 810                 815     


His Leu Leu Val Leu Tyr Pro Val Leu Arg Leu Leu Asp Glu Arg Glu 
            820                 825                 830         


Leu Gly Glu Leu Gln Gln Gln Met Ile Arg Tyr Arg Thr Ser Leu Ala 
        835                 840                 845             


Ser Trp Gln Gly Glu Ser Asn Phe Ser Glu Glu Ile Arg Ile Ala Gly 
    850                 855                 860                 


Gln Ile Glu Glu Leu Thr Glu Leu Val Lys Leu Thr Glu Pro Glu Pro 
865                 870                 875                 880 


Gln Phe Ala Glu Glu Val Trp Gly Lys Arg Ala Lys Glu Ala Phe Glu 
                885                 890                 895     


Asp Phe Ile Glu Gly Asn Met Lys Asn Tyr Glu Ala Phe Tyr Leu Gln 
            900                 905                 910         


Ser Asp Asn Asn Thr Pro Val Tyr Arg Arg Asn Met Ser Arg Leu Leu 
        915                 920                 925             


Arg Ser Gly Leu Met Gly Val Tyr Gln Lys Val Leu Ala Ser His Lys 
    930                 935                 940                 


Gln Ala Leu Lys Arg Asp Tyr Leu Leu Trp Ser Glu Lys His Trp Asn 
945                 950                 955                 960 


Val Lys Asp Glu Asn Gly Ala Asp Ile Ser Ser Ala Glu Gln Ala Gln 
                965                 970                 975     


Cys Leu Leu Gln Arg Leu His Arg Lys Tyr Ala Glu Ser Pro Ser Arg 
            980                 985                 990         


Phe Thr Glu Glu Asp Cys Lys Leu  Tyr Glu Lys Val Leu  Arg Arg Leu 
        995                 1000                 1005             


Glu Asp  Tyr Asn Gln Ala Val  Lys Asn Leu Ser Phe  Ser Ser Leu 
    1010                 1015                 1020             


Tyr Glu  Ile Cys Val Leu Asn  Leu Glu Ile Leu Ser  Arg Trp Val 
    1025                 1030                 1035             


Gly Phe  Val Gln Asp Trp Glu  Arg Asp Met Tyr Phe  Leu Leu Leu 
    1040                 1045                 1050             


Ala Trp  Val Arg Gln Gly Lys  Leu Asp Gly Ile Lys  Glu Glu Asn 
    1055                 1060                 1065             


Val Arg  Asp Ile Phe Ser Glu  Gly Asn Ile Ile Arg  Asn Leu Val 
    1070                 1075                 1080             


Asp Thr  Leu Lys Gly Glu Asn  Met Asn Ala Phe Glu  Ser Val Tyr 
    1085                 1090                 1095             


Phe Pro  Glu Asn Lys Gly Ser  Lys Tyr Leu Gly Val  Arg Asn Asp 
    1100                 1105                 1110             


Val Ala  His Leu Asp Leu Met  Arg Lys Asn Gly Trp  Arg Leu Glu 
    1115                 1120                 1125             


Ala Gly  Lys Thr Cys Ser Val  Met Glu Asp Tyr Ile  Asn Arg Leu 
    1130                 1135                 1140             


Arg Phe  Leu Leu Ser Tyr Asp  Gln Lys Arg Met Asn  Ala Val Thr 
    1145                 1150                 1155             


Lys Thr  Leu Gln Gln Ile Phe  Asp Arg His Lys Val  Lys Ile Arg 
    1160                 1165                 1170             


Phe Thr  Val Glu Lys Gly Gly  Met Leu Lys Ile Glu  Asp Val Thr 
    1175                 1180                 1185             


Ala Asp  Lys Ile Val His Leu  Lys Gly Ser Arg Leu  Ser Gly Ile 
    1190                 1195                 1200             


Glu Ile  Pro Ser His Gly Glu  Arg Phe Ile Asp Thr  Leu Lys Ala 
    1205                 1210                 1215             


Leu Met  Val Tyr Pro Arg Gly  
    1220                 1225 


<210>  61
<211>  1146
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  61

Met Arg Leu Pro Glu Leu Val Glu Asn Leu Cys Lys Asp Ala Asp Ile 
1               5                   10                  15      


Gln Ser Ile Asp Lys Ile Lys Gly Ser Lys Ser Asp Met Lys Ala Leu 
            20                  25                  30          


Cys Asp Lys Thr Leu Thr Ala Tyr Gly Lys Ser Phe Ala Ala Glu Glu 
        35                  40                  45              


Gly Gly Thr Thr Leu Tyr Glu Ala Ile Leu Asn Leu Ala Asn Gly Asn 
    50                  55                  60                  


Ala Ile Gln Lys Ala Met Ala Glu Ala Glu Leu Lys Lys Ile Gln Lys 
65                  70                  75                  80  


Ala Leu Lys Lys Glu Lys Glu Asp Arg Ile Asn Arg Val Arg Asn Ser 
                85                  90                  95      


Ile Arg Lys Asn Lys Ile Pro Leu Lys Val Asn Ala Asp Gly Thr Ile 
            100                 105                 110         


Ser Ala Asn Asn Asp Arg Ala Ala Trp Leu Leu Glu Leu Leu Lys Pro 
        115                 120                 125             


Val Ala Ser Glu His Asp Lys Asp Asp Arg Tyr Pro Val Leu Thr Glu 
    130                 135                 140                 


Met Glu Glu Ile Val Ser Phe Asp Lys Leu Cys Glu Glu Val Arg Lys 
145                 150                 155                 160 


Lys Ile Gln Ser Cys Lys Ser Gly Ala Arg Ser Arg Ala Met Leu Ala 
                165                 170                 175     


Asp Glu Ala Val Lys Glu Tyr Leu Lys Ala Leu Trp Glu Lys His Thr 
            180                 185                 190         


Asp Arg His Arg Asp Met Arg Tyr Tyr Phe Gln Ala Val Lys Glu Tyr 
        195                 200                 205             


Phe Asn Lys Asn Phe Pro Ile Arg Thr Lys Gln Arg Gly Ala Ser Ile 
    210                 215                 220                 


Arg Gln Arg Leu Leu Met Glu Glu Thr Val Val Thr Arg Leu Leu Asn 
225                 230                 235                 240 


Pro Lys His Met Ala Lys Ala Val Arg Arg Lys Leu Ile Asn Gln Ser 
                245                 250                 255     


Thr Gln Met His Ile Leu Tyr Gly Lys Leu Tyr Glu Tyr Cys Cys Arg 
            260                 265                 270         


Lys Gly Arg Asn Leu Pro Val Asn Ser Glu Thr Leu Gln Leu Ile Gln 
        275                 280                 285             


Val Leu Glu Ala Val Lys Lys Gln Leu Met Thr Ala Val Ser Trp Ser 
    290                 295                 300                 


Val Ser Arg Leu Cys Tyr Phe Tyr Glu Phe Tyr Ile Gly Asp Ile Leu 
305                 310                 315                 320 


Leu Ala Gly Lys Tyr Arg Arg Asp Phe Leu Ile Lys Gln Asn Asn Asn 
                325                 330                 335     


Arg Lys Asp Ile Gln Ala Cys Lys Glu Lys Leu Gln Asp Phe Phe Gln 
            340                 345                 350         


Leu Ala Glu Leu Gln Glu Lys Ile Lys Glu Ser Ala Asp Glu Asp Ile 
        355                 360                 365             


Asn Leu Thr Glu Thr Ile Thr Asn Asp Ala Leu Val Cys Asn Lys Leu 
    370                 375                 380                 


Leu Glu Glu Cys Ala Phe Cys Ile Ser Lys Leu Arg Asn Asn Ile Phe 
385                 390                 395                 400 


His Tyr Lys Asn Leu Gly Phe Thr Gln Ala Leu Lys His Ile Ala Asn 
                405                 410                 415     


Glu Ile Lys Lys Glu Asp Val Pro Val Leu Leu Arg Leu Tyr Lys Gln 
            420                 425                 430         


Asp Cys Glu Asn Leu Asn Asn Ala Phe Ala Ser Arg Ile Ser Ser Met 
        435                 440                 445             


Asn Ile Pro Leu Tyr Tyr Ser Thr Glu Phe Leu Leu Arg Ile Phe Lys 
    450                 455                 460                 


Lys Gln Gly Val Glu Leu Ser Leu Tyr Ser Ala Lys Tyr Gln Met Thr 
465                 470                 475                 480 


Pro Ser Phe Lys Arg Val Tyr Glu Arg Gly Lys Asn Leu Arg Leu Glu 
                485                 490                 495     


Tyr Glu Arg Glu Ser Met Arg Ser Asn Ile Ala Asn Glu Asp Gly Asn 
            500                 505                 510         


Asp Leu Gln Asn Gly Asn Trp Leu Arg Trp Phe Ser Gln Leu Glu Ala 
        515                 520                 525             


Gly Ile Val Asp Thr Asp Ala Gly Met Lys Gly Asp Ile Gly Asp Tyr 
    530                 535                 540                 


Pro Asp Thr Ser Ala Asp Leu Gly Ile Glu Ala Glu Thr Gly Thr Asn 
545                 550                 555                 560 


Thr Asp Ala Gln Arg Ala Met Arg Asn Leu Leu Gln Leu Ile Tyr Lys 
                565                 570                 575     


Tyr His Phe Leu Pro Glu Val Gln Lys Asn Glu Asn Ile Val Thr Asp 
            580                 585                 590         


Leu Ile Pro Lys Val Leu Glu Arg Asn Arg Lys Leu Ser Glu Val Arg 
        595                 600                 605             


Asn Arg Ser Asp Lys Thr Tyr Gly Tyr Lys Glu Ile Glu Glu Leu Tyr 
    610                 615                 620                 


Lys Lys Asn Lys Gly Lys Lys Asp Ser Leu Ser Glu Leu Leu Lys Asp 
625                 630                 635                 640 


Leu Gln Arg Lys Val Ser Glu Thr Glu Lys Glu Asn Gln Glu Leu Ala 
                645                 650                 655     


Arg Glu Lys Thr Asp Tyr Ala Gln Arg Phe Ile Leu Asp Ile Phe Ala 
            660                 665                 670         


Glu Ala Phe Ser Asn Phe Met Asp Asp Arg Tyr Glu Asp Glu Tyr Gln 
        675                 680                 685             


Glu Ile Met Asn Pro Lys Lys Asp Glu Glu Lys Ala Lys Lys Trp Ala 
    690                 695                 700                 


Glu Leu Phe Thr Glu Lys Ala Asp Lys Asp Asn Arg Lys Asp Glu Pro 
705                 710                 715                 720 


Leu Val Leu Lys Thr Ser Phe Asp Lys Asp Asn Ile Glu Lys Phe Leu 
                725                 730                 735     


Leu Val Leu Tyr Pro Leu Met Arg Leu Leu Asp Asp Lys Glu Leu Ser 
            740                 745                 750         


Glu Leu Gln Gln Gln Met Leu Arg Phe Arg Ala Ser Val Ser Gly Trp 
        755                 760                 765             


Gln Gly Ser Thr Asp Phe Asn Glu Asp Ile Ala Met Ala Glu Lys Ile 
    770                 775                 780                 


Glu Glu Leu Ala Glu Leu Val Lys Leu Thr Glu Pro Glu Ser Gln Cys 
785                 790                 795                 800 


Ala Glu Val Ser Trp Lys Asn Arg Ala Ile Glu Val Phe Glu Gln Phe 
                805                 810                 815     


Val Glu Gly Lys Met Ala Glu Tyr Gly Ala Phe Tyr Leu Gln Ser Asp 
            820                 825                 830         


Thr Leu Thr Pro Val Pro Arg Arg Asn Met Lys Glu Leu Leu Arg Ser 
        835                 840                 845             


Gly Ile Met Gly Val Phe Lys Lys Val Leu Leu Ser His Met Gln Ala 
    850                 855                 860                 


Thr Lys Lys Asp Tyr Gly Val Tyr Ser Gly Glu His Trp Asn Ile Asp 
865                 870                 875                 880 


Asp Pro Ala Gly Asn Pro Ile Lys Ser Ala Glu Gln Ala His Ala Leu 
                885                 890                 895     


Leu Gln Arg Leu His Asn Lys Tyr Thr Glu Ser Pro Ser Gln Phe Ser 
            900                 905                 910         


Tyr Glu Asp Tyr Lys Leu Tyr Asp Arg Thr Ile Arg Gln Leu Asp Glu 
        915                 920                 925             


Tyr Asn Gln Ala Lys Lys Asn Leu Ser Phe Gly Ser Leu Tyr Glu Val 
    930                 935                 940                 


Cys Arg Ile Leu Leu Asp Met Leu Ser Arg Trp Val Gly Phe Val Gln 
945                 950                 955                 960 


Asp Trp Glu Arg Asp Met Tyr Phe Leu Leu Leu Ala Trp Ala Lys Gln 
                965                 970                 975     


Gly Lys Leu His Asn Val Thr Glu Thr Asp Val Leu Glu Val Phe Asn 
            980                 985                 990         


Glu Gly Arg Val Ile Cys Lys Leu  Asn Lys Lys Leu Lys  Asp Gly Asp 
        995                 1000                 1005             


Trp His  Ala Phe Ala Ser Ile  Tyr Cys Asn Asn Ser  Gly Glu Lys 
    1010                 1015                 1020             


Leu Glu  Phe Leu Gln Val Arg  Asn Phe Ile Ala His  Leu His Leu 
    1025                 1030                 1035             


Leu Arg  Glu Ser Glu Trp Asn  Gly Asp Glu Lys Thr  Gly Cys Ser 
    1040                 1045                 1050             


Ala Ile  Glu Asp Tyr Ile Asn  Lys Leu Arg Phe Leu  Leu Ser Tyr 
    1055                 1060                 1065             


Asp Gln  Lys Arg Met Asn Ala  Val Thr Lys Ala Met  Gln Gln Ile 
    1070                 1075                 1080             


Phe Gly  Lys His Lys Thr Lys  Ile Ile Phe Thr Val  Glu Lys Gly 
    1085                 1090                 1095             


Gly Lys  Ile Lys Ile Glu Asp  Val Val Ser Asp Asn  Val Ile His 
    1100                 1105                 1110             


Leu Lys  Gln Tyr Lys Pro Lys  Asp Ile Ile Lys Val  Pro Cys His 
    1115                 1120                 1125             


Gly Glu  Arg Phe Ile Gly Ser  Leu Leu Ala Leu Met  Lys Tyr Gln 
    1130                 1135                 1140             


Glu Lys  Ala 
    1145     


<210>  62
<211>  1216
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  62

Met Lys Gly Val Pro Asn Met Lys Ile Thr Lys Arg Lys Trp Glu Asp 
1               5                   10                  15      


Val Pro Pro Leu Phe Phe His Arg Asp Lys Asp Ser Gly Arg Leu Ile 
            20                  25                  30          


Arg Gln Asp Asp Arg Glu His Asp Tyr Thr Asp Glu Leu Phe Arg Lys 
        35                  40                  45              


Thr Thr Val Asp Ser Ile Phe Ile Arg Ser Leu Gln Asn Arg Leu Leu 
    50                  55                  60                  


Arg Ser Gln Asp Lys Glu Gly Asn Lys Ile Gly Arg Asn Glu Ile Thr 
65                  70                  75                  80  


Glu Leu Val Glu Asn Leu Cys Lys Gly Ala Glu Ile Gln Lys Ser Ile 
                85                  90                  95      


Asp Glu Ile Lys Asp Ser Lys Ser Asn Val Lys Ala Leu Cys Asp Lys 
            100                 105                 110         


Thr Leu Thr Asp Tyr Gly Lys Ser Phe Ala Ala Glu Glu Gly Arg Thr 
        115                 120                 125             


Thr Leu Tyr Glu Ala Ile Leu Asn Leu Ala Lys Gly Asn Ala Ile Gln 
    130                 135                 140                 


Lys Ala Met Ala Glu Ala Glu Leu Lys Gln Ile His Glu Ala Leu Lys 
145                 150                 155                 160 


Lys Glu Lys Glu Asp Arg Ile Asn Arg Val Gln Asn Ser Ile Lys Asn 
                165                 170                 175     


Asn Lys Ile Pro Leu Lys Val Asn Glu Asp Gly Thr Ile Ser Ala Asn 
            180                 185                 190         


Asn Asp Arg Ala Ser Trp Leu Leu Glu Leu Leu Lys Pro Val Ala Ser 
        195                 200                 205             


Glu His Asp Lys Gly Asp Arg Tyr Pro Val Leu Thr Glu Met Glu Gly 
    210                 215                 220                 


Ile Val Ser Phe Asp Lys Leu Cys Glu Glu Val Arg Asn Lys Ile His 
225                 230                 235                 240 


Gly Arg Lys Gly Arg Thr Arg Ser Ile Ala Met Ser Val Asp Glu Ala 
                245                 250                 255     


Val Lys Glu Tyr Leu Lys Glu Leu Trp Lys Lys His Ala Asp Arg His 
            260                 265                 270         


Arg Asp Met Arg Tyr Tyr Phe Gln Ala Val Lys Glu Tyr Phe Lys Glu 
        275                 280                 285             


Asn Phe Pro Ile Arg Thr Lys Gln Lys Gly Ala Gly Ile Arg Gln Ser 
    290                 295                 300                 


Leu Leu Lys Glu Asp Thr Val Val Ala Arg Leu Leu Asp Pro Lys His 
305                 310                 315                 320 


Met Ala Lys Ala Val Arg Arg Lys Leu Ile Asn Gln Ser Thr Gln Met 
                325                 330                 335     


His Ile Leu Tyr Gly Lys Leu Tyr Glu Tyr Cys Cys Arg Glu Asp Arg 
            340                 345                 350         


Asn Leu Pro Val Asn Ser Glu Thr Leu Gln Leu Ile Gln Val Leu Glu 
        355                 360                 365             


Ala Val Lys Lys Gln Leu Met Thr Ala Val Leu Trp Ser Val Ser Arg 
    370                 375                 380                 


Leu Cys Tyr Phe Tyr Glu Phe Tyr Ser Gly Asp Ile Leu Leu Ala Glu 
385                 390                 395                 400 


Glu Tyr Arg Arg Asp Phe Leu Asn Gln Lys Asn Asp His Lys Asp Ile 
                405                 410                 415     


Gln Ala Cys Lys Glu Lys Leu Gln Asp Phe Phe Pro Leu Ala Glu Leu 
            420                 425                 430         


Gln Glu Lys Ile Arg Glu Cys Ala Asp Lys Asp Ile Asn Asn Ile Lys 
        435                 440                 445             


Asp Lys Ile Thr Asn Asp Val Leu Ala Cys Asn Asn Leu Leu Glu Glu 
    450                 455                 460                 


Cys Val Phe Cys Ile Ser Lys Leu Arg Asn Asn Ile Phe His Tyr Lys 
465                 470                 475                 480 


Asn Leu Ser Phe Thr Gln Ala Leu Lys His Ile Ala Asn Glu Ile Lys 
                485                 490                 495     


Glu Glu Asp Ile Pro Ile Ile Leu Arg Leu Tyr Lys Gln Asp Cys Glu 
            500                 505                 510         


Asn Val Asn Lys Ala Phe Ala Asn Arg Ile Ser Ser Met Asn Leu Pro 
        515                 520                 525             


Leu Tyr Tyr Ser Thr Glu Phe Leu Leu Arg Ile Phe Lys Lys Gln Gly 
    530                 535                 540                 


Ala Glu Leu Ser Leu Tyr Ser Thr Lys Asn Gln Met Thr Pro Ser Phe 
545                 550                 555                 560 


Lys Arg Val Tyr Glu Arg Gly Lys Asn Leu Arg Leu Glu Tyr Glu Arg 
                565                 570                 575     


Glu Pro Met Arg Ser Asn Ile Ala Asn Glu Tyr Asp Lys Asp Pro Gln 
            580                 585                 590         


Ser Asp Tyr Trp Met Arg Trp Phe Ser Gln Phe Ala Thr Gly Thr Val 
        595                 600                 605             


Asp Thr Asn Ala Gly Ile Lys Gly Glu Met Glu Asp Tyr Pro His Ala 
    610                 615                 620                 


Ser Val Asn Leu Gly Ile Glu Ile Glu Ala Gly Thr Asn Ile Asp Ala 
625                 630                 635                 640 


Gln Arg Ala Met Arg Asn Leu Leu Gln Leu Ile Tyr Lys His His Phe 
                645                 650                 655     


Leu Pro Glu Val Gln Lys Asp Glu Thr Val Val Thr Asp Val Ile Pro 
            660                 665                 670         


Lys Val Leu Glu Arg Asn Arg Lys Leu Ser Glu Val Arg Asn Arg Ser 
        675                 680                 685             


Asp Lys Thr Tyr Gly Tyr Lys Glu Ile Glu Glu Leu Cys Lys Lys Asn 
    690                 695                 700                 


Lys Gly Lys Lys Asp Ser Leu Ser Glu Leu Met Lys Asp Leu Gln Arg 
705                 710                 715                 720 


Lys Val Ser Glu Thr Glu Lys Glu Lys Arg Glu Leu Ala Arg Glu Lys 
                725                 730                 735     


Thr Asp Tyr Ala Gln Arg Phe Ile Leu Asp Ile Phe Ala Glu Ala Phe 
            740                 745                 750         


Cys Asn Phe Met Asp Glu Arg Tyr Glu Asp Glu Tyr Gln Glu Ile Met 
        755                 760                 765             


Ser Pro Ile Lys Asn Glu Glu Glu Ala Lys Lys Trp Thr Glu Met Phe 
    770                 775                 780                 


Thr Asp Lys Ala Asp Lys Asp Asn Lys Asp Lys Leu Leu Val Leu Lys 
785                 790                 795                 800 


Thr Ser Phe Asp Lys Asp Asn Val Glu Lys Tyr Leu Leu Val Leu Tyr 
                805                 810                 815     


Pro Leu Met Arg Leu Leu Asp Asp Lys Glu Leu Ser Glu Leu Gln Gln 
            820                 825                 830         


Gln Met Leu Arg Phe Arg Ala Ser Val Ser Gly Trp Gln Gly Gly Thr 
        835                 840                 845             


Asp Phe Ser Glu Asp Ile Ala Met Ala Glu Lys Ile Glu Glu Leu Ala 
    850                 855                 860                 


Glu Leu Val Lys Leu Thr Glu Pro Glu Ser Gln Tyr Ala Glu Glu Ala 
865                 870                 875                 880 


Trp Lys Asn Arg Ala Ile Gly Val Phe Glu Gln Phe Val Glu Gly Lys 
                885                 890                 895     


Met Ala Glu Tyr Gly Thr Phe Tyr Ile Gln Asn Asp Ser Leu Thr Gln 
            900                 905                 910         


Val Pro Arg Gly Asn Met Arg Lys Leu Leu Arg Ser Gly Val Ile Gly 
        915                 920                 925             


Val Tyr Asn Lys Val Leu Ala Ser Cys Lys Gln Ala Thr Lys Ala Asp 
    930                 935                 940                 


Tyr Gly Ala Tyr Ser Gly Asp His Trp Ser Ile Glu Asp Pro Asp Gly 
945                 950                 955                 960 


Asn Pro Ile Lys Ser Ala Glu Gln Ala Gln Ala Leu Leu Gln Arg Leu 
                965                 970                 975     


His Lys Lys Tyr Thr Glu Ser Pro Ser Gln Phe Ser Asp Asp Asp His 
            980                 985                 990         


Lys Leu Tyr Asp Lys Thr Leu Arg  Gln Leu Asp Ala Tyr  Asn Arg Ala 
        995                 1000                 1005             


Met Lys  Asn Leu Ser Phe Gly  Ser Leu Tyr Glu Ile  Cys Arg Ile 
    1010                 1015                 1020             


His Met  Glu Thr Leu Ser Arg  Trp Val Gly Phe Val  Gln Asp Trp 
    1025                 1030                 1035             


Glu Arg  Asp Met Tyr Phe Leu  Leu Leu Ala Trp Thr  Lys Gln Gly 
    1040                 1045                 1050             


Lys Leu  Leu Asn Val Thr Glu  Thr Asp Val Ile Glu  Ile Phe Glu 
    1055                 1060                 1065             


Lys Gly  Ser Val Ile Tyr Lys  Met Asn Lys Lys Leu  Lys Asn Gly 
    1070                 1075                 1080             


Asp Arg  Tyr Ala Phe Thr Ser  Ile Tyr Arg Asn Asn  Asn Asp Glu 
    1085                 1090                 1095             


Lys Leu  Glu Phe Leu Gln Ile  Arg Asn Phe Ile Ala  His Leu His 
    1100                 1105                 1110             


Leu Leu  Arg Lys Ser Glu Trp  Lys Gly Asp Lys Lys  Ala Gly Tyr 
    1115                 1120                 1125             


Ser Val  Ile Glu Asp Tyr Ile  Asn Lys Leu Arg Phe  Leu Leu Ser 
    1130                 1135                 1140             


Tyr Asp  Gln Lys Arg Met Asn  Ala Val Thr Lys Ala  Met Gln Gln 
    1145                 1150                 1155             


Ile Phe  Glu Lys His Lys Val  Ile Val Lys Phe Met  Val Glu Lys 
    1160                 1165                 1170             


Gly Gly  Met Leu Lys Val Lys  Asp Val Lys Pro Gly  Ile Ile Glu 
    1175                 1180                 1185             


His Leu  Lys Gln Thr Lys Arg  Ile Glu Ile Pro Cys  His Gly Glu 
    1190                 1195                 1200             


Arg Phe  Thr Asp Ser Leu Leu  Val Leu Met Lys Tyr  Gln 
    1205                 1210                 1215     


<210>  63
<211>  1284
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  63

Met Ile Ile Gly Gly Ile Asn Met Lys Leu Thr Arg Arg Arg Ile Ser 
1               5                   10                  15      


Gln Glu Arg Lys Asn Gln Lys Leu Thr Ala Ala Phe Tyr Arg Asp Met 
            20                  25                  30          


Asp His Gly Leu Leu Tyr Val Asp Ser Glu Asp Glu Asp Arg Thr Glu 
        35                  40                  45              


Tyr Val Val Ser Ser Met Asp Phe Glu Arg Ser Trp Arg Gly Arg Ile 
    50                  55                  60                  


Leu Lys Asn Gly Glu Asp Asn Lys Asn Pro Phe Tyr Glu Phe Val Lys 
65                  70                  75                  80  


Gly Leu Val Gly Ser Asn Glu Ile Ile Cys Lys Pro Ile Thr Asn Asp 
                85                  90                  95      


Asn Asn Thr Asp Ile Asn Glu Lys Ile Lys Lys Tyr Ile Thr Glu Phe 
            100                 105                 110         


Gly Arg Asn Leu Lys Ala Pro Gly Ser Glu Val Thr Leu Glu Lys Leu 
        115                 120                 125             


Ile Leu Asn Ile Gln Ser Gly Thr Ser Glu Asn Glu Val Arg Pro Glu 
    130                 135                 140                 


Leu Glu Lys Ile Lys Asp Met Ile Lys Lys Asp Ile Glu Lys Arg Lys 
145                 150                 155                 160 


Asp Glu Leu Ile Lys Ser Ile Thr Asn Asn His Ile Pro Phe Met Leu 
                165                 170                 175     


Asp Glu Asp Lys Leu Val Pro Ser Thr Lys Lys Met Lys Trp Leu Tyr 
            180                 185                 190         


Lys Phe Leu Asn Gly Pro Asp Lys Ser Leu Asn Leu Gln Met Phe Asp 
        195                 200                 205             


Glu Tyr Trp Thr Lys Tyr Gly Tyr Lys Asn Leu Glu Glu Lys Ile Ile 
    210                 215                 220                 


Lys Glu Ile Asn Ser Leu Pro Glu Lys Asn Ala Arg Ser Ile Ser Arg 
225                 230                 235                 240 


Ala Val Ser Lys Thr Val Arg Glu Tyr Asn Arg Asn Phe Arg Ile Asn 
                245                 250                 255     


Tyr Met Val Pro Glu Asn Glu Asn Ala Glu Ala Asp Ser Asp Tyr Glu 
            260                 265                 270         


Gly Phe Leu Leu Phe Leu Lys Ala Val Glu Gln His Phe Lys Lys Tyr 
        275                 280                 285             


Tyr Pro Val Lys Ser Lys Asp Ser Asn Glu Val Arg Asp Lys Asn Leu 
    290                 295                 300                 


Cys Glu Glu Lys Asn Tyr Lys Phe Tyr Cys Ser Tyr Asn Phe Val Lys 
305                 310                 315                 320 


Asn Glu Val Lys Arg Ser Ile Ile Asn Gln Leu Val Ser Gly Leu Ile 
                325                 330                 335     


Gln Gln Gly Lys Leu Leu His Tyr Phe Tyr Lys Asp Gly Ile Trp Gln 
            340                 345                 350         


Gln Asp Phe Leu Asn Ser Tyr Gly Leu Ser Tyr Ile Gln Val Glu Glu 
        355                 360                 365             


Ser Phe Lys Lys Ser Leu Met Thr Ser Leu Ser Trp Gly Ile Asn Arg 
    370                 375                 380                 


Leu Thr Ser Phe Phe Ile Asp Val Gly Thr Asp Glu Asn Glu Glu Lys 
385                 390                 395                 400 


Thr Val Gln Asn Lys Lys Gln Lys Asn Asn Arg Lys Ile Asp Asp Ile 
                405                 410                 415     


Leu Ser Asp Lys Ser Asn Leu Arg Ala Ile Phe Asn Asp Leu Arg Ser 
            420                 425                 430         


Asn Thr Glu Leu Gln Lys His Phe Lys Glu Lys Leu Ala Phe Cys Tyr 
        435                 440                 445             


Pro Ile Phe Ile Lys Val Lys Lys Glu Lys Met Phe Asp Asp Ile Glu 
    450                 455                 460                 


Lys Leu Ile Lys Leu Val Glu Glu Ala Arg Glu Ser Val Ala Tyr Leu 
465                 470                 475                 480 


Arg His Arg Cys Phe His Tyr Lys Asp Val Thr Ile Thr Glu Met Leu 
                485                 490                 495     


Lys Ala Leu Asn Asn Asn Thr Glu Thr Asp Lys Thr Glu Asp Ile Asp 
            500                 505                 510         


Tyr Ser Val Ala Ala Glu Tyr Phe Leu Arg Asp Ile Asn Asn Leu Tyr 
        515                 520                 525             


Asp Ala Phe Arg Glu Gln Ile Arg Ser Ser Gly Ile Ala Asp Tyr Tyr 
    530                 535                 540                 


Pro Ala Asp Ile Ile Ser Gly Cys Phe Lys Lys Cys Gly Leu Gln Phe 
545                 550                 555                 560 


Val Leu Tyr Ser Pro Gln Asn Ser Leu Met Pro Ser Phe Lys Asn Ile 
                565                 570                 575     


Tyr Lys Arg Gly Ser Asn Leu Tyr Lys Ala Tyr Gln Glu Glu Lys Glu 
            580                 585                 590         


Gln Lys Asp Lys Glu Tyr Lys Arg His Asn Thr Asn Ile Val Gln Glu 
        595                 600                 605             


Glu Ser Lys Glu Leu Ser Trp Tyr Ile Glu Val Ser Asp Thr Glu Gln 
    610                 615                 620                 


Gly Lys Thr Ala Tyr Arg Asn Leu Leu Gln Leu Ile Tyr Tyr His Ala 
625                 630                 635                 640 


Phe Leu Pro Glu Val Arg Glu Asn Glu Ser Leu Ile Thr Val Tyr Phe 
                645                 650                 655     


Ala Lys Thr Lys Glu Trp Asn Arg Lys Val Ala Glu Thr Lys Ala Lys 
            660                 665                 670         


Lys Lys Asn Ala Gly Lys Thr Tyr Lys Asp Lys Pro Ile Arg Ala Tyr 
        675                 680                 685             


Arg Tyr Glu Ala Ile Pro Asp Tyr Val Gly Glu Arg Leu Asp Asp Tyr 
    690                 695                 700                 


Phe Lys Ile Leu Gln Arg Glu Gln Met Ala Lys Ala Lys Asp Val Asn 
705                 710                 715                 720 


Glu Gly Asn Ala Glu Asn Asn Asn Tyr Ile Gln Phe Ile Arg Asp Val 
                725                 730                 735     


Val Val Trp Ala Phe Gly Ala Tyr Leu Glu Glu Arg Leu Glu Lys Tyr 
            740                 745                 750         


Lys Lys Asp Leu Gln Ser Ser His Ser Gln Lys Asp Lys Lys Asp Val 
        755                 760                 765             


Asn Asp Ala Leu Lys Glu Leu Phe Pro Asp Asp Lys Asp Lys Arg Gln 
    770                 775                 780                 


Phe Phe Met Lys Cys Lys Phe Thr Asp Val Leu Ile Asn Asp Val Gly 
785                 790                 795                 800 


Glu Asn Asn Gln Ile Thr Glu Met Glu Asp Leu Glu Thr Ser Lys Glu 
                805                 810                 815     


Gln Gln Asn Arg Glu Ile Lys Arg Lys Asp Leu Leu Cys Phe Tyr Leu 
            820                 825                 830         


Phe Leu Arg Leu Leu Asp Glu Arg Glu Ile Ser Gly Leu Lys His Gln 
        835                 840                 845             


Phe Val Arg Tyr Arg Cys Ser Leu Lys Glu Arg Arg Leu Pro Asp Asn 
    850                 855                 860                 


Arg Lys Asp Val Asp Glu Glu Ile Val Leu Leu Glu Glu Leu Glu Glu 
865                 870                 875                 880 


Leu Met Glu Leu Val Ser Tyr Thr Met Pro Ser Val Pro Glu Leu Ser 
                885                 890                 895     


Gly Lys Ala Glu Ser Gly Leu Asp Leu Val Ile Ser Lys Tyr Phe Lys 
            900                 905                 910         


Asp Phe Phe Glu Lys Ser Ala Leu Lys Asn Gln Asp Ile Met Lys Leu 
        915                 920                 925             


Tyr Tyr Gln Ser Asp Asn Lys Thr Pro Val Phe Arg Lys Tyr Met Ala 
    930                 935                 940                 


Leu Leu Met Arg Ser Ala Pro Leu Gln Leu Tyr Lys Asp Met Phe Arg 
945                 950                 955                 960 


Asn Tyr Tyr Ile Ile Thr Glu Lys Glu Cys Gln Glu Tyr Ile Lys Thr 
                965                 970                 975     


Ser Gln Asp Ile Asp Ala Phe Gln Cys Lys Leu Asn Glu Leu His Lys 
            980                 985                 990         


Glu Leu Glu His Val Arg Leu Lys  Thr Val Glu Asp Lys  Lys Gly Lys 
        995                 1000                 1005             


Ile Phe  Tyr Tyr Leu Ala Gly  Ser Asp Ala Glu Arg  Val Lys Glu 
    1010                 1015                 1020             


Tyr Glu  Asp Thr Leu Ser Lys  Val Val Arg Tyr Lys  Arg Leu Gln 
    1025                 1030                 1035             


His Lys  Leu Thr Phe Glu Ser  Leu Tyr Thr Ile Phe  Lys Ile His 
    1040                 1045                 1050             


Val Asp  Ile Ala Ala Arg Met  Val Gly Tyr Thr Glu  Asp Trp Glu 
    1055                 1060                 1065             


Arg Asp  Met Leu Phe Leu Phe  Lys Ser Leu Glu Tyr  Asn Glu Lys 
    1070                 1075                 1080             


Leu Asn  Glu Gly Val Val Glu  Lys Ile Phe Asn Asn  Lys Asp Glu 
    1085                 1090                 1095             


Lys Gly  His Ile Val Lys Lys  Leu Lys Asp Asn Leu  Asn Ser Glu 
    1100                 1105                 1110             


Asp Lys  Glu Lys Ile Gly Ile  Leu Cys Trp His Lys  Glu Ile Thr 
    1115                 1120                 1125             


Asp Lys  Asn Phe Val Glu Ile  Ile Trp Ile Arg Asn  Pro Ile Ala 
    1130                 1135                 1140             


His Leu  Asn His Phe Met Gln  Thr Val Lys Asn Pro  Lys Arg Ser 
    1145                 1150                 1155             


Leu Glu  Lys Met Ile Asn Ala  Leu Cys Val Leu Leu  Ser Tyr Asp 
    1160                 1165                 1170             


Arg Lys  Arg Gln Asn Ser Val  Thr Lys Thr Ile Asn  Asp Leu Leu 
    1175                 1180                 1185             


Leu Asn  Glu Tyr His Val Lys  Ile Lys Trp Lys Arg  Trp Val Asp 
    1190                 1195                 1200             


Lys Asn  Cys Asn Ile Tyr Tyr  Tyr Ile Asp Glu Gln  Asn Ile Glu 
    1205                 1210                 1215             


Asn Glu  Pro Ile Leu His Ile  Lys His Leu His Met  Gly Glu Lys 
    1220                 1225                 1230             


Cys His  Val Asn Arg Asn Ala  Asp Met Phe Asp Arg  Gln Lys Glu 
    1235                 1240                 1245             


Trp Leu  Arg Asn Gly Ile Thr  Glu Glu Val Tyr Asp  Lys Ser Met 
    1250                 1255                 1260             


Leu Gly  Cys Ile Cys Arg Leu  Phe Lys Phe Asp Tyr  Asn Asp Leu 
    1265                 1270                 1275             


Tyr Gly  Ala Asn Arg Gln 
    1280                 


<210>  64
<211>  1235
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  64

Met Lys Ile Thr Lys Arg Lys Trp Glu Asn Lys Pro Pro Val Phe Phe 
1               5                   10                  15      


Tyr Arg Asp Asp Glu Ser Gly Lys Leu Ile Thr Gln Gly Ser Arg His 
            20                  25                  30          


Asp Gln Thr Asp Ile Leu Phe Arg Glu Glu Ser Ser Val Ser Asp Val 
        35                  40                  45              


Phe Glu Lys Ser Leu Gln Asn Arg Leu Leu Lys Met Gln Lys Asp Gly 
    50                  55                  60                  


Lys Arg Ile Lys Lys Asn Glu Ile Thr Glu Leu Val Ala Cys Leu Cys 
65                  70                  75                  80  


Lys Ser Thr Gly Ser Arg Asn Asn Ala Cys Ile Glu Ser Ile Ile Asn 
                85                  90                  95      


Lys Ile Gln Lys Leu Ser Pro Gly Val Ala Thr Glu Lys Cys Asn Glu 
            100                 105                 110         


Thr Leu Ser Glu Tyr Gly Lys Cys Phe Ala Ala Glu Gly Ser Asn Met 
        115                 120                 125             


Thr Leu Tyr Lys Ala Leu Leu Tyr Leu Ile Asp Gly Asn Asp Ile Glu 
    130                 135                 140                 


Lys Ala Met Ala Lys Ala Gly Leu Val Lys Ile Gln Gln Ala Leu Gln 
145                 150                 155                 160 


Lys Glu Arg Glu Tyr Arg Lys Arg Arg Val Phe Asn Ser Ile Lys Lys 
                165                 170                 175     


Asn Lys Ile Pro Leu Ile Val Lys Asp Asp Gly Thr Ile Glu Ala Asn 
            180                 185                 190         


Asn Asp Arg Thr Ala Trp Leu Leu Glu Leu Leu Thr Pro Val Lys Ser 
        195                 200                 205             


Ser Ser Glu Asp His Asp Tyr Asp Phe Tyr Pro Val Leu Thr Glu Ile 
    210                 215                 220                 


Lys Lys Ile Ile Ser Tyr Glu Arg Leu Ser Asn Asp Ile Lys Lys Gln 
225                 230                 235                 240 


Ile Glu Gln Cys Asp Gly Lys Ala Arg Ser Ile Ala Lys Ala Ala Asp 
                245                 250                 255     


Glu Val Leu Lys Lys His Leu Lys Asp Leu Trp Glu Arg Tyr Pro Glu 
            260                 265                 270         


Asn His Arg Asn Met Lys Tyr Tyr Phe Gln Ala Val His Glu Tyr Phe 
        275                 280                 285             


Lys Asp Asn Phe Pro Ile Lys Ala Lys Met Ala Gly Ala Lys Lys Arg 
    290                 295                 300                 


Gln Glu Leu Leu Thr Lys Asp Lys Ala Ala Leu Leu Arg Leu Leu Glu 
305                 310                 315                 320 


Pro Asp His Ile Ala Lys Thr Val His Arg Lys Leu Ile Asn Gln Ser 
                325                 330                 335     


Thr Gln Met His Ile Leu Tyr Gly Lys Leu Tyr Glu Tyr Cys Cys Lys 
            340                 345                 350         


Gly Asp Asn Lys Leu Pro Val Asn Ser Asp Thr Leu Gln Leu Ile Gln 
        355                 360                 365             


Val Ser Glu Ala Val Lys Lys Gln Val Met Thr Ala Val Leu Trp Ser 
    370                 375                 380                 


Ile Ser Arg Leu Lys Tyr Phe Tyr Glu Tyr Tyr Asp Gly Asp Ile Leu 
385                 390                 395                 400 


Ser Glu His Glu Leu Val Lys Glu Tyr Arg Arg Lys Phe Leu Val Val 
                405                 410                 415     


Asn Lys Gln Tyr Thr Asn Asp Phe Val Gln Ala Cys Lys Glu Lys Ile 
            420                 425                 430         


Lys Tyr Phe Phe Pro Leu Glu Glu Ile Gln Glu Arg Tyr Gly Ala Gly 
        435                 440                 445             


Met Ser Ser Lys Tyr Ile Val Pro Ala Lys Met Ala Trp Asp Asp Arg 
    450                 455                 460                 


Glu Ile Cys Asn Lys Leu Leu Ala Glu Cys Val Phe Cys Val Asn Lys 
465                 470                 475                 480 


Leu Arg Thr Asn Ile Phe His Tyr Lys Asn Met Ser Leu Thr Gln Met 
                485                 490                 495     


Leu Lys Asn Met Ser Asp Glu Val Gly Lys Glu Leu Ile Glu Lys Gly 
            500                 505                 510         


Ser Ile Leu Leu Gln Leu Tyr Ile Asn Asp Val Glu Asn Arg Asn Lys 
        515                 520                 525             


Ala Phe Ala Gln Arg Ile Arg Ser Met Asn Leu Pro Leu Tyr Tyr Ser 
    530                 535                 540                 


Lys Asp Leu Leu Asn Arg Ile Phe Thr Lys Tyr Gly Ala Glu Phe Thr 
545                 550                 555                 560 


Leu Tyr Ser Pro Asn Asn Gln Met Thr Pro Ser Phe Arg Arg Val Tyr 
                565                 570                 575     


Glu Lys Gly Lys Asn Leu Arg Lys Glu Tyr Glu Arg Lys Phe Lys Ser 
            580                 585                 590         


Ala His Ser Arg Lys Gln Leu Asn Ser Glu Ser Glu Tyr Ile Leu Arg 
        595                 600                 605             


Trp Phe Arg Gln His Asp Tyr Ala Asp Glu Ala Ala Glu Ala Gly Thr 
    610                 615                 620                 


Arg Ser Val Ser Asn Ser Asp Ser Asp Ile Asp Ile Glu Thr Gly Ile 
625                 630                 635                 640 


Ile Asp Tyr Ile Asp Glu Ser Asn Glu Ile Asp Ser Asp Asp Tyr Ser 
                645                 650                 655     


Ser Glu Ser Glu Asn Ile Asn Asp Val Ser Lys Asp Ile Asp Thr Gln 
            660                 665                 670         


Arg Val Ile Arg Asn Leu Leu Gln Leu Ile Tyr Lys His Gln Phe Leu 
        675                 680                 685             


Pro Glu Val Leu Arg Asn Glu Thr Ile Val Thr Gly Lys Ile Arg Lys 
    690                 695                 700                 


Val Leu Asp Arg Asn Arg Met Ile Ala Asp Glu Arg Ser Lys Phe Ser 
705                 710                 715                 720 


Ala Ala Arg Asn Phe Gly Tyr Ser Ala Val Glu Glu Ile Tyr His Asp 
                725                 730                 735     


Gly Ile Thr Leu Ala Glu Leu Leu Lys Glu Leu Gln Arg Lys Ile Ser 
            740                 745                 750         


Glu Thr Glu Lys Glu Asn Lys Glu Leu Glu Arg Ser Lys Thr Asp Tyr 
        755                 760                 765             


Val Gln Arg Phe Ile Arg Glu Leu Phe Ala Val Ala Phe Glu Ser Phe 
    770                 775                 780                 


Met Asn Glu Gln Tyr Gly Glu Val Tyr Asp Glu Ile Met His Pro Lys 
785                 790                 795                 800 


Arg Asn Glu Asp Glu Ala Lys Lys Trp Ser Glu Glu Ser Val Lys Leu 
                805                 810                 815     


Gly Thr Ser Leu Asn Glu Ser Lys Thr Glu Gly Tyr Leu Leu Val Phe 
            820                 825                 830         


Tyr Thr Val Met Arg Leu Leu Asp Glu Asn Glu Leu Ser Glu Leu Gln 
        835                 840                 845             


Gln Gln Met Leu Arg Tyr Arg Ala Ser Met Ser Arg Trp Asn Gly Glu 
    850                 855                 860                 


Thr Asp Phe Asp Glu Asp Val Lys Ile Ile Glu Lys Ile Glu Glu Leu 
865                 870                 875                 880 


Ala Glu Leu Val Lys Leu Thr Glu Pro Val Pro Ser Asn Thr Glu Val 
                885                 890                 895     


Trp Asn Lys Arg Ile Lys Glu Glu Ile Lys Gln Leu Ile Glu Gly Asp 
            900                 905                 910         


Leu Thr Asp Tyr Gly Glu Phe Tyr Leu Gln Ser Asp Lys Thr Ser Pro 
        915                 920                 925             


Val Leu Arg Arg Asn Met Met Arg Leu Ile Arg Ser Gly Ile Thr Glu 
    930                 935                 940                 


Val Tyr Lys Lys Val Leu His Asn Gln Lys Gln Ala Thr Arg Arg Asp 
945                 950                 955                 960 


Tyr Asp Val Tyr Cys Arg Ser Gln His Glu Asn Leu Pro Gly Ile Asn 
                965                 970                 975     


Ser Val Glu Gln Ala Gln Lys Val Leu Gln Gln Leu His Arg Thr Tyr 
            980                 985                 990         


Ala Val Ser Pro Ser Asn Phe Ser  Ala Asp Asp Tyr Arg  Lys Tyr Lys 
        995                 1000                 1005             


Asn Ile  Leu Gln Trp Leu Glu  Glu Tyr Asn Arg Ala  Val Arg Asn 
    1010                 1015                 1020             


Leu Ser  Phe Glu Thr Leu Tyr  Glu Val Cys Val Ile  Asn Met Glu 
    1025                 1030                 1035             


Ile Leu  Ser Arg Trp Ile Gly  Leu Ile Gln Asp Trp  Glu Arg Asp 
    1040                 1045                 1050             


Met Tyr  Phe Ile Leu Leu Ala  Trp Val Lys Gln Gly  Lys Leu Tyr 
    1055                 1060                 1065             


Gly Leu  Thr Glu Lys Asp Val  Thr Asp Ile Phe Glu  Arg Gly Arg 
    1070                 1075                 1080             


Val Val  Gly Arg Leu Lys Lys  Lys Leu Lys Gly Asn  Asn Met Ala 
    1085                 1090                 1095             


Ala Phe  Met Ser Ile Tyr Arg  Thr Glu Lys Asp Asp  Lys Asp Met 
    1100                 1105                 1110             


Glu Phe  Ala Glu Val Arg Asn  Arg Ile Ala His Leu  Glu Leu Leu 
    1115                 1120                 1125             


Arg Glu  Ser Gly Trp Ser Ile  Asp Thr Lys Asp Arg  Asp Leu Ser 
    1130                 1135                 1140             


Val Ile  Glu Trp Tyr Leu Asn  Lys Leu Arg Leu Leu  Leu Ser Tyr 
    1145                 1150                 1155             


Asp Gln  Lys Arg Met Asn Ala  Val Ser Ser Val Met  Lys Thr Ile 
    1160                 1165                 1170             


Phe Gln  Lys His Asn Thr Glu  Ala Val Phe Arg Ile  Glu Arg Gly 
    1175                 1180                 1185             


Gly Glu  Leu Lys Phe Asp Ser  Val Lys Pro Val Met  Ile Glu His 
    1190                 1195                 1200             


Leu Lys  Asp Ser Glu Phe Lys  Lys Gly Ile Asn Val  Pro Ser Arg 
    1205                 1210                 1215             


Gly Lys  Thr Phe Leu Asn Asp  Leu Glu Arg Leu Met  Lys Tyr Lys 
    1220                 1225                 1230             


Asp Ile  
    1235 


<210>  65
<211>  1225
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  65

Met Lys Ile Thr Lys Arg Lys Trp Gly Glu His His Pro Pro Leu Tyr 
1               5                   10                  15      


Phe Tyr Arg Asp Glu Asp Ser Gly Arg Leu Leu Ala Gln Asn Asp Arg 
            20                  25                  30          


Lys Gln Asp Tyr Thr Asp Thr Leu Phe Asn Asp Ile Ala Gln Asp Thr 
        35                  40                  45              


Phe Glu Arg Ser Leu Arg Asn Arg Leu Leu Lys Thr Pro Glu Lys Gly 
    50                  55                  60                  


Asp Lys Arg Phe Tyr Ser Asn Glu Ile Val Lys Leu Val Glu Lys Leu 
65                  70                  75                  80  


Cys Gln Gly Ala Asp Val Ala Glu Ile Met Lys Ser Met Glu Arg Ser 
                85                  90                  95      


Glu Lys Leu Arg Pro Lys Asn Glu Lys Glu Ile Lys Asn Leu Lys Lys 
            100                 105                 110         


Gln Leu Asp Gly Thr Leu Ser Glu Tyr Gly Lys Arg Tyr Thr Ala Pro 
        115                 120                 125             


Glu Gly Ala Met Thr Leu Asn Asp Ala Leu Phe Tyr Leu Val Glu Gly 
    130                 135                 140                 


Asn Pro Leu Lys Gln Ala Met Ala Lys Ala Glu Leu Gly Lys Ile Arg 
145                 150                 155                 160 


Glu Ala Leu Ile Lys Glu Lys Glu Asn Arg Ile Asn Arg Val Arg Tyr 
                165                 170                 175     


Ser Ile Lys Asn Asn Lys Ile Pro Leu Arg Ile Gln Gly Asp Gly Gly 
            180                 185                 190         


Ile Thr Pro Asn Asn Asp Arg Ala Ala Trp Leu Leu Gly Leu Met Lys 
        195                 200                 205             


Pro Ala Asp Pro Ala Lys Gly Ile Thr Asp Cys Tyr Pro Leu Leu Gly 
    210                 215                 220                 


Glu Leu Glu Glu Val Phe Asp Phe Asp Lys Leu Ser Lys Thr Leu His 
225                 230                 235                 240 


Glu Lys Ile Ser Arg Cys Gln Gly Arg Pro Arg Ser Ile Ala Met Ala 
                245                 250                 255     


Val Asp Glu Ala Leu Lys Gln Tyr Leu Arg Glu Leu Trp Glu Lys Ser 
            260                 265                 270         


Pro Ser Arg Gln Gln Asp Leu Lys Tyr Tyr Phe Gln Ala Val Gln Glu 
        275                 280                 285             


Tyr Phe Lys Asp Asn Phe Pro Ile Arg Thr Lys Arg Met Gly Ala Arg 
    290                 295                 300                 


Leu Arg Gln Glu Leu Leu Lys Asp Lys Thr Ser Leu Ser Arg Leu Leu 
305                 310                 315                 320 


Glu Pro Lys His Met Ala Asn Ala Val Arg Arg Arg Leu Ile Asn Gln 
                325                 330                 335     


Ser Thr Gln Met His Ile Leu Tyr Gly Lys Leu Tyr Ala Tyr Cys Cys 
            340                 345                 350         


Gly Glu Asp Gly Arg Leu Leu Val Asn Ser Glu Thr Leu Gln Arg Ile 
        355                 360                 365             


Gln Val His Glu Ala Val Lys Lys Gln Ala Met Thr Ala Val Leu Trp 
    370                 375                 380                 


Ser Ile Ser Arg Leu Arg Tyr Phe Tyr Gln Phe Glu Asp Gly Asp Ile 
385                 390                 395                 400 


Leu Ser Asn Lys Asn Pro Ile Lys Asp Phe Arg Asp Lys Phe Leu Arg 
                405                 410                 415     


Asp Thr Asn Lys Tyr Thr His Glu Asp Val Glu Ala Cys Lys Glu Lys 
            420                 425                 430         


Leu Gln Asp Phe Phe Pro Leu Lys Glu Leu Gln Glu Lys Ile Lys Glu 
        435                 440                 445             


Asp Ala Lys Gly Leu Gln Glu Thr Asp Asn Lys Gln Ala Asp Thr Thr 
    450                 455                 460                 


Asp Phe Lys Ala Ile Gly His Ile Val Arg Asp Asp Arg Lys Leu Cys 
465                 470                 475                 480 


Asn Gln Leu Leu Ala Glu Cys Val Ser Cys Ile Gly Glu Leu Arg His 
                485                 490                 495     


His Ile Phe His Tyr Lys Asn Val Thr Leu Ile Gln Ala Leu Lys Arg 
            500                 505                 510         


Ile Ala Asp Lys Val Lys Pro Glu Asp Leu Ser Val Leu Arg Ala Ile 
        515                 520                 525             


Tyr Leu Leu Asp Arg Arg Asn Leu Lys Lys Ala Phe Ala Lys Arg Ile 
    530                 535                 540                 


Ser Ser Met Asn Leu Pro Leu Tyr Tyr Arg Glu Asp Leu Leu Ser Arg 
545                 550                 555                 560 


Ile Phe Lys Lys Glu Gly Thr Ala Phe Phe Leu Tyr Ser Ala Lys Ile 
                565                 570                 575     


Gln Met Thr Pro Ser Phe Gln Arg Val Tyr Glu Arg Gly Lys Asn Leu 
            580                 585                 590         


Arg Arg Glu Phe Glu Cys Glu Arg Met Lys Ala Glu Ala Ser Asn Gly 
        595                 600                 605             


Gln Asn Gly Gln Asp Gly Asp Arg Leu Lys Trp Phe Arg Gln Leu Ala 
    610                 615                 620                 


Ala Gly Asp Ser Ala Asp Thr His Phe Asn Trp Ala Val Glu Ala Tyr 
625                 630                 635                 640 


Ala Glu Ser Ala Ala Asp Val Glu Asn Asn Val Glu Phe Asp Thr Asp 
                645                 650                 655     


Val Asp Ala Gln Arg Ala Leu Arg Asn Leu Leu Leu Leu Ile Tyr Arg 
            660                 665                 670         


His His Phe Leu Pro Glu Val Gln Lys Asp Glu Thr Leu Val Thr Gly 
        675                 680                 685             


Lys Ile His Lys Val Leu Glu Arg Asn Arg Gln Leu Ser Glu Gly Gln 
    690                 695                 700                 


Gly Pro Asn Gln Gly Lys Ala His Gly Tyr Ser Val Ile Glu Glu Leu 
705                 710                 715                 720 


Tyr His Glu Gly Met Pro Leu Ser Asp Leu Met Lys Gln Leu Gln Arg 
                725                 730                 735     


Arg Ile Ser Glu Thr Glu Arg Glu Ser Arg Glu Leu Ala Gln Glu Lys 
            740                 745                 750         


Thr Asp Tyr Ala Gln Arg Phe Ile Leu Asp Ile Phe Ala Glu Ala Phe 
        755                 760                 765             


Asn Asp Phe Leu Glu Ala His Tyr Gly Glu Glu Tyr Leu Glu Ile Met 
    770                 775                 780                 


Ser Pro Arg Lys Asp Ala Glu Ala Ala Lys Lys Trp Val Lys Glu Ser 
785                 790                 795                 800 


Lys Thr Val Asp Leu Lys Thr Ser Ile Asp Glu Lys Glu Pro Glu Gly 
                805                 810                 815     


His Leu Leu Val Leu Tyr Pro Val Leu Arg Leu Leu Asp Glu Arg Glu 
            820                 825                 830         


Leu Gly Glu Leu Gln Gln Gln Met Ile Arg Tyr Arg Thr Ser Leu Ala 
        835                 840                 845             


Ser Trp Gln Gly Glu Ser Asn Phe Ser Glu Glu Ile Arg Ile Ala Gly 
    850                 855                 860                 


Gln Ile Glu Glu Leu Thr Glu Leu Val Lys Leu Thr Glu Pro Glu Pro 
865                 870                 875                 880 


Gln Phe Ala Glu Glu Val Trp Gly Lys Arg Ala Lys Glu Ala Phe Glu 
                885                 890                 895     


Asp Phe Ile Glu Gly Asn Met Lys Asn Tyr Glu Ala Phe Tyr Leu Gln 
            900                 905                 910         


Ser Asp Asn Asn Thr Pro Val Tyr Arg Arg Asn Met Ser Arg Leu Leu 
        915                 920                 925             


Arg Ser Gly Leu Met Gly Val Tyr Gln Lys Val Leu Ala Ser His Lys 
    930                 935                 940                 


Gln Ala Leu Lys Arg Asp Tyr Leu Leu Trp Ser Glu Lys His Trp Asn 
945                 950                 955                 960 


Val Lys Asp Glu Asn Gly Ala Asp Ile Ser Ser Ala Glu Gln Ala Gln 
                965                 970                 975     


Cys Leu Leu Gln Arg Leu His Arg Lys Tyr Ala Glu Ser Pro Ser Arg 
            980                 985                 990         


Phe Thr Glu Glu Asp Cys Lys Leu  Tyr Glu Lys Val Leu  Arg Arg Leu 
        995                 1000                 1005             


Glu Asp  Tyr Asn Gln Ala Val  Lys Asn Leu Ser Phe  Ser Ser Leu 
    1010                 1015                 1020             


Tyr Glu  Ile Cys Val Leu Asn  Leu Glu Ile Leu Ser  Arg Trp Val 
    1025                 1030                 1035             


Gly Phe  Val Gln Asp Trp Glu  Arg Asp Met Tyr Phe  Leu Leu Leu 
    1040                 1045                 1050             


Ala Trp  Val Arg Gln Gly Lys  Leu Asp Gly Ile Lys  Glu Glu Asp 
    1055                 1060                 1065             


Val Arg  Asp Ile Phe Ser Glu  Gly Asn Ile Ile Arg  Asn Leu Val 
    1070                 1075                 1080             


Asp Thr  Leu Lys Gly Glu Asn  Met Asn Ala Phe Glu  Ser Val Tyr 
    1085                 1090                 1095             


Phe Pro  Glu Asn Lys Gly Ser  Lys Tyr Leu Gly Val  Arg Asn Asp 
    1100                 1105                 1110             


Val Ala  His Leu Asp Leu Met  Arg Lys Asn Gly Trp  Arg Leu Glu 
    1115                 1120                 1125             


Ala Gly  Lys Thr Cys Ser Val  Met Glu Asp Tyr Ile  Asn Arg Leu 
    1130                 1135                 1140             


Arg Phe  Leu Leu Ser Tyr Asp  Gln Lys Arg Met Asn  Ala Val Thr 
    1145                 1150                 1155             


Lys Thr  Leu Gln Gln Ile Phe  Asp Arg His Lys Val  Lys Ile Arg 
    1160                 1165                 1170             


Phe Thr  Val Glu Lys Gly Gly  Met Leu Lys Ile Glu  Asp Val Thr 
    1175                 1180                 1185             


Ala Asp  Lys Ile Ala His Leu  Lys Gly Ser Arg Leu  Ser Gly Ile 
    1190                 1195                 1200             


Glu Ile  Pro Ser His Gly Glu  Arg Phe Ile Asp Thr  Leu Lys Ala 
    1205                 1210                 1215             


Leu Met  Val Tyr Pro Arg Gly  
    1220                 1225 


<210>  66
<211>  1276
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  66

Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn Ala 
1               5                   10                  15      


Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Arg Arg Val Glu 
            20                  25                  30          


Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys Met 
        35                  40                  45              


Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe Pro 
    50                  55                  60                  


Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser Lys 
65                  70                  75                  80  


Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys Leu 
                85                  90                  95      


Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg Met 
            100                 105                 110         


Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu Tyr 
        115                 120                 125             


Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe Glu 
    130                 135                 140                 


Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile Val 
145                 150                 155                 160 


Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys Asp 
                165                 170                 175     


Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys Lys 
            180                 185                 190         


Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys Glu 
        195                 200                 205             


Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr Leu 
    210                 215                 220                 


Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp Met 
225                 230                 235                 240 


Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu Asn 
                245                 250                 255     


Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn Leu 
            260                 265                 270         


Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala Val 
        275                 280                 285             


Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile Arg 
    290                 295                 300                 


Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr Ile 
305                 310                 315                 320 


Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp Gly 
                325                 330                 335     


Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu Trp 
            340                 345                 350         


Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val Tyr 
        355                 360                 365             


His Phe Ala Ile Pro Asp Leu Ser Gly Ala Leu Glu Gly Glu Ser Val 
    370                 375                 380                 


Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly Phe 
385                 390                 395                 400 


Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met Glu 
                405                 410                 415     


Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr Pro 
            420                 425                 430         


Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met Lys 
        435                 440                 445             


Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln Lys 
    450                 455                 460                 


Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp Ala 
465                 470                 475                 480 


Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg Glu 
                485                 490                 495     


Lys Glu Asp Ser Leu Val Asn Leu Tyr Ser Gly Glu Asp Leu Tyr Lys 
            500                 505                 510         


Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His Tyr 
        515                 520                 525             


Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala Glu 
    530                 535                 540                 


Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg Glu 
545                 550                 555                 560 


Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val Ile 
                565                 570                 575     


Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala Ala 
            580                 585                 590         


Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro Gln 
        595                 600                 605             


Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met Asn 
    610                 615                 620                 


Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe Phe 
625                 630                 635                 640 


Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys Lys 
                645                 650                 655     


Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Lys Lys Leu 
            660                 665                 670         


Ser Arg Gln Glu Lys Gly Asp Lys Glu Gln Lys Ala Trp Glu Ser Phe 
        675                 680                 685             


Glu Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala Ile 
    690                 695                 700                 


Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile Ser 
705                 710                 715                 720 


Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys Gln 
                725                 730                 735     


Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu Ala 
            740                 745                 750         


Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Gly Leu Arg Thr Pro Val 
        755                 760                 765             


Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp Gly 
    770                 775                 780                 


Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Glu Thr Phe Asn Asp 
785                 790                 795                 800 


Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn Gln 
                805                 810                 815     


Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln Phe 
            820                 825                 830         


Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val Asp 
        835                 840                 845             


Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Val Glu Ile 
    850                 855                 860                 


Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met Glu 
865                 870                 875                 880 


Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly Phe 
                885                 890                 895     


Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala Leu 
            900                 905                 910         


Tyr Ser Phe Cys Lys Gln Lys Phe Lys Val Asp Gly Lys Glu Tyr Met 
        915                 920                 925             


Ala Gly Ile Tyr Tyr Asp Gly Glu Asn Leu Ile Pro Asn Arg Asn Ile 
    930                 935                 940                 


Ile Arg Ala Asn Met Tyr Gly Thr Thr Ser Cys Leu Lys Pro Cys Met 
945                 950                 955                 960 


Asp Arg Ile Thr Leu Lys Glu Ile Arg Thr Met Tyr Ala Asp Gln Asn 
                965                 970                 975     


Lys Leu Asp Leu Val Leu Lys Glu Gly Val Cys His Thr Glu Glu Glu 
            980                 985                 990         


Gln Lys Ala Tyr Arg Glu Tyr Gln  Asn Glu Lys Asn Arg  Ile Glu Leu 
        995                 1000                 1005             


Phe Asp  Val Cys Thr Tyr Thr  Gln Ile Leu Asn Asp  Met Gln Ala 
    1010                 1015                 1020             


Arg Leu  Ile Gly Trp Ser Tyr  Met Arg Glu Arg Asp  Leu Met Tyr 
    1025                 1030                 1035             


Tyr Gln  Leu Gly Tyr Tyr Tyr  Thr Lys Leu Phe Trp  Thr Asp Ser 
    1040                 1045                 1050             


Ile Ser  Glu Glu Asp Ala Arg  Arg Arg Leu Val Gly  Asn Leu Val 
    1055                 1060                 1065             


Asn Val  Glu Asp Gly Ala Ile  Leu Tyr Gln Ile Leu  Ala Phe Asn 
    1070                 1075                 1080             


Ser Tyr  Asn Leu Pro Ile Ile  Ala Asn Lys Asn Asn  Thr Val Thr 
    1085                 1090                 1095             


Leu Leu  Lys Asp Glu Gly Ser  Ile Gly Gly Lys Ala  Ile Thr Ala 
    1100                 1105                 1110             


Phe Phe  Lys Asn Tyr Glu Asn  Ala Glu Met Ile Tyr  Glu Glu Ala 
    1115                 1120                 1125             


Leu Asp  Leu Phe Glu Asn Met  Asp Glu His Ala Ala  Ile Ile Asn 
    1130                 1135                 1140             


Thr Arg  Asn Tyr Ile Glu His  Phe Lys Tyr Phe Ile  Lys Ser Asp 
    1145                 1150                 1155             


Arg Ser  Met Met Asp Leu Tyr  Ser Glu Ile Tyr Asp  Arg Phe Phe 
    1160                 1165                 1170             


Arg His  Asp His Asn Arg Lys  Lys Asn Val Pro Asp  Ser Leu Lys 
    1175                 1180                 1185             


Asn Val  Leu Ala Asp Asn Phe  Met Ile Val Asp Ile  Asp Met Glu 
    1190                 1195                 1200             


Leu Gly  Ser Lys Lys Val Gly  Glu Lys Lys Lys Gly  Phe Arg Glu 
    1205                 1210                 1215             


His Lys  Ala Ala Arg Ile Glu  Phe Thr Asp Ser Gly  Ile Arg Ser 
    1220                 1225                 1230             


Thr Asp  Met Thr Tyr Thr Ile  Lys Pro Asp Ile Lys  Asp Asn Lys 
    1235                 1240                 1245             


Lys Val  Leu Val Pro Ala Arg  Ser Glu Val Phe Leu  Lys Gln Phe 
    1250                 1255                 1260             


Arg Lys  Ile Leu Glu Tyr Arg  Ile Gln Asp Lys Thr  Gln 
    1265                 1270                 1275     


<210>  67
<211>  1432
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  67

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Ser Gly Ile Ser 
1               5                   10                  15      


Val Phe Glu Asn Lys Ser Glu Glu Gln Phe Ser Lys Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Arg Lys Asn Gly Lys Val Arg Leu Lys Ser Asn Asp 
        35                  40                  45              


Leu Arg Lys His Val Met Asp Cys Asn Lys Asn Ala Gln Asn Leu Tyr 
    50                  55                  60                  


Asn Val Ile Asn Pro Glu Phe Asp Phe Cys Lys Asp Lys Asn Arg Lys 
65                  70                  75                  80  


Lys Val Phe Glu Asp Leu Ala Lys Asn Phe Asn Leu Val Leu Cys Ser 
                85                  90                  95      


Ala Leu Arg Ser Val Asp Thr Ser Ile Ser Asp Pro Lys Glu Arg Ala 
            100                 105                 110         


Lys Glu Glu Thr Ala Phe Ile Leu Asn Met Asp Lys Glu Gly Ile Lys 
        115                 120                 125             


Thr Lys Lys Asp Ser Met Lys Ser Glu Asp Leu Ile Val Glu Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Asp Asn Gly Thr Glu Lys Thr Lys Lys Ala Glu Ser 
145                 150                 155                 160 


Pro Glu Leu Lys Glu Gln Arg Arg Lys Glu Gln Glu Ala Glu Ile Leu 
                165                 170                 175     


Lys Met Thr Glu Glu Leu Val Leu Arg Lys Leu Lys Lys Thr Leu Arg 
            180                 185                 190         


Arg Asn Ala Thr Leu Asp Asp Glu Ser Lys Met Gln Met Thr Glu Ile 
        195                 200                 205             


Ala Ile Ser Leu Met Lys Ala Ile Cys Val His Gly Asn Ala Gly Ser 
    210                 215                 220                 


Phe Asp Pro Val Ile Leu Lys Ala Phe Phe Lys Glu Ile Asp Lys Asp 
225                 230                 235                 240 


Tyr Met Lys Asn Glu Gln Met Glu Glu Ile Val Arg Ser Ile Glu Ser 
                245                 250                 255     


Gln Ser Val Lys Val Lys Val Ala Glu Lys Asp Gly Lys Tyr Leu Leu 
            260                 265                 270         


Leu Pro Ala Asn Ala Asp His Arg Lys Lys Lys Tyr Ala Phe Glu Phe 
        275                 280                 285             


Met Arg Lys Tyr Ala Ala Ala Glu Ala Glu Gly Lys Gln Glu Leu Thr 
    290                 295                 300                 


Glu His Ile Gln Ala Leu Ile Gly Leu Tyr Leu Cys Gly Glu Ser Glu 
305                 310                 315                 320 


Tyr Gln Asp Ala Lys Asn Cys Phe Tyr Asp Met Val Glu Asn His Glu 
                325                 330                 335     


Cys Met Ser Gly Glu Ile Glu Glu Ile Tyr Asn Thr Ile Lys Glu Leu 
            340                 345                 350         


Lys Asn Leu Ser Arg Gln Lys Arg Glu Glu Arg Lys Glu Ile Lys Glu 
        355                 360                 365             


Lys Ile Arg Glu Ile Glu Lys Ser Gly Lys Gly Asp Lys Arg Ile Pro 
    370                 375                 380                 


Asn Asn Asn Ser Asn Lys Ser Cys Lys Asn Asp Lys Lys Asp Asn Asp 
385                 390                 395                 400 


Asn Lys Glu Asn Asp Ile Asn Leu Asn Glu Asn Asp Leu Lys Lys Ala 
                405                 410                 415     


Ile Glu Glu Ile Asp Lys Glu Leu Ala Lys Ile Pro Leu Glu Ile Cys 
            420                 425                 430         


Ile Asn Asn Glu Lys Leu Asn Asn Ala Val Ile Lys Thr Met Ser Val 
        435                 440                 445             


Lys Tyr Arg Ala Ala Val Lys Tyr Leu Val Ser Lys Val Lys Lys Thr 
    450                 455                 460                 


Val Leu Gly Glu Ile Lys Glu Lys Lys Asp Cys Ser Cys Ala Asp Leu 
465                 470                 475                 480 


Tyr Trp Ile Asp Tyr Ile Asp Asn Thr Val Lys Lys Leu Leu Leu Asp 
                485                 490                 495     


Ser Arg Asn Lys Gly Met Tyr Arg Tyr Glu Ile Ser Phe Leu Ser Asn 
            500                 505                 510         


His Ile Trp Lys Glu Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu 
        515                 520                 525             


Leu Gly Lys Gly Val Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Ala 
    530                 535                 540                 


Leu Glu Gly Lys Pro Val Ser Val Cys Glu Val Lys Pro Glu Tyr Arg 
545                 550                 555                 560 


Lys Gly Ile Ser Gly Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Ser 
                565                 570                 575     


Leu Asp Arg Glu Met Glu Glu Tyr Val Leu Phe Ala Val Asn Asn Phe 
            580                 585                 590         


Ala Arg Ala Ala Ala Pro Glu Asn Glu Arg Glu Lys Pro Gly His Glu 
        595                 600                 605             


Asp Val Leu Ile Met Lys Thr Ser Asp Glu Leu Ile Ala Glu Asn Lys 
    610                 615                 620                 


Lys Asn Gln Glu Pro Ile Val Leu Tyr Lys Asp Ala Asp Arg Arg Ile 
625                 630                 635                 640 


Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg Glu Lys Glu Asp Ser 
                645                 650                 655     


Phe Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr Lys Glu Ile Arg Asn 
            660                 665                 670         


Glu Leu Tyr Thr Val Arg Asn Ile Thr Phe His Tyr Thr Thr Lys Ala 
        675                 680                 685             


Glu Lys Gly Gln Ile Gln Lys His Glu Met Ala Glu Tyr Phe Phe Glu 
    690                 695                 700                 


Glu Glu Leu Ala Asp Ile Ser Gly Val Phe Arg Lys Lys Tyr Tyr Ser 
705                 710                 715                 720 


Asn Asn Val Trp Lys Phe Tyr Asp Met Glu Val Ile Asn Asp Leu Met 
                725                 730                 735     


Asp Lys Ile Tyr Ser Gly Arg Lys Tyr Arg Ala Ala Gln Ile Pro Ala 
            740                 745                 750         


Phe Asn Asn Ile Ile Ser Arg Pro Ala Leu Pro Gln Ile Ile Asn Gly 
        755                 760                 765             


Phe Val Lys Gly Asn Ser Leu Lys Lys Ile Met Asn Tyr Pro Asp Arg 
    770                 775                 780                 


Glu Ile Ile Lys Gln Tyr Trp Ser Ala Leu Phe Phe Val Leu Lys Glu 
785                 790                 795                 800 


Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Glu Asn Pro Glu Glu Asn 
                805                 810                 815     


Ile Arg Glu Arg Phe Leu Arg Val Leu Ala Arg Lys Leu Glu Glu Thr 
            820                 825                 830         


Ser Asp Ala Lys Glu Gln Lys Ala Trp Glu Ser Phe Asp Lys Arg Ile 
        835                 840                 845             


Ser Glu Ile Gly Arg Lys Arg Ser Phe Gly Glu Ile Cys Gln Gly Leu 
    850                 855                 860                 


Met Ile Glu Tyr Met Leu Gln Asn Asn Asp Ser Pro Met Val Arg Lys 
865                 870                 875                 880 


Glu Asn Ile His Lys Arg Thr Gln Ser Arg Asp Thr Gln Ile Tyr Lys 
                885                 890                 895     


His Tyr Arg Thr Leu Leu Tyr Ile Cys Ile Arg Asp Ala Phe Ile Glu 
            900                 905                 910         


Tyr Leu Lys Glu Lys Trp Gln Gly Leu Arg Glu Pro Val Leu Ile Lys 
        915                 920                 925             


Lys Glu Trp Ser Glu Glu Glu Phe Cys His Ser Asp Asn Val Glu His 
    930                 935                 940                 


Leu Ser Leu Tyr Asp His Leu Lys Asp Leu Phe His Ser Thr Ala Ser 
945                 950                 955                 960 


Gly Pro Ser Trp Tyr Ile Ala Ala His Phe Ile Asn Pro Lys Tyr Leu 
                965                 970                 975     


Asn His Leu Ile Gly Ser Ile Arg Asn Tyr Leu Gln Phe Thr Glu Asp 
            980                 985                 990         


Ile Glu Arg Arg Ala Val Ser Leu  Gly Lys Cys Val Asp  Asn Glu Arg 
        995                 1000                 1005             


Glu Glu  Lys Asn Leu Arg Tyr  Arg Asn Thr Leu Glu  Ile Leu Glu 
    1010                 1015                 1020             


Phe Val  Leu Gln Phe Cys Gly  Lys Thr Thr Lys Val  Met Glu Asp 
    1025                 1030                 1035             


Tyr Phe  Glu Ser Asn Glu Val  Tyr Ala Ala Tyr Leu  Ser Asp Phe 
    1040                 1045                 1050             


Val Asp  Tyr Lys Thr Pro Lys  Asn Ile Thr Asp Ile  Glu Thr Ala 
    1055                 1060                 1065             


Leu His  Ile Phe Cys Glu Gln  Lys Val Asn Val Asp  Gly Lys Glu 
    1070                 1075                 1080             


Ser Met  Val Gly Ile Tyr Tyr  Asp Gly Gly Asn Leu  Ile Pro Asn 
    1085                 1090                 1095             


Arg Asn  Ile Ile Arg Ala Asn  Met Tyr Gly Asn Val  Ser Cys Leu 
    1100                 1105                 1110             


Lys Ala  Ser Met Asp Lys Ile  Lys Tyr Ala Glu Ile  Arg Lys Met 
    1115                 1120                 1125             


Tyr Ile  Asp Lys Ser Lys Leu  Asp Ser Val Leu Lys  Glu Gly Val 
    1130                 1135                 1140             


Cys Arg  Thr Lys Glu Asp Gln  Lys Ala Leu Lys Glu  Phe Gln Asn 
    1145                 1150                 1155             


Glu Lys  Asn Arg Ile Glu Leu  Leu Asp Leu Ser Thr  Tyr Thr Glu 
    1160                 1165                 1170             


Ile Leu  Asn Asp Met Gln Ala  Ile Leu Ile Gly Trp  Thr Tyr Met 
    1175                 1180                 1185             


Arg Glu  Arg Asp Leu Met Tyr  Tyr Gln Leu Gly Tyr  Tyr Tyr Thr 
    1190                 1195                 1200             


Lys Leu  Phe Trp Thr Asp Ser  Ile Ser Glu Glu Asp  Glu Leu Arg 
    1205                 1210                 1215             


Arg Leu  Thr Gly Asp Glu Val  Asn Ile Glu Asp Gly  Ala Ile Leu 
    1220                 1225                 1230             


Tyr Gln  Ile Leu Ala Phe Asn  Thr Tyr His Leu Pro  Val Ile Ser 
    1235                 1240                 1245             


Asn Lys  Lys Asn Thr Val Ser  Phe Val Lys Asp Asn  Gly Ser Ile 
    1250                 1255                 1260             


Gly Gly  Lys Ala Leu Arg Ala  Phe Phe Arg Asn Phe  Glu Asn Ala 
    1265                 1270                 1275             


Ile Pro  Ile Tyr Leu Glu Gly  Leu Asn Leu Phe Glu  Asn Thr Asp 
    1280                 1285                 1290             


Glu His  Asp Asp Ile Ile Asp  Thr Arg Asn Tyr Ile  Glu His Phe 
    1295                 1300                 1305             


Lys Tyr  Phe Ile Lys Ser Asp  Arg Ser Met Met Asp  Leu Tyr Ser 
    1310                 1315                 1320             


Glu Val  Tyr Asp Arg Phe Phe  Arg Tyr Asp His Lys  Leu Lys Lys 
    1325                 1330                 1335             


Ser Val  Pro Glu Val Leu Ile  Asn Val Leu Ala Arg  Asn Phe Met 
    1340                 1345                 1350             


Asp Ala  Arg Ile Tyr Met Lys  Leu Gly Ser Lys Gln  Val Val Lys 
    1355                 1360                 1365             


Glu Lys  Thr Gly Val Ser Arg  Glu His Lys Ala Ser  Lys Ile Ala 
    1370                 1375                 1380             


Phe Thr  Asp Lys Gly Ile Glu  Ser Thr Ala Leu Thr  Tyr Thr Ile 
    1385                 1390                 1395             


Lys Pro  Asp Ser Lys Asp Asn  Lys Lys Glu Ala Lys  Ile Leu Val 
    1400                 1405                 1410             


Asp Ala  Arg Ser Glu Val Phe  Leu Lys Gln Phe Gln  Lys Ile Leu 
    1415                 1420                 1425             


Glu Tyr  Arg Gly 
    1430         


<210>  68
<211>  1025
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  68

Met Leu Ser Phe Leu Ser Gly Lys Tyr Ile Ala Thr Gly Lys Ala Val 
1               5                   10                  15      


Trp His Phe Ala Met Lys Glu Gly Ile Glu Asp Glu Thr Lys Asp Leu 
            20                  25                  30          


Asn Leu Leu Arg Ile Arg Glu Asp Val Arg Arg Gly Leu Thr Ser Phe 
        35                  40                  45              


Asp Tyr Glu Gln Ile Lys Ala Glu Glu Val Leu Gln Arg Asp Met Ala 
    50                  55                  60                  


Val Tyr Val Ala Phe Ala Ser Asn His Leu Ser Ser Ala Thr Val Asp 
65                  70                  75                  80  


Leu Ser Ile Leu Asp Gly Glu Glu Gly Lys Glu Asp Phe Leu Leu Leu 
                85                  90                  95      


Lys Arg Glu Asp Leu Glu Lys Ser Arg Arg Pro Tyr Leu Arg Arg Asn 
            100                 105                 110         


Leu Leu Gln Phe Phe Gly Gly Glu Ser Thr Trp Gln Asp Phe Ser Phe 
        115                 120                 125             


Glu Lys Tyr Tyr Gln Glu Tyr Ser Ser Ala Asn Ser Thr Gln Tyr Asp 
    130                 135                 140                 


Asp Leu Ser Leu Leu Ser Asp Leu Gln Gln Ile Val Tyr Ala Ala Arg 
145                 150                 155                 160 


Asn Glu Ser Phe His Phe Asp Thr Arg Arg Arg Asn Pro Gly Asn Trp 
                165                 170                 175     


Asn Gln Ser Leu Ile Ser Ala Met Phe Ala His Asp Cys Lys Thr Ala 
            180                 185                 190         


Ser Thr Leu Gln Lys Glu Lys Phe Tyr Ser Asn Asn Leu Pro Met Phe 
        195                 200                 205             


Tyr Gly Glu Lys Asp Leu Leu Asp Leu Leu Arg Val Leu Tyr Gly Lys 
    210                 215                 220                 


Gln Thr Ala Arg Ala Ser Gln Val Pro Ser Phe Asn Lys Val Val Val 
225                 230                 235                 240 


Arg Arg Asn Phe Ser Asn Phe Ile Ser Asp Asn Leu Asn Trp Lys Asn 
                245                 250                 255     


Ile Asn Phe Thr Gly Glu Gly Ser Val Ala Leu Lys Glu Gln Phe Asp 
            260                 265                 270         


Ser Ala Leu Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Leu Phe Leu 
        275                 280                 285             


Gln Gly Arg Gly Ser Gly Ala Ala Phe Asp Val Lys Gly Glu Phe Ile 
    290                 295                 300                 


Lys Trp Cys Leu Asp Glu Lys Asn Gly Lys Gln Asn Ala Glu Ala Phe 
305                 310                 315                 320 


Lys Ser Phe Lys Ser Arg Val Glu Glu Ile Ile Ser Ser Lys Lys Asp 
                325                 330                 335     


Ile Thr Leu Pro Glu Ile Cys Gln Arg Ile Met Thr Asp Tyr Asn Ile 
            340                 345                 350         


Tyr Asn Asn Gly Thr Arg Lys Val Lys Ser Asp Ser Val Lys Gln Asn 
        355                 360                 365             


Met Pro Asp Ser Tyr Asp His Phe Lys Met Leu Leu Leu Lys Gly Leu 
    370                 375                 380                 


Arg Glu Val Phe Ala Ser Tyr Ile Cys Ala Glu Phe Val Val Leu Lys 
385                 390                 395                 400 


Asn Pro Arg Tyr Arg Glu Lys Pro Asp Ala Asp Ala Phe Leu Pro Asp 
                405                 410                 415     


Tyr Ser Ser Pro Thr Tyr Ser Thr Leu Ile Glu Arg Val Lys Gly Asn 
            420                 425                 430         


Pro Glu Leu Gln Lys Trp Tyr Val Val Gly Arg Leu Leu Asn Pro Arg 
        435                 440                 445             


Gln Ala Asn Phe Phe Val Gly Val Leu Arg Gln Tyr Ile Gln Tyr Thr 
    450                 455                 460                 


Gly Gln Ile Arg Arg Arg Ala Val Glu Thr Gly Ser Arg Met Val Asp 
465                 470                 475                 480 


Thr Ala Ser Ala Lys Ala Leu Lys Gly Tyr Ala Asn Val Leu Glu Val 
                485                 490                 495     


Cys Ile Gln Leu Ala Gly Met Thr Thr Asn Cys Leu Thr Asp Tyr Phe 
            500                 505                 510         


Asp Asp Lys Asp Asp Tyr Ala Arg His Ile Ser Arg Tyr Leu Asp Phe 
        515                 520                 525             


Glu Gly Ile Tyr Pro Gly Ile Ser Ile Ser Ala Gln Leu Glu Asn Phe 
    530                 535                 540                 


Cys Asn Glu Asn Ala Thr Asp Ile Asp Gln Ser Gly Val Ala Gly Ser 
545                 550                 555                 560 


Asn Ser Ala Asn Glu Ser Gly Ser Asp Glu Leu Lys Arg Leu Gly Val 
                565                 570                 575     


Phe Tyr Asp Ala Glu Asn Pro Ile Leu Asn Arg Asn Ile Leu Leu Ser 
            580                 585                 590         


Lys Ile Tyr Gly Thr Glu Lys Ile Leu Val Asn Ile Glu Lys Asn Arg 
        595                 600                 605             


Lys Ile Thr Arg Asp Glu Ile Arg Ala Phe Tyr Glu Gln Arg Glu Lys 
    610                 615                 620                 


Ile Gly Asp Tyr Arg Leu Thr Gly Lys Cys Ser Thr Glu Glu Gln Gln 
625                 630                 635                 640 


Arg Ala Leu Lys Lys Tyr Gln Glu Ile Lys Asn Arg Val Glu Phe Arg 
                645                 650                 655     


Asp Leu Val Glu Tyr Glu Glu Ile Val Asp Glu Met Gln Ala Gln Met 
            660                 665                 670         


Ile Asp Trp Cys Tyr Leu Arg Glu Arg Asp Leu Met Tyr Phe Gln Leu 
        675                 680                 685             


Gly Phe His Tyr Met Cys Leu Cys Asn Ser Ser Ser Lys Ala Glu Leu 
    690                 695                 700                 


Tyr Arg Gly Ile Glu Lys Asp Gly Arg Lys Ile Asp Gly Ala Ile Leu 
705                 710                 715                 720 


Tyr Gln Ile Ala Ala Met Tyr Ile Asn Gly Leu Pro Ile Tyr Ala Val 
                725                 730                 735     


Glu Lys Gly Lys Ile Lys Arg Lys Ser Glu Ser Met Ser Ala Gly Gly 
            740                 745                 750         


Lys Ile Arg Val Phe Leu Asn Tyr Ala Gly Ala Cys Val Glu Gln Ala 
        755                 760                 765             


Ala Ser Ser Lys Glu Ala Glu Ala Pro Ile Ser Ala Asp Ala Ala Glu 
    770                 775                 780                 


Arg Phe Tyr Leu Ala Gly Met Glu Leu Phe Glu Asn Thr Gln Glu His 
785                 790                 795                 800 


Asp Asn Ile Val Ala Leu Arg Asn Tyr Ile Glu His Phe His Tyr Tyr 
                805                 810                 815     


Val His Gln Asp Arg Ser Leu Leu Asp Leu Tyr Gly Glu Ile Phe Asp 
            820                 825                 830         


Arg Phe Phe Thr Tyr Asp Met Lys Tyr Gln Lys Asn Val Cys Asn Ile 
        835                 840                 845             


Leu Tyr Asn Ile Leu Met His His Phe Val Arg Pro Ala Phe Thr Phe 
    850                 855                 860                 


Ser Lys Ala Glu Lys Gln Val Gly Lys Ile Thr Lys Asp Arg Ala Ser 
865                 870                 875                 880 


Ile Ser Leu Val Glu Lys Lys Gly Leu Ser Ser Glu Lys Met Thr Tyr 
                885                 890                 895     


Lys Leu Ala Ser Pro Asn Lys Lys Gln Gln Gly Asn Thr Ser Ser Ala 
            900                 905                 910         


Asp Ile Gly Ser Ala Glu Glu Ala Lys Lys Met Asp Leu Pro Ala Lys 
        915                 920                 925             


Ser Arg Asp Phe Leu Glu Gly Val Ala Val Leu Leu Ser Tyr Pro Asp 
    930                 935                 940                 


Glu Pro Gly Asp Val Val Ser Glu Glu Arg His Asn Asn Arg Gln Ser 
945                 950                 955                 960 


Tyr Thr Thr Thr Lys Thr Glu Glu Asn Asp Asn Ser Arg Gly Lys Asp 
                965                 970                 975     


Gln Arg Arg Asn Asn Ser Gly Thr Gln Glu Thr Asn Trp Lys Gly Arg 
            980                 985                 990         


Gly Ala Asn Ala Asp Asn Arg Pro  Ser Gly Gly Gln Gly  Lys Ser Gly 
        995                 1000                 1005             


Ser Phe  Gly Thr Ser Leu Ala  Asp Leu Leu Lys Asp  Phe Lys Phe 
    1010                 1015                 1020             


Asp Glu  
    1025 


<210>  69
<211>  1182
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  69

Met Tyr Met Lys Ile Thr Lys Ile Asp Gly Val Ser His Tyr Lys Lys 
1               5                   10                  15      


Gln Asp Lys Gly Ile Leu Lys Lys Lys Trp Lys Asp Leu Asp Glu Arg 
            20                  25                  30          


Lys Gln Arg Glu Lys Ile Glu Ala Arg Tyr Asn Lys Gln Ile Glu Ser 
        35                  40                  45              


Lys Ile Tyr Lys Glu Phe Phe Arg Leu Lys Asn Lys Lys Arg Ile Glu 
    50                  55                  60                  


Lys Glu Glu Asp Gln Asn Ile Lys Ser Leu Tyr Phe Phe Ile Lys Glu 
65                  70                  75                  80  


Leu Tyr Leu Asn Glu Lys Asn Glu Glu Trp Glu Leu Lys Asn Ile Asn 
                85                  90                  95      


Leu Glu Ile Leu Asp Asp Lys Glu Arg Val Ile Lys Gly Tyr Lys Phe 
            100                 105                 110         


Lys Glu Asp Val Tyr Phe Phe Lys Glu Gly Tyr Lys Glu Tyr Tyr Leu 
        115                 120                 125             


Arg Ile Leu Phe Asn Asn Leu Ile Glu Lys Val Gln Asn Glu Asn Arg 
    130                 135                 140                 


Glu Lys Val Arg Lys Asn Lys Glu Phe Leu Asp Leu Lys Glu Ile Phe 
145                 150                 155                 160 


Lys Lys Tyr Lys Asn Arg Lys Ile Asp Leu Leu Leu Lys Ser Ile Asn 
                165                 170                 175     


Asn Asn Lys Ile Asn Leu Glu Tyr Lys Lys Glu Asn Val Asn Glu Glu 
            180                 185                 190         


Ile Tyr Gly Ile Asn Pro Thr Asn Asp Arg Glu Met Thr Phe Tyr Glu 
        195                 200                 205             


Leu Leu Lys Glu Ile Ile Glu Lys Lys Asp Glu Gln Lys Ser Ile Leu 
    210                 215                 220                 


Glu Glu Lys Leu Asp Asn Phe Asp Ile Thr Asn Phe Leu Glu Asn Ile 
225                 230                 235                 240 


Glu Lys Ile Phe Asn Glu Glu Thr Glu Ile Asn Ile Ile Lys Gly Lys 
                245                 250                 255     


Val Leu Asn Glu Leu Arg Glu Tyr Ile Lys Glu Lys Glu Glu Asn Asn 
            260                 265                 270         


Ser Asp Asn Lys Leu Lys Gln Ile Tyr Asn Leu Glu Leu Lys Lys Tyr 
        275                 280                 285             


Ile Glu Asn Asn Phe Ser Tyr Lys Lys Gln Lys Ser Lys Ser Lys Asn 
    290                 295                 300                 


Gly Lys Asn Asp Tyr Leu Tyr Leu Asn Phe Leu Lys Lys Ile Met Phe 
305                 310                 315                 320 


Ile Glu Glu Val Asp Glu Lys Lys Glu Ile Asn Lys Glu Lys Phe Lys 
                325                 330                 335     


Asn Lys Ile Asn Ser Asn Phe Lys Asn Leu Phe Val Gln His Ile Leu 
            340                 345                 350         


Asp Tyr Gly Lys Leu Leu Tyr Tyr Lys Glu Asn Asp Glu Tyr Ile Lys 
        355                 360                 365             


Asn Thr Gly Gln Leu Glu Thr Lys Asp Leu Glu Tyr Ile Lys Thr Lys 
    370                 375                 380                 


Glu Thr Leu Ile Arg Lys Met Ala Val Leu Val Ser Phe Ala Ala Asn 
385                 390                 395                 400 


Ser Tyr Tyr Asn Leu Phe Gly Arg Val Ser Gly Asp Ile Leu Gly Thr 
                405                 410                 415     


Glu Val Val Lys Ser Ser Lys Thr Asn Val Ile Lys Val Gly Ser His 
            420                 425                 430         


Ile Phe Lys Glu Lys Met Leu Asn Tyr Phe Phe Asp Phe Glu Ile Phe 
        435                 440                 445             


Asp Ala Asn Lys Ile Val Glu Ile Leu Glu Ser Ile Ser Tyr Ser Ile 
    450                 455                 460                 


Tyr Asn Val Arg Asn Gly Val Gly His Phe Asn Lys Leu Ile Leu Gly 
465                 470                 475                 480 


Lys Tyr Lys Lys Lys Asp Ile Asn Thr Asn Lys Arg Ile Glu Glu Asp 
                485                 490                 495     


Leu Asn Asn Asn Glu Glu Ile Lys Gly Tyr Phe Ile Lys Lys Arg Gly 
            500                 505                 510         


Glu Ile Glu Arg Lys Val Lys Glu Lys Phe Leu Ser Asn Asn Leu Gln 
        515                 520                 525             


Tyr Tyr Tyr Ser Lys Glu Lys Ile Glu Asn Tyr Phe Glu Val Tyr Glu 
    530                 535                 540                 


Phe Glu Ile Leu Lys Arg Lys Ile Pro Phe Ala Pro Asn Phe Lys Arg 
545                 550                 555                 560 


Ile Ile Lys Lys Gly Glu Asp Leu Phe Asn Asn Lys Asn Asn Lys Lys 
                565                 570                 575     


Tyr Glu Tyr Phe Lys Asn Phe Asp Lys Asn Ser Ala Glu Glu Lys Lys 
            580                 585                 590         


Glu Phe Leu Lys Thr Arg Asn Phe Leu Leu Lys Glu Leu Tyr Tyr Asn 
        595                 600                 605             


Asn Phe Tyr Lys Glu Phe Leu Ser Lys Lys Glu Glu Phe Glu Lys Ile 
    610                 615                 620                 


Val Leu Glu Val Lys Glu Glu Lys Lys Ser Arg Gly Asn Ile Asn Asn 
625                 630                 635                 640 


Lys Lys Ser Gly Val Ser Phe Gln Ser Ile Asp Asp Tyr Asp Thr Lys 
                645                 650                 655     


Ile Asn Ile Ser Asp Tyr Ile Ala Ser Ile His Lys Lys Glu Met Glu 
            660                 665                 670         


Arg Val Glu Lys Tyr Asn Glu Glu Lys Gln Lys Asp Thr Ala Lys Tyr 
        675                 680                 685             


Ile Arg Asp Phe Val Glu Glu Ile Phe Leu Thr Gly Phe Ile Asn Tyr 
    690                 695                 700                 


Leu Glu Lys Asp Lys Arg Leu His Phe Leu Lys Glu Glu Phe Ser Ile 
705                 710                 715                 720 


Leu Cys Asn Asn Asn Asn Asn Val Val Asp Phe Asn Ile Asn Ile Asn 
                725                 730                 735     


Glu Glu Lys Ile Lys Glu Phe Leu Lys Glu Asn Asp Ser Lys Thr Leu 
            740                 745                 750         


Asn Leu Tyr Leu Phe Phe Asn Met Ile Asp Ser Lys Arg Ile Ser Glu 
        755                 760                 765             


Phe Arg Asn Glu Leu Val Lys Tyr Lys Gln Phe Thr Lys Lys Arg Leu 
    770                 775                 780                 


Asp Glu Glu Lys Glu Phe Leu Gly Ile Lys Ile Glu Leu Tyr Glu Thr 
785                 790                 795                 800 


Leu Ile Glu Phe Val Ile Leu Thr Arg Glu Lys Leu Asp Thr Lys Lys 
                805                 810                 815     


Ser Glu Glu Ile Asp Ala Trp Leu Val Asp Lys Leu Tyr Val Lys Asp 
            820                 825                 830         


Ser Asn Glu Tyr Lys Glu Tyr Glu Glu Ile Leu Lys Leu Phe Val Asp 
        835                 840                 845             


Glu Lys Ile Leu Ser Ser Lys Glu Ala Pro Tyr Tyr Ala Thr Asp Asn 
    850                 855                 860                 


Lys Thr Pro Ile Leu Leu Ser Asn Phe Glu Lys Thr Arg Lys Tyr Gly 
865                 870                 875                 880 


Thr Gln Ser Phe Leu Ser Glu Ile Gln Ser Asn Tyr Lys Tyr Ser Lys 
                885                 890                 895     


Val Glu Lys Glu Asn Ile Glu Asp Tyr Asn Lys Lys Glu Glu Ile Glu 
            900                 905                 910         


Gln Lys Lys Lys Ser Asn Ile Glu Lys Leu Gln Asp Leu Lys Val Glu 
        915                 920                 925             


Leu His Lys Lys Trp Glu Gln Asn Lys Ile Thr Glu Lys Glu Ile Glu 
    930                 935                 940                 


Lys Tyr Asn Asn Thr Thr Arg Lys Ile Asn Glu Tyr Asn Tyr Leu Lys 
945                 950                 955                 960 


Asn Lys Glu Glu Leu Gln Asn Val Tyr Leu Leu His Glu Met Leu Ser 
                965                 970                 975     


Asp Leu Leu Ala Arg Asn Val Ala Phe Phe Asn Lys Trp Glu Arg Asp 
            980                 985                 990         


Phe Lys Phe Ile Val Ile Ala Ile  Lys Gln Phe Leu Arg  Glu Asn Asp 
        995                 1000                 1005             


Lys Glu  Lys Val Asn Glu Phe  Leu Asn Pro Pro Asp  Asn Ser Lys 
    1010                 1015                 1020             


Gly Lys  Lys Val Tyr Phe Ser  Val Ser Lys Tyr Lys  Asn Thr Val 
    1025                 1030                 1035             


Glu Asn  Ile Asp Gly Ile His  Lys Asn Phe Met Asn  Leu Ile Phe 
    1040                 1045                 1050             


Leu Asn  Asn Lys Phe Met Asn  Arg Lys Ile Asp Lys  Met Asn Cys 
    1055                 1060                 1065             


Ala Ile  Trp Val Tyr Phe Arg  Asn Tyr Ile Ala His  Phe Leu His 
    1070                 1075                 1080             


Leu His  Thr Lys Asn Glu Lys  Ile Ser Leu Ile Ser  Gln Met Asn 
    1085                 1090                 1095             


Leu Leu  Ile Lys Leu Phe Ser  Tyr Asp Lys Lys Val  Gln Asn His 
    1100                 1105                 1110             


Ile Leu  Lys Ser Thr Lys Thr  Leu Leu Glu Lys Tyr  Asn Ile Gln 
    1115                 1120                 1125             


Ile Asn  Phe Glu Ile Ser Asn  Asp Lys Asn Glu Val  Phe Lys Tyr 
    1130                 1135                 1140             


Lys Ile  Lys Asn Arg Leu Tyr  Ser Lys Lys Gly Lys  Met Leu Gly 
    1145                 1150                 1155             


Lys Asn  Asn Lys Phe Glu Ile  Leu Glu Asn Glu Phe  Leu Glu Asn 
    1160                 1165                 1170             


Val Lys  Ala Met Leu Glu Tyr  Ser Glu 
    1175                 1180         


<210>  70
<211>  1197
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  70

Met Lys Val Thr Lys Ile Asp Gly Leu Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Phe Arg Asn Asn Lys Asn Ile Asn Glu Ile 
            20                  25                  30          


Lys Glu Arg Leu Lys Lys Leu Lys Glu Leu Lys Leu Asp Asn Tyr Ile 
        35                  40                  45              


Lys Asn Pro Glu Asn Val Lys Asn Lys Asp Lys Asp Ala Glu Lys Glu 
    50                  55                  60                  


Thr Lys Ile Arg Arg Thr Asn Leu Lys Lys Tyr Phe Ser Glu Ile Ile 
65                  70                  75                  80  


Leu Arg Lys Glu Asp Glu Lys Tyr Ile Leu Lys Lys Thr Lys Lys Phe 
                85                  90                  95      


Lys Asp Ile Asn Gln Glu Ile Asp Tyr Tyr Asp Val Lys Ser Lys Lys 
            100                 105                 110         


Asn Gln Gln Glu Ile Phe Asp Val Leu Lys Glu Ile Leu Glu Leu Lys 
        115                 120                 125             


Ile Lys Glu Thr Glu Lys Glu Glu Ile Ile Thr Phe Asp Ser Glu Lys 
    130                 135                 140                 


Leu Lys Lys Val Phe Gly Glu Asp Phe Val Lys Lys Glu Ala Lys Ile 
145                 150                 155                 160 


Lys Ala Ile Glu Lys Ser Leu Lys Ile Asn Lys Ala Asn Tyr Lys Lys 
                165                 170                 175     


Asp Ser Ile Lys Ile Gly Asp Asp Lys Tyr Ser Asn Val Lys Gly Glu 
            180                 185                 190         


Asn Lys Arg Ser Arg Ile Tyr Glu Tyr Tyr Lys Lys Ser Glu Asn Leu 
        195                 200                 205             


Lys Lys Phe Glu Glu Asn Ile Arg Glu Ala Phe Glu Lys Leu Tyr Thr 
    210                 215                 220                 


Glu Glu Asn Ile Lys Glu Leu Tyr Ser Lys Ile Glu Glu Ile Leu Lys 
225                 230                 235                 240 


Lys Thr His Leu Lys Ser Ile Val Arg Glu Phe Tyr Gln Asn Glu Ile 
                245                 250                 255     


Ile Gly Glu Ser Glu Phe Ser Lys Lys Asn Gly Asp Gly Ile Ser Ile 
            260                 265                 270         


Leu Tyr Asn Gln Ile Lys Asp Ser Ile Lys Lys Glu Glu Asn Phe Ile 
        275                 280                 285             


Glu Phe Ile Glu Asn Thr Gly Asn Leu Glu Leu Lys Glu Leu Thr Lys 
    290                 295                 300                 


Ser Gln Ile Phe Tyr Lys Tyr Phe Leu Glu Asn Glu Glu Leu Asn Asp 
305                 310                 315                 320 


Glu Asn Ile Lys Phe Ala Phe Cys Tyr Phe Val Glu Ile Glu Val Asn 
                325                 330                 335     


Asn Leu Leu Lys Glu Asn Val Tyr Lys Ile Lys Arg Phe Asn Glu Ser 
            340                 345                 350         


Asn Lys Lys Arg Ile Glu Asn Ile Phe Glu Tyr Gly Lys Leu Lys Lys 
        355                 360                 365             


Leu Ile Val Tyr Lys Leu Glu Asn Lys Leu Asn Asn Tyr Val Arg Asn 
    370                 375                 380                 


Cys Gly Lys Tyr Asn Tyr His Met Glu Asn Gly Asp Ile Ala Thr Ser 
385                 390                 395                 400 


Asp Ile Asn Met Arg Asn Arg Gln Thr Glu Ala Phe Leu Arg Ser Ile 
                405                 410                 415     


Ile Gly Val Ser Ser Phe Gly Tyr Phe Ser Leu Arg Asn Ile Leu Gly 
            420                 425                 430         


Val Asn Asp Asp Asp Phe Tyr Glu Thr Glu Glu Asp Leu Thr Lys Lys 
        435                 440                 445             


Glu Arg Arg Asn Leu Glu Lys Ala Lys Glu Asp Ile Thr Ile Lys Asn 
    450                 455                 460                 


Thr Phe Asp Glu Val Val Val Lys Ser Phe Gln Lys Lys Gly Ile Tyr 
465                 470                 475                 480 


Asn Ile Lys Glu Asn Leu Lys Met Phe Tyr Gly Asp Ser Phe Asp Asn 
                485                 490                 495     


Ala Asp Lys Asp Glu Leu Lys Gln Phe Phe Val Asn Met Leu Asn Ala 
            500                 505                 510         


Ile Thr Ser Ile Arg His Arg Val Val His Tyr Asn Met Asn Thr Asn 
        515                 520                 525             


Ser Glu Asn Ile Phe Asn Phe Ser Gly Ile Glu Val Ser Lys Leu Leu 
    530                 535                 540                 


Lys Ser Ile Phe Glu Lys Glu Thr Asp Lys Arg Glu Leu Lys Leu Lys 
545                 550                 555                 560 


Ile Phe Arg Gln Leu Asn Ser Ala Gly Val Phe Asp Tyr Trp Glu Asn 
                565                 570                 575     


Arg Lys Ile Asp Lys Tyr Leu Glu Asn Ile Glu Phe Lys Phe Val Asn 
            580                 585                 590         


Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys Leu Tyr Asn Arg Ile 
        595                 600                 605             


Asp Asn Leu Lys Gly Asn Asn Ala Leu Asn Leu Gly Tyr Ile Asn Ile 
    610                 615                 620                 


Pro Lys Arg Lys Glu Ala Arg Asp Ser Gln Ile Tyr Leu Leu Lys Asn 
625                 630                 635                 640 


Ile Tyr Tyr Gly Glu Phe Val Glu Lys Phe Val Asn Asn Asn Asp Asn 
                645                 650                 655     


Phe Glu Lys Ile Phe Arg Glu Ile Ile Glu Ile Asn Lys Lys Asp Gly 
            660                 665                 670         


Thr Asn Thr Lys Thr Lys Phe Tyr Lys Leu Glu Lys Phe Glu Thr Leu 
        675                 680                 685             


Lys Ala Asn Ala Pro Ile Glu Tyr Leu Glu Lys Leu Gln Ser Leu His 
    690                 695                 700                 


Gln Ile Asn Tyr Asn Arg Glu Lys Val Glu Glu Asp Lys Asp Ile Tyr 
705                 710                 715                 720 


Val Asp Phe Val Gln Lys Ile Phe Leu Lys Gly Phe Ile Asn Tyr Leu 
                725                 730                 735     


Gln Gly Ser Asp Leu Leu Lys Ser Leu Asn Leu Leu Asn Leu Lys Lys 
            740                 745                 750         


Asp Glu Ala Ile Ala Asn Lys Lys Ser Phe Tyr Asp Glu Lys Leu Lys 
        755                 760                 765             


Leu Trp Gln Asn Asn Gly Ser Asn Leu Ser Lys Met Pro Glu Glu Ile 
    770                 775                 780                 


Tyr Asp Tyr Ile Lys Lys Ile Lys Ile Asn Lys Ile Asn Tyr Ser Asp 
785                 790                 795                 800 


Arg Met Ser Ile Phe Tyr Leu Leu Leu Lys Leu Ile Asp His Lys Glu 
                805                 810                 815     


Leu Thr Asn Leu Arg Gly Asn Leu Glu Lys Tyr Val Ser Met Asn Lys 
            820                 825                 830         


Asn Lys Ile Tyr Ser Glu Glu Leu Asn Ile Val Asn Leu Val Ser Leu 
        835                 840                 845             


Asp Asn Asn Lys Val Arg Ala Asn Phe Asn Leu Lys Pro Glu Asp Ile 
    850                 855                 860                 


Gly Lys Phe Leu Lys Thr Glu Thr Ser Ile Arg Asn Ile Asn Gln Leu 
865                 870                 875                 880 


Asn Asn Phe Ser Glu Ile Phe Ala Asp Gly Glu Asn Val Ile Lys His 
                885                 890                 895     


Arg Ser Phe Tyr Asn Ile Lys Lys Tyr Gly Ile Leu Asp Leu Leu Glu 
            900                 905                 910         


Lys Ile Val Asp Lys Ala Asp Leu Lys Ile Thr Lys Glu Glu Ile Lys 
        915                 920                 925             


Lys Tyr Glu Asn Leu Gln Asn Glu Leu Lys Arg Asn Asp Phe Tyr Lys 
    930                 935                 940                 


Ile Gln Glu Arg Ile His Arg Asn Tyr Asn Gln Lys Pro Phe Leu Ile 
945                 950                 955                 960 


Lys Asn Asn Glu Lys Asp Phe Asn Asp Tyr Lys Lys Ala Ile Glu Asn 
                965                 970                 975     


Ile Gln Asn Tyr Thr Gln Leu Lys Asn Lys Ile Glu Phe Asn Asp Leu 
            980                 985                 990         


Asn Leu Leu Gln Ser Leu Leu Phe  Arg Ile Leu His Arg  Leu Ala Gly 
        995                 1000                 1005             


Tyr Thr  Ser Leu Trp Glu Arg  Asp Leu Gln Phe Lys  Leu Lys Gly 
    1010                 1015                 1020             


Glu Tyr  Pro Glu Asn Lys Tyr  Ile Asp Glu Ile Phe  Asn Phe Asp 
    1025                 1030                 1035             


Asn Ser  Lys Asn Lys Ile Tyr  Asn Glu Lys Asn Glu  Arg Gly Gly 
    1040                 1045                 1050             


Ser Val  Val Ser Lys Tyr Gly  Tyr Phe Leu Val Glu  Lys Asp Gly 
    1055                 1060                 1065             


Glu Ile  Gln Arg Lys Asn Ala  Arg Asp Lys Lys Lys  Asn Lys Ile 
    1070                 1075                 1080             


Ile Lys  Lys Glu Gly Leu Glu  Ile Arg Asn Tyr Ile  Ala His Phe 
    1085                 1090                 1095             


Asn Tyr  Ile Pro Asp Ala Thr  Lys Ser Ile Leu Glu  Ile Leu Glu 
    1100                 1105                 1110             


Glu Leu  Arg Asn Leu Leu Lys  Tyr Asp Arg Lys Leu  Lys Asn Ala 
    1115                 1120                 1125             


Val Met  Lys Ser Ile Lys Asp  Ile Phe Lys Glu Tyr  Gly Leu Ile 
    1130                 1135                 1140             


Ile Glu  Phe Lys Ile Ser His  Val Asn Asn Ser Glu  Lys Ile Glu 
    1145                 1150                 1155             


Val Leu  Asn Val Asp Ser Glu  Lys Ile Lys His Leu  Lys Asn Asn 
    1160                 1165                 1170             


Gly Leu  Val Thr Thr Arg Asn  Ser Glu Asp Leu Cys  Glu Leu Ile 
    1175                 1180                 1185             


Lys Met  Met Leu Glu Tyr Lys  Lys Ser 
    1190                 1195         


<210>  71
<211>  1403
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  71

Met Lys Ile Val Arg Gly Tyr Gly Arg Ser Val Val Gly Lys Phe Ala 
1               5                   10                  15      


Glu Glu Asp Gly Ala Asp Ile Lys Asp Leu Lys Ile Arg Lys Leu His 
            20                  25                  30          


Lys Thr Gly Gly Asp Glu Asp Leu Ser Phe Ala Ala Phe Ala Arg Thr 
        35                  40                  45              


Glu Gly Glu Phe Ile Leu Ala Leu Trp Val Ser Val Ile Asp Lys Ile 
    50                  55                  60                  


Val Ala Lys Ala Thr Lys Asn Ala Glu Lys Gly Asn Glu Lys Ala Lys 
65                  70                  75                  80  


Asn Ala Ile Ala Lys Lys Leu Arg Gln Lys Ile Gly Ala Ala Ala Trp 
                85                  90                  95      


Gln Lys Leu Leu Arg Ala Asn Arg Leu Glu Leu Ala Ala Ile Trp Asn 
            100                 105                 110         


Trp Lys Ile Gly Ala Glu Ser Ser Ser Arg Gln Ser Glu Asn Phe Pro 
        115                 120                 125             


Gln Gly Asn Trp Tyr Pro Ala Phe Leu Gly Asn Ala Ala Pro Glu Gly 
    130                 135                 140                 


Leu Ser Asp Pro Gln Ile Thr Glu Leu Val His Asp Ile Asp Thr His 
145                 150                 155                 160 


Ile His Lys Ala Met Arg Gln Ile Gly Gly Val Glu Gly Lys Asp Lys 
                165                 170                 175     


Asn Arg Leu Arg Ser Glu Gly Leu Leu Ala Asp Ile Val Ala Ala Val 
            180                 185                 190         


Glu Lys Asn Thr Leu Lys Ser Ala His Glu Lys Gln Phe Pro Gln Gly 
        195                 200                 205             


Lys Lys Arg Asp Cys Ala Phe Ser Lys Glu Asp Trp Gln Val Tyr Arg 
    210                 215                 220                 


Asp Ala Ala Asn Lys Ala Val Gly Gly Asp Phe Val Ala Asp Leu Lys 
225                 230                 235                 240 


Gly Ala Val Leu Asn Thr Ala Asp Lys Asp Lys Pro Tyr His Lys Ala 
                245                 250                 255     


Ile Glu Tyr Leu Lys Lys Val Val Trp Pro Gln Ile Phe Cys Asp Glu 
            260                 265                 270         


Asn Gly Ala Val Leu Gly Arg Lys Gln Ala Thr Glu Gln Met Pro Lys 
        275                 280                 285             


Leu Leu Val Val His Asp Ala Ile Thr Ala Tyr Tyr Lys Lys Leu Leu 
    290                 295                 300                 


Lys Asp Arg Gly Ser Ile Ala Gly Tyr Lys Val Lys Glu Lys Gly Glu 
305                 310                 315                 320 


Asn Tyr Glu Lys Ala Thr Gly Ile Lys Arg Gln Gly Glu Lys Ala Pro 
                325                 330                 335     


Ala Lys Leu Glu Leu Leu Leu Pro Ala Ser Val Asn Lys Leu Lys Trp 
            340                 345                 350         


Ile Leu Cys Lys Gln His Glu Asn Arg Asp Val Asn His Tyr Ile Arg 
        355                 360                 365             


Leu Gly Lys Val Leu His Tyr Thr Ala Ser Gln Phe Ser Asn Glu Asn 
    370                 375                 380                 


Gln Asp Ser Ala Ala Tyr Ile Ile Gly Asn Trp Asp Lys Ala Val Glu 
385                 390                 395                 400 


Ala Leu Pro Thr Ser Pro Tyr Trp Thr Ser Glu Gly Gln Thr Gln Ile 
                405                 410                 415     


Lys Gln Asn Glu Ala Phe Ile Arg Val Trp Arg Arg Val Leu Ala Phe 
            420                 425                 430         


Ala Val His Ser Leu Lys Asn Trp Ala Asp Pro Asp Asn Lys Val Ala 
        435                 440                 445             


Gly Asp Pro Thr Ile Lys Pro Thr Trp Gly Glu Ile Gln Lys Asn Phe 
    450                 455                 460                 


Ala Asp Ser Ser Phe Ala Gln Lys Phe Ala Gln Lys Tyr Glu Leu Phe 
465                 470                 475                 480 


Phe Gly Lys Ile Trp Gln Gly Ser Lys Gln Leu Glu Leu Leu Asp Tyr 
                485                 490                 495     


Leu Gln Glu Arg Leu Met Glu Leu Arg Gly Ser Val Phe His Phe Lys 
            500                 505                 510         


Gly Leu Arg Lys Phe Thr Ser Glu Leu Lys Ala Lys Asn Pro Pro Gln 
        515                 520                 525             


Leu Met Arg Asp Phe Tyr Glu Asp Asp Cys Gln Ala Tyr Arg Ala Lys 
    530                 535                 540                 


Pro Leu Lys Ile Met Gln Gly Ala Lys Phe Glu Arg Phe Phe Ser Lys 
545                 550                 555                 560 


Glu Gln Ile Glu Glu Met Leu Glu Ala Ala Gln Ala Trp Asp Ala Val 
                565                 570                 575     


Ser Val Thr Ala Pro Lys Gly Asp Asp Gly Gln Gln Leu Pro Leu Pro 
            580                 585                 590         


Thr Leu Lys Arg Leu Leu Val Arg Val Lys Asn Thr Trp Ser Glu Asp 
        595                 600                 605             


Gly Glu Gly Asn Ile Ala Leu Pro Pro Tyr Asp Ser Ala Ala Lys Lys 
    610                 615                 620                 


Asn Glu Lys Ala Asp Lys Ala Ala Glu Asn Glu Val Ser Val Glu Thr 
625                 630                 635                 640 


Lys Ala Ala Glu Thr Asp Asp Glu Lys Arg Glu Lys Ala Arg His Ala 
                645                 650                 655     


Gln Tyr Ile Ala Ile Lys Gln Leu Tyr Glu Leu Pro Phe Arg Ala Trp 
            660                 665                 670         


Leu Ala Lys Leu Ser Pro Glu Lys Val Asn Asp Tyr Ile Asp Arg Ala 
        675                 680                 685             


Val Lys Arg Ala Lys Ala Ala Ala Gln Glu Asn Glu Pro Asp Glu Glu 
    690                 695                 700                 


Val Lys Lys Cys Ile Val Ala Arg Ala Ala Ser Leu Pro Arg Leu Lys 
705                 710                 715                 720 


Ala Lys Glu Arg Ile Asp Gly Phe Phe Tyr Asn Leu Met Ala Glu Thr 
                725                 730                 735     


Ala Ser Glu Met Arg Val Gln Lys Asp Tyr Ser Ser Asp Gly Glu Gln 
            740                 745                 750         


Ala Lys Lys Gln Ala Lys Tyr Ile Glu Asn Leu Lys Cys Asp Val Ile 
        755                 760                 765             


Ala Tyr Ala Leu Ala Asp Tyr Leu Gln Ala Lys His Glu Val Glu Glu 
    770                 775                 780                 


Lys Gly Lys Gln Thr Lys Leu Val Cys Phe Lys Tyr Val Leu Gly Glu 
785                 790                 795                 800 


Gly Glu Ala Lys Gly Ser Ala Glu Lys Ala Tyr Leu Leu Pro Ala Arg 
                805                 810                 815     


Pro Asp Ala Pro Gln Asp Lys Glu Lys Val Lys Val Phe Trp Ala Gly 
            820                 825                 830         


Ile Thr Thr Gly Gln Ile Thr Thr Asp Lys Asn Glu Ala Trp Asn Lys 
        835                 840                 845             


Leu Thr Glu Glu Gly Lys Phe Leu Pro Trp Leu Tyr Phe Leu Leu His 
    850                 855                 860                 


Leu Ala Pro Val Glu Glu Val Ala Gly Leu Arg Gln Gln Ile Arg Lys 
865                 870                 875                 880 


Trp Gln Ile Val Val Thr Lys Leu Glu Ile Asp Lys Thr Gly Asp Glu 
                885                 890                 895     


Asp Ser Gly Lys Lys Gln Ala Gly Lys Lys Ala Glu Ala Ala Lys Val 
            900                 905                 910         


Arg Ser Leu Leu Cys Ala Leu Asn Leu Tyr Ile Glu Leu His Asp Glu 
        915                 920                 925             


Gln Phe Asn Gln Gly Gly Gln Asn Lys Arg Glu Phe Ser Pro Glu Asp 
    930                 935                 940                 


Arg Glu Lys Leu Arg Asp Tyr Tyr Ile Gly Glu Gln Asp Tyr Lys Ser 
945                 950                 955                 960 


Val Val Asn Arg Gln Lys Asp Asn Ala Asp Asn Glu Gln Met Ile Arg 
                965                 970                 975     


Gly Leu Arg Glu Met Arg Arg Phe Gly Gly Asp Thr Ala Leu Asp Lys 
            980                 985                 990         


Ile Leu Glu Glu Lys Glu His Gln  Ile Ser Pro Asp His  Ile Lys Ala 
        995                 1000                 1005             


Trp Lys  Glu Asn Ser Asp Lys  Ile Ala Ala Ala Gln  Asn Thr Arg 
    1010                 1015                 1020             


Lys Glu  Arg His Lys Glu Trp  Ala Lys Leu Glu Asn  Lys Val Asn 
    1025                 1030                 1035             


Lys Glu  Trp Trp Asp Ser Lys  Lys Lys Gly Lys Asn  Thr Asn Tyr 
    1040                 1045                 1050             


Lys Leu  Gly Asp Lys Gly Gln  Val Tyr Ala Ala Ala  Leu Glu Thr 
    1055                 1060                 1065             


Ile Ile  Lys His Ser Glu Ala  Val Ala Gln Ile Glu  Leu His Asn 
    1070                 1075                 1080             


Gln Leu  Asn Leu His Lys Leu  Leu Leu Ala Val Leu  Gly Arg Leu 
    1085                 1090                 1095             


Val Asp  Phe Ser Gly Leu Phe  Glu Arg Asp Leu Tyr  Phe Thr Met 
    1100                 1105                 1110             


Leu Ala  Leu Phe Tyr Glu Asn  Lys Val Glu Arg Leu  Glu Asp Lys 
    1115                 1120                 1125             


Phe Glu  Asp Ser Gly Ala Leu  Leu Lys Gln Gly Arg  Ile Pro Glu 
    1130                 1135                 1140             


Ala Phe  Ala Glu Gln Leu Lys  Glu Gly Lys Glu Lys  Glu Asp Leu 
    1145                 1150                 1155             


Lys Lys  Ile Phe Ser Asn Lys  Lys Leu Ala Gly Lys  Asp Val Leu 
    1160                 1165                 1170             


Met Trp  Ile Arg Asn Arg Phe  Ala His Leu Ala Val  Leu Glu Ser 
    1175                 1180                 1185             


Lys Asp  Ile Asp Val Thr Arg  Glu Leu Asn Phe Ala  Arg Ala Leu 
    1190                 1195                 1200             


Met Ser  Tyr Asp Arg Lys Leu  Lys Asn Ala Val Thr  Lys Ser Val 
    1205                 1210                 1215             


Ala Glu  Met Leu Ala Arg His  Lys Leu Glu Ile Leu  Trp Gln Met 
    1220                 1225                 1230             


Gly Lys  Glu Gln His Ser Ala  Gly Ser Gly Asp Ser  Lys Asp Ser 
    1235                 1240                 1245             


Val Ala  Ile Ala Asp Lys Lys  Ile Lys Val Lys Ser  Gly His Tyr 
    1250                 1255                 1260             


Leu His  Gly Ala Lys Val Glu  Pro Arg Ile Ile His  His Leu Gly 
    1265                 1270                 1275             


Asp Asn  Lys Ala Glu Asp Leu  Gln Glu Ser Leu Gln  Asn Lys Glu 
    1280                 1285                 1290             


Phe Thr  Ser Met Val Gln Met  Leu Phe Gly Gly Gly  Asn Lys Leu 
    1295                 1300                 1305             


Lys Ala  Asp Lys Glu Ala Lys  Glu Lys Ala Glu Ala  Glu Lys Lys 
    1310                 1315                 1320             


Lys Arg  Thr Glu Glu Ala Gln  Lys Lys Gly Lys Gln  Ser Gly Val 
    1325                 1330                 1335             


Val Lys  Phe Phe Asn Ala Asp  Lys Gly Phe Gly Phe  Ile Lys Pro 
    1340                 1345                 1350             


Asp Asn  Gly Ser Ala Asp Ile  Phe Val His Val Ser  Ala Val Gln 
    1355                 1360                 1365             


Ala Ser  Gly Leu Met Ser Leu  Gln Glu Gly Gln Lys  Val Ser Tyr 
    1370                 1375                 1380             


Glu Thr  Glu Ala Asp Lys Arg  Gly Lys Gly Pro Lys  Ala Val Lys 
    1385                 1390                 1395             


Leu Ser  Ile Ile Glu 
    1400             


<210>  72
<211>  1163
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  72

Met Leu Val Ile Lys Pro Tyr Gly Arg Ser Asn Val Lys Lys Ala Ala 
1               5                   10                  15      


Ala Gly Glu Lys Ala Glu Asn Cys Trp Arg Ala Ile Arg Thr Val Glu 
            20                  25                  30          


Lys Asn Ser Gly Gln Ser Lys Ile Val Glu Arg Pro Ile Ala Gly Phe 
        35                  40                  45              


Ile Ala Glu Arg Asp Glu Ala Val Ile Ala Gln Trp Val Ser Ile Ile 
    50                  55                  60                  


Asp Lys Ile Ile Ala Lys Pro Gly Glu Lys Asp Ser Asn Asn Lys Ala 
65                  70                  75                  80  


Gln Glu Leu Arg Lys Ile Leu Ala Ala Ala Ala Trp Ala Val Ile Lys 
                85                  90                  95      


Ser Lys Asn Leu Leu Ala Lys Leu Ala Gly Thr Pro Ala Glu Arg Gln 
            100                 105                 110         


Glu Ile Glu Lys Ile Trp Gln Trp Lys Met Ala Ala Thr Gln Pro Lys 
        115                 120                 125             


Glu Pro Arg Ala Leu Glu Gly Arg Trp Tyr Glu Ala Phe Ala Ala Gly 
    130                 135                 140                 


Ile Pro Cys Asp Thr Gln His Ile Lys Ala Asp Ala Ala Lys Ile Ala 
145                 150                 155                 160 


Asp Arg Ile Tyr Ile His Leu Tyr Arg Gln Ala Tyr Arg Phe Pro Leu 
                165                 170                 175     


Lys Ser Lys Thr Ala Gln Gly Ser Ala Ala Gly Asp Ser Arg Cys His 
            180                 185                 190         


Gln Lys Gly Leu Ile Gln His Arg Ala Ser Ala Ile Ala Glu Asn Ile 
        195                 200                 205             


Leu His Ile Pro Ala Phe Leu Met Cys Ala Ala Asp Lys Glu Asp Tyr 
    210                 215                 220                 


Ser Asp Ser Asp Lys Glu Ala Tyr Ser Glu Asp Asp Lys Lys Asp Tyr 
225                 230                 235                 240 


Ser Ala Ala Ala Gly Asn Phe Ala Ala Glu Ile Lys Arg Ala Ile Leu 
                245                 250                 255     


Val Ser Glu Lys Leu Ser Arg Thr Asp Tyr Lys Asp Arg Pro Tyr Glu 
            260                 265                 270         


Ile Ala Ala Arg Ile Met Arg Glu Thr Gly Asp Arg Leu Phe Ala Cys 
        275                 280                 285             


Leu Gly Asp Lys Ala Gln Lys Pro Gly Leu Leu Ala Leu His Ser Gln 
    290                 295                 300                 


Ile Lys Ser Gly Tyr Lys Ala Leu Leu Lys Gly Arg Lys Gln Leu Lys 
305                 310                 315                 320 


Ala Arg Leu Glu Tyr Leu Leu Pro Gln Asp Asn Ala Ala Leu Phe Gln 
                325                 330                 335     


Leu Val Glu Ala Gln Gln Gln Asn Arg Tyr Ile Asn His Leu Ile Arg 
            340                 345                 350         


Leu Gly Lys Ile Val His Tyr Thr Ala Ile Val Pro Asp Thr Ala Ser 
        355                 360                 365             


Leu Ala Ala Leu Gln Ser Ser Pro Lys Thr Ile Ile Asn Asn Trp Pro 
    370                 375                 380                 


Gln Lys Glu Ala Val Glu Gly Ser Arg Phe Trp Ser Ser Ala Gly Gln 
385                 390                 395                 400 


Thr Glu Ile Lys Gln Asn Glu Ala Phe Val Arg Val Trp Arg Gly Ala 
                405                 410                 415     


Leu Ala Phe Ala Ala Arg Thr Val Lys Asp Trp Val Asp Pro Gln Asp 
            420                 425                 430         


Lys Ile Pro Gly Asp Ile Leu Leu Asn Gln Thr Thr Ala Leu Asp Asn 
        435                 440                 445             


Phe Asp Ala Asp Tyr Phe Glu Gln Lys Tyr Gln Ile Leu Phe Gly Asn 
    450                 455                 460                 


Lys Trp Glu Ala Glu Glu Asp Lys Lys Ala Leu Leu Glu Phe Ser Leu 
465                 470                 475                 480 


Ser Asn Leu Tyr Ala Leu Arg Asn Ala Ala Phe His Phe Ser Asn Leu 
                485                 490                 495     


Arg Leu Phe Val Glu Ala Leu Met Pro Lys Lys Ala Leu Glu Ala Glu 
            500                 505                 510         


Lys Leu Asp Lys Phe Leu Ala Thr Phe Tyr Thr Asp Ala Cys His Asn 
        515                 520                 525             


Tyr Gln Leu Lys Gln Lys Ala Ile Met Gln Gly Ala Gln Phe His Asp 
    530                 535                 540                 


Phe Phe Ser Glu Ala Glu Ile Glu Thr Ile Trp Gln Ala Leu Thr Ser 
545                 550                 555                 560 


Ala Gln Ala Ser Pro Leu Pro Val Pro Arg Leu Lys Arg Val Leu Glu 
                565                 570                 575     


Arg Ala Ala Asp Ala Trp Lys Gly Trp Asp Asn Arg Leu Gln Val Pro 
            580                 585                 590         


Pro Tyr Ser Thr Ala Glu Glu Arg Glu Ala Ser Ala Trp Ala Arg Cys 
        595                 600                 605             


Gln Tyr Thr Ala Ala Lys Leu Leu Tyr Asp Gly Pro Phe Lys Asn Trp 
    610                 615                 620                 


Leu Glu Gly Leu Gly Gln Ala Ala Leu Ser Gly Tyr Ile Asn Arg Ala 
625                 630                 635                 640 


Leu Glu His Thr Ser Gln Ala Ala Lys Lys Ile Lys Asn Gly Asp Lys 
                645                 650                 655     


Glu Phe Glu Glu Phe Ile Ile Ser Lys Ala Gly Lys Ile Ala Glu Leu 
            660                 665                 670         


Gly Asp Glu Asn Asp Phe Arg Asp Phe Phe Ser Thr Leu Thr Ala Ala 
        675                 680                 685             


Thr Ala Thr Glu Met Arg Val Gln Asn Phe Tyr Gln Ser Asp Gly Lys 
    690                 695                 700                 


Ala Ala Lys Lys Gln Ala Asp Tyr Ile Glu Lys Phe Lys Cys Asp Ile 
705                 710                 715                 720 


Val Ala Leu Ala Phe Ala Asp Tyr Val Arg Lys Val Ile Gly Leu Arg 
                725                 730                 735     


Asn Ile Ala Ala Phe Cys Asn Lys Glu Arg Thr Glu Lys Pro Gly Ser 
            740                 745                 750         


Ser Arg Ile Tyr Asp Arg Leu Pro Val Ser Val Lys Gln Asn Ser Thr 
        755                 760                 765             


Gly Ala Pro Trp Gln Ser Arg Leu Tyr Phe Leu Leu His Leu Met Pro 
    770                 775                 780                 


Val Glu Glu Ala Gly Ser Leu Arg Gln Gln Leu Lys Lys Trp Glu Ile 
785                 790                 795                 800 


Ile Thr Asp Lys Ser His Gly Lys Gly Ser Arg Gly Gly Thr Val Leu 
                805                 810                 815     


Thr Gln Leu Leu Ala Val Phe Asp Leu Tyr Ile Ala Met His Asp Ala 
            820                 825                 830         


Gln Phe Val Gly Ala Glu Leu Ala Ser Leu Glu Ser Asp Lys Glu Thr 
        835                 840                 845             


Ala Gln Ala Leu Phe Glu Asn Glu Gly Asp Phe Arg Gln Ile Phe Pro 
    850                 855                 860                 


Glu Lys Lys Asp Gly Ile Glu Asp Glu His Leu Pro Ile Arg Gly Leu 
865                 870                 875                 880 


Arg Glu Met Gln Arg Phe Gly Thr Ser Leu Leu His Asn Phe Tyr Glu 
                885                 890                 895     


Lys His Gln Ile Ser Glu Ala Ser Val Ala Arg Trp Gln Lys Leu Glu 
            900                 905                 910         


Lys Ile Ile Ala Gln Glu Gln Arg Lys Leu Lys Lys Leu His Gln Asp 
        915                 920                 925             


Trp Val Asn Ser Lys Lys Arg Lys Asn Asn Ile Lys Trp Lys Glu Glu 
    930                 935                 940                 


Asn Ala Tyr Glu Ala Ala Leu Lys Leu Val Thr Glu His Arg His Leu 
945                 950                 955                 960 


Thr Ala Arg Val Met Leu Gln Ser His Val Arg Leu His Arg Leu Leu 
                965                 970                 975     


Ile Lys Ile Leu Gly Arg Leu Val Asp Phe Ala Gly Leu Trp Glu Arg 
            980                 985                 990         


Asp Leu Tyr Phe Val Leu Leu Ala  Gln Leu Tyr Cys Lys  Gly Val Glu 
        995                 1000                 1005             


Asp Ile  Glu Glu Gln Phe Lys  Asp Lys Gly Ala Lys  Leu Gly Thr 
    1010                 1015                 1020             


Gly Gln  Ile Val Ala Ala Leu  Arg Lys Leu Lys Asp  Thr Gly Leu 
    1025                 1030                 1035             


Gln Ala  Lys Ile Ala Ser Leu  Leu Asn Gln Gln Glu  Thr Gln Glu 
    1040                 1045                 1050             


Ile Arg  Asn Gly Phe Asp His  Phe Asp Thr Leu Lys  Lys Lys Tyr 
    1055                 1060                 1065             


Phe Pro  Val Asn Leu Thr Ala  Glu Val Asn Lys Ala  Arg Arg Leu 
    1070                 1075                 1080             


Met Ala  Tyr Asp Arg Lys Leu  Lys Asn Ala Val Thr  Lys Ser Val 
    1085                 1090                 1095             


Ile Asp  Leu Leu Arg Arg Glu  Asn Ile Glu Leu Lys  Trp Ser Met 
    1100                 1105                 1110             


Gly Ala  Asp His Glu Leu Glu  Gly Val Leu Ser Ile  Phe Ser Ala 
    1115                 1120                 1125             


Lys Ala  Cys His Leu Ala Lys  Glu Tyr Gly Asn Asn  Lys Ile Ala 
    1130                 1135                 1140             


Glu Glu  Leu Cys Asp Ala His  Tyr Val Ala Met Ile  Glu Ser Leu 
    1145                 1150                 1155             


Leu Asn  Gly Asn Ser 
    1160             


<210>  73
<211>  1101
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  73

Met Arg Ile Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Ile Tyr Ser Glu 
            20                  25                  30          


Gln Ala Val Ser Asn Glu Thr Asn Asn Ile Leu Pro Val Lys Lys Met 
        35                  40                  45              


Asp Ser Phe Asn Leu Ser Ile Leu Asn Lys Thr Ile Ile Lys Phe Glu 
    50                  55                  60                  


Thr Val Lys Lys Gln Lys Leu Asn Leu Asp Gln Tyr Lys Ile Val Glu 
65                  70                  75                  80  


Lys Ile Phe Lys Tyr Pro Lys Gln Glu Leu Pro Lys Gln Ile Asn Ala 
                85                  90                  95      


Glu Glu Ile Leu Gln Phe Leu Asn His Lys Phe Gln Glu Pro Val Lys 
            100                 105                 110         


Tyr Trp Lys Asn Gly Lys Glu Glu Ser Phe Asn Leu Thr Leu Leu Ile 
        115                 120                 125             


Val Glu Ala Val Lys Thr Gln Glu Lys Arg Lys Leu Gln Pro Tyr Tyr 
    130                 135                 140                 


Asp Trp Lys Thr Trp Tyr Ile Gln Thr Lys Ser Asp Leu Leu Lys Lys 
145                 150                 155                 160 


Ser Ile Glu Asn Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg 
                165                 170                 175     


Lys Lys Ala Leu Leu Ala Trp Glu Thr Glu Phe Thr Thr Ser Gly Ser 
            180                 185                 190         


Ile Asp Leu Thr His Phe His Lys Val Tyr Met Thr Asp Val Leu Cys 
        195                 200                 205             


Thr Ala Leu Gln Lys Val Glu Pro Ser Ala Asp Glu Arg Gly Lys Met 
    210                 215                 220                 


Asn Ser Asn Ala Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Asn His 
225                 230                 235                 240 


Gln Pro Ala Ile Phe Gly Thr Arg Glu Ala Pro Asn Glu Val Asn Arg 
                245                 250                 255     


Ala Asp Asn Gln Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu 
            260                 265                 270         


Glu His Tyr Phe Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Ala Asp 
        275                 280                 285             


Asp Ile Ser His Tyr Leu Lys Ala Gln Thr Leu Lys Thr Thr Ile Glu 
    290                 295                 300                 


Lys Gln Leu Val Asn Ala Ile Arg Ala Asn Ile Ile Gln Gln Gly Lys 
305                 310                 315                 320 


Thr Asn His His Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile 
                325                 330                 335     


Arg Ile Lys Thr Asn Glu Ala Phe Val Leu Asn Leu Ile Gly Thr Cys 
            340                 345                 350         


Ala Phe Ala Ala Asn Asn Ile Arg Asn Met Val Asp Lys Glu Gln Ile 
        355                 360                 365             


Ser Asp Ile Leu Gly Lys Arg Glu Phe Ile Asp Ser Leu Thr Lys Ser 
    370                 375                 380                 


Arg Ile Ser Ser Gln Leu Tyr Ser Phe Phe Phe Gly Glu Asn Leu Ser 
385                 390                 395                 400 


Thr Asn Lys Ala Glu Lys Glu Thr Gln Leu Trp Gly Ile Arg Gly Ala 
                405                 410                 415     


Val Gln Gln Ile Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu 
            420                 425                 430         


Thr Thr Ile Phe Asn Ile Cys Lys Phe Glu Asn Pro Thr Asp Ala Asp 
        435                 440                 445             


Pro Lys Gln Gln Thr Asn Tyr Val Asp Ser Ile Tyr Lys Thr Leu Phe 
    450                 455                 460                 


Ile Lys Glu Leu Glu Lys Ile Pro Glu Ala Phe Ala Gln Gln Leu Lys 
465                 470                 475                 480 


Thr Gly Gly Ala Leu Ser Tyr Tyr Thr Val Glu Asn Leu Lys Thr Leu 
                485                 490                 495     


Leu Thr Thr Phe Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala 
            500                 505                 510         


Pro Gly Phe Lys Lys Val Leu Asn Gly Gly Ile Asn Tyr Gln Asn Ala 
        515                 520                 525             


Lys Gln Asp Glu Ser Phe Tyr Glu Leu Met Leu Glu Arg Tyr Leu Arg 
    530                 535                 540                 


Lys Glu Asn Phe Ala Glu Glu Ala Tyr Asn Ala Arg Tyr Phe Leu Leu 
545                 550                 555                 560 


Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Lys Phe Thr Ala Asp Arg 
                565                 570                 575     


Lys Ala Phe Ala Asp Ser Val Gly Phe Val Gln Leu Gln Asn Arg Lys 
            580                 585                 590         


Gln Ala Glu Asn Ser Lys Arg Pro Lys Ala Phe Ala Phe Glu Ala Val 
        595                 600                 605             


Arg Pro Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala Tyr Val 
    610                 615                 620                 


Gln Ser Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys Ala Thr 
625                 630                 635                 640 


Asp Glu Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val Phe Ile 
                645                 650                 655     


Lys Gly Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe Val Gln 
            660                 665                 670         


Val Pro Gln Pro Gln Leu Thr Thr Thr Asp Ser Asn Gln Gln Lys Ala 
        675                 680                 685             


Asp Lys Leu Asn Gln Leu Glu Ala Ser Ile Thr Ala Asp Cys Lys Leu 
    690                 695                 700                 


Thr Ala Gln Tyr Ala Lys Thr Asp Asp Ala Thr His Ile Ala Phe Tyr 
705                 710                 715                 720 


Val Phe Cys Lys Leu Leu Asp Ala Gly His Leu Ser Asn Leu Arg Asn 
                725                 730                 735     


Glu Leu Ile Lys Phe Arg Gly Ser Val Lys Asp Phe Asp Phe His His 
            740                 745                 750         


Leu Leu Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val Val Pro 
        755                 760                 765             


Thr Asp Tyr Arg Asp Leu Tyr Ser Ser Gly Ala Asp Cys Leu Ala Arg 
    770                 775                 780                 


Leu Arg Pro Phe Ile Glu Gln Gly Ala Asp Ile Lys Asn Trp Ser Asp 
785                 790                 795                 800 


Leu Tyr Val Gln Thr Asp Lys Gln Thr Pro Val Ile His Ala Gly Ile 
                805                 810                 815     


Glu Leu Ser Val Lys Tyr Gly Thr Thr Ala Leu Leu Glu Gln Leu Ile 
            820                 825                 830         


Thr Cys Asn Pro Lys Phe Arg Val Met Glu Asp Asn Phe Thr Lys Trp 
        835                 840                 845             


Ser Ala Gln Lys Lys Glu Ile Glu Glu Lys Val Asn Lys His Thr Asn 
    850                 855                 860                 


Leu His Gln Gln Trp Val Glu Ala Lys Glu Lys Asp Asp Arg Glu Arg 
865                 870                 875                 880 


Val Lys Ser Lys Lys Asn Phe Val Arg Glu Tyr Val Lys Lys Asn Tyr 
                885                 890                 895     


Val Asp Tyr Ile Asn Asn Cys Ile Glu Ile Asn Asn Tyr Asn Trp Leu 
            900                 905                 910         


Asp Asn Lys Leu His Phe Val His Leu Asn His Leu His His Leu Thr 
        915                 920                 925             


Ile Asp Ile Leu Gly Arg Met Ala Gly Phe Val Ala Leu Trp Glu Arg 
    930                 935                 940                 


Asp Phe Gln Tyr Ile Thr Lys Tyr Thr Ala Ala Lys Glu Gly Thr Asp 
945                 950                 955                 960 


Ala Leu Ser Phe Asp Gly Gly Leu Pro Arg Leu Lys Asp Lys Gln Glu 
                965                 970                 975     


Tyr Tyr Asn Lys Leu Phe Leu Ser Asp Lys Tyr Thr Lys Val Arg Asn 
            980                 985                 990         


His Ile Ala His Phe Asn Tyr Leu  Thr Lys Asp Ala Ala  Asp Phe Ala 
        995                 1000                 1005             


Leu Leu  Asp Leu Ile Asn Glu  Leu Arg Glu Leu Leu  His Tyr Gly 
    1010                 1015                 1020             


Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ala Phe Ile  Asp Leu Phe 
    1025                 1030                 1035             


Glu Lys  His Gly Met Ile Leu  Lys Leu Lys Leu Asn  Thr Asp His 
    1040                 1045                 1050             


Gln Leu  Val Val Glu Ser Ile  Glu Pro Lys Lys Ile  Tyr His Leu 
    1055                 1060                 1065             


Gly Ser  Thr Ala Lys Asp Lys  Pro Glu Tyr Gln Tyr  Thr Thr Asn 
    1070                 1075                 1080             


Gln Val  Met Thr Val Tyr Cys  Asn Met Cys Arg Ser  Leu Leu Glu 
    1085                 1090                 1095             


Met Lys  Lys 
    1100     


<210>  74
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  74

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Thr Glu Asn Lys Asn Glu Glu Gln Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Leu Lys Lys Asn Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Ser Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Cys Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Thr Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Ile Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Gln Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Lys 
                405                 410                 415     


Arg Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Ile Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Ala Leu Glu Gly Glu Ser 
    450                 455                 460                 


Val Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Glu Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Ala Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Lys Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Lys Asp Asp Glu Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Ser Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Lys Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Ala Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Val Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Glu Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Lys Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  75
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  75

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Thr Glu Asn Lys Asn Glu Glu Gln Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Arg Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Leu Lys Lys Asn Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Lys Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Cys Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Ile Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Gln Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Ala Leu Glu Gly Glu Ser 
    450                 455                 460                 


Val Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Glu Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Ala Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Arg Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Lys Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Lys Gly Asp Lys Glu Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Glu Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Ser Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Lys Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Glu Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Val Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Thr Gln  
    1355                 1360 


<210>  76
<211>  1268
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  76

Met Lys Val Ser Lys Val Asn His Arg Arg Ala Ala Val Ala Val Asn 
1               5                   10                  15      


Lys Lys Ser Val Thr Val Asn Gly Ile Leu Tyr Asp Ala Pro Val Lys 
            20                  25                  30          


Lys Asn Val Lys Thr Gly Asn Met Ser Ala Tyr Val Ser Ser Lys Tyr 
        35                  40                  45              


Val Ile Asp Asn Val Val Lys Asn Ser Ser Arg Leu Tyr Ser Pro Phe 
    50                  55                  60                  


Ser Ser Lys Arg Ile Val Ile Asp Arg Glu Lys Ile Arg Ile Ala Asp 
65                  70                  75                  80  


Arg Leu Lys Gln Cys Tyr Val Asn Phe Val Lys Tyr Tyr Leu Ser Asn 
                85                  90                  95      


Gly Ser Leu Asn Glu Gln Gln Met Arg Phe Asn Pro Asn Asn Thr Tyr 
            100                 105                 110         


Met Ala Asp Ser Arg Val His Phe Cys Val Pro Ser Gly Ile Asp Ile 
        115                 120                 125             


Glu Ser Leu Ile Asn Ser Ile Val Asp Ser Ser Leu Arg Lys Ser Leu 
    130                 135                 140                 


Lys Arg Thr Tyr Arg Phe Glu Thr Asn Tyr Gly Glu Lys Asn Thr Phe 
145                 150                 155                 160 


Asn Leu Pro Asp Leu Val Lys Lys Ser Ile Lys Ile Tyr Cys Thr Asp 
                165                 170                 175     


Glu Lys Arg Lys Leu Asn Asp Arg Glu Glu Gln Glu Met Tyr Val Leu 
            180                 185                 190         


Phe Ser Tyr Met Tyr Glu Asp Lys Tyr Lys Asp Arg Gln Lys Val Leu 
        195                 200                 205             


Ile Ala Asn Ser Ile Ser Asn Gln Ala Thr Lys Val Lys Val Cys Asp 
    210                 215                 220                 


Asp Glu Ser Arg Leu Ile Lys Leu Ser Ile Ala Asp Thr Lys Lys Lys 
225                 230                 235                 240 


Pro Leu Trp Asp Phe Ile Val Asp Tyr Ala Asn Ser Asp Lys Asn Gly 
                245                 250                 255     


Gln Tyr Thr Ile Leu Arg Asn Ile Arg Lys Ser Ile Val Leu Phe Val 
            260                 265                 270         


Cys Gly Val Asp Val Tyr Arg Asn Ile Glu Asn Asn Asp Asn Leu Asp 
        275                 280                 285             


Ile Trp Lys Trp Glu Glu Tyr Gly Ile Gln Glu Ser Gln Leu Phe Val 
    290                 295                 300                 


Lys Ile Glu Asn Cys Tyr Thr Thr Lys Gly Glu Asp Ile Ala Leu Asn 
305                 310                 315                 320 


Glu Ile Arg Asn Val Asn Leu Asp His Tyr Met Lys Ala Ile Gly Val 
                325                 330                 335     


Leu Asp Asp Glu Arg Ser Lys Phe Trp Phe Gln His Tyr Glu Asn Thr 
            340                 345                 350         


Ile Glu Ala Leu Phe Ser Lys Lys Ser Lys Arg Lys Ile Glu Arg Ile 
        355                 360                 365             


Lys Thr Ala Tyr Leu Cys Glu Tyr Leu Trp Lys Asn Phe Cys Ser Tyr 
    370                 375                 380                 


Val Ala Leu Lys Tyr Val Asp Leu Gly Lys Gly Val Tyr His Phe Thr 
385                 390                 395                 400 


Met Ser Asp Lys Leu Ser Leu Met Asn Lys Asn Thr Asn Glu Asn Gly 
                405                 410                 415     


Ile Lys Phe Gly Glu Val Asp Ser Arg Phe Asn Lys Gly Ile Ser Ser 
            420                 425                 430         


Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Thr Ile Asp Arg Asn Ile 
        435                 440                 445             


Ser Thr Tyr Thr Thr Phe Ala Thr Asn Ile Phe Ala Lys Ser Val Ile 
    450                 455                 460                 


Lys Asp Ser Tyr Arg Gln Lys Lys Ala Gly Asn Ser Asp Ala Leu Gln 
465                 470                 475                 480 


Tyr Asp Asp Glu Thr Tyr Tyr Asn Arg Lys Ala Met Asn Pro Tyr Ala 
                485                 490                 495     


Leu Lys Arg Val Leu Arg Tyr Trp Gly Gly Gln Ser Arg Trp Lys Ser 
            500                 505                 510         


Glu Leu Glu Glu Leu Asn Val Ala Glu Leu Cys Ile Asp Ile Lys Asn 
        515                 520                 525             


Arg Leu Ser Lys Ile Arg Asn Ser Gly Val His Tyr Thr Ser Thr Ser 
    530                 535                 540                 


Ala Leu Lys Gly Asn Asp Asp Asp Ser Ile Val Gly Met Leu Ile Lys 
545                 550                 555                 560 


Lys Asp Phe Asp Asp Ile Lys Asp Val Tyr Ala Ser Lys Tyr Tyr Ser 
                565                 570                 575     


Asn Asn Val Trp Met Phe Tyr Asn Thr Asp Lys Ile Ser Lys Met Met 
            580                 585                 590         


Glu Tyr Leu Tyr Gln Asp Asp Ser Asn Ile Arg Asp Ala Gln Ile Pro 
        595                 600                 605             


Ala Phe Asn Ser Val Ile Lys Arg Lys Asp Met Ala Glu Val Ile Glu 
    610                 615                 620                 


Lys Ile Val Lys Lys Asn Ser Tyr Lys Thr Ile Lys Glu Pro Tyr Gln 
625                 630                 635                 640 


Arg Glu Lys Tyr Arg Ser Cys Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
                645                 650                 655     


Tyr Asn Arg Phe Ile Lys Gln Asp Asn Leu Lys Asp Gln Val Ile Gln 
            660                 665                 670         


Ile Ile Asp Ser Asn Thr Glu Leu Ile Gly Asp Asn Ser Arg Ala Val 
        675                 680                 685             


Asp Asn Leu Lys Lys Arg Ile His Asp Val Asp Ser Gln Thr Met Ser 
    690                 695                 700                 


Phe Gly Glu Leu Cys Gln Val Ile Met Thr Asp Tyr Asn Met Gln Asn 
705                 710                 715                 720 


Gln Glu Asn Lys Ser Ile Lys Ser Lys Glu Arg Gln Asp Lys Asp Arg 
                725                 730                 735     


Lys Asn Gly Ile Asp Asn Ser Tyr Lys His Phe Pro Leu Leu Leu His 
            740                 745                 750         


His Leu Ile Lys Val Ser Phe Leu Lys Phe Ile Lys Thr Asp Glu Lys 
        755                 760                 765             


Leu Ala Phe Ile Arg Glu Pro Arg Ile Thr Glu Trp Asp Lys Thr Leu 
    770                 775                 780                 


Glu Gln Phe Glu Ala Gln Ile Gln Thr Val Asp Ile Tyr Asn Ser Leu 
785                 790                 795                 800 


Lys Met Met Val Ala Glu Asn Lys Ser Leu Leu Asp Trp Tyr Thr Leu 
                805                 810                 815     


Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asp Val 
            820                 825                 830         


Lys Asn Tyr Ile Gln Tyr Leu Ser Asn Ile Asp Lys Arg Ala Gly Ser 
        835                 840                 845             


Val Lys Asn Asn Lys Ser Ala Ser Thr Glu Val Lys Ile Arg Gln Tyr 
    850                 855                 860                 


Ser Glu Ile Val Arg Ile Leu Asp Phe Ser Leu Gln Tyr Ile Gly Arg 
865                 870                 875                 880 


Val Ser Asn Asp Val Thr Asp Tyr Phe Val Asp Glu Asp Glu Tyr Ala 
                885                 890                 895     


Ala Phe Leu Ser Lys Tyr Val Glu Phe Ser Gly Asn Asp Ile Val Ser 
            900                 905                 910         


Met Lys Ala Phe Cys Gln Ser Arg Thr Ala Asn Gly Lys His Thr Ile 
        915                 920                 925             


Gly Leu Tyr Cys Asp Gly Ala Asn Pro Ile Met Asn Arg Asn Ile Ala 
    930                 935                 940                 


Tyr Ala Lys Met Tyr Gly Asn Asp Glu Ile Leu Ser Tyr Ile Tyr Asn 
945                 950                 955                 960 


Lys Val Thr Lys Lys Asp Ile Glu Lys Tyr Tyr Val Ser Gln Asp Asn 
                965                 970                 975     


Leu Glu Lys Val Phe Ala Asp Gly Lys Cys Gln Asp Val Gln Gln Gln 
            980                 985                 990         


Asn Ala Leu Cys Asp Phe Gln Lys  Met Lys Asn His Ile  Glu Leu Thr 
        995                 1000                 1005             


Glu Val  Ser Ile Tyr Thr Asp  Ile Leu Asn Asp Phe  Met Ala Gln 
    1010                 1015                 1020             


Phe Ile  Ser Trp Ala Tyr Leu  Arg Glu Arg Asp Leu  Met Tyr Phe 
    1025                 1030                 1035             


Gln Leu  Gly Leu Asn Tyr Ile  Arg Met Phe Tyr Gly  Thr Tyr Glu 
    1040                 1045                 1050             


Leu Glu  Glu Lys Tyr Tyr Lys  Leu His Gly Glu Asn  Ile Asn Ile 
    1055                 1060                 1065             


Glu Lys  Gly Ala Leu Leu Tyr  Gln Ile Val Ala Met  Tyr Ser His 
    1070                 1075                 1080             


Glu Leu  Pro Ile Tyr Lys Val  Asp Glu Ser Gly Ile  Ala Ile Leu 
    1085                 1090                 1095             


Ala Glu  Lys Gln Gly Ser Ser  Gly Ala Ser Ile Lys  Ser Phe Val 
    1100                 1105                 1110             


Thr Glu  Tyr Cys Lys Glu Glu  Met Lys Lys Ala Tyr  Thr Tyr Glu 
    1115                 1120                 1125             


Asn Gly  Leu Glu Leu Phe Glu  Asp Val Asn Gln His  Asp Asp Leu 
    1130                 1135                 1140             


Ser Lys  Leu Arg Asn Asp Phe  Ala His Met Arg Tyr  Met Ser Ala 
    1145                 1150                 1155             


Arg Asp  Lys Ser Ile Met Asp  Ile Val Ser Glu Ile  Tyr Asn Gly 
    1160                 1165                 1170             


Phe Phe  Ile Tyr Asp Thr Lys  Leu Lys Lys Ser Val  Ser Phe Ile 
    1175                 1180                 1185             


Phe Lys  Asn Ile Leu Met Arg  Tyr Ala Val Asp Val  Asn Ile Glu 
    1190                 1195                 1200             


Phe Cys  His Lys Gly Asp Asn  Glu Asp Thr Asn Asn  Leu Ile Arg 
    1205                 1210                 1215             


Ile Lys  Asp Glu Val Gly Leu  Tyr Ser Asp Lys Tyr  Thr Tyr Lys 
    1220                 1225                 1230             


Val Glu  Asp Asn Asp Thr Val  Asp Ile Glu Val Arg  Asn Ser Glu 
    1235                 1240                 1245             


Phe Leu  Glu Gln Leu Lys Lys  Leu Leu Glu Tyr Lys  Lys Glu Ser 
    1250                 1255                 1260             


Glu Gly  Ser Glu Leu 
    1265             


<210>  77
<211>  1163
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  77

Met Leu Val Ile Lys Pro Tyr Gly Arg Ser Asn Val Lys Lys Ala Ala 
1               5                   10                  15      


Ala Gly Glu Lys Ala Glu Asn Cys Trp Arg Ala Ile Arg Thr Val Glu 
            20                  25                  30          


Lys Asn Ser Gly Gln Ser Lys Ile Val Glu Arg Pro Ile Ala Gly Phe 
        35                  40                  45              


Ile Ala Glu Arg Asp Glu Ala Val Ile Ala Gln Trp Val Ser Ile Ile 
    50                  55                  60                  


Asp Lys Ile Ile Ala Lys Pro Gly Glu Lys Asp Ser Asn Asn Lys Ala 
65                  70                  75                  80  


Gln Glu Leu Arg Lys Ile Leu Ala Ala Ala Ala Trp Ala Val Ile Lys 
                85                  90                  95      


Ser Lys Asn Leu Leu Ala Lys Leu Ala Gly Thr Pro Ala Glu Arg Gln 
            100                 105                 110         


Glu Ile Glu Lys Ile Trp Gln Trp Lys Met Ala Ala Thr Gln Pro Lys 
        115                 120                 125             


Glu Pro Arg Ala Leu Glu Gly Arg Trp Tyr Glu Ala Phe Ala Ala Gly 
    130                 135                 140                 


Ile Pro Cys Asp Thr Gln His Ile Lys Ala Asp Ala Ala Lys Ile Ala 
145                 150                 155                 160 


Asp Arg Ile Tyr Ile His Leu Tyr Arg Gln Ala Tyr Arg Phe Pro Leu 
                165                 170                 175     


Lys Ser Lys Thr Ala Gln Gly Ser Ala Ala Gly Asp Ser Arg Cys His 
            180                 185                 190         


Gln Lys Gly Leu Ile Gln His Arg Ala Ser Ala Ile Ala Glu Asn Ile 
        195                 200                 205             


Leu His Ile Pro Ala Phe Leu Met Cys Ala Ala Asp Lys Glu Asp Tyr 
    210                 215                 220                 


Ser Asp Ser Asp Lys Glu Ala Tyr Ser Glu Asp Asp Lys Lys Asp Tyr 
225                 230                 235                 240 


Ser Ala Ala Ala Gly Asn Phe Ala Ala Glu Ile Lys Arg Ala Ile Leu 
                245                 250                 255     


Val Ser Glu Lys Leu Ser Arg Thr Asp Tyr Lys Asp Arg Pro Tyr Glu 
            260                 265                 270         


Ile Ala Ala Arg Ile Met Arg Glu Thr Gly Asp Arg Leu Phe Ala Cys 
        275                 280                 285             


Leu Gly Asp Lys Ala Gln Lys Pro Gly Leu Leu Ala Leu His Ser Gln 
    290                 295                 300                 


Ile Lys Ser Gly Tyr Lys Ala Leu Leu Lys Gly Arg Lys Gln Leu Lys 
305                 310                 315                 320 


Ala Arg Leu Glu Tyr Leu Leu Pro Gln Asp Asn Ala Ala Leu Phe Gln 
                325                 330                 335     


Leu Val Glu Ala Gln Gln Gln Asn Arg Tyr Ile Asn His Leu Ile Arg 
            340                 345                 350         


Leu Gly Lys Ile Val His Tyr Thr Ala Ile Val Pro Asp Thr Ala Ser 
        355                 360                 365             


Leu Ala Ala Leu Gln Ser Ser Pro Lys Thr Ile Ile Asn Asn Trp Pro 
    370                 375                 380                 


Gln Lys Glu Ala Val Glu Gly Ser Arg Phe Trp Ser Ser Ala Gly Gln 
385                 390                 395                 400 


Thr Glu Ile Lys Gln Asn Glu Ala Phe Val Arg Val Trp Arg Gly Ala 
                405                 410                 415     


Leu Ala Phe Ala Ala Arg Thr Val Lys Asp Trp Val Asp Pro Gln Asp 
            420                 425                 430         


Lys Ile Pro Gly Asp Ile Leu Leu Asn Gln Thr Thr Ala Leu Asp Asn 
        435                 440                 445             


Phe Asp Ala Asp Tyr Phe Glu Gln Lys Tyr Gln Ile Leu Phe Gly Asn 
    450                 455                 460                 


Lys Trp Glu Ala Glu Glu Asp Lys Lys Ala Leu Leu Glu Phe Ser Leu 
465                 470                 475                 480 


Ser Asn Leu Tyr Ala Leu Arg Asn Ala Ala Phe His Phe Ser Asn Leu 
                485                 490                 495     


Arg Leu Phe Val Glu Ala Leu Met Pro Lys Lys Ala Leu Glu Ala Glu 
            500                 505                 510         


Lys Leu Asp Lys Phe Leu Ala Thr Phe Tyr Thr Asp Ala Cys His Asn 
        515                 520                 525             


Tyr Gln Leu Lys Gln Lys Ala Ile Met Gln Gly Ala Gln Phe His Asp 
    530                 535                 540                 


Phe Phe Ser Glu Ala Glu Ile Glu Thr Ile Trp Gln Ala Leu Thr Ser 
545                 550                 555                 560 


Ala Gln Ala Ser Pro Leu Pro Val Pro Arg Leu Lys Arg Val Leu Glu 
                565                 570                 575     


Arg Ala Ala Asp Ala Trp Lys Gly Trp Asp Asn Arg Leu Gln Val Pro 
            580                 585                 590         


Pro Tyr Ser Thr Ala Glu Glu Arg Glu Ala Ser Ala Trp Ala Arg Cys 
        595                 600                 605             


Gln Tyr Thr Ala Ala Lys Leu Leu Tyr Asp Gly Pro Phe Lys Asn Trp 
    610                 615                 620                 


Leu Glu Gly Leu Gly Gln Ala Ala Leu Ser Gly Tyr Ile Asn Arg Ala 
625                 630                 635                 640 


Leu Glu His Thr Ser Gln Ala Ala Lys Lys Ile Lys Asn Gly Asp Lys 
                645                 650                 655     


Glu Phe Glu Glu Phe Ile Ile Ser Lys Ala Gly Lys Ile Ala Glu Leu 
            660                 665                 670         


Gly Asp Glu Asn Asp Phe Arg Asp Phe Phe Ser Thr Leu Thr Ala Ala 
        675                 680                 685             


Thr Ala Thr Glu Met Arg Val Gln Asn Phe Tyr Gln Ser Asp Gly Lys 
    690                 695                 700                 


Ala Ala Lys Lys Gln Ala Asp Tyr Ile Glu Lys Phe Lys Cys Asp Ile 
705                 710                 715                 720 


Val Ala Leu Ala Phe Ala Asp Tyr Val Arg Lys Val Ile Gly Leu Arg 
                725                 730                 735     


Asn Ile Ala Ala Phe Cys Asn Lys Glu Arg Thr Glu Lys Pro Gly Ser 
            740                 745                 750         


Ser Arg Ile Tyr Asp Arg Leu Pro Val Ser Val Lys Gln Asn Ser Thr 
        755                 760                 765             


Gly Ala Pro Trp Gln Ser Arg Leu Tyr Phe Leu Leu His Leu Met Pro 
    770                 775                 780                 


Val Glu Glu Ala Gly Ser Leu Arg Gln Gln Leu Lys Lys Trp Glu Ile 
785                 790                 795                 800 


Ile Thr Asp Lys Ser His Gly Lys Gly Ser Arg Gly Gly Thr Val Leu 
                805                 810                 815     


Thr Gln Leu Leu Ala Val Phe Asp Leu Tyr Ile Ala Met His Asp Ala 
            820                 825                 830         


Gln Phe Val Gly Ala Glu Leu Ala Ser Leu Glu Ser Asp Lys Glu Thr 
        835                 840                 845             


Ala Gln Ala Leu Phe Glu Asn Glu Gly Asp Phe Arg Gln Ile Phe Pro 
    850                 855                 860                 


Glu Lys Lys Asp Gly Ile Glu Asp Glu His Leu Pro Ile Arg Gly Leu 
865                 870                 875                 880 


Arg Glu Met Gln Arg Phe Gly Thr Ser Leu Leu His Asn Phe Tyr Glu 
                885                 890                 895     


Lys His Gln Ile Ser Glu Ala Ser Val Ala Arg Trp Gln Lys Leu Glu 
            900                 905                 910         


Lys Ile Ile Ala Gln Glu Gln Arg Lys Leu Lys Lys Leu His Gln Asp 
        915                 920                 925             


Trp Val Asn Ser Lys Lys Arg Lys Asn Asn Ile Lys Trp Lys Glu Glu 
    930                 935                 940                 


Asn Ala Tyr Glu Ala Ala Leu Lys Leu Val Thr Glu His Arg His Leu 
945                 950                 955                 960 


Thr Ala Arg Val Met Leu Gln Ser His Val Arg Leu His Arg Leu Leu 
                965                 970                 975     


Ile Lys Ile Leu Gly Arg Leu Val Asp Phe Ala Gly Leu Trp Glu Arg 
            980                 985                 990         


Asp Leu Tyr Phe Val Leu Leu Ala  Gln Leu Tyr Cys Lys  Gly Val Glu 
        995                 1000                 1005             


Asp Ile  Glu Glu Gln Phe Lys  Asp Lys Gly Ala Lys  Leu Gly Thr 
    1010                 1015                 1020             


Gly Gln  Ile Val Ala Ala Leu  Arg Lys Leu Lys Asp  Thr Gly Leu 
    1025                 1030                 1035             


Gln Ala  Lys Ile Ala Ser Leu  Leu Asn Gln Gln Glu  Thr Gln Glu 
    1040                 1045                 1050             


Ile Arg  Asn Gly Phe Asp His  Phe Asp Thr Leu Lys  Lys Lys Tyr 
    1055                 1060                 1065             


Phe Pro  Val Asn Leu Thr Ala  Glu Val Asn Lys Ala  Arg Arg Leu 
    1070                 1075                 1080             


Met Ala  Tyr Asp Arg Lys Leu  Lys Asn Ala Val Thr  Lys Ser Val 
    1085                 1090                 1095             


Ile Asp  Leu Leu Arg Arg Glu  Asn Ile Glu Leu Lys  Trp Ser Met 
    1100                 1105                 1110             


Gly Ala  Asp His Glu Leu Glu  Gly Val Leu Ser Ile  Phe Ser Ala 
    1115                 1120                 1125             


Lys Ala  Cys His Leu Ala Lys  Glu Tyr Gly Asn Asn  Lys Ile Ala 
    1130                 1135                 1140             


Glu Glu  Leu Cys Asp Ala His  Tyr Val Ala Met Ile  Glu Ser Leu 
    1145                 1150                 1155             


Leu Asn  Gly Asn Ser 
    1160             


<210>  78
<211>  1403
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  78

Met Lys Ile Val Arg Gly Tyr Gly Arg Ser Val Val Gly Lys Phe Ala 
1               5                   10                  15      


Glu Glu Asp Gly Ala Asp Ile Lys Asp Leu Lys Ile Arg Lys Leu His 
            20                  25                  30          


Lys Thr Gly Gly Asp Glu Asp Leu Ser Phe Ala Ala Phe Ala Arg Thr 
        35                  40                  45              


Glu Gly Glu Phe Ile Leu Ala Leu Trp Val Ser Val Ile Asp Lys Ile 
    50                  55                  60                  


Val Ala Lys Ala Thr Lys Asn Ala Glu Lys Gly Asn Glu Lys Ala Lys 
65                  70                  75                  80  


Asn Ala Ile Ala Lys Lys Leu Arg Gln Lys Ile Gly Ala Ala Ala Trp 
                85                  90                  95      


Gln Lys Leu Leu Arg Ala Asn Arg Leu Glu Leu Ala Ala Ile Trp Asn 
            100                 105                 110         


Trp Lys Ile Gly Ala Glu Ser Ser Ser Arg Gln Ser Glu Asn Phe Pro 
        115                 120                 125             


Gln Gly Asn Trp Tyr Pro Ala Phe Leu Gly Asn Ala Ala Pro Glu Gly 
    130                 135                 140                 


Leu Ser Asp Pro Gln Ile Thr Glu Leu Val His Asp Ile Asp Thr His 
145                 150                 155                 160 


Ile His Lys Ala Met Arg Gln Ile Gly Gly Val Glu Gly Lys Asp Lys 
                165                 170                 175     


Asn Arg Leu Arg Ser Glu Gly Leu Leu Ala Asp Ile Val Ala Ala Val 
            180                 185                 190         


Glu Lys Asn Thr Leu Lys Ser Ala His Glu Lys Gln Phe Pro Gln Gly 
        195                 200                 205             


Lys Lys Arg Asp Cys Ala Phe Ser Lys Glu Asp Trp Gln Val Tyr Arg 
    210                 215                 220                 


Asp Ala Ala Asn Lys Ala Val Gly Gly Asp Phe Val Ala Asp Leu Lys 
225                 230                 235                 240 


Gly Ala Val Leu Asn Thr Ala Asp Lys Asp Lys Pro Tyr His Lys Ala 
                245                 250                 255     


Ile Glu Tyr Leu Lys Lys Val Val Trp Pro Gln Ile Phe Cys Asp Glu 
            260                 265                 270         


Asn Gly Ala Val Leu Gly Arg Lys Gln Ala Thr Glu Gln Met Pro Lys 
        275                 280                 285             


Leu Leu Val Val His Asp Ala Ile Thr Ala Tyr Tyr Lys Lys Leu Leu 
    290                 295                 300                 


Lys Asp Arg Gly Ser Ile Ala Gly Tyr Lys Val Lys Glu Lys Gly Glu 
305                 310                 315                 320 


Asn Tyr Glu Lys Ala Thr Gly Ile Lys Arg Gln Gly Glu Lys Ala Pro 
                325                 330                 335     


Ala Lys Leu Glu Leu Leu Leu Pro Ala Ser Val Asn Lys Leu Lys Trp 
            340                 345                 350         


Ile Leu Cys Lys Gln His Glu Asn Arg Asp Val Asn His Tyr Ile Arg 
        355                 360                 365             


Leu Gly Lys Val Leu His Tyr Thr Ala Ser Gln Phe Ser Asn Glu Asn 
    370                 375                 380                 


Gln Asp Ser Ala Ala Tyr Ile Ile Gly Asn Trp Asp Lys Ala Val Glu 
385                 390                 395                 400 


Ala Leu Pro Thr Ser Pro Tyr Trp Thr Ser Glu Gly Gln Thr Gln Ile 
                405                 410                 415     


Lys Gln Asn Glu Ala Phe Ile Arg Val Trp Arg Arg Val Leu Ala Phe 
            420                 425                 430         


Ala Val His Ser Leu Lys Asn Trp Ala Asp Pro Asp Asn Lys Val Ala 
        435                 440                 445             


Gly Asp Pro Thr Ile Lys Pro Thr Trp Gly Glu Ile Gln Lys Asn Phe 
    450                 455                 460                 


Ala Asp Ser Ser Phe Ala Gln Lys Phe Ala Gln Lys Tyr Glu Leu Phe 
465                 470                 475                 480 


Phe Gly Lys Ile Trp Gln Gly Ser Lys Gln Leu Glu Leu Leu Asp Tyr 
                485                 490                 495     


Leu Gln Glu Arg Leu Met Glu Leu Arg Gly Ser Val Phe His Phe Lys 
            500                 505                 510         


Gly Leu Arg Lys Phe Thr Ser Glu Leu Lys Ala Lys Asn Pro Pro Gln 
        515                 520                 525             


Leu Met Arg Asp Phe Tyr Glu Asp Asp Cys Gln Ala Tyr Arg Ala Lys 
    530                 535                 540                 


Pro Leu Lys Ile Met Gln Gly Ala Lys Phe Glu Arg Phe Phe Ser Lys 
545                 550                 555                 560 


Glu Gln Ile Glu Glu Met Leu Glu Ala Ala Gln Ala Trp Asp Ala Val 
                565                 570                 575     


Ser Val Thr Ala Pro Lys Gly Asp Asp Gly Gln Gln Leu Pro Leu Pro 
            580                 585                 590         


Thr Leu Lys Arg Leu Leu Val Arg Val Lys Asn Thr Trp Ser Glu Asp 
        595                 600                 605             


Gly Glu Gly Asn Ile Ala Leu Pro Pro Tyr Asp Ser Ala Ala Lys Lys 
    610                 615                 620                 


Asn Glu Lys Ala Asp Lys Ala Ala Glu Asn Glu Val Ser Val Glu Thr 
625                 630                 635                 640 


Lys Ala Ala Glu Thr Asp Asp Glu Lys Arg Glu Lys Ala Arg His Ala 
                645                 650                 655     


Gln Tyr Ile Ala Ile Lys Gln Leu Tyr Glu Leu Pro Phe Arg Ala Trp 
            660                 665                 670         


Leu Ala Lys Leu Ser Pro Glu Lys Val Asn Asp Tyr Ile Asp Arg Ala 
        675                 680                 685             


Val Lys Arg Ala Lys Ala Ala Ala Gln Glu Asn Glu Pro Asp Glu Glu 
    690                 695                 700                 


Val Lys Lys Cys Ile Val Ala Arg Ala Ala Ser Leu Pro Arg Leu Lys 
705                 710                 715                 720 


Ala Lys Glu Arg Ile Asp Gly Phe Phe Tyr Asn Leu Met Ala Glu Thr 
                725                 730                 735     


Ala Ser Glu Met Arg Val Gln Lys Asp Tyr Ser Ser Asp Gly Glu Gln 
            740                 745                 750         


Ala Lys Lys Gln Ala Lys Tyr Ile Glu Asn Leu Lys Cys Asp Val Ile 
        755                 760                 765             


Ala Tyr Ala Leu Ala Asp Tyr Leu Gln Ala Lys His Glu Val Glu Glu 
    770                 775                 780                 


Lys Gly Lys Gln Thr Lys Leu Val Cys Phe Lys Tyr Val Leu Gly Glu 
785                 790                 795                 800 


Gly Glu Ala Lys Gly Ser Ala Glu Lys Ala Tyr Leu Leu Pro Ala Arg 
                805                 810                 815     


Pro Asp Ala Pro Gln Asp Lys Glu Lys Val Lys Val Phe Trp Ala Gly 
            820                 825                 830         


Ile Thr Thr Gly Gln Ile Thr Thr Asp Lys Asn Glu Ala Trp Asn Lys 
        835                 840                 845             


Leu Thr Glu Glu Gly Lys Phe Leu Pro Trp Leu Tyr Phe Leu Leu His 
    850                 855                 860                 


Leu Ala Pro Val Glu Glu Val Ala Gly Leu Arg Gln Gln Ile Arg Lys 
865                 870                 875                 880 


Trp Gln Ile Val Val Thr Lys Leu Glu Ile Asp Lys Thr Gly Asp Glu 
                885                 890                 895     


Asp Ser Gly Lys Lys Gln Ala Gly Lys Lys Ala Glu Ala Ala Lys Val 
            900                 905                 910         


Arg Ser Leu Leu Cys Ala Leu Asn Leu Tyr Ile Glu Leu His Asp Glu 
        915                 920                 925             


Gln Phe Asn Gln Gly Gly Gln Asn Lys Arg Glu Phe Ser Pro Glu Asp 
    930                 935                 940                 


Arg Glu Lys Leu Arg Asp Tyr Tyr Ile Gly Glu Gln Asp Tyr Lys Ser 
945                 950                 955                 960 


Val Val Asn Arg Gln Lys Asp Asn Ala Asp Asn Glu Gln Met Ile Arg 
                965                 970                 975     


Gly Leu Arg Glu Met Arg Arg Phe Gly Gly Asp Thr Ala Leu Asp Lys 
            980                 985                 990         


Ile Leu Glu Glu Lys Glu His Gln  Ile Ser Pro Asp His  Ile Lys Ala 
        995                 1000                 1005             


Trp Lys  Glu Asn Ser Asp Lys  Ile Ala Ala Ala Gln  Asn Thr Arg 
    1010                 1015                 1020             


Lys Glu  Arg His Lys Glu Trp  Ala Lys Leu Glu Asn  Lys Val Asn 
    1025                 1030                 1035             


Lys Glu  Trp Trp Asp Ser Lys  Lys Lys Gly Lys Asn  Thr Asn Tyr 
    1040                 1045                 1050             


Lys Leu  Gly Asp Lys Gly Gln  Val Tyr Ala Ala Ala  Leu Glu Thr 
    1055                 1060                 1065             


Ile Ile  Lys His Ser Glu Ala  Val Ala Gln Ile Glu  Leu His Asn 
    1070                 1075                 1080             


Gln Leu  Asn Leu His Lys Leu  Leu Leu Ala Val Leu  Gly Arg Leu 
    1085                 1090                 1095             


Val Asp  Phe Ser Gly Leu Phe  Glu Arg Asp Leu Tyr  Phe Thr Met 
    1100                 1105                 1110             


Leu Ala  Leu Phe Tyr Glu Asn  Lys Val Glu Arg Leu  Glu Asp Lys 
    1115                 1120                 1125             


Phe Glu  Asp Ser Gly Ala Leu  Leu Lys Gln Gly Arg  Ile Pro Glu 
    1130                 1135                 1140             


Ala Phe  Ala Glu Gln Leu Lys  Glu Gly Lys Glu Lys  Glu Asp Leu 
    1145                 1150                 1155             


Lys Lys  Ile Phe Ser Asn Lys  Lys Leu Ala Gly Lys  Asp Val Leu 
    1160                 1165                 1170             


Met Trp  Ile Arg Asn Arg Phe  Ala His Leu Ala Val  Leu Glu Ser 
    1175                 1180                 1185             


Lys Asp  Ile Asp Val Thr Arg  Glu Leu Asn Phe Ala  Arg Ala Leu 
    1190                 1195                 1200             


Met Ser  Tyr Asp Arg Lys Leu  Lys Asn Ala Val Thr  Lys Ser Val 
    1205                 1210                 1215             


Ala Glu  Met Leu Ala Arg His  Lys Leu Glu Ile Leu  Trp Gln Met 
    1220                 1225                 1230             


Gly Lys  Glu Gln His Ser Ala  Gly Ser Gly Asp Ser  Lys Asp Ser 
    1235                 1240                 1245             


Val Ala  Ile Ala Asp Lys Lys  Ile Lys Val Lys Ser  Gly His Tyr 
    1250                 1255                 1260             


Leu His  Gly Ala Lys Val Glu  Pro Arg Ile Ile His  His Leu Gly 
    1265                 1270                 1275             


Asp Asn  Lys Ala Glu Asp Leu  Gln Glu Ser Leu Gln  Asn Lys Glu 
    1280                 1285                 1290             


Phe Thr  Ser Met Val Gln Met  Leu Phe Gly Gly Gly  Asn Lys Leu 
    1295                 1300                 1305             


Lys Ala  Asp Lys Glu Ala Lys  Glu Lys Ala Glu Ala  Glu Lys Lys 
    1310                 1315                 1320             


Lys Arg  Thr Glu Glu Ala Gln  Lys Lys Gly Lys Gln  Ser Gly Val 
    1325                 1330                 1335             


Val Lys  Phe Phe Asn Ala Asp  Lys Gly Phe Gly Phe  Ile Lys Pro 
    1340                 1345                 1350             


Asp Asn  Gly Ser Ala Asp Ile  Phe Val His Val Ser  Ala Val Gln 
    1355                 1360                 1365             


Ala Ser  Gly Leu Met Ser Leu  Gln Glu Gly Gln Lys  Val Ser Tyr 
    1370                 1375                 1380             


Glu Thr  Glu Ala Asp Lys Arg  Gly Lys Gly Pro Lys  Ala Val Lys 
    1385                 1390                 1395             


Leu Ser  Ile Ile Glu 
    1400             


<210>  79
<211>  1172
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  79

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Ser 
    1145                 1150                 1155             


Asn Val  Ser Ser Ser Trp Ile  Leu Leu Tyr Gly Ile  Met Cys 
    1160                 1165                 1170         


<210>  80
<211>  1357
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  80

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Pro Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Lys Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Asp Ile Gln Lys Ile Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Lys Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Cys Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Thr Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Phe 
                325                 330                 335     


Asn Gly Leu Glu Glu Leu Glu Asn Leu Ser Gln Gln Lys Lys Glu Lys 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Arg Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Cys Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Lys 
                405                 410                 415     


Arg Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Ala Leu Glu Gly Glu Ser 
    450                 455                 460                 


Val Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Glu Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Ala Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Arg Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Lys Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Lys Gly Asp Lys Glu Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Glu Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Ser Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Lys Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Ala Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Val Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Glu Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Glu Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Met Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Val Leu Val Pro Ala  Arg Ser Glu 
    1325                 1330                 1335             


Val Phe  Leu Lys Gln Phe Arg  Lys Ile Leu Glu Tyr  Arg Ile Gln 
    1340                 1345                 1350             


Asp Lys  Thr Gln 
    1355         


<210>  81
<211>  1389
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  81

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Lys Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Phe Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn Gln Ile Gln Thr Gly Thr Lys Pro Lys Glu Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Lys Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Asn Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Gln Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Val Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Leu 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Tyr Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Met Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Ala Val Gly Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp Leu Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ala Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Tyr Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Phe Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Leu Tyr Leu Gln Asn Asn Lys Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asp Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Met Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Ile Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Cys Ile  Ser Ser Ile Lys Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Thr Leu Ile Thr Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Leu Leu Tyr  Tyr Pro Asp 
    1310                 1315                 1320             


Ile Glu  Ser Asn Val Lys Ile  Leu Leu Arg Lys Asp  Asn Phe Asn 
    1325                 1330                 1335             


Gln Asn  Lys Asp Lys Lys Asn  Val Asn Asn Arg Lys  Thr Lys Asn 
    1340                 1345                 1350             


Asn Asn  Lys Asn Gly Asn Arg  Asn Arg Asp Lys Asn  Arg Asp Lys 
    1355                 1360                 1365             


Asn Ser  Gly Gly Asp Gly Leu  Thr Tyr Asn Pro Phe  Leu Asn Leu 
    1370                 1375                 1380             


Ile Phe  Asp Leu Pro Glu 
    1385                 


<210>  82
<211>  1425
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  82

Met Lys Leu Ser Lys Val Asp Arg Ile Arg Val Ala Val Gly Lys Thr 
1               5                   10                  15      


Gly Lys Thr Glu Asn Gly Asn Ser Gln Gly Arg Gly Val Leu Tyr Arg 
            20                  25                  30          


Ser Pro Lys Gly Asn Lys Thr Val Ala Val Asp Ala Val Val Glu Glu 
        35                  40                  45              


Arg Ile Arg Asn Ala Asn Arg Leu Tyr Ser Ala Phe Phe Arg Cys Ala 
    50                  55                  60                  


Tyr Pro Glu Glu Pro Glu Arg His Phe Glu Glu Ile Ile Lys Arg Met 
65                  70                  75                  80  


Ala Thr Gly Lys Lys Ser Gly Ala Gln Ile Leu Lys Glu Tyr Ile Gly 
                85                  90                  95      


Tyr Glu Gly Gln Lys Asn Arg Lys Pro Tyr Thr Phe Tyr Val Asn Lys 
            100                 105                 110         


Cys Ala Tyr Arg Pro Ala Gly Lys Glu Leu Gly Gln Val Leu Arg Leu 
        115                 120                 125             


Phe Val Lys Glu Arg Leu Gly Gln Asn Trp Gln Asn Pro Glu Ala Ala 
    130                 135                 140                 


Glu Ala Ala Val Ala Leu Leu Thr Cys Leu Cys Glu Gly Lys Thr Asn 
145                 150                 155                 160 


Arg Tyr Thr Glu Asn Thr Ala Asp Gly Pro Val Leu Thr Glu Leu Ser 
                165                 170                 175     


Glu Gln Thr Val Thr Gln Leu Glu Gln Val Ser Arg Leu Gly Gly Ser 
            180                 185                 190         


Ile Leu Val Pro Lys Thr Glu Arg Leu Glu Thr Ile Val Thr Val Ile 
        195                 200                 205             


Leu Arg Leu Thr Ala Glu Gln Cys Asn Thr Ser Leu Tyr Val Asn Gly 
    210                 215                 220                 


Gly Thr Lys Glu Ala Gln Asp Ala Asp Leu Glu Lys Gln Ile Ala Leu 
225                 230                 235                 240 


Leu Lys Ser Leu Gln Thr Lys Pro Leu Leu Leu Lys Glu Arg Phe Asp 
                245                 250                 255     


Lys Val Thr Lys Gln Thr Ile Arg Asp Glu Gln Lys Leu Ser Glu Phe 
            260                 265                 270         


Ser Tyr Lys Asp Ala Thr Lys Glu Arg Met Glu Ala Val Val Val Arg 
        275                 280                 285             


Met Arg Lys Thr Leu Lys Lys Gly Ala Ser Arg Glu Val Ala Val Glu 
    290                 295                 300                 


Leu Leu Gln Ala Leu Ala Gln Tyr Asp Gly Lys Thr Trp Asp Gly Trp 
305                 310                 315                 320 


Leu Thr Gln Met Leu Glu Thr Glu Ala Ser Lys Lys Lys Leu Lys Asp 
                325                 330                 335     


Phe Ile Leu Ala Val Asn Lys Asp Phe His His Phe His Val Ile Lys 
            340                 345                 350         


Ser Val Lys Asn Thr Ala Val Ala Val Ser His Ser Glu Asp Asn Thr 
        355                 360                 365             


Leu Gln Leu Ser Gly Ala Lys Lys Lys Thr Lys Gly Ala Met Gln Asp 
    370                 375                 380                 


Ala Leu Phe Ala Tyr Ala Gln Ser Glu Glu Ser Ser Asp Glu Thr Leu 
385                 390                 395                 400 


His Arg Ile Lys Arg Ile Leu Phe Thr Tyr Val Leu Gly Gly Arg Gln 
                405                 410                 415     


Asp Asn Thr Leu Arg Leu Thr Glu Lys Thr His Leu Ala Lys Glu Leu 
            420                 425                 430         


Leu Trp Lys Phe Arg Gly Thr Gly Ala Gly Leu Phe Asp Ala Asp Phe 
        435                 440                 445             


Val Pro Glu Glu Glu Arg Ala Gly Glu Ser Gly Arg Lys Ala Gly Ser 
    450                 455                 460                 


Tyr Thr Asp Leu Gly Cys Leu Phe Ala Glu Asp Asp Gly Ile Arg Asn 
465                 470                 475                 480 


Gln Arg Arg Ile Ala Asp Arg Ile Asn Tyr Val Asn Tyr Gly Asn Tyr 
                485                 490                 495     


Leu Arg Met Arg Lys Ala Ala Glu Asp Glu Phe Thr Leu Phe Trp Cys 
            500                 505                 510         


Ala Tyr Ile Lys Asp Tyr Ile Glu Glu Asn Tyr Val Thr Lys Ile Arg 
        515                 520                 525             


Glu Ala Lys Arg Thr Gly Gly Lys Arg Arg Leu Lys Glu Thr Asp Cys 
    530                 535                 540                 


Glu Ala Glu Arg Met Met Glu Lys Cys Trp His Asp Ile Ile Arg Tyr 
545                 550                 555                 560 


Ile Cys Gly Lys Tyr Ile His Ile Gly Lys Ala Val Tyr His Phe Ala 
                565                 570                 575     


Ile Pro Glu Asp Leu Leu Ala Asn Pro Gly Glu Val Arg Ser Phe Gly 
            580                 585                 590         


Asp Val His Ala Lys Tyr Ala Asp Gly Ile Thr Ser Phe Asp Tyr Glu 
        595                 600                 605             


Asp Ile Lys Ala Glu Glu Asn Leu Gln Lys Ser Ile Phe Asn Val Leu 
    610                 615                 620                 


Val Ser Ala Val Ala Asn Tyr Ser Arg Ser Val Val Asp Leu Ser Ser 
625                 630                 635                 640 


Glu Arg Ala Glu Glu Leu Arg Arg Leu Pro Gly Asn Glu Arg Leu Asn 
                645                 650                 655     


Glu Asp Val Leu Met Met Lys Glu Thr His Leu Lys Glu Leu Leu Leu 
            660                 665                 670         


Pro Asp Ala Lys Lys Arg Leu Leu Arg Tyr Phe Gly Gly Tyr Ser Ala 
        675                 680                 685             


Cys Glu Gly Leu Ser Gly Val Thr Ser Glu Glu Leu Ala Trp Glu Met 
    690                 695                 700                 


Arg Thr Val Leu Ser Thr Leu Arg Asn Glu Ser Phe His Tyr Thr Phe 
705                 710                 715                 720 


Gly Lys Lys Lys Lys Leu Asp Tyr Lys Val Ala Lys Gln Leu Trp Met 
                725                 730                 735     


Gln Ala Ile Arg Ala Asn Arg Gln Leu Ile Leu Asp Lys Tyr Tyr Ser 
            740                 745                 750         


Asn Asn Thr Cys Arg Tyr Tyr Ser Pro Asn Ser Ile Lys Ala Leu Ile 
        755                 760                 765             


Glu Gln Gly Tyr Arg Ser Tyr Glu Glu Arg Glu Ala Gln Ile Pro Ala 
    770                 775                 780                 


Phe Lys Thr Val Trp Lys Lys Ala Glu Leu Ala Lys Tyr Leu Ala Asp 
785                 790                 795                 800 


Lys Lys Val Met Pro Ala Glu Ile Ser Gly Glu Glu Lys Glu Arg Val 
                805                 810                 815     


Ile Phe Gln Gly Ala Phe Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg 
            820                 825                 830         


Glu Phe Thr Val Gly Asn Thr Ala Ala Lys Tyr Phe Phe Asp Ala Val 
        835                 840                 845             


Glu Arg Tyr Cys Lys Glu Asn Glu Thr Gly Pro Tyr Lys Asn Pro Ala 
    850                 855                 860                 


Lys Ser Phe Asn Asp Tyr Val Asn Gly Ala Phe Asn Asn Lys Gly Val 
865                 870                 875                 880 


Lys Val Gln Lys Gly Leu Ser Asp Leu Tyr Arg Glu Gly Lys Ile Thr 
                885                 890                 895     


Phe Gly Val Val Cys Gln Thr Ile Met Ala Glu Tyr Thr Gln Gln Asn 
            900                 905                 910         


Glu Lys Ser Glu Gly Glu Ala Ile Tyr Gln His Phe Lys Met Leu Phe 
        915                 920                 925             


Pro Leu Cys Met Arg Lys Gly Phe Gln Lys Tyr Val Glu Glu Lys His 
    930                 935                 940                 


Lys Glu Leu Leu Gln Pro Val Ile Arg Glu Met Gly Ser Arg Glu Asp 
945                 950                 955                 960 


Phe Leu Thr Asn Ile His Ile Gly Cys Phe Asp Asp Phe Cys Arg Glu 
                965                 970                 975     


Asp Gly Met Tyr Glu Tyr Asp Trp Phe Val Val Ala His Leu Ile His 
            980                 985                 990         


Pro Lys Arg Leu Asn Glu Leu Val  Gly Asn Leu Lys Asp  Tyr Met Gln 
        995                 1000                 1005             


Phe Lys  Gln Asp Ile Leu Arg  Arg Ala Asp Tyr Val  Glu Gln Phe 
    1010                 1015                 1020             


Thr Lys  Glu Glu Leu Ala Ala  Met Lys Ala Arg Thr  Glu Glu Lys 
    1025                 1030                 1035             


Leu Gln  Lys Ile Ser Gly Ile  Leu Arg Val Ala Glu  Phe Val Arg 
    1040                 1045                 1050             


Gly Ile  Ala Gly Arg Val Ser  Asn Thr Phe Ser Asp  Tyr Tyr Glu 
    1055                 1060                 1065             


Ser Glu  Glu Ala Tyr Ala Ser  Tyr Leu Glu Gln Tyr  Ile Glu Phe 
    1070                 1075                 1080             


Pro Arg  Ile Lys Gly Ser Thr  Val Phe Glu Ser Phe  Arg Asp Phe 
    1085                 1090                 1095             


Cys Val  Asn Thr Leu Pro Gly  Gly Ala Val Met Asp  Val Tyr Met 
    1100                 1105                 1110             


Asp Glu  Lys Asn Pro Arg Ile  Leu Arg Asn Val Glu  Val Ala Arg 
    1115                 1120                 1125             


Met Tyr  Ala Gly Gly Asp Ile  Gly Leu Arg Thr Arg  Lys Lys Val 
    1130                 1135                 1140             


Thr Ala  Glu Glu Leu Lys Arg  Tyr Tyr Gln Asn Glu  Ala Glu Val 
    1145                 1150                 1155             


Ala Ala  Leu Leu Lys Ala Gly  Leu Cys Ala Thr Ala  Glu Asp Gln 
    1160                 1165                 1170             


Lys Arg  Val Lys Ala Gln Gln  Glu Leu Arg Asn Arg  Ile Thr Leu 
    1175                 1180                 1185             


Thr Asp  Val Thr Glu Ile Gln  Glu Val Ile Asn Asp  Leu Leu Ser 
    1190                 1195                 1200             


Gln Leu  Val Thr Phe Ser Tyr  Phe Arg Glu Arg Asp  Glu Met Tyr 
    1205                 1210                 1215             


Leu Leu  Leu Gly Phe Tyr Tyr  Met Ala Leu Gln Ser  Asp Gly Asp 
    1220                 1225                 1230             


Trp Gly  Glu Glu Leu Arg Val  Phe Asp Gly Lys Lys  Leu Gln Val 
    1235                 1240                 1245             


Glu Asn  Gly Phe Val Leu Tyr  Gln Leu Leu Ser Ala  Phe Thr Tyr 
    1250                 1255                 1260             


Gly Leu  Asn Met Tyr Ser Glu  Ala Ala Pro Asp Gly  Lys Gly Gly 
    1265                 1270                 1275             


Ser Gln  Ala Gly Lys Ile Gly  Glu Phe Ile Lys Ala  His Pro Asn 
    1280                 1285                 1290             


Ser Trp  Asp Arg Ala Leu Arg  Leu Phe Val Asp Asp  Gly Ala Cys 
    1295                 1300                 1305             


Glu Glu  Val Ser Arg Lys Ala  Arg Asn Tyr Val Asp  His Phe Arg 
    1310                 1315                 1320             


Tyr Tyr  Val Lys Pro Asp Arg  Ser Ile Met Asp Leu  Tyr Ala Val 
    1325                 1330                 1335             


Tyr His  Glu Tyr Phe Phe Asp  Tyr Ser Thr Lys Met  Arg Lys Ser 
    1340                 1345                 1350             


Val Leu  Gln Asn Phe Ala Ser  Ile Leu Glu Arg Tyr  Phe Val Leu 
    1355                 1360                 1365             


Thr Lys  Phe Lys Leu Gly Gly  Glu Arg Gly Ala Gln  Thr Leu Glu 
    1370                 1375                 1380             


Ala Glu  Leu Ser Gly Asp Lys  Phe Thr Tyr Lys Leu  Ser Asp Thr 
    1385                 1390                 1395             


Lys Ala  Lys Pro Val Val Leu  Pro Ala Arg Asn Lys  Glu Phe Leu 
    1400                 1405                 1410             


Glu Asn  Leu Lys Asn Glu Leu  Asn Tyr Arg Gln Glu  
    1415                 1420                 1425 


<210>  83
<211>  1249
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  83

Met Lys Ile Thr Lys Ile Asp Gly Val Ser His Tyr Lys Glu Lys Glu 
1               5                   10                  15      


Lys Gly Val Leu Lys Gly Lys Asp Ile Leu Asn Gly Lys Ile Glu Lys 
            20                  25                  30          


Ile Val Lys Lys Arg Tyr Asp Ala Thr Ile Glu Ser Lys Ile Tyr Lys 
        35                  40                  45              


Glu Phe Ile Lys Leu Arg Lys Asn Arg Ile Glu Gln Asn Asn Glu Lys 
    50                  55                  60                  


Ser Ile Leu Lys Leu Ile Lys Leu Asn Ile Asp Lys Asn Glu Lys Glu 
65                  70                  75                  80  


Ile Lys Thr Leu Leu Leu Asn Lys Phe Lys Ile Lys Glu Lys Asn Lys 
                85                  90                  95      


Lys Tyr Asp Lys Tyr Met Leu Asp Glu Asn Lys Leu Asp Asn Asp Ile 
            100                 105                 110         


Lys Ile Tyr Glu Ser Val Glu Ser Leu Tyr Phe Leu Ile Lys Glu Ile 
        115                 120                 125             


Tyr Leu Gly Gln Asn Asn Lys Lys Trp Asn Ile Ser Lys Ile Asp Leu 
    130                 135                 140                 


Glu Lys Ile Met Glu Glu Asp Asn Asn Leu Ile Met Leu Gly Tyr Lys 
145                 150                 155                 160 


Leu Lys Lys Asn Ile Thr Glu Asn Asp Tyr Pro Tyr Leu Tyr Ser Asp 
                165                 170                 175     


Lys Asn Gly Gln Glu Ser Thr Ser Val Tyr Lys Leu Leu Lys Lys Leu 
            180                 185                 190         


Ile Glu Glu Asn Lys Asp Arg Asn Gln Asp Ile Arg Lys Ser Gln Glu 
        195                 200                 205             


Tyr Glu Lys Ile Arg Lys Asn Phe Glu Glu Tyr Lys Asn Arg Lys Ile 
    210                 215                 220                 


Asn Leu Leu Val Lys Ser Ile Lys Asn Asn Lys Ile Asn Ile Gln Tyr 
225                 230                 235                 240 


Ile Asn Asn Glu Ile Lys Ser His Asn Asn Ser Arg Glu Glu Asn Ile 
                245                 250                 255     


Ile Lys Phe Phe Lys Lys Met Ile Glu Glu Lys Asn Glu Pro Ile Leu 
            260                 265                 270         


Lys Asp Lys Leu Lys Leu Phe Lys Leu Glu Val Phe Phe Asp Glu Glu 
        275                 280                 285             


Phe Leu Glu Glu Ile Lys Lys Leu Leu Asp Ser Asp Asp Phe Asp Lys 
    290                 295                 300                 


Ser Tyr Asn Lys Lys Ile Ser Glu Leu Arg Gly Lys Ile Phe Asn Arg 
305                 310                 315                 320 


Ile Arg Glu Lys Ile Lys Asn Asn Lys Asn Arg Asp Glu Leu Glu Asn 
                325                 330                 335     


Ile Tyr Phe Leu Glu Leu Lys Lys Tyr Ile Glu Asn Asn Leu Ser His 
            340                 345                 350         


Lys Lys Glu Lys Asn Lys Asn Asn Asn Asn Thr Gly Glu Glu Lys Ser 
        355                 360                 365             


Lys Glu Leu Tyr Leu Lys Phe Leu Lys Lys Val Leu Phe Ile Asp Asp 
    370                 375                 380                 


Asn Asn Arg Ile Ser Ile Glu Lys Leu Lys Ser Arg Ile Asp Asp Asn 
385                 390                 395                 400 


Phe Lys Asn Leu Leu Ile Gln His Val Ile Glu Tyr Gly Lys Ile Lys 
                405                 410                 415     


Tyr Tyr Val Glu Asn Asp Asp Tyr Ile Arg Asn Ile Val Lys Asn Gly 
            420                 425                 430         


Glu Leu Lys Leu Glu Thr Lys Asp Leu Glu Tyr Ile Lys Thr Lys Glu 
        435                 440                 445             


Thr Leu Ile Arg Lys Met Ala Val Leu Val Ser Phe Ala Ala Asn Ser 
    450                 455                 460                 


Tyr Tyr Asn Leu Phe Gly Ser Val Ser Glu Asp Ile Leu Gly Thr Glu 
465                 470                 475                 480 


Val Val Lys Asn Arg Arg Thr Asn Val Ile Lys Val Lys Ser Tyr Ile 
                485                 490                 495     


Phe Lys Glu Lys Met Leu Asn Tyr Phe Phe Asp Ser Glu Asp Phe Asp 
            500                 505                 510         


Ile Asn Lys Thr Ile Glu Val Leu Glu Ser Ile Ser Tyr Ser Ile Tyr 
        515                 520                 525             


Asn Ile Arg Asn Gly Val Gly His Phe Asn Lys Leu Val Leu Gly Lys 
    530                 535                 540                 


Tyr Lys Lys Lys Asp Ile Asn Thr Asn Lys Arg Val Glu Glu Asp Leu 
545                 550                 555                 560 


Asn Asn Asn Glu Glu Ile Lys Gly Tyr Phe Ile Gln Lys Arg Gly Glu 
                565                 570                 575     


Ile Glu Lys Lys Ile Lys Glu Arg Phe Leu Ser Asn Asn Leu Gln Tyr 
            580                 585                 590         


Tyr Tyr Ala Lys Glu Arg Ile Glu Asn Tyr Phe Glu Val Tyr Glu Phe 
        595                 600                 605             


Glu Ile Leu Lys Glu Lys Ile Pro Phe Ala Pro Asn Phe Lys Arg Ile 
    610                 615                 620                 


Ile Lys Lys Gly Glu Asp Leu Phe Asn Asn Lys Lys Asn Lys Lys Tyr 
625                 630                 635                 640 


Glu Tyr Phe Lys Asn Phe Asp Lys Asn Ser Ala Glu Glu Lys Lys Glu 
                645                 650                 655     


Phe Leu Lys Thr Arg Asn Phe Leu Leu Lys Glu Leu Tyr Tyr Asn Asn 
            660                 665                 670         


Phe Tyr Lys Glu Phe Leu Ser Lys Lys Glu Glu Leu Lys Lys Ile Val 
        675                 680                 685             


Ile Glu Val Lys Glu Glu Lys Lys Asn Arg Gly Asn Asn Lys Lys Ser 
    690                 695                 700                 


Gly Val Ser Phe Gln Asn Ile Asp Asp Tyr Asp Thr Lys Ile Asn Ile 
705                 710                 715                 720 


Ser Asp Tyr Ile Ala Ser Ile His Lys Lys Glu Met Glu Arg Val Glu 
                725                 730                 735     


Lys Tyr Asn Glu Glu Lys Gln Lys Asp Thr Ala Lys Tyr Ile Arg Asp 
            740                 745                 750         


Phe Val Glu Glu Ile Phe Leu Thr Gly Phe Ile Asn Tyr Leu Glu Lys 
        755                 760                 765             


Asp Glu Arg Leu His Phe Leu Lys Glu Glu Phe Ser Val Leu Cys Asn 
    770                 775                 780                 


Ser Asn Asn Asn Val Ile Asp Phe Asn Val Asn Ile Asn Glu Glu Lys 
785                 790                 795                 800 


Ile Lys Glu Phe Leu Lys Glu Asn Asp Ser Lys Thr Leu Asn Leu Tyr 
                805                 810                 815     


Leu Phe Phe Asn Met Ile Asp Ser Lys Arg Ile Ser Glu Phe Arg Asn 
            820                 825                 830         


Glu Leu Ile Lys Tyr Lys Gln Phe Thr Lys Lys Arg Leu Asp Glu Glu 
        835                 840                 845             


Lys Glu Phe Leu Gly Ile Lys Ile Glu Leu Tyr Glu Thr Leu Ile Glu 
    850                 855                 860                 


Phe Val Ile Leu Thr Arg Glu Lys Leu Asp Thr Lys Lys Ser Glu Glu 
865                 870                 875                 880 


Thr Asp Ala Trp Leu Val Asp Lys Leu Tyr Val Lys Glu Lys Asn Glu 
                885                 890                 895     


Cys Asn Glu Tyr Glu Tyr Lys Glu Tyr Glu Glu Ile Leu Lys Leu Phe 
            900                 905                 910         


Val Asp Glu Lys Ile Leu Ile Ser Lys Glu Ala Pro Tyr Tyr Ala Thr 
        915                 920                 925             


Asn Asn Lys Thr Pro Ile Ile Leu Ser Asn Phe Glu Lys Thr Arg Lys 
    930                 935                 940                 


Tyr Gly Thr Gln Asn Leu Leu Ala Lys Ile Gln Ser Ser Tyr Lys Tyr 
945                 950                 955                 960 


Asn Glu Ile Glu Lys Gln Lys Ile Glu Asn Tyr Asn Glu Lys Lys Glu 
                965                 970                 975     


Ser Glu Lys Lys Lys Lys Ser Asn Ile Glu Lys Leu Gln Asp Leu Lys 
            980                 985                 990         


Val Glu Leu His Lys Lys Trp Glu  Gln Asn Lys Ile Thr  Glu Lys Glu 
        995                 1000                 1005             


Ile Lys  Lys Tyr Asn Asp Thr  Ile Lys Glu Ile Arg  Glu Tyr Asn 
    1010                 1015                 1020             


Tyr Leu  Lys Asn Lys Glu Glu  Leu Gln Asn Val Tyr  Leu Leu His 
    1025                 1030                 1035             


Glu Ile  Leu Ser Asp Leu Leu  Ala Arg Asn Val Ala  Phe Phe Asn 
    1040                 1045                 1050             


Lys Trp  Glu Arg Asp Phe Lys  Phe Ile Val Ile Ala  Ile Lys Gln 
    1055                 1060                 1065             


Phe Leu  Arg Glu Asn Asp Lys  Glu Lys Val Asn Glu  Phe Leu Asn 
    1070                 1075                 1080             


Pro His  Lys Ser Asp Gly Ser  Arg Asp Asn Phe Ser  Val Thr Asn 
    1085                 1090                 1095             


Tyr Arg  Ser Lys Met Lys Ser  Ile Ile Asn Asn Ile  His Glu Asn 
    1100                 1105                 1110             


Phe Met  Ser Leu Leu Phe Leu  Asn Asn Asn Leu Ala  Thr Gly Gly 
    1115                 1120                 1125             


Ile Gln  Met Gly Arg Asn Asn  Asn Phe Thr Trp Gly  Asn Leu Arg 
    1130                 1135                 1140             


Asn Tyr  Ile Ala His Phe Glu  Tyr Leu His Lys Glu  Lys Asp Thr 
    1145                 1150                 1155             


Ile Ser  Phe Ile Gly Gln Ala  Asn Leu Leu Ile Lys  Leu Phe Ser 
    1160                 1165                 1170             


Tyr Asp  Lys Lys Val Gln Asn  His Ile Ile Lys Ser  Met Lys Thr 
    1175                 1180                 1185             


Leu Leu  Glu Lys Tyr Asn Ile  Glu Ile Arg Phe Glu  Ile Ser Asn 
    1190                 1195                 1200             


Asp Ser  Glu Glu Ile Phe Glu  Tyr Lys Ile Lys Tyr  Ile Asn Ser 
    1205                 1210                 1215             


Lys Lys  Gly Lys Met Leu Gly  Lys Asn Asn Glu Phe  Glu Ile Leu 
    1220                 1225                 1230             


Glu Asn  Glu Phe Val Arg Asn  Val Lys Ala Leu Leu  Glu Tyr Ser 
    1235                 1240                 1245             


Lys 
    


<210>  84
<211>  1160
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  84

Met Lys Ile Thr Lys Ile Asp Gly Ile Ser His Lys Lys Tyr Ile Lys 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Lys Thr Asp Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Thr Ile Arg Leu Asp Thr Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Lys Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Glu Phe Phe Ser Asn Lys Val Leu Tyr Leu Lys Asp Gly Ile Leu 
65                  70                  75                  80  


Tyr Leu Lys Asp Arg Arg Glu Lys Asn Gln Leu Gln Asn Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Leu Val Leu Lys Lys Ile Leu Leu Asn Gly Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Asn Asp Phe Glu Lys Lys Leu Asp Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Leu Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Ile Lys Lys Val Glu Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Phe Tyr Asn Tyr Tyr Lys Asp Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Ile Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Asn Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Glu Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Thr Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Met 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asn Val Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asn Lys Glu Lys Leu Asn Asp Glu 
        275                 280                 285             


Asn Ile Lys Tyr Val Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Ser Phe Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asn Phe Ile 
        355                 360                 365             


Val Gly Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Thr Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Ile Lys Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Ile Ser Gly Glu Ile Asp Lys Leu Tyr Asp 
            420                 425                 430         


Asn Asn Lys Gln Asn Glu Val Lys Lys Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asn Ser Lys Lys Glu Ile Glu Asp Phe Phe Ser 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Thr Phe Lys Asn Ile Val 
                485                 490                 495     


Pro Ser Gln Ile Ser Lys Lys Met Phe His Asp Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Lys Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Asn Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Cys Ile Tyr Trp 
                565                 570                 575     


Lys Ile Pro Lys Ala Asn Asp Asn Asn Lys Thr Lys Glu Ile Thr Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ile Lys Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asn Leu Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Phe Tyr Met Ile Asp Ala Gly Asn Lys Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Ala Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Met 
    690                 695                 700                 


Tyr Ile Gly Asn Asp Glu Gln Ile Asn Thr Ser Leu Ala Gly Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Lys Ile Leu Lys Tyr Thr Glu Ser Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Ala Phe Ser Asp Gln Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Val Lys Asp Asn Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Lys Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Glu Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Lys 
        915                 920                 925             


Lys Tyr Glu Lys Ala Ile Arg Asn Ile Gln Gln Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Ser Leu Leu Leu 
945                 950                 955                 960 


Arg Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Asn Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Ser Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asp  Thr Glu Lys Ile Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Glu Leu  Lys Lys Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  Asn Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Met Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Ile Met Lys Ser  Ile Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Val Thr Phe Lys  Ile Glu Lys Asp Lys  Lys Ile Arg 
    1100                 1105                 1110             


Ile Glu  Ser Leu Lys Ser Glu  Glu Val Val His Leu  Lys Lys Leu 
    1115                 1120                 1125             


Lys Leu  Lys Asp Asn Asp Lys  Lys Lys Glu Pro Ile  Lys Thr Tyr 
    1130                 1135                 1140             


Arg Asn  Ser Lys Glu Asn Phe  Gly Ile Leu Val Cys  Ile Ile Lys 
    1145                 1150                 1155             


Lys Ile  
    1160 


<210>  85
<211>  1158
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  85

Met Lys Val Thr Lys Val Gly Gly Ile Ser His Lys Lys Tyr Thr Ser 
1               5                   10                  15      


Glu Gly Arg Leu Val Lys Ser Glu Ser Glu Glu Asn Arg Thr Asp Glu 
            20                  25                  30          


Arg Leu Ser Ala Leu Leu Asn Met Arg Leu Asp Met Tyr Ile Lys Asn 
        35                  40                  45              


Pro Ser Ser Thr Glu Thr Lys Glu Asn Lys Lys Arg Ile Gly Lys Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Met Val Tyr Leu Lys Asp Asn Thr Leu 
65                  70                  75                  80  


Ser Leu Lys Asn Gly Lys Lys Glu Asn Ile Asp Arg Glu Tyr Ser Glu 
                85                  90                  95      


Thr Asp Ile Ser Glu Tyr Asp Val Arg Asp Ser Lys Asn Phe Ala Val 
            100                 105                 110         


Leu Lys Lys Ile Tyr Leu Asn Glu Asn Val Asn Ser Glu Glu Leu Glu 
        115                 120                 125             


Val Phe Arg Lys Asp Ile Lys Lys Lys Leu Asn Lys Ile Asn Ser Leu 
    130                 135                 140                 


Lys Tyr Ser Phe Glu Lys Asn Lys Ala Asn Tyr Gln Lys Ile Asn Glu 
145                 150                 155                 160 


Asn Asn Ile Glu Lys Val Glu Gly Lys Ser Lys Arg Asn Ile Ile Tyr 
                165                 170                 175     


Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asp Ala Tyr Val Ser Asn Val 
            180                 185                 190         


Lys Glu Ala Phe Asp Lys Leu Tyr Lys Glu Glu Asp Ile Ala Lys Leu 
        195                 200                 205             


Val Leu Lys Ile Glu Asn Leu Thr Lys Leu Glu Lys Tyr Lys Ile Arg 
    210                 215                 220                 


Glu Phe Tyr His Glu Ile Ile Gly Arg Lys Asn Asp Lys Glu Asn Phe 
225                 230                 235                 240 


Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Met Lys Glu 
                245                 250                 255     


Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser Gln Val 
            260                 265                 270         


Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Glu Asn Val 
        275                 280                 285             


Lys Tyr Val Phe Cys His Phe Val Glu Ile Glu Met Ser Gln Leu Leu 
    290                 295                 300                 


Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp Lys Ile 
305                 310                 315                 320 


Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu Asn Lys 
                325                 330                 335     


Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys Tyr Asn 
            340                 345                 350         


Tyr Tyr Leu Gln Val Gly Glu Ile Ala Thr Ser Asp Phe Ile Ala Arg 
        355                 360                 365             


Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val Ser Ser 
    370                 375                 380                 


Val Ser Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn Lys Asp 
385                 390                 395                 400 


Asp Ile Thr Gly Lys Met Arg Gly Lys Thr Arg Ile Asp Ser Lys Thr 
                405                 410                 415     


Gly Glu Glu Lys Tyr Ile Pro Gly Glu Val Asp Gln Ile Tyr Tyr Glu 
            420                 425                 430         


Asn Lys Gln Asn Glu Val Lys Asn Lys Leu Lys Met Phe Tyr Gly Tyr 
        435                 440                 445             


Asp Phe Asp Met Asp Asn Lys Lys Glu Ile Glu Asp Phe Phe Ala Asn 
    450                 455                 460                 


Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe Asn 
465                 470                 475                 480 


Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Val Pro 
                485                 490                 495     


Ser Glu Ile Ser Lys Lys Ile Phe Gln Asn Glu Ile Asn Glu Lys Lys 
            500                 505                 510         


Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe Asn 
        515                 520                 525             


Phe Tyr Glu Lys Asp Val Ile Ile Lys Tyr Leu Lys Asn Thr Lys Phe 
    530                 535                 540                 


Asn Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys Leu 
545                 550                 555                 560 


Tyr Asn Lys Ile Asp Asp Leu Arg Asn Thr Leu Lys Phe Ser Trp Lys 
                565                 570                 575     


Ile Pro Lys Asp Lys Glu Glu Lys Asp Ala Gln Ile Tyr Leu Leu Lys 
            580                 585                 590         


Asn Ile Tyr Tyr Gly Glu Phe Leu Asn Lys Phe Val Lys Asn Ser Lys 
        595                 600                 605             


Asp Phe Phe Lys Ile Thr Asp Glu Val Ile Lys Ile Asn Lys Gln Arg 
    610                 615                 620                 


Asn Gln Lys Thr Gly Tyr Tyr Lys Tyr Gln Lys Phe Glu Asn Ile Glu 
625                 630                 635                 640 


Lys Thr Val Pro Val Glu Tyr Leu Ala Ile Ile Gln Ser Arg Asp Met 
                645                 650                 655     


Ile Asn Asn Gln Asp Lys Glu Glu Lys Asn Thr Tyr Ile Asp Phe Val 
            660                 665                 670         


Gln Gln Ile Phe Leu Lys Gly Phe Ile Asp Tyr Leu Asn Lys Asn Asn 
        675                 680                 685             


Leu Lys Tyr Ile Glu Asn Asn Asn Asn Asn Asp Ile Phe Ser Arg Ile 
    690                 695                 700                 


Lys Ile Lys Lys Asp Ser Lys Glu Arg Tyr Asp Lys Ile Leu Lys Asn 
705                 710                 715                 720 


Tyr Glu Lys Asn Asn Arg Asn Lys Glu Ile Pro Tyr Glu Ile Asn Glu 
                725                 730                 735     


Phe Val Arg Glu Ile Lys Leu Gly Lys Ile Leu Lys Tyr Thr Glu Arg 
            740                 745                 750         


Leu Asn Met Phe Tyr Leu Ile Leu Lys Leu Leu Asn His Lys Glu Leu 
        755                 760                 765             


Thr Asn Leu Lys Gly Ser Leu Glu Lys Tyr Gln Ser Ala Asn Lys Glu 
    770                 775                 780                 


Glu Thr Phe Ser Asp Glu Leu Glu Leu Ile Asn Leu Leu Asn Leu Asp 
785                 790                 795                 800 


Asn Asn Arg Val Thr Glu Asp Phe Glu Leu Glu Ala Asp Glu Ile Gly 
                805                 810                 815     


Lys Phe Leu Asp Phe Asn Gly Asp Lys Val Lys Asp Arg Lys Glu Leu 
            820                 825                 830         


Lys Lys Phe Asp Thr Lys Lys Ile Tyr Phe Asp Gly Glu Asn Ile Ile 
        835                 840                 845             


Lys His Arg Ala Phe Tyr Asn Ile Lys Lys Tyr Gly Met Leu Asn Leu 
    850                 855                 860                 


Leu Glu Lys Ile Ala Asp Lys Ala Lys Tyr Lys Ile Ser Ile Glu Glu 
865                 870                 875                 880 


Leu Arg Asn Tyr Ser Asn Lys Lys Asn Glu Ile Glu Lys Asn His Thr 
                885                 890                 895     


Thr Gln Glu Asn Leu His Arg Lys Tyr Ala Arg Pro Arg Lys Asp Glu 
            900                 905                 910         


Lys Phe Thr Asp Glu Asp Tyr Lys Lys Tyr Glu Lys Ala Ile Arg Asn 
        915                 920                 925             


Ile Gln Gln Tyr Thr His Leu Lys Asn Lys Val Glu Phe Asn Glu Leu 
    930                 935                 940                 


Asn Leu Leu Gln Gly Leu Leu Leu Arg Ile Leu His Arg Leu Val Gly 
945                 950                 955                 960 


Tyr Thr Ser Ile Trp Glu Arg Asp Leu Arg Phe Arg Leu Lys Gly Glu 
                965                 970                 975     


Phe Pro Glu Asn Gln Tyr Ile Glu Glu Ile Phe Asn Phe Glu Asn Lys 
            980                 985                 990         


Lys Asn Val Lys Tyr Lys Gly Gly  Gln Ile Val Glu Lys  Tyr Ile Lys 
        995                 1000                 1005             


Phe Tyr  Lys Glu Leu Tyr Gln  Asn Asp Glu Thr Lys  Ile Asn Lys 
    1010                 1015                 1020             


Tyr Ser  Ser Ala Asn Ile Lys  Val Leu Lys Gln Glu  Lys Lys Asp 
    1025                 1030                 1035             


Leu Tyr  Ile Arg Asn Tyr Ile  Ala His Phe Asn Tyr  Ile Pro His 
    1040                 1045                 1050             


Ala Glu  Ile Ser Ile Leu Glu  Val Leu Glu Asn Leu  Arg Lys Leu 
    1055                 1060                 1065             


Leu Ser  Tyr Asp Arg Lys Leu  Lys Asn Ala Val Met  Lys Ser Val 
    1070                 1075                 1080             


Val Asp  Ile Leu Lys Glu Tyr  Gly Phe Val Ala Lys  Phe Lys Ile 
    1085                 1090                 1095             


Gly Ala  Asp Lys Lys Ile Glu  Ile Gln Ser Leu Lys  Ser Glu Glu 
    1100                 1105                 1110             


Ile Val  His Leu Lys Lys Leu  Lys Leu Lys Asp Asn  Asp Lys Lys 
    1115                 1120                 1125             


Lys Glu  Pro Ile Lys Thr Tyr  Arg Asn Ser Lys Glu  Leu Cys Lys 
    1130                 1135                 1140             


Leu Val  Lys Val Met Phe Glu  Tyr Lys Tyr Gly Arg  Lys Lys Phe 
    1145                 1150                 1155             


<210>  86
<211>  1148
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  86

Met Lys Val Thr Lys Ile Asp Gly Leu Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ile Glu Asp Ala Ser Gln Lys Asn Glu Thr 
            20                  25                  30          


Leu Glu Arg Leu Glu Lys Leu Lys Glu Ile Lys Leu Gly Asn Tyr Ile 
        35                  40                  45              


Lys Asn Pro Asp Lys Thr Lys Asp Lys Asp Asn Lys Lys Arg Arg Lys 
    50                  55                  60                  


Gly Leu Lys Glu Tyr Phe Ser Glu Ile Thr Leu Arg Lys Glu Asn Glu 
65                  70                  75                  80  


Lys Tyr Val Leu Leu Lys Gly Lys Lys Leu Lys Lys Ile Asn Asn Asp 
                85                  90                  95      


Ile Lys Asp Thr Asp Ile Lys Val Lys Tyr Lys Lys Glu Glu Val Phe 
            100                 105                 110         


Asp Val Leu Lys Lys Ile Leu Lys Leu Asn Leu Leu Ala Asn Asp Val 
        115                 120                 125             


Glu Glu Lys Ile Gln Phe Asp Ser Ile Lys Leu Lys Asn Val Phe Gly 
    130                 135                 140                 


Lys Asp Phe Val Lys Lys Glu Leu Gln Ile Lys Ser Ile Glu Glu Ser 
145                 150                 155                 160 


Leu Glu Lys Asn Lys Ala Asp Tyr Arg Lys Glu Phe Ile Glu Ile Glu 
                165                 170                 175     


Asn Asp Lys Tyr Gly Asn Val Lys Gly Glu Asn Lys Lys Asn Arg Ile 
            180                 185                 190         


Tyr Glu Tyr Tyr Lys Lys Ser Glu Thr His Glu Lys Phe Arg Lys Asn 
        195                 200                 205             


Ile Ile Glu Ala Phe Glu Lys Leu Tyr Lys Lys Asp Asp Ile Glu Lys 
    210                 215                 220                 


Leu Tyr Thr Gln Ile Ile Glu Ile Ser Lys Lys Met His Leu Lys Ser 
225                 230                 235                 240 


Lys Val Arg Glu Leu Tyr Lys Asn Val Ile Ile Lys Arg Ser Cys Asp 
                245                 250                 255     


Asp Phe Ser Lys Lys Asn Lys Glu Gly Ile Ser Val Leu Tyr Ser Gln 
            260                 265                 270         


Ile Met Asn Ser Val Lys Lys Asn Glu Lys Phe Val Lys Phe Val Lys 
        275                 280                 285             


Asn Ile Glu Leu Lys Asp Leu Thr Lys Ser Gln Ile Phe Tyr Lys Tyr 
    290                 295                 300                 


Phe Leu Glu Asn Glu Glu Leu Asn Asp Glu Asn Ile Lys Asn Ile Phe 
305                 310                 315                 320 


Cys Tyr Phe Val Glu Ile Glu Val Ser Asp Leu Leu Lys Gly Asn Val 
                325                 330                 335     


Tyr Lys Val Ser Lys Ile Tyr Glu Asn Lys Ile Lys Asn Ile Phe Glu 
            340                 345                 350         


Tyr Asn Lys Leu Lys Lys Leu Val Ile Asn Lys Leu Glu Asn Lys Leu 
        355                 360                 365             


Asn Asn Tyr Val Arg Asn Cys Gly Lys Tyr Asn Tyr His Met Glu Asn 
    370                 375                 380                 


Gly Asp Ile Ala Thr Ser Asp Ile Asn Met Arg Asn Arg Gln Thr Glu 
385                 390                 395                 400 


Ala Phe Leu Arg Ser Met Ile Gly Val Ser Ser Phe Gly Tyr Phe Ser 
                405                 410                 415     


Leu Arg Asn Ile Leu Gly Val Asn Asp Asp Asp Phe Tyr Glu Ile Glu 
            420                 425                 430         


Glu Asp Leu Thr Glu Glu Glu Arg Lys Asn Glu Ser Asn Val Leu Lys 
        435                 440                 445             


Lys Ala Lys Glu Asp Ile Thr Ser Lys Ser Ile Phe Glu Lys Val Val 
    450                 455                 460                 


Asp Lys Ser Phe Glu Lys Lys Gly Ile His Ser Ile Arg Glu Asn Val 
465                 470                 475                 480 


Lys Met Phe Tyr Gly Asp Ser Phe Asp Lys Ala Asn Glu Asp Glu Leu 
                485                 490                 495     


Lys Gln Phe Phe Val Asn Met Leu Asn Ala Ile Thr Ser Ile Arg His 
            500                 505                 510         


Arg Val Val His Tyr Asn Met Asn Thr Asn Ser Glu Asn Ile Phe Asn 
        515                 520                 525             


Phe Ser Asp Ile Glu Val Ser Arg Leu Leu Lys Ser Ile Phe Glu Lys 
    530                 535                 540                 


Glu Thr Asp Lys Arg Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn 
545                 550                 555                 560 


Ser Ala Gly Val Phe Asp Tyr Trp Glu Asn Trp Lys Ile Lys Lys Tyr 
                565                 570                 575     


Leu Glu Asn Met Lys Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val 
            580                 585                 590         


Pro Ser Phe Thr Lys Leu Tyr Asn Arg Ile Asp Asn Leu Lys Gly Ser 
        595                 600                 605             


Asn Ala Leu Asn Leu Gly Tyr Ile Asn Ile Pro Lys Arg Lys Glu Ala 
    610                 615                 620                 


Arg Asp Ser Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Lys Phe 
625                 630                 635                 640 


Val Glu Glu Phe Ile Lys Asn Asn Asp Asn Phe Glu Lys Ile Phe Arg 
                645                 650                 655     


Glu Ile Ile Glu Ile Asn Lys Asn Ala Gly Thr Asn Lys Gln Thr Asn 
            660                 665                 670         


Phe Tyr Lys Leu Glu Lys Phe Glu Lys Leu Lys Ala Asn Thr Pro Thr 
        675                 680                 685             


Glu Tyr Leu Glu Lys Leu Gln Ser Leu His Lys Ile Asn Tyr Asn Arg 
    690                 695                 700                 


Glu Lys Ile Glu Glu Asp Lys Asp Ile Tyr Val Asp Phe Val Gln Lys 
705                 710                 715                 720 


Ile Phe Leu Lys Gly Phe Ile Ser Tyr Leu Gln Lys Ser Asn Ser Leu 
                725                 730                 735     


Lys Pro Leu Asn Leu Leu Asn Leu Lys Lys Asp Glu Val Ile Asn Ser 
            740                 745                 750         


Glu Lys Ser Phe Tyr Asp Glu Lys Leu Lys Gln Trp Glu Asn Asn Gly 
        755                 760                 765             


Ser Asn Leu Ser Glu Met Pro Lys Glu Ile Tyr Lys Tyr Ile Lys Glu 
    770                 775                 780                 


Ile Lys Ile Asn Lys Thr Asn Tyr Ser Asp Arg Met Ser Ile Phe Tyr 
785                 790                 795                 800 


Leu Leu Leu Lys Leu Ile Asp His Lys Glu Leu Thr Asn Leu Arg Gly 
                805                 810                 815     


Asn Leu Glu Lys Tyr Glu Ser Met Asn Lys Asn Lys Ile Tyr Ser Glu 
            820                 825                 830         


Glu Leu Asn Ile Val Asn Leu Val Ser Leu Asp Asn Asn Lys Val Arg 
        835                 840                 845             


Thr Asn Phe Ser Val Glu Ala Glu Asp Ile Gly Lys Phe Leu Lys Thr 
    850                 855                 860                 


Glu Thr Ser Ile Lys Asn Ile Asn Gln Leu Asn Asn Phe Ser Gly Ile 
865                 870                 875                 880 


Phe Ala Asp Gly Glu Asn Val Ile Lys His Arg Ser Phe Tyr Asn Ile 
                885                 890                 895     


Lys Lys Tyr Gly Ile Leu Asp Leu Leu Glu Lys Ile Val Ala Lys Ala 
            900                 905                 910         


Asp Leu Lys Ile Ala Lys Glu Glu Ile Lys Lys Tyr Glu Asn Leu Gln 
        915                 920                 925             


Lys Glu Leu Glu Lys Asn Asp Phe Tyr Lys Ile Gln Glu Lys Ile His 
    930                 935                 940                 


Arg Lys Tyr Asn Gln Lys Pro Asn Leu Ile Ser Arg Thr Glu Asn Lys 
945                 950                 955                 960 


Lys Asp Phe Asn Asp Tyr Lys Lys Ala Ile Glu Asn Ile Gln Asn Tyr 
                965                 970                 975     


Thr Gln Leu Lys Asn Lys Ile Glu Phe Asn Asp Leu Asn Leu Leu Gln 
            980                 985                 990         


Gly Leu Leu Phe Arg Ile Leu His  Arg Leu Thr Gly Tyr  Thr Ser Leu 
        995                 1000                 1005             


Trp Glu  Arg Asp Leu Gln Phe  Lys Leu Lys Gly Glu  Phe Pro Glu 
    1010                 1015                 1020             


Asp Lys  Tyr Ile Asp Glu Ile  Phe Asn Ser Asp Arg  Asn Asn Asn 
    1025                 1030                 1035             


Gln Lys  Tyr Lys Ser Gly Gly  Ile Ala Tyr Lys Tyr  Val Asp Phe 
    1040                 1045                 1050             


Leu Ile  Glu Lys Glu Glu Gly  Lys Arg Ala Gly Lys  Asn Lys Val 
    1055                 1060                 1065             


Lys Lys  Arg Ser Glu Arg Glu  Arg Ser Phe Ile Ile  Arg Asn Tyr 
    1070                 1075                 1080             


Ile Ala  His Phe Asn Tyr Ile  Pro Asp Ala Glu Lys  Ser Ile Leu 
    1085                 1090                 1095             


Glu Ile  Leu Glu Glu Leu Arg  Glu Leu Leu Lys Tyr  Asp Arg Lys 
    1100                 1105                 1110             


Leu Lys  Asn Ala Val Met Lys  Ser Ile Lys Asp Ile  Phe Lys Glu 
    1115                 1120                 1125             


Tyr Gly  Phe Ile Ile Glu Phe  Gly Ile Ser His Glu  Ser Asn Ser 
    1130                 1135                 1140             


Lys Lys  Ile Lys Val 
    1145             


<210>  87
<211>  1169
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  87

Met Gly Ser Gly Lys Tyr Arg Ile Thr Lys Ile Ala Arg Asp Trp Asp 
1               5                   10                  15      


Glu Asn Lys Lys Arg Ile Ile Leu Lys Arg Ile Val Ser Asp Gly Glu 
            20                  25                  30          


Val Lys Tyr Val Asn Glu Asn Asn Asn Val Asp Ile Asp Ile Thr Glu 
        35                  40                  45              


Thr Tyr Tyr Arg Ile Leu Ser Asn Asn Lys Ala Lys Phe Leu Gly Ser 
    50                  55                  60                  


Asn Glu Gln Phe Ile Phe Lys Val Asn Lys Met Lys Arg Asn Ile Lys 
65                  70                  75                  80  


Asn Asp Cys Val Ile Ile Lys Asp Tyr Thr Glu Glu Glu Phe Glu Lys 
                85                  90                  95      


Leu Asp Lys Lys Ile Phe Phe Ser Arg Lys Ile Lys Val Asn Asn Lys 
            100                 105                 110         


Asp Arg Glu Lys Ile Cys Arg Asn Phe Tyr Glu Asp Glu Arg Glu Ile 
        115                 120                 125             


Met Lys Lys Arg Leu Glu Glu Ala Lys Lys Phe Asn Asn Ile Ile Phe 
    130                 135                 140                 


Asn Ile Cys Asn Lys Ile Phe Lys Leu Glu Tyr Leu Asp Tyr Thr Asp 
145                 150                 155                 160 


Glu Lys Val Tyr Lys Ile Phe Gln Asn Glu Ile Lys Val Lys Asp Val 
                165                 170                 175     


Lys Asn Leu Lys Glu Ala Phe Lys Gln Gln Glu Lys Gly Leu Glu Thr 
            180                 185                 190         


Asp Lys Leu Leu Ala Ile Ser Phe Asn Lys Lys Arg Asn Asn Ile Leu 
        195                 200                 205             


Leu Glu Phe Ile Gln Gln Ile Ala Lys Gln Glu Phe Glu Asn Gln Lys 
    210                 215                 220                 


Glu Leu Glu Asn Trp Phe Ser Tyr Gly Gly Glu Lys Tyr Cys Lys Glu 
225                 230                 235                 240 


Ile Phe Lys Ile Tyr Ser Asn Met Ser Gln Lys Glu Lys Tyr Phe Lys 
                245                 250                 255     


Leu Leu Gly His Arg Asn Gln Gly Ile Ala Ser Ile Tyr Asp Glu Lys 
            260                 265                 270         


Lys Glu Thr Leu Gln Arg Arg Leu Lys Leu Gly Asp Tyr Ser Lys Tyr 
        275                 280                 285             


Asp Leu Lys Arg Tyr Tyr Gln Lys Asp Tyr Lys Glu Glu Ala Ile Lys 
    290                 295                 300                 


Glu Leu Lys Asp Lys Asn Lys Glu Gly Leu Glu Arg Glu Ile Glu Glu 
305                 310                 315                 320 


Leu Ile Lys Lys Asn Tyr Lys Ile Asp Lys Leu Cys Asp Glu Ile Ser 
                325                 330                 335     


Asn Leu Glu Phe Ser Phe Val Glu Ser Lys Lys Glu Asn Lys Asp Lys 
            340                 345                 350         


Met Ser Glu Ile Ile Val Lys Ile Lys Glu His Tyr Lys Lys Asn Val 
        355                 360                 365             


Asn Val Glu Glu Glu Leu Glu Asn Lys Glu Lys Tyr Ile Leu Ser Ile 
    370                 375                 380                 


Ile His Asn Tyr Val Lys Gly Arg Tyr Arg Lys Cys Leu Glu Leu Gln 
385                 390                 395                 400 


Gln Lys Glu Asn Val Asp Phe Glu Asn Leu Glu Lys Arg Ile Lys Glu 
                405                 410                 415     


Ile Phe Asp Ser Asn Glu Val Thr Lys Lys Leu Lys Lys Ser Ile Ile 
            420                 425                 430         


Asn Lys Val Asn Ser Tyr Lys Ile Phe Glu Met Lys Phe Gln Asn Pro 
        435                 440                 445             


Asn Val Glu Ser Ser Asp Asp Leu Glu Ile Leu Lys Ala Glu Glu Thr 
    450                 455                 460                 


Phe Leu Asn Lys Leu Ser Thr Ala Val Ser Lys Val Gly Tyr Ile Leu 
465                 470                 475                 480 


Asn Ile Leu Leu Glu Ile His Phe Arg Asn Asp Ile Leu Gln Asp Tyr 
                485                 490                 495     


Asn Gln Val Glu Lys Leu Trp Lys Ser Asp Ser Phe Gln Lys Ile Cys 
            500                 505                 510         


Ala Ile Tyr Pro Glu Ile Asn Asn Asp Glu Lys Leu Leu Lys Gly Met 
        515                 520                 525             


Ile Tyr Phe Ile Gln Gly Leu Arg Gln Gln Val Leu His Pro Lys Ile 
    530                 535                 540                 


Leu Trp Glu Lys Gln Asn Ile Tyr Asn Ala Glu Asn Ile Lys Glu Lys 
545                 550                 555                 560 


Glu Lys Ile Val Ser Val Lys Leu Gln Asn Glu Gly Glu Ala Tyr Asn 
                565                 570                 575     


Lys Lys Gly Ile Gln Asn Tyr Phe Glu Asn Val Leu Lys Lys Ile Pro 
            580                 585                 590         


Asp Tyr Phe Ile Glu Lys Tyr Glu Ser Asn Asn Val Phe Asn Ile Tyr 
        595                 600                 605             


Arg Asn Ser Val Asp Lys Ile Met Glu Val Val Lys Asn Phe Asn Phe 
    610                 615                 620                 


Lys Glu Asn Asn Thr Ile Asp Tyr Leu Phe Pro Lys Phe His Lys Ile 
625                 630                 635                 640 


Tyr Lys Arg Met Cys Lys Ser Glu Asn Ile Asp Asp Arg Gln Asn Gly 
                645                 650                 655     


Ala Arg Lys Tyr Leu Leu Gln Thr Ile Tyr Tyr Tyr Tyr Phe Gln Tyr 
            660                 665                 670         


Glu Ile Glu Asn Asp Lys Asn Asn Met Ser Lys Tyr Leu Asn Leu Tyr 
        675                 680                 685             


Arg Asn Lys Ile Lys Val Lys Lys Ile Ser Tyr Ser Tyr Ile Ile Asp 
    690                 695                 700                 


Asn Lys Ala Val Asn Asn Lys Asn Ile Glu Ile Leu Tyr Arg Asn Ile 
705                 710                 715                 720 


Gln Arg Glu Gly Met Leu Asn Asn Arg Leu Leu Gln Met Asn Asn Glu 
                725                 730                 735     


Trp Ile Glu Phe Ile Val Val Gln Phe Ser Glu Phe Leu Thr Lys Lys 
            740                 745                 750         


Lys Leu Asn Trp Ile Leu Asp Asp Leu Ser Glu Tyr Lys Lys Lys Glu 
        755                 760                 765             


Lys Leu Asp Glu Asn Asp Lys Asn Glu Leu Leu Lys Ile Phe Lys Gln 
    770                 775                 780                 


Lys Met Asn Lys Asn Ile Thr Tyr Ser Asn Asp Ser Tyr Ala Phe Ile 
785                 790                 795                 800 


Ser Leu Ala Gln Phe Leu Asp Leu Lys Glu Ile Ser Asn Leu Ile His 
                805                 810                 815     


Asp Ile Lys Lys Phe Val Gln Phe Arg Glu Lys Asn Ile Leu Lys Tyr 
            820                 825                 830         


Asn Pro Glu Lys Asn Lys Ile Tyr Ile Glu Glu Leu Arg Lys Ile Leu 
        835                 840                 845             


Tyr Ile Leu Lys Val Met Leu Glu His Lys Glu Arg Val Ile Gln Lys 
    850                 855                 860                 


His Tyr Leu Gly Ser Tyr Asp Glu Asp Ile Ser Ile Met Tyr Gly Lys 
865                 870                 875                 880 


Asp Ile Glu Lys Lys Asp Ile Lys Asp Ile Glu Ile Lys Ile Lys Asn 
                885                 890                 895     


Lys Asn Gln Glu Val Ile Asn Gln Pro Leu Tyr Lys Ser Gly Asn Asp 
            900                 905                 910         


Glu Asn Ser Ser Trp Ile Ile Leu Tyr Gly Ile Glu Gln Ala Lys Arg 
        915                 920                 925             


Asn Gly Thr Phe Lys Phe Phe Glu Gly Phe Phe Asn Leu Asn Asp Asp 
    930                 935                 940                 


Ile Lys Leu Cys Lys Glu Asp Ile Glu Lys Tyr Glu Lys Leu Tyr Asn 
945                 950                 955                 960 


Glu Lys Glu Glu Asn Gln Lys Lys Val Asp Glu Tyr Ile Ser Lys Leu 
                965                 970                 975     


Asn Asn Asp Ile Glu Lys Ile Asn Asn Asp Ile Asn Ile Glu Lys Thr 
            980                 985                 990         


Asn Asp Asn Lys Gln Leu Phe Tyr  Tyr Tyr Lys Asn Met  Ile Tyr Gly 
        995                 1000                 1005             


Asp Gly  Leu Lys Lys Gly Tyr  Asp Phe Ile Asn Asp  Ile Tyr Ser 
    1010                 1015                 1020             


His Tyr  Leu Ser Trp Ala Tyr  Arg Ile Glu Arg Asp  Cys Lys Ile 
    1025                 1030                 1035             


Tyr Lys  Ile Lys Glu Tyr Glu  Asn Lys Lys Asn Phe  Asn Glu Tyr 
    1040                 1045                 1050             


Lys Phe  Lys Glu Tyr Lys Ser  Ile Lys Tyr Phe Arg  Asn Glu Ile 
    1055                 1060                 1065             


Ala His  Phe Asn Tyr Phe Gln  Lys Thr Asn Lys Ser  Leu Leu Glu 
    1070                 1075                 1080             


Leu Leu  Asn Asn Phe Tyr Asp  Ile Phe Asp Tyr Asn  Leu Lys Tyr 
    1085                 1090                 1095             


Gln Arg  Asp Val Gln Lys Val  Ile Asn Asn Ile Phe  Glu Lys Tyr 
    1100                 1105                 1110             


Gln Val  Ile Arg Glu Asp Gly  Gly Pro Val Ile Phe  Tyr Cys Lys 
    1115                 1120                 1125             


Ile Asp  Lys Lys Leu Lys Leu  Ser Glu Asn Ile Ile  Pro Lys Lys 
    1130                 1135                 1140             


His Leu  Lys Cys Ser Lys Ile  Lys Leu Ile His Glu  Lys Tyr Val 
    1145                 1150                 1155             


Glu Phe  Phe Arg Lys Leu Phe  Glu Tyr Lys Lys 
    1160                 1165                 


<210>  88
<211>  1149
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  88

Met Gly Ala Gly Lys Tyr Arg Ile Thr Lys Ile Pro Arg Asn Trp Lys 
1               5                   10                  15      


Glu Asn Glu Lys Lys Val Ile Leu Lys Arg Val Val Asn Asn Gly Glu 
            20                  25                  30          


Val Lys Tyr Ile Asn Glu Asn Asp Asn Val Asp Val Asp Ile Thr Glu 
        35                  40                  45              


Thr Tyr Tyr Gly Ile Leu Ser Asn Asn Lys Ala Lys Phe Leu Gly Ser 
    50                  55                  60                  


Asn Glu Gln Phe Ile Phe Lys Val Asn Lys Met Lys Arg Asn Ile Glu 
65                  70                  75                  80  


Asn Gly Cys Val Ile Ile Lys Asn Tyr Thr Glu Glu Glu Tyr Glu Lys 
                85                  90                  95      


Phe Asp Lys Lys Ile Phe Ser Lys Arg Arg Ile Lys Val Thr Asn Lys 
            100                 105                 110         


Asn Ile Glu Lys Ile Cys Arg Asn Phe Tyr Glu Asp Glu Glu Glu Ile 
        115                 120                 125             


Met Lys Lys Arg Phe Glu Glu Ala Lys Asn Phe Asn Asn Ile Ile Phe 
    130                 135                 140                 


Lys Ile Cys Ser Glu Ile Phe Glu Leu Glu Tyr Ile Asn Tyr Thr Asp 
145                 150                 155                 160 


Glu Lys Leu Tyr Lys Ile Phe Gln Asn Lys Ile Lys Val Lys Asp Val 
                165                 170                 175     


Lys Asn Leu Lys Glu Ala Phe Lys Gln Gln Glu Lys Gly Leu Glu Thr 
            180                 185                 190         


Asp Lys Leu Leu Ala Ile Ser Phe Asn Lys Lys Arg Asn Asn Ala Leu 
        195                 200                 205             


Leu Glu Phe Ile Gln Gln Ile Val Lys Gln Lys Phe Glu Asn Glu Lys 
    210                 215                 220                 


Glu Leu Glu Asn Trp Phe Ser His Ser Gly Glu Lys Tyr Cys Lys Glu 
225                 230                 235                 240 


Ile Phe Lys Ile Tyr Ser Asn Met Ser Gln Lys Glu Lys Tyr Ser Lys 
                245                 250                 255     


Leu Leu Gly His Arg Asn Lys Ser Phe Ala Ser Ile Ser Glu Lys Lys 
            260                 265                 270         


Glu Thr Leu Gln Arg Arg Leu Lys Leu Gly Asn Tyr Ser Asn Tyr Asn 
        275                 280                 285             


Leu Arg Lys Tyr Tyr Gln Lys Asp Tyr Lys Glu Glu Ala Ile Lys Glu 
    290                 295                 300                 


Leu Lys Asp Lys Ser Lys Glu Lys Leu Glu Lys Glu Ile Glu Glu Ile 
305                 310                 315                 320 


Ile Lys Glu Asn Tyr Lys Ile Asp Lys Leu Cys Glu Glu Ile Ser Asn 
                325                 330                 335     


Leu Glu Phe Ser Phe Ala Glu Ser Lys Lys Glu Asn Lys Asp Lys Met 
            340                 345                 350         


Ser Glu Ile Ile Val Lys Ile Lys Glu His Tyr Lys Asn Asn Val Asn 
        355                 360                 365             


Val Glu Glu Glu Leu Glu Asn Lys Glu Lys Tyr Ile Leu Ser Met Ile 
    370                 375                 380                 


His Asn Tyr Ile Lys Gly Arg Tyr Arg Lys Cys Leu Glu Leu Gln Gln 
385                 390                 395                 400 


Lys Glu Asn Val Asp Phe Glu Asn Leu Glu Lys Arg Ile Lys Glu Ile 
                405                 410                 415     


Phe Asp Ser Asn Glu Val Thr Lys Lys Leu Lys Lys Leu Ile Leu Asn 
            420                 425                 430         


Lys Val Asn Asn Tyr Lys Ile Phe Glu Thr Lys Phe Gln Asn Pro Asn 
        435                 440                 445             


Ile Glu Ser Ser Asp Asp Leu Glu Ile Leu Lys Ala Glu Glu Thr Phe 
    450                 455                 460                 


Leu Asn Lys Leu Ser Thr Ala Val Ser Lys Val Gly Tyr Thr Leu Asn 
465                 470                 475                 480 


Thr Leu Leu Glu Val Ser Pro Glu Lys Asp Ile Leu Glu Lys Tyr Glu 
                485                 490                 495     


Glu Val Glu Lys Leu Cys Thr Ser Asn Ser Ile Lys Asn Leu Cys Thr 
            500                 505                 510         


Val Tyr Ser Glu Ile Asn Asn Asn Glu Lys Leu Leu Lys Gly Met Ile 
        515                 520                 525             


Tyr Phe Ile Gln Gly Leu Arg Gln Gln Val Leu His Pro Lys Ile Leu 
    530                 535                 540                 


Trp Glu Lys Asn Val His Lys Ala Glu Lys Val Lys Glu Lys Glu Lys 
545                 550                 555                 560 


Ile Val Ile Arg Phe Gln Asn Glu Gly Lys Ala Tyr Asn Lys Lys Arg 
                565                 570                 575     


Ile Glu Glu Tyr Phe Glu Asn Ile Leu Glu Lys Ile Pro Asp Tyr Phe 
            580                 585                 590         


Ile Glu Lys Tyr Glu Ser Asn Asn Val Phe Asn Ile Tyr Arg Asn Phe 
        595                 600                 605             


Ile Asp Glu Ile Phe Glu Ile Ile Asp Lys Phe Asp Phe Lys Glu Ser 
    610                 615                 620                 


Asn Ser Ile Ser Tyr Leu Phe Pro Lys Phe His Lys Ile Tyr Lys Arg 
625                 630                 635                 640 


Ile Cys Lys Ser Glu Asn Ile Asn Asp Arg Gln Asn Gly Ala Arg Lys 
                645                 650                 655     


Tyr Leu Leu Gln Thr Ile Tyr Tyr Tyr Tyr Phe Gln Tyr Glu Ile Glu 
            660                 665                 670         


Asn Asn Lys Asn Asp Ile Phe Lys Tyr Leu Asn Leu Tyr Lys Ser Lys 
        675                 680                 685             


Ile Lys Ala Lys Lys Ile Ser Tyr Ser His Ile Ile Asp Asn Lys Asp 
    690                 695                 700                 


Val Asn Asn Lys Asn Ile Glu Ile Leu Tyr Arg Asn Ile Gln Arg Glu 
705                 710                 715                 720 


Gly Met Leu Asn Asn Arg Leu Leu Gln Met Asn Asn Glu Trp Ile Glu 
                725                 730                 735     


Phe Ile Met Ile Gln Phe Ile Glu Phe Ile Ser Thr Lys Lys Leu Asn 
            740                 745                 750         


Trp Ile Leu Asp Asp Leu Ser Glu Tyr Arg Lys Lys Glu Lys Leu Asp 
        755                 760                 765             


Glu Lys Asn Lys Asn Lys Leu Leu Glu Asn Leu Lys Gln Lys Met Asn 
    770                 775                 780                 


Lys Asn Ile Thr Tyr Ser Asn Asp Ser Tyr Val Phe Ile Ser Leu Ala 
785                 790                 795                 800 


Gln Phe Leu Asp Leu Lys Glu Ile Ser Asn Leu Ile His Asp Ile Lys 
                805                 810                 815     


Lys Phe Val Gln Phe Arg Glu Lys Asn Ile Ser Lys Tyr Lys Pro Glu 
            820                 825                 830         


Lys Asn Lys Val Tyr Ile Glu Glu Leu Arg Lys Ile Ser Tyr Ile Leu 
        835                 840                 845             


Lys Val Met Leu Glu His Lys Glu Arg Val Ile Gln Lys His Tyr Leu 
    850                 855                 860                 


Glu Ser Tyr Asp Glu Gly Ile Ser Ile Met Tyr Gly Lys Asp Ile Glu 
865                 870                 875                 880 


Lys Lys Gly Ile Lys Asp Ile Lys Ile Lys Ile Lys Asn Glu Asn Gln 
                885                 890                 895     


Glu Val Ile Asn Gln Pro Leu Tyr Lys Ser Gly Asn Asp Glu Asn Ser 
            900                 905                 910         


Ser Trp Ile Val Leu Tyr Gly Ile Glu Gln Ala Lys Arg Asn Gly Thr 
        915                 920                 925             


Phe Lys Phe Phe Lys Glu Phe Phe Asn Thr Asn Glu Asp Ile Lys Leu 
    930                 935                 940                 


Cys Lys Glu Asp Ile Gln Lys Tyr Glu His Leu Tyr Asn Glu Lys Glu 
945                 950                 955                 960 


Glu Asn Gln Arg Lys Val Asp Glu Tyr Ile Ser Ser Glu Glu Asn Asn 
                965                 970                 975     


Asn Ile Glu Glu Ile Lys Glu Ile Asn Asn Asn Lys Lys Gln Leu Phe 
            980                 985                 990         


Tyr Tyr Tyr Lys Asn Met Ile Asn  Gly Asp Gly Leu Lys  Lys Gly Tyr 
        995                 1000                 1005             


Asp Phe  Ile Asn Asp Ile Tyr  Ser His Cys Leu Ser  Trp Ala Tyr 
    1010                 1015                 1020             


Arg Ile  Glu Arg Asp Cys Ser  Ile Tyr Lys Val Glu  Ala Tyr Asn 
    1025                 1030                 1035             


Gly Lys  Ile Lys Asn Phe Arg  Asn Glu Ile Ala His  Phe Asn Tyr 
    1040                 1045                 1050             


Phe Gln  Lys Thr Asp Lys Ser  Leu Leu Asp Leu Leu  Asn Asp Phe 
    1055                 1060                 1065             


Tyr Asn  Ile Phe Asp Tyr Asn  Leu Lys Tyr Gln Arg  Asp Val Gln 
    1070                 1075                 1080             


Lys Val  Ile Asn Asn Ile Phe  Glu Lys Tyr Gln Val  Val Arg Glu 
    1085                 1090                 1095             


Asp Gly  Gly Pro Val Ile Phe  Tyr Cys Lys Val Asp  Lys Lys Leu 
    1100                 1105                 1110             


Lys Leu  Ser Glu Asn Leu Val  Pro Lys Lys His Ser  Lys Tyr Pro 
    1115                 1120                 1125             


Glu Ile  Glu Leu Val His Lys  Lys Tyr Val Ile Phe  Phe Lys Lys 
    1130                 1135                 1140             


Leu Phe  Glu His Lys Lys 
    1145                 


<210>  89
<211>  1339
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  89

Met Lys Ile Ile Arg Pro Tyr Gly Arg Ser Val Ile Gln Glu Lys Asp 
1               5                   10                  15      


Leu Arg Gln Arg Lys Val Leu Glu Asn Lys Thr Gly Gln Val Ala Ala 
            20                  25                  30          


Val Arg Asp Leu Leu Glu Ser Asp Gly Lys Ala Val Leu Ala Gln Trp 
        35                  40                  45              


Val Ser Ala Met Asp Lys Ile Ile Ala Lys Pro Leu Asn Lys Lys Asp 
    50                  55                  60                  


Leu Ala Ala Phe Ile Ser Gly Val Asn Asn Asn Lys Lys Ile Glu Asn 
65                  70                  75                  80  


Lys Glu Arg Ile Glu Asn Asn Asn Arg Leu Ala Leu Asn Arg Leu Ala 
                85                  90                  95      


Leu Glu Lys Arg Lys Leu Leu Gly Glu Ala Ile Trp Ala His Val Ser 
            100                 105                 110         


Asp Lys Thr Lys Pro His Cys Leu Glu Lys Pro Glu Asp Gln Glu Lys 
        115                 120                 125             


Trp Trp Arg Ala Lys Tyr Glu Glu Ala Tyr Ala Met Ser Asp Lys Met 
    130                 135                 140                 


His Arg Gly Phe Pro Lys Gly Arg Trp Tyr Lys Ile Phe Ala Gly Ile 
145                 150                 155                 160 


Glu Glu Pro Glu His Ile Asp Glu Val Gln Ala Ser Glu Ile Ala Glu 
                165                 170                 175     


Lys Ile Tyr Arg His Phe Tyr Glu Asn Ala Leu Ala Ser Gly Ser Glu 
            180                 185                 190         


Lys Ala Gly Lys Glu Lys Tyr Lys Gly Lys Gly Phe Leu Pro His Arg 
        195                 200                 205             


Ile Ala Phe Ile Gly Lys Asn Thr Leu Thr His Ala Tyr Glu Asn Tyr 
    210                 215                 220                 


Gly Lys Ser Pro Asp Arg Leu Asp Leu Thr Ala Thr Glu Ala Thr Met 
225                 230                 235                 240 


Ala Cys Tyr Lys Tyr Met Gln Lys Gly Gly Asp Ile Ala Gln Arg Ile 
                245                 250                 255     


Arg Arg Lys Ile Leu Ala Gln Phe Leu Glu Thr Thr Arg Lys Glu Asp 
            260                 265                 270         


Lys Ile Lys Glu Ser Val Tyr Ile Ile Ala Val Leu Glu Leu Lys Glu 
        275                 280                 285             


Lys Trp Lys Glu Ile Phe Ala Ala Gly Val Lys Asn Ile Ala Thr Ala 
    290                 295                 300                 


Arg Lys Thr Asp Glu Ala Leu Phe Lys Leu His Gln Thr Val Lys Glu 
305                 310                 315                 320 


Thr Tyr Lys Ile Leu Leu Lys Gly Arg Ser Leu Phe Pro Asp Lys Leu 
                325                 330                 335     


Lys Asp Lys Leu Pro Lys Asp Lys Lys Glu Ala Asp Lys Ser Arg Asn 
            340                 345                 350         


Lys Gln Ile His Asp Lys Leu Ala Glu Ile Leu Pro Arg Asp Met Lys 
        355                 360                 365             


Glu Leu Leu Gln Leu Ile Gln Tyr Lys Ser Cys Asn Arg Asp Ile Gly 
    370                 375                 380                 


His Leu Ile Arg Leu Gly Lys Ile Ile His Tyr Ser Ser Arg Asn Leu 
385                 390                 395                 400 


Thr Ser Gln Glu Gln Leu Phe Ala Ala Glu Val Glu Asn Ser Asp Tyr 
                405                 410                 415     


Trp Thr Ser Gln Gly Gln Thr Ile Ile Lys Gln Asn Glu Ala Phe Val 
            420                 425                 430         


Arg Ile Trp Arg Arg Leu Leu Ala Phe Ala Gly Arg Asn Val Ala Asp 
        435                 440                 445             


Trp Ile Ala Pro Asn Asn Asp Gly Leu Lys Asp Val Leu Gly Gly Thr 
    450                 455                 460                 


Gly Ser Cys Lys Ala Ala Leu Lys Tyr Phe Glu Glu His Tyr Glu Gly 
465                 470                 475                 480 


Asn Asp Glu Glu Gly Lys Lys Tyr Thr Ala Gly Phe Asp Glu Lys Tyr 
                485                 490                 495     


Asn Val Leu Phe Ala Asp Asp Asp Gly Leu Phe Phe Asn Lys Gly Thr 
            500                 505                 510         


Lys Thr Leu Asp Ala Leu Asn Gly Lys Gly Gly Lys Arg Pro Ile Leu 
        515                 520                 525             


Glu Phe Ile Ile Gly Ala Leu Thr Asp Leu Arg Asn Ala Ala Phe His 
    530                 535                 540                 


Phe Lys Gly Met Glu His Phe Val Glu Gln Phe Gly Lys Ala Asp Trp 
545                 550                 555                 560 


Val Ser Gly Cys Glu Arg Val Gly Glu Glu Gln Thr Gln Glu Pro His 
                565                 570                 575     


Glu Ala Gln Ala Lys Ile Val Pro Phe Leu Glu Asn Tyr Tyr His Lys 
            580                 585                 590         


Ala Cys Glu Ala Tyr Arg Met Arg Leu Leu His Ile Leu Glu Ser Ile 
        595                 600                 605             


Asn Val His Lys Phe Leu Asn Tyr Glu Gln Ile Lys Asn Phe Leu Ser 
    610                 615                 620                 


Glu Ile Thr Ala Ala Glu Ala Ser Pro Leu Pro Leu Pro Arg Phe Gln 
625                 630                 635                 640 


Lys Leu Leu Glu Arg Ser Asp Cys Ala Trp Ala Lys Ile Gly Lys Pro 
                645                 650                 655     


Leu Leu Leu Pro Pro Tyr Thr Lys Ala Arg Asp Arg Ala Gly Asp Gly 
            660                 665                 670         


Asp Lys Asp Leu Ala Lys Asn Cys Gln Tyr Asn Leu Ala His Met Leu 
        675                 680                 685             


Tyr Asp Lys Leu Phe Arg Ala Trp Leu Glu Asn Leu Pro Ala Glu Lys 
    690                 695                 700                 


Leu Gln Asp Phe Ile Lys Arg Ala Ile Glu Arg Thr Thr Glu Ala Ala 
705                 710                 715                 720 


Arg Lys Ile Asn Gly Gly Lys Thr Asp Lys Glu Leu Ile Leu Ala Arg 
                725                 730                 735     


Ala Gly Lys Leu Ser Ala Ile Gln Lys Asn Glu Arg Val Gln Trp Phe 
            740                 745                 750         


Phe Ala Gly Leu Val Ala Asp Ser Ser Thr Glu Gly Arg Val Gln Lys 
        755                 760                 765             


Asp Asn Tyr Lys His Asp Ala Asp Ala Ala Arg Glu Lys Ala Glu Tyr 
    770                 775                 780                 


Ile Glu Glu Phe Lys Gln Asp Val Val Ala Leu Ala Phe Ala Asp Tyr 
785                 790                 795                 800 


Leu Arg Glu Lys Gln Phe Ser Phe Ile Leu Asp Ile Lys Asp Val Arg 
                805                 810                 815     


Tyr Arg Asp Lys Asn Phe Pro Met Glu Thr Leu Lys Lys Thr Leu Arg 
            820                 825                 830         


Glu Glu Gly Thr Thr Glu Thr Glu Lys Thr Glu Gln Asn Gly Glu Lys 
        835                 840                 845             


Ala Asp Trp Ile Cys Ala Lys Leu Tyr Phe Leu Leu His Leu Met Pro 
    850                 855                 860                 


Val Glu Glu Val Ser Ser Leu Arg Gln Gln Ile Arg Lys Trp Glu Ile 
865                 870                 875                 880 


Val Val Asp Lys Pro Glu Val Thr Ala Ala Thr Lys Glu Ala Glu Ser 
                885                 890                 895     


Glu Asp Val Ile Glu Gly Ala Gln Glu Arg Glu Gln Lys Thr Lys Glu 
            900                 905                 910         


Arg Gln Glu Lys Ala Leu Thr Gln Pro Ile Leu Gln Ala Leu Asp Leu 
        915                 920                 925             


Tyr Ile Phe Met His Asp Ala Gln Tyr Val Gly Glu Glu Ile Glu Ala 
    930                 935                 940                 


Val Thr Ala Asp Trp Glu Glu Ile Phe Phe Glu His Gly Lys Gly Ala 
945                 950                 955                 960 


Val Asn Lys Ile Phe Pro Ala Gln Glu Arg Gln Lys Asp Leu Gln Ala 
                965                 970                 975     


Phe Arg Asp Leu Arg Glu Met Arg Arg Phe Gly Asn Thr Val Leu Asn 
            980                 985                 990         


Asp Ile Tyr Ala Arg Lys Lys Ile  Ser Ser Glu Lys Ile  Glu Gln Trp 
        995                 1000                 1005             


Arg Glu  Gln Lys Glu Lys Val  Glu Gly Lys Asn Gly  Leu Gln Thr 
    1010                 1015                 1020             


Glu Leu  Gln Thr Leu His Glu  Thr Trp Val Lys Asn  Arg Lys Asn 
    1025                 1030                 1035             


Pro Glu  Trp Gln Arg Lys Gly  Lys Asp Gly Gln Glu  Gly Glu Lys 
    1040                 1045                 1050             


Tyr Lys  Glu Tyr Arg Glu Lys  Leu Glu Ile Val Ala  Ala Tyr Arg 
    1055                 1060                 1065             


Ile Leu  Ala Gly Glu Val Lys  Leu Gln Asn His Val  Arg Leu Tyr 
    1070                 1075                 1080             


Arg Leu  Leu Met Ala Val Leu  Gly Arg Leu Val Asp  Phe Ser Gly 
    1085                 1090                 1095             


Leu Phe  Glu Arg Asp Leu Tyr  Phe Thr Leu Leu Ala  Leu Cys Tyr 
    1100                 1105                 1110             


Gln Asn  Asp Val Lys Asn Ile  Lys Ala Ile Phe Glu  Asp Asn Glu 
    1115                 1120                 1125             


Asp Ser  Gly Ala Pro Ile Glu  Lys Lys Glu Asp Gly  Glu Asn Leu 
    1130                 1135                 1140             


Leu Gln  Asp Gly Gln Val Phe  Lys Ala Leu Asp Gln  Leu Lys Gly 
    1145                 1150                 1155             


Asp Tyr  Ala Pro Ile Lys Lys  Glu Leu Val Lys Phe  Phe Gly Asp 
    1160                 1165                 1170             


Val Phe  Arg Glu Glu Lys Gly  Thr Ser Arg Asn Ile  Arg Asn Arg 
    1175                 1180                 1185             


Phe Ala  His Leu Lys Met Leu  Ser Leu Pro Glu Lys  Glu Glu Ile 
    1190                 1195                 1200             


Ser Trp  Thr Gln Gly Val Gln  Ile Asn Leu Thr Gln  Glu Val Asn 
    1205                 1210                 1215             


Asn Thr  Arg Gln Leu Met Ala  Tyr Asp Arg Lys Leu  Lys Asn Ala 
    1220                 1225                 1230             


Val Ala  Lys Ser Leu Ile Asp  Leu Leu Asp Arg Glu  Gly Leu Lys 
    1235                 1240                 1245             


Leu Ser  Trp Gln Met Ser Ile  Glu Ser Val Pro Glu  Ala Ala Ala 
    1250                 1255                 1260             


Lys Ser  Asp Lys Ser Ala Pro  Leu Lys Asp Lys Lys  Val Asn His 
    1265                 1270                 1275             


Asn Leu  Cys Asn Pro His Val  Glu Thr Lys Trp Ile  Pro His Leu 
    1280                 1285                 1290             


Gly Ser  Lys Leu Leu Asp Lys  Lys Asp Lys Asp Gly  Lys Pro Val 
    1295                 1300                 1305             


Ile Gly  Lys Asn Gly Lys Pro  Val Lys Glu Ala Ile  Thr Glu Pro 
    1310                 1315                 1320             


Arg His  Gly Asp Ile Tyr Val  Thr Met Val Lys Ser  Leu Phe Gly 
    1325                 1330                 1335             


Gly 
    


<210>  90
<211>  1451
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  90

Met Lys Ile Val Arg Gly Tyr Gly Arg Ser Ile Val Gly Lys Phe Ala 
1               5                   10                  15      


Asp Gly Glu Gly Ala Ala Glu Glu Asp Leu Lys Ile Arg Lys Leu His 
            20                  25                  30          


Thr Thr Lys Gly Asp Glu Asp Leu Ser Phe Thr Ala Phe Ala Gly Thr 
        35                  40                  45              


Glu Gly Glu Phe Ile Leu Ala Val Trp Ile Ser Val Ile Asp Lys Ile 
    50                  55                  60                  


Ile Ala Lys Ala Thr Lys Asp Glu Lys Ala Gln Ala Asp Lys Asn Ala 
65                  70                  75                  80  


Trp Ala Glu Glu Leu Arg Gln Lys Ile Gly Ala Ala Ala Trp Gln Lys 
                85                  90                  95      


Ile Leu Arg Ala Asn Arg Leu Glu Leu Ala Lys Met Trp Asn Trp Lys 
            100                 105                 110         


Ile Asn Ala Lys Ala Ser Gly Lys Gln Gly Asn Asn Phe Pro Gln Gly 
        115                 120                 125             


Asn Trp Tyr Pro Ala Phe Leu Gly Asn Ala Ala Pro Glu Arg Leu Ser 
    130                 135                 140                 


Asp Glu Gln Ile Thr Glu Leu Val His Asp Ile Asp Thr His Ile His 
145                 150                 155                 160 


Lys Ala Met Arg Gln Ile Arg Gly Asp Glu Arg Lys Gly Lys Ser Arg 
                165                 170                 175     


Pro His Ser Glu Gly Leu Leu Ala Asp Ile Val Ala Ala Val Gly Gln 
            180                 185                 190         


Asn Thr Leu Lys Val Ala Tyr Glu Lys Gln Phe Pro Glu Asp Lys Lys 
        195                 200                 205             


Arg Asp Cys Ala Phe Ser Glu Glu Glu Trp Gln Asp Tyr Arg Asp Ala 
    210                 215                 220                 


Ala Asn Lys Ala Val Gly Gly Asp Phe Val Ala Gly Leu Lys Lys Ala 
225                 230                 235                 240 


Val Leu Asp Lys Glu Asn Lys Asp Lys Pro Tyr His Lys Ala Ile Asp 
                245                 250                 255     


Tyr Leu Lys Asn Thr Val Trp Pro Lys Val Phe Cys Asp Glu Ser Gly 
            260                 265                 270         


Ala Val Leu Gly Arg Lys Asn Ala Thr Glu Gln Met Pro Lys Pro Leu 
        275                 280                 285             


Thr Val His Asp Ala Ile Thr Ala Tyr Tyr Lys Lys Leu Leu Lys Asp 
    290                 295                 300                 


Arg Gly Ser Ile Ala Gly Tyr Lys Val Arg Glu Lys Gly Glu Ala Tyr 
305                 310                 315                 320 


Gln Lys Ala Thr Ser Ile Lys Arg Gln Gly Glu Lys Ala Pro Ala Lys 
                325                 330                 335     


Leu Glu Gln Leu Leu Pro Ala Ser Val Asn Lys Leu Lys Trp Ile Leu 
            340                 345                 350         


Cys Lys Gln His Lys Asn Arg Asp Val Asn His Tyr Ile Arg Leu Gly 
        355                 360                 365             


Lys Val Leu His Tyr Thr Ala Ser Gln Phe Ser Asn Glu Asn Gln Asp 
    370                 375                 380                 


Ser Ala Ala Tyr Ile Ile Gly Asn Trp Asp Arg Ala Val Ala Ala Leu 
385                 390                 395                 400 


Pro Thr Ser Pro Tyr Trp Thr Ser Glu Gly Gln Thr Gln Ile Lys Gln 
                405                 410                 415     


Asn Glu Ala Phe Ile Arg Val Trp Arg Arg Val Leu Ala Phe Ala Val 
            420                 425                 430         


His Ser Leu Lys Asn Trp Ala Asp Pro Asp Asn Thr Val Thr Gly Asp 
        435                 440                 445             


Pro Thr Ile Thr Ala Thr Trp Thr Ala Ile Lys Lys Ala Tyr Gly Trp 
    450                 455                 460                 


Val Asp Lys Gly Glu Asp Lys Asn Glu Asp Lys Ala Lys Ala Tyr Phe 
465                 470                 475                 480 


Glu Gly Ala Phe Ile Glu Arg Tyr Glu Leu Leu Phe Gly Asn Thr Arg 
                485                 490                 495     


Pro Lys Glu Glu Lys Ser Asp Glu Lys Glu Ile Glu Ile Lys Lys Ile 
            500                 505                 510         


Ser Gln Gln Asp Lys Gln Val Ile Leu Asp Arg Leu Arg Trp His Ile 
        515                 520                 525             


Gly Asn Leu Arg Arg Ala Gly Phe His Phe Lys Gly Met Glu Thr Phe 
    530                 535                 540                 


Ile Glu Ser Leu Glu Asn Gln Asp Pro Lys Lys Pro Glu Lys Glu Val 
545                 550                 555                 560 


Ile Lys Leu Pro Lys His Met Arg Asp Phe Tyr Lys Ala Asp Arg Lys 
                565                 570                 575     


Thr Tyr Arg Ala Lys Pro Leu Lys Ile Met Gln Gly Ala Gln Phe Glu 
            580                 585                 590         


Arg Phe Phe Thr Lys Glu Gln Ile Glu Glu Met Leu Thr Ala Ala Gln 
        595                 600                 605             


Glu Trp Asp Ala Val Ser Val Thr Ala Pro Lys Gly Asp Asp Gly Gln 
    610                 615                 620                 


Gln Leu Pro Leu Pro Thr Leu Arg Arg Leu Leu Gly Arg Val Lys Lys 
625                 630                 635                 640 


Thr Trp Ser Glu Asp Gly Gln Asp Asn Ile Ala Leu Pro Pro Tyr Asp 
                645                 650                 655     


Ser Ala Ala Lys Lys Asn Glu Lys Ala Asp Glu Glu Glu Glu Ser Glu 
            660                 665                 670         


Lys Arg Ala Lys Lys Thr Glu Ser Ala Glu Asp Lys Lys Glu Lys Ala 
        675                 680                 685             


Arg His Ala Gln Tyr Ile Ala Ile Lys Gln Leu Tyr Glu Leu Pro Phe 
    690                 695                 700                 


Arg Ala Trp Leu Ala Glu Asp Leu Ser Pro Asp Thr Val Asn Thr Tyr 
705                 710                 715                 720 


Ile Gly Lys Ala Val Glu Arg Ala Thr Ala Ala Ala Gln Glu Asn Glu 
                725                 730                 735     


Thr Asp Glu Glu Val Lys Ser Cys Ile Val Ala Arg Ala Ala Ser Leu 
            740                 745                 750         


Pro Arg Leu Gln Ala Gly Glu Arg Ile Asp Arg Phe Phe Tyr Asn Leu 
        755                 760                 765             


Met Ala Glu Thr Ala Ser Glu Met Arg Val Gln Lys Asp Tyr Ser Ser 
    770                 775                 780                 


Asp Gly Glu Gln Ala Lys Lys Gln Ala Ala Tyr Ile Glu Lys Leu Lys 
785                 790                 795                 800 


Cys Asp Val Val Ala Tyr Ala Leu Ala Asp Tyr Leu Arg Asp Glu Phe 
                805                 810                 815     


Lys Tyr Leu Val Pro Ser Glu Ala Lys Gly Gly Ala Glu Glu Ala Tyr 
            820                 825                 830         


Leu Leu Lys Glu Arg Thr Asp Ser Ala Ala Ala Gln Asp Lys Glu Lys 
        835                 840                 845             


Thr Lys Ala Phe Trp Asp Ala Ile Glu Lys Asp Glu Glu Asp Lys Gln 
    850                 855                 860                 


Lys Lys Glu Gln Ser Glu Trp Asp Lys Leu Thr Glu Glu Gly Lys Phe 
865                 870                 875                 880 


Leu Pro Trp Leu Tyr Phe Leu Leu His Leu Ala Pro Val Glu Glu Val 
                885                 890                 895     


Ala Ser Leu Arg Gln Gln Ile Arg Lys Trp Gln Ile Val Val Thr Lys 
            900                 905                 910         


Leu Glu Asn Asp Lys Ala Gly Asn Glu Asp Ser Gly Glu Gln Lys Ala 
        915                 920                 925             


Gly Lys Arg Thr Glu Val Ala Lys Ile Arg Pro Leu Leu Cys Ala Leu 
    930                 935                 940                 


Asn Leu Tyr Ile Glu Leu His Asp Glu Gln Phe Asn Gln Ala Gly Gln 
945                 950                 955                 960 


Glu Val Pro Ser Leu Ser Asp Glu Asp Lys Lys Gln Leu Glu Gly Tyr 
                965                 970                 975     


Tyr Ala Val Asp Phe Asp Ala Ile Phe Lys Gly Gln Lys Gln Gly Glu 
            980                 985                 990         


Lys Leu Gln Ala Val Arg Gly Trp  Arg Glu Met Arg Arg  Phe Gly Gly 
        995                 1000                 1005             


Asp Thr  Ala Leu Asp Thr Ile  Leu His Glu Trp Asp  His Lys Ile 
    1010                 1015                 1020             


Ser Gln  Asn His Ile Asn Ala  Trp Lys Asp Thr Ser  Gly Asp Thr 
    1025                 1030                 1035             


Ile Ala  Glu Ala Gln Lys Thr  Arg Lys Lys Leu His  Lys Glu Trp 
    1040                 1045                 1050             


Val Lys  Glu Lys Glu Lys Gly  Asn Thr Leu Ser Asp  Lys Glu Lys 
    1055                 1060                 1065             


Lys Asn  Tyr Ala Val Ala Leu  Glu Thr Ile Ile Lys  His Ser Glu 
    1070                 1075                 1080             


Ala Val  Ala Gln Ile Glu Leu  His Asn His Leu Asn  Leu His Lys 
    1085                 1090                 1095             


Leu Leu  Leu Ala Val Leu Gly  Arg Leu Val Asp Phe  Ser Gly Leu 
    1100                 1105                 1110             


Phe Glu  Arg Asp Leu Tyr Phe  Thr Met Leu Ala Leu  Phe Tyr Glu 
    1115                 1120                 1125             


Lys Gln  Gln Arg Glu Asn Phe  Ile Ser Asp Arg Asp  Trp Phe Ala 
    1130                 1135                 1140             


Lys Gln  Phe Thr Asp Ile Val  Glu Val Thr Phe Ala  Ala Pro Leu 
    1145                 1150                 1155             


Glu Glu  Lys Gln Ala Val Gly  Ser Ser Ser Leu Glu  Gln Gly Leu 
    1160                 1165                 1170             


Ile Val  Glu Ala Phe Cys Ala  Leu Cys Asp Thr Asp  Ile Lys Asn 
    1175                 1180                 1185             


Arg Leu  Thr Glu Ile Phe Gly  Val Thr Gly Lys Glu  Glu Gly Ser 
    1190                 1195                 1200             


Thr Lys  Lys Glu Lys Ile Arg  Asn Leu His Asn Thr  Asp Leu Thr 
    1205                 1210                 1215             


Arg Trp  Ile Arg Asn Arg Phe  Ala His Leu Ala Val  Leu Glu Asn 
    1220                 1225                 1230             


Lys Asn  Leu Asp Lys Asn Ile  Asp Val Thr Arg Glu  Leu Asn Phe 
    1235                 1240                 1245             


Ala Arg  Ala Leu Met Ala Tyr  Asp Arg Lys Leu Lys  Asn Ala Val 
    1250                 1255                 1260             


Ala Lys  Ser Ile Thr Glu Met  Leu Ala Arg Gln Lys  Leu Glu Ile 
    1265                 1270                 1275             


Leu Trp  Gln Met Gly Gln Glu  Lys Asn Asp Pro Asp  Ser Val Asp 
    1280                 1285                 1290             


Ser Asn  Asn Pro Val Asp Val  Ala Ile Ala Glu Arg  Lys Ile Lys 
    1295                 1300                 1305             


Val Thr  Ser Arg His Tyr Leu  His Gly Ala Lys Val  Glu Pro Arg 
    1310                 1315                 1320             


Ile Ile  His His Leu Gly Asp  Asn Lys Ala Lys Asp  Leu Gln Glu 
    1325                 1330                 1335             


Asn Leu  Gln Asn Ala Glu Phe  Thr Ser Met Val Gln  Met Leu Phe 
    1340                 1345                 1350             


Gly Gly  Gly Asn Lys Ile Lys  Ala Ala Gly Glu Ala  Lys Glu Lys 
    1355                 1360                 1365             


Ala Glu  Ala Glu Arg Arg Lys  Arg Gln Glu Ala Ala  Lys Lys Gln 
    1370                 1375                 1380             


Gly Lys  Lys Ser Gly Val Val  Arg Phe Phe Asp Ile  Lys Lys Asn 
    1385                 1390                 1395             


Asn Gly  Arg Ile Ile Pro Asp  Glu Gly Glu Arg Asp  Ile Phe Val 
    1400                 1405                 1410             


His Ile  Ser Asp Val Arg Ala  Ser Gly Leu Lys Thr  Leu Lys Lys 
    1415                 1420                 1425             


Gly Gln  Trp Val Ser Tyr Lys  Val Gln Thr Gly Asp  Lys Gly Pro 
    1430                 1435                 1440             


Lys Ala  Val Asn Leu Ser Ile  Ile 
    1445                 1450     


<210>  91
<211>  968
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  91

Met Glu His Arg Ala Ser Ser Ile Ala Lys Asn Val Leu Lys Ile Pro 
1               5                   10                  15      


Ala Ser Lys Asp Ser Asp Lys Glu Asp Ile Ile Lys Ala Gly Asn Ile 
            20                  25                  30          


Thr Ala Lys Ile Lys Ile Ala Tyr Asn Asp Ala Asp Lys Glu Ala Tyr 
        35                  40                  45              


Ser Ala Arg Val Gly Asn Ile Ala Ala Lys Ile Lys Ala Ala Val Leu 
    50                  55                  60                  


Glu Pro Lys Lys Gly Tyr Gln Glu Trp Pro His Glu Ile Ala Ala Arg 
65                  70                  75                  80  


Ile Leu His Glu Thr Ala Phe Cys Lys Phe Lys Gln Phe Ala Asp Met 
                85                  90                  95      


Lys Ala Glu Asn Ser Thr Leu Leu Glu Leu His Cys Gln Ile Lys Ala 
            100                 105                 110         


Ser Tyr Lys Ala Leu Leu Lys Gly His Lys Gln Leu Asn Ala Lys Leu 
        115                 120                 125             


Glu Tyr Val Leu Pro Lys Asp Asn Glu Ala Leu Phe Cys Leu Val Glu 
    130                 135                 140                 


Ala Gln Gln Gln Asn His Arg Ile Asn His Leu Ile Arg Leu Gly Lys 
145                 150                 155                 160 


Ile Val His Tyr Ala Ala Ile Ser Pro Asp Asn Ala Ser Leu Ala Ala 
                165                 170                 175     


Leu Gln Ser Ser Pro Arg Thr Ile Ile Asn Asn Trp Pro Glu Lys Gln 
            180                 185                 190         


Ala Val Glu Glu Ser Arg Phe Trp Ser Ser Ala Gly Gln Thr Glu Ile 
        195                 200                 205             


Lys Gln Asn Glu Ala Phe Val Arg Val Trp Arg Gly Ala Leu Ala Phe 
    210                 215                 220                 


Ala Ala Arg Ser Leu Lys Asp Trp Ala Asp Pro Glu Asp Lys Ile Pro 
225                 230                 235                 240 


Gly Asp Ile Leu Leu Lys Gln Gln Glu Ala Leu Asp Asn Phe Asn Ala 
                245                 250                 255     


Asp Tyr Phe Asn Lys Lys Tyr Gln Ile Leu Phe Gly Gly Gln Cys Gly 
            260                 265                 270         


Leu Ser Ala Lys Glu His Lys Ser Leu Leu Ala Phe Ser Leu Lys Gly 
        275                 280                 285             


Ile Tyr Ala Leu Arg Asn Ala Ala Phe His Phe Asn Ser Leu Thr Val 
    290                 295                 300                 


Phe Val Lys Ala Leu Met Pro Glu Glu Glu Pro Pro Gln Ala Glu Leu 
305                 310                 315                 320 


His Glu Phe Leu Gly Thr Phe Tyr Thr Lys Ser Cys Arg Asp Tyr Arg 
                325                 330                 335     


Leu Lys Gln Lys Lys Ile Met Glu Gly Ala His Phe His Gln Phe Phe 
            340                 345                 350         


Ser Glu Ala Glu Ile Gln Thr Ile Trp Gln Val Leu Thr Ser Ala Lys 
        355                 360                 365             


Pro Gly Ser Leu Pro Leu Pro Arg Leu Lys His Val Leu Glu Arg Ala 
    370                 375                 380                 


Gln Asp Ala Trp Lys Gly Glu Asp Arg Leu Ser Leu Pro Pro Tyr Ser 
385                 390                 395                 400 


Thr Ala Glu Glu Arg Glu Ser Ser Ala Trp Ala His Cys Gln Tyr Thr 
                405                 410                 415     


Ala Val Lys Leu Leu Tyr Asp Gly Arg Phe Arg Asn Trp Leu Glu Glu 
            420                 425                 430         


Arg Asn Gln Ala Ala Val Gly Arg Ile Ile Lys Gln Ala Leu Glu His 
        435                 440                 445             


Thr Ser Gln Ala Ala Gln Asn Ile Ser Ser Arg Gly Lys Asp Lys Glu 
    450                 455                 460                 


Phe Lys Glu Phe Ile Thr Ala Lys Ala Gly Lys Ile Ala Glu Leu Gly 
465                 470                 475                 480 


Asn Lys Glu Asn Phe Lys Thr Leu Phe Ser Ala Leu Met Ala Glu Thr 
                485                 490                 495     


Ala Thr Glu Met Arg Val Gln Lys Phe Tyr Gln Ser Asp Gly Gln Ala 
            500                 505                 510         


Ala Arg Glu Gln Ala Asp Tyr Ile Glu Lys Phe Lys Cys Asp Asn Val 
        515                 520                 525             


Ala Leu Ala Phe Ala Asp Tyr Leu Arg Ala Thr Leu Gly Ala Gly Asn 
    530                 535                 540                 


Val Ala Ala Phe Cys Lys Leu Glu Arg Lys Glu Arg Pro Gly Asp Lys 
545                 550                 555                 560 


Ser Val Tyr Asp Arg Leu Pro Leu Glu Gln Asn Ser Ala Ala Glu Leu 
                565                 570                 575     


Trp Gln Ser Arg Leu Tyr Phe Leu Leu His Leu Met Pro Val Glu Glu 
            580                 585                 590         


Ala Gly Ser Leu Arg Gln Gln Leu Lys Lys Trp Glu Ile Val Thr Asp 
        595                 600                 605             


Lys Ser His Gly Glu Gln Gly Arg Gly Gly Glu Ile Leu Ala Arg Leu 
    610                 615                 620                 


Leu Ala Val Phe Asp Leu Tyr Ile Ala Met His Asp Ala Gln Phe Val 
625                 630                 635                 640 


Gly Ala Glu Leu Val Leu Lys Ser Asp Glu Glu Thr Ala Lys Ala Leu 
                645                 650                 655     


Phe Ala Asn Gln Glu Asp Phe Arg Lys Ser Phe Pro Lys Lys Glu Ser 
            660                 665                 670         


Gly Ala Glu Asp Glu His Leu Pro Ile Arg Gly Leu Arg Glu Met Arg 
        675                 680                 685             


Arg Phe Gly Thr Gly Leu Leu His Asn Leu Tyr Glu Lys His Lys Ile 
    690                 695                 700                 


Ala Ser Ala Ser Val Ala Arg Trp Gln Glu Leu Lys Gln Thr Ile Ala 
705                 710                 715                 720 


Arg Glu Gln Asp Lys Leu Lys Lys Leu His Gly Asp Trp Val Asn Ser 
                725                 730                 735     


Lys Arg Lys Arg His Ala Ile Gln Trp Thr Ser Arg Asp Ala Asn Asp 
            740                 745                 750         


Tyr Asn Glu Thr Leu Ala Leu Val Ile Glu Tyr Arg His Leu Thr Ala 
        755                 760                 765             


Gln Ile Met Leu Gln Asn His Val His Val His Arg Leu Leu Met Lys 
    770                 775                 780                 


Ile Leu Gly Arg Leu Val Asp Phe Ala Gly Leu Trp Glu Arg Asp Leu 
785                 790                 795                 800 


Tyr Phe Val Leu Leu Ala Leu Leu Tyr Gln Lys Gly Met Gly Asp Ile 
                805                 810                 815     


Lys Glu Glu Phe Lys Asp Glu Gly Ala Met Leu Glu Thr Gly Gln Ile 
            820                 825                 830         


Val Lys Ala Leu Arg Lys Leu Lys Asp Thr Asp Arg Arg Ala Glu Ile 
        835                 840                 845             


Ala Ala Phe Leu Asn Lys Glu Glu Val Gly Glu Ile Arg Asn Ser Phe 
    850                 855                 860                 


Tyr His Phe Asp Thr Leu Lys Lys Glu Tyr Phe Pro Ile Asn Leu Thr 
865                 870                 875                 880 


Ala Glu Val Asn Lys Ala Arg Gln Leu Met Ala Tyr Asp Arg Lys Leu 
                885                 890                 895     


Lys Asn Ala Val Thr Lys Ser Leu Val Asp Leu Leu Lys Arg Glu Asn 
            900                 905                 910         


Ile Ile Leu Lys Trp Asp Met Gly Ala Asp His Lys Leu Ser Gly Pro 
        915                 920                 925             


Ile Ser Val Val Ser Ala Lys Thr Cys His Leu Asp Lys Glu Ser Asp 
    930                 935                 940                 


Lys Asn Lys Ile Glu Glu Glu Leu Cys Gly Lys His Phe Ile Ala Met 
945                 950                 955                 960 


Ile Lys Ser Leu Phe Thr Gly Arg 
                965             


<210>  92
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  92

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  93
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  93

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Leu Tyr Gln Ile Val  Ser Ala Phe Asn Phe  Gly Ser Lys 
    1205                 1210                 1215             


Leu Leu  Tyr Ile Ser Glu Asp  Gly Arg Trp Lys Met  Ala Gly Gly 
    1220                 1225                 1230             


Ala Phe  Pro Gly Lys Tyr Gly  Arg Phe Glu Asn Asp  Tyr Asn His 
    1235                 1240                 1245             


Arg Thr  Ser Leu Ser Lys Val  Ile Arg Leu Phe Glu  Asn Glu Ser 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ile Ile Tyr  Trp Arg Asp Tyr Val  Asp His Met 
    1265                 1270                 1275             


Lys Tyr  Tyr Val Asn Gln Asn  Gln Ser Ile Met Glu  Ile Tyr Ser 
    1280                 1285                 1290             


Ala Phe  Tyr Ser Lys Val Leu  Gly Tyr Ser Ala Lys  Leu Arg Lys 
    1295                 1300                 1305             


Ser Val  Val Phe Asn Leu Gln  Ala Ala Leu Glu Lys  His His Ile 
    1310                 1315                 1320             


Asn Pro  Glu Cys Ile Trp Met  Thr Ser Asp Gly Lys  Cys Ala Asp 
    1325                 1330                 1335             


Ile Lys  Leu Met Lys Asn Leu  Glu Ser Gln Lys Phe  Thr Tyr Lys 
    1340                 1345                 1350             


Leu Ala  Lys Arg Glu Gly Glu  Lys Thr Glu Arg Lys  Ile Cys Met 
    1355                 1360                 1365             


Asn Ala  Leu Asn Glu Asn Phe  Leu Lys Thr Ile Arg  Thr Ser Leu 
    1370                 1375                 1380             


Glu Tyr  Lys Lys 
    1385         


<210>  94
<211>  1101
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  94

Met Arg Ile Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Ile Tyr Ser Glu 
            20                  25                  30          


Gln Ala Val Ser Asn Glu Thr Asn Asn Ile Leu Pro Val Lys Lys Met 
        35                  40                  45              


Asp Ser Phe Asn Leu Ser Ile Leu Asn Lys Thr Ile Ile Lys Phe Glu 
    50                  55                  60                  


Thr Val Lys Lys Gln Lys Leu Asn Leu Asp Gln Tyr Lys Ile Val Glu 
65                  70                  75                  80  


Lys Ile Phe Lys Tyr Pro Lys Gln Glu Leu Pro Lys Gln Ile Asn Ala 
                85                  90                  95      


Glu Glu Ile Leu Gln Phe Leu Asn His Lys Phe Gln Glu Pro Val Lys 
            100                 105                 110         


Tyr Trp Lys Asn Gly Lys Glu Glu Ser Phe Asn Leu Thr Leu Leu Ile 
        115                 120                 125             


Val Glu Ala Val Lys Thr Gln Glu Lys Arg Lys Leu Gln Pro Tyr Tyr 
    130                 135                 140                 


Asp Trp Lys Thr Trp Tyr Ile Gln Thr Lys Ser Asp Leu Leu Lys Lys 
145                 150                 155                 160 


Ser Ile Glu Asn Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg 
                165                 170                 175     


Lys Lys Ala Leu Leu Ala Trp Glu Thr Glu Phe Thr Thr Ser Gly Ser 
            180                 185                 190         


Ile Asp Leu Thr His Phe His Lys Val Tyr Met Thr Asp Val Leu Cys 
        195                 200                 205             


Thr Ala Leu Gln Lys Val Glu Pro Ser Ala Asp Glu Arg Gly Lys Met 
    210                 215                 220                 


Asn Ser Asn Ala Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Asn His 
225                 230                 235                 240 


Gln Pro Ala Ile Phe Gly Thr Arg Glu Ala Pro Asn Glu Val Asn Arg 
                245                 250                 255     


Ala Asp Asn Gln Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu 
            260                 265                 270         


Glu His Tyr Phe Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Ala Asp 
        275                 280                 285             


Asp Ile Ser His Tyr Leu Lys Ala Gln Thr Leu Lys Thr Thr Ile Glu 
    290                 295                 300                 


Lys Gln Leu Val Asn Ala Ile Arg Ala Asn Ile Ile Gln Gln Gly Lys 
305                 310                 315                 320 


Thr Asn His His Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile 
                325                 330                 335     


Arg Ile Lys Thr Asn Glu Ala Phe Val Leu Asn Leu Ile Gly Thr Cys 
            340                 345                 350         


Ala Phe Ala Ala Asn Asn Ile Arg Asn Met Val Asp Lys Glu Gln Ile 
        355                 360                 365             


Ser Asp Ile Leu Gly Lys Arg Glu Phe Ile Asp Ser Leu Thr Lys Ser 
    370                 375                 380                 


Arg Ile Ser Ser Gln Leu Tyr Ser Phe Phe Phe Gly Glu Asn Leu Ser 
385                 390                 395                 400 


Thr Asn Lys Ala Glu Lys Glu Thr Gln Leu Trp Gly Ile Arg Gly Ala 
                405                 410                 415     


Val Gln Gln Ile Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu 
            420                 425                 430         


Thr Thr Ile Phe Asn Ile Cys Lys Phe Glu Asn Pro Thr Asp Ala Asp 
        435                 440                 445             


Pro Lys Gln Gln Thr Asn Tyr Val Asp Ser Ile Tyr Lys Thr Leu Phe 
    450                 455                 460                 


Ile Lys Glu Leu Glu Lys Ile Pro Glu Ala Phe Ala Gln Gln Leu Lys 
465                 470                 475                 480 


Thr Gly Gly Ala Leu Ser Tyr Tyr Thr Val Glu Asn Leu Lys Thr Leu 
                485                 490                 495     


Leu Thr Thr Phe Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala 
            500                 505                 510         


Pro Gly Phe Lys Lys Val Leu Asn Gly Gly Ile Asn Tyr Gln Asn Ala 
        515                 520                 525             


Lys Gln Asp Glu Ser Phe Tyr Glu Leu Met Leu Glu Arg Tyr Leu Arg 
    530                 535                 540                 


Lys Glu Asn Phe Ala Glu Glu Ala Tyr Asn Ala Arg Tyr Phe Leu Leu 
545                 550                 555                 560 


Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Lys Phe Thr Ala Asp Arg 
                565                 570                 575     


Lys Ala Phe Ala Asp Ser Val Gly Phe Val Gln Leu Gln Asn Arg Lys 
            580                 585                 590         


Gln Ala Glu Asn Ser Lys Arg Pro Lys Ala Phe Ala Phe Glu Ala Val 
        595                 600                 605             


Arg Pro Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala Tyr Val 
    610                 615                 620                 


Gln Ser Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys Ala Thr 
625                 630                 635                 640 


Asp Glu Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val Phe Ile 
                645                 650                 655     


Lys Gly Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe Val Gln 
            660                 665                 670         


Val Pro Gln Pro Gln Leu Thr Thr Thr Asp Ser Asn Gln Gln Lys Ala 
        675                 680                 685             


Asp Lys Leu Asn Gln Leu Glu Ala Ser Ile Thr Ala Asp Cys Lys Leu 
    690                 695                 700                 


Thr Ala Gln Tyr Ala Lys Thr Asp Asp Ala Thr His Ile Ala Phe Tyr 
705                 710                 715                 720 


Val Phe Cys Lys Leu Leu Asp Ala Gly His Leu Ser Asn Leu Arg Asn 
                725                 730                 735     


Glu Leu Ile Lys Phe Arg Gly Ser Val Lys Asp Phe Asp Phe His His 
            740                 745                 750         


Leu Leu Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val Val Pro 
        755                 760                 765             


Thr Asp Tyr Arg Asp Leu Tyr Ser Ser Gly Ala Asp Cys Leu Ala Arg 
    770                 775                 780                 


Leu Arg Pro Phe Ile Glu Gln Gly Ala Asp Ile Lys Asn Trp Ser Asp 
785                 790                 795                 800 


Leu Tyr Val Gln Thr Asp Lys Gln Thr Pro Val Ile His Ala Gly Ile 
                805                 810                 815     


Glu Leu Ser Val Lys Tyr Gly Thr Thr Ala Leu Leu Glu Gln Leu Ile 
            820                 825                 830         


Thr Cys Asn Pro Lys Phe Arg Val Met Glu Asp Asn Phe Thr Lys Trp 
        835                 840                 845             


Ser Ala Gln Lys Lys Glu Ile Glu Glu Lys Val Asn Lys His Thr Asn 
    850                 855                 860                 


Leu His Gln Gln Trp Val Glu Ala Lys Glu Lys Asp Asp Arg Glu Arg 
865                 870                 875                 880 


Val Lys Ser Lys Lys Asn Phe Val Arg Glu Tyr Val Lys Lys Asn Tyr 
                885                 890                 895     


Val Asp Tyr Ile Asn Asn Cys Ile Glu Ile Asn Asn Tyr Asn Trp Leu 
            900                 905                 910         


Asp Asn Lys Leu His Phe Val His Leu Asn His Leu His His Leu Thr 
        915                 920                 925             


Ile Asp Ile Leu Gly Arg Met Ala Gly Phe Val Ala Leu Trp Glu Arg 
    930                 935                 940                 


Asp Phe Gln Tyr Ile Thr Lys Tyr Thr Ala Ala Lys Glu Gly Thr Asp 
945                 950                 955                 960 


Ala Leu Ser Phe Asp Gly Gly Leu Pro Arg Leu Lys Asp Lys Gln Glu 
                965                 970                 975     


Tyr Tyr Asn Lys Leu Phe Leu Ser Asp Lys Tyr Thr Lys Val Arg Asn 
            980                 985                 990         


His Ile Ala His Phe Asn Tyr Leu  Thr Lys Asp Ala Ala  Asp Phe Ala 
        995                 1000                 1005             


Leu Leu  Asp Leu Ile Asn Glu  Leu Arg Glu Leu Leu  His Tyr Gly 
    1010                 1015                 1020             


Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ala Phe Ile  Asp Leu Phe 
    1025                 1030                 1035             


Glu Lys  His Gly Met Ile Leu  Lys Leu Lys Leu Asn  Thr Asp His 
    1040                 1045                 1050             


Gln Leu  Val Val Glu Ser Ile  Glu Pro Lys Lys Ile  Tyr His Leu 
    1055                 1060                 1065             


Gly Ser  Thr Ala Lys Asp Lys  Pro Glu Tyr Gln Tyr  Thr Thr Asn 
    1070                 1075                 1080             


Gln Val  Met Thr Val Tyr Cys  Asn Met Cys Arg Ser  Leu Leu Glu 
    1085                 1090                 1095             


Met Lys  Lys 
    1100     


<210>  95
<211>  949
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  95

Met Pro His Gln Lys Lys Met Ala Glu Arg Ile Lys Phe Val Asn Tyr 
1               5                   10                  15      


Gly Tyr Tyr Leu Arg Leu Lys Lys Asn Cys Ala Asp Ser Phe Glu Tyr 
            20                  25                  30          


Tyr Trp Cys Asp Tyr Ile Lys Glu Phe Ile Glu Glu Asn Tyr Val Thr 
        35                  40                  45              


Lys Ile Lys Glu Ala Lys Gly Lys Asn Gly Arg Gln Leu Thr Glu Glu 
    50                  55                  60                  


Asn Cys Asn Ser Glu Ala Met Leu Ser Lys Cys Trp His Asp Met Ile 
65                  70                  75                  80  


Arg His Met Cys Ala Lys Tyr Met Asp Leu Gly Lys Ala Val Tyr His 
                85                  90                  95      


Phe Met Leu Pro Gly Lys Ala Glu Gly Asn Asp Leu Cys Leu Asp Arg 
            100                 105                 110         


Leu Asn Asp Ser Phe Ser Lys Gly Ile Thr Ser Phe Asp Tyr Glu Asn 
        115                 120                 125             


Ile Lys Ala Glu Glu Asn Leu Gln Lys Ala Met Phe Gly Val Leu Val 
    130                 135                 140                 


Ser Gly Thr Phe Asn Phe Ser Arg Ser Val Ala Asp Tyr Ser Gly Pro 
145                 150                 155                 160 


Ala Ala Ala Lys Leu Ala Lys Glu Leu Arg Ala Glu Gly Lys Thr Leu 
                165                 170                 175     


Asn Glu Asp Val Leu Met Val Asp Glu Ala His Leu Lys Ala Ile Leu 
            180                 185                 190         


Tyr Ser Asp Ala Lys Arg Lys Leu Leu Arg Tyr Phe Gly Gly Ser Ser 
        195                 200                 205             


Ala Cys Glu Ala Leu Gly Leu Asp Lys Asp Lys Met Val Leu Glu Phe 
    210                 215                 220                 


Arg Gln Ile Phe Arg Gly Leu Arg Asn Ser Ala Phe His Tyr Thr Asp 
225                 230                 235                 240 


Gly Lys Lys Ala Asp Ile Lys Phe Asp Val Thr Arg Gln Leu Trp Ile 
                245                 250                 255     


Gln Asp Val Gln Ala Asn Lys Gln Leu Ile Leu Asp Lys Tyr Tyr Ser 
            260                 265                 270         


Asn Asn Val Cys Arg Tyr Tyr Lys Pro Glu Met Val Lys Lys Leu Ile 
        275                 280                 285             


Gly Asn Leu Tyr His Gly Tyr Val Glu Gln Glu Ala Gln Ile Pro Ala 
    290                 295                 300                 


Phe Arg Thr Val Trp Lys Arg Lys Asp Phe Ala Lys Tyr Leu Asn Asp 
305                 310                 315                 320 


Ser Asn Phe Leu Pro Val Asn Ile Lys Asn Asp Val Lys Glu Arg Thr 
                325                 330                 335     


Val Phe Glu Gly Ala Leu Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg 
            340                 345                 350         


Lys Tyr Thr Val Gly Gln Asp Ala Pro Lys Tyr Phe Phe Glu Ala Val 
        355                 360                 365             


Arg Ala Tyr Ser Asp Glu His Ala Lys Asn Lys Gln Asp Pro Tyr Ala 
    370                 375                 380                 


Asn Gln Ala Lys Asn Phe Trp Asp Tyr Val Glu Lys Leu Gln Lys Ser 
385                 390                 395                 400 


Tyr Glu Lys Gly Thr Leu Thr Phe Gly Ala Val Cys Gln Thr Ile Met 
                405                 410                 415     


Thr Glu Phe Val Gln Gln Asn Ser Lys Ala Thr Glu Lys Glu Gly Glu 
            420                 425                 430         


Ile Tyr Gln His Phe Lys Val Leu Phe Pro Leu Cys Met Gln Arg Gly 
        435                 440                 445             


Phe Glu Lys Tyr Val Lys Glu Lys His Gly Tyr Leu Leu Lys Pro Trp 
    450                 455                 460                 


Leu Asp Thr Val Val Arg Glu Asn Val Leu Gln Asp Ala Ala Ile Thr 
465                 470                 475                 480 


Cys Phe Asp Asp Leu Met Arg Asp Ala Glu Asp Arg Glu Tyr Ser Trp 
                485                 490                 495     


Tyr Val Val Ala His Phe Ile His Pro Lys Lys Leu Asn His Phe Val 
            500                 505                 510         


Gly Ala Leu Lys Asp Tyr Leu Gln Phe Lys Gln Asp Ile Phe Arg Arg 
        515                 520                 525             


Cys Ser Phe Ala Asn Ile Tyr Ser Glu Gly Glu Leu Ser Gln Lys Lys 
    530                 535                 540                 


Ala Met Leu Ala Glu Lys Glu Ala Glu Ile Ser Glu Ile Leu Arg Val 
545                 550                 555                 560 


Met Glu Phe Val Arg Gly Ile Thr Gly Arg Val Ser Lys Thr Phe Ser 
                565                 570                 575     


Asp Tyr Tyr Glu Asn Glu Glu Val Tyr Ala Asn Tyr Leu Gly Lys Tyr 
            580                 585                 590         


Ile Asp Phe Pro Lys Thr Asp Gly Ile Ser Val Phe Glu Ser Phe Arg 
        595                 600                 605             


Asp Phe Cys Thr Asn Thr Leu Pro Asp Gly Asn Val Leu Asp Val Tyr 
    610                 615                 620                 


Met Asp Glu Lys Asn Pro Arg Leu Leu Lys Asn Val Glu Leu Ala Arg 
625                 630                 635                 640 


Met Tyr Ala Gly Gly Asp Val Ala Leu Lys Lys Arg Lys Arg Ile Thr 
                645                 650                 655     


Ala Lys Asp Leu Gln Arg Tyr Tyr Gly Asn Glu Val Ala Val Gln Lys 
            660                 665                 670         


Ile Leu Gln Lys Gly Leu Cys Ser Thr Arg Glu Glu Gln Gln Arg Val 
        675                 680                 685             


Leu Glu Gln Gln Asn Leu Arg Gly Arg Ile Thr Leu Asn Asp Val Thr 
    690                 695                 700                 


Glu Ile Gln Glu Ile Ile Ser Asp Met Leu Ser Gln Leu Val Thr Phe 
705                 710                 715                 720 


Ser Tyr Phe Arg Glu Arg Asp Gln Met Tyr Leu Leu Leu Gly Phe Tyr 
                725                 730                 735     


Tyr Met Ala Leu Gln Thr Asn Arg Gly Ser Ser Trp Gly Asn Glu Thr 
            740                 745                 750         


Ile Asp Phe Cys Ala Gly Lys Lys Ile Ser Ile Lys Gln Gly Trp Val 
        755                 760                 765             


Leu His Gln Val Arg Ser Val Phe Thr Tyr Gly Leu Lys Leu Tyr Ser 
    770                 775                 780                 


Glu Leu Asp Glu Lys Gly Val Gly Gly Gln Leu Ser Ser Lys Ile Val 
785                 790                 795                 800 


Ala Phe Glu Arg Val His Arg Thr Ser Leu Ala Cys Ala Leu Arg Leu 
                805                 810                 815     


Phe Met Asp Glu Asn Cys Ser Arg Arg Ala Val Asp Val Arg Asn Tyr 
            820                 825                 830         


Val Asp His Phe Lys Tyr Tyr Phe Lys Ala Asp Arg Ser Ile Met Glu 
        835                 840                 845             


Leu Tyr Ser Ala Tyr Tyr Asp Cys Phe Phe Asp Tyr Ser Thr Lys Met 
    850                 855                 860                 


Arg Lys Ser Val Leu Leu Asn Phe Ile Ser Ile Leu Glu Arg His Phe 
865                 870                 875                 880 


Val Val Ser Lys Leu Arg Val Asn Cys Leu Glu Glu Arg Cys Ser Val 
                885                 890                 895     


Ser Phe Ala Glu Ser Leu Lys Ser Glu Lys Phe Thr Tyr Lys Leu Glu 
            900                 905                 910         


Ala Asp Ala Asn Lys Lys Ser Lys Glu Gln Thr Val Glu Phe Pro Ala 
        915                 920                 925             


Arg Asp Lys Glu Phe Leu Glu Ser Leu Gln Ala Glu Leu Glu Tyr Lys 
    930                 935                 940                 


Glu Gly Tyr Asn Ser 
945                 


<210>  96
<211>  1258
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  96

Met Arg Gly Gly His Met Lys Ile Thr Lys Ile Asp Gly Ile Ser His 
1               5                   10                  15      


Tyr Lys Glu Lys Glu Lys Gly Val Leu Lys Ala Lys Asp Val Leu Leu 
            20                  25                  30          


Asn Gly Glu Ile Lys Glu Ile Val Lys Lys Arg Tyr Asp Ala Thr Ile 
        35                  40                  45              


Glu Ser Lys Ile Tyr Lys Glu Phe Ile Lys Leu Arg Lys Asn Arg Val 
    50                  55                  60                  


Glu His Asn Asn Glu Lys Ser Val Leu Glu Leu Ile Lys Ser Asn Ile 
65                  70                  75                  80  


Asp Lys Asn Glu Lys Glu Ile Lys Thr Leu Leu Leu Asp Glu Phe Lys 
                85                  90                  95      


Ile Lys Glu Lys Asn Lys Lys Tyr Asp Lys Tyr Met Ser Asp Lys Asn 
            100                 105                 110         


Glu Leu Asp Asn Asp Ile Gln Ile Tyr Glu Ser Val Glu Ser Leu Tyr 
        115                 120                 125             


Phe Phe Ile Lys Glu Val Tyr Ser Gly Lys Asn Asn Asp Lys Trp Asp 
    130                 135                 140                 


Ile Ser Lys Ile Asp Leu Glu Lys Ile Met Glu Lys Asp Asn Asn Leu 
145                 150                 155                 160 


Ile Met Leu Gly Tyr Lys Leu Lys Lys Asn Ile Lys Glu Asp Glu Tyr 
                165                 170                 175     


Pro Tyr Leu Tyr Lys Asn Glu Asn Arg Glu Lys Ser Thr Pro Leu Tyr 
            180                 185                 190         


Thr Leu Leu Lys Lys Leu Ile Glu Glu Asn Lys Asp Ser Asn Gln Asn 
        195                 200                 205             


Ile Arg Glu Ser Gln Glu Tyr Arg Lys Ile Gln Lys Asp Phe Lys Glu 
    210                 215                 220                 


Tyr Lys Asn Ile Lys Ile Asn Leu Leu Val Lys Ser Ile Leu Asn Asn 
225                 230                 235                 240 


Lys Val Asn Ile Lys Tyr Asn Thr Ser Asn Asn Asn Ile Glu Asp Ser 
                245                 250                 255     


Asn Ser Lys Arg Glu Lys Glu Ile Ile Glu Phe Phe Lys Lys Met Ile 
            260                 265                 270         


Glu Glu Lys Asn Lys Pro Ile Leu Glu Asp Arg Leu Lys Leu Phe Lys 
        275                 280                 285             


Leu Glu Val Phe Phe Asp Glu Glu Phe Leu Glu Glu Ile Lys Lys Leu 
    290                 295                 300                 


Leu Asp Ser Asp Asn Leu Asp Lys Ser Asp Asn Lys Lys Ile Ala Glu 
305                 310                 315                 320 


Leu Arg Gly Lys Ile Phe Ser Arg Ile Arg Glu Lys Ile Lys Glu Asp 
                325                 330                 335     


Lys Asn Arg Tyr Ile Leu Lys Asn Ile Tyr Phe Leu Glu Leu Lys Lys 
            340                 345                 350         


Tyr Ile Glu Asn Asn Leu Ser His Lys Lys Glu Asn Asn Lys Asn Asn 
        355                 360                 365             


Ser Asn Ile Gly Glu Glu Lys Ser Lys Glu Leu Tyr Leu Lys Phe Leu 
    370                 375                 380                 


Lys Lys Ile Leu Phe Ile Asp Asp Asn Asn Arg Ile Ser Ile Glu Lys 
385                 390                 395                 400 


Leu Lys Ser Arg Ile Asp Asp Asn Phe Lys Asn Leu Leu Ile Gln His 
                405                 410                 415     


Val Ile Glu Tyr Gly Lys Ile Lys Tyr Tyr Val Glu Asn Asp Asp Tyr 
            420                 425                 430         


Ile Lys Asn Ile Val Lys Asn Gly Glu Leu Lys Leu Glu Thr Glu Asn 
        435                 440                 445             


Leu Glu Tyr Ile Arg Ile Arg Glu Thr Leu Ile Arg Lys Met Ala Val 
    450                 455                 460                 


Leu Val Ser Phe Ala Ala Asn Ser Phe Tyr Asn Leu Phe Glu Asn Ile 
465                 470                 475                 480 


Thr Ser Asp Ile Leu Thr Ala Asn Ile Asn Leu Asp Ser Asp Val Ile 
                485                 490                 495     


Lys Ile Gly Asn Asn Arg Leu Lys Glu Lys Phe Leu Asn Tyr Phe Phe 
            500                 505                 510         


Tyr Ser Glu Glu Ile Ser Asp Lys Glu Asp Phe Leu Lys Ala Leu Lys 
        515                 520                 525             


Asp Ser Ile Tyr Asn Val Arg Asn Gly Val Asn His Phe Asp Lys Met 
    530                 535                 540                 


Ile Leu Gly Lys Tyr Asn Asn Gly Leu Asp Leu Lys Asp Ser Asp Thr 
545                 550                 555                 560 


Ile Lys Asp Tyr Phe Asn Phe Lys Lys Lys Glu Ile Gln Gln Asp Leu 
                565                 570                 575     


Lys Asp Arg Phe Ile Ser Asn Asn Leu Gln Tyr Tyr Tyr Thr Glu Asn 
            580                 585                 590         


Glu Ile Lys Lys Tyr Phe Glu Lys Tyr Lys Phe Glu Ile Leu Lys Thr 
        595                 600                 605             


Lys Ala Ser Phe Ala Pro Asn Phe Lys Arg Ile Leu Arg Lys Gly Glu 
    610                 615                 620                 


Asn Leu Ser Ile Ser Glu Ile Ser Asp Ile Tyr Asp Phe Phe Lys Arg 
625                 630                 635                 640 


Tyr Ser Glu Asn Ser Asp Lys Ser Ser Glu Tyr Asn Glu Phe Thr Lys 
                645                 650                 655     


Thr Arg Asn Phe Leu Leu Lys Glu Leu Tyr Tyr Asn Asn Phe Tyr Arg 
            660                 665                 670         


Glu Phe Leu Ser Asp Gly Thr Lys Phe Glu Glu Ala Val Lys Lys Val 
        675                 680                 685             


Lys Asn Asn Lys Lys Asn Arg Ile Ile Gly Asn Lys Lys Ser Ala Gly 
    690                 695                 700                 


Lys Ser Tyr Asp Val Ile Glu Asp Tyr Asn Ser Ser Asp Asp Val Leu 
705                 710                 715                 720 


Glu Tyr Ile Ser Arg Ile His Lys Ser Glu Met Glu Arg Ile Glu Ile 
                725                 730                 735     


Asn Thr Glu Lys Asn Arg Lys Asp Thr Ser Lys Tyr Ile Arg Asp Phe 
            740                 745                 750         


Ile Glu Glu Val Phe Leu Glu Gly Phe Ile Lys Tyr Leu Asp Asn Asn 
        755                 760                 765             


Asn Leu Asn Phe Leu Lys Asn Arg Asn Lys Val Asp Lys Glu Arg Lys 
    770                 775                 780                 


Glu Ile Ile Arg Asn Leu Lys Ile Lys Ile Glu Gly Leu Asp Ile Leu 
785                 790                 795                 800 


Asn Gln Asn Asp Ser Glu Ile Leu Asn Leu Tyr Leu Phe Phe Asn Met 
                805                 810                 815     


Ile Asp Asn Lys Arg Ile Ser Glu Phe Arg Asn Glu Met Ile Lys Tyr 
            820                 825                 830         


Lys Gln Phe Leu Thr Lys Arg Gln Asn Ile Lys Ser Lys Phe Leu Glu 
        835                 840                 845             


Ile Asp Ile Glu Lys Ile Glu Ala Ile Ile Glu Phe Val Ile Ile Thr 
    850                 855                 860                 


Arg Gly Lys Leu Glu Ile Leu Glu Gly Glu Thr Lys Glu Gln Lys Lys 
865                 870                 875                 880 


Asp Asn Met Asn Ala Leu Phe Asn Lys Phe Tyr Ser Ser Glu Ser Glu 
                885                 890                 895     


Tyr Asp Glu Ser Leu Lys Lys Phe Ile Glu Glu Thr Val Leu Asn Asn 
            900                 905                 910         


Lys Lys Asn Thr Pro Phe Tyr Ser Thr Asp Gly Lys Thr Pro Ile Val 
        915                 920                 925             


His Ser Asn Leu Glu Lys Met Arg Lys Tyr Gly Thr Glu Asn Phe Leu 
    930                 935                 940                 


Ser Lys Val Leu Lys Asp Glu Lys Tyr Thr Leu Glu Asn Met Lys Ile 
945                 950                 955                 960 


Lys Glu Lys Phe Glu Thr Glu Ala Asn Asp Lys Phe Lys Glu Gln Lys 
                965                 970                 975     


Ile Leu Glu Lys Val Asp Lys Ile Lys Gly Asn Glu Lys His Lys Lys 
            980                 985                 990         


Leu Ile Glu Tyr Tyr Asn Asp Cys  Arg Cys Tyr Leu His  Lys Glu Trp 
        995                 1000                 1005             


Ile Lys  Asn Lys Lys Asn Lys  Glu Glu Phe Glu Tyr  Lys Glu Ile 
    1010                 1015                 1020             


Tyr Glu  Lys Ile Ile Glu Glu  Ile Arg Lys Tyr Asn  Tyr Leu Glu 
    1025                 1030                 1035             


Asn Lys  Glu Lys Leu Gln Asn  Val Tyr Leu Leu His  Glu Ile Thr 
    1040                 1045                 1050             


Ser Asp  Leu Met Ala Arg Asn  Val Ala Phe Ile Asn  Lys Trp Glu 
    1055                 1060                 1065             


Arg Asp  Phe Lys Phe Leu Ser  Ile Ala Ile Lys Glu  Asn Leu Lys 
    1070                 1075                 1080             


Asp Ser  Asn Asp Ile Gln Lys  Ile Lys Glu Phe Leu  Ala Pro Ser 
    1085                 1090                 1095             


Leu Asp  Thr Thr Ser Asp Glu  Glu His Phe Asn Val  Lys Asn Tyr 
    1100                 1105                 1110             


Ala Ser  Lys Leu Lys Asn Ile  Gln Gly Leu His Asn  Asn Ile Ile 
    1115                 1120                 1125             


Ser Leu  Ile Phe Ile Lys Asn  Leu Asp Gly Trp Ser  Asn Lys Ile 
    1130                 1135                 1140             


Asp Asn  Phe Lys Trp Leu Gly  Phe Arg Asn Tyr Ile  Ser His Phe 
    1145                 1150                 1155             


Asn His  Ile Asn Gly Glu Asn  Ser Lys Glu Ser Phe  Ile Asn Gln 
    1160                 1165                 1170             


Leu Asn  Arg Leu Val Leu Leu  Phe Ser Tyr Asp Lys  Lys Val Gln 
    1175                 1180                 1185             


Asn His  Ile Thr Lys Ser Ile  Lys Thr Ile Leu Glu  Lys Tyr Asn 
    1190                 1195                 1200             


Ile Asp  Ile Glu Phe Lys Ile  Ser Asp Asp Ser Lys  Asn Phe Phe 
    1205                 1210                 1215             


Glu Tyr  Gln Ile Ser Asn Ile  Asn Ser Lys Lys Gly  Lys Met Leu 
    1220                 1225                 1230             


Gly Lys  Glu Asn Tyr Phe Glu  Leu Leu Asp Glu Glu  Phe Val Gln 
    1235                 1240                 1245             


Asn Val  Lys Lys Met Leu Glu  Tyr Glu Asp 
    1250                 1255             


<210>  97
<211>  1118
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  97

Met Lys Gly Gly Ser Met Lys Ile Thr Lys Val Asp Gly Leu Ser His 
1               5                   10                  15      


Tyr Lys Lys Gln Asp Lys Gly Val Leu Lys Lys Lys Arg Lys Asp Leu 
            20                  25                  30          


Asp Glu Arg Lys Gln Arg Glu Lys Ile Glu Glu Arg Tyr Asn Lys Gln 
        35                  40                  45              


Ile Glu Ser Lys Ile Tyr Lys Glu Phe Phe Arg Leu Lys Asn Lys Lys 
    50                  55                  60                  


Arg Ile Glu Lys Glu Glu Asp Gln Asn Ile Lys Ser Leu Tyr Phe Phe 
65                  70                  75                  80  


Ile Lys Glu Met Tyr Leu Asn Glu Lys Asn Glu Glu Trp Glu Leu Lys 
                85                  90                  95      


Asn Ile Asn Leu Glu Ile Leu Asp Asp Lys Glu Arg Val Ile Lys Gly 
            100                 105                 110         


Tyr Lys Phe Lys Glu Asp Val Tyr Phe Phe Lys Glu Gly Asp Lys Glu 
        115                 120                 125             


Tyr Tyr Leu Arg Thr Leu Leu Asn Asn Leu Ile Glu Lys Val Gln Asn 
    130                 135                 140                 


Glu Asn Lys Glu Lys Val Arg Lys Asn Lys Glu Phe Leu Asp Leu Lys 
145                 150                 155                 160 


Glu Ile Phe Lys Lys Tyr Lys Asp Arg Lys Ile Asp Leu Leu Leu Lys 
                165                 170                 175     


Ser Ile Asn Asn Asn Lys Ile Asn Leu Glu Tyr Lys Lys Glu Asn Val 
            180                 185                 190         


Asn Glu Glu Ile Tyr Gly Ile Asn Pro Thr Asn Asp Arg Glu Met Thr 
        195                 200                 205             


Phe Tyr Glu Leu Leu Lys Glu Ile Ile Glu Lys Lys Asp Glu Gln Lys 
    210                 215                 220                 


Ser Ile Leu Glu Glu Lys Leu Asp Asn Phe Asp Ile Thr Asn Phe Leu 
225                 230                 235                 240 


Glu Asn Ile Glu Lys Ile Phe Asn Glu Glu Thr Glu Ile Asn Ile Ile 
                245                 250                 255     


Lys Gly Lys Val Leu Asn Glu Leu Arg Glu Tyr Ile Lys Glu Lys Glu 
            260                 265                 270         


Glu Asn Asn Ser Asp Asn Lys Leu Lys Gln Ile Tyr Asn Leu Glu Leu 
        275                 280                 285             


Lys Lys Tyr Ile Glu Asn Asn Phe Ser Tyr Lys Lys Gln Lys Ser Lys 
    290                 295                 300                 


Ser Lys Asn Gly Lys Asn Asp Tyr Leu Tyr Leu Asn Phe Leu Lys Lys 
305                 310                 315                 320 


Ile Met Phe Ile Glu Glu Val Asp Glu Lys Lys Glu Ile Asn Lys Glu 
                325                 330                 335     


Lys Phe Lys Asn Lys Ile Asn Ser Asn Phe Lys Asn Leu Phe Val Gln 
            340                 345                 350         


His Ile Leu Asp Tyr Gly Lys Leu Leu Tyr Tyr Lys Glu Asn Asp Glu 
        355                 360                 365             


Tyr Ile Lys Asn Thr Gly Gln Leu Glu Thr Lys Asp Leu Glu Tyr Ile 
    370                 375                 380                 


Lys Thr Lys Glu Thr Leu Ile Arg Lys Met Ala Val Leu Val Ser Phe 
385                 390                 395                 400 


Ala Ala Asn Ser Tyr Tyr Asn Leu Phe Gly Arg Thr Glu Asn Asn Ile 
                405                 410                 415     


Leu Thr Gln Glu Ile Ser Asp Asp Leu Leu Leu Gly Lys Ile Glu Asn 
            420                 425                 430         


Glu Ile Tyr Ile Lys Gly Glu Lys Asn Arg Arg Tyr Val Phe Lys Glu 
        435                 440                 445             


Lys Met Leu Asn Tyr Phe Phe Asn Pro Glu Ile Phe Gly Asp Asn Lys 
    450                 455                 460                 


Ile Val Glu Val Leu Ser Ala Ile Ser Ser Ser Ile Tyr Asn Ile Arg 
465                 470                 475                 480 


Asn Gly Val Asn His Phe Asp Lys Met Val Leu Gly Lys Tyr Asn Asn 
                485                 490                 495     


Glu Leu Asp Leu Lys Asp Ser Asp Thr Ile Lys Asp Tyr Phe Asn Phe 
            500                 505                 510         


Lys Lys Lys Glu Ile Gln Gln Asp Leu Lys Asp Arg Phe Ile Ser Asn 
        515                 520                 525             


Asn Leu Gln Tyr Tyr Tyr Thr Glu Asn Glu Asn Asn Lys Ala Lys Phe 
    530                 535                 540                 


Arg Glu Ala Val Glu Lys Val Lys Lys Asn Lys Lys Arg Arg Gly Gly 
545                 550                 555                 560 


Lys Ser Tyr Asp Val Ile Gly Asn Tyr Asn Phe Ser Asp Ser Ile Ser 
                565                 570                 575     


Glu Tyr Ile Ser Tyr Ile His Lys Ser Glu Met Glu Arg Ile Glu Ile 
            580                 585                 590         


Asn Thr Glu Lys Asn Arg Lys Asp Thr Ser Lys His Ile Arg Asp Phe 
        595                 600                 605             


Ile Glu Glu Ile Phe Leu Glu Gly Phe Ile Glu Tyr Leu Asn Asn Asn 
    610                 615                 620                 


Asn Phe Lys Phe Leu Lys Asn Arg Asn Glu Val Asp Lys Glu Arg Glu 
625                 630                 635                 640 


Glu Ile Val Arg Asn Leu Asn Ile Arg Ile Glu Gly Leu Asp Ile Leu 
                645                 650                 655     


Asn Glu Asp Asp Ser Glu Ile Leu Asn Leu Tyr Leu Phe Phe Asn Met 
            660                 665                 670         


Ile Asp Asn Lys Arg Ile Ser Glu Phe Arg Asn Asp Met Ile Lys Tyr 
        675                 680                 685             


Lys Gln Phe Leu Ala Lys Arg Gln Asn Ile Asp Ser Lys Phe Leu Lys 
    690                 695                 700                 


Ile Asp Ile Glu Lys Ile Glu Ala Ile Ile Glu Phe Val Ile Ile Thr 
705                 710                 715                 720 


Lys Glu Lys Leu Glu Ile Leu Glu Gly Glu Thr Lys Glu Gln Lys Lys 
                725                 730                 735     


Asp Asn Met Asn Ala Leu Phe Asn Lys Phe Tyr Ser Ser Glu Ser Glu 
            740                 745                 750         


Tyr Asp Glu Lys Leu Lys Lys Phe Ile Glu Glu Ala Ile Leu Gly Asp 
        755                 760                 765             


Lys Lys Asn Thr Pro Phe Tyr Ser Thr Asp Gly Lys Thr Pro Ile Val 
    770                 775                 780                 


His Ser Lys Leu Glu Lys Met Arg Lys Tyr Gly Thr Glu Asn Phe Leu 
785                 790                 795                 800 


Ser Lys Val Leu Lys Asn Ser Lys Tyr Thr Leu Asn Asn Met Thr Ala 
                805                 810                 815     


Lys Glu Lys Phe Glu Ala Glu Val Ser Asp Glu Leu Lys Glu Tyr Lys 
            820                 825                 830         


Ile Leu Glu Lys Val Ser Arg Phe Lys Glu Lys Gly Lys Pro Lys Lys 
        835                 840                 845             


Val Ile Glu Tyr Tyr Asn Asp Cys Arg Cys Tyr Leu His Lys Lys Trp 
    850                 855                 860                 


Ile Glu Lys Lys Lys Ser Glu Glu Glu Phe Glu His Lys Glu Ile Tyr 
865                 870                 875                 880 


Lys Lys Ile Ile Glu Glu Ile Arg Lys Tyr Asn Tyr Leu Glu Asn Lys 
                885                 890                 895     


Glu Lys Leu Gln Asn Val Tyr Leu Leu His Glu Met Leu Ser Asp Leu 
            900                 905                 910         


Leu Ala Arg Asn Val Ala Phe Phe Asn Lys Trp Glu Arg Asp Phe Lys 
        915                 920                 925             


Phe Ile Val Ile Ala Ile Lys Gln Phe Leu Arg Glu Asn Asp Lys Glu 
    930                 935                 940                 


Lys Val Asn Glu Phe Leu Asn Pro His Lys Ser Asp Gly Ser Arg Asp 
945                 950                 955                 960 


Asn Phe Ser Val Thr Asn Tyr Arg Ser Lys Met Lys Ser Ile Ile Asn 
                965                 970                 975     


Asn Ile His Glu Asn Phe Met Ser Leu Leu Phe Leu Asn Asn Asn Leu 
            980                 985                 990         


Ala Thr Gly Gly Ile Gln Val Gly  Arg Asn Asn Asn Phe  Thr Trp Gly 
        995                 1000                 1005             


Ala Leu  Arg Asn Tyr Ile Ala  His Phe Glu Tyr Leu  His Glu Glu 
    1010                 1015                 1020             


Lys Asp  Thr Ile Ser Phe Ile  Gly Gln Ala Asn Leu  Leu Ile Lys 
    1025                 1030                 1035             


Leu Phe  Ser Tyr Asp Lys Lys  Val Gln Asn His Ile  Leu Lys Ser 
    1040                 1045                 1050             


Thr Lys  Thr Leu Leu Glu Lys  Tyr Asn Ile Gln Ile  Asn Phe Glu 
    1055                 1060                 1065             


Ile Ser  Asn Asp Lys Asn Glu  Val Phe Lys Tyr Lys  Ile Lys Asn 
    1070                 1075                 1080             


Arg Leu  Tyr Ser Lys Lys Gly  Lys Met Leu Gly Lys  Asn Asn Lys 
    1085                 1090                 1095             


Phe Glu  Ile Leu Glu Asn Glu  Phe Leu Glu Asn Val  Lys Thr Leu 
    1100                 1105                 1110             


Leu Glu  Tyr Ser Lys 
    1115             


<210>  98
<211>  985
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  98

Leu Glu Lys Asn Lys Ala His Phe Lys Lys Glu Ser Val Asn Asn Thr 
1               5                   10                  15      


Thr Asp Arg Val Lys Gly Asn Asn Lys Lys Ser Leu Phe Tyr Glu Tyr 
            20                  25                  30          


Tyr Arg Asn Ser Ser Lys His Gln Glu Tyr Val Asn Asn Ile Phe Glu 
        35                  40                  45              


Ala Phe Asp Lys Leu Tyr Ser Asn Ser His Glu Asp Ile Asn Asn Leu 
    50                  55                  60                  


Phe Leu Glu Ile Thr Lys Gly Ser Asn Asn Arg Asn Ile Arg Lys Ile 
65                  70                  75                  80  


Arg Glu Val Tyr His Glu Ile Leu Asn Lys Asn Lys Thr Glu Phe Glu 
                85                  90                  95      


Glu Glu Leu Tyr Lys Lys Ile Gln Asp Ser Ile Ser Asn Phe Asp Lys 
            100                 105                 110         


Leu Leu Glu Ile Glu Pro Glu Ile Lys Glu Leu Thr Lys Ser Gln Ile 
        115                 120                 125             


Phe Tyr Lys Tyr Tyr Ile Asp Lys Val Asn Leu Asn Glu Ile Asn Ile 
    130                 135                 140                 


Lys Tyr Cys Phe Cys His Leu Val Glu Ile Glu Val Asn Gln Leu Leu 
145                 150                 155                 160 


Lys Asn Tyr Val Tyr Ser Lys Arg Asn Val Asn Lys Glu Lys Leu Glu 
                165                 170                 175     


Asn Ile Phe Glu Tyr Cys Lys Leu Lys Asn Leu Ile Lys Asn Lys Leu 
            180                 185                 190         


Val Asn Lys Leu Asn Ser Tyr Ile Arg Asn Cys Gly Lys Tyr Asn Gly 
        195                 200                 205             


Tyr Ile Asn Asn Asn Asn Ile Ile Asp Ser Lys Lys Ile Ser Glu Ile 
    210                 215                 220                 


Arg Ile Lys Glu Ala Phe Leu Arg Ser Ile Ile Gly Val Ser Ser Ser 
225                 230                 235                 240 


Ala Tyr Phe Ser Leu Arg Asn Ile Leu Asn Thr Asp Asn Thr Gln Asp 
                245                 250                 255     


Ile Thr Asn Lys Val Lys Gly Glu Val Asp Lys Leu Tyr Gln Glu Asn 
            260                 265                 270         


Lys Lys Ile Glu Leu Glu Glu Arg Leu Lys Leu Phe Phe Gly Asn His 
        275                 280                 285             


Phe Asp Ile Asn Asn Gln Gln Glu Ile Glu Asp Phe Leu Met Asn Ile 
    290                 295                 300                 


Asp Lys Ile Ile Ser Ser Ile Arg His Glu Ile Ile His Phe Lys Met 
305                 310                 315                 320 


Glu Ala Asn Ala Gln Asn Ile Phe Asp Phe Asn Asn Ile Asn Leu Gly 
                325                 330                 335     


Asn Lys Ala Lys Asn Ile Phe Ser Asn Glu Ile Asn Glu Glu Lys Ile 
            340                 345                 350         


Lys Phe Lys Ile Phe Lys Gln Leu Asn Ser Ala Asn Val Phe Asp Tyr 
        355                 360                 365             


Leu Ser Asn Lys Asp Ile Thr Glu Tyr Ile Gly Lys Ala Val Phe Ser 
    370                 375                 380                 


Phe Thr Asn Arg Asn Ile Pro Phe Val Pro Ser Phe Thr Lys Ile Tyr 
385                 390                 395                 400 


Asn Arg Val Gln Asp Leu Ala Asn Ser Leu Glu Ile Lys Glu Trp Lys 
                405                 410                 415     


Ile Pro Gly Glu Ser Glu Gly Lys Asp Ala Gln Ile Tyr Leu Leu Lys 
            420                 425                 430         


Asn Ile Tyr Tyr Gly Lys Phe Leu Asp Glu Phe Leu Asn Glu Lys Asn 
        435                 440                 445             


Gly Lys Phe Ile Arg Met Lys Asp Glu Val Ile Glu Leu Asn Arg Asn 
    450                 455                 460                 


Gln Asn Lys Lys Thr Gly Phe Tyr Lys Leu Glu Lys Phe Glu Lys Ile 
465                 470                 475                 480 


Glu Glu Thr Asn Pro Lys Lys Tyr Leu Glu Ile Ile Gln Ser Leu Tyr 
                485                 490                 495     


Met Ile Asn Ile Glu Glu Ile Asp Ser Glu Glu Lys Asn Ile Phe Leu 
            500                 505                 510         


Asp Phe Ile Gln Lys Ile Phe Leu Lys Gly Phe Phe Glu Phe Ile Lys 
        515                 520                 525             


Asn Asn Tyr Asn Tyr Leu Leu Glu Leu Lys Lys Val Gln Asp Lys Lys 
    530                 535                 540                 


Asn Val Phe Asp Lys Glu Met Ser Lys Tyr Thr Ala Gly Glu Lys Thr 
545                 550                 555                 560 


Leu Gly Asp Met Glu Glu Ile Asn Glu Ile Thr Gln Lys Ile Lys Val 
                565                 570                 575     


Ala Glu Ile Asp Lys Ile Leu Asn Gln Thr Asp Lys Ile Asn Cys Phe 
            580                 585                 590         


Tyr Leu Leu Leu Lys Leu Leu Asn Tyr Lys Glu Ile Thr Glu Leu Lys 
        595                 600                 605             


Gly Asn Leu Glu Lys Tyr Gln Ile Leu Ser Asn Thr Asn Ile Tyr Lys 
    610                 615                 620                 


Lys Glu Leu Ile Leu Leu Asn Ile Val Asn Leu Asp Asn Asn Lys Val 
625                 630                 635                 640 


Lys Ile Glu Asp Phe Glu Ile Ser Ala Glu Glu Ile Gly Lys Phe Ile 
                645                 650                 655     


Glu Lys Ile Ser Arg Asn Lys Lys Ile Lys Thr Phe Glu Glu Leu Arg 
            660                 665                 670         


Asn Phe Glu Lys Arg Glu Asn Thr Gly Glu Tyr Tyr Asn Val Tyr Ser 
        675                 680                 685             


Asp Asp Lys Asn Ile Lys Asn Met Arg Asn Leu Tyr Asn Ile Lys Lys 
    690                 695                 700                 


Tyr Gly Met Leu Asp Leu Leu Glu Arg Ile Ser Glu Lys Ala Asn Tyr 
705                 710                 715                 720 


Phe Ile Lys Lys Glu Asp Leu Lys Glu Tyr Ser Glu Leu Arg Lys Gln 
                725                 730                 735     


Leu Glu Asp Glu Lys Thr Asp Phe Tyr Lys Ile Gln Lys Asp Leu His 
            740                 745                 750         


Tyr Glu Tyr Gln Lys Lys Tyr Lys Asn Phe Ser Lys Lys Asn Asn Thr 
        755                 760                 765             


Glu Asp Tyr Glu Lys Tyr Lys Glu Ser Ile Glu Asn Ile Glu Lys Tyr 
    770                 775                 780                 


Val His Leu Lys Asn Lys Ile Glu Phe Asn Glu Leu Asn Leu Leu Gln 
785                 790                 795                 800 


Ser Leu Leu Leu Lys Ile Leu His Arg Leu Val Gly Phe Thr Ser Ile 
                805                 810                 815     


Trp Glu Arg Asp Leu Arg Phe Arg Leu Ile Gly Glu Phe Pro Asp Glu 
            820                 825                 830         


Leu Asp Val Glu Asp Ile Phe Asp His Arg Lys Ile Tyr Arg Arg Thr 
        835                 840                 845             


Arg Gly Gln Ile Cys Lys Lys Tyr Asp Arg Phe Ile Asn Thr His Thr 
    850                 855                 860                 


Glu Tyr Lys Asn Asn Asn Lys Met Lys Asn Ile Lys Phe Tyr Asp Asn 
865                 870                 875                 880 


Asn Pro Val Arg Asn Tyr Ile Ala His Phe Asn Tyr Leu Pro Asn Pro 
                885                 890                 895     


Lys Tyr Ser Ile Leu Lys Met Leu Lys Lys Leu Arg Glu Leu Leu Asp 
            900                 905                 910         


Tyr Asp Arg Lys Leu Lys Asn Ala Val Met Lys Ser Ile Lys Asp Ile 
        915                 920                 925             


Leu Glu Glu Tyr Gly Phe Glu Ala Glu Phe Ile Ile Asn Pro Asp Lys 
    930                 935                 940                 


Glu Ile Ile Leu Asn Ser Val Lys Ser Ile Lys Ile Ile His Leu Gly 
945                 950                 955                 960 


Lys Asn Asp Leu Lys Ser His Arg Asn Ser Lys Asp Leu Cys Lys Leu 
                965                 970                 975     


Val Lys Ala Met Phe Glu Tyr Ser Lys 
            980                 985 


<210>  99
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  99

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Asn Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys His Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Asn Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Glu 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Val Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Thr Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Lys Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Glu  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  100
<211>  1186
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  100

Met Lys Val Thr Lys Ile Asp Gly Leu Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ile Glu Asp Ala Ser Gln Lys Asn Glu Thr 
            20                  25                  30          


Leu Glu Arg Leu Glu Lys Leu Lys Glu Ile Lys Leu Gly Asn Tyr Ile 
        35                  40                  45              


Lys Asn Pro Asp Lys Thr Lys Asp Lys Asp Asn Lys Lys Arg Arg Lys 
    50                  55                  60                  


Gly Leu Lys Glu Tyr Phe Ser Glu Ile Thr Leu Arg Lys Glu Asn Glu 
65                  70                  75                  80  


Lys Tyr Val Leu Leu Lys Gly Lys Lys Leu Lys Lys Ile Asn Asn Asp 
                85                  90                  95      


Ile Lys Asp Thr Asp Ile Lys Val Lys Tyr Lys Lys Glu Glu Val Phe 
            100                 105                 110         


Asp Val Leu Lys Lys Ile Leu Lys Leu Asn Leu Leu Ala Asn Asp Val 
        115                 120                 125             


Glu Glu Lys Ile Gln Phe Asp Ser Ile Lys Leu Lys Asn Val Phe Gly 
    130                 135                 140                 


Lys Asp Phe Val Lys Lys Glu Leu Gln Ile Lys Ser Ile Glu Glu Ser 
145                 150                 155                 160 


Leu Glu Lys Asn Lys Ala Asp Tyr Arg Lys Glu Phe Ile Glu Ile Glu 
                165                 170                 175     


Asn Asp Lys Tyr Gly Asn Val Lys Gly Glu Asn Lys Lys Asn Arg Ile 
            180                 185                 190         


Tyr Glu Tyr Tyr Lys Lys Ser Glu Thr His Glu Lys Phe Arg Lys Asn 
        195                 200                 205             


Ile Ile Glu Ala Phe Glu Lys Leu Tyr Lys Lys Asp Asp Ile Glu Lys 
    210                 215                 220                 


Leu Tyr Thr Gln Ile Ile Glu Ile Ser Lys Lys Met His Leu Lys Ser 
225                 230                 235                 240 


Lys Val Arg Glu Leu Tyr Lys Asn Val Ile Ile Lys Arg Ser Cys Asp 
                245                 250                 255     


Asp Phe Ser Lys Lys Asn Lys Glu Gly Ile Ser Val Leu Tyr Ser Gln 
            260                 265                 270         


Ile Met Asn Ser Val Lys Lys Asn Glu Lys Phe Val Lys Phe Val Lys 
        275                 280                 285             


Asn Ile Glu Leu Lys Asp Leu Thr Lys Ser Gln Ile Phe Tyr Lys Tyr 
    290                 295                 300                 


Phe Leu Glu Asn Glu Glu Leu Asn Asp Glu Asn Ile Lys Asn Ile Phe 
305                 310                 315                 320 


Cys Tyr Phe Val Glu Ile Glu Val Ser Asp Leu Leu Lys Gly Asn Val 
                325                 330                 335     


Tyr Lys Val Ser Lys Ile Tyr Glu Asn Lys Ile Lys Asn Ile Phe Glu 
            340                 345                 350         


Tyr Asn Lys Leu Lys Lys Leu Val Ile Asn Lys Leu Glu Asn Lys Leu 
        355                 360                 365             


Asn Asn Tyr Val Arg Asn Cys Gly Lys Tyr Asn Tyr His Met Glu Asn 
    370                 375                 380                 


Gly Asp Ile Ala Thr Ser Asp Ile Asn Met Arg Asn Arg Gln Thr Glu 
385                 390                 395                 400 


Ala Phe Leu Arg Ser Met Ile Gly Val Ser Ser Phe Gly Tyr Phe Ser 
                405                 410                 415     


Leu Arg Asn Ile Leu Gly Val Asn Asp Asp Asp Phe Tyr Glu Ile Glu 
            420                 425                 430         


Glu Asp Leu Thr Glu Glu Glu Arg Lys Asn Glu Ser Asn Val Leu Lys 
        435                 440                 445             


Lys Ala Lys Glu Asp Ile Thr Ser Lys Ser Ile Phe Glu Lys Val Val 
    450                 455                 460                 


Asp Lys Ser Phe Glu Lys Lys Gly Ile His Ser Ile Arg Glu Asn Val 
465                 470                 475                 480 


Lys Met Phe Tyr Gly Asp Ser Phe Asp Lys Ala Asn Glu Asp Glu Leu 
                485                 490                 495     


Lys Gln Phe Phe Val Asn Met Leu Asn Ala Ile Thr Ser Ile Arg His 
            500                 505                 510         


Arg Val Val His Tyr Asn Met Asn Thr Asn Ser Glu Asn Ile Phe Asn 
        515                 520                 525             


Phe Ser Asp Ile Glu Val Ser Arg Leu Leu Lys Ser Ile Phe Glu Lys 
    530                 535                 540                 


Glu Thr Asp Lys Arg Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn 
545                 550                 555                 560 


Ser Ala Gly Val Phe Asp Tyr Trp Glu Asn Trp Lys Ile Lys Lys Tyr 
                565                 570                 575     


Leu Glu Asn Met Lys Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val 
            580                 585                 590         


Pro Ser Phe Thr Lys Leu Tyr Asn Arg Ile Asp Asn Leu Lys Gly Ser 
        595                 600                 605             


Asn Ala Leu Asn Leu Gly Tyr Ile Asn Ile Pro Lys Arg Lys Glu Ala 
    610                 615                 620                 


Arg Asp Ser Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Lys Phe 
625                 630                 635                 640 


Val Glu Glu Phe Ile Lys Asn Asn Asp Asn Phe Glu Lys Ile Phe Arg 
                645                 650                 655     


Glu Ile Ile Glu Ile Asn Lys Asn Ala Gly Thr Asn Lys Gln Thr Asn 
            660                 665                 670         


Phe Tyr Lys Leu Glu Lys Phe Glu Lys Leu Lys Ala Asn Thr Pro Thr 
        675                 680                 685             


Glu Tyr Leu Glu Lys Leu Gln Ser Leu His Lys Ile Asn Tyr Asn Arg 
    690                 695                 700                 


Glu Lys Ile Glu Glu Asp Lys Asp Ile Tyr Val Asp Phe Val Gln Lys 
705                 710                 715                 720 


Ile Phe Leu Lys Gly Phe Ile Ser Tyr Leu Gln Lys Ser Asn Ser Leu 
                725                 730                 735     


Lys Pro Leu Asn Leu Leu Asn Leu Lys Lys Asp Glu Val Ile Asn Ser 
            740                 745                 750         


Glu Lys Ser Phe Tyr Asp Glu Lys Leu Lys Gln Trp Glu Asn Asn Gly 
        755                 760                 765             


Ser Asn Leu Ser Glu Met Pro Lys Glu Ile Tyr Lys Tyr Ile Lys Glu 
    770                 775                 780                 


Ile Lys Ile Asn Lys Thr Asn Tyr Ser Asp Arg Met Ser Ile Phe Tyr 
785                 790                 795                 800 


Leu Leu Leu Lys Leu Ile Asp His Lys Glu Leu Thr Asn Leu Arg Gly 
                805                 810                 815     


Asn Leu Glu Lys Tyr Glu Ser Met Asn Lys Asn Lys Ile Tyr Ser Glu 
            820                 825                 830         


Glu Leu Asn Ile Val Asn Leu Val Ser Leu Asp Asn Asn Lys Val Arg 
        835                 840                 845             


Thr Asn Phe Ser Val Glu Ala Glu Asp Ile Gly Lys Phe Leu Lys Thr 
    850                 855                 860                 


Glu Thr Ser Ile Lys Asn Ile Asn Gln Leu Asn Asn Phe Ser Gly Ile 
865                 870                 875                 880 


Phe Ala Asp Gly Glu Asn Val Ile Lys His Arg Ser Phe Tyr Asn Ile 
                885                 890                 895     


Lys Lys Tyr Gly Ile Leu Asp Leu Leu Glu Lys Ile Val Ala Lys Ala 
            900                 905                 910         


Asp Leu Lys Ile Ala Lys Glu Glu Ile Lys Lys Tyr Glu Asn Leu Gln 
        915                 920                 925             


Lys Glu Leu Glu Lys Asn Asp Phe Tyr Lys Ile Gln Glu Lys Ile His 
    930                 935                 940                 


Arg Lys Tyr Asn Gln Lys Pro Asn Leu Ile Ser Arg Thr Glu Asn Lys 
945                 950                 955                 960 


Lys Asp Phe Asn Asp Tyr Lys Lys Ala Ile Glu Asn Ile Gln Asn Tyr 
                965                 970                 975     


Thr Gln Leu Lys Asn Lys Ile Glu Phe Asn Asp Leu Asn Leu Leu Gln 
            980                 985                 990         


Gly Leu Leu Phe Arg Ile Leu His  Arg Leu Thr Gly Tyr  Thr Ser Leu 
        995                 1000                 1005             


Trp Glu  Arg Asp Leu Gln Phe  Lys Leu Lys Gly Glu  Phe Pro Glu 
    1010                 1015                 1020             


Asp Lys  Tyr Ile Asp Glu Ile  Phe Asn Ser Asp Arg  Asn Asn Asn 
    1025                 1030                 1035             


Gln Lys  Tyr Lys Ser Gly Gly  Ile Ala Tyr Lys Tyr  Val Asp Phe 
    1040                 1045                 1050             


Leu Ile  Glu Lys Glu Glu Gly  Lys Arg Ala Gly Lys  Asn Lys Val 
    1055                 1060                 1065             


Lys Lys  Arg Ser Glu Arg Glu  Arg Ser Phe Ile Ile  Arg Asn Tyr 
    1070                 1075                 1080             


Ile Ala  His Phe Asn Tyr Ile  Pro Asp Ala Glu Lys  Ser Ile Leu 
    1085                 1090                 1095             


Glu Ile  Leu Glu Glu Leu Arg  Glu Leu Leu Lys Tyr  Asp Arg Lys 
    1100                 1105                 1110             


Leu Lys  Asn Ala Val Met Lys  Ser Ile Lys Asp Ile  Phe Lys Glu 
    1115                 1120                 1125             


Tyr Gly  Phe Ile Ile Glu Phe  Gly Ile Ser His Glu  Ser Asn Ser 
    1130                 1135                 1140             


Lys Lys  Ile Lys Val Leu Asn  Val Glu Ser Gly Lys  Ile Lys His 
    1145                 1150                 1155             


Leu Lys  Asn Asn Gly Leu Val  Thr Thr Arg Asn Ser  Lys Asp Leu 
    1160                 1165                 1170             


Cys Lys  Leu Val Lys Val Met  Leu Glu Tyr Lys Lys  Ser 
    1175                 1180                 1185     


<210>  101
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  101

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Gly Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  102
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  102

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Thr Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  103
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  103

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  104
<211>  1373
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  104

Met Ala Lys His Leu Arg Pro Ile Gly Glu Ser Tyr Thr Asp Phe Leu 
1               5                   10                  15      


Asp Glu Thr Glu Phe Val Arg Leu Gly Arg Gly Leu His Arg Gly His 
            20                  25                  30          


His Gly Val Gln Ile Pro Pro Thr Glu Leu Pro Ser Tyr Leu Ala Glu 
        35                  40                  45              


Tyr Arg Lys Ala Leu Met Arg Gln Val Val Ala Val Leu Asp Lys Val 
    50                  55                  60                  


Val Gly Lys Arg Arg Arg Leu Ser Gly Met His Pro Glu Ala Tyr Arg 
65                  70                  75                  80  


Asp Arg Val His Leu Ala Glu Ala Leu Trp Val Arg Leu Val Ala Arg 
                85                  90                  95      


Val Lys Glu Ile Gly Thr Pro Pro Asp Pro Ser Glu Leu Leu Asp Leu 
            100                 105                 110         


Arg Arg Met Trp Asn Ala Lys Ala His Pro Tyr Ala Glu Tyr Asp Val 
        115                 120                 125             


Val Pro Arg Ala Pro Leu Asn Asp Gly Asn Gly Gln Lys Ile Leu Glu 
    130                 135                 140                 


Cys Arg Glu Val Asp Asp Pro Lys Ile Glu Arg Ser Asp Phe Glu Gly 
145                 150                 155                 160 


Arg Trp His Gly Arg Phe Trp Gln Ser Glu Pro Gly Pro Val Asp Tyr 
                165                 170                 175     


Asn Ala Ile Ala Asp Arg Ile Phe Ala His Leu Phe Asp Gln Glu Ala 
            180                 185                 190         


Val Ile Gly Gly Gly Pro Arg Arg Glu Gly Asn Val Thr Val Pro Asp 
        195                 200                 205             


Glu Asp Ile Asn Gly Gln Pro Gly Pro Ala Thr Gly Lys Gly Leu Ile 
    210                 215                 220                 


Ile Ala Arg Gly Gln Ser Ile Val Lys Ser Ala Ser Asp Pro Arg Arg 
225                 230                 235                 240 


Ser Ser Lys Lys Val Gln Arg Thr Trp Asp Lys Ala Val Glu Arg Arg 
                245                 250                 255     


Tyr Phe Gly Asp Asp Gly Lys Gly Gly Ser Asp Ile Ala Lys Ala Ile 
            260                 265                 270         


Tyr Glu Glu Leu Gly Asp Pro Ala Thr Leu Ala Asp Pro Ile Tyr Ala 
        275                 280                 285             


Ser Trp Phe Gly Ser Arg Leu Tyr Asp His Phe Gly Ser Phe Lys Asn 
    290                 295                 300                 


Ser Leu Pro Leu Glu Leu Lys Asp Pro Phe Lys Glu Gln Ile Trp Ala 
305                 310                 315                 320 


Leu His Asn Ser Val Arg Gln Phe Tyr Gln Arg Met Ala Lys Ser Asp 
                325                 330                 335     


Arg Phe Arg Leu Ala Leu Gln Asn Ala Arg Ser Glu Val Pro Asp Arg 
            340                 345                 350         


Ser Glu Leu Leu Ala Leu Leu Pro Lys Asp His Asp His Leu Leu Leu 
        355                 360                 365             


Val Leu Gly Gly Lys Lys Lys Asn Ala Glu Met Ser Glu Leu Ile Arg 
    370                 375                 380                 


Leu Gly Lys Leu Phe Val His Ala Ser Asp Val Leu His Asp Phe Asp 
385                 390                 395                 400 


Ala Asn Asp Ala Ala Ala Leu Asp Ala Phe Lys Arg Arg Met Ser Phe 
                405                 410                 415     


Leu Ala Thr Ser Ile Gly Gln Ser Glu Ile Lys Gln Thr Glu Thr Phe 
            420                 425                 430         


Ala Arg Thr Trp Arg Gly Ala Val Gly Leu Thr Leu Arg Thr Val Lys 
        435                 440                 445             


Gly Leu Ala Asp Pro Arg Gly Ile Ile Gly Thr Pro Asp Asn Arg Asp 
    450                 455                 460                 


Leu Gly Thr Ala Gly Pro Met Lys Asp Ala Phe Asn Lys Phe Asp Gln 
465                 470                 475                 480 


Pro His Phe Gln Gln His Met Thr Ile Ile Phe Gly Asn Lys Glu Leu 
                485                 490                 495     


Gln Ala Glu Gly Asn Pro Thr Arg Ser Ser Val Phe Thr Ala Asn Gly 
            500                 505                 510         


Asp Lys Asp His Gln Ala Glu Leu Leu Trp Gly Phe Leu Cys Val Val 
        515                 520                 525             


Arg Ser Val Arg Asn Arg Thr Asn His Tyr Asn Val Arg Arg Ala Leu 
    530                 535                 540                 


Leu Arg Leu Leu Asp Glu Gly Ile Val Ser Pro Met Pro Ser Asp Pro 
545                 550                 555                 560 


Lys Lys Glu Arg Val Glu Asn Arg Asn Leu Cys Thr Val Ser Pro Thr 
                565                 570                 575     


Ala Leu Glu Ala Phe Arg Arg Leu Leu Asn Phe Asp Leu Ala Ile Gln 
            580                 585                 590         


Lys Glu Ala Val Arg Thr Ala Leu Glu Gln Ala Lys Ala Ser Glu Phe 
        595                 600                 605             


Val Glu Glu Gly Lys Leu Arg Gly Leu Val Ser Glu Leu Ala Gly Thr 
    610                 615                 620                 


Glu Asp Met Pro Ala Leu His Ile Pro Arg Phe Ser Ala Val Met Asp 
625                 630                 635                 640 


Lys Val Arg Arg Leu Ala Asp Asn Arg Asp Val Gly Leu Asp Pro Ile 
                645                 650                 655     


Leu Ser Thr Leu Gln Arg Ser Leu Pro Pro Thr Asp Lys Gln Ala Glu 
            660                 665                 670         


Ser Asp Ala Ala Arg Cys Arg Tyr Arg Leu Leu Leu Glu Leu Tyr Lys 
        675                 680                 685             


Ser Gly Phe Arg Ser Trp Phe Ser Gly Ile Gln Ser Asn Glu Glu Asn 
    690                 695                 700                 


Asn Arg Glu Ile Cys His Trp Ala Val Lys Gln Val Gly Arg Ala Lys 
705                 710                 715                 720 


Asp Ala Arg Lys Ser Glu Tyr Asp Lys Lys Thr Lys Arg His Tyr Arg 
                725                 730                 735     


Ser Pro Asn Ser Leu Ile Asp Asp Leu Gly Leu Asp Lys Phe Asp Asp 
            740                 745                 750         


Leu Thr Asp Leu Leu Glu Ala Leu Ala Ser Gln Ser Thr Arg Glu His 
        755                 760                 765             


Asp Gln Asn Leu Lys Tyr Val Pro Asp Ala Arg Val Gln Ser Gln Met 
    770                 775                 780                 


Ser Asn Arg Ile Glu Glu Phe Arg Gln Glu Leu Phe Ala His Ile Phe 
785                 790                 795                 800 


Thr Lys Tyr Leu Asp Thr His Asp Phe Gly Trp Ile Gly Ala Ile Glu 
                805                 810                 815     


Val Arg Arg Glu Ala Cys Asp Leu Ala Asp Val Val Ser Ala Phe Glu 
            820                 825                 830         


Val Arg Asp Gln Lys Phe Asp Ala Asp Trp His Ser Gln Phe Tyr Ala 
        835                 840                 845             


Trp Leu Tyr Met Val Pro Pro Ile Glu Ala Ser Arg Leu Arg His Gln 
    850                 855                 860                 


Met Arg Lys Ser Ala Val Met Asp Asp Lys Trp Ser Thr Thr Leu Glu 
865                 870                 875                 880 


Leu Thr Ser Gly Asp Arg Lys Thr Arg Asp Asp His Ala Gln Asp Val 
                885                 890                 895     


Leu Ala Asp Met Asp Arg Leu Phe Ser Leu Tyr Thr Lys Val Gln Ala 
            900                 905                 910         


Ala Gly Phe Asn Gly Gln Glu His Glu Ser Ala Leu Gly Ser Lys Ser 
        915                 920                 925             


Leu Phe Tyr Glu Asp Gly Asn Gln Phe Asp Glu Val Tyr Ser Pro Asp 
    930                 935                 940                 


Thr Glu Thr His Asn Lys Thr Phe Pro Gly Thr Arg Arg Gly Leu Arg 
945                 950                 955                 960 


Gln Leu Val Arg Tyr Ala His Leu Pro Ala Leu Glu Gly Val Phe Lys 
                965                 970                 975     


Lys His Arg Ile Thr Lys Ala Glu Val Glu Thr Phe Val Ala Leu Tyr 
            980                 985                 990         


Asp Glu Asn Arg Arg Asp Pro Gly  Ser Val Ala His Met  Leu Arg Arg 
        995                 1000                 1005             


Glu Lys  Leu Arg Thr Glu Ile  Leu Arg Ser Ile His  Asp Gly Pro 
    1010                 1015                 1020             


Lys Pro  Lys Asp Lys Asp Phe  Trp Pro Lys Leu Glu  Ala Lys Cys 
    1025                 1030                 1035             


Leu Glu  Tyr Arg Thr Val Ala  Thr Glu Thr Ala Ile  Tyr Asn Phe 
    1040                 1045                 1050             


Gln Ala  Asn Ala Ala Arg Leu  Asn Asp His Ala Arg  Leu His Gln 
    1055                 1060                 1065             


Ile Val  Met Arg Val Val Ala  Arg Leu Thr Asp Tyr  Ala Leu Ile 
    1070                 1075                 1080             


Trp Glu  Arg Asp Arg Leu Phe  Ala Phe Val Gly Met  Leu Tyr Arg 
    1085                 1090                 1095             


Gln Thr  Gly Gly Thr Gly Ile  Asn Pro Ala Met Arg  His Ala Glu 
    1100                 1105                 1110             


Lys Thr  Asn Ala Pro Pro Arg  Ile Gly Ile Leu Val  Ser Asp Ser 
    1115                 1120                 1125             


Ala Leu  Ala Lys Lys Leu Asn  Ser Asn Ser Ala Glu  Val Phe Ile 
    1130                 1135                 1140             


Pro Tyr  Leu Asp Thr Glu Thr  Gly Phe Asp Ala Pro  Arg Phe Asp 
    1145                 1150                 1155             


Asp Leu  Cys Thr Leu Leu Ser  His Glu His Ala Lys  Glu Phe Arg 
    1160                 1165                 1170             


Phe His  Phe Leu Glu Val Gly  Glu Glu Asn Ser Lys  Asp Glu Ala 
    1175                 1180                 1185             


Arg Arg  Leu Asn Glu Glu Thr  Met Gly His Arg Lys  Arg Pro Ala 
    1190                 1195                 1200             


Phe Lys  Arg Gly Thr Arg Arg  Gln Gly Ile Arg Asn  Asp Leu Ala 
    1205                 1210                 1215             


His His  Asn Val Leu Asp Leu  Ala Gly Gly Ala Gly  Pro Asn Leu 
    1220                 1225                 1230             


Thr Tyr  Val Val Asn Ala Val  Arg Ser Leu Leu Ser  Tyr Asp Arg 
    1235                 1240                 1245             


Lys Leu  Lys Asn Ala Val Pro  Lys Ser Ile Lys Arg  Ile Leu Gly 
    1250                 1255                 1260             


Glu Glu  Gly Leu Ile Ile Glu  Trp Gln Met Asn Tyr  Asp Arg Leu 
    1265                 1270                 1275             


Lys Lys  Pro Thr Val Tyr Pro  Asn Val Glu Thr His  Leu Thr Met 
    1280                 1285                 1290             


Val Pro  Pro Arg His Met Thr  Ala Pro Val Ser Phe  Thr Leu Pro 
    1295                 1300                 1305             


Arg Ala  Ser Val Arg Leu Ala  Ser Met Val Lys Ala  Val Phe Asp 
    1310                 1315                 1320             


Phe Gly  Ser Ser Gly Tyr Gly  Glu Glu Arg Met Ile  Gly Gly Arg 
    1325                 1330                 1335             


Thr Ala  Lys Gln Ala Val Tyr  Pro Asp Asp Phe Thr  Arg Arg Phe 
    1340                 1345                 1350             


Pro Gln  Thr Pro Met Gly Leu  Lys Gln Ala Thr Arg  Leu Val Phe 
    1355                 1360                 1365             


Ala Ser  Glu Asn Ser 
    1370             


<210>  105
<211>  1287
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  105

Met Arg Ile Gly Lys Val Gln Gly Arg Thr Phe Thr Gly Phe Asp Asn 
1               5                   10                  15      


Ala Arg Gly Lys Thr Leu Arg Arg Arg Leu Leu Thr Arg Pro Asp Asn 
            20                  25                  30          


Glu Ala Arg Ser Leu Ser Glu His Leu Ala His Asp Pro Lys Ala Leu 
        35                  40                  45              


Ile Gly Gln Ala Ile Ser Arg Ile Asp Thr Ile Tyr Gln Lys Pro Lys 
    50                  55                  60                  


Thr Gly Lys Pro Thr Pro Glu Gln Phe Gly His Arg Asp Thr Leu Gly 
65                  70                  75                  80  


Trp Ala Tyr Trp Lys Leu Leu Val Ala Ser Tyr Pro Glu Val Glu Gly 
                85                  90                  95      


His Arg Asp Leu Phe Val Arg Arg Leu His Pro Tyr Gly Asp Thr Pro 
            100                 105                 110         


Pro Lys Ser His Gly Gln Lys Glu Gly Glu His Gln Lys Gly Gly Lys 
        115                 120                 125             


Pro Gln Leu Glu Gly Arg Trp His Gly Val Met Ala Gln His Gly Lys 
    130                 135                 140                 


Asn Pro Asp Gln Ile Ala Ala Arg Leu Phe Asp His Leu His Asn Ser 
145                 150                 155                 160 


Glu Leu Arg Phe Gly Gly Thr Ala Ser Gly Glu Pro Arg Thr Arg Pro 
                165                 170                 175     


Gly Lys Glu Ala Thr Pro Thr Gly Leu Ile Gly Ala Arg Ala Lys Thr 
            180                 185                 190         


Ile Glu His Ser Val Leu Pro Arg Asp Ala Lys Arg Phe Val Ala Glu 
        195                 200                 205             


Trp Arg Gly Glu Asp Gln Glu Arg Tyr Ala Gly Ala Arg Asp Ile Ala 
    210                 215                 220                 


Ala Ala Ile Ser Ala Gly Leu Asn Asp Lys Asp Gln Lys Ser Gly Ser 
225                 230                 235                 240 


Gly Arg Lys Ser Ala Val Ile Gly Lys Leu Leu Ser Asp His Leu Glu 
                245                 250                 255     


Thr Leu Thr Gly Asn Arg Lys Cys Arg Phe Asp Pro Lys Ser Thr Ala 
            260                 265                 270         


Glu Thr Leu Glu Leu Arg Asp Gly Glu Ser Val Asp Asp Arg Arg Arg 
        275                 280                 285             


Ile Leu Glu Leu His Ala Glu Val Lys Ala Thr Tyr Lys Arg Met Ala 
    290                 295                 300                 


Ala Trp Lys Pro Ala Lys Leu Pro Arg Asn Ser Asp Glu Leu Phe Arg 
305                 310                 315                 320 


Leu Val Arg Gln Gln Ala Asp Asn Arg Ile Leu Asn His Leu Val Arg 
                325                 330                 335     


Val Gly Arg Ile Ser Val Tyr Ser Glu Gln Ser Asp Ala Leu Ser Glu 
            340                 345                 350         


Ser Gln Phe Trp Thr Ser Gly Gly Gln Thr Gln Ile Lys Glu Ser Glu 
        355                 360                 365             


Val Phe Ala Arg Leu Trp Ile Gly Ala Ile Ser Arg Ala Ser Tyr Ser 
    370                 375                 380                 


Met Lys Ala Trp Leu Glu Pro Glu Gly Thr Val Phe Asn Pro Ser Ile 
385                 390                 395                 400 


Asn Asp Phe Asp Val Thr Ser Ser His Asn Thr Asn Arg Ile Leu Glu 
                405                 410                 415     


Asp Ser Gly Arg Leu Ser Asn Ala Met Ala Arg Arg Ala Ile Tyr Phe 
            420                 425                 430         


Gly Glu Thr Pro Glu Phe Asp Ala Leu Gly Glu Glu Asp Gln Arg Val 
        435                 440                 445             


Leu Val Lys Lys Cys Leu Asp Ala Leu Ser Ala Cys Arg Asn Arg Thr 
    450                 455                 460                 


Phe His His Gly Gln Arg Ala Lys Phe Leu Lys Glu Val Arg Lys Gly 
465                 470                 475                 480 


Leu Lys Glu Lys Glu Ala Asp Ser Ala Gly Pro Ala Ala Trp Glu Gly 
                485                 490                 495     


Ile Arg Glu Val Ile Gln Ala Asp Ala Arg Asn Leu Gly Ala Arg Leu 
            500                 505                 510         


Leu Gln Asp Leu Thr Gly Ala Lys Val His Ser Phe Ala Thr Asp Pro 
        515                 520                 525             


Glu Phe Arg His Leu Tyr Glu Ser Val Ala Ala Thr Leu Thr Ala Gly 
    530                 535                 540                 


Gly Glu Leu Glu Ala Ala Leu Pro Arg Leu Lys Asn Val Leu Lys Arg 
545                 550                 555                 560 


Ala Glu Gly Val Arg Cys Tyr Leu Asp Thr Pro Ser Gln Arg Arg Glu 
                565                 570                 575     


Gly Asp Glu Ser Leu Ile Ala Arg Leu Pro Val Ala Pro Val Pro Arg 
            580                 585                 590         


Glu Leu Asp Asp Ala Ala Thr Lys Ala Arg His Ser Ala Leu Leu Arg 
        595                 600                 605             


Leu Tyr Asp Gly Pro Phe Arg Pro Trp Ala Thr Glu Leu Arg Gly Glu 
    610                 615                 620                 


Arg Leu Ser Asp Tyr Ala Ala Arg Ala Lys Arg Leu Ala Thr Arg Leu 
625                 630                 635                 640 


Ala Lys Ser Thr Asn Thr Ala Ser Pro Tyr Pro Asp Ser Val Glu Gly 
                645                 650                 655     


Arg Ser Val Arg Leu Arg Asp Pro Ile Thr Ala Asp Thr Ala Pro Glu 
            660                 665                 670         


Thr Leu Lys Thr Tyr Leu Ser Ala Leu Thr Ala Glu Thr Ala Thr Glu 
        675                 680                 685             


Phe Arg Val Gln Lys Gly Tyr Glu Ser Asp Gly Glu Lys Ala Lys Glu 
    690                 695                 700                 


Gln Ala Glu Phe Ile Glu Asp Phe Arg Arg Asp Met Ile Ala Leu Ala 
705                 710                 715                 720 


Phe Gln Asp Phe Ile Arg Asp His Gly Phe Ala Trp Leu Leu Asp Ile 
                725                 730                 735     


Ala Ser Lys Ala Glu Pro Ser Asn Asp Ala Pro Asn Leu Pro Asp Pro 
            740                 745                 750         


Val Asp Thr Gly Lys Asp Thr Val Phe Glu Asp Trp Gln Ala Leu Leu 
        755                 760                 765             


Tyr Leu Phe Leu His Phe Val Pro Ala Asp Asp Val Ser Gln Leu Leu 
    770                 775                 780                 


His Gln Leu Arg Lys Trp Asp Ala Leu Gln Asp Lys Tyr Glu Leu Ala 
785                 790                 795                 800 


Glu Pro Gly Glu Thr Leu Gly Gln Thr Lys Ala Asp Thr Arg Lys Ile 
                805                 810                 815     


Val Gly Gln Phe Arg Asp Cys Leu Thr Leu Phe Leu Lys Thr Gly Asp 
            820                 825                 830         


Ala Arg Phe Asp Gly Glu Gly Val Glu Leu Pro Leu Ser Asp Phe Gln 
        835                 840                 845             


Glu Leu Phe Glu Ser Pro Ala Thr Phe Lys Glu Leu Phe Leu Ala Glu 
    850                 855                 860                 


Pro Ala Glu Asn Asp Ala Ser Glu Thr Asp Asp Gln Asp Ala Pro Gly 
865                 870                 875                 880 


Glu Lys His Arg Val Thr Arg Thr Arg Arg Gly Leu Arg Gln Ile Leu 
                885                 890                 895     


Arg Tyr Asn His Met Pro Val Leu Arg Asp Leu Phe Leu Ala His Lys 
            900                 905                 910         


Val Thr Asp Ala Glu Val Asp Gly Leu Gln Ala Leu Glu Val Asp Asp 
        915                 920                 925             


Pro Gln Thr Gly Glu Ser Gln Ile Gly Ala Ala Gln Arg Ile Arg Thr 
    930                 935                 940                 


Glu Ile His His His Thr Ser Asn Asp Lys Gln Ile Ser Glu Ala Lys 
945                 950                 955                 960 


Val Glu Glu Tyr Arg Arg Ala Leu Ser Thr Ile Glu Arg His Arg Phe 
                965                 970                 975     


Leu Val Gly Arg Val Tyr Leu Gly Asp His Ile Arg Val His Lys Leu 
            980                 985                 990         


Met Met Asp Val Met Gly Arg Leu  Val Asp Phe Ala Gly  Ala Trp Glu 
        995                 1000                 1005             


Arg Glu  Ala Ala Asp Gly Asp  Arg Lys Gly Phe Ile  Ser Arg Ala 
    1010                 1015                 1020             


Ile Ala  Leu Pro Glu Val Ala  Glu Gly Tyr Ala Ala  Asp Arg Leu 
    1025                 1030                 1035             


Lys Thr  Val Ala Arg Arg Val  Leu Asp Asp Gly Glu  Ala Arg Arg 
    1040                 1045                 1050             


Ile Arg  Asn Asp Leu Gly His  Phe Asn Asp Leu Ala  Pro Thr Ser 
    1055                 1060                 1065             


Gly Pro  Ala Asn Leu Thr Phe  Val Val Asn Arg Ala  Arg Arg Met 
    1070                 1075                 1080             


Met Arg  His Asp Arg Lys Arg  Lys Asn Ala Val Thr  Lys Ser Val 
    1085                 1090                 1095             


Ile Glu  Ile Leu Asn Arg Gln  Gly Leu Gly Ile Glu  Trp Thr Met 
    1100                 1105                 1110             


Arg Asn  His Glu Leu Cys Glu  Ala Lys Leu Trp Gln  Asn Pro Val 
    1115                 1120                 1125             


Lys His  Leu Gly Phe Ala Thr  Leu Glu Gly Arg Gly  Lys Lys Trp 
    1130                 1135                 1140             


Arg Arg  Pro Phe Glu Ala Arg  Tyr Gly Asp Ala Tyr  Met Ala Met 
    1145                 1150                 1155             


Val Ala  Gln Leu Phe Asp Gly  Thr Val Thr Ser Pro  Pro Ala Lys 
    1160                 1165                 1170             


Gly Pro  Pro Gln Ser Gly Lys  Ser Gly Gly Lys Pro  Gly Lys Gly 
    1175                 1180                 1185             


Ala Glu  Gly Gly Ala Lys Glu  Lys Ser Arg Ser Pro  Thr Arg Met 
    1190                 1195                 1200             


Glu Glu  Gly Gly Val Tyr Glu  Gly Arg Val Ala Lys  Ala Lys Ser 
    1205                 1210                 1215             


Asp Lys  Gly Phe Gly Phe Leu  Leu Val Glu Gly Ala  Gln Glu Glu 
    1220                 1225                 1230             


Ile Phe  Leu His Ile Tyr Gly  Ile Ser Gly Asn Arg  Pro Ala Arg 
    1235                 1240                 1245             


Ile Glu  Asn Gly Gln Arg Tyr  Arg Phe Thr Leu Gly  Ile Asp Arg 
    1250                 1255                 1260             


Asp Arg  Glu Arg Arg Lys Glu  Arg Ala Trp Val Ala  Arg Glu Ala 
    1265                 1270                 1275             


Val Arg  Ile Asp Glu Asn Arg  Ser Lys 
    1280                 1285         


<210>  106
<211>  1101
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  106

Met Arg Ile Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Ile Tyr Ser Glu 
            20                  25                  30          


Gln Ala Val Ser Asn Glu Thr Asn Asn Ile Leu Pro Val Lys Lys Met 
        35                  40                  45              


Asp Ser Phe Asn Leu Ser Ile Leu Asn Lys Thr Ile Ile Lys Phe Glu 
    50                  55                  60                  


Thr Val Lys Lys Gln Lys Leu Asn Leu Asp Gln Tyr Lys Ile Val Glu 
65                  70                  75                  80  


Lys Ile Phe Lys Tyr Pro Lys Gln Glu Leu Pro Lys Gln Ile Asn Ala 
                85                  90                  95      


Glu Glu Ile Leu Gln Phe Leu Asn His Lys Phe Gln Glu Pro Val Lys 
            100                 105                 110         


Tyr Trp Lys Asn Gly Lys Glu Glu Ser Phe Asn Leu Thr Leu Leu Ile 
        115                 120                 125             


Val Glu Ala Val Lys Thr Gln Glu Lys Arg Lys Leu Gln Pro Tyr Tyr 
    130                 135                 140                 


Asp Trp Lys Thr Trp Tyr Ile Gln Thr Lys Ser Asp Leu Leu Lys Lys 
145                 150                 155                 160 


Ser Ile Glu Asn Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg 
                165                 170                 175     


Lys Lys Ala Leu Leu Ala Trp Glu Thr Glu Phe Thr Thr Ser Gly Ser 
            180                 185                 190         


Ile Asp Leu Thr His Phe His Lys Val Tyr Met Thr Asp Val Leu Cys 
        195                 200                 205             


Thr Ala Leu Gln Lys Val Glu Pro Ser Ala Asp Glu Arg Gly Lys Met 
    210                 215                 220                 


Asn Ser Asn Ala Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Asn His 
225                 230                 235                 240 


Gln Pro Ala Ile Phe Gly Thr Arg Glu Ala Pro Asn Glu Val Asn Arg 
                245                 250                 255     


Ala Asp Asn Gln Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu 
            260                 265                 270         


Glu His Tyr Phe Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Ala Asp 
        275                 280                 285             


Asp Ile Ser His Tyr Leu Lys Ala Gln Thr Leu Lys Thr Thr Ile Glu 
    290                 295                 300                 


Lys Gln Leu Val Asn Ala Ile Arg Ala Asn Ile Ile Gln Gln Gly Lys 
305                 310                 315                 320 


Thr Asn His His Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile 
                325                 330                 335     


Arg Ile Lys Thr Asn Glu Ala Phe Val Leu Asn Leu Ile Gly Thr Cys 
            340                 345                 350         


Ala Phe Ala Ala Asn Asn Ile Arg Asn Met Val Asp Lys Glu Gln Ile 
        355                 360                 365             


Ser Asp Ile Leu Gly Lys Arg Glu Phe Ile Asp Ser Leu Thr Lys Ser 
    370                 375                 380                 


Arg Ile Ser Ser Gln Leu Tyr Ser Phe Phe Phe Gly Glu Asn Leu Ser 
385                 390                 395                 400 


Thr Asn Lys Ala Glu Lys Glu Thr Gln Leu Trp Gly Ile Arg Gly Ala 
                405                 410                 415     


Val Gln Gln Ile Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu 
            420                 425                 430         


Thr Thr Ile Phe Asn Ile Cys Lys Phe Glu Asn Pro Thr Asp Ala Asp 
        435                 440                 445             


Pro Lys Gln Gln Thr Asn Tyr Val Asp Ser Ile Tyr Lys Thr Leu Phe 
    450                 455                 460                 


Ile Lys Glu Leu Glu Lys Ile Pro Glu Ala Phe Ala Gln Gln Leu Lys 
465                 470                 475                 480 


Thr Gly Gly Ala Leu Ser Tyr Tyr Thr Val Glu Asn Leu Lys Thr Leu 
                485                 490                 495     


Leu Thr Thr Phe Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala 
            500                 505                 510         


Pro Gly Phe Lys Lys Val Leu Asn Gly Gly Ile Asn Tyr Gln Asn Ala 
        515                 520                 525             


Lys Gln Asp Glu Ser Phe Tyr Glu Leu Met Leu Glu Arg Tyr Leu Arg 
    530                 535                 540                 


Lys Glu Asn Phe Ala Glu Glu Ala Tyr Asn Ala Arg Tyr Phe Leu Leu 
545                 550                 555                 560 


Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Lys Phe Thr Ala Asp Arg 
                565                 570                 575     


Lys Ala Phe Ala Asp Ser Val Gly Phe Val Gln Leu Gln Asn Arg Lys 
            580                 585                 590         


Gln Ala Glu Asn Ser Lys Arg Pro Lys Ala Phe Ala Phe Glu Ala Val 
        595                 600                 605             


Arg Pro Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala Tyr Val 
    610                 615                 620                 


Gln Ser Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys Ala Thr 
625                 630                 635                 640 


Asp Glu Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val Phe Ile 
                645                 650                 655     


Lys Gly Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe Val Gln 
            660                 665                 670         


Val Pro Gln Pro Gln Leu Thr Thr Thr Asp Ser Asn Gln Gln Lys Ala 
        675                 680                 685             


Asp Lys Leu Asn Gln Leu Glu Ala Ser Ile Thr Ala Asp Cys Lys Leu 
    690                 695                 700                 


Thr Ala Gln Tyr Ala Lys Thr Asp Asp Ala Thr His Ile Ala Phe Tyr 
705                 710                 715                 720 


Val Phe Cys Lys Leu Leu Asp Ala Gly His Leu Ser Asn Leu Arg Asn 
                725                 730                 735     


Glu Leu Ile Lys Phe Arg Gly Ser Val Lys Asp Phe Asp Phe His His 
            740                 745                 750         


Leu Leu Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val Val Pro 
        755                 760                 765             


Thr Asp Tyr Arg Asp Leu Tyr Ser Ser Gly Ala Asp Cys Leu Ala Arg 
    770                 775                 780                 


Leu Arg Pro Phe Ile Glu Gln Gly Ala Asp Ile Lys Asn Trp Ser Asp 
785                 790                 795                 800 


Leu Tyr Val Gln Thr Asp Lys Gln Thr Pro Val Ile His Ala Gly Ile 
                805                 810                 815     


Glu Leu Ser Val Lys Tyr Gly Thr Thr Ala Leu Leu Glu Gln Leu Ile 
            820                 825                 830         


Thr Cys Asn Pro Lys Phe Arg Val Met Glu Asp Asn Phe Thr Lys Trp 
        835                 840                 845             


Ser Ala Gln Lys Lys Glu Ile Glu Glu Lys Val Asn Lys His Thr Asn 
    850                 855                 860                 


Leu His Gln Gln Trp Val Glu Ala Lys Glu Lys Asp Asp Arg Glu Arg 
865                 870                 875                 880 


Val Lys Ser Lys Lys Asn Phe Val Arg Glu Tyr Val Lys Lys Asn Tyr 
                885                 890                 895     


Val Asp Tyr Ile Asn Asn Cys Ile Glu Ile Asn Asn Tyr Asn Trp Leu 
            900                 905                 910         


Asp Asn Lys Leu His Phe Val His Leu Asn His Leu His His Leu Thr 
        915                 920                 925             


Ile Asp Ile Leu Gly Arg Met Ala Gly Phe Val Ala Leu Trp Glu Arg 
    930                 935                 940                 


Asp Phe Gln Tyr Ile Thr Lys Tyr Thr Ala Ala Lys Glu Gly Thr Asp 
945                 950                 955                 960 


Ala Leu Ser Phe Asp Gly Gly Leu Pro Arg Leu Lys Asp Lys Gln Glu 
                965                 970                 975     


Tyr Tyr Asn Lys Leu Phe Leu Ser Asp Lys Tyr Thr Lys Val Arg Asn 
            980                 985                 990         


His Ile Ala His Phe Asn Tyr Leu  Thr Lys Asp Ala Ala  Asp Phe Ala 
        995                 1000                 1005             


Leu Leu  Asp Leu Ile Asn Glu  Leu Arg Glu Leu Leu  His Tyr Gly 
    1010                 1015                 1020             


Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ala Phe Ile  Asp Leu Phe 
    1025                 1030                 1035             


Glu Lys  His Gly Met Ile Leu  Lys Leu Lys Leu Asn  Thr Asp His 
    1040                 1045                 1050             


Gln Leu  Val Val Glu Ser Ile  Glu Pro Lys Lys Ile  Tyr His Leu 
    1055                 1060                 1065             


Gly Ser  Thr Ala Lys Asp Lys  Pro Glu Tyr Gln Tyr  Thr Thr Asn 
    1070                 1075                 1080             


Gln Val  Met Thr Val Tyr Cys  Asn Met Cys Arg Ser  Leu Leu Glu 
    1085                 1090                 1095             


Met Lys  Lys 
    1100     


<210>  107
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  107

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Pro Gly Thr Asp Thr 
            20                  25                  30          


Ile Asp Leu Lys Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Lys Val Phe Asn Gln Ile Gln Val Gly Asn Lys Pro Lys Lys 
    50                  55                  60                  


Trp Lys Lys Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Glu Tyr Val Glu Ser Ser Gln Arg Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Asp Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Glu Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Gly Leu Phe Val Asn Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Ile Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Ser Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Tyr Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Lys Asp Arg Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Lys Glu Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Gln Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Phe 
            660                 665                 670         


Ile Arg Lys Asn Phe Pro Glu Asp Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Lys Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Tyr 
                805                 810                 815     


Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Thr 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Trp Ser Leu 
        915                 920                 925             


Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Asp Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Asp Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asn  Ser Glu Lys Lys Glu  Ala Tyr Gln Lys Ile  Glu Val Asn 
    1100                 1105                 1110             


Gly Asp  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Val  Tyr Ala Pro Asp Glu  Lys Gly Asp 
    1130                 1135                 1140             


Ile Leu  Lys Glu Gln Cys Thr  Lys Gly Gly Ala Gly  Gly Lys Ile 
    1145                 1150                 1155             


Ser Ala  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Lys Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Lys Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Lys Gln 
    1250                 1255                 1260             


Thr Thr  Ser Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Ser Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Lys  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Val Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Gly Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Pro Asn 
    1370                 1375                 1380         


<210>  108
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  108

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Asp Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn Tyr Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Gly Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Gly Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Lys Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  109
<211>  918
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  109

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Ile Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Asp Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr 
        915             


<210>  110
<211>  1369
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  110

Met Lys Ile Ser Lys Glu Gly His Lys Arg Thr Ala Val Ala Val Met 
1               5                   10                  15      


Glu Asn Arg Ala Gly Gly Val Val Tyr Lys Val Pro Gly Gly Ser Gly 
            20                  25                  30          


Ile Asp Leu Thr Gly Tyr Leu Thr Glu Arg Ser Glu Asn Thr Lys Ile 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Ala Gly Thr Ala Pro Ser Glu 
    50                  55                  60                  


Tyr Glu Trp Lys Asp Tyr Leu Ser Glu Thr Glu Asn Lys Lys Arg Glu 
65                  70                  75                  80  


Ala Gln Lys Thr Val Gln Lys Ala Asn Tyr Glu Leu Arg Arg Ala Cys 
                85                  90                  95      


Glu Asn Tyr Ala Lys Lys Ala Asn Phe Thr Val Arg Lys Ile Ile Phe 
            100                 105                 110         


Ser Glu Lys Pro Lys Arg Met Leu Ser Asp Asn Gln Ile Ile Ser Asn 
        115                 120                 125             


Met Gln Asn Gln Arg Leu Pro Gln Phe Lys Gly Lys Ile Glu Asp Phe 
    130                 135                 140                 


Val Leu Ile Thr Leu Arg Lys Ser Leu Val Val Ser Thr Tyr Asn Lys 
145                 150                 155                 160 


Glu Ile Phe Asp Ser Arg Lys Ala Ala Thr Val Phe Leu Lys Asn Ile 
                165                 170                 175     


Gly Lys Glu Asn Ile Ser Val Asp Asp Glu Arg Gln Ile Lys Gln Leu 
            180                 185                 190         


Leu Ala Leu Ile Arg Glu Asp Tyr Asn Lys Trp Asn Pro Asp Glu Asn 
        195                 200                 205             


Ser Ser Asp Lys Lys Glu Ser Ser Gly Thr Met Ile Ile Arg Ser Ile 
    210                 215                 220                 


Glu His Gln Asp Met Val Ile Gln Pro Glu Glu Asn Lys Leu Ser Leu 
225                 230                 235                 240 


Ser Lys Ile Ser Asn Val Gly Lys Lys Thr Lys Thr Lys Gln Ile Glu 
                245                 250                 255     


Lys Ala Gly Leu Asp Ala Phe Leu Thr Glu Tyr Ala Gln Ile Asp Glu 
            260                 265                 270         


Ser Gly Arg Met Glu Cys Leu Lys Lys Leu Arg Arg Leu Leu Asp Thr 
        275                 280                 285             


Tyr Phe Ala Ala Pro Ser Ser Tyr Val Lys Gly Thr Glu Val Ser Leu 
    290                 295                 300                 


Pro Glu Asn Ile Asn Phe Ser Ser Glu Leu Asn Val Trp Glu Arg His 
305                 310                 315                 320 


Glu Thr Ala Lys Lys Val Asn Ile Tyr Phe Val Glu Ile Pro Glu Val 
                325                 330                 335     


Leu Leu Lys Ala Glu Gln Asn Asn Asn Ile Ile Asn Lys Val Glu Lys 
            340                 345                 350         


Glu His Ser Leu Glu Gln Leu Arg Thr Asp Ile Arg Arg Arg Asn Ile 
        355                 360                 365             


Ala Cys Tyr His Phe Ala Asn Ala Leu Ala Ala Asp Glu Arg Tyr His 
    370                 375                 380                 


Arg Phe Phe Leu Glu Asn Met Ala Met Asn Gln Tyr Trp Ile His His 
385                 390                 395                 400 


Met Glu Asn Ala Val Glu Arg Ile Leu Lys Lys Cys Asn Val Gly Thr 
                405                 410                 415     


Leu Phe Lys Leu Lys Ile Gly Tyr Leu Ser Glu Lys Val Trp Lys Asp 
            420                 425                 430         


Ile Leu Asn Leu Leu Ser Ile Lys Tyr Ile Ala Leu Gly Lys Ala Val 
        435                 440                 445             


Tyr His Phe Ala Leu Asp Asp Ile Trp Asn Asp Ser Tyr Asp Lys Lys 
    450                 455                 460                 


Pro Gly Lys Ile Asn Asp Phe Ala Ile Lys Gly Ile Ser Ser Phe Asp 
465                 470                 475                 480 


Tyr Glu Met Val Lys Ala Gln Glu Asp Leu Gln Arg Glu Met Ala Val 
                485                 490                 495     


Asp Val Ala Phe Ser Thr Asn Asn Leu Ala Arg Ala Thr Cys Gln Met 
            500                 505                 510         


Glu Asn Leu Ser Asp Arg Glu Ser Asp Phe Leu Leu Trp Asp Asp Lys 
        515                 520                 525             


Thr Ile Ala Arg His Val Lys Tyr Thr Glu Lys Gly Glu Ile Leu Ser 
    530                 535                 540                 


Ala Ile Leu Gln Phe Phe Gly Gly Arg Ser Ser Trp Asp Glu Ser Leu 
545                 550                 555                 560 


Phe Glu Asn Ala Tyr Ser Asp Ser Asn Tyr Glu Leu Gln Phe Leu Asn 
                565                 570                 575     


Asp Leu Arg Arg Ala Ile Tyr Ala Val Arg Asn Glu Thr Phe His Phe 
            580                 585                 590         


Lys Thr Ala Ala Ile Asp Glu Gly Ser Trp Asn Thr Arg Leu Phe Gly 
        595                 600                 605             


Asn Leu Phe Glu Lys Glu Ala Gly Ile Cys Leu Asp Val Glu Lys Asn 
    610                 615                 620                 


Lys Phe Tyr Ser Asn Asn Leu Ala Leu Phe Tyr Thr Gln Lys Asp Leu 
625                 630                 635                 640 


Asn Val Ile Leu Asp Lys Leu Tyr Gly Lys Glu Cys Ser Arg Ala Ala 
                645                 650                 655     


Gln Ile Leu Ser Tyr Asn Thr Ile Leu Pro Arg Lys Ser Phe Pro Asp 
            660                 665                 670         


Phe Leu Lys Gln Leu Leu Lys Leu Gln Glu Pro Val Tyr Asp Leu Thr 
        675                 680                 685             


Ile Gln Asp Gln Trp Tyr Ser Ala Cys Tyr Tyr Leu Phe Lys Glu Val 
    690                 695                 700                 


Tyr Tyr Asn Ala Phe Leu Gln Asp Ser Ser Ala Lys Ala Leu Phe Glu 
705                 710                 715                 720 


Asp Ala Val Lys Ala Leu Lys Gly Thr Asp Ile Lys Gln Glu Arg Ala 
                725                 730                 735     


Ile Glu Asn Phe Thr Lys Arg Tyr Trp Glu Ile Ser Lys Asn Ala Ser 
            740                 745                 750         


Leu Ala Glu Ile Cys Gln Ser Phe Met Thr Glu Tyr Asn Gln Gln Asn 
        755                 760                 765             


Asn Lys Glu Arg Lys Val Gln Ser Ala Asn Asp Ser Met Phe Asn Glu 
    770                 775                 780                 


Pro Ile Tyr Gln His Tyr Lys Met Leu Leu Lys Glu Ala Leu Lys Met 
785                 790                 795                 800 


Ala Phe Ala Ser Tyr Ile Lys Asn Ser Lys Glu Leu Glu Phe Val Tyr 
                805                 810                 815     


Asn Pro Thr Lys Glu Leu Phe Lys Val Ser Gln Asp Ser Phe Leu Pro 
            820                 825                 830         


Asn Trp Asn Ser Arg Lys Tyr Asp Ala Leu Ile Ser Glu Val Lys Asn 
        835                 840                 845             


Ser Pro Asp Leu Gln Lys Trp Tyr Ile Val Gly Lys Phe Met Asn Ala 
    850                 855                 860                 


Arg Thr Leu Asn Leu Leu Ile Gly Ser Met Arg Ser Tyr Leu Gln Tyr 
865                 870                 875                 880 


Val Ser Asp Ile Gln Lys Arg Ala Asp Gly Leu Gly Glu Tyr Gln Leu 
                885                 890                 895     


His Leu Phe Ala Gly Asn Val Glu Gln Val Lys Lys Trp Ile Gln Ile 
            900                 905                 910         


Leu Glu Val Cys Leu Leu Leu Ser Val Arg Ile Ser Asp Lys Phe Thr 
        915                 920                 925             


Asp Tyr Phe Lys Asp Lys Glu Ala Tyr Ala Ser Tyr Leu Lys Gly Tyr 
    930                 935                 940                 


Val Asp Phe Glu Asp Ser Ala Met Pro Leu Asp Tyr Ser Ala Leu Leu 
945                 950                 955                 960 


Ala Phe Gly Asn Glu Gly Lys Ile Asp Leu Tyr Val Asp Ala Ser Asn 
                965                 970                 975     


Pro Lys Val Asn Arg Asn Ile Ile Gln Ala Lys Leu Tyr Ala Pro Asp 
            980                 985                 990         


Met Val Leu Lys Lys Val Val Lys  Lys Ile Ser Gln Asn  Glu Cys Arg 
        995                 1000                 1005             


Glu Phe  Asn Glu Lys Lys Glu  Gln Ile Leu Gln Thr  Lys Asn Lys 
    1010                 1015                 1020             


Gly Asp  Thr Val Ser Trp Glu  Glu Gln Gln Gln Ile  Leu Glu Tyr 
    1025                 1030                 1035             


Gln Arg  Leu Lys Asn Arg Val  Glu Leu Arg Asp Leu  Ser Asp Tyr 
    1040                 1045                 1050             


Gly Glu  Leu Ile Asn Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser 
    1055                 1060                 1065             


Tyr Leu  Arg Glu Arg Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His 
    1070                 1075                 1080             


Tyr Arg  Cys Leu Met Asn Glu  Ser Lys Lys Pro Asp  Ala Tyr Lys 
    1085                 1090                 1095             


Thr Ile  Cys Thr Asp Thr Val  Phe Ile Glu Asn Ala  Val Leu Tyr 
    1100                 1105                 1110             


Gln Ile  Ile Ala Met Tyr Ile  Asn Gly Phe Pro Val  Tyr Val Pro 
    1115                 1120                 1125             


Glu Lys  Gly Lys Leu Lys Ala  Arg Cys Lys Thr Gly  Ser Ala Gly 
    1130                 1135                 1140             


Leu Lys  Ile Gly Ala Phe Cys  Gln Trp Ala Ser Thr  Val Glu Lys 
    1145                 1150                 1155             


Lys Lys  Tyr Glu Leu Tyr Asn  Ala Gly Leu Glu Leu  Phe Glu Val 
    1160                 1165                 1170             


Val Gly  Glu His Asp Asn Ile  Val Glu Leu Arg Asn  Lys Ile Asp 
    1175                 1180                 1185             


His Phe  Lys Tyr Tyr Gln Gly  Asn Asp Ser Ile Leu  Ser Leu Tyr 
    1190                 1195                 1200             


Gly Glu  Ile Phe Asp Arg Phe  Phe Thr Tyr Asp Met  Lys Tyr Arg 
    1205                 1210                 1215             


Lys Asn  Val Leu Asn His Leu  Gln Asn Ile Leu Leu  Arg His Asn 
    1220                 1225                 1230             


Val Val  Ile Lys Pro Ile Ile  Ser Lys Asp Gln Lys  Lys Val Gly 
    1235                 1240                 1245             


Lys Gly  Glu Thr Lys Asp Arg  Ala Ala Phe Leu Leu  Glu Glu Ile 
    1250                 1255                 1260             


Asn Ser  Asp Arg Phe Thr Tyr  Lys Val Lys Glu Gly  Glu Arg Lys 
    1265                 1270                 1275             


Ile Asp  Ala Lys Asn Arg Leu  Tyr Leu Glu Thr Val  Arg Asp Ile 
    1280                 1285                 1290             


Leu Tyr  Phe Pro Asn Arg Ala  Val Asn Asp Lys Gly  Gly Asp Ile 
    1295                 1300                 1305             


Ile Val  Arg Ser Gln Lys Ala  Gln Asp Leu Asn Glu  Lys Lys Ala 
    1310                 1315                 1320             


Asp Arg  Asp Lys Asn Tyr Asp  Asn Ser Lys Asn Gly  Lys Arg Gly 
    1325                 1330                 1335             


Lys Gly  Ser Asn Asn Gln Gly  Lys Lys Glu Lys Asn  Lys Glu Ser 
    1340                 1345                 1350             


Tyr Ser  Asn His Ile Thr Trp  Asn Pro Phe Val Gly  Ile Lys Leu 
    1355                 1360                 1365             


Glu 
    


<210>  111
<211>  1217
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  111

Met Arg Ile Thr Lys Val Lys Val Glu Ala Gly Glu Asn Gly Asn Pro 
1               5                   10                  15      


Gly Ser Asp Lys Gly Lys Met Val Phe Leu Gln Arg Glu Val Lys Lys 
            20                  25                  30          


Gly Ser Leu Val Leu Glu Gly Phe Ser Ser Gly Ala Ser Glu Ile Glu 
        35                  40                  45              


Gly Asp His Leu Ser Asp Arg Thr Thr Asp Ile Ile Gln Gln Tyr Lys 
    50                  55                  60                  


Asn Arg Ser Phe Gly Leu Ser Leu Leu Lys Gln Thr Val Ile Ser Lys 
65                  70                  75                  80  


Asp Lys Leu Gln Lys Val His Cys Glu Lys Cys Lys Gly Lys Lys Pro 
                85                  90                  95      


Cys Glu Ala Cys Lys Lys Lys Tyr Glu His Lys Lys Val Ile Cys Ser 
            100                 105                 110         


Thr Leu Glu Arg Ile Phe Lys Pro Val Ile Glu Asp Val Ile Tyr Gly 
        115                 120                 125             


Lys Arg Ile Asp Tyr Asp Tyr Glu Asn Ile Lys Phe Ser Ser Gln Leu 
    130                 135                 140                 


Ser Leu Cys Lys Glu Glu Leu Ser Asn Phe Leu Cys His Lys Phe Arg 
145                 150                 155                 160 


Asp Thr Leu Arg Tyr Asn Asp Val Leu Lys Val Arg Arg Glu Val Asn 
                165                 170                 175     


Leu Ile Asp Cys Leu Gly Lys Phe Ile Asp Ser Lys Gly Arg Met Glu 
            180                 185                 190         


Ser Leu Arg Ala Tyr Cys Asp Trp Ala Glu Ala Tyr Ile Val Arg Lys 
        195                 200                 205             


Lys Ala Met Leu Glu Lys Ser Val Gln Asn Asn Arg Ile Val Phe Asp 
    210                 215                 220                 


Tyr Ser Glu Thr Glu Thr Thr Gly Leu Ser Lys Arg Lys Gln Ala Leu 
225                 230                 235                 240 


Leu Lys Trp Gly Lys Asp Tyr Glu Asp Lys Ser Arg Ser Asn Gln Gly 
                245                 250                 255     


Ala Ile Ser Pro Ile Asp Ala Ala Ser Ser Val His Tyr Asn Ile Asn 
            260                 265                 270         


Leu Asp Asp Phe His Arg Ala Phe Lys Ile Asp Asp Leu Cys Asn Ala 
        275                 280                 285             


Phe Ala Leu Thr Leu Glu Lys Gln Leu Ala Leu Leu Lys Glu Gln Glu 
    290                 295                 300                 


Glu Gln Lys His Lys Gln Pro Asn Leu Gln Asn Thr Tyr Ser Ala His 
305                 310                 315                 320 


Asn Gln Pro Thr Glu Thr Lys Thr Lys Leu Val Leu Thr Ser Ser Val 
                325                 330                 335     


Cys Ala Leu Leu Lys Lys Thr Leu Gln Glu His Gln Ala Thr Trp Val 
            340                 345                 350         


Phe Gly Arg Gln Ala Asp Leu Glu Lys Glu Asn Val Asp Pro Ala Arg 
        355                 360                 365             


Asp Ala Phe Ile Lys His Arg Asn Asp Cys Gln Leu Tyr Ala Tyr Asn 
    370                 375                 380                 


Leu Glu Val Val Lys Tyr Leu Glu His Tyr Phe Pro Ile Lys Arg Lys 
385                 390                 395                 400 


Lys Pro Leu Pro Asp Glu Glu Ser Ala Arg Tyr Tyr Leu Asn Pro Glu 
                405                 410                 415     


Thr Ile Lys Lys Arg Ile Gln Phe Gln Leu Glu Asn Ala Val Arg Met 
            420                 425                 430         


Gln Leu Leu Gln Gln Gly Lys Leu Lys His His Glu Leu Asp Glu Arg 
        435                 440                 445             


Val Asn Ser Glu Thr Leu Ser Ser Ile Lys Arg Asp Asp Phe Phe Val 
    450                 455                 460                 


Leu Asn Leu Val Glu Ala Cys Ala Phe Ala Ala Ser Asn Ile Arg Asn 
465                 470                 475                 480 


Ile Ile Asp His Glu Gln Lys Lys Asp Ile Leu Gly Lys Val Asp Phe 
                485                 490                 495     


Lys Asn Ser Leu Ala Ser Ala Arg Phe Asp Gly Glu Leu Cys Lys Tyr 
            500                 505                 510         


Phe Tyr Glu Thr Asn Leu Lys Thr Asp Cys Gln Ala Leu Trp Ala Met 
        515                 520                 525             


Arg Gly Ala Val Gln Gln Ile Arg Asn Gly Ile Val His Tyr His Lys 
    530                 535                 540                 


Gly Leu Ile Glu Ser Val Phe Lys Leu Asp Thr Phe Glu Tyr Glu Asn 
545                 550                 555                 560 


Ala Val Asp Ser Glu Lys Gln Tyr Thr His Thr Val Phe Lys Glu Leu 
                565                 570                 575     


Leu Gln Lys Ser Leu Ala Lys Leu Asp Gly Tyr Ile Val Glu Gln Phe 
            580                 585                 590         


Arg Ser Asn Asp Val Leu Ser Tyr Tyr Glu Ala Ser Asp Leu Asn Lys 
        595                 600                 605             


Leu Phe Gly Glu Gln Ser Leu Ser Leu His Arg His Ser Ile Pro Phe 
    610                 615                 620                 


Ala Pro Gly Phe Lys Asn Ile Tyr Asp Ser Gly Ala Lys Leu Gln Gln 
625                 630                 635                 640 


Gly Ser Thr Gly Met Arg Leu Asn His Phe Leu Leu Ala Glu Asn Asn 
                645                 650                 655     


Glu Ala Ser Leu Thr Arg Glu Gly Lys Glu Leu Ser Phe Ser Arg Lys 
            660                 665                 670         


Leu Ser Pro Ala Ala Thr Lys Leu Ser Pro Ala Tyr Pro Ala Phe Arg 
        675                 680                 685             


Phe Leu Leu Lys Leu Ile Tyr Asn His Leu Phe Leu Asn Phe Phe Leu 
    690                 695                 700                 


Asn Ser Glu Asp Asn Ala Ser Phe Arg Asn Ala Val Ala Phe Val Leu 
705                 710                 715                 720 


Lys Asn Asn Arg Glu Glu Ala Met Gln Ala Leu Arg Glu Ser Ala Lys 
                725                 730                 735     


Lys His Pro Gly Ser Arg Ser Ser Lys Pro Leu Leu Pro Gln Lys Tyr 
            740                 745                 750         


Ala Phe Arg Glu Ile Arg Gly Val Gln Asn Gly Glu Asp Ile Ala Ser 
        755                 760                 765             


Tyr Met Ser Tyr Leu His Ser Phe Ser Val Gln Glu Gln Glu Arg Lys 
    770                 775                 780                 


Gly Asp Gly Asn Glu Asn Gly Glu Thr Val Arg Arg Asn Thr Glu Lys 
785                 790                 795                 800 


Phe Leu Lys Gln Val Phe Val Lys Gly Phe Asp Thr Tyr Leu Ser Arg 
                805                 810                 815     


Leu Pro Leu His Phe Leu Tyr Thr Pro Asn Ile Glu Lys Val Gln Glu 
            820                 825                 830         


Asp Lys Asp His Tyr Val Asp Leu Asp Ile Lys Val Lys His Gln Ile 
        835                 840                 845             


Asp Cys Thr Lys Gly Ala His Ile Ser Phe Phe Ala Phe Cys Lys Leu 
    850                 855                 860                 


Leu Asp Gly Asn His Leu Ser Asp Leu Arg Asn Glu Leu Leu Lys Tyr 
865                 870                 875                 880 


Ser Ala Thr Ser Lys Ala Met Gly Ser Ser Val Glu Tyr Asn Phe Ala 
                885                 890                 895     


Phe Asp Val Ile Glu Leu Cys Leu Leu Asp Asn Asp Lys Arg Met Glu 
            900                 905                 910         


Phe Asp Lys Glu Gly Gln Val Val Asn Ser Asp Thr Lys Ser Lys Leu 
        915                 920                 925             


Cys Lys Gly Thr Tyr Lys Lys Leu Leu Ala Pro Phe Val Lys Gly Asp 
    930                 935                 940                 


Glu Lys Thr Asn Arg Ile Trp Met Ala Phe Tyr Phe Gln Ser Asp Lys 
945                 950                 955                 960 


Glu Thr Pro Val Asp Tyr Gly Ser Leu Ala Leu Ile Arg Lys Phe Gly 
                965                 970                 975     


Thr Gln Lys Leu Leu Glu Ala Leu Ile Thr Asp Glu Tyr Lys Val Thr 
            980                 985                 990         


Glu Gln Asp Tyr Asp Glu Trp Val  Ala Leu Lys Arg Asp  Ile Asp Lys 
        995                 1000                 1005             


Lys Val  Gln Glu Arg Glu Gln  Leu His Ala Glu Trp  Val Glu Ala 
    1010                 1015                 1020             


Gly Gly  Lys Phe Val Ser Glu  Ser Asn Thr Asp Val  Tyr Phe Lys 
    1025                 1030                 1035             


Leu Cys  Lys Asp Ile Glu Arg  Tyr Asn Trp Leu Asp  Asn Lys Leu 
    1040                 1045                 1050             


His Leu  Val His Leu Lys Gln  Leu His Asn Phe Ile  Ile Gln Ile 
    1055                 1060                 1065             


Leu Ser  Arg Met Ala Arg Phe  Val Ala Met Arg Asp  Arg Asp Leu 
    1070                 1075                 1080             


Ala Phe  Val Lys Glu Leu Arg  Phe Pro Ala Tyr His  Lys Ser Phe 
    1085                 1090                 1095             


Phe Met  Gln Asp Asp Thr Leu  Lys Glu Cys Arg Asn  Tyr Ile Ala 
    1100                 1105                 1110             


His Phe  Asn Tyr Val Thr Thr  Thr Ala Ser Ser Ser  Leu Ile Asp 
    1115                 1120                 1125             


Ile Leu  Asn Ser Leu Arg Glu  Leu Met Ala Tyr Asp  Arg Lys Leu 
    1130                 1135                 1140             


Arg Asn  Ala Val Thr Lys Ser  Ile Ile His Val Phe  Lys Gln Asn 
    1145                 1150                 1155             


Gly Met  Asn Leu Gln Leu Gly  Trp Val Asp Asn Gly  Arg Lys Ser 
    1160                 1165                 1170             


Asp Ser  Ile His Arg Leu Met  Val Lys Ser Val Lys  Ser Glu Pro 
    1175                 1180                 1185             


Ile Lys  Leu Leu Lys Ala Glu  Leu Thr Ile Asp Gln  Val Pro Glu 
    1190                 1195                 1200             


Glu Tyr  Cys Arg Leu Cys Lys  Trp Leu Leu Glu Met  Lys Lys 
    1205                 1210                 1215         


<210>  112
<211>  1217
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  112

Met Arg Ile Thr Lys Val Lys Val Glu Ala Gly Glu Asn Gly Asn Pro 
1               5                   10                  15      


Gly Ser Asp Lys Gly Lys Met Val Phe Leu Gln Arg Glu Val Lys Lys 
            20                  25                  30          


Gly Ser Leu Val Leu Glu Gly Phe Ser Ser Gly Ala Ser Glu Ile Glu 
        35                  40                  45              


Gly Asp His Leu Ser Asp Arg Thr Thr Asp Ile Ile Gln Gln Tyr Lys 
    50                  55                  60                  


Asn Arg Ser Phe Gly Leu Ser Leu Leu Lys Gln Thr Val Ile Ser Lys 
65                  70                  75                  80  


Asp Lys Leu Gln Lys Val His Cys Glu Lys Cys Lys Gly Lys Lys Pro 
                85                  90                  95      


Cys Glu Ala Cys Lys Lys Lys Tyr Glu His Lys Lys Val Ile Cys Ser 
            100                 105                 110         


Thr Leu Glu Arg Ile Phe Lys Pro Val Ile Glu Asp Val Ile Tyr Gly 
        115                 120                 125             


Lys Arg Ile Asp Tyr Asp Tyr Glu Asn Ile Lys Phe Ser Ser Gln Leu 
    130                 135                 140                 


Ser Leu Cys Lys Glu Glu Leu Ser Asn Phe Leu Cys His Lys Phe Arg 
145                 150                 155                 160 


Asp Thr Leu Arg Tyr Asn Asp Val Leu Lys Val Arg Arg Glu Val Asn 
                165                 170                 175     


Leu Ile Asp Cys Leu Gly Lys Phe Ile Asp Ser Lys Gly Arg Met Glu 
            180                 185                 190         


Ser Leu Arg Ala Tyr Cys Asp Trp Ala Glu Ala Tyr Ile Val Arg Lys 
        195                 200                 205             


Lys Ala Met Leu Glu Lys Ser Val Gln Asn Asn Arg Ile Val Phe Asp 
    210                 215                 220                 


Tyr Ser Glu Thr Glu Thr Thr Gly Leu Ser Lys Arg Lys Gln Ala Leu 
225                 230                 235                 240 


Leu Lys Trp Gly Lys Asp Tyr Glu Asp Lys Ser Arg Ser Asn Gln Gly 
                245                 250                 255     


Ala Ile Ser Pro Ile Asp Ala Ala Ser Ser Val His Tyr Asn Ile Asn 
            260                 265                 270         


Leu Asp Asp Phe His Arg Ala Phe Lys Ile Asp Asp Leu Cys Asn Ala 
        275                 280                 285             


Phe Ala Leu Thr Leu Glu Lys Gln Leu Ala Leu Leu Lys Glu Gln Glu 
    290                 295                 300                 


Glu Gln Lys His Lys Gln Pro Asn Leu Gln Asn Thr Tyr Ser Ala His 
305                 310                 315                 320 


Asn Gln Pro Thr Glu Thr Lys Thr Lys Leu Val Leu Thr Ser Ser Val 
                325                 330                 335     


Cys Ala Leu Leu Lys Lys Thr Leu Gln Glu His Gln Ala Thr Trp Val 
            340                 345                 350         


Phe Gly Arg Gln Ala Asp Leu Glu Lys Glu Asn Val Asp Pro Ala Arg 
        355                 360                 365             


Asp Ala Phe Ile Lys His Arg Asn Asp Cys Gln Leu Tyr Ala Tyr Asn 
    370                 375                 380                 


Leu Glu Val Val Lys Tyr Leu Glu His Tyr Phe Pro Ile Lys Arg Lys 
385                 390                 395                 400 


Lys Pro Leu Pro Asp Glu Glu Ser Ala Arg Tyr Tyr Leu Asn Pro Glu 
                405                 410                 415     


Thr Ile Lys Lys Arg Ile Gln Phe Gln Leu Glu Asn Ala Val Arg Met 
            420                 425                 430         


Gln Leu Leu Gln Gln Gly Lys Leu Lys His His Glu Leu Asp Glu Arg 
        435                 440                 445             


Val Asn Ser Glu Thr Leu Ser Ser Ile Lys Arg Asp Asp Phe Phe Val 
    450                 455                 460                 


Leu Asn Leu Val Glu Ala Cys Ala Phe Ala Ala Ser Asn Ile Arg Asn 
465                 470                 475                 480 


Ile Ile Asp His Glu Gln Lys Lys Asp Ile Leu Gly Lys Val Asp Phe 
                485                 490                 495     


Lys Asn Ser Leu Ala Ser Ala Arg Phe Asp Gly Glu Leu Cys Lys Tyr 
            500                 505                 510         


Phe Tyr Glu Thr Asn Leu Lys Thr Asp Cys Gln Ala Leu Trp Ala Met 
        515                 520                 525             


Arg Gly Ala Val Gln Gln Ile Arg Asn Gly Ile Val His Tyr His Lys 
    530                 535                 540                 


Gly Leu Ile Glu Ser Val Phe Lys Leu Asp Thr Phe Glu Tyr Glu Asn 
545                 550                 555                 560 


Ala Val Asp Ser Glu Lys Gln Tyr Thr His Thr Val Phe Lys Glu Leu 
                565                 570                 575     


Leu Gln Lys Ser Leu Ala Lys Leu Asp Gly Tyr Ile Val Glu Gln Phe 
            580                 585                 590         


Arg Ser Asn Asp Val Leu Ser Tyr Tyr Glu Ala Ser Asp Leu Asn Lys 
        595                 600                 605             


Leu Phe Gly Glu Gln Ser Leu Ser Leu His Arg His Ser Ile Pro Phe 
    610                 615                 620                 


Ala Pro Gly Phe Lys Asn Ile Tyr Asp Ser Gly Ala Lys Leu Gln Gln 
625                 630                 635                 640 


Gly Ser Thr Gly Met Arg Leu Asn His Phe Leu Leu Ala Glu Asn Asn 
                645                 650                 655     


Glu Ala Ser Leu Thr Arg Glu Gly Lys Glu Leu Ser Phe Ser Arg Lys 
            660                 665                 670         


Leu Ser Pro Ala Ala Thr Lys Leu Ser Pro Ala Tyr Pro Ala Phe Arg 
        675                 680                 685             


Phe Leu Leu Lys Leu Ile Tyr Asn His Leu Phe Leu Asn Phe Phe Leu 
    690                 695                 700                 


Asn Ser Glu Asp Asn Ala Ser Phe Arg Asn Ala Val Ala Phe Val Leu 
705                 710                 715                 720 


Lys Asn Asn Arg Glu Glu Ala Met Gln Ala Leu Arg Glu Ser Ala Lys 
                725                 730                 735     


Lys His Pro Gly Ser Arg Ser Ser Lys Pro Leu Leu Pro Gln Lys Tyr 
            740                 745                 750         


Ala Phe Arg Glu Ile Arg Gly Val Gln Asn Gly Glu Asp Ile Ala Ser 
        755                 760                 765             


Tyr Met Ser Tyr Leu His Ser Phe Ser Val Gln Glu Gln Glu Arg Lys 
    770                 775                 780                 


Gly Asp Gly Asn Glu Asn Gly Glu Thr Val Arg Arg Asn Thr Glu Lys 
785                 790                 795                 800 


Phe Leu Lys Gln Val Phe Val Lys Gly Phe Asp Thr Tyr Leu Ser Arg 
                805                 810                 815     


Leu Pro Leu His Phe Leu Tyr Thr Pro Asn Ile Glu Lys Val Gln Glu 
            820                 825                 830         


Asp Lys Asp His Tyr Val Asp Leu Asp Ile Lys Val Lys His Gln Ile 
        835                 840                 845             


Asp Cys Thr Lys Gly Ala His Ile Ser Phe Phe Ala Phe Cys Lys Leu 
    850                 855                 860                 


Leu Asp Gly Asn His Leu Ser Asp Leu Arg Asn Glu Leu Leu Lys Tyr 
865                 870                 875                 880 


Ser Ala Thr Ser Lys Ala Met Gly Ser Ser Val Glu Tyr Asn Phe Ala 
                885                 890                 895     


Phe Asp Val Ile Glu Leu Cys Leu Leu Asp Asn Asp Lys Arg Met Glu 
            900                 905                 910         


Phe Asp Lys Glu Gly Gln Val Val Asn Ser Asp Thr Lys Ser Lys Leu 
        915                 920                 925             


Cys Lys Gly Thr Tyr Lys Lys Leu Leu Ala Pro Phe Val Lys Gly Asp 
    930                 935                 940                 


Glu Lys Thr Asn Arg Ile Trp Met Ala Phe Tyr Phe Gln Ser Asp Lys 
945                 950                 955                 960 


Glu Thr Pro Val Asp Tyr Gly Ser Leu Ala Leu Ile Arg Lys Phe Gly 
                965                 970                 975     


Thr Gln Lys Leu Leu Glu Ala Leu Ile Thr Asp Glu Tyr Lys Val Thr 
            980                 985                 990         


Glu Gln Asp Tyr Asp Glu Trp Val  Ala Leu Lys Arg Asp  Ile Asp Lys 
        995                 1000                 1005             


Lys Val  Gln Glu Arg Glu Gln  Leu His Ala Glu Trp  Val Glu Ala 
    1010                 1015                 1020             


Gly Gly  Lys Phe Val Ser Glu  Ser Asn Thr Asp Val  Tyr Phe Lys 
    1025                 1030                 1035             


Leu Cys  Lys Asp Ile Glu Arg  Tyr Asn Trp Leu Asp  Asn Lys Leu 
    1040                 1045                 1050             


His Leu  Val His Leu Lys Gln  Leu His Asn Phe Ile  Ile Gln Ile 
    1055                 1060                 1065             


Leu Ser  Arg Met Ala Arg Phe  Val Ala Met Arg Asp  Arg Asp Leu 
    1070                 1075                 1080             


Ala Phe  Val Lys Glu Leu Arg  Phe Pro Ala Tyr His  Lys Ser Phe 
    1085                 1090                 1095             


Phe Met  Gln Asp Asp Thr Leu  Lys Glu Cys Arg Asn  Tyr Ile Ala 
    1100                 1105                 1110             


His Phe  Asn Tyr Val Thr Thr  Thr Ala Ser Ser Ser  Leu Ile Asp 
    1115                 1120                 1125             


Ile Leu  Asn Ser Leu Arg Glu  Leu Met Ala Tyr Asp  Arg Lys Leu 
    1130                 1135                 1140             


Arg Asn  Ala Val Thr Lys Ser  Ile Ile His Val Phe  Lys Gln Asn 
    1145                 1150                 1155             


Gly Met  Asn Leu Gln Leu Gly  Trp Val Asp Asn Gly  Arg Lys Ser 
    1160                 1165                 1170             


Asp Ser  Ile His Arg Leu Met  Val Lys Ser Val Lys  Ser Glu Pro 
    1175                 1180                 1185             


Ile Lys  Leu Leu Lys Ala Glu  Leu Thr Ile Asp Gln  Val Pro Glu 
    1190                 1195                 1200             


Glu Tyr  Cys Arg Leu Cys Lys  Trp Leu Leu Glu Met  Lys Lys 
    1205                 1210                 1215         


<210>  113
<211>  982
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  113

Met Lys Ile Ser Lys Val Asn His Val Lys Thr Gly Val Ser Ala Lys 
1               5                   10                  15      


Pro Ala Ile Glu Gly Gly Met Leu Tyr Asp Tyr Pro Ser Lys Glu Gly 
            20                  25                  30          


Gly Ser Lys Asp Leu Arg Lys His Ile Glu Glu Val Asn Arg Lys Ala 
        35                  40                  45              


Gln Ile Leu Tyr Asn Val Phe Asn Gln Val Lys Glu Lys Asp Lys Lys 
    50                  55                  60                  


Gln Asn Ser Val Lys Asp Ala Leu Lys Ile Ala Asn Ala Tyr Ile Asn 
65                  70                  75                  80  


Ser Thr Val Ile Phe Gly Ile Lys Lys Glu Phe Pro Glu Asn Lys Ile 
                85                  90                  95      


Cys Asn Asn Phe Ser Tyr Ala Val Asn Arg Pro Ile Arg Leu Gly Lys 
            100                 105                 110         


Glu Asn Val Phe Ile Thr Ser Ile Ser Val Ser Val Lys Glu Lys Ser 
        115                 120                 125             


Ala Lys Glu Ser Ala Glu Tyr Ile Val Asn Asn Tyr Leu Arg Asn Ser 
    130                 135                 140                 


Leu Arg Arg Asp Lys Arg Ala Ala Glu Thr Ile Val Arg Ile Leu Thr 
145                 150                 155                 160 


Ala Leu Tyr Asp Gly Lys Asn Tyr Glu Lys Leu Ile Lys Lys Ile Glu 
                165                 170                 175     


Arg Glu Asp Leu Ala Ala Val Val Ser Ala Val Ser Arg Asp Tyr Leu 
            180                 185                 190         


Lys Asp Gly Glu Leu Glu Lys Ile Ala Val Ser Ile Glu Lys Gln Lys 
        195                 200                 205             


Val Leu Val Gln Val Gly Lys Asp Gly Tyr Leu Ile Pro Ser Gly Ala 
    210                 215                 220                 


Glu His Glu Lys Lys Ala Tyr Ile Phe Asn Phe Met Lys Lys Tyr Ala 
225                 230                 235                 240 


Glu Ser Asp Glu Glu Gly Gln Arg Lys Met Leu Asn His Met Lys Asp 
                245                 250                 255     


Leu Ile Arg Leu Tyr Tyr Thr Glu Glu Glu Val Val Ser Ser Glu Ile 
            260                 265                 270         


Leu Asp Leu Ile Asn Ser Arg Asp Asn Thr Pro Phe Ser Gln Lys Asp 
        275                 280                 285             


Ile Ile Arg Ser Tyr Asn Glu Gln Ile Ala Glu Lys Val Ser Ala Phe 
    290                 295                 300                 


Leu Val Glu Arg Tyr Gln Lys Thr Leu Lys Asp Ala Lys Ser Glu Asp 
305                 310                 315                 320 


Glu Glu Gly Trp Val Arg Tyr Ile Ser Asp Lys Ala Glu Lys Leu Leu 
                325                 330                 335     


Ser Val Lys Asn Leu Thr Gln Asp Arg Ile His Cys Asp Tyr Leu Phe 
            340                 345                 350         


Lys Lys Thr Trp Glu Glu Trp Thr Ser Phe Ile Ala Lys Lys Tyr Ile 
        355                 360                 365             


Asp Leu Gly Lys Ala Thr Tyr Asn Phe Ala Met Gly Asp Ile Ser Lys 
    370                 375                 380                 


Val Ser Lys Gly Glu Ser Val Ala Phe Gly Thr Val Asn Glu Gly Phe 
385                 390                 395                 400 


Glu Thr Gly Ile Ser Ser Phe Asp Tyr Glu Arg Met Lys Ala Glu Asp 
                405                 410                 415     


Ser Leu Asn Arg Ala Met Ile Lys Tyr Ile Ser Phe Ala Val Asn Ile 
            420                 425                 430         


Phe Asp Ala Ser Val Arg Asn Pro Glu Gln Arg Thr Gly Gly Lys Glu 
        435                 440                 445             


Asp Ile Leu Leu Leu Lys Pro Glu Asn Ile Val Met Tyr Glu Asp Ala 
    450                 455                 460                 


Val Lys Arg Val Leu Arg Tyr Phe Gly Gly Ile Ser Lys Phe Ser Glu 
465                 470                 475                 480 


Ser Ser Leu Asp Val Ser Asp Lys Asn Gly Phe Phe Thr Ala Leu Lys 
                485                 490                 495     


Asp Glu Leu Tyr Ala Ala Arg Asn Tyr Ala Phe His Tyr Val Thr Gly 
            500                 505                 510         


Glu Ala Glu Lys Arg Glu Lys Pro Val Val Thr Thr Leu Leu Asp Thr 
        515                 520                 525             


Glu Tyr Met Leu Val Gly Ser Ile Phe Arg Lys Lys Tyr Phe Ser Asn 
    530                 535                 540                 


Asn Val Pro Met Phe Tyr Arg Thr Ala Asp Ile Asp Asn Leu Met Ser 
545                 550                 555                 560 


Arg Leu Tyr Lys Ser Asn Arg Val Ile Leu Ala Gln Met Pro Ser Phe 
                565                 570                 575     


Asn Lys Val Leu Ser Arg Asn Ala Val Val Asp Phe Ala Asn Ala Tyr 
            580                 585                 590         


Leu Ala Gly Asp Ser Lys Arg Glu Met Ser Gln Pro Glu Ile Ser Glu 
        595                 600                 605             


Gln Phe Arg Ser Ser Phe Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Tyr 
    610                 615                 620                 


Asp Phe Ile Leu Lys Glu Asp Leu Leu Glu Arg Phe Lys Asn Gly Val 
625                 630                 635                 640 


Glu Cys Ala Gln Ala Ser Ala Ile Lys Lys Glu Asn Asn Ser Arg Lys 
                645                 650                 655     


His Val Ala Met Lys Asn Ala Tyr Arg Asp Phe Met Ser Arg Ala Asp 
            660                 665                 670         


Lys Leu Thr Lys Thr Lys Gly Ile Thr Phe Gly Gln Phe Cys Gln Glu 
        675                 680                 685             


Ile Met Thr Glu Tyr Asn Gln Gln Asn Ser Gln Lys Gln Lys Lys Pro 
    690                 695                 700                 


Ser Ala Val Glu Lys Thr Tyr Val Val Lys Gly Gln Thr Arg Thr Ser 
705                 710                 715                 720 


Val Arg Glu Val Glu Asp Lys Glu Gln Ile Tyr Lys His Tyr Arg Thr 
                725                 730                 735     


Leu Leu Tyr Ala Gly Ile Arg Glu Ala Phe Leu Ile Tyr Leu Lys Glu 
            740                 745                 750         


Glu Ala Ala Phe Gly Phe Leu Arg Ser Pro Lys Asp Gly Arg Glu Lys 
        755                 760                 765             


Phe Arg Asp Leu Lys Glu Glu Asp Phe Ser Gln Gly Trp Thr Thr Glu 
    770                 775                 780                 


Cys Tyr Thr Lys Leu Lys Asp Ala Ile Ile Glu Asp Lys Glu Leu Ser 
785                 790                 795                 800 


Ser Trp Tyr Val Thr Ala His Phe Met Asn Gln Lys His Leu Asn His 
                805                 810                 815     


Leu Ile Gly Glu Ile Lys Asn Tyr Val Gln Phe Ile Asp Asp Ile Glu 
            820                 825                 830         


Lys Arg Ala Lys Val Thr Gly Asn Arg Val Cys Ser Thr Glu Glu Lys 
        835                 840                 845             


Met Gly Lys Phe Thr Ser Leu Leu Glu Val Leu Glu Phe Cys Lys Leu 
    850                 855                 860                 


Phe Cys Gly Gln Val Ser Asn Asn Leu Glu Asp Tyr Phe Ala Asn Asn 
865                 870                 875                 880 


Glu Glu Tyr Ala Lys Tyr Val Ala Gly Phe Val Asp Tyr Gly Gly Thr 
                885                 890                 895     


Ser Ala Ala Leu Leu Gln Ala Phe Cys Arg Glu Asn Lys Glu Leu Asn 
            900                 905                 910         


Tyr Tyr Asp Glu Leu Asn Pro Ile Pro Asn Arg Asn Ile Ile Leu Ser 
        915                 920                 925             


Leu Leu Tyr Gly Asn Thr Ala Val Leu Ser Ser Ser Met Lys Lys Val 
    930                 935                 940                 


Thr Leu Gln Glu Val Lys Gly Tyr Gln Lys Asn Lys Glu Ser Leu Ser 
945                 950                 955                 960 


Gly Val Phe Lys Asn Gly Ala Cys Lys Asp Glu Asn Glu Gln Arg Lys 
                965                 970                 975     


Met Ser Asn Tyr Gln Lys 
            980         


<210>  114
<211>  1425
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  114

Met Lys Leu Ser Lys Val Asp Arg Ile Arg Val Ala Val Gly Lys Thr 
1               5                   10                  15      


Gly Lys Thr Glu Asn Gly Asn Ser Gln Gly Arg Gly Val Leu Tyr Arg 
            20                  25                  30          


Ser Pro Lys Gly Asn Lys Thr Val Ala Val Asp Ala Val Val Glu Glu 
        35                  40                  45              


Arg Ile Arg Asn Ala Asn Arg Leu Tyr Ser Ala Phe Phe Arg Cys Ala 
    50                  55                  60                  


Tyr Pro Glu Glu Pro Glu Arg His Phe Glu Glu Ile Ile Lys Arg Met 
65                  70                  75                  80  


Ala Thr Gly Lys Lys Ser Gly Ala Gln Ile Leu Lys Glu Tyr Ile Gly 
                85                  90                  95      


Tyr Glu Gly Gln Lys Asn Arg Lys Pro Tyr Thr Phe Tyr Val Asn Lys 
            100                 105                 110         


Cys Ala Tyr Arg Pro Ala Gly Lys Glu Leu Gly Gln Val Leu Arg Leu 
        115                 120                 125             


Phe Val Lys Glu Arg Leu Gly Gln Asn Trp Gln Asn Pro Glu Ala Ala 
    130                 135                 140                 


Glu Ala Ala Val Ala Leu Leu Thr Cys Leu Cys Glu Gly Lys Thr Asn 
145                 150                 155                 160 


Arg Tyr Thr Glu Asn Thr Ala Asp Gly Pro Val Leu Thr Glu Leu Ser 
                165                 170                 175     


Glu Gln Thr Val Thr Gln Leu Glu Gln Val Ser Arg Leu Gly Gly Ser 
            180                 185                 190         


Ile Leu Val Pro Lys Thr Glu Arg Leu Glu Thr Ile Val Thr Val Ile 
        195                 200                 205             


Leu Arg Leu Thr Ala Glu Gln Cys Asn Thr Ser Leu Tyr Val Asn Gly 
    210                 215                 220                 


Gly Thr Lys Glu Ala Gln Asp Ala Asp Leu Glu Lys Gln Ile Ala Leu 
225                 230                 235                 240 


Leu Lys Ser Leu Gln Thr Lys Pro Leu Leu Leu Lys Glu Arg Phe Asp 
                245                 250                 255     


Lys Val Thr Lys Gln Thr Ile Arg Asp Glu Gln Lys Leu Ser Glu Phe 
            260                 265                 270         


Ser Tyr Lys Asp Ala Thr Lys Glu Arg Met Glu Ala Val Val Val Arg 
        275                 280                 285             


Met Arg Lys Thr Leu Lys Lys Gly Ala Ser Arg Glu Val Ala Val Glu 
    290                 295                 300                 


Leu Leu Gln Ala Leu Ala Gln Tyr Asp Gly Lys Thr Trp Asp Gly Trp 
305                 310                 315                 320 


Leu Thr Gln Met Leu Glu Thr Glu Ala Ser Lys Lys Lys Leu Lys Asp 
                325                 330                 335     


Phe Ile Leu Ala Val Asn Lys Asp Phe His His Phe His Val Ile Lys 
            340                 345                 350         


Ser Val Lys Asn Thr Ala Val Ala Val Ser His Ser Glu Asp Asn Thr 
        355                 360                 365             


Leu Gln Leu Ser Gly Ala Lys Lys Lys Thr Lys Gly Ala Met Gln Asp 
    370                 375                 380                 


Ala Leu Phe Ala Tyr Ala Gln Ser Glu Glu Ser Ser Asp Glu Thr Leu 
385                 390                 395                 400 


His Arg Ile Lys Arg Ile Leu Phe Thr Tyr Val Leu Gly Gly Arg Gln 
                405                 410                 415     


Asp Asn Thr Leu Arg Leu Thr Glu Lys Thr His Leu Ala Lys Glu Leu 
            420                 425                 430         


Leu Trp Lys Phe Arg Gly Thr Gly Ala Gly Leu Phe Asp Ala Asp Phe 
        435                 440                 445             


Val Pro Glu Glu Glu Arg Ala Gly Glu Ser Gly Arg Lys Ala Gly Ser 
    450                 455                 460                 


Tyr Thr Asp Leu Gly Cys Leu Phe Ala Glu Asp Asp Gly Ile Arg Asn 
465                 470                 475                 480 


Gln Arg Arg Ile Ala Asp Arg Ile Asn Tyr Val Asn Tyr Gly Asn Tyr 
                485                 490                 495     


Leu Arg Met Arg Lys Ala Ala Glu Asp Glu Phe Thr Leu Phe Trp Cys 
            500                 505                 510         


Ala Tyr Ile Lys Asp Tyr Ile Glu Glu Asn Tyr Val Thr Lys Ile Arg 
        515                 520                 525             


Glu Ala Lys Arg Thr Gly Gly Lys Arg Arg Leu Lys Glu Thr Asp Cys 
    530                 535                 540                 


Glu Ala Glu Arg Met Met Glu Lys Cys Trp His Asp Ile Ile Arg Tyr 
545                 550                 555                 560 


Ile Cys Gly Lys Tyr Ile His Ile Gly Lys Ala Val Tyr His Phe Ala 
                565                 570                 575     


Ile Pro Glu Asp Leu Leu Ala Asn Pro Gly Glu Val Arg Ser Phe Gly 
            580                 585                 590         


Asp Val His Ala Lys Tyr Ala Asp Gly Ile Thr Ser Phe Asp Tyr Glu 
        595                 600                 605             


Asp Ile Lys Ala Glu Glu Asn Leu Gln Lys Ser Ile Phe Asn Val Leu 
    610                 615                 620                 


Val Ser Ala Val Ala Asn Tyr Ser Arg Ser Val Val Asp Leu Ser Ser 
625                 630                 635                 640 


Glu Arg Ala Glu Glu Leu Arg Arg Leu Pro Gly Asn Glu Arg Leu Asn 
                645                 650                 655     


Glu Asp Val Leu Met Met Lys Glu Thr His Leu Lys Glu Leu Leu Leu 
            660                 665                 670         


Pro Asp Ala Lys Lys Arg Leu Leu Arg Tyr Phe Gly Gly Tyr Ser Ala 
        675                 680                 685             


Cys Glu Gly Leu Ser Gly Val Thr Ser Glu Glu Leu Ala Trp Glu Met 
    690                 695                 700                 


Arg Thr Val Leu Ser Thr Leu Arg Asn Glu Ser Phe His Tyr Thr Phe 
705                 710                 715                 720 


Gly Lys Lys Lys Lys Leu Asp Tyr Lys Val Ala Lys Gln Leu Trp Met 
                725                 730                 735     


Gln Ala Ile Arg Ala Asn Arg Gln Leu Ile Leu Asp Lys Tyr Tyr Ser 
            740                 745                 750         


Asn Asn Thr Cys Arg Tyr Tyr Ser Pro Asn Ser Ile Lys Ala Leu Ile 
        755                 760                 765             


Glu Gln Gly Tyr Arg Ser Tyr Glu Glu Arg Glu Ala Gln Ile Pro Ala 
    770                 775                 780                 


Phe Lys Thr Val Trp Lys Lys Ala Glu Leu Ala Lys Tyr Leu Ala Asp 
785                 790                 795                 800 


Lys Lys Val Met Pro Ala Glu Ile Ser Gly Glu Glu Lys Glu Arg Val 
                805                 810                 815     


Ile Phe Gln Gly Ala Phe Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg 
            820                 825                 830         


Glu Phe Thr Val Gly Asn Thr Ala Ala Lys Tyr Phe Phe Asp Ala Val 
        835                 840                 845             


Glu Arg Tyr Cys Lys Glu Asn Glu Thr Gly Pro Tyr Lys Asn Pro Ala 
    850                 855                 860                 


Lys Ser Phe Asn Asp Tyr Val Asn Gly Ala Phe Asn Asn Lys Gly Val 
865                 870                 875                 880 


Lys Val Gln Lys Gly Leu Ser Asp Leu Tyr Arg Glu Gly Lys Ile Thr 
                885                 890                 895     


Phe Gly Val Val Cys Gln Thr Ile Met Ala Glu Tyr Thr Gln Gln Asn 
            900                 905                 910         


Glu Lys Ser Glu Gly Glu Ala Ile Tyr Gln His Phe Lys Met Leu Phe 
        915                 920                 925             


Pro Leu Cys Met Arg Lys Gly Phe Gln Lys Tyr Val Glu Glu Lys His 
    930                 935                 940                 


Lys Glu Leu Leu Gln Pro Val Ile Arg Glu Met Gly Ser Arg Glu Asp 
945                 950                 955                 960 


Phe Leu Thr Asn Ile His Ile Gly Cys Phe Asp Asp Phe Cys Arg Glu 
                965                 970                 975     


Asp Gly Met Tyr Glu Tyr Asp Trp Phe Val Val Ala His Leu Ile His 
            980                 985                 990         


Pro Lys Arg Leu Asn Glu Leu Val  Gly Asn Leu Lys Asp  Tyr Met Gln 
        995                 1000                 1005             


Phe Lys  Gln Asp Ile Leu Arg  Arg Ala Asp Tyr Val  Glu Gln Phe 
    1010                 1015                 1020             


Thr Lys  Glu Glu Leu Ala Ala  Met Lys Ala Arg Thr  Glu Glu Lys 
    1025                 1030                 1035             


Leu Gln  Lys Ile Ser Gly Ile  Leu Arg Val Ala Glu  Phe Val Arg 
    1040                 1045                 1050             


Gly Ile  Ala Gly Arg Val Ser  Asn Thr Phe Ser Asp  Tyr Tyr Glu 
    1055                 1060                 1065             


Ser Glu  Glu Ala Tyr Ala Ser  Tyr Leu Glu Gln Tyr  Ile Glu Phe 
    1070                 1075                 1080             


Pro Arg  Ile Lys Gly Ser Thr  Val Phe Glu Ser Phe  Arg Asp Phe 
    1085                 1090                 1095             


Cys Val  Asn Thr Leu Pro Gly  Gly Ala Val Met Asp  Val Tyr Met 
    1100                 1105                 1110             


Asp Glu  Lys Asn Pro Arg Ile  Leu Arg Asn Val Glu  Val Ala Arg 
    1115                 1120                 1125             


Met Tyr  Ala Gly Gly Asp Ile  Gly Leu Arg Thr Arg  Lys Lys Val 
    1130                 1135                 1140             


Thr Ala  Glu Glu Leu Lys Arg  Tyr Tyr Gln Asn Glu  Ala Glu Val 
    1145                 1150                 1155             


Ala Ala  Leu Leu Lys Ala Gly  Leu Cys Ala Thr Ala  Glu Asp Gln 
    1160                 1165                 1170             


Lys Arg  Val Lys Ala Gln Gln  Glu Leu Arg Asn Arg  Ile Thr Leu 
    1175                 1180                 1185             


Thr Asp  Val Thr Glu Ile Gln  Glu Val Ile Asn Asp  Leu Leu Ser 
    1190                 1195                 1200             


Gln Leu  Val Thr Phe Ser Tyr  Phe Arg Glu Arg Asp  Glu Met Tyr 
    1205                 1210                 1215             


Leu Leu  Leu Gly Phe Tyr Tyr  Met Ala Leu Gln Ser  Asp Gly Asp 
    1220                 1225                 1230             


Trp Gly  Glu Glu Leu Arg Val  Phe Asp Gly Lys Lys  Leu Gln Val 
    1235                 1240                 1245             


Glu Asn  Gly Phe Val Leu Tyr  Gln Leu Leu Ser Ala  Phe Thr Tyr 
    1250                 1255                 1260             


Gly Leu  Asn Met Tyr Ser Glu  Ala Ala Pro Asp Gly  Lys Gly Gly 
    1265                 1270                 1275             


Ser Gln  Ala Gly Lys Ile Gly  Glu Phe Ile Lys Ala  His Pro Asn 
    1280                 1285                 1290             


Ser Trp  Asp Arg Ala Leu Arg  Leu Phe Val Asp Asp  Gly Ala Cys 
    1295                 1300                 1305             


Glu Glu  Val Ser Arg Lys Ala  Arg Asn Tyr Val Asp  His Phe Arg 
    1310                 1315                 1320             


Tyr Tyr  Val Lys Pro Asp Arg  Ser Ile Met Asp Leu  Tyr Ala Val 
    1325                 1330                 1335             


Tyr His  Glu Tyr Phe Phe Asp  Tyr Ser Thr Lys Met  Arg Lys Ser 
    1340                 1345                 1350             


Val Leu  Gln Asn Phe Ala Ser  Ile Leu Glu Arg Tyr  Phe Val Leu 
    1355                 1360                 1365             


Thr Lys  Phe Lys Leu Gly Gly  Glu Arg Gly Ala Gln  Thr Leu Glu 
    1370                 1375                 1380             


Ala Glu  Leu Ser Gly Asp Lys  Phe Thr Tyr Lys Leu  Ser Asp Thr 
    1385                 1390                 1395             


Lys Ala  Lys Pro Val Val Leu  Pro Ala Arg Asn Lys  Glu Phe Leu 
    1400                 1405                 1410             


Glu Asn  Leu Lys Asn Glu Leu  Asn Tyr Arg Gln Glu  
    1415                 1420                 1425 


<210>  115
<211>  1380
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  115

Met Lys Leu Ser Lys Glu Lys Gln Ile Arg Ser Ala Val Ala Asn Lys 
1               5                   10                  15      


Glu Lys Asn Thr Glu Gly Val Leu Tyr Arg Phe Pro Gly Asp Asp Ile 
            20                  25                  30          


Gly Gly Val Gln Ala Gln Met Leu Val Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Leu Gly Asn Lys Pro Lys Glu 
    50                  55                  60                  


Trp Met Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Lys Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Ala Ile Asn Asp Ile Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Lys Glu Ala Asp Lys Lys Ile Arg Asn Met Ser Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Asn Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Ser Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Gly Asn Gln Glu Phe Asp Ser Ile Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Asp Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Ser Ile Gln Asp Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Ile Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Glu Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Asp Gly Leu Asn Glu Phe Met Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Glu Glu Lys Arg Ala Glu Val Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Ser His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Val Asn Lys Gly Lys Phe Tyr Val Trp 
305                 310                 315                 320 


Lys Lys His Glu Cys Gly Lys Lys Glu Asn Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Val Glu Ala Glu Ala Glu Ser Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Ile Phe Phe Glu Asn Asp Thr Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Thr Gly Thr Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Lys Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asn Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Gln Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Tyr Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Leu 
            660                 665                 670         


Val Arg Thr Val Phe Pro Glu Tyr Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Asn Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Arg Thr Leu Arg Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Lys 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Glu Asn Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Cys Ala Gln Asp 
            900                 905                 910         


Ile Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu 
        915                 920                 925             


Leu Ser Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Lys Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Lys Phe Ser Glu Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Thr Asn Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Gly  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Glu Lys Pro Glu  Glu Tyr Glu Lys Ile  Glu Ala Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Ile  Tyr Ala Pro Glu Lys  Asn Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Gln Gly Arg Val Gly  Ala Lys Val 
    1145                 1150                 1155             


Thr Ser  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Glu Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Met Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Val Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Val Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Glu Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asn Ala 
    1280                 1285                 1290             


Lys Asp  Lys Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Asp  Ala Glu Asp Ala Asp  Ser Lys Lys Pro Val  Ile Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Glu  Asp Glu Asp 
    1325                 1330                 1335             


Lys Gln  Lys Gly Lys Glu Asn  Arg Gly Lys Lys Asn  Thr Glu Thr 
    1340                 1345                 1350             


Arg Ser  Asp Ala Glu Lys Asn  Asn Asn Glu Arg Leu  Ser Tyr Asn 
    1355                 1360                 1365             


Pro Phe  Ala Asn Phe Asp Phe  Lys Leu Pro Asn Lys  
    1370                 1375                 1380 


<210>  116
<211>  1143
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  116

Met Arg Ile Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Val Tyr Ser Gly 
            20                  25                  30          


Gln Pro Val Ser Asn Glu Thr Cys Asn Ile Leu Pro Glu Lys Lys Arg 
        35                  40                  45              


Gln Ser Phe Asp Leu Ser Ile Glu Asn Lys Thr Leu Lys Arg Arg Asp 
    50                  55                  60                  


Asp Val Asp Lys Thr Lys Lys Gly Lys Tyr Asp Ile Val Arg Lys Ile 
65                  70                  75                  80  


Ile Lys Tyr Gly Glu Leu Pro Gln Ser Ile Asn Asp Val Asp Ile Leu 
                85                  90                  95      


Glu Phe Leu Asn His Lys Phe Gln Lys Pro Val Lys Tyr Trp Lys Asn 
            100                 105                 110         


Gly Lys Glu Glu Ser Phe Asn Leu Thr Leu Leu Ile Val Glu Ala Val 
        115                 120                 125             


Lys Thr Gln Asp Arg Gln Lys Leu Gln Pro Tyr Tyr Asp Trp Lys Thr 
    130                 135                 140                 


Trp Tyr Ile Gln Thr Lys Ser Asp Leu Leu Lys Lys Ser Ile Glu Asn 
145                 150                 155                 160 


Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg Lys Lys Ala Leu 
                165                 170                 175     


Leu Ala Trp Glu Thr Glu Phe Thr Thr Ser Gly Lys Ile Asp Leu Thr 
            180                 185                 190         


His Tyr His Lys Val Tyr Met Thr Asp Val Leu Cys Thr Ala Leu Gln 
        195                 200                 205             


Lys Val Glu Pro Ser Thr Asp Lys Lys Gly Lys Ile Asn Thr Asn Ala 
    210                 215                 220                 


Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Thr His Gln Pro Ala Ile 
225                 230                 235                 240 


Phe Gly Thr Arg Gln Ala Pro Asn Asn Val Asn Arg Ala Asp Asp Arg 
                245                 250                 255     


Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu Glu His Tyr Phe 
            260                 265                 270         


Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Ala Asp Asp Ile Glu His 
        275                 280                 285             


Tyr Leu Lys Thr Gln Thr Leu Lys Thr Thr Ile Glu Lys Gln Met Val 
    290                 295                 300                 


Asn Ala Ile Arg Ala Asn Ile Ile Gln Gln Gly Lys Thr Asn His His 
305                 310                 315                 320 


Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile Arg Ile Lys Thr 
                325                 330                 335     


Asn Glu Ala Phe Val Leu Asn Leu Thr Gly Thr Cys Ala Phe Ala Ala 
            340                 345                 350         


Asn Asn Ile Arg Asn Met Val Asp Asn Glu Gln Thr Asn Asp Ile Leu 
        355                 360                 365             


Gly Lys Gly Asp Phe Ile Lys Ser Leu Leu Lys Asp Asn Thr Asn Gly 
    370                 375                 380                 


Gln Leu Tyr Ser Phe Phe Phe Gly Glu Ser Leu Ser Thr Asn Lys Ala 
385                 390                 395                 400 


Glu Lys Glu Thr Gln Leu Trp Gly Ile Arg Gly Ala Val Gln Gln Ile 
                405                 410                 415     


Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu Lys Thr Val Phe 
            420                 425                 430         


Asn Ile Ser Asn Phe Glu Asn Pro Thr Ile Thr Asp Pro Lys Gln Gln 
        435                 440                 445             


Thr Asn Tyr Ala Asp Thr Ile Tyr Lys Ala Leu Phe Ile Lys Glu Leu 
    450                 455                 460                 


Glu Lys Ile Pro Asn Ala Phe Ala Gln Gln Leu Lys Thr Gly Gly Ala 
465                 470                 475                 480 


Leu Ser Tyr Tyr Thr Ile Glu Asn Leu Lys Ser Leu Leu Thr Thr Phe 
                485                 490                 495     


Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala Pro Gly Phe Lys 
            500                 505                 510         


Lys Val Phe Asn Gly Gly Ile Asn Tyr Gln Asn Ala Lys Gln Asp Glu 
        515                 520                 525             


Ser Phe Tyr Glu Leu Met Leu Glu Arg Tyr Leu Arg Lys Glu Asn Phe 
    530                 535                 540                 


Ala Glu Glu Ala Tyr Asn Ala Arg Tyr Phe Leu Leu Lys Leu Ile Tyr 
545                 550                 555                 560 


Asn Asn Leu Phe Leu Pro Gly Phe Thr Arg Asp Arg Lys Ala Phe Ala 
                565                 570                 575     


Asp Ser Val Gly Phe Val Gln Met Gln Asn Lys Lys Gln Ala Glu Lys 
            580                 585                 590         


Val Asn Pro Lys Lys Arg Glu Ala Tyr Ala Phe Glu Ala Val Arg Pro 
        595                 600                 605             


Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala Tyr Val Gln Ser 
    610                 615                 620                 


Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys Ala Thr Asp Glu 
625                 630                 635                 640 


Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val Phe Val Lys Gly 
                645                 650                 655     


Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe Val Gln Val Pro 
            660                 665                 670         


Gln Pro Gln Leu Thr Ala Thr Ala Ser Asn Gln Gln Lys Ala Asp Lys 
        675                 680                 685             


Leu Asn Gln Leu Glu Ala Ser Ile Thr Ala Asp Cys Lys Leu Thr Pro 
    690                 695                 700                 


Gln Tyr Ala Lys Ala Asp Asn Ala Thr His Ile Ala Phe Tyr Val Phe 
705                 710                 715                 720 


Cys Lys Leu Leu Asp Ala Gly His Leu Ser Asn Leu Arg Asn Glu Leu 
                725                 730                 735     


Ile Lys Phe Arg Glu Ser Val Asn Glu Phe Lys Phe His His Leu Leu 
            740                 745                 750         


Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val Val Pro Thr Asp 
        755                 760                 765             


Tyr Arg Asp Leu Tyr Ser Ser Glu Ala Asp Cys Leu Ala Arg Leu Arg 
    770                 775                 780                 


Pro Phe Ile Glu Gln Gly Ala Asp Ile Thr Asn Trp Ser Asp Leu Phe 
785                 790                 795                 800 


Val Gln Ser Asp Lys His Ser Pro Val Ile His Ala Asn Ile Glu Leu 
                805                 810                 815     


Ser Val Lys Tyr Gly Thr Thr Lys Leu Leu Glu Gln Ile Ile Asn Lys 
            820                 825                 830         


Asp Pro Gln Phe Lys Thr Thr Glu Ala Asn Phe Thr Ala Trp Asn Thr 
        835                 840                 845             


Ala Gln Lys Ser Ile Glu Gln Leu Ile Lys Gln Arg Glu Asp His His 
    850                 855                 860                 


Glu Gln Trp Val Lys Ala Lys Asn Ala Asp Asp Lys Glu Lys Gln Glu 
865                 870                 875                 880 


Arg Lys Arg Glu Lys Ser Asn Phe Ala Gln Lys Phe Ile Glu Lys His 
                885                 890                 895     


Gly Asp Asp Tyr Leu Asp Ile Cys Asp Tyr Ile Asn Thr Tyr Asn Trp 
            900                 905                 910         


Leu Asp Asn Lys Met His Phe Val His Leu Asn Arg Leu His Gly Leu 
        915                 920                 925             


Thr Ile Glu Leu Leu Gly Arg Met Ala Gly Phe Val Ala Leu Phe Asp 
    930                 935                 940                 


Arg Asp Phe Gln Met Leu Asp Ala Lys Arg Ile Ser Asp Leu Tyr Gln 
945                 950                 955                 960 


Leu Lys Ser Phe Ile Ser Phe Arg Glu Ile Thr Ser Glu Leu Asp Lys 
                965                 970                 975     


Asn Asn Asp Ile Thr Glu Ile Asn Leu Ile Lys Asp Lys Glu Ile Ile 
            980                 985                 990         


Lys Arg Asp Gly Thr Pro Ile Thr  Glu Ala Asp Arg Asn  Ser Leu Lys 
        995                 1000                 1005             


Ser Cys  Ile Gln Ser Lys Arg  Glu Tyr Tyr Gln Lys  Thr Tyr Phe 
    1010                 1015                 1020             


Lys Glu  His Thr Asn Pro Phe  Thr Asp Arg Asn Tyr  Ile Ala His 
    1025                 1030                 1035             


Phe Asn  Tyr Leu Ser Thr Asn  Thr Gly Asn His Ser  Leu Ile Lys 
    1040                 1045                 1050             


Leu Ile  Asn Lys Leu Arg Asp  Leu Leu His Tyr Asp  Arg Lys Leu 
    1055                 1060                 1065             


Lys Asn  Ala Val Ser Lys Ala  Phe Ile Asp Leu Phe  Asp Lys His 
    1070                 1075                 1080             


Gly Met  Ile Leu Lys Leu Lys  Leu Asn Thr Asp His  Gln Leu Glu 
    1085                 1090                 1095             


Val Glu  Ser Leu Glu Pro Lys  Lys Ile Tyr His Leu  Gly Ser Ser 
    1100                 1105                 1110             


Ala Lys  Asp Lys Pro Glu Tyr  Gln Tyr Cys Thr Asn  Gln Val Met 
    1115                 1120                 1125             


Met Ala  Tyr Cys Asn Met Cys  Arg Ser Leu Leu Glu  Met Lys Lys 
    1130                 1135                 1140             


<210>  117
<211>  1384
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  117

Met Gly Asn Leu Phe Gly His Lys Arg Trp Tyr Glu Val Ser Asp Arg 
1               5                   10                  15      


Glu Asn Tyr Lys Ile Lys Arg Lys Val Lys Val Lys Arg Asn Tyr Asp 
            20                  25                  30          


Gly Asn Lys Tyr Ile Leu Asn Ile Asn Glu Asn Asn Asn Lys Glu Lys 
        35                  40                  45              


Ile Asp Asn Asn Glu Phe Ile Glu Glu Leu Val Asn Tyr Lys Lys Asn 
    50                  55                  60                  


Asn Asn Val Leu Arg Glu Phe Lys Arg Lys Phe His Ala Arg Asn Ile 
65                  70                  75                  80  


Leu Phe Lys Leu Lys Gly Asn Lys Arg Ser Ile Glu Asp Ser Asn Asp 
                85                  90                  95      


Phe Leu Lys Thr Glu Glu Val Val Leu Asp Lys Glu Ile Tyr Gly Gln 
            100                 105                 110         


Ser Glu Lys Leu Arg Asn Glu Lys Gly Ile Thr Lys Lys Asp Ile Leu 
        115                 120                 125             


Lys Glu Ile Asn Lys Gln Lys Ile Asp Asn Ser Val Lys Lys Ile Ser 
    130                 135                 140                 


Met Asn Thr Asn Ser Gly Lys Thr Ile Val Ile Asn Phe Ser Asp Lys 
145                 150                 155                 160 


Leu Lys Lys Asp Lys Asp Asp Tyr Gln Ile Thr Leu Asn Ile Ile Ser 
                165                 170                 175     


Glu Asp Glu Leu Glu Arg Lys Arg Lys Ile Tyr Asp Ile Phe Lys Met 
            180                 185                 190         


Ile Asn Met Asp Leu Tyr Gln Ile Ile Lys Glu Ile Ile Glu Asn Gln 
        195                 200                 205             


Val Gln Lys Val Phe Lys Asn Arg Tyr Tyr Glu Glu His Leu Arg Glu 
    210                 215                 220                 


Lys Leu Leu Lys Asp Asp Lys Met Asp Val Ile Leu Thr Asn Phe Met 
225                 230                 235                 240 


Lys Ile Arg Glu Lys Ile Glu Ser Asn Pro Glu Ile Met Gly Phe Val 
                245                 250                 255     


Lys Phe Tyr Leu Asn Val Gly Gly Asp Lys Lys Lys Ser Glu Asn Lys 
            260                 265                 270         


Lys Met Phe Val Glu Lys Ile Leu Asn Ile Asn Val Asp Leu Thr Val 
        275                 280                 285             


Glu Asp Ile Val Asp Phe Ile Val Lys Glu Leu Lys Phe Trp Asn Ile 
    290                 295                 300                 


Thr Lys Arg Ile Glu Lys Val Lys Glu Phe Asn Asn Lys Phe Leu Glu 
305                 310                 315                 320 


Asn Lys Arg Asn Arg Thr Tyr Ile Lys Ser Tyr Val Leu Leu Asp Lys 
                325                 330                 335     


His Glu Lys Phe Lys Ile Glu Arg Glu Asn Lys Lys Asp Lys Ile Val 
            340                 345                 350         


Lys Phe Phe Val Glu Asn Ile Lys Asn Asn Ser Ile Lys Glu Lys Ile 
        355                 360                 365             


Glu Lys Ile Leu Ala Glu Phe Lys Ile Asp Glu Leu Thr Lys Lys Leu 
    370                 375                 380                 


Glu Lys Gly Asn Cys Asp Thr Glu Ile Phe Gly Ile Phe Lys Lys His 
385                 390                 395                 400 


Tyr Lys Val Asn Phe Asp Ser Lys Lys Phe Glu Asn Lys Ser Asp Glu 
                405                 410                 415     


Glu Lys Glu Leu Tyr Lys Ile Ile Tyr Arg Tyr Leu Lys Gly Arg Ile 
            420                 425                 430         


Glu Lys Ile Leu Ile Asn Glu Glu Lys Val Arg Leu Lys Lys Met Glu 
        435                 440                 445             


Lys Ile Glu Ile Glu Lys Ile Leu Asn Glu Ser Ile Leu Ser Glu Lys 
    450                 455                 460                 


Ile Leu Lys Arg Val Lys Gln Tyr Thr Leu Glu His Ile Met Tyr Leu 
465                 470                 475                 480 


Gly Lys Leu Val His Asn Lys Ile Asn Met Ala Thr Val Asn Thr Asn 
                485                 490                 495     


Asp Phe Phe Arg Leu His Ala Lys Glu Glu Leu Asp Leu Glu Leu Ile 
            500                 505                 510         


Thr Phe Leu Ala Ser Thr Asn Met Glu Leu Asn Lys Ile Phe Asn Gly 
        515                 520                 525             


Lys Glu Lys Val Thr Asp Phe Phe Gly Phe Asn Leu Asn Gly Gln Lys 
    530                 535                 540                 


Ile Thr Leu Lys Glu Lys Val Pro Ser Phe Lys Leu Asn Ile Leu Lys 
545                 550                 555                 560 


Lys Leu Asn Phe Ile Asn Asn Glu Asn Asn Ile Asp Glu Lys Leu Ser 
                565                 570                 575     


His Phe Tyr Ser Phe Gln Lys Lys Gly Tyr Leu Leu Arg Asn Lys Ile 
            580                 585                 590         


Leu His Asn Ser Tyr Gly Asn Ile Gln Glu Thr Ile Asn Leu Lys Gly 
        595                 600                 605             


Glu Tyr Glu Asn Val Glu Asn Leu Ile Lys Glu Leu Lys Val Ser Asn 
    610                 615                 620                 


Glu Glu Ile Ser Lys Ser Leu Asn Leu Asp Ile Ile Phe Glu Gly Lys 
625                 630                 635                 640 


Val Asp Ile Ile Asn Lys Ile Asn Ser Leu Glu Ile Gly Glu Tyr Lys 
                645                 650                 655     


Asp Lys Lys Tyr Leu Pro Ser Phe Ser Lys Ile Val Pro Glu Ile Met 
            660                 665                 670         


Arg Lys Phe Arg Glu Ile Asn Lys Asp Lys Ser Phe Asp Ile Glu Ser 
        675                 680                 685             


Glu Lys Ile Ile Leu Asn Ala Val Gln Tyr Val Asn Lys Ile Leu Tyr 
    690                 695                 700                 


Glu Lys Ile Thr Ser Asn Glu Glu Asn Glu Phe Ile Lys Thr Leu Pro 
705                 710                 715                 720 


Asp Lys Leu Val Lys Lys Asn Asn Asn Lys Glu Asn Asn Asn Ser Leu 
                725                 730                 735     


Ser Ile Glu Glu Tyr Tyr Lys Asn Ala Gln Ile Ser Ser Ser Lys Gly 
            740                 745                 750         


Asp Lys Lys Ala Ile Lys Lys Tyr Gln Asn Lys Val Thr Asn Ala Tyr 
        755                 760                 765             


Ile Glu Tyr Leu Glu Asn Thr Phe Ala Glu Val Ile Asp Phe Ser Asn 
    770                 775                 780                 


Phe Asn Leu Asn Phe Asp Glu Ile Lys Thr Lys Ile Glu Glu Arg Lys 
785                 790                 795                 800 


Tyr Ser Lys Ser Lys Ile Thr Val Asp Ser Ile Ser Thr Asn Ile Asn 
                805                 810                 815     


Ile Thr Asn Asp Ile Glu Tyr Ile Ile Ser Ile Phe Ala Leu Leu Asn 
            820                 825                 830         


Ser Asn Thr Tyr Ile Asn Lys Ile Arg Asn Arg Phe Phe Ala Thr Ser 
        835                 840                 845             


Val Trp Leu Asp Lys Gln Asn Ser Thr Lys Glu Tyr Asp Tyr Glu Asn 
    850                 855                 860                 


Ile Ile Asp Ile Leu Asp Lys Ile Leu Ser Ile Asn Leu Leu Arg Glu 
865                 870                 875                 880 


Asn Asn Ile Ala Asp Ile Leu Asp Leu Lys Asn Thr Ile Ile Glu Ala 
                885                 890                 895     


Lys Ile Val Glu Asn Asn Glu Glu Cys Ile Lys Asn Tyr Ile Phe Glu 
            900                 905                 910         


Asn Asn Glu Glu Glu Leu Lys Lys Arg Leu Phe Cys Glu Glu Leu Val 
        915                 920                 925             


Asn Lys Glu Asp Val Leu Lys Ile Phe Glu Asp Lys Asn Phe Lys Phe 
    930                 935                 940                 


Lys Asn Phe Ile Lys Lys Thr Gly Asn Glu Asn Phe Thr Ile Asn Phe 
945                 950                 955                 960 


Asp Ile Leu Phe Asn Leu Glu Cys Asn Ser Glu Leu Asn Val Lys Lys 
                965                 970                 975     


Val Met Gly Gln Asn Ser Gln Arg Leu Asn Leu Phe Ile Lys Asn Thr 
            980                 985                 990         


Ile Asp Glu Tyr Lys Ser Lys Ile  Lys Thr Ser Phe Ser  Ser Glu Phe 
        995                 1000                 1005             


Leu Glu  Lys Tyr Lys Lys Glu  Ile Asp Asn Leu Val  Glu Asp Thr 
    1010                 1015                 1020             


Glu Ser  Glu Asn Lys Asn Lys  Phe Glu Lys Ile Tyr  Tyr Pro Lys 
    1025                 1030                 1035             


Glu His  Lys Asn Glu Leu Tyr  Ile Tyr Lys Lys Asn  Leu Phe Leu 
    1040                 1045                 1050             


Asn Ile  Gly Asn Pro Asn Phe  Asp Lys Ile Tyr Glu  Leu Ile Ser 
    1055                 1060                 1065             


Lys Asp  Ile Lys Asn Ala Asn  Thr Glu Ile Leu Phe  Asp Asp Asp 
    1070                 1075                 1080             


Ile Arg  Lys Asn Lys Ile Ser  Glu Ile Asp Ala Ile  Leu Lys Asn 
    1085                 1090                 1095             


Leu Asn  Asp Lys Leu Asn Gly  Tyr Ser Asn Asp Tyr  Lys Ala Lys 
    1100                 1105                 1110             


Tyr Val  Asn Lys Leu Lys Glu  Asn Asp Asp Phe Phe  Ala Lys Asn 
    1115                 1120                 1125             


Met Lys  Asn Glu Asn Tyr Ser  Ser Phe Gly Glu Phe  Glu Lys Asp 
    1130                 1135                 1140             


Tyr Asn  Lys Val Ser Glu Tyr  Lys Lys Ile Arg Asp  Leu Val Glu 
    1145                 1150                 1155             


Phe Asn  Tyr Leu Asn Lys Ile  Glu Ser Tyr Leu Ile  Asp Ile Asn 
    1160                 1165                 1170             


Trp Lys  Leu Ala Ile Gln Met  Ala Arg Phe Glu Arg  Asp Met His 
    1175                 1180                 1185             


Tyr Ile  Val Asn Gly Leu Arg  Glu Leu Gly Ile Ile  Lys Leu Ser 
    1190                 1195                 1200             


Gly Tyr  Asn Thr Gly Ile Ser  Arg Ala Tyr Pro Lys  Arg Asn Gly 
    1205                 1210                 1215             


Ser Asp  Gly Phe Tyr Thr Thr  Thr Ala Tyr Tyr Lys  Phe Phe Asp 
    1220                 1225                 1230             


Glu Glu  Ser Tyr Lys Lys Phe  Glu Lys Ile Cys Tyr  Gly Phe Gly 
    1235                 1240                 1245             


Ile Asp  Leu Ser Glu Asn Ser  Glu Ile Asn Lys Pro  Glu Asn Glu 
    1250                 1255                 1260             


Ser Ile  Arg Asn Tyr Ile Ser  His Phe Tyr Ile Val  Arg Asn Pro 
    1265                 1270                 1275             


Phe Val  Asp Tyr Ser Ile Ala  Glu Gln Ile Asp Arg  Val Ser Asn 
    1280                 1285                 1290             


Leu Leu  Ser Tyr Ser Thr Arg  Tyr Asn Asn Ser Thr  Tyr Ala Ser 
    1295                 1300                 1305             


Val Phe  Glu Val Phe Lys Lys  Asp Val Asn Leu Asp  Tyr Asp Lys 
    1310                 1315                 1320             


Leu Lys  Thr Lys Phe Lys Leu  Phe Asp Asp Glu Lys  Asn Asp Asn 
    1325                 1330                 1335             


Ile Lys  Ile Leu Lys Ile Glu  Asn Leu Ile Glu Ser  Lys Lys Val 
    1340                 1345                 1350             


Ser Val  Leu Glu Leu Glu Ser  Tyr Asn Ser Asp Tyr  Ile Lys Asn 
    1355                 1360                 1365             


Leu Ile  Ile Glu Leu Leu Thr  Lys Ile Glu Asn Thr  Asn Asp Thr 
    1370                 1375                 1380             


Leu 
    


<210>  118
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  118

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Thr Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Val Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Lys Ile Pro Tyr Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Lys Asn Ile Glu Glu Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Thr Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Thr Thr  Asn Arg Asn Ser Lys  Glu Leu Cys 
    1130                 1135                 1140             


Lys Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Glu  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  119
<211>  1071
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  119

Met Gly Ser Gly Lys Tyr Arg Ile Thr Lys Ile Ala Arg Lys Trp Asp 
1               5                   10                  15      


Lys Asn Glu Asn Trp Glu Lys Ile Ile Leu Lys Arg Ile Val Gly Asn 
            20                  25                  30          


Lys Lys Ile Lys Tyr Val Asn Glu Asn Asn Asn Lys Asp Val Asp Ile 
        35                  40                  45              


Thr Asp Thr Tyr Tyr Asn Ile Leu Ser Lys Asn Asn Ser Lys Phe Leu 
    50                  55                  60                  


Gly Ser Glu Glu Gln Phe Leu Phe Lys Val Asn Lys Met Asp Arg Asn 
65                  70                  75                  80  


Ile Lys Asn Asp Tyr Val Ile Ile Lys Asp Tyr Asn Asp Glu Glu Phe 
                85                  90                  95      


Glu Lys Phe Asp Lys Lys Ile Phe Phe Ser Arg Lys Ile Lys Val Asn 
            100                 105                 110         


Asn Glu Asp Arg Glu Lys Ile Cys Arg Asn Phe Tyr Glu Asp Glu Arg 
        115                 120                 125             


Glu Ile Met Lys Lys Arg Leu Glu Glu Ala Lys Asn Phe Asn Asn Ile 
    130                 135                 140                 


Ile Phe Asn Ile Cys Asn Lys Ile Phe Lys Leu Glu Tyr Leu Asp Tyr 
145                 150                 155                 160 


Thr Asp Glu Lys Val Tyr Lys Ile Phe Gln Asn Glu Ile Lys Val Lys 
                165                 170                 175     


Asp Val Lys Asn Leu Lys Glu Ala Phe Lys Gln Gln Glu Lys Gly Leu 
            180                 185                 190         


Glu Thr Asp Lys Leu Leu Ala Ile Ser Phe Asn Lys Asn Arg Asn Asn 
        195                 200                 205             


Ile Leu Leu Glu Phe Val Gln Gln Ile Thr Lys Gln Glu Phe Lys Asn 
    210                 215                 220                 


Gln Lys Glu Leu Glu Asn Trp Phe Ser His Ser Gly Glu Lys Tyr Cys 
225                 230                 235                 240 


Lys Lys Ile Phe Lys Ile Tyr Ser Asn Met Ser Gln Lys Glu Lys Tyr 
                245                 250                 255     


Ser Lys Leu Leu Gly His Lys Asn Lys Ser Ile Ala Ser Ile Ser Glu 
            260                 265                 270         


Lys Lys Glu Thr Leu Gln Arg Arg Leu Lys Leu Gly Asn Tyr Ser Asn 
        275                 280                 285             


Tyr Asp Leu Arg Lys Tyr Tyr Gln Lys Asp Tyr Lys Glu Glu Ala Ile 
    290                 295                 300                 


Arg Glu Leu Lys Asp Lys Asn Lys Glu Glu Leu Glu Arg Glu Ile Glu 
305                 310                 315                 320 


Lys Leu Ile Lys Glu Asn Tyr Lys Ile Asp Glu Leu Cys Asp Glu Ile 
                325                 330                 335     


Ser Asn Leu Glu Phe Ser Phe Val Asp Ser Lys Lys Glu Asn Lys Asp 
            340                 345                 350         


Lys Met Ser Glu Ile Ile Val Lys Ile Lys Glu His Tyr Lys Asn Asn 
        355                 360                 365             


Val Asn Ile Glu Glu Arg Leu Glu Asn Lys Glu Lys Tyr Ile Leu Ser 
    370                 375                 380                 


Met Ile His Asn Tyr Val Lys Gly Arg Tyr Arg Lys Cys Leu Glu Leu 
385                 390                 395                 400 


Gln Gln Lys Glu Asn Val Asp Phe Glu Asn Leu Glu Lys Arg Ile Lys 
                405                 410                 415     


Glu Ile Phe Asp Ser Asn Glu Val Thr Lys Lys Leu Lys Lys Ser Ile 
            420                 425                 430         


Ser Thr Ala Val Ser Lys Val Gly Tyr Thr Leu Asn Thr Leu Leu Glu 
        435                 440                 445             


Val Asn Pro Glu Lys Asp Ile Leu Glu Lys Tyr Glu Glu Val Glu Lys 
    450                 455                 460                 


Leu Cys Thr Asn Asn Ser Ile Lys Asn Leu Cys Thr Val Tyr Ser Glu 
465                 470                 475                 480 


Ile Asn Asn Asn Glu Lys Leu Leu Lys Gly Met Ile Tyr Phe Ile Gln 
                485                 490                 495     


Gly Leu Arg Gln Gln Val Leu His Pro Lys Ile Leu Trp Glu Lys Asn 
            500                 505                 510         


Val His Lys Ala Glu Lys Val Lys Glu Lys Glu Lys Ile Val Ile Arg 
        515                 520                 525             


Phe Gln Asn Glu Gly Lys Ala Tyr Asn Lys Lys Arg Ile Glu Glu Tyr 
    530                 535                 540                 


Phe Glu Asn Ile Leu Glu Lys Ile Pro Asn Tyr Phe Ile Glu Lys Tyr 
545                 550                 555                 560 


Glu Ser Asn Asn Val Phe Asn Ile Tyr Arg Asn Phe Ile Asp Glu Ile 
                565                 570                 575     


Phe Glu Ile Ile Asp Lys Phe Asp Phe Lys Glu Ser Asn Ser Ile Ser 
            580                 585                 590         


Tyr Leu Phe Pro Lys Phe His Lys Ile Tyr Lys Arg Ile Cys Lys Ser 
        595                 600                 605             


Glu Asn Ile Asn Asp Arg Gln Asn Gly Ala Arg Lys Tyr Leu Leu Gln 
    610                 615                 620                 


Thr Ile Tyr Tyr Tyr Tyr Phe Gln Tyr Glu Ile Glu Asn Asn Lys Asn 
625                 630                 635                 640 


Asp Ile Phe Lys Tyr Leu Asn Leu Tyr Lys Ser Lys Ile Lys Ala Lys 
                645                 650                 655     


Lys Ile Ser Tyr Ser His Ile Ile Asp Asn Lys Asp Val Asn Asn Lys 
            660                 665                 670         


Asn Ile Glu Ile Leu Tyr Arg Asn Ile Gln Arg Glu Gly Met Leu Asn 
        675                 680                 685             


Asn Arg Leu Leu Gln Met Asn Asn Glu Trp Ile Glu Phe Met Val Val 
    690                 695                 700                 


Gln Phe Ser Glu Phe Leu Thr Asn Lys Lys Leu Asn Trp Ile Leu Asp 
705                 710                 715                 720 


Asp Leu Ser Glu Tyr Lys Lys Lys Glu Lys Leu Asp Glu Asn Asp Lys 
                725                 730                 735     


Asn Lys Leu Leu Lys Thr Leu Lys Gln Lys Met Asn Lys Lys Ile Thr 
            740                 745                 750         


Tyr Ser Asn Asp Ser Tyr Val Phe Ile Ser Leu Ala Gln Phe Leu Asp 
        755                 760                 765             


Leu Lys Glu Ile Ser Asn Leu Ile His Asp Ile Lys Lys Phe Ile Gln 
    770                 775                 780                 


Phe Arg Glu Lys Asn Val Ser Lys Tyr Lys Pro Glu Lys Asn Lys Leu 
785                 790                 795                 800 


Tyr Ile Lys Glu Leu Arg Lys Val Leu Tyr Ile Leu Lys Val Met Leu 
                805                 810                 815     


Glu His Lys Glu Arg Val Ile Gln Lys His Tyr Leu Glu Ser Tyr Asp 
            820                 825                 830         


Glu Asn Ile Ser Ile Ile Tyr Gly Lys Asp Ile Glu Arg Lys Asp Ile 
        835                 840                 845             


Lys Asp Ile Lys Ile Lys Ile Lys Asn Glu Asn Gln Glu Val Ile Asn 
    850                 855                 860                 


Gln Pro Leu Tyr Lys Ser Gly Asn Asp Glu Asn Ser Ser Trp Ile Val 
865                 870                 875                 880 


Leu Tyr Gly Ile Glu Gln Ala Lys Arg Asn Gly Thr Phe Lys Phe Phe 
                885                 890                 895     


Glu Gly Phe Phe Asn Leu Asn Asp Asp Ile Lys Leu Cys Lys Glu Asn 
            900                 905                 910         


Ile Glu Lys Tyr Glu Glu Leu Tyr Asn Glu Lys Glu Glu Asn Gln Arg 
        915                 920                 925             


Lys Val Asp Glu Tyr Ile Ser Ser Glu Glu Asn Asn Asn Ile Asp Glu 
    930                 935                 940                 


Ile Glu Glu Ile Asn Asn Asn Lys Gln Leu Phe Tyr Tyr Tyr Lys Asn 
945                 950                 955                 960 


Met Ile Tyr Gly Asp Gly Leu Lys Lys Gly Tyr Asp Phe Ile Asn Asp 
                965                 970                 975     


Ile Tyr Ser His Tyr Leu Ser Trp Ala Tyr Arg Val Glu Arg Asp Cys 
            980                 985                 990         


Lys Ile Tyr Lys Ile Lys Glu Tyr  Glu Asn Lys Lys Asn  Phe Asn Glu 
        995                 1000                 1005             


Tyr Lys  Phe Lys Glu Tyr Lys  Ser Ile Lys Asn Phe  Arg Asn Glu 
    1010                 1015                 1020             


Ile Ala  His Phe Asn Tyr Phe  Gln Lys Thr Asn Lys  Ser Leu Leu 
    1025                 1030                 1035             


Glu Leu  Leu Asn Asp Phe Tyr  Asp Ile Phe Asp Tyr  Asn Leu Lys 
    1040                 1045                 1050             


Tyr Gln  Arg Asp Val Gln Lys  Val Ile Asn Asn Ile  Lys Gln Cys 
    1055                 1060                 1065             


Val His  Ile 
    1070     


<210>  120
<211>  1177
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  120

Met Lys Ile Thr Lys Val Asp Gly Leu Ser His Tyr Lys Lys Gln Asp 
1               5                   10                  15      


Lys Gly Ile Leu Lys Lys Lys Trp Arg Asp Leu Asp Glu Arg Lys Gln 
            20                  25                  30          


Arg Glu Lys Ile Glu Glu Arg Tyr Asn Lys Gln Ile Glu Ser Lys Ile 
        35                  40                  45              


Tyr Lys Glu Phe Phe Arg Leu Lys Asn Lys Lys Arg Ile Glu Lys Glu 
    50                  55                  60                  


Glu Asp Gln Asn Ile Lys Ser Leu Tyr Phe Phe Ile Lys Glu Met Tyr 
65                  70                  75                  80  


Leu Asn Glu Glu Asn Glu Glu Trp Glu Leu Lys Asn Ile Asn Leu Glu 
                85                  90                  95      


Ile Leu Asp Asp Lys Glu Arg Val Ile Lys Gly Tyr Lys Phe Lys Glu 
            100                 105                 110         


Asp Val Tyr Phe Phe Lys Glu Gly Asp Lys Lys Tyr Tyr Leu Arg Thr 
        115                 120                 125             


Leu Leu Asn Asn Leu Ile Glu Lys Ile Gln Asn Glu Asn Arg Asp Lys 
    130                 135                 140                 


Val Arg Lys Asn Lys Glu Phe Ser Asp Leu Lys Glu Ile Phe Lys Lys 
145                 150                 155                 160 


Tyr Lys Asp Arg Lys Ile Lys Leu Leu Leu Glu Ser Ile Asn Asn Asn 
                165                 170                 175     


Lys Ile Asn Leu Glu Tyr Lys Lys Glu Asn Val Asn Glu Glu Ile Tyr 
            180                 185                 190         


Gly Ile Asn Pro Thr Asn Asp Arg Glu Met Thr Phe His Glu Leu Leu 
        195                 200                 205             


Lys Glu Ile Ile Glu Lys Lys Asp Glu Gln Lys Ser Ile Leu Glu Glu 
    210                 215                 220                 


Lys Leu Asp Asn Phe Asp Ile Thr Asn Phe Leu Glu Asn Ile Glu Lys 
225                 230                 235                 240 


Ile Phe Asn Glu Glu Thr Glu Ile Asn Ile Ile Lys Gly Lys Val Leu 
                245                 250                 255     


Asn Glu Leu Arg Glu Tyr Ile Arg Glu Lys Glu Glu Asn Asn Ser Asp 
            260                 265                 270         


Tyr Lys Leu Lys Gln Ile Tyr Asn Leu Glu Leu Lys Lys Tyr Ile Glu 
        275                 280                 285             


Asn Asn Phe Ser Tyr Lys Lys Gln Lys Ser Lys Ser Lys Asn Gly Lys 
    290                 295                 300                 


Asn Asp Tyr Leu Tyr Leu Asn Phe Leu Lys Lys Ile Met Phe Ile Glu 
305                 310                 315                 320 


Glu Val Asp Glu Lys Lys Gly Ile Asn Lys Glu Lys Phe Lys Asn Lys 
                325                 330                 335     


Ile Asn Ser Asn Phe Lys Asn Leu Phe Val Gln His Ile Leu Asp Tyr 
            340                 345                 350         


Gly Lys Leu Leu Tyr Tyr Lys Glu Asn Asp Glu Tyr Ile Lys Asn Thr 
        355                 360                 365             


Gly Gln Leu Glu Thr Lys Asp Leu Glu Tyr Ile Lys Thr Lys Glu Thr 
    370                 375                 380                 


Leu Ile Arg Lys Met Ala Val Leu Val Ser Phe Ala Ala Asn Ser Tyr 
385                 390                 395                 400 


Tyr Asn Leu Phe Gly Arg Thr Glu Asn Asn Ile Leu Thr Gln Glu Ile 
                405                 410                 415     


Ser Asp Asp Leu Leu Leu Gly Lys Ile Glu Asn Glu Ile Tyr Ile Lys 
            420                 425                 430         


Gly Glu Lys Asn Arg Arg Tyr Val Phe Lys Glu Lys Met Leu Asn Tyr 
        435                 440                 445             


Phe Phe Asn Pro Glu Ile Phe Gly Asp Asn Lys Ile Val Glu Val Leu 
    450                 455                 460                 


Ser Ala Ile Ser Ser Ser Ile Tyr Asn Ile Arg Asn Gly Val Asn His 
465                 470                 475                 480 


Phe Asp Lys Ile Asn Leu Gly Gln Tyr Asn Asn Leu Asp Leu Ser Glu 
                485                 490                 495     


Ile Lys Lys Tyr Phe Ile Glu Lys Arg Asp Lys Ile Lys Glu Lys Val 
            500                 505                 510         


Lys Glu Lys Phe Ser Ser Asn Asn Leu Gln Tyr Tyr Tyr Ala Lys Lys 
        515                 520                 525             


Glu Ile Glu Asn Tyr Phe Lys Ala Tyr Glu Phe Glu Ile Leu Lys Glu 
    530                 535                 540                 


Lys Ile Pro Phe Ala Pro Asn Phe Lys Arg Ile Ile Lys Lys Gly Glu 
545                 550                 555                 560 


Asp Leu Phe Asn Asn Lys Lys Asn Lys Lys Tyr Glu Tyr Phe Lys Asn 
                565                 570                 575     


Phe Asp Lys Asn Ile Ala Glu Glu Lys Lys Glu Phe Leu Lys Thr Arg 
            580                 585                 590         


Asn Phe Leu Leu Lys Glu Leu Tyr Tyr Asn Asn Phe Tyr Lys Glu Phe 
        595                 600                 605             


Leu Ser Lys Lys Glu Glu Phe Lys Lys Val Val Ile Glu Val Lys Glu 
    610                 615                 620                 


Glu Lys Lys Asn Arg Gly Asn Ile Asn Asn Lys Lys Ser Gly Val Ser 
625                 630                 635                 640 


Phe Gln Ser Ile Asp Asp Tyr Asp Thr Lys Ile Asn Ile Ser Asp Tyr 
                645                 650                 655     


Ile Ala Ser Ile His Lys Lys Glu Met Glu Arg Val Glu Lys Tyr Asn 
            660                 665                 670         


Glu Glu Lys Gln Lys Asp Thr Ala Lys Tyr Ile Arg Asp Phe Val Glu 
        675                 680                 685             


Glu Ile Phe Leu Thr Gly Phe Ile Asn Tyr Leu Glu Lys Asp Lys Arg 
    690                 695                 700                 


Leu His Phe Leu Lys Glu Glu Phe Ser Ile Leu Cys Asn Asn Asn Asn 
705                 710                 715                 720 


Asn Val Val Asp Phe Asn Ile Asn Ile Asn Glu Glu Lys Ile Lys Glu 
                725                 730                 735     


Phe Leu Lys Glu Asn Asp Ser Lys Thr Leu Asn Leu Tyr Leu Phe Phe 
            740                 745                 750         


Asn Met Ile Asp Ser Lys Arg Ile Ser Glu Phe Arg Asn Glu Leu Ile 
        755                 760                 765             


Lys Tyr Lys Gln Phe Thr Lys Arg Arg Leu Asp Glu Lys Lys Glu Phe 
    770                 775                 780                 


Leu Gly Ile Glu Ile Glu Leu Tyr Glu Thr Leu Ile Glu Phe Val Ile 
785                 790                 795                 800 


Leu Thr Arg Glu Lys Leu Asp Thr Lys Lys Ser Glu Glu Ile Asp Ala 
                805                 810                 815     


Trp Leu Val Asp Lys Leu Tyr Val Lys Asp Asn Asn Glu Tyr Lys Glu 
            820                 825                 830         


Tyr Glu Glu Ile Leu Lys Leu Phe Val Asp Glu Lys Ile Leu Ser Ser 
        835                 840                 845             


Lys Glu Ala Pro Tyr Tyr Ala Thr Asp Asn Lys Thr Pro Ile Leu Leu 
    850                 855                 860                 


Ser Asn Phe Glu Lys Thr Arg Lys Tyr Gly Thr Gln Ser Phe Leu Ser 
865                 870                 875                 880 


Glu Ile Gln Ser Asn Tyr Lys Tyr Ser Lys Val Glu Lys Glu Asn Ile 
                885                 890                 895     


Glu Asp Tyr Asn Lys Lys Glu Glu Ile Glu Gln Lys Lys Lys Ser Asn 
            900                 905                 910         


Ile Glu Lys Leu Gln Asp Leu Lys Val Glu Leu His Lys Lys Trp Glu 
        915                 920                 925             


Gln Asn Lys Ile Thr Glu Arg Glu Ile Lys Lys Tyr Asn Asp Thr Ile 
    930                 935                 940                 


Lys Glu Ile Arg Glu Tyr Asn Tyr Leu Lys Asn Lys Glu Glu Leu Gln 
945                 950                 955                 960 


Asn Val Tyr Leu Leu His Glu Met Leu Ser Asp Leu Leu Ala Arg Asn 
                965                 970                 975     


Val Ala Phe Phe Asn Lys Trp Glu Arg Asp Phe Lys Phe Ile Val Ile 
            980                 985                 990         


Ala Ile Lys Gln Phe Leu Arg Glu  Asn Asp Lys Glu Lys  Val Asn Glu 
        995                 1000                 1005             


Phe Leu  Asn Pro His Lys Ser  Asp Gly Ser Arg Asp  Asn Phe Ser 
    1010                 1015                 1020             


Val Thr  Asn Tyr Arg Ser Lys  Met Lys Ser Ile Ile  Asn Asn Ile 
    1025                 1030                 1035             


His Glu  Asn Phe Met Ser Leu  Leu Phe Leu Asn Asn  Asn Leu Ala 
    1040                 1045                 1050             


Thr Gly  Gly Ile Gln Met Gly  Arg Asn Asn Asn Phe  Thr Trp Gly 
    1055                 1060                 1065             


Asn Leu  Arg Asn Tyr Ile Ala  His Phe Glu Tyr Leu  His Lys Glu 
    1070                 1075                 1080             


Lys Asp  Thr Ile Ser Phe Leu  Asn Gln Ala Asn Leu  Leu Ile Lys 
    1085                 1090                 1095             


Leu Phe  Ser Tyr Asp Lys Lys  Val Gln Asn His Ile  Ile Lys Ser 
    1100                 1105                 1110             


Met Lys  Thr Leu Leu Glu Lys  Tyr Asn Ile Glu Ile  Gly Phe Glu 
    1115                 1120                 1125             


Ile Ser  Asn Asp Ser Glu Glu  Ile Phe Glu Tyr Lys  Ile Lys Tyr 
    1130                 1135                 1140             


Ile Asn  Ser Lys Lys Gly Lys  Met Leu Gly Lys Asn  Asn Glu Phe 
    1145                 1150                 1155             


Glu Ile  Leu Glu Asn Glu Phe  Val Arg Asn Val Lys  Ala Leu Leu 
    1160                 1165                 1170             


Glu Tyr  Ser Lys 
    1175         


<210>  121
<211>  1149
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  121

Met Gly Ala Gly Lys Tyr Arg Ile Thr Lys Ile Pro Arg Asn Trp Lys 
1               5                   10                  15      


Glu Asn Glu Lys Lys Val Ile Leu Lys Arg Val Val Asn Asn Gly Glu 
            20                  25                  30          


Val Lys Tyr Ile Asn Glu Asn Asp Asn Val Asp Val Asp Ile Thr Glu 
        35                  40                  45              


Thr Tyr Tyr Gly Ile Leu Ser Asn Asn Lys Ala Lys Phe Leu Gly Ser 
    50                  55                  60                  


Asn Glu Gln Phe Ile Phe Lys Val Asn Lys Met Lys Arg Asn Ile Glu 
65                  70                  75                  80  


Asn Gly Cys Val Ile Ile Lys Asn Tyr Thr Glu Glu Glu Tyr Glu Lys 
                85                  90                  95      


Phe Asp Lys Lys Ile Phe Ser Lys Arg Arg Ile Lys Val Thr Asn Lys 
            100                 105                 110         


Asn Ile Glu Lys Ile Cys Arg Asn Phe Tyr Glu Asp Glu Glu Glu Ile 
        115                 120                 125             


Met Lys Lys Arg Phe Glu Glu Ala Lys Asn Phe Asn Asn Ile Ile Phe 
    130                 135                 140                 


Lys Ile Cys Ser Glu Ile Phe Glu Leu Glu Tyr Ile Asn Tyr Thr Asp 
145                 150                 155                 160 


Glu Lys Leu Tyr Lys Ile Phe Gln Asn Lys Ile Lys Val Lys Asp Val 
                165                 170                 175     


Lys Asn Leu Lys Glu Ala Phe Lys Gln Gln Glu Lys Gly Leu Glu Thr 
            180                 185                 190         


Asp Lys Leu Leu Ala Ile Ser Phe Asn Lys Lys Arg Asn Asn Ala Leu 
        195                 200                 205             


Leu Glu Phe Ile Gln Gln Ile Val Lys Gln Lys Phe Glu Asn Glu Lys 
    210                 215                 220                 


Glu Leu Glu Asn Trp Phe Ser His Ser Gly Glu Lys Tyr Cys Lys Glu 
225                 230                 235                 240 


Ile Phe Lys Ile Tyr Ser Asn Met Ser Gln Lys Glu Lys Tyr Ser Lys 
                245                 250                 255     


Leu Leu Gly His Arg Asn Lys Ser Phe Ala Ser Ile Ser Glu Lys Lys 
            260                 265                 270         


Glu Thr Leu Gln Arg Arg Leu Lys Leu Gly Asn Tyr Ser Asn Tyr Asn 
        275                 280                 285             


Leu Arg Lys Tyr Tyr Gln Lys Asp Tyr Lys Glu Glu Ala Ile Lys Glu 
    290                 295                 300                 


Leu Lys Asp Lys Ser Lys Glu Lys Leu Glu Lys Glu Ile Glu Glu Ile 
305                 310                 315                 320 


Ile Lys Glu Asn Tyr Lys Ile Asp Lys Leu Cys Glu Glu Ile Ser Asn 
                325                 330                 335     


Leu Glu Phe Ser Phe Ala Glu Ser Lys Lys Glu Asn Lys Asp Lys Met 
            340                 345                 350         


Ser Glu Ile Ile Val Lys Ile Lys Glu His Tyr Lys Asn Asn Val Asn 
        355                 360                 365             


Val Glu Glu Glu Leu Glu Asn Lys Glu Lys Tyr Ile Leu Ser Met Ile 
    370                 375                 380                 


His Asn Tyr Ile Lys Gly Arg Tyr Arg Lys Cys Leu Glu Leu Gln Gln 
385                 390                 395                 400 


Lys Glu Asn Val Asp Phe Glu Asn Leu Glu Lys Arg Ile Lys Glu Ile 
                405                 410                 415     


Phe Asp Ser Asn Glu Val Thr Lys Lys Leu Lys Lys Leu Ile Leu Asn 
            420                 425                 430         


Lys Val Asn Asn Tyr Lys Ile Phe Glu Thr Lys Phe Gln Asn Pro Asn 
        435                 440                 445             


Ile Glu Ser Ser Asp Asp Leu Glu Ile Leu Lys Ala Glu Glu Thr Phe 
    450                 455                 460                 


Leu Asn Lys Leu Ser Thr Ala Val Ser Lys Val Gly Tyr Thr Leu Asn 
465                 470                 475                 480 


Thr Leu Leu Glu Val Ser Pro Glu Lys Asp Ile Leu Glu Lys Tyr Glu 
                485                 490                 495     


Glu Val Glu Lys Leu Cys Thr Ser Asn Ser Ile Lys Asn Leu Cys Thr 
            500                 505                 510         


Val Tyr Ser Glu Ile Asn Asn Asn Glu Lys Leu Leu Lys Gly Met Ile 
        515                 520                 525             


Tyr Phe Ile Gln Gly Leu Arg Gln Gln Val Leu His Pro Lys Ile Leu 
    530                 535                 540                 


Trp Glu Lys Asn Val His Lys Ala Glu Lys Val Lys Glu Lys Glu Lys 
545                 550                 555                 560 


Ile Val Ile Arg Phe Gln Asn Glu Gly Lys Ala Tyr Asn Lys Lys Arg 
                565                 570                 575     


Ile Glu Glu Tyr Phe Glu Asn Ile Leu Glu Lys Ile Pro Asp Tyr Phe 
            580                 585                 590         


Ile Glu Lys Tyr Glu Ser Asn Asn Val Phe Asn Ile Tyr Arg Asn Phe 
        595                 600                 605             


Ile Asp Glu Ile Phe Glu Ile Ile Asp Lys Phe Asp Phe Lys Glu Ser 
    610                 615                 620                 


Asn Ser Ile Ser Tyr Leu Phe Pro Lys Phe His Lys Ile Tyr Lys Arg 
625                 630                 635                 640 


Ile Cys Lys Ser Glu Asn Ile Asn Asp Arg Gln Asn Gly Ala Arg Lys 
                645                 650                 655     


Tyr Leu Leu Gln Thr Ile Tyr Tyr Tyr Tyr Phe Gln Tyr Glu Ile Glu 
            660                 665                 670         


Asn Asn Lys Asn Asp Ile Phe Lys Tyr Leu Asn Leu Tyr Lys Ser Lys 
        675                 680                 685             


Ile Lys Ala Lys Lys Ile Ser Tyr Ser His Ile Ile Asp Asn Lys Asp 
    690                 695                 700                 


Val Asn Asn Lys Asn Ile Glu Ile Leu Tyr Arg Asn Ile Gln Arg Glu 
705                 710                 715                 720 


Gly Met Leu Asn Asn Arg Leu Leu Gln Met Asn Asn Glu Trp Ile Glu 
                725                 730                 735     


Phe Ile Met Ile Gln Phe Ile Glu Phe Ile Ser Thr Lys Lys Leu Asn 
            740                 745                 750         


Trp Ile Leu Asp Asp Leu Ser Glu Tyr Arg Lys Lys Glu Lys Leu Asp 
        755                 760                 765             


Glu Lys Asn Lys Asn Lys Leu Leu Glu Asn Leu Lys Gln Lys Met Asn 
    770                 775                 780                 


Lys Asn Ile Thr Tyr Ser Asn Asp Ser Tyr Val Phe Ile Ser Leu Ala 
785                 790                 795                 800 


Gln Phe Leu Asp Leu Lys Glu Ile Ser Asn Leu Ile His Asp Ile Lys 
                805                 810                 815     


Lys Phe Val Gln Phe Arg Glu Lys Asn Ile Ser Lys Tyr Lys Pro Glu 
            820                 825                 830         


Lys Asn Lys Val Tyr Ile Glu Glu Leu Arg Lys Ile Ser Tyr Ile Leu 
        835                 840                 845             


Lys Val Met Leu Glu His Lys Glu Arg Val Ile Gln Lys His Tyr Leu 
    850                 855                 860                 


Glu Ser Tyr Asp Glu Gly Ile Ser Ile Met Tyr Gly Lys Asp Ile Glu 
865                 870                 875                 880 


Lys Lys Gly Ile Lys Asp Ile Lys Ile Lys Ile Lys Asn Glu Asn Gln 
                885                 890                 895     


Glu Val Ile Asn Gln Pro Leu Tyr Lys Ser Gly Asn Asp Glu Asn Ser 
            900                 905                 910         


Ser Trp Ile Val Leu Tyr Gly Ile Glu Gln Ala Lys Arg Asn Gly Thr 
        915                 920                 925             


Phe Lys Phe Phe Lys Glu Phe Phe Asn Thr Asn Glu Asp Ile Lys Leu 
    930                 935                 940                 


Cys Lys Glu Asp Ile Gln Lys Tyr Glu His Leu Tyr Asn Glu Lys Glu 
945                 950                 955                 960 


Glu Asn Gln Arg Lys Val Asp Glu Tyr Ile Ser Ser Glu Glu Asn Asn 
                965                 970                 975     


Asn Ile Glu Glu Ile Lys Glu Ile Asn Asn Asn Lys Lys Gln Leu Phe 
            980                 985                 990         


Tyr Tyr Tyr Lys Asn Met Ile Asn  Gly Asp Gly Leu Lys  Lys Gly Tyr 
        995                 1000                 1005             


Asp Phe  Ile Asn Asp Ile Tyr  Ser His Cys Leu Ser  Trp Ala Tyr 
    1010                 1015                 1020             


Arg Ile  Glu Arg Asp Cys Ser  Ile Tyr Lys Val Glu  Ala Tyr Asn 
    1025                 1030                 1035             


Gly Lys  Ile Lys Asn Phe Arg  Asn Glu Ile Ala His  Phe Asn Tyr 
    1040                 1045                 1050             


Phe Gln  Lys Thr Asp Lys Ser  Leu Leu Asp Leu Leu  Asn Asp Phe 
    1055                 1060                 1065             


Tyr Asn  Ile Phe Asp Tyr Asn  Leu Lys Tyr Gln Arg  Asp Val Gln 
    1070                 1075                 1080             


Lys Val  Ile Asn Asn Ile Phe  Glu Lys Tyr Gln Val  Val Arg Glu 
    1085                 1090                 1095             


Asp Gly  Gly Pro Val Ile Phe  Tyr Cys Lys Val Asp  Lys Lys Leu 
    1100                 1105                 1110             


Lys Leu  Ser Glu Asn Leu Val  Pro Lys Lys His Ser  Lys Tyr Pro 
    1115                 1120                 1125             


Glu Ile  Glu Leu Val His Lys  Lys Tyr Val Ile Phe  Phe Lys Lys 
    1130                 1135                 1140             


Leu Phe  Glu His Lys Lys 
    1145                 


<210>  122
<211>  1187
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  122

Met Lys Val Thr Lys Ile Asp Gly Leu Ser His Lys Lys Phe Glu Asn 
1               5                   10                  15      


Glu Gly Lys Leu Ile Lys Ile Lys Asp Ala Ser Gln Lys Asn Glu Thr 
            20                  25                  30          


Lys Glu Arg Leu Glu Lys Leu Lys Glu Ile Lys Leu Gly Asn Tyr Ile 
        35                  40                  45              


Lys Asn Pro Asp Lys Thr Lys Asp Lys Asp Asn Lys Lys Arg Arg Lys 
    50                  55                  60                  


Glu Leu Lys Glu Tyr Phe Ser Glu Ile Thr Leu Arg Lys Glu Asn Gly 
65                  70                  75                  80  


Lys Tyr Val Leu Leu Lys Ser Lys Lys Leu Lys Lys Ile Asn Asn Asn 
                85                  90                  95      


Ile Lys Asp Thr Asp Ile Lys Val Lys His Lys Lys Glu Glu Val Phe 
            100                 105                 110         


Asp Val Leu Lys Glu Ile Leu Gln Leu Asn Leu Leu Ala Asn Asp Val 
        115                 120                 125             


Glu Glu Lys Ile Gln Phe Asp Ser Ile Lys Leu Lys Asn Val Phe Gly 
    130                 135                 140                 


Lys Asp Phe Val Lys Lys Glu Leu Gln Ile Lys Ser Ile Glu Glu Ser 
145                 150                 155                 160 


Leu Glu Lys Asn Lys Ala Asp Tyr Arg Lys Glu Phe Ile Glu Thr Glu 
                165                 170                 175     


Asn Asn Lys Tyr Gly Asn Val Lys Gly Glu Asn Lys Lys Asn Cys Ile 
            180                 185                 190         


Tyr Glu Tyr Tyr Lys Lys Ser Lys Thr His Glu Lys Phe Arg Lys Asn 
        195                 200                 205             


Ile Thr Glu Ala Phe Glu Lys Leu Tyr Thr Glu Glu Asn Ile Lys Glu 
    210                 215                 220                 


Leu Tyr Ser Lys Ile Glu Glu Val Leu Lys Lys Thr His Leu Lys Ser 
225                 230                 235                 240 


Ile Val Arg Glu Phe Tyr Gln Asn Glu Ile Ile Gly Glu Ser Glu Phe 
                245                 250                 255     


Ser Glu Lys Gly Glu Asp Gly Ile Ser Ile Leu Tyr Asn Gln Ile Ile 
            260                 265                 270         


Arg Ser Asn Glu Lys Lys Glu Lys Phe Val Lys Phe Leu Glu Asn Ile 
        275                 280                 285             


Glu Asn Leu Gln Leu Lys Glu Leu Thr Lys Ser Gln Ile Phe Tyr Lys 
    290                 295                 300                 


Tyr Phe Leu Glu Asn Glu Glu Leu Asp Asp Glu Asn Ile Lys Asn Val 
305                 310                 315                 320 


Phe Cys Tyr Phe Val Glu Ile Glu Val Asn Asp Leu Leu Lys Gly Asn 
                325                 330                 335     


Val Tyr Arg Val Ser Lys Ile Tyr Glu Asn Lys Ile Lys Asn Ile Phe 
            340                 345                 350         


Glu Tyr Asn Lys Leu Lys Lys Leu Val Val Asn Lys Leu Lys Asn Lys 
        355                 360                 365             


Leu Asn Asn Tyr Val Arg Asn Cys Gly Lys Tyr Asn Tyr His Met Glu 
    370                 375                 380                 


Asn Gly Asp Ile Ala Thr Ser Asp Ile Asn Met Arg Asn Arg Gln Thr 
385                 390                 395                 400 


Glu Ala Phe Leu Arg Ser Met Ile Gly Val Ser Ser Phe Gly Tyr Phe 
                405                 410                 415     


Ser Leu Arg Asn Ile Leu Gly Val Asn Asp Asp Asp Phe Tyr Glu Ile 
            420                 425                 430         


Glu Glu Asp Leu Thr Glu Asp Glu Arg Lys Asn Glu Ser Asn Val Leu 
        435                 440                 445             


Lys Lys Ala Lys Glu Asp Ile Thr Ser Lys Ser Ile Phe Glu Lys Val 
    450                 455                 460                 


Val Asp Lys Ser Phe Glu Lys Lys Gly Ile His Ser Ile Arg Glu Asn 
465                 470                 475                 480 


Val Lys Met Phe Tyr Gly Val Ser Phe Asp Lys Ala Asn Glu Asp Glu 
                485                 490                 495     


Leu Lys Gln Phe Phe Val Asn Met Leu Asn Ala Ile Thr Ser Ile Arg 
            500                 505                 510         


His Arg Val Val His Tyr Asn Met Asn Thr Asn Ser Glu Asn Ile Phe 
        515                 520                 525             


Asn Phe Ser Asp Ile Glu Val Ser Arg Leu Leu Lys Asn Ile Phe Glu 
    530                 535                 540                 


Lys Glu Thr Asp Lys Arg Glu Leu Lys Leu Lys Ile Phe Arg Gln Leu 
545                 550                 555                 560 


Asn Ser Ala Gly Val Phe Asp Tyr Trp Glu Asp Trp Lys Ile Glu Lys 
                565                 570                 575     


Tyr Leu Lys Asn Ile Glu Phe Lys Phe Val Asn Lys Asn Ile Pro Phe 
            580                 585                 590         


Val Pro Ser Phe Thr Lys Leu Tyr Asn Arg Ile Asp Asn Leu Lys Gly 
        595                 600                 605             


Ser Asn Ala Leu Asn Leu Gly Phe Ile Asn Ile Pro Lys Arg Lys Glu 
    610                 615                 620                 


Ala Arg Asp Ser Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu 
625                 630                 635                 640 


Phe Val Glu Lys Phe Val Asn Asn Asn Asp Asn Phe Glu Lys Ile Phe 
                645                 650                 655     


Arg Glu Ile Ile Glu Ile Asn Lys Asn Ala Gly Thr Asn Thr Lys Thr 
            660                 665                 670         


Lys Phe Tyr Lys Leu Glu Lys Phe Glu Thr Leu Lys Ala Asn Thr Pro 
        675                 680                 685             


Thr Glu Tyr Leu Glu Lys Leu Gln Ser Leu His Gln Ile Asn Tyr Asp 
    690                 695                 700                 


Lys Glu Lys Ile Glu Glu Asp Lys Asp Val Tyr Val Asp Phe Val Gln 
705                 710                 715                 720 


Lys Ile Phe Leu Lys Gly Phe Ile Asn Tyr Leu Gln Lys Ser Asn Ser 
                725                 730                 735     


Leu Lys Leu Leu Asn Leu Leu Asn Leu Lys Lys Asp Glu Val Ile Asn 
            740                 745                 750         


Ser Glu Lys Ser Ser Tyr Asp Glu Lys Leu Lys Gln Trp Glu Asn Asn 
        755                 760                 765             


Gly Ser Lys Leu Ser Glu Met Pro Lys Glu Ile Tyr Arg Tyr Ile Lys 
    770                 775                 780                 


Glu Ile Asn Ile Asn Lys Thr Asn Tyr Ser Asp Arg Met Ser Ile Phe 
785                 790                 795                 800 


Tyr Leu Leu Leu Lys Leu Ile Asp His Lys Glu Leu Thr Asn Leu Arg 
                805                 810                 815     


Gly Asn Leu Glu Lys Tyr Glu Ser Met Asn Lys Asn Lys Ile Tyr Ser 
            820                 825                 830         


Glu Glu Leu Asn Ile Val Asn Leu Val Ser Leu Asp Asn Asn Lys Val 
        835                 840                 845             


Arg Thr Asn Phe Ser Val Glu Ala Glu Asp Ile Gly Lys Phe Leu Lys 
    850                 855                 860                 


Thr Glu Thr Ser Ile Lys Leu Asn Asn Phe Ser Lys Met Phe Ala Asp 
865                 870                 875                 880 


Glu Gln Asn Val Ile Lys His Arg Ser Phe Tyr Asn Ile Lys Lys Tyr 
                885                 890                 895     


Gly Ile Leu Asp Leu Leu Glu Lys Ile Val Ala Lys Ala Asp Leu Lys 
            900                 905                 910         


Ile Thr Lys Glu Glu Ile Lys Lys Tyr Glu Asn Leu Gln Asn Glu Leu 
        915                 920                 925             


Lys Arg Asn Asp Phe Tyr Lys Ile Gln Glu Lys Ile His Arg Lys Tyr 
    930                 935                 940                 


Asn Gln Lys Pro Asn Leu Ile Ser Arg Thr Glu Asn Lys Lys Asp Phe 
945                 950                 955                 960 


Asn Asp Tyr Lys Lys Ala Ile Glu Asn Ile Gln Asn Tyr Thr Gln Leu 
                965                 970                 975     


Lys Asn Lys Ile Glu Phe Asn Asp Leu Asn Leu Leu Gln Ser Leu Leu 
            980                 985                 990         


Phe Arg Ile Leu His Arg Leu Ala  Gly Tyr Thr Ser Leu  Trp Glu Arg 
        995                 1000                 1005             


Asp Leu  Gln Phe Lys Leu Lys  Gly Glu Phe Pro Glu  Asp Lys Tyr 
    1010                 1015                 1020             


Ile Asp  Glu Ile Phe Asn Ser  Asp Gly Asn Asn Asn  Gln Lys Tyr 
    1025                 1030                 1035             


Lys Asn  Gly Gly Ile Ala Asp  Lys Tyr Ala Asp Phe  Leu Ile Glu 
    1040                 1045                 1050             


Lys Glu  Glu Glu Lys Ser Gly  Glu Ile Leu Lys Lys  Asn Gln Arg 
    1055                 1060                 1065             


Asn Lys  Arg Lys Lys Lys Ile  Lys Glu Asp Leu Glu  Ile Arg Asn 
    1070                 1075                 1080             


Tyr Ile  Ala His Phe Asn Tyr  Phe Pro Asp Ala Thr  Lys Ser Ile 
    1085                 1090                 1095             


Leu Glu  Leu Leu Glu Glu Leu  Arg Glu Leu Leu Lys  Tyr Asp Arg 
    1100                 1105                 1110             


Lys Leu  Lys Asn Ala Val Met  Lys Ser Val Lys Asp  Ile Phe Lys 
    1115                 1120                 1125             


Glu Tyr  Gly Phe Ile Val Glu  Phe Gly Ile Ser His  Glu Ser Asn 
    1130                 1135                 1140             


Ser Lys  Lys Ile Lys Val Cys  Asp Val Lys Ser Glu  Glu Ile Lys 
    1145                 1150                 1155             


His Leu  Lys Asn Asn Gly Leu  Val Thr Thr Arg Asn  Ser Glu Asp 
    1160                 1165                 1170             


Leu Cys  Glu Leu Val Lys Val  Met Leu Glu Tyr Lys  Lys Ser 
    1175                 1180                 1185         


<210>  123
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  123

Met Lys Ile Thr Lys Ile Asp Gly Ile Ser His Lys Lys Tyr Ile Lys 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Lys Thr Asp Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Thr Ile Arg Leu Asp Thr Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Glu Phe Phe Ser Asn Lys Val Leu Tyr Leu Lys Asp Gly Ile Leu 
65                  70                  75                  80  


Tyr Leu Lys Asp Arg Arg Glu Lys Asn Gln Leu Gln Asn Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Asn Phe 
            100                 105                 110         


Leu Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Asn Asp Phe Glu Lys Lys Leu Asp Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Leu Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Ile Lys Lys Val Glu Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Phe Tyr Asn Tyr Tyr Lys Asp Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Ile Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Asn Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Thr Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Met 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asn Val Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asn Lys Glu Lys Leu Asn Asp Glu 
        275                 280                 285             


Asn Ile Lys Tyr Val Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Ser Phe Tyr Leu Gln Asp Gly Glu Ile Ala Ile Ser Asp Phe Ile 
        355                 360                 365             


Val Gly Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Thr Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Ile Lys Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Ile Ser Gly Glu Ile Asp Lys Leu Tyr Asp 
            420                 425                 430         


Asn Asn Lys Gln Asn Glu Val Lys Lys Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asn Ser Lys Lys Glu Ile Glu Asp Phe Phe Ser 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Thr Phe Lys Asn Ile Val 
                485                 490                 495     


Pro Ser Gln Ile Ser Lys Lys Met Phe Gln Asp Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Lys Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Asn Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Cys Ile Tyr Trp 
                565                 570                 575     


Lys Ile Pro Lys Ala Asn Asp Asn Asn Lys Thr Lys Glu Ile Thr Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ile Lys Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asn Leu Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Phe Tyr Met Ile Asp Ala Gly Asn Lys Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Ala Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Met 
    690                 695                 700                 


Tyr Ile Gly Asn Asp Glu Gln Ile Asn Thr Ser Leu Ala Gly Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Lys Ile Leu Lys Tyr Thr Glu Ser Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Ala Phe Ser Asp Gln Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Val Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Lys Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Ile Glu Ile Glu Glu Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Asn Asp Glu Lys Phe Asn Asp Glu Asp Tyr Lys 
        915                 920                 925             


Lys Tyr Glu Lys Ala Ile Arg Asn Ile Gln Gln Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Ser Leu Leu Leu 
945                 950                 955                 960 


Arg Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Asn Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Ser Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asp  Thr Glu Lys Ile Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Glu Leu  Lys Lys Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  Asn Ala Glu Val Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Val Lys Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Glu 
    1100                 1105                 1110             


Ile Gln  Ser Leu Lys Ser Glu  Glu Ile Val His Leu  Lys Lys Leu 
    1115                 1120                 1125             


Lys Leu  Lys Asp Asn Asp Lys  Lys Lys Glu Pro Ile  Lys Thr Tyr 
    1130                 1135                 1140             


Arg Asn  Ser Lys Glu Leu Cys  Lys Leu Val Lys Val  Met Phe Glu 
    1145                 1150                 1155             


Tyr Lys  Met Lys Glu Lys Lys  Ser Glu Asn 
    1160                 1165             


<210>  124
<211>  1181
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  124

Met Cys Met Lys Ile Thr Lys Ile Asp Gly Val Ser His Tyr Lys Lys 
1               5                   10                  15      


Gln Asp Lys Gly Ile Leu Lys Lys Lys Trp Lys Asp Leu Asp Glu Arg 
            20                  25                  30          


Lys Gln Arg Glu Lys Ile Glu Glu Arg Tyr Asn Lys Gln Ile Glu Ser 
        35                  40                  45              


Lys Ile Tyr Lys Glu Phe Phe Arg Leu Lys Asp Gly Lys Arg Ile Thr 
    50                  55                  60                  


Arg Glu Glu Lys Asp Gln Asn Ile Lys Ser Leu Tyr Phe Phe Ile Glu 
65                  70                  75                  80  


Glu Leu Tyr Leu Ser Lys Lys Asn Glu Glu Trp Glu Leu Lys Asn Ile 
                85                  90                  95      


Asn Leu Glu Ile Leu Asp Asp Lys Glu Arg Ile Ile Lys Gly Tyr Lys 
            100                 105                 110         


Phe Lys Glu Asp Val Tyr Phe Phe Lys Glu Gly Asp Lys Lys Tyr Tyr 
        115                 120                 125             


Leu Arg Thr Leu Leu Asn Asn Leu Ile Glu Lys Ile Gln Asn Glu Asn 
    130                 135                 140                 


Arg Asp Lys Val Arg Lys Asn Lys Glu Phe Ser Asp Leu Lys Glu Ile 
145                 150                 155                 160 


Phe Lys Lys Tyr Lys Asp Arg Lys Ile Lys Leu Leu Leu Glu Ser Ile 
                165                 170                 175     


Asn Asn Asn Lys Ile Asn Leu Glu Tyr Lys Lys Glu Asn Val Asn Glu 
            180                 185                 190         


Glu Ile Tyr Gly Ile Asn Pro Thr Asn Asp Arg Glu Met Thr Phe Tyr 
        195                 200                 205             


Glu Leu Leu Lys Glu Ile Ile Glu Lys Lys Asp Glu Gln Lys Ser Ile 
    210                 215                 220                 


Leu Glu Glu Lys Leu Asp Asn Phe Asp Ile Thr Asn Phe Leu Glu Asn 
225                 230                 235                 240 


Ile Glu Lys Ile Phe Asn Glu Glu Thr Glu Ile Asn Ile Ile Lys Gly 
                245                 250                 255     


Lys Val Leu Asn Glu Leu Arg Glu Tyr Ile Arg Glu Lys Glu Glu Asn 
            260                 265                 270         


Asn Ser Asp Tyr Lys Leu Lys Gln Ile Tyr Asn Leu Glu Leu Lys Lys 
        275                 280                 285             


Tyr Ile Glu Asn Asn Phe Ser Tyr Lys Lys Gln Lys Ser Lys Ser Lys 
    290                 295                 300                 


Asn Gly Lys Asn Asp Tyr Leu Tyr Leu Asn Phe Leu Lys Lys Ile Met 
305                 310                 315                 320 


Phe Ile Glu Glu Val Asp Glu Lys Lys Gly Ile Asn Lys Glu Lys Phe 
                325                 330                 335     


Lys Asn Lys Ile Asn Ser Asn Phe Lys Asn Leu Phe Val Gln His Ile 
            340                 345                 350         


Leu Val Tyr Gly Lys Leu Leu Tyr Tyr Lys Glu Asn Asp Glu Tyr Ile 
        355                 360                 365             


Lys Asn Thr Gly Gln Leu Glu Thr Lys Asp Leu Glu Tyr Ile Lys Thr 
    370                 375                 380                 


Lys Glu Thr Leu Ile Arg Lys Met Ala Val Leu Val Ser Phe Ala Ala 
385                 390                 395                 400 


Asn Ser Tyr Tyr Asn Leu Phe Gly Arg Val Ser Gly Asp Ile Leu Gly 
                405                 410                 415     


Thr Glu Val Val Lys Ser Ser Lys Thr Asn Val Ile Lys Val Gly Ser 
            420                 425                 430         


His Ile Phe Lys Glu Lys Met Leu Asn Tyr Phe Phe Asp Ser Glu Ile 
        435                 440                 445             


Phe Asp Ala Asn Lys Ile Val Glu Ile Leu Glu Ser Ile Ser Tyr Ser 
    450                 455                 460                 


Ile Tyr Asn Val Arg Asn Gly Val Gly His Phe Asn Lys Leu Ile Leu 
465                 470                 475                 480 


Gly Lys Tyr Lys Lys Lys Asp Ile Asn Ile Asn Lys Arg Val Glu Glu 
                485                 490                 495     


Asp Leu Asn Asn Ser Glu Glu Ile Lys Gly Tyr Phe Ile Lys Lys Arg 
            500                 505                 510         


Gly Glu Ile Glu Lys Lys Ile Lys Glu Arg Phe Leu Ser Asn Asn Leu 
        515                 520                 525             


Glu Tyr Tyr Tyr Ala Lys Glu Arg Ile Glu Asn Tyr Phe Glu Val Tyr 
    530                 535                 540                 


Glu Phe Glu Ile Leu Lys Glu Lys Ile Pro Phe Ala Pro Asn Phe Lys 
545                 550                 555                 560 


Arg Ile Ile Lys Lys Gly Glu Asp Leu Phe Asn Asn Lys Lys Asn Lys 
                565                 570                 575     


Lys Tyr Glu Tyr Phe Lys Asn Phe Asp Lys Asn Ser Ala Glu Glu Lys 
            580                 585                 590         


Lys Glu Phe Leu Lys Thr Arg Asn Phe Leu Leu Lys Glu Leu Tyr Tyr 
        595                 600                 605             


Asn Asn Phe Tyr Lys Glu Phe Leu Ser Lys Lys Glu Glu Phe Lys Lys 
    610                 615                 620                 


Ile Val Ile Glu Val Lys Glu Glu Lys Lys Asn Arg Gly Asn Asn Lys 
625                 630                 635                 640 


Lys Ser Gly Val Ser Phe Gln Ser Ile Asp Asp Tyr Asp Thr Lys Ile 
                645                 650                 655     


Asn Ile Ser Asp Tyr Ile Ala Ser Ile His Lys Lys Glu Met Glu Arg 
            660                 665                 670         


Val Glu Lys Tyr Asn Glu Glu Lys Gln Lys Asp Thr Ala Lys Tyr Ile 
        675                 680                 685             


Arg Asp Phe Val Glu Glu Ile Phe Leu Thr Gly Phe Ile Asn Tyr Leu 
    690                 695                 700                 


Glu Lys Asp Glu Arg Leu His Phe Leu Lys Glu Glu Phe Ser Val Leu 
705                 710                 715                 720 


Cys Asn Ser Asn Asn Asn Ile Ile Asp Phe Asn Val Asn Ile Asn Glu 
                725                 730                 735     


Glu Lys Ile Lys Glu Phe Leu Lys Glu Asn Asp Ser Lys Thr Leu Asn 
            740                 745                 750         


Leu Tyr Leu Phe Phe Asn Met Ile Asp Ser Lys Arg Ile Ser Glu Phe 
        755                 760                 765             


Arg Asn Glu Leu Ile Lys Tyr Lys Gln Phe Thr Lys Lys Arg Leu Asp 
    770                 775                 780                 


Glu Glu Lys Glu Phe Leu Gly Ile Lys Ile Glu Leu Tyr Glu Thr Leu 
785                 790                 795                 800 


Ile Glu Phe Val Ile Leu Thr Arg Glu Lys Leu Asp Thr Lys Lys Ser 
                805                 810                 815     


Glu Glu Thr Asp Ala Trp Leu Val Asp Lys Leu Tyr Val Lys Glu Asn 
            820                 825                 830         


Asn Ala Tyr Lys Glu Tyr Glu Glu Ile Leu Lys Leu Phe Val Asp Glu 
        835                 840                 845             


Lys Ile Leu Ser Ser Lys Glu Ala Pro Tyr Tyr Ala Thr Asp Asn Lys 
    850                 855                 860                 


Thr Pro Ile Leu Leu Ser Asn Phe Glu Lys Thr Arg Lys Tyr Gly Thr 
865                 870                 875                 880 


Gln Ser Phe Leu Ser Glu Ile Gln Ser Asn Tyr Lys Tyr Ser Lys Val 
                885                 890                 895     


Glu Lys Glu Asn Ile Glu Asp Tyr Asn Lys Lys Glu Glu Ile Glu Lys 
            900                 905                 910         


Lys Glu Lys Ser Asn Ile Glu Lys Leu His Asp Leu Lys Val Glu Leu 
        915                 920                 925             


His Lys Lys Trp Glu Lys Asn Lys Ile Thr Glu Lys Glu Ile Lys Lys 
    930                 935                 940                 


Tyr Ser Asp Thr Ile Lys Glu Ile Arg Glu Tyr Asn Tyr Leu Lys Asn 
945                 950                 955                 960 


Lys Glu Glu Leu Gln Asn Val Tyr Leu Leu His Glu Ile Leu Ser Asp 
                965                 970                 975     


Leu Leu Ala Arg Asn Val Ala Phe Phe Asn Lys Trp Glu Arg Asp Phe 
            980                 985                 990         


Lys Phe Ile Val Ile Ala Ile Lys  Gln Phe Leu Arg Glu  Asn Asp Lys 
        995                 1000                 1005             


Gly Lys  Val Asn Glu Phe Leu  Asn Pro Pro Asp Asp  Ser Asn Gly 
    1010                 1015                 1020             


Lys Lys  Val Tyr Phe Ser Val  Ser Arg Tyr Lys Asn  Thr Val Glu 
    1025                 1030                 1035             


Asn Ile  Asp Gly Ile His Lys  Asn Phe Met Asn Leu  Ile Phe Leu 
    1040                 1045                 1050             


Asn Asn  Lys Phe Met Asn Arg  Lys Ile Asn Arg Ile  Asn Cys Thr 
    1055                 1060                 1065             


Ile Trp  Val Tyr Phe Arg Asn  Tyr Ile Ala His Phe  Val Tyr Leu 
    1070                 1075                 1080             


His Thr  Lys Asn Glu Lys Ile  Ser Leu Ile Asn Gln  Ile Asn Leu 
    1085                 1090                 1095             


Leu Ile  Lys Leu Phe Ser Tyr  Asp Lys Lys Val Gln  Asn His Ile 
    1100                 1105                 1110             


Leu Lys  Ser Thr Lys Thr Leu  Leu Glu Lys Tyr Asn  Ile Gln Ile 
    1115                 1120                 1125             


Asn Phe  Glu Ile Ser Asn Asp  Lys Asn Glu Val Phe  Lys Tyr Lys 
    1130                 1135                 1140             


Ile Lys  Asp Arg Leu Tyr Ser  Lys Lys Gly Lys Met  Leu Gly Lys 
    1145                 1150                 1155             


Asn Asn  Lys Phe Glu Ile Leu  Glu Lys Glu Phe Leu  Glu Asn Val 
    1160                 1165                 1170             


Lys Thr  Leu Leu Glu Cys Ser  Lys 
    1175                 1180     


<210>  125
<211>  1143
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  125

Met Arg Val Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Val Tyr Ser Gly 
            20                  25                  30          


Gln Pro Val Ser Asn Glu Thr Cys Asn Ile Leu Pro Glu Lys Lys Arg 
        35                  40                  45              


Gln Ser Phe Asp Leu Ser Ile Glu Asn Lys Thr Leu Lys Arg Arg Asp 
    50                  55                  60                  


Asp Val Asp Lys Thr Lys Lys Gly Lys Tyr Asp Ile Val Arg Lys Ile 
65                  70                  75                  80  


Ile Lys Tyr Gly Glu Leu Pro Gln Ser Ile Asn Asp Val Asp Ile Leu 
                85                  90                  95      


Glu Phe Leu Asn His Lys Phe Gln Lys Pro Val Lys Tyr Trp Lys Asn 
            100                 105                 110         


Gly Lys Glu Glu Ser Phe Asn Leu Thr Leu Leu Ile Val Glu Ala Val 
        115                 120                 125             


Lys Thr Gln Asp Arg Gln Lys Leu Gln Pro Tyr Tyr Asp Trp Lys Thr 
    130                 135                 140                 


Trp Tyr Ile Gln Thr Lys Ser Asp Leu Leu Lys Lys Ser Ile Glu Asn 
145                 150                 155                 160 


Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg Lys Lys Ala Leu 
                165                 170                 175     


Leu Ala Trp Glu Thr Glu Phe Thr Thr Ser Gly Lys Ile Asp Leu Thr 
            180                 185                 190         


His Tyr His Lys Val Tyr Met Thr Asp Val Leu Cys Thr Ala Leu Gln 
        195                 200                 205             


Lys Val Glu Pro Ser Thr Asp Lys Lys Gly Lys Ile Asn Thr Asn Ala 
    210                 215                 220                 


Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Thr His Gln Pro Ala Ile 
225                 230                 235                 240 


Phe Gly Thr Arg Gln Ala Pro Asn Asn Val Asn Arg Ala Asp Asp Arg 
                245                 250                 255     


Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu Glu His Tyr Phe 
            260                 265                 270         


Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Ala Asp Asp Ile Glu His 
        275                 280                 285             


Tyr Leu Lys Thr Gln Thr Leu Lys Thr Thr Ile Glu Lys Gln Leu Val 
    290                 295                 300                 


Asn Ala Ile Arg Ala Asn Ile Ile Gln Gln Gly Lys Thr Asn His His 
305                 310                 315                 320 


Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile Arg Ile Lys Thr 
                325                 330                 335     


Asn Glu Ala Phe Val Leu Asn Leu Thr Gly Thr Cys Ala Phe Ala Ala 
            340                 345                 350         


Asn Asn Ile Arg Asn Met Val Asp Asn Glu Gln Thr Asn Asp Ile Leu 
        355                 360                 365             


Gly Lys Gly Asp Phe Ile Lys Ser Leu Leu Lys Asp Asn Thr Asn Gly 
    370                 375                 380                 


Gln Leu Tyr Ser Phe Phe Phe Gly Glu Ser Leu Ser Thr Asn Lys Ala 
385                 390                 395                 400 


Glu Lys Glu Thr Gln Leu Trp Gly Ile Arg Gly Ala Val Gln Gln Ile 
                405                 410                 415     


Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu Lys Thr Val Phe 
            420                 425                 430         


Asn Ile Ser Asn Phe Glu Asn Pro Thr Ile Thr Asp Pro Lys Gln Gln 
        435                 440                 445             


Thr Asn Tyr Ala Asp Thr Ile Tyr Lys Ala Leu Phe Ile Lys Glu Leu 
    450                 455                 460                 


Glu Lys Ile Pro Asn Ala Phe Ala Gln Gln Leu Lys Thr Gly Gly Ala 
465                 470                 475                 480 


Leu Ser Tyr Tyr Thr Ile Glu Asn Leu Lys Ser Leu Leu Thr Thr Phe 
                485                 490                 495     


Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala Pro Gly Phe Lys 
            500                 505                 510         


Lys Val Phe Asn Gly Gly Ile Asn Tyr Gln Asn Ala Lys Gln Asp Glu 
        515                 520                 525             


Ser Phe Tyr Glu Leu Met Leu Glu Arg Tyr Leu Arg Lys Glu Asn Phe 
    530                 535                 540                 


Ala Glu Glu Ala Tyr Asn Ala Arg Tyr Phe Leu Leu Lys Leu Ile Tyr 
545                 550                 555                 560 


Asn Asn Leu Phe Leu Pro Gly Phe Thr Arg Asp Arg Lys Ala Phe Ala 
                565                 570                 575     


Asp Ser Val Gly Phe Val Gln Met Gln Asn Lys Lys Gln Ala Glu Lys 
            580                 585                 590         


Val Asn Pro Lys Lys Arg Glu Ala Tyr Ala Phe Glu Ala Val Arg Pro 
        595                 600                 605             


Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala Tyr Val Gln Ser 
    610                 615                 620                 


Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys Ala Thr Asp Glu 
625                 630                 635                 640 


Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val Phe Val Lys Gly 
                645                 650                 655     


Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe Val Gln Val Pro 
            660                 665                 670         


Gln Pro Gln Leu Thr Ala Thr Ala Ser Asn Gln Gln Lys Ala Asp Lys 
        675                 680                 685             


Leu Asn Gln Leu Glu Ala Ser Ile Thr Ala Asp Cys Lys Leu Thr Pro 
    690                 695                 700                 


Gln Tyr Ala Lys Ala Asp Asn Ala Thr His Ile Ala Phe Tyr Val Phe 
705                 710                 715                 720 


Cys Lys Leu Leu Asp Ala Gly His Leu Ser Asn Leu Arg Asn Glu Leu 
                725                 730                 735     


Ile Lys Phe Arg Glu Ser Val Asn Glu Phe Lys Phe His His Leu Leu 
            740                 745                 750         


Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val Val Pro Thr Asp 
        755                 760                 765             


Tyr Arg Asp Leu Tyr Ser Ser Glu Ala Asp Cys Leu Ala Arg Leu Arg 
    770                 775                 780                 


Pro Phe Ile Glu Gln Gly Ala Asp Ile Thr Asn Trp Ser Asp Leu Phe 
785                 790                 795                 800 


Val Gln Ser Asp Lys His Ser Pro Val Ile His Ala Asn Ile Glu Leu 
                805                 810                 815     


Ser Val Lys Tyr Gly Thr Thr Lys Leu Leu Glu Gln Ile Ile Asn Lys 
            820                 825                 830         


Asp Pro Gln Phe Lys Thr Thr Glu Ala Asn Phe Thr Ala Trp Asn Thr 
        835                 840                 845             


Ala Gln Lys Ser Ile Glu Gln Leu Ile Lys Gln Arg Glu Asp His His 
    850                 855                 860                 


Glu Gln Trp Val Lys Ala Lys Asn Ala Asp Asp Lys Glu Lys Gln Glu 
865                 870                 875                 880 


Arg Lys Arg Glu Lys Ser Asn Phe Ala Gln Lys Phe Ile Glu Lys His 
                885                 890                 895     


Gly Asp Asp Tyr Leu Asp Ile Cys Asp Tyr Ile Asn Thr Tyr Asn Trp 
            900                 905                 910         


Leu Asp Asn Lys Met His Phe Val His Leu Asn Arg Leu His Gly Leu 
        915                 920                 925             


Thr Ile Glu Leu Leu Gly Arg Met Ala Gly Phe Val Ala Leu Phe Asp 
    930                 935                 940                 


Arg Asp Phe Gln Met Leu Asp Ala Lys Arg Ile Ser Asp Leu Tyr Gln 
945                 950                 955                 960 


Leu Lys Ser Phe Ile Ser Phe Arg Glu Ile Thr Ser Glu Leu Asp Lys 
                965                 970                 975     


Asn Asn Asp Ile Thr Glu Ile Asn Leu Ile Lys Asp Lys Glu Ile Ile 
            980                 985                 990         


Lys Arg Asp Gly Thr Pro Ile Thr  Glu Ala Asp Arg Asn  Ser Leu Lys 
        995                 1000                 1005             


Ser Cys  Ile Gln Ser Lys Arg  Glu Tyr Tyr Gln Lys  Thr Tyr Phe 
    1010                 1015                 1020             


Lys Glu  His Thr Asn Pro Phe  Thr Asp Arg Asn Tyr  Ile Ala His 
    1025                 1030                 1035             


Phe Asn  Tyr Leu Ser Thr Asn  Thr Gly Asn His Ser  Leu Ile Lys 
    1040                 1045                 1050             


Leu Ile  Asn Lys Leu Arg Asp  Leu Leu His Tyr Asp  Arg Lys Leu 
    1055                 1060                 1065             


Lys Asn  Ala Val Ser Lys Ala  Phe Ile Asp Leu Phe  Asp Lys His 
    1070                 1075                 1080             


Gly Met  Ile Leu Lys Leu Lys  Leu Asn Thr Asp His  Gln Leu Glu 
    1085                 1090                 1095             


Val Glu  Ser Leu Glu Pro Lys  Lys Ile Tyr His Leu  Gly Ser Ser 
    1100                 1105                 1110             


Ala Lys  Asp Lys Pro Glu Tyr  Gln Tyr Cys Thr Asn  Gln Val Met 
    1115                 1120                 1125             


Met Ala  Tyr Cys Asn Met Cys  Arg Ser Leu Leu Glu  Met Lys Lys 
    1130                 1135                 1140             


<210>  126
<211>  1101
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  126

Met Arg Ile Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Ile Tyr Ser Glu 
            20                  25                  30          


Gln Ala Val Ser Asn Glu Thr Asn Asn Ile Leu Pro Val Lys Lys Met 
        35                  40                  45              


Asp Ser Phe Asn Leu Ser Ile Leu Asn Lys Thr Ile Ile Lys Phe Glu 
    50                  55                  60                  


Thr Val Lys Lys Gln Lys Leu Asn Leu Asp Gln Tyr Lys Ile Val Glu 
65                  70                  75                  80  


Lys Ile Phe Lys Tyr Pro Lys Gln Glu Leu Pro Lys Gln Ile Asn Ala 
                85                  90                  95      


Glu Glu Ile Leu Gln Phe Leu Asn His Lys Phe Gln Glu Pro Val Lys 
            100                 105                 110         


Tyr Trp Lys Asn Gly Lys Glu Glu Ser Phe Asn Leu Thr Leu Leu Ile 
        115                 120                 125             


Val Glu Ala Val Lys Thr Gln Glu Lys Arg Lys Leu Gln Pro Tyr Tyr 
    130                 135                 140                 


Asp Trp Lys Thr Trp Tyr Ile Gln Thr Lys Ser Asp Leu Leu Lys Lys 
145                 150                 155                 160 


Ser Ile Glu Asn Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg 
                165                 170                 175     


Lys Lys Ala Leu Leu Ala Trp Glu Thr Glu Phe Thr Thr Ser Gly Ser 
            180                 185                 190         


Ile Asp Leu Thr His Phe His Lys Val Tyr Met Thr Asp Val Leu Cys 
        195                 200                 205             


Thr Ala Leu Gln Lys Val Glu Pro Ser Ala Asp Glu Arg Gly Lys Met 
    210                 215                 220                 


Asn Ser Asn Ala Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Asn His 
225                 230                 235                 240 


Gln Pro Ala Ile Phe Gly Thr Arg Glu Ala Pro Asn Glu Val Asn Arg 
                245                 250                 255     


Ala Asp Asn Gln Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu 
            260                 265                 270         


Glu His Tyr Phe Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Ala Asp 
        275                 280                 285             


Asp Ile Ser His Tyr Leu Lys Ala Gln Thr Leu Lys Thr Thr Ile Glu 
    290                 295                 300                 


Lys Gln Leu Val Asn Ala Ile Arg Ala Asn Ile Ile Gln Gln Gly Lys 
305                 310                 315                 320 


Thr Asn His His Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile 
                325                 330                 335     


Arg Ile Lys Thr Asn Glu Ala Phe Val Leu Asn Leu Ile Gly Thr Cys 
            340                 345                 350         


Ala Phe Ala Ala Asn Asn Ile Arg Asn Met Val Asp Lys Glu Gln Ile 
        355                 360                 365             


Ser Asp Ile Leu Gly Lys Arg Glu Phe Ile Asp Ser Leu Thr Lys Ser 
    370                 375                 380                 


Arg Ile Ser Ser Gln Leu Tyr Ser Phe Phe Phe Gly Glu Asn Leu Ser 
385                 390                 395                 400 


Thr Asn Lys Ala Glu Lys Glu Thr Gln Leu Trp Gly Ile Arg Gly Ala 
                405                 410                 415     


Val Gln Gln Ile Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu 
            420                 425                 430         


Thr Thr Ile Phe Asn Ile Cys Lys Phe Glu Asn Pro Thr Asp Ala Asp 
        435                 440                 445             


Pro Lys Gln Gln Thr Asn Tyr Val Asp Ser Ile Tyr Lys Thr Leu Phe 
    450                 455                 460                 


Ile Lys Glu Leu Glu Lys Ile Pro Glu Ala Phe Ala Gln Gln Leu Lys 
465                 470                 475                 480 


Thr Gly Gly Ala Leu Ser Tyr Tyr Thr Val Glu Asn Leu Lys Thr Leu 
                485                 490                 495     


Leu Thr Thr Phe Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala 
            500                 505                 510         


Pro Gly Phe Lys Lys Val Leu Asn Gly Gly Ile Asn Tyr Gln Asn Ala 
        515                 520                 525             


Lys Gln Asp Glu Ser Phe Tyr Glu Leu Met Leu Glu Arg Tyr Leu Arg 
    530                 535                 540                 


Lys Glu Asn Phe Ala Glu Glu Ala Tyr Asn Ala Arg Tyr Phe Leu Leu 
545                 550                 555                 560 


Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Lys Phe Thr Ala Asp Arg 
                565                 570                 575     


Lys Ala Phe Ala Asp Ser Val Gly Phe Val Gln Leu Gln Asn Arg Lys 
            580                 585                 590         


Gln Ala Glu Asn Ser Lys Arg Pro Lys Ala Phe Ala Phe Glu Ala Val 
        595                 600                 605             


Arg Pro Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala Tyr Val 
    610                 615                 620                 


Gln Ser Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys Ala Thr 
625                 630                 635                 640 


Asp Glu Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val Phe Ile 
                645                 650                 655     


Lys Gly Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe Val Gln 
            660                 665                 670         


Val Pro Gln Pro Gln Leu Thr Thr Thr Asp Ser Asn Gln Gln Lys Ala 
        675                 680                 685             


Asp Lys Leu Asn Gln Leu Glu Ala Ser Ile Thr Ala Asp Cys Lys Leu 
    690                 695                 700                 


Thr Ala Gln Tyr Ala Lys Thr Asp Asp Ala Thr His Ile Ala Phe Tyr 
705                 710                 715                 720 


Val Phe Cys Lys Leu Leu Asp Ala Gly His Leu Ser Asn Leu Arg Asn 
                725                 730                 735     


Glu Leu Ile Lys Phe Arg Gly Ser Val Lys Asp Phe Asp Phe His His 
            740                 745                 750         


Leu Leu Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val Val Pro 
        755                 760                 765             


Thr Asp Tyr Arg Asp Leu Tyr Ser Ser Gly Ala Asp Cys Leu Ala Arg 
    770                 775                 780                 


Leu Arg Pro Phe Ile Glu Gln Gly Ala Asp Ile Lys Asn Trp Ser Asp 
785                 790                 795                 800 


Leu Tyr Val Gln Thr Asp Lys Gln Thr Pro Val Ile His Ala Gly Ile 
                805                 810                 815     


Glu Leu Ser Val Lys Tyr Gly Thr Thr Ala Leu Leu Glu Gln Leu Ile 
            820                 825                 830         


Thr Cys Asn Pro Lys Phe Arg Val Met Glu Asp Asn Phe Thr Lys Trp 
        835                 840                 845             


Ser Ala Gln Lys Lys Glu Ile Glu Glu Lys Val Asn Lys His Thr Asn 
    850                 855                 860                 


Leu His Gln Gln Trp Val Glu Ala Lys Glu Lys Asp Asp Arg Glu Arg 
865                 870                 875                 880 


Val Lys Ser Lys Lys Asn Phe Val Arg Glu Tyr Val Lys Lys Asn Tyr 
                885                 890                 895     


Val Asp Tyr Ile Asn Asn Cys Ile Glu Ile Asn Asn Tyr Asn Trp Leu 
            900                 905                 910         


Asp Asn Lys Leu His Phe Val His Leu Asn His Leu His His Leu Thr 
        915                 920                 925             


Ile Asp Ile Leu Gly Arg Met Ala Gly Phe Val Ala Leu Trp Glu Arg 
    930                 935                 940                 


Asp Phe Gln Tyr Ile Thr Lys Tyr Thr Ala Ala Lys Glu Gly Thr Asp 
945                 950                 955                 960 


Ala Leu Ser Phe Asp Gly Gly Leu Pro Arg Leu Lys Asp Lys Gln Glu 
                965                 970                 975     


Tyr Tyr Asn Lys Leu Phe Leu Ser Asp Lys Tyr Thr Lys Val Arg Asn 
            980                 985                 990         


His Ile Ala His Phe Asn Tyr Leu  Thr Lys Asp Ala Ala  Asp Phe Ala 
        995                 1000                 1005             


Leu Leu  Asp Leu Ile Asn Glu  Leu Arg Glu Leu Leu  His Tyr Gly 
    1010                 1015                 1020             


Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ala Phe Ile  Asp Leu Phe 
    1025                 1030                 1035             


Glu Lys  His Gly Met Ile Leu  Lys Leu Lys Leu Asn  Thr Asp His 
    1040                 1045                 1050             


Gln Leu  Val Val Glu Ser Ile  Glu Pro Lys Lys Ile  Tyr His Leu 
    1055                 1060                 1065             


Gly Ser  Thr Ala Lys Asp Lys  Pro Glu Tyr Gln Tyr  Thr Thr Asn 
    1070                 1075                 1080             


Gln Val  Met Thr Val Tyr Cys  Asn Met Cys Arg Ser  Leu Leu Glu 
    1085                 1090                 1095             


Met Lys  Lys 
    1100     


<210>  127
<211>  1144
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  127

Met Arg Val Ser Lys Val Lys Val Lys Val Gly Trp Gly Arg Asn Ser 
1               5                   10                  15      


Glu Arg Met Val Phe Met Arg Arg Thr Ser Lys Ile Gly Ser Leu Val 
            20                  25                  30          


Tyr Glu Asp Glu Gln Arg Ser Gly Lys Pro Glu Thr Asp Asp Lys Thr 
        35                  40                  45              


Glu Ser Ile Leu Pro Asp Lys Lys Arg Glu Ser Phe Ile Leu Ser Ile 
    50                  55                  60                  


Val Asn Lys Thr Ile Pro Lys Lys Glu Ile Val Lys Lys Asn Leu Gly 
65                  70                  75                  80  


Lys Gly Phe Val Lys Glu Tyr Tyr Asp Ala Ile Ala Gly Ile Ile Asn 
                85                  90                  95      


Ser Phe Leu Glu Lys Lys Ile Val Asp Arg Lys His Tyr Ile Ile Val 
            100                 105                 110         


Asn Lys Leu Thr Glu Glu Glu Ile Lys Gln Tyr Leu Asn His Arg Phe 
        115                 120                 125             


Gln Glu Ala Asn Tyr Lys Tyr Val Arg Asp Lys Glu Glu Val Asn Phe 
    130                 135                 140                 


Asn Leu Ser Lys Leu Leu Lys Glu Ser Ala Lys Ser Asn Ser Thr Ala 
145                 150                 155                 160 


Pro Leu Gln Pro Tyr Lys Glu Trp Ala Glu Trp His Ile Glu Thr Lys 
                165                 170                 175     


Ser Val Arg Leu Ile Arg Ser Ile Gln Asn Asn Arg Leu Val Ile Asp 
            180                 185                 190         


Thr Gln Glu Glu Ala Glu Asn Ile Ser Pro Arg Lys Arg Ala Leu Leu 
        195                 200                 205             


Lys Trp Glu Asn Glu Phe Leu Leu Ser His Lys Leu Asp Leu Gln Asp 
    210                 215                 220                 


Met Glu Lys Thr Tyr Leu Ile Asp Asp Leu Ile His Ala Leu His Glu 
225                 230                 235                 240 


Val Thr Tyr Thr Ile Ser Asp Lys Gly Phe Ile Asn Gly Asn Glu Tyr 
                245                 250                 255     


His Arg Phe Leu Lys Lys Ala Leu Gln Ser His Gln Gln Asn Ile Phe 
            260                 265                 270         


Gly Ser Arg Glu Thr Pro Asn Lys Val Asn Arg Glu Asn Ala Glu Leu 
        275                 280                 285             


Tyr Ser Tyr Asn Met Glu Val Val Lys Tyr Leu Glu His Tyr Phe Pro 
    290                 295                 300                 


Ile Lys Lys Thr Asn Arg Arg Asn Thr Pro Glu Val Lys Asp Tyr Tyr 
305                 310                 315                 320 


Leu Asn Gly Ile Lys Asp Arg Val Arg Lys Gln Leu Glu Asn Ala Val 
                325                 330                 335     


Arg Asn Asn Leu Val Arg Gln Gly Lys Tyr Thr Leu His Thr Leu Thr 
            340                 345                 350         


Thr Asp Thr Ala Asn Ser Asp Asn Leu Ser Lys Ile Lys Ala Asp Glu 
        355                 360                 365             


Gly Phe Ala Leu Thr Met Leu Asn Gln Cys Ala Phe Ala Ala Asn Asn 
    370                 375                 380                 


Val Arg Asn Ile Ile Asp Pro Thr Gln Val Gly Asp Ile Ile Gly Lys 
385                 390                 395                 400 


Asp Asp Phe Ile Tyr Ser Ile Ser Asp Arg His Arg Ile Pro Ser Glu 
                405                 410                 415     


Gln Val Phe Pro Leu Phe Phe Gly Leu Asp Ala Thr Leu Lys Gln Asp 
            420                 425                 430         


Tyr Val Asn His Leu Trp Ala Met Arg Gly Ala Val Ala Asn Ile Arg 
        435                 440                 445             


Asn Asn Ile Ile His Tyr Arg Ala Asn Ala Leu Asp Thr Ile Phe Asn 
    450                 455                 460                 


Ile Glu Lys Tyr Glu Leu Lys Asn Lys Asp Glu Tyr Lys Tyr Phe His 
465                 470                 475                 480 


Gln Asp Thr Ser Phe Gly Thr Leu Leu Gln Ala Glu Met Glu Asn Val 
                485                 490                 495     


Ser Glu Ser Leu Ala Lys Gln Leu Met Thr Gly Asn Val Leu Glu Tyr 
            500                 505                 510         


Tyr Pro Met Gln Glu Leu Lys Ser Phe Phe Ser Lys Asn Ser Ile Ser 
        515                 520                 525             


Leu Tyr Arg Ser Val Ile Pro Phe Ala Pro Gly Phe Lys Arg Val Met 
    530                 535                 540                 


Lys Lys Gly Glu Asn Tyr Gln Asn Ala Asp Lys Lys Glu Asn Lys Lys 
545                 550                 555                 560 


Asp Ser Lys Asp Gly Tyr Tyr Asp Leu Lys Ile Glu Ser Phe Leu Pro 
                565                 570                 575     


Gln Glu Ser Phe Thr Lys Glu Ala Tyr Asp Ala Arg Tyr Phe Leu Leu 
            580                 585                 590         


Lys Leu Ile Tyr Asn Asn Ile Phe Leu Pro Lys Phe Thr Glu Ser Thr 
        595                 600                 605             


Asp Trp Phe Lys Ser Thr Val Asn Gly Val Ile Ala Leu Asn Arg Glu 
    610                 615                 620                 


Glu Asn Val Arg Lys Gly Lys Lys His Lys Ile Ala Phe Ala Glu Ile 
625                 630                 635                 640 


Arg Leu Met Asp Ser Ile Asp Thr Ile Gly Thr Tyr Ala Ala Tyr Leu 
                645                 650                 655     


Gln Ser Cys Ala Ile Ile Glu Ala Asn Lys Lys Pro Asp Ala Ala Lys 
            660                 665                 670         


Asp Glu Thr Val Leu Leu Asn Phe Glu Lys Leu Ile Leu Gln Ile Phe 
        675                 680                 685             


Ile Lys Gly Phe Asp Asp Phe Leu Arg Arg Asn Gly Val Leu Lys Phe 
    690                 695                 700                 


Val Gln Gln Pro Ser Leu Gln Phe Lys Ser Gly Ala Lys Asp Glu Thr 
705                 710                 715                 720 


Thr Gln Arg Lys Asp Trp Ala Lys Glu Ile Glu Gly Ser Leu Arg Ala 
                725                 730                 735     


Pro Val Asn Glu Ile Asn Pro Thr Glu Ser Ser His Ile Ser Phe Tyr 
            740                 745                 750         


Val Phe Cys Lys Leu Leu Asp Ala Ser His Leu Asn Asp Leu Arg Asn 
        755                 760                 765             


Glu Leu Ile Lys Tyr Tyr Arg Ser Gln Ser His Arg Pro Gln Lys Ile 
    770                 775                 780                 


Lys Asn Ile Lys Tyr Leu Leu Ser Ile Ile Glu Leu Cys Leu Leu Ser 
785                 790                 795                 800 


Val Asp Ala Ser Glu Leu Asn Lys Leu Phe Thr Asp Ala Asn Asn Ser 
                805                 810                 815     


Ile Asn Asp Arg Leu Leu Ala Phe Leu Glu Lys Asn Lys Thr Val Thr 
            820                 825                 830         


Asp Tyr Glu Asp Leu Tyr Thr Gln Ser Asp Asn Glu Thr Met Val Leu 
        835                 840                 845             


His Arg Thr Ile Ala Lys Thr Tyr Lys Tyr Gly Thr Arg Lys Val Leu 
    850                 855                 860                 


Glu Gln Val Ile Asp Ser Asn Pro Ser Tyr Arg Val Thr Val Gly Glu 
865                 870                 875                 880 


Tyr Gln Glu Trp Arg Ser Leu Lys Glu Asn Val Glu Glu Trp Ile Ala 
                885                 890                 895     


Arg Arg Glu Lys Leu His Ala Lys Trp Val Lys Val Glu Arg Val Pro 
            900                 905                 910         


Lys Met Lys Glu Gly Glu Met Thr Gly Asp Met Lys Glu Tyr Val Lys 
        915                 920                 925             


Ile Cys Ser Ala Ile Asp Arg Tyr Asn Trp Leu Asp Asn Lys Val His 
    930                 935                 940                 


Leu Glu His Ile Asn Lys Leu His Asn Leu Thr Ile Asp Ile Leu Gly 
945                 950                 955                 960 


Arg Met Ala Gly Phe Asn Thr Leu Phe Glu Arg Asp Leu Gln Tyr Tyr 
                965                 970                 975     


Cys Asn Cys Asn Glu Lys Val Arg Ser Leu Leu Lys Pro Glu Ser Ser 
            980                 985                 990         


Glu Gly Phe Asp Phe Ser Lys Gly  Leu Pro Lys Phe Thr  Glu Glu Gln 
        995                 1000                 1005             


Asn Ser  Ile Leu Phe Gln Thr  Phe Leu Val Glu Gly  Tyr Arg Asp 
    1010                 1015                 1020             


Thr Arg  Asn Phe Val Ala His  Phe Asn Phe Leu Asn  Ser Phe Glu 
    1025                 1030                 1035             


Asp Ser  Tyr Ser Lys Asn Arg  Tyr Ser Leu Ile Asp  Val Ile Asn 
    1040                 1045                 1050             


Arg Leu  Arg Lys Gln Phe Lys  Tyr Asp Arg Lys Leu  Lys Asn Ala 
    1055                 1060                 1065             


Val Ser  Lys Ala Ile Ile Lys  Leu Phe Glu Lys His  Gly Met Val 
    1070                 1075                 1080             


Leu Ile  Leu Ser Phe Pro Glu  Glu Ala His Glu Leu  Val Val Lys 
    1085                 1090                 1095             


Asp Val  Phe Pro Arg Lys Ile  Thr His Phe Ser Lys  Leu Lys Leu 
    1100                 1105                 1110             


Asp Lys  Lys Ile Glu Gln Lys  Pro Lys Val Glu Thr  Asp Met Val 
    1115                 1120                 1125             


Pro Lys  Glu Phe Cys Ala Met  Cys Lys Ser Leu Leu  Glu Leu Asn 
    1130                 1135                 1140             


Lys 
    


<210>  128
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  128

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Leu Tyr Gln Ile Val  Ser Ala Phe Asn Phe  Gly Ser Lys 
    1205                 1210                 1215             


Leu Leu  Tyr Ile Ser Glu Asp  Gly Arg Trp Lys Met  Ala Gly Gly 
    1220                 1225                 1230             


Ala Phe  Pro Gly Lys Tyr Gly  Arg Phe Glu Asn Asp  Tyr Asn His 
    1235                 1240                 1245             


Arg Thr  Ser Leu Ser Lys Val  Ile Arg Leu Phe Glu  Asn Glu Ser 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ile Ile Tyr  Trp Arg Asp Tyr Val  Asp His Met 
    1265                 1270                 1275             


Lys Tyr  Tyr Val Asn Gln Asn  Gln Ser Ile Met Glu  Ile Tyr Ser 
    1280                 1285                 1290             


Ala Phe  Tyr Ser Lys Val Leu  Gly Tyr Ser Ala Lys  Leu Arg Lys 
    1295                 1300                 1305             


Ser Val  Val Phe Asn Leu Gln  Ala Ala Leu Glu Lys  His His Ile 
    1310                 1315                 1320             


Asn Pro  Glu Cys Ile Trp Met  Thr Ser Asp Gly Lys  Cys Ala Asp 
    1325                 1330                 1335             


Ile Lys  Leu Met Lys Asn Leu  Glu Ser Gln Lys Phe  Thr Tyr Lys 
    1340                 1345                 1350             


Leu Ala  Lys Arg Glu Gly Glu  Lys Thr Glu Arg Lys  Ile Cys Met 
    1355                 1360                 1365             


Asn Ala  Leu Asn Glu Asn Phe  Leu Lys Thr Ile Arg  Thr Ser Leu 
    1370                 1375                 1380             


Glu Tyr  Lys Lys 
    1385         


<210>  129
<211>  1380
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  129

Met Lys Leu Ser Lys Glu Lys Gln Ile Arg Ser Ala Val Ala Asn Lys 
1               5                   10                  15      


Glu Lys Asn Thr Glu Gly Val Leu Tyr Arg Phe Pro Gly Ala Asp Ile 
            20                  25                  30          


Gly Gly Val Gln Ala Gln Met Leu Val Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Leu Gly Asn Lys Pro Lys Glu 
    50                  55                  60                  


Trp Met Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Lys Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Ala Ile Asn Asp Ile Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Lys Glu Ala Asp Lys Lys Ile Arg Asn Met Ser Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Asn Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Gly Asn Gln Glu Phe Asp Ser Ile Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp Arg 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Asp Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Ser Ile Gln Asp Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Ile Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Glu Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Ala Glu Lys Asp Gly Leu Asn Glu Phe Met Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Glu Glu Lys Arg Ala Glu Val Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Ser His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Val Asn Lys Glu Lys Phe Tyr Val Trp 
305                 310                 315                 320 


Lys Lys His Glu Cys Gly Lys Lys Glu Asn Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Val Glu Ala Glu Ala Glu Ser Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Ile Phe Phe Glu Asn Asp Thr Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Thr Gly Thr Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Lys Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asn Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Gln Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Leu 
            660                 665                 670         


Val Arg Thr Val Phe Pro Glu Tyr Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Asn Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Arg Thr Leu Arg Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Lys 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Glu Asn Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Cys Ala Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu 
        915                 920                 925             


Leu Ser Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Lys Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Lys Phe Ser Glu Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Thr Asn Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Gly  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Glu Lys Pro Glu  Glu Tyr Glu Lys Ile  Glu Ala Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Ile  Tyr Ala Pro Glu Lys  Asn Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Gln Gly Arg Val Gly  Ala Lys Val 
    1145                 1150                 1155             


Thr Ser  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Glu Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Met Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Val Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Val Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Asp  Asp Glu Asp Ala Asp  Thr Lys Lys Pro Val  Ile Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Glu  Asp Glu Asp 
    1325                 1330                 1335             


Lys Gln  Lys Gly Lys Glu Asn  Arg Gly Lys Lys Asn  Thr Glu Thr 
    1340                 1345                 1350             


Arg Ser  Asp Ala Glu Lys Asn  Asn Asn Asp Arg Leu  Ser Tyr Asn 
    1355                 1360                 1365             


Pro Phe  Ala Asn Phe Asp Phe  Lys Leu Pro Asn Lys  
    1370                 1375                 1380 


<210>  130
<211>  1330
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  130

Met Lys Arg Glu Lys Asn Ile Thr Ile Met Lys Ile Ser Lys Val Asn 
1               5                   10                  15      


His Arg Arg Thr Ala Val Ala Leu Asn Gly Asp Lys Ser Glu Leu Gly 
            20                  25                  30          


Gly Ile Leu Tyr Glu Ala Pro Val Gln Lys Asp Lys Asn Gly Asn Tyr 
        35                  40                  45              


Asn Asp Val Ile Ala Glu Thr Gly Lys Val Val Asn Glu Ala Leu Asp 
    50                  55                  60                  


Lys Lys Ser Arg Leu Tyr Thr Pro Phe Asn Asn Gln Lys Val Ile Ile 
65                  70                  75                  80  


Asp Lys Asn Leu Gln Arg Tyr Ala Asn Asn Leu Lys Arg Cys Tyr Ile 
                85                  90                  95      


Asn Phe Val Lys Gln Tyr Val Asn Asn Lys Ser Phe Asn Tyr Lys Ala 
            100                 105                 110         


Met Gln Phe Ile Pro Asp Ile Gln Asn Pro Lys Thr Asn Asp Ala Val 
        115                 120                 125             


Asn Tyr Arg Thr Asp Arg Asp Asn Val Tyr Asn Lys Asn Lys Tyr Tyr 
    130                 135                 140                 


Asp Lys Gln Thr Lys Ser Lys Ser Lys Lys Phe Ile Tyr Glu Lys Ile 
145                 150                 155                 160 


Val Ile Pro Gln Asn Glu Gln Asn Ile Val Ile Ser Ala Leu Val Asn 
                165                 170                 175     


Cys Ser Leu Arg Lys Ser Leu Arg Lys Asp Val Ser Tyr Lys Thr Lys 
            180                 185                 190         


Ser Gly Glu Ile Lys Thr Tyr Asn Leu Pro Glu Leu Val Lys Lys Ser 
        195                 200                 205             


Met Arg Phe Tyr Cys Leu Glu Gly Gln Arg Glu Pro Asp Glu Lys Glu 
    210                 215                 220                 


Lys Tyr Glu Met Tyr Ile Leu Phe Ser Tyr Met Lys Glu Asp Lys Arg 
225                 230                 235                 240 


Thr Lys Asn Thr Asp Leu Leu Val Lys Ser Ile Ser Asn Gln Asn Thr 
                245                 250                 255     


Lys Val Lys Val Glu Asp Ile Asp Gly Asn Lys Leu Leu Lys Leu Ser 
            260                 265                 270         


Ile Ala Asp Thr Lys Lys Lys Pro Leu Trp Glu Tyr Leu Ile Lys Tyr 
        275                 280                 285             


Ala Asp Ser Ser Arg Gln Arg Glu Leu Met Tyr Asp Ile Arg Lys Lys 
    290                 295                 300                 


Ile Ile Leu Tyr Val Ala Gly Ile Glu Glu Tyr Glu Asn Ile Lys Glu 
305                 310                 315                 320 


Asp Ser Gly Leu Ser Lys Val Ser Trp Ser Lys Tyr Asn Ile Ser Asp 
                325                 330                 335     


Asn Lys Met Phe Phe Asp Ile Asn Ser Cys Thr Asp Lys Arg Lys Gln 
            340                 345                 350         


Asn Leu Glu Ile Lys Ile Arg Glu Ala Asn Ile Glu His Tyr Arg Asn 
        355                 360                 365             


Ala Ser Ser Lys Leu Cys Asp Asp Glu Ser Ile Phe Trp Phe Gln His 
    370                 375                 380                 


Phe Glu Gly Val Ile Glu Thr Leu Phe Ser Lys Lys Ser Lys Ile Ser 
385                 390                 395                 400 


Glu Glu Arg Leu Gly Cys Ala Tyr Ile Cys Asp Tyr Leu Trp Lys Asp 
                405                 410                 415     


Phe Leu Ser Tyr Leu Ala Ala Lys Tyr Ile Asp Leu Gly Lys Gly Val 
            420                 425                 430         


Tyr His Phe Thr Met Lys Asp Lys Leu Asp Met Leu Asn Lys Asn Glu 
        435                 440                 445             


Ala Val Thr Asp Leu Arg Phe Gly Ile Val Ser Glu Lys Tyr Glu Lys 
    450                 455                 460                 


Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Glu Leu 
465                 470                 475                 480 


Asp Arg Asn Ile Ala Ala Tyr Val Thr Phe Ala Ala Asp Ile Phe Ala 
                485                 490                 495     


Lys Ser Val Ile Lys Ser Asp Tyr Arg Thr Lys Lys Asp Asn Asn Ser 
            500                 505                 510         


Asp Val Leu Gln Tyr Ser Asp Lys Glu Phe Arg Asn Ser Glu Val Ile 
        515                 520                 525             


Arg Asp Asn Ala Glu Lys Asn Ile Leu Gln Tyr Trp Gly Gly Tyr Ser 
    530                 535                 540                 


Arg Trp Cys Thr Glu Asn Ser Lys Leu Pro Glu Asn Asn Lys Val Ser 
545                 550                 555                 560 


Asp Phe Gly Lys Leu Asp Val Ser Asp Leu Cys Ile Asp Ile Lys Lys 
                565                 570                 575     


His Leu Ala Gly Ile Arg Asn Ser Ser Val His Tyr Thr Thr Lys Ile 
            580                 585                 590         


Lys Asn Glu Ser Ala Ala Asp Gly Ser Asn Val Lys Ile Leu Phe Glu 
        595                 600                 605             


Lys Asp Leu Ala Asp Ile Asn Ile Ile Tyr Ala Asp Lys Tyr Tyr Ser 
    610                 615                 620                 


Asn Asn Val Trp Met Phe Tyr Ser Leu Glu Asp Ile Asn Lys Leu Ile 
625                 630                 635                 640 


Ala Phe Leu Tyr Lys Glu Lys Arg Val Ile Arg Gln Val Gln Ile Pro 
                645                 650                 655     


Ser Phe Ser Arg Ile Leu Lys Arg Lys Ala Met Gln Asp Val Ile Asn 
            660                 665                 670         


Glu Ile Phe Lys Asp Asp Phe Asp Glu Asn Ile Val Asn Pro Glu Leu 
        675                 680                 685             


Lys Glu Lys Tyr Arg Asn Ser Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
    690                 695                 700                 


Tyr Asn Ala Phe Ile Ile Gln Pro Glu Leu Lys Glu Lys Phe Lys Asp 
705                 710                 715                 720 


Lys Ile Lys Thr Met Lys Ser Glu Leu Tyr Asn Lys Leu Lys Thr Ile 
                725                 730                 735     


Asp Lys Lys Glu Tyr Lys Ala Leu Tyr Cys Met Leu Ser Asn Glu Glu 
            740                 745                 750         


Ser Ala Leu Lys Asn Phe Ala Asp Arg Ile Tyr Ser Val Asp Gly Asp 
        755                 760                 765             


Asn Val Ser Phe Ala Asp Ile Cys Lys Ile Leu Met Thr Asp Tyr Asn 
    770                 775                 780                 


Met Gln Asn Gln Glu Lys Lys Asn Ile Glu Ser Met Glu Gln Lys Lys 
785                 790                 795                 800 


Lys Asn Lys Gly Lys Asp Glu Asn Tyr Lys His Phe Pro Leu Leu Leu 
                805                 810                 815     


His Lys Val Leu Lys Glu Leu Phe Ile Glu Tyr Leu Lys Gln Thr His 
            820                 825                 830         


Glu Leu Glu Phe Leu Arg Asn Asn Ile Cys Ile Lys Ser Asp Val Thr 
        835                 840                 845             


Met Glu Ser Phe Glu Ser Gln Ile Lys Gly Val Glu Ile Tyr Lys Asp 
    850                 855                 860                 


Leu Lys Glu Lys Ile Asp Lys Asn Asn Ser Leu Leu Asp Trp Tyr Val 
865                 870                 875                 880 


Ile Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asn 
                885                 890                 895     


Ile Lys Asn Tyr Ile Gln Phe Ala Thr Asn Ile Asp Lys Arg Ala Glu 
            900                 905                 910         


Ser Val Lys Asn Leu Thr Glu Ser Gly Met Val Lys Arg Ile Gln Tyr 
        915                 920                 925             


Tyr Asp Asp Ile Val Arg Thr Leu Glu Phe Ser Ala Gln Tyr Ile Gly 
    930                 935                 940                 


Lys Ile Ser Asn Asn Ile Asn Asp Tyr Phe Asn Ser Glu Asp Glu Tyr 
945                 950                 955                 960 


Val Ser Phe Leu Ser Lys Tyr Val Gly Phe Ile Asn Asp Lys Ser Glu 
                965                 970                 975     


Asp Val Leu Thr Glu Leu Lys Asp Phe Cys Arg Glu Lys Ile Asn Asn 
            980                 985                 990         


Gly Ser Gln Ile Ile Gly Ile Tyr  Tyr Gly Gly Asp Asn  Val Ile Ile 
        995                 1000                 1005             


Asn Arg  Asn Val Ile Tyr Ala  Gln Met Tyr Ser Asn  Ala Glu Val 
    1010                 1015                 1020             


Phe Ser  Asn Ile Tyr Lys Lys  Val Thr Lys Asn Asp  Ile Ile Asn 
    1025                 1030                 1035             


Tyr Tyr  Glu Lys Gln Asn Asp  Leu Lys Asp Val Phe  Lys Ser Gly 
    1040                 1045                 1050             


Val Cys  Gln Asn Glu Asp Glu  Gln Arg Ser Leu Cys  Glu Phe Gln 
    1055                 1060                 1065             


Gln Leu  Lys Asn Arg Ile Glu  Leu Thr Glu Leu Ser  Thr Tyr Ala 
    1070                 1075                 1080             


Asp Met  Val Asn Asp Phe Met  Ala Gln Phe Val Glu  Trp Ala Tyr 
    1085                 1090                 1095             


Leu Arg  Glu Arg Asp Leu Met  Tyr Phe Gln Leu Gly  Ile His Tyr 
    1100                 1105                 1110             


Ile Arg  Leu Phe Tyr Ser Asp  Asn Val Leu Asp Glu  Lys Tyr His 
    1115                 1120                 1125             


Lys Leu  Ser Asp Asn Val Ile  Asp Ile Glu Glu Gly  Ala Leu Leu 
    1130                 1135                 1140             


Tyr Gln  Ile Val Ala Met Tyr  Asp Tyr Glu Leu Arg  Ile Phe Glu 
    1145                 1150                 1155             


Thr Asp  Asn Ser Gly Asn Ala  Lys Arg Ile Gly Gln  Gly Gly Pro 
    1160                 1165                 1170             


Gly Lys  Ser Ile Pro Val Phe  Leu Lys Lys Tyr Cys  Ser Gly Thr 
    1175                 1180                 1185             


Asp Val  Tyr Glu Cys Gly Leu  Glu Leu Phe Glu Asp  Ile Asn Gln 
    1190                 1195                 1200             


His Glu  His Ile Ile Arg Phe  Arg Asn Asp Ile Ala  His Met Arg 
    1205                 1210                 1215             


Tyr Met  Ser Asn Gln Ala Met  Asn Ile Met Ser Ile  Val Ser Asn 
    1220                 1225                 1230             


Ile Tyr  Lys Ser Phe Phe Ala  Tyr Asp Thr Lys Leu  Lys Lys Ser 
    1235                 1240                 1245             


Ile Ser  Leu Val Phe Lys Asn  Ile Leu Met Arg Tyr  Gly Val Ile 
    1250                 1255                 1260             


Ala Asp  Leu Val Phe Ser Tyr  Asn Asn Lys Asn Gln  Ser Ile Lys 
    1265                 1270                 1275             


Asp Asp  Met Asp Ile Asn Ile  Ile Asn Ile Lys Asn  Leu Lys Ser 
    1280                 1285                 1290             


Asp Lys  Tyr Val Tyr Lys Ile  Val Asn Glu Asp Ile  Val Lys Gln 
    1295                 1300                 1305             


Val Glu  Ile Glu Ile Arg Asn  Gln Val Phe Leu Glu  Gln Leu His 
    1310                 1315                 1320             


Asn Leu  Leu Tyr Phe Ser Arg  
    1325                 1330 


<210>  131
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  131

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Asp Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Thr 
        115                 120                 125             


Lys Asp Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His 
            180                 185                 190         


Glu Arg Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Glu Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Arg 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Lys 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Thr Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Phe Asp Phe Lys Leu  Leu Asn 
    1370                 1375                 1380         


<210>  132
<211>  1101
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  132

Met Arg Ile Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Ile Tyr Ser Glu 
            20                  25                  30          


Gln Ala Val Ser Asn Glu Thr Asn Asn Ile Leu Pro Val Lys Lys Met 
        35                  40                  45              


Asp Ser Phe Asn Leu Ser Ile Leu Asn Lys Thr Ile Ile Lys Phe Glu 
    50                  55                  60                  


Thr Val Lys Lys Gln Lys Leu Asn Leu Asp Gln Tyr Lys Ile Val Glu 
65                  70                  75                  80  


Lys Ile Phe Lys Tyr Pro Lys Gln Glu Leu Pro Lys Gln Ile Asn Ala 
                85                  90                  95      


Glu Glu Ile Leu Gln Phe Leu Asn His Lys Phe Gln Glu Pro Val Lys 
            100                 105                 110         


Tyr Trp Lys Asn Gly Lys Glu Glu Ser Phe Asn Leu Thr Leu Leu Ile 
        115                 120                 125             


Val Glu Ala Val Lys Thr Gln Glu Lys Arg Lys Leu Gln Pro Tyr Tyr 
    130                 135                 140                 


Asp Trp Lys Thr Trp Tyr Ile Gln Thr Lys Ser Asp Leu Leu Lys Lys 
145                 150                 155                 160 


Ser Ile Glu Asn Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg 
                165                 170                 175     


Lys Lys Ala Leu Leu Ala Trp Glu Thr Glu Phe Thr Thr Ser Gly Ser 
            180                 185                 190         


Ile Asp Leu Thr His Phe His Lys Val Tyr Met Thr Asp Val Leu Cys 
        195                 200                 205             


Thr Ala Leu Gln Lys Val Glu Pro Ser Ala Asp Glu Arg Gly Lys Met 
    210                 215                 220                 


Asn Ser Asn Ala Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Asn His 
225                 230                 235                 240 


Gln Pro Ala Ile Phe Gly Thr Arg Glu Ala Pro Asn Glu Val Asn Arg 
                245                 250                 255     


Ala Asp Asn Gln Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu 
            260                 265                 270         


Glu His Tyr Phe Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Ala Asp 
        275                 280                 285             


Asp Ile Ser His Tyr Leu Lys Ala Gln Thr Leu Lys Thr Thr Ile Glu 
    290                 295                 300                 


Lys Gln Leu Val Asn Ala Ile Arg Ala Asn Ile Ile Gln Gln Gly Lys 
305                 310                 315                 320 


Thr Asn His His Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile 
                325                 330                 335     


Arg Ile Lys Thr Asn Glu Ala Phe Val Leu Asn Leu Ile Gly Thr Cys 
            340                 345                 350         


Ala Phe Ala Ala Asn Asn Ile Arg Asn Met Val Asp Lys Glu Gln Ile 
        355                 360                 365             


Ser Asp Ile Leu Gly Lys Arg Glu Phe Ile Asp Ser Leu Thr Lys Ser 
    370                 375                 380                 


Arg Ile Ser Ser Gln Leu Tyr Ser Phe Phe Phe Gly Glu Asn Leu Ser 
385                 390                 395                 400 


Thr Asn Lys Ala Glu Lys Glu Thr Gln Leu Trp Gly Ile Arg Gly Ala 
                405                 410                 415     


Val Gln Gln Ile Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu 
            420                 425                 430         


Thr Thr Ile Phe Asn Ile Cys Lys Phe Glu Asn Pro Thr Asp Ala Asp 
        435                 440                 445             


Pro Lys Gln Gln Thr Asn Tyr Val Asp Ser Ile Tyr Lys Thr Leu Phe 
    450                 455                 460                 


Ile Lys Glu Leu Glu Lys Ile Pro Glu Ala Phe Ala Gln Gln Leu Lys 
465                 470                 475                 480 


Thr Gly Gly Ala Leu Ser Tyr Tyr Thr Val Glu Asn Leu Lys Thr Leu 
                485                 490                 495     


Leu Thr Thr Phe Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala 
            500                 505                 510         


Pro Gly Phe Lys Lys Val Leu Asn Gly Gly Ile Asn Tyr Gln Asn Ala 
        515                 520                 525             


Lys Gln Asp Glu Ser Phe Tyr Glu Leu Met Leu Glu Arg Tyr Leu Arg 
    530                 535                 540                 


Lys Glu Asn Phe Ala Glu Glu Ala Tyr Asn Ala Arg Tyr Phe Leu Leu 
545                 550                 555                 560 


Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Lys Phe Thr Ala Asp Arg 
                565                 570                 575     


Lys Ala Phe Ala Asp Ser Val Gly Phe Val Gln Leu Gln Asn Arg Lys 
            580                 585                 590         


Gln Ala Glu Asn Ser Lys Arg Pro Lys Ala Phe Ala Phe Glu Ala Val 
        595                 600                 605             


Arg Pro Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala Tyr Val 
    610                 615                 620                 


Gln Ser Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys Ala Thr 
625                 630                 635                 640 


Asp Glu Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val Phe Ile 
                645                 650                 655     


Lys Gly Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe Val Gln 
            660                 665                 670         


Val Pro Gln Pro Gln Leu Thr Thr Thr Asp Ser Asn Gln Gln Lys Ala 
        675                 680                 685             


Asp Lys Leu Asn Gln Leu Glu Ala Ser Ile Thr Ala Asp Cys Lys Leu 
    690                 695                 700                 


Thr Ala Gln Tyr Ala Lys Thr Asp Asp Ala Thr His Ile Ala Phe Tyr 
705                 710                 715                 720 


Val Phe Cys Lys Leu Leu Asp Ala Gly His Leu Ser Asn Leu Arg Asn 
                725                 730                 735     


Glu Leu Ile Lys Phe Arg Gly Ser Val Lys Asp Phe Asp Phe His His 
            740                 745                 750         


Leu Leu Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val Val Pro 
        755                 760                 765             


Thr Asp Tyr Arg Asp Leu Tyr Ser Ser Gly Ala Asp Cys Leu Ala Arg 
    770                 775                 780                 


Leu Arg Pro Phe Ile Glu Gln Gly Ala Asp Ile Lys Asn Trp Ser Asp 
785                 790                 795                 800 


Leu Tyr Val Gln Thr Asp Lys Gln Thr Pro Val Ile His Ala Gly Ile 
                805                 810                 815     


Glu Leu Ser Val Lys Tyr Gly Thr Thr Ala Leu Leu Glu Gln Leu Ile 
            820                 825                 830         


Thr Cys Asn Pro Lys Phe Arg Val Met Glu Asp Asn Phe Thr Lys Trp 
        835                 840                 845             


Ser Ala Gln Lys Lys Glu Ile Glu Glu Lys Val Asn Lys His Thr Asn 
    850                 855                 860                 


Leu His Gln Gln Trp Val Glu Ala Lys Glu Lys Asp Asp Arg Glu Arg 
865                 870                 875                 880 


Val Lys Ser Lys Lys Asn Phe Val Arg Glu Tyr Val Lys Lys Asn Tyr 
                885                 890                 895     


Val Asp Tyr Ile Asn Asn Cys Ile Glu Ile Asn Asn Tyr Asn Trp Leu 
            900                 905                 910         


Asp Asn Lys Leu His Phe Val His Leu Asn His Leu His His Leu Thr 
        915                 920                 925             


Ile Asp Ile Leu Gly Arg Met Ala Gly Phe Val Ala Leu Trp Glu Arg 
    930                 935                 940                 


Asp Phe Gln Tyr Ile Thr Lys Tyr Thr Ala Ala Lys Glu Gly Thr Asp 
945                 950                 955                 960 


Ala Leu Ser Phe Asp Gly Gly Leu Pro Arg Leu Lys Asp Lys Gln Glu 
                965                 970                 975     


Tyr Tyr Asn Lys Leu Phe Leu Ser Asp Lys Tyr Thr Lys Val Arg Asn 
            980                 985                 990         


His Ile Ala His Phe Asn Tyr Leu  Thr Lys Asp Ala Ala  Asp Phe Ala 
        995                 1000                 1005             


Leu Leu  Asp Leu Ile Asn Glu  Leu Arg Glu Leu Leu  His Tyr Gly 
    1010                 1015                 1020             


Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ala Phe Ile  Asp Leu Phe 
    1025                 1030                 1035             


Glu Lys  His Gly Met Ile Leu  Lys Leu Lys Leu Asn  Thr Asp His 
    1040                 1045                 1050             


Gln Leu  Val Val Glu Ser Ile  Glu Pro Lys Lys Ile  Tyr His Leu 
    1055                 1060                 1065             


Gly Ser  Thr Ala Lys Asp Lys  Pro Glu Tyr Gln Tyr  Thr Thr Asn 
    1070                 1075                 1080             


Gln Val  Met Thr Val Tyr Cys  Asn Met Cys Arg Ser  Leu Leu Glu 
    1085                 1090                 1095             


Met Lys  Lys 
    1100     


<210>  133
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  133

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Ile Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Phe Asp Phe Lys Leu  Leu Asn 
    1400                 1405                 1410         


<210>  134
<211>  1116
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  134

Met Gly Asn Leu Phe Gly Tyr Lys Lys Trp Tyr Lys Val Asp Lys Ile 
1               5                   10                  15      


Ile Lys Gly Lys Glu Val Lys Val Glu Val Arg Ile Lys Arg Lys Tyr 
            20                  25                  30          


Leu Asp Asn Glu Ser Lys Tyr Val Leu Asn Ile Asn Lys Gln Lys Glu 
        35                  40                  45              


Glu Tyr Asp Glu Asn Lys Ile Thr Asp Lys Glu Phe Ile Asp Gln Phe 
    50                  55                  60                  


Ile Glu Tyr Lys Thr Asn Asn Asp Ile Phe Glu Lys Phe Lys Arg Lys 
65                  70                  75                  80  


Phe His Met Gly Asn Ile Leu Phe Lys Leu Lys Ala Lys Glu Leu Thr 
                85                  90                  95      


Glu Lys Thr Ile Lys Glu Ile Arg Asn Tyr Asn Asp Phe Leu Glu Lys 
            100                 105                 110         


Glu Lys Ala Ile Leu Glu Ile Glu Ile Tyr Gln Gln Ser Glu Lys Leu 
        115                 120                 125             


Ile Glu Glu Glu Asn Ile Thr Lys Lys Asp Ile Ile Asp Lys Ala Ile 
    130                 135                 140                 


Lys Glu Lys Ile Thr Glu Asp Ser Asn Glu Ile Lys Met Gln Ile Lys 
145                 150                 155                 160 


Ser Lys Glu Asn Lys Ser Lys Glu Ile Lys Ile Ser Ile Asn Lys Glu 
                165                 170                 175     


Thr Glu Glu Tyr His Ile Lys Leu Lys Ser Ile Asn Asn Asp Glu Leu 
            180                 185                 190         


Asn Leu Lys Arg Glu Ile Tyr Glu Ile Leu Lys Ser Ile Asn Ala Asn 
        195                 200                 205             


Leu Tyr Thr Ile Thr Lys Asn Thr Ile Ser Asn Ala Asp Phe Lys Lys 
    210                 215                 220                 


Lys Asn Tyr Glu Asn Phe Leu Arg Glu Asn Ile Met Glu His Leu Lys 
225                 230                 235                 240 


Lys Asn Ile Lys Glu Lys Ser Lys Met Thr Phe Phe Lys Ser Leu Ser 
                245                 250                 255     


Asn Ser Leu Lys Lys Ile Gln Gly Asn Ile Lys Glu Asn Asp Glu Ile 
            260                 265                 270         


Ile Asn Phe Ile Lys Tyr Tyr Ser Asn Ile Asn Gly Ser Lys Thr Val 
        275                 280                 285             


Ser Glu Asn Lys Lys Asn Phe Leu Glu Lys Ile Leu Asn Thr Glu Val 
    290                 295                 300                 


Ser Val Ser Glu Asn Asp Ile Ile Asp Phe Ile Ile Gly Glu Leu Lys 
305                 310                 315                 320 


Phe Tyr Gly Ile Ile Lys Arg Ile Glu Lys Leu Gln Lys Glu Gly Lys 
                325                 330                 335     


Arg Thr Glu Thr Glu Ile Lys Asn Thr Tyr Thr Lys Ser Tyr Val Leu 
            340                 345                 350         


Leu Asp Lys His Glu Lys Phe Lys Lys Tyr Asp Arg Asn Ser Lys Asn 
        355                 360                 365             


Glu Ile Val Lys Leu Phe Val Lys Asp Ile Lys Asp Asn Ala Met Ile 
    370                 375                 380                 


Glu Lys Ile Asn Tyr Ile Leu Ser Lys Phe Lys Ile Glu Glu Leu Ile 
385                 390                 395                 400 


Glu Lys Leu Lys Glu Asn Thr Glu Asn Lys Asn Phe Asp Thr Glu Ile 
                405                 410                 415     


Phe Gly Ile Phe Lys Thr His Tyr Gln Asn Ile Phe Ser Ser Glu Lys 
            420                 425                 430         


Phe Glu Asn Lys Ser Asp Glu Glu Lys Glu Leu Tyr Lys Ile Ile Tyr 
        435                 440                 445             


Arg Tyr Leu Lys Gly Arg Ile Glu Lys Ile Leu Val Asn Glu Gln Lys 
    450                 455                 460                 


Val Arg Leu Lys Lys Met Glu Lys Ile Glu Ile Glu Lys Ile Leu Asn 
465                 470                 475                 480 


Glu Ser Ile Leu Ser Glu Lys Ile Leu Lys Arg Val Lys Gln Tyr Thr 
                485                 490                 495     


Leu Glu Tyr Ile Met Tyr Leu Gly Lys Leu Ile His Asn Lys Ile Asn 
            500                 505                 510         


Met Thr Thr Val Asn Thr Asn Asp Phe Ser Arg Leu His Ala Lys Glu 
        515                 520                 525             


Glu Leu Asp Leu Glu Leu Ile Thr Phe Phe Ala Ser Thr Asn Met Glu 
    530                 535                 540                 


Leu Asn Lys Ile Phe Ser Arg Glu Asn Ile Asn Asn Asp Glu Asn Ile 
545                 550                 555                 560 


Asp Phe Phe Gly Gly Asp Arg Glu Lys Asn Tyr Val Leu Asp Lys Lys 
                565                 570                 575     


Asn Leu Asn Ser Lys Ile Glu Ile Ile Arg Asp Leu Asp Phe Ile Asn 
            580                 585                 590         


Asn Lys Asn Asn Ile Thr Asn Asn Phe Ile Ser Lys Phe Thr Lys Ile 
        595                 600                 605             


Gly Thr Asn Glu Arg Asn Arg Ile Leu His Ala Ser Ser Lys Glu Arg 
    610                 615                 620                 


Asp Leu Gln Gly Thr Gln Asp Asp Tyr Asn Lys Val Ile Asn Ile Ile 
625                 630                 635                 640 


Gln Asn Leu Lys Ile Ser Asp Glu Glu Val Ser Lys Ala Leu Asn Leu 
                645                 650                 655     


Asp Val Val Phe Lys Asp Lys Lys Asn Ile Ile Thr Glu Ile Asn Asp 
            660                 665                 670         


Ile Glu Ile Ser Glu Glu Asn Asn Ser Val Ile Lys Tyr Leu Pro Ser 
        675                 680                 685             


Phe Ser Lys Val Leu Pro Glu Ile Leu Asn Leu Tyr Lys Asn Lys Asn 
    690                 695                 700                 


Lys Asn Asn Pro Phe Asp Thr Thr Glu Thr Glu Arg Ile Met Leu Asn 
705                 710                 715                 720 


Ala Leu Ile Tyr Val Asn Lys Glu Leu Tyr Lys Lys Leu Ile Leu Glu 
                725                 730                 735     


Asp Asp Leu Glu Glu Asn Gly Ser Lys Asn Ile Phe Leu Gln Glu Leu 
            740                 745                 750         


Lys Lys Thr Leu Gly Asn Ile Asp Glu Thr Asp Glu Asn Ile Ile Glu 
        755                 760                 765             


Ser Tyr Tyr Lys Asn Ala Gln Ile Ser Ala Ser Lys Gly Asn Asn Lys 
    770                 775                 780                 


Ala Ile Lys Lys Tyr Gln Lys Lys Val Ile Glu Cys Tyr Ile Lys Tyr 
785                 790                 795                 800 


Leu Glu Glu Asn Tyr Lys Lys Leu Phe Asp Phe Ser Asp Phe Lys Met 
                805                 810                 815     


Asn Ile Gln Glu Ile Lys Lys Gln Ile Lys Asp Ile Asn Asp Asn Lys 
            820                 825                 830         


Thr Tyr Glu Arg Ile Thr Ile Lys Thr Ser Asp Lys Ser Ile Val Ile 
        835                 840                 845             


Asn Asp Asp Phe Glu Tyr Ile Ile Ser Ile Phe Ala Leu Leu Asn Ser 
    850                 855                 860                 


Asn Ala Val Ile Asn Lys Ile Arg Asn Arg Phe Phe Ala Thr Ser Val 
865                 870                 875                 880 


Trp Leu Asp Thr Ser Glu Tyr Gln Asn Ile Ile Asn Ile Leu Asp Glu 
                885                 890                 895     


Ile Met Gln Leu Asn Thr Leu Arg Asn Glu Cys Ile Thr Glu Asn Trp 
            900                 905                 910         


Asn Leu Asn Leu Glu Glu Phe Ile Gln Lys Met Lys Glu Ile Glu Lys 
        915                 920                 925             


Asp Phe Asp Asp Phe Lys Ile Gln Thr Lys Lys Asp Ile Phe Asn Gly 
    930                 935                 940                 


Asn Tyr Glu Ser Ile Lys Asn Asn Val Leu Ser Lys Phe Ile Gly Phe 
945                 950                 955                 960 


Ser Asp Val Gln Lys Ile Leu Glu Glu Lys Leu Asn Asn Leu Ile Asp 
                965                 970                 975     


Phe Glu Asn Asp Asn Glu Ile Lys Lys Ser Val Asn Leu Asp Ser Leu 
            980                 985                 990         


Asn Pro Asp Glu Arg Arg Asn Leu  Met Pro Asn Ile Asn  Pro Lys Lys 
        995                 1000                 1005             


Gly Gly  Ile Asp Leu Ile Lys  Glu Ile Asp Lys Leu  Ile Val Ile 
    1010                 1015                 1020             


Lys Lys  Asn Asn Ile Glu Lys  Asn Ile Leu Leu Lys  Ile Ile Phe 
    1025                 1030                 1035             


Asn Ser  Asp Phe Leu Lys Lys  Tyr Lys Lys Glu Ile  Asp Asn Leu 
    1040                 1045                 1050             


Val Glu  Asp Thr Glu Ser Glu  Asn Lys Asn Lys Phe  Glu Lys Ile 
    1055                 1060                 1065             


Tyr Tyr  Pro Glu Glu His Lys  Asn Glu Leu Tyr Ile  Tyr Lys Lys 
    1070                 1075                 1080             


Asn Leu  Phe Leu Asn Ile Gly  Asn Pro Asn Phe Asp  Lys Ile Tyr 
    1085                 1090                 1095             


Glu Leu  Ile Ser Lys Asp Ile  Lys Asn Ala Asn Thr  Glu Ile Leu 
    1100                 1105                 1110             


Phe Asn  Asp 
    1115     


<210>  135
<211>  1257
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  135

Met Arg Gly Gly His Met Lys Ile Thr Lys Ile Asp Gly Ile Ser His 
1               5                   10                  15      


Tyr Lys Glu Lys Glu Lys Gly Val Leu Lys Ala Lys Asp Val Leu Asn 
            20                  25                  30          


Glu Glu Ile Lys Glu Ile Val Lys Lys Arg Tyr Asp Ala Thr Ile Glu 
        35                  40                  45              


Ser Lys Ile Tyr Lys Glu Phe Ile Lys Leu Arg Lys Asn Arg Ile Glu 
    50                  55                  60                  


Gln Asn Asn Glu Lys Ser Val Leu Glu Leu Ile Lys Ser Asn Ile Asp 
65                  70                  75                  80  


Lys Asn Glu Lys Glu Ile Lys Thr Leu Leu Trp Asn Lys Phe Lys Ile 
                85                  90                  95      


Lys Glu Lys Asn Lys Lys Tyr Asp Lys Tyr Ile Leu Asp Glu Ile Lys 
            100                 105                 110         


Leu Asp Asn Asp Ile Lys Ile Tyr Glu Ser Ala Glu Ser Leu Tyr Phe 
        115                 120                 125             


Phe Ile Lys Glu Ala Tyr Leu Gly Gln Asn Asn Lys Lys Trp Asn Ile 
    130                 135                 140                 


Ser Lys Ile Asp Leu Glu Lys Ile Met Glu Lys Asp Asn Asn Leu Ile 
145                 150                 155                 160 


Met Leu Gly Tyr Lys Leu Lys Lys Asn Ile Lys Glu Asp Glu Tyr Pro 
                165                 170                 175     


Tyr Leu Tyr Lys Asn Lys Asn Lys Gln Lys Ser Thr Pro Leu Tyr Thr 
            180                 185                 190         


Leu Leu Lys Lys Leu Ile Glu Lys Asn Lys Asn Ser Asn Gln Asn Ile 
        195                 200                 205             


Arg Glu Ser Glu Glu Tyr Glu Lys Ile Gln Lys Asp Phe Lys Glu Tyr 
    210                 215                 220                 


Lys Asn Ile Lys Ile Asn Leu Leu Val Lys Ser Ile Leu Asn Asn Lys 
225                 230                 235                 240 


Val Asn Ile Lys Tyr Asn Thr Ser Asn Asn Asn Ile Glu Glu Ser Asn 
                245                 250                 255     


Ser Lys Arg Glu Lys Glu Ile Ile Glu Phe Phe Lys Lys Met Ile Glu 
            260                 265                 270         


Glu Lys Asn Lys Ser Ile Leu Lys Asp Lys Leu Lys Leu Phe Arg Leu 
        275                 280                 285             


Glu Val Phe Phe Asp Glu Glu Phe Leu Glu Glu Ile Lys Lys Leu Leu 
    290                 295                 300                 


Asp Asn Asp Asn Leu Asp Lys Ser Asp Asn Lys Lys Ile Ala Glu Leu 
305                 310                 315                 320 


Arg Gly Lys Ile Phe Ser Arg Ile Arg Glu Lys Ile Lys Glu Asp Lys 
                325                 330                 335     


Asn Arg Asp Ile Leu Lys Asn Ile Tyr Phe Leu Glu Leu Lys Lys Tyr 
            340                 345                 350         


Ile Glu Asn Asn Leu Ser His Lys Lys Glu Asn Asn Lys Lys Asn Asn 
        355                 360                 365             


Asn Ile Gly Glu Glu Lys Ser Lys Glu Leu Tyr Leu Lys Phe Leu Lys 
    370                 375                 380                 


Lys Val Leu Phe Ile Asp Asp Asn Asn Arg Ile Ser Ile Glu Lys Leu 
385                 390                 395                 400 


Lys Ser Arg Ile Asp Asp Asn Phe Lys Asn Leu Leu Ile Gln His Val 
                405                 410                 415     


Ile Glu Tyr Gly Lys Ile Lys Tyr Tyr Val Glu Asn Asp Asp Tyr Ile 
            420                 425                 430         


Lys Asn Ile Val Lys Asn Gly Glu Leu Lys Leu Glu Thr Glu Asn Leu 
        435                 440                 445             


Glu Tyr Ile Arg Val Arg Glu Thr Leu Ile Arg Lys Met Ala Val Leu 
    450                 455                 460                 


Val Ser Phe Ala Ala Asn Ser Phe Tyr Asn Leu Phe Glu Asn Ile Thr 
465                 470                 475                 480 


Ser Asp Ile Leu Thr Ala Asn Ile Asn Leu Asp Ser Asp Val Ile Lys 
                485                 490                 495     


Ile Gly Asn Asn Arg Leu Lys Glu Lys Phe Leu Asn Tyr Phe Phe Tyr 
            500                 505                 510         


Ser Glu Glu Ile Ser Asp Lys Glu Asp Phe Leu Lys Ala Leu Lys Asp 
        515                 520                 525             


Ser Ile Tyr Asn Val Arg Asn Gly Val Asn His Phe Asp Lys Met Ile 
    530                 535                 540                 


Leu Gly Lys Tyr Asn Asn Arg Leu Asp Leu Lys Asp Ser Asn Thr Ile 
545                 550                 555                 560 


Lys Asp Tyr Phe Asn Phe Lys Lys Lys Glu Ile Lys Gln Asp Leu Lys 
                565                 570                 575     


Asp Arg Phe Ile Ser Asn Asn Leu Gln Tyr Tyr Tyr Thr Glu Asn Glu 
            580                 585                 590         


Ile Lys Lys Tyr Phe Glu Lys Tyr Lys Phe Glu Ile Leu Lys Thr Lys 
        595                 600                 605             


Ala Ser Phe Ala Pro Asn Phe Lys Arg Ile Leu Arg Lys Gly Glu Asn 
    610                 615                 620                 


Leu Ser Ile Ser Glu Ile Ser Asp Ile Tyr Asp Phe Phe Lys Arg Tyr 
625                 630                 635                 640 


Ser Glu Asn Ser Asp Lys Ser Ser Glu Tyr Asn Glu Phe Thr Lys Thr 
                645                 650                 655     


Arg Asn Phe Leu Leu Lys Glu Leu Tyr Tyr Asn Asn Phe Tyr Arg Glu 
            660                 665                 670         


Phe Leu Ser Asp Arg Thr Lys Phe Glu Glu Ala Val Lys Lys Val Lys 
        675                 680                 685             


Asn Asn Lys Lys Asn Arg Ile Ile Asp Asn Arg Lys Ser Ala Gly Lys 
    690                 695                 700                 


Ser Tyr Asp Val Ile Glu Asp Tyr Asn Ser Ser Asp Asp Val Leu Glu 
705                 710                 715                 720 


Tyr Ile Ser Arg Ile His Lys Ser Glu Met Glu Arg Ile Glu Val Asn 
                725                 730                 735     


Thr Glu Lys Asn Arg Lys Asp Thr Ser Lys Tyr Ile Arg Asp Phe Ile 
            740                 745                 750         


Glu Glu Val Phe Leu Glu Gly Phe Ile Lys Tyr Leu Asp Asn Asn Asn 
        755                 760                 765             


Phe Asn Phe Leu Lys Asn Arg Asn Lys Ala Asp Lys Glu Arg Lys Glu 
    770                 775                 780                 


Ile Val Arg Asn Leu Asn Ile Lys Ile Glu Gly Leu Asp Ile Leu Asn 
785                 790                 795                 800 


Gln Asn Asp Ser Glu Ile Leu Asn Leu Tyr Leu Phe Phe Asn Met Ile 
                805                 810                 815     


Asp Asn Lys Arg Ile Ser Glu Phe Arg Asn Glu Met Ile Lys Tyr Lys 
            820                 825                 830         


Gln Phe Leu Thr Lys Arg Gln Asn Ile Lys Ser Lys Phe Leu Glu Ile 
        835                 840                 845             


Asp Ile Glu Lys Ile Glu Ala Ile Ile Glu Phe Val Ile Ile Thr Arg 
    850                 855                 860                 


Gly Lys Leu Glu Ile Leu Glu Gly Glu Thr Lys Glu Gln Lys Lys Asp 
865                 870                 875                 880 


Asn Met Asn Ala Leu Phe Asn Lys Phe Tyr Ser Ser Glu Ser Glu Tyr 
                885                 890                 895     


Asp Glu Ser Leu Lys Lys Phe Ile Glu Glu Thr Val Leu Asn Asp Lys 
            900                 905                 910         


Lys Asn Thr Pro Phe Tyr Ser Thr Asp Gly Lys Thr Pro Ile Val His 
        915                 920                 925             


Ser Asn Leu Glu Lys Met Arg Lys Tyr Gly Thr Glu Asn Phe Leu Ser 
    930                 935                 940                 


Lys Val Leu Lys Asp Glu Lys Tyr Thr Leu Asp Asn Met Lys Ile Lys 
945                 950                 955                 960 


Glu Lys Phe Glu Thr Lys Val Asn Asp Lys Phe Lys Glu Gln Lys Ile 
                965                 970                 975     


Leu Glu Lys Val Asp Lys Ile Lys Gly Asn Glu Lys His Lys Lys Leu 
            980                 985                 990         


Ile Glu Tyr Tyr Asn Asp Cys Arg  Cys Tyr Leu His Gly  Glu Trp Ile 
        995                 1000                 1005             


Glu Asn  Lys Lys Asn Lys Glu  Glu Phe Glu Tyr Lys  Glu Ile Tyr 
    1010                 1015                 1020             


Glu Lys  Ile Ile Glu Glu Ile  Arg Lys Tyr Asn Tyr  Leu Glu Asn 
    1025                 1030                 1035             


Lys Glu  Lys Leu Gln Asn Val  Tyr Leu Leu His Glu  Ile Thr Ser 
    1040                 1045                 1050             


Asp Leu  Met Ala Arg Asn Val  Ala Phe Ile Asn Lys  Trp Glu Arg 
    1055                 1060                 1065             


Asp Phe  Lys Phe Leu Ser Ile  Ala Ile Lys Glu Asn  Leu Lys Asp 
    1070                 1075                 1080             


Ser Asn  Asp Ile Gln Lys Ile  Glu Glu Phe Leu Asn  Pro Ser Leu 
    1085                 1090                 1095             


Asp Thr  Thr Ser Asp Glu Glu  His Phe Asn Val Lys  Asn Tyr Ala 
    1100                 1105                 1110             


Ser Lys  Leu Lys Asn Ile Gln  Gly Leu His Asn Asn  Ile Ile Ser 
    1115                 1120                 1125             


Leu Ile  Phe Ile Lys Asn Leu  Asp Gly Trp Asn Asn  Lys Ile Asp 
    1130                 1135                 1140             


Asn Phe  Lys Trp Leu Gly Phe  Arg Asn Tyr Ile Ser  His Phe Asn 
    1145                 1150                 1155             


His Ile  Asn Gly Glu Asn Ser  Lys Glu Ser Phe Ile  Asn Gln Leu 
    1160                 1165                 1170             


Asn Arg  Leu Val Leu Leu Phe  Ser Tyr Asp Lys Lys  Val Gln Asn 
    1175                 1180                 1185             


His Ile  Thr Lys Ser Ile Lys  Thr Ile Leu Glu Lys  Tyr Asn Ile 
    1190                 1195                 1200             


Asp Ile  Glu Phe Lys Ile Ser  Asp Asp Ser Lys Asn  Phe Phe Glu 
    1205                 1210                 1215             


Tyr Gln  Ile Ser Asn Ile Asn  Ser Lys Lys Gly Lys  Met Leu Gly 
    1220                 1225                 1230             


Lys Glu  Asn Tyr Phe Glu Leu  Leu Asp Lys Glu Phe  Val Gln Asn 
    1235                 1240                 1245             


Val Lys  Lys Met Leu Glu Tyr  Glu Asp 
    1250                 1255         


<210>  136
<211>  1162
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  136

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Phe Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Glu 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Lys Asp Asp Ile Thr Gly Lys Ile Arg Gly Lys Thr Arg Ile Glu Ser 
                405                 410                 415     


Lys Thr Gly Glu Glu Lys Tyr Ile Pro Gly Glu Val Asp Lys Ile Tyr 
            420                 425                 430         


Asn Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr 
        435                 440                 445             


Ser Tyr Asp Phe Asn Leu Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe 
    450                 455                 460                 


Val Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His 
465                 470                 475                 480 


Phe Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile 
                485                 490                 495     


Ala Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu 
            500                 505                 510         


Lys Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val 
        515                 520                 525             


Phe Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr 
    530                 535                 540                 


Arg Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr 
545                 550                 555                 560 


Lys Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr 
                565                 570                 575     


Trp Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile 
            580                 585                 590         


Asp Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu 
        595                 600                 605             


Asn Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu 
    610                 615                 620                 


Ile Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe 
625                 630                 635                 640 


Tyr Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Lys 
                645                 650                 655     


Tyr Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln 
            660                 665                 670         


Asp Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe 
        675                 680                 685             


Leu Lys Gly Phe Met Thr Tyr Leu Ala Asn Ser Gly Arg Leu Ser Leu 
    690                 695                 700                 


Met Tyr Ile Gly Asn Asp Glu Gln Ile Asn Thr Ser Leu Ala Gly Lys 
705                 710                 715                 720 


Lys Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn 
                725                 730                 735     


Ile Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu 
            740                 745                 750         


Gly Lys Ile Leu Lys Tyr Thr Glu Ser Leu Asn Met Phe Tyr Leu Ile 
        755                 760                 765             


Leu Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu 
    770                 775                 780                 


Glu Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu 
785                 790                 795                 800 


Glu Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp 
                805                 810                 815     


Phe Glu Leu Glu Ala Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly 
            820                 825                 830         


Asn Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Lys Lys 
        835                 840                 845             


Ile Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn 
    850                 855                 860                 


Ile Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys 
865                 870                 875                 880 


Ala Lys Tyr Lys Ile Ser Leu Lys Glu Leu Lys Glu Tyr Asn Asn Lys 
                885                 890                 895     


Lys Asn Glu Ile Glu Lys Asn Ser Thr Met Gln Gln Asn Leu His Arg 
            900                 905                 910         


Lys Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Asn Asp Glu Asp Tyr 
        915                 920                 925             


Lys Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu 
    930                 935                 940                 


Lys Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu 
945                 950                 955                 960 


Leu Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg 
                965                 970                 975     


Asp Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile 
            980                 985                 990         


Glu Glu Ile Phe Asn Phe Asp Asn  Ser Lys Asn Val Lys  Tyr Lys Ser 
        995                 1000                 1005             


Gly Gln  Ile Val Glu Lys Tyr  Ile Asn Phe Tyr Lys  Glu Leu Tyr 
    1010                 1015                 1020             


Lys Asp  Asn Val Glu Lys Arg  Ser Ile Tyr Ser Asp  Lys Lys Val 
    1025                 1030                 1035             


Lys Lys  Leu Lys Gln Glu Lys  Lys Asp Leu Tyr Ile  Arg Asn Tyr 
    1040                 1045                 1050             


Ile Ala  His Phe Asn Tyr Ile  Pro His Ala Glu Ile  Ser Leu Leu 
    1055                 1060                 1065             


Glu Val  Leu Glu Asn Leu Arg  Lys Leu Leu Ser Tyr  Asp Arg Lys 
    1070                 1075                 1080             


Leu Lys  Asn Ala Val Met Lys  Ser Val Met Asn Ile  Leu Lys Glu 
    1085                 1090                 1095             


Tyr Gly  Phe Val Ala Lys Phe  Lys Ile Gly Ala Asp  Lys Lys Ile 
    1100                 1105                 1110             


Glu Ile  Gln Thr Leu Glu Ser  Glu Lys Ile Val His  Leu Lys Asn 
    1115                 1120                 1125             


Leu Lys  Lys Glu Lys Leu Thr  Thr Asn Arg Asn Ser  Lys Glu Leu 
    1130                 1135                 1140             


Cys Lys  Leu Val Lys Val Met  Phe Glu Tyr Lys Met  Glu Glu Lys 
    1145                 1150                 1155             


Lys Ser  Glu Asn 
    1160         


<210>  137
<211>  1317
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  137

Met Cys Cys Glu Val Asp Gln Glu Ala Ala Glu Leu Ala His Glu Gln 
1               5                   10                  15      


Lys Tyr Gln Glu Phe Cys Gln Gln Ile Asp Ser Pro Asp His Glu Ile 
            20                  25                  30          


Gly Pro Ser Asp Phe Val His Leu His Asn His Thr His Tyr Ser Leu 
        35                  40                  45              


Leu Asp Gly Leu Thr Lys Val Pro Asp Leu Ile Asn Tyr Val Lys Gly 
    50                  55                  60                  


Gln Gly Met Glu Ala Val Ala Val Thr Asp His Gly Thr Met Ser Ser 
65                  70                  75                  80  


Leu Ile Glu Leu Tyr Lys Glu Ala Lys Ala Ala Glu Ile Lys Pro Ile 
                85                  90                  95      


Leu Gly Leu Glu Ala Tyr Val Ala Ala Arg Ser Arg Leu Asp Arg Asp 
            100                 105                 110         


Pro Ala Tyr Asp Lys Val Arg Tyr His Ile Thr Leu Leu Ala Met Asn 
        115                 120                 125             


Asp Lys Gly Phe Glu Asn Leu Cys Arg Leu Ala Thr Glu Ala Glu Val 
    130                 135                 140                 


Asn Gly Lys Tyr Tyr Lys Pro Arg Ile Asp His Glu Ile Met Glu Lys 
145                 150                 155                 160 


Tyr Asn Glu Gly Ile Ile Cys Leu Ser Gly Cys Ala Ser Ser Glu Ile 
                165                 170                 175     


Ser Val Arg Leu Lys Asn Gly Asp Met Glu Gly Ala Glu Lys Leu Val 
            180                 185                 190         


Glu Trp Tyr Lys Asn Val Tyr Lys Asp Arg Phe Tyr Leu Glu Met Gln 
        195                 200                 205             


Asp His Gly His Pro Asp Ser Pro Thr His Trp Asp Val Gln Asn Arg 
    210                 215                 220                 


Ile Asn Gln Gly Leu Gln Glu Ile Ala Lys Lys Thr Gly Leu Pro Leu 
225                 230                 235                 240 


Val Val Thr Cys Asp Gly His Tyr Leu Lys His Glu Asp Gln Asp Ala 
                245                 250                 255     


His Glu Ile Leu Leu Cys Ile Gly Thr Ala Ser Asn Leu Ser Asp Pro 
            260                 265                 270         


Asn Arg Met Thr Leu Lys Asp Phe Gln Leu His Val Ile Pro Pro Gln 
        275                 280                 285             


Glu Ile Ile Asp Arg Trp Ser Lys Asp Phe Pro Asp Ala Ile Lys Asn 
    290                 295                 300                 


Thr Arg Lys Ile Ala Glu Arg Cys His Thr Glu Ile Gln Leu Gly Arg 
305                 310                 315                 320 


Ile Leu Ile Pro Lys Phe Pro Ile Pro Asp Gly Asp Ser Glu Lys Ser 
                325                 330                 335     


Tyr Leu Asp Lys Leu Val Phe Arg Gly Leu Ala Phe Arg Tyr Gly Gly 
            340                 345                 350         


Val Thr Gln Glu Glu Ala Ala Lys Leu Ser Ile Glu Glu Cys Arg Lys 
        355                 360                 365             


Leu Leu Ser Glu Lys Ile Leu Glu Arg Ile Asp Tyr Glu Leu Leu Val 
    370                 375                 380                 


Val Asp Lys Met Gly Tyr Asn Gly Tyr Phe Leu Ile Val Gln Asp Phe 
385                 390                 395                 400 


Ile Met Trp Gly Lys Thr Arg Arg Ile Ile Tyr Gly Pro Gly Arg Gly 
                405                 410                 415     


Ser Ala Ala Gly Ser Ile Leu Ala Tyr Ala Leu Arg Ile Thr Glu Leu 
            420                 425                 430         


Asp Pro Met Lys Tyr Asp Leu Leu Phe Glu Arg Phe Leu Asn Pro Asp 
        435                 440                 445             


Arg Ile Ser Met Pro Asp Ile Asp Thr Asp Ile Gln Asp Thr Arg Arg 
    450                 455                 460                 


Asp Glu Val Ile Glu Tyr Cys Thr Asp Lys Tyr Gly Lys Ala Arg Val 
465                 470                 475                 480 


Ala Asn Ile Val Thr Phe Gly Lys Met Met Ala Lys Asn Ala Val Arg 
                485                 490                 495     


Asp Val Ala Arg Val Leu Glu Val Pro Tyr Ala Glu Ala Asp Arg Ile 
            500                 505                 510         


Ala Lys Leu Val Pro Asp Pro Val Gln Gly His His Val Lys Leu Thr 
        515                 520                 525             


Asp Ala Ile Val Asn Thr Pro Asp Leu Lys Tyr Glu Tyr Glu His Asn 
    530                 535                 540                 


Pro Thr Ala Lys Arg Val Ile Asp Tyr Ala Ser Lys Leu Glu Gly Thr 
545                 550                 555                 560 


Ile Arg Ser His Gly Val His Ala Cys Gly Ile Val Ile Ala Pro Asp 
                565                 570                 575     


Asp Leu Val Lys Phe Leu Pro Leu Glu Val Ser Ala Lys Gly Pro Leu 
            580                 585                 590         


Ala Thr Gln Tyr Pro Ser Thr Gln Val Glu Glu Leu Gly Leu Leu Lys 
        595                 600                 605             


Met Asp Phe Leu Gly Leu Ser Asn Leu Ser Val Ile Asn Asn Ala Leu 
    610                 615                 620                 


Arg Met Ile Arg Lys Val Tyr His Asp Asp Ile Asp Leu Tyr Asn Val 
625                 630                 635                 640 


Pro Leu Asp Asp Pro Leu Ala Tyr Gln Leu Leu Gln Asn Ala Glu Thr 
                645                 650                 655     


Thr Gly Val Phe Gln Leu Glu Ser Ala Gly Met Lys Arg Tyr Leu Lys 
            660                 665                 670         


Asp Leu Lys Ala Ser Ser Phe Glu Asp Ile Ile Ala Met Val Ala Leu 
        675                 680                 685             


Tyr Arg Pro Gly Pro Met Gln Phe Ile Asp Ser Phe Ile Arg Arg Lys 
    690                 695                 700                 


His Gly Glu Glu Pro Ile Thr Tyr Leu His Pro Gly Leu Glu Asn Ala 
705                 710                 715                 720 


Leu Lys Ser Thr Tyr Gly Ile Leu Ile Tyr Gln Glu Gln Phe Met Gln 
                725                 730                 735     


Ile Ser Lys Glu Trp Cys Gly Phe Thr Gly Gly Gln Ala Asp Thr Leu 
            740                 745                 750         


Arg Lys Ala Val Gly Lys Lys Lys Val Ala Leu Met Asn Lys Val Lys 
        755                 760                 765             


Pro Glu Phe Ile Lys Gly Ala Gln Glu Val Gly Gly Ala Thr Glu Glu 
    770                 775                 780                 


Gln Ala Glu Thr Phe Trp Asn Gln Leu Leu Glu Phe Ala Asn Tyr Cys 
785                 790                 795                 800 


Phe Asn Lys Ser His Ala Ala Cys Tyr Gly Leu Val Ala Tyr Trp Thr 
                805                 810                 815     


Ala Tyr Leu Lys Ala His Tyr Pro Asp Ala Phe Met Ala Ala Leu Met 
            820                 825                 830         


Thr Ser Asp Met Arg Trp Thr Asp Arg Leu Ala Ile Glu Ile Ala Glu 
        835                 840                 845             


Cys Lys Arg Ile Gly Ile Lys Val Leu Gly Pro Asp Ile Asn Gln Ser 
    850                 855                 860                 


Tyr Ala Asp Phe Gly Ile Val Gly Gly Glu Lys Thr Ile Arg Phe Gly 
865                 870                 875                 880 


Leu Ala Ala Ile Lys Ser Met Gly Lys Ala Leu Ile Glu Glu Ile Val 
                885                 890                 895     


Ile Pro Glu Arg Asp Lys Asn Gly Pro Phe Lys Ser Val Cys Asp Phe 
            900                 905                 910         


Ala Ser Arg Val Asp Asn Thr Lys Phe Asn Lys Lys Ser Trp Glu Ser 
        915                 920                 925             


Ala Ile Lys Thr Gly Ala Phe Asp Arg Phe Ala Ser Arg Thr Asp Leu 
    930                 935                 940                 


Leu Phe Asn Leu Glu Asp Ile Gln Ala Tyr Gly Gly Lys Val Gln Lys 
945                 950                 955                 960 


Asp Arg Ala Ser Gly Gln Thr Asp Leu Phe Gly Leu Met Gly Asp Ala 
                965                 970                 975     


Gly Ala Val Pro Glu Pro Glu Ile Lys Pro Ser Pro Ser Lys Val Ser 
            980                 985                 990         


Glu Lys Glu Gln Leu Leu Trp Glu  Arg Asp Leu Met Gly  Leu Tyr Leu 
        995                 1000                 1005             


Ser Ala  His Pro Leu Asp Lys  Tyr Asp Ile Tyr Phe  Glu Glu Asn 
    1010                 1015                 1020             


Thr His  Pro Phe Ser Val Val  Ser Ala Glu Asn Asp  Gly Lys Gln 
    1025                 1030                 1035             


Val Ile  Val Gly Gly Ile Val  Thr Gly Ile Arg Thr  Ile Leu Thr 
    1040                 1045                 1050             


Lys Ser  Asn Thr Lys Met Ala  Phe Val Lys Ile Glu  Ser Lys Thr 
    1055                 1060                 1065             


Ser Glu  Thr Glu Phe Ile Val  Phe Pro Ala Leu Tyr  Glu Gln Glu 
    1070                 1075                 1080             


Gly Ser  Lys Leu Ala Val Asp  Asn Ile Ile Lys Val  Thr Gly Arg 
    1085                 1090                 1095             


Val Asn  Ala Arg Asp Lys Asp  Gly Asn Ile Thr Ser  Glu Val Lys 
    1100                 1105                 1110             


Ile Ile  Ala Asp Ser Phe Ser  Ile Val Ser Asp Asp  Lys Leu Glu 
    1115                 1120                 1125             


Asn Tyr  Gln Ser Thr Gly Ala  Arg Leu Asp Asp Pro  Lys Glu Ala 
    1130                 1135                 1140             


Pro Lys  Lys Glu Phe Arg Arg  Lys Lys Thr Ala Ser  Val Pro Glu 
    1145                 1150                 1155             


Asn Ile  Ala Ala Arg Leu Ser  Gly Ser Gln Lys Ser  Asp Asp Lys 
    1160                 1165                 1170             


Asn Thr  Glu Lys Lys Glu Ser  Asn Thr Glu Lys Ser  Ala Glu Lys 
    1175                 1180                 1185             


Ala Gly  Lys Thr Asp Lys Glu  Pro Asn Lys Pro Glu  Ser Glu Ser 
    1190                 1195                 1200             


Ile Arg  Asn Tyr Ile Ser His  Phe Tyr Ile Val Arg  Asn Pro Phe 
    1205                 1210                 1215             


Ile Asp  Tyr Ser Ile Ala Glu  Gln Ile Asp Arg Val  Ser Asn Leu 
    1220                 1225                 1230             


Leu Ser  Tyr Ser Thr Arg Tyr  Asn Asn Ser Thr Tyr  Ala Ser Val 
    1235                 1240                 1245             


Phe Glu  Val Phe Lys Lys Asp  Val Asp Leu Glu Tyr  Asp Glu Leu 
    1250                 1255                 1260             


Lys Lys  Lys Phe Lys Leu Ile  Ser Asn Thr Asp Ile  Leu Lys Arg 
    1265                 1270                 1275             


Leu Met  Lys Pro Lys Lys Val  Ser Val Leu Glu Leu  Glu Ser Tyr 
    1280                 1285                 1290             


Asn Ser  Asn Tyr Ile Lys Asn  Leu Ile Ile Glu Leu  Leu Thr Lys 
    1295                 1300                 1305             


Val Glu  Asn Lys Asp Glu Ile  Ser Ser 
    1310                 1315         


<210>  138
<211>  1338
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  138

Met Gly Asn Leu Phe Gly His Lys Arg Trp Tyr Glu Val Glu Lys Ile 
1               5                   10                  15      


Ile Lys Asp Lys Glu Val Lys Val Glu Val Arg Ile Lys Arg Lys Tyr 
            20                  25                  30          


Leu Ala Asn Glu Ser Lys Tyr Val Leu Asn Ile Asp Lys Gln Lys Glu 
        35                  40                  45              


Glu Tyr Asp Glu Asn Lys Ile Thr Asn Lys Glu Phe Val Asp Gln Phe 
    50                  55                  60                  


Ile Glu Tyr Lys Thr Lys Asn Asp Val Phe Lys Lys Phe Thr Lys Lys 
65                  70                  75                  80  


Phe His Met Gly Asn Ile Leu Phe Lys Leu Lys Ala Lys Glu Leu Thr 
                85                  90                  95      


Glu Lys Thr Ile Lys Glu Ile Arg Asn Tyr Asn Asp Phe Leu Glu Lys 
            100                 105                 110         


Glu Lys Ala Ile Leu Glu Ile Glu Ile Tyr Gln Gln Ser Glu Lys Leu 
        115                 120                 125             


Arg Glu Glu Glu Asn Ile Thr Lys Lys Asp Ile Ile Asp Lys Ala Ile 
    130                 135                 140                 


Lys Glu Lys Ile Thr Glu Asp Ser Asn Glu Ile Lys Met Gln Ile Lys 
145                 150                 155                 160 


Ser Lys Glu Asn Lys Ser Lys Glu Ile Lys Ile Ser Ile Asn Lys Glu 
                165                 170                 175     


Thr Glu Glu Tyr His Ile Lys Leu Lys Ser Ile Asn Asn Asp Glu Leu 
            180                 185                 190         


Asn Leu Lys Arg Glu Ile Tyr Glu Ile Leu Lys Ser Ile Asn Ala Asn 
        195                 200                 205             


Leu Tyr Ile Ile Thr Lys Asn Ala Ile Ser Asn Ala Asp Phe Lys Lys 
    210                 215                 220                 


Arg Asn Tyr Glu Asn Phe Leu Arg Glu Asn Ile Met Glu His Leu Lys 
225                 230                 235                 240 


Lys Asn Ile Arg Lys Lys Ser Lys Met Thr Phe Leu Lys Ser Leu Ser 
                245                 250                 255     


Asn Ser Leu Lys Lys Ile Gln Gly Asn Ile Lys Glu Asn Asp Glu Ile 
            260                 265                 270         


Ile Asn Phe Ile Lys Tyr Tyr Ser Asn Ile Asn Gly Ser Lys Thr Val 
        275                 280                 285             


Ser Glu Asn Lys Lys Asn Phe Leu Glu Lys Ile Leu Asn Thr Glu Val 
    290                 295                 300                 


Ser Val Ser Glu Asn Asp Ile Ile Asp Phe Ile Ile Gly Glu Leu Lys 
305                 310                 315                 320 


Phe Tyr Gly Ile Ile Lys Arg Ile Glu Lys Leu Gln Glu Lys Thr Ala 
                325                 330                 335     


Thr Arg Thr Asp Glu Asp Ile Lys Asn Thr Tyr Ile Asp Thr Tyr Val 
            340                 345                 350         


Ser Leu Asp Lys His Glu Lys Phe Lys Lys Tyr Asn Arg Asn Lys Lys 
        355                 360                 365             


Asp Glu Ile Val Lys Leu Phe Val Lys Asp Ile Asn Asn Asn Thr Met 
    370                 375                 380                 


Glu Glu Lys Ile Asn Gln Ile Leu Ser Lys Phe Lys Ile Glu Glu Leu 
385                 390                 395                 400 


Ile Gly Glu Leu Lys Lys Asn Thr Glu Asn Lys Asn Phe Asp Thr Glu 
                405                 410                 415     


Ile Phe Gly Ile Phe Lys Thr His Tyr Gln Lys Ile Phe Ser Ser Glu 
            420                 425                 430         


Lys Phe Glu Asn Lys Ser Asp Glu Glu Lys Glu Leu Tyr Lys Ile Ile 
        435                 440                 445             


Tyr Arg Tyr Leu Lys Gly Arg Ile Glu Lys Ile Leu Ile Asn Gly Glu 
    450                 455                 460                 


Lys Val Arg Leu Lys Lys Met Glu Lys Ile Glu Val Lys Lys Ile Phe 
465                 470                 475                 480 


Asn Glu Ser Ile Leu Ser Glu Lys Ile Leu Lys Arg Val Lys Gln Tyr 
                485                 490                 495     


Thr Leu Glu Tyr Val Met Tyr Leu Gly Lys Leu Val His Asn Asp Ile 
            500                 505                 510         


Asp Arg Ser Ile Val Asn Thr Asn Asn Phe Ser Arg Leu His Ala Arg 
        515                 520                 525             


Glu Glu Leu Asp Leu Glu Leu Ile Thr Phe Phe Ala Ser Thr Asn Met 
    530                 535                 540                 


Glu Leu Asn Lys Ile Phe Ser Arg Lys Asp Glu Tyr Glu Glu Asn Thr 
545                 550                 555                 560 


Asp Phe Phe Gly Glu Gly Ala Phe Ser Asn Lys Lys Arg Glu Lys Ile 
                565                 570                 575     


Thr Leu Asn Lys Lys Ser Leu Asn Ser Lys Ile Lys Met Ile Arg Glu 
            580                 585                 590         


Leu Asp Phe Ile Asp Asn Lys Asn Glu Ile Ile Gln Lys Asn Phe Phe 
        595                 600                 605             


Asp Lys Phe Ile Lys Ile Gly Ala Asn Glu Arg Asn Arg Ile Leu His 
    610                 615                 620                 


Ala Ser Asn Lys Arg Arg Ile Pro Gln Gly Thr Gln Asp Asp Tyr Asn 
625                 630                 635                 640 


Lys Val Ile Asn Ile Ile Gln Asn Leu Lys Ile Ser Asp Glu Glu Ala 
                645                 650                 655     


Ser Lys Ala Leu Asn Leu Asp Val Val Phe Lys Asp Lys Lys Asn Ile 
            660                 665                 670         


Ile Thr Lys Ile Asn Asp Ile Lys Ile Ser Glu Glu Asn Asn Ser Ile 
        675                 680                 685             


Ile Lys Tyr Leu Pro Ser Phe Ser Lys Val Leu Pro Glu Ile Leu Asn 
    690                 695                 700                 


Leu Tyr Lys Asn Glu Asn Lys Asn Asn Pro Phe Asp Thr Ile Glu Thr 
705                 710                 715                 720 


Glu Lys Ile Ile Gln Asn Ala Leu Ile Tyr Val Asn Lys Glu Leu Tyr 
                725                 730                 735     


Lys Lys Leu Ile Ser Glu Lys Asn Leu Glu Glu Asn Glu Ser Lys Asn 
            740                 745                 750         


Lys Phe Leu Lys Glu Leu Lys Lys Asn Leu Ser Gly Thr Asp Glu Thr 
        755                 760                 765             


Asp Glu Asn Ile Ile Glu Asn Tyr Tyr Lys Asn Ala Gln Ile Ser Ala 
    770                 775                 780                 


Ser Lys Gly Asn Asn Lys Ala Ile Lys Lys Tyr Gln Lys Lys Val Ile 
785                 790                 795                 800 


Glu Cys Tyr Ile Gly Tyr Leu Arg Lys Asn Tyr Glu Glu Leu Phe Asp 
                805                 810                 815     


Phe Ser Asp Phe Lys Met Asn Ile Gln Glu Ile Lys Lys Gln Ile Lys 
            820                 825                 830         


Asp Ile Asn Asp Asn Lys Thr Tyr Glu Arg Ile Thr Ile Lys Thr Ile 
        835                 840                 845             


Asp Lys Thr Ile Val Ile Asn Asp Asp Phe Glu Tyr Ile Ile Ser Ile 
    850                 855                 860                 


Phe Ala Leu Leu Asn Ser Asn Ala Val Ile Asn Lys Ile Arg Asn Arg 
865                 870                 875                 880 


Phe Phe Ala Thr Ser Val Trp Leu Asn Thr Ser Glu Tyr Gln Asn Ile 
                885                 890                 895     


Ile Asn Ile Leu Asp Glu Ile Met Gln Leu Asn Thr Leu Arg Asn Glu 
            900                 905                 910         


Cys Ile Thr Glu Asn Trp Asn Leu Asn Leu Glu Glu Phe Ile Gln Lys 
        915                 920                 925             


Met Lys Glu Ile Glu Lys Asp Phe Asp Asp Phe Lys Ile Gln Thr Lys 
    930                 935                 940                 


Lys Asp Ile Phe Asn Asp Asn Tyr Glu Ser Ile Lys Asn Asn Val Leu 
945                 950                 955                 960 


Ser Lys Phe Ile Gly Phe Ser Asp Val Gln Lys Ile Leu Glu Glu Lys 
                965                 970                 975     


Leu Asn Lys Leu Ile Asp Phe Glu Asn Asp Asn Glu Ile Lys Lys Ser 
            980                 985                 990         


Val Asn Ser Asp Ser Leu Asp Ser  Asp Glu Arg Arg Asn  Leu Met Pro 
        995                 1000                 1005             


Asn Ile  Asn Pro Lys Lys Gly  Gly Ile Asp Leu Ile  Arg Glu Ile 
    1010                 1015                 1020             


Asp Glu  Leu Ile Val Ile Glu  Lys Asn Asn Thr Glu  Lys Lys Glu 
    1025                 1030                 1035             


Lys Thr  Val Ala Lys Arg Asp  Lys Ala Glu Thr Lys  Lys Thr Glu 
    1040                 1045                 1050             


Val Val  Lys Thr Glu Ala Ser  Lys Val Lys Ala Ser  Lys Val Lys 
    1055                 1060                 1065             


Glu Ala  Val Ser Arg Glu Pro  Tyr Glu Glu Ser Ala  Gln Asn Pro 
    1070                 1075                 1080             


Glu Leu  Gly Glu Glu Pro Leu  Glu Asn Ala Ser Gln  Asp Asn Val 
    1085                 1090                 1095             


Ser Arg  Asp Glu Val Arg Arg  Glu Gly Pro Arg Asp  Thr Asp Ala 
    1100                 1105                 1110             


Lys Glu  Ala His Gly Ile Leu  Glu Val Met Ala Asp  Gly Tyr Gly 
    1115                 1120                 1125             


Phe Ile  Arg Ser Glu Asn Phe  Met Pro Gly Glu Gln  Asp Val Tyr 
    1130                 1135                 1140             


Val Asn  Ser Leu Met Ile Arg  Arg Phe His Leu Lys  Thr Gly Asp 
    1145                 1150                 1155             


Met Ile  Tyr Gly Tyr Ala Lys  Ser Arg Asn Pro Gln  Glu Arg Tyr 
    1160                 1165                 1170             


Asn Ala  Leu Leu Tyr Ile Glu  Thr Val Asn Asp Leu  Pro Val Ser 
    1175                 1180                 1185             


Ala Ile  Phe Arg Arg Pro Asp  Phe Asp Lys Leu Thr  Pro Ile Phe 
    1190                 1195                 1200             


Pro Asp  Glu Arg Ile His Met  Glu Arg Glu Gly Lys  Arg Val Pro 
    1205                 1210                 1215             


Thr Ser  Leu Arg Val Leu Asp  Leu Leu Ala Pro Ile  Gly Lys Gly 
    1220                 1225                 1230             


Gln Arg  Gly Met Ile Val Ser  Pro Pro Lys Ala Gly  Lys Thr Thr 
    1235                 1240                 1245             


Leu Leu  Lys Gln Ile Ala Gln  Ser Ile Leu Lys Asn  Gln Pro Asp 
    1250                 1255                 1260             


Met Thr  Leu Met Ile Leu Leu  Ile Asp Glu Arg Pro  Glu Glu Val 
    1265                 1270                 1275             


Thr Asp  Met Met Glu Glu Val  Val Gly Asp Lys Val  Gln Val Ile 
    1280                 1285                 1290             


Tyr Ser  Thr Phe Asp Glu Leu  Pro Glu His His Lys  Arg Val Ala 
    1295                 1300                 1305             


Glu Met  Thr Ile Glu Arg Gly  Lys Arg Leu Val Glu  Gln Gly Gln 
    1310                 1315                 1320             


Asp Val  Cys Ile Leu Leu Asp  Ser Ile Thr Arg Leu  Ala Arg Ala 
    1325                 1330                 1335             


<210>  139
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  139

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Thr Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Asn Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Asp Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Ser Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val His Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Leu Asn 
    1400                 1405                 1410         


<210>  140
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  140

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Thr Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Asp Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Ser Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val His Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Leu Asn 
    1400                 1405                 1410         


<210>  141
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  141

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Lys Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn Gln Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Ile Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Asn Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Val Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Phe Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Val Leu Glu 
        355                 360                 365             


Lys Gln Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn Met 
    370                 375                 380                 


Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser Thr 
385                 390                 395                 400 


Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile His 
                405                 410                 415     


His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala Glu 
            420                 425                 430         


Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp Lys 
        435                 440                 445             


Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys Val 
    450                 455                 460                 


Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val Lys 
465                 470                 475                 480 


Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser Phe 
                485                 490                 495     


Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu Ala 
            500                 505                 510         


Val Asn Val Ala Phe Ala Ala Asn Asn Leu Val Arg Ala Val Cys Asp 
        515                 520                 525             


Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn Lys 
    530                 535                 540                 


Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser Val 
545                 550                 555                 560 


Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile Asp 
                565                 570                 575     


Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val Cys 
            580                 585                 590         


Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu Ser 
        595                 600                 605             


Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr Glu 
    610                 615                 620                 


Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp Ile 
625                 630                 635                 640 


Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser Asp 
                645                 650                 655     


Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val Ser 
            660                 665                 670         


Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys Tyr 
        675                 680                 685             


Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly Tyr 
    690                 695                 700                 


Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu Leu 
705                 710                 715                 720 


Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu Ala 
                725                 730                 735     


Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp Gln 
            740                 745                 750         


Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys Ser 
        755                 760                 765             


Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu Tyr 
    770                 775                 780                 


Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp Ser 
785                 790                 795                 800 


Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys Lys 
                805                 810                 815     


Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Lys Glu Leu 
            820                 825                 830         


Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu Ile 
        835                 840                 845             


Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val Ser 
    850                 855                 860                 


Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr Ile 
865                 870                 875                 880 


Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly Ser 
                885                 890                 895     


Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala Asp 
            900                 905                 910         


Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val Val 
        915                 920                 925             


Asp Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser Arg 
    930                 935                 940                 


Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr Ala 
945                 950                 955                 960 


Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro Ser 
                965                 970                 975     


Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp Leu 
            980                 985                 990         


Tyr Val Asp Pro Ser Asn Pro Lys  Val Asn Arg Asn Ile  Val Gln Ser 
        995                 1000                 1005             


Lys Leu  Phe Ala Ala Asp Tyr  Ile Leu Arg Asp Ile  Ile Glu Pro 
    1010                 1015                 1020             


Val Ser  Lys Asp Glu Ile Glu  Asp Phe Tyr Asn Gln  Lys Asp Glu 
    1025                 1030                 1035             


Ile Thr  Thr Cys Lys Ile Lys  Gly Ala Glu Leu Thr  Asp Glu Glu 
    1040                 1045                 1050             


Gln Lys  Lys Ile Leu Lys Tyr  Gln Lys Leu Lys Asn  Arg Val Glu 
    1055                 1060                 1065             


Leu Arg  Asp Val Val Glu Tyr  Gly Glu Ile Ile Asn  Glu Leu Leu 
    1070                 1075                 1080             


Gly Gln  Leu Ile Asn Trp Ser  Phe Met Arg Glu Arg  Asp Leu Leu 
    1085                 1090                 1095             


Tyr Phe  Gln Leu Gly Phe His  Tyr Asn Cys Leu Arg  Asn Asp Ser 
    1100                 1105                 1110             


Ala Lys  Pro Glu Glu Tyr Lys  Asn Leu Val Leu Asp  Asp Val Ser 
    1115                 1120                 1125             


Ile Lys  Asp Ala Ile Leu His  Gln Ile Ile Gly Met  Tyr Val Asn 
    1130                 1135                 1140             


Gly Val  Ala Ile Tyr Ala Pro  Gly Lys Asp Lys Asn  Lys Leu Glu 
    1145                 1150                 1155             


Ser Gln  Cys Val Lys Gly Arg  Val Gly Gly Lys Ile  Gly Ala Phe 
    1160                 1165                 1170             


Cys Gly  Tyr Ser Leu Tyr Leu  Lys Leu Ala Ala Asp  Thr Leu Tyr 
    1175                 1180                 1185             


Asn Ala  Gly Leu Glu Val Phe  Glu Val Leu Pro Glu  His Glu Asp 
    1190                 1195                 1200             


Ile Ile  Asn Leu Arg Asn Gly  Ile Asp His Phe Lys  Phe Tyr Leu 
    1205                 1210                 1215             


Gly Gly  Tyr Arg Ser Ile Ile  Ser Leu Tyr Ser Glu  Val Phe Asp 
    1220                 1225                 1230             


Arg Phe  Phe Thr Tyr Asp Met  Lys Tyr Gln Lys Asn  Val Leu Asn 
    1235                 1240                 1245             


Leu Leu  Gln Asn Ile Leu Leu  Arg His Asn Val Ile  Ile Glu Pro 
    1250                 1255                 1260             


Ile Phe  Glu Ser Gly Ile Lys  Lys Ile Gly Lys Asp  Thr Lys Pro 
    1265                 1270                 1275             


Cys Ala  Lys Leu Cys Ile Ser  Ser Ile Lys Ser Asp  Ser Phe Glu 
    1280                 1285                 1290             


Tyr Lys  Ile Lys Asp Gly Thr  Leu Ile Thr Asp Ala  Lys Asp Lys 
    1295                 1300                 1305             


Arg Tyr  Leu Glu Thr Ile Lys  Lys Leu Leu Tyr Tyr  Pro Asp Ile 
    1310                 1315                 1320             


Glu Ser  Asn Val Lys Ile Leu  Leu Arg Lys Asp Asn  Phe Asn Gln 
    1325                 1330                 1335             


Asn Lys  Asp Lys Lys Asn Val  Asn Asn Arg Lys Thr  Lys Asn Asn 
    1340                 1345                 1350             


Asn Lys  Asn Gly Asn Arg Asn  Arg Asp Lys Asn Arg  Asp Lys Asn 
    1355                 1360                 1365             


Gly Gly  Gly Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Ile 
    1370                 1375                 1380             


Phe Asp  Leu Pro Glu 
    1385             


<210>  142
<211>  1138
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  142

Met Val Asn Glu Asp Ser Asp Ile Trp Phe Glu His Ser Ala Arg Arg 
1               5                   10                  15      


Asn Asp Ser Thr Pro Tyr Cys Glu Ala Val Ile Ile Glu Thr Thr Asp 
            20                  25                  30          


Arg Asn Gly Thr Ile Arg Lys Lys Leu Asp Met Arg Ala Thr Arg Asn 
        35                  40                  45              


Asn Ile Arg Asn Gln Asn Met Met Asp Tyr Arg Arg Thr Thr Glu Thr 
    50                  55                  60                  


Val Ala Asn Asp Thr Glu Gly Arg Phe Phe Glu Asn Ala Asp Val Asn 
65                  70                  75                  80  


Ala Phe Trp Ile His His Ile Glu Asn Ala Ile Glu Arg Ile Thr Ala 
                85                  90                  95      


Asn Ile Asn Ala Asn Lys Thr Tyr Lys Leu Thr Arg Gly Tyr Leu Gly 
            100                 105                 110         


Glu Lys Val Trp Lys Asp Ile Ile Asn Phe Ile Ser Ile Lys Tyr Ile 
        115                 120                 125             


Ala Val Gly Lys Ala Val Tyr His Phe Ala Ala Asp Asp Ile Asn Thr 
    130                 135                 140                 


Asp Ser Lys Glu Ile Asn Ile Gly Lys Ile Ile Ser Glu Lys Lys Gly 
145                 150                 155                 160 


Gly Met Ser Ser Phe Asp Tyr Glu Gln Ile Lys Ala Glu Glu Thr Leu 
                165                 170                 175     


Gln Arg Glu Thr Ala Thr Tyr Val Ala Phe Ala Val Asn Asn Leu Ala 
            180                 185                 190         


Thr Ala Thr Val Asn Leu Ser Glu Lys Arg Glu Asp Ile Leu Leu Leu 
        195                 200                 205             


Gly Glu Asn Ala Leu Gly Lys Glu Cys Lys Pro His Ile Arg Arg Asn 
    210                 215                 220                 


Val Leu Gln Tyr Phe Gly Gly Asn Ser Leu Trp Glu Lys Ser Gly Ser 
225                 230                 235                 240 


Pro Phe Glu Asp Val Ser Glu Asp Asp Thr Ala Asp Ile Arg Leu Leu 
                245                 250                 255     


Val Ala Ile Lys Asn Ala Leu Tyr Ser Leu Arg Asn Tyr Ser Phe His 
            260                 265                 270         


Tyr Asn Thr Ala Asp Glu Asn Asp Ser Glu Ala Cys Ser Glu Leu Ile 
        275                 280                 285             


Ala Lys Met Phe Glu Phe Asp Ser Asn Arg Ala Ser Ser Ile Gln Ile 
    290                 295                 300                 


Glu Lys Leu Tyr Ser Asn Asn Leu Pro Met Phe Tyr Ser Gln Ala Asn 
305                 310                 315                 320 


Leu Glu Lys Leu Val Gly Arg Ile Tyr Ala Glu Tyr Ala Glu Arg Ala 
                325                 330                 335     


Ser Gln Ile Pro Ser Phe Asn Lys Val Phe Val Arg Ser Asn Phe Ala 
            340                 345                 350         


Glu Tyr Leu Arg Asn Asp Leu Arg Ile Asn Val Ala Leu Asn Gly Thr 
        355                 360                 365             


Glu Glu Leu Ser Lys Trp His Ser Ala Val Tyr Tyr Ala Phe Lys Glu 
    370                 375                 380                 


Ile Tyr Tyr Asn Ala Phe Ile Gln Asp Lys Ser Thr Arg Asp Leu Phe 
385                 390                 395                 400 


Ile Lys Lys Val Lys Ser Leu Lys Pro Arg Glu Asp Lys Lys Thr Asp 
                405                 410                 415     


Ser Lys Ala Ile Glu Asn Phe Ala Met Arg Ile Lys Glu Ile Glu Gln 
            420                 425                 430         


Ala Asn Pro Asp Phe Ser Leu Ala Gln Ile Cys Gln Ile Ile Met Thr 
        435                 440                 445             


Glu Gln Asn Leu Gln Asn Gly Gly Asn Ser Lys Ala His Leu Thr Lys 
    450                 455                 460                 


Asp Ala Gly Glu Asn Glu Ala Ile Tyr Lys His Tyr Lys Met Leu Leu 
465                 470                 475                 480 


Tyr Lys Ala Leu Arg Asp Ala Phe Met Glu Tyr Ile Asp Gly Ser Asp 
                485                 490                 495     


Phe Ala Phe Leu Lys Glu Pro His Glu Tyr Arg Glu Val Ser Lys Glu 
            500                 505                 510         


Asp Phe Thr Val Arg Ser Gly Ser Asn Ile Tyr Ser Glu Leu Ser Gly 
        515                 520                 525             


Leu Ile Asn Glu Asp Pro Ser Leu Leu Asn Tyr Tyr Ile Leu Ser Arg 
    530                 535                 540                 


Met Leu Ala Pro Arg Gln Gln Asn Phe Leu Ala Gly Ser Leu Arg Ser 
545                 550                 555                 560 


Tyr Val Gln Tyr Ser Glu Asp Val Glu Arg Arg Ala Lys Gln Thr Arg 
                565                 570                 575     


Asn Ser Leu Ser Lys Asp Ser Ser Ala Asp Arg Ala Tyr Ile Arg Thr 
            580                 585                 590         


Ala Val Arg Ile Ile Asp Met Cys Ile Gln Ile Ser Gly Thr Thr Ser 
        595                 600                 605             


Asn Thr Val Ala Asp Tyr Phe Asp Asn Glu Asp Ser Phe Ala Glu Tyr 
    610                 615                 620                 


Val Phe Lys Tyr Tyr Asp Ile Gly Ser Glu Tyr Glu Asn Val Gly Ile 
625                 630                 635                 640 


Ser Pro Ala Ala Lys Leu Lys Ala Phe Cys Asn Thr Glu Tyr Ala Lys 
                645                 650                 655     


Asp Lys Arg Ile Gly Leu Phe Tyr Asp Gly Glu Asn Pro Ile Leu Asn 
            660                 665                 670         


Arg Asn Leu Ile Leu Ala Lys Leu Tyr Gly Ala Asp Asn Val Ile Ser 
        675                 680                 685             


Lys Ile Val Lys Lys Asn Asn Lys Glu Glu Ile Glu Asp Leu Tyr Arg 
    690                 695                 700                 


Lys Ser Ala Glu Ile Glu Asp Tyr Lys Val Thr Gly Thr Tyr Lys Ser 
705                 710                 715                 720 


Phe Asp Val Leu Lys Lys Ile Lys Ala Tyr Gln Glu Lys Lys Asn Lys 
                725                 730                 735     


Val Glu Leu Arg Asp Val Val Asp Tyr Ser Glu Ile Ile Asn Glu Leu 
            740                 745                 750         


Gln Gly Gln Leu Ile Asn Gly Ser Leu Met Arg Glu Arg Asp Phe Met 
        755                 760                 765             


Tyr Phe Gln Leu Gly Phe His Tyr Tyr Cys Leu His Asn Glu Glu Cys 
    770                 775                 780                 


Ile Lys Ser Asp Asn Tyr Arg Ser Leu Thr Val Gly Asp Lys Thr Ile 
785                 790                 795                 800 


Asn Gly Ala Ile Leu Tyr Gln Ile Ile Ala Met Tyr Thr Tyr Gly Leu 
                805                 810                 815     


Pro Met Tyr Val Ala Asp Glu Asn Gly Ser Ile Lys Ala Val Gly Asp 
            820                 825                 830         


Arg Glu Gln Thr Ala Asn Lys Val Lys Leu Leu Gly Glu Tyr Thr Leu 
        835                 840                 845             


Asn Asp Ser Gly Phe Tyr Ser Thr Ser Asn Ala Gly Tyr Tyr Ala Asp 
    850                 855                 860                 


Ala Gly Tyr Glu Leu Phe Gly Val Leu Glu Glu Gln Gly Asn Val Tyr 
865                 870                 875                 880 


Ser Leu Arg Asn Tyr Ile Asp His Phe His Tyr Tyr Ala Lys Gln Asp 
                885                 890                 895     


Arg Ser Leu Leu Asp Ile Tyr Ser Glu Val Phe Asp Arg Phe Phe Thr 
            900                 905                 910         


Tyr Asp Ile Lys Tyr Gln Lys Asn Val Ile Asn Leu Leu Ser Ser Val 
        915                 920                 925             


Leu Ser Ser His Phe Val Asp Ala Ser Phe Met Leu Glu Ser Asp Pro 
    930                 935                 940                 


Val Lys Asn Leu Lys Lys Gln Ile Gly Lys Asn Gly Asn Lys Thr Lys 
945                 950                 955                 960 


Glu Met Ala Thr Ile Arg Ile Asn Pro Ala Gln Gly Ile Lys Ser Glu 
                965                 970                 975     


Leu Phe Thr Tyr Ser Val Glu Asn Glu Asp Arg Ala Arg Asn Leu Pro 
            980                 985                 990         


Ala Arg Ser Pro Glu Tyr Leu Glu  Asn Val Ala Arg Ile  Leu Cys Tyr 
        995                 1000                 1005             


Pro Asn  Leu Glu Leu Val Thr  Glu Asp Leu Ile Lys  Leu Pro Arg 
    1010                 1015                 1020             


Val Lys  Glu Asp Arg Gly Gly  His Arg Asp Leu Gly  Lys Gln His 
    1025                 1030                 1035             


Gly Asp  Arg Lys Arg Asp Asn  Asn Tyr Asn Glu Tyr  Gln Lys Tyr 
    1040                 1045                 1050             


Lys Lys  Asn Asn Glu Ser Val  Gly Thr Leu Ser Ala  Met Ile Asn 
    1055                 1060                 1065             


Ile His  Thr Asp Ile Asp Leu  Asp Lys Asp Tyr Thr  Cys Glu Val 
    1070                 1075                 1080             


Thr Gln  Ile Asp Lys Lys Ser  Gly Tyr Gly Arg Gly  Lys Leu Pro 
    1085                 1090                 1095             


Asn Gly  Glu Glu Ala Thr Phe  Lys Trp Lys Gly Thr  Ser Ile Val 
    1100                 1105                 1110             


Asn Gly  Ala Thr Ile Thr Val  Arg Leu Lys Lys Tyr  Asp Asp Arg 
    1115                 1120                 1125             


Arg Lys  Ala Tyr Glu Ala Thr  Val Val Gly 
    1130                 1135             


<210>  143
<211>  1380
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  143

Met Lys Leu Ser Lys Glu Lys Gln Ile Arg Ser Ala Val Ala Asn Lys 
1               5                   10                  15      


Glu Lys Asn Thr Glu Gly Val Leu Tyr Arg Phe Pro Gly Asp Asp Ile 
            20                  25                  30          


Gly Gly Val Gln Ala Gln Met Leu Val Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Leu Gly Asn Lys Pro Lys Glu 
    50                  55                  60                  


Trp Met Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Lys Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Ala Ile Asn Asp Ile Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Lys Glu Ala Asp Lys Lys Ile Arg Asn Met Ser Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Asn Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Ser Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Gly Asn Gln Glu Phe Asp Ser Ile Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Asp Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Ser Ile Gln Asp Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Ile Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Glu Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Asp Gly Leu Asn Glu Phe Met Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Glu Glu Lys Arg Ala Glu Val Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Ser His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Val Asn Lys Gly Lys Phe Tyr Val Trp 
305                 310                 315                 320 


Lys Lys His Glu Cys Gly Lys Lys Glu Asn Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Val Glu Ala Glu Ala Glu Ser Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Ile Phe Phe Glu Asn Asp Thr Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Thr Gly Thr Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Lys Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asn Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Gln Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Leu 
            660                 665                 670         


Val Arg Thr Val Phe Pro Glu Tyr Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Asn Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Arg Thr Leu Arg Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Lys 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Glu Asn Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Cys Ala Gln Asp 
            900                 905                 910         


Ile Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu 
        915                 920                 925             


Leu Ser Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Lys Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Lys Phe Ser Glu Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Thr Asn Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Gly  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Glu Lys Pro Glu  Glu Tyr Glu Lys Ile  Glu Ala Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Ile  Tyr Ala Pro Glu Lys  Asn Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Gln Gly Arg Val Gly  Ala Lys Val 
    1145                 1150                 1155             


Thr Ser  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Glu Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Met Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Val Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Val Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Glu Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asn Ala 
    1280                 1285                 1290             


Lys Asp  Lys Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Asp  Ala Glu Asp Ala Asp  Ser Lys Lys Pro Val  Ile Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Glu  Asp Glu Asp 
    1325                 1330                 1335             


Lys Gln  Lys Gly Lys Glu Asn  Arg Gly Lys Lys Asn  Thr Glu Thr 
    1340                 1345                 1350             


Arg Ser  Asp Ala Glu Lys Asn  Asn Asn Glu Arg Leu  Ser Tyr Asn 
    1355                 1360                 1365             


Pro Phe  Ala Asn Phe Asp Phe  Lys Leu Pro Asn Lys  
    1370                 1375                 1380 


<210>  144
<211>  1101
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  144

Met Arg Ile Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Ile Tyr Ser Glu 
            20                  25                  30          


Gln Ala Val Ser Asn Glu Thr Asn Asn Ile Leu Pro Val Lys Lys Met 
        35                  40                  45              


Asp Ser Phe Asn Leu Ser Ile Leu Asn Lys Thr Ile Ile Lys Phe Glu 
    50                  55                  60                  


Thr Val Lys Lys Gln Lys Leu Asn Leu Asp Gln Tyr Lys Ile Val Glu 
65                  70                  75                  80  


Lys Ile Phe Lys Tyr Pro Lys Gln Glu Leu Pro Lys Gln Ile Asn Ala 
                85                  90                  95      


Glu Glu Ile Leu Gln Phe Leu Asn His Lys Phe Gln Glu Pro Val Lys 
            100                 105                 110         


Tyr Trp Lys Asn Gly Lys Glu Glu Ser Phe Asn Leu Thr Leu Leu Ile 
        115                 120                 125             


Val Glu Ala Val Lys Thr Gln Glu Lys Arg Lys Leu Gln Pro Tyr Tyr 
    130                 135                 140                 


Asp Trp Lys Thr Trp Tyr Ile Gln Thr Lys Ser Asp Leu Leu Lys Lys 
145                 150                 155                 160 


Ser Ile Glu Asn Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg 
                165                 170                 175     


Lys Lys Ala Leu Leu Ala Trp Glu Thr Glu Phe Thr Thr Ser Gly Ser 
            180                 185                 190         


Ile Asp Leu Thr His Phe His Lys Val Tyr Met Thr Asp Val Leu Cys 
        195                 200                 205             


Thr Ala Leu Gln Lys Val Glu Pro Ser Ala Asp Glu Arg Gly Lys Met 
    210                 215                 220                 


Asn Ser Asn Ala Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Asn His 
225                 230                 235                 240 


Gln Pro Ala Ile Phe Gly Thr Arg Glu Ala Pro Asn Glu Val Asn Arg 
                245                 250                 255     


Ala Asp Asn Gln Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu 
            260                 265                 270         


Glu His Tyr Phe Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Ala Asp 
        275                 280                 285             


Asp Ile Ser His Tyr Leu Lys Ala Gln Thr Leu Lys Thr Thr Ile Glu 
    290                 295                 300                 


Lys Gln Leu Val Asn Ala Ile Arg Ala Asn Ile Ile Gln Gln Gly Lys 
305                 310                 315                 320 


Thr Asn His His Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile 
                325                 330                 335     


Arg Ile Lys Thr Asn Glu Ala Phe Val Leu Asn Leu Ile Gly Thr Cys 
            340                 345                 350         


Ala Phe Ala Ala Asn Asn Ile Arg Asn Met Val Asp Lys Glu Gln Ile 
        355                 360                 365             


Ser Asp Ile Leu Gly Lys Arg Glu Phe Ile Asp Ser Leu Thr Lys Ser 
    370                 375                 380                 


Arg Ile Ser Ser Gln Leu Tyr Ser Phe Phe Phe Gly Glu Asn Leu Ser 
385                 390                 395                 400 


Thr Asn Lys Ala Glu Lys Glu Thr Gln Leu Trp Gly Ile Arg Gly Ala 
                405                 410                 415     


Val Gln Gln Ile Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu 
            420                 425                 430         


Thr Thr Ile Phe Asn Ile Cys Lys Phe Glu Asn Pro Thr Asp Ala Asp 
        435                 440                 445             


Pro Lys Gln Gln Thr Asn Tyr Val Asp Ser Ile Tyr Lys Thr Leu Phe 
    450                 455                 460                 


Ile Lys Glu Leu Glu Lys Ile Pro Glu Ala Phe Ala Gln Gln Leu Lys 
465                 470                 475                 480 


Thr Gly Gly Ala Leu Ser Tyr Tyr Thr Val Glu Asn Leu Lys Thr Leu 
                485                 490                 495     


Leu Thr Thr Phe Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala 
            500                 505                 510         


Pro Gly Phe Lys Lys Val Leu Asn Gly Gly Ile Asn Tyr Gln Asn Ala 
        515                 520                 525             


Lys Gln Asp Glu Ser Phe Tyr Glu Leu Met Leu Glu Arg Tyr Leu Arg 
    530                 535                 540                 


Lys Glu Asn Phe Ala Glu Glu Ala Tyr Asn Ala Arg Tyr Phe Leu Leu 
545                 550                 555                 560 


Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Lys Phe Thr Ala Asp Arg 
                565                 570                 575     


Lys Ala Phe Ala Asp Ser Val Gly Phe Val Gln Leu Gln Asn Arg Lys 
            580                 585                 590         


Gln Ala Glu Asn Ser Lys Arg Pro Lys Ala Phe Ala Phe Glu Ala Val 
        595                 600                 605             


Arg Pro Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala Tyr Val 
    610                 615                 620                 


Gln Ser Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys Ala Thr 
625                 630                 635                 640 


Asp Glu Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val Phe Ile 
                645                 650                 655     


Lys Gly Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe Val Gln 
            660                 665                 670         


Val Pro Gln Pro Gln Leu Thr Thr Thr Asp Ser Asn Gln Gln Lys Ala 
        675                 680                 685             


Asp Lys Leu Asn Gln Leu Glu Ala Ser Ile Thr Ala Asp Cys Lys Leu 
    690                 695                 700                 


Thr Ala Gln Tyr Ala Lys Thr Asp Asp Ala Thr His Ile Ala Phe Tyr 
705                 710                 715                 720 


Val Phe Cys Lys Leu Leu Asp Ala Gly His Leu Ser Asn Leu Arg Asn 
                725                 730                 735     


Glu Leu Ile Lys Phe Arg Gly Ser Val Lys Asp Phe Asp Phe His His 
            740                 745                 750         


Leu Leu Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val Val Pro 
        755                 760                 765             


Thr Asp Tyr Arg Asp Leu Tyr Ser Ser Gly Ala Asp Cys Leu Ala Arg 
    770                 775                 780                 


Leu Arg Pro Phe Ile Glu Gln Gly Ala Asp Ile Lys Asn Trp Ser Asp 
785                 790                 795                 800 


Leu Tyr Val Gln Thr Asp Lys Gln Thr Pro Val Ile His Ala Gly Ile 
                805                 810                 815     


Glu Leu Ser Val Lys Tyr Gly Thr Thr Ala Leu Leu Glu Gln Leu Ile 
            820                 825                 830         


Thr Cys Asn Pro Lys Phe Arg Val Met Glu Asp Asn Phe Thr Lys Trp 
        835                 840                 845             


Ser Ala Gln Lys Lys Glu Ile Glu Glu Lys Val Asn Lys His Thr Asn 
    850                 855                 860                 


Leu His Gln Gln Trp Val Glu Ala Lys Glu Lys Asp Asp Arg Glu Arg 
865                 870                 875                 880 


Val Lys Ser Lys Lys Asn Phe Val Arg Glu Tyr Val Lys Lys Asn Tyr 
                885                 890                 895     


Val Asp Tyr Ile Asn Asn Cys Ile Glu Ile Asn Asn Tyr Asn Trp Leu 
            900                 905                 910         


Asp Asn Lys Leu His Phe Val His Leu Asn His Leu His His Leu Thr 
        915                 920                 925             


Ile Asp Ile Leu Gly Arg Met Ala Gly Phe Val Ala Leu Trp Glu Arg 
    930                 935                 940                 


Asp Phe Gln Tyr Ile Thr Lys Tyr Thr Ala Ala Lys Glu Gly Thr Asp 
945                 950                 955                 960 


Ala Leu Ser Phe Asp Gly Gly Leu Pro Arg Leu Lys Asp Lys Gln Glu 
                965                 970                 975     


Tyr Tyr Asn Lys Leu Phe Leu Ser Asp Lys Tyr Thr Lys Val Arg Asn 
            980                 985                 990         


His Ile Ala His Phe Asn Tyr Leu  Thr Lys Asp Ala Ala  Asp Phe Ala 
        995                 1000                 1005             


Leu Leu  Asp Leu Ile Asn Glu  Leu Arg Glu Leu Leu  His Tyr Gly 
    1010                 1015                 1020             


Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ala Phe Ile  Asp Leu Phe 
    1025                 1030                 1035             


Glu Lys  His Gly Met Ile Leu  Lys Leu Lys Leu Asn  Thr Asp His 
    1040                 1045                 1050             


Gln Leu  Val Val Glu Ser Ile  Glu Pro Lys Lys Ile  Tyr His Leu 
    1055                 1060                 1065             


Gly Ser  Thr Ala Lys Asp Lys  Pro Glu Tyr Gln Tyr  Thr Thr Asn 
    1070                 1075                 1080             


Gln Val  Met Thr Val Tyr Cys  Asn Met Cys Arg Ser  Leu Leu Glu 
    1085                 1090                 1095             


Met Lys  Lys 
    1100     


<210>  145
<211>  1007
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  145

Met Arg Val Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Val Tyr Ser Gly 
            20                  25                  30          


Gln Pro Val Ser Asn Glu Thr Cys Asn Ile Leu Pro Glu Lys Lys Arg 
        35                  40                  45              


Gln Ser Phe Asp Leu Ser Ile Glu Asn Lys Thr Leu Lys Arg Arg Asp 
    50                  55                  60                  


Asp Val Asp Lys Thr Lys Lys Gly Lys Tyr Asp Ile Val Arg Lys Ile 
65                  70                  75                  80  


Ile Lys Tyr Gly Glu Leu Pro Gln Ser Ile Asn Asp Val Asp Ile Leu 
                85                  90                  95      


Glu Phe Leu Asn His Lys Phe Gln Lys Pro Val Lys Tyr Trp Lys Asn 
            100                 105                 110         


Gly Lys Glu Glu Ser Phe Asn Leu Thr Leu Leu Ile Val Glu Ala Val 
        115                 120                 125             


Lys Thr Gln Asp Arg Gln Lys Leu Gln Pro Tyr Tyr Asp Trp Lys Thr 
    130                 135                 140                 


Trp Tyr Ile Gln Thr Lys Ser Asp Leu Leu Lys Lys Ser Ile Glu Asn 
145                 150                 155                 160 


Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg Lys Lys Ala Leu 
                165                 170                 175     


Leu Ala Trp Glu Thr Glu Phe Thr Thr Ser Gly Lys Ile Asp Leu Thr 
            180                 185                 190         


His Tyr His Lys Val Tyr Met Thr Asp Val Leu Cys Thr Ala Leu Gln 
        195                 200                 205             


Lys Val Glu Pro Ser Thr Asp Lys Lys Gly Lys Ile Asn Thr Asn Ala 
    210                 215                 220                 


Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Thr His Gln Pro Ala Ile 
225                 230                 235                 240 


Phe Gly Thr Arg Gln Ala Pro Asn Asn Val Asn Arg Ala Asp Asp Arg 
                245                 250                 255     


Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu Glu His Tyr Phe 
            260                 265                 270         


Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Ala Asp Asp Ile Glu His 
        275                 280                 285             


Tyr Leu Lys Thr Gln Thr Leu Lys Thr Thr Ile Glu Lys Gln Leu Val 
    290                 295                 300                 


Asn Ala Ile Arg Ala Asn Ile Ile Gln Gln Gly Lys Thr Asn His His 
305                 310                 315                 320 


Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile Arg Ile Lys Thr 
                325                 330                 335     


Asn Glu Ala Phe Val Leu Asn Leu Thr Gly Thr Cys Ala Phe Ala Ala 
            340                 345                 350         


Asn Asn Ile Arg Asn Met Val Asp Asn Glu Gln Thr Asn Asp Ile Leu 
        355                 360                 365             


Gly Lys Gly Asp Phe Ile Lys Ser Leu Leu Lys Asp Asn Thr Asn Gly 
    370                 375                 380                 


Gln Leu Tyr Ser Phe Phe Phe Gly Glu Ser Leu Ser Thr Asn Lys Ala 
385                 390                 395                 400 


Glu Lys Glu Thr Gln Leu Trp Gly Ile Arg Gly Ala Val Gln Gln Ile 
                405                 410                 415     


Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu Lys Thr Val Phe 
            420                 425                 430         


Asn Ile Ser Asn Phe Glu Asn Pro Thr Ile Thr Asp Pro Lys Gln Gln 
        435                 440                 445             


Thr Asn Tyr Ala Asp Thr Ile Tyr Lys Ala Leu Phe Ile Lys Glu Leu 
    450                 455                 460                 


Glu Lys Ile Pro Asn Ala Phe Ala Gln Gln Leu Lys Thr Gly Gly Ala 
465                 470                 475                 480 


Leu Ser Tyr Tyr Thr Ile Glu Asn Leu Lys Ser Leu Leu Thr Thr Phe 
                485                 490                 495     


Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala Pro Gly Phe Lys 
            500                 505                 510         


Lys Val Phe Asn Gly Gly Ile Asn Tyr Gln Asn Ala Lys Gln Asp Glu 
        515                 520                 525             


Ser Phe Tyr Glu Leu Met Leu Glu Arg Tyr Leu Arg Lys Glu Asn Phe 
    530                 535                 540                 


Ala Glu Glu Ala Tyr Asn Ala Arg Tyr Phe Leu Leu Lys Leu Ile Tyr 
545                 550                 555                 560 


Asn Asn Leu Phe Leu Pro Gly Phe Thr Arg Asp Arg Lys Ala Phe Ala 
                565                 570                 575     


Asp Ser Val Gly Phe Val Gln Met Gln Asn Lys Lys Gln Ala Glu Lys 
            580                 585                 590         


Val Asn Pro Lys Lys Arg Glu Ala Tyr Ala Phe Glu Ala Val Arg Pro 
        595                 600                 605             


Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala Tyr Val Gln Ser 
    610                 615                 620                 


Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys Ala Thr Asp Glu 
625                 630                 635                 640 


Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val Phe Val Lys Gly 
                645                 650                 655     


Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe Val Gln Val Pro 
            660                 665                 670         


Gln Pro Gln Leu Thr Ala Thr Ala Ser Asn Gln Gln Lys Ala Asp Lys 
        675                 680                 685             


Leu Asn Gln Leu Glu Ala Ser Ile Thr Ala Asp Cys Lys Leu Thr Pro 
    690                 695                 700                 


Gln Tyr Ala Lys Ala Asp Asn Ala Thr His Ile Ala Phe Tyr Val Phe 
705                 710                 715                 720 


Cys Lys Leu Leu Asp Ala Gly His Leu Ser Asn Leu Arg Asn Glu Leu 
                725                 730                 735     


Ile Lys Phe Arg Glu Ser Val Asn Glu Phe Lys Phe His His Leu Leu 
            740                 745                 750         


Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val Val Pro Thr Asp 
        755                 760                 765             


Tyr Arg Asp Leu Tyr Ser Ser Glu Ala Asp Cys Leu Ala Arg Leu Arg 
    770                 775                 780                 


Pro Phe Ile Glu Gln Gly Ala Asp Ile Thr Asn Trp Ser Asp Leu Phe 
785                 790                 795                 800 


Val Gln Ser Asp Lys His Ser Pro Val Ile His Ala Asn Ile Glu Leu 
                805                 810                 815     


Ser Val Lys Tyr Gly Thr Thr Lys Leu Leu Glu Gln Ile Ile Asn Lys 
            820                 825                 830         


Asp Pro Gln Phe Lys Thr Thr Glu Ala Asn Phe Thr Ala Trp Asn Thr 
        835                 840                 845             


Ala Gln Lys Ser Ile Glu Gln Leu Ile Lys Gln Arg Glu Asp His His 
    850                 855                 860                 


Glu Gln Trp Val Lys Ala Lys Asn Ala Asp Asp Lys Glu Lys Gln Glu 
865                 870                 875                 880 


Arg Lys Arg Glu Lys Ser Asn Phe Ala Gln Lys Phe Ile Glu Lys His 
                885                 890                 895     


Gly Asp Asp Tyr Leu Asp Ile Cys Asp Tyr Ile Asn Thr Tyr Asn Trp 
            900                 905                 910         


Leu Asp Asn Lys Met His Phe Val His Leu Asn Arg Leu His Gly Leu 
        915                 920                 925             


Thr Ile Glu Leu Leu Gly Arg Met Ala Gly Phe Val Ala Leu Phe Asp 
    930                 935                 940                 


Arg Asp Phe Gln Met Leu Asp Ala Lys Arg Ile Ser Asp Leu Tyr Gln 
945                 950                 955                 960 


Leu Lys Ser Phe Ile Ser Phe Arg Glu Ile Thr Ser Glu Leu Asp Lys 
                965                 970                 975     


Asn Asn Asp Ile Thr Glu Ile Asn Leu Ile Lys Asp Lys Glu Ile Ile 
            980                 985                 990         


Lys Arg Asp Gly Thr Pro Ile Thr  Glu Ala Asp Arg Asn  Ser Leu 
        995                 1000                 1005         


<210>  146
<211>  1101
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  146

Met Arg Ile Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Ile Tyr Ser Glu 
            20                  25                  30          


Gln Ala Val Ser Asn Glu Thr Asn Asn Ile Leu Pro Val Lys Lys Met 
        35                  40                  45              


Asp Ser Phe Asn Leu Ser Ile Leu Asn Lys Thr Ile Ile Lys Phe Glu 
    50                  55                  60                  


Thr Val Lys Lys Gln Lys Leu Asn Leu Asp Gln Tyr Lys Ile Val Glu 
65                  70                  75                  80  


Lys Ile Phe Lys Tyr Pro Lys Gln Glu Leu Pro Lys Gln Ile Asn Ala 
                85                  90                  95      


Glu Glu Ile Leu Gln Phe Leu Asn His Lys Phe Gln Glu Pro Val Lys 
            100                 105                 110         


Tyr Trp Lys Asn Gly Lys Glu Glu Ser Phe Asn Leu Thr Leu Leu Ile 
        115                 120                 125             


Val Glu Ala Val Lys Thr Gln Glu Lys Arg Lys Leu Gln Pro Tyr Tyr 
    130                 135                 140                 


Asp Trp Lys Thr Trp Tyr Ile Gln Thr Lys Ser Asp Leu Leu Lys Lys 
145                 150                 155                 160 


Ser Ile Glu Asn Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg 
                165                 170                 175     


Lys Lys Ala Leu Leu Ala Trp Glu Thr Glu Phe Thr Thr Ser Gly Ser 
            180                 185                 190         


Ile Asp Leu Thr His Phe His Lys Val Tyr Met Thr Asp Val Leu Cys 
        195                 200                 205             


Thr Ala Leu Gln Lys Val Glu Pro Ser Ala Asp Glu Arg Gly Lys Met 
    210                 215                 220                 


Asn Ser Asn Ala Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Asn His 
225                 230                 235                 240 


Gln Pro Ala Ile Phe Gly Thr Arg Glu Ala Pro Asn Glu Val Asn Arg 
                245                 250                 255     


Ala Asp Asn Gln Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu 
            260                 265                 270         


Glu His Tyr Phe Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Ala Asp 
        275                 280                 285             


Asp Ile Ser His Tyr Leu Lys Ala Gln Thr Leu Lys Thr Thr Ile Glu 
    290                 295                 300                 


Lys Gln Leu Val Asn Ala Ile Arg Ala Asn Ile Ile Gln Gln Gly Lys 
305                 310                 315                 320 


Thr Asn His His Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile 
                325                 330                 335     


Arg Ile Lys Thr Asn Glu Ala Phe Val Leu Asn Leu Ile Gly Thr Cys 
            340                 345                 350         


Ala Phe Ala Ala Asn Asn Ile Arg Asn Met Val Asp Lys Glu Gln Ile 
        355                 360                 365             


Ser Asp Ile Leu Gly Lys Arg Glu Phe Ile Asp Ser Leu Thr Lys Ser 
    370                 375                 380                 


Arg Ile Ser Ser Gln Leu Tyr Ser Phe Phe Phe Gly Glu Asn Leu Ser 
385                 390                 395                 400 


Thr Asn Lys Ala Glu Lys Glu Thr Gln Leu Trp Gly Ile Arg Gly Ala 
                405                 410                 415     


Val Gln Gln Ile Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu 
            420                 425                 430         


Thr Thr Ile Phe Asn Ile Cys Lys Phe Glu Asn Pro Thr Asp Ala Asp 
        435                 440                 445             


Pro Lys Gln Gln Thr Asn Tyr Val Asp Ser Ile Tyr Lys Thr Leu Phe 
    450                 455                 460                 


Ile Lys Glu Leu Glu Lys Ile Pro Glu Ala Phe Ala Gln Gln Leu Lys 
465                 470                 475                 480 


Thr Gly Gly Ala Leu Ser Tyr Tyr Thr Val Glu Asn Leu Lys Thr Leu 
                485                 490                 495     


Leu Thr Thr Phe Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala 
            500                 505                 510         


Pro Gly Phe Lys Lys Val Leu Asn Gly Gly Ile Asn Tyr Gln Asn Ala 
        515                 520                 525             


Lys Gln Asp Glu Ser Phe Tyr Glu Leu Met Leu Glu Arg Tyr Leu Arg 
    530                 535                 540                 


Lys Glu Asn Phe Ala Glu Glu Ala Tyr Asn Ala Arg Tyr Phe Leu Leu 
545                 550                 555                 560 


Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Lys Phe Thr Ala Asp Arg 
                565                 570                 575     


Lys Ala Phe Ala Asp Ser Val Gly Phe Val Gln Leu Gln Asn Arg Lys 
            580                 585                 590         


Gln Ala Glu Asn Ser Lys Arg Pro Lys Ala Phe Ala Phe Glu Ala Val 
        595                 600                 605             


Arg Pro Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala Tyr Val 
    610                 615                 620                 


Gln Ser Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys Ala Thr 
625                 630                 635                 640 


Asp Glu Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val Phe Ile 
                645                 650                 655     


Lys Gly Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe Val Gln 
            660                 665                 670         


Val Pro Gln Pro Gln Leu Thr Thr Thr Asp Ser Asn Gln Gln Lys Ala 
        675                 680                 685             


Asp Lys Leu Asn Gln Leu Glu Ala Ser Ile Thr Ala Asp Cys Lys Leu 
    690                 695                 700                 


Thr Ala Gln Tyr Ala Lys Thr Asp Asp Ala Thr His Ile Ala Phe Tyr 
705                 710                 715                 720 


Val Phe Cys Lys Leu Leu Asp Ala Gly His Leu Ser Asn Leu Arg Asn 
                725                 730                 735     


Glu Leu Ile Lys Phe Arg Gly Ser Val Lys Asp Phe Asp Phe His His 
            740                 745                 750         


Leu Leu Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val Val Pro 
        755                 760                 765             


Thr Asp Tyr Arg Asp Leu Tyr Ser Ser Gly Ala Asp Cys Leu Ala Arg 
    770                 775                 780                 


Leu Arg Pro Phe Ile Glu Gln Gly Ala Asp Ile Lys Asn Trp Ser Asp 
785                 790                 795                 800 


Leu Tyr Val Gln Thr Asp Lys Gln Thr Pro Val Ile His Ala Gly Ile 
                805                 810                 815     


Glu Leu Ser Val Lys Tyr Gly Thr Thr Ala Leu Leu Glu Gln Leu Ile 
            820                 825                 830         


Thr Cys Asn Pro Lys Phe Arg Val Met Glu Asp Asn Phe Thr Lys Trp 
        835                 840                 845             


Ser Ala Gln Lys Lys Glu Ile Glu Glu Lys Val Asn Lys His Thr Asn 
    850                 855                 860                 


Leu His Gln Gln Trp Val Glu Ala Lys Glu Lys Asp Asp Arg Glu Arg 
865                 870                 875                 880 


Val Lys Ser Lys Lys Asn Phe Val Arg Glu Tyr Val Lys Lys Asn Tyr 
                885                 890                 895     


Val Asp Tyr Ile Asn Asn Cys Ile Glu Ile Asn Asn Tyr Asn Trp Leu 
            900                 905                 910         


Asp Asn Lys Leu His Phe Val His Leu Asn His Leu His His Leu Thr 
        915                 920                 925             


Ile Asp Ile Leu Gly Arg Met Ala Gly Phe Val Ala Leu Trp Glu Arg 
    930                 935                 940                 


Asp Phe Gln Tyr Ile Thr Lys Tyr Thr Ala Ala Lys Glu Gly Thr Asp 
945                 950                 955                 960 


Ala Leu Ser Phe Asp Gly Gly Leu Pro Arg Leu Lys Asp Lys Gln Glu 
                965                 970                 975     


Tyr Tyr Asn Lys Leu Phe Leu Ser Asp Lys Tyr Thr Lys Val Arg Asn 
            980                 985                 990         


His Ile Ala His Phe Asn Tyr Leu  Thr Lys Asp Ala Ala  Asp Phe Ala 
        995                 1000                 1005             


Leu Leu  Asp Leu Ile Asn Glu  Leu Arg Glu Leu Leu  His Tyr Gly 
    1010                 1015                 1020             


Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ala Phe Ile  Asp Leu Phe 
    1025                 1030                 1035             


Glu Lys  His Gly Met Ile Leu  Lys Leu Lys Leu Asn  Thr Asp His 
    1040                 1045                 1050             


Gln Leu  Val Val Glu Ser Ile  Glu Pro Lys Lys Ile  Tyr His Leu 
    1055                 1060                 1065             


Gly Ser  Thr Ala Lys Asp Lys  Pro Glu Tyr Gln Tyr  Thr Thr Asn 
    1070                 1075                 1080             


Gln Val  Met Thr Val Tyr Cys  Asn Met Cys Arg Ser  Leu Leu Glu 
    1085                 1090                 1095             


Met Lys  Lys 
    1100     


<210>  147
<211>  1135
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  147

Met Lys Ile Thr Lys Ile Gly Gly Ile Ser His Lys Lys Tyr Glu Glu 
1               5                   10                  15      


Lys Gly Lys Leu Ile Lys Ser Asn Glu Ile Glu Lys Asp Val Ile Glu 
            20                  25                  30          


Glu Arg Phe Ser Asn Ile Glu Ala Lys Thr Thr Glu Leu Phe Ser Lys 
        35                  40                  45              


Thr Leu Asp Phe Tyr Val Lys Asn Tyr Glu Lys Cys Glu Glu Gln Asn 
    50                  55                  60                  


Lys Glu Arg Arg Glu Lys Ala Lys Asn Tyr Phe Ser Lys Val Lys Leu 
65                  70                  75                  80  


Ile Val Asp Asn Lys Lys Ile Thr Ile Phe Asn Glu Asn Thr Glu Lys 
                85                  90                  95      


Ile Glu Ile Glu Gly Phe Asn Glu Tyr Asp Val Arg Asp Glu Lys Tyr 
            100                 105                 110         


Phe Asn Val Leu Asn Lys Ile Leu Lys Glu Glu Asn Cys Thr Glu Glu 
        115                 120                 125             


Asp Leu Glu Val Phe Glu Asn Asp Leu Gln Lys Lys Leu Asn Gln Ile 
    130                 135                 140                 


Gln Ser Ile Lys Asn Ser Leu Glu Lys Asn Lys Ala His Phe Lys Lys 
145                 150                 155                 160 


Glu Ser Ile Asn Asn Thr Thr Asp Arg Val Lys Gly Asn Asn Lys Lys 
                165                 170                 175     


Ser Leu Phe Tyr Glu Tyr Tyr Arg Asn Ser Ser Lys His Gln Glu Tyr 
            180                 185                 190         


Val Asn Asn Ile Phe Glu Ala Phe Asp Lys Leu Tyr Ser Asn Ser His 
        195                 200                 205             


Glu Asp Ile Asn Asn Leu Phe Leu Glu Ile Thr Lys Asp Ser Asn Asn 
    210                 215                 220                 


Arg Asn Ile Arg Lys Ile Arg Glu Val Tyr Asn Glu Ile Leu Asn Lys 
225                 230                 235                 240 


Asn Lys Thr Glu Phe Gly Glu Glu Leu Tyr Lys Lys Ile Gln Asp Asn 
                245                 250                 255     


Ile Ser Asn Phe Asp Lys Leu Leu Glu Ile Glu Pro Glu Ile Lys Glu 
            260                 265                 270         


Leu Thr Lys Ser Gln Ile Phe Tyr Lys Tyr Tyr Ile Asp Lys Val Ser 
        275                 280                 285             


Leu Asp Gly Thr Asn Ile Lys His Cys Phe Ser His Leu Val Glu Ile 
    290                 295                 300                 


Glu Val Asn Gln Leu Leu Lys Asn Tyr Val Tyr Ser Lys Arg Ser Thr 
305                 310                 315                 320 


Asn Lys Glu Lys Leu Glu Asn Ile Phe Glu Tyr Cys Lys Leu Arg Asn 
                325                 330                 335     


Leu Val Lys Asn Lys Leu Val Asn Lys Leu Asn Asn Tyr Ile Arg Asn 
            340                 345                 350         


Cys Gly Lys Tyr Asn Ser Tyr Ile Asn Asn Asn Asp Val Val Asn Ser 
        355                 360                 365             


Glu Lys Ile Ser Glu Ile Arg Thr Lys Glu Ala Phe Leu Arg Ser Ile 
    370                 375                 380                 


Ile Gly Val Ser Ser Ser Ala Tyr Phe Ser Leu Arg Asn Ile Leu Asn 
385                 390                 395                 400 


Thr Asp Asn Thr Gln Asp Ile Thr Asn Lys Val Lys Gly Glu Val Glu 
                405                 410                 415     


Lys Leu Tyr Gln Glu Asn Lys Lys Val Lys Leu Glu Glu Arg Leu Lys 
            420                 425                 430         


Leu Phe Phe Gly Asn Asn Phe Asp Ile Asn Asn Gln Gln Glu Ile Glu 
        435                 440                 445             


Asp Phe Leu Met Asn Ile Asp Lys Ile Ile Ser Asn Ile Arg His Glu 
    450                 455                 460                 


Ile Ile His Phe Lys Ile Glu Ala Asn Ala His Ser Ile Phe Asp Phe 
465                 470                 475                 480 


Asn Asn Val Thr Leu Gly Asn Lys Ala Lys Asn Ile Phe Asn Asn Glu 
                485                 490                 495     


Ile Asn Glu Glu Arg Ile Lys Phe Lys Ile Phe Lys Gln Leu Asn Ser 
            500                 505                 510         


Ala Asn Val Phe Asp Tyr Leu Ser Asp Glu Asn Ile Thr Glu Tyr Met 
        515                 520                 525             


Gly Lys Val Ile Phe Ser Phe Thr Asn Arg Asn Ile Pro Phe Val Pro 
    530                 535                 540                 


Ser Phe Arg Lys Ile Tyr Asn Arg Val Gln Asp Leu Ala Asn Ser Leu 
545                 550                 555                 560 


Lys Ile Lys Glu Trp Lys Ile Ser Asp Glu Ser Glu Gly Lys Asp Ala 
                565                 570                 575     


Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asp Asp 
            580                 585                 590         


Phe Leu Asn Glu Lys Asn Glu Lys Phe Ile Lys Ile Lys Asp Glu Ile 
        595                 600                 605             


Ile Glu Leu Asn Lys Asn Gln Asn Lys Ile Thr Gly Phe Tyr Lys Leu 
    610                 615                 620                 


Glu Lys Phe Glu Lys Ile Glu Glu Lys Asn Pro Lys Lys Tyr Leu Glu 
625                 630                 635                 640 


Ile Ile Gln Ser Leu Tyr Met Ile Asn Ile Glu Glu Ile Asp Asn Glu 
                645                 650                 655     


Glu Lys Asn Ile Phe Leu Asp Phe Ile Gln Lys Ile Phe Leu Lys Gly 
            660                 665                 670         


Phe Phe Glu Phe Ile Lys Asn Asn Tyr Asn Tyr Leu Leu Glu Leu Lys 
        675                 680                 685             


Lys Ile Gln Asp Lys Lys Asn Ile Phe Asp Arg Glu Met Ser Glu Tyr 
    690                 695                 700                 


Ile Ala Gly Glu Lys Thr Leu Glu Asp Ile Gly Glu Ile Asn Glu Ile 
705                 710                 715                 720 


Ile Gln Lys Ile Glu Ile Thr Lys Ile Asp Lys Ile Leu Asn Leu Thr 
                725                 730                 735     


Asp Lys Ile Asn Cys Phe Tyr Leu Leu Leu Lys Leu Leu Asn Tyr Lys 
            740                 745                 750         


Glu Ile Thr Glu Leu Lys Gly Asn Leu Glu Lys Tyr Gln Ile Leu Ser 
        755                 760                 765             


Lys Thr Asp Ile Tyr Glu Lys Glu Leu Ile Leu Leu Asn Ile Val Asn 
    770                 775                 780                 


Leu Asp Asn Asn Lys Val Lys Ile Glu Lys Phe Lys Ile Ser Ala Glu 
785                 790                 795                 800 


Glu Ile Gly Lys Phe Ile Glu Lys Ile Ser Arg Asn Lys Lys Ile Lys 
                805                 810                 815     


Thr Phe Glu Glu Leu Arg Asn Phe Glu Lys Arg Glu Asn Thr Gly Glu 
            820                 825                 830         


Tyr Tyr Asn Val Tyr Ser Asp Asp Lys Asn Ile Lys Asn Ile Arg Asn 
        835                 840                 845             


Leu Tyr Asn Ile Lys Lys Tyr Gly Met Leu Asp Leu Leu Glu Arg Ile 
    850                 855                 860                 


Ser Glu Lys Ser Asn Tyr Cys Ile Lys Lys Glu Asp Leu Lys Glu Tyr 
865                 870                 875                 880 


Asp Lys Leu Lys Lys Lys Leu Glu Asp Lys Lys Thr Asp Phe Tyr Lys 
                885                 890                 895     


Ile Gln Lys Asp Leu His Tyr Lys Tyr Gln Lys Glu Tyr Lys Asn Phe 
            900                 905                 910         


Ser Lys Lys Asn Asn Thr Glu Asp Tyr Glu Lys Tyr Lys Glu Ser Ile 
        915                 920                 925             


Glu Asn Ile Glu Lys Tyr Val His Leu Lys Asn Lys Ile Glu Phe Asn 
    930                 935                 940                 


Glu Leu Asn Leu Leu Gln Ser Leu Leu Leu Lys Ile Leu His Arg Leu 
945                 950                 955                 960 


Val Gly Phe Thr Ser Ile Trp Glu Arg Asp Leu Arg Phe Arg Leu Ile 
                965                 970                 975     


Gly Glu Phe Pro Asp Glu Leu Asp Val Glu Asp Ile Phe Asp His Arg 
            980                 985                 990         


Glu Arg Tyr Arg Gly Thr Arg Gly  Gln Ile Cys Lys Lys  Tyr Asp Gln 
        995                 1000                 1005             


Phe Ile  Ser Val His Ile Glu  Tyr Gln Asn Asn Lys  Lys Met Lys 
    1010                 1015                 1020             


Asn Ile  Lys Phe Asp Asp Asn  Asn Pro Ile Arg Asn  Tyr Ile Ala 
    1025                 1030                 1035             


His Phe  Asn Tyr Leu Pro Thr  Pro Lys Tyr Ser Ile  Leu Lys Met 
    1040                 1045                 1050             


Leu Gly  Lys Leu Arg Glu Leu  Leu Asp Tyr Asp Arg  Lys Leu Lys 
    1055                 1060                 1065             


Asn Ala  Val Met Lys Ser Ile  Lys Asp Ile Leu Glu  Glu Tyr Gly 
    1070                 1075                 1080             


Phe Lys  Ala Glu Phe Val Ile  Asn Pro Asp Lys Glu  Ile Ile Leu 
    1085                 1090                 1095             


Asn Ser  Val Lys Ser Val Glu  Ile Ile His Leu Lys  Lys Asn Asp 
    1100                 1105                 1110             


Leu Asn  Ser His Arg Asn Ser  Glu Asp Leu Cys Lys  Leu Val Lys 
    1115                 1120                 1125             


Ala Met  Leu Glu Tyr Ser Glu  
    1130                 1135 


<210>  148
<211>  1386
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  148

Met Gly Asn Leu Phe Gly His Lys Arg Trp Tyr Glu Val Pro Asp Lys 
1               5                   10                  15      


Lys Gly Phe Lys Ile Lys Arg Lys Val Lys Val Lys Arg Asn Tyr Asp 
            20                  25                  30          


Gly Asn Lys Tyr Ile Leu Asn Ile Asn Glu Asn Asn Asn Lys Glu Lys 
        35                  40                  45              


Ile Asp Asn Asn Lys Phe Ile Arg Lys Tyr Ile Asn Tyr Lys Lys Asn 
    50                  55                  60                  


Asp Asn Ile Leu Lys Glu Phe Thr Arg Lys Phe His Ala Gly Asn Ile 
65                  70                  75                  80  


Leu Phe Lys Leu Lys Gly Lys Glu Gly Ile Ile Arg Ile Glu Asn Asn 
                85                  90                  95      


Asp Asp Phe Leu Glu Thr Glu Glu Val Val Leu Tyr Ile Glu Ala Tyr 
            100                 105                 110         


Gly Lys Ser Glu Lys Leu Lys Ala Leu Gly Ile Thr Lys Lys Lys Ile 
        115                 120                 125             


Ile Asp Glu Ala Ile Arg Gln Gly Ile Thr Lys Asp Asp Lys Lys Ile 
    130                 135                 140                 


Glu Ile Lys Arg Gln Glu Asn Glu Glu Glu Ile Glu Ile Asp Ile Arg 
145                 150                 155                 160 


Asp Glu Tyr Thr Asn Lys Thr Leu Asn Asp Cys Ser Ile Ile Leu Arg 
                165                 170                 175     


Ile Ile Glu Asn Asp Glu Leu Glu Thr Lys Lys Ser Ile Tyr Glu Ile 
            180                 185                 190         


Phe Lys Asn Ile Asn Met Ser Leu Tyr Lys Ile Ile Glu Lys Ile Ile 
        195                 200                 205             


Glu Asn Glu Thr Glu Lys Val Phe Glu Asn Arg Tyr Tyr Glu Glu His 
    210                 215                 220                 


Leu Arg Glu Lys Leu Leu Lys Asp Asp Lys Ile Asp Val Ile Leu Thr 
225                 230                 235                 240 


Asn Phe Met Glu Ile Arg Glu Lys Ile Glu Ser Asn Leu Glu Ile Met 
                245                 250                 255     


Gly Phe Val Lys Phe Tyr Leu Asn Val Gly Gly Asp Lys Lys Lys Ser 
            260                 265                 270         


Glu Asn Lys Lys Ile Leu Val Glu Lys Ile Leu Asn Ile Asn Val Asp 
        275                 280                 285             


Leu Thr Val Glu Asp Ile Ala Asp Phe Val Ile Lys Glu Leu Glu Phe 
    290                 295                 300                 


Trp Asn Ile Thr Lys Arg Ile Glu Lys Val Lys Lys Val Asn Asn Glu 
305                 310                 315                 320 


Phe Leu Glu Lys Arg Arg Asn Arg Thr Tyr Ile Lys Ser Tyr Val Leu 
                325                 330                 335     


Leu Asp Lys His Glu Lys Phe Lys Ile Glu Arg Glu Asn Lys Lys Asp 
            340                 345                 350         


Lys Ile Val Lys Phe Phe Val Glu Asn Ile Lys Asn Asn Ser Ile Lys 
        355                 360                 365             


Glu Lys Ile Glu Lys Ile Leu Ala Glu Phe Lys Ile Asp Glu Leu Ile 
    370                 375                 380                 


Lys Lys Leu Glu Lys Glu Leu Lys Lys Gly Asn Cys Asp Thr Glu Ile 
385                 390                 395                 400 


Phe Gly Ile Phe Lys Lys His Tyr Lys Val Asn Phe Asp Ser Lys Lys 
                405                 410                 415     


Phe Ser Lys Lys Ser Asp Glu Glu Lys Glu Leu Tyr Lys Ile Ile Tyr 
            420                 425                 430         


Arg Tyr Leu Lys Gly Arg Ile Glu Lys Ile Leu Ile Ser Glu Glu Lys 
        435                 440                 445             


Val Arg Leu Lys Lys Met Lys Lys Ile Glu Ile Glu Lys Ile Leu Asn 
    450                 455                 460                 


Lys Ser Ile Leu Ser Lys Lys Val Leu Lys Arg Val Lys Gln Tyr Thr 
465                 470                 475                 480 


Leu Glu His Val Met Tyr Leu Gly Lys Leu Val His Asn Asp Ile Asp 
                485                 490                 495     


Met Thr Thr Val Asn Thr Asn Asp Phe Ser Met Leu His Ala Lys Glu 
            500                 505                 510         


Glu Leu Asp Leu Glu Leu Ile Thr Phe Phe Ala Ser Thr Asn Met Glu 
        515                 520                 525             


Leu Asn Lys Ile Phe Asn Gly Lys Glu Lys Val Thr Asp Phe Phe Gly 
    530                 535                 540                 


Phe Asn Leu Thr Gly Gln Lys Ile Thr Leu Lys Glu Lys Val Pro Ser 
545                 550                 555                 560 


Phe Lys Leu Asn Ile Leu Lys Lys Leu Asn Phe Ile Asn Asn Glu Asn 
                565                 570                 575     


Asn Ile Asp Glu Lys Leu Ser His Phe Tyr Ser Phe Gln Lys Glu Gly 
            580                 585                 590         


Tyr Leu Leu Arg Asn Lys Ile Leu His Asn Ser Tyr Gly Asn Ile Gln 
        595                 600                 605             


Glu Thr Lys Asn Leu Glu Glu Glu Tyr Glu Asn Val Thr Asn Leu Ile 
    610                 615                 620                 


Asp Glu Leu Lys Val Ser Asp Glu Glu Ile Ser Lys Ser Leu Asn Leu 
625                 630                 635                 640 


Asp Ile Ile Phe Glu Gly Lys Val Asp Ile Ile Asn Lys Ile Asn Ser 
                645                 650                 655     


Leu Glu Ile Gly Glu Tyr Lys Asp Lys Lys Tyr Leu Pro Ser Phe Ser 
            660                 665                 670         


Lys Ile Val Pro Glu Ile Thr Arg Lys Phe Arg Glu Ile Asn Lys Asp 
        675                 680                 685             


Lys Ser Phe Asp Ile Glu Ser Glu Lys Ile Ile Leu Asn Ala Val Lys 
    690                 695                 700                 


Tyr Val Asn Lys Ile Leu Tyr Glu Lys Ile Thr Ser Asn Glu Glu Asn 
705                 710                 715                 720 


Gln Phe Ile Lys Thr Leu Pro Asp Lys Leu Val Lys Lys Asn Asn Asn 
                725                 730                 735     


Lys Glu Asn Lys Asn Ser Leu Ser Ile Glu Glu Tyr Tyr Lys Asn Ala 
            740                 745                 750         


Gln Ile Ser Ser Ser Lys Gly Asp Lys Lys Ala Ile Lys Lys Tyr Gln 
        755                 760                 765             


Asn Lys Val Thr Asn Ala Tyr Leu Glu Tyr Leu Glu Asn Thr Phe Ala 
    770                 775                 780                 


Glu Val Ile Ser Phe Ser Asn Phe Asn Leu Asn Phe Asp Glu Ile Lys 
785                 790                 795                 800 


Thr Lys Ile Glu Glu Arg Lys Asp Ser Lys Ser Lys Ile Thr Ile Asp 
                805                 810                 815     


Ser Ile Ser Thr Asn Ile Asn Ile Thr Asn Asp Ile Glu Tyr Ile Ile 
            820                 825                 830         


Ser Ile Phe Ala Leu Leu Asn Ser Asn Thr Tyr Ile Asn Lys Ile Arg 
        835                 840                 845             


Asn Arg Phe Phe Ala Thr Ser Val Trp Leu Glu Lys Gln Asn Ser Thr 
    850                 855                 860                 


Lys Glu Tyr Asp Tyr Glu Asn Ile Ile Ser Ile Leu Asp Glu Ile Leu 
865                 870                 875                 880 


Leu Thr Asn Leu Leu Arg Glu Asn Asn Ile Thr Asp Ile Leu Asp Leu 
                885                 890                 895     


Lys Asn Ala Ile Ile Asp Ala Lys Ile Ala Glu Asn Asp Glu Ala Tyr 
            900                 905                 910         


Ile Lys Asn Tyr Ile Phe Glu Ser Asn Glu Glu Lys Leu Lys Lys Arg 
        915                 920                 925             


Leu Phe Cys Glu Glu Leu Ile Asp Lys Glu Asp Ile Arg Lys Ile Phe 
    930                 935                 940                 


Glu Asp Lys Asn Phe Lys Phe Lys Asn Phe Ile Lys Lys Thr Glu Asn 
945                 950                 955                 960 


Glu Asn Phe Thr Ile Asn Phe Asp Asn Leu Phe Asn Leu Glu Cys Asn 
                965                 970                 975     


Ser Glu Leu Asn Val Lys Lys Val Ile Gly Gln Asn Ser Gln Arg Leu 
            980                 985                 990         


Asn Leu Phe Ile Lys Asn Thr Ile  Asp Glu Tyr Lys Ser  Lys Ile Lys 
        995                 1000                 1005             


Thr Ser  Phe Ser Ser Glu Phe  Leu Glu Lys Tyr Lys  Gly Ile Ile 
    1010                 1015                 1020             


Asp Asn  Leu Ile Glu Asn Glu  Asn Lys Phe Glu Lys  Ile Tyr Tyr 
    1025                 1030                 1035             


Pro Glu  Glu His Lys Asn Glu  Leu Tyr Ile Tyr Lys  Lys Asn Leu 
    1040                 1045                 1050             


Phe Leu  Asn Ile Gly Asn Pro  Asn Phe Asp Lys Ile  Tyr Gly Leu 
    1055                 1060                 1065             


Ile Ser  Asn Asp Ile Lys Val  Ala Asp Ala Lys Phe  Leu Phe Asp 
    1070                 1075                 1080             


Ser Asp  Gly Glu Asp Ile Arg  Asn Asn Lys Ile Ser  Glu Ile Asp 
    1085                 1090                 1095             


Ala Ile  Leu Lys Asn Leu Asn  Asp Lys Leu Asn Gly  Tyr Ser Lys 
    1100                 1105                 1110             


Glu Tyr  Lys Glu Lys Tyr Ile  Lys Lys Leu Lys Glu  Asn Asn Asp 
    1115                 1120                 1125             


Phe Phe  Lys Lys Asn Ile Gln  Asn Glu Asn Tyr Asn  Ser Phe Glu 
    1130                 1135                 1140             


Glu Phe  Lys Glu Asp Tyr Asn  Lys Val Ser Glu Tyr  Lys Arg Ile 
    1145                 1150                 1155             


Arg Asp  Leu Val Glu Phe Asn  Tyr Leu Asn Lys Ile  Glu Ser Tyr 
    1160                 1165                 1170             


Leu Ile  Asp Ile Asn Trp Lys  Leu Ala Ile Gln Met  Ala Arg Phe 
    1175                 1180                 1185             


Glu Arg  Asp Met His Tyr Ile  Val Asn Gly Leu Asp  Tyr Leu Tyr 
    1190                 1195                 1200             


Ile Ile  Arg Leu Glu Lys Asn  Arg Asn Gln Asp Arg  Ser Ser Pro 
    1205                 1210                 1215             


Tyr Pro  Lys Tyr Lys Asn Gly  Val Leu Asp Tyr Thr  Lys Ser Tyr 
    1220                 1225                 1230             


Tyr Asn  Phe Lys Asp Tyr Gln  Glu Phe Met Asp Ile  Cys Leu Lys 
    1235                 1240                 1245             


Phe Gly  Ile Asp Leu Ser Glu  Asn Ser Glu Ile Asn  Lys Pro Glu 
    1250                 1255                 1260             


Asn Glu  Ser Ile Arg Asn Tyr  Ile Ser His Phe Tyr  Ile Val Arg 
    1265                 1270                 1275             


Asn Pro  Phe Ala Asp Tyr Ser  Ile Ala Glu Gln Ile  Asp Arg Val 
    1280                 1285                 1290             


Ser Asn  Leu Leu Ser Tyr Ser  Thr Arg Tyr Asn Asn  Ser Thr Tyr 
    1295                 1300                 1305             


Ala Ser  Val Phe Glu Val Phe  Lys Lys Asp Val Asn  Leu Asp Tyr 
    1310                 1315                 1320             


Asp Lys  Leu Lys Thr Lys Phe  Lys Leu Phe Asp Asp  Glu Lys Asn 
    1325                 1330                 1335             


Asp Asn  Ile Lys Ile Leu Lys  Ile Glu Asn Leu Ile  Glu Ser Lys 
    1340                 1345                 1350             


Lys Val  Ser Val Leu Glu Leu  Glu Ser Tyr Asn Ser  Asp Tyr Ile 
    1355                 1360                 1365             


Lys Asn  Leu Ile Ile Glu Leu  Leu Thr Lys Ile Glu  Asn Thr Asn 
    1370                 1375                 1380             


Asp Thr  Leu 
    1385     


<210>  149
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  149

Met Lys Ile Thr Lys Ile Asp Gly Ile Leu His Lys Lys Tyr Ile Lys 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Lys Thr Asp Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Thr Ile Arg Leu Asp Thr Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Thr Leu 
    50                  55                  60                  


Lys Glu Phe Phe Ser Asn Lys Val Leu Tyr Leu Lys Asp Ser Ile Leu 
65                  70                  75                  80  


Tyr Leu Lys Asp Arg Arg Glu Lys Asn Gln Leu Gln Asn Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Leu Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Asn Asp Phe Glu Lys Lys Leu Asp Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Leu Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Ile Lys Lys Val Glu Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Phe Tyr Asn Tyr Tyr Lys Asp Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Ile Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Asn Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Thr Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Met 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asn Val Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asn Lys Glu Lys Leu Asn Asp Glu 
        275                 280                 285             


Asn Ile Lys Tyr Val Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Ser Phe Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Val Gly Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Thr Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Ile Lys Gly Lys Thr Val Lys Asn Lys 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Ile Ser Gly Glu Ile Asp Lys Leu Tyr Asp 
            420                 425                 430         


Asn Asn Lys Gln Asn Glu Val Lys Lys Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asn Arg Lys Lys Glu Ile Glu Asp Phe Phe Ser 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Thr Phe Lys Asn Ile Val 
                485                 490                 495     


Pro Ser Gln Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Asn Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Cys Ile Tyr Trp 
                565                 570                 575     


Lys Ile Pro Lys Ala Asn Asp Asn Asn Lys Thr Lys Glu Ile Thr Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ile Lys Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asn Leu Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Phe Tyr Met Ile Asp Ala Gly Asn Lys Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Ala Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Met 
    690                 695                 700                 


Tyr Ile Gly Asn Asp Glu Gln Ile Asn Thr Ser Leu Ala Gly Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Lys Ile Leu Lys Tyr Thr Glu Ser Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Ala Phe Ser Asp Gln Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Val Lys Asp Asn Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Ile Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Ile Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Asn Asp Glu Asp Tyr Lys 
        915                 920                 925             


Lys Tyr Glu Lys Thr Ile Arg Asn Ile Gln Gln Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Ser Leu Leu Leu 
945                 950                 955                 960 


Arg Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Asn Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Ser Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asp  Met Glu Lys Ile Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Glu Leu  Lys Lys Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  Asn Ala Glu Val Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Ile Met Lys Ser  Ile Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Val Thr Phe Lys  Ile Glu Lys Asp Lys  Lys Ile Arg 
    1100                 1105                 1110             


Ile Glu  Ser Leu Lys Ser Glu  Glu Val Val His Leu  Lys Lys Leu 
    1115                 1120                 1125             


Lys Leu  Lys Asp Asn Asp Lys  Lys Lys Glu Pro Ile  Lys Thr Tyr 
    1130                 1135                 1140             


Arg Asn  Ser Lys Glu Leu Cys  Lys Leu Val Lys Val  Met Phe Glu 
    1145                 1150                 1155             


Tyr Lys  Met Lys Glu Lys Lys  Ser Glu Asn 
    1160                 1165             


<210>  150
<211>  1357
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  150

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Pro Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Lys Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Arg Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Asp Ile Gln Lys Ile Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Lys Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Cys Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Thr Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Ile Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Glu Pro Glu Asn Leu Ser Gln Gln Lys Lys Glu Lys 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Ala Leu Glu Gly Glu Ser 
    450                 455                 460                 


Val Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Glu Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Ala Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Arg Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Ser Ala Ile Lys Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Lys Gly Asp Lys Glu Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Glu Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Ser Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Lys Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Ala Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Glu Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Val Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Val Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Tyr  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Thr Val Leu Lys Glu  Gly Ile Cys 
    1055                 1060                 1065             


Arg Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Leu Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ala Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asp  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Val Leu Val Pro Ala  Arg Ser Glu 
    1325                 1330                 1335             


Val Phe  Leu Lys Gln Phe Arg  Lys Ile Leu Glu Tyr  Arg Ile Gln 
    1340                 1345                 1350             


Asp Lys  Thr Gln 
    1355         


<210>  151
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  151

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Thr Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Lys Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Glu 
        755                 760                 765             


Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Lys Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Ile  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1400                 1405                 1410         


<210>  152
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  152

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Gly Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Arg Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asp 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  153
<211>  1380
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  153

Met Lys Leu Ser Lys Glu Lys Gln Ile Arg Ser Ala Val Ala Asn Lys 
1               5                   10                  15      


Glu Lys Asn Thr Glu Gly Val Leu Tyr Arg Phe Pro Gly Asp Asp Ile 
            20                  25                  30          


Gly Gly Val Gln Ala Gln Met Leu Val Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Leu Gly Asn Lys Pro Lys Glu 
    50                  55                  60                  


Trp Met Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Lys Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Ala Ile Asn Asp Ile Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Lys Glu Ala Asp Lys Lys Ile Arg Asn Met Ser Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Asn Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Ser Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Gly Asn Gln Glu Phe Asp Ser Ile Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Asp Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Ser Ile Gln Asp Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Ile Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Glu Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Asp Gly Leu Asn Glu Phe Met Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Glu Glu Lys Arg Ala Glu Val Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Ile His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Val Asn Lys Gly Lys Phe Tyr Val Trp 
305                 310                 315                 320 


Lys Lys His Glu Cys Gly Lys Lys Glu Asn Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Val Glu Ala Glu Ala Glu Ser Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Ile Phe Phe Glu Asn Asp Thr Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Thr Gly Thr Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Lys Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asn Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Gln Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Leu 
            660                 665                 670         


Val Arg Thr Val Phe Pro Glu Tyr Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Asn Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Arg Thr Leu Arg Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Lys 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Glu Asn Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Cys Ala Gln Asp 
            900                 905                 910         


Ile Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu 
        915                 920                 925             


Leu Ser Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Lys Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Lys Phe Ser Glu Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Thr Asn Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Gly  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Glu Lys Pro Glu  Glu Tyr Glu Lys Ile  Glu Ala Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Ile  Tyr Ala Pro Glu Lys  Asn Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Gln Gly Arg Val Gly  Ala Lys Val 
    1145                 1150                 1155             


Thr Ser  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Glu Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Met Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Val Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Val Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Glu Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asn Ala 
    1280                 1285                 1290             


Lys Asp  Lys Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Asp  Ala Glu Asp Ala Asp  Ser Lys Lys Pro Val  Ile Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Glu  Asp Glu Asp 
    1325                 1330                 1335             


Lys Gln  Lys Gly Lys Glu Asn  Arg Gly Lys Lys Asn  Thr Glu Thr 
    1340                 1345                 1350             


Arg Ser  Asp Ala Glu Lys Asn  Asn Asn Glu Arg Leu  Ser Tyr Asn 
    1355                 1360                 1365             


Pro Phe  Ala Asn Phe Asp Phe  Lys Leu Pro Asn Lys  
    1370                 1375                 1380 


<210>  154
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  154

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Gly Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn Tyr Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Gly Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Gly Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Ser Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  155
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  155

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  156
<211>  1101
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  156

Met Arg Ile Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Ile Tyr Ser Glu 
            20                  25                  30          


Gln Ala Val Ser Asn Glu Thr Asn Asn Ile Leu Pro Val Lys Lys Met 
        35                  40                  45              


Asp Ser Phe Asn Leu Ser Ile Leu Asn Lys Thr Ile Ile Lys Phe Glu 
    50                  55                  60                  


Thr Val Lys Lys Gln Lys Leu Asn Leu Asp Gln Tyr Lys Ile Val Glu 
65                  70                  75                  80  


Lys Ile Phe Lys Tyr Pro Lys Gln Glu Leu Pro Lys Gln Ile Asn Ala 
                85                  90                  95      


Glu Glu Ile Leu Gln Phe Leu Asn His Lys Phe Gln Glu Pro Val Lys 
            100                 105                 110         


Tyr Trp Lys Asn Gly Lys Glu Glu Ser Phe Asn Leu Thr Leu Leu Ile 
        115                 120                 125             


Val Glu Ala Val Lys Thr Gln Glu Lys Arg Lys Leu Gln Pro Tyr Tyr 
    130                 135                 140                 


Asp Trp Lys Thr Trp Tyr Ile Gln Thr Lys Ser Asp Leu Leu Lys Lys 
145                 150                 155                 160 


Ser Ile Glu Asn Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg 
                165                 170                 175     


Lys Lys Ala Leu Leu Ala Trp Glu Thr Glu Phe Thr Thr Ser Gly Ser 
            180                 185                 190         


Ile Asp Leu Thr His Phe His Lys Val Tyr Met Thr Asp Val Leu Cys 
        195                 200                 205             


Thr Ala Leu Gln Lys Val Glu Pro Ser Ala Asp Glu Arg Gly Lys Met 
    210                 215                 220                 


Asn Ser Asn Ala Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Asn His 
225                 230                 235                 240 


Gln Pro Ala Ile Phe Gly Thr Arg Glu Ala Pro Asn Glu Val Asn Arg 
                245                 250                 255     


Ala Asp Asn Gln Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu 
            260                 265                 270         


Glu His Tyr Phe Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Ala Asp 
        275                 280                 285             


Asp Ile Ser His Tyr Leu Lys Ala Gln Thr Leu Lys Thr Thr Ile Glu 
    290                 295                 300                 


Lys Gln Leu Val Asn Ala Ile Arg Ala Asn Ile Ile Gln Gln Gly Lys 
305                 310                 315                 320 


Thr Asn His His Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile 
                325                 330                 335     


Arg Ile Lys Thr Asn Glu Ala Phe Val Leu Asn Leu Ile Gly Thr Cys 
            340                 345                 350         


Ala Phe Ala Ala Asn Asn Ile Arg Asn Met Val Asp Lys Glu Gln Ile 
        355                 360                 365             


Ser Asp Ile Leu Gly Lys Arg Glu Phe Ile Asp Ser Leu Thr Lys Ser 
    370                 375                 380                 


Arg Ile Ser Ser Gln Leu Tyr Ser Phe Phe Phe Gly Glu Asn Leu Ser 
385                 390                 395                 400 


Thr Asn Lys Ala Glu Lys Glu Thr Gln Leu Trp Gly Ile Arg Gly Ala 
                405                 410                 415     


Val Gln Gln Ile Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu 
            420                 425                 430         


Thr Thr Ile Phe Asn Ile Cys Lys Phe Glu Asn Pro Thr Asp Ala Asp 
        435                 440                 445             


Pro Lys Gln Gln Thr Asn Tyr Val Asp Ser Ile Tyr Lys Thr Leu Phe 
    450                 455                 460                 


Ile Lys Glu Leu Glu Lys Ile Pro Glu Ala Phe Ala Gln Gln Leu Lys 
465                 470                 475                 480 


Thr Gly Gly Ala Leu Ser Tyr Tyr Thr Val Glu Asn Leu Lys Thr Leu 
                485                 490                 495     


Leu Thr Thr Phe Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala 
            500                 505                 510         


Pro Gly Phe Lys Lys Val Leu Asn Gly Gly Ile Asn Tyr Gln Asn Ala 
        515                 520                 525             


Lys Gln Asp Glu Ser Phe Tyr Glu Leu Met Leu Glu Arg Tyr Leu Arg 
    530                 535                 540                 


Lys Glu Asn Phe Ala Glu Glu Ala Tyr Asn Ala Arg Tyr Phe Leu Leu 
545                 550                 555                 560 


Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Lys Phe Thr Ala Asp Arg 
                565                 570                 575     


Lys Ala Phe Ala Asp Ser Val Gly Phe Val Gln Leu Gln Asn Arg Lys 
            580                 585                 590         


Gln Ala Glu Asn Ser Lys Arg Pro Lys Ala Phe Ala Phe Glu Ala Val 
        595                 600                 605             


Arg Pro Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala Tyr Val 
    610                 615                 620                 


Gln Ser Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys Ala Thr 
625                 630                 635                 640 


Asp Glu Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val Phe Ile 
                645                 650                 655     


Lys Gly Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe Val Gln 
            660                 665                 670         


Val Pro Gln Pro Gln Leu Thr Thr Thr Asp Ser Asn Gln Gln Lys Ala 
        675                 680                 685             


Asp Lys Leu Asn Gln Leu Glu Ala Ser Ile Thr Ala Asp Cys Lys Leu 
    690                 695                 700                 


Thr Ala Gln Tyr Ala Lys Thr Asp Asp Ala Thr His Ile Ala Phe Tyr 
705                 710                 715                 720 


Val Phe Cys Lys Leu Leu Asp Ala Gly His Leu Ser Asn Leu Arg Asn 
                725                 730                 735     


Glu Leu Ile Lys Phe Arg Gly Ser Val Lys Asp Phe Asp Phe His His 
            740                 745                 750         


Leu Leu Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val Val Pro 
        755                 760                 765             


Thr Asp Tyr Arg Asp Leu Tyr Ser Ser Gly Ala Asp Cys Leu Ala Arg 
    770                 775                 780                 


Leu Arg Pro Phe Ile Glu Gln Gly Ala Asp Ile Lys Asn Trp Ser Asp 
785                 790                 795                 800 


Leu Tyr Val Gln Thr Asp Lys Gln Thr Pro Val Ile His Ala Gly Ile 
                805                 810                 815     


Glu Leu Ser Val Lys Tyr Gly Thr Thr Ala Leu Leu Glu Gln Leu Ile 
            820                 825                 830         


Thr Cys Asn Pro Lys Phe Arg Val Met Glu Asp Asn Phe Thr Lys Trp 
        835                 840                 845             


Ser Ala Gln Lys Lys Glu Ile Glu Glu Lys Val Asn Lys His Thr Asn 
    850                 855                 860                 


Leu His Gln Gln Trp Val Glu Ala Lys Glu Lys Asp Asp Arg Glu Arg 
865                 870                 875                 880 


Val Lys Ser Lys Lys Asn Phe Val Arg Glu Tyr Val Lys Lys Asn Tyr 
                885                 890                 895     


Val Asp Tyr Ile Asn Asn Cys Ile Glu Ile Asn Asn Tyr Asn Trp Leu 
            900                 905                 910         


Asp Asn Lys Leu His Phe Val His Leu Asn His Leu His His Leu Thr 
        915                 920                 925             


Ile Asp Ile Leu Gly Arg Met Ala Gly Phe Val Ala Leu Trp Glu Arg 
    930                 935                 940                 


Asp Phe Gln Tyr Ile Thr Lys Tyr Thr Ala Ala Lys Glu Gly Thr Asp 
945                 950                 955                 960 


Ala Leu Ser Phe Asp Gly Gly Leu Pro Arg Leu Lys Asp Lys Gln Glu 
                965                 970                 975     


Tyr Tyr Asn Lys Leu Phe Leu Ser Asp Lys Tyr Thr Lys Val Arg Asn 
            980                 985                 990         


His Ile Ala His Phe Asn Tyr Leu  Thr Lys Asp Ala Ala  Asp Phe Ala 
        995                 1000                 1005             


Leu Leu  Asp Leu Ile Asn Glu  Leu Arg Glu Leu Leu  His Tyr Gly 
    1010                 1015                 1020             


Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ala Phe Ile  Asp Leu Phe 
    1025                 1030                 1035             


Glu Lys  His Gly Met Ile Leu  Lys Leu Lys Leu Asn  Thr Asp His 
    1040                 1045                 1050             


Gln Leu  Val Val Glu Ser Ile  Glu Pro Lys Lys Ile  Tyr His Leu 
    1055                 1060                 1065             


Gly Ser  Thr Ala Lys Asp Lys  Pro Glu Tyr Gln Tyr  Thr Thr Asn 
    1070                 1075                 1080             


Gln Val  Met Thr Val Tyr Cys  Asn Met Cys Arg Ser  Leu Leu Glu 
    1085                 1090                 1095             


Met Lys  Lys 
    1100     


<210>  157
<211>  1154
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  157

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Asn Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Glu Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Val Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Val 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Asn Phe Tyr Glu Lys Asp Val Ile Ile Lys Tyr Leu Lys Asn Thr Lys 
    530                 535                 540                 


Phe Asn Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Asn Lys Ile Asp Asp Leu Arg Asn Thr Leu Lys Phe Ser Trp 
                565                 570                 575     


Lys Ile Pro Lys Asp Lys Glu Glu Lys Asp Ala Gln Ile Tyr Leu Leu 
            580                 585                 590         


Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn Lys Phe Val Lys Asn Ser 
        595                 600                 605             


Lys Asp Phe Phe Lys Ile Thr Asp Glu Val Ile Lys Ile Asn Lys Gln 
    610                 615                 620                 


Ile Asn Gln Lys Thr Gly Tyr Tyr Lys Tyr Gln Lys Phe Glu Asn Ile 
625                 630                 635                 640 


Glu Lys Thr Val Pro Val Glu Tyr Leu Ala Ile Ile Gln Ser Arg Asp 
                645                 650                 655     


Met Ile Asn Asn Gln Asp Lys Glu Glu Lys Asn Thr Tyr Ile Asp Phe 
            660                 665                 670         


Val Gln Gln Ile Phe Leu Lys Gly Phe Ile Asp Tyr Leu Asn Lys Asn 
        675                 680                 685             


Asn Leu Lys Tyr Ile Glu Asn Asn Asn Asn Asn Asp Ile Phe Ser Arg 
    690                 695                 700                 


Ile Lys Ile Lys Lys Asp Ser Lys Glu Arg Tyr Asp Lys Ile Leu Lys 
705                 710                 715                 720 


Asn Tyr Glu Lys Asn Asn Arg Asn Lys Glu Ile Pro Tyr Glu Ile Asn 
                725                 730                 735     


Glu Phe Val Arg Glu Ile Lys Leu Gly Lys Ile Leu Lys Tyr Thr Glu 
            740                 745                 750         


Ser Leu Asn Met Phe Tyr Leu Ile Leu Lys Leu Leu Asn His Lys Glu 
        755                 760                 765             


Leu Thr Asn Leu Lys Gly Ser Leu Glu Lys Tyr Gln Ser Ala Asn Lys 
    770                 775                 780                 


Glu Glu Thr Phe Ser Asp Glu Leu Glu Leu Ile Asn Leu Leu Asn Leu 
785                 790                 795                 800 


Asp Asn Asn Arg Val Thr Glu Asp Phe Glu Leu Glu Ala Asn Glu Ile 
                805                 810                 815     


Gly Lys Phe Leu Asp Phe Asn Gly Asn Lys Ile Lys Asp Arg Lys Glu 
            820                 825                 830         


Leu Lys Lys Phe Asp Thr Lys Lys Ile Tyr Phe Asp Gly Glu Asn Ile 
        835                 840                 845             


Ile Lys His Arg Ala Phe Tyr Asn Ile Lys Lys Tyr Gly Met Leu Asn 
    850                 855                 860                 


Leu Leu Glu Lys Ile Ser Asp Glu Ala Lys Tyr Lys Ile Ser Ile Glu 
865                 870                 875                 880 


Glu Leu Lys Asn Tyr Ser Asn Lys Lys Lys Glu Ile Glu Lys Asn His 
                885                 890                 895     


Thr Thr Gln Glu Asn Leu His Arg Lys Tyr Ala Arg Pro Arg Lys Asp 
            900                 905                 910         


Glu Lys Phe Thr Asp Glu Asp Tyr Glu Ser Tyr Lys Gln Ala Ile Lys 
        915                 920                 925             


Asn Ile Glu Glu Tyr Thr His Leu Lys Asn Lys Val Glu Phe Asn Glu 
    930                 935                 940                 


Leu Asn Leu Leu Gln Gly Leu Leu Leu Arg Ile Leu His Arg Leu Val 
945                 950                 955                 960 


Gly Tyr Thr Ser Ile Trp Glu Arg Asp Leu Arg Phe Arg Leu Lys Gly 
                965                 970                 975     


Glu Phe Pro Glu Asn Gln Tyr Ile Glu Glu Ile Phe Asn Phe Glu Asn 
            980                 985                 990         


Lys Lys Asn Val Lys Tyr Lys Ser  Gly Gln Ile Val Glu  Lys Tyr Ile 
        995                 1000                 1005             


Lys Phe  Tyr Lys Glu Leu His  Gln Asn Asp Glu Val  Lys Ile Asn 
    1010                 1015                 1020             


Lys Tyr  Ser Ser Ala Asn Ile  Lys Val Leu Lys Gln  Glu Lys Lys 
    1025                 1030                 1035             


Asp Leu  Tyr Ile Arg Asn Tyr  Ile Ala His Phe Asn  Tyr Ile Pro 
    1040                 1045                 1050             


His Ala  Glu Ile Ser Leu Leu  Glu Val Leu Glu Asn  Leu Arg Lys 
    1055                 1060                 1065             


Leu Leu  Ser Tyr Asp Arg Lys  Leu Lys Asn Ala Val  Met Lys Ser 
    1070                 1075                 1080             


Val Met  Asn Ile Leu Lys Glu  Tyr Gly Phe Val Ala  Lys Phe Lys 
    1085                 1090                 1095             


Ile Gly  Ala Asp Lys Lys Ile  Gly Ile Gln Thr Leu  Glu Ser Glu 
    1100                 1105                 1110             


Lys Ile  Val His Leu Lys Asn  Leu Lys Lys Lys Lys  Leu Met Thr 
    1115                 1120                 1125             


Asp Arg  Asn Ser Glu Glu Leu  Cys Lys Leu Val Lys  Val Met Phe 
    1130                 1135                 1140             


Glu Tyr  Lys Met Glu Glu Lys  Lys Ser Glu Asn 
    1145                 1150                 


<210>  158
<211>  1427
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  158

Met Gly Asn Leu Phe Gly His Lys Arg Trp Tyr Glu Val Glu Lys Ile 
1               5                   10                  15      


Ile Lys Asp Lys Glu Val Lys Val Glu Val Arg Ile Lys Arg Lys Tyr 
            20                  25                  30          


Leu Ala Asn Glu Ser Lys Tyr Val Leu Asn Ile Asp Lys Gln Lys Glu 
        35                  40                  45              


Glu Tyr Asp Glu Asn Lys Ile Thr Asn Lys Glu Phe Val Asp Gln Phe 
    50                  55                  60                  


Ile Glu Tyr Lys Thr Lys Asn Asp Val Phe Lys Lys Phe Thr Lys Lys 
65                  70                  75                  80  


Phe His Met Gly Asn Ile Leu Phe Lys Leu Lys Ala Lys Glu Leu Thr 
                85                  90                  95      


Glu Lys Thr Ile Lys Glu Ile Arg Asn Tyr Asn Asp Phe Leu Glu Lys 
            100                 105                 110         


Glu Lys Ala Ile Leu Glu Ile Glu Ile Tyr Gln Gln Ser Glu Lys Leu 
        115                 120                 125             


Arg Glu Glu Glu Asn Ile Thr Lys Lys Asp Ile Ile Asp Lys Ala Ile 
    130                 135                 140                 


Lys Glu Lys Ile Thr Glu Asp Ser Asn Glu Ile Lys Met Gln Ile Lys 
145                 150                 155                 160 


Ser Lys Glu Asn Lys Ser Lys Glu Ile Lys Ile Ser Ile Asn Lys Glu 
                165                 170                 175     


Thr Glu Glu Tyr His Ile Lys Leu Lys Ser Ile Asn Asn Asp Glu Leu 
            180                 185                 190         


Asn Leu Lys Arg Glu Ile Tyr Glu Ile Leu Lys Ser Ile Asn Ala Asn 
        195                 200                 205             


Leu Tyr Ile Ile Thr Lys Asn Ala Ile Ser Asn Thr Asp Phe Lys Lys 
    210                 215                 220                 


Arg Asn Tyr Glu Asn Phe Leu Arg Glu Asn Ile Met Glu His Leu Lys 
225                 230                 235                 240 


Lys Asn Ile Arg Lys Lys Ser Lys Met Thr Phe Leu Lys Ser Leu Ser 
                245                 250                 255     


Asn Ser Leu Lys Lys Ile Gln Gly Asn Ile Lys Glu Asn Asp Glu Ile 
            260                 265                 270         


Ile Asn Phe Ile Lys Tyr Tyr Ser Asn Ile Asn Gly Ser Lys Thr Val 
        275                 280                 285             


Ser Glu Asn Lys Lys Asn Phe Leu Glu Lys Ile Leu Asn Thr Glu Val 
    290                 295                 300                 


Ser Val Ser Glu Asn Asp Ile Ile Asp Phe Ile Ile Gly Glu Leu Lys 
305                 310                 315                 320 


Phe Tyr Gly Ile Ile Lys Arg Ile Glu Lys Leu Gln Glu Lys Thr Ala 
                325                 330                 335     


Thr Arg Thr Asp Glu Asp Ile Lys Asn Thr Tyr Ile Asp Thr Tyr Val 
            340                 345                 350         


Ser Leu Asp Lys His Glu Lys Phe Lys Lys Tyr Asn Arg Asn Lys Lys 
        355                 360                 365             


Asp Glu Ile Val Lys Leu Phe Val Lys Asp Ile Asn Asn Asn Thr Met 
    370                 375                 380                 


Glu Glu Lys Ile Asn Gln Ile Leu Ser Lys Phe Lys Ile Glu Glu Leu 
385                 390                 395                 400 


Ile Gly Glu Leu Lys Lys Asn Thr Glu Asn Lys Asn Phe Asp Thr Glu 
                405                 410                 415     


Ile Phe Gly Ile Phe Lys Thr His Tyr Gln Lys Ile Phe Ser Ser Glu 
            420                 425                 430         


Lys Phe Glu Asn Lys Ser Asp Glu Glu Lys Glu Leu Tyr Lys Ile Ile 
        435                 440                 445             


Tyr Arg Tyr Leu Lys Gly Arg Ile Glu Lys Ile Leu Ile Asn Gly Glu 
    450                 455                 460                 


Lys Val Arg Leu Lys Lys Met Glu Lys Ile Glu Val Lys Lys Ile Phe 
465                 470                 475                 480 


Asn Glu Ser Ile Leu Ser Glu Lys Ile Leu Lys Arg Val Lys Gln Tyr 
                485                 490                 495     


Thr Leu Glu Tyr Val Met Tyr Leu Gly Lys Leu Val His Asn Asp Ile 
            500                 505                 510         


Asp Arg Ser Ile Val Asn Thr Asn Asn Phe Ser Arg Leu His Ala Arg 
        515                 520                 525             


Glu Glu Leu Asp Leu Glu Leu Ile Thr Phe Phe Ala Ser Thr Asn Met 
    530                 535                 540                 


Glu Leu Asn Lys Ile Phe Ser Arg Lys Asp Glu Tyr Glu Glu Asn Thr 
545                 550                 555                 560 


Asp Phe Phe Gly Glu Gly Ala Phe Ser Asn Lys Lys Arg Glu Lys Ile 
                565                 570                 575     


Thr Leu Asn Lys Lys Ser Leu Asn Ser Lys Ile Lys Met Ile Arg Glu 
            580                 585                 590         


Leu Asp Phe Ile Asp Asn Lys Asn Glu Ile Ile Gln Lys Asn Phe Phe 
        595                 600                 605             


Asp Lys Phe Ile Lys Ile Gly Ala Asn Glu Arg Asn Arg Ile Leu His 
    610                 615                 620                 


Ala Ser Asn Lys Arg Arg Ile Pro Gln Gly Thr Gln Asp Asp Tyr Asn 
625                 630                 635                 640 


Lys Val Ile Asn Ile Ile Gln Asn Leu Lys Ile Ser Asp Glu Glu Ala 
                645                 650                 655     


Ser Lys Ala Leu Asn Leu Asp Val Val Phe Lys Asp Lys Lys Asn Ile 
            660                 665                 670         


Ile Thr Lys Ile Asn Asp Ile Lys Ile Ser Glu Glu Asn Asn Ser Ile 
        675                 680                 685             


Ile Lys Tyr Leu Pro Ser Phe Ser Lys Val Leu Pro Glu Ile Leu Asn 
    690                 695                 700                 


Leu Tyr Lys Asn Glu Asn Lys Asn Asn Pro Phe Asp Thr Ile Glu Thr 
705                 710                 715                 720 


Glu Lys Ile Ile Gln Asn Ala Leu Ile Tyr Val Asn Lys Glu Leu Tyr 
                725                 730                 735     


Lys Lys Leu Ile Ser Glu Lys Asn Leu Glu Glu Asn Glu Ser Lys Asn 
            740                 745                 750         


Lys Phe Leu Lys Glu Leu Lys Lys Asn Leu Ser Gly Thr Asp Glu Thr 
        755                 760                 765             


Asp Glu Asn Ile Ile Glu Asn Tyr Tyr Lys Asn Ala Gln Ile Ser Ala 
    770                 775                 780                 


Ser Lys Gly Asn Asn Lys Ala Ile Lys Lys Tyr Gln Lys Lys Val Ile 
785                 790                 795                 800 


Glu Cys Tyr Ile Gly Tyr Leu Arg Lys Asn Tyr Glu Glu Leu Phe Asp 
                805                 810                 815     


Phe Ser Asp Phe Lys Met Asn Ile Gln Glu Ile Lys Lys Gln Ile Lys 
            820                 825                 830         


Asp Ile Asn Asp Asn Lys Thr Tyr Glu Arg Ile Thr Ile Lys Thr Ile 
        835                 840                 845             


Asp Lys Thr Ile Val Ile Asn Asp Asp Phe Glu Tyr Ile Ile Ser Ile 
    850                 855                 860                 


Phe Ala Leu Leu Asn Ser Asn Ala Val Ile Asn Lys Ile Arg Asn Arg 
865                 870                 875                 880 


Phe Phe Ala Thr Ser Val Trp Leu Asn Thr Ser Glu Tyr Gln Asn Ile 
                885                 890                 895     


Ile Asn Ile Leu Asp Glu Ile Met Gln Leu Asn Thr Leu Arg Asn Glu 
            900                 905                 910         


Cys Ile Thr Glu Asn Trp Asn Leu Asn Leu Glu Glu Phe Ile Gln Lys 
        915                 920                 925             


Met Lys Glu Ile Glu Lys Asp Phe Asp Asp Phe Lys Ile Gln Thr Lys 
    930                 935                 940                 


Lys Asp Ile Phe Asn Asp Asn Tyr Glu Ser Ile Lys Asn Asn Val Leu 
945                 950                 955                 960 


Ser Lys Phe Ile Gly Phe Ser Asp Val Gln Lys Ile Leu Glu Glu Lys 
                965                 970                 975     


Leu Asn Lys Leu Ile Asp Phe Glu Asn Asp Asn Glu Ile Lys Lys Ser 
            980                 985                 990         


Val Asn Ser Asp Ser Leu Asp Ser  Asp Glu Arg Arg Asn  Leu Met Pro 
        995                 1000                 1005             


Asn Ile  Asn Pro Lys Lys Gly  Gly Ile Asp Leu Ile  Arg Glu Ile 
    1010                 1015                 1020             


Asp Glu  Leu Ile Val Ile Glu  Lys Asn Asn Thr Glu  Lys Asn Ile 
    1025                 1030                 1035             


Leu Leu  Lys Ile Ile Phe Asn  Ser Asn Phe Leu Glu  Lys Tyr Lys 
    1040                 1045                 1050             


Lys Glu  Ile Asp Asn Leu Ile  Glu Gly Thr Glu Ser  Glu Asn Glu 
    1055                 1060                 1065             


Asn Lys  Phe Glu Lys Ile Tyr  Tyr Pro Glu Glu His  Lys Asn Glu 
    1070                 1075                 1080             


Leu Tyr  Ile Tyr Lys Lys Asn  Leu Phe Leu Asn Ile  Gly Asn Pro 
    1085                 1090                 1095             


Asn Phe  Asp Lys Ile Tyr Gly  Leu Ile Ser Asn Asp  Ile Lys Met 
    1100                 1105                 1110             


Ala Asp  Ala Lys Phe Leu Phe  Asn Ser Asp Gly Lys  Asn Ile Arg 
    1115                 1120                 1125             


Asn Asn  Lys Ile Val Glu Ile  Asp Val Ile Leu Lys  Lys Leu Asn 
    1130                 1135                 1140             


Asn Lys  Leu Asn Gly Tyr Ser  Lys Glu Tyr Lys Glu  Lys Tyr Val 
    1145                 1150                 1155             


Glu Lys  Leu Lys Glu Asp Asn  Asp Phe Phe Ile Lys  Asn Ile Gln 
    1160                 1165                 1170             


Asn Lys  Asn Tyr Lys Ser Phe  Lys Arg Phe Glu Glu  Asn Tyr Asn 
    1175                 1180                 1185             


Lys Val  Ser Lys Tyr Lys Lys  Ile Arg Asp Leu Val  Glu Phe Asn 
    1190                 1195                 1200             


Tyr Leu  Asn Lys Ile Glu Ser  Tyr Leu Ile Asp Ile  Asn Trp Lys 
    1205                 1210                 1215             


Leu Ala  Ile Gln Met Ala Arg  Phe Glu Arg Asp Met  His Tyr Ile 
    1220                 1225                 1230             


Val Asn  Gly Leu Asn Tyr Leu  Tyr Ile Ile Arg Leu  Glu Arg Glu 
    1235                 1240                 1245             


Ile Asn  Gln Asp Trp Ser Ser  Pro Tyr Pro Lys Tyr  Lys Tyr Ile 
    1250                 1255                 1260             


Asp Lys  Gly Asp Lys Thr Lys  Gly Arg Glu Leu Asp  Tyr Ser Thr 
    1265                 1270                 1275             


Ser Tyr  Tyr Asn Phe Lys Asp  Tyr Gln Lys Phe Val  Asp Ile Cys 
    1280                 1285                 1290             


Ser Lys  Phe Gly Ile Asp Leu  Ser Glu Asn Ser Glu  Ile Asn Lys 
    1295                 1300                 1305             


Pro Glu  Ser Glu Ser Ile Arg  Asn Tyr Ile Ser His  Phe Tyr Ile 
    1310                 1315                 1320             


Val Arg  Asn Pro Phe Ile Asp  Tyr Ser Ile Ala Glu  Gln Ile Asp 
    1325                 1330                 1335             


Arg Val  Ser Asp Leu Leu Ser  Tyr Ser Thr Arg Tyr  Asn Asn Ser 
    1340                 1345                 1350             


Thr Tyr  Ala Ser Val Phe Glu  Val Phe Lys Lys Asp  Val Asp Leu 
    1355                 1360                 1365             


Glu Tyr  Asp Glu Leu Lys Lys  Lys Phe Lys Leu Ile  Ser Asn Thr 
    1370                 1375                 1380             


Asp Ile  Leu Lys Arg Leu Met  Lys Pro Lys Lys Val  Ser Val Leu 
    1385                 1390                 1395             


Glu Leu  Glu Ser Tyr Asn Ser  Asn Tyr Ile Lys Asn  Leu Ile Ile 
    1400                 1405                 1410             


Glu Leu  Leu Thr Lys Val Glu  Asn Lys Asp Glu Ile  Ser Ser 
    1415                 1420                 1425         


<210>  159
<211>  1244
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  159

Met Lys Ile Thr Lys Ile Asp Gly Val Ser His Tyr Lys Glu Lys Glu 
1               5                   10                  15      


Lys Gly Val Leu Lys Gly Lys Asp Ile Leu Asn Gly Lys Ile Glu Lys 
            20                  25                  30          


Ile Val Lys Lys Arg Tyr Asp Ala Thr Ile Glu Ser Lys Ile Tyr Lys 
        35                  40                  45              


Glu Phe Ile Lys Leu Arg Lys Asn Arg Ile Glu Gln Asn Asn Glu Lys 
    50                  55                  60                  


Ser Ile Leu Glu Leu Ile Lys Ser Asn Ile Asp Lys Asn Glu Lys Glu 
65                  70                  75                  80  


Ile Lys Thr Leu Leu Trp Lys Asn Phe Lys Ile Lys Glu Lys Asn Lys 
                85                  90                  95      


Asn Tyr Asp Glu Tyr Ile Thr Asp Glu Ile Lys Leu Asp Asn Asp Ile 
            100                 105                 110         


Lys Ile Tyr Glu Ser Val Glu Ser Leu Tyr Phe Leu Ile Lys Glu Ile 
        115                 120                 125             


Tyr Leu Gly Gln Asn Asn Lys Lys Trp Asn Ile Ser Lys Ile Asp Leu 
    130                 135                 140                 


Glu Lys Ile Met Glu Glu Asp Ser Asp Leu Ile Met Leu Gly Tyr Lys 
145                 150                 155                 160 


Leu Lys Lys Asn Ile Lys Glu Asp Asp Tyr Pro Tyr Leu Tyr Arg Asp 
                165                 170                 175     


Lys Asn Gly Gln Glu Ser Thr Ser Val Tyr Lys Leu Leu Lys Lys Leu 
            180                 185                 190         


Ile Glu Glu Asn Lys Asp Arg Asn Gln Asp Ile Arg Lys Ser Gln Glu 
        195                 200                 205             


Tyr Glu Lys Ile Arg Lys Asn Phe Glu Glu Tyr Lys Asn Arg Lys Ile 
    210                 215                 220                 


Asn Leu Leu Val Lys Ser Ile Lys Asn Asn Lys Ile Asn Ile Gln Tyr 
225                 230                 235                 240 


Ile Asn Asn Glu Ile Lys Ser His Asp Asn Pro Arg Glu Glu Asn Ile 
                245                 250                 255     


Ile Lys Phe Phe Lys Lys Met Ile Glu Glu Lys Asn Lys Pro Ile Leu 
            260                 265                 270         


Lys Asp Lys Leu Lys Leu Phe Arg Leu Glu Val Phe Phe Asn Glu Glu 
        275                 280                 285             


Phe Leu Glu Glu Ile Lys Lys Leu Leu Asp Ser Asp Asp Ser Asp Lys 
    290                 295                 300                 


Ser Gln Asn Lys Lys Ile Ser Glu Leu Arg Gly Lys Ile Phe Asn Arg 
305                 310                 315                 320 


Ile Arg Glu Glu Ile Lys Asn Asn Lys Asn Arg Asp Glu Leu Glu Asn 
                325                 330                 335     


Ile Tyr Phe Leu Glu Leu Lys Lys Tyr Ile Glu Asn Asn Leu Ser His 
            340                 345                 350         


Lys Lys Glu Lys Asn Lys Asn Ser Asn Asn Thr Gly Glu Glu Lys Ser 
        355                 360                 365             


Lys Lys Leu Tyr Leu Lys Phe Leu Lys Lys Val Leu Phe Ile Asp Asp 
    370                 375                 380                 


Asn Asn Arg Ile Ser Ile Glu Lys Leu Lys Ser Arg Ile Asp Asp Asn 
385                 390                 395                 400 


Phe Lys Asn Leu Leu Ile Gln His Val Ile Glu Tyr Gly Lys Ile Lys 
                405                 410                 415     


Tyr Tyr Val Glu Asn Asp Asp Tyr Ile Arg Asn Ile Val Lys Asn Gly 
            420                 425                 430         


Glu Leu Lys Leu Glu Thr Lys Asp Leu Glu Tyr Ile Lys Thr Lys Glu 
        435                 440                 445             


Thr Leu Ile Arg Lys Met Ala Val Leu Val Ser Phe Ala Ala Asn Ser 
    450                 455                 460                 


Tyr Tyr Asn Leu Phe Gly Ser Ala Ser Glu Asp Ile Leu Gly Thr Glu 
465                 470                 475                 480 


Val Val Lys Asn Arg Arg Thr Asn Val Ile Lys Val Lys Ser Tyr Ile 
                485                 490                 495     


Phe Lys Glu Lys Met Leu Asn Tyr Phe Phe Asp Ser Glu Asp Phe Asp 
            500                 505                 510         


Val Asn Lys Thr Ile Glu Val Leu Glu Ser Ile Ser Tyr Ser Ile Tyr 
        515                 520                 525             


Asn Ile Arg Asn Gly Val Gly His Phe Asn Lys Leu Val Leu Gly Lys 
    530                 535                 540                 


Tyr Lys Lys Lys Asp Ile Ser Thr Asn Lys Arg Val Glu Glu Asp Leu 
545                 550                 555                 560 


Asn Asn Asn Glu Glu Ile Lys Gly Tyr Phe Ile Lys Lys Arg Gly Glu 
                565                 570                 575     


Ile Glu Lys Lys Ile Lys Glu Arg Phe Leu Ser Asn Asn Leu Gln Tyr 
            580                 585                 590         


Tyr Tyr Ala Lys Glu Arg Ile Glu Asn Tyr Phe Glu Val Tyr Glu Phe 
        595                 600                 605             


Glu Ile Leu Lys Glu Lys Ile Pro Phe Ala Pro Asn Phe Lys Arg Ile 
    610                 615                 620                 


Ile Lys Lys Gly Glu Asn Leu Leu Asn Asn Lys Lys Tyr Glu Tyr Phe 
625                 630                 635                 640 


Lys Asn Phe Asp Lys Asn Ser Val Glu Glu Lys Lys Glu Phe Leu Lys 
                645                 650                 655     


Thr Arg Asn Phe Leu Leu Lys Glu Leu Tyr Tyr Asn Asn Phe Tyr Lys 
            660                 665                 670         


Glu Phe Leu Ser Lys Lys Glu Glu Phe Lys Lys Ile Val Ile Glu Val 
        675                 680                 685             


Lys Glu Glu Lys Lys Asn Arg Gly Asn Asn Lys Lys Ser Gly Val Ser 
    690                 695                 700                 


Phe Gln Ser Ile Asp Asp Tyr Asp Thr Lys Ile Asn Ile Ser Asp Tyr 
705                 710                 715                 720 


Ile Ala Ser Ile His Lys Lys Glu Met Glu Arg Val Glu Lys Tyr Asn 
                725                 730                 735     


Glu Glu Lys Gln Lys Asp Thr Ala Lys Tyr Ile Arg Asp Phe Val Glu 
            740                 745                 750         


Glu Ile Phe Leu Thr Gly Phe Ile Asn Tyr Leu Glu Lys Asp Lys Arg 
        755                 760                 765             


Leu His Phe Leu Lys Glu Glu Phe Ser Ile Leu Cys Asn Asn Asn Asn 
    770                 775                 780                 


Val Val Asp Phe Asn Ile Asn Ile Asn Glu Glu Lys Ile Lys Glu Phe 
785                 790                 795                 800 


Leu Lys Glu Asn Asp Ser Lys Thr Leu Asn Leu Tyr Leu Phe Phe Asn 
                805                 810                 815     


Met Ile Asp Ser Lys Arg Ile Ser Glu Phe Arg Asn Glu Leu Ile Lys 
            820                 825                 830         


Tyr Lys Gln Phe Thr Lys Lys Arg Leu Asp Glu Glu Lys Glu Phe Leu 
        835                 840                 845             


Gly Ile Lys Ile Glu Leu Tyr Glu Thr Leu Ile Glu Phe Val Ile Leu 
    850                 855                 860                 


Thr Arg Glu Lys Leu Asp Thr Lys Lys Ser Glu Glu Thr Asp Ala Trp 
865                 870                 875                 880 


Leu Val Asp Lys Leu Tyr Val Lys Glu Lys Asn Glu Cys Asn Glu Tyr 
                885                 890                 895     


Glu Tyr Lys Glu Tyr Glu Glu Ile Leu Lys Leu Phe Val Asp Glu Lys 
            900                 905                 910         


Ile Leu Asn Ser Lys Glu Ala Pro Tyr Tyr Ala Thr Asn Asn Lys Thr 
        915                 920                 925             


Pro Ile Leu Leu Ser Asn Phe Glu Lys Thr Arg Lys Tyr Gly Thr Gln 
    930                 935                 940                 


Ser Phe Leu Ser Glu Ile Gln Ser Asn Tyr Lys Tyr Ser Lys Val Glu 
945                 950                 955                 960 


Lys Glu Asn Ile Glu Asp Tyr Asn Lys Lys Glu Glu Ile Glu Lys Lys 
                965                 970                 975     


Lys Lys Ser Asn Ile Glu Lys Leu Gln Asp Leu Lys Val Glu Leu His 
            980                 985                 990         


Lys Lys Trp Glu Gln Asn Lys Ile  Thr Glu Lys Glu Ile  Lys Lys Tyr 
        995                 1000                 1005             


Asn Asp  Thr Ile Lys Glu Ile  Arg Glu Tyr Asn Tyr  Leu Lys Asn 
    1010                 1015                 1020             


Lys Glu  Glu Leu Gln Asn Val  Tyr Leu Leu His Glu  Ile Leu Ser 
    1025                 1030                 1035             


Asp Leu  Leu Ala Arg Asn Val  Ala Phe Phe Asn Lys  Trp Glu Arg 
    1040                 1045                 1050             


Asp Phe  Lys Phe Ile Val Ile  Ala Ile Lys Gln Phe  Leu Arg Glu 
    1055                 1060                 1065             


Asn Asp  Lys Glu Lys Val Glu  Asn Phe Leu Asn Pro  Leu Asp Asn 
    1070                 1075                 1080             


Ser Lys  Gly Lys Lys Val Tyr  Phe Ser Val Ser Lys  Tyr Lys Asn 
    1085                 1090                 1095             


Thr Val  Glu Asn Ile Asp Gly  Ile His Lys Asn Phe  Met Asn Leu 
    1100                 1105                 1110             


Ile Phe  Leu Asn Asn Lys Phe  Met Asn Arg Lys Ile  Asp Lys Met 
    1115                 1120                 1125             


Asn Cys  Thr Ile Trp Val Tyr  Phe Arg Asn Tyr Ile  Ala His Phe 
    1130                 1135                 1140             


Leu His  Leu His Thr Lys Asn  Glu Lys Ile Ser Leu  Ile Asn Gln 
    1145                 1150                 1155             


Met Asn  Leu Leu Ile Lys Leu  Phe Ser Tyr Asp Lys  Lys Val Gln 
    1160                 1165                 1170             


Asn His  Ile Leu Lys Ser Thr  Lys Thr Leu Leu Glu  Lys Tyr Asn 
    1175                 1180                 1185             


Ile Gln  Ile Asn Phe Glu Ile  Ser Asn Asp Lys Asn  Glu Val Phe 
    1190                 1195                 1200             


Lys Tyr  Lys Ile Lys Asn Arg  Leu Tyr Ser Lys Lys  Gly Lys Met 
    1205                 1210                 1215             


Leu Gly  Lys Asn Asn Lys Phe  Glu Ile Leu Glu Asn  Glu Phe Leu 
    1220                 1225                 1230             


Glu Asn  Val Lys Ala Met Leu  Glu Tyr Ser Glu 
    1235                 1240                 


<210>  160
<211>  1118
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  160

Met Lys Leu Ile Lys Ser Asn Glu Ile Glu Lys Asp Val Ile Glu Glu 
1               5                   10                  15      


Arg Phe Ser Asn Ile Glu Ala Lys Thr Thr Glu Leu Phe Ser Lys Thr 
            20                  25                  30          


Leu Asp Phe Tyr Val Lys Asn Tyr Glu Lys Cys Glu Glu Gln Asn Lys 
        35                  40                  45              


Glu Arg Arg Glu Lys Ala Lys Asn Tyr Phe Ser Lys Val Lys Leu Ile 
    50                  55                  60                  


Val Asp Asn Lys Lys Ile Thr Ile Phe Asn Glu Asn Thr Glu Lys Ile 
65                  70                  75                  80  


Glu Ile Glu Gly Phe Asn Glu Tyr Asp Val Arg Asp Glu Lys Tyr Phe 
                85                  90                  95      


Asn Val Leu Asn Lys Ile Leu Lys Glu Glu Asn Cys Thr Glu Glu Asp 
            100                 105                 110         


Leu Glu Val Phe Glu Asn Asp Leu Gln Lys Lys Leu Asn Gln Ile Gln 
        115                 120                 125             


Ser Ile Lys Asn Ser Leu Glu Lys Asn Lys Ala His Phe Lys Lys Glu 
    130                 135                 140                 


Ser Ile Asn Asn Thr Thr Asp Arg Val Lys Gly Asn Asn Lys Lys Ser 
145                 150                 155                 160 


Leu Phe Tyr Glu Tyr Tyr Arg Asn Ser Ser Lys His Gln Glu Tyr Val 
                165                 170                 175     


Asn Asn Ile Phe Glu Ala Phe Asp Lys Leu Tyr Ser Asn Ser His Glu 
            180                 185                 190         


Asp Ile Asn Asn Leu Phe Leu Glu Ile Thr Lys Asp Ser Asn Asn Arg 
        195                 200                 205             


Asn Ile Arg Lys Ile Arg Glu Val Tyr Asn Glu Ile Leu Asn Lys Asn 
    210                 215                 220                 


Lys Thr Glu Phe Gly Glu Glu Leu Tyr Lys Lys Ile Gln Asp Asn Ile 
225                 230                 235                 240 


Ser Asn Phe Asp Lys Leu Leu Glu Ile Glu Pro Glu Ile Lys Glu Leu 
                245                 250                 255     


Thr Lys Ser Gln Ile Phe Tyr Lys Tyr Tyr Ile Asp Lys Val Ser Leu 
            260                 265                 270         


Asp Gly Thr Asn Ile Lys His Cys Phe Ser His Leu Val Glu Ile Glu 
        275                 280                 285             


Val Asn Gln Leu Leu Lys Asn Tyr Val Tyr Ser Lys Arg Ser Thr Asn 
    290                 295                 300                 


Lys Glu Lys Leu Glu Asn Ile Phe Glu Tyr Cys Lys Leu Arg Asn Leu 
305                 310                 315                 320 


Val Lys Asn Lys Leu Val Asn Lys Leu Asn Asn Tyr Ile Arg Asn Cys 
                325                 330                 335     


Gly Lys Tyr Asn Ser Tyr Ile Asn Asn Asn Asp Val Val Asn Ser Glu 
            340                 345                 350         


Lys Ile Ser Glu Ile Arg Thr Lys Glu Ala Phe Leu Arg Ser Ile Ile 
        355                 360                 365             


Gly Val Ser Ser Ser Ala Tyr Phe Ser Leu Arg Asn Ile Leu Asn Thr 
    370                 375                 380                 


Asp Asn Thr Gln Asp Ile Thr Asn Lys Val Lys Gly Glu Val Glu Lys 
385                 390                 395                 400 


Leu Tyr Gln Glu Asn Lys Lys Val Lys Leu Glu Glu Arg Leu Lys Leu 
                405                 410                 415     


Phe Phe Gly Asn Asn Phe Asp Ile Asn Asn Gln Gln Glu Ile Glu Asp 
            420                 425                 430         


Phe Leu Met Asn Ile Asp Lys Ile Ile Ser Asn Ile Arg His Glu Ile 
        435                 440                 445             


Ile His Phe Lys Ile Glu Ala Asn Ala His Ser Ile Phe Asp Phe Asn 
    450                 455                 460                 


Asn Val Thr Leu Gly Asn Lys Ala Lys Asn Ile Phe Asn Asn Glu Ile 
465                 470                 475                 480 


Asn Glu Glu Arg Ile Lys Phe Lys Ile Phe Lys Gln Leu Asn Ser Ala 
                485                 490                 495     


Asn Val Phe Asp Tyr Leu Ser Asp Glu Asn Ile Thr Glu Tyr Met Gly 
            500                 505                 510         


Lys Val Ile Phe Ser Phe Thr Asn Arg Asn Ile Pro Phe Val Pro Ser 
        515                 520                 525             


Phe Arg Lys Ile Tyr Asn Arg Val Gln Asp Leu Ala Asn Ser Leu Lys 
    530                 535                 540                 


Ile Lys Glu Trp Lys Ile Ser Asp Glu Ser Glu Gly Lys Asp Ala Gln 
545                 550                 555                 560 


Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asp Asp Phe 
                565                 570                 575     


Leu Asn Glu Lys Asn Glu Lys Phe Ile Lys Ile Lys Asp Glu Ile Ile 
            580                 585                 590         


Glu Leu Asn Lys Asn Gln Asn Lys Ile Thr Gly Phe Tyr Lys Leu Glu 
        595                 600                 605             


Lys Phe Glu Lys Ile Glu Glu Lys Asn Pro Lys Lys Tyr Leu Glu Ile 
    610                 615                 620                 


Ile Gln Ser Leu Tyr Met Ile Asn Ile Glu Glu Ile Asp Asn Glu Glu 
625                 630                 635                 640 


Lys Asn Ile Phe Leu Asp Phe Ile Gln Lys Ile Phe Leu Lys Gly Phe 
                645                 650                 655     


Phe Glu Phe Ile Lys Asn Asn Tyr Asn Tyr Leu Leu Glu Leu Lys Lys 
            660                 665                 670         


Ile Gln Asp Lys Lys Asn Ile Phe Asp Arg Glu Met Ser Glu Tyr Ile 
        675                 680                 685             


Ala Gly Glu Lys Thr Leu Glu Asp Ile Gly Glu Ile Asn Glu Ile Ile 
    690                 695                 700                 


Gln Lys Ile Glu Ile Thr Lys Ile Asp Lys Ile Leu Asn Leu Thr Asp 
705                 710                 715                 720 


Lys Ile Asn Cys Phe Tyr Leu Leu Leu Lys Leu Leu Asn Tyr Lys Glu 
                725                 730                 735     


Ile Thr Glu Leu Lys Gly Asn Leu Glu Lys Tyr Gln Ile Leu Ser Lys 
            740                 745                 750         


Thr Asp Ile Tyr Glu Lys Glu Leu Ile Leu Leu Asn Ile Val Asn Leu 
        755                 760                 765             


Asp Asn Asn Lys Val Lys Ile Glu Lys Phe Lys Ile Ser Ala Glu Glu 
    770                 775                 780                 


Ile Gly Lys Phe Ile Glu Lys Ile Ser Arg Asn Lys Lys Ile Lys Thr 
785                 790                 795                 800 


Phe Glu Glu Leu Arg Asn Phe Glu Arg Arg Glu Asn Thr Gly Glu Tyr 
                805                 810                 815     


Tyr Asn Val Tyr Ser Asp Asp Lys Asn Ile Lys Asn Ile Arg Asn Leu 
            820                 825                 830         


Tyr Asn Ile Lys Lys Tyr Gly Met Leu Asp Leu Leu Glu Arg Ile Ser 
        835                 840                 845             


Glu Lys Ser Asn Tyr Cys Ile Lys Lys Glu Asp Leu Lys Glu Tyr Asp 
    850                 855                 860                 


Lys Leu Lys Lys Lys Leu Glu Asp Lys Lys Thr Asp Phe Tyr Lys Ile 
865                 870                 875                 880 


Gln Lys Asp Leu His Tyr Lys Tyr Gln Lys Glu Tyr Lys Asn Phe Ser 
                885                 890                 895     


Lys Lys Asn Asn Thr Glu Asp Tyr Glu Lys Tyr Lys Glu Ser Ile Glu 
            900                 905                 910         


Asn Ile Glu Lys Tyr Val His Leu Lys Asn Lys Ile Glu Phe Asn Glu 
        915                 920                 925             


Leu Asn Leu Leu Gln Ser Leu Leu Leu Lys Ile Leu His Arg Leu Val 
    930                 935                 940                 


Gly Phe Thr Ser Ile Trp Glu Arg Asp Leu Arg Phe Arg Leu Ile Gly 
945                 950                 955                 960 


Glu Phe Pro Asp Glu Leu Asp Val Glu Asp Ile Phe Asp His Arg Glu 
                965                 970                 975     


Arg Tyr Arg Gly Thr Arg Gly Gln Ile Cys Lys Lys Tyr Asp Gln Phe 
            980                 985                 990         


Ile Ser Val His Ile Glu Tyr Gln  Asn Asn Lys Lys Met  Lys Asn Ile 
        995                 1000                 1005             


Lys Phe  Asp Asp Asn Asn Pro  Ile Arg Asn Tyr Ile  Ala His Phe 
    1010                 1015                 1020             


Asn Tyr  Leu Pro Thr Pro Lys  Tyr Ser Ile Leu Lys  Met Leu Gly 
    1025                 1030                 1035             


Lys Leu  Arg Glu Leu Leu Asp  Tyr Asp Arg Lys Leu  Lys Asn Ala 
    1040                 1045                 1050             


Val Met  Lys Ser Ile Lys Asp  Ile Leu Glu Glu Tyr  Gly Phe Lys 
    1055                 1060                 1065             


Ala Glu  Phe Val Ile Asn Pro  Asp Lys Glu Ile Ile  Leu Asn Ser 
    1070                 1075                 1080             


Val Lys  Ser Val Glu Ile Ile  His Leu Lys Lys Asn  Asp Leu Asn 
    1085                 1090                 1095             


Ser His  Arg Asn Ser Glu Asp  Leu Cys Lys Leu Val  Lys Ala Met 
    1100                 1105                 1110             


Leu Glu  Tyr Ser Glu 
    1115             


<210>  161
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  161

Met Lys Ile Thr Lys Ile Asp Gly Ile Leu His Lys Lys Tyr Ile Lys 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Lys Thr Asp Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Thr Ile Arg Leu Asp Thr Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Thr Leu 
    50                  55                  60                  


Lys Glu Phe Phe Ser Asn Lys Val Leu Tyr Leu Lys Asp Ser Ile Leu 
65                  70                  75                  80  


Tyr Leu Lys Asp Arg Arg Glu Lys Asn Gln Leu Gln Asn Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Leu Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Asn Asp Phe Glu Lys Lys Leu Asp Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Leu Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Ile Lys Lys Val Glu Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Phe Tyr Asn Tyr Tyr Lys Asp Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Ile Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Asn Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Thr Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Met 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asn Val Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asn Lys Glu Lys Leu Asn Asp Glu 
        275                 280                 285             


Asn Ile Lys Tyr Val Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Ser Phe Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Val Gly Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Thr Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Ile Lys Gly Lys Thr Val Lys Asn Lys 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Ile Ser Gly Glu Ile Asp Lys Leu Tyr Asp 
            420                 425                 430         


Asn Asn Lys Gln Asn Glu Val Lys Lys Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asn Arg Lys Lys Glu Ile Glu Asp Phe Phe Ser 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Thr Phe Lys Asn Ile Val 
                485                 490                 495     


Pro Ser Gln Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Asn Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Cys Ile Tyr Trp 
                565                 570                 575     


Lys Ile Pro Lys Ala Asn Asp Asn Asn Lys Thr Lys Glu Ile Thr Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ile Lys Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asn Leu Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Phe Tyr Met Ile Asp Ala Gly Asn Lys Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Ala Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Met 
    690                 695                 700                 


Tyr Ile Gly Asn Asp Glu Gln Ile Asn Thr Ser Leu Ala Gly Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Lys Ile Leu Lys Tyr Thr Glu Ser Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Ala Phe Ser Asp Gln Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Val Lys Asp Asn Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Ile Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Ile Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Asn Asp Glu Asp Tyr Lys 
        915                 920                 925             


Lys Tyr Glu Lys Thr Ile Arg Asn Ile Gln Gln Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Ser Leu Leu Leu 
945                 950                 955                 960 


Arg Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Asn Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Ser Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asp  Met Glu Lys Ile Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Glu Leu  Lys Lys Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  Asn Ala Glu Val Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Ile Met Lys Ser  Ile Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Val Thr Phe Lys  Ile Glu Lys Asp Lys  Lys Ile Arg 
    1100                 1105                 1110             


Ile Glu  Ser Leu Lys Ser Glu  Glu Val Val His Leu  Lys Lys Leu 
    1115                 1120                 1125             


Lys Leu  Lys Asp Asn Asp Lys  Lys Lys Glu Pro Ile  Lys Thr Tyr 
    1130                 1135                 1140             


Arg Asn  Ser Lys Glu Leu Cys  Lys Leu Val Lys Val  Met Phe Glu 
    1145                 1150                 1155             


Tyr Lys  Met Lys Glu Lys Lys  Ser Glu Asn 
    1160                 1165             


<210>  162
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  162

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Asp Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Thr 
        115                 120                 125             


Lys Asp Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His 
            180                 185                 190         


Glu Arg Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Glu Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Arg 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Lys 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Thr Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Phe Asp Phe Lys Leu  Leu Asn 
    1370                 1375                 1380         


<210>  163
<211>  1101
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  163

Met Arg Ile Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Ile Tyr Ser Glu 
            20                  25                  30          


Gln Ala Val Ser Asn Glu Thr Asn Asn Ile Leu Pro Val Lys Lys Met 
        35                  40                  45              


Asp Ser Phe Asn Leu Ser Ile Leu Asn Lys Thr Ile Ile Lys Phe Glu 
    50                  55                  60                  


Thr Val Lys Lys Gln Lys Leu Asn Leu Asp Gln Tyr Lys Ile Val Glu 
65                  70                  75                  80  


Lys Ile Phe Lys Tyr Pro Lys Gln Glu Leu Pro Lys Gln Ile Asn Ala 
                85                  90                  95      


Glu Glu Ile Leu Gln Phe Leu Asn His Lys Phe Gln Glu Pro Val Lys 
            100                 105                 110         


Tyr Trp Lys Asn Gly Lys Glu Glu Ser Phe Asn Leu Thr Leu Leu Ile 
        115                 120                 125             


Val Glu Ala Val Lys Thr Gln Glu Lys Arg Lys Leu Gln Pro Tyr Tyr 
    130                 135                 140                 


Asp Trp Lys Thr Trp Tyr Ile Gln Thr Lys Ser Asp Leu Leu Lys Lys 
145                 150                 155                 160 


Ser Ile Glu Asn Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg 
                165                 170                 175     


Lys Lys Ala Leu Leu Ala Trp Glu Thr Glu Phe Thr Thr Ser Gly Ser 
            180                 185                 190         


Ile Asp Leu Thr His Phe His Lys Val Tyr Met Thr Asp Val Leu Cys 
        195                 200                 205             


Thr Ala Leu Gln Lys Val Glu Pro Ser Ala Asp Glu Arg Gly Lys Met 
    210                 215                 220                 


Asn Ser Asn Ala Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Asn His 
225                 230                 235                 240 


Gln Pro Ala Ile Phe Gly Thr Arg Glu Ala Pro Asn Glu Val Asn Arg 
                245                 250                 255     


Ala Asp Asn Gln Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu 
            260                 265                 270         


Glu His Tyr Phe Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Ala Asp 
        275                 280                 285             


Asp Ile Ser His Tyr Leu Lys Ala Gln Thr Leu Lys Thr Thr Ile Glu 
    290                 295                 300                 


Lys Gln Leu Val Asn Ala Ile Arg Ala Asn Ile Ile Gln Gln Gly Lys 
305                 310                 315                 320 


Thr Asn His His Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile 
                325                 330                 335     


Arg Ile Lys Thr Asn Glu Ala Phe Val Leu Asn Leu Ile Gly Thr Cys 
            340                 345                 350         


Ala Phe Ala Ala Asn Asn Ile Arg Asn Met Val Asp Lys Glu Gln Ile 
        355                 360                 365             


Ser Asp Ile Leu Gly Lys Arg Glu Phe Ile Asp Ser Leu Thr Lys Ser 
    370                 375                 380                 


Arg Ile Ser Ser Gln Leu Tyr Ser Phe Phe Phe Gly Glu Asn Leu Ser 
385                 390                 395                 400 


Thr Asn Lys Ala Glu Lys Glu Thr Gln Leu Trp Gly Ile Arg Gly Ala 
                405                 410                 415     


Val Gln Gln Ile Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu 
            420                 425                 430         


Thr Thr Ile Phe Asn Ile Cys Lys Phe Glu Asn Pro Thr Asp Ala Asp 
        435                 440                 445             


Pro Lys Gln Gln Thr Asn Tyr Val Asp Ser Ile Tyr Lys Thr Leu Phe 
    450                 455                 460                 


Ile Lys Glu Leu Glu Lys Ile Pro Glu Ala Phe Ala Gln Gln Leu Lys 
465                 470                 475                 480 


Thr Gly Gly Ala Leu Ser Tyr Tyr Thr Val Glu Asn Leu Lys Thr Leu 
                485                 490                 495     


Leu Thr Thr Phe Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala 
            500                 505                 510         


Pro Gly Phe Lys Lys Val Leu Asn Gly Gly Ile Asn Tyr Gln Asn Ala 
        515                 520                 525             


Lys Gln Asp Glu Ser Phe Tyr Glu Leu Met Leu Glu Arg Tyr Leu Arg 
    530                 535                 540                 


Lys Glu Asn Phe Ala Glu Glu Ala Tyr Asn Ala Arg Tyr Phe Leu Leu 
545                 550                 555                 560 


Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Lys Phe Thr Ala Asp Arg 
                565                 570                 575     


Lys Ala Phe Ala Asp Ser Val Gly Phe Val Gln Leu Gln Asn Arg Lys 
            580                 585                 590         


Gln Ala Glu Asn Ser Lys Arg Pro Lys Ala Phe Ala Phe Glu Ala Val 
        595                 600                 605             


Arg Pro Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala Tyr Val 
    610                 615                 620                 


Gln Ser Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys Ala Thr 
625                 630                 635                 640 


Asp Glu Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val Phe Ile 
                645                 650                 655     


Lys Gly Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe Val Gln 
            660                 665                 670         


Val Pro Gln Pro Gln Leu Thr Thr Thr Asp Ser Asn Gln Gln Lys Ala 
        675                 680                 685             


Asp Lys Leu Asn Gln Leu Glu Ala Ser Ile Thr Ala Asp Cys Lys Leu 
    690                 695                 700                 


Thr Ala Gln Tyr Ala Lys Thr Asp Asp Ala Thr His Ile Ala Phe Tyr 
705                 710                 715                 720 


Val Phe Cys Lys Leu Leu Asp Ala Gly His Leu Ser Asn Leu Arg Asn 
                725                 730                 735     


Glu Leu Ile Lys Phe Arg Gly Ser Val Lys Asp Phe Asp Phe His His 
            740                 745                 750         


Leu Leu Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val Val Pro 
        755                 760                 765             


Thr Asp Tyr Arg Asp Leu Tyr Ser Ser Gly Ala Asp Cys Leu Ala Arg 
    770                 775                 780                 


Leu Arg Pro Phe Ile Glu Gln Gly Ala Asp Ile Lys Asn Trp Ser Asp 
785                 790                 795                 800 


Leu Tyr Val Gln Thr Asp Lys Gln Thr Pro Val Ile His Ala Gly Ile 
                805                 810                 815     


Glu Leu Ser Val Lys Tyr Gly Thr Thr Ala Leu Leu Glu Gln Leu Ile 
            820                 825                 830         


Thr Cys Asn Pro Lys Phe Arg Val Met Glu Asp Asn Phe Thr Lys Trp 
        835                 840                 845             


Ser Ala Gln Lys Lys Glu Ile Glu Glu Lys Val Asn Lys His Thr Asn 
    850                 855                 860                 


Leu His Gln Gln Trp Val Glu Ala Lys Glu Lys Asp Asp Arg Glu Arg 
865                 870                 875                 880 


Val Lys Ser Lys Lys Asn Phe Val Arg Glu Tyr Val Lys Lys Asn Tyr 
                885                 890                 895     


Val Asp Tyr Ile Asn Asn Cys Ile Glu Ile Asn Asn Tyr Asn Trp Leu 
            900                 905                 910         


Asp Asn Lys Leu His Phe Val His Leu Asn His Leu His His Leu Thr 
        915                 920                 925             


Ile Asp Ile Leu Gly Arg Met Ala Gly Phe Val Ala Leu Trp Glu Arg 
    930                 935                 940                 


Asp Phe Gln Tyr Ile Thr Lys Tyr Thr Ala Ala Lys Glu Gly Thr Asp 
945                 950                 955                 960 


Ala Leu Ser Phe Asp Gly Gly Leu Pro Arg Leu Lys Asp Lys Gln Glu 
                965                 970                 975     


Tyr Tyr Asn Lys Leu Phe Leu Ser Asp Lys Tyr Thr Lys Val Arg Asn 
            980                 985                 990         


His Ile Ala His Phe Asn Tyr Leu  Thr Lys Asp Ala Ala  Asp Phe Ala 
        995                 1000                 1005             


Leu Leu  Asp Leu Ile Asn Glu  Leu Arg Glu Leu Leu  His Tyr Gly 
    1010                 1015                 1020             


Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ala Phe Ile  Asp Leu Phe 
    1025                 1030                 1035             


Glu Lys  His Gly Met Ile Leu  Lys Leu Lys Leu Asn  Thr Asp His 
    1040                 1045                 1050             


Gln Leu  Val Val Glu Ser Ile  Glu Pro Lys Lys Ile  Tyr His Leu 
    1055                 1060                 1065             


Gly Ser  Thr Ala Lys Asp Lys  Pro Glu Tyr Gln Tyr  Thr Thr Asn 
    1070                 1075                 1080             


Gln Val  Met Thr Val Tyr Cys  Asn Met Cys Arg Ser  Leu Leu Glu 
    1085                 1090                 1095             


Met Lys  Lys 
    1100     


<210>  164
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  164

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Asp Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Thr 
        115                 120                 125             


Lys Asp Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His 
            180                 185                 190         


Glu Arg Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Glu Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Arg 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Lys 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Thr Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Phe Asp Phe Lys Leu  Leu Asn 
    1370                 1375                 1380         


<210>  165
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  165

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Asp Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Thr 
        115                 120                 125             


Lys Asp Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His 
            180                 185                 190         


Glu Arg Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Glu Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Arg 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Lys 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Thr Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Phe Asp Phe Lys Leu  Leu Asn 
    1370                 1375                 1380         


<210>  166
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  166

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Asp Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn Tyr Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Gly Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Gly Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Lys Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Arg Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Asp Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  167
<211>  1268
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  167

Met Lys Val Ser Lys Val Lys His Arg Arg Thr Ala Val Ser Val Asn 
1               5                   10                  15      


Lys Lys Asn Asn Thr Val Lys Gly Ile Leu Tyr Asp Asp Pro Ile Lys 
            20                  25                  30          


Lys Asp Ser Lys Gly Asp Gly Ala Ser Ala Tyr Val Ser Thr Lys Tyr 
        35                  40                  45              


Val Val Asp Asp Val Val Arg Asn Ser Ser Arg Leu Tyr Ser Pro Phe 
    50                  55                  60                  


Asn Ser Lys Lys Leu Ile Ile Asp Asp Lys Thr Lys Val Val Ala Asn 
65                  70                  75                  80  


Ser Leu Arg Gln His Phe Lys Asn Phe Val Lys Ile Tyr Leu Asn Cys 
                85                  90                  95      


Glu Ser Ile Asp Glu Gln Gln Met Lys Phe Thr Pro Asp Asn Lys Tyr 
            100                 105                 110         


Leu Met Asp Asn Arg Val Arg Ile Ser Leu Pro Ser Asp Val Asn Glu 
        115                 120                 125             


Glu Lys Leu Val Glu Ala Ile Val Asn Ser Ser Leu Arg Lys Ser Leu 
    130                 135                 140                 


Asn Lys Lys Cys Asn Ile Gln Ile Lys Ala Gly Leu Arg Glu Thr Phe 
145                 150                 155                 160 


Asp Ile Pro Glu Leu Ile Lys Lys Ala Ile Lys Ile Tyr Cys Ile Asp 
                165                 170                 175     


Glu Lys Arg Asn Leu Asn Asp Ala Glu Lys Leu Asp Met Tyr Ala Leu 
            180                 185                 190         


Phe Ser Phe Met Tyr Glu Asp Lys Tyr Lys Asn Arg Gln Lys Lys Leu 
        195                 200                 205             


Ile Ile Asn Ser Ile Ser Asn Gln Val Thr Lys Val Lys Val Cys Glu 
    210                 215                 220                 


Asn Gly Asn Arg Leu Leu Lys Leu Ser Ile Ala Asp Thr Lys Lys Lys 
225                 230                 235                 240 


Pro Leu Trp Asp Phe Met Ile Glu Tyr Ser Asn Ser Asp Lys Lys Lys 
                245                 250                 255     


Gln Asp Thr Met Leu Arg Asn Ile Arg Lys Ser Ile Val Leu Phe Val 
            260                 265                 270         


Cys Gly Val Glu Asn Tyr Lys Asn Ile Glu Asn Asp Asn Lys Leu Asp 
        275                 280                 285             


Ile Cys Ser Trp Asp Gly Tyr Asp Ile Asn Glu Asn Gln Gln Phe Val 
    290                 295                 300                 


Cys Val Asn Thr Asn Asn Ser Asn Asp Asp Tyr Phe Ile Ser Ser Thr 
305                 310                 315                 320 


Glu Leu Arg Arg Ala Asn Leu Asp His Tyr Met Lys Ala Val Ala Lys 
                325                 330                 335     


Leu Asn Asp Asp Arg Asn Lys Phe Trp Phe Gln His Phe Glu Ser Val 
            340                 345                 350         


Ile Glu Thr Phe Phe Ser Lys Lys Ala Lys Arg Asn Ile Glu Arg Ile 
        355                 360                 365             


Lys Ser Ala Tyr Leu Cys Glu Tyr Leu Trp Arg Asp Phe Cys Ser Tyr 
    370                 375                 380                 


Val Ala Leu Lys Tyr Val Asp Leu Gly Lys Gly Val Tyr His Phe Thr 
385                 390                 395                 400 


Met Ala Asp Lys Leu Ala Leu Ile Asn Arg Asn Lys Tyr Glu Lys Ser 
                405                 410                 415     


Ile Ile Phe Gly Glu Ile Glu Ser Arg Tyr Asn Asn Gly Ile Ser Ser 
            420                 425                 430         


Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Leu Phe Glu Arg Asn Ile 
        435                 440                 445             


Ser Thr Tyr Thr Thr Phe Ala Thr Asn Ile Phe Ser Lys Ala Val Val 
    450                 455                 460                 


Gln Asp Asp Tyr Ile Lys Asn His Asn Lys Ala Ser Asp Val Leu Gln 
465                 470                 475                 480 


Tyr Ser Asp Lys Glu Phe Ser Asp Ser Lys Val Leu Arg Asn Asp Ala 
                485                 490                 495     


Met Lys Arg Ile Leu Gln Tyr Trp Gly Gly Gln Ser Arg Trp Asn Asn 
            500                 505                 510         


Thr Leu Asn Lys Ile Asn Val Asp Thr Leu Cys Ile Asp Ile Lys Glu 
        515                 520                 525             


His Leu Ser Asn Ile Arg Asn Ser Ser Val His Tyr Thr Ser Lys Val 
    530                 535                 540                 


Ser Leu Ser Gly Asp Lys Asn Glu Ser Ile Val Tyr Met Leu Phe Lys 
545                 550                 555                 560 


Lys Asp Phe Ala Glu Ile Arg Asn Ile Phe Ala Ser Lys Tyr Tyr Ser 
                565                 570                 575     


Asn Asn Val Trp Met Phe Tyr Ser Ile Glu Lys Ile Asn Gly Leu Met 
            580                 585                 590         


Glu Tyr Leu Tyr Gly Asp Asn Ser Thr Val Ile Asp Ala Gln Ile Pro 
        595                 600                 605             


Ala Tyr Asn Asn Ile Ile Lys Arg Lys Asn Ile Ala Asp Val Ile Glu 
    610                 615                 620                 


Lys Ile Ile Lys Lys Asn Ser Tyr Lys Thr Ile Asn Glu Leu Glu Leu 
625                 630                 635                 640 


Ile Lys Lys Tyr Arg Ala Cys Leu Tyr Phe Ile Leu Lys Glu Ile Tyr 
                645                 650                 655     


Tyr Asn Arg Phe Ile Lys Gln Glu Asn Leu Lys Glu Gln Phe Ile Gln 
            660                 665                 670         


Phe Val Asp Asn Asp Asn Asn Leu Leu Asp Asp Asn Lys Asn Ala Val 
        675                 680                 685             


Glu Ser Phe Arg Arg Arg Ile His Asp Ile Asp Asn Ser Leu Met Ser 
    690                 695                 700                 


Phe Gly Glu Met Cys Gln Phe Ile Met Thr Asp Tyr Asn Met Gln Asn 
705                 710                 715                 720 


Gln Gly Asn Lys Ser Ile Lys Ser Lys Asp Arg Gln Asn Glu Asp Lys 
                725                 730                 735     


Lys Lys Gly Ile Asp Gly Ser Tyr Lys His Phe Pro Leu Leu Leu Tyr 
            740                 745                 750         


His Val Ile Lys Glu Leu Phe Leu Lys Tyr Ile Lys Thr Asp Glu Lys 
        755                 760                 765             


Ile Val Phe Ile Arg Glu Pro Ala Asn Ile Gly Ser Val Lys Thr Gln 
    770                 775                 780                 


Asp Glu Phe Glu Thr His Ile Ser Thr Leu Gly Leu Tyr Lys Thr Leu 
785                 790                 795                 800 


Lys Glu Lys Val Asp Ser Asn Met Ser Leu Leu Asp Trp Tyr Thr Leu 
                805                 810                 815     


Ser His Phe Leu Met Pro Lys Gln Leu Asn Tyr Leu Ile Gly Asp Ile 
            820                 825                 830         


Lys Asn Tyr Ile Gln Tyr Leu Arg Asn Ile Asp Lys Arg Ala Glu Ser 
        835                 840                 845             


Val Gly Asn Asn Lys Ala Tyr Asp Ile Asp Gly Lys Ile Asn Asn Tyr 
    850                 855                 860                 


Tyr Asp Ile Val Tyr Val Leu Asp Phe Ser Leu Gln Tyr Ile Gly Arg 
865                 870                 875                 880 


Ile Ser Asn Glu Ile Thr Asp Tyr Phe Ala Asp Glu Asp Glu Tyr Ala 
                885                 890                 895     


Leu Phe Met Ser Gln Phe Val Asp Phe Ser Ser Asp Asn Ile Val Gly 
            900                 905                 910         


Leu Lys Thr Phe Cys Asn Glu Lys Thr Ser Asn Gly Lys His Thr Ile 
        915                 920                 925             


Gly Leu Tyr Cys Asp Gly Ala Asn Pro Ile Met Asn Arg Asn Ile Ala 
    930                 935                 940                 


Tyr Ala Lys Met Tyr Ser Asn Asp Lys Ile Leu Ser Arg Thr Tyr Ser 
945                 950                 955                 960 


Lys Val Thr Ile Lys Glu Ile Glu Arg Tyr Tyr Arg Ile Gln Asp Asp 
                965                 970                 975     


Leu Lys Asn Val Phe Glu Asn Gly Val Cys Lys Asn Lys Asp Gln Gln 
            980                 985                 990         


Lys Glu Leu Cys Asp Phe Gln Lys  Ile Lys Asn His Ile  Glu Leu Thr 
        995                 1000                 1005             


Glu Ile  Ser Ile Tyr Thr Asn  Ile Leu Asn Asp Phe  Met Ser Gln 
    1010                 1015                 1020             


Phe Ile  Ser Trp Ser Tyr Leu  Arg Glu Arg Asp Leu  Met Tyr Phe 
    1025                 1030                 1035             


Gln Leu  Gly Met His Tyr Leu  Arg Leu Tyr Tyr Gly  Thr Asn Glu 
    1040                 1045                 1050             


Leu Glu  Thr Lys Tyr Asn Lys  Leu Val Gly Glu Ser  Val Asn Ile 
    1055                 1060                 1065             


Glu Lys  Gly Ala Leu Leu Tyr  Gln Ile Ala Ala Met  Tyr Thr Tyr 
    1070                 1075                 1080             


Lys Leu  Pro Ile Tyr Lys Val  Asp Lys Asn Gly Ser  Ala Val Leu 
    1085                 1090                 1095             


Ala Glu  Lys Gln Gly Gly Thr  Gly Ala Ser Val Thr  Ser Phe Val 
    1100                 1105                 1110             


Thr Glu  Tyr Cys Lys Glu Asn  Met Arg Asp Ala Ile  Ile Tyr Glu 
    1115                 1120                 1125             


Lys Gly  Leu Glu Leu Phe Glu  Asp Val Lys Gln His  Lys Lys Trp 
    1130                 1135                 1140             


Ser Asp  Phe Arg Asn Asp Ile  Ala His Met Arg Tyr  Ile Ser Asp 
    1145                 1150                 1155             


Arg Asp  Lys Ser Ile Met Asp  Ile Ile Ser Glu Ile  Tyr Gly Gly 
    1160                 1165                 1170             


Phe Phe  Thr Tyr Asp Ile Lys  Leu Lys Lys Ser Ile  Pro Val Ile 
    1175                 1180                 1185             


Phe Lys  Asn Ile Leu Met Arg  Tyr Ala Val Asp Ala  Asn Leu Asn 
    1190                 1195                 1200             


Phe Leu  His Lys Glu Asn Arg  Lys Leu Lys Asp Thr  Leu Ile Asn 
    1205                 1210                 1215             


Ile Arg  Ala Asp Lys Gly Leu  Val Ser Asp Lys Tyr  Thr Tyr Lys 
    1220                 1225                 1230             


Ile Gly  Glu Lys Asp Thr Val  Asp Ile Glu Val Arg  Asn Asp Lys 
    1235                 1240                 1245             


Phe Leu  Leu Gln Leu Arg Lys  Leu Leu Glu Tyr Lys  Ile Arg Val 
    1250                 1255                 1260             


Asn Gly  Asn Val Leu 
    1265             


<210>  168
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  168

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Asp Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Thr 
        115                 120                 125             


Lys Asp Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His 
            180                 185                 190         


Glu Arg Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Glu Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Arg 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Lys Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  169
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  169

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  170
<211>  1435
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  170

Leu Phe Leu Trp Ile Ile Glu Glu Val Ile Tyr Glu Ile Ile Lys Leu 
1               5                   10                  15      


Tyr Lys Asn Leu Glu Glu Glu Ile Ile Met Gly Asn Leu Phe Gly Tyr 
            20                  25                  30          


Lys Arg Trp Tyr Glu Val Arg Asp Lys Glu Asp Tyr Lys Ile Lys Arg 
        35                  40                  45              


Lys Val Lys Val Lys Arg Asn Tyr Asp Gly Asn Lys Tyr Ile Leu Asn 
    50                  55                  60                  


Ile Asn Glu Asn Asn Asn Lys Glu Lys Ile Asp Asp Asn Lys Phe Ile 
65                  70                  75                  80  


Arg Glu Phe Ile Asn Tyr Lys Lys Asn Asp Asn Val Leu Arg Glu Phe 
                85                  90                  95      


Lys Lys Lys Phe His Ala Gly Asn Ile Leu Phe Lys Leu Lys Gly Lys 
            100                 105                 110         


Glu Lys Ile Arg Arg Ile Glu Asn Asp Asp Asp Phe Leu Glu Thr Glu 
        115                 120                 125             


Glu Val Val Leu Tyr Ile Glu Val Tyr Gly Gln Ser Glu Lys Leu Lys 
    130                 135                 140                 


Asn Glu Glu Glu Ile Thr Lys Lys Asp Ile Leu Lys Glu Ile Asn Lys 
145                 150                 155                 160 


Gln Lys Ile Asp Asn Ser Val Lys Lys Ile Ser Met Asn Thr Asn Ser 
                165                 170                 175     


Gly Lys Thr Ile Val Ile Asn Phe Ser Asp Lys Leu Lys Lys Asp Lys 
            180                 185                 190         


Asp Asp Tyr Gln Ile Thr Leu Asn Ile Ile Ser Glu Asp Glu Leu Glu 
        195                 200                 205             


Arg Lys Arg Lys Ile Tyr Asp Ile Phe Lys Met Ile Asn Met Asp Leu 
    210                 215                 220                 


Tyr Gln Ile Ile Lys Glu Ile Ile Glu Asn Glu Val Gln Lys Val Phe 
225                 230                 235                 240 


Glu Asn Arg Tyr Tyr Glu Glu Tyr Leu Arg Glu Lys Leu Leu Lys Asp 
                245                 250                 255     


Asp Lys Ile Asp Val Ile Leu Thr Asn Phe Met Glu Ile Arg Glu Lys 
            260                 265                 270         


Ile Lys Ser Asn Leu Glu Ile Met Gly Phe Val Lys Phe Tyr Leu Asn 
        275                 280                 285             


Val Gly Gly Asp Lys Lys Lys Ser Glu Asn Lys Lys Met Phe Val Glu 
    290                 295                 300                 


Lys Ile Leu Asn Ile Asn Val Asp Leu Thr Val Glu Asp Ile Val Asp 
305                 310                 315                 320 


Phe Ile Val Lys Glu Leu Lys Phe Trp Asn Ile Thr Lys Arg Ile Glu 
                325                 330                 335     


Lys Val Lys Glu Phe Asn Asn Lys Phe Leu Glu Asn Lys Arg Asn Arg 
            340                 345                 350         


Thr Tyr Ile Lys Ser Tyr Val Leu Leu Asp Lys His Glu Lys Phe Lys 
        355                 360                 365             


Ile Glu Arg Glu Asn Lys Lys Asp Lys Ile Val Lys Phe Phe Val Glu 
    370                 375                 380                 


Asn Ile Lys Asn Asn Ser Ile Lys Glu Lys Ile Glu Lys Ile Leu Ala 
385                 390                 395                 400 


Glu Phe Lys Ile Asp Glu Leu Thr Lys Lys Leu Glu Lys Glu Leu Lys 
                405                 410                 415     


Lys Gly Asn Cys Asp Thr Glu Ile Phe Gly Ile Phe Lys Lys His Tyr 
            420                 425                 430         


Lys Val Asn Phe Asp Ser Lys Lys Phe Ser Asn Lys Ser Asp Glu Glu 
        435                 440                 445             


Lys Glu Leu Tyr Lys Ile Ile Tyr Arg Tyr Leu Lys Gly Arg Ile Glu 
    450                 455                 460                 


Lys Ile Leu Ile Asn Gly Glu Lys Val Arg Leu Lys Lys Met Glu Lys 
465                 470                 475                 480 


Ile Glu Ile Glu Lys Ile Leu Asn Glu Ser Ile Leu Ser Glu Lys Ile 
                485                 490                 495     


Leu Lys Arg Ile Lys Gln Tyr Thr Leu Glu His Ile Met Tyr Leu Gly 
            500                 505                 510         


Lys Leu Val His Asn Lys Ile Asn Met Ala Thr Val Asn Thr Asn Asp 
        515                 520                 525             


Phe Phe Arg Leu His Ala Lys Glu Glu Leu Asp Leu Glu Leu Ile Thr 
    530                 535                 540                 


Phe Phe Ala Ser Thr Asn Met Glu Leu Asn Lys Ile Phe Ser Arg Glu 
545                 550                 555                 560 


Asn Ile Asn Asn Asp Glu Asn Ile Asp Phe Phe Gly Gly Asp Arg Glu 
                565                 570                 575     


Lys Asn Tyr Val Ile Asp Lys Lys Asn Leu Asn Ser Lys Ile Lys Ile 
            580                 585                 590         


Ile Arg Asp Leu Asp Phe Ile Asp Asn Lys Asn Asn Ile Thr Asn Asp 
        595                 600                 605             


Phe Ile Asn Lys Phe Thr Lys Ile Gly Thr Asn Glu Arg Asn Arg Ile 
    610                 615                 620                 


Leu His Ala Ser Gly Lys Lys Arg Asp Ser Gln Gly Thr Gln Asp Asp 
625                 630                 635                 640 


Tyr Asn Lys Val Ile Asn Ile Ile Gln Asn Leu Lys Ile Ser Asp Glu 
                645                 650                 655     


Glu Val Ser Lys Ala Leu Asn Leu Asp Val Val Phe Lys Asp Lys Lys 
            660                 665                 670         


Asn Ile Ile Thr Glu Ile Asn Asp Ile Lys Ile Ser Glu Glu Asn Ser 
        675                 680                 685             


Asn Asp Ile Lys Tyr Leu Pro Ser Phe Ser Lys Val Leu Pro Glu Ile 
    690                 695                 700                 


Leu Asn Leu Tyr Arg Asn Asn Pro Lys Asn Lys Pro Phe Asp Thr Ile 
705                 710                 715                 720 


Glu Thr Glu Lys Ile Val Leu Asn Ala Leu Ile Tyr Val Asn Lys Glu 
                725                 730                 735     


Leu Tyr Lys Lys Leu Ile Leu Glu Asp Asp Leu Lys Lys Asn Arg Ser 
            740                 745                 750         


Glu Asn Ile Phe Leu Gln Glu Leu Lys Lys Thr Leu Gly Asn Ile Asp 
        755                 760                 765             


Glu Thr Asp Glu Asn Ile Ile Glu Asn Tyr Tyr Lys Asn Ala Gln Ile 
    770                 775                 780                 


Ser Ala Ser Lys Gly Asn Asn Lys Val Ile Lys Lys Tyr Gln Lys Lys 
785                 790                 795                 800 


Val Ile Glu Cys Tyr Ile Gly Tyr Leu Arg Lys Asn Tyr Glu Lys Leu 
                805                 810                 815     


Phe Asp Phe Ser Asp Phe Lys Met Asn Ile Gln Glu Ile Lys Lys Gln 
            820                 825                 830         


Ile Lys Asp Ile Asn Asp Asn Lys Thr Tyr Glu Arg Ile Thr Ile Lys 
        835                 840                 845             


Thr Ser Asp Lys Ser Ile Val Ile Asn Asp Asp Phe Glu Tyr Ile Ile 
    850                 855                 860                 


Ser Ile Phe Ala Leu Leu Asn Ser Asn Thr Ile Ile Asn Lys Ile Arg 
865                 870                 875                 880 


Asn Arg Phe Phe Ala Thr Ser Val Trp Leu Glu Lys Gln Asn Ser Thr 
                885                 890                 895     


Lys Glu Tyr Asp Tyr Glu Asn Ile Ile Ser Ile Leu Asp Glu Ile Met 
            900                 905                 910         


Gln Leu Asn Thr Leu Arg Asn Glu Cys Ile Thr Glu Asn Trp Asn Leu 
        915                 920                 925             


Asn Leu Glu Glu Phe Ile Gln Lys Met Lys Asp Ile Glu Lys Glu Phe 
    930                 935                 940                 


Glu Asp Phe Lys Ile Gln Thr Lys Lys Asp Ile Phe Asn Ser Asn Tyr 
945                 950                 955                 960 


Glu Gly Ile Lys Asn Asn Val Leu Asn Lys Phe Ile Gly Phe Ser Asp 
                965                 970                 975     


Val Gln Lys Ile Leu Glu Glu Lys Leu Asn Lys Leu Ile Glu Phe Glu 
            980                 985                 990         


Asn Asp Asn Glu Ile Lys Lys Ser  Val Asn Leu Asp Ser  Leu Asp Ser 
        995                 1000                 1005             


Asp Glu  Arg Arg Lys Leu Met  Pro Asn Ile Asn Pro  Lys Lys Gly 
    1010                 1015                 1020             


Gly Ile  Asp Leu Ile Lys Glu  Ile Asp Lys Leu Ile  Met Ile Glu 
    1025                 1030                 1035             


Lys Asn  Asn Ile Glu Lys Asn  Ile Leu Leu Lys Ile  Ile Phe Asn 
    1040                 1045                 1050             


Ser Asp  Phe Leu Glu Lys Tyr  Lys Glu Glu Ile Asp  Asn Leu Val 
    1055                 1060                 1065             


Glu Cys  Thr Glu Ser Lys Asn  Glu Asn Lys Phe Glu  Lys Ile Tyr 
    1070                 1075                 1080             


Tyr Pro  Glu Glu His Lys Asn  Glu Leu Tyr Ile Tyr  Lys Lys Asn 
    1085                 1090                 1095             


Leu Phe  Leu Asn Ile Gly Asn  Pro Asn Phe Asp Lys  Ile Tyr Glu 
    1100                 1105                 1110             


Leu Ile  Ser Lys Asp Ile Lys  Asn Ala Asn Thr Glu  Ile Leu Phe 
    1115                 1120                 1125             


Asn Asp  Asp Ile Arg Asn Asn  Lys Ile Ala Glu Ile  Asp Val Ile 
    1130                 1135                 1140             


Leu Lys  Lys Leu Asn Asp Lys  Leu Ser Gly Tyr Ser  Lys Glu Tyr 
    1145                 1150                 1155             


Lys Glu  Lys Tyr Ile Lys Lys  Leu Lys Glu Asn Gln  Glu Asn Asn 
    1160                 1165                 1170             


Asp Phe  Phe Ser Lys Asn Ile  Gln Asn Glu Asn Tyr  Ser Ser Phe 
    1175                 1180                 1185             


Arg Glu  Phe Lys Lys Asp Tyr  Asn Lys Val Ser Glu  Tyr Lys Lys 
    1190                 1195                 1200             


Ile Arg  Asp Leu Val Glu Phe  Asn Tyr Leu Asn Lys  Ile Glu Ser 
    1205                 1210                 1215             


Tyr Leu  Ile Asp Ile Asn Trp  Lys Leu Ala Ile Gln  Met Ala Arg 
    1220                 1225                 1230             


Phe Glu  Arg Asp Met His Tyr  Ile Val Asn Gly Leu  Arg Glu Leu 
    1235                 1240                 1245             


Gly Ile  Ile Lys Leu Asn Gly  Tyr Asn Thr Gly Ile  Ser Arg Ala 
    1250                 1255                 1260             


Tyr Pro  Lys Arg Asn Gly Thr  Gly Asp Phe Tyr Ile  Thr Thr Ala 
    1265                 1270                 1275             


Tyr Tyr  Lys Phe Phe Asp Glu  Glu Ser Tyr Lys Lys  Phe Glu Lys 
    1280                 1285                 1290             


Ile Cys  Tyr Gly Phe Gly Ile  Asp Leu Ser Glu Asn  Ser Glu Ile 
    1295                 1300                 1305             


Asn Lys  Pro Glu Asn Glu Ser  Ile Arg Asn Tyr Ile  Ser His Phe 
    1310                 1315                 1320             


Tyr Ile  Val Arg Asn Pro Phe  Val Asp Tyr Ser Ile  Ala Glu Gln 
    1325                 1330                 1335             


Ile Asp  Arg Val Ser Asn Leu  Leu Ser Tyr Ser Thr  Arg Tyr Asn 
    1340                 1345                 1350             


Asn Ser  Thr Tyr Ala Ser Val  Phe Glu Val Phe Lys  Lys Asp Val 
    1355                 1360                 1365             


Asp Leu  Asp Tyr Asp Lys Leu  Lys Thr Lys Phe Lys  Leu Phe Asp 
    1370                 1375                 1380             


Asp Glu  Lys Asn Asp Asp Ile  Lys Ile Leu Lys Ile  Glu Asp Leu 
    1385                 1390                 1395             


Ile Glu  Ser Lys Lys Val Ser  Val Leu Glu Leu Glu  Ser Tyr Asn 
    1400                 1405                 1410             


Ser Asn  Tyr Val Lys Asn Leu  Ile Ile Lys Leu Leu  Thr Lys Val 
    1415                 1420                 1425             


Glu Asn  Thr Asn Asn Thr Leu  
    1430                 1435 


<210>  171
<211>  1186
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  171

Met Lys Val Thr Lys Ile Asp Gly Leu Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ile Glu Asp Ala Ser Gln Lys Asn Glu Thr 
            20                  25                  30          


Leu Glu Arg Leu Glu Lys Leu Lys Glu Ile Lys Leu Gly Asn Tyr Ile 
        35                  40                  45              


Lys Asn Pro Asp Lys Thr Lys Asp Lys Asp Asn Lys Lys Arg Arg Lys 
    50                  55                  60                  


Gly Leu Lys Glu Tyr Phe Ser Glu Ile Thr Leu Arg Lys Glu Asn Glu 
65                  70                  75                  80  


Lys Tyr Val Leu Leu Lys Gly Lys Lys Leu Lys Lys Ile Asn Asn Asp 
                85                  90                  95      


Ile Lys Asp Thr Asp Ile Lys Val Lys Tyr Lys Lys Glu Glu Val Phe 
            100                 105                 110         


Asp Val Leu Lys Lys Ile Leu Lys Leu Asn Leu Leu Ala Asn Asp Val 
        115                 120                 125             


Glu Glu Lys Ile Gln Phe Asp Ser Ile Lys Leu Lys Asn Val Phe Gly 
    130                 135                 140                 


Lys Asp Phe Val Lys Lys Glu Leu Gln Ile Lys Ser Ile Glu Glu Ser 
145                 150                 155                 160 


Leu Glu Lys Asn Lys Ala Asp Tyr Arg Lys Glu Phe Ile Glu Ile Glu 
                165                 170                 175     


Asn Asp Lys Tyr Gly Asn Val Lys Gly Glu Asn Lys Lys Asn Arg Ile 
            180                 185                 190         


Tyr Glu Tyr Tyr Lys Lys Ser Glu Thr His Glu Lys Phe Arg Lys Asn 
        195                 200                 205             


Ile Ile Glu Ala Phe Glu Lys Leu Tyr Lys Lys Asp Asp Ile Glu Lys 
    210                 215                 220                 


Leu Tyr Thr Gln Ile Ile Glu Ile Ser Lys Lys Met His Leu Lys Ser 
225                 230                 235                 240 


Lys Val Arg Glu Leu Tyr Lys Asn Val Ile Ile Lys Arg Ser Cys Asp 
                245                 250                 255     


Asp Phe Ser Lys Lys Asn Lys Glu Gly Ile Ser Val Leu Tyr Ser Gln 
            260                 265                 270         


Ile Met Asn Ser Val Lys Lys Asn Glu Lys Phe Val Lys Phe Val Lys 
        275                 280                 285             


Asn Ile Glu Leu Lys Asp Leu Thr Lys Ser Gln Ile Phe Tyr Lys Tyr 
    290                 295                 300                 


Phe Leu Glu Asn Glu Glu Leu Asn Asp Glu Asn Ile Lys Asn Ile Phe 
305                 310                 315                 320 


Cys Tyr Phe Val Glu Ile Glu Val Ser Asp Leu Leu Lys Gly Asn Val 
                325                 330                 335     


Tyr Lys Val Ser Lys Ile Tyr Glu Asn Lys Ile Lys Asn Ile Phe Glu 
            340                 345                 350         


Tyr Asn Lys Leu Lys Lys Leu Val Ile Asn Lys Leu Glu Asn Lys Leu 
        355                 360                 365             


Asn Asn Tyr Val Arg Asn Cys Gly Lys Tyr Asn Tyr His Met Glu Asn 
    370                 375                 380                 


Gly Asp Ile Ala Thr Ser Asp Ile Asn Met Arg Asn Arg Gln Thr Glu 
385                 390                 395                 400 


Ala Phe Leu Arg Ser Met Ile Gly Val Ser Ser Phe Gly Tyr Phe Ser 
                405                 410                 415     


Leu Arg Asn Ile Leu Gly Val Asn Asp Asp Asp Phe Tyr Glu Ile Glu 
            420                 425                 430         


Glu Asp Leu Thr Glu Glu Glu Arg Lys Asn Glu Ser Asn Val Leu Lys 
        435                 440                 445             


Lys Ala Lys Glu Asp Ile Thr Ser Lys Ser Ile Phe Glu Lys Val Val 
    450                 455                 460                 


Asp Lys Ser Phe Glu Lys Lys Gly Ile His Ser Ile Arg Glu Asn Val 
465                 470                 475                 480 


Lys Met Phe Tyr Gly Asp Ser Phe Asp Lys Ala Asn Glu Asp Glu Leu 
                485                 490                 495     


Lys Gln Phe Phe Val Asn Met Leu Asn Ala Ile Thr Ser Ile Arg His 
            500                 505                 510         


Arg Val Val His Tyr Asn Met Asn Thr Asn Ser Glu Asn Ile Phe Asn 
        515                 520                 525             


Phe Ser Asp Ile Glu Val Ser Arg Leu Leu Lys Ser Ile Phe Glu Lys 
    530                 535                 540                 


Glu Thr Asp Lys Arg Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn 
545                 550                 555                 560 


Ser Ala Gly Val Phe Asp Tyr Trp Glu Asn Trp Lys Ile Lys Lys Tyr 
                565                 570                 575     


Leu Glu Asn Met Lys Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val 
            580                 585                 590         


Pro Ser Phe Thr Lys Leu Tyr Asn Arg Ile Asp Asn Leu Lys Gly Ser 
        595                 600                 605             


Asn Ala Leu Asn Leu Gly Tyr Ile Asn Ile Pro Lys Arg Lys Glu Ala 
    610                 615                 620                 


Arg Asp Ser Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Lys Phe 
625                 630                 635                 640 


Val Glu Glu Phe Ile Lys Asn Asn Asp Asn Phe Glu Lys Ile Phe Arg 
                645                 650                 655     


Glu Ile Ile Glu Ile Asn Lys Asn Ala Gly Thr Asn Lys Gln Thr Asn 
            660                 665                 670         


Phe Tyr Lys Leu Glu Lys Phe Glu Lys Leu Lys Ala Asn Thr Pro Thr 
        675                 680                 685             


Glu Tyr Leu Glu Lys Leu Gln Ser Leu His Lys Ile Asn Tyr Asn Arg 
    690                 695                 700                 


Glu Lys Ile Glu Glu Asp Lys Asp Ile Tyr Val Asp Phe Val Gln Lys 
705                 710                 715                 720 


Ile Phe Leu Lys Gly Phe Ile Ser Tyr Leu Gln Lys Ser Asn Ser Leu 
                725                 730                 735     


Lys Pro Leu Asn Leu Leu Asn Leu Lys Lys Asp Glu Val Ile Asn Ser 
            740                 745                 750         


Glu Lys Ser Phe Tyr Asp Glu Lys Leu Lys Gln Trp Glu Asn Asn Gly 
        755                 760                 765             


Ser Asn Leu Ser Glu Met Pro Lys Glu Ile Tyr Lys Tyr Ile Lys Glu 
    770                 775                 780                 


Ile Lys Ile Asn Lys Thr Asn Tyr Ser Asp Arg Met Ser Ile Phe Tyr 
785                 790                 795                 800 


Leu Leu Leu Lys Leu Ile Asp His Lys Glu Leu Thr Asn Leu Arg Gly 
                805                 810                 815     


Asn Leu Glu Lys Tyr Glu Ser Met Asn Lys Asn Lys Ile Tyr Ser Glu 
            820                 825                 830         


Glu Leu Asn Ile Val Asn Leu Val Ser Leu Asp Asn Asn Lys Val Arg 
        835                 840                 845             


Thr Asn Phe Ser Val Glu Ala Glu Asp Ile Gly Lys Phe Leu Lys Thr 
    850                 855                 860                 


Glu Thr Ser Ile Lys Asn Ile Asn Gln Leu Asn Asn Phe Ser Gly Ile 
865                 870                 875                 880 


Phe Ala Asp Gly Glu Asn Val Ile Lys His Arg Ser Phe Tyr Asn Ile 
                885                 890                 895     


Lys Lys Tyr Gly Ile Leu Asp Leu Leu Glu Lys Ile Val Ala Lys Ala 
            900                 905                 910         


Asp Leu Lys Ile Ala Lys Glu Glu Ile Lys Lys Tyr Glu Asn Leu Gln 
        915                 920                 925             


Asn Glu Leu Lys Arg Asn Asp Phe Tyr Lys Ile Gln Glu Lys Ile His 
    930                 935                 940                 


Arg Lys Tyr Asn Gln Lys Pro Asn Leu Ile Leu Arg Thr Glu Asn Lys 
945                 950                 955                 960 


Lys Asp Phe Asn Asp Tyr Lys Lys Ala Ile Glu Asn Ile Gln Asn Tyr 
                965                 970                 975     


Thr Gln Leu Lys Asn Lys Ile Glu Phe Asn Asp Leu Asn Leu Leu Gln 
            980                 985                 990         


Gly Leu Leu Phe Arg Ile Leu His  Arg Leu Ala Gly Tyr  Thr Ser Leu 
        995                 1000                 1005             


Trp Glu  Arg Asp Leu Gln Phe  Lys Leu Lys Gly Glu  Phe Pro Glu 
    1010                 1015                 1020             


Asp Lys  Tyr Ile Asp Glu Ile  Phe Asn Ser Asp Arg  Asn Asn Asn 
    1025                 1030                 1035             


Gln Lys  Tyr Lys Ser Gly Gly  Ile Ala Tyr Lys Tyr  Val Asp Phe 
    1040                 1045                 1050             


Leu Ile  Glu Lys Glu Glu Gly  Lys Arg Ala Gly Lys  Asn Lys Val 
    1055                 1060                 1065             


Lys Lys  Arg Ser Glu Lys Glu  Gly Ser Phe Ile Ile  Arg Asn Tyr 
    1070                 1075                 1080             


Ile Ala  His Phe Asn Tyr Ile  Pro Asp Ala Glu Lys  Ser Ile Leu 
    1085                 1090                 1095             


Glu Ile  Leu Glu Glu Leu Arg  Glu Leu Leu Lys Tyr  Asp Arg Lys 
    1100                 1105                 1110             


Leu Lys  Asn Ala Val Met Lys  Ser Val Lys Asp Ile  Phe Lys Glu 
    1115                 1120                 1125             


Tyr Gly  Phe Ile Val Glu Phe  Arg Ile Ser His Glu  Ser Asn Ser 
    1130                 1135                 1140             


Lys Lys  Ile Lys Val Leu Asp  Val Lys Ser Glu Lys  Ile Lys His 
    1145                 1150                 1155             


Leu Lys  Asn Asn Gly Leu Val  Thr Thr Lys Asn Ser  Glu Asp Leu 
    1160                 1165                 1170             


Cys Glu  Leu Val Lys Val Met  Leu Glu Tyr Lys Lys  Ser 
    1175                 1180                 1185     


<210>  172
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  172

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Asn Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Ser Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Asn Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Glu 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Val Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Lys 
        915                 920                 925             


Lys Tyr Glu Lys Ala Ile Arg Asn Ile Gln Gln Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Ser Leu Leu Leu 
945                 950                 955                 960 


Arg Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Asp 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Asn Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asp  Thr Glu Lys Ile Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Glu Leu  Lys Lys Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  Asn Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Lys Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Lys Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Glu  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  173
<211>  1425
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  173

Met Lys Leu Ser Lys Val Asp Arg Ile Arg Val Ala Val Gly Lys Thr 
1               5                   10                  15      


Gly Lys Thr Glu Asn Gly Asn Ser Gln Gly Arg Gly Val Leu Tyr Arg 
            20                  25                  30          


Ser Pro Lys Gly Asn Lys Thr Val Ala Val Asp Ala Val Val Glu Glu 
        35                  40                  45              


Arg Ile Arg Asn Ala Asn Arg Leu Tyr Ser Ala Phe Phe Arg Cys Ala 
    50                  55                  60                  


Tyr Pro Glu Glu Pro Glu Arg His Phe Glu Glu Ile Ile Lys Arg Met 
65                  70                  75                  80  


Ala Thr Gly Lys Lys Ser Gly Ala Gln Ile Leu Lys Glu Tyr Ile Gly 
                85                  90                  95      


Tyr Glu Gly Gln Lys Asn Arg Lys Pro Tyr Thr Phe Tyr Val Asn Lys 
            100                 105                 110         


Cys Ala Tyr Arg Pro Ala Gly Lys Glu Leu Gly Gln Val Leu Arg Leu 
        115                 120                 125             


Phe Val Lys Glu Arg Leu Gly Gln Asn Trp Gln Asn Pro Glu Ala Ala 
    130                 135                 140                 


Glu Ala Ala Val Ala Leu Leu Thr Cys Leu Cys Glu Gly Lys Thr Asn 
145                 150                 155                 160 


Arg Tyr Thr Glu Asn Thr Ala Asp Gly Pro Val Leu Thr Glu Leu Ser 
                165                 170                 175     


Glu Gln Thr Val Thr Gln Leu Glu Gln Val Ser Arg Leu Gly Gly Ser 
            180                 185                 190         


Ile Leu Val Pro Lys Thr Glu Arg Leu Glu Thr Ile Val Thr Val Ile 
        195                 200                 205             


Leu Arg Leu Thr Ala Glu Gln Cys Asn Thr Ser Leu Tyr Val Asn Gly 
    210                 215                 220                 


Gly Thr Lys Glu Ala Gln Asp Ala Asp Leu Glu Lys Gln Ile Ala Leu 
225                 230                 235                 240 


Leu Lys Ser Leu Gln Thr Lys Pro Leu Leu Leu Lys Glu Arg Phe Asp 
                245                 250                 255     


Lys Val Thr Lys Gln Thr Ile Arg Asp Glu Gln Lys Leu Ser Glu Phe 
            260                 265                 270         


Ser Tyr Lys Asp Ala Thr Lys Glu Arg Met Glu Ala Val Val Val Arg 
        275                 280                 285             


Met Arg Lys Thr Leu Lys Lys Gly Ala Ser Arg Glu Val Ala Val Glu 
    290                 295                 300                 


Leu Leu Gln Ala Leu Ala Gln Tyr Asp Gly Lys Thr Trp Asp Gly Trp 
305                 310                 315                 320 


Leu Thr Gln Met Leu Glu Thr Glu Ala Ser Lys Lys Lys Leu Lys Asp 
                325                 330                 335     


Phe Ile Leu Ala Val Asn Lys Asp Phe His His Phe His Val Ile Lys 
            340                 345                 350         


Ser Val Lys Asn Thr Ala Val Ala Val Ser His Ser Glu Asp Asn Thr 
        355                 360                 365             


Leu Gln Leu Ser Gly Ala Lys Lys Lys Thr Lys Gly Ala Met Gln Asp 
    370                 375                 380                 


Ala Leu Phe Ala Tyr Ala Gln Ser Glu Glu Ser Ser Asp Glu Thr Leu 
385                 390                 395                 400 


His Arg Ile Lys Arg Ile Leu Phe Thr Tyr Val Leu Gly Gly Arg Gln 
                405                 410                 415     


Asp Asn Thr Leu Arg Leu Thr Glu Lys Thr His Leu Ala Lys Glu Leu 
            420                 425                 430         


Leu Trp Lys Phe Arg Gly Thr Gly Ala Gly Leu Phe Asp Ala Asp Phe 
        435                 440                 445             


Val Pro Glu Glu Glu Arg Ala Gly Glu Ser Gly Arg Lys Ala Gly Ser 
    450                 455                 460                 


Tyr Thr Asp Leu Gly Cys Leu Phe Ala Glu Asp Asp Gly Ile Arg Asn 
465                 470                 475                 480 


Gln Arg Arg Ile Ala Asp Arg Ile Asn Tyr Val Asn Tyr Gly Asn Tyr 
                485                 490                 495     


Leu Arg Met Arg Lys Ala Ala Glu Asp Glu Phe Thr Leu Phe Trp Cys 
            500                 505                 510         


Ala Tyr Ile Lys Asp Tyr Ile Glu Glu Asn Tyr Val Thr Lys Ile Arg 
        515                 520                 525             


Glu Ala Lys Arg Thr Gly Gly Lys Arg Arg Leu Lys Glu Thr Asp Cys 
    530                 535                 540                 


Glu Ala Glu Arg Met Met Glu Lys Cys Trp His Asp Ile Ile Arg Tyr 
545                 550                 555                 560 


Ile Cys Gly Lys Tyr Ile His Ile Gly Lys Ala Val Tyr His Phe Ala 
                565                 570                 575     


Ile Pro Glu Asp Leu Leu Ala Asn Pro Gly Glu Val Arg Ser Phe Gly 
            580                 585                 590         


Asp Val His Ala Lys Tyr Ala Asp Gly Ile Thr Ser Phe Asp Tyr Glu 
        595                 600                 605             


Asp Ile Lys Ala Glu Glu Asn Leu Gln Lys Ser Ile Phe Asn Val Leu 
    610                 615                 620                 


Val Ser Ala Val Ala Asn Tyr Ser Arg Ser Val Val Asp Leu Ser Ser 
625                 630                 635                 640 


Glu Arg Ala Glu Glu Leu Arg Arg Leu Pro Gly Asn Glu Arg Leu Asn 
                645                 650                 655     


Glu Asp Val Leu Met Met Lys Glu Thr His Leu Lys Glu Leu Leu Leu 
            660                 665                 670         


Pro Asp Ala Lys Lys Arg Leu Leu Arg Tyr Phe Gly Gly Tyr Ser Ala 
        675                 680                 685             


Cys Glu Gly Leu Ser Gly Val Thr Ser Glu Glu Leu Ala Trp Glu Met 
    690                 695                 700                 


Arg Thr Val Leu Ser Thr Leu Arg Asn Glu Ser Phe His Tyr Thr Phe 
705                 710                 715                 720 


Gly Lys Lys Lys Lys Leu Asp Tyr Lys Val Ala Lys Gln Leu Trp Met 
                725                 730                 735     


Gln Ala Ile Arg Ala Asn Arg Gln Leu Ile Leu Asp Lys Tyr Tyr Ser 
            740                 745                 750         


Asn Asn Thr Cys Arg Tyr Tyr Ser Pro Asn Ser Ile Lys Ala Leu Ile 
        755                 760                 765             


Glu Gln Gly Tyr Arg Ser Tyr Glu Glu Arg Glu Ala Gln Ile Pro Ala 
    770                 775                 780                 


Phe Lys Thr Val Trp Lys Lys Ala Glu Leu Ala Lys Tyr Leu Ala Asp 
785                 790                 795                 800 


Lys Lys Val Met Pro Ala Glu Ile Ser Gly Glu Glu Lys Glu Arg Val 
                805                 810                 815     


Ile Phe Gln Gly Ala Phe Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg 
            820                 825                 830         


Glu Phe Thr Val Gly Asn Thr Ala Ala Lys Tyr Phe Phe Asp Ala Val 
        835                 840                 845             


Glu Arg Tyr Cys Lys Glu Asn Glu Thr Gly Pro Tyr Lys Asn Pro Ala 
    850                 855                 860                 


Lys Ser Phe Asn Asp Tyr Val Asn Gly Ala Phe Asn Asn Lys Gly Val 
865                 870                 875                 880 


Lys Val Gln Lys Gly Leu Ser Asp Leu Tyr Arg Glu Gly Lys Ile Thr 
                885                 890                 895     


Phe Gly Val Val Cys Gln Thr Ile Met Ala Glu Tyr Thr Gln Gln Asn 
            900                 905                 910         


Glu Lys Ser Glu Gly Glu Ala Ile Tyr Gln His Phe Lys Met Leu Phe 
        915                 920                 925             


Pro Leu Cys Met Arg Lys Gly Phe Gln Lys Tyr Val Glu Glu Lys His 
    930                 935                 940                 


Lys Glu Leu Leu Gln Pro Val Ile Arg Glu Met Gly Ser Arg Glu Asp 
945                 950                 955                 960 


Phe Leu Thr Asn Ile His Ile Gly Cys Phe Asp Asp Phe Cys Arg Glu 
                965                 970                 975     


Asp Gly Met Tyr Glu Tyr Asp Trp Phe Val Val Ala His Leu Ile His 
            980                 985                 990         


Pro Lys Arg Leu Asn Glu Leu Val  Gly Asn Leu Lys Asp  Tyr Met Gln 
        995                 1000                 1005             


Phe Lys  Gln Asp Ile Leu Arg  Arg Ala Asp Tyr Val  Glu Gln Phe 
    1010                 1015                 1020             


Thr Lys  Glu Glu Leu Ala Ala  Met Lys Ala Arg Thr  Glu Glu Lys 
    1025                 1030                 1035             


Leu Gln  Lys Ile Ser Gly Ile  Leu Arg Val Ala Glu  Phe Val Arg 
    1040                 1045                 1050             


Gly Ile  Ala Gly Arg Val Ser  Asn Thr Phe Ser Asp  Tyr Tyr Glu 
    1055                 1060                 1065             


Ser Glu  Glu Ala Tyr Ala Ser  Tyr Leu Glu Gln Tyr  Ile Glu Phe 
    1070                 1075                 1080             


Pro Arg  Ile Lys Gly Ser Thr  Val Phe Glu Ser Phe  Arg Asp Phe 
    1085                 1090                 1095             


Cys Val  Asn Thr Leu Pro Gly  Gly Ala Val Met Asp  Val Tyr Met 
    1100                 1105                 1110             


Asp Glu  Lys Asn Pro Arg Ile  Leu Arg Asn Val Glu  Val Ala Arg 
    1115                 1120                 1125             


Met Tyr  Ala Gly Gly Asp Ile  Gly Leu Arg Thr Arg  Lys Lys Val 
    1130                 1135                 1140             


Thr Ala  Glu Glu Leu Lys Arg  Tyr Tyr Gln Asn Glu  Ala Glu Val 
    1145                 1150                 1155             


Ala Ala  Leu Leu Lys Ala Gly  Leu Cys Ala Thr Ala  Glu Asp Gln 
    1160                 1165                 1170             


Lys Arg  Val Lys Ala Gln Gln  Glu Leu Arg Asn Arg  Ile Thr Leu 
    1175                 1180                 1185             


Thr Asp  Val Thr Glu Ile Gln  Glu Val Ile Asn Asp  Leu Leu Ser 
    1190                 1195                 1200             


Gln Leu  Val Thr Phe Ser Tyr  Phe Arg Glu Arg Asp  Glu Met Tyr 
    1205                 1210                 1215             


Leu Leu  Leu Gly Phe Tyr Tyr  Met Ala Leu Gln Ser  Asp Gly Asp 
    1220                 1225                 1230             


Trp Gly  Glu Glu Leu Arg Val  Phe Asp Gly Lys Lys  Leu Gln Val 
    1235                 1240                 1245             


Glu Asn  Gly Phe Val Leu Tyr  Gln Leu Leu Ser Ala  Phe Thr Tyr 
    1250                 1255                 1260             


Gly Leu  Asn Met Tyr Ser Glu  Ala Ala Pro Asp Gly  Lys Gly Gly 
    1265                 1270                 1275             


Ser Gln  Ala Gly Lys Ile Gly  Glu Phe Ile Lys Ala  His Pro Asn 
    1280                 1285                 1290             


Ser Trp  Asp Arg Ala Leu Arg  Leu Phe Val Asp Asp  Gly Ala Cys 
    1295                 1300                 1305             


Glu Glu  Val Ser Arg Lys Ala  Arg Asn Tyr Val Asp  His Phe Arg 
    1310                 1315                 1320             


Tyr Tyr  Val Lys Pro Asp Arg  Ser Ile Met Asp Leu  Tyr Ala Val 
    1325                 1330                 1335             


Tyr His  Glu Tyr Phe Phe Asp  Tyr Ser Thr Lys Met  Arg Lys Ser 
    1340                 1345                 1350             


Val Leu  Gln Asn Phe Ala Ser  Ile Leu Glu Arg Tyr  Phe Val Leu 
    1355                 1360                 1365             


Thr Lys  Phe Lys Leu Gly Gly  Glu Arg Gly Ala Gln  Thr Leu Glu 
    1370                 1375                 1380             


Ala Glu  Leu Ser Gly Asp Lys  Phe Thr Tyr Lys Leu  Ser Asp Thr 
    1385                 1390                 1395             


Lys Ala  Lys Pro Val Val Leu  Pro Ala Arg Asn Lys  Glu Phe Leu 
    1400                 1405                 1410             


Glu Asn  Leu Lys Asn Glu Leu  Asn Tyr Arg Gln Glu  
    1415                 1420                 1425 


<210>  174
<211>  1276
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  174

Met Arg Ile Val Arg Pro Tyr Gly Glu Ser Arg Thr Asp Leu Gly Gly 
1               5                   10                  15      


Glu Arg Gly Gln Thr Arg Val Leu Val Asp Asn Thr Ala Ala Arg Ala 
            20                  25                  30          


Arg His Glu Ile Pro Asp Phe Ala Gln Ser His Asp Ala Leu Val Ile 
        35                  40                  45              


Ala Gln Trp Ile Ser Val Leu Asp Arg Ile Ala Thr Lys Pro Gln Gly 
    50                  55                  60                  


Thr Gln Gly Ala Thr Arg Ala Gln His Ala Phe Arg Asp Arg Leu Gly 
65                  70                  75                  80  


Arg Ala Ala Trp Ala Gln Met Cys Ala Ala Asp Arg Ile Ser Ala Ala 
                85                  90                  95      


Ala Gln Ala Asp Pro Tyr Val Ala Ala Leu Trp Arg Phe Lys Thr His 
            100                 105                 110         


Pro Tyr Gly Asp Ala Lys Tyr Arg Pro Arg Lys Gly Lys Asp Gly Lys 
        115                 120                 125             


Pro Leu Gly Glu Pro Lys Pro Gln Gly Arg Trp Tyr Gly Arg Phe Ala 
    130                 135                 140                 


Ala Asn Ala Glu Pro Glu Gln Ala Asp Val Ala Ala Ile Ala Ala Leu 
145                 150                 155                 160 


Met Asp His His Leu His Val Ala Glu Leu Arg Ile Asp Pro Lys Arg 
                165                 170                 175     


Pro Glu Lys Arg Lys Gly Leu Ile Glu Ala Arg Ala Lys Ser Ile Glu 
            180                 185                 190         


Gly Asn Val Leu Val Ala Glu Pro Arg Lys Arg Pro Val Gly Ser Trp 
        195                 200                 205             


Ser Arg Glu Ala Ile Thr Arg Tyr Phe Met Arg Gln Asp Val Ala Ala 
    210                 215                 220                 


Glu Ile Phe Ala Ala Ala Arg Asp Arg Glu Gln Gly Leu Asn Asp Val 
225                 230                 235                 240 


Pro Arg Gly Pro Val Arg Leu Ala Leu Ala Ala Lys Ile Leu His Gly 
                245                 250                 255     


His Trp Thr Arg Leu Phe His Ala Pro Gly Thr Arg Thr Ala Tyr Ser 
            260                 265                 270         


Ile Arg Glu Ala Glu Glu Lys Glu Pro Glu Leu Phe Ala Leu His Met 
        275                 280                 285             


Ala Val Lys Asp Ala Tyr Ala Lys Leu Leu Lys Arg Arg Thr Gln Pro 
    290                 295                 300                 


Lys Thr Leu Lys Lys Gly Val Lys Pro Pro Gln Gln Ala Pro Val Thr 
305                 310                 315                 320 


Thr Val Leu Pro Lys Asn Ala Gly Glu Leu Leu Arg Leu Val Gln His 
                325                 330                 335     


Arg Ser Arg Asn Arg Asp Leu Ser Ala Leu Ile Arg Arg Gly Lys Leu 
            340                 345                 350         


Ile His Tyr Thr Ala Phe Asp Ile Ala Ala Ala Ala Ala Glu Ala Glu 
        355                 360                 365             


Ser Lys Thr Pro Asp Val Pro Asp Ala Asp Arg Leu Ala Tyr Val Leu 
    370                 375                 380                 


Thr His Trp Pro Asp Asp Leu Ser Ala Ser Arg Tyr Leu Thr Ser Asp 
385                 390                 395                 400 


Gly Gln Ser Ala Ile Lys Arg Ser Glu Ala Phe Val Arg Val Trp Arg 
                405                 410                 415     


His Thr Ile Ala Met Ala Ser Leu Thr Leu Arg Asp Trp Ala Ser Met 
            420                 425                 430         


Asn Asn Asp Leu Gly Asp Val Leu Gly Ser Ala Asn Lys Val Asp Gln 
        435                 440                 445             


Ala Ile Gly Arg Ala Asn Phe Asp Pro Ala Trp His Asp Lys Lys Val 
    450                 455                 460                 


Arg Leu Leu Phe Gly Ala Arg Ala Ala Leu Phe Pro Ser Asp Asp Asp 
465                 470                 475                 480 


Gly Arg Lys Ala Leu Leu Ala Ser Val Ile Arg Ala Gly Leu Ala Leu 
                485                 490                 495     


Arg Asn Ser Ser Phe His Phe Thr Gly Arg Gly Gly Phe Leu Ala Ala 
            500                 505                 510         


Leu Lys Lys Leu Gly Ser Glu Glu Val Met Val Pro Ser Ile Leu Ala 
        515                 520                 525             


Ala Ala His Ala Leu Trp Arg Glu Asp Ala Thr Ala Arg Ala Gly Arg 
    530                 535                 540                 


Leu Arg Ala Ala Leu Thr Gly Ala His Ala Ala His Tyr Phe Glu Glu 
545                 550                 555                 560 


Asp Gln Asn Ala Ser Ile Leu Thr Leu Leu Asp Glu Ala Pro Pro Lys 
                565                 570                 575     


Glu Ser Leu Pro Ile Pro Arg Phe Arg Arg Val Leu Gly Arg Ala Glu 
            580                 585                 590         


Asn Thr Trp Lys Gly Lys Glu Ala Leu Val Leu Pro Pro Thr Ala Asn 
        595                 600                 605             


Arg Arg Gln Leu Glu Asp Pro Ala Arg Arg Cys Arg Tyr Thr Ile Leu 
    610                 615                 620                 


Lys Ala Leu Tyr Glu Arg Pro Phe Arg Ser Trp Leu Ile Ala Arg Ala 
625                 630                 635                 640 


Pro Glu Glu Val Asn Ala Trp Ile Asp Arg Ala Ile Glu Arg Thr Thr 
                645                 650                 655     


Arg Ala Ala Lys Asp Met Asn Ala Lys Arg Gly Glu Asp Asp Lys Arg 
            660                 665                 670         


Ser Val Ile Ala Ala Lys Ala Glu Ser Leu Pro Arg Leu Ser Gly Glu 
        675                 680                 685             


Arg Gly Ile Gly Asp Phe Phe Phe Asp Leu Ser Ser Ala Thr Ala Ser 
    690                 695                 700                 


Glu Met Arg Val Gln Arg Gly Tyr Gly His Asp Gly Glu Ala Ala Lys 
705                 710                 715                 720 


Glu Gln Ala Gly Tyr Ile Asp Asp Leu Leu Cys Asp Val Val Ala Leu 
                725                 730                 735     


Ala Phe Asp Ala Trp Leu Arg Asn Pro Gln Ala Asn Gly Arg Pro Leu 
            740                 745                 750         


Thr Phe Ile Cys Asp Leu Lys Pro Glu Thr Pro Leu Pro Ala Ala Pro 
        755                 760                 765             


Lys Cys Thr Leu Gln Glu Ile Gly Ser Ala Ala Glu Pro Val Arg Pro 
    770                 775                 780                 


Glu Asp Trp Gln Ala Ala Leu Tyr Leu Leu Leu His Leu Val Pro Val 
785                 790                 795                 800 


Gly Glu Ala Gly Arg Leu Leu His Gln Leu Ala Lys Trp Thr Val Thr 
                805                 810                 815     


Ser Arg Leu Ala Asp Asp Leu Leu Asn Ala Asn Val Thr Asp Asp Pro 
            820                 825                 830         


Ser Lys Ala Glu Arg Thr Ala Asp Glu Glu Asp Leu Lys Arg Leu Val 
        835                 840                 845             


His Thr Leu Ile Gln His Leu Asp Met His Asp Ala Lys Phe Glu Gly 
    850                 855                 860                 


Gly Asp Ala Leu Thr Gly Cys Glu Pro Phe Ala Ala Leu Phe Ala Ser 
865                 870                 875                 880 


Arg Pro Gly Phe Ala Arg Ile Phe Pro Ala Glu Ala Asp Glu Arg Leu 
                885                 890                 895     


Asp Arg Arg Val Pro Lys Arg Gly Leu Arg Glu Ile Met Arg Phe Gly 
            900                 905                 910         


His His Gly Leu Val Ala Ser Phe Ala Glu Asp Thr Arg Ile Thr Asp 
        915                 920                 925             


Lys Glu Val Gly Asp Tyr Leu Arg Leu Glu Ile Glu Glu Arg Pro Asp 
    930                 935                 940                 


Asn Val Ala Ala Leu Gln Ala Arg Lys Glu Glu Ala His Glu Arg Trp 
945                 950                 955                 960 


Val Lys Ala Lys Glu Lys Arg Lys Thr Val Asp Pro Lys His Leu Glu 
                965                 970                 975     


Asp Tyr Val Thr Ala Leu Cys Gly Ile Ala Arg His Arg Arg Leu Ala 
            980                 985                 990         


Ser Arg Val Thr Leu Thr Asp Gln  Val Gln Val His Arg  Leu Leu Met 
        995                 1000                 1005             


Thr Val  Leu Gly Arg Leu Val  Asp Phe Ser Gly Met  Phe Glu Arg 
    1010                 1015                 1020             


Asp Leu  Tyr Phe Ala Met Leu  Gly Leu Leu Asp Glu  Lys Gly Ala 
    1025                 1030                 1035             


Arg Pro  Asp Glu Val Phe Ser  Gly Pro Ile Asp Glu  Pro Lys Ser 
    1040                 1045                 1050             


Arg Leu  Ala Leu Leu Ala Asn  Gly Arg Val Leu Ala  Ala Leu Arg 
    1055                 1060                 1065             


Glu Gln  Ile Pro His Ser Lys  Asp Leu Ala Glu Glu  Leu Arg Lys 
    1070                 1075                 1080             


Asp Leu  Glu Arg Leu Phe Gly  Met Asp Cys Ser Gly  Ile Arg Leu 
    1085                 1090                 1095             


Leu Glu  Ala Asp Glu Arg Gly  Asp Thr Cys Leu Arg  Asp Ile Arg 
    1100                 1105                 1110             


Asn Asp  Leu Ser His Phe Asn  Leu Leu His Asp Asp  Ser Phe Ala 
    1115                 1120                 1125             


Leu Asp  Leu Thr Thr Leu Val  Asn Arg Thr Arg Gly  Leu Met Ser 
    1130                 1135                 1140             


Tyr Asp  Arg Lys Leu Lys Asn  Ala Val Ser Lys Ser  Ile Lys Glu 
    1145                 1150                 1155             


Leu Leu  Ala Arg Glu Gly Leu  Thr Leu Ser Trp Asp  Met Thr Asp 
    1160                 1165                 1170             


Arg His  Asp Leu Glu Asn Ala  Arg Ile Gly Ala Lys  Pro Ala Val 
    1175                 1180                 1185             


His Leu  Gly Gly Arg Lys Leu  Ala Phe Arg Gly Gly  Asp Arg Arg 
    1190                 1195                 1200             


Pro Glu  Pro Val Arg Glu Asn  Leu His Ser Pro Thr  His Leu Glu 
    1205                 1210                 1215             


Ala Val  Ala Arg Leu Phe Gly  Gly Lys Val Val Glu  Glu Asp Asp 
    1220                 1225                 1230             


Val Thr  Asn Leu Asp Leu Ser  Ser Ile Asp Trp Ala  Ala Glu Pro 
    1235                 1240                 1245             


His Asn  Ser Lys Glu Thr His  Arg His Arg Pro Ala  Gly Pro Arg 
    1250                 1255                 1260             


Lys Ser  Pro Pro Lys Arg Arg  Ala Tyr His Ala Pro  Arg 
    1265                 1270                 1275     


<210>  175
<211>  1349
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  175

Met Pro Leu Gln Ala Ala Gly Phe Gly Lys Pro Arg Arg Ser Pro Met 
1               5                   10                  15      


Arg Trp Leu Gln Ala Leu Ser Arg Pro Glu Arg Arg Lys Pro Gly Arg 
            20                  25                  30          


Trp Cys Gly Lys Ser Ala Arg Pro Asn Gly Thr Val Ala Asn Gly Leu 
        35                  40                  45              


Asp Gly Leu His Pro Cys Leu Gly Gly Phe Cys Ala Gly Gly Ala Thr 
    50                  55                  60                  


Met Gln Ile Gly Lys Val Gln Gly Arg Thr Ile Ser Glu Phe Gly Asp 
65                  70                  75                  80  


Pro Ala Gly Gly Leu Lys Arg Lys Ile Ser Thr Asp Gly Lys Asn Arg 
                85                  90                  95      


Lys Glu Leu Pro Ala His Leu Ser Ser Asp Pro Lys Ala Leu Ile Gly 
            100                 105                 110         


Gln Trp Ile Ser Gly Ile Asp Lys Ile Tyr Arg Lys Pro Asp Ser Arg 
        115                 120                 125             


Lys Ser Asp Gly Lys Ala Ile His Ser Pro Thr Pro Ser Lys Met Gln 
    130                 135                 140                 


Phe Asp Ala Arg Asp Asp Leu Gly Glu Ala Phe Trp Lys Leu Val Ser 
145                 150                 155                 160 


Glu Ala Gly Leu Ala Gln Asp Ser Asp Tyr Asp Gln Phe Lys Arg Arg 
                165                 170                 175     


Leu His Pro Tyr Gly Asp Lys Phe Gln Pro Ala Asp Ser Gly Ala Lys 
            180                 185                 190         


Leu Lys Phe Glu Ala Asp Pro Pro Glu Pro Gln Ala Phe His Gly Arg 
        195                 200                 205             


Trp Tyr Gly Ala Met Ser Lys Arg Gly Asn Asp Ala Lys Glu Leu Ala 
    210                 215                 220                 


Ala Ala Leu Tyr Glu His Leu His Val Asp Glu Lys Arg Ile Asp Gly 
225                 230                 235                 240 


Gln Pro Lys Arg Asn Pro Lys Thr Asp Lys Phe Ala Pro Gly Leu Val 
                245                 250                 255     


Val Ala Arg Ala Leu Gly Ile Glu Ser Ser Val Leu Pro Arg Gly Met 
            260                 265                 270         


Ala Arg Leu Ala Arg Asn Trp Gly Glu Glu Glu Ile Gln Thr Tyr Phe 
        275                 280                 285             


Val Val Asp Val Ala Ala Ser Val Lys Glu Val Ala Lys Ala Ala Val 
    290                 295                 300                 


Ser Ala Ala Gln Ala Phe Asp Pro Pro Arg Gln Val Ser Gly Arg Ser 
305                 310                 315                 320 


Leu Ser Pro Lys Val Gly Phe Ala Leu Ala Glu His Leu Glu Arg Val 
                325                 330                 335     


Thr Gly Ser Lys Arg Cys Ser Phe Asp Pro Ala Ala Gly Pro Ser Val 
            340                 345                 350         


Leu Ala Leu His Asp Glu Val Lys Lys Thr Tyr Lys Arg Leu Cys Ala 
        355                 360                 365             


Arg Gly Lys Asn Ala Ala Arg Ala Phe Pro Ala Asp Lys Thr Glu Leu 
    370                 375                 380                 


Leu Ala Leu Met Arg His Thr His Glu Asn Arg Val Arg Asn Gln Met 
385                 390                 395                 400 


Val Arg Met Gly Arg Val Ser Glu Tyr Arg Gly Gln Gln Ala Gly Asp 
                405                 410                 415     


Leu Ala Gln Ser His Tyr Trp Thr Ser Ala Gly Gln Thr Glu Ile Lys 
            420                 425                 430         


Glu Ser Glu Ile Phe Val Arg Leu Trp Val Gly Ala Phe Ala Leu Ala 
        435                 440                 445             


Gly Arg Ser Met Lys Ala Trp Ile Asp Pro Met Gly Lys Ile Val Asn 
    450                 455                 460                 


Thr Glu Lys Asn Asp Arg Asp Leu Thr Ala Ala Val Asn Ile Arg Gln 
465                 470                 475                 480 


Val Ile Ser Asn Lys Glu Met Val Ala Glu Ala Met Ala Arg Arg Gly 
                485                 490                 495     


Ile Tyr Phe Gly Glu Thr Pro Glu Leu Asp Arg Leu Gly Ala Glu Gly 
            500                 505                 510         


Asn Glu Gly Phe Val Phe Ala Leu Leu Arg Tyr Leu Arg Gly Cys Arg 
        515                 520                 525             


Asn Gln Thr Phe His Leu Gly Ala Arg Ala Gly Phe Leu Lys Glu Ile 
    530                 535                 540                 


Arg Lys Glu Leu Glu Lys Thr Arg Trp Gly Lys Ala Lys Glu Ala Glu 
545                 550                 555                 560 


His Val Val Leu Thr Asp Lys Thr Val Ala Ala Ile Arg Ala Ile Ile 
                565                 570                 575     


Asp Asn Asp Ala Lys Ala Leu Gly Ala Arg Leu Leu Ala Asp Leu Ser 
            580                 585                 590         


Gly Ala Phe Val Ala His Tyr Ala Ser Lys Glu His Phe Ser Thr Leu 
        595                 600                 605             


Tyr Ser Glu Ile Val Lys Ala Val Lys Asp Ala Pro Glu Val Ser Ser 
    610                 615                 620                 


Gly Leu Pro Arg Leu Lys Leu Leu Leu Lys Arg Ala Asp Gly Val Arg 
625                 630                 635                 640 


Gly Tyr Val His Gly Leu Arg Asp Thr Arg Lys His Ala Phe Ala Thr 
                645                 650                 655     


Lys Leu Pro Pro Pro Pro Ala Pro Arg Glu Leu Asp Asp Pro Ala Thr 
            660                 665                 670         


Lys Ala Arg Tyr Ile Ala Leu Leu Arg Leu Tyr Asp Gly Pro Phe Arg 
        675                 680                 685             


Ala Tyr Ala Ser Gly Ile Thr Gly Thr Ala Leu Ala Gly Pro Ala Ala 
    690                 695                 700                 


Arg Ala Lys Glu Ala Ala Thr Ala Leu Ala Gln Ser Val Asn Val Thr 
705                 710                 715                 720 


Lys Ala Tyr Ser Asp Val Met Glu Gly Arg Ser Ser Arg Leu Arg Pro 
                725                 730                 735     


Pro Asn Asp Gly Glu Thr Leu Arg Glu Tyr Leu Ser Ala Leu Thr Gly 
            740                 745                 750         


Glu Thr Ala Thr Glu Phe Arg Val Gln Ile Gly Tyr Glu Ser Asp Ser 
        755                 760                 765             


Glu Asn Ala Arg Lys Gln Ala Glu Phe Ile Glu Asn Tyr Arg Arg Asp 
    770                 775                 780                 


Met Leu Ala Phe Met Phe Glu Asp Tyr Ile Arg Ala Lys Gly Phe Asp 
785                 790                 795                 800 


Trp Ile Leu Lys Ile Glu Pro Gly Ala Thr Ala Met Thr Arg Ala Pro 
                805                 810                 815     


Val Leu Pro Glu Pro Ile Asp Thr Arg Gly Gln Tyr Glu His Trp Gln 
            820                 825                 830         


Ala Ala Leu Tyr Leu Val Met His Phe Val Pro Ala Ser Asp Val Ser 
        835                 840                 845             


Asn Leu Leu His Gln Leu Arg Lys Trp Glu Ala Leu Gln Gly Lys Tyr 
    850                 855                 860                 


Glu Leu Val Gln Asp Gly Asp Ala Thr Asp Gln Ala Asp Ala Arg Arg 
865                 870                 875                 880 


Glu Ala Leu Asp Leu Val Lys Arg Phe Arg Asp Val Leu Val Leu Phe 
                885                 890                 895     


Leu Lys Thr Gly Glu Ala Arg Phe Glu Gly Arg Ala Ala Pro Phe Asp 
            900                 905                 910         


Leu Lys Pro Phe Arg Ala Leu Phe Ala Asn Pro Ala Thr Phe Asp Arg 
        915                 920                 925             


Leu Phe Met Ala Thr Pro Thr Thr Ala Arg Pro Ala Glu Asp Asp Pro 
    930                 935                 940                 


Glu Gly Asp Gly Ala Ser Glu Pro Glu Leu Arg Val Ala Arg Thr Leu 
945                 950                 955                 960 


Arg Gly Leu Arg Gln Ile Ala Arg Tyr Asn His Met Ala Val Leu Ser 
                965                 970                 975     


Asp Leu Phe Ala Lys His Lys Val Arg Asp Glu Glu Val Ala Arg Leu 
            980                 985                 990         


Ala Glu Ile Glu Asp Glu Thr Gln  Glu Lys Ser Gln Ile  Val Ala Ala 
        995                 1000                 1005             


Gln Glu  Leu Arg Thr Asp Leu  His Asp Lys Val Met  Lys Cys His 
    1010                 1015                 1020             


Pro Lys  Thr Ile Ser Pro Glu  Glu Arg Gln Ser Tyr  Ala Ala Ala 
    1025                 1030                 1035             


Ile Lys  Thr Ile Glu Glu His  Arg Phe Leu Val Gly  Arg Val Tyr 
    1040                 1045                 1050             


Leu Gly  Asp His Leu Arg Leu  His Arg Leu Met Met  Asp Val Ile 
    1055                 1060                 1065             


Gly Arg  Leu Ile Asp Tyr Ala  Gly Ala Tyr Glu Arg  Asp Thr Gly 
    1070                 1075                 1080             


Thr Phe  Leu Ile Asn Ala Ser  Lys Gln Leu Gly Ala  Gly Ala Asp 
    1085                 1090                 1095             


Trp Ala  Val Thr Ile Ala Gly  Ala Ala Asn Thr Asp  Ala Arg Thr 
    1100                 1105                 1110             


Gln Thr  Arg Lys Asp Leu Ala  His Phe Asn Val Leu  Asp Arg Ala 
    1115                 1120                 1125             


Asp Gly  Thr Pro Asp Leu Thr  Ala Leu Val Asn Arg  Ala Arg Glu 
    1130                 1135                 1140             


Met Met  Ala Tyr Asp Arg Lys  Arg Lys Asn Ala Val  Pro Arg Ser 
    1145                 1150                 1155             


Ile Leu  Asp Met Leu Ala Arg  Leu Gly Leu Thr Leu  Lys Trp Gln 
    1160                 1165                 1170             


Met Lys  Asp His Leu Leu Gln  Asp Ala Thr Ile Thr  Gln Ala Ala 
    1175                 1180                 1185             


Ile Lys  His Leu Asp Lys Val  Arg Leu Thr Val Gly  Gly Pro Ala 
    1190                 1195                 1200             


Ala Val  Thr Glu Ala Arg Phe  Ser Gln Asp Tyr Leu  Gln Met Val 
    1205                 1210                 1215             


Ala Ala  Val Phe Asn Gly Ser  Val Gln Asn Pro Lys  Pro Arg Arg 
    1220                 1225                 1230             


Arg Asp  Asp Gly Asp Ala Trp  His Lys Pro Pro Lys  Pro Ala Thr 
    1235                 1240                 1245             


Ala Gln  Ser Gln Pro Asp Gln  Lys Pro Pro Asn Lys  Ala Pro Ser 
    1250                 1255                 1260             


Ala Gly  Ser Arg Leu Pro Pro  Pro Gln Val Gly Glu  Val Tyr Glu 
    1265                 1270                 1275             


Gly Val  Val Val Lys Val Ile  Asp Thr Gly Ser Leu  Gly Phe Leu 
    1280                 1285                 1290             


Ala Val  Glu Gly Val Ala Gly  Asn Ile Gly Leu His  Ile Ser Arg 
    1295                 1300                 1305             


Leu Arg  Arg Ile Arg Glu Asp  Ala Ile Ile Val Gly  Arg Arg Tyr 
    1310                 1315                 1320             


Arg Phe  Arg Val Glu Ile Tyr  Val Pro Pro Lys Ser  Asn Thr Ser 
    1325                 1330                 1335             


Lys Leu  Asn Ala Ala Asp Leu  Val Arg Ile Asp 
    1340                 1345                 


<210>  176
<211>  1349
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  176

Met Pro Leu Gln Ala Ala Gly Phe Gly Lys Pro Arg Arg Ser Pro Met 
1               5                   10                  15      


Arg Trp Leu Gln Ala Leu Ser Arg Pro Glu Arg Arg Lys Pro Gly Arg 
            20                  25                  30          


Trp Cys Gly Lys Ser Ala Arg Pro Asn Gly Thr Val Ala Asn Gly Leu 
        35                  40                  45              


Asp Gly Leu His Pro Cys Leu Gly Gly Phe Cys Ala Gly Gly Ala Thr 
    50                  55                  60                  


Met Gln Ile Gly Lys Val Gln Gly Arg Thr Ile Ser Glu Phe Gly Asp 
65                  70                  75                  80  


Pro Ala Gly Gly Leu Lys Arg Lys Ile Ser Thr Asp Gly Lys Asn Arg 
                85                  90                  95      


Lys Glu Leu Pro Ala His Leu Ser Ser Asp Pro Lys Ala Leu Ile Gly 
            100                 105                 110         


Gln Trp Ile Ser Gly Ile Asp Lys Ile Tyr Arg Lys Pro Asp Ser Arg 
        115                 120                 125             


Lys Ser Asp Gly Lys Ala Ile His Ser Pro Thr Pro Ser Lys Met Gln 
    130                 135                 140                 


Phe Asp Ala Arg Asp Asp Leu Gly Glu Ala Phe Trp Lys Leu Val Ser 
145                 150                 155                 160 


Glu Ala Gly Leu Ala Gln Asp Ser Asp Tyr Asp Gln Phe Lys Arg Arg 
                165                 170                 175     


Leu His Pro Tyr Gly Asp Lys Phe Gln Pro Ala Asp Ser Gly Ala Lys 
            180                 185                 190         


Leu Lys Phe Glu Ala Asp Pro Pro Glu Pro Gln Ala Phe His Gly Arg 
        195                 200                 205             


Trp Tyr Gly Ala Met Ser Lys Arg Gly Asn Asp Ala Lys Glu Leu Ala 
    210                 215                 220                 


Ala Ala Leu Tyr Glu His Leu His Val Asp Glu Lys Arg Ile Asp Gly 
225                 230                 235                 240 


Gln Pro Lys Arg Asn Pro Lys Thr Asp Lys Phe Ala Pro Gly Leu Val 
                245                 250                 255     


Val Ala Arg Ala Leu Gly Ile Glu Ser Ser Val Leu Pro Arg Gly Met 
            260                 265                 270         


Ala Arg Leu Ala Arg Asn Trp Gly Glu Glu Glu Ile Gln Thr Tyr Phe 
        275                 280                 285             


Val Val Asp Val Ala Ala Ser Val Lys Glu Val Ala Lys Ala Ala Val 
    290                 295                 300                 


Ser Ala Ala Gln Ala Phe Asp Pro Pro Arg Gln Val Ser Gly Arg Ser 
305                 310                 315                 320 


Leu Ser Pro Lys Val Gly Phe Ala Leu Ala Glu His Leu Glu Arg Val 
                325                 330                 335     


Thr Gly Ser Lys Arg Cys Ser Phe Asp Pro Ala Ala Gly Pro Ser Val 
            340                 345                 350         


Leu Ala Leu His Asp Glu Val Lys Lys Thr Tyr Lys Arg Leu Cys Ala 
        355                 360                 365             


Arg Gly Lys Asn Ala Ala Arg Ala Phe Pro Ala Asp Lys Thr Glu Leu 
    370                 375                 380                 


Leu Ala Leu Met Arg His Thr His Glu Asn Arg Val Arg Asn Gln Met 
385                 390                 395                 400 


Val Arg Met Gly Arg Val Ser Glu Tyr Arg Gly Gln Gln Ala Gly Asp 
                405                 410                 415     


Leu Ala Gln Ser His Tyr Trp Thr Ser Ala Gly Gln Thr Glu Ile Lys 
            420                 425                 430         


Glu Ser Glu Ile Phe Val Arg Leu Trp Val Gly Ala Phe Ala Leu Ala 
        435                 440                 445             


Gly Arg Ser Met Lys Ala Trp Ile Asp Pro Met Gly Lys Ile Val Asn 
    450                 455                 460                 


Thr Glu Lys Asn Asp Arg Asp Leu Thr Ala Ala Val Asn Ile Arg Gln 
465                 470                 475                 480 


Val Ile Ser Asn Lys Glu Met Val Ala Glu Ala Met Ala Arg Arg Gly 
                485                 490                 495     


Ile Tyr Phe Gly Glu Thr Pro Glu Leu Asp Arg Leu Gly Ala Glu Gly 
            500                 505                 510         


Asn Glu Gly Phe Val Phe Ala Leu Leu Arg Tyr Leu Arg Gly Cys Arg 
        515                 520                 525             


Asn Gln Thr Phe His Leu Gly Ala Arg Ala Gly Phe Leu Lys Glu Ile 
    530                 535                 540                 


Arg Lys Glu Leu Glu Lys Thr Arg Trp Gly Lys Ala Lys Glu Ala Glu 
545                 550                 555                 560 


His Val Val Leu Thr Asp Lys Thr Val Ala Ala Ile Arg Ala Ile Ile 
                565                 570                 575     


Asp Asn Asp Ala Lys Ala Leu Gly Ala Arg Leu Leu Ala Asp Leu Ser 
            580                 585                 590         


Gly Ala Phe Val Ala His Tyr Ala Ser Lys Glu His Phe Ser Thr Leu 
        595                 600                 605             


Tyr Ser Glu Ile Val Lys Ala Val Lys Asp Ala Pro Glu Val Ser Ser 
    610                 615                 620                 


Gly Leu Pro Arg Leu Lys Leu Leu Leu Lys Arg Ala Asp Gly Val Arg 
625                 630                 635                 640 


Gly Tyr Val His Gly Leu Arg Asp Thr Arg Lys His Ala Phe Ala Thr 
                645                 650                 655     


Lys Leu Pro Pro Pro Pro Ala Pro Arg Glu Leu Asp Asp Pro Ala Thr 
            660                 665                 670         


Lys Ala Arg Tyr Ile Ala Leu Leu Arg Leu Tyr Asp Gly Pro Phe Arg 
        675                 680                 685             


Ala Tyr Ala Ser Gly Ile Thr Gly Thr Ala Leu Ala Gly Pro Ala Ala 
    690                 695                 700                 


Arg Ala Lys Glu Ala Ala Thr Ala Leu Ala Gln Ser Val Asn Val Thr 
705                 710                 715                 720 


Lys Ala Tyr Ser Asp Val Met Glu Gly Arg Thr Ser Arg Leu Arg Pro 
                725                 730                 735     


Pro Asn Asp Gly Glu Thr Leu Arg Glu Tyr Leu Ser Ala Leu Thr Gly 
            740                 745                 750         


Glu Thr Ala Thr Glu Phe Arg Val Gln Ile Gly Tyr Glu Ser Asp Ser 
        755                 760                 765             


Glu Asn Ala Arg Lys Gln Ala Glu Phe Ile Glu Asn Tyr Arg Arg Asp 
    770                 775                 780                 


Met Leu Ala Phe Met Phe Glu Asp Tyr Ile Arg Ala Lys Gly Phe Asp 
785                 790                 795                 800 


Trp Ile Leu Lys Ile Glu Pro Gly Ala Thr Ala Met Thr Arg Ala Pro 
                805                 810                 815     


Val Leu Pro Glu Pro Ile Asp Thr Arg Gly Gln Tyr Glu His Trp Gln 
            820                 825                 830         


Ala Ala Leu Tyr Leu Val Met His Phe Val Pro Ala Ser Asp Val Ser 
        835                 840                 845             


Asn Leu Leu His Gln Leu Arg Lys Trp Glu Ala Leu Gln Gly Lys Tyr 
    850                 855                 860                 


Glu Leu Val Gln Asp Gly Asp Ala Thr Asp Gln Ala Asp Ala Arg Arg 
865                 870                 875                 880 


Glu Ala Leu Asp Leu Val Lys Arg Phe Arg Asp Val Leu Val Leu Phe 
                885                 890                 895     


Leu Lys Thr Gly Glu Ala Arg Phe Glu Gly Arg Ala Ala Pro Phe Asp 
            900                 905                 910         


Leu Lys Pro Phe Arg Ala Leu Phe Ala Asn Pro Ala Thr Phe Asp Arg 
        915                 920                 925             


Leu Phe Met Ala Thr Pro Thr Thr Ala Arg Pro Ala Glu Asp Asp Pro 
    930                 935                 940                 


Glu Gly Asp Gly Ala Ser Glu Pro Glu Leu Arg Val Ala Arg Thr Leu 
945                 950                 955                 960 


Arg Gly Leu Arg Gln Ile Ala Arg Tyr Asn His Met Ala Val Leu Ser 
                965                 970                 975     


Asp Leu Phe Ala Lys His Lys Val Arg Asp Glu Glu Val Ala Arg Leu 
            980                 985                 990         


Ala Glu Ile Glu Asp Glu Thr Gln  Glu Lys Ser Gln Ile  Val Ala Ala 
        995                 1000                 1005             


Gln Glu  Leu Arg Thr Asp Leu  His Asp Lys Val Met  Lys Cys His 
    1010                 1015                 1020             


Pro Lys  Thr Ile Ser Pro Glu  Glu Arg Gln Ser Tyr  Ala Ala Ala 
    1025                 1030                 1035             


Ile Lys  Thr Ile Glu Glu His  Arg Phe Leu Val Gly  Arg Val Tyr 
    1040                 1045                 1050             


Leu Gly  Asp His Leu Arg Leu  His Arg Leu Met Met  Asp Val Ile 
    1055                 1060                 1065             


Gly Arg  Leu Ile Asp Tyr Ala  Gly Ala Tyr Glu Arg  Asp Thr Gly 
    1070                 1075                 1080             


Thr Phe  Leu Ile Asn Ala Ser  Lys Gln Leu Gly Ala  Gly Ala Asp 
    1085                 1090                 1095             


Trp Ala  Val Thr Ile Ala Gly  Ala Ala Asn Thr Asp  Ala Arg Thr 
    1100                 1105                 1110             


Gln Thr  Arg Lys Asp Leu Ala  His Phe Asn Val Leu  Asp Arg Ala 
    1115                 1120                 1125             


Asp Gly  Thr Pro Asp Leu Thr  Ala Leu Val Asn Arg  Ala Arg Glu 
    1130                 1135                 1140             


Met Met  Ala Tyr Asp Arg Lys  Arg Lys Asn Ala Val  Pro Arg Ser 
    1145                 1150                 1155             


Ile Leu  Asp Met Leu Ala Arg  Leu Gly Leu Thr Leu  Lys Trp Gln 
    1160                 1165                 1170             


Met Lys  Asp His Leu Leu Gln  Asp Ala Thr Ile Thr  Gln Ala Ala 
    1175                 1180                 1185             


Ile Lys  His Leu Asp Lys Val  Arg Leu Thr Val Gly  Gly Pro Ala 
    1190                 1195                 1200             


Ala Val  Thr Glu Ala Arg Phe  Ser Gln Asp Tyr Leu  Gln Met Val 
    1205                 1210                 1215             


Ala Ala  Val Phe Asn Gly Ser  Val Gln Asn Pro Lys  Pro Arg Arg 
    1220                 1225                 1230             


Arg Asp  Asp Gly Asp Ala Trp  His Lys Pro Pro Lys  Pro Ala Thr 
    1235                 1240                 1245             


Ala Gln  Ser Gln Pro Asp Gln  Lys Pro Pro Asn Lys  Ala Pro Ser 
    1250                 1255                 1260             


Ala Gly  Ser Arg Leu Pro Pro  Pro Gln Val Gly Glu  Val Tyr Glu 
    1265                 1270                 1275             


Gly Val  Val Val Lys Val Ile  Asp Thr Gly Ser Leu  Gly Phe Leu 
    1280                 1285                 1290             


Ala Val  Glu Gly Val Ala Gly  Asn Ile Gly Leu His  Ile Ser Arg 
    1295                 1300                 1305             


Leu Arg  Arg Ile Arg Glu Asp  Ala Ile Ile Val Gly  Arg Arg Tyr 
    1310                 1315                 1320             


Arg Phe  Arg Val Glu Ile Tyr  Val Pro Pro Lys Ser  Asn Thr Ser 
    1325                 1330                 1335             


Lys Leu  Asn Ala Ala Asp Leu  Val Arg Ile Asp 
    1340                 1345                 


<210>  177
<211>  1349
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  177

Met Pro Leu Gln Ala Ala Gly Phe Gly Lys Pro Arg Arg Ser Pro Met 
1               5                   10                  15      


Arg Trp Leu Gln Ala Leu Ser Arg Pro Glu Arg Arg Lys Pro Gly Arg 
            20                  25                  30          


Trp Cys Gly Lys Ser Ala Arg Pro Asn Gly Thr Val Ala Asn Gly Leu 
        35                  40                  45              


Asp Gly Leu His Pro Cys Leu Gly Gly Phe Cys Ala Gly Gly Ala Thr 
    50                  55                  60                  


Met Gln Ile Gly Lys Val Gln Gly Arg Thr Ile Ser Glu Phe Gly Asp 
65                  70                  75                  80  


Pro Ala Gly Gly Leu Lys Arg Lys Ile Ser Thr Asp Gly Lys Asn Arg 
                85                  90                  95      


Lys Glu Leu Pro Ala His Leu Ser Ser Asp Pro Lys Ala Leu Ile Gly 
            100                 105                 110         


Gln Trp Ile Ser Gly Ile Asp Lys Ile Tyr Arg Lys Pro Asp Ser Arg 
        115                 120                 125             


Lys Ser Asp Gly Lys Ala Ile His Ser Pro Thr Pro Ser Lys Met Gln 
    130                 135                 140                 


Phe Asp Ala Arg Asp Asp Leu Gly Glu Ala Phe Trp Lys Leu Val Ser 
145                 150                 155                 160 


Glu Ala Gly Leu Ala Gln Asp Ser Asp Tyr Asp Gln Phe Lys Arg Arg 
                165                 170                 175     


Leu His Pro Tyr Gly Asp Lys Phe Gln Pro Ala Asp Ser Gly Ala Lys 
            180                 185                 190         


Leu Lys Phe Glu Ala Asp Pro Pro Glu Pro Gln Ala Phe His Gly Arg 
        195                 200                 205             


Trp Tyr Gly Ala Met Ser Lys Arg Gly Asn Asp Ala Lys Glu Leu Ala 
    210                 215                 220                 


Ala Ala Leu Tyr Glu His Leu His Val Asp Glu Lys Arg Ile Asp Gly 
225                 230                 235                 240 


Gln Pro Lys Arg Asn Pro Lys Thr Asp Lys Phe Ala Pro Gly Leu Val 
                245                 250                 255     


Val Ala Arg Ala Leu Gly Ile Glu Ser Ser Val Leu Pro Arg Gly Met 
            260                 265                 270         


Ala Arg Leu Ala Arg Asn Trp Gly Glu Glu Glu Ile Gln Thr Tyr Phe 
        275                 280                 285             


Val Val Asp Val Ala Ala Ser Val Lys Glu Val Ala Lys Ala Ala Val 
    290                 295                 300                 


Ser Ala Ala Gln Ala Phe Asp Pro Pro Arg Gln Val Ser Gly Arg Ser 
305                 310                 315                 320 


Leu Ser Pro Lys Val Gly Phe Ala Leu Ala Glu His Leu Glu Arg Val 
                325                 330                 335     


Thr Gly Ser Lys Arg Cys Ser Phe Asp Pro Ala Ala Gly Pro Ser Val 
            340                 345                 350         


Leu Ala Leu His Asp Glu Val Lys Lys Thr Tyr Lys Arg Leu Cys Ala 
        355                 360                 365             


Arg Gly Lys Asn Ala Ala Arg Ala Phe Pro Ala Asp Lys Thr Glu Leu 
    370                 375                 380                 


Leu Ala Leu Met Arg His Thr His Glu Asn Arg Val Arg Asn Gln Met 
385                 390                 395                 400 


Val Arg Met Gly Arg Val Ser Glu Tyr Arg Gly Gln Gln Ala Gly Asp 
                405                 410                 415     


Leu Ala Gln Ser His Tyr Trp Thr Ser Ala Gly Gln Thr Glu Ile Lys 
            420                 425                 430         


Glu Ser Glu Ile Phe Val Arg Leu Trp Val Gly Ala Phe Ala Leu Ala 
        435                 440                 445             


Gly Arg Ser Met Lys Ala Trp Ile Asp Pro Met Gly Lys Ile Val Asn 
    450                 455                 460                 


Thr Glu Lys Asn Asp Arg Asp Leu Thr Ala Ala Val Asn Ile Arg Gln 
465                 470                 475                 480 


Val Ile Ser Asn Lys Glu Met Val Ala Glu Ala Met Ala Arg Arg Gly 
                485                 490                 495     


Ile Tyr Phe Gly Glu Thr Pro Glu Leu Asp Arg Leu Gly Ala Glu Gly 
            500                 505                 510         


Asn Glu Gly Phe Val Phe Ala Leu Leu Arg Tyr Leu Arg Gly Cys Arg 
        515                 520                 525             


Asn Gln Thr Phe His Leu Gly Ala Arg Ala Gly Phe Leu Lys Glu Ile 
    530                 535                 540                 


Arg Lys Glu Leu Glu Lys Thr Arg Trp Gly Lys Ala Lys Glu Ala Glu 
545                 550                 555                 560 


His Val Val Leu Thr Asp Lys Thr Val Ala Ala Ile Arg Ala Ile Ile 
                565                 570                 575     


Asp Asn Asp Ala Lys Ala Leu Gly Ala Arg Leu Leu Ala Asp Leu Ser 
            580                 585                 590         


Gly Ala Phe Val Ala His Tyr Ala Ser Lys Glu His Phe Ser Thr Leu 
        595                 600                 605             


Tyr Ser Glu Ile Val Lys Ala Val Lys Asp Ala Pro Glu Val Ser Ser 
    610                 615                 620                 


Gly Leu Pro Arg Leu Lys Leu Leu Leu Lys Arg Ala Asp Gly Val Arg 
625                 630                 635                 640 


Gly Tyr Val His Gly Leu Arg Asp Thr Arg Lys His Ala Phe Ala Thr 
                645                 650                 655     


Lys Leu Pro Pro Pro Pro Ala Pro Arg Glu Leu Asp Asp Pro Ala Thr 
            660                 665                 670         


Lys Ala Arg Tyr Ile Ala Leu Leu Arg Leu Tyr Asp Gly Pro Phe Arg 
        675                 680                 685             


Ala Tyr Ala Ser Gly Ile Thr Gly Thr Ala Leu Ala Gly Pro Ala Ala 
    690                 695                 700                 


Arg Ala Lys Glu Ala Ala Thr Ala Leu Ala Gln Ser Val Asn Val Thr 
705                 710                 715                 720 


Lys Ala Tyr Ser Asp Val Met Glu Gly Arg Ser Ser Arg Leu Arg Pro 
                725                 730                 735     


Pro Asn Asp Gly Glu Thr Leu Arg Glu Tyr Leu Ser Ala Leu Thr Gly 
            740                 745                 750         


Glu Thr Ala Thr Glu Phe Arg Val Gln Ile Gly Tyr Glu Ser Asp Ser 
        755                 760                 765             


Glu Asn Ala Arg Lys Gln Ala Glu Phe Ile Glu Asn Tyr Arg Arg Asp 
    770                 775                 780                 


Met Leu Ala Phe Met Phe Glu Asp Tyr Ile Arg Ala Lys Gly Phe Asp 
785                 790                 795                 800 


Trp Ile Leu Lys Ile Glu Pro Gly Ala Thr Ala Met Thr Arg Ala Pro 
                805                 810                 815     


Val Leu Pro Glu Pro Ile Asp Thr Arg Gly Gln Tyr Glu His Trp Gln 
            820                 825                 830         


Ala Ala Leu Tyr Leu Val Met His Phe Val Pro Ala Ser Asp Val Ser 
        835                 840                 845             


Asn Leu Leu His Gln Leu Arg Lys Trp Glu Ala Leu Gln Gly Lys Tyr 
    850                 855                 860                 


Glu Leu Val Gln Asp Gly Asp Ala Thr Asp Gln Ala Asp Ala Arg Arg 
865                 870                 875                 880 


Glu Ala Leu Asp Leu Val Lys Arg Phe Arg Asp Val Leu Val Leu Phe 
                885                 890                 895     


Leu Lys Thr Gly Glu Ala Arg Phe Glu Gly Arg Ala Ala Pro Phe Asp 
            900                 905                 910         


Leu Lys Pro Phe Arg Ala Leu Phe Ala Asn Pro Ala Thr Phe Asp Arg 
        915                 920                 925             


Leu Phe Met Ala Thr Pro Thr Thr Ala Arg Pro Ala Glu Asp Asp Pro 
    930                 935                 940                 


Glu Gly Asp Gly Ala Ser Glu Pro Glu Leu Arg Val Ala Arg Thr Leu 
945                 950                 955                 960 


Arg Gly Leu Arg Gln Ile Ala Arg Tyr Asn His Met Ala Val Leu Ser 
                965                 970                 975     


Asp Leu Phe Ala Lys His Lys Val Arg Asp Glu Glu Val Ala Arg Leu 
            980                 985                 990         


Ala Glu Ile Glu Asp Glu Thr Gln  Glu Lys Ser Gln Ile  Val Ala Ala 
        995                 1000                 1005             


Gln Glu  Leu Arg Thr Asp Leu  His Asp Lys Val Met  Lys Cys His 
    1010                 1015                 1020             


Pro Lys  Thr Ile Ser Pro Glu  Glu Arg Gln Ser Tyr  Ala Ala Ala 
    1025                 1030                 1035             


Ile Lys  Thr Ile Glu Glu His  Arg Phe Leu Val Gly  Arg Val Tyr 
    1040                 1045                 1050             


Leu Gly  Asp His Leu Arg Leu  His Arg Leu Met Met  Asp Val Ile 
    1055                 1060                 1065             


Gly Arg  Leu Ile Asp Tyr Ala  Gly Ala Tyr Glu Arg  Asp Thr Gly 
    1070                 1075                 1080             


Thr Phe  Leu Ile Asn Ala Ser  Lys Gln Leu Gly Ala  Gly Ala Asp 
    1085                 1090                 1095             


Trp Ala  Val Thr Ile Ala Gly  Ala Ala Asn Thr Asp  Ala Arg Thr 
    1100                 1105                 1110             


Gln Thr  Arg Lys Asp Leu Ala  His Phe Asn Val Leu  Asp Arg Ala 
    1115                 1120                 1125             


Asp Gly  Thr Pro Asp Leu Thr  Ala Leu Val Asn Arg  Ala Arg Glu 
    1130                 1135                 1140             


Met Met  Ala Tyr Asp Arg Lys  Arg Lys Asn Ala Val  Pro Arg Ser 
    1145                 1150                 1155             


Ile Leu  Asp Met Leu Ala Arg  Leu Gly Leu Thr Leu  Lys Trp Gln 
    1160                 1165                 1170             


Met Lys  Asp His Leu Leu Gln  Asp Ala Thr Ile Thr  Gln Ala Ala 
    1175                 1180                 1185             


Ile Lys  His Leu Asp Lys Val  Arg Leu Thr Val Gly  Gly Pro Ala 
    1190                 1195                 1200             


Ala Val  Thr Glu Ala Arg Phe  Ser Gln Asp Tyr Leu  Gln Met Val 
    1205                 1210                 1215             


Ala Ala  Val Phe Asn Gly Ser  Val Gln Asn Pro Lys  Pro Arg Arg 
    1220                 1225                 1230             


Arg Asp  Asp Gly Asp Ala Trp  His Lys Pro Pro Lys  Pro Ala Thr 
    1235                 1240                 1245             


Ala Gln  Ser Gln Pro Asp Gln  Lys Pro Pro Asn Lys  Ala Pro Ser 
    1250                 1255                 1260             


Ala Gly  Ser Arg Leu Pro Pro  Pro Gln Val Gly Glu  Val Tyr Glu 
    1265                 1270                 1275             


Gly Val  Val Val Lys Val Ile  Asp Thr Gly Ser Leu  Gly Phe Leu 
    1280                 1285                 1290             


Ala Val  Glu Gly Val Ala Gly  Asn Ile Gly Leu His  Ile Ser Arg 
    1295                 1300                 1305             


Leu Arg  Arg Ile Arg Glu Asp  Ala Ile Ile Val Gly  Arg Arg Tyr 
    1310                 1315                 1320             


Arg Phe  Arg Val Glu Ile Tyr  Val Pro Pro Lys Ser  Asn Thr Ser 
    1325                 1330                 1335             


Lys Leu  Asn Ala Ala Asp Leu  Val Arg Ile Asp 
    1340                 1345                 


<210>  178
<211>  1349
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  178

Met Pro Leu Gln Ala Ala Gly Phe Gly Lys Pro Arg Arg Ser Pro Met 
1               5                   10                  15      


Arg Trp Leu Gln Ala Leu Ser Arg Pro Glu Arg Arg Lys Pro Gly Arg 
            20                  25                  30          


Trp Cys Gly Lys Ser Ala Arg Pro Asn Gly Thr Val Ala Asn Gly Leu 
        35                  40                  45              


Asp Gly Leu His Pro Cys Leu Gly Gly Phe Cys Ala Gly Gly Ala Thr 
    50                  55                  60                  


Met Gln Ile Gly Lys Val Gln Gly Arg Thr Ile Ser Glu Phe Gly Asp 
65                  70                  75                  80  


Pro Ala Gly Gly Leu Lys Arg Lys Ile Ser Thr Asp Gly Lys Asn Arg 
                85                  90                  95      


Lys Glu Leu Pro Ala His Leu Ser Ser Asp Pro Lys Ala Leu Ile Gly 
            100                 105                 110         


Gln Trp Ile Ser Gly Ile Asp Lys Ile Tyr Arg Lys Pro Asp Ser Arg 
        115                 120                 125             


Lys Ser Asp Gly Lys Ala Ile His Ser Pro Thr Pro Ser Lys Met Gln 
    130                 135                 140                 


Phe Asp Ala Arg Asp Asp Leu Gly Glu Ala Phe Trp Lys Leu Val Ser 
145                 150                 155                 160 


Glu Ala Gly Leu Ala Gln Asp Ser Asp Tyr Asp Gln Phe Lys Arg Arg 
                165                 170                 175     


Leu His Pro Tyr Gly Asp Lys Phe Gln Pro Ala Asp Ser Gly Ala Lys 
            180                 185                 190         


Leu Lys Phe Glu Ala Asp Pro Pro Glu Pro Gln Ala Phe His Gly Arg 
        195                 200                 205             


Trp Tyr Gly Ala Met Ser Lys Arg Gly Asn Asp Ala Lys Glu Leu Ala 
    210                 215                 220                 


Ala Ala Leu Tyr Glu His Leu His Val Asp Glu Lys Arg Ile Asp Gly 
225                 230                 235                 240 


Gln Pro Lys Arg Asn Pro Lys Thr Asp Lys Phe Ala Pro Gly Leu Val 
                245                 250                 255     


Val Ala Arg Ala Leu Gly Ile Glu Ser Ser Val Leu Pro Arg Gly Met 
            260                 265                 270         


Ala Arg Leu Ala Arg Asn Trp Gly Glu Glu Glu Ile Gln Thr Tyr Phe 
        275                 280                 285             


Val Val Asp Val Ala Ala Ser Val Lys Glu Val Ala Lys Ala Ala Val 
    290                 295                 300                 


Ser Ala Ala Gln Ala Phe Asp Pro Pro Arg Gln Val Ser Gly Arg Ser 
305                 310                 315                 320 


Leu Ser Pro Lys Val Gly Phe Ala Leu Ala Glu His Leu Glu Arg Val 
                325                 330                 335     


Thr Gly Ser Lys Arg Cys Ser Phe Asp Pro Ala Ala Gly Pro Ser Val 
            340                 345                 350         


Leu Ala Leu His Asp Glu Val Lys Lys Thr Tyr Lys Arg Leu Cys Ala 
        355                 360                 365             


Arg Gly Lys Asn Ala Ala Arg Ala Phe Pro Ala Asp Lys Thr Glu Leu 
    370                 375                 380                 


Leu Ala Leu Met Arg His Thr His Glu Asn Arg Val Arg Asn Gln Met 
385                 390                 395                 400 


Val Arg Met Gly Arg Val Ser Glu Tyr Arg Gly Gln Gln Ala Gly Asp 
                405                 410                 415     


Leu Ala Gln Ser His Tyr Trp Thr Ser Ala Gly Gln Thr Glu Ile Lys 
            420                 425                 430         


Glu Ser Glu Ile Phe Val Arg Leu Trp Val Gly Ala Phe Ala Leu Ala 
        435                 440                 445             


Gly Arg Ser Met Lys Ala Trp Ile Asp Pro Met Gly Lys Ile Val Asn 
    450                 455                 460                 


Thr Glu Lys Asn Asp Arg Asp Leu Thr Ala Ala Val Asn Ile Arg Gln 
465                 470                 475                 480 


Val Ile Ser Asn Lys Glu Met Val Ala Glu Ala Met Ala Arg Arg Gly 
                485                 490                 495     


Ile Tyr Phe Gly Glu Thr Pro Glu Leu Asp Arg Leu Gly Ala Glu Gly 
            500                 505                 510         


Asn Glu Gly Phe Val Phe Ala Leu Leu Arg Tyr Leu Arg Gly Cys Arg 
        515                 520                 525             


Asn Gln Thr Phe His Leu Gly Ala Arg Ala Gly Phe Leu Lys Glu Ile 
    530                 535                 540                 


Arg Lys Glu Leu Glu Lys Thr Arg Trp Gly Lys Ala Lys Glu Ala Glu 
545                 550                 555                 560 


His Val Val Leu Thr Asp Lys Thr Val Ala Ala Ile Arg Ala Ile Ile 
                565                 570                 575     


Asp Asn Asp Ala Lys Ala Leu Gly Ala Arg Leu Leu Ala Asp Leu Ser 
            580                 585                 590         


Gly Ala Phe Val Ala His Tyr Ala Ser Lys Glu His Phe Ser Thr Leu 
        595                 600                 605             


Tyr Ser Glu Ile Val Lys Ala Val Lys Asp Ala Pro Glu Val Ser Ser 
    610                 615                 620                 


Gly Leu Pro Arg Leu Lys Leu Leu Leu Lys Arg Ala Asp Gly Val Arg 
625                 630                 635                 640 


Gly Tyr Val His Gly Leu Arg Asp Thr Arg Lys His Ala Phe Ala Thr 
                645                 650                 655     


Lys Leu Pro Pro Pro Pro Ala Pro Arg Glu Leu Asp Asp Pro Ala Thr 
            660                 665                 670         


Lys Ala Arg Tyr Ile Ala Leu Leu Arg Leu Tyr Asp Gly Pro Phe Arg 
        675                 680                 685             


Ala Tyr Ala Ser Gly Ile Thr Gly Thr Ala Leu Ala Gly Pro Ala Ala 
    690                 695                 700                 


Arg Ala Lys Glu Ala Ala Thr Ala Leu Ala Gln Ser Val Asn Val Thr 
705                 710                 715                 720 


Lys Ala Tyr Ser Asp Val Met Glu Gly Arg Ser Ser Arg Leu Arg Pro 
                725                 730                 735     


Pro Asn Asp Gly Glu Thr Leu Arg Glu Tyr Leu Ser Ala Leu Thr Gly 
            740                 745                 750         


Glu Thr Ala Thr Glu Phe Arg Val Gln Ile Gly Tyr Glu Ser Asp Ser 
        755                 760                 765             


Glu Asn Ala Arg Lys Gln Ala Glu Phe Ile Glu Asn Tyr Arg Arg Asp 
    770                 775                 780                 


Met Leu Ala Phe Met Phe Glu Asp Tyr Ile Arg Ala Lys Gly Phe Asp 
785                 790                 795                 800 


Trp Ile Leu Lys Ile Glu Pro Gly Ala Thr Ala Met Thr Arg Ala Pro 
                805                 810                 815     


Val Leu Pro Glu Pro Ile Asp Thr Arg Gly Gln Tyr Glu His Trp Gln 
            820                 825                 830         


Ala Ala Leu Tyr Leu Val Met His Phe Val Pro Ala Ser Asp Val Ser 
        835                 840                 845             


Asn Leu Leu His Gln Leu Arg Lys Trp Glu Ala Leu Gln Gly Lys Tyr 
    850                 855                 860                 


Glu Leu Val Gln Asp Gly Asp Ala Thr Asp Gln Ala Asp Ala Arg Arg 
865                 870                 875                 880 


Glu Ala Leu Asp Leu Val Lys Arg Phe Arg Asp Val Leu Val Leu Phe 
                885                 890                 895     


Leu Lys Thr Gly Glu Ala Arg Phe Glu Gly Arg Ala Ala Pro Phe Asp 
            900                 905                 910         


Leu Lys Pro Phe Arg Ala Leu Phe Ala Asn Pro Ala Thr Phe Asp Arg 
        915                 920                 925             


Leu Phe Met Ala Thr Pro Thr Thr Ala Arg Pro Ala Glu Asp Asp Pro 
    930                 935                 940                 


Glu Gly Asp Gly Ala Ser Glu Pro Glu Leu Arg Val Ala Arg Thr Leu 
945                 950                 955                 960 


Arg Gly Leu Arg Gln Ile Ala Arg Tyr Asn His Met Ala Val Leu Ser 
                965                 970                 975     


Asp Leu Phe Ala Lys His Lys Val Arg Asp Glu Glu Val Ala Arg Leu 
            980                 985                 990         


Ala Glu Ile Glu Asp Glu Thr Gln  Glu Lys Ser Gln Ile  Val Ala Ala 
        995                 1000                 1005             


Gln Glu  Leu Arg Thr Asp Leu  His Asp Lys Val Met  Lys Cys His 
    1010                 1015                 1020             


Pro Lys  Thr Ile Ser Pro Glu  Glu Arg Gln Ser Tyr  Ala Ala Ala 
    1025                 1030                 1035             


Ile Lys  Thr Ile Glu Glu His  Arg Phe Leu Val Gly  Arg Val Tyr 
    1040                 1045                 1050             


Leu Gly  Asp His Leu Arg Leu  His Arg Leu Met Met  Asp Val Ile 
    1055                 1060                 1065             


Gly Arg  Leu Ile Asp Tyr Ala  Gly Ala Tyr Glu Arg  Asp Thr Gly 
    1070                 1075                 1080             


Thr Phe  Leu Ile Asn Ala Ser  Lys Gln Leu Gly Ala  Gly Ala Asp 
    1085                 1090                 1095             


Trp Ala  Val Thr Ile Ala Gly  Ala Ala Asn Thr Asp  Ala Arg Thr 
    1100                 1105                 1110             


Gln Thr  Arg Lys Asp Leu Ala  His Phe Asn Val Leu  Asp Arg Ala 
    1115                 1120                 1125             


Asp Gly  Thr Pro Asp Leu Thr  Ala Leu Val Asn Arg  Ala Arg Glu 
    1130                 1135                 1140             


Met Met  Ala Tyr Asp Arg Lys  Arg Lys Asn Ala Val  Pro Arg Ser 
    1145                 1150                 1155             


Ile Leu  Asp Met Leu Ala Arg  Leu Gly Leu Thr Leu  Lys Trp Gln 
    1160                 1165                 1170             


Met Lys  Asp His Leu Leu Gln  Asp Ala Thr Ile Thr  Gln Ala Ala 
    1175                 1180                 1185             


Ile Lys  His Leu Asp Lys Val  Arg Leu Thr Val Gly  Gly Pro Ala 
    1190                 1195                 1200             


Ala Val  Thr Glu Ala Arg Phe  Ser Gln Asp Tyr Leu  Gln Met Val 
    1205                 1210                 1215             


Ala Ala  Val Phe Asn Gly Ser  Val Gln Asn Pro Lys  Pro Arg Arg 
    1220                 1225                 1230             


Arg Asp  Asp Gly Asp Ala Trp  His Lys Pro Pro Lys  Pro Ala Thr 
    1235                 1240                 1245             


Ala Gln  Ser Gln Pro Asp Gln  Lys Pro Pro Asn Lys  Ala Pro Ser 
    1250                 1255                 1260             


Ala Gly  Ser Arg Leu Pro Pro  Pro Gln Val Gly Glu  Val Tyr Glu 
    1265                 1270                 1275             


Gly Val  Val Val Lys Val Ile  Asp Thr Gly Ser Leu  Gly Phe Leu 
    1280                 1285                 1290             


Ala Val  Glu Gly Val Ala Gly  Asn Ile Gly Leu His  Ile Ser Arg 
    1295                 1300                 1305             


Leu Arg  Arg Ile Arg Glu Asp  Ala Ile Ile Val Gly  Arg Arg Tyr 
    1310                 1315                 1320             


Arg Phe  Arg Val Glu Ile Tyr  Val Pro Pro Lys Ser  Asn Thr Ser 
    1325                 1330                 1335             


Lys Leu  Asn Ala Ala Asp Leu  Val Arg Ile Asp 
    1340                 1345                 


<210>  179
<211>  1380
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  179

Met Lys Leu Ser Lys Glu Lys Gln Ile Arg Ser Ala Val Ala Asn Lys 
1               5                   10                  15      


Glu Lys Asn Thr Glu Gly Val Leu Tyr Arg Phe Pro Gly Asp Asp Ile 
            20                  25                  30          


Gly Gly Val Gln Ala Gln Met Leu Val Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Leu Gly Asn Lys Pro Lys Glu 
    50                  55                  60                  


Trp Met Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Lys Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Ala Ile Asn Asp Ile Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Lys Glu Ala Asp Lys Lys Ile Arg Asn Met Ser Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Asn Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Ser Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Gly Asn Gln Glu Phe Asp Ser Ile Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Asp Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Ser Ile Gln Asp Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Ile Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Glu Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Asp Gly Leu Asn Glu Phe Met Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Glu Glu Lys Arg Ala Glu Val Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Ser His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Val Asn Lys Gly Lys Phe Tyr Val Trp 
305                 310                 315                 320 


Lys Lys His Glu Cys Gly Lys Lys Glu Asn Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Val Glu Ala Glu Ala Glu Ser Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Ile Phe Phe Glu Asn Asp Thr Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Thr Gly Thr Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Lys Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asn Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Gln Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Leu 
            660                 665                 670         


Val Arg Thr Val Phe Pro Glu Tyr Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Asn Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Arg Thr Leu Arg Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Lys 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Glu Asn Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Cys Ala Gln Asp 
            900                 905                 910         


Ile Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu 
        915                 920                 925             


Leu Ser Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Lys Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Lys Phe Ser Glu Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Thr Asn Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Gly  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Glu Lys Pro Glu  Glu Tyr Glu Lys Ile  Glu Ala Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Ile  Tyr Ala Pro Glu Lys  Asn Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Gln Gly Arg Val Gly  Ala Lys Val 
    1145                 1150                 1155             


Thr Ser  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Glu Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Met Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Val Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Val Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Glu Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asn Ala 
    1280                 1285                 1290             


Lys Asp  Lys Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Asp  Ala Glu Asp Ala Asp  Ser Lys Lys Pro Val  Ile Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Glu  Asp Glu Asp 
    1325                 1330                 1335             


Lys Gln  Lys Gly Lys Glu Asn  Arg Gly Lys Lys Asn  Thr Glu Thr 
    1340                 1345                 1350             


Arg Ser  Asp Ala Glu Lys Asn  Asn Asn Glu Arg Leu  Ser Tyr Asn 
    1355                 1360                 1365             


Pro Phe  Ala Asn Phe Asp Phe  Lys Leu Pro Asn Lys  
    1370                 1375                 1380 


<210>  180
<211>  1219
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  180

Met Lys Leu Thr Lys Ser Lys Asn Ala Lys Glu Ser Phe Phe Tyr Arg 
1               5                   10                  15      


Asn Ala Glu Lys Gly Lys Leu Tyr Ile His Asp Phe Leu Asn Glu Asp 
            20                  25                  30          


Ser Thr Asp Thr Val Ile Asp Gln Leu Pro Leu Asn Asp Ser Leu Ile 
        35                  40                  45              


Gly Arg Ile Leu Ser Lys Cys Asp Lys Thr Lys Ser Tyr Lys Gln Asn 
    50                  55                  60                  


Pro Phe Glu Lys Phe Ile Lys Asp Leu Val Val Ser Gly Thr Val Glu 
65                  70                  75                  80  


Leu Pro Thr Asn Lys Asp Ile Gly Phe Asn Lys Lys Phe Gln Ala Glu 
                85                  90                  95      


Lys Tyr Phe Ser His Tyr Gly Arg Ala Leu Lys Ile Val Lys Asp Gly 
            100                 105                 110         


Lys Thr Ile Glu Leu Met Asp Leu Leu Lys Glu Tyr Tyr Glu Asp Gly 
        115                 120                 125             


Lys Asn Ile Ser Glu Asp Leu Thr Ile Trp Ser Glu Thr Leu Lys Gly 
    130                 135                 140                 


Arg Val Val Tyr Lys Lys Lys Arg Leu Lys Lys Ser Ile Ser Asn Asn 
145                 150                 155                 160 


Lys Ile Phe Phe Pro Leu Asn Ile Asn Glu Ser Asn Asp Lys Lys Met 
                165                 170                 175     


Ser Lys Ala Gln Trp Leu Leu Gly Phe Ile Thr Asn Glu Glu Lys Phe 
            180                 185                 190         


Thr Lys Tyr Lys Asp Trp Tyr Asp Tyr Glu Ser Leu Tyr Glu Lys Leu 
        195                 200                 205             


Lys Pro Leu Lys Glu Lys Ala Asn Tyr Leu Lys Met Pro Gln Lys Trp 
    210                 215                 220                 


Gly Gly Cys Ile Tyr Ala Glu Val Gln Lys His His Arg Glu Leu Tyr 
225                 230                 235                 240 


Gln Lys Lys Lys Thr Glu Ala Leu Ser Thr Glu Glu Leu Gln Gly Phe 
                245                 250                 255     


Val Phe Tyr Leu Gly Glu Val Gln Ala Tyr Phe Arg His Tyr Phe Gly 
            260                 265                 270         


Ser Ser Lys Ala Gly Lys Ser Leu Asp Lys Glu Tyr Lys Val Asn Lys 
        275                 280                 285             


Leu Met Glu Val Lys Lys Gly Glu Leu Asp Glu Ser Tyr Leu Tyr Lys 
    290                 295                 300                 


Trp Ile Lys Ala His Ile Thr Asn Lys Ile Thr Ala Leu Leu Ile Gln 
305                 310                 315                 320 


Asn Gly Lys Leu Thr Gln Tyr Lys Val Ser Gln Pro Thr Ser Asp Asn 
                325                 330                 335     


Leu Ser Asn Ile Gln Ile Glu Glu Ser Phe Lys Lys Gln Leu Phe Leu 
            340                 345                 350         


Ser Ile Ala Trp Ala Thr Thr Arg Leu Asn Tyr Phe Phe Asp Tyr Gly 
        355                 360                 365             


Ser Asn Asn Asp Asp Leu Leu Gly Glu Pro Gln Asn Asn Ser Thr Ile 
    370                 375                 380                 


Gly Thr Thr Ile Thr Gly Asp Ile Leu Leu Glu Phe Asn Gln Asn Thr 
385                 390                 395                 400 


Thr Leu Lys Asp Ile Tyr Gln Lys Asn Gln Lys Asn Thr Thr Thr Tyr 
                405                 410                 415     


Ile Glu Tyr Phe Leu Ala Glu Leu Lys Glu Asn Lys Asn Asn Asn Lys 
            420                 425                 430         


Thr Val Phe Gln Glu Lys Ala Cys Thr Thr Phe Pro Ile Gln Ile Lys 
        435                 440                 445             


Lys Asp Asn Gln Asp Lys Ala Val Glu Asp Ile Leu Asp Val Leu Asp 
    450                 455                 460                 


Ala Ala Lys Glu Ser Ile Ser Tyr Leu Arg Asn Asn Ile Phe His Pro 
465                 470                 475                 480 


Gln Lys Glu Tyr Leu Tyr Glu Leu Thr Leu Pro Asp Lys Ile Lys Gly 
                485                 490                 495     


Ile Leu Glu His Asp Tyr Phe Ala Lys Val Lys Lys Val Leu Ala Thr 
            500                 505                 510         


Asp Ile Phe Arg Ile Asp Ser Cys Phe Lys Glu Lys Ile Arg Ser Ser 
        515                 520                 525             


Leu Ile Ala Asp Ile Tyr Pro Leu Glu Ile Leu Lys Lys Ile Phe Ser 
    530                 535                 540                 


Asp Cys Asn Leu Ala Phe His Ile Tyr Ala Pro Lys Tyr Glu Leu Met 
545                 550                 555                 560 


Pro Ala Phe Arg Lys Val Tyr Gln Arg Gly Thr Asn Leu Cys Ser Gln 
                565                 570                 575     


Asp Gly Thr Gln Arg Lys Leu Ser Trp Phe Tyr Asn Lys Pro Val Phe 
            580                 585                 590         


Asp Ser Glu Val Asp Val Ser Gln Glu Arg Asn Asp Ile Lys Lys Trp 
        595                 600                 605             


Gln Ala Tyr Lys Asn Leu Leu Gln Met Ile Tyr Glu His Ser Phe Leu 
    610                 615                 620                 


Pro Ala Val His Asp Asp Glu Ser Leu Ile Lys Lys Tyr Ile Asn Glu 
625                 630                 635                 640 


Thr Ile Lys Gln Ser Gln Glu Ala Ser Arg Ala Gly Asn Glu Tyr Cys 
                645                 650                 655     


Phe Arg Tyr Asn Asn Met Pro Lys His Asn Gly Leu Asn Leu Ala Glu 
            660                 665                 670         


Tyr Met Ala Glu Leu Gln Arg Leu Gln Ser Ala Glu Glu Ser Asn Gln 
        675                 680                 685             


His Asp Asn Ile Lys Asn Lys Thr Asp Asp Lys Asn Tyr Tyr Ile Asp 
    690                 695                 700                 


Phe Val Gln Asp Leu Phe Val Arg Ala Phe Asp His Tyr Leu Glu Lys 
705                 710                 715                 720 


His Leu Thr Asn Ile Lys Gly Gln Leu Phe Ser Thr Leu Ser Asn Asp 
                725                 730                 735     


Leu Ser Lys Ser Thr Glu Thr Thr Leu Asp Arg Leu Phe Gln Lys Asp 
            740                 745                 750         


Lys Pro Ile Thr Ser Met Gln His Asp Ser Phe Leu Ser Glu Asn Asp 
        755                 760                 765             


Asp Leu Cys Leu Leu Leu Tyr Pro Phe Leu Arg Met Leu Glu Arg Arg 
    770                 775                 780                 


Glu Leu Ser Asn Leu Gln His Gln Val Ile Arg Tyr Arg Cys Ser Leu 
785                 790                 795                 800 


Lys Asn Arg Arg Phe Glu Glu Met Lys Ser Ser Glu Lys Leu Glu Gln 
                805                 810                 815     


Leu Ile Ala Met Leu Ile Phe Thr Phe Pro Glu His Ile Asp Glu Glu 
            820                 825                 830         


Glu Cys Tyr Lys Asp Met Ile Glu Thr His Phe Lys Lys Leu Val Glu 
        835                 840                 845             


Gly Pro Ile Glu Thr Tyr Met Asp Leu Tyr Cys Gln Lys Glu Ala Val 
    850                 855                 860                 


Ser Gln Lys Val Ile Gln Gln Lys Ser Met Leu Ala Leu Met Arg Thr 
865                 870                 875                 880 


Gly Gly Met Ala Leu Tyr Ser Glu Met Phe Ser Ser Ile Tyr Lys Ile 
                885                 890                 895     


Thr Gln Lys Asp Tyr Asn Lys Tyr Lys Ser Tyr Arg Glu Leu Gly Glu 
            900                 905                 910         


Asn Thr Gly Asn Asn Gln Pro Ser Pro Ile Glu Lys Val Gln Gly Lys 
        915                 920                 925             


Leu Ala Ile Leu His Lys Glu Leu Cys Lys Glu Lys Ser Ile Phe Lys 
    930                 935                 940                 


Asn Asn Glu Lys Leu Lys Asp Tyr Glu Lys Lys Leu Thr Phe Val Asn 
945                 950                 955                 960 


Glu Tyr Ser Gly Leu Arg Arg Lys Ile Thr Phe Asp Leu Leu Tyr Glu 
                965                 970                 975     


Leu His Leu Ile His Val Asp Ile Leu Gly Arg Leu Ala Ser Phe Ala 
            980                 985                 990         


Ala Asp Trp Glu Arg Asp Met His  Phe Leu Leu Leu Gly  Leu Tyr Asn 
        995                 1000                 1005             


Leu Gly  Gln Gln Cys Gly Lys  Asp Ile Leu Thr Leu  Asn Glu Lys 
    1010                 1015                 1020             


Asn Ile  Glu Asp Ile Tyr Asp  His Lys Ile Gln Gly  Thr Met Thr 
    1025                 1030                 1035             


Thr Lys  Phe Leu Ala Ala Ile  Lys Glu Glu Thr Asn  Arg Lys Ile 
    1040                 1045                 1050             


Leu Thr  Gln Leu Tyr Phe Pro  Asn Asp Ser Leu Pro  Leu Ser Arg 
    1055                 1060                 1065             


Lys Lys  Leu Glu Glu Leu Ile  Arg Pro Arg Asn Ser  Leu Ala His 
    1070                 1075                 1080             


Leu Asn  His Met Thr Gln Leu  Lys Gln Gly Asn Ser  Tyr Gln Lys 
    1085                 1090                 1095             


Ser Ile  Ile Val Leu Leu Thr  Ala Val Gly Lys Leu  Leu Asn Tyr 
    1100                 1105                 1110             


Asp Leu  Lys Arg Lys Asn Ser  Val Thr Arg Val Leu  Lys Glu Leu 
    1115                 1120                 1125             


Leu Lys  Lys Tyr His Ile Asn  Leu Ser Leu Tyr Gln  Lys Ser Asp 
    1130                 1135                 1140             


Tyr Glu  Tyr Glu Leu Tyr Thr  Lys Glu Asp Cys Lys  Cys Asn His 
    1145                 1150                 1155             


Lys Arg  Pro Ser Ile Glu Ser  Glu Asn Ile Val His  Leu Lys Asp 
    1160                 1165                 1170             


Val Lys  Met Gly Gly Asp Lys  Lys Gly Ile Thr Ile  Pro Ala Lys 
    1175                 1180                 1185             


Asp Glu  Leu Phe Val Lys Cys  Ile Glu Lys Leu Leu  Ile Phe Ser 
    1190                 1195                 1200             


Tyr Asn  Glu Thr Glu Asp Lys  Lys Val Arg Asn Arg  Ser Thr His 
    1205                 1210                 1215             


Arg 
    


<210>  181
<211>  1101
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  181

Met Arg Ile Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Ile Tyr Ser Glu 
            20                  25                  30          


Gln Ala Val Ser Asn Glu Thr Asn Asn Ile Leu Pro Val Lys Lys Met 
        35                  40                  45              


Asp Ser Phe Asn Leu Ser Ile Leu Asn Lys Thr Ile Ile Lys Phe Glu 
    50                  55                  60                  


Thr Val Lys Lys Gln Lys Leu Asn Leu Asp Gln Tyr Lys Ile Val Glu 
65                  70                  75                  80  


Lys Ile Phe Lys Tyr Pro Lys Gln Glu Leu Pro Lys Gln Ile Asn Ala 
                85                  90                  95      


Glu Glu Ile Leu Gln Phe Leu Asn His Lys Phe Gln Glu Pro Val Lys 
            100                 105                 110         


Tyr Trp Lys Asn Gly Lys Glu Glu Ser Phe Asn Leu Thr Leu Leu Ile 
        115                 120                 125             


Val Glu Ala Val Lys Thr Gln Glu Lys Arg Lys Leu Gln Pro Tyr Tyr 
    130                 135                 140                 


Asp Trp Lys Thr Trp Tyr Ile Gln Thr Lys Ser Asp Leu Leu Lys Lys 
145                 150                 155                 160 


Ser Ile Glu Asn Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg 
                165                 170                 175     


Lys Lys Ala Leu Leu Ala Trp Glu Thr Glu Phe Thr Thr Ser Gly Ser 
            180                 185                 190         


Ile Asp Leu Thr His Phe His Lys Val Tyr Met Thr Asp Val Leu Cys 
        195                 200                 205             


Thr Ala Leu Gln Lys Val Glu Pro Ser Ala Asp Glu Arg Gly Lys Met 
    210                 215                 220                 


Asn Ser Asn Ala Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Asn His 
225                 230                 235                 240 


Gln Pro Ala Ile Phe Gly Thr Arg Glu Ala Pro Asn Glu Val Asn Arg 
                245                 250                 255     


Ala Asp Asn Gln Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu 
            260                 265                 270         


Glu His Tyr Phe Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Ala Asp 
        275                 280                 285             


Asp Ile Ser His Tyr Leu Lys Ala Gln Thr Leu Lys Thr Thr Ile Glu 
    290                 295                 300                 


Lys Gln Leu Val Asn Ala Ile Arg Ala Asn Ile Ile Gln Gln Gly Lys 
305                 310                 315                 320 


Thr Asn His His Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile 
                325                 330                 335     


Arg Ile Lys Thr Asn Glu Ala Phe Val Leu Asn Leu Ile Gly Thr Cys 
            340                 345                 350         


Ala Phe Ala Ala Asn Asn Ile Arg Asn Met Val Asp Lys Glu Gln Ile 
        355                 360                 365             


Ser Asp Ile Leu Gly Lys Arg Glu Phe Ile Asp Ser Leu Thr Lys Ser 
    370                 375                 380                 


Arg Ile Ser Ser Gln Leu Tyr Ser Phe Phe Phe Gly Glu Asn Leu Ser 
385                 390                 395                 400 


Thr Asn Lys Ala Glu Lys Glu Thr Gln Leu Trp Gly Ile Arg Gly Ala 
                405                 410                 415     


Val Gln Gln Ile Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu 
            420                 425                 430         


Thr Thr Ile Phe Asn Ile Cys Lys Phe Glu Asn Pro Thr Asp Ala Asp 
        435                 440                 445             


Pro Lys Gln Gln Thr Asn Tyr Val Asp Ser Ile Tyr Lys Thr Leu Phe 
    450                 455                 460                 


Ile Lys Glu Leu Glu Lys Ile Pro Glu Ala Phe Ala Gln Gln Leu Lys 
465                 470                 475                 480 


Thr Gly Gly Ala Leu Ser Tyr Tyr Thr Val Glu Asn Leu Lys Thr Leu 
                485                 490                 495     


Leu Thr Thr Phe Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala 
            500                 505                 510         


Pro Gly Phe Lys Lys Val Leu Asn Gly Gly Ile Asn Tyr Gln Asn Ala 
        515                 520                 525             


Lys Gln Asp Glu Ser Phe Tyr Glu Leu Met Leu Glu Arg Tyr Leu Arg 
    530                 535                 540                 


Lys Glu Asn Phe Ala Glu Glu Ala Tyr Asn Ala Arg Tyr Phe Leu Leu 
545                 550                 555                 560 


Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Lys Phe Thr Ala Asp Arg 
                565                 570                 575     


Lys Ala Phe Ala Asp Ser Val Gly Phe Val Gln Leu Gln Asn Arg Lys 
            580                 585                 590         


Gln Ala Glu Asn Ser Lys Arg Pro Lys Ala Phe Ala Phe Glu Ala Val 
        595                 600                 605             


Arg Pro Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala Tyr Val 
    610                 615                 620                 


Gln Ser Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys Ala Thr 
625                 630                 635                 640 


Asp Glu Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val Phe Ile 
                645                 650                 655     


Lys Gly Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe Val Gln 
            660                 665                 670         


Val Pro Gln Pro Gln Leu Thr Thr Thr Asp Ser Asn Gln Gln Lys Ala 
        675                 680                 685             


Asp Lys Leu Asn Gln Leu Glu Ala Ser Ile Thr Ala Asp Cys Lys Leu 
    690                 695                 700                 


Thr Ala Gln Tyr Ala Lys Thr Asp Asp Ala Thr His Ile Ala Phe Tyr 
705                 710                 715                 720 


Val Phe Cys Lys Leu Leu Asp Ala Gly His Leu Ser Asn Leu Arg Asn 
                725                 730                 735     


Glu Leu Ile Lys Phe Arg Gly Ser Val Lys Asp Phe Asp Phe His His 
            740                 745                 750         


Leu Leu Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val Val Pro 
        755                 760                 765             


Thr Asp Tyr Arg Asp Leu Tyr Ser Ser Gly Ala Asp Cys Leu Ala Arg 
    770                 775                 780                 


Leu Arg Pro Phe Ile Glu Gln Gly Ala Asp Ile Lys Asn Trp Ser Asp 
785                 790                 795                 800 


Leu Tyr Val Gln Thr Asp Lys Gln Thr Pro Val Ile His Ala Gly Ile 
                805                 810                 815     


Glu Leu Ser Val Lys Tyr Gly Thr Thr Ala Leu Leu Glu Gln Leu Ile 
            820                 825                 830         


Thr Cys Asn Pro Lys Phe Arg Val Met Glu Asp Asn Phe Thr Lys Trp 
        835                 840                 845             


Ser Ala Gln Lys Lys Glu Ile Glu Glu Lys Val Asn Lys His Thr Asn 
    850                 855                 860                 


Leu His Gln Gln Trp Val Glu Ala Lys Glu Lys Asp Asp Arg Glu Arg 
865                 870                 875                 880 


Val Lys Ser Lys Lys Asn Phe Val Arg Glu Tyr Val Lys Lys Asn Tyr 
                885                 890                 895     


Val Asp Tyr Ile Asn Asn Cys Ile Glu Ile Asn Asn Tyr Asn Trp Leu 
            900                 905                 910         


Asp Asn Lys Leu His Phe Val His Leu Asn His Leu His His Leu Thr 
        915                 920                 925             


Ile Asp Ile Leu Gly Arg Met Ala Gly Phe Val Ala Leu Trp Glu Arg 
    930                 935                 940                 


Asp Phe Gln Tyr Ile Thr Lys Tyr Thr Ala Ala Lys Glu Gly Thr Asp 
945                 950                 955                 960 


Ala Leu Ser Phe Asp Gly Gly Leu Pro Arg Leu Lys Asp Lys Gln Glu 
                965                 970                 975     


Tyr Tyr Asn Lys Leu Phe Leu Ser Asp Lys Tyr Thr Lys Val Arg Asn 
            980                 985                 990         


His Ile Ala His Phe Asn Tyr Leu  Thr Lys Asp Ala Ala  Asp Phe Ala 
        995                 1000                 1005             


Leu Leu  Asp Leu Ile Asn Glu  Leu Arg Glu Leu Leu  His Tyr Gly 
    1010                 1015                 1020             


Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ala Phe Ile  Asp Leu Phe 
    1025                 1030                 1035             


Glu Lys  His Gly Met Ile Leu  Lys Leu Lys Leu Asn  Thr Asp His 
    1040                 1045                 1050             


Gln Leu  Val Val Glu Ser Ile  Glu Pro Lys Lys Ile  Tyr His Leu 
    1055                 1060                 1065             


Gly Ser  Thr Ala Lys Asp Lys  Pro Glu Tyr Gln Tyr  Thr Thr Asn 
    1070                 1075                 1080             


Gln Val  Met Thr Val Tyr Cys  Asn Met Cys Arg Ser  Leu Leu Glu 
    1085                 1090                 1095             


Met Lys  Lys 
    1100     


<210>  182
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  182

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Ile Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Leu Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Phe Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Phe Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Arg Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Lys Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Glu 
        755                 760                 765             


Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Ile Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1400                 1405                 1410         


<210>  183
<211>  1349
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  183

Met Pro Leu Gln Ala Ala Gly Phe Gly Lys Pro Arg Arg Ser Pro Met 
1               5                   10                  15      


Arg Trp Leu Gln Ala Leu Ser Arg Pro Glu Arg Arg Lys Pro Gly Arg 
            20                  25                  30          


Trp Cys Gly Lys Ser Ala Arg Pro Asn Gly Thr Val Ala Asn Gly Leu 
        35                  40                  45              


Asp Gly Leu His Pro Cys Leu Gly Gly Phe Cys Ala Gly Gly Ala Thr 
    50                  55                  60                  


Met Gln Ile Gly Lys Val Gln Gly Arg Thr Ile Ser Glu Phe Gly Asp 
65                  70                  75                  80  


Pro Ala Gly Gly Leu Lys Arg Lys Ile Ser Thr Asp Gly Lys Asn Arg 
                85                  90                  95      


Lys Glu Leu Pro Ala His Leu Ser Ser Asp Pro Lys Ala Leu Ile Gly 
            100                 105                 110         


Gln Trp Ile Ser Gly Ile Asp Lys Ile Tyr Arg Lys Pro Asp Ser Arg 
        115                 120                 125             


Lys Ser Asp Gly Lys Ala Ile His Ser Pro Thr Pro Ser Lys Met Gln 
    130                 135                 140                 


Phe Asp Ala Arg Asp Asp Leu Gly Glu Ala Phe Trp Lys Leu Val Ser 
145                 150                 155                 160 


Glu Ala Gly Leu Ala Gln Asp Ser Asp Tyr Asp Gln Phe Lys Arg Arg 
                165                 170                 175     


Leu His Pro Tyr Gly Asp Lys Phe Gln Pro Ala Asp Ser Gly Ala Lys 
            180                 185                 190         


Leu Lys Phe Glu Ala Asp Pro Pro Glu Pro Gln Ala Phe His Gly Arg 
        195                 200                 205             


Trp Tyr Gly Ala Met Ser Lys Arg Gly Asn Asp Ala Lys Glu Leu Ala 
    210                 215                 220                 


Ala Ala Leu Tyr Glu His Leu His Val Asp Glu Lys Arg Ile Asp Gly 
225                 230                 235                 240 


Gln Pro Lys Arg Asn Pro Lys Thr Asp Lys Phe Ala Pro Gly Leu Val 
                245                 250                 255     


Val Ala Arg Ala Leu Gly Ile Glu Ser Ser Val Leu Pro Arg Gly Met 
            260                 265                 270         


Ala Arg Leu Ala Arg Asn Trp Gly Glu Glu Glu Ile Gln Thr Tyr Phe 
        275                 280                 285             


Val Val Asp Val Ala Ala Ser Val Lys Glu Val Ala Lys Ala Ala Val 
    290                 295                 300                 


Ser Ala Ala Gln Ala Phe Asp Pro Pro Arg Gln Val Ser Gly Arg Ser 
305                 310                 315                 320 


Leu Ser Pro Lys Val Gly Phe Ala Leu Ala Glu His Leu Glu Arg Val 
                325                 330                 335     


Thr Gly Ser Lys Arg Cys Ser Phe Asp Pro Ala Ala Gly Pro Ser Val 
            340                 345                 350         


Leu Ala Leu His Asp Glu Val Lys Lys Thr Tyr Lys Arg Leu Cys Ala 
        355                 360                 365             


Arg Gly Lys Asn Ala Ala Arg Ala Phe Pro Ala Asp Lys Thr Glu Leu 
    370                 375                 380                 


Leu Ala Leu Met Arg His Thr His Glu Asn Arg Val Arg Asn Gln Met 
385                 390                 395                 400 


Val Arg Met Gly Arg Val Ser Glu Tyr Arg Gly Gln Gln Ala Gly Asp 
                405                 410                 415     


Leu Ala Gln Ser His Tyr Trp Thr Ser Ala Gly Gln Thr Glu Ile Lys 
            420                 425                 430         


Glu Ser Glu Ile Phe Val Arg Leu Trp Val Gly Ala Phe Ala Leu Ala 
        435                 440                 445             


Gly Arg Ser Met Lys Ala Trp Ile Asp Pro Met Gly Lys Ile Val Asn 
    450                 455                 460                 


Thr Glu Lys Asn Asp Arg Asp Leu Thr Ala Ala Val Asn Ile Arg Gln 
465                 470                 475                 480 


Val Ile Ser Asn Lys Glu Met Val Ala Glu Ala Met Ala Arg Arg Gly 
                485                 490                 495     


Ile Tyr Phe Gly Glu Thr Pro Glu Leu Asp Arg Leu Gly Ala Glu Gly 
            500                 505                 510         


Asn Glu Gly Phe Val Phe Ala Leu Leu Arg Tyr Leu Arg Gly Cys Arg 
        515                 520                 525             


Asn Gln Thr Phe His Leu Gly Ala Arg Ala Gly Phe Leu Lys Glu Ile 
    530                 535                 540                 


Arg Lys Glu Leu Glu Lys Thr Arg Trp Gly Lys Ala Lys Glu Ala Glu 
545                 550                 555                 560 


His Val Val Leu Thr Asp Lys Thr Val Ala Ala Ile Arg Ala Ile Ile 
                565                 570                 575     


Asp Asn Asp Ala Lys Ala Leu Gly Ala Arg Leu Leu Ala Asp Leu Ser 
            580                 585                 590         


Gly Ala Phe Val Ala His Tyr Ala Ser Lys Glu His Phe Ser Thr Leu 
        595                 600                 605             


Tyr Ser Glu Ile Val Lys Ala Val Lys Asp Ala Pro Glu Val Ser Ser 
    610                 615                 620                 


Gly Leu Pro Arg Leu Lys Leu Leu Leu Lys Arg Ala Asp Gly Val Arg 
625                 630                 635                 640 


Gly Tyr Val His Gly Leu Arg Asp Thr Arg Lys His Ala Phe Ala Thr 
                645                 650                 655     


Lys Leu Pro Pro Pro Pro Ala Pro Arg Glu Leu Asp Asp Pro Ala Thr 
            660                 665                 670         


Lys Ala Arg Tyr Ile Ala Leu Leu Arg Leu Tyr Asp Gly Pro Phe Arg 
        675                 680                 685             


Ala Tyr Ala Ser Gly Ile Thr Gly Thr Ala Leu Ala Gly Pro Ala Ala 
    690                 695                 700                 


Arg Ala Lys Glu Ala Ala Thr Ala Leu Ala Gln Ser Val Asn Val Thr 
705                 710                 715                 720 


Lys Ala Tyr Ser Asp Val Met Glu Gly Arg Ser Ser Arg Leu Arg Pro 
                725                 730                 735     


Pro Asn Asp Gly Glu Thr Leu Arg Glu Tyr Leu Ser Ala Leu Thr Gly 
            740                 745                 750         


Glu Thr Ala Thr Glu Phe Arg Val Gln Ile Gly Tyr Glu Ser Asp Ser 
        755                 760                 765             


Glu Asn Ala Arg Lys Gln Ala Glu Phe Ile Glu Asn Tyr Arg Arg Asp 
    770                 775                 780                 


Met Leu Ala Phe Met Phe Glu Asp Tyr Ile Arg Ala Lys Gly Phe Asp 
785                 790                 795                 800 


Trp Ile Leu Lys Ile Glu Pro Gly Ala Thr Ala Met Thr Arg Ala Pro 
                805                 810                 815     


Val Leu Pro Glu Pro Ile Asp Thr Arg Gly Gln Tyr Glu His Trp Gln 
            820                 825                 830         


Ala Ala Leu Tyr Leu Val Met His Phe Val Pro Ala Ser Asp Val Ser 
        835                 840                 845             


Asn Leu Leu His Gln Leu Arg Lys Trp Glu Ala Leu Gln Gly Lys Tyr 
    850                 855                 860                 


Glu Leu Val Gln Asp Gly Asp Ala Thr Asp Gln Ala Asp Ala Arg Arg 
865                 870                 875                 880 


Glu Ala Leu Asp Leu Val Lys Arg Phe Arg Asp Val Leu Val Leu Phe 
                885                 890                 895     


Leu Lys Thr Gly Glu Ala Arg Phe Glu Gly Arg Ala Ala Pro Phe Asp 
            900                 905                 910         


Leu Lys Pro Phe Arg Ala Leu Phe Ala Asn Pro Ala Thr Phe Asp Arg 
        915                 920                 925             


Leu Phe Met Ala Thr Pro Thr Thr Ala Arg Pro Ala Glu Asp Asp Pro 
    930                 935                 940                 


Glu Gly Asp Gly Ala Ser Glu Pro Glu Leu Arg Val Ala Arg Thr Leu 
945                 950                 955                 960 


Arg Gly Leu Arg Gln Ile Ala Arg Tyr Asn His Met Ala Val Leu Ser 
                965                 970                 975     


Asp Leu Phe Ala Lys His Lys Val Arg Asp Glu Glu Val Ala Arg Leu 
            980                 985                 990         


Ala Glu Ile Glu Asp Glu Thr Gln  Glu Lys Ser Gln Ile  Val Ala Ala 
        995                 1000                 1005             


Gln Glu  Leu Arg Thr Asp Leu  His Asp Lys Val Met  Lys Cys His 
    1010                 1015                 1020             


Pro Lys  Thr Ile Ser Pro Glu  Glu Arg Gln Ser Tyr  Ala Ala Ala 
    1025                 1030                 1035             


Ile Lys  Thr Ile Glu Glu His  Arg Phe Leu Val Gly  Arg Val Tyr 
    1040                 1045                 1050             


Leu Gly  Asp His Leu Arg Leu  His Arg Leu Met Met  Asp Val Ile 
    1055                 1060                 1065             


Gly Arg  Leu Ile Asp Tyr Ala  Gly Ala Tyr Glu Arg  Asp Thr Gly 
    1070                 1075                 1080             


Thr Phe  Leu Ile Asn Ala Ser  Lys Gln Leu Gly Ala  Gly Ala Asp 
    1085                 1090                 1095             


Trp Ala  Val Thr Ile Ala Gly  Ala Ala Asn Thr Asp  Ala Arg Thr 
    1100                 1105                 1110             


Gln Thr  Arg Lys Asp Leu Ala  His Phe Asn Val Leu  Asp Arg Ala 
    1115                 1120                 1125             


Asp Gly  Thr Pro Asp Leu Thr  Ala Leu Val Asn Arg  Ala Arg Glu 
    1130                 1135                 1140             


Met Met  Ala Tyr Asp Arg Lys  Arg Lys Asn Ala Val  Pro Arg Ser 
    1145                 1150                 1155             


Ile Leu  Asp Met Leu Ala Arg  Leu Gly Leu Thr Leu  Lys Trp Gln 
    1160                 1165                 1170             


Met Lys  Asp His Leu Leu Gln  Asp Ala Thr Ile Thr  Gln Ala Ala 
    1175                 1180                 1185             


Ile Lys  His Leu Asp Lys Val  Arg Leu Thr Val Gly  Gly Pro Ala 
    1190                 1195                 1200             


Ala Val  Thr Glu Ala Arg Phe  Ser Gln Asp Tyr Leu  Gln Met Val 
    1205                 1210                 1215             


Ala Ala  Val Phe Asn Gly Ser  Val Gln Asn Pro Lys  Pro Arg Arg 
    1220                 1225                 1230             


Arg Asp  Asp Gly Asp Ala Trp  His Lys Pro Pro Lys  Pro Ala Thr 
    1235                 1240                 1245             


Ala Gln  Ser Gln Pro Asp Gln  Lys Pro Pro Asn Lys  Ala Pro Ser 
    1250                 1255                 1260             


Ala Gly  Ser Arg Leu Pro Pro  Pro Gln Val Gly Glu  Val Tyr Glu 
    1265                 1270                 1275             


Gly Val  Val Val Lys Val Ile  Asp Thr Gly Ser Leu  Gly Phe Leu 
    1280                 1285                 1290             


Ala Val  Glu Gly Val Ala Gly  Asn Ile Gly Leu His  Ile Ser Arg 
    1295                 1300                 1305             


Leu Arg  Arg Ile Arg Glu Asp  Ala Ile Ile Val Gly  Arg Arg Tyr 
    1310                 1315                 1320             


Arg Phe  Arg Val Glu Ile Tyr  Val Pro Pro Lys Ser  Asn Thr Ser 
    1325                 1330                 1335             


Lys Leu  Asn Ala Ala Asp Leu  Val Arg Ile Asp 
    1340                 1345                 


<210>  184
<211>  1137
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  184

Met Cys Met Lys Ile Thr Lys Ile Asp Gly Ile Ser His Lys Lys Tyr 
1               5                   10                  15      


Lys Glu Lys Gly Lys Leu Ile Lys Ser Asn Glu Ile Glu Lys Asp Val 
            20                  25                  30          


Thr Glu Glu Arg Phe Asn Asp Ile Glu Ala Lys Thr Thr Glu Leu Phe 
        35                  40                  45              


Leu Lys Thr Leu Asp Ser Tyr Val Lys Asn Tyr Glu Lys Cys Glu Glu 
    50                  55                  60                  


Gln Asn Lys Glu Arg Arg Glu Lys Ala Lys Asn Tyr Phe Ser Lys Val 
65                  70                  75                  80  


Lys Leu Ile Ile Asp Asn Glu Lys Ile Thr Ile Cys Asn Glu Asn Thr 
                85                  90                  95      


Glu Lys Ile Glu Ile Glu Asp Phe Asn Glu Tyr Asp Val Arg Asn Arg 
            100                 105                 110         


Lys Tyr Phe Asn Val Leu Asn Lys Ile Leu Asn Gly Glu Asn Tyr Thr 
        115                 120                 125             


Glu Glu Asp Leu Glu Val Phe Glu Asn Asp Leu Gln Lys Lys Leu Asn 
    130                 135                 140                 


Gln Ile Gln Ser Ile Lys Asn Ser Leu Glu Glu Asn Lys Ala His Phe 
145                 150                 155                 160 


Lys Lys Glu Ser Ile Asn Asn Thr Thr Asp Arg Val Lys Gly Asn Asn 
                165                 170                 175     


Lys Lys Ser Leu Phe Tyr Glu Tyr Tyr Arg Asn Ser Ser Lys His Gln 
            180                 185                 190         


Glu Tyr Val Asn Asn Ile Phe Glu Ala Phe Asp Lys Leu Tyr Ser Asn 
        195                 200                 205             


Ser His Glu Asp Ile Asn Asn Leu Phe Leu Glu Ile Thr Lys Asp Ser 
    210                 215                 220                 


Asn Asp Arg Asn Ile Arg Lys Ile Arg Glu Thr Tyr His Glu Ile Leu 
225                 230                 235                 240 


Asn Lys Asn Lys Thr Glu Phe Gly Glu Glu Leu Tyr Lys Lys Ile Gln 
                245                 250                 255     


Asp Asn Ile Asn Asn Phe Asp Lys Leu Leu Glu Ile Glu Pro Glu Ile 
            260                 265                 270         


Lys Glu Leu Thr Lys Ser Gln Ile Phe Tyr Lys Tyr Tyr Ile Asp Lys 
        275                 280                 285             


Val Ser Leu Asp Gly Thr Asn Ile Lys His Cys Phe Ser His Leu Val 
    290                 295                 300                 


Glu Ile Glu Val Asn Gln Leu Leu Lys Asn Tyr Val Tyr Ser Lys Arg 
305                 310                 315                 320 


Ser Thr Asn Lys Glu Lys Leu Glu Asn Ile Phe Glu Tyr Cys Lys Leu 
                325                 330                 335     


Arg Asn Leu Val Lys Asn Lys Leu Val Asn Lys Leu Asn Ser Tyr Ile 
            340                 345                 350         


Arg Asn Cys Gly Lys Tyr Asn Gly Tyr Ile Ser Asn Asn Asp Val Val 
        355                 360                 365             


Asn Ser Glu Lys Ile Ser Glu Ile Arg Thr Lys Glu Ala Phe Leu Arg 
    370                 375                 380                 


Ser Ile Ile Gly Val Ser Ser Ser Ala Tyr Phe Ser Leu Arg Asn Ile 
385                 390                 395                 400 


Leu Asn Thr Asp Asn Thr Gln Asp Ile Thr Asn Lys Val Asp Lys Glu 
                405                 410                 415     


Val Asp Lys Leu Tyr Gln Glu Asn Lys Lys Ile Glu Leu Glu Glu Arg 
            420                 425                 430         


Leu Lys Leu Phe Phe Gly Asn Tyr Phe Asp Ile Asn Asn Gln Gln Glu 
        435                 440                 445             


Ile Glu Asp Phe Leu Met Asn Ile Asp Lys Ile Ile Ser Ser Ile Arg 
    450                 455                 460                 


Asn Glu Ile Ile His Phe Lys Met Glu Ala Asn Ala Tyr Ser Ile Phe 
465                 470                 475                 480 


Asp Phe Asn Asn Val Thr Leu Gly Asn Lys Ala Lys Lys Ile Leu Asn 
                485                 490                 495     


Glu Glu Ile Asn Lys Glu Lys Ile Lys Leu Lys Ile Phe Lys Gln Leu 
            500                 505                 510         


Asn Ser Ala Asn Val Phe Asp Tyr Leu Ser Asn Glu Asp Ile Thr Glu 
        515                 520                 525             


Tyr Met Gly Lys Ala Val Phe Ser Phe Thr Asn Arg Asn Ile Pro Phe 
    530                 535                 540                 


Val Pro Ser Phe Thr Lys Ile Tyr Asn Arg Val Gln Asp Leu Ala Asn 
545                 550                 555                 560 


Ser Leu Lys Ile Glu Glu Trp Lys Ile Pro Glu Gly Ser Glu Lys Lys 
                565                 570                 575     


Asp Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu 
            580                 585                 590         


Asp Lys Phe Leu Asn Glu Glu Asn Gly Ile Phe Ile Ser Ile Lys Asn 
        595                 600                 605             


Lys Ile Ile Glu Leu Asn Arg Asn Gln Asn Lys Arg Thr Gly Phe Tyr 
    610                 615                 620                 


Lys Leu Glu Lys Phe Glu Lys Ile Glu Glu Lys Asn Pro Lys Lys Tyr 
625                 630                 635                 640 


Leu Glu Ile Ile Gln Ser Leu Tyr Met Ile Asn Ile Glu Glu Ile Asp 
                645                 650                 655     


Asn Glu Glu Lys Asn Ile Phe Leu Asp Phe Ile Gln Lys Ile Phe Leu 
            660                 665                 670         


Lys Gly Phe Phe Glu Phe Ile Lys Asn Asn Tyr Asn Tyr Leu Leu Glu 
        675                 680                 685             


Leu Lys Lys Val Gln Asp Lys Lys Asn Ile Phe Asp Arg Glu Met Ser 
    690                 695                 700                 


Glu Tyr Thr Thr Gly Glu Lys Thr Leu Glu Asp Met Glu Glu Ile Asn 
705                 710                 715                 720 


Glu Ile Thr Gln Lys Ile Lys Ile Thr Glu Ile Asp Lys Ile Leu Asn 
                725                 730                 735     


Gln Thr Asp Lys Ile Asn Cys Phe Tyr Leu Leu Leu Lys Leu Leu Asn 
            740                 745                 750         


Tyr Lys Glu Ile Thr Glu Leu Lys Gly Asn Leu Glu Lys Tyr Gln Ile 
        755                 760                 765             


Leu Ser Asn Thr Asn Ile Tyr Glu Lys Glu Leu Thr Leu Leu Asn Ile 
    770                 775                 780                 


Val Asn Leu Asp Asn Asn Lys Val Lys Ile Glu Asn Phe Glu Ile Ser 
785                 790                 795                 800 


Val Lys Glu Ile Gly Lys Phe Ile Glu Lys Ile Ser Gly Asn Arg Lys 
                805                 810                 815     


Ile Glu Thr Phe Glu Glu Leu Arg Asn Phe Glu Lys Ile Gly Asn Ser 
            820                 825                 830         


Val Glu Tyr Tyr Asn Val Tyr Ser Asp Asp Lys Asn Ile Lys Asn Ile 
        835                 840                 845             


Arg Asn Leu Tyr Asn Ile Lys Lys Tyr Gly Met Leu Asp Leu Leu Glu 
    850                 855                 860                 


Lys Ile Ser Glu Lys Ala Asn Tyr Cys Ile Lys Lys Lys Asn Leu Glu 
865                 870                 875                 880 


Glu Tyr Asn Glu Leu Lys Lys Gln Leu Glu Asp Glu Lys Thr Asp Phe 
                885                 890                 895     


Tyr Lys Ile Gln Lys Asp Leu His Tyr Lys Tyr Gln Lys Lys Tyr Lys 
            900                 905                 910         


Asn Phe Ser Glu Lys Asn Asn Ile Glu Asp Tyr Lys Lys Tyr Lys Lys 
        915                 920                 925             


Ser Ile Glu Asn Ile Glu Lys Tyr Val His Leu Lys Asn Lys Ile Glu 
    930                 935                 940                 


Phe Asn Glu Leu Asn Leu Leu Gln Ser Leu Leu Leu Lys Thr Leu His 
945                 950                 955                 960 


Arg Leu Val Gly Phe Thr Ser Ile Trp Glu Arg Asp Leu Arg Phe Arg 
                965                 970                 975     


Leu Thr Gly Glu Phe Pro Asn Glu Leu Asp Val Glu Asp Ile Phe Asp 
            980                 985                 990         


His Arg Lys Arg Tyr Arg Gly Asn  Lys Gly Gln Ile Cys  Lys Lys Tyr 
        995                 1000                 1005             


Asp Gln  Phe Ile Ser Val His  Ile Glu Tyr Gln Asn  Asn Asn Lys 
    1010                 1015                 1020             


Met Lys  Asn Ile Lys Phe Asp  Asp Asn Asn Pro Ile  Arg Asn Tyr 
    1025                 1030                 1035             


Ile Ala  His Phe Asn Tyr Leu  Pro Thr Pro Lys Tyr  Ser Ile Leu 
    1040                 1045                 1050             


Lys Met  Leu Glu Lys Leu Arg  Glu Leu Leu Asp Tyr  Asp Arg Lys 
    1055                 1060                 1065             


Leu Lys  Asn Ala Val Met Lys  Ser Ile Lys Gly Ile  Leu Glu Glu 
    1070                 1075                 1080             


Tyr Gly  Phe Glu Ala Glu Phe  Ile Ile Asn Pro Asn  Lys Glu Ile 
    1085                 1090                 1095             


Ile Leu  Asn Ser Ile Lys Ser  Ala Glu Ile Ile His  Leu Lys Lys 
    1100                 1105                 1110             


Asn Asp  Leu Lys Ser His Arg  Asn Ser Glu Asp Leu  Cys Lys Leu 
    1115                 1120                 1125             


Val Ile  Ala Met Leu Glu Tyr  Ser Lys 
    1130                 1135         


<210>  185
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  185

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Lys Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn Gln Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Ile Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Asn Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Val Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Phe Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Gln Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Lys Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ala Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asp Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Ile Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Met Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Glu  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Ala Gln Gly  Gly Ala Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Arg Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Lys Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Met Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Cys Ile  Ser Ser Ile Lys Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Thr Leu Ile Thr Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Ser Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Gly Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  186
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  186

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Thr Glu Asn Lys Asn Glu Glu Gln Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Arg Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Leu Lys Lys Asn Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Lys Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Cys Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Ile Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Gln Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Leu Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Ala Leu Glu Gly Glu Ser 
    450                 455                 460                 


Val Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Glu Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Ala Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Arg Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Lys Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Lys Gly Asp Lys Glu Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Glu Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Ser Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Lys Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Glu Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Val Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Thr Gln  
    1355                 1360 


<210>  187
<211>  1217
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  187

Met Arg Ile Thr Lys Val Lys Val Glu Ala Gly Glu Asn Gly Asn Pro 
1               5                   10                  15      


Gly Ser Asp Lys Gly Lys Met Val Phe Leu Gln Arg Glu Val Lys Lys 
            20                  25                  30          


Gly Ser Leu Val Leu Glu Gly Phe Ser Ser Gly Ala Ser Glu Ile Glu 
        35                  40                  45              


Gly Asp His Leu Ser Asp Arg Thr Thr Asp Ile Ile Gln Gln Tyr Lys 
    50                  55                  60                  


Asn Arg Ser Phe Gly Leu Ser Leu Leu Lys Gln Thr Val Ile Ser Lys 
65                  70                  75                  80  


Asp Lys Leu Gln Lys Val His Cys Glu Lys Cys Lys Gly Lys Lys Pro 
                85                  90                  95      


Cys Glu Ala Cys Lys Lys Lys Tyr Glu His Lys Lys Val Ile Cys Ser 
            100                 105                 110         


Thr Leu Glu Arg Ile Phe Lys Pro Val Ile Glu Asp Val Ile Tyr Gly 
        115                 120                 125             


Lys Arg Ile Asp Tyr Asp Tyr Glu Asn Ile Lys Phe Ser Ser Gln Leu 
    130                 135                 140                 


Ser Leu Cys Lys Glu Glu Leu Ser Asn Phe Leu Cys His Lys Phe Arg 
145                 150                 155                 160 


Asp Thr Leu Arg Tyr Asn Asp Val Leu Lys Val Arg Arg Glu Val Asn 
                165                 170                 175     


Leu Ile Asp Cys Leu Gly Lys Phe Ile Asp Ser Lys Gly Arg Met Glu 
            180                 185                 190         


Ser Leu Arg Ala Tyr Cys Asp Trp Ala Glu Ala Tyr Ile Val Arg Lys 
        195                 200                 205             


Lys Ala Met Leu Glu Lys Ser Val Gln Asn Asn Arg Ile Val Phe Asp 
    210                 215                 220                 


Tyr Ser Glu Thr Glu Thr Thr Gly Leu Ser Lys Arg Lys Gln Ala Leu 
225                 230                 235                 240 


Leu Lys Trp Gly Lys Asp Tyr Glu Asp Lys Ser Arg Ser Asn Gln Gly 
                245                 250                 255     


Ala Ile Ser Pro Ile Asp Ala Ala Ser Ser Val His Tyr Asn Ile Asn 
            260                 265                 270         


Leu Asp Asp Phe His Arg Ala Phe Lys Ile Asp Asp Leu Cys Asn Ala 
        275                 280                 285             


Phe Ala Leu Thr Leu Glu Lys Gln Leu Ala Leu Leu Lys Glu Gln Glu 
    290                 295                 300                 


Glu Gln Lys His Lys Gln Pro Asn Leu Gln Asn Thr Tyr Ser Ala His 
305                 310                 315                 320 


Asn Gln Pro Thr Glu Thr Lys Thr Lys Leu Val Leu Thr Ser Ser Val 
                325                 330                 335     


Cys Ala Leu Leu Lys Lys Thr Leu Gln Glu His Gln Ala Thr Trp Val 
            340                 345                 350         


Phe Gly Arg Gln Ala Asp Leu Glu Lys Glu Asn Val Asp Pro Ala Arg 
        355                 360                 365             


Asp Ala Phe Ile Lys His Arg Asn Asp Cys Gln Leu Tyr Ala Tyr Asn 
    370                 375                 380                 


Leu Glu Val Val Lys Tyr Leu Glu His Tyr Phe Pro Ile Lys Arg Lys 
385                 390                 395                 400 


Lys Pro Leu Pro Asp Glu Glu Ser Ala Arg Tyr Tyr Leu Asn Pro Glu 
                405                 410                 415     


Thr Ile Lys Lys Arg Ile Gln Phe Gln Leu Glu Asn Ala Val Arg Met 
            420                 425                 430         


Gln Leu Leu Gln Gln Gly Lys Leu Lys His His Glu Leu Asp Glu Arg 
        435                 440                 445             


Val Asn Ser Glu Thr Leu Ser Ser Ile Lys Arg Asp Asp Phe Phe Val 
    450                 455                 460                 


Leu Asn Leu Val Glu Ala Cys Ala Phe Ala Ala Ser Asn Ile Arg Asn 
465                 470                 475                 480 


Ile Ile Asp His Glu Gln Lys Lys Asp Ile Leu Gly Lys Val Asp Phe 
                485                 490                 495     


Lys Asn Ser Leu Ala Ser Ala Arg Phe Asp Gly Glu Leu Cys Lys Tyr 
            500                 505                 510         


Phe Tyr Glu Thr Asn Leu Lys Thr Asp Cys Gln Ala Leu Trp Ala Met 
        515                 520                 525             


Arg Gly Ala Val Gln Gln Ile Arg Asn Gly Ile Val His Tyr His Lys 
    530                 535                 540                 


Gly Leu Ile Glu Ser Val Phe Lys Leu Asp Thr Phe Glu Tyr Glu Asn 
545                 550                 555                 560 


Ala Val Asp Ser Glu Lys Gln Tyr Thr His Thr Val Phe Lys Glu Leu 
                565                 570                 575     


Leu Gln Lys Ser Leu Ala Lys Leu Asp Gly Tyr Ile Val Glu Gln Phe 
            580                 585                 590         


Arg Ser Asn Asp Val Leu Ser Tyr Tyr Glu Ala Ser Asp Leu Asn Lys 
        595                 600                 605             


Leu Phe Gly Glu Gln Ser Leu Ser Leu His Arg His Ser Ile Pro Phe 
    610                 615                 620                 


Ala Pro Gly Phe Lys Asn Ile Tyr Asp Ser Gly Ala Lys Leu Gln Gln 
625                 630                 635                 640 


Gly Ser Thr Gly Met Arg Leu Asn His Phe Leu Leu Ala Glu Asn Asn 
                645                 650                 655     


Glu Ala Ser Leu Thr Arg Glu Gly Lys Glu Leu Ser Phe Ser Arg Lys 
            660                 665                 670         


Leu Ser Pro Ala Ala Thr Lys Leu Ser Pro Ala Tyr Pro Ala Phe Arg 
        675                 680                 685             


Phe Leu Leu Lys Leu Ile Tyr Asn His Leu Phe Leu Asn Phe Phe Leu 
    690                 695                 700                 


Asn Ser Glu Asp Asn Ala Ser Phe Arg Asn Ala Val Ala Phe Val Leu 
705                 710                 715                 720 


Lys Asn Asn Arg Glu Glu Ala Met Gln Ala Leu Arg Glu Ser Ala Lys 
                725                 730                 735     


Lys His Pro Gly Ser Arg Ser Ser Lys Pro Leu Leu Pro Gln Lys Tyr 
            740                 745                 750         


Ala Phe Arg Glu Ile Arg Gly Val Gln Asn Gly Glu Asp Ile Ala Ser 
        755                 760                 765             


Tyr Met Ser Tyr Leu His Ser Phe Ser Val Gln Glu Gln Glu Arg Lys 
    770                 775                 780                 


Gly Asp Gly Asn Glu Asn Gly Glu Thr Val Arg Arg Asn Thr Glu Lys 
785                 790                 795                 800 


Phe Leu Lys Gln Val Phe Val Lys Gly Phe Asp Thr Tyr Leu Ser Arg 
                805                 810                 815     


Leu Pro Leu His Phe Leu Tyr Thr Pro Asn Ile Glu Lys Val Gln Glu 
            820                 825                 830         


Asp Lys Asp His Tyr Val Asp Leu Asp Ile Lys Val Lys His Gln Ile 
        835                 840                 845             


Asp Cys Thr Lys Gly Ala His Ile Ser Phe Phe Ala Phe Cys Lys Leu 
    850                 855                 860                 


Leu Asp Gly Asn His Leu Ser Asp Leu Arg Asn Glu Leu Leu Lys Tyr 
865                 870                 875                 880 


Ser Ala Thr Ser Lys Ala Met Gly Ser Ser Val Glu Tyr Asn Phe Ala 
                885                 890                 895     


Phe Asp Val Ile Glu Leu Cys Leu Leu Asp Asn Asp Lys Arg Met Glu 
            900                 905                 910         


Phe Asp Lys Glu Gly Gln Val Val Asn Ser Asp Thr Lys Ser Lys Leu 
        915                 920                 925             


Cys Lys Gly Thr Tyr Lys Lys Leu Leu Ala Pro Phe Val Lys Gly Asp 
    930                 935                 940                 


Glu Lys Thr Asn Arg Ile Trp Met Ala Phe Tyr Phe Gln Ser Asp Lys 
945                 950                 955                 960 


Glu Thr Pro Val Asp Tyr Gly Ser Leu Ala Leu Ile Arg Lys Phe Gly 
                965                 970                 975     


Thr Gln Lys Leu Leu Glu Ala Leu Ile Thr Asp Glu Tyr Lys Val Thr 
            980                 985                 990         


Glu Gln Asp Tyr Asp Glu Trp Val  Ala Leu Lys Arg Asp  Ile Asp Lys 
        995                 1000                 1005             


Lys Val  Gln Glu Arg Glu Gln  Leu His Ala Glu Trp  Val Glu Ala 
    1010                 1015                 1020             


Gly Gly  Lys Phe Val Ser Glu  Ser Asn Thr Asp Val  Tyr Phe Lys 
    1025                 1030                 1035             


Leu Cys  Lys Asp Ile Glu Arg  Tyr Asn Trp Leu Asp  Asn Lys Leu 
    1040                 1045                 1050             


His Leu  Val His Leu Lys Gln  Leu His Asn Phe Ile  Ile Gln Ile 
    1055                 1060                 1065             


Leu Ser  Arg Met Ala Arg Phe  Val Ala Met Arg Asp  Arg Asp Leu 
    1070                 1075                 1080             


Ala Phe  Val Lys Glu Leu Arg  Phe Pro Ala Tyr His  Lys Ser Phe 
    1085                 1090                 1095             


Phe Met  Gln Asp Asp Thr Leu  Lys Glu Cys Arg Asn  Tyr Ile Ala 
    1100                 1105                 1110             


His Phe  Asn Tyr Val Thr Thr  Thr Ala Ser Ser Ser  Leu Ile Asp 
    1115                 1120                 1125             


Ile Leu  Asn Ser Leu Arg Glu  Leu Met Ala Tyr Asp  Arg Lys Leu 
    1130                 1135                 1140             


Arg Asn  Ala Val Thr Lys Ser  Ile Ile His Val Phe  Lys Gln Asn 
    1145                 1150                 1155             


Gly Met  Asn Leu Gln Leu Gly  Trp Val Asp Asn Gly  Arg Lys Ser 
    1160                 1165                 1170             


Asp Ser  Ile His Arg Leu Met  Val Lys Ser Val Lys  Ser Glu Pro 
    1175                 1180                 1185             


Ile Lys  Leu Leu Lys Ala Glu  Leu Thr Ile Asp Gln  Val Pro Glu 
    1190                 1195                 1200             


Glu Tyr  Cys Arg Leu Cys Lys  Trp Leu Leu Glu Met  Lys Lys 
    1205                 1210                 1215         


<210>  188
<211>  1353
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  188

Met Lys Val Thr Lys Ala Glu Lys Leu Arg Val Ala Val Ser Arg Lys 
1               5                   10                  15      


Leu Asn Asn Glu Asp Lys Arg Ala Val Leu Tyr Lys Thr Pro Asn Pro 
            20                  25                  30          


Gly Gln Thr Cys Gly Thr Val Lys Lys Gln Leu Ala Asn Arg Val Glu 
        35                  40                  45              


Arg Ala Asn Lys Leu Tyr Gly Val Phe Phe Arg Ser Asp Val Pro Glu 
    50                  55                  60                  


Thr Leu Gln Tyr His Phe Glu Glu Leu Val Thr Tyr Ala Ala Gln Ser 
65                  70                  75                  80  


Thr Ser Pro Asn Glu Phe Arg Gln Lys Ala Ser Gln Tyr Arg Glu Cys 
                85                  90                  95      


Glu Lys Lys Asp Lys Phe Gly Lys Met Arg Lys Tyr Pro Ile Phe Arg 
            100                 105                 110         


Cys Ser Tyr Ala Pro Ser Gly Lys Asn Met Lys Lys Val Met Glu Leu 
        115                 120                 125             


Tyr Val Arg Glu Arg Met Lys Asp Glu Trp Gln Ser Gln Ala Tyr Arg 
    130                 135                 140                 


Thr Ala Ala Ile Glu Ile Leu Leu Cys Ile Cys Asn Lys Asp Phe Ser 
145                 150                 155                 160 


Lys Gln Leu Ser Arg Val Asp Ala Arg Ile Phe Ala Asp Phe Tyr Asn 
                165                 170                 175     


Ala Ser Lys Ala Cys Pro Gln Pro Tyr Ile Gly Lys Ser Thr Gly Val 
            180                 185                 190         


Leu Glu Ala Ala Phe Thr Ser Val Met Lys Gln Met Ser Leu His Ala 
        195                 200                 205             


Lys Ala Asn Ala Ser Asn Lys Ile Trp Trp Leu Gln Asn Gln Leu Arg 
    210                 215                 220                 


Thr Ile Glu Leu Asn Lys Lys Ile Val Lys Ile Ser Asp Phe Lys Tyr 
225                 230                 235                 240 


Glu Tyr Ala Thr Glu Asp Arg Met Arg Ala Ile Leu Val Arg Met Arg 
                245                 250                 255     


Lys Ser Leu Lys Arg Gly Thr Asn Gly Asp Ile Ala Val Ala Leu Leu 
            260                 265                 270         


Gln Gly Ile Ala Gln Met Asn Gly Lys Thr Leu Ser Gly Val Leu Glu 
        275                 280                 285             


Glu Leu Ser Ala Asn Ser Glu Thr Lys Glu Gln Leu Ile Lys Phe Leu 
    290                 295                 300                 


Lys Ala Val His Glu Asp Tyr His Lys Thr Pro Ile Leu Lys Ala Ile 
305                 310                 315                 320 


Arg Asn Gln Asp Val Lys Val Gln Val His Glu Val Asp Pro Val Ser 
                325                 330                 335     


Pro Glu Gly Arg Ala Leu Asp Leu Ala Ser Ile Asn Val Ser Lys Gly 
            340                 345                 350         


Asn Glu Arg Lys Lys Tyr Lys Val Ala Leu Thr Gln Thr Leu Gly Asn 
        355                 360                 365             


Tyr Ala Lys Ser Pro Lys Asp Ala Thr Gln Thr Leu Lys Ala Ile Lys 
    370                 375                 380                 


Gly Val Leu Leu Asp Tyr Phe Met Trp Leu Asp Ser Asp Val Lys Ala 
385                 390                 395                 400 


Glu Phe Leu Glu Asp Asn Asn Leu Trp Lys Ile Pro Asn Arg Thr Glu 
                405                 410                 415     


Glu Tyr Phe Asp Asn Asn Phe Val Pro Ile Asp Asp Lys Lys Asp Asp 
            420                 425                 430         


Lys Ile Glu Ala Ile Glu Asp Phe Ala Ser Ile Trp Arg Gln Glu Arg 
        435                 440                 445             


Val Lys Asn Ser Arg Ile Lys Ala Arg Met Asn Tyr Val Asn Cys Gly 
    450                 455                 460                 


Lys Tyr Gln Gln Leu Ile Lys Gln Glu Thr Asp Asp Phe Arg Ile Cys 
465                 470                 475                 480 


Trp Ile Ser Tyr Ala Lys Asp Phe Val Glu Lys Asn Tyr Val Ser Lys 
                485                 490                 495     


Asn Arg Gln Phe Thr Gln Gly Asp Cys Phe Ser Thr Lys Met Leu Leu 
            500                 505                 510         


Glu Cys Trp Lys Glu Ile Ile Arg Phe Ile Cys Gly Lys Tyr Ile Asp 
        515                 520                 525             


Ile Gly Lys Ala Val Tyr His Phe Ala Met Pro Glu Thr Met Asn Ala 
    530                 535                 540                 


Arg Asp Ser Leu Ala Tyr Gly Val Leu Gly Glu Lys Tyr Lys Glu Gly 
545                 550                 555                 560 


Ile Ser Ser Phe Asp Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln 
                565                 570                 575     


Arg Asp Ile Ala Lys Ala Ala Val Ala Ala Ile His Ala Phe Ser Gly 
            580                 585                 590         


Ser Val Ile Asp Asp Lys Lys Pro Val Glu Asp Ile Leu Phe Ile Lys 
        595                 600                 605             


Asp Glu Glu Leu Gln Glu His Ala Lys Ala Asp Asp Val Ile Val Lys 
    610                 615                 620                 


Gln Ile Leu Arg Phe Tyr Gly Gly Phe Ser Ser Val Glu Gly Arg Glu 
625                 630                 635                 640 


Lys Leu Glu Gly Met Ala Leu Ala Lys Glu Val Leu Ser Gln Leu Lys 
                645                 650                 655     


Ala Ile Arg Asn Glu Asn Phe His Phe Thr Gln Gly Lys Arg Lys Asn 
            660                 665                 670         


Val Glu Glu Asn Ile Pro Leu Thr Lys Ala Leu Trp Glu Asn Glu Glu 
        675                 680                 685             


Lys Val Tyr Arg Gln Thr Val Lys Glu Thr Tyr Tyr Ser Asn Asn Val 
    690                 695                 700                 


Ser Met Phe Tyr Ser Gln Glu Val Ile Gln Lys Leu Val Ala Glu Leu 
705                 710                 715                 720 


Tyr Gln Asn Asn Asn Val Ala Glu Ala Gln Ile Pro Ala Phe Arg Thr 
                725                 730                 735     


Ile Trp Lys Arg Lys Asp Leu Pro Glu Tyr Ile Gly Ser Leu Asn Ile 
            740                 745                 750         


Ser Trp Asp Lys Thr Glu Pro Lys Gln Val Ile Tyr Glu Gly Ala Leu 
        755                 760                 765             


Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Lys Ser Gly 
    770                 775                 780                 


Glu Ala Lys Lys Leu Phe Phe Asp Ala Val Met Asp Asn Ala Thr Glu 
785                 790                 795                 800 


Met Glu Lys Ser Ser Asn Ala Asp Ser Arg Asn Gln Glu Lys Lys Ala 
                805                 810                 815     


Leu Ala Asn Ala Gly Lys Asn Phe Arg Asp Tyr Val Asn Gly Leu Asn 
            820                 825                 830         


Ala Ser Thr Leu Gly Glu Val Cys Gln Phe Ile Gln Asn Glu Tyr Asn 
        835                 840                 845             


Gln Gln Asn Arg Gly Lys Gln Glu Gln Glu Ile Tyr Lys His Phe Lys 
    850                 855                 860                 


Met Leu Leu Pro Ile Cys Met Arg Lys Ala Phe Gln Arg Tyr Ile Asp 
865                 870                 875                 880 


Glu Lys His Ser Phe Ile Lys Lys Pro Gly Glu Leu Pro Gln Thr Thr 
                885                 890                 895     


Glu Asp Tyr Leu Glu Asn Val Lys Val Ala Cys Pro Glu Lys Lys Ile 
            900                 905                 910         


Lys Leu Gly Arg Trp Phe Thr Phe Ala His Phe Ile His Pro Arg Glu 
        915                 920                 925             


Leu Asn Phe Leu Ile Gly Asp Phe Lys Asn Tyr Ile Gln Tyr Arg Glu 
    930                 935                 940                 


Asp Val Leu Arg Arg Ser Glu His Ala Gly Gln Phe Ser Asp Thr Thr 
945                 950                 955                 960 


Glu Arg Asp Gly Glu Lys Ala Val Val Asp His Ala Val Gln Lys Ala 
                965                 970                 975     


Lys Asp Ile Leu Gly Val Leu Glu Phe Val Arg His Ile Ser Gly Arg 
            980                 985                 990         


Val Ser Asn Glu Phe Thr Asp Tyr  Tyr Ala Asp Arg Ala  Glu Tyr Asp 
        995                 1000                 1005             


Glu Tyr  Met Ala Lys Tyr Phe  Glu Pro Asp Val Gln  Ile Glu Gln 
    1010                 1015                 1020             


Tyr Asp  Leu Tyr Gly Asp Ala  Lys Asn Ala Lys Val  Ile Arg Asn 
    1025                 1030                 1035             


Ile Glu  Leu Ala Arg Met Tyr  Ala Gly Asp Ser Leu  Met Ser Ala 
    1040                 1045                 1050             


Ser Tyr  Arg Lys Ile Thr Lys  Lys Glu Ile Glu Thr  Tyr Tyr Ala 
    1055                 1060                 1065             


Lys Lys  Asp Glu Ile Ala Gln  Leu Gln Ser Gln Gly  Ile Cys Asn 
    1070                 1075                 1080             


Ser Lys  Lys Glu Gln Glu Asp  Ile Val Ala Phe Gln  Lys Leu Lys 
    1085                 1090                 1095             


Asn Arg  Ile Thr Leu Asn Glu  Val Thr Asp Leu Trp  Ser Leu Val 
    1100                 1105                 1110             


Asn Glu  Leu Leu Gly Asn Leu  Val Ser Leu Ala Tyr  Leu Arg Glu 
    1115                 1120                 1125             


Arg Asp  Glu Met Tyr Leu Phe  Leu Gly Phe Tyr Tyr  Met Ala Leu 
    1130                 1135                 1140             


Arg His  Pro Glu Gly Trp Thr  Asn Glu Ile Met Asn  Ser Val Ser 
    1145                 1150                 1155             


Asn Glu  Lys Tyr Ala Val Lys  Glu Gly Leu Val Leu  Tyr Gln Thr 
    1160                 1165                 1170             


Val Ala  Val Phe Asp Phe Gly  Thr Lys Leu Leu Phe  Gln Asn Asp 
    1175                 1180                 1185             


Asn Gln  Lys Trp Glu Glu Thr  Thr Gly Tyr Lys Trp  Gln His Phe 
    1190                 1195                 1200             


Ile Asp  Asn His Lys Glu Ser  Tyr Ala Cys Ile Leu  Pro Leu Phe 
    1205                 1210                 1215             


Glu Ile  Ala Lys Cys Glu Thr  Glu Ala Arg Ala Val  Arg Asn Tyr 
    1220                 1225                 1230             


Val Asp  His Phe Lys Tyr Tyr  Ser Asn Glu Asp Arg  Ser Ile Leu 
    1235                 1240                 1245             


Glu Leu  Tyr Gly Lys Phe Tyr  Thr His Leu Phe Gly  Tyr Ser Thr 
    1250                 1255                 1260             


Arg Leu  Arg Lys Ser Val Leu  Gln Ile Leu Ala Gln  Thr Leu Glu 
    1265                 1270                 1275             


Lys His  Gly Ile Ser Ala Gly  Ile Gln Phe Asp Gly  Thr Thr Val 
    1280                 1285                 1290             


Lys Ala  Thr Arg Cys Asp Met  Lys Ser Val Glu Phe  Thr Tyr Lys 
    1295                 1300                 1305             


Tyr Glu  Glu Lys Leu Asn Glu  Gln Lys Thr Val Leu  Arg Thr Ile 
    1310                 1315                 1320             


Ser Leu  Pro Ala Lys Ser Glu  Gly Phe Ile Thr Ala  Val Cys Glu 
    1325                 1330                 1335             


Met Leu  Lys Gln Lys Lys Gly  Asp His Thr Glu Asn  Thr Leu Cys 
    1340                 1345                 1350             


<210>  189
<211>  1330
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  189

Met Lys Arg Glu Lys Asn Ile Thr Ile Met Lys Ile Ser Lys Val Asn 
1               5                   10                  15      


His Arg Arg Thr Ala Val Ala Leu Asn Gly Asp Lys Ser Glu Leu Gly 
            20                  25                  30          


Gly Ile Leu Tyr Glu Ala Pro Val Gln Lys Asp Arg Asn Gly Asn Tyr 
        35                  40                  45              


Asn Asp Val Ile Ala Glu Thr Gly Lys Val Val Asn Glu Ala Leu Asp 
    50                  55                  60                  


Lys Lys Ser Arg Leu Tyr Thr Pro Phe Asn Asn Gln Lys Val Ile Ile 
65                  70                  75                  80  


Asp Lys Asn Leu Gln Arg Tyr Ala Asn Asn Leu Lys Arg Cys Tyr Ile 
                85                  90                  95      


Asn Phe Val Lys Gln Tyr Val Asn Asn Lys Ser Phe Asn Tyr Lys Ala 
            100                 105                 110         


Met Gln Phe Ile Pro Asp Ile Gln Asn Pro Lys Thr Asn Asp Ala Val 
        115                 120                 125             


Asn Tyr Arg Thr Asp Arg Asp Asn Val Tyr Asn Lys Asn Lys Tyr Tyr 
    130                 135                 140                 


Asp Lys Gln Thr Lys Ser Lys Ser Lys Lys Phe Ile Tyr Glu Lys Ile 
145                 150                 155                 160 


Val Ile Pro Gln Asn Glu Gln Asn Ile Val Ile Ser Ala Leu Val Asn 
                165                 170                 175     


Cys Ser Leu Arg Lys Ser Leu Arg Lys Asp Val Ser Tyr Lys Thr Lys 
            180                 185                 190         


Thr Gly Glu Ile Lys Thr Tyr Asn Leu Pro Glu Leu Val Lys Lys Ser 
        195                 200                 205             


Met Arg Phe Tyr Cys Leu Glu Gly Gln Arg Glu Pro Asp Glu Lys Glu 
    210                 215                 220                 


Lys Tyr Glu Met Tyr Ile Leu Phe Ser Tyr Met Lys Glu Asp Lys Arg 
225                 230                 235                 240 


Thr Lys Asn Thr Asp Leu Leu Val Lys Ser Ile Ser Asn Gln Asn Thr 
                245                 250                 255     


Lys Val Lys Val Glu Asp Ile Asp Gly Asn Lys Leu Leu Lys Leu Ser 
            260                 265                 270         


Ile Ala Asp Thr Lys Lys Lys Pro Leu Trp Glu Tyr Leu Ile Lys Tyr 
        275                 280                 285             


Ala Asp Ser Ser Arg Gln Arg Glu Leu Met Tyr Asp Ile Arg Lys Lys 
    290                 295                 300                 


Ile Val Leu Tyr Val Ala Gly Ile Glu Glu Tyr Glu Asn Ile Lys Glu 
305                 310                 315                 320 


Asp Ser Gly Leu Ser Lys Val Ser Trp Ser Lys Tyr Asn Ile Ser Asp 
                325                 330                 335     


Asn Lys Met Phe Phe Asp Ile Asn Ser Cys Thr Asp Lys Arg Lys Gln 
            340                 345                 350         


Asn Leu Glu Ile Lys Ile Arg Glu Ala Asn Ile Glu His Tyr Arg Asn 
        355                 360                 365             


Ala Ser Ser Lys Leu Cys Asp Asp Glu Ser Ile Phe Trp Phe Gln His 
    370                 375                 380                 


Phe Glu Gly Val Ile Glu Thr Leu Phe Ser Lys Lys Ser Lys Ile Ser 
385                 390                 395                 400 


Glu Glu Arg Leu Gly Cys Ala Tyr Ile Cys Asp Tyr Leu Trp Lys Asp 
                405                 410                 415     


Phe Leu Ser Tyr Leu Ala Ala Lys Tyr Ile Asp Leu Gly Lys Gly Val 
            420                 425                 430         


Tyr His Phe Thr Met Lys Asp Lys Leu Asp Met Leu Asn Lys Asn Glu 
        435                 440                 445             


Ala Val Thr Asp Leu Arg Phe Gly Ile Val Ser Glu Lys Tyr Glu Lys 
    450                 455                 460                 


Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Glu Leu 
465                 470                 475                 480 


Asp Arg Asn Ile Ala Ala Tyr Val Thr Phe Ala Ala Asp Ile Phe Ala 
                485                 490                 495     


Lys Ser Val Ile Lys Ser Asp Tyr Arg Thr Lys Lys Asp Asn Asn Ser 
            500                 505                 510         


Asp Val Leu Gln Tyr Ser Asp Lys Glu Phe Arg Asn Ser Glu Val Ile 
        515                 520                 525             


Arg Asp Asn Ala Glu Lys Asn Ile Leu Gln Tyr Trp Gly Gly Tyr Ser 
    530                 535                 540                 


Arg Trp Gly Thr Glu Asn Ser Lys Leu Pro Glu Asn Asn Lys Val Ser 
545                 550                 555                 560 


Asp Phe Gly Lys Leu Asp Val Ser Asp Leu Cys Ile Asp Ile Lys Lys 
                565                 570                 575     


His Leu Ala Gly Ile Arg Asn Ser Ser Val His Tyr Thr Thr Lys Ile 
            580                 585                 590         


Lys Asn Glu Ser Ala Ala Asp Gly Ser Asn Val Lys Ile Leu Phe Glu 
        595                 600                 605             


Lys Asp Leu Ala Asp Ile Asn Ile Ile Tyr Ala Asp Lys Tyr Tyr Ser 
    610                 615                 620                 


Asn Asn Val Trp Met Phe Tyr Ser Leu Glu Asp Ile Asn Lys Leu Ile 
625                 630                 635                 640 


Ala Phe Leu Tyr Lys Glu Lys Arg Val Ile Arg Gln Val Gln Ile Pro 
                645                 650                 655     


Ser Phe Ser Arg Ile Leu Lys Arg Lys Ala Met Gln Asp Val Ile Asn 
            660                 665                 670         


Glu Ile Phe Lys Asp Asp Phe Asp Glu Asn Ile Val Asn Pro Glu Leu 
        675                 680                 685             


Lys Glu Lys Tyr Arg Asn Ser Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
    690                 695                 700                 


Tyr Asn Ala Phe Ile Ile Gln Pro Glu Leu Lys Glu Lys Phe Lys Asp 
705                 710                 715                 720 


Lys Ile Lys Thr Met Lys Ser Glu Leu Tyr Asn Lys Leu Lys Thr Ile 
                725                 730                 735     


Asp Lys Lys Glu Tyr Lys Ala Leu Tyr Cys Met Leu Ser Asn Glu Glu 
            740                 745                 750         


Ser Ala Leu Lys Asn Phe Ala Asp Arg Ile Tyr Ser Val Asp Gly Asp 
        755                 760                 765             


Asn Val Ser Phe Ala Asp Ile Cys Lys Ile Leu Met Thr Asp Tyr Asn 
    770                 775                 780                 


Met Gln Asn Gln Glu Lys Lys Asn Ile Glu Ser Met Glu Gln Lys Lys 
785                 790                 795                 800 


Lys Asn Lys Gly Lys Asp Glu Asn Tyr Lys His Phe Pro Leu Leu Leu 
                805                 810                 815     


His Lys Val Leu Lys Glu Leu Phe Ile Glu Tyr Leu Lys Gln Thr His 
            820                 825                 830         


Glu Leu Glu Phe Leu Arg Asn Asn Ile Cys Ile Lys Ser Asp Val Thr 
        835                 840                 845             


Met Glu Ser Phe Glu Ser Gln Ile Lys Gly Val Glu Ile Tyr Lys Asp 
    850                 855                 860                 


Leu Lys Glu Lys Ile Asp Lys Asn Asn Ser Leu Leu Asp Trp Tyr Val 
865                 870                 875                 880 


Ile Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asn 
                885                 890                 895     


Ile Lys Asn Tyr Ile Gln Phe Ala Thr Asn Ile Asp Lys Arg Ala Glu 
            900                 905                 910         


Ser Val Lys Asn Leu Thr Glu Ser Gly Met Val Lys Arg Ile Gln Tyr 
        915                 920                 925             


Tyr Asp Asp Ile Val Arg Thr Leu Glu Phe Ser Ala Gln Tyr Ile Gly 
    930                 935                 940                 


Lys Ile Ser Asn Asn Ile Asn Asp Tyr Phe Asn Ser Glu Asp Glu Tyr 
945                 950                 955                 960 


Val Ser Phe Leu Ser Lys Tyr Val Gly Phe Ile Asn Asp Lys Ser Glu 
                965                 970                 975     


Asp Val Leu Thr Glu Leu Lys Asp Phe Cys Arg Glu Lys Ile Asn Asn 
            980                 985                 990         


Gly Ser Gln Ile Ile Gly Ile Tyr  Tyr Gly Gly Asp Asn  Val Ile Ile 
        995                 1000                 1005             


Asn Arg  Asn Val Ile Tyr Ala  Gln Met Tyr Ser Asn  Ala Glu Val 
    1010                 1015                 1020             


Phe Ser  Asn Ile Tyr Lys Lys  Val Thr Lys Asn Asp  Ile Ile Asn 
    1025                 1030                 1035             


Tyr Tyr  Glu Lys Gln Asn Asp  Leu Lys Asp Val Phe  Lys Ser Gly 
    1040                 1045                 1050             


Val Cys  Gln Asn Glu Asp Glu  Gln Arg Ser Leu Cys  Glu Phe Gln 
    1055                 1060                 1065             


Gln Leu  Lys Asn Arg Ile Glu  Leu Thr Glu Leu Ser  Thr Tyr Ala 
    1070                 1075                 1080             


Asp Met  Val Asn Asp Phe Met  Ala Gln Phe Val Glu  Trp Ala Tyr 
    1085                 1090                 1095             


Leu Arg  Glu Arg Asp Leu Met  Tyr Phe Gln Leu Gly  Ile His Tyr 
    1100                 1105                 1110             


Ile Arg  Leu Phe Tyr Ser Asp  Asn Val Leu Asp Glu  Lys Tyr His 
    1115                 1120                 1125             


Lys Leu  Ser Asp Asn Val Ile  Asp Ile Glu Glu Gly  Ala Leu Leu 
    1130                 1135                 1140             


Tyr Gln  Ile Val Ala Met Tyr  Asp Tyr Glu Leu Arg  Ile Phe Glu 
    1145                 1150                 1155             


Thr Asp  Asn Phe Gly Asn Ala  Lys Arg Ile Gly Gln  Gly Gly Pro 
    1160                 1165                 1170             


Gly Lys  Ser Ile Pro Val Phe  Leu Lys Lys Tyr Cys  Asn Gly Thr 
    1175                 1180                 1185             


Asp Val  Tyr Glu Cys Gly Leu  Glu Leu Phe Glu Asp  Ile Asn Gln 
    1190                 1195                 1200             


His Glu  His Ile Ile Arg Phe  Arg Asn Asp Ile Ala  His Met Arg 
    1205                 1210                 1215             


Tyr Met  Ser Asn Gln Ala Met  Asn Ile Met Ser Ile  Val Ser Asn 
    1220                 1225                 1230             


Ile Tyr  Lys Ser Phe Phe Val  Tyr Asp Thr Lys Leu  Lys Lys Ser 
    1235                 1240                 1245             


Ile Ser  Leu Val Phe Lys Asn  Ile Leu Met Arg Tyr  Gly Val Ile 
    1250                 1255                 1260             


Ala Asp  Leu Val Phe Ser Tyr  Asn Asn Lys Asn Gln  Ser Ile Lys 
    1265                 1270                 1275             


Asp Asp  Met Asp Ile Asn Ile  Ile Asn Ile Lys Asn  Leu Lys Ser 
    1280                 1285                 1290             


Asp Lys  Tyr Val Tyr Lys Ile  Val Asn Glu Asp Ile  Val Lys Gln 
    1295                 1300                 1305             


Val Glu  Ile Glu Ile Arg Asn  Gln Val Phe Leu Glu  Gln Leu His 
    1310                 1315                 1320             


Lys Leu  Leu Tyr Phe Ser Arg  
    1325                 1330 


<210>  190
<211>  1351
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  190

Met Gln Ile Leu Lys Pro Ile Gly Arg Ser Ser Thr Arg Tyr Ala Ile 
1               5                   10                  15      


Glu Lys Asn Thr Phe Leu Leu Arg Arg Phe Leu Ala Asp Arg Tyr Leu 
            20                  25                  30          


Asp Ala Phe Ser Asn Glu Leu Ala Val Pro Ile Glu Asp Ile Ser Val 
        35                  40                  45              


Leu Arg Met Ile Pro Ile Asp Glu Gly Arg Glu Leu Val Arg Gln Ala 
    50                  55                  60                  


Ala Ser Leu Phe Asn Lys Thr Val Lys Ser Ser Arg Leu Leu Arg Asn 
65                  70                  75                  80  


Met Asp Met Gln Thr Tyr Val Asp Arg Val Phe Leu Ser Gln Glu Leu 
                85                  90                  95      


Ile Lys Tyr Ile Leu Asp Ala Val Asn Ile Arg Asp Gly Ala Glu Phe 
            100                 105                 110         


Ser Ser Leu Lys Glu Leu Trp Val Gly Leu Val His Pro Tyr Ala Ser 
        115                 120                 125             


His Glu Ile Asp Asn Arg Ser Pro Ser Glu Asp Lys Asn Ala Ala Ile 
    130                 135                 140                 


Ile Lys Lys Phe Gly Leu Lys Asp Ala Thr Arg Val Ser Phe Asn Gly 
145                 150                 155                 160 


Arg Trp His Asp Ala Phe Trp Val Leu Gly Lys Asn Gly Lys Pro Asp 
                165                 170                 175     


Tyr Ala Ala Ile Ala Leu Asn Met Met Thr His Leu Val Phe Asp Glu 
            180                 185                 190         


Met Lys Ile Asn Gly Asp Leu Arg Gln Cys Arg Asn Lys Tyr Gly Glu 
        195                 200                 205             


Phe Asn Gly Ala Ile Val Arg Arg Ala Leu Ser Ile Phe Thr Ser Thr 
    210                 215                 220                 


His Asp Pro Arg Phe Ser Ser Asn Arg Thr Ile Ser Asp Phe Ala Thr 
225                 230                 235                 240 


Glu Tyr Tyr Phe Tyr Lys Asp Val Ala Glu Glu Ile Phe Gly Leu Ala 
                245                 250                 255     


His Ala Ser Glu Ser Lys Asp Val Arg Leu Thr His Lys Glu Ala Gly 
            260                 265                 270         


Arg Val Leu Tyr Glu His Phe Gly Gly Asn Pro Asn Ala Gly Ser Tyr 
        275                 280                 285             


Lys Glu Phe Asp Arg Glu Ile Gln Lys Gln Ile Trp Glu Leu His Asn 
    290                 295                 300                 


Lys Val Arg Ser Phe Tyr Ala Asp Ala Leu Ser Ser Val Arg Phe Val 
305                 310                 315                 320 


Arg Ile Phe Asp Lys Asp Gly Ala Arg Arg Asn Glu Ile Ile Ser Val 
                325                 330                 335     


Ile Pro Pro Asn Lys Leu Ser Leu Leu Ala Arg Leu Lys Val Arg Ser 
            340                 345                 350         


Glu Lys Arg Asp Leu Val Arg Met Val Arg Leu Gly Lys Ala Val Val 
        355                 360                 365             


His Ala Leu Asp Lys Ser Ser Ser Ala Thr Asp Glu Glu Ala Gln Gly 
    370                 375                 380                 


Ala Phe Asn Val Asn Leu Asp Phe Leu Leu Thr Ser Glu Gly Gln Ala 
385                 390                 395                 400 


Glu Ile Lys Arg Val Glu Ser Phe Ala Arg Ala Trp Arg Glu Ser Val 
                405                 410                 415     


Gly Leu Ser Cys Arg Thr Ile Gly Val Trp Ser Lys Leu Ala Ser Ala 
            420                 425                 430         


Pro Pro Lys Lys Asp Gly Thr Asp Trp Asp Val Thr Glu Ala Asp Tyr 
        435                 440                 445             


Ala Lys Lys Arg Val Pro Leu Leu Ser Pro Glu Thr Asp Ile Arg Pro 
    450                 455                 460                 


Ala Ala Arg Leu Ile Phe Gly Asp Lys Gln Val Gly Arg Gly Lys Thr 
465                 470                 475                 480 


Ser Arg Leu Glu Ala Ile Leu Ala Thr Glu Ser Asn Pro Thr Glu Ile 
                485                 490                 495     


Leu Trp Gly Phe Val Arg Leu Asn Ser Glu Met Arg Asn Ala Ser Ala 
            500                 505                 510         


His Phe Asn Thr Arg Lys Arg Phe Val Glu Leu Ile Gln Asp Ser Ile 
        515                 520                 525             


Ile Lys Pro Leu Lys Ala Pro Thr Val Asn Tyr Glu Asn Arg Gly Gly 
    530                 535                 540                 


Asn Glu Val Ala Leu Glu Ala Leu Glu Ala Phe Gly Arg Leu Leu Gln 
545                 550                 555                 560 


Phe Asp Glu Ser Leu Val Phe Asp Leu Leu Glu Glu Glu Ile Lys Ser 
                565                 570                 575     


Leu Arg Leu Asp Arg Phe Ala Ala Asp Ala Asp Leu Lys Ala Leu Val 
            580                 585                 590         


Arg Glu Ala Ser Pro Asn Thr Ser Gly Ser Gln Ile Ala Thr Pro Lys 
        595                 600                 605             


Phe Met Ser Leu Met Glu Arg Ala Val Gly Leu Ala Thr Ser Arg Ser 
    610                 615                 620                 


Glu Phe Val Pro Asp Glu Leu Gln Arg Phe Ala Arg Leu Asn Leu Ala 
625                 630                 635                 640 


Gly Leu Ser Ser Arg Ser Asp Glu Asp Asp Val Ser Arg Ile Gly Ala 
                645                 650                 655     


Leu Arg Leu Val Tyr Gly Arg Gly Phe Glu Arg Trp Leu Thr Glu His 
            660                 665                 670         


Leu Ser Asp Ser Ser Gln Ile Arg Gln Leu Leu Arg Arg Ile Gly Glu 
        675                 680                 685             


Leu His Thr Lys Arg Arg Leu Glu Tyr Asp Ser Ala His Asn Arg Pro 
    690                 695                 700                 


Thr Gln Pro Gly Ile Asp Leu Leu Glu Arg Ile Asp Ile Asp Ser Ile 
705                 710                 715                 720 


Ser Ser Leu Glu Asp Leu Ala Arg Arg Leu Thr Ile Glu Ala Met Thr 
                725                 730                 735     


Asp Ser Ser Leu Ala Thr Arg Ala Arg Arg Ala Ser Arg Asn Arg Tyr 
            740                 745                 750         


Glu Gln Asn Val Leu Thr Asp Glu Arg Arg Gln Arg Ser Gly Gln Val 
        755                 760                 765             


Glu Leu Val Arg Gln Glu Ile Tyr Gly Cys Leu Phe Ala Arg Tyr Leu 
    770                 775                 780                 


Asn Glu Ser Gly Leu Asp Trp Ile Phe Ala Asp Phe Pro Glu Pro Lys 
785                 790                 795                 800 


Asp Val Ala Val Pro Phe Glu Ile Gly Ala Thr Thr Ser Ser His His 
                805                 810                 815     


Pro Ser Trp His Ala Ser Phe Tyr Gly Trp Leu Tyr Leu Leu Pro Pro 
            820                 825                 830         


Asp Asp Val Ala Leu Leu Arg His Gln Phe Lys Lys Thr Ala Ala Leu 
        835                 840                 845             


Glu Glu Arg Ala Glu Asp Gly Leu Ser Pro Asp Asp Met Thr Val Leu 
    850                 855                 860                 


Tyr Asp Ile Asp Gly Leu Met Ala Leu Tyr Val Ser Val Gln Ser Ala 
865                 870                 875                 880 


Gly Phe Gly Gly Arg Glu His Ala Ile Asp Val Lys Pro Glu Arg Gly 
                885                 890                 895     


Ala Gly Thr Asp Arg Ser Val Tyr Tyr Glu Asp Thr Ser Gln Phe Ala 
            900                 905                 910         


Arg Val Phe Ser Glu Asp Lys Glu Thr His Arg Asp Ser Val Pro Gly 
        915                 920                 925             


Thr Arg Arg Gly Leu Arg Gln Leu Arg Phe Glu Asn Ile Pro Ser Leu 
    930                 935                 940                 


Leu Ser Ile Phe Glu Lys His Arg Val Thr Val Pro Glu Val Glu Ser 
945                 950                 955                 960 


Phe Met Lys Lys Ala Gly Pro Asp Asn Ala Ile Arg Val Gly Leu Leu 
                965                 970                 975     


Glu Glu Lys Thr Lys Leu Arg Asn Lys Leu Ala Asp Met Ala Lys Ser 
            980                 985                 990         


Arg Asp Ser Arg Pro Phe Met Ala  Pro Asp Val Glu Arg  Tyr Arg Ser 
        995                 1000                 1005             


Leu Ala  Gly Glu Leu Ala Arg  Tyr Asp Phe Glu Ile  Asn Ala Ala 
    1010                 1015                 1020             


Arg Leu  Thr Glu Phe Ser Arg  Leu Tyr Arg Leu Ala  Met Arg Ile 
    1025                 1030                 1035             


Ile Gly  Arg Leu Asn Asp Phe  Thr Leu Met Trp Glu  Arg Asp Arg 
    1040                 1045                 1050             


Leu Tyr  Met Leu Met Gly Met  Leu Tyr Glu Lys Leu  Gly Ala Glu 
    1055                 1060                 1065             


Gly Phe  Arg Val Glu Val Lys  Ala Trp Asn Asn Gly  Thr Glu Gln 
    1070                 1075                 1080             


Arg Arg  Trp Ile Ala Ile Ala  Val Gly Asp Gly Ala  Ser Ser Gly 
    1085                 1090                 1095             


Ala Ile  Asp Glu Lys Pro Pro  Ser Arg Ala Gly Asp  Val Ser Thr 
    1100                 1105                 1110             


Trp Met  Leu Arg Lys Tyr Ser  Cys Leu Pro Ile Trp  Asp Ser Arg 
    1115                 1120                 1125             


Phe Gly  Ile Val Ala Lys Gly  Thr Glu Glu Glu Thr  Lys Leu Leu 
    1130                 1135                 1140             


Ser Pro  Glu Asp Arg Ile Val  Phe Val Arg His Phe  Val Gly Ala 
    1145                 1150                 1155             


Glu Ala  Glu Asn Pro Arg Asp  Ile Glu Ala Arg Arg  Asp Lys Pro 
    1160                 1165                 1170             


Pro Ala  Pro Pro Arg Arg Gly  Ala Asp Ala Arg Ser  Trp Arg Asn 
    1175                 1180                 1185             


Gly Lys  Ala Lys Ile Arg Asn  Asp Phe Ala His Tyr  Asn Met Leu 
    1190                 1195                 1200             


Gly Ser  Ser Val Lys Ile Leu  Asn Leu Thr Tyr Arg  Val Asn Ala 
    1205                 1210                 1215             


Val Arg  Ser Leu Phe Gly Tyr  Asp Arg Lys Met Lys  Asn Val Val 
    1220                 1225                 1230             


Ser Lys  Ala Ile Ser Asp Ile  Leu Leu Asp Glu Gly  Leu Ala Ile 
    1235                 1240                 1245             


Arg Trp  Lys Met Arg Glu Asp  Arg Leu Arg Gly Ala  Leu Val Leu 
    1250                 1255                 1260             


Pro Leu  Val Arg Lys Glu Leu  Ala Phe Leu Gly Leu  Val Asp Gly 
    1265                 1270                 1275             


Lys Asp  Leu Ser Ile Asp Leu  Pro Gln Val Ser Val  Arg Phe Thr 
    1280                 1285                 1290             


Ser Met  Val Gln Ala Leu Phe  Gly Phe Asp Ser Gly  Gly His Arg 
    1295                 1300                 1305             


Glu Leu  Val Glu Thr Glu Gly  Lys Leu Lys Ala Arg  Gly Arg Leu 
    1310                 1315                 1320             


Thr Tyr  Pro Arg Glu Phe Leu  Ala Arg His Gly Asp  Arg Leu Pro 
    1325                 1330                 1335             


Lys Glu  Val Leu Ser Glu Tyr  Pro Ser Leu Pro Gln  Lys 
    1340                 1345                 1350     


<210>  191
<211>  1330
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  191

Met Lys Arg Glu Lys Asn Ile Thr Ile Met Lys Ile Ser Lys Val Asn 
1               5                   10                  15      


His Arg Arg Thr Ala Val Ala Leu Asn Gly Asp Lys Ser Glu Leu Gly 
            20                  25                  30          


Gly Ile Leu Tyr Glu Ala Pro Val Gln Lys Asp Lys Asn Gly Asn Tyr 
        35                  40                  45              


Asn Asp Val Ile Ala Glu Thr Gly Lys Val Val Asn Glu Ala Leu Asp 
    50                  55                  60                  


Lys Lys Ser Arg Leu Tyr Thr Pro Phe Asn Asn Gln Lys Val Ile Ile 
65                  70                  75                  80  


Asp Lys Asn Leu Gln Arg Tyr Ala Asn Asn Leu Lys Arg Cys Tyr Ile 
                85                  90                  95      


Asn Phe Val Lys Gln Tyr Val Asn Asn Lys Ser Phe Asn Tyr Lys Ala 
            100                 105                 110         


Met Gln Phe Ile Pro Asp Ile Gln Asn Leu Lys Thr Asn Asp Ala Val 
        115                 120                 125             


Asn Tyr Arg Thr Asp Arg Asp Asn Val Tyr Asn Lys Asn Lys Tyr Tyr 
    130                 135                 140                 


Asp Lys Gln Thr Lys Ser Lys Ser Lys Lys Phe Ile Tyr Glu Lys Ile 
145                 150                 155                 160 


Val Ile Pro Gln Asn Glu Gln Asn Ile Val Ile Ser Ala Leu Val Asn 
                165                 170                 175     


Cys Ser Leu Arg Lys Ser Leu Arg Lys Asp Val Ser Tyr Lys Thr Lys 
            180                 185                 190         


Ser Gly Glu Ile Lys Thr Tyr Asn Leu Pro Glu Leu Val Lys Lys Ser 
        195                 200                 205             


Met Arg Phe Tyr Cys Leu Glu Gly Gln Arg Glu Pro Asp Glu Lys Glu 
    210                 215                 220                 


Lys Tyr Glu Met Tyr Ile Leu Phe Ser Tyr Met Lys Glu Asp Lys Arg 
225                 230                 235                 240 


Thr Lys Asn Thr Asp Leu Leu Val Lys Ser Ile Ser Asn Gln Asn Thr 
                245                 250                 255     


Lys Val Lys Val Glu Asp Ile Asp Gly Asn Lys Leu Leu Lys Leu Ser 
            260                 265                 270         


Ile Ala Asp Thr Lys Lys Lys Pro Leu Trp Glu Tyr Leu Ile Lys Tyr 
        275                 280                 285             


Ala Asp Ser Ser Arg Gln Arg Glu Leu Met Tyr Asp Ile Arg Lys Lys 
    290                 295                 300                 


Ile Ile Leu Tyr Val Ala Gly Ile Glu Glu Tyr Glu Asn Ile Lys Glu 
305                 310                 315                 320 


Asp Ser Gly Leu Ser Lys Val Ser Trp Ser Lys Tyr Asn Ile Ser Asp 
                325                 330                 335     


Asn Lys Met Phe Leu Asp Ile Asn Ser Cys Thr Asp Lys Arg Lys Gln 
            340                 345                 350         


Asn Leu Glu Ile Lys Ile Arg Glu Ala Asn Ile Glu His Tyr Arg Asn 
        355                 360                 365             


Ala Ser Ser Lys Leu Cys Asp Asp Glu Ser Ile Phe Trp Phe Gln His 
    370                 375                 380                 


Phe Glu Gly Val Ile Glu Thr Leu Phe Ser Lys Lys Ser Lys Ile Ser 
385                 390                 395                 400 


Glu Glu Arg Leu Gly Cys Ala Tyr Ile Cys Asp Tyr Leu Trp Lys Asp 
                405                 410                 415     


Phe Leu Ser Tyr Leu Ala Ala Lys Tyr Ile Asp Leu Gly Lys Gly Val 
            420                 425                 430         


Tyr His Phe Thr Met Lys Asp Lys Leu Asp Met Leu Asn Lys Asn Glu 
        435                 440                 445             


Ala Val Thr Asp Leu Arg Phe Gly Ile Val Ser Glu Lys Tyr Glu Lys 
    450                 455                 460                 


Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Glu Leu 
465                 470                 475                 480 


Asp Arg Asn Ile Ala Ala Tyr Val Thr Phe Ala Ala Asp Ile Phe Ala 
                485                 490                 495     


Lys Ser Val Ile Lys Ser Asp Tyr Arg Thr Lys Lys Asp Asn Asn Ser 
            500                 505                 510         


Asp Val Leu Gln Tyr Ser Asp Lys Glu Phe Arg Asn Ser Glu Val Ile 
        515                 520                 525             


Arg Asp Asn Ala Glu Lys Asn Ile Leu Gln Tyr Trp Gly Gly Tyr Ser 
    530                 535                 540                 


Arg Trp Gly Thr Glu Asn Ser Lys Leu Pro Glu Asn Asn Lys Val Ser 
545                 550                 555                 560 


Asp Phe Gly Lys Leu Asp Val Ser Asp Leu Cys Ile Asp Ile Lys Lys 
                565                 570                 575     


His Leu Ala Gly Ile Arg Asn Ser Ser Val His Tyr Thr Thr Lys Ile 
            580                 585                 590         


Lys Asn Glu Ser Ala Ala Asp Gly Ser Asn Val Lys Ile Leu Phe Glu 
        595                 600                 605             


Lys Asp Leu Ala Asp Ile Asn Ile Ile Tyr Ala Asp Lys Tyr Tyr Ser 
    610                 615                 620                 


Asn Asn Val Trp Met Phe Tyr Ser Leu Glu Asp Ile Asn Lys Leu Ile 
625                 630                 635                 640 


Ala Phe Leu Tyr Lys Glu Lys Arg Val Ile Arg Gln Val Gln Ile Pro 
                645                 650                 655     


Ser Phe Ser Arg Ile Leu Lys Arg Lys Ala Met Gln Asp Val Ile Asn 
            660                 665                 670         


Glu Ile Phe Lys Asp Asp Phe Asp Glu Asn Ile Val Asn Pro Glu Leu 
        675                 680                 685             


Lys Glu Lys Tyr Arg Asn Ser Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
    690                 695                 700                 


Tyr Asn Ala Phe Ile Ile Gln Pro Glu Leu Lys Glu Lys Phe Lys Asp 
705                 710                 715                 720 


Lys Ile Lys Thr Met Lys Ser Glu Leu Tyr Asn Lys Leu Lys Thr Ile 
                725                 730                 735     


Asp Lys Lys Glu Tyr Lys Ala Leu Tyr Cys Met Leu Ser Asn Glu Glu 
            740                 745                 750         


Ser Ala Leu Lys Asn Phe Ala Asp Arg Ile Tyr Ser Val Asp Gly Asp 
        755                 760                 765             


Asn Val Ser Phe Ala Asp Ile Cys Lys Ile Leu Met Thr Asp Tyr Asn 
    770                 775                 780                 


Met Gln Asn Gln Glu Lys Lys Asn Ile Glu Ser Met Glu Gln Lys Lys 
785                 790                 795                 800 


Lys Asn Lys Gly Lys Asp Glu Asn Tyr Lys His Phe Pro Leu Leu Leu 
                805                 810                 815     


His Lys Val Leu Lys Glu Leu Phe Ile Glu Tyr Leu Lys Gln Thr His 
            820                 825                 830         


Glu Leu Glu Phe Leu Arg Asn Asn Ile Cys Ile Lys Ser Asp Val Thr 
        835                 840                 845             


Met Glu Ser Phe Glu Ser Gln Ile Lys Gly Val Glu Ile Tyr Lys Asp 
    850                 855                 860                 


Leu Lys Glu Lys Ile Asp Lys Asn Asn Ser Leu Leu Asp Trp Tyr Val 
865                 870                 875                 880 


Ile Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asn 
                885                 890                 895     


Ile Lys Asn Tyr Ile Gln Phe Ala Thr Asn Ile Asp Lys Arg Ala Glu 
            900                 905                 910         


Ser Val Lys Asn Leu Thr Glu Ser Gly Met Val Lys Arg Ile Gln Tyr 
        915                 920                 925             


Tyr Asp Asp Ile Val Arg Thr Leu Glu Phe Ser Ala Gln Tyr Ile Gly 
    930                 935                 940                 


Lys Ile Ser Asn Asn Ile Asn Asp Tyr Phe Asn Ser Glu Asp Glu Tyr 
945                 950                 955                 960 


Val Ser Phe Leu Ser Lys Tyr Val Gly Phe Ile Asn Asp Lys Ser Glu 
                965                 970                 975     


Asp Val Leu Thr Glu Leu Lys Asp Phe Cys Arg Glu Lys Ile Asn Asn 
            980                 985                 990         


Gly Ser Gln Ile Ile Gly Ile Tyr  Tyr Gly Gly Asp Asn  Val Ile Ile 
        995                 1000                 1005             


Asn Arg  Asn Val Ile Tyr Ala  Gln Met Tyr Ser Asn  Ala Glu Val 
    1010                 1015                 1020             


Phe Ser  Asn Ile Tyr Lys Lys  Val Thr Lys Asn Asp  Ile Ile Asn 
    1025                 1030                 1035             


Tyr Tyr  Glu Lys Gln Asn Asp  Leu Lys Asp Val Phe  Lys Ser Gly 
    1040                 1045                 1050             


Val Cys  Gln Asn Glu Gly Glu  Gln Arg Ser Leu Cys  Glu Phe Gln 
    1055                 1060                 1065             


Gln Leu  Lys Asn Arg Ile Glu  Leu Thr Glu Leu Ser  Thr Tyr Ala 
    1070                 1075                 1080             


Asp Met  Val Asn Asp Phe Met  Ala Gln Phe Val Glu  Trp Ala Tyr 
    1085                 1090                 1095             


Leu Arg  Glu Arg Asp Leu Met  Tyr Phe Gln Leu Gly  Ile His Tyr 
    1100                 1105                 1110             


Ile Arg  Leu Phe Tyr Ser Asp  Asn Val Leu Asp Glu  Lys Tyr His 
    1115                 1120                 1125             


Lys Leu  Arg Asp Asn Val Ile  Asp Ile Glu Glu Gly  Ala Leu Leu 
    1130                 1135                 1140             


Tyr Gln  Ile Val Ala Met Tyr  Asp Tyr Glu Leu Arg  Ile Phe Glu 
    1145                 1150                 1155             


Thr Asp  Asn Ser Gly Asn Ala  Lys Arg Ile Gly Gln  Gly Gly Pro 
    1160                 1165                 1170             


Gly Lys  Ser Ile Pro Val Phe  Leu Lys Lys Tyr Cys  Asn Gly Thr 
    1175                 1180                 1185             


Asp Val  Tyr Glu Cys Gly Leu  Glu Leu Phe Glu Asp  Ile Asn Gln 
    1190                 1195                 1200             


His Glu  His Ile Ile Arg Phe  Arg Asn Asp Ile Ala  His Met Arg 
    1205                 1210                 1215             


Tyr Met  Ser Asn Gln Ala Met  Asn Ile Met Ser Ile  Val Ser Asn 
    1220                 1225                 1230             


Ile Tyr  Lys Ser Phe Phe Val  Tyr Asp Thr Lys Leu  Lys Lys Ser 
    1235                 1240                 1245             


Ile Ser  Leu Val Phe Lys Asn  Ile Leu Met Arg Tyr  Gly Val Ile 
    1250                 1255                 1260             


Ala Asp  Leu Val Phe Ser Tyr  Asn Asn Lys Asn Gln  Ser Ile Lys 
    1265                 1270                 1275             


Asp Asp  Met Asn Ile Asn Ile  Ile Asn Ile Lys Asn  Leu Lys Ser 
    1280                 1285                 1290             


Asp Lys  Tyr Val Tyr Lys Ile  Val Asn Glu Asp Ile  Val Lys Gln 
    1295                 1300                 1305             


Val Glu  Ile Glu Ile Arg Asn  Gln Val Phe Leu Glu  Gln Leu His 
    1310                 1315                 1320             


Lys Leu  Leu Tyr Phe Ser Arg  
    1325                 1330 


<210>  192
<211>  1199
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  192

Met Leu Arg Arg Met Cys Met Lys Ile Thr Lys Ile Asp Gly Val Ser 
1               5                   10                  15      


His Tyr Lys Lys Gln Asp Lys Gly Ile Leu Lys Lys Lys Trp Lys Asp 
            20                  25                  30          


Leu Asp Glu Arg Glu Gln Arg Glu Lys Ile Glu Ala Arg Tyr Asn Lys 
        35                  40                  45              


Gln Ile Glu Ser Lys Ile Tyr Lys Glu Phe Phe Arg Leu Lys Asn Gly 
    50                  55                  60                  


Lys Asp Ser Gly Arg Ile Thr Glu Glu Lys Asn Glu Gly Ile Lys Ser 
65                  70                  75                  80  


Leu Tyr Tyr Leu Ile Lys Glu Leu Tyr Glu Glu Lys Glu Asn Asp Leu 
                85                  90                  95      


Trp Glu Leu Lys Asn Ile Asn Leu Glu Ile Leu Asp Asp Lys Glu Arg 
            100                 105                 110         


Ile Ile Lys Gly Tyr Lys Phe Lys Glu Asp Val Tyr Phe Phe Lys Glu 
        115                 120                 125             


Gly Asp Lys Lys Tyr Tyr Leu Arg Thr Leu Leu Asn Asn Leu Ile Glu 
    130                 135                 140                 


Lys Asn Gln Asn Glu Asn Arg Asp Lys Val Arg Lys Asn Lys Glu Phe 
145                 150                 155                 160 


Ser Asp Leu Lys Glu Ile Phe Lys Lys Tyr Lys Asp Arg Lys Ile Lys 
                165                 170                 175     


Leu Leu Leu Glu Ser Ile Asn Asn Asn Lys Ile Asn Leu Glu Tyr Lys 
            180                 185                 190         


Lys Glu Asn Val Asn Glu Glu Ile Tyr Gly Ile Asn Pro Thr Asn Asp 
        195                 200                 205             


Arg Glu Met Thr Phe Tyr Glu Leu Leu Lys Glu Ile Ile Glu Lys Lys 
    210                 215                 220                 


Asp Glu Gln Lys Ser Ile Leu Glu Glu Lys Leu Asp Asn Phe Asp Ile 
225                 230                 235                 240 


Thr Asn Phe Leu Glu Asn Ile Glu Lys Ile Phe Asn Glu Glu Thr Glu 
                245                 250                 255     


Ile Asn Ile Ile Lys Gly Lys Val Leu Asn Glu Leu Arg Glu Tyr Ile 
            260                 265                 270         


Arg Glu Lys Glu Glu Asn Asn Ser Asp Tyr Lys Leu Lys Gln Ile Tyr 
        275                 280                 285             


Asn Leu Glu Leu Lys Lys Tyr Ile Glu Asn Asn Phe Ser Tyr Lys Lys 
    290                 295                 300                 


Gln Lys Ser Lys Ser Lys Asn Ser Glu Asn Asp Tyr Leu Tyr Leu Asn 
305                 310                 315                 320 


Phe Leu Lys Lys Ile Met Phe Ile Glu Glu Val Asp Glu Lys Lys Gly 
                325                 330                 335     


Ile Asn Lys Glu Lys Phe Lys Asn Lys Ile Asn Ser Asn Phe Lys Asn 
            340                 345                 350         


Leu Phe Val Gln His Ile Leu Asp Tyr Gly Lys Leu Leu Tyr Tyr Lys 
        355                 360                 365             


Glu Asn Asp Glu Tyr Ile Lys Asn Thr Gly Gln Leu Glu Thr Lys Asp 
    370                 375                 380                 


Leu Glu Tyr Ile Lys Thr Lys Glu Thr Leu Ile Arg Lys Met Ala Val 
385                 390                 395                 400 


Leu Val Ser Phe Ala Ala Asn Ser Tyr Tyr Asn Leu Phe Gly Arg Thr 
                405                 410                 415     


Glu Asn Asn Ile Leu Thr Gln Glu Ile Ser Asp Asp Leu Leu Leu Gly 
            420                 425                 430         


Lys Ile Glu Asn Glu Ile Tyr Ile Lys Gly Glu Lys Asn Arg Arg Tyr 
        435                 440                 445             


Val Phe Lys Glu Lys Met Leu Asn Tyr Phe Phe Asn Pro Glu Ile Phe 
    450                 455                 460                 


Gly Asp Asn Lys Ile Val Glu Leu Leu Ser Ala Ile Ser Ser Ser Ile 
465                 470                 475                 480 


Tyr Asn Ile Arg Asn Gly Val Asn His Phe Asp Lys Met Ile Leu Gly 
                485                 490                 495     


Lys Tyr Asn Asn Gly Leu Asp Leu Lys Asp Ser Asn Thr Ile Lys Asp 
            500                 505                 510         


Tyr Phe Asn Phe Lys Lys Lys Glu Ile Gln Gln Asp Leu Lys Asp Arg 
        515                 520                 525             


Phe Ile Ser Asn Asn Leu Gln Tyr Tyr Tyr Thr Glu Asn Glu Ile Lys 
    530                 535                 540                 


Lys Tyr Phe Glu Lys Tyr Lys Phe Glu Ile Leu Lys Thr Lys Ala Ser 
545                 550                 555                 560 


Phe Ala Pro Asn Phe Lys Arg Ile Leu Thr Lys Gly Glu Asn Leu Ser 
                565                 570                 575     


Ile Ser Glu Ser Asn Asn Ser Tyr Glu Phe Phe Lys Ala Tyr Ser Glu 
            580                 585                 590         


Asn Ser Asp Lys Asn Thr Glu Tyr Asn Glu Phe Met Lys Thr Arg Asn 
        595                 600                 605             


Phe Leu Leu Lys Glu Leu Tyr Tyr Asn Asn Phe Tyr Thr Glu Phe Leu 
    610                 615                 620                 


Asn Asn Lys Ala Lys Phe Arg Glu Ala Val Glu Lys Val Lys Lys Asn 
625                 630                 635                 640 


Lys Lys Arg Arg Gly Gly Lys Ser Tyr Asp Val Ile Gly Asn Tyr Asn 
                645                 650                 655     


Phe Ser Asp Asn Ile Pro Glu Tyr Ile Ser Tyr Ile His Lys Ser Glu 
            660                 665                 670         


Met Glu Arg Ile Glu Ile Asn Thr Glu Lys Asn Arg Lys Asp Thr Ser 
        675                 680                 685             


Arg His Ile Arg Asp Phe Ile Glu Glu Val Phe Leu Glu Gly Phe Ile 
    690                 695                 700                 


Lys Tyr Leu Asp Asn Asn Asn Phe Lys Phe Leu Lys Lys Arg Asn Glu 
705                 710                 715                 720 


Val Asp Lys Glu Arg Lys Glu Ile Val Arg Asn Leu Asn Ile Gln Ile 
                725                 730                 735     


Glu Gly Leu Asp Ile Leu Asn Glu Asn Asp Ser Glu Ile Leu Asn Leu 
            740                 745                 750         


Tyr Leu Phe Phe Asn Met Ile Asp Asn Lys Arg Ile Ser Glu Phe Arg 
        755                 760                 765             


Asn Asp Met Ile Lys Tyr Lys Gln Phe Leu Ala Lys Arg Gln Asn Thr 
    770                 775                 780                 


Glu Asn Lys Phe Leu Glu Ile Asp Ile Glu Lys Ile Glu Ala Ile Ile 
785                 790                 795                 800 


Glu Phe Val Ile Ile Thr Lys Glu Lys Leu Glu Ile Leu Glu Gly Glu 
                805                 810                 815     


Thr Lys Glu Gln Glu Lys Asp Asn Met Asn Ala Leu Phe Asn Lys Phe 
            820                 825                 830         


Tyr Ser Ser Ala Ser Glu Tyr Asp Glu Lys Leu Arg Lys Phe Ile Glu 
        835                 840                 845             


Glu Ala Ile Leu Asp Asp Lys Lys Asn Thr Pro Phe Tyr Ser Thr Asp 
    850                 855                 860                 


Gly Lys Thr Pro Ile Val His Gly Asn Leu Glu Lys Met Arg Lys Tyr 
865                 870                 875                 880 


Gly Thr Glu Asn Phe Leu Ser Lys Val Leu Lys Asp Asn Lys Tyr Thr 
                885                 890                 895     


Leu Asn Asn Met Thr Thr Lys Glu Lys Phe Glu Ala Glu Val Ser Asp 
            900                 905                 910         


Glu Leu Lys Glu Tyr Lys Ile Leu Glu Lys Val Asn Arg Phe Lys Glu 
        915                 920                 925             


Asn Gly Lys Pro Lys Lys Val Ile Glu Tyr Tyr Asn Asp Cys Arg Cys 
    930                 935                 940                 


Tyr Leu His Lys Glu Trp Ile Glu Lys Lys Lys Ser Glu Glu Glu Phe 
945                 950                 955                 960 


Glu His Lys Glu Ile Tyr Lys Lys Ile Ile Glu Glu Ile Arg Lys Tyr 
                965                 970                 975     


Asn Tyr Leu Glu Asn Lys Glu Lys Leu Gln Asn Val Tyr Leu Leu His 
            980                 985                 990         


Glu Ile Leu Ser Asp Leu Leu Ala  Arg Asn Val Ala Phe  Leu Asn Lys 
        995                 1000                 1005             


Trp Glu  Arg Asp Phe Lys Phe  Ile Val Ile Ala Ile  Lys Gln Phe 
    1010                 1015                 1020             


Leu Lys  Glu Asp Asp Lys Glu  Lys Val Asn Lys Phe  Leu Asn Pro 
    1025                 1030                 1035             


Cys Lys  Pro Asp Gly Ser Lys  Asp Asn Phe Ser Val  Thr Asn Tyr 
    1040                 1045                 1050             


Arg Asn  Lys Met Lys Ser Val  Ile Asn Lys Ile His  Glu Asn Phe 
    1055                 1060                 1065             


Met Ser  Leu Leu Phe Leu Asn  Asp Asn Leu Ala Ile  Arg Gly Ile 
    1070                 1075                 1080             


Thr Ala  Asp Asn Phe Thr Trp  Gly Asn Leu Arg Asn  Tyr Ile Ala 
    1085                 1090                 1095             


His Phe  Glu Tyr Leu His Lys  Glu Lys Asp Thr Ile  Ser Phe Ile 
    1100                 1105                 1110             


Thr Gln  Ala Asn Leu Leu Ile  Lys Leu Phe Ser Tyr  Asp Lys Lys 
    1115                 1120                 1125             


Val Gln  Asn Arg Ile Leu Glu  Ser Met Lys Lys Ile  Leu Lys Lys 
    1130                 1135                 1140             


Tyr Asn  Met Asp Ile Glu Phe  Lys Arg Asn Asp Glu  Asp Glu Glu 
    1145                 1150                 1155             


Leu Asn  Tyr Glu Ile Lys Glu  Thr Thr Ser Lys Lys  Gly Lys Leu 
    1160                 1165                 1170             


Leu Gly  Glu Glu Asn Lys Phe  Lys Leu Leu Glu Asn  Glu Phe Phe 
    1175                 1180                 1185             


Glu Asn  Val Glu Lys Met Leu  Gly Tyr Lys Asp 
    1190                 1195                 


<210>  193
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  193

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu Tyr Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Asn Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asn Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Val Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Val 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Gly Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Lys Ile Leu Lys Tyr Thr Glu Ser Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Ala Phe Ser Asp Gln Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Ile Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Asn His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Leu Lys Glu Leu Lys Glu Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn Tyr Thr Met Gln Gln Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Lys Lys Asp Glu Lys Phe Asn Asp Glu Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asn Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Lys Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Lys  Glu Leu Cys 
    1130                 1135                 1140             


Glu Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Glu  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  194
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  194

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Ile Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Phe Asp Phe Lys Leu  Leu Asn 
    1400                 1405                 1410         


<210>  195
<211>  1162
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  195

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Phe Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Glu 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Lys Asp Asp Ile Thr Gly Lys Ile Arg Gly Lys Thr Arg Ile Glu Ser 
                405                 410                 415     


Lys Thr Gly Glu Glu Lys Tyr Ile Pro Gly Glu Val Asp Lys Ile Tyr 
            420                 425                 430         


Asn Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr 
        435                 440                 445             


Ser Tyr Asp Phe Asn Leu Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe 
    450                 455                 460                 


Val Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His 
465                 470                 475                 480 


Phe Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile 
                485                 490                 495     


Ala Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu 
            500                 505                 510         


Lys Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val 
        515                 520                 525             


Phe Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr 
    530                 535                 540                 


Arg Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr 
545                 550                 555                 560 


Lys Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr 
                565                 570                 575     


Trp Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile 
            580                 585                 590         


Asp Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu 
        595                 600                 605             


Asn Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu 
    610                 615                 620                 


Ile Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe 
625                 630                 635                 640 


Tyr Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Lys 
                645                 650                 655     


Tyr Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln 
            660                 665                 670         


Asp Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe 
        675                 680                 685             


Leu Lys Gly Phe Met Thr Tyr Leu Ala Asn Ser Gly Arg Leu Ser Leu 
    690                 695                 700                 


Met Tyr Ile Gly Asn Asp Glu Gln Ile Asn Thr Ser Leu Ala Gly Lys 
705                 710                 715                 720 


Lys Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn 
                725                 730                 735     


Ile Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu 
            740                 745                 750         


Gly Lys Ile Leu Lys Tyr Thr Glu Ser Leu Asn Met Phe Tyr Leu Ile 
        755                 760                 765             


Leu Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu 
    770                 775                 780                 


Glu Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu 
785                 790                 795                 800 


Glu Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp 
                805                 810                 815     


Phe Glu Leu Glu Ala Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly 
            820                 825                 830         


Asn Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Lys Lys 
        835                 840                 845             


Ile Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn 
    850                 855                 860                 


Ile Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys 
865                 870                 875                 880 


Ala Lys Tyr Lys Ile Ser Leu Lys Glu Leu Lys Glu Tyr Ser Asn Lys 
                885                 890                 895     


Lys Asn Glu Ile Glu Lys Asn Ser Thr Met Gln Gln Asn Leu His Arg 
            900                 905                 910         


Lys Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Asn Asp Glu Asp Tyr 
        915                 920                 925             


Lys Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu 
    930                 935                 940                 


Lys Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu 
945                 950                 955                 960 


Leu Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg 
                965                 970                 975     


Asp Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile 
            980                 985                 990         


Glu Glu Ile Phe Asn Phe Asp Asn  Ser Lys Asn Val Lys  Tyr Lys Ser 
        995                 1000                 1005             


Gly Gln  Ile Val Glu Lys Tyr  Ile Asn Phe Tyr Lys  Glu Leu Tyr 
    1010                 1015                 1020             


Lys Asp  Asn Val Glu Lys Arg  Ser Ile Tyr Ser Asp  Lys Lys Val 
    1025                 1030                 1035             


Lys Lys  Leu Lys Gln Glu Lys  Lys Asp Leu Tyr Ile  Arg Asn Tyr 
    1040                 1045                 1050             


Ile Ala  His Phe Asn Tyr Ile  Pro His Ala Glu Ile  Ser Leu Leu 
    1055                 1060                 1065             


Glu Val  Leu Glu Asn Leu Arg  Lys Leu Leu Ser Tyr  Asp Arg Lys 
    1070                 1075                 1080             


Leu Lys  Asn Ala Val Met Lys  Ser Val Met Asn Ile  Leu Lys Glu 
    1085                 1090                 1095             


Tyr Gly  Phe Val Ala Lys Phe  Lys Ile Gly Ala Asp  Lys Lys Ile 
    1100                 1105                 1110             


Glu Ile  Gln Thr Leu Glu Ser  Glu Lys Ile Val His  Leu Lys Asn 
    1115                 1120                 1125             


Leu Lys  Lys Glu Lys Leu Thr  Thr Asn Arg Asn Ser  Lys Glu Leu 
    1130                 1135                 1140             


Cys Lys  Leu Val Lys Val Met  Phe Glu Tyr Lys Met  Glu Glu Lys 
    1145                 1150                 1155             


Lys Ser  Glu Asn 
    1160         


<210>  196
<211>  1064
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  196

Met Arg Gly Asp Tyr Met Lys Ile Thr Lys Ile Asp Gly Ile Ser His 
1               5                   10                  15      


Lys Lys Tyr Lys Glu Lys Gly Lys Leu Ile Lys Ser Asn Glu Ile Glu 
            20                  25                  30          


Lys Asp Val Thr Glu Glu Arg Phe Asn Asp Ile Glu Val Lys Thr Thr 
        35                  40                  45              


Glu Leu Phe Gln Lys Thr Leu Asp Phe Tyr Val Lys Asn Tyr Glu Lys 
    50                  55                  60                  


Cys Glu Glu Gln Asn Lys Glu Arg Arg Glu Lys Ala Lys Asn Tyr Phe 
65                  70                  75                  80  


Ser Lys Val Lys Leu Ile Val Asp Asn Lys Lys Ile Thr Ile Phe Asn 
                85                  90                  95      


Glu Asn Thr Glu Lys Ile Glu Ile Glu Gly Phe Asn Glu Tyr Asp Val 
            100                 105                 110         


Arg Asp Glu Lys Tyr Phe Asn Val Leu Asn Lys Ile Leu Lys Glu Glu 
        115                 120                 125             


Asn Cys Thr Glu Glu Asp Leu Glu Val Phe Glu Asn Asp Leu Gln Lys 
    130                 135                 140                 


Lys Leu Asn Gln Ile Gln Ser Ile Lys Asn Ser Leu Glu Glu Asn Lys 
145                 150                 155                 160 


Ala His Phe Lys Lys Glu Ser Val Asn Asn Thr Ala Asp Arg Val Lys 
                165                 170                 175     


Gly Asn Asn Lys Lys Ser Leu Phe Tyr Glu Tyr Tyr Arg Asn Ser Ser 
            180                 185                 190         


Lys His Gln Glu Tyr Val Asn Asn Ile Phe Glu Ala Phe Asp Lys Leu 
        195                 200                 205             


Tyr Ser Asn Ser His Glu Asp Met Asn Asn Leu Phe Ser Ala Ile Thr 
    210                 215                 220                 


Lys Asp Ser Asn Asp Arg Asn Ile Lys Lys Ile Arg Glu Ala Tyr His 
225                 230                 235                 240 


Glu Ile Leu Asn Lys Asn Lys Ile Glu Phe Gly Glu Glu Leu Tyr Lys 
                245                 250                 255     


Lys Ile Gln Asp Asn Ile Asn Asn Phe Asp Lys Leu Leu Glu Ile Glu 
            260                 265                 270         


Pro Glu Ile Lys Glu Leu Thr Lys Ser Gln Ile Phe Tyr Lys Tyr Tyr 
        275                 280                 285             


Ile Asp Lys Val Ser Leu Asp Gly Thr Asn Ile Lys His Cys Phe Ser 
    290                 295                 300                 


His Leu Val Glu Ile Glu Val Asn Gln Leu Leu Lys Asn Tyr Val Tyr 
305                 310                 315                 320 


Ser Lys Arg Ser Thr Asn Lys Glu Lys Leu Glu Asn Ile Phe Glu Tyr 
                325                 330                 335     


Cys Lys Leu Lys Asn Leu Val Lys Asn Lys Leu Val Asn Lys Leu Asn 
            340                 345                 350         


Ser Tyr Ile Arg Asn Cys Gly Lys Tyr Asn Ser Tyr Ile Asn Asn Asn 
        355                 360                 365             


Asp Val Val Asn Ser Glu Lys Ile Ser Glu Ile Arg Thr Lys Glu Ala 
    370                 375                 380                 


Phe Leu Arg Ser Ile Ile Gly Val Ser Ser Ser Ala Tyr Phe Ser Leu 
385                 390                 395                 400 


Arg Asn Ile Leu Asn Thr Asp Asn Thr Gln Asp Ile Thr Asn Lys Val 
                405                 410                 415     


Lys Gly Glu Val Glu Lys Leu Tyr Gln Glu Asn Lys Lys Val Lys Leu 
            420                 425                 430         


Glu Glu Arg Leu Lys Leu Phe Phe Gly Asn Asn Phe Asp Ile Asn Asn 
        435                 440                 445             


Gln Gln Glu Ile Glu Asp Phe Leu Met Asn Ile Asp Lys Ile Ile Ser 
    450                 455                 460                 


Asn Ile Arg His Glu Ile Ile His Phe Lys Ile Glu Ala Asn Ala His 
465                 470                 475                 480 


Ser Ile Phe Asp Phe Asn Asn Val Thr Leu Gly Asn Lys Ala Lys Asn 
                485                 490                 495     


Ile Phe Asn Asn Glu Ile Asn Glu Glu Arg Ile Lys Phe Lys Ile Phe 
            500                 505                 510         


Lys Gln Leu Asn Ser Ala Asn Val Phe Asp Tyr Leu Ser Asp Glu Asn 
        515                 520                 525             


Ile Thr Glu Tyr Met Gly Lys Val Ile Phe Ser Phe Thr Asn Arg Asn 
    530                 535                 540                 


Ile Pro Phe Val Pro Ser Phe Arg Lys Ile Tyr Asn Arg Val Gln Asp 
545                 550                 555                 560 


Leu Ala Asn Ser Leu Lys Ile Lys Glu Trp Lys Ile Ser Asp Glu Ser 
                565                 570                 575     


Glu Gly Lys Asp Ala Gln Ile Tyr Leu Leu Lys Asn Ile Phe Leu Asp 
            580                 585                 590         


Phe Ile Gln Lys Ile Phe Leu Lys Gly Phe Phe Glu Phe Ile Lys Asn 
        595                 600                 605             


Asn Tyr Asn Tyr Leu Leu Glu Leu Lys Lys Ile Gln Asp Lys Lys Asn 
    610                 615                 620                 


Ile Phe Asp Ser Glu Met Ser Glu Tyr Ile Ala Gly Glu Lys Thr Leu 
625                 630                 635                 640 


Glu Asp Val Gly Glu Ile Asn Glu Ile Ile Gln Lys Ile Glu Ile Met 
                645                 650                 655     


Lys Ile Asp Lys Ile Leu Asn Leu Thr Asp Lys Ile Asn Cys Phe Tyr 
            660                 665                 670         


Leu Leu Leu Lys Leu Leu Asn Tyr Lys Glu Ile Thr Glu Leu Lys Gly 
        675                 680                 685             


Asn Leu Glu Lys Tyr Gln Ile Leu Ser Lys Thr Asp Ile Tyr Glu Lys 
    690                 695                 700                 


Glu Leu Ile Leu Leu Asn Ile Val Asn Leu Asp Asn Asn Lys Val Lys 
705                 710                 715                 720 


Ile Glu Lys Phe Lys Ile Ser Ala Glu Glu Ile Gly Lys Phe Ile Glu 
                725                 730                 735     


Lys Ile Ser Arg Asn Lys Lys Ile Lys Thr Phe Glu Glu Leu Arg Asn 
            740                 745                 750         


Phe Glu Lys Arg Glu Asn Thr Gly Glu Tyr Tyr Asn Val Tyr Ser Asp 
        755                 760                 765             


Asp Lys Asn Ile Lys Asn Ile Arg Asn Leu Tyr Asn Ile Lys Lys Tyr 
    770                 775                 780                 


Gly Met Leu Asp Leu Leu Glu Arg Ile Ser Glu Lys Ser Asn Tyr Cys 
785                 790                 795                 800 


Ile Lys Lys Glu Asp Leu Glu Glu Tyr Ser Glu Leu Arg Lys Gln Leu 
                805                 810                 815     


Glu Asp Glu Lys Thr Asn Phe Tyr Lys Ile Gln Lys Asp Leu His Tyr 
            820                 825                 830         


Glu Tyr Gln Lys Lys Tyr Lys Asn Phe Ser Lys Lys Asn Asn Pro Glu 
        835                 840                 845             


Asp Tyr Glu Lys Tyr Lys Glu Ser Ile Lys Asn Ile Glu Lys Tyr Val 
    850                 855                 860                 


His Leu Lys Asn Lys Ile Glu Phe Asn Glu Leu Asn Leu Leu Gln Ser 
865                 870                 875                 880 


Leu Leu Leu Lys Ile Leu His Arg Leu Val Gly Phe Thr Ser Ile Trp 
                885                 890                 895     


Glu Arg Asp Leu Arg Phe Arg Leu Ile Gly Glu Phe Pro Asp Glu Leu 
            900                 905                 910         


Asp Val Glu Asp Ile Phe Asp His Arg Glu Arg Tyr Arg Gly Thr Arg 
        915                 920                 925             


Gly Gln Ile Cys Lys Lys Tyr Asp Gln Phe Ile Ser Val His Ile Glu 
    930                 935                 940                 


Tyr Gln Asn Asn Asn Lys Met Lys Asn Ile Lys Phe Asp Asp Asn Asn 
945                 950                 955                 960 


Pro Ile Arg Asn Tyr Ile Ala His Phe Asn Tyr Leu Pro Thr Pro Lys 
                965                 970                 975     


Tyr Ser Ile Leu Lys Met Leu Gly Lys Leu Arg Glu Leu Leu Asp Tyr 
            980                 985                 990         


Asp Arg Lys Leu Lys Asn Ala Val  Met Lys Ser Ile Lys  Asp Ile Leu 
        995                 1000                 1005             


Glu Glu  Tyr Gly Phe Lys Ala  Glu Phe Val Ile Asn  Pro Asp Lys 
    1010                 1015                 1020             


Glu Ile  Ile Leu Asn Ser Val  Lys Ser Val Glu Ile  Ile His Leu 
    1025                 1030                 1035             


Lys Lys  Asn Asp Leu Asn Ser  His Arg Asn Ser Glu  Asp Leu Cys 
    1040                 1045                 1050             


Lys Leu  Val Lys Ala Met Leu  Glu Tyr Ser Glu 
    1055                 1060                 


<210>  197
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  197

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Asp Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn Tyr Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Gly Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Gly Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Lys Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Arg Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Asp Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  198
<211>  1416
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  198

Leu Gly Arg Glu Trp Phe Leu Leu Pro Ser Pro Lys Ile Thr Asn Leu 
1               5                   10                  15      


Ser Pro Val Asn Arg Arg His Phe Met Lys Ile Leu Arg Ser Lys Gly 
            20                  25                  30          


Gln Ser Tyr Thr Gln Lys Ser Ala Ala Val Gly His Glu Gly Gly Glu 
        35                  40                  45              


Leu Gly Arg Gly Leu Lys Pro Phe Asn Ser Thr Gly Ser Ser Gly Glu 
    50                  55                  60                  


Ile Asp Pro Ser Ser Leu Val Asn Phe Ile Val Ser Asp Pro Asp Leu 
65                  70                  75                  80  


Ala Met Arg Gln Leu Val Ser Ala Leu Asp Lys Val Val Arg Lys Arg 
                85                  90                  95      


Pro Leu Arg Ala Phe Asn Val Asn Ala Tyr Val Asp Arg Val Lys Ile 
            100                 105                 110         


Ala Ala Tyr Leu Trp Arg Leu Leu Lys Pro His Leu Pro Glu Glu Ile 
        115                 120                 125             


Arg Glu Leu Gly Gln Thr Asn Lys Thr Trp Met Ser Arg Val His Ser 
    130                 135                 140                 


Ser Tyr Ala Thr Asp Glu Ile Asp Glu Ala Ser Pro Lys Thr Asp Lys 
145                 150                 155                 160 


Asn Ala Ala Ile Ile Glu Lys Tyr Ala Glu Lys Ala Asn Asn Asp Phe 
                165                 170                 175     


Lys Leu Gly Thr Ala Gly Ala Arg Pro Ala Ala Thr Arg Glu Ser Leu 
            180                 185                 190         


Arg Gly Met Trp His Asp Ser Leu Trp Arg Pro Ser His Glu Asp Thr 
        195                 200                 205             


Ala Gln Ala Ile Phe Asp His Val Phe Thr Gln Glu Met Leu Ile Arg 
    210                 215                 220                 


Arg Ala Glu Lys Asp Pro Pro Asp Asn Phe Arg Ser Ser Lys Gly Lys 
225                 230                 235                 240 


Ser Asn Ala Ser Gly Arg Gly Leu Ala Ala Ala Arg Ala Glu Ser Met 
                245                 250                 255     


Ala Lys Ser Val His Asp Pro Arg Val Lys Lys Gly Glu Glu Pro Lys 
            260                 265                 270         


Lys Lys Arg Asp Trp Arg Asp Glu His Ala Glu Ile Tyr Phe Lys Lys 
        275                 280                 285             


Leu Pro Leu Thr Pro Glu Ser Ser Arg Lys Val Asp Val Ala Glu Arg 
    290                 295                 300                 


Ile Ile Leu Ala Leu Gln Asp His Val Glu Arg Asn Ala Ala Asn Leu 
305                 310                 315                 320 


Gly Ser Ile Ile Gly Arg Ala Ile Phe Glu His Phe Gly Ala Leu Lys 
                325                 330                 335     


Gly Thr Tyr Glu Arg Asp Asp Glu Asn Val Arg His Leu Val Asn Leu 
            340                 345                 350         


Asn Asn Ala Val Arg Thr Phe Tyr Ala Asp Leu Ala Asp Thr Gln Arg 
        355                 360                 365             


Leu Arg Ile Ala Phe Asp Pro Lys Leu Arg Glu Arg His Asn Gln Arg 
    370                 375                 380                 


Lys Leu Thr Ala Lys Gly Asp Pro Gly Asp Ala Gly Asp Gly Phe Thr 
385                 390                 395                 400 


Arg Leu Leu Pro Ala Asp Ala Gly Ala Leu Arg Glu Lys Met Ala Ala 
                405                 410                 415     


Val Asp Gly Asn Arg Asp Ile Ser Arg Trp Ile Arg Leu Gly Arg Leu 
            420                 425                 430         


Val Val His Ala Ala Asp Ala Asp Asp Asn Ser Lys Phe Asn Gln Ala 
        435                 440                 445             


Glu Phe Glu Arg Arg Leu Asp Tyr Phe Ala Thr Ser Ala Gly Gln Ser 
    450                 455                 460                 


Gln Ile Lys Arg Asn Glu Thr Phe Ala Arg Val Trp Arg Ser Ala Ala 
465                 470                 475                 480 


Thr Met Ser Leu Arg Thr Leu Lys Ala Trp Ala Asp Pro Asp Asn Lys 
                485                 490                 495     


Ala Val Lys Leu Ala Ala Ser Glu Ala Gln Thr Asp Asn Arg Asp Ile 
            500                 505                 510         


Ala Ala Glu Glu Val Ser Glu Ile Ala Ile Lys Asn Leu Asn Thr His 
        515                 520                 525             


His Phe Asn Ala Phe Asn Ala Val Leu Phe Gly Asp Arg Leu Ile Lys 
    530                 535                 540                 


Gly Gln Ser Arg Ala Ser Leu Phe Thr Ala Thr Glu Asp Ser Lys Asp 
545                 550                 555                 560 


Gln Ala Gln Arg Asp Met Arg Ala Phe Leu Arg Leu Gly Ser Gly Met 
                565                 570                 575     


Arg Asn Ala Ile Ser His Leu Ile Thr Lys Pro Arg Leu Ala Arg Leu 
            580                 585                 590         


Leu Lys Val Gly Ile Val Ser Asp Ala Gly His Val Pro Lys His Thr 
        595                 600                 605             


Ala Glu Lys Leu Lys Lys Leu Phe Thr Phe Asp Lys Asn Leu Arg Arg 
    610                 615                 620                 


Tyr Met Ile Ala Gln Glu Leu Asp Arg Leu Gln Ile Ala Arg Phe Ala 
625                 630                 635                 640 


Asn Glu Thr Gln Val Gly Asn Phe Ile Gln Gln Phe Ser Met Leu Pro 
                645                 650                 655     


Leu Ala Glu Pro Val Pro Val Pro Arg Phe Met Ser Val Leu Ala Arg 
            660                 665                 670         


Ala Arg Ala Leu Gly Asp His Val Gln Lys Glu Val Ser Lys Asp Arg 
        675                 680                 685             


Lys Gly Thr Gln Val Arg Leu Asn Glu Thr Ile Asp Asp Ala Leu Arg 
    690                 695                 700                 


Gly Leu Ala Lys Val Gln Val Asp Pro Glu Thr Gln Ala Gly Gln Gly 
705                 710                 715                 720 


Pro Glu Ser Cys Lys Leu Gly Leu Leu Arg His Leu Tyr Asp Thr Gly 
                725                 730                 735     


Phe Arg Asn Trp Leu Ala Arg Asp Gly Ser Gly Arg Thr Glu Val Lys 
            740                 745                 750         


Ala Val Leu Ala Thr Leu Ala Lys Ser Lys Ala Gln Arg Val Asn Ala 
        755                 760                 765             


His Lys Thr Glu Lys Arg Leu His Phe Thr Pro Asp Asp Ser Leu Val 
    770                 775                 780                 


Gln Thr Leu Leu Asp Glu Gly Tyr Asp Ser Leu Pro Glu Leu Phe Ala 
785                 790                 795                 800 


Glu Leu Asp Ala Arg Ser Ala Gln Leu Gln Arg Ser Phe Asn Arg Phe 
                805                 810                 815     


Lys Ser Asp Thr Lys Ala Gln Arg Gln Lys Ser Gly Trp Val Asp Glu 
            820                 825                 830         


Phe Lys Gln Glu Leu Phe Ala His Leu Phe Ala Leu Tyr Ile Gln Lys 
        835                 840                 845             


Ala Gly Phe Asp Trp Leu Tyr Ser Leu Thr Ala Arg Asp Ser Ile Ser 
    850                 855                 860                 


Ser Val Lys Pro Ile Asp Pro Ala Thr Ile Ser Leu Pro Glu Leu Pro 
865                 870                 875                 880 


Asn Gln Glu Trp His Glu Arg Phe His Ala Trp Leu Tyr Leu Leu Pro 
                885                 890                 895     


Leu Ala Glu Val Ser Lys Leu Arg His Gln Met Ile Lys Ser Arg Val 
            900                 905                 910         


Leu Glu Ile Lys Gly Ser Asp Gln Pro Asn Glu Gly Glu Gln Lys Val 
        915                 920                 925             


Leu Ala Glu Ala Asp Met Leu Met Ala Leu His Leu Ser Val Arg Asp 
    930                 935                 940                 


Ala Gly Tyr Ala Gly Glu Glu His Lys Pro Leu Leu Asp Leu Leu Ala 
945                 950                 955                 960 


Lys Ala Asn Pro Lys Thr Asp Phe Arg Thr Leu Val Tyr Gly Asp Val 
                965                 970                 975     


Ala Asn Phe Glu Lys Leu Met Ser Thr Glu Lys Asp Asp Gln Asn Phe 
            980                 985                 990         


Ser Leu Ala Gly Thr Arg Arg Gly  Leu Arg Asp Met Leu  Arg Val Gly 
        995                 1000                 1005             


Asn Ala  Ala Ile Leu Ser Ser  Ile Phe Lys Tyr His  Pro Leu Gly 
    1010                 1015                 1020             


Pro Glu  Glu Ile Gly Leu Phe  Ala Asp Lys Ala Gln  Arg Asp Ala 
    1025                 1030                 1035             


Ser Gly  Arg Ala Ala Ser Leu  Arg Asp Asp Leu Lys  Lys Gln Leu 
    1040                 1045                 1050             


Leu Asp  Val Tyr His Gln Trp  Thr Pro Lys Gly Thr  Glu Ala Glu 
    1055                 1060                 1065             


Thr Gln  Arg Asn Asp Ala Leu  Lys Thr Leu Ala Lys  His Tyr Gln 
    1070                 1075                 1080             


Ala Ala  Ala Thr Asp Ala Ala  Met Lys Gly Phe Cys  Ser His Ala 
    1085                 1090                 1095             


Ala Arg  Leu Gly Asp His Leu  Ala Leu His Asp Leu  Ile Met Arg 
    1100                 1105                 1110             


Ile Ser  Ala Arg Leu Ala Asp  Tyr Ala Trp Leu Trp  Glu Arg Asp 
    1115                 1120                 1125             


Arg Ala  Tyr Val Tyr Leu Gly  Met Leu Trp Asp Asn  Met Gly Gly 
    1130                 1135                 1140             


Arg Leu  Glu Ile Ser Val Gln  Pro Gly Thr Lys Ser  Lys Ala Met 
    1145                 1150                 1155             


Thr Val  Ser Val Thr Ala Pro  Gln Asn Lys Ser Phe  Ala Leu Trp 
    1160                 1165                 1170             


Asn Glu  Asn Gly Ala Phe Ala  Thr Asp Lys Ser Arg  Ala Phe Asp 
    1175                 1180                 1185             


Leu Lys  Asn Leu Ser Pro Glu  His Glu Asp Ile Phe  Arg Asp His 
    1190                 1195                 1200             


Phe Ile  Gly Arg Glu Glu His  Pro Lys Asp Arg Ala  Arg Ile Lys 
    1205                 1210                 1215             


Glu Leu  Met Lys Ala Gly Thr  Thr Phe His Val Pro  Arg Val Ser 
    1220                 1225                 1230             


Leu Gly  Pro Val Arg Ile Arg  Asn Asp Phe Ala His  Phe Asn Phe 
    1235                 1240                 1245             


Leu Ser  Phe Ala Asn Pro Lys  Asp Thr Lys Gln Asp  Asn Asn Asp 
    1250                 1255                 1260             


Asp Thr  Ile Asn Arg Thr Pro  Asn Phe Thr Tyr Leu  Val Asn Ala 
    1265                 1270                 1275             


Ala Arg  Ser Leu Val Ser His  Asp Arg Lys Leu Lys  Asn Ala Val 
    1280                 1285                 1290             


Ala Lys  Ser Ile Ala Glu Ile  Ile Glu Asp Glu Gly  Leu Glu Ile 
    1295                 1300                 1305             


Thr Trp  Thr Leu Gly His Glu  Arg Leu Arg Lys Ala  Arg Val Ala 
    1310                 1315                 1320             


Pro Arg  Leu Met Pro His Leu  Glu Phe Leu Pro Arg  Asp Leu Asp 
    1325                 1330                 1335             


Asp Cys  Arg Phe Ala Leu Pro  Arg Val Ser Ala Arg  Tyr Ala Ser 
    1340                 1345                 1350             


Met Val  Lys Ala Leu Phe Asp  His Asp His Gly Gly  Asn Arg Thr 
    1355                 1360                 1365             


Arg Glu  Lys Thr Gly Lys Lys  Asp Lys Asp Asp Lys  Asp Ile Tyr 
    1370                 1375                 1380             


Ala Ala  Arg Gly Pro Leu Lys  Tyr Pro Ala Phe Pro  Lys Glu Ser 
    1385                 1390                 1395             


Arg Val  Pro Pro Glu Ile Gly  Ser Trp Ser Ala Tyr  His Gly Arg 
    1400                 1405                 1410             


Asp Lys  Ala 
    1415     


<210>  199
<211>  1400
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  199

Met Ala Lys His Leu Arg Pro Ile Ser Glu Ser Tyr Thr Asp Phe Arg 
1               5                   10                  15      


Glu Pro Glu Arg Asp Arg Arg Leu Gly Arg Gly Leu His His Asp His 
            20                  25                  30          


Glu Gly Asp Gln Ile Arg Pro Ala Ala Leu Pro Gly Tyr Leu Ser Ala 
        35                  40                  45              


Asn Pro Lys Ala Leu Leu Arg Gln Thr Ile Ala Val Leu Asp Lys Val 
    50                  55                  60                  


Val Lys Lys Arg Asn Arg Leu Ser Ala Met His Pro Glu Ala Tyr Arg 
65                  70                  75                  80  


Asp Arg Val Tyr Leu Ala Glu Ala Leu Trp Met Arg Leu Ile Ala Arg 
                85                  90                  95      


Ile Arg Glu Val Glu Lys Ile Asp Glu Ala Glu Ile Ser Glu Leu Arg 
            100                 105                 110         


Arg Leu Trp Asn Ala Lys Ser His Pro Tyr Ala Met Tyr Glu Val Val 
        115                 120                 125             


Pro Ser Gly Pro Leu Asn Asp Arg Asn Gly Gln Ala Ile Gln Lys Tyr 
    130                 135                 140                 


Arg Asp Ala Asp Gly Pro Gln Asp Pro Val Ile Ala Arg Thr Asp Phe 
145                 150                 155                 160 


Glu Gly Val Trp His Gly Arg Phe Trp Gln Glu Glu Pro Gly Arg Val 
                165                 170                 175     


Asp Tyr Gly Ala Ile Ala Asp Arg Ile Ile Ala His Leu Phe Asp Gln 
            180                 185                 190         


Glu Val Val Ile Gly Gly Gly Pro Arg Arg Ile Gly Ser Val Ser Val 
        195                 200                 205             


Pro Lys Gly Asp Pro Asn Gly Thr Pro Gly Pro Glu Thr Arg Arg Gly 
    210                 215                 220                 


Leu Ile Val Ala Arg Gly Glu Ala Ile Ser Arg Ser Ala Ser Asp Pro 
225                 230                 235                 240 


Arg Thr Pro Ser Gly Lys Leu Gln Ala Gln Ala Thr Trp Thr Thr Cys 
                245                 250                 255     


Ala Glu Ala Arg Tyr Phe Gly Asp Asp Gly Lys Gly Gly Ser Asp Ile 
            260                 265                 270         


Ala Lys Ala Ile Phe Glu Glu Leu Glu Lys Pro Glu Asn His Ala Gly 
        275                 280                 285             


Pro Ile Tyr Pro Ser Trp Phe Gly Ser Arg Leu Phe Asp His Phe Gly 
    290                 295                 300                 


Ser Phe Lys Lys Ser Leu Pro Leu Glu Arg Lys Asp Pro Phe Lys Asp 
305                 310                 315                 320 


Gln Ile Trp Ala Leu His Asn Ala Val Arg Gln Tyr Tyr Gln Arg Leu 
                325                 330                 335     


Ala Lys Ser Asp Arg Phe Arg Ile Ala Leu Arg Lys Ala Gln Ala Asp 
            340                 345                 350         


Val Pro Asp Lys Ser Glu Leu Leu Ser Leu Leu Pro Lys Asp Arg Gln 
        355                 360                 365             


His Leu Leu Leu Val Leu Gly Gly Lys Lys Arg Asn Ala Glu Met Ser 
    370                 375                 380                 


Glu Phe Ile Arg Leu Gly Lys Leu Phe Val His Ala Ser Asp Ala Leu 
385                 390                 395                 400 


His Asp Phe Arg Glu Asp Asp Pro Ala Ala Leu Glu Ala Phe Glu Lys 
                405                 410                 415     


Arg Met Thr Phe Leu Ala Thr Ser Ile Gly Gln Ser Glu Ile Lys Gln 
            420                 425                 430         


Ile Glu Thr Phe Ala Arg Thr Trp Arg Asn Ala Val Gly Leu Thr Leu 
        435                 440                 445             


Arg Thr Leu Lys Gly Leu Ala Asp Pro Lys Gly Lys Met Gly Asn Asp 
    450                 455                 460                 


Glu Asn Arg Asp Leu Cys Thr Lys Asp Val Met Arg Glu Val Val Asp 
465                 470                 475                 480 


Asp Asp Tyr Glu Lys Phe Asp Gln Asp Gln Phe Glu Arg His Ile Pro 
                485                 490                 495     


Ile Ile Phe Gly Ala Lys Tyr Leu Pro Asp Gly Lys Arg His Leu Pro 
            500                 505                 510         


Asp Gly Lys Arg Arg Ser Arg Ala Ser Ile Phe Thr Gly Asn Arg Asp 
        515                 520                 525             


Lys Ser His Gln Ala Glu Leu Leu Trp Ala Met Met Cys Val Val Arg 
    530                 535                 540                 


Ser Val Arg Asn Arg Thr Asn His Phe Asn Val Arg Arg Ala Leu Leu 
545                 550                 555                 560 


Arg Leu Leu Glu Asn Gly Ile Val His Pro Ile Ala Gly Asp Pro Ser 
                565                 570                 575     


Lys Gln Asn Ala Asp Ser Arg Asn Leu Gln His Val Ser Pro Ala Ala 
            580                 585                 590         


Leu Asp Ala Phe Lys Glu Leu Leu Lys Phe Asp Leu Ala Ile Gln Lys 
        595                 600                 605             


Asp Ala Val Arg Thr Ala Leu Lys Gln Ala Lys Ala Asp Glu Phe Val 
    610                 615                 620                 


Glu Met Asp Asn Leu Lys His Leu Val Ala His Leu Ser Gly Thr Asp 
625                 630                 635                 640 


Asp Ile Thr Val Leu Asn Ile Pro Arg Phe Ala Ala Val Met Asp Lys 
                645                 650                 655     


Val Arg Arg Leu Ala Asp Asn Asn Asp Val Asp Leu Ala Pro Gly Leu 
            660                 665                 670         


Val Thr Leu Gln Lys Ser Leu Pro Pro Lys Asp Asp Gln Lys Glu Ser 
        675                 680                 685             


Asp Ala Ala Arg Cys Arg Tyr Arg Leu Leu Leu Glu Leu Tyr Gln Ser 
    690                 695                 700                 


Gly Phe Arg Gly Trp Leu Ser Gly Ile Gln Ser Asp Ala Glu Arg Asn 
705                 710                 715                 720 


Arg Glu Leu Cys His Trp Ala Val Leu Gln Val Gly Arg Ser Lys Asp 
                725                 730                 735     


Ala Arg Lys Thr Lys Tyr Asp Ala Arg Thr Lys Arg Tyr Tyr Arg Ser 
            740                 745                 750         


Pro Ile Ser Leu Ile Asp Asp Leu Gly Leu Asp Arg Tyr Asp Asp Ile 
        755                 760                 765             


Ser Ala Leu Leu Asp Ala Leu Ala Ala Gln Ser Thr Arg Glu Gln Gly 
    770                 775                 780                 


Gln Asp Leu Arg Tyr Ser Pro Asp Ala Arg Val Gln Arg Gln Gly Ala 
785                 790                 795                 800 


Asn Arg Ile Glu Glu Phe Arg Gln Glu Leu Phe Ala His Ile Phe Ala 
                805                 810                 815     


Arg Tyr Leu Ala Glu Pro Gly Pro Glu Asp Pro Asp Phe Gly Trp Ile 
            820                 825                 830         


Gly Glu Ile Asp Thr Lys Arg Asp Cys Cys Asp Leu Ser Val Ala Leu 
        835                 840                 845             


Asp Gly Phe Gln Pro Pro Glu Gln Ala Phe Arg Ala Asp Trp His Ser 
    850                 855                 860                 


Gln Phe Tyr Ala Trp Leu Tyr Met Val Pro Pro Ile Glu Ala Ser Arg 
865                 870                 875                 880 


Leu Arg His Gln Met Arg Lys Ser Ala Ser Met Asp Gly Lys Trp Ser 
                885                 890                 895     


Glu Thr Leu Glu Leu Ser Cys Gly Glu Arg Lys Glu Arg Asp Glu Arg 
            900                 905                 910         


Ala Gln Gly Ile Leu Ala Asp Met Asp Arg Leu Phe Ser Leu Tyr Thr 
        915                 920                 925             


Lys Val Gln Ala Ala Gly Phe Ser Gly Gln Glu His Glu Gly Ala Leu 
    930                 935                 940                 


Glu Glu Lys Gly Leu Phe Tyr Gln Asp Ala Ser Phe Phe Lys Glu Val 
945                 950                 955                 960 


Tyr Gln Glu Glu Gly Thr Ala Asn Tyr His Thr Thr Phe Pro Gly Thr 
                965                 970                 975     


Arg Ser Gly Leu Arg Gln Leu Val Arg Tyr Ala His Leu Pro Pro Leu 
            980                 985                 990         


Thr Gly Ile Phe Glu Lys His Lys  Val Thr Ala Gly Glu  Val Lys Ser 
        995                 1000                 1005             


Phe Ala  Gly Leu His Asn Glu  Lys Arg Arg Asp Pro  Asp Lys Ile 
    1010                 1015                 1020             


Asn Cys  Val Lys Gln Arg Glu  Ser Phe Arg Gly Glu  Ile Leu Gln 
    1025                 1030                 1035             


Ser Ile  Lys Asp Ile Pro Lys  Pro Lys Asp Lys Ser  Tyr Ser Lys 
    1040                 1045                 1050             


Phe Leu  Ser Asp Leu Glu Glu  Lys Cys Arg Asn Tyr  Gln Thr Val 
    1055                 1060                 1065             


Ala Thr  Ala Ala Ala Ile His  Asn Phe Gln Ala Asn  Gly Ala Arg 
    1070                 1075                 1080             


Leu Asn  Asp His Val Arg Leu  His Gln Ile Val Met  Arg Val Leu 
    1085                 1090                 1095             


Thr Arg  Leu Thr Asp Tyr Ala  Leu Ile Trp Glu Arg  Asp Arg Leu 
    1100                 1105                 1110             


Phe Ala  Phe Val Gly Met Leu  Tyr Lys Glu Thr Gly  Gly Thr Gly 
    1115                 1120                 1125             


Leu Lys  Pro Ala Phe Gly Pro  Gly Ile Lys Arg Asn  Ala Ser Pro 
    1130                 1135                 1140             


Gln Ile  Gly Ile Leu Val Thr  Ala Pro Asp Leu Leu  Arg Arg Ser 
    1145                 1150                 1155             


Lys Thr  Glu Pro Gly Gln Val  Phe Ile Pro Tyr Leu  Asp Pro Glu 
    1160                 1165                 1170             


Thr Gly  Phe Asp Ala Pro Pro  Phe Glu Glu Arg Cys  Lys Met Leu 
    1175                 1180                 1185             


Ser Glu  Asp His Ala Arg Lys  Phe Gln Leu His Phe  Ile Asp Ala 
    1190                 1195                 1200             


Gly Glu  Arg Pro Ser Asp Leu  Thr Leu Arg Ser Asn  Glu Lys Pro 
    1205                 1210                 1215             


Gly Gly  Tyr Asp Ala Cys Lys  Thr Phe Lys Arg Gly  Thr Arg Lys 
    1220                 1225                 1230             


Lys Thr  Ile Arg Asp Asp Leu  Ala His His Asn Ile  Leu Asp Leu 
    1235                 1240                 1245             


Pro Gly  Arg Arg Gly Leu Asn  Leu Thr Tyr Val Val  Asn Ala Val 
    1250                 1255                 1260             


Arg Ser  Leu Met Ser Tyr Asp  Arg Lys Leu Lys Asn  Ala Val Pro 
    1265                 1270                 1275             


Lys Ser  Ile Lys Arg Ile Leu  Gly Glu Glu Gly Leu  Ile Ile Glu 
    1280                 1285                 1290             


Trp Gln  Met Lys Asp Asp Arg  Leu Lys Lys Pro Thr  Ile Tyr Pro 
    1295                 1300                 1305             


Asp Val  Glu Thr His Leu Thr  Met Val Pro Pro His  Met Met Ser 
    1310                 1315                 1320             


Ala Pro  Val Ser Phe Thr Leu  Pro Arg Ala Ser Val  Arg Leu Val 
    1325                 1330                 1335             


Ser Met  Thr Arg Ala Met Phe  Asp Phe Gly Gly Ser  Gly Tyr Gly 
    1340                 1345                 1350             


Asp Glu  Val Val Leu Ala Gly  Lys Thr Val Lys Gln  Ala Val Tyr 
    1355                 1360                 1365             


Pro Asp  Ala Phe Thr Ala Arg  Phe Pro Gln Thr Pro  Glu Thr Leu 
    1370                 1375                 1380             


Lys Lys  Glu Thr Arg Leu Val  Phe Thr Ser Glu Lys  Glu Gln Ile 
    1385                 1390                 1395             


Ser Asp  
    1400 


<210>  200
<211>  1257
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  200

Met Lys Ile Val His Pro Tyr Gly Ser Ser Arg Ser Gln Ser Asp Ala 
1               5                   10                  15      


Lys Ala Ser Arg Arg Val Leu Ile Asp Asn Thr Arg Glu Arg Arg Pro 
            20                  25                  30          


His Pro Ile Pro Arg Phe Ala Gly Val His Asp Leu Ala Ala Ala Ala 
        35                  40                  45              


Glu Gly Ala Asn Asp Glu Leu Val Ile Ala Gln Trp Ile Ser Ile Val 
    50                  55                  60                  


Asp Lys Ile Ala Arg Lys Pro Ser Gly Arg Asn Lys Pro Thr Arg Glu 
65                  70                  75                  80  


Gln Arg Asp Leu Arg Glu Lys Leu Gly Asn Ala Cys Trp Val Arg Met 
                85                  90                  95      


Thr Cys Gly Asn His Leu Pro Gly Leu Asp Lys Arg Arg Glu His Leu 
            100                 105                 110         


Asn Lys Leu Trp Trp Phe Lys Ile His Pro Tyr Gly Pro Gly Thr Glu 
        115                 120                 125             


Glu Pro Arg Arg Arg Lys Asp Gly Ser Leu Pro Ala Ser Ala Glu Ala 
    130                 135                 140                 


Lys Gly Arg Trp Tyr Glu Val Phe Ala Gly Asp Ser Ala Arg Asp Pro 
145                 150                 155                 160 


Ala Asp Ala Arg Thr Leu Ala Glu Ile Val Ala Glu Arg Ile Glu Arg 
                165                 170                 175     


His Leu Tyr Val Gln Lys Tyr Arg Leu Gly Pro Asp Ser Arg Pro Lys 
            180                 185                 190         


Glu Met Gly Leu Ile Ala Ala Arg Ala Tyr Ser Ile Glu Gly Asn Val 
        195                 200                 205             


Leu Arg Val Pro Glu Gly Ser Asp Thr Gly Asp Asp Arg Pro Thr Trp 
    210                 215                 220                 


Ser Asp Glu Asp Ile Asn Val Tyr Thr Gln Pro Gly Asp Pro Val Arg 
225                 230                 235                 240 


Ala Ile Arg Ala Ala Ala Glu Ala Leu Glu Ala Gln Lys Gly Arg Leu 
                245                 250                 255     


Arg Leu Ser Asp Ala Ala Lys Met Leu Phe Glu His Trp Pro Lys Val 
            260                 265                 270         


Phe Arg Asn Ala Glu Gly Lys Val Leu Asp Val Pro Gly Ala Arg Gln 
        275                 280                 285             


Gln Tyr Pro Gly Met Phe Ala Leu His Asp Gln Leu Lys Gln Cys Tyr 
    290                 295                 300                 


Arg Arg Leu Leu Lys Arg Ala Arg Lys Asp Thr Pro Glu His Arg Arg 
305                 310                 315                 320 


Asp Ala Ala Ala Arg Lys Arg Glu Glu Arg Lys Leu Ser Thr Leu Leu 
                325                 330                 335     


Pro Arg Asp Leu Lys Ala Ala Leu Arg Leu Ser Asp Met Gln Thr Arg 
            340                 345                 350         


Asn Ala Glu Leu Ala Ala Leu Val Arg Leu Gly Lys Val Ile His Tyr 
        355                 360                 365             


Thr Ala Ala Gln Gly Ile Ala Asp Gln Thr Arg Ala Val Ile Asp Asn 
    370                 375                 380                 


Trp Pro Asp Asp Val Glu Ala Ser Arg Phe Trp Gln Ser Asp Gly Gln 
385                 390                 395                 400 


Ala Glu Ile Lys Arg Ala Glu Ala Phe Val Arg Ile Trp Arg Gln Ala 
                405                 410                 415     


Leu Val Leu Ala Asn Leu Thr Leu Arg Asp Trp Ala Asp Tyr Arg Gly 
            420                 425                 430         


Asp Ile Leu Gly Thr Glu Gly Gln Lys Gln Glu Ala Leu Ala Asn Ala 
        435                 440                 445             


Thr Ala Ala Leu Arg Ser Ser Asp Pro Ala Arg Arg Asp Arg Phe Asp 
    450                 455                 460                 


Arg Lys Leu Val Leu Leu Phe Gly Asn Arg Ala Thr Val Leu Gly Leu 
465                 470                 475                 480 


Ala Thr Asp Glu Asp Arg Ile Ala Leu Leu Arg Ala Leu Ile Asp Gly 
                485                 490                 495     


Ala Ala Asn Leu Arg His Ala Ser Phe His Phe Lys Gly Arg Gly Glu 
            500                 505                 510         


Leu Leu Val Glu Leu Glu Lys Leu Pro Asp Asn Phe Ser Glu Pro Val 
        515                 520                 525             


Lys Ala Ala Ala Gly Ala Leu Trp Gln Ala Asp Val Lys Asp Arg Thr 
    530                 535                 540                 


Ala Arg Leu Lys Ala Val Leu Val Gly Ala His Ala Asp Lys Tyr Leu 
545                 550                 555                 560 


Thr Gln Lys Gln Ala Glu Gln Val Phe Ala Leu Leu His Ala Asn Ala 
                565                 570                 575     


Ala Glu Leu Pro Leu Pro Arg Phe Ala Arg Val Leu Glu Arg Arg Lys 
            580                 585                 590         


Asn Ala Trp Asp Glu Asp Lys Gly Ile Arg Leu Pro Glu Pro Pro Asn 
        595                 600                 605             


Arg Arg Lys Leu Glu Glu Gln Lys Ala Arg Leu Cys Leu Tyr Thr Leu 
    610                 615                 620                 


Leu Thr Leu Val Tyr Glu Arg Pro Phe Arg Thr Trp Leu Thr Glu Gln 
625                 630                 635                 640 


Gln Thr Ala Ala Ile Ala Arg Trp Arg Asp Arg Ala Val Asn Arg Ala 
                645                 650                 655     


Ser Ala Ala Ala Lys Ala Gln Asn Ala Lys Asp Asp Glu Ile Ala Arg 
            660                 665                 670         


Gln Val Ile Ala Ala Arg Ala Ala Asp Leu Pro Val Leu Pro Glu Gly 
        675                 680                 685             


Gly Asp Ile Arg His Phe Phe Phe Asp Leu Ser Ala Ala Thr Ala Ser 
    690                 695                 700                 


Glu Met Arg Val Gln Arg Gly Tyr Ala Ser Asp Ala Glu Asn Ala Arg 
705                 710                 715                 720 


Asn Gln Ala Gly Phe Ile Asp Asp Leu Leu Cys Asp Val Met Ile Leu 
                725                 730                 735     


Ala Phe Ser Ala Tyr Leu Glu Glu Lys Ala Leu Gly Trp Leu Leu Asp 
            740                 745                 750         


Ile Arg Pro Asp Gln Pro Pro Ser Glu Ser Pro Thr Cys Ser Leu Lys 
        755                 760                 765             


Ala Leu Pro Glu Pro Lys Pro Asp Leu Ala Pro Gln Arg Trp Gln Thr 
    770                 775                 780                 


Ala Leu Tyr Leu Ile Leu His Val Leu Pro Val Glu Ser Val Gly Gln 
785                 790                 795                 800 


Leu Leu His Gln Leu Arg Arg Trp Gly Ile Ala Ala Gly Arg Asp Ser 
                805                 810                 815     


Arg Leu Arg Glu Asp Glu Arg Ala Arg Leu Asp Arg Leu Phe Ala Ala 
            820                 825                 830         


Met Thr Leu Tyr Leu Asp Met His Asp Ala Lys Phe Glu Gly Gly Asp 
        835                 840                 845             


Ala Leu Ala Gly Cys Gly Pro Leu Cys Glu Leu Phe Ala Ser Lys Glu 
    850                 855                 860                 


Asp Gly Phe Arg Arg Val Phe Arg Asp Pro Glu Pro Gly Ala Gln Leu 
865                 870                 875                 880 


Asp Arg Arg Val Pro His Arg Gly Leu Arg Glu Ile Met Arg Phe Gly 
                885                 890                 895     


His Leu Pro Val Leu Asn Ala Ile Arg Gly Gly Lys Thr Ile Asp Asp 
            900                 905                 910         


Lys Thr Ile Asp Arg Val Leu Ala Met Glu Ala Ala Pro Asp Asp Gly 
        915                 920                 925             


Arg Ser Pro Ile Ala Lys Leu Gln Gln Arg Arg Glu Asp Leu His Glu 
    930                 935                 940                 


Ala Trp Val Gln Ser Lys Glu Pro Asp Ala Ala Arg Pro Phe Gly Gln 
945                 950                 955                 960 


Ser Glu Leu Glu Asp Tyr Cys Lys Thr Leu Ala Asp Val Val Arg His 
                965                 970                 975     


Arg Ala Glu Ser Asn Val Val Tyr Leu Val Asp His Val Arg Ala His 
            980                 985                 990         


Arg Thr Val Met Ala Val Leu Gly  Arg Leu Val Asp Tyr  Ala Gly Leu 
        995                 1000                 1005             


Phe Glu  Arg Asp Leu Tyr Phe  Val Thr Leu Ala Leu  Leu His Arg 
    1010                 1015                 1020             


His Gly  Leu Arg Pro Asp Asp  Leu Ser Thr Ser Thr  Gly Val Asn 
    1025                 1030                 1035             


His Leu  Gly Lys Gly Arg Ile  Ile Ser Ala Leu Tyr  Gln His Lys 
    1040                 1045                 1050             


Lys Asp  Asp Thr Ala Leu Ala  Val Leu Arg Asp Leu  Ala Ala His 
    1055                 1060                 1065             


Phe Thr  Lys Val Trp Glu Ser  Gly Asn Pro Lys Val  Arg Ile Arg 
    1070                 1075                 1080             


Asn Asp  Leu Met His Phe Asn  Met Leu Gln Lys Ala  Pro Pro Ala 
    1085                 1090                 1095             


Pro His  Leu Thr His Trp Val  Asn Gln Ala Arg Gln  Leu Met Asp 
    1100                 1105                 1110             


Tyr Asp  Arg Lys Leu Lys Asn  Ala Val Ser Lys Ser  Val Ile Glu 
    1115                 1120                 1125             


Leu Leu  Ala Arg Glu Gly Ile  Val Leu Arg Trp Asp  Ile Asn Ala 
    1130                 1135                 1140             


Thr Ala  Ala Ser His Asp Leu  Val Asn Ala Asp Leu  Ser Ser Arg 
    1145                 1150                 1155             


Cys Ala  Val His Leu Gly Gly  Gln Ala Leu Arg Arg  Lys Gly Ala 
    1160                 1165                 1170             


Asp Arg  Arg Asp Lys Gly Ala  Pro Ile Ala Glu Arg  Leu His Gly 
    1175                 1180                 1185             


Glu Asn  Tyr Val Val Met Ile  Ala Asn Ala Phe Glu  Gly Thr Ala 
    1190                 1195                 1200             


Lys Glu  Thr Thr Thr Ile Leu  Asp Asp Leu Leu Gln  Val Asp Trp 
    1205                 1210                 1215             


Ala Ala  Ser Val Ala Pro Arg  Gly Arg Pro Lys Glu  Val Gly Ala 
    1220                 1225                 1230             


Gln Arg  Pro Pro Ser Asp Arg  Gln Arg Ala Arg Arg  Gly Asn His 
    1235                 1240                 1245             


Asp Ser  Arg Arg Asn Leu Ala  Ser Asn 
    1250                 1255         


<210>  201
<211>  1182
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  201

Met Lys Gly Gly Ser Met Lys Ile Thr Lys Val Asp Gly Leu Ser His 
1               5                   10                  15      


Tyr Lys Lys Gln Asp Lys Gly Ile Leu Lys Lys Lys Trp Arg Asp Leu 
            20                  25                  30          


Asp Glu Arg Lys Gln Arg Glu Lys Ile Glu Glu Arg Tyr Asn Lys Gln 
        35                  40                  45              


Ile Glu Ser Lys Ile Tyr Lys Glu Phe Phe Arg Leu Lys Asn Lys Lys 
    50                  55                  60                  


Arg Ile Glu Lys Glu Glu Asp Gln Asn Ile Lys Ser Leu Tyr Phe Phe 
65                  70                  75                  80  


Ile Lys Glu Met Tyr Leu Asn Glu Glu Asn Glu Glu Trp Glu Leu Lys 
                85                  90                  95      


Asn Ile Asn Leu Glu Ile Leu Asp Asp Lys Glu Arg Val Ile Lys Gly 
            100                 105                 110         


Tyr Lys Phe Lys Glu Asp Val Tyr Phe Phe Lys Glu Gly Asp Lys Lys 
        115                 120                 125             


Tyr Tyr Leu Arg Thr Leu Leu Asn Asn Leu Ile Glu Lys Ile Gln Asn 
    130                 135                 140                 


Glu Asn Arg Asp Lys Val Arg Lys Asn Lys Glu Phe Ser Asp Leu Lys 
145                 150                 155                 160 


Glu Ile Phe Lys Lys Tyr Lys Asp Arg Lys Ile Lys Leu Leu Leu Glu 
                165                 170                 175     


Ser Ile Asn Asn Asn Lys Ile Asn Leu Glu Tyr Lys Lys Glu Asn Val 
            180                 185                 190         


Asn Glu Glu Ile Tyr Gly Ile Asn Pro Thr Asn Asp Arg Glu Met Thr 
        195                 200                 205             


Phe His Glu Leu Leu Lys Glu Ile Ile Glu Lys Lys Asp Glu Gln Lys 
    210                 215                 220                 


Ser Ile Leu Glu Glu Lys Leu Asp Asn Phe Asp Ile Thr Asn Phe Leu 
225                 230                 235                 240 


Glu Asn Ile Glu Lys Ile Phe Asn Glu Glu Thr Glu Ile Asn Ile Ile 
                245                 250                 255     


Lys Gly Lys Val Leu Asn Glu Leu Arg Glu Tyr Ile Arg Glu Lys Glu 
            260                 265                 270         


Glu Asn Asn Ser Asp Tyr Lys Leu Lys Gln Ile Tyr Asn Leu Glu Leu 
        275                 280                 285             


Lys Lys Tyr Ile Glu Asn Asn Phe Ser Tyr Lys Lys Gln Lys Ser Lys 
    290                 295                 300                 


Ser Lys Asn Gly Lys Asn Asp Tyr Leu Tyr Leu Asn Phe Leu Lys Lys 
305                 310                 315                 320 


Ile Met Phe Ile Glu Glu Val Asp Glu Lys Lys Gly Ile Asn Lys Glu 
                325                 330                 335     


Lys Phe Lys Asn Lys Ile Asn Ser Asn Phe Lys Asn Leu Phe Val Gln 
            340                 345                 350         


His Ile Leu Asp Tyr Gly Lys Leu Leu Tyr Tyr Lys Glu Asn Asp Glu 
        355                 360                 365             


Tyr Ile Lys Asn Thr Gly Gln Leu Glu Thr Lys Asp Leu Glu Tyr Ile 
    370                 375                 380                 


Lys Thr Lys Glu Thr Leu Ile Arg Lys Met Ala Val Leu Val Ser Phe 
385                 390                 395                 400 


Ala Ala Asn Ser Tyr Tyr Asn Leu Phe Gly Arg Thr Glu Asn Asn Ile 
                405                 410                 415     


Leu Thr Gln Glu Ile Ser Asp Asp Leu Leu Leu Gly Lys Ile Glu Asn 
            420                 425                 430         


Glu Ile Tyr Ile Lys Gly Glu Lys Asn Arg Arg Tyr Val Phe Lys Glu 
        435                 440                 445             


Lys Met Leu Asn Tyr Phe Phe Asn Pro Glu Ile Phe Gly Asp Asn Lys 
    450                 455                 460                 


Ile Val Glu Val Leu Ser Ala Ile Ser Ser Ser Ile Tyr Asn Ile Arg 
465                 470                 475                 480 


Asn Gly Val Asn His Phe Asp Lys Ile Asn Leu Gly Gln Tyr Asn Asn 
                485                 490                 495     


Leu Asp Leu Ser Glu Ile Lys Lys Tyr Phe Ile Glu Lys Arg Asp Lys 
            500                 505                 510         


Ile Lys Glu Lys Val Lys Glu Lys Phe Ser Ser Asn Asn Leu Gln Tyr 
        515                 520                 525             


Tyr Tyr Ala Lys Lys Glu Ile Glu Asn Tyr Phe Lys Ala Tyr Glu Phe 
    530                 535                 540                 


Glu Ile Leu Lys Glu Lys Ile Pro Phe Ala Pro Asn Phe Lys Arg Ile 
545                 550                 555                 560 


Ile Lys Lys Gly Glu Asp Leu Phe Asn Asn Lys Lys Asn Lys Lys Tyr 
                565                 570                 575     


Glu Tyr Phe Lys Asn Phe Asp Lys Asn Ile Ala Glu Glu Lys Lys Glu 
            580                 585                 590         


Phe Leu Lys Thr Arg Asn Phe Leu Leu Lys Glu Leu Tyr Tyr Asn Asn 
        595                 600                 605             


Phe Tyr Lys Glu Phe Leu Ser Lys Lys Glu Glu Phe Lys Lys Val Val 
    610                 615                 620                 


Ile Glu Val Lys Glu Glu Lys Lys Asn Arg Gly Asn Ile Asn Asn Lys 
625                 630                 635                 640 


Lys Ser Gly Val Ser Phe Gln Ser Ile Asp Asp Tyr Asp Thr Lys Ile 
                645                 650                 655     


Asn Ile Ser Asp Tyr Ile Ala Ser Ile His Lys Lys Glu Met Glu Arg 
            660                 665                 670         


Val Glu Lys Tyr Asn Glu Glu Lys Gln Lys Asp Thr Ala Lys Tyr Ile 
        675                 680                 685             


Arg Asp Phe Val Glu Glu Ile Phe Leu Thr Gly Phe Ile Asn Tyr Leu 
    690                 695                 700                 


Glu Lys Asp Lys Arg Leu His Phe Leu Lys Glu Glu Phe Ser Ile Leu 
705                 710                 715                 720 


Cys Asn Asn Asn Asn Asn Val Val Asp Phe Asn Ile Asn Ile Asn Glu 
                725                 730                 735     


Glu Lys Ile Lys Glu Phe Leu Lys Glu Asn Asp Ser Lys Thr Leu Asn 
            740                 745                 750         


Leu Tyr Leu Phe Phe Asn Met Ile Asp Ser Lys Arg Ile Ser Glu Phe 
        755                 760                 765             


Arg Asn Glu Leu Ile Lys Tyr Lys Gln Phe Thr Lys Arg Arg Leu Asp 
    770                 775                 780                 


Glu Lys Lys Glu Phe Leu Gly Ile Glu Ile Glu Leu Tyr Glu Thr Leu 
785                 790                 795                 800 


Ile Glu Phe Val Ile Leu Thr Arg Glu Lys Leu Asp Thr Lys Lys Ser 
                805                 810                 815     


Glu Glu Ile Asp Ala Trp Leu Val Asp Lys Leu Tyr Val Lys Asp Asn 
            820                 825                 830         


Asn Glu Tyr Lys Glu Tyr Glu Glu Ile Leu Lys Leu Phe Val Asp Glu 
        835                 840                 845             


Lys Ile Leu Ser Ser Lys Glu Ala Pro Tyr Tyr Ala Thr Asp Asn Lys 
    850                 855                 860                 


Thr Pro Ile Leu Leu Ser Asn Phe Glu Lys Thr Arg Lys Tyr Gly Thr 
865                 870                 875                 880 


Gln Ser Phe Leu Ser Glu Ile Gln Ser Asn Tyr Lys Tyr Ser Lys Val 
                885                 890                 895     


Glu Lys Glu Asn Ile Glu Asp Tyr Asn Lys Lys Glu Glu Ile Glu Gln 
            900                 905                 910         


Lys Lys Lys Ser Asn Ile Glu Lys Leu Gln Asp Leu Lys Val Glu Leu 
        915                 920                 925             


His Lys Lys Trp Glu Gln Asn Lys Ile Thr Glu Arg Glu Ile Lys Lys 
    930                 935                 940                 


Tyr Asn Asp Thr Ile Lys Glu Ile Arg Glu Tyr Asn Tyr Leu Lys Asn 
945                 950                 955                 960 


Lys Glu Glu Leu Gln Asn Val Tyr Leu Leu His Glu Met Leu Ser Asp 
                965                 970                 975     


Leu Leu Ala Arg Asn Val Ala Phe Phe Asn Lys Trp Glu Arg Asp Phe 
            980                 985                 990         


Lys Phe Ile Val Ile Ala Ile Lys  Gln Phe Leu Arg Glu  Asn Asp Lys 
        995                 1000                 1005             


Glu Lys  Val Asn Glu Phe Leu  Asn Pro His Lys Ser  Asp Gly Ser 
    1010                 1015                 1020             


Arg Asp  Asn Phe Ser Val Thr  Asn Tyr Arg Ser Lys  Met Lys Ser 
    1025                 1030                 1035             


Ile Ile  Asn Asn Ile His Glu  Asn Phe Met Ser Leu  Leu Phe Leu 
    1040                 1045                 1050             


Asn Asn  Asn Leu Ala Thr Gly  Gly Ile Gln Met Gly  Arg Asn Asn 
    1055                 1060                 1065             


Asn Phe  Thr Trp Gly Asn Leu  Arg Asn Tyr Ile Ala  His Phe Glu 
    1070                 1075                 1080             


Tyr Leu  His Lys Glu Lys Asp  Thr Ile Ser Phe Leu  Asn Gln Ala 
    1085                 1090                 1095             


Asn Leu  Leu Ile Lys Leu Phe  Ser Tyr Asp Lys Lys  Val Gln Asn 
    1100                 1105                 1110             


His Ile  Ile Lys Ser Met Lys  Thr Leu Leu Glu Lys  Tyr Asn Ile 
    1115                 1120                 1125             


Glu Ile  Gly Phe Glu Ile Ser  Asn Asp Ser Glu Glu  Ile Phe Glu 
    1130                 1135                 1140             


Tyr Lys  Ile Lys Tyr Ile Asn  Ser Lys Lys Gly Lys  Met Leu Gly 
    1145                 1150                 1155             


Lys Asn  Asn Glu Phe Glu Ile  Leu Glu Asn Glu Phe  Val Arg Asn 
    1160                 1165                 1170             


Val Lys  Ala Leu Leu Glu Tyr  Ser Lys 
    1175                 1180         


<210>  202
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  202

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Asn Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys His Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Asn Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Glu 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Val Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Thr Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Lys Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Glu  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  203
<211>  1316
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  203

Leu Thr Arg Leu Pro Ser Glu Ala Gly Pro Thr Gln Asp Phe Gly Val 
1               5                   10                  15      


Cys Asn Gln Ala Val Phe Ala Phe Leu Arg Val Leu Pro Leu Thr Cys 
            20                  25                  30          


Gly Gly Ser Pro Ser Cys Arg Arg Val Val Glu Arg His Phe Ala Arg 
        35                  40                  45              


Gly Phe Ile Asn His Arg Pro His Val Lys Leu Pro Ala Ile Phe Arg 
    50                  55                  60                  


Gly Val Ala Ser Met Arg Ile Val Arg Pro Tyr Gly Ser Ser Arg Ser 
65                  70                  75                  80  


Arg Lys Ser Gly Glu Glu Val Arg Arg Val Leu Val Asp Ser Thr Ala 
                85                  90                  95      


Glu Arg Thr Glu Trp Asp Ile Pro Pro Phe Ala Arg Ser His Asp Lys 
            100                 105                 110         


Leu Val Ile Ala Gln Trp Ile Ser Thr Ile Asp Lys Ile Ala Cys Lys 
        115                 120                 125             


Pro Ala Gly Arg Lys Lys Pro Thr Pro Ala Gln Tyr Ala Leu Arg Glu 
    130                 135                 140                 


Lys Leu Gly Asn Val Cys Trp Leu Arg Met Thr Glu Gly Gly His Leu 
145                 150                 155                 160 


Pro Gly Ala Ala Gly Ala Asp Arg Glu His Leu Asn Asn Ile Trp Trp 
                165                 170                 175     


Phe Lys Ile His Pro Tyr Gly Thr Glu Thr Glu Glu Pro Arg Pro Arg 
            180                 185                 190         


Arg Asp Gly Ser Leu Pro Pro Ser Ala Glu Leu Lys Gly Arg Trp Phe 
        195                 200                 205             


Glu Ala Phe Ala Gly Thr Trp Asp Pro Glu Lys Thr Ser Ala Arg Glu 
    210                 215                 220                 


Thr Val Asp Ile Leu Ala Gln Ile Ala Glu Arg Ile Glu Lys His Leu 
225                 230                 235                 240 


Tyr Glu Thr Glu Tyr Arg Leu Gly Gln Asn Lys Arg Pro Lys Arg Leu 
                245                 250                 255     


Gly Arg Ile Glu Ala Arg Ala Glu Ser Ile Glu Gly Asn Val Leu His 
            260                 265                 270         


Val Pro Ile Ala Ser Glu Asp Gln Arg Asn Gln Pro Thr Trp Thr Glu 
        275                 280                 285             


Asp Asp Lys Gln Ala Tyr Thr Arg Asn Arg Asp Pro Ile His Ala Ile 
    290                 295                 300                 


Arg Gln Ala Ala Glu Lys Leu Glu Ser Asn Lys Gly Arg Ile Ser Leu 
305                 310                 315                 320 


Ser Asp Ala Ala Glu Val Leu Phe Gly His Trp Ala Lys Ile Phe Val 
                325                 330                 335     


Tyr His Glu Thr Gly Lys Pro Met Gly Val Arg Asp Ala Ser Glu Arg 
            340                 345                 350         


His Pro Gly Met Phe Ala Leu His Gln Thr Leu Lys Glu Cys Tyr Arg 
        355                 360                 365             


Arg Leu Leu Lys Arg Thr Arg Lys Asp Thr Arg His His Arg Lys Glu 
    370                 375                 380                 


Asn Pro Asp Gly Arg Arg Leu Ser Ala Leu Leu Pro Arg Asn Leu Asp 
385                 390                 395                 400 


Asp Ala Leu Arg Leu Met Arg Met Gln Ala Ala Asn Ala Glu Leu Ala 
                405                 410                 415     


Glu Leu Val Arg Leu Gly Lys Ile Ile His Tyr Ala Ala Ser Glu Gly 
            420                 425                 430         


Arg Ala Asp Arg Ala Lys Ser Ile Arg Glu His Trp Pro Gln Asn Val 
        435                 440                 445             


Ala Gln Ser Arg Phe Trp Gln Ser Asp Gly Gln Ala Glu Ile Lys Arg 
    450                 455                 460                 


Ala Glu Ala Phe Val Arg Val Trp Arg Gln Val Leu Ala Leu Ala Gly 
465                 470                 475                 480 


Leu Thr Leu Lys Asp Trp Leu Ser Phe Pro Gly Asp Leu Leu Gly Gly 
                485                 490                 495     


Asp Arg Thr Lys Asn Ala Ala Ile Lys Asn Ala Ile Glu Ala Leu Arg 
            500                 505                 510         


Thr Asp Ala Ser Lys His Glu Arg Phe Asp Arg Lys Leu Asn Val Leu 
        515                 520                 525             


Phe Gly Glu Arg Thr Asp Leu Leu Gly Val Gly Ser Ala Asp Asp Arg 
    530                 535                 540                 


Val Asp Leu Leu Cys Ala Leu Val Asp Gly Ala Ala Asn Leu Arg His 
545                 550                 555                 560 


Ala Ile Phe His Phe Lys Gly Arg Gly Gln Leu Leu Asp Glu Leu Ala 
                565                 570                 575     


Arg Leu Pro Ala His Leu Ser Ala Pro Val Lys Gln Ala Ser Glu Arg 
            580                 585                 590         


Leu Trp Glu Lys Asp Val Thr Glu Cys Thr Ala Arg Leu Lys Lys Thr 
        595                 600                 605             


Leu Val Gly Ala His Val Glu Glu Phe Ile Thr Gln Glu Gln Ala Met 
    610                 615                 620                 


Gln Val Phe Val Leu Val Ala Asp Asn Thr Leu Ala Glu Leu Pro Leu 
625                 630                 635                 640 


Pro Arg Phe Ala Arg Ile Leu Glu Arg Arg Lys Asn Ala Trp Glu Glu 
                645                 650                 655     


Thr Ile Arg Leu Pro Glu Pro Ala Asn Leu Arg Ala Leu Glu Asp Ser 
            660                 665                 670         


Ala Arg Leu Cys Gln Tyr Thr Leu Leu Lys Leu Val Tyr Glu Arg Pro 
        675                 680                 685             


Phe Arg Ala Trp Leu Thr Lys Gln Asp Ala Gln Ala Ile Ser Asn Trp 
    690                 695                 700                 


Ile Asp Arg Ala Val Ala Arg Ala Thr Glu Ala Ala Lys Ala Leu Asn 
705                 710                 715                 720 


Ala Gln Gly Ser Glu Ala Gly Arg Lys Val Ile Ala Ala Arg Ala Ala 
                725                 730                 735     


Asp Leu Pro Lys Pro Ser Val Gly Gly Asp Ile Thr Glu Phe Phe Phe 
            740                 745                 750         


Ala Leu Ser Ala Ala Thr Ala Ser Glu Met Arg Val Gln Ser Gly Tyr 
        755                 760                 765             


Glu Thr Asp Arg Glu Lys Ala Arg Glu Gln Ala Glu Tyr Ile Asn Asp 
    770                 775                 780                 


Leu Leu Cys Asp Val Thr Ile Leu Ala Phe Asp Ala Tyr Thr Ala Gln 
785                 790                 795                 800 


Ala Lys Leu Gly Trp Leu Leu Asp Ile Ala Arg Asp Arg Pro Ala Thr 
                805                 810                 815     


Cys Leu Ile Ala Glu Leu Pro Asp Pro Gln Arg Asp Leu Ala Ala Glu 
            820                 825                 830         


Pro Trp Gln Ser Ala Leu Tyr Leu Ile Leu His Val Leu Pro Val Glu 
        835                 840                 845             


Ser Val Gly Gln Leu Leu His Gln Leu Leu Arg Trp Lys Thr Ala Ala 
    850                 855                 860                 


Gly Arg Asp Val Glu Trp Ser Glu Lys Asp Gln Ala Arg Leu Gln Arg 
865                 870                 875                 880 


Leu Leu Ala Thr Met Thr Leu Tyr Leu Asp Met His Asp Ala Lys Phe 
                885                 890                 895     


Glu Gly Gly Ser Ala Leu Ala Gly Cys Glu Glu Phe Ala Gly Leu Phe 
            900                 905                 910         


Glu Ser Glu Ala Gly Phe Arg Lys Val Phe Pro Ala Val Leu Asp Glu 
        915                 920                 925             


Asn Ala Glu Leu Arg Ile Pro Arg Arg Gly Leu Arg Glu Ile Val Arg 
    930                 935                 940                 


Phe Gly His Leu Pro Leu Leu Lys Ala Ile Cys Gly Val Lys Lys Ile 
945                 950                 955                 960 


Asp Glu Asp Thr Ile Asp Arg Val Phe Ser Ile Glu Gly Val Leu Glu 
                965                 970                 975     


Gly Gly Glu Ser Gln Ile Ala Gln Met Gln Lys Arg Arg Glu Glu Leu 
            980                 985                 990         


His Asp Ala Trp Ile Val Thr Lys  Arg Gly Pro Ala Ile  Glu Lys Asp 
        995                 1000                 1005             


Ala Asp  Gly Glu Ala Met Lys  Arg Phe Gly Ala Glu  Glu Leu His 
    1010                 1015                 1020             


Glu Tyr  Cys Glu Ile Leu Thr  Asn Val Ser Arg His  Arg Glu Gln 
    1025                 1030                 1035             


Ser Asn  Phe Val Asn Leu Val  Asp His Val Arg Ala  Tyr Arg Leu 
    1040                 1045                 1050             


Val Leu  Ala Val Phe Gly Arg  Leu Val Asp Tyr Val  Gly Leu Phe 
    1055                 1060                 1065             


Glu Arg  Asp Leu Tyr Phe Val  Thr Leu Ala Leu Leu  His Gln Arg 
    1070                 1075                 1080             


Gly Leu  Arg Ala Glu Asp Leu  Leu Glu Gln Gly Gly  Leu Glu His 
    1085                 1090                 1095             


Leu Tyr  Gly Gly Arg Ile Ile  Phe Ala Leu Asp Arg  Arg Arg Thr 
    1100                 1105                 1110             


Asp Thr  Pro Lys Ala Ala Glu  Ile Ser Met Glu Leu  Ala Lys His 
    1115                 1120                 1125             


Phe Thr  Glu Leu Trp Thr Lys  Gly Asn Pro Asn Arg  Arg Ile Arg 
    1130                 1135                 1140             


Asn Asp  Leu Ala His Leu Asn  Thr Leu Gln Gly Thr  Gly Phe Ala 
    1145                 1150                 1155             


Pro Arg  Leu Thr His Trp Val  Asn Gln Thr Arg Gln  Leu Met Ala 
    1160                 1165                 1170             


Tyr Asp  Arg Lys Leu Lys Asn  Ala Ile Ser Lys Ser  Val Leu Asp 
    1175                 1180                 1185             


Leu Leu  Asp Arg Glu Gly Ile  Lys Leu Arg Trp Thr  Met Asp Val 
    1190                 1195                 1200             


Ser Asp  Asn Thr His Asp Leu  Thr Asn Ala Thr Leu  Ala Thr Arg 
    1205                 1210                 1215             


Cys Ala  Glu His Leu Gly Asn  Lys Lys Leu Thr Leu  Lys Gly Ala 
    1220                 1225                 1230             


Gly Pro  Lys Asp Arg Glu Val  Pro Ile Asn Glu Arg  Leu His Ser 
    1235                 1240                 1245             


Glu Ser  Tyr Val Ala Met Val  Ala Ser Ala Phe Glu  Gly Thr Pro 
    1250                 1255                 1260             


Ile Ala  Thr Arg Ser Ile Leu  Asp Asp Leu Ser Arg  Val Ala Trp 
    1265                 1270                 1275             


Glu Ala  Ser Val Ala Pro Arg  Arg Leu Pro Arg Asp  Pro Arg Gln 
    1280                 1285                 1290             


Gly Pro  Pro Arg Lys Pro Phe  Pro Gly Gly Arg Asn  Arg Arg Asp 
    1295                 1300                 1305             


Phe Ser  Gly Thr Ser His His  Thr 
    1310                 1315     


<210>  204
<211>  1389
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  204

Met Gly Asn Leu Phe Gly His Lys Arg Trp Tyr Glu Val Arg Asp Lys 
1               5                   10                  15      


Glu Asp Tyr Lys Ile Arg Arg Lys Val Lys Val Lys Arg Asn Tyr Asp 
            20                  25                  30          


Gly Asn Lys Tyr Ile Leu Asn Ile Asn Glu Asn Asn Asn Lys Glu Lys 
        35                  40                  45              


Ile Asp Asn Asn Lys Phe Ile Arg Glu Phe Val Asn Tyr Lys Lys Asn 
    50                  55                  60                  


Asp Asn Val Leu Arg Glu Phe Lys Arg Lys Phe His Ala Gly Asn Ile 
65                  70                  75                  80  


Leu Phe Lys Leu Lys Gly Asn Lys Arg Ser Ile Glu Asp Ser Asn Asp 
                85                  90                  95      


Phe Leu Lys Thr Glu Glu Val Val Leu Asp Lys Glu Ile Tyr Gly Gln 
            100                 105                 110         


Ser Glu Lys Leu Arg Asn Glu Lys Gly Ile Thr Lys Lys Asp Ile Leu 
        115                 120                 125             


Lys Glu Ile Asn Lys Gln Lys Ile Asp Asn Ser Val Lys Lys Ile Ser 
    130                 135                 140                 


Met Asn Thr Asn Ser Gly Lys Thr Ile Val Ile Asn Phe Ser Asp Lys 
145                 150                 155                 160 


Leu Lys Lys Asp Lys Asp Asp Tyr Gln Ile Thr Leu Asn Ile Ile Ser 
                165                 170                 175     


Glu Asp Glu Leu Glu Arg Lys Arg Lys Ile Tyr Asp Ile Phe Lys Met 
            180                 185                 190         


Ile Asn Met Asp Leu Tyr Gln Ile Ile Lys Glu Ile Ile Glu Asn Glu 
        195                 200                 205             


Val Gln Lys Val Phe Lys Asn Arg Tyr Tyr Glu Glu His Leu Arg Glu 
    210                 215                 220                 


Lys Leu Leu Lys Asp Asp Glu Ile Asp Val Ile Leu Thr Asn Phe Met 
225                 230                 235                 240 


Lys Ile Arg Glu Lys Ile Glu Ser Asn Pro Glu Ile Met Gly Phe Val 
                245                 250                 255     


Lys Phe Tyr Leu Asn Val Gly Gly Asp Lys Lys Lys Ser Glu Asn Lys 
            260                 265                 270         


Lys Met Phe Val Glu Lys Ile Leu Asn Ile Asn Val Asp Leu Thr Glu 
        275                 280                 285             


Glu Asp Ile Val Asp Phe Ile Val Lys Glu Leu Lys Phe Trp Asn Ile 
    290                 295                 300                 


Thr Lys Arg Ile Glu Lys Val Lys Glu Phe Asn Asn Lys Ser Leu Glu 
305                 310                 315                 320 


Asn Lys Arg Asn Arg Thr Tyr Ile Lys Ser Tyr Val Leu Leu Asp Lys 
                325                 330                 335     


His Glu Lys Phe Lys Arg Asp Arg Glu Asn Lys Lys Asp Lys Ile Val 
            340                 345                 350         


Lys Leu Phe Val Lys Asp Ile His Asn Asp Lys Met Glu Glu Lys Ile 
        355                 360                 365             


Asn His Ile Leu Ser Glu Phe Lys Ile Lys Glu Leu Ile Glu Lys Leu 
    370                 375                 380                 


Lys Glu Asn Thr Glu Asn Lys Asn Phe Asp Thr Glu Ile Phe Gly Ile 
385                 390                 395                 400 


Phe Lys Lys His Tyr Lys Val Asn Phe Asp Ser Lys Lys Phe Ser Asn 
                405                 410                 415     


Lys Ser Asp Glu Glu Lys Glu Leu Tyr Lys Ile Ile Tyr Arg Tyr Leu 
            420                 425                 430         


Lys Gly Arg Ile Glu Lys Ile Leu Val Asn Glu Gln Lys Val Arg Leu 
        435                 440                 445             


Lys Lys Thr Glu Lys Ile Glu Ile Glu Lys Ile Leu Asn Glu Ser Ile 
    450                 455                 460                 


Leu Ser Glu Lys Ile Leu Lys Arg Val Lys Gln Tyr Thr Leu Glu His 
465                 470                 475                 480 


Ile Met Tyr Leu Gly Lys Leu Arg His Asn Asp Ile Val Lys Met Thr 
                485                 490                 495     


Val Asn Thr Asp Asp Phe Ser Arg Leu His Ala Lys Glu Glu Leu Asp 
            500                 505                 510         


Leu Glu Leu Ile Thr Phe Phe Ala Ser Thr Asn Met Glu Leu Asn Lys 
        515                 520                 525             


Ile Phe Asn Gly Lys Glu Lys Val Thr Asp Phe Phe Gly Phe Asn Leu 
    530                 535                 540                 


Asn Gly Gln Lys Ile Thr Leu Lys Glu Lys Val Pro Ser Phe Lys Leu 
545                 550                 555                 560 


Asn Ile Leu Lys Lys Leu Asn Phe Ile Asn Asn Glu Asn Asn Ile Asp 
                565                 570                 575     


Glu Lys Leu Ser His Phe Tyr Ser Phe Gln Lys Glu Gly Tyr Leu Leu 
            580                 585                 590         


Arg Asn Lys Ile Leu His Asn Ser Tyr Gly Asn Ile Gln Glu Thr Ile 
        595                 600                 605             


Asn Leu Lys Gly Glu Tyr Glu Asn Val Glu Asn Leu Ile Lys Glu Leu 
    610                 615                 620                 


Lys Val Ser Asn Glu Glu Ile Ser Lys Ser Leu Asn Leu Asp Ile Ile 
625                 630                 635                 640 


Phe Glu Gly Lys Val Asp Ile Ile Asn Lys Ile Asn Ser Leu Glu Ile 
                645                 650                 655     


Gly Glu Tyr Lys Asp Lys Lys Tyr Leu Pro Ser Phe Ser Lys Ile Val 
            660                 665                 670         


Pro Glu Ile Met Arg Lys Phe Arg Glu Ile Asn Lys Asp Lys Ser Phe 
        675                 680                 685             


Asp Ile Glu Ser Glu Lys Ile Ile Leu Asn Ala Val Gln Tyr Val Asn 
    690                 695                 700                 


Lys Ile Leu Tyr Glu Lys Ile Thr Ser Asn Glu Glu Asn Glu Phe Ile 
705                 710                 715                 720 


Lys Thr Leu Pro Asp Lys Leu Val Lys Lys Asn Asn Asn Lys Glu Asn 
                725                 730                 735     


Lys Asn Ser Leu Ser Ile Glu Glu Tyr Tyr Lys Asn Ala Gln Ile Ser 
            740                 745                 750         


Ser Ser Lys Gly Asp Lys Lys Ala Ile Lys Lys Tyr Gln Asn Lys Val 
        755                 760                 765             


Thr Asn Thr Tyr Ile Glu Tyr Leu Glu Asn Thr Phe Val Glu Val Ile 
    770                 775                 780                 


Asp Phe Ser Asn Phe Asn Leu Asn Phe Asp Glu Ile Lys Thr Lys Ile 
785                 790                 795                 800 


Glu Glu Arg Lys Tyr Ser Lys Ser Lys Ile Thr Ile Asp Ser Ile Ser 
                805                 810                 815     


Thr Asn Ile Asn Ile Thr Asn Asp Ile Glu Tyr Ile Ile Ser Ile Phe 
            820                 825                 830         


Ala Leu Leu Asn Ser Asn Thr Tyr Ile Asn Lys Ile Arg Asn Arg Phe 
        835                 840                 845             


Phe Ala Thr Ser Val Trp Leu Glu Lys Gln Asn Ser Thr Lys Glu Tyr 
    850                 855                 860                 


Asp Tyr Lys Asn Ile Ile Ser Ile Leu Asp Glu Val Leu Leu Thr Asn 
865                 870                 875                 880 


Leu Leu Arg Glu Asn Asn Ile Thr Asp Ile Leu Asp Leu Lys Asn Ala 
                885                 890                 895     


Ile Ile Asp Ala Lys Ile Val Glu Asn Asp Glu Ala Tyr Ile Lys Asn 
            900                 905                 910         


Tyr Ile Phe Glu Ser Asn Glu Glu Lys Leu Lys Lys Arg Leu Phe Cys 
        915                 920                 925             


Glu Glu Leu Ile Asp Lys Glu Asp Ile Arg Lys Ile Phe Glu Asp Lys 
    930                 935                 940                 


Asn Phe Lys Phe Lys Asn Phe Ile Lys Lys Thr Gly Asn Glu Asn Phe 
945                 950                 955                 960 


Thr Ile Asp Phe Asp Ile Leu Phe Asn Leu Glu Cys Asn Ser Glu Leu 
                965                 970                 975     


Asn Ala Lys Lys Val Ile Gly Gln Asn Ser Gln Arg Leu Asn Leu Phe 
            980                 985                 990         


Ile Lys Asn Thr Ile Asp Glu Tyr  Lys Ser Lys Ile Lys  Thr Ser Phe 
        995                 1000                 1005             


Ser Ser  Glu Phe Leu Gly Lys  Tyr Lys Lys Glu Ile  Asp Asn Leu 
    1010                 1015                 1020             


Val Glu  Asp Thr Glu Ser Glu  Asn Lys Asn Lys Phe  Glu Lys Ile 
    1025                 1030                 1035             


Tyr Tyr  Pro Glu Glu His Lys  Asn Glu Leu Tyr Ile  Tyr Lys Lys 
    1040                 1045                 1050             


Asn Leu  Phe Leu Asn Ile Gly  Asn Pro Asn Phe Asp  Lys Ile Tyr 
    1055                 1060                 1065             


Gly Ile  Ile Ser Lys Asp Ile  Lys Asn Val Asn Thr  Glu Ile Leu 
    1070                 1075                 1080             


Phe Asp  Asp Asp Ile Arg Lys  Asn Lys Ile Ser Glu  Ile Asp Ala 
    1085                 1090                 1095             


Ile Leu  Lys Asn Leu Asn Asp  Lys Leu Asn Gly Tyr  Ser Asn Asp 
    1100                 1105                 1110             


Tyr Lys  Ala Lys Tyr Val Asn  Lys Leu Lys Glu Asn  Asp Asp Phe 
    1115                 1120                 1125             


Phe Ala  Lys Asn Met Lys Asn  Glu Asn Tyr Ser Ser  Phe Gly Glu 
    1130                 1135                 1140             


Phe Glu  Lys Asp Tyr Asn Lys  Val Ser Glu Tyr Lys  Lys Ile Arg 
    1145                 1150                 1155             


Asp Leu  Val Glu Phe Asn Tyr  Leu Asn Lys Ile Glu  Ser Tyr Leu 
    1160                 1165                 1170             


Ile Asp  Ile Asn Trp Lys Leu  Ala Ile Gln Met Ala  Arg Phe Glu 
    1175                 1180                 1185             


Arg Asp  Met His Tyr Ile Val  Asn Gly Leu Arg Glu  Leu Gly Ile 
    1190                 1195                 1200             


Ile Lys  Leu Ser Gly Tyr Asn  Thr Gly Ile Ser Arg  Ala Tyr Pro 
    1205                 1210                 1215             


Lys Arg  Asn Gly Ser Asp Gly  Phe Tyr Thr Thr Thr  Ala Tyr Tyr 
    1220                 1225                 1230             


Lys Phe  Phe Asp Glu Glu Ser  Tyr Lys Lys Phe Glu  Lys Ile Cys 
    1235                 1240                 1245             


Tyr Gly  Phe Gly Ile Asp Leu  Ser Glu Asn Ser Glu  Ile Asn Lys 
    1250                 1255                 1260             


Pro Glu  Asn Glu Ser Ile Arg  Asn Tyr Ile Ser His  Phe Tyr Ile 
    1265                 1270                 1275             


Val Arg  Asn Pro Phe Ala Asp  Tyr Ser Ile Ala Gln  Gln Ile Asp 
    1280                 1285                 1290             


Arg Val  Ser Asn Leu Leu Ser  Tyr Ser Thr Arg Tyr  Asn Asn Ser 
    1295                 1300                 1305             


Thr Tyr  Ala Ser Val Phe Glu  Val Phe Lys Lys Asp  Val Asp Leu 
    1310                 1315                 1320             


Asp Tyr  Asp Lys Leu Lys Thr  Lys Phe Lys Leu Phe  Asp Asp Glu 
    1325                 1330                 1335             


Lys Asn  Asn Asp Ile Lys Ile  Leu Lys Ile Lys Asp  Leu Ile Glu 
    1340                 1345                 1350             


Ser Lys  Lys Val Ser Val Leu  Glu Leu Lys Ser Tyr  Asn Ser Asp 
    1355                 1360                 1365             


Tyr Ile  Lys Asn Leu Ile Ile  Glu Leu Leu Thr Lys  Val Glu Asn 
    1370                 1375                 1380             


Lys Asp  Glu Ile Ser Ser 
    1385                 


<210>  205
<211>  1193
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  205

Met Lys Val Thr Lys Ile Asp Gly Leu Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Phe Lys Asn Asn Lys Asn Ile Asn Glu Ile 
            20                  25                  30          


Lys Glu Arg Leu Lys Lys Leu Lys Glu Leu Lys Leu Asp Asn Tyr Ile 
        35                  40                  45              


Lys Asn Pro Glu Asn Val Lys Asn Lys Asp Lys Asp Ala Glu Lys Glu 
    50                  55                  60                  


Thr Lys Ile Arg Arg Thr Asn Leu Lys Lys Tyr Phe Ser Glu Ile Ile 
65                  70                  75                  80  


Leu Arg Lys Glu Asp Glu Lys Tyr Ile Leu Lys Lys Thr Lys Lys Phe 
                85                  90                  95      


Lys Asn Ile Asn Gln Glu Ile Asp Tyr Tyr Asp Val Lys Ser Lys Lys 
            100                 105                 110         


Asn Gln Gln Glu Ile Phe Asp Val Leu Lys Glu Ile Lys Ile Lys Glu 
        115                 120                 125             


Thr Glu Lys Glu Glu Ile Ile Thr Phe Asp Ser Glu Lys Leu Lys Lys 
    130                 135                 140                 


Val Phe Gly Glu Asp Phe Val Lys Lys Glu Ala Lys Ile Lys Ala Ile 
145                 150                 155                 160 


Glu Lys Ser Leu Lys Ile Asn Lys Ala Asn Tyr Lys Lys Asp Ser Ile 
                165                 170                 175     


Lys Ile Gly Asp Asp Lys Tyr Ser Asn Val Lys Gly Glu Asn Lys Arg 
            180                 185                 190         


Ser Cys Ile Tyr Glu Tyr Tyr Lys Lys Ser Glu Asn Leu Lys Lys Phe 
        195                 200                 205             


Glu Glu Asn Ile Arg Glu Ala Phe Glu Lys Leu Tyr Thr Glu Glu Asn 
    210                 215                 220                 


Ile Lys Glu Leu Tyr Ser Lys Ile Glu Glu Val Leu Lys Lys Thr His 
225                 230                 235                 240 


Leu Lys Ser Ile Val Arg Glu Phe Tyr Gln Asn Glu Ile Ile Gly Glu 
                245                 250                 255     


Ser Glu Phe Ser Lys Lys Asn Gly Asp Gly Ile Ser Ile Leu Tyr Asn 
            260                 265                 270         


Gln Ile Lys Asp Ser Ile Lys Lys Glu Glu Asn Phe Ile Glu Phe Ile 
        275                 280                 285             


Glu Asn Ile Gly Asn Leu Glu Leu Lys Asp Leu Thr Lys Ser Gln Ile 
    290                 295                 300                 


Phe Tyr Lys Tyr Phe Leu Glu Asn Glu Glu Leu Asn Asp Glu Asn Ile 
305                 310                 315                 320 


Lys Phe Ala Phe Cys Tyr Phe Val Glu Ile Glu Val Asn Asn Leu Leu 
                325                 330                 335     


Lys Glu Asn Val Tyr Lys Ile Lys Arg Phe Asn Glu Gly Asn Lys Lys 
            340                 345                 350         


Arg Ile Lys Asn Ile Phe Glu Tyr Asp Lys Leu Lys Lys Leu Ile Val 
        355                 360                 365             


Tyr Lys Leu Glu Asn Lys Leu Asn Asn Tyr Val Arg Asn Cys Gly Lys 
    370                 375                 380                 


Tyr Asn Tyr His Met Glu Asn Gly Asp Ile Ala Thr Ser Asp Ile Asn 
385                 390                 395                 400 


Met Arg Asn Arg Gln Thr Glu Ala Phe Leu Arg Ser Ile Ile Gly Val 
                405                 410                 415     


Ser Ser Phe Gly Tyr Phe Ser Leu Arg Asn Ile Leu Gly Val Asn Asp 
            420                 425                 430         


Asp Asp Phe Tyr Glu Ile Glu Glu Gly Leu Thr Glu Glu Glu Arg Lys 
        435                 440                 445             


Asn Glu Ser Asn Val Leu Lys Lys Ala Lys Glu Asp Ile Thr Ser Lys 
    450                 455                 460                 


Ser Ile Phe Glu Lys Val Val Asp Lys Ser Phe Glu Lys Lys Gly Ile 
465                 470                 475                 480 


Arg Ser Ile Lys Glu Asn Leu Lys Met Phe Tyr Gly Asp Ser Phe Asp 
                485                 490                 495     


Lys Ala Asn Gly Asp Glu Leu Lys Gln Phe Phe Val Asn Met Leu Asn 
            500                 505                 510         


Ala Ile Thr Ser Ile Arg His Ser Val Val His Tyr Asp Met Asn Thr 
        515                 520                 525             


Asn Ser Glu Asn Ile Phe Asn Phe Ser Asp Ile Glu Val Ser Arg Leu 
    530                 535                 540                 


Leu Lys Ser Ile Phe Glu Lys Glu Thr Asp Lys Arg Glu Leu Lys Leu 
545                 550                 555                 560 


Lys Ile Phe Arg Gln Leu Asn Ser Ala Gly Val Phe Asp Tyr Trp Glu 
                565                 570                 575     


Asn Trp Lys Ile Lys Lys Tyr Leu Glu Asn Ile Lys Phe Glu Phe Val 
            580                 585                 590         


Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys Leu Tyr Asn Arg 
        595                 600                 605             


Ile Asp Asn Leu Lys Gly Ser Asn Ala Leu Asn Leu Gly Tyr Ile Asn 
    610                 615                 620                 


Ile Pro Lys Arg Lys Glu Ala Arg Asp Ser Gln Ile Tyr Leu Leu Lys 
625                 630                 635                 640 


Asn Ile Tyr Tyr Gly Lys Phe Val Glu Asn Phe Val Asn Asn Lys Glu 
                645                 650                 655     


Asn Phe Glu Lys Val Phe Lys Lys Ile Ile Glu Ile Asn Lys Asn Ala 
            660                 665                 670         


Gly Arg Asn Lys Gln Thr Asn Phe Tyr Lys Leu Glu Lys Phe Glu Thr 
        675                 680                 685             


Leu Lys Ala Asn Thr Pro Thr Glu Tyr Leu Glu Lys Leu Gln Ser Leu 
    690                 695                 700                 


His Lys Ile Asn Tyr Asp Lys Glu Lys Val Glu Glu Asp Lys Asp Thr 
705                 710                 715                 720 


Tyr Val Asp Phe Val Gln Lys Ile Phe Leu Lys Gly Phe Ile Asn Tyr 
                725                 730                 735     


Leu Gln Lys Ser Asn Ser Leu Lys Pro Leu Asn Leu Leu Asn Leu Lys 
            740                 745                 750         


Lys Asp Glu Val Ile Asn Ser Glu Lys Ser Ser Tyr Asp Glu Lys Leu 
        755                 760                 765             


Lys Gln Trp Glu Asn Asn Gly Ser Lys Leu Ser Glu Met Pro Lys Glu 
    770                 775                 780                 


Ile Tyr Glu Tyr Ile Lys Lys Ile Gln Ile Asn Lys Ile Asn Tyr Ser 
785                 790                 795                 800 


Asp Arg Met Ser Ile Phe Tyr Leu Leu Leu Lys Leu Ile Asp His Lys 
                805                 810                 815     


Glu Leu Thr Asn Leu Arg Gly Asn Leu Glu Lys Tyr Glu Ser Met Asn 
            820                 825                 830         


Lys Asn Lys Ile Tyr Ser Glu Glu Leu Asn Ile Val Asn Leu Val Ser 
        835                 840                 845             


Leu Asp Asn Asn Lys Val Arg Thr Asn Phe Ser Val Glu Ala Glu Asp 
    850                 855                 860                 


Ile Gly Lys Phe Leu Lys Thr Glu Thr Ser Ile Lys Asn Asn Lys Gln 
865                 870                 875                 880 


Leu Asn Asn Phe Ser Glu Ile Phe Ala Asp Gly Gln Asn Val Ile Lys 
                885                 890                 895     


His Arg Ser Phe Tyr Asn Ile Lys Lys Tyr Gly Ile Leu Asp Leu Leu 
            900                 905                 910         


Glu Lys Ile Val Ala Lys Ala Asp Leu Lys Ile Thr Lys Glu Glu Ile 
        915                 920                 925             


Lys Lys Tyr Lys Asn Leu Gln Lys Glu Leu Glu Lys Asn Asp Phe Tyr 
    930                 935                 940                 


Lys Ile Gln Glu Lys Ile His Arg Lys Tyr Asn Gln Lys Pro Asn Leu 
945                 950                 955                 960 


Ile Ser Arg Thr Glu Asn Lys Lys Asp Phe Asn Asp Tyr Lys Lys Ala 
                965                 970                 975     


Ile Glu Asn Ile Gln Asn Tyr Thr Gln Leu Lys Asn Lys Ile Glu Phe 
            980                 985                 990         


Asn Asp Leu Asn Leu Leu Gln Asp  Leu Leu Phe Arg Ile  Leu His Arg 
        995                 1000                 1005             


Leu Ala  Gly Tyr Thr Ser Leu  Trp Glu Arg Asp Leu  Gln Phe Lys 
    1010                 1015                 1020             


Leu Lys  Gly Glu Phe Pro Glu  Asp Lys Tyr Ile Asp  Glu Ile Phe 
    1025                 1030                 1035             


Asn Ser  Asp Arg Asn Asn Asn  Gln Lys Tyr Lys Ser  Gly Gly Ile 
    1040                 1045                 1050             


Ala Tyr  Lys Tyr Val Asp Phe  Leu Ile Glu Lys Glu  Glu Gly Lys 
    1055                 1060                 1065             


Arg Ala  Gly Lys Asn Lys Val  Lys Lys Arg Ser Glu  Lys Glu Gly 
    1070                 1075                 1080             


Ser Phe  Ile Ile Arg Asn Tyr  Ile Ala His Phe Asn  Tyr Ile Pro 
    1085                 1090                 1095             


Asp Ala  Glu Lys Ser Ile Leu  Glu Ile Leu Glu Glu  Leu Arg Glu 
    1100                 1105                 1110             


Leu Leu  Lys Tyr Asp Arg Lys  Leu Lys Asn Ala Val  Met Lys Ser 
    1115                 1120                 1125             


Ile Lys  Asp Ile Phe Lys Glu  Tyr Gly Phe Ile Ile  Glu Phe Gly 
    1130                 1135                 1140             


Ile Ser  His Glu Ser Asn Ser  Lys Lys Ile Lys Val  Val Asn Val 
    1145                 1150                 1155             


Glu Ser  Glu Lys Ile Lys His  Leu Lys Asn Asn Gly  Leu Val Thr 
    1160                 1165                 1170             


Thr Arg  Asn Ser Glu Asp Leu  Cys Asn Leu Val Lys  Val Met Leu 
    1175                 1180                 1185             


Glu Tyr  Lys Lys Ser 
    1190             


<210>  206
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  206

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Asn Glu Lys Asn Thr Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Tyr Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Val Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Phe Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Ile Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Lys Ile Pro Tyr Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asn Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Lys Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Lys Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Glu  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  207
<211>  1373
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  207

Met Ala Lys His Leu Arg Pro Ile Gly Glu Ser Tyr Thr Asp Phe Leu 
1               5                   10                  15      


Asp Glu Thr Glu Phe Val Arg Leu Gly Arg Gly Leu His Arg Gly His 
            20                  25                  30          


His Gly Val Gln Ile Pro Pro Thr Glu Leu Pro Ser Tyr Leu Ala Glu 
        35                  40                  45              


Tyr Arg Lys Ala Leu Met Arg Gln Val Val Ala Val Leu Asp Lys Val 
    50                  55                  60                  


Val Gly Lys Arg Arg Arg Leu Ser Gly Met His Pro Glu Ala Tyr Arg 
65                  70                  75                  80  


Asp Arg Val His Leu Ala Glu Ala Leu Trp Val Arg Leu Val Ala Arg 
                85                  90                  95      


Val Lys Glu Ile Gly Thr Pro Pro Asp Pro Ser Glu Leu Leu Asp Leu 
            100                 105                 110         


Arg Arg Met Trp Asn Ala Lys Ala His Pro Tyr Ala Glu Tyr Asp Val 
        115                 120                 125             


Val Pro Arg Ala Pro Leu Asn Asp Gly Asn Gly Gln Lys Ile Leu Glu 
    130                 135                 140                 


Cys Arg Glu Val Asp Asp Pro Lys Ile Glu Arg Ser Asp Phe Glu Gly 
145                 150                 155                 160 


Arg Trp His Gly Arg Phe Trp Gln Ser Glu Pro Gly Pro Val Asp Tyr 
                165                 170                 175     


Asn Ala Ile Ala Asp Arg Ile Phe Ala His Leu Phe Asp Gln Glu Ala 
            180                 185                 190         


Val Ile Gly Gly Gly Pro Arg Arg Glu Gly Asn Val Thr Val Pro Asp 
        195                 200                 205             


Glu Asp Ile Asn Gly Gln Pro Gly Pro Ala Thr Gly Lys Gly Leu Ile 
    210                 215                 220                 


Ile Ala Arg Gly Gln Ser Ile Val Lys Ser Ala Ser Asp Pro Arg Arg 
225                 230                 235                 240 


Ser Ser Lys Lys Val Gln Arg Thr Trp Asp Lys Ala Val Glu Arg Arg 
                245                 250                 255     


Tyr Phe Gly Asp Asp Gly Lys Gly Gly Ser Asp Ile Ala Lys Ala Ile 
            260                 265                 270         


Tyr Glu Glu Leu Gly Asp Pro Ala Thr Leu Ala Asp Pro Ile Tyr Ala 
        275                 280                 285             


Ser Trp Phe Gly Ser Arg Leu Tyr Asp His Phe Gly Ser Phe Lys Asn 
    290                 295                 300                 


Ser Leu Pro Leu Glu Leu Lys Asp Pro Phe Lys Glu Gln Ile Trp Ala 
305                 310                 315                 320 


Leu His Asn Ser Val Arg Gln Phe Tyr Gln Arg Met Ala Lys Ser Asp 
                325                 330                 335     


Arg Phe Arg Leu Ala Leu Gln Asn Ala Arg Ser Glu Val Pro Asp Arg 
            340                 345                 350         


Ser Glu Leu Leu Ala Leu Leu Pro Lys Asp His Asp His Leu Leu Leu 
        355                 360                 365             


Val Leu Gly Gly Lys Lys Lys Asn Ala Glu Met Ser Glu Leu Ile Arg 
    370                 375                 380                 


Leu Gly Lys Leu Phe Val His Ala Ser Asp Val Leu His Asp Phe Asp 
385                 390                 395                 400 


Ala Asn Asp Ala Ala Ala Leu Asp Ala Phe Lys Arg Arg Met Ser Phe 
                405                 410                 415     


Leu Ala Thr Ser Ile Gly Gln Ser Glu Ile Lys Gln Thr Glu Thr Phe 
            420                 425                 430         


Ala Arg Thr Trp Arg Gly Ala Val Gly Leu Thr Leu Arg Thr Val Lys 
        435                 440                 445             


Gly Leu Ala Asp Pro Arg Gly Ile Ile Gly Thr Pro Asp Asn Arg Asp 
    450                 455                 460                 


Leu Gly Thr Ala Gly Pro Met Lys Asp Ala Phe Asn Lys Phe Asp Gln 
465                 470                 475                 480 


Pro His Phe Gln Gln His Met Thr Ile Ile Phe Gly Asn Lys Glu Leu 
                485                 490                 495     


Gln Ala Glu Gly Asn Pro Thr Arg Ser Ser Val Phe Thr Ala Asn Gly 
            500                 505                 510         


Asp Lys Asp His Gln Ala Glu Leu Leu Trp Gly Phe Leu Cys Val Val 
        515                 520                 525             


Arg Ser Val Arg Asn Arg Thr Asn His Tyr Asn Val Arg Arg Ala Leu 
    530                 535                 540                 


Phe Arg Leu Leu Asp Glu Gly Ile Val Ser Pro Met Pro Ser Asp Pro 
545                 550                 555                 560 


Lys Lys Glu Arg Val Glu Asn Arg Asn Leu Cys Thr Val Ser Pro Thr 
                565                 570                 575     


Ala Leu Glu Ala Phe Arg Arg Leu Leu Asn Phe Asp Leu Ala Ile Gln 
            580                 585                 590         


Lys Glu Ala Val Arg Thr Ala Leu Glu Gln Ala Lys Ala Ser Glu Phe 
        595                 600                 605             


Val Glu Glu Gly Lys Leu Arg Gly Leu Val Ser Glu Leu Ala Gly Thr 
    610                 615                 620                 


Glu Asp Met Pro Ala Leu His Ile Pro Arg Phe Ser Ala Val Met Asp 
625                 630                 635                 640 


Lys Val Arg Arg Leu Ala Asp Asn Arg Asp Val Gly Leu Asp Pro Ile 
                645                 650                 655     


Leu Ser Thr Leu Gln Arg Ser Leu Pro Pro Thr Asp Lys Gln Ala Glu 
            660                 665                 670         


Ser Asp Ala Ala Arg Cys Arg Tyr Arg Leu Leu Leu Glu Leu Tyr Lys 
        675                 680                 685             


Ser Gly Phe Arg Ser Trp Phe Ser Gly Ile Gln Ser Asn Glu Glu Asn 
    690                 695                 700                 


Asn Arg Glu Ile Cys His Trp Ala Val Lys Gln Val Gly Arg Ala Lys 
705                 710                 715                 720 


Asp Ala Arg Lys Ser Glu Tyr Asp Lys Lys Thr Lys Arg His Tyr Arg 
                725                 730                 735     


Ser Pro Asn Ser Leu Ile Asp Asp Leu Gly Leu Asp Lys Phe Asp Asp 
            740                 745                 750         


Leu Thr Asp Leu Leu Glu Ala Leu Ala Ser Gln Ser Thr Arg Glu His 
        755                 760                 765             


Asp Gln Asn Leu Lys Tyr Val Pro Asp Ala Arg Val Gln Ser Gln Met 
    770                 775                 780                 


Ser Asn Arg Ile Glu Glu Phe Arg Gln Glu Leu Phe Ala His Ile Phe 
785                 790                 795                 800 


Thr Lys Tyr Leu Asp Thr His Asp Phe Gly Trp Ile Gly Ala Ile Glu 
                805                 810                 815     


Val Arg Arg Glu Ala Cys Asp Leu Ala Asp Val Val Ser Ala Phe Glu 
            820                 825                 830         


Val Arg Asp Gln Lys Phe Asp Ala Asp Trp His Ser Gln Phe Tyr Ala 
        835                 840                 845             


Trp Leu Tyr Met Val Pro Pro Ile Glu Ala Ser Arg Leu Arg His Gln 
    850                 855                 860                 


Met Arg Lys Ser Ala Val Met Asp Asp Lys Trp Ser Thr Thr Leu Glu 
865                 870                 875                 880 


Leu Thr Ser Gly Asp Arg Lys Thr Arg Asp Asp His Ala Gln Asp Val 
                885                 890                 895     


Leu Ala Asp Met Asp Arg Leu Phe Ser Leu Tyr Thr Lys Val Gln Ala 
            900                 905                 910         


Ala Gly Phe Asn Gly Gln Glu His Glu Ser Ala Leu Gly Ser Lys Ser 
        915                 920                 925             


Leu Phe Tyr Glu Asp Gly Asn Gln Phe Asp Glu Val Tyr Ser Pro Asp 
    930                 935                 940                 


Thr Glu Thr His Asn Lys Thr Phe Pro Gly Thr Arg Arg Gly Leu Arg 
945                 950                 955                 960 


Gln Leu Val Arg Tyr Ala His Leu Pro Ala Leu Glu Gly Val Phe Lys 
                965                 970                 975     


Lys His Arg Ile Thr Lys Ala Glu Val Glu Thr Phe Val Ala Leu Tyr 
            980                 985                 990         


Asp Glu Asn Arg Arg Asp Pro Gly  Ser Val Ala His Met  Leu Arg Arg 
        995                 1000                 1005             


Glu Lys  Leu Arg Thr Glu Ile  Leu Arg Ser Ile His  Asp Gly Pro 
    1010                 1015                 1020             


Lys Pro  Lys Asp Lys Asp Phe  Trp Pro Lys Leu Glu  Ala Lys Cys 
    1025                 1030                 1035             


Leu Glu  Tyr Arg Thr Val Ala  Thr Glu Thr Ala Ile  Tyr Asn Phe 
    1040                 1045                 1050             


Gln Ala  Asn Ala Ala Arg Leu  Asn Asp His Ala Arg  Leu His Gln 
    1055                 1060                 1065             


Ile Val  Met Arg Val Val Ala  Arg Leu Thr Asp Tyr  Ala Leu Ile 
    1070                 1075                 1080             


Trp Glu  Arg Asp Arg Leu Phe  Ala Phe Val Gly Met  Leu Tyr Arg 
    1085                 1090                 1095             


Gln Thr  Gly Gly Thr Gly Ile  Asn Pro Ala Met Arg  His Ala Glu 
    1100                 1105                 1110             


Lys Thr  Asn Ala Pro Pro Arg  Ile Gly Ile Leu Val  Ser Asp Ser 
    1115                 1120                 1125             


Ala Leu  Ala Lys Lys Leu Asn  Ser Asn Ser Ala Glu  Val Phe Ile 
    1130                 1135                 1140             


Pro Tyr  Leu Asp Thr Glu Thr  Gly Phe Asp Ala Pro  Arg Phe Asp 
    1145                 1150                 1155             


Asp Leu  Cys Thr Leu Leu Ser  His Glu His Ala Lys  Glu Phe Arg 
    1160                 1165                 1170             


Phe His  Phe Leu Glu Val Gly  Glu Glu Asn Ser Lys  Asp Glu Ala 
    1175                 1180                 1185             


Arg Arg  Leu Asn Glu Glu Thr  Met Gly His Arg Lys  Arg Pro Ala 
    1190                 1195                 1200             


Phe Lys  Arg Gly Thr Arg Arg  Gln Gly Ile Arg Asn  Asp Leu Ala 
    1205                 1210                 1215             


His His  Asn Val Leu Asp Leu  Ala Gly Gly Ala Gly  Pro Asn Leu 
    1220                 1225                 1230             


Thr Tyr  Met Val Asn Ala Val  Arg Ser Leu Leu Ser  Tyr Asp Arg 
    1235                 1240                 1245             


Lys Leu  Lys Asn Ala Val Pro  Lys Ser Ile Lys Arg  Ile Leu Gly 
    1250                 1255                 1260             


Glu Glu  Gly Leu Ile Ile Glu  Trp Gln Met Asn Tyr  Asp Arg Leu 
    1265                 1270                 1275             


Lys Lys  Pro Thr Val Tyr Pro  Asn Val Glu Thr His  Leu Thr Met 
    1280                 1285                 1290             


Val Pro  Pro Arg His Met Thr  Ala Pro Val Ser Phe  Thr Leu Pro 
    1295                 1300                 1305             


Arg Ala  Ser Val Arg Leu Ala  Ser Met Val Lys Ala  Val Phe Asp 
    1310                 1315                 1320             


Phe Gly  Ser Ser Gly Tyr Gly  Glu Glu Arg Met Ile  Gly Gly Arg 
    1325                 1330                 1335             


Thr Ala  Lys Gln Ala Val Tyr  Pro Asp Asp Phe Thr  Arg Arg Phe 
    1340                 1345                 1350             


Pro Gln  Thr Pro Met Gly Leu  Lys Gln Ala Thr Arg  Leu Val Phe 
    1355                 1360                 1365             


Ala Ser  Glu Asn Ser 
    1370             


<210>  208
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  208

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Asn Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys His Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Asn Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Glu 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Val Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Thr Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Lys Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Glu  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  209
<211>  1182
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  209

Met Lys Gly Gly Ser Met Lys Ile Thr Lys Val Asp Gly Leu Ser His 
1               5                   10                  15      


Tyr Lys Lys Gln Asp Lys Gly Ile Leu Lys Lys Lys Trp Arg Asp Leu 
            20                  25                  30          


Asp Glu Arg Lys Gln Arg Glu Lys Ile Glu Glu Arg Tyr Asn Lys Gln 
        35                  40                  45              


Ile Glu Ser Lys Ile Tyr Lys Glu Phe Phe Arg Leu Lys Asn Lys Lys 
    50                  55                  60                  


Arg Ile Glu Lys Glu Glu Asp Gln Asn Ile Lys Ser Leu Tyr Phe Phe 
65                  70                  75                  80  


Ile Lys Glu Met Tyr Leu Asn Glu Glu Asn Glu Glu Trp Glu Leu Lys 
                85                  90                  95      


Asn Ile Asn Leu Glu Ile Leu Asp Asp Lys Glu Arg Val Ile Lys Gly 
            100                 105                 110         


Tyr Lys Phe Lys Glu Asp Val Tyr Phe Phe Lys Glu Gly Asp Lys Lys 
        115                 120                 125             


Tyr Tyr Leu Arg Thr Leu Leu Asn Asn Leu Ile Glu Lys Ile Gln Asn 
    130                 135                 140                 


Glu Asn Arg Asp Lys Val Arg Lys Asn Lys Glu Phe Ser Asp Leu Lys 
145                 150                 155                 160 


Glu Ile Phe Lys Lys Tyr Lys Asp Arg Lys Ile Lys Leu Leu Leu Glu 
                165                 170                 175     


Ser Ile Asn Asn Asn Lys Ile Asn Leu Glu Tyr Lys Lys Glu Asn Val 
            180                 185                 190         


Asn Glu Glu Ile Tyr Gly Ile Asn Pro Thr Asn Asp Arg Glu Met Thr 
        195                 200                 205             


Phe His Glu Leu Leu Lys Glu Ile Ile Glu Lys Lys Asp Glu Gln Lys 
    210                 215                 220                 


Ser Ile Leu Glu Glu Lys Leu Asp Asn Phe Asp Ile Thr Asn Phe Leu 
225                 230                 235                 240 


Glu Asn Ile Glu Lys Ile Phe Asn Glu Glu Thr Glu Ile Asn Ile Ile 
                245                 250                 255     


Lys Gly Lys Val Leu Asn Glu Leu Arg Glu Tyr Ile Arg Glu Lys Glu 
            260                 265                 270         


Glu Asn Asn Ser Asp Tyr Lys Leu Lys Gln Ile Tyr Asn Leu Glu Leu 
        275                 280                 285             


Lys Lys Tyr Ile Glu Asn Asn Phe Ser Tyr Lys Lys Gln Lys Ser Lys 
    290                 295                 300                 


Ser Lys Asn Gly Lys Asn Asp Tyr Leu Tyr Leu Asn Phe Leu Lys Lys 
305                 310                 315                 320 


Ile Met Phe Ile Glu Glu Val Asp Glu Lys Lys Gly Ile Asn Lys Glu 
                325                 330                 335     


Lys Phe Lys Asn Lys Ile Asn Ser Asn Phe Lys Asn Leu Phe Val Gln 
            340                 345                 350         


His Ile Leu Asp Tyr Gly Lys Leu Leu Tyr Tyr Lys Glu Asn Asp Glu 
        355                 360                 365             


Tyr Ile Lys Asn Thr Gly Gln Leu Glu Thr Lys Asp Leu Glu Tyr Ile 
    370                 375                 380                 


Lys Thr Lys Glu Thr Leu Ile Arg Lys Met Ala Val Leu Val Ser Phe 
385                 390                 395                 400 


Ala Ala Asn Ser Tyr Tyr Asn Leu Phe Gly Arg Thr Glu Asn Asn Ile 
                405                 410                 415     


Leu Thr Gln Glu Ile Ser Asp Asp Leu Leu Leu Gly Lys Ile Glu Asn 
            420                 425                 430         


Glu Ile Tyr Ile Lys Gly Glu Lys Asn Arg Arg Tyr Val Phe Lys Glu 
        435                 440                 445             


Lys Met Leu Asn Tyr Phe Phe Asn Pro Glu Ile Phe Gly Asp Asn Lys 
    450                 455                 460                 


Ile Val Glu Val Leu Ser Ala Ile Ser Ser Ser Ile Tyr Asn Ile Arg 
465                 470                 475                 480 


Asn Gly Val Asn His Phe Asp Lys Ile Asn Leu Gly Gln Tyr Asn Asn 
                485                 490                 495     


Leu Asp Leu Ser Glu Ile Lys Lys Tyr Phe Ile Glu Lys Arg Asp Lys 
            500                 505                 510         


Ile Lys Glu Lys Val Lys Glu Lys Phe Ser Ser Asn Asn Leu Gln Tyr 
        515                 520                 525             


Tyr Tyr Ala Lys Lys Glu Ile Glu Asn Tyr Phe Lys Ala Tyr Glu Phe 
    530                 535                 540                 


Glu Ile Leu Lys Glu Lys Ile Pro Phe Ala Pro Asn Phe Lys Arg Ile 
545                 550                 555                 560 


Ile Lys Lys Gly Glu Asp Leu Phe Asn Asn Lys Lys Asn Lys Lys Tyr 
                565                 570                 575     


Glu Tyr Phe Lys Asn Phe Asp Lys Asn Ile Ala Glu Glu Lys Lys Glu 
            580                 585                 590         


Phe Leu Lys Thr Arg Asn Phe Leu Leu Lys Glu Leu Tyr Tyr Asn Asn 
        595                 600                 605             


Phe Tyr Lys Glu Phe Leu Ser Lys Lys Glu Glu Phe Lys Lys Val Val 
    610                 615                 620                 


Ile Glu Val Lys Glu Glu Lys Lys Asn Arg Gly Asn Ile Asn Asn Lys 
625                 630                 635                 640 


Lys Ser Gly Val Ser Phe Gln Ser Ile Asp Asp Tyr Asp Thr Lys Ile 
                645                 650                 655     


Asn Ile Ser Asp Tyr Ile Ala Ser Ile His Lys Lys Glu Met Glu Arg 
            660                 665                 670         


Val Glu Lys Tyr Asn Glu Glu Lys Gln Lys Asp Thr Ala Lys Tyr Ile 
        675                 680                 685             


Arg Asp Phe Val Glu Glu Ile Phe Leu Thr Gly Phe Ile Asn Tyr Leu 
    690                 695                 700                 


Glu Lys Asp Lys Arg Leu His Phe Leu Lys Glu Glu Phe Ser Ile Leu 
705                 710                 715                 720 


Cys Asn Asn Asn Asn Asn Val Val Asp Phe Asn Ile Asn Ile Asn Glu 
                725                 730                 735     


Glu Lys Ile Lys Glu Phe Leu Lys Glu Asn Asp Ser Lys Thr Leu Asn 
            740                 745                 750         


Leu Tyr Leu Phe Phe Asn Met Ile Asp Ser Lys Arg Ile Ser Glu Phe 
        755                 760                 765             


Arg Asn Glu Leu Ile Lys Tyr Lys Gln Phe Thr Lys Arg Arg Leu Asp 
    770                 775                 780                 


Glu Lys Lys Glu Phe Leu Gly Ile Glu Ile Glu Leu Tyr Glu Thr Leu 
785                 790                 795                 800 


Ile Glu Phe Val Ile Leu Thr Arg Glu Lys Leu Asp Thr Lys Lys Ser 
                805                 810                 815     


Glu Glu Ile Asp Ala Trp Leu Val Asp Lys Leu Tyr Val Lys Asp Asn 
            820                 825                 830         


Asn Glu Tyr Lys Glu Tyr Glu Glu Ile Leu Lys Leu Phe Val Asp Glu 
        835                 840                 845             


Lys Ile Leu Ser Ser Lys Glu Ala Pro Tyr Tyr Ala Thr Asp Asn Lys 
    850                 855                 860                 


Thr Pro Ile Leu Leu Ser Asn Phe Glu Lys Thr Arg Lys Tyr Gly Thr 
865                 870                 875                 880 


Gln Ser Phe Leu Ser Glu Ile Gln Ser Asn Tyr Lys Tyr Ser Lys Val 
                885                 890                 895     


Glu Lys Glu Asn Ile Glu Asp Tyr Asn Lys Lys Glu Glu Ile Glu Gln 
            900                 905                 910         


Lys Lys Lys Ser Asn Ile Glu Lys Leu Gln Asp Leu Lys Val Glu Leu 
        915                 920                 925             


His Lys Lys Trp Glu Gln Asn Lys Ile Thr Glu Arg Glu Ile Lys Lys 
    930                 935                 940                 


Tyr Asn Asp Thr Ile Lys Glu Ile Arg Glu Tyr Asn Tyr Leu Lys Asn 
945                 950                 955                 960 


Lys Glu Glu Leu Gln Asn Val Tyr Leu Leu His Glu Met Leu Ser Asp 
                965                 970                 975     


Leu Leu Ala Arg Asn Val Ala Phe Phe Asn Lys Trp Glu Arg Asp Phe 
            980                 985                 990         


Lys Phe Ile Val Ile Ala Ile Lys  Gln Phe Leu Arg Glu  Asn Asp Lys 
        995                 1000                 1005             


Glu Lys  Val Asn Glu Phe Leu  Asn Pro His Lys Ser  Asp Gly Ser 
    1010                 1015                 1020             


Arg Asp  Asn Phe Ser Val Thr  Asn Tyr Arg Ser Lys  Met Lys Ser 
    1025                 1030                 1035             


Ile Ile  Asn Asn Ile His Glu  Asn Phe Met Ser Leu  Leu Phe Leu 
    1040                 1045                 1050             


Asn Asn  Asn Leu Ala Thr Gly  Gly Ile Gln Met Gly  Arg Asn Asn 
    1055                 1060                 1065             


Asn Phe  Thr Trp Gly Asn Leu  Arg Asn Tyr Ile Ala  His Phe Glu 
    1070                 1075                 1080             


Tyr Leu  His Lys Glu Lys Asp  Thr Ile Ser Phe Leu  Asn Gln Ala 
    1085                 1090                 1095             


Asn Leu  Leu Ile Lys Leu Phe  Ser Tyr Asp Lys Lys  Val Gln Asn 
    1100                 1105                 1110             


His Ile  Ile Lys Ser Met Lys  Thr Leu Leu Glu Lys  Tyr Asn Ile 
    1115                 1120                 1125             


Glu Ile  Gly Phe Glu Ile Ser  Asn Asp Ser Glu Glu  Ile Phe Glu 
    1130                 1135                 1140             


Tyr Lys  Ile Lys Tyr Ile Asn  Ser Lys Lys Gly Lys  Met Leu Gly 
    1145                 1150                 1155             


Lys Asn  Asn Glu Phe Glu Ile  Leu Glu Asn Glu Phe  Val Arg Asn 
    1160                 1165                 1170             


Val Lys  Ala Leu Leu Glu Tyr  Ser Lys 
    1175                 1180         


<210>  210
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  210

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Gly Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asp 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  211
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  211

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Gly Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asp 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  212
<211>  949
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  212

Met Pro His Gln Lys Lys Met Ala Glu Arg Ile Lys Phe Val Asn Tyr 
1               5                   10                  15      


Gly Tyr Tyr Leu Arg Leu Lys Lys Asn Cys Ala Asp Ser Phe Glu Tyr 
            20                  25                  30          


Tyr Trp Cys Asp Tyr Ile Lys Glu Phe Ile Glu Glu Asn Tyr Val Thr 
        35                  40                  45              


Lys Ile Lys Glu Ala Lys Gly Lys Asn Gly Arg Gln Leu Thr Glu Glu 
    50                  55                  60                  


Asn Cys Asn Ser Glu Ala Met Leu Ser Lys Cys Trp His Asp Met Ile 
65                  70                  75                  80  


Arg His Met Cys Ala Lys Tyr Met Asp Leu Gly Lys Ala Val Tyr His 
                85                  90                  95      


Phe Met Leu Pro Gly Lys Ala Glu Gly Asn Asp Leu Cys Leu Asp Arg 
            100                 105                 110         


Leu Asn Asp Ser Phe Ser Lys Gly Ile Thr Ser Phe Asp Tyr Glu Asn 
        115                 120                 125             


Ile Lys Ala Glu Glu Asn Leu Gln Lys Ala Met Phe Gly Val Leu Val 
    130                 135                 140                 


Ser Gly Thr Phe Asn Phe Ser Arg Ser Val Ala Asp Tyr Ser Gly Pro 
145                 150                 155                 160 


Ala Ala Ala Lys Leu Ala Lys Glu Leu Arg Ala Glu Gly Lys Thr Leu 
                165                 170                 175     


Asn Glu Asp Val Leu Met Val Asp Glu Ala His Leu Lys Ala Ile Leu 
            180                 185                 190         


Tyr Ser Asp Ala Lys Arg Lys Leu Leu Arg Tyr Phe Gly Gly Ser Ser 
        195                 200                 205             


Ala Cys Glu Ala Leu Gly Leu Asp Lys Asp Lys Met Val Leu Glu Phe 
    210                 215                 220                 


Arg Gln Ile Phe Arg Gly Leu Arg Asn Ser Ala Phe His Tyr Thr Asp 
225                 230                 235                 240 


Gly Lys Lys Ala Asp Ile Lys Phe Asp Val Thr Arg Gln Leu Trp Ile 
                245                 250                 255     


Gln Asp Val Gln Ala Asn Lys Gln Leu Ile Leu Asp Lys Tyr Tyr Ser 
            260                 265                 270         


Asn Asn Val Cys Arg Tyr Tyr Lys Pro Glu Met Val Lys Lys Leu Ile 
        275                 280                 285             


Gly Asn Leu Tyr His Gly Tyr Val Glu Gln Glu Ala Gln Ile Pro Ala 
    290                 295                 300                 


Phe Arg Thr Val Trp Lys Arg Lys Asp Phe Ala Lys Tyr Leu Asn Asp 
305                 310                 315                 320 


Ser Asn Phe Leu Pro Val Asn Ile Lys Asn Asp Val Lys Glu Arg Thr 
                325                 330                 335     


Val Phe Glu Gly Ala Leu Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg 
            340                 345                 350         


Lys Tyr Thr Val Gly Gln Asp Ala Pro Lys Tyr Phe Phe Glu Ala Val 
        355                 360                 365             


Arg Ala Tyr Ser Asp Glu His Ala Lys Asn Lys Gln Asp Pro Tyr Ala 
    370                 375                 380                 


Asn Gln Ala Lys Asn Phe Trp Asp Tyr Val Glu Lys Leu Gln Lys Ser 
385                 390                 395                 400 


Tyr Glu Lys Gly Thr Leu Thr Phe Gly Ala Val Cys Gln Thr Ile Met 
                405                 410                 415     


Thr Glu Phe Val Gln Gln Asn Ser Lys Ala Thr Glu Lys Glu Gly Glu 
            420                 425                 430         


Ile Tyr Gln His Phe Lys Val Leu Phe Pro Leu Cys Met Gln Arg Gly 
        435                 440                 445             


Phe Glu Lys Tyr Val Lys Glu Lys His Gly Tyr Leu Leu Lys Pro Trp 
    450                 455                 460                 


Leu Asp Thr Val Val Arg Glu Asn Val Leu Gln Asp Ala Ala Ile Thr 
465                 470                 475                 480 


Cys Phe Asp Asp Leu Met Arg Asp Ala Glu Asp Arg Glu Tyr Ser Trp 
                485                 490                 495     


Tyr Val Val Ala His Phe Ile His Pro Lys Lys Leu Asn His Phe Val 
            500                 505                 510         


Gly Ala Leu Lys Asp Tyr Leu Gln Phe Lys Gln Asp Ile Phe Arg Arg 
        515                 520                 525             


Cys Ser Phe Ala Asn Ile Tyr Ser Glu Gly Glu Leu Ser Gln Lys Lys 
    530                 535                 540                 


Ala Met Leu Ala Glu Lys Glu Ala Glu Ile Ser Glu Ile Leu Arg Val 
545                 550                 555                 560 


Met Glu Phe Val Arg Gly Ile Thr Gly Arg Val Ser Lys Thr Phe Ser 
                565                 570                 575     


Asp Tyr Tyr Glu Asn Glu Glu Val Tyr Ala Asn Tyr Leu Gly Lys Tyr 
            580                 585                 590         


Ile Asp Phe Pro Lys Thr Asp Gly Ile Ser Val Phe Glu Ser Phe Arg 
        595                 600                 605             


Asp Phe Cys Thr Asn Thr Leu Pro Asp Gly Asn Val Leu Asp Val Tyr 
    610                 615                 620                 


Met Asp Glu Lys Asn Pro Arg Leu Leu Lys Asn Val Glu Leu Ala Arg 
625                 630                 635                 640 


Met Tyr Ala Gly Gly Asp Val Ala Leu Lys Lys Arg Lys Arg Ile Thr 
                645                 650                 655     


Ala Lys Asp Leu Gln Arg Tyr Tyr Gly Asn Glu Val Ala Val Gln Lys 
            660                 665                 670         


Ile Leu Gln Lys Gly Leu Cys Ser Thr Arg Glu Glu Gln Gln Arg Val 
        675                 680                 685             


Leu Glu Gln Gln Asn Leu Arg Gly Arg Ile Thr Leu Asn Asp Val Thr 
    690                 695                 700                 


Glu Ile Gln Glu Ile Ile Ser Asp Met Leu Ser Gln Leu Val Thr Phe 
705                 710                 715                 720 


Ser Tyr Phe Arg Glu Arg Asp Gln Met Tyr Leu Leu Leu Gly Phe Tyr 
                725                 730                 735     


Tyr Met Ala Leu Gln Thr Asn Arg Gly Ser Ser Trp Gly Asn Glu Thr 
            740                 745                 750         


Ile Asp Phe Cys Ala Gly Lys Lys Ile Ser Ile Lys Gln Gly Trp Val 
        755                 760                 765             


Leu His Gln Val Arg Ser Val Phe Thr Tyr Gly Leu Lys Leu Tyr Ser 
    770                 775                 780                 


Glu Leu Asp Glu Lys Gly Val Gly Gly Gln Leu Ser Ser Lys Ile Val 
785                 790                 795                 800 


Ala Phe Glu Arg Val His Arg Thr Ser Leu Ala Cys Ala Leu Arg Leu 
                805                 810                 815     


Phe Met Asp Glu Asn Cys Ser Arg Arg Ala Val Asp Val Arg Asn Tyr 
            820                 825                 830         


Val Asp His Phe Lys Tyr Tyr Phe Lys Ala Asp Arg Ser Ile Met Glu 
        835                 840                 845             


Leu Tyr Ser Ala Tyr Tyr Asp Cys Phe Phe Asp Tyr Ser Thr Lys Met 
    850                 855                 860                 


Arg Lys Ser Val Leu Leu Asn Phe Ile Ser Ile Leu Glu Arg His Phe 
865                 870                 875                 880 


Val Val Ser Lys Leu Arg Val Asn Cys Leu Glu Glu Arg Cys Ser Val 
                885                 890                 895     


Ser Phe Ala Glu Ser Leu Lys Ser Glu Lys Phe Thr Tyr Lys Leu Glu 
            900                 905                 910         


Ala Asp Ala Asn Lys Lys Ser Lys Glu Gln Thr Val Glu Phe Pro Ala 
        915                 920                 925             


Arg Asp Lys Glu Phe Leu Glu Ser Leu Gln Ala Glu Leu Glu Tyr Lys 
    930                 935                 940                 


Glu Gly Tyr Asn Ser 
945                 


<210>  213
<211>  1330
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  213

Met Lys Arg Glu Lys Asn Ile Thr Ile Met Lys Ile Ser Lys Val Asn 
1               5                   10                  15      


His Arg Arg Thr Ala Val Ala Leu Asn Cys Asp Lys Ser Glu Leu Gly 
            20                  25                  30          


Gly Ile Leu Tyr Glu Ala Pro Val Gln Lys Asp Lys Asn Gly Asn Tyr 
        35                  40                  45              


Asn Asp Val Ile Ala Glu Thr Gly Lys Val Val Asn Glu Ala Leu Asp 
    50                  55                  60                  


Lys Lys Ser Arg Leu Tyr Thr Pro Phe Asn Asn Gln Lys Val Ile Ile 
65                  70                  75                  80  


Asp Lys Asn Leu Gln Arg Tyr Ala Asn Asn Leu Lys Arg Cys Tyr Ile 
                85                  90                  95      


Asn Phe Val Lys Gln Tyr Val Asn Asn Lys Ser Phe Asn Tyr Lys Ala 
            100                 105                 110         


Met Gln Phe Ile Pro Asp Ile Gln Asn Pro Lys Thr Asn Asp Ala Val 
        115                 120                 125             


Asn Tyr Arg Thr Asp Arg Asp Asn Val Tyr Asn Lys Asn Lys Tyr Tyr 
    130                 135                 140                 


Asp Lys Gln Thr Lys Ser Lys Ser Lys Lys Phe Ile Tyr Glu Lys Ile 
145                 150                 155                 160 


Val Ile Pro Gln Asn Glu Gln Asn Ile Val Ile Ser Ala Leu Val Asn 
                165                 170                 175     


Cys Ser Leu Arg Lys Ser Leu Arg Lys Asp Val Ser Tyr Lys Thr Lys 
            180                 185                 190         


Ser Gly Glu Ile Lys Thr Tyr Asn Leu Pro Glu Leu Val Lys Lys Ser 
        195                 200                 205             


Met Arg Phe Tyr Cys Leu Glu Gly Gln Arg Glu Pro Asp Glu Lys Glu 
    210                 215                 220                 


Lys Tyr Glu Met Tyr Ile Leu Phe Ser Tyr Met Lys Glu Asp Lys Arg 
225                 230                 235                 240 


Thr Lys Asn Thr Asp Leu Leu Val Lys Ser Ile Ser Asn Gln Asn Thr 
                245                 250                 255     


Lys Val Lys Val Glu Asp Ile Asp Gly Asn Lys Leu Leu Lys Leu Ser 
            260                 265                 270         


Ile Ala Asp Thr Lys Lys Lys Pro Leu Trp Glu Tyr Leu Ile Lys Tyr 
        275                 280                 285             


Ala Asp Ser Ser Arg Gln Arg Glu Leu Met Tyr Asp Ile Arg Lys Lys 
    290                 295                 300                 


Ile Ile Leu Tyr Val Ala Gly Ile Glu Glu Tyr Glu Asn Ile Lys Glu 
305                 310                 315                 320 


Asp Ser Gly Leu Ser Lys Val Ser Trp Ser Lys Tyr Asn Ile Ser Asp 
                325                 330                 335     


Asn Lys Met Phe Phe Asp Ile Asn Ser Cys Thr Asp Lys Arg Lys Gln 
            340                 345                 350         


Asn Leu Glu Ile Lys Ile Arg Glu Ala Asn Ile Glu His Tyr Arg Asn 
        355                 360                 365             


Ala Ser Ser Lys Leu Cys Asp Asp Glu Ser Ile Phe Trp Phe Gln His 
    370                 375                 380                 


Phe Glu Gly Val Ile Glu Thr Leu Phe Ser Lys Lys Ser Lys Ile Ser 
385                 390                 395                 400 


Glu Glu Arg Leu Gly Cys Thr Tyr Ile Cys Asp Tyr Leu Trp Lys Asp 
                405                 410                 415     


Phe Leu Ser Tyr Leu Ala Ala Lys Tyr Ile Asp Leu Gly Lys Gly Val 
            420                 425                 430         


Tyr His Phe Thr Met Lys Asp Lys Leu Asp Met Leu Asn Lys Asn Glu 
        435                 440                 445             


Ala Val Thr Asp Leu Arg Phe Gly Ile Val Ser Glu Lys Tyr Glu Lys 
    450                 455                 460                 


Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Glu Leu 
465                 470                 475                 480 


Asp Arg Asn Ile Ala Ala Tyr Val Thr Phe Ala Ala Asp Ile Phe Ala 
                485                 490                 495     


Lys Ser Val Ile Lys Ser Asp Tyr Arg Thr Lys Lys Asp Asn Asn Ser 
            500                 505                 510         


Asp Val Leu Gln Tyr Ser Asp Lys Glu Phe Arg Asn Ser Glu Val Ile 
        515                 520                 525             


Arg Asp Asn Ala Glu Lys Asn Ile Leu Gln Tyr Trp Gly Gly Tyr Ser 
    530                 535                 540                 


Arg Trp Gly Thr Glu Asn Ser Lys Leu Pro Glu Asn Asn Lys Val Ser 
545                 550                 555                 560 


Asp Phe Gly Lys Leu Asn Val Ser Asp Leu Cys Ile Asp Ile Lys Lys 
                565                 570                 575     


His Leu Ala Gly Ile Arg Asn Ser Ser Ile His Tyr Thr Thr Lys Ile 
            580                 585                 590         


Lys Asn Glu Ser Ala Ala Asp Gly Ser Asn Val Lys Ile Leu Phe Glu 
        595                 600                 605             


Lys Asp Leu Ala Asp Ile Asn Ile Ile Tyr Ala Asp Lys Tyr Tyr Ser 
    610                 615                 620                 


Asn Asn Val Trp Met Phe Tyr Ser Leu Glu Asp Ile Asn Lys Leu Ile 
625                 630                 635                 640 


Ala Phe Leu Tyr Lys Glu Lys Arg Val Ile Arg Gln Val Gln Ile Pro 
                645                 650                 655     


Ser Phe Ser Arg Ile Leu Lys Arg Lys Ala Met Gln Asp Val Ile Asn 
            660                 665                 670         


Glu Ile Phe Lys Asp Asp Phe Asp Glu Asn Ile Val Asn Pro Glu Leu 
        675                 680                 685             


Lys Glu Lys Tyr Arg Asn Ser Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
    690                 695                 700                 


Tyr Asn Ala Phe Ile Ile Gln Pro Glu Leu Lys Glu Lys Phe Lys Asp 
705                 710                 715                 720 


Lys Ile Lys Thr Met Lys Ser Glu Leu Tyr Asn Lys Leu Lys Thr Ile 
                725                 730                 735     


Asp Lys Lys Glu Tyr Lys Ala Leu Tyr Cys Met Leu Ser Asn Glu Glu 
            740                 745                 750         


Ser Ala Leu Lys Asn Phe Ala Asp Arg Ile Tyr Ser Val Asp Gly Asp 
        755                 760                 765             


Asn Val Ser Phe Ala Asp Ile Cys Lys Ile Leu Met Thr Asp Tyr Asn 
    770                 775                 780                 


Met Gln Asn Gln Glu Lys Lys Asn Ile Glu Ser Met Glu Gln Lys Lys 
785                 790                 795                 800 


Lys Asn Lys Gly Lys Asp Glu Asn Tyr Lys His Phe Pro Leu Leu Leu 
                805                 810                 815     


His Lys Val Leu Lys Glu Leu Phe Ile Glu Tyr Leu Lys Gln Thr His 
            820                 825                 830         


Glu Leu Glu Phe Leu Arg Asn Asn Ile Cys Ile Lys Ser Asp Val Thr 
        835                 840                 845             


Met Glu Ser Phe Glu Ser Gln Ile Lys Gly Val Glu Ile Tyr Lys Asp 
    850                 855                 860                 


Leu Lys Glu Lys Ile Asp Lys Asn Asn Ser Leu Leu Asp Trp Tyr Val 
865                 870                 875                 880 


Ile Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asn 
                885                 890                 895     


Ile Lys Asn Tyr Ile Gln Phe Ala Thr Asn Ile Asp Lys Arg Ala Glu 
            900                 905                 910         


Ser Val Lys Asn Leu Thr Glu Ser Gly Met Val Lys Arg Ile Gln Tyr 
        915                 920                 925             


Tyr Asp Asp Ile Val Arg Thr Leu Glu Phe Ser Ala Gln Tyr Ile Gly 
    930                 935                 940                 


Lys Ile Ser Asn Asn Ile Asn Asp Tyr Phe Asn Ser Glu Asp Glu Tyr 
945                 950                 955                 960 


Val Ser Phe Leu Ser Lys Tyr Val Gly Phe Ile Asn Asp Lys Ser Glu 
                965                 970                 975     


Asp Val Leu Thr Glu Leu Lys Asp Phe Cys Arg Glu Lys Ile Asn Asn 
            980                 985                 990         


Gly Ser Gln Ile Ile Gly Ile Tyr  Tyr Gly Gly Asp Asn  Val Ile Ile 
        995                 1000                 1005             


Asn Arg  Asn Val Ile Tyr Ala  Gln Met Tyr Ser Asn  Ala Glu Val 
    1010                 1015                 1020             


Phe Ser  Asn Ile Tyr Lys Lys  Val Thr Lys Asn Asp  Ile Ile Asn 
    1025                 1030                 1035             


Tyr Tyr  Glu Lys Gln Asn Asp  Leu Lys Asp Val Phe  Lys Ser Gly 
    1040                 1045                 1050             


Val Cys  Gln Asn Glu Asp Glu  Gln Arg Ser Leu Cys  Glu Phe Gln 
    1055                 1060                 1065             


Gln Leu  Lys Asn Arg Ile Glu  Leu Thr Glu Leu Ser  Thr Tyr Ala 
    1070                 1075                 1080             


Asp Met  Val Asn Asp Phe Met  Ala Gln Phe Val Glu  Trp Ala Tyr 
    1085                 1090                 1095             


Leu Arg  Glu Arg Asp Leu Met  Tyr Phe Gln Leu Gly  Ile His Tyr 
    1100                 1105                 1110             


Ile Arg  Leu Phe Tyr Ser Asp  Asn Val Leu Asp Glu  Lys Tyr His 
    1115                 1120                 1125             


Lys Leu  Ser Asp Asn Val Ile  Asp Ile Glu Glu Gly  Ala Leu Leu 
    1130                 1135                 1140             


Tyr Gln  Ile Val Ala Met Tyr  Asp Tyr Glu Leu Arg  Ile Phe Glu 
    1145                 1150                 1155             


Thr Asp  Asn Ser Gly Asn Ala  Lys Arg Ile Gly Gln  Gly Gly Pro 
    1160                 1165                 1170             


Gly Lys  Ser Ile Pro Val Phe  Leu Lys Lys Tyr Cys  Ser Gly Thr 
    1175                 1180                 1185             


Asp Val  Tyr Glu Cys Gly Leu  Glu Leu Phe Glu Asp  Ile Asn Gln 
    1190                 1195                 1200             


His Glu  His Ile Ile Arg Phe  Arg Asn Asp Ile Ala  His Met Arg 
    1205                 1210                 1215             


Tyr Met  Ser Asn Gln Ala Met  Asn Ile Met Ser Ile  Val Ser Asn 
    1220                 1225                 1230             


Ile Tyr  Lys Ser Phe Phe Ala  Tyr Asp Thr Lys Leu  Lys Lys Ser 
    1235                 1240                 1245             


Ile Ser  Leu Val Phe Lys Asn  Ile Leu Met Arg Tyr  Gly Val Ile 
    1250                 1255                 1260             


Ala Asp  Leu Val Phe Ser Tyr  Asn Asn Lys Asn Gln  Ser Ile Lys 
    1265                 1270                 1275             


Asp Asp  Met Asp Ile Asn Ile  Ile Asn Ile Lys Asn  Leu Lys Ser 
    1280                 1285                 1290             


Asp Lys  Tyr Val Tyr Lys Ile  Val Asn Glu Asp Ile  Val Lys Gln 
    1295                 1300                 1305             


Val Glu  Ile Glu Ile Arg Asn  Gln Val Phe Leu Glu  Gln Leu His 
    1310                 1315                 1320             


Asn Leu  Leu Tyr Phe Ser Arg  
    1325                 1330 


<210>  214
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  214

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Pro Gly Thr Asp Thr 
            20                  25                  30          


Ile Asp Leu Lys Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Lys Val Phe Asn Gln Ile Gln Val Gly Asn Lys Pro Lys Lys 
    50                  55                  60                  


Trp Lys Lys Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Glu Tyr Val Glu Ser Ser Gln Arg Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Glu Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Ser Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Met Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Tyr Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ser Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Lys Asp Arg Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Lys Glu Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Gln Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Phe 
            660                 665                 670         


Ile Arg Lys Asn Phe Pro Glu Asp Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Asp Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Asp Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asn  Ser Glu Lys Lys Glu  Ala Tyr Gln Lys Ile  Glu Val Asn 
    1100                 1105                 1110             


Gly Asp  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Val  Tyr Ala Pro Asp Glu  Lys Gly Asp 
    1130                 1135                 1140             


Ile Leu  Lys Glu Gln Cys Thr  Lys Gly Gly Ala Gly  Gly Lys Ile 
    1145                 1150                 1155             


Ser Ala  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Lys Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Lys Gln 
    1250                 1255                 1260             


Thr Thr  Ser Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Ser Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Lys  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Val Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Gly Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Pro Asn 
    1370                 1375                 1380         


<210>  215
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  215

Met Gly Ser Gly Lys Tyr Arg Ile Thr Lys Ile Gly Arg Asp Trp Asp 
1               5                   10                  15      


Glu Asn Lys Lys Arg Ile Ile Leu Lys Arg Val Val Ser Asn Gly Lys 
            20                  25                  30          


Val Lys Tyr Ile Asn Glu Asn Asp Asn Val Asp Val Asp Ile Thr Glu 
        35                  40                  45              


Thr Tyr Tyr Gly Ile Leu Ser Asn Asn Lys Ala Lys Phe Leu Gly Ser 
    50                  55                  60                  


Asn Glu Gln Phe Ile Phe Lys Val Asn Lys Met Lys Arg Asn Ile Lys 
65                  70                  75                  80  


Asn Asp Cys Val Ile Ile Lys Asp Tyr Thr Glu Glu Glu Phe Glu Lys 
                85                  90                  95      


Leu Asp Lys Lys Ile Phe Phe Ser Arg Lys Ile Lys Val Asn Asn Glu 
            100                 105                 110         


Asp Arg Glu Lys Ile Cys Arg Asn Phe Tyr Glu Asp Glu Arg Glu Ile 
        115                 120                 125             


Met Lys Lys Arg Phe Glu Glu Ala Lys Lys Phe Asn Asn Ile Ile Phe 
    130                 135                 140                 


Asn Ile Cys Asn Lys Ile Phe Lys Leu Glu Tyr Leu Asp Tyr Ile Asp 
145                 150                 155                 160 


Glu Lys Val Tyr Glu Ile Phe Gln Asn Glu Ile Lys Val Lys Asp Val 
                165                 170                 175     


Lys Asn Leu Lys Glu Ala Phe Lys Gln Gln Glu Lys Gly Leu Glu Thr 
            180                 185                 190         


Asp Lys Leu Leu Ala Ile Ser Phe Asn Lys Lys Arg Asn Asn Val Leu 
        195                 200                 205             


Leu Glu Phe Ile Gln Lys Ile Thr Lys Gln Glu Phe Lys Asn Gln Lys 
    210                 215                 220                 


Glu Leu Glu Asn Trp Phe Ser Gln Ser Gly Glu Lys Tyr Cys Lys Glu 
225                 230                 235                 240 


Ile Phe Lys Ile Tyr Ser Asn Met Ser Gln Lys Glu Lys Tyr Phe Lys 
                245                 250                 255     


Leu Leu Gly His Arg Asn Gln Gly Ile Ala Ser Ile Tyr Asp Glu Lys 
            260                 265                 270         


Lys Glu Thr Leu Gln Arg Arg Leu Lys Leu Gly Asp Tyr Ser Lys Tyr 
        275                 280                 285             


Asp Leu Lys Lys Tyr Tyr Gln Lys Asp Tyr Lys Glu Glu Ala Ile Lys 
    290                 295                 300                 


Glu Leu Lys Asp Lys Asn Lys Glu Glu Leu Glu Arg Glu Ile Glu Lys 
305                 310                 315                 320 


Leu Ile Lys Glu Asn Tyr Lys Ile Asp Glu Leu Cys Tyr Glu Ile Ser 
                325                 330                 335     


Asn Leu Glu Phe Ser Phe Val Asp Ser Lys Lys Glu Asn Lys Asp Lys 
            340                 345                 350         


Met Ser Glu Ile Ile Val Lys Ile Lys Glu His Tyr Lys Asn Asn Val 
        355                 360                 365             


Asn Ile Glu Glu Arg Leu Glu Asn Lys Glu Lys Tyr Ile Leu Ser Met 
    370                 375                 380                 


Ile His Asn Tyr Val Lys Gly Arg Tyr Arg Lys Cys Leu Glu Leu Gln 
385                 390                 395                 400 


Gln Lys Glu Asn Val Asp Leu Glu Asn Leu Gly Lys Arg Ile Lys Glu 
                405                 410                 415     


Ile Phe Asp Ser Asn Gln Val Thr Lys Lys Leu Lys Lys Ser Ile Leu 
            420                 425                 430         


Asn Lys Val Asn Asn Tyr Lys Ile Phe Glu Thr Lys Phe Gln Asn Pro 
        435                 440                 445             


Asn Ile Glu Ser Ser Asp Asp Leu Glu Ile Leu Lys Ala Glu Glu Thr 
    450                 455                 460                 


Phe Leu Asn Lys Leu Ser Thr Ala Val Ser Lys Val Gly Tyr Thr Leu 
465                 470                 475                 480 


Asn Thr Leu Leu Glu Val Ser Pro Glu Lys Asp Ile Leu Glu Asn Tyr 
                485                 490                 495     


Asn Met Val Val Glu Leu Cys Asn Asn Asn Ser Thr Thr Glu Ile Tyr 
            500                 505                 510         


Lys Val Tyr Pro Glu Leu Glu Lys Asn Glu Lys Leu Leu Gln Gly Met 
        515                 520                 525             


Ile His Phe Ile Gln Gly Ile Arg Gln Gln Ser Leu His Pro Lys Ile 
    530                 535                 540                 


Ser Trp Asn Phe Glu Thr Lys Asn Leu Lys Pro Glu Lys Leu Glu Arg 
545                 550                 555                 560 


Leu Lys Glu Lys Lys Asn Ile Lys Met Arg Asp Cys Val Val His Glu 
                565                 570                 575     


Asp Asn Leu Asp Lys Lys Glu Lys Ser Glu Val Glu Ile Lys Arg Tyr 
            580                 585                 590         


Phe Glu Lys Ile Glu Glu Lys Leu Pro Asp Tyr Phe Ile Glu Lys Tyr 
        595                 600                 605             


Glu Ser Asn Asn Val Phe Asn Ile Tyr Arg Asn Phe Val Asp Lys Ile 
    610                 615                 620                 


Met Glu Ala Val Lys Asn Phe Asn Phe Lys Glu Asn Asn Thr Ile Asp 
625                 630                 635                 640 


Tyr Leu Phe Pro Lys Phe His Lys Ile Tyr Lys Arg Met Tyr Lys Ser 
                645                 650                 655     


Glu Asn Ile Asp Asp Arg Gln Asn Gly Ala Arg Lys Tyr Leu Leu Gln 
            660                 665                 670         


Thr Ile Tyr Tyr Tyr Tyr Phe Gln Tyr Lys Ile Glu Asn Asp Lys Asn 
        675                 680                 685             


Asp Ile Phe Lys Tyr Leu Asn Leu Tyr Lys Asn Lys Ile Lys Ala Lys 
    690                 695                 700                 


Lys Ile Ser Tyr Ser Tyr Ile Ile Asp Asn Lys Asn Val Asn Asn Lys 
705                 710                 715                 720 


Asn Ile Glu Ile Leu Tyr Arg Asn Ile Gln Arg Glu Gly Met Leu Asn 
                725                 730                 735     


Asn Arg Leu Ser Gln Met Asn Asn Glu Trp Ile Glu Phe Ile Val Val 
            740                 745                 750         


Gln Phe Ser Glu Phe Leu Thr Asn Lys Lys Leu Asn Trp Ile Leu Asp 
        755                 760                 765             


Asp Leu Ser Glu Tyr Lys Lys Lys Glu Lys Leu Asp Glu Asn Asn Lys 
    770                 775                 780                 


Asn Lys Leu Leu Lys Ile Leu Lys Gln Lys Met Asn Lys Lys Ile Ile 
785                 790                 795                 800 


Tyr Ser Asn Asp Ser Tyr Val Phe Ile Ser Leu Ala Gln Phe Leu Asp 
                805                 810                 815     


Leu Lys Glu Ile Ser Asn Leu Ile His Asp Ile Lys Lys Phe Val Gln 
            820                 825                 830         


Phe Arg Glu Lys Asn Ala Ser Lys Tyr Lys Pro Glu Lys Asn Glu Leu 
        835                 840                 845             


Tyr Ile Glu Glu Leu Lys Lys Val Leu Tyr Ile Leu Lys Val Met Leu 
    850                 855                 860                 


Glu His Lys Glu Arg Val Ile Gln Lys His Tyr Leu Glu Ser Tyr Asp 
865                 870                 875                 880 


Glu Asp Ile Ser Ile Ile Tyr Gly Lys Glu Ile Glu Lys Lys Asp Ile 
                885                 890                 895     


Lys Asp Ile Glu Ile Glu Ile Lys Ile Lys Asn Glu Asn Gln Glu Val 
            900                 905                 910         


Asn Gln Glu Val Ile Val Ile Asn Gln Pro Leu Tyr Lys Ser Gly Asp 
        915                 920                 925             


Asp Glu Asn Ser Ser Trp Ile Ile Leu Tyr Gly Ile Glu Gln Ala Lys 
    930                 935                 940                 


Arg Asn Gly Thr Phe Lys Phe Phe Glu Gly Phe Phe Asn Leu Asn Asp 
945                 950                 955                 960 


Asp Ile Lys Leu Cys Lys Glu Asn Ile Lys Lys Tyr Glu Glu Leu Tyr 
                965                 970                 975     


Asn Lys Arg Lys Glu Asn Gln Ile Lys Val Asp Glu Tyr Ile Ser Ser 
            980                 985                 990         


Glu Glu Asn Asn Asn Ile Asp Glu  Ile Lys Glu Ile Asn  Asn Asn Lys 
        995                 1000                 1005             


Gln Leu  Phe Tyr Tyr Tyr Lys  Asn Met Ile Tyr Gly  Asp Gly Leu 
    1010                 1015                 1020             


Lys Lys  Gly Tyr Asp Phe Ile  Asn Asp Ile Tyr Ser  His Tyr Leu 
    1025                 1030                 1035             


Ser Trp  Ala Tyr Arg Ile Glu  Arg Asp Tyr Ser Ile  Tyr Lys Val 
    1040                 1045                 1050             


Lys Ile  Tyr Asn Gly Lys Ile  Lys Asn Phe Arg Asn  Glu Ile Ala 
    1055                 1060                 1065             


His Phe  Asn Tyr Phe Gln Lys  Thr Asn Lys Ser Leu  Leu Glu Leu 
    1070                 1075                 1080             


Leu Asn  Asp Phe Tyr Asp Ile  Phe Asp Tyr Asn Leu  Lys Tyr Gln 
    1085                 1090                 1095             


Arg Asp  Val Gln Asn Val Ile  Asn Asn Ile Phe Glu  Lys Tyr Gln 
    1100                 1105                 1110             


Ile Val  Arg Lys Asp Gly Gly  Pro Val Val Phe Tyr  Cys Lys Thr 
    1115                 1120                 1125             


Asp Lys  Lys Leu Lys Leu Ser  Glu Asn Leu Val Pro  Lys Lys His 
    1130                 1135                 1140             


Ser Lys  Tyr Pro Glu Ile Lys  Leu Ile His Glu Lys  Tyr Val Met 
    1145                 1150                 1155             


Phe Phe  Arg Lys Leu Phe Glu  Tyr Lys Lys 
    1160                 1165             


<210>  216
<211>  1050
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  216

Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu Leu Glu Ile Phe Arg Lys 
1               5                   10                  15      


Asp Val Glu Ala Lys Leu Asn Lys Ile Asn Ser Leu Lys Tyr Ser Phe 
            20                  25                  30          


Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile Asn Glu Asn Asn Val Glu 
        35                  40                  45              


Lys Val Gly Gly Lys Ser Lys Arg Asn Ile Ile Tyr Asp Tyr Tyr Arg 
    50                  55                  60                  


Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn Asn Val Gln Glu Ala Phe 
65                  70                  75                  80  


Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu Asn Leu Phe Phe Leu Ile 
                85                  90                  95      


Glu Asn Ser Lys Lys His Glu Lys Tyr Lys Ile Arg Glu Tyr Tyr His 
            100                 105                 110         


Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu Asn Phe Ala Lys Ile Ile 
        115                 120                 125             


Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile Lys Glu Leu Ile Glu Lys 
    130                 135                 140                 


Val Pro Asp Met Ser Glu Leu Lys Lys Ser Gln Val Phe Tyr Lys Tyr 
145                 150                 155                 160 


Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys Asn Ile Lys Tyr Ala Phe 
                165                 170                 175     


Cys His Phe Val Glu Ile Glu Met Ser Lys Leu Leu Lys Asn Tyr Val 
            180                 185                 190         


Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp Lys Val Lys Arg Ile Phe 
        195                 200                 205             


Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu Asn Lys Leu Leu Asn Lys 
    210                 215                 220                 


Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys Tyr Asn Tyr Tyr Leu Gln 
225                 230                 235                 240 


Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile Ala Arg Asn Arg Gln Asn 
                245                 250                 255     


Glu Ala Phe Leu Arg Asn Ile Ile Gly Val Ser Ser Val Ala Tyr Phe 
            260                 265                 270         


Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn Glu Asn Asp Ile Thr Gly 
        275                 280                 285             


Arg Met Arg Gly Lys Thr Val Lys Asn Asn Lys Gly Glu Glu Lys Tyr 
    290                 295                 300                 


Val Ser Gly Glu Val Asp Lys Ile Tyr Asn Glu Asn Lys Gln Asn Glu 
305                 310                 315                 320 


Val Lys Glu Asn Leu Lys Met Phe Tyr Ser Tyr Asp Phe Asn Met Asp 
                325                 330                 335     


Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala Asn Ile Asp Glu Ala Ile 
            340                 345                 350         


Ser Ser Ile Arg His Gly Ile Val His Phe Asn Leu Glu Leu Glu Gly 
        355                 360                 365             


Lys Asp Ile Phe Ala Phe Lys Asn Ile Val Pro Ser Glu Ile Ser Lys 
    370                 375                 380                 


Lys Met Phe Gln Asn Glu Ile Asn Glu Lys Lys Leu Lys Leu Lys Ile 
385                 390                 395                 400 


Phe Arg Gln Leu Asn Ser Ala Asn Val Phe Arg Tyr Leu Glu Lys Tyr 
                405                 410                 415     


Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg Phe Glu Phe Val Asn Lys 
            420                 425                 430         


Asn Ile Pro Phe Val Pro Ser Phe Thr Lys Leu Tyr Ser Arg Ile Asp 
        435                 440                 445             


Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp Lys Thr Pro Lys Thr Asn 
    450                 455                 460                 


Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp Ala Gln Ile Tyr Leu Leu 
465                 470                 475                 480 


Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn Tyr Phe Met Ser Asn Asn 
                485                 490                 495     


Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile Ile Glu Leu Asn Lys Asn 
            500                 505                 510         


Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr Lys Leu Gln Lys Phe Glu 
        515                 520                 525             


Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr Leu Ala Asn Ile Gln Ser 
    530                 535                 540                 


Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp Glu Glu Glu Lys Asp Thr 
545                 550                 555                 560 


Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu Lys Gly Phe Met Thr Tyr 
                565                 570                 575     


Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile Tyr Ile Gly Ser Asp Glu 
            580                 585                 590         


Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys Gln Glu Phe Asp Lys Phe 
        595                 600                 605             


Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile Lys Ile Pro Tyr Glu Ile 
    610                 615                 620                 


Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly Asn Ile Leu Lys Tyr Thr 
625                 630                 635                 640 


Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu Lys Leu Leu Asn His Lys 
                645                 650                 655     


Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu Lys Tyr Gln Ser Ala Asn 
            660                 665                 670         


Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu Leu Ile Asn Leu Leu Asn 
        675                 680                 685             


Leu Asp Asn Asn Arg Val Thr Glu Asp Phe Glu Leu Glu Ala Asp Glu 
    690                 695                 700                 


Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn Lys Ile Lys Asp Arg Lys 
705                 710                 715                 720 


Glu Leu Lys Lys Phe Asp Thr Lys Lys Ile Tyr Phe Asp Gly Glu Asn 
                725                 730                 735     


Ile Ile Lys His Arg Ala Phe Tyr Asn Ile Lys Lys Tyr Gly Met Leu 
            740                 745                 750         


Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala Lys Tyr Lys Ile Ser Ile 
        755                 760                 765             


Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys Asn Glu Ile Glu Lys Asn 
    770                 775                 780                 


His Thr Thr Gln Glu Asn Leu His Arg Lys Tyr Ala Arg Pro Arg Lys 
785                 790                 795                 800 


Asp Glu Lys Phe Thr Asp Glu Asp Tyr Lys Glu Tyr Glu Lys Ala Ile 
                805                 810                 815     


Gly Asn Ile Gln Lys Tyr Thr His Leu Lys Asn Lys Val Glu Phe Asn 
            820                 825                 830         


Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu Lys Ile Leu His Arg Leu 
        835                 840                 845             


Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp Leu Arg Phe Arg Leu Lys 
    850                 855                 860                 


Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu Glu Ile Phe Asn Phe Asp 
865                 870                 875                 880 


Asn Ser Lys Asn Val Lys Tyr Lys Ser Gly Gln Ile Val Glu Lys Tyr 
                885                 890                 895     


Ile Asn Phe Tyr Lys Glu Leu Tyr Lys Asp Asn Val Glu Lys Arg Ser 
            900                 905                 910         


Ile Tyr Ser Asp Lys Lys Val Lys Lys Leu Lys Gln Glu Lys Lys Asp 
        915                 920                 925             


Leu Tyr Ile Arg Asn Tyr Ile Ala His Phe Asn Tyr Ile Pro His Ala 
    930                 935                 940                 


Glu Ile Ser Leu Leu Glu Val Leu Glu Asn Leu Arg Lys Leu Leu Ser 
945                 950                 955                 960 


Tyr Asp Arg Lys Ile Lys Asn Ala Val Met Lys Ser Val Val Asp Ile 
                965                 970                 975     


Leu Lys Glu Tyr Gly Phe Val Val Lys Phe Lys Ile Gly Ala Asp Lys 
            980                 985                 990         


Lys Ile Glu Ile Gln Ser Leu Lys  Ser Glu Glu Ile Val  His Leu Lys 
        995                 1000                 1005             


Lys Leu  Lys Leu Lys Asp Asn  Asp Lys Lys Lys Glu  Pro Ile Lys 
    1010                 1015                 1020             


Thr Tyr  Arg Asn Ser Lys Glu  Leu Cys Lys Leu Val  Lys Val Met 
    1025                 1030                 1035             


Phe Glu  Tyr Lys Met Glu Glu  Lys Ser Ser Glu Lys  
    1040                 1045                 1050 


<210>  217
<211>  1380
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  217

Met Lys Leu Ser Lys Glu Lys Gln Ile Arg Ser Ala Val Ala Asn Lys 
1               5                   10                  15      


Glu Lys Asn Thr Glu Gly Val Leu Tyr Arg Phe Pro Gly Asp Asp Ile 
            20                  25                  30          


Gly Gly Val Gln Ala Gln Met Leu Val Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Leu Gly Asn Lys Pro Lys Glu 
    50                  55                  60                  


Trp Met Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Lys Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Ala Ile Asn Asp Ile Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Lys Glu Ala Asp Lys Lys Ile Arg Asn Met Ser Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Asn Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Ser Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Gly Asn Gln Glu Phe Asp Ser Ile Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Asp Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Ser Ile Gln Asp Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Ile Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Glu Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Asp Gly Leu Asn Glu Phe Met Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Glu Glu Lys Arg Ala Glu Val Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Ser His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Val Asn Lys Gly Lys Phe Tyr Val Trp 
305                 310                 315                 320 


Lys Lys His Glu Cys Gly Lys Lys Glu Asn Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Val Glu Ala Glu Ala Glu Ser Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Ile Phe Phe Glu Asn Asp Thr Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Thr Gly Thr Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Lys Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asn Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Gln Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Leu 
            660                 665                 670         


Val Arg Thr Val Phe Pro Glu Tyr Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Asn Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Arg Thr Leu Arg Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Lys 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Glu Asn Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Cys Ala Gln Asp 
            900                 905                 910         


Ile Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu 
        915                 920                 925             


Leu Ser Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Lys Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Lys Phe Ser Glu Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Thr Asn Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Gly  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Glu Lys Pro Glu  Glu Tyr Glu Lys Ile  Glu Ala Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Ile  Tyr Ala Pro Glu Lys  Asn Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Gln Gly Arg Val Gly  Ala Lys Val 
    1145                 1150                 1155             


Thr Ser  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Glu Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Met Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Val Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Val Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Glu Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asn Ala 
    1280                 1285                 1290             


Lys Asp  Lys Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Asp  Ala Glu Asp Ala Asp  Ser Lys Lys Pro Val  Ile Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Glu  Asp Glu Asp 
    1325                 1330                 1335             


Lys Gln  Lys Gly Lys Glu Asn  Arg Gly Lys Lys Asn  Thr Glu Thr 
    1340                 1345                 1350             


Arg Ser  Asp Ala Glu Lys Asn  Asn Asn Glu Arg Leu  Ser Tyr Asn 
    1355                 1360                 1365             


Pro Phe  Ala Asn Phe Asp Phe  Lys Leu Pro Asn Lys  
    1370                 1375                 1380 


<210>  218
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  218

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Glu 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Met Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro Tyr Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Ala Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Thr Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Glu Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Lys  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  219
<211>  1384
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  219

Met Gly Asn Leu Phe Gly His Lys Arg Trp Tyr Glu Val Ser Asp Arg 
1               5                   10                  15      


Glu Asn Tyr Lys Ile Lys Arg Lys Val Lys Val Lys Arg Asn Tyr Asp 
            20                  25                  30          


Gly Asn Lys Tyr Ile Leu Asn Ile Asn Glu Asn Asn Asn Lys Glu Lys 
        35                  40                  45              


Ile Asp Asn Asn Glu Phe Ile Glu Glu Leu Val Asn Tyr Lys Lys Asn 
    50                  55                  60                  


Asn Asn Val Leu Arg Glu Phe Lys Arg Lys Phe His Ala Arg Asn Ile 
65                  70                  75                  80  


Leu Phe Lys Leu Lys Gly Asn Lys Arg Ser Ile Glu Asp Ser Asn Asp 
                85                  90                  95      


Phe Leu Lys Thr Glu Glu Val Val Leu Asp Lys Glu Ile Tyr Gly Gln 
            100                 105                 110         


Ser Glu Lys Leu Arg Asn Glu Lys Gly Ile Thr Lys Lys Asp Ile Leu 
        115                 120                 125             


Lys Glu Ile Asn Lys Gln Lys Ile Asp Asn Ser Val Lys Lys Ile Ser 
    130                 135                 140                 


Met Asn Thr Asn Ser Gly Lys Thr Ile Val Ile Asn Phe Ser Asp Lys 
145                 150                 155                 160 


Leu Lys Lys Asp Lys Asp Asp Tyr Gln Ile Thr Leu Asn Ile Ile Ser 
                165                 170                 175     


Glu Asp Glu Leu Glu Arg Lys Arg Lys Ile Tyr Asp Ile Phe Lys Met 
            180                 185                 190         


Ile Asn Met Asp Leu Tyr Gln Ile Ile Lys Glu Ile Ile Glu Asn Gln 
        195                 200                 205             


Val Gln Lys Val Phe Lys Asn Arg Tyr Tyr Glu Glu His Leu Arg Glu 
    210                 215                 220                 


Lys Leu Leu Lys Asp Asp Lys Met Asp Val Ile Leu Thr Asn Phe Met 
225                 230                 235                 240 


Lys Ile Arg Glu Lys Ile Glu Ser Asn Pro Glu Ile Met Gly Phe Val 
                245                 250                 255     


Lys Phe Tyr Leu Asn Val Gly Gly Asp Lys Lys Lys Ser Glu Asn Lys 
            260                 265                 270         


Lys Met Phe Val Glu Lys Ile Leu Asn Ile Asn Val Asp Leu Thr Val 
        275                 280                 285             


Glu Asp Ile Val Asp Phe Ile Val Lys Glu Leu Lys Phe Trp Asn Ile 
    290                 295                 300                 


Thr Lys Arg Ile Glu Lys Val Lys Glu Phe Asn Asn Lys Phe Leu Glu 
305                 310                 315                 320 


Asn Lys Arg Asn Arg Thr Tyr Ile Lys Ser Tyr Val Leu Leu Asp Lys 
                325                 330                 335     


His Glu Lys Phe Lys Ile Glu Arg Glu Asn Lys Lys Asp Lys Ile Val 
            340                 345                 350         


Lys Phe Phe Val Glu Asn Ile Lys Asn Asn Ser Ile Lys Glu Lys Ile 
        355                 360                 365             


Glu Lys Ile Leu Ala Glu Phe Lys Ile Asp Glu Leu Thr Lys Lys Leu 
    370                 375                 380                 


Glu Lys Gly Asn Cys Asp Thr Glu Ile Phe Gly Ile Phe Lys Lys His 
385                 390                 395                 400 


Tyr Lys Val Asn Phe Asp Ser Lys Lys Phe Glu Asn Lys Ser Asp Glu 
                405                 410                 415     


Glu Lys Glu Leu Tyr Lys Ile Ile Tyr Arg Tyr Leu Lys Gly Arg Ile 
            420                 425                 430         


Glu Lys Ile Leu Ile Asn Glu Glu Lys Val Arg Leu Lys Lys Met Glu 
        435                 440                 445             


Lys Ile Glu Ile Glu Lys Ile Leu Asn Glu Ser Ile Leu Ser Glu Lys 
    450                 455                 460                 


Ile Leu Lys Arg Val Lys Gln Tyr Thr Leu Glu His Ile Met Tyr Leu 
465                 470                 475                 480 


Gly Lys Leu Val His Asn Lys Ile Asn Met Ala Thr Val Asn Thr Asn 
                485                 490                 495     


Asp Phe Phe Arg Leu His Ala Lys Glu Glu Leu Asp Leu Glu Leu Ile 
            500                 505                 510         


Thr Phe Leu Ala Ser Thr Asn Met Glu Leu Asn Lys Ile Phe Asn Gly 
        515                 520                 525             


Lys Glu Lys Val Thr Asp Phe Phe Gly Phe Asn Leu Asn Gly Gln Lys 
    530                 535                 540                 


Ile Thr Leu Lys Glu Lys Val Pro Ser Phe Lys Leu Asn Ile Leu Lys 
545                 550                 555                 560 


Lys Leu Asn Phe Ile Asn Asn Glu Asn Asn Ile Asp Glu Lys Leu Ser 
                565                 570                 575     


His Phe Tyr Ser Phe Gln Lys Lys Gly Tyr Leu Leu Arg Asn Lys Ile 
            580                 585                 590         


Leu His Asn Ser Tyr Gly Asn Ile Gln Glu Thr Ile Asn Leu Lys Gly 
        595                 600                 605             


Glu Tyr Glu Asn Val Glu Asn Leu Ile Lys Glu Leu Lys Val Ser Asn 
    610                 615                 620                 


Glu Glu Ile Ser Lys Ser Leu Asn Leu Asp Ile Ile Phe Glu Gly Lys 
625                 630                 635                 640 


Val Asp Ile Ile Asn Lys Ile Asn Ser Leu Glu Ile Gly Glu Tyr Lys 
                645                 650                 655     


Asp Lys Lys Tyr Leu Pro Ser Phe Ser Lys Ile Val Pro Glu Ile Met 
            660                 665                 670         


Arg Lys Phe Arg Glu Ile Asn Lys Asp Lys Ser Phe Asp Ile Glu Ser 
        675                 680                 685             


Glu Lys Ile Ile Leu Asn Ala Val Gln Tyr Val Asn Lys Ile Leu Tyr 
    690                 695                 700                 


Glu Lys Ile Thr Ser Asn Glu Glu Asn Glu Phe Ile Lys Thr Leu Pro 
705                 710                 715                 720 


Asp Lys Leu Val Lys Lys Asn Asn Asn Lys Glu Asn Asn Asn Ser Leu 
                725                 730                 735     


Ser Ile Glu Glu Tyr Tyr Lys Asn Ala Gln Ile Ser Ser Ser Lys Gly 
            740                 745                 750         


Asp Lys Lys Ala Ile Lys Lys Tyr Gln Asn Lys Val Thr Asn Ala Tyr 
        755                 760                 765             


Ile Glu Tyr Leu Glu Asn Thr Phe Ala Glu Val Ile Asp Phe Ser Asn 
    770                 775                 780                 


Phe Asn Leu Asn Phe Asp Glu Ile Lys Thr Lys Ile Glu Glu Arg Lys 
785                 790                 795                 800 


Tyr Ser Lys Ser Lys Ile Thr Val Asp Ser Ile Ser Thr Asn Ile Asn 
                805                 810                 815     


Ile Thr Asn Asp Ile Glu Tyr Ile Ile Ser Ile Phe Ala Leu Leu Asn 
            820                 825                 830         


Ser Asn Thr Tyr Ile Asn Lys Ile Arg Asn Arg Phe Phe Ala Thr Ser 
        835                 840                 845             


Val Trp Leu Asp Lys Gln Asn Ser Thr Lys Glu Tyr Asp Tyr Glu Asn 
    850                 855                 860                 


Ile Ile Asp Ile Leu Asp Lys Ile Leu Ser Ile Asn Leu Leu Arg Glu 
865                 870                 875                 880 


Asn Asn Ile Ala Asp Ile Leu Asp Leu Lys Asn Thr Ile Ile Glu Ala 
                885                 890                 895     


Lys Ile Val Glu Asn Asn Glu Glu Cys Ile Lys Asn Tyr Ile Phe Glu 
            900                 905                 910         


Asn Asn Glu Glu Glu Leu Lys Lys Arg Leu Phe Cys Glu Glu Leu Val 
        915                 920                 925             


Asn Lys Glu Asp Val Leu Lys Ile Phe Glu Asp Lys Asn Phe Lys Phe 
    930                 935                 940                 


Lys Asn Phe Ile Lys Lys Thr Gly Asn Glu Asn Phe Thr Ile Asn Phe 
945                 950                 955                 960 


Asp Ile Leu Phe Asn Leu Glu Cys Asn Ser Glu Leu Asn Val Lys Lys 
                965                 970                 975     


Val Met Gly Gln Asn Ser Gln Arg Leu Asn Leu Phe Ile Lys Asn Thr 
            980                 985                 990         


Ile Asp Glu Tyr Lys Ser Lys Ile  Lys Thr Ser Phe Ser  Ser Glu Phe 
        995                 1000                 1005             


Leu Glu  Lys Tyr Lys Lys Glu  Ile Asp Asn Leu Val  Glu Asp Thr 
    1010                 1015                 1020             


Glu Ser  Glu Asn Lys Asn Lys  Phe Glu Lys Ile Tyr  Tyr Pro Lys 
    1025                 1030                 1035             


Glu His  Lys Asn Glu Leu Tyr  Ile Tyr Lys Lys Asn  Leu Phe Leu 
    1040                 1045                 1050             


Asn Ile  Gly Asn Pro Asn Phe  Asp Lys Ile Tyr Glu  Leu Ile Ser 
    1055                 1060                 1065             


Lys Asp  Ile Lys Asn Ala Asn  Thr Glu Ile Leu Phe  Asp Asp Asp 
    1070                 1075                 1080             


Ile Arg  Lys Asn Lys Ile Ser  Glu Ile Asp Ala Ile  Leu Lys Asn 
    1085                 1090                 1095             


Leu Asn  Asp Lys Leu Asn Gly  Tyr Ser Asn Asp Tyr  Lys Ala Lys 
    1100                 1105                 1110             


Tyr Val  Asn Lys Leu Lys Glu  Asn Asp Asp Phe Phe  Ala Lys Asn 
    1115                 1120                 1125             


Met Lys  Asn Glu Asn Tyr Ser  Ser Phe Gly Glu Phe  Glu Lys Asp 
    1130                 1135                 1140             


Tyr Asn  Lys Val Ser Glu Tyr  Lys Lys Ile Arg Asp  Leu Val Glu 
    1145                 1150                 1155             


Phe Asn  Tyr Leu Asn Lys Ile  Glu Ser Tyr Leu Ile  Asp Ile Asn 
    1160                 1165                 1170             


Trp Lys  Leu Ala Ile Gln Met  Ala Arg Phe Glu Arg  Asp Met His 
    1175                 1180                 1185             


Tyr Ile  Val Asn Gly Leu Arg  Glu Leu Gly Ile Ile  Lys Leu Ser 
    1190                 1195                 1200             


Gly Tyr  Asn Thr Gly Ile Ser  Arg Ala Tyr Pro Lys  Arg Asn Gly 
    1205                 1210                 1215             


Ser Asp  Gly Phe Tyr Thr Thr  Thr Ala Tyr Tyr Lys  Phe Phe Asp 
    1220                 1225                 1230             


Glu Glu  Ser Tyr Lys Lys Phe  Glu Lys Ile Cys Tyr  Gly Phe Gly 
    1235                 1240                 1245             


Ile Asp  Leu Ser Glu Asn Ser  Glu Ile Asn Lys Pro  Glu Asn Glu 
    1250                 1255                 1260             


Ser Ile  Arg Asn Tyr Ile Ser  His Phe Tyr Ile Val  Arg Asn Pro 
    1265                 1270                 1275             


Phe Val  Asp Tyr Ser Ile Ala  Glu Gln Ile Asp Arg  Val Ser Asn 
    1280                 1285                 1290             


Leu Leu  Ser Tyr Ser Thr Arg  Tyr Asn Asn Ser Thr  Tyr Ala Ser 
    1295                 1300                 1305             


Val Phe  Glu Val Phe Lys Lys  Asp Val Asn Leu Asp  Tyr Asp Lys 
    1310                 1315                 1320             


Leu Lys  Thr Lys Phe Lys Leu  Phe Asp Asp Glu Lys  Asn Asp Asn 
    1325                 1330                 1335             


Ile Lys  Ile Leu Lys Ile Glu  Asn Leu Ile Glu Ser  Lys Lys Val 
    1340                 1345                 1350             


Ser Val  Leu Glu Leu Glu Ser  Tyr Asn Ser Asp Tyr  Ile Lys Asn 
    1355                 1360                 1365             


Leu Ile  Ile Glu Leu Leu Thr  Lys Ile Glu Asn Thr  Asn Asp Thr 
    1370                 1375                 1380             


Leu 
    


<210>  220
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  220

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  221
<211>  1423
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  221

Met Arg Ile Leu Arg Ser Lys Gly Thr Ser Tyr Thr Arg Phe Glu Gly 
1               5                   10                  15      


Arg Arg Gln Ser His Lys Asp Leu Ser Asp Pro Ala His Glu Lys Asp 
            20                  25                  30          


Pro Ser Leu Arg Gln Leu Pro Ser Arg Gly Leu Leu Leu Lys Thr Lys 
        35                  40                  45              


Ala Ala Ser Ser Gly Gly Ala Arg Ser Leu Ser Glu Lys Ile Trp Asp 
    50                  55                  60                  


Ser Arg Ser Leu Pro Asp Gln Leu Glu Arg Asp Arg Asp Leu Ala Leu 
65                  70                  75                  80  


Arg Gln Tyr Ile Gln Trp Leu Asp Lys Ala Leu Lys Lys Pro Arg Asn 
                85                  90                  95      


Leu Arg Leu Leu Asp Met Pro Ser Tyr Val Ala Arg Thr His Leu Gly 
            100                 105                 110         


Thr Cys Leu Trp Asp Leu Phe Ala Glu Leu Gln Phe Glu Asp Ser Thr 
        115                 120                 125             


Pro Asp Asp Pro Ile Tyr Lys Gln Tyr Leu Thr Arg Trp Gln Thr Lys 
    130                 135                 140                 


Val His Pro Tyr Ala Arg His Glu Val Asn Trp Gln Lys Pro Glu Thr 
145                 150                 155                 160 


Asp Gly Asn Ala Glu Glu Ile Asn Gln Thr Gln Gly Thr Pro Cys Lys 
                165                 170                 175     


Glu Pro Asp Leu Ala Met Ser Thr Thr Arg Trp Thr Ser Val Phe Gly 
            180                 185                 190         


Val Pro Val Gly Ala Ser Thr Met Asp Ala Tyr Arg Glu Ala Ala Ser 
        195                 200                 205             


Lys Ile His Glu His Leu Leu Phe Gln Glu Leu Thr Ile Gln Gly Asp 
    210                 215                 220                 


Glu Arg Glu Ser Gln Arg His Pro Ser Gly Tyr Gly Phe Met Asn Lys 
225                 230                 235                 240 


Arg Gly Glu Ile Ile Thr Leu Asp Ala Thr Asp Pro Arg Asp Cys Asp 
                245                 250                 255     


Arg Phe Glu Arg Tyr Lys Asn Trp Ser Glu Glu Leu Glu Glu Leu Tyr 
            260                 265                 270         


Phe Gln Tyr Gly Asp Val Ala Arg Gln Ile Ala Ser Gly Phe Lys Asn 
        275                 280                 285             


Glu Pro Lys Ala Gly Lys Pro Lys Gln Arg Ile Gly Ala Ala Leu Tyr 
    290                 295                 300                 


Glu His Phe Gly Lys Val Leu Gln Asp Ser Lys Ile Pro Asp Glu Lys 
305                 310                 315                 320 


Arg Gln Glu Leu Trp Asn Leu His Asn Arg Ile Arg His Phe Tyr Arg 
                325                 330                 335     


Thr Leu Ala Gly Ser Arg Arg Leu Leu Glu Ala Leu Arg Ser Asp Asp 
            340                 345                 350         


Thr Asn Lys Leu Arg Phe Leu Leu Pro Lys Asn Ser Glu Glu Leu Leu 
        355                 360                 365             


Asp Arg Val Val Gly Lys Arg Asn Ala Ser Arg Leu Asn Arg Lys Val 
    370                 375                 380                 


Arg Leu Gly Lys Ile Ile Ala His Ser Ile Asp Leu Ser Ala Gly Tyr 
385                 390                 395                 400 


Gly Gly Ser Asn Phe Asn Ala Leu Val His Glu Ala Met Asn Tyr Tyr 
                405                 410                 415     


Thr Thr Ser Val Gly Gln Ser Asp Ile Lys Arg Asn Glu Ala Phe Val 
            420                 425                 430         


Arg Ile Leu Arg Asn Ala Val Ala Phe Ser Met Arg Thr His Ala Thr 
        435                 440                 445             


Trp Leu Glu Glu Gly Leu Asp Gln Gln Ala Lys Ala Phe Gly Thr Gly 
    450                 455                 460                 


Asp Arg Pro Val Ala Ser Lys Glu Ala Ser Arg Asp Leu Ser Glu Arg 
465                 470                 475                 480 


Asp Thr Ala Ala Gly Ala Leu Leu His Thr Pro Leu His Lys Ile Ile 
                485                 490                 495     


Pro His Ala Arg Leu Ile Phe Gly Ser Arg Val Tyr Glu Phe Ala Phe 
            500                 505                 510         


Asp Ser Thr Ser Val Gln Glu Ala Arg Lys Ser Arg Ser Arg Thr Asp 
        515                 520                 525             


Val Leu Phe Asp Gly Ser Glu Gln Asp Lys Glu Val Leu Trp Gly Leu 
    530                 535                 540                 


Leu Arg Leu Ala Ala Leu Val Arg Asn Arg Ser Tyr His Phe Asn Thr 
545                 550                 555                 560 


Lys Lys Arg Phe Leu Ser Ala Leu Glu Asn Gly Leu Leu Arg Ala Pro 
                565                 570                 575     


Ala Asn Lys Gly Asp Arg Lys Pro Phe Ser Asp Arg Asp Gly Ser Ile 
            580                 585                 590         


Val Asp Ser Pro Ala Leu Met Arg Leu Glu Ser Leu Leu Asp Tyr Asp 
        595                 600                 605             


Leu Lys Leu Asp Ala Gln Ile Leu Ser Gln Thr Leu Thr Ala Leu Arg 
    610                 615                 620                 


Phe His His His Val Pro Thr Glu Met Arg Ser Ala Asn Leu Leu Thr 
625                 630                 635                 640 


Leu Gly Arg Leu Pro Ala Ser Asp Asp Arg Val Thr Pro Lys Phe Met 
                645                 650                 655     


Thr Leu Ile Gln Lys Gly Lys Asp Leu Ala Ser Asn Asp Ala Ala Asp 
            660                 665                 670         


Leu Val Pro Asp Leu Leu Gln Gln Phe Ser Ala Leu Gln Leu His Asp 
        675                 680                 685             


Leu Ser Lys Asp His Gly Ser Val Asn His Asp Arg Ile Gly Ile Leu 
    690                 695                 700                 


Arg Leu Leu Tyr Asn Arg Ala Phe Pro Asn Trp Leu Glu Gln Ile Glu 
705                 710                 715                 720 


Lys Ser Glu Glu Ala Ser Val Lys Val Phe Lys Glu Ile Leu Lys Asn 
                725                 730                 735     


Lys Arg Ala Arg Arg Glu Ser Tyr Leu Lys Gln Thr Lys Arg Val Leu 
            740                 745                 750         


Ala Asp Asp Glu Leu Leu Ala Asp Thr Leu Leu Gly Lys Ala Thr Thr 
        755                 760                 765             


Ile Ala Glu Leu Glu Glu Ala Phe Thr Ala Glu Ala Leu Ser Ser Gln 
    770                 775                 780                 


Glu Arg Glu Leu Asp Asp Thr Leu Thr Glu Pro Ala Gln Thr Ser Asp 
785                 790                 795                 800 


Lys Pro Val Ser Pro Thr His Pro Pro Ser Asn Pro Tyr Val Pro Asp 
                805                 810                 815     


Arg Ser Gln Gln Ser Gly Glu Thr Gly Ala Leu Gln Gly Phe Arg Cys 
            820                 825                 830         


Glu Val Tyr Ala Tyr Leu Phe Ala Gln Phe Ile Gln Glu Asn His Phe 
        835                 840                 845             


Gly Trp Val Trp Ser Met Ala Glu Pro Ala Gly Ser Glu Ala Thr Lys 
    850                 855                 860                 


Val Ala Val Ala Glu Val Thr Arg Asp Pro Gly Gln Gln Pro Ser Trp 
865                 870                 875                 880 


Leu Arg Gln Phe Tyr Ala Trp Leu Tyr Leu Val Pro Ala Asp Gln Ile 
                885                 890                 895     


Ala Leu Leu Gln His Gln Phe Arg Lys Thr Lys Ile Leu Glu Glu Lys 
            900                 905                 910         


Ala Lys Arg Glu Arg Ala Ile Leu Phe Pro Ala Ala Arg Pro Thr Gly 
        915                 920                 925             


Gly Val Pro Ala Ser Ser Asn Gly Glu Asn Ala Ala Ile Lys Glu Met 
    930                 935                 940                 


Pro Ala Arg Asp Gln Met Phe Ala Ile Met Gln Ala Asn Glu Asp Lys 
945                 950                 955                 960 


Ala Asp Ser Leu Arg Ala Leu Asp Arg Val Met Gly Leu Tyr Thr Arg 
                965                 970                 975     


Val His Ala Ala Gly Phe Ser Gly Glu Glu Phe Ala Ile Ala Lys Gln 
            980                 985                 990         


Phe Phe Ser Asp Gly Asn Val Phe  Asp Glu Leu Phe Ala  Thr Ala Glu 
        995                 1000                 1005             


Ala Glu  Glu Thr Leu Met Leu  Pro Gly Thr Ile Ser  Gly Leu Gln 
    1010                 1015                 1020             


Gln Leu  Ala Arg Leu Gly Thr  Leu Asn Val Leu Lys  Ser Thr Phe 
    1025                 1030                 1035             


Thr Lys  His Gln Val Thr Gln  Gln Glu Ala Arg Ala  Leu Lys Asn 
    1040                 1045                 1050             


Phe Val  Lys Asp Gly Glu Leu  Ala Pro Phe Ile Ala  Lys Gln Asn 
    1055                 1060                 1065             


Leu His  Ala Lys Leu Gln Thr  Ala Trp Lys Glu Lys  Pro Cys Asn 
    1070                 1075                 1080             


Glu Val  Leu Leu Arg Gln Asp  Val Glu Lys Tyr Arg  Glu Ala Ala 
    1085                 1090                 1095             


Ala Glu  Val Ala Gly Tyr Asn  Phe Asp Ile Ala Ala  Ala Arg Leu 
    1100                 1105                 1110             


Ser Asp  Phe Ala Asn Thr His  His Leu Leu Ile Ser  Ile Leu Gly 
    1115                 1120                 1125             


Arg Leu  Ala Asp Phe Thr Ala  Ile Trp Glu Arg Asp  Arg Asp Cys 
    1130                 1135                 1140             


Leu Leu  Leu Ala Leu Ala Phe  Asp His His Pro His  Leu Glu Phe 
    1145                 1150                 1155             


Val Ser  Ser Gly Lys Gly Asp  Val Phe Val Lys Asp  Pro Gly Lys 
    1160                 1165                 1170             


Glu Glu  Ala Phe Gln Val Tyr  Trp Arg Gln Ser Gly  Phe Val Gly 
    1175                 1180                 1185             


Met His  Arg Arg Ser Asp Phe  Leu Val Phe Ala Arg  Cys Ala Glu 
    1190                 1195                 1200             


Gln Pro  Trp Leu Gln Arg Phe  Phe Gly Leu Pro Arg  Asp Asn Glu 
    1205                 1210                 1215             


Arg His  Arg Thr Glu His Thr  Leu Asp Val Ala Arg  Gln Leu Arg 
    1220                 1225                 1230             


Leu Asn  Pro Glu Leu Gln Arg  Gln Gly Lys Thr Glu  Leu Lys Pro 
    1235                 1240                 1245             


Asn Val  Gly His Arg Phe Glu  Val Ser Arg Ile Arg  Asn Asp Leu 
    1250                 1255                 1260             


Ala His  Phe Asn Val Leu Asp  Phe Gln Pro Asp Leu  Arg Lys Pro 
    1265                 1270                 1275             


Gly Lys  His Ser Gly Arg Arg  Ser Leu Asn Leu Thr  Tyr Val Ile 
    1280                 1285                 1290             


Asn Ala  Val Arg Ala Leu Met  Ser Tyr Asp Arg Lys  Phe Lys Asn 
    1295                 1300                 1305             


Ala Val  Pro Lys Ala Ile Ala  Asp Ile Ala Gln Lys  Gln Gly Met 
    1310                 1315                 1320             


Gly Leu  Ser Trp Thr Phe Asn  Arg Asp Arg Leu Leu  Asn Ala Val 
    1325                 1330                 1335             


Leu Thr  Pro Ala Phe His Ser  His Leu Asp Phe Ile  Arg Phe Glu 
    1340                 1345                 1350             


Asp Gly  Ser Arg Pro Thr Phe  Ser Leu Pro Val Val  Ser Pro Arg 
    1355                 1360                 1365             


Arg Leu  Ser Met Thr Arg Ala  Leu Phe Asp Phe Gly  Asn Ser Gly 
    1370                 1375                 1380             


Tyr Leu  Val Asp Thr Ala Thr  Gly Lys Leu Leu Ala  Tyr Pro Glu 
    1385                 1390                 1395             


His Val  Ser Lys Leu Cys Leu  Leu Arg Lys Thr Pro  Thr Arg Leu 
    1400                 1405                 1410             


Phe Gly  Ser Gly Lys Ser Ala  Ser Asp Ser 
    1415                 1420             


<210>  222
<211>  916
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  222

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Ile Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Asp Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Phe 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg 
        915     


<210>  223
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  223

Met Lys Ile Thr Lys Ile Asp Gly Ile Ser His Lys Lys Tyr Ile Lys 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Lys Thr Asp Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Thr Ile Arg Leu Asp Thr Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Glu Phe Phe Ser Asn Lys Val Leu Tyr Leu Lys Asp Gly Ile Leu 
65                  70                  75                  80  


Tyr Leu Lys Asp Arg Arg Glu Lys Asn Gln Leu Gln Asn Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Asn Phe 
            100                 105                 110         


Leu Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Asn Asp Phe Glu Lys Lys Leu Asp Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Leu Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Ile Lys Lys Val Glu Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Phe Tyr Asn Tyr Tyr Lys Asp Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Ile Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Asn Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Thr Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Met 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asn Val Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asn Lys Glu Lys Leu Asn Asp Glu 
        275                 280                 285             


Asn Ile Lys Tyr Val Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Ser Phe Tyr Leu Gln Asp Gly Glu Ile Ala Ile Ser Asp Phe Ile 
        355                 360                 365             


Val Gly Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Thr Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Ile Lys Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Ile Ser Gly Glu Ile Asp Lys Leu Tyr Asp 
            420                 425                 430         


Asn Asn Lys Gln Asn Glu Val Lys Lys Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Val Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Thr Phe Lys Asn Ile Val 
                485                 490                 495     


Pro Ser Gln Ile Ser Lys Lys Met Phe Gln Asp Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Lys Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Asn Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Cys Ile Tyr Trp 
                565                 570                 575     


Lys Ile Pro Lys Ala Asn Asp Asn Asn Lys Thr Lys Glu Ile Thr Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ile Lys Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asn Leu Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Phe Tyr Met Ile Asp Ala Gly Asn Lys Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Ala Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Met 
    690                 695                 700                 


Tyr Ile Gly Asn Asp Glu Gln Ile Asn Thr Ser Leu Ala Gly Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Lys Ile Leu Lys Tyr Thr Glu Ser Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Ala Phe Ser Asp Gln Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Val Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Lys Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Ile Glu Ile Glu Glu Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Asn Asp Glu Lys Phe Asn Asp Glu Asp Tyr Lys 
        915                 920                 925             


Lys Tyr Glu Lys Ala Ile Arg Asn Ile Gln Gln Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Ser Leu Leu Leu 
945                 950                 955                 960 


Arg Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Asn Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Ser Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asp  Thr Glu Lys Ile Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Glu Leu  Lys Lys Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  Asn Ala Glu Val Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Val Lys Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Glu 
    1100                 1105                 1110             


Ile Gln  Ser Leu Lys Ser Glu  Glu Ile Val His Leu  Lys Lys Leu 
    1115                 1120                 1125             


Lys Leu  Lys Asp Asn Asp Lys  Lys Lys Glu Pro Ile  Lys Thr Tyr 
    1130                 1135                 1140             


Arg Asn  Ser Lys Glu Leu Cys  Lys Leu Val Lys Val  Met Phe Glu 
    1145                 1150                 1155             


Tyr Lys  Met Lys Glu Lys Lys  Ser Glu Asn 
    1160                 1165             


<210>  224
<211>  1149
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  224

Met Gly Ala Gly Lys Tyr Arg Ile Thr Lys Ile Pro Arg Asn Trp Lys 
1               5                   10                  15      


Glu Asn Glu Lys Lys Val Ile Leu Lys Arg Val Val Asn Asn Gly Glu 
            20                  25                  30          


Val Lys Tyr Ile Asn Glu Asn Asp Asn Val Asp Val Asp Ile Thr Glu 
        35                  40                  45              


Thr Tyr Tyr Gly Ile Leu Ser Asn Asn Lys Ala Lys Phe Leu Gly Ser 
    50                  55                  60                  


Asn Glu Gln Phe Ile Phe Lys Val Asn Lys Met Lys Arg Asn Ile Glu 
65                  70                  75                  80  


Asn Gly Cys Val Ile Ile Lys Asn Tyr Thr Glu Glu Glu Tyr Glu Lys 
                85                  90                  95      


Phe Asp Lys Lys Ile Phe Ser Lys Arg Arg Ile Lys Val Thr Asn Lys 
            100                 105                 110         


Asn Ile Glu Lys Ile Cys Arg Asn Phe Tyr Glu Asp Glu Glu Glu Ile 
        115                 120                 125             


Met Lys Lys Arg Phe Glu Glu Ala Lys Asn Phe Asn Asn Ile Ile Phe 
    130                 135                 140                 


Lys Ile Cys Ser Glu Ile Phe Glu Leu Glu Tyr Ile Asn Tyr Thr Asp 
145                 150                 155                 160 


Glu Lys Leu Tyr Lys Ile Phe Gln Asn Lys Ile Lys Val Lys Asp Val 
                165                 170                 175     


Lys Asn Leu Lys Glu Ala Phe Lys Gln Gln Glu Lys Gly Leu Glu Thr 
            180                 185                 190         


Asp Lys Leu Leu Ala Ile Ser Phe Asn Lys Lys Arg Asn Asn Ala Leu 
        195                 200                 205             


Leu Glu Phe Ile Gln Gln Ile Val Lys Gln Lys Phe Glu Asn Glu Lys 
    210                 215                 220                 


Glu Leu Glu Asn Trp Phe Ser His Ser Gly Glu Lys Tyr Cys Lys Glu 
225                 230                 235                 240 


Ile Phe Lys Ile Tyr Ser Asn Met Ser Gln Lys Glu Lys Tyr Ser Lys 
                245                 250                 255     


Leu Leu Gly His Arg Asn Lys Ser Phe Ala Ser Ile Ser Glu Lys Lys 
            260                 265                 270         


Glu Thr Leu Gln Arg Arg Leu Lys Leu Gly Asn Tyr Ser Asn Tyr Asn 
        275                 280                 285             


Leu Arg Lys Tyr Tyr Gln Lys Asp Tyr Lys Glu Glu Ala Ile Lys Glu 
    290                 295                 300                 


Leu Lys Asp Lys Ser Lys Glu Lys Leu Glu Lys Glu Ile Glu Glu Ile 
305                 310                 315                 320 


Ile Lys Glu Asn Tyr Lys Ile Asp Lys Leu Cys Glu Glu Ile Ser Asn 
                325                 330                 335     


Leu Glu Phe Ser Phe Ala Glu Ser Lys Lys Glu Asn Lys Asp Lys Met 
            340                 345                 350         


Ser Glu Ile Ile Val Lys Ile Lys Glu His Tyr Lys Asn Asn Val Asn 
        355                 360                 365             


Val Glu Glu Glu Leu Glu Asn Lys Glu Lys Tyr Ile Leu Ser Met Ile 
    370                 375                 380                 


His Asn Tyr Ile Lys Gly Arg Tyr Arg Lys Cys Leu Glu Leu Gln Gln 
385                 390                 395                 400 


Lys Glu Asn Val Asp Phe Glu Asn Leu Glu Lys Arg Ile Lys Glu Ile 
                405                 410                 415     


Phe Asp Ser Asn Glu Val Thr Lys Lys Leu Lys Lys Leu Ile Leu Asn 
            420                 425                 430         


Lys Val Asn Asn Tyr Lys Ile Phe Glu Thr Lys Phe Gln Asn Pro Asn 
        435                 440                 445             


Ile Glu Ser Ser Asp Asp Leu Glu Ile Leu Lys Ala Glu Glu Thr Phe 
    450                 455                 460                 


Leu Asn Lys Leu Ser Thr Ala Val Ser Lys Val Gly Tyr Thr Leu Asn 
465                 470                 475                 480 


Thr Leu Leu Glu Val Ser Pro Glu Lys Asp Ile Leu Glu Lys Tyr Glu 
                485                 490                 495     


Glu Val Glu Lys Leu Cys Thr Ser Asn Ser Ile Lys Asn Leu Cys Thr 
            500                 505                 510         


Val Tyr Ser Glu Ile Asn Asn Asn Glu Lys Leu Leu Lys Gly Met Ile 
        515                 520                 525             


Tyr Phe Ile Gln Gly Leu Arg Gln Gln Val Leu His Pro Lys Ile Leu 
    530                 535                 540                 


Trp Glu Lys Asn Val His Lys Ala Glu Lys Val Lys Glu Lys Glu Lys 
545                 550                 555                 560 


Ile Val Ile Arg Phe Gln Asn Glu Gly Lys Ala Tyr Asn Lys Lys Arg 
                565                 570                 575     


Ile Glu Glu Tyr Phe Glu Asn Ile Leu Glu Lys Ile Pro Asp Tyr Phe 
            580                 585                 590         


Ile Glu Lys Tyr Glu Ser Asn Asn Val Phe Asn Ile Tyr Arg Asn Phe 
        595                 600                 605             


Ile Asp Glu Ile Phe Glu Ile Ile Asp Lys Phe Asp Phe Lys Glu Ser 
    610                 615                 620                 


Asn Ser Ile Ser Tyr Leu Phe Pro Lys Phe His Lys Ile Tyr Lys Arg 
625                 630                 635                 640 


Ile Cys Lys Ser Glu Asn Ile Asn Asp Arg Gln Asn Gly Ala Arg Lys 
                645                 650                 655     


Tyr Leu Leu Gln Thr Ile Tyr Tyr Tyr Tyr Phe Gln Tyr Glu Ile Glu 
            660                 665                 670         


Asn Asn Lys Asn Asp Ile Phe Lys Tyr Leu Asn Leu Tyr Lys Ser Lys 
        675                 680                 685             


Ile Lys Ala Lys Lys Ile Ser Tyr Ser His Ile Ile Asp Asn Lys Asp 
    690                 695                 700                 


Val Asn Asn Lys Asn Ile Glu Ile Leu Tyr Arg Asn Ile Gln Arg Glu 
705                 710                 715                 720 


Gly Met Leu Asn Asn Arg Leu Leu Gln Met Asn Asn Glu Trp Ile Glu 
                725                 730                 735     


Phe Ile Met Ile Gln Phe Ile Glu Phe Ile Ser Thr Lys Lys Leu Asn 
            740                 745                 750         


Trp Ile Leu Asp Asp Leu Ser Glu Tyr Arg Lys Lys Glu Lys Leu Asp 
        755                 760                 765             


Glu Lys Asn Lys Asn Lys Leu Leu Glu Asn Leu Lys Gln Lys Met Asn 
    770                 775                 780                 


Lys Asn Ile Thr Tyr Ser Asn Asp Ser Tyr Val Phe Ile Ser Leu Ala 
785                 790                 795                 800 


Gln Phe Leu Asp Leu Lys Glu Ile Ser Asn Leu Ile His Asp Ile Lys 
                805                 810                 815     


Lys Phe Val Gln Phe Arg Glu Lys Asn Ile Ser Lys Tyr Lys Pro Glu 
            820                 825                 830         


Lys Asn Lys Val Tyr Ile Glu Glu Leu Arg Lys Ile Ser Tyr Ile Leu 
        835                 840                 845             


Lys Val Met Leu Glu His Lys Glu Arg Val Ile Gln Lys His Tyr Leu 
    850                 855                 860                 


Glu Ser Tyr Asp Glu Gly Ile Ser Ile Met Tyr Gly Lys Asp Ile Glu 
865                 870                 875                 880 


Lys Lys Gly Ile Lys Asp Ile Lys Ile Lys Ile Lys Asn Glu Asn Gln 
                885                 890                 895     


Glu Val Ile Asn Gln Pro Leu Tyr Lys Ser Gly Asn Asp Glu Asn Ser 
            900                 905                 910         


Ser Trp Ile Val Leu Tyr Gly Ile Glu Gln Ala Lys Arg Asn Gly Thr 
        915                 920                 925             


Phe Lys Phe Phe Lys Glu Phe Phe Asn Thr Asn Glu Asp Ile Lys Leu 
    930                 935                 940                 


Cys Lys Glu Asp Ile Gln Lys Tyr Glu His Leu Tyr Asn Glu Lys Glu 
945                 950                 955                 960 


Glu Asn Gln Arg Lys Val Asp Glu Tyr Ile Ser Ser Glu Glu Asn Asn 
                965                 970                 975     


Asn Ile Glu Glu Ile Lys Glu Ile Asn Asn Asn Lys Lys Gln Leu Phe 
            980                 985                 990         


Tyr Tyr Tyr Lys Asn Met Ile Asn  Gly Asp Gly Leu Lys  Lys Gly Tyr 
        995                 1000                 1005             


Asp Phe  Ile Asn Asp Ile Tyr  Ser His Cys Leu Ser  Trp Ala Tyr 
    1010                 1015                 1020             


Arg Ile  Glu Arg Asp Cys Ser  Ile Tyr Lys Val Glu  Ala Tyr Asn 
    1025                 1030                 1035             


Gly Lys  Ile Lys Asn Phe Arg  Asn Glu Ile Ala His  Phe Asn Tyr 
    1040                 1045                 1050             


Phe Gln  Lys Thr Asp Lys Ser  Leu Leu Asp Leu Leu  Asn Asp Phe 
    1055                 1060                 1065             


Tyr Asn  Ile Phe Asp Tyr Asn  Leu Lys Tyr Gln Arg  Asp Val Gln 
    1070                 1075                 1080             


Lys Val  Ile Asn Asn Ile Phe  Glu Lys Tyr Gln Val  Val Arg Glu 
    1085                 1090                 1095             


Asp Gly  Gly Pro Val Ile Phe  Tyr Cys Lys Val Asp  Lys Lys Leu 
    1100                 1105                 1110             


Lys Leu  Ser Glu Asn Leu Val  Pro Lys Lys His Ser  Lys Tyr Pro 
    1115                 1120                 1125             


Glu Ile  Glu Leu Val His Lys  Lys Tyr Val Ile Phe  Phe Lys Lys 
    1130                 1135                 1140             


Leu Phe  Glu His Lys Lys 
    1145                 


<210>  225
<211>  1179
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  225

Met Lys Ile Thr Lys Ile Asp Gly Val Ser His Tyr Lys Lys Gln Asp 
1               5                   10                  15      


Lys Gly Ile Leu Lys Lys Lys Trp Lys Asp Leu Asp Glu Arg Lys Gln 
            20                  25                  30          


Arg Glu Lys Ile Glu Glu Arg Tyr Asn Lys Gln Ile Glu Ser Lys Ile 
        35                  40                  45              


Tyr Lys Glu Phe Phe Arg Leu Lys Asp Gly Lys Arg Ile Thr Arg Glu 
    50                  55                  60                  


Glu Lys Asp Gln Asn Ile Lys Ser Leu Tyr Phe Phe Ile Glu Glu Leu 
65                  70                  75                  80  


Tyr Leu Ser Lys Lys Asn Glu Glu Trp Glu Leu Lys Asn Ile Asn Leu 
                85                  90                  95      


Glu Ile Leu Asp Asp Lys Glu Arg Ile Ile Lys Gly Tyr Lys Phe Lys 
            100                 105                 110         


Glu Asp Val Tyr Phe Phe Lys Glu Gly Asp Lys Lys Tyr Tyr Leu Arg 
        115                 120                 125             


Thr Leu Leu Asn Asn Leu Ile Glu Lys Ile Gln Asn Glu Asn Arg Asp 
    130                 135                 140                 


Lys Val Arg Lys Asn Lys Glu Phe Ser Asp Leu Lys Glu Ile Phe Lys 
145                 150                 155                 160 


Lys Tyr Lys Asp Arg Lys Ile Lys Leu Leu Leu Glu Ser Ile Asn Asn 
                165                 170                 175     


Asn Lys Ile Asn Leu Glu Tyr Lys Lys Glu Asn Val Asn Glu Glu Ile 
            180                 185                 190         


Tyr Gly Ile Asn Pro Thr Asn Asp Arg Glu Met Thr Phe Tyr Glu Leu 
        195                 200                 205             


Leu Lys Glu Ile Ile Glu Lys Lys Asp Glu Gln Lys Ser Ile Leu Glu 
    210                 215                 220                 


Glu Lys Leu Asp Asn Phe Asp Ile Thr Asn Phe Leu Glu Asn Ile Glu 
225                 230                 235                 240 


Lys Ile Phe Asn Glu Glu Thr Glu Ile Asn Ile Ile Lys Gly Lys Val 
                245                 250                 255     


Leu Asn Glu Leu Arg Glu Tyr Ile Arg Glu Lys Glu Glu Asn Asn Ser 
            260                 265                 270         


Asp Tyr Lys Leu Lys Gln Ile Tyr Asn Leu Glu Leu Lys Lys Tyr Ile 
        275                 280                 285             


Glu Asn Asn Phe Ser Tyr Lys Lys Gln Lys Ser Lys Ser Lys Asn Gly 
    290                 295                 300                 


Lys Asn Asp Tyr Leu Tyr Leu Asn Phe Leu Lys Lys Ile Met Phe Ile 
305                 310                 315                 320 


Glu Glu Val Asp Glu Lys Lys Gly Ile Asn Lys Glu Lys Phe Lys Asn 
                325                 330                 335     


Lys Ile Asn Ser Asn Phe Lys Asn Leu Phe Val Gln His Ile Leu Val 
            340                 345                 350         


Tyr Gly Lys Leu Leu Tyr Tyr Lys Glu Asn Asp Glu Tyr Ile Lys Asn 
        355                 360                 365             


Thr Gly Gln Leu Glu Thr Lys Asp Leu Glu Tyr Ile Lys Thr Lys Glu 
    370                 375                 380                 


Thr Leu Ile Arg Lys Met Ala Val Leu Val Ser Phe Ala Ala Asn Ser 
385                 390                 395                 400 


Tyr Tyr Asn Leu Phe Gly Arg Val Ser Gly Asp Ile Leu Gly Thr Glu 
                405                 410                 415     


Val Val Lys Ser Ser Lys Thr Asn Val Ile Lys Val Gly Ser His Ile 
            420                 425                 430         


Phe Lys Glu Lys Met Leu Asn Tyr Phe Phe Asp Ser Glu Ile Phe Asp 
        435                 440                 445             


Ala Asn Lys Ile Val Glu Ile Leu Glu Ser Ile Ser Tyr Ser Ile Tyr 
    450                 455                 460                 


Asn Val Arg Asn Gly Val Gly His Phe Asn Lys Leu Ile Leu Gly Lys 
465                 470                 475                 480 


Tyr Lys Lys Lys Asp Ile Asn Ile Asn Lys Arg Val Glu Glu Asp Leu 
                485                 490                 495     


Asn Asn Ser Glu Glu Ile Lys Gly Tyr Phe Ile Lys Lys Arg Gly Glu 
            500                 505                 510         


Ile Glu Lys Lys Ile Lys Glu Arg Phe Leu Ser Asn Asn Leu Glu Tyr 
        515                 520                 525             


Tyr Tyr Ala Lys Glu Arg Ile Glu Asn Tyr Phe Glu Val Tyr Glu Phe 
    530                 535                 540                 


Glu Ile Leu Lys Glu Lys Ile Pro Phe Ala Pro Asn Phe Lys Arg Ile 
545                 550                 555                 560 


Ile Lys Lys Gly Glu Asp Leu Phe Asn Asn Lys Lys Asn Lys Lys Tyr 
                565                 570                 575     


Glu Tyr Phe Lys Asn Phe Asp Lys Asn Ser Ala Glu Glu Lys Lys Glu 
            580                 585                 590         


Phe Leu Lys Thr Arg Asn Phe Leu Leu Lys Glu Leu Tyr Tyr Asn Asn 
        595                 600                 605             


Phe Tyr Lys Glu Phe Leu Ser Lys Lys Glu Glu Phe Lys Lys Ile Val 
    610                 615                 620                 


Ile Glu Val Lys Glu Glu Lys Lys Asn Arg Gly Asn Asn Lys Lys Ser 
625                 630                 635                 640 


Gly Val Ser Phe Gln Ser Ile Asp Asp Tyr Asp Thr Lys Ile Asn Ile 
                645                 650                 655     


Ser Asp Tyr Ile Ala Ser Ile His Lys Lys Glu Met Glu Arg Val Glu 
            660                 665                 670         


Lys Tyr Asn Glu Glu Lys Gln Lys Asp Thr Ala Lys Tyr Ile Arg Asp 
        675                 680                 685             


Phe Val Glu Glu Ile Phe Leu Thr Gly Phe Ile Asn Tyr Leu Glu Lys 
    690                 695                 700                 


Asp Glu Arg Leu His Phe Leu Lys Glu Glu Phe Ser Val Leu Cys Asn 
705                 710                 715                 720 


Ser Asn Asn Asn Ile Ile Asp Phe Asn Val Asn Ile Asn Glu Glu Lys 
                725                 730                 735     


Ile Lys Glu Phe Leu Lys Glu Asn Asp Ser Lys Thr Leu Asn Leu Tyr 
            740                 745                 750         


Leu Phe Phe Asn Met Ile Asp Ser Lys Arg Ile Ser Glu Phe Arg Asn 
        755                 760                 765             


Glu Leu Ile Lys Tyr Lys Gln Phe Thr Lys Lys Arg Leu Asp Glu Glu 
    770                 775                 780                 


Lys Glu Phe Leu Gly Ile Lys Ile Glu Leu Tyr Glu Thr Leu Ile Glu 
785                 790                 795                 800 


Phe Val Ile Leu Thr Arg Glu Lys Leu Asp Thr Lys Lys Ser Glu Glu 
                805                 810                 815     


Thr Asp Ala Trp Leu Val Asp Lys Leu Tyr Val Lys Glu Asn Asn Ala 
            820                 825                 830         


Tyr Lys Glu Tyr Glu Glu Ile Leu Lys Leu Phe Val Asp Glu Lys Ile 
        835                 840                 845             


Leu Ser Ser Lys Glu Ala Pro Tyr Tyr Ala Thr Asp Asn Lys Thr Pro 
    850                 855                 860                 


Ile Leu Leu Ser Asn Phe Glu Lys Thr Arg Lys Tyr Gly Thr Gln Ser 
865                 870                 875                 880 


Phe Leu Ser Glu Ile Gln Ser Asn Tyr Lys Tyr Ser Lys Val Glu Lys 
                885                 890                 895     


Glu Asn Ile Glu Asp Tyr Asn Lys Lys Glu Glu Ile Glu Lys Lys Glu 
            900                 905                 910         


Lys Ser Asn Ile Glu Lys Leu His Asp Leu Lys Val Glu Leu His Lys 
        915                 920                 925             


Lys Trp Glu Lys Asn Lys Ile Thr Glu Lys Glu Ile Lys Lys Tyr Ser 
    930                 935                 940                 


Asp Thr Ile Lys Glu Ile Arg Glu Tyr Asn Tyr Leu Lys Asn Lys Glu 
945                 950                 955                 960 


Glu Leu Gln Asn Val Tyr Leu Leu His Glu Ile Leu Ser Asp Leu Leu 
                965                 970                 975     


Ala Arg Asn Val Ala Phe Phe Asn Lys Trp Glu Arg Asp Phe Lys Phe 
            980                 985                 990         


Ile Val Ile Ala Ile Lys Gln Phe  Leu Arg Glu Asn Asp  Lys Gly Lys 
        995                 1000                 1005             


Val Asn  Glu Phe Leu Asn Pro  Pro Asp Asp Ser Asn  Gly Lys Lys 
    1010                 1015                 1020             


Val Tyr  Phe Ser Val Ser Arg  Tyr Lys Asn Thr Val  Glu Asn Ile 
    1025                 1030                 1035             


Asp Gly  Ile His Lys Asn Phe  Met Asn Leu Ile Phe  Leu Asn Asn 
    1040                 1045                 1050             


Lys Phe  Met Asn Arg Lys Ile  Asn Arg Ile Asn Cys  Thr Ile Trp 
    1055                 1060                 1065             


Val Tyr  Phe Arg Asn Tyr Ile  Ala His Phe Val Tyr  Leu His Thr 
    1070                 1075                 1080             


Lys Asn  Glu Lys Ile Ser Leu  Ile Asn Gln Ile Asn  Leu Leu Ile 
    1085                 1090                 1095             


Lys Leu  Phe Ser Tyr Asp Lys  Lys Val Gln Asn His  Ile Leu Lys 
    1100                 1105                 1110             


Ser Thr  Lys Thr Leu Leu Glu  Lys Tyr Asn Ile Gln  Ile Asn Phe 
    1115                 1120                 1125             


Glu Ile  Ser Asn Asp Lys Asn  Glu Val Phe Lys Tyr  Lys Ile Lys 
    1130                 1135                 1140             


Asp Arg  Leu Tyr Ser Lys Lys  Gly Lys Met Leu Gly  Lys Asn Asn 
    1145                 1150                 1155             


Lys Phe  Glu Ile Leu Glu Lys  Glu Phe Leu Glu Asn  Val Lys Thr 
    1160                 1165                 1170             


Leu Leu  Glu Cys Ser Lys 
    1175                 


<210>  226
<211>  1187
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  226

Met Lys Val Thr Lys Ile Asp Gly Leu Ser His Lys Lys Phe Glu Asn 
1               5                   10                  15      


Glu Gly Lys Leu Ile Lys Ile Lys Asp Ala Ser Gln Lys Asn Glu Thr 
            20                  25                  30          


Lys Glu Arg Leu Glu Lys Leu Lys Glu Ile Lys Leu Gly Asn Tyr Ile 
        35                  40                  45              


Lys Asn Pro Asp Lys Thr Lys Asp Lys Asp Asn Lys Lys Arg Arg Lys 
    50                  55                  60                  


Glu Leu Lys Glu Tyr Phe Ser Glu Ile Thr Leu Arg Lys Glu Asn Gly 
65                  70                  75                  80  


Lys Tyr Val Leu Leu Lys Ser Lys Lys Leu Lys Lys Ile Asn Asn Asn 
                85                  90                  95      


Ile Lys Asp Thr Asp Ile Lys Val Lys His Lys Lys Glu Glu Val Phe 
            100                 105                 110         


Asp Val Leu Lys Glu Ile Leu Gln Leu Asn Leu Leu Ala Asn Asp Val 
        115                 120                 125             


Glu Glu Lys Ile Gln Phe Asp Ser Ile Lys Leu Lys Asn Val Phe Gly 
    130                 135                 140                 


Lys Asp Phe Val Lys Lys Glu Leu Gln Ile Lys Ser Ile Glu Glu Ser 
145                 150                 155                 160 


Leu Glu Lys Asn Lys Ala Asp Tyr Arg Lys Glu Phe Ile Glu Thr Glu 
                165                 170                 175     


Asn Asn Lys Tyr Gly Asn Val Lys Gly Glu Asn Lys Lys Asn Cys Ile 
            180                 185                 190         


Tyr Glu Tyr Tyr Lys Lys Ser Lys Thr His Glu Lys Phe Arg Lys Asn 
        195                 200                 205             


Ile Thr Glu Ala Phe Glu Lys Leu Tyr Thr Glu Glu Asn Ile Lys Glu 
    210                 215                 220                 


Leu Tyr Ser Lys Ile Glu Glu Val Leu Lys Lys Thr His Leu Lys Ser 
225                 230                 235                 240 


Ile Val Arg Glu Phe Tyr Gln Asn Glu Ile Ile Gly Glu Ser Glu Phe 
                245                 250                 255     


Ser Glu Lys Gly Glu Asp Gly Ile Ser Ile Leu Tyr Asn Gln Ile Ile 
            260                 265                 270         


Arg Ser Asn Glu Lys Lys Glu Lys Phe Val Lys Phe Leu Glu Asn Ile 
        275                 280                 285             


Glu Asn Leu Gln Leu Lys Glu Leu Thr Lys Ser Gln Ile Phe Tyr Lys 
    290                 295                 300                 


Tyr Phe Leu Glu Asn Glu Glu Leu Asp Asp Glu Asn Ile Lys Asn Val 
305                 310                 315                 320 


Phe Cys Tyr Phe Val Glu Ile Glu Val Asn Asp Leu Leu Lys Gly Asn 
                325                 330                 335     


Val Tyr Arg Val Ser Lys Ile Tyr Glu Asn Lys Ile Lys Asn Ile Phe 
            340                 345                 350         


Glu Tyr Asn Lys Leu Lys Lys Leu Val Val Asn Lys Leu Lys Asn Lys 
        355                 360                 365             


Leu Asn Asn Tyr Val Arg Asn Cys Gly Lys Tyr Asn Tyr His Met Glu 
    370                 375                 380                 


Asn Gly Asp Ile Ala Thr Ser Asp Ile Asn Met Arg Asn Arg Gln Thr 
385                 390                 395                 400 


Glu Ala Phe Leu Arg Ser Met Ile Gly Val Ser Ser Phe Gly Tyr Phe 
                405                 410                 415     


Ser Leu Arg Asn Ile Leu Gly Val Asn Asp Asp Asp Phe Tyr Glu Ile 
            420                 425                 430         


Glu Glu Asp Leu Thr Glu Asp Glu Arg Lys Asn Glu Ser Asn Val Leu 
        435                 440                 445             


Lys Lys Ala Lys Glu Asp Ile Thr Ser Lys Ser Ile Phe Glu Lys Val 
    450                 455                 460                 


Val Asp Lys Ser Phe Glu Lys Lys Gly Ile His Ser Ile Arg Glu Asn 
465                 470                 475                 480 


Val Lys Met Phe Tyr Gly Val Ser Phe Asp Lys Ala Asn Glu Asp Glu 
                485                 490                 495     


Leu Lys Gln Phe Phe Val Asn Met Leu Asn Ala Ile Thr Ser Ile Arg 
            500                 505                 510         


His Arg Val Val His Tyr Asn Met Asn Thr Asn Ser Glu Asn Ile Phe 
        515                 520                 525             


Asn Phe Ser Asp Ile Glu Val Ser Arg Leu Leu Lys Asn Ile Phe Glu 
    530                 535                 540                 


Lys Glu Thr Asp Lys Arg Glu Leu Lys Leu Lys Ile Phe Arg Gln Leu 
545                 550                 555                 560 


Asn Ser Ala Gly Val Phe Asp Tyr Trp Glu Asp Trp Lys Ile Glu Lys 
                565                 570                 575     


Tyr Leu Lys Asn Ile Glu Phe Lys Phe Val Asn Lys Asn Ile Pro Phe 
            580                 585                 590         


Val Pro Ser Phe Thr Lys Leu Tyr Asn Arg Ile Asp Asn Leu Lys Gly 
        595                 600                 605             


Ser Asn Ala Leu Asn Leu Gly Phe Ile Asn Ile Pro Lys Arg Lys Glu 
    610                 615                 620                 


Ala Arg Asp Ser Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu 
625                 630                 635                 640 


Phe Val Glu Lys Phe Val Asn Asn Asn Asp Asn Phe Glu Lys Ile Phe 
                645                 650                 655     


Arg Glu Ile Ile Glu Ile Asn Lys Asn Ala Gly Thr Asn Thr Lys Thr 
            660                 665                 670         


Lys Phe Tyr Lys Leu Glu Lys Phe Glu Thr Leu Lys Ala Asn Thr Pro 
        675                 680                 685             


Thr Glu Tyr Leu Glu Lys Leu Gln Ser Leu His Gln Ile Asn Tyr Asp 
    690                 695                 700                 


Lys Glu Lys Ile Glu Glu Asp Lys Asp Val Tyr Val Asp Phe Val Gln 
705                 710                 715                 720 


Lys Ile Phe Leu Lys Gly Phe Ile Asn Tyr Leu Gln Lys Ser Asn Ser 
                725                 730                 735     


Leu Lys Leu Leu Asn Leu Leu Asn Leu Lys Lys Asp Glu Val Ile Asn 
            740                 745                 750         


Ser Glu Lys Ser Ser Tyr Asp Glu Lys Leu Lys Gln Trp Glu Asn Asn 
        755                 760                 765             


Gly Ser Lys Leu Ser Glu Met Pro Lys Glu Ile Tyr Arg Tyr Ile Lys 
    770                 775                 780                 


Glu Ile Asn Ile Asn Lys Thr Asn Tyr Ser Asp Arg Met Ser Ile Phe 
785                 790                 795                 800 


Tyr Leu Leu Leu Lys Leu Ile Asp His Lys Glu Leu Thr Asn Leu Arg 
                805                 810                 815     


Gly Asn Leu Glu Lys Tyr Glu Ser Met Asn Lys Asn Lys Ile Tyr Ser 
            820                 825                 830         


Glu Glu Leu Asn Ile Val Asn Leu Val Ser Leu Asp Asn Asn Lys Val 
        835                 840                 845             


Arg Thr Asn Phe Ser Val Glu Ala Glu Asp Ile Gly Lys Phe Leu Lys 
    850                 855                 860                 


Thr Glu Thr Ser Ile Lys Leu Asn Asn Phe Ser Lys Met Phe Ala Asp 
865                 870                 875                 880 


Glu Gln Asn Val Ile Lys His Arg Ser Phe Tyr Asn Ile Lys Lys Tyr 
                885                 890                 895     


Gly Ile Leu Asp Leu Leu Glu Lys Ile Val Ala Lys Ala Asp Leu Lys 
            900                 905                 910         


Ile Thr Lys Glu Glu Ile Lys Lys Tyr Glu Asn Leu Gln Asn Glu Leu 
        915                 920                 925             


Lys Arg Asn Asp Phe Tyr Lys Ile Gln Glu Lys Ile His Arg Lys Tyr 
    930                 935                 940                 


Asn Gln Lys Pro Asn Leu Ile Ser Arg Thr Glu Asn Lys Lys Asp Phe 
945                 950                 955                 960 


Asn Asp Tyr Lys Lys Ala Ile Glu Asn Ile Gln Asn Tyr Thr Gln Leu 
                965                 970                 975     


Lys Asn Lys Ile Glu Phe Asn Asp Leu Asn Leu Leu Gln Ser Leu Leu 
            980                 985                 990         


Phe Arg Ile Leu His Arg Leu Ala  Gly Tyr Thr Ser Leu  Trp Glu Arg 
        995                 1000                 1005             


Asp Leu  Gln Phe Lys Leu Lys  Gly Glu Phe Pro Glu  Asp Lys Tyr 
    1010                 1015                 1020             


Ile Asp  Glu Ile Phe Asn Ser  Asp Gly Asn Asn Asn  Gln Lys Tyr 
    1025                 1030                 1035             


Lys Asn  Gly Gly Ile Ala Asp  Lys Tyr Ala Asp Phe  Leu Ile Glu 
    1040                 1045                 1050             


Lys Glu  Glu Glu Lys Ser Gly  Glu Ile Leu Lys Lys  Asn Gln Arg 
    1055                 1060                 1065             


Asn Lys  Arg Lys Lys Lys Ile  Lys Glu Asp Leu Glu  Ile Arg Asn 
    1070                 1075                 1080             


Tyr Ile  Ala His Phe Asn Tyr  Phe Pro Asp Ala Thr  Lys Ser Ile 
    1085                 1090                 1095             


Leu Glu  Leu Leu Glu Glu Leu  Arg Glu Leu Leu Lys  Tyr Asp Arg 
    1100                 1105                 1110             


Lys Leu  Lys Asn Ala Val Met  Lys Ser Val Lys Asp  Ile Phe Lys 
    1115                 1120                 1125             


Glu Tyr  Gly Phe Ile Val Glu  Phe Gly Ile Ser His  Glu Ser Asn 
    1130                 1135                 1140             


Ser Lys  Lys Ile Lys Val Cys  Asp Val Lys Ser Glu  Glu Ile Lys 
    1145                 1150                 1155             


His Leu  Lys Asn Asn Gly Leu  Val Thr Thr Arg Asn  Ser Glu Asp 
    1160                 1165                 1170             


Leu Cys  Glu Leu Val Lys Val  Met Leu Glu Tyr Lys  Lys Ser 
    1175                 1180                 1185         


<210>  227
<211>  1101
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  227

Met Arg Ile Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Ile Tyr Ser Glu 
            20                  25                  30          


Gln Ala Val Ser Asn Glu Thr Asn Asn Ile Leu Pro Val Lys Lys Met 
        35                  40                  45              


Asp Ser Phe Asn Leu Ser Ile Leu Asn Lys Thr Ile Ile Lys Phe Glu 
    50                  55                  60                  


Thr Val Lys Lys Gln Lys Leu Asn Leu Asp Gln Tyr Lys Ile Val Glu 
65                  70                  75                  80  


Lys Ile Phe Lys Tyr Pro Lys Gln Glu Leu Pro Lys Gln Ile Asn Ala 
                85                  90                  95      


Glu Glu Ile Leu Gln Phe Leu Asn His Lys Phe Gln Glu Pro Val Lys 
            100                 105                 110         


Tyr Trp Lys Asn Gly Lys Glu Glu Ser Phe Asn Leu Thr Leu Leu Ile 
        115                 120                 125             


Val Glu Ala Val Lys Thr Gln Glu Lys Arg Lys Leu Gln Pro Tyr Tyr 
    130                 135                 140                 


Asp Trp Lys Ala Trp Tyr Ile Gln Thr Lys Ser Asp Leu Leu Lys Lys 
145                 150                 155                 160 


Ser Ile Glu Asn Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg 
                165                 170                 175     


Lys Lys Ala Leu Leu Ala Trp Glu Thr Glu Phe Thr Thr Ser Gly Ser 
            180                 185                 190         


Ile Asp Leu Thr His Phe His Lys Val Tyr Met Thr Asp Val Leu Cys 
        195                 200                 205             


Thr Ala Leu Gln Lys Val Glu Pro Ser Ala Asp Glu Arg Gly Lys Met 
    210                 215                 220                 


Asn Ser Asn Ala Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Asn His 
225                 230                 235                 240 


Gln Pro Ala Ile Phe Gly Thr Arg Glu Ala Pro Asn Glu Val Asn Arg 
                245                 250                 255     


Ala Asp Asn Gln Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu 
            260                 265                 270         


Glu His Tyr Phe Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Ala Asp 
        275                 280                 285             


Asp Ile Ser His Tyr Leu Lys Ala Gln Thr Leu Lys Thr Thr Ile Glu 
    290                 295                 300                 


Lys Gln Leu Val Asn Ala Ile Arg Ala Asn Ile Ile Gln Gln Gly Lys 
305                 310                 315                 320 


Thr Asn His His Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile 
                325                 330                 335     


Arg Ile Lys Thr Asn Glu Ala Phe Val Leu Asn Leu Ile Gly Thr Cys 
            340                 345                 350         


Ala Phe Ala Ala Asn Asn Ile Arg Asn Met Val Asp Lys Glu Gln Ile 
        355                 360                 365             


Ser Asp Ile Leu Gly Lys Arg Glu Phe Ile Asp Ser Leu Thr Lys Ser 
    370                 375                 380                 


Arg Ile Ser Ser Gln Leu Tyr Ser Phe Phe Phe Gly Glu Asn Leu Ser 
385                 390                 395                 400 


Thr Asn Lys Ala Glu Lys Glu Thr Gln Leu Trp Gly Ile Arg Gly Ala 
                405                 410                 415     


Val Gln Gln Ile Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu 
            420                 425                 430         


Thr Thr Ile Phe Asn Ile Cys Lys Phe Glu Asn Pro Thr Asp Ala Asp 
        435                 440                 445             


Pro Lys Gln Gln Thr Asn Tyr Val Asp Ser Ile Tyr Lys Thr Leu Phe 
    450                 455                 460                 


Ile Lys Glu Leu Glu Lys Ile Pro Glu Ala Phe Ala Gln Gln Leu Lys 
465                 470                 475                 480 


Thr Gly Gly Ala Leu Ser Tyr Tyr Thr Val Glu Asn Leu Lys Thr Leu 
                485                 490                 495     


Leu Thr Thr Phe Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala 
            500                 505                 510         


Pro Gly Phe Lys Lys Val Leu Asn Gly Gly Ile Asn Tyr Gln Asn Ala 
        515                 520                 525             


Lys Gln Asp Glu Ser Phe Tyr Glu Leu Met Leu Glu Arg Tyr Leu Arg 
    530                 535                 540                 


Lys Glu Asn Phe Ala Glu Glu Ala Tyr Asn Ala Arg Tyr Phe Leu Leu 
545                 550                 555                 560 


Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Lys Phe Thr Ala Asp Arg 
                565                 570                 575     


Lys Ala Phe Ala Asp Ser Val Gly Phe Val Gln Leu Gln Asn Arg Lys 
            580                 585                 590         


Gln Ala Glu Asn Ser Lys Arg Pro Lys Ala Phe Ala Phe Glu Ala Val 
        595                 600                 605             


Arg Pro Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala Tyr Val 
    610                 615                 620                 


Gln Ser Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys Ala Thr 
625                 630                 635                 640 


Asp Glu Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val Phe Ile 
                645                 650                 655     


Lys Gly Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe Val Gln 
            660                 665                 670         


Val Pro Gln Pro Gln Leu Thr Thr Thr Asp Ser Asn Gln Gln Lys Ala 
        675                 680                 685             


Asp Lys Leu Asn Gln Leu Glu Ala Ser Ile Thr Ala Asp Cys Lys Leu 
    690                 695                 700                 


Thr Ala Gln Tyr Ala Lys Thr Asp Asp Ala Thr His Ile Ala Phe Tyr 
705                 710                 715                 720 


Val Phe Cys Lys Leu Leu Asp Ala Gly His Leu Ser Asn Leu Arg Asn 
                725                 730                 735     


Glu Leu Ile Lys Phe Arg Gly Ser Val Lys Asp Phe Asp Phe His His 
            740                 745                 750         


Leu Leu Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val Val Pro 
        755                 760                 765             


Thr Asp Tyr Arg Asp Leu Tyr Ser Ser Gly Ala Asp Cys Leu Ala Arg 
    770                 775                 780                 


Leu Arg Pro Phe Ile Glu Gln Gly Ala Asp Ile Lys Asn Trp Ser Asp 
785                 790                 795                 800 


Leu Tyr Val Gln Thr Asp Lys Gln Thr Pro Val Ile His Ala Gly Ile 
                805                 810                 815     


Glu Leu Ser Val Lys Tyr Gly Thr Thr Ala Leu Leu Glu Gln Leu Ile 
            820                 825                 830         


Thr Cys Asn Pro Lys Phe Arg Val Met Glu Asp Asn Phe Thr Lys Trp 
        835                 840                 845             


Ser Ala Gln Lys Lys Glu Ile Glu Glu Lys Val Asn Lys His Thr Asn 
    850                 855                 860                 


Leu His Gln Gln Trp Val Glu Ala Lys Glu Lys Asp Asp Arg Glu Arg 
865                 870                 875                 880 


Val Lys Ser Lys Lys Asn Phe Val Arg Glu Tyr Val Lys Lys Asn Tyr 
                885                 890                 895     


Val Asp Tyr Ile Asn Asn Cys Ile Glu Ile Asn Asn Tyr Asn Trp Leu 
            900                 905                 910         


Asp Asn Lys Leu His Phe Val His Leu Asn His Leu His His Leu Thr 
        915                 920                 925             


Ile Asp Ile Leu Gly Arg Met Ala Gly Phe Val Ala Leu Trp Glu Arg 
    930                 935                 940                 


Asp Phe Gln Tyr Ile Thr Lys Tyr Thr Ala Ala Lys Glu Gly Thr Asp 
945                 950                 955                 960 


Ala Leu Ser Phe Asp Gly Gly Leu Pro Arg Leu Lys Asp Lys Gln Glu 
                965                 970                 975     


Tyr Tyr Asn Lys Leu Phe Leu Ser Asp Lys Tyr Thr Lys Val Arg Asn 
            980                 985                 990         


His Ile Ala His Phe Asn Tyr Leu  Thr Lys Asp Ala Ala  Asp Phe Ala 
        995                 1000                 1005             


Leu Leu  Asp Leu Ile Asn Glu  Leu Arg Glu Leu Leu  His Tyr Gly 
    1010                 1015                 1020             


Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ala Phe Ile  Asp Leu Phe 
    1025                 1030                 1035             


Glu Lys  His Gly Met Ile Leu  Lys Leu Lys Leu Asn  Thr Asp His 
    1040                 1045                 1050             


Gln Leu  Val Val Glu Ser Ile  Glu Pro Lys Lys Ile  Tyr His Leu 
    1055                 1060                 1065             


Gly Ser  Thr Ala Lys Asp Lys  Pro Glu Tyr Gln Tyr  Thr Thr Asn 
    1070                 1075                 1080             


Gln Val  Met Thr Val Tyr Cys  Asn Met Cys Arg Ser  Leu Leu Glu 
    1085                 1090                 1095             


Met Lys  Lys 
    1100     


<210>  228
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  228

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Asn Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Asn Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Tyr Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Val 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Lys Ile Pro Tyr Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Lys Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Ile 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Val Lys Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Glu 
    1100                 1105                 1110             


Ile Gln  Ser Leu Lys Ser Glu  Glu Ile Val His Leu  Lys Lys Leu 
    1115                 1120                 1125             


Lys Leu  Lys Asp Asn Asp Lys  Lys Lys Glu Pro Ile  Lys Thr Tyr 
    1130                 1135                 1140             


Arg Asn  Ser Lys Glu Leu Cys  Lys Leu Val Lys Val  Met Phe Glu 
    1145                 1150                 1155             


Tyr Lys  Met Glu Glu Lys Ser  Ser Glu Lys 
    1160                 1165             


<210>  229
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  229

Met Gly Ser Gly Lys Tyr Arg Ile Thr Lys Ile Gly Arg Asp Trp Asp 
1               5                   10                  15      


Glu Asn Lys Lys Arg Ile Ile Leu Lys Arg Val Val Ser Asn Gly Lys 
            20                  25                  30          


Val Lys Tyr Ile Asn Glu Asn Asp Asn Val Asp Val Asp Ile Thr Glu 
        35                  40                  45              


Thr Tyr Tyr Gly Ile Leu Ser Asn Asn Lys Ala Lys Phe Leu Gly Ser 
    50                  55                  60                  


Asn Glu Gln Phe Ile Phe Lys Val Asn Lys Met Lys Arg Asn Ile Lys 
65                  70                  75                  80  


Asn Asp Cys Val Ile Ile Lys Asp Tyr Thr Glu Glu Glu Phe Glu Lys 
                85                  90                  95      


Leu Asp Lys Lys Ile Phe Phe Ser Arg Lys Ile Lys Val Asn Asn Glu 
            100                 105                 110         


Asp Arg Glu Lys Ile Cys Arg Asn Phe Tyr Glu Asp Glu Arg Glu Ile 
        115                 120                 125             


Met Lys Lys Arg Phe Glu Glu Ala Lys Lys Phe Asn Asn Ile Ile Phe 
    130                 135                 140                 


Asn Ile Cys Asn Lys Ile Phe Lys Leu Glu Tyr Leu Asp Tyr Ile Asp 
145                 150                 155                 160 


Glu Lys Val Tyr Glu Ile Phe Gln Asn Glu Ile Lys Val Lys Asp Val 
                165                 170                 175     


Lys Asn Leu Lys Glu Ala Phe Lys Gln Gln Glu Lys Gly Leu Glu Thr 
            180                 185                 190         


Asp Lys Leu Leu Ala Ile Ser Phe Asn Lys Lys Arg Asn Asn Val Leu 
        195                 200                 205             


Leu Glu Phe Ile Gln Lys Ile Thr Lys Gln Glu Phe Lys Asn Gln Lys 
    210                 215                 220                 


Glu Leu Glu Asn Trp Phe Ser Gln Ser Gly Glu Lys Tyr Cys Lys Glu 
225                 230                 235                 240 


Ile Phe Lys Ile Tyr Ser Asn Met Ser Gln Lys Glu Lys Tyr Phe Lys 
                245                 250                 255     


Leu Leu Gly His Arg Asn Gln Gly Ile Ala Ser Ile Tyr Asp Glu Lys 
            260                 265                 270         


Lys Glu Thr Leu Gln Arg Arg Leu Lys Leu Gly Asp Tyr Ser Lys Tyr 
        275                 280                 285             


Asp Leu Lys Lys Tyr Tyr Gln Lys Asp Tyr Lys Glu Glu Ala Ile Lys 
    290                 295                 300                 


Glu Leu Lys Asp Lys Asn Lys Glu Glu Leu Glu Arg Glu Ile Glu Lys 
305                 310                 315                 320 


Leu Ile Lys Glu Asn Tyr Lys Ile Asp Glu Leu Cys Tyr Glu Ile Ser 
                325                 330                 335     


Asn Leu Glu Phe Ser Phe Val Asp Ser Lys Lys Glu Asn Lys Asp Lys 
            340                 345                 350         


Met Ser Glu Ile Ile Val Lys Ile Lys Glu His Tyr Lys Asn Asn Val 
        355                 360                 365             


Asn Ile Glu Glu Arg Leu Glu Asn Lys Glu Lys Tyr Ile Leu Ser Met 
    370                 375                 380                 


Ile His Asn Tyr Val Lys Gly Arg Tyr Arg Lys Cys Leu Glu Leu Gln 
385                 390                 395                 400 


Gln Lys Glu Asn Val Asp Leu Glu Asn Leu Gly Lys Arg Ile Lys Glu 
                405                 410                 415     


Ile Phe Asp Ser Asn Gln Val Thr Lys Lys Leu Lys Lys Ser Ile Leu 
            420                 425                 430         


Asn Lys Val Asn Asn Tyr Lys Ile Phe Glu Thr Lys Phe Gln Asn Pro 
        435                 440                 445             


Asn Ile Glu Ser Ser Asp Asp Leu Glu Ile Leu Lys Ala Glu Glu Thr 
    450                 455                 460                 


Phe Leu Asn Lys Leu Ser Thr Ala Val Ser Lys Val Gly Tyr Thr Leu 
465                 470                 475                 480 


Asn Thr Leu Leu Glu Val Ser Pro Glu Lys Asp Ile Leu Glu Asn Tyr 
                485                 490                 495     


Asn Met Val Val Glu Leu Cys Asn Asn Asn Ser Thr Thr Glu Ile Tyr 
            500                 505                 510         


Lys Val Tyr Pro Glu Leu Glu Lys Asn Glu Lys Leu Leu Gln Gly Met 
        515                 520                 525             


Ile His Phe Ile Gln Gly Ile Arg Gln Gln Ser Leu His Pro Lys Ile 
    530                 535                 540                 


Ser Trp Asn Phe Glu Thr Lys Asn Leu Lys Pro Glu Lys Leu Glu Arg 
545                 550                 555                 560 


Leu Lys Glu Lys Lys Asn Ile Lys Met Arg Asp Cys Val Val His Glu 
                565                 570                 575     


Asp Asn Leu Asp Lys Lys Glu Lys Ser Glu Val Glu Ile Lys Arg Tyr 
            580                 585                 590         


Phe Glu Lys Ile Glu Glu Lys Leu Pro Asp Tyr Phe Ile Glu Lys Tyr 
        595                 600                 605             


Glu Ser Asn Asn Val Phe Asn Ile Tyr Arg Asn Phe Val Asp Lys Ile 
    610                 615                 620                 


Met Glu Ala Val Lys Asn Phe Asn Phe Lys Glu Asn Asn Thr Ile Asp 
625                 630                 635                 640 


Tyr Leu Phe Pro Lys Phe His Lys Ile Tyr Lys Arg Met Tyr Lys Ser 
                645                 650                 655     


Glu Asn Ile Asp Asp Arg Gln Asn Gly Ala Arg Lys Tyr Leu Leu Gln 
            660                 665                 670         


Thr Ile Tyr Tyr Tyr Tyr Phe Gln Tyr Lys Ile Glu Asn Asp Lys Asn 
        675                 680                 685             


Asp Ile Phe Lys Tyr Leu Asn Leu Tyr Lys Asn Lys Ile Lys Ala Lys 
    690                 695                 700                 


Lys Ile Ser Tyr Ser Tyr Ile Ile Asp Asn Lys Asn Val Asn Asn Lys 
705                 710                 715                 720 


Asn Ile Glu Ile Leu Tyr Arg Asn Ile Gln Arg Glu Gly Met Leu Asn 
                725                 730                 735     


Asn Arg Leu Ser Gln Met Asn Asn Glu Trp Ile Glu Phe Ile Val Val 
            740                 745                 750         


Gln Phe Ser Glu Phe Leu Thr Asn Lys Lys Leu Asn Trp Ile Leu Asp 
        755                 760                 765             


Asp Leu Ser Glu Tyr Lys Lys Lys Glu Lys Leu Asp Glu Asn Asn Lys 
    770                 775                 780                 


Asn Lys Leu Leu Lys Ile Leu Lys Gln Lys Met Asn Lys Lys Ile Ile 
785                 790                 795                 800 


Tyr Ser Asn Asp Ser Tyr Val Phe Ile Ser Leu Ala Gln Phe Leu Asp 
                805                 810                 815     


Leu Lys Glu Ile Ser Asn Leu Ile His Asp Ile Lys Lys Phe Val Gln 
            820                 825                 830         


Phe Arg Glu Lys Asn Ala Ser Lys Tyr Lys Pro Glu Lys Asn Glu Leu 
        835                 840                 845             


Tyr Ile Glu Glu Leu Lys Lys Val Leu Tyr Ile Leu Lys Val Met Leu 
    850                 855                 860                 


Glu His Lys Glu Arg Val Ile Gln Lys His Tyr Leu Glu Ser Tyr Asp 
865                 870                 875                 880 


Glu Asp Ile Ser Ile Ile Tyr Gly Lys Glu Ile Glu Lys Lys Asp Ile 
                885                 890                 895     


Lys Asp Ile Glu Ile Glu Ile Lys Ile Lys Asn Glu Asn Gln Glu Val 
            900                 905                 910         


Asn Gln Glu Val Ile Val Ile Asn Gln Pro Leu Tyr Lys Ser Gly Asp 
        915                 920                 925             


Asp Glu Asn Ser Ser Trp Ile Ile Leu Tyr Gly Ile Glu Gln Ala Lys 
    930                 935                 940                 


Arg Asn Gly Thr Phe Lys Phe Phe Glu Gly Phe Phe Asn Leu Asn Asp 
945                 950                 955                 960 


Asp Ile Lys Leu Cys Lys Glu Asn Ile Lys Lys Tyr Glu Glu Leu Tyr 
                965                 970                 975     


Asn Lys Arg Lys Glu Asn Gln Ile Lys Val Asp Glu Tyr Ile Ser Ser 
            980                 985                 990         


Glu Glu Asn Asn Asn Ile Asp Glu  Ile Lys Glu Ile Asn  Asn Asn Lys 
        995                 1000                 1005             


Gln Leu  Phe Tyr Tyr Tyr Lys  Asn Met Ile Tyr Gly  Asp Gly Leu 
    1010                 1015                 1020             


Lys Lys  Gly Tyr Asp Phe Ile  Asn Asp Ile Tyr Ser  His Tyr Leu 
    1025                 1030                 1035             


Ser Trp  Ala Tyr Arg Ile Glu  Arg Asp Tyr Ser Ile  Tyr Lys Val 
    1040                 1045                 1050             


Lys Ile  Tyr Asn Gly Lys Ile  Lys Asn Phe Arg Asn  Glu Ile Ala 
    1055                 1060                 1065             


His Phe  Asn Tyr Phe Gln Lys  Thr Asn Lys Ser Leu  Leu Glu Leu 
    1070                 1075                 1080             


Leu Asn  Asp Phe Tyr Asp Ile  Phe Asp Tyr Asn Leu  Lys Tyr Gln 
    1085                 1090                 1095             


Arg Asp  Val Gln Asn Val Ile  Asn Asn Ile Phe Glu  Lys Tyr Gln 
    1100                 1105                 1110             


Ile Val  Arg Lys Asp Gly Gly  Pro Val Val Phe Tyr  Cys Lys Thr 
    1115                 1120                 1125             


Asp Lys  Lys Leu Lys Leu Ser  Glu Asn Leu Val Pro  Lys Lys His 
    1130                 1135                 1140             


Ser Lys  Tyr Pro Glu Ile Lys  Leu Ile His Glu Lys  Tyr Val Met 
    1145                 1150                 1155             


Phe Phe  Arg Lys Leu Phe Glu  Tyr Lys Lys 
    1160                 1165             


<210>  230
<211>  1165
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  230

Met Lys Ile Ser Lys Val Asn His Val Arg Thr Gly Thr Thr Val Thr 
1               5                   10                  15      


Gln Met Gln Gly Glu Gly Ile Ile Tyr Val Asn Pro Ser Gln Asn Lys 
            20                  25                  30          


Asn Ala Lys Lys Asp Leu Thr Glu His Ile Lys Lys Leu Asn Glu Lys 
        35                  40                  45              


Ala Lys Val Leu Tyr Ser Pro Ile Asn Pro Val Asn Ser Ile Thr Val 
    50                  55                  60                  


Ser Met Asp Lys Asn Glu Lys Gln Asp Val Asn Ala Ser Ala Lys Ala 
65                  70                  75                  80  


Ile Lys Tyr Leu Val Asn Gly Ile Leu Arg Lys Asn Glu Asn Gly Ile 
                85                  90                  95      


Pro Asp Cys Asp Ser Leu Leu Ser Gln Ile Arg Glu Lys Ala Arg Glu 
            100                 105                 110         


Ala His Thr Ser Ser Ile Asn Pro Asp Lys Leu Ala Glu Lys Ile Val 
        115                 120                 125             


Asp Arg Cys Leu Arg Lys Lys Leu Cys Lys Lys Ser Glu Ile Ala Lys 
    130                 135                 140                 


Ala Leu Phe Ala Ala Ile Leu Ser Ser Asn Lys Ala Glu Arg Leu Asn 
145                 150                 155                 160 


Leu Leu Asp Lys Asp Glu Val Lys Ala Phe Phe Asp Leu Ala His Glu 
                165                 170                 175     


Asp Tyr Tyr Lys Thr Glu Gln Leu Lys Glu Ile Glu Asp Ser Ile Val 
            180                 185                 190         


Lys Lys Asp Val Arg Val Gln Val Lys Glu Gly Met Asp Gly Glu Lys 
        195                 200                 205             


His Leu Val Leu Ser Ser Ala Asp Asn Pro Lys Lys His Phe Tyr Phe 
    210                 215                 220                 


Asp Phe Ile Lys Glu Tyr Thr Ser Lys Asp Asn Ala Gly Arg Glu Glu 
225                 230                 235                 240 


Met Leu Ile Arg Phe Arg Gln Leu Ile Ile Leu Phe Tyr Ser Gly Val 
                245                 250                 255     


Lys Ala Tyr His Leu Ser Ile Gly Ser Asp Val Gly Ala Trp Thr Phe 
            260                 265                 270         


Gly Ser Ser Leu Pro Asp Val Ala Asp Asn Phe Asn Asp Glu Ala Ala 
        275                 280                 285             


Ala Leu Ile Thr Glu Cys Gln Ile Gln Gln Ala Glu Lys Glu Lys Tyr 
    290                 295                 300                 


Gly Lys Lys Lys Asn Ile Leu Ser Asp Lys Leu Lys Asn Cys Lys Tyr 
305                 310                 315                 320 


Gly Thr Pro Glu Tyr Arg Asn Leu Leu Gly Gln Glu Thr Asp Cys Lys 
                325                 330                 335     


Thr Ala Ile Ala Ser Cys Asn Ser Ala Ile Gly Asn Ala Gln Lys Lys 
            340                 345                 350         


Ile Lys Val Leu Leu Ala Asp Thr Ile Cys Asn Asn Tyr Arg Thr Ala 
        355                 360                 365             


Val Lys Thr Glu Gly Leu Ala Glu Gly Asp Ile Phe Trp Ile Gly Tyr 
    370                 375                 380                 


Ile Gln Gly Ile Ala Glu Lys Leu Phe Glu Lys Lys Ser Ser Tyr Thr 
385                 390                 395                 400 


Met Tyr Lys Met Ser Thr Lys Tyr Leu Tyr Glu Val Thr Phe Asn Glu 
                405                 410                 415     


Trp Leu Ser Phe Val Ala Leu Lys Val Ile Asp Met Gly Lys Ala Val 
            420                 425                 430         


Tyr His Phe Ala Met Pro Asp Cys Ser Asp Ile Cys Ser Gly Ala Glu 
        435                 440                 445             


Ile Arg Ala Gly Lys Val Gln Pro Leu Phe Glu Asp Gly Ile Thr Ser 
    450                 455                 460                 


Phe Asp Tyr Glu Arg Ile Lys Ala Lys Glu Thr Ile Thr Arg Glu Phe 
465                 470                 475                 480 


Ala Val His Ala Thr Tyr Ala Ala Gly Ile Phe Ser Asn Ala Val Ala 
                485                 490                 495     


Asp Lys Glu Tyr Arg Leu His Thr Glu Thr Asp Glu Lys Gly Arg Thr 
            500                 505                 510         


Leu Asn Phe Glu Asp Pro Leu Gln Tyr Lys Glu Lys Glu Trp Val Gln 
        515                 520                 525             


Ala Leu Val Pro Asp Ala Lys Lys Lys Leu Leu Met Phe Phe Gly Gly 
    530                 535                 540                 


Gln Ser Gly Trp Asp Gly Thr Glu Ile Ala Ala Lys Ser Asp Leu Glu 
545                 550                 555                 560 


Val Thr Ser Ala Phe Gln Glu Met Ile Asn Val Ile Arg Asn Ser Asn 
                565                 570                 575     


Tyr His Tyr Ala Gly Ser Ile Val Ser Pro Lys Glu Glu Thr Ile Thr 
            580                 585                 590         


Ile Met Arg Gly Leu Phe Asp Lys Glu Phe Ser Glu Leu Gly Arg Ile 
        595                 600                 605             


Leu Arg Glu Lys Tyr Tyr Ser Asn Asn Val Pro Val Tyr Tyr Gly Ile 
    610                 615                 620                 


Gly Asp Ile Asp Lys Leu Met Thr Phe Leu Tyr Thr Gly Glu Ser Lys 
625                 630                 635                 640 


Arg Glu Ala Gln Ile Pro Ser Phe Gly Asn Ile Phe Lys Lys Lys Asp 
                645                 650                 655     


Ile Pro Asp Phe Val Lys Lys Asn Ile Ala Gly Ser Leu Leu Ala Lys 
            660                 665                 670         


Tyr Asn Val Gln Glu Leu Glu Lys Phe Arg Ser Ala Leu Tyr Phe Val 
        675                 680                 685             


Leu Lys Glu Ile Tyr Tyr Tyr Gly Phe Leu Lys Glu Thr Asn Ile Lys 
    690                 695                 700                 


Asp Arg Phe Leu Ala Phe Leu Asn Lys Ser Lys Asn Ser Ala Lys Asn 
705                 710                 715                 720 


Pro Asp Ala Tyr Asn Ser Phe Gln Ser Arg Leu Lys Asp Leu Asp Ala 
                725                 730                 735     


Asp Cys Ser Phe Gly Glu Ile Cys Gln Met Tyr Met Thr Asp Tyr Asn 
            740                 745                 750         


Gln Gln Asn Gln Gly Asn Tyr Lys Val Lys Ser Gln Thr Gln Glu Glu 
        755                 760                 765             


Lys Asp Arg Lys Asp Asp Lys Gly His Lys Tyr Glu His Phe Lys Met 
    770                 775                 780                 


Leu Leu Tyr Val Thr Ile Gln Gly Ala Phe Thr Asp Tyr Leu Ala Glu 
785                 790                 795                 800 


Lys Lys Glu Ile Phe Ser Phe Leu Met Ala Pro Asp Leu Lys Glu Asn 
                805                 810                 815     


Phe Phe Gly Ser Asn Ala Ala Lys Gly Phe Ile Ser Ser Trp Lys Ala 
            820                 825                 830         


Asp Leu Phe Asn Glu Thr Lys Lys Val Leu Ser Glu Asp Ala Tyr Val 
        835                 840                 845             


Leu Ser Trp Tyr Ala Leu Ala His Leu Leu Ser Pro Lys Gln Leu Asn 
    850                 855                 860                 


His Leu Gln Gly Asp Ile Lys Ser Tyr Ile Gln Phe Val Gly Glu Ile 
865                 870                 875                 880 


Asn Ala Arg Glu Lys Ser Val Leu Gly Arg Glu Arg Asp Thr Arg Leu 
                885                 890                 895     


Thr Asp Thr Thr Gly Asp Phe Glu Lys Ile Leu Lys Val Leu Glu Phe 
            900                 905                 910         


Val Met Asn Phe Val Gly Lys Thr Ser Asn Val Leu Thr Asp Tyr Phe 
        915                 920                 925             


Ala Asp Ala Asp Asp Tyr Ala Lys His Leu Tyr Ser Tyr Val Ser Tyr 
    930                 935                 940                 


Ala Gly Lys Lys Glu Glu Lys Asn Asn Ala Ala Leu Ala Ala Phe Cys 
945                 950                 955                 960 


Gln Lys Ala Ile Thr Gln Lys Asp Ile Thr Leu Thr Asp Lys Ile Gly 
                965                 970                 975     


Ile Tyr His Asp Gly Ile Asn Pro Ile Val Asn Thr Asn Val Val Lys 
            980                 985                 990         


Ala Met Met Tyr Gly Asn Glu Thr  Ile Leu Ser Glu Ala  Val Ser Lys 
        995                 1000                 1005             


Val Ser  Gly Asp Leu Phe His  Gly Asp Ile Val Ser  Tyr Phe Arg 
    1010                 1015                 1020             


Leu Lys  Lys Glu Leu Glu Lys  Val Phe Glu Lys Gly  Glu Cys Ala 
    1025                 1030                 1035             


Asn Arg  Glu Glu Gln Thr Lys  Leu Arg Glu Phe Gln  Asn Leu Lys 
    1040                 1045                 1050             


Asn Arg  Val Glu Leu Tyr Asp  Ile Ala Val Phe Thr  Asp Ile Ile 
    1055                 1060                 1065             


Asn Asp  Tyr Met Gly Glu Leu  Val Asn Met Ala Tyr  Leu Arg Glu 
    1070                 1075                 1080             


Arg Asp  Leu Met Tyr Tyr Gln  Leu Gly Tyr His Tyr  Leu Arg Gln 
    1085                 1090                 1095             


Glu Tyr  Ala Thr Val Glu Glu  Lys Tyr Lys Thr Ile  Ser Glu Glu 
    1100                 1105                 1110             


Asn Ile  Cys Ile Thr Ser Gly  Ala Leu Leu Tyr Gln  Ile Met Ala 
    1115                 1120                 1125             


Met Tyr  Ser Tyr Asn Leu Pro  Ile Ile Tyr Lys Gly  Lys Glu Gly 
    1130                 1135                 1140             


Thr Tyr  Lys Tyr Ser Asn Gly  Gly Lys Ile Asn Lys  Phe Val Lys 
    1145                 1150                 1155             


Asn Tyr  Cys Gly Glu Asn Leu  
    1160                 1165 


<210>  231
<211>  1380
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  231

Met Lys Leu Ser Lys Glu Lys Gln Ile Arg Ser Ala Val Ala Asn Lys 
1               5                   10                  15      


Glu Lys Asn Thr Glu Gly Val Leu Tyr Arg Phe Pro Gly Asp Asp Ile 
            20                  25                  30          


Gly Gly Val Gln Ala Gln Met Leu Val Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Leu Gly Asn Lys Pro Lys Glu 
    50                  55                  60                  


Trp Met Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Lys Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Ala Ile Asn Asp Ile Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Lys Glu Ala Asp Lys Lys Ile Arg Asn Met Ser Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Asn Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Ser Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Gly Asn Gln Glu Phe Asp Ser Ile Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Asp Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Ser Ile Gln Asp Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Ile Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Glu Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Asp Gly Leu Asn Glu Phe Met Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Glu Glu Lys Arg Ala Glu Val Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Ile His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Val Asn Lys Gly Lys Phe Tyr Val Trp 
305                 310                 315                 320 


Lys Lys His Glu Cys Gly Lys Lys Glu Asn Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Val Glu Ala Glu Ala Glu Ser Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Ile Phe Phe Glu Asn Asp Thr Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Thr Gly Thr Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Lys Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asn Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Gln Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Leu 
            660                 665                 670         


Val Arg Thr Val Phe Pro Glu Tyr Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Asn Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Arg Thr Leu Arg Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Lys 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Glu Asn Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Cys Ala Gln Asp 
            900                 905                 910         


Ile Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu 
        915                 920                 925             


Leu Ser Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Lys Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Lys Phe Ser Glu Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Thr Asn Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Gly  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Glu Lys Pro Glu  Glu Tyr Glu Lys Ile  Glu Ala Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Ile  Tyr Ala Pro Glu Lys  Asn Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Gln Gly Arg Val Gly  Ala Lys Val 
    1145                 1150                 1155             


Thr Ser  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Glu Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Met Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Val Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Val Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Glu Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asn Ala 
    1280                 1285                 1290             


Lys Asp  Lys Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Asp  Ala Glu Asp Ala Asp  Ser Lys Lys Pro Val  Ile Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Glu  Asp Glu Asp 
    1325                 1330                 1335             


Lys Gln  Lys Gly Lys Glu Asn  Arg Gly Lys Lys Asn  Thr Glu Thr 
    1340                 1345                 1350             


Arg Ser  Asp Ala Glu Lys Asn  Asn Asn Glu Arg Leu  Ser Tyr Asn 
    1355                 1360                 1365             


Pro Phe  Ala Asn Phe Asp Phe  Lys Leu Pro Asn Lys  
    1370                 1375                 1380 


<210>  232
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  232

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Gly Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asp 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  233
<211>  1380
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  233

Met Lys Leu Ser Lys Glu Lys Gln Ile Arg Ser Ala Val Ala Asn Lys 
1               5                   10                  15      


Glu Lys Asn Thr Glu Gly Val Leu Tyr Arg Phe Pro Gly Asp Asp Ile 
            20                  25                  30          


Gly Gly Val Gln Ala Gln Met Leu Val Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Leu Gly Asn Lys Pro Lys Glu 
    50                  55                  60                  


Trp Met Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Lys Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Ala Ile Asn Asp Ile Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Lys Glu Ala Asp Lys Lys Ile Arg Asn Met Ser Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Asn Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Ser Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Gly Asn Gln Glu Phe Asp Ser Ile Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Asp Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Ser Ile Gln Asp Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Ile Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Glu Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Asp Gly Leu Asn Glu Phe Met Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Glu Glu Lys Arg Ala Glu Val Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Ser His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Val Asn Lys Gly Lys Phe Tyr Val Trp 
305                 310                 315                 320 


Lys Lys His Glu Cys Gly Lys Lys Glu Asn Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Val Glu Ala Glu Ala Glu Ser Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Ile Phe Phe Glu Asn Asp Thr Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Thr Gly Thr Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Lys Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asn Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Gln Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Leu 
            660                 665                 670         


Val Arg Thr Val Phe Pro Glu Tyr Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Asn Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Arg Thr Leu Arg Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Lys 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Glu Asn Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Cys Ala Gln Asp 
            900                 905                 910         


Ile Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu 
        915                 920                 925             


Leu Ser Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Lys Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Lys Phe Ser Glu Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Thr Asn Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Gly  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Glu Lys Pro Glu  Glu Tyr Glu Lys Ile  Glu Ala Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Ile  Tyr Ala Pro Glu Lys  Asn Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Gln Gly Arg Val Gly  Ala Lys Val 
    1145                 1150                 1155             


Thr Ser  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Glu Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Met Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Val Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Val Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Glu Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asn Ala 
    1280                 1285                 1290             


Lys Asp  Lys Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Asp  Ala Glu Asp Ala Asp  Ser Lys Lys Pro Val  Ile Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Glu  Asp Glu Asp 
    1325                 1330                 1335             


Lys Gln  Lys Gly Lys Glu Asn  Arg Gly Lys Lys Asn  Thr Glu Thr 
    1340                 1345                 1350             


Arg Ser  Asp Ala Glu Lys Asn  Asn Asn Glu Arg Leu  Ser Tyr Asn 
    1355                 1360                 1365             


Pro Phe  Ala Asn Phe Asp Phe  Lys Leu Pro Asn Lys  
    1370                 1375                 1380 


<210>  234
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  234

Met Gly Asn Leu Phe Gly His Lys Lys Trp Tyr Lys Ala Asp Lys Ile 
1               5                   10                  15      


Ile Lys Asp Lys Lys Gly Lys Glu Ser Thr Ile Lys Gln Glu Val Arg 
            20                  25                  30          


Ile Lys Arg Asn Tyr Ser Val Asp Arg Tyr Thr Leu Asn Thr Asn Asn 
        35                  40                  45              


Lys Glu Lys Asn Asn Ile Asn Asn Glu Asp Phe Val Asn Gln Phe Ile 
    50                  55                  60                  


Glu Tyr Lys Thr Asn Asn Asp Ile Phe Lys Lys Phe Thr Arg Lys Phe 
65                  70                  75                  80  


His Met Gly Asn Ile Leu Phe Lys Leu Lys Gly Asn Lys Arg Ser Ile 
                85                  90                  95      


Glu Asp Ser Asn Asp Phe Leu Lys Thr Glu Glu Ile Ile Leu Asp Lys 
            100                 105                 110         


Glu Val Tyr Gly Gln Ser Glu Lys Leu Arg Asn Glu Lys Gly Ile Thr 
        115                 120                 125             


Lys Gln Gly Ile Leu Lys Glu Ile Asn Tyr Arg Gly Ile Asn Glu Ser 
    130                 135                 140                 


Asn Asp Ser Ile Leu Ile Lys Thr Lys Phe Gly Lys Glu Ile Lys Ile 
145                 150                 155                 160 


Asn Phe Thr Asp Glu Ala Lys Lys Asn Lys Asn Glu Tyr Gln Ile Thr 
                165                 170                 175     


Leu Lys Ile Ile Pro Glu Asn Glu Leu Lys Ile Lys Arg Glu Val Tyr 
            180                 185                 190         


Asp Val Phe Lys Met Ile Asn Met Asp Leu Tyr Gln Ile Ile Lys Glu 
        195                 200                 205             


Ile Ile Glu Asn Glu Val Gln Lys Val Phe Lys Asn Arg Tyr Tyr Glu 
    210                 215                 220                 


Glu Tyr Leu Arg Glu Lys Leu Leu Lys Asp Asp Lys Thr Gly Val Ile 
225                 230                 235                 240 


Leu Thr Asn Phe Ile Glu Ile Arg Glu Lys Ile Lys Ser Asn Leu Glu 
                245                 250                 255     


Ile Met Gly Phe Val Lys Phe Tyr Leu Asn Val Gly Gly Asp Lys Lys 
            260                 265                 270         


Lys Ser Glu Asn Lys Lys Ile Phe Val Glu Lys Ile Leu Asn Ile Asn 
        275                 280                 285             


Val Asp Leu Thr Val Glu Asp Ile Val Asp Phe Ile Val Lys Glu Leu 
    290                 295                 300                 


Lys Phe Trp Asn Ile Thr Lys Arg Ile Glu Lys Leu Gln Glu Lys Thr 
305                 310                 315                 320 


Val Asn Arg Ala Asp Glu Asp Ile Glu Asn Thr Tyr Ile Asn Thr Tyr 
                325                 330                 335     


Val Leu Leu Asp Lys His Glu Lys Phe Lys Lys Tyr Asn Arg Asn Lys 
            340                 345                 350         


Lys Asp Thr Ile Val Lys Ser Phe Ile Lys Asp Ile Lys Asp Asn Thr 
        355                 360                 365             


Met Lys Gln Lys Ile Asn Gln Ile Leu Arg Lys Phe Lys Ile Asp Glu 
    370                 375                 380                 


Leu Ile Lys Lys Thr Glu Lys Glu Leu Lys Arg Gly Asn Cys Asp Thr 
385                 390                 395                 400 


Glu Ile Phe Gly Ile Phe Lys Val His Tyr Gln Glu Met Phe Ser Ser 
                405                 410                 415     


Glu Lys Phe Glu Lys Lys Ser Asp Glu Glu Lys Glu Leu Tyr Lys Ile 
            420                 425                 430         


Ile Tyr Arg Tyr Leu Lys Gly Arg Ile Glu Lys Ile Leu Val Asn Glu 
        435                 440                 445             


Gln Lys Val Arg Leu Lys Lys Ile Glu Lys Ile Leu Asn Glu Ser Ile 
    450                 455                 460                 


Leu Ser Glu Lys Ile Leu Lys Arg Val Lys Gln Tyr Thr Leu Glu Tyr 
465                 470                 475                 480 


Ile Met Tyr Leu Gly Lys Leu Val His Asn Lys Ile Asn Met Ala Thr 
                485                 490                 495     


Val Asn Thr Asn Asp Phe Phe Arg Leu His Ala Lys Glu Glu Leu Asp 
            500                 505                 510         


Leu Glu Leu Ile Thr Phe Phe Ala Ser Thr Asn Met Glu Leu Asn Lys 
        515                 520                 525             


Ile Phe Asn Gly Lys Glu Lys Val Thr Asp Phe Phe Gly Phe Asn Leu 
    530                 535                 540                 


Asn Gly Gln Lys Ile Thr Leu Lys Glu Lys Val Pro Ser Phe Lys Leu 
545                 550                 555                 560 


Asn Ile Leu Lys Lys Leu Asn Phe Ile Asn Asn Glu Asn Asn Ile Asp 
                565                 570                 575     


Glu Lys Leu Ser His Phe Tyr Ser Phe Gln Lys Lys Gly Tyr Leu Leu 
            580                 585                 590         


Arg Asn Lys Ile Leu His Asn Ser Tyr Gly Asn Ile Gln Glu Thr Ile 
        595                 600                 605             


Asn Leu Lys Gly Glu Tyr Glu Asn Val Glu Asn Leu Ile Lys Glu Leu 
    610                 615                 620                 


Lys Val Ser Asn Glu Glu Ile Ser Lys Ser Leu Asn Leu Asp Ile Ile 
625                 630                 635                 640 


Phe Glu Gly Lys Val Asp Ile Ile Asn Lys Ile Asn Ser Leu Glu Ile 
                645                 650                 655     


Gly Glu Tyr Lys Asp Lys Lys Tyr Leu Pro Ser Phe Ser Lys Ile Val 
            660                 665                 670         


Pro Glu Ile Met Arg Lys Phe Arg Glu Ile Asn Lys Asp Lys Ser Phe 
        675                 680                 685             


Asp Ile Glu Ser Glu Lys Ile Ile Leu Asn Ala Val Gln Tyr Val Asn 
    690                 695                 700                 


Lys Ile Leu Tyr Glu Lys Ile Thr Ser Asn Glu Glu Asn Glu Phe Ile 
705                 710                 715                 720 


Lys Thr Leu Pro Asp Lys Leu Val Lys Lys Asn Asn Asn Lys Glu Asn 
                725                 730                 735     


Asn Asn Ser Leu Ser Ile Glu Glu Tyr Tyr Lys Asn Ala Gln Ile Ser 
            740                 745                 750         


Ser Ser Lys Gly Asp Lys Lys Ala Ile Lys Lys Tyr Gln Asn Lys Val 
        755                 760                 765             


Thr Asn Ala Tyr Ile Glu Tyr Leu Glu Asn Thr Phe Ala Glu Val Ile 
    770                 775                 780                 


Asp Phe Ser Asn Phe Asn Leu Asn Phe Asp Glu Ile Lys Thr Lys Ile 
785                 790                 795                 800 


Glu Glu Arg Lys Tyr Ser Lys Ser Lys Ile Thr Val Asp Ser Ile Ser 
                805                 810                 815     


Thr Asn Ile Asn Ile Thr Asn Asp Ile Glu Tyr Ile Ile Ser Ile Phe 
            820                 825                 830         


Ala Leu Leu Asn Ser Asn Thr Tyr Ile Asn Lys Ile Arg Asn Arg Phe 
        835                 840                 845             


Phe Ala Thr Ser Val Trp Leu Asp Lys Gln Asn Ser Thr Lys Glu Tyr 
    850                 855                 860                 


Asp Tyr Glu Asn Ile Ile Asp Ile Leu Asp Lys Ile Leu Ser Ile Asn 
865                 870                 875                 880 


Leu Leu Arg Glu Asn Asn Ile Ala Asp Ile Leu Asp Leu Lys Asn Thr 
                885                 890                 895     


Ile Ile Glu Ala Lys Ile Val Glu Asn Asn Glu Glu Cys Ile Lys Asn 
            900                 905                 910         


Tyr Ile Phe Glu Asn Asn Glu Glu Glu Leu Lys Lys Arg Leu Phe Cys 
        915                 920                 925             


Glu Glu Leu Val Asn Lys Glu Asp Val Leu Lys Ile Phe Glu Asp Lys 
    930                 935                 940                 


Asn Phe Lys Phe Lys Asn Phe Ile Lys Lys Thr Gly Asn Glu Asn Phe 
945                 950                 955                 960 


Thr Ile Asn Phe Asp Ile Leu Phe Asn Leu Glu Cys Asn Ser Glu Leu 
                965                 970                 975     


Asn Val Lys Lys Val Met Gly Gln Asn Ser Gln Arg Leu Asn Leu Phe 
            980                 985                 990         


Ile Lys Asn Thr Ile Asp Glu Tyr  Lys Ser Lys Ile Lys  Thr Ser Phe 
        995                 1000                 1005             


Ser Ser  Glu Phe Leu Glu Lys  Tyr Lys Lys Glu Ile  Asp Asn Leu 
    1010                 1015                 1020             


Val Glu  Asp Thr Glu Ser Glu  Asn Lys Asn Lys Phe  Glu Lys Ile 
    1025                 1030                 1035             


Tyr Tyr  Pro Lys Glu His Lys  Asn Glu Leu Tyr Ile  Tyr Lys Lys 
    1040                 1045                 1050             


Asn Leu  Phe Leu Asn Ile Gly  Asn Pro Asn Phe Asp  Lys Ile Tyr 
    1055                 1060                 1065             


Glu Leu  Ile Ser Lys Asp Ile  Lys Asn Ala Asn Thr  Glu Ile Leu 
    1070                 1075                 1080             


Phe Asp  Asp Asp Ile Arg Lys  Asn Lys Ile Ser Glu  Ile Asp Ala 
    1085                 1090                 1095             


Ile Leu  Lys Asn Leu Asn Asp  Lys Leu Asn Gly Tyr  Ser Asn Asp 
    1100                 1105                 1110             


Tyr Lys  Ala Lys Tyr Val Asn  Lys Leu Lys Glu Asn  Asp Asp Phe 
    1115                 1120                 1125             


Phe Ala  Lys Asn Met Lys Asn  Glu Asn Tyr Ser Ser  Phe Gly Glu 
    1130                 1135                 1140             


Phe Glu  Lys Asp Tyr Asn Lys  Val Ser Glu Tyr Lys  Lys Ile Arg 
    1145                 1150                 1155             


Asp Leu  Val Glu Phe Asn Tyr  Leu Asn Lys Ile Glu  Ser Tyr Leu 
    1160                 1165                 1170             


Ile Asp  Ile Asn Trp Lys Leu  Ala Ile Gln Met Ala  Arg Phe Glu 
    1175                 1180                 1185             


Arg Asp  Met His Tyr Ile Val  Asn Gly Leu Arg Glu  Leu Gly Ile 
    1190                 1195                 1200             


Ile Lys  Leu Ser Gly Tyr Asn  Thr Gly Ile Ser Arg  Ala Tyr Pro 
    1205                 1210                 1215             


Lys Arg  Asn Gly Ser Asp Gly  Phe Tyr Thr Thr Thr  Ala Tyr Tyr 
    1220                 1225                 1230             


Lys Phe  Phe Asp Glu Glu Ser  Tyr Lys Lys Phe Glu  Lys Ile Cys 
    1235                 1240                 1245             


Tyr Gly  Phe Gly Ile Asp Leu  Ser Glu Asn Ser Glu  Ile Asn Lys 
    1250                 1255                 1260             


Pro Glu  Asn Glu Ser Ile Arg  Asn Tyr Ile Ser His  Phe Tyr Ile 
    1265                 1270                 1275             


Val Arg  Asn Pro Phe Val Asp  Tyr Ser Ile Ala Glu  Gln Ile Asp 
    1280                 1285                 1290             


Arg Val  Ser Asn Leu Leu Ser  Tyr Ser Thr Arg Tyr  Asn Asn Ser 
    1295                 1300                 1305             


Thr Tyr  Ala Ser Val Phe Glu  Val Phe Lys Lys Asp  Val Asn Leu 
    1310                 1315                 1320             


Asp Tyr  Asp Lys Leu Lys Thr  Lys Phe Lys Leu Phe  Asp Asp Glu 
    1325                 1330                 1335             


Lys Asn  Asp Asn Ile Lys Ile  Leu Lys Ile Glu Asn  Leu Ile Glu 
    1340                 1345                 1350             


Ser Lys  Lys Val Ser Val Leu  Glu Leu Glu Ser Tyr  Asn Ser Asp 
    1355                 1360                 1365             


Tyr Ile  Lys Asn Leu Ile Ile  Glu Leu Leu Thr Lys  Ile Glu Asn 
    1370                 1375                 1380             


Thr Asn  Asp Thr Leu 
    1385             


<210>  235
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  235

Met Lys Ile Thr Lys Ile Asp Gly Ile Ser His Lys Lys Tyr Ile Lys 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Lys Thr Asp Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Thr Ile Arg Leu Asp Thr Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Tyr Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Glu 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Ile Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Lys Ile Pro Tyr Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Asn Asp Lys Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Thr Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Glu Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Lys  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  236
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  236

Met Gly Thr Gly Lys Tyr Arg Ile Thr Lys Ile Gly Arg Asn Trp Lys 
1               5                   10                  15      


Glu Asn Glu Glu Thr Val Ile Leu Lys Arg Val Val Ser Asn Gly Lys 
            20                  25                  30          


Val Lys Tyr Ile Asn Glu Asn Asp Asn Val Asp Val Asn Ile Thr Glu 
        35                  40                  45              


Thr Tyr Tyr Arg Ile Leu Ser Asn Asn Lys Ala Arg Phe Leu Gly Ser 
    50                  55                  60                  


Lys Glu Gln Phe Ile Phe Lys Val Asn Lys Met Glu Arg Asn Ile Glu 
65                  70                  75                  80  


Asn Asp Cys Val Ile Ile Lys Asn Tyr Thr Glu Glu Glu Tyr Glu Lys 
                85                  90                  95      


Phe Asp Lys Lys Ile Phe Phe Lys Lys Arg Ile Lys Val Asn Asn Lys 
            100                 105                 110         


Asn Ile Glu Lys Ile Tyr Arg Asp Phe Tyr Glu Asp Glu Lys Gln Ile 
        115                 120                 125             


Met Lys Lys Arg Leu Glu Glu Ala Lys Asn Phe Asn Asn Ile Ile Phe 
    130                 135                 140                 


Asn Ile Cys Asn Lys Ile Phe Lys Leu Lys Tyr Leu Asp Tyr Thr Asn 
145                 150                 155                 160 


Glu Lys Val Tyr Lys Ile Phe Gln Asn Glu Ile Lys Val Lys Asp Ile 
                165                 170                 175     


Lys Asn Leu Lys Glu Ala Phe Lys Gln Gln Glu Lys Gly Leu Glu Thr 
            180                 185                 190         


Asp Lys Leu Leu Ala Ile Ser Phe Asn Lys Lys Arg Asn Asn Val Leu 
        195                 200                 205             


Leu Glu Phe Ile Gln Gln Ile Thr Lys Gln Glu Phe Lys Asn Gln Arg 
    210                 215                 220                 


Glu Leu Glu Asn Trp Phe Ser His Ser Gly Lys Lys Tyr Cys Lys Glu 
225                 230                 235                 240 


Ile Phe Lys Ile Tyr Ser Asn Met Ser Gln Lys Glu Lys Tyr Ser Lys 
                245                 250                 255     


Leu Leu Gly His Arg Asn Lys Asn Ile Ala Ser Ile Ser Glu Lys Lys 
            260                 265                 270         


Glu Thr Leu Gln Arg Arg Leu Lys Leu Glu Asn Tyr Ser Asp Tyr Asp 
        275                 280                 285             


Leu Arg Lys Tyr Tyr Gln Lys Asp Tyr Lys Glu Glu Ala Ile Lys Glu 
    290                 295                 300                 


Leu Lys Asp Lys Asn Lys Glu Glu Leu Glu Arg Glu Ile Glu Glu Leu 
305                 310                 315                 320 


Ile Lys Lys Asn Tyr Lys Ile Asp Lys Leu Cys Asp Glu Ile Ser Asn 
                325                 330                 335     


Leu Glu Phe Ser Phe Val Glu Ser Lys Lys Glu Asn Lys Asp Lys Met 
            340                 345                 350         


Ser Glu Ile Ile Val Lys Ile Lys Glu His Tyr Lys Lys Asn Val Asn 
        355                 360                 365             


Val Glu Glu Glu Leu Lys Asn Lys Glu Lys Tyr Ile Leu Ser Leu Ile 
    370                 375                 380                 


His Asn Tyr Val Lys Gly Arg Tyr Arg Lys Cys Leu Glu Leu Gln Gln 
385                 390                 395                 400 


Lys Glu Asn Ala Asp Phe Glu Asn Leu Gly Lys Arg Ile Lys Glu Ile 
                405                 410                 415     


Phe Asp Ser Asn Glu Val Thr Lys Lys Leu Lys Lys Ser Ile Ile Asn 
            420                 425                 430         


Lys Val Asn Ser Tyr Lys Ile Phe Glu Met Lys Phe Gln Asn Pro Asn 
        435                 440                 445             


Ile Glu Ser Ser Asp Asp Leu Glu Ile Leu Lys Ala Glu Glu Thr Phe 
    450                 455                 460                 


Leu Asn Lys Leu Ser Thr Ala Val Ser Lys Val Gly Tyr Thr Leu Asn 
465                 470                 475                 480 


Thr Leu Leu Glu Val Ser Pro Glu Lys Asp Ile Leu Glu Asn Tyr Lys 
                485                 490                 495     


Ala Val Glu Lys Leu Cys Asn Ser Asn Ser Thr Ile Glu Ile Tyr Lys 
            500                 505                 510         


Val Tyr Pro Glu Leu Glu Lys Asn Glu Lys Leu Leu Gln Gly Met Ile 
        515                 520                 525             


His Phe Ile Gln Gly Leu Arg Gln Gln Ser Leu His Pro Lys Ile Leu 
    530                 535                 540                 


Trp Asn Phe Glu Thr Lys Asn Leu Lys Pro Glu Lys Leu Glu Arg Leu 
545                 550                 555                 560 


Lys Glu Lys Lys Asn Ile Lys Met Arg Asp Cys Val Val His Glu Glu 
                565                 570                 575     


Asn Leu Asp Lys Lys Glu Lys Asn Glu Gly Glu Ile Lys Lys Tyr Phe 
            580                 585                 590         


Glu Lys Ile Glu Gly Lys Leu Pro Asp Tyr Phe Ile Glu Lys Tyr Glu 
        595                 600                 605             


Ser Asn Asn Val Phe Asn Ile Tyr Arg Asn Phe Val Asp Lys Ile Met 
    610                 615                 620                 


Glu Val Val Glu Asn Phe Asn Phe Lys Glu Asn Asn Thr Ile Asp Tyr 
625                 630                 635                 640 


Leu Phe Pro Lys Phe His Lys Ile Tyr Lys Arg Met Cys Lys Leu Glu 
                645                 650                 655     


Asn Ile Met Cys Lys Ser Glu Asn Ile Asp Asp Lys Arg Asn Gly Ala 
            660                 665                 670         


Arg Lys Tyr Leu Leu Gln Thr Ile Tyr Tyr Tyr Tyr Phe Gln Tyr Glu 
        675                 680                 685             


Ile Glu Asn Asn Lys Asn Asn Ile Ser Lys Tyr Leu Asn Leu Tyr Arg 
    690                 695                 700                 


Asn Lys Ile Glu Thr Glu Lys Asn Ser Tyr Ser Tyr Ile Ile Asp Asn 
705                 710                 715                 720 


Ile Asp Asp Ser Asn Lys Asn Ile Glu Ile Leu Tyr Arg Asn Leu Gln 
                725                 730                 735     


Arg Glu Gly Met Leu Asn Asn Lys Leu Leu Gln Ile Asn Asn Glu Trp 
            740                 745                 750         


Ile Glu Phe Ile Thr Val Gln Phe Ser Glu Phe Leu Thr Asp Lys Lys 
        755                 760                 765             


Leu Asn Trp Ile Ser Asp Glu Leu Leu Glu Tyr Glu Glu Lys Glu Lys 
    770                 775                 780                 


Leu Asp Asp Asn Asn Lys Asn Lys Leu Leu Glu Ile Leu Glu Lys Lys 
785                 790                 795                 800 


Leu Asn Lys Lys Ile Ala His Ser Asn Asp Ser Tyr Ala Phe Ile Ser 
                805                 810                 815     


Leu Ala Gln Phe Leu Asp Leu Lys Glu Ile Ser Asn Leu Ile His Asn 
            820                 825                 830         


Ile Lys Lys Phe Val Gln Phe Arg Glu Lys Asn Ile Ser Lys Tyr Lys 
        835                 840                 845             


Pro Glu Lys Asn Lys Val Tyr Ile Glu Glu Leu Arg Lys Ile Ser Tyr 
    850                 855                 860                 


Ile Leu Lys Ile Met Leu Glu His Lys Glu Arg Val Ile Gln Lys Arg 
865                 870                 875                 880 


Tyr Leu Glu Ser Tyr Ala Glu Asp Ile Ser Ile Ile Tyr Gly Lys Asp 
                885                 890                 895     


Ile Glu Lys Lys Asp Ile Lys Ala Leu Glu Ile Glu Ile Lys Lys Glu 
            900                 905                 910         


Asn Gln Gly Val Ile Gly Gln Pro Leu Tyr Lys Ser Gly Asn Asp Glu 
        915                 920                 925             


Asn Asn Ser Trp Ile Thr Leu Tyr Gly Ile Glu Gln Ala Lys Arg Asn 
    930                 935                 940                 


Gly Thr Phe Lys Phe Phe Glu Gly Phe Phe Asn Leu Asn Asp Asp Ile 
945                 950                 955                 960 


Lys Leu Cys Lys Lys Asp Ile Lys Arg Tyr Glu Lys Leu Tyr Asn Glu 
                965                 970                 975     


Lys Glu Asp Ser Gln Lys Val Val Asp Asp Tyr Ile Ser Leu Asn Glu 
            980                 985                 990         


His Ser Ser Ile Ser Thr Lys Glu  Leu Ile Lys Lys Asn  Cys Lys Lys 
        995                 1000                 1005             


Gln Leu  Phe Tyr Tyr Tyr Lys  Asn Met Ile Tyr Gly  Asp Gly Leu 
    1010                 1015                 1020             


Lys Lys  Gly Tyr Asp Phe Ile  Asn Asp Ile Tyr Ser  His Tyr Leu 
    1025                 1030                 1035             


Ser Trp  Ala Tyr Arg Ile Glu  Arg Asp Tyr Ser Ile  Tyr Lys Val 
    1040                 1045                 1050             


Glu Val  Tyr Asn Gly Lys Ile  Lys Asn Phe Arg Asn  Glu Ile Ala 
    1055                 1060                 1065             


His Phe  Asn Tyr Phe Gln Lys  Thr Asp Lys Ser Leu  Leu Asp Leu 
    1070                 1075                 1080             


Leu Asn  Asp Phe Tyr Asn Ile  Phe Asp Tyr Asn Leu  Lys Tyr Gln 
    1085                 1090                 1095             


Arg Asp  Ile Gln Lys Val Ile  Asn Asn Ile Phe Glu  Lys Tyr Gln 
    1100                 1105                 1110             


Val Val  Arg Glu Asp Gly Gly  Pro Val Ile Phe Tyr  Cys Lys Val 
    1115                 1120                 1125             


Asp Lys  Lys Leu Lys Leu Ser  Glu Asn Leu Val Pro  Lys Lys His 
    1130                 1135                 1140             


Ser Lys  Tyr Pro Glu Ile Glu  Leu Ile His Lys Lys  Tyr Val Ile 
    1145                 1150                 1155             


Phe Phe  Arg Lys Leu Phe Glu  Tyr Lys Lys 
    1160                 1165             


<210>  237
<211>  1199
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  237

Met Lys Val Thr Lys Ile Asp Gly Ile Ser His Lys Lys Phe Glu Asn 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Asp Asn Gln Gly Lys Asn Asn Glu 
            20                  25                  30          


Met Lys Glu Arg Leu Asn Lys Leu Lys Glu Leu Lys Leu Ser Asn Tyr 
        35                  40                  45              


Ile Lys Asn Pro Glu Asn Val Lys Asn Glu Asp Glu Asn Val Glu Lys 
    50                  55                  60                  


Glu Thr Lys Gln Arg Arg Lys Asn Leu Lys Asn Phe Phe Ser Glu Ile 
65                  70                  75                  80  


Ile Leu Arg Lys Glu Asn Glu Lys Tyr Val Leu Ile Lys Thr Lys Lys 
                85                  90                  95      


Phe Lys Asn Thr Asn Gln Glu Ile Asp Phe Tyr Asp Ile Lys Ser Lys 
            100                 105                 110         


Glu Lys Arg Gln Glu Ile Phe Asp Ala Leu Asn Gly Ile Leu Val Tyr 
        115                 120                 125             


Ile Glu Glu Asn Glu Lys Glu Glu Thr Ile Asn Phe Asp Ser Lys Lys 
    130                 135                 140                 


Leu Glu Lys Ala Phe Glu Asp Asp Phe Ile Lys Lys Glu Ala Lys Ile 
145                 150                 155                 160 


Lys Ala Ile Glu Lys Ser Leu Glu Ile Asn Arg Ala Asn Tyr Glu Lys 
                165                 170                 175     


Asp Tyr Val Glu Ile Glu Asn Asp Lys Tyr Ser Asp Val Lys Gly Thr 
            180                 185                 190         


Asn Lys Lys Ser Cys Val Tyr Glu Tyr Tyr Lys Lys Pro Glu Thr His 
        195                 200                 205             


Gln Lys Phe Ile Glu Asn Ile Lys Glu Ala Phe Glu Lys Leu Tyr Thr 
    210                 215                 220                 


Glu Lys Asn Ile Lys Glu Leu Leu Ser Lys Ile Glu Glu Ile Phe Asn 
225                 230                 235                 240 


Lys Thr His Leu Lys Ser Lys Val Arg Glu Phe Tyr Gln Asn Glu Ile 
                245                 250                 255     


Ile Gly Lys Ser Glu Phe Asn Lys Lys Asn Glu Glu Gly Val Ser Ile 
            260                 265                 270         


Leu Tyr Asn Gln Ile Ile Thr Ser Thr Glu Lys Lys Glu Lys Phe Thr 
        275                 280                 285             


Glu Phe Leu Lys Asn Ile Glu Leu Lys Asp Leu Thr Lys Ser Gln Val 
    290                 295                 300                 


Phe Tyr Lys Tyr Phe Leu Glu Asn Glu Glu Leu Asn Asp Glu Asn Ile 
305                 310                 315                 320 


Lys Tyr Ile Phe Cys His Phe Val Glu Ile Glu Val Asn Lys Leu Leu 
                325                 330                 335     


Lys Glu Asn Ile Tyr Lys Val Gly Lys Phe Asp Glu Val Asn Lys Asn 
            340                 345                 350         


Arg Ile Lys Asn Ile Phe Glu Tyr Arg Lys Leu Glu Asn Leu Ile Val 
        355                 360                 365             


Tyr Lys Leu Glu Asn Lys Leu Asn Thr Tyr Ile Arg Asn Cys Gly Lys 
    370                 375                 380                 


Tyr Asn Tyr His Met Glu Asn Gly Lys Met Ala Thr Ser Asp Ile Asn 
385                 390                 395                 400 


Met Lys Asn Arg Gln Thr Glu Ala Phe Leu Arg Ser Ile Ile Gly Val 
                405                 410                 415     


Ser Ser Phe Ser Tyr Phe Ser Leu Arg Asn Ile Leu Gly Val Asn Asp 
            420                 425                 430         


Asp Asp Phe Tyr Glu Ile Glu Glu Asn Ser Lys Glu Asp Glu Arg Lys 
        435                 440                 445             


Asn Glu Ser Asn Ile Leu Lys Lys Ala Lys Glu Asp Ile Thr Ser Lys 
    450                 455                 460                 


Ser Ile Phe Glu Lys Val Val Asp Lys Ser Phe Glu Lys Lys Gly Ile 
465                 470                 475                 480 


His Asn Leu Lys Glu Asn Leu Lys Met Phe Tyr Gly Asn Ser Phe Asp 
                485                 490                 495     


Glu Ala Asn Glu Glu Glu Leu Lys Gln Phe Phe Val Asn Met Leu Asn 
            500                 505                 510         


Ala Ile Thr Ser Ile Arg His Ser Ile Val His Tyr Asp Met Asn Thr 
        515                 520                 525             


Asn Ser Glu Asn Ile Phe Asn Phe Phe Asp Ile Glu Val Ser Lys Leu 
    530                 535                 540                 


Leu Lys Ser Ile Phe Glu Lys Glu Thr Asp Lys Arg Glu Leu Lys Leu 
545                 550                 555                 560 


Lys Val Phe Arg Gln Leu Asn Ser Ala Gly Val Phe Asp Tyr Trp Glu 
                565                 570                 575     


Asn Trp Lys Ile Lys Lys Tyr Leu Lys Asn Ile Glu Phe Lys Phe Ala 
            580                 585                 590         


Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys Leu Tyr Asn Arg 
        595                 600                 605             


Ile Asp Asn Leu Lys Gly Ser Asn Ala Leu Asn Leu Gly Tyr Ile Asn 
    610                 615                 620                 


Ile Pro Lys Arg Lys Glu Ala Arg Asp Ser Gln Ile Tyr Leu Leu Lys 
625                 630                 635                 640 


Asn Ile Tyr Tyr Gly Glu Phe Val Glu Lys Phe Val Asn Asn Asn Asp 
                645                 650                 655     


Asp Phe Glu Lys Ile Phe Arg Glu Ile Ile Lys Ile Asn Lys Asn Ala 
            660                 665                 670         


Gly Thr Asn Thr Lys Thr Lys Phe Tyr Lys Leu Glu Lys Phe Glu Val 
        675                 680                 685             


Leu Lys Ala Asn Thr Pro Thr Glu Tyr Leu Glu Lys Leu Gln Ser Leu 
    690                 695                 700                 


His Gln Ile Asn Tyr Asp Arg Glu Lys Ile Glu Glu Asp Lys Asp Ile 
705                 710                 715                 720 


Tyr Ile Asp Phe Val Gln Lys Ile Phe Leu Lys Gly Phe Ile Asn Tyr 
                725                 730                 735     


Leu Gln Glu Ser Asp Leu Leu Lys Pro Leu Asn Leu Leu Asn Leu Arg 
            740                 745                 750         


Lys Gly Glu Ala Ile Thr Asn Lys Lys Ser Phe Tyr Asp Glu Lys Leu 
        755                 760                 765             


Lys Leu Trp Gln Asn Asn Gly Ser Asn Leu Ser Lys Met Pro Lys Glu 
    770                 775                 780                 


Ile Tyr Asp Tyr Ile Lys Lys Ile Lys Ile Asn Lys Ile Asn Tyr Ser 
785                 790                 795                 800 


Asp Arg Met Ser Ile Phe Tyr Leu Leu Leu Lys Leu Ile Asp Tyr Arg 
                805                 810                 815     


Glu Leu Thr Asn Leu Arg Gly Asn Leu Glu Lys Tyr Glu Ser Met Asn 
            820                 825                 830         


Lys Asn Glu Ile Tyr Ser Glu Glu Leu Asn Ile Val Asn Leu Val Ser 
        835                 840                 845             


Leu Asp Asn Asn Lys Val Arg Ala Asn Phe Asn Leu Glu Pro Glu Asp 
    850                 855                 860                 


Ile Gly Lys Phe Leu Lys Thr Gly Thr Ser Ile Lys Asn Ile Asn Gln 
865                 870                 875                 880 


Leu Asn Asn Phe Ser Gly Ile Phe Ala Asp Arg Glu Asn Val Ile Lys 
                885                 890                 895     


His Arg Ser Phe Tyr Asn Ile Lys Lys Tyr Gly Ile Leu Asp Leu Leu 
            900                 905                 910         


Glu Lys Ile Val Ala Lys Ala Asp Leu Lys Ile Thr Lys Glu Glu Ile 
        915                 920                 925             


Lys Lys Tyr Lys Asn Leu Gln Lys Glu Leu Glu Lys Asn Asp Phe Tyr 
    930                 935                 940                 


Lys Ile Gln Glu Lys Ile His Arg Lys Tyr Asn Gln Lys Pro Asn Leu 
945                 950                 955                 960 


Ile Ser Lys Thr Glu Asn Glu Lys Asp Phe Asn Asp Tyr Glu Lys Ala 
                965                 970                 975     


Ile Glu Asn Ile Gln Asn Tyr Thr Gln Leu Lys Asn Lys Ile Glu Phe 
            980                 985                 990         


Asn Asp Leu Asn Leu Leu Gln Ser  Leu Leu Phe Arg Ile  Leu His Arg 
        995                 1000                 1005             


Leu Ala  Gly Tyr Thr Ser Leu  Trp Glu Arg Asp Leu  Gln Phe Lys 
    1010                 1015                 1020             


Leu Lys  Gly Glu Tyr Pro Glu  Asp Lys Tyr Ile Asp  Glu Ile Phe 
    1025                 1030                 1035             


Asn Phe  Asp Asn Ser Lys Asn  Lys Lys Tyr Lys Glu  Gly Ser Val 
    1040                 1045                 1050             


Ile Phe  Lys Tyr Ala Asp Phe  Leu Ile Glu Lys Glu  Glu Glu Lys 
    1055                 1060                 1065             


Ser Gly  Glu Ile Leu Lys Lys  Asn Lys Arg Asn Lys  Arg Arg Lys 
    1070                 1075                 1080             


Glu Ile  Ile Glu Lys Glu Gly  Leu Glu Ile Arg Asn  Tyr Ile Ala 
    1085                 1090                 1095             


His Phe  Asn Tyr Ile Pro Asp  Ala Glu Lys Ser Ile  Leu Glu Met 
    1100                 1105                 1110             


Leu Glu  Glu Leu Arg Asn Leu  Leu Lys Tyr Asp Arg  Lys Leu Lys 
    1115                 1120                 1125             


Asn Ala  Val Met Lys Ser Ile  Lys Asp Ile Phe Lys  Glu Tyr Gly 
    1130                 1135                 1140             


Phe Ile  Val Glu Phe Glu Ile  Ser His Glu Ser Asn  Ser Lys Lys 
    1145                 1150                 1155             


Ile Lys  Leu Leu Asn Val Lys  Ser Glu Lys Ile Lys  His Leu Lys 
    1160                 1165                 1170             


Asn Asn  Lys Leu Glu Thr Thr  Arg Asn Ser Glu Asp  Leu Cys Lys 
    1175                 1180                 1185             


Leu Val  Lys Val Met Leu Glu  Tyr Lys Lys Ser 
    1190                 1195                 


<210>  238
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  238

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Ile Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Phe Asp Phe Lys Leu  Leu Asn 
    1400                 1405                 1410         


<210>  239
<211>  949
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  239

Met Pro His Gln Lys Lys Met Ala Glu Arg Ile Lys Phe Val Asn Tyr 
1               5                   10                  15      


Gly Tyr Tyr Leu Arg Leu Lys Lys Asn Cys Ala Asp Ser Phe Glu Tyr 
            20                  25                  30          


Tyr Trp Cys Asp Tyr Ile Lys Glu Phe Ile Glu Glu Asn Tyr Val Thr 
        35                  40                  45              


Lys Ile Lys Glu Ala Lys Gly Lys Asn Gly Arg Gln Leu Thr Glu Glu 
    50                  55                  60                  


Asn Cys Asn Ser Glu Ala Met Leu Ser Lys Cys Trp His Asp Met Ile 
65                  70                  75                  80  


Arg His Met Cys Ala Lys Tyr Met Asp Leu Gly Lys Ala Val Tyr His 
                85                  90                  95      


Phe Met Leu Pro Gly Lys Ala Glu Gly Asn Asp Leu Cys Leu Asp Arg 
            100                 105                 110         


Leu Asn Asp Ser Phe Ser Lys Gly Ile Thr Ser Phe Asp Tyr Glu Asn 
        115                 120                 125             


Ile Lys Ala Glu Glu Asn Leu Gln Lys Ala Met Phe Gly Val Leu Val 
    130                 135                 140                 


Ser Gly Thr Phe Asn Phe Ser Arg Ser Val Ala Asp Tyr Ser Gly Pro 
145                 150                 155                 160 


Ala Ala Ala Lys Leu Ala Lys Glu Leu Arg Ala Glu Gly Lys Thr Leu 
                165                 170                 175     


Asn Glu Asp Val Leu Met Val Asp Glu Ala His Leu Lys Ala Ile Leu 
            180                 185                 190         


Tyr Ser Asp Ala Lys Arg Lys Leu Leu Arg Tyr Phe Gly Gly Ser Ser 
        195                 200                 205             


Ala Cys Glu Ala Leu Gly Leu Asp Lys Asp Lys Met Val Leu Glu Phe 
    210                 215                 220                 


Arg Gln Ile Phe Arg Gly Leu Arg Asn Ser Ala Phe His Tyr Thr Asp 
225                 230                 235                 240 


Gly Lys Lys Ala Asp Ile Lys Phe Asp Val Thr Arg Gln Leu Trp Ile 
                245                 250                 255     


Gln Asp Val Gln Ala Asn Lys Gln Leu Ile Leu Asp Lys Tyr Tyr Ser 
            260                 265                 270         


Asn Asn Val Cys Arg Tyr Tyr Lys Pro Glu Met Val Lys Lys Leu Ile 
        275                 280                 285             


Gly Asn Leu Tyr His Gly Tyr Val Glu Gln Glu Ala Gln Ile Pro Ala 
    290                 295                 300                 


Phe Arg Thr Val Trp Lys Arg Lys Asp Phe Ala Lys Tyr Leu Asn Asp 
305                 310                 315                 320 


Ser Asn Phe Leu Pro Val Asn Ile Lys Asn Asp Val Lys Glu Arg Thr 
                325                 330                 335     


Val Phe Glu Gly Ala Leu Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg 
            340                 345                 350         


Lys Tyr Thr Val Gly Gln Asp Ala Pro Lys Tyr Phe Phe Glu Ala Val 
        355                 360                 365             


Arg Ala Tyr Ser Asp Glu His Ala Lys Asn Lys Gln Asp Pro Tyr Ala 
    370                 375                 380                 


Asn Gln Ala Lys Asn Phe Trp Asp Tyr Val Glu Lys Leu Gln Lys Ser 
385                 390                 395                 400 


Tyr Glu Lys Gly Thr Leu Thr Phe Gly Ala Val Cys Gln Thr Ile Met 
                405                 410                 415     


Thr Glu Phe Val Gln Gln Asn Ser Lys Ala Thr Glu Lys Glu Gly Glu 
            420                 425                 430         


Ile Tyr Gln His Phe Lys Val Leu Phe Pro Leu Cys Met Gln Arg Gly 
        435                 440                 445             


Phe Glu Lys Tyr Val Lys Glu Lys His Gly Tyr Leu Leu Lys Pro Trp 
    450                 455                 460                 


Leu Asp Thr Val Val Arg Glu Asn Val Leu Gln Asp Ala Ala Ile Thr 
465                 470                 475                 480 


Cys Phe Asp Asp Leu Met Arg Asp Ala Glu Asp Arg Glu Tyr Ser Trp 
                485                 490                 495     


Tyr Val Val Ala His Phe Ile His Pro Lys Lys Leu Asn His Phe Val 
            500                 505                 510         


Gly Ala Leu Lys Asp Tyr Leu Gln Phe Lys Gln Asp Ile Phe Arg Arg 
        515                 520                 525             


Cys Ser Phe Ala Asn Ile Tyr Ser Glu Gly Glu Leu Ser Gln Lys Lys 
    530                 535                 540                 


Ala Met Leu Ala Glu Lys Glu Ala Glu Ile Ser Glu Ile Leu Arg Val 
545                 550                 555                 560 


Met Glu Phe Val Arg Gly Ile Thr Gly Arg Val Ser Lys Thr Phe Ser 
                565                 570                 575     


Asp Tyr Tyr Glu Asn Glu Glu Val Tyr Ala Asn Tyr Leu Gly Lys Tyr 
            580                 585                 590         


Ile Asp Phe Pro Lys Thr Asp Gly Ile Ser Val Phe Glu Ser Phe Arg 
        595                 600                 605             


Asp Phe Cys Thr Asn Thr Leu Pro Asp Gly Asn Val Leu Asp Val Tyr 
    610                 615                 620                 


Met Asp Glu Lys Asn Pro Arg Leu Leu Lys Asn Val Glu Leu Ala Arg 
625                 630                 635                 640 


Met Tyr Ala Gly Gly Asp Val Ala Leu Lys Lys Arg Lys Arg Ile Thr 
                645                 650                 655     


Ala Lys Asp Leu Gln Arg Tyr Tyr Gly Asn Glu Val Ala Val Gln Lys 
            660                 665                 670         


Ile Leu Gln Lys Gly Leu Cys Ser Thr Arg Glu Glu Gln Gln Arg Val 
        675                 680                 685             


Leu Glu Gln Gln Asn Leu Arg Gly Arg Ile Thr Leu Asn Asp Val Thr 
    690                 695                 700                 


Glu Ile Gln Glu Ile Ile Ser Asp Met Leu Ser Gln Leu Val Thr Phe 
705                 710                 715                 720 


Ser Tyr Phe Arg Glu Arg Asp Gln Met Tyr Leu Leu Leu Gly Phe Tyr 
                725                 730                 735     


Tyr Met Ala Leu Gln Thr Asn Arg Gly Ser Ser Trp Gly Asn Glu Thr 
            740                 745                 750         


Ile Asp Phe Cys Ala Gly Lys Lys Ile Ser Ile Lys Gln Gly Trp Val 
        755                 760                 765             


Leu His Gln Val Arg Ser Val Phe Thr Tyr Gly Leu Lys Leu Tyr Ser 
    770                 775                 780                 


Glu Leu Asp Glu Lys Gly Val Gly Gly Gln Leu Ser Ser Lys Ile Val 
785                 790                 795                 800 


Ala Phe Glu Arg Val His Arg Thr Ser Leu Ala Cys Ala Leu Arg Leu 
                805                 810                 815     


Phe Met Asp Glu Asn Cys Ser Arg Arg Ala Val Asp Val Arg Asn Tyr 
            820                 825                 830         


Val Asp His Phe Lys Tyr Tyr Phe Lys Ala Asp Arg Ser Ile Met Glu 
        835                 840                 845             


Leu Tyr Ser Ala Tyr Tyr Asp Cys Phe Phe Asp Tyr Ser Thr Lys Met 
    850                 855                 860                 


Arg Lys Ser Val Leu Leu Asn Phe Ile Ser Ile Leu Glu Arg His Phe 
865                 870                 875                 880 


Val Val Ser Lys Leu Arg Val Asn Cys Leu Glu Glu Arg Cys Ser Val 
                885                 890                 895     


Ser Phe Ala Glu Ser Leu Lys Ser Glu Lys Phe Thr Tyr Lys Leu Glu 
            900                 905                 910         


Ala Asp Ala Asn Lys Lys Ser Lys Glu Gln Thr Val Glu Phe Pro Ala 
        915                 920                 925             


Arg Asp Lys Glu Phe Leu Glu Ser Leu Gln Ala Glu Leu Glu Tyr Lys 
    930                 935                 940                 


Glu Gly Tyr Asn Ser 
945                 


<210>  240
<211>  1101
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  240

Met Arg Ile Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Ile Tyr Ser Glu 
            20                  25                  30          


Gln Ala Val Ser Asn Glu Thr Asn Asn Ile Leu Pro Val Lys Lys Met 
        35                  40                  45              


Asp Ser Phe Asn Leu Ser Ile Leu Asn Lys Thr Ile Ile Lys Phe Glu 
    50                  55                  60                  


Thr Val Lys Lys Gln Lys Leu Asn Leu Asp Gln Tyr Lys Ile Val Glu 
65                  70                  75                  80  


Lys Ile Phe Lys Tyr Pro Lys Gln Glu Leu Pro Lys Gln Ile Asn Ala 
                85                  90                  95      


Glu Glu Ile Leu Gln Phe Leu Asn His Lys Phe Gln Glu Pro Val Lys 
            100                 105                 110         


Tyr Trp Lys Asn Gly Lys Glu Glu Ser Phe Asn Leu Thr Leu Leu Ile 
        115                 120                 125             


Val Glu Ala Val Lys Thr Gln Glu Lys Arg Lys Leu Gln Pro Tyr Tyr 
    130                 135                 140                 


Asp Trp Lys Thr Trp Tyr Ile Gln Thr Lys Ser Asp Leu Leu Lys Lys 
145                 150                 155                 160 


Ser Ile Glu Asn Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg 
                165                 170                 175     


Lys Lys Ala Leu Leu Ala Trp Glu Thr Glu Phe Thr Thr Ser Gly Ser 
            180                 185                 190         


Ile Asp Leu Thr His Phe His Lys Val Tyr Met Thr Asp Val Leu Cys 
        195                 200                 205             


Thr Ala Leu Gln Lys Val Glu Pro Ser Ala Asp Glu Arg Gly Lys Met 
    210                 215                 220                 


Asn Ser Asn Ala Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Asn His 
225                 230                 235                 240 


Gln Pro Ala Ile Phe Gly Thr Arg Glu Ala Pro Asn Glu Val Asn Arg 
                245                 250                 255     


Ala Asp Asn Gln Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu 
            260                 265                 270         


Glu His Tyr Phe Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Ala Asp 
        275                 280                 285             


Asp Ile Ser His Tyr Leu Lys Ala Gln Thr Leu Lys Thr Thr Ile Glu 
    290                 295                 300                 


Lys Gln Leu Val Asn Ala Ile Arg Ala Asn Ile Ile Gln Gln Gly Lys 
305                 310                 315                 320 


Thr Asn His His Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile 
                325                 330                 335     


Arg Ile Lys Thr Asn Glu Ala Phe Val Leu Asn Leu Ile Gly Thr Cys 
            340                 345                 350         


Ala Phe Ala Ala Asn Asn Ile Arg Asn Met Val Asp Lys Glu Gln Ile 
        355                 360                 365             


Ser Asp Ile Leu Gly Lys Arg Glu Phe Ile Asp Ser Leu Thr Lys Ser 
    370                 375                 380                 


Arg Ile Ser Ser Gln Leu Tyr Ser Phe Phe Phe Gly Glu Asn Leu Ser 
385                 390                 395                 400 


Thr Asn Lys Ala Glu Lys Glu Thr Gln Leu Trp Gly Ile Arg Gly Ala 
                405                 410                 415     


Val Gln Gln Ile Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu 
            420                 425                 430         


Thr Thr Ile Phe Asn Ile Cys Lys Phe Glu Asn Pro Thr Asp Ala Asp 
        435                 440                 445             


Pro Lys Gln Gln Thr Asn Tyr Val Asp Ser Ile Tyr Lys Thr Leu Phe 
    450                 455                 460                 


Ile Lys Glu Leu Glu Lys Ile Pro Glu Ala Phe Ala Gln Gln Leu Lys 
465                 470                 475                 480 


Thr Gly Gly Ala Leu Ser Tyr Tyr Thr Val Glu Asn Leu Lys Thr Leu 
                485                 490                 495     


Leu Thr Thr Phe Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala 
            500                 505                 510         


Pro Gly Phe Lys Lys Val Leu Asn Gly Gly Ile Asn Tyr Gln Asn Ala 
        515                 520                 525             


Lys Gln Asp Glu Ser Phe Tyr Glu Leu Met Leu Glu Arg Tyr Leu Arg 
    530                 535                 540                 


Lys Glu Asn Phe Ala Glu Glu Ala Tyr Asn Ala Arg Tyr Phe Leu Leu 
545                 550                 555                 560 


Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Lys Phe Thr Ala Asp Arg 
                565                 570                 575     


Lys Ala Phe Ala Asp Ser Val Gly Phe Val Gln Leu Gln Asn Arg Lys 
            580                 585                 590         


Gln Ala Glu Asn Ser Lys Arg Pro Lys Ala Phe Ala Phe Glu Ala Val 
        595                 600                 605             


Arg Pro Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala Tyr Val 
    610                 615                 620                 


Gln Ser Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys Ala Thr 
625                 630                 635                 640 


Asp Glu Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val Phe Ile 
                645                 650                 655     


Lys Gly Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe Val Gln 
            660                 665                 670         


Val Pro Gln Pro Gln Leu Thr Thr Thr Asp Ser Asn Gln Gln Lys Ala 
        675                 680                 685             


Asp Lys Leu Asn Gln Leu Glu Ala Ser Ile Thr Ala Asp Cys Lys Leu 
    690                 695                 700                 


Thr Ala Gln Tyr Ala Lys Thr Asp Asp Ala Thr His Ile Ala Phe Tyr 
705                 710                 715                 720 


Val Phe Cys Lys Leu Leu Asp Ala Gly His Leu Ser Asn Leu Arg Asn 
                725                 730                 735     


Glu Leu Ile Lys Phe Arg Gly Ser Val Lys Asp Phe Asp Phe His His 
            740                 745                 750         


Leu Leu Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val Val Pro 
        755                 760                 765             


Thr Asp Tyr Arg Asp Leu Tyr Ser Ser Gly Ala Asp Cys Leu Ala Arg 
    770                 775                 780                 


Leu Arg Pro Phe Ile Glu Gln Gly Ala Asp Ile Lys Asn Trp Ser Asp 
785                 790                 795                 800 


Leu Tyr Val Gln Thr Asp Lys Gln Thr Pro Val Ile His Ala Gly Ile 
                805                 810                 815     


Glu Leu Ser Val Lys Tyr Gly Thr Thr Ala Leu Leu Glu Gln Leu Ile 
            820                 825                 830         


Thr Cys Asn Pro Lys Phe Arg Val Met Glu Asp Asn Phe Thr Lys Trp 
        835                 840                 845             


Ser Ala Gln Lys Lys Glu Ile Glu Glu Lys Val Asn Lys His Thr Asn 
    850                 855                 860                 


Leu His Gln Gln Trp Val Glu Ala Lys Glu Lys Asp Asp Arg Glu Arg 
865                 870                 875                 880 


Val Lys Ser Lys Lys Asn Phe Val Arg Glu Tyr Val Lys Lys Asn Tyr 
                885                 890                 895     


Val Asp Tyr Ile Asn Asn Cys Ile Glu Ile Asn Asn Tyr Asn Trp Leu 
            900                 905                 910         


Asp Asn Lys Leu His Phe Val His Leu Asn His Leu His His Leu Thr 
        915                 920                 925             


Ile Asp Ile Leu Gly Arg Met Ala Gly Phe Val Ala Leu Trp Glu Arg 
    930                 935                 940                 


Asp Phe Gln Tyr Ile Thr Lys Tyr Thr Ala Ala Lys Glu Gly Thr Asp 
945                 950                 955                 960 


Ala Leu Ser Phe Asp Gly Gly Leu Pro Arg Leu Lys Asp Lys Gln Glu 
                965                 970                 975     


Tyr Tyr Asn Lys Leu Phe Leu Ser Asp Lys Tyr Thr Lys Val Arg Asn 
            980                 985                 990         


His Ile Ala His Phe Asn Tyr Leu  Thr Lys Asp Ala Ala  Asp Phe Ala 
        995                 1000                 1005             


Leu Leu  Asp Leu Ile Asn Glu  Leu Arg Glu Leu Leu  His Tyr Gly 
    1010                 1015                 1020             


Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ala Phe Ile  Asp Leu Phe 
    1025                 1030                 1035             


Glu Lys  His Gly Met Ile Leu  Lys Leu Lys Leu Asn  Thr Asp His 
    1040                 1045                 1050             


Gln Leu  Val Val Glu Ser Ile  Glu Pro Lys Lys Ile  Tyr His Leu 
    1055                 1060                 1065             


Gly Ser  Thr Ala Lys Asp Lys  Pro Glu Tyr Gln Tyr  Thr Thr Asn 
    1070                 1075                 1080             


Gln Val  Met Thr Val Tyr Cys  Asn Met Cys Arg Ser  Leu Leu Glu 
    1085                 1090                 1095             


Met Lys  Lys 
    1100     


<210>  241
<211>  1330
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  241

Met Lys Arg Glu Glu Asn Ile Thr Ile Met Lys Ile Ser Lys Val Asn 
1               5                   10                  15      


His Arg Arg Thr Ala Val Ala Leu Asn Gly Asp Lys Ser Glu Leu Gly 
            20                  25                  30          


Gly Ile Leu Tyr Glu Ala Pro Val Gln Lys Asp Lys Asn Gly Asn Tyr 
        35                  40                  45              


Asn Asp Val Ile Ala Glu Thr Gly Lys Val Val Asn Glu Ala Leu Asp 
    50                  55                  60                  


Lys Lys Ser Arg Leu Tyr Thr Pro Phe Asn Asn Gln Lys Val Ile Ile 
65                  70                  75                  80  


Asp Lys Asn Leu Gln Arg Tyr Ala Asn Asn Leu Lys Arg Cys Tyr Ile 
                85                  90                  95      


Asn Phe Val Lys Gln Tyr Val Asn Asn Lys Ser Phe Asn Tyr Lys Ala 
            100                 105                 110         


Met Gln Phe Ile Pro Asp Ile Gln Asn Pro Lys Thr Asn Asp Glu Val 
        115                 120                 125             


Asn Tyr Arg Thr Asp Arg Asp Asn Val Tyr Asn Lys Asn Lys Tyr Tyr 
    130                 135                 140                 


Asp Lys Gln Thr Lys Ser Lys Ser Lys Lys Phe Ile Tyr Glu Lys Ile 
145                 150                 155                 160 


Val Ile Pro Gln Asn Glu Gln Asn Ile Val Ile Ser Ala Leu Val Asn 
                165                 170                 175     


Cys Ser Leu Arg Lys Ser Leu Arg Lys Asp Val Ser Tyr Lys Thr Lys 
            180                 185                 190         


Ser Gly Glu Ile Lys Thr Tyr Asn Leu Pro Glu Leu Val Lys Lys Ser 
        195                 200                 205             


Met Arg Phe Tyr Cys Leu Glu Gly Gln Arg Glu Pro Asp Glu Lys Glu 
    210                 215                 220                 


Lys Tyr Glu Met Tyr Ile Leu Phe Ser Tyr Met Lys Glu Asp Lys Arg 
225                 230                 235                 240 


Thr Lys Asn Thr Asp Leu Leu Val Lys Ser Ile Ser Asn Gln Asn Thr 
                245                 250                 255     


Lys Val Lys Val Glu Asp Ile Asp Gly Asn Lys Leu Leu Lys Leu Ser 
            260                 265                 270         


Ile Ala Asp Thr Lys Lys Lys Pro Leu Trp Glu Tyr Leu Ile Lys Tyr 
        275                 280                 285             


Ala Asp Ser Ser Arg Gln Arg Glu Leu Met Tyr Asp Ile Arg Lys Lys 
    290                 295                 300                 


Ile Ile Leu Tyr Val Ala Gly Ile Glu Glu Tyr Glu Asn Ile Lys Glu 
305                 310                 315                 320 


Asp Ser Gly Leu Ser Lys Val Ser Trp Ser Lys Tyr Asn Ile Ser Asp 
                325                 330                 335     


Asn Lys Met Phe Phe Asp Ile Asn Ser Cys Thr Asp Lys Arg Lys Gln 
            340                 345                 350         


Asn Leu Glu Ile Lys Ile Arg Glu Ala Asn Ile Glu His Tyr Arg Asn 
        355                 360                 365             


Ala Ser Ser Lys Leu Cys Asp Asp Glu Ser Ile Phe Trp Phe Gln His 
    370                 375                 380                 


Phe Glu Gly Val Ile Glu Thr Leu Phe Ser Lys Lys Ser Lys Ile Ser 
385                 390                 395                 400 


Glu Glu Arg Leu Gly Cys Ala Tyr Ile Cys Asp Tyr Leu Trp Lys Asp 
                405                 410                 415     


Phe Leu Ser Tyr Leu Ala Ala Lys Tyr Ile Asp Leu Gly Lys Gly Val 
            420                 425                 430         


Tyr His Phe Thr Met Lys Asp Lys Leu Asp Met Leu Asn Lys Asn Glu 
        435                 440                 445             


Ala Val Thr Asp Leu Arg Phe Gly Ile Val Ser Glu Lys Tyr Glu Lys 
    450                 455                 460                 


Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Glu Leu 
465                 470                 475                 480 


Asp Arg Asn Ile Ala Ala Tyr Val Thr Phe Ala Ala Asp Ile Phe Ala 
                485                 490                 495     


Lys Ser Val Ile Lys Ser Asp Tyr Arg Thr Lys Lys Asp Asn Asn Ser 
            500                 505                 510         


Asp Val Leu Gln Tyr Ser Asp Lys Glu Phe Arg Asn Ser Glu Val Ile 
        515                 520                 525             


Arg Asp Asn Ala Glu Lys Asn Ile Leu Gln Tyr Trp Gly Gly Tyr Ser 
    530                 535                 540                 


Arg Trp Gly Thr Glu Asn Ser Lys Leu Pro Glu Asn Asn Lys Val Ser 
545                 550                 555                 560 


Asp Phe Gly Lys Leu Asn Val Ser Asp Leu Cys Ile Asp Ile Lys Lys 
                565                 570                 575     


His Leu Ala Gly Ile Arg Asn Ser Ser Val His Tyr Thr Thr Lys Ile 
            580                 585                 590         


Lys Asn Glu Ser Ala Ala Asp Gly Ser Asn Val Lys Ile Leu Phe Glu 
        595                 600                 605             


Lys Asp Leu Ala Asp Ile Asn Ile Ile Tyr Ala Asp Lys Tyr Tyr Ser 
    610                 615                 620                 


Asn Asn Val Trp Met Phe Tyr Ser Leu Glu Asp Ile Asn Lys Leu Ile 
625                 630                 635                 640 


Ala Phe Leu Tyr Lys Glu Lys Arg Val Ile Arg Gln Val Gln Ile Pro 
                645                 650                 655     


Ser Phe Ser Arg Ile Leu Lys Arg Lys Ala Met Gln Asp Val Ile Asn 
            660                 665                 670         


Glu Ile Phe Lys Asp Asp Phe Asp Glu Asn Ile Val Asn Pro Glu Leu 
        675                 680                 685             


Lys Glu Lys Tyr Arg Asn Ser Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
    690                 695                 700                 


Tyr Asn Ala Phe Ile Ile Gln Pro Glu Leu Lys Glu Lys Phe Lys Asp 
705                 710                 715                 720 


Lys Ile Lys Thr Met Lys Ser Glu Leu Tyr Asn Lys Leu Lys Thr Ile 
                725                 730                 735     


Asp Lys Lys Glu Tyr Lys Ala Leu Tyr Cys Met Leu Ser Asn Glu Glu 
            740                 745                 750         


Ser Ala Leu Lys Asn Phe Ala Asp Arg Ile Tyr Ser Val Asp Gly Asp 
        755                 760                 765             


Asn Val Ser Phe Ala Asp Ile Cys Lys Ile Leu Met Thr Asp Tyr Asn 
    770                 775                 780                 


Met Gln Asn Gln Glu Lys Lys Asn Ile Glu Ser Met Glu Gln Lys Lys 
785                 790                 795                 800 


Lys Asn Lys Gly Lys Asp Glu Asn Tyr Lys His Phe Pro Leu Leu Leu 
                805                 810                 815     


His Lys Val Leu Lys Glu Leu Phe Ile Glu Tyr Leu Lys Gln Thr His 
            820                 825                 830         


Glu Leu Glu Phe Leu Arg Asn Asn Ile Cys Ile Lys Ser Asp Val Thr 
        835                 840                 845             


Met Glu Ser Phe Glu Ser Gln Ile Lys Gly Val Glu Ile Tyr Lys Asp 
    850                 855                 860                 


Leu Lys Glu Lys Ile Asp Lys Asn Asn Ser Leu Leu Asp Trp Tyr Val 
865                 870                 875                 880 


Ile Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asn 
                885                 890                 895     


Ile Lys Asn Tyr Ile Gln Phe Ala Thr Asn Ile Asp Lys Arg Ala Glu 
            900                 905                 910         


Ser Val Lys Asn Leu Thr Glu Ser Gly Met Val Lys Arg Ile Gln Tyr 
        915                 920                 925             


Tyr Asp Asp Ile Val Arg Thr Leu Glu Phe Ser Ala Gln Tyr Ile Gly 
    930                 935                 940                 


Lys Ile Ser Asn Asn Ile Asn Asp Tyr Phe Asn Ser Glu Asp Glu Tyr 
945                 950                 955                 960 


Val Ser Phe Leu Ser Lys Tyr Val Gly Phe Ile Asn Asp Lys Ser Glu 
                965                 970                 975     


Asp Val Leu Thr Glu Leu Lys Asp Phe Cys Arg Glu Lys Ile Asn Asn 
            980                 985                 990         


Gly Ser Gln Ile Ile Gly Ile Tyr  Tyr Gly Gly Asp Asn  Val Ile Ile 
        995                 1000                 1005             


Asn Arg  Asn Val Ile Tyr Ala  Gln Met Tyr Ser Asn  Ala Glu Val 
    1010                 1015                 1020             


Phe Ser  Asn Ile Tyr Lys Lys  Val Thr Lys Asn Asp  Ile Ile Asn 
    1025                 1030                 1035             


Tyr Tyr  Glu Lys Gln Asn Asp  Leu Lys Asp Val Phe  Lys Ser Gly 
    1040                 1045                 1050             


Val Cys  Gln Asn Glu Gly Glu  Gln Arg Ser Leu Cys  Glu Phe Gln 
    1055                 1060                 1065             


Gln Leu  Lys Asn Arg Thr Glu  Leu Thr Glu Leu Ser  Thr Tyr Ala 
    1070                 1075                 1080             


Asp Met  Val Asn Asp Phe Met  Ala Gln Phe Val Glu  Trp Ala Tyr 
    1085                 1090                 1095             


Leu Arg  Glu Arg Asp Leu Met  Tyr Phe Gln Leu Gly  Ile His Tyr 
    1100                 1105                 1110             


Ile Arg  Leu Phe Tyr Ser Asp  Asn Ala Leu Asp Glu  Lys Tyr His 
    1115                 1120                 1125             


Lys Leu  Ser Asp Asn Val Ile  Asp Ile Glu Glu Gly  Ala Leu Leu 
    1130                 1135                 1140             


Tyr Gln  Ile Val Ala Met Tyr  Asp Tyr Glu Leu Arg  Ile Phe Glu 
    1145                 1150                 1155             


Thr Asp  Asn Ser Gly Asn Ala  Lys Arg Ile Gly Gln  Gly Gly Pro 
    1160                 1165                 1170             


Gly Lys  Ser Ile Pro Val Phe  Leu Lys Lys Tyr Cys  Asn Gly Thr 
    1175                 1180                 1185             


Asp Val  Tyr Glu Cys Gly Leu  Glu Leu Phe Glu Asp  Ile Asn Gln 
    1190                 1195                 1200             


His Glu  His Ile Ile Arg Phe  Arg Asn Asp Ile Ala  His Met Arg 
    1205                 1210                 1215             


Tyr Met  Ser Asn Gln Ala Met  Asn Ile Met Ser Ile  Val Ser Asn 
    1220                 1225                 1230             


Ile Tyr  Lys Ser Phe Phe Val  Tyr Asp Thr Lys Leu  Lys Lys Ser 
    1235                 1240                 1245             


Ile Ser  Leu Val Phe Lys Asn  Ile Leu Met Arg Tyr  Gly Val Ile 
    1250                 1255                 1260             


Ala Asp  Leu Val Phe Ser Tyr  Asn Asn Lys Asn Gln  Ser Ile Lys 
    1265                 1270                 1275             


Asp Asp  Met Asp Ile Asn Ile  Ile Asn Ile Lys Asn  Leu Lys Ser 
    1280                 1285                 1290             


Asp Lys  Tyr Val Tyr Lys Ile  Val Asn Glu Asp Ile  Val Lys Gln 
    1295                 1300                 1305             


Val Glu  Ile Glu Ile Arg Asn  Gln Val Phe Leu Glu  Gln Leu His 
    1310                 1315                 1320             


Asn Leu  Leu Tyr Phe Ser Arg  
    1325                 1330 


<210>  242
<211>  1101
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  242

Met Arg Ile Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Ile Tyr Ser Glu 
            20                  25                  30          


Gln Ala Val Ser Asn Glu Thr Asn Asn Ile Leu Pro Val Lys Lys Met 
        35                  40                  45              


Asp Ser Phe Asn Leu Ser Ile Leu Asn Lys Thr Ile Ile Lys Phe Glu 
    50                  55                  60                  


Thr Val Lys Lys Gln Lys Leu Asn Leu Asp Gln Tyr Lys Ile Val Glu 
65                  70                  75                  80  


Lys Ile Phe Lys Tyr Pro Lys Gln Glu Leu Pro Lys Gln Ile Asn Ala 
                85                  90                  95      


Glu Glu Ile Leu Gln Phe Leu Asn His Lys Phe Gln Glu Pro Val Lys 
            100                 105                 110         


Tyr Trp Lys Asn Gly Lys Glu Glu Ser Phe Asn Leu Thr Leu Leu Ile 
        115                 120                 125             


Val Glu Ala Val Lys Thr Gln Glu Lys Arg Lys Leu Gln Pro Tyr Tyr 
    130                 135                 140                 


Asp Trp Lys Ala Trp Tyr Ile Gln Thr Lys Ser Asp Leu Leu Lys Lys 
145                 150                 155                 160 


Ser Ile Glu Asn Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg 
                165                 170                 175     


Lys Lys Ala Leu Leu Ala Trp Glu Thr Glu Phe Thr Thr Ser Gly Ser 
            180                 185                 190         


Ile Asp Leu Thr His Phe His Lys Val Tyr Met Thr Asp Val Leu Cys 
        195                 200                 205             


Thr Ala Leu Gln Lys Val Glu Pro Ser Ala Asp Glu Arg Gly Lys Met 
    210                 215                 220                 


Asn Ser Asn Ala Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Asn His 
225                 230                 235                 240 


Gln Pro Ala Ile Phe Gly Thr Arg Glu Ala Pro Asn Glu Val Asn Arg 
                245                 250                 255     


Ala Asp Asn Gln Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu 
            260                 265                 270         


Glu His Tyr Phe Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Ala Asp 
        275                 280                 285             


Asp Ile Ser His Tyr Leu Lys Ala Gln Thr Leu Lys Thr Thr Ile Glu 
    290                 295                 300                 


Lys Gln Leu Val Asn Ala Ile Arg Ala Asn Ile Ile Gln Gln Gly Lys 
305                 310                 315                 320 


Thr Asn His His Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile 
                325                 330                 335     


Arg Ile Lys Thr Asn Glu Ala Phe Val Leu Asn Leu Ile Gly Thr Cys 
            340                 345                 350         


Ala Phe Ala Ala Asn Asn Ile Arg Asn Met Val Asp Lys Glu Gln Ile 
        355                 360                 365             


Ser Asp Ile Leu Gly Lys Arg Glu Phe Ile Asp Ser Leu Thr Lys Ser 
    370                 375                 380                 


Arg Ile Ser Ser Gln Leu Tyr Ser Phe Phe Phe Gly Glu Asn Leu Ser 
385                 390                 395                 400 


Thr Asn Lys Ala Glu Lys Glu Thr Gln Leu Trp Gly Ile Arg Gly Ala 
                405                 410                 415     


Val Gln Gln Ile Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu 
            420                 425                 430         


Thr Thr Ile Phe Asn Ile Cys Lys Phe Glu Asn Pro Thr Asp Ala Asp 
        435                 440                 445             


Pro Lys Gln Gln Thr Asn Tyr Val Asp Ser Ile Tyr Lys Thr Leu Phe 
    450                 455                 460                 


Ile Lys Glu Leu Glu Lys Ile Pro Glu Ala Phe Ala Gln Gln Leu Lys 
465                 470                 475                 480 


Thr Gly Gly Ala Leu Ser Tyr Tyr Thr Val Glu Asn Leu Lys Thr Leu 
                485                 490                 495     


Leu Thr Thr Phe Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala 
            500                 505                 510         


Pro Gly Phe Lys Lys Val Leu Asn Gly Gly Ile Asn Tyr Gln Asn Ala 
        515                 520                 525             


Lys Gln Asp Glu Ser Phe Tyr Glu Leu Met Leu Glu Arg Tyr Leu Arg 
    530                 535                 540                 


Lys Glu Asn Phe Ala Glu Glu Ala Tyr Asn Ala Arg Tyr Phe Leu Leu 
545                 550                 555                 560 


Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Lys Phe Thr Ala Asp Arg 
                565                 570                 575     


Lys Ala Phe Ala Asp Ser Val Gly Phe Val Gln Leu Gln Asn Arg Lys 
            580                 585                 590         


Gln Ala Glu Asn Ser Lys Arg Pro Lys Ala Phe Ala Phe Glu Ala Val 
        595                 600                 605             


Arg Pro Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala Tyr Val 
    610                 615                 620                 


Gln Ser Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys Ala Thr 
625                 630                 635                 640 


Asp Glu Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val Phe Ile 
                645                 650                 655     


Lys Gly Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe Val Gln 
            660                 665                 670         


Val Pro Gln Pro Gln Leu Thr Thr Thr Asp Ser Asn Gln Gln Lys Ala 
        675                 680                 685             


Asp Lys Leu Asn Gln Leu Glu Ala Ser Ile Thr Ala Asp Cys Lys Leu 
    690                 695                 700                 


Thr Ala Gln Tyr Ala Lys Thr Asp Asp Ala Thr His Ile Ala Phe Tyr 
705                 710                 715                 720 


Val Phe Cys Lys Leu Leu Asp Ala Gly His Leu Ser Asn Leu Arg Asn 
                725                 730                 735     


Glu Leu Ile Lys Phe Arg Gly Ser Val Lys Asp Phe Asp Phe His His 
            740                 745                 750         


Leu Leu Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val Val Pro 
        755                 760                 765             


Thr Asp Tyr Arg Asp Leu Tyr Ser Ser Gly Ala Asp Cys Leu Ala Arg 
    770                 775                 780                 


Leu Arg Pro Phe Ile Glu Gln Gly Ala Asp Ile Lys Asn Trp Ser Asp 
785                 790                 795                 800 


Leu Tyr Val Gln Thr Asp Lys Gln Thr Pro Val Ile His Ala Gly Ile 
                805                 810                 815     


Glu Leu Ser Val Lys Tyr Gly Thr Thr Ala Leu Leu Glu Gln Leu Ile 
            820                 825                 830         


Thr Cys Asn Pro Lys Phe Arg Val Met Glu Asp Asn Phe Thr Lys Trp 
        835                 840                 845             


Ser Ala Gln Lys Lys Glu Ile Glu Glu Lys Val Asn Lys His Thr Asn 
    850                 855                 860                 


Leu His Gln Gln Trp Val Glu Ala Lys Glu Lys Asp Asp Arg Glu Arg 
865                 870                 875                 880 


Val Lys Ser Lys Lys Asn Phe Val Arg Glu Tyr Val Lys Lys Asn Tyr 
                885                 890                 895     


Val Asp Tyr Ile Asn Asn Cys Ile Glu Ile Asn Asn Tyr Asn Trp Leu 
            900                 905                 910         


Asp Asn Lys Leu His Phe Val His Leu Asn His Leu His His Leu Thr 
        915                 920                 925             


Ile Asp Ile Leu Gly Arg Met Ala Gly Phe Val Ala Leu Trp Glu Arg 
    930                 935                 940                 


Asp Phe Gln Tyr Ile Thr Lys Tyr Thr Ala Ala Lys Glu Gly Thr Asp 
945                 950                 955                 960 


Ala Leu Ser Phe Asp Gly Gly Leu Pro Arg Leu Lys Asp Lys Gln Glu 
                965                 970                 975     


Tyr Tyr Asn Lys Leu Phe Leu Ser Asp Lys Tyr Thr Lys Val Arg Asn 
            980                 985                 990         


His Ile Ala His Phe Asn Tyr Leu  Thr Lys Asp Ala Ala  Asp Phe Ala 
        995                 1000                 1005             


Leu Leu  Asp Leu Ile Asn Glu  Leu Arg Glu Leu Leu  His Tyr Gly 
    1010                 1015                 1020             


Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ala Phe Ile  Asp Leu Phe 
    1025                 1030                 1035             


Glu Lys  His Gly Met Ile Leu  Lys Leu Lys Leu Asn  Thr Asp His 
    1040                 1045                 1050             


Gln Leu  Val Val Glu Ser Ile  Glu Pro Lys Lys Ile  Tyr His Leu 
    1055                 1060                 1065             


Gly Ser  Thr Ala Lys Asp Lys  Pro Glu Tyr Gln Tyr  Thr Thr Asn 
    1070                 1075                 1080             


Gln Val  Met Thr Val Tyr Cys  Asn Met Cys Arg Ser  Leu Leu Glu 
    1085                 1090                 1095             


Met Lys  Lys 
    1100     


<210>  243
<211>  1284
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  243

Met Ile Ile Gly Gly Ile Asn Met Lys Leu Thr Arg Arg Arg Ile Ser 
1               5                   10                  15      


Gln Glu Arg Lys Asn Gln Lys Leu Thr Ala Ala Phe Tyr Arg Asp Met 
            20                  25                  30          


Asp His Gly Leu Leu Tyr Val Asp Ser Glu Asp Glu Asp Arg Thr Glu 
        35                  40                  45              


Tyr Val Val Ser Ser Met Asp Phe Glu Arg Ser Trp Arg Gly Arg Ile 
    50                  55                  60                  


Leu Lys Asn Gly Glu Asp Asn Lys Asn Pro Phe Tyr Glu Phe Val Lys 
65                  70                  75                  80  


Gly Leu Val Gly Ser Asn Glu Ile Ile Cys Lys Pro Ile Thr Asn Asp 
                85                  90                  95      


Asn Asn Thr Asp Ile Asn Glu Lys Ile Lys Lys Tyr Ile Thr Glu Phe 
            100                 105                 110         


Gly Arg Asn Leu Lys Ala Pro Gly Ser Glu Val Thr Leu Glu Lys Leu 
        115                 120                 125             


Ile Leu Asn Ile Gln Ser Gly Thr Ser Glu Asn Glu Val Arg Pro Glu 
    130                 135                 140                 


Leu Glu Lys Ile Lys Asp Met Ile Lys Lys Asp Ile Glu Lys Arg Lys 
145                 150                 155                 160 


Asp Glu Leu Ile Lys Ser Ile Thr Asn Asn His Ile Pro Phe Met Leu 
                165                 170                 175     


Asp Glu Asp Lys Leu Val Pro Ser Thr Lys Lys Met Lys Trp Leu Tyr 
            180                 185                 190         


Lys Phe Leu Asn Gly Pro Asp Lys Ser Leu Asn Leu Gln Met Phe Asp 
        195                 200                 205             


Glu Tyr Trp Thr Lys Tyr Gly Tyr Lys Asn Leu Glu Glu Lys Ile Ile 
    210                 215                 220                 


Lys Glu Ile Asn Ser Leu Pro Glu Lys Asn Ala Arg Ser Ile Ser Arg 
225                 230                 235                 240 


Ala Val Ser Lys Thr Val Arg Glu Tyr Asn Arg Asn Phe Arg Ile Asn 
                245                 250                 255     


Tyr Met Val Pro Glu Asn Glu Asn Ala Glu Ala Asp Ser Asp Tyr Glu 
            260                 265                 270         


Gly Phe Leu Leu Phe Leu Lys Ala Val Glu Gln His Phe Lys Lys Tyr 
        275                 280                 285             


Tyr Pro Val Lys Ser Lys Asp Ser Asn Glu Val Arg Asp Lys Asn Leu 
    290                 295                 300                 


Cys Glu Glu Lys Asn Tyr Lys Phe Tyr Cys Ser Tyr Asn Phe Val Lys 
305                 310                 315                 320 


Asn Glu Val Lys Arg Ser Ile Ile Asn Gln Leu Val Ser Gly Leu Ile 
                325                 330                 335     


Gln Gln Gly Lys Leu Leu His Tyr Phe Tyr Lys Asp Gly Ile Trp Gln 
            340                 345                 350         


Gln Asp Phe Leu Asn Ser Tyr Gly Leu Ser Tyr Ile Gln Val Glu Glu 
        355                 360                 365             


Ser Phe Lys Lys Ser Leu Met Thr Ser Leu Ser Trp Gly Ile Asn Arg 
    370                 375                 380                 


Leu Thr Ser Phe Phe Ile Asp Val Gly Thr Asp Glu Asn Glu Glu Lys 
385                 390                 395                 400 


Thr Val Gln Asn Lys Lys Gln Lys Asn Asn Arg Lys Ile Asp Asp Ile 
                405                 410                 415     


Leu Ser Asp Lys Ser Asn Leu Arg Ala Ile Phe Asn Asp Leu Arg Ser 
            420                 425                 430         


Asn Thr Glu Leu Gln Lys His Phe Lys Glu Lys Leu Ala Phe Cys Tyr 
        435                 440                 445             


Pro Ile Phe Ile Lys Val Lys Lys Glu Lys Met Phe Asp Asp Ile Glu 
    450                 455                 460                 


Lys Leu Ile Lys Leu Val Glu Glu Ala Arg Glu Ser Val Ala Tyr Leu 
465                 470                 475                 480 


Arg His Arg Cys Phe His Tyr Lys Asp Val Thr Ile Thr Glu Met Leu 
                485                 490                 495     


Lys Ala Leu Asn Asn Asn Thr Glu Thr Asp Lys Thr Glu Asp Ile Asp 
            500                 505                 510         


Tyr Ser Val Ala Ala Glu Tyr Phe Leu Arg Asp Ile Asn Asn Leu Tyr 
        515                 520                 525             


Asp Ala Phe Arg Glu Gln Ile Arg Ser Ser Gly Ile Ala Asp Tyr Tyr 
    530                 535                 540                 


Pro Ala Asp Ile Ile Ser Gly Cys Phe Lys Lys Cys Gly Leu Gln Phe 
545                 550                 555                 560 


Val Leu Tyr Ser Pro Gln Asn Ser Leu Met Pro Ser Phe Lys Asn Ile 
                565                 570                 575     


Tyr Lys Arg Gly Ser Asn Leu Tyr Lys Ala Tyr Gln Glu Glu Lys Glu 
            580                 585                 590         


Gln Lys Asp Lys Glu Tyr Lys Arg His Asn Thr Asn Ile Val Gln Glu 
        595                 600                 605             


Glu Ser Lys Glu Leu Ser Trp Tyr Ile Glu Val Ser Asp Thr Glu Gln 
    610                 615                 620                 


Gly Lys Thr Ala Tyr Arg Asn Leu Leu Gln Leu Ile Tyr Tyr His Ala 
625                 630                 635                 640 


Phe Leu Pro Glu Val Arg Glu Asn Glu Ser Leu Ile Thr Val Tyr Phe 
                645                 650                 655     


Ala Lys Thr Lys Glu Trp Asn Arg Lys Val Ala Glu Thr Lys Ala Lys 
            660                 665                 670         


Lys Lys Asn Ala Gly Lys Thr Tyr Lys Asp Lys Pro Ile Arg Ala Tyr 
        675                 680                 685             


Arg Tyr Glu Ala Ile Pro Asp Tyr Val Gly Glu Arg Leu Asp Asp Tyr 
    690                 695                 700                 


Phe Lys Ile Leu Gln Arg Glu Gln Met Ala Lys Ala Lys Asp Val Asn 
705                 710                 715                 720 


Glu Gly Asn Ala Glu Asn Asn Asn Tyr Ile Gln Phe Ile Arg Asp Val 
                725                 730                 735     


Val Val Trp Ala Phe Gly Ala Tyr Leu Glu Glu Arg Leu Glu Lys Tyr 
            740                 745                 750         


Lys Lys Asp Leu Gln Ser Ser His Ser Gln Lys Asp Lys Lys Asp Val 
        755                 760                 765             


Asn Asp Ala Leu Lys Glu Leu Phe Pro Asp Asp Lys Asp Lys Arg Gln 
    770                 775                 780                 


Phe Phe Met Lys Cys Lys Phe Thr Asp Val Leu Ile Asn Asp Val Gly 
785                 790                 795                 800 


Glu Asn Asn Gln Ile Thr Glu Met Glu Asp Leu Glu Thr Ser Lys Glu 
                805                 810                 815     


Gln Gln Asn Arg Glu Ile Lys Arg Lys Asp Leu Leu Cys Phe Tyr Leu 
            820                 825                 830         


Phe Leu Arg Leu Leu Asp Glu Arg Glu Ile Ser Gly Leu Lys His Gln 
        835                 840                 845             


Phe Val Arg Tyr Arg Cys Ser Leu Lys Glu Arg Arg Leu Pro Asp Asn 
    850                 855                 860                 


Arg Lys Asp Val Asp Glu Glu Ile Val Leu Leu Glu Glu Leu Glu Glu 
865                 870                 875                 880 


Leu Met Glu Leu Val Ser Tyr Thr Met Pro Ser Val Pro Glu Leu Ser 
                885                 890                 895     


Gly Lys Ala Glu Ser Gly Leu Asp Leu Val Ile Ser Lys Tyr Phe Lys 
            900                 905                 910         


Asp Phe Phe Glu Lys Ser Ala Leu Lys Asn Gln Asp Ile Met Lys Leu 
        915                 920                 925             


Tyr Tyr Gln Ser Asp Asn Lys Thr Pro Val Phe Arg Lys Tyr Met Ala 
    930                 935                 940                 


Leu Leu Met Arg Ser Ala Pro Leu Gln Leu Tyr Lys Asp Met Phe Arg 
945                 950                 955                 960 


Asn Tyr Tyr Ile Ile Thr Glu Lys Glu Cys Gln Glu Tyr Ile Lys Thr 
                965                 970                 975     


Ser Gln Asp Ile Asp Ala Phe Gln Cys Lys Leu Asn Glu Leu His Lys 
            980                 985                 990         


Glu Leu Glu His Val Arg Leu Lys  Thr Val Glu Asp Lys  Lys Gly Lys 
        995                 1000                 1005             


Ile Phe  Tyr Tyr Leu Ala Gly  Ser Asp Ala Glu Arg  Val Lys Glu 
    1010                 1015                 1020             


Tyr Glu  Asp Thr Leu Ser Lys  Val Val Arg Tyr Lys  Arg Leu Gln 
    1025                 1030                 1035             


His Lys  Leu Thr Phe Glu Ser  Leu Tyr Thr Ile Phe  Lys Ile His 
    1040                 1045                 1050             


Val Asp  Ile Ala Ala Arg Met  Val Gly Tyr Thr Glu  Asp Trp Glu 
    1055                 1060                 1065             


Arg Asp  Met Leu Phe Leu Phe  Lys Ser Leu Glu Tyr  Asn Glu Lys 
    1070                 1075                 1080             


Leu Asn  Glu Gly Val Val Glu  Lys Ile Phe Asn Asn  Lys Asp Glu 
    1085                 1090                 1095             


Lys Gly  His Ile Val Lys Lys  Leu Lys Asp Asn Leu  Asn Ser Glu 
    1100                 1105                 1110             


Asp Lys  Glu Lys Ile Gly Ile  Leu Cys Trp His Lys  Glu Ile Thr 
    1115                 1120                 1125             


Asp Lys  Asn Phe Val Glu Ile  Ile Trp Ile Arg Asn  Pro Ile Ala 
    1130                 1135                 1140             


His Leu  Asn His Phe Met Gln  Thr Val Lys Asn Pro  Lys Arg Ser 
    1145                 1150                 1155             


Leu Glu  Lys Met Ile Asn Ala  Leu Cys Val Leu Leu  Ser Tyr Asp 
    1160                 1165                 1170             


Arg Lys  Arg Gln Asn Ser Val  Thr Lys Thr Ile Asn  Asp Leu Leu 
    1175                 1180                 1185             


Leu Asn  Glu Tyr His Val Lys  Ile Lys Trp Lys Arg  Trp Val Asp 
    1190                 1195                 1200             


Lys Asn  Cys Asn Ile Tyr Tyr  Tyr Ile Asp Glu Gln  Asn Ile Glu 
    1205                 1210                 1215             


Asn Glu  Pro Ile Leu His Ile  Lys His Leu His Met  Gly Glu Lys 
    1220                 1225                 1230             


Cys His  Val Asn Arg Asn Ala  Asp Met Phe Asp Arg  Gln Lys Glu 
    1235                 1240                 1245             


Trp Leu  Arg Asn Gly Ile Thr  Glu Glu Val Tyr Asp  Lys Ser Met 
    1250                 1255                 1260             


Leu Gly  Cys Ile Cys Arg Leu  Phe Lys Phe Asp Tyr  Asn Asp Leu 
    1265                 1270                 1275             


Tyr Gly  Ala Asn Arg Gln 
    1280                 


<210>  244
<211>  1225
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  244

Met Lys Ile Thr Lys Arg Lys Trp Gly Glu His His Pro Pro Leu Tyr 
1               5                   10                  15      


Phe Tyr Arg Asp Glu Asp Ser Gly Arg Leu Leu Ala Gln Asn Asp Arg 
            20                  25                  30          


Lys Gln Asp Tyr Thr Asp Thr Leu Phe Asn Asp Ile Ala Gln Asp Thr 
        35                  40                  45              


Phe Glu Arg Ser Leu Arg Asn Arg Leu Leu Lys Thr Pro Glu Lys Gly 
    50                  55                  60                  


Asp Lys Arg Phe Tyr Ser Asn Glu Ile Val Lys Leu Val Glu Lys Leu 
65                  70                  75                  80  


Cys Gln Gly Ala Asp Val Ala Glu Ile Met Lys Ser Met Glu Arg Ser 
                85                  90                  95      


Glu Lys Leu Arg Pro Lys Asn Glu Lys Glu Ile Lys Asn Leu Lys Lys 
            100                 105                 110         


Gln Leu Asp Gly Thr Leu Ser Glu Tyr Gly Lys Arg Tyr Thr Ala Pro 
        115                 120                 125             


Glu Gly Ala Met Thr Leu Asn Asp Ala Leu Phe Tyr Leu Val Glu Gly 
    130                 135                 140                 


Asn Pro Leu Lys Gln Ala Met Ala Lys Ala Glu Leu Gly Lys Ile Arg 
145                 150                 155                 160 


Glu Ala Leu Ile Lys Glu Lys Glu Asn Arg Ile Asn Arg Val Arg Tyr 
                165                 170                 175     


Ser Ile Lys Asn Asn Lys Ile Pro Leu Arg Ile Gln Gly Asp Gly Gly 
            180                 185                 190         


Ile Thr Pro Asn Asn Asp Arg Ala Ala Trp Leu Leu Gly Leu Met Lys 
        195                 200                 205             


Pro Ala Asp Pro Ala Lys Gly Ile Thr Asp Cys Tyr Pro Leu Leu Gly 
    210                 215                 220                 


Glu Leu Glu Glu Val Phe Asp Phe Asp Lys Leu Ser Lys Thr Leu His 
225                 230                 235                 240 


Glu Lys Ile Ser Arg Cys Gln Gly Arg Pro Arg Ser Ile Ala Met Ala 
                245                 250                 255     


Val Asp Glu Ala Leu Lys Gln Tyr Leu Arg Glu Leu Trp Glu Lys Ser 
            260                 265                 270         


Pro Ser Arg Gln Gln Asp Leu Lys Tyr Tyr Phe Gln Ala Val Gln Glu 
        275                 280                 285             


Tyr Phe Lys Asp Asn Phe Pro Ile Arg Thr Lys Arg Met Gly Ala Arg 
    290                 295                 300                 


Leu Arg Gln Glu Leu Leu Lys Asp Lys Thr Ser Leu Ser Arg Leu Leu 
305                 310                 315                 320 


Glu Pro Lys His Met Ala Asn Ala Val Arg Arg Arg Leu Ile Asn Gln 
                325                 330                 335     


Ser Thr Gln Met His Ile Leu Tyr Gly Lys Leu Tyr Ala Tyr Cys Cys 
            340                 345                 350         


Gly Glu Asp Gly Arg Leu Leu Val Asn Ser Glu Thr Leu Gln Arg Ile 
        355                 360                 365             


Gln Val His Glu Ala Val Lys Lys Gln Ala Met Thr Ala Val Leu Trp 
    370                 375                 380                 


Ser Ile Ser Arg Leu Arg Tyr Phe Tyr Gln Phe Glu Asp Gly Asp Ile 
385                 390                 395                 400 


Leu Ser Asn Lys Asn Pro Ile Lys Asp Phe Arg Asp Lys Phe Leu Arg 
                405                 410                 415     


Asp Thr Asn Lys Tyr Thr His Glu Asp Val Glu Ala Cys Lys Glu Lys 
            420                 425                 430         


Leu Gln Asp Phe Phe Pro Leu Lys Glu Leu Gln Glu Lys Ile Lys Glu 
        435                 440                 445             


Asp Ala Lys Gly Leu Gln Glu Thr Asp Asn Lys Gln Ala Asp Thr Thr 
    450                 455                 460                 


Asp Phe Lys Ala Ile Gly His Ile Val Arg Asp Asp Arg Lys Leu Cys 
465                 470                 475                 480 


Asn Gln Leu Leu Ala Glu Cys Val Ser Cys Ile Gly Glu Leu Arg His 
                485                 490                 495     


His Ile Phe His Tyr Lys Asn Val Thr Leu Ile Gln Ala Leu Lys Arg 
            500                 505                 510         


Ile Ala Asp Lys Val Lys Pro Glu Asp Leu Ser Val Leu Arg Ala Ile 
        515                 520                 525             


Tyr Leu Leu Asp Arg Arg Asn Leu Lys Lys Ala Phe Ala Lys Arg Ile 
    530                 535                 540                 


Ser Ser Met Asn Leu Pro Leu Tyr Tyr Arg Glu Asp Leu Leu Ser Arg 
545                 550                 555                 560 


Ile Phe Lys Lys Glu Gly Thr Ala Phe Phe Leu Tyr Ser Ala Lys Ile 
                565                 570                 575     


Gln Met Thr Pro Ser Phe Gln Arg Val Tyr Glu Arg Gly Lys Asn Leu 
            580                 585                 590         


Arg Arg Glu Phe Glu Cys Glu Arg Met Lys Ala Glu Ala Ser Asn Gly 
        595                 600                 605             


Gln Asn Gly Gln Asp Gly Asp Arg Leu Lys Trp Phe Arg Gln Leu Ala 
    610                 615                 620                 


Ala Gly Asp Ser Ala Asp Thr His Phe Asn Trp Ala Val Glu Ala Tyr 
625                 630                 635                 640 


Ala Glu Ser Ala Ala Asp Val Glu Asn Asn Val Glu Phe Asp Thr Asp 
                645                 650                 655     


Val Asp Ala Gln Arg Ala Leu Arg Asn Leu Leu Leu Leu Ile Tyr Arg 
            660                 665                 670         


His His Phe Leu Pro Glu Val Gln Lys Asp Glu Thr Leu Val Thr Gly 
        675                 680                 685             


Lys Ile His Lys Val Leu Glu Arg Asn Arg Gln Leu Ser Glu Gly Gln 
    690                 695                 700                 


Gly Pro Asn Gln Gly Lys Ala His Gly Tyr Ser Val Ile Glu Glu Leu 
705                 710                 715                 720 


Tyr His Glu Gly Met Pro Leu Ser Asp Leu Met Lys Gln Leu Gln Arg 
                725                 730                 735     


Arg Ile Ser Glu Thr Glu Arg Glu Ser Arg Glu Leu Ala Gln Glu Lys 
            740                 745                 750         


Thr Asp Tyr Ala Gln Arg Phe Ile Leu Asp Ile Phe Ala Glu Ala Phe 
        755                 760                 765             


Asn Asp Phe Leu Glu Ala His Tyr Gly Glu Glu Tyr Leu Glu Ile Met 
    770                 775                 780                 


Ser Pro Arg Lys Asp Ala Glu Ala Ala Lys Lys Trp Val Lys Glu Ser 
785                 790                 795                 800 


Lys Thr Val Asp Leu Lys Thr Ser Ile Asp Glu Lys Glu Pro Glu Gly 
                805                 810                 815     


His Leu Leu Val Leu Tyr Pro Val Leu Arg Leu Leu Asp Glu Arg Glu 
            820                 825                 830         


Leu Gly Glu Leu Gln Gln Gln Met Ile Arg Tyr Arg Thr Ser Leu Ala 
        835                 840                 845             


Ser Trp Gln Gly Glu Ser Asn Phe Ser Glu Glu Ile Arg Ile Ala Gly 
    850                 855                 860                 


Gln Ile Glu Glu Leu Thr Glu Leu Val Lys Leu Thr Glu Pro Glu Pro 
865                 870                 875                 880 


Gln Phe Ala Glu Glu Val Trp Gly Lys Arg Ala Lys Glu Ala Phe Glu 
                885                 890                 895     


Asp Phe Ile Glu Gly Asn Met Lys Asn Tyr Glu Ala Phe Tyr Leu Gln 
            900                 905                 910         


Ser Asp Asn Asn Thr Pro Val Tyr Arg Arg Asn Met Ser Arg Leu Leu 
        915                 920                 925             


Arg Ser Gly Leu Met Gly Val Tyr Gln Lys Val Leu Ala Ser His Lys 
    930                 935                 940                 


Gln Ala Leu Lys Arg Asp Tyr Leu Leu Trp Ser Glu Lys His Trp Asn 
945                 950                 955                 960 


Val Lys Asp Glu Asn Gly Ala Asp Ile Ser Ser Ala Glu Gln Ala Gln 
                965                 970                 975     


Cys Leu Leu Gln Arg Leu His Arg Lys Tyr Ala Glu Ser Pro Ser Arg 
            980                 985                 990         


Phe Thr Glu Glu Asp Cys Lys Leu  Tyr Glu Lys Val Leu  Arg Arg Leu 
        995                 1000                 1005             


Glu Asp  Tyr Asn Gln Ala Val  Lys Asn Leu Ser Phe  Ser Ser Leu 
    1010                 1015                 1020             


Tyr Glu  Ile Cys Val Leu Asn  Leu Glu Ile Leu Ser  Arg Trp Val 
    1025                 1030                 1035             


Gly Phe  Val Gln Asp Trp Glu  Arg Asp Met Tyr Phe  Leu Leu Leu 
    1040                 1045                 1050             


Ala Trp  Val Arg Gln Gly Lys  Leu Asp Gly Ile Lys  Glu Glu Asp 
    1055                 1060                 1065             


Val Arg  Asp Ile Phe Ser Glu  Gly Asn Ile Ile Arg  Asn Leu Val 
    1070                 1075                 1080             


Asp Thr  Leu Lys Gly Glu Asn  Met Asn Ala Phe Glu  Ser Val Tyr 
    1085                 1090                 1095             


Phe Pro  Glu Asn Lys Gly Ser  Lys Tyr Leu Gly Val  Arg Asn Asp 
    1100                 1105                 1110             


Val Ala  His Leu Asp Leu Met  Arg Lys Asn Gly Trp  Arg Leu Glu 
    1115                 1120                 1125             


Ala Gly  Lys Thr Cys Ser Val  Met Glu Asp Tyr Ile  Asn Arg Leu 
    1130                 1135                 1140             


Arg Phe  Leu Leu Ser Tyr Asp  Gln Lys Arg Met Asn  Ala Val Thr 
    1145                 1150                 1155             


Lys Thr  Leu Gln Gln Ile Phe  Asp Arg His Lys Val  Lys Ile Arg 
    1160                 1165                 1170             


Phe Thr  Val Glu Lys Gly Gly  Met Leu Lys Ile Glu  Asp Val Thr 
    1175                 1180                 1185             


Ala Asp  Lys Ile Ala His Leu  Lys Gly Ser Arg Leu  Ser Gly Ile 
    1190                 1195                 1200             


Glu Ile  Pro Ser His Gly Glu  Arg Phe Ile Asp Thr  Leu Lys Ala 
    1205                 1210                 1215             


Leu Met  Val Tyr Pro Arg Gly  
    1220                 1225 


<210>  245
<211>  1284
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  245

Met Ile Ile Gly Gly Ile Asn Met Lys Leu Thr Arg Arg Arg Ile Ser 
1               5                   10                  15      


Gln Glu Arg Lys Asn Gln Lys Leu Thr Ala Ala Phe Tyr Arg Asp Met 
            20                  25                  30          


Asp His Gly Leu Leu Tyr Val Asp Ser Glu Asp Glu Asp Arg Thr Glu 
        35                  40                  45              


Tyr Val Val Ser Ser Met Asp Phe Glu Arg Ser Trp Arg Gly Arg Ile 
    50                  55                  60                  


Leu Lys Asn Gly Glu Asp Asn Lys Asn Pro Phe Tyr Glu Phe Val Lys 
65                  70                  75                  80  


Gly Leu Val Gly Ser Asn Glu Ile Ile Cys Lys Pro Ile Thr Asn Asp 
                85                  90                  95      


Asn Asn Thr Asp Ile Asn Glu Lys Ile Lys Lys Tyr Ile Thr Glu Phe 
            100                 105                 110         


Gly Arg Asn Leu Lys Ala Pro Gly Ser Glu Val Thr Leu Glu Lys Leu 
        115                 120                 125             


Ile Leu Asn Ile Gln Ser Gly Thr Ser Glu Asn Glu Val Arg Pro Glu 
    130                 135                 140                 


Leu Glu Lys Ile Lys Asp Met Ile Lys Lys Asp Ile Glu Lys Arg Lys 
145                 150                 155                 160 


Asp Glu Leu Ile Lys Ser Ile Thr Asn Asn His Ile Pro Phe Met Leu 
                165                 170                 175     


Asp Glu Asp Lys Leu Val Pro Ser Thr Lys Lys Met Lys Trp Leu Tyr 
            180                 185                 190         


Lys Phe Leu Asn Gly Pro Asp Lys Ser Leu Asn Leu Gln Met Phe Asp 
        195                 200                 205             


Glu Tyr Trp Thr Lys Tyr Gly Tyr Lys Asn Leu Glu Glu Lys Ile Ile 
    210                 215                 220                 


Lys Glu Ile Asn Ser Leu Pro Glu Lys Asn Ala Arg Ser Ile Ser Arg 
225                 230                 235                 240 


Ala Val Ser Lys Thr Val Arg Glu Tyr Asn Arg Asn Phe Arg Ile Asn 
                245                 250                 255     


Tyr Met Val Pro Glu Asn Glu Asn Ala Glu Ala Asp Ser Asp Tyr Glu 
            260                 265                 270         


Gly Phe Leu Leu Phe Leu Lys Ala Val Glu Gln His Phe Lys Lys Tyr 
        275                 280                 285             


Tyr Pro Val Lys Ser Lys Asp Ser Asn Glu Val Arg Asp Lys Asn Leu 
    290                 295                 300                 


Cys Glu Glu Lys Asn Tyr Lys Phe Tyr Cys Ser Tyr Asn Phe Val Lys 
305                 310                 315                 320 


Asn Glu Val Lys Arg Ser Ile Ile Asn Gln Leu Val Ser Gly Leu Ile 
                325                 330                 335     


Gln Gln Gly Lys Leu Leu His Tyr Phe Tyr Lys Asp Gly Ile Trp Gln 
            340                 345                 350         


Gln Asp Phe Leu Asn Ser Tyr Gly Leu Ser Tyr Ile Gln Val Glu Glu 
        355                 360                 365             


Ser Phe Lys Lys Ser Leu Met Thr Ser Leu Ser Trp Gly Ile Asn Arg 
    370                 375                 380                 


Leu Thr Ser Phe Phe Ile Asp Val Gly Thr Asp Glu Asn Glu Glu Lys 
385                 390                 395                 400 


Thr Val Gln Asn Lys Lys Gln Lys Asn Asn Arg Lys Ile Asp Asp Ile 
                405                 410                 415     


Leu Ser Asp Lys Ser Asn Leu Arg Ala Ile Phe Asn Asp Leu Arg Ser 
            420                 425                 430         


Asn Thr Glu Leu Gln Lys His Phe Lys Glu Lys Leu Ala Phe Cys Tyr 
        435                 440                 445             


Pro Ile Phe Ile Lys Val Lys Lys Glu Lys Met Phe Asp Asp Ile Glu 
    450                 455                 460                 


Lys Leu Ile Lys Leu Val Glu Glu Ala Arg Glu Ser Val Ala Tyr Leu 
465                 470                 475                 480 


Arg His Arg Cys Phe His Tyr Lys Asp Val Thr Ile Thr Glu Met Leu 
                485                 490                 495     


Lys Ala Leu Asn Asn Asn Thr Glu Thr Asp Lys Thr Glu Asp Ile Asp 
            500                 505                 510         


Tyr Ser Val Ala Ala Glu Tyr Phe Leu Arg Asp Ile Asn Asn Leu Tyr 
        515                 520                 525             


Asp Ala Phe Arg Glu Gln Ile Arg Ser Ser Gly Ile Ala Asp Tyr Tyr 
    530                 535                 540                 


Pro Ala Asp Ile Ile Ser Gly Cys Phe Lys Lys Cys Gly Leu Gln Phe 
545                 550                 555                 560 


Val Leu Tyr Ser Pro Gln Asn Ser Leu Met Pro Ser Phe Lys Asn Ile 
                565                 570                 575     


Tyr Lys Arg Gly Ser Asn Leu Tyr Lys Ala Tyr Gln Glu Glu Lys Glu 
            580                 585                 590         


Gln Lys Asp Lys Glu Tyr Lys Arg His Asn Thr Asn Ile Val Gln Glu 
        595                 600                 605             


Glu Ser Lys Glu Leu Ser Trp Tyr Ile Glu Val Ser Asp Thr Glu Gln 
    610                 615                 620                 


Gly Lys Thr Ala Tyr Arg Asn Leu Leu Gln Leu Ile Tyr Tyr His Ala 
625                 630                 635                 640 


Phe Leu Pro Glu Val Arg Glu Asn Glu Ser Leu Ile Thr Val Tyr Phe 
                645                 650                 655     


Ala Lys Thr Lys Glu Trp Asn Arg Lys Val Ala Glu Thr Lys Ala Lys 
            660                 665                 670         


Lys Lys Asn Ala Gly Lys Thr Tyr Lys Asp Lys Pro Ile Arg Ala Tyr 
        675                 680                 685             


Arg Tyr Glu Ala Ile Pro Asp Tyr Val Gly Glu Arg Leu Asp Asp Tyr 
    690                 695                 700                 


Phe Lys Ile Leu Gln Arg Glu Gln Met Ala Lys Ala Lys Asp Val Asn 
705                 710                 715                 720 


Glu Gly Asn Ala Glu Asn Asn Asn Tyr Ile Gln Phe Ile Arg Asp Val 
                725                 730                 735     


Val Val Trp Ala Phe Gly Ala Tyr Leu Glu Glu Arg Leu Glu Lys Tyr 
            740                 745                 750         


Lys Lys Asp Leu Gln Ser Ser His Ser Gln Lys Asp Lys Lys Asp Val 
        755                 760                 765             


Asn Asp Ala Leu Lys Glu Leu Phe Pro Asp Asp Lys Asp Lys Arg Gln 
    770                 775                 780                 


Phe Phe Met Lys Cys Lys Phe Thr Asp Val Leu Ile Asn Asp Val Gly 
785                 790                 795                 800 


Glu Asn Asn Gln Ile Thr Glu Met Glu Asp Leu Glu Thr Ser Lys Glu 
                805                 810                 815     


Gln Gln Asn Arg Glu Ile Lys Arg Lys Asp Leu Leu Cys Phe Tyr Leu 
            820                 825                 830         


Phe Leu Arg Leu Leu Asp Glu Arg Glu Ile Ser Gly Leu Lys His Gln 
        835                 840                 845             


Phe Val Arg Tyr Arg Cys Ser Leu Lys Glu Arg Arg Leu Pro Asp Asn 
    850                 855                 860                 


Arg Lys Asp Val Asp Glu Glu Ile Val Leu Leu Glu Glu Leu Glu Glu 
865                 870                 875                 880 


Leu Met Glu Leu Val Ser Tyr Thr Met Pro Ser Val Pro Glu Leu Ser 
                885                 890                 895     


Gly Lys Ala Glu Ser Gly Leu Asp Leu Val Ile Ser Lys Tyr Phe Lys 
            900                 905                 910         


Asp Phe Phe Glu Lys Ser Ala Leu Lys Asn Gln Asp Ile Met Lys Leu 
        915                 920                 925             


Tyr Tyr Gln Ser Asp Asn Lys Thr Pro Val Phe Arg Lys Tyr Met Ala 
    930                 935                 940                 


Leu Leu Met Arg Ser Ala Pro Leu Gln Leu Tyr Lys Asp Met Phe Arg 
945                 950                 955                 960 


Asn Tyr Tyr Ile Ile Thr Glu Lys Glu Cys Gln Glu Tyr Ile Lys Thr 
                965                 970                 975     


Ser Gln Asp Ile Asp Ala Phe Gln Cys Lys Leu Asn Glu Leu His Lys 
            980                 985                 990         


Glu Leu Glu His Val Arg Leu Lys  Thr Val Glu Asp Lys  Lys Gly Lys 
        995                 1000                 1005             


Ile Phe  Tyr Tyr Leu Ala Gly  Ser Asp Ala Glu Arg  Val Lys Glu 
    1010                 1015                 1020             


Tyr Glu  Asp Thr Leu Ser Lys  Val Val Arg Tyr Lys  Arg Leu Gln 
    1025                 1030                 1035             


His Lys  Leu Thr Phe Glu Ser  Leu Tyr Thr Ile Phe  Lys Ile His 
    1040                 1045                 1050             


Val Asp  Ile Ala Ala Arg Met  Val Gly Tyr Thr Glu  Asp Trp Glu 
    1055                 1060                 1065             


Arg Asp  Met Leu Phe Leu Phe  Lys Ser Leu Glu Tyr  Asn Glu Lys 
    1070                 1075                 1080             


Leu Asn  Glu Gly Val Val Glu  Lys Ile Phe Asn Asn  Lys Asp Glu 
    1085                 1090                 1095             


Lys Gly  His Ile Val Lys Lys  Leu Lys Asp Asn Leu  Asn Ser Glu 
    1100                 1105                 1110             


Asp Lys  Glu Lys Ile Gly Ile  Leu Cys Trp His Lys  Glu Ile Thr 
    1115                 1120                 1125             


Asp Lys  Asn Phe Val Glu Ile  Ile Trp Ile Arg Asn  Pro Ile Ala 
    1130                 1135                 1140             


His Leu  Asn His Phe Met Gln  Thr Val Lys Asn Pro  Lys Arg Ser 
    1145                 1150                 1155             


Leu Glu  Lys Met Ile Asn Ala  Leu Cys Val Leu Leu  Ser Tyr Asp 
    1160                 1165                 1170             


Arg Lys  Arg Gln Asn Ser Val  Thr Lys Thr Ile Asn  Asp Leu Leu 
    1175                 1180                 1185             


Leu Asn  Glu Tyr His Val Lys  Ile Lys Trp Lys Arg  Trp Val Asp 
    1190                 1195                 1200             


Lys Asn  Cys Asn Ile Tyr Tyr  Tyr Ile Asp Glu Gln  Asn Ile Glu 
    1205                 1210                 1215             


Asn Glu  Pro Ile Leu His Ile  Lys His Leu His Met  Gly Glu Lys 
    1220                 1225                 1230             


Cys His  Val Asn Arg Asn Ala  Asp Met Phe Asp Arg  Gln Lys Glu 
    1235                 1240                 1245             


Trp Leu  Arg Asn Gly Ile Thr  Glu Glu Val Tyr Asp  Lys Ser Met 
    1250                 1255                 1260             


Leu Gly  Cys Ile Cys Arg Leu  Phe Lys Phe Asp Tyr  Asn Asp Leu 
    1265                 1270                 1275             


Tyr Gly  Ala Asn Arg Gln 
    1280                 


<210>  246
<211>  1225
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  246

Met Lys Ile Thr Lys Arg Lys Trp Gly Glu His His Pro Pro Leu Tyr 
1               5                   10                  15      


Phe Tyr Arg Asp Glu Asp Ser Gly Arg Leu Leu Ala Gln Asn Asp Arg 
            20                  25                  30          


Lys Gln Asp Tyr Thr Asp Thr Leu Phe Asn Asp Ile Ala Gln Asp Thr 
        35                  40                  45              


Phe Glu Arg Ser Leu Arg Asn Arg Leu Leu Lys Thr Pro Glu Lys Gly 
    50                  55                  60                  


Asp Lys Arg Phe Tyr Ser Asn Glu Ile Val Lys Leu Val Glu Lys Leu 
65                  70                  75                  80  


Cys Gln Gly Ala Asp Val Ala Glu Ile Met Lys Ser Met Glu Arg Ser 
                85                  90                  95      


Glu Lys Leu Arg Pro Lys Asn Glu Lys Glu Ile Lys Asn Leu Lys Lys 
            100                 105                 110         


Gln Leu Asp Gly Thr Leu Ser Glu Tyr Gly Lys Arg Tyr Thr Ala Pro 
        115                 120                 125             


Glu Gly Ala Met Thr Leu Asn Asp Ala Leu Phe Tyr Leu Val Glu Gly 
    130                 135                 140                 


Asn Pro Leu Lys Gln Ala Met Ala Lys Ala Glu Leu Gly Lys Ile Arg 
145                 150                 155                 160 


Glu Ala Leu Ile Lys Glu Lys Glu Asn Arg Ile Asn Arg Val Arg Tyr 
                165                 170                 175     


Ser Ile Lys Asn Asn Lys Ile Pro Leu Arg Ile Gln Gly Asp Gly Gly 
            180                 185                 190         


Ile Thr Pro Asn Asn Asp Arg Ala Ala Trp Leu Leu Gly Leu Met Lys 
        195                 200                 205             


Pro Ala Asp Pro Ala Lys Gly Ile Thr Asp Cys Tyr Pro Leu Leu Gly 
    210                 215                 220                 


Glu Leu Glu Glu Val Phe Asp Phe Asp Lys Leu Ser Lys Thr Leu His 
225                 230                 235                 240 


Glu Lys Ile Ser Arg Cys Gln Gly Arg Pro Arg Ser Ile Ala Met Ala 
                245                 250                 255     


Val Asp Glu Ala Leu Lys Gln Tyr Leu Arg Glu Leu Trp Glu Lys Ser 
            260                 265                 270         


Pro Ser Arg Gln Gln Asp Leu Lys Tyr Tyr Phe Gln Ala Val Gln Glu 
        275                 280                 285             


Tyr Phe Lys Asp Asn Phe Pro Ile Arg Thr Lys Arg Met Gly Ala Arg 
    290                 295                 300                 


Leu Arg Gln Glu Leu Leu Lys Asp Lys Thr Ser Leu Ser Arg Leu Leu 
305                 310                 315                 320 


Glu Pro Lys His Met Ala Asn Ala Val Arg Arg Arg Leu Ile Asn Gln 
                325                 330                 335     


Ser Thr Gln Met His Ile Leu Tyr Gly Lys Leu Tyr Ala Tyr Cys Cys 
            340                 345                 350         


Gly Glu Asp Gly Arg Leu Leu Val Asn Ser Glu Thr Leu Gln Arg Ile 
        355                 360                 365             


Gln Val His Glu Ala Val Lys Lys Gln Ala Met Thr Ala Val Leu Trp 
    370                 375                 380                 


Ser Ile Ser Arg Leu Arg Tyr Phe Tyr Gln Phe Glu Asp Gly Asp Ile 
385                 390                 395                 400 


Leu Ser Asn Lys Asn Pro Ile Lys Asp Phe Arg Asp Lys Phe Leu Arg 
                405                 410                 415     


Asp Thr Asn Lys Tyr Thr His Glu Asp Val Glu Ala Cys Lys Glu Lys 
            420                 425                 430         


Leu Gln Asp Phe Phe Pro Leu Lys Glu Leu Gln Glu Lys Ile Lys Glu 
        435                 440                 445             


Asp Ala Lys Gly Leu Gln Glu Thr Asp Asn Lys Gln Ala Asp Thr Thr 
    450                 455                 460                 


Asp Phe Lys Ala Ile Gly His Ile Val Arg Asp Asp Arg Lys Leu Cys 
465                 470                 475                 480 


Asn Gln Leu Leu Ala Glu Cys Val Ser Cys Ile Gly Glu Leu Arg His 
                485                 490                 495     


His Ile Phe His Tyr Lys Asn Val Thr Leu Ile Gln Ala Leu Lys Arg 
            500                 505                 510         


Ile Ala Asp Lys Val Lys Pro Glu Asp Leu Ser Val Leu Arg Ala Ile 
        515                 520                 525             


Tyr Leu Leu Asp Arg Arg Asn Leu Lys Lys Ala Phe Ala Lys Arg Ile 
    530                 535                 540                 


Ser Ser Met Asn Leu Pro Leu Tyr Tyr Arg Glu Asp Leu Leu Ser Arg 
545                 550                 555                 560 


Ile Phe Lys Lys Glu Gly Thr Ala Phe Phe Leu Tyr Ser Ala Lys Ile 
                565                 570                 575     


Gln Met Thr Pro Ser Phe Gln Arg Val Tyr Glu Arg Gly Lys Asn Leu 
            580                 585                 590         


Arg Arg Glu Phe Glu Cys Glu Arg Met Lys Ala Glu Ala Ser Asn Gly 
        595                 600                 605             


Gln Asn Gly Gln Asp Gly Asp Arg Leu Lys Trp Phe Arg Gln Leu Ala 
    610                 615                 620                 


Ala Gly Asp Ser Ala Asp Thr His Phe Asn Trp Ala Val Glu Ala Tyr 
625                 630                 635                 640 


Ala Glu Ser Ala Ala Asp Val Glu Asn Asn Val Glu Phe Asp Thr Asp 
                645                 650                 655     


Val Asp Ala Gln Arg Ala Leu Arg Asn Leu Leu Leu Leu Ile Tyr Arg 
            660                 665                 670         


His His Phe Leu Pro Glu Val Gln Lys Asp Glu Thr Leu Val Thr Gly 
        675                 680                 685             


Lys Ile His Lys Val Leu Glu Arg Asn Arg Gln Leu Ser Glu Gly Gln 
    690                 695                 700                 


Gly Pro Asn Gln Gly Lys Ala His Gly Tyr Ser Val Ile Glu Glu Leu 
705                 710                 715                 720 


Tyr His Glu Gly Met Pro Leu Ser Asp Leu Met Lys Gln Leu Gln Arg 
                725                 730                 735     


Arg Ile Ser Glu Thr Glu Arg Glu Ser Arg Glu Leu Ala Gln Glu Lys 
            740                 745                 750         


Thr Asp Tyr Ala Gln Arg Phe Ile Leu Asp Ile Phe Ala Glu Ala Phe 
        755                 760                 765             


Asn Asp Phe Leu Glu Ala His Tyr Gly Glu Glu Tyr Leu Glu Ile Met 
    770                 775                 780                 


Ser Pro Arg Lys Asp Ala Glu Ala Ala Lys Lys Trp Val Lys Glu Ser 
785                 790                 795                 800 


Lys Thr Val Asp Leu Lys Thr Ser Ile Asp Glu Lys Glu Pro Glu Gly 
                805                 810                 815     


His Leu Leu Val Leu Tyr Pro Val Leu Arg Leu Leu Asp Glu Arg Glu 
            820                 825                 830         


Leu Gly Glu Leu Gln Gln Gln Met Ile Arg Tyr Arg Thr Ser Leu Ala 
        835                 840                 845             


Ser Trp Gln Gly Glu Ser Asn Phe Ser Glu Glu Ile Arg Ile Ala Gly 
    850                 855                 860                 


Gln Ile Glu Glu Leu Thr Glu Leu Val Lys Leu Thr Glu Pro Glu Pro 
865                 870                 875                 880 


Gln Phe Ala Glu Glu Val Trp Gly Lys Arg Ala Lys Glu Ala Phe Glu 
                885                 890                 895     


Asp Phe Ile Glu Gly Asn Met Lys Asn Tyr Glu Ala Phe Tyr Leu Gln 
            900                 905                 910         


Ser Asp Asn Asn Thr Pro Val Tyr Arg Arg Asn Met Ser Arg Leu Leu 
        915                 920                 925             


Arg Ser Gly Leu Met Gly Val Tyr Gln Lys Val Leu Ala Ser His Lys 
    930                 935                 940                 


Gln Ala Leu Lys Arg Asp Tyr Leu Leu Trp Ser Glu Lys His Trp Asn 
945                 950                 955                 960 


Val Lys Asp Glu Asn Gly Ala Asp Ile Ser Ser Ala Glu Gln Ala Gln 
                965                 970                 975     


Cys Leu Leu Gln Arg Leu His Arg Lys Tyr Ala Glu Ser Pro Ser Arg 
            980                 985                 990         


Phe Thr Glu Glu Asp Cys Lys Leu  Tyr Glu Lys Val Leu  Arg Arg Leu 
        995                 1000                 1005             


Glu Asp  Tyr Asn Gln Ala Val  Lys Asn Leu Ser Phe  Ser Ser Leu 
    1010                 1015                 1020             


Tyr Glu  Ile Cys Val Leu Asn  Leu Glu Ile Leu Ser  Arg Trp Val 
    1025                 1030                 1035             


Gly Phe  Val Gln Asp Trp Glu  Arg Asp Met Tyr Phe  Leu Leu Leu 
    1040                 1045                 1050             


Ala Trp  Val Arg Gln Gly Lys  Leu Asp Gly Ile Lys  Glu Glu Asp 
    1055                 1060                 1065             


Val Arg  Asp Ile Phe Ser Glu  Gly Asn Ile Ile Arg  Asn Leu Val 
    1070                 1075                 1080             


Asp Thr  Leu Lys Gly Glu Asn  Met Asn Ala Phe Glu  Ser Val Tyr 
    1085                 1090                 1095             


Phe Pro  Glu Asn Lys Gly Ser  Lys Tyr Leu Gly Val  Arg Asn Asp 
    1100                 1105                 1110             


Val Ala  His Leu Asp Leu Met  Arg Lys Asn Gly Trp  Arg Leu Glu 
    1115                 1120                 1125             


Ala Gly  Lys Thr Cys Ser Val  Met Glu Asp Tyr Ile  Asn Arg Leu 
    1130                 1135                 1140             


Arg Phe  Leu Leu Ser Tyr Asp  Gln Lys Arg Met Asn  Ala Val Thr 
    1145                 1150                 1155             


Lys Thr  Leu Gln Gln Ile Phe  Asp Arg His Lys Val  Lys Ile Arg 
    1160                 1165                 1170             


Phe Thr  Val Glu Lys Gly Gly  Met Leu Lys Ile Glu  Asp Val Thr 
    1175                 1180                 1185             


Ala Asp  Lys Ile Ala His Leu  Lys Gly Ser Arg Leu  Ser Gly Ile 
    1190                 1195                 1200             


Glu Ile  Pro Ser His Gly Glu  Arg Phe Ile Asp Thr  Leu Lys Ala 
    1205                 1210                 1215             


Leu Met  Val Tyr Pro Arg Gly  
    1220                 1225 


<210>  247
<211>  1194
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  247

Met Lys Val Thr Lys Ile Asp Gly Leu Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ile Glu Asp Ala Ser Gln Lys Asn Glu Thr 
            20                  25                  30          


Leu Glu Arg Leu Glu Asn Leu Lys Gly Ile Lys Leu Gly Asn Tyr Ile 
        35                  40                  45              


Lys Asn Thr Asp Lys Thr Lys Asn Lys Asp Asn Lys Lys Arg Arg Lys 
    50                  55                  60                  


Gly Leu Lys Glu Tyr Phe Ser Glu Ile Thr Leu Arg Lys Glu Asn Glu 
65                  70                  75                  80  


Lys Tyr Val Leu Leu Lys Gly Lys Lys Leu Lys Lys Ile Asn Asn Asp 
                85                  90                  95      


Ile Lys Asp Thr Asp Ile Lys Ala Lys Asp Lys Lys Glu Glu Val Phe 
            100                 105                 110         


Asp Ile Leu Lys Glu Ile Leu Lys Leu Asn Leu Leu Ala Asn Asp Ala 
        115                 120                 125             


Glu Glu Lys Ile Gln Phe Asp Ser Ile Lys Leu Lys Asn Val Phe Gly 
    130                 135                 140                 


Lys Asp Phe Val Lys Lys Glu Leu Gln Ile Lys Ser Ile Glu Glu Ser 
145                 150                 155                 160 


Leu Glu Lys Asn Lys Ala Asp Tyr Arg Lys Glu Phe Ile Glu Thr Glu 
                165                 170                 175     


Asn His Lys Tyr Gly Asn Val Lys Gly Lys Asn Lys Arg Ser His Ile 
            180                 185                 190         


Tyr Glu Tyr Tyr Lys Lys Ser Glu Asn His Lys Lys Phe Glu Asp Asn 
        195                 200                 205             


Ile Arg Glu Ala Phe Glu Lys Leu Tyr Thr Glu Glu Asn Ile Lys Glu 
    210                 215                 220                 


Leu Tyr Ser Lys Ile Glu Gln Val Leu Lys Lys Thr His Leu Lys Ser 
225                 230                 235                 240 


Ile Val Trp Glu Phe Tyr Lys Asn Glu Ile Ile Gly Glu Ser Glu Phe 
                245                 250                 255     


Ser Lys Lys Asn Gly Asp Gly Ile Ser Ile Leu Tyr Asn Gln Ile Lys 
            260                 265                 270         


Asp Ser Ile Lys Lys Glu Glu Asn Phe Ile Glu Phe Ile Glu Asn Ile 
        275                 280                 285             


Gly Asn Leu Glu Leu Lys Asp Leu Thr Lys Ser Gln Ile Phe Tyr Lys 
    290                 295                 300                 


Tyr Phe Leu Glu Asn Glu Glu Leu Asn Asp Glu Asn Ile Lys Phe Val 
305                 310                 315                 320 


Phe Cys Tyr Phe Val Glu Ile Glu Val Ser Asp Leu Leu Lys Gly Asn 
                325                 330                 335     


Val Tyr Lys Ala Ser Lys Ile Tyr Glu Asn Lys Ile Lys Asn Ile Phe 
            340                 345                 350         


Glu Tyr Gly Lys Leu Lys Lys Leu Ile Val Tyr Lys Leu Glu Asn Lys 
        355                 360                 365             


Leu Asn Asn Tyr Val Arg Asn Cys Gly Lys Tyr Asn Tyr His Met Glu 
    370                 375                 380                 


Asn Gly Asp Ile Ala Thr Ser Asp Ile Asn Met Arg Asn Arg Gln Thr 
385                 390                 395                 400 


Glu Ala Phe Leu Arg Ser Met Ile Gly Val Ser Ser Phe Gly Tyr Phe 
                405                 410                 415     


Ser Leu Arg Asn Ile Leu Gly Val Asn Asp Asp Asp Phe Tyr Glu Ile 
            420                 425                 430         


Glu Glu Asp Leu Thr Glu Glu Glu Arg Lys Asn Glu Ser Asn Ala Leu 
        435                 440                 445             


Lys Lys Ala Lys Glu Asp Ile Thr Ser Lys Ser Ile Phe Glu Lys Val 
    450                 455                 460                 


Val Asp Lys Ser Phe Glu Lys Lys Gly Ile Tyr Ser Ile Lys Glu Asn 
465                 470                 475                 480 


Leu Lys Met Phe Tyr Gly Asp Ser Phe Asp Lys Ala Asn Glu Asp Glu 
                485                 490                 495     


Leu Lys Gln Phe Phe Val Asn Met Leu Asn Ala Ile Thr Ser Ile Arg 
            500                 505                 510         


His Arg Val Val His Tyr Asn Met Asn Thr Asn Ser Glu Asn Ile Phe 
        515                 520                 525             


Asn Phe Ser Asp Ile Glu Val Ser Arg Leu Leu Lys Asn Ile Phe Glu 
    530                 535                 540                 


Lys Glu Thr Asp Lys Arg Glu Leu Lys Leu Lys Ile Phe Arg Gln Leu 
545                 550                 555                 560 


Asn Ser Ala Gly Val Phe Asp Tyr Trp Glu Ser Trp Lys Ile Lys Lys 
                565                 570                 575     


Tyr Leu Glu Asn Ile Glu Phe Lys Phe Val Asn Lys Asn Ile Pro Phe 
            580                 585                 590         


Val Pro Ser Phe Thr Lys Leu Tyr Asn Arg Ile Asp Asn Leu Lys Gly 
        595                 600                 605             


Asn Asn Ala Leu Lys Leu Gly Asn Tyr Ile Thr Ile Pro Lys Arg Lys 
    610                 615                 620                 


Glu Ala Arg Asp Ser Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly 
625                 630                 635                 640 


Glu Phe Val Glu Lys Phe Val Asn Asn Asn Asp Asn Phe Glu Lys Ile 
                645                 650                 655     


Phe Arg Glu Ile Ile Glu Ile Asn Lys Asn Ala Gly Thr Asn Thr Lys 
            660                 665                 670         


Thr Lys Phe Tyr Lys Leu Glu Lys Phe Glu Thr Leu Lys Ala Asn Thr 
        675                 680                 685             


Pro Thr Glu Tyr Leu Glu Lys Leu Gln Ser Leu His Gln Ile Asn Tyr 
    690                 695                 700                 


Asp Arg Glu Lys Ile Glu Glu Ala Lys Asp Ile Tyr Val Asp Phe Val 
705                 710                 715                 720 


Gln Lys Ile Phe Leu Lys Gly Phe Ile Asn Tyr Leu Gln Lys Ser Asn 
                725                 730                 735     


Ser Leu Lys Pro Leu Asn Leu Leu Asn Leu Lys Lys Asp Glu Val Ile 
            740                 745                 750         


Asn Ser Glu Lys Ser Ser Tyr Asp Glu Lys Leu Lys Gln Trp Glu Asn 
        755                 760                 765             


Asn Gly Ser Lys Leu Ser Glu Met Pro Lys Glu Ile Tyr Lys Tyr Ile 
    770                 775                 780                 


Lys Glu Ile Asn Ile Asn Lys Ile Asn Tyr Ser Asn Arg Met Ser Ile 
785                 790                 795                 800 


Phe Tyr Leu Leu Leu Lys Leu Ile Asp His Arg Glu Leu Thr Asn Leu 
                805                 810                 815     


Arg Gly Asn Leu Glu Lys Tyr Glu Ser Met Asn Lys Asn Lys Ile Tyr 
            820                 825                 830         


Ser Glu Glu Leu Asn Ile Val Asn Leu Val Ser Leu Asp Asn Asn Lys 
        835                 840                 845             


Val Arg Thr Asn Phe Ser Val Glu Ala Glu Asp Ile Gly Lys Phe Leu 
    850                 855                 860                 


Lys Thr Glu Thr Ser Ile Lys Asn Asn Lys Gln Leu Asn Asn Phe Ser 
865                 870                 875                 880 


Glu Ile Phe Ala Asp Gly Glu Asn Val Ile Lys His Arg Ser Phe Tyr 
                885                 890                 895     


Asn Ile Lys Lys Tyr Gly Ile Leu Asp Leu Leu Glu Lys Ile Val Thr 
            900                 905                 910         


Lys Ala Asp Leu Lys Ile Thr Lys Glu Glu Ile Lys Lys Tyr Lys Asn 
        915                 920                 925             


Leu Gln Lys Glu Leu Glu Lys Asn Asp Phe Tyr Lys Ile Gln Glu Asn 
    930                 935                 940                 


Ile His Arg Lys Tyr Asn Gln Lys Pro Asn Leu Ile Ser Arg Thr Glu 
945                 950                 955                 960 


Asn Lys Lys Asp Phe Asn Asp Tyr Lys Lys Ala Ile Glu Asn Ile Gln 
                965                 970                 975     


Asn Tyr Thr Gln Leu Lys Asn Lys Ile Glu Phe Asn Asp Leu Asn Leu 
            980                 985                 990         


Leu Gln Ser Leu Leu Phe Arg Ile  Leu His Arg Leu Ala  Gly Tyr Thr 
        995                 1000                 1005             


Ser Leu  Trp Glu Arg Asp Leu  Gln Phe Lys Leu Lys  Gly Glu Phe 
    1010                 1015                 1020             


Pro Glu  Asp Lys Tyr Ile Asp  Glu Ile Phe Asn Ser  Asp Arg Asn 
    1025                 1030                 1035             


Asn Asn  Gln Lys Tyr Lys Ser  Gly Gly Ile Ala Tyr  Lys Tyr Val 
    1040                 1045                 1050             


Asp Phe  Leu Ile Glu Lys Glu  Glu Gly Lys Arg Ala  Gly Lys Asn 
    1055                 1060                 1065             


Lys Val  Lys Lys Arg Ser Glu  Lys Glu Gly Ser Phe  Ile Ile Arg 
    1070                 1075                 1080             


Asn Tyr  Ile Ala His Phe Asn  Tyr Ile Pro Asp Ala  Glu Lys Ser 
    1085                 1090                 1095             


Ile Leu  Glu Ile Leu Glu Glu  Leu Arg Glu Leu Leu  Lys Tyr Asp 
    1100                 1105                 1110             


Arg Lys  Leu Lys Asn Ala Val  Met Lys Ser Val Lys  Asp Ile Phe 
    1115                 1120                 1125             


Lys Glu  Tyr Gly Phe Ile Val  Glu Phe Gly Ile Ser  His Glu Ser 
    1130                 1135                 1140             


Asn Asn  Lys Lys Ile Thr Ile  Asn Lys Val Tyr Ser  Glu Lys Ile 
    1145                 1150                 1155             


Glu His  Leu Lys Lys Ala Lys  Leu Glu Lys Glu Asp  Lys Leu Glu 
    1160                 1165                 1170             


Thr Thr  Arg Asn Ser Glu Asp  Leu Cys Lys Leu Val  Lys Val Met 
    1175                 1180                 1185             


Leu Glu  Tyr Lys Lys Ser 
    1190                 


<210>  248
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  248

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Ile Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Phe Asp Phe Lys Leu  Leu Asn 
    1400                 1405                 1410         


<210>  249
<211>  1330
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  249

Met Lys Arg Glu Lys Asn Ile Thr Ile Met Lys Ile Ser Lys Val Asn 
1               5                   10                  15      


His Arg Arg Met Ala Val Ala Leu Asn Gly Asp Lys Ser Glu Leu Gly 
            20                  25                  30          


Gly Ile Leu Tyr Glu Ala Pro Val Gln Lys Asp Lys Asn Gly Asn Tyr 
        35                  40                  45              


Asn Asp Val Ile Ala Glu Thr Gly Lys Val Val Asn Glu Ala Leu Asp 
    50                  55                  60                  


Lys Lys Ser Arg Leu Tyr Thr Pro Phe Asn Asn Gln Lys Val Ile Ile 
65                  70                  75                  80  


Asp Lys Asn Leu Gln Arg Tyr Ala Asn Asn Leu Lys Arg Cys Tyr Ile 
                85                  90                  95      


Asn Phe Val Lys Gln Tyr Val Asn Asn Lys Ser Phe Asn Tyr Lys Ala 
            100                 105                 110         


Met Gln Phe Ile Pro Asp Ile Gln Asn Pro Lys Thr Asn Asp Ala Val 
        115                 120                 125             


Asn Tyr Arg Thr Asp Arg Asp Asn Val Tyr Asn Lys Asn Lys Tyr Tyr 
    130                 135                 140                 


Asp Lys Gln Thr Lys Ser Lys Ser Lys Lys Phe Ile Tyr Glu Lys Ile 
145                 150                 155                 160 


Val Ile Pro Gln Asn Glu Gln Asn Ile Val Ile Ser Ala Leu Val Asn 
                165                 170                 175     


Cys Ser Leu Arg Lys Ser Leu Arg Lys Asp Val Ser Tyr Lys Thr Lys 
            180                 185                 190         


Ser Gly Glu Ile Lys Thr Tyr Asn Leu Pro Glu Leu Val Lys Lys Ser 
        195                 200                 205             


Met Arg Phe Tyr Cys Leu Glu Gly Gln Arg Glu Pro Asp Glu Lys Glu 
    210                 215                 220                 


Lys Tyr Glu Met Tyr Ile Leu Phe Ser Tyr Met Lys Glu Asp Lys Arg 
225                 230                 235                 240 


Thr Lys Asn Thr Asp Leu Leu Val Lys Ser Ile Ser Asn Gln Asn Thr 
                245                 250                 255     


Lys Val Lys Val Glu Asp Ile Asp Gly Asn Lys Leu Leu Lys Leu Ser 
            260                 265                 270         


Ile Ala Asp Thr Lys Lys Glu Pro Leu Trp Glu Tyr Leu Ile Lys Tyr 
        275                 280                 285             


Ala Asp Ser Ser Arg Gln Arg Glu Leu Met Tyr Asp Ile Arg Lys Lys 
    290                 295                 300                 


Ile Val Leu Tyr Val Val Gly Ile Glu Glu Tyr Glu Asn Ile Lys Glu 
305                 310                 315                 320 


Asp Ser Gly Leu Ser Lys Val Ser Trp Ser Lys Tyr Asn Ile Ser Asp 
                325                 330                 335     


Asn Lys Met Phe Phe Asp Ile Asn Ser Cys Thr Asp Lys Arg Lys Gln 
            340                 345                 350         


Asn Leu Glu Ile Lys Ile Arg Glu Ala Asn Ile Glu His Tyr Arg Asn 
        355                 360                 365             


Ala Ser Ser Lys Leu Cys Asp Asp Glu Ser Ile Phe Trp Phe Gln His 
    370                 375                 380                 


Phe Glu Gly Val Ile Glu Thr Leu Phe Ser Lys Lys Ser Lys Ile Ser 
385                 390                 395                 400 


Glu Glu Arg Leu Gly Cys Ala Tyr Ile Cys Asp Tyr Leu Trp Lys Asp 
                405                 410                 415     


Phe Leu Ser Tyr Leu Ala Ala Lys Tyr Ile Asp Leu Gly Lys Gly Val 
            420                 425                 430         


Tyr His Phe Thr Met Lys Asp Lys Leu Asp Met Leu Asn Lys Asn Glu 
        435                 440                 445             


Ala Val Thr Asp Leu Arg Phe Gly Ile Val Ser Glu Lys Tyr Glu Lys 
    450                 455                 460                 


Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Glu Leu 
465                 470                 475                 480 


Asp Arg Asn Ile Ala Ala Tyr Val Thr Phe Ala Ala Asp Ile Phe Ala 
                485                 490                 495     


Lys Ser Val Ile Lys Ser Asp Tyr Arg Thr Lys Lys Asp Asn Asn Ser 
            500                 505                 510         


Asp Val Leu Gln Tyr Ser Asp Lys Glu Phe Arg Asn Ser Glu Val Ile 
        515                 520                 525             


Arg Asp Asn Ala Glu Lys Asn Ile Leu Gln Tyr Trp Gly Gly Tyr Ser 
    530                 535                 540                 


Arg Trp Gly Thr Glu Asn Ser Lys Leu Pro Glu Asn Asn Lys Val Ser 
545                 550                 555                 560 


Asp Phe Gly Lys Leu Asp Val Ser Asp Leu Cys Ile Asp Ile Lys Lys 
                565                 570                 575     


His Leu Ala Gly Ile Arg Asn Ser Ser Val His Tyr Thr Thr Lys Ile 
            580                 585                 590         


Lys Asn Glu Ser Ala Ala Asp Gly Ser Asn Val Lys Ile Leu Phe Glu 
        595                 600                 605             


Lys Asp Leu Ala Asp Ile Asn Ile Ile Tyr Ala Asp Lys Tyr Tyr Ser 
    610                 615                 620                 


Asn Asn Val Trp Met Phe Tyr Ser Leu Glu Asp Ile Asn Lys Leu Ile 
625                 630                 635                 640 


Ala Phe Leu Tyr Lys Glu Lys Arg Val Ile Arg Gln Val Gln Ile Pro 
                645                 650                 655     


Ser Phe Ser Arg Ile Leu Lys Arg Lys Ala Met Gln Asp Val Ile Asn 
            660                 665                 670         


Glu Ile Phe Lys Asp Asp Phe Asp Glu Asn Ile Val Asn Pro Glu Leu 
        675                 680                 685             


Lys Glu Lys Tyr Arg Asn Ser Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
    690                 695                 700                 


Tyr Asn Ala Phe Ile Ile Gln Pro Glu Leu Lys Glu Lys Phe Lys Asp 
705                 710                 715                 720 


Lys Ile Lys Thr Met Lys Ser Glu Leu Tyr Asn Lys Leu Lys Thr Ile 
                725                 730                 735     


Asp Lys Lys Glu Tyr Lys Ala Leu Tyr Cys Met Leu Ser Asn Glu Glu 
            740                 745                 750         


Ser Ala Leu Lys Asn Phe Ala Asp Arg Ile Tyr Ser Val Asp Gly Asp 
        755                 760                 765             


Asn Val Ser Phe Ala Asp Ile Cys Lys Ile Leu Met Thr Asp Tyr Asn 
    770                 775                 780                 


Met Gln Asn Gln Glu Lys Lys Asn Ile Glu Ser Met Glu Gln Lys Lys 
785                 790                 795                 800 


Lys Asn Lys Gly Lys Asp Glu Asn Tyr Lys His Phe Pro Leu Leu Leu 
                805                 810                 815     


His Lys Val Leu Lys Glu Leu Phe Ile Glu Tyr Leu Lys Gln Thr His 
            820                 825                 830         


Glu Leu Glu Phe Leu Arg Asn Asn Ile Cys Ile Lys Ser Asp Val Thr 
        835                 840                 845             


Met Glu Ser Phe Glu Ser Gln Ile Lys Gly Val Glu Ile Tyr Lys Asp 
    850                 855                 860                 


Leu Lys Glu Lys Ile Asp Lys Asn Asn Ser Leu Leu Asp Trp Tyr Val 
865                 870                 875                 880 


Ile Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asn 
                885                 890                 895     


Ile Lys Asn Tyr Ile Gln Phe Ala Thr Asn Val Asp Lys Arg Ala Glu 
            900                 905                 910         


Ser Val Lys Asn Leu Thr Glu Ser Gly Met Val Lys Arg Ile Gln Tyr 
        915                 920                 925             


Tyr Asp Asp Ile Val Arg Thr Leu Glu Phe Ser Ala Gln Tyr Ile Gly 
    930                 935                 940                 


Lys Ile Ser Asn Asn Ile Asn Asp Tyr Phe Asn Ser Glu Asp Glu Tyr 
945                 950                 955                 960 


Val Ser Phe Leu Ser Lys Tyr Val Gly Phe Ile Asn Asp Lys Ser Glu 
                965                 970                 975     


Asp Val Leu Thr Glu Leu Lys Asp Phe Cys Arg Glu Lys Ile Asn Asn 
            980                 985                 990         


Gly Ser Gln Ile Ile Gly Ile Tyr  Tyr Gly Gly Asp Asn  Val Ile Ile 
        995                 1000                 1005             


Asn Arg  Asn Val Ile Tyr Ala  Gln Met Tyr Ser Asn  Ala Glu Val 
    1010                 1015                 1020             


Phe Ser  Asn Ile Tyr Lys Lys  Val Thr Lys Asn Asp  Ile Ile Asn 
    1025                 1030                 1035             


Tyr Tyr  Glu Lys Gln Asn Asp  Leu Lys Asp Val Phe  Lys Arg Gly 
    1040                 1045                 1050             


Val Cys  Gln Asn Glu Gly Glu  Gln Arg Ser Leu Cys  Glu Phe Gln 
    1055                 1060                 1065             


Gln Leu  Lys Asn Arg Ile Glu  Leu Thr Glu Leu Ser  Thr Tyr Ala 
    1070                 1075                 1080             


Asp Met  Val Asn Asp Phe Met  Ala Gln Phe Val Glu  Trp Ala Tyr 
    1085                 1090                 1095             


Leu Arg  Glu Arg Asp Leu Met  Tyr Phe Gln Leu Gly  Ile His Tyr 
    1100                 1105                 1110             


Ile Arg  Leu Phe Tyr Ser Asp  Asn Val Leu Asp Glu  Lys Tyr His 
    1115                 1120                 1125             


Lys Leu  Ser Asp Asn Val Ile  Asp Ile Glu Glu Gly  Ala Leu Leu 
    1130                 1135                 1140             


Tyr Gln  Ile Val Ala Met Tyr  Asp Tyr Glu Leu Arg  Ile Phe Glu 
    1145                 1150                 1155             


Thr Asp  Asn Ser Gly Asn Ala  Lys Arg Ile Gly Gln  Gly Gly Pro 
    1160                 1165                 1170             


Gly Lys  Ser Ile Pro Val Phe  Leu Lys Lys Tyr Cys  Asn Gly Thr 
    1175                 1180                 1185             


Asp Val  Tyr Glu Cys Gly Leu  Glu Leu Phe Glu Asp  Ile Asn Gln 
    1190                 1195                 1200             


His Glu  His Ile Ile Arg Phe  Arg Asn Asp Ile Ala  His Met Arg 
    1205                 1210                 1215             


Tyr Met  Ser Asn Gln Ala Met  Asn Ile Met Ser Ile  Val Ser Asn 
    1220                 1225                 1230             


Ile Tyr  Lys Ser Phe Phe Val  Tyr Asp Thr Lys Leu  Lys Lys Ser 
    1235                 1240                 1245             


Ile Ser  Leu Val Phe Lys Asn  Ile Leu Met Arg Tyr  Gly Val Ile 
    1250                 1255                 1260             


Ala Asp  Leu Val Phe Ser Tyr  Asn Asn Lys Asn Gln  Ser Ile Lys 
    1265                 1270                 1275             


Asp Asp  Met Asp Ile Asn Ile  Ile Asn Ile Lys Asn  Leu Lys Ser 
    1280                 1285                 1290             


Asp Lys  Tyr Val Tyr Lys Ile  Val Asn Glu Asp Ile  Val Lys Gln 
    1295                 1300                 1305             


Val Glu  Ile Glu Ile Arg Asn  Gln Val Phe Leu Glu  Gln Leu His 
    1310                 1315                 1320             


Asn Leu  Leu Tyr Phe Ser Arg  
    1325                 1330 


<210>  250
<211>  1169
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  250

Met Gln Ile Ile Lys Pro Tyr Gly Arg Ser His Val Glu Ala Asp Val 
1               5                   10                  15      


Ala Gly Gln Arg Lys Arg Ile Leu Ala Pro Arg Ser Asp Pro Asp Ser 
            20                  25                  30          


Arg Ile Asp Val Glu Thr Phe Ala Ser Ser Asp Asp Arg Leu Val Ile 
        35                  40                  45              


Ala Gln Trp Ile Ser Val Ile Asp Lys Ile Ala Arg Lys Pro Ser Ala 
    50                  55                  60                  


Gly Arg Ala Pro Ser Tyr Glu Gln Arg Ser Phe Arg Glu Lys Leu Gly 
65                  70                  75                  80  


Asp Ala Ala Trp Asp Arg Leu Val Ala Gly Gly Arg Leu Pro Gly Ala 
                85                  90                  95      


Ala Asp Pro Gly Lys Arg Glu Ala Leu Arg Glu Val Trp Gln Trp Lys 
            100                 105                 110         


Ile Ala Pro Tyr Ser Val Gly Glu Val Pro Gly Ser Arg Pro Ser Arg 
        115                 120                 125             


Ala Ser Ala Lys Gly Arg Trp Tyr Asp Arg Phe Pro Gly Ala Ala Val 
    130                 135                 140                 


Asp Val Gly Ala Ala Asp Thr Val Ala Met Ala Arg Gly Ile Glu Glu 
145                 150                 155                 160 


His Leu His Gly Gly Thr Ala Gly Arg Lys Gly Leu Ile Ala Ala Arg 
                165                 170                 175     


Ala Gln Ser Ile Ala Ala Asn Val Ala Arg Ala Pro Ser Pro Ala Tyr 
            180                 185                 190         


Ser Gly Gly Cys Gly Asp Gly Trp Thr Leu Glu Asp Glu Arg Tyr Tyr 
        195                 200                 205             


Ala Ala Ala Gly Asn Val Ala Leu Gln Ile Arg Gln Ala Ala Glu Leu 
    210                 215                 220                 


Arg Glu Gln Gly Lys Asp Pro Lys Lys Leu Arg Arg Val Ser Pro Asp 
225                 230                 235                 240 


Val Ala Gly Arg Ile Leu Tyr Ala His Tyr Gly Arg Leu Phe Arg Gly 
                245                 250                 255     


Pro Asp Gly Leu Ala Leu Lys Ile Ala Glu Ser Arg Ala Ala Ala Pro 
            260                 265                 270         


Gly Leu Phe Asn Leu His Cys Ala Val Lys Asp Ser Tyr Ser Arg Leu 
        275                 280                 285             


Leu Ser Arg Arg Leu Tyr Val Pro Glu Arg Asp Thr Gly Leu Pro Ala 
    290                 295                 300                 


Glu Thr Arg Pro Leu Ser Lys Leu Leu Pro Asp Thr Met Glu Ala Leu 
305                 310                 315                 320 


Phe Ala Leu Val Asp Ala Lys Gly Ala Asn Arg Asp Leu Asn Ala Leu 
                325                 330                 335     


Val Arg Leu Gly Lys Val Ile His Tyr Glu Ala Ala Gly Ser Asp Leu 
            340                 345                 350         


Asp Ala Pro Glu Ala Ala Val Ala Asn Trp Pro Ala Glu Val Glu Ser 
        355                 360                 365             


Ser Arg Tyr Trp Thr Ser Asp Gly Gln Leu Asp Ile Lys Arg Ser Glu 
    370                 375                 380                 


Ala Phe Val Arg Ile Trp Arg Arg Val Leu Gly Leu Ala Gly Arg Thr 
385                 390                 395                 400 


Leu Thr Asp Trp Ala Asp Pro Ala Gly Thr Ile Gly Gly Asp Ile Leu 
                405                 410                 415     


Met Arg Lys Gln Arg Glu Arg Ala Leu Gly His Glu Phe Asp Pro Asp 
            420                 425                 430         


Ala His Ala Arg Lys Leu Asp Leu Leu Phe Gly Gly Arg Ala Thr Ile 
        435                 440                 445             


Phe Ser Phe Ala Asp Glu Ala Asp Gln Arg Ala Leu Leu Asn Phe Ala 
    450                 455                 460                 


Leu Gln Gly Val Tyr Asp Leu Arg Asn Ala Ala Phe His Phe Thr Gly 
465                 470                 475                 480 


Ser Gly Gly Phe Ala Arg Ala Leu Ala Lys Cys Cys Arg Ala Ala Ala 
                485                 490                 495     


Pro Leu Val Leu Glu Ala Ala Arg Ser Leu Trp Ala Leu Asp Cys Ala 
            500                 505                 510         


Asp Arg Ser Arg Leu Gly Val Ala Ile Ala Arg Ala Ala Gln Phe Asp 
        515                 520                 525             


Arg Phe Phe Gly Glu Glu Glu Ile Ala Arg Leu Val Glu Ala Ala Ala 
    530                 535                 540                 


Gly Arg Arg Val Gly Ala Leu Pro Leu Pro Arg Leu Val Arg Val Leu 
545                 550                 555                 560 


Gln Arg Ala Gly Asn Ala Leu Ala Gly Thr Asp Ala Glu Ala Arg Arg 
                565                 570                 575     


Leu Asp Met Pro Ser Arg Ser Lys Leu Arg Asp Pro Ala Thr Phe Cys 
            580                 585                 590         


Arg Phe Glu Ala Leu Lys Leu Leu Tyr Glu Gly Pro Phe Arg Asp Trp 
        595                 600                 605             


Leu Ser Ser Arg Gly Ser Ala Asp Val Asn Gly Phe Ile Asp Phe Ala 
    610                 615                 620                 


Val Ala Arg Ser Thr Ala Ala Ala Arg Thr Leu Asn Gly Lys Gly Glu 
625                 630                 635                 640 


Ser Arg Arg Glu Ala Ser Ile Val Ser Arg Ala Ser Lys Leu Gly Arg 
                645                 650                 655     


Leu Arg Pro Gly Glu Thr Val Ser Asp Phe Phe Phe Arg Leu Ser Ala 
            660                 665                 670         


Glu Ser Ala Thr Glu Phe Arg Val Gln Arg Ala Tyr Gln Ser Asp Arg 
        675                 680                 685             


Gly Arg Ala Arg Ala Gln Ala Asp Tyr Ile Glu Lys Leu Lys Leu Asp 
    690                 695                 700                 


Val Val Ala Leu Pro Phe Gly Glu Phe Leu Ala Gly Ala Gly Phe Asp 
705                 710                 715                 720 


Phe Val Thr Glu Leu Ala Pro Gly Thr Ala Gln Ala Ala Gly Ser Ser 
                725                 730                 735     


Leu Ala Ile Ala Pro Pro Glu Ala Gly Ile Gly Pro Ala Ala Glu Gly 
            740                 745                 750         


Trp Gln Val Ala Leu Tyr Phe Phe Leu His Leu Val Pro Val Asp Asp 
        755                 760                 765             


Val Ala Arg Leu Met His Gln Val Gln Arg Trp Asp Ser Asn Ala Pro 
    770                 775                 780                 


Arg Ser Gly Ala Ala Ala Val Ser Ser Ala Gly Leu Leu Val Val Leu 
785                 790                 795                 800 


Ala Leu Tyr Cys Asp Met His Asp Ala Lys Phe Glu Gly Arg Ala Ala 
                805                 810                 815     


Leu Ser Gln Val Glu Pro Phe Arg Asp Leu Phe Glu Ser Pro Gly Asp 
            820                 825                 830         


Phe Asp Arg Ile Phe Pro Val Met Gly Pro Asp Glu Leu Arg Leu Ser 
        835                 840                 845             


Arg Arg Gly Leu Arg Glu Val Met Arg Phe Gly His Val Ala Pro Leu 
    850                 855                 860                 


Arg Ser Val Phe Arg Lys Gln Trp Ile Gly Thr Gly Asp Val Arg Glu 
865                 870                 875                 880 


Phe Leu Ala Ala Asn Arg Pro Asp Pro Asp Gly Ser Ser Pro Ile Ala 
                885                 890                 895     


Arg Leu Gln Ala Glu Arg Glu Ala Leu His Glu Leu Trp Val Arg Gln 
            900                 905                 910         


Gly Arg Gly Phe Thr Ala Ala Asp Arg Asp Arg Tyr Arg Val Val Leu 
        915                 920                 925             


Gly Gln Val Val Arg Tyr Arg His Leu Ala Ala His Val Thr Leu Thr 
    930                 935                 940                 


Asp His Ile Arg Leu His Arg Leu Leu Val Ala Ile Trp Ser Arg Leu 
945                 950                 955                 960 


Val Asp Phe Thr Gly Leu Trp Glu Arg Asp Leu Tyr Phe Val Thr Leu 
                965                 970                 975     


Ala Leu Ile His Phe Glu Gly Arg Thr Pro Arg Glu Ala Leu Gly Ser 
            980                 985                 990         


Lys Ala Leu Tyr Phe Leu Ala Arg  Gly Gln Ile Ile Glu  Ala Leu Arg 
        995                 1000                 1005             


Lys Ala  Arg Leu Ser Ala Phe  Ala Glu Ser Val Leu  Ser Leu His 
    1010                 1015                 1020             


Phe Thr  Gly Ile Trp Lys Glu  Gly Ser Arg Ala Thr  Arg Ile Arg 
    1025                 1030                 1035             


Asn Lys  Ile Ala His Phe Ala  Met Leu Arg Gln Ala  Asp Ala Pro 
    1040                 1045                 1050             


Asp Leu  Thr Tyr Trp Ile Asn  Gln Cys Arg Glu Leu  Leu Arg His 
    1055                 1060                 1065             


Asp Arg  Lys Leu Arg Asn Ala  Val Pro Ala Ser Ile  Lys Glu Leu 
    1070                 1075                 1080             


Leu Arg  Gln Thr Gly Ile Glu  Ile Glu Trp Arg Leu  Arg Gly Asp 
    1085                 1090                 1095             


Asp His  Asp Leu Gly Ala Ser  Arg Val Thr Thr Arg  Arg Ala Lys 
    1100                 1105                 1110             


His Leu  Gly Ser Gly Ser Val  Thr Glu Asp Leu Asn  Gly Glu Arg 
    1115                 1120                 1125             


Phe Val  Ala Met Thr Ala Ala  Leu Phe Gly Asp Ser  Ala Pro His 
    1130                 1135                 1140             


Thr Thr  Val Gln Arg Pro Pro  Arg Arg Ala Asp Ala  His Pro Gly 
    1145                 1150                 1155             


Arg Pro  Gln Phe Val Arg Pro  Ser Pro Arg Leu 
    1160                 1165                 


<210>  251
<211>  1250
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  251

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Pro Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Lys Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Asp Ile Gln Arg Ile Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Lys Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Thr Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Ile Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Ile Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Gln Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Lys 
                405                 410                 415     


Arg Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Ile Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Ala Leu Glu Gly Glu Ser 
    450                 455                 460                 


Val Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Glu Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Ala Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Lys Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Lys Asp Asp Glu Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Ser Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Lys Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Ala Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Val Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Glu Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Asp 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Lys Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  Ile Leu Tyr 
    1220                 1225                 1230             


Leu Ile  Cys Asp Tyr Pro His  Lys His Tyr Thr Phe  Lys His Phe 
    1235                 1240                 1245             


Glu Ala  
    1250 


<210>  252
<211>  1135
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  252

Met Lys Ile Thr Lys Ile Gly Gly Ile Ser His Lys Lys Tyr Glu Glu 
1               5                   10                  15      


Lys Gly Lys Leu Ile Lys Ser Asn Glu Ile Glu Lys Asp Val Ile Glu 
            20                  25                  30          


Glu Arg Phe Ser Asn Ile Glu Ala Lys Thr Thr Glu Leu Phe Ser Lys 
        35                  40                  45              


Thr Leu Asp Phe Tyr Val Lys Asn Tyr Glu Lys Cys Glu Glu Gln Asn 
    50                  55                  60                  


Lys Glu Arg Arg Glu Lys Ala Lys Asn Tyr Phe Ser Lys Val Lys Leu 
65                  70                  75                  80  


Ile Val Asp Asn Lys Lys Ile Thr Ile Phe Asn Glu Asn Thr Glu Lys 
                85                  90                  95      


Ile Glu Ile Glu Gly Phe Asn Glu Tyr Asp Val Arg Asp Glu Lys Tyr 
            100                 105                 110         


Phe Asn Val Leu Asn Lys Ile Leu Lys Glu Glu Asn Cys Thr Glu Glu 
        115                 120                 125             


Asp Leu Glu Val Phe Glu Asn Asp Leu Gln Lys Lys Leu Asn Gln Ile 
    130                 135                 140                 


Gln Ser Ile Lys Asn Ser Leu Glu Lys Asn Lys Ala His Phe Lys Lys 
145                 150                 155                 160 


Glu Ser Ile Asn Asn Thr Thr Asp Arg Val Lys Gly Asn Asn Lys Lys 
                165                 170                 175     


Ser Leu Phe Tyr Glu Tyr Tyr Arg Asn Ser Ser Lys His Gln Glu Tyr 
            180                 185                 190         


Val Asn Asn Ile Phe Glu Ala Phe Asp Lys Leu Tyr Ser Asn Ser His 
        195                 200                 205             


Glu Asp Ile Asn Asn Leu Phe Leu Glu Ile Thr Lys Asp Ser Asn Asn 
    210                 215                 220                 


Arg Asn Ile Arg Lys Ile Arg Glu Val Tyr Asn Glu Ile Leu Asn Lys 
225                 230                 235                 240 


Asn Lys Thr Glu Phe Gly Glu Glu Leu Tyr Lys Lys Ile Gln Asp Asn 
                245                 250                 255     


Ile Ser Asn Phe Asp Lys Leu Leu Glu Ile Glu Pro Glu Ile Lys Glu 
            260                 265                 270         


Leu Thr Lys Ser Gln Ile Phe Tyr Lys Tyr Tyr Ile Asp Lys Val Ser 
        275                 280                 285             


Leu Asp Gly Thr Asn Ile Lys His Cys Phe Ser His Leu Val Glu Ile 
    290                 295                 300                 


Glu Val Asn Gln Leu Leu Lys Asn Tyr Val Tyr Ser Lys Arg Ser Thr 
305                 310                 315                 320 


Asn Lys Glu Lys Leu Glu Asn Ile Phe Glu Tyr Cys Lys Leu Arg Asn 
                325                 330                 335     


Leu Val Lys Asn Lys Leu Val Asn Lys Leu Asn Asn Tyr Ile Arg Asn 
            340                 345                 350         


Cys Gly Lys Tyr Asn Ser Tyr Ile Asn Asn Asn Asp Val Val Asn Ser 
        355                 360                 365             


Glu Lys Ile Ser Glu Ile Arg Thr Lys Glu Ala Phe Leu Arg Ser Ile 
    370                 375                 380                 


Ile Gly Val Ser Ser Ser Ala Tyr Phe Ser Leu Arg Asn Ile Leu Asn 
385                 390                 395                 400 


Thr Asp Asn Thr Gln Asp Ile Thr Asn Lys Val Lys Gly Glu Val Glu 
                405                 410                 415     


Lys Leu Tyr Gln Glu Asn Lys Lys Val Lys Leu Glu Glu Arg Leu Lys 
            420                 425                 430         


Leu Phe Phe Gly Asn Asn Phe Asp Ile Asn Asn Gln Gln Glu Ile Glu 
        435                 440                 445             


Asp Phe Leu Met Asn Ile Asp Lys Ile Ile Ser Asn Ile Arg His Glu 
    450                 455                 460                 


Ile Ile His Phe Lys Ile Glu Ala Asn Ala His Ser Ile Phe Asp Phe 
465                 470                 475                 480 


Asn Asn Val Thr Leu Gly Asn Lys Ala Lys Asn Ile Phe Asn Asn Glu 
                485                 490                 495     


Ile Asn Glu Glu Arg Ile Lys Phe Lys Ile Phe Lys Gln Leu Asn Ser 
            500                 505                 510         


Ala Asn Val Phe Asp Tyr Leu Ser Asp Glu Asn Ile Thr Glu Tyr Met 
        515                 520                 525             


Gly Lys Val Ile Phe Ser Phe Thr Asn Arg Asn Ile Pro Phe Val Pro 
    530                 535                 540                 


Ser Phe Arg Lys Ile Tyr Asn Arg Val Gln Asp Leu Ala Asn Ser Leu 
545                 550                 555                 560 


Lys Ile Lys Glu Trp Lys Ile Ser Asp Glu Ser Glu Gly Lys Asp Ala 
                565                 570                 575     


Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asp Asp 
            580                 585                 590         


Phe Leu Asn Glu Lys Asn Glu Lys Phe Ile Lys Ile Lys Asp Glu Ile 
        595                 600                 605             


Ile Glu Leu Asn Lys Asn Gln Asn Lys Ile Thr Gly Phe Tyr Lys Leu 
    610                 615                 620                 


Glu Lys Phe Glu Lys Ile Glu Glu Lys Asn Pro Lys Lys Tyr Leu Glu 
625                 630                 635                 640 


Ile Ile Gln Ser Leu Tyr Met Ile Asn Ile Glu Glu Ile Asp Asn Glu 
                645                 650                 655     


Glu Lys Asn Ile Phe Leu Asp Phe Ile Gln Lys Ile Phe Leu Lys Gly 
            660                 665                 670         


Phe Phe Glu Phe Ile Lys Asn Asn Tyr Asn Tyr Leu Leu Glu Leu Lys 
        675                 680                 685             


Lys Ile Gln Asp Lys Lys Asn Ile Phe Asp Arg Glu Met Ser Glu Tyr 
    690                 695                 700                 


Ile Ala Gly Glu Lys Thr Leu Glu Asp Ile Gly Glu Ile Asn Glu Ile 
705                 710                 715                 720 


Ile Gln Lys Ile Glu Ile Thr Lys Ile Asp Lys Ile Leu Asn Leu Thr 
                725                 730                 735     


Asp Lys Ile Asn Cys Phe Tyr Leu Leu Leu Lys Leu Leu Asn Tyr Lys 
            740                 745                 750         


Glu Ile Thr Glu Leu Lys Gly Asn Leu Glu Lys Tyr Gln Ile Leu Ser 
        755                 760                 765             


Lys Thr Asp Ile Tyr Glu Lys Glu Leu Ile Leu Leu Asn Ile Val Asn 
    770                 775                 780                 


Leu Asp Asn Asn Lys Val Lys Ile Glu Lys Phe Lys Ile Ser Ala Glu 
785                 790                 795                 800 


Glu Ile Gly Lys Phe Ile Glu Lys Ile Ser Arg Asn Lys Lys Ile Lys 
                805                 810                 815     


Thr Phe Glu Glu Leu Arg Asn Phe Glu Lys Arg Glu Asn Thr Gly Glu 
            820                 825                 830         


Tyr Tyr Asn Val Tyr Ser Asp Asp Lys Asn Ile Lys Asn Ile Arg Asn 
        835                 840                 845             


Leu Tyr Asn Ile Lys Lys Tyr Gly Met Leu Asp Leu Leu Glu Arg Ile 
    850                 855                 860                 


Ser Glu Lys Ser Asn Tyr Cys Ile Lys Lys Glu Asp Leu Lys Glu Tyr 
865                 870                 875                 880 


Asp Lys Leu Lys Lys Lys Leu Glu Asp Lys Lys Thr Asp Phe Tyr Lys 
                885                 890                 895     


Ile Gln Lys Asp Leu His Tyr Lys Tyr Gln Lys Glu Tyr Lys Asn Phe 
            900                 905                 910         


Ser Lys Lys Asn Asn Thr Glu Asp Tyr Glu Lys Tyr Lys Glu Ser Ile 
        915                 920                 925             


Glu Asn Ile Glu Lys Tyr Val His Leu Lys Asn Lys Ile Glu Phe Asn 
    930                 935                 940                 


Glu Leu Asn Leu Leu Gln Ser Leu Leu Leu Lys Ile Leu His Arg Leu 
945                 950                 955                 960 


Val Gly Phe Thr Ser Ile Trp Glu Arg Asp Leu Arg Phe Arg Leu Ile 
                965                 970                 975     


Gly Glu Phe Pro Asp Glu Leu Asp Val Glu Asp Ile Phe Asp His Arg 
            980                 985                 990         


Glu Arg Tyr Arg Gly Thr Arg Gly  Gln Ile Cys Lys Lys  Tyr Asp Gln 
        995                 1000                 1005             


Phe Ile  Ser Val His Ile Glu  Tyr Gln Asn Asn Lys  Lys Met Lys 
    1010                 1015                 1020             


Asn Ile  Lys Phe Asp Asp Asn  Asn Pro Ile Arg Asn  Tyr Ile Ala 
    1025                 1030                 1035             


His Phe  Asn Tyr Leu Pro Thr  Pro Lys Tyr Ser Ile  Leu Lys Met 
    1040                 1045                 1050             


Leu Gly  Lys Leu Arg Glu Leu  Leu Asp Tyr Asp Arg  Lys Leu Lys 
    1055                 1060                 1065             


Asn Ala  Val Met Lys Ser Ile  Lys Asp Ile Leu Glu  Glu Tyr Gly 
    1070                 1075                 1080             


Phe Lys  Ala Glu Phe Val Ile  Asn Pro Asp Lys Glu  Ile Ile Leu 
    1085                 1090                 1095             


Asn Ser  Val Lys Ser Val Glu  Ile Ile His Leu Lys  Lys Asn Asp 
    1100                 1105                 1110             


Leu Asn  Ser His Arg Asn Ser  Glu Asp Leu Cys Lys  Leu Val Lys 
    1115                 1120                 1125             


Ala Met  Leu Glu Tyr Ser Glu  
    1130                 1135 


<210>  253
<211>  1186
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  253

Met Lys Val Thr Lys Ile Asp Gly Leu Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ile Glu Asp Ala Ser Gln Lys Asn Glu Thr 
            20                  25                  30          


Leu Glu Arg Leu Glu Lys Leu Lys Glu Ile Lys Leu Gly Asn Tyr Ile 
        35                  40                  45              


Lys Asn Pro Asp Lys Thr Lys Asp Lys Asp Asn Lys Lys Arg Arg Lys 
    50                  55                  60                  


Gly Leu Lys Glu Tyr Phe Ser Glu Ile Thr Leu Arg Lys Glu Asn Glu 
65                  70                  75                  80  


Lys Tyr Val Leu Leu Lys Gly Lys Lys Leu Lys Lys Ile Asn Asn Asp 
                85                  90                  95      


Ile Lys Asp Thr Asp Ile Lys Val Lys Tyr Lys Lys Glu Glu Val Phe 
            100                 105                 110         


Asp Val Leu Lys Lys Ile Leu Lys Leu Asn Leu Leu Ala Asn Asp Val 
        115                 120                 125             


Glu Glu Lys Ile Gln Phe Asp Ser Ile Lys Leu Lys Asn Val Phe Gly 
    130                 135                 140                 


Lys Asp Phe Val Lys Lys Glu Leu Gln Ile Lys Ser Ile Glu Glu Ser 
145                 150                 155                 160 


Leu Glu Lys Asn Lys Ala Asp Tyr Arg Lys Glu Phe Ile Glu Ile Glu 
                165                 170                 175     


Asn Asp Lys Tyr Gly Asn Val Lys Gly Glu Asn Lys Lys Asn Arg Ile 
            180                 185                 190         


Tyr Glu Tyr Tyr Lys Lys Ser Glu Thr His Glu Lys Phe Arg Lys Asn 
        195                 200                 205             


Ile Ile Glu Ala Phe Glu Lys Leu Tyr Lys Lys Asp Asp Ile Glu Lys 
    210                 215                 220                 


Leu Tyr Thr Gln Ile Ile Glu Ile Ser Lys Lys Met His Leu Lys Ser 
225                 230                 235                 240 


Lys Val Arg Glu Leu Tyr Lys Asn Val Ile Ile Lys Arg Ser Cys Asp 
                245                 250                 255     


Asp Phe Ser Lys Lys Asn Lys Glu Gly Ile Ser Val Leu Tyr Ser Gln 
            260                 265                 270         


Ile Met Asn Ser Val Lys Lys Asn Glu Lys Phe Val Lys Phe Val Lys 
        275                 280                 285             


Asn Ile Glu Leu Lys Asp Leu Thr Lys Ser Gln Ile Phe Tyr Lys Tyr 
    290                 295                 300                 


Phe Leu Glu Asn Glu Glu Leu Asn Asp Glu Asn Ile Lys Asn Ile Phe 
305                 310                 315                 320 


Cys Tyr Phe Val Glu Ile Glu Val Ser Asp Leu Leu Lys Gly Asn Val 
                325                 330                 335     


Tyr Lys Val Ser Lys Ile Tyr Glu Asn Lys Ile Lys Asn Ile Phe Glu 
            340                 345                 350         


Tyr Asn Lys Leu Lys Lys Leu Val Ile Asn Lys Leu Glu Asn Lys Leu 
        355                 360                 365             


Asn Asn Tyr Val Arg Asn Cys Gly Lys Tyr Asn Tyr His Met Glu Asn 
    370                 375                 380                 


Gly Asp Ile Ala Thr Ser Asp Ile Asn Met Arg Asn Arg Gln Thr Glu 
385                 390                 395                 400 


Ala Phe Leu Arg Ser Met Ile Gly Val Ser Ser Phe Gly Tyr Phe Ser 
                405                 410                 415     


Leu Arg Asn Ile Leu Gly Val Asn Asp Asp Asp Phe Tyr Glu Ile Glu 
            420                 425                 430         


Glu Asp Leu Thr Glu Glu Glu Arg Lys Asn Glu Ser Asn Val Leu Lys 
        435                 440                 445             


Lys Ala Lys Glu Asp Ile Thr Ser Lys Ser Ile Phe Glu Lys Val Val 
    450                 455                 460                 


Asp Lys Ser Phe Glu Lys Lys Gly Ile His Ser Ile Arg Glu Asn Val 
465                 470                 475                 480 


Lys Met Phe Tyr Gly Asp Ser Phe Asp Lys Ala Asn Glu Asp Glu Leu 
                485                 490                 495     


Lys Gln Phe Phe Val Asn Met Leu Asn Ala Ile Thr Ser Ile Arg His 
            500                 505                 510         


Arg Val Val His Tyr Asn Met Asn Thr Asn Ser Glu Asn Ile Phe Asn 
        515                 520                 525             


Phe Ser Asp Ile Glu Val Ser Arg Leu Leu Lys Ser Ile Phe Glu Lys 
    530                 535                 540                 


Glu Thr Asp Lys Arg Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn 
545                 550                 555                 560 


Ser Ala Gly Val Phe Asp Tyr Trp Glu Asn Trp Lys Ile Lys Lys Tyr 
                565                 570                 575     


Leu Glu Asn Met Lys Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val 
            580                 585                 590         


Pro Ser Phe Thr Lys Leu Tyr Asn Arg Ile Asp Asn Leu Lys Gly Ser 
        595                 600                 605             


Asn Ala Leu Asn Leu Gly Tyr Ile Asn Ile Pro Lys Arg Lys Glu Ala 
    610                 615                 620                 


Arg Asp Ser Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Lys Phe 
625                 630                 635                 640 


Val Glu Glu Phe Ile Lys Asn Asn Asp Asn Phe Glu Lys Ile Phe Arg 
                645                 650                 655     


Glu Ile Ile Glu Ile Asn Lys Asn Ala Gly Thr Asn Lys Gln Thr Asn 
            660                 665                 670         


Phe Tyr Lys Leu Glu Lys Phe Glu Lys Leu Lys Ala Asn Thr Pro Thr 
        675                 680                 685             


Glu Tyr Leu Glu Lys Leu Gln Ser Leu His Lys Ile Asn Tyr Asn Arg 
    690                 695                 700                 


Glu Lys Ile Glu Glu Asp Lys Asp Ile Tyr Val Asp Phe Val Gln Lys 
705                 710                 715                 720 


Ile Phe Leu Lys Gly Phe Ile Ser Tyr Leu Gln Lys Ser Asn Ser Leu 
                725                 730                 735     


Lys Pro Leu Asn Leu Leu Asn Leu Lys Lys Asp Glu Val Ile Asn Ser 
            740                 745                 750         


Glu Lys Ser Phe Tyr Asp Glu Lys Leu Lys Gln Trp Glu Asn Asn Gly 
        755                 760                 765             


Ser Asn Leu Ser Glu Met Pro Lys Glu Ile Tyr Lys Tyr Ile Lys Glu 
    770                 775                 780                 


Ile Lys Ile Asn Lys Thr Asn Tyr Ser Asp Arg Met Ser Ile Phe Tyr 
785                 790                 795                 800 


Leu Leu Leu Lys Leu Ile Asp His Lys Glu Leu Thr Asn Leu Arg Gly 
                805                 810                 815     


Asn Leu Glu Lys Tyr Glu Ser Met Asn Lys Asn Lys Ile Tyr Ser Glu 
            820                 825                 830         


Glu Leu Asn Ile Val Asn Leu Val Ser Leu Asp Asn Asn Lys Val Arg 
        835                 840                 845             


Thr Asn Phe Ser Val Glu Ala Glu Asp Ile Gly Lys Phe Leu Lys Thr 
    850                 855                 860                 


Glu Thr Ser Ile Lys Asn Ile Asn Gln Leu Asn Asn Phe Ser Gly Ile 
865                 870                 875                 880 


Phe Ala Asp Gly Glu Asn Val Ile Lys His Arg Ser Phe Tyr Asn Ile 
                885                 890                 895     


Lys Lys Tyr Gly Ile Leu Asp Leu Leu Glu Lys Ile Val Ala Lys Ala 
            900                 905                 910         


Asp Leu Lys Ile Ala Lys Glu Glu Ile Lys Lys Tyr Glu Asn Leu Gln 
        915                 920                 925             


Lys Glu Leu Glu Lys Asn Asp Phe Tyr Lys Ile Gln Glu Lys Ile His 
    930                 935                 940                 


Arg Lys Tyr Asn Gln Lys Pro Asn Leu Ile Ser Arg Thr Glu Asn Lys 
945                 950                 955                 960 


Lys Asp Phe Asn Asp Tyr Lys Lys Ala Ile Glu Asn Ile Gln Asn Tyr 
                965                 970                 975     


Thr Gln Leu Lys Asn Lys Ile Glu Phe Asn Asp Leu Asn Leu Leu Gln 
            980                 985                 990         


Gly Leu Leu Phe Arg Ile Leu His  Arg Leu Thr Gly Tyr  Thr Ser Leu 
        995                 1000                 1005             


Trp Glu  Arg Asp Leu Gln Phe  Lys Leu Lys Gly Glu  Phe Pro Glu 
    1010                 1015                 1020             


Asp Lys  Tyr Ile Asp Glu Ile  Phe Asn Ser Asp Arg  Asn Asn Asn 
    1025                 1030                 1035             


Gln Lys  Tyr Lys Ser Gly Gly  Ile Ala Tyr Lys Tyr  Val Asp Phe 
    1040                 1045                 1050             


Leu Ile  Glu Lys Glu Glu Gly  Lys Arg Ala Gly Lys  Asn Lys Val 
    1055                 1060                 1065             


Lys Lys  Arg Ser Glu Arg Glu  Arg Ser Phe Ile Ile  Arg Asn Tyr 
    1070                 1075                 1080             


Ile Ala  His Phe Asn Tyr Ile  Pro Asp Ala Glu Lys  Ser Ile Leu 
    1085                 1090                 1095             


Glu Ile  Leu Glu Glu Leu Arg  Glu Leu Leu Lys Tyr  Asp Arg Lys 
    1100                 1105                 1110             


Leu Lys  Asn Ala Val Met Lys  Ser Ile Lys Asp Ile  Phe Lys Glu 
    1115                 1120                 1125             


Tyr Gly  Phe Ile Ile Glu Phe  Gly Ile Ser His Glu  Ser Asn Ser 
    1130                 1135                 1140             


Lys Lys  Ile Lys Val Leu Asn  Val Glu Ser Gly Lys  Ile Lys His 
    1145                 1150                 1155             


Leu Lys  Asn Asn Gly Leu Val  Thr Thr Arg Asn Ser  Lys Asp Leu 
    1160                 1165                 1170             


Cys Lys  Leu Val Lys Val Met  Leu Glu Tyr Lys Lys  Ser 
    1175                 1180                 1185     


<210>  254
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  254

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Asn Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Ser Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Asn Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Glu 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Val Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Thr Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Lys Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Glu  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  255
<211>  1373
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  255

Met Ala Lys His Leu Arg Pro Ile Gly Glu Ser Tyr Thr Asp Phe Leu 
1               5                   10                  15      


Asp Glu Thr Glu Phe Val Arg Leu Gly Arg Gly Leu His Arg Gly His 
            20                  25                  30          


His Gly Val Gln Ile Pro Pro Thr Glu Leu Pro Ser Tyr Leu Ala Glu 
        35                  40                  45              


Tyr Arg Lys Ala Leu Met Arg Gln Val Val Ala Val Leu Asp Lys Val 
    50                  55                  60                  


Val Gly Lys Arg Arg Arg Leu Ser Gly Met His Pro Glu Ala Tyr Arg 
65                  70                  75                  80  


Asp Arg Val His Leu Ala Glu Ala Leu Trp Val Arg Leu Val Ala Arg 
                85                  90                  95      


Val Lys Glu Ile Gly Thr Pro Pro Asp Pro Ser Glu Leu Leu Asp Leu 
            100                 105                 110         


Arg Arg Met Trp Asn Ala Lys Ala His Pro Tyr Ala Glu Tyr Asp Val 
        115                 120                 125             


Val Pro Arg Ala Pro Leu Asn Asp Gly Asn Gly Gln Lys Ile Leu Glu 
    130                 135                 140                 


Cys Arg Glu Val Asp Asp Pro Lys Ile Glu Arg Ser Asp Phe Glu Gly 
145                 150                 155                 160 


Arg Trp His Gly Arg Phe Trp Gln Ser Glu Pro Gly Pro Val Asp Tyr 
                165                 170                 175     


Asn Ala Ile Ala Asp Arg Ile Phe Ala His Leu Phe Asp Gln Glu Ala 
            180                 185                 190         


Val Ile Gly Gly Gly Pro Arg Arg Glu Gly Asn Val Thr Val Pro Asp 
        195                 200                 205             


Glu Asp Ile Asn Gly Gln Pro Gly Pro Ala Thr Gly Lys Gly Leu Ile 
    210                 215                 220                 


Ile Ala Arg Gly Gln Ser Ile Val Lys Ser Ala Ser Asp Pro Arg Arg 
225                 230                 235                 240 


Ser Ser Lys Lys Val Gln Arg Thr Trp Asp Lys Ala Val Glu Arg Arg 
                245                 250                 255     


Tyr Phe Gly Asp Asp Gly Lys Gly Gly Ser Asp Ile Ala Lys Ala Ile 
            260                 265                 270         


Tyr Glu Glu Leu Gly Asp Pro Ala Thr Leu Ala Asp Pro Ile Tyr Ala 
        275                 280                 285             


Ser Trp Phe Gly Ser Arg Leu Tyr Asp His Phe Gly Ser Phe Lys Asn 
    290                 295                 300                 


Ser Leu Pro Leu Glu Leu Lys Asp Pro Phe Lys Glu Gln Ile Trp Ala 
305                 310                 315                 320 


Leu His Asn Ser Val Arg Gln Phe Tyr Gln Arg Met Ala Lys Ser Asp 
                325                 330                 335     


Arg Phe Arg Leu Ala Leu Gln Asn Ala Arg Ser Glu Val Pro Asp Arg 
            340                 345                 350         


Ser Glu Leu Leu Ala Leu Leu Pro Lys Asp His Asp His Leu Leu Leu 
        355                 360                 365             


Val Leu Gly Gly Lys Lys Lys Asn Ala Glu Met Ser Glu Leu Ile Arg 
    370                 375                 380                 


Leu Gly Lys Leu Phe Val His Ala Ser Asp Val Leu His Asp Phe Asp 
385                 390                 395                 400 


Ala Asn Asp Ala Ala Ala Leu Asp Ala Phe Lys Arg Arg Met Ser Phe 
                405                 410                 415     


Leu Ala Thr Ser Ile Gly Gln Ser Glu Ile Lys Gln Thr Glu Thr Phe 
            420                 425                 430         


Ala Arg Thr Trp Arg Gly Ala Val Gly Leu Thr Leu Arg Thr Val Lys 
        435                 440                 445             


Gly Leu Ala Asp Pro Arg Gly Ile Ile Gly Thr Pro Asp Asn Arg Asp 
    450                 455                 460                 


Leu Gly Thr Ala Gly Pro Met Lys Asp Ala Phe Asn Lys Phe Asp Gln 
465                 470                 475                 480 


Pro His Phe Gln Gln His Met Thr Ile Ile Phe Gly Asn Lys Glu Leu 
                485                 490                 495     


Gln Ala Glu Gly Asn Pro Thr Arg Ser Ser Val Phe Thr Ala Asn Gly 
            500                 505                 510         


Asp Lys Asp His Gln Ala Glu Leu Leu Trp Gly Phe Leu Cys Val Val 
        515                 520                 525             


Arg Ser Val Arg Asn Arg Thr Asn His Tyr Asn Val Arg Arg Ala Leu 
    530                 535                 540                 


Leu Arg Leu Leu Asp Glu Gly Ile Val Ser Pro Met Pro Ser Asp Pro 
545                 550                 555                 560 


Lys Lys Glu Arg Val Glu Asn Arg Asn Leu Cys Thr Val Ser Pro Thr 
                565                 570                 575     


Ala Leu Glu Ala Phe Arg Arg Leu Leu Asn Phe Asp Leu Ala Ile Gln 
            580                 585                 590         


Lys Glu Ala Val Arg Thr Ala Leu Glu Gln Ala Lys Ala Ser Glu Phe 
        595                 600                 605             


Val Glu Glu Gly Lys Leu Arg Gly Leu Val Ser Glu Leu Ala Gly Thr 
    610                 615                 620                 


Glu Asp Met Pro Ala Leu His Ile Pro Arg Phe Ser Ala Val Met Asp 
625                 630                 635                 640 


Lys Val Arg Arg Leu Ala Asp Asn Arg Asp Val Gly Leu Asp Pro Ile 
                645                 650                 655     


Leu Ser Thr Leu Gln Arg Ser Leu Pro Pro Thr Asp Lys Gln Ala Glu 
            660                 665                 670         


Ser Asp Ala Ala Arg Cys Arg Tyr Arg Leu Leu Leu Glu Leu Tyr Lys 
        675                 680                 685             


Ser Gly Phe Arg Ser Trp Phe Ser Gly Ile Gln Ser Asn Glu Glu Asn 
    690                 695                 700                 


Asn Arg Glu Ile Cys His Trp Ala Val Lys Gln Val Gly Arg Ala Lys 
705                 710                 715                 720 


Asp Ala Arg Lys Ser Glu Tyr Asp Lys Lys Thr Lys Arg His Tyr Arg 
                725                 730                 735     


Ser Pro Asn Ser Leu Ile Asp Asp Leu Gly Leu Asp Lys Phe Asp Asp 
            740                 745                 750         


Leu Thr Asp Leu Leu Glu Ala Leu Ala Ser Gln Ser Thr Arg Glu His 
        755                 760                 765             


Asp Gln Asn Leu Lys Tyr Val Pro Asp Ala Arg Val Gln Ser Gln Met 
    770                 775                 780                 


Ser Asn Arg Ile Glu Glu Phe Arg Gln Glu Leu Phe Ala His Ile Phe 
785                 790                 795                 800 


Thr Lys Tyr Leu Asp Thr His Asp Phe Gly Trp Ile Gly Ala Ile Glu 
                805                 810                 815     


Val Arg Arg Glu Ala Cys Asp Leu Ala Asp Val Val Ser Ala Phe Glu 
            820                 825                 830         


Val Arg Asp Gln Lys Phe Asp Ala Asp Trp His Ser Gln Phe Tyr Ala 
        835                 840                 845             


Trp Leu Tyr Met Val Pro Pro Ile Glu Ala Ser Arg Leu Arg His Gln 
    850                 855                 860                 


Met Arg Lys Ser Ala Val Met Asp Asp Lys Trp Ser Thr Thr Leu Glu 
865                 870                 875                 880 


Leu Thr Ser Gly Asp Arg Lys Thr Arg Asp Asp His Ala Gln Asp Val 
                885                 890                 895     


Leu Ala Asp Met Asp Arg Leu Phe Ser Leu Tyr Thr Lys Val Gln Ala 
            900                 905                 910         


Ala Gly Phe Asn Gly Gln Glu His Glu Ser Ala Leu Gly Ser Lys Ser 
        915                 920                 925             


Leu Phe Tyr Glu Asp Gly Asn Gln Phe Asp Glu Val Tyr Ser Pro Asp 
    930                 935                 940                 


Thr Glu Thr His Asn Lys Thr Phe Pro Gly Thr Arg Arg Gly Leu Arg 
945                 950                 955                 960 


Gln Leu Val Arg Tyr Ala His Leu Pro Ala Leu Glu Gly Val Phe Lys 
                965                 970                 975     


Lys His Arg Ile Thr Lys Ala Glu Val Glu Thr Phe Val Ala Leu Tyr 
            980                 985                 990         


Asp Glu Asn Arg Arg Asp Pro Gly  Ser Val Ala His Met  Leu Arg Arg 
        995                 1000                 1005             


Glu Lys  Leu Arg Thr Glu Ile  Leu Arg Ser Ile His  Asp Gly Pro 
    1010                 1015                 1020             


Lys Pro  Lys Asp Lys Asp Phe  Trp Pro Lys Leu Glu  Ala Lys Cys 
    1025                 1030                 1035             


Leu Glu  Tyr Arg Thr Val Ala  Thr Glu Thr Ala Ile  Tyr Asn Phe 
    1040                 1045                 1050             


Gln Ala  Asn Ala Ala Arg Leu  Asn Asp His Ala Arg  Leu His Gln 
    1055                 1060                 1065             


Ile Val  Met Arg Val Val Ala  Arg Leu Thr Asp Tyr  Ala Leu Ile 
    1070                 1075                 1080             


Trp Glu  Arg Asp Arg Leu Phe  Ala Phe Val Gly Met  Leu Tyr Arg 
    1085                 1090                 1095             


Gln Thr  Gly Gly Thr Gly Ile  Asn Pro Ala Met Arg  His Ala Glu 
    1100                 1105                 1110             


Lys Thr  Asn Ala Pro Pro Arg  Ile Gly Ile Leu Val  Ser Asp Ser 
    1115                 1120                 1125             


Ala Leu  Ala Lys Lys Leu Asn  Ser Asn Ser Ala Glu  Val Phe Ile 
    1130                 1135                 1140             


Pro Tyr  Leu Asp Thr Glu Thr  Gly Phe Asp Ala Pro  Arg Phe Asp 
    1145                 1150                 1155             


Asp Leu  Cys Thr Leu Leu Ser  His Glu His Ala Lys  Glu Phe Arg 
    1160                 1165                 1170             


Phe His  Phe Leu Glu Val Gly  Glu Glu Asn Ser Lys  Asp Glu Ala 
    1175                 1180                 1185             


Arg Arg  Leu Asn Glu Glu Thr  Met Gly His Arg Lys  Arg Pro Ala 
    1190                 1195                 1200             


Phe Lys  Arg Gly Thr Arg Arg  Gln Gly Ile Arg Asn  Asp Leu Ala 
    1205                 1210                 1215             


His His  Asn Val Leu Asp Leu  Ala Gly Gly Ala Gly  Pro Asn Leu 
    1220                 1225                 1230             


Thr Tyr  Val Val Asn Ala Val  Arg Ser Leu Leu Ser  Tyr Asp Arg 
    1235                 1240                 1245             


Lys Leu  Lys Asn Ala Val Pro  Lys Ser Ile Lys Arg  Ile Leu Gly 
    1250                 1255                 1260             


Glu Glu  Gly Leu Ile Ile Glu  Trp Gln Met Asn Tyr  Asp Arg Leu 
    1265                 1270                 1275             


Lys Lys  Pro Thr Val Tyr Pro  Asn Val Glu Thr His  Leu Thr Met 
    1280                 1285                 1290             


Val Pro  Pro Arg His Met Thr  Ala Pro Val Ser Phe  Thr Leu Pro 
    1295                 1300                 1305             


Arg Ala  Ser Val Arg Leu Ala  Ser Met Val Lys Ala  Val Phe Asp 
    1310                 1315                 1320             


Phe Gly  Ser Ser Gly Tyr Gly  Glu Glu Arg Met Ile  Gly Gly Arg 
    1325                 1330                 1335             


Thr Ala  Lys Gln Ala Val Tyr  Pro Asp Asp Phe Thr  Arg Arg Phe 
    1340                 1345                 1350             


Pro Gln  Thr Pro Met Gly Leu  Lys Gln Ala Thr Arg  Leu Val Phe 
    1355                 1360                 1365             


Ala Ser  Glu Asn Ser 
    1370             


<210>  256
<211>  1287
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  256

Met Arg Ile Gly Lys Val Gln Gly Arg Thr Phe Thr Gly Phe Asp Asn 
1               5                   10                  15      


Ala Arg Gly Lys Thr Leu Arg Arg Arg Leu Leu Thr Arg Pro Asp Asn 
            20                  25                  30          


Glu Ala Arg Ser Leu Ser Glu His Leu Ala His Asp Pro Lys Ala Leu 
        35                  40                  45              


Ile Gly Gln Ala Ile Ser Arg Ile Asp Thr Ile Tyr Gln Lys Pro Lys 
    50                  55                  60                  


Thr Gly Lys Pro Thr Pro Glu Gln Phe Gly His Arg Asp Thr Leu Gly 
65                  70                  75                  80  


Trp Ala Tyr Trp Lys Leu Leu Val Ala Ser Tyr Pro Glu Val Glu Gly 
                85                  90                  95      


His Arg Asp Leu Phe Val Arg Arg Leu His Pro Tyr Gly Asp Thr Pro 
            100                 105                 110         


Pro Lys Ser His Gly Gln Lys Glu Gly Glu His Gln Lys Gly Gly Lys 
        115                 120                 125             


Pro Gln Leu Glu Gly Arg Trp His Gly Val Met Ala Gln His Gly Lys 
    130                 135                 140                 


Asn Pro Asp Gln Ile Ala Ala Arg Leu Phe Asp His Leu His Asn Ser 
145                 150                 155                 160 


Glu Leu Arg Phe Gly Gly Thr Ala Ser Gly Glu Pro Arg Thr Arg Pro 
                165                 170                 175     


Gly Lys Glu Ala Thr Pro Thr Gly Leu Ile Gly Ala Arg Ala Lys Thr 
            180                 185                 190         


Ile Glu His Ser Val Leu Pro Arg Asp Ala Lys Arg Phe Val Ala Glu 
        195                 200                 205             


Trp Arg Gly Glu Asp Gln Glu Arg Tyr Ala Gly Ala Arg Asp Ile Ala 
    210                 215                 220                 


Ala Ala Ile Ser Ala Gly Leu Asn Asp Lys Asp Gln Lys Ser Gly Ser 
225                 230                 235                 240 


Gly Arg Lys Ser Ala Val Ile Gly Lys Leu Leu Ser Asp His Leu Glu 
                245                 250                 255     


Thr Leu Thr Gly Asn Arg Lys Cys Arg Phe Asp Pro Lys Ser Thr Ala 
            260                 265                 270         


Glu Thr Leu Glu Leu Arg Asp Gly Glu Ser Val Asp Asp Arg Arg Arg 
        275                 280                 285             


Ile Leu Glu Leu His Ala Glu Val Lys Ala Thr Tyr Lys Arg Met Ala 
    290                 295                 300                 


Ala Trp Lys Pro Ala Lys Leu Pro Arg Asn Ser Asp Glu Leu Phe Arg 
305                 310                 315                 320 


Leu Val Arg Gln Gln Ala Asp Asn Arg Ile Leu Asn His Leu Val Arg 
                325                 330                 335     


Val Gly Arg Ile Ser Val Tyr Ser Glu Gln Ser Asp Ala Leu Ser Glu 
            340                 345                 350         


Ser Gln Phe Trp Thr Ser Gly Gly Gln Thr Gln Ile Lys Glu Ser Glu 
        355                 360                 365             


Val Phe Ala Arg Leu Trp Ile Gly Ala Ile Ser Arg Ala Ser Tyr Ser 
    370                 375                 380                 


Met Lys Ala Trp Leu Glu Pro Glu Gly Thr Val Phe Asn Pro Ser Ile 
385                 390                 395                 400 


Asn Asp Phe Asp Val Thr Ser Ser His Asn Thr Asn Arg Ile Leu Glu 
                405                 410                 415     


Asp Ser Gly Arg Leu Ser Asn Ala Met Ala Arg Arg Ala Ile Tyr Phe 
            420                 425                 430         


Gly Glu Thr Pro Glu Phe Asp Ala Leu Gly Glu Glu Asp Gln Arg Val 
        435                 440                 445             


Leu Val Lys Lys Cys Leu Asp Ala Leu Ser Ala Cys Arg Asn Arg Thr 
    450                 455                 460                 


Phe His His Gly Gln Arg Ala Lys Phe Leu Lys Glu Val Arg Lys Gly 
465                 470                 475                 480 


Leu Lys Glu Lys Glu Ala Asp Ser Ala Gly Pro Ala Ala Trp Glu Gly 
                485                 490                 495     


Ile Arg Glu Val Ile Gln Ala Asp Ala Arg Asn Leu Gly Ala Arg Leu 
            500                 505                 510         


Leu Gln Asp Leu Thr Gly Ala Lys Val His Ser Phe Ala Thr Asp Pro 
        515                 520                 525             


Glu Phe Arg His Leu Tyr Glu Ser Val Ala Ala Thr Leu Thr Ala Gly 
    530                 535                 540                 


Gly Glu Leu Glu Ala Ala Leu Pro Arg Leu Lys Asn Val Leu Lys Arg 
545                 550                 555                 560 


Ala Glu Gly Val Arg Cys Tyr Leu Asp Thr Pro Ser Gln Arg Arg Glu 
                565                 570                 575     


Gly Asp Glu Ser Leu Ile Ala Arg Leu Pro Val Ala Pro Val Pro Arg 
            580                 585                 590         


Glu Leu Asp Asp Ala Ala Thr Lys Ala Arg His Ser Ala Leu Leu Arg 
        595                 600                 605             


Leu Tyr Asp Gly Pro Phe Arg Pro Trp Ala Thr Glu Leu Arg Gly Glu 
    610                 615                 620                 


Arg Leu Ser Asp Tyr Ala Ala Arg Ala Lys Arg Leu Ala Thr Arg Leu 
625                 630                 635                 640 


Ala Lys Ser Thr Asn Thr Ala Ser Pro Tyr Pro Asp Ser Val Glu Gly 
                645                 650                 655     


Arg Ser Val Arg Leu Arg Asp Pro Ile Thr Ala Asp Thr Ala Pro Glu 
            660                 665                 670         


Thr Leu Lys Thr Tyr Leu Ser Ala Leu Thr Ala Glu Thr Ala Thr Glu 
        675                 680                 685             


Phe Arg Val Gln Lys Gly Tyr Glu Ser Asp Gly Glu Lys Ala Lys Glu 
    690                 695                 700                 


Gln Ala Glu Phe Ile Glu Asp Phe Arg Arg Asp Met Ile Ala Leu Ala 
705                 710                 715                 720 


Phe Gln Asp Phe Ile Arg Asp His Gly Phe Ala Trp Leu Leu Asp Ile 
                725                 730                 735     


Ala Ser Lys Ala Glu Pro Ser Asn Asp Ala Pro Asn Leu Pro Asp Pro 
            740                 745                 750         


Val Asp Thr Gly Lys Asp Thr Val Phe Glu Asp Trp Gln Ala Leu Leu 
        755                 760                 765             


Tyr Leu Phe Leu His Phe Val Pro Ala Asp Asp Val Ser Gln Leu Leu 
    770                 775                 780                 


His Gln Leu Arg Lys Trp Asp Ala Leu Gln Asp Lys Tyr Glu Leu Ala 
785                 790                 795                 800 


Glu Pro Gly Glu Thr Leu Gly Gln Thr Lys Ala Asp Thr Arg Lys Ile 
                805                 810                 815     


Val Gly Gln Phe Arg Asp Cys Leu Thr Leu Phe Leu Lys Thr Gly Asp 
            820                 825                 830         


Ala Arg Phe Asp Gly Glu Gly Val Glu Leu Pro Leu Ser Asp Phe Gln 
        835                 840                 845             


Glu Leu Phe Glu Ser Pro Ala Thr Phe Lys Glu Leu Phe Leu Ala Glu 
    850                 855                 860                 


Pro Ala Glu Asn Asp Ala Ser Glu Thr Asp Asp Gln Asp Ala Pro Gly 
865                 870                 875                 880 


Glu Lys His Arg Val Thr Arg Thr Arg Arg Gly Leu Arg Gln Ile Leu 
                885                 890                 895     


Arg Tyr Asn His Met Pro Val Leu Arg Asp Leu Phe Leu Ala His Lys 
            900                 905                 910         


Val Thr Asp Ala Glu Val Asp Gly Leu Gln Ala Leu Glu Val Asp Asp 
        915                 920                 925             


Pro Gln Thr Gly Glu Ser Gln Ile Gly Ala Ala Gln Arg Ile Arg Thr 
    930                 935                 940                 


Glu Ile His His His Thr Ser Asn Asp Lys Gln Ile Ser Glu Ala Lys 
945                 950                 955                 960 


Val Glu Glu Tyr Arg Arg Ala Leu Ser Thr Ile Glu Arg His Arg Phe 
                965                 970                 975     


Leu Val Gly Arg Val Tyr Leu Gly Asp His Ile Arg Val His Lys Leu 
            980                 985                 990         


Met Met Asp Val Met Gly Arg Leu  Val Asp Phe Ala Gly  Ala Trp Glu 
        995                 1000                 1005             


Arg Glu  Ala Ala Asp Gly Asp  Arg Lys Gly Phe Ile  Ser Arg Ala 
    1010                 1015                 1020             


Ile Ala  Leu Pro Glu Val Ala  Glu Gly Tyr Ala Ala  Asp Arg Leu 
    1025                 1030                 1035             


Lys Thr  Val Ala Arg Arg Val  Leu Asp Asp Gly Glu  Ala Arg Arg 
    1040                 1045                 1050             


Ile Arg  Asn Asp Leu Gly His  Phe Asn Asp Leu Ala  Pro Thr Ser 
    1055                 1060                 1065             


Gly Pro  Ala Asn Leu Thr Phe  Val Val Asn Arg Ala  Arg Arg Met 
    1070                 1075                 1080             


Met Arg  His Asp Arg Lys Arg  Lys Asn Ala Val Thr  Lys Ser Val 
    1085                 1090                 1095             


Ile Glu  Ile Leu Asn Arg Gln  Gly Leu Gly Ile Glu  Trp Thr Met 
    1100                 1105                 1110             


Arg Asn  His Glu Leu Cys Glu  Ala Lys Leu Trp Gln  Asn Pro Val 
    1115                 1120                 1125             


Lys His  Leu Gly Phe Ala Thr  Leu Glu Gly Arg Gly  Lys Lys Trp 
    1130                 1135                 1140             


Arg Arg  Pro Phe Glu Ala Arg  Tyr Gly Asp Ala Tyr  Met Ala Met 
    1145                 1150                 1155             


Val Ala  Gln Leu Phe Asp Gly  Thr Val Thr Ser Pro  Pro Ala Lys 
    1160                 1165                 1170             


Gly Pro  Pro Gln Ser Gly Lys  Ser Gly Gly Lys Pro  Gly Lys Gly 
    1175                 1180                 1185             


Ala Glu  Gly Gly Ala Lys Glu  Lys Ser Arg Ser Pro  Thr Arg Met 
    1190                 1195                 1200             


Glu Glu  Gly Gly Val Tyr Glu  Gly Arg Val Ala Lys  Ala Lys Ser 
    1205                 1210                 1215             


Asp Lys  Gly Phe Gly Phe Leu  Leu Val Glu Gly Ala  Gln Glu Glu 
    1220                 1225                 1230             


Ile Phe  Leu His Ile Tyr Gly  Ile Ser Gly Asn Arg  Pro Ala Arg 
    1235                 1240                 1245             


Ile Glu  Asn Gly Gln Arg Tyr  Arg Phe Thr Leu Gly  Ile Asp Arg 
    1250                 1255                 1260             


Asp Arg  Glu Arg Arg Lys Glu  Arg Ala Trp Val Ala  Arg Glu Ala 
    1265                 1270                 1275             


Val Arg  Ile Asp Glu Asn Arg  Ser Lys 
    1280                 1285         


<210>  257
<211>  1268
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  257

Met Lys Val Ser Lys Val Asn His Arg Lys Ala Ala Val Ala Val Asn 
1               5                   10                  15      


Lys Lys Ser Val Thr Val Asn Gly Ile Leu Tyr Asp Ala Pro Val Lys 
            20                  25                  30          


Lys Asn Val Lys Thr Gly Asn Met Ser Ala Tyr Val Ser Ser Lys Tyr 
        35                  40                  45              


Val Ile Asp Asn Val Val Lys Asn Ser Ser Arg Leu Tyr Ser Pro Phe 
    50                  55                  60                  


Ser Ser Lys Arg Ile Val Ile Asp Arg Glu Lys Ile Arg Ile Ala Asp 
65                  70                  75                  80  


Arg Leu Lys Gln Cys Tyr Val Asn Phe Val Lys Tyr Tyr Leu Ser Asn 
                85                  90                  95      


Gly Ser Leu Asn Glu Gln Gln Met Arg Phe Asn Pro Asn Asn Thr Tyr 
            100                 105                 110         


Met Thr Asp Ser Arg Val His Phe Cys Ala Pro Ser Gly Ile Asp Lys 
        115                 120                 125             


Glu Ser Leu Ile Asn Ser Ile Val Asp Ser Ser Leu Arg Lys Ser Leu 
    130                 135                 140                 


Lys Arg Thr Tyr Arg Phe Glu Thr Asn Tyr Gly Glu Lys Ile Thr Phe 
145                 150                 155                 160 


Asn Leu Pro Asp Leu Val Lys Lys Ser Ile Lys Ile Tyr Cys Thr Asp 
                165                 170                 175     


Glu Lys Arg Lys Leu Asn Asp Arg Glu Glu Gln Glu Met Tyr Val Leu 
            180                 185                 190         


Phe Ser Tyr Met Tyr Glu Asp Lys Tyr Lys Asp Arg Gln Lys Val Leu 
        195                 200                 205             


Ile Ala Asn Ser Ile Ser Asn Gln Ala Thr Lys Val Lys Val Cys Asp 
    210                 215                 220                 


Asp Glu Ser Ser Leu Ile Lys Leu Ser Ile Ala Asp Thr Lys Lys Lys 
225                 230                 235                 240 


Pro Leu Trp Asp Phe Ile Val Asp Tyr Ala Asn Ser Asp Lys Asn Gly 
                245                 250                 255     


Gln Tyr Thr Ile Leu Arg Asn Ile Arg Lys Ser Ile Val Leu Phe Val 
            260                 265                 270         


Cys Gly Val Asp Val Tyr Arg Asn Ile Glu Asn Asn Asp Asn Leu Asp 
        275                 280                 285             


Ile Trp Lys Trp Glu Glu Tyr Gly Ile Gln Glu Ser Gln Leu Phe Val 
    290                 295                 300                 


Lys Ile Glu Asn Cys Tyr Thr Thr Lys Asp Glu Asp Ile Ala Leu Asn 
305                 310                 315                 320 


Glu Ile Arg Asn Val Asn Leu Asp His Tyr Met Lys Ala Ile Gly Val 
                325                 330                 335     


Leu Asp Asp Glu Arg Ser Lys Phe Trp Phe Gln His Tyr Glu Asn Thr 
            340                 345                 350         


Ile Glu Ala Leu Phe Ser Lys Lys Ser Lys Arg Lys Ile Glu Arg Ile 
        355                 360                 365             


Lys Thr Val Tyr Leu Cys Glu Tyr Leu Trp Lys Asn Phe Cys Ser Tyr 
    370                 375                 380                 


Val Ala Leu Lys Tyr Ile Asp Leu Gly Lys Gly Val Tyr His Phe Thr 
385                 390                 395                 400 


Met Ser Asp Lys Leu Ser Leu Met Asn Lys Asn Thr Asn Glu Asn Gly 
                405                 410                 415     


Ile Lys Phe Gly Glu Val Asp Ser Arg Phe Asn Lys Gly Ile Ser Ser 
            420                 425                 430         


Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Thr Ile Asp Arg Asn Ile 
        435                 440                 445             


Ser Thr Tyr Thr Thr Phe Ala Thr Asn Ile Phe Ala Lys Ser Val Ile 
    450                 455                 460                 


Lys Asp Ser Tyr Ile Gln Lys Lys Ala Gly Asn Ser Asp Ala Leu Gln 
465                 470                 475                 480 


Tyr Asp Gly Glu Thr Tyr Tyr Asn Arg Lys Ala Ile Asn Pro Asp Ala 
                485                 490                 495     


Leu Lys Arg Val Leu Gln Tyr Trp Gly Gly Gln Ser Arg Trp Lys Ser 
            500                 505                 510         


Glu Leu Glu Glu Leu Asn Val Ala Glu Leu Cys Ile Asp Ile Lys Asn 
        515                 520                 525             


Arg Leu Ser Lys Ile Arg Asn Ser Gly Val His Tyr Thr Ser Thr Ser 
    530                 535                 540                 


Ala Leu Lys Gly Asn Asp Asp Asp Ser Ile Val Gly Met Leu Ile Lys 
545                 550                 555                 560 


Lys Asp Phe Asp Asp Ile Lys Asp Val Tyr Ala Ser Lys Tyr Tyr Ser 
                565                 570                 575     


Asn Asn Val Trp Met Phe Tyr Asn Thr Asp Lys Ile Ser Lys Met Met 
            580                 585                 590         


Glu Tyr Leu Tyr Gln Asp Asp Ser Asn Ile Arg Asp Ala Gln Ile Pro 
        595                 600                 605             


Ala Phe Asn Ser Val Ile Lys Arg Lys Asp Met Ala Glu Val Ile Glu 
    610                 615                 620                 


Lys Ile Ile Lys Lys Asn Ser Tyr Lys Thr Ile Lys Glu Pro Tyr Gln 
625                 630                 635                 640 


Arg Glu Lys Tyr Arg Ser Cys Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
                645                 650                 655     


Tyr Asn Arg Phe Ile Lys Gln Asp Asp Leu Lys Asp Gln Val Ile Gln 
            660                 665                 670         


Ile Ile Asp Ser Asn Thr Glu Leu Ile Gly Asp Asn Ser Arg Ala Val 
        675                 680                 685             


Asp Asn Leu Lys Lys Arg Ile His Asp Val Asp Ser Gln Thr Met Ser 
    690                 695                 700                 


Phe Gly Glu Leu Cys Gln Val Ile Met Thr Asp Tyr Asn Met Gln Asn 
705                 710                 715                 720 


Gln Glu Asn Lys Ser Ile Lys Ser Lys Glu Arg Gln Asp Lys Asp Arg 
                725                 730                 735     


Lys Asn Gly Ile Asp Asn Ser Tyr Lys His Phe Pro Leu Leu Leu His 
            740                 745                 750         


His Leu Ile Lys Val Ser Phe Leu Lys Phe Ile Lys Thr Asp Glu Lys 
        755                 760                 765             


Leu Ala Phe Ile Arg Glu Pro Arg Ile Thr Glu Tyr Asp Lys Thr Leu 
    770                 775                 780                 


Glu Gln Phe Glu Ala Gln Ile Gln Thr Val Asp Ile Tyr Asn Ser Leu 
785                 790                 795                 800 


Lys Met Met Val Ala Glu Asn Lys Ser Leu Leu Asp Trp Tyr Thr Leu 
                805                 810                 815     


Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asp Ile 
            820                 825                 830         


Lys Asn Tyr Ile Gln Tyr Leu Ser Asn Ile Asp Lys Arg Ala Gly Ser 
        835                 840                 845             


Val Lys Asn Asn Lys Cys Ala Ser Thr Glu Val Lys Ile Arg Gln Tyr 
    850                 855                 860                 


Ser Glu Ile Val Arg Ile Leu Asp Phe Ser Leu Gln Tyr Ile Gly Arg 
865                 870                 875                 880 


Val Ser Asn Asp Val Thr Asp Tyr Phe Val Asp Glu Asp Glu Tyr Ala 
                885                 890                 895     


Ala Phe Leu Ser Lys Tyr Val Glu Phe Ser Gly Asn Asp Thr Val Ser 
            900                 905                 910         


Met Lys Ala Phe Cys Gln Ser Arg Thr Ala Asn Gly Lys His Thr Ile 
        915                 920                 925             


Gly Leu Tyr Cys Asp Gly Ala Asn Pro Ile Met Asn Arg Asn Ile Ala 
    930                 935                 940                 


Tyr Ala Lys Met Tyr Gly Asn Asp Glu Ile Leu Ser Tyr Ile Tyr Asn 
945                 950                 955                 960 


Lys Val Thr Lys Lys Asp Ile Glu Lys Tyr Tyr Val Ser Gln Asp Asn 
                965                 970                 975     


Leu Glu Lys Val Phe Ala Asp Gly Lys Cys Gln Asp Val Gln Gln Gln 
            980                 985                 990         


Asn Ala Leu Cys Asp Phe Gln Lys  Met Lys Asn His Ile  Glu Leu Thr 
        995                 1000                 1005             


Glu Val  Ser Ile Tyr Thr Asp  Ile Leu Asn Asp Phe  Met Ala Gln 
    1010                 1015                 1020             


Phe Ile  Ser Trp Ala Tyr Leu  Arg Glu Arg Asp Leu  Met Tyr Phe 
    1025                 1030                 1035             


Gln Leu  Gly Leu Asn Tyr Ile  Arg Met Phe Tyr Gly  Thr Tyr Glu 
    1040                 1045                 1050             


Leu Glu  Glu Lys Tyr Asn Lys  Leu His Gly Glu Asn  Ile Asn Ile 
    1055                 1060                 1065             


Glu Lys  Gly Ala Leu Leu Tyr  Gln Ile Val Ala Met  Tyr Ser His 
    1070                 1075                 1080             


Glu Leu  Pro Ile Tyr Lys Val  Asp Glu Ser Asp Ile  Ala Ile Leu 
    1085                 1090                 1095             


Ala Glu  Lys Gln Gly Ser Ser  Gly Ala Ser Ile Lys  Ser Phe Val 
    1100                 1105                 1110             


Thr Glu  Tyr Cys Lys Glu Glu  Met Lys Lys Ala Tyr  Thr Tyr Glu 
    1115                 1120                 1125             


Asn Gly  Leu Glu Phe Phe Glu  Asp Val Asn Gln His  Asp Asn Leu 
    1130                 1135                 1140             


Ser Lys  Leu Arg Asn Asp Phe  Ala His Met Arg Tyr  Met Ser Ala 
    1145                 1150                 1155             


Arg Asp  Lys Ser Ile Met Asp  Ile Val Ser Glu Ile  Tyr Asn Gly 
    1160                 1165                 1170             


Phe Phe  Ile Tyr Asp Thr Lys  Leu Lys Lys Ser Val  Ser Phe Ile 
    1175                 1180                 1185             


Phe Lys  Asn Ile Leu Met Arg  Tyr Ala Val Asp Val  Asn Ile Glu 
    1190                 1195                 1200             


Phe Cys  His Lys Gly Asp Asn  Glu Asp Thr Asn Asn  Leu Ile Arg 
    1205                 1210                 1215             


Ile Lys  Asp Glu Val Gly Leu  Tyr Ser Asp Lys Tyr  Thr Tyr Lys 
    1220                 1225                 1230             


Val Glu  Asp Asn Asp Thr Val  Asp Ile Glu Val Arg  Asn Ser Glu 
    1235                 1240                 1245             


Phe Leu  Glu Gln Leu Lys Lys  Leu Leu Glu Tyr Lys  Lys Glu Ser 
    1250                 1255                 1260             


Lys Gly  Ser Glu Leu 
    1265             


<210>  258
<211>  1188
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  258

Met Arg Ile Val Lys Pro Tyr Gly Arg Ser His Val Glu Pro Ala Ala 
1               5                   10                  15      


Thr Gly Ser Thr Arg Arg Val Leu Arg Leu Arg Pro Pro Asn Asp Lys 
            20                  25                  30          


Asp Ala Lys Asp Ile Glu Ala Phe Ala Arg Ser His Glu Glu Leu Val 
        35                  40                  45              


Ile Ala Gln Trp Ile Ser Ala Leu Asp Lys Ile Ala Thr Lys Pro Ser 
    50                  55                  60                  


Gly Lys Asp Gly Ala Ser Asp Ala Gln Arg Ala Phe Arg Glu Arg Leu 
65                  70                  75                  80  


Gly Asn Ala Ala Trp Thr Leu Leu Glu Thr Lys Gly Leu Leu Pro Gly 
                85                  90                  95      


Leu Val Thr Arg Arg Glu His Leu Thr Met Leu Trp Arg Ala Lys Val 
            100                 105                 110         


His Pro Tyr Gly Ser Thr Pro Tyr Arg Pro Lys Arg Gly Lys Pro Ala 
        115                 120                 125             


Pro Ser Leu Lys Gly Arg Arg Tyr Glu Arg Phe Ala Gly Gln Leu Glu 
    130                 135                 140                 


Val Asp Lys Val Asp Ala Ala Ala Ile Ala Ala Ser Ile His Ala His 
145                 150                 155                 160 


Leu His Gly Thr Ala Val Pro Ala Val Arg Pro Gly Leu Ile Ala Thr 
                165                 170                 175     


Arg Ala Arg Ser Ile Ala Glu Asn Val Leu Arg Pro Pro Gln Arg Leu 
            180                 185                 190         


Pro Asn Glu Glu Arg Ser Trp Ser Asp Asp Asp Glu Arg Ala Tyr Ala 
        195                 200                 205             


Ala Ala Gly Asp Val Ala Arg Glu Ile Gln Glu Leu Ala Ile Ala Ile 
    210                 215                 220                 


Glu Glu Asp Ala Ser Gln Arg Arg Arg Gly Lys Pro Leu Thr Arg Ser 
225                 230                 235                 240 


Pro Phe Ala Leu Arg Asp Ala Ala Pro Ala Leu Arg Gly Gln Tyr Gly 
                245                 250                 255     


Arg Leu Leu Val Asp Ala Ser Gly Asp Ala Leu Pro Ile Ala Gln Ala 
            260                 265                 270         


Arg Ala Ala Phe Pro Gly Leu Phe Gly Leu His Met Ala Val Arg Asp 
        275                 280                 285             


Cys Tyr Ser Arg Ile Leu Lys Asp His Arg Lys Ser Ser Val Val Arg 
    290                 295                 300                 


Ile Leu Pro Arg Asp Met Glu Glu Leu Leu Arg Leu Val Gly Ala Lys 
305                 310                 315                 320 


Leu Thr Asn Arg Asp Leu Asn Ala Met Val Arg Leu Gly Lys Val Ile 
                325                 330                 335     


His Tyr Gln Ser Ser Leu Gly Val Glu Asp Ser Pro Glu Asn Val Ala 
            340                 345                 350         


Ala Asn Trp Pro Ala Asp Val Ser Gly Ser Glu Phe Trp Thr Ser Ala 
        355                 360                 365             


Gly Gln Ala Gln Ile Lys Arg Asn Glu Ala Phe Val Arg Val Trp Arg 
    370                 375                 380                 


His Val Leu Ala Leu Ala Gln Arg Thr Leu Thr Asp Trp Ile Asp Pro 
385                 390                 395                 400 


Gln Gly Lys Thr Gln Gly Asp Ile Leu Leu Ala Asn Pro Pro Phe Asn 
                405                 410                 415     


Arg Asp Ala Tyr Asn Arg Lys Ser Asp Leu Leu Phe Gly Lys Arg Ala 
            420                 425                 430         


Ser Leu Phe Lys Gly Val Glu Thr Phe Glu Asn Val Val Leu Thr Leu 
        435                 440                 445             


Ala Arg Arg Glu Thr Ala Ala Leu Arg His Gly Ser Phe His Phe Lys 
    450                 455                 460                 


Gly Leu Gly Gly Phe Thr Lys Val Leu Ala Glu Val Pro Lys Thr Asp 
465                 470                 475                 480 


Ala Ser Val Leu Ala Ala Val Arg Thr Leu Trp Glu Asp Asp Leu Ser 
                485                 490                 495     


Glu Arg Ala Gln Arg Leu Arg Gln Thr Leu Arg Gly Ala His Val Glu 
            500                 505                 510         


Tyr Phe Leu Asp Glu Ala Gln Gly Arg Arg Leu Leu Ser Ala Val Leu 
        515                 520                 525             


Ala Asp Ser Gly Pro Ala Thr Leu Pro Leu Pro Arg Phe Arg Arg Ile 
    530                 535                 540                 


Leu Gln Arg Ala His Asn Ala Trp Ala Lys Glu Thr Asp Gly Pro Gly 
545                 550                 555                 560 


Leu Pro Glu Pro Ala Asn Arg Met Asp Ile Lys Thr Tyr Pro Ala Leu 
                565                 570                 575     


His Cys Arg Tyr Val Ala Leu Lys His Val Tyr Glu Arg Pro Phe Arg 
            580                 585                 590         


His Trp Leu Glu Gln Arg Asp Ala Ala Ser Leu Asn Arg His Ile Asp 
        595                 600                 605             


Arg Ala Val Asp Arg Gly Thr Lys Ala Ala Arg Asp Leu Asn Ala Gly 
    610                 615                 620                 


Asp Asp Glu Asp Arg Arg Arg Ile Ile Val Ala Arg Ala Ala Ser Leu 
625                 630                 635                 640 


Gly Arg Leu Ala Glu Asp Asp Asn Val Gln Asp Phe Phe Phe Glu Leu 
                645                 650                 655     


Ser Ala Glu Thr Ala Gly Glu Met Arg Val Gln Arg Gly Tyr Ala Ser 
            660                 665                 670         


Asp Ala Glu Ala Ala Arg Glu Gln Ala Gly Tyr Ile Glu Asp Leu Lys 
        675                 680                 685             


Cys Asp Val Leu Ala Leu Thr Phe Ala Asp Tyr Leu Lys Ala Ala Gly 
    690                 695                 700                 


Leu Asp Phe Ile Arg Ile Leu Ala Pro Glu Thr Pro Arg Pro Asp Asn 
705                 710                 715                 720 


Ala Ala Tyr Asn Leu Asp Ala Ile Glu Ala Pro Glu Ile Asp Thr Pro 
                725                 730                 735     


Gly Glu Asp Trp Gln Arg Val Leu Tyr Phe Ile Leu His Leu Val Pro 
            740                 745                 750         


Val Glu Asp Val Gly Arg Leu Leu His Gln Thr Arg Lys Trp Glu Ile 
        755                 760                 765             


Leu Ala Gly Asp Glu Thr Leu Ser Pro Ser Val Arg Asp Arg Leu Arg 
    770                 775                 780                 


Gly Ile Gln Leu Ala Leu Glu Leu Tyr Leu Asp Met His Asp Ala Lys 
785                 790                 795                 800 


Phe Glu Gly Gly Ala Ala Leu Val Gly Thr Gly Ala Phe Lys Asp Leu 
                805                 810                 815     


Phe Glu Thr Ala Arg Ile Phe Asp Asp Ile Phe Pro Ser Gln Pro Gly 
            820                 825                 830         


Ser Ala Gln Thr Ala Asp Asp Glu Arg Arg Val Pro Lys Arg Gly Leu 
        835                 840                 845             


Cys Glu Ile Met Arg Phe Gly His Arg Pro Ala Leu Gln Pro Ile Phe 
    850                 855                 860                 


Ser Arg Tyr Arg Val Thr Glu Arg Glu Val Glu Glu Val Arg Ala Met 
865                 870                 875                 880 


Glu Trp Pro Val Asp Gly Thr Ser Glu Ile Ala Arg Leu Gln Asp Arg 
                885                 890                 895     


Arg Glu Arg Leu His Lys Gly Trp Thr Glu Asn Lys Ser Gly Leu Ser 
            900                 905                 910         


Gly Asp Asp Leu Arg Ala Tyr Val Ala Ala Leu Arg Glu Val Ala Ala 
        915                 920                 925             


His Arg His Leu Ala Ala His Val Thr Leu Thr Asn His Val Arg Leu 
    930                 935                 940                 


His Arg Leu Leu Met Ala Val Leu Gly Arg Leu Val Asp Tyr Ser Gly 
945                 950                 955                 960 


Leu Trp Glu Arg Asp Leu Tyr Phe Val Thr Leu Ala Leu Ile His Arg 
                965                 970                 975     


Ala Gly Arg Arg Pro Ala Asp Val Leu Pro Ala Asp Gly Leu Arg Phe 
            980                 985                 990         


Leu Ala Asn Gly Gln Ile Val Glu  Ala Val Arg Arg Leu  Glu Pro Asp 
        995                 1000                 1005             


Leu Gln  Ser Arg Leu Leu Asp  Cys Leu Gly Asp Ile  Asp Lys Asn 
    1010                 1015                 1020             


Gly Lys  Val Arg Ile Arg Asn  Arg Phe Ala His Phe  Asn Met Leu 
    1025                 1030                 1035             


Gln Pro  Gly Asn Leu Pro Val  Asp Leu Thr Arg Cys  Val Asn Asp 
    1040                 1045                 1050             


Ala Arg  Glu Leu Met Ala Tyr  Asp Arg Lys Leu Arg  Asn Ala Val 
    1055                 1060                 1065             


Thr Gln  Ser Val Lys Glu Leu  Leu Ala Arg Glu Gly  Leu Met Leu 
    1070                 1075                 1080             


Gly Trp  Ala Met Gly Ala Asp  His Arg Leu Ser Ala  Ala Thr Leu 
    1085                 1090                 1095             


Ala Thr  Arg Gln Ala Gln His  Leu Gly Lys Thr Arg  Arg Gly Glu 
    1100                 1105                 1110             


Lys Gly  Trp His Glu Arg Lys  Leu Arg Pro Ile Pro  Ile Leu Glu 
    1115                 1120                 1125             


Asp Leu  His Gly Arg Arg Phe  Val Asp Met Ala Ala  Ala Leu Phe 
    1130                 1135                 1140             


Gly Gly  Thr Arg Leu Glu Pro  Glu Arg Ser Leu Leu  Asp His Pro 
    1145                 1150                 1155             


Leu Asp  Arg Ile Glu Trp Asn  Pro Thr Pro Lys Asn  Arg Tyr Gly 
    1160                 1165                 1170             


Ser Arg  Pro Thr Ser Gly Gln  Gly Arg Arg Asn Val  Val Pro Arg 
    1175                 1180                 1185             


<210>  259
<211>  1217
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  259

Met Arg Ile Ile Lys Pro Tyr Gly Arg Ser His Val Glu Gly Val Ala 
1               5                   10                  15      


Thr Glu Gln Pro Arg Arg Lys Leu Arg Leu Asn Thr Arg Pro Asp Ile 
            20                  25                  30          


Ser Arg Asp Ile Pro Gly Phe Ala Gln Ser His Asp Ala Leu Ile Ile 
        35                  40                  45              


Ala Gln Trp Ile Ser Ala Ile Asp Lys Ile Ala Thr Lys Pro Lys Pro 
    50                  55                  60                  


Asp Gln Lys Pro Thr Gln Arg Gln Met Asn Leu Arg Thr Thr Leu Gly 
65                  70                  75                  80  


Asp Ala Ala Trp Gln His Leu Met Ala Lys Asn Leu Leu Pro Ala Ala 
                85                  90                  95      


Lys Asp Pro Ala Ile Arg Glu Lys Leu His Leu Ile Trp Gln Ser Lys 
            100                 105                 110         


Ile Ala Pro Trp Gly Ala Ser Arg Pro Gln Glu Glu Lys Arg Gly Lys 
        115                 120                 125             


Pro Thr Pro Lys Gly Gly Trp Tyr Glu Arg Phe Cys Gly Ala Leu Ser 
    130                 135                 140                 


Pro Glu Ala Ile Thr Gln Asn Val Ala Arg Gln Ile Ala Lys Asp Ile 
145                 150                 155                 160 


Tyr Asp His Leu Tyr Val Ala Ala Lys Arg Lys Gly Arg Glu Pro Val 
                165                 170                 175     


Lys Gln Gly Glu Ser Ser Asn Lys Pro Gly Lys Phe Lys Pro Asp Arg 
            180                 185                 190         


Lys Leu Ser Leu Ile Glu Glu Arg Ala Glu Ser Ile Ala Lys Asn Ala 
        195                 200                 205             


Leu Arg Pro Gly Thr His Ala Pro Cys Pro Trp Gly Gln Asp Asp Gln 
    210                 215                 220                 


Ala Ile Tyr Glu Gln Ala Gly Asp Val Ala Thr Lys Ile Tyr Asp Asp 
225                 230                 235                 240 


Ala Arg Asp Tyr Leu Glu Asp Lys Lys Arg Arg Ser Gly Asn Arg Asn 
                245                 250                 255     


Thr Ser Ser Val Gln Tyr Leu Pro Arg Asp Leu Ala Val Lys Ile Leu 
            260                 265                 270         


Tyr Ala Gln Tyr Gly Arg Val Phe Gly Pro Asp Thr Thr Ile Lys Ala 
        275                 280                 285             


Ala Leu Asp Glu Gln Gln Ser Leu Phe Ala Leu His Thr Ala Ile Lys 
    290                 295                 300                 


Asp Cys Tyr His Arg Leu Val Asn Asp Ala Arg Lys Arg His Ile Leu 
305                 310                 315                 320 


Arg Ile Leu Pro Arg Asn Met Ala Ala Leu Phe Arg Leu Val Arg Ala 
                325                 330                 335     


Gln Tyr Asp Asn Arg Asp Ile Asn Ala Leu Ile Arg Leu Gly Lys Val 
            340                 345                 350         


Ile His Tyr His Ala Gly Glu Gln Gly Lys Asp Glu His His Gly Ile 
        355                 360                 365             


Arg Asp Tyr Trp Pro Ser Gln Gln Asp Ile Gln Asn Ser Arg Phe Trp 
    370                 375                 380                 


Gly Ser Asp Gly Gln Ala Asp Ile Lys Arg His Glu Ala Phe Ser Arg 
385                 390                 395                 400 


Ile Trp Arg His Ile Ile Ala Leu Ala Ser Arg Thr Leu His Asp Trp 
                405                 410                 415     


Ala Asp Pro Asp Ser Gln Lys Phe Thr Gly Asp Asp Asp Asp Ile Leu 
            420                 425                 430         


Met Arg Ala Gly Ala Ile Glu Ser Asn Val Trp Asp Ala Gly Arg Tyr 
        435                 440                 445             


Glu Arg Lys Cys Asp Val Leu Phe Gly Ala Gln Ala Ser Leu Phe Cys 
    450                 455                 460                 


Gly Ala Glu Asp Phe Glu Lys Ala Thr Leu Lys Gln Ala Ile Thr Gly 
465                 470                 475                 480 


Thr Gly Asn Leu Arg Asn Ala Thr Phe His Phe Lys Gly Lys Ala Arg 
                485                 490                 495     


Phe Glu Asn Glu Leu Gln Arg Leu Ala Asp Asp Val Pro Val Asp Val 
            500                 505                 510         


Gln Ser Ala Ile Ala Ala Leu Trp Gln Lys Asp Ala Glu Gly Arg Thr 
        515                 520                 525             


Arg Gln Ile Ala Glu Thr Leu Gln Ala Val Leu Ala Gly His Phe Leu 
    530                 535                 540                 


Ser Glu Arg Gln Asn Arg His Ile Leu Ala Thr Leu Met Ala Ala Met 
545                 550                 555                 560 


Ala Gln Pro Gly Asp Val Pro Leu Pro Arg Leu Arg Arg Val Leu Ala 
                565                 570                 575     


Arg His Asp Ser Ile Cys Gln Arg Gly Arg Ile Leu Pro Leu Pro Pro 
            580                 585                 590         


Cys Pro Asp Arg Ala Lys Leu Glu Glu Ser Pro Ala Leu Thr Cys Gln 
        595                 600                 605             


Tyr Thr Val Leu Lys Met Leu Tyr Asp Gly Pro Phe Arg Ala Trp Leu 
    610                 615                 620                 


Ala Gln Gln Asn Ser Thr Ile Leu Asn His Tyr Ile Asp Ser Thr Ile 
625                 630                 635                 640 


Ala Arg Thr Asn Lys Ala Ala Gln Asp Met Asn Gly Arg Lys Leu Ala 
                645                 650                 655     


Pro Ala Glu Lys Asp Leu Ile Thr Ala Arg Ala Ala Asp Ile Pro Arg 
            660                 665                 670         


Leu Ser Val Asp Glu Lys Met Val Asp Phe Leu Gly Arg Leu Thr Ala 
        675                 680                 685             


Ala Thr Ala Thr Glu Met Arg Val Gln Arg Gly Tyr Gln Ser Asp Gly 
    690                 695                 700                 


Glu Lys Ala Gln Lys Gln Ala Gly Tyr Ile Gly Glu Phe Glu Cys Asp 
705                 710                 715                 720 


Val Ile Ala Arg Ala Phe Ser Asp Phe Leu Gly Gln Ser Gly Phe Asp 
                725                 730                 735     


Phe Val Leu Lys Leu Lys Ala Asp Thr Pro Lys Pro Asp Ala Ala Gln 
            740                 745                 750         


Cys Asp Val Ala Ala Leu Ile Ala Pro Gly Asp Val Pro Ala Leu Thr 
        755                 760                 765             


Pro Gln Ala Trp Gln Gln Val Leu Tyr Phe Ile Leu His Leu Val Pro 
    770                 775                 780                 


Val Asp Asp Ala Ser Arg Leu Leu His Gln Thr Arg Lys Trp Gln Ala 
785                 790                 795                 800 


Leu Glu Lys Lys Gly Lys Asp Lys Glu Val Lys Lys Glu Lys Asp Lys 
                805                 810                 815     


Glu Val Lys Lys Glu Asp Glu Lys Pro Asp Ile Ala Asp Leu Gln Ser 
            820                 825                 830         


Val Leu Met Leu Tyr Leu Asp Met His Asp Ala Lys Phe Thr Gly Gly 
        835                 840                 845             


Ala Ala Leu His Gly Ile Glu Lys Phe Ala Glu Phe Phe Val Glu Lys 
    850                 855                 860                 


Ala Asp Phe Arg Ala Val Phe Pro Pro Gln Ser Leu Gln Asp Gln Asp 
865                 870                 875                 880 


Arg Ser Ile Pro Arg Arg Gly Leu Arg Glu Ile Val Arg Phe Gly His 
                885                 890                 895     


Leu Pro Leu Leu Gln His Met Ser Gly Thr Val Lys Ile Thr His Asp 
            900                 905                 910         


Asn Val Val Ala Trp Gln Thr Ala Arg Thr Pro Asp Ala Thr Gly Thr 
        915                 920                 925             


Ser Pro Ile Ala Arg Arg Gln Lys Gln Arg Glu Glu Leu His Ala Leu 
    930                 935                 940                 


Ala Val Glu Arg Pro Ala Arg Phe Arg Asn Ala Asp Leu His Asn Tyr 
945                 950                 955                 960 


Met His Ala Leu Val Asp Val Ile Lys His Arg Gln Leu Ser Ala Gln 
                965                 970                 975     


Val Thr Leu Ser Asp Gln Val Arg Leu His Arg Leu Met Met Gly Val 
            980                 985                 990         


Leu Gly Arg Leu Val Asp Tyr Ala  Gly Leu Trp Glu Arg  Asp Leu Tyr 
        995                 1000                 1005             


Phe Val  Leu Leu Ala Leu Leu  Tyr His His Gly Val  Thr Pro Asp 
    1010                 1015                 1020             


Asp Val  Leu Lys Gly Gln Gly  Lys Arg Lys Leu Ala  Asp Gly Gln 
    1025                 1030                 1035             


Val Val  Glu Ala Leu Lys Pro  Lys Asn Arg Lys Ala  Ala Ala Pro 
    1040                 1045                 1050             


Val Gly  Val Phe Asp Asp Leu  Asp His Tyr Gly Ile  Tyr Gln Asp 
    1055                 1060                 1065             


Asp Arg  Gln Ser Ile Arg Asn  Gly Leu Ser His Phe  Asn Met Leu 
    1070                 1075                 1080             


Arg Gly  Gly Thr Ala Pro Asp  Leu Ser His Trp Val  Asn Gln Thr 
    1085                 1090                 1095             


Arg Arg  Leu Val Ala His Asp  Arg Lys Leu Lys Asn  Ala Val Ala 
    1100                 1105                 1110             


Lys Ser  Val Ile Glu Met Leu  Ala Arg Glu Gly Phe  Asp Leu Asp 
    1115                 1120                 1125             


Trp Thr  Ile Glu Pro Asp Ser  Gly Lys His Ile Leu  Arg His Gly 
    1130                 1135                 1140             


Lys Ile  Arg Thr Arg Gln Ala  Gln His Phe Gln Lys  Ser Arg Ile 
    1145                 1150                 1155             


Arg Ile  Glu Lys Lys Ser Ala  Lys Pro Asp Lys Asn  Asp Thr Val 
    1160                 1165                 1170             


Lys Ile  Arg Glu Asn Leu His  Gly Asp Ala Met Val  Glu Arg Val 
    1175                 1180                 1185             


Ala Arg  Leu Phe Ala Ala Arg  Ala Gln Lys Tyr Arg  Asp Ile Thr 
    1190                 1195                 1200             


Thr Glu  Lys Arg Leu Asp His  Leu Phe Leu Lys Pro  Lys Gly 
    1205                 1210                 1215         


<210>  260
<211>  1227
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  260

Met Leu Ile Ile Lys Pro Tyr Gly Arg Ser His Val Asp Thr Ser Pro 
1               5                   10                  15      


Asn Gly Arg Arg Arg Thr Leu His Leu Asn Thr Thr Pro Thr Asn Ser 
            20                  25                  30          


Lys Asp Ile Ala Glu Phe Ala Lys Ser Asp Pro Arg Leu Val Ile Ala 
        35                  40                  45              


Gln Trp Ile Ser Ala Ile Asp Lys Ile Ala Thr Lys Pro Lys Ala Asn 
    50                  55                  60                  


Thr Arg Pro Thr Ala Ala Gln Arg Ala Phe Arg Lys Lys Leu Gly Glu 
65                  70                  75                  80  


Ala Cys Trp Gln Tyr Ile Glu Thr His Gln Leu Val Pro Gly Leu Asp 
                85                  90                  95      


Asp Lys Glu Ile Asn Pro Lys Leu His Thr Leu Trp Trp Ser Lys Ile 
            100                 105                 110         


Glu Pro Tyr Asp Lys Lys Asp Phe Ser Pro Lys Arg Lys Pro Pro Ala 
        115                 120                 125             


Val Gly Gly Arg Trp Tyr Lys Arg Phe Ala Gly Glu Ala Lys Pro Glu 
    130                 135                 140                 


His Val Asp Gly Ala Ser Ile Ala Glu Lys Leu His Glu His Leu Tyr 
145                 150                 155                 160 


Val Ser Glu Tyr Arg Ile Asp Ala Thr Arg Pro Asn Lys Arg Lys Gly 
                165                 170                 175     


Arg Ile Asn Ala Arg Ala Glu Ser Ile Glu Lys Asn Val Leu Lys Pro 
            180                 185                 190         


Pro Gln Lys Ser Val Glu Gly Trp Asn Ala Lys Asp Glu Ala Asp Tyr 
        195                 200                 205             


Leu Arg Ala Gly Asp Ile Ala Gln Ala Ile Tyr Ala Ala Ala Glu Thr 
    210                 215                 220                 


Ala His Asn Thr Lys Asp His Asn Gly Arg Ala Arg Pro Arg Arg Leu 
225                 230                 235                 240 


Thr Leu Ser Glu Ala Ser Val Glu Leu Phe Lys Gln Tyr Gly His Leu 
                245                 250                 255     


Phe Arg Asp Lys Ser Gly Thr Pro Leu Ser Ile Glu Glu Ala Lys Ala 
            260                 265                 270         


Gln His Thr His Leu Phe Asp Leu His Met Ala Val Lys Asp Phe Tyr 
        275                 280                 285             


Lys Arg Arg Leu Lys His Ser Lys Arg Gln Asn Ile Leu Thr Ser Leu 
    290                 295                 300                 


Pro Lys Asp Ser Ala Ala Leu Phe Thr Leu Leu Lys Val Thr Lys Gln 
305                 310                 315                 320 


Asn Gln Asp Leu Ala Gly Leu Val Arg Leu Gly Lys Val Ile His Tyr 
                325                 330                 335     


Glu Met Ser His Gln Ala Trp Glu Ser Gly Lys Pro Ala Glu Thr Glu 
            340                 345                 350         


Glu Ala Glu Trp Asn Arg Leu Lys Gly Leu Met Thr Ser Trp Ser Arg 
        355                 360                 365             


Ala Asp Arg Phe Ala Gln Tyr Trp Pro Lys Asn Ile Glu Glu Ser Ala 
    370                 375                 380                 


Phe Trp Thr Ser Lys Gly Gln Glu Glu Ile Gln Arg His Glu Ala Phe 
385                 390                 395                 400 


Val Arg Ile Trp Arg His Ile Met Thr Leu Ala Asn Arg Thr Leu Thr 
                405                 410                 415     


Asp Trp Ala Tyr Pro Asp Thr His Ile Ser His Asp Ile Phe Glu Gly 
            420                 425                 430         


Lys Lys Ile Asn His Ala Leu Lys Gln Val Ser Ala Glu Gln His Lys 
        435                 440                 445             


Arg Lys Leu Asp Leu Leu Phe Gly Lys His Gly Asp Leu Leu Ala Ser 
    450                 455                 460                 


Asn Asn Leu Ala Pro Lys Ile Leu Glu Thr Ala Ile Lys Arg Met Ala 
465                 470                 475                 480 


Tyr Leu Arg Asn Asn Ser Phe His Phe Thr Asp Lys Arg Ile Phe Ala 
                485                 490                 495     


Thr Ala Leu Thr Arg Leu Thr Glu Asn Val Pro Asn Glu Val Lys Pro 
            500                 505                 510         


Ser Leu Ser Ala Leu Trp Gln Ala Asp Asn Ala Asp Arg Thr Ala Ala 
        515                 520                 525             


Ile Gly Arg Ala Met Gln Ala Val His Ala Thr Ala Tyr Phe Asp Glu 
    530                 535                 540                 


Thr Gln Asn Arg Asn Ile Phe Thr Ala Val Lys Gly Ala Pro Pro Ser 
545                 550                 555                 560 


Leu Leu Ala Leu Pro Arg Phe Arg Arg Ile Ile Val Arg Ala Glu Asn 
                565                 570                 575     


Ala Trp Gly His Glu Lys Asp Arg Pro Gly Leu Pro Glu Pro Ala Asn 
            580                 585                 590         


Arg Gln Ala Leu Glu Asp Pro Ala Arg Leu Cys Gln Tyr Ala Thr Thr 
        595                 600                 605             


Lys Gln Leu Tyr Asp Gly Pro Phe Arg His Trp Leu Asp Thr Arg Ser 
    610                 615                 620                 


Ala Gln Thr Val Asn Leu Tyr Ile Gly Arg Ala Val Asp Arg Ala Thr 
625                 630                 635                 640 


Lys Ala Ala Gln Asn Met Asn Gly Lys Gln Lys Thr Asp Glu Glu Lys 
                645                 650                 655     


Ala Leu Ile Ala Ser Arg Ala Thr His Leu Pro Arg Leu Asp Glu Thr 
            660                 665                 670         


Lys Gly Gly Glu Thr Ile Arg Asp Phe Phe Phe Arg Leu Ala Ala Ser 
        675                 680                 685             


Thr Ala Thr Glu Met Arg Val Gln Lys Gly Tyr Glu Ser Asp Gly Gly 
    690                 695                 700                 


Asn Ala Gln Lys Gln Ala Glu Phe Ile Glu Asp Leu Lys Cys Asp Val 
705                 710                 715                 720 


Val Ala Leu Ala Leu Ala Asp Tyr Leu Ala Lys His His Phe Thr Phe 
                725                 730                 735     


Ile Leu Ser Leu Lys Pro Glu Thr Pro Leu Pro Thr Glu Glu Ile Asn 
            740                 745                 750         


Leu Glu Ser Phe Ala Thr Ser Asp Ala Lys Gln Arg Asn Thr Ser Glu 
        755                 760                 765             


Arg Ala Ser Asp Trp Gln Ala Val Leu Tyr Phe Leu Leu His Leu Ile 
    770                 775                 780                 


Pro Val Asp Asp Ala Ser Arg Leu Leu His Gln Ile Arg Lys Trp Met 
785                 790                 795                 800 


Val Leu Glu Ala Lys Ser Lys Ala Glu Gly Thr Arg Pro Ile Gln Thr 
                805                 810                 815     


Pro Asp Thr Thr Ile Leu Lys Thr Val Glu Thr Leu Glu Leu Tyr Leu 
            820                 825                 830         


Ala Met His Asp Thr Lys Phe Glu Gly Gly Met Glu Leu Thr Gly Thr 
        835                 840                 845             


Asp Gly Phe Lys Asp Phe Tyr Glu Ser Glu Thr Gly Phe Lys Lys Leu 
    850                 855                 860                 


Phe Ser Asn Pro Glu Asn Val Glu Asp His Thr Val Pro Arg Arg Gly 
865                 870                 875                 880 


Leu Arg Glu Val Met Arg Phe Gly His Leu Pro Leu Leu Arg Gln Val 
                885                 890                 895     


Cys Gly Gln Gln Thr Ile Ser Asp Ser Gln Ile Thr Glu Trp Glu Thr 
            900                 905                 910         


Ala Asn Asn Ala Ser Pro Gly Gly His Ser Pro Ile Ala Ala Gln Gln 
        915                 920                 925             


His Lys Arg Glu Ala Leu His Glu Glu Tyr Val Lys Ser Thr Asn Thr 
    930                 935                 940                 


Phe Ser Ile Ala Lys Ile Lys Asp Tyr Ala Thr Ala Leu Ser Phe Val 
945                 950                 955                 960 


Ser Arg His Arg Thr Leu Ala Ala His Val Thr Leu Ser Asn His Val 
                965                 970                 975     


Arg Ala His Arg Ile Met Met Ala Val Leu Ala Arg Leu Ala Asp Tyr 
            980                 985                 990         


Ala Gly Leu Trp Glu Arg Asp Leu  Tyr Phe Val Thr Leu  Ala Val Cys 
        995                 1000                 1005             


Tyr Gln  Arg Gly Leu Arg Pro  Asp Val Val Phe Lys  Asn Asp Gly 
    1010                 1015                 1020             


Leu Ser  Glu Leu Ala Lys Arg  Gln Pro Ile Lys Ala  Gln Ser Lys 
    1025                 1030                 1035             


Lys Leu  Gly Thr Ser Asp Ser  Asn Ala Val Gln Gln  Glu Ile Val 
    1040                 1045                 1050             


Arg Tyr  Phe Gly Asn Val His  Val Glu Gly Asn Asp  Asp Val Lys 
    1055                 1060                 1065             


Thr Arg  Asn Asp Leu Ala His  Phe Asn Met Leu Gln  Gly Gly Thr 
    1070                 1075                 1080             


Leu Asn  Leu Thr Glu Trp Val  Asn Gln Thr Arg Gln  Leu Met Arg 
    1085                 1090                 1095             


His Asp  Arg Lys Leu Lys Asn  Ala Val Thr Gln Ser  Val Arg Glu 
    1100                 1105                 1110             


Leu Leu  Ala Arg Glu Gly Leu  Asp Leu Thr Trp Gln  Ile Asp Ala 
    1115                 1120                 1125             


Asn Ala  His Pro His Leu Leu  His Arg Ala Thr Leu  Ala Thr Arg 
    1130                 1135                 1140             


Tyr Ala  Ile His Leu Gln Lys  Val Lys Gly Leu Gln  Pro Lys Leu 
    1145                 1150                 1155             


Leu Glu  Pro Leu His Gly Glu  Asp Phe Ile Ala Met  Ile Cys Ala 
    1160                 1165                 1170             


Leu Phe  Asn Gly Lys Ala Val  Gly Gly Ile Asp Pro  Val Lys His 
    1175                 1180                 1185             


Met Asp  Met Ala Cys Leu Asp  Leu Gln Arg Leu Cys  Leu Gln Lys 
    1190                 1195                 1200             


Asn Gln  Gly Arg Thr Gly Thr  Lys Lys Pro His Gly  Lys Gly Arg 
    1205                 1210                 1215             


Ser Arg  Met Gln Arg Arg Ser  Lys Lys 
    1220                 1225         


<210>  261
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  261

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Val Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Val 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Lys Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Met 
    690                 695                 700                 


Tyr Ile Gly Asn Asp Glu Gln Ile Asn Thr Ser Leu Ala Gly Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Lys Ile Leu Lys Tyr Thr Glu Ser Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Lys Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Leu Lys Glu Leu Lys Glu Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn Tyr Thr Met Gln Gln Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Lys Lys Asp Glu Lys Phe Asn Asp Glu Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Ile Met Lys Ser  Val Val Asn Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Lys Phe Lys  Ile Gly Ala Asp Asn  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Lys Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Glu  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  262
<211>  1287
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  262

Met Arg Ile Gly Lys Val Gln Gly Arg Thr Phe Thr Gly Phe Asp Asn 
1               5                   10                  15      


Ala Arg Gly Lys Thr Leu Arg Arg Arg Leu Leu Thr Arg Pro Asp Asn 
            20                  25                  30          


Glu Ala Arg Ser Leu Ser Glu His Leu Ala His Asp Pro Lys Ala Leu 
        35                  40                  45              


Ile Gly Gln Ala Ile Ser Arg Ile Asp Thr Ile Tyr Gln Lys Pro Lys 
    50                  55                  60                  


Thr Gly Lys Pro Thr Pro Glu Gln Phe Gly His Arg Asp Thr Leu Gly 
65                  70                  75                  80  


Trp Ala Tyr Trp Lys Leu Leu Val Ala Ser Tyr Pro Glu Val Glu Gly 
                85                  90                  95      


His Arg Asp Leu Phe Val Arg Arg Leu His Pro Tyr Gly Asp Thr Pro 
            100                 105                 110         


Pro Lys Ser His Gly Gln Lys Glu Gly Glu His Gln Lys Gly Gly Lys 
        115                 120                 125             


Pro Gln Leu Glu Gly Arg Trp His Gly Val Met Ala Gln His Gly Lys 
    130                 135                 140                 


Asn Pro Asp Gln Ile Ala Ala Arg Leu Phe Asp His Leu His Asn Ser 
145                 150                 155                 160 


Glu Leu Arg Phe Gly Gly Thr Ala Ser Gly Glu Pro Arg Thr Arg Pro 
                165                 170                 175     


Gly Lys Glu Ala Thr Pro Thr Gly Leu Ile Gly Ala Arg Ala Lys Thr 
            180                 185                 190         


Ile Glu His Ser Val Leu Pro Arg Asp Ala Lys Arg Phe Val Ala Glu 
        195                 200                 205             


Trp Arg Gly Glu Asp Gln Glu Arg Tyr Ala Gly Ala Arg Asp Ile Ala 
    210                 215                 220                 


Ala Ala Ile Ser Ala Gly Leu Asn Asp Lys Asp Gln Lys Ser Gly Ser 
225                 230                 235                 240 


Gly Arg Lys Ser Ala Val Ile Gly Lys Leu Leu Ser Asp His Leu Glu 
                245                 250                 255     


Thr Leu Thr Gly Asn Arg Lys Cys Arg Phe Asp Pro Lys Ser Thr Ala 
            260                 265                 270         


Glu Thr Leu Glu Leu Arg Asp Gly Glu Ser Val Asp Asp Arg Arg Arg 
        275                 280                 285             


Ile Leu Glu Leu His Ala Glu Val Lys Ala Thr Tyr Lys Arg Met Ala 
    290                 295                 300                 


Ala Trp Lys Pro Ala Lys Leu Pro Arg Asn Ser Asp Glu Leu Phe Arg 
305                 310                 315                 320 


Leu Val Arg Gln Gln Ala Asp Asn Arg Ile Leu Asn His Leu Val Arg 
                325                 330                 335     


Val Gly Arg Ile Ser Val Tyr Ser Glu Gln Ser Asp Ala Leu Ser Glu 
            340                 345                 350         


Ser Gln Phe Trp Thr Ser Gly Gly Gln Thr Gln Ile Lys Glu Ser Glu 
        355                 360                 365             


Val Phe Ala Arg Leu Trp Ile Gly Ala Ile Ser Arg Ala Ser Tyr Ser 
    370                 375                 380                 


Met Lys Ala Trp Leu Glu Pro Glu Gly Thr Val Phe Asn Pro Ser Ile 
385                 390                 395                 400 


Asn Asp Phe Asp Val Thr Ser Ser His Asn Thr Asn Arg Ile Leu Glu 
                405                 410                 415     


Asp Ser Gly Arg Leu Ser Asn Ala Met Ala Arg Arg Ala Ile Tyr Phe 
            420                 425                 430         


Gly Glu Thr Pro Glu Phe Asp Ala Leu Gly Glu Glu Asp Gln Arg Val 
        435                 440                 445             


Leu Val Lys Lys Cys Leu Asp Ala Leu Ser Ala Cys Arg Asn Arg Thr 
    450                 455                 460                 


Phe His His Gly Gln Arg Ala Lys Phe Leu Lys Glu Val Arg Lys Gly 
465                 470                 475                 480 


Leu Lys Glu Lys Glu Ala Asp Ser Ala Gly Pro Ala Ala Trp Glu Gly 
                485                 490                 495     


Ile Arg Glu Val Ile Gln Ala Asp Ala Arg Asn Leu Gly Ala Arg Leu 
            500                 505                 510         


Leu Gln Asp Leu Thr Gly Ala Lys Val His Ser Phe Ala Thr Asp Pro 
        515                 520                 525             


Glu Phe Arg His Leu Tyr Glu Ser Val Ala Ala Thr Leu Thr Ala Gly 
    530                 535                 540                 


Gly Glu Leu Glu Ala Ala Leu Pro Arg Leu Lys Asn Val Leu Lys Arg 
545                 550                 555                 560 


Ala Glu Gly Val Arg Cys Tyr Leu Asp Thr Pro Ser Gln Arg Arg Glu 
                565                 570                 575     


Gly Asp Glu Ser Leu Ile Ala Arg Leu Pro Val Ala Pro Val Pro Arg 
            580                 585                 590         


Glu Leu Asp Asp Ala Ala Thr Lys Ala Arg His Ser Ala Leu Leu Arg 
        595                 600                 605             


Leu Tyr Asp Gly Pro Phe Arg Pro Trp Ala Thr Glu Leu Arg Gly Glu 
    610                 615                 620                 


Arg Leu Ser Asp Tyr Ala Ala Arg Ala Lys Arg Leu Ala Thr Arg Leu 
625                 630                 635                 640 


Ala Lys Ser Thr Asn Thr Ala Ser Pro Tyr Pro Asp Ser Val Glu Gly 
                645                 650                 655     


Arg Ser Val Arg Leu Arg Asp Pro Ile Thr Ala Asp Thr Ala Pro Glu 
            660                 665                 670         


Thr Leu Lys Thr Tyr Leu Ser Ala Leu Thr Ala Glu Thr Ala Thr Glu 
        675                 680                 685             


Phe Arg Val Gln Lys Gly Tyr Glu Ser Asp Gly Glu Lys Ala Lys Glu 
    690                 695                 700                 


Gln Ala Glu Phe Ile Glu Asp Phe Arg Arg Asp Met Ile Ala Leu Ala 
705                 710                 715                 720 


Phe Gln Asp Phe Ile Arg Asp His Gly Phe Ala Trp Leu Leu Asp Ile 
                725                 730                 735     


Ala Ser Lys Ala Glu Pro Ser Asn Asp Ala Pro Asn Leu Pro Asp Pro 
            740                 745                 750         


Val Asp Thr Gly Lys Asp Thr Val Phe Glu Asp Trp Gln Ala Leu Leu 
        755                 760                 765             


Tyr Leu Phe Leu His Phe Val Pro Ala Asp Asp Val Ser Gln Leu Leu 
    770                 775                 780                 


His Gln Leu Arg Lys Trp Asp Ala Leu Gln Asp Lys Tyr Glu Leu Ala 
785                 790                 795                 800 


Glu Pro Gly Glu Thr Leu Gly Gln Thr Lys Ala Asp Thr Arg Lys Ile 
                805                 810                 815     


Val Gly Gln Phe Arg Asp Cys Leu Thr Leu Phe Leu Lys Thr Gly Asp 
            820                 825                 830         


Ala Arg Phe Asp Gly Glu Gly Val Glu Leu Pro Leu Ser Asp Phe Gln 
        835                 840                 845             


Glu Leu Phe Glu Ser Pro Ala Thr Phe Lys Glu Leu Phe Leu Ala Glu 
    850                 855                 860                 


Pro Ala Glu Asn Asp Ala Ser Glu Thr Asp Asp Gln Asp Ala Pro Gly 
865                 870                 875                 880 


Glu Lys His Arg Val Thr Arg Thr Arg Arg Gly Leu Arg Gln Ile Leu 
                885                 890                 895     


Arg Tyr Asn His Met Pro Val Leu Arg Asp Leu Phe Leu Ala His Lys 
            900                 905                 910         


Val Thr Asp Ala Glu Val Asp Gly Leu Gln Ala Leu Glu Val Asp Asp 
        915                 920                 925             


Pro Gln Thr Gly Glu Ser Gln Ile Gly Ala Ala Gln Arg Ile Arg Thr 
    930                 935                 940                 


Glu Ile His His His Thr Ser Asn Asp Lys Gln Ile Ser Glu Ala Lys 
945                 950                 955                 960 


Val Glu Glu Tyr Arg Arg Ala Leu Ser Thr Ile Glu Arg His Arg Phe 
                965                 970                 975     


Leu Val Gly Arg Val Tyr Leu Gly Asp His Ile Arg Val His Lys Leu 
            980                 985                 990         


Met Met Asp Val Met Gly Arg Leu  Val Asp Phe Ala Gly  Ala Trp Glu 
        995                 1000                 1005             


Arg Glu  Ala Ala Asp Gly Asp  Arg Lys Gly Phe Ile  Ser Arg Ala 
    1010                 1015                 1020             


Ile Ala  Leu Pro Glu Val Ala  Glu Gly Tyr Ala Ala  Asp Arg Leu 
    1025                 1030                 1035             


Lys Thr  Val Ala Arg Arg Val  Leu Asp Asp Gly Glu  Ala Arg Arg 
    1040                 1045                 1050             


Ile Arg  Asn Asp Leu Gly His  Phe Asn Asp Leu Ala  Pro Thr Ser 
    1055                 1060                 1065             


Gly Pro  Ala Asn Leu Thr Phe  Val Val Asn Arg Ala  Arg Arg Met 
    1070                 1075                 1080             


Met Arg  His Asp Arg Lys Arg  Lys Asn Ala Val Thr  Lys Ser Val 
    1085                 1090                 1095             


Ile Glu  Ile Leu Asn Arg Gln  Gly Leu Gly Ile Glu  Trp Thr Met 
    1100                 1105                 1110             


Arg Asn  His Glu Leu Cys Glu  Ala Lys Leu Trp Gln  Asn Pro Val 
    1115                 1120                 1125             


Lys His  Leu Gly Phe Ala Thr  Leu Glu Gly Arg Gly  Lys Lys Trp 
    1130                 1135                 1140             


Arg Arg  Pro Phe Glu Ala Arg  Tyr Gly Asp Ala Tyr  Met Ala Met 
    1145                 1150                 1155             


Val Ala  Gln Leu Phe Asp Gly  Thr Val Thr Ser Pro  Pro Ala Lys 
    1160                 1165                 1170             


Gly Pro  Pro Gln Ser Gly Lys  Ser Gly Gly Lys Pro  Gly Lys Gly 
    1175                 1180                 1185             


Ala Glu  Gly Gly Ala Lys Glu  Lys Ser Arg Ser Pro  Thr Arg Met 
    1190                 1195                 1200             


Glu Glu  Gly Gly Val Tyr Glu  Gly Arg Val Ala Lys  Ala Lys Ser 
    1205                 1210                 1215             


Asp Lys  Gly Phe Gly Phe Leu  Leu Val Glu Gly Ala  Gln Glu Glu 
    1220                 1225                 1230             


Ile Phe  Leu His Ile Tyr Gly  Ile Ser Gly Asn Arg  Pro Ala Arg 
    1235                 1240                 1245             


Ile Glu  Asn Gly Gln Arg Tyr  Arg Phe Thr Leu Gly  Ile Asp Arg 
    1250                 1255                 1260             


Asp Arg  Glu Arg Arg Lys Glu  Arg Ala Trp Val Ala  Arg Glu Ala 
    1265                 1270                 1275             


Val Arg  Ile Asp Glu Asn Arg  Ser Lys 
    1280                 1285         


<210>  263
<211>  1373
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  263

Met Ala Lys His Leu Arg Pro Ile Gly Glu Ser Tyr Thr Asp Phe Leu 
1               5                   10                  15      


Asp Glu Thr Glu Phe Val Arg Leu Gly Arg Gly Leu His Arg Gly His 
            20                  25                  30          


His Gly Val Gln Ile Pro Pro Thr Glu Leu Pro Ser Tyr Leu Ala Glu 
        35                  40                  45              


Tyr Arg Lys Ala Leu Met Arg Gln Val Val Ala Val Leu Asp Lys Val 
    50                  55                  60                  


Val Gly Lys Arg Arg Arg Leu Ser Gly Met His Pro Glu Ala Tyr Arg 
65                  70                  75                  80  


Asp Arg Val His Leu Ala Glu Ala Leu Trp Val Arg Leu Val Ala Arg 
                85                  90                  95      


Val Lys Glu Ile Gly Thr Pro Pro Asp Pro Ser Glu Leu Leu Asp Leu 
            100                 105                 110         


Arg Arg Met Trp Asn Ala Lys Ala His Pro Tyr Ala Glu Tyr Asp Val 
        115                 120                 125             


Val Pro Arg Ala Pro Leu Asn Asp Gly Asn Gly Gln Lys Ile Leu Glu 
    130                 135                 140                 


Cys Arg Glu Val Asp Asp Pro Lys Ile Glu Arg Ser Asp Phe Glu Gly 
145                 150                 155                 160 


Arg Trp His Gly Arg Phe Trp Gln Ser Glu Pro Gly Pro Val Asp Tyr 
                165                 170                 175     


Asn Ala Ile Ala Asp Arg Ile Phe Ala His Leu Phe Asp Gln Glu Ala 
            180                 185                 190         


Val Ile Gly Gly Gly Pro Arg Arg Glu Gly Asn Val Thr Val Pro Asp 
        195                 200                 205             


Glu Asp Ile Asn Gly Gln Pro Gly Pro Ala Thr Gly Lys Gly Leu Ile 
    210                 215                 220                 


Ile Ala Arg Gly Gln Ser Ile Val Lys Ser Ala Ser Asp Pro Arg Arg 
225                 230                 235                 240 


Ser Ser Lys Lys Val Gln Arg Thr Trp Asp Lys Ala Val Glu Arg Arg 
                245                 250                 255     


Tyr Phe Gly Asp Asp Gly Lys Gly Gly Ser Asp Ile Ala Lys Ala Ile 
            260                 265                 270         


Tyr Glu Glu Leu Gly Asp Pro Ala Thr Leu Ala Asp Pro Ile Tyr Ala 
        275                 280                 285             


Ser Trp Phe Gly Ser Arg Leu Tyr Asp His Phe Gly Ser Phe Lys Asn 
    290                 295                 300                 


Ser Leu Pro Leu Glu Leu Lys Asp Pro Phe Lys Glu Gln Ile Trp Ala 
305                 310                 315                 320 


Leu His Asn Ser Val Arg Gln Phe Tyr Gln Arg Met Ala Lys Ser Asp 
                325                 330                 335     


Arg Phe Arg Leu Ala Leu Gln Asn Ala Arg Ser Glu Val Pro Asp Arg 
            340                 345                 350         


Ser Glu Leu Leu Ala Leu Leu Pro Lys Asp His Asp His Leu Leu Leu 
        355                 360                 365             


Val Leu Gly Gly Lys Lys Lys Asn Ala Glu Met Ser Glu Leu Ile Arg 
    370                 375                 380                 


Leu Gly Lys Leu Phe Val His Ala Ser Asp Val Leu His Asp Phe Asp 
385                 390                 395                 400 


Ala Asn Asp Ala Ala Ala Leu Asp Ala Phe Lys Arg Arg Met Ser Phe 
                405                 410                 415     


Leu Ala Thr Ser Ile Gly Gln Ser Glu Ile Lys Gln Thr Glu Thr Phe 
            420                 425                 430         


Ala Arg Thr Trp Arg Gly Ala Val Gly Leu Thr Leu Arg Thr Val Lys 
        435                 440                 445             


Gly Leu Ala Asp Pro Arg Gly Ile Ile Gly Thr Pro Asp Asn Arg Asp 
    450                 455                 460                 


Leu Gly Thr Ala Gly Pro Met Lys Asp Ala Phe Asn Lys Phe Asp Gln 
465                 470                 475                 480 


Pro His Phe Gln Gln His Met Thr Ile Ile Phe Gly Asn Lys Glu Leu 
                485                 490                 495     


Gln Ala Glu Gly Asn Pro Thr Arg Ser Ser Val Phe Thr Ala Asn Gly 
            500                 505                 510         


Asp Lys Asp His Gln Ala Glu Leu Leu Trp Gly Phe Leu Cys Val Val 
        515                 520                 525             


Arg Ser Val Arg Asn Arg Thr Asn His Tyr Asn Val Arg Arg Ala Leu 
    530                 535                 540                 


Leu Arg Leu Leu Asp Glu Gly Ile Val Ser Pro Met Pro Ser Asp Pro 
545                 550                 555                 560 


Lys Lys Glu Arg Val Glu Asn Arg Asn Leu Cys Thr Val Ser Pro Thr 
                565                 570                 575     


Ala Leu Glu Ala Phe Arg Arg Leu Leu Asn Phe Asp Leu Ala Ile Gln 
            580                 585                 590         


Lys Glu Ala Val Arg Thr Ala Leu Glu Gln Ala Lys Ala Ser Glu Phe 
        595                 600                 605             


Val Glu Glu Gly Lys Leu Arg Gly Leu Val Ser Glu Leu Ala Gly Thr 
    610                 615                 620                 


Glu Asp Met Pro Ala Leu His Ile Pro Arg Phe Ser Ala Val Met Asp 
625                 630                 635                 640 


Lys Val Arg Arg Leu Ala Asp Asn Arg Asp Val Gly Leu Asp Pro Ile 
                645                 650                 655     


Leu Ser Thr Leu Gln Arg Ser Leu Pro Pro Thr Asp Lys Gln Ala Glu 
            660                 665                 670         


Ser Asp Ala Ala Arg Cys Arg Tyr Arg Leu Leu Leu Glu Leu Tyr Lys 
        675                 680                 685             


Ser Gly Phe Arg Ser Trp Phe Ser Gly Ile Gln Ser Asn Glu Glu Asn 
    690                 695                 700                 


Asn Arg Glu Ile Cys His Trp Ala Val Lys Gln Val Gly Arg Ala Lys 
705                 710                 715                 720 


Asp Ala Arg Lys Ser Glu Tyr Asp Lys Lys Thr Lys Arg His Tyr Arg 
                725                 730                 735     


Ser Pro Asn Ser Leu Ile Asp Asp Leu Gly Leu Asp Lys Phe Asp Asp 
            740                 745                 750         


Leu Thr Asp Leu Leu Glu Ala Leu Ala Ser Gln Ser Thr Arg Glu His 
        755                 760                 765             


Asp Gln Asn Leu Lys Tyr Val Pro Asp Ala Arg Val Gln Ser Gln Met 
    770                 775                 780                 


Ser Asn Arg Ile Glu Glu Phe Arg Gln Glu Leu Phe Ala His Ile Phe 
785                 790                 795                 800 


Thr Lys Tyr Leu Asp Thr His Asp Phe Gly Trp Ile Gly Ala Ile Glu 
                805                 810                 815     


Val Arg Arg Glu Ala Cys Asp Leu Ala Asp Val Val Ser Ala Phe Glu 
            820                 825                 830         


Val Arg Asp Gln Lys Phe Asp Ala Asp Trp His Ser Gln Phe Tyr Ala 
        835                 840                 845             


Trp Leu Tyr Met Val Pro Pro Ile Glu Ala Ser Arg Leu Arg His Gln 
    850                 855                 860                 


Met Arg Lys Ser Ala Val Met Asp Asp Lys Trp Ser Thr Thr Leu Glu 
865                 870                 875                 880 


Leu Thr Ser Gly Asp Arg Lys Thr Arg Asp Asp His Ala Gln Asp Val 
                885                 890                 895     


Leu Ala Asp Met Asp Arg Leu Phe Ser Leu Tyr Thr Lys Val Gln Ala 
            900                 905                 910         


Ala Gly Phe Asn Gly Gln Glu His Glu Ser Ala Leu Gly Ser Lys Ser 
        915                 920                 925             


Leu Phe Tyr Glu Asp Gly Asn Gln Phe Asp Glu Val Tyr Ser Pro Asp 
    930                 935                 940                 


Thr Glu Thr His Asn Lys Thr Phe Pro Gly Thr Arg Arg Gly Leu Arg 
945                 950                 955                 960 


Gln Leu Val Arg Tyr Ala His Leu Pro Ala Leu Glu Gly Val Phe Lys 
                965                 970                 975     


Lys His Arg Ile Thr Lys Ala Glu Val Glu Thr Phe Val Ala Leu Tyr 
            980                 985                 990         


Asp Glu Asn Arg Arg Asp Pro Gly  Ser Val Ala His Met  Leu Arg Arg 
        995                 1000                 1005             


Glu Lys  Leu Arg Thr Glu Ile  Leu Arg Ser Ile His  Asp Gly Pro 
    1010                 1015                 1020             


Lys Pro  Lys Asp Lys Asp Phe  Trp Pro Lys Leu Glu  Ala Lys Cys 
    1025                 1030                 1035             


Leu Glu  Tyr Arg Thr Val Ala  Thr Glu Thr Ala Ile  Tyr Asn Phe 
    1040                 1045                 1050             


Gln Ala  Asn Ala Ala Arg Leu  Asn Asp His Ala Arg  Leu His Gln 
    1055                 1060                 1065             


Ile Val  Met Arg Val Val Ala  Arg Leu Thr Asp Tyr  Ala Leu Ile 
    1070                 1075                 1080             


Trp Glu  Arg Asp Arg Leu Phe  Ala Phe Val Gly Met  Leu Tyr Arg 
    1085                 1090                 1095             


Gln Thr  Gly Gly Thr Gly Ile  Asn Pro Ala Met Arg  His Ala Glu 
    1100                 1105                 1110             


Lys Thr  Asn Ala Pro Pro Arg  Ile Gly Ile Leu Val  Ser Asp Ser 
    1115                 1120                 1125             


Ala Leu  Ala Lys Lys Leu Asn  Ser Asn Ser Ala Glu  Val Phe Ile 
    1130                 1135                 1140             


Pro Tyr  Leu Asp Thr Glu Thr  Gly Phe Asp Ala Pro  Arg Phe Asp 
    1145                 1150                 1155             


Asp Leu  Cys Thr Leu Leu Ser  His Glu His Ala Lys  Glu Phe Arg 
    1160                 1165                 1170             


Phe His  Phe Leu Glu Val Gly  Glu Glu Asn Ser Lys  Asp Glu Ala 
    1175                 1180                 1185             


Arg Arg  Leu Asn Glu Glu Thr  Met Gly His Arg Lys  Arg Pro Ala 
    1190                 1195                 1200             


Phe Lys  Arg Gly Thr Arg Arg  Gln Gly Ile Arg Asn  Asp Leu Ala 
    1205                 1210                 1215             


His His  Asn Val Leu Asp Leu  Ala Gly Gly Ala Gly  Pro Asn Leu 
    1220                 1225                 1230             


Thr Tyr  Val Val Asn Ala Val  Arg Ser Leu Leu Ser  Tyr Asp Arg 
    1235                 1240                 1245             


Lys Leu  Lys Asn Ala Val Pro  Lys Ser Ile Lys Arg  Ile Leu Gly 
    1250                 1255                 1260             


Glu Glu  Gly Leu Ile Ile Glu  Trp Gln Met Asn Tyr  Asp Arg Leu 
    1265                 1270                 1275             


Lys Lys  Pro Thr Val Tyr Pro  Asn Val Glu Thr His  Leu Thr Met 
    1280                 1285                 1290             


Val Pro  Pro Arg His Met Thr  Ala Pro Val Ser Phe  Thr Leu Pro 
    1295                 1300                 1305             


Arg Ala  Ser Val Arg Leu Ala  Ser Met Val Lys Ala  Val Phe Asp 
    1310                 1315                 1320             


Phe Gly  Ser Ser Gly Tyr Gly  Glu Glu Arg Met Ile  Gly Gly Arg 
    1325                 1330                 1335             


Thr Ala  Lys Gln Ala Val Tyr  Pro Asp Asp Phe Thr  Arg Arg Phe 
    1340                 1345                 1350             


Pro Gln  Thr Pro Met Gly Leu  Lys Gln Ala Thr Arg  Leu Val Phe 
    1355                 1360                 1365             


Ala Ser  Glu Asn Ser 
    1370             


<210>  264
<211>  949
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  264

Met Pro His Gln Lys Lys Met Ala Glu Arg Ile Lys Phe Val Asn Tyr 
1               5                   10                  15      


Gly Tyr Tyr Leu Arg Leu Lys Lys Asn Cys Ala Asp Ser Phe Glu Tyr 
            20                  25                  30          


Tyr Trp Cys Asp Tyr Ile Lys Glu Phe Ile Glu Glu Asn Tyr Val Thr 
        35                  40                  45              


Lys Ile Lys Glu Ala Lys Gly Lys Asn Gly Arg Gln Leu Thr Glu Glu 
    50                  55                  60                  


Asn Cys Asn Ser Glu Ala Met Leu Ser Lys Cys Trp His Asp Met Ile 
65                  70                  75                  80  


Arg His Met Cys Ala Lys Tyr Met Asp Leu Gly Lys Ala Val Tyr His 
                85                  90                  95      


Phe Met Leu Pro Gly Lys Ala Glu Gly Asn Asp Leu Cys Leu Asp Arg 
            100                 105                 110         


Leu Asn Asp Ser Phe Ser Lys Gly Ile Thr Ser Phe Asp Tyr Glu Asn 
        115                 120                 125             


Ile Lys Ala Glu Glu Asn Leu Gln Lys Ala Met Phe Gly Val Leu Val 
    130                 135                 140                 


Ser Gly Thr Phe Asn Phe Ser Arg Ser Val Ala Asp Tyr Ser Gly Pro 
145                 150                 155                 160 


Ala Ala Ala Lys Leu Ala Lys Glu Leu Arg Ala Glu Gly Lys Thr Leu 
                165                 170                 175     


Asn Glu Asp Val Leu Met Val Asp Glu Ala His Leu Lys Ala Ile Leu 
            180                 185                 190         


Tyr Ser Asp Ala Lys Arg Lys Leu Leu Arg Tyr Phe Gly Gly Ser Ser 
        195                 200                 205             


Ala Cys Glu Ala Leu Gly Leu Asp Lys Asp Lys Met Val Leu Glu Phe 
    210                 215                 220                 


Arg Gln Ile Phe Arg Gly Leu Arg Asn Ser Ala Phe His Tyr Thr Asp 
225                 230                 235                 240 


Gly Lys Lys Ala Asp Ile Lys Phe Asp Val Thr Arg Gln Leu Trp Ile 
                245                 250                 255     


Gln Asp Val Gln Ala Asn Lys Gln Leu Ile Leu Asp Lys Tyr Tyr Ser 
            260                 265                 270         


Asn Asn Val Cys Arg Tyr Tyr Lys Pro Glu Met Val Lys Lys Leu Ile 
        275                 280                 285             


Gly Asn Leu Tyr His Gly Tyr Val Glu Gln Glu Ala Gln Ile Pro Ala 
    290                 295                 300                 


Phe Arg Thr Val Trp Lys Arg Lys Asp Phe Ala Lys Tyr Leu Asn Asp 
305                 310                 315                 320 


Ser Asn Phe Leu Pro Val Asn Ile Lys Asn Asp Val Lys Glu Arg Thr 
                325                 330                 335     


Val Phe Glu Gly Ala Leu Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg 
            340                 345                 350         


Lys Tyr Thr Val Gly Gln Asp Ala Pro Lys Tyr Phe Phe Glu Ala Val 
        355                 360                 365             


Arg Ala Tyr Ser Asp Glu His Ala Lys Asn Lys Gln Asp Pro Tyr Ala 
    370                 375                 380                 


Asn Gln Ala Lys Asn Phe Trp Asp Tyr Val Glu Lys Leu Gln Lys Ser 
385                 390                 395                 400 


Tyr Glu Lys Gly Thr Leu Thr Phe Gly Ala Val Cys Gln Thr Ile Met 
                405                 410                 415     


Thr Glu Phe Val Gln Gln Asn Ser Lys Ala Thr Glu Lys Glu Gly Glu 
            420                 425                 430         


Ile Tyr Gln His Phe Lys Val Leu Phe Pro Leu Cys Met Gln Arg Gly 
        435                 440                 445             


Phe Glu Lys Tyr Val Lys Glu Lys His Gly Tyr Leu Leu Lys Pro Trp 
    450                 455                 460                 


Leu Asp Thr Val Val Arg Glu Asn Val Leu Gln Asp Ala Ala Ile Thr 
465                 470                 475                 480 


Cys Phe Asp Asp Leu Met Arg Asp Ala Glu Asp Arg Glu Tyr Ser Trp 
                485                 490                 495     


Tyr Val Val Ala His Phe Ile His Pro Lys Lys Leu Asn His Phe Val 
            500                 505                 510         


Gly Ala Leu Lys Asp Tyr Leu Gln Phe Lys Gln Asp Ile Phe Arg Arg 
        515                 520                 525             


Cys Ser Phe Ala Asn Ile Tyr Ser Glu Gly Glu Leu Ser Gln Lys Lys 
    530                 535                 540                 


Ala Met Leu Ala Glu Lys Glu Ala Glu Ile Ser Glu Ile Leu Arg Val 
545                 550                 555                 560 


Met Glu Phe Val Arg Gly Ile Thr Gly Arg Val Ser Lys Thr Phe Ser 
                565                 570                 575     


Asp Tyr Tyr Glu Asn Glu Glu Val Tyr Ala Asn Tyr Leu Gly Lys Tyr 
            580                 585                 590         


Ile Asp Phe Pro Lys Thr Asp Gly Ile Ser Val Phe Glu Ser Phe Arg 
        595                 600                 605             


Asp Phe Cys Thr Asn Thr Leu Pro Asp Gly Asn Val Leu Asp Val Tyr 
    610                 615                 620                 


Met Asp Glu Lys Asn Pro Arg Leu Leu Lys Asn Val Glu Leu Ala Arg 
625                 630                 635                 640 


Met Tyr Ala Gly Gly Asp Val Ala Leu Lys Lys Arg Lys Arg Ile Thr 
                645                 650                 655     


Ala Lys Asp Leu Gln Arg Tyr Tyr Gly Asn Glu Val Ala Val Gln Lys 
            660                 665                 670         


Ile Leu Gln Lys Gly Leu Cys Ser Thr Arg Glu Glu Gln Gln Arg Val 
        675                 680                 685             


Leu Glu Gln Gln Asn Leu Arg Gly Arg Ile Thr Leu Asn Asp Val Thr 
    690                 695                 700                 


Glu Ile Gln Glu Ile Ile Ser Asp Met Leu Ser Gln Leu Val Thr Phe 
705                 710                 715                 720 


Ser Tyr Phe Arg Glu Arg Asp Gln Met Tyr Leu Leu Leu Gly Phe Tyr 
                725                 730                 735     


Tyr Met Ala Leu Gln Thr Asn Arg Gly Ser Ser Trp Gly Asn Glu Thr 
            740                 745                 750         


Ile Asp Phe Cys Ala Gly Lys Lys Ile Ser Ile Lys Gln Gly Trp Val 
        755                 760                 765             


Leu His Gln Val Arg Ser Val Phe Thr Tyr Gly Leu Lys Leu Tyr Ser 
    770                 775                 780                 


Glu Leu Asp Glu Lys Gly Val Gly Gly Gln Leu Ser Ser Lys Ile Val 
785                 790                 795                 800 


Ala Phe Glu Arg Val His Arg Thr Ser Leu Ala Cys Ala Leu Arg Leu 
                805                 810                 815     


Phe Met Asp Glu Asn Cys Ser Arg Arg Ala Val Asp Val Arg Asn Tyr 
            820                 825                 830         


Val Asp His Phe Lys Tyr Tyr Phe Lys Ala Asp Arg Ser Ile Met Glu 
        835                 840                 845             


Leu Tyr Ser Ala Tyr Tyr Asp Cys Phe Phe Asp Tyr Ser Thr Lys Met 
    850                 855                 860                 


Arg Lys Ser Val Leu Leu Asn Phe Ile Ser Ile Leu Glu Arg His Phe 
865                 870                 875                 880 


Val Val Ser Lys Leu Arg Val Asn Cys Leu Glu Glu Arg Cys Ser Val 
                885                 890                 895     


Ser Phe Ala Glu Ser Leu Lys Ser Glu Lys Phe Thr Tyr Lys Leu Glu 
            900                 905                 910         


Ala Asp Ala Asn Lys Lys Ser Lys Glu Gln Thr Val Glu Phe Pro Ala 
        915                 920                 925             


Arg Asp Lys Glu Phe Leu Glu Ser Leu Gln Ala Glu Leu Glu Tyr Lys 
    930                 935                 940                 


Glu Gly Tyr Asn Ser 
945                 


<210>  265
<211>  1373
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  265

Met Ala Lys His Leu Arg Pro Ile Gly Glu Ser Tyr Thr Asp Phe Leu 
1               5                   10                  15      


Asp Glu Thr Glu Phe Val Arg Leu Gly Arg Gly Leu His Arg Gly His 
            20                  25                  30          


His Gly Val Gln Ile Pro Pro Thr Glu Leu Pro Ser Tyr Leu Ala Glu 
        35                  40                  45              


Tyr Arg Lys Ala Leu Met Arg Gln Val Val Ala Val Leu Asp Lys Val 
    50                  55                  60                  


Val Gly Lys Arg Arg Arg Leu Ser Gly Met His Pro Glu Ala Tyr Arg 
65                  70                  75                  80  


Asp Arg Val His Leu Ala Glu Ala Leu Trp Val Arg Leu Val Ala Arg 
                85                  90                  95      


Val Lys Glu Ile Gly Thr Pro Pro Asp Pro Ser Glu Leu Leu Asp Leu 
            100                 105                 110         


Arg Arg Met Trp Asn Ala Lys Ala His Pro Tyr Ala Glu Tyr Asp Val 
        115                 120                 125             


Val Pro Arg Ala Pro Leu Asn Asp Gly Asn Gly Gln Lys Ile Leu Glu 
    130                 135                 140                 


Cys Arg Glu Val Asp Asp Pro Lys Ile Glu Arg Ser Asp Phe Glu Gly 
145                 150                 155                 160 


Arg Trp His Gly Arg Phe Trp Gln Ser Glu Pro Gly Pro Val Asp Tyr 
                165                 170                 175     


Asn Ala Ile Ala Asp Arg Ile Phe Ala His Leu Phe Asp Gln Glu Ala 
            180                 185                 190         


Val Ile Gly Gly Gly Pro Arg Arg Glu Gly Asn Val Thr Val Pro Asp 
        195                 200                 205             


Glu Asp Ile Asn Gly Gln Pro Gly Pro Ala Thr Gly Lys Gly Leu Ile 
    210                 215                 220                 


Ile Ala Arg Gly Gln Ser Ile Val Lys Ser Ala Ser Asp Pro Arg Arg 
225                 230                 235                 240 


Ser Ser Lys Lys Val Gln Arg Thr Trp Asp Lys Ala Val Glu Arg Arg 
                245                 250                 255     


Tyr Phe Gly Asp Asp Gly Lys Gly Gly Ser Asp Ile Ala Lys Ala Ile 
            260                 265                 270         


Tyr Glu Glu Leu Gly Asp Pro Ala Thr Leu Ala Asp Pro Ile Tyr Ala 
        275                 280                 285             


Ser Trp Phe Gly Ser Arg Leu Tyr Asp His Phe Gly Ser Phe Lys Asn 
    290                 295                 300                 


Ser Leu Pro Leu Glu Leu Lys Asp Pro Phe Lys Glu Gln Ile Trp Ala 
305                 310                 315                 320 


Leu His Asn Ser Val Arg Gln Phe Tyr Gln Arg Met Ala Lys Ser Asp 
                325                 330                 335     


Arg Phe Arg Leu Ala Leu Gln Asn Ala Arg Ser Glu Val Pro Asp Arg 
            340                 345                 350         


Ser Glu Leu Leu Ala Leu Leu Pro Lys Asp His Asp His Leu Leu Leu 
        355                 360                 365             


Val Leu Gly Gly Lys Lys Lys Asn Ala Glu Met Ser Glu Leu Ile Arg 
    370                 375                 380                 


Leu Gly Lys Leu Phe Val His Ala Ser Asp Val Leu His Asp Phe Asp 
385                 390                 395                 400 


Ala Asn Asp Ala Ala Ala Leu Asp Ala Phe Lys Arg Arg Met Ser Phe 
                405                 410                 415     


Leu Ala Thr Ser Ile Gly Gln Ser Glu Ile Lys Gln Thr Glu Thr Phe 
            420                 425                 430         


Ala Arg Thr Trp Arg Gly Ala Val Gly Leu Thr Leu Arg Thr Val Lys 
        435                 440                 445             


Gly Leu Ala Asp Pro Arg Gly Ile Ile Gly Thr Pro Asp Asn Arg Asp 
    450                 455                 460                 


Leu Gly Thr Ala Gly Pro Met Lys Asp Ala Phe Asn Lys Phe Asp Gln 
465                 470                 475                 480 


Pro His Phe Gln Gln His Met Thr Ile Ile Phe Gly Asn Lys Glu Leu 
                485                 490                 495     


Gln Ala Glu Gly Asn Pro Thr Arg Ser Ser Val Phe Thr Ala Asn Gly 
            500                 505                 510         


Asp Lys Asp His Gln Ala Glu Leu Leu Trp Gly Phe Leu Cys Val Val 
        515                 520                 525             


Arg Ser Val Arg Asn Arg Thr Asn His Tyr Asn Val Arg Arg Ala Leu 
    530                 535                 540                 


Leu Arg Leu Leu Asp Glu Gly Ile Val Ser Pro Met Pro Ser Asp Pro 
545                 550                 555                 560 


Lys Lys Glu Arg Val Glu Asn Arg Asn Leu Cys Thr Val Ser Pro Thr 
                565                 570                 575     


Ala Leu Glu Ala Phe Arg Arg Leu Leu Asn Phe Asp Leu Ala Ile Gln 
            580                 585                 590         


Lys Glu Ala Val Arg Thr Ala Leu Glu Gln Ala Lys Ala Ser Glu Phe 
        595                 600                 605             


Val Glu Glu Gly Lys Leu Arg Gly Leu Val Ser Glu Leu Ala Gly Thr 
    610                 615                 620                 


Glu Asp Met Pro Ala Leu His Ile Pro Arg Phe Ser Ala Val Met Asp 
625                 630                 635                 640 


Lys Val Arg Arg Leu Ala Asp Asn Arg Asp Val Gly Leu Asp Pro Ile 
                645                 650                 655     


Leu Ser Thr Leu Gln Arg Ser Leu Pro Pro Thr Asp Lys Gln Ala Glu 
            660                 665                 670         


Ser Asp Ala Ala Arg Cys Arg Tyr Arg Leu Leu Leu Glu Leu Tyr Lys 
        675                 680                 685             


Ser Gly Phe Arg Ser Trp Phe Ser Gly Ile Gln Ser Asn Glu Glu Asn 
    690                 695                 700                 


Asn Arg Glu Ile Cys His Trp Ala Val Lys Gln Val Gly Arg Ala Lys 
705                 710                 715                 720 


Asp Ala Arg Lys Ser Glu Tyr Asp Lys Lys Thr Lys Arg His Tyr Arg 
                725                 730                 735     


Ser Pro Asn Ser Leu Ile Asp Asp Leu Gly Leu Asp Lys Phe Asp Asp 
            740                 745                 750         


Leu Thr Asp Leu Leu Glu Ala Leu Ala Ser Gln Ser Thr Arg Glu His 
        755                 760                 765             


Asp Gln Asn Leu Lys Tyr Val Pro Asp Ala Arg Val Gln Ser Gln Met 
    770                 775                 780                 


Ser Asn Arg Ile Glu Glu Phe Arg Gln Glu Leu Phe Ala His Ile Phe 
785                 790                 795                 800 


Thr Lys Tyr Leu Asp Thr His Asp Phe Gly Trp Ile Gly Ala Ile Glu 
                805                 810                 815     


Val Arg Arg Glu Ala Cys Asp Leu Ala Asp Val Val Ser Ala Phe Glu 
            820                 825                 830         


Val Arg Asp Gln Lys Phe Asp Ala Asp Trp His Ser Gln Phe Tyr Ala 
        835                 840                 845             


Trp Leu Tyr Met Val Pro Pro Ile Glu Ala Ser Arg Leu Arg His Gln 
    850                 855                 860                 


Met Arg Lys Ser Ala Val Met Asp Asp Lys Trp Ser Thr Thr Leu Glu 
865                 870                 875                 880 


Leu Thr Ser Gly Asp Arg Lys Thr Arg Asp Asp His Ala Gln Asp Val 
                885                 890                 895     


Leu Ala Asp Met Asp Arg Leu Phe Ser Leu Tyr Thr Lys Val Gln Ala 
            900                 905                 910         


Ala Gly Phe Asn Gly Gln Glu His Glu Ser Ala Leu Gly Ser Lys Ser 
        915                 920                 925             


Leu Phe Tyr Glu Asp Gly Asn Gln Phe Asp Glu Val Tyr Ser Pro Asp 
    930                 935                 940                 


Thr Glu Thr His Asn Lys Thr Phe Pro Gly Thr Arg Arg Gly Leu Arg 
945                 950                 955                 960 


Gln Leu Val Arg Tyr Ala His Leu Pro Ala Leu Glu Gly Val Phe Lys 
                965                 970                 975     


Lys His Arg Ile Thr Lys Ala Glu Val Glu Thr Phe Val Ala Leu Tyr 
            980                 985                 990         


Asp Glu Asn Arg Arg Asp Pro Gly  Ser Val Ala His Met  Leu Arg Arg 
        995                 1000                 1005             


Glu Lys  Leu Arg Thr Glu Ile  Leu Arg Ser Ile His  Asp Gly Pro 
    1010                 1015                 1020             


Lys Pro  Lys Asp Lys Asp Phe  Trp Pro Lys Leu Glu  Ala Lys Cys 
    1025                 1030                 1035             


Leu Glu  Tyr Arg Thr Val Ala  Thr Glu Thr Ala Ile  Tyr Asn Phe 
    1040                 1045                 1050             


Gln Ala  Asn Ala Ala Arg Leu  Asn Asp His Ala Arg  Leu His Gln 
    1055                 1060                 1065             


Ile Val  Met Arg Val Val Ala  Arg Leu Thr Asp Tyr  Ala Leu Ile 
    1070                 1075                 1080             


Trp Glu  Arg Asp Arg Leu Phe  Ala Phe Val Gly Met  Leu Tyr Arg 
    1085                 1090                 1095             


Gln Thr  Gly Gly Thr Gly Ile  Asn Pro Ala Met Arg  His Ala Glu 
    1100                 1105                 1110             


Lys Thr  Asn Ala Pro Pro Arg  Ile Gly Ile Leu Val  Ser Asp Ser 
    1115                 1120                 1125             


Ala Leu  Ala Lys Lys Leu Asn  Ser Asn Ser Ala Glu  Val Phe Ile 
    1130                 1135                 1140             


Pro Tyr  Leu Asp Thr Glu Thr  Gly Phe Asp Ala Pro  Arg Phe Asp 
    1145                 1150                 1155             


Asp Leu  Cys Thr Leu Leu Ser  His Glu His Ala Lys  Glu Phe Arg 
    1160                 1165                 1170             


Phe His  Phe Leu Glu Val Gly  Glu Glu Asn Ser Lys  Asp Glu Ala 
    1175                 1180                 1185             


Arg Arg  Leu Asn Glu Glu Thr  Met Gly His Arg Lys  Arg Pro Ala 
    1190                 1195                 1200             


Phe Lys  Arg Gly Thr Arg Arg  Gln Gly Ile Arg Asn  Asp Leu Ala 
    1205                 1210                 1215             


His His  Asn Val Leu Asp Leu  Ala Gly Gly Ala Gly  Pro Asn Leu 
    1220                 1225                 1230             


Thr Tyr  Val Val Asn Ala Val  Arg Ser Leu Leu Ser  Tyr Asp Arg 
    1235                 1240                 1245             


Lys Leu  Lys Asn Ala Val Pro  Lys Ser Ile Lys Arg  Ile Leu Gly 
    1250                 1255                 1260             


Glu Glu  Gly Leu Ile Ile Glu  Trp Gln Met Asn Tyr  Asp Arg Leu 
    1265                 1270                 1275             


Lys Lys  Pro Thr Val Tyr Pro  Asn Val Glu Thr His  Leu Thr Met 
    1280                 1285                 1290             


Val Pro  Pro Arg His Met Thr  Ala Pro Val Ser Phe  Thr Leu Pro 
    1295                 1300                 1305             


Arg Ala  Ser Val Arg Leu Ala  Ser Met Val Lys Ala  Val Phe Asp 
    1310                 1315                 1320             


Phe Gly  Ser Ser Gly Tyr Gly  Glu Glu Arg Met Ile  Gly Gly Arg 
    1325                 1330                 1335             


Thr Ala  Lys Gln Ala Val Tyr  Pro Asp Asp Phe Thr  Arg Arg Phe 
    1340                 1345                 1350             


Pro Gln  Thr Pro Met Gly Leu  Lys Gln Ala Thr Arg  Leu Val Phe 
    1355                 1360                 1365             


Ala Ser  Glu Asn Ser 
    1370             


<210>  266
<211>  1287
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  266

Met Arg Ile Gly Lys Val Gln Gly Arg Thr Phe Thr Gly Phe Asp Asn 
1               5                   10                  15      


Ala Arg Gly Lys Thr Leu Arg Arg Arg Leu Leu Thr Arg Pro Asp Asn 
            20                  25                  30          


Glu Ala Arg Ser Leu Ser Glu His Leu Ala His Asp Pro Lys Ala Leu 
        35                  40                  45              


Ile Gly Gln Ala Ile Ser Arg Ile Asp Thr Ile Tyr Gln Lys Pro Lys 
    50                  55                  60                  


Thr Gly Lys Pro Thr Pro Glu Gln Phe Gly His Arg Asp Thr Leu Gly 
65                  70                  75                  80  


Trp Ala Tyr Trp Lys Leu Leu Val Ala Ser Tyr Pro Glu Val Glu Gly 
                85                  90                  95      


His Arg Asp Leu Phe Val Arg Arg Leu His Pro Tyr Gly Asp Thr Pro 
            100                 105                 110         


Pro Lys Ser His Gly Gln Lys Glu Gly Glu His Gln Lys Gly Gly Lys 
        115                 120                 125             


Pro Gln Leu Glu Gly Arg Trp His Gly Val Met Ala Gln His Gly Lys 
    130                 135                 140                 


Asn Pro Asp Gln Ile Ala Ala Arg Leu Phe Asp His Leu His Asn Ser 
145                 150                 155                 160 


Glu Leu Arg Phe Gly Gly Thr Ala Ser Gly Glu Pro Arg Thr Arg Pro 
                165                 170                 175     


Gly Lys Glu Ala Thr Pro Thr Gly Leu Ile Gly Ala Arg Ala Lys Thr 
            180                 185                 190         


Ile Glu His Ser Val Leu Pro Arg Asp Ala Lys Arg Phe Val Ala Glu 
        195                 200                 205             


Trp Arg Gly Glu Asp Gln Glu Arg Tyr Ala Gly Ala Arg Asp Ile Ala 
    210                 215                 220                 


Ala Ala Ile Ser Ala Gly Leu Asn Asp Lys Asp Gln Lys Ser Gly Ser 
225                 230                 235                 240 


Gly Arg Lys Ser Ala Val Ile Gly Lys Leu Leu Ser Asp His Leu Glu 
                245                 250                 255     


Thr Leu Thr Gly Asn Arg Lys Cys Arg Phe Asp Pro Lys Ser Thr Ala 
            260                 265                 270         


Glu Thr Leu Glu Leu Arg Asp Gly Glu Ser Val Asp Asp Arg Arg Arg 
        275                 280                 285             


Ile Leu Glu Leu His Ala Glu Val Lys Ala Thr Tyr Lys Arg Met Ala 
    290                 295                 300                 


Ala Trp Lys Pro Ala Lys Leu Pro Arg Asn Ser Asp Glu Leu Phe Arg 
305                 310                 315                 320 


Leu Val Arg Gln Gln Ala Asp Asn Arg Ile Leu Asn His Leu Val Arg 
                325                 330                 335     


Val Gly Arg Ile Ser Val Tyr Ser Glu Gln Ser Asp Ala Leu Ser Glu 
            340                 345                 350         


Ser Gln Phe Trp Thr Ser Gly Gly Gln Thr Gln Ile Lys Glu Ser Glu 
        355                 360                 365             


Val Phe Ala Arg Leu Trp Ile Gly Ala Ile Ser Arg Ala Ser Tyr Ser 
    370                 375                 380                 


Met Lys Ala Trp Leu Glu Pro Glu Gly Thr Val Phe Asn Pro Ser Ile 
385                 390                 395                 400 


Asn Asp Phe Asp Val Thr Ser Ser His Asn Thr Asn Arg Ile Leu Glu 
                405                 410                 415     


Asp Ser Gly Arg Leu Ser Asn Ala Met Ala Arg Arg Ala Ile Tyr Phe 
            420                 425                 430         


Gly Glu Thr Pro Glu Phe Asp Ala Leu Gly Glu Glu Asp Gln Arg Val 
        435                 440                 445             


Leu Val Lys Lys Cys Leu Asp Ala Leu Ser Ala Cys Arg Asn Arg Thr 
    450                 455                 460                 


Phe His His Gly Gln Arg Ala Lys Phe Leu Lys Glu Val Arg Lys Gly 
465                 470                 475                 480 


Leu Lys Glu Lys Glu Ala Asp Ser Ala Gly Pro Ala Ala Trp Glu Gly 
                485                 490                 495     


Ile Arg Glu Val Ile Gln Ala Asp Ala Arg Asn Leu Gly Ala Arg Leu 
            500                 505                 510         


Leu Gln Asp Leu Thr Gly Ala Lys Val His Ser Phe Ala Thr Asp Pro 
        515                 520                 525             


Glu Phe Arg His Leu Tyr Glu Ser Val Ala Ala Thr Leu Thr Ala Gly 
    530                 535                 540                 


Gly Glu Leu Glu Ala Ala Leu Pro Arg Leu Lys Asn Val Leu Lys Arg 
545                 550                 555                 560 


Ala Glu Gly Val Arg Cys Tyr Leu Asp Thr Pro Ser Gln Arg Arg Glu 
                565                 570                 575     


Gly Asp Glu Ser Leu Ile Ala Arg Leu Pro Val Ala Pro Val Pro Arg 
            580                 585                 590         


Glu Leu Asp Asp Ala Ala Thr Lys Ala Arg His Ser Ala Leu Leu Arg 
        595                 600                 605             


Leu Tyr Asp Gly Pro Phe Arg Pro Trp Ala Thr Glu Leu Arg Gly Glu 
    610                 615                 620                 


Arg Leu Ser Asp Tyr Ala Ala Arg Ala Lys Arg Leu Ala Thr Arg Leu 
625                 630                 635                 640 


Ala Lys Ser Thr Asn Thr Ala Ser Pro Tyr Pro Asp Ser Val Glu Gly 
                645                 650                 655     


Arg Ser Val Arg Leu Arg Asp Pro Ile Thr Ala Asp Thr Ala Pro Glu 
            660                 665                 670         


Thr Leu Lys Thr Tyr Leu Ser Ala Leu Thr Ala Glu Thr Ala Thr Glu 
        675                 680                 685             


Phe Arg Val Gln Lys Gly Tyr Glu Ser Asp Gly Glu Lys Ala Lys Glu 
    690                 695                 700                 


Gln Ala Glu Phe Ile Glu Asp Phe Arg Arg Asp Met Ile Ala Leu Ala 
705                 710                 715                 720 


Phe Gln Asp Phe Ile Arg Asp His Gly Phe Ala Trp Leu Leu Asp Ile 
                725                 730                 735     


Ala Ser Lys Ala Glu Pro Ser Asn Asp Ala Pro Asn Leu Pro Asp Pro 
            740                 745                 750         


Val Asp Thr Gly Lys Asp Thr Val Phe Glu Asp Trp Gln Ala Leu Leu 
        755                 760                 765             


Tyr Leu Phe Leu His Phe Val Pro Ala Asp Asp Val Ser Gln Leu Leu 
    770                 775                 780                 


His Gln Leu Arg Lys Trp Asp Ala Leu Gln Asp Lys Tyr Glu Leu Ala 
785                 790                 795                 800 


Glu Pro Gly Glu Thr Leu Gly Gln Thr Lys Ala Asp Thr Arg Lys Ile 
                805                 810                 815     


Val Gly Gln Phe Arg Asp Cys Leu Thr Leu Phe Leu Lys Thr Gly Asp 
            820                 825                 830         


Ala Arg Phe Asp Gly Glu Gly Val Glu Leu Pro Leu Ser Asp Phe Gln 
        835                 840                 845             


Glu Leu Phe Glu Ser Pro Ala Thr Phe Lys Glu Leu Phe Leu Ala Glu 
    850                 855                 860                 


Pro Ala Glu Asn Asp Ala Ser Glu Thr Asp Asp Gln Asp Ala Pro Gly 
865                 870                 875                 880 


Glu Lys His Arg Val Thr Arg Thr Arg Arg Gly Leu Arg Gln Ile Leu 
                885                 890                 895     


Arg Tyr Asn His Met Pro Val Leu Arg Asp Leu Phe Leu Ala His Lys 
            900                 905                 910         


Val Thr Asp Ala Glu Val Asp Gly Leu Gln Ala Leu Glu Val Asp Asp 
        915                 920                 925             


Pro Gln Thr Gly Glu Ser Gln Ile Gly Ala Ala Gln Arg Ile Arg Thr 
    930                 935                 940                 


Glu Ile His His His Thr Ser Asn Asp Lys Gln Ile Ser Glu Ala Lys 
945                 950                 955                 960 


Val Glu Glu Tyr Arg Arg Ala Leu Ser Thr Ile Glu Arg His Arg Phe 
                965                 970                 975     


Leu Val Gly Arg Val Tyr Leu Gly Asp His Ile Arg Val His Lys Leu 
            980                 985                 990         


Met Met Asp Val Met Gly Arg Leu  Val Asp Phe Ala Gly  Ala Trp Glu 
        995                 1000                 1005             


Arg Glu  Ala Ala Asp Gly Asp  Arg Lys Gly Phe Ile  Ser Arg Ala 
    1010                 1015                 1020             


Ile Ala  Leu Pro Glu Val Ala  Glu Gly Tyr Ala Ala  Asp Arg Leu 
    1025                 1030                 1035             


Lys Thr  Val Ala Arg Arg Val  Leu Asp Asp Gly Glu  Ala Arg Arg 
    1040                 1045                 1050             


Ile Arg  Asn Asp Leu Gly His  Phe Asn Asp Leu Ala  Pro Thr Ser 
    1055                 1060                 1065             


Gly Pro  Ala Asn Leu Thr Phe  Val Val Asn Arg Ala  Arg Arg Met 
    1070                 1075                 1080             


Met Arg  His Asp Arg Lys Arg  Lys Asn Ala Val Thr  Lys Ser Val 
    1085                 1090                 1095             


Ile Glu  Ile Leu Asn Arg Gln  Gly Leu Gly Ile Glu  Trp Thr Met 
    1100                 1105                 1110             


Arg Asn  His Glu Leu Cys Glu  Ala Lys Leu Trp Gln  Asn Pro Val 
    1115                 1120                 1125             


Lys His  Leu Gly Phe Ala Thr  Leu Glu Gly Arg Gly  Lys Lys Trp 
    1130                 1135                 1140             


Arg Arg  Pro Phe Glu Ala Arg  Tyr Gly Asp Ala Tyr  Met Ala Met 
    1145                 1150                 1155             


Val Ala  Gln Leu Phe Asp Gly  Thr Val Thr Ser Pro  Pro Ala Lys 
    1160                 1165                 1170             


Gly Pro  Pro Gln Ser Gly Lys  Ser Gly Gly Lys Pro  Gly Lys Gly 
    1175                 1180                 1185             


Ala Glu  Gly Gly Ala Lys Glu  Lys Ser Arg Ser Pro  Thr Arg Met 
    1190                 1195                 1200             


Glu Glu  Gly Gly Val Tyr Glu  Gly Arg Val Ala Lys  Ala Lys Ser 
    1205                 1210                 1215             


Asp Lys  Gly Phe Gly Phe Leu  Leu Val Glu Gly Ala  Gln Glu Glu 
    1220                 1225                 1230             


Ile Phe  Leu His Ile Tyr Gly  Ile Ser Gly Asn Arg  Pro Ala Arg 
    1235                 1240                 1245             


Ile Glu  Asn Gly Gln Arg Tyr  Arg Phe Thr Leu Gly  Ile Asp Arg 
    1250                 1255                 1260             


Asp Arg  Glu Arg Arg Lys Glu  Arg Ala Trp Val Ala  Arg Glu Ala 
    1265                 1270                 1275             


Val Arg  Ile Asp Glu Asn Arg  Ser Lys 
    1280                 1285         


<210>  267
<211>  1425
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  267

Met Lys Leu Ser Lys Val Asp Arg Ile Arg Val Ala Val Gly Lys Thr 
1               5                   10                  15      


Gly Lys Thr Glu Asn Gly Asn Ser Gln Gly Arg Gly Val Leu Tyr Arg 
            20                  25                  30          


Ser Pro Lys Gly Asn Lys Thr Val Ala Val Asp Ala Val Val Glu Glu 
        35                  40                  45              


Arg Ile Arg Asn Ala Asn Arg Leu Tyr Ser Ala Phe Phe Arg Cys Ala 
    50                  55                  60                  


Tyr Pro Glu Glu Pro Glu Arg His Phe Glu Glu Ile Ile Lys Arg Met 
65                  70                  75                  80  


Ala Thr Gly Lys Lys Ser Gly Ala Gln Ile Leu Lys Glu Tyr Ile Gly 
                85                  90                  95      


Tyr Glu Gly Gln Lys Asn Arg Lys Pro Tyr Thr Phe Tyr Val Asn Lys 
            100                 105                 110         


Cys Ala Tyr Arg Pro Ala Gly Lys Glu Leu Gly Gln Val Leu Arg Leu 
        115                 120                 125             


Phe Val Lys Glu Arg Leu Gly Gln Asn Trp Gln Asn Pro Glu Ala Ala 
    130                 135                 140                 


Glu Ala Ala Val Ala Leu Leu Thr Cys Leu Cys Glu Gly Lys Thr Asn 
145                 150                 155                 160 


Arg Tyr Thr Glu Asn Thr Ala Asp Gly Pro Val Leu Thr Glu Leu Ser 
                165                 170                 175     


Glu Gln Thr Val Thr Gln Leu Glu Gln Val Ser Arg Leu Gly Gly Ser 
            180                 185                 190         


Ile Leu Val Pro Lys Thr Glu Arg Leu Glu Thr Ile Val Thr Val Ile 
        195                 200                 205             


Leu Arg Leu Thr Ala Glu Gln Cys Asn Thr Ser Leu Tyr Val Asn Gly 
    210                 215                 220                 


Gly Thr Lys Glu Ala Gln Asp Ala Asp Leu Glu Lys Gln Ile Ala Leu 
225                 230                 235                 240 


Leu Lys Ser Leu Gln Thr Lys Pro Leu Leu Leu Lys Glu Arg Phe Asp 
                245                 250                 255     


Lys Val Thr Lys Gln Thr Ile Arg Asp Glu Gln Lys Leu Ser Glu Phe 
            260                 265                 270         


Ser Tyr Lys Asp Ala Thr Lys Glu Arg Met Glu Ala Val Val Val Arg 
        275                 280                 285             


Met Arg Lys Thr Leu Lys Lys Gly Ala Ser Arg Glu Val Ala Val Glu 
    290                 295                 300                 


Leu Leu Gln Ala Leu Ala Gln Tyr Asp Gly Lys Thr Trp Asp Gly Trp 
305                 310                 315                 320 


Leu Thr Gln Met Leu Glu Thr Glu Ala Ser Lys Lys Lys Leu Lys Asp 
                325                 330                 335     


Phe Ile Leu Ala Val Asn Lys Asp Phe His His Phe His Val Ile Lys 
            340                 345                 350         


Ser Val Lys Asn Thr Ala Val Ala Val Ser His Ser Glu Asp Asn Thr 
        355                 360                 365             


Leu Gln Leu Ser Gly Ala Lys Lys Lys Thr Lys Gly Ala Met Gln Asp 
    370                 375                 380                 


Ala Leu Phe Ala Tyr Ala Gln Ser Glu Glu Ser Ser Asp Glu Thr Leu 
385                 390                 395                 400 


His Arg Ile Lys Arg Ile Leu Phe Thr Tyr Val Leu Gly Gly Arg Gln 
                405                 410                 415     


Asp Asn Thr Leu Arg Leu Thr Glu Lys Thr His Leu Ala Lys Glu Leu 
            420                 425                 430         


Leu Trp Lys Phe Arg Gly Thr Gly Ala Gly Leu Phe Asp Ala Asp Phe 
        435                 440                 445             


Val Pro Glu Glu Glu Arg Ala Gly Glu Ser Gly Arg Lys Ala Gly Ser 
    450                 455                 460                 


Tyr Thr Asp Leu Gly Cys Leu Phe Ala Glu Asp Asp Gly Ile Arg Asn 
465                 470                 475                 480 


Gln Arg Arg Ile Ala Asp Arg Ile Asn Tyr Val Asn Tyr Gly Asn Tyr 
                485                 490                 495     


Leu Arg Met Arg Lys Ala Ala Glu Asp Glu Phe Thr Leu Phe Trp Cys 
            500                 505                 510         


Ala Tyr Ile Lys Asp Tyr Ile Glu Glu Asn Tyr Val Thr Lys Ile Arg 
        515                 520                 525             


Glu Ala Lys Arg Thr Gly Gly Lys Arg Arg Leu Lys Glu Thr Asp Cys 
    530                 535                 540                 


Glu Ala Glu Arg Met Met Glu Lys Cys Trp His Asp Ile Ile Arg Tyr 
545                 550                 555                 560 


Ile Cys Gly Lys Tyr Ile His Ile Gly Lys Ala Val Tyr His Phe Ala 
                565                 570                 575     


Ile Pro Glu Asp Leu Leu Ala Asn Pro Gly Glu Val Arg Ser Phe Gly 
            580                 585                 590         


Asp Val His Ala Lys Tyr Ala Asp Gly Ile Thr Ser Phe Asp Tyr Glu 
        595                 600                 605             


Asp Ile Lys Ala Glu Glu Asn Leu Gln Lys Ser Ile Phe Asn Val Leu 
    610                 615                 620                 


Val Ser Ala Val Ala Asn Tyr Ser Arg Ser Val Val Asp Leu Ser Ser 
625                 630                 635                 640 


Glu Arg Ala Glu Glu Leu Arg Arg Leu Pro Gly Asn Glu Arg Leu Asn 
                645                 650                 655     


Glu Asp Val Leu Met Met Lys Glu Thr His Leu Lys Glu Leu Leu Leu 
            660                 665                 670         


Pro Asp Ala Lys Lys Arg Leu Leu Arg Tyr Phe Gly Gly Tyr Ser Ala 
        675                 680                 685             


Cys Glu Gly Leu Ser Gly Val Thr Ser Glu Glu Leu Ala Trp Glu Met 
    690                 695                 700                 


Arg Thr Val Leu Ser Thr Leu Arg Asn Glu Ser Phe His Tyr Thr Phe 
705                 710                 715                 720 


Gly Lys Lys Lys Lys Leu Asp Tyr Lys Val Ala Lys Gln Leu Trp Met 
                725                 730                 735     


Gln Ala Ile Arg Ala Asn Arg Gln Leu Ile Leu Asp Lys Tyr Tyr Ser 
            740                 745                 750         


Asn Asn Thr Cys Arg Tyr Tyr Ser Pro Asn Ser Ile Lys Ala Leu Ile 
        755                 760                 765             


Glu Gln Gly Tyr Arg Ser Tyr Glu Glu Arg Glu Ala Gln Ile Pro Ala 
    770                 775                 780                 


Phe Lys Thr Val Trp Lys Lys Ala Glu Leu Ala Lys Tyr Leu Ala Asp 
785                 790                 795                 800 


Lys Lys Val Met Pro Ala Glu Ile Ser Gly Glu Glu Lys Glu Arg Val 
                805                 810                 815     


Ile Phe Gln Gly Ala Phe Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg 
            820                 825                 830         


Glu Phe Thr Val Gly Asn Thr Ala Ala Lys Tyr Phe Phe Asp Ala Val 
        835                 840                 845             


Glu Arg Tyr Cys Lys Glu Asn Glu Thr Gly Pro Tyr Lys Asn Pro Ala 
    850                 855                 860                 


Lys Ser Phe Asn Asp Tyr Val Asn Gly Ala Phe Asn Asn Lys Gly Val 
865                 870                 875                 880 


Lys Val Gln Lys Gly Leu Ser Asp Leu Tyr Arg Glu Gly Lys Ile Thr 
                885                 890                 895     


Phe Gly Val Val Cys Gln Thr Ile Met Ala Glu Tyr Thr Gln Gln Asn 
            900                 905                 910         


Glu Lys Ser Glu Gly Glu Ala Ile Tyr Gln His Phe Lys Met Leu Phe 
        915                 920                 925             


Pro Leu Cys Met Arg Lys Gly Phe Gln Lys Tyr Val Glu Glu Lys His 
    930                 935                 940                 


Lys Glu Leu Leu Gln Pro Val Ile Arg Glu Met Gly Ser Arg Glu Asp 
945                 950                 955                 960 


Phe Leu Thr Asn Ile His Ile Gly Cys Phe Asp Asp Phe Cys Arg Glu 
                965                 970                 975     


Asp Gly Met Tyr Glu Tyr Asp Trp Phe Val Val Ala His Leu Ile His 
            980                 985                 990         


Pro Lys Arg Leu Asn Glu Leu Val  Gly Asn Leu Lys Asp  Tyr Met Gln 
        995                 1000                 1005             


Phe Lys  Gln Asp Ile Leu Arg  Arg Ala Asp Tyr Val  Glu Gln Phe 
    1010                 1015                 1020             


Thr Lys  Glu Glu Leu Ala Ala  Met Lys Ala Arg Thr  Glu Glu Lys 
    1025                 1030                 1035             


Leu Gln  Lys Ile Ser Gly Ile  Leu Arg Val Ala Glu  Phe Val Arg 
    1040                 1045                 1050             


Gly Ile  Ala Gly Arg Val Ser  Asn Thr Phe Ser Asp  Tyr Tyr Glu 
    1055                 1060                 1065             


Ser Glu  Glu Ala Tyr Ala Ser  Tyr Leu Glu Gln Tyr  Ile Glu Phe 
    1070                 1075                 1080             


Pro Arg  Ile Lys Gly Ser Thr  Val Phe Glu Ser Phe  Arg Asp Phe 
    1085                 1090                 1095             


Cys Val  Asn Thr Leu Pro Gly  Gly Ala Val Met Asp  Val Tyr Met 
    1100                 1105                 1110             


Asp Glu  Lys Asn Pro Arg Ile  Leu Arg Asn Val Glu  Val Ala Arg 
    1115                 1120                 1125             


Met Tyr  Ala Gly Gly Asp Ile  Gly Leu Arg Thr Arg  Lys Lys Val 
    1130                 1135                 1140             


Thr Ala  Glu Glu Leu Lys Arg  Tyr Tyr Gln Asn Glu  Ala Glu Val 
    1145                 1150                 1155             


Ala Ala  Leu Leu Lys Ala Gly  Leu Cys Ala Thr Ala  Glu Asp Gln 
    1160                 1165                 1170             


Lys Arg  Val Lys Ala Gln Gln  Glu Leu Arg Asn Arg  Ile Thr Leu 
    1175                 1180                 1185             


Thr Asp  Val Thr Glu Ile Gln  Glu Val Ile Asn Asp  Leu Leu Ser 
    1190                 1195                 1200             


Gln Leu  Val Thr Phe Ser Tyr  Phe Arg Glu Arg Asp  Glu Met Tyr 
    1205                 1210                 1215             


Leu Leu  Leu Gly Phe Tyr Tyr  Met Ala Leu Gln Ser  Asp Gly Asp 
    1220                 1225                 1230             


Trp Gly  Glu Glu Leu Arg Val  Phe Asp Gly Lys Lys  Leu Gln Val 
    1235                 1240                 1245             


Glu Asn  Gly Phe Val Leu Tyr  Gln Leu Leu Ser Ala  Phe Thr Tyr 
    1250                 1255                 1260             


Gly Leu  Asn Met Tyr Ser Glu  Ala Ala Pro Asp Gly  Lys Gly Gly 
    1265                 1270                 1275             


Ser Gln  Ala Gly Lys Ile Gly  Glu Phe Ile Lys Ala  His Pro Asn 
    1280                 1285                 1290             


Ser Trp  Asp Arg Ala Leu Arg  Leu Phe Val Asp Asp  Gly Ala Cys 
    1295                 1300                 1305             


Glu Glu  Val Ser Arg Lys Ala  Arg Asn Tyr Val Asp  His Phe Arg 
    1310                 1315                 1320             


Tyr Tyr  Val Lys Pro Asp Arg  Ser Ile Met Asp Leu  Tyr Ala Val 
    1325                 1330                 1335             


Tyr His  Glu Tyr Phe Phe Asp  Tyr Ser Thr Lys Met  Arg Lys Ser 
    1340                 1345                 1350             


Val Leu  Gln Asn Phe Ala Ser  Ile Leu Glu Arg Tyr  Phe Val Leu 
    1355                 1360                 1365             


Thr Lys  Phe Lys Leu Gly Gly  Glu Arg Gly Ala Gln  Thr Leu Glu 
    1370                 1375                 1380             


Ala Glu  Leu Ser Gly Asp Lys  Phe Thr Tyr Lys Leu  Ser Asp Thr 
    1385                 1390                 1395             


Lys Ala  Lys Pro Val Val Leu  Pro Ala Arg Asn Lys  Glu Phe Leu 
    1400                 1405                 1410             


Glu Asn  Leu Lys Asn Glu Leu  Asn Tyr Arg Gln Glu  
    1415                 1420                 1425 


<210>  268
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  268

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Thr Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Leu Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Phe Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Arg Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Lys Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Glu 
        755                 760                 765             


Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val His Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1400                 1405                 1410         


<210>  269
<211>  1222
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  269

Met Arg Ile Thr Lys Val Lys Val Glu Ala Gly Lys Pro Asp Glu Asn 
1               5                   10                  15      


Lys Gly Lys Met Val Leu Ile His Arg Lys Ile Lys Gln Gly Asn Leu 
            20                  25                  30          


Ile Leu Glu Asp Phe Ser Lys Ser Glu Arg Thr Gly Thr Ser His Lys 
        35                  40                  45              


Glu Leu Pro Asp Cys Thr Lys Ser Val Leu Tyr Glu Tyr Lys Asn Glu 
    50                  55                  60                  


Ser Phe Glu Leu Ser Leu Ser Lys Gln Thr Ile Ala Gly Asp Lys Glu 
65                  70                  75                  80  


Leu Lys Thr Pro Arg Cys Lys Gln Cys Gln Asp Arg Thr Asp Cys Lys 
                85                  90                  95      


Ala Cys Lys Asp Arg Thr Lys Ala Ile Lys Glu Leu Arg Lys Lys Val 
            100                 105                 110         


Glu Gly Leu Ile Lys Glu Val Ile His Val Ala Val Glu Lys Gln Glu 
        115                 120                 125             


Lys Thr Glu Tyr Ser Ala Arg Phe Asn Thr Ala Thr Ser Glu Asp Asp 
    130                 135                 140                 


Met Arg Cys Cys Leu Lys Thr Lys Phe Gln Gly Ile Leu Arg Tyr Lys 
145                 150                 155                 160 


Ser Thr Thr Gly Glu Ser Phe Glu Leu Asn Leu Pro Lys Cys Leu Ala 
                165                 170                 175     


Ala Tyr Ser Gln Thr Lys Asp Ala Lys Thr Leu Thr Pro Tyr Arg Asp 
            180                 185                 190         


Trp Ile Asp Ser Tyr Leu Gln Lys Lys Arg Ser Phe Leu Glu Lys Ser 
        195                 200                 205             


Ile Leu Asn Asn Arg Ile Val Val Asn Cys Ser Asn Glu Asp Thr Glu 
    210                 215                 220                 


Gln Leu Ser Lys Arg Lys Gln Ala Leu His Leu Trp Ala Asn Glu Tyr 
225                 230                 235                 240 


Glu Thr Lys Lys Lys Ile Glu Leu Gly Thr Leu Cys Ser Lys Tyr Asn 
                245                 250                 255     


Ile Asn Ala Leu Ser Thr Ser Leu Asn Asn Lys Phe Asn Ser Leu Leu 
            260                 265                 270         


Gln Ser Gly Lys Gly Ile Lys Lys Ser Lys Phe Pro His Arg Gly Pro 
        275                 280                 285             


Asp Leu Val Asp Ala Asn Thr Asn Phe Glu Leu Lys Lys Glu Leu Gln 
    290                 295                 300                 


Leu His Gln Ser Ser Val Phe Gly Thr Lys Ala Thr Leu Val Ile Asn 
305                 310                 315                 320 


Asn Ile Phe Lys Glu Asn Arg Glu Asn Val Gln Leu Ala Ile Tyr Asn 
                325                 330                 335     


Leu Glu Val Val Lys Tyr Leu Glu His Tyr Phe Pro Ile Lys Arg Lys 
            340                 345                 350         


Lys Gln Leu Leu Thr Val Asp Gln Val Arg Tyr Tyr Leu Lys Glu Thr 
        355                 360                 365             


Thr Ile Arg Glu Arg Val Gln Met Gln Leu Glu Asn Ala Ile Arg Met 
    370                 375                 380                 


His Leu Leu Gln Gln Gly Lys Leu Glu Asn His Asn Leu Lys Glu Asp 
385                 390                 395                 400 


Val Asp Ser Asn Ala Leu Ser Val Ile Lys Arg Asp Glu Phe Phe Met 
                405                 410                 415     


Leu Asn Phe Val Glu Met Cys Ala Phe Ala Ala Asn Asn Ile Arg Asn 
            420                 425                 430         


Ile Ile Asp Lys Glu Gln Val Asn Asp Ile Leu Gly Lys Ser Asp Phe 
        435                 440                 445             


Glu Arg Ser Leu Ala Lys Gly Asn Phe Asp Glu Asn Arg Tyr Lys Leu 
    450                 455                 460                 


Phe Tyr Gly Val Asp Leu Lys Ser Asp Thr Ser His Ser Ala Phe Asp 
465                 470                 475                 480 


Ile Gln Ala Leu Trp Ala Met Arg Gly Ala Val Gln Gln Ile Arg Asn 
                485                 490                 495     


Glu Val Ile His Tyr His Thr Asp Thr Leu Asn Lys Ile Phe Lys Leu 
            500                 505                 510         


Asp Lys Phe Glu Tyr Lys Asp Asp Ala Asn Ala Glu Glu Cys Lys Tyr 
        515                 520                 525             


Thr Asn Thr Val Phe Gln Thr Leu Leu Glu Ser Ser Ile His Gln Leu 
    530                 535                 540                 


Asp Glu Tyr Phe Ile Glu Gln Leu Arg Ser Asn Asn Val Leu Ser Tyr 
545                 550                 555                 560 


Tyr Ala Leu Asp Ser Leu Asn His Leu Leu Gly Tyr Cys Thr Ile Ser 
                565                 570                 575     


Leu Arg Lys Ser Ser Ile Pro Phe Ala Pro Gly Phe Lys Asn Val Tyr 
            580                 585                 590         


Ala Leu Gly Ala Asn Leu Gln Tyr Gly Asn Thr Ser Met Asn Leu Lys 
        595                 600                 605             


Asn Tyr Leu Leu Lys Asp Glu Lys Gly Gln Ser Ile Asp Pro Thr Lys 
    610                 615                 620                 


Thr Lys Ser Ser His Ala Tyr Pro Ala Phe Arg Phe Ile Leu Lys Leu 
625                 630                 635                 640 


Val Tyr Asn His Ile Phe Leu Ser Arg Phe Leu Asp Asn Thr Gln Gln 
                645                 650                 655     


Asp Ala Phe Lys Glu Ala Val Thr Phe Val Leu Gln Asn Asn Arg Glu 
            660                 665                 670         


Glu Ala Ala Lys Ala Thr Lys Pro Thr Lys Gly Lys Pro Asn Phe His 
        675                 680                 685             


Ser His Gln Asp Lys Gln Glu Pro Glu Lys Tyr Ala Phe Lys Glu Ile 
    690                 695                 700                 


Arg Glu Met Gln Val Gly Glu Thr Ile Ser Ser Tyr Met Ser Tyr Ile 
705                 710                 715                 720 


His Ser Tyr Ser Val Gln Glu Lys Glu Arg Lys Gly Asp Glu Asn Asp 
                725                 730                 735     


Asn Thr Arg His Asn Thr Asp Lys Phe Ile Glu Lys Val Phe Thr Lys 
            740                 745                 750         


Gly Phe Asp Ser Phe Leu Ser Thr Leu Pro Thr Ala Phe Leu Tyr Ser 
        755                 760                 765             


Pro Glu Asp Glu Gln Glu Val Glu Asn Glu Asp Tyr Gln Ala Leu Ala 
    770                 775                 780                 


Ile Gly Gln Gln Val Gln His Cys Ile Lys Ser Asp Asn Gly Thr His 
785                 790                 795                 800 


Ile Leu Phe Phe Thr Phe Cys Lys Leu Leu Asp Gly Asn His Leu Ser 
                805                 810                 815     


Asp Leu Arg Asn Glu Trp Leu Lys Tyr Tyr Ala Ser Asp Arg Thr Asp 
            820                 825                 830         


Ser Phe His Tyr Asp Phe Ala Leu Asp Ile Ile Glu Leu Cys Leu Leu 
        835                 840                 845             


Gly Lys Asp Lys Glu Ile Val Pro Thr Lys Glu Asp Ile Ile Cys Tyr 
    850                 855                 860                 


Ile Asn Thr Phe Val Glu Gly Asn Glu Lys Ser Asn Arg Ala Trp Thr 
865                 870                 875                 880 


Glu Phe Tyr Phe Gln Ser Asp Gln Asn Pro Val Glu Tyr Ala Ser Ile 
                885                 890                 895     


Asn Leu Leu Arg Lys His Gly Thr Leu Glu Leu Leu Lys Leu Ile Val 
            900                 905                 910         


Gly Asp Thr Tyr Lys Val Thr Gln Arg Asp Tyr Asp Glu Trp Lys Thr 
        915                 920                 925             


Leu Lys Glu Ser Ile Glu Asn Asp Val Asn Glu Arg Glu Ile Ile His 
    930                 935                 940                 


Lys Glu Trp Val Glu Leu Glu Asn Lys Arg Thr Glu Trp Tyr Lys Lys 
945                 950                 955                 960 


Asn Gly Arg Pro Ser Asn Lys Ala Glu Lys Asp Lys Ile Asn Arg Met 
                965                 970                 975     


Phe Gln Leu Pro Asp Ser Arg Leu Asn Lys Tyr Lys Glu Leu Cys Ile 
            980                 985                 990         


Arg Ile Glu Arg Tyr Asn Trp Leu  Asp Asn Lys Leu His  Leu Val His 
        995                 1000                 1005             


Leu Lys  Lys Leu His Asn Leu  Ile Val Gln Leu Leu  Ser Arg Met 
    1010                 1015                 1020             


Ala Arg  Phe Val Ala Leu Trp  Asp Arg Asp Phe Val  His Leu Asp 
    1025                 1030                 1035             


Ala Ser  Arg Thr Glu Asp Glu  Tyr Arg Leu Thr Ser  Phe Val Asn 
    1040                 1045                 1050             


Leu Arg  Asn Leu Lys Tyr Glu  Ala Asp Asn Lys Lys  Phe Met Asp 
    1055                 1060                 1065             


Asn Tyr  Gln Asp Ser Ile Tyr  Arg Lys Asp Gly Ser  Lys Ile Glu 
    1070                 1075                 1080             


Glu His  Asp Ile Pro Leu Ile  Lys Thr Cys Val Asn  Asn Ile Lys 
    1085                 1090                 1095             


Gln Pro  Leu Tyr Arg Glu Thr  Phe Phe Met Lys Asn  Asp Asn Ala 
    1100                 1105                 1110             


Phe Ser  Asp Arg Asn Phe Ile  Ala His Phe Asn Tyr  Ile Thr Lys 
    1115                 1120                 1125             


Ser Ala  Glu His Ser Met Val  Asp Leu Val Asn Arg  Leu Arg Met 
    1130                 1135                 1140             


Leu Met  Ala Tyr Asp Arg Lys  Leu Arg Asn Ala Val  Ser Lys Ser 
    1145                 1150                 1155             


Ile Ile  His Val Phe Glu Gln  Asn Gly Met Glu Leu  Lys Phe Lys 
    1160                 1165                 1170             


Cys Ile  Thr Arg Gly Glu Thr  Glu His Lys Leu Glu  Leu Glu Ser 
    1175                 1180                 1185             


Ile Lys  Ser Lys Lys Met Ser  Leu Leu Lys Gly Lys  Leu Glu Ile 
    1190                 1195                 1200             


Asp Gln  Val Ser Glu Glu Tyr  Cys Arg Leu Cys Lys  Arg Leu Leu 
    1205                 1210                 1215             


Glu Met  Lys Lys 
    1220         


<210>  270
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  270

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Asp Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn Tyr Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Gly Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Gly Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Lys Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Arg Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Asp Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  271
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  271

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  272
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  272

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Thr Glu Asn Lys Asn Glu Glu Gln Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Leu Lys Lys Asn Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Ser Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Cys Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Thr Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Ile Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Gln Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Lys 
                405                 410                 415     


Arg Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Ile Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Ala Leu Glu Gly Glu Ser 
    450                 455                 460                 


Val Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Glu Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Ala Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Lys Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Lys Asp Asp Glu Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Ser Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Lys Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Ala Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Val Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Glu Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Lys Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  273
<211>  1358
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  273

Met Lys Ile Ser Lys Glu Gly His Lys Arg Met Ser Val Thr Leu Lys 
1               5                   10                  15      


Lys Glu Asn Met Gln Lys Asn Asp Ala Asp Lys Thr Lys Gly Gln Ile 
            20                  25                  30          


Leu Pro Leu Pro Glu Gly Glu Gly Leu Glu Lys Tyr Ile Gln Lys Arg 
        35                  40                  45              


Val Ala Asn Thr Gln Lys Leu Tyr Lys Val Leu Gly Pro Ser Ala Val 
    50                  55                  60                  


Ser Val Pro Asn Glu Lys Glu Lys Glu Thr Ile Asp Cys Phe Asn Asp 
65                  70                  75                  80  


Phe Ile Lys Asn Ile Ile Leu Lys Asn Val Asn Thr Gln Pro Ala Glu 
                85                  90                  95      


Lys Arg Asn Arg Asn Ala Val Glu Tyr Met Lys Thr Lys Gly Asn Val 
            100                 105                 110         


Asn Thr Val Phe Ile Asp Val Asp Arg Lys Cys Ile His Lys Leu Val 
        115                 120                 125             


Pro Leu His Leu Arg Gly Thr Leu Lys Lys Tyr Val Lys Ile Glu Lys 
    130                 135                 140                 


Asp Gly Gln Arg Ile Glu Val Tyr Ile Pro Asp Val Ile Glu Lys Leu 
145                 150                 155                 160 


Val Phe Ala Val Ala His Gly Thr Gln Phe Asp His Leu Ile Ala Glu 
                165                 170                 175     


Ile Glu Glu Glu Glu Leu Ile Val Cys Leu His Met Ile Phe Lys Asp 
            180                 185                 190         


Tyr Thr Lys Glu Asp Ile Ile Ala Asn Thr Ala Lys Ser Ile Glu Lys 
        195                 200                 205             


Gln Asp Val Lys Val Gln Val Leu Gly Thr Gly Glu Asp Ala Arg Leu 
    210                 215                 220                 


Gln Leu Ala Ser Ala Asp Asn Glu Lys Lys Lys Tyr Ile Phe Leu Phe 
225                 230                 235                 240 


Leu Lys Lys Phe Ala Cys Ala Val Ser Glu Lys Glu Arg Asn Asp Leu 
                245                 250                 255     


Leu Arg Glu Phe Arg Glu Leu Leu Val Leu Phe Tyr Cys Gly Thr Ala 
            260                 265                 270         


Ala Tyr Glu Glu Val Lys Glu Trp Lys Asn Gly Ile Pro Ile Trp Asp 
        275                 280                 285             


Phe Asp Phe Leu Ser Lys Met Val Ser Asp Ile Ser Trp Phe Phe Ser 
    290                 295                 300                 


Gln Glu Cys Ser Glu Lys Leu Met Glu Arg Glu Gln Leu Arg Arg Glu 
305                 310                 315                 320 


Lys Asp Lys Asp Lys Lys Arg Gln Asn Lys Ser Lys Ile Lys Asp Ile 
                325                 330                 335     


Asp Val Glu Val Lys Gly Ile Leu Ala Asn Leu Ile Thr Glu Arg Tyr 
            340                 345                 350         


Arg Glu Ser Ile Lys Leu Leu Gln Ser Leu Leu Gly Glu Glu Glu Tyr 
        355                 360                 365             


Lys Glu Lys Cys Phe Trp Leu Glu Tyr Ile Glu Asn Asp Ala Glu Lys 
    370                 375                 380                 


Ile Leu Cys Ser Lys Lys Ala Leu Thr Glu Asn Lys Leu Asp Thr Val 
385                 390                 395                 400 


Trp Leu Cys Asn Asn Thr Trp Arg Asn Phe Leu Ser Phe Leu Cys Ser 
                405                 410                 415     


Lys Ala Val Asp Met Gly Lys Ala Val Tyr His Phe Ala Met Pro Asp 
            420                 425                 430         


Leu Glu Gln Leu Glu Ser Gly Glu Pro Ile Lys Ala Gly Met Ile Lys 
        435                 440                 445             


Pro Gln Phe Gln Gln Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys 
    450                 455                 460                 


Ala Glu Glu Asn Leu Glu Arg Ser Phe Met Thr Ala Ile Ser Phe Ala 
465                 470                 475                 480 


Leu Asn Asn Phe Ser Ala Ala Val Cys Pro Pro Glu Asn Tyr Glu Lys 
                485                 490                 495     


Lys Asn Lys Glu Asp Val Leu Phe Met Gly Asp Lys Asp Leu Arg Glu 
            500                 505                 510         


Glu Met Tyr Pro Asn Ala Ser Trp His Ile Met Gln Tyr Phe Gly Gly 
        515                 520                 525             


Ile Ser Gln Trp Lys Asp Ser Cys Phe Glu Asp Ile Val Met Leu Glu 
    530                 535                 540                 


Asp Ala Asp Leu Asn Glu Glu Phe Val Leu Glu Val Lys Gly Ala Met 
545                 550                 555                 560 


Ser Leu Ile Arg Asn Ser Ala Phe His Tyr Ala Ala Ser Ala Ala Gln 
                565                 570                 575     


Gly Thr Leu Asp Lys Gly Ser Tyr Leu Val Glu Leu Phe Glu Arg Glu 
            580                 585                 590         


Arg Asp Asn Leu Gly Ser Lys Tyr Arg Lys Lys Tyr Val Ser Asn Asn 
        595                 600                 605             


Val Pro Met Phe Tyr Lys Val Glu Asp Ile Asp Arg Leu Met His Cys 
    610                 615                 620                 


Leu Tyr Gly Glu Gln Lys Val Leu Glu Ser Gln Ile Pro Ser Phe Arg 
625                 630                 635                 640 


Asn Val Ile Thr Arg Lys Ser Leu Pro Asp Ile Ile Val Lys Phe Val 
                645                 650                 655     


Lys Gly Lys Pro Tyr Gly Lys Ile Gln Lys Asn Val Glu Thr Ala Ser 
            660                 665                 670         


Lys Phe His Ser Ala Leu Tyr Phe Val Leu Lys Glu Ile Tyr Tyr Asn 
        675                 680                 685             


Gly Phe Leu Gln Glu Glu Asn Leu Met Glu Arg Phe Met Val Ser Phe 
    690                 695                 700                 


Asn Asn Glu Trp Asn Lys Val Lys Glu Ser Ser Gly Asn Lys Lys Lys 
705                 710                 715                 720 


Glu Ala Ala Met Lys Asp Phe Ser Arg Arg Ile Ser Glu Leu Gln Gln 
                725                 730                 735     


Asn Gly Lys Arg Leu Thr Phe Gly Glu Leu Cys Gln Ala Ile Met Thr 
            740                 745                 750         


Asp Tyr Asn Met Gln Asn Asn Gln Lys Lys Val Arg Leu Asn Lys Lys 
        755                 760                 765             


Asp Asn Leu Pro Asp Glu Lys Tyr Lys His Phe Lys Met Leu Leu Leu 
    770                 775                 780                 


Val Cys Leu Arg Glu Thr Phe Ile Asp Tyr Leu Lys Lys Asp Val Ala 
785                 790                 795                 800 


Gly Glu Lys Phe Asp Cys Ala Phe Leu Arg Glu Pro Gly Leu Lys Glu 
                805                 810                 815     


Asn Val Tyr Glu Asn Leu Thr Glu Glu Gln Phe Cys Lys Gly Trp Lys 
            820                 825                 830         


Ile Asp Arg Tyr Lys Asn Leu Ile Asn Glu Asn Gly Gln Tyr Asp Ser 
        835                 840                 845             


Trp Leu Ile Ser Trp Phe Ile Leu Ala His Phe Met Thr Pro Lys His 
    850                 855                 860                 


Leu Asn His Leu Cys Gly Glu Ile Lys Ser Tyr Leu Ser Tyr Val His 
865                 870                 875                 880 


Asn Ile Glu Arg Arg Arg Phe Asp Ala Met Arg Val Gln Val Glu Glu 
                885                 890                 895     


Asn Lys Glu Lys Arg Gln Lys Tyr Glu Gln Val Leu Glu Ile Leu Asn 
            900                 905                 910         


Leu Ala Ala Glu Tyr Cys Gly Gln Val Ser Asn Glu Arg Thr Asp Tyr 
        915                 920                 925             


Tyr Glu Ser Glu Glu Glu Tyr Ala Arg His Ile Ser Met Tyr Val Ala 
    930                 935                 940                 


Phe Glu Glu Lys Asn Ser Glu Arg Pro Leu Glu Glu Gln Leu Tyr Gly 
945                 950                 955                 960 


Phe Cys Asn Gln Lys Ala Asp Gly Gly Pro Ala Ser Arg Ile Gly Ile 
                965                 970                 975     


Phe Tyr Asp Gly Glu Asn Pro Ile Leu Asn Arg Asn Val Val Leu Thr 
            980                 985                 990         


Lys Leu Tyr Gly Ala Glu Arg Leu  Leu Ser Glu Cys Leu  Gln Lys Glu 
        995                 1000                 1005             


Arg Val  Thr Lys Ala Glu Ile  Glu Lys His Tyr Lys  His Thr Lys 
    1010                 1015                 1020             


Lys Leu  Glu Ala Val Phe Lys  Tyr Gly Thr Cys Lys  Asn Gln Glu 
    1025                 1030                 1035             


Gln Glu  Gln Glu Arg Arg Thr  Tyr Gln Gln Gln Lys  Asn Arg Ile 
    1040                 1045                 1050             


Glu Leu  Val Asp Ile Leu Lys  Tyr Ser Asp Leu Leu  Asn Asp Phe 
    1055                 1060                 1065             


Met Ser  Gln Leu Ile Ser Trp  Cys Tyr Leu Arg Glu  Arg Asp Arg 
    1070                 1075                 1080             


Met Tyr  Phe Gln Ile Gly Leu  His Tyr Ile Arg Leu  Tyr Tyr Gly 
    1085                 1090                 1095             


Glu Asn  Leu Val Glu Lys Asn  Ser Lys Phe Arg Val  Leu Gln Ser 
    1100                 1105                 1110             


Lys Glu  Ala Lys Ala Gly Glu  Lys Lys Gly Ile Asn  Leu Val Asp 
    1115                 1120                 1125             


Gly Ala  Val Leu Tyr Gln Ile  Ala Ala Ile Tyr Thr  Tyr Glu Tyr 
    1130                 1135                 1140             


Pro Val  Tyr Ala Leu Asp Glu  Ala Gly Asn Ala Ile  Val Ser Lys 
    1145                 1150                 1155             


Ala Ala  Lys Ile Gly Ser Thr  Thr Ala Asn Gly Ile  Asn Ala Phe 
    1160                 1165                 1170             


Trp Lys  Glu Tyr Cys Asn Glu  Asp Ala Ser Thr Tyr  Glu Val Gly 
    1175                 1180                 1185             


Leu Ser  Leu Phe Glu Asn Pro  Leu Glu Glu Lys Glu  Leu Ile Glu 
    1190                 1195                 1200             


Phe Arg  Asn Tyr Ile Asp His  Phe Lys Tyr Tyr Ser  Arg Arg Asp 
    1205                 1210                 1215             


Arg Ser  Ile Leu Asn Leu Tyr  Ser Gln Val Phe Ala  Asn Tyr Phe 
    1220                 1225                 1230             


Arg His  Asp Arg Lys Leu Lys  Lys Ser Val Thr Phe  Ile Leu Lys 
    1235                 1240                 1245             


Asn Ile  Leu Ala Arg His Phe  Ile Ile Ala Arg Thr  Val Leu Ala 
    1250                 1255                 1260             


Glu Val  Glu Val Glu Lys Lys  Asp Gly Arg Lys Asp  Lys Lys Asn 
    1265                 1270                 1275             


Pro Ile  Ile Arg Lys Tyr Ser  Gln Thr Glu Ile Arg  Ile Pro Thr 
    1280                 1285                 1290             


Glu Asn  Gly Leu Gln Ser Asp  Asp Thr Leu His Lys  Tyr Thr Lys 
    1295                 1300                 1305             


Glu Asp  Val Asp Asn Glu Tyr  Lys Lys Lys Met Asn  Asn Ser Lys 
    1310                 1315                 1320             


Gly Glu  Lys Gly Lys Ile Pro  Pro Lys Glu Gly Gly  Lys Tyr Ser 
    1325                 1330                 1335             


Ile Pro  Met Tyr Asp Glu Lys  Phe Ile Gln Arg Leu  Tyr Cys Ile 
    1340                 1345                 1350             


Leu Asn  Tyr Ala Lys 
    1355             


<210>  274
<211>  1391
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  274

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Lys Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn Gln Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Glu 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Ile Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Asn Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Val Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Phe Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Gln Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Met Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Cys Ile  Ser Ser Ile Lys Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Thr Leu Ile Thr Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Gly  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Gly Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Asn Lys Asn Lys Lys  Asn Lys Lys Asn Asn  Gly Asn Arg 
    1355                 1360                 1365             


Asp Glu  Lys Lys Asn Ser Asp  Gly Leu Thr Tyr Ser  Pro Phe Phe 
    1370                 1375                 1380             


Asp Leu  Pro Phe Glu Leu Pro  Glu 
    1385                 1390     


<210>  275
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  275

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Gly Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn Tyr Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Gly Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Gly Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Ser Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  276
<211>  1380
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  276

Met Lys Leu Ser Lys Glu Lys Gln Ile Arg Ser Ala Val Ala Asn Lys 
1               5                   10                  15      


Glu Lys Asn Thr Glu Gly Val Leu Tyr Arg Phe Pro Gly Ala Asp Ile 
            20                  25                  30          


Gly Gly Val Gln Ala Gln Met Leu Val Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Leu Gly Asn Lys Pro Lys Glu 
    50                  55                  60                  


Trp Met Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Lys Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Ala Ile Asn Asp Ile Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Lys Glu Ala Asp Lys Lys Ile Arg Asn Met Ser Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Asn Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Gly Asn Gln Glu Phe Asp Ser Ile Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp Arg 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Asp Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Ser Ile Gln Asp Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Ile Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Glu Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Ala Glu Lys Asp Gly Leu Asn Glu Phe Met Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Glu Glu Lys Arg Ala Glu Val Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Ser His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Val Asn Lys Glu Lys Phe Tyr Val Trp 
305                 310                 315                 320 


Lys Lys His Glu Cys Gly Lys Lys Glu Asn Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Val Glu Ala Glu Ala Glu Ser Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Ile Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Thr Gly Thr Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Lys Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asn Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Gln Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Leu 
            660                 665                 670         


Phe Arg Thr Val Phe Pro Glu Tyr Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Asn Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Arg Thr Leu Arg Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Lys 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Glu Asn Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Cys Ala Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu 
        915                 920                 925             


Leu Ser Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Lys Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Lys Phe Ser Glu Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Thr Asn Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Gly  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Glu Lys Pro Glu  Glu Tyr Glu Lys Ile  Glu Ala Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Ile  Tyr Ala Pro Glu Lys  Asn Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Gln Gly Arg Val Gly  Ala Lys Val 
    1145                 1150                 1155             


Thr Ser  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Glu Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Met Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Val Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Val Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Asp  Asp Glu Asp Ala Asp  Thr Lys Lys Pro Val  Ile Val Thr 
    1310                 1315                 1320             


Asn Val  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Glu  Asp Glu Asp 
    1325                 1330                 1335             


Lys Gln  Lys Gly Lys Glu Asn  Arg Gly Lys Lys Asn  Thr Glu Thr 
    1340                 1345                 1350             


Arg Ser  Asp Ala Glu Lys Asn  Asn Asn Asp Arg Leu  Ser Tyr Asn 
    1355                 1360                 1365             


Pro Phe  Ala Asn Phe Asp Phe  Lys Leu Pro Asn Lys  
    1370                 1375                 1380 


<210>  277
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  277

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Ile Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Phe Asp Phe Lys Leu  Leu Asn 
    1400                 1405                 1410         


<210>  278
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  278

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Pro Gly Thr Asp Thr 
            20                  25                  30          


Ile Asp Leu Lys Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Lys Val Phe Asn Gln Ile Gln Val Gly Asn Lys Pro Lys Lys 
    50                  55                  60                  


Trp Lys Lys Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Glu Tyr Val Glu Ser Ser Gln Arg Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Asp Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Glu Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Gly Leu Phe Val Asn Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Ile Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Ser Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Tyr Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Lys Asp Arg Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Lys Glu Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Gln Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Phe 
            660                 665                 670         


Ile Arg Lys Asn Phe Pro Glu Asp Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Lys Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Tyr 
                805                 810                 815     


Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Thr 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Asp Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Asp Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asn  Ser Glu Lys Lys Glu  Ala Tyr Gln Lys Ile  Glu Val Asn 
    1100                 1105                 1110             


Gly Asp  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Val  Tyr Ala Pro Asp Glu  Lys Gly Asp 
    1130                 1135                 1140             


Ile Leu  Lys Glu Gln Cys Thr  Lys Gly Gly Ala Gly  Gly Lys Ile 
    1145                 1150                 1155             


Ser Ala  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Lys Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Lys Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Lys Gln 
    1250                 1255                 1260             


Thr Thr  Ser Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Ser Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Lys  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Val Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Gly Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Pro Asn 
    1370                 1375                 1380         


<210>  279
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  279

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Thr Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Gly Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Lys Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Glu 
        755                 760                 765             


Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Lys Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1400                 1405                 1410         


<210>  280
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  280

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Ile Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Phe Asp Phe Lys Leu  Leu Asn 
    1400                 1405                 1410         


<210>  281
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  281

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Leu Tyr Gln Ile Val  Ser Ala Phe Asn Phe  Gly Ser Lys 
    1205                 1210                 1215             


Leu Leu  Tyr Ile Ser Glu Asp  Gly Arg Trp Lys Met  Ala Gly Gly 
    1220                 1225                 1230             


Ala Phe  Pro Gly Lys Tyr Gly  Arg Phe Glu Asn Asp  Tyr Asn His 
    1235                 1240                 1245             


Arg Thr  Ser Leu Ser Lys Val  Ile Arg Leu Phe Glu  Asn Glu Ser 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ile Ile Tyr  Trp Arg Asp Tyr Val  Asp His Met 
    1265                 1270                 1275             


Lys Tyr  Tyr Val Asn Gln Asn  Gln Ser Ile Met Glu  Ile Tyr Ser 
    1280                 1285                 1290             


Ala Phe  Tyr Ser Lys Val Leu  Gly Tyr Ser Ala Lys  Leu Arg Lys 
    1295                 1300                 1305             


Ser Val  Val Phe Asn Leu Gln  Ala Ala Leu Glu Lys  His His Ile 
    1310                 1315                 1320             


Asn Pro  Glu Cys Ile Trp Met  Thr Ser Asp Gly Lys  Cys Ala Asp 
    1325                 1330                 1335             


Ile Lys  Leu Met Lys Asn Leu  Glu Ser Gln Lys Phe  Thr Tyr Lys 
    1340                 1345                 1350             


Leu Ala  Lys Arg Glu Gly Glu  Lys Thr Glu Arg Lys  Ile Cys Met 
    1355                 1360                 1365             


Asn Ala  Leu Asn Glu Asn Phe  Leu Lys Thr Ile Arg  Thr Ser Leu 
    1370                 1375                 1380             


Glu Tyr  Lys Lys 
    1385         


<210>  282
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  282

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Lys Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Phe Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn Gln Ile Gln Thr Gly Thr Lys Pro Lys Glu Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Lys Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Asn Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Gly Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Gln Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Val Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Leu 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Tyr Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Met Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Ala Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Ser Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asn 
785                 790                 795                 800 


Ser Ile Phe Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Val Ala Asn Ala Phe Ala Leu Tyr Leu Gln Asn Asn Lys Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asp Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Asp Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asn Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Met Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Glu  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Ala Gln Gly  Gly Ala Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Arg Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Lys Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Met Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Cys Ile  Ser Ser Ile Lys Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Thr Leu Ile Thr Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Ser Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Trp Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asp Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  283
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  283

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  284
<211>  1366
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  284

Met Lys Leu Ser Lys Glu Asn His Ile Arg Ser Ala Val Val Ile Ser 
1               5                   10                  15      


Gly Lys Glu Gly Asn Ile Ala Gly Thr Leu Tyr Lys Ile Pro Gly Glu 
            20                  25                  30          


Gly Thr Val Asp Leu Lys Lys Trp Met Leu Glu Arg Asp Lys Ala Val 
        35                  40                  45              


Lys Ser Leu Tyr Asn Ile Phe Asn Gln Ile Gln Leu Gly Asn Glu Pro 
    50                  55                  60                  


Lys Glu Trp Lys Glu Asn Arg Asn Leu Ser Thr Glu Glu Asn Thr Arg 
65                  70                  75                  80  


Arg Met His Gln Lys Lys Val Lys Ile Gln Asn Tyr Lys Met Lys Lys 
                85                  90                  95      


Ala Cys Ser Arg Tyr Val Asn Thr Ile Ser Arg Thr Ile Asn Glu Leu 
            100                 105                 110         


Leu Phe Phe Tyr Lys Thr Thr Lys Thr Thr Gln Asn Asn Lys Val Lys 
        115                 120                 125             


Tyr Asp Lys Leu Lys Met Met His Lys Asn Glu Asp Ile Ile Ser Lys 
    130                 135                 140                 


Met Lys Asn Glu Asn Ile Leu Gln Gln Phe Lys Val Glu Gly Lys Asn 
145                 150                 155                 160 


Gly Lys Leu Glu Lys Gly Lys Leu Glu Asp Phe Val Thr Leu Ala Leu 
                165                 170                 175     


Arg Ser Ser Leu Val Val Ser Arg Tyr Lys Gly Lys Asp Phe Asp Ser 
            180                 185                 190         


Val Ala Ala Val Ala Val Phe Leu Glu Asn Ile Gly Asn Asn Asn Ile 
        195                 200                 205             


Ser His Glu Asp Glu Arg Thr Ile Asn Ile Leu Leu Asp Leu Ile Arg 
    210                 215                 220                 


Glu Asp Phe Thr Lys Leu Asn Pro Asn Ile Asp Asn Thr Met Gly Ala 
225                 230                 235                 240 


Arg Leu Ile Arg Ser Val Thr Asn Gln Asn Met Leu Val Gln Pro Gln 
                245                 250                 255     


Asn Asp Arg Phe Ser Phe Pro Cys Val His Asp Ser Gly Lys Ser Lys 
            260                 265                 270         


Val Ser Asn Lys Asn Val Glu Lys Ser Gly Leu Asp Asn Phe Leu Leu 
        275                 280                 285             


Asp Tyr Ala Asn Leu Asp Lys Asp Ile Arg Glu Asn Tyr Leu Arg Lys 
    290                 295                 300                 


Leu Arg Arg Ile Ile Asp Ile Tyr Phe Ser Ala Pro Ile Thr Tyr Gln 
305                 310                 315                 320 


Lys Asp Met Asp Val Ala Leu Ser Glu Val Val Val Lys Asp Lys Phe 
                325                 330                 335     


Asp Val Trp Lys Lys His Asn Glu Gly Lys Lys Asp Asn Asn Thr Phe 
            340                 345                 350         


Val Lys Val Pro Glu Val Leu Ile Lys Ala Glu Thr Asp His Glu Lys 
        355                 360                 365             


Leu Asp Thr Val Ile Glu Lys Gln Ala Arg Lys Glu Leu Ala Asp Arg 
    370                 375                 380                 


Val Arg Glu Gln Asn Met Thr Cys Tyr Arg Tyr Thr Gln Ala Val Val 
385                 390                 395                 400 


Lys Lys Tyr Asn Ala Lys Glu Ala Leu Phe Phe Glu Asn Asp Asp Ile 
                405                 410                 415     


Asn Gln Tyr Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu 
            420                 425                 430         


Lys Ser Cys Lys Ile Gly Thr Leu Phe Lys Leu His Asn Gly Tyr Leu 
        435                 440                 445             


Ile Glu Lys Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr 
    450                 455                 460                 


Ile Ala Leu Gly Lys Val Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp 
465                 470                 475                 480 


Asn Asp Asn Lys Val Lys Arg Leu Gly Asp Ile Ser Glu Lys Ile Arg 
                485                 490                 495     


Ser Gly Ile Thr Ser Phe Asp Tyr Glu Met Leu Lys Ala Gln Glu Thr 
            500                 505                 510         


Leu Gln Arg Glu Leu Ala Val Asn Val Ala Phe Ser Ala Asn Asn Leu 
        515                 520                 525             


Ala Arg Ala Val Cys Asn Met Ser Ala Leu Ser Asp Lys Thr Ser Asp 
    530                 535                 540                 


Phe Leu Leu Trp Gln Pro Asp Asp Ile Asn Asn Lys Met Lys Lys Ser 
545                 550                 555                 560 


Thr Gly Asn Asp Glu Asp Asn Glu Lys Asn Lys Arg Ala Val Cys Ala 
                565                 570                 575     


Val Leu Gln Phe Phe Gly Gly Lys Ser Leu Trp Asn Asp Val Asp Phe 
            580                 585                 590         


Glu Lys Ala Tyr Lys Asn Ala Gly Lys His Gly Tyr Gly Val Tyr Phe 
        595                 600                 605             


Ile Asn Asp Leu Arg Lys Ala Ile Phe Ala Ala Arg Asn Glu Ser Phe 
    610                 615                 620                 


His Phe Lys Thr Ala Ser Val Asn Asn Glu Lys Trp Asn Val Glu Phe 
625                 630                 635                 640 


Leu Gly Arg Met Phe Glu Lys Glu Thr Glu Phe Cys Leu Asp Ile Glu 
                645                 650                 655     


Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Met Phe Tyr Lys Ser Ser 
            660                 665                 670         


Asn Leu Glu Lys Met Leu Asn His Phe Tyr Ser Lys Asn Ile Ser Arg 
        675                 680                 685             


Ala Ala Gln Val Leu Ser Tyr Asn Thr Val Phe Val Arg Lys Thr Phe 
    690                 695                 700                 


Pro Glu Tyr Val Asn Asn Val Leu Lys Tyr Lys Lys Pro Gly Thr Asp 
705                 710                 715                 720 


Ala Glu Ile Leu Asp Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu Leu Lys 
                725                 730                 735     


Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Lys Asp Ala Phe Lys Tyr 
            740                 745                 750         


Phe Glu Asn Ala Val Tyr Asn Leu Asn Ser Lys Asn Ile Asn His Asp 
        755                 760                 765             


Ser Ser Gly Gln Lys Leu Ser Arg Asp Glu Met Lys Arg Lys Lys Ala 
    770                 775                 780                 


Ala Glu Ser Phe Gln Arg Arg Phe Val Glu Ile Lys Arg Val Ser Asp 
785                 790                 795                 800 


Ser Ser Ile Ser Tyr Val Cys Gln Val Phe Met Thr Asp Tyr Asn Gln 
                805                 810                 815     


Gln Asn Asn Gln Asn Lys Lys Val Arg Ser Ser Asn Asp Ser Leu Leu 
            820                 825                 830         


Asp Lys Pro Ile Tyr Gln His Phe Lys Met Leu Leu Lys Glu Thr Ile 
        835                 840                 845             


Lys Ser Ala Phe Ala Ala Tyr Leu Lys Asp Asn Asn Asn Lys Asp Leu 
    850                 855                 860                 


Phe Gly Phe Ile Gly Glu Pro Leu Lys Ile Asn Lys Asn Asp Asp Val 
865                 870                 875                 880 


Lys Val Ile Lys Lys Glu Glu Phe Leu Pro Asp Trp Lys Ser Glu Lys 
                885                 890                 895     


Tyr Ser Leu Leu Ile Glu Lys Val Lys Lys Ser Pro Lys Leu Gln Met 
            900                 905                 910         


Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met 
        915                 920                 925             


Ala Gly Ser Met Arg Ser Tyr Leu Gln Tyr Val Ser Asp Ile Asn Arg 
    930                 935                 940                 


Arg Ala Asn Val Val Gly Asn Lys Leu His Val Glu Val Leu Asp Lys 
945                 950                 955                 960 


Asp Thr Val Lys Asp Trp Ile Gln Val Ile Glu Val Cys Leu Leu Leu 
                965                 970                 975     


Ala Ser Arg Thr Ser Asn Gln Phe Asp Asp Tyr Phe Asn Asp Gly Asp 
            980                 985                 990         


Asp Tyr Ala Gly Tyr Leu Lys Ser  Tyr Val Asp Phe Ser  Asp Lys Asn 
        995                 1000                 1005             


Met Pro  Ser Ala Tyr Ser Ala  Leu Val Tyr Phe Ser  Asp Gln Gly 
    1010                 1015                 1020             


Lys Ile  Asp Leu Tyr Ile Asp  Pro Lys Asn Pro Lys  Ile Asn Arg 
    1025                 1030                 1035             


Asn Ile  Val Gln Ser Lys Leu  Phe Ala Ala Asp His  Ile Leu Gly 
    1040                 1045                 1050             


Asn Gly  Gln Ile Val Gln Pro  Val Ser Lys Asp Asp  Ile Ala Glu 
    1055                 1060                 1065             


Phe Tyr  Asn Leu Lys Ala Lys  Ile Ala Asp Ser Lys  Ile Lys Gly 
    1070                 1075                 1080             


Glu Asn  Ile Ser Glu Lys Glu  Gln Arg Asn Ile Leu  Arg Tyr Gln 
    1085                 1090                 1095             


Arg Leu  Lys Asn Lys Val Glu  Leu Arg Asp Ile Val  Glu Tyr Gly 
    1100                 1105                 1110             


Glu Ile  Ile Asn Glu Leu Leu  Gly Gln Leu Ile Asn  Trp Ser Phe 
    1115                 1120                 1125             


Met Arg  Glu Arg Asp Leu Leu  Tyr Phe Gln Leu Gly  Phe His Tyr 
    1130                 1135                 1140             


Asn Cys  Leu Arg Asn Asn Ser  Glu Lys Pro Glu Glu  Tyr Lys Lys 
    1145                 1150                 1155             


Ile Glu  Ala Asp Asp Ile Ser  Ile Asn Asp Ala Val  Leu Tyr Gln 
    1160                 1165                 1170             


Ile Ile  Gly Met Tyr Val Asn  Gly Ile Pro Val Tyr  Thr Ser Asp 
    1175                 1180                 1185             


Asn Asn  Lys Leu Lys Gly Glu  Cys Ala Asn Gly Gly  Ala Gly Gly 
    1190                 1195                 1200             


Lys Ile  Thr Ala Phe Cys Glu  Tyr Ser Glu Tyr Leu  Gly Phe Lys 
    1205                 1210                 1215             


Lys Ala  Thr Leu Tyr Glu Ser  Gly Leu Glu Leu Phe  Glu Val Leu 
    1220                 1225                 1230             


Ala Glu  His Asp Asp Ile Ile  Lys Leu Arg Asn Gly  Ile Glu His 
    1235                 1240                 1245             


Phe Lys  Tyr Tyr Leu Gly Asn  Tyr Arg Ser Ile Met  Ser Leu Tyr 
    1250                 1255                 1260             


Ser Glu  Val Phe Asp Arg Phe  Phe Thr Tyr Asp Leu  Lys Tyr Gln 
    1265                 1270                 1275             


Lys Asn  Val Leu Asn Leu Leu  Gln Asn Ile Leu Leu  Arg His Asn 
    1280                 1285                 1290             


Ile Val  Ile Val Pro Glu Phe  Glu Ser Gly Thr Lys  Lys Val Gly 
    1295                 1300                 1305             


Lys Asn  Ile Lys Gln Ser Ala  Lys Ile Ser Ile Lys  Asn Ile Gln 
    1310                 1315                 1320             


Ser Asp  Lys Phe Thr Tyr Lys  Ile Lys Gly Gly Thr  Thr Ser Ile 
    1325                 1330                 1335             


Asp Ala  Lys Asp Asp Arg Tyr  Leu Glu Thr Ile Lys  Lys Ile Leu 
    1340                 1345                 1350             


Tyr Tyr  Pro Glu Tyr Asp Lys  Asp Ser Gly Gly Val  Cys 
    1355                 1360                 1365     


<210>  285
<211>  1476
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  285

Met Lys Ile Thr Lys Val Arg Val Lys Glu Asn Asn Glu Arg Tyr Ser 
1               5                   10                  15      


Ala Gln His Tyr Arg Asn Val Tyr Asn Gly Met Leu His Lys Val Ser 
            20                  25                  30          


Asn Asn Glu Phe Val Asp Thr Gly Lys His Leu Asp Asn Ile Asn Asn 
        35                  40                  45              


Ser Thr Lys Ala Leu Asp Lys Ser Phe Ile Asp Arg Leu Val Val Pro 
    50                  55                  60                  


Lys Glu Ser Lys Asn Tyr Asp Ser Ala Val His Asn Phe Leu Gln Lys 
65                  70                  75                  80  


Ile Phe Lys Asp Lys Lys Ile Gly Asp Ala Lys Glu Lys Phe Ile Gln 
                85                  90                  95      


Asn Leu Asn Gly Asn Thr Lys Lys Tyr Lys Ala Cys Leu Ser Leu Ser 
            100                 105                 110         


Asp Glu Gly Gln Lys Phe Cys Asn Gly Lys Leu Lys Glu Ile Val Gly 
        115                 120                 125             


Lys Val Ala Ser Asn Asn Ile Phe Tyr Lys Asp Thr Gly Asn Ile Asp 
    130                 135                 140                 


Asn Ser Ile Asn Lys Met Leu Glu Lys Ile Gln Asn Ser Met Asn Pro 
145                 150                 155                 160 


Glu Asn Gly Phe Asn Ile Asp Lys Leu Ile Val Pro Arg Asp Asp Ala 
                165                 170                 175     


Asn Tyr Asn Asp Lys Val Tyr Phe Phe Ile Gln Asp Val Lys Asn Asp 
            180                 185                 190         


Lys Asp Ser Val Lys Gln Asn Leu Glu Ser Tyr Gln Leu Val Glu Lys 
        195                 200                 205             


Met Thr Asp Asp Asp Leu Leu Asn Lys Ala Tyr Met Ala Leu Ser Ser 
    210                 215                 220                 


Lys Gly Lys Ala Phe Phe Thr Lys Glu Glu Arg Lys Ile Ile Phe Glu 
225                 230                 235                 240 


Asn Ile Ile Thr Gly Gln Lys Ile Thr Ala Asp Asp Glu Lys Lys Ile 
                245                 250                 255     


Ile Thr Asp Met Gln Ser Val Ala Ser Asp His Lys Glu Gln Ile Arg 
            260                 265                 270         


Lys Ser Ile Ile Asn Asn Asn Ile Asn Val Asp Pro Ser Ser Arg Leu 
        275                 280                 285             


Arg Gln Tyr Phe Ile Asn Ser Phe Val Val Ser Lys Asp Asp Val Asn 
    290                 295                 300                 


Tyr Asn Asp Arg Val His Asp Phe Ile His Lys Leu Cys Ile Ser Asn 
305                 310                 315                 320 


Ile Asp Ile Ser Lys Leu Lys Lys Tyr Pro Leu Lys Asn Val Ala Thr 
                325                 330                 335     


Glu Gln Asp Val Gln Gln Thr Leu Ser Ala Glu Gly Arg Ala Phe Cys 
            340                 345                 350         


Asp Gly Lys Leu Ser Lys Val Ile Thr Ala Phe Ala Thr Asn Asp Ile 
        355                 360                 365             


Lys Gly Ile Thr Gln Asn Asp Leu Gly Cys Ile Lys Gln Lys Ile Asn 
    370                 375                 380                 


Glu Ala Thr Leu Ser Ser Ile Ser Glu Asp Asn Ala Asn Leu Tyr Glu 
385                 390                 395                 400 


Arg Tyr Ser Asp Tyr Asn Asn Gly Asn Pro Asn Cys Ser Arg Asn Ile 
                405                 410                 415     


Phe Glu Lys Asn Ile Asn Glu Asn Tyr Asn Gln Lys Arg Leu Ser His 
            420                 425                 430         


Gly Glu Trp Leu Val Gln Phe Ile Ala Asn Asn Ser Ile Asn Asp Glu 
        435                 440                 445             


Arg Phe Lys Thr Phe Glu Arg Leu Phe Gln Tyr Asp Glu Leu Ser Cys 
    450                 455                 460                 


Lys Leu Thr Glu Cys Leu Lys Lys Tyr Lys Thr Glu Leu Asn Lys Leu 
465                 470                 475                 480 


Asn Ser Ile Glu Glu Gly Asp Lys Glu Gly Gln Lys Gln Ile Arg Gln 
                485                 490                 495     


Tyr Lys Lys Asp Cys Leu Ile Glu Ile His Asp Ile Tyr Lys Gln His 
            500                 505                 510         


Glu Val Lys His Tyr Lys Asp Lys Glu Gly Glu Ser Thr Lys Lys His 
        515                 520                 525             


Glu Met Tyr Phe Ala Tyr Tyr Ile Arg Glu Val Arg Glu Tyr Phe Asn 
    530                 535                 540                 


His Tyr Phe Pro Leu Gln Asn Asn Thr Arg Lys Gln Ser Ile Asn Lys 
545                 550                 555                 560 


Arg Asp Ile Thr Asn Phe Ile Thr Tyr Ile Asp Lys Tyr Ala Asn Ile 
                565                 570                 575     


Glu Lys Ile Lys Thr Ile Val Lys Tyr Gln Ile Leu Asn Lys Leu Thr 
            580                 585                 590         


Ser Gln Leu Ile Leu Glu Gly Lys Leu Ala Tyr Phe Ser Asp Ser Phe 
        595                 600                 605             


Asp Gln Phe Thr Ser Asp Asp Leu Glu Leu Ile His Val Gln Glu Ala 
    610                 615                 620                 


Phe Lys Lys Gln Leu Met Thr Ser Ile Leu Trp Ala Thr Asn Arg Leu 
625                 630                 635                 640 


Arg Phe Ile Met Leu Gly Glu Gln Asp Thr Ala Gln Leu Gly Asp Ile 
                645                 650                 655     


Leu Leu Gln Gly Asn Phe Asp Lys Ala Leu Asp Met Val Lys Ser Asn 
            660                 665                 670         


Lys Cys Glu Thr Ile Lys Lys Leu Lys Trp Phe Leu Asn Gly Ile Asp 
        675                 680                 685             


Gly Thr Asn Asp Thr Asp Asp Thr Asp Asp Lys Thr Ser Val Leu Leu 
    690                 695                 700                 


Thr Asn Ile His Asn Ala Ile Tyr Tyr Thr His Arg Asn Asn Ile Tyr 
705                 710                 715                 720 


His Phe Ser Lys Glu Tyr Phe Leu Glu Asp Lys Asn Phe Tyr Ile Asp 
                725                 730                 735     


Gly Asn Asp Gln Leu Thr Lys Asp Leu Tyr Asp Asn Asp Lys Asp Ser 
            740                 745                 750         


Val Lys Val Ala Phe Lys Glu Lys Ile Arg Ser Met Asn Leu Tyr Thr 
        755                 760                 765             


Cys Tyr Pro Ser Glu Val His Ser Ala Ile Leu Gly Lys Ile Ser Phe 
    770                 775                 780                 


Ser Leu Ser His Pro Asn Ile Ser Ile Ile Pro Ser Phe Lys Asn Val 
785                 790                 795                 800 


Tyr Asn Lys Gly Lys Ser Leu Gln Asn Gly Asn Asp Gly Ala Lys Arg 
                805                 810                 815     


Ser Gln Gly Lys Gly Ile Gln Gly Leu Glu Trp Phe Val Leu Pro Ala 
            820                 825                 830         


Glu Asp Glu Lys Lys Leu Leu Asn Ser Ser Glu Glu Val Arg Val Tyr 
        835                 840                 845             


Arg Asn Phe Leu Gln Leu Ile Tyr Glu Tyr Glu Phe Leu Pro Ser Ile 
    850                 855                 860                 


Tyr Glu Phe Leu Pro Ser Ile Asn Lys Thr Glu Ile Thr Asn Leu Glu 
865                 870                 875                 880 


Gly Leu His Glu Ser Ala Ile Glu Leu Asn Lys Glu Ser Ala Lys Lys 
                885                 890                 895     


Arg Gln Val Glu Ala Lys Lys Pro Lys Ile Asn Asn Asn Glu Phe Lys 
            900                 905                 910         


Tyr Glu Ile Ile Glu Thr Phe Gly Asn Asp Phe Phe Lys Asn Ala Pro 
        915                 920                 925             


Gln Gly Glu Phe Ser Lys Glu Asp Cys Glu Glu Tyr Phe Arg Lys Leu 
    930                 935                 940                 


Gln Ser Leu Met Val Lys Lys Glu Asn Glu Asn Gln Glu Ser Lys Asp 
945                 950                 955                 960 


Lys Gly Thr Leu Lys Pro Gly Ser Asp Lys Asp Lys Asn Ile Tyr Val 
                965                 970                 975     


Asp Phe Val Arg Asp Leu Tyr Val Phe Ala Phe Asn Gln Phe Leu Glu 
            980                 985                 990         


Asn Asn Tyr Ser Gln Val Lys Asp  Gly Leu Thr His Pro  Gln Tyr Asn 
        995                 1000                 1005             


Lys Asp  Asn Glu Phe Glu Cys  Cys Glu Leu Lys Ile  Asp Ala Asp 
    1010                 1015                 1020             


Ser Leu  Pro Glu Gln Ala Pro  Gln Leu Tyr Leu Met  Ala Arg Leu 
    1025                 1030                 1035             


Leu Asp  Ala Asp Gln Leu Asn  Asp Leu Arg His Gln  Phe Ile Arg 
    1040                 1045                 1050             


Tyr Asn  Gly Ser Ile Lys Asp  Ile Tyr Lys Asp Glu  Lys Asp Ile 
    1055                 1060                 1065             


Ala Ser  Lys Val Lys Glu Ile  Ile Asp Ile Leu Thr  Met Val Asn 
    1070                 1075                 1080             


Leu Thr  Ser Val Asn Tyr Thr  Glu Asp Leu Lys Ile  Phe Leu Gly 
    1085                 1090                 1095             


Gly Asn  Asp Asp Ser Asn Gln  Lys Gln Gln Glu Lys  Cys Glu Glu 
    1100                 1105                 1110             


Leu Tyr  Lys Pro Phe Met Asn  Gly Asp Val Lys Lys  Leu Trp Gly 
    1115                 1120                 1125             


Glu Glu  Ser Ser Gln Asp Leu  Tyr Val Gln Gln Gly  Gly Thr Pro 
    1130                 1135                 1140             


Ile Leu  His Lys Gly Ile Gly  Val Ala Tyr Arg Ser  Gly Cys Phe 
    1145                 1150                 1155             


Asp Leu  Tyr Lys Val Leu Tyr  Ser Lys Ala Val Ser  Asn Lys Ile 
    1160                 1165                 1170             


Asn Lys  Lys Asp Cys Glu Asp  Tyr Leu Ala Tyr Asn  Asn Thr Asn 
    1175                 1180                 1185             


Glu Gly  Ala Ile Lys Ser Asn  Ile Glu Glu Ala Gln  Gln Asn Arg 
    1190                 1195                 1200             


Glu Glu  Leu His Lys Lys Ile  Val Glu Lys Glu Phe  Asn Asp Leu 
    1205                 1210                 1215             


Pro Tyr  Asp Tyr Lys Ile Ser  Asn Ile Asn Asp Tyr  Glu Ile Val 
    1220                 1225                 1230             


Ala Lys  Lys Val Asp Ser Tyr  Asn Lys Leu Arg Asn  Lys Val Thr 
    1235                 1240                 1245             


Phe Asn  Asp Leu Tyr Ser Leu  Gly Gln Leu His Arg  Asp Ile Leu 
    1250                 1255                 1260             


Ser Arg  Phe Ile Gly Phe Ala  Val Asp Trp Glu Arg  Asp Met His 
    1265                 1270                 1275             


Phe Leu  Leu Ile Ser Leu Thr  Lys Tyr Gly Leu Met  Lys Glu Ala 
    1280                 1285                 1290             


Lys Glu  Asn Pro Lys Tyr Ile  Asn Lys Thr Ile Val  Glu Phe Ile 
    1295                 1300                 1305             


Ser Asp  Lys Phe Phe Asn His  Glu Asn Gly Gly Ala  Ala Ser Asn 
    1310                 1315                 1320             


Ile Cys  Glu Glu Phe Arg Lys  Asn Glu Lys Leu Lys  Glu Leu Phe 
    1325                 1330                 1335             


Lys Glu  Leu Tyr Gln Ser Asn  Asn Ile Asp Ser Phe  Tyr Lys Met 
    1340                 1345                 1350             


Phe Asp  Ile Arg Asn Trp Val  Ala His Leu Asn His  Ile Gln Pro 
    1355                 1360                 1365             


Gly Ser  Lys Thr Asp Arg Ser  Leu Val Asp Ala Ile  Asn Asp Leu 
    1370                 1375                 1380             


Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Arg Lys Asn  Ala Val Thr 
    1385                 1390                 1395             


Lys Ala  Ile Ile Glu Met Met  Glu Lys Glu Lys Ile  Arg Leu Thr 
    1400                 1405                 1410             


Phe Glu  Ser Asp Cys Gly His  Asp Phe Lys Leu Tyr  Lys Val Glu 
    1415                 1420                 1425             


Ser Glu  Gln Ile Thr His Leu  Lys Lys Ile Ser Ile  Lys Gln Tyr 
    1430                 1435                 1440             


Lys Asn  Gly Lys Asn Gln Leu  Thr Ser Met Ser Phe  Asp Ile Pro 
    1445                 1450                 1455             


Ala Arg  Ser Glu Glu Phe Cys  Lys Leu Val Glu Gln  Leu Phe Asp 
    1460                 1465                 1470             


Trp Lys  Ala 
    1475     


<210>  286
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  286

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  287
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  287

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Asp Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Thr 
        115                 120                 125             


Lys Asp Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His 
            180                 185                 190         


Glu Arg Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Glu Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Arg 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Lys Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  288
<211>  1353
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  288

Met Lys Val Thr Lys Ala Glu Lys Leu Arg Val Ala Val Ser Arg Lys 
1               5                   10                  15      


Leu Asn Asn Glu Asp Lys Arg Ala Val Leu Tyr Lys Thr Pro Asn Pro 
            20                  25                  30          


Gly Gln Thr Cys Gly Thr Val Lys Lys Gln Leu Ala Asn Arg Val Glu 
        35                  40                  45              


Arg Ala Asn Lys Leu Tyr Gly Val Phe Phe Arg Ser Asp Val Pro Glu 
    50                  55                  60                  


Thr Leu Gln Tyr His Phe Glu Glu Leu Val Thr Tyr Ala Ala Gln Ser 
65                  70                  75                  80  


Thr Ser Pro Asn Glu Phe Arg Gln Lys Ala Ser Gln Tyr Arg Glu Cys 
                85                  90                  95      


Glu Lys Lys Asp Lys Phe Gly Lys Met Arg Lys Tyr Pro Ile Phe Arg 
            100                 105                 110         


Cys Ser Tyr Ala Pro Ser Gly Lys Asn Met Lys Lys Val Met Glu Leu 
        115                 120                 125             


Tyr Val Arg Glu Arg Met Lys Asp Glu Trp Gln Ser Gln Ala Tyr Arg 
    130                 135                 140                 


Thr Ala Ala Ile Glu Ile Leu Leu Cys Ile Cys Asn Lys Asp Phe Ser 
145                 150                 155                 160 


Lys Gln Leu Ser Arg Val Asp Ala Arg Ile Phe Ala Asp Phe Tyr Asn 
                165                 170                 175     


Ala Ser Lys Ala Cys Pro Gln Pro Tyr Ile Gly Lys Ser Thr Gly Val 
            180                 185                 190         


Leu Glu Ala Ala Phe Thr Ser Val Met Lys Gln Met Ser Leu His Ala 
        195                 200                 205             


Lys Ala Asn Ala Ser Asn Lys Ile Trp Trp Leu Gln Asn Gln Leu Arg 
    210                 215                 220                 


Thr Ile Glu Leu Asn Lys Lys Ile Val Lys Ile Ser Asp Phe Lys Tyr 
225                 230                 235                 240 


Glu Tyr Ala Thr Glu Asp Arg Met Arg Ala Ile Leu Val Arg Met Arg 
                245                 250                 255     


Lys Ser Leu Lys Arg Gly Thr Asn Gly Asp Ile Ala Val Ala Leu Leu 
            260                 265                 270         


Gln Gly Ile Ala Gln Met Asn Gly Lys Thr Leu Ser Gly Val Leu Glu 
        275                 280                 285             


Glu Leu Ser Ala Asn Ser Glu Thr Lys Glu Gln Leu Ile Lys Phe Leu 
    290                 295                 300                 


Lys Ala Val His Glu Asp Tyr His Lys Thr Pro Ile Leu Lys Ala Ile 
305                 310                 315                 320 


Arg Asn Gln Asp Val Lys Val Gln Val His Glu Val Asp Pro Val Ser 
                325                 330                 335     


Pro Glu Gly Arg Ala Leu Asp Leu Ala Ser Ile Asn Val Ser Lys Gly 
            340                 345                 350         


Asn Glu Arg Lys Lys Tyr Lys Val Ala Leu Thr Gln Thr Leu Gly Asn 
        355                 360                 365             


Tyr Ala Lys Ser Pro Lys Asp Ala Thr Gln Thr Leu Lys Ala Ile Lys 
    370                 375                 380                 


Gly Val Leu Leu Asp Tyr Phe Met Trp Leu Asp Ser Asp Val Lys Ala 
385                 390                 395                 400 


Glu Phe Leu Glu Asp Asn Asn Leu Trp Lys Ile Pro Asn Arg Thr Glu 
                405                 410                 415     


Glu Tyr Phe Asp Asn Asn Phe Val Pro Ile Asp Asp Lys Lys Asp Asp 
            420                 425                 430         


Lys Ile Glu Ala Ile Glu Asp Phe Ala Ser Ile Trp Arg Gln Glu Arg 
        435                 440                 445             


Val Lys Asn Ser Arg Ile Lys Ala Arg Met Asn Tyr Val Asn Cys Gly 
    450                 455                 460                 


Lys Tyr Gln Gln Leu Ile Lys Gln Glu Thr Asp Asp Phe Arg Ile Cys 
465                 470                 475                 480 


Trp Ile Ser Tyr Ala Lys Asp Phe Val Glu Lys Asn Tyr Val Ser Lys 
                485                 490                 495     


Asn Arg Gln Phe Thr Gln Gly Asp Cys Phe Ser Thr Lys Met Leu Leu 
            500                 505                 510         


Glu Cys Trp Lys Glu Ile Ile Arg Phe Ile Cys Gly Lys Tyr Ile Asp 
        515                 520                 525             


Ile Gly Lys Ala Val Tyr His Phe Ala Met Pro Glu Thr Met Asn Ala 
    530                 535                 540                 


Arg Asp Ser Leu Ala Tyr Gly Val Leu Gly Glu Lys Tyr Lys Glu Gly 
545                 550                 555                 560 


Ile Ser Ser Phe Asp Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln 
                565                 570                 575     


Arg Asp Ile Ala Lys Ala Ala Val Ala Ala Ile His Ala Phe Ser Gly 
            580                 585                 590         


Ser Val Ile Asp Asp Lys Lys Pro Val Glu Asp Ile Leu Phe Ile Lys 
        595                 600                 605             


Asp Glu Glu Leu Gln Glu His Ala Lys Ala Asp Asp Val Ile Val Lys 
    610                 615                 620                 


Gln Ile Leu Arg Phe Tyr Gly Gly Phe Ser Ser Val Glu Gly Arg Glu 
625                 630                 635                 640 


Lys Leu Glu Gly Met Ala Leu Ala Lys Glu Val Leu Ser Gln Leu Lys 
                645                 650                 655     


Ala Ile Arg Asn Glu Asn Phe His Phe Thr Gln Gly Lys Arg Lys Asn 
            660                 665                 670         


Val Glu Glu Asn Ile Pro Leu Thr Lys Ala Leu Trp Glu Asn Glu Glu 
        675                 680                 685             


Lys Val Tyr Arg Gln Thr Val Lys Glu Thr Tyr Tyr Ser Asn Asn Val 
    690                 695                 700                 


Ser Met Phe Tyr Ser Gln Glu Val Ile Gln Lys Leu Val Ala Glu Leu 
705                 710                 715                 720 


Tyr Gln Asn Asn Asn Val Ala Glu Ala Gln Ile Pro Ala Phe Arg Thr 
                725                 730                 735     


Ile Trp Lys Arg Lys Asp Leu Pro Glu Tyr Ile Gly Ser Leu Asn Ile 
            740                 745                 750         


Ser Trp Asp Lys Thr Glu Pro Lys Gln Val Ile Tyr Glu Gly Ala Leu 
        755                 760                 765             


Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Lys Ser Gly 
    770                 775                 780                 


Glu Ala Lys Lys Leu Phe Phe Asp Ala Val Met Asp Asn Ala Thr Glu 
785                 790                 795                 800 


Met Glu Lys Ser Ser Asn Ala Asp Ser Arg Asn Gln Glu Lys Lys Ala 
                805                 810                 815     


Leu Ala Asn Ala Gly Lys Asn Phe Arg Asp Tyr Val Asn Gly Leu Asn 
            820                 825                 830         


Ala Ser Thr Leu Gly Glu Val Cys Gln Phe Ile Gln Asn Glu Tyr Asn 
        835                 840                 845             


Gln Gln Asn Arg Gly Lys Gln Glu Gln Glu Ile Tyr Lys His Phe Lys 
    850                 855                 860                 


Met Leu Leu Pro Ile Cys Met Arg Lys Ala Phe Gln Arg Tyr Ile Asp 
865                 870                 875                 880 


Glu Lys His Ser Phe Ile Lys Lys Pro Gly Glu Leu Pro Gln Thr Thr 
                885                 890                 895     


Glu Asp Tyr Leu Glu Asn Val Lys Val Ala Cys Pro Glu Lys Lys Ile 
            900                 905                 910         


Lys Leu Gly Arg Trp Phe Thr Phe Ala His Phe Ile His Pro Arg Glu 
        915                 920                 925             


Leu Asn Phe Leu Ile Gly Asp Phe Lys Asn Tyr Ile Gln Tyr Arg Glu 
    930                 935                 940                 


Asp Val Leu Arg Arg Ser Glu His Ala Gly Gln Phe Ser Asp Thr Thr 
945                 950                 955                 960 


Glu Arg Asp Gly Glu Lys Ala Val Val Asp His Ala Val Gln Lys Ala 
                965                 970                 975     


Lys Asp Ile Leu Gly Val Leu Glu Phe Val Arg His Ile Ser Gly Arg 
            980                 985                 990         


Val Ser Asn Glu Phe Thr Asp Tyr  Tyr Ala Asp Arg Ala  Glu Tyr Asp 
        995                 1000                 1005             


Glu Tyr  Met Ala Lys Tyr Phe  Glu Pro Asp Val Gln  Ile Glu Gln 
    1010                 1015                 1020             


Tyr Asp  Leu Tyr Gly Asp Ala  Lys Asn Ala Lys Val  Ile Arg Asn 
    1025                 1030                 1035             


Ile Glu  Leu Ala Arg Met Tyr  Ala Gly Asp Ser Leu  Met Ser Ala 
    1040                 1045                 1050             


Ser Tyr  Arg Lys Ile Thr Lys  Lys Glu Ile Glu Thr  Tyr Tyr Ala 
    1055                 1060                 1065             


Lys Lys  Asp Glu Ile Ala Gln  Leu Gln Ser Gln Gly  Ile Cys Asn 
    1070                 1075                 1080             


Ser Lys  Lys Glu Gln Glu Asp  Ile Val Ala Phe Gln  Lys Leu Lys 
    1085                 1090                 1095             


Asn Arg  Ile Thr Leu Asn Glu  Val Thr Asp Leu Trp  Ser Leu Val 
    1100                 1105                 1110             


Asn Glu  Leu Leu Gly Asn Leu  Val Ser Leu Ala Tyr  Leu Arg Glu 
    1115                 1120                 1125             


Arg Asp  Glu Met Tyr Leu Phe  Leu Gly Phe Tyr Tyr  Met Ala Leu 
    1130                 1135                 1140             


Arg His  Pro Glu Gly Trp Thr  Asn Glu Ile Met Asn  Ser Val Ser 
    1145                 1150                 1155             


Asn Glu  Lys Tyr Ala Val Lys  Glu Gly Leu Val Leu  Tyr Gln Thr 
    1160                 1165                 1170             


Val Ala  Val Phe Asp Phe Gly  Thr Lys Leu Leu Phe  Gln Asn Asp 
    1175                 1180                 1185             


Asn Gln  Lys Trp Glu Glu Thr  Thr Gly Tyr Lys Trp  Gln His Phe 
    1190                 1195                 1200             


Ile Asp  Asn His Lys Glu Ser  Tyr Ala Cys Ile Leu  Pro Leu Phe 
    1205                 1210                 1215             


Glu Ile  Ala Lys Cys Glu Thr  Glu Ala Arg Ala Val  Arg Asn Tyr 
    1220                 1225                 1230             


Val Asp  His Phe Lys Tyr Tyr  Ser Asn Glu Asp Arg  Ser Ile Leu 
    1235                 1240                 1245             


Glu Leu  Tyr Gly Lys Phe Tyr  Thr His Leu Phe Gly  Tyr Ser Thr 
    1250                 1255                 1260             


Arg Leu  Arg Lys Ser Val Leu  Gln Ile Leu Ala Gln  Thr Leu Glu 
    1265                 1270                 1275             


Lys His  Gly Ile Ser Ala Gly  Ile Gln Phe Asp Gly  Thr Thr Val 
    1280                 1285                 1290             


Lys Ala  Thr Arg Cys Asp Met  Lys Ser Val Glu Phe  Thr Tyr Lys 
    1295                 1300                 1305             


Tyr Glu  Glu Lys Leu Asn Glu  Gln Lys Thr Val Leu  Arg Thr Ile 
    1310                 1315                 1320             


Ser Leu  Pro Ala Lys Ser Glu  Gly Phe Ile Thr Ala  Val Cys Glu 
    1325                 1330                 1335             


Met Leu  Lys Gln Lys Lys Gly  Asp His Thr Glu Asn  Thr Leu Cys 
    1340                 1345                 1350             


<210>  289
<211>  1357
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  289

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Pro Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Lys Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Asp Ile Gln Lys Ile Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Lys Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Cys Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Thr Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Phe 
                325                 330                 335     


Asn Gly Leu Glu Glu Leu Glu Asn Leu Ser Gln Gln Lys Lys Glu Lys 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Arg Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Cys Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Lys 
                405                 410                 415     


Arg Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Ala Leu Glu Gly Glu Ser 
    450                 455                 460                 


Val Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Glu Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Ala Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Leu Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Arg Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Lys Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Lys Gly Asp Lys Glu Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Glu Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Ser Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Lys Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Ala Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Val Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Glu Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Met Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Val Leu Val Pro Ala  Arg Ser Glu 
    1325                 1330                 1335             


Val Phe  Leu Lys Gln Phe Arg  Lys Ile Leu Glu Tyr  Arg Ile Gln 
    1340                 1345                 1350             


Asp Lys  Thr Gln 
    1355         


<210>  290
<211>  1169
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  290

Met Gly Ser Gly Lys Tyr Arg Ile Thr Lys Ile Ala Arg Asp Trp Asp 
1               5                   10                  15      


Glu Asn Lys Lys Arg Ile Ile Leu Lys Arg Ile Val Ser Asp Gly Glu 
            20                  25                  30          


Val Lys Tyr Val Asn Glu Asn Asn Asn Val Asp Ile Asp Ile Thr Glu 
        35                  40                  45              


Thr Tyr Tyr Arg Ile Leu Ser Asn Asn Lys Ala Lys Phe Leu Gly Ser 
    50                  55                  60                  


Asn Glu Gln Phe Ile Phe Lys Val Asn Lys Met Lys Arg Asn Ile Lys 
65                  70                  75                  80  


Asn Asp Cys Val Ile Ile Lys Asp Tyr Thr Glu Glu Glu Phe Glu Lys 
                85                  90                  95      


Leu Asp Lys Lys Ile Phe Phe Ser Arg Lys Ile Lys Val Asn Asn Lys 
            100                 105                 110         


Asp Arg Glu Lys Ile Cys Arg Asn Phe Tyr Glu Asp Glu Arg Glu Ile 
        115                 120                 125             


Met Lys Lys Arg Leu Glu Glu Ala Lys Lys Phe Asn Asn Ile Ile Phe 
    130                 135                 140                 


Asn Ile Cys Asn Lys Ile Phe Lys Leu Glu Tyr Leu Asp Tyr Thr Asp 
145                 150                 155                 160 


Glu Lys Val Tyr Lys Ile Phe Gln Asn Glu Ile Lys Val Lys Asp Val 
                165                 170                 175     


Lys Asn Leu Lys Glu Ala Phe Lys Gln Gln Glu Lys Gly Leu Glu Thr 
            180                 185                 190         


Asp Lys Leu Leu Ala Ile Ser Phe Asn Lys Lys Arg Asn Asn Ile Leu 
        195                 200                 205             


Leu Glu Phe Ile Gln Gln Ile Ala Lys Gln Glu Phe Glu Asn Gln Lys 
    210                 215                 220                 


Glu Leu Glu Asn Trp Phe Ser Tyr Gly Gly Glu Lys Tyr Cys Lys Glu 
225                 230                 235                 240 


Ile Phe Lys Ile Tyr Ser Asn Met Ser Gln Lys Glu Lys Tyr Phe Lys 
                245                 250                 255     


Leu Leu Gly His Arg Asn Gln Gly Ile Ala Ser Ile Tyr Asp Glu Lys 
            260                 265                 270         


Lys Glu Thr Leu Gln Arg Arg Leu Lys Leu Gly Asp Tyr Ser Lys Tyr 
        275                 280                 285             


Asp Leu Lys Arg Tyr Tyr Gln Lys Asp Tyr Lys Glu Glu Ala Ile Lys 
    290                 295                 300                 


Glu Leu Lys Asp Lys Asn Lys Glu Gly Leu Glu Arg Glu Ile Glu Glu 
305                 310                 315                 320 


Leu Ile Lys Lys Asn Tyr Lys Ile Asp Lys Leu Cys Asp Glu Ile Ser 
                325                 330                 335     


Asn Leu Glu Phe Ser Phe Val Glu Ser Lys Lys Glu Asn Lys Asp Lys 
            340                 345                 350         


Met Ser Glu Ile Ile Val Lys Ile Lys Glu His Tyr Lys Lys Asn Val 
        355                 360                 365             


Asn Val Glu Glu Glu Leu Glu Asn Lys Glu Lys Tyr Ile Leu Ser Ile 
    370                 375                 380                 


Ile His Asn Tyr Val Lys Gly Arg Tyr Arg Lys Cys Leu Glu Leu Gln 
385                 390                 395                 400 


Gln Lys Glu Asn Val Asp Phe Glu Asn Leu Glu Lys Arg Ile Lys Glu 
                405                 410                 415     


Ile Phe Asp Ser Asn Glu Val Thr Lys Lys Leu Lys Lys Ser Ile Ile 
            420                 425                 430         


Asn Lys Val Asn Ser Tyr Lys Ile Phe Glu Met Lys Phe Gln Asn Pro 
        435                 440                 445             


Asn Val Glu Ser Ser Asp Asp Leu Glu Ile Leu Lys Ala Glu Glu Thr 
    450                 455                 460                 


Phe Leu Asn Lys Leu Ser Thr Ala Val Ser Lys Val Gly Tyr Ile Leu 
465                 470                 475                 480 


Asn Ile Leu Leu Glu Ile His Phe Arg Asn Asp Ile Leu Gln Asp Tyr 
                485                 490                 495     


Asn Gln Val Glu Lys Leu Trp Lys Ser Asp Ser Phe Gln Lys Ile Cys 
            500                 505                 510         


Ala Ile Tyr Pro Glu Ile Asn Asn Asp Glu Lys Leu Leu Lys Gly Met 
        515                 520                 525             


Ile Tyr Phe Ile Gln Gly Leu Arg Gln Gln Val Leu His Pro Lys Ile 
    530                 535                 540                 


Leu Trp Glu Lys Gln Asn Ile Tyr Asn Ala Glu Asn Ile Lys Glu Lys 
545                 550                 555                 560 


Glu Lys Ile Val Ser Val Lys Leu Gln Asn Glu Gly Glu Ala Tyr Asn 
                565                 570                 575     


Lys Lys Gly Ile Gln Asn Tyr Phe Glu Asn Val Leu Lys Lys Ile Pro 
            580                 585                 590         


Asp Tyr Phe Ile Glu Lys Tyr Glu Ser Asn Asn Val Phe Asn Ile Tyr 
        595                 600                 605             


Arg Asn Ser Val Asp Lys Ile Met Glu Val Val Lys Asn Phe Asn Phe 
    610                 615                 620                 


Lys Glu Asn Asn Thr Ile Asp Tyr Leu Phe Pro Lys Phe His Lys Ile 
625                 630                 635                 640 


Tyr Lys Arg Met Cys Lys Ser Glu Asn Ile Asp Asp Arg Gln Asn Gly 
                645                 650                 655     


Ala Arg Lys Tyr Leu Leu Gln Thr Ile Tyr Tyr Tyr Tyr Phe Gln Tyr 
            660                 665                 670         


Glu Ile Glu Asn Asp Lys Asn Asn Met Ser Lys Tyr Leu Asn Leu Tyr 
        675                 680                 685             


Arg Asn Lys Ile Lys Val Lys Lys Ile Ser Tyr Ser Tyr Ile Ile Asp 
    690                 695                 700                 


Asn Lys Ala Val Asn Asn Lys Asn Ile Glu Ile Leu Tyr Arg Asn Ile 
705                 710                 715                 720 


Gln Arg Glu Gly Met Leu Asn Asn Arg Leu Leu Gln Met Asn Asn Glu 
                725                 730                 735     


Trp Ile Glu Phe Ile Val Val Gln Phe Ser Glu Phe Leu Thr Lys Lys 
            740                 745                 750         


Lys Leu Asn Trp Ile Leu Asp Asp Leu Ser Glu Tyr Lys Lys Lys Glu 
        755                 760                 765             


Lys Leu Asp Glu Asn Asp Lys Asn Glu Leu Leu Lys Ile Phe Lys Gln 
    770                 775                 780                 


Lys Met Asn Lys Asn Ile Thr Tyr Ser Asn Asp Ser Tyr Ala Phe Ile 
785                 790                 795                 800 


Ser Leu Ala Gln Phe Leu Asp Leu Lys Glu Ile Ser Asn Leu Ile His 
                805                 810                 815     


Asp Ile Lys Lys Phe Val Gln Phe Arg Glu Lys Asn Ile Leu Lys Tyr 
            820                 825                 830         


Asn Pro Glu Lys Asn Lys Ile Tyr Ile Glu Glu Leu Arg Lys Ile Leu 
        835                 840                 845             


Tyr Ile Leu Lys Val Met Leu Glu His Lys Glu Arg Val Ile Gln Lys 
    850                 855                 860                 


His Tyr Leu Gly Ser Tyr Asp Glu Asp Ile Ser Ile Met Tyr Gly Lys 
865                 870                 875                 880 


Asp Ile Glu Lys Lys Asp Ile Lys Asp Ile Glu Ile Lys Ile Lys Asn 
                885                 890                 895     


Lys Asn Gln Glu Val Ile Asn Gln Pro Leu Tyr Lys Ser Gly Asn Asp 
            900                 905                 910         


Glu Asn Ser Ser Trp Ile Ile Leu Tyr Gly Ile Glu Gln Ala Lys Arg 
        915                 920                 925             


Asn Gly Thr Phe Lys Phe Phe Glu Gly Phe Phe Asn Leu Asn Asp Asp 
    930                 935                 940                 


Ile Lys Leu Cys Lys Glu Asp Ile Glu Lys Tyr Glu Lys Leu Tyr Asn 
945                 950                 955                 960 


Glu Lys Glu Glu Asn Gln Lys Lys Val Asp Glu Tyr Ile Ser Lys Leu 
                965                 970                 975     


Asn Asn Asp Ile Glu Lys Ile Asn Asn Asp Ile Asn Ile Glu Lys Thr 
            980                 985                 990         


Asn Asp Asn Lys Gln Leu Phe Tyr  Tyr Tyr Lys Asn Met  Ile Tyr Gly 
        995                 1000                 1005             


Asp Gly  Leu Lys Lys Gly Tyr  Asp Phe Ile Asn Asp  Ile Tyr Ser 
    1010                 1015                 1020             


His Tyr  Leu Ser Trp Ala Tyr  Arg Ile Glu Arg Asp  Cys Lys Ile 
    1025                 1030                 1035             


Tyr Lys  Ile Lys Glu Tyr Glu  Asn Lys Lys Asn Phe  Asn Glu Tyr 
    1040                 1045                 1050             


Lys Phe  Lys Glu Tyr Lys Ser  Ile Lys Tyr Phe Arg  Asn Glu Ile 
    1055                 1060                 1065             


Ala His  Phe Asn Tyr Phe Gln  Lys Thr Asn Lys Ser  Leu Leu Glu 
    1070                 1075                 1080             


Leu Leu  Asn Asn Phe Tyr Asp  Ile Phe Asp Tyr Asn  Leu Lys Tyr 
    1085                 1090                 1095             


Gln Arg  Asp Val Gln Lys Val  Ile Asn Asn Ile Phe  Glu Lys Tyr 
    1100                 1105                 1110             


Gln Val  Ile Arg Glu Asp Gly  Gly Pro Val Ile Phe  Tyr Cys Lys 
    1115                 1120                 1125             


Ile Asp  Lys Lys Leu Lys Leu  Ser Glu Asn Ile Ile  Pro Lys Lys 
    1130                 1135                 1140             


His Leu  Lys Cys Ser Lys Ile  Lys Leu Ile His Glu  Lys Tyr Val 
    1145                 1150                 1155             


Glu Phe  Phe Arg Lys Leu Phe  Glu Tyr Lys Lys 
    1160                 1165                 


<210>  291
<211>  1231
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  291

Met Lys Val Thr Lys Ile Asp Gly Leu Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ile Glu Asp Ala Ser Gln Lys Asn Glu Thr 
            20                  25                  30          


Leu Glu Arg Leu Glu Lys Leu Lys Glu Ile Lys Leu Gly Asn Tyr Ile 
        35                  40                  45              


Lys Asn Pro Asp Lys Thr Lys Asp Lys Asp Asn Lys Lys Arg Arg Lys 
    50                  55                  60                  


Gly Leu Lys Glu Tyr Phe Ser Glu Ile Thr Leu Arg Lys Glu Asn Glu 
65                  70                  75                  80  


Lys Tyr Val Leu Leu Lys Gly Lys Lys Leu Lys Lys Ile Asn Asn Asp 
                85                  90                  95      


Ile Lys Asp Thr Asp Ile Lys Val Lys Tyr Lys Lys Glu Glu Val Phe 
            100                 105                 110         


Asp Val Leu Lys Lys Ile Leu Lys Leu Asn Leu Leu Ala Asn Asp Val 
        115                 120                 125             


Glu Glu Lys Ile Gln Phe Asp Ser Ile Lys Leu Lys Asn Val Phe Gly 
    130                 135                 140                 


Lys Asp Phe Val Lys Lys Glu Leu Gln Ile Lys Ser Ile Glu Glu Ser 
145                 150                 155                 160 


Leu Glu Lys Asn Lys Ala Asp Tyr Arg Lys Glu Phe Ile Glu Ile Glu 
                165                 170                 175     


Asn Asp Lys Tyr Gly Asn Val Lys Gly Glu Asn Lys Lys Asn Arg Ile 
            180                 185                 190         


Tyr Glu Tyr Tyr Lys Lys Ser Glu Thr His Glu Lys Phe Arg Lys Asn 
        195                 200                 205             


Ile Ile Glu Ala Phe Glu Lys Leu Tyr Lys Lys Asp Asp Ile Glu Lys 
    210                 215                 220                 


Leu Tyr Thr Gln Ile Ile Glu Ile Ser Lys Lys Met His Leu Lys Ser 
225                 230                 235                 240 


Lys Val Arg Glu Leu Tyr Lys Asn Val Ile Ile Lys Arg Ser Cys Asp 
                245                 250                 255     


Asp Phe Ser Lys Lys Asn Lys Glu Gly Ile Ser Val Leu Tyr Ser Gln 
            260                 265                 270         


Ile Met Asn Ser Val Lys Lys Asn Glu Lys Phe Val Lys Phe Val Lys 
        275                 280                 285             


Asn Ile Glu Leu Lys Asp Leu Thr Lys Ser Gln Ile Phe Tyr Lys Tyr 
    290                 295                 300                 


Phe Leu Glu Asn Glu Glu Leu Asn Asp Glu Asn Ile Lys Asn Ile Phe 
305                 310                 315                 320 


Cys Tyr Phe Val Glu Ile Glu Val Ser Asp Leu Leu Lys Gly Asn Val 
                325                 330                 335     


Tyr Lys Val Ser Lys Ile Tyr Glu Asn Lys Ile Lys Asn Ile Phe Glu 
            340                 345                 350         


Tyr Asn Lys Leu Lys Lys Leu Val Ile Asn Lys Leu Glu Asn Lys Leu 
        355                 360                 365             


Asn Asn Tyr Val Arg Asn Cys Gly Lys Tyr Asn Tyr His Met Glu Asn 
    370                 375                 380                 


Gly Asp Ile Ala Thr Ser Asp Ile Asn Met Arg Asn Arg Gln Thr Glu 
385                 390                 395                 400 


Ala Phe Leu Arg Ser Met Ile Gly Val Ser Ser Phe Gly Tyr Phe Ser 
                405                 410                 415     


Leu Arg Asn Ile Leu Gly Val Asn Asp Asp Asp Phe Tyr Glu Ile Glu 
            420                 425                 430         


Glu Asp Leu Thr Glu Glu Glu Arg Lys Asn Glu Ser Asn Val Leu Lys 
        435                 440                 445             


Lys Ala Lys Glu Asp Ile Thr Ser Lys Ser Ile Phe Glu Lys Val Val 
    450                 455                 460                 


Asp Lys Ser Phe Glu Lys Lys Gly Ile His Ser Ile Arg Glu Asn Val 
465                 470                 475                 480 


Lys Met Phe Tyr Gly Asp Ser Phe Asp Lys Ala Asn Glu Asp Glu Leu 
                485                 490                 495     


Lys Gln Phe Phe Val Asn Met Leu Asn Ala Ile Thr Ser Ile Arg His 
            500                 505                 510         


Arg Val Val His Tyr Asn Met Asn Thr Asn Ser Glu Asn Ile Phe Asn 
        515                 520                 525             


Phe Ser Asp Ile Glu Val Ser Arg Leu Leu Lys Ser Ile Phe Glu Lys 
    530                 535                 540                 


Glu Thr Asp Lys Arg Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn 
545                 550                 555                 560 


Ser Ala Gly Val Phe Asp Tyr Trp Glu Asn Trp Lys Ile Lys Lys Tyr 
                565                 570                 575     


Leu Glu Asn Met Lys Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val 
            580                 585                 590         


Pro Ser Phe Thr Lys Leu Tyr Asn Arg Ile Asp Asn Leu Lys Gly Ser 
        595                 600                 605             


Asn Ala Leu Asn Leu Gly Tyr Ile Asn Ile Pro Lys Arg Lys Glu Ala 
    610                 615                 620                 


Arg Asp Ser Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Lys Phe 
625                 630                 635                 640 


Val Glu Glu Phe Ile Lys Asn Asn Asp Asn Phe Glu Lys Ile Phe Arg 
                645                 650                 655     


Glu Ile Ile Glu Ile Asn Lys Asn Ala Gly Thr Asn Lys Gln Thr Asn 
            660                 665                 670         


Phe Tyr Lys Leu Glu Lys Phe Glu Lys Leu Lys Ala Asn Thr Pro Thr 
        675                 680                 685             


Glu Tyr Leu Glu Lys Leu Gln Ser Leu His Lys Ile Asn Tyr Asn Arg 
    690                 695                 700                 


Glu Lys Ile Glu Glu Asp Lys Asp Ile Tyr Val Asp Phe Val Gln Lys 
705                 710                 715                 720 


Ile Phe Leu Lys Gly Phe Ile Ser Tyr Leu Gln Lys Ser Asn Ser Leu 
                725                 730                 735     


Lys Pro Leu Asn Leu Leu Asn Leu Lys Lys Asp Glu Val Ile Asn Ser 
            740                 745                 750         


Glu Lys Ser Phe Tyr Asp Glu Lys Leu Lys Gln Trp Glu Asn Asn Gly 
        755                 760                 765             


Ser Asn Leu Ser Glu Met Pro Lys Glu Ile Tyr Lys Tyr Ile Lys Glu 
    770                 775                 780                 


Ile Lys Ile Asn Lys Thr Asn Tyr Ser Asp Arg Met Ser Ile Phe Tyr 
785                 790                 795                 800 


Leu Leu Leu Lys Leu Ile Asp His Lys Glu Leu Thr Asn Leu Arg Gly 
                805                 810                 815     


Asn Leu Glu Lys Tyr Glu Ser Met Asn Lys Asn Lys Ile Tyr Ser Glu 
            820                 825                 830         


Glu Leu Asn Ile Val Asn Leu Val Ser Leu Asp Asn Asn Lys Val Arg 
        835                 840                 845             


Thr Asn Phe Ser Val Glu Ala Glu Asp Ile Gly Lys Phe Leu Lys Thr 
    850                 855                 860                 


Glu Thr Ser Ile Lys Asn Ile Asn Gln Leu Asn Asn Phe Ser Gly Ile 
865                 870                 875                 880 


Phe Ala Asp Gly Glu Asn Val Ile Lys His Arg Ser Phe Tyr Asn Ile 
                885                 890                 895     


Lys Lys Tyr Gly Ile Leu Asp Leu Leu Glu Lys Ile Val Ala Lys Ala 
            900                 905                 910         


Asp Leu Lys Ile Ala Lys Glu Glu Ile Lys Lys Tyr Glu Asn Leu Gln 
        915                 920                 925             


Lys Glu Leu Glu Lys Asn Asp Phe Tyr Lys Ile Gln Glu Lys Ile His 
    930                 935                 940                 


Arg Lys Tyr Asn Gln Lys Pro Asn Leu Ile Ser Arg Thr Glu Asn Lys 
945                 950                 955                 960 


Lys Asp Phe Asn Asp Tyr Lys Lys Ala Ile Glu Asn Ile Gln Asn Tyr 
                965                 970                 975     


Thr Gln Leu Lys Asn Lys Ile Glu Phe Asn Asp Leu Asn Leu Leu Gln 
            980                 985                 990         


Gly Leu Leu Phe Arg Ile Leu His  Arg Leu Thr Gly Tyr  Thr Ser Leu 
        995                 1000                 1005             


Trp Glu  Arg Asp Leu Gln Phe  Lys Leu Lys Gly Glu  Phe Pro Glu 
    1010                 1015                 1020             


Asp Lys  Tyr Ile Asp Glu Ile  Phe Asn Ser Asp Arg  Asn Asn Asn 
    1025                 1030                 1035             


Gln Lys  Tyr Lys Ser Gly Gly  Ile Ala Tyr Lys Tyr  Val Asp Phe 
    1040                 1045                 1050             


Leu Ile  Glu Lys Glu Glu Gly  Lys Arg Ala Gly Lys  Asn Lys Val 
    1055                 1060                 1065             


Lys Lys  Arg Ser Glu Arg Glu  Arg Ser Phe Ile Ile  Arg Asn Tyr 
    1070                 1075                 1080             


Ile Ala  His Phe Asn Tyr Ile  Pro Asp Ala Glu Lys  Ser Ile Leu 
    1085                 1090                 1095             


Glu Ile  Leu Glu Glu Leu Arg  Glu Leu Leu Lys Tyr  Asp Arg Lys 
    1100                 1105                 1110             


Leu Lys  Asn Ala Val Met Lys  Ser Ile Lys Asp Ile  Phe Lys Glu 
    1115                 1120                 1125             


Tyr Gly  Phe Ile Ile Glu Phe  Gly Ile Ser His Glu  Ser Asn Ser 
    1130                 1135                 1140             


Lys Lys  Ile Lys Val Leu Asn  Val Glu Ser Gly Lys  Ile Lys His 
    1145                 1150                 1155             


Leu Lys  Asn Asn Gly Leu Val  Thr Thr Lys Asp Ile  Phe Lys Glu 
    1160                 1165                 1170             


Tyr Gly  Phe Ile Ile Glu Phe  Gly Ile Ser His Glu  Ser Asn Ser 
    1175                 1180                 1185             


Lys Lys  Ile Lys Val Leu Asn  Val Glu Ser Glu Lys  Ile Lys His 
    1190                 1195                 1200             


Leu Lys  Asn Asn Gly Leu Val  Thr Thr Arg Asn Ser  Lys Asp Leu 
    1205                 1210                 1215             


Cys Lys  Leu Val Lys Val Met  Leu Glu Tyr Lys Lys  Ser 
    1220                 1225                 1230     


<210>  292
<211>  1265
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  292

Met Lys Ile Thr Lys Arg Lys Trp Glu Arg Glu Pro Pro Leu Phe Phe 
1               5                   10                  15      


Tyr Arg Asp Ala Glu Ser Gly Lys Leu Val Met Gln Gly Asp Lys Leu 
            20                  25                  30          


Arg Asp Phe Thr Asp Thr Leu Phe Ser Glu Lys Ser Val Lys Ala Val 
        35                  40                  45              


Phe Glu Arg Ser Leu Lys Ser Arg Leu Leu Lys Ser Cys Asp Lys Asp 
    50                  55                  60                  


Gly Lys Arg Leu Glu Lys Asn Glu Ile Thr Glu Leu Val Glu Ser Leu 
65                  70                  75                  80  


Cys Lys Lys Ser Leu Cys Lys Asp Thr Arg Leu Lys Lys Ser Ile Glu 
                85                  90                  95      


Glu Val Arg Arg Leu Pro Pro Lys Thr Ala Ile Glu Gln Cys Asn Lys 
            100                 105                 110         


Ser Leu Ser Gly Tyr Gly Lys Ser Phe Thr Ala Pro Gly Ser Thr Lys 
        115                 120                 125             


Thr Leu His Ala Val Leu Leu Asp Leu Ile Asn Gly Asn Asp Val Gln 
    130                 135                 140                 


Lys Ala Met Ala Glu Ala Glu Leu Glu Lys Ile His Gln Ala Leu Ile 
145                 150                 155                 160 


Lys Gly Ile Asp His Arg Ile Asn Arg Val Arg Asn Ser Ile Lys Gly 
                165                 170                 175     


Asn Lys Ile Pro Leu Ile Ile Lys Asp Asp Gly Ser Ile Ala Ala Asn 
            180                 185                 190         


Asn Asp Arg Ala Ala Trp Leu Leu Glu Leu Leu Gln Pro Ala Gln Ser 
        195                 200                 205             


Ile His Ser Ser Gln Pro Gly Tyr Lys Ala Asp Phe Tyr Pro Val Leu 
    210                 215                 220                 


Thr Glu Met Glu Arg Ile Phe Ser Phe Glu Lys Leu Ser Arg Glu Ile 
225                 230                 235                 240 


Arg Thr Gln Thr Asp Arg Tyr Asn Gly Lys Ala Gln Leu Ile Ala Lys 
                245                 250                 255     


Ala Ala Asp Glu Thr Leu Arg Asn Tyr Leu Arg Asp Leu Trp Glu Lys 
            260                 265                 270         


Tyr Pro Asp Arg His Arg Asp Met Lys Tyr Tyr Phe Gln Ala Val His 
        275                 280                 285             


Glu Tyr Phe Arg Glu Asn Phe Pro Ile Arg Arg Lys Arg Glu Gly Ala 
    290                 295                 300                 


Arg Asn Arg Gln Glu Leu Leu Ala Asn Lys Asp Ala Leu Ser Arg Leu 
305                 310                 315                 320 


Leu Glu Pro Lys His Ile Glu Asn Ala Val Arg Arg Lys Leu Ile Asn 
                325                 330                 335     


Gln Cys Thr Gln Ile Asn Ile Leu Tyr Gly Lys Leu Tyr Glu Tyr Cys 
            340                 345                 350         


Cys Lys Ser Asp Asn Met Leu Thr Val Asp Ser Glu Thr Leu Gln Arg 
        355                 360                 365             


Ile Gln Val Leu Glu Ala Val Lys Lys Gln Ala Met Thr Ala Val Leu 
    370                 375                 380                 


Trp Ser Ile Ser Arg Leu Arg Tyr Phe Tyr Glu Asn Asn Tyr Lys Asp 
385                 390                 395                 400 


Ile Ser Lys Ile Asp Ile Leu Ser Asp Lys Gln Glu Val Lys Asp Phe 
                405                 410                 415     


Arg Lys Lys Phe Leu Thr Cys Asn Thr Tyr Ser Asp Glu Phe Val Gln 
            420                 425                 430         


Ala Cys Lys Glu Lys Leu Gln Asp Phe Phe Pro Leu Glu Val Lys Asn 
        435                 440                 445             


Glu Lys Cys Asn Cys Asp Gly Gly Gln Lys Tyr Lys Asp Ala Glu Glu 
    450                 455                 460                 


Thr Cys Lys Asp Ile Glu Glu Ile Phe Ser Asp Asp Arg Lys Leu Cys 
465                 470                 475                 480 


Asn Gly Leu Leu Met Glu Cys Val Phe Tyr Ile Arg Ser Leu Arg Leu 
                485                 490                 495     


Lys Ile Phe His Tyr Lys Asn Met Ser Phe Thr Gln Ala Leu Lys Lys 
            500                 505                 510         


Ile Val Asp Glu Val Glu Glu Glu Glu Asn Lys Asn Glu Lys Glu Lys 
        515                 520                 525             


Lys Asn Ile Leu Leu His Leu Tyr Lys Arg Asp Arg Asn Asn Leu Asn 
    530                 535                 540                 


Lys Ala Phe Ala Tyr Lys Ile Ser Ser Met Asn Ile Pro Leu Tyr Tyr 
545                 550                 555                 560 


Arg Asp Asp Leu Leu Ser Arg Ile Phe Thr Lys Asp Gly Ala Glu Phe 
                565                 570                 575     


Ser Leu Tyr Ser Ala Asn Asn Gln Met Thr Pro Ser Phe Arg Arg Val 
            580                 585                 590         


Tyr Glu Arg Gly Lys Asn Leu Arg Leu Glu Trp Glu Arg Lys His Met 
        595                 600                 605             


Asn Glu Gln Ala Ile Met Glu Cys Asp Glu Lys Asn Ser Leu Glu Asn 
    610                 615                 620                 


Glu Cys Tyr Leu Lys Trp Phe Lys Gln Leu Asn Asn Thr Tyr Glu Thr 
625                 630                 635                 640 


Asp Asp Thr Asp Ala Lys Ala Gly Val Asn Thr Asp Asp Glu Ala Cys 
                645                 650                 655     


Ala Asn Val Tyr Ile Asn Glu Asp Val Gly Ala Asp Thr Lys Ala Asp 
            660                 665                 670         


Thr Glu Asp Thr Asn Ala Asp Ala Gln Arg Ala Val Arg Asn Leu Leu 
        675                 680                 685             


Gln Leu Ile Tyr Lys His His Phe Leu Pro Glu Val Gln Lys Asn Asp 
    690                 695                 700                 


Ala Leu Val Thr Ser Lys Ile Ser Lys Val Leu Glu Arg Asn Lys Lys 
705                 710                 715                 720 


Leu Ala Glu Glu Arg Ser Glu Lys Gln Ala Glu Lys Arg Ser Arg Ala 
                725                 730                 735     


Leu Lys Ile Glu Trp Glu Arg Pro Arg Glu Val Arg Asn Phe Ala Tyr 
            740                 745                 750         


Lys Glu Val Val Asn Leu Tyr Arg Glu Gly Met Pro Leu Ser Asp Phe 
        755                 760                 765             


Leu Glu Glu Leu Gln Arg Lys Ile Ser Glu Thr Glu Lys Glu Asn Arg 
    770                 775                 780                 


Glu Leu Ala Gln Asn Lys Ala Asp Tyr Ala Gln Arg Phe Ile Arg Glu 
785                 790                 795                 800 


Val Phe Ala Glu Ala Phe Asn Ser Phe Met Gln Glu Arg Tyr Gly Asp 
                805                 810                 815     


Val Tyr Asp Glu Ile Met Asn Pro Gln Lys Asn Thr Glu Gln Ala Lys 
            820                 825                 830         


Lys Trp Ile Glu Ile Asp Asp Ala Val Asn Leu Cys Thr Thr Phe Asp 
        835                 840                 845             


Lys Asn Glu Ile Glu Lys Tyr Leu Leu Val Leu Tyr Pro Val Met Arg 
    850                 855                 860                 


Leu Leu Asp Glu Lys Glu Leu Ser Glu Leu Gln Gln Gln Met Leu Arg 
865                 870                 875                 880 


Leu Arg Ala Ser Met Ser Glu Trp Gln Gly Glu Thr Asp Phe Ser Glu 
                885                 890                 895     


Asp Ile Lys Ile Ala Glu Lys Ile Glu Glu Leu Ala Glu Leu Val Lys 
            900                 905                 910         


Leu Thr Glu Pro Asp Thr Lys Tyr Ala Glu Glu Thr Trp Lys Ser Arg 
        915                 920                 925             


Ala Gln Lys Glu Phe Glu Gln Phe Val Glu Gly Ser Met Ser Asp Tyr 
    930                 935                 940                 


Gly Thr Phe Tyr Leu His Ser Asn Lys Ser Asn Pro Val Ile Arg Arg 
945                 950                 955                 960 


Asn Met Thr Arg Leu Leu Arg Ser Gly Ala Ile Glu Val Tyr Lys Arg 
                965                 970                 975     


Val Leu Ser Ser Arg Lys Gln Ala Thr Lys Ser Asp Tyr Asp Ile Tyr 
            980                 985                 990         


Cys Gly Arg Gln Trp Val Met Glu  Asp Ser Asp Gly Arg  Tyr Ile Thr 
        995                 1000                 1005             


Phe Val  Glu Tyr Ala Gln Arg  Val Leu Gln Gln Leu  His Ser Lys 
    1010                 1015                 1020             


Tyr Ala  Val Ser Pro Ser Arg  Phe Ser Glu Ala Asp  His Lys Ser 
    1025                 1030                 1035             


Tyr Asp  Asn Ile Leu Gln Trp  Leu Glu Glu Tyr Asn  Gln Ala Lys 
    1040                 1045                 1050             


Arg Asn  Leu Asp Phe Gly Thr  Leu Tyr Glu Thr Cys  Gly Ile Asn 
    1055                 1060                 1065             


Met Glu  Ile Leu Ser Arg Trp  Val Gly Phe Val Gln  Asp Trp Glu 
    1070                 1075                 1080             


Arg Asp  Met Tyr Phe Leu Leu  Leu Ala Trp Val Lys  Gln Gly Lys 
    1085                 1090                 1095             


Leu Tyr  Gln Ile Lys Glu Glu  Asp Val Glu Gly Ile  Phe Ala Lys 
    1100                 1105                 1110             


Gly Asn  Val Ile Arg Lys Leu  Phe Asp Thr Leu Lys  Asp Arg Asn 
    1115                 1120                 1125             


Met Asp  Ala Phe Lys Ser Val  Tyr Cys Leu Cys Asp  Asp Thr Glu 
    1130                 1135                 1140             


Met Asn  Phe Val Lys Val Arg  Asn Asp Ile Ala His  Leu Asp Leu 
    1145                 1150                 1155             


Leu Arg  Ser Ser Asn Trp Thr  Val Gly Glu Asn Gln  Ser Gly Ser 
    1160                 1165                 1170             


Val Met  Glu Trp Tyr Ile Asn  Arg Leu Arg Ser Leu  Leu Ser Tyr 
    1175                 1180                 1185             


Asp Gln  Lys Arg Met Asn Ala  Val Thr Lys Thr Met  Gln Glu Ile 
    1190                 1195                 1200             


Phe Arg  Lys His Asn Ile Glu  Val Lys Phe Thr Met  Glu Arg Gly 
    1205                 1210                 1215             


Gly Lys  Leu Lys Phe Lys Glu  Val Lys Pro Glu Cys  Ile Glu His 
    1220                 1225                 1230             


Leu Lys  Lys Ser Arg Phe Arg  Glu Glu Met Lys Ile  Glu Ile Ser 
    1235                 1240                 1245             


Ser Arg  Gly Glu Arg Phe Leu  Ser Asn Leu Glu Gly  Leu Met Lys 
    1250                 1255                 1260             


Tyr Ser  
    1265 


<210>  293
<211>  1288
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  293

Met Lys Leu Thr Arg Lys Arg Ile Gly Gln Gly Arg Asn Asn Gln Lys 
1               5                   10                  15      


Val Thr Ala Ala Phe Tyr Arg Asp Met Ala Ser Gly Leu Leu Tyr Val 
            20                  25                  30          


Asp Ser Glu Asp Asn Asp Arg Thr Glu Glu Ile Ile Asn Ser Met Asp 
        35                  40                  45              


Phe Glu Arg Ser Trp Arg Gly Arg Ile Leu Lys Asn Ala Glu Ser Gly 
    50                  55                  60                  


Lys Asn Pro Phe Asn Met Phe Val Lys Gly Leu Ile Val Ala Asn Glu 
65                  70                  75                  80  


Ala Ile Val Cys Lys Pro Val Phe Asn Asn Asp Ile Asp Ile Thr Lys 
                85                  90                  95      


Phe Met Asn Lys Tyr Leu Thr Asp Phe Gly Arg Asn Leu Lys Ala Pro 
            100                 105                 110         


Gly Ser Asp Ile Thr Leu Lys Asp Ile Ile Arg Lys Met Gln Gly Gly 
        115                 120                 125             


Ala Pro Glu Glu Glu Ile Arg Arg Glu Leu Glu Lys Ile Lys Glu Met 
    130                 135                 140                 


Ile Gly Asn Asp Ile Arg Lys Arg Lys Glu Gln Leu Ser Glu Ser Ile 
145                 150                 155                 160 


Ala Asn Asn Arg Ile Pro Phe Ser Thr Val Asn Asn Lys Leu Met Pro 
                165                 170                 175     


Ser Ala Arg Lys Met Lys Trp Leu Tyr Lys Leu Leu Asp Gly Glu Asn 
            180                 185                 190         


Gly Ala Phe Asn Gly Gln Met Leu Asp Glu Tyr Trp Asn Lys Tyr Asn 
        195                 200                 205             


Tyr Arg Lys Leu Glu Ala Val Ile Ile Glu Glu Ile Glu Ser Leu Gln 
    210                 215                 220                 


Asp Lys Asn Ala Arg Ser Ile Ser Lys Ala Val Ser Arg Ala Val Arg 
225                 230                 235                 240 


Asp Tyr His Arg Asn Phe Arg Thr Asp Tyr Asn Asp Thr Ala Leu Arg 
                245                 250                 255     


Glu Pro Asp Gly Thr Gly His Asn Asn Asn Asp Thr Ala Gly Asn Pro 
            260                 265                 270         


Asp Lys Glu Gly Phe Leu Leu Phe Leu Lys Ala Val Glu Gln His Phe 
        275                 280                 285             


Lys Lys Tyr Tyr Pro Val Lys Ser Lys His Ser Ser Asp Ala Arg Asp 
    290                 295                 300                 


Lys Ser Leu Cys Asp Glu Lys Asn Tyr Lys Phe Tyr Cys Ser His Asp 
305                 310                 315                 320 


Phe Val Lys Asn Glu Val Ser Arg Ser Ile Ile Asn Gln Leu Val Ser 
                325                 330                 335     


Gly Leu Ile Gln Gln Gly Lys Leu Leu His Tyr Phe Tyr Asp Gly Gly 
            340                 345                 350         


Thr Trp Gln Gln Asp Phe Leu Asn Ser Tyr Gly Leu Ser Tyr Ile Gln 
        355                 360                 365             


Val Glu Glu Ala Phe Lys Lys Ser Leu Met Ser Ser Leu Ser Trp Gly 
    370                 375                 380                 


Ile Asn Arg Leu Thr Thr Phe Phe Ile Asp Gly Ile Thr Glu Gly Leu 
385                 390                 395                 400 


Gly Gly Arg Ser Asn Asp Ala Gly Leu Ile Asp Asp Ile Leu Leu Glu 
                405                 410                 415     


Asn Gln Lys Ile Arg Ala Phe Arg Glu Asn Phe Tyr Asn Ser Leu Arg 
            420                 425                 430         


Asp Asn Arg Ser Lys Glu Gly Lys Glu Leu Gln Lys Arg Phe Ile Glu 
        435                 440                 445             


Lys Leu Ala Ala Cys Tyr Pro Val Ile Val Lys Asp Asp Gly Glu Lys 
    450                 455                 460                 


Ser Gly Asp Asp Ile Glu Lys Leu Ile Gly Leu Val Glu Glu Ala Arg 
465                 470                 475                 480 


Asn Ser Val Ala Tyr Leu Arg His Ser Ser Phe His Phe Lys Lys Val 
                485                 490                 495     


Ser Leu Pro Glu Met Leu Lys Asp Leu Asn Asp Asp Lys Ala Tyr His 
            500                 505                 510         


Asn Thr Gly Gln Lys Gly His Lys Ala Ala Lys Ala Asp Tyr Ser Ile 
        515                 520                 525             


Ala Glu Glu Leu Phe Arg Arg Asp Ile Asp Arg Leu Tyr Asp Ala Phe 
    530                 535                 540                 


Arg Glu Gln Ile Arg Ser Leu Gly Ile Val Glu Tyr Tyr Pro Thr Gly 
545                 550                 555                 560 


Leu Ile Ser Asp Cys Phe Lys Thr Cys Gly Met Glu Phe Thr Leu Tyr 
                565                 570                 575     


Ser Pro Gln Asn Ser Leu Ile Pro Ser Phe Lys Lys Val Tyr Lys Arg 
            580                 585                 590         


Gly Ser Asn Leu Tyr Lys Ala Tyr Lys Glu Lys Val Gln Asn Val Ser 
        595                 600                 605             


Asp Gly Gln Glu Glu Lys Asn Ala Arg Thr Asp Gln Lys Asp Gln Glu 
    610                 615                 620                 


Glu Phe Lys Glu Leu Gly Trp Tyr Ile Glu Val Ser Asn Asn Glu Pro 
625                 630                 635                 640 


Gly Trp Leu Ala Tyr Lys Asn Leu Leu Gln Leu Ile Tyr Tyr His Ala 
                645                 650                 655     


Phe Leu Pro Glu Val Tyr Gln Asn Glu Ala Leu Ile Thr Gly Phe Ile 
            660                 665                 670         


Asn Arg Thr Lys Asp Trp Asn Arg Lys Glu Ala Glu Lys Ala Ala Ala 
        675                 680                 685             


Lys Lys Asn Asp Phe Asn Arg Asn Lys Asp Arg Ala Phe Met Ala Tyr 
    690                 695                 700                 


Arg Tyr Glu Ala Val Pro Asp Tyr Gln Gly Glu Pro Leu Glu Asp Tyr 
705                 710                 715                 720 


Phe Lys Val Leu Gln Arg Glu Gln Met Ala Arg Ala Lys Glu Val Ser 
                725                 730                 735     


Glu Gly Ser Ala Glu Asn Asn Thr Tyr Ile Gln Phe Ile Gln Asp Val 
            740                 745                 750         


Ile Val Trp Ala Phe Gly Ala Tyr Leu Glu Arg Leu Val Asn Tyr Arg 
        755                 760                 765             


Glu Ala Leu Gln Lys Pro Ser Leu Gln Glu Lys Lys Val Asn Glu Ala 
    770                 775                 780                 


Leu Asn Glu Leu Leu Pro Glu Lys Met Glu Glu Ser Gln Phe Phe Met 
785                 790                 795                 800 


Val Cys Arg Phe Asn Lys Asp Lys Ile Asn Asn Ser Gly Glu His Ile 
                805                 810                 815     


Thr Ser Ala Gly Lys Thr Gln Ile Gly Gln Arg Lys Asp Leu Leu Cys 
            820                 825                 830         


Phe Tyr Leu Phe Leu Arg Leu Leu Asp Ala Arg Glu Val Ser Gly Leu 
        835                 840                 845             


Gln His Gln Phe Ile Arg Tyr Arg Cys Ser Leu Lys Glu Arg Arg Leu 
    850                 855                 860                 


Pro Asp Asn Arg Arg Asp Ile Glu Glu Glu Ile Glu Leu Phe Glu Glu 
865                 870                 875                 880 


Leu Glu Glu Leu Met Glu Leu Val Arg Tyr Thr Val Pro Ser Val Thr 
                885                 890                 895     


Glu Leu Leu Gly Arg Ala Gly Ser Gly Phe Asp Thr Val Ile Gln Asp 
            900                 905                 910         


His Phe Arg Glu Phe Phe Asp Asn Arg Ala Leu Glu Asn Asp Asp Ile 
        915                 920                 925             


Arg Lys Leu Tyr Tyr Gln Ser Asp Glu Lys Thr Pro Val Pro Arg Lys 
    930                 935                 940                 


His Met Ala Leu Leu Met Arg Ser Ala Pro Leu Arg Leu Tyr Lys Asp 
945                 950                 955                 960 


Met Phe Arg Asn Tyr Tyr Leu Ile Thr Glu Lys Glu Cys Leu Glu Phe 
                965                 970                 975     


Ile Gln Leu Ser Arg Asn Ile Asp Ser Tyr Gln Gly Arg Leu Asn Glu 
            980                 985                 990         


Leu His Lys Gln Leu Glu Gln Val  Lys Val Lys Ser Val  Lys Ile Asn 
        995                 1000                 1005             


Asn Gln  Lys Gly Lys Thr Tyr  Ser Phe Leu Glu Asp  Lys Asp Ala 
    1010                 1015                 1020             


Gln Lys  Val Ala Glu Tyr Glu  Asp Asn Leu Asn Thr  Val Ile Arg 
    1025                 1030                 1035             


Tyr Lys  His Leu Gln Arg Lys  Leu Thr Phe Glu Ala  Leu Tyr Thr 
    1040                 1045                 1050             


Ile Phe  Arg Val His Val Asp  Val Ala Ala Arg Met  Ile Gly Tyr 
    1055                 1060                 1065             


Ala Gln  Asp Trp Glu Arg Asp  Met Phe Phe Leu Leu  Lys Ser Leu 
    1070                 1075                 1080             


Glu Tyr  Asn Gly Lys Ile Arg  Tyr Gly Met Val Glu  Ser Ile Phe 
    1085                 1090                 1095             


Ser Glu  Gly Ser Ile Val Arg  Lys Leu Gln Ile Ile  Leu Ser Pro 
    1100                 1105                 1110             


Asp Glu  Lys Glu Ile Leu Cys  Met Leu Cys Trp His  Lys Lys Leu 
    1115                 1120                 1125             


Ser Asp  Lys Glu Phe Tyr Tyr  Arg Ile Arg Ile Arg  Asn Pro Ile 
    1130                 1135                 1140             


Ala His  Leu Asn His Phe Thr  Gln Thr Ser Ala Asn  Pro Asn Gly 
    1145                 1150                 1155             


Ser Leu  Glu Ala Met Leu Asn  Asp Leu Arg Ser Leu  Leu His Tyr 
    1160                 1165                 1170             


Asp Arg  Lys Arg Gln Asn Thr  Val Thr Lys Thr Ile  Asn Asp Ile 
    1175                 1180                 1185             


Leu Leu  Lys Asp Tyr Asn Ile  Arg Ile Lys Trp Lys  Arg Thr Leu 
    1190                 1195                 1200             


Ser Asn  Lys Asn Asn Gly Lys  Met Glu Phe Lys Ile  Val Glu Pro 
    1205                 1210                 1215             


Leu Glu  Asn Glu Pro Ile Val  His Leu Lys His Ile  Arg Lys Gly 
    1220                 1225                 1230             


Asp Lys  Cys Arg Val His Asn  Lys Ala His Met Leu  Arg Lys Gln 
    1235                 1240                 1245             


Glu Ala  Trp Leu His Lys Gly  Ile Ile Glu Asn Ala  His Asp Gly 
    1250                 1255                 1260             


Asp Ile  Leu Arg Cys Ile Tyr  Arg Leu Leu Ala Phe  Arg Tyr Pro 
    1265                 1270                 1275             


Pro Val  Arg Thr Tyr Gly Ile  His Lys Lys 
    1280                 1285             


<210>  294
<211>  1259
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  294

Met Lys Leu Thr Arg Arg Lys Ile Glu Glu Gly Lys Lys Tyr Arg Ala 
1               5                   10                  15      


Thr Phe Tyr Arg Asp Thr Thr Arg Gly Leu Leu Tyr Phe Asp Ser Glu 
            20                  25                  30          


Lys Val Asp Ser Thr Glu Lys Val Val Asn Ser Met Asn Phe Val Arg 
        35                  40                  45              


Ser Met Arg Gly Arg Ile Leu Lys His Ala Glu Lys Gly Asp Asn Pro 
    50                  55                  60                  


Phe Tyr His Leu Val Asp Gly Leu Val Asn Pro Val Ala Pro Ile Ala 
65                  70                  75                  80  


Ser Glu Pro Val Asp Met Lys Gly Lys Asp Ile Ser Glu Val Ile Asn 
                85                  90                  95      


Lys Asn Leu Thr Glu Phe Gly Lys Lys Leu Lys Ala Pro Asp Ser Ile 
            100                 105                 110         


Tyr Thr Leu Glu Glu Leu Ile Leu Lys Ile Gln Ser Lys Asp Asn Pro 
        115                 120                 125             


Asp Glu Ile Lys Ser Glu Leu Gln Lys Ile Arg Lys Cys Leu Glu Thr 
    130                 135                 140                 


Asp Ile Lys Asn Arg Lys Glu Gln Leu Ile Thr Ser Ile Ala Asn Asn 
145                 150                 155                 160 


Asn Ile Pro Phe Ser Val Ile Asn Gly Lys Leu Lys Pro Ala Ser Arg 
                165                 170                 175     


Lys Met Gln Trp Leu Phe Lys Leu Leu Thr Glu Arg Thr Arg Met Lys 
            180                 185                 190         


Pro Glu Asp Lys Val Pro Ser Ile Glu Glu Lys Leu Asp Lys Tyr Trp 
        195                 200                 205             


Glu Arg Tyr Asn Tyr Lys Lys Leu Glu Lys Leu Ile Thr Asp Asn Val 
    210                 215                 220                 


Glu Lys Leu Glu Asn Glu Pro Ala Ala Arg Val Ile Ala Asn Thr Val 
225                 230                 235                 240 


Phe Lys Cys Val Arg Asp Tyr His His Asn Leu Arg Leu Ser Leu Ser 
                245                 250                 255     


Glu Ser Ser Glu Glu Asp Gln Asp Phe Lys Leu Phe Ile Lys Glu Val 
            260                 265                 270         


Glu Gln His Phe Lys Lys Tyr Tyr Pro Val Lys Ser Lys Asp Ser Asn 
        275                 280                 285             


Ser Glu Tyr Asp Asn Phe Leu Cys Lys Asp Asn Asn Tyr Arg Phe Tyr 
    290                 295                 300                 


Cys Ser Cys His Ile Val Lys Arg Glu Val Asn Arg Ser Ile Ile Asn 
305                 310                 315                 320 


Gln Leu Val Ala Gly Leu Ile Gln Gln Gly Lys Leu Leu His Tyr Phe 
                325                 330                 335     


Tyr Asp Tyr Glu Lys Gly Leu Trp Gln Lys Asp Phe Leu Asn Ser His 
            340                 345                 350         


Gly Leu Ser Tyr Ile Gln Val Glu Glu Ala Phe Lys Lys Ser Leu Met 
        355                 360                 365             


Ser Ala Leu Thr Trp Gly Ile Asn Arg Leu Ile Phe Phe Tyr Tyr Asp 
    370                 375                 380                 


Gly Lys Glu Lys Phe Pro Asp Lys Ser Asp Ile Leu Leu Asn Pro Lys 
385                 390                 395                 400 


Lys Asp Lys Lys Tyr Asn Ile Asn Asp Tyr Arg Lys Asn Tyr Tyr Lys 
                405                 410                 415     


Arg Ile Lys Asp Asp Ser Lys His Phe Lys Glu Lys Leu Ala Ala Cys 
            420                 425                 430         


Phe Ser Val Lys Val Lys Glu Glu Asn Asn Arg Asn Asn Asp Ser Val 
        435                 440                 445             


Asp Lys Leu Ile Asp Leu Val Glu Val Thr Arg Lys Ser Val Ala Asn 
    450                 455                 460                 


Ile Arg His Asn Ile Phe His Tyr Lys Glu Glu Ser Leu Leu Lys Ile 
465                 470                 475                 480 


Leu Glu Ser Gly Gly Gln Lys Lys Glu Asn Glu Lys Ser Asn Gln Asn 
                485                 490                 495     


Gly Lys Ser Ile Lys Tyr Asn Val Ala Lys Glu Phe Phe Ile Arg Asp 
            500                 505                 510         


Ile Lys Asn Leu Thr Asp Ala Phe Arg Glu Gln Ile Arg Ser Leu Gly 
        515                 520                 525             


Ile Leu Glu Tyr Tyr Pro Leu Ser Leu Leu Ile Asn Cys Phe Asp Ala 
    530                 535                 540                 


Cys Gly Leu Glu Phe Lys Leu Tyr Thr Ser Gln Asn Ser Met Ile Pro 
545                 550                 555                 560 


Ser Phe Gly Lys Val Tyr Lys Lys Gly Tyr Asn Leu Tyr Lys Ser Asp 
                565                 570                 575     


Asn Asn Lys His Lys Gly Leu His Trp Tyr Ile Glu Val Pro Asn Gln 
            580                 585                 590         


Asp Gln Gly Arg Leu Ala Tyr Lys Asn Leu Leu Gln Leu Ile Tyr Tyr 
        595                 600                 605             


Tyr Ala Phe Leu Pro Glu Val Lys Glu Asn Glu Thr Leu Ile Thr Asp 
    610                 615                 620                 


Phe Ile Asn Ser Thr Lys Glu Trp Asn Gln Lys Glu Ala Thr Asn Ala 
625                 630                 635                 640 


Lys Asn Lys Ser Lys Ala Lys Ser Met Gln Ser Asp Glu Ser Asn Asn 
                645                 650                 655     


Ile Ala Tyr Arg Tyr Glu Ala Met Pro Asp Tyr Lys Gly Glu Pro Leu 
            660                 665                 670         


Ser Asp Tyr Leu Glu Leu Leu Gln Arg Glu Gln Met Leu Arg Glu Lys 
        675                 680                 685             


Gln Val Gln Glu Lys Glu Ala Asp Asn Asn Tyr Tyr Ile Pro Phe Ile 
    690                 695                 700                 


Gln Asp Val Val Val Arg Ala Phe Asp Ala Tyr Leu Ser Arg Met Asp 
705                 710                 715                 720 


Lys Tyr Arg Asp Ser Leu Gln Ala Pro Ala Leu Gln Pro Lys Glu Asp 
                725                 730                 735     


Val Glu Lys Ala Leu Asn Glu Leu Ile Cys Ala Asn Gly Gly Lys Tyr 
            740                 745                 750         


Val Leu Lys Thr Arg Phe Gln Lys Tyr Leu Pro Phe Asn Glu Ile Gln 
        755                 760                 765             


Ser Asp Lys Gln Glu Lys Pro Asn Asn Glu Arg Glu Glu Lys Asn Asn 
    770                 775                 780                 


Gln Glu Leu Ser Gln Lys Glu Lys Gly Leu Leu Ser Phe Tyr Leu Leu 
785                 790                 795                 800 


Leu Arg Leu Leu Asp Gly Lys Val Ile Ser Glu Leu Gln His Gln Phe 
                805                 810                 815     


Val Arg Tyr Arg Cys Ser Leu Lys Glu Arg Lys Leu Tyr Asn Tyr Asn 
            820                 825                 830         


Asn Val Asn Gln Asp Glu Leu Ile Ser Ala Leu Glu Glu Leu Glu Glu 
        835                 840                 845             


Leu Met Glu Leu Val Arg Tyr Thr Ile Pro Ser Ala Leu Pro Gln Ser 
    850                 855                 860                 


Leu Ser Gly Lys Lys Glu Ser Asp Phe Lys Asp Leu Ile Glu Arg His 
865                 870                 875                 880 


Phe Asn Asp Phe Phe Glu Glu Lys Val Ile Asn Lys Ile Asp Phe Tyr 
                885                 890                 895     


Tyr Gln Ser Asp Ala Lys Ser Pro Ile Pro Arg Lys Pro Met Thr Leu 
            900                 905                 910         


Leu Val Arg Ser Ala Pro Leu Pro Leu Tyr Gln Gln Met Leu Lys Asp 
        915                 920                 925             


Tyr Tyr His Ile Thr Glu Glu Asp Ile Asn Glu Tyr Leu Lys Leu Ser 
    930                 935                 940                 


Asn Gly Ile Val Asp Glu Gln Asn Arg Leu Asn Glu Leu His Lys Lys 
945                 950                 955                 960 


Leu Glu His Val Lys Val Gln Ser Arg Lys Ile Ser Asn Lys Thr Gly 
                965                 970                 975     


Lys Ser Asn Tyr Val Asn Tyr Leu Thr Glu Glu Asp Ala Gly Met Val 
            980                 985                 990         


Glu Glu Tyr Glu Glu Thr Leu Ile  Lys Val Ile Lys Tyr  Lys Asn Leu 
        995                 1000                 1005             


Arg Arg  Lys Leu Thr Phe Glu  Ser Leu Tyr Glu Ile  Phe Gln Val 
    1010                 1015                 1020             


His Val  Asn Ile Ile Ala Arg  Leu Ile Gly Phe Ala  Glu Asp Trp 
    1025                 1030                 1035             


Glu Arg  Asp Met Phe Phe Leu  Leu Leu Ala Leu Ser  Tyr Gly Lys 
    1040                 1045                 1050             


Tyr Ile  Leu Cys Ser Glu Ser  Asn Val Lys Ala Met  Phe Ser Asn 
    1055                 1060                 1065             


Gly Tyr  Val Val Gly Ala Ile  Thr Lys Lys Asp Gly  Tyr Leu Lys 
    1070                 1075                 1080             


Asn Asp  His Lys Leu Leu Tyr  Glu Leu Cys Trp His  Glu Val Arg 
    1085                 1090                 1095             


Asn Asp  Arg Asp Leu Trp Arg  Ile Met Lys Asp Arg  Leu Asp Ile 
    1100                 1105                 1110             


Arg Asn  Ser Ile Asp His Leu  Asn His Phe Thr Gln  Ser Glu Thr 
    1115                 1120                 1125             


Gly Pro  Leu Pro Ser Leu Glu  Val Thr Leu Asn Lys  Val Arg Asp 
    1130                 1135                 1140             


Met Leu  Cys Tyr Asp Arg Lys  Arg Gln Asn Ala Val  Thr Lys Thr 
    1145                 1150                 1155             


Ile Lys  Asp Met Leu Leu Lys  Glu His His Ile Arg  Ile Glu Trp 
    1160                 1165                 1170             


Glu Ser  Tyr Thr Asp Asn Glu  Lys Lys Tyr Gln Leu  Lys Ile Lys 
    1175                 1180                 1185             


Ser Val  Asn Asp Met Pro Val  Val His Leu Lys His  Leu Arg Ile 
    1190                 1195                 1200             


Asp Gly  Gln Lys Lys Asp Glu  Lys Lys Lys Val Asp  Thr Lys Ala 
    1205                 1210                 1215             


Phe Lys  Tyr Asp Lys Gln Glu  Val Trp Leu His Lys  Gly Val Gln 
    1220                 1225                 1230             


Glu Thr  Ala His Asp Gly Asn  Phe Leu Lys Cys Ile  Asp Arg Leu 
    1235                 1240                 1245             


Leu Thr  Phe Ser Phe Asn Ser  Ala Asn Pro Lys 
    1250                 1255                 


<210>  295
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  295

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  296
<211>  1157
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  296

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Val Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Gly Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Lys Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Val 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Lys Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Asn Tyr Tyr Glu Lys Asp Val Ile Ile Lys Tyr Leu Lys Asn Thr Lys 
    530                 535                 540                 


Phe Asn Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Asn Lys Ile Glu Asp Leu Arg Asn Thr Leu Lys Phe Phe Trp 
                565                 570                 575     


Ser Val Pro Lys Asp Lys Glu Glu Lys Asp Ala Gln Ile Tyr Leu Leu 
            580                 585                 590         


Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn Lys Phe Val Lys Asn Ser 
        595                 600                 605             


Lys Val Phe Phe Lys Ile Thr Asn Glu Val Ile Lys Ile Asn Lys Gln 
    610                 615                 620                 


Arg Asn Gln Lys Thr Gly His Tyr Lys Tyr Gln Lys Phe Glu Asn Ile 
625                 630                 635                 640 


Glu Lys Thr Val Pro Val Glu Tyr Leu Ala Ile Ile Gln Ser Arg Glu 
                645                 650                 655     


Met Ile Asn Asn Gln Asp Lys Glu Glu Lys Asn Thr Tyr Ile Asp Phe 
            660                 665                 670         


Ile Gln Gln Ile Phe Leu Lys Gly Phe Ile Asp Tyr Leu Asn Lys Asn 
        675                 680                 685             


Asn Leu Lys Tyr Ile Glu Asn Asn Asn Asn Asn Asp Asn Asn Asp Ile 
    690                 695                 700                 


Phe Ser Lys Ile Lys Ile Lys Lys Asp Asn Lys Glu Lys Tyr Asp Lys 
705                 710                 715                 720 


Ile Leu Lys Asn Tyr Glu Lys His Asn Arg Asn Lys Glu Ile Pro His 
                725                 730                 735     


Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly Lys Ile Leu Lys 
            740                 745                 750         


Tyr Thr Glu Ser Leu Asn Met Phe Tyr Leu Ile Leu Lys Leu Leu Asn 
        755                 760                 765             


His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu Lys Tyr Gln Ser 
    770                 775                 780                 


Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu Leu Ile Asn Leu 
785                 790                 795                 800 


Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe Glu Leu Glu Ala 
                805                 810                 815     


Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Glu Asn Lys Ile Lys Asp 
            820                 825                 830         


Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile Tyr Phe Asp Gly 
        835                 840                 845             


Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile Lys Lys Tyr Gly 
    850                 855                 860                 


Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala Lys Tyr Lys Ile 
865                 870                 875                 880 


Ser Leu Lys Glu Leu Lys Glu Tyr Ser Asn Lys Lys Asn Glu Ile Glu 
                885                 890                 895     


Lys Asn Tyr Thr Met Gln Gln Asn Leu His Arg Lys Tyr Ala Arg Pro 
            900                 905                 910         


Lys Lys Asp Glu Lys Phe Asn Asp Glu Asp Tyr Lys Glu Tyr Glu Lys 
        915                 920                 925             


Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys Asn Lys Val Glu 
    930                 935                 940                 


Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu Lys Ile Leu His 
945                 950                 955                 960 


Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp Leu Arg Phe Arg 
                965                 970                 975     


Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu Glu Ile Phe Asn 
            980                 985                 990         


Phe Asp Asn Ser Lys Asn Val Lys  Tyr Lys Ser Gly Gln  Ile Val Glu 
        995                 1000                 1005             


Lys Tyr  Ile Asn Phe Tyr Lys  Glu Leu Tyr Lys Asp  Asn Val Glu 
    1010                 1015                 1020             


Lys Arg  Ser Ile Tyr Ser Asp  Lys Lys Val Lys Lys  Leu Lys Gln 
    1025                 1030                 1035             


Glu Lys  Lys Asp Leu Tyr Ile  Arg Asn Tyr Ile Ala  His Phe Asn 
    1040                 1045                 1050             


Tyr Ile  Pro His Ala Glu Ile  Ser Leu Leu Glu Val  Leu Glu Asn 
    1055                 1060                 1065             


Leu Arg  Lys Leu Leu Ser Tyr  Asp Arg Lys Leu Lys  Asn Ala Val 
    1070                 1075                 1080             


Met Lys  Ser Val Val Asp Ile  Leu Lys Glu Tyr Gly  Phe Val Ala 
    1085                 1090                 1095             


Lys Phe  Lys Ile Gly Ala Asp  Lys Lys Ile Gly Ile  Gln Thr Leu 
    1100                 1105                 1110             


Glu Ser  Glu Lys Ile Val His  Leu Lys Asn Leu Lys  Lys Lys Lys 
    1115                 1120                 1125             


Leu Met  Thr Asp Arg Asn Ser  Lys Glu Leu Cys Glu  Leu Val Lys 
    1130                 1135                 1140             


Val Met  Phe Glu Tyr Lys Met  Glu Glu Lys Lys Ser  Glu Asn 
    1145                 1150                 1155         


<210>  297
<211>  1141
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  297

Met Lys Ile Thr Lys Ile Asp Gly Ile Ser His Lys Lys Tyr Lys Glu 
1               5                   10                  15      


Lys Gly Lys Leu Ile Lys Ser Asn Glu Ile Glu Lys Asp Ile Thr Glu 
            20                  25                  30          


Glu Arg Phe Asn Asp Ile Glu Ala Lys Thr Thr Glu Leu Phe Gln Lys 
        35                  40                  45              


Thr Leu Asp Phe Tyr Val Lys Asn Tyr Glu Asn Ser Glu Asp Gln Asn 
    50                  55                  60                  


Lys Glu Arg Arg Glu Lys Ala Lys Asn Tyr Phe Ser Lys Val Lys Ile 
65                  70                  75                  80  


Leu Val Asp Asn Lys Lys Ile Thr Ile Cys Asn Glu Asn Thr Glu Lys 
                85                  90                  95      


Met Glu Ile Glu Asp Phe Asn Glu Tyr Asp Val Arg Asn Arg Lys Phe 
            100                 105                 110         


Phe Asn Val Leu Asn Lys Ile Leu Asn Arg Glu Asn Cys Thr Glu Glu 
        115                 120                 125             


Asp Leu Glu Val Phe Glu Asn Asp Leu Gln Lys Arg Ile Gly Arg Ile 
    130                 135                 140                 


Lys Ser Ile Lys Asn Ser Leu Glu Glu Asn Lys Ala His Phe Lys Lys 
145                 150                 155                 160 


Glu Ser Ile Asn Asn Asn Ile Asn Tyr Asp Lys Val Lys Gly Asn Asn 
                165                 170                 175     


Lys Arg Ser Ile Phe Tyr Glu Tyr Tyr Lys Asn Ser Leu Lys His Gln 
            180                 185                 190         


Glu Tyr Ile Asn Asn Ile Phe Glu Ala Phe Asp Lys Leu Tyr Ser Asn 
        195                 200                 205             


Ser His Glu Ala Met Asn Asn Leu Phe Ser Glu Ile Thr Lys Asp Ser 
    210                 215                 220                 


Lys Asp Arg Asn Ile Arg Lys Ile Arg Glu Ala Tyr His Glu Ile Leu 
225                 230                 235                 240 


Asn Lys Asn Lys Thr Glu Phe Gly Glu Glu Leu Tyr Lys Lys Ile Gln 
                245                 250                 255     


Asp Asn Arg Asn Asn Phe Asp Lys Leu Leu Glu Ile Glu Pro Glu Ile 
            260                 265                 270         


Lys Glu Leu Thr Lys Ser Gln Ile Phe Tyr Lys Tyr Tyr Ile Asp Lys 
        275                 280                 285             


Val Asn Leu Asp Glu Thr Ser Ile Lys His Cys Phe Cys His Leu Val 
    290                 295                 300                 


Glu Ile Glu Val Asn Gln Leu Leu Lys Asn Tyr Val Tyr Ser Lys Arg 
305                 310                 315                 320 


Asn Ile Asn Lys Glu Lys Leu Glu Asn Ile Phe Glu Tyr Cys Lys Leu 
                325                 330                 335     


Arg Asn Leu Val Lys Asn Lys Leu Val Asn Lys Leu Asn Asn Tyr Ile 
            340                 345                 350         


Arg Asn Cys Gly Lys Tyr Asn Ala Tyr Ile Ser Asn Asn Asp Val Val 
        355                 360                 365             


Val Asn Ser Glu Lys Ile Ser Glu Ile Arg Thr Lys Glu Ala Phe Leu 
    370                 375                 380                 


Arg Ser Ile Ile Gly Val Ser Ser Ser Ala Tyr Phe Ser Leu Arg Asn 
385                 390                 395                 400 


Ile Leu Asn Thr Asp Asn Thr Gln Asp Ile Thr Asn Lys Val Asp Lys 
                405                 410                 415     


Glu Val Asp Lys Leu Tyr Gln Glu Asn Lys Lys Ile Glu Leu Glu Glu 
            420                 425                 430         


Ile Leu Lys Leu Phe Phe Gly Asn Tyr Phe Asp Ile Asn Asn Gln Gln 
        435                 440                 445             


Glu Ile Lys Val Phe Leu Met Asn Ile Asp Lys Ile Ile Ser Ser Ile 
    450                 455                 460                 


Arg His Glu Ile Ile His Phe Lys Met Glu Thr Asn Ala Gln Asn Ile 
465                 470                 475                 480 


Phe Asp Phe Asn Asn Val Asn Leu Gly Asn Thr Ala Lys Asn Ile Phe 
                485                 490                 495     


Ser Asn Glu Ile Asn Glu Glu Lys Ile Lys Phe Lys Ile Phe Lys Gln 
            500                 505                 510         


Leu Asn Ser Ala Asn Val Phe Asp Tyr Leu Ser Asn Lys Asp Ile Thr 
        515                 520                 525             


Glu Tyr Met Asp Lys Val Val Phe Ser Phe Thr Asn Arg Asn Val Ser 
    530                 535                 540                 


Phe Val Pro Ser Phe Thr Lys Ile Tyr Asn Arg Val Gln Asp Leu Ala 
545                 550                 555                 560 


Asn Ser Leu Glu Ile Lys Glu Trp Lys Ile Pro Asp Glu Ser Glu Gly 
                565                 570                 575     


Lys Asp Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Lys Phe 
            580                 585                 590         


Leu Asp Lys Phe Leu Asn Glu Glu Asn Gly Ile Phe Ile Ser Ile Lys 
        595                 600                 605             


Asp Lys Ile Thr Gly Phe Tyr Lys Leu Glu Lys Phe Glu Lys Ile Glu 
    610                 615                 620                 


Glu Thr Asn Pro Lys Lys Tyr Leu Glu Ile Ile Gln Ser Leu Tyr Met 
625                 630                 635                 640 


Ile Asn Ile Glu Glu Ile Asp Ser Glu Gly Lys Asn Ile Phe Leu Asp 
                645                 650                 655     


Phe Ile Gln Lys Ile Phe Leu Lys Gly Phe Phe Glu Phe Ile Lys Asn 
            660                 665                 670         


Asp Tyr Asn Tyr Leu Leu Glu Leu Lys Lys Val Gln Asp Lys Lys Asn 
        675                 680                 685             


Ile Phe Asp Ser Lys Met Ser Glu Tyr Ile Ala Gly Glu Lys Thr Leu 
    690                 695                 700                 


Glu Asp Met Glu Glu Ile Asn Glu Ile Ile Gln Asp Ile Lys Ile Thr 
705                 710                 715                 720 


Glu Ile Asp Lys Ile Leu Asn Gln Thr Asp Lys Ile Asn Cys Phe Tyr 
                725                 730                 735     


Leu Leu Leu Lys Leu Leu Asn Tyr Lys Glu Ile Thr Glu Leu Lys Gly 
            740                 745                 750         


Asn Leu Glu Lys Tyr Gln Ile Leu Ser Lys Thr Asn Val Tyr Glu Lys 
        755                 760                 765             


Glu Leu Met Leu Leu Asn Ile Val Asn Leu Asp Asn Asn Lys Val Lys 
    770                 775                 780                 


Ile Glu Asn Phe Lys Ile Ser Ala Glu Glu Ile Gly Lys Phe Ile Glu 
785                 790                 795                 800 


Lys Ile Asn Ile Glu Glu Ile Asn Lys Lys Ile Lys Thr Phe Gly Glu 
                805                 810                 815     


Leu Arg Asn Phe Glu Lys Gly Glu Asn Thr Gly Glu Tyr Tyr Asn Ile 
            820                 825                 830         


Tyr Ser Asp Asp Lys Asn Ile Lys Asn Ile Arg Asn Leu Tyr Asn Ile 
        835                 840                 845             


Lys Lys Tyr Gly Met Leu Asp Leu Leu Glu Lys Ile Ser Glu Lys Thr 
    850                 855                 860                 


Asn Tyr Cys Ile Lys Lys Lys Asp Leu Lys Glu Tyr Ser Lys Leu Arg 
865                 870                 875                 880 


Lys Gln Leu Glu Asp Lys Lys Lys Glu Asn Glu Lys Ile Glu Asp Glu 
                885                 890                 895     


Lys Thr Asn Phe Tyr Lys Ile Gln Glu Tyr Leu His Ser Lys Tyr Gln 
            900                 905                 910         


Gln Glu Pro Lys Lys Ile Leu Trp Lys Lys Asn Lys Asn Asp Tyr Glu 
        915                 920                 925             


Lys Tyr Lys Lys Ser Ile Glu Asn Ile Glu Lys Tyr Val His Leu Lys 
    930                 935                 940                 


Asn Lys Ile Glu Phe Asn Glu Leu Asn Leu Leu Gln Ser Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Ala Gly Phe Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Thr Gly Glu Phe Pro Asp Glu Leu Asp Val Glu 
            980                 985                 990         


Asp Ile Phe Asn His Arg Lys Arg  Tyr Lys Gly Thr Gly  Lys Gly Ile 
        995                 1000                 1005             


Cys Lys  Lys Tyr Asp Arg Phe  Ile Asn Thr His Thr  Glu Tyr Lys 
    1010                 1015                 1020             


Asn Asn  Asn Lys Met Lys Asn  Val Lys Phe Val Asp  Asp Asn Pro 
    1025                 1030                 1035             


Val Arg  Asn Tyr Ile Ala His  Phe Asn Tyr Leu Pro  Thr Pro Lys 
    1040                 1045                 1050             


Tyr Ser  Ile Leu Lys Met Met  Glu Lys Leu Arg Lys  Leu Leu Asp 
    1055                 1060                 1065             


Tyr Asp  Arg Lys Leu Lys Asn  Ala Val Met Lys Ser  Ile Lys Asp 
    1070                 1075                 1080             


Ile Leu  Glu Glu Tyr Gly Phe  Lys Ala Glu Phe Ile  Ile Asn Ser 
    1085                 1090                 1095             


Asp Lys  Glu Ile Ile Leu Asn  Ser Val Lys Ser Val  Glu Ile Ile 
    1100                 1105                 1110             


His Leu  Gly Lys Glu Asp Leu  Lys Ser His Arg Asn  Ser Glu Asp 
    1115                 1120                 1125             


Leu Cys  Lys Leu Val Lys Ala  Met Leu Glu Tyr Ser  Glu 
    1130                 1135                 1140     


<210>  298
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  298

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Ala Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  299
<211>  1357
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  299

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Thr Glu Asn Lys Asn Glu Glu Gln Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Lys Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Arg Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Leu Lys Lys Asn Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Ser Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Cys Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Thr Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Ile Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Gln Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Lys 
                405                 410                 415     


Arg Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Ile Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Ala Leu Glu Gly Glu Ser 
    450                 455                 460                 


Val Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Glu Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Ala Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Arg Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Lys Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Lys Gly Asp Lys Glu Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Glu Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Ser Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Lys Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Ala Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Val Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Glu Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Met Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Val Leu Val Pro Ala  Arg Ser Glu 
    1325                 1330                 1335             


Val Phe  Leu Lys Gln Phe Arg  Lys Ile Leu Glu Tyr  Arg Ile Gln 
    1340                 1345                 1350             


Asp Lys  Thr Gln 
    1355         


<210>  300
<211>  1318
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  300

Val Ala Val Val Leu Asn Pro Asp Val Val Arg Arg Ser Arg Asp Tyr 
1               5                   10                  15      


Ile Thr Leu Ile Ser Arg Met Ser Ser Met Arg Leu Thr Asp Pro Glu 
            20                  25                  30          


Pro Pro Leu Glu Thr Ala Ser Arg Ser Arg Arg Leu Val Ser Arg Arg 
        35                  40                  45              


Leu Phe Lys Gly Leu Arg Val Ala Gly Arg Glu Asp Arg Cys Val Arg 
    50                  55                  60                  


Ala Thr Ser Asp His Ser Thr Ala Gly Ser Met Ile Arg Tyr Pro His 
65                  70                  75                  80  


Val Phe Gly Glu Gly Ser Met Gln Ile Ile Arg Pro Tyr Gly Ser Ser 
                85                  90                  95      


Arg Ser Lys Gln Gly Gln Asp Gly Leu Arg Arg Val Leu Val Glu Lys 
            100                 105                 110         


Thr Ser Gly Arg Ala Glu Gln Asp Ile Pro Thr Tyr Ala Arg Thr His 
        115                 120                 125             


Glu Glu Leu Val Ile Ala Gln Trp Ile Ser Thr Ile Asp Lys Ile Ala 
    130                 135                 140                 


Arg Lys Pro Thr Ser Arg Lys Lys Pro Ser Ala Asp Gln Arg Ala Phe 
145                 150                 155                 160 


Arg Asp Lys Leu Gly Asn Ala Cys Trp Val Arg Leu Met Gly Ser Gly 
                165                 170                 175     


Arg Leu Lys Asp Ile Asn Asp Ala Arg Arg Ala Tyr Leu Ser Asp Leu 
            180                 185                 190         


Trp Trp Phe Lys Ile His Pro Tyr Glu Leu Gly Ile Asp Glu Pro Arg 
        195                 200                 205             


Pro Arg Arg Asp Gly Ser Met Pro Ala Ala Pro Lys Val Glu Gly Arg 
    210                 215                 220                 


Trp Tyr Lys Val Phe Ala Gly Asp Gly Ala Pro Gln Met Ser Gly Pro 
225                 230                 235                 240 


Glu Lys Ile Ala Glu Ile Ala Glu Arg Ile Glu Arg His Leu Tyr Glu 
                245                 250                 255     


Ser Glu Arg Arg Leu Gly Pro Asp Ala Arg Pro Arg Lys Leu Gly Lys 
            260                 265                 270         


Ile Glu Ser Arg Ala Glu Ser Ile Ser Gly Ser Val Leu Arg Met Ala 
        275                 280                 285             


Asn Gly Ala His Thr Glu Gln Pro Gly Trp Ser Lys Asp Asp Glu Arg 
    290                 295                 300                 


Ala Tyr Thr Glu Thr Gly Asp Pro Val Val Ser Ile Arg Val Glu Ala 
305                 310                 315                 320 


Glu Ser Thr Glu Arg Asn Lys Gly Arg Ala Ser Leu Pro Leu Ala Ala 
                325                 330                 335     


Glu Val Leu Phe Lys His Trp Gly Lys Val Phe Leu Asp Pro Asp Thr 
            340                 345                 350         


Gly Thr Ala Met Ser Tyr Ile Ala Ala Gln Ala Lys His Pro Gly Met 
        355                 360                 365             


Val Ala Leu His Met Glu Leu Lys Gln Cys Tyr Arg Arg Leu Leu Lys 
    370                 375                 380                 


Arg Thr Arg Lys Asp Thr Arg Glu His Arg Lys Arg Asp Pro Asp Glu 
385                 390                 395                 400 


Arg Lys Leu Ser Arg Leu Leu Pro Arg Asn Leu Ala Glu Ala Leu Ser 
                405                 410                 415     


Leu Ser Ala Lys Gln Asp Ala Asn Ala Glu Leu Gly His Leu Val Arg 
            420                 425                 430         


Leu Gly Lys Val Ile Tyr Tyr Thr Ala Ser Asp Gly Glu Ala Asp Cys 
        435                 440                 445             


Ala Gly Ala Ile Gly Arg Asn Trp Pro Asp Lys Val Glu Thr Ser Arg 
    450                 455                 460                 


Phe Trp Ser Ser Glu Gly Gln Ala Glu Ile Lys Arg Ala Glu Ala Phe 
465                 470                 475                 480 


Val Arg Ile Trp Arg His Ala Leu Val Leu Gly Gly Leu Thr Leu Lys 
                485                 490                 495     


Asp Trp Val Ser Met Lys Glu Pro Phe Pro Gly Asp Ile Leu Gly Gly 
            500                 505                 510         


Asp Arg Gln Leu Thr Ser Ala Leu Ala Pro Glu Arg Phe Asp Arg Gly 
        515                 520                 525             


Pro Phe Asp Arg Lys Leu Gln Leu Leu Phe Gly Asn Arg Ser Asn Ala 
    530                 535                 540                 


Phe Val Phe Ala Asp Asp Gly Gln Arg Leu Asp Leu Leu Arg Gly Leu 
545                 550                 555                 560 


Ile Gly Gly Ala Ala Asn Leu Arg His Ala Ala Phe His Phe Lys Gly 
                565                 570                 575     


Arg Gly Gln Leu Leu Arg Ala Leu Ala Glu Leu Pro Gly Lys Phe Ser 
            580                 585                 590         


Asn Arg Leu Gln Glu Ala Ala Arg Gly Leu Trp Arg Asp Asp Ala Ser 
        595                 600                 605             


His Arg Ala Asp Arg Leu Lys Ala Thr Leu Arg Gly Val His Ile Glu 
    610                 615                 620                 


His Phe Val Thr Lys Glu Gln Ala Glu Gln Ala Leu Ala Leu Leu Leu 
625                 630                 635                 640 


Glu Glu Ala Arg Ala Glu Leu Pro Leu Pro Arg Leu Ser Arg Val Leu 
                645                 650                 655     


Leu Arg Ala Glu Asn Ala Trp Gly Arg Asp Asp Ala Val Lys Leu Pro 
            660                 665                 670         


Glu Pro Ala Asn Arg Arg Ala Leu Glu Ala Pro Pro Arg Gln Cys Gln 
        675                 680                 685             


Tyr Thr Leu Leu Lys Leu Ile Tyr Glu Arg Pro Phe Arg Ser Trp Leu 
    690                 695                 700                 


Arg Asp Arg Arg Ala Asp Val Val Ser Gln Trp Ile Asp Arg Ala Val 
705                 710                 715                 720 


Ala Arg Ala Thr Arg Ala Ala Lys Thr Ile Asn Ala Lys Gly Asp Asp 
                725                 730                 735     


Val Ala Arg Arg Met Ile Ala Ala Lys Ala Glu Lys Leu Pro Lys Pro 
            740                 745                 750         


Ala Ala Gly Ser Asp Met Ile Asp Phe Phe Phe Asp Leu Ser Ala Ala 
        755                 760                 765             


Thr Ala Gly Glu Met Arg Val Gln Arg Gly Tyr Glu Ser Asp Arg Glu 
    770                 775                 780                 


Gln Ala Arg Asp Gln Ala Asp His Ile Asp Gln Leu Leu Cys Asp Val 
785                 790                 795                 800 


Val Ile Leu Ala Phe Asn Glu Tyr Leu Ser Glu Arg Gln Leu Asp Trp 
                805                 810                 815     


Ile Leu Thr Leu Lys Ala Asp Gln Pro Val Thr Gly Glu Arg Ala Phe 
            820                 825                 830         


Ser Leu Asp Asp Leu Gln Thr Val Ala Met Pro Val Glu Asp Val Asp 
        835                 840                 845             


Asp Trp Gln Val Ala Leu Tyr Leu Leu Leu His Leu Leu Pro Val Glu 
    850                 855                 860                 


Ala Val Ala Lys Leu Leu His Gln Leu Phe Lys Trp Asp Ile Thr Ala 
865                 870                 875                 880 


Thr Arg Glu Gly Arg Leu Pro Arg Asp Glu Ser Gln Arg Leu His Arg 
                885                 890                 895     


Leu Phe Ala Thr Leu Thr Leu Tyr Leu Asp Met His Asp Ala Lys Tyr 
            900                 905                 910         


Glu Gly Gly Ser Pro Leu Ala Glu Tyr Ala Asp Val Gln Glu Leu Phe 
        915                 920                 925             


Ala Thr Ala Arg Gly Phe Gly Arg Val Phe Pro Ser Asp Ala Ser Leu 
    930                 935                 940                 


Glu Ala Asp Arg Arg Ile Pro Lys Arg Gly Leu Arg Glu Ile Leu Arg 
945                 950                 955                 960 


Leu Gly His Leu Pro Leu Val Lys Ala Ile Ala Gly Gly Arg Arg Ile 
                965                 970                 975     


Glu Glu Ala Thr Ile Asp Arg Val Phe Ala Phe Glu Thr Thr Pro Asp 
            980                 985                 990         


Gly Gly Gly Leu Thr Pro Ile Ala  Ala Leu Gln Gln Arg  Arg Glu Glu 
        995                 1000                 1005             


Leu His  Asp Arg Trp Val Arg  Gln Lys Asn Leu Asp  Glu Tyr Asp 
    1010                 1015                 1020             


Leu Arg  Glu Tyr Cys Glu Ala  Val Ser Lys Ile Ser  Gly His Arg 
    1025                 1030                 1035             


Gln Asp  Ser Asn Phe Met Asn  Leu Val Asp His Val  Arg Ala His 
    1040                 1045                 1050             


Arg Thr  Ile Leu Ser Val Leu  Gly Arg Leu Val Asp  Tyr Val Gly 
    1055                 1060                 1065             


Leu Phe  Glu Arg Asp Leu Tyr  Phe Thr Thr Leu Ala  Leu Ile Lys 
    1070                 1075                 1080             


Leu His  Asp Glu Arg Pro Asp  Ala Ile Phe Asp Glu  Arg Gly Leu 
    1085                 1090                 1095             


Arg Leu  Phe His Asn Gly Gln  Ile Ile Phe Ala Leu  Gly Ala Leu 
    1100                 1105                 1110             


Arg Gly  Gly Ser Ala Lys Val  Ala Ala Ile Lys Gly  Asn Leu Ala 
    1115                 1120                 1125             


Arg His  Phe Thr Glu Val Trp  Val Gln Asn Asn Asp  Ala Lys Asp 
    1130                 1135                 1140             


Ile Arg  Asn Asp Leu Ala His  Leu Asn Met Leu Gln  Gly Ala His 
    1145                 1150                 1155             


Pro Val  Pro Lys Leu Thr Tyr  Trp Ile Asn Gln Thr  Arg Gln Leu 
    1160                 1165                 1170             


Met Gly  Tyr Asp Arg Lys Leu  Lys Asn Ala Val Ser  Lys Ser Ile 
    1175                 1180                 1185             


Ile Asp  Leu Ile Asp Arg Glu  Gly Ile Glu Leu Lys  Trp Ala Met 
    1190                 1195                 1200             


Arg Val  Glu Arg Gly Ser His  Asp Leu Ala Asp Ala  Thr Leu Ala 
    1205                 1210                 1215             


Ala Arg  Ser Ala Lys His Leu  Gly Lys Lys Gln Leu  Thr Leu Asp 
    1220                 1225                 1230             


Gly Ser  Ser Gly Arg Ser Arg  Leu Thr Leu Glu Glu  Ser Leu His 
    1235                 1240                 1245             


Gly Leu  Gly Phe Val Thr Met  Ile Ala Thr Ser Phe  Glu Gly Lys 
    1250                 1255                 1260             


Ala Gln  Ala Val Ala Ser Ile  Gly Asp His Leu Pro  Lys Val Asp 
    1265                 1270                 1275             


Trp Lys  Thr Ser Ala Gln Arg  Gly Pro Arg His Gly  Ser Gly Gln 
    1280                 1285                 1290             


Gly Arg  Ser Gln Arg Pro Ser  Ser Gly Gly Lys Lys  Phe Arg Pro 
    1295                 1300                 1305             


Ser Ser  Thr Arg Asn Glu Thr  Gly Arg Arg 
    1310                 1315             


<210>  301
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  301

Met Lys Leu Ser Lys Glu Lys Tyr Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Glu Tyr Ile Arg Ser Ala Val Ala Asn Glu Lys Gln 
        35                  40                  45              


Asn Ile Gly Gly Val Leu Tyr His Ala His Gly Thr Asp Thr Ile Asp 
    50                  55                  60                  


Leu Gln Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Gly Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Thr Asp Arg Val Arg Arg Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Ile Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Glu Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Tyr Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Leu Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Glu Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Ile Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Ile Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1400                 1405                 1410         


<210>  302
<211>  1221
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  302

Met Met Gln Ile Ile Lys Pro Tyr Gly Arg Ser Val Val Asp Thr Gly 
1               5                   10                  15      


Thr Gly Glu Pro Thr Gln Arg Lys Leu Gln Asp Lys Asn Gln Gln Gln 
            20                  25                  30          


His Asp Ile Ser Gln Phe Val His Glu His Ala Glu Leu Val Val Ala 
        35                  40                  45              


Gln Trp Ile Ser Val Ile Asp Lys Ile Ala Arg Lys Pro His Ala Asn 
    50                  55                  60                  


Gly Lys Asn Ala Gly Lys Cys Gly Leu Pro Thr Ala Gly Gln Tyr Gln 
65                  70                  75                  80  


Leu Arg Asp Ile Leu Gly Thr Ala Ala Trp Val Glu Val Leu Lys His 
                85                  90                  95      


Leu Ser Pro Gly Met Asp Ala Gln Arg Gln Gln Tyr Leu Glu Thr Leu 
            100                 105                 110         


Trp Tyr Ser Lys Ile His Pro Tyr Gly Lys Gln Thr Gln Glu Gln Glu 
        115                 120                 125             


Lys Ala Ile Pro Leu Gln Gly Arg Trp Tyr Gln Arg Phe Val Gly Asp 
    130                 135                 140                 


Val Leu Pro Glu Asn Val Asp Val Ala Leu Ala Lys Gln Val Ala Glu 
145                 150                 155                 160 


Arg Ile His Leu His Leu Tyr Glu Ala Ala Leu Arg Ile Asn Pro Glu 
                165                 170                 175     


Val Ser Ala Arg Arg Lys Gly Ser Ile Gln Ala Gln Ala Glu Thr Ile 
            180                 185                 190         


Thr Asn Asn Thr Leu His Pro Val Val Pro Pro Met Thr Trp Ser Lys 
        195                 200                 205             


Ala Asp Trp Ser Ala Tyr Asn Arg Tyr Asp Val Ala Glu Arg Ile Tyr 
    210                 215                 220                 


Leu Glu Ala Lys Tyr Arg Leu Glu Gln Lys Gln Asp Ala Arg Gln Lys 
225                 230                 235                 240 


Lys Gln Pro Ile Gln Pro Glu Trp Arg Ile Asp Gly Ser Leu Ala Gly 
                245                 250                 255     


Lys Leu Leu Phe Glu His Trp Ala Gln Val Phe Lys Gly Ser Asp Gly 
            260                 265                 270         


Lys Ser Arg Ile Ser Glu Ala Lys Thr His Ala Ala Gly Leu Phe Ala 
        275                 280                 285             


Leu His Met Ala Val Lys Asp Phe Tyr Thr Arg Leu Phe Asp Ser Asn 
    290                 295                 300                 


Arg Lys Glu Glu Thr Leu Val Lys Phe Leu Leu Pro Gln Lys Lys Lys 
305                 310                 315                 320 


Ala Leu Gln Glu Lys Leu Thr Gln Lys Leu Gln Asn Thr Asp Val Ala 
                325                 330                 335     


Ala Arg Ile Arg Leu Gly Lys Ile Gln Tyr Tyr Arg Lys Ala Gln Gly 
            340                 345                 350         


Glu Val Val Pro Leu Ala Asn Ser Arg Phe Trp Gly Ser Asp Gly Gln 
        355                 360                 365             


Ala Glu Ile Lys Arg Ala Glu Ala Phe Val Arg Val Trp Arg His Val 
    370                 375                 380                 


Leu Gly Gln Ala Asn Leu Thr Leu Ala Asn Trp Ala Ser Leu Ala Ser 
385                 390                 395                 400 


Pro Ala Asp Leu Trp Gly Gly Asp Ser Phe Phe Gly His Phe Ser Thr 
                405                 410                 415     


His Ile Asn Gly Lys Leu Phe Ala Thr Asp Ile Gly Leu Asp Ser Arg 
            420                 425                 430         


Arg Thr Val Phe Asp Gln Asn Leu His Leu Leu Phe Gly Asp Ala Ala 
        435                 440                 445             


Gly Leu Phe Gln Ser Asp Asp Glu Thr Arg Lys Ala Ser Ile Leu Leu 
    450                 455                 460                 


Ala His Lys Cys Gly Gly Ala Leu Arg Asn Ala Ala Phe His Phe Lys 
465                 470                 475                 480 


Gly Arg Ala Lys Phe Leu Gln Ala Leu Glu Asn Asp Leu Pro Gln Ala 
                485                 490                 495     


Ala Gln Ser Gly Leu Gln Met Gln Leu Ser Lys Leu Trp Asp Glu Ala 
            500                 505                 510         


Gln Asn Gln Gln Gly Ser Arg Leu Leu Lys Ile Leu Glu Gly Ala His 
        515                 520                 525             


Val Phe His Val Cys Thr Gln Glu Gln Val Gln Gln Leu Val Asn Thr 
    530                 535                 540                 


Leu Gly Asn Val Ser Ala Gly Glu Leu Pro Leu Pro Arg Phe Gly Arg 
545                 550                 555                 560 


Val Ile Glu Arg Asn His His Ala Arg Leu Gly Thr Asn Leu Pro Val 
                565                 570                 575     


Arg Gly Asn Arg Gln Ala Met Glu Gln His Pro Ala Arg Lys Cys Gln 
            580                 585                 590         


Tyr Val Met Leu Lys Leu Leu Tyr Glu Arg Ala Phe Arg Val Trp Leu 
        595                 600                 605             


Glu Asn Thr Thr Asp Glu Val Phe Ser Val Trp Leu Glu Thr Ala Leu 
    610                 615                 620                 


Glu Arg Thr Thr Asn Ala Ala Arg Asn Asn Pro Asn Val Gln Gly Lys 
625                 630                 635                 640 


Ser Gln His Glu Arg Glu Leu Val Met Ala Arg Ala Ala Lys Leu Pro 
                645                 650                 655     


Ile Ser Met Arg Ser Lys Gly Gly Lys Gly Lys Glu Lys Ser Ile Arg 
            660                 665                 670         


Gln Phe Phe Tyr Asp Leu Ser Ala Ala Thr Ala Ser Glu Met Arg Val 
        675                 680                 685             


Gln Arg Gly Tyr Ala Ser Asp Ala Gly Lys Ala Arg Glu Gln Ala Glu 
    690                 695                 700                 


Tyr Ile Asp Glu Leu Leu Arg Asp Val Val Ala Leu Ala Phe Arg Glu 
705                 710                 715                 720 


Phe Ile Arg Ala Asn Gly Phe Asp Trp Leu Leu Asp Ile Asp Pro Gln 
                725                 730                 735     


Gln Glu Leu Arg Glu Thr Arg Cys Cys Leu Met Glu His Ile Arg Phe 
            740                 745                 750         


Pro Ala Ile Ala Pro Arg Ser Asn Ala Trp Gln Pro Val Leu Tyr Phe 
        755                 760                 765             


Leu Leu His Leu Met Pro Val Gly Glu Val Ser Gln Leu Leu His Gln 
    770                 775                 780                 


Leu Ala Lys Trp Glu Ile Leu Ala Lys Pro Glu Gln Ala Arg Thr Asp 
785                 790                 795                 800 


Glu Glu Gly Met Arg Leu His Ala Leu Gln Gln Thr Leu Lys Leu Tyr 
                805                 810                 815     


Leu Asp Met His Asp Ser His Tyr Thr Gly Ala Glu Ser Met Pro Ala 
            820                 825                 830         


Val Glu Arg Ala Val Leu Asp Thr Phe Ala Thr Phe Tyr Glu Thr Arg 
        835                 840                 845             


Asn Gly Leu Asp Lys Val Phe Glu Asp Gln Gly Asn Gly Arg Asp Gly 
    850                 855                 860                 


Ala Arg Tyr Leu Pro Gln Arg Gly Leu Arg Glu Ile Arg Arg Phe Gly 
865                 870                 875                 880 


His Val Pro Val Leu Gln Ala Leu Val Lys Asp Lys Ile Thr Ala Gln 
                885                 890                 895     


Asp Val Thr His Cys Leu Gln Gln Glu Thr Val Pro Ala Asn Gly Lys 
            900                 905                 910         


Leu Ser Pro Val Ala Gln Ala Gln Gln Arg Arg Glu Thr Leu His Gly 
        915                 920                 925             


Glu Trp Val Lys Glu Arg Lys Gln Phe Lys Ala Tyr Arg Asp Tyr Ala 
    930                 935                 940                 


Ala Ala Leu Gln Thr Val Val Val His Arg Gln Leu Ser Asn His Ile 
945                 950                 955                 960 


Arg Leu Val Asp His Val Ala Ala His Arg Ile Val Met Lys Val Leu 
                965                 970                 975     


Ala Arg Leu Ala Asp Phe Ser Gly Leu Phe Glu Arg Asp Leu Thr Phe 
            980                 985                 990         


Val Thr Leu Ala Ala Leu His Glu  His Gln Leu Gln Pro  Glu Asp Phe 
        995                 1000                 1005             


Phe Val  Ile Asp Asn Pro Pro  Arg Tyr Asn Asn Arg  Gly Glu Leu 
    1010                 1015                 1020             


Glu Lys  Asp Gly Leu Thr Leu  Phe Lys Asn Gly Gln  Val Ile Glu 
    1025                 1030                 1035             


Ala Leu  Gly Lys Val Gln Ala  Cys Arg Asp Ala Leu  Lys His Gln 
    1040                 1045                 1050             


Ile Val  Gly Gln Val Asn Leu  Asp Val His Arg Ser  Val Arg Asn 
    1055                 1060                 1065             


Asp Phe  Ala His Phe Asn Met  Leu Tyr Gly Lys Gln  Arg Thr Thr 
    1070                 1075                 1080             


Glu Ser  Ala Thr Asn Arg Val  Ile Lys Cys Pro Ala  Ala Gln Gly 
    1085                 1090                 1095             


Leu Asn  Leu Thr Cys Trp Val  Asn Cys Ala Arg Asn  Leu Met Ser 
    1100                 1105                 1110             


Tyr Asp  Arg Lys Leu Lys Asn  Ala Val Ser Gln Ser  Ile Ile Glu 
    1115                 1120                 1125             


Leu Met  Glu Arg Glu Gly Phe  Ile Leu Thr Trp Glu  Met Asp Thr 
    1130                 1135                 1140             


Asn His  Gln Leu Cys Ser Pro  Lys Leu Gln Ser Arg  Gln Val Glu 
    1145                 1150                 1155             


His Leu  Gly Gly Gln Arg Phe  Pro Leu Val Lys Asp  Glu Arg Lys 
    1160                 1165                 1170             


Lys Leu  Thr Ile Arg Glu Asn  Leu His Ser Val Gly  Met Val Lys 
    1175                 1180                 1185             


Leu Leu  Ala His Ala Phe Gly  Ala Val Ala Glu Asp  Val Lys Asp 
    1190                 1195                 1200             


Ile Ser  Thr Leu Asp Leu Asn  Thr Val Lys Trp Val  Lys Lys Asp 
    1205                 1210                 1215             


Ala Thr  Leu 
    1220     


<210>  303
<211>  1221
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  303

Met Met Gln Ile Ile Lys Pro Tyr Gly Arg Ser Val Val Asp Thr Gly 
1               5                   10                  15      


Thr Gly Glu Pro Thr Gln Arg Lys Leu Gln Asp Lys Asn Gln Gln Gln 
            20                  25                  30          


His Asp Ile Ser Gln Phe Val His Glu His Ala Glu Leu Val Val Ala 
        35                  40                  45              


Gln Trp Ile Ser Val Ile Asp Lys Ile Ala Arg Lys Pro His Ala Asn 
    50                  55                  60                  


Gly Lys Asn Ala Gly Lys Cys Gly Leu Pro Thr Ala Gly Gln Tyr Gln 
65                  70                  75                  80  


Leu Arg Asp Ile Leu Gly Thr Ala Ala Trp Val Glu Val Leu Lys His 
                85                  90                  95      


Leu Ser Pro Gly Met Asp Ala Gln Arg Gln Gln Tyr Leu Glu Thr Leu 
            100                 105                 110         


Trp Tyr Ser Lys Ile His Pro Tyr Gly Lys Gln Thr Gln Glu Gln Glu 
        115                 120                 125             


Lys Ala Ile Pro Leu Gln Gly Arg Trp Tyr Gln Arg Phe Val Gly Asp 
    130                 135                 140                 


Val Leu Pro Glu Asn Val Asp Val Ala Leu Ala Lys Gln Val Ala Glu 
145                 150                 155                 160 


Arg Ile His Leu His Leu Tyr Glu Ala Ala Leu Arg Ile Asn Pro Glu 
                165                 170                 175     


Val Ser Ala Arg Arg Lys Gly Ser Ile Gln Ala Gln Ala Glu Thr Ile 
            180                 185                 190         


Thr Asn Asn Thr Leu His Pro Val Val Pro Pro Met Thr Trp Ser Lys 
        195                 200                 205             


Ala Asp Trp Ser Ala Tyr Asn Arg Tyr Asp Val Ala Glu Arg Ile Tyr 
    210                 215                 220                 


Leu Glu Ala Lys Tyr Arg Leu Glu Gln Lys Gln Asp Ala Arg Gln Lys 
225                 230                 235                 240 


Lys Gln Pro Ile Gln Pro Glu Trp Arg Ile Asp Gly Ser Leu Ala Gly 
                245                 250                 255     


Lys Leu Leu Phe Glu His Trp Ala Gln Val Phe Lys Gly Ser Asp Gly 
            260                 265                 270         


Lys Ser Arg Ile Ser Glu Ala Lys Thr His Ala Ala Gly Leu Phe Ala 
        275                 280                 285             


Leu His Met Ala Val Lys Asp Phe Tyr Thr Arg Leu Phe Asp Ser Asn 
    290                 295                 300                 


Arg Lys Glu Glu Thr Leu Val Lys Phe Leu Leu Pro Gln Lys Lys Lys 
305                 310                 315                 320 


Ala Leu Gln Glu Lys Leu Thr Gln Lys Leu Gln Asn Thr Asp Val Ala 
                325                 330                 335     


Ala Arg Ile Arg Leu Gly Lys Ile Gln Tyr Tyr Arg Lys Ala Gln Gly 
            340                 345                 350         


Glu Val Val Pro Leu Ala Asn Ser Arg Phe Trp Gly Ser Asp Gly Gln 
        355                 360                 365             


Ala Glu Ile Lys Arg Ala Glu Ala Phe Val Arg Val Trp Arg His Val 
    370                 375                 380                 


Leu Gly Gln Ala Asn Leu Thr Leu Ala Asn Trp Ala Ser Leu Ala Ser 
385                 390                 395                 400 


Pro Ala Asp Leu Trp Gly Gly Asp Ser Phe Phe Gly His Phe Ser Thr 
                405                 410                 415     


His Ile Asn Gly Lys Leu Phe Ala Thr Asp Ile Gly Leu Asp Ser Arg 
            420                 425                 430         


Arg Thr Val Phe Asp Gln Asn Leu His Leu Leu Phe Gly Asp Ala Ala 
        435                 440                 445             


Gly Leu Phe Gln Ser Asp Asp Glu Thr Arg Lys Ala Ser Ile Leu Leu 
    450                 455                 460                 


Ala His Lys Cys Gly Gly Ala Leu Arg Asn Ala Ala Phe His Phe Lys 
465                 470                 475                 480 


Gly Arg Ala Lys Phe Leu Gln Ala Leu Glu Asn Asp Leu Pro Gln Ala 
                485                 490                 495     


Ala Gln Ser Gly Leu Gln Met Gln Leu Ser Lys Leu Trp Asp Glu Ala 
            500                 505                 510         


Gln Asn Gln Gln Gly Ser Arg Leu Leu Lys Ile Leu Glu Gly Ala His 
        515                 520                 525             


Val Phe His Val Cys Thr Gln Glu Gln Val Gln Gln Leu Val Asn Thr 
    530                 535                 540                 


Leu Gly Asn Val Ser Ala Gly Glu Leu Pro Leu Pro Arg Phe Gly Arg 
545                 550                 555                 560 


Val Ile Glu Arg Asn His His Ala Arg Leu Gly Thr Asn Leu Pro Val 
                565                 570                 575     


Arg Gly Asn Arg Gln Ala Met Glu Gln His Pro Ala Arg Lys Cys Gln 
            580                 585                 590         


Tyr Val Met Leu Lys Leu Leu Tyr Glu Arg Ala Phe Arg Val Trp Leu 
        595                 600                 605             


Glu Asn Thr Thr Asp Glu Val Phe Ser Val Trp Leu Glu Thr Ala Leu 
    610                 615                 620                 


Glu Arg Thr Thr Asn Ala Ala Arg Asn Asn Pro Asn Val Gln Gly Lys 
625                 630                 635                 640 


Ser Gln His Glu Arg Glu Leu Val Met Ala Arg Ala Ala Lys Leu Pro 
                645                 650                 655     


Ile Ser Met Arg Ser Lys Gly Gly Lys Gly Lys Glu Lys Ser Ile Arg 
            660                 665                 670         


Gln Phe Phe Tyr Asp Leu Ser Ala Ala Thr Ala Ser Glu Met Arg Val 
        675                 680                 685             


Gln Arg Gly Tyr Ala Ser Asp Ala Gly Lys Ala Arg Glu Gln Ala Glu 
    690                 695                 700                 


Tyr Ile Asp Glu Leu Leu Arg Asp Val Val Ala Leu Ala Phe Arg Glu 
705                 710                 715                 720 


Phe Ile Arg Ala Asn Gly Phe Asp Trp Leu Leu Asp Ile Asp Pro Gln 
                725                 730                 735     


Gln Glu Leu Arg Glu Thr Arg Cys Cys Leu Met Glu His Ile Arg Phe 
            740                 745                 750         


Pro Ala Ile Ala Pro Arg Ser Asn Ala Trp Gln Pro Val Leu Tyr Phe 
        755                 760                 765             


Leu Leu His Leu Met Pro Val Gly Glu Val Ser Gln Leu Leu His Gln 
    770                 775                 780                 


Leu Ala Lys Trp Glu Ile Leu Ala Lys Pro Glu Gln Ala Arg Thr Asp 
785                 790                 795                 800 


Glu Glu Gly Met Arg Leu His Ala Leu Gln Gln Thr Leu Lys Leu Tyr 
                805                 810                 815     


Leu Asp Met His Asp Ser His Tyr Thr Gly Ala Glu Ser Met Pro Ala 
            820                 825                 830         


Val Glu Arg Ala Val Leu Asp Thr Phe Ala Thr Phe Tyr Glu Thr Arg 
        835                 840                 845             


Asn Gly Leu Asp Lys Val Phe Glu Asp Gln Gly Asn Gly Arg Asp Gly 
    850                 855                 860                 


Ala Arg Tyr Leu Pro Gln Arg Gly Leu Arg Glu Ile Arg Arg Phe Gly 
865                 870                 875                 880 


His Val Pro Val Leu Gln Ala Leu Val Lys Asp Lys Ile Thr Ala Gln 
                885                 890                 895     


Asp Val Thr His Cys Leu Gln Gln Glu Thr Val Pro Ala Asn Gly Lys 
            900                 905                 910         


Leu Ser Pro Val Ala Gln Ala Gln Gln Arg Arg Glu Thr Leu His Gly 
        915                 920                 925             


Glu Trp Val Lys Glu Arg Lys Gln Phe Lys Ala Tyr Arg Asp Tyr Ala 
    930                 935                 940                 


Ala Ala Leu Gln Thr Val Val Val His Arg Gln Leu Ser Asn His Ile 
945                 950                 955                 960 


Arg Leu Val Asp His Val Ala Ala His Arg Ile Val Met Lys Val Leu 
                965                 970                 975     


Ala Arg Leu Ala Asp Phe Ser Gly Leu Phe Glu Arg Asp Leu Thr Phe 
            980                 985                 990         


Val Thr Leu Ala Ala Leu His Glu  His Gln Leu Gln Pro  Glu Asp Phe 
        995                 1000                 1005             


Phe Val  Ile Asp Asn Pro Pro  Arg Tyr Asn Asn Arg  Gly Glu Leu 
    1010                 1015                 1020             


Glu Lys  Asp Gly Leu Thr Leu  Phe Lys Asn Gly Gln  Val Ile Glu 
    1025                 1030                 1035             


Ala Leu  Gly Lys Val Gln Ala  Cys Arg Asp Ala Leu  Lys His Gln 
    1040                 1045                 1050             


Ile Val  Gly Gln Val Asn Leu  Asp Val His Arg Ser  Val Arg Asn 
    1055                 1060                 1065             


Asp Phe  Ala His Phe Asn Met  Leu Tyr Gly Lys Gln  Arg Thr Thr 
    1070                 1075                 1080             


Glu Ser  Ala Thr Asn Arg Val  Ile Lys Cys Pro Ala  Ala Gln Gly 
    1085                 1090                 1095             


Leu Asn  Leu Thr Cys Trp Val  Asn Cys Ala Arg Asn  Leu Met Ser 
    1100                 1105                 1110             


Tyr Asp  Arg Lys Leu Lys Asn  Ala Val Ser Gln Ser  Ile Ile Glu 
    1115                 1120                 1125             


Leu Met  Glu Arg Glu Gly Phe  Ile Leu Thr Trp Glu  Met Asp Thr 
    1130                 1135                 1140             


Asn His  Gln Leu Cys Ser Pro  Lys Leu Gln Ser Arg  Gln Val Glu 
    1145                 1150                 1155             


His Leu  Gly Gly Gln Arg Phe  Pro Leu Val Lys Asp  Glu Arg Lys 
    1160                 1165                 1170             


Lys Leu  Thr Ile Arg Glu Asn  Leu His Ser Val Gly  Met Val Lys 
    1175                 1180                 1185             


Leu Leu  Ala His Ala Phe Gly  Ala Val Ala Glu Asp  Val Lys Asp 
    1190                 1195                 1200             


Ile Ser  Thr Leu Asp Leu Asn  Thr Val Lys Trp Val  Lys Lys Asp 
    1205                 1210                 1215             


Ala Thr  Leu 
    1220     


<210>  304
<211>  1268
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  304

Met Lys Val Ser Lys Val Asn His Arg Arg Ala Ala Val Ala Val Asn 
1               5                   10                  15      


Lys Lys Ser Val Thr Val Asn Gly Ile Leu Tyr Asp Ala Pro Val Lys 
            20                  25                  30          


Lys Asn Val Lys Thr Gly Asn Met Ser Ala Tyr Val Ser Ser Lys Tyr 
        35                  40                  45              


Val Ile Asp Asn Val Val Lys Asn Ser Ser Arg Leu Tyr Ser Pro Phe 
    50                  55                  60                  


Ser Ser Lys Arg Ile Val Ile Asp Arg Glu Lys Ile Arg Ile Ala Asp 
65                  70                  75                  80  


Arg Leu Lys Gln Cys Tyr Val Asn Phe Val Lys Tyr Tyr Leu Ser Asn 
                85                  90                  95      


Gly Ser Leu Asn Glu Gln Gln Met Arg Phe Asn Pro Asn Asn Thr Tyr 
            100                 105                 110         


Met Ala Asp Ser Arg Val His Phe Cys Val Pro Ser Gly Ile Asp Ile 
        115                 120                 125             


Glu Ser Leu Ile Asn Ser Ile Val Asp Ser Ser Leu Arg Lys Ser Leu 
    130                 135                 140                 


Lys Arg Thr Tyr Arg Phe Glu Thr Asn Tyr Gly Glu Lys Asn Thr Phe 
145                 150                 155                 160 


Asn Leu Pro Asp Leu Val Lys Lys Ser Ile Lys Ile Tyr Cys Thr Asp 
                165                 170                 175     


Glu Lys Arg Lys Leu Asn Asp Arg Glu Glu Gln Glu Met Tyr Val Leu 
            180                 185                 190         


Phe Ser Tyr Met Tyr Glu Asp Lys Tyr Lys Asp Arg Gln Lys Val Leu 
        195                 200                 205             


Ile Ala Asn Ser Ile Ser Asn Gln Ala Thr Lys Val Lys Val Cys Asp 
    210                 215                 220                 


Asp Glu Ser Arg Leu Ile Lys Leu Ser Ile Ala Asp Thr Lys Lys Lys 
225                 230                 235                 240 


Pro Leu Trp Asp Phe Ile Val Asp Tyr Ala Asn Ser Asp Lys Asn Gly 
                245                 250                 255     


Gln Tyr Thr Ile Leu Arg Asn Ile Arg Lys Ser Ile Val Leu Phe Val 
            260                 265                 270         


Cys Gly Val Asp Val Tyr Arg Asn Ile Glu Asn Asn Asp Asn Leu Asp 
        275                 280                 285             


Ile Trp Lys Trp Glu Glu Tyr Gly Ile Gln Glu Ser Gln Leu Phe Val 
    290                 295                 300                 


Lys Ile Glu Asn Cys Tyr Thr Thr Lys Gly Glu Asp Ile Ala Leu Asn 
305                 310                 315                 320 


Glu Ile Arg Asn Val Asn Leu Asp His Tyr Met Lys Ala Ile Gly Val 
                325                 330                 335     


Leu Asp Asp Glu Arg Ser Lys Phe Trp Phe Gln His Tyr Glu Asn Thr 
            340                 345                 350         


Ile Glu Ala Leu Phe Leu Lys Lys Ser Lys Arg Lys Ile Glu Arg Ile 
        355                 360                 365             


Lys Thr Ala Tyr Leu Cys Glu Tyr Leu Trp Lys Asn Phe Cys Ser Tyr 
    370                 375                 380                 


Val Ala Leu Lys Tyr Val Asp Leu Gly Lys Gly Val Tyr His Phe Thr 
385                 390                 395                 400 


Met Ser Asp Lys Leu Ser Leu Met Asn Lys Asn Thr Asn Glu Asn Gly 
                405                 410                 415     


Ile Lys Phe Gly Glu Val Asp Ser Arg Phe Asn Lys Gly Ile Ser Ser 
            420                 425                 430         


Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Thr Ile Asp Arg Asn Ile 
        435                 440                 445             


Ser Thr Tyr Thr Thr Phe Ala Thr Asn Ile Phe Ala Lys Ser Val Ile 
    450                 455                 460                 


Lys Asp Ser Tyr Arg Gln Lys Lys Ala Gly Asn Ser Asp Ala Leu Gln 
465                 470                 475                 480 


Tyr Asp Asp Glu Thr Tyr Tyr Asn Arg Lys Ala Met Asn Pro Tyr Ala 
                485                 490                 495     


Leu Lys Arg Val Leu Arg Tyr Trp Gly Gly Gln Ser Arg Trp Lys Ser 
            500                 505                 510         


Glu Leu Glu Glu Leu Asn Val Ala Glu Leu Cys Ile Asp Ile Lys Asn 
        515                 520                 525             


Arg Leu Ser Lys Ile Arg Asn Ser Gly Val His Tyr Thr Ser Thr Leu 
    530                 535                 540                 


Ala Leu Lys Gly Asn Asp Asp Asp Ser Ile Val Gly Met Leu Ile Lys 
545                 550                 555                 560 


Lys Asp Phe Asp Asp Ile Lys Asp Val Tyr Ala Ser Lys Tyr Tyr Ser 
                565                 570                 575     


Asn Asn Val Trp Met Phe Tyr Asn Thr Asp Lys Ile Ser Lys Met Met 
            580                 585                 590         


Glu Tyr Leu Tyr Gln Asp Asp Ser Asn Ile Arg Asp Ala Gln Ile Pro 
        595                 600                 605             


Ala Phe Asn Ser Val Ile Lys Arg Lys Asp Met Ala Glu Val Ile Glu 
    610                 615                 620                 


Lys Ile Ile Lys Lys Asn Ser Tyr Lys Thr Ile Lys Glu Pro Tyr Gln 
625                 630                 635                 640 


Arg Glu Lys Tyr Arg Ser Cys Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
                645                 650                 655     


Tyr Asn Arg Phe Ile Lys Gln Asp Asn Leu Lys Asp Gln Val Ile Gln 
            660                 665                 670         


Ile Ile Asp Ser Asn Thr Glu Leu Ile Gly Asp Asn Ser Arg Ala Val 
        675                 680                 685             


Asp Asn Leu Lys Lys Arg Ile His Asp Val Asp Ser Gln Thr Met Ser 
    690                 695                 700                 


Phe Gly Glu Leu Cys Gln Val Ile Met Thr Asp Tyr Asn Met Gln Asn 
705                 710                 715                 720 


Gln Glu Asn Lys Ser Ile Lys Ser Lys Glu Arg Gln Asp Lys Asp Arg 
                725                 730                 735     


Lys Asn Gly Ile Asp Asn Ser Tyr Lys His Phe Pro Leu Leu Leu His 
            740                 745                 750         


His Leu Ile Lys Val Ser Phe Leu Lys Phe Ile Lys Thr Asp Glu Lys 
        755                 760                 765             


Leu Ala Phe Ile Arg Glu Pro Arg Ile Thr Glu Leu Asp Lys Thr Leu 
    770                 775                 780                 


Glu Gln Phe Glu Ala Gln Ile Gln Thr Val Asp Ile Tyr Asn Ser Leu 
785                 790                 795                 800 


Lys Met Met Val Ala Glu Asn Lys Ser Leu Leu Asp Trp Tyr Thr Leu 
                805                 810                 815     


Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asp Val 
            820                 825                 830         


Lys Asn Tyr Ile Gln Tyr Leu Ser Asn Ile Asp Lys Arg Ala Gly Ser 
        835                 840                 845             


Val Lys Asn Asn Lys Ser Ala Ser Thr Glu Val Lys Ile Arg Gln Tyr 
    850                 855                 860                 


Ser Glu Ile Val Arg Ile Leu Asp Phe Ser Leu Gln Tyr Ile Gly Arg 
865                 870                 875                 880 


Val Ser Asn Asp Val Thr Asp Tyr Phe Val Asp Glu Asp Glu Tyr Ala 
                885                 890                 895     


Ala Phe Leu Ser Lys Tyr Val Glu Phe Ser Gly Asn Asp Ile Val Ser 
            900                 905                 910         


Met Lys Ala Phe Cys Gln Ser Arg Thr Ala Asn Gly Lys His Thr Ile 
        915                 920                 925             


Gly Leu Tyr Cys Asp Gly Ala Asn Pro Ile Met Asn Arg Asn Ile Ala 
    930                 935                 940                 


Tyr Ala Lys Met Tyr Gly Asn Asp Glu Ile Leu Ser Tyr Ile Tyr Asn 
945                 950                 955                 960 


Lys Val Thr Lys Lys Asp Ile Glu Lys Tyr Tyr Val Ser Gln Asp Asn 
                965                 970                 975     


Leu Glu Lys Val Phe Ala Asp Gly Lys Cys Gln Asp Val Gln Gln Gln 
            980                 985                 990         


Asn Ala Leu Cys Asp Phe Gln Lys  Met Lys Asn His Ile  Glu Leu Thr 
        995                 1000                 1005             


Glu Val  Ser Ile Tyr Thr Asp  Ile Leu Asn Asp Phe  Met Ala Gln 
    1010                 1015                 1020             


Phe Ile  Ser Trp Ala Tyr Leu  Arg Glu Arg Asp Leu  Met Tyr Phe 
    1025                 1030                 1035             


Gln Leu  Gly Leu Asn Tyr Ile  Arg Met Phe Tyr Gly  Thr Tyr Glu 
    1040                 1045                 1050             


Leu Glu  Glu Lys Tyr Tyr Lys  Leu His Gly Glu Asn  Ile Asn Ile 
    1055                 1060                 1065             


Glu Lys  Gly Ala Leu Leu Tyr  Gln Ile Val Ala Met  Tyr Ser His 
    1070                 1075                 1080             


Glu Leu  Pro Ile Tyr Lys Val  Asp Glu Ser Gly Ile  Ala Ile Leu 
    1085                 1090                 1095             


Ala Glu  Lys Gln Gly Ser Ser  Gly Ala Ser Ile Lys  Ser Phe Val 
    1100                 1105                 1110             


Thr Glu  Tyr Cys Lys Glu Glu  Met Lys Lys Ala Tyr  Thr Tyr Glu 
    1115                 1120                 1125             


Asn Gly  Leu Glu Leu Phe Glu  Asp Val Asn Gln His  Asp Asp Leu 
    1130                 1135                 1140             


Ser Lys  Leu Arg Asn Asp Phe  Ala His Met Arg Tyr  Met Ser Ala 
    1145                 1150                 1155             


Arg Asp  Lys Ser Ile Met Asp  Ile Val Ser Glu Ile  Tyr Asn Gly 
    1160                 1165                 1170             


Phe Phe  Ile Tyr Asp Thr Lys  Leu Lys Lys Ser Val  Ser Phe Ile 
    1175                 1180                 1185             


Phe Lys  Asn Ile Leu Met Arg  Tyr Ala Val Asp Val  Asn Ile Glu 
    1190                 1195                 1200             


Phe Cys  His Lys Gly Asp Asn  Glu Asp Thr Asn Asn  Leu Ile Arg 
    1205                 1210                 1215             


Ile Lys  Asp Glu Val Gly Leu  Tyr Ser Asp Lys Tyr  Thr Tyr Lys 
    1220                 1225                 1230             


Val Glu  Asp Asn Asp Thr Val  Asp Ile Glu Val Arg  Asn Ser Glu 
    1235                 1240                 1245             


Phe Leu  Glu Gln Leu Lys Lys  Leu Leu Glu Tyr Lys  Lys Glu Ser 
    1250                 1255                 1260             


Glu Gly  Ser Glu Leu 
    1265             


<210>  305
<211>  1105
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  305

Met Arg Val Ser Lys Val Asn Val Lys Val Asp Val Asn Gly Lys Lys 
1               5                   10                  15      


Val Asn Lys Met Val Leu Met His Arg Ser Thr Glu Lys Gly Ala Leu 
            20                  25                  30          


Ile Tyr Thr Asn Glu Gln Asn Val Asp Arg Thr Lys Glu Ile Ile Pro 
        35                  40                  45              


Ser Lys Lys Arg Glu Ser Phe Asp Leu Ser Ile Leu Asn Lys Thr Leu 
    50                  55                  60                  


Ile Arg Tyr Glu Thr Val Lys Lys Gln His Leu Asp Arg Asn Lys Tyr 
65                  70                  75                  80  


Lys Asp Ile Glu Ala Ile Phe Lys Ser Lys Lys Leu Pro Gly Thr Ile 
                85                  90                  95      


Asp Asp Glu Ser Ile Ile Pro Phe Leu Asn His Lys Phe His Phe Met 
            100                 105                 110         


Val Thr Tyr Tyr Lys Lys Gly Asp Lys His Ser Phe Ala Leu Ser Glu 
        115                 120                 125             


Cys Ile Lys Lys Ala Val Ala Thr Lys Asn Ile Asn Glu Leu Gln Pro 
    130                 135                 140                 


Tyr Tyr Asp Trp Ala Glu Trp Tyr Ile Asp Asp Lys Ser Glu Lys Ile 
145                 150                 155                 160 


Lys Lys Ser Ile Val Asn Asn Leu Ile Pro Ile Asp Asn Glu Pro Ser 
                165                 170                 175     


Lys Arg Gln Lys Ala Leu Leu Ala Trp Glu Lys Glu Phe Thr Asp Ser 
            180                 185                 190         


Gly Lys Leu Glu Leu Arg Glu Phe His Asn Leu Phe Asn Thr Asp Ile 
        195                 200                 205             


Leu Ile Ala Asp Leu Cys Arg Val Glu Met Gly Glu Leu Arg Asp Asn 
    210                 215                 220                 


Gly Thr Pro Lys Asp Ser Asn Ala Tyr His Arg Lys Leu Lys Lys Ala 
225                 230                 235                 240 


Leu Gln Asp His Gln Ser Val Val Phe Gly Lys Arg Asp Asn Pro Asn 
                245                 250                 255     


Val Asp Lys Arg Asp Asn Ala Gln Leu Ala Ile Tyr Asn Leu Glu Ile 
            260                 265                 270         


Val Lys Tyr Leu Glu His Tyr Phe Pro Ile Lys Ser Ser Glu Arg Arg 
        275                 280                 285             


Asn Thr Ala Asp Asp Ile Ser Tyr Tyr Leu Lys Thr Asp Thr Leu Lys 
    290                 295                 300                 


Asn Thr Ile Thr Arg Gln Leu Glu Asn Ala Leu Arg Ala Asn Leu Leu 
305                 310                 315                 320 


Arg Asn Gly Lys Tyr Gln His His Gly Leu Asn Ala Asp Thr Thr Ser 
                325                 330                 335     


Asp Ser Leu Thr Asn Leu Lys Arg Asp Glu Ala Phe Val Met Asn Leu 
            340                 345                 350         


Ile Thr Thr Ser Ala Phe Ala Ala Asn Asn Ile Arg Asn Ile Val Asp 
        355                 360                 365             


Ser Glu Gln Ala Glu Asp Ile Leu Val Lys Arg Leu Phe Thr Thr Ser 
    370                 375                 380                 


Leu Gln Lys Asp Lys Val Asn Leu His Thr Tyr Lys Leu Phe Phe Pro 
385                 390                 395                 400 


Glu Val Glu Ala Asp Ile Asn Ala Gln Ser Leu Trp Ala Met Arg Gly 
                405                 410                 415     


Ala Val Gln Gln Ile Arg Asn Asn Val Ala His Tyr Lys Lys Asp Ala 
            420                 425                 430         


Leu Lys Thr Ile Phe Asn Val Thr Asp Phe Glu Phe Pro Leu Gln Gly 
        435                 440                 445             


Asp Asn Pro Lys Tyr Ser Glu Thr Ile Tyr Lys Gln Leu Phe Glu Lys 
    450                 455                 460                 


Glu Leu Glu Lys Leu Pro Glu Ala Phe Ala Leu Gln Leu Lys Ser Gly 
465                 470                 475                 480 


Gly Val Leu Ala Gln Tyr Ser Phe Gln His Leu Lys Gln Leu Leu Glu 
                485                 490                 495     


Lys Val Glu Phe Gln Leu Cys Arg Thr Val Val Pro Phe Ala Pro Gly 
            500                 505                 510         


Phe Lys Lys Val Met Lys Gly Gly Ser Gly Tyr Gln Asn Ser Lys Gln 
        515                 520                 525             


Asp Glu Lys Phe Tyr Asn Leu Glu Leu Asn Ala Phe Arg Ser Lys Asp 
    530                 535                 540                 


Asp Tyr Ser Glu Glu Ala Trp Asn Gly Arg Tyr Phe Leu Leu Lys Thr 
545                 550                 555                 560 


Ile Tyr Asn Tyr Leu Phe Leu Pro Glu Phe Met Asp Asn Ser Ile Gly 
                565                 570                 575     


Phe Ala Asp Thr Val Ala Trp Leu Leu Lys Lys Asn Lys Leu Gln Ala 
            580                 585                 590         


Gln Gly Gly Asn Ala Tyr Ala Phe Ala Asp Val Arg Phe Met Gln Arg 
        595                 600                 605             


Gly Glu Ser Ile Ala Asp Tyr Met Ala Tyr Val Gln Ser Gln Trp Met 
    610                 615                 620                 


His Glu Gln Asn Lys Lys Glu Asp Ser Lys Glu Asp Asp Thr Arg Ile 
625                 630                 635                 640 


Asn Phe Glu Lys Phe Val Leu Gln Leu Phe Ile Lys Gly Phe Asp Thr 
                645                 650                 655     


Phe Leu Gln Ser Ala Glu Tyr Ala Phe Ile Asn Val Pro Gln Pro Gln 
            660                 665                 670         


Ile Asn Leu Ser Asp Ser Asn Gln Leu Gln Ala Asp Lys Met Asn Ala 
        675                 680                 685             


Leu Glu Lys Ala Ile Arg Pro Leu Cys Arg Ile Ser Arg Lys Tyr Ile 
    690                 695                 700                 


Lys Pro Glu Lys Asp Glu Gln Ile Ala Phe Tyr Val Tyr Cys Lys Leu 
705                 710                 715                 720 


Leu Asp Ala Asn His Leu Ser Ala Leu Arg Asn Glu Leu Ile Lys Phe 
                725                 730                 735     


Arg Leu Ser Ser Gly Asn Glu Ser Leu Asn His Leu Pro Glu Ile Ile 
            740                 745                 750         


Glu Leu Cys Leu Ile Gly Val Asp Ala Val Pro Thr Asp Tyr Arg Gln 
        755                 760                 765             


Ile Tyr Ala Thr Arg Glu Gln Cys Leu Asp Arg Leu Lys Pro Phe Val 
    770                 775                 780                 


Ala Asp Gly Ala Asp Tyr Ala His Trp Ser Asp Leu Tyr Val Gln Thr 
785                 790                 795                 800 


Asp Gln Glu Thr Pro Val Ile His Ala Gly Ile Glu Leu Ser Val Lys 
                805                 810                 815     


Tyr Gly Thr Ala Ala Leu Leu Glu Gln Leu Ile Ala Ser Gln Pro Ala 
            820                 825                 830         


Phe Lys Ile Asn Asp Asp Asn Phe Gly Lys Trp Asn Asn Leu Lys Lys 
        835                 840                 845             


Asp Ile Gln Glu Lys Met Ala Lys His Thr Glu Phe His Lys Ala Trp 
    850                 855                 860                 


Val Glu Ala Lys Glu Lys Asp Asp Lys Glu Arg Arg Glu Arg Val Arg 
865                 870                 875                 880 


Ser Arg Ser Asn Phe Ala Gln Gln Phe Ile Arg Lys Asn Glu Glu Asp 
                885                 890                 895     


Tyr Ile Asn Asn Cys Ile Glu Ile Asn Asn Tyr Asn Trp Leu Asp Asn 
            900                 905                 910         


Lys Leu His Phe Glu His Leu Lys Arg Leu His Ser Leu Thr Ile Glu 
        915                 920                 925             


Leu Leu Gly Arg Met Ala Gly Phe Val Ala Leu Trp Glu Arg Asp Phe 
    930                 935                 940                 


Gln Tyr Met Asp Arg Gln Arg Val Lys Leu Gln Gly Gly Ala Leu Leu 
945                 950                 955                 960 


Asn Phe Asp His Gly Val Pro Asn Glu Lys Ala Val Lys Pro His Asp 
                965                 970                 975     


Ala Tyr Phe Lys Arg Val Phe Leu Cys Asp Asp Asp Tyr Arg Gln Ile 
            980                 985                 990         


Arg Asn His Ile Ala His Phe Asn  Tyr Leu Thr Thr Gly  Ala Glu Asp 
        995                 1000                 1005             


His Ser  Leu Ile Asp Met Ile  Asn Trp Leu Arg Lys  Leu Leu Gln 
    1010                 1015                 1020             


Tyr Asp  Arg Lys Leu Lys Asn  Ala Val Ser Asn Ala  Phe Ile Asp 
    1025                 1030                 1035             


Leu Phe  Asp Lys His Gly Met  Val Leu Lys Leu Lys  Phe Asp Asp 
    1040                 1045                 1050             


Gln Lys  His Glu Leu Leu Val  Glu Ser Ile Tyr Pro  Lys Lys Ile 
    1055                 1060                 1065             


Tyr His  Leu Gly Thr Ser Lys  Lys Asp Lys Glu Lys  Ser Leu Thr 
    1070                 1075                 1080             


Thr Asn  Gln Val Gln Thr Ala  Tyr Cys Asn Leu Cys  Lys Ala Leu 
    1085                 1090                 1095             


Leu Glu  Met Lys Lys Glu His  
    1100                 1105 


<210>  306
<211>  1155
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  306

Met Lys Leu Thr Ala Thr Lys Asn Ser Ser Asn Ala Gln Phe Tyr Arg 
1               5                   10                  15      


Asp Lys Thr Lys Gly Gln Leu Ile Ser Thr Lys Val Asn Asn Thr Ser 
            20                  25                  30          


Lys Ile Ile Glu Lys Ser Asp Lys Thr Lys Asp Ile Ile Glu Asn Leu 
        35                  40                  45              


Asp His Lys Arg Ser Leu Lys Gly Arg Ile Leu Ile Asn Pro Asp Ser 
    50                  55                  60                  


Lys Gly Lys Ile Lys Leu Asn Thr Asn Glu Phe Lys Ile Lys Ile His 
65                  70                  75                  80  


Ile Glu Lys Ile Ile Asn Thr Leu Ile Tyr Asn Asn His Met Ser Glu 
                85                  90                  95      


Leu Tyr Asp Glu Lys Pro Thr Leu Ser Asp Asp Glu Lys Lys Asp Glu 
            100                 105                 110         


Asn Leu Lys Lys Ile Ile Asn Asn Thr Leu Ser Val Tyr Gly Lys Lys 
        115                 120                 125             


Ile Lys Tyr Asn Ser Asn Ser Lys Asn Leu Glu Glu Ile Leu Ile Cys 
    130                 135                 140                 


Tyr Phe Lys Asn Glu Asp Ile Thr Ser Glu Phe Glu Asn Ile Arg Asn 
145                 150                 155                 160 


Tyr Phe Gln Thr Val Ile Thr His Lys Lys Glu Lys Leu Val Lys Ser 
                165                 170                 175     


Ile Lys Asn Asn Lys Ile Pro Phe Asp Leu Asp Asn Asn Ser Leu Gln 
            180                 185                 190         


Pro Asn Ser Glu Lys Met Lys Trp Leu Phe Ser Phe Ile Lys Asn Gly 
        195                 200                 205             


Val Ile Thr Ala Glu Ile Lys Glu Asn Thr Phe Leu Lys Asp Ile Tyr 
    210                 215                 220                 


Lys Tyr Glu Asn Leu Glu Lys Val Leu Asn Glu Glu Leu Asn Asn Gln 
225                 230                 235                 240 


Ile Lys Asn Asn Lys Pro Val Met Thr Lys Lys Leu Tyr Gln Met Val 
                245                 250                 255     


Leu Asp Tyr Asn Gln Asp Ile Tyr Ile Asn His Ile Asn Gly Glu Asn 
            260                 265                 270         


Glu Gln Asp Ser Phe Tyr Leu Asn Glu Ile Arg Glu His Phe Arg Arg 
        275                 280                 285             


Tyr Leu Val Ile Ser Lys Lys Ser Asn Thr Lys Asn Gln Asn Gly Tyr 
    290                 295                 300                 


Asn Glu Lys Ile Lys Pro Glu Lys Ile Arg His His Ile Ala Tyr Glu 
305                 310                 315                 320 


Phe Val Thr Glu Asn Ile Gln Lys His Ile Ile Asn Gln Leu Val Ala 
                325                 330                 335     


Gly Leu Ile Gln Tyr Gly Lys Leu His His Tyr Phe Tyr Asp Lys Thr 
            340                 345                 350         


Thr Ser Ser Trp Gln Lys Glu Lys Leu Asn Ser Asp Gly Leu Ser Glu 
        355                 360                 365             


Ile Gln Val Glu Glu Ala Phe Lys Lys Gln Ile Leu Thr Ser Ile Ser 
    370                 375                 380                 


Ser Gly Ile Ala Lys Leu Asn Tyr Phe Tyr Asn His Gly Ser Gln Asn 
385                 390                 395                 400 


Glu Ser Lys Ile Asn Thr Asp Lys Asn Val Asp Val Leu Asp Ser Asp 
                405                 410                 415     


Lys Val Gln Leu Gln Leu Thr Ser Asp Thr Asp Asp Thr Glu Phe Lys 
            420                 425                 430         


Ile Ser Thr Cys Phe Pro Ile Asp Leu Ala Lys Asp Tyr Leu Asn Leu 
        435                 440                 445             


Glu Lys Phe Ile Asp Thr Ile Arg Gly Asn Ile Asp Lys Ile Arg Asn 
    450                 455                 460                 


Asn Thr Phe His Phe Lys Lys Asn Glu Leu Lys Asn Leu Phe Asn Asp 
465                 470                 475                 480 


Gly Ser Tyr Asn Asn Thr Asn Ile Thr Phe Ile Lys Glu Leu Phe Gln 
                485                 490                 495     


Arg Asp Leu Asn Ser Val Gln Glu Ser Phe Lys Glu Gln Ile Arg Ser 
            500                 505                 510         


Ser Gly Ile Thr Glu Tyr Cys Ser Phe Glu Leu Leu Lys Asn Ile Phe 
        515                 520                 525             


Gln Glu Asn Ser Phe Asp Phe Gln Leu Tyr Ser Pro Gln Tyr Pro Met 
    530                 535                 540                 


Ser Pro Ser Phe Lys Asn Ile Tyr Lys Arg Gly Cys Asn Leu Ser Asn 
545                 550                 555                 560 


Ala Thr Val Lys Asp Glu Lys Ile Lys Trp Ile Lys Pro Leu Asp Ala 
                565                 570                 575     


Asp Ala Glu Asn Asp Gly Gln Leu Ala Tyr Lys Asn Leu Leu Gln Leu 
            580                 585                 590         


Ile Tyr Tyr His Cys Phe Leu Pro Tyr Val Phe Lys Asn Glu Ser Tyr 
        595                 600                 605             


Leu Ile Lys Tyr Ile Lys Thr Thr Lys Asp Trp Asn Gln Gln Lys Ala 
    610                 615                 620                 


Lys Asn Asp Arg Gln Asn Arg His Gln Tyr Arg Tyr Glu Asn Met Pro 
625                 630                 635                 640 


Phe Tyr Asn Asn Asn Lys Phe Thr Ser Leu Asn Asp Tyr Phe Gln Asn 
                645                 650                 655     


Leu Gln Arg Leu Gln Ser Ile Tyr Glu Asn Asp Glu Asp Ala Lys His 
            660                 665                 670         


Glu Asn Tyr Tyr Leu Asp Phe Ile Gln Asp Ile Phe Leu Leu Ala Phe 
        675                 680                 685             


Asp Asn Tyr Leu Glu Asp Lys Leu Lys Asn Tyr Lys Tyr Lys Leu Ile 
    690                 695                 700                 


Phe Ser Glu Lys Leu Val Asp Ser Ser Leu Glu Ser Leu Glu Thr Leu 
705                 710                 715                 720 


Glu Lys Leu Phe Glu Lys Thr Asn Thr Ile Leu Lys Met Asn Val Asn 
                725                 730                 735     


Ser Ser Phe Glu Asn Asn Leu Asn Phe Tyr Ala Phe Leu Arg Val Leu 
            740                 745                 750         


Glu Lys Arg Glu Leu Asn Asn Leu Leu His Gln Ile Ile Lys Tyr Arg 
        755                 760                 765             


Thr Ser Lys Asn Glu Glu Ser Leu Arg Glu Ile Glu Glu Leu Ile Thr 
    770                 775                 780                 


Leu Val Gln Tyr Thr Ile Pro Leu Gln Thr Ala Asp Glu His Phe Gln 
785                 790                 795                 800 


Asn Glu Leu Lys Asn His Phe Lys Tyr Phe Phe Glu Asp Glu Asn Phe 
                805                 810                 815     


Asn Asn Asn Cys Glu Leu Tyr Tyr Gln Ser Asp Lys Lys Thr Pro Ile 
            820                 825                 830         


Ala His Arg Ser Met Ser Leu Met Gly Arg Ser Gly Ile Met Ala Leu 
        835                 840                 845             


Phe Lys Val Met Phe Ser Thr Asp Tyr Lys Ile Lys Lys Glu Asp Phe 
    850                 855                 860                 


Asp Asn Tyr Leu Lys Met Ile Asp Ser Ala Glu Leu Ile Asn Asp Glu 
865                 870                 875                 880 


Thr Pro Lys Ser Ile Gln Asp Lys Gln Lys Lys Val His Asp Leu His 
                885                 890                 895     


Arg Glu Leu Val Ser Lys Lys Ile Ile Asn Ile Lys Asn Lys Asp Glu 
            900                 905                 910         


Ile Asp Lys Leu Glu Glu Tyr Glu Lys Leu Val Lys Glu Ile Lys Glu 
        915                 920                 925             


Tyr Glu His Leu Arg His Lys Leu Thr Phe Glu Thr Leu Tyr Lys Val 
    930                 935                 940                 


Tyr Lys Ile Tyr Ile Asp Ile Ile Ser Arg Leu Ala Ser Phe Ala Glu 
945                 950                 955                 960 


Asp Trp Glu Arg Asp Met Tyr Phe Met Met Ile Ala Leu Lys Glu Leu 
                965                 970                 975     


Asn His Ile Asn Gln Asn Val Asp Ile Asp Glu Ile Phe Asn Tyr Asn 
            980                 985                 990         


Pro Val Asp Lys Lys Thr Val Ser  Gln Lys Phe Lys Glu  Asn Leu Gly 
        995                 1000                 1005             


Lys Thr  Ile Lys Asn Lys Asn  Leu Val Leu Phe Leu  Phe Trp Met 
    1010                 1015                 1020             


Asp Asn  Ser Lys Asn Asn Ser  Asn Asn Phe Leu Val  Arg Asn Ser 
    1025                 1030                 1035             


Ile Ala  His Leu Asn His Met  Asn Gln Tyr Lys Leu  Asn Asp Ala 
    1040                 1045                 1050             


His Ser  Gln Lys Asn Ile Ile  Glu Leu Ile Asn Arg  Ile Arg Ile 
    1055                 1060                 1065             


Leu Leu  Ala Tyr Asp Leu Lys  Arg Gln Asn Ser Val  Thr Lys Ser 
    1070                 1075                 1080             


Ile Ile  Glu Ile Leu Glu Lys  Gln His Asp Ile Lys  Ile Lys Phe 
    1085                 1090                 1095             


Thr Gly  Lys Lys Asp Asn Asn  Asn Tyr Asn Phe Glu  Leu Asn Ser 
    1100                 1105                 1110             


Val Glu  Ser Asp Asn Ile Ile  His Leu Lys Lys Ile  Gln Lys Asp 
    1115                 1120                 1125             


Lys Asp  Asn Lys Ile Lys Ile  Pro Thr His Asp Glu  Leu Thr Ile 
    1130                 1135                 1140             


Lys Leu  Val Glu Lys Leu Leu  Thr Phe Lys Phe Gln  
    1145                 1150                 1155 


<210>  307
<211>  1221
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  307

Met Met Gln Ile Ile Lys Pro Tyr Gly Arg Ser Val Val Asp Thr Gly 
1               5                   10                  15      


Thr Gly Glu Pro Thr Gln Arg Lys Leu Gln Asp Lys Asn Gln Gln Gln 
            20                  25                  30          


His Asp Ile Ser Gln Phe Val His Glu His Ala Glu Leu Val Val Ala 
        35                  40                  45              


Gln Trp Ile Ser Val Ile Asp Lys Ile Ala Arg Lys Pro His Ala Asn 
    50                  55                  60                  


Gly Lys Asn Ala Gly Lys Cys Gly Leu Pro Thr Ala Gly Gln Tyr Gln 
65                  70                  75                  80  


Leu Arg Asp Ile Leu Gly Thr Ala Ala Trp Val Glu Val Leu Lys His 
                85                  90                  95      


Leu Ser Pro Gly Met Asp Ala Gln Arg Gln Gln Tyr Leu Glu Thr Leu 
            100                 105                 110         


Trp Tyr Ser Lys Ile His Pro Tyr Gly Lys Gln Thr Gln Glu Gln Glu 
        115                 120                 125             


Lys Ala Ile Pro Leu Gln Gly Arg Trp Tyr Gln Arg Phe Val Gly Asp 
    130                 135                 140                 


Val Leu Pro Glu Asn Val Asp Val Ala Leu Ala Lys Gln Val Ala Glu 
145                 150                 155                 160 


Arg Ile His Leu His Leu Tyr Glu Ala Ala Leu Arg Ile Asn Pro Glu 
                165                 170                 175     


Val Ser Ala Arg Arg Lys Gly Ser Ile Gln Ala Gln Ala Glu Thr Ile 
            180                 185                 190         


Thr Asn Asn Thr Leu His Pro Val Val Pro Pro Met Thr Trp Ser Lys 
        195                 200                 205             


Ala Asp Trp Ser Ala Tyr Asn Arg Tyr Asp Val Ala Glu Arg Ile Tyr 
    210                 215                 220                 


Leu Glu Ala Lys Tyr Arg Leu Glu Gln Lys Gln Asp Ala Arg Gln Lys 
225                 230                 235                 240 


Lys Gln Pro Ile Gln Pro Glu Trp Arg Ile Asp Gly Ser Leu Ala Gly 
                245                 250                 255     


Lys Leu Leu Phe Glu His Trp Ala Gln Val Phe Lys Gly Ser Asp Gly 
            260                 265                 270         


Lys Ser Arg Ile Ser Glu Ala Lys Thr His Ala Ala Gly Leu Phe Ala 
        275                 280                 285             


Leu His Met Ala Val Lys Asp Phe Tyr Thr Arg Leu Phe Asp Ser Asn 
    290                 295                 300                 


Arg Lys Glu Glu Thr Leu Val Lys Phe Leu Leu Pro Gln Lys Lys Lys 
305                 310                 315                 320 


Ala Leu Gln Glu Lys Leu Thr Gln Lys Leu Gln Asn Thr Asp Val Ala 
                325                 330                 335     


Ala Arg Ile Arg Leu Gly Lys Ile Gln Tyr Tyr Arg Lys Ala Gln Gly 
            340                 345                 350         


Glu Val Val Pro Leu Ala Asn Ser Arg Phe Trp Gly Ser Asp Gly Gln 
        355                 360                 365             


Ala Glu Ile Lys Arg Ala Glu Ala Phe Val Arg Val Trp Arg His Val 
    370                 375                 380                 


Leu Gly Gln Ala Asn Leu Thr Leu Ala Asn Trp Ala Ser Leu Ala Ser 
385                 390                 395                 400 


Pro Ala Asp Leu Trp Gly Gly Asp Ser Phe Phe Gly His Phe Ser Thr 
                405                 410                 415     


His Ile Asn Gly Lys Leu Phe Ala Thr Asp Ile Gly Leu Asp Ser Arg 
            420                 425                 430         


Arg Thr Val Phe Asp Gln Asn Leu His Leu Leu Phe Gly Asp Ala Ala 
        435                 440                 445             


Gly Leu Phe Gln Ser Asp Asp Glu Thr Arg Lys Ala Ser Ile Leu Leu 
    450                 455                 460                 


Ala His Lys Cys Gly Gly Ala Leu Arg Asn Ala Ala Phe His Phe Lys 
465                 470                 475                 480 


Gly Arg Ala Lys Phe Leu Gln Ala Leu Glu Asn Asp Leu Pro Gln Ala 
                485                 490                 495     


Ala Gln Ser Gly Leu Gln Met Gln Leu Ser Lys Leu Trp Asp Glu Ala 
            500                 505                 510         


Gln Asn Gln Gln Gly Ser Arg Leu Leu Lys Ile Leu Glu Gly Ala His 
        515                 520                 525             


Val Phe His Val Cys Thr Gln Glu Gln Val Gln Gln Leu Val Asn Thr 
    530                 535                 540                 


Leu Gly Asn Val Ser Ala Gly Glu Leu Pro Leu Pro Arg Phe Gly Arg 
545                 550                 555                 560 


Val Ile Glu Arg Asn His His Ala Arg Leu Gly Thr Asn Leu Pro Val 
                565                 570                 575     


Arg Gly Asn Arg Gln Ala Met Glu Gln His Pro Ala Arg Lys Cys Gln 
            580                 585                 590         


Tyr Val Met Leu Lys Leu Leu Tyr Glu Arg Ala Phe Arg Val Trp Leu 
        595                 600                 605             


Glu Asn Thr Thr Asp Glu Val Phe Ser Val Trp Leu Glu Thr Ala Leu 
    610                 615                 620                 


Glu Arg Thr Thr Asn Ala Ala Arg Asn Asn Pro Asn Val Gln Gly Lys 
625                 630                 635                 640 


Ser Gln His Glu Arg Glu Leu Val Met Ala Arg Ala Ala Lys Leu Pro 
                645                 650                 655     


Ile Ser Met Arg Ser Lys Gly Gly Lys Gly Lys Glu Lys Ser Ile Arg 
            660                 665                 670         


Gln Phe Phe Tyr Asp Leu Ser Ala Ala Thr Ala Ser Glu Met Arg Val 
        675                 680                 685             


Gln Arg Gly Tyr Ala Ser Asp Ala Gly Lys Ala Arg Glu Gln Ala Glu 
    690                 695                 700                 


Tyr Ile Asp Glu Leu Leu Arg Asp Val Val Ala Leu Ala Phe Arg Glu 
705                 710                 715                 720 


Phe Ile Arg Ala Asn Gly Phe Asp Trp Leu Leu Asp Ile Asp Pro Gln 
                725                 730                 735     


Gln Glu Leu Arg Glu Thr Arg Cys Cys Leu Met Glu His Ile Arg Phe 
            740                 745                 750         


Pro Ala Ile Ala Pro Arg Ser Asn Ala Trp Gln Pro Val Leu Tyr Phe 
        755                 760                 765             


Leu Leu His Leu Met Pro Val Gly Glu Val Ser Gln Leu Leu His Gln 
    770                 775                 780                 


Leu Ala Lys Trp Glu Ile Leu Ala Lys Pro Glu Gln Ala Arg Thr Asp 
785                 790                 795                 800 


Glu Glu Gly Met Arg Leu His Ala Leu Gln Gln Thr Leu Lys Leu Tyr 
                805                 810                 815     


Leu Asp Met His Asp Ser His Tyr Thr Gly Ala Glu Ser Met Pro Ala 
            820                 825                 830         


Val Glu Arg Ala Val Leu Asp Thr Phe Ala Thr Phe Tyr Glu Thr Arg 
        835                 840                 845             


Asn Gly Leu Asp Lys Val Phe Glu Asp Gln Gly Asn Gly Arg Asp Gly 
    850                 855                 860                 


Ala Arg Tyr Leu Pro Gln Arg Gly Leu Arg Glu Ile Arg Arg Phe Gly 
865                 870                 875                 880 


His Val Pro Val Leu Gln Ala Leu Val Lys Asp Lys Ile Thr Ala Gln 
                885                 890                 895     


Asp Val Thr His Cys Leu Gln Gln Glu Thr Val Pro Ala Asn Gly Lys 
            900                 905                 910         


Leu Ser Pro Val Ala Gln Ala Gln Gln Arg Arg Glu Thr Leu His Gly 
        915                 920                 925             


Glu Trp Val Lys Glu Arg Lys Gln Phe Lys Ala Tyr Arg Asp Tyr Ala 
    930                 935                 940                 


Ala Ala Leu Gln Thr Val Val Val His Arg Gln Leu Ser Asn His Ile 
945                 950                 955                 960 


Arg Leu Val Asp His Val Ala Ala His Arg Ile Val Met Lys Val Leu 
                965                 970                 975     


Ala Arg Leu Ala Asp Phe Ser Gly Leu Phe Glu Arg Asp Leu Thr Phe 
            980                 985                 990         


Val Thr Leu Ala Ala Leu His Glu  His Gln Leu Gln Pro  Glu Asp Phe 
        995                 1000                 1005             


Phe Val  Ile Asp Asn Pro Pro  Arg Tyr Asn Asn Arg  Gly Glu Leu 
    1010                 1015                 1020             


Glu Lys  Asp Gly Leu Thr Leu  Phe Lys Asn Gly Gln  Val Ile Glu 
    1025                 1030                 1035             


Ala Leu  Gly Lys Val Gln Ala  Cys Arg Asp Ala Leu  Lys His Gln 
    1040                 1045                 1050             


Ile Val  Gly Gln Val Asn Leu  Asp Val His Arg Ser  Val Arg Asn 
    1055                 1060                 1065             


Asp Phe  Ala His Phe Asn Met  Leu Tyr Gly Lys Gln  Arg Thr Thr 
    1070                 1075                 1080             


Glu Ser  Ala Thr Asn Arg Val  Ile Lys Cys Pro Ala  Ala Gln Gly 
    1085                 1090                 1095             


Leu Asn  Leu Thr Cys Trp Val  Asn Cys Ala Arg Asn  Leu Met Ser 
    1100                 1105                 1110             


Tyr Asp  Arg Lys Leu Lys Asn  Ala Val Ser Gln Ser  Ile Ile Glu 
    1115                 1120                 1125             


Leu Met  Glu Arg Glu Gly Phe  Ile Leu Thr Trp Glu  Met Asp Thr 
    1130                 1135                 1140             


Asn His  Gln Leu Cys Ser Pro  Lys Leu Gln Ser Arg  Gln Val Glu 
    1145                 1150                 1155             


His Leu  Gly Gly Gln Arg Phe  Pro Leu Val Lys Asp  Glu Arg Lys 
    1160                 1165                 1170             


Lys Leu  Thr Ile Arg Glu Asn  Leu His Ser Val Gly  Met Val Lys 
    1175                 1180                 1185             


Leu Leu  Ala His Ala Phe Gly  Ala Val Ala Glu Asp  Val Lys Asp 
    1190                 1195                 1200             


Ile Ser  Thr Leu Asp Leu Asn  Thr Val Lys Trp Val  Lys Lys Asp 
    1205                 1210                 1215             


Ala Thr  Leu 
    1220     


<210>  308
<211>  1221
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  308

Met Met Gln Ile Ile Lys Pro Tyr Gly Arg Ser Val Val Asp Thr Gly 
1               5                   10                  15      


Thr Gly Glu Pro Thr Gln Arg Lys Leu Gln Asp Lys Asn Gln Gln Gln 
            20                  25                  30          


His Asp Ile Ser Gln Phe Val His Glu His Ala Glu Leu Val Val Ala 
        35                  40                  45              


Gln Trp Ile Ser Val Ile Asp Lys Ile Ala Arg Lys Pro His Ala Asn 
    50                  55                  60                  


Gly Lys Asn Ala Gly Lys Cys Gly Leu Pro Thr Ala Gly Gln Tyr Gln 
65                  70                  75                  80  


Leu Arg Asp Ile Leu Gly Thr Ala Ala Trp Val Glu Val Leu Lys His 
                85                  90                  95      


Leu Ser Pro Gly Met Asp Ala Gln Arg Gln Gln Tyr Leu Glu Thr Leu 
            100                 105                 110         


Trp Tyr Ser Lys Ile His Pro Tyr Gly Lys Gln Thr Gln Glu Gln Glu 
        115                 120                 125             


Lys Ala Ile Pro Leu Gln Gly Arg Trp Tyr Gln Arg Phe Val Gly Asp 
    130                 135                 140                 


Val Leu Pro Glu Asn Val Asp Val Ala Leu Ala Lys Gln Val Ala Glu 
145                 150                 155                 160 


Arg Ile His Leu His Leu Tyr Glu Ala Ala Leu Arg Ile Asn Pro Glu 
                165                 170                 175     


Val Ser Ala Arg Arg Lys Gly Ser Ile Gln Ala Gln Ala Glu Thr Ile 
            180                 185                 190         


Thr Asn Asn Thr Leu His Pro Val Val Pro Pro Met Thr Trp Ser Lys 
        195                 200                 205             


Ala Asp Trp Ser Ala Tyr Asn Arg Tyr Asp Val Ala Glu Arg Ile Tyr 
    210                 215                 220                 


Leu Glu Ala Lys Tyr Arg Leu Glu Gln Lys Gln Asp Ala Arg Gln Lys 
225                 230                 235                 240 


Lys Gln Pro Ile Gln Pro Glu Trp Arg Ile Asp Gly Ser Leu Ala Gly 
                245                 250                 255     


Lys Leu Leu Phe Glu His Trp Ala Gln Val Phe Lys Gly Ser Asp Gly 
            260                 265                 270         


Lys Ser Arg Ile Ser Glu Ala Lys Thr His Ala Ala Gly Leu Phe Ala 
        275                 280                 285             


Leu His Met Ala Val Lys Asp Phe Tyr Thr Arg Leu Phe Asp Ser Asn 
    290                 295                 300                 


Arg Lys Glu Glu Thr Leu Val Lys Phe Leu Leu Pro Gln Lys Lys Lys 
305                 310                 315                 320 


Ala Leu Gln Glu Lys Leu Thr Gln Lys Leu Gln Asn Thr Asp Val Ala 
                325                 330                 335     


Ala Arg Ile Arg Leu Gly Lys Ile Gln Tyr Tyr Arg Lys Ala Gln Gly 
            340                 345                 350         


Glu Val Val Pro Leu Ala Asn Ser Arg Phe Trp Gly Ser Asp Gly Gln 
        355                 360                 365             


Ala Glu Ile Lys Arg Ala Glu Ala Phe Val Arg Val Trp Arg His Val 
    370                 375                 380                 


Leu Gly Gln Ala Asn Leu Thr Leu Ala Asn Trp Ala Ser Leu Ala Ser 
385                 390                 395                 400 


Pro Ala Asp Leu Trp Gly Gly Asp Ser Phe Phe Gly His Phe Ser Thr 
                405                 410                 415     


His Ile Asn Gly Lys Leu Phe Ala Thr Asp Ile Gly Leu Asp Ser Arg 
            420                 425                 430         


Arg Thr Val Phe Asp Gln Asn Leu His Leu Leu Phe Gly Asp Ala Ala 
        435                 440                 445             


Gly Leu Phe Gln Ser Asp Asp Glu Thr Arg Lys Ala Ser Ile Leu Leu 
    450                 455                 460                 


Ala His Lys Cys Gly Gly Ala Leu Arg Asn Ala Ala Phe His Phe Lys 
465                 470                 475                 480 


Gly Arg Ala Lys Phe Leu Gln Ala Leu Glu Asn Asp Leu Pro Gln Ala 
                485                 490                 495     


Ala Gln Ser Gly Leu Gln Met Gln Leu Ser Lys Leu Trp Asp Glu Ala 
            500                 505                 510         


Gln Asn Gln Gln Gly Ser Arg Leu Leu Lys Ile Leu Glu Gly Ala His 
        515                 520                 525             


Val Phe His Val Cys Thr Gln Glu Gln Val Gln Gln Leu Val Asn Thr 
    530                 535                 540                 


Leu Gly Asn Val Ser Ala Gly Glu Leu Pro Leu Pro Arg Phe Gly Arg 
545                 550                 555                 560 


Val Ile Glu Arg Asn His His Ala Arg Leu Gly Thr Asn Leu Pro Val 
                565                 570                 575     


Arg Gly Asn Arg Gln Ala Met Glu Gln His Pro Ala Arg Lys Cys Gln 
            580                 585                 590         


Tyr Val Met Leu Lys Leu Leu Tyr Glu Arg Ala Phe Arg Val Trp Leu 
        595                 600                 605             


Glu Asn Thr Thr Asp Glu Val Phe Ser Val Trp Leu Glu Thr Ala Leu 
    610                 615                 620                 


Glu Arg Thr Thr Asn Ala Ala Arg Asn Asn Pro Asn Val Gln Gly Lys 
625                 630                 635                 640 


Ser Gln His Glu Arg Glu Leu Val Met Ala Arg Ala Ala Lys Leu Pro 
                645                 650                 655     


Ile Ser Met Arg Ser Lys Gly Gly Lys Gly Lys Glu Lys Ser Ile Arg 
            660                 665                 670         


Gln Phe Phe Tyr Asp Leu Ser Ala Ala Thr Ala Ser Glu Met Arg Val 
        675                 680                 685             


Gln Arg Gly Tyr Ala Ser Asp Ala Gly Lys Ala Arg Glu Gln Ala Glu 
    690                 695                 700                 


Tyr Ile Asp Glu Leu Leu Arg Asp Val Val Ala Leu Ala Phe Arg Glu 
705                 710                 715                 720 


Phe Ile Arg Ala Asn Gly Phe Asp Trp Leu Leu Asp Ile Asp Pro Gln 
                725                 730                 735     


Gln Glu Leu Arg Glu Thr Arg Cys Cys Leu Met Glu His Ile Arg Phe 
            740                 745                 750         


Pro Ala Ile Ala Pro Arg Ser Asn Ala Trp Gln Pro Val Leu Tyr Phe 
        755                 760                 765             


Leu Leu His Leu Met Pro Val Gly Glu Val Ser Gln Leu Leu His Gln 
    770                 775                 780                 


Leu Ala Lys Trp Glu Ile Leu Ala Lys Pro Glu Gln Ala Arg Thr Asp 
785                 790                 795                 800 


Glu Glu Gly Met Arg Leu His Ala Leu Gln Gln Thr Leu Lys Leu Tyr 
                805                 810                 815     


Leu Asp Met His Asp Ser His Tyr Thr Gly Ala Glu Ser Met Pro Ala 
            820                 825                 830         


Val Glu Arg Ala Val Leu Asp Thr Phe Ala Thr Phe Tyr Glu Thr Arg 
        835                 840                 845             


Asn Gly Leu Asp Lys Val Phe Glu Asp Gln Gly Asn Gly Arg Asp Gly 
    850                 855                 860                 


Ala Arg Tyr Leu Pro Gln Arg Gly Leu Arg Glu Ile Arg Arg Phe Gly 
865                 870                 875                 880 


His Val Pro Val Leu Gln Ala Leu Val Lys Asp Lys Ile Thr Ala Gln 
                885                 890                 895     


Asp Val Thr His Cys Leu Gln Gln Glu Thr Val Pro Ala Asn Gly Lys 
            900                 905                 910         


Leu Ser Pro Val Ala Gln Ala Gln Gln Arg Arg Glu Thr Leu His Gly 
        915                 920                 925             


Glu Trp Val Lys Glu Arg Lys Gln Phe Lys Ala Tyr Arg Asp Tyr Ala 
    930                 935                 940                 


Ala Ala Leu Gln Thr Val Val Val His Arg Gln Leu Ser Asn His Ile 
945                 950                 955                 960 


Arg Leu Val Asp His Val Ala Ala His Arg Ile Val Met Lys Val Leu 
                965                 970                 975     


Ala Arg Leu Ala Asp Phe Ser Gly Leu Phe Glu Arg Asp Leu Thr Phe 
            980                 985                 990         


Val Thr Leu Ala Ala Leu His Glu  His Gln Leu Gln Pro  Glu Asp Phe 
        995                 1000                 1005             


Phe Val  Ile Asp Asn Pro Pro  Arg Tyr Asn Asn Arg  Gly Glu Leu 
    1010                 1015                 1020             


Glu Lys  Asp Gly Leu Thr Leu  Phe Lys Asn Gly Gln  Val Ile Glu 
    1025                 1030                 1035             


Ala Leu  Gly Lys Val Gln Ala  Cys Arg Asp Ala Leu  Lys His Gln 
    1040                 1045                 1050             


Ile Val  Gly Gln Val Asn Leu  Asp Val His Arg Ser  Val Arg Asn 
    1055                 1060                 1065             


Asp Phe  Ala His Phe Asn Met  Leu Tyr Gly Lys Gln  Arg Thr Thr 
    1070                 1075                 1080             


Glu Ser  Ala Thr Asn Arg Val  Ile Lys Cys Pro Ala  Ala Gln Gly 
    1085                 1090                 1095             


Leu Asn  Leu Thr Cys Trp Val  Asn Cys Ala Arg Asn  Leu Met Ser 
    1100                 1105                 1110             


Tyr Asp  Arg Lys Leu Lys Asn  Ala Val Ser Gln Ser  Ile Ile Glu 
    1115                 1120                 1125             


Leu Met  Glu Arg Glu Gly Phe  Ile Leu Thr Trp Glu  Met Asp Thr 
    1130                 1135                 1140             


Asn His  Gln Leu Cys Ser Pro  Lys Leu Gln Ser Arg  Gln Val Glu 
    1145                 1150                 1155             


His Leu  Gly Gly Gln Arg Phe  Pro Leu Val Lys Asp  Glu Arg Lys 
    1160                 1165                 1170             


Lys Leu  Thr Ile Arg Glu Asn  Leu His Ser Val Gly  Met Val Lys 
    1175                 1180                 1185             


Leu Leu  Ala His Ala Phe Gly  Ala Val Ala Glu Asp  Val Lys Asp 
    1190                 1195                 1200             


Ile Ser  Thr Leu Asp Leu Asn  Thr Val Lys Trp Val  Lys Lys Asp 
    1205                 1210                 1215             


Ala Thr  Leu 
    1220     


<210>  309
<211>  1330
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  309

Met Lys Arg Glu Lys Asn Ile Thr Ile Met Lys Ile Ser Lys Val Asn 
1               5                   10                  15      


His Arg Arg Thr Ala Val Ala Leu Asn Gly Asp Lys Ser Glu Leu Gly 
            20                  25                  30          


Gly Ile Leu Tyr Glu Ala Pro Val Gln Lys Asp Lys Asn Gly Asn Tyr 
        35                  40                  45              


Asn Asp Val Ile Ala Glu Thr Gly Lys Val Val Asn Glu Ala Leu Asp 
    50                  55                  60                  


Lys Lys Ser Arg Leu Tyr Thr Pro Phe Asn Asn Gln Lys Val Ile Ile 
65                  70                  75                  80  


Asp Lys Asn Leu Gln Arg Tyr Ala Asn Asn Leu Lys Arg Cys Tyr Ile 
                85                  90                  95      


Asn Phe Val Lys Gln Tyr Val Asn Asn Lys Ser Phe Asn Tyr Lys Ala 
            100                 105                 110         


Met Gln Phe Ile Pro Asp Ile Gln Asn Pro Lys Thr Asn Asp Ala Val 
        115                 120                 125             


Asn Tyr Arg Thr Asp Arg Asp Asn Val Tyr Asn Lys Asn Lys Tyr Tyr 
    130                 135                 140                 


Asp Lys Gln Thr Lys Ser Lys Ser Lys Lys Phe Ile Tyr Glu Lys Ile 
145                 150                 155                 160 


Val Ile Pro Gln Asn Glu Gln Asn Ile Val Ile Ser Ala Leu Val Asn 
                165                 170                 175     


Cys Ser Leu Arg Lys Ser Leu Arg Lys Asp Val Ser Tyr Lys Thr Lys 
            180                 185                 190         


Ser Gly Glu Ile Lys Thr Tyr Asn Leu Pro Glu Leu Val Lys Lys Ser 
        195                 200                 205             


Met Arg Phe Tyr Cys Leu Glu Gly Gln Arg Glu Pro Asp Glu Lys Glu 
    210                 215                 220                 


Lys Tyr Glu Met Tyr Ile Leu Phe Ser Tyr Met Lys Glu Asp Lys Arg 
225                 230                 235                 240 


Thr Lys Asn Thr Asp Leu Leu Val Lys Ser Ile Ser Asn Gln Asn Thr 
                245                 250                 255     


Lys Val Lys Val Glu Asp Ile Asp Gly Asn Lys Leu Leu Lys Leu Ser 
            260                 265                 270         


Ile Ala Asp Thr Lys Lys Lys Pro Leu Trp Glu Tyr Leu Ile Lys Tyr 
        275                 280                 285             


Ala Asp Ser Ser Arg Gln Arg Glu Leu Met Tyr Asp Ile Arg Lys Lys 
    290                 295                 300                 


Ile Ile Leu Tyr Val Ala Gly Ile Glu Glu Tyr Glu Asn Ile Lys Glu 
305                 310                 315                 320 


Asp Ser Gly Leu Ser Lys Val Ser Trp Ser Lys Tyr Asn Ile Ser Asp 
                325                 330                 335     


Asn Lys Met Phe Phe Asp Ile Asn Ser Cys Thr Asp Lys Arg Lys Gln 
            340                 345                 350         


Asn Leu Glu Ile Lys Ile Arg Glu Ala Asn Ile Glu His Tyr Arg Asn 
        355                 360                 365             


Ala Ser Ser Lys Leu Cys Asp Asp Glu Ser Ile Phe Trp Phe Gln His 
    370                 375                 380                 


Phe Glu Gly Val Ile Glu Thr Leu Phe Ser Lys Lys Ser Lys Ile Ser 
385                 390                 395                 400 


Glu Glu Arg Leu Gly Cys Ala Tyr Ile Cys Asp Tyr Leu Trp Lys Asp 
                405                 410                 415     


Phe Leu Ser Tyr Leu Ala Ala Lys Tyr Ile Asp Leu Gly Lys Gly Val 
            420                 425                 430         


Tyr His Phe Thr Met Lys Asp Lys Leu Asp Met Leu Asn Lys Asn Glu 
        435                 440                 445             


Ala Val Thr Asp Leu Arg Phe Gly Ile Val Ser Glu Lys Tyr Glu Lys 
    450                 455                 460                 


Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Glu Leu 
465                 470                 475                 480 


Asp Arg Asn Ile Ala Ala Tyr Val Thr Phe Ala Ala Asp Ile Phe Ala 
                485                 490                 495     


Lys Ser Val Ile Lys Ser Asp Tyr Arg Thr Lys Lys Asp Asn Asn Ser 
            500                 505                 510         


Asp Val Leu Gln Tyr Ser Asp Lys Lys Phe Arg Asn Ser Glu Val Ile 
        515                 520                 525             


Arg Asp Asn Ala Glu Lys Asn Ile Leu Gln Tyr Trp Gly Gly Tyr Ser 
    530                 535                 540                 


Arg Trp Gly Thr Glu Asn Ser Lys Leu Pro Glu Asn Asn Lys Val Ser 
545                 550                 555                 560 


Asp Phe Gly Lys Leu Asp Val Ser Asp Leu Cys Ile Asp Ile Lys Lys 
                565                 570                 575     


His Leu Ala Gly Ile Arg Asn Ser Ser Val His Tyr Thr Thr Lys Ile 
            580                 585                 590         


Lys Asn Glu Ser Ala Ala Asp Gly Ser Asn Val Lys Ile Leu Phe Glu 
        595                 600                 605             


Lys Asp Leu Ala Asp Ile Asn Ile Ile Tyr Ala Asp Lys Tyr Tyr Ser 
    610                 615                 620                 


Asn Asn Val Trp Met Phe Tyr Ser Leu Glu Asp Ile Asn Lys Leu Ile 
625                 630                 635                 640 


Ala Phe Leu Tyr Lys Glu Lys Arg Val Ile Arg Gln Val Gln Ile Pro 
                645                 650                 655     


Ser Phe Ser Arg Ile Leu Lys Arg Lys Ala Met Gln Asp Val Ile Asn 
            660                 665                 670         


Glu Ile Phe Lys Asp Asp Phe Asp Glu Asn Ile Val Asn Pro Glu Leu 
        675                 680                 685             


Lys Glu Lys Tyr Arg Asn Ser Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
    690                 695                 700                 


Tyr Asn Ala Phe Ile Ile Gln Pro Glu Leu Lys Glu Lys Phe Lys Asp 
705                 710                 715                 720 


Lys Ile Lys Thr Met Lys Ser Glu Leu Tyr Asn Lys Leu Lys Thr Ile 
                725                 730                 735     


Asp Lys Lys Glu Tyr Lys Ala Leu Tyr Cys Met Leu Ser Asn Glu Glu 
            740                 745                 750         


Ser Ala Leu Lys Asn Phe Ala Asp Arg Ile Tyr Ser Val Asp Gly Asp 
        755                 760                 765             


Asn Val Ser Phe Ala Asp Ile Cys Lys Ile Leu Met Thr Asp Tyr Asn 
    770                 775                 780                 


Met Gln Asn Gln Glu Lys Lys Asn Ile Glu Ser Met Glu Gln Lys Lys 
785                 790                 795                 800 


Lys Asn Lys Gly Lys Asp Glu Asn Tyr Lys His Phe Pro Leu Leu Leu 
                805                 810                 815     


His Lys Val Leu Lys Glu Leu Phe Ile Glu Tyr Leu Lys Gln Thr His 
            820                 825                 830         


Glu Leu Glu Phe Leu Arg Asn Asn Ile Cys Ile Lys Ser Asp Val Thr 
        835                 840                 845             


Met Glu Ser Phe Glu Ser Gln Ile Lys Gly Val Glu Ile Tyr Lys Asp 
    850                 855                 860                 


Leu Lys Glu Lys Ile Asp Lys Asn Asn Ser Leu Leu Asp Trp Tyr Val 
865                 870                 875                 880 


Ile Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asn 
                885                 890                 895     


Ile Lys Asn Tyr Ile Gln Phe Ala Thr Asn Ile Asp Lys Arg Ala Glu 
            900                 905                 910         


Ser Val Lys Asn Leu Thr Glu Ser Gly Met Val Lys Lys Ile Gln Tyr 
        915                 920                 925             


Tyr Asp Asp Ile Val Arg Thr Leu Glu Phe Ser Ala Gln Tyr Ile Gly 
    930                 935                 940                 


Lys Ile Ser Asn Asn Ile Asn Asp Tyr Phe Asn Ser Glu Asp Glu Tyr 
945                 950                 955                 960 


Val Ser Phe Leu Ser Lys Tyr Val Gly Phe Ile Asn Asp Lys Ser Glu 
                965                 970                 975     


Asp Val Leu Thr Glu Leu Lys Asp Phe Cys Arg Glu Lys Ile Asn Asn 
            980                 985                 990         


Ser Ser Gln Ile Ile Gly Ile Tyr  Tyr Gly Gly Asp Asn  Val Ile Ile 
        995                 1000                 1005             


Asn Arg  Asn Val Ile Tyr Ala  Gln Met Tyr Ser Asn  Ala Glu Val 
    1010                 1015                 1020             


Phe Ser  Asn Ile Tyr Lys Lys  Val Thr Lys Asn Asp  Ile Ile Asn 
    1025                 1030                 1035             


Tyr Tyr  Glu Lys Gln Asn Asp  Leu Lys Asp Val Phe  Lys Ser Gly 
    1040                 1045                 1050             


Val Cys  Gln Asn Glu Gly Glu  Gln Arg Ser Leu Cys  Glu Phe Gln 
    1055                 1060                 1065             


Gln Leu  Lys Asn Arg Ile Glu  Leu Thr Glu Leu Ser  Thr Tyr Ala 
    1070                 1075                 1080             


Asp Met  Val Asn Asp Phe Met  Ala Gln Phe Val Glu  Trp Ala Tyr 
    1085                 1090                 1095             


Leu Arg  Glu Arg Asp Leu Met  Tyr Phe Gln Leu Gly  Ile His Tyr 
    1100                 1105                 1110             


Ile Arg  Leu Phe Tyr Ser Asp  Asn Val Leu Asp Glu  Lys Tyr His 
    1115                 1120                 1125             


Lys Leu  Arg Asp Asn Val Ile  Asp Ile Glu Glu Gly  Ala Leu Leu 
    1130                 1135                 1140             


Tyr Gln  Ile Val Ala Met Tyr  Asp Tyr Glu Leu Arg  Ile Phe Glu 
    1145                 1150                 1155             


Thr Asp  Asn Ser Gly Asn Ala  Lys Arg Ile Gly Gln  Gly Gly Pro 
    1160                 1165                 1170             


Gly Lys  Ser Ile Pro Val Phe  Leu Lys Lys Tyr Cys  Asn Gly Thr 
    1175                 1180                 1185             


Asp Val  Tyr Glu Cys Gly Leu  Glu Leu Phe Glu Asp  Ile Asn Gln 
    1190                 1195                 1200             


His Glu  His Ile Ile Arg Phe  Arg Asn Asp Ile Ala  His Met Arg 
    1205                 1210                 1215             


Tyr Met  Ser Asn Gln Ala Met  Asn Ile Met Ser Ile  Val Ser Asn 
    1220                 1225                 1230             


Ile Tyr  Lys Ser Phe Phe Val  Tyr Asp Thr Lys Leu  Lys Lys Ser 
    1235                 1240                 1245             


Ile Ser  Leu Val Phe Lys Asn  Ile Leu Met Arg Tyr  Gly Val Ile 
    1250                 1255                 1260             


Ala Asp  Leu Val Phe Ser Tyr  Asn Asn Lys Asn Gln  Ser Ile Lys 
    1265                 1270                 1275             


Asp Asp  Met Asp Ile Asn Ile  Ile Asn Ile Lys Asn  Leu Lys Ser 
    1280                 1285                 1290             


Asp Lys  Tyr Val Tyr Lys Ile  Val Asn Glu Asp Ile  Val Lys Gln 
    1295                 1300                 1305             


Val Glu  Ile Glu Ile Arg Asn  Gln Val Phe Leu Glu  Gln Leu His 
    1310                 1315                 1320             


Lys Leu  Leu Tyr Phe Ser Arg  
    1325                 1330 


<210>  310
<211>  1221
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  310

Met Met Gln Ile Ile Lys Pro Tyr Gly Arg Ser Val Val Asp Thr Gly 
1               5                   10                  15      


Thr Gly Glu Pro Thr Gln Arg Lys Leu Gln Asp Lys Asn Gln Gln Gln 
            20                  25                  30          


His Asp Ile Ser Gln Phe Val His Glu His Ala Glu Leu Val Val Ala 
        35                  40                  45              


Gln Trp Ile Ser Val Ile Asp Lys Ile Ala Arg Lys Pro His Ala Asn 
    50                  55                  60                  


Gly Lys Asn Ala Gly Lys Cys Gly Leu Pro Thr Ala Gly Gln Tyr Gln 
65                  70                  75                  80  


Leu Arg Asp Ile Leu Gly Thr Ala Ala Trp Val Glu Val Leu Lys His 
                85                  90                  95      


Leu Ser Pro Gly Met Asp Ala Gln Arg Gln Gln Tyr Leu Glu Thr Leu 
            100                 105                 110         


Trp Tyr Ser Lys Ile His Pro Tyr Gly Lys Gln Thr Gln Glu Gln Glu 
        115                 120                 125             


Lys Ala Ile Pro Leu Gln Gly Arg Trp Tyr Gln Arg Phe Val Gly Asp 
    130                 135                 140                 


Val Leu Pro Glu Asn Val Asp Val Ala Leu Ala Lys Gln Val Ala Glu 
145                 150                 155                 160 


Arg Ile His Leu His Leu Tyr Glu Ala Ala Leu Arg Ile Asn Pro Glu 
                165                 170                 175     


Val Ser Ala Arg Arg Lys Gly Ser Ile Gln Ala Gln Ala Glu Thr Ile 
            180                 185                 190         


Thr Asn Asn Thr Leu His Pro Val Val Pro Pro Met Thr Trp Ser Lys 
        195                 200                 205             


Ala Asp Trp Ser Ala Tyr Asn Arg Tyr Asp Val Ala Glu Arg Ile Tyr 
    210                 215                 220                 


Leu Glu Ala Lys Tyr Arg Leu Glu Gln Lys Gln Asp Ala Arg Gln Lys 
225                 230                 235                 240 


Lys Gln Pro Ile Gln Pro Glu Trp Arg Ile Asp Gly Ser Leu Ala Gly 
                245                 250                 255     


Lys Leu Leu Phe Glu His Trp Ala Gln Val Phe Lys Gly Ser Asp Gly 
            260                 265                 270         


Lys Ser Arg Ile Ser Glu Ala Lys Thr His Ala Ala Gly Leu Phe Ala 
        275                 280                 285             


Leu His Met Ala Val Lys Asp Phe Tyr Thr Arg Leu Phe Asp Ser Asn 
    290                 295                 300                 


Arg Lys Glu Glu Thr Leu Val Lys Phe Leu Leu Pro Gln Lys Lys Lys 
305                 310                 315                 320 


Ala Leu Gln Glu Lys Leu Thr Gln Lys Leu Gln Asn Thr Asp Val Ala 
                325                 330                 335     


Ala Arg Ile Arg Leu Gly Lys Ile Gln Tyr Tyr Arg Lys Ala Gln Gly 
            340                 345                 350         


Glu Val Val Pro Leu Ala Asn Ser Arg Phe Trp Gly Ser Asp Gly Gln 
        355                 360                 365             


Ala Glu Ile Lys Arg Ala Glu Ala Phe Val Arg Val Trp Arg His Val 
    370                 375                 380                 


Leu Gly Gln Ala Asn Leu Thr Leu Ala Asn Trp Ala Ser Leu Ala Ser 
385                 390                 395                 400 


Pro Ala Asp Leu Trp Gly Gly Asp Ser Phe Phe Gly His Phe Ser Thr 
                405                 410                 415     


His Ile Asn Gly Lys Leu Phe Ala Thr Asp Ile Gly Leu Asp Ser Arg 
            420                 425                 430         


Arg Thr Val Phe Asp Gln Asn Leu His Leu Leu Phe Gly Asp Ala Ala 
        435                 440                 445             


Gly Leu Phe Gln Ser Asp Asp Glu Thr Arg Lys Ala Ser Ile Leu Leu 
    450                 455                 460                 


Ala His Lys Cys Gly Gly Ala Leu Arg Asn Ala Ala Phe His Phe Lys 
465                 470                 475                 480 


Gly Arg Ala Lys Phe Leu Gln Ala Leu Glu Asn Asp Leu Pro Gln Ala 
                485                 490                 495     


Ala Gln Ser Gly Leu Gln Met Gln Leu Ser Lys Leu Trp Asp Glu Ala 
            500                 505                 510         


Gln Asn Gln Gln Gly Ser Arg Leu Leu Lys Ile Leu Glu Gly Ala His 
        515                 520                 525             


Val Phe His Val Cys Thr Gln Glu Gln Val Gln Gln Leu Val Asn Thr 
    530                 535                 540                 


Leu Gly Asn Val Ser Ala Gly Glu Leu Pro Leu Pro Arg Phe Gly Arg 
545                 550                 555                 560 


Val Ile Glu Arg Asn His His Ala Arg Leu Gly Thr Asn Leu Pro Val 
                565                 570                 575     


Arg Gly Asn Arg Gln Ala Met Glu Gln His Pro Ala Arg Lys Cys Gln 
            580                 585                 590         


Tyr Val Met Leu Lys Leu Leu Tyr Glu Arg Ala Phe Arg Val Trp Leu 
        595                 600                 605             


Glu Asn Thr Thr Asp Glu Val Phe Ser Val Trp Leu Glu Thr Ala Leu 
    610                 615                 620                 


Glu Arg Thr Thr Asn Ala Ala Arg Asn Asn Pro Asn Val Gln Gly Lys 
625                 630                 635                 640 


Ser Gln His Glu Arg Glu Leu Val Met Ala Arg Ala Ala Lys Leu Pro 
                645                 650                 655     


Ile Ser Met Arg Ser Lys Gly Gly Lys Gly Lys Glu Lys Ser Ile Arg 
            660                 665                 670         


Gln Phe Phe Tyr Asp Leu Ser Ala Ala Thr Ala Ser Glu Met Arg Val 
        675                 680                 685             


Gln Arg Gly Tyr Ala Ser Asp Ala Gly Lys Ala Arg Glu Gln Ala Glu 
    690                 695                 700                 


Tyr Ile Asp Glu Leu Leu Arg Asp Val Val Ala Leu Ala Phe Arg Glu 
705                 710                 715                 720 


Phe Ile Arg Ala Asn Gly Phe Asp Trp Leu Leu Asp Ile Asp Pro Gln 
                725                 730                 735     


Gln Glu Leu Arg Glu Thr Arg Cys Cys Leu Met Glu His Ile Arg Phe 
            740                 745                 750         


Pro Ala Ile Ala Pro Arg Ser Asn Ala Trp Gln Pro Val Leu Tyr Phe 
        755                 760                 765             


Leu Leu His Leu Met Pro Val Gly Glu Val Ser Gln Leu Leu His Gln 
    770                 775                 780                 


Leu Ala Lys Trp Glu Ile Leu Ala Lys Pro Glu Gln Ala Arg Thr Asp 
785                 790                 795                 800 


Glu Glu Gly Met Arg Leu His Ala Leu Gln Gln Thr Leu Lys Leu Tyr 
                805                 810                 815     


Leu Asp Met His Asp Ser His Tyr Thr Gly Ala Glu Ser Met Pro Ala 
            820                 825                 830         


Val Glu Arg Ala Val Leu Asp Thr Phe Ala Thr Phe Tyr Glu Thr Arg 
        835                 840                 845             


Asn Gly Leu Asp Lys Val Phe Glu Asp Gln Gly Asn Gly Arg Asp Gly 
    850                 855                 860                 


Ala Arg Tyr Leu Pro Gln Arg Gly Leu Arg Glu Ile Arg Arg Phe Gly 
865                 870                 875                 880 


His Val Pro Val Leu Gln Ala Leu Val Lys Asp Lys Ile Thr Ala Gln 
                885                 890                 895     


Asp Val Thr His Cys Leu Gln Gln Glu Thr Val Pro Ala Asn Gly Lys 
            900                 905                 910         


Leu Ser Pro Val Ala Gln Ala Gln Gln Arg Arg Glu Thr Leu His Gly 
        915                 920                 925             


Glu Trp Val Lys Glu Arg Lys Gln Phe Lys Ala Tyr Arg Asp Tyr Ala 
    930                 935                 940                 


Ala Ala Leu Gln Thr Val Val Val His Arg Gln Leu Ser Asn His Ile 
945                 950                 955                 960 


Arg Leu Val Asp His Val Ala Ala His Arg Ile Val Met Lys Val Leu 
                965                 970                 975     


Ala Arg Leu Ala Asp Phe Ser Gly Leu Phe Glu Arg Asp Leu Thr Phe 
            980                 985                 990         


Val Thr Leu Ala Ala Leu His Glu  His Gln Leu Gln Pro  Glu Asp Phe 
        995                 1000                 1005             


Phe Val  Ile Asp Asn Pro Pro  Arg Tyr Asn Asn Arg  Gly Glu Leu 
    1010                 1015                 1020             


Glu Lys  Asp Gly Leu Thr Leu  Phe Lys Asn Gly Gln  Val Ile Glu 
    1025                 1030                 1035             


Ala Leu  Gly Lys Val Gln Ala  Cys Arg Asp Ala Leu  Lys His Gln 
    1040                 1045                 1050             


Ile Val  Gly Gln Val Asn Leu  Asp Val His Arg Ser  Val Arg Asn 
    1055                 1060                 1065             


Asp Phe  Ala His Phe Asn Met  Leu Tyr Gly Lys Gln  Arg Thr Thr 
    1070                 1075                 1080             


Glu Ser  Ala Thr Asn Arg Val  Ile Lys Cys Pro Ala  Ala Gln Gly 
    1085                 1090                 1095             


Leu Asn  Leu Thr Cys Trp Val  Asn Cys Ala Arg Asn  Leu Met Ser 
    1100                 1105                 1110             


Tyr Asp  Arg Lys Leu Lys Asn  Ala Val Ser Gln Ser  Ile Ile Glu 
    1115                 1120                 1125             


Leu Met  Glu Arg Glu Gly Phe  Ile Leu Thr Trp Glu  Met Asp Thr 
    1130                 1135                 1140             


Asn His  Gln Leu Cys Ser Pro  Lys Leu Gln Ser Arg  Gln Val Glu 
    1145                 1150                 1155             


His Leu  Gly Gly Gln Arg Phe  Pro Leu Val Lys Asp  Glu Arg Lys 
    1160                 1165                 1170             


Lys Leu  Thr Ile Arg Glu Asn  Leu His Ser Val Gly  Met Val Lys 
    1175                 1180                 1185             


Leu Leu  Ala His Ala Phe Gly  Ala Val Ala Glu Asp  Val Lys Asp 
    1190                 1195                 1200             


Ile Ser  Thr Leu Asp Leu Asn  Thr Val Lys Trp Val  Lys Lys Asp 
    1205                 1210                 1215             


Ala Thr  Leu 
    1220     


<210>  311
<211>  1384
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  311

Met Gly Asn Leu Phe Gly His Lys Arg Trp Tyr Glu Val Ser Asp Arg 
1               5                   10                  15      


Glu Asn Tyr Lys Ile Lys Arg Lys Val Lys Val Lys Arg Asn Tyr Asp 
            20                  25                  30          


Gly Asn Lys Tyr Ile Leu Asn Ile Asn Glu Asn Asn Asn Lys Glu Lys 
        35                  40                  45              


Ile Asp Asn Asn Glu Phe Ile Glu Glu Leu Val Asn Tyr Lys Lys Asn 
    50                  55                  60                  


Asn Asn Val Leu Arg Glu Phe Lys Arg Lys Phe His Ala Arg Asn Ile 
65                  70                  75                  80  


Leu Phe Lys Leu Lys Gly Asn Lys Arg Ser Ile Glu Asp Ser Asn Asp 
                85                  90                  95      


Phe Leu Lys Thr Glu Glu Val Val Leu Asp Lys Glu Ile Tyr Gly Gln 
            100                 105                 110         


Ser Glu Lys Leu Arg Asn Glu Lys Gly Ile Thr Lys Lys Asp Ile Leu 
        115                 120                 125             


Lys Glu Ile Asn Lys Gln Lys Ile Asp Asn Ser Val Lys Lys Ile Ser 
    130                 135                 140                 


Met Asn Thr Asn Ser Gly Lys Thr Ile Val Ile Asn Phe Ser Asp Lys 
145                 150                 155                 160 


Leu Lys Lys Asp Lys Asp Asp Tyr Gln Ile Thr Leu Asn Ile Ile Ser 
                165                 170                 175     


Glu Asp Glu Leu Glu Arg Lys Arg Lys Ile Tyr Asp Ile Phe Lys Met 
            180                 185                 190         


Ile Asn Met Asp Leu Tyr Gln Ile Ile Lys Glu Ile Ile Glu Asn Gln 
        195                 200                 205             


Val Gln Lys Val Phe Lys Asn Arg Tyr Tyr Glu Glu His Leu Arg Glu 
    210                 215                 220                 


Lys Leu Leu Lys Asp Asp Lys Met Asp Val Ile Leu Thr Asn Phe Met 
225                 230                 235                 240 


Lys Ile Arg Glu Lys Ile Glu Ser Asn Pro Glu Ile Met Gly Phe Val 
                245                 250                 255     


Lys Phe Tyr Leu Asn Val Gly Gly Asp Lys Lys Lys Ser Glu Asn Lys 
            260                 265                 270         


Lys Met Phe Val Glu Lys Ile Leu Asn Ile Asn Val Asp Leu Thr Val 
        275                 280                 285             


Glu Asp Ile Val Asp Phe Ile Val Lys Glu Leu Lys Phe Trp Asn Ile 
    290                 295                 300                 


Thr Lys Arg Ile Glu Lys Val Lys Glu Phe Asn Asn Lys Phe Leu Glu 
305                 310                 315                 320 


Asn Lys Arg Asn Arg Thr Tyr Ile Lys Ser Tyr Val Leu Leu Asp Lys 
                325                 330                 335     


His Glu Lys Phe Lys Ile Glu Arg Glu Asn Lys Lys Asp Lys Ile Val 
            340                 345                 350         


Lys Phe Phe Val Glu Asn Ile Lys Asn Asn Ser Ile Lys Glu Lys Ile 
        355                 360                 365             


Glu Lys Ile Leu Ala Glu Phe Lys Ile Asp Glu Leu Thr Lys Lys Leu 
    370                 375                 380                 


Glu Lys Gly Asn Cys Asp Thr Glu Ile Phe Gly Ile Phe Lys Lys His 
385                 390                 395                 400 


Tyr Lys Val Asn Phe Asp Ser Lys Lys Phe Glu Asn Lys Ser Asp Glu 
                405                 410                 415     


Glu Lys Glu Leu Tyr Lys Ile Ile Tyr Arg Tyr Leu Lys Gly Arg Ile 
            420                 425                 430         


Glu Lys Ile Leu Ile Asn Glu Glu Lys Val Arg Leu Lys Lys Met Glu 
        435                 440                 445             


Lys Ile Glu Ile Glu Lys Ile Leu Asn Glu Ser Ile Leu Ser Glu Lys 
    450                 455                 460                 


Ile Leu Lys Arg Val Lys Gln Tyr Thr Leu Glu His Ile Met Tyr Leu 
465                 470                 475                 480 


Gly Lys Leu Val His Asn Lys Ile Asn Met Ala Thr Val Asn Thr Asn 
                485                 490                 495     


Asp Phe Phe Arg Leu His Ala Lys Glu Glu Leu Asp Leu Glu Leu Ile 
            500                 505                 510         


Thr Phe Leu Ala Ser Thr Asn Met Glu Leu Asn Lys Ile Phe Asn Gly 
        515                 520                 525             


Lys Glu Lys Val Thr Asp Phe Phe Gly Phe Asn Leu Asn Gly Gln Lys 
    530                 535                 540                 


Ile Thr Leu Lys Glu Lys Val Pro Ser Phe Lys Leu Asn Ile Leu Lys 
545                 550                 555                 560 


Lys Leu Asn Phe Ile Asn Asn Glu Asn Asn Ile Asp Glu Lys Leu Ser 
                565                 570                 575     


His Phe Tyr Ser Phe Gln Lys Lys Gly Tyr Leu Leu Arg Asn Lys Ile 
            580                 585                 590         


Leu His Asn Ser Tyr Gly Asn Ile Gln Glu Thr Ile Asn Leu Lys Gly 
        595                 600                 605             


Glu Tyr Glu Asn Val Glu Asn Leu Ile Lys Glu Leu Lys Val Ser Asn 
    610                 615                 620                 


Glu Glu Ile Ser Lys Ser Leu Asn Leu Asp Ile Ile Phe Glu Gly Lys 
625                 630                 635                 640 


Val Asp Ile Ile Asn Lys Ile Asn Ser Leu Glu Ile Gly Glu Tyr Lys 
                645                 650                 655     


Asp Lys Lys Tyr Leu Pro Ser Phe Ser Lys Ile Val Pro Glu Ile Met 
            660                 665                 670         


Arg Lys Phe Arg Glu Ile Asn Lys Asp Lys Ser Phe Asp Ile Glu Ser 
        675                 680                 685             


Glu Lys Ile Ile Leu Asn Ala Val Gln Tyr Val Asn Lys Ile Leu Tyr 
    690                 695                 700                 


Glu Lys Ile Thr Ser Asn Glu Glu Asn Glu Phe Ile Lys Thr Leu Pro 
705                 710                 715                 720 


Asp Lys Leu Val Lys Lys Asn Asn Asn Lys Glu Asn Asn Asn Ser Leu 
                725                 730                 735     


Ser Ile Glu Glu Tyr Tyr Lys Asn Ala Gln Ile Ser Ser Ser Lys Gly 
            740                 745                 750         


Asp Lys Lys Ala Ile Lys Lys Tyr Gln Asn Lys Val Thr Asn Ala Tyr 
        755                 760                 765             


Ile Glu Tyr Leu Glu Asn Thr Phe Ala Glu Val Ile Asp Phe Ser Asn 
    770                 775                 780                 


Phe Asn Leu Asn Phe Asp Glu Ile Lys Thr Lys Ile Glu Glu Arg Lys 
785                 790                 795                 800 


Tyr Ser Lys Ser Lys Ile Thr Val Asp Ser Ile Ser Thr Asn Ile Asn 
                805                 810                 815     


Ile Thr Asn Asp Ile Glu Tyr Ile Ile Ser Ile Phe Ala Leu Leu Asn 
            820                 825                 830         


Ser Asn Thr Tyr Ile Asn Lys Ile Arg Asn Arg Phe Phe Ala Thr Ser 
        835                 840                 845             


Val Trp Leu Asp Lys Gln Asn Ser Thr Lys Glu Tyr Asp Tyr Glu Asn 
    850                 855                 860                 


Ile Ile Asp Ile Leu Asp Lys Ile Leu Ser Ile Asn Leu Leu Arg Glu 
865                 870                 875                 880 


Asn Asn Ile Ala Asp Ile Leu Asp Leu Lys Asn Thr Ile Ile Glu Ala 
                885                 890                 895     


Lys Ile Val Glu Asn Asn Glu Glu Cys Ile Lys Asn Tyr Ile Phe Glu 
            900                 905                 910         


Asn Asn Glu Glu Glu Leu Lys Lys Arg Leu Phe Cys Glu Glu Leu Val 
        915                 920                 925             


Asn Lys Glu Asp Val Leu Lys Ile Phe Glu Asp Lys Asn Phe Lys Phe 
    930                 935                 940                 


Lys Asn Phe Ile Lys Lys Thr Gly Asn Glu Asn Phe Thr Ile Asn Phe 
945                 950                 955                 960 


Asp Ile Leu Phe Asn Leu Glu Cys Asn Ser Glu Leu Asn Val Lys Lys 
                965                 970                 975     


Val Met Gly Gln Asn Ser Gln Arg Leu Asn Leu Phe Ile Lys Asn Thr 
            980                 985                 990         


Ile Asp Glu Tyr Lys Ser Lys Ile  Lys Thr Ser Phe Ser  Ser Glu Phe 
        995                 1000                 1005             


Leu Glu  Lys Tyr Lys Lys Glu  Ile Asp Asn Leu Val  Glu Asp Thr 
    1010                 1015                 1020             


Glu Ser  Glu Asn Lys Asn Lys  Phe Glu Lys Ile Tyr  Tyr Pro Lys 
    1025                 1030                 1035             


Glu His  Lys Asn Glu Leu Tyr  Ile Tyr Lys Lys Asn  Leu Phe Leu 
    1040                 1045                 1050             


Asn Ile  Gly Asn Pro Asn Phe  Asp Lys Ile Tyr Glu  Leu Ile Ser 
    1055                 1060                 1065             


Lys Asp  Ile Lys Asn Ala Asn  Thr Glu Ile Leu Phe  Asp Asp Asp 
    1070                 1075                 1080             


Ile Arg  Lys Asn Lys Ile Ser  Glu Ile Asp Ala Ile  Leu Lys Asn 
    1085                 1090                 1095             


Leu Asn  Asp Lys Leu Asn Gly  Tyr Ser Asn Asp Tyr  Lys Ala Lys 
    1100                 1105                 1110             


Tyr Val  Asn Lys Leu Lys Glu  Asn Asp Asp Phe Phe  Ala Lys Asn 
    1115                 1120                 1125             


Met Lys  Asn Glu Asn Tyr Ser  Ser Phe Gly Glu Phe  Glu Lys Asp 
    1130                 1135                 1140             


Tyr Asn  Lys Val Ser Glu Tyr  Lys Lys Ile Arg Asp  Leu Val Glu 
    1145                 1150                 1155             


Phe Asn  Tyr Leu Asn Lys Ile  Glu Ser Tyr Leu Ile  Asp Ile Asn 
    1160                 1165                 1170             


Trp Lys  Leu Ala Ile Gln Met  Ala Arg Phe Glu Arg  Asp Met His 
    1175                 1180                 1185             


Tyr Ile  Val Asn Gly Leu Arg  Glu Leu Gly Ile Ile  Lys Leu Ser 
    1190                 1195                 1200             


Gly Tyr  Asn Thr Gly Ile Ser  Arg Ala Tyr Pro Lys  Arg Asn Gly 
    1205                 1210                 1215             


Ser Asp  Gly Phe Tyr Thr Thr  Thr Ala Tyr Tyr Lys  Phe Phe Asp 
    1220                 1225                 1230             


Glu Glu  Ser Tyr Lys Lys Phe  Glu Lys Ile Cys Tyr  Gly Phe Gly 
    1235                 1240                 1245             


Ile Asp  Leu Ser Glu Asn Ser  Glu Ile Asn Lys Pro  Glu Asn Glu 
    1250                 1255                 1260             


Ser Ile  Arg Asn Tyr Ile Ser  His Phe Tyr Ile Val  Arg Asn Pro 
    1265                 1270                 1275             


Phe Val  Asp Tyr Ser Ile Ala  Glu Gln Ile Asp Arg  Val Ser Asn 
    1280                 1285                 1290             


Leu Leu  Ser Tyr Ser Thr Arg  Tyr Asn Asn Ser Thr  Tyr Ala Ser 
    1295                 1300                 1305             


Val Phe  Glu Val Phe Lys Lys  Asp Val Asn Leu Asp  Tyr Asp Lys 
    1310                 1315                 1320             


Leu Lys  Thr Lys Phe Lys Leu  Phe Asp Asp Glu Lys  Asn Asp Asn 
    1325                 1330                 1335             


Ile Lys  Ile Leu Lys Ile Glu  Asn Leu Ile Glu Ser  Lys Lys Val 
    1340                 1345                 1350             


Ser Val  Leu Glu Leu Glu Ser  Tyr Asn Ser Asp Tyr  Ile Lys Asn 
    1355                 1360                 1365             


Leu Ile  Ile Glu Leu Leu Thr  Lys Ile Glu Asn Thr  Asn Asp Thr 
    1370                 1375                 1380             


Leu 
    


<210>  312
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  312

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Glu 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Met Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro Tyr Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Ala Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Thr Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Glu Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Lys  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  313
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  313

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Asp Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Thr 
        115                 120                 125             


Lys Asp Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His 
            180                 185                 190         


Glu Arg Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Glu Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Arg 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Lys 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Thr Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Phe Asp Phe Lys Leu  Leu Asn 
    1370                 1375                 1380         


<210>  314
<211>  1221
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  314

Met Met Gln Ile Ile Lys Pro Tyr Gly Arg Ser Val Val Asp Thr Gly 
1               5                   10                  15      


Thr Gly Glu Pro Thr Gln Arg Lys Leu Gln Asp Lys Asn Gln Gln Gln 
            20                  25                  30          


His Asp Ile Ser Gln Phe Val His Glu His Ala Glu Leu Val Val Ala 
        35                  40                  45              


Gln Trp Ile Ser Val Ile Asp Lys Ile Ala Arg Lys Pro His Ala Asn 
    50                  55                  60                  


Gly Lys Asn Ala Gly Lys Cys Gly Leu Pro Thr Ala Gly Gln Tyr Gln 
65                  70                  75                  80  


Leu Arg Asp Ile Leu Gly Thr Ala Ala Trp Val Glu Val Leu Lys His 
                85                  90                  95      


Leu Ser Pro Gly Met Asp Ala Gln Arg Gln Gln Tyr Leu Glu Thr Leu 
            100                 105                 110         


Trp Tyr Ser Lys Ile His Pro Tyr Gly Lys Gln Thr Gln Glu Gln Glu 
        115                 120                 125             


Lys Ala Ile Pro Leu Gln Gly Arg Trp Tyr Gln Arg Phe Val Gly Asp 
    130                 135                 140                 


Val Leu Pro Glu Asn Val Asp Val Ala Leu Ala Lys Gln Val Ala Glu 
145                 150                 155                 160 


Arg Ile His Leu His Leu Tyr Glu Ala Ala Leu Arg Ile Asn Pro Glu 
                165                 170                 175     


Val Ser Ala Arg Arg Lys Gly Ser Ile Gln Ala Gln Ala Glu Thr Ile 
            180                 185                 190         


Thr Asn Asn Thr Leu His Pro Val Val Pro Pro Met Thr Trp Ser Lys 
        195                 200                 205             


Ala Asp Trp Ser Ala Tyr Asn Arg Tyr Asp Val Ala Glu Arg Ile Tyr 
    210                 215                 220                 


Leu Glu Ala Lys Tyr Arg Leu Glu Gln Lys Gln Asp Ala Arg Gln Lys 
225                 230                 235                 240 


Lys Gln Pro Ile Gln Pro Glu Trp Arg Ile Asp Gly Ser Leu Ala Gly 
                245                 250                 255     


Lys Leu Leu Phe Glu His Trp Ala Gln Val Phe Lys Gly Ser Asp Gly 
            260                 265                 270         


Lys Ser Arg Ile Ser Glu Ala Lys Thr His Ala Ala Gly Leu Phe Ala 
        275                 280                 285             


Leu His Met Ala Val Lys Asp Phe Tyr Thr Arg Leu Phe Asp Ser Asn 
    290                 295                 300                 


Arg Lys Glu Glu Thr Leu Val Lys Phe Leu Leu Pro Gln Lys Lys Lys 
305                 310                 315                 320 


Ala Leu Gln Glu Lys Leu Thr Gln Lys Leu Gln Asn Thr Asp Val Ala 
                325                 330                 335     


Ala Arg Ile Arg Leu Gly Lys Ile Gln Tyr Tyr Arg Lys Ala Gln Gly 
            340                 345                 350         


Glu Val Val Pro Leu Ala Asn Ser Arg Phe Trp Gly Ser Asp Gly Gln 
        355                 360                 365             


Ala Glu Ile Lys Arg Ala Glu Ala Phe Val Arg Val Trp Arg His Val 
    370                 375                 380                 


Leu Gly Gln Ala Asn Leu Thr Leu Ala Asn Trp Ala Ser Leu Ala Ser 
385                 390                 395                 400 


Pro Ala Asp Leu Trp Gly Gly Asp Ser Phe Phe Gly His Phe Ser Thr 
                405                 410                 415     


His Ile Asn Gly Lys Leu Phe Ala Thr Asp Ile Gly Leu Asp Ser Arg 
            420                 425                 430         


Arg Thr Val Phe Asp Gln Asn Leu His Leu Leu Phe Gly Asp Ala Ala 
        435                 440                 445             


Gly Leu Phe Gln Ser Asp Asp Glu Thr Arg Lys Ala Ser Ile Leu Leu 
    450                 455                 460                 


Ala His Lys Cys Gly Gly Ala Leu Arg Asn Ala Ala Phe His Phe Lys 
465                 470                 475                 480 


Gly Arg Ala Lys Phe Leu Gln Ala Leu Glu Asn Asp Leu Pro Gln Ala 
                485                 490                 495     


Ala Gln Ser Gly Leu Gln Met Gln Leu Ser Lys Leu Trp Asp Glu Ala 
            500                 505                 510         


Gln Asn Gln Gln Gly Ser Arg Leu Leu Lys Ile Leu Glu Gly Ala His 
        515                 520                 525             


Val Phe His Val Cys Thr Gln Glu Gln Val Gln Gln Leu Val Asn Thr 
    530                 535                 540                 


Leu Gly Asn Val Ser Ala Gly Glu Leu Pro Leu Pro Arg Phe Gly Arg 
545                 550                 555                 560 


Val Ile Glu Arg Asn His His Ala Arg Leu Gly Thr Asn Leu Pro Val 
                565                 570                 575     


Arg Gly Asn Arg Gln Ala Met Glu Gln His Pro Ala Arg Lys Cys Gln 
            580                 585                 590         


Tyr Val Met Leu Lys Leu Leu Tyr Glu Arg Ala Phe Arg Val Trp Leu 
        595                 600                 605             


Glu Asn Thr Thr Asp Glu Val Phe Ser Val Trp Leu Glu Thr Ala Leu 
    610                 615                 620                 


Glu Arg Thr Thr Asn Ala Ala Arg Asn Asn Pro Asn Val Gln Gly Lys 
625                 630                 635                 640 


Ser Gln His Glu Arg Glu Leu Val Met Ala Arg Ala Ala Lys Leu Pro 
                645                 650                 655     


Ile Ser Met Arg Ser Lys Gly Gly Lys Gly Lys Glu Lys Ser Ile Arg 
            660                 665                 670         


Gln Phe Phe Tyr Asp Leu Ser Ala Ala Thr Ala Ser Glu Met Arg Val 
        675                 680                 685             


Gln Arg Gly Tyr Ala Ser Asp Ala Gly Lys Ala Arg Glu Gln Ala Glu 
    690                 695                 700                 


Tyr Ile Asp Glu Leu Leu Arg Asp Val Val Ala Leu Ala Phe Arg Glu 
705                 710                 715                 720 


Phe Ile Arg Ala Asn Gly Phe Asp Trp Leu Leu Asp Ile Asp Pro Gln 
                725                 730                 735     


Gln Glu Leu Arg Glu Thr Arg Cys Cys Leu Met Glu His Ile Arg Phe 
            740                 745                 750         


Pro Ala Ile Ala Pro Arg Ser Asn Ala Trp Gln Pro Val Leu Tyr Phe 
        755                 760                 765             


Leu Leu His Leu Met Pro Val Gly Glu Val Ser Gln Leu Leu His Gln 
    770                 775                 780                 


Leu Ala Lys Trp Glu Ile Leu Ala Lys Pro Glu Gln Ala Arg Thr Asp 
785                 790                 795                 800 


Glu Glu Gly Met Arg Leu His Ala Leu Gln Gln Thr Leu Lys Leu Tyr 
                805                 810                 815     


Leu Asp Met His Asp Ser His Tyr Thr Gly Ala Glu Ser Met Pro Ala 
            820                 825                 830         


Val Glu Arg Ala Val Leu Asp Thr Phe Ala Thr Phe Tyr Glu Thr Arg 
        835                 840                 845             


Asn Gly Leu Asp Lys Val Phe Glu Asp Gln Gly Asn Gly Arg Asp Gly 
    850                 855                 860                 


Ala Arg Tyr Leu Pro Gln Arg Gly Leu Arg Glu Ile Arg Arg Phe Gly 
865                 870                 875                 880 


His Val Pro Val Leu Gln Ala Leu Val Lys Asp Lys Ile Thr Ala Gln 
                885                 890                 895     


Asp Val Thr His Cys Leu Gln Gln Glu Thr Val Pro Ala Asn Gly Lys 
            900                 905                 910         


Leu Ser Pro Val Ala Gln Ala Gln Gln Arg Arg Glu Thr Leu His Gly 
        915                 920                 925             


Glu Trp Val Lys Glu Arg Lys Gln Phe Lys Ala Tyr Arg Asp Tyr Ala 
    930                 935                 940                 


Ala Ala Leu Gln Thr Val Val Val His Arg Gln Leu Ser Asn His Ile 
945                 950                 955                 960 


Arg Leu Val Asp His Val Ala Ala His Arg Ile Val Met Lys Val Leu 
                965                 970                 975     


Ala Arg Leu Ala Asp Phe Ser Gly Leu Phe Glu Arg Asp Leu Thr Phe 
            980                 985                 990         


Val Thr Leu Ala Ala Leu His Glu  His Gln Leu Gln Pro  Glu Asp Phe 
        995                 1000                 1005             


Phe Val  Ile Asp Asn Pro Pro  Arg Tyr Asn Asn Arg  Gly Glu Leu 
    1010                 1015                 1020             


Glu Lys  Asp Gly Leu Thr Leu  Phe Lys Asn Gly Gln  Val Ile Glu 
    1025                 1030                 1035             


Ala Leu  Gly Lys Val Gln Ala  Cys Arg Asp Ala Leu  Lys His Gln 
    1040                 1045                 1050             


Ile Val  Gly Gln Val Asn Leu  Asp Val His Arg Ser  Val Arg Asn 
    1055                 1060                 1065             


Asp Phe  Ala His Phe Asn Met  Leu Tyr Gly Lys Gln  Arg Thr Thr 
    1070                 1075                 1080             


Glu Ser  Ala Thr Asn Arg Val  Ile Lys Cys Pro Ala  Ala Gln Gly 
    1085                 1090                 1095             


Leu Asn  Leu Thr Cys Trp Val  Asn Cys Ala Arg Asn  Leu Met Ser 
    1100                 1105                 1110             


Tyr Asp  Arg Lys Leu Lys Asn  Ala Val Ser Gln Ser  Ile Ile Glu 
    1115                 1120                 1125             


Leu Met  Glu Arg Glu Gly Phe  Ile Leu Thr Trp Glu  Met Asp Thr 
    1130                 1135                 1140             


Asn His  Gln Leu Cys Ser Pro  Lys Leu Gln Ser Arg  Gln Val Glu 
    1145                 1150                 1155             


His Leu  Gly Gly Gln Arg Phe  Pro Leu Val Lys Asp  Glu Arg Lys 
    1160                 1165                 1170             


Lys Leu  Thr Ile Arg Glu Asn  Leu His Ser Val Gly  Met Val Lys 
    1175                 1180                 1185             


Leu Leu  Ala His Ala Phe Gly  Ala Val Ala Glu Asp  Val Lys Asp 
    1190                 1195                 1200             


Ile Ser  Thr Leu Asp Leu Asn  Thr Val Lys Trp Val  Lys Lys Asp 
    1205                 1210                 1215             


Ala Thr  Leu 
    1220     


<210>  315
<211>  1221
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  315

Met Met Gln Ile Ile Lys Pro Tyr Gly Arg Ser Val Val Asp Thr Gly 
1               5                   10                  15      


Thr Gly Glu Pro Thr Gln Arg Lys Leu Gln Asp Lys Asn Gln Gln Gln 
            20                  25                  30          


His Asp Ile Ser Gln Phe Val His Glu His Ala Glu Leu Val Val Ala 
        35                  40                  45              


Gln Trp Ile Ser Val Ile Asp Lys Ile Ala Arg Lys Pro His Ala Asn 
    50                  55                  60                  


Gly Lys Asn Ala Gly Lys Cys Gly Leu Pro Thr Ala Gly Gln Tyr Gln 
65                  70                  75                  80  


Leu Arg Asp Ile Leu Gly Thr Ala Ala Trp Val Glu Val Leu Lys His 
                85                  90                  95      


Leu Ser Pro Gly Met Asp Ala Gln Arg Gln Gln Tyr Leu Glu Thr Leu 
            100                 105                 110         


Trp Tyr Ser Lys Ile His Pro Tyr Gly Lys Gln Thr Gln Glu Gln Glu 
        115                 120                 125             


Lys Ala Ile Pro Leu Gln Gly Arg Trp Tyr Gln Arg Phe Val Gly Asp 
    130                 135                 140                 


Val Leu Pro Glu Asn Val Asp Val Ala Leu Ala Lys Gln Val Ala Glu 
145                 150                 155                 160 


Arg Ile His Leu His Leu Tyr Glu Ala Ala Leu Arg Ile Asn Pro Glu 
                165                 170                 175     


Val Ser Ala Arg Arg Lys Gly Ser Ile Gln Ala Gln Ala Glu Thr Ile 
            180                 185                 190         


Thr Asn Asn Thr Leu His Pro Val Val Pro Pro Met Thr Trp Ser Lys 
        195                 200                 205             


Ala Asp Trp Ser Ala Tyr Asn Arg Tyr Asp Val Ala Glu Arg Ile Tyr 
    210                 215                 220                 


Leu Glu Ala Lys Tyr Arg Leu Glu Gln Lys Gln Asp Ala Arg Gln Lys 
225                 230                 235                 240 


Lys Gln Pro Ile Gln Pro Glu Trp Arg Ile Asp Gly Ser Leu Ala Gly 
                245                 250                 255     


Lys Leu Leu Phe Glu His Trp Ala Gln Val Phe Lys Gly Ser Asp Gly 
            260                 265                 270         


Lys Ser Arg Ile Ser Glu Ala Lys Thr His Ala Ala Gly Leu Phe Ala 
        275                 280                 285             


Leu His Met Ala Val Lys Asp Phe Tyr Thr Arg Leu Phe Asp Ser Asn 
    290                 295                 300                 


Arg Lys Glu Glu Thr Leu Val Lys Phe Leu Leu Pro Gln Lys Lys Lys 
305                 310                 315                 320 


Ala Leu Gln Glu Lys Leu Thr Gln Lys Leu Gln Asn Thr Asp Val Ala 
                325                 330                 335     


Ala Arg Ile Arg Leu Gly Lys Ile Gln Tyr Tyr Arg Lys Ala Gln Gly 
            340                 345                 350         


Glu Val Val Pro Leu Ala Asn Ser Arg Phe Trp Gly Ser Asp Gly Gln 
        355                 360                 365             


Ala Glu Ile Lys Arg Ala Glu Ala Phe Val Arg Val Trp Arg His Val 
    370                 375                 380                 


Leu Gly Gln Ala Asn Leu Thr Leu Ala Asn Trp Ala Ser Leu Ala Ser 
385                 390                 395                 400 


Pro Ala Asp Leu Trp Gly Gly Asp Ser Phe Phe Gly His Phe Ser Thr 
                405                 410                 415     


His Ile Asn Gly Lys Leu Phe Ala Thr Asp Ile Gly Leu Asp Ser Arg 
            420                 425                 430         


Arg Thr Val Phe Asp Gln Asn Leu His Leu Leu Phe Gly Asp Ala Ala 
        435                 440                 445             


Gly Leu Phe Gln Ser Asp Asp Glu Thr Arg Lys Ala Ser Ile Leu Leu 
    450                 455                 460                 


Ala His Lys Cys Gly Gly Ala Leu Arg Asn Ala Ala Phe His Phe Lys 
465                 470                 475                 480 


Gly Arg Ala Lys Phe Leu Gln Ala Leu Glu Asn Asp Leu Pro Gln Ala 
                485                 490                 495     


Ala Gln Ser Gly Leu Gln Met Gln Leu Ser Lys Leu Trp Asp Glu Ala 
            500                 505                 510         


Gln Asn Gln Gln Gly Ser Arg Leu Leu Lys Ile Leu Glu Gly Ala His 
        515                 520                 525             


Val Phe His Val Cys Thr Gln Glu Gln Val Gln Gln Leu Val Asn Thr 
    530                 535                 540                 


Leu Gly Asn Val Ser Ala Gly Glu Leu Pro Leu Pro Arg Phe Gly Arg 
545                 550                 555                 560 


Val Ile Glu Arg Asn His His Ala Arg Leu Gly Thr Asn Leu Pro Val 
                565                 570                 575     


Arg Gly Asn Arg Gln Ala Met Glu Gln His Pro Ala Arg Lys Cys Gln 
            580                 585                 590         


Tyr Val Met Leu Lys Leu Leu Tyr Glu Arg Ala Phe Arg Val Trp Leu 
        595                 600                 605             


Glu Asn Thr Thr Asp Glu Val Phe Ser Val Trp Leu Glu Thr Ala Leu 
    610                 615                 620                 


Glu Arg Thr Thr Asn Ala Ala Arg Asn Asn Pro Asn Val Gln Gly Lys 
625                 630                 635                 640 


Ser Gln His Glu Arg Glu Leu Val Met Ala Arg Ala Ala Lys Leu Pro 
                645                 650                 655     


Ile Ser Met Arg Ser Lys Gly Gly Lys Gly Lys Glu Lys Ser Ile Arg 
            660                 665                 670         


Gln Phe Phe Tyr Asp Leu Ser Ala Ala Thr Ala Ser Glu Met Arg Val 
        675                 680                 685             


Gln Arg Gly Tyr Ala Ser Asp Ala Gly Lys Ala Arg Glu Gln Ala Glu 
    690                 695                 700                 


Tyr Ile Asp Glu Leu Leu Arg Asp Val Val Ala Leu Ala Phe Arg Glu 
705                 710                 715                 720 


Phe Ile Arg Ala Asn Gly Phe Asp Trp Leu Leu Asp Ile Asp Pro Gln 
                725                 730                 735     


Gln Glu Leu Arg Glu Thr Arg Cys Cys Leu Met Glu His Ile Arg Phe 
            740                 745                 750         


Pro Ala Ile Ala Pro Arg Ser Asn Ala Trp Gln Pro Val Leu Tyr Phe 
        755                 760                 765             


Leu Leu His Leu Met Pro Val Gly Glu Val Ser Gln Leu Leu His Gln 
    770                 775                 780                 


Leu Ala Lys Trp Glu Ile Leu Ala Lys Pro Glu Gln Ala Arg Thr Asp 
785                 790                 795                 800 


Glu Glu Gly Met Arg Leu His Ala Leu Gln Gln Thr Leu Lys Leu Tyr 
                805                 810                 815     


Leu Asp Met His Asp Ser His Tyr Thr Gly Ala Glu Ser Met Pro Ala 
            820                 825                 830         


Val Glu Arg Ala Val Leu Asp Thr Phe Ala Thr Phe Tyr Glu Thr Arg 
        835                 840                 845             


Asn Gly Leu Asp Lys Val Phe Glu Asp Gln Gly Asn Gly Arg Asp Gly 
    850                 855                 860                 


Ala Arg Tyr Leu Pro Gln Arg Gly Leu Arg Glu Ile Arg Arg Phe Gly 
865                 870                 875                 880 


His Val Pro Val Leu Gln Ala Leu Val Lys Asp Lys Ile Thr Ala Gln 
                885                 890                 895     


Asp Val Thr His Cys Leu Gln Gln Glu Thr Val Pro Ala Asn Gly Lys 
            900                 905                 910         


Leu Ser Pro Val Ala Gln Ala Gln Gln Arg Arg Glu Thr Leu His Gly 
        915                 920                 925             


Glu Trp Val Lys Glu Arg Lys Gln Phe Lys Ala Tyr Arg Asp Tyr Ala 
    930                 935                 940                 


Ala Ala Leu Gln Thr Val Val Val His Arg Gln Leu Ser Asn His Ile 
945                 950                 955                 960 


Arg Leu Val Asp His Val Ala Ala His Arg Ile Val Met Lys Val Leu 
                965                 970                 975     


Ala Arg Leu Ala Asp Phe Ser Gly Leu Phe Glu Arg Asp Leu Thr Phe 
            980                 985                 990         


Val Thr Leu Ala Ala Leu His Glu  His Gln Leu Gln Pro  Glu Asp Phe 
        995                 1000                 1005             


Phe Val  Ile Asp Asn Pro Pro  Arg Tyr Asn Asn Arg  Gly Glu Leu 
    1010                 1015                 1020             


Glu Lys  Asp Gly Leu Thr Leu  Phe Lys Asn Gly Gln  Val Ile Glu 
    1025                 1030                 1035             


Ala Leu  Gly Lys Val Gln Ala  Cys Arg Asp Ala Leu  Lys His Gln 
    1040                 1045                 1050             


Ile Val  Gly Gln Val Asn Leu  Asp Val His Arg Ser  Val Arg Asn 
    1055                 1060                 1065             


Asp Phe  Ala His Phe Asn Met  Leu Tyr Gly Lys Gln  Arg Thr Thr 
    1070                 1075                 1080             


Glu Ser  Ala Thr Asn Arg Val  Ile Lys Cys Pro Ala  Ala Gln Gly 
    1085                 1090                 1095             


Leu Asn  Leu Thr Cys Trp Val  Asn Cys Ala Arg Asn  Leu Met Ser 
    1100                 1105                 1110             


Tyr Asp  Arg Lys Leu Lys Asn  Ala Val Ser Gln Ser  Ile Ile Glu 
    1115                 1120                 1125             


Leu Met  Glu Arg Glu Gly Phe  Ile Leu Thr Trp Glu  Met Asp Thr 
    1130                 1135                 1140             


Asn His  Gln Leu Cys Ser Pro  Lys Leu Gln Ser Arg  Gln Val Glu 
    1145                 1150                 1155             


His Leu  Gly Gly Gln Arg Phe  Pro Leu Val Lys Asp  Glu Arg Lys 
    1160                 1165                 1170             


Lys Leu  Thr Ile Arg Glu Asn  Leu His Ser Val Gly  Met Val Lys 
    1175                 1180                 1185             


Leu Leu  Ala His Ala Phe Gly  Ala Val Ala Glu Asp  Val Lys Asp 
    1190                 1195                 1200             


Ile Ser  Thr Leu Asp Leu Asn  Thr Val Lys Trp Val  Lys Lys Asp 
    1205                 1210                 1215             


Ala Thr  Leu 
    1220     


<210>  316
<211>  1330
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  316

Met Lys Arg Glu Lys Asn Ile Thr Ile Met Lys Ile Ser Lys Val Asn 
1               5                   10                  15      


His Arg Arg Thr Ala Val Ala Leu Asn Gly Asp Lys Ser Glu Leu Gly 
            20                  25                  30          


Gly Ile Leu Tyr Glu Ala Pro Val Gln Lys Asp Lys Asn Gly Asn Tyr 
        35                  40                  45              


Asn Asp Val Ile Ala Glu Thr Gly Lys Val Val Asn Glu Ala Leu Asp 
    50                  55                  60                  


Lys Lys Ser Arg Leu Tyr Thr Pro Phe Asn Asn Gln Lys Val Ile Ile 
65                  70                  75                  80  


Asp Lys Asn Leu Gln Arg Tyr Ala Asn Asn Leu Lys Arg Cys Tyr Ile 
                85                  90                  95      


Asn Phe Val Lys Gln Tyr Val Asn Asn Lys Ser Phe Asn Tyr Lys Ala 
            100                 105                 110         


Met Gln Phe Ile Pro Asp Ile Gln Asn Pro Lys Thr Asn Asp Ala Val 
        115                 120                 125             


Asn Tyr Arg Thr Asp Arg Asp Asn Val Tyr Asn Lys Asn Lys Tyr Tyr 
    130                 135                 140                 


Asp Lys Gln Thr Lys Ser Lys Ser Lys Lys Phe Ile Tyr Glu Lys Ile 
145                 150                 155                 160 


Val Ile Pro Gln Asn Glu Gln Asn Ile Val Ile Ser Ala Leu Val Asn 
                165                 170                 175     


Cys Ser Leu Arg Lys Ser Leu Arg Lys Asp Val Ser Tyr Lys Thr Lys 
            180                 185                 190         


Ser Gly Glu Ile Lys Thr Tyr Asn Leu Pro Glu Leu Val Lys Lys Ser 
        195                 200                 205             


Met Arg Phe Tyr Cys Leu Glu Gly Gln Arg Glu Pro Asp Glu Lys Glu 
    210                 215                 220                 


Lys Tyr Glu Met Tyr Ile Leu Phe Ser Tyr Met Lys Glu Asp Lys Arg 
225                 230                 235                 240 


Thr Lys Asn Thr Asp Leu Leu Val Lys Ser Ile Ser Asn Gln Asn Thr 
                245                 250                 255     


Lys Val Lys Val Glu Asp Ile Asp Gly Asn Lys Leu Leu Lys Leu Ser 
            260                 265                 270         


Ile Ala Asp Thr Lys Lys Lys Pro Leu Trp Glu Tyr Leu Ile Lys Tyr 
        275                 280                 285             


Ala Asp Ser Ser Arg Gln Arg Glu Leu Met Tyr Asp Ile Arg Lys Lys 
    290                 295                 300                 


Ile Ile Leu Tyr Val Ala Gly Ile Glu Glu Tyr Glu Asn Ile Lys Glu 
305                 310                 315                 320 


Asp Ser Gly Leu Ser Lys Val Ser Trp Ser Lys Tyr Asn Ile Ser Asp 
                325                 330                 335     


Asn Lys Met Phe Phe Asp Ile Asn Ser Cys Thr Asp Lys Arg Lys Gln 
            340                 345                 350         


Asn Leu Glu Ile Lys Ile Arg Glu Ala Asn Ile Glu His Tyr Arg Asn 
        355                 360                 365             


Ala Ser Ser Lys Leu Cys Asp Asp Glu Ser Ile Phe Trp Phe Gln His 
    370                 375                 380                 


Phe Glu Gly Val Ile Glu Thr Leu Phe Ser Lys Lys Ser Lys Ile Ser 
385                 390                 395                 400 


Glu Glu Arg Leu Gly Cys Ala Tyr Ile Cys Asp Tyr Leu Trp Lys Asp 
                405                 410                 415     


Phe Leu Ser Tyr Leu Ala Ala Lys Tyr Ile Asp Leu Gly Lys Gly Val 
            420                 425                 430         


Tyr His Phe Thr Met Lys Asp Lys Leu Asp Met Leu Asn Lys Asn Glu 
        435                 440                 445             


Ala Val Thr Asp Leu Arg Phe Gly Ile Val Ser Glu Lys Tyr Glu Lys 
    450                 455                 460                 


Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Glu Leu 
465                 470                 475                 480 


Asp Arg Asn Ile Ala Ala Tyr Val Thr Phe Ala Ala Asp Ile Phe Ala 
                485                 490                 495     


Lys Ser Val Ile Lys Ser Asp Tyr Arg Thr Lys Lys Asp Asn Asn Ser 
            500                 505                 510         


Asp Val Leu Gln Tyr Ser Asp Lys Glu Phe Arg Asn Ser Glu Val Ile 
        515                 520                 525             


Arg Asp Asn Ala Glu Lys Asn Ile Leu Gln Tyr Trp Gly Gly Tyr Ser 
    530                 535                 540                 


Arg Trp Cys Thr Glu Asn Ser Lys Leu Pro Glu Asn Asn Lys Val Ser 
545                 550                 555                 560 


Asp Phe Gly Lys Leu Asp Val Ser Asp Leu Cys Ile Asp Ile Lys Lys 
                565                 570                 575     


His Leu Ala Gly Ile Arg Asn Ser Ser Val His Tyr Thr Thr Lys Ile 
            580                 585                 590         


Lys Asn Glu Ser Ala Ala Asp Gly Ser Asn Val Lys Ile Leu Phe Glu 
        595                 600                 605             


Lys Asp Leu Ala Asp Ile Asn Ile Ile Tyr Ala Asp Lys Tyr Tyr Ser 
    610                 615                 620                 


Asn Asn Val Trp Met Phe Tyr Ser Leu Glu Asp Ile Asn Lys Leu Ile 
625                 630                 635                 640 


Ala Phe Leu Tyr Lys Glu Lys Arg Val Ile Arg Gln Val Gln Ile Pro 
                645                 650                 655     


Ser Phe Ser Arg Ile Leu Lys Arg Lys Ala Met Gln Asp Val Ile Asn 
            660                 665                 670         


Glu Ile Phe Lys Asp Asp Phe Asp Glu Asn Ile Val Asn Pro Glu Leu 
        675                 680                 685             


Lys Glu Lys Tyr Arg Asn Ser Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
    690                 695                 700                 


Tyr Asn Ala Phe Ile Ile Gln Pro Glu Leu Lys Glu Lys Phe Lys Asp 
705                 710                 715                 720 


Lys Ile Lys Thr Met Lys Ser Glu Leu Tyr Asn Lys Leu Lys Thr Ile 
                725                 730                 735     


Asp Lys Lys Glu Tyr Lys Ala Leu Tyr Cys Met Leu Ser Asn Glu Glu 
            740                 745                 750         


Ser Ala Leu Lys Asn Phe Ala Asp Arg Ile Tyr Ser Val Asp Gly Asp 
        755                 760                 765             


Asn Val Ser Phe Ala Asp Ile Cys Lys Ile Leu Met Thr Asp Tyr Asn 
    770                 775                 780                 


Met Gln Asn Gln Glu Lys Lys Asn Ile Glu Ser Met Glu Gln Lys Lys 
785                 790                 795                 800 


Lys Asn Lys Gly Lys Asp Glu Asn Tyr Lys His Phe Pro Leu Leu Leu 
                805                 810                 815     


His Lys Val Leu Lys Glu Leu Phe Ile Glu Tyr Leu Lys Gln Thr His 
            820                 825                 830         


Glu Leu Glu Phe Leu Arg Asn Asn Ile Cys Ile Lys Ser Asp Val Thr 
        835                 840                 845             


Met Glu Ser Phe Glu Ser Gln Ile Lys Gly Val Glu Ile Tyr Lys Asp 
    850                 855                 860                 


Leu Lys Glu Lys Ile Asp Lys Asn Asn Ser Leu Leu Asp Trp Tyr Val 
865                 870                 875                 880 


Ile Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asn 
                885                 890                 895     


Ile Lys Asn Tyr Ile Gln Phe Ala Thr Asn Ile Asp Lys Arg Ala Glu 
            900                 905                 910         


Ser Val Lys Asn Leu Thr Glu Ser Gly Met Val Lys Arg Ile Gln Tyr 
        915                 920                 925             


Tyr Asp Asp Ile Val Arg Thr Leu Glu Phe Ser Ala Gln Tyr Ile Gly 
    930                 935                 940                 


Lys Ile Ser Asn Asn Ile Asn Asp Tyr Phe Asn Ser Glu Asp Glu Tyr 
945                 950                 955                 960 


Val Ser Phe Leu Ser Lys Tyr Val Gly Phe Ile Asn Asp Lys Ser Glu 
                965                 970                 975     


Asp Val Leu Thr Glu Leu Lys Asp Phe Cys Arg Glu Lys Ile Asn Asn 
            980                 985                 990         


Gly Ser Gln Ile Ile Gly Ile Tyr  Tyr Gly Gly Asp Asn  Val Ile Ile 
        995                 1000                 1005             


Asn Arg  Asn Val Ile Tyr Ala  Gln Met Tyr Ser Asn  Ala Glu Val 
    1010                 1015                 1020             


Phe Ser  Asn Ile Tyr Lys Lys  Val Thr Lys Asn Asp  Ile Ile Asn 
    1025                 1030                 1035             


Tyr Tyr  Glu Lys Gln Asn Asp  Leu Lys Asp Val Phe  Lys Ser Gly 
    1040                 1045                 1050             


Val Cys  Gln Asn Glu Asp Glu  Gln Arg Ser Leu Cys  Glu Phe Gln 
    1055                 1060                 1065             


Gln Leu  Lys Asn Arg Ile Glu  Leu Thr Glu Leu Ser  Thr Tyr Ala 
    1070                 1075                 1080             


Asp Met  Val Asn Asp Phe Met  Ala Gln Phe Val Glu  Trp Ala Tyr 
    1085                 1090                 1095             


Leu Arg  Glu Arg Asp Leu Met  Tyr Phe Gln Leu Gly  Ile His Tyr 
    1100                 1105                 1110             


Ile Arg  Leu Phe Tyr Ser Asp  Asn Val Leu Asp Glu  Lys Tyr His 
    1115                 1120                 1125             


Lys Leu  Ser Asp Asn Val Ile  Asp Ile Glu Glu Gly  Ala Leu Leu 
    1130                 1135                 1140             


Tyr Gln  Ile Val Ala Met Tyr  Asp Tyr Glu Leu Arg  Ile Phe Glu 
    1145                 1150                 1155             


Thr Asp  Asn Ser Gly Asn Ala  Lys Arg Ile Gly Gln  Gly Gly Pro 
    1160                 1165                 1170             


Gly Lys  Ser Ile Pro Val Phe  Leu Lys Lys Tyr Cys  Ser Gly Thr 
    1175                 1180                 1185             


Asp Val  Tyr Glu Cys Gly Leu  Glu Leu Phe Glu Asp  Ile Asn Gln 
    1190                 1195                 1200             


His Glu  His Ile Ile Arg Phe  Arg Asn Asp Ile Ala  His Met Arg 
    1205                 1210                 1215             


Tyr Met  Ser Asn Gln Ala Met  Asn Ile Met Ser Ile  Val Ser Asn 
    1220                 1225                 1230             


Ile Tyr  Lys Ser Phe Phe Ala  Tyr Asp Thr Lys Leu  Lys Lys Ser 
    1235                 1240                 1245             


Ile Ser  Leu Val Phe Lys Asn  Ile Leu Met Arg Tyr  Gly Val Ile 
    1250                 1255                 1260             


Ala Asp  Leu Val Phe Ser Tyr  Asn Asn Lys Asn Gln  Ser Ile Lys 
    1265                 1270                 1275             


Asp Asp  Met Asp Ile Asn Ile  Ile Asn Ile Lys Asn  Leu Lys Ser 
    1280                 1285                 1290             


Asp Lys  Tyr Val Tyr Lys Ile  Val Asn Glu Asp Ile  Val Lys Gln 
    1295                 1300                 1305             


Val Glu  Ile Glu Ile Arg Asn  Gln Val Phe Leu Glu  Gln Leu His 
    1310                 1315                 1320             


Asn Leu  Leu Tyr Phe Ser Arg  
    1325                 1330 


<210>  317
<211>  1372
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  317

Met Lys Leu Ser Lys Glu Lys Gln Ile Arg Ser Ala Val Ala Asn Lys 
1               5                   10                  15      


Glu Lys Asn Thr Glu Gly Val Leu Tyr Arg Phe Pro Gly Asp Asp Ile 
            20                  25                  30          


Gly Gly Val Gln Ala Gln Met Leu Val Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Leu Gly Asn Lys Pro Lys Glu 
    50                  55                  60                  


Trp Met Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Lys Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Ala Ile Asn Asp Ile Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Lys Glu Ala Asp Lys Lys Ile Arg Asn Met Ser Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Asn Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Ser Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Gly Asn Gln Glu Phe Asp Ser Ile Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Asp Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Ser Ile Gln Asp Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Ile Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Glu Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Asp Gly Leu Asn Glu Phe Met Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Glu Glu Lys Arg Ala Glu Val Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Ser His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Val Asn Lys Gly Lys Phe Tyr Val Trp 
305                 310                 315                 320 


Lys Lys His Glu Cys Gly Lys Lys Glu Asn Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Val Glu Ala Glu Ala Glu Ser Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Ile Phe Phe Glu Asn Asp Thr Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Thr Gly Thr Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Lys Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asn Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Gln Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Leu 
            660                 665                 670         


Val Arg Thr Val Phe Pro Glu Tyr Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Asn Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Arg Thr Leu Arg Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Lys 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Glu Asn Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Cys Ala Gln Asp 
            900                 905                 910         


Ile Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu 
        915                 920                 925             


Leu Ser Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Lys Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Lys Phe Ser Glu Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Thr Asn Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Gly  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Glu Lys Pro Glu  Glu Tyr Glu Lys Ile  Glu Ala Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Ile  Tyr Ala Pro Glu Lys  Asn Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Gln Gly Arg Val Gly  Ala Lys Val 
    1145                 1150                 1155             


Thr Ser  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Glu Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Met Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Val Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Val Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Glu Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asn Ala 
    1280                 1285                 1290             


Lys Asp  Lys Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Asp  Ala Glu Asp Ala Asp  Ser Lys Lys Pro Val  Ile Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Glu  Asp Glu Asp 
    1325                 1330                 1335             


Lys Gln  Lys Gly Lys Glu Asn  Arg Gly Lys Lys Asn  Thr Glu Thr 
    1340                 1345                 1350             


Arg Ser  Asp Ala Glu Lys Asn  Asn Asn Glu Arg Leu  Ser Tyr Asn 
    1355                 1360                 1365             


Pro Phe  Ala Asn 
    1370         


<210>  318
<211>  1287
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  318

Met Arg Ile Gly Lys Val Gln Gly Arg Thr Phe Thr Gly Phe Asp Asn 
1               5                   10                  15      


Ala Arg Gly Lys Thr Leu Arg Arg Arg Leu Leu Thr Arg Pro Asp Asn 
            20                  25                  30          


Glu Ala Arg Ser Leu Ser Glu His Leu Ala His Asp Pro Lys Ala Leu 
        35                  40                  45              


Ile Gly Gln Ala Ile Ser Arg Ile Asp Thr Ile Tyr Gln Lys Pro Lys 
    50                  55                  60                  


Thr Gly Lys Pro Thr Pro Glu Gln Phe Gly His Arg Asp Thr Leu Gly 
65                  70                  75                  80  


Trp Ala Tyr Trp Lys Leu Leu Val Ala Ser Tyr Pro Glu Val Glu Gly 
                85                  90                  95      


His Arg Asp Leu Phe Val Arg Arg Leu His Pro Tyr Gly Asp Thr Pro 
            100                 105                 110         


Pro Lys Ser His Gly Gln Lys Glu Gly Glu His Gln Lys Gly Gly Lys 
        115                 120                 125             


Pro Gln Leu Glu Gly Arg Trp His Gly Val Met Ala Gln His Gly Lys 
    130                 135                 140                 


Asn Pro Asp Gln Ile Ala Ala Arg Leu Phe Asp His Leu His Asn Ser 
145                 150                 155                 160 


Glu Leu Arg Phe Gly Gly Thr Ala Ser Gly Glu Pro Arg Thr Arg Pro 
                165                 170                 175     


Gly Lys Glu Ala Thr Pro Thr Gly Leu Ile Gly Ala Arg Ala Lys Thr 
            180                 185                 190         


Ile Glu His Ser Val Leu Pro Arg Asp Ala Lys Arg Phe Val Ala Glu 
        195                 200                 205             


Trp Arg Gly Glu Asp Gln Glu Arg Tyr Ala Gly Ala Arg Asp Ile Ala 
    210                 215                 220                 


Ala Ala Ile Ser Ala Gly Leu Asn Asp Lys Asp Gln Lys Ser Gly Ser 
225                 230                 235                 240 


Gly Arg Lys Ser Ala Val Ile Gly Lys Leu Leu Ser Asp His Leu Glu 
                245                 250                 255     


Thr Leu Thr Gly Asn Arg Lys Cys Arg Phe Asp Pro Lys Ser Thr Ala 
            260                 265                 270         


Glu Thr Leu Glu Leu Arg Asp Gly Glu Ser Val Asp Asp Arg Arg Arg 
        275                 280                 285             


Ile Leu Glu Leu His Ala Glu Val Lys Ala Thr Tyr Lys Arg Met Ala 
    290                 295                 300                 


Ala Trp Lys Pro Ala Lys Leu Pro Arg Asn Ser Asp Glu Leu Phe Arg 
305                 310                 315                 320 


Leu Val Arg Gln Gln Ala Asp Asn Arg Ile Leu Asn His Leu Val Arg 
                325                 330                 335     


Val Gly Arg Ile Ser Val Tyr Ser Glu Gln Ser Asp Ala Leu Ser Glu 
            340                 345                 350         


Ser Gln Phe Trp Thr Ser Gly Gly Gln Thr Gln Ile Lys Glu Ser Glu 
        355                 360                 365             


Val Phe Ala Arg Leu Trp Ile Gly Ala Ile Ser Arg Ala Ser Tyr Ser 
    370                 375                 380                 


Met Lys Ala Trp Leu Glu Pro Glu Gly Thr Val Phe Asn Pro Ser Ile 
385                 390                 395                 400 


Asn Asp Phe Asp Val Thr Ser Ser His Asn Thr Asn Arg Ile Leu Glu 
                405                 410                 415     


Asp Ser Gly Arg Leu Ser Asn Ala Met Ala Arg Arg Ala Ile Tyr Phe 
            420                 425                 430         


Gly Glu Thr Pro Glu Phe Asp Ala Leu Gly Glu Glu Asp Gln Arg Val 
        435                 440                 445             


Leu Val Lys Lys Cys Leu Asp Ala Leu Ser Ala Cys Arg Asn Arg Thr 
    450                 455                 460                 


Phe His His Gly Gln Arg Ala Lys Phe Leu Lys Glu Val Arg Lys Gly 
465                 470                 475                 480 


Leu Lys Glu Lys Glu Ala Asp Ser Ala Gly Pro Ala Ala Trp Glu Gly 
                485                 490                 495     


Ile Arg Glu Val Ile Gln Ala Asp Ala Arg Asn Leu Gly Ala Arg Leu 
            500                 505                 510         


Leu Gln Asp Leu Thr Gly Ala Lys Val His Ser Phe Ala Thr Asp Pro 
        515                 520                 525             


Glu Phe Arg His Leu Tyr Glu Ser Val Ala Ala Thr Leu Thr Ala Gly 
    530                 535                 540                 


Gly Glu Leu Glu Ala Ala Leu Pro Arg Leu Lys Asn Val Leu Lys Arg 
545                 550                 555                 560 


Ala Glu Gly Val Arg Cys Tyr Leu Asp Thr Pro Ser Gln Arg Arg Glu 
                565                 570                 575     


Gly Asp Glu Ser Leu Ile Ala Arg Leu Pro Val Ala Pro Val Pro Arg 
            580                 585                 590         


Glu Leu Asp Asp Ala Ala Thr Lys Ala Arg His Ser Ala Leu Leu Arg 
        595                 600                 605             


Leu Tyr Asp Gly Pro Phe Arg Pro Trp Ala Thr Glu Leu Arg Gly Glu 
    610                 615                 620                 


Arg Leu Ser Asp Tyr Ala Ala Arg Ala Lys Arg Leu Ala Thr Arg Leu 
625                 630                 635                 640 


Ala Lys Ser Thr Asn Thr Ala Ser Pro Tyr Pro Asp Ser Val Glu Gly 
                645                 650                 655     


Arg Ser Val Arg Leu Arg Asp Pro Ile Thr Ala Asp Thr Ala Pro Glu 
            660                 665                 670         


Thr Leu Lys Thr Tyr Leu Ser Ala Leu Thr Ala Glu Thr Ala Thr Glu 
        675                 680                 685             


Phe Arg Val Gln Lys Gly Tyr Glu Ser Asp Gly Glu Lys Ala Lys Glu 
    690                 695                 700                 


Gln Ala Glu Phe Ile Glu Asp Phe Arg Arg Asp Met Ile Ala Leu Ala 
705                 710                 715                 720 


Phe Gln Asp Phe Ile Arg Asp His Gly Phe Ala Trp Leu Leu Asp Ile 
                725                 730                 735     


Ala Ser Lys Ala Glu Pro Ser Asn Asp Ala Pro Asn Leu Pro Asp Pro 
            740                 745                 750         


Val Asp Thr Gly Lys Asp Thr Val Phe Glu Asp Trp Gln Ala Leu Leu 
        755                 760                 765             


Tyr Leu Phe Leu His Phe Val Pro Ala Asp Asp Val Ser Gln Leu Leu 
    770                 775                 780                 


His Gln Leu Arg Lys Trp Asp Ala Leu Gln Asp Lys Tyr Glu Leu Ala 
785                 790                 795                 800 


Glu Pro Gly Glu Thr Leu Gly Gln Thr Lys Ala Asp Thr Arg Lys Ile 
                805                 810                 815     


Val Gly Gln Phe Arg Asp Cys Leu Thr Leu Phe Leu Lys Thr Gly Asp 
            820                 825                 830         


Ala Arg Phe Asp Gly Glu Gly Val Glu Leu Pro Leu Ser Asp Phe Gln 
        835                 840                 845             


Glu Leu Phe Glu Ser Pro Ala Thr Phe Lys Glu Leu Phe Leu Ala Glu 
    850                 855                 860                 


Pro Ala Glu Asn Asp Ala Ser Glu Thr Asp Asp Gln Asp Ala Pro Gly 
865                 870                 875                 880 


Glu Lys His Arg Val Thr Arg Thr Arg Arg Gly Leu Arg Gln Ile Leu 
                885                 890                 895     


Arg Tyr Asn His Met Pro Val Leu Arg Asp Leu Phe Leu Ala His Lys 
            900                 905                 910         


Val Thr Asp Ala Glu Val Asp Gly Leu Gln Ala Leu Glu Val Asp Asp 
        915                 920                 925             


Pro Gln Thr Gly Glu Ser Gln Ile Gly Ala Ala Gln Arg Ile Arg Thr 
    930                 935                 940                 


Glu Ile His His His Thr Ser Asn Asp Lys Gln Ile Ser Glu Ala Lys 
945                 950                 955                 960 


Val Glu Glu Tyr Arg Arg Ala Leu Ser Thr Ile Glu Arg His Arg Phe 
                965                 970                 975     


Leu Val Gly Arg Val Tyr Leu Gly Asp His Ile Arg Val His Lys Leu 
            980                 985                 990         


Met Met Asp Val Met Gly Arg Leu  Val Asp Phe Ala Gly  Ala Trp Glu 
        995                 1000                 1005             


Arg Glu  Ala Ala Asp Gly Asp  Arg Lys Gly Phe Ile  Ser Arg Ala 
    1010                 1015                 1020             


Ile Ala  Leu Pro Glu Val Ala  Glu Gly Tyr Ala Ala  Asp Arg Leu 
    1025                 1030                 1035             


Lys Thr  Val Ala Arg Arg Val  Leu Asp Asp Gly Glu  Ala Arg Arg 
    1040                 1045                 1050             


Ile Arg  Asn Asp Leu Gly His  Phe Asn Asp Leu Ala  Pro Thr Ser 
    1055                 1060                 1065             


Gly Pro  Ala Asn Leu Thr Phe  Val Val Asn Arg Ala  Arg Arg Met 
    1070                 1075                 1080             


Met Arg  His Asp Arg Lys Arg  Lys Asn Ala Val Thr  Lys Ser Val 
    1085                 1090                 1095             


Ile Glu  Ile Leu Asn Arg Gln  Gly Leu Gly Ile Glu  Trp Thr Met 
    1100                 1105                 1110             


Arg Asn  His Glu Leu Cys Glu  Ala Lys Leu Trp Gln  Asn Pro Val 
    1115                 1120                 1125             


Lys His  Leu Gly Phe Ala Thr  Leu Glu Gly Arg Gly  Lys Lys Trp 
    1130                 1135                 1140             


Arg Arg  Pro Phe Glu Ala Arg  Tyr Gly Asp Ala Tyr  Met Ala Met 
    1145                 1150                 1155             


Val Ala  Gln Leu Phe Asp Gly  Thr Val Thr Ser Pro  Pro Ala Lys 
    1160                 1165                 1170             


Gly Pro  Pro Gln Ser Gly Lys  Ser Gly Gly Lys Pro  Gly Lys Gly 
    1175                 1180                 1185             


Ala Glu  Gly Gly Ala Lys Glu  Lys Ser Arg Ser Pro  Thr Arg Met 
    1190                 1195                 1200             


Glu Glu  Gly Gly Val Tyr Glu  Gly Arg Val Ala Lys  Ala Lys Ser 
    1205                 1210                 1215             


Asp Lys  Gly Phe Gly Phe Leu  Leu Val Glu Gly Ala  Gln Glu Glu 
    1220                 1225                 1230             


Ile Phe  Leu His Ile Tyr Gly  Ile Ser Gly Asn Arg  Pro Ala Arg 
    1235                 1240                 1245             


Ile Glu  Asn Gly Gln Arg Tyr  Arg Phe Thr Leu Gly  Ile Asp Arg 
    1250                 1255                 1260             


Asp Arg  Glu Arg Arg Lys Glu  Arg Ala Trp Val Ala  Arg Glu Ala 
    1265                 1270                 1275             


Val Arg  Ile Asp Glu Asn Arg  Ser Lys 
    1280                 1285         


<210>  319
<211>  1373
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  319

Met Ala Lys His Leu Arg Pro Ile Gly Glu Ser Tyr Thr Asp Phe Leu 
1               5                   10                  15      


Asp Glu Thr Glu Phe Val Arg Leu Gly Arg Gly Leu His Arg Gly His 
            20                  25                  30          


His Gly Val Gln Ile Pro Pro Thr Glu Leu Pro Ser Tyr Leu Ala Glu 
        35                  40                  45              


Tyr Arg Lys Ala Leu Met Arg Gln Val Val Ala Val Leu Asp Lys Val 
    50                  55                  60                  


Val Gly Lys Arg Arg Arg Leu Ser Gly Met His Pro Glu Ala Tyr Arg 
65                  70                  75                  80  


Asp Arg Val His Leu Ala Glu Ala Leu Trp Val Arg Leu Val Ala Arg 
                85                  90                  95      


Val Lys Glu Ile Gly Thr Pro Pro Asp Pro Ser Glu Leu Leu Asp Leu 
            100                 105                 110         


Arg Arg Met Trp Asn Ala Lys Ala His Pro Tyr Ala Glu Tyr Asp Val 
        115                 120                 125             


Val Pro Arg Ala Pro Leu Asn Asp Gly Asn Gly Gln Lys Ile Leu Glu 
    130                 135                 140                 


Cys Arg Glu Val Asp Asp Pro Lys Ile Glu Arg Ser Asp Phe Glu Gly 
145                 150                 155                 160 


Arg Trp His Gly Arg Phe Trp Gln Ser Glu Pro Gly Pro Val Asp Tyr 
                165                 170                 175     


Asn Ala Ile Ala Asp Arg Ile Phe Ala His Leu Phe Asp Gln Glu Ala 
            180                 185                 190         


Val Ile Gly Gly Gly Pro Arg Arg Glu Gly Asn Val Thr Val Pro Asp 
        195                 200                 205             


Glu Asp Ile Asn Gly Gln Pro Gly Pro Ala Thr Gly Lys Gly Leu Ile 
    210                 215                 220                 


Ile Ala Arg Gly Gln Ser Ile Val Lys Ser Ala Ser Asp Pro Arg Arg 
225                 230                 235                 240 


Ser Ser Lys Lys Val Gln Arg Thr Trp Asp Lys Ala Val Glu Arg Arg 
                245                 250                 255     


Tyr Phe Gly Asp Asp Gly Lys Gly Gly Ser Asp Ile Ala Lys Ala Ile 
            260                 265                 270         


Tyr Glu Glu Leu Gly Asp Pro Ala Thr Leu Ala Asp Pro Ile Tyr Ala 
        275                 280                 285             


Ser Trp Phe Gly Ser Arg Leu Tyr Asp His Phe Gly Ser Phe Lys Asn 
    290                 295                 300                 


Ser Leu Pro Leu Glu Leu Lys Asp Pro Phe Lys Glu Gln Ile Trp Ala 
305                 310                 315                 320 


Leu His Asn Ser Val Arg Gln Phe Tyr Gln Arg Met Ala Lys Ser Asp 
                325                 330                 335     


Arg Phe Arg Leu Ala Leu Gln Asn Ala Arg Ser Glu Val Pro Asp Arg 
            340                 345                 350         


Ser Glu Leu Leu Ala Leu Leu Pro Lys Asp His Asp His Leu Leu Leu 
        355                 360                 365             


Val Leu Gly Gly Lys Lys Lys Asn Ala Glu Met Ser Glu Leu Ile Arg 
    370                 375                 380                 


Leu Gly Lys Leu Phe Val His Ala Ser Asp Val Leu His Asp Phe Asp 
385                 390                 395                 400 


Ala Asn Asp Ala Ala Ala Leu Asp Ala Phe Lys Arg Arg Met Ser Phe 
                405                 410                 415     


Leu Ala Thr Ser Ile Gly Gln Ser Glu Ile Lys Gln Thr Glu Thr Phe 
            420                 425                 430         


Ala Arg Thr Trp Arg Gly Ala Val Gly Leu Thr Leu Arg Thr Val Lys 
        435                 440                 445             


Gly Leu Ala Asp Pro Arg Gly Ile Ile Gly Thr Pro Asp Asn Arg Asp 
    450                 455                 460                 


Leu Gly Thr Ala Gly Pro Met Lys Asp Ala Phe Asn Lys Phe Asp Gln 
465                 470                 475                 480 


Pro His Phe Gln Gln His Met Thr Ile Ile Phe Gly Asn Lys Glu Leu 
                485                 490                 495     


Gln Ala Glu Gly Asn Pro Thr Arg Ser Ser Val Phe Thr Ala Asn Gly 
            500                 505                 510         


Asp Lys Asp His Gln Ala Glu Leu Leu Trp Gly Phe Leu Cys Val Val 
        515                 520                 525             


Arg Ser Val Arg Asn Arg Thr Asn His Tyr Asn Val Arg Arg Ala Leu 
    530                 535                 540                 


Leu Arg Leu Leu Asp Glu Gly Ile Val Ser Pro Met Pro Ser Asp Pro 
545                 550                 555                 560 


Lys Lys Glu Arg Val Glu Asn Arg Asn Leu Cys Thr Val Ser Pro Thr 
                565                 570                 575     


Ala Leu Glu Ala Phe Arg Arg Leu Leu Asn Phe Asp Leu Ala Ile Gln 
            580                 585                 590         


Lys Glu Ala Val Arg Thr Ala Leu Glu Gln Ala Lys Ala Ser Glu Phe 
        595                 600                 605             


Val Glu Glu Gly Lys Leu Arg Gly Leu Val Ser Glu Leu Ala Gly Thr 
    610                 615                 620                 


Glu Asp Met Pro Ala Leu His Ile Pro Arg Phe Ser Ala Val Met Asp 
625                 630                 635                 640 


Lys Val Arg Arg Leu Ala Asp Asn Arg Asp Val Gly Leu Asp Pro Ile 
                645                 650                 655     


Leu Ser Thr Leu Gln Arg Ser Leu Pro Pro Thr Asp Lys Gln Ala Glu 
            660                 665                 670         


Ser Asp Ala Ala Arg Cys Arg Tyr Arg Leu Leu Leu Glu Leu Tyr Lys 
        675                 680                 685             


Ser Gly Phe Arg Ser Trp Phe Ser Gly Ile Gln Ser Asn Glu Glu Asn 
    690                 695                 700                 


Asn Arg Glu Ile Cys His Trp Ala Val Lys Gln Val Gly Arg Ala Lys 
705                 710                 715                 720 


Asp Ala Arg Lys Ser Glu Tyr Asp Lys Lys Thr Lys Arg His Tyr Arg 
                725                 730                 735     


Ser Pro Asn Ser Leu Ile Asp Asp Leu Gly Leu Asp Lys Phe Asp Asp 
            740                 745                 750         


Leu Thr Asp Leu Leu Glu Ala Leu Ala Ser Gln Ser Thr Arg Glu His 
        755                 760                 765             


Asp Gln Asn Leu Lys Tyr Val Pro Asp Ala Arg Val Gln Ser Gln Met 
    770                 775                 780                 


Ser Asn Arg Ile Glu Glu Phe Arg Gln Glu Leu Phe Ala His Ile Phe 
785                 790                 795                 800 


Thr Lys Tyr Leu Asp Thr His Asp Phe Gly Trp Ile Gly Ala Ile Glu 
                805                 810                 815     


Val Arg Arg Glu Ala Cys Asp Leu Ala Asp Val Val Ser Ala Phe Glu 
            820                 825                 830         


Val Arg Asp Gln Lys Phe Asp Ala Asp Trp His Ser Gln Phe Tyr Ala 
        835                 840                 845             


Trp Leu Tyr Met Val Pro Pro Ile Glu Ala Ser Arg Leu Arg His Gln 
    850                 855                 860                 


Met Arg Lys Ser Ala Val Met Asp Asp Lys Trp Ser Thr Thr Leu Glu 
865                 870                 875                 880 


Leu Thr Ser Gly Asp Arg Lys Thr Arg Asp Asp His Ala Gln Asp Val 
                885                 890                 895     


Leu Ala Asp Met Asp Arg Leu Phe Ser Leu Tyr Thr Lys Val Gln Ala 
            900                 905                 910         


Ala Gly Phe Asn Gly Gln Glu His Glu Ser Ala Leu Gly Ser Lys Ser 
        915                 920                 925             


Leu Phe Tyr Glu Asp Gly Asn Gln Phe Asp Glu Val Tyr Ser Pro Asp 
    930                 935                 940                 


Thr Glu Thr His Asn Lys Thr Phe Pro Gly Thr Arg Arg Gly Leu Arg 
945                 950                 955                 960 


Gln Leu Val Arg Tyr Ala His Leu Pro Ala Leu Glu Gly Val Phe Lys 
                965                 970                 975     


Lys His Arg Ile Thr Lys Ala Glu Val Glu Thr Phe Val Ala Leu Tyr 
            980                 985                 990         


Asp Glu Asn Arg Arg Asp Pro Gly  Ser Val Ala His Met  Leu Arg Arg 
        995                 1000                 1005             


Glu Lys  Leu Arg Thr Glu Ile  Leu Arg Ser Ile His  Asp Gly Pro 
    1010                 1015                 1020             


Lys Pro  Lys Asp Lys Asp Phe  Trp Pro Lys Leu Glu  Ala Lys Cys 
    1025                 1030                 1035             


Leu Glu  Tyr Arg Thr Val Ala  Thr Glu Thr Ala Ile  Tyr Asn Phe 
    1040                 1045                 1050             


Gln Ala  Asn Ala Ala Arg Leu  Asn Asp His Ala Arg  Leu His Gln 
    1055                 1060                 1065             


Ile Val  Met Arg Val Val Ala  Arg Leu Thr Asp Tyr  Ala Leu Ile 
    1070                 1075                 1080             


Trp Glu  Arg Asp Arg Leu Phe  Ala Phe Val Gly Met  Leu Tyr Arg 
    1085                 1090                 1095             


Gln Thr  Gly Gly Thr Gly Ile  Asn Pro Ala Met Arg  His Ala Glu 
    1100                 1105                 1110             


Lys Thr  Asn Ala Pro Pro Arg  Ile Gly Ile Leu Val  Ser Asp Ser 
    1115                 1120                 1125             


Ala Leu  Ala Lys Lys Leu Asn  Ser Asn Ser Ala Glu  Val Phe Ile 
    1130                 1135                 1140             


Pro Tyr  Leu Asp Thr Glu Thr  Gly Phe Asp Ala Pro  Arg Phe Asp 
    1145                 1150                 1155             


Asp Leu  Cys Thr Leu Leu Ser  His Glu His Ala Lys  Glu Phe Arg 
    1160                 1165                 1170             


Phe His  Phe Leu Glu Val Gly  Glu Glu Asn Ser Lys  Asp Glu Ala 
    1175                 1180                 1185             


Arg Arg  Leu Asn Glu Glu Thr  Met Gly His Arg Lys  Arg Pro Ala 
    1190                 1195                 1200             


Phe Lys  Arg Gly Thr Arg Arg  Gln Gly Ile Arg Asn  Asp Leu Ala 
    1205                 1210                 1215             


His His  Asn Val Leu Asp Leu  Ala Gly Gly Ala Gly  Pro Asn Leu 
    1220                 1225                 1230             


Thr Tyr  Val Val Asn Ala Val  Arg Ser Leu Leu Ser  Tyr Asp Arg 
    1235                 1240                 1245             


Lys Leu  Lys Asn Ala Val Pro  Lys Ser Ile Lys Arg  Ile Leu Gly 
    1250                 1255                 1260             


Glu Glu  Gly Leu Ile Ile Glu  Trp Gln Met Asn Tyr  Asp Arg Leu 
    1265                 1270                 1275             


Lys Lys  Pro Thr Val Tyr Pro  Asn Val Glu Thr His  Leu Thr Met 
    1280                 1285                 1290             


Val Pro  Pro Arg His Met Thr  Ala Pro Val Ser Phe  Thr Leu Pro 
    1295                 1300                 1305             


Arg Ala  Ser Val Arg Leu Ala  Ser Met Val Lys Ala  Val Phe Asp 
    1310                 1315                 1320             


Phe Gly  Ser Ser Gly Tyr Gly  Glu Glu Arg Met Ile  Gly Gly Arg 
    1325                 1330                 1335             


Thr Ala  Lys Gln Ala Val Tyr  Pro Asp Asp Phe Thr  Arg Arg Phe 
    1340                 1345                 1350             


Pro Gln  Thr Pro Met Gly Leu  Lys Gln Ala Thr Arg  Leu Val Phe 
    1355                 1360                 1365             


Ala Ser  Glu Asn Ser 
    1370             


<210>  320
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  320

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  321
<211>  1380
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  321

Met Lys Leu Ser Lys Glu Lys Gln Ile Arg Ser Ala Val Ala Asn Lys 
1               5                   10                  15      


Glu Lys Asn Thr Glu Gly Val Leu Tyr Arg Phe Pro Gly Asp Asp Ile 
            20                  25                  30          


Gly Gly Val Gln Ala Gln Met Leu Val Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Leu Gly Asn Lys Pro Lys Glu 
    50                  55                  60                  


Trp Met Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Lys Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Ala Ile Asn Asp Ile Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Lys Glu Ala Asp Lys Lys Ile Arg Asn Met Ser Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Asn Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Ser Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Gly Asn Gln Glu Phe Asp Ser Ile Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Asp Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Ser Ile Gln Asp Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Ile Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Glu Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Asp Gly Leu Asn Glu Phe Met Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Glu Glu Lys Arg Ala Glu Val Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Ile His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Val Asn Lys Gly Lys Phe Tyr Val Trp 
305                 310                 315                 320 


Lys Lys His Glu Cys Gly Lys Lys Glu Asn Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Val Glu Ala Glu Ala Glu Ser Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Ile Phe Phe Glu Asn Asp Thr Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Thr Gly Thr Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Lys Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asn Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Gln Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Leu 
            660                 665                 670         


Val Arg Thr Val Phe Pro Glu Tyr Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Asn Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Arg Thr Leu Arg Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Lys 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Glu Asn Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Cys Ala Gln Asp 
            900                 905                 910         


Ile Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu 
        915                 920                 925             


Leu Ser Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Lys Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Lys Phe Ser Glu Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Thr Asn Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Gly  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Glu Lys Pro Glu  Glu Tyr Glu Lys Ile  Glu Ala Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Ile  Tyr Ala Pro Glu Lys  Asn Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Gln Gly Arg Val Gly  Ala Lys Val 
    1145                 1150                 1155             


Thr Ser  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Glu Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Met Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Val Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Val Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Glu Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asn Ala 
    1280                 1285                 1290             


Lys Asp  Lys Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Asp  Ala Glu Asp Ala Asp  Ser Lys Lys Pro Val  Ile Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Glu  Asp Glu Asp 
    1325                 1330                 1335             


Lys Gln  Lys Gly Lys Glu Asn  Arg Gly Lys Lys Asn  Thr Glu Thr 
    1340                 1345                 1350             


Arg Ser  Asp Ala Glu Lys Asn  Asn Asn Glu Arg Leu  Ser Tyr Asn 
    1355                 1360                 1365             


Pro Phe  Ala Asn Phe Asp Phe  Lys Leu Pro Asn Lys  
    1370                 1375                 1380 


<210>  322
<211>  1287
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  322

Met Arg Ile Gly Lys Val Gln Gly Arg Thr Phe Thr Gly Phe Asp Asn 
1               5                   10                  15      


Ala Arg Gly Lys Thr Leu Arg Arg Arg Leu Leu Thr Arg Pro Asp Asn 
            20                  25                  30          


Glu Ala Arg Ser Leu Ser Glu His Leu Ala His Asp Pro Lys Ala Leu 
        35                  40                  45              


Ile Gly Gln Ala Ile Ser Arg Ile Asp Thr Ile Tyr Gln Lys Pro Lys 
    50                  55                  60                  


Thr Gly Lys Pro Thr Pro Glu Gln Phe Gly His Arg Asp Thr Leu Gly 
65                  70                  75                  80  


Trp Ala Tyr Trp Lys Leu Leu Val Ala Ser Tyr Pro Glu Val Glu Gly 
                85                  90                  95      


His Arg Asp Leu Phe Val Arg Arg Leu His Pro Tyr Gly Asp Thr Pro 
            100                 105                 110         


Pro Lys Ser His Gly Gln Lys Glu Gly Glu His Gln Lys Gly Gly Lys 
        115                 120                 125             


Pro Gln Leu Glu Gly Arg Trp His Gly Val Met Ala Gln His Gly Lys 
    130                 135                 140                 


Asn Pro Asp Gln Ile Ala Ala Arg Leu Phe Asp His Leu His Asn Ser 
145                 150                 155                 160 


Glu Leu Arg Phe Gly Gly Thr Ala Ser Gly Glu Pro Arg Thr Arg Pro 
                165                 170                 175     


Gly Lys Glu Ala Thr Pro Thr Gly Leu Ile Gly Ala Arg Ala Lys Thr 
            180                 185                 190         


Ile Glu His Ser Val Leu Pro Arg Asp Ala Lys Arg Phe Val Ala Glu 
        195                 200                 205             


Trp Arg Gly Glu Asp Gln Glu Arg Tyr Ala Gly Ala Arg Asp Ile Ala 
    210                 215                 220                 


Ala Ala Ile Ser Ala Gly Leu Asn Asp Lys Asp Gln Lys Ser Gly Ser 
225                 230                 235                 240 


Gly Arg Lys Ser Ala Val Ile Gly Lys Leu Leu Ser Asp His Leu Glu 
                245                 250                 255     


Thr Leu Thr Gly Asn Arg Lys Cys Arg Phe Asp Pro Lys Ser Thr Ala 
            260                 265                 270         


Glu Thr Leu Glu Leu Arg Asp Gly Glu Ser Val Asp Asp Arg Arg Arg 
        275                 280                 285             


Ile Leu Glu Leu His Ala Glu Val Lys Ala Thr Tyr Lys Arg Met Ala 
    290                 295                 300                 


Ala Trp Lys Pro Ala Lys Leu Pro Arg Asn Ser Asp Glu Leu Phe Arg 
305                 310                 315                 320 


Leu Val Arg Gln Gln Ala Asp Asn Arg Ile Leu Asn His Leu Val Arg 
                325                 330                 335     


Val Gly Arg Ile Ser Val Tyr Ser Glu Gln Ser Asp Ala Leu Ser Glu 
            340                 345                 350         


Ser Gln Phe Trp Thr Ser Gly Gly Gln Thr Gln Ile Lys Glu Ser Glu 
        355                 360                 365             


Val Phe Ala Arg Leu Trp Ile Gly Ala Ile Ser Arg Ala Ser Tyr Ser 
    370                 375                 380                 


Met Lys Ala Trp Leu Glu Pro Glu Gly Thr Val Phe Asn Pro Ser Ile 
385                 390                 395                 400 


Asn Asp Phe Asp Val Thr Ser Ser His Asn Thr Asn Arg Ile Leu Glu 
                405                 410                 415     


Asp Ser Gly Arg Leu Ser Asn Ala Met Ala Arg Arg Ala Ile Tyr Phe 
            420                 425                 430         


Gly Glu Thr Pro Glu Phe Asp Ala Leu Gly Glu Glu Asp Gln Arg Val 
        435                 440                 445             


Leu Val Lys Lys Cys Leu Asp Ala Leu Ser Ala Cys Arg Asn Arg Thr 
    450                 455                 460                 


Phe His His Gly Gln Arg Ala Lys Phe Leu Lys Glu Val Arg Lys Gly 
465                 470                 475                 480 


Leu Lys Glu Lys Glu Ala Asp Ser Ala Gly Pro Ala Ala Trp Glu Gly 
                485                 490                 495     


Ile Arg Glu Val Ile Gln Ala Asp Ala Arg Asn Leu Gly Ala Arg Leu 
            500                 505                 510         


Leu Gln Asp Leu Thr Gly Ala Lys Val His Ser Phe Ala Thr Asp Pro 
        515                 520                 525             


Glu Phe Arg His Leu Tyr Glu Ser Val Ala Ala Thr Leu Thr Ala Gly 
    530                 535                 540                 


Gly Glu Leu Glu Ala Ala Leu Pro Arg Leu Lys Asn Val Leu Lys Arg 
545                 550                 555                 560 


Ala Glu Gly Val Arg Cys Tyr Leu Asp Thr Pro Ser Gln Arg Arg Glu 
                565                 570                 575     


Gly Asp Glu Ser Leu Ile Ala Arg Leu Pro Val Ala Pro Val Pro Arg 
            580                 585                 590         


Glu Leu Asp Asp Ala Ala Thr Lys Ala Arg His Ser Ala Leu Leu Arg 
        595                 600                 605             


Leu Tyr Asp Gly Pro Phe Arg Pro Trp Ala Thr Glu Leu Arg Gly Glu 
    610                 615                 620                 


Arg Leu Ser Asp Tyr Ala Ala Arg Ala Lys Arg Leu Ala Thr Arg Leu 
625                 630                 635                 640 


Ala Lys Ser Thr Asn Thr Ala Ser Pro Tyr Pro Asp Ser Val Glu Gly 
                645                 650                 655     


Arg Ser Val Arg Leu Arg Asp Pro Ile Thr Ala Asp Thr Ala Pro Glu 
            660                 665                 670         


Thr Leu Lys Thr Tyr Leu Ser Ala Leu Thr Ala Glu Thr Ala Thr Glu 
        675                 680                 685             


Phe Arg Val Gln Lys Gly Tyr Glu Ser Asp Gly Glu Lys Ala Lys Glu 
    690                 695                 700                 


Gln Ala Glu Phe Ile Glu Asp Phe Arg Arg Asp Met Ile Ala Leu Ala 
705                 710                 715                 720 


Phe Gln Asp Phe Ile Arg Asp His Gly Phe Ala Trp Leu Leu Asp Ile 
                725                 730                 735     


Ala Ser Lys Ala Glu Pro Ser Asn Asp Ala Pro Asn Leu Pro Asp Pro 
            740                 745                 750         


Val Asp Thr Gly Lys Asp Thr Val Phe Glu Asp Trp Gln Ala Leu Leu 
        755                 760                 765             


Tyr Leu Phe Leu His Phe Val Pro Ala Asp Asp Val Ser Gln Leu Leu 
    770                 775                 780                 


His Gln Leu Arg Lys Trp Asp Ala Leu Gln Asp Lys Tyr Glu Leu Ala 
785                 790                 795                 800 


Glu Pro Gly Glu Thr Leu Gly Gln Thr Lys Ala Asp Thr Arg Lys Ile 
                805                 810                 815     


Val Gly Gln Phe Arg Asp Cys Leu Thr Leu Phe Leu Lys Thr Gly Asp 
            820                 825                 830         


Ala Arg Phe Asp Gly Glu Gly Val Glu Leu Pro Leu Ser Asp Phe Gln 
        835                 840                 845             


Glu Leu Phe Glu Ser Pro Ala Thr Phe Lys Glu Leu Phe Leu Ala Glu 
    850                 855                 860                 


Pro Ala Glu Asn Asp Ala Ser Glu Thr Asp Asp Gln Asp Ala Pro Gly 
865                 870                 875                 880 


Glu Lys His Arg Val Thr Arg Thr Arg Arg Gly Leu Arg Gln Ile Leu 
                885                 890                 895     


Arg Tyr Asn His Met Pro Val Leu Arg Asp Leu Phe Leu Ala His Lys 
            900                 905                 910         


Val Thr Asp Ala Glu Val Asp Gly Leu Gln Ala Leu Glu Val Asp Asp 
        915                 920                 925             


Pro Gln Thr Gly Glu Ser Gln Ile Gly Ala Ala Gln Arg Ile Arg Thr 
    930                 935                 940                 


Glu Ile His His His Thr Ser Asn Asp Lys Gln Ile Ser Glu Ala Lys 
945                 950                 955                 960 


Val Glu Glu Tyr Arg Arg Ala Leu Ser Thr Ile Glu Arg His Arg Phe 
                965                 970                 975     


Leu Val Gly Arg Val Tyr Leu Gly Asp His Ile Arg Val His Lys Leu 
            980                 985                 990         


Met Met Asp Val Met Gly Arg Leu  Val Asp Phe Ala Gly  Ala Trp Glu 
        995                 1000                 1005             


Arg Glu  Ala Ala Asp Gly Asp  Arg Lys Gly Phe Ile  Ser Arg Ala 
    1010                 1015                 1020             


Ile Ala  Leu Pro Glu Val Ala  Glu Gly Tyr Ala Ala  Asp Arg Leu 
    1025                 1030                 1035             


Lys Thr  Val Ala Arg Arg Val  Leu Asp Asp Gly Glu  Ala Arg Arg 
    1040                 1045                 1050             


Ile Arg  Asn Asp Leu Gly His  Phe Asn Asp Leu Ala  Pro Thr Ser 
    1055                 1060                 1065             


Gly Pro  Ala Asn Leu Thr Phe  Val Val Asn Arg Ala  Arg Arg Met 
    1070                 1075                 1080             


Met Arg  His Asp Arg Lys Arg  Lys Asn Ala Val Thr  Lys Ser Val 
    1085                 1090                 1095             


Ile Glu  Ile Leu Asn Arg Gln  Gly Leu Gly Ile Glu  Trp Thr Met 
    1100                 1105                 1110             


Arg Asn  His Glu Leu Cys Glu  Ala Lys Leu Trp Gln  Asn Pro Val 
    1115                 1120                 1125             


Lys His  Leu Gly Phe Ala Thr  Leu Glu Gly Arg Gly  Lys Lys Trp 
    1130                 1135                 1140             


Arg Arg  Pro Phe Glu Ala Arg  Tyr Gly Asp Ala Tyr  Met Ala Met 
    1145                 1150                 1155             


Val Ala  Gln Leu Phe Asp Gly  Thr Val Thr Ser Pro  Pro Ala Lys 
    1160                 1165                 1170             


Gly Pro  Pro Gln Ser Gly Lys  Ser Gly Gly Lys Pro  Gly Lys Gly 
    1175                 1180                 1185             


Ala Glu  Gly Gly Ala Lys Glu  Lys Ser Arg Ser Pro  Thr Arg Met 
    1190                 1195                 1200             


Glu Glu  Gly Gly Val Tyr Glu  Gly Arg Val Ala Lys  Ala Lys Ser 
    1205                 1210                 1215             


Asp Lys  Gly Phe Gly Phe Leu  Leu Val Glu Gly Ala  Gln Glu Glu 
    1220                 1225                 1230             


Ile Phe  Leu His Ile Tyr Gly  Ile Ser Gly Asn Arg  Pro Ala Arg 
    1235                 1240                 1245             


Ile Glu  Asn Gly Gln Arg Tyr  Arg Phe Thr Leu Gly  Ile Asp Arg 
    1250                 1255                 1260             


Asp Arg  Glu Arg Arg Lys Glu  Arg Ala Trp Val Ala  Arg Glu Ala 
    1265                 1270                 1275             


Val Arg  Ile Asp Glu Asn Arg  Ser Lys 
    1280                 1285         


<210>  323
<211>  1373
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  323

Met Ala Lys His Leu Arg Pro Ile Gly Glu Ser Tyr Thr Asp Phe Leu 
1               5                   10                  15      


Asp Glu Thr Glu Phe Val Arg Leu Gly Arg Gly Leu His Arg Gly His 
            20                  25                  30          


His Gly Val Gln Ile Pro Pro Thr Glu Leu Pro Ser Tyr Leu Ala Glu 
        35                  40                  45              


Tyr Arg Lys Ala Leu Met Arg Gln Val Val Ala Val Leu Asp Lys Val 
    50                  55                  60                  


Val Gly Lys Arg Arg Arg Leu Ser Gly Met His Pro Glu Ala Tyr Arg 
65                  70                  75                  80  


Asp Arg Val His Leu Ala Glu Ala Leu Trp Val Arg Leu Val Ala Arg 
                85                  90                  95      


Val Lys Glu Ile Gly Thr Pro Pro Asp Pro Ser Glu Leu Leu Asp Leu 
            100                 105                 110         


Arg Arg Met Trp Asn Ala Lys Ala His Pro Tyr Ala Glu Tyr Asp Val 
        115                 120                 125             


Val Pro Arg Ala Pro Leu Asn Asp Gly Asn Gly Gln Lys Ile Leu Glu 
    130                 135                 140                 


Cys Arg Glu Val Asp Asp Pro Lys Ile Glu Arg Ser Asp Phe Glu Gly 
145                 150                 155                 160 


Arg Trp His Gly Arg Phe Trp Gln Ser Glu Pro Gly Pro Val Asp Tyr 
                165                 170                 175     


Asn Ala Ile Ala Asp Arg Ile Phe Ala His Leu Phe Asp Gln Glu Ala 
            180                 185                 190         


Val Ile Gly Gly Gly Pro Arg Arg Glu Gly Asn Val Thr Val Pro Asp 
        195                 200                 205             


Glu Asp Ile Asn Gly Gln Pro Gly Pro Ala Thr Gly Lys Gly Leu Ile 
    210                 215                 220                 


Ile Ala Arg Gly Gln Ser Ile Val Lys Ser Ala Ser Asp Pro Arg Arg 
225                 230                 235                 240 


Ser Ser Lys Lys Val Gln Arg Thr Trp Asp Lys Ala Val Glu Arg Arg 
                245                 250                 255     


Tyr Phe Gly Asp Asp Gly Lys Gly Gly Ser Asp Ile Ala Lys Ala Ile 
            260                 265                 270         


Tyr Glu Glu Leu Gly Asp Pro Ala Thr Leu Ala Asp Pro Ile Tyr Ala 
        275                 280                 285             


Ser Trp Phe Gly Ser Arg Leu Tyr Asp His Phe Gly Ser Phe Lys Asn 
    290                 295                 300                 


Ser Leu Pro Leu Glu Leu Lys Asp Pro Phe Lys Glu Gln Ile Trp Ala 
305                 310                 315                 320 


Leu His Asn Ser Val Arg Gln Phe Tyr Gln Arg Met Ala Lys Ser Asp 
                325                 330                 335     


Arg Phe Arg Leu Ala Leu Gln Asn Ala Arg Ser Glu Val Pro Asp Arg 
            340                 345                 350         


Ser Glu Leu Leu Ala Leu Leu Pro Lys Asp His Asp His Leu Leu Leu 
        355                 360                 365             


Val Leu Gly Gly Lys Lys Lys Asn Ala Glu Met Ser Glu Leu Ile Arg 
    370                 375                 380                 


Leu Gly Lys Leu Phe Val His Ala Ser Asp Val Leu His Asp Phe Asp 
385                 390                 395                 400 


Ala Asn Asp Ala Ala Ala Leu Asp Ala Phe Lys Arg Arg Met Ser Phe 
                405                 410                 415     


Leu Ala Thr Ser Ile Gly Gln Ser Glu Ile Lys Gln Thr Glu Thr Phe 
            420                 425                 430         


Ala Arg Thr Trp Arg Gly Ala Val Gly Leu Thr Leu Arg Thr Val Lys 
        435                 440                 445             


Gly Leu Ala Asp Pro Arg Gly Ile Ile Gly Thr Pro Asp Asn Arg Asp 
    450                 455                 460                 


Leu Gly Thr Ala Gly Pro Met Lys Asp Ala Phe Asn Lys Phe Asp Gln 
465                 470                 475                 480 


Pro His Phe Gln Gln His Met Thr Ile Ile Phe Gly Asn Lys Glu Leu 
                485                 490                 495     


Gln Ala Glu Gly Asn Pro Thr Arg Ser Ser Val Phe Thr Ala Asn Gly 
            500                 505                 510         


Asp Lys Asp His Gln Ala Glu Leu Leu Trp Gly Phe Leu Cys Val Val 
        515                 520                 525             


Arg Ser Val Arg Asn Arg Thr Asn His Tyr Asn Val Arg Arg Ala Leu 
    530                 535                 540                 


Leu Arg Leu Leu Asp Glu Gly Ile Val Ser Pro Met Pro Ser Asp Pro 
545                 550                 555                 560 


Lys Lys Glu Arg Val Glu Asn Arg Asn Leu Cys Thr Val Ser Pro Thr 
                565                 570                 575     


Ala Leu Glu Ala Phe Arg Arg Leu Leu Asn Phe Asp Leu Ala Ile Gln 
            580                 585                 590         


Lys Glu Ala Val Arg Thr Ala Leu Glu Gln Ala Lys Ala Ser Glu Phe 
        595                 600                 605             


Val Glu Glu Gly Lys Leu Arg Gly Leu Val Ser Glu Leu Ala Gly Thr 
    610                 615                 620                 


Glu Asp Met Pro Ala Leu His Ile Pro Arg Phe Ser Ala Val Met Asp 
625                 630                 635                 640 


Lys Val Arg Arg Leu Ala Asp Asn Arg Asp Val Gly Leu Asp Pro Ile 
                645                 650                 655     


Leu Ser Thr Leu Gln Arg Ser Leu Pro Pro Thr Asp Lys Gln Ala Glu 
            660                 665                 670         


Ser Asp Ala Ala Arg Cys Arg Tyr Arg Leu Leu Leu Glu Leu Tyr Lys 
        675                 680                 685             


Ser Gly Phe Arg Ser Trp Phe Ser Gly Ile Gln Ser Asn Glu Glu Asn 
    690                 695                 700                 


Asn Arg Glu Ile Cys His Trp Ala Val Lys Gln Val Gly Arg Ala Lys 
705                 710                 715                 720 


Asp Ala Arg Lys Ser Glu Tyr Asp Lys Lys Thr Lys Arg His Tyr Arg 
                725                 730                 735     


Ser Pro Asn Ser Leu Ile Asp Asp Leu Gly Leu Asp Lys Phe Asp Asp 
            740                 745                 750         


Leu Thr Asp Leu Leu Glu Ala Leu Ala Ser Gln Ser Thr Arg Glu His 
        755                 760                 765             


Asp Gln Asn Leu Lys Tyr Val Pro Asp Ala Arg Val Gln Ser Gln Met 
    770                 775                 780                 


Ser Asn Arg Ile Glu Glu Phe Arg Gln Glu Leu Phe Ala His Ile Phe 
785                 790                 795                 800 


Thr Lys Tyr Leu Asp Thr His Asp Phe Gly Trp Ile Gly Ala Ile Glu 
                805                 810                 815     


Val Arg Arg Glu Ala Cys Asp Leu Ala Asp Val Val Ser Ala Phe Glu 
            820                 825                 830         


Val Arg Asp Gln Lys Phe Asp Ala Asp Trp His Ser Gln Phe Tyr Ala 
        835                 840                 845             


Trp Leu Tyr Met Val Pro Pro Ile Glu Ala Ser Arg Leu Arg His Gln 
    850                 855                 860                 


Met Arg Lys Ser Ala Val Met Asp Asp Lys Trp Ser Thr Thr Leu Glu 
865                 870                 875                 880 


Leu Thr Ser Gly Asp Arg Lys Thr Arg Asp Asp His Ala Gln Asp Val 
                885                 890                 895     


Leu Ala Asp Met Asp Arg Leu Phe Ser Leu Tyr Thr Lys Val Gln Ala 
            900                 905                 910         


Ala Gly Phe Asn Gly Gln Glu His Glu Ser Ala Leu Gly Ser Lys Ser 
        915                 920                 925             


Leu Phe Tyr Glu Asp Gly Asn Gln Phe Asp Glu Val Tyr Ser Pro Asp 
    930                 935                 940                 


Thr Glu Thr His Asn Lys Thr Phe Pro Gly Thr Arg Arg Gly Leu Arg 
945                 950                 955                 960 


Gln Leu Val Arg Tyr Ala His Leu Pro Ala Leu Glu Gly Val Phe Lys 
                965                 970                 975     


Lys His Arg Ile Thr Lys Ala Glu Val Glu Thr Phe Val Ala Leu Tyr 
            980                 985                 990         


Asp Glu Asn Arg Arg Asp Pro Gly  Ser Val Ala His Met  Leu Arg Arg 
        995                 1000                 1005             


Glu Lys  Leu Arg Thr Glu Ile  Leu Arg Ser Ile His  Asp Gly Pro 
    1010                 1015                 1020             


Lys Pro  Lys Asp Lys Asp Phe  Trp Pro Lys Leu Glu  Ala Lys Cys 
    1025                 1030                 1035             


Leu Glu  Tyr Arg Thr Val Ala  Thr Glu Thr Ala Ile  Tyr Asn Phe 
    1040                 1045                 1050             


Gln Ala  Asn Ala Ala Arg Leu  Asn Asp His Ala Arg  Leu His Gln 
    1055                 1060                 1065             


Ile Val  Met Arg Val Val Ala  Arg Leu Thr Asp Tyr  Ala Leu Ile 
    1070                 1075                 1080             


Trp Glu  Arg Asp Arg Leu Phe  Ala Phe Val Gly Met  Leu Tyr Arg 
    1085                 1090                 1095             


Gln Thr  Gly Gly Thr Gly Ile  Asn Pro Ala Met Arg  His Ala Glu 
    1100                 1105                 1110             


Lys Thr  Asn Ala Pro Pro Arg  Ile Gly Ile Leu Val  Ser Asp Ser 
    1115                 1120                 1125             


Ala Leu  Ala Lys Lys Leu Asn  Ser Asn Ser Ala Glu  Val Phe Ile 
    1130                 1135                 1140             


Pro Tyr  Leu Asp Thr Glu Thr  Gly Phe Asp Ala Pro  Arg Phe Asp 
    1145                 1150                 1155             


Asp Leu  Cys Thr Leu Leu Ser  His Glu His Ala Lys  Glu Phe Arg 
    1160                 1165                 1170             


Phe His  Phe Leu Glu Val Gly  Glu Glu Asn Ser Lys  Asp Glu Ala 
    1175                 1180                 1185             


Arg Arg  Leu Asn Glu Glu Thr  Met Gly His Arg Lys  Arg Pro Ala 
    1190                 1195                 1200             


Phe Lys  Arg Gly Thr Arg Arg  Gln Gly Ile Arg Asn  Asp Leu Ala 
    1205                 1210                 1215             


His His  Asn Val Leu Asp Leu  Ala Gly Gly Ala Gly  Pro Asn Leu 
    1220                 1225                 1230             


Thr Tyr  Val Val Asn Ala Val  Arg Ser Leu Leu Ser  Tyr Asp Arg 
    1235                 1240                 1245             


Lys Leu  Lys Asn Ala Val Pro  Lys Ser Ile Lys Arg  Ile Leu Gly 
    1250                 1255                 1260             


Glu Glu  Gly Leu Ile Ile Glu  Trp Gln Met Asn Tyr  Asp Arg Leu 
    1265                 1270                 1275             


Lys Lys  Pro Thr Val Tyr Pro  Asn Val Glu Thr His  Leu Thr Met 
    1280                 1285                 1290             


Val Pro  Pro Arg His Met Thr  Ala Pro Val Ser Phe  Thr Leu Pro 
    1295                 1300                 1305             


Arg Ala  Ser Val Arg Leu Ala  Ser Met Val Lys Ala  Val Phe Asp 
    1310                 1315                 1320             


Phe Gly  Ser Ser Gly Tyr Gly  Glu Glu Arg Met Ile  Gly Gly Arg 
    1325                 1330                 1335             


Thr Ala  Lys Gln Ala Val Tyr  Pro Asp Asp Phe Thr  Arg Arg Phe 
    1340                 1345                 1350             


Pro Gln  Thr Pro Met Gly Leu  Lys Gln Ala Thr Arg  Leu Val Phe 
    1355                 1360                 1365             


Ala Ser  Glu Asn Ser 
    1370             


<210>  324
<211>  1330
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  324

Met Lys Arg Glu Lys Asn Ile Thr Ile Met Lys Ile Ser Lys Val Asn 
1               5                   10                  15      


His Arg Arg Thr Ala Val Ala Leu Asn Gly Asp Lys Ser Glu Leu Gly 
            20                  25                  30          


Gly Ile Leu Tyr Glu Ala Pro Val Gln Lys Asp Lys Asn Gly Asn Tyr 
        35                  40                  45              


Asn Asp Val Ile Ala Glu Thr Gly Lys Val Val Asn Glu Ala Leu Asp 
    50                  55                  60                  


Lys Lys Ser Arg Leu Tyr Thr Pro Phe Asn Asn Gln Lys Val Ile Ile 
65                  70                  75                  80  


Asp Lys Asn Leu Gln Arg Tyr Ala Asn Asn Leu Lys Arg Cys Tyr Ile 
                85                  90                  95      


Asn Phe Val Lys Gln Tyr Val Asn Asn Lys Ser Phe Asn Tyr Lys Ala 
            100                 105                 110         


Met Gln Phe Ile Pro Asp Ile Gln Asn Pro Lys Thr Asn Asp Ala Val 
        115                 120                 125             


Asn Tyr Arg Thr Asp Arg Asp Asn Val Tyr Asn Lys Asn Lys Tyr Tyr 
    130                 135                 140                 


Asp Lys Gln Thr Lys Ser Lys Ser Lys Lys Phe Ile Tyr Glu Lys Ile 
145                 150                 155                 160 


Val Ile Pro Gln Asn Glu Gln Asn Ile Val Ile Ser Ala Leu Val Asn 
                165                 170                 175     


Cys Ser Leu Arg Lys Ser Leu Arg Lys Asp Val Ser Tyr Lys Thr Lys 
            180                 185                 190         


Ser Gly Glu Ile Lys Thr Tyr Asn Leu Pro Glu Leu Val Lys Lys Ser 
        195                 200                 205             


Met Arg Phe Tyr Cys Leu Glu Gly Gln Arg Glu Pro Asp Glu Lys Glu 
    210                 215                 220                 


Lys Tyr Glu Met Tyr Ile Leu Phe Ser Tyr Met Lys Glu Asp Lys Arg 
225                 230                 235                 240 


Thr Lys Asn Thr Asp Leu Leu Val Lys Ser Ile Ser Asn Gln Asn Thr 
                245                 250                 255     


Lys Val Lys Val Glu Asp Ile Asp Gly Asn Lys Leu Leu Lys Leu Ser 
            260                 265                 270         


Ile Ala Asp Thr Lys Lys Lys Pro Leu Trp Glu Tyr Leu Ile Lys Tyr 
        275                 280                 285             


Ala Asp Ser Ser Arg Gln Arg Glu Leu Met Tyr Asp Ile Arg Lys Lys 
    290                 295                 300                 


Ile Ile Leu Tyr Val Ala Gly Ile Glu Glu Tyr Glu Asn Ile Lys Glu 
305                 310                 315                 320 


Asp Ser Gly Leu Ser Lys Val Ser Trp Ser Lys Tyr Asn Ile Ser Asp 
                325                 330                 335     


Asn Lys Met Phe Phe Asp Ile Asn Ser Cys Thr Asp Lys Arg Lys Gln 
            340                 345                 350         


Asn Leu Glu Ile Lys Ile Arg Glu Ala Asn Ile Glu His Tyr Arg Asn 
        355                 360                 365             


Ala Ser Ser Lys Leu Cys Asp Asp Glu Ser Ile Phe Trp Phe Gln His 
    370                 375                 380                 


Phe Glu Gly Val Ile Glu Thr Leu Phe Ser Lys Lys Ser Lys Ile Ser 
385                 390                 395                 400 


Glu Glu Arg Leu Gly Cys Ala Tyr Ile Cys Asp Tyr Leu Trp Lys Asp 
                405                 410                 415     


Phe Leu Ser Tyr Leu Ala Ala Lys Tyr Ile Asp Leu Gly Lys Gly Val 
            420                 425                 430         


Tyr His Phe Thr Met Lys Asp Lys Leu Asp Met Leu Asn Lys Asn Glu 
        435                 440                 445             


Ala Ile Thr Asp Leu Arg Phe Gly Ile Val Ser Glu Lys Tyr Glu Lys 
    450                 455                 460                 


Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Glu Leu 
465                 470                 475                 480 


Asp Arg Asn Ile Ala Ala Tyr Val Thr Phe Ala Ala Asp Ile Phe Ala 
                485                 490                 495     


Lys Ser Val Ile Lys Ser Asp Tyr Arg Thr Lys Lys Asp Asn Asn Ser 
            500                 505                 510         


Asp Val Leu Gln Tyr Ser Asp Lys Glu Phe Arg Asn Ser Glu Val Ile 
        515                 520                 525             


Arg Asp Asn Ala Glu Lys Asn Ile Leu Gln Tyr Trp Gly Gly Tyr Ser 
    530                 535                 540                 


Arg Trp Gly Thr Glu Asn Ser Lys Leu Pro Glu Asn Asn Lys Val Ser 
545                 550                 555                 560 


Asp Phe Asp Lys Leu Asp Val Ser Asp Leu Cys Ile Asp Ile Lys Lys 
                565                 570                 575     


His Leu Ala Gly Ile Arg Asn Ser Ser Val His Tyr Thr Thr Lys Ile 
            580                 585                 590         


Lys Asn Glu Ser Ala Ala Asp Gly Ser Asn Val Lys Ile Leu Phe Glu 
        595                 600                 605             


Lys Asp Leu Ala Asp Ile Asn Ile Ile Tyr Ala Asp Lys Tyr Tyr Ser 
    610                 615                 620                 


Asn Asn Val Trp Met Phe Tyr Ser Leu Glu Asp Ile Asn Lys Leu Ile 
625                 630                 635                 640 


Ala Phe Leu Tyr Lys Glu Lys Arg Val Ile Arg Gln Val Gln Ile Pro 
                645                 650                 655     


Ser Phe Ser Arg Ile Leu Lys Arg Lys Ala Met Gln Asp Val Ile Asn 
            660                 665                 670         


Glu Ile Phe Lys Asp Asp Phe Asp Glu Asn Ile Val Asn Pro Glu Leu 
        675                 680                 685             


Lys Glu Lys Tyr Arg Asn Ser Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
    690                 695                 700                 


Tyr Asn Ala Phe Ile Ile Gln Pro Glu Leu Lys Glu Lys Phe Lys Asp 
705                 710                 715                 720 


Lys Ile Lys Thr Met Lys Ser Glu Leu Tyr Asn Lys Leu Lys Thr Ile 
                725                 730                 735     


Asp Lys Lys Glu Tyr Lys Ala Leu Tyr Cys Met Leu Ser Asn Glu Glu 
            740                 745                 750         


Ser Ala Leu Lys Asn Phe Ala Asp Arg Ile Tyr Ser Val Asp Gly Asp 
        755                 760                 765             


Asn Val Ser Phe Ala Asp Ile Cys Lys Ile Leu Met Thr Asp Tyr Asn 
    770                 775                 780                 


Met Gln Asn Gln Glu Lys Lys Asn Ile Glu Ser Met Glu Gln Lys Lys 
785                 790                 795                 800 


Lys Asn Lys Gly Lys Asp Glu Asn Tyr Lys His Phe Pro Leu Leu Leu 
                805                 810                 815     


His Lys Val Leu Lys Glu Leu Phe Ile Glu Tyr Leu Lys Gln Thr His 
            820                 825                 830         


Glu Leu Glu Phe Leu Arg Asn Asn Ile Cys Ile Lys Ser Asp Val Thr 
        835                 840                 845             


Met Glu Ser Phe Glu Ser Gln Ile Lys Gly Val Glu Ile Tyr Lys Asp 
    850                 855                 860                 


Leu Lys Glu Lys Ile Asp Lys Asn Asn Ser Leu Leu Asp Trp Tyr Val 
865                 870                 875                 880 


Ile Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asn 
                885                 890                 895     


Ile Lys Asn Tyr Ile Gln Phe Ala Thr Asn Ile Asp Lys Arg Ala Glu 
            900                 905                 910         


Ser Val Lys Asn Leu Thr Glu Ser Gly Met Val Lys Arg Ile Gln Tyr 
        915                 920                 925             


Tyr Asp Asp Ile Val Arg Thr Leu Glu Phe Ser Ala Gln Tyr Ile Gly 
    930                 935                 940                 


Lys Ile Ser Asn Asn Ile Asn Asp Tyr Phe Asn Ser Glu Asp Glu Tyr 
945                 950                 955                 960 


Val Ser Phe Leu Ser Lys Tyr Val Gly Phe Ile Asn Asp Lys Ser Glu 
                965                 970                 975     


Asp Val Leu Thr Glu Leu Lys Asp Phe Cys Arg Glu Lys Ile Asn Asn 
            980                 985                 990         


Gly Ser Gln Ile Ile Gly Ile Tyr  Tyr Gly Gly Asp Asn  Val Ile Ile 
        995                 1000                 1005             


Asn Arg  Asn Val Ile Tyr Ala  Gln Met Tyr Ser Asn  Ala Glu Val 
    1010                 1015                 1020             


Phe Ser  Asn Ile Tyr Lys Lys  Val Thr Lys Asn Asp  Ile Ile Asn 
    1025                 1030                 1035             


Tyr Tyr  Glu Lys Gln Asn Asp  Leu Lys Asp Val Phe  Lys Ser Gly 
    1040                 1045                 1050             


Val Cys  Gln Asn Glu Asp Glu  Gln Arg Ser Leu Cys  Glu Phe Gln 
    1055                 1060                 1065             


Gln Leu  Lys Asn Arg Ile Glu  Leu Thr Glu Leu Ser  Thr Tyr Ala 
    1070                 1075                 1080             


Asp Met  Val Asn Asp Phe Met  Ala Gln Phe Val Glu  Trp Ala Tyr 
    1085                 1090                 1095             


Leu Arg  Glu Arg Asp Leu Met  Tyr Phe Gln Leu Gly  Ile His Tyr 
    1100                 1105                 1110             


Ile Arg  Leu Phe Tyr Ser Asp  Asn Val Leu Asp Glu  Lys Tyr His 
    1115                 1120                 1125             


Lys Leu  Ser Asp Asn Val Ile  Asp Ile Glu Glu Gly  Ala Leu Leu 
    1130                 1135                 1140             


Tyr Gln  Ile Val Ala Met Tyr  Asp Tyr Glu Leu Arg  Ile Phe Glu 
    1145                 1150                 1155             


Thr Asp  Asn Ser Gly Asn Ala  Lys Arg Ile Gly Gln  Gly Gly Pro 
    1160                 1165                 1170             


Gly Lys  Ser Ile Pro Val Phe  Leu Lys Lys Tyr Cys  Asn Gly Thr 
    1175                 1180                 1185             


Asp Val  Tyr Glu Cys Gly Leu  Glu Leu Phe Glu Asp  Ile Asn Gln 
    1190                 1195                 1200             


His Glu  His Ile Ile Arg Phe  Arg Asn Asp Ile Ala  His Met Arg 
    1205                 1210                 1215             


Tyr Met  Ser Asn Gln Ala Met  Asn Ile Met Ser Ile  Val Ser Asn 
    1220                 1225                 1230             


Ile Tyr  Lys Ser Phe Phe Ala  Tyr Asp Thr Lys Leu  Lys Lys Ser 
    1235                 1240                 1245             


Ile Ser  Leu Val Phe Lys Asn  Ile Leu Met Arg Tyr  Gly Val Ile 
    1250                 1255                 1260             


Ala Asp  Leu Val Phe Ser Tyr  Asn Asn Lys Asn Gln  Ser Ile Lys 
    1265                 1270                 1275             


Asp Asp  Met Asp Ile Asn Ile  Ile Asn Ile Lys Asn  Leu Lys Ser 
    1280                 1285                 1290             


Asp Lys  Tyr Val Tyr Lys Ile  Val Asn Glu Asp Ile  Val Lys Gln 
    1295                 1300                 1305             


Val Glu  Ile Glu Ile Arg Asn  Gln Val Phe Leu Glu  Gln Leu His 
    1310                 1315                 1320             


Asn Leu  Leu Tyr Phe Ser Arg  
    1325                 1330 


<210>  325
<211>  1216
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  325

Met Arg Ile Ile Arg Pro Tyr Gly Glu Ser Arg Thr Glu Arg Ser Asp 
1               5                   10                  15      


His Leu Lys Arg Val Leu Tyr Asp Lys Thr Gln Ser Arg Glu Arg His 
            20                  25                  30          


Glu Ile Gly Arg Tyr Ala Gln Ala His Gly Glu Leu Val Ile Ala Gln 
        35                  40                  45              


Trp Ile Ser Ile Ile Asp Lys Ile Ala Thr Lys Pro Gln Gly Glu Gln 
    50                  55                  60                  


Gly Ala Thr Glu Glu Gln Tyr Lys Leu Arg Asp Arg Leu Gly Glu Ala 
65                  70                  75                  80  


Ala Trp Thr Arg Leu Lys Ala Asp Gly Arg Leu Glu Leu Asp Asp Ala 
                85                  90                  95      


Lys Arg Ala Glu Phe Leu Ser Ala Val Trp Asn Phe Lys Ile His Pro 
            100                 105                 110         


Tyr Gly Glu Arg Arg Phe Lys Pro Lys Gln Pro Arg His Gly Asn Leu 
        115                 120                 125             


Gly Ser Ser Pro Ser Ala Arg Gly Arg Trp Tyr Met Arg Phe Ala Gly 
    130                 135                 140                 


Asp Thr Ser Pro Glu Arg Val Asn Ala Glu Asp Val Val Gln Arg Ile 
145                 150                 155                 160 


Ser Glu His Leu Tyr Ser Ser Glu Tyr Arg Lys Ser Ala Ser Ala Lys 
                165                 170                 175     


Lys Lys Thr Thr Gly Leu Ile Ala Ala Arg Ala Ala Ser Ile Glu Lys 
            180                 185                 190         


Asn Thr Leu Arg Ala Leu Pro Asn Ser Thr Ala Gly Trp Ser Lys Ser 
        195                 200                 205             


Asp Glu Ala His Tyr Ala Lys Phe Gly Asp Val Ala Ala Glu Ile His 
    210                 215                 220                 


Ser Ala Val Val Val Leu Glu Arg Ser Gly Lys Arg Val Ser Leu Glu 
225                 230                 235                 240 


Val Ala Gly Arg Val Leu Phe Glu His Trp Pro Lys Val Phe Phe Asp 
                245                 250                 255     


Pro Leu Ser Arg Lys Ala Leu Gly Ile Ala Asp Ala Arg Asn Ser His 
            260                 265                 270         


Pro Gly Leu Phe Ser Leu His Met Ala Val Lys Asp Ala Tyr Ala Arg 
        275                 280                 285             


Val Leu Lys Arg His Lys Lys Gly Ala Gly Ala Gly Ala Arg Lys Gly 
    290                 295                 300                 


Ser Gln Ala Thr Ala Arg Leu Ser Val Ile Leu Pro Lys Asp Met Pro 
305                 310                 315                 320 


Gly Leu Ile Arg Leu Ile Thr Ala Gln Lys Asp Asn Gln Asn Ile Asn 
                325                 330                 335     


Arg Gln Ile Arg Leu Gly Arg Ile Leu His Tyr Thr Ala Ser Gly Glu 
            340                 345                 350         


Trp Ser Asp Ser Thr Thr Ala Val Asp Ala Lys Trp Pro Thr Asp Ile 
        355                 360                 365             


Leu Glu Ser Pro Phe Trp Ala Ser Asp Gly Gln Ala Lys Ile Lys Arg 
    370                 375                 380                 


Ala Glu Ala Phe Val Arg Val Trp Arg His Gln Ile Ala Leu Ala Arg 
385                 390                 395                 400 


Leu Thr Leu Thr Asp Trp Ala Ser Met Arg Lys Pro Leu Ser Arg Asp 
                405                 410                 415     


Ile Leu Gly Asp Arg Ala Ala Ala Asn Leu Val Ile His Gln Asp Asn 
            420                 425                 430         


Phe Ser Ser Glu Leu Phe Asp Arg Lys Ala Ala Leu Leu Phe Gly Val 
        435                 440                 445             


Gln Ser Lys Ile Phe Ala Ala Asp Asp Ala Ser Lys Lys Glu Val Leu 
    450                 455                 460                 


Lys Cys Val Ile Glu Glu Met Ser Glu Leu Arg Asn Gln Ala Phe His 
465                 470                 475                 480 


Phe Lys Gly Leu Arg Glu Phe Leu Val Ser Ile Asp Arg Leu Ser Phe 
                485                 490                 495     


Ser Asp Leu Val Gln Lys Ser Ala Arg Gln Ile Trp Glu Ala Asp Ser 
            500                 505                 510         


Ser Arg Arg Ser His Arg Leu Lys Glu Thr Leu Arg Ala Ala His Ala 
        515                 520                 525             


Glu Val Tyr Phe Ser Ala Thr Gln Cys Glu Ala Leu Leu Arg Arg Val 
    530                 535                 540                 


Thr Thr Gln Val Asp Ser Asp Leu Pro Leu Pro Arg Phe Ser Arg Leu 
545                 550                 555                 560 


Leu Arg Arg Ala Lys Ser Cys Pro Asp Arg Ala Ala Ile Lys Leu Pro 
                565                 570                 575     


Pro Pro Ala Asn Arg Ser Asp Leu Glu Gln Pro Trp Arg Leu Cys Gln 
            580                 585                 590         


Tyr Thr Ala Leu Lys Leu Leu Tyr Glu Arg Pro Phe Arg Thr Trp Leu 
        595                 600                 605             


Glu Ala Arg Ser Ala Asp Glu Leu Asn Ala Trp Ile Gly Arg Ala Val 
    610                 615                 620                 


Gln Arg Ala Thr Asp Ala Ala His Ser Gln Asn Tyr Arg Lys Tyr Lys 
625                 630                 635                 640 


Leu Ala Gln Lys Val Ile Ser Ala Arg Ala Ser Ser Leu Pro Arg Pro 
                645                 650                 655     


Thr Lys Gly Gln Lys Ile Arg Asp Phe Phe Phe Ala Leu Ser Ser Ala 
            660                 665                 670         


Thr Ala Ser Glu Met Arg Val Gln Arg Gly Tyr Glu Ser Asp Gly Glu 
        675                 680                 685             


Lys Ala Arg Asn Gln Ala Asp Phe Ile Asp Asn Leu Leu Cys Asp Val 
    690                 695                 700                 


Met Ser Leu Ala Leu Cys Gln Phe Ile Ser Ser Glu Ala Phe Leu Trp 
705                 710                 715                 720 


Ile Leu Ile Ala Pro Val Asp Pro Tyr Leu Val Gly Lys Arg Lys Cys 
                725                 730                 735     


Gln Leu Asp Ala Phe Glu Leu Pro Ile Pro Ser Phe Glu Ala Lys Glu 
            740                 745                 750         


Trp Gln Val Ser Leu Tyr Phe Leu Leu His Leu Ile Pro Val Gly Asp 
        755                 760                 765             


Val Ala Gln Leu His His Gln Val Ala Lys Trp Glu Ile Thr Ala Gly 
    770                 775                 780                 


Arg Asp Glu Gly Ile Glu Leu Glu Asp Met Asn Arg Ile Leu Arg Leu 
785                 790                 795                 800 


Gln Thr Thr Leu Lys Leu Tyr Met Asp Met His Asp Glu Lys Phe Glu 
                805                 810                 815     


Gly Asp Ala Arg Leu Glu Gly Cys Glu Gly Phe Arg Asp Leu Phe Glu 
            820                 825                 830         


Thr Asn Ser Gly Phe Glu Gln Val Phe Pro Lys Ser Ser Ser Pro Asp 
        835                 840                 845             


Asp Asp Arg His Leu Pro Arg Arg Gly Leu Arg Glu Ile Met Arg Tyr 
    850                 855                 860                 


Gly His Leu Gln Met Val Met Gly Phe Leu Pro Lys Gln Lys Ile Ser 
865                 870                 875                 880 


Asp Gly Glu Val Ala Glu Tyr Leu Glu Thr Met Arg Ala Ser Gly Pro 
                885                 890                 895     


Asn Gly Gln Ser Glu Ile Ala Ile His Gln Ala Gln Arg Glu Glu Leu 
            900                 905                 910         


His Glu Lys Trp Ser Arg Ala Arg Pro Gln Leu Leu Ser Gly Asp Glu 
        915                 920                 925             


Tyr Arg Ala Tyr Cys Glu Val Leu Thr Lys Ile Val Lys His Arg Gln 
    930                 935                 940                 


Ala Ala Ala Arg Ile Asn Leu Thr Ala Ile Val His Phe His His Gln 
945                 950                 955                 960 


Val Met Thr Leu Leu Gly Arg Leu Ala Asp Phe Ser Gly Leu Phe Glu 
                965                 970                 975     


Arg Asp Leu Tyr Phe Val Thr Leu Ala Ile Leu Tyr Gln Tyr Gly Leu 
            980                 985                 990         


Ser Pro Gln Arg Ala Phe Glu Asp  Lys Gly Leu Gly Tyr  Leu Lys Glu 
        995                 1000                 1005             


Gly Arg  Ile Phe Lys Ala Leu  Glu Asn Leu Ile Ser  Glu His Lys 
    1010                 1015                 1020             


Gly Lys  Ile Lys Val Glu Leu  Lys His Tyr Phe Gly  Pro Glu Trp 
    1025                 1030                 1035             


Asp Ser  Trp Asp Gly Arg Arg  Gly Thr Arg Asn Arg  Leu Ala His 
    1040                 1045                 1050             


Phe Asn  Met Leu Arg Ser His  Ala Pro Arg Leu Asp  Met Thr Glu 
    1055                 1060                 1065             


Trp Val  Asn Ser Thr Arg Arg  Leu Met Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Ser Gln Ser  Ile Arg Glu Met Met  Lys Arg Asn 
    1085                 1090                 1095             


Gly Ile  Glu Leu Ser Trp Gln  Met Asp Thr Gly Gly  Lys Asn His 
    1100                 1105                 1110             


Glu Leu  Thr Ser Ala Val Val  Ser Ser Ala Ser Val  Val His Leu 
    1115                 1120                 1125             


Gly Gly  Ile Arg Leu Val Glu  Phe Ser Gly Ser Ala  Ser Asn Ser 
    1130                 1135                 1140             


Asn Lys  Thr Gln Ala Ile Thr  Glu Ala Leu His Gly  Thr Pro Tyr 
    1145                 1150                 1155             


Val Gln  Met Val Ala Ala Leu  Phe Gly Gly Lys Thr  Gln Gln Phe 
    1160                 1165                 1170             


Asp Asp  Ile Thr Gly Arg Asp  Leu Ser Asn Ile Asp  Trp Gln Ser 
    1175                 1180                 1185             


Thr Glu  Arg Lys Ala Gln Asn  Thr Gly Gly Arg Gly  Ala Met Gly 
    1190                 1195                 1200             


Thr Leu  Arg Pro Arg Arg Glu  Glu Lys Val Arg Arg  Glu 
    1205                 1210                 1215     


<210>  326
<211>  1137
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  326

Met Lys Ile Thr Lys Ile Gly Gly Ile Ser His Lys Lys Tyr Gly Glu 
1               5                   10                  15      


Lys Gly Lys Leu Ile Lys Ser Asn Glu Ile Glu Lys Asp Val Ile Glu 
            20                  25                  30          


Glu Arg Phe Asn Asp Ile Glu Lys Lys Thr Lys Glu Leu Phe Leu Lys 
        35                  40                  45              


Thr Leu Asp Ser Tyr Val Lys Asn Tyr Glu Lys Cys Glu Glu Gln Asn 
    50                  55                  60                  


Lys Glu Arg Arg Glu Lys Ala Lys Asn Tyr Phe Ser Lys Val Lys Leu 
65                  70                  75                  80  


Ile Ile Asp Asn Glu Lys Ile Thr Ile Cys Asn Glu Asn Thr Glu Lys 
                85                  90                  95      


Ile Glu Ile Glu Asp Phe Asn Glu Tyr Asp Val Arg Asn Arg Lys Tyr 
            100                 105                 110         


Phe Asn Ile Leu Asn Lys Ile Leu Asn Gly Glu Asn Cys Thr Glu Glu 
        115                 120                 125             


Asp Leu Glu Val Phe Glu Asn Asp Leu Gln Lys Lys Leu Asn Gln Ile 
    130                 135                 140                 


Gln Ser Ile Lys Asn Ser Leu Glu Glu Asn Lys Ala His Phe Lys Lys 
145                 150                 155                 160 


Glu Ser Val Asn Asn Thr Ala Asp Arg Val Lys Gly Asn Asn Lys Lys 
                165                 170                 175     


Ser Leu Phe Tyr Glu Tyr Tyr Arg Asn Ser Ser Lys His Gln Glu Tyr 
            180                 185                 190         


Val Asn Asn Ile Phe Glu Ala Phe Asp Lys Leu Tyr Ser Asn Ser His 
        195                 200                 205             


Glu Asp Ile Asn Asn Leu Phe Leu Glu Ile Thr Lys Asp Ser Asn Asp 
    210                 215                 220                 


Arg Asn Ile Arg Lys Ile Arg Glu Ala Tyr His Glu Ile Leu Asn Lys 
225                 230                 235                 240 


Asn Lys Thr Glu Phe Gly Glu Glu Leu Tyr Lys Lys Val Gln Asn Asn 
                245                 250                 255     


Ile Asn Asn Phe Asp Lys Leu Leu Glu Ile Glu Pro Glu Ile Lys Glu 
            260                 265                 270         


Leu Thr Lys Ser Gln Ile Phe Tyr Lys Tyr Tyr Ile Asp Lys Val Ser 
        275                 280                 285             


Leu Asp Gly Thr Asn Ile Lys His Cys Phe Ser His Leu Val Glu Ile 
    290                 295                 300                 


Glu Val Asn Gln Leu Leu Lys Asn Tyr Val Tyr Ser Lys Arg Ser Thr 
305                 310                 315                 320 


Asn Lys Glu Lys Leu Glu Asn Ile Phe Glu Tyr Cys Lys Leu Arg Asn 
                325                 330                 335     


Leu Val Lys Asn Lys Leu Val Asn Lys Leu Asn Ser Tyr Ile Arg Asn 
            340                 345                 350         


Cys Gly Lys Tyr Asn Gly Tyr Ile Ser Asn Asn Asp Val Val Asn Ser 
        355                 360                 365             


Glu Lys Ile Ser Glu Ile Arg Thr Lys Glu Ala Phe Leu Arg Ser Ile 
    370                 375                 380                 


Ile Gly Val Ser Ser Ser Ala Tyr Phe Ser Leu Arg Asn Ile Leu Asn 
385                 390                 395                 400 


Thr Asp Asn Thr Gln Asp Ile Thr Asn Lys Val Asp Lys Glu Val Asp 
                405                 410                 415     


Lys Leu Tyr Gln Glu Asn Lys Lys Ile Glu Leu Glu Glu Arg Leu Lys 
            420                 425                 430         


Leu Phe Phe Gly Asn Tyr Phe Asp Ile Asn Asn Gln Gln Glu Ile Lys 
        435                 440                 445             


Ala Phe Leu Met Asn Ile Asp Lys Ile Ile Ser Ser Ile Arg His Glu 
    450                 455                 460                 


Ile Ile His Phe Lys Met Glu Ala Asn Ala Gln Asn Ile Phe Asp Phe 
465                 470                 475                 480 


Asn Asn Ile Asn Leu Gly Asn Val Thr Lys Asn Ile Phe Ser Asn Glu 
                485                 490                 495     


Ile Asn Glu Glu Lys Ile Lys Phe Lys Ile Phe Lys Gln Leu Asn Ser 
            500                 505                 510         


Ala Asn Val Phe Asp Tyr Leu Ser Asn Lys Asp Ile Thr Glu Tyr Met 
        515                 520                 525             


Gly Lys Ala Val Phe Ser Phe Ile Asn Arg Asn Ile Ser Phe Val Pro 
    530                 535                 540                 


Ser Phe Thr Lys Ile Tyr Asn Arg Val Gln Asp Leu Ala Asn Ser Leu 
545                 550                 555                 560 


Glu Ile Lys Glu Trp Lys Ile Pro Asp Glu Ser Glu Gly Lys Asp Ala 
                565                 570                 575     


Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Arg Lys Phe Leu Asp Glu 
            580                 585                 590         


Phe Leu Asn Glu Lys Asn Gly Lys Phe Ile Arg Met Lys Asp Lys Val 
        595                 600                 605             


Ile Glu Leu Asn Arg Lys Gln Asn Lys Lys Thr Gly Phe Tyr Lys Leu 
    610                 615                 620                 


Glu Lys Phe Glu Lys Ile Glu Glu Thr Asn Pro Lys Lys Tyr Leu Glu 
625                 630                 635                 640 


Ile Ile Gln Ser Leu Tyr Met Ile Asn Ile Glu Glu Ile Asp Ser Glu 
                645                 650                 655     


Glu Lys Asn Ile Phe Leu Asp Phe Ile Gln Lys Ile Phe Leu Lys Gly 
            660                 665                 670         


Phe Phe Glu Phe Ile Lys Asn Asp Tyr Asn Tyr Leu Leu Lys Leu Glu 
        675                 680                 685             


Lys Val Gln Asp Lys Lys Asn Ile Phe Asp Lys Glu Met Ser Glu Tyr 
    690                 695                 700                 


Thr Ala Gly Glu Lys Ala Leu Gly Asp Met Lys Glu Ile Asn Lys Ile 
705                 710                 715                 720 


Ala Gln Lys Ile Lys Val Ala Glu Ile Asp Lys Ile Leu Asn Gln Thr 
                725                 730                 735     


Asp Lys Ile Asn Cys Phe Tyr Leu Leu Leu Lys Leu Leu Asn Tyr Lys 
            740                 745                 750         


Glu Ile Thr Glu Leu Lys Gly Asn Leu Glu Lys Tyr Gln Ile Leu Ser 
        755                 760                 765             


Lys Asn Asn Ile Tyr Glu Lys Glu Leu Met Leu Leu Asn Ile Val Asn 
    770                 775                 780                 


Leu Asp Asn Asn Lys Val Lys Ile Glu Asn Phe Lys Ile Ser Ser Glu 
785                 790                 795                 800 


Glu Ile Gly Lys Phe Ile Glu Lys Ile Ser Arg Asn Lys Lys Ile Glu 
                805                 810                 815     


Ile Phe Glu Glu Leu Arg Asn Phe Glu Lys Ile Glu Asn Thr Gly Glu 
            820                 825                 830         


Tyr Tyr Asn Val Tyr Ser Asp Asp Lys Asn Ile Lys Asn Ile Arg Asn 
        835                 840                 845             


Leu Tyr Asn Ile Lys Lys Tyr Gly Met Leu Ser Leu Leu Glu Lys Ile 
    850                 855                 860                 


Ser Glu Lys Thr Asn Tyr Cys Ile Lys Lys Lys Asp Leu Glu Glu Tyr 
865                 870                 875                 880 


Ser Glu Leu Arg Lys Gln Leu Glu Asp Glu Lys Thr Asp Phe Tyr Lys 
                885                 890                 895     


Ile Gln Lys Asp Leu His Tyr Glu Tyr Gln Lys Lys Tyr Lys Asn Phe 
            900                 905                 910         


Ser Lys Lys Asn Asn Thr Glu Asp Tyr Glu Lys Tyr Lys Lys Ser Ile 
        915                 920                 925             


Glu Asn Ile Glu Lys Tyr Val His Leu Lys Asn Lys Ile Glu Phe Asn 
    930                 935                 940                 


Glu Leu Asn Leu Phe Gln Ser Leu Leu Leu Lys Ile Leu His Arg Leu 
945                 950                 955                 960 


Val Gly Phe Thr Ser Ile Trp Glu Arg Asp Leu Arg Phe Arg Leu Ile 
                965                 970                 975     


Gly Glu Phe Pro Asp Glu Leu Asp Ile Ile Glu Ile Phe Asn His Asn 
            980                 985                 990         


Asn Arg Asn Asn Ser Val Tyr Lys  Ser Gly Gln Ile Cys  Pro Lys Tyr 
        995                 1000                 1005             


Glu Gln  Phe Ile Ser Thr His  Ile Glu Tyr Gln Asn  Asn Asn Lys 
    1010                 1015                 1020             


Met Lys  Asn Ile Lys Phe Asp  Asp Asn Asn Phe Ile  Arg Asn Tyr 
    1025                 1030                 1035             


Ile Ala  His Phe Asn Tyr Leu  Pro Thr Pro Lys Tyr  Ser Ile Leu 
    1040                 1045                 1050             


Lys Met  Ile Glu Lys Leu Arg  Glu Leu Leu Asp Tyr  Asp Arg Lys 
    1055                 1060                 1065             


Leu Lys  Asn Ala Val Met Lys  Ser Ile Lys Asp Ile  Leu Glu Glu 
    1070                 1075                 1080             


Tyr Gly  Phe Lys Ala Glu Phe  Val Ile Asn Ser Asp  Lys Glu Ile 
    1085                 1090                 1095             


Ile Leu  Asn Ser Ile Lys Ser  Thr Glu Ile Ile His  Leu Lys Lys 
    1100                 1105                 1110             


Asn Asp  Leu Lys Ser His Arg  Asn Ser Glu Asp Leu  Cys Lys Leu 
    1115                 1120                 1125             


Val Lys  Thr Met Phe Glu Tyr  Lys Lys 
    1130                 1135         


<210>  327
<211>  1204
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  327

Met Lys Val Thr Lys Ile Asp Gly Ile Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Arg Tyr Thr Gly Asn Phe Asn Ile Lys Asn Glu 
            20                  25                  30          


Met Lys Glu Arg Leu Glu Lys Leu Lys Glu Leu Lys Leu Ser Asn Tyr 
        35                  40                  45              


Ile Lys Asn Pro Glu Asn Val Lys Asn Lys Asp Lys Asn Lys Glu Lys 
    50                  55                  60                  


Glu Thr Lys Ser Arg Arg Glu Asn Leu Lys Lys Tyr Phe Ser Glu Ile 
65                  70                  75                  80  


Ile Leu Arg Lys Lys Glu Glu Lys Tyr Leu Leu Lys Lys Thr Arg Lys 
                85                  90                  95      


Phe Lys Asn Ile Thr Glu Glu Ile Asn Tyr Asp Asp Ile Lys Lys Arg 
            100                 105                 110         


Glu Asn Gln Gln Lys Ile Phe Asp Val Leu Lys Glu Leu Leu Glu Gln 
        115                 120                 125             


Arg Ile Asn Glu Asn Asp Lys Glu Glu Ile Leu Asn Phe Asp Ser Val 
    130                 135                 140                 


Lys Leu Lys Glu Ala Phe Gly Glu Asp Phe Ile Lys Lys Glu Ser Lys 
145                 150                 155                 160 


Ile Lys Ala Ile Glu Glu Ser Leu Glu Lys Asn Arg Ala Asp Tyr Arg 
                165                 170                 175     


Lys Gly Phe Val Glu Leu Glu Asn Gly Lys Tyr Glu Asp Val Lys Gly 
            180                 185                 190         


Gln Asn Lys Arg Ser Leu Val Phe Glu Tyr Tyr Lys Asn Pro Glu Asn 
        195                 200                 205             


Arg Glu Lys Phe Lys Glu Asn Ile Lys Tyr Ala Phe Glu Asn Leu Tyr 
    210                 215                 220                 


Ile Glu Glu Asn Ile Lys Asn Leu Tyr Ser Glu Ile Glu Glu Ile Phe 
225                 230                 235                 240 


Glu Lys Val His Leu Lys Ser Lys Val Arg Asp Phe Tyr Gln Asn Gly 
                245                 250                 255     


Ile Ile Gly Glu Ser Glu Phe Ser Glu Lys Asp Glu Glu Gly Ile Ser 
            260                 265                 270         


Ile Leu Tyr Lys Gln Ile Ile Asn Ser Val Glu Lys Lys Glu Lys Phe 
        275                 280                 285             


Val Glu Phe Leu Gln Lys Val Lys Ile Lys Asp Leu Thr Arg Ser Gln 
    290                 295                 300                 


Ile Phe Tyr Lys Tyr Phe Leu Glu Asn Glu Glu Leu Asn Asp Glu Asn 
305                 310                 315                 320 


Ile Lys Tyr Val Phe Ser Tyr Phe Val Glu Ile Glu Val Asn Lys Leu 
                325                 330                 335     


Leu Lys Glu Asn Val Tyr Lys Thr Lys Lys Phe Asn Glu Gly Asn Lys 
            340                 345                 350         


Tyr Arg Val Lys Asn Ile Phe Asn Tyr Asp Lys Leu Lys Asn Leu Val 
        355                 360                 365             


Val Tyr Lys Leu Glu Asn Lys Leu Asn Asn Tyr Ile Arg Asn Cys Gly 
    370                 375                 380                 


Lys Tyr Asn Tyr His Met Glu Asn Gly Cys Val Ala Thr Ser Asp Thr 
385                 390                 395                 400 


Asn Met Lys Asn Arg Gln Thr Glu Ala Phe Leu Arg Ser Ile Leu Gly 
                405                 410                 415     


Val Ser Ser Phe Gly Tyr Phe Ser Leu Arg Asn Ile Leu Gly Val Asn 
            420                 425                 430         


Asp Asn Asp Phe Tyr Glu Met Glu Glu Glu Leu Thr Glu Asp Glu Arg 
        435                 440                 445             


Lys Asn Glu Asn Phe Ile Leu Lys Lys Ala Lys Glu Asp Ile Thr Ser 
    450                 455                 460                 


Lys Asn Ile Phe Glu Lys Val Val Asp Lys Ser Phe Glu Lys Lys Gly 
465                 470                 475                 480 


Ile Tyr Gln Ile Lys Glu Asn Leu Lys Met Phe Tyr Gly Asn Ser Phe 
                485                 490                 495     


Asp Lys Val Asp Lys Asp Glu Leu Lys Lys Phe Phe Val Asn Met Leu 
            500                 505                 510         


Glu Ala Ile Thr Ser Val Arg His Arg Ile Val His Tyr Asn Ile Asn 
        515                 520                 525             


Thr Asn Ser Glu Asn Ile Phe Asp Phe Ser Asn Ile Glu Val Ser Lys 
    530                 535                 540                 


Leu Leu Lys Asn Ile Phe Glu Lys Glu Ile Asp Thr Arg Glu Leu Lys 
545                 550                 555                 560 


Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Gly Val Phe Asp Tyr Trp 
                565                 570                 575     


Glu Ser Trp Val Ile Lys Lys Tyr Leu Glu Asn Val Lys Phe Glu Phe 
            580                 585                 590         


Val Asn Lys Asn Val Pro Phe Val Pro Ser Phe Lys Lys Leu Tyr Asp 
        595                 600                 605             


Arg Ile Asp Asn Leu Lys Gly Trp Asn Ala Leu Lys Leu Gly Asn Asn 
    610                 615                 620                 


Ile Asn Ile Pro Lys Arg Lys Glu Ala Lys Asp Ser Gln Ile Tyr Leu 
625                 630                 635                 640 


Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Val Glu Lys Phe Val Asn Asp 
                645                 650                 655     


Asn Lys Asn Phe Glu Lys Ile Val Lys Glu Ile Ile Glu Ile Asn Arg 
            660                 665                 670         


Gly Ala Gly Thr Asn Lys Lys Thr Gly Phe Tyr Lys Leu Glu Lys Phe 
        675                 680                 685             


Glu Thr Leu Lys Ala Asn Thr Pro Ile Glu Tyr Leu Glu Glu Leu Gln 
    690                 695                 700                 


Ser Leu His Lys Ile Ser Tyr Asp Lys Glu Lys Ile Glu Glu Asp Lys 
705                 710                 715                 720 


Asp Ile Tyr Val Asp Phe Val Gln Lys Ile Phe Leu Lys Gly Phe Val 
                725                 730                 735     


Asn Tyr Leu Lys Lys Leu Asp Ser Leu Lys Ser Leu Asn Leu Leu Asn 
            740                 745                 750         


Leu Arg Lys Asp Glu Thr Ile Thr Asp Lys Lys Ser Val His Asp Glu 
        755                 760                 765             


Lys Leu Lys Leu Trp Glu Asn Ser Gly Ser Asn Leu Ser Lys Met Pro 
    770                 775                 780                 


Glu Glu Ile Tyr Glu Tyr Val Lys Lys Ile Lys Ile Ser Asn Ile Asn 
785                 790                 795                 800 


Tyr Asn Asp Arg Met Ser Ile Phe Tyr Leu Leu Leu Lys Leu Ile Asp 
                805                 810                 815     


Tyr Arg Glu Leu Thr Asn Leu Arg Gly Asn Leu Glu Lys Tyr Glu Ser 
            820                 825                 830         


Met Asn Lys Asn Glu Ile Tyr Ser Glu Glu Leu Thr Ile Ile Asn Leu 
        835                 840                 845             


Val Asn Leu Asp Asn Asn Lys Val Arg Thr Asn Phe Ser Leu Glu Ala 
    850                 855                 860                 


Glu Asp Ile Gly Lys Phe Leu Lys Ser Ser Ile Pro Ile Lys Asn Val 
865                 870                 875                 880 


Ala Gln Leu Asn Asn Phe Ser Lys Ile Phe Ala Asp Gly Glu Asn Val 
                885                 890                 895     


Ile Lys His Arg Ser Phe Tyr Asn Ile Lys Lys Tyr Gly Ile Leu Asp 
            900                 905                 910         


Leu Leu Glu Lys Ile Val Ala Lys Ala Asp Leu Lys Ile Ala Lys Glu 
        915                 920                 925             


Glu Ile Lys Lys Tyr Glu Asn Leu Gln Lys Glu Leu Glu Lys Asn Asp 
    930                 935                 940                 


Phe Tyr Lys Ile Gln Glu Lys Ile His Arg Lys Tyr Asn Gln Lys Pro 
945                 950                 955                 960 


Asn Leu Ile Leu Arg Thr Glu Asn Lys Lys Asp Phe Asn Asp Tyr Lys 
                965                 970                 975     


Lys Ala Ile Glu Asn Ile Gln Asn Tyr Thr Gln Leu Lys Asn Lys Ile 
            980                 985                 990         


Glu Phe Asn Asp Leu Asn Leu Leu  Gln Ser Leu Leu Phe  Arg Ile Leu 
        995                 1000                 1005             


His Arg  Leu Ala Gly Tyr Thr  Ser Leu Trp Glu Arg  Asp Leu Gln 
    1010                 1015                 1020             


Phe Lys  Leu Lys Gly Glu Phe  Pro Glu Asp Lys Tyr  Ile Asp Glu 
    1025                 1030                 1035             


Ile Phe  Asn Phe Asp Asn Ser  Lys Asn Lys Ile Tyr  Asn Glu Lys 
    1040                 1045                 1050             


Asn Lys  Arg Gly Gly Ser Ile  Val Ser Lys Tyr Gly  Tyr Phe Leu 
    1055                 1060                 1065             


Ala Glu  Lys Asp Gly Glu Ile  Gln Glu Ser Arg Ala  Arg Asp Lys 
    1070                 1075                 1080             


Lys Lys  Lys Lys Ile Ile Lys  Lys Glu Gly Leu Glu  Ile Arg Asn 
    1085                 1090                 1095             


Tyr Ile  Ala His Phe Asn Tyr  Ile Pro Asp Ala Glu  Lys Ser Ile 
    1100                 1105                 1110             


Leu Glu  Met Leu Glu Glu Leu  Arg Glu Leu Leu Lys  Tyr Asp Arg 
    1115                 1120                 1125             


Lys Leu  Lys Asn Ala Val Met  Lys Ser Ile Lys Asp  Ile Phe Lys 
    1130                 1135                 1140             


Glu Tyr  Gly Phe Ile Val Glu  Phe Thr Ile Ser His  Thr Lys Asn 
    1145                 1150                 1155             


Gly Lys  Lys Ile Lys Val Cys  Ser Val Lys Ser Glu  Lys Ile Lys 
    1160                 1165                 1170             


His Leu  Lys Asn Asn Glu Leu  Ile Thr Thr Arg Asn  Ser Glu Asp 
    1175                 1180                 1185             


Leu Cys  Glu Leu Val Lys Ile  Met Leu Glu Tyr Lys  Glu Leu Gln 
    1190                 1195                 1200             


Lys 
    


<210>  328
<211>  1210
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  328

Met Lys Ile Thr Lys Arg Lys Trp Glu Asp Val Pro Pro Leu Phe Phe 
1               5                   10                  15      


His Arg Asp Lys Asp Ser Gly Arg Leu Ile Arg Gln Asp Asp Arg Glu 
            20                  25                  30          


His Asp Tyr Thr Asp Glu Leu Phe Arg Lys Thr Thr Val Asp Ser Ile 
        35                  40                  45              


Phe Ile Arg Ser Leu Gln Asn Arg Leu Leu Arg Ser Gln Asp Lys Glu 
    50                  55                  60                  


Gly Asn Lys Ile Gly Arg Asn Glu Ile Thr Glu Leu Val Glu Asn Leu 
65                  70                  75                  80  


Cys Lys Gly Ala Glu Ile Gln Lys Ser Ile Asp Glu Ile Lys Asp Ser 
                85                  90                  95      


Lys Ser Asn Val Lys Ala Leu Cys Asp Lys Thr Leu Thr Asp Tyr Gly 
            100                 105                 110         


Lys Ser Phe Ala Ala Glu Glu Gly Arg Thr Thr Leu Tyr Glu Ala Ile 
        115                 120                 125             


Leu Asn Leu Ala Lys Gly Asn Ala Ile Gln Lys Ala Met Ala Glu Ala 
    130                 135                 140                 


Glu Leu Lys Gln Ile His Glu Ala Leu Lys Lys Glu Lys Glu Asp Arg 
145                 150                 155                 160 


Ile Asn Arg Val Gln Asn Ser Ile Lys Asn Asn Lys Ile Pro Leu Lys 
                165                 170                 175     


Val Asn Glu Asp Gly Thr Ile Ser Ala Asn Asn Asp Arg Ala Ser Trp 
            180                 185                 190         


Leu Leu Glu Leu Leu Lys Pro Val Ala Ser Glu His Asp Lys Gly Asp 
        195                 200                 205             


Arg Tyr Pro Val Leu Thr Glu Met Glu Gly Ile Val Ser Phe Asp Lys 
    210                 215                 220                 


Leu Cys Glu Glu Val Arg Asn Lys Ile His Gly Arg Lys Gly Arg Thr 
225                 230                 235                 240 


Arg Ser Ile Ala Met Ser Val Asp Glu Ala Val Lys Glu Tyr Leu Lys 
                245                 250                 255     


Glu Leu Trp Lys Lys His Ala Asp Arg His Arg Asp Met Arg Tyr Tyr 
            260                 265                 270         


Phe Gln Ala Val Lys Glu Tyr Phe Lys Glu Asn Phe Pro Ile Arg Thr 
        275                 280                 285             


Lys Gln Lys Gly Ala Gly Ile Arg Gln Ser Leu Leu Lys Glu Asp Thr 
    290                 295                 300                 


Val Val Ala Arg Leu Leu Asp Pro Lys His Met Ala Lys Ala Val Arg 
305                 310                 315                 320 


Arg Lys Leu Ile Asn Gln Ser Ile Gln Met His Ile Leu Tyr Gly Lys 
                325                 330                 335     


Leu Tyr Glu Tyr Cys Cys Arg Glu Asp Arg Asn Leu Pro Ala Asn Ser 
            340                 345                 350         


Glu Thr Leu Gln Leu Ile Gln Val Leu Glu Ala Phe Lys Lys Gln Leu 
        355                 360                 365             


Met Thr Ala Val Leu Trp Ser Val Ser Arg Leu Cys Tyr Phe Tyr Glu 
    370                 375                 380                 


Phe Tyr Ser Gly Asp Ile Leu Leu Ala Glu Glu Tyr Arg Arg Asp Phe 
385                 390                 395                 400 


Leu Asn Gln Lys Asn Asp His Lys Asp Ile Gln Ala Cys Lys Glu Lys 
                405                 410                 415     


Leu Gln Asp Phe Phe Pro Leu Ala Glu Leu Gln Glu Lys Ile Arg Glu 
            420                 425                 430         


Cys Ala Asp Lys Asp Ile Asn Asn Ile Lys Asp Lys Ile Thr Asn Asp 
        435                 440                 445             


Val Leu Ala Cys Asn Asn Leu Leu Glu Glu Cys Val Phe Cys Ile Ser 
    450                 455                 460                 


Lys Leu Arg Asn Asn Ile Phe His Tyr Lys Asn Leu Ser Phe Thr Gln 
465                 470                 475                 480 


Ala Leu Lys His Ile Ala Asn Glu Asn Lys Glu Glu Asp Ile Pro Ile 
                485                 490                 495     


Ile Leu Arg Leu Tyr Lys Gln Asp Cys Glu Asn Val Asn Lys Ala Phe 
            500                 505                 510         


Ala Asn Arg Ile Ser Ser Met Asn Leu Pro Leu Tyr Tyr Ser Thr Glu 
        515                 520                 525             


Phe Leu Leu Arg Ile Phe Lys Lys Gln Gly Ala Glu Leu Ser Leu Tyr 
    530                 535                 540                 


Ser Thr Lys Asn Gln Met Thr Pro Ser Phe Lys Arg Val Tyr Glu Arg 
545                 550                 555                 560 


Gly Lys Asn Leu Arg Leu Glu Tyr Glu Arg Glu Pro Met Arg Ser Asn 
                565                 570                 575     


Ile Ala Asn Glu Tyr Asp Lys Asp Pro Gln Ser Asp Tyr Trp Met Arg 
            580                 585                 590         


Trp Phe Ser Gln Phe Ala Thr Gly Thr Val Asp Thr Asn Ala Gly Ile 
        595                 600                 605             


Lys Gly Glu Met Glu Asp Tyr Pro His Ala Ser Val Asn Leu Gly Ile 
    610                 615                 620                 


Glu Ile Glu Ala Gly Thr Asn Ile Asp Ala Gln Arg Ala Met Arg Asn 
625                 630                 635                 640 


Leu Leu Gln Leu Ile Tyr Lys His His Phe Leu Pro Glu Val Gln Lys 
                645                 650                 655     


Asp Glu Thr Val Val Thr Asp Val Ile Pro Lys Val Leu Glu Arg Asn 
            660                 665                 670         


Arg Lys Leu Ser Glu Val Arg Asn Arg Ser Asp Lys Thr Tyr Gly Tyr 
        675                 680                 685             


Lys Glu Ile Glu Glu Leu Cys Lys Lys Asn Lys Gly Lys Lys Asp Ser 
    690                 695                 700                 


Leu Ser Glu Leu Met Lys Asp Leu Gln Arg Lys Val Ser Glu Thr Glu 
705                 710                 715                 720 


Lys Glu Lys Arg Glu Leu Ala Arg Glu Lys Thr Asp Tyr Ala Gln Arg 
                725                 730                 735     


Phe Ile Leu Asp Ile Phe Ala Glu Ala Phe Cys Asn Phe Met Asp Glu 
            740                 745                 750         


Arg Tyr Glu Asp Glu Tyr Gln Glu Ile Met Ser Pro Ile Lys Asn Glu 
        755                 760                 765             


Glu Glu Ala Lys Lys Trp Thr Glu Met Phe Thr Asp Lys Ala Asp Lys 
    770                 775                 780                 


Asp Asn Lys Asp Lys Leu Leu Val Leu Lys Thr Ser Phe Asp Lys Asp 
785                 790                 795                 800 


Asn Val Glu Lys Tyr Leu Leu Val Leu Tyr Pro Leu Met Arg Leu Leu 
                805                 810                 815     


Asp Asp Lys Glu Leu Ser Glu Leu Gln Gln Gln Met Leu Arg Phe Arg 
            820                 825                 830         


Ala Ser Val Ser Gly Trp Gln Gly Gly Thr Asp Phe Ser Glu Asp Ile 
        835                 840                 845             


Ala Met Ala Glu Lys Ile Glu Glu Leu Ala Glu Leu Val Lys Leu Thr 
    850                 855                 860                 


Glu Pro Glu Ser Gln Tyr Ala Glu Glu Ala Trp Lys Asn Arg Ala Ile 
865                 870                 875                 880 


Gly Val Phe Glu Gln Phe Val Glu Gly Lys Met Ala Glu Tyr Gly Thr 
                885                 890                 895     


Phe Tyr Ile Gln Asn Asp Ser Leu Thr Gln Val Pro Arg Gly Asn Met 
            900                 905                 910         


Arg Lys Leu Leu Arg Ser Gly Val Ile Gly Val Tyr Asn Lys Val Leu 
        915                 920                 925             


Ala Ser Cys Lys Gln Ala Thr Lys Ala Asp Tyr Gly Ala Tyr Ser Gly 
    930                 935                 940                 


Asp His Trp Ser Ile Glu Asp Pro Asp Gly Asn Pro Ile Lys Ser Ala 
945                 950                 955                 960 


Glu Gln Ala Gln Ala Leu Leu Gln Arg Leu His Lys Lys Tyr Thr Glu 
                965                 970                 975     


Ser Pro Ser Gln Phe Ser Asp Asp Asp His Lys Leu Tyr Asp Lys Thr 
            980                 985                 990         


Leu Arg Gln Leu Asp Ala Tyr Asn  Arg Ala Met Lys Asn  Leu Ser Phe 
        995                 1000                 1005             


Gly Ser  Leu Tyr Glu Ile Cys  Arg Ile His Met Glu  Thr Leu Ser 
    1010                 1015                 1020             


Arg Trp  Val Gly Phe Val Gln  Asp Trp Glu Arg Asp  Met Tyr Phe 
    1025                 1030                 1035             


Leu Leu  Leu Ala Trp Thr Lys  Gln Gly Lys Leu Leu  Asn Val Thr 
    1040                 1045                 1050             


Glu Thr  Asp Val Ile Glu Ile  Phe Glu Lys Gly Ser  Val Ile Tyr 
    1055                 1060                 1065             


Lys Met  Asn Lys Lys Leu Lys  Asn Gly Asp Arg Tyr  Ala Phe Thr 
    1070                 1075                 1080             


Ser Ile  Tyr Arg Asn Asn Asn  Asp Glu Lys Leu Glu  Phe Leu Gln 
    1085                 1090                 1095             


Ile Arg  Asn Phe Ile Ala His  Leu His Leu Leu Arg  Lys Ser Glu 
    1100                 1105                 1110             


Trp Lys  Gly Asp Lys Lys Ala  Gly Tyr Ser Val Ile  Glu Asp Tyr 
    1115                 1120                 1125             


Ile Asn  Lys Leu Arg Phe Leu  Leu Ser Tyr Asp Gln  Lys Arg Met 
    1130                 1135                 1140             


Asn Ala  Val Thr Lys Ala Met  Gln Gln Ile Phe Glu  Lys His Lys 
    1145                 1150                 1155             


Val Ile  Val Lys Phe Met Val  Glu Lys Gly Gly Met  Leu Lys Val 
    1160                 1165                 1170             


Lys Asp  Val Lys Pro Gly Ile  Ile Glu His Leu Lys  Gln Thr Lys 
    1175                 1180                 1185             


Arg Ile  Glu Ile Pro Cys His  Gly Glu Arg Phe Thr  Asp Ser Leu 
    1190                 1195                 1200             


Leu Val  Leu Met Lys Tyr Gln  
    1205                 1210 


<210>  329
<211>  1396
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  329

Met Ala Lys His Leu Arg Pro Ile Ser Glu Ser Tyr Thr Asp Phe Arg 
1               5                   10                  15      


Glu Pro Glu Lys Asp Arg Arg Leu Gly Arg Gly Leu His His Asp His 
            20                  25                  30          


Glu Gly Asp Gln Ile Arg Pro Ala Ala Leu Pro Gly Tyr Leu Ser Ala 
        35                  40                  45              


Asn Pro Lys Ala Leu Leu Arg Gln Thr Ile Ala Ile Leu Asp Lys Val 
    50                  55                  60                  


Val Lys Lys Arg Asn Arg Leu Ser Ala Met His Pro Glu Ala Tyr Arg 
65                  70                  75                  80  


Asp Arg Val Tyr Leu Ala Glu Ala Leu Trp Met Arg Leu Ile Ser Arg 
                85                  90                  95      


Ile Arg Glu Val Glu Lys Ile Asp Glu Ala Glu Ile Ser Glu Leu Arg 
            100                 105                 110         


Arg Leu Trp Asn Ala Lys Ser His Pro Tyr Ala Met Tyr Glu Val Val 
        115                 120                 125             


Pro Ser Gly Pro Leu Asn Asp Arg Asn Gly Gln Ala Ile Gln Lys Tyr 
    130                 135                 140                 


Arg Asp Ala Asp Gly Pro Glu Asp Pro Val Ile Ala Arg Thr Asp Phe 
145                 150                 155                 160 


Glu Gly Val Trp His Gly Arg Phe Trp Gln Glu Asp Pro Gly Arg Val 
                165                 170                 175     


Asp Tyr Gly Ala Ile Ala Asp Arg Ile Ile Ala His Leu Phe Asp Gln 
            180                 185                 190         


Glu Ile Val Ile Gly Gly Gly Pro Arg Arg Ile Gly Ser Val Ser Val 
        195                 200                 205             


Pro Glu Gly Asp Pro Asn Gly Thr Pro Gly Pro Glu Thr Ala Arg Gly 
    210                 215                 220                 


Leu Ile Val Ala Arg Gly Glu Ala Ile Ser Arg Ser Ala Ser Asp Pro 
225                 230                 235                 240 


Arg Thr Pro Ser Gly Lys Leu Gln Ala Gln Ala Thr Trp Thr Ile Cys 
                245                 250                 255     


Ala Glu Ala Arg Tyr Phe Gly Asp Asp Gly Lys Gly Gly Ser Asp Ile 
            260                 265                 270         


Ala Lys Ala Ile Phe Glu Glu Leu Glu Lys Pro Glu Asn His Ala Gly 
        275                 280                 285             


Pro Ile Tyr Pro Ser Trp Phe Gly Ser Arg Leu Phe Asp His Phe Gly 
    290                 295                 300                 


Ser Phe Lys Lys Ser Leu Pro Leu Glu Arg Lys Asp Pro Phe Lys Asp 
305                 310                 315                 320 


Gln Ile Trp Ala Leu His Asn Ala Val Arg Gln Tyr Tyr Gln Arg Leu 
                325                 330                 335     


Ala Lys Ser Asp Arg Phe Arg Ile Ala Leu Arg Lys Ala Gln Ala Asp 
            340                 345                 350         


Val Pro Asp Lys Ser Glu Leu Leu Ser Leu Leu Pro Lys Asp Arg Gln 
        355                 360                 365             


His Leu Leu Leu Val Leu Gly Gly Lys Lys Arg Asn Ala Glu Met Ser 
    370                 375                 380                 


Glu Phe Ile Arg Leu Gly Lys Leu Phe Val His Ala Ser Asp Ala Leu 
385                 390                 395                 400 


His Asp Phe Arg Glu Asp Asp Pro Ala Ala Leu Glu Ala Phe Glu Lys 
                405                 410                 415     


Arg Met Thr Phe Leu Ala Thr Ser Ile Gly Gln Ser Glu Ile Lys Gln 
            420                 425                 430         


Ile Glu Thr Phe Ala Arg Thr Trp Arg Ser Ala Val Gly Leu Thr Leu 
        435                 440                 445             


Arg Thr Leu Lys Gly Leu Ala Asp Pro Met Ala Asn Arg Gly Ser Pro 
    450                 455                 460                 


Arg Asn Arg Asp Ile Ser Thr Lys Glu Val Met Ile Asp Ala Phe Lys 
465                 470                 475                 480 


Gln Phe Asp Gln Arg His Phe Glu Arg His Ile Pro Ile Ile Phe Gly 
                485                 490                 495     


Leu Lys Asn Leu Lys Gly Gly Asp Cys Pro Ser Arg Ala Ser Ile Phe 
            500                 505                 510         


Thr Gly Asn Lys His Lys Phe Thr Gly Asn Lys His Lys Ser Gln Gln 
        515                 520                 525             


Ala Glu Leu Leu Trp Ala Met Met Cys Val Val Ser Thr Val Arg Asn 
    530                 535                 540                 


Arg Thr Asn His Phe Asn Val Arg Arg Ala Leu Ile Arg Leu Leu Glu 
545                 550                 555                 560 


Gly Gly Ile Val His Pro Ile Pro Gly Asp Pro Ser Lys Leu Asn Val 
                565                 570                 575     


Ala Asn Arg Lys Pro Gln Gln Val Ser Pro Ala Ala Leu Asp Ala Phe 
            580                 585                 590         


Lys Glu Leu Leu Glu Phe Asp Leu Ala Ile Gln Lys Asp Ala Val Arg 
        595                 600                 605             


Thr Ala Leu Glu Gln Ala Lys Ala Asp Glu Phe Val Glu Met Asp Asn 
    610                 615                 620                 


Leu Lys His Leu Val Ala His Leu Ala Gly Thr Asp Asp Ile Thr Ala 
625                 630                 635                 640 


Leu Asn Leu Pro Arg Phe Ala Ala Val Met Asp Lys Val Arg Arg Leu 
                645                 650                 655     


Ala Asp Asn Asn Asp Val Asp Leu Ala Pro Gly Leu Val Thr Leu Gln 
            660                 665                 670         


Lys Ser Leu Pro Pro Lys Asp Asp Gln Lys Glu Ser Asp Ala Ala Arg 
        675                 680                 685             


Cys Arg Tyr Arg Leu Leu Leu Glu Leu Tyr Gln Ser Gly Phe Arg Gly 
    690                 695                 700                 


Trp Leu Ser Gly Ile Gln Ser Asp Ala Glu Gly Asn Arg Glu Leu Cys 
705                 710                 715                 720 


His Trp Ala Val Gln Gln Val Gly Arg Ser Lys Asp Ala Arg Lys Thr 
                725                 730                 735     


Lys Tyr Asp Ala Arg Thr Lys Arg Tyr Tyr Arg Ser Pro Ile Ser Leu 
            740                 745                 750         


Ile Asp Asp Leu Gly Leu Asp Arg Tyr Asp Asp Ile Ser Ala Leu Leu 
        755                 760                 765             


Asp Ala Leu Ala Ala Gln Ser Thr Arg Glu Gln Gly Gln Asp Leu Lys 
    770                 775                 780                 


Tyr Thr Pro Asp Ala Arg Val Gln Arg Gln Gly Ala Asn Arg Ile Glu 
785                 790                 795                 800 


Glu Phe Arg Gln Glu Leu Phe Ala His Ile Phe Ala Lys Tyr Leu Gly 
                805                 810                 815     


Lys Pro Gly Pro Glu Asp Pro Asp Phe Gly Trp Ile Gly Glu Ile Asp 
            820                 825                 830         


Thr Lys Arg Asp Cys Cys Asp Leu Gly Glu Val Leu Lys Ser Phe Gln 
        835                 840                 845             


Pro Pro Glu Gln Ala Phe Arg Ala Asp Trp His Ser Gln Phe Tyr Ala 
    850                 855                 860                 


Trp Leu Tyr Met Val Pro Pro Ile Glu Ala Ser Arg Leu Arg His Gln 
865                 870                 875                 880 


Met Arg Lys Ser Ala Ser Met Asp Gly Lys Trp Ser Glu Thr Leu Glu 
                885                 890                 895     


Leu Ser Cys Gly Glu Arg Lys Glu Arg Asp Glu Arg Ala Gln Gly Ile 
            900                 905                 910         


Leu Ala Asp Met Asp Arg Leu Phe Ser Leu Tyr Thr Lys Val Gln Ala 
        915                 920                 925             


Ala Gly Phe Ser Gly Gln Glu His Glu Gly Ala Leu Glu Glu Lys Gly 
    930                 935                 940                 


Leu Phe Tyr Gln Asp Ala Ser Phe Phe Lys Glu Val Tyr Gln Glu Glu 
945                 950                 955                 960 


Gly Thr Ala Asn Tyr His Thr Thr Phe Pro Gly Thr Arg Ser Gly Leu 
                965                 970                 975     


Arg Gln Leu Val Arg Tyr Ala His Leu Pro Pro Leu Thr Gly Ile Phe 
            980                 985                 990         


Glu Lys His Lys Val Thr Ala Asp  Glu Val Lys Ser Phe  Ala Gly Leu 
        995                 1000                 1005             


His Asn  Glu Lys Arg Arg Asp  Pro Asp Lys Ile Asn  Cys Val Lys 
    1010                 1015                 1020             


Gln Arg  Glu Gly Phe Arg Gly  Glu Ile Leu Gln Ser  Ile Lys Asp 
    1025                 1030                 1035             


Ile Pro  Lys Pro Lys Asp Lys  Ser Tyr Ser Lys Phe  Leu Ser Asp 
    1040                 1045                 1050             


Leu Glu  Glu Lys Cys Arg Asn  Tyr Gln Thr Val Ala  Thr Ala Ala 
    1055                 1060                 1065             


Ala Ile  His Asn Phe Gln Ala  Asn Gly Ala Arg Leu  Asn Asp His 
    1070                 1075                 1080             


Val Arg  Leu His Gln Ile Val  Met Arg Val Leu Thr  Arg Leu Thr 
    1085                 1090                 1095             


Asp Tyr  Ala Leu Ile Trp Glu  Arg Asp Cys Leu Phe  Ala Phe Val 
    1100                 1105                 1110             


Gly Met  Leu Tyr Lys Glu Thr  Gly Gly Thr Gly Leu  Lys Pro Ala 
    1115                 1120                 1125             


Phe Gly  Pro Gly Val Arg Lys  Asn Ala Leu Pro Gln  Ile Gly Ile 
    1130                 1135                 1140             


Leu Val  Thr Ala Pro Asp Leu  Leu Arg Arg Ala Glu  Thr Glu Ser 
    1145                 1150                 1155             


Asp His  Val Phe Ile Pro Tyr  Leu Asp Pro Glu Thr  Gly Phe Asp 
    1160                 1165                 1170             


Ala Pro  Lys Phe Glu Asp Arg  Cys Lys Leu Leu Ser  Glu Val His 
    1175                 1180                 1185             


Cys Gln  Lys Phe Gln Leu His  Phe Ile Asp Ala Gly  Glu Arg Pro 
    1190                 1195                 1200             


Ser Asp  Gln Met Leu Arg Ser  Asn Glu Lys Pro Gly  Gly Tyr Asp 
    1205                 1210                 1215             


Ala Cys  Lys Thr Phe Lys Arg  Gly Thr Arg Lys Gln  Asp Ile Arg 
    1220                 1225                 1230             


Asn Asp  Leu Ala His Gln Asn  Ile Leu Asp His Pro  Gly Arg Arg 
    1235                 1240                 1245             


Gly Leu  Asn Leu Thr Tyr Val  Val Asn Ala Val Arg  Ser Leu Val 
    1250                 1255                 1260             


Ser Tyr  Asp Arg Lys Leu Lys  Asn Ala Val Pro Lys  Ser Ile Lys 
    1265                 1270                 1275             


Arg Ile  Leu Gly Glu Glu Gly  Leu Ile Ile Glu Trp  Gln Met Lys 
    1280                 1285                 1290             


Asp Asp  Arg Leu Lys Lys Pro  Thr Ile Tyr Pro Asp  Val Glu Thr 
    1295                 1300                 1305             


His Leu  Thr Met Val Pro Pro  His Met Met Ser Ala  Pro Val Ser 
    1310                 1315                 1320             


Phe Thr  Leu Pro Arg Ala Ser  Val Arg Leu Val Ser  Met Thr Arg 
    1325                 1330                 1335             


Ala Met  Phe Asp Phe Gly Gly  Ser Gly Tyr Gly Asp  Glu Val Val 
    1340                 1345                 1350             


Leu Ala  Gly Lys Thr Val Lys  Gln Ala Val Tyr Pro  Asp Ala Phe 
    1355                 1360                 1365             


Thr Ala  Arg Phe Pro Gln Thr  Pro Glu Thr Leu Lys  Lys Glu Thr 
    1370                 1375                 1380             


Arg Leu  Val Phe Thr Ser Glu  Lys Glu Gln Ile Ser  Asp 
    1385                 1390                 1395     


<210>  330
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  330

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Thr Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asn Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Lys Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Val 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Lys Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Asn Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Tyr Ile Tyr Trp 
                565                 570                 575     


Lys Ile Pro Lys Ala Asn Asp Asn Asn Lys Thr Lys Glu Ile Thr Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ile Lys Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asn Leu Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asp Ala Gly Asn Lys Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Ala Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Met 
    690                 695                 700                 


Tyr Ile Gly Asn Asp Glu Gln Ile Asn Thr Ser Leu Ala Gly Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Lys Ile Leu Lys Tyr Thr Glu Ser Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Ala Phe Ser Asp Gln Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Val Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Lys Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Thr Arg Pro Arg Lys Asp Glu Lys Phe Asn Asp Glu Asp Tyr Lys 
        915                 920                 925             


Lys Tyr Glu Lys Ala Ile Arg Asn Ile Gln Gln Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Ser Leu Leu Leu 
945                 950                 955                 960 


Arg Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Cys Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Asn Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Ser Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asp  Met Glu Lys Ile Ser  Ile Tyr Ser Asp Lys  Lys Leu Lys 
    1025                 1030                 1035             


Glu Leu  Lys Lys Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  Asn Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Met Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Val Ile Met Lys Ser  Ile Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Val Thr Phe Lys  Ile Glu Lys Asp Lys  Lys Ile Arg 
    1100                 1105                 1110             


Ile Glu  Ser Leu Lys Ser Glu  Glu Val Val His Leu  Lys Lys Leu 
    1115                 1120                 1125             


Lys Leu  Lys Asp Asn Asp Lys  Lys Lys Glu Pro Ile  Lys Thr Tyr 
    1130                 1135                 1140             


Arg Asn  Ser Lys Glu Leu Cys  Lys Leu Val Lys Val  Met Phe Glu 
    1145                 1150                 1155             


Tyr Lys  Met Lys Glu Lys Lys  Ser Glu Asn 
    1160                 1165             


<210>  331
<211>  1330
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  331

Met Lys Arg Glu Lys Asn Ile Thr Ile Met Lys Ile Ser Lys Val Asn 
1               5                   10                  15      


His Arg Arg Thr Ala Val Ala Leu Asn Gly Asp Lys Ser Glu Leu Gly 
            20                  25                  30          


Gly Ile Leu Tyr Glu Ala Pro Val Gln Lys Asp Lys Asn Gly Asn Tyr 
        35                  40                  45              


Asn Asp Val Ile Ala Glu Thr Gly Lys Val Val Asn Glu Ala Leu Asp 
    50                  55                  60                  


Lys Lys Ser Arg Leu Tyr Thr Pro Phe Asn Asn Gln Lys Val Ile Ile 
65                  70                  75                  80  


Asp Lys Asn Leu Gln Arg Tyr Ala Asn Asn Leu Lys Arg Cys Tyr Ile 
                85                  90                  95      


Asn Phe Val Lys Gln Tyr Val Asn Asn Lys Ser Phe Asn Tyr Lys Ala 
            100                 105                 110         


Met Gln Phe Ile Pro Asp Ile Gln Asn Pro Lys Thr Asn Asp Ala Val 
        115                 120                 125             


Asn Tyr Arg Thr Asp Arg Asp Asn Val Tyr Asn Lys Asn Lys Tyr Tyr 
    130                 135                 140                 


Asp Lys Gln Thr Lys Ser Lys Ser Lys Lys Phe Ile Tyr Glu Lys Ile 
145                 150                 155                 160 


Val Ile Pro Gln Asn Glu Lys Asn Ile Val Ile Ser Ala Leu Val Asn 
                165                 170                 175     


Cys Ser Leu Arg Lys Ser Leu Arg Lys Asp Val Ser Tyr Lys Thr Lys 
            180                 185                 190         


Ser Gly Glu Ile Lys Thr Tyr Asn Leu Pro Glu Leu Val Lys Lys Ser 
        195                 200                 205             


Met Arg Phe Tyr Cys Leu Glu Gly Gln Arg Glu Pro Asp Glu Lys Glu 
    210                 215                 220                 


Lys Tyr Glu Met Tyr Ile Leu Phe Ser Tyr Met Lys Glu Asp Lys Arg 
225                 230                 235                 240 


Thr Lys Asn Thr Asp Leu Leu Val Lys Ser Ile Ser Asn Gln Asn Thr 
                245                 250                 255     


Lys Val Lys Val Glu Asp Ile Asp Gly Asn Lys Leu Leu Lys Leu Ser 
            260                 265                 270         


Ile Ala Asp Thr Lys Lys Lys Pro Leu Trp Glu Tyr Leu Ile Lys Tyr 
        275                 280                 285             


Ala Asp Ser Ser Arg Gln Arg Glu Leu Met Tyr Asp Ile Arg Lys Lys 
    290                 295                 300                 


Ile Ile Leu Tyr Val Ala Gly Ile Glu Glu Tyr Glu Asn Ile Lys Glu 
305                 310                 315                 320 


Asp Ser Gly Leu Ser Lys Val Ser Trp Ser Lys Tyr Asn Ile Ser Asp 
                325                 330                 335     


Asn Lys Met Phe Phe Asp Ile Asn Ser Cys Thr Asp Lys Arg Lys Gln 
            340                 345                 350         


Asn Leu Glu Ile Lys Ile Arg Glu Ala Asn Ile Glu His Tyr Arg Asn 
        355                 360                 365             


Ala Ser Ser Lys Leu Cys Asp Asp Glu Ser Ile Phe Trp Phe Gln His 
    370                 375                 380                 


Phe Glu Gly Val Ile Glu Thr Leu Phe Ser Lys Lys Ser Lys Ile Ser 
385                 390                 395                 400 


Glu Glu Arg Leu Gly Cys Ala Tyr Ile Cys Asp Tyr Leu Trp Lys Asp 
                405                 410                 415     


Phe Leu Ser Tyr Leu Ala Ala Lys Tyr Ile Asp Leu Gly Lys Gly Val 
            420                 425                 430         


Tyr His Phe Thr Met Lys Asp Lys Leu Asp Met Leu Asn Lys Asn Glu 
        435                 440                 445             


Ala Val Thr Asp Leu Arg Phe Gly Ile Val Ser Glu Lys Tyr Glu Lys 
    450                 455                 460                 


Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Glu Leu 
465                 470                 475                 480 


Asp Arg Asn Ile Ala Ala Tyr Val Thr Phe Ala Ala Asp Ile Phe Ala 
                485                 490                 495     


Lys Ser Val Ile Lys Ser Asp Tyr Arg Thr Lys Lys Asp Asn Asn Ser 
            500                 505                 510         


Asp Val Leu Gln Tyr Ser Asp Lys Glu Phe Arg Asn Ser Glu Val Ile 
        515                 520                 525             


Arg Asp Asn Ala Glu Lys Asn Ile Leu Gln Tyr Trp Gly Gly Tyr Ser 
    530                 535                 540                 


Arg Trp Gly Thr Glu Asn Ser Lys Leu Pro Glu Asn Asn Lys Val Ser 
545                 550                 555                 560 


Asp Phe Gly Lys Leu Asp Val Ser Asp Leu Cys Ile Asp Ile Lys Lys 
                565                 570                 575     


His Leu Ala Gly Ile Arg Asn Ser Ser Val His Tyr Thr Thr Lys Ile 
            580                 585                 590         


Lys Asn Glu Ser Ala Ala Asp Gly Ser Asn Val Lys Ile Leu Phe Glu 
        595                 600                 605             


Lys Asp Leu Ala Asp Ile Asn Ile Ile Tyr Ala Asp Lys Tyr Tyr Ser 
    610                 615                 620                 


Asn Asn Val Trp Met Phe Tyr Ser Leu Glu Asp Ile Asn Lys Leu Ile 
625                 630                 635                 640 


Ala Phe Leu Tyr Lys Glu Lys Arg Val Ile Arg Gln Val Gln Ile Pro 
                645                 650                 655     


Ser Phe Ser Arg Ile Leu Lys Arg Lys Ala Met Gln Asp Val Ile Asn 
            660                 665                 670         


Glu Ile Phe Lys Asp Asp Phe Asp Glu Asn Ile Val Asn Pro Glu Leu 
        675                 680                 685             


Lys Glu Lys Tyr Arg Asn Ser Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
    690                 695                 700                 


Tyr Asn Ala Phe Ile Ile Gln Pro Glu Leu Lys Glu Lys Phe Lys Asp 
705                 710                 715                 720 


Lys Ile Lys Thr Met Lys Ser Glu Leu Tyr Asn Lys Leu Lys Thr Ile 
                725                 730                 735     


Asp Lys Lys Glu Tyr Lys Ala Leu Tyr Cys Met Leu Ser Asn Glu Glu 
            740                 745                 750         


Ser Ala Leu Lys Asn Phe Ala Asp Arg Ile Tyr Ser Val Asp Gly Asp 
        755                 760                 765             


Asn Val Ser Phe Ala Asp Ile Cys Lys Ile Leu Met Thr Asp Tyr Asn 
    770                 775                 780                 


Met Gln Asn Gln Glu Lys Lys Asn Ile Glu Ser Met Glu Gln Lys Lys 
785                 790                 795                 800 


Lys Asn Lys Gly Lys Asp Glu Asn Tyr Lys His Phe Pro Leu Leu Leu 
                805                 810                 815     


His Lys Val Leu Lys Lys Leu Phe Ile Glu Tyr Leu Lys Gln Thr His 
            820                 825                 830         


Glu Leu Glu Phe Leu Arg Asn Asn Ile Cys Ile Lys Ser Asp Val Thr 
        835                 840                 845             


Met Glu Ser Phe Glu Ser Gln Ile Lys Gly Val Glu Ile Tyr Lys Asp 
    850                 855                 860                 


Leu Lys Glu Lys Ile Asp Lys Asn Asn Ser Leu Leu Asp Trp Tyr Val 
865                 870                 875                 880 


Ile Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asn 
                885                 890                 895     


Ile Lys Asn Tyr Ile Gln Phe Ala Thr Asn Ile Asp Lys Arg Ala Glu 
            900                 905                 910         


Ser Val Lys Asn Leu Thr Glu Ser Gly Met Val Lys Arg Ile Gln Tyr 
        915                 920                 925             


Tyr Asp Asp Ile Val Arg Thr Leu Glu Phe Ser Ala Gln Tyr Ile Gly 
    930                 935                 940                 


Lys Ile Ser Asn Asn Ile Asn Asp Tyr Phe Asn Ser Glu Asp Glu Tyr 
945                 950                 955                 960 


Val Ser Phe Leu Ser Lys Tyr Val Gly Phe Ile Asn Asp Lys Ser Glu 
                965                 970                 975     


Asp Val Leu Thr Glu Leu Lys Asp Phe Cys Arg Glu Lys Ile Asn Asn 
            980                 985                 990         


Gly Ser Gln Ile Ile Gly Ile Tyr  Tyr Gly Gly Asp Asn  Val Ile Ile 
        995                 1000                 1005             


Asn Arg  Asn Val Ile Tyr Ala  Gln Met Tyr Ser Asn  Ala Glu Val 
    1010                 1015                 1020             


Phe Ser  Asn Ile Tyr Lys Lys  Val Thr Lys Asn Asp  Ile Ile Asn 
    1025                 1030                 1035             


Tyr Tyr  Glu Lys Gln Asn Asp  Leu Lys Asp Val Phe  Lys Ser Gly 
    1040                 1045                 1050             


Val Cys  Gln Asn Glu Gly Glu  Gln Arg Ser Leu Cys  Glu Phe Gln 
    1055                 1060                 1065             


Gln Leu  Lys Asn Arg Ile Glu  Leu Thr Glu Leu Ser  Thr Tyr Ala 
    1070                 1075                 1080             


Asp Met  Val Asn Asp Phe Met  Ala Gln Phe Val Glu  Trp Ala Tyr 
    1085                 1090                 1095             


Leu Arg  Glu Arg Asp Leu Met  Tyr Phe Gln Leu Gly  Ile His Tyr 
    1100                 1105                 1110             


Ile Arg  Leu Phe Tyr Ser Asp  Asn Val Leu Asp Glu  Lys Tyr His 
    1115                 1120                 1125             


Lys Leu  Ser Asp Asn Val Ile  Asp Ile Glu Glu Gly  Ala Leu Leu 
    1130                 1135                 1140             


Tyr Gln  Ile Val Ala Met Tyr  Asp Tyr Glu Leu Arg  Ile Phe Glu 
    1145                 1150                 1155             


Thr Asp  Asn Ser Gly Asn Ala  Lys Arg Ile Gly Gln  Gly Gly Pro 
    1160                 1165                 1170             


Gly Lys  Ser Ile Pro Val Phe  Leu Lys Lys Tyr Cys  Asn Gly Thr 
    1175                 1180                 1185             


Asp Val  Tyr Glu Cys Gly Leu  Glu Leu Phe Glu Asp  Ile Asn Gln 
    1190                 1195                 1200             


His Glu  Asn Ile Ile Gly Phe  Arg Asn Asp Ile Ala  His Met Arg 
    1205                 1210                 1215             


Tyr Met  Ser Asn Gln Ala Met  Asn Ile Met Ser Ile  Val Ser Asn 
    1220                 1225                 1230             


Ile Tyr  Lys Ser Phe Phe Val  Tyr Asp Thr Lys Leu  Lys Lys Ser 
    1235                 1240                 1245             


Ile Ser  Leu Val Phe Lys Asn  Ile Leu Met Arg Tyr  Gly Val Ile 
    1250                 1255                 1260             


Ala Asp  Leu Val Phe Ser Tyr  Asn Asn Lys Asn Gln  Ser Ile Lys 
    1265                 1270                 1275             


Asp Asp  Met Asp Ile Asn Ile  Ile Asn Ile Lys Asn  Leu Lys Ser 
    1280                 1285                 1290             


Asp Lys  Tyr Val Tyr Lys Ile  Val Asn Glu Asp Ile  Val Lys Gln 
    1295                 1300                 1305             


Val Glu  Ile Glu Ile Arg Asn  Gln Val Phe Leu Glu  Gln Leu His 
    1310                 1315                 1320             


Asn Leu  Leu Tyr Phe Ser Arg  
    1325                 1330 


<210>  332
<211>  1330
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  332

Met Lys Arg Glu Lys Asn Ile Thr Ile Met Lys Ile Ser Lys Val Asn 
1               5                   10                  15      


His Arg Arg Met Ala Val Ala Leu Asn Gly Asp Lys Ser Glu Leu Gly 
            20                  25                  30          


Gly Ile Leu Tyr Glu Ala Pro Val Gln Lys Asp Lys Asn Gly Asn Tyr 
        35                  40                  45              


Asn Asp Val Ile Ala Glu Thr Gly Lys Val Val Asn Glu Ala Leu Asp 
    50                  55                  60                  


Lys Lys Ser Arg Leu Tyr Thr Pro Phe Asn Asn Gln Lys Val Ile Ile 
65                  70                  75                  80  


Asp Lys Asn Leu Gln Arg Tyr Ala Asn Asn Leu Lys Arg Cys Tyr Ile 
                85                  90                  95      


Asn Phe Val Lys Gln Tyr Val Asn Asn Lys Ser Phe Asn Tyr Lys Ala 
            100                 105                 110         


Met Gln Phe Ile Pro Asp Ile Gln Asn Pro Lys Thr Asn Asp Ala Val 
        115                 120                 125             


Asn Tyr Arg Thr Asp Arg Asp Asn Val Tyr Asn Lys Asn Lys Tyr Tyr 
    130                 135                 140                 


Asp Lys Gln Thr Lys Ser Lys Ser Lys Lys Phe Ile Tyr Glu Lys Ile 
145                 150                 155                 160 


Val Ile Pro Gln Asn Glu Gln Asn Ile Val Ile Ser Ala Leu Val Asn 
                165                 170                 175     


Cys Ser Leu Arg Lys Ser Leu Arg Lys Asp Val Ser Tyr Lys Thr Lys 
            180                 185                 190         


Ser Gly Glu Ile Lys Thr Tyr Asn Leu Pro Glu Leu Val Lys Lys Ser 
        195                 200                 205             


Met Arg Phe Tyr Cys Leu Glu Gly Gln Arg Glu Pro Asp Glu Lys Glu 
    210                 215                 220                 


Lys Tyr Glu Met Tyr Ile Leu Phe Ser Tyr Met Lys Glu Asp Lys Arg 
225                 230                 235                 240 


Thr Lys Asn Thr Asp Leu Leu Val Lys Ser Ile Ser Asn Gln Asn Thr 
                245                 250                 255     


Lys Val Lys Val Glu Asp Ile Asp Gly Asn Lys Leu Leu Lys Leu Ser 
            260                 265                 270         


Ile Ala Asp Thr Lys Lys Glu Pro Leu Trp Glu Tyr Leu Ile Lys Tyr 
        275                 280                 285             


Ala Asp Ser Ser Arg Gln Arg Glu Leu Met Tyr Asp Ile Arg Lys Lys 
    290                 295                 300                 


Ile Val Leu Tyr Val Val Gly Ile Glu Glu Tyr Glu Asn Ile Lys Glu 
305                 310                 315                 320 


Asp Ser Gly Leu Ser Lys Val Ser Trp Ser Lys Tyr Asn Ile Ser Asp 
                325                 330                 335     


Asn Lys Met Phe Phe Asp Ile Asn Ser Cys Thr Asp Lys Arg Lys Gln 
            340                 345                 350         


Asn Leu Glu Ile Lys Ile Arg Glu Ala Asn Ile Glu His Tyr Arg Asn 
        355                 360                 365             


Ala Ser Ser Lys Leu Cys Asp Asp Glu Ser Ile Phe Trp Phe Gln His 
    370                 375                 380                 


Phe Glu Gly Val Ile Glu Thr Leu Phe Ser Lys Lys Ser Lys Ile Ser 
385                 390                 395                 400 


Glu Glu Arg Leu Gly Cys Ala Tyr Ile Cys Asp Tyr Leu Trp Lys Asp 
                405                 410                 415     


Phe Leu Ser Tyr Leu Ala Ala Lys Tyr Ile Asp Leu Gly Lys Gly Val 
            420                 425                 430         


Tyr His Phe Thr Met Lys Asp Lys Leu Asp Met Leu Asn Lys Asn Glu 
        435                 440                 445             


Ala Val Thr Asp Leu Arg Phe Gly Ile Val Ser Glu Lys Tyr Glu Lys 
    450                 455                 460                 


Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Glu Leu 
465                 470                 475                 480 


Asp Arg Asn Ile Ala Ala Tyr Val Thr Phe Ala Ala Asp Ile Phe Ala 
                485                 490                 495     


Lys Ser Val Ile Lys Ser Asp Tyr Arg Thr Lys Lys Asp Asn Asn Ser 
            500                 505                 510         


Asp Val Leu Gln Tyr Ser Asp Lys Glu Phe Arg Asn Ser Glu Val Ile 
        515                 520                 525             


Arg Asp Asn Ala Glu Lys Asn Ile Leu Gln Tyr Trp Gly Gly Tyr Ser 
    530                 535                 540                 


Arg Trp Gly Thr Glu Asn Ser Lys Leu Pro Glu Asn Asn Lys Val Ser 
545                 550                 555                 560 


Asp Phe Gly Lys Leu Asp Val Ser Asp Leu Cys Ile Asp Ile Lys Lys 
                565                 570                 575     


His Leu Ala Gly Ile Arg Asn Ser Ser Val His Tyr Thr Thr Lys Ile 
            580                 585                 590         


Lys Asn Glu Ser Ala Ala Asp Gly Ser Asn Val Lys Ile Leu Phe Glu 
        595                 600                 605             


Lys Asp Leu Ala Asp Ile Asn Ile Ile Tyr Ala Asp Lys Tyr Tyr Ser 
    610                 615                 620                 


Asn Asn Val Trp Met Phe Tyr Ser Leu Glu Asp Ile Asn Lys Leu Ile 
625                 630                 635                 640 


Ala Phe Leu Tyr Lys Glu Lys Arg Val Ile Arg Gln Val Gln Ile Pro 
                645                 650                 655     


Ser Phe Ser Arg Ile Leu Lys Arg Lys Ala Met Gln Asp Val Ile Asn 
            660                 665                 670         


Glu Ile Phe Lys Asp Asp Phe Asp Glu Asn Ile Val Asn Pro Glu Leu 
        675                 680                 685             


Lys Glu Lys Tyr Arg Asn Ser Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
    690                 695                 700                 


Tyr Asn Ala Phe Ile Ile Gln Pro Glu Leu Lys Glu Lys Phe Lys Asp 
705                 710                 715                 720 


Lys Ile Lys Thr Met Lys Ser Glu Leu Tyr Asn Lys Leu Lys Thr Ile 
                725                 730                 735     


Asp Lys Lys Glu Tyr Lys Ala Leu Tyr Cys Met Leu Ser Asn Glu Glu 
            740                 745                 750         


Ser Ala Leu Lys Asn Phe Ala Asp Arg Ile Tyr Ser Val Asp Gly Asp 
        755                 760                 765             


Asn Val Ser Phe Ala Asp Ile Cys Lys Ile Leu Met Thr Asp Tyr Asn 
    770                 775                 780                 


Met Gln Asn Gln Glu Lys Lys Asn Ile Glu Ser Met Glu Gln Lys Lys 
785                 790                 795                 800 


Lys Asn Lys Gly Lys Asp Glu Asn Tyr Lys His Phe Pro Leu Leu Leu 
                805                 810                 815     


His Lys Val Leu Lys Glu Leu Phe Ile Glu Tyr Leu Lys Gln Thr His 
            820                 825                 830         


Glu Leu Glu Phe Leu Arg Asn Asn Ile Cys Ile Lys Ser Asp Val Thr 
        835                 840                 845             


Met Glu Ser Phe Glu Ser Gln Ile Lys Gly Val Glu Ile Tyr Lys Asp 
    850                 855                 860                 


Leu Lys Glu Lys Ile Asp Lys Asn Asn Ser Leu Leu Asp Trp Tyr Val 
865                 870                 875                 880 


Ile Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asn 
                885                 890                 895     


Ile Lys Asn Tyr Ile Gln Phe Ala Thr Asn Ile Asp Lys Arg Ala Glu 
            900                 905                 910         


Ser Val Lys Asn Leu Thr Glu Ser Gly Met Val Lys Arg Ile Gln Tyr 
        915                 920                 925             


Tyr Asp Asp Ile Val Arg Thr Leu Glu Phe Ser Ala Gln Tyr Ile Gly 
    930                 935                 940                 


Lys Ile Ser Asn Asn Ile Asn Asp Tyr Phe Asn Ser Glu Asp Glu Tyr 
945                 950                 955                 960 


Val Ser Phe Leu Ser Lys Tyr Val Gly Phe Ile Asn Asp Lys Ser Glu 
                965                 970                 975     


Asp Val Leu Thr Glu Leu Lys Asp Phe Cys Arg Glu Lys Ile Asn Asn 
            980                 985                 990         


Gly Ser Gln Ile Ile Gly Ile Tyr  Tyr Gly Gly Asp Asn  Val Ile Ile 
        995                 1000                 1005             


Asn Arg  Asn Val Ile Tyr Ala  Gln Met Tyr Ser Asn  Ala Glu Val 
    1010                 1015                 1020             


Phe Ser  Asn Ile Tyr Lys Lys  Val Thr Lys Asn Asp  Ile Ile Asn 
    1025                 1030                 1035             


Tyr Tyr  Glu Lys Gln Asn Asp  Leu Lys Asp Val Phe  Lys Arg Gly 
    1040                 1045                 1050             


Val Cys  Gln Asn Glu Gly Glu  Gln Arg Ser Leu Cys  Glu Phe Gln 
    1055                 1060                 1065             


Gln Leu  Lys Asn Arg Ile Glu  Leu Thr Glu Leu Ser  Thr Tyr Ala 
    1070                 1075                 1080             


Asp Met  Val Asn Asp Phe Met  Ala Gln Phe Val Glu  Trp Ala Tyr 
    1085                 1090                 1095             


Leu Arg  Glu Arg Asp Leu Met  Tyr Phe Gln Leu Gly  Ile His Tyr 
    1100                 1105                 1110             


Ile Arg  Leu Phe Tyr Ser Asp  Asn Val Leu Asp Glu  Lys Tyr His 
    1115                 1120                 1125             


Lys Leu  Ser Asp Asn Val Ile  Asp Ile Glu Glu Gly  Ala Leu Leu 
    1130                 1135                 1140             


Tyr Gln  Ile Val Ala Met Tyr  Asp Tyr Glu Leu Arg  Ile Phe Glu 
    1145                 1150                 1155             


Thr Asp  Asn Ser Gly Asn Ala  Lys Arg Ile Gly Gln  Gly Gly Pro 
    1160                 1165                 1170             


Gly Lys  Ser Ile Pro Val Phe  Leu Lys Lys Tyr Cys  Asn Gly Thr 
    1175                 1180                 1185             


Asp Val  Tyr Glu Cys Gly Leu  Glu Leu Phe Glu Asp  Ile Asn Gln 
    1190                 1195                 1200             


His Glu  His Ile Ile Arg Phe  Arg Asn Asp Ile Ala  His Met Arg 
    1205                 1210                 1215             


Tyr Met  Ser Asn Gln Ala Met  Asn Ile Met Ser Ile  Val Ser Asn 
    1220                 1225                 1230             


Ile Tyr  Lys Ser Phe Phe Val  Tyr Asp Thr Lys Leu  Lys Lys Ser 
    1235                 1240                 1245             


Ile Ser  Leu Val Phe Lys Asn  Ile Leu Met Arg Tyr  Gly Val Ile 
    1250                 1255                 1260             


Ala Asp  Leu Val Phe Ser Tyr  Asn Asn Lys Asn Gln  Ser Ile Lys 
    1265                 1270                 1275             


Asp Asp  Met Asp Ile Asn Ile  Ile Asn Ile Lys Asn  Leu Lys Ser 
    1280                 1285                 1290             


Asp Lys  Tyr Val Tyr Lys Ile  Val Asn Glu Asp Ile  Val Lys Gln 
    1295                 1300                 1305             


Val Glu  Ile Glu Ile Arg Asn  Gln Val Phe Leu Glu  Gln Leu His 
    1310                 1315                 1320             


Asn Leu  Leu Tyr Phe Ser Arg  
    1325                 1330 


<210>  333
<211>  1330
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  333

Met Lys Arg Glu Lys Asn Ile Thr Ile Met Lys Ile Ser Lys Val Asn 
1               5                   10                  15      


His Arg Arg Met Ala Val Ala Leu Asn Gly Asp Lys Ser Glu Leu Gly 
            20                  25                  30          


Gly Ile Leu Tyr Glu Ala Pro Val Gln Lys Asp Lys Asn Gly Asn Tyr 
        35                  40                  45              


Asn Asp Val Ile Ala Glu Thr Gly Lys Val Val Asn Glu Ala Leu Asp 
    50                  55                  60                  


Lys Lys Ser Arg Leu Tyr Thr Pro Phe Asn Asn Gln Lys Val Ile Ile 
65                  70                  75                  80  


Asp Lys Asn Leu Gln Arg Tyr Ala Asn Asn Leu Lys Arg Cys Tyr Ile 
                85                  90                  95      


Asn Phe Val Lys Gln Tyr Val Asn Asn Lys Ser Phe Asn Tyr Lys Ala 
            100                 105                 110         


Met Gln Phe Ile Pro Asp Ile Gln Asn Pro Lys Thr Asn Asp Ala Val 
        115                 120                 125             


Asn Tyr Arg Thr Asp Arg Asp Asn Val Tyr Asn Lys Asn Lys Tyr Tyr 
    130                 135                 140                 


Asp Lys Gln Thr Lys Ser Lys Ser Lys Lys Phe Ile Tyr Glu Lys Ile 
145                 150                 155                 160 


Val Ile Pro Gln Asn Glu Gln Asn Ile Val Ile Ser Ala Leu Val Asn 
                165                 170                 175     


Cys Ser Leu Arg Lys Ser Leu Arg Lys Asp Val Ser Tyr Lys Thr Lys 
            180                 185                 190         


Ser Gly Glu Ile Lys Thr Tyr Asn Leu Pro Glu Leu Val Lys Lys Ser 
        195                 200                 205             


Met Arg Phe Tyr Cys Leu Glu Gly Gln Arg Glu Pro Asp Glu Lys Glu 
    210                 215                 220                 


Lys Tyr Glu Met Tyr Ile Leu Phe Ser Tyr Met Lys Glu Asp Lys Arg 
225                 230                 235                 240 


Thr Lys Asn Thr Asp Leu Leu Val Lys Ser Ile Ser Asn Gln Asn Thr 
                245                 250                 255     


Lys Val Lys Val Glu Asp Ile Asp Gly Asn Lys Leu Leu Lys Leu Ser 
            260                 265                 270         


Ile Ala Asp Thr Lys Lys Glu Pro Leu Trp Glu Tyr Leu Ile Lys Tyr 
        275                 280                 285             


Ala Asp Ser Ser Arg Gln Arg Glu Leu Met Tyr Asp Ile Arg Lys Lys 
    290                 295                 300                 


Ile Val Leu Tyr Val Val Gly Ile Glu Glu Tyr Glu Asn Ile Lys Glu 
305                 310                 315                 320 


Asp Ser Gly Leu Ser Lys Val Ser Trp Ser Lys Tyr Asn Ile Ser Asp 
                325                 330                 335     


Asn Lys Met Phe Phe Asp Ile Asn Ser Cys Thr Asp Lys Arg Lys Gln 
            340                 345                 350         


Asn Leu Glu Ile Lys Ile Arg Glu Ala Asn Ile Glu His Tyr Arg Asn 
        355                 360                 365             


Ala Ser Ser Lys Leu Cys Asp Asp Glu Ser Ile Phe Trp Phe Gln His 
    370                 375                 380                 


Phe Glu Gly Val Ile Glu Thr Leu Phe Ser Lys Lys Ser Lys Ile Ser 
385                 390                 395                 400 


Glu Glu Arg Leu Gly Cys Ala Tyr Ile Cys Asp Tyr Leu Trp Lys Asp 
                405                 410                 415     


Phe Leu Ser Tyr Leu Ala Ala Lys Tyr Ile Asp Leu Gly Lys Gly Val 
            420                 425                 430         


Tyr His Phe Thr Met Lys Asp Lys Leu Asp Met Leu Asn Lys Asn Glu 
        435                 440                 445             


Ala Val Thr Asp Leu Arg Phe Gly Ile Val Ser Glu Lys Tyr Glu Lys 
    450                 455                 460                 


Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Glu Leu 
465                 470                 475                 480 


Asp Arg Asn Ile Ala Ala Tyr Val Thr Phe Ala Ala Asp Ile Phe Ala 
                485                 490                 495     


Lys Ser Val Ile Lys Ser Asp Tyr Arg Thr Lys Lys Asp Asn Asn Ser 
            500                 505                 510         


Asp Val Leu Gln Tyr Ser Asp Lys Glu Phe Arg Asn Ser Glu Val Ile 
        515                 520                 525             


Arg Asp Asn Ala Glu Lys Asn Ile Leu Gln Tyr Trp Gly Gly Tyr Ser 
    530                 535                 540                 


Arg Trp Gly Thr Glu Asn Ser Lys Leu Pro Glu Asn Asn Lys Val Ser 
545                 550                 555                 560 


Asp Phe Gly Lys Leu Asp Val Ser Asp Leu Cys Ile Asp Ile Lys Lys 
                565                 570                 575     


His Leu Ala Gly Ile Arg Asn Ser Ser Val His Tyr Thr Thr Lys Ile 
            580                 585                 590         


Lys Asn Glu Ser Ala Ala Asp Gly Ser Asn Val Lys Ile Leu Phe Glu 
        595                 600                 605             


Lys Asp Leu Ala Asp Ile Asn Ile Ile Tyr Ala Asp Lys Tyr Tyr Ser 
    610                 615                 620                 


Asn Asn Val Trp Met Phe Tyr Ser Leu Glu Asp Ile Asn Lys Leu Ile 
625                 630                 635                 640 


Ala Phe Leu Tyr Lys Glu Lys Arg Val Ile Arg Gln Val Gln Ile Pro 
                645                 650                 655     


Ser Phe Ser Arg Ile Leu Lys Arg Lys Ala Met Gln Asp Val Ile Asn 
            660                 665                 670         


Glu Ile Phe Lys Asp Asp Phe Asp Glu Asn Ile Val Asn Pro Glu Leu 
        675                 680                 685             


Lys Glu Lys Tyr Arg Asn Ser Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
    690                 695                 700                 


Tyr Asn Ala Phe Ile Ile Gln Pro Glu Leu Lys Glu Lys Phe Lys Asp 
705                 710                 715                 720 


Lys Ile Lys Thr Met Lys Ser Glu Leu Tyr Asn Lys Leu Lys Thr Ile 
                725                 730                 735     


Asp Lys Lys Glu Tyr Lys Ala Leu Tyr Cys Met Leu Ser Asn Glu Glu 
            740                 745                 750         


Ser Ala Leu Lys Asn Phe Ala Asp Arg Ile Tyr Ser Val Asp Gly Asp 
        755                 760                 765             


Asn Val Ser Phe Ala Asp Ile Cys Lys Ile Leu Met Thr Asp Tyr Asn 
    770                 775                 780                 


Met Gln Asn Gln Glu Lys Lys Asn Ile Glu Ser Met Glu Gln Lys Lys 
785                 790                 795                 800 


Lys Asn Lys Gly Lys Asp Glu Asn Tyr Lys His Phe Pro Leu Leu Leu 
                805                 810                 815     


His Lys Val Leu Lys Glu Leu Phe Ile Glu Tyr Leu Lys Gln Thr His 
            820                 825                 830         


Glu Leu Glu Phe Leu Arg Asn Asn Ile Cys Ile Lys Ser Asp Val Thr 
        835                 840                 845             


Met Glu Ser Phe Glu Ser Gln Ile Lys Gly Val Glu Ile Tyr Lys Asp 
    850                 855                 860                 


Leu Lys Glu Lys Ile Asp Lys Asn Asn Ser Leu Leu Asp Trp Tyr Val 
865                 870                 875                 880 


Ile Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asn 
                885                 890                 895     


Ile Lys Asn Tyr Ile Gln Phe Ala Thr Asn Ile Asp Lys Arg Ala Glu 
            900                 905                 910         


Ser Val Lys Asn Leu Thr Glu Ser Gly Met Val Lys Arg Ile Gln Tyr 
        915                 920                 925             


Tyr Asp Asp Ile Val Arg Thr Leu Glu Phe Ser Ala Gln Tyr Ile Gly 
    930                 935                 940                 


Lys Ile Ser Asn Asn Ile Asn Asp Tyr Phe Asn Ser Glu Asp Glu Tyr 
945                 950                 955                 960 


Val Ser Phe Leu Ser Lys Tyr Val Gly Phe Ile Asn Asp Lys Ser Glu 
                965                 970                 975     


Asp Val Leu Thr Glu Leu Lys Asp Phe Cys Arg Glu Lys Ile Asn Asn 
            980                 985                 990         


Gly Ser Gln Ile Ile Gly Ile Tyr  Tyr Gly Gly Asp Asn  Val Ile Ile 
        995                 1000                 1005             


Asn Arg  Asn Val Ile Tyr Ala  Gln Met Tyr Ser Asn  Ala Glu Val 
    1010                 1015                 1020             


Phe Ser  Asn Ile Tyr Lys Lys  Val Thr Lys Asn Asp  Ile Ile Asn 
    1025                 1030                 1035             


Tyr Tyr  Glu Lys Gln Asn Asp  Leu Lys Asp Val Phe  Lys Arg Gly 
    1040                 1045                 1050             


Val Cys  Gln Asn Glu Gly Glu  Gln Arg Ser Leu Cys  Glu Phe Gln 
    1055                 1060                 1065             


Gln Leu  Lys Asn Arg Ile Glu  Leu Thr Glu Leu Ser  Thr Tyr Ala 
    1070                 1075                 1080             


Asp Met  Val Asn Asp Phe Met  Ala Gln Phe Val Glu  Trp Ala Tyr 
    1085                 1090                 1095             


Leu Arg  Glu Arg Asp Leu Met  Tyr Phe Gln Leu Gly  Ile His Tyr 
    1100                 1105                 1110             


Ile Arg  Leu Phe Tyr Ser Asp  Asn Val Leu Asp Glu  Lys Tyr His 
    1115                 1120                 1125             


Lys Leu  Ser Asp Asn Val Ile  Asp Ile Glu Glu Gly  Ala Leu Leu 
    1130                 1135                 1140             


Tyr Gln  Ile Val Ala Met Tyr  Asp Tyr Glu Leu Arg  Ile Phe Glu 
    1145                 1150                 1155             


Thr Asp  Asn Ser Gly Asn Ala  Lys Arg Ile Gly Gln  Gly Gly Pro 
    1160                 1165                 1170             


Gly Lys  Ser Ile Pro Val Phe  Leu Lys Lys Tyr Cys  Asn Gly Thr 
    1175                 1180                 1185             


Asp Val  Tyr Glu Cys Gly Leu  Glu Leu Phe Glu Asp  Ile Asn Gln 
    1190                 1195                 1200             


His Glu  His Ile Ile Arg Phe  Arg Asn Asp Ile Ala  His Met Arg 
    1205                 1210                 1215             


Tyr Met  Ser Asn Gln Ala Met  Asn Ile Met Ser Ile  Val Ser Asn 
    1220                 1225                 1230             


Ile Tyr  Lys Ser Phe Phe Val  Tyr Asp Thr Lys Leu  Lys Lys Ser 
    1235                 1240                 1245             


Ile Ser  Leu Val Phe Lys Asn  Ile Leu Met Arg Tyr  Gly Val Ile 
    1250                 1255                 1260             


Ala Asp  Leu Val Phe Ser Tyr  Asn Asn Lys Asn Gln  Ser Ile Lys 
    1265                 1270                 1275             


Asp Asp  Met Asp Ile Asn Ile  Ile Asn Ile Lys Asn  Leu Lys Ser 
    1280                 1285                 1290             


Asp Lys  Tyr Val Tyr Lys Ile  Val Asn Glu Asp Ile  Val Lys Gln 
    1295                 1300                 1305             


Val Glu  Ile Glu Ile Arg Asn  Gln Val Phe Leu Glu  Gln Leu His 
    1310                 1315                 1320             


Asn Leu  Leu Tyr Phe Ser Arg  
    1325                 1330 


<210>  334
<211>  1223
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  334

Val Lys Leu Ser Lys Arg Lys Ile Asn Ala Asp Gly Lys Ala Val Ala 
1               5                   10                  15      


Phe Tyr Arg Asp Leu Phe His Gly Lys Leu Tyr Leu Val Ser Glu Lys 
            20                  25                  30          


His Asp Tyr Thr Arg Glu Thr Val Asp Lys Met Asp Phe Glu Arg Ser 
        35                  40                  45              


Trp Arg Gly Arg Ile Leu Lys Asp Ala Glu Lys Lys Phe Asn Pro Phe 
    50                  55                  60                  


Tyr Ser Ile Val Asp Gly Leu Val Lys Ser Asp Arg Asn Val Thr Ile 
65                  70                  75                  80  


Asn Ile Asn Leu Ser Asn Gly Asn Lys Ser Ser Asp Val Gly Met Leu 
                85                  90                  95      


Ile Arg Asp Asn Leu Thr Trp Phe Gly Arg Arg Leu Lys Ala Pro Asp 
            100                 105                 110         


Ser Glu Tyr Thr Leu Glu Ala Leu Ile Cys Lys Ile Leu Ala Gly Glu 
        115                 120                 125             


Asn Gln Asp Glu Ile Arg Ala Asn Leu Glu Lys Leu Lys Asn Ile Ile 
    130                 135                 140                 


Gln Glu Ser Ile Glu Arg Gln Lys Asp Gly Leu Cys Lys Ser Ile Gln 
145                 150                 155                 160 


Asn Asn Arg Ile Pro Phe Ser Leu Asn Gly Asp Lys Ile Glu Ala Ser 
                165                 170                 175     


Ser Lys Lys Met Lys Trp Leu Tyr Ser Phe Leu Asp Gly Lys Ile Asp 
            180                 185                 190         


Glu His Met Leu Asp Asp Tyr Trp Val Ile Tyr Lys Tyr Asn Glu Leu 
        195                 200                 205             


Glu Asn Lys Ile Asn Gln Asn Val Asp Gly Ile Lys Asn Lys Asp Ala 
    210                 215                 220                 


Arg Ser Ile Ser Lys Ala Val Ser Lys Ala Val His Glu His His His 
225                 230                 235                 240 


Gln Ile Arg Ile Arg Gly Ile Asn Asn Asp Gln Leu Leu Phe Leu Lys 
                245                 250                 255     


Ala Val Glu Gln His Phe Lys Lys Tyr Tyr Pro Val Lys Ser Lys His 
            260                 265                 270         


Ser Ser Asn Val Tyr Asp Glu Lys Leu Lys Gln Glu Lys Asn Tyr Lys 
        275                 280                 285             


Phe Tyr Tyr Ser Glu Asn Phe Val Lys Gly Glu Val Arg Arg Ser Ile 
    290                 295                 300                 


Val Asn Gln Leu Val Ser Gly Leu Ile Gln Gln Gly Lys Leu Leu His 
305                 310                 315                 320 


Tyr Phe Tyr Asp Glu Thr Gln Gly Trp Gln Lys Asp Tyr Leu Asn Ser 
                325                 330                 335     


Tyr Gly Leu Ser Tyr Ile Gln Val Glu Glu Ala Phe Lys Lys Ser Leu 
            340                 345                 350         


Met Asp Ser Ile Ser Trp Ala Ile Asn Arg Leu Tyr Tyr Phe Val Tyr 
        355                 360                 365             


Asp Pro Asp Asp Ser Glu Asn Glu Ile Asn Asp Asn Ile Val Thr Leu 
    370                 375                 380                 


Tyr Arg Asp Ile Ile Ser Ala Leu Gly Asn Ile Thr Ile Asp Glu Asn 
385                 390                 395                 400 


Gly Asn Leu Tyr Asp Lys Ile Asn Asn Pro Ile Thr Cys Glu Thr Lys 
                405                 410                 415     


Asn Gly Pro Gln Ile Val Lys Leu Met Ser Arg Ile Tyr Tyr His Glu 
            420                 425                 430         


Val Lys Asp Glu Lys Gly Asn Asn Phe Tyr Pro Glu Gln Asp Lys Phe 
        435                 440                 445             


Ser Lys Lys Val Ala Gln Tyr Phe Pro Ile Arg Asp Lys Asp Ser Phe 
    450                 455                 460                 


Asn Thr Ile Ala Arg Leu Phe Tyr Glu Ala Lys Glu Ser Ile Ala His 
465                 470                 475                 480 


Leu Arg His Gln Asn Phe His Tyr Arg Lys Asn Ser Leu Ile Asp Ile 
                485                 490                 495     


Leu Ala Ser Ser Lys Gly Ser Trp Asn Lys Ser Lys Leu Met Leu Val 
            500                 505                 510         


Arg Asp Ile Tyr Tyr Ile His Asn Tyr Phe Arg Glu His Ile Arg Ser 
        515                 520                 525             


Thr Gly Ile Leu Asp Tyr Tyr Pro Val Glu Phe Leu Lys Glu Cys Ile 
    530                 535                 540                 


Glu Ala Cys Gly Leu Asn Phe Asn Leu Tyr Ala Pro Asn Asn Ser Leu 
545                 550                 555                 560 


Trp Pro Ser Phe Ser Lys Val Tyr Lys Lys Gly Ser Asn Leu Tyr Lys 
                565                 570                 575     


Ser Glu Lys Asp His Lys Gly Leu Lys Trp Tyr Ile Glu Val Ala Asn 
            580                 585                 590         


His Asp Ala Gly Ser Leu Ala Tyr Lys Asn Phe Leu Lys Leu Ile Tyr 
        595                 600                 605             


Tyr His Ser Phe Leu Pro Ala Val Thr Gln Glu Gln Ser Leu Ile Thr 
    610                 615                 620                 


Asn Phe Ile Asn Ser Thr Lys Lys Trp Asn Arg Glu Glu Ala Gly Lys 
625                 630                 635                 640 


Ala Ala Gln Arg Arg Asn Asn Asp Lys Ser Lys Asn Ser Asp Ser Ser 
                645                 650                 655     


Val Lys Ala Tyr Arg Tyr Glu Ala Met Pro Asp Tyr Lys Gly Glu Pro 
            660                 665                 670         


Leu Ala Asp Tyr Phe Lys Ala Leu Gln Lys Glu Gln Ile Ala Gln Ala 
        675                 680                 685             


Asn Lys Val Gln Glu Gly Glu Ala Glu Lys Asn Asn Tyr Ile Leu Phe 
    690                 695                 700                 


Ile Gln Asp Val Phe Val Arg Ala Phe Asp Asp Tyr Leu Ser Arg Leu 
705                 710                 715                 720 


Glu Lys Tyr Arg Glu Lys Leu Gln Ser Pro Thr Lys Gln Asp Ile Asn 
                725                 730                 735     


Val Asn Asp Ala Leu Glu Met Leu Val Pro Lys Ala Arg Gly Lys Ser 
            740                 745                 750         


Ser Ile Arg Met Lys Cys Ser Phe Glu Gly Thr His Asn Ile Glu Asp 
        755                 760                 765             


Asn Ile Leu Cys Phe Tyr Pro Phe Leu Arg Leu Leu Asp Ala Lys Glu 
    770                 775                 780                 


Leu Ser Thr Leu Gln His Gln Phe Val Arg Tyr Arg Cys Ser Leu Asn 
785                 790                 795                 800 


Glu Arg Thr Leu Pro Glu Ser Gln Glu Thr Met Lys Glu Glu Leu Ile 
                805                 810                 815     


Lys Phe Leu Ile Glu Leu Glu Glu Leu Ile Glu Leu Val Arg Phe Thr 
            820                 825                 830         


Ile Pro Ala Thr Arg Ser Asp Lys Val Glu Ser Val Tyr Lys Thr Met 
        835                 840                 845             


Phe Glu Val His Phe Ser Asp Phe Leu Asp Lys Asp Val Leu Lys Asn 
    850                 855                 860                 


Gln Glu Cys Ser Arg Leu Tyr Leu Gln Ser Asn Gly Lys Thr Ala Ile 
865                 870                 875                 880 


Pro Arg Lys His Met Met Leu Leu Ala Arg Ser Ala Pro Met Pro Leu 
                885                 890                 895     


Tyr Arg Lys Met Phe Lys Asp Tyr Tyr Arg Ile Thr Glu Ala Glu Cys 
            900                 905                 910         


Leu Glu Tyr Ile Lys Leu Gly Gln Thr Ile Glu Gln Asp Ile Asn Lys 
        915                 920                 925             


Leu Thr Glu Leu His Lys Glu Leu Glu Lys Ala Arg Leu Lys Phe Asn 
    930                 935                 940                 


Leu Glu Asp Asn His Asn Gly Lys Ser Asp Pro Asn Tyr Asp Lys Leu 
945                 950                 955                 960 


Val Gln Lys Val Lys Asp Tyr Ala Glu Lys Leu Gln Cys Val Val Arg 
                965                 970                 975     


Tyr Lys His Leu Arg Arg Lys Leu Thr Phe Glu Ser Leu Tyr Lys Leu 
            980                 985                 990         


Phe Ser Ile His Val Asp Leu His  Gly Val Met Leu Ala  Phe Val Gln 
        995                 1000                 1005             


Asn Trp  Glu Arg Asp Met Phe  Phe Leu Leu Thr Ala  Leu Lys Tyr 
    1010                 1015                 1020             


Met Gly  Tyr Val Lys Gly Lys  Ser Asp Asp Cys Val  Asp Arg Ile 
    1025                 1030                 1035             


Phe Ala  Lys Gly Lys Val Ile  His Asn Leu Leu Asn  Ser Lys Glu 
    1040                 1045                 1050             


Tyr Leu  Arg Asp Asp Asp Lys  Asn Leu Leu Ala Ser  Leu Cys Trp 
    1055                 1060                 1065             


Asn Glu  Ser Ser Lys Ser Asn  Ile Lys Glu Asn Lys  Ile Lys Val 
    1070                 1075                 1080             


Arg Asn  Val Ile Ser His Leu  Asn His Phe Thr Gln  Ser Ser Asn 
    1085                 1090                 1095             


Asn Lys  Gln Pro Ser Ile Glu  Glu Met Ile Asn Asn  Leu Arg Tyr 
    1100                 1105                 1110             


Leu Leu  Tyr Tyr Asp Arg Lys  Arg Gln Asn Ala Val  Thr Lys Ser 
    1115                 1120                 1125             


Ile Lys  Asp Leu Met Leu Lys  Glu His Asn Ile Lys  Ile Ser Trp 
    1130                 1135                 1140             


Lys Asn  Ala Thr Asn Ala Gln  Gly Asn Val Glu Leu  Lys Thr Lys 
    1145                 1150                 1155             


Arg Val  Glu Asp Ala Thr Ile  Glu His Leu Lys His  Ile Cys Lys 
    1160                 1165                 1170             


Gly Lys  Ser Cys Asn Ser Asn  Lys Val Pro Cys Pro  Ile Asn Gln 
    1175                 1180                 1185             


Asn Asp  Lys Ala Asn Ser Cys  Gly Leu Leu Glu Gln  Ser Asn Ser 
    1190                 1195                 1200             


Thr Glu  Leu Leu Arg Cys Leu  Asp Arg Leu Ile Thr  Phe Glu Tyr 
    1205                 1210                 1215             


Thr Ser  Ala Asn Pro 
    1220             


<210>  335
<211>  1217
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  335

Met Lys Ile Thr Lys Arg Lys Trp Glu Asn Ile Pro Pro Val Phe Ile 
1               5                   10                  15      


Tyr Arg Asp Val Glu Ser Gly Lys Leu Phe Thr Glu Cys Asp Arg Gln 
            20                  25                  30          


Gln Asp Tyr Thr Asp Lys Leu Phe Gln Asp Glu Cys Ser Ala Ser Asp 
        35                  40                  45              


Val Phe Lys Ile Ser Leu Gln Asn Arg Leu Phe Arg Met Gln Lys Asp 
    50                  55                  60                  


Gly Lys Thr Arg Val Lys Asn Glu Ile Thr Glu Leu Val Ala Cys Leu 
65                  70                  75                  80  


Cys Lys Asn Thr Asp Leu Arg Asn Ser Ile Asn Lys Val Lys Lys Leu 
                85                  90                  95      


Pro Leu Asn Val Ala Glu Lys Lys Cys Asn Glu Thr Leu Ser Asp Tyr 
            100                 105                 110         


Gly Lys Ser Phe Thr Ala Glu Gly Gly Thr Lys Thr Leu Phe Asn Ala 
        115                 120                 125             


Leu Leu Asp Leu Val Lys Gly Asn Asp Glu Glu Arg Ala Leu Ala Glu 
    130                 135                 140                 


Ala Glu Leu Val Lys Ile Gln Lys Ile Leu Gln Glu Glu Ile Lys His 
145                 150                 155                 160 


Arg Lys Lys Arg Ile Tyr Ser Ser Ile Arg Asn Asn Lys Ile Pro Leu 
                165                 170                 175     


Leu Ile Lys Glu Asp Gly Ser Ile Glu Ala Asn Ser Asp Arg Thr Ala 
            180                 185                 190         


Trp Leu Leu Asp Leu Leu Gln Pro Val Gln Ser Ser Leu Gln His Asp 
        195                 200                 205             


Ser Asp Asp Phe Tyr Pro Val Leu Thr Glu Met Glu Lys Ile Phe Asp 
    210                 215                 220                 


Tyr Asp Lys Leu Ser Asn Asp Ile Asn Arg Gln Leu Thr Leu Cys Asp 
225                 230                 235                 240 


Gly Lys Thr Arg Ser Ile Ala Lys Ala Ala Asp Glu Val Leu Lys Lys 
                245                 250                 255     


His Phe His Glu Leu Trp Glu Asn His Pro Asp Asn His Arg His Met 
            260                 265                 270         


Lys Tyr Tyr Phe Gln Ala Val Lys Glu Tyr Phe Lys Glu Asn Phe Pro 
        275                 280                 285             


Ile Lys Ala Lys Thr Ala Gly Ala Arg Lys Arg Gln Asp Leu Leu Thr 
    290                 295                 300                 


Asp Lys Ala Val Leu Ser Arg Leu Leu Glu Pro Lys His Met Ala Asn 
305                 310                 315                 320 


Val Val Arg Arg Lys Leu Ile Asn Gln Ser Thr Gln Met His Ile Leu 
                325                 330                 335     


Tyr Gly Lys Leu Tyr Glu Tyr Cys Cys Lys Gly Asp Lys Arg Leu Pro 
            340                 345                 350         


Val Asn Ser Asp Thr Leu Gln Arg Ile Gln Val Thr Glu Ala Val Lys 
        355                 360                 365             


Lys Gln Val Met Thr Ala Val Leu Trp Ser Ile Ser Arg Leu Cys Tyr 
    370                 375                 380                 


Phe Tyr Gln Tyr Asp Gly Asp Ile Leu Asn Asp Lys Asn Val Val Asp 
385                 390                 395                 400 


Val Lys Asp Tyr Arg Glu Asn Phe Leu Val Lys Gln Tyr Thr Thr Ala 
                405                 410                 415     


Phe Val Gln Ala Cys Lys Glu Lys Leu Gln Tyr Phe Phe Pro Leu Asp 
            420                 425                 430         


Lys Val Gln Asp Ala Tyr Asn Asp Glu Asn Val Ala Ile Leu Lys Ile 
        435                 440                 445             


Ile Arg Asp Asp Arg Gln Leu Cys Asn Lys Leu Leu Lys Glu Cys Val 
    450                 455                 460                 


Thr Cys Val Lys His Leu Arg Val Asn Ile Phe His Tyr Lys Asn Met 
465                 470                 475                 480 


Gly Phe Ala Gln Thr Leu Lys Lys Ile Ser Ala Glu Ile Glu Asn Glu 
                485                 490                 495     


Leu Asp Lys Ser Thr Ser Ile Leu Leu Trp Leu Tyr Gln Asn Asp Arg 
            500                 505                 510         


Lys Asn Leu Gly Lys Ala Phe Ala Asn Arg Ile Arg Ser Met Asn Leu 
        515                 520                 525             


Pro Leu Tyr Tyr Ser Asn Asp Leu Leu Thr Arg Ile Phe Thr Lys Gln 
    530                 535                 540                 


Gly Leu Glu Phe Ser Leu Tyr Ser Pro Asn Asn Gln Met Thr Pro Ser 
545                 550                 555                 560 


Phe Lys Arg Val Tyr Glu Arg Gly Lys Asn Leu Arg Ser Glu Tyr Glu 
                565                 570                 575     


Arg Arg Leu Ile His Glu Cys Thr Thr Lys Gly His Asp Val Lys Thr 
            580                 585                 590         


Ser Leu Glu Asn Glu Cys Glu Leu Lys Trp Phe Arg Gln Leu Lys Asn 
        595                 600                 605             


Met Thr Val Thr Ser Glu Ser Val Ile Asn Thr Asp Ile Lys Asn Asp 
    610                 615                 620                 


Ile Thr Gly Asn Ile Asp Asn Glu Ser Glu Leu Glu Met Asp Ala Phe 
625                 630                 635                 640 


Phe Glu Ser Glu Thr Tyr Ile Ser Ala Asp Ser Asp Ala Gln Arg Ala 
                645                 650                 655     


Leu Gln Asn Leu Leu Gln Leu Ile Tyr Lys His His Phe Leu Pro Glu 
            660                 665                 670         


Val Met Lys Asp Asp Thr Ile Val Thr Ser Lys Val Ser Lys Val Leu 
        675                 680                 685             


Asp Arg Asn Arg Thr Leu Ala Val Asp Arg Ser Lys Ser Asp Lys Ala 
    690                 695                 700                 


Ser Asp Phe Gly Tyr Arg Ala Val Glu Glu Ile Tyr His Asp Gly Met 
705                 710                 715                 720 


Lys Leu Ser Glu Leu Met Lys Glu Leu Gln Arg Lys Ile Ser Glu Thr 
                725                 730                 735     


Glu Lys Lys Asn Glu Glu Leu Glu Gln Asp Lys Thr Asp Tyr Ala Gln 
            740                 745                 750         


Arg Phe Val Arg Glu Leu Phe Ala Glu Ala Phe Asn Asp Phe Leu Gln 
        755                 760                 765             


Glu Arg Tyr Gly Glu Glu Tyr Tyr Asp Met Met His Pro Gln Arg Asn 
    770                 775                 780                 


Glu Arg Asp Glu Lys Glu Trp Ile Asn Glu Ser Val Asn Leu Arg Thr 
785                 790                 795                 800 


Ser Phe Asp Glu Asn Lys Ile Glu Gly Tyr Leu Leu Val Phe Tyr Thr 
                805                 810                 815     


Val Met Arg Leu Leu Asp Gly Lys Glu Leu Ser Glu Leu Gln Gln Gln 
            820                 825                 830         


Met Leu Arg Phe Arg Ala Ser Met Leu Asn Trp Thr Gly Glu Ala Asp 
        835                 840                 845             


Phe Asp Glu Asp Ile Lys Met Ile Glu Lys Ile Glu Glu Leu Ala Glu 
    850                 855                 860                 


Leu Val Arg Leu Thr Glu Ala Ala Pro Val Tyr Thr Glu Glu Val Trp 
865                 870                 875                 880 


Arg Lys Arg Ala Lys Glu Glu Phe Asn Gln Leu Ile Glu Gly Asp Met 
                885                 890                 895     


Ser Asp Tyr Gly Thr Phe Tyr Leu Gln Thr Asp Gly Ser Ser Pro Val 
            900                 905                 910         


Leu His Arg Ser Met Leu Lys Leu Met Arg Ser Gly Val Met Gly Val 
        915                 920                 925             


Tyr Arg Gln Val Leu His Asp Arg Lys Gln Ala Thr Lys His Asp Tyr 
    930                 935                 940                 


Asn Ile Tyr Cys Asp Arg His Trp Val Leu Met Asp Ser Asp Arg Arg 
945                 950                 955                 960 


Met Val Thr Phe Ala Glu Tyr Ala Gln Arg Ile Leu Gln Glu Leu His 
                965                 970                 975     


Asp Lys Tyr Ala Thr Ser Pro Lys Cys Phe Pro Gln Thr Asp His Arg 
            980                 985                 990         


Ser Tyr Gly Asn Ile Leu Gln Trp  Ile Asp Glu Tyr Asn  His Ala Lys 
        995                 1000                 1005             


Ser Asn  Leu Asn Phe Glu Thr  Leu Tyr Glu Ile Cys  Ser Ile His 
    1010                 1015                 1020             


Met Glu  Ile Leu Ser Arg Trp  Val Gly Phe Val Gln  Asp Trp Glu 
    1025                 1030                 1035             


Arg Asp  Met Tyr Phe Leu Leu  Leu Ala Trp Val Lys  Gln Gly Lys 
    1040                 1045                 1050             


Leu Tyr  Gly Ile Ser Glu Glu  Asp Ile Leu Ser Ile  Phe Glu Lys 
    1055                 1060                 1065             


Gly Lys  Ile Val Ser Lys Leu  Lys Ser Lys Leu Lys  Gly Gly Asn 
    1070                 1075                 1080             


Thr Asn  Ala Phe Phe Ser Ile  Tyr Arg Leu Asp Lys  Asp Lys Glu 
    1085                 1090                 1095             


Thr Asp  Phe Ile Arg Val Arg  Asn Asp Ile Ala His  Leu Asp Leu 
    1100                 1105                 1110             


Leu Arg  Glu Lys Gly Trp Thr  Asp Val Glu Asn Lys  Asp Cys Ser 
    1115                 1120                 1125             


Val Met  Glu Trp Tyr Ile Asn  Arg Leu Arg Ser Leu  Leu Ser Tyr 
    1130                 1135                 1140             


Asp Gln  Lys Arg Met Asn Ala  Val Thr Lys Thr Met  Gln Lys Ile 
    1145                 1150                 1155             


Phe Glu  Arg His Lys Ala Glu  Val Thr Phe Arg Val  Glu Arg Gly 
    1160                 1165                 1170             


Gly Lys  Ile Lys Phe Asp Ser  Val Asn Pro Val Met  Ile Glu His 
    1175                 1180                 1185             


Leu Lys  Glu Phe Lys Gly Ile  Ser Val Pro Ser Arg  Gly Glu Thr 
    1190                 1195                 1200             


Phe Ile  Ser Asn Leu Glu Lys  Leu Met Lys Tyr Ser  Gly Arg 
    1205                 1210                 1215         


<210>  336
<211>  1210
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  336

Met Lys Ile Thr Lys Arg Lys Trp Glu Asp Val Pro Pro Leu Phe Phe 
1               5                   10                  15      


His Arg Asp Lys Asp Ser Gly Arg Leu Ile Arg Gln Asp Asp Arg Glu 
            20                  25                  30          


His Asp Tyr Thr Asp Glu Leu Phe Arg Lys Thr Thr Val Asp Ser Ile 
        35                  40                  45              


Phe Ile Arg Ser Leu Gln Asn Arg Leu Leu Arg Ser Gln Asp Lys Glu 
    50                  55                  60                  


Gly Asn Lys Ile Gly Arg Asn Glu Ile Thr Glu Leu Val Glu Asn Leu 
65                  70                  75                  80  


Cys Lys Gly Ala Glu Ile Gln Lys Ser Ile Asp Glu Ile Lys Asp Ser 
                85                  90                  95      


Lys Ser Asn Val Lys Ala Leu Cys Asp Lys Thr Leu Thr Asp Tyr Gly 
            100                 105                 110         


Lys Ser Phe Ala Ala Glu Glu Gly Arg Thr Thr Leu Tyr Glu Ala Ile 
        115                 120                 125             


Leu Asn Leu Ala Lys Gly Asn Ala Ile Gln Lys Ala Met Ala Glu Ala 
    130                 135                 140                 


Glu Leu Lys Gln Ile His Glu Ala Leu Lys Lys Glu Lys Glu Asp Arg 
145                 150                 155                 160 


Ile Asn Arg Val Gln Asn Ser Ile Lys Asn Asn Lys Ile Pro Leu Lys 
                165                 170                 175     


Val Asn Glu Asp Gly Thr Ile Ser Ala Asn Asn Asp Arg Ala Ser Trp 
            180                 185                 190         


Leu Leu Glu Leu Leu Lys Pro Val Ala Ser Glu His Asp Lys Gly Asp 
        195                 200                 205             


Arg Tyr Pro Val Leu Thr Glu Met Glu Gly Ile Val Ser Phe Asp Lys 
    210                 215                 220                 


Leu Cys Glu Glu Val Arg Asn Lys Ile His Gly Arg Lys Gly Arg Thr 
225                 230                 235                 240 


Arg Ser Ile Ala Met Ser Val Asp Glu Ala Val Lys Glu Tyr Leu Lys 
                245                 250                 255     


Glu Leu Trp Lys Lys His Ala Asp Arg His Arg Asp Met Arg Tyr Tyr 
            260                 265                 270         


Phe Gln Ala Val Lys Glu Tyr Phe Lys Glu Asn Phe Pro Ile Arg Thr 
        275                 280                 285             


Lys Gln Lys Gly Ala Gly Ile Arg Gln Ser Leu Leu Lys Glu Asp Thr 
    290                 295                 300                 


Val Val Ala Arg Leu Leu Asp Pro Lys His Met Ala Lys Ala Val Arg 
305                 310                 315                 320 


Arg Lys Leu Ile Asn Gln Ser Ile Gln Met His Ile Leu Tyr Gly Lys 
                325                 330                 335     


Leu Tyr Glu Tyr Cys Cys Arg Glu Asp Arg Asn Leu Pro Ala Asn Ser 
            340                 345                 350         


Glu Thr Leu Gln Leu Ile Gln Val Leu Glu Ala Phe Lys Lys Gln Leu 
        355                 360                 365             


Met Thr Ala Val Leu Trp Ser Val Ser Arg Leu Cys Tyr Phe Tyr Glu 
    370                 375                 380                 


Phe Tyr Ser Gly Asp Ile Leu Leu Ala Glu Glu Tyr Arg Arg Asp Phe 
385                 390                 395                 400 


Leu Asn Gln Lys Asn Asp His Lys Asp Ile Gln Ala Cys Lys Glu Lys 
                405                 410                 415     


Leu Gln Asp Phe Phe Pro Leu Ala Glu Leu Gln Glu Lys Ile Arg Glu 
            420                 425                 430         


Cys Ala Asp Lys Asp Ile Asn Asn Ile Lys Asp Lys Ile Thr Asn Asp 
        435                 440                 445             


Val Leu Ala Cys Asn Asn Leu Leu Glu Glu Cys Val Phe Cys Ile Ser 
    450                 455                 460                 


Lys Leu Arg Asn Asn Ile Phe His Tyr Lys Asn Leu Ser Phe Thr Gln 
465                 470                 475                 480 


Ala Leu Lys His Ile Ala Asn Glu Asn Lys Glu Glu Asp Ile Pro Ile 
                485                 490                 495     


Ile Leu Arg Leu Tyr Lys Gln Asp Cys Glu Asn Val Asn Lys Ala Phe 
            500                 505                 510         


Ala Asn Arg Ile Ser Ser Met Asn Leu Pro Leu Tyr Tyr Ser Thr Glu 
        515                 520                 525             


Phe Leu Leu Arg Ile Phe Lys Lys Gln Gly Ala Glu Leu Ser Leu Tyr 
    530                 535                 540                 


Ser Thr Lys Asn Gln Met Thr Pro Ser Phe Lys Arg Val Tyr Glu Arg 
545                 550                 555                 560 


Gly Lys Asn Leu Arg Leu Glu Tyr Glu Arg Glu Pro Met Arg Ser Asn 
                565                 570                 575     


Ile Ala Asn Glu Tyr Asp Lys Asp Pro Gln Ser Asp Tyr Trp Met Arg 
            580                 585                 590         


Trp Phe Ser Gln Phe Ala Thr Gly Thr Val Asp Thr Asn Ala Gly Ile 
        595                 600                 605             


Lys Gly Glu Met Glu Asp Tyr Pro His Ala Ser Val Asn Leu Gly Ile 
    610                 615                 620                 


Glu Ile Glu Ala Gly Thr Asn Ile Asp Ala Gln Arg Ala Met Arg Asn 
625                 630                 635                 640 


Leu Leu Gln Leu Ile Tyr Lys His His Phe Leu Pro Glu Val Gln Lys 
                645                 650                 655     


Asp Glu Thr Val Val Thr Asp Val Ile Pro Lys Val Leu Glu Arg Asn 
            660                 665                 670         


Arg Lys Leu Ser Glu Val Arg Asn Arg Ser Asp Lys Thr Tyr Gly Tyr 
        675                 680                 685             


Lys Glu Ile Glu Glu Leu Cys Lys Lys Asn Lys Gly Lys Lys Asp Ser 
    690                 695                 700                 


Leu Ser Glu Leu Met Lys Asp Leu Gln Arg Lys Val Ser Glu Thr Glu 
705                 710                 715                 720 


Lys Glu Lys Arg Glu Leu Ala Arg Glu Lys Thr Asp Tyr Ala Gln Arg 
                725                 730                 735     


Phe Ile Leu Asp Ile Phe Ala Glu Ala Phe Cys Asn Phe Met Asp Glu 
            740                 745                 750         


Arg Tyr Glu Asp Glu Tyr Gln Glu Ile Met Ser Pro Ile Lys Asn Glu 
        755                 760                 765             


Glu Glu Ala Lys Lys Trp Thr Glu Met Phe Thr Asp Lys Ala Asp Lys 
    770                 775                 780                 


Asp Asn Lys Asp Lys Leu Leu Val Leu Lys Thr Ser Phe Asp Lys Asp 
785                 790                 795                 800 


Asn Val Glu Lys Tyr Leu Leu Val Leu Tyr Pro Leu Met Arg Leu Leu 
                805                 810                 815     


Asp Asp Lys Glu Leu Ser Glu Leu Gln Gln Gln Met Leu Arg Phe Arg 
            820                 825                 830         


Ala Ser Val Ser Gly Trp Gln Gly Gly Thr Asp Phe Ser Glu Asp Ile 
        835                 840                 845             


Ala Met Ala Glu Lys Ile Glu Glu Leu Ala Glu Leu Val Lys Leu Thr 
    850                 855                 860                 


Glu Pro Glu Ser Gln Tyr Ala Glu Glu Ala Trp Lys Asn Arg Ala Ile 
865                 870                 875                 880 


Gly Val Phe Glu Gln Phe Val Glu Gly Lys Met Ala Glu Tyr Gly Thr 
                885                 890                 895     


Phe Tyr Ile Gln Asn Asp Ser Leu Thr Gln Val Pro Arg Gly Asn Met 
            900                 905                 910         


Arg Lys Leu Leu Arg Ser Gly Val Ile Gly Val Tyr Asn Lys Val Leu 
        915                 920                 925             


Ala Ser Cys Lys Gln Ala Thr Lys Ala Asp Tyr Gly Ala Tyr Ser Gly 
    930                 935                 940                 


Asp His Trp Ser Ile Glu Asp Pro Asp Gly Asn Pro Ile Lys Ser Ala 
945                 950                 955                 960 


Glu Gln Ala Gln Ala Leu Leu Gln Arg Leu His Lys Lys Tyr Thr Glu 
                965                 970                 975     


Ser Pro Ser Gln Phe Ser Asp Asp Asp His Lys Leu Tyr Asp Lys Thr 
            980                 985                 990         


Leu Arg Gln Leu Asp Ala Tyr Asn  Arg Ala Met Lys Asn  Leu Ser Phe 
        995                 1000                 1005             


Gly Ser  Leu Tyr Glu Ile Cys  Arg Ile His Met Glu  Thr Leu Ser 
    1010                 1015                 1020             


Arg Trp  Val Gly Phe Val Gln  Asp Trp Glu Arg Asp  Met Tyr Phe 
    1025                 1030                 1035             


Leu Leu  Leu Ala Trp Thr Lys  Gln Gly Lys Leu Leu  Asn Val Thr 
    1040                 1045                 1050             


Glu Thr  Asp Val Ile Glu Ile  Phe Glu Lys Gly Ser  Val Ile Tyr 
    1055                 1060                 1065             


Lys Met  Asn Lys Lys Leu Lys  Asn Gly Asp Arg Tyr  Ala Phe Thr 
    1070                 1075                 1080             


Ser Ile  Tyr Arg Asn Asn Asn  Asp Glu Lys Leu Glu  Phe Leu Gln 
    1085                 1090                 1095             


Ile Arg  Asn Phe Ile Ala His  Leu His Leu Leu Arg  Lys Ser Glu 
    1100                 1105                 1110             


Trp Lys  Gly Asp Lys Lys Ala  Gly Tyr Ser Val Ile  Glu Asp Tyr 
    1115                 1120                 1125             


Ile Asn  Lys Leu Arg Phe Leu  Leu Ser Tyr Asp Gln  Lys Arg Met 
    1130                 1135                 1140             


Asn Ala  Val Thr Lys Ala Met  Gln Gln Ile Phe Glu  Lys His Lys 
    1145                 1150                 1155             


Val Ile  Val Lys Phe Met Val  Glu Lys Gly Gly Met  Leu Lys Val 
    1160                 1165                 1170             


Lys Asp  Val Lys Pro Gly Ile  Ile Glu His Leu Lys  Gln Thr Lys 
    1175                 1180                 1185             


Arg Ile  Glu Ile Pro Cys His  Gly Glu Arg Phe Thr  Asp Ser Leu 
    1190                 1195                 1200             


Leu Val  Leu Met Lys Tyr Gln  
    1205                 1210 


<210>  337
<211>  1405
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  337

Leu Phe Leu Trp Ile Ile Glu Glu Ile Ile Tyr Glu Ile Ile Lys Leu 
1               5                   10                  15      


Tyr Lys Asp Leu Lys Glu Glu Ile Ile Met Gly Asn Leu Phe Gly Tyr 
            20                  25                  30          


Lys Arg Trp Tyr Glu Val Arg Asp Lys Glu Asp Tyr Lys Ile Lys Arg 
        35                  40                  45              


Lys Val Lys Val Lys Arg Asn Tyr Asp Gly Asn Lys Tyr Ile Leu Asn 
    50                  55                  60                  


Ile Asn Glu Asn Asn Asn Lys Glu Lys Ile Asp Asp Asn Lys Phe Ile 
65                  70                  75                  80  


Arg Glu Phe Val Asn Tyr Lys Lys Asn Asp Asn Val Leu Arg Glu Phe 
                85                  90                  95      


Lys Arg Lys Phe His Ala Gly Asn Ile Leu Phe Lys Leu Lys Gly Lys 
            100                 105                 110         


Glu Arg Ile Lys Arg Ile Glu Asn Asp Asp Asp Phe Leu Glu Thr Glu 
        115                 120                 125             


Glu Val Val Leu Tyr Ile Glu Val Tyr Gly Lys Ser Glu Lys Leu Lys 
    130                 135                 140                 


Ala Leu Gly Ile Thr Lys Lys Lys Ile Ile Asp Glu Ala Ile Arg Gln 
145                 150                 155                 160 


Gly Ile Thr Lys Asp Asp Lys Lys Ile Glu Ile Lys Arg Gln Lys Ile 
                165                 170                 175     


Glu Ile Asn Ile Arg Asp Lys Tyr Thr Asn Lys Thr Val Asp Asp Cys 
            180                 185                 190         


Ser Val Ile Leu Arg Ile Ile Glu Asn Asp Glu Leu Glu Thr Lys Lys 
        195                 200                 205             


Ser Ile Tyr Glu Ile Phe Lys Asn Ile Asn Met Asn Leu Tyr Lys Ile 
    210                 215                 220                 


Ile Glu Lys Ile Ile Val Asn Lys Thr Glu Lys Val Phe Glu Asn Arg 
225                 230                 235                 240 


Tyr Tyr Glu Glu His Leu Arg Glu Lys Leu Leu Lys Asp Asp Lys Thr 
                245                 250                 255     


Glu Val Ile Leu Thr Asn Phe Met Glu Ile Arg Glu Lys Ile Lys Ser 
            260                 265                 270         


Asn Leu Glu Ile Met Gly Phe Val Lys Phe Tyr Leu Asn Val Gly Gly 
        275                 280                 285             


Asp Lys Lys Lys Ser Glu Asn Lys Lys Ile Phe Val Glu Lys Ile Leu 
    290                 295                 300                 


Asn Ile Asn Val Asp Leu Thr Val Glu Asp Ile Val Asp Phe Ile Val 
305                 310                 315                 320 


Lys Glu Leu Lys Phe Trp Asn Ile Thr Lys Arg Ile Glu Lys Val Lys 
                325                 330                 335     


Glu Phe Asn Asn Lys Ser Leu Glu Asn Lys Arg Asn Arg Thr Tyr Ile 
            340                 345                 350         


Lys Ser Tyr Val Leu Leu Asp Lys His Glu Lys Phe Lys Ile Glu Arg 
        355                 360                 365             


Glu Asn Lys Lys Asp Lys Ile Val Lys Phe Phe Val Glu Asn Ile Lys 
    370                 375                 380                 


Asn Asn Ser Ile Lys Glu Lys Ile Glu Lys Ile Leu Ala Glu Phe Lys 
385                 390                 395                 400 


Ile Asn Glu Leu Ile Lys Lys Leu Glu Lys Glu Leu Lys Lys Gly Asn 
                405                 410                 415     


Cys Asp Thr Glu Ile Phe Gly Ile Phe Lys Lys His Tyr Lys Val Asn 
            420                 425                 430         


Phe Asp Ser Lys Lys Phe Ser Lys Lys Ser Asp Glu Glu Lys Glu Leu 
        435                 440                 445             


Tyr Lys Ile Ile Tyr Arg Tyr Leu Lys Gly Arg Ile Glu Lys Ile Leu 
    450                 455                 460                 


Val Asn Glu Gln Lys Val Arg Leu Lys Lys Met Lys Lys Ile Glu Ile 
465                 470                 475                 480 


Glu Lys Ile Leu Asn Glu Ser Ile Leu Ser Glu Lys Ile Leu Lys Arg 
                485                 490                 495     


Val Lys Gln Tyr Thr Leu Glu Arg Ile Met Tyr Leu Gly Lys Leu Val 
            500                 505                 510         


His Asn Asn Ile Asp Met Thr Thr Val Asn Thr Asn Asp Phe Ser Met 
        515                 520                 525             


Leu His Ala Lys Glu Glu Leu Asp Leu Glu Leu Ile Thr Phe Phe Ala 
    530                 535                 540                 


Ser Thr Asn Met Glu Leu Asn Lys Ile Phe Ser Arg Lys Asn Ile Asn 
545                 550                 555                 560 


Asn Asp Gly Asn Ile Asp Phe Phe Gly Gly Asp Gly Glu Lys Asn Tyr 
                565                 570                 575     


Ile Leu Asp Lys Lys Ile Ser Asn Ser Lys Ile Glu Ile Ile Arg Lys 
            580                 585                 590         


Leu Asp Phe Ile Asp Asn Lys Asn Asp Ile Thr Asn Asn Phe Ile Glu 
        595                 600                 605             


Lys Phe Ile Lys Ile Gly Thr Asn Glu Arg Asn Arg Ile Leu His Ala 
    610                 615                 620                 


Asn Asn Lys Gly Arg Glu Ile Gln Glu Ala Lys Asp Asn Tyr Gly Lys 
625                 630                 635                 640 


Val Thr Lys Ile Ile Glu Asp Leu Lys Ile Ser Asp Glu Glu Val Ser 
                645                 650                 655     


Lys Ala Leu Asn Leu Asp Val Val Phe Lys Asp Lys Lys Asn Ile Ile 
            660                 665                 670         


Thr Lys Ile Asn Asp Ile Lys Ile Ser Glu Glu Asn Asn Asn Asp Ile 
        675                 680                 685             


Lys Tyr Leu Pro Ser Phe Ser Lys Val Leu Pro Glu Ile Leu Asn Leu 
    690                 695                 700                 


Tyr Arg Asn Asn Pro Lys Asn Glu Pro Phe Asp Thr Ile Glu Thr Glu 
705                 710                 715                 720 


Lys Ile Val Leu Asn Ala Leu Ile Tyr Val Asn Lys Glu Leu Tyr Lys 
                725                 730                 735     


Lys Leu Ile Leu Glu Asp Asp Leu Glu Glu Asn Gly Ser Lys Asn Ile 
            740                 745                 750         


Phe Leu Gln Glu Leu Lys Lys Thr Leu Gly Asn Ile Asp Glu Ile Asp 
        755                 760                 765             


Glu Asn Ile Ile Glu Asn Tyr Tyr Lys Asn Ala Gln Ile Ser Ala Ser 
    770                 775                 780                 


Lys Gly Asn Asn Lys Ala Ile Lys Lys Tyr Gln Lys Lys Val Ile Glu 
785                 790                 795                 800 


Cys Tyr Ile Gly Tyr Leu Arg Lys Asn Tyr Glu Glu Leu Phe Asp Phe 
                805                 810                 815     


Ser Asp Phe Lys Met Asn Ile Gln Glu Ile Lys Lys Gln Ile Lys Asp 
            820                 825                 830         


Ile Asn Asp Asn Lys Thr Tyr Glu Arg Ile Thr Val Lys Thr Ser Asp 
        835                 840                 845             


Lys Thr Ile Val Ile Asn Asp Asp Phe Glu Tyr Ile Ile Ser Ile Phe 
    850                 855                 860                 


Ala Leu Leu Asn Ser Asn Ala Val Ile Asn Lys Ile Arg Asn Arg Phe 
865                 870                 875                 880 


Phe Ala Thr Ser Val Trp Leu Asn Thr Ser Glu Tyr Gln Asn Ile Ile 
                885                 890                 895     


Asn Ile Leu Asp Glu Ile Met Gln Leu Asn Thr Leu Arg Asn Glu Cys 
            900                 905                 910         


Ile Thr Glu Asn Trp Asn Leu Asn Leu Glu Glu Phe Ile Gln Lys Met 
        915                 920                 925             


Leu Asp Val Glu Lys Glu Ile Gly Asn Phe Glu Ile Lys Thr Lys Lys 
    930                 935                 940                 


Glu Ile Phe Asp Ile His Tyr Glu Glu Ile Lys Asn Asp Met Ile Val 
945                 950                 955                 960 


Lys Ile Asn Asp Asn Lys Ile Gln Lys Ile Leu Asn Lys Cys Leu Lys 
                965                 970                 975     


Glu Ile Thr Gly Phe Ser Ser Asn Asn Glu Tyr Met Phe Lys Asn Leu 
            980                 985                 990         


Gly Lys Leu Thr Leu Glu Glu Arg  Asp Phe Ile Leu Ser  Asn Lys Lys 
        995                 1000                 1005             


Leu Ile  Glu Lys Asn Ile Asp  Glu Ile Ile Gly Glu  Lys Leu Asp 
    1010                 1015                 1020             


Ala Ile  Lys Glu Lys Val Leu  Leu Lys Lys Val Phe  Asn Ser Glu 
    1025                 1030                 1035             


Phe Leu  Glu Lys Tyr Lys Glu  Glu Ile Asp Asn Leu  Val Glu Asp 
    1040                 1045                 1050             


Thr Glu  Ser Glu Asn Lys Asn  Lys Phe Glu Lys Ile  Tyr Tyr Pro 
    1055                 1060                 1065             


Lys Glu  His Lys Asn Glu Leu  Tyr Ile Tyr Lys Lys  Asn Leu Phe 
    1070                 1075                 1080             


Leu Asn  Ile Gly Asn Pro Asn  Phe Asp Lys Ile Tyr  Gly Ile Ile 
    1085                 1090                 1095             


Ser Lys  Asp Ile Lys Asn Ala  Asn Thr Glu Ile Leu  Phe Asp Asp 
    1100                 1105                 1110             


Asp Ile  Arg Lys Asn Lys Ile  Ser Lys Ile Asp Ala  Ile Leu Lys 
    1115                 1120                 1125             


Asn Leu  Asn Asp Lys Leu Asn  Gly Tyr Ser Asn Asp  Tyr Lys Ala 
    1130                 1135                 1140             


Lys Tyr  Val Asn Lys Leu Lys  Glu Asn Asp Asp Phe  Phe Ala Lys 
    1145                 1150                 1155             


Asn Ile  Gln Asn Glu Asn Tyr  Ser Ser Leu Gly Glu  Phe Glu Lys 
    1160                 1165                 1170             


Asp Tyr  Asn Lys Val Ser Glu  Tyr Lys Lys Ile Arg  Asp Leu Val 
    1175                 1180                 1185             


Glu Phe  Asn Tyr Leu Asn Lys  Ile Glu Ser Tyr Leu  Ile Asp Ile 
    1190                 1195                 1200             


Asn Trp  Lys Leu Ala Ile Gln  Met Ala Arg Phe Glu  Arg Asp Met 
    1205                 1210                 1215             


His Tyr  Ile Val Ser Gly Leu  Asn Tyr Leu Tyr Ile  Ile Arg Leu 
    1220                 1225                 1230             


Glu Lys  Asp Arg Asn Gln Asp  Arg Ser Ser Pro Tyr  Pro Lys Tyr 
    1235                 1240                 1245             


Lys Asn  Gly Val Leu Asp Tyr  Thr Lys Ser Tyr Tyr  Asn Phe Lys 
    1250                 1255                 1260             


Asp Tyr  Gln Glu Phe Met Asp  Ile Cys Leu Lys Phe  Gly Ile Asn 
    1265                 1270                 1275             


Leu Ser  Glu Asn Ser Glu Ile  Asn Lys Pro Glu Asn  Glu Ser Ile 
    1280                 1285                 1290             


Arg Asn  Tyr Ile Ser His Phe  Tyr Ile Val Arg Asn  Pro Phe Ala 
    1295                 1300                 1305             


Asp Tyr  Ser Ile Ala Glu Gln  Ile Asp Arg Val Ser  Asn Leu Leu 
    1310                 1315                 1320             


Ser Tyr  Ser Thr Arg Tyr Asn  Asn Ser Thr Tyr Ala  Ser Val Phe 
    1325                 1330                 1335             


Glu Val  Phe Lys Lys Asp Val  Asp Leu Asp Tyr Asp  Glu Leu Lys 
    1340                 1345                 1350             


Lys Lys  Phe Lys Leu Ile Gly  Asn Asn Asp Ile Leu  Glu Arg Leu 
    1355                 1360                 1365             


Met Lys  Pro Lys Lys Val Ser  Val Leu Glu Leu Glu  Ser Tyr Asn 
    1370                 1375                 1380             


Ser Asn  Tyr Val Lys Asn Leu  Ile Ile Lys Leu Leu  Thr Lys Ile 
    1385                 1390                 1395             


Glu Lys  Thr Asn Asp Lys Leu  
    1400                 1405 


<210>  338
<211>  1135
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  338

Met Lys Ile Thr Lys Ile Gly Gly Ile Ser His Lys Lys Tyr Glu Glu 
1               5                   10                  15      


Lys Gly Lys Leu Ile Lys Ser Asn Glu Ile Glu Lys Asp Val Ile Glu 
            20                  25                  30          


Glu Arg Phe Ser Asn Ile Glu Ala Lys Thr Thr Glu Leu Phe Ser Lys 
        35                  40                  45              


Thr Leu Asp Phe Tyr Val Lys Asn Tyr Glu Lys Cys Glu Glu Gln Asn 
    50                  55                  60                  


Lys Glu Arg Arg Glu Lys Ala Lys Asn Tyr Phe Ser Lys Val Lys Leu 
65                  70                  75                  80  


Ile Val Asp Asn Lys Lys Ile Thr Ile Phe Asn Glu Asn Thr Glu Lys 
                85                  90                  95      


Ile Glu Ile Glu Gly Phe Asn Glu Tyr Asp Val Arg Asp Glu Lys Tyr 
            100                 105                 110         


Phe Asn Val Leu Asn Lys Ile Leu Lys Glu Glu Asn Cys Thr Glu Glu 
        115                 120                 125             


Asp Leu Glu Val Phe Glu Asn Asp Leu Gln Lys Lys Leu Asn Gln Ile 
    130                 135                 140                 


Gln Ser Ile Lys Asn Ser Leu Glu Lys Asn Lys Ala His Phe Lys Lys 
145                 150                 155                 160 


Glu Ser Ile Asn Asn Thr Thr Asp Arg Val Lys Gly Asn Asn Lys Lys 
                165                 170                 175     


Ser Leu Phe Tyr Glu Tyr Tyr Arg Asn Ser Ser Lys His Gln Glu Tyr 
            180                 185                 190         


Val Asn Asn Ile Phe Glu Ala Phe Asp Lys Leu Tyr Ser Asn Ser His 
        195                 200                 205             


Glu Asp Ile Asn Asn Leu Phe Leu Glu Ile Thr Lys Asp Ser Asn Asn 
    210                 215                 220                 


Arg Asn Ile Arg Lys Ile Arg Glu Val Tyr Asn Glu Ile Leu Asn Lys 
225                 230                 235                 240 


Asn Lys Thr Glu Phe Gly Glu Glu Leu Tyr Lys Lys Ile Gln Asp Asn 
                245                 250                 255     


Ile Ser Asn Phe Asp Lys Leu Leu Glu Ile Glu Pro Glu Ile Lys Glu 
            260                 265                 270         


Leu Thr Lys Ser Gln Ile Phe Tyr Lys Tyr Tyr Ile Asp Lys Val Ser 
        275                 280                 285             


Leu Asp Gly Thr Asn Ile Lys His Cys Phe Ser His Leu Val Glu Ile 
    290                 295                 300                 


Glu Val Asn Gln Leu Leu Lys Asn Tyr Val Tyr Ser Lys Arg Ser Thr 
305                 310                 315                 320 


Asn Lys Glu Lys Leu Glu Asn Ile Phe Glu Tyr Cys Lys Leu Arg Asn 
                325                 330                 335     


Leu Val Lys Asn Lys Leu Val Asn Lys Leu Asn Asn Tyr Ile Arg Asn 
            340                 345                 350         


Cys Gly Lys Tyr Asn Ser Tyr Ile Asn Asn Asn Asp Val Val Asn Ser 
        355                 360                 365             


Glu Lys Ile Ser Glu Ile Arg Thr Lys Glu Ala Phe Leu Arg Ser Ile 
    370                 375                 380                 


Ile Gly Val Ser Ser Ser Ala Tyr Phe Ser Leu Arg Asn Ile Leu Asn 
385                 390                 395                 400 


Thr Asp Asn Thr Gln Asp Ile Thr Asn Lys Val Lys Gly Glu Val Glu 
                405                 410                 415     


Lys Leu Tyr Gln Glu Asn Lys Lys Val Lys Leu Glu Glu Arg Leu Lys 
            420                 425                 430         


Leu Phe Phe Gly Asn Asn Phe Asp Ile Asn Asn Gln Gln Glu Ile Glu 
        435                 440                 445             


Asp Phe Leu Met Asn Ile Asp Lys Ile Ile Ser Asn Ile Arg His Glu 
    450                 455                 460                 


Ile Ile His Phe Lys Ile Glu Ala Asn Ala His Ser Ile Phe Asp Phe 
465                 470                 475                 480 


Asn Asn Val Thr Leu Gly Asn Lys Ala Lys Asn Ile Phe Asn Asn Glu 
                485                 490                 495     


Ile Asn Glu Glu Arg Ile Lys Phe Lys Ile Phe Lys Gln Leu Asn Ser 
            500                 505                 510         


Ala Asn Val Phe Asp Tyr Leu Ser Asp Glu Asn Ile Thr Glu Tyr Met 
        515                 520                 525             


Gly Lys Val Ile Phe Ser Phe Thr Asn Arg Asn Ile Pro Phe Val Pro 
    530                 535                 540                 


Ser Phe Arg Lys Ile Tyr Asn Arg Val Gln Asp Leu Ala Asn Ser Leu 
545                 550                 555                 560 


Lys Ile Lys Glu Trp Lys Ile Ser Asp Glu Ser Glu Gly Lys Asp Ala 
                565                 570                 575     


Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asp Asp 
            580                 585                 590         


Phe Leu Asn Glu Lys Asn Glu Lys Phe Ile Lys Ile Lys Asp Glu Ile 
        595                 600                 605             


Ile Glu Leu Asn Lys Asn Gln Asn Lys Ile Thr Gly Phe Tyr Lys Leu 
    610                 615                 620                 


Glu Lys Phe Glu Lys Ile Glu Glu Lys Asn Pro Lys Lys Tyr Leu Glu 
625                 630                 635                 640 


Ile Ile Gln Ser Leu Tyr Met Ile Asn Ile Glu Glu Ile Asp Asn Glu 
                645                 650                 655     


Glu Lys Asn Ile Phe Leu Asp Phe Ile Gln Lys Ile Phe Leu Lys Gly 
            660                 665                 670         


Phe Phe Glu Phe Ile Lys Asn Asn Tyr Asn Tyr Leu Leu Glu Leu Lys 
        675                 680                 685             


Lys Ile Gln Asp Lys Lys Asn Ile Phe Asp Arg Glu Met Ser Glu Tyr 
    690                 695                 700                 


Ile Ala Gly Glu Lys Thr Leu Glu Asp Ile Gly Glu Ile Asn Glu Ile 
705                 710                 715                 720 


Ile Gln Lys Ile Glu Ile Thr Lys Ile Asp Lys Ile Leu Asn Leu Thr 
                725                 730                 735     


Asp Lys Ile Asn Cys Phe Tyr Leu Leu Leu Lys Leu Leu Asn Tyr Lys 
            740                 745                 750         


Glu Ile Thr Glu Leu Lys Gly Asn Leu Glu Lys Tyr Gln Ile Leu Ser 
        755                 760                 765             


Lys Thr Asp Ile Tyr Glu Lys Glu Leu Ile Leu Leu Asn Ile Val Asn 
    770                 775                 780                 


Leu Asp Asn Asn Lys Val Lys Ile Glu Lys Phe Lys Ile Ser Ala Glu 
785                 790                 795                 800 


Glu Ile Gly Lys Phe Ile Glu Lys Ile Ser Arg Asn Lys Lys Ile Lys 
                805                 810                 815     


Thr Phe Glu Glu Leu Arg Asn Phe Glu Lys Arg Glu Asn Thr Gly Glu 
            820                 825                 830         


Tyr Tyr Asn Val Tyr Ser Asp Asp Lys Asn Ile Lys Asn Ile Arg Asn 
        835                 840                 845             


Leu Tyr Asn Ile Lys Lys Tyr Gly Met Leu Asp Leu Leu Glu Arg Ile 
    850                 855                 860                 


Ser Glu Lys Ser Asn Tyr Cys Ile Lys Lys Glu Asp Leu Lys Glu Tyr 
865                 870                 875                 880 


Asp Lys Leu Lys Lys Lys Leu Glu Asp Lys Lys Thr Asp Phe Tyr Lys 
                885                 890                 895     


Ile Gln Lys Asp Leu His Tyr Lys Tyr Gln Lys Glu Tyr Lys Asn Phe 
            900                 905                 910         


Ser Lys Lys Asn Asn Thr Glu Asp Tyr Glu Lys Tyr Lys Glu Ser Ile 
        915                 920                 925             


Glu Asn Ile Glu Lys Tyr Val His Leu Lys Asn Lys Ile Glu Phe Asn 
    930                 935                 940                 


Glu Leu Asn Leu Leu Gln Ser Leu Leu Leu Lys Ile Leu His Arg Leu 
945                 950                 955                 960 


Val Gly Phe Thr Ser Ile Trp Glu Arg Asp Leu Arg Phe Arg Leu Ile 
                965                 970                 975     


Gly Glu Phe Pro Asp Glu Leu Asp Val Glu Asp Ile Phe Asp His Arg 
            980                 985                 990         


Glu Arg Tyr Arg Gly Thr Arg Gly  Gln Ile Cys Lys Lys  Tyr Asp Gln 
        995                 1000                 1005             


Phe Ile  Ser Val His Ile Glu  Tyr Gln Asn Asn Lys  Lys Met Lys 
    1010                 1015                 1020             


Asn Ile  Lys Phe Asp Asp Asn  Asn Pro Ile Arg Asn  Tyr Ile Ala 
    1025                 1030                 1035             


His Phe  Asn Tyr Leu Pro Thr  Pro Lys Tyr Ser Ile  Leu Lys Met 
    1040                 1045                 1050             


Leu Gly  Lys Leu Arg Glu Leu  Leu Asp Tyr Asp Arg  Lys Leu Lys 
    1055                 1060                 1065             


Asn Ala  Val Met Lys Ser Ile  Lys Asp Ile Leu Glu  Glu Tyr Gly 
    1070                 1075                 1080             


Phe Lys  Ala Glu Phe Val Ile  Asn Pro Asp Lys Glu  Ile Ile Leu 
    1085                 1090                 1095             


Asn Ser  Val Lys Ser Val Glu  Ile Ile His Leu Lys  Lys Asn Asp 
    1100                 1105                 1110             


Leu Asn  Ser His Arg Asn Ser  Glu Asp Leu Cys Lys  Leu Val Lys 
    1115                 1120                 1125             


Ala Met  Leu Glu Tyr Ser Glu  
    1130                 1135 


<210>  339
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  339

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Gly Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  340
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  340

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Thr Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  341
<211>  1330
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  341

Met Lys Arg Glu Lys Asn Ile Thr Ile Met Lys Ile Ser Lys Val Asn 
1               5                   10                  15      


His Arg Arg Thr Ala Val Ala Leu Asn Gly Asp Lys Ser Glu Leu Gly 
            20                  25                  30          


Gly Ile Leu Tyr Glu Ala Pro Val Gln Lys Asp Lys Asn Gly Asn Tyr 
        35                  40                  45              


Asn Asp Val Ile Ala Glu Thr Gly Lys Val Val Asn Glu Ala Leu Asp 
    50                  55                  60                  


Lys Lys Ser Arg Leu Tyr Thr Pro Phe Asn Asn Gln Lys Val Ile Ile 
65                  70                  75                  80  


Asp Lys Asn Leu Gln Arg Tyr Ala Asn Asn Leu Lys Arg Cys Tyr Ile 
                85                  90                  95      


Asn Phe Val Lys Gln Tyr Val Asn Asn Lys Ser Phe Asn Tyr Lys Ala 
            100                 105                 110         


Met Gln Phe Ile Pro Asp Ile Gln Asn Pro Lys Thr Asn Asp Ala Val 
        115                 120                 125             


Asn Tyr Arg Thr Asp Arg Asp Asn Val Tyr Asn Lys Asn Lys Tyr Tyr 
    130                 135                 140                 


Asp Lys Gln Thr Lys Ser Lys Ser Lys Lys Phe Ile Tyr Glu Lys Ile 
145                 150                 155                 160 


Val Ile Pro Gln Asn Glu Gln Asn Ile Val Ile Ser Ala Leu Val Asn 
                165                 170                 175     


Cys Ser Leu Arg Lys Ser Leu Arg Lys Asp Val Ser Tyr Lys Thr Lys 
            180                 185                 190         


Ser Gly Glu Ile Lys Thr Tyr Asn Leu Pro Glu Leu Val Lys Lys Ser 
        195                 200                 205             


Met Arg Phe Tyr Cys Leu Glu Gly Gln Arg Glu Pro Asp Glu Lys Glu 
    210                 215                 220                 


Lys Tyr Glu Met Tyr Ile Leu Phe Ser Tyr Met Lys Glu Asp Lys Arg 
225                 230                 235                 240 


Thr Lys Asn Thr Asp Leu Leu Val Lys Ser Ile Ser Asn Gln Asn Thr 
                245                 250                 255     


Lys Val Lys Val Glu Asp Ile Asp Gly Asn Lys Leu Leu Lys Leu Ser 
            260                 265                 270         


Ile Ala Asp Thr Lys Lys Lys Leu Leu Trp Glu Tyr Leu Ile Lys Tyr 
        275                 280                 285             


Ala Asp Ser Ser Arg Gln Arg Glu Leu Met Tyr Asp Ile Arg Lys Lys 
    290                 295                 300                 


Ile Ile Leu Tyr Val Ala Gly Ile Glu Glu Tyr Glu Asn Ile Lys Glu 
305                 310                 315                 320 


Asp Ser Gly Leu Ser Lys Val Ser Trp Ser Lys Tyr Asn Ile Ser Asp 
                325                 330                 335     


Asn Lys Met Phe Phe Asp Ile Asn Ser Cys Thr Asp Lys Arg Lys Gln 
            340                 345                 350         


Asn Leu Glu Ile Lys Ile Arg Glu Ala Asn Ile Glu His Tyr Arg Asn 
        355                 360                 365             


Ala Ser Ser Lys Leu Cys Asp Asp Glu Ser Ile Phe Trp Phe Gln His 
    370                 375                 380                 


Phe Glu Gly Val Ile Glu Thr Leu Phe Ser Lys Lys Ser Lys Ile Ser 
385                 390                 395                 400 


Glu Glu Arg Leu Gly Cys Ala Tyr Ile Cys Asp Tyr Leu Trp Lys Asp 
                405                 410                 415     


Phe Leu Ser Tyr Leu Ala Ala Lys Tyr Ile Asp Leu Gly Lys Gly Val 
            420                 425                 430         


Tyr His Phe Thr Met Lys Asp Lys Leu Asp Met Leu Asn Lys Asn Glu 
        435                 440                 445             


Ala Val Thr Asp Leu Arg Phe Gly Ile Val Ser Glu Lys Tyr Glu Lys 
    450                 455                 460                 


Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Glu Leu 
465                 470                 475                 480 


Asp Arg Asn Ile Ala Ala Tyr Val Thr Phe Ala Ala Asp Ile Phe Ala 
                485                 490                 495     


Lys Ser Val Ile Lys Ser Asp Tyr Arg Thr Lys Lys Asp Asn Asn Ser 
            500                 505                 510         


Asp Val Leu Gln Tyr Ser Asp Lys Glu Phe Arg Asn Ser Glu Val Ile 
        515                 520                 525             


Arg Asp Asn Ala Glu Lys Asn Ile Leu Gln Tyr Trp Gly Gly Tyr Ser 
    530                 535                 540                 


Arg Trp Cys Thr Glu Asn Ser Lys Leu Pro Glu Asn Asn Lys Val Ser 
545                 550                 555                 560 


Asp Phe Gly Lys Leu Asp Val Ser Asp Leu Cys Ile Asp Ile Lys Lys 
                565                 570                 575     


His Leu Ala Gly Ile Arg Asn Ser Ser Val His Tyr Thr Thr Lys Ile 
            580                 585                 590         


Lys Asn Glu Ser Ala Ala Asp Gly Ser Asn Val Lys Ile Leu Phe Glu 
        595                 600                 605             


Lys Asp Leu Ala Asp Ile Asn Ile Ile Tyr Ala Asp Lys Tyr Tyr Ser 
    610                 615                 620                 


Asn Asn Val Trp Met Phe Tyr Ser Leu Glu Asp Ile Asn Lys Leu Ile 
625                 630                 635                 640 


Ala Phe Leu Tyr Lys Glu Lys Arg Val Ile Arg Gln Val Gln Ile Pro 
                645                 650                 655     


Ser Phe Ser Arg Ile Leu Lys Arg Lys Ala Met Gln Asp Val Ile Asn 
            660                 665                 670         


Glu Ile Phe Lys Asp Asp Phe Asp Glu Asn Ile Val Asn Pro Glu Leu 
        675                 680                 685             


Lys Glu Lys Tyr Arg Asn Ser Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
    690                 695                 700                 


Tyr Asn Ala Phe Ile Ile Gln Pro Glu Leu Lys Glu Lys Phe Lys Asp 
705                 710                 715                 720 


Lys Ile Lys Thr Met Lys Ser Glu Leu Tyr Asn Lys Leu Lys Thr Ile 
                725                 730                 735     


Asp Lys Lys Glu Tyr Lys Ala Leu Tyr Cys Met Leu Ser Asn Glu Glu 
            740                 745                 750         


Ser Ala Leu Lys Asn Phe Ala Asp Arg Ile Tyr Ser Val Asp Gly Asp 
        755                 760                 765             


Asn Val Ser Phe Ala Asp Ile Cys Lys Ile Leu Met Thr Asp Tyr Asn 
    770                 775                 780                 


Met Gln Asn Gln Glu Lys Lys Asn Ile Glu Ser Met Glu Gln Lys Lys 
785                 790                 795                 800 


Lys Asn Lys Gly Lys Asp Glu Asn Tyr Lys His Phe Pro Leu Leu Leu 
                805                 810                 815     


His Lys Val Leu Lys Glu Leu Phe Ile Glu Tyr Leu Lys Gln Thr His 
            820                 825                 830         


Glu Leu Glu Phe Leu Arg Asn Asn Ile Cys Ile Lys Ser Asp Val Thr 
        835                 840                 845             


Met Glu Ser Phe Glu Ser Gln Ile Lys Gly Val Glu Ile Tyr Lys Asp 
    850                 855                 860                 


Leu Lys Glu Lys Ile Asp Lys Asn Asn Ser Leu Leu Asp Trp Tyr Val 
865                 870                 875                 880 


Ile Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asn 
                885                 890                 895     


Ile Lys Asn Tyr Ile Gln Phe Ala Thr Asn Ile Asp Lys Arg Ala Glu 
            900                 905                 910         


Ser Val Lys Asn Leu Thr Glu Ser Gly Met Val Lys Arg Ile Gln Tyr 
        915                 920                 925             


Tyr Asp Asp Ile Val Arg Thr Leu Glu Phe Ser Ala Gln Tyr Ile Gly 
    930                 935                 940                 


Lys Ile Ser Asn Asn Ile Asn Asp Tyr Phe Asn Ser Glu Asp Glu Tyr 
945                 950                 955                 960 


Val Ser Phe Leu Ser Lys Tyr Val Gly Phe Ile Asn Asp Lys Ser Glu 
                965                 970                 975     


Asp Val Leu Thr Glu Leu Lys Asp Phe Cys Arg Glu Lys Ile Asn Asn 
            980                 985                 990         


Gly Ser Gln Ile Ile Gly Ile Tyr  Tyr Gly Gly Asp Asn  Val Ile Ile 
        995                 1000                 1005             


Asn Arg  Asn Val Ile Tyr Ala  Gln Met Tyr Ser Asn  Ala Glu Val 
    1010                 1015                 1020             


Phe Ser  Asn Ile Tyr Lys Lys  Val Thr Lys Asn Asp  Ile Ile Asn 
    1025                 1030                 1035             


Tyr Tyr  Glu Lys Gln Asn Asp  Leu Lys Asp Val Phe  Lys Ser Gly 
    1040                 1045                 1050             


Val Cys  Gln Asn Glu Asp Glu  Gln Arg Ser Leu Cys  Glu Phe Gln 
    1055                 1060                 1065             


Gln Leu  Lys Asn Arg Ile Glu  Leu Thr Glu Leu Ser  Thr Tyr Ala 
    1070                 1075                 1080             


Asp Met  Val Asn Asp Phe Met  Ala Gln Phe Val Glu  Trp Ala Tyr 
    1085                 1090                 1095             


Leu Arg  Glu Arg Asp Leu Met  Tyr Phe Gln Leu Gly  Ile His Tyr 
    1100                 1105                 1110             


Ile Arg  Leu Phe Tyr Ser Asp  Asn Val Leu Asp Glu  Lys Tyr His 
    1115                 1120                 1125             


Lys Leu  Ser Asp Asn Val Ile  Asp Ile Glu Glu Gly  Ala Leu Leu 
    1130                 1135                 1140             


Tyr Gln  Ile Val Ala Met Tyr  Asp Tyr Glu Leu Arg  Ile Phe Glu 
    1145                 1150                 1155             


Thr Asp  Asn Ser Gly Asn Ala  Lys Arg Ile Gly Gln  Gly Gly Pro 
    1160                 1165                 1170             


Gly Lys  Ser Ile Pro Val Phe  Leu Lys Lys Tyr Cys  Ser Gly Thr 
    1175                 1180                 1185             


Asp Val  Tyr Glu Cys Gly Leu  Glu Leu Phe Glu Asp  Ile Asn Gln 
    1190                 1195                 1200             


His Glu  His Ile Ile Arg Phe  Arg Asn Asp Ile Ala  His Met Arg 
    1205                 1210                 1215             


Tyr Met  Ser Asn Gln Ala Met  Asn Ile Met Ser Ile  Val Ser Asn 
    1220                 1225                 1230             


Ile Tyr  Lys Ser Phe Phe Ala  Tyr Asp Thr Lys Leu  Lys Lys Ser 
    1235                 1240                 1245             


Ile Ser  Leu Val Phe Lys Asn  Ile Leu Met Arg Tyr  Gly Val Ile 
    1250                 1255                 1260             


Ala Asp  Leu Val Phe Ser Tyr  Asn Asn Lys Asn Gln  Ser Ile Lys 
    1265                 1270                 1275             


Asp Asp  Met Asp Ile Asn Ile  Ile Asn Ile Lys Asn  Leu Lys Ser 
    1280                 1285                 1290             


Asp Lys  Tyr Val Tyr Lys Ile  Val Asn Glu Asp Ile  Val Lys Gln 
    1295                 1300                 1305             


Val Glu  Ile Glu Ile Arg Asn  Gln Val Phe Leu Glu  Gln Leu His 
    1310                 1315                 1320             


Asn Leu  Leu Tyr Phe Ser Arg  
    1325                 1330 


<210>  342
<211>  1208
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  342

Met Gln Ile Ile Lys Pro Tyr Gly Arg Ser Phe Thr Glu Thr Asn Gln 
1               5                   10                  15      


Arg Val Leu Leu Asp Lys His Arg Asp Lys His Asp Ile Ser Pro Phe 
            20                  25                  30          


Ala Ala Ser His Glu Lys Leu Val Ile Ala Gln Trp Val Ser Val Ile 
        35                  40                  45              


Asp Lys Ile Val Arg Lys Pro Asn Pro Lys Ala Lys Ile Ser Leu Pro 
    50                  55                  60                  


Thr Pro Gln Gln Tyr Gln Leu Arg Glu Thr Leu Gly Asn Ala Ala Trp 
65                  70                  75                  80  


Leu Glu Leu Asn Lys Arg Leu Pro Cys Ser Asp His Ala Val Phe Trp 
                85                  90                  95      


Arg Ser Lys Ile His Pro Tyr Gly His Ala Thr Gln Glu Gln Glu Pro 
            100                 105                 110         


Ala Pro Leu Leu Gln Gly Arg Trp Tyr Gln Arg Phe Val Gly Asp Ile 
        115                 120                 125             


Glu Pro Thr Ala Ile Thr Glu Asn Val Ala Gln Ile Ile Ala Glu Arg 
    130                 135                 140                 


Ile Ala Ser His Leu Tyr Glu Ala Glu Leu Arg Leu Ser Pro Glu Ala 
145                 150                 155                 160 


Glu Pro Arg Gly Lys Gly Lys Ile Gln Ala Gln Ala Glu Ser Ile Glu 
                165                 170                 175     


Lys Asn Thr Leu His Gln Pro Lys Leu Ser Ala Thr Trp Cys Asp Ala 
            180                 185                 190         


Asp Trp Thr Ala Tyr Asn Arg His Asp Val Ala Glu Arg Ile Tyr Leu 
        195                 200                 205             


Glu Ala Lys Phe Arg Leu Glu Gln Lys Gln Glu Ala Arg Lys Asn Lys 
    210                 215                 220                 


Gln Pro Met Gln Leu Glu Trp Arg Ile Asp Arg Ser Leu Thr Gly Lys 
225                 230                 235                 240 


Ile Leu Phe Glu His Trp Ala Lys Val Tyr Ser Gly Thr Asp Gly Lys 
                245                 250                 255     


Ser Arg Ile Thr Glu Ala Lys Gln Glu Lys Pro Gly Leu Phe His Leu 
            260                 265                 270         


His Met Ala Val Lys Asp Phe Tyr Thr Arg Leu Phe Asp Arg Asp Arg 
        275                 280                 285             


Arg Asp Glu Thr Leu Val Glu Phe Leu Leu Pro Arg Lys Lys Lys Ala 
    290                 295                 300                 


Leu Arg Glu Lys Leu Glu Gln Lys Ser Lys Asn Thr Asp Leu Ala Ala 
305                 310                 315                 320 


Ser Ile Arg Leu Gly Lys Ile Leu Tyr Tyr Arg Glu Ala Glu Ser Glu 
                325                 330                 335     


Thr Val Pro Leu Ala Asn Ser Arg Phe Trp Gly Ser Glu Gly Gln Ala 
            340                 345                 350         


Glu Ile Lys Arg Ala Glu Ala Phe Val Arg Val Trp Arg His Val Leu 
        355                 360                 365             


Gly Gln Ser Asn Leu Thr Leu Ala Asn Trp Ala Ser Leu Ala Ser Pro 
    370                 375                 380                 


Asp Glu Leu Trp Glu Lys Asp Ser Phe Asp Ser Lys Phe Leu Asp His 
385                 390                 395                 400 


Val Glu Lys Leu Phe Ala Lys Asp Asn Gly Leu Asp Lys Arg Arg Gln 
                405                 410                 415     


Glu Phe Asp Gln Asn Leu Asn Leu Leu Leu Gly Asp Gly Ala Ser Ala 
            420                 425                 430         


Phe Met Ala Asp Asp Asp Ser Arg Gln Ala Ala Ile Arg Leu Ala Tyr 
        435                 440                 445             


Asp Val Gly Ser Ala Leu Arg His Ala Ala Phe His Phe Lys Gly Arg 
    450                 455                 460                 


Asp Lys Phe Leu Glu Val Leu Asp Lys Asp Leu Ser Asp Lys Gly Gln 
465                 470                 475                 480 


Ala Ser Gly Leu Leu Leu Pro Leu Asn Lys Leu Leu Ala Thr Ala Gln 
                485                 490                 495     


Glu Lys Gln Asp Glu Arg Leu Leu Ala Thr Leu Glu Gly Ala His Val 
            500                 505                 510         


Phe Gln Val Cys Thr Gln Ala Gln Val Gln Gln Leu Val Asn Ser Ile 
        515                 520                 525             


Cys Ala Ile Pro Thr Gly Asp Leu Pro Leu Pro Arg Phe Gly Arg Val 
    530                 535                 540                 


Ile Glu Arg Asn His Asn Ala Gly Leu Lys Thr Gly Leu Pro Ser Arg 
545                 550                 555                 560 


Val Asn Arg Gln Ala Met Glu Gln Asn Pro Ala Gln Lys Cys Gln Tyr 
                565                 570                 575     


Val Val Leu Lys Met Leu Tyr Glu Arg Pro Phe Arg Val Trp Leu Glu 
            580                 585                 590         


Gly Ala Thr Asp Ala Met Leu Ser Thr Trp Leu Thr Thr Ala Leu Asn 
        595                 600                 605             


Arg Ser Thr Thr Ala Ala Arg Asn Asn Pro Asp Val Ser Arg Lys Pro 
    610                 615                 620                 


Gln Asp Glu Arg Glu Leu Val Thr Ser Arg Ala Ala Lys Leu Pro Ile 
625                 630                 635                 640 


Ala Ile Gly Gly Lys Asp Gly Gln Gly Lys Asn Lys Ser Ile Arg Gln 
                645                 650                 655     


Phe Phe His Asp Leu Ser Ala Ala Thr Ala Ser Glu Met Arg Val Gln 
            660                 665                 670         


Arg Gly Tyr Ala Ser Asp Ala Glu Lys Ala Arg Glu Gln Ala Glu Tyr 
        675                 680                 685             


Ile Asp Glu Leu Leu Arg Asp Val Val Ala Leu Ala Phe Lys Asp Phe 
    690                 695                 700                 


Leu Asp Gly Lys Gly Leu Cys Trp Leu Leu Asp Ile Asp Pro Lys Gln 
705                 710                 715                 720 


Ala Leu Gln Pro Ile Arg Cys Cys Pro Thr Glu Asn Ile Gln Leu Pro 
                725                 730                 735     


Ala Ser Thr Leu Gln Ile Val Asn Trp Gln Pro Val Leu Tyr Phe Leu 
            740                 745                 750         


Leu His Leu Met Pro Val Gly Glu Val Ser Gln Leu Leu His Gln Leu 
        755                 760                 765             


Ala Lys Trp Glu Ile Leu Ala Lys Pro Glu Gln Ala Arg Asn Asp Thr 
    770                 775                 780                 


Glu Gly Ile Arg Ile Lys Ala Leu Gln His Thr Leu Lys Leu Tyr Leu 
785                 790                 795                 800 


Asp Met His Asp Ser Gln Tyr Thr Gly Asp Asp Ala Met Pro Thr Val 
                805                 810                 815     


Glu Arg Asp Val Leu Thr Thr Phe Ser Ser Phe Tyr Glu Asn Pro Arg 
            820                 825                 830         


Val Phe Ala Gln Val Phe Glu Asn Gln Gly Asn Gly Arg Glu Arg Ala 
        835                 840                 845             


Gln Tyr Leu Pro Gln Arg Gly Leu Arg Glu Ile Arg Arg Phe Gly His 
    850                 855                 860                 


Thr Pro Val Leu Gln Thr Leu Val Lys Lys Lys Ile Thr Ala Glu Asp 
865                 870                 875                 880 


Val Ser Arg Cys Leu Thr Ala Glu Ala Pro Leu Lys Asn Gly Ile Tyr 
                885                 890                 895     


Ser Val Val Ala Glu Ala Gln Ser Gln Arg Glu Ala Leu His Ala Gln 
            900                 905                 910         


Trp Val Lys Glu Arg Lys Gln Phe Glu Trp Tyr Gln Asp Tyr Ala Ala 
        915                 920                 925             


Ala Leu Lys Lys Val Val Ala His Arg Gln Asp Ser Asn His Ile Arg 
    930                 935                 940                 


Leu Val Asp His Val Ala Ala His Arg Ile Val Met Lys Val Leu Ala 
945                 950                 955                 960 


Arg Leu Ala Asp Phe Ser Gly Leu Phe Glu Arg Asp Leu Thr Phe Val 
                965                 970                 975     


Thr Leu Ala Thr Leu His Glu His Gln Leu Lys Pro Glu Asp Phe Phe 
            980                 985                 990         


Val Thr Asp Asn Pro Pro Lys Tyr  Asn Lys Lys Gly Lys  Met Glu Asp 
        995                 1000                 1005             


Asp Gly  Leu Thr Leu Phe Lys  Lys Gly Gln Ile Ile  Glu Ala Met 
    1010                 1015                 1020             


Gly Lys  Val Gln Val Ser Arg  Asn Ala Val Lys Gln  Ala Ile Val 
    1025                 1030                 1035             


Gly Arg  Val Asn Leu Asp Leu  Tyr Arg Ser Ile Arg  Asn Asp Phe 
    1040                 1045                 1050             


Ala His  Phe Asn Met Leu Tyr  Gly Lys Gln Arg Thr  Thr Glu Ser 
    1055                 1060                 1065             


Pro Ser  Asn Lys Met Leu Arg  Cys Ser Val Ala Met  Gly Leu Asn 
    1070                 1075                 1080             


Val Thr  Cys Trp Val Asn Cys  Ala Arg Asp Leu Met  Ser Tyr Asp 
    1085                 1090                 1095             


Arg Lys  Leu Lys Asn Ala Val  Ser Gln Ser Ile Met  Glu Leu Leu 
    1100                 1105                 1110             


Glu Arg  Glu Gly Phe Ile Leu  Thr Trp Glu Met Asn  Ser His His 
    1115                 1120                 1125             


Gln Leu  Cys Asn Ala Thr Leu  Glu Ser Arg Val Val  His His Leu 
    1130                 1135                 1140             


Gly Asp  Lys Lys Phe Pro Leu  Lys Glu Asp Lys Arg  Ala Phe Cys 
    1145                 1150                 1155             


Arg Ile  Thr Glu Ser Leu His  Ser Asp Ala Phe Val  Arg Met Leu 
    1160                 1165                 1170             


Ala Val  Ala Phe Gly Gly Ala  Ala His Pro Asn Gln  Asp Ile Gly 
    1175                 1180                 1185             


Thr Leu  Asp Leu Gln Thr Val  Asn Trp Glu Gly Ala  Lys Ala Lys 
    1190                 1195                 1200             


Trp Ala  Gly Ser Gln 
    1205             


<210>  343
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  343

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Leu Tyr Gln Ile Val  Ser Ala Phe Asn Phe  Gly Ser Lys 
    1205                 1210                 1215             


Leu Leu  Tyr Ile Ser Glu Asp  Gly Arg Trp Lys Met  Ala Gly Gly 
    1220                 1225                 1230             


Ala Phe  Pro Gly Lys Tyr Gly  Arg Phe Glu Asn Asp  Tyr Asn His 
    1235                 1240                 1245             


Arg Thr  Ser Leu Ser Lys Val  Ile Arg Leu Phe Glu  Asn Glu Ser 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ile Ile Tyr  Trp Arg Asp Tyr Val  Asp His Met 
    1265                 1270                 1275             


Lys Tyr  Tyr Val Asn Gln Asn  Gln Ser Ile Met Glu  Ile Tyr Ser 
    1280                 1285                 1290             


Ala Phe  Tyr Ser Lys Val Leu  Gly Tyr Ser Ala Lys  Leu Arg Lys 
    1295                 1300                 1305             


Ser Val  Val Phe Asn Leu Gln  Ala Ala Leu Glu Lys  His His Ile 
    1310                 1315                 1320             


Asn Pro  Glu Cys Ile Trp Met  Thr Ser Asp Gly Lys  Cys Ala Asp 
    1325                 1330                 1335             


Ile Lys  Leu Met Lys Asn Leu  Glu Ser Gln Lys Phe  Thr Tyr Lys 
    1340                 1345                 1350             


Leu Ala  Lys Arg Glu Gly Glu  Lys Thr Glu Arg Lys  Ile Cys Met 
    1355                 1360                 1365             


Asn Ala  Leu Asn Glu Asn Phe  Leu Lys Thr Ile Arg  Thr Ser Leu 
    1370                 1375                 1380             


Glu Tyr  Lys Lys 
    1385         


<210>  344
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  344

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Thr Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Asp Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val His Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1400                 1405                 1410         


<210>  345
<211>  1432
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  345

Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser Val Gly 
1               5                   10                  15      


Glu Asn Lys Asn Glu Ala Gln Leu Ser Arg Gln Ser Leu Leu Tyr Tyr 
            20                  25                  30          


Ala Pro Val Lys Asp Gly Lys Val Arg Met Glu Ser Lys Asp Leu Glu 
        35                  40                  45              


Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr Asn Val 
    50                  55                  60                  


Ile Thr Pro Glu Ile Asp Leu Cys Lys Glu Glu Asn Arg Glu Trp Ile 
65                  70                  75                  80  


Val Glu Asp Leu Thr Lys Asn Phe Asn Ala Val Ile Asn Asn Ala Leu 
                85                  90                  95      


Arg Ser Ile Lys Asn Pro Lys Glu Lys Arg Glu Glu Arg Val Glu Lys 
            100                 105                 110         


Glu Val Ala Phe Ile Leu Asn Leu Asn Lys Asn Ser Ile Lys Ile Lys 
        115                 120                 125             


Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe Ser Ala 
    130                 135                 140                 


Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser Lys Glu 
145                 150                 155                 160 


Glu Ala Tyr Ile Arg Glu Met Ile Ser Asn Leu Val Leu Arg Lys Leu 
                165                 170                 175     


Lys Lys Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Cys Lys Met 
            180                 185                 190         


Gln Met Thr Glu Ile Thr Ile Ser Leu Met Ser Ala Ile Cys Leu Tyr 
        195                 200                 205             


Gly Asn Val Glu Ser Phe Asp Pro Val Ile Leu Lys Ala Phe Phe Glu 
    210                 215                 220                 


Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile Val 
225                 230                 235                 240 


Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Ala Glu Lys Asp 
                245                 250                 255     


Gly Lys His Leu Leu Ile Pro Ala Asn Ala Asp His Arg Lys Lys Lys 
            260                 265                 270         


Tyr Val Phe Glu Phe Met Arg Lys Tyr Ala Ala Ala Gly Glu Lys Glu 
        275                 280                 285             


Lys Arg Glu Ile Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr Leu 
    290                 295                 300                 


Cys Gly Lys Ser Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp Met 
305                 310                 315                 320 


Thr Glu Ser His Asn Cys Ile Ser Gly Glu Ile Glu Glu Ile Phe Asn 
                325                 330                 335     


Glu Ile Glu Lys Leu Glu Asn Ser Tyr Lys Gln Lys Arg Glu Glu Lys 
            340                 345                 350         


Lys Lys Thr Arg Glu Glu Leu Asp Lys Ile Gln Glu Val Arg Lys Gly 
        355                 360                 365             


Asn Lys Arg Asn Thr Asn Ser Asn Asn Gln Asn Tyr Lys Asn Asn Lys 
    370                 375                 380                 


Thr Asp Ser Asp Lys Lys Glu Asn Gln Ala Asp Ala Asn Glu Asn Lys 
385                 390                 395                 400 


Leu Lys Glu Asn Glu Leu Arg Asp Lys Ile Arg Arg Leu Ser Lys Glu 
                405                 410                 415     


Leu Glu Asn Leu Asp Ser Glu Val Arg Ile Lys Lys Glu Lys Leu Lys 
            420                 425                 430         


Asn Thr Thr Val Lys Glu Met Ala Leu Lys Tyr Arg Ala Ala Val Asn 
        435                 440                 445             


Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile Lys Glu 
    450                 455                 460                 


Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr Ile Asp 
465                 470                 475                 480 


Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp Arg Tyr 
                485                 490                 495     


Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu Trp Thr 
            500                 505                 510         


Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val Tyr His 
        515                 520                 525             


Phe Ala Ile Pro Asp Leu Ser Gly Ala Leu Glu Gly Glu Ser Val Ser 
    530                 535                 540                 


Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly Phe Asp 
545                 550                 555                 560 


Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met Glu Lys 
                565                 570                 575     


Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr Pro Glu 
            580                 585                 590         


Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met Lys Thr 
        595                 600                 605             


Leu Ser Glu Ile Glu Glu Ser Gln Thr Glu Glu Glu Arg Gln Lys Lys 
    610                 615                 620                 


His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp Ala Asp 
625                 630                 635                 640 


Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg Lys Lys 
                645                 650                 655     


Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr Lys Glu 
            660                 665                 670         


Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His Tyr Thr 
        675                 680                 685             


Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Glu Leu Thr Glu Tyr 
    690                 695                 700                 


Phe Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg Glu Lys 
705                 710                 715                 720 


Tyr Tyr Thr Asn Asn Val Trp Lys Tyr Tyr Asp Ile Glu Val Ile Asn 
                725                 730                 735     


Asn Ile Met Gly Lys Ile Tyr Cys Gly Arg Lys Tyr Arg Ala Ala Gln 
            740                 745                 750         


Val Pro Ala Phe Asn Asn Ile Ile Ser Arg Pro Ala Leu Pro Gln Leu 
        755                 760                 765             


Met Asp Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met Asn Cys 
    770                 775                 780                 


Pro Asp Arg Asp Val Ile Lys Lys Tyr Trp Ser Ser Leu Phe Phe Val 
785                 790                 795                 800 


Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Glu Lys Pro 
                805                 810                 815     


Glu Asp Asn Ile Lys Glu Arg Phe Phe Arg Ala Met Glu Lys Glu Ser 
            820                 825                 830         


Gly Gln Ala Lys Asp Gly Lys Glu Gln Lys Ala Trp Glu Ser Phe Glu 
        835                 840                 845             


Asn Arg Ile Asp Gln Ile Gly Arg Glu Arg Ser Phe Gly Ala Ile Cys 
    850                 855                 860                 


Gln Gly Leu Met Val Glu Tyr Met Leu Gln Asn Arg Asp Ile Ser Met 
865                 870                 875                 880 


Val Gln Ile Glu Thr Gly Asp Gly Lys Thr Asn Lys Lys Gln Ile Tyr 
                885                 890                 895     


Lys His Tyr Arg Thr Leu Leu Tyr Ile Cys Ile Arg Ser Ala Phe Thr 
            900                 905                 910         


Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro Val Leu Thr 
        915                 920                 925             


Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Thr Asp Gly Leu Lys 
    930                 935                 940                 


His Leu Ser Leu Phe Asp His Leu Lys Glu Thr Phe Asn Asp Ala Glu 
945                 950                 955                 960 


Ser Gly Ser Phe Trp Tyr Met Ala Ala His Phe Ile Asn Gln Lys Tyr 
                965                 970                 975     


Leu Asn His Leu Ile Gly Ser Ile Arg Asn Tyr Leu Gln Phe Thr Glu 
            980                 985                 990         


Asp Ile Glu Asp Arg Ala Leu Ser  Leu Gly Asp Cys Ala  Asp Asn Lys 
        995                 1000                 1005             


Arg Glu  Glu Lys Asn Leu Arg  Tyr Arg Asn Thr Leu  Glu Ile Leu 
    1010                 1015                 1020             


Glu Phe  Val Ala Gln Phe Cys  Glu Arg Thr Thr Asn  Val Met Glu 
    1025                 1030                 1035             


Asp Tyr  Phe Glu Ser Asn Gln  Glu Tyr Ala Ala Tyr  Leu Ser Gly 
    1040                 1045                 1050             


Phe Val  Asp Tyr Asn Val Ser  Lys Lys Glu Thr Asp  Ile Glu Lys 
    1055                 1060                 1065             


Ala Leu  Tyr Gly Phe Cys Arg  Gln Lys Phe Lys Val  Asp Gly Lys 
    1070                 1075                 1080             


Glu Tyr  Met Ala Gly Ile Tyr  Tyr Asp Gly Glu Asn  Leu Ile Pro 
    1085                 1090                 1095             


Asn Arg  Asn Ile Ile Arg Ala  Asn Met Tyr Gly Asn  Val Ser Cys 
    1100                 1105                 1110             


Leu Lys  Pro Tyr Met Asp Arg  Ile Thr Leu Lys Glu  Ile Arg Thr 
    1115                 1120                 1125             


Met Tyr  Ala Asp Gln Asn Lys  Leu Asp Thr Val Leu  Arg Glu Gly 
    1130                 1135                 1140             


Val Cys  Arg Thr Glu Glu Glu  Gln Lys Ala Tyr Arg  Glu Tyr Gln 
    1145                 1150                 1155             


Asn Glu  Lys Asn Arg Ile Glu  Leu Phe Asp Leu Cys  Thr Tyr Thr 
    1160                 1165                 1170             


Gln Ile  Leu Asn Asp Met Gln  Ala Arg Leu Ile Gly  Trp Ser Tyr 
    1175                 1180                 1185             


Met Arg  Glu Arg Asp Leu Met  Tyr Tyr Gln Leu Gly  Tyr Tyr Tyr 
    1190                 1195                 1200             


Thr Lys  Leu Phe Trp Thr Asp  Ala Ile Ser Glu Glu  Asp Ala Arg 
    1205                 1210                 1215             


Arg Arg  Leu Val Gly Glu Leu  Val Asn Val Glu Asp  Gly Val Ile 
    1220                 1225                 1230             


Leu Tyr  Gln Ile Leu Ala Phe  Asn Ser Tyr Asn Leu  Pro Ile Ile 
    1235                 1240                 1245             


Ala Asn  Lys Asn Asn Thr Val  Thr Phe Leu Lys Gly  Glu Gly Ser 
    1250                 1255                 1260             


Ile Gly  Gly Lys Ala Ile Thr  Ala Phe Leu Lys Asn  Tyr Glu Asn 
    1265                 1270                 1275             


Ala Glu  Arg Ile Tyr Glu Glu  Ala Leu Asp Leu Phe  Glu Asn Thr 
    1280                 1285                 1290             


Asp Glu  His Ala Ala Ile Ile  Asn Thr Arg Asn Tyr  Ile Glu His 
    1295                 1300                 1305             


Phe Lys  Tyr Phe Ile Lys Ser  Asp Arg Ser Met Met  Asp Leu Tyr 
    1310                 1315                 1320             


Ser Glu  Val Tyr Asp Arg Phe  Phe Arg His Asp His  Asn Arg Lys 
    1325                 1330                 1335             


Lys Asn  Val Pro Asp Ser Leu  Lys Asn Val Leu Ala  Asp Asn Phe 
    1340                 1345                 1350             


Met Ile  Ala Asp Ile Ser Met  Glu Leu Gly Ser Lys  Lys Val Gly 
    1355                 1360                 1365             


Glu Lys  Lys Lys Gly Phe Arg  Glu His Lys Ser Ala  Arg Ile Glu 
    1370                 1375                 1380             


Phe Thr  Asp Lys Gly Ile Arg  Ser Thr Asp Met Thr  Tyr Thr Val 
    1385                 1390                 1395             


Lys Pro  Asp Pro Lys Asp Ser  Lys Lys Asp Glu Lys  Val Leu Val 
    1400                 1405                 1410             


Pro Ala  Arg Ser Glu Val Phe  Leu Lys Gln Phe Gln  Lys Ile Leu 
    1415                 1420                 1425             


Glu Tyr  Arg Ile 
    1430         


<210>  346
<211>  1215
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  346

Val His Gly Asn Ala Glu Ser Phe Asp Pro Val Ile Leu Lys Ala Phe 
1               5                   10                  15      


Phe Lys Glu Ile Asp Lys Asp Tyr Met Lys Asn Glu Gln Met Glu Glu 
            20                  25                  30          


Ile Val Arg Ser Ile Glu Ser Gln Ser Val Lys Ala Lys Val Ala Glu 
        35                  40                  45              


Lys Asp Gly Lys Tyr Leu Leu Leu Pro Ala Asn Ala Asp His Arg Lys 
    50                  55                  60                  


Lys Lys Tyr Ala Phe Glu Phe Met Arg Lys Tyr Ala Ala Ala Glu Ala 
65                  70                  75                  80  


Glu Gly Lys Gln Glu Leu Thr Glu His Ile Gln Ala Leu Ile Gly Leu 
                85                  90                  95      


Tyr Leu Cys Gly Glu Ser Glu Tyr Gln Asp Ala Lys Asn Cys Phe Tyr 
            100                 105                 110         


Asp Met Val Glu Asn His Glu Cys Met Ser Gly Glu Ile Glu Glu Ile 
        115                 120                 125             


Tyr Asn Thr Ile Lys Glu Leu Lys Asn Leu Ser Arg Gln Lys Arg Glu 
    130                 135                 140                 


Glu Arg Lys Glu Ile Lys Glu Lys Ile Arg Glu Ile Glu Lys Ser Gly 
145                 150                 155                 160 


Lys Gly Asp Lys Arg Thr Pro Asn Asn Asn Ser Asn Lys Ser Cys Lys 
                165                 170                 175     


Asn Asp Lys Lys Asp Asn Asp Asn Lys Glu Asn Asp Ile Asn Leu Asn 
            180                 185                 190         


Glu Asn Asp Leu Lys Lys Ala Ile Glu Glu Ile Asp Lys Glu Leu Ala 
        195                 200                 205             


Lys Ile Pro Leu Glu Ile Cys Ile Asn Asn Glu Lys Leu Asn Asn Ala 
    210                 215                 220                 


Val Ile Lys Thr Met Ser Val Lys Tyr Arg Ala Ala Val Lys Tyr Leu 
225                 230                 235                 240 


Val Ser Lys Gly Lys Lys Thr Val Leu Gly Glu Ile Lys Glu Lys Lys 
                245                 250                 255     


Asp Cys Ser Cys Ala Asp Leu Tyr Trp Ile Asp Tyr Ile Asp Asn Thr 
            260                 265                 270         


Val Lys Lys Leu Leu Leu Asp Ser Arg Asn Lys Gly Met Tyr Arg Tyr 
        275                 280                 285             


Glu Ile Ser Phe Leu Ser Asn His Ile Trp Lys Glu Trp Thr Gln Tyr 
    290                 295                 300                 


Ile Ser Gly Lys Tyr Ile Glu Leu Gly Lys Gly Val Tyr His Phe Ala 
305                 310                 315                 320 


Ile Pro Asp Leu Ser Gly Ala Leu Glu Gly Lys Pro Val Ser Val Cys 
                325                 330                 335     


Glu Val Lys Pro Glu Tyr Arg Lys Gly Ile Ser Gly Phe Asp Tyr Glu 
            340                 345                 350         


Arg Ile Lys Ala Glu Glu Ser Leu Asp Arg Glu Met Glu Glu Tyr Val 
        355                 360                 365             


Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Ala Ala Pro Glu Asn Glu 
    370                 375                 380                 


Arg Glu Lys Pro Gly His Glu Asp Val Leu Ile Met Lys Thr Ser Asp 
385                 390                 395                 400 


Glu Leu Ile Ala Glu Asn Lys Lys Asn Gln Glu Pro Ile Val Leu Tyr 
                405                 410                 415     


Lys Asp Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg 
            420                 425                 430         


Phe Arg Glu Lys Glu Asp Ser Phe Ile Asn Leu Tyr Ser Gly Glu Asp 
        435                 440                 445             


Leu Tyr Lys Glu Ile Arg Asn Glu Leu Tyr Thr Val Arg Asn Ile Thr 
    450                 455                 460                 


Phe His Tyr Thr Thr Lys Ala Glu Lys Gly Gln Ile Gln Lys His Glu 
465                 470                 475                 480 


Met Ala Glu Tyr Phe Phe Glu Glu Glu Leu Ala Asp Ile Ser Gly Val 
                485                 490                 495     


Phe Arg Lys Lys Tyr Tyr Ser Asn Asn Val Trp Lys Phe Tyr Asp Met 
            500                 505                 510         


Glu Val Ile Asn Asp Leu Met Asp Lys Ile Tyr Ser Gly Arg Lys Tyr 
        515                 520                 525             


Arg Ala Ala Gln Ile Pro Ala Phe Asn Asn Ile Ile Ser Arg Pro Ala 
    530                 535                 540                 


Leu Pro Gln Ile Ile Asn Gly Phe Val Lys Gly Asn Ser Leu Lys Lys 
545                 550                 555                 560 


Ile Met Asn Tyr Pro Asp Arg Glu Ile Ile Lys Gln Tyr Trp Ser Ala 
                565                 570                 575     


Leu Phe Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu 
            580                 585                 590         


Gln Glu Asn Pro Glu Glu Asn Ile Arg Glu Arg Phe Leu Arg Val Leu 
        595                 600                 605             


Ala Arg Lys Leu Glu Glu Thr Ser Asp Ala Lys Glu Gln Lys Ala Trp 
    610                 615                 620                 


Glu Ser Phe Asp Lys Arg Ile Ser Glu Ile Gly Arg Lys Arg Ser Phe 
625                 630                 635                 640 


Gly Glu Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Asn 
                645                 650                 655     


Asp Ser Pro Met Val Arg Lys Glu Asn Ile His Lys Arg Thr Gln Ser 
            660                 665                 670         


Arg Asp Thr Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Ile Cys 
        675                 680                 685             


Ile Arg Asp Ala Phe Ile Glu Tyr Leu Lys Glu Lys Trp Gln Gly Leu 
    690                 695                 700                 


Arg Glu Pro Val Leu Ile Lys Lys Glu Trp Ser Glu Glu Glu Phe Cys 
705                 710                 715                 720 


His Pro Asp Asn Val Glu His Leu Ser Leu Tyr Asp His Leu Lys Asp 
                725                 730                 735     


Leu Phe His Ser Thr Ala Ser Gly Pro Ser Trp Tyr Ile Ala Ala His 
            740                 745                 750         


Phe Ile Asn Pro Lys Tyr Leu Asn His Leu Ile Gly Ser Ile Arg Asn 
        755                 760                 765             


Tyr Leu Gln Phe Thr Glu Asp Ile Glu Arg Arg Ala Val Ser Leu Gly 
    770                 775                 780                 


Lys Cys Val Asp Asn Glu Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn 
785                 790                 795                 800 


Thr Leu Glu Ile Leu Glu Phe Val Leu Gln Phe Cys Gly Lys Thr Thr 
                805                 810                 815     


Lys Val Met Glu Asp Tyr Phe Glu Ser Asn Glu Val Tyr Ala Ala Tyr 
            820                 825                 830         


Leu Ser Asp Phe Val Asp Tyr Lys Thr Pro Lys Asn Ile Thr Asp Ile 
        835                 840                 845             


Glu Thr Ala Leu His Ile Phe Cys Glu Gln Lys Val Asn Val Asp Arg 
    850                 855                 860                 


Lys Glu Ser Met Val Gly Ile Tyr Tyr Asp Gly Gly Asn Leu Ile Pro 
865                 870                 875                 880 


Asn Arg Asn Ile Ile Arg Ala Asn Met Tyr Gly Asn Val Ser Cys Leu 
                885                 890                 895     


Lys Ala Ser Met Asp Lys Ile Lys Tyr Ala Glu Ile Arg Lys Met Tyr 
            900                 905                 910         


Ile Asp Lys Ser Lys Leu Asp Ser Val Leu Lys Glu Gly Val Cys Arg 
        915                 920                 925             


Thr Lys Glu Asp Gln Lys Ala Leu Lys Glu Phe Gln Asn Glu Lys Asn 
    930                 935                 940                 


Arg Ile Glu Leu Leu Asp Leu Ser Thr Tyr Thr Glu Ile Leu Asn Asp 
945                 950                 955                 960 


Met Gln Ala Ile Leu Ile Gly Trp Thr Tyr Met Arg Glu Arg Asp Leu 
                965                 970                 975     


Met Tyr Tyr Gln Leu Gly Tyr Tyr Tyr Thr Lys Leu Phe Trp Thr Asp 
            980                 985                 990         


Ser Ile Ser Glu Glu Asp Glu Arg  Arg Lys Leu Thr Gly  Asp Glu Val 
        995                 1000                 1005             


Asn Ile  Glu Asp Gly Ala Ile  Leu Tyr Gln Ile Leu  Ala Phe Asn 
    1010                 1015                 1020             


Thr Tyr  His Leu Pro Val Ile  Ser Asn Lys Lys Asn  Thr Val Ser 
    1025                 1030                 1035             


Phe Val  Lys Asp Asn Gly Ser  Ile Gly Gly Lys Ala  Leu Arg Ala 
    1040                 1045                 1050             


Phe Phe  Arg Asn Phe Glu Asn  Ala Ile Pro Ile Tyr  Leu Glu Gly 
    1055                 1060                 1065             


Leu Asn  Leu Phe Glu Asn Thr  Asp Glu His Asp Asp  Ile Ile Asp 
    1070                 1075                 1080             


Thr Arg  Asn Tyr Ile Glu His  Phe Lys Tyr Phe Ile  Lys Ser Asp 
    1085                 1090                 1095             


Arg Ser  Met Met Asp Leu Tyr  Ser Glu Val Tyr Asp  Arg Phe Phe 
    1100                 1105                 1110             


Arg His  Asp His Lys Leu Lys  Lys Ser Val Pro Glu  Val Leu Thr 
    1115                 1120                 1125             


Asn Ile  Leu Ala Arg Asn Phe  Met Asp Ala Arg Ile  Tyr Met Lys 
    1130                 1135                 1140             


Leu Gly  Ser Lys Gln Val Val  Lys Glu Lys Thr Gly  Val Ser Arg 
    1145                 1150                 1155             


Glu His  Lys Ala Ser Lys Ile  Val Phe Thr Asp Lys  Gly Ile Glu 
    1160                 1165                 1170             


Ser Thr  Ala Leu Thr Tyr Thr  Ile Lys Pro Asp Ser  Lys Asp Asn 
    1175                 1180                 1185             


Lys Lys  Glu Ala Lys Ile Leu  Val Asp Ala Arg Ser  Glu Val Phe 
    1190                 1195                 1200             


Leu Lys  Gln Phe Gln Lys Ile  Leu Glu Tyr Arg Ala  
    1205                 1210                 1215 


<210>  347
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  347

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Asn Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys His Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Asn Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Glu 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Val Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Thr Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Lys Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Glu  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  348
<211>  1001
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  348

Met Ile Cys Lys Lys Lys Leu Asn Gln Ile Gln Ser Ile Lys Asn Ser 
1               5                   10                  15      


Leu Glu Lys Asn Lys Ala His Phe Lys Lys Glu Ser Ile Asn Asn Thr 
            20                  25                  30          


Thr Asp Arg Val Lys Gly Asn Asn Lys Lys Ser Leu Phe Tyr Glu Tyr 
        35                  40                  45              


Tyr Arg Asn Ser Ser Lys His Gln Glu Tyr Val Asn Asn Ile Phe Glu 
    50                  55                  60                  


Ala Phe Asp Lys Leu Tyr Ser Asn Ser His Glu Asp Ile Asn Asn Leu 
65                  70                  75                  80  


Phe Leu Glu Ile Thr Lys Asp Ser Asn Asn Arg Asn Ile Arg Lys Ile 
                85                  90                  95      


Arg Glu Val Tyr His Glu Ile Leu Asn Lys Asn Lys Thr Glu Phe Gly 
            100                 105                 110         


Glu Glu Leu Tyr Lys Lys Ile Gln Asp Asn Ile Ser Asn Phe Asp Lys 
        115                 120                 125             


Leu Leu Glu Ile Glu Pro Glu Ile Lys Glu Leu Thr Lys Ser Gln Ile 
    130                 135                 140                 


Phe Tyr Lys Tyr Tyr Ile Asp Lys Val Ser Leu Asp Gly Thr Asn Ile 
145                 150                 155                 160 


Lys His Cys Phe Phe His Leu Val Glu Ile Glu Val Asn Gln Leu Leu 
                165                 170                 175     


Lys Asn Tyr Val Tyr Ser Lys Arg Ser Thr Asn Lys Glu Lys Leu Glu 
            180                 185                 190         


Asn Ile Phe Glu Tyr Cys Lys Leu Arg Asn Leu Val Lys Asn Lys Leu 
        195                 200                 205             


Val Asn Lys Leu Asn Ser Tyr Ile Arg Asn Cys Gly Lys Tyr Asn Ser 
    210                 215                 220                 


Tyr Ile Asn Asn Asn Asp Val Val Asn Ser Glu Lys Ile Ser Glu Ile 
225                 230                 235                 240 


Arg Thr Lys Glu Ala Phe Leu Arg Ser Ile Ile Gly Val Ser Ser Ser 
                245                 250                 255     


Ala Tyr Phe Ser Leu Arg Asn Ile Leu Asn Thr Asp Asn Thr Gln Asp 
            260                 265                 270         


Ile Thr Asn Lys Val Lys Gly Glu Val Glu Lys Leu Tyr Gln Glu Asn 
        275                 280                 285             


Lys Lys Val Lys Leu Glu Glu Arg Leu Lys Leu Phe Phe Gly Asn Asn 
    290                 295                 300                 


Phe Asp Ile Asn Asn Gln Gln Glu Ile Glu Asp Phe Leu Met Asn Ile 
305                 310                 315                 320 


Asp Lys Ile Ile Ser Asn Ile Arg His Glu Ile Ile His Phe Lys Ile 
                325                 330                 335     


Glu Ala Asn Ala His Ser Ile Phe Asp Phe Asn Asn Val Thr Leu Gly 
            340                 345                 350         


Asn Lys Ala Lys Asn Ile Phe Asn Asn Glu Ile Asn Glu Glu Arg Ile 
        355                 360                 365             


Lys Phe Lys Ile Phe Lys Gln Leu Asn Ser Ala Asn Val Phe Asp Tyr 
    370                 375                 380                 


Leu Ser Asp Glu Asn Ile Thr Glu Tyr Met Gly Lys Val Ile Phe Ser 
385                 390                 395                 400 


Phe Thr Asn Arg Asn Ile Pro Phe Val Pro Ser Phe Arg Lys Ile Tyr 
                405                 410                 415     


Asn Arg Val Gln Asp Leu Ala Asn Ser Leu Lys Ile Lys Glu Trp Lys 
            420                 425                 430         


Ile Ser Asp Glu Ser Glu Gly Lys Asp Ala Gln Ile Tyr Leu Leu Lys 
        435                 440                 445             


Asn Ile Tyr Tyr Gly Glu Phe Leu Asp Asp Phe Leu Asn Glu Lys Asn 
    450                 455                 460                 


Glu Lys Phe Ile Lys Ile Lys Asp Glu Ile Ile Glu Leu Asn Lys Asn 
465                 470                 475                 480 


Gln Asn Lys Ile Thr Gly Phe Tyr Lys Leu Glu Lys Phe Glu Lys Ile 
                485                 490                 495     


Glu Glu Lys Asn Pro Lys Lys Tyr Leu Glu Ile Ile Gln Ser Leu Tyr 
            500                 505                 510         


Met Ile Asn Ile Glu Glu Ile Asp Asn Glu Glu Lys Asn Ile Phe Leu 
        515                 520                 525             


Asp Phe Ile Gln Lys Ile Phe Leu Lys Gly Phe Phe Glu Phe Ile Lys 
    530                 535                 540                 


Asn Asn Tyr Asn Tyr Leu Leu Glu Leu Lys Lys Val Gln Asp Lys Lys 
545                 550                 555                 560 


Asn Ile Phe Asp Arg Glu Met Ser Glu Tyr Ile Ala Gly Glu Lys Thr 
                565                 570                 575     


Leu Glu Asp Met Glu Glu Ile Asn Lys Ile Ile Gln Asp Ile Lys Ile 
            580                 585                 590         


Thr Glu Ile Asp Lys Ile Leu Asn Gln Thr Asp Lys Ile Asn Cys Phe 
        595                 600                 605             


Tyr Leu Leu Leu Lys Leu Leu Asn Tyr Lys Glu Ile Thr Glu Leu Lys 
    610                 615                 620                 


Gly Asn Leu Glu Lys Tyr Gln Ile Leu Ser Lys Thr Asp Ile Tyr Glu 
625                 630                 635                 640 


Lys Glu Leu Met Leu Leu Asn Ile Val Asn Leu Asp Asn Asn Lys Val 
                645                 650                 655     


Lys Ile Glu Asn Phe Lys Ile Ser Ala Glu Glu Ile Gly Lys Phe Ile 
            660                 665                 670         


Glu Lys Ile Ser Arg Asn Lys Lys Ile Lys Thr Phe Glu Glu Leu Arg 
        675                 680                 685             


Asn Phe Glu Lys Arg Glu Asn Thr Gly Glu Tyr Tyr Asn Val Tyr Ser 
    690                 695                 700                 


Asp Asp Lys Asn Ile Lys Asn Ile Arg Asn Leu Tyr Asn Ile Lys Lys 
705                 710                 715                 720 


Tyr Gly Met Leu Asp Leu Leu Glu Arg Ile Ser Glu Lys Ser Asn Tyr 
                725                 730                 735     


Cys Ile Lys Lys Glu Val Leu Lys Glu Tyr Asp Lys Leu Lys Lys Lys 
            740                 745                 750         


Leu Glu Asp Lys Lys Thr Asp Phe Tyr Lys Ile Gln Lys Asp Leu His 
        755                 760                 765             


Tyr Lys Tyr Gln Lys Glu Tyr Lys Asn Phe Ser Lys Lys Asn Asn Pro 
    770                 775                 780                 


Glu Asp Tyr Glu Lys Tyr Lys Glu Ser Ile Lys Asn Ile Glu Lys Tyr 
785                 790                 795                 800 


Val His Leu Lys Asn Lys Ile Glu Phe Asn Glu Leu Asn Leu Leu Gln 
                805                 810                 815     


Ser Leu Leu Leu Lys Ile Leu His Arg Leu Val Gly Phe Thr Ser Ile 
            820                 825                 830         


Trp Glu Arg Asp Leu Arg Phe Arg Leu Ile Gly Glu Phe Ser Asp Glu 
        835                 840                 845             


Leu Asp Val Glu Asp Ile Phe Asp His Arg Glu Arg Tyr Arg Gly Thr 
    850                 855                 860                 


Arg Gly Gln Ile Cys Lys Lys Tyr Asp Gln Phe Ile Ser Val His Ile 
865                 870                 875                 880 


Glu Tyr Gln Asn Asn Asn Lys Met Lys Asn Ile Lys Phe Asp Asp Asn 
                885                 890                 895     


Asn Pro Ile Arg Asn Tyr Ile Ala His Phe Asn Tyr Leu Pro Thr Pro 
            900                 905                 910         


Lys Tyr Ser Ile Leu Lys Met Leu Glu Lys Leu Arg Glu Leu Leu Asp 
        915                 920                 925             


Tyr Asp Arg Lys Leu Lys Asn Ala Val Met Lys Ser Ile Lys Gly Ile 
    930                 935                 940                 


Leu Glu Glu Tyr Gly Phe Glu Ala Glu Phe Ile Ile Asn Pro Asp Lys 
945                 950                 955                 960 


Glu Ile Ile Leu Asn Ser Val Lys Ser Ile Glu Ile Ile His Leu Gly 
                965                 970                 975     


Lys Asn Asp Leu Lys Ser His Arg Asn Ser Glu Asp Leu Cys Lys Leu 
            980                 985                 990         


Val Ile Ala Met Leu Glu Tyr Ser  Glu 
        995                 1000     


<210>  349
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  349

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Ile Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Phe Asp Phe Lys Leu  Leu Asn 
    1400                 1405                 1410         


<210>  350
<211>  1208
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  350

Met Gln Ile Ile Lys Pro Tyr Gly Arg Ser Phe Thr Glu Thr Asn Gln 
1               5                   10                  15      


Arg Val Leu Leu Asp Lys His Arg Asp Lys His Asp Ile Ser Pro Phe 
            20                  25                  30          


Ala Ala Ser His Glu Lys Leu Val Ile Ala Gln Trp Val Ser Val Ile 
        35                  40                  45              


Asp Lys Ile Val Arg Lys Pro Asn Pro Lys Ala Lys Ile Ser Leu Pro 
    50                  55                  60                  


Thr Pro Gln Gln Tyr Gln Leu Arg Glu Thr Leu Gly Asn Ala Ala Trp 
65                  70                  75                  80  


Leu Glu Leu Asn Lys Arg Leu Pro Cys Ser Asp His Ala Val Phe Trp 
                85                  90                  95      


Arg Ser Lys Ile His Pro Tyr Gly His Ala Thr Gln Glu Gln Glu Pro 
            100                 105                 110         


Ala Pro Leu Leu Gln Gly Arg Trp Tyr Gln Arg Phe Val Gly Asp Ile 
        115                 120                 125             


Glu Pro Thr Ala Ile Thr Glu Asn Val Ala Gln Ile Ile Ala Glu Arg 
    130                 135                 140                 


Ile Ala Ser His Leu Tyr Glu Ala Glu Leu Arg Leu Ser Pro Glu Ala 
145                 150                 155                 160 


Glu Pro Arg Gly Lys Gly Lys Ile Gln Ala Gln Ala Glu Ser Ile Glu 
                165                 170                 175     


Lys Asn Thr Leu His Gln Pro Lys Leu Ser Ala Thr Trp Cys Asp Ala 
            180                 185                 190         


Asp Trp Thr Ala Tyr Asn Arg His Asp Val Ala Glu Arg Ile Tyr Leu 
        195                 200                 205             


Glu Ala Lys Phe Arg Leu Glu Gln Lys Gln Glu Ala Arg Lys Asn Lys 
    210                 215                 220                 


Gln Pro Met Gln Leu Glu Trp Arg Ile Asp Arg Ser Leu Thr Gly Lys 
225                 230                 235                 240 


Ile Leu Phe Glu His Trp Ala Lys Val Tyr Ser Gly Thr Asp Gly Lys 
                245                 250                 255     


Ser Arg Ile Thr Glu Ala Lys Gln Glu Lys Pro Gly Leu Phe His Leu 
            260                 265                 270         


His Met Ala Val Lys Asp Phe Tyr Thr Arg Leu Phe Asp Arg Asp Arg 
        275                 280                 285             


Arg Asp Glu Thr Leu Val Glu Phe Leu Leu Pro Arg Lys Lys Lys Ala 
    290                 295                 300                 


Leu Arg Glu Lys Leu Glu Gln Lys Ser Lys Asn Thr Asp Leu Ala Ala 
305                 310                 315                 320 


Ser Ile Arg Leu Gly Lys Ile Leu Tyr Tyr Arg Glu Ala Glu Ser Glu 
                325                 330                 335     


Thr Val Pro Leu Ala Asn Ser Arg Phe Trp Gly Ser Glu Gly Gln Ala 
            340                 345                 350         


Glu Ile Lys Arg Ala Glu Ala Phe Val Arg Val Trp Arg His Val Leu 
        355                 360                 365             


Gly Gln Ser Asn Leu Thr Leu Ala Asn Trp Ala Ser Leu Ala Ser Pro 
    370                 375                 380                 


Asp Glu Leu Trp Glu Lys Asp Ser Phe Asp Ser Lys Phe Leu Asp His 
385                 390                 395                 400 


Val Glu Lys Leu Phe Ala Lys Asp Asn Gly Leu Asp Lys Arg Arg Gln 
                405                 410                 415     


Glu Phe Asp Gln Asn Leu Asn Leu Leu Leu Gly Asp Gly Ala Ser Ala 
            420                 425                 430         


Phe Met Ala Asp Asp Asp Ser Arg Gln Ala Ala Ile Arg Leu Ala Tyr 
        435                 440                 445             


Asp Val Gly Ser Ala Leu Arg His Ala Ala Phe His Phe Lys Gly Arg 
    450                 455                 460                 


Asp Lys Phe Leu Glu Val Leu Asp Lys Asp Leu Ser Asp Lys Gly Gln 
465                 470                 475                 480 


Ala Ser Gly Leu Leu Leu Pro Leu Asn Lys Leu Leu Ala Thr Ala Gln 
                485                 490                 495     


Glu Lys Gln Asp Glu Arg Leu Leu Ala Thr Leu Glu Gly Ala His Val 
            500                 505                 510         


Phe Gln Val Cys Thr Gln Ala Gln Val Gln Gln Leu Val Asn Ser Ile 
        515                 520                 525             


Cys Ala Ile Pro Thr Gly Asp Leu Pro Leu Pro Arg Phe Gly Arg Val 
    530                 535                 540                 


Ile Glu Arg Asn His Asn Ala Gly Leu Lys Thr Gly Leu Pro Ser Arg 
545                 550                 555                 560 


Val Asn Arg Gln Ala Met Glu Gln Asn Pro Ala Gln Lys Cys Gln Tyr 
                565                 570                 575     


Val Val Leu Lys Met Leu Tyr Glu Arg Pro Phe Arg Val Trp Leu Glu 
            580                 585                 590         


Gly Ala Thr Asp Ala Met Leu Ser Thr Trp Leu Thr Thr Ala Leu Asn 
        595                 600                 605             


Arg Ser Thr Thr Ala Ala Arg Asn Asn Pro Asp Val Ser Arg Lys Pro 
    610                 615                 620                 


Gln Asp Glu Arg Glu Leu Val Thr Ser Arg Ala Ala Lys Leu Pro Ile 
625                 630                 635                 640 


Ala Ile Gly Gly Lys Asp Gly Gln Gly Lys Asn Lys Ser Ile Arg Gln 
                645                 650                 655     


Phe Phe His Asp Leu Ser Ala Ala Thr Ala Ser Glu Met Arg Val Gln 
            660                 665                 670         


Arg Gly Tyr Ala Ser Asp Ala Glu Lys Ala Arg Glu Gln Ala Glu Tyr 
        675                 680                 685             


Ile Asp Glu Leu Leu Arg Asp Val Val Ala Leu Ala Phe Lys Asp Phe 
    690                 695                 700                 


Leu Asp Gly Lys Gly Leu Cys Trp Leu Leu Asp Ile Asp Pro Lys Gln 
705                 710                 715                 720 


Ala Leu Gln Pro Ile Arg Cys Cys Pro Thr Glu Asn Ile Gln Leu Pro 
                725                 730                 735     


Ala Ser Thr Leu Gln Ile Val Asn Trp Gln Pro Val Leu Tyr Phe Leu 
            740                 745                 750         


Leu His Leu Met Pro Val Gly Glu Val Ser Gln Leu Leu His Gln Leu 
        755                 760                 765             


Ala Lys Trp Glu Ile Leu Ala Lys Pro Glu Gln Ala Arg Asn Asp Thr 
    770                 775                 780                 


Glu Gly Ile Arg Ile Lys Ala Leu Gln His Thr Leu Lys Leu Tyr Leu 
785                 790                 795                 800 


Asp Met His Asp Ser Gln Tyr Thr Gly Asp Asp Ala Met Pro Thr Val 
                805                 810                 815     


Glu Arg Asp Val Leu Thr Thr Phe Ser Ser Phe Tyr Glu Asn Pro Arg 
            820                 825                 830         


Val Phe Ala Gln Val Phe Glu Asn Gln Gly Asn Gly Arg Glu Arg Ala 
        835                 840                 845             


Gln Tyr Leu Pro Gln Arg Gly Leu Arg Glu Ile Arg Arg Phe Gly His 
    850                 855                 860                 


Thr Pro Val Leu Gln Thr Leu Val Lys Lys Lys Ile Thr Ala Glu Asp 
865                 870                 875                 880 


Val Ser Arg Cys Leu Thr Ala Glu Ala Pro Leu Lys Asn Gly Ile Tyr 
                885                 890                 895     


Ser Val Val Ala Glu Ala Gln Ser Gln Arg Glu Ala Leu His Ala Gln 
            900                 905                 910         


Trp Val Lys Glu Arg Lys Gln Phe Glu Trp Tyr Gln Asp Tyr Ala Ala 
        915                 920                 925             


Ala Leu Lys Lys Val Val Ala His Arg Gln Asp Ser Asn His Ile Arg 
    930                 935                 940                 


Leu Val Asp His Val Ala Ala His Arg Ile Val Met Lys Val Leu Ala 
945                 950                 955                 960 


Arg Leu Ala Asp Phe Ser Gly Leu Phe Glu Arg Asp Leu Thr Phe Val 
                965                 970                 975     


Thr Leu Ala Thr Leu His Glu His Gln Leu Lys Pro Glu Asp Phe Phe 
            980                 985                 990         


Val Thr Asp Asn Pro Pro Lys Tyr  Asn Lys Lys Gly Lys  Met Glu Asp 
        995                 1000                 1005             


Asp Gly  Leu Thr Leu Phe Lys  Lys Gly Gln Ile Ile  Glu Ala Met 
    1010                 1015                 1020             


Gly Lys  Val Gln Val Ser Arg  Asn Ala Val Lys Gln  Ala Ile Val 
    1025                 1030                 1035             


Gly Arg  Val Asn Leu Asp Leu  Tyr Arg Ser Ile Arg  Asn Asp Phe 
    1040                 1045                 1050             


Ala His  Phe Asn Met Leu Tyr  Gly Lys Gln Arg Thr  Thr Glu Ser 
    1055                 1060                 1065             


Pro Ser  Asn Lys Met Leu Arg  Cys Ser Val Ala Met  Gly Leu Asn 
    1070                 1075                 1080             


Val Thr  Cys Trp Val Asn Cys  Ala Arg Asp Leu Met  Ser Tyr Asp 
    1085                 1090                 1095             


Arg Lys  Leu Lys Asn Ala Val  Ser Gln Ser Ile Met  Glu Leu Leu 
    1100                 1105                 1110             


Glu Arg  Glu Gly Phe Ile Leu  Thr Trp Glu Met Asn  Ser His His 
    1115                 1120                 1125             


Gln Leu  Cys Asn Ala Thr Leu  Glu Ser Arg Val Val  His His Leu 
    1130                 1135                 1140             


Gly Asp  Lys Lys Phe Pro Leu  Lys Glu Asp Lys Arg  Ala Phe Cys 
    1145                 1150                 1155             


Arg Ile  Thr Glu Ser Leu His  Ser Asp Ala Phe Val  Arg Met Leu 
    1160                 1165                 1170             


Ala Val  Ala Phe Gly Gly Ala  Ala His Pro Asn Gln  Asp Ile Gly 
    1175                 1180                 1185             


Thr Leu  Asp Leu Gln Thr Val  Asn Trp Glu Gly Ala  Lys Ala Lys 
    1190                 1195                 1200             


Trp Ala  Gly Ser Gln 
    1205             


<210>  351
<211>  1101
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  351

Met Arg Ile Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Ile Tyr Ser Glu 
            20                  25                  30          


Gln Ala Val Ser Asn Glu Thr Asn Asn Ile Leu Pro Val Lys Lys Met 
        35                  40                  45              


Asp Ser Phe Asn Leu Ser Ile Leu Asn Lys Thr Ile Ile Lys Phe Glu 
    50                  55                  60                  


Thr Val Lys Lys Gln Lys Leu Asn Leu Asp Gln Tyr Lys Ile Val Glu 
65                  70                  75                  80  


Lys Ile Phe Lys Tyr Pro Lys Gln Glu Leu Pro Lys Gln Ile Asn Ala 
                85                  90                  95      


Glu Glu Ile Leu Gln Phe Leu Asn His Lys Phe Gln Glu Pro Val Lys 
            100                 105                 110         


Tyr Trp Lys Asn Gly Lys Glu Glu Ser Phe Asn Leu Thr Leu Leu Ile 
        115                 120                 125             


Val Glu Ala Val Lys Thr Gln Glu Lys Arg Lys Leu Gln Pro Tyr Tyr 
    130                 135                 140                 


Asp Trp Lys Thr Trp Tyr Ile Gln Thr Lys Ser Asp Leu Leu Lys Lys 
145                 150                 155                 160 


Ser Ile Glu Asn Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg 
                165                 170                 175     


Lys Lys Ala Leu Leu Ala Trp Glu Thr Glu Phe Thr Thr Ser Gly Ser 
            180                 185                 190         


Ile Asp Leu Thr His Phe His Lys Val Tyr Met Thr Asp Val Leu Cys 
        195                 200                 205             


Thr Ala Leu Gln Lys Val Glu Pro Ser Ala Asp Glu Arg Gly Lys Met 
    210                 215                 220                 


Asn Ser Asn Ala Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Asn His 
225                 230                 235                 240 


Gln Pro Ala Ile Phe Gly Thr Arg Glu Ala Pro Asn Glu Val Asn Arg 
                245                 250                 255     


Ala Asp Asn Gln Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu 
            260                 265                 270         


Glu His Tyr Phe Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Ala Asp 
        275                 280                 285             


Asp Ile Ser His Tyr Leu Lys Ala Gln Thr Leu Lys Thr Thr Ile Glu 
    290                 295                 300                 


Lys Gln Leu Val Asn Ala Ile Arg Ala Asn Ile Ile Gln Gln Gly Lys 
305                 310                 315                 320 


Thr Asn His His Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile 
                325                 330                 335     


Arg Ile Lys Thr Asn Glu Ala Phe Val Leu Asn Leu Ile Gly Thr Cys 
            340                 345                 350         


Ala Phe Ala Ala Asn Asn Ile Arg Asn Met Val Asp Lys Glu Gln Ile 
        355                 360                 365             


Ser Asp Ile Leu Gly Lys Arg Glu Phe Ile Asp Ser Leu Thr Lys Ser 
    370                 375                 380                 


Arg Ile Ser Ser Gln Leu Tyr Ser Phe Phe Phe Gly Glu Asn Leu Ser 
385                 390                 395                 400 


Thr Asn Lys Ala Glu Lys Glu Thr Gln Leu Trp Gly Ile Arg Gly Ala 
                405                 410                 415     


Val Gln Gln Ile Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu 
            420                 425                 430         


Thr Thr Ile Phe Asn Ile Cys Lys Phe Glu Asn Pro Thr Asp Ala Asp 
        435                 440                 445             


Pro Lys Gln Gln Thr Asn Tyr Val Asp Ser Ile Tyr Lys Thr Leu Phe 
    450                 455                 460                 


Ile Lys Glu Leu Glu Lys Ile Pro Glu Ala Phe Ala Gln Gln Leu Lys 
465                 470                 475                 480 


Thr Gly Gly Ala Leu Ser Tyr Tyr Thr Val Glu Asn Leu Lys Thr Leu 
                485                 490                 495     


Leu Thr Thr Phe Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala 
            500                 505                 510         


Pro Gly Phe Lys Lys Val Leu Asn Gly Gly Ile Asn Tyr Gln Asn Ala 
        515                 520                 525             


Lys Gln Asp Glu Ser Phe Tyr Glu Leu Met Leu Glu Arg Tyr Leu Arg 
    530                 535                 540                 


Lys Glu Asn Phe Ala Glu Glu Ala Tyr Asn Ala Arg Tyr Phe Leu Leu 
545                 550                 555                 560 


Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Lys Phe Thr Ala Asp Arg 
                565                 570                 575     


Lys Ala Phe Ala Asp Ser Val Gly Phe Val Gln Leu Gln Asn Arg Lys 
            580                 585                 590         


Gln Ala Glu Asn Ser Lys Arg Pro Lys Ala Phe Ala Phe Glu Ala Val 
        595                 600                 605             


Arg Pro Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala Tyr Val 
    610                 615                 620                 


Gln Ser Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys Ala Thr 
625                 630                 635                 640 


Asp Glu Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val Phe Ile 
                645                 650                 655     


Lys Gly Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe Val Gln 
            660                 665                 670         


Val Pro Gln Pro Gln Leu Thr Thr Thr Asp Ser Asn Gln Gln Lys Ala 
        675                 680                 685             


Asp Lys Leu Asn Gln Leu Glu Ala Ser Ile Thr Ala Asp Cys Lys Leu 
    690                 695                 700                 


Thr Ala Gln Tyr Ala Lys Thr Asp Asp Ala Thr His Ile Ala Phe Tyr 
705                 710                 715                 720 


Val Phe Cys Lys Leu Leu Asp Ala Gly His Leu Ser Asn Leu Arg Asn 
                725                 730                 735     


Glu Leu Ile Lys Phe Arg Gly Ser Val Lys Asp Phe Asp Phe His His 
            740                 745                 750         


Leu Leu Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val Val Pro 
        755                 760                 765             


Thr Asp Tyr Arg Asp Leu Tyr Ser Ser Gly Ala Asp Cys Leu Ala Arg 
    770                 775                 780                 


Leu Arg Pro Phe Ile Glu Gln Gly Ala Asp Ile Lys Asn Trp Ser Asp 
785                 790                 795                 800 


Leu Tyr Val Gln Thr Asp Lys Gln Thr Pro Val Ile His Ala Gly Ile 
                805                 810                 815     


Glu Leu Ser Val Lys Tyr Gly Thr Thr Ala Leu Leu Glu Gln Leu Ile 
            820                 825                 830         


Thr Cys Asn Pro Lys Phe Arg Val Met Glu Asp Asn Phe Thr Lys Trp 
        835                 840                 845             


Ser Ala Gln Lys Lys Glu Ile Glu Glu Lys Val Asn Lys His Thr Asn 
    850                 855                 860                 


Leu His Gln Gln Trp Val Glu Ala Lys Glu Lys Asp Asp Arg Glu Arg 
865                 870                 875                 880 


Val Lys Ser Lys Lys Asn Phe Val Arg Glu Tyr Val Lys Lys Asn Tyr 
                885                 890                 895     


Val Asp Tyr Ile Asn Asn Cys Ile Glu Ile Asn Asn Tyr Asn Trp Leu 
            900                 905                 910         


Asp Asn Lys Leu His Phe Val His Leu Asn His Leu His His Leu Thr 
        915                 920                 925             


Ile Asp Ile Leu Gly Arg Met Ala Gly Phe Val Ala Leu Trp Glu Arg 
    930                 935                 940                 


Asp Phe Gln Tyr Ile Thr Lys Tyr Thr Ala Ala Lys Glu Gly Thr Asp 
945                 950                 955                 960 


Ala Leu Ser Phe Asp Gly Gly Leu Pro Arg Leu Lys Asp Lys Gln Glu 
                965                 970                 975     


Tyr Tyr Asn Lys Leu Phe Leu Ser Asp Lys Tyr Thr Lys Val Arg Asn 
            980                 985                 990         


His Ile Ala His Phe Asn Tyr Leu  Thr Lys Asp Ala Ala  Asp Phe Ala 
        995                 1000                 1005             


Leu Leu  Asp Leu Ile Asn Glu  Leu Arg Glu Leu Leu  His Tyr Gly 
    1010                 1015                 1020             


Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ala Phe Ile  Asp Leu Phe 
    1025                 1030                 1035             


Glu Lys  His Gly Met Ile Leu  Lys Leu Lys Leu Asn  Thr Asp His 
    1040                 1045                 1050             


Gln Leu  Val Val Glu Ser Ile  Glu Pro Lys Lys Ile  Tyr His Leu 
    1055                 1060                 1065             


Gly Ser  Thr Ala Lys Asp Lys  Pro Glu Tyr Gln Tyr  Thr Thr Asn 
    1070                 1075                 1080             


Gln Val  Met Thr Val Tyr Cys  Asn Met Cys Arg Ser  Leu Leu Glu 
    1085                 1090                 1095             


Met Lys  Lys 
    1100     


<210>  352
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  352

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Asn Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Tyr Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asn Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asn Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Gly Leu Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Lys Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Ile Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Ser Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Lys Ile Pro Tyr Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Lys Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Gln Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asp Glu Ile Gly Lys Phe Leu Asn Phe Asn Gly Asn 
            820                 825                 830         


Lys Val Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Lys Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Lys Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Lys Ile Glu Lys Asn His Lys Met Gln Glu Asn Leu Tyr Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Glu 
        915                 920                 925             


Ser Tyr Lys Gln Ala Ile Lys Asn Ile Glu Glu Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Ser Leu Leu Leu 
945                 950                 955                 960 


Arg Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Glu Asn Lys  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Lys Phe Tyr Lys Glu  Leu His Gln 
    1010                 1015                 1020             


Asn Asp  Glu Val Lys Ile Asn  Lys Tyr Ser Ser Ala  Asn Ile Lys 
    1025                 1030                 1035             


Val Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Val Lys Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Glu 
    1100                 1105                 1110             


Ile Gln  Ser Leu Lys Ser Glu  Glu Ile Val His Leu  Lys Lys Leu 
    1115                 1120                 1125             


Lys Leu  Lys Asp Asn Asp Lys  Lys Lys Glu Pro Ile  Lys Thr Tyr 
    1130                 1135                 1140             


Arg Asn  Ser Lys Glu Leu Cys  Lys Leu Val Lys Val  Met Phe Glu 
    1145                 1150                 1155             


Tyr Lys  Met Glu Glu Lys Lys  Ser Glu Asn 
    1160                 1165             


<210>  353
<211>  1228
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  353

Met Asn Asn Lys Ser Phe Asn Tyr Lys Ala Met Gln Phe Ile Pro Asp 
1               5                   10                  15      


Ile Gln Asn Pro Lys Thr Asn Asp Ala Val Asn Tyr Arg Thr Asp Arg 
            20                  25                  30          


Asp Asn Val Tyr Asn Lys Asn Lys Tyr Tyr Asp Lys Gln Thr Lys Ser 
        35                  40                  45              


Lys Ser Lys Lys Phe Ile Tyr Glu Lys Ile Ala Ile Pro Gln Asn Glu 
    50                  55                  60                  


Gln Asn Ile Val Ile Ser Ala Leu Val Asn Cys Ser Leu Arg Lys Ser 
65                  70                  75                  80  


Leu Arg Lys Asp Val Ser Tyr Lys Thr Lys Ser Gly Glu Ile Lys Thr 
                85                  90                  95      


Tyr Asn Leu Pro Glu Leu Val Lys Lys Ser Met Lys Phe Tyr Cys Leu 
            100                 105                 110         


Glu Gly Gln Arg Glu Pro Asp Glu Lys Glu Lys Tyr Glu Met Tyr Ile 
        115                 120                 125             


Leu Phe Ser Tyr Met Lys Glu Asp Lys Arg Thr Lys Asn Thr Asp Leu 
    130                 135                 140                 


Leu Val Lys Ser Ile Ser Asn Gln Asn Thr Lys Val Lys Val Glu Asp 
145                 150                 155                 160 


Ile Asp Gly Asn Lys Leu Leu Lys Leu Ser Ile Ala Asp Thr Lys Lys 
                165                 170                 175     


Lys Pro Leu Trp Glu Tyr Leu Ile Lys Tyr Ala Asp Ser Ser Arg Gln 
            180                 185                 190         


Arg Glu Leu Met Tyr Asp Ile Arg Lys Lys Ile Ile Leu Tyr Val Ala 
        195                 200                 205             


Gly Ile Glu Glu Tyr Glu Asn Ile Lys Glu Asp Ser Gly Leu Ser Lys 
    210                 215                 220                 


Val Ser Trp Ser Lys Tyr Asn Ile Ser Asp Asn Lys Met Phe Phe Asp 
225                 230                 235                 240 


Ile Asn Ser Cys Thr Asp Lys Arg Lys Gln Asn Leu Glu Ile Lys Ile 
                245                 250                 255     


Arg Glu Ala Asn Ile Glu His Tyr Arg Asn Ala Ser Ser Lys Leu Cys 
            260                 265                 270         


Asp Asp Glu Ser Ile Phe Trp Phe Gln His Phe Glu Gly Val Ile Glu 
        275                 280                 285             


Thr Leu Phe Ser Lys Lys Ser Lys Ile Ser Glu Glu Arg Leu Gly Cys 
    290                 295                 300                 


Ala Tyr Ile Cys Asp Tyr Leu Trp Lys Asp Phe Leu Ser Tyr Leu Ala 
305                 310                 315                 320 


Ala Lys Tyr Ile Asp Leu Gly Lys Gly Val Tyr His Phe Thr Met Lys 
                325                 330                 335     


Asp Lys Leu Asp Met Leu Asn Lys Asn Glu Ala Val Thr Asp Leu Arg 
            340                 345                 350         


Phe Gly Ile Val Ser Glu Lys Tyr Glu Lys Gly Ile Thr Ser Phe Asp 
        355                 360                 365             


Tyr Glu Arg Ile Lys Ala Glu Glu Glu Leu Asp Arg Asn Ile Ala Ala 
    370                 375                 380                 


Tyr Val Thr Phe Ala Ala Asp Ile Phe Ala Lys Ser Val Ile Lys Ser 
385                 390                 395                 400 


Asp Tyr Arg Thr Lys Lys Asp Asn Asn Ser Asp Val Leu Gln Tyr Ser 
                405                 410                 415     


Asp Lys Glu Phe Arg Asn Ser Glu Val Ile Arg Asp Asn Ala Glu Lys 
            420                 425                 430         


Asn Ile Leu Gln Tyr Trp Gly Gly Tyr Ser Arg Trp Gly Thr Glu Asn 
        435                 440                 445             


Ser Lys Leu Pro Glu Asn Asn Lys Val Ser Asp Phe Gly Lys Leu Asp 
    450                 455                 460                 


Val Ser Asp Leu Cys Ile Asp Ile Lys Lys His Leu Ala Gly Ile Arg 
465                 470                 475                 480 


Asn Ser Ser Val His Tyr Thr Thr Lys Ile Lys Asn Glu Ser Ala Ala 
                485                 490                 495     


Asp Gly Ser Asn Val Lys Ile Leu Phe Glu Lys Asp Leu Ala Asp Ile 
            500                 505                 510         


Asn Ile Ile Tyr Ala Asp Lys Tyr Tyr Ser Asn Asn Val Trp Met Phe 
        515                 520                 525             


Tyr Ser Leu Glu Asp Ile Asn Lys Leu Ile Ala Phe Leu Tyr Lys Glu 
    530                 535                 540                 


Lys Arg Val Ile Arg Gln Val Gln Ile Pro Ser Phe Ser His Ile Leu 
545                 550                 555                 560 


Lys Arg Lys Ala Met Gln Asp Val Ile Asn Glu Ile Phe Lys Asp Asp 
                565                 570                 575     


Phe Asp Glu Asn Ile Val Asn Pro Glu Leu Lys Glu Lys Tyr Arg Asn 
            580                 585                 590         


Ser Leu Tyr Phe Met Leu Lys Glu Ile Tyr Tyr Asn Ala Phe Ile Ile 
        595                 600                 605             


Gln Pro Glu Leu Lys Glu Lys Phe Lys Asp Lys Ile Lys Thr Met Lys 
    610                 615                 620                 


Ser Glu Leu Tyr Asn Lys Leu Lys Thr Ile Asp Lys Lys Glu Tyr Lys 
625                 630                 635                 640 


Ala Leu Tyr Cys Met Leu Ser Asn Glu Glu Ser Ala Leu Lys Asn Phe 
                645                 650                 655     


Ala Asp Arg Ile Tyr Ser Val Asp Gly Asp Asn Val Ser Phe Ala Asp 
            660                 665                 670         


Ile Cys Lys Ile Leu Met Thr Asp Tyr Asn Met Gln Asn Gln Glu Lys 
        675                 680                 685             


Lys Asn Ile Glu Ser Met Glu Gln Lys Lys Lys Asn Lys Gly Lys Asp 
    690                 695                 700                 


Glu Asn Tyr Lys His Phe Pro Leu Leu Leu His Lys Val Leu Lys Glu 
705                 710                 715                 720 


Leu Phe Ile Glu Tyr Leu Lys Gln Thr His Glu Leu Glu Phe Leu Arg 
                725                 730                 735     


Asn Asn Ile Cys Ile Lys Ser Asp Val Thr Met Glu Ser Phe Glu Ser 
            740                 745                 750         


Gln Ile Lys Gly Val Glu Ile Tyr Lys Asp Leu Lys Glu Lys Ile Asp 
        755                 760                 765             


Lys Asn Asn Ser Leu Leu Asp Trp Tyr Val Ile Ala His Phe Leu Met 
    770                 775                 780                 


Pro Lys Gln Leu Asn His Leu Ile Gly Asn Ile Lys Asn Tyr Ile Gln 
785                 790                 795                 800 


Phe Ala Thr Asn Ile Asp Lys Arg Ala Glu Ser Val Lys Asn Leu Thr 
                805                 810                 815     


Glu Ser Gly Met Val Lys Arg Ile Gln Tyr Tyr Asp Asp Ile Val Arg 
            820                 825                 830         


Thr Leu Glu Phe Ser Ala Gln Tyr Ile Gly Lys Ile Ser Asn Asn Ile 
        835                 840                 845             


Asn Asp Tyr Phe Asn Ser Glu Asp Glu Tyr Val Ser Phe Leu Ser Lys 
    850                 855                 860                 


Tyr Val Gly Phe Ile Asn Asp Lys Ser Glu Asp Val Leu Thr Glu Leu 
865                 870                 875                 880 


Lys Asp Phe Cys Arg Glu Lys Ile Asn Asn Gly Ser Gln Ile Ile Gly 
                885                 890                 895     


Ile Tyr Tyr Gly Gly Asp Asn Val Ile Ile Asn Arg Asn Val Ile Tyr 
            900                 905                 910         


Ala Gln Met Tyr Ser Asn Ala Glu Val Phe Ser Asn Ile Tyr Lys Lys 
        915                 920                 925             


Val Thr Lys Asn Asp Ile Ile Asn Tyr Tyr Glu Lys Gln Asn Asp Leu 
    930                 935                 940                 


Lys Asp Val Phe Lys Ser Gly Val Cys Gln Asn Asp Asp Glu Gln Arg 
945                 950                 955                 960 


Ser Leu Cys Glu Phe Gln Gln Leu Lys Asn Arg Ile Glu Leu Thr Glu 
                965                 970                 975     


Leu Ser Thr Tyr Ala Asp Met Val Asn Asp Phe Met Ala Gln Phe Val 
            980                 985                 990         


Glu Trp Ala Tyr Leu Arg Glu Arg  Asp Leu Met Tyr Phe  Gln Leu Gly 
        995                 1000                 1005             


Ile His  Tyr Ile Arg Leu Phe  Tyr Ser Asp Asn Val  Leu Asp Glu 
    1010                 1015                 1020             


Lys Tyr  His Lys Leu Arg Asp  Asn Val Ile Asp Ile  Glu Glu Gly 
    1025                 1030                 1035             


Ala Leu  Leu Tyr Gln Ile Val  Ala Met Tyr Asp Tyr  Glu Leu Arg 
    1040                 1045                 1050             


Ile Phe  Glu Thr Asp Asn Ser  Gly Asn Ala Lys Arg  Ile Gly Gln 
    1055                 1060                 1065             


Gly Gly  Pro Gly Lys Ser Ile  Pro Val Phe Leu Lys  Lys Tyr Cys 
    1070                 1075                 1080             


Asn Gly  Thr Asp Val Tyr Glu  Cys Gly Leu Glu Leu  Phe Glu Asp 
    1085                 1090                 1095             


Ile Asn  Gln His Glu His Ile  Ile Arg Phe Arg Asn  Asp Ile Ala 
    1100                 1105                 1110             


His Met  Arg Tyr Met Ser Asn  Gln Ala Met Asn Ile  Met Ser Ile 
    1115                 1120                 1125             


Val Ser  Asn Ile Tyr Lys Ser  Phe Phe Val Tyr Asp  Thr Lys Leu 
    1130                 1135                 1140             


Lys Lys  Ser Ile Ser Leu Val  Phe Lys Asn Ile Leu  Met Arg Tyr 
    1145                 1150                 1155             


Gly Val  Ile Ala Asp Leu Val  Ile Ser Tyr Asn Asn  Lys Asn Gln 
    1160                 1165                 1170             


Ser Ile  Lys Asp Asp Met Asp  Ile Asn Ile Ile Asn  Ile Lys Asn 
    1175                 1180                 1185             


Leu Lys  Ser Asp Lys Tyr Val  Tyr Lys Ile Val Asn  Glu Asp Ile 
    1190                 1195                 1200             


Val Lys  Gln Val Glu Ile Glu  Ile Arg Asn Gln Val  Phe Leu Glu 
    1205                 1210                 1215             


Gln Leu  His Asn Leu Leu Tyr  Phe Ser Arg 
    1220                 1225             


<210>  354
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  354

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Thr Glu Asn Lys Asn Glu Glu Gln Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Arg Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Leu Lys Lys Asn Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Lys Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Cys Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Ile Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Gln Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Ala Leu Glu Gly Glu Ser 
    450                 455                 460                 


Val Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Glu Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Ala Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Arg Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Lys Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Lys Gly Asp Lys Glu Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Glu Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Ser Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Lys Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Glu Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Val Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Thr Gln  
    1355                 1360 


<210>  355
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  355

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Ile Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Phe Asp Phe Lys Leu  Leu Asn 
    1400                 1405                 1410         


<210>  356
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  356

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Lys Ile Pro Tyr Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Leu Lys Glu Leu Lys Glu Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn Tyr Thr Met Gln Gln Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Lys Lys Asp Glu Lys Phe Asn Asp Glu Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asn Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Lys Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Lys Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Glu  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  357
<211>  1139
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  357

Met Cys Met Lys Ile Thr Lys Ile Asp Gly Ile Ser His Lys Lys Tyr 
1               5                   10                  15      


Lys Glu Lys Gly Lys Leu Ile Lys Ser Asn Glu Ile Glu Lys Asp Val 
            20                  25                  30          


Thr Glu Glu Arg Phe Tyr Asp Ile Lys Thr Lys Thr Thr Glu Leu Phe 
        35                  40                  45              


Leu Lys Thr Leu Asp Phe Tyr Val Lys Asn Tyr Glu Gln Cys Glu Glu 
    50                  55                  60                  


Gln Asn Lys Glu Arg Arg Glu Lys Ala Lys Asn Tyr Phe Ser Lys Val 
65                  70                  75                  80  


Lys Leu Ile Ile Glu Asn Arg Lys Ile Thr Ile Phe Asn Glu Asn Thr 
                85                  90                  95      


Glu Lys Ile Glu Ile Glu Gly Phe Asn Glu Tyr Asp Val Arg Asp Glu 
            100                 105                 110         


Lys Tyr Phe Asn Val Leu Asn Lys Ile Leu Lys Glu Glu Asn Cys Thr 
        115                 120                 125             


Glu Glu Asp Leu Glu Val Phe Glu Asn Asp Leu Gln Lys Arg Ile Gly 
    130                 135                 140                 


Arg Ile Lys Ser Ile Lys Asn Ser Leu Glu Glu Asn Lys Ala His Phe 
145                 150                 155                 160 


Lys Lys Glu Ser Val Asn Asn Thr Ala Asp Arg Val Lys Gly Asn Asn 
                165                 170                 175     


Lys Lys Ser Leu Phe Tyr Glu Tyr Tyr Arg Ile Ser Ser Lys His Gln 
            180                 185                 190         


Glu Tyr Ala Asn Asn Ile Phe Glu Ala Phe Asp Lys Leu Tyr Ser Asn 
        195                 200                 205             


Ser His Glu Ala Met Asn Asn Leu Phe Ser Glu Ile Thr Lys Asp Ser 
    210                 215                 220                 


Lys Asn Arg Asn Ile Arg Lys Ile Arg Glu Ala Tyr His Glu Ile Leu 
225                 230                 235                 240 


Asn Lys Asn Lys Thr Glu Phe Gly Glu Glu Leu Tyr Lys Lys Ile Gln 
                245                 250                 255     


Asp Asn Ile Ser Asn Phe Asp Lys Leu Leu Glu Ile Glu Pro Glu Ile 
            260                 265                 270         


Lys Glu Leu Thr Lys Ser Gln Ile Phe Tyr Lys Tyr Tyr Ile Asp Lys 
        275                 280                 285             


Val Asn Leu Asp Glu Thr Ser Ile Lys His Cys Phe Cys His Leu Val 
    290                 295                 300                 


Glu Ile Glu Val Asn Gln Leu Leu Lys Asn Tyr Val Tyr Ser Lys Arg 
305                 310                 315                 320 


Asn Ile Asn Lys Glu Lys Leu Glu Asn Ile Phe Glu Tyr Cys Lys Leu 
                325                 330                 335     


Arg Asn Leu Val Lys Asn Lys Leu Val Asn Lys Leu Asn Asn Tyr Ile 
            340                 345                 350         


Arg Asn Cys Gly Lys Tyr Asn Ala Tyr Ile Ser Asn Asn Asp Val Val 
        355                 360                 365             


Val Asn Ser Glu Lys Ile Ser Glu Ile Arg Thr Lys Glu Ala Phe Leu 
    370                 375                 380                 


Arg Ser Ile Ile Gly Val Ser Ser Ser Ala Tyr Phe Ser Leu Arg Asn 
385                 390                 395                 400 


Ile Leu Asn Thr Asp Asn Thr Gln Asp Ile Thr Asn Lys Val Asp Lys 
                405                 410                 415     


Glu Val Asp Lys Leu Tyr Gln Glu Asn Lys Lys Ile Glu Leu Glu Glu 
            420                 425                 430         


Ile Leu Lys Leu Phe Phe Gly Asn Tyr Phe Asp Ile Asn Asn Gln Gln 
        435                 440                 445             


Glu Ile Lys Val Phe Leu Met Asn Ile Asp Lys Ile Ile Ser Ser Ile 
    450                 455                 460                 


Arg His Glu Ile Ile His Phe Lys Met Glu Thr Asn Ala Gln Asn Ile 
465                 470                 475                 480 


Phe Asp Phe Asn Asn Val Asn Leu Gly Asn Thr Ala Lys Asn Ile Phe 
                485                 490                 495     


Ser Asn Glu Ile Asn Glu Glu Lys Ile Lys Phe Lys Ile Phe Lys Gln 
            500                 505                 510         


Leu Asn Ser Ala Asn Ile Phe Asn Tyr Leu Ser Asn Lys Asp Ile Arg 
        515                 520                 525             


Glu Tyr Met Gly Lys Val Val Phe Ser Phe Ile Asn Arg Asn Ile Ser 
    530                 535                 540                 


Phe Val Pro Ser Phe Thr Lys Ile Tyr Asn Arg Val Gln Asn Leu Ala 
545                 550                 555                 560 


Asn Ser Leu Glu Ile Lys Glu Trp Lys Ile Pro Asp Glu Ser Glu Gly 
                565                 570                 575     


Lys Asp Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Lys Phe 
            580                 585                 590         


Leu Asp Lys Phe Leu Asn Glu Glu Asn Gly Ile Phe Ile Ser Ile Lys 
        595                 600                 605             


Asp Lys Ile Ile Glu Leu Asn Lys Asn Lys Asn Gln Asn Glu Asp Lys 
    610                 615                 620                 


His Cys Lys Phe Lys Lys Phe Glu Ser Val Asn Glu Lys Asn Pro Lys 
625                 630                 635                 640 


Lys Tyr Leu Glu Ile Ile Gln Ser Leu Tyr Met Ile Asn Ile Glu Lys 
                645                 650                 655     


Ile Asp Ser Glu Arg Lys Asn Val Phe Leu Asp Phe Ile Gln Arg Ile 
            660                 665                 670         


Phe Leu Lys Gly Phe Phe Glu Phe Ile Lys Asn Asp Tyr Asn Tyr Leu 
        675                 680                 685             


Leu Glu Leu Lys Lys Val Gln Asp Lys Lys Asn Ile Phe Asp Ser Lys 
    690                 695                 700                 


Met Ser Glu Tyr Ile Ala Gly Glu Lys Thr Leu Glu Asp Met Glu Glu 
705                 710                 715                 720 


Ile Thr Glu Ile Ile Gln Asp Ile Lys Ile Thr Glu Ile Asp Lys Ile 
                725                 730                 735     


Leu Asn Gln Thr Asp Arg Ile Asn Cys Phe Tyr Leu Leu Leu Lys Leu 
            740                 745                 750         


Leu Asn Tyr Lys Glu Ile Thr Glu Leu Lys Gly Asn Leu Glu Lys Tyr 
        755                 760                 765             


Gln Ile Leu Ser Lys Thr Asn Ile Tyr Glu Lys Glu Leu Met Leu Leu 
    770                 775                 780                 


Asn Ile Val Asn Leu Asp Asn Asn Lys Val Lys Ile Glu Asn Phe Lys 
785                 790                 795                 800 


Ile Ser Ala Glu Glu Ile Gly Lys Phe Ile Glu Glu Ile Asn Lys Asn 
                805                 810                 815     


Lys Lys Ile Lys Thr Phe Glu Glu Leu Arg Asn Phe Glu Lys Gly Glu 
            820                 825                 830         


Asn Thr Gly Glu Tyr Tyr Asn Ile Tyr Ser Asp Asp Lys Asn Ile Lys 
        835                 840                 845             


Asn Ile Arg Asn Leu Tyr Asn Ile Lys Lys Tyr Gly Met Leu Asp Leu 
    850                 855                 860                 


Leu Glu Lys Ile Ser Glu Lys Thr Asn Tyr Cys Ile Lys Lys Lys Asp 
865                 870                 875                 880 


Leu Glu Glu Tyr Ser Lys Leu Arg Lys Gln Leu Glu Asp Glu Lys Thr 
                885                 890                 895     


Asn Phe Tyr Glu Ile Gln Lys Tyr Leu His Phe Lys Tyr Gln Lys Lys 
            900                 905                 910         


Pro Lys Lys Ile Leu Trp Lys Asn Asn Lys Asn Asp Tyr Glu Lys Tyr 
        915                 920                 925             


Lys Lys Ser Ile Glu Asn Ile Glu Lys Tyr Val His Leu Lys Asn Lys 
    930                 935                 940                 


Ile Glu Phe Asn Glu Leu Asn Leu Leu Gln Ser Leu Leu Leu Lys Ile 
945                 950                 955                 960 


Leu His Arg Leu Val Gly Phe Thr Ser Ile Trp Glu Arg Asp Leu Arg 
                965                 970                 975     


Phe Arg Leu Thr Gly Glu Phe Pro Asp Glu Leu Asp Val Glu Asp Ile 
            980                 985                 990         


Phe Asp His Arg Lys Arg Tyr Lys  Gly Thr Gly Gly Gly  Ile Cys Lys 
        995                 1000                 1005             


Lys Tyr  Asp Arg Phe Ile Asn  Thr His Thr Glu Tyr  Lys Asn Asn 
    1010                 1015                 1020             


Asn Lys  Met Glu Asn Val Lys  Phe Asp Asp Asn Thr  Pro Val Arg 
    1025                 1030                 1035             


Asn Tyr  Ile Ala His Phe Asn  Tyr Leu Pro Thr Pro  Lys Tyr Ser 
    1040                 1045                 1050             


Ile Leu  Lys Met Ile Glu Lys  Leu Arg Lys Leu Leu  Asp Tyr Asp 
    1055                 1060                 1065             


Arg Lys  Leu Lys Asn Ala Val  Met Lys Ser Ile Lys  Asp Ile Leu 
    1070                 1075                 1080             


Glu Glu  Tyr Gly Phe Lys Ala  Glu Phe Ile Ile Asn  Ser Asp Lys 
    1085                 1090                 1095             


Glu Ile  Ile Leu Asn Pro Val  Lys Pro Val Glu Ile  Ile His Leu 
    1100                 1105                 1110             


Gly Lys  Glu Asp Leu Lys Ser  Arg Arg Asn Ser Glu  Asp Leu Cys 
    1115                 1120                 1125             


Lys Leu  Val Lys Ala Met Leu  Glu Tyr Ser Lys 
    1130                 1135                 


<210>  358
<211>  1191
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  358

Met Lys Val Thr Lys Ile Asp Gly Leu Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ile Glu Asp Ala Ser Gln Lys Asn Glu Thr 
            20                  25                  30          


Leu Glu Arg Leu Glu Asn Leu Lys Gly Ile Lys Leu Gly Asn Tyr Ile 
        35                  40                  45              


Lys Asn Pro Asp Lys Thr Lys Asn Lys Asp Asn Lys Lys Arg Arg Lys 
    50                  55                  60                  


Gly Leu Lys Glu Tyr Phe Ser Glu Ile Thr Leu Arg Lys Glu Asn Glu 
65                  70                  75                  80  


Lys Tyr Val Leu Leu Lys Gly Lys Lys Leu Lys Lys Ile Asn Asn Asp 
                85                  90                  95      


Ile Lys Asp Thr Asp Ile Lys Ala Lys Asp Lys Lys Glu Glu Val Phe 
            100                 105                 110         


Asp Ile Leu Lys Glu Ile Leu Lys Leu Asn Leu Leu Ala Asn Asp Ala 
        115                 120                 125             


Glu Glu Lys Ile Gln Phe Asp Ser Ile Lys Leu Lys Asn Val Phe Gly 
    130                 135                 140                 


Lys Asp Phe Val Lys Lys Glu Leu Gln Ile Lys Ser Ile Glu Glu Ser 
145                 150                 155                 160 


Leu Glu Lys Asn Lys Ala Asp Tyr Arg Lys Glu Phe Ile Glu Thr Glu 
                165                 170                 175     


Asn His Lys Tyr Gly Asn Val Lys Gly Lys Asn Lys Arg Ser Arg Ile 
            180                 185                 190         


Tyr Glu Tyr Tyr Lys Lys Ser Glu Asn His Lys Lys Phe Glu Asp Asn 
        195                 200                 205             


Ile Arg Glu Ala Phe Glu Lys Leu Tyr Thr Glu Glu Asn Ile Lys Glu 
    210                 215                 220                 


Leu Tyr Ser Lys Ile Glu Gln Val Leu Lys Lys Thr His Leu Lys Ser 
225                 230                 235                 240 


Ile Val Arg Glu Phe Tyr Gln Asn Glu Ile Ile Gly Glu Ser Glu Phe 
                245                 250                 255     


Ser Lys Lys Asn Gly Asp Gly Ile Ser Ile Leu Tyr Asn Gln Ile Lys 
            260                 265                 270         


Asp Ser Ile Lys Lys Glu Lys Asn Phe Ile Glu Phe Ile Glu Asn Ile 
        275                 280                 285             


Gly Asn Leu Glu Leu Lys Asp Leu Thr Lys Ser Gln Ile Phe Tyr Lys 
    290                 295                 300                 


Tyr Phe Leu Glu Asn Glu Glu Leu Asn Asp Glu Asn Ile Lys Phe Val 
305                 310                 315                 320 


Phe Cys Tyr Phe Val Glu Ile Glu Val Ser Asp Leu Leu Lys Gly Asn 
                325                 330                 335     


Val Tyr Lys Ala Ser Lys Ile Tyr Glu Asn Lys Ile Lys Asn Ile Phe 
            340                 345                 350         


Glu Tyr Gly Lys Leu Lys Asn Leu Ile Val Tyr Lys Leu Glu Asn Lys 
        355                 360                 365             


Leu Asn Asn Tyr Val Arg Asn Cys Gly Lys Tyr Asn Tyr His Met Glu 
    370                 375                 380                 


Asn Gly Asp Ile Ala Thr Ser Asp Ile Asn Met Arg Asn Arg Gln Thr 
385                 390                 395                 400 


Glu Ala Phe Leu Arg Ser Met Ile Gly Val Ser Ser Phe Gly Tyr Phe 
                405                 410                 415     


Ser Leu Arg Asn Ile Leu Gly Val Asn Asp Asp Asp Phe Tyr Glu Ile 
            420                 425                 430         


Glu Glu Asp Leu Thr Glu Glu Glu Arg Lys Asn Glu Ser Asn Val Leu 
        435                 440                 445             


Lys Lys Ala Lys Glu Asp Ile Thr Ser Lys Ser Ile Phe Glu Lys Val 
    450                 455                 460                 


Val Asp Lys Ser Phe Glu Lys Lys Gly Ile His Ser Ile Arg Glu Asn 
465                 470                 475                 480 


Val Lys Met Phe Tyr Gly Asp Ser Phe Asp Lys Ala Asn Glu Asp Glu 
                485                 490                 495     


Leu Lys Gln Phe Phe Val Asn Met Leu Asn Ala Ile Thr Ser Ile Arg 
            500                 505                 510         


His Arg Val Val His Tyr Asn Met Asn Thr Asn Ser Glu Asn Ile Phe 
        515                 520                 525             


Asn Phe Ser Asp Ile Glu Val Ser Arg Leu Leu Lys Ser Ile Phe Glu 
    530                 535                 540                 


Lys Glu Thr Asp Lys Arg Glu Leu Lys Leu Lys Ile Phe Arg Gln Leu 
545                 550                 555                 560 


Asn Ser Ala Gly Val Phe Asp Tyr Trp Glu Asp Trp Glu Ile Glu Lys 
                565                 570                 575     


Tyr Leu Lys Asn Ile Glu Phe Lys Phe Val Asn Lys Asn Ile Pro Phe 
            580                 585                 590         


Val Pro Ser Phe Thr Lys Leu Tyr Asn Arg Ile Asp Asp Leu Lys Gly 
        595                 600                 605             


Asn Asn Ala Leu Lys Leu Gly Ala Ile Asn Ile Pro Lys Arg Lys Glu 
    610                 615                 620                 


Ala Arg Asp Ser Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu 
625                 630                 635                 640 


Phe Ile Glu Lys Phe Val Asn Asn Asn Asp Asn Phe Glu Lys Ile Phe 
                645                 650                 655     


Arg Glu Ile Ile Glu Ile Asn Lys Asn Ala Gly Thr Asn Thr Lys Thr 
            660                 665                 670         


Lys Phe Tyr Lys Leu Glu Lys Phe Glu Thr Leu Lys Ala Asn Thr Pro 
        675                 680                 685             


Thr Glu Tyr Leu Glu Lys Leu Gln Ser Leu His Lys Ile Asn Tyr Asp 
    690                 695                 700                 


Lys Glu Lys Val Glu Glu Ala Lys Asp Ile Tyr Val Asp Phe Val Gln 
705                 710                 715                 720 


Lys Ile Phe Leu Lys Gly Phe Ile Asn Tyr Leu Gln Lys Ser Asn Ser 
                725                 730                 735     


Leu Arg Pro Leu Asn Leu Leu Asn Leu Lys Lys Asp Glu Val Ile Asn 
            740                 745                 750         


Ser Glu Lys Ser Ser Tyr Asp Glu Lys Leu Lys Gln Trp Glu Asn Asn 
        755                 760                 765             


Gly Ser Asn Leu Ser Lys Met Pro Glu Glu Ile Tyr Glu Tyr Ile Lys 
    770                 775                 780                 


Lys Ile Gln Ile Asn Lys Ile Asn Tyr Ser Asp Arg Met Ser Ile Phe 
785                 790                 795                 800 


Tyr Leu Leu Leu Lys Leu Ile Asp His Lys Glu Leu Thr Asn Leu Arg 
                805                 810                 815     


Gly Asn Leu Glu Lys Tyr Glu Ser Met Asn Lys Asn Lys Ile Tyr Ser 
            820                 825                 830         


Glu Glu Leu Asn Ile Val Asn Leu Val Ser Leu Asp Asn Asn Lys Val 
        835                 840                 845             


Arg Ala Asn Phe Ser Val Glu Ala Glu Asp Ile Gly Lys Phe Leu Lys 
    850                 855                 860                 


Thr Glu Thr Leu Ile Lys Asp Ala Arg Gln Leu Asn Asn Phe Ser Glu 
865                 870                 875                 880 


Arg Phe Ser Asp Gly Glu Asn Val Ile Lys His Arg Ser Phe Tyr Asn 
                885                 890                 895     


Ile Lys Lys Tyr Gly Ile Leu Asp Leu Leu Glu Lys Ile Val Ala Lys 
            900                 905                 910         


Ala Asp Leu Lys Ile Thr Lys Glu Glu Ile Lys Lys Tyr Glu Asn Leu 
        915                 920                 925             


Gln Lys Glu Leu Glu Lys Asn Asp Phe Tyr Lys Ile Gln Glu Lys Ile 
    930                 935                 940                 


His Arg Lys Tyr Asn Gln Lys Pro Asn Leu Ile Ser Arg Thr Glu Asn 
945                 950                 955                 960 


Lys Lys Asp Phe Asn Asp Tyr Lys Lys Ala Ile Glu Asn Ile Gln Asn 
                965                 970                 975     


Tyr Thr Gln Leu Lys Asn Lys Ile Glu Phe Asn Asp Leu Asn Leu Leu 
            980                 985                 990         


Gln Ser Leu Leu Phe Arg Ile Leu  His Arg Phe Ala Gly  Tyr Thr Ser 
        995                 1000                 1005             


Leu Trp  Glu Arg Asp Leu Gln  Phe Lys Leu Lys Gly  Glu Phe Pro 
    1010                 1015                 1020             


Glu Asp  Lys Tyr Ile Asp Glu  Ile Phe Asn Ser Asp  Gly Asn Asn 
    1025                 1030                 1035             


Asn Gln  Lys Tyr Lys Asn Gly  Gly Ile Ala Asp Lys  Tyr Ala Asp 
    1040                 1045                 1050             


Phe Leu  Ile Glu Lys Glu Glu  Glu Lys Ser Gly Glu  Ile Leu Lys 
    1055                 1060                 1065             


Lys Asn  Gln Arg Ile Lys Arg  Lys Lys Lys Ile Lys  Glu Asp Leu 
    1070                 1075                 1080             


Glu Ile  Arg Asn Tyr Ile Ala  His Phe Asn Tyr Phe  Pro Asp Ala 
    1085                 1090                 1095             


Thr Lys  Ser Ile Leu Glu Leu  Leu Glu Glu Leu Arg  Glu Leu Leu 
    1100                 1105                 1110             


Lys Tyr  Asp Arg Lys Leu Lys  Asn Ala Val Met Lys  Ser Val Lys 
    1115                 1120                 1125             


Asp Ile  Phe Lys Glu Tyr Gly  Phe Ile Val Glu Phe  Gly Ile Ser 
    1130                 1135                 1140             


His Glu  Ser Asn Ser Lys Lys  Ile Lys Val Val Asn  Val Glu Ser 
    1145                 1150                 1155             


Glu Lys  Ile Lys His Leu Lys  Asn Asn Gly Leu Val  Thr Thr Arg 
    1160                 1165                 1170             


Asn Ser  Glu Asp Leu Cys Asp  Leu Val Lys Val Met  Leu Glu Tyr 
    1175                 1180                 1185             


Lys Lys  Ser 
    1190     


<210>  359
<211>  1330
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  359

Met Lys Arg Glu Lys Asn Ile Thr Ile Met Lys Ile Ser Lys Val Asn 
1               5                   10                  15      


His Arg Arg Thr Ala Val Ala Leu Asn Gly Asp Lys Ser Glu Leu Gly 
            20                  25                  30          


Gly Ile Leu Tyr Glu Ala Pro Val Gln Lys Asp Lys Asn Gly Asn Tyr 
        35                  40                  45              


Asn Asp Val Ile Ala Glu Thr Gly Lys Val Val Asn Glu Ala Leu Asp 
    50                  55                  60                  


Lys Lys Ser Arg Leu Tyr Thr Pro Phe Asn Asn Gln Lys Val Ile Ile 
65                  70                  75                  80  


Asp Lys Asn Leu Gln Arg Tyr Ala Asn Asn Leu Lys Arg Cys Tyr Ile 
                85                  90                  95      


Asn Phe Val Lys Gln Tyr Val Asn Asn Lys Ser Phe Asn Tyr Lys Ala 
            100                 105                 110         


Met Gln Phe Ile Pro Asp Ile Gln Asn Pro Lys Thr Asn Asp Ala Val 
        115                 120                 125             


Asn Tyr Arg Thr Asp Arg Asp Asn Val Tyr Asn Lys Asn Lys Tyr Tyr 
    130                 135                 140                 


Asp Lys Gln Thr Lys Ser Lys Ser Lys Lys Phe Ile Tyr Glu Lys Ile 
145                 150                 155                 160 


Val Ile Pro Gln Asn Glu Gln Asn Ile Val Ile Ser Ala Leu Val Asn 
                165                 170                 175     


Cys Ser Leu Arg Lys Ser Leu Arg Lys Asp Val Ser Tyr Lys Thr Lys 
            180                 185                 190         


Ser Gly Glu Ile Lys Thr Tyr Asn Leu Pro Glu Leu Val Lys Lys Ser 
        195                 200                 205             


Met Arg Phe Tyr Cys Leu Glu Gly Gln Arg Glu Pro Asp Glu Lys Glu 
    210                 215                 220                 


Lys Tyr Glu Met Tyr Ile Leu Phe Ser Tyr Met Lys Glu Asp Lys Arg 
225                 230                 235                 240 


Thr Lys Asn Thr Asp Leu Leu Val Lys Ser Ile Ser Asn Gln Asn Thr 
                245                 250                 255     


Lys Val Lys Val Glu Asp Ile Asp Gly Asn Lys Leu Leu Lys Leu Ser 
            260                 265                 270         


Ile Ala Asp Thr Lys Lys Lys Pro Leu Trp Glu Tyr Leu Ile Lys Tyr 
        275                 280                 285             


Ala Asp Ser Ser Arg Gln Arg Glu Leu Met Tyr Asp Ile Arg Lys Lys 
    290                 295                 300                 


Ile Ile Leu Tyr Val Ala Gly Ile Glu Glu Tyr Glu Asn Ile Lys Glu 
305                 310                 315                 320 


Asp Ser Gly Leu Ser Lys Val Ser Trp Ser Lys Tyr Asn Ile Ser Asp 
                325                 330                 335     


Asn Lys Met Phe Phe Asp Ile Asn Ser Cys Thr Asp Lys Arg Lys Gln 
            340                 345                 350         


Asn Leu Glu Ile Lys Ile Arg Glu Ala Asn Ile Glu His Tyr Arg Asn 
        355                 360                 365             


Ala Ser Ser Lys Leu Cys Asp Asp Glu Ser Ile Phe Trp Phe Gln His 
    370                 375                 380                 


Phe Glu Gly Val Ile Glu Thr Leu Phe Ser Lys Lys Ser Lys Ile Ser 
385                 390                 395                 400 


Glu Glu Arg Leu Gly Cys Ala Tyr Ile Cys Asp Tyr Leu Trp Lys Asp 
                405                 410                 415     


Phe Leu Ser Tyr Leu Ala Ala Lys Tyr Ile Asp Leu Gly Lys Gly Val 
            420                 425                 430         


Tyr His Phe Thr Met Lys Asp Lys Leu Asp Met Leu Asn Lys Asn Glu 
        435                 440                 445             


Ala Ile Thr Asp Leu Arg Phe Gly Ile Val Ser Glu Lys Tyr Glu Lys 
    450                 455                 460                 


Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Glu Leu 
465                 470                 475                 480 


Asp Arg Asn Ile Ala Ala Tyr Val Thr Phe Ala Ala Asp Ile Phe Ala 
                485                 490                 495     


Lys Ser Val Ile Lys Ser Asp Tyr Arg Thr Lys Lys Asp Asn Asn Ser 
            500                 505                 510         


Asp Val Leu Gln Tyr Ser Asp Lys Glu Phe Arg Asn Ser Glu Val Ile 
        515                 520                 525             


Arg Asp Asn Ala Glu Lys Asn Ile Leu Gln Tyr Trp Gly Gly Tyr Ser 
    530                 535                 540                 


Arg Trp Gly Thr Glu Asn Ser Lys Leu Pro Glu Asn Asn Lys Val Ser 
545                 550                 555                 560 


Asp Phe Asp Lys Leu Asp Val Ser Asp Leu Cys Ile Asp Ile Lys Lys 
                565                 570                 575     


His Leu Ala Gly Ile Arg Asn Ser Ser Val His Tyr Thr Thr Lys Ile 
            580                 585                 590         


Lys Asn Glu Ser Ala Ala Asp Gly Ser Asn Val Lys Ile Leu Phe Glu 
        595                 600                 605             


Lys Asp Leu Ala Asp Ile Asn Ile Ile Tyr Ala Asp Lys Tyr Tyr Ser 
    610                 615                 620                 


Asn Asn Val Trp Met Phe Tyr Ser Leu Glu Asp Ile Asn Lys Leu Ile 
625                 630                 635                 640 


Ala Phe Leu Tyr Lys Glu Lys Arg Val Ile Arg Gln Val Gln Ile Pro 
                645                 650                 655     


Ser Phe Ser Arg Ile Leu Lys Arg Lys Ala Met Gln Asp Val Ile Asn 
            660                 665                 670         


Glu Ile Phe Lys Asp Asp Phe Asp Glu Asn Ile Val Asn Pro Glu Leu 
        675                 680                 685             


Lys Glu Lys Tyr Arg Asn Ser Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
    690                 695                 700                 


Tyr Asn Ala Phe Ile Ile Gln Pro Glu Leu Lys Glu Lys Phe Lys Asp 
705                 710                 715                 720 


Lys Ile Lys Thr Met Lys Ser Glu Leu Tyr Asn Lys Leu Lys Thr Ile 
                725                 730                 735     


Asp Lys Lys Glu Tyr Lys Ala Leu Tyr Cys Met Leu Ser Asn Glu Glu 
            740                 745                 750         


Ser Ala Leu Lys Asn Phe Ala Asp Arg Ile Tyr Ser Val Asp Gly Asp 
        755                 760                 765             


Asn Val Ser Phe Ala Asp Ile Cys Lys Ile Leu Met Thr Asp Tyr Asn 
    770                 775                 780                 


Met Gln Asn Gln Glu Lys Lys Asn Ile Glu Ser Met Glu Gln Lys Lys 
785                 790                 795                 800 


Lys Asn Lys Gly Lys Asp Glu Asn Tyr Lys His Phe Pro Leu Leu Leu 
                805                 810                 815     


His Lys Val Leu Lys Glu Leu Phe Ile Glu Tyr Leu Lys Gln Thr His 
            820                 825                 830         


Glu Leu Glu Phe Leu Arg Asn Asn Ile Cys Ile Lys Ser Asp Val Thr 
        835                 840                 845             


Met Glu Ser Phe Glu Ser Gln Ile Lys Gly Val Glu Ile Tyr Lys Asp 
    850                 855                 860                 


Leu Lys Glu Lys Ile Asp Lys Asn Asn Ser Leu Leu Asp Trp Tyr Val 
865                 870                 875                 880 


Ile Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asn 
                885                 890                 895     


Ile Lys Asn Tyr Ile Gln Phe Ala Thr Asn Ile Asp Lys Arg Ala Glu 
            900                 905                 910         


Ser Val Lys Asn Leu Thr Glu Ser Gly Met Val Lys Arg Ile Gln Tyr 
        915                 920                 925             


Tyr Asp Asp Ile Val Arg Thr Leu Glu Phe Ser Ala Gln Tyr Ile Gly 
    930                 935                 940                 


Lys Ile Ser Asn Asn Ile Asn Asp Tyr Phe Asn Ser Glu Asp Glu Tyr 
945                 950                 955                 960 


Val Ser Phe Leu Ser Lys Tyr Val Gly Phe Ile Asn Asp Lys Ser Glu 
                965                 970                 975     


Asp Val Leu Thr Glu Leu Lys Asp Phe Cys Arg Glu Lys Ile Asn Asn 
            980                 985                 990         


Gly Ser Gln Ile Ile Gly Ile Tyr  Tyr Gly Gly Asp Asn  Val Ile Ile 
        995                 1000                 1005             


Asn Arg  Asn Val Ile Tyr Ala  Gln Met Tyr Ser Asn  Ala Glu Val 
    1010                 1015                 1020             


Phe Ser  Asn Ile Tyr Lys Lys  Val Thr Lys Asn Asp  Ile Ile Asn 
    1025                 1030                 1035             


Tyr Tyr  Glu Lys Gln Asn Asp  Leu Lys Asp Val Phe  Lys Ser Gly 
    1040                 1045                 1050             


Val Cys  Gln Asn Glu Asp Glu  Gln Arg Ser Leu Cys  Glu Phe Gln 
    1055                 1060                 1065             


Gln Leu  Lys Asn Arg Ile Glu  Leu Thr Glu Leu Ser  Thr Tyr Ala 
    1070                 1075                 1080             


Asp Met  Val Asn Asp Phe Met  Ala Gln Phe Val Glu  Trp Ala Tyr 
    1085                 1090                 1095             


Leu Arg  Glu Arg Asp Leu Met  Tyr Phe Gln Leu Gly  Ile His Tyr 
    1100                 1105                 1110             


Ile Arg  Leu Phe Tyr Ser Asp  Asn Val Leu Asp Glu  Lys Tyr His 
    1115                 1120                 1125             


Lys Leu  Ser Asp Asn Val Ile  Asp Ile Glu Glu Gly  Ala Leu Leu 
    1130                 1135                 1140             


Tyr Gln  Ile Val Ala Met Tyr  Asp Tyr Glu Leu Arg  Ile Phe Glu 
    1145                 1150                 1155             


Thr Asp  Asn Ser Gly Asn Ala  Lys Arg Ile Gly Gln  Gly Gly Pro 
    1160                 1165                 1170             


Gly Lys  Ser Ile Pro Val Phe  Leu Lys Lys Tyr Cys  Asn Gly Thr 
    1175                 1180                 1185             


Asp Val  Tyr Glu Cys Gly Leu  Glu Leu Phe Glu Asp  Ile Asn Gln 
    1190                 1195                 1200             


His Glu  His Ile Ile Arg Phe  Arg Asn Asp Ile Ala  His Met Arg 
    1205                 1210                 1215             


Tyr Met  Ser Asn Gln Ala Met  Asn Ile Met Ser Ile  Val Ser Asn 
    1220                 1225                 1230             


Ile Tyr  Lys Ser Phe Phe Ala  Tyr Asp Thr Lys Leu  Lys Lys Ser 
    1235                 1240                 1245             


Ile Ser  Leu Val Phe Lys Asn  Ile Leu Met Arg Tyr  Gly Val Ile 
    1250                 1255                 1260             


Ala Asp  Leu Val Phe Ser Tyr  Asn Asn Lys Asn Gln  Ser Ile Lys 
    1265                 1270                 1275             


Asp Asp  Met Asp Ile Asn Ile  Ile Asn Ile Lys Asn  Leu Lys Ser 
    1280                 1285                 1290             


Asp Lys  Tyr Val Tyr Lys Ile  Val Asn Glu Asp Ile  Val Lys Gln 
    1295                 1300                 1305             


Val Glu  Ile Glu Ile Arg Asn  Gln Val Phe Leu Glu  Gln Leu His 
    1310                 1315                 1320             


Asn Leu  Leu Tyr Phe Ser Arg  
    1325                 1330 


<210>  360
<211>  1678
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  360

Met Glu Asp Val Glu Gly Ala Val Tyr Pro Val Asp Leu His Ser Asp 
1               5                   10                  15      


Gly Asp Gly Glu Arg Asp His Gly Ile Ile Ser Pro Val Lys Glu Lys 
            20                  25                  30          


Val Glu Glu Thr Leu Pro Glu Phe Ile Cys Lys Gly Thr Tyr Lys Gly 
        35                  40                  45              


Val Pro Leu Cys Asp Asp Asn Lys Asn Arg Ile Arg Gly Arg Lys Gly 
    50                  55                  60                  


Lys Tyr His Leu Phe Val Leu Leu Lys Ser Asp Ala Gly Lys Lys His 
65                  70                  75                  80  


Leu Leu Ala Glu Asn Ala Asn Met Leu Val Lys Asp Asp Trp Ala Ala 
                85                  90                  95      


Asn Arg Tyr Phe His Met Ala Ser Ser Val Val Asn Arg Leu Ile Phe 
            100                 105                 110         


His Asn Pro Leu Tyr Ser Gly Gly Gln Met Pro Ala Ile Lys Leu Asp 
        115                 120                 125             


Ile Ala Thr Arg Ala Thr Gly Asp Ile Asp Lys Met Gly Asn Gly Ile 
    130                 135                 140                 


Lys Glu Glu Phe Gln Lys Gln Lys Tyr Arg Val Lys Lys Gly Asn Asn 
145                 150                 155                 160 


Arg Glu Tyr Tyr Ser Ile Met Asn Ala Asp Ile Tyr Arg Thr Leu Ile 
                165                 170                 175     


Ala Gln Glu Met Val Asn Ser Gly Lys Ile Asn Ile Arg Ile Glu Lys 
            180                 185                 190         


Leu Asn Ile Lys Ser Ile Cys Tyr Asp Ser Ser Gly Gln Gly Met Glu 
        195                 200                 205             


Phe Leu Tyr Leu Ala Asp Ser Ile Cys Ser Ile Leu Gly Tyr Arg Leu 
    210                 215                 220                 


Thr Lys Thr Gly Ser Ser Ala Asp Asp Trp Leu Val Gln Ile Lys Glu 
225                 230                 235                 240 


Arg Ile Cys Asp Leu Asn Arg Asp Asn Glu Asn Leu Ile Phe Gly Tyr 
                245                 250                 255     


Asp Glu Ile Asp Asn Tyr Phe Ser Asn Ala Trp Gly Gln Phe Glu Asn 
            260                 265                 270         


Lys Asp Met Phe Lys Ala Leu Ser Val Ile Tyr Asp Ala Lys Trp Met 
        275                 280                 285             


Lys Gly Glu Phe Ala Lys His Tyr Gln Asn Glu Trp Phe Pro Phe Leu 
    290                 295                 300                 


Glu Glu Gln Leu Arg Arg Arg Ala Thr Pro Glu Leu Phe Leu Gln Ser 
305                 310                 315                 320 


Val Asp Gln Leu His Ala Phe Leu Gln Thr Asn Asn Ile Asp Gln Glu 
                325                 330                 335     


Lys Leu Leu Tyr Ile Met Gln Gln Leu Glu Ser Met Val Glu Gly Val 
            340                 345                 350         


Ser Asn Arg Phe Lys Ser Lys Glu Ser Lys Glu Arg Ala Leu Tyr Lys 
        355                 360                 365             


Leu Tyr Asp Ala Gly Val Ala Val Tyr Cys His Ile Gly Asp Ala Thr 
    370                 375                 380                 


Lys Ala Gln Gly Tyr Tyr Glu Lys Cys Arg Leu His Val Val Tyr Val 
385                 390                 395                 400 


Ser Leu Asp Asp Tyr Met Lys Thr Asn Asn Arg Leu Ile Val Leu Leu 
                405                 410                 415     


Glu Asp Ala Phe Gln Trp Asp Glu Ala Leu Asn Lys Ala Lys Glu Asn 
            420                 425                 430         


Leu Asp Ile Leu Gln Met Ile Ala Lys Gly Ala Thr Val Ser Pro Lys 
        435                 440                 445             


Asn Phe Leu Asp Cys Leu Gln Lys Ser Ala Glu Thr Ile Lys Phe Glu 
    450                 455                 460                 


Arg Arg Lys Lys Lys Ser Gly Asn Val Val Trp Val Pro Val Lys Leu 
465                 470                 475                 480 


Glu Glu Asp Tyr Lys Lys Tyr Gly Thr Ser Leu Gln Glu Gln Val Glu 
                485                 490                 495     


Gln Ala Val His Phe Asn Ile Lys Arg Ser Leu Ser Lys Glu Thr Val 
            500                 505                 510         


Ile His Ser Val Cys Lys Ile Leu Ile Ser Phe Phe Gln Lys Asn Gln 
        515                 520                 525             


Ile Thr Leu Lys Glu Glu Glu Ser Arg Leu Leu Ile Gln Ala Leu Asp 
    530                 535                 540                 


Lys Asp Ile Arg Lys Glu Lys Gln Leu Lys Tyr Ile Glu Lys Ser Ile 
545                 550                 555                 560 


Gln Leu Gln Asn Thr Lys Val Gln Pro Val Gln Val Asp Gly Lys Thr 
                565                 570                 575     


Val Leu Ala Leu Ser Gly Ala Lys His Pro Lys Lys Lys Ile Ile Phe 
            580                 585                 590         


Asp Phe Leu Val Arg Tyr Ala Asn Ala Ser Gln Ser Asp Gln Glu Asn 
        595                 600                 605             


Met Leu Ile Gln Met Arg Lys Trp Ile Leu Leu Phe Val Cys Gly Glu 
    610                 615                 620                 


Gln Ala Tyr Lys Glu Ala Glu Glu Lys Gly Ile Ser Thr Arg Gly Phe 
625                 630                 635                 640 


Ala Ala Glu His Gly Asp Ile Pro Gly Thr Phe Gly Gly Asp Val Tyr 
                645                 650                 655     


Ser Lys Ile Ser Asp Leu Gln Glu Ile Lys Lys Gln Asp Lys Gly Ala 
            660                 665                 670         


Ser Glu Arg Leu Lys Val Ser Lys Leu Lys Lys Glu Ile Ala Ala Met 
        675                 680                 685             


Ile Asn Asp Thr Leu Thr Thr Val Tyr Arg Glu Ile Lys Gly Met Asp 
    690                 695                 700                 


Gly Val Ala Glu Glu Asp Met Phe Trp Ile Glu Tyr Ile Gln Lys Glu 
705                 710                 715                 720 


Val Gln Lys Val Leu Leu Lys Lys Asn Lys Leu Ala Thr Gly Ile Glu 
                725                 730                 735     


Tyr Lys Ile Gln Asn Lys Tyr Leu Cys Asn Gln Val Trp Lys Asn Trp 
            740                 745                 750         


Val Ser Phe Ile Ala Gly Lys Tyr Val Asp Met Gly Lys Gly Val Tyr 
        755                 760                 765             


His Phe Val Met Pro Glu Cys Asn Ser Asn Ile Asn Glu Leu Glu Val 
    770                 775                 780                 


Cys Glu Val Gln Asp Phe Tyr Lys Lys Gly Ile Ser Ser Phe Asp Tyr 
785                 790                 795                 800 


Glu Met Ile Lys Ala Glu Glu Thr Leu Glu Arg Asp Met Ala Val Ala 
                805                 810                 815     


Val Thr Phe Ala Val Asn Asn Phe Ser Arg Ala Ile Ile Lys Lys Glu 
            820                 825                 830         


Ser Glu Arg Thr Thr Ser Gln Asn Glu Asp Val Leu Gln Tyr Thr Glu 
        835                 840                 845             


Lys Glu Phe Glu Lys Tyr Cys Asp Gly Glu Asn Ile His Lys Asn Ile 
    850                 855                 860                 


Leu Gln Tyr Phe Gly Gly Ile Ser Lys Trp Glu Asp Cys Glu Ile Val 
865                 870                 875                 880 


His Ala Ser Gly Phe Glu Val Phe Asp Thr Ile Lys Lys Asn Ile Asn 
                885                 890                 895     


Cys Val Arg Asn Ala Ser Tyr His Tyr Ser Gln Asn Leu Glu Lys Arg 
            900                 905                 910         


Glu Val Arg Asn Lys Tyr Val Asp Met Leu Cys Arg His Glu Val Asp 
        915                 920                 925             


Asn Tyr Thr Glu Ile Ile Lys Asp Lys Tyr Tyr Ser Asn Asn Leu Tyr 
    930                 935                 940                 


Arg Phe Tyr Pro Glu Ser Thr Leu Lys Arg Leu Met Asp Glu Leu Tyr 
945                 950                 955                 960 


Ser Glu Val Lys Glu Arg Pro Ala Gln Ile Pro Ala Phe Asn Arg Ile 
                965                 970                 975     


Ile Asn Lys Gln Lys Ile Ala Ala Phe Leu Ser Thr Val Ile Lys Gly 
            980                 985                 990         


Asn Lys Leu Lys Lys Val Ile Gly  Asn Val Glu Asp Ala  Ser Leu Phe 
        995                 1000                 1005             


Tyr Pro  Ala Met Ile Phe Leu  Leu Lys Glu Ile Tyr  Tyr Asn Ala 
    1010                 1015                 1020             


Phe Ile  Cys Asn Glu Asn Cys  Lys Lys Trp Val Glu  Glu Ala Ala 
    1025                 1030                 1035             


Leu Lys  Asn Ala Glu Asn Glu  Lys Asp Lys Asn Lys  Lys Glu Ala 
    1040                 1045                 1050             


Asn Lys  Asn Phe Ile Leu Arg  Leu Glu Gln Leu His  Thr Glu Ser 
    1055                 1060                 1065             


Phe Gly  Asp Met Cys Gln Gln  Leu Met Thr Ala Leu  Asp Leu Gln 
    1070                 1075                 1080             


Asn Asn  Arg Asp His Arg Val  Asn Thr Asn Ala Asp  Gln Leu Lys 
    1085                 1090                 1095             


Tyr Lys  His Phe Arg Ile Leu  Leu Tyr Asn Ala Ile  Tyr Glu Ala 
    1100                 1105                 1110             


Phe Ala  Asn Phe Ile Lys Ser  Lys Glu Gln Lys Leu  Tyr Ser Leu 
    1115                 1120                 1125             


Tyr Asp  Ala Val Arg Glu Pro  Val Leu Gln Thr Asn  Leu Lys Thr 
    1130                 1135                 1140             


Arg Glu  Glu Phe Leu Ser Gly  Trp Thr Ala His Arg  Tyr Asp Thr 
    1145                 1150                 1155             


Lys Ile  Asp Lys Ile Thr Gly  Asn Ser Ile Leu Ser  Ala Trp Tyr 
    1160                 1165                 1170             


Val Thr  Ser His Phe Leu Ala  Pro Arg Gln Val Asn  His Leu Ala 
    1175                 1180                 1185             


Gly Ser  Met Lys Asn Tyr Arg  Gln Phe Val Asn Asp  Ile Gly Asp 
    1190                 1195                 1200             


Arg Arg  Asn Lys Val Glu Ser  Lys Gln Ser Tyr Arg  Lys Thr Glu 
    1205                 1210                 1215             


Ile Tyr  Glu Asp Val Val Met  Val Leu Glu Leu Val  Asp Ala Ser 
    1220                 1225                 1230             


Ser Gly  Gln Ile Ser Asn Glu  Val Lys Asp Tyr Phe  Gly Ser Asp 
    1235                 1240                 1245             


Glu Glu  Tyr Ala Arg His Leu  Ser Lys Tyr Val Asp  Phe Ser Asp 
    1250                 1255                 1260             


Glu Lys  Ala Lys Asn Asn Met  Glu Glu Pro Ser Cys  Arg Met Leu 
    1265                 1270                 1275             


Leu Gln  Leu Phe Ser Glu Asn  Arg Gln Gln Thr Gly  Asp Gly Asp 
    1280                 1285                 1290             


Met Ile  Asp Ile Tyr Tyr Lys  Asn Asn Val Ile Leu  Asn Arg Asn 
    1295                 1300                 1305             


Ile Val  Leu Ser Lys Met Tyr  Gly Leu Asp Ile Cys  Glu Asn Gly 
    1310                 1315                 1320             


Trp Trp  Gln Lys Val Thr Leu  Glu Asn Asp Ile Leu  Asn Tyr Tyr 
    1325                 1330                 1335             


Lys Leu  Lys Arg Glu Leu Ser  Ser Gly Ser Lys Phe  Thr Gly Thr 
    1340                 1345                 1350             


Ala Val  Phe Glu Lys Gly Arg  Cys Glu Phe Pro Glu  Glu Gln Glu 
    1355                 1360                 1365             


Lys Leu  Lys Lys Phe Gln Asn  Ile Lys Asn Arg Val  Glu Leu Leu 
    1370                 1375                 1380             


Asp Val  Met Thr Tyr Glu Glu  Ile Leu Ile Asp Leu  Tyr Ser Gln 
    1385                 1390                 1395             


Leu Val  Ser Trp Ala Tyr Met  Arg Glu Arg Asp Leu  Leu Tyr Met 
    1400                 1405                 1410             


Gln Leu  Gly Val Ala Tyr Leu  Ala Leu Asn Tyr Gly  Asp Lys Ser 
    1415                 1420                 1425             


Tyr Arg  Thr Arg Ser Arg Glu  Met Phe Gly Asp Asp  Arg Leu Asn 
    1430                 1435                 1440             


Ser Met  Glu Gly Pro Gly Pro  Val Asn Ile Lys Asn  Gly Ala Leu 
    1445                 1450                 1455             


Leu Tyr  Gln Leu Ile Ala Met  Asn Asn Pro Cys Met  Thr Leu Tyr 
    1460                 1465                 1470             


Glu Val  Glu Asn Gly Lys Ala  Thr Pro Ala Lys Lys  Ala Gly Asn 
    1475                 1480                 1485             


Ser Ile  Gly Ala Arg Val Gly  Cys Leu Tyr Lys Gly  Tyr Leu Asn 
    1490                 1495                 1500             


Cys Arg  Glu Glu Val Tyr Lys  Asn Gly Leu Tyr Phe  Phe Glu Asn 
    1505                 1510                 1515             


Tyr Gln  Leu His Asp Tyr Ile  Val Lys His Val Arg  Asn Glu Ile 
    1520                 1525                 1530             


Asp His  Phe Lys Tyr Phe Arg  Lys Pro Val Lys Ser  Leu Leu Glu 
    1535                 1540                 1545             


Leu Tyr  Ser Glu Ile Tyr Thr  Tyr Phe Phe Thr Tyr  Asp Lys Lys 
    1550                 1555                 1560             


Leu Gln  Lys Ser Val Thr Phe  Ile Leu Leu Asn Ile  Leu Glu Lys 
    1565                 1570                 1575             


Tyr Phe  Val Arg Ala Lys Ile  Gln Met Gly Tyr Lys  Lys Val Glu 
    1580                 1585                 1590             


Val Lys  Asn Asp Lys Lys Glu  Met Ile Pro Val Ile  Glu Thr Asp 
    1595                 1600                 1605             


Ile Asn  Ile Glu Lys Ala His  Ser Leu Tyr Met Phe  Tyr Asn Gln 
    1610                 1615                 1620             


Ile Lys  Tyr Arg Glu Gln Asp  Ser Lys Glu Asp Lys  Lys Ala Tyr 
    1625                 1630                 1635             


Asn Asp  Tyr Lys Ser Arg Tyr  Asp Leu Asp Ile Gly  Lys Gly Val 
    1640                 1645                 1650             


Leu Lys  Leu Glu Ala Arg Asp  Asp Leu Phe Val Lys  Gln Leu Leu 
    1655                 1660                 1665             


Glu Leu  Leu Ser Tyr Lys Glu  Ser Met Arg 
    1670                 1675             


<210>  361
<211>  1167
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  361

Met Lys Val Thr Lys Val Gly Gly Ile Ser His Lys Lys Tyr Thr Ser 
1               5                   10                  15      


Glu Gly Arg Leu Val Lys Ser Glu Ser Glu Glu Asn Arg Thr Asp Glu 
            20                  25                  30          


Arg Leu Ser Ala Leu Leu Asn Met Arg Leu Asp Met Tyr Ile Lys Asn 
        35                  40                  45              


Pro Ser Asn Thr Glu Thr Lys Glu Asn Lys Lys Arg Ile Gly Lys Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Met Val Tyr Leu Lys Asp Asn Thr Leu 
65                  70                  75                  80  


Ser Leu Lys Asn Gly Lys Lys Glu Asn Ile Asp Arg Glu Tyr Ser Glu 
                85                  90                  95      


Thr Asp Ile Ser Glu Tyr Asp Val Arg Asp Ser Lys Asn Phe Ala Val 
            100                 105                 110         


Leu Lys Lys Ile Tyr Leu Asn Glu Asn Val Asn Ser Glu Glu Leu Glu 
        115                 120                 125             


Val Phe Arg Lys Asp Ile Lys Lys Lys Leu Asn Lys Ile Asn Ser Leu 
    130                 135                 140                 


Lys Tyr Ser Phe Glu Lys Asn Lys Ala Asn Tyr Gln Lys Ile Asn Glu 
145                 150                 155                 160 


Asn Asn Ile Glu Lys Val Glu Gly Lys Ser Lys Arg Asn Ile Ile Tyr 
                165                 170                 175     


Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asp Ala Tyr Val Ser Asn Val 
            180                 185                 190         


Lys Glu Ala Phe Asp Lys Leu Tyr Lys Glu Glu Asp Ile Ala Lys Leu 
        195                 200                 205             


Val Leu Lys Ile Glu Asn Leu Thr Lys Leu Glu Lys Ser Lys Ile Arg 
    210                 215                 220                 


Glu Phe Tyr His Glu Ile Ile Gly Arg Lys Asn Asp Lys Glu Asn Phe 
225                 230                 235                 240 


Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Met Lys Glu 
                245                 250                 255     


Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser Gln Val 
            260                 265                 270         


Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Glu Asn Val 
        275                 280                 285             


Lys Tyr Val Phe Cys His Phe Val Glu Ile Glu Met Ser Lys Leu Leu 
    290                 295                 300                 


Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp Lys Val 
305                 310                 315                 320 


Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu Asn Lys 
                325                 330                 335     


Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys Tyr Asn 
            340                 345                 350         


Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile Ala Arg 
        355                 360                 365             


Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val Ser Ser 
    370                 375                 380                 


Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn Lys Asp 
385                 390                 395                 400 


Asp Ile Thr Gly Lys Met Arg Gly Lys Thr Arg Ile Glu Ser Lys Thr 
                405                 410                 415     


Gly Glu Glu Lys Tyr Ile Pro Gly Glu Val Asp Gln Ile Tyr Tyr Glu 
            420                 425                 430         


Asn Lys Gln Asn Glu Val Lys Asn Lys Leu Lys Met Phe Tyr Gly Tyr 
        435                 440                 445             


Asp Phe Asp Met Asp Asn Lys Lys Glu Ile Glu Asp Phe Phe Ala Asn 
    450                 455                 460                 


Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe Asn 
465                 470                 475                 480 


Leu Asp Leu Asp Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Val Pro 
                485                 490                 495     


Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys Lys 
            500                 505                 510         


Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe Arg 
        515                 520                 525             


Tyr Leu Glu Lys Asp Arg Ile Leu Asp Tyr Leu Arg Ser Thr Arg Phe 
    530                 535                 540                 


Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys Leu 
545                 550                 555                 560 


Tyr Asp Arg Ile Asp Asp Leu Lys Ile Ser Leu Asn Ile Tyr Trp Lys 
                565                 570                 575     


Thr Pro Lys Thr Asn Asp Asp Ile Lys Thr Lys Glu Ile Thr Asp Ala 
            580                 585                 590         


Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Lys Phe Leu Asp Tyr 
        595                 600                 605             


Phe Met Ser Arg Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Val Ile 
    610                 615                 620                 


Lys Leu Asn Lys Asn Asn Lys Lys Asn Val Lys Thr Gly Phe Tyr Lys 
625                 630                 635                 640 


Leu Gln Lys Phe Glu Asn Leu Glu Ala Arg Ser Pro Lys Glu Tyr Leu 
                645                 650                 655     


Ala Lys Val Gln Ser Leu Tyr Ile Ile Asn Val Ala Asn Gln Asp Glu 
            660                 665                 670         


Glu Glu Lys Asn Thr Tyr Ile Asp Phe Ile Gln Lys Val Phe Leu Lys 
        675                 680                 685             


Gly Phe Ile Thr Tyr Leu Ala Asn Asn Arg Arg Leu Ser Leu Met Tyr 
    690                 695                 700                 


Ile Gly Ser Asp Glu Glu Val Asn Asn Ser Leu Ala Glu Lys Lys Gln 
705                 710                 715                 720 


Glu Phe Asp Lys Phe Trp Arg Lys Tyr Glu Glu Asn Asn Asp Ile Glu 
                725                 730                 735     


Ile Pro Asp Glu Ile Asn Glu Phe Leu Lys Glu Ile Lys Leu Gly Lys 
            740                 745                 750         


Ile Leu Lys Asn Ser Ala Lys Leu Asn Ile Phe Tyr Leu Ile Leu Lys 
        755                 760                 765             


Leu Leu Asn Asn Lys Glu Phe Thr Asn Leu Lys Gly Asn Leu Glu Lys 
    770                 775                 780                 


Tyr His Ser Ala Asn Glu Val Asn Ile Phe Ser Asp Glu Leu Glu Leu 
785                 790                 795                 800 


Ile Asn Phe Leu Asn Leu Asp Asn Asn Lys Val Lys Glu Asp Phe Glu 
                805                 810                 815     


Phe Glu Ala Asp Glu Ile Gly Lys Phe Leu Asn Phe Asn Gly Asn Lys 
            820                 825                 830         


Ile Lys Asn Arg Glu Glu Leu Lys Lys Phe Asp Thr Thr Lys Met Tyr 
        835                 840                 845             


Phe Tyr Lys Glu Asn Ile Ile Lys Tyr Arg Ala Tyr Tyr Asn Ile Lys 
    850                 855                 860                 


Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala Gly 
865                 870                 875                 880 


Tyr Lys Ile Ser Ile Glu Glu Leu Lys Lys Tyr Ser Asn Lys Lys Asn 
                885                 890                 895     


Glu Ile Glu Lys Asn His Lys Met Gln Glu Asn Leu His Arg Lys Tyr 
            900                 905                 910         


Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Glu Ser 
        915                 920                 925             


Tyr Lys Gln Ala Ile Lys Asn Ile Glu Glu Tyr Thr His Leu Lys Asn 
    930                 935                 940                 


Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu Arg 
945                 950                 955                 960 


Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp Leu 
                965                 970                 975     


Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu Glu 
            980                 985                 990         


Ile Phe Asn Phe Glu Asn Lys Lys  Asn Met Lys Tyr Lys  Ser Gly Gln 
        995                 1000                 1005             


Ile Val  Glu Lys Tyr Ile Lys  Phe Tyr Lys Glu Leu  His Gln Asn 
    1010                 1015                 1020             


Asp Glu  Val Lys Ile Asn Lys  Tyr Ser Ser Ala Asn  Ile Lys Val 
    1025                 1030                 1035             


Leu Lys  Gln Glu Lys Lys Asp  Leu Tyr Ile Arg Asn  Tyr Ile Ala 
    1040                 1045                 1050             


His Phe  Asn Tyr Ile Pro His  Ala Glu Ile Ser Leu  Leu Glu Val 
    1055                 1060                 1065             


Leu Glu  Asn Leu Arg Lys Leu  Leu Ser Tyr Asp Arg  Lys Leu Lys 
    1070                 1075                 1080             


Asn Ala  Val Met Lys Ser Val  Val Asp Ile Leu Lys  Glu Tyr Gly 
    1085                 1090                 1095             


Phe Val  Val Lys Phe Lys Ile  Gly Ala Asp Lys Lys  Ile Glu Ile 
    1100                 1105                 1110             


Gln Ser  Leu Lys Ser Glu Glu  Ile Val His Leu Lys  Lys Leu Lys 
    1115                 1120                 1125             


Leu Lys  Asp Asn Asp Lys Lys  Lys Glu Pro Ile Lys  Thr Tyr Arg 
    1130                 1135                 1140             


Asn Ser  Lys Glu Leu Cys Lys  Leu Val Lys Val Met  Phe Glu Tyr 
    1145                 1150                 1155             


Lys Met  Glu Glu Lys Ser Ser  Glu Lys 
    1160                 1165         


<210>  362
<211>  1349
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  362

Met Lys Ile Ser Lys Val Asn His Thr Lys Ser Ala Val Ala Lys Asn 
1               5                   10                  15      


Glu Gly Met Ile Lys Gly Ile Leu Tyr Gln Asp Pro Gly Ser Glu Glu 
            20                  25                  30          


Asp Leu Gln Lys Arg Phe Ser Thr Leu Asn Arg Asn Ala Gln Arg Leu 
        35                  40                  45              


Tyr Lys Ile Leu Asn Gln Val Gln Val Gly Glu Lys Gln Asn Arg Arg 
    50                  55                  60                  


Ser Arg Tyr Glu Val Ile Ile Asn Gly Lys Asp Gly Leu Asn Asn Lys 
65                  70                  75                  80  


Leu Gln Asp Leu Leu Phe Ile Arg Gln Asp Asn Arg Leu Ala Val Lys 
                85                  90                  95      


Asn Ser Glu Ala Val Leu Lys Lys Leu His Ser Trp Asn Leu Gln Val 
            100                 105                 110         


Lys Gly Lys Glu Val Ser Asn Asp Asp Leu Asp Asp Ile Leu Thr Leu 
        115                 120                 125             


Tyr Leu Arg Lys Ser Leu Arg Lys Gly Lys Ala Gly Leu Arg Thr Leu 
    130                 135                 140                 


Phe Arg Asn Ser Gly Asn Thr Asp Ile Ser Gln Glu Asp Gln Glu Lys 
145                 150                 155                 160 


Ile Ser Glu Phe Val Thr Ile Leu Arg Glu Asp Tyr Thr Lys Asn Asn 
                165                 170                 175     


Phe Gly Lys Lys Ile Arg Lys Ser Ile Glu Asn Gln Asn Leu Ile Val 
            180                 185                 190         


Gln Pro Val Gln Thr Gly Asn Arg Gly Val Leu Ala Leu Ser Thr Lys 
        195                 200                 205             


Lys Asp Ser Arg Ser Gly Arg Glu Lys Gln Ser Phe Ser Asp Phe Leu 
    210                 215                 220                 


Thr Asn Tyr Ala Asn Leu Asp Ser Glu Lys Arg Met Asp Leu Leu Arg 
225                 230                 235                 240 


Lys Leu Arg Arg Leu Val Asp Leu Tyr Phe Asn Ala Asp Gly Asn Thr 
                245                 250                 255     


Asp Ser Leu Thr Leu Pro Lys Glu Val Asn Ile Glu Pro Asp Tyr Asn 
            260                 265                 270         


Val Trp Ala Thr His Glu Ala Gly Lys Thr Asn Asn Lys Thr Phe Ala 
        275                 280                 285             


Glu Tyr Pro Glu Ile Leu Ser Gln Gly Asp Asp Ser Asn Ser Gly Glu 
    290                 295                 300                 


Arg Lys Thr Leu Asp Ser Val Glu Val Arg Glu Ala Arg Gly Ser Leu 
305                 310                 315                 320 


Lys Glu Ser Ile Arg Lys Arg Asn Ile Glu Cys Tyr Arg Lys Ser Leu 
                325                 330                 335     


Ala Ile Ile Lys Glu Asn Lys Glu Leu Phe Phe Thr Asp Asp Glu Leu 
            340                 345                 350         


Asn His Tyr Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu 
        355                 360                 365             


Ser Thr Thr Gly Asn Gly Lys Arg Leu Thr Arg Glu Lys Leu Arg Ile 
    370                 375                 380                 


Gly Tyr Leu Ser Glu Lys Val Trp Lys Asp Cys Leu Asn Thr Met Ser 
385                 390                 395                 400 


Ile Lys Tyr Ile Ala Val Gly Lys Ala Val Tyr His Phe Ala Leu Asp 
                405                 410                 415     


Asp Leu Ala Asp Thr Glu Lys Asp Thr Asp Leu Leu Lys Ile Ala Asp 
            420                 425                 430         


Lys Ala Leu Asp Gly Ile Thr Ser Phe Asp Tyr Glu Glu Ile Lys Ala 
        435                 440                 445             


Asn Glu Thr Leu Gln Arg Glu Val Ala Val Asp Val Ser Phe Ala Ala 
    450                 455                 460                 


Asn Asn Leu Ser Arg Ala Thr Val Lys Thr Ile Lys Gly Lys Glu Asp 
465                 470                 475                 480 


Phe Leu Val Trp Asn Ala Lys Asp Ile Arg Glu Asn Met Arg Tyr Lys 
                485                 490                 495     


Glu Asp Gly Arg Thr Leu Lys Thr Ile Leu Gln Phe Phe Gly Gly Ala 
            500                 505                 510         


Ser Arg Trp Asp Leu Asn Leu Phe Lys Asn Ala Tyr Asn Val Ser Pro 
        515                 520                 525             


Asp Tyr Glu Ile Lys Phe Leu Asp Asp Leu Arg Lys Ile Ile Phe Phe 
    530                 535                 540                 


Leu Arg Asn Glu Ser Phe His Phe Thr Thr Gln Ala Thr Gly Asp Tyr 
545                 550                 555                 560 


Asp Trp Asn Thr Asn Leu Ile Gly Glu Met Phe Ala Glu Asp Ala Asp 
                565                 570                 575     


Val Cys Met Ala Leu Glu Lys Lys Lys Phe Tyr Ser Asn Asn Leu Pro 
            580                 585                 590         


Met Phe Tyr Asn Ser Ser Asp Leu Gln Lys Ile Leu Asp Phe Leu Tyr 
        595                 600                 605             


Lys Glu Asn Pro Ser Arg Ala Ser Gln Val Pro Ser Phe Lys Thr Val 
    610                 615                 620                 


Phe Val Arg Lys Asn Phe Pro Asp Phe Leu Ala Ser His Gly Phe Ser 
625                 630                 635                 640 


Phe Ala Gly Gly Asp Ala Glu Thr Arg Leu Lys Trp Gln Asn Ala Leu 
                645                 650                 655     


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ala Phe Leu Thr Ser Ser 
            660                 665                 670         


Asp Val Lys Asp Asp Phe Phe Lys Ala Leu Asp Gly Leu Pro Ala Glu 
        675                 680                 685             


Asn Glu Asp Ala Leu Asn Asp Phe Arg Arg Arg Cys Arg Asp Phe Lys 
    690                 695                 700                 


Asn Lys Lys Glu Tyr Gly Leu Pro Glu Ile Cys Gln Phe Ile Met Thr 
705                 710                 715                 720 


Glu Tyr Asn Glu Gln Asn Ala Gly Asn Arg Lys Val Arg Ser Ser Lys 
                725                 730                 735     


Ala Asp Gln Met Asn Pro Lys Ile Phe Gln His Tyr Arg Leu Leu Leu 
            740                 745                 750         


Met His Thr Leu Gln Ser Ala Phe Ser Ile Phe Leu Asp Arg Gln Asp 
        755                 760                 765             


Val Leu Lys Val Leu Lys His Ser Gly Arg Lys Arg Glu Leu Met Pro 
    770                 775                 780                 


Glu Glu Glu Phe Leu Asn Ser Trp Ser Ser Thr Met Tyr Lys Asp Thr 
785                 790                 795                 800 


Ile Asn Ala Val Lys Gly Ser Gln Lys Leu Gln Ala Trp Tyr Ile Thr 
                805                 810                 815     


Ala Arg Phe Leu Asn Ala Arg Thr Leu Asn Leu Leu Val Gly Ser Leu 
            820                 825                 830         


Arg Ser Tyr Ile Gln Tyr Ala Arg Asp Val Tyr Arg Arg Ala Gln Glu 
        835                 840                 845             


Thr Glu Asn Gln Val Ile Thr Tyr Glu Glu Asn Thr Val Gln Thr Cys 
    850                 855                 860                 


Glu Lys Val Leu Pro Val Leu Asp Leu Cys Met Lys Leu Ser Ser Val 
865                 870                 875                 880 


Tyr Ser Asn Lys Leu Thr Asp Tyr Phe Phe Asp Asn Glu Glu Tyr Ala 
                885                 890                 895     


Lys Tyr Leu Ser Asn Tyr Val Asn Phe Tyr Asn Ala Gln Val Gly Asp 
            900                 905                 910         


Gly Ser Thr Phe Ala Gln Leu Gln Ala Phe Asp Asp Lys Gly Leu Tyr 
        915                 920                 925             


Met Asp Lys Met Asn Pro Ile Ala Asn Arg Asn Ile Val Met Ala Lys 
    930                 935                 940                 


Leu Phe Gly Pro Val Ser Val Leu Ser Glu Thr Met Ser Pro Val Thr 
945                 950                 955                 960 


Glu Gln Asp Ile Lys Asp Tyr Tyr Asp Lys Arg Glu Glu Ile Ala Gly 
                965                 970                 975     


Tyr Met Val Lys Gly Gln Cys Ser Ser Lys Glu Glu Gln Glu Ser Val 
            980                 985                 990         


Ile Glu Tyr Gln Arg Leu Lys Asn  His Val Glu Leu Arg  Asp Ala Val 
        995                 1000                 1005             


Glu Phe  Gly Glu Ile Ile Asn  Glu Leu Leu Gly Gln  Leu Ile Asn 
    1010                 1015                 1020             


Trp Ser  Tyr Leu Arg Glu Arg  Asp Leu Leu Tyr Phe  Gln Leu Gly 
    1025                 1030                 1035             


Phe His  Tyr Leu Cys Leu Asn  Asn Asp Asp Ala Lys  Lys Pro Glu 
    1040                 1045                 1050             


Gly Tyr  Ile His Ile Thr Arg  Glu Asn Gly Thr Lys  Ile Asn Gly 
    1055                 1060                 1065             


Ala Ile  Leu Ser Gln Val Ala  Gly Met Tyr Ile Asn  Gly Ile Pro 
    1070                 1075                 1080             


Val Phe  Ala Pro Asp Lys Ala  Gly Lys Leu Thr Ala  Gln Ser Ser 
    1085                 1090                 1095             


Lys Gly  Ser Ala Gly Lys Lys  Ile Gly Ser Phe Gly  Ser Tyr Ala 
    1100                 1105                 1110             


Glu Arg  Ile Leu His Glu Asn  Lys Lys Glu Ala Gln  Glu Val Leu 
    1115                 1120                 1125             


Tyr Asn  Ala Gly Leu Glu Leu  Phe Glu Thr Leu Arg  Glu His Asp 
    1130                 1135                 1140             


Asn Val  Val His Val Arg Asn  Ala Ile Asp His Phe  Lys Tyr Tyr 
    1145                 1150                 1155             


Thr Val  Lys Lys Met Asp Asn  Gln Glu Asp Gly Thr  Pro His Ser 
    1160                 1165                 1170             


Ile Leu  Asp Tyr Tyr Ser Glu  Val Phe Asp Arg Phe  Phe Glu Tyr 
    1175                 1180                 1185             


Asp Val  Lys Tyr Gln Lys Thr  Val Val Ser Met Leu  Gln Asn Val 
    1190                 1195                 1200             


Leu Leu  Arg His Phe Val Leu  Phe Phe Pro Ser Phe  Ser Thr Gly 
    1205                 1210                 1215             


Lys Lys  Val Val Gly Ser Ala  Glu Val Lys Asp Arg  Ala Gln Ile 
    1220                 1225                 1230             


Ser Ala  Gln Thr Asn Gly Ile  Ser Ser Asp Thr Leu  Thr Tyr Lys 
    1235                 1240                 1245             


Ile Gln  Asp Cys Ser Asp Leu  Ile Ile Asp Ala Lys  Ser Glu Lys 
    1250                 1255                 1260             


Tyr Arg  Glu Val Ile Gly Lys  Ile Leu Tyr Tyr Pro  Tyr Pro Met 
    1265                 1270                 1275             


Pro Asp  Asp Ile Ile Gly Gly  Glu His Gln Lys Lys  Gly Gly Lys 
    1280                 1285                 1290             


Glu Glu  Asn Ser Arg Arg Lys  Ser Gly Arg Asn Pro  Gly Lys Phe 
    1295                 1300                 1305             


Arg Gln  Gly Lys Lys Glu Arg  Glu Gln Glu Glu Lys  Glu Leu Asn 
    1310                 1315                 1320             


Asn Tyr  Lys Lys Lys Asn Asn  Thr Ala Lys Ser Val  Gly Thr Ser 
    1325                 1330                 1335             


Ile Gly  Asp Ile Leu Asn Gly  Leu Asn Ile Lys 
    1340                 1345                 


<210>  363
<211>  1268
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  363

Met Lys Val Ser Lys Val Asn His Arg Lys Ala Ala Val Ala Val Asn 
1               5                   10                  15      


Lys Lys Ser Val Thr Val Asn Gly Ile Leu Tyr Asp Ala Pro Val Lys 
            20                  25                  30          


Lys Asn Val Lys Thr Gly Asn Met Ser Ala Tyr Val Ser Ser Lys Tyr 
        35                  40                  45              


Val Ile Asp Asn Val Val Lys Asn Ser Ser Arg Leu Tyr Ser Pro Phe 
    50                  55                  60                  


Ser Ser Lys Arg Ile Val Ile Asp Arg Glu Lys Ile Arg Ile Ala Asp 
65                  70                  75                  80  


Arg Leu Lys Gln Cys Tyr Val Asn Phe Val Lys Tyr Tyr Leu Ser Asn 
                85                  90                  95      


Gly Ser Leu Asn Glu Gln Gln Met Arg Phe Asn Pro Asn Asn Thr Tyr 
            100                 105                 110         


Met Thr Asp Ser Arg Val His Phe Cys Ala Pro Ser Gly Ile Asp Lys 
        115                 120                 125             


Glu Ser Leu Ile Asn Ser Ile Val Asp Ser Ser Leu Arg Lys Ser Leu 
    130                 135                 140                 


Lys Arg Thr Tyr Arg Phe Glu Thr Asn Tyr Gly Glu Lys Ile Thr Phe 
145                 150                 155                 160 


Asn Leu Pro Asp Leu Val Lys Lys Ser Ile Lys Ile Tyr Cys Thr Asp 
                165                 170                 175     


Glu Lys Arg Lys Leu Asn Asp Arg Glu Glu Gln Glu Met Tyr Val Leu 
            180                 185                 190         


Phe Ser Tyr Met Tyr Glu Asp Lys Tyr Lys Asp Arg Gln Lys Val Leu 
        195                 200                 205             


Ile Ala Asn Ser Ile Ser Asn Gln Ala Thr Lys Val Lys Val Cys Asp 
    210                 215                 220                 


Asp Glu Ser Ser Leu Ile Lys Leu Ser Ile Ala Asp Thr Lys Lys Lys 
225                 230                 235                 240 


Pro Leu Trp Asp Phe Ile Val Asp Tyr Ala Asn Ser Asp Lys Asn Gly 
                245                 250                 255     


Gln Tyr Thr Ile Leu Arg Asn Ile Arg Lys Ser Ile Val Leu Phe Val 
            260                 265                 270         


Cys Gly Val Asp Val Tyr Arg Asn Ile Glu Asn Asn Asp Asn Leu Asp 
        275                 280                 285             


Ile Trp Lys Trp Glu Glu Tyr Gly Ile Gln Glu Ser Gln Leu Phe Val 
    290                 295                 300                 


Lys Ile Glu Asn Cys Tyr Thr Thr Lys Asp Glu Asp Ile Ala Leu Asn 
305                 310                 315                 320 


Glu Ile Arg Asn Val Asn Leu Asp His Tyr Met Lys Ala Ile Gly Val 
                325                 330                 335     


Leu Asp Asp Glu Arg Ser Lys Phe Trp Phe Gln His Tyr Glu Asn Thr 
            340                 345                 350         


Ile Glu Ala Leu Phe Ser Lys Lys Ser Lys Arg Lys Ile Glu Arg Ile 
        355                 360                 365             


Lys Thr Val Tyr Leu Cys Glu Tyr Leu Trp Lys Asn Phe Cys Ser Tyr 
    370                 375                 380                 


Val Ala Leu Lys Tyr Ile Asp Leu Gly Lys Gly Val Tyr His Phe Thr 
385                 390                 395                 400 


Met Ser Asp Lys Leu Ser Leu Met Asn Lys Asn Thr Asn Glu Asn Gly 
                405                 410                 415     


Ile Lys Phe Gly Glu Val Asp Ser Arg Phe Asn Lys Gly Ile Ser Ser 
            420                 425                 430         


Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Thr Ile Asp Arg Asn Ile 
        435                 440                 445             


Ser Thr Tyr Thr Thr Phe Ala Thr Asn Ile Phe Ala Lys Ser Val Ile 
    450                 455                 460                 


Lys Asp Ser Tyr Ile Gln Lys Lys Ala Gly Asn Ser Asp Ala Leu Gln 
465                 470                 475                 480 


Tyr Asp Gly Glu Thr Tyr Tyr Asn Arg Lys Ala Ile Asn Pro Asp Ala 
                485                 490                 495     


Leu Lys Arg Val Leu Gln Tyr Trp Gly Gly Gln Ser Arg Trp Lys Ser 
            500                 505                 510         


Glu Leu Glu Glu Leu Asn Val Ala Glu Leu Cys Ile Asp Ile Lys Asn 
        515                 520                 525             


Arg Leu Ser Lys Ile Arg Asn Ser Gly Val His Tyr Thr Ser Thr Ser 
    530                 535                 540                 


Ala Leu Lys Gly Asn Asp Asp Asp Ser Ile Val Gly Met Leu Ile Lys 
545                 550                 555                 560 


Lys Asp Phe Asp Asp Ile Lys Asp Val Tyr Ala Ser Lys Tyr Tyr Ser 
                565                 570                 575     


Asn Asn Val Trp Met Phe Tyr Asn Thr Asp Lys Ile Ser Lys Met Met 
            580                 585                 590         


Glu Tyr Leu Tyr Gln Asp Asp Ser Asn Ile Arg Asp Ala Gln Ile Pro 
        595                 600                 605             


Ala Phe Asn Ser Val Ile Lys Arg Lys Asp Met Ala Glu Val Ile Glu 
    610                 615                 620                 


Lys Ile Ile Lys Lys Asn Ser Tyr Lys Thr Ile Lys Glu Pro Tyr Gln 
625                 630                 635                 640 


Arg Glu Lys Tyr Arg Ser Cys Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
                645                 650                 655     


Tyr Asn Arg Phe Ile Lys Gln Asp Asp Leu Lys Asp Gln Val Ile Gln 
            660                 665                 670         


Ile Ile Asp Ser Asn Thr Glu Leu Ile Gly Asp Asn Ser Arg Ala Val 
        675                 680                 685             


Asp Asn Leu Lys Lys Arg Ile His Asp Val Asp Ser Gln Thr Met Ser 
    690                 695                 700                 


Phe Gly Glu Leu Cys Gln Val Ile Met Thr Asp Tyr Asn Met Gln Asn 
705                 710                 715                 720 


Gln Glu Asn Lys Ser Ile Lys Ser Lys Glu Arg Gln Asp Lys Asp Arg 
                725                 730                 735     


Lys Asn Gly Ile Asp Asn Ser Tyr Lys His Phe Pro Leu Leu Leu His 
            740                 745                 750         


His Leu Ile Lys Val Ser Phe Leu Lys Phe Ile Lys Thr Asp Glu Lys 
        755                 760                 765             


Leu Ala Phe Ile Arg Glu Pro Arg Ile Thr Glu Tyr Asp Lys Thr Leu 
    770                 775                 780                 


Glu Gln Phe Glu Ala Gln Ile Gln Thr Val Asp Ile Tyr Asn Ser Leu 
785                 790                 795                 800 


Lys Met Met Val Ala Glu Asn Lys Ser Leu Leu Asp Trp Tyr Thr Leu 
                805                 810                 815     


Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asp Ile 
            820                 825                 830         


Lys Asn Tyr Ile Gln Tyr Leu Ser Asn Ile Asp Lys Arg Ala Gly Ser 
        835                 840                 845             


Val Lys Asn Asn Lys Cys Ala Ser Thr Glu Val Lys Ile Arg Gln Tyr 
    850                 855                 860                 


Ser Glu Ile Val Arg Ile Leu Asp Phe Ser Leu Gln Tyr Ile Gly Arg 
865                 870                 875                 880 


Val Ser Asn Asp Val Thr Asp Tyr Phe Val Asp Glu Asp Glu Tyr Ala 
                885                 890                 895     


Ala Phe Leu Ser Lys Tyr Val Glu Phe Ser Gly Asn Asp Thr Val Ser 
            900                 905                 910         


Met Lys Ala Phe Cys Gln Ser Arg Thr Ala Asn Gly Lys His Thr Ile 
        915                 920                 925             


Gly Leu Tyr Cys Asp Gly Ala Asn Pro Ile Met Asn Arg Asn Ile Ala 
    930                 935                 940                 


Tyr Ala Lys Met Tyr Gly Asn Asp Glu Ile Leu Ser Tyr Ile Tyr Asn 
945                 950                 955                 960 


Lys Val Thr Lys Lys Asp Ile Glu Lys Tyr Tyr Val Ser Gln Asp Asn 
                965                 970                 975     


Leu Glu Lys Val Phe Ala Asp Gly Lys Cys Gln Asp Val Gln Gln Gln 
            980                 985                 990         


Asn Ala Leu Cys Asp Phe Gln Lys  Met Lys Asn His Ile  Glu Leu Thr 
        995                 1000                 1005             


Glu Val  Ser Ile Tyr Thr Asp  Ile Leu Asn Asp Phe  Met Ala Gln 
    1010                 1015                 1020             


Phe Ile  Ser Trp Ala Tyr Leu  Arg Glu Arg Asp Leu  Met Tyr Phe 
    1025                 1030                 1035             


Gln Leu  Gly Leu Asn Tyr Ile  Arg Met Phe Tyr Gly  Thr Tyr Glu 
    1040                 1045                 1050             


Leu Glu  Glu Lys Tyr Asn Lys  Leu His Gly Glu Asn  Ile Asn Ile 
    1055                 1060                 1065             


Glu Lys  Gly Ala Leu Leu Tyr  Gln Ile Val Ala Met  Tyr Ser His 
    1070                 1075                 1080             


Glu Leu  Pro Ile Tyr Lys Val  Asp Glu Ser Asp Ile  Ala Ile Leu 
    1085                 1090                 1095             


Ala Glu  Lys Gln Gly Ser Ser  Gly Ala Ser Ile Lys  Ser Phe Val 
    1100                 1105                 1110             


Thr Glu  Tyr Cys Lys Glu Glu  Met Lys Lys Ala Tyr  Thr Tyr Glu 
    1115                 1120                 1125             


Asn Gly  Leu Glu Phe Phe Glu  Asp Val Asn Gln His  Asp Asn Leu 
    1130                 1135                 1140             


Ser Lys  Leu Arg Asn Asp Phe  Ala His Met Arg Tyr  Met Ser Ala 
    1145                 1150                 1155             


Arg Asp  Lys Ser Ile Met Asp  Ile Val Ser Glu Ile  Tyr Asn Gly 
    1160                 1165                 1170             


Phe Phe  Ile Tyr Asp Thr Lys  Leu Lys Lys Ser Val  Ser Phe Ile 
    1175                 1180                 1185             


Phe Lys  Asn Ile Leu Met Arg  Tyr Ala Val Asp Val  Asn Ile Glu 
    1190                 1195                 1200             


Phe Cys  His Lys Gly Asp Asn  Glu Asp Thr Asn Asn  Leu Ile Arg 
    1205                 1210                 1215             


Ile Lys  Asp Glu Val Gly Leu  Tyr Ser Asp Lys Tyr  Thr Tyr Lys 
    1220                 1225                 1230             


Val Glu  Asp Asn Asp Thr Val  Asp Ile Glu Val Arg  Asn Ser Glu 
    1235                 1240                 1245             


Phe Leu  Glu Gln Leu Lys Lys  Leu Leu Glu Tyr Lys  Lys Glu Ser 
    1250                 1255                 1260             


Lys Gly  Ser Glu Leu 
    1265             


<210>  364
<211>  1425
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  364

Val Ala Leu Gln Leu Tyr Ile Ile Leu Tyr Arg Val Ser Leu Phe Cys 
1               5                   10                  15      


Ala Ile Phe Trp Asp Met Leu Ile Tyr Arg Tyr Asn Ala Ile Phe Asn 
            20                  25                  30          


Pro Gln Gly Cys Gln Lys Ser Lys Lys Cys Thr Arg Val Glu Asp Ser 
        35                  40                  45              


Lys Val Lys Ile Ser Lys Glu Asn His Lys Arg Thr Ala Val Val Val 
    50                  55                  60                  


Lys Lys Asn Arg Val Gly Gly Val Val Tyr Lys Val Pro Gly Gly Ser 
65                  70                  75                  80  


Gly Ile Asp Leu Asn Glu Tyr Leu Ala Lys Arg Ser Arg Asp Ile Lys 
                85                  90                  95      


Ile Leu Tyr Asn Ile Phe Asn Gln Ile Gln Ala Gly Thr Ala Pro Ser 
            100                 105                 110         


Glu Tyr Glu Trp Lys Asp Tyr Leu Ser Glu Ser Glu Asn Lys Arg Arg 
        115                 120                 125             


Glu Ala Gln Lys Thr Ile Gln Lys Ala Asn Tyr Glu Leu Arg Ser Ala 
    130                 135                 140                 


Cys Gly Asp Tyr Ala Lys Lys Ala Asn Ser Val Ile Gly Lys Ile Ile 
145                 150                 155                 160 


Phe Ser Ala Lys Thr Lys Arg Ile Leu Ser Asp Glu Gln Ile Ile Ser 
                165                 170                 175     


Asn Met Lys Ala Gln Arg Leu Tyr Arg Phe Lys Gly Arg Leu Glu Asp 
            180                 185                 190         


Phe Val Leu Leu Thr Leu Arg Lys Ser Leu Ile Val Ser Asn Asn Asn 
        195                 200                 205             


Gly Glu Val Phe Asp Ser Arg Asn Ala Val Thr Val Phe Leu Lys Asn 
    210                 215                 220                 


Ile Gly Lys Glu Asn Ile Ser Glu Asp Asp Glu Arg Glu Ile Lys Arg 
225                 230                 235                 240 


Leu Leu Ala Leu Ile Arg Lys Asp Tyr Asn Lys Trp Asn Pro Gly Gly 
                245                 250                 255     


Gln Ser Ser His Lys Met Tyr Ser Asp Lys Lys Ala Ser Ser Gly Ala 
            260                 265                 270         


Met Val Ile Arg Ser Ile Glu His Gln Asn Met Val Val Gln Pro Lys 
        275                 280                 285             


Glu Asp Arg Leu Arg Leu Ser Glu Ile Ser Ser Val Gly Lys Asn Thr 
    290                 295                 300                 


Lys Thr Lys Gln Thr Glu Lys Ala Gly Leu Glu Ala Phe Leu Thr Glu 
305                 310                 315                 320 


Tyr Ala Gln Ile Asp Ala Asn Ser Arg Met Glu Tyr Leu Lys Lys Leu 
                325                 330                 335     


Arg Arg Leu Leu Asp Thr Tyr Phe Ala Ala Pro Ser Ser Tyr Ile Lys 
            340                 345                 350         


Gly Ala Glu Val Ser Leu Pro Glu Asn Ile Asn Tyr Ser Ser Glu Leu 
        355                 360                 365             


Lys Val Trp Glu Arg His Glu Ala Ala Lys Lys Val Asn Ile Tyr Phe 
    370                 375                 380                 


Val Glu Ile Pro Glu Ala Leu Leu Lys Ala Glu Gln Asn Asn Asn Lys 
385                 390                 395                 400 


Ile Asp Ser Val Glu Lys Glu His Ser Leu Glu Gln Leu Arg Ala Asp 
                405                 410                 415     


Ile Arg Arg Arg Asn Ile Ala Cys Tyr His Phe Thr Asn Ala Leu Ala 
            420                 425                 430         


Ala Asp Lys Arg Tyr Pro Thr Leu Phe Phe Glu Asn Met Ala Met Asn 
        435                 440                 445             


Gln Tyr Trp Ile His His Met Glu Asn Ala Val Glu Arg Ile Leu Lys 
    450                 455                 460                 


Lys Cys Asn Val Gly Thr Leu Phe Lys Leu Lys Ile Gly Tyr Leu Ser 
465                 470                 475                 480 


Glu Lys Val Trp Lys Asp Val Leu Asn Leu Leu Ser Ile Lys Tyr Ile 
                485                 490                 495     


Ala Leu Gly Lys Ala Val Tyr His Phe Ala Leu Asp Asp Ile Trp Asn 
            500                 505                 510         


Glu Ala Ser Val Lys Lys Leu Gly Lys Met Asn Ala His Thr Leu Glu 
        515                 520                 525             


Gly Ile Ser Ser Phe Asp Tyr Glu Met Val Lys Ala Gln Glu Asp Leu 
    530                 535                 540                 


Gln Arg Glu Met Ala Val Gly Val Ala Phe Ser Ala Asn Asn Leu Ala 
545                 550                 555                 560 


Arg Ala Thr Cys Gln Met Asn Asn Leu Ala Asp Lys Glu Ser Asp Phe 
                565                 570                 575     


Leu Leu Trp Asp Asp Asn Lys Val Ile Ala Lys His Ile Lys Tyr Thr 
            580                 585                 590         


Glu Lys Gly Lys Thr Leu Ser Ala Ile Leu Gln Phe Phe Gly Gly Arg 
        595                 600                 605             


Ser Ser Trp Asp Thr Ser Leu Phe Glu Asn Ala Tyr Ser Asp Ser Asn 
    610                 615                 620                 


Tyr Glu Leu Gln Phe Leu Asn Asp Leu Arg Arg Ala Ile Tyr Ala Ala 
625                 630                 635                 640 


Arg Asn Glu Thr Phe His Phe Lys Thr Ala Ala Ile Asp Glu Gly Ser 
                645                 650                 655     


Trp Asn Thr Arg Leu Phe Gly Asn Met Phe Glu Lys Glu Ala Glu Ile 
            660                 665                 670         


Cys Leu Ser Val Glu Lys Asn Lys Phe Tyr Ser Asn Asn Leu Ala Leu 
        675                 680                 685             


Phe Tyr Thr Gln Lys Asp Leu Lys Val Ile Leu Asp Arg Leu Tyr Gly 
    690                 695                 700                 


Lys Glu Tyr Ser Arg Ala Ala Gln Ile Pro Ser Tyr Asn Thr Ile Leu 
705                 710                 715                 720 


Ser Arg Lys Ser Phe Pro Asp Phe Leu Lys Gln Leu Leu Lys Leu Gln 
                725                 730                 735     


Gly Pro Val Tyr Asp Leu Ala Val Arg Asp Gln Trp Tyr Ser Ala Cys 
            740                 745                 750         


Tyr Tyr Leu Phe Lys Glu Val Tyr Tyr Asn Leu Phe Leu Gln Asp Val 
        755                 760                 765             


Ser Ala Lys Glu Leu Phe Glu Asp Ala Val Lys Glu Leu Glu Gly Ala 
    770                 775                 780                 


Asp Glu Lys Gln Lys Arg Ala Val Glu Asn Phe Lys Lys Arg Tyr Arg 
785                 790                 795                 800 


Glu Ile Ser Ile Ser Ala Ser Leu Ala Asp Ile Cys Gln Ser Phe Met 
                805                 810                 815     


Thr Glu Tyr Ser Gln Gln Asn Asn Lys Asp Arg Lys Val Arg Ser Ala 
            820                 825                 830         


Asn Asp Gly Ile Phe Asn Glu Pro Ile Tyr Gln His Tyr Lys Met Leu 
        835                 840                 845             


Leu Arg Glu Ser Leu Lys Val Ala Phe Ala Ser Tyr Ile Lys Asn Asn 
    850                 855                 860                 


Lys Glu Leu Glu Phe Val Phe Asn Pro Thr Lys Lys Pro Phe Glu Val 
865                 870                 875                 880 


Ser Gln Asp Arg Phe Leu Pro Asp Trp Ser Ser Glu Lys Tyr Asp Thr 
                885                 890                 895     


Leu Ile Ser Glu Val Lys Asn Ser Pro Glu Leu Gln Lys Trp Tyr Ile 
            900                 905                 910         


Val Gly Lys Phe Met Asn Ala Arg Met Leu Asn Leu Thr Ile Gly Ser 
        915                 920                 925             


Met Arg Ser Tyr Leu Gln Tyr Val Asn Asp Ile Gln Lys Arg Ala Ala 
    930                 935                 940                 


Ser Leu Gly Glu Arg Gln Leu His Leu Phe Val Gly Asn Val Glu Gln 
945                 950                 955                 960 


Val Lys Lys Trp Ile Gln Val Leu Glu Cys Cys Leu Leu Leu Ser Val 
                965                 970                 975     


Arg Ile Ser Asn Glu Phe Lys Asp Tyr Phe Ile Asn Glu Asp Ala Tyr 
            980                 985                 990         


Ala Ser Tyr Leu Lys Gly Tyr Val  Asp Phe Glu Asp Ser  Val Met Pro 
        995                 1000                 1005             


Ser Asp  Tyr Ser Ala Leu Leu  Ala Phe Ser Asp Glu  Gly Lys Ile 
    1010                 1015                 1020             


Asp Leu  Tyr Val Asp Ala Ser  Asn Pro Lys Val Asn  Arg Asn Ile 
    1025                 1030                 1035             


Ile Gln  Ala Lys Leu Tyr Ala  Pro Asp Leu Val Leu  Lys Lys Val 
    1040                 1045                 1050             


Val Lys  Lys Ile Ser Lys Asp  Glu Cys Lys Glu Phe  Tyr Glu Lys 
    1055                 1060                 1065             


Lys Glu  Gln Ile Leu Gln Ile  Lys Asn Lys Gly Asp  Glu Val Ser 
    1070                 1075                 1080             


Trp Glu  Glu Gln Gln Lys Ile  Leu Glu Tyr Gln Lys  Leu Lys Asn 
    1085                 1090                 1095             


Arg Val  Glu Leu Arg Asn Leu  Ala Glu Tyr Gly Glu  Leu Ile Asn 
    1100                 1105                 1110             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Tyr Leu  Arg Glu Arg 
    1115                 1120                 1125             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Ser  Cys Leu Met 
    1130                 1135                 1140             


Asn Glu  Ser Lys Lys Pro Asp  Ala Tyr Lys Thr Ile  Cys Ile Asp 
    1145                 1150                 1155             


Asp Ala  Val Ser Ile Glu Asn  Ala Val Leu Tyr Gln  Ile Ile Ala 
    1160                 1165                 1170             


Met Tyr  Ile Asn Gly Phe Pro  Val Tyr Val Pro Lys  Lys Gly Lys 
    1175                 1180                 1185             


Leu Lys  Ala Glu Cys Lys Ile  Ser Gly Gly Gly Ile  Lys Val Pro 
    1190                 1195                 1200             


Ala Phe  Cys Arg Trp Ala Ser  Thr Ile Glu Glu Lys  Lys Leu Glu 
    1205                 1210                 1215             


Leu Tyr  Cys Ala Gly Leu Glu  Leu Phe Glu Val Val  Ser Glu His 
    1220                 1225                 1230             


Gly Asn  Val Ile Asp Leu Arg  Asn Lys Ile Asp His  Phe Lys Tyr 
    1235                 1240                 1245             


Tyr Gln  Gly Asn Asp Ser Ile  Leu Ser Leu Tyr Gly  Glu Ile Phe 
    1250                 1255                 1260             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Arg Lys  Asn Val Leu 
    1265                 1270                 1275             


Asn His  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Val Ile Lys 
    1280                 1285                 1290             


Pro Val  Ile Gly Lys Asp Ile  Lys Lys Val Gly Lys  Glu Glu Thr 
    1295                 1300                 1305             


Lys Asp  Arg Ala Ala Phe Leu  Leu Glu Glu Val Ser  Ser Asp Arg 
    1310                 1315                 1320             


Phe Thr  Tyr Lys Val Lys Glu  Gly Glu Arg Lys Ile  Asp Ala Lys 
    1325                 1330                 1335             


Asn Arg  Leu Tyr Leu Glu Thr  Val Arg Asp Ile Leu  Tyr Phe Pro 
    1340                 1345                 1350             


Asn Arg  Ala Val Asn Asp Lys  Gly Glu Asp Val Ile  Ile Cys Ser 
    1355                 1360                 1365             


Gln Lys  Ala Gln Asp Leu Asp  Glu Glu Lys Thr Asp  Arg Asp Lys 
    1370                 1375                 1380             


Lys His  Asp Lys Arg Lys Asn  Gly Ser Trp Lys Lys  Asn Gly Asp 
    1385                 1390                 1395             


Asn Gln  Gly Glu Lys Ser Lys  Leu Glu Glu Ala Tyr  Ser Asn Arg 
    1400                 1405                 1410             


Ile Thr  Trp Asn Pro Phe Ala  Gly Thr Lys Leu Asp  
    1415                 1420                 1425 


<210>  365
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  365

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Asp Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His 
            180                 185                 190         


Glu Arg Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Lys Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asp 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  366
<211>  1315
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  366

Met Ala Glu Thr Leu Thr Phe Thr Asn Leu Tyr Asp Ile Leu Thr Leu 
1               5                   10                  15      


Ile Asp Ser Gly Leu Asn Leu His Ile Asn Leu Gly Val Ile Ile Met 
            20                  25                  30          


Lys Leu Thr Arg Arg Arg Ile Ser Gly Asn Ser Val Asp Gln Lys Ile 
        35                  40                  45              


Thr Ala Ala Phe Tyr Arg Asp Met Ser Gln Gly Leu Leu Tyr Tyr Asp 
    50                  55                  60                  


Ser Glu Asp Asn Asp Cys Thr Asp Lys Val Ile Glu Ser Met Asp Phe 
65                  70                  75                  80  


Glu Arg Ser Trp Arg Gly Arg Ile Leu Lys Asn Gly Glu Asp Asp Lys 
                85                  90                  95      


Asn Pro Phe Tyr Met Phe Val Lys Gly Leu Val Gly Ser Asn Asp Lys 
            100                 105                 110         


Ile Val Cys Glu Pro Ile Asp Val Asp Ser Asp Pro Asp Asn Leu Asp 
        115                 120                 125             


Ile Leu Ile Asn Lys Asn Leu Thr Gly Phe Gly Arg Asn Leu Lys Ala 
    130                 135                 140                 


Pro Asp Ser Asn Asp Thr Leu Glu Asn Leu Ile Arg Lys Ile Gln Ala 
145                 150                 155                 160 


Gly Ile Pro Glu Glu Glu Val Leu Pro Glu Leu Lys Lys Ile Lys Glu 
                165                 170                 175     


Met Ile Gln Lys Asp Ile Val Asn Arg Lys Glu Gln Leu Leu Lys Ser 
            180                 185                 190         


Ile Lys Asn Asn Arg Ile Pro Phe Ser Leu Glu Gly Ser Lys Leu Val 
        195                 200                 205             


Pro Ser Thr Lys Lys Met Lys Trp Leu Phe Lys Leu Ile Asp Val Pro 
    210                 215                 220                 


Asn Lys Thr Phe Asn Glu Lys Met Leu Glu Lys Tyr Trp Glu Ile Tyr 
225                 230                 235                 240 


Asp Tyr Asp Lys Leu Glu Ala Asn Ile Thr Asn Arg Leu Asp Lys Thr 
                245                 250                 255     


Asp Lys Asn Ala Arg Ser Ile Ser Arg Ala Val Ser Asp Glu Leu Arg 
            260                 265                 270         


Glu Tyr His Lys Tyr Leu Arg Thr Asn Tyr Asn Arg Phe Val Ser Gly 
        275                 280                 285             


Asp Arg Pro Ala Ala Gly Leu Asp Asn Gly Gly Ser Ala Lys Tyr Asn 
    290                 295                 300                 


Pro Asp Lys Glu Glu Phe Leu Leu Phe Leu Lys Glu Val Glu Gln Tyr 
305                 310                 315                 320 


Phe Lys Lys Tyr Phe Pro Val Lys Ser Lys His Ser Asn Lys Ser Lys 
                325                 330                 335     


Asp Lys Ser Leu Val Asp Lys Tyr Lys Asn Tyr Cys Ser Tyr Lys Val 
            340                 345                 350         


Val Lys Lys Glu Val Asn Arg Ser Ile Ile Asn Gln Leu Val Ala Gly 
        355                 360                 365             


Leu Ile Gln Gln Gly Lys Leu Leu Tyr Tyr Phe Tyr Tyr Asn Asp Thr 
    370                 375                 380                 


Trp Gln Glu Asp Phe Leu Asn Ser Tyr Gly Leu Ser Tyr Ile Gln Val 
385                 390                 395                 400 


Glu Glu Ala Phe Lys Lys Ser Val Met Thr Ser Leu Ser Trp Gly Ile 
                405                 410                 415     


Asn Arg Leu Thr Ser Phe Phe Ile Asp Asp Ser Asn Thr Val Lys Phe 
            420                 425                 430         


Asp Asp Ile Thr Thr Lys Arg Ala Lys Glu Ala Ile Glu Ser Asn Tyr 
        435                 440                 445             


Phe Asn Lys Leu Arg Thr Cys Ser Arg Met Gln Asp His Phe Lys Glu 
    450                 455                 460                 


Lys Leu Ala Phe Phe Tyr Pro Val Tyr Val Lys Asp Lys Lys Asp Arg 
465                 470                 475                 480 


Pro Asp Asp Ile Glu Lys Leu Ile Val Leu Val Lys Asn Ala Ile Glu 
                485                 490                 495     


Ser Val Ser Tyr Leu Arg Asn Arg Ile Phe His Phe Lys Lys Ser Ser 
            500                 505                 510         


Leu Leu Glu Leu Leu Lys Glu Leu Asp Asp Lys Asn Ser Gly Gln Asp 
        515                 520                 525             


Lys Ile Asp Tyr Ser Val Ala Ala Glu Phe Ile Lys Arg Asp Ile Glu 
    530                 535                 540                 


Asn Leu Tyr Asp Val Phe Arg Glu Gln Ile Arg Ser Leu Gly Ile Ala 
545                 550                 555                 560 


Glu Tyr Tyr Lys Ala Asp Met Ile Ser Asp Cys Phe Lys Thr Cys Gly 
                565                 570                 575     


Leu Glu Phe Ala Leu Tyr Ser Pro Lys Asn Ser Leu Met Pro Ala Phe 
            580                 585                 590         


Lys Asn Val Tyr Lys Arg Gly Ala Asn Leu Asn Lys Ala Tyr Ile Arg 
        595                 600                 605             


Asp Lys Gly Pro Lys Glu Thr Gly Asp Gln Gly Gln Asn Ser Tyr Lys 
    610                 615                 620                 


Ala Leu Glu Glu Tyr Arg Glu Leu Thr Trp Tyr Ile Glu Val Lys Asn 
625                 630                 635                 640 


Asn Asp Gln Ser Tyr Asn Ala Tyr Lys Asn Leu Leu Gln Leu Ile Tyr 
                645                 650                 655     


Tyr His Ala Phe Leu Pro Glu Val Arg Glu Asn Glu Ala Leu Ile Thr 
            660                 665                 670         


Asp Phe Ile Asn Arg Thr Lys Glu Trp Asn Arg Lys Glu Thr Glu Glu 
        675                 680                 685             


Arg Leu Asn Thr Lys Asn Asn Lys Lys His Lys Asn Phe Asp Glu Asn 
    690                 695                 700                 


Asp Asp Ile Thr Val Asn Thr Tyr Arg Tyr Glu Ser Ile Pro Asp Tyr 
705                 710                 715                 720 


Gln Gly Glu Ser Leu Asp Asp Tyr Leu Lys Val Leu Gln Arg Lys Gln 
                725                 730                 735     


Met Ala Arg Ala Lys Glu Val Asn Glu Lys Glu Glu Gly Asn Asn Asn 
            740                 745                 750         


Tyr Ile Gln Phe Ile Arg Asp Val Val Val Trp Ala Phe Gly Ala Tyr 
        755                 760                 765             


Leu Glu Asn Lys Leu Lys Asn Tyr Lys Asn Glu Leu Gln Pro Pro Leu 
    770                 775                 780                 


Ser Lys Glu Asn Ile Gly Leu Asn Asp Thr Leu Lys Glu Leu Phe Pro 
785                 790                 795                 800 


Glu Glu Lys Val Lys Ser Pro Phe Asn Ile Lys Cys Arg Phe Ser Ile 
                805                 810                 815     


Ser Thr Phe Ile Asp Asn Lys Gly Lys Ser Thr Asp Asn Thr Ser Ala 
            820                 825                 830         


Glu Ala Val Lys Thr Asp Gly Lys Glu Asp Glu Lys Asp Lys Lys Asn 
        835                 840                 845             


Ile Lys Arg Lys Asp Leu Leu Cys Phe Tyr Leu Phe Leu Arg Leu Leu 
    850                 855                 860                 


Asp Glu Asn Glu Ile Cys Lys Leu Gln His Gln Phe Ile Lys Tyr Arg 
865                 870                 875                 880 


Cys Ser Leu Lys Glu Arg Arg Phe Pro Gly Asn Arg Thr Glu Leu Glu 
                885                 890                 895     


Lys Glu Thr Glu Leu Leu Ala Glu Leu Glu Glu Leu Met Glu Leu Val 
            900                 905                 910         


Arg Phe Thr Met Pro Ser Ile Pro Glu Ile Ser Ala Lys Ala Glu Ser 
        915                 920                 925             


Gly Tyr Asp Thr Met Ile Lys Lys Tyr Phe Lys Asp Phe Ile Glu Lys 
    930                 935                 940                 


Lys Val Phe Lys Asn Pro Lys Thr Ser Asn Leu Tyr Tyr His Ser Asp 
945                 950                 955                 960 


Ser Lys Thr Pro Val Thr Arg Lys Tyr Met Ala Leu Leu Met Arg Ser 
                965                 970                 975     


Ala Pro Leu His Leu Tyr Lys Asp Ile Phe Lys Gly Tyr Tyr Leu Ile 
            980                 985                 990         


Thr Lys Lys Glu Cys Leu Glu Tyr  Ile Lys Leu Ser Asn  Ile Ile Lys 
        995                 1000                 1005             


Asp Tyr  Gln Asn Ser Leu Asn  Glu Leu His Glu Gln  Leu Glu Arg 
    1010                 1015                 1020             


Ile Lys  Leu Lys Ser Glu Lys  Gln Asn Gly Lys Asp  Ser Leu Tyr 
    1025                 1030                 1035             


Leu Asp  Lys Lys Asp Phe Tyr  Lys Val Lys Glu Tyr  Val Glu Asn 
    1040                 1045                 1050             


Leu Glu  Gln Val Ala Arg Tyr  Lys His Leu Gln His  Lys Ile Asn 
    1055                 1060                 1065             


Phe Glu  Thr Leu Tyr Arg Ile  Phe Arg Ile His Val  Asp Ile Ala 
    1070                 1075                 1080             


Ala Arg  Met Val Gly Tyr Thr  Gln Asp Trp Glu Arg  Asp Met His 
    1085                 1090                 1095             


Phe Leu  Phe Lys Ala Leu Val  Tyr Asn Gly Val Leu  Glu Glu Arg 
    1100                 1105                 1110             


Arg Phe  Glu Ala Ile Phe Asn  Asn Asn Asp Asp Asn  Asn Asp Gly 
    1115                 1120                 1125             


Arg Ile  Val Lys Lys Ile Gln  Asn Asn Leu Asn Asn  Lys Asn Arg 
    1130                 1135                 1140             


Glu Leu  Val Ser Met Leu Cys  Trp Asn Lys Lys Leu  Asn Lys Asn 
    1145                 1150                 1155             


Glu Phe  Gly Ala Ile Ile Trp  Lys Arg Asn Pro Ile  Ala His Leu 
    1160                 1165                 1170             


Asn His  Phe Thr Gln Thr Glu  Gln Asn Ser Lys Ser  Ser Leu Glu 
    1175                 1180                 1185             


Ser Leu  Ile Asn Ser Leu Arg  Ile Leu Leu Ala Tyr  Asp Arg Lys 
    1190                 1195                 1200             


Arg Gln  Asn Ala Val Thr Lys  Thr Ile Asn Asp Leu  Leu Leu Asn 
    1205                 1210                 1215             


Asp Tyr  His Ile Arg Ile Lys  Trp Glu Gly Arg Val  Asp Glu Gly 
    1220                 1225                 1230             


Gln Ile  Tyr Phe Asn Ile Lys  Glu Lys Glu Asp Ile  Glu Asn Glu 
    1235                 1240                 1245             


Pro Ile  Ile His Leu Lys His  Leu His Lys Lys Asp  Cys Tyr Ile 
    1250                 1255                 1260             


Tyr Lys  Asn Ser Tyr Met Phe  Asp Lys Gln Lys Glu  Trp Ile Cys 
    1265                 1270                 1275             


Asn Gly  Ile Lys Glu Glu Val  Tyr Asp Lys Ser Ile  Leu Lys Cys 
    1280                 1285                 1290             


Ile Gly  Asn Leu Phe Lys Phe  Asp Tyr Glu Asp Lys  Asn Lys Ser 
    1295                 1300                 1305             


Ser Ala  Asn Pro Lys His Thr  
    1310                 1315 


<210>  367
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  367

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Ile Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Phe Asp Phe Lys Leu  Leu Asn 
    1400                 1405                 1410         


<210>  368
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  368

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Ile Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Tyr Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Phe Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Phe Asp Phe Lys Leu  Leu Asn 
    1400                 1405                 1410         


<210>  369
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  369

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Ile Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Phe Asp Phe Lys Leu  Leu Asn 
    1400                 1405                 1410         


<210>  370
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  370

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Ile Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Phe Asp Phe Lys Leu  Leu Asn 
    1400                 1405                 1410         


<210>  371
<211>  1284
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  371

Met Arg Met Lys Ile Ser Lys Val Asp His Val Lys Ser Gly Ile Asp 
1               5                   10                  15      


Gln Lys Leu Ser Asn Gln Arg Gly Met Leu Tyr Lys Gln Pro Gln Lys 
            20                  25                  30          


Lys Tyr Glu Gly Lys Gln Leu Glu Glu His Val Arg Asn Leu Asn Arg 
        35                  40                  45              


Lys Ala Lys Ala Leu Tyr Gln Val Phe Pro Ala Ser Gly Asn Pro Lys 
    50                  55                  60                  


Thr Glu Lys Glu Leu Gln Ile Ile Asn Ser Phe Ile Lys Asn Ile Leu 
65                  70                  75                  80  


Ile Arg Leu Asp Ser Gly Lys Thr Ser Glu Glu Ile Val Gly Tyr Ile 
                85                  90                  95      


Asn Thr Tyr Ser Val Ala Gly Gln Ile Ser Gly Asp His Ile Gln Glu 
            100                 105                 110         


Leu Val Asp Gln His Leu Lys Glu Ser Leu Arg Lys Tyr Thr Cys Val 
        115                 120                 125             


Asp Asp Lys Arg Ile Tyr Val Pro Asp Ile Ile Val Ala Leu Leu Lys 
    130                 135                 140                 


Ser Lys Phe Asn Ser Glu Thr Leu Gln Tyr Asp Asn Ser Glu Leu Lys 
145                 150                 155                 160 


Ile Leu Ile Asp Phe Ile Arg Glu Asp Tyr Leu Lys Glu Lys Gln Ile 
                165                 170                 175     


Lys Gln Ile Val His Ser Ile Glu Asn Asn Ser Thr Pro Leu Arg Ile 
            180                 185                 190         


Ala Glu Ile Asn Gly Gln Lys Arg Leu Ile Pro Ala Asn Ala Asp Asn 
        195                 200                 205             


Pro Lys Lys Ser Tyr Ile Phe Glu Phe Leu Lys Glu Tyr Ala Gln Ser 
    210                 215                 220                 


Asp Pro Lys Gly Gln Glu Ser Leu Leu Gln His Met Arg Tyr Leu Ile 
225                 230                 235                 240 


Leu Leu Tyr Leu Tyr Gly Ser Asp Lys Ile Thr Asp Asp Tyr Cys Glu 
                245                 250                 255     


Glu Ile Gly Ala Trp Asn Phe Gly Ser Ile Val Met Asp Asn Glu Gln 
            260                 265                 270         


Leu Phe Ser Glu Glu Ala Ser Met Leu Ile Gln Asp Arg Ile Tyr Val 
        275                 280                 285             


Asn Gln Gln Ile Gln Glu Gly Arg Gln Ser Lys Asp Thr Ala Lys Val 
    290                 295                 300                 


Lys Lys Asn Lys Ser Lys Tyr Arg Met Leu Gly Asp Lys Ile Glu His 
305                 310                 315                 320 


Ser Ile Asn Glu Ser Val Val Lys His Tyr Gln Glu Ala Cys Lys Ala 
                325                 330                 335     


Val Glu Glu Lys Asp Ile Pro Trp Ile Lys Tyr Ile Ser Asp His Val 
            340                 345                 350         


Met Ser Val Tyr Ser Ser Lys Asn Arg Val Asp Leu Asp Lys Leu Ser 
        355                 360                 365             


Leu Pro Tyr Leu Ala Lys Asn Thr Trp Asn Thr Trp Ile Ser Phe Ile 
    370                 375                 380                 


Ala Met Lys Tyr Val Asp Met Gly Lys Gly Val Tyr His Phe Ala Met 
385                 390                 395                 400 


Ser Asp Val Asp Lys Val Gly Lys Gln Asp Asn Leu Ile Ile Gly Gln 
                405                 410                 415     


Ile Asp Pro Lys Phe Ala Asp Gly Ile Ser Ser Phe Asp Tyr Glu Arg 
            420                 425                 430         


Ile Lys Ala Glu Asp Asp Leu His Arg Ser Met Ser Gly Tyr Ile Ala 
        435                 440                 445             


Phe Ala Val Asn Asn Phe Ser Arg Ala Ile Cys Ser Asp Glu Phe Arg 
    450                 455                 460                 


Lys Lys Asp Lys Lys Glu Asp Val Leu Thr Val Gly Leu Asp Glu Ile 
465                 470                 475                 480 


Pro Leu Asp Asp Asn Val Lys Arg Lys Leu Leu Gln Tyr Phe Gly Gly 
                485                 490                 495     


Ala Ser Asn Trp Asp Asp Ser Ile Met Asp Ile Ile Asp Asp Lys Asp 
            500                 505                 510         


Leu Ala Ala Cys Ile Lys Glu Asn Leu Tyr Val Ala Arg Asn Val Asn 
        515                 520                 525             


Phe His Phe Ala Gly Ser Glu Lys Val Gln Lys Lys Gln Asp Asp Ile 
    530                 535                 540                 


Leu Glu Glu Ile Val Arg Lys Glu Thr Gly Asp Ile Gly Lys His Tyr 
545                 550                 555                 560 


Arg Lys Val Phe Tyr Ser Asn Asn Val Ala Ala Phe Tyr Arg Asp Glu 
                565                 570                 575     


Asp Ile Ile Lys Leu Met Asn His Leu Tyr Gln Lys Glu Lys Pro Tyr 
            580                 585                 590         


Gln Ala Gln Ile Pro Ser Tyr Asn Lys Val Ile Ser Lys Thr Tyr Leu 
        595                 600                 605             


Pro Asp Leu Ile Phe Met Leu Leu Lys Gly Lys Asn Arg Thr Lys Ile 
    610                 615                 620                 


Ser Asp Pro Ser Ile Met Asn Met Phe Arg Gly Thr Phe Tyr Phe Leu 
625                 630                 635                 640 


Leu Lys Glu Ile Tyr Tyr Asn Asp Phe Leu Gln Ala Ser Asn Leu Lys 
                645                 650                 655     


Glu Leu Phe Arg Glu Gly Leu Lys Asn Asn Val Lys Asp Lys Lys Ser 
            660                 665                 670         


Glu Lys Ala Tyr Gln Asn Phe Met Gln Arg Phe Glu Glu Leu Glu Asn 
        675                 680                 685             


Met Gly Met Asp Phe Gly Glu Ile Cys Gln Gln Ile Met Thr Asp Tyr 
    690                 695                 700                 


Glu Gln Gln Asn Lys Gln Lys Lys Lys Thr Ala Thr Ala Val Val Ser 
705                 710                 715                 720 


Glu Lys Asp Lys Lys Ile Arg Thr Leu Asp Asn Asp Thr Gln Lys Tyr 
                725                 730                 735     


Lys His Phe Arg Thr Leu Leu Tyr Val Gly Leu Arg Glu Ala Phe Ile 
            740                 745                 750         


Ile Tyr Leu Lys Asp Glu Lys Asn Lys Glu Trp Tyr Glu Phe Leu Arg 
        755                 760                 765             


Glu Pro Val Lys Arg Glu Gln Pro Glu Glu Lys Glu Phe Val Asn Lys 
    770                 775                 780                 


Trp Lys Leu Asn Gln Tyr Ser Asp Cys Ser Glu Leu Ile Leu Lys Asp 
785                 790                 795                 800 


Pro Leu Ala Ala Ala Trp Tyr Val Ala Ala His Phe Ile Asn Gln Ala 
                805                 810                 815     


Gln Leu Asn His Leu Ile Gly Asp Ile Lys Asn Tyr Ile Gln Phe Ile 
            820                 825                 830         


Ser Asp Ile Asp Arg Arg Ala Lys Ser Thr Gly Asn Pro Val Ser Glu 
        835                 840                 845             


Ser Thr Glu Ile Gln Ile Asp Arg Tyr Arg Gln Ile Leu Arg Val Leu 
    850                 855                 860                 


Glu Phe Ala Lys Phe Phe Cys Gly Gln Ile Thr Asn Val Leu Thr Asp 
865                 870                 875                 880 


Tyr Tyr Glu Asp Glu Asn Asp Phe Ser Thr His Val Gly His Tyr Val 
                885                 890                 895     


Lys Phe Glu Lys Lys Asn Met Glu Pro Ala His Ala Leu Gln Ala Phe 
            900                 905                 910         


Ser Asn Ser Leu Tyr Ala Cys Gly Lys Glu Lys Lys Lys Ala Gly Phe 
        915                 920                 925             


Tyr Tyr Asp Gly Met Asn Pro Ile Val Asn Arg Asn Ile Thr Leu Ala 
    930                 935                 940                 


Ala Met Tyr Gly Asn Lys Lys Leu Leu Glu Asn Ala Met Ile Pro Val 
945                 950                 955                 960 


Thr Glu Gln Asp Ile Arg Lys Tyr Tyr Ser Leu Met Ala Glu Leu Asp 
                965                 970                 975     


Ser Thr Leu Lys Asn Gly Ala Val Cys Lys Ser Glu Asp Glu Gln Lys 
            980                 985                 990         


Asn Leu Arg His Phe Gln Asn Leu  Lys Asn Arg Ile Glu  Leu Val Asp 
        995                 1000                 1005             


Val Leu  Thr Leu Ser Glu Leu  Leu Asn Asp Leu Val  Ala Gln Leu 
    1010                 1015                 1020             


Ile Gly  Trp Ala Tyr Ile Arg  Glu Arg Asp Met Met  Tyr Leu Gln 
    1025                 1030                 1035             


Leu Gly  Leu His Tyr Ile Lys  Leu Tyr Phe Thr Asp  Ser Val Ser 
    1040                 1045                 1050             


Glu Asp  Ser Tyr Leu Arg Thr  Leu Asp Leu Glu Glu  Gly Ser Ile 
    1055                 1060                 1065             


Ala Asp  Gly Ala Val Leu Tyr  Gln Ile Ala Ser Leu  Tyr Ser Phe 
    1070                 1075                 1080             


Asn Leu  Pro Met Tyr Val Lys  Pro Asn Glu Ser Ser  Val Tyr Cys 
    1085                 1090                 1095             


Lys Lys  His Ala Asn Ser Val  Gly Ala Lys Phe Asp  Ile Phe Glu 
    1100                 1105                 1110             


Lys Lys  Tyr Cys Asn Arg Asp  Gly Thr Val Ile Glu  Asn Gly Leu 
    1115                 1120                 1125             


Cys Leu  Phe Glu Asn Ile Lys  Leu His Gly Asp Leu  Ala Glu Phe 
    1130                 1135                 1140             


Arg Asp  Tyr Leu Ala His Phe  Lys Tyr Phe Ala Lys  Leu Asp Lys 
    1145                 1150                 1155             


Ser Ile  Leu Glu Leu Tyr Ser  Lys Val Tyr Asp Ser  Phe Phe Ser 
    1160                 1165                 1170             


Tyr Asn  Ile Lys Leu Lys Lys  Ser Val Ser Tyr Val  Phe Thr Asn 
    1175                 1180                 1185             


Ile Leu  Leu Ser Tyr Phe Ile  Asn Ala Lys Leu Ser  Phe Ser Leu 
    1190                 1195                 1200             


Cys Gly  Ile Ser Asp Tyr Lys  Pro Ser Arg Asn Lys  Thr Val Gln 
    1205                 1210                 1215             


Arg Arg  Ser Ala Asn Ile Ser  Val Glu Ser Val Gln  Thr Asp Tyr 
    1220                 1225                 1230             


Phe Thr  Tyr Lys Leu Arg Ser  Ile Val Lys Asn Lys  Asn Gly Val 
    1235                 1240                 1245             


Glu Ser  Ile Glu Asn Asp Asn  Arg Arg Cys Glu Val  Val Asn Ile 
    1250                 1255                 1260             


Ala Ala  Arg Asp Lys Glu Phe  Val Asp Glu Val Cys  Lys Val Ile 
    1265                 1270                 1275             


Lys Tyr  Asn Ser Asp Lys 
    1280                 


<210>  372
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  372

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Ile Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Phe Asp Phe Lys Leu  Leu Asn 
    1400                 1405                 1410         


<210>  373
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  373

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Asp Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Thr 
        115                 120                 125             


Lys Asp Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His 
            180                 185                 190         


Glu Arg Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Glu Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Arg 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Lys 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Thr Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Phe Asp Phe Lys Leu  Leu Asn 
    1370                 1375                 1380         


<210>  374
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  374

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Leu Tyr Gln Ile Val  Ser Ala Phe Asn Phe  Gly Ser Lys 
    1205                 1210                 1215             


Leu Leu  Tyr Ile Ser Glu Asp  Gly Arg Trp Lys Met  Ala Gly Gly 
    1220                 1225                 1230             


Ala Phe  Pro Gly Lys Tyr Gly  Arg Phe Glu Asn Asp  Tyr Asn His 
    1235                 1240                 1245             


Arg Thr  Ser Leu Ser Lys Val  Ile Arg Leu Phe Glu  Asn Glu Ser 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ile Ile Tyr  Trp Arg Asp Tyr Val  Asp His Met 
    1265                 1270                 1275             


Lys Tyr  Tyr Val Asn Gln Asn  Gln Ser Ile Met Glu  Ile Tyr Ser 
    1280                 1285                 1290             


Ala Phe  Tyr Ser Lys Val Leu  Gly Tyr Ser Ala Lys  Leu Arg Lys 
    1295                 1300                 1305             


Ser Val  Val Phe Asn Leu Gln  Ala Ala Leu Glu Lys  His His Ile 
    1310                 1315                 1320             


Asn Pro  Glu Cys Ile Trp Met  Thr Ser Asp Gly Lys  Cys Ala Asp 
    1325                 1330                 1335             


Ile Lys  Leu Met Lys Asn Leu  Glu Ser Gln Lys Phe  Thr Tyr Lys 
    1340                 1345                 1350             


Leu Ala  Lys Arg Glu Gly Glu  Lys Thr Glu Arg Lys  Ile Cys Met 
    1355                 1360                 1365             


Asn Ala  Leu Asn Glu Asn Phe  Leu Lys Thr Ile Arg  Thr Ser Leu 
    1370                 1375                 1380             


Glu Tyr  Lys Lys 
    1385         


<210>  375
<211>  1380
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  375

Met Lys Leu Ser Lys Glu Lys Gln Ile Arg Ser Ala Val Ala Asn Lys 
1               5                   10                  15      


Glu Lys Asn Thr Glu Gly Val Leu Tyr Arg Phe Pro Gly Asp Asp Ile 
            20                  25                  30          


Gly Gly Val Gln Ala Gln Met Leu Val Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Leu Gly Asn Lys Pro Lys Glu 
    50                  55                  60                  


Trp Met Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Lys Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Ala Ile Asn Asp Ile Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Lys Glu Ala Asp Lys Lys Ile Arg Asn Met Ser Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Asn Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Ser Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Gly Asn Gln Glu Phe Asp Ser Ile Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Asp Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Ser Ile Gln Asp Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Ile Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Glu Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Asp Gly Leu Asn Glu Phe Met Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Glu Glu Lys Arg Ala Glu Val Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Ser His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Val Asn Lys Gly Lys Phe Tyr Val Trp 
305                 310                 315                 320 


Lys Lys His Glu Cys Gly Lys Lys Glu Asn Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Val Glu Ala Glu Ala Glu Ser Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Ile Phe Phe Glu Asn Asp Thr Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Thr Gly Thr Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Lys Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asn Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Gln Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Tyr Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Leu 
            660                 665                 670         


Val Arg Thr Val Phe Pro Glu Tyr Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Asn Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Arg Thr Leu Arg Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Lys 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Glu Asn Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Cys Ala Gln Asp 
            900                 905                 910         


Ile Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu 
        915                 920                 925             


Leu Ser Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Lys Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Lys Phe Ser Glu Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Thr Asn Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Gly  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Glu Lys Pro Glu  Glu Tyr Glu Lys Ile  Glu Ala Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Ile  Tyr Ala Pro Glu Lys  Asn Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Gln Gly Arg Val Gly  Ala Lys Val 
    1145                 1150                 1155             


Thr Ser  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Glu Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Met Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Val Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Val Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Glu Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asn Ala 
    1280                 1285                 1290             


Lys Asp  Lys Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Asp  Ala Glu Asp Ala Asp  Ser Lys Lys Pro Val  Ile Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Glu  Asp Glu Asp 
    1325                 1330                 1335             


Lys Gln  Lys Gly Lys Glu Asn  Arg Gly Lys Lys Asn  Thr Glu Thr 
    1340                 1345                 1350             


Arg Ser  Asp Ala Glu Lys Asn  Asn Asn Glu Arg Leu  Ser Tyr Asn 
    1355                 1360                 1365             


Pro Phe  Ala Asn Phe Asp Phe  Lys Leu Pro Asn Lys  
    1370                 1375                 1380 


<210>  376
<211>  1366
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  376

Met Lys Leu Ser Lys Glu Asn His Ile Lys Ser Ala Val Ala Ile Ser 
1               5                   10                  15      


Gly Lys Glu Gly Asn Ile Ala Gly Thr Leu Tyr Lys Ile Pro Gly Glu 
            20                  25                  30          


Gly Thr Val Asp Leu Lys Lys Gln Met Leu Glu Arg Asp Lys Ala Val 
        35                  40                  45              


Lys Arg Leu Tyr Asn Ile Phe Asn Gln Ile Gln Leu Gly Thr Gln Pro 
    50                  55                  60                  


Lys Glu Trp Lys Glu Asn Arg Asn Leu Ser Ala Glu Glu Asn Thr Arg 
65                  70                  75                  80  


Arg Met His Gln Gln Ala Val Lys Ile Gln Asn Tyr Lys Met Lys Lys 
                85                  90                  95      


Ala Cys Ser Lys Tyr Val Asn Ser Ile Arg Lys Thr Ile Asn Gly Leu 
            100                 105                 110         


Leu Phe Tyr Asp Arg Ile Ile Lys Thr Thr Gln Gln Asn Lys Val Lys 
        115                 120                 125             


Ser Asp Arg Leu Lys Met Met Arg Lys Asn Glu Asp Ile Ile Ser Lys 
    130                 135                 140                 


Met Lys Asn Glu Asn Ile Leu Gln Gln Phe Lys Val Glu Gly Glu Asn 
145                 150                 155                 160 


Gly Lys Phe Glu Lys Gly Lys Leu Glu Asp Phe Val Thr Leu Ala Leu 
                165                 170                 175     


Arg Ser Ser Leu Ile Val Ser Arg Tyr Lys Gly Lys Asp Phe Asn Ser 
            180                 185                 190         


Val Ala Ala Val Val Val Phe Leu Asp Asn Ile Gly Asn Asn Asn Ile 
        195                 200                 205             


Ser His Glu Asp Glu Arg Thr Ile Asn Ile Leu Leu Asn Leu Ile Arg 
    210                 215                 220                 


Glu Asp Phe Thr Lys Leu Asn Pro Asn Lys Asp Asn Thr Gln Gly Ala 
225                 230                 235                 240 


Arg Leu Ile Arg Ser Val Thr Asn Gln Asn Met Leu Val Gln Pro Gln 
                245                 250                 255     


Asn Asp Arg Phe Ser Phe Pro Ser Val Ser Asp Ser Gly Lys Ser Lys 
            260                 265                 270         


Val Ser Asn Lys Asn Val Glu Lys Ser Gly Leu Asp Asn Phe Leu Leu 
        275                 280                 285             


Asp Tyr Ala Asn Leu Asn Lys Glu Glu Arg Glu Glu Lys Leu Arg Lys 
    290                 295                 300                 


Leu Arg Arg Ile Ile Asp Val Tyr Phe Ser Ala Pro Ile Thr Tyr Gln 
305                 310                 315                 320 


Lys Asp Met Asp Val Thr Leu Ser Glu Glu Val Val Lys Tyr Lys Phe 
                325                 330                 335     


Asp Val Trp Ile Lys His Asn Gln Gly Lys Lys Asp Asn Asn Met Phe 
            340                 345                 350         


Val Asp Val Pro Asp Val Leu Val Lys Ala Glu Thr Asp Gly Glu Lys 
        355                 360                 365             


Ile Asp Ala Val Ile Glu Lys Gln Ala Arg Lys Glu Leu Thr Asp Arg 
    370                 375                 380                 


Val Arg Glu Gln Asn Met Ile Cys Tyr Arg Tyr Thr Gln Ala Ile Val 
385                 390                 395                 400 


Lys Lys Tyr Asn Ala Asn Glu Ala Leu Phe Phe Glu Asn Asp Asp Ile 
                405                 410                 415     


Asn Gln Tyr Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu 
            420                 425                 430         


Lys Ser Cys Lys Ile Gly Thr Leu Phe Lys Leu Arg Lys Gly Tyr Leu 
        435                 440                 445             


Thr Glu Lys Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr 
    450                 455                 460                 


Ile Ala Ile Gly Lys Val Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp 
465                 470                 475                 480 


Asn Asp Asn Lys Val Lys Lys Leu Gly Asp Ile Ser Glu Lys Ile Arg 
                485                 490                 495     


Ser Gly Ile Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Thr 
            500                 505                 510         


Leu Gln Arg Glu Leu Ala Val Asn Val Ala Phe Ser Ala Asn Asn Leu 
        515                 520                 525             


Ala Arg Ala Val Cys Asp Met Ser Asn Leu Ser Asp Lys Thr Ser Asp 
    530                 535                 540                 


Phe Leu Leu Trp Lys Pro Asp Asp Ile Asn Asp Lys Met Lys Lys Ser 
545                 550                 555                 560 


Thr Gly Asn Asp Asp Asp Asn Glu Lys Asn Lys Lys Ala Val Cys Ala 
                565                 570                 575     


Val Leu Gln Phe Phe Gly Gly Lys Ser Leu Trp Lys Asp Val Asp Phe 
            580                 585                 590         


Glu Lys Ala Tyr Lys Asn Ala Gly Lys His Gly Tyr Gly Val Tyr Tyr 
        595                 600                 605             


Ile Asn Asp Leu Arg Lys Ala Ile Phe Ala Ala Arg Asn Val Ser Phe 
    610                 615                 620                 


His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys Trp Asn Val Glu Phe 
625                 630                 635                 640 


Leu Gly Lys Met Phe Glu Lys Glu Thr Glu Phe Cys Leu Asp Ile Glu 
                645                 650                 655     


Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Met Phe Tyr Lys Ser Cys 
            660                 665                 670         


Asn Leu Glu Lys Met Leu Asn His Leu Tyr Ser Arg Lys Val Ser Arg 
        675                 680                 685             


Ala Ala Gln Val Pro Ser Tyr Asn Thr Val Phe Val Arg Lys Thr Phe 
    690                 695                 700                 


Pro Glu Tyr Val Asn Asn Val Leu Lys Tyr Lys Lys Pro Gly Thr Asp 
705                 710                 715                 720 


Ala Glu Ile Leu Asp Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu Leu Lys 
                725                 730                 735     


Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Lys Asp Ala Phe Lys Tyr 
            740                 745                 750         


Leu Glu Lys Ala Val Tyr Asn Leu Asn Ser Lys Asn Ile Asn His Asp 
        755                 760                 765             


Asn Ser Gly Lys Lys Ile Ser Gly Asp Glu Leu Lys Arg Lys Lys Ala 
    770                 775                 780                 


Ser Glu Ser Phe Gln Lys Arg Phe Ala Glu Ile Lys Lys Val Ser Ala 
785                 790                 795                 800 


Ser Ser Ile Ser Tyr Val Cys Gln Val Phe Met Thr Asp Tyr Asn Gln 
                805                 810                 815     


Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn Asp Ser Leu Phe 
            820                 825                 830         


Asp Lys Pro Ile Tyr Gln His Phe Lys Met Leu Leu Lys Glu Thr Ile 
        835                 840                 845             


Lys Ser Ala Phe Ala Ala Tyr Leu Lys Asp Asn Asn Asn Lys Glu Leu 
    850                 855                 860                 


Phe Gly Phe Ile Gly Glu Pro Leu Lys Ile Lys Lys Asn Asp Asp Thr 
865                 870                 875                 880 


Lys Ala Val Glu Lys Glu Asp Phe Leu Pro Gly Trp Lys Ser Glu Lys 
                885                 890                 895     


Tyr Ser Leu Leu Ile Glu Arg Val Lys Lys Ser Pro Glu Leu Gln Met 
            900                 905                 910         


Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met 
        915                 920                 925             


Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Ala Ser Asp Ile Asn Arg 
    930                 935                 940                 


Arg Ala Asn Val Met Gly Asn Lys Leu His Val Glu Val Leu Asp Lys 
945                 950                 955                 960 


Asp Lys Val Lys Glu Trp Ile Gln Val Ile Glu Val Cys Leu Leu Leu 
                965                 970                 975     


Ser Ser Arg Ile Ser Asn Gln Phe Asp Asp Tyr Phe Ile Asp Glu Asp 
            980                 985                 990         


Asp Tyr Ala Gly Tyr Leu Lys Ser  Tyr Val Asp Phe Pro  Asp Lys Asn 
        995                 1000                 1005             


Met Pro  Ser Ala Tyr Ser Ala  Leu Val Asp Phe Ser  Ala Gln Gly 
    1010                 1015                 1020             


Lys Ile  Asp Leu Tyr Val Asp  Ser Lys Asn Pro Lys  Ile Asn Arg 
    1025                 1030                 1035             


Asn Ile  Val Gln Ser Lys Leu  Phe Ala Ala Asp His  Ile Leu Gly 
    1040                 1045                 1050             


Asn Gly  Gln Ile Val Gln Leu  Val Ser Lys Asp Asp  Ile Val Glu 
    1055                 1060                 1065             


Phe Tyr  Asn Leu Lys Ala Lys  Ile Ala Asp Ser Lys  Ile Lys Gly 
    1070                 1075                 1080             


Glu Asn  Ile Ser Glu Lys Glu  Gln Arg Asn Ile Leu  Arg Tyr Gln 
    1085                 1090                 1095             


Lys Leu  Lys Asn Lys Val Glu  Leu Arg Asp Ile Val  Glu Tyr Gly 
    1100                 1105                 1110             


Glu Ile  Ile Asn Glu Leu Ile  Gly Gln Leu Ile Asn  Trp Ser Phe 
    1115                 1120                 1125             


Met Arg  Glu Arg Asp Leu Leu  Tyr Phe Gln Leu Gly  Phe His Tyr 
    1130                 1135                 1140             


Asn Cys  Leu Arg Asn Asn Ser  Glu Lys Pro Glu Glu  Tyr Lys Lys 
    1145                 1150                 1155             


Ile Glu  Ala Asp Asp Ile Ser  Ile Asn Asp Ala Val  Leu Tyr Gln 
    1160                 1165                 1170             


Ile Ile  Gly Met Tyr Val Asn  Gly Ile Pro Val Tyr  Thr Ser Asp 
    1175                 1180                 1185             


Asn Asn  Lys Leu Lys Gly Glu  Cys Ala Asn Gly Gly  Ala Gly Gly 
    1190                 1195                 1200             


Lys Ile  Ile Ala Phe Cys Lys  Tyr Ser Glu Tyr Leu  Gly Phe Lys 
    1205                 1210                 1215             


Lys Ala  Thr Leu Tyr Glu Ala  Gly Leu Glu Val Phe  Glu Val Val 
    1220                 1225                 1230             


Ala Glu  His Asp Asp Ile Ile  Lys Leu Arg Asn Gly  Ile Glu His 
    1235                 1240                 1245             


Phe Lys  Tyr Tyr Leu Gly Asn  Tyr Arg Ser Ile Met  Ser Leu Tyr 
    1250                 1255                 1260             


Ser Glu  Val Phe Asp Arg Phe  Phe Thr Tyr Asp Leu  Lys Tyr Gln 
    1265                 1270                 1275             


Lys Asn  Val Leu Asn Leu Leu  Gln Asn Ile Leu Leu  Arg His Asn 
    1280                 1285                 1290             


Val Val  Ile Val Pro Asp Phe  Glu Ser Gly Thr Lys  Lys Val Gly 
    1295                 1300                 1305             


Asp Asn  Thr Lys Gln Ala Ala  Lys Ile Ser Ile Lys  Asn Ile Gln 
    1310                 1315                 1320             


Ser Asp  Lys Phe Thr Tyr Lys  Ile Asn Gly Gly Thr  Ala Ser Ile 
    1325                 1330                 1335             


Asp Ala  Lys Asp Asp Arg Tyr  Leu Glu Thr Ile Lys  Lys Ile Leu 
    1340                 1345                 1350             


Tyr Tyr  Pro Glu Tyr Asp Lys  Asp Ser Ser Gly Val  Cys 
    1355                 1360                 1365     


<210>  377
<211>  1053
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  377

Met Arg Val Ser Lys Val Lys Val Gly Lys Glu Met Val Leu Met His 
1               5                   10                  15      


Arg Thr Asp Lys Glu Gly Ala Leu Val Leu Glu Glu Ser Lys Lys Asn 
            20                  25                  30          


Ile Thr Asp Lys Ile Lys Cys Asn Lys Lys Asp Ser Phe His Leu Ser 
        35                  40                  45              


Ile Leu Asn Gln Thr Leu Val Lys Lys Asn Arg Asn Lys Asp Leu Glu 
    50                  55                  60                  


Thr Ile Ile Tyr Ser Val Ile Lys Gly Gly Gln Leu Lys Leu Glu Ser 
65                  70                  75                  80  


Asp Lys Gln Leu Ser Glu Ile Glu Ile Lys Asn Ser Leu Thr Asn Lys 
                85                  90                  95      


Phe Lys Glu Gln Phe Tyr Tyr Asn Asn Lys Glu Gly Ser Lys Met Glu 
            100                 105                 110         


Phe Asn Leu Ala Ala Leu Ile Leu Lys Phe Tyr Ser Thr Arg Asp Ile 
        115                 120                 125             


Lys Glu Leu Gln Pro Tyr Lys Asp Trp Val Asp Trp Tyr Ile Asp Phe 
    130                 135                 140                 


Lys Ser Glu Arg Leu Glu Lys Ser Ile Ile Val Asn Lys Ile Asn Phe 
145                 150                 155                 160 


Gln Thr Lys Arg Lys Glu Thr Leu Lys Asp Phe Glu Gln Glu Leu Ile 
                165                 170                 175     


Lys Thr Gly Lys Ile Asn Ile Ser Asp Ile Ala Ser Leu Tyr Gly Ile 
            180                 185                 190         


Glu Gln Leu Ile Lys Thr Phe Glu Gly Ile Met Ala Leu Tyr Phe Met 
        195                 200                 205             


Gln Val Lys Lys Arg Asp Phe His Leu Asn Tyr Lys Leu Lys Ser Ala 
    210                 215                 220                 


Leu Gln Ile His Gln Ser Lys Leu Phe Ser Ile Gln Ser Asn Arg Asp 
225                 230                 235                 240 


Asn Leu Lys Leu Gly Leu Phe Asn Ile Glu Val Thr Lys Tyr Phe Gln 
                245                 250                 255     


His Tyr Phe Pro Ile Lys Val Glu Asp Lys Arg Lys Thr Asp Asp Asp 
            260                 265                 270         


Val Lys Tyr Tyr Leu Gln Glu Lys Val Leu Ile Asn Thr Ile Ser Asn 
        275                 280                 285             


Gln Ile Glu Asn Ala Val Arg Ser Thr Leu Ile Thr Lys Gly Lys Phe 
    290                 295                 300                 


Lys Ala His Asn Ile Glu Leu Asp Ser Ile Asn Ser Glu Ile Leu Thr 
305                 310                 315                 320 


Glu Ile Lys Ile Lys Asp Ala Phe Val Leu Asn Leu Ile Asp Ala Cys 
                325                 330                 335     


Ala Phe Ala Ala Asn Asn Ile Arg Asn Ile Val Asp Asn Gly Gln Val 
            340                 345                 350         


Lys Asp Ile Leu Gly Asn Glu Asp Phe Asn Tyr Ser Leu Asn Lys His 
        355                 360                 365             


Asn Val Asn Lys Glu Leu Tyr Lys Ile Phe Phe Asp Asn Glu Tyr Lys 
    370                 375                 380                 


Asp Ile Asn Glu Asn Leu Trp Ala Leu Arg Gly Ser Val Gln Gln Ile 
385                 390                 395                 400 


Arg Asn Lys Ile Tyr His Tyr Asn Val Asn Ser Ile Ala Asp Ile Phe 
                405                 410                 415     


Asn Ile Cys Thr Tyr Glu Asn Gln Lys Tyr Lys Asn Arg Pro Tyr Leu 
            420                 425                 430         


Asp Thr Pro Phe Lys Glu Glu Leu Lys Asn Glu Ile Glu Asn Ile Pro 
        435                 440                 445             


Asn Leu Ile Leu Ser Lys Phe Asn Lys Asn Asn Ile Leu Lys Tyr Tyr 
    450                 455                 460                 


Ser Asp Asn Asp Leu Asn Ala Ile Ile Glu Lys Leu Lys Phe Asn Leu 
465                 470                 475                 480 


Cys Arg Pro Ser Glu Met Phe Ile Pro Ser Phe Lys Ser Val Phe Asp 
                485                 490                 495     


Thr Ala Arg Val Leu Pro Asn Asn His Tyr Leu Gly Val Lys Asn Tyr 
            500                 505                 510         


Phe Ser Lys Asp Asn Cys Ile Asn Glu Glu His Tyr Gln Ala Cys Arg 
        515                 520                 525             


Phe Ile Ala Lys Gln Ile Tyr Asn Tyr Gln Phe Leu Asn Gln Ser Val 
    530                 535                 540                 


Asp Asp Asn Glu Phe Lys Ile Val Val Asn Glu Ile Ile Glu Ser Cys 
545                 550                 555                 560 


Lys Asn Asn Val Ala Lys Lys Asn Asn Ile Asn Lys Tyr Ala Phe His 
                565                 570                 575     


Glu Ile Glu Lys Met Glu Glu Thr Asp Thr Arg Val Asp Tyr Leu Lys 
            580                 585                 590         


Lys Ile His Ser Gln Ile Ile Leu Ser Asn Ala Asn Lys Asp Asp Lys 
        595                 600                 605             


Thr Glu Lys Ser Asn Phe Glu Lys Phe Leu Leu Tyr Ile Tyr Ile Lys 
    610                 615                 620                 


Leu Phe Asp Asn Phe Ile Asp Gln His Tyr Lys Asp Leu Ile Val Leu 
625                 630                 635                 640 


Gly Tyr Thr Tyr Asp Val Asn Asn Arg Val Ile Glu Lys Asp Lys Ile 
                645                 650                 655     


Glu Val Glu Lys Ile Lys Leu Ile Glu Asp Asn Asp Asn Thr Ala Lys 
            660                 665                 670         


Ile Val Pro Phe Tyr Ile Phe Cys Lys Leu Leu Asp Ser Asn His Leu 
        675                 680                 685             


Ser Asn Leu Arg Asn Glu Ile Ile Lys Tyr Asn Ala Ile Ser Lys Lys 
    690                 695                 700                 


Asn Asp Ser Thr Ser Asn Arg Leu Glu Ser Ser Leu Pro Ile Asp Asn 
705                 710                 715                 720 


Leu Leu Phe Ile Ile Glu Met Cys Leu Leu Ser Val Asp Asn Ser Tyr 
                725                 730                 735     


Gly Lys Pro Asn Glu Thr Tyr Lys Lys Phe Ile Val Asp Arg Ile Asn 
            740                 745                 750         


Thr Asp Asn Leu Tyr Ser Ala Gln Asp Asn Glu Thr Leu Ile Leu His 
        755                 760                 765             


Ser Asn Ile Glu Leu Leu Asn Lys Tyr Gly Thr Ile Ser Ile Leu Glu 
    770                 775                 780                 


Lys Leu Ile Ser His Glu Gly Ser Ile Phe Lys Val Thr Gln Gln Asp 
785                 790                 795                 800 


Tyr Asn Ile Trp Glu Glu Lys Arg Glu Asn Ile Glu Gly Lys Gln Lys 
                805                 810                 815     


Glu Ile Ile Glu Leu His Asn Lys Trp Ser Gln Val Gln Glu Lys Leu 
            820                 825                 830         


Lys Gly Leu Lys Lys Glu Glu Lys Glu Lys Arg Lys Lys Ile Arg Lys 
        835                 840                 845             


Glu Glu Ser Asp Ile Lys Asp Lys Tyr Lys Cys Ile Val Thr Glu Val 
    850                 855                 860                 


Thr Ser Phe Asn Gln Leu Asp Asn Lys Leu His Phe Val Ala Leu Arg 
865                 870                 875                 880 


Lys Leu His Asn Leu Thr Ile Glu Ile Leu Gly Arg Phe Val Gly Phe 
                885                 890                 895     


Thr Asn Met Phe Glu Arg Asp Phe Gln Tyr Leu Asn Asp Glu Leu Asn 
            900                 905                 910         


Ser Asn Met Lys Phe Asp Lys Gly Leu Pro Asn Asn Ile Pro Asn Glu 
        915                 920                 925             


Tyr Asn Lys Phe Phe Leu Ser Val Asn Tyr Arg Asp Ile Arg Asn Tyr 
    930                 935                 940                 


Ile Ala His Phe Asn Tyr Ile Ser Asn Lys Ser Ile Lys Tyr Ser Met 
945                 950                 955                 960 


Ile Asp Ile Ile Asn Glu Leu Arg Glu Leu Leu Trp Tyr Asp Arg Lys 
                965                 970                 975     


Leu Lys Asn Ala Val Ala Lys Ser Ile Ile Asp Ile Phe Asp Arg Asn 
            980                 985                 990         


Gly Met Glu Leu Lys Leu Lys Phe  Ser Ile Thr Glu His  Lys Leu Asp 
        995                 1000                 1005             


Ile Asp  Tyr Ile Lys Pro Lys  Lys Ile Tyr His Leu  Gly Thr Lys 
    1010                 1015                 1020             


Lys Gly  Lys Phe Glu Lys Asp  Glu Ile Thr Thr Asn  Gln Val Ser 
    1025                 1030                 1035             


Glu Glu  Tyr Cys Lys Met Cys  Glu Ala Leu Leu Val  Met Lys Lys 
    1040                 1045                 1050             


<210>  378
<211>  1392
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  378

Met Gly Asn Leu Phe Gly His Lys Arg Trp Tyr Glu Val Pro Asp Lys 
1               5                   10                  15      


Lys Asn Phe Lys Ile Lys Arg Lys Val Lys Ile Lys Arg Asn Tyr Arg 
            20                  25                  30          


Gly Asn Lys Tyr Ile Leu Asn Ile Asn Glu Asn Asn Asn Lys Glu Lys 
        35                  40                  45              


Ile Asp Asn Asn Lys Phe Ile Gly Glu Phe Val Asn Tyr Lys Lys Asn 
    50                  55                  60                  


Asn Asn Val Leu Lys Glu Phe Lys Arg Lys Phe His Thr Gly Asn Ile 
65                  70                  75                  80  


Leu Phe Lys Leu Lys Gly Lys Glu Gly Ile Ile Arg Ile Glu Asn Asn 
                85                  90                  95      


Asp Asp Phe Leu Glu Thr Glu Glu Val Val Leu Tyr Ile Glu Val Tyr 
            100                 105                 110         


Gly Lys Ser Glu Lys Leu Lys Ala Leu Glu Ile Thr Lys Lys Lys Ile 
        115                 120                 125             


Ile Asp Glu Ala Ile Arg Gln Gly Ile Thr Lys Asp Asp Lys Lys Ile 
    130                 135                 140                 


Glu Ile Lys Arg Gln Lys Ile Glu Ile Asn Ile Arg Asp Glu Tyr Thr 
145                 150                 155                 160 


Asn Lys Thr Ala Asp Asp Tyr Ser Val Ile Leu Arg Ile Ile Glu Asn 
                165                 170                 175     


Asp Glu Leu Glu Thr Lys Lys Ser Ile Tyr Glu Ile Phe Lys Asn Ile 
            180                 185                 190         


Asn Met Asn Leu Tyr Lys Ile Ile Glu Lys Ile Ile Val Asn Glu Thr 
        195                 200                 205             


Gly Lys Val Phe Glu Asn Arg Tyr Tyr Glu Glu His Leu Arg Glu Lys 
    210                 215                 220                 


Leu Leu Lys Asp Asp Lys Ile Asp Val Ile Leu Thr Asn Phe Ile Glu 
225                 230                 235                 240 


Ile Arg Glu Lys Ile Lys Ser Asn Leu Glu Val Met Gly Phe Val Lys 
                245                 250                 255     


Phe Tyr Leu Asn Val Gly Gly Asp Lys Lys Lys Ser Glu Asn Lys Lys 
            260                 265                 270         


Ile Phe Val Glu Lys Ile Leu Asn Thr Asn Val Asp Leu Thr Val Glu 
        275                 280                 285             


Asp Ile Val Asp Phe Ile Val Lys Glu Leu Lys Phe Trp Asn Ile Thr 
    290                 295                 300                 


Lys Arg Ile Glu Lys Val Lys Glu Phe Asn Asn Lys Ser Leu Glu Asn 
305                 310                 315                 320 


Lys Arg Asn Arg Thr Tyr Ile Lys Ser Tyr Val Leu Leu Asp Lys His 
                325                 330                 335     


Glu Lys Phe Lys Ile Glu Arg Glu Asn Lys Lys Asp Lys Ile Val Lys 
            340                 345                 350         


Phe Phe Val Glu Asn Ile Lys Asn Asn Ser Ile Lys Glu Lys Ile Glu 
        355                 360                 365             


Lys Ile Leu Ala Glu Phe Lys Ile Asn Glu Leu Ile Lys Lys Leu Glu 
    370                 375                 380                 


Lys Glu Leu Lys Lys Gly Asn Cys Asp Thr Glu Ile Phe Gly Ile Phe 
385                 390                 395                 400 


Lys Lys His Tyr Lys Val Asn Phe Asp Ser Lys Lys Phe Ser Lys Lys 
                405                 410                 415     


Ser Asp Glu Glu Lys Glu Leu Tyr Lys Ile Ile Tyr Arg Tyr Leu Lys 
            420                 425                 430         


Gly Arg Ile Glu Lys Ile Leu Val Asn Glu Gln Lys Ala Arg Leu Lys 
        435                 440                 445             


Lys Met Glu Lys Ile Glu Ile Glu Lys Ile Leu Asn Glu Ser Ile Leu 
    450                 455                 460                 


Ser Glu Lys Ile Leu Lys Arg Val Lys Gln Tyr Thr Leu Glu His Ile 
465                 470                 475                 480 


Met Tyr Leu Gly Lys Leu Val His Asn Asn Ile Asp Ile Thr Thr Val 
                485                 490                 495     


Asn Thr Asn Asp Phe Ser Arg Leu His Ala Lys Glu Glu Leu Asp Leu 
            500                 505                 510         


Glu Leu Ile Thr Phe Phe Ala Ser Thr Asn Met Glu Leu Asn Lys Ile 
        515                 520                 525             


Phe Ser Arg Lys Asn Ile Asn Asn Asp Gly Asn Ile Asp Phe Phe Gly 
    530                 535                 540                 


Gly Asp Gly Glu Lys Asn Tyr Ile Leu Asp Lys Lys Ile Ser Asn Ser 
545                 550                 555                 560 


Lys Ile Glu Ile Ile Arg Lys Leu Asp Phe Ile Asp Asn Lys Asn Asp 
                565                 570                 575     


Ile Thr Asn Asn Phe Ile Glu Lys Phe Ile Lys Ile Gly Thr Asn Glu 
            580                 585                 590         


Arg Asn Arg Ile Leu His Ala Asn Asn Lys Gly Arg Glu Ile Gln Glu 
        595                 600                 605             


Ala Lys Asp Asn Tyr Gly Lys Val Thr Lys Ile Ile Glu Asn Leu Lys 
    610                 615                 620                 


Ile Ser Asp Glu Glu Val Ser Lys Ala Leu Asn Leu Asp Val Val Phe 
625                 630                 635                 640 


Lys Asn Lys Lys Asp Ile Ile Asn Lys Ile Asn Asp Ile Lys Ile Ser 
                645                 650                 655     


Glu Glu Asn Ser Asn Asp Ile Lys Tyr Leu Pro Ser Phe Ser Lys Met 
            660                 665                 670         


Leu Arg Glu Ile Leu Asn Leu Tyr Arg Asn Asn Pro Lys Asn Glu Pro 
        675                 680                 685             


Phe Asp Thr Ile Glu Thr Glu Lys Ile Val Leu Asn Ala Leu Ile Tyr 
    690                 695                 700                 


Val Asn Lys Glu Leu Tyr Lys Lys Leu Ile Leu Glu Asp Asp Leu Lys 
705                 710                 715                 720 


Glu Asn Gly Asn Lys Asn Ile Phe Leu Gln Glu Leu Lys Lys Thr Leu 
                725                 730                 735     


Gly Asn Ile Asn Glu Lys Asp Lys Asn Ile Ile Glu Ser Tyr Tyr Lys 
            740                 745                 750         


Asn Ala Gln Ile Ser Ala Ser Lys Asp Asn Asn Lys Ala Ile Lys Lys 
        755                 760                 765             


Tyr Gln Lys Lys Val Ile Glu Cys Tyr Ile Lys Tyr Leu Glu Glu Asn 
    770                 775                 780                 


Tyr Lys Glu Leu Phe Asp Phe Ser Asp Phe Lys Met Asn Ile Gln Glu 
785                 790                 795                 800 


Ile Lys Lys Gln Ile Lys Glu Ile Asn Asp Asn Lys Thr Tyr Lys Arg 
                805                 810                 815     


Ile Thr Ile Lys Thr Ser Asp Lys Ser Ile Val Ile Asn Asn Asp Phe 
            820                 825                 830         


Glu Tyr Thr Ile Ser Ile Phe Ala Leu Leu Asn Ser Asn Thr Val Ile 
        835                 840                 845             


Asn Lys Ile Arg Asn Arg Phe Phe Ala Ile Ser Val Trp Leu Asn Thr 
    850                 855                 860                 


Ser Glu Tyr Gln Asn Ile Ile Glu Ile Leu Asp Glu Ile Met Gln Leu 
865                 870                 875                 880 


Asn Thr Leu Arg Asn Glu Cys Ile Thr Glu Asn Trp Asn His Asn Leu 
                885                 890                 895     


Lys Glu Phe Ile Gln Lys Met Leu Asp Val Glu Lys Glu Ile Gly Asn 
            900                 905                 910         


Phe Glu Ile Lys Thr Lys Lys Glu Ile Phe Asp Ile Tyr Tyr Glu Glu 
        915                 920                 925             


Ile Lys Asn Asp Met Ile Val Lys Ile Asn Asp Asn Lys Ile Gln Lys 
    930                 935                 940                 


Ile Leu Asn Lys Cys Leu Lys Glu Ile Thr Gly Phe Ser Ser Asn Asn 
945                 950                 955                 960 


Glu Tyr Met Phe Lys Asn Leu Gly Lys Leu Thr Leu Glu Glu Arg Asp 
                965                 970                 975     


Phe Ile Leu Ser Asn Lys Lys Leu Ile Glu Lys Asn Ile Asp Glu Ile 
            980                 985                 990         


Ile Gly Glu Lys Leu Asp Ala Ile  Lys Glu Lys Val Leu  Leu Lys Lys 
        995                 1000                 1005             


Val Phe  Asn Ser Glu Phe Leu  Glu Lys Tyr Lys Glu  Glu Ile Asp 
    1010                 1015                 1020             


Asn Leu  Val Glu Asp Thr Glu  Ser Glu Asn Lys Asn  Lys Phe Glu 
    1025                 1030                 1035             


Glu Ile  Tyr Tyr Pro Lys Glu  His Lys Asn Glu Leu  Tyr Ile Tyr 
    1040                 1045                 1050             


Lys Lys  Asn Leu Phe Leu Asn  Ile Gly Asn Pro Asn  Phe Asp Lys 
    1055                 1060                 1065             


Ile Tyr  Gly Leu Ile Ser Asn  Asp Ile Lys Met Ala  Asp Ala Lys 
    1070                 1075                 1080             


Phe Leu  Phe Asn Ser His Gly  Lys Asn Ile Arg Asn  Asn Lys Ile 
    1085                 1090                 1095             


Ala Glu  Ile Asp Val Ile Leu  Lys Lys Leu Asn Asn  Lys Leu Asn 
    1100                 1105                 1110             


Gly Tyr  Ser Lys Glu Tyr Lys  Glu Lys Tyr Ile Glu  Lys Leu Lys 
    1115                 1120                 1125             


Glu Asn  Asn Asp Phe Phe Ala  Lys Asn Ile Gln Asn  Glu Asn Tyr 
    1130                 1135                 1140             


Asn Ser  Phe Glu Glu Phe Lys  Glu Asp Tyr Asn Lys  Val Ser Glu 
    1145                 1150                 1155             


Tyr Lys  Lys Ile Arg Asp Leu  Val Glu Phe Asn Tyr  Leu Asn Lys 
    1160                 1165                 1170             


Ile Glu  Ser Tyr Leu Ile Asp  Ile Asn Trp Lys Leu  Ala Ile Gln 
    1175                 1180                 1185             


Met Ala  Arg Phe Glu Arg Asp  Met His Tyr Ile Val  Asn Gly Leu 
    1190                 1195                 1200             


Lys Lys  Leu Asn Phe Ile Asn  Leu Asn Gly Tyr Asn  Thr Gly Ile 
    1205                 1210                 1215             


Ser Arg  Ala Tyr Pro Lys Tyr  Asn Asp Ser Asp Ser  Asn Lys Asn 
    1220                 1225                 1230             


Cys Lys  Lys Phe Tyr Glu Thr  Thr Ala Tyr Tyr Lys  Phe Phe Asp 
    1235                 1240                 1245             


Asp Lys  Ser Tyr Arg Glu Leu  Glu Asp Ile Cys Tyr  Glu Phe Gly 
    1250                 1255                 1260             


Ile Asp  Leu Arg Lys Asn Ser  Asn Ile Gln Ala Lys  Glu Glu Arg 
    1265                 1270                 1275             


Asn Ile  Arg Asn Tyr Ile Ser  His Phe Tyr Ile Val  Arg Asn Pro 
    1280                 1285                 1290             


Phe Ala  Asp Tyr Ser Ile Ala  Glu Gln Ile Asp Arg  Val Ser Asn 
    1295                 1300                 1305             


Leu Leu  Ser Tyr Ser Thr Arg  Tyr Asn Asn Ser Thr  Tyr Ala Ser 
    1310                 1315                 1320             


Val Phe  Glu Val Phe Lys Lys  Asp Val Asp Leu Asp  Tyr Asp Glu 
    1325                 1330                 1335             


Leu Lys  Lys Lys Phe Lys Leu  Ile Gly Asn Asn Asp  Ile Leu Glu 
    1340                 1345                 1350             


Arg Leu  Met Lys Pro Lys Lys  Val Ser Val Leu Glu  Leu Glu Ser 
    1355                 1360                 1365             


Tyr Asn  Ser Asp Tyr Ile Lys  Asn Leu Ile Ile Glu  Leu Leu Thr 
    1370                 1375                 1380             


Lys Ile  Glu Asn Thr Asn Asp  Thr Leu 
    1385                 1390         


<210>  379
<211>  1185
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  379

Met Lys Val Thr Lys Ile Asp Gly Leu Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ile Glu Asp Ala Ser Gln Lys Asn Glu Thr 
            20                  25                  30          


Leu Glu Arg Leu Glu Asn Leu Lys Gly Ile Lys Leu Gly Ser Tyr Ile 
        35                  40                  45              


Lys Asn Pro Asp Lys Thr Lys Asn Lys Asp Asn Lys Lys Arg Arg Lys 
    50                  55                  60                  


Gly Leu Lys Glu Tyr Phe Ser Glu Ile Thr Leu Arg Lys Glu Asn Glu 
65                  70                  75                  80  


Lys Tyr Val Leu Leu Lys Gly Lys Lys Leu Lys Lys Ile Asn Asn Asp 
                85                  90                  95      


Ile Lys Asp Thr Asp Ile Lys Ala Lys Asp Lys Lys Glu Glu Val Phe 
            100                 105                 110         


Asp Ile Leu Lys Glu Ile Leu Lys Leu Asn Leu Leu Ala Asn Asp Ala 
        115                 120                 125             


Glu Glu Lys Ile Gln Phe Asp Ser Ile Lys Leu Lys Asn Val Phe Gly 
    130                 135                 140                 


Lys Asp Phe Ala Lys Lys Glu Leu Gln Ile Lys Ser Ile Glu Glu Ser 
145                 150                 155                 160 


Leu Glu Lys Asn Arg Ala Asp Tyr Arg Lys Glu Phe Ile Glu Ile Glu 
                165                 170                 175     


Asn His Lys Tyr Gly Asn Val Lys Gly Lys Asn Lys Arg Ser Arg Ile 
            180                 185                 190         


Tyr Gly Tyr Tyr Lys Lys Ser Glu Asn His Lys Lys Phe Glu Asp Asn 
        195                 200                 205             


Ile Arg Glu Ala Phe Glu Lys Leu Tyr Thr Glu Glu Asn Ile Lys Lys 
    210                 215                 220                 


Leu Tyr Ser Lys Ile Glu Glu Val Leu Lys Lys Thr His Leu Lys Ser 
225                 230                 235                 240 


Ile Val Arg Glu Phe Tyr Lys Asn Glu Ile Ile Gly Glu Ser Glu Phe 
                245                 250                 255     


Ser Lys Lys Asn Gly Asp Gly Ile Ser Ile Leu Tyr Asn Gln Ile Lys 
            260                 265                 270         


Asp Ser Ile Lys Lys Glu Glu Asn Phe Ile Glu Phe Ile Glu Asn Ile 
        275                 280                 285             


Gly Asn Leu Glu Leu Lys Asp Leu Thr Lys Ser Gln Ile Phe Tyr Lys 
    290                 295                 300                 


Tyr Phe Leu Glu Asn Glu Glu Leu Asn Asp Glu Asn Ile Lys Phe Val 
305                 310                 315                 320 


Phe Cys Tyr Phe Val Glu Ile Glu Val Ser Asp Leu Leu Lys Gly Asn 
                325                 330                 335     


Val Tyr Lys Ala Ser Lys Ile Tyr Glu Asn Lys Ile Lys Asn Ile Phe 
            340                 345                 350         


Glu Tyr Asp Lys Leu Lys Lys Leu Val Ile Asn Lys Leu Glu Asn Lys 
        355                 360                 365             


Leu Asn Asn Tyr Val Arg Asn Cys Gly Lys Tyr Asn Tyr His Met Glu 
    370                 375                 380                 


Asn Gly Asp Ile Ala Thr Ser Asp Ile Asn Met Arg Asn Arg Gln Thr 
385                 390                 395                 400 


Glu Ala Phe Leu Arg Ser Met Ile Gly Val Ser Ser Phe Gly Tyr Phe 
                405                 410                 415     


Ser Leu Arg Asn Ile Leu Gly Val Asn Asp Asp Asp Phe Tyr Glu Ile 
            420                 425                 430         


Glu Glu Asp Leu Thr Lys Asp Glu Arg Lys Lys Glu Ser Ser Thr Leu 
        435                 440                 445             


Lys Lys Val Lys Glu Asp Ile Ala Ser Lys Ser Ile Phe Glu Lys Val 
    450                 455                 460                 


Val Asp Lys Ser Phe Gln Lys Lys Gly Ile Tyr Asn Ile Lys Glu Asn 
465                 470                 475                 480 


Leu Lys Met Phe Tyr Gly Asp Ser Phe Asp Asp Ala Asp Glu Asp Glu 
                485                 490                 495     


Leu Lys Gln Phe Phe Val Asn Met Leu Asn Gly Ile Thr Ser Ile Arg 
            500                 505                 510         


His Arg Val Val His Tyr Asn Met Asn Thr Asn Ser Glu Asn Ile Phe 
        515                 520                 525             


Asn Phe Ser Asp Ile Glu Val Ser Arg Leu Leu Lys Asn Ile Phe Glu 
    530                 535                 540                 


Lys Glu Thr Asp Lys Arg Glu Leu Lys Leu Lys Ile Phe Lys Gln Leu 
545                 550                 555                 560 


Asn Ser Ala Gly Val Phe Asp Tyr Trp Glu Ser Trp Lys Ile Lys Lys 
                565                 570                 575     


Tyr Leu Glu Asn Ile Glu Phe Lys Phe Val Asn Lys Asn Ile Pro Phe 
            580                 585                 590         


Val Pro Ser Phe Thr Lys Leu Tyr Asn Arg Ile Asp Asn Leu Lys Gly 
        595                 600                 605             


Ser Asn Ala Leu Asn Leu Gly Tyr Ile Asn Ile Pro Lys Arg Lys Glu 
    610                 615                 620                 


Val Arg Asp Ser Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu 
625                 630                 635                 640 


Phe Val Glu Glu Phe Val Asn Asn Asn Asp Asn Phe Glu Lys Ile Phe 
                645                 650                 655     


Arg Glu Ile Ile Glu Ile Asn Lys Asn Ala Gly Thr Asn Thr Lys Thr 
            660                 665                 670         


Lys Phe Tyr Lys Leu Glu Lys Phe Glu Thr Leu Lys Ala Asn Thr Pro 
        675                 680                 685             


Thr Glu Tyr Leu Glu Lys Leu Gln Ser Leu His Gln Ile Asn Tyr Asp 
    690                 695                 700                 


Arg Glu Lys Ile Glu Glu Asp Lys Asp Ile Tyr Val Asp Phe Val Gln 
705                 710                 715                 720 


Lys Ile Phe Leu Lys Gly Phe Ile Asn Tyr Leu Gln Glu Ser Gly Ser 
                725                 730                 735     


Leu Lys Tyr Leu Leu Asn Leu Glu Lys Asn Glu Val Ile Ala Asn Lys 
            740                 745                 750         


Lys Ser Ser Tyr Asp Glu Lys Leu Lys Leu Trp Gln Asn Asn Gly Ser 
        755                 760                 765             


Asp Leu Ser Lys Met Pro Glu Glu Ile Tyr Glu Tyr Ile Lys Lys Ile 
    770                 775                 780                 


Lys Ile Asn Lys Ile Asn Tyr Ser Asp Arg Met Ser Ile Phe Tyr Leu 
785                 790                 795                 800 


Leu Leu Lys Leu Ile Asp Tyr Lys Glu Leu Thr Asn Leu Arg Gly Asn 
                805                 810                 815     


Leu Glu Lys Tyr Glu Ser Met Asn Lys Asn Lys Ile Tyr Ser Glu Glu 
            820                 825                 830         


Leu Asn Ile Val Asn Leu Val Ser Leu Asp Asn Asn Lys Val Arg Ala 
        835                 840                 845             


Asn Phe Glu Leu Glu Ala Glu Asp Val Arg Lys Phe Leu Lys Thr Glu 
    850                 855                 860                 


Thr Leu Ile Lys Asp Ala Arg Gln Leu Asn Asn Phe Ser Glu Arg Phe 
865                 870                 875                 880 


Ser Asp Gly Glu Asn Val Ile Lys His Arg Ser Phe Tyr Asn Ile Lys 
                885                 890                 895     


Lys Tyr Gly Ile Leu Asp Leu Leu Glu Lys Ile Val Ala Lys Ala Asp 
            900                 905                 910         


Leu Lys Ile Thr Lys Glu Glu Ile Lys Lys Tyr Glu Asn Leu Gln Lys 
        915                 920                 925             


Glu Leu Glu Lys Asn Asp Phe Tyr Lys Ile Gln Glu Lys Ile His Lys 
    930                 935                 940                 


Lys Tyr Asn Gln Lys Pro Asn Leu Ile Leu Arg Thr Glu Asn Lys Lys 
945                 950                 955                 960 


Asp Phe Asn Asp Tyr Lys Lys Ala Ile Glu Asn Ile Gln Asn Tyr Thr 
                965                 970                 975     


Gln Leu Lys Asn Lys Ile Glu Phe Asn Asp Leu Asn Leu Leu Gln Ser 
            980                 985                 990         


Leu Leu Phe Arg Ile Leu His Arg  Leu Ala Gly Tyr Thr  Ser Leu Trp 
        995                 1000                 1005             


Glu Arg  Asp Leu Gln Phe Lys  Leu Lys Gly Glu Phe  Pro Glu Asp 
    1010                 1015                 1020             


Lys Tyr  Ile Asp Glu Ile Phe  Asn Ser Asp Arg Asn  Asn Asn Gln 
    1025                 1030                 1035             


Lys Tyr  Lys Ser Gly Gly Ile  Ala Tyr Lys Tyr Val  Asp Phe Leu 
    1040                 1045                 1050             


Ile Glu  Lys Glu Glu Gly Lys  Arg Ala Gly Lys Asn  Lys Val Lys 
    1055                 1060                 1065             


Lys Arg  Ser Glu Lys Glu Gly  Ser Phe Ile Ile Arg  Asn Tyr Ile 
    1070                 1075                 1080             


Ala His  Phe Asn Tyr Ile Pro  Asp Ala Glu Lys Ser  Ile Leu Glu 
    1085                 1090                 1095             


Met Leu  Glu Glu Leu Arg Ala  Leu Leu Lys Tyr Asp  Arg Lys Leu 
    1100                 1105                 1110             


Lys Asn  Ala Val Met Lys Ser  Val Lys Asp Ile Phe  Lys Glu Tyr 
    1115                 1120                 1125             


Gly Phe  Ile Val Glu Phe Gly  Ile Ser His Glu Ser  Asn Ser Lys 
    1130                 1135                 1140             


Lys Ile  Lys Val Val Asn Val  Glu Ser Glu Lys Ile  Lys His Leu 
    1145                 1150                 1155             


Lys Asn  Asn Gly Leu Val Thr  Lys Arg Asn Ser Glu  Asp Leu Cys 
    1160                 1165                 1170             


Asn Leu  Val Lys Val Met Leu  Glu Tyr Lys Lys Ser  
    1175                 1180                 1185 


<210>  380
<211>  1425
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  380

Met Lys Leu Ser Lys Val Asp Arg Ile Arg Val Ala Val Gly Lys Thr 
1               5                   10                  15      


Gly Lys Thr Glu Asn Gly Asn Ser Gln Gly Arg Gly Val Leu Tyr Arg 
            20                  25                  30          


Ser Pro Lys Gly Asn Lys Thr Val Ala Val Asp Ala Val Val Glu Glu 
        35                  40                  45              


Arg Ile Arg Asn Ala Asn Arg Leu Tyr Ser Ala Phe Phe Arg Cys Ala 
    50                  55                  60                  


Tyr Pro Glu Glu Pro Glu Arg His Phe Glu Glu Ile Ile Lys Arg Met 
65                  70                  75                  80  


Ala Thr Gly Lys Lys Ser Gly Ala Gln Ile Leu Lys Glu Tyr Ile Gly 
                85                  90                  95      


Tyr Glu Gly Gln Lys Asn Arg Lys Pro Tyr Thr Phe Tyr Val Asn Lys 
            100                 105                 110         


Cys Ala Tyr Arg Pro Ala Gly Lys Glu Leu Gly Gln Val Leu Arg Leu 
        115                 120                 125             


Phe Val Lys Glu Arg Leu Gly Gln Asn Trp Gln Asn Pro Glu Ala Ala 
    130                 135                 140                 


Glu Ala Ala Val Ala Leu Leu Thr Cys Leu Cys Glu Gly Lys Thr Asn 
145                 150                 155                 160 


Arg Tyr Thr Glu Asn Thr Ala Asp Gly Pro Val Leu Thr Glu Leu Ser 
                165                 170                 175     


Glu Gln Thr Val Thr Gln Leu Glu Gln Val Ser Arg Leu Gly Gly Ser 
            180                 185                 190         


Ile Leu Val Pro Lys Thr Glu Arg Leu Glu Thr Ile Val Thr Val Ile 
        195                 200                 205             


Leu Arg Leu Thr Ala Glu Gln Cys Asn Thr Ser Leu Tyr Val Asn Gly 
    210                 215                 220                 


Gly Thr Lys Glu Ala Gln Asp Ala Asp Leu Glu Lys Gln Ile Ala Leu 
225                 230                 235                 240 


Leu Lys Ser Leu Gln Thr Lys Pro Leu Leu Leu Lys Glu Arg Phe Asp 
                245                 250                 255     


Lys Val Thr Lys Gln Thr Ile Arg Asp Glu Gln Lys Leu Ser Glu Phe 
            260                 265                 270         


Ser Tyr Lys Asp Ala Thr Lys Glu Arg Met Glu Ala Val Val Val Arg 
        275                 280                 285             


Met Arg Lys Thr Leu Lys Lys Gly Ala Ser Arg Glu Val Ala Val Glu 
    290                 295                 300                 


Leu Leu Gln Ala Leu Ala Gln Tyr Asp Gly Lys Thr Trp Asp Gly Trp 
305                 310                 315                 320 


Leu Thr Gln Met Leu Glu Thr Glu Ala Ser Lys Lys Lys Leu Lys Asp 
                325                 330                 335     


Phe Ile Leu Ala Val Asn Lys Asp Phe His His Phe His Val Ile Lys 
            340                 345                 350         


Ser Val Lys Asn Thr Ala Val Ala Val Ser His Ser Glu Asp Asn Thr 
        355                 360                 365             


Leu Gln Leu Ser Gly Ala Lys Lys Lys Thr Lys Gly Ala Met Gln Asp 
    370                 375                 380                 


Ala Leu Phe Ala Tyr Ala Gln Ser Glu Glu Ser Ser Asp Glu Thr Leu 
385                 390                 395                 400 


His Arg Ile Lys Arg Ile Leu Phe Thr Tyr Val Leu Gly Gly Arg Gln 
                405                 410                 415     


Asp Asn Thr Leu Arg Leu Thr Glu Lys Thr His Leu Ala Lys Glu Leu 
            420                 425                 430         


Leu Trp Lys Phe Arg Gly Thr Gly Ala Gly Leu Phe Asp Ala Asp Phe 
        435                 440                 445             


Val Pro Glu Glu Glu Arg Ala Gly Glu Ser Gly Arg Lys Ala Gly Ser 
    450                 455                 460                 


Tyr Thr Asp Leu Gly Cys Leu Phe Ala Glu Asp Asp Gly Ile Arg Asn 
465                 470                 475                 480 


Gln Arg Arg Ile Ala Asp Arg Ile Asn Tyr Val Asn Tyr Gly Asn Tyr 
                485                 490                 495     


Leu Arg Met Arg Lys Ala Ala Glu Asp Glu Phe Thr Leu Phe Trp Cys 
            500                 505                 510         


Ala Tyr Ile Lys Asp Tyr Ile Glu Glu Asn Tyr Val Thr Lys Ile Arg 
        515                 520                 525             


Glu Ala Lys Arg Thr Gly Gly Lys Arg Arg Leu Lys Glu Thr Asp Cys 
    530                 535                 540                 


Glu Ala Glu Arg Met Met Glu Lys Cys Trp His Asp Ile Ile Arg Tyr 
545                 550                 555                 560 


Ile Cys Gly Lys Tyr Ile His Ile Gly Lys Ala Val Tyr His Phe Ala 
                565                 570                 575     


Ile Pro Glu Asp Leu Leu Ala Asn Pro Gly Glu Val Arg Ser Phe Gly 
            580                 585                 590         


Asp Val His Ala Lys Tyr Ala Asp Gly Ile Thr Ser Phe Asp Tyr Glu 
        595                 600                 605             


Asp Ile Lys Ala Glu Glu Asn Leu Gln Lys Ser Ile Phe Asn Val Leu 
    610                 615                 620                 


Val Ser Ala Val Ala Asn Tyr Ser Arg Ser Val Val Asp Leu Ser Ser 
625                 630                 635                 640 


Glu Arg Ala Glu Glu Leu Arg Arg Leu Pro Gly Asn Glu Arg Leu Asn 
                645                 650                 655     


Glu Asp Val Leu Met Met Lys Glu Thr His Leu Lys Glu Leu Leu Leu 
            660                 665                 670         


Pro Asp Ala Lys Lys Arg Leu Leu Arg Tyr Phe Gly Gly Tyr Ser Ala 
        675                 680                 685             


Cys Glu Gly Leu Ser Gly Val Thr Ser Glu Glu Leu Ala Trp Glu Met 
    690                 695                 700                 


Arg Thr Val Leu Ser Thr Leu Arg Asn Glu Ser Phe His Tyr Thr Phe 
705                 710                 715                 720 


Gly Lys Lys Lys Lys Leu Asp Tyr Lys Val Ala Lys Gln Leu Trp Met 
                725                 730                 735     


Gln Ala Ile Arg Ala Asn Arg Gln Leu Ile Leu Asp Lys Tyr Tyr Ser 
            740                 745                 750         


Asn Asn Thr Cys Arg Tyr Tyr Ser Pro Asn Ser Ile Lys Ala Leu Ile 
        755                 760                 765             


Glu Gln Gly Tyr Arg Ser Tyr Glu Glu Arg Glu Ala Gln Ile Pro Ala 
    770                 775                 780                 


Phe Lys Thr Val Trp Lys Lys Ala Glu Leu Ala Lys Tyr Leu Ala Asp 
785                 790                 795                 800 


Lys Lys Val Met Pro Ala Glu Ile Ser Gly Glu Glu Lys Glu Arg Val 
                805                 810                 815     


Ile Phe Gln Gly Ala Phe Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg 
            820                 825                 830         


Glu Phe Thr Val Gly Asn Thr Ala Ala Lys Tyr Phe Phe Asp Ala Val 
        835                 840                 845             


Glu Arg Tyr Cys Lys Glu Asn Glu Thr Gly Pro Tyr Lys Asn Pro Ala 
    850                 855                 860                 


Lys Ser Phe Asn Asp Tyr Val Asn Gly Ala Phe Asn Asn Lys Gly Val 
865                 870                 875                 880 


Lys Val Gln Lys Gly Leu Ser Asp Leu Tyr Arg Glu Gly Lys Ile Thr 
                885                 890                 895     


Phe Gly Val Val Cys Gln Thr Ile Met Ala Glu Tyr Thr Gln Gln Asn 
            900                 905                 910         


Glu Lys Ser Glu Gly Glu Ala Ile Tyr Gln His Phe Lys Met Leu Phe 
        915                 920                 925             


Pro Leu Cys Met Arg Lys Gly Phe Gln Lys Tyr Val Glu Glu Lys His 
    930                 935                 940                 


Lys Glu Leu Leu Gln Pro Val Ile Arg Glu Met Gly Ser Arg Glu Asp 
945                 950                 955                 960 


Phe Leu Thr Asn Ile His Ile Gly Cys Phe Asp Asp Phe Cys Arg Glu 
                965                 970                 975     


Asp Gly Met Tyr Glu Tyr Asp Trp Phe Val Val Ala His Leu Ile His 
            980                 985                 990         


Pro Lys Arg Leu Asn Glu Leu Val  Gly Asn Leu Lys Asp  Tyr Met Gln 
        995                 1000                 1005             


Phe Lys  Gln Asp Ile Leu Arg  Arg Ala Asp Tyr Val  Glu Gln Phe 
    1010                 1015                 1020             


Thr Lys  Glu Glu Leu Ala Ala  Met Lys Ala Arg Thr  Glu Glu Lys 
    1025                 1030                 1035             


Leu Gln  Lys Ile Ser Gly Ile  Leu Arg Val Ala Glu  Phe Val Arg 
    1040                 1045                 1050             


Gly Ile  Ala Gly Arg Val Ser  Asn Thr Phe Ser Asp  Tyr Tyr Glu 
    1055                 1060                 1065             


Ser Glu  Glu Ala Tyr Ala Ser  Tyr Leu Glu Gln Tyr  Ile Glu Phe 
    1070                 1075                 1080             


Pro Arg  Ile Lys Gly Ser Thr  Val Phe Glu Ser Phe  Arg Asp Phe 
    1085                 1090                 1095             


Cys Val  Asn Thr Leu Pro Gly  Gly Ala Val Met Asp  Val Tyr Met 
    1100                 1105                 1110             


Asp Glu  Lys Asn Pro Arg Ile  Leu Arg Asn Val Glu  Val Ala Arg 
    1115                 1120                 1125             


Met Tyr  Ala Gly Gly Asp Ile  Gly Leu Arg Thr Arg  Lys Lys Val 
    1130                 1135                 1140             


Thr Ala  Glu Glu Leu Lys Arg  Tyr Tyr Gln Asn Glu  Ala Glu Val 
    1145                 1150                 1155             


Ala Ala  Leu Leu Lys Ala Gly  Leu Cys Ala Thr Ala  Glu Asp Gln 
    1160                 1165                 1170             


Lys Arg  Val Lys Ala Gln Gln  Glu Leu Arg Asn Arg  Ile Thr Leu 
    1175                 1180                 1185             


Thr Asp  Val Thr Glu Ile Gln  Glu Val Ile Asn Asp  Leu Leu Ser 
    1190                 1195                 1200             


Gln Leu  Val Thr Phe Ser Tyr  Phe Arg Glu Arg Asp  Glu Met Tyr 
    1205                 1210                 1215             


Leu Leu  Leu Gly Phe Tyr Tyr  Met Ala Leu Gln Ser  Asp Gly Asp 
    1220                 1225                 1230             


Trp Gly  Glu Glu Leu Arg Val  Phe Asp Gly Lys Lys  Leu Gln Val 
    1235                 1240                 1245             


Glu Asn  Gly Phe Val Leu Tyr  Gln Leu Leu Ser Ala  Phe Thr Tyr 
    1250                 1255                 1260             


Gly Leu  Asn Met Tyr Ser Glu  Ala Ala Pro Asp Gly  Lys Gly Gly 
    1265                 1270                 1275             


Ser Gln  Ala Gly Lys Ile Gly  Glu Phe Ile Lys Ala  His Pro Asn 
    1280                 1285                 1290             


Ser Trp  Asp Arg Ala Leu Arg  Leu Phe Val Asp Asp  Gly Ala Cys 
    1295                 1300                 1305             


Glu Glu  Val Ser Arg Lys Ala  Arg Asn Tyr Val Asp  His Phe Arg 
    1310                 1315                 1320             


Tyr Tyr  Val Lys Pro Asp Arg  Ser Ile Met Asp Leu  Tyr Ala Val 
    1325                 1330                 1335             


Tyr His  Glu Tyr Phe Phe Asp  Tyr Ser Thr Lys Met  Arg Lys Ser 
    1340                 1345                 1350             


Val Leu  Gln Asn Phe Ala Ser  Ile Leu Glu Arg Tyr  Phe Val Leu 
    1355                 1360                 1365             


Thr Lys  Phe Lys Leu Gly Gly  Glu Arg Gly Ala Gln  Thr Leu Glu 
    1370                 1375                 1380             


Ala Glu  Leu Ser Gly Asp Lys  Phe Thr Tyr Lys Leu  Ser Asp Thr 
    1385                 1390                 1395             


Lys Ala  Lys Pro Val Val Leu  Pro Ala Arg Asn Lys  Glu Phe Leu 
    1400                 1405                 1410             


Glu Asn  Leu Lys Asn Glu Leu  Asn Tyr Arg Gln Glu  
    1415                 1420                 1425 


<210>  381
<211>  1425
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  381

Met Lys Leu Ser Lys Val Asp Arg Ile Arg Val Ala Val Gly Lys Thr 
1               5                   10                  15      


Gly Lys Thr Glu Asn Gly Asn Ser Gln Gly Arg Gly Val Leu Tyr Arg 
            20                  25                  30          


Ser Pro Lys Gly Asn Lys Thr Val Ala Val Asp Ala Val Val Glu Glu 
        35                  40                  45              


Arg Ile Arg Asn Ala Asn Arg Leu Tyr Ser Ala Phe Phe Arg Cys Ala 
    50                  55                  60                  


Tyr Pro Glu Glu Pro Glu Arg His Phe Glu Glu Ile Ile Lys Arg Met 
65                  70                  75                  80  


Ala Thr Gly Lys Lys Ser Gly Ala Gln Ile Leu Lys Glu Tyr Ile Gly 
                85                  90                  95      


Tyr Glu Gly Gln Lys Asn Arg Lys Pro Tyr Thr Phe Tyr Val Asn Lys 
            100                 105                 110         


Cys Ala Tyr Arg Pro Ala Gly Lys Glu Leu Gly Gln Val Leu Arg Leu 
        115                 120                 125             


Phe Val Lys Glu Arg Leu Gly Gln Asn Trp Gln Asn Pro Glu Ala Ala 
    130                 135                 140                 


Glu Ala Ala Val Ala Leu Leu Thr Cys Leu Cys Glu Gly Lys Thr Asn 
145                 150                 155                 160 


Arg Tyr Thr Glu Asn Thr Ala Asp Gly Pro Val Leu Thr Glu Leu Ser 
                165                 170                 175     


Glu Gln Thr Val Thr Gln Leu Glu Gln Val Ser Arg Leu Gly Gly Ser 
            180                 185                 190         


Ile Leu Val Pro Lys Thr Glu Arg Leu Glu Thr Ile Val Thr Val Ile 
        195                 200                 205             


Leu Arg Leu Thr Ala Glu Gln Cys Asn Thr Ser Leu Tyr Val Asn Gly 
    210                 215                 220                 


Gly Thr Lys Glu Ala Gln Asp Ala Asp Leu Glu Lys Gln Ile Ala Leu 
225                 230                 235                 240 


Leu Lys Ser Leu Gln Thr Lys Pro Leu Leu Leu Lys Glu Arg Phe Asp 
                245                 250                 255     


Lys Val Thr Lys Gln Thr Ile Arg Asp Glu Gln Lys Leu Ser Glu Phe 
            260                 265                 270         


Ser Tyr Lys Asp Ala Thr Lys Glu Arg Met Glu Ala Val Val Val Arg 
        275                 280                 285             


Met Arg Lys Thr Leu Lys Lys Gly Ala Ser Arg Glu Val Ala Val Glu 
    290                 295                 300                 


Leu Leu Gln Ala Leu Ala Gln Tyr Asp Gly Lys Thr Trp Asp Gly Trp 
305                 310                 315                 320 


Leu Thr Gln Met Leu Glu Thr Glu Ala Ser Lys Lys Lys Leu Lys Asp 
                325                 330                 335     


Phe Ile Leu Ala Val Asn Lys Asp Phe His His Phe His Val Ile Lys 
            340                 345                 350         


Ser Val Lys Asn Thr Ala Val Ala Val Ser His Ser Glu Asp Asn Thr 
        355                 360                 365             


Leu Gln Leu Ser Gly Ala Lys Lys Lys Thr Lys Gly Ala Met Gln Asp 
    370                 375                 380                 


Ala Leu Phe Ala Tyr Ala Gln Ser Glu Glu Ser Ser Asp Glu Thr Leu 
385                 390                 395                 400 


His Arg Ile Lys Arg Ile Leu Phe Thr Tyr Val Leu Gly Gly Arg Gln 
                405                 410                 415     


Asp Asn Thr Leu Arg Leu Thr Glu Lys Thr His Leu Ala Lys Glu Leu 
            420                 425                 430         


Leu Trp Lys Phe Arg Gly Thr Gly Ala Gly Leu Phe Asp Ala Asp Phe 
        435                 440                 445             


Val Pro Glu Glu Glu Arg Ala Gly Glu Ser Gly Arg Lys Ala Gly Ser 
    450                 455                 460                 


Tyr Thr Asp Leu Gly Cys Leu Phe Ala Glu Asp Asp Gly Ile Arg Asn 
465                 470                 475                 480 


Gln Arg Arg Ile Ala Asp Arg Ile Asn Tyr Val Asn Tyr Gly Asn Tyr 
                485                 490                 495     


Leu Arg Met Arg Lys Ala Ala Glu Asp Glu Phe Thr Leu Phe Trp Cys 
            500                 505                 510         


Ala Tyr Ile Lys Asp Tyr Ile Glu Glu Asn Tyr Val Thr Lys Ile Arg 
        515                 520                 525             


Glu Ala Lys Arg Thr Gly Gly Lys Arg Arg Leu Lys Glu Thr Asp Cys 
    530                 535                 540                 


Glu Ala Glu Arg Met Met Glu Lys Cys Trp His Asp Ile Ile Arg Tyr 
545                 550                 555                 560 


Ile Cys Gly Lys Tyr Ile His Ile Gly Lys Ala Val Tyr His Phe Ala 
                565                 570                 575     


Ile Pro Glu Asp Leu Leu Ala Asn Pro Gly Glu Val Arg Ser Phe Gly 
            580                 585                 590         


Asp Val His Ala Lys Tyr Ala Asp Gly Ile Thr Ser Phe Asp Tyr Glu 
        595                 600                 605             


Asp Ile Lys Ala Glu Glu Asn Leu Gln Lys Ser Ile Phe Asn Val Leu 
    610                 615                 620                 


Val Ser Ala Val Ala Asn Tyr Ser Arg Ser Val Val Asp Leu Ser Ser 
625                 630                 635                 640 


Glu Arg Ala Glu Glu Leu Arg Arg Leu Pro Gly Asn Glu Arg Leu Asn 
                645                 650                 655     


Glu Asp Val Leu Met Met Lys Glu Thr His Leu Lys Glu Leu Leu Leu 
            660                 665                 670         


Pro Asp Ala Lys Lys Arg Leu Leu Arg Tyr Phe Gly Gly Tyr Ser Ala 
        675                 680                 685             


Cys Glu Gly Leu Ser Gly Val Thr Ser Glu Glu Leu Ala Trp Glu Met 
    690                 695                 700                 


Arg Thr Val Leu Ser Thr Leu Arg Asn Glu Ser Phe His Tyr Thr Phe 
705                 710                 715                 720 


Gly Lys Lys Lys Lys Leu Asp Tyr Lys Val Ala Lys Gln Leu Trp Met 
                725                 730                 735     


Gln Ala Ile Arg Ala Asn Arg Gln Leu Ile Leu Asp Lys Tyr Tyr Ser 
            740                 745                 750         


Asn Asn Thr Cys Arg Tyr Tyr Ser Pro Asn Ser Ile Lys Ala Leu Ile 
        755                 760                 765             


Glu Gln Gly Tyr Arg Ser Tyr Glu Glu Arg Glu Ala Gln Ile Pro Ala 
    770                 775                 780                 


Phe Lys Thr Val Trp Lys Lys Ala Glu Leu Ala Lys Tyr Leu Ala Asp 
785                 790                 795                 800 


Lys Lys Val Met Pro Ala Glu Ile Ser Gly Glu Glu Lys Glu Arg Val 
                805                 810                 815     


Ile Phe Gln Gly Ala Phe Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg 
            820                 825                 830         


Glu Phe Thr Val Gly Asn Thr Ala Ala Lys Tyr Phe Phe Asp Ala Val 
        835                 840                 845             


Glu Arg Tyr Cys Lys Glu Asn Glu Thr Gly Pro Tyr Lys Asn Pro Ala 
    850                 855                 860                 


Lys Ser Phe Asn Asp Tyr Val Asn Gly Ala Phe Asn Asn Lys Gly Val 
865                 870                 875                 880 


Lys Val Gln Lys Gly Leu Ser Asp Leu Tyr Arg Glu Gly Lys Ile Thr 
                885                 890                 895     


Phe Gly Val Val Cys Gln Thr Ile Met Ala Glu Tyr Thr Gln Gln Asn 
            900                 905                 910         


Glu Lys Ser Glu Gly Glu Ala Ile Tyr Gln His Phe Lys Met Leu Phe 
        915                 920                 925             


Pro Leu Cys Met Arg Lys Gly Phe Gln Lys Tyr Val Glu Glu Lys His 
    930                 935                 940                 


Lys Glu Leu Leu Gln Pro Val Ile Arg Glu Met Gly Ser Arg Glu Asp 
945                 950                 955                 960 


Phe Leu Thr Asn Ile His Ile Gly Cys Phe Asp Asp Phe Cys Arg Glu 
                965                 970                 975     


Asp Gly Met Tyr Glu Tyr Asp Trp Phe Val Val Ala His Leu Ile His 
            980                 985                 990         


Pro Lys Arg Leu Asn Glu Leu Val  Gly Asn Leu Lys Asp  Tyr Met Gln 
        995                 1000                 1005             


Phe Lys  Gln Asp Ile Leu Arg  Arg Ala Asp Tyr Val  Glu Gln Phe 
    1010                 1015                 1020             


Thr Lys  Glu Glu Leu Ala Ala  Met Lys Ala Arg Thr  Glu Glu Lys 
    1025                 1030                 1035             


Leu Gln  Lys Ile Ser Gly Ile  Leu Arg Val Ala Glu  Phe Val Arg 
    1040                 1045                 1050             


Gly Ile  Ala Gly Arg Val Ser  Asn Thr Phe Ser Asp  Tyr Tyr Glu 
    1055                 1060                 1065             


Ser Glu  Glu Ala Tyr Ala Ser  Tyr Leu Glu Gln Tyr  Ile Glu Phe 
    1070                 1075                 1080             


Pro Arg  Ile Lys Gly Ser Thr  Val Phe Glu Ser Phe  Arg Asp Phe 
    1085                 1090                 1095             


Cys Val  Asn Thr Leu Pro Gly  Gly Ala Val Met Asp  Val Tyr Met 
    1100                 1105                 1110             


Asp Glu  Lys Asn Pro Arg Ile  Leu Arg Asn Val Glu  Val Ala Arg 
    1115                 1120                 1125             


Met Tyr  Ala Gly Gly Asp Ile  Gly Leu Arg Thr Arg  Lys Lys Val 
    1130                 1135                 1140             


Thr Ala  Glu Glu Leu Lys Arg  Tyr Tyr Gln Asn Glu  Ala Glu Val 
    1145                 1150                 1155             


Ala Ala  Leu Leu Lys Ala Gly  Leu Cys Ala Thr Ala  Glu Asp Gln 
    1160                 1165                 1170             


Lys Arg  Val Lys Ala Gln Gln  Glu Leu Arg Asn Arg  Ile Thr Leu 
    1175                 1180                 1185             


Thr Asp  Val Thr Glu Ile Gln  Glu Val Ile Asn Asp  Leu Leu Ser 
    1190                 1195                 1200             


Gln Leu  Val Thr Phe Ser Tyr  Phe Arg Glu Arg Asp  Glu Met Tyr 
    1205                 1210                 1215             


Leu Leu  Leu Gly Phe Tyr Tyr  Met Ala Leu Gln Ser  Asp Gly Asp 
    1220                 1225                 1230             


Trp Gly  Glu Glu Leu Arg Val  Phe Asp Gly Lys Lys  Leu Gln Val 
    1235                 1240                 1245             


Glu Asn  Gly Phe Val Leu Tyr  Gln Leu Leu Ser Ala  Phe Thr Tyr 
    1250                 1255                 1260             


Gly Leu  Asn Met Tyr Ser Glu  Ala Ala Pro Asp Gly  Lys Gly Gly 
    1265                 1270                 1275             


Ser Gln  Ala Gly Lys Ile Gly  Glu Phe Ile Lys Ala  His Pro Asn 
    1280                 1285                 1290             


Ser Trp  Asp Arg Ala Leu Arg  Leu Phe Val Asp Asp  Gly Ala Cys 
    1295                 1300                 1305             


Glu Glu  Val Ser Arg Lys Ala  Arg Asn Tyr Val Asp  His Phe Arg 
    1310                 1315                 1320             


Tyr Tyr  Val Lys Pro Asp Arg  Ser Ile Met Asp Leu  Tyr Ala Val 
    1325                 1330                 1335             


Tyr His  Glu Tyr Phe Phe Asp  Tyr Ser Thr Lys Met  Arg Lys Ser 
    1340                 1345                 1350             


Val Leu  Gln Asn Phe Ala Ser  Ile Leu Glu Arg Tyr  Phe Val Leu 
    1355                 1360                 1365             


Thr Lys  Phe Lys Leu Gly Gly  Glu Arg Gly Ala Gln  Thr Leu Glu 
    1370                 1375                 1380             


Ala Glu  Leu Ser Gly Asp Lys  Phe Thr Tyr Lys Leu  Ser Asp Thr 
    1385                 1390                 1395             


Lys Ala  Lys Pro Val Val Leu  Pro Ala Arg Asn Lys  Glu Phe Leu 
    1400                 1405                 1410             


Glu Asn  Leu Lys Asn Glu Leu  Asn Tyr Arg Gln Glu  
    1415                 1420                 1425 


<210>  382
<211>  1425
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  382

Met Lys Leu Ser Lys Val Asp Arg Ile Arg Val Ala Val Gly Lys Thr 
1               5                   10                  15      


Gly Lys Thr Glu Asn Gly Asn Ser Gln Gly Arg Gly Val Leu Tyr Arg 
            20                  25                  30          


Ser Pro Lys Gly Asn Lys Thr Val Ala Val Asp Ala Val Val Glu Glu 
        35                  40                  45              


Arg Ile Arg Asn Ala Asn Arg Leu Tyr Ser Ala Phe Phe Arg Cys Ala 
    50                  55                  60                  


Tyr Pro Glu Glu Pro Glu Arg His Phe Glu Glu Ile Ile Lys Arg Met 
65                  70                  75                  80  


Ala Thr Gly Lys Lys Ser Gly Ala Gln Ile Leu Lys Glu Tyr Ile Gly 
                85                  90                  95      


Tyr Glu Gly Gln Lys Asn Arg Lys Pro Tyr Thr Phe Tyr Val Asn Lys 
            100                 105                 110         


Cys Ala Tyr Arg Pro Ala Gly Lys Glu Leu Gly Gln Val Leu Arg Leu 
        115                 120                 125             


Phe Val Lys Glu Arg Leu Gly Gln Asn Trp Gln Asn Pro Glu Ala Ala 
    130                 135                 140                 


Glu Ala Ala Val Ala Leu Leu Thr Cys Leu Cys Glu Gly Lys Thr Asn 
145                 150                 155                 160 


Arg Tyr Thr Glu Asn Thr Ala Asp Gly Pro Val Leu Thr Glu Leu Ser 
                165                 170                 175     


Glu Gln Thr Val Thr Gln Leu Glu Gln Val Ser Arg Leu Gly Gly Ser 
            180                 185                 190         


Ile Leu Val Pro Lys Thr Glu Arg Leu Glu Thr Ile Val Thr Val Ile 
        195                 200                 205             


Leu Arg Leu Thr Ala Glu Gln Cys Asn Thr Ser Leu Tyr Val Asn Gly 
    210                 215                 220                 


Gly Thr Lys Glu Ala Gln Asp Ala Asp Leu Glu Lys Gln Ile Ala Leu 
225                 230                 235                 240 


Leu Lys Ser Leu Gln Thr Lys Pro Leu Leu Leu Lys Glu Arg Phe Asp 
                245                 250                 255     


Lys Val Thr Lys Gln Thr Ile Arg Asp Glu Gln Lys Leu Ser Glu Phe 
            260                 265                 270         


Ser Tyr Lys Asp Ala Thr Lys Glu Arg Met Glu Ala Val Val Val Arg 
        275                 280                 285             


Met Arg Lys Thr Leu Lys Lys Gly Ala Ser Arg Glu Val Ala Val Glu 
    290                 295                 300                 


Leu Leu Gln Ala Leu Ala Gln Tyr Asp Gly Lys Thr Trp Asp Gly Trp 
305                 310                 315                 320 


Leu Thr Gln Met Leu Glu Thr Glu Ala Ser Lys Lys Lys Leu Lys Asp 
                325                 330                 335     


Phe Ile Leu Ala Val Asn Lys Asp Phe His His Phe His Val Ile Lys 
            340                 345                 350         


Ser Val Lys Asn Thr Ala Val Ala Val Ser His Ser Glu Asp Asn Thr 
        355                 360                 365             


Leu Gln Leu Ser Gly Ala Lys Lys Lys Thr Lys Gly Ala Met Gln Asp 
    370                 375                 380                 


Ala Leu Phe Ala Tyr Ala Gln Ser Glu Glu Ser Ser Asp Glu Thr Leu 
385                 390                 395                 400 


His Arg Ile Lys Arg Ile Leu Phe Thr Tyr Val Leu Gly Gly Arg Gln 
                405                 410                 415     


Asp Asn Thr Leu Arg Leu Thr Glu Lys Thr His Leu Ala Lys Glu Leu 
            420                 425                 430         


Leu Trp Lys Phe Arg Gly Thr Gly Ala Gly Leu Phe Asp Ala Asp Phe 
        435                 440                 445             


Val Pro Glu Glu Glu Arg Ala Gly Glu Ser Gly Arg Lys Ala Gly Ser 
    450                 455                 460                 


Tyr Thr Asp Leu Gly Cys Leu Phe Ala Glu Asp Asp Gly Ile Arg Asn 
465                 470                 475                 480 


Gln Arg Arg Ile Ala Asp Arg Ile Asn Tyr Val Asn Tyr Gly Asn Tyr 
                485                 490                 495     


Leu Arg Met Arg Lys Ala Ala Glu Asp Glu Phe Thr Leu Phe Trp Cys 
            500                 505                 510         


Ala Tyr Ile Lys Asp Tyr Ile Glu Glu Asn Tyr Val Thr Lys Ile Arg 
        515                 520                 525             


Glu Ala Lys Arg Thr Gly Gly Lys Arg Arg Leu Lys Glu Thr Asp Cys 
    530                 535                 540                 


Glu Ala Glu Arg Met Met Glu Lys Cys Trp His Asp Ile Ile Arg Tyr 
545                 550                 555                 560 


Ile Cys Gly Lys Tyr Ile His Ile Gly Lys Ala Val Tyr His Phe Ala 
                565                 570                 575     


Ile Pro Glu Asp Leu Leu Ala Asn Pro Gly Glu Val Arg Ser Phe Gly 
            580                 585                 590         


Asp Val His Ala Lys Tyr Ala Asp Gly Ile Thr Ser Phe Asp Tyr Glu 
        595                 600                 605             


Asp Ile Lys Ala Glu Glu Asn Leu Gln Lys Ser Ile Phe Asn Val Leu 
    610                 615                 620                 


Val Ser Ala Val Ala Asn Tyr Ser Arg Ser Val Val Asp Leu Ser Ser 
625                 630                 635                 640 


Glu Arg Ala Glu Glu Leu Arg Arg Leu Pro Gly Asn Glu Arg Leu Asn 
                645                 650                 655     


Glu Asp Val Leu Met Met Lys Glu Thr His Leu Lys Glu Leu Leu Leu 
            660                 665                 670         


Pro Asp Ala Lys Lys Arg Leu Leu Arg Tyr Phe Gly Gly Tyr Ser Ala 
        675                 680                 685             


Cys Glu Gly Leu Ser Gly Val Thr Ser Glu Glu Leu Ala Trp Glu Met 
    690                 695                 700                 


Arg Thr Val Leu Ser Thr Leu Arg Asn Glu Ser Phe His Tyr Thr Phe 
705                 710                 715                 720 


Gly Lys Lys Lys Lys Leu Asp Tyr Lys Val Ala Lys Gln Leu Trp Met 
                725                 730                 735     


Gln Ala Ile Arg Ala Asn Arg Gln Leu Ile Leu Asp Lys Tyr Tyr Ser 
            740                 745                 750         


Asn Asn Thr Cys Arg Tyr Tyr Ser Pro Asn Ser Ile Lys Ala Leu Ile 
        755                 760                 765             


Glu Gln Gly Tyr Arg Ser Tyr Glu Glu Arg Glu Ala Gln Ile Pro Ala 
    770                 775                 780                 


Phe Lys Thr Val Trp Lys Lys Ala Glu Leu Ala Lys Tyr Leu Ala Asp 
785                 790                 795                 800 


Lys Lys Val Met Pro Ala Glu Ile Ser Gly Glu Glu Lys Glu Arg Val 
                805                 810                 815     


Ile Phe Gln Gly Ala Phe Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg 
            820                 825                 830         


Glu Phe Thr Val Gly Asn Thr Ala Ala Lys Tyr Phe Phe Asp Ala Val 
        835                 840                 845             


Glu Arg Tyr Cys Lys Glu Asn Glu Thr Gly Pro Tyr Lys Asn Pro Ala 
    850                 855                 860                 


Lys Ser Phe Asn Asp Tyr Val Asn Gly Ala Phe Asn Asn Lys Gly Val 
865                 870                 875                 880 


Lys Val Gln Lys Gly Leu Ser Asp Leu Tyr Arg Glu Gly Lys Ile Thr 
                885                 890                 895     


Phe Gly Val Val Cys Gln Thr Ile Met Ala Glu Tyr Thr Gln Gln Asn 
            900                 905                 910         


Glu Lys Ser Glu Gly Glu Ala Ile Tyr Gln His Phe Lys Met Leu Phe 
        915                 920                 925             


Pro Leu Cys Met Arg Lys Gly Phe Gln Lys Tyr Val Glu Glu Lys His 
    930                 935                 940                 


Lys Glu Leu Leu Gln Pro Val Ile Arg Glu Met Gly Ser Arg Glu Asp 
945                 950                 955                 960 


Phe Leu Thr Asn Ile His Ile Gly Cys Phe Asp Asp Phe Cys Arg Glu 
                965                 970                 975     


Asp Gly Met Tyr Glu Tyr Asp Trp Phe Val Val Ala His Leu Ile His 
            980                 985                 990         


Pro Lys Arg Leu Asn Glu Leu Val  Gly Asn Leu Lys Asp  Tyr Met Gln 
        995                 1000                 1005             


Phe Lys  Gln Asp Ile Leu Arg  Arg Ala Asp Tyr Val  Glu Gln Phe 
    1010                 1015                 1020             


Thr Lys  Glu Glu Leu Ala Ala  Met Lys Ala Arg Thr  Glu Glu Lys 
    1025                 1030                 1035             


Leu Gln  Lys Ile Ser Gly Ile  Leu Arg Val Ala Glu  Phe Val Arg 
    1040                 1045                 1050             


Gly Ile  Ala Gly Arg Val Ser  Asn Thr Phe Ser Asp  Tyr Tyr Glu 
    1055                 1060                 1065             


Ser Glu  Glu Ala Tyr Ala Ser  Tyr Leu Glu Gln Tyr  Ile Glu Phe 
    1070                 1075                 1080             


Pro Arg  Ile Lys Gly Ser Thr  Val Phe Glu Ser Phe  Arg Asp Phe 
    1085                 1090                 1095             


Cys Val  Asn Thr Leu Pro Gly  Gly Ala Val Met Asp  Val Tyr Met 
    1100                 1105                 1110             


Asp Glu  Lys Asn Pro Arg Ile  Leu Arg Asn Val Glu  Val Ala Arg 
    1115                 1120                 1125             


Met Tyr  Ala Gly Gly Asp Ile  Gly Leu Arg Thr Arg  Lys Lys Val 
    1130                 1135                 1140             


Thr Ala  Glu Glu Leu Lys Arg  Tyr Tyr Gln Asn Glu  Ala Glu Val 
    1145                 1150                 1155             


Ala Ala  Leu Leu Lys Ala Gly  Leu Cys Ala Thr Ala  Glu Asp Gln 
    1160                 1165                 1170             


Lys Arg  Val Lys Ala Gln Gln  Glu Leu Arg Asn Arg  Ile Thr Leu 
    1175                 1180                 1185             


Thr Asp  Val Thr Glu Ile Gln  Glu Val Ile Asn Asp  Leu Leu Ser 
    1190                 1195                 1200             


Gln Leu  Val Thr Phe Ser Tyr  Phe Arg Glu Arg Asp  Glu Met Tyr 
    1205                 1210                 1215             


Leu Leu  Leu Gly Phe Tyr Tyr  Met Ala Leu Gln Ser  Asp Gly Asp 
    1220                 1225                 1230             


Trp Gly  Glu Glu Leu Arg Val  Phe Asp Gly Lys Lys  Leu Gln Val 
    1235                 1240                 1245             


Glu Asn  Gly Phe Val Leu Tyr  Gln Leu Leu Ser Ala  Phe Thr Tyr 
    1250                 1255                 1260             


Gly Leu  Asn Met Tyr Ser Glu  Ala Ala Pro Asp Gly  Lys Gly Gly 
    1265                 1270                 1275             


Ser Gln  Ala Gly Lys Ile Gly  Glu Phe Ile Lys Ala  His Pro Asn 
    1280                 1285                 1290             


Ser Trp  Asp Arg Ala Leu Arg  Leu Phe Val Asp Asp  Gly Ala Cys 
    1295                 1300                 1305             


Glu Glu  Val Ser Arg Lys Ala  Arg Asn Tyr Val Asp  His Phe Arg 
    1310                 1315                 1320             


Tyr Tyr  Val Lys Pro Asp Arg  Ser Ile Met Asp Leu  Tyr Ala Val 
    1325                 1330                 1335             


Tyr His  Glu Tyr Phe Phe Asp  Tyr Ser Thr Lys Met  Arg Lys Ser 
    1340                 1345                 1350             


Val Leu  Gln Asn Phe Ala Ser  Ile Leu Glu Arg Tyr  Phe Val Leu 
    1355                 1360                 1365             


Thr Lys  Phe Lys Leu Gly Gly  Glu Arg Gly Ala Gln  Thr Leu Glu 
    1370                 1375                 1380             


Ala Glu  Leu Ser Gly Asp Lys  Phe Thr Tyr Lys Leu  Ser Asp Thr 
    1385                 1390                 1395             


Lys Ala  Lys Pro Val Val Leu  Pro Ala Arg Asn Lys  Glu Phe Leu 
    1400                 1405                 1410             


Glu Asn  Leu Lys Asn Glu Leu  Asn Tyr Arg Gln Glu  
    1415                 1420                 1425 


<210>  383
<211>  1425
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  383

Met Lys Leu Ser Lys Val Asp Arg Ile Arg Val Ala Val Gly Lys Thr 
1               5                   10                  15      


Gly Lys Thr Glu Asn Gly Asn Ser Gln Gly Arg Gly Val Leu Tyr Arg 
            20                  25                  30          


Ser Pro Lys Gly Asn Lys Thr Val Ala Val Asp Ala Val Val Glu Glu 
        35                  40                  45              


Arg Ile Arg Asn Ala Asn Arg Leu Tyr Ser Ala Phe Phe Arg Cys Ala 
    50                  55                  60                  


Tyr Pro Glu Glu Pro Glu Arg His Phe Glu Glu Ile Ile Lys Arg Met 
65                  70                  75                  80  


Ala Thr Gly Lys Lys Ser Gly Ala Gln Ile Leu Lys Glu Tyr Ile Gly 
                85                  90                  95      


Tyr Glu Gly Gln Lys Asn Arg Lys Pro Tyr Thr Phe Tyr Val Asn Lys 
            100                 105                 110         


Cys Ala Tyr Arg Pro Ala Gly Lys Glu Leu Gly Gln Val Leu Arg Leu 
        115                 120                 125             


Phe Val Lys Glu Arg Leu Gly Gln Asn Trp Gln Asn Pro Glu Ala Ala 
    130                 135                 140                 


Glu Ala Ala Val Ala Leu Leu Thr Cys Leu Cys Glu Gly Lys Thr Asn 
145                 150                 155                 160 


Arg Tyr Thr Glu Asn Thr Ala Asp Gly Pro Val Leu Thr Glu Leu Ser 
                165                 170                 175     


Glu Gln Thr Val Thr Gln Leu Glu Gln Val Ser Arg Leu Gly Gly Ser 
            180                 185                 190         


Ile Leu Val Pro Lys Thr Glu Arg Leu Glu Thr Ile Val Thr Val Ile 
        195                 200                 205             


Leu Arg Leu Thr Ala Glu Gln Cys Asn Thr Ser Leu Tyr Val Asn Gly 
    210                 215                 220                 


Gly Thr Lys Glu Ala Gln Asp Ala Asp Leu Glu Lys Gln Ile Ala Leu 
225                 230                 235                 240 


Leu Lys Ser Leu Gln Thr Lys Pro Leu Leu Leu Lys Glu Arg Phe Asp 
                245                 250                 255     


Lys Val Thr Lys Gln Thr Ile Arg Asp Glu Gln Lys Leu Ser Glu Phe 
            260                 265                 270         


Ser Tyr Lys Asp Ala Thr Lys Glu Arg Met Glu Ala Val Val Val Arg 
        275                 280                 285             


Met Arg Lys Thr Leu Lys Lys Gly Ala Ser Arg Glu Val Ala Val Glu 
    290                 295                 300                 


Leu Leu Gln Ala Leu Ala Gln Tyr Asp Gly Lys Thr Trp Asp Gly Trp 
305                 310                 315                 320 


Leu Thr Gln Met Leu Glu Thr Glu Ala Ser Lys Lys Lys Leu Lys Asp 
                325                 330                 335     


Phe Ile Leu Ala Val Asn Lys Asp Phe His His Phe His Val Ile Lys 
            340                 345                 350         


Ser Val Lys Asn Thr Ala Val Ala Val Ser His Ser Glu Asp Asn Thr 
        355                 360                 365             


Leu Gln Leu Ser Gly Ala Lys Lys Lys Thr Lys Gly Ala Met Gln Asp 
    370                 375                 380                 


Ala Leu Phe Ala Tyr Ala Gln Ser Glu Glu Ser Ser Asp Glu Thr Leu 
385                 390                 395                 400 


His Arg Ile Lys Arg Ile Leu Phe Thr Tyr Val Leu Gly Gly Arg Gln 
                405                 410                 415     


Asp Asn Thr Leu Arg Leu Thr Glu Lys Thr His Leu Ala Lys Glu Leu 
            420                 425                 430         


Leu Trp Lys Phe Arg Gly Thr Gly Ala Gly Leu Phe Asp Ala Asp Phe 
        435                 440                 445             


Val Pro Glu Glu Glu Arg Ala Gly Glu Ser Gly Arg Lys Ala Gly Ser 
    450                 455                 460                 


Tyr Thr Asp Leu Gly Cys Leu Phe Ala Glu Asp Asp Gly Ile Arg Asn 
465                 470                 475                 480 


Gln Arg Arg Ile Ala Asp Arg Ile Asn Tyr Val Asn Tyr Gly Asn Tyr 
                485                 490                 495     


Leu Arg Met Arg Lys Ala Ala Glu Asp Glu Phe Thr Leu Phe Trp Cys 
            500                 505                 510         


Ala Tyr Ile Lys Asp Tyr Ile Glu Glu Asn Tyr Val Thr Lys Ile Arg 
        515                 520                 525             


Glu Ala Lys Arg Thr Gly Gly Lys Arg Arg Leu Lys Glu Thr Asp Cys 
    530                 535                 540                 


Glu Ala Glu Arg Met Met Glu Lys Cys Trp His Asp Ile Ile Arg Tyr 
545                 550                 555                 560 


Ile Cys Gly Lys Tyr Ile His Ile Gly Lys Ala Val Tyr His Phe Ala 
                565                 570                 575     


Ile Pro Glu Asp Leu Leu Ala Asn Pro Gly Glu Val Arg Ser Phe Gly 
            580                 585                 590         


Asp Val His Ala Lys Tyr Ala Asp Gly Ile Thr Ser Phe Asp Tyr Glu 
        595                 600                 605             


Asp Ile Lys Ala Glu Glu Asn Leu Gln Lys Ser Ile Phe Asn Val Leu 
    610                 615                 620                 


Val Ser Ala Val Ala Asn Tyr Ser Arg Ser Val Val Asp Leu Ser Ser 
625                 630                 635                 640 


Glu Arg Ala Glu Glu Leu Arg Arg Leu Pro Gly Asn Glu Arg Leu Asn 
                645                 650                 655     


Glu Asp Val Leu Met Met Lys Glu Thr His Leu Lys Glu Leu Leu Leu 
            660                 665                 670         


Pro Asp Ala Lys Lys Arg Leu Leu Arg Tyr Phe Gly Gly Tyr Ser Ala 
        675                 680                 685             


Cys Glu Gly Leu Ser Gly Val Thr Ser Glu Glu Leu Ala Trp Glu Met 
    690                 695                 700                 


Arg Thr Val Leu Ser Thr Leu Arg Asn Glu Ser Phe His Tyr Thr Phe 
705                 710                 715                 720 


Gly Lys Lys Lys Lys Leu Asp Tyr Lys Val Ala Lys Gln Leu Trp Met 
                725                 730                 735     


Gln Ala Ile Arg Ala Asn Arg Gln Leu Ile Leu Asp Lys Tyr Tyr Ser 
            740                 745                 750         


Asn Asn Thr Cys Arg Tyr Tyr Ser Pro Asn Ser Ile Lys Ala Leu Ile 
        755                 760                 765             


Glu Gln Gly Tyr Arg Ser Tyr Glu Glu Arg Glu Ala Gln Ile Pro Ala 
    770                 775                 780                 


Phe Lys Thr Val Trp Lys Lys Ala Glu Leu Ala Lys Tyr Leu Ala Asp 
785                 790                 795                 800 


Lys Lys Val Met Pro Ala Glu Ile Ser Gly Glu Glu Lys Glu Arg Val 
                805                 810                 815     


Ile Phe Gln Gly Ala Phe Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg 
            820                 825                 830         


Glu Phe Thr Val Gly Asn Thr Ala Ala Lys Tyr Phe Phe Asp Ala Val 
        835                 840                 845             


Glu Arg Tyr Cys Lys Glu Asn Glu Thr Gly Pro Tyr Lys Asn Pro Ala 
    850                 855                 860                 


Lys Ser Phe Asn Asp Tyr Val Asn Gly Ala Phe Asn Asn Lys Gly Val 
865                 870                 875                 880 


Lys Val Gln Lys Gly Leu Ser Asp Leu Tyr Arg Glu Gly Lys Ile Thr 
                885                 890                 895     


Phe Gly Val Val Cys Gln Thr Ile Met Ala Glu Tyr Thr Gln Gln Asn 
            900                 905                 910         


Glu Lys Ser Glu Gly Glu Ala Ile Tyr Gln His Phe Lys Met Leu Phe 
        915                 920                 925             


Pro Leu Cys Met Arg Lys Gly Phe Gln Lys Tyr Val Glu Glu Lys His 
    930                 935                 940                 


Lys Glu Leu Leu Gln Pro Val Ile Arg Glu Met Gly Ser Arg Glu Asp 
945                 950                 955                 960 


Phe Leu Thr Asn Ile His Ile Gly Cys Phe Asp Asp Phe Cys Arg Glu 
                965                 970                 975     


Asp Gly Met Tyr Glu Tyr Asp Trp Phe Val Val Ala His Leu Ile His 
            980                 985                 990         


Pro Lys Arg Leu Asn Glu Leu Val  Gly Asn Leu Lys Asp  Tyr Met Gln 
        995                 1000                 1005             


Phe Lys  Gln Asp Ile Leu Arg  Arg Ala Asp Tyr Val  Glu Gln Phe 
    1010                 1015                 1020             


Thr Lys  Glu Glu Leu Ala Ala  Met Lys Ala Arg Thr  Glu Glu Lys 
    1025                 1030                 1035             


Leu Gln  Lys Ile Ser Gly Ile  Leu Arg Val Ala Glu  Phe Val Arg 
    1040                 1045                 1050             


Gly Ile  Ala Gly Arg Val Ser  Asn Thr Phe Ser Asp  Tyr Tyr Glu 
    1055                 1060                 1065             


Ser Glu  Glu Ala Tyr Ala Ser  Tyr Leu Glu Gln Tyr  Ile Glu Phe 
    1070                 1075                 1080             


Pro Arg  Ile Lys Gly Ser Thr  Val Phe Glu Ser Phe  Arg Asp Phe 
    1085                 1090                 1095             


Cys Val  Asn Thr Leu Pro Gly  Gly Ala Val Met Asp  Val Tyr Met 
    1100                 1105                 1110             


Asp Glu  Lys Asn Pro Arg Ile  Leu Arg Asn Val Glu  Val Ala Arg 
    1115                 1120                 1125             


Met Tyr  Ala Gly Gly Asp Ile  Gly Leu Arg Thr Arg  Lys Lys Val 
    1130                 1135                 1140             


Thr Ala  Glu Glu Leu Lys Arg  Tyr Tyr Gln Asn Glu  Ala Glu Val 
    1145                 1150                 1155             


Ala Ala  Leu Leu Lys Ala Gly  Leu Cys Ala Thr Ala  Glu Asp Gln 
    1160                 1165                 1170             


Lys Arg  Val Lys Ala Gln Gln  Glu Leu Arg Asn Arg  Ile Thr Leu 
    1175                 1180                 1185             


Thr Asp  Val Thr Glu Ile Gln  Glu Val Ile Asn Asp  Leu Leu Ser 
    1190                 1195                 1200             


Gln Leu  Val Thr Phe Ser Tyr  Phe Arg Glu Arg Asp  Glu Met Tyr 
    1205                 1210                 1215             


Leu Leu  Leu Gly Phe Tyr Tyr  Met Ala Leu Gln Ser  Asp Gly Asp 
    1220                 1225                 1230             


Trp Gly  Glu Glu Leu Arg Val  Phe Asp Gly Lys Lys  Leu Gln Val 
    1235                 1240                 1245             


Glu Asn  Gly Phe Val Leu Tyr  Gln Leu Leu Ser Ala  Phe Thr Tyr 
    1250                 1255                 1260             


Gly Leu  Asn Met Tyr Ser Glu  Ala Ala Pro Asp Gly  Lys Gly Gly 
    1265                 1270                 1275             


Ser Gln  Ala Gly Lys Ile Gly  Glu Phe Ile Lys Ala  His Pro Asn 
    1280                 1285                 1290             


Ser Trp  Asp Arg Ala Leu Arg  Leu Phe Val Asp Asp  Gly Ala Cys 
    1295                 1300                 1305             


Glu Glu  Val Ser Arg Lys Ala  Arg Asn Tyr Val Asp  His Phe Arg 
    1310                 1315                 1320             


Tyr Tyr  Val Lys Pro Asp Arg  Ser Ile Met Asp Leu  Tyr Ala Val 
    1325                 1330                 1335             


Tyr His  Glu Tyr Phe Phe Asp  Tyr Ser Thr Lys Met  Arg Lys Ser 
    1340                 1345                 1350             


Val Leu  Gln Asn Phe Ala Ser  Ile Leu Glu Arg Tyr  Phe Val Leu 
    1355                 1360                 1365             


Thr Lys  Phe Lys Leu Gly Gly  Glu Arg Gly Ala Gln  Thr Leu Glu 
    1370                 1375                 1380             


Ala Glu  Leu Ser Gly Asp Lys  Phe Thr Tyr Lys Leu  Ser Asp Thr 
    1385                 1390                 1395             


Lys Ala  Lys Pro Val Val Leu  Pro Ala Arg Asn Lys  Glu Phe Leu 
    1400                 1405                 1410             


Glu Asn  Leu Lys Asn Glu Leu  Asn Tyr Arg Gln Glu  
    1415                 1420                 1425 


<210>  384
<211>  1389
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  384

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Lys Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn Gln Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Ile Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Asn Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Val Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Phe Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Gln Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Lys Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asp Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Val 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Met Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Cys Ile  Ser Ser Ile Lys Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Thr Leu Ile Thr Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Leu Leu Tyr  Tyr Pro Asp 
    1310                 1315                 1320             


Ile Glu  Ser Asn Val Lys Ile  Leu Leu Arg Lys Asp  Asn Phe Asn 
    1325                 1330                 1335             


Gln Asn  Lys Asp Lys Lys Asn  Val Asn Asn Arg Lys  Thr Lys Asn 
    1340                 1345                 1350             


Asn Asn  Lys Asn Gly Asn Arg  Asn Arg Asp Lys Asn  Arg Asp Lys 
    1355                 1360                 1365             


Asn Gly  Gly Gly Asp Gly Leu  Thr Tyr Asn Pro Phe  Leu Asn Leu 
    1370                 1375                 1380             


Ile Phe  Asp Leu Pro Glu 
    1385                 


<210>  385
<211>  1211
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  385

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Ser Asp Ser Gln Cys  Phe 
    1205                 1210     


<210>  386
<211>  1425
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  386

Met Lys Leu Ser Lys Val Asp Arg Ile Arg Val Ala Val Gly Lys Thr 
1               5                   10                  15      


Gly Lys Thr Glu Asn Gly Asn Ser Gln Gly Arg Gly Val Leu Tyr Arg 
            20                  25                  30          


Ser Pro Lys Gly Asn Lys Thr Val Ala Val Asp Ala Val Val Glu Glu 
        35                  40                  45              


Arg Ile Arg Asn Ala Asn Arg Leu Tyr Ser Ala Phe Phe Arg Cys Ala 
    50                  55                  60                  


Tyr Pro Glu Glu Pro Glu Arg His Phe Glu Glu Ile Ile Lys Arg Met 
65                  70                  75                  80  


Ala Thr Gly Lys Lys Ser Gly Ala Gln Ile Leu Lys Glu Tyr Ile Gly 
                85                  90                  95      


Tyr Glu Gly Gln Lys Asn Arg Lys Pro Tyr Thr Phe Tyr Val Asn Lys 
            100                 105                 110         


Cys Ala Tyr Arg Pro Ala Gly Lys Glu Leu Gly Gln Val Leu Arg Leu 
        115                 120                 125             


Phe Val Lys Glu Arg Leu Gly Gln Asn Trp Gln Asn Pro Glu Ala Ala 
    130                 135                 140                 


Glu Ala Ala Val Ala Leu Leu Thr Cys Leu Cys Glu Gly Lys Thr Asn 
145                 150                 155                 160 


Arg Tyr Thr Glu Asn Thr Ala Asp Gly Pro Val Leu Thr Glu Leu Ser 
                165                 170                 175     


Glu Gln Thr Val Thr Gln Leu Glu Gln Val Ser Arg Leu Gly Gly Ser 
            180                 185                 190         


Ile Leu Val Pro Lys Thr Glu Arg Leu Glu Thr Ile Val Thr Val Ile 
        195                 200                 205             


Leu Arg Leu Thr Ala Glu Gln Cys Asn Thr Ser Leu Tyr Val Asn Gly 
    210                 215                 220                 


Gly Thr Lys Glu Ala Gln Asp Ala Asp Leu Glu Lys Gln Ile Ala Leu 
225                 230                 235                 240 


Leu Lys Ser Leu Gln Thr Lys Pro Leu Leu Leu Lys Glu Arg Phe Asp 
                245                 250                 255     


Lys Val Thr Lys Gln Thr Ile Arg Asp Glu Gln Lys Leu Ser Glu Phe 
            260                 265                 270         


Ser Tyr Lys Asp Ala Thr Lys Glu Arg Met Glu Ala Val Val Val Arg 
        275                 280                 285             


Met Arg Lys Thr Leu Lys Lys Gly Ala Ser Arg Glu Val Ala Val Glu 
    290                 295                 300                 


Leu Leu Gln Ala Leu Ala Gln Tyr Asp Gly Lys Thr Trp Asp Gly Trp 
305                 310                 315                 320 


Leu Thr Gln Met Leu Glu Thr Glu Ala Ser Lys Lys Lys Leu Lys Asp 
                325                 330                 335     


Phe Ile Leu Ala Val Asn Lys Asp Phe His His Phe His Val Ile Lys 
            340                 345                 350         


Ser Val Lys Asn Thr Ala Val Ala Val Ser His Ser Glu Asp Asn Thr 
        355                 360                 365             


Leu Gln Leu Ser Gly Ala Lys Lys Lys Thr Lys Gly Ala Met Gln Asp 
    370                 375                 380                 


Ala Leu Phe Ala Tyr Ala Gln Ser Glu Glu Ser Ser Asp Glu Thr Leu 
385                 390                 395                 400 


His Arg Ile Lys Arg Ile Leu Phe Thr Tyr Val Leu Gly Gly Arg Gln 
                405                 410                 415     


Asp Asn Thr Leu Arg Leu Thr Glu Lys Thr His Leu Ala Lys Glu Leu 
            420                 425                 430         


Leu Trp Lys Phe Arg Gly Thr Gly Ala Gly Leu Phe Asp Ala Asp Phe 
        435                 440                 445             


Val Pro Glu Glu Glu Arg Ala Gly Glu Ser Gly Arg Lys Ala Gly Ser 
    450                 455                 460                 


Tyr Thr Asp Leu Gly Cys Leu Phe Ala Glu Asp Asp Gly Ile Arg Asn 
465                 470                 475                 480 


Gln Arg Arg Ile Ala Asp Arg Ile Asn Tyr Val Asn Tyr Gly Asn Tyr 
                485                 490                 495     


Leu Arg Met Arg Lys Ala Ala Glu Asp Glu Phe Thr Leu Phe Trp Cys 
            500                 505                 510         


Ala Tyr Ile Lys Asp Tyr Ile Glu Glu Asn Tyr Val Thr Lys Ile Arg 
        515                 520                 525             


Glu Ala Lys Arg Thr Gly Gly Lys Arg Arg Leu Lys Glu Thr Asp Cys 
    530                 535                 540                 


Glu Ala Glu Arg Met Met Glu Lys Cys Trp His Asp Ile Ile Arg Tyr 
545                 550                 555                 560 


Ile Cys Gly Lys Tyr Ile His Ile Gly Lys Ala Val Tyr His Phe Ala 
                565                 570                 575     


Ile Pro Glu Asp Leu Leu Ala Asn Pro Gly Glu Val Arg Ser Phe Gly 
            580                 585                 590         


Asp Val His Ala Lys Tyr Ala Asp Gly Ile Thr Ser Phe Asp Tyr Glu 
        595                 600                 605             


Asp Ile Lys Ala Glu Glu Asn Leu Gln Lys Ser Ile Phe Asn Val Leu 
    610                 615                 620                 


Val Ser Ala Val Ala Asn Tyr Ser Arg Ser Val Val Asp Leu Ser Ser 
625                 630                 635                 640 


Glu Arg Ala Glu Glu Leu Arg Arg Leu Pro Gly Asn Glu Arg Leu Asn 
                645                 650                 655     


Glu Asp Val Leu Met Met Lys Glu Thr His Leu Lys Glu Leu Leu Leu 
            660                 665                 670         


Pro Asp Ala Lys Lys Arg Leu Leu Arg Tyr Phe Gly Gly Tyr Ser Ala 
        675                 680                 685             


Cys Glu Gly Leu Ser Gly Val Thr Ser Glu Glu Leu Ala Trp Glu Met 
    690                 695                 700                 


Arg Thr Val Leu Ser Thr Leu Arg Asn Glu Ser Phe His Tyr Thr Phe 
705                 710                 715                 720 


Gly Lys Lys Lys Lys Leu Asp Tyr Lys Val Ala Lys Gln Leu Trp Met 
                725                 730                 735     


Gln Ala Ile Arg Ala Asn Arg Gln Leu Ile Leu Asp Lys Tyr Tyr Ser 
            740                 745                 750         


Asn Asn Thr Cys Arg Tyr Tyr Ser Pro Asn Ser Ile Lys Ala Leu Ile 
        755                 760                 765             


Glu Gln Gly Tyr Arg Ser Tyr Glu Glu Arg Glu Ala Gln Ile Pro Ala 
    770                 775                 780                 


Phe Lys Thr Val Trp Lys Lys Ala Glu Leu Ala Lys Tyr Leu Ala Asp 
785                 790                 795                 800 


Lys Lys Val Met Pro Ala Glu Ile Ser Gly Glu Glu Lys Glu Arg Val 
                805                 810                 815     


Ile Phe Gln Gly Ala Phe Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg 
            820                 825                 830         


Glu Phe Thr Val Gly Asn Thr Ala Ala Lys Tyr Phe Phe Asp Ala Val 
        835                 840                 845             


Glu Arg Tyr Cys Lys Glu Asn Glu Thr Gly Pro Tyr Lys Asn Pro Ala 
    850                 855                 860                 


Lys Ser Phe Asn Asp Tyr Val Asn Gly Ala Phe Asn Asn Lys Gly Val 
865                 870                 875                 880 


Lys Val Gln Lys Gly Leu Ser Asp Leu Tyr Arg Glu Gly Lys Ile Thr 
                885                 890                 895     


Phe Gly Val Val Cys Gln Thr Ile Met Ala Glu Tyr Thr Gln Gln Asn 
            900                 905                 910         


Glu Lys Ser Glu Gly Glu Ala Ile Tyr Gln His Phe Lys Met Leu Phe 
        915                 920                 925             


Pro Leu Cys Met Arg Lys Gly Phe Gln Lys Tyr Val Glu Glu Lys His 
    930                 935                 940                 


Lys Glu Leu Leu Gln Pro Val Ile Arg Glu Met Gly Ser Arg Glu Asp 
945                 950                 955                 960 


Phe Leu Thr Asn Ile His Ile Gly Cys Phe Asp Asp Phe Cys Arg Glu 
                965                 970                 975     


Asp Gly Met Tyr Glu Tyr Asp Trp Phe Val Val Ala His Leu Ile His 
            980                 985                 990         


Pro Lys Arg Leu Asn Glu Leu Val  Gly Asn Leu Lys Asp  Tyr Met Gln 
        995                 1000                 1005             


Phe Lys  Gln Asp Ile Leu Arg  Arg Ala Asp Tyr Val  Glu Gln Phe 
    1010                 1015                 1020             


Thr Lys  Glu Glu Leu Ala Ala  Met Lys Ala Arg Thr  Glu Glu Lys 
    1025                 1030                 1035             


Leu Gln  Lys Ile Ser Gly Ile  Leu Arg Val Ala Glu  Phe Val Arg 
    1040                 1045                 1050             


Gly Ile  Ala Gly Arg Val Ser  Asn Thr Phe Ser Asp  Tyr Tyr Glu 
    1055                 1060                 1065             


Ser Glu  Glu Ala Tyr Ala Ser  Tyr Leu Glu Gln Tyr  Ile Glu Phe 
    1070                 1075                 1080             


Pro Arg  Ile Lys Gly Ser Thr  Val Phe Glu Ser Phe  Arg Asp Phe 
    1085                 1090                 1095             


Cys Val  Asn Thr Leu Pro Gly  Gly Ala Val Met Asp  Val Tyr Met 
    1100                 1105                 1110             


Asp Glu  Lys Asn Pro Arg Ile  Leu Arg Asn Val Glu  Val Ala Arg 
    1115                 1120                 1125             


Met Tyr  Ala Gly Gly Asp Ile  Gly Leu Arg Thr Arg  Lys Lys Val 
    1130                 1135                 1140             


Thr Ala  Glu Glu Leu Lys Arg  Tyr Tyr Gln Asn Glu  Ala Glu Val 
    1145                 1150                 1155             


Ala Ala  Leu Leu Lys Ala Gly  Leu Cys Ala Thr Ala  Glu Asp Gln 
    1160                 1165                 1170             


Lys Arg  Val Lys Ala Gln Gln  Glu Leu Arg Asn Arg  Ile Thr Leu 
    1175                 1180                 1185             


Thr Asp  Val Thr Glu Ile Gln  Glu Val Ile Asn Asp  Leu Leu Ser 
    1190                 1195                 1200             


Gln Leu  Val Thr Phe Ser Tyr  Phe Arg Glu Arg Asp  Glu Met Tyr 
    1205                 1210                 1215             


Leu Leu  Leu Gly Phe Tyr Tyr  Met Ala Leu Gln Ser  Asp Gly Asp 
    1220                 1225                 1230             


Trp Gly  Glu Glu Leu Arg Val  Phe Asp Gly Lys Lys  Leu Gln Val 
    1235                 1240                 1245             


Glu Asn  Gly Phe Val Leu Tyr  Gln Leu Leu Ser Ala  Phe Thr Tyr 
    1250                 1255                 1260             


Gly Leu  Asn Met Tyr Ser Glu  Ala Ala Pro Asp Gly  Lys Gly Gly 
    1265                 1270                 1275             


Ser Gln  Ala Gly Lys Ile Gly  Glu Phe Ile Lys Ala  His Pro Asn 
    1280                 1285                 1290             


Ser Trp  Asp Arg Ala Leu Arg  Leu Phe Val Asp Asp  Gly Ala Cys 
    1295                 1300                 1305             


Glu Glu  Val Ser Arg Lys Ala  Arg Asn Tyr Val Asp  His Phe Arg 
    1310                 1315                 1320             


Tyr Tyr  Val Lys Pro Asp Arg  Ser Ile Met Asp Leu  Tyr Ala Val 
    1325                 1330                 1335             


Tyr His  Glu Tyr Phe Phe Asp  Tyr Ser Thr Lys Met  Arg Lys Ser 
    1340                 1345                 1350             


Val Leu  Gln Asn Phe Ala Ser  Ile Leu Glu Arg Tyr  Phe Val Leu 
    1355                 1360                 1365             


Thr Lys  Phe Lys Leu Gly Gly  Glu Arg Gly Ala Gln  Thr Leu Glu 
    1370                 1375                 1380             


Ala Glu  Leu Ser Gly Asp Lys  Phe Thr Tyr Lys Leu  Ser Asp Thr 
    1385                 1390                 1395             


Lys Ala  Lys Pro Val Val Leu  Pro Ala Arg Asn Lys  Glu Phe Leu 
    1400                 1405                 1410             


Glu Asn  Leu Lys Asn Glu Leu  Asn Tyr Arg Gln Glu  
    1415                 1420                 1425 


<210>  387
<211>  1425
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  387

Met Lys Leu Ser Lys Val Asp Arg Ile Arg Val Ala Val Gly Lys Thr 
1               5                   10                  15      


Gly Lys Thr Glu Asn Gly Asn Ser Gln Gly Arg Gly Val Leu Tyr Arg 
            20                  25                  30          


Ser Pro Lys Gly Asn Lys Thr Val Ala Val Asp Ala Val Val Glu Glu 
        35                  40                  45              


Arg Ile Arg Asn Ala Asn Arg Leu Tyr Ser Ala Phe Phe Arg Cys Ala 
    50                  55                  60                  


Tyr Pro Glu Glu Pro Glu Arg His Phe Glu Glu Ile Ile Lys Arg Met 
65                  70                  75                  80  


Ala Thr Gly Lys Lys Ser Gly Ala Gln Ile Leu Lys Glu Tyr Ile Gly 
                85                  90                  95      


Tyr Glu Gly Gln Lys Asn Arg Lys Pro Tyr Thr Phe Tyr Val Asn Lys 
            100                 105                 110         


Cys Ala Tyr Arg Pro Ala Gly Lys Glu Leu Gly Gln Val Leu Arg Leu 
        115                 120                 125             


Phe Val Lys Glu Arg Leu Gly Gln Asn Trp Gln Asn Pro Glu Ala Ala 
    130                 135                 140                 


Glu Ala Ala Val Ala Leu Leu Thr Cys Leu Cys Glu Gly Lys Thr Asn 
145                 150                 155                 160 


Arg Tyr Thr Glu Asn Thr Ala Asp Gly Pro Val Leu Thr Glu Leu Ser 
                165                 170                 175     


Glu Gln Thr Val Thr Gln Leu Glu Gln Val Ser Arg Leu Gly Gly Ser 
            180                 185                 190         


Ile Leu Val Pro Lys Thr Glu Arg Leu Glu Thr Ile Val Thr Val Ile 
        195                 200                 205             


Leu Arg Leu Thr Ala Glu Gln Cys Asn Thr Ser Leu Tyr Val Asn Gly 
    210                 215                 220                 


Gly Thr Lys Glu Ala Gln Asp Ala Asp Leu Glu Lys Gln Ile Ala Leu 
225                 230                 235                 240 


Leu Lys Ser Leu Gln Thr Lys Pro Leu Leu Leu Lys Glu Arg Phe Asp 
                245                 250                 255     


Lys Val Thr Lys Gln Thr Ile Arg Asp Glu Gln Lys Leu Ser Glu Phe 
            260                 265                 270         


Ser Tyr Lys Asp Ala Thr Lys Glu Arg Met Glu Ala Val Val Val Arg 
        275                 280                 285             


Met Arg Lys Thr Leu Lys Lys Gly Ala Ser Arg Glu Val Ala Val Glu 
    290                 295                 300                 


Leu Leu Gln Ala Leu Ala Gln Tyr Asp Gly Lys Thr Trp Asp Gly Trp 
305                 310                 315                 320 


Leu Thr Gln Met Leu Glu Thr Glu Ala Ser Lys Lys Lys Leu Lys Asp 
                325                 330                 335     


Phe Ile Leu Ala Val Asn Lys Asp Phe His His Phe His Val Ile Lys 
            340                 345                 350         


Ser Val Lys Asn Thr Ala Val Ala Val Ser His Ser Glu Asp Asn Thr 
        355                 360                 365             


Leu Gln Leu Ser Gly Ala Lys Lys Lys Thr Lys Gly Ala Met Gln Asp 
    370                 375                 380                 


Ala Leu Phe Ala Tyr Ala Gln Ser Glu Glu Ser Ser Asp Glu Thr Leu 
385                 390                 395                 400 


His Arg Ile Lys Arg Ile Leu Phe Thr Tyr Val Leu Gly Gly Arg Gln 
                405                 410                 415     


Asp Asn Thr Leu Arg Leu Thr Glu Lys Thr His Leu Ala Lys Glu Leu 
            420                 425                 430         


Leu Trp Lys Phe Arg Gly Thr Gly Ala Gly Leu Phe Asp Ala Asp Phe 
        435                 440                 445             


Val Pro Glu Glu Glu Arg Ala Gly Glu Ser Gly Arg Lys Ala Gly Ser 
    450                 455                 460                 


Tyr Thr Asp Leu Gly Cys Leu Phe Ala Glu Asp Asp Gly Ile Arg Asn 
465                 470                 475                 480 


Gln Arg Arg Ile Ala Asp Arg Ile Asn Tyr Val Asn Tyr Gly Asn Tyr 
                485                 490                 495     


Leu Arg Met Arg Lys Ala Ala Glu Asp Glu Phe Thr Leu Phe Trp Cys 
            500                 505                 510         


Ala Tyr Ile Lys Asp Tyr Ile Glu Glu Asn Tyr Val Thr Lys Ile Arg 
        515                 520                 525             


Glu Ala Lys Arg Thr Gly Gly Lys Arg Arg Leu Lys Glu Thr Asp Cys 
    530                 535                 540                 


Glu Ala Glu Arg Met Met Glu Lys Cys Trp His Asp Ile Ile Arg Tyr 
545                 550                 555                 560 


Ile Cys Gly Lys Tyr Ile His Ile Gly Lys Ala Val Tyr His Phe Ala 
                565                 570                 575     


Ile Pro Glu Asp Leu Leu Ala Asn Pro Gly Glu Val Arg Ser Phe Gly 
            580                 585                 590         


Asp Val His Ala Lys Tyr Ala Asp Gly Ile Thr Ser Phe Asp Tyr Glu 
        595                 600                 605             


Asp Ile Lys Ala Glu Glu Asn Leu Gln Lys Ser Ile Phe Asn Val Leu 
    610                 615                 620                 


Val Ser Ala Val Ala Asn Tyr Ser Arg Ser Val Val Asp Leu Ser Ser 
625                 630                 635                 640 


Glu Arg Ala Glu Glu Leu Arg Arg Leu Pro Gly Asn Glu Arg Leu Asn 
                645                 650                 655     


Glu Asp Val Leu Met Met Lys Glu Thr His Leu Lys Glu Leu Leu Leu 
            660                 665                 670         


Pro Asp Ala Lys Lys Arg Leu Leu Arg Tyr Phe Gly Gly Tyr Ser Ala 
        675                 680                 685             


Cys Glu Gly Leu Ser Gly Val Thr Ser Glu Glu Leu Ala Trp Glu Met 
    690                 695                 700                 


Arg Thr Val Leu Ser Thr Leu Arg Asn Glu Ser Phe His Tyr Thr Phe 
705                 710                 715                 720 


Gly Lys Lys Lys Lys Leu Asp Tyr Lys Val Ala Lys Gln Leu Trp Met 
                725                 730                 735     


Gln Ala Ile Arg Ala Asn Arg Gln Leu Ile Leu Asp Lys Tyr Tyr Ser 
            740                 745                 750         


Asn Asn Thr Cys Arg Tyr Tyr Ser Pro Asn Ser Ile Lys Ala Leu Ile 
        755                 760                 765             


Glu Gln Gly Tyr Arg Ser Tyr Glu Glu Arg Glu Ala Gln Ile Pro Ala 
    770                 775                 780                 


Phe Lys Thr Val Trp Lys Lys Ala Glu Leu Ala Lys Tyr Leu Ala Asp 
785                 790                 795                 800 


Lys Lys Val Met Pro Ala Glu Ile Ser Gly Glu Glu Lys Glu Arg Val 
                805                 810                 815     


Ile Phe Gln Gly Ala Phe Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg 
            820                 825                 830         


Glu Phe Thr Val Gly Asn Thr Ala Ala Lys Tyr Phe Phe Asp Ala Val 
        835                 840                 845             


Glu Arg Tyr Cys Lys Glu Asn Glu Thr Gly Pro Tyr Lys Asn Pro Ala 
    850                 855                 860                 


Lys Ser Phe Asn Asp Tyr Val Asn Gly Ala Phe Asn Asn Lys Gly Val 
865                 870                 875                 880 


Lys Val Gln Lys Gly Leu Ser Asp Leu Tyr Arg Glu Gly Lys Ile Thr 
                885                 890                 895     


Phe Gly Val Val Cys Gln Thr Ile Met Ala Glu Tyr Thr Gln Gln Asn 
            900                 905                 910         


Glu Lys Ser Glu Gly Glu Ala Ile Tyr Gln His Phe Lys Met Leu Phe 
        915                 920                 925             


Pro Leu Cys Met Arg Lys Gly Phe Gln Lys Tyr Val Glu Glu Lys His 
    930                 935                 940                 


Lys Glu Leu Leu Gln Pro Val Ile Arg Glu Met Gly Ser Arg Glu Asp 
945                 950                 955                 960 


Phe Leu Thr Asn Ile His Ile Gly Cys Phe Asp Asp Phe Cys Arg Glu 
                965                 970                 975     


Asp Gly Met Tyr Glu Tyr Asp Trp Phe Val Val Ala His Leu Ile His 
            980                 985                 990         


Pro Lys Arg Leu Asn Glu Leu Val  Gly Asn Leu Lys Asp  Tyr Met Gln 
        995                 1000                 1005             


Phe Lys  Gln Asp Ile Leu Arg  Arg Ala Asp Tyr Val  Glu Gln Phe 
    1010                 1015                 1020             


Thr Lys  Glu Glu Leu Ala Ala  Met Lys Ala Arg Thr  Glu Glu Lys 
    1025                 1030                 1035             


Leu Gln  Lys Ile Ser Gly Ile  Leu Arg Val Ala Glu  Phe Val Arg 
    1040                 1045                 1050             


Gly Ile  Ala Gly Arg Val Ser  Asn Thr Phe Ser Asp  Tyr Tyr Glu 
    1055                 1060                 1065             


Ser Glu  Glu Ala Tyr Ala Ser  Tyr Leu Glu Gln Tyr  Ile Glu Phe 
    1070                 1075                 1080             


Pro Arg  Ile Lys Gly Ser Thr  Val Phe Glu Ser Phe  Arg Asp Phe 
    1085                 1090                 1095             


Cys Val  Asn Thr Leu Pro Gly  Gly Ala Val Met Asp  Val Tyr Met 
    1100                 1105                 1110             


Asp Glu  Lys Asn Pro Arg Ile  Leu Arg Asn Val Glu  Val Ala Arg 
    1115                 1120                 1125             


Met Tyr  Ala Gly Gly Asp Ile  Gly Leu Arg Thr Arg  Lys Lys Val 
    1130                 1135                 1140             


Thr Ala  Glu Glu Leu Lys Arg  Tyr Tyr Gln Asn Glu  Ala Glu Val 
    1145                 1150                 1155             


Ala Ala  Leu Leu Lys Ala Gly  Leu Cys Ala Thr Ala  Glu Asp Gln 
    1160                 1165                 1170             


Lys Arg  Val Lys Ala Gln Gln  Glu Leu Arg Asn Arg  Ile Thr Leu 
    1175                 1180                 1185             


Thr Asp  Val Thr Glu Ile Gln  Glu Val Ile Asn Asp  Leu Leu Ser 
    1190                 1195                 1200             


Gln Leu  Val Thr Phe Ser Tyr  Phe Arg Glu Arg Asp  Glu Met Tyr 
    1205                 1210                 1215             


Leu Leu  Leu Gly Phe Tyr Tyr  Met Ala Leu Gln Ser  Asp Gly Asp 
    1220                 1225                 1230             


Trp Gly  Glu Glu Leu Arg Val  Phe Asp Gly Lys Lys  Leu Gln Val 
    1235                 1240                 1245             


Glu Asn  Gly Phe Val Leu Tyr  Gln Leu Leu Ser Ala  Phe Thr Tyr 
    1250                 1255                 1260             


Gly Leu  Asn Met Tyr Ser Glu  Ala Ala Pro Asp Gly  Lys Gly Gly 
    1265                 1270                 1275             


Ser Gln  Ala Gly Lys Ile Gly  Glu Phe Ile Lys Ala  His Pro Asn 
    1280                 1285                 1290             


Ser Trp  Asp Arg Ala Leu Arg  Leu Phe Val Asp Asp  Gly Ala Cys 
    1295                 1300                 1305             


Glu Glu  Val Ser Arg Lys Ala  Arg Asn Tyr Val Asp  His Phe Arg 
    1310                 1315                 1320             


Tyr Tyr  Val Lys Pro Asp Arg  Ser Ile Met Asp Leu  Tyr Ala Val 
    1325                 1330                 1335             


Tyr His  Glu Tyr Phe Phe Asp  Tyr Ser Thr Lys Met  Arg Lys Ser 
    1340                 1345                 1350             


Val Leu  Gln Asn Phe Ala Ser  Ile Leu Glu Arg Tyr  Phe Val Leu 
    1355                 1360                 1365             


Thr Lys  Phe Lys Leu Gly Gly  Glu Arg Gly Ala Gln  Thr Leu Glu 
    1370                 1375                 1380             


Ala Glu  Leu Ser Gly Asp Lys  Phe Thr Tyr Lys Leu  Ser Asp Thr 
    1385                 1390                 1395             


Lys Ala  Lys Pro Val Val Leu  Pro Ala Arg Asn Lys  Glu Phe Leu 
    1400                 1405                 1410             


Glu Asn  Leu Lys Asn Glu Leu  Asn Tyr Arg Gln Glu  
    1415                 1420                 1425 


<210>  388
<211>  1214
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  388

Met Lys Asn Val Phe Ser Phe Val Pro Asp Lys Ile Val Lys Lys Arg 
1               5                   10                  15      


Met Cys Thr Met Lys Leu Thr Lys Ser Lys Asn Ala Gln Glu Ala Phe 
            20                  25                  30          


Phe Tyr Arg Asn Thr His Met Gly Lys Leu Tyr Met Arg Ser Ala Phe 
        35                  40                  45              


Ser Glu Asp Lys Thr Asp Ser Thr Ile Asp Asn Leu Pro Phe Lys Glu 
    50                  55                  60                  


Ser Leu Ala Arg Arg Ile Leu Leu Arg Cys Asp Lys Thr Lys Ser His 
65                  70                  75                  80  


Lys Gln Asn Pro Phe Lys Ser Phe Met Glu Glu Leu Ile Asp Lys Glu 
                85                  90                  95      


Lys Ala Val Leu Pro Ser Lys Glu Val Ile Gly Tyr Asp Lys Thr Phe 
            100                 105                 110         


Gln Ala Val Arg Tyr Phe Ser Pro Tyr Gly Arg Ala Leu Arg Ile Gly 
        115                 120                 125             


Gln Gly Gly Asn Gly Ile Thr Phe Glu Lys Leu Leu Ile Glu His Tyr 
    130                 135                 140                 


Asp Asn Asn Lys Asp Ile Ser Glu Glu Leu Lys Lys Ile Ser Ala Met 
145                 150                 155                 160 


Leu Lys Leu Arg Arg Thr Tyr Lys Lys Asp His Leu Lys Lys Ser Ile 
                165                 170                 175     


Lys Asn Asn Lys Ile Val Phe Pro Leu Val Ile Asn Glu Ala Asn Thr 
            180                 185                 190         


Ser Lys Ile Gly Lys Gly Glu Trp Leu Leu Asp Phe Ile Asn Asn Glu 
        195                 200                 205             


Lys Lys Phe Thr Asp Tyr Lys Asn Trp Tyr Asp Tyr Ala Lys Leu Tyr 
    210                 215                 220                 


Glu Thr Lys Leu Lys Pro Leu Gln Thr Asn Leu Gly Tyr Leu Lys Asn 
225                 230                 235                 240 


Pro Gln Val Trp Gly Gly Leu Leu Tyr Ala Glu Val Lys Lys Tyr His 
                245                 250                 255     


His Glu Leu Tyr Lys Thr Lys Lys Ser Glu Leu Asn Cys Glu Lys Lys 
            260                 265                 270         


Leu Gln Glu Phe Gly Phe Tyr Leu Asn Glu Val Gln Asp Tyr Phe Arg 
        275                 280                 285             


His Tyr Phe Gly Ser Ser Lys Ala Gly Lys Ser Leu Asn Lys Ala Ala 
    290                 295                 300                 


Lys Ile Asp Arg Leu Ile Glu Ile Lys Glu Gly Ala Val Glu Glu Ser 
305                 310                 315                 320 


Tyr Met Tyr Lys Trp Ile Lys Ala His Ile Thr Asn Lys Ile Thr Ala 
                325                 330                 335     


Leu Leu Ile Gln Asn Gly Lys Phe Met His Tyr Lys Val Glu His Pro 
            340                 345                 350         


Thr Ser Asp Ile Leu Ser Asn Ile Gln Ile Glu Glu Ser Phe Lys Lys 
        355                 360                 365             


Gln Leu Phe Leu Ser Ile Ala Trp Ala Thr Thr Arg Leu Asn Tyr Phe 
    370                 375                 380                 


Phe Asp Tyr Gly Ser Asn Asn Asp Val Leu Leu Gly Glu Pro Lys Asn 
385                 390                 395                 400 


Asn Ser Thr Val Gly Thr Asn Ile Gln Gly Asp Ile Leu Ser Glu Phe 
                405                 410                 415     


Asp Glu Asp Thr Thr Leu Lys Asn Ile Tyr Gln Lys Asn Ile Lys Asn 
            420                 425                 430         


Thr Lys Ala Tyr Met Glu Tyr Phe Leu Ala Glu Leu Lys Lys Ser Glu 
        435                 440                 445             


Asn Asn Asn Lys Asn Val Phe Gln Glu Lys Val Cys Thr Thr Phe Pro 
    450                 455                 460                 


Ile His Ile Gln Glu Asn Asn Ser Asp Asp Thr Ile Glu Ala Leu Leu 
465                 470                 475                 480 


Asp Ile Leu Asp Ala Ala Lys Glu Ser Ile Ser Tyr Leu Arg Asn Asn 
                485                 490                 495     


Val Phe His Pro Gln Lys Glu Tyr Leu Tyr Glu Leu Thr Leu Pro Glu 
            500                 505                 510         


Lys Ile Lys Gly Ile Val Glu Lys Asp Tyr Phe Ala Lys Thr Lys Glu 
        515                 520                 525             


Val Met Lys Thr Asp Ile Ser Gln Ile Asn Ser Cys Phe Lys Glu Lys 
    530                 535                 540                 


Ile Arg Ser Ala Leu Ile Ala Asp Val Tyr Pro Leu Glu Ile Leu Gln 
545                 550                 555                 560 


Asn Leu Phe Thr Asn Cys Lys Leu Ser Phe Tyr Leu Tyr Ala Pro Lys 
                565                 570                 575     


Tyr Glu Leu Met Pro Ala Phe Arg Lys Val Tyr Gln Arg Gly Ala Asn 
            580                 585                 590         


Leu Cys Ser Gln Gly Gly Thr Gln Arg Asn Leu Ser Trp Phe Tyr Asn 
        595                 600                 605             


Lys Pro Val Val Ser Arg Gly Ala Asp Gly Leu Arg Asp Ile Asn Asp 
    610                 615                 620                 


Ile Lys Gln Trp Gln Ala Tyr Lys Asn Leu Leu Gln Met Ile Tyr Glu 
625                 630                 635                 640 


His Ser Phe Leu Pro Ala Val His Glu Asp Glu Ser Leu Ile Thr Lys 
                645                 650                 655     


Tyr Ile Tyr Glu Thr Ile Gln Gln Ser Gln Glu Ala Ser Arg Asp Arg 
            660                 665                 670         


Asn Lys Glu Tyr Cys Phe Arg Tyr Arg Asn Met Pro Lys Tyr Lys Ser 
        675                 680                 685             


Ser Ser Leu Ala Ala Tyr Met Ser Asn Leu Gln Arg Leu Gln Ser Ala 
    690                 695                 700                 


Glu Glu Ser Asn Gln His Asp Asp Thr Lys Ser Lys Thr Asp Asn Lys 
705                 710                 715                 720 


Asn Tyr Tyr Ile Asp Phe Val Gln Asp Phe Phe Val Arg Ala Phe Asp 
                725                 730                 735     


Arg Tyr Leu Glu Gly His Leu Ser Ser Ile Lys Arg Tyr Leu Leu Pro 
            740                 745                 750         


Asp Ala Gly Asn Lys Leu His Val Thr Glu Lys Glu Asp Val Glu Thr 
        755                 760                 765             


Thr Leu Ser Gln Leu Phe Gln Lys Glu Asn Pro Thr Ile Cys Met Lys 
    770                 775                 780                 


Asp Ala Asn Val Ile Asn Glu Asn Asp Glu Phe Cys Leu Leu Phe Tyr 
785                 790                 795                 800 


Pro Phe Leu Arg Met Leu Glu Arg Arg Glu Leu Ser Asn Leu Gln His 
                805                 810                 815     


Gln Val Ile Arg Tyr Arg Cys Ser Phe Lys His Arg Leu Ser Ile Glu 
            820                 825                 830         


Val Asp Ser Ser Glu Lys Leu Glu Arg Leu Ile Ala Met Leu Ile Phe 
        835                 840                 845             


Thr Phe Pro Asp His Ile Asp Glu Glu Asp Cys Tyr Lys Asp Met Val 
    850                 855                 860                 


Lys Lys Tyr Phe Gly Lys Phe Val Glu Gly Ser Leu Lys Asp Tyr Leu 
865                 870                 875                 880 


Asp Leu Tyr Phe Gln Ser Gly Glu Lys Leu Ile Gln Gln Lys Ser Met 
                885                 890                 895     


Leu Ala Leu Met Arg Thr Gly Ser Met Ala Leu Tyr Ser Glu Met Phe 
            900                 905                 910         


Ser Pro Ile Tyr Lys Ile Thr Ser Glu Asp Tyr Asn Lys Tyr Lys Ser 
        915                 920                 925             


Tyr Cys Gln Leu Gly Glu Asn Pro Gly Gly Lys Gln Leu Ser Pro Ile 
    930                 935                 940                 


Glu Gln Ala Gln Gln Gln Leu Ala Ser Leu His Gln Glu Leu Cys Glu 
945                 950                 955                 960 


Glu Lys Ser Ile Ser Lys Asp Asn Glu Lys Leu Arg Lys Tyr Lys Glu 
                965                 970                 975     


Cys Leu Val Leu Val His Glu Tyr Ser Glu Leu Arg Arg Lys Leu Thr 
            980                 985                 990         


Phe Asp Leu Leu Tyr Glu Ile His  Leu Ile His Val Asp  Ile Leu Gly 
        995                 1000                 1005             


Arg Phe  Ala Ser Phe Ala Ala  Asp Trp Glu Arg Asp  Met His Phe 
    1010                 1015                 1020             


Leu Leu  Leu Gly Leu Tyr Gly  Leu Gly Gln Gln Asn  Gln Ile Asp 
    1025                 1030                 1035             


Lys Leu  Leu Ser Phe Lys Ser  Gln Glu Glu Val Asp  Asn Ile Phe 
    1040                 1045                 1050             


Arg Tyr  Met Arg Arg Glu Lys  Ser Met Thr Ala Lys  Phe Lys Asn 
    1055                 1060                 1065             


Ala Leu  Lys Asn Glu Ile Asn  Arg Lys Thr Leu Glu  Glu Leu Cys 
    1070                 1075                 1080             


Leu Tyr  Asn Cys Gln Asp Gly  Leu Asp Lys Val Ile  Asn Val Arg 
    1085                 1090                 1095             


Asn Thr  Leu Ala His Leu Asn  His Met Thr Gln Ile  Ser Tyr Lys 
    1100                 1105                 1110             


Asn Glu  Tyr Gln Lys Ser Ile  Phe Glu Leu Leu Thr  Ala Ile Ser 
    1115                 1120                 1125             


Lys Leu  Leu Asn Tyr Asp Leu  Lys Arg Lys Asn Ser  Val Thr Arg 
    1130                 1135                 1140             


Val Leu  Lys Ala Leu Leu Asn  Lys Tyr His Ile Lys  Leu Ser Leu 
    1145                 1150                 1155             


Tyr Gln  Lys Asn Asp Asp Tyr  Glu Cys Ile Ser Ile  Lys Ser Glu 
    1160                 1165                 1170             


Glu Ile  Val His Leu Lys Asn  Leu Arg Ile Arg Glu  Asn Lys Lys 
    1175                 1180                 1185             


Arg Ile  Glu Leu Pro Ala Gln  Asp Val Leu Phe Val  Glu Cys Val 
    1190                 1195                 1200             


Ala Lys  Leu Leu Asp Phe Ser  Tyr Asn Lys Lys 
    1205                 1210                 


<210>  389
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  389

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  390
<211>  1101
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  390

Met Arg Ile Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Ile Tyr Ser Glu 
            20                  25                  30          


Gln Ala Val Ser Asn Glu Thr Asn Asn Ile Leu Pro Val Lys Lys Met 
        35                  40                  45              


Asp Ser Phe Asn Leu Ser Ile Leu Asn Lys Thr Ile Ile Lys Phe Glu 
    50                  55                  60                  


Thr Val Lys Lys Gln Lys Leu Asn Leu Asp Gln Tyr Lys Ile Val Glu 
65                  70                  75                  80  


Lys Ile Phe Lys Tyr Pro Lys Gln Glu Leu Pro Lys Gln Ile Asn Ala 
                85                  90                  95      


Glu Glu Ile Leu Gln Phe Leu Asn His Lys Phe Gln Glu Pro Val Lys 
            100                 105                 110         


Tyr Trp Lys Asn Gly Lys Glu Glu Ser Phe Asn Leu Thr Leu Leu Ile 
        115                 120                 125             


Val Glu Ala Val Lys Thr Gln Glu Lys Arg Lys Leu Gln Pro Tyr Tyr 
    130                 135                 140                 


Asp Trp Lys Thr Trp Tyr Ile Gln Thr Lys Ser Asp Leu Leu Lys Lys 
145                 150                 155                 160 


Ser Ile Glu Asn Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg 
                165                 170                 175     


Lys Lys Ala Leu Leu Ala Trp Glu Thr Glu Phe Thr Thr Ser Gly Ser 
            180                 185                 190         


Ile Asp Leu Thr His Phe His Lys Val Tyr Met Thr Asp Val Leu Cys 
        195                 200                 205             


Thr Ala Leu Gln Lys Val Glu Pro Ser Ala Asp Glu Arg Gly Lys Met 
    210                 215                 220                 


Asn Ser Asn Ala Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Asn His 
225                 230                 235                 240 


Gln Pro Ala Ile Phe Gly Thr Arg Glu Ala Pro Asn Glu Val Asn Arg 
                245                 250                 255     


Ala Asp Asn Gln Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu 
            260                 265                 270         


Glu His Tyr Phe Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Ala Asp 
        275                 280                 285             


Asp Ile Ser His Tyr Leu Lys Ala Gln Thr Leu Lys Thr Thr Ile Glu 
    290                 295                 300                 


Lys Gln Leu Val Asn Ala Ile Arg Ala Asn Ile Ile Gln Gln Gly Lys 
305                 310                 315                 320 


Thr Asn His His Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile 
                325                 330                 335     


Arg Ile Lys Thr Asn Glu Ala Phe Val Leu Asn Leu Ile Gly Thr Cys 
            340                 345                 350         


Ala Phe Ala Ala Asn Asn Ile Arg Asn Met Val Asp Lys Glu Gln Ile 
        355                 360                 365             


Ser Asp Ile Leu Gly Lys Arg Glu Phe Ile Asp Ser Leu Thr Lys Ser 
    370                 375                 380                 


Arg Ile Ser Ser Gln Leu Tyr Ser Phe Phe Phe Gly Glu Asn Leu Ser 
385                 390                 395                 400 


Thr Asn Lys Ala Glu Lys Glu Thr Gln Leu Trp Gly Ile Arg Gly Ala 
                405                 410                 415     


Val Gln Gln Ile Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu 
            420                 425                 430         


Thr Thr Ile Phe Asn Ile Cys Lys Phe Glu Asn Pro Thr Asp Ala Asp 
        435                 440                 445             


Pro Lys Gln Gln Thr Asn Tyr Val Asp Ser Ile Tyr Lys Thr Leu Phe 
    450                 455                 460                 


Ile Lys Glu Leu Glu Lys Ile Pro Glu Ala Phe Ala Gln Gln Leu Lys 
465                 470                 475                 480 


Thr Gly Gly Ala Leu Ser Tyr Tyr Thr Val Glu Asn Leu Lys Thr Leu 
                485                 490                 495     


Leu Thr Thr Phe Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala 
            500                 505                 510         


Pro Gly Phe Lys Lys Val Leu Asn Gly Gly Ile Asn Tyr Gln Asn Ala 
        515                 520                 525             


Lys Gln Asp Glu Ser Phe Tyr Glu Leu Met Leu Glu Arg Tyr Leu Arg 
    530                 535                 540                 


Lys Glu Asn Phe Ala Glu Glu Ala Tyr Asn Ala Arg Tyr Phe Leu Leu 
545                 550                 555                 560 


Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Lys Phe Thr Ala Asp Arg 
                565                 570                 575     


Lys Ala Phe Ala Asp Ser Val Gly Phe Val Gln Leu Gln Asn Arg Lys 
            580                 585                 590         


Gln Ala Glu Asn Ser Lys Arg Pro Lys Ala Phe Ala Phe Glu Ala Val 
        595                 600                 605             


Arg Pro Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala Tyr Val 
    610                 615                 620                 


Gln Ser Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys Ala Thr 
625                 630                 635                 640 


Asp Glu Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val Phe Ile 
                645                 650                 655     


Lys Gly Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe Val Gln 
            660                 665                 670         


Val Pro Gln Pro Gln Leu Thr Thr Thr Asp Ser Asn Gln Gln Lys Ala 
        675                 680                 685             


Asp Lys Leu Asn Gln Leu Glu Ala Ser Ile Thr Ala Asp Cys Lys Leu 
    690                 695                 700                 


Thr Ala Gln Tyr Ala Lys Thr Asp Asp Ala Thr His Ile Ala Phe Tyr 
705                 710                 715                 720 


Val Phe Cys Lys Leu Leu Asp Ala Gly His Leu Ser Asn Leu Arg Asn 
                725                 730                 735     


Glu Leu Ile Lys Phe Arg Gly Ser Val Lys Asp Phe Asp Phe His His 
            740                 745                 750         


Leu Leu Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val Val Pro 
        755                 760                 765             


Thr Asp Tyr Arg Asp Leu Tyr Ser Ser Gly Ala Asp Cys Leu Ala Arg 
    770                 775                 780                 


Leu Arg Pro Phe Ile Glu Gln Gly Ala Asp Ile Lys Asn Trp Ser Asp 
785                 790                 795                 800 


Leu Tyr Val Gln Thr Asp Lys Gln Thr Pro Val Ile His Ala Gly Ile 
                805                 810                 815     


Glu Leu Ser Val Lys Tyr Gly Thr Thr Ala Leu Leu Glu Gln Leu Ile 
            820                 825                 830         


Thr Cys Asn Pro Lys Phe Arg Val Met Glu Asp Asn Phe Thr Lys Trp 
        835                 840                 845             


Ser Ala Gln Lys Lys Glu Ile Glu Glu Lys Val Asn Lys His Thr Asn 
    850                 855                 860                 


Leu His Gln Gln Trp Val Glu Ala Lys Glu Lys Asp Asp Arg Glu Arg 
865                 870                 875                 880 


Val Lys Ser Lys Lys Asn Phe Val Arg Glu Tyr Val Lys Lys Asn Tyr 
                885                 890                 895     


Val Asp Tyr Ile Asn Asn Cys Ile Glu Ile Asn Asn Tyr Asn Trp Leu 
            900                 905                 910         


Asp Asn Lys Leu His Phe Val His Leu Asn His Leu His His Leu Thr 
        915                 920                 925             


Ile Asp Ile Leu Gly Arg Met Ala Gly Phe Val Ala Leu Trp Glu Arg 
    930                 935                 940                 


Asp Phe Gln Tyr Ile Thr Lys Tyr Thr Ala Ala Lys Glu Gly Thr Asp 
945                 950                 955                 960 


Ala Leu Ser Phe Asp Gly Gly Leu Pro Arg Leu Lys Asp Lys Gln Glu 
                965                 970                 975     


Tyr Tyr Asn Lys Leu Phe Leu Ser Asp Lys Tyr Thr Lys Val Arg Asn 
            980                 985                 990         


His Ile Ala His Phe Asn Tyr Leu  Thr Lys Asp Ala Ala  Asp Phe Ala 
        995                 1000                 1005             


Leu Leu  Asp Leu Ile Asn Glu  Leu Arg Glu Leu Leu  His Tyr Gly 
    1010                 1015                 1020             


Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ala Phe Ile  Asp Leu Phe 
    1025                 1030                 1035             


Glu Lys  His Gly Met Ile Leu  Lys Leu Lys Leu Asn  Thr Asp His 
    1040                 1045                 1050             


Gln Leu  Val Val Glu Ser Ile  Glu Pro Lys Lys Ile  Tyr His Leu 
    1055                 1060                 1065             


Gly Ser  Thr Ala Lys Asp Lys  Pro Glu Tyr Gln Tyr  Thr Thr Asn 
    1070                 1075                 1080             


Gln Val  Met Thr Val Tyr Cys  Asn Met Cys Arg Ser  Leu Leu Glu 
    1085                 1090                 1095             


Met Lys  Lys 
    1100     


<210>  391
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  391

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Leu Tyr Gln Ile Val  Ser Ala Phe Asn Phe  Gly Ser Lys 
    1205                 1210                 1215             


Leu Leu  Tyr Ile Ser Glu Asp  Gly Arg Trp Lys Met  Ala Gly Gly 
    1220                 1225                 1230             


Ala Phe  Pro Gly Lys Tyr Gly  Arg Phe Glu Asn Asp  Tyr Asn His 
    1235                 1240                 1245             


Arg Thr  Ser Leu Ser Lys Val  Ile Arg Leu Phe Glu  Asn Glu Ser 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ile Ile Tyr  Trp Arg Asp Tyr Val  Asp His Met 
    1265                 1270                 1275             


Lys Tyr  Tyr Val Asn Gln Asn  Gln Ser Ile Met Glu  Ile Tyr Ser 
    1280                 1285                 1290             


Ala Phe  Tyr Ser Lys Val Leu  Gly Tyr Ser Ala Lys  Leu Arg Lys 
    1295                 1300                 1305             


Ser Val  Val Phe Asn Leu Gln  Ala Ala Leu Glu Lys  His His Ile 
    1310                 1315                 1320             


Asn Pro  Glu Cys Ile Trp Met  Thr Ser Asp Gly Lys  Cys Ala Asp 
    1325                 1330                 1335             


Ile Lys  Leu Met Lys Asn Leu  Glu Ser Gln Lys Phe  Thr Tyr Lys 
    1340                 1345                 1350             


Leu Ala  Lys Arg Glu Gly Glu  Lys Thr Glu Arg Lys  Ile Cys Met 
    1355                 1360                 1365             


Asn Ala  Leu Asn Glu Asn Phe  Leu Lys Thr Ile Arg  Thr Ser Leu 
    1370                 1375                 1380             


Glu Tyr  Lys Lys 
    1385         


<210>  392
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  392

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  393
<211>  1383
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  393

Met Lys Leu Ser Lys Glu Lys Gln Ile Arg Ser Ala Val Ala Asn Lys 
1               5                   10                  15      


Glu Lys Asn Thr Glu Gly Val Leu Tyr Arg Phe Pro Gly Ala Asp Ile 
            20                  25                  30          


Gly Gly Val Gln Ala Gln Met Leu Val Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Leu Gly Asn Lys Pro Lys Glu 
    50                  55                  60                  


Trp Met Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Lys Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Ala Ile Asn Asp Ile Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Lys Glu Ala Asp Lys Lys Ile Arg Asn Met Ser Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Asn Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Gly Asn Gln Glu Phe Asp Ser Ile Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp Arg 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Asp Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Ser Ile Gln Asp Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Ile Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Glu Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Ala Glu Lys Asp Gly Leu Asn Glu Phe Met Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Glu Glu Lys Arg Ala Glu Val Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Ser His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Val Asn Lys Glu Lys Phe Tyr Val Trp 
305                 310                 315                 320 


Lys Lys His Glu Cys Gly Lys Lys Glu Asn Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Val Glu Ala Glu Ala Glu Ser Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Ile Phe Phe Glu Asn Asp Thr Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Thr Gly Thr Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Lys Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asn Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Gln Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Leu 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Arg Thr Leu Arg Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Leu Asp Trp Thr Ser Lys 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Glu Asn Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Ala Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Glu Asn Glu Leu His Val Asn Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Ile Gln Val Ile Glu Val Cys Leu Leu 
        915                 920                 925             


Leu Ser Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Lys Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Lys Phe Ser Glu Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Thr Asn Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Ser  Asp Ile Glu Glu Phe  Tyr Asn Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Val Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asn  Ser Glu Lys Lys Glu  Glu Tyr Lys Lys Ile  Gln Val Asn 
    1100                 1105                 1110             


Gly Asp  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Ile  Tyr Ala Pro Glu Lys  Asn Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Gln Gly Arg Val Gly  Ala Lys Val 
    1145                 1150                 1155             


Ile Ser  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Glu Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Met Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Val Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Val Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Glu Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asn Ala 
    1280                 1285                 1290             


Lys Asp  Lys Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Asp  Ala Glu Asp Ala Asp  Ser Lys Lys Pro Val  Ile Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Glu  Asp Glu Asp 
    1325                 1330                 1335             


Lys Gln  Lys Gly Lys Glu Arg  Lys Thr Gly Glu Arg  Lys Thr Gln 
    1340                 1345                 1350             


Lys Gln  Glu Val Met Arg Lys  Lys Ile Ile Met Ile  Val Tyr His 
    1355                 1360                 1365             


Ile Ile  Leu Leu Gln Thr Leu  Ile Leu Asn Tyr Gln  Ile Lys Ile 
    1370                 1375                 1380             


<210>  394
<211>  1225
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  394

Met Lys Ile Thr Lys Arg Lys Trp Gly Glu His His Pro Pro Leu Tyr 
1               5                   10                  15      


Phe Tyr Arg Asp Glu Asp Ser Gly Arg Leu Leu Ala Gln Asn Asp Arg 
            20                  25                  30          


Lys Gln Asp Tyr Thr Asp Thr Leu Phe Asn Asp Ile Ala Gln Asp Thr 
        35                  40                  45              


Phe Glu Arg Ser Leu Arg Asn Arg Leu Leu Lys Thr Pro Glu Lys Gly 
    50                  55                  60                  


Asp Lys Arg Phe Tyr Ser Asn Glu Ile Val Lys Leu Val Glu Lys Leu 
65                  70                  75                  80  


Cys Gln Gly Ala Asp Val Ala Glu Ile Met Lys Ser Met Glu Arg Ser 
                85                  90                  95      


Glu Lys Leu Arg Pro Lys Asn Glu Lys Glu Ile Lys Asn Leu Lys Lys 
            100                 105                 110         


Gln Leu Tyr Gly Thr Leu Ser Glu Tyr Gly Lys Arg Tyr Thr Ala Pro 
        115                 120                 125             


Glu Gly Ala Met Thr Leu Asn Asp Ala Leu Phe Tyr Leu Val Glu Gly 
    130                 135                 140                 


Asn Pro Leu Lys Gln Ala Met Ala Lys Ala Glu Leu Gly Lys Ile Arg 
145                 150                 155                 160 


Glu Ala Leu Ile Lys Glu Lys Glu Asn Arg Ile Asn Arg Val Arg Tyr 
                165                 170                 175     


Ser Ile Lys Asn Asn Lys Ile Pro Leu Arg Ile Gln Glu Asp Gly Gly 
            180                 185                 190         


Ile Thr Pro Asn Asn Asp Arg Ala Ala Trp Leu Leu Gly Leu Met Lys 
        195                 200                 205             


Pro Ala Asp Pro Ala Lys Gly Ile Thr Asp Cys Tyr Pro Leu Leu Gly 
    210                 215                 220                 


Glu Leu Glu Glu Val Phe Asp Phe Asp Lys Leu Ser Lys Thr Leu His 
225                 230                 235                 240 


Glu Lys Ile Ser Arg Cys Gln Gly Arg Pro Arg Ser Ile Ala Met Ala 
                245                 250                 255     


Val Asp Glu Ala Leu Lys Gln Tyr Leu Arg Glu Leu Trp Glu Lys Ser 
            260                 265                 270         


Pro Ser Arg Gln Gln Asp Leu Lys Tyr Tyr Phe Gln Ala Val Gln Glu 
        275                 280                 285             


Tyr Phe Lys Asp Asn Phe Pro Ile Arg Thr Lys Arg Met Gly Ala Arg 
    290                 295                 300                 


Leu Arg Gln Glu Leu Leu Lys Asp Lys Thr Ser Leu Ser Arg Leu Leu 
305                 310                 315                 320 


Glu Pro Lys His Met Ala Asn Ala Val Arg Arg Arg Leu Ile Asn Gln 
                325                 330                 335     


Ser Thr Gln Met His Ile Leu Tyr Gly Lys Leu Tyr Ala Tyr Cys Cys 
            340                 345                 350         


Gly Glu Asp Gly Arg Leu Leu Val Asn Ser Glu Thr Leu Gln Arg Ile 
        355                 360                 365             


Gln Val His Glu Ala Val Lys Lys Gln Ala Met Thr Ala Val Leu Trp 
    370                 375                 380                 


Ser Ile Ser Arg Leu Arg Tyr Phe Tyr Gln Phe Glu Asp Gly Asp Ile 
385                 390                 395                 400 


Leu Ser Asn Lys Asn Pro Ile Lys Asp Phe Arg Asp Lys Phe Leu Arg 
                405                 410                 415     


Asp Thr Asn Lys Tyr Thr His Glu Asp Val Glu Ala Cys Lys Glu Lys 
            420                 425                 430         


Leu Gln Asp Phe Phe Pro Leu Lys Glu Leu Gln Glu Lys Ile Lys Glu 
        435                 440                 445             


Asp Ala Lys Gly Leu Gln Glu Thr Asp Asn Lys Gln Ala Asp Thr Thr 
    450                 455                 460                 


Asp Phe Lys Ala Ile Gly His Ile Val Arg Asp Asp Arg Lys Leu Cys 
465                 470                 475                 480 


Asn Gln Leu Leu Ala Glu Cys Val Ser Cys Ile Gly Glu Leu Arg His 
                485                 490                 495     


His Ile Phe His Tyr Lys Asn Val Thr Leu Ile Gln Ala Leu Lys Arg 
            500                 505                 510         


Ile Ala Asp Lys Val Lys Pro Glu Asp Leu Ser Val Leu Arg Ala Ile 
        515                 520                 525             


Tyr Leu Leu Asp Arg Arg Asn Leu Lys Lys Ala Phe Ala Lys Arg Ile 
    530                 535                 540                 


Ser Ser Met Asn Leu Pro Leu Tyr Tyr Arg Glu Asp Leu Leu Ser Arg 
545                 550                 555                 560 


Ile Phe Lys Lys Glu Gly Thr Ala Phe Phe Leu Tyr Ser Ala Lys Ile 
                565                 570                 575     


Gln Met Thr Pro Ser Phe Gln Arg Val Tyr Glu Arg Gly Lys Asn Leu 
            580                 585                 590         


Arg Arg Glu Phe Glu Cys Glu Arg Met Lys Ala Glu Ala Ser Asn Gly 
        595                 600                 605             


Gln Asn Gly Gln Asp Gly Asp Arg Leu Lys Trp Phe Arg Gln Leu Ala 
    610                 615                 620                 


Ala Gly Asp Ser Ala Asp Thr His Phe Asn Trp Ala Val Glu Ala Tyr 
625                 630                 635                 640 


Ala Glu Ser Ala Ala Asp Val Glu Asn Asn Val Glu Phe Asp Thr Asp 
                645                 650                 655     


Val Asp Ala Gln Arg Ala Leu Arg Asn Leu Leu Leu Leu Ile Tyr Arg 
            660                 665                 670         


His His Phe Leu Pro Glu Val Gln Lys Asp Glu Thr Leu Val Thr Gly 
        675                 680                 685             


Lys Ile His Lys Val Leu Glu Arg Asn Arg Gln Leu Ser Glu Gly Gln 
    690                 695                 700                 


Gly Pro Asn Gln Gly Lys Ala His Gly Tyr Ser Val Ile Glu Glu Leu 
705                 710                 715                 720 


Tyr His Glu Gly Met Pro Leu Ser Asp Leu Met Lys Gln Leu Gln Arg 
                725                 730                 735     


Arg Ile Ser Glu Thr Glu Arg Glu Ser Arg Glu Leu Ala Gln Glu Lys 
            740                 745                 750         


Thr Asp Tyr Ala Gln Arg Phe Ile Leu Asp Ile Phe Ala Glu Ala Phe 
        755                 760                 765             


Asn Asp Phe Leu Glu Ala His Tyr Gly Glu Glu Tyr Leu Glu Ile Met 
    770                 775                 780                 


Ser Pro Arg Lys Asp Ala Glu Ala Ala Lys Lys Trp Val Lys Glu Ser 
785                 790                 795                 800 


Lys Thr Val Asp Leu Lys Thr Ser Ile Asp Glu Lys Glu Pro Glu Gly 
                805                 810                 815     


His Leu Leu Val Leu Tyr Pro Val Leu Arg Leu Leu Asp Glu Arg Glu 
            820                 825                 830         


Leu Gly Glu Leu Gln Gln Gln Met Ile Arg Tyr Arg Thr Ser Leu Ala 
        835                 840                 845             


Ser Trp Gln Gly Glu Ser Asn Phe Ser Glu Glu Ile Arg Ile Ala Gly 
    850                 855                 860                 


Gln Ile Glu Glu Leu Thr Glu Leu Val Lys Leu Thr Glu Pro Glu Pro 
865                 870                 875                 880 


Gln Phe Ala Glu Glu Val Trp Gly Lys Arg Ala Lys Glu Ala Phe Glu 
                885                 890                 895     


Asp Phe Ile Glu Gly Asn Met Lys Asn Tyr Glu Ala Phe Tyr Leu Gln 
            900                 905                 910         


Ser Asp Asn Asn Thr Pro Val Tyr Arg Arg Asn Met Ser Arg Leu Leu 
        915                 920                 925             


Arg Ser Gly Leu Met Gly Val Tyr Gln Lys Val Leu Ala Ser His Lys 
    930                 935                 940                 


Gln Ala Leu Lys Arg Asp Tyr Leu Leu Trp Ser Glu Lys His Trp Asn 
945                 950                 955                 960 


Val Lys Asp Glu Asn Gly Ala Asp Ile Ser Ser Ala Glu Gln Ala Gln 
                965                 970                 975     


Cys Leu Leu Gln Arg Leu His Arg Lys Tyr Ala Glu Ser Pro Ser Arg 
            980                 985                 990         


Phe Thr Glu Glu Asp Cys Lys Leu  Tyr Glu Lys Val Leu  Arg Arg Leu 
        995                 1000                 1005             


Glu Asp  Tyr Asn Gln Ala Val  Lys Asn Leu Ser Phe  Ser Ser Leu 
    1010                 1015                 1020             


Tyr Glu  Ile Cys Val Leu Asn  Leu Glu Ile Leu Ser  Arg Trp Val 
    1025                 1030                 1035             


Gly Phe  Val Gln Asp Trp Glu  Arg Asp Met Tyr Phe  Leu Leu Leu 
    1040                 1045                 1050             


Ala Trp  Val Arg Gln Gly Lys  Leu Asp Gly Ile Lys  Glu Glu Asp 
    1055                 1060                 1065             


Val Arg  Asp Ile Phe Ser Glu  Gly Asn Ile Ile Arg  Asn Leu Val 
    1070                 1075                 1080             


Asp Thr  Leu Lys Gly Glu Asn  Met Asn Ala Phe Glu  Ser Val Tyr 
    1085                 1090                 1095             


Phe Pro  Glu Asn Lys Gly Ser  Lys Tyr Leu Gly Val  Arg Asn Asp 
    1100                 1105                 1110             


Val Ala  His Leu Asp Leu Met  Arg Lys Asn Gly Trp  Arg Leu Glu 
    1115                 1120                 1125             


Ala Gly  Lys Thr Cys Ser Val  Met Glu Asp Tyr Ile  Asn Arg Leu 
    1130                 1135                 1140             


Arg Phe  Leu Leu Ser Tyr Asp  Gln Lys Arg Met Asn  Ala Val Thr 
    1145                 1150                 1155             


Lys Thr  Leu Gln Gln Ile Phe  Asp Arg His Lys Val  Lys Ile Arg 
    1160                 1165                 1170             


Phe Thr  Val Glu Lys Gly Gly  Met Leu Lys Ile Glu  Asp Val Thr 
    1175                 1180                 1185             


Ala Asp  Lys Ile Ala His Leu  Lys Gly Ser Arg Leu  Ser Gly Ile 
    1190                 1195                 1200             


Glu Ile  Leu Ser His Gly Glu  Arg Phe Ile Asp Thr  Leu Lys Ala 
    1205                 1210                 1215             


Leu Met  Val Tyr Pro Arg Gly  
    1220                 1225 


<210>  395
<211>  1225
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  395

Met Lys Ile Thr Lys Arg Lys Trp Gly Glu His His Pro Pro Leu Tyr 
1               5                   10                  15      


Phe Tyr Arg Asp Glu Asp Ser Gly Arg Leu Leu Ala Gln Asn Asp Arg 
            20                  25                  30          


Lys Gln Asp Tyr Thr Asp Thr Leu Phe Asn Asp Ile Ala Gln Asp Thr 
        35                  40                  45              


Phe Glu Arg Ser Leu Arg Asn Arg Leu Leu Lys Thr Pro Glu Lys Gly 
    50                  55                  60                  


Asp Lys Arg Phe Tyr Ser Asn Glu Ile Val Lys Leu Val Glu Lys Leu 
65                  70                  75                  80  


Cys Gln Gly Ala Asp Val Ala Glu Ile Met Lys Ser Met Glu Arg Ser 
                85                  90                  95      


Glu Lys Leu Arg Pro Lys Asn Glu Lys Glu Ile Lys Asn Leu Lys Lys 
            100                 105                 110         


Gln Leu Tyr Gly Thr Leu Ser Glu Tyr Gly Lys Arg Tyr Thr Ala Pro 
        115                 120                 125             


Glu Gly Ala Met Thr Leu Asn Asp Ala Leu Phe Tyr Leu Val Glu Gly 
    130                 135                 140                 


Asn Pro Leu Lys Gln Ala Met Ala Lys Ala Glu Leu Gly Lys Ile Arg 
145                 150                 155                 160 


Glu Ala Leu Ile Lys Glu Lys Glu Asn Arg Ile Asn Arg Val Arg Tyr 
                165                 170                 175     


Ser Ile Lys Asn Asn Lys Ile Pro Leu Arg Ile Gln Glu Asp Gly Gly 
            180                 185                 190         


Ile Thr Pro Asn Asn Asp Arg Ala Ala Trp Leu Leu Gly Leu Met Lys 
        195                 200                 205             


Pro Ala Asp Pro Ala Lys Gly Ile Thr Asp Cys Tyr Pro Leu Leu Gly 
    210                 215                 220                 


Glu Leu Glu Glu Val Phe Asp Phe Asp Lys Leu Ser Lys Thr Leu His 
225                 230                 235                 240 


Glu Lys Ile Ser Arg Cys Gln Gly Arg Pro Arg Ser Ile Ala Met Ala 
                245                 250                 255     


Val Asp Glu Ala Leu Lys Gln Tyr Leu Arg Glu Leu Trp Glu Lys Ser 
            260                 265                 270         


Pro Ser Arg Gln Gln Asp Leu Lys Tyr Tyr Phe Gln Ala Val Gln Glu 
        275                 280                 285             


Tyr Phe Lys Asp Asn Phe Pro Ile Arg Thr Lys Arg Met Gly Ala Arg 
    290                 295                 300                 


Leu Arg Gln Glu Leu Leu Lys Asp Lys Thr Ser Leu Ser Arg Leu Leu 
305                 310                 315                 320 


Glu Pro Lys His Met Ala Asn Ala Val Arg Arg Arg Leu Ile Asn Gln 
                325                 330                 335     


Ser Thr Gln Met His Ile Leu Tyr Gly Lys Leu Tyr Ala Tyr Cys Cys 
            340                 345                 350         


Gly Glu Asp Gly Arg Leu Leu Val Asn Ser Glu Thr Leu Gln Arg Ile 
        355                 360                 365             


Gln Val His Glu Ala Val Lys Lys Gln Ala Met Thr Ala Val Leu Trp 
    370                 375                 380                 


Ser Ile Ser Arg Leu Arg Tyr Phe Tyr Gln Phe Glu Asp Gly Asp Ile 
385                 390                 395                 400 


Leu Ser Asn Lys Asn Pro Ile Lys Asp Phe Arg Asp Lys Phe Leu Arg 
                405                 410                 415     


Asp Thr Asn Lys Tyr Thr His Glu Asp Val Glu Ala Cys Lys Glu Lys 
            420                 425                 430         


Leu Gln Asp Phe Phe Pro Leu Lys Glu Leu Gln Glu Lys Ile Lys Glu 
        435                 440                 445             


Asp Ala Lys Gly Leu Gln Glu Thr Asp Asn Lys Gln Ala Asp Thr Thr 
    450                 455                 460                 


Asp Phe Lys Ala Ile Gly His Ile Val Arg Asp Asp Arg Lys Leu Cys 
465                 470                 475                 480 


Asn Gln Leu Leu Ala Glu Cys Val Ser Cys Ile Gly Glu Leu Arg His 
                485                 490                 495     


His Ile Phe His Tyr Lys Asn Val Thr Leu Ile Gln Ala Leu Lys Arg 
            500                 505                 510         


Ile Ala Asp Lys Val Lys Pro Glu Asp Leu Ser Val Leu Arg Ala Ile 
        515                 520                 525             


Tyr Leu Leu Asp Arg Arg Asn Leu Lys Lys Ala Phe Ala Lys Arg Ile 
    530                 535                 540                 


Ser Ser Met Asn Leu Pro Leu Tyr Tyr Arg Glu Asp Leu Leu Ser Arg 
545                 550                 555                 560 


Ile Phe Lys Lys Glu Gly Thr Ala Phe Phe Leu Tyr Ser Ala Lys Ile 
                565                 570                 575     


Gln Met Thr Pro Ser Phe Gln Arg Val Tyr Glu Arg Gly Lys Asn Leu 
            580                 585                 590         


Arg Arg Glu Phe Glu Cys Glu Arg Met Lys Ala Glu Ala Ser Asn Gly 
        595                 600                 605             


Gln Asn Gly Gln Asp Gly Asp Arg Leu Lys Trp Phe Arg Gln Leu Ala 
    610                 615                 620                 


Ala Gly Asp Ser Ala Asp Thr His Phe Asn Trp Ala Val Glu Ala Tyr 
625                 630                 635                 640 


Ala Glu Ser Ala Ala Asp Val Glu Asn Asn Val Glu Phe Asp Thr Asp 
                645                 650                 655     


Val Asp Ala Gln Arg Ala Leu Arg Asn Leu Leu Leu Leu Ile Tyr Arg 
            660                 665                 670         


His His Phe Leu Pro Glu Val Gln Lys Asp Glu Thr Leu Val Thr Gly 
        675                 680                 685             


Lys Ile His Lys Val Leu Glu Arg Asn Arg Gln Leu Ser Glu Gly Gln 
    690                 695                 700                 


Gly Pro Asn Gln Gly Lys Ala His Gly Tyr Ser Val Ile Glu Glu Leu 
705                 710                 715                 720 


Tyr His Glu Gly Met Pro Leu Ser Asp Leu Met Lys Gln Leu Gln Arg 
                725                 730                 735     


Arg Ile Ser Glu Thr Glu Arg Glu Ser Arg Glu Leu Ala Gln Glu Lys 
            740                 745                 750         


Thr Asp Tyr Ala Gln Arg Phe Ile Leu Asp Ile Phe Ala Glu Ala Phe 
        755                 760                 765             


Asn Asp Phe Leu Glu Ala His Tyr Gly Glu Glu Tyr Leu Glu Ile Met 
    770                 775                 780                 


Ser Pro Arg Lys Asp Ala Glu Ala Ala Lys Lys Trp Val Lys Glu Ser 
785                 790                 795                 800 


Lys Thr Val Asp Leu Lys Thr Ser Ile Asp Glu Lys Glu Pro Glu Gly 
                805                 810                 815     


His Leu Leu Val Leu Tyr Pro Val Leu Arg Leu Leu Asp Glu Arg Glu 
            820                 825                 830         


Leu Gly Glu Leu Gln Gln Gln Met Ile Arg Tyr Arg Thr Ser Leu Ala 
        835                 840                 845             


Ser Trp Gln Gly Glu Ser Asn Phe Ser Glu Glu Ile Arg Ile Ala Gly 
    850                 855                 860                 


Gln Ile Glu Glu Leu Thr Glu Leu Val Lys Leu Thr Glu Pro Glu Pro 
865                 870                 875                 880 


Gln Phe Ala Glu Glu Val Trp Gly Lys Arg Ala Lys Glu Ala Phe Glu 
                885                 890                 895     


Asp Phe Ile Glu Gly Asn Met Lys Asn Tyr Glu Ala Phe Tyr Leu Gln 
            900                 905                 910         


Ser Asp Asn Asn Thr Pro Val Tyr Arg Arg Asn Met Ser Arg Leu Leu 
        915                 920                 925             


Arg Ser Gly Leu Met Gly Val Tyr Gln Lys Val Leu Ala Ser His Lys 
    930                 935                 940                 


Gln Ala Leu Lys Arg Asp Tyr Leu Leu Trp Ser Glu Lys His Trp Asn 
945                 950                 955                 960 


Val Lys Asp Glu Asn Gly Ala Asp Ile Ser Ser Ala Glu Gln Ala Gln 
                965                 970                 975     


Cys Leu Leu Gln Arg Leu His Arg Lys Tyr Ala Glu Ser Pro Ser Arg 
            980                 985                 990         


Phe Thr Glu Glu Asp Cys Lys Leu  Tyr Glu Lys Val Leu  Arg Arg Leu 
        995                 1000                 1005             


Glu Asp  Tyr Asn Gln Ala Val  Lys Asn Leu Ser Phe  Ser Ser Leu 
    1010                 1015                 1020             


Tyr Glu  Ile Cys Val Leu Asn  Leu Glu Ile Leu Ser  Arg Trp Val 
    1025                 1030                 1035             


Gly Phe  Val Gln Asp Trp Glu  Arg Asp Met Tyr Phe  Leu Leu Leu 
    1040                 1045                 1050             


Ala Trp  Val Arg Gln Gly Lys  Leu Asp Gly Ile Lys  Glu Glu Asp 
    1055                 1060                 1065             


Val Arg  Asp Ile Phe Ser Glu  Gly Asn Ile Ile Arg  Asn Leu Val 
    1070                 1075                 1080             


Asp Thr  Leu Lys Gly Glu Asn  Met Asn Ala Phe Glu  Ser Val Tyr 
    1085                 1090                 1095             


Phe Pro  Glu Asn Lys Gly Ser  Lys Tyr Leu Gly Val  Arg Asn Asp 
    1100                 1105                 1110             


Val Ala  His Leu Asp Leu Met  Arg Lys Asn Gly Trp  Arg Leu Glu 
    1115                 1120                 1125             


Ala Gly  Lys Thr Cys Ser Val  Met Glu Asp Tyr Ile  Asn Arg Leu 
    1130                 1135                 1140             


Arg Phe  Leu Leu Ser Tyr Asp  Gln Lys Arg Met Asn  Ala Val Thr 
    1145                 1150                 1155             


Lys Thr  Leu Gln Gln Ile Phe  Asp Arg His Lys Val  Lys Ile Arg 
    1160                 1165                 1170             


Phe Thr  Val Glu Lys Gly Gly  Met Leu Lys Ile Glu  Asp Val Thr 
    1175                 1180                 1185             


Ala Asp  Lys Ile Ala His Leu  Lys Gly Ser Arg Leu  Ser Gly Ile 
    1190                 1195                 1200             


Glu Ile  Leu Ser His Gly Glu  Arg Phe Ile Asp Thr  Leu Lys Ala 
    1205                 1210                 1215             


Leu Met  Val Tyr Pro Arg Gly  
    1220                 1225 


<210>  396
<211>  1385
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  396

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Lys Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn Gln Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Glu 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Ile Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Asn Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Val Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Phe Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Gln Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Arg Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Val Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asp Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Met Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Ile Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Cys Ile  Ser Ser Ile Lys Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Thr Leu Ile Thr Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Leu Leu Tyr  Tyr Pro Asp 
    1310                 1315                 1320             


Ile Glu  Ser Asn Val Lys Ile  Leu Leu Arg Lys Asp  Asn Phe Asn 
    1325                 1330                 1335             


Gln Asn  Lys Asp Lys Lys Asn  Val Asn Asn Arg Lys  Thr Lys Asn 
    1340                 1345                 1350             


Asn Asn  Lys Asn Gly Asn Arg  Asn Arg Asp Lys Asn  Ser Gly Gly 
    1355                 1360                 1365             


Asp Gly  Leu Thr Tyr Asn Pro  Phe Leu Asn Leu Ile  Phe Asp Leu 
    1370                 1375                 1380             


Pro Glu  
    1385 


<210>  397
<211>  1380
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  397

Met Lys Leu Ser Lys Glu Lys Gln Ile Arg Ser Ala Val Ala Asn Lys 
1               5                   10                  15      


Glu Lys Asn Thr Glu Gly Val Leu Tyr Arg Phe Pro Gly Asp Asp Ile 
            20                  25                  30          


Gly Gly Val Gln Ala Gln Met Leu Val Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Leu Gly Asn Lys Pro Lys Glu 
    50                  55                  60                  


Trp Met Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Lys Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Ala Ile Asn Asp Ile Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Lys Glu Ala Asp Lys Lys Ile Arg Asn Met Ser Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Asn Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Ser Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Gly Asn Gln Glu Phe Asp Ser Ile Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Asp Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Ser Ile Gln Asp Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Ile Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Glu Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Asp Gly Leu Asn Glu Phe Met Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Glu Glu Lys Arg Ala Glu Val Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Ser His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Val Asn Lys Gly Lys Phe Tyr Val Trp 
305                 310                 315                 320 


Lys Lys His Glu Cys Gly Lys Lys Glu Asn Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Val Glu Ala Glu Ala Glu Ser Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Ile Phe Phe Glu Asn Asp Thr Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Thr Gly Thr Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Lys Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asn Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Gln Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Leu 
            660                 665                 670         


Val Arg Thr Val Phe Pro Glu Tyr Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Asn Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Arg Thr Leu Arg Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Lys 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Glu Asn Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Cys Ala Gln Asp 
            900                 905                 910         


Ile Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu 
        915                 920                 925             


Leu Ser Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Lys Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Lys Phe Ser Glu Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Thr Asn Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Gly  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Glu Lys Pro Glu  Glu Tyr Glu Lys Ile  Glu Ala Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Ile  Tyr Ala Pro Glu Lys  Asn Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Gln Gly Arg Val Gly  Ala Lys Val 
    1145                 1150                 1155             


Thr Ser  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Glu Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Met Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Val Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Val Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Glu Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asn Ala 
    1280                 1285                 1290             


Lys Asp  Lys Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Asp  Ala Glu Asp Ala Asp  Ser Lys Lys Pro Val  Ile Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Glu  Asp Glu Asp 
    1325                 1330                 1335             


Lys Gln  Lys Gly Lys Glu Asn  Arg Gly Lys Lys Asn  Thr Glu Thr 
    1340                 1345                 1350             


Arg Ser  Asp Ala Glu Lys Asn  Asn Asn Glu Arg Leu  Ser Tyr Asn 
    1355                 1360                 1365             


Pro Phe  Ala Asn Phe Asp Phe  Lys Leu Pro Asn Lys  
    1370                 1375                 1380 


<210>  398
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  398

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Ile Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Phe Asp Phe Lys Leu  Leu Asn 
    1400                 1405                 1410         


<210>  399
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  399

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Ile Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Glu Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Phe Asp Phe Lys Leu  Leu Asn 
    1400                 1405                 1410         


<210>  400
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  400

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  401
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  401

Met Lys Ile Ser Lys Val Gly His Thr Arg Thr Ala Val Gly Val Thr 
1               5                   10                  15      


Glu Asn Lys Gly Pro Glu Gly Leu Leu Tyr Ile Asp Pro Ser Lys Lys 
            20                  25                  30          


Ala Val Ile Asp Pro Ile Glu Arg Val Lys Asp Arg Ile Arg Lys Ala 
        35                  40                  45              


Asn Asn Leu Tyr Ser Val Phe Gly Pro Val Asn Asp Glu Asn Asp Lys 
    50                  55                  60                  


Asn Arg Lys Asn Glu Val Ala Asp Thr Phe Asn Gly Ile Ile Lys Lys 
65                  70                  75                  80  


Tyr Thr Ser Arg Asn Arg Asp Lys Gly Ile Asn Ser Glu Arg Asp Lys 
                85                  90                  95      


Thr Ile Tyr Lys Leu Asp Ala Asp Arg Leu Ile Asp Asp Val Thr Tyr 
            100                 105                 110         


Gly Phe Lys Gly Phe Val Tyr Asp Asp Glu Thr Lys Lys Ser Ile Asp 
        115                 120                 125             


Glu Ala Leu Asn Val Leu Leu Lys Gly Thr Leu Arg Arg Glu Asp Thr 
    130                 135                 140                 


Lys Lys Ala Phe Glu Asn Leu Phe Glu Ala Cys Ile Pro Ser Ser Glu 
145                 150                 155                 160 


Gly Ser His Lys Glu Lys Val Glu Ala Asp Lys Asp Ser Ile Lys Ser 
                165                 170                 175     


Tyr Ile Val Glu Pro Ile Val Lys Asp Tyr Ser Lys Ser Lys Met Gln 
            180                 185                 190         


Lys Asn Thr Ile Glu Ser Leu Lys Lys Gln Asn Leu Val Val Gln Pro 
        195                 200                 205             


Val Ser Arg Gly Gly Asn Thr Thr Ile Leu Ala Pro Ala Ser Ser Asn 
    210                 215                 220                 


Asn Arg Arg Ser Ser Lys Asn Ser Val Arg Leu Thr Lys Ala Glu Glu 
225                 230                 235                 240 


Lys Glu Ala Leu Thr Ser Phe Leu Glu Met Phe Ala Thr Leu Ser Glu 
                245                 250                 255     


Glu Asp Arg Lys Asp Ser Leu Met Arg Leu Arg Arg Leu Ala Asp Leu 
            260                 265                 270         


Tyr Phe Tyr Gly Lys Asp Gly Val Ile Ala Asp Thr Phe Asp Val Trp 
        275                 280                 285             


Val Arg His Asn Glu Ala Lys Gln Asn Thr Ala Lys Ile Val Asp Tyr 
    290                 295                 300                 


Thr Arg Pro Asp Tyr Ser Val Tyr Lys Ile Gln Asp Asp Asp Pro Glu 
305                 310                 315                 320 


Asp Glu Val Lys Arg Lys Lys Lys Glu Lys Lys Ile Val Gln Lys Ala 
                325                 330                 335     


Glu Ser Gly Lys Leu Arg Asp Met Leu Arg Thr Arg Asn Met Glu Leu 
            340                 345                 350         


Phe Arg Thr Ser Phe Lys Ala Ile Asp Glu Asp Ser Asn Asn Leu Phe 
        355                 360                 365             


Phe Glu Asp Lys Asn Val Ser Lys Phe Phe Ile His His Ile Glu Gly 
    370                 375                 380                 


Glu Phe Glu Arg Ile Phe Ser Asn Gly Arg Ser Asp Asp Phe Arg Leu 
385                 390                 395                 400 


Glu Thr Gly Tyr Ile Ser Glu Lys Val Trp Lys Gly Leu Ile Asn Tyr 
                405                 410                 415     


Leu Ser Ile Lys Tyr Ile Ala Ile Gly Lys Ser Val Tyr Asn Phe Ala 
            420                 425                 430         


Met Asp Glu Leu Thr Lys Pro Asp Gly Asp Met Ser Phe Gly Arg Ile 
        435                 440                 445             


Asn Asp Ala Tyr Ile Lys Gly Ile Thr Ser Phe Glu Tyr Glu Lys Ile 
    450                 455                 460                 


Ser Ala Glu Glu Thr Leu Gln Arg Glu Thr Ala Val Tyr Val Ser Phe 
465                 470                 475                 480 


Ala Ser Asn His Leu Ser Arg Ala Val Val Lys Ala Asp Ser Asp Ile 
                485                 490                 495     


Asp Leu Met Asp Leu Lys Ile Ser Glu Asn Gln Asp Lys Leu Val Asp 
            500                 505                 510         


Lys Asn Leu Ile Thr Lys Ser Ile Leu Gln Phe Phe Gly Gly Lys Ser 
        515                 520                 525             


Ser Trp Glu Lys Phe Ser Thr Asp Leu Ser Ala Glu Gly Phe Asp Ser 
    530                 535                 540                 


Tyr Ala Phe Leu Asn Asp Ile Lys Thr Leu Ile Tyr Gln Leu Arg Asn 
545                 550                 555                 560 


Glu Ser Phe His Phe Lys Thr Glu Lys Lys Asn Thr Asp Ile Ser Asn 
                565                 570                 575     


Pro Asp Leu Ile Ser Asp Met Phe Glu Tyr Glu Cys Arg Lys Ala Cys 
            580                 585                 590         


Val Leu Glu Lys Gln Lys Phe Tyr Ser Asn Asn Leu Pro Leu Tyr Tyr 
        595                 600                 605             


Lys Asp Ala Asp Leu Asn Arg Val Leu Glu Lys Leu Tyr Ser Thr Tyr 
    610                 615                 620                 


Thr Asp Arg Lys Ser Gln Val Pro Ser Phe Glu Arg Val Met Lys Arg 
625                 630                 635                 640 


Gly Asp Phe Ser Glu Tyr Leu Arg Gln Gln Gly Ile Lys Pro Ala Leu 
                645                 650                 655     


Asp Asp Lys Asn Leu Lys Lys Phe Glu Ser Ala Val Tyr Tyr Leu Tyr 
            660                 665                 670         


Lys Gln Val Tyr Tyr Asn Asp Phe Leu Ala His Glu Lys Asp Ala Lys 
        675                 680                 685             


Asn Val Phe Ile Lys Asn Ile Arg Asp Met Lys Ile His Thr Glu Ile 
    690                 695                 700                 


Gly Arg Asn Gly Lys Ser Arg Thr Val Val Glu Asp Lys Pro Ile Glu 
705                 710                 715                 720 


Asp Phe Arg Asn Arg Val Leu Glu Leu Glu His Tyr Ser Leu Ser Glu 
                725                 730                 735     


Ile Cys Gln Met Ile Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Asn 
            740                 745                 750         


Ile Lys Lys Ser Gln Arg Asn Val Glu Ile Phe Lys His Tyr Gln Leu 
        755                 760                 765             


Gly Leu Tyr Lys Ala Leu Asn Glu Ala Leu Thr Ile Tyr Val Lys Asn 
    770                 775                 780                 


Asn Asn Ala Leu Tyr Gly Phe Ile Lys Glu Pro His Ile Asp Pro Asp 
785                 790                 795                 800 


Ala Glu Leu Glu Ser Val Glu Gln Phe Leu Pro Asp Tyr Thr Ser Ala 
                805                 810                 815     


Gln Tyr Glu Glu Leu Ile Lys Lys Val Ser Ala Ser His Glu Leu Lys 
            820                 825                 830         


Lys Trp Tyr Ile Met Thr Arg Phe Leu Asn Pro Lys Gln Thr Asn Gln 
        835                 840                 845             


Leu Val Gly Ala Leu Arg Ser Tyr Val Gln Tyr Val Asp Ser Ile Lys 
    850                 855                 860                 


Arg Arg Ala Ser Glu Thr Gly Asn Ala Leu Pro Lys Phe Glu Glu Ala 
865                 870                 875                 880 


Lys Pro Ile Asn Asp Ile Ile Gln Val Ile Asp Met Cys Thr Arg Ile 
                885                 890                 895     


Cys Gly Asn Thr Ser Asn Asn Leu Glu Asp Tyr Phe Glu Asp Asn Glu 
            900                 905                 910         


Asp Tyr Ala Asp Tyr Leu Glu Gln Phe Leu Asp Phe Glu Met Asp Glu 
        915                 920                 925             


Ser Arg Ser Asp Asn Lys Ala Ala Met Leu Gly Ala Phe Cys Glu Asp 
    930                 935                 940                 


Lys Ile Glu Gly Gln Arg Ile Glu Ile Tyr His Asp Gly Thr Asn Pro 
945                 950                 955                 960 


Ile Leu Asn Arg Asn Ile Val Leu Ala Lys Leu Tyr Gly Ala Thr Gly 
                965                 970                 975     


Val Val Ser Arg Ala Ile Pro Arg Val Asp Ser Asn Ile Ile Lys Glu 
            980                 985                 990         


Tyr Tyr Ser Ala Asp Lys Asp Ile  Glu Ser Tyr Arg Lys  Asp Gly Gly 
        995                 1000                 1005             


Cys Lys  Thr Ala Asp Gln Gln  Lys Arg Leu Lys Glu  Tyr Gln Glu 
    1010                 1015                 1020             


Leu Lys  Asn Arg Val Glu Phe  Arg Asp Val Val Asp  Tyr Ser Glu 
    1025                 1030                 1035             


Ile Ile  Asn Glu Leu Tyr Gly  Gln Leu Ile Asn Trp  Thr Tyr Leu 
    1040                 1045                 1050             


Arg Glu  Arg Asp Leu Met Tyr  Phe Gln Leu Gly Phe  His Tyr Met 
    1055                 1060                 1065             


Cys Leu  Asn Asn Asn Ser Glu  Lys Pro Asp Ala Tyr  Lys Lys Ile 
    1070                 1075                 1080             


Glu Leu  Val Asp Lys Thr Asp  Asn Ser Arg Cys Ile  Asn Gly Ala 
    1085                 1090                 1095             


Ile Leu  Tyr Gln Ile Val Ala  Met Tyr Thr Tyr Gly  Val Asp Leu 
    1100                 1105                 1110             


Tyr Tyr  Arg Gly His Lys Ala  Tyr Pro Asp Asp Lys  Lys Ser Arg 
    1115                 1120                 1125             


Asp Tyr  Thr Asp Lys Lys Asn  Lys Trp Glu Ala Phe  Thr Gly Gln 
    1130                 1135                 1140             


Ile Gly  Gln Arg Val Pro Met  Phe Ala Leu Tyr Ser  Gly Tyr Met 
    1145                 1150                 1155             


Asn Lys  Gly Asn Ser Asp Val  Tyr Arg Pro Thr Tyr  Asp Leu Tyr 
    1160                 1165                 1170             


Thr Ser  Gly Leu Glu Leu Phe  Glu Val Ile Asp Glu  His Asp Asp 
    1175                 1180                 1185             


Ile Ile  Lys Leu Arg Asn Tyr  Ile Asp His Phe Asn  Tyr Tyr Ala 
    1190                 1195                 1200             


Lys Arg  Asp Arg Ser Leu Leu  Gly Ile Tyr Ser Glu  Ile Phe Asp 
    1205                 1210                 1215             


Arg Phe  Phe Thr Tyr Asp Met  Lys Tyr Gln Lys Asn  Val Pro Asn 
    1220                 1225                 1230             


Ile Leu  Ser Asn Ile Leu Ala  Gly His Leu Leu Val  Pro Ser Phe 
    1235                 1240                 1245             


Val Phe  Glu Thr Gly Ser Lys  Met Val Gly Lys Thr  Thr Lys Ala 
    1250                 1255                 1260             


Cys Ala  Lys Ile Asp Leu Lys  Asn Lys Asn Gly Leu  Lys Pro Asp 
    1265                 1270                 1275             


Ser Phe  Thr Tyr Lys Leu Asp  Asp Asp Asp Arg Lys  Lys Val Lys 
    1280                 1285                 1290             


Gly Pro  Ser Lys Leu Met Gly  Tyr Val Glu Asn Val  Ile Arg Ile 
    1295                 1300                 1305             


Leu Tyr  Tyr Ser Glu Gly Gly  Glu Thr Pro Glu Ile  Glu Leu Ser 
    1310                 1315                 1320             


Glu Gly  Tyr Tyr Lys Phe Ser  Gly Glu Ser Ser Val  Ala Lys Asp 
    1325                 1330                 1335             


Lys Thr  Ser Ser Lys Asn Asn  Asn Gly Arg Lys Met  Ser Ser Gly 
    1340                 1345                 1350             


Asn Gly  Arg Lys Pro Ser Asn  Asn Lys Gly Gly Asn  Ser Ser Ser 
    1355                 1360                 1365             


Tyr Arg  Asn Asn Asn Ser Ser  Gly Gly Leu Thr Ser  Thr Pro Phe 
    1370                 1375                 1380             


Asp Ala  Phe Phe 
    1385         


<210>  402
<211>  1380
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  402

Met Lys Leu Ser Lys Glu Lys Gln Ile Arg Ser Ala Val Ala Asn Lys 
1               5                   10                  15      


Glu Lys Asn Thr Glu Gly Val Leu Tyr Arg Phe Pro Gly Asp Asp Ile 
            20                  25                  30          


Gly Gly Val Gln Ala Gln Met Leu Val Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Leu Gly Asn Lys Pro Lys Glu 
    50                  55                  60                  


Trp Met Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Lys Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Ala Ile Asn Asp Ile Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Lys Glu Ala Asp Lys Lys Ile Arg Asn Met Ser Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Asn Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Ser Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Gly Asn Gln Glu Phe Asp Ser Ile Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Asp Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Ser Ile Gln Asp Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Ile Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Glu Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Asp Gly Leu Asn Glu Phe Met Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Glu Glu Lys Arg Ala Glu Val Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Ser His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Val Asn Lys Gly Lys Phe Tyr Val Trp 
305                 310                 315                 320 


Lys Lys His Glu Cys Gly Lys Lys Glu Asn Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Val Glu Ala Glu Ala Glu Ser Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Ile Phe Phe Glu Asn Asp Thr Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Thr Gly Thr Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Lys Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asn Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Gln Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Leu 
            660                 665                 670         


Val Arg Thr Val Phe Pro Glu Tyr Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Asn Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Arg Thr Leu Arg Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Lys 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Glu Asn Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Cys Ala Gln Asp 
            900                 905                 910         


Ile Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu 
        915                 920                 925             


Leu Ser Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Lys Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Lys Phe Ser Glu Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Thr Asn Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Gly  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Glu Lys Pro Glu  Glu Tyr Glu Lys Ile  Glu Ala Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Ile  Tyr Ala Pro Glu Lys  Asn Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Gln Gly Arg Val Gly  Ala Lys Val 
    1145                 1150                 1155             


Thr Ser  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Glu Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Met Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Val Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Val Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Glu Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asn Ala 
    1280                 1285                 1290             


Lys Asp  Lys Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Asp  Ala Glu Asp Ala Asp  Ser Lys Lys Pro Val  Ile Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Glu  Asp Glu Asp 
    1325                 1330                 1335             


Lys Gln  Lys Gly Lys Glu Asn  Arg Gly Lys Lys Asn  Thr Glu Thr 
    1340                 1345                 1350             


Arg Ser  Asp Ala Glu Lys Asn  Asn Asn Glu Arg Leu  Ser Tyr Asn 
    1355                 1360                 1365             


Pro Phe  Ala Asn Phe Asp Phe  Lys Leu Pro Asn Lys  
    1370                 1375                 1380 


<210>  403
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  403

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Asp Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Thr 
        115                 120                 125             


Lys Asp Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His 
            180                 185                 190         


Glu Arg Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Glu Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Arg 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Lys 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Thr Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Phe Asp Phe Lys Leu  Leu Asn 
    1370                 1375                 1380         


<210>  404
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  404

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Asp Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Thr 
        115                 120                 125             


Lys Asp Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His 
            180                 185                 190         


Glu Arg Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Glu Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Arg 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Lys 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Thr Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Phe Asp Phe Lys Leu  Leu Asn 
    1370                 1375                 1380         


<210>  405
<211>  1380
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  405

Met Lys Leu Ser Lys Glu Lys Gln Ile Arg Ser Ala Val Ala Asn Lys 
1               5                   10                  15      


Glu Lys Asn Thr Glu Gly Val Leu Tyr Arg Phe Pro Gly Asp Asp Ile 
            20                  25                  30          


Gly Gly Val Gln Ala Gln Met Leu Val Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Leu Gly Asn Lys Pro Lys Glu 
    50                  55                  60                  


Trp Met Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Lys Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Ala Ile Asn Asp Ile Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Lys Glu Ala Asp Lys Lys Ile Arg Asn Met Ser Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Asn Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Ser Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Gly Asn Gln Glu Phe Asp Ser Ile Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Asp Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Ser Ile Gln Asp Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Ile Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Glu Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Asp Gly Leu Asn Glu Phe Met Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Glu Glu Lys Arg Ala Glu Val Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Ile His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Val Asn Lys Gly Lys Phe Tyr Val Trp 
305                 310                 315                 320 


Lys Lys His Glu Cys Gly Lys Lys Glu Asn Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Val Glu Ala Glu Ala Glu Ser Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Ile Phe Phe Glu Asn Asp Thr Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Thr Gly Thr Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Lys Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asn Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Gln Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Leu 
            660                 665                 670         


Val Arg Thr Val Phe Pro Glu Tyr Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Asn Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Arg Thr Leu Arg Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Lys 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Glu Asn Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Cys Ala Gln Asp 
            900                 905                 910         


Ile Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu 
        915                 920                 925             


Leu Ser Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Lys Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Lys Phe Ser Glu Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Thr Asn Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Gly  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Glu Lys Pro Glu  Glu Tyr Glu Lys Ile  Glu Ala Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Ile  Tyr Ala Pro Glu Lys  Asn Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Gln Gly Arg Val Gly  Ala Lys Val 
    1145                 1150                 1155             


Thr Ser  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Glu Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Met Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Val Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Val Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Glu Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asn Ala 
    1280                 1285                 1290             


Lys Asp  Lys Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Asp  Ala Glu Asp Ala Asp  Ser Lys Lys Pro Val  Ile Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Glu  Asp Glu Asp 
    1325                 1330                 1335             


Lys Gln  Lys Gly Lys Glu Asn  Arg Gly Lys Lys Asn  Thr Glu Thr 
    1340                 1345                 1350             


Arg Ser  Asp Ala Glu Lys Asn  Asn Asn Glu Arg Leu  Ser Tyr Asn 
    1355                 1360                 1365             


Pro Phe  Ala Asn Phe Asp Phe  Lys Leu Pro Asn Lys  
    1370                 1375                 1380 


<210>  406
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  406

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Thr Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Asp Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val His Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1400                 1405                 1410         


<210>  407
<211>  1380
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  407

Met Lys Leu Ser Lys Glu Lys Gln Ile Arg Ser Ala Val Ala Asn Lys 
1               5                   10                  15      


Glu Lys Asn Thr Glu Gly Val Leu Tyr Arg Phe Pro Gly Asp Asp Ile 
            20                  25                  30          


Gly Gly Val Gln Ala Gln Met Leu Val Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Leu Gly Asn Lys Pro Lys Glu 
    50                  55                  60                  


Trp Met Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Lys Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Ala Ile Asn Asp Ile Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Lys Glu Ala Asp Lys Lys Ile Arg Asn Met Ser Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Asn Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Ser Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Gly Asn Gln Glu Phe Asp Ser Ile Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Asp Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Ser Ile Gln Asp Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Ile Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Glu Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Asp Gly Leu Asn Glu Phe Met Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Glu Glu Lys Arg Ala Glu Val Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Ser His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Val Asn Lys Gly Lys Phe Tyr Val Trp 
305                 310                 315                 320 


Lys Lys His Glu Cys Gly Lys Lys Glu Asn Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Val Glu Ala Glu Ala Glu Ser Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Ile Phe Phe Glu Asn Asp Thr Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Thr Gly Thr Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Lys Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asn Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Gln Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Leu 
            660                 665                 670         


Val Arg Thr Val Phe Pro Glu Tyr Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Asn Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Arg Thr Leu Arg Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Lys 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Glu Asn Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Cys Ala Gln Asp 
            900                 905                 910         


Ile Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu 
        915                 920                 925             


Leu Ser Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Lys Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Lys Phe Ser Glu Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Thr Asn Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Gly  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Glu Lys Pro Glu  Glu Tyr Glu Lys Ile  Glu Ala Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Ile  Tyr Ala Pro Glu Lys  Asn Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Gln Gly Arg Val Gly  Ala Lys Val 
    1145                 1150                 1155             


Thr Ser  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Glu Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Met Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Val Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Val Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Glu Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asn Ala 
    1280                 1285                 1290             


Lys Asp  Lys Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Asp  Ala Glu Asp Ala Asp  Ser Lys Lys Pro Val  Ile Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Glu  Asp Glu Asp 
    1325                 1330                 1335             


Lys Gln  Lys Gly Lys Glu Asn  Arg Gly Lys Lys Asn  Thr Glu Thr 
    1340                 1345                 1350             


Arg Ser  Asp Ala Glu Lys Asn  Asn Asn Glu Arg Leu  Ser Tyr Asn 
    1355                 1360                 1365             


Pro Phe  Ala Asn Phe Asp Phe  Lys Leu Pro Asn Lys  
    1370                 1375                 1380 


<210>  408
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  408

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  409
<211>  1380
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  409

Met Lys Leu Ser Lys Glu Lys Gln Ile Arg Ser Ala Val Ala Asn Lys 
1               5                   10                  15      


Glu Lys Asn Thr Glu Gly Val Leu Tyr Arg Phe Pro Gly Asp Asp Ile 
            20                  25                  30          


Gly Gly Val Gln Ala Gln Met Leu Val Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Leu Gly Asn Lys Pro Lys Glu 
    50                  55                  60                  


Trp Met Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Lys Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Ala Ile Asn Asp Ile Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Lys Glu Ala Asp Lys Lys Ile Arg Asn Met Ser Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Asn Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Ser Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Gly Asn Gln Glu Phe Asp Ser Ile Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Asp Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Ser Ile Gln Asp Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Ile Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Glu Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Asp Gly Leu Asn Glu Phe Met Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Glu Glu Lys Arg Ala Glu Val Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Ser His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Val Asn Lys Gly Lys Phe Tyr Val Trp 
305                 310                 315                 320 


Lys Lys His Glu Cys Gly Lys Lys Glu Asn Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Val Glu Ala Glu Ala Glu Ser Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Ile Phe Phe Glu Asn Asp Thr Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Thr Gly Thr Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Lys Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asn Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Gln Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Leu 
            660                 665                 670         


Val Arg Thr Val Phe Pro Glu Tyr Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Asn Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Arg Thr Leu Arg Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Lys 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Glu Asn Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Cys Ala Gln Asp 
            900                 905                 910         


Ile Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu 
        915                 920                 925             


Leu Ser Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Lys Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Lys Phe Ser Glu Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Thr Asn Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Gly  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Glu Lys Pro Glu  Glu Tyr Glu Lys Ile  Glu Ala Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Ile  Tyr Ala Pro Glu Lys  Asn Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Gln Gly Arg Val Gly  Ala Lys Val 
    1145                 1150                 1155             


Thr Ser  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Glu Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Met Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Val Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Val Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Glu Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asn Ala 
    1280                 1285                 1290             


Lys Asp  Lys Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Asp  Ala Glu Asp Ala Asp  Ser Lys Lys Pro Val  Ile Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Glu  Asp Glu Asp 
    1325                 1330                 1335             


Lys Gln  Lys Gly Lys Glu Asn  Arg Gly Lys Lys Asn  Thr Glu Thr 
    1340                 1345                 1350             


Arg Ser  Asp Ala Glu Lys Asn  Asn Asn Glu Arg Leu  Ser Tyr Asn 
    1355                 1360                 1365             


Pro Phe  Ala Asn Phe Asp Phe  Lys Leu Pro Asn Lys  
    1370                 1375                 1380 


<210>  410
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  410

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Leu Tyr Gln Ile Val  Ser Ala Phe Asn Phe  Gly Ser Lys 
    1205                 1210                 1215             


Leu Leu  Tyr Ile Ser Glu Asp  Gly Arg Trp Lys Met  Ala Gly Gly 
    1220                 1225                 1230             


Ala Phe  Pro Gly Lys Tyr Gly  Arg Phe Glu Asn Asp  Tyr Asn His 
    1235                 1240                 1245             


Arg Thr  Ser Leu Ser Lys Val  Ile Arg Leu Phe Glu  Asn Glu Ser 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ile Ile Tyr  Trp Arg Asp Tyr Val  Asp His Met 
    1265                 1270                 1275             


Lys Tyr  Tyr Val Asn Gln Asn  Gln Ser Ile Met Glu  Ile Tyr Ser 
    1280                 1285                 1290             


Ala Phe  Tyr Ser Lys Val Leu  Gly Tyr Ser Ala Lys  Leu Arg Lys 
    1295                 1300                 1305             


Ser Val  Val Phe Asn Leu Gln  Ala Ala Leu Glu Lys  His His Ile 
    1310                 1315                 1320             


Asn Pro  Glu Cys Ile Trp Met  Thr Ser Asp Gly Lys  Cys Ala Asp 
    1325                 1330                 1335             


Ile Lys  Leu Met Lys Asn Leu  Glu Ser Gln Lys Phe  Thr Tyr Lys 
    1340                 1345                 1350             


Leu Ala  Lys Arg Glu Gly Glu  Lys Thr Glu Arg Lys  Ile Cys Met 
    1355                 1360                 1365             


Asn Ala  Leu Asn Glu Asn Phe  Leu Lys Thr Ile Arg  Thr Ser Leu 
    1370                 1375                 1380             


Glu Tyr  Lys Lys 
    1385         


<210>  411
<211>  1071
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  411

Met Leu Glu Arg Asp Lys Ala Val Lys Ser Leu Tyr Asn Ile Phe Asn 
1               5                   10                  15      


Gln Ile Gln Leu Gly Asn Glu Pro Lys Glu Trp Lys Glu Asn Arg Asn 
            20                  25                  30          


Leu Ser Thr Glu Glu Asn Thr Arg Arg Met His Gln Lys Glu Val Lys 
        35                  40                  45              


Ile Gln Asn Tyr Lys Met Lys Lys Ala Cys Ser Arg Tyr Val Asn Thr 
    50                  55                  60                  


Ile Ser Arg Thr Ile Asn Glu Leu Leu Phe Phe Tyr Lys Ile Thr Lys 
65                  70                  75                  80  


Thr Thr Gln Asn Asn Lys Val Lys Tyr Asp Lys Leu Lys Met Met His 
                85                  90                  95      


Lys Asn Glu Asp Ile Ile Ser Lys Met Lys Asn Glu Asn Ile Leu Gln 
            100                 105                 110         


Gln Phe Lys Val Glu Gly Glu Asn Gly Lys Leu Glu Lys Gly Lys Leu 
        115                 120                 125             


Glu Asp Phe Val Thr Leu Ala Leu Arg Ser Ser Leu Val Val Ser Arg 
    130                 135                 140                 


Tyr Lys Gly Lys Asp Phe Asp Ser Val Ala Ala Val Ala Val Phe Leu 
145                 150                 155                 160 


Glu Asn Ile Gly Asn Asn Asn Ile Ser His Glu Asp Glu Arg Thr Ile 
                165                 170                 175     


Asn Ile Leu Leu Asp Leu Ile Arg Glu Asp Phe Thr Lys Leu Asn Pro 
            180                 185                 190         


Asn Ile Asp Asn Thr Met Gly Ala Arg Leu Ile Arg Ser Val Thr Asn 
        195                 200                 205             


Gln Asn Met Leu Val Gln Pro Gln Asn Asp Arg Phe Ser Phe Pro Cys 
    210                 215                 220                 


Val Asp Asp Ser Gly Lys Ser Lys Val Ser Asn Lys Asn Val Glu Lys 
225                 230                 235                 240 


Ser Gly Leu Asp Asn Phe Leu Leu Asp Tyr Ala Asn Leu Asp Lys Asp 
                245                 250                 255     


Ile Arg Glu Asn Tyr Leu Arg Lys Leu Arg Arg Ile Ile Asp Ile Tyr 
            260                 265                 270         


Phe Ser Ala Pro Ile Thr Tyr Gln Lys Asp Met Asp Val Ala Leu Ser 
        275                 280                 285             


Glu Val Val Val Lys Asp Lys Phe Asp Val Trp Lys Lys His Asn Glu 
    290                 295                 300                 


Gly Lys Lys Asp Ser Asn Thr Phe Val Lys Val Pro Glu Val Leu Ile 
305                 310                 315                 320 


Lys Ser Glu Arg Asp His Glu Lys Leu Asp Thr Val Ile Glu Lys Gln 
                325                 330                 335     


Ala Arg Lys Glu Leu Ala Asp Arg Val Arg Lys Gln Asn Met Thr Cys 
            340                 345                 350         


Tyr Arg Tyr Thr Gln Ala Val Val Lys Lys Tyr Asn Ala Lys Glu Ala 
        355                 360                 365             


Leu Phe Phe Glu Asn Asp Asp Ile Asn Gln Tyr Trp Ile His His Ile 
    370                 375                 380                 


Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ile Gly Thr Leu 
385                 390                 395                 400 


Phe Lys Leu His Asn Gly Tyr Leu Thr Glu Lys Val Trp Lys Asp Ala 
                405                 410                 415     


Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys Val Val Tyr 
            420                 425                 430         


Asn Phe Ala Leu Asp Asp Ile Trp Asn Asp Asn Lys Val Lys Arg Leu 
        435                 440                 445             


Gly Asp Ile Ser Glu Lys Ile Arg Ser Gly Ile Thr Ser Phe Glu Tyr 
    450                 455                 460                 


Glu Met Leu Lys Ala Gln Glu Thr Leu Gln Arg Glu Leu Ala Val Asn 
465                 470                 475                 480 


Val Ala Phe Ser Ala Asn Asn Leu Ala Arg Ala Val Cys Asn Met Ser 
                485                 490                 495     


Asp Leu Ser Asp Lys Thr Ser Asp Phe Leu Leu Trp Gln Pro Asp Asp 
            500                 505                 510         


Ile Asn Asn Lys Met Lys Lys Ser Thr Gly Asn Asp Glu Asp Asn Glu 
        515                 520                 525             


Lys Asn Lys Arg Ala Val Cys Ala Val Leu Gln Phe Phe Gly Gly Lys 
    530                 535                 540                 


Ser Leu Trp Asn Asp Val Asp Phe Glu Lys Ala Tyr Lys Asn Ala Gly 
545                 550                 555                 560 


Lys His Gly Tyr Gly Val Tyr Phe Ile Asn Asp Leu Arg Lys Ala Ile 
                565                 570                 575     


Phe Ala Ala Arg Asn Glu Ser Phe His Phe Lys Thr Ala Ser Val Asn 
            580                 585                 590         


Asn Glu Lys Trp Asn Val Glu Phe Leu Gly Arg Met Phe Glu Lys Glu 
        595                 600                 605             


Thr Glu Phe Cys Leu Asp Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn 
    610                 615                 620                 


Leu Pro Met Phe Tyr Lys Ser Ser Asn Leu Glu Lys Met Leu Asn His 
625                 630                 635                 640 


Phe Tyr Ser Lys Asn Ile Ser Arg Ala Ala Gln Val Leu Ser Tyr Asn 
                645                 650                 655     


Thr Val Phe Val Arg Lys Thr Phe Pro Glu Tyr Val Asn Asn Val Leu 
            660                 665                 670         


Lys Tyr Lys Lys Pro Gly Thr Asp Ala Glu Ile Leu Asp Lys Trp Tyr 
        675                 680                 685             


Ser Ala Cys Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu 
    690                 695                 700                 


Gln Ser Lys Asp Ala Phe Lys Tyr Phe Glu Asn Ala Val Tyr Asn Leu 
705                 710                 715                 720 


Asn Ser Lys Asn Ile Asn His Asp Ser Ser Gly Gln Lys Leu Ser Arg 
                725                 730                 735     


Asp Glu Met Lys Arg Lys Lys Ala Ala Glu Ser Phe Gln Arg Arg Phe 
            740                 745                 750         


Val Glu Ile Lys Arg Val Ser Asp Ser Ser Ile Ser Tyr Val Cys Gln 
        755                 760                 765             


Val Phe Met Thr Asp Tyr Asn Gln Gln Asn Asn Gln Asn Lys Lys Val 
    770                 775                 780                 


Arg Ser Ser Asn Asp Ser Leu Leu Asp Lys Pro Ile Tyr Gln His Phe 
785                 790                 795                 800 


Lys Met Leu Leu Lys Glu Thr Ile Lys Ser Ala Phe Ala Ala Tyr Leu 
                805                 810                 815     


Lys Asp Asn Asn Asn Lys Asp Leu Phe Gly Phe Ile Gly Glu Pro Leu 
            820                 825                 830         


Lys Ile Asn Lys Asn Asp Asp Val Lys Val Ile Lys Lys Glu Glu Phe 
        835                 840                 845             


Leu Pro Asp Trp Lys Ser Asp Lys Tyr Ser Leu Leu Ile Glu Lys Val 
    850                 855                 860                 


Lys Lys Ser Pro Lys Leu Gln Met Trp Tyr Ile Val Gly Lys Phe Leu 
865                 870                 875                 880 


Asn Ala Arg Ser Leu Asn Leu Met Ala Gly Ser Met Arg Ser Tyr Leu 
                885                 890                 895     


Gln Tyr Val Ser Asp Ile Asn Arg Arg Ala Asn Val Val Gly Asn Lys 
            900                 905                 910         


Leu His Val Glu Val Leu Asp Lys Asp Thr Val Lys Asp Trp Ile Gln 
        915                 920                 925             


Val Ile Glu Val Cys Leu Leu Leu Ala Ser Arg Thr Ser Asn Gln Phe 
    930                 935                 940                 


Asp Asp Tyr Phe Ile Asp Gly Asp Asp Tyr Ala Gly Tyr Leu Lys Ser 
945                 950                 955                 960 


Tyr Val Asp Phe Ser Asp Lys Asn Met Pro Ser Ala Tyr Ser Ala Leu 
                965                 970                 975     


Val Tyr Phe Ser Asp Gln Gly Lys Ile Asp Leu Tyr Ile Asp Pro Lys 
            980                 985                 990         


Asn Pro Lys Ile Asn Arg Asn Ile  Val Gln Ser Lys Leu  Phe Ala Ala 
        995                 1000                 1005             


Asp His  Ile Leu Gly Asn Gly  Gln Ile Val Gln Pro  Val Ser Lys 
    1010                 1015                 1020             


Asp Asp  Ile Val Glu Phe Tyr  Asn Leu Lys Ala Lys  Ile Ala Asp 
    1025                 1030                 1035             


Ser Lys  Ile Lys Gly Glu Asn  Ile Ser Glu Ile Glu  Gln Arg Asn 
    1040                 1045                 1050             


Ile Leu  Arg Tyr Gln Arg Leu  Lys Asn Lys Val Glu  Leu Arg Asp 
    1055                 1060                 1065             


Ile Val  Glu 
    1070     


<210>  412
<211>  1380
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  412

Met Lys Leu Ser Lys Glu Lys Gln Ile Arg Ser Ala Val Ala Asn Lys 
1               5                   10                  15      


Glu Lys Asn Thr Glu Gly Val Leu Tyr Arg Phe Pro Gly Asp Asp Ile 
            20                  25                  30          


Gly Gly Val Gln Ala Gln Met Leu Val Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Leu Gly Asn Lys Pro Lys Glu 
    50                  55                  60                  


Trp Met Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Lys Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Ala Ile Asn Asp Ile Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Lys Glu Ala Asp Lys Lys Ile Arg Asn Met Ser Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Asn Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Ser Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Gly Asn Gln Glu Phe Asp Ser Ile Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Asp Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Ser Ile Gln Asp Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Ile Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Glu Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Asp Gly Leu Asn Glu Phe Met Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Glu Glu Lys Arg Ala Glu Val Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Ser His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Val Asn Lys Gly Lys Phe Tyr Val Trp 
305                 310                 315                 320 


Lys Lys His Glu Cys Gly Lys Lys Glu Asn Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Val Glu Ala Glu Ala Glu Ser Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Ile Phe Phe Glu Asn Asp Thr Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Thr Gly Thr Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Lys Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asn Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Gln Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Leu 
            660                 665                 670         


Val Arg Thr Val Phe Pro Glu Tyr Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Asn Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Arg Thr Leu Arg Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Lys 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Glu Asn Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Cys Ala Gln Asp 
            900                 905                 910         


Ile Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu 
        915                 920                 925             


Leu Ser Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Lys Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Lys Phe Ser Glu Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Thr Asn Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Gly  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Glu Lys Pro Glu  Glu Tyr Glu Lys Ile  Glu Ala Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Ile  Tyr Ala Pro Glu Lys  Asn Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Gln Gly Arg Val Gly  Ala Lys Val 
    1145                 1150                 1155             


Thr Ser  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Glu Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Met Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Val Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Val Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Glu Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asn Ala 
    1280                 1285                 1290             


Lys Asp  Lys Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Asp  Ala Glu Asp Ala Asp  Ser Lys Lys Pro Val  Ile Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Glu  Asp Glu Asp 
    1325                 1330                 1335             


Lys Gln  Lys Gly Lys Glu Asn  Arg Gly Lys Lys Asn  Thr Glu Thr 
    1340                 1345                 1350             


Arg Ser  Asp Ala Glu Lys Asn  Asn Asn Glu Arg Leu  Ser Tyr Asn 
    1355                 1360                 1365             


Pro Phe  Ala Asn Phe Asp Phe  Lys Leu Pro Asn Lys  
    1370                 1375                 1380 


<210>  413
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  413

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Thr Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Lys Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Glu 
        755                 760                 765             


Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Lys Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Ile  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1400                 1405                 1410         


<210>  414
<211>  1380
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  414

Met Lys Leu Ser Lys Glu Lys Gln Ile Arg Ser Ala Val Ala Asn Lys 
1               5                   10                  15      


Glu Lys Asn Thr Glu Gly Val Leu Tyr Arg Phe Pro Gly Asp Asp Ile 
            20                  25                  30          


Gly Gly Val Gln Ala Gln Met Leu Val Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Leu Gly Asn Lys Pro Lys Glu 
    50                  55                  60                  


Trp Met Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Lys Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Ala Ile Asn Asp Ile Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Lys Glu Ala Asp Lys Lys Ile Arg Asn Met Ser Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Asn Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Ser Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Gly Asn Gln Glu Phe Asp Ser Ile Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Asp Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Ser Ile Gln Asp Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Ile Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Glu Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Asp Gly Leu Asn Glu Phe Met Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Glu Glu Lys Arg Ala Glu Val Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Ile His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Val Asn Lys Gly Lys Phe Tyr Val Trp 
305                 310                 315                 320 


Lys Lys His Glu Cys Gly Lys Lys Glu Asn Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Val Glu Ala Glu Ala Glu Ser Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Ile Phe Phe Glu Asn Asp Thr Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Thr Gly Thr Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Lys Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asn Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Gln Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Leu 
            660                 665                 670         


Val Arg Thr Val Phe Pro Glu Tyr Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Asn Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Arg Thr Leu Arg Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Lys 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Glu Asn Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Cys Ala Gln Asp 
            900                 905                 910         


Ile Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu 
        915                 920                 925             


Leu Ser Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Lys Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Lys Phe Ser Glu Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Thr Asn Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Gly  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Glu Lys Pro Glu  Glu Tyr Glu Lys Ile  Glu Ala Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Ile  Tyr Ala Pro Glu Lys  Asn Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Gln Gly Arg Val Gly  Ala Lys Val 
    1145                 1150                 1155             


Thr Ser  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Glu Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Met Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Val Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Val Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Glu Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asn Ala 
    1280                 1285                 1290             


Lys Asp  Lys Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Asp  Ala Glu Asp Ala Asp  Ser Lys Lys Pro Val  Ile Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Glu  Asp Glu Asp 
    1325                 1330                 1335             


Lys Gln  Lys Gly Lys Glu Asn  Arg Gly Lys Lys Asn  Thr Glu Thr 
    1340                 1345                 1350             


Arg Ser  Asp Ala Glu Lys Asn  Asn Asn Glu Arg Leu  Ser Tyr Asn 
    1355                 1360                 1365             


Pro Phe  Ala Asn Phe Asp Phe  Lys Leu Pro Asn Lys  
    1370                 1375                 1380 


<210>  415
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  415

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Thr Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Lys Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Glu 
        755                 760                 765             


Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Lys Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Ile  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1400                 1405                 1410         


<210>  416
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  416

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Leu Tyr Gln Ile Val  Ser Ala Phe Asn Phe  Gly Ser Lys 
    1205                 1210                 1215             


Leu Leu  Tyr Ile Ser Glu Asp  Gly Arg Trp Lys Met  Ala Gly Gly 
    1220                 1225                 1230             


Ala Phe  Pro Gly Lys Tyr Gly  Arg Phe Glu Asn Asp  Tyr Asn His 
    1235                 1240                 1245             


Arg Thr  Ser Leu Ser Lys Val  Ile Arg Leu Phe Glu  Asn Glu Ser 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ile Ile Tyr  Trp Arg Asp Tyr Val  Asp His Met 
    1265                 1270                 1275             


Lys Tyr  Tyr Val Asn Gln Asn  Gln Ser Ile Met Glu  Ile Tyr Ser 
    1280                 1285                 1290             


Ala Phe  Tyr Ser Lys Val Leu  Gly Tyr Ser Ala Lys  Leu Arg Lys 
    1295                 1300                 1305             


Ser Val  Val Phe Asn Leu Gln  Ala Ala Leu Glu Lys  His His Ile 
    1310                 1315                 1320             


Asn Pro  Glu Cys Ile Trp Met  Thr Ser Asp Gly Lys  Cys Ala Asp 
    1325                 1330                 1335             


Ile Lys  Leu Met Lys Asn Leu  Glu Ser Gln Lys Phe  Thr Tyr Lys 
    1340                 1345                 1350             


Leu Ala  Lys Arg Glu Gly Glu  Lys Thr Glu Arg Lys  Ile Cys Met 
    1355                 1360                 1365             


Asn Ala  Leu Asn Glu Asn Phe  Leu Lys Thr Ile Arg  Thr Ser Leu 
    1370                 1375                 1380             


Glu Tyr  Lys Lys 
    1385         


<210>  417
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  417

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Leu Tyr Gln Ile Val  Ser Ala Phe Asn Phe  Gly Ser Lys 
    1205                 1210                 1215             


Leu Leu  Tyr Ile Ser Glu Asp  Gly Arg Trp Lys Met  Ala Gly Gly 
    1220                 1225                 1230             


Ala Phe  Pro Gly Lys Tyr Gly  Arg Phe Glu Asn Asp  Tyr Asn His 
    1235                 1240                 1245             


Arg Thr  Ser Leu Ser Lys Val  Ile Arg Leu Phe Glu  Asn Glu Ser 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ile Ile Tyr  Trp Arg Asp Tyr Val  Asp His Met 
    1265                 1270                 1275             


Lys Tyr  Tyr Val Asn Gln Asn  Gln Ser Ile Met Glu  Ile Tyr Ser 
    1280                 1285                 1290             


Ala Phe  Tyr Ser Lys Val Leu  Gly Tyr Ser Ala Lys  Leu Arg Lys 
    1295                 1300                 1305             


Ser Val  Val Phe Asn Leu Gln  Ala Ala Leu Glu Lys  His His Ile 
    1310                 1315                 1320             


Asn Pro  Glu Cys Ile Trp Met  Thr Ser Asp Gly Lys  Cys Ala Asp 
    1325                 1330                 1335             


Ile Lys  Leu Met Lys Asn Leu  Glu Ser Gln Lys Phe  Thr Tyr Lys 
    1340                 1345                 1350             


Leu Ala  Lys Arg Glu Gly Glu  Lys Thr Glu Arg Lys  Ile Cys Met 
    1355                 1360                 1365             


Asn Ala  Leu Asn Glu Asn Phe  Leu Lys Thr Ile Arg  Thr Ser Leu 
    1370                 1375                 1380             


Glu Tyr  Lys Lys 
    1385         


<210>  418
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  418

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Thr Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Lys Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Glu 
        755                 760                 765             


Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Lys Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Ile  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1400                 1405                 1410         


<210>  419
<211>  1380
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  419

Met Lys Leu Ser Lys Glu Lys Gln Ile Arg Ser Ala Val Ala Asn Lys 
1               5                   10                  15      


Glu Lys Asn Thr Glu Gly Val Leu Tyr Arg Phe Pro Gly Asp Asp Ile 
            20                  25                  30          


Gly Gly Val Gln Ala Gln Met Leu Val Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Leu Gly Asn Lys Pro Lys Glu 
    50                  55                  60                  


Trp Met Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Lys Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Ala Ile Asn Asp Ile Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Lys Glu Ala Asp Lys Lys Ile Arg Asn Met Ser Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Asn Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Ser Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Gly Asn Gln Glu Phe Asp Ser Ile Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Asp Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Ser Ile Gln Asp Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Ile Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Glu Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Asp Gly Leu Asn Glu Phe Met Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Glu Glu Lys Arg Ala Glu Val Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Ile His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Val Asn Lys Gly Lys Phe Tyr Val Trp 
305                 310                 315                 320 


Lys Lys His Glu Cys Gly Lys Lys Glu Asn Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Val Glu Ala Glu Ala Glu Ser Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Ile Phe Phe Glu Asn Asp Thr Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Thr Gly Thr Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Lys Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asn Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Gln Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Leu 
            660                 665                 670         


Val Arg Thr Val Phe Pro Glu Tyr Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Asn Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Arg Thr Leu Arg Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Lys 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Glu Asn Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Cys Ala Gln Asp 
            900                 905                 910         


Ile Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu 
        915                 920                 925             


Leu Ser Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Lys Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Lys Phe Ser Glu Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Thr Asn Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Gly  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Glu Lys Pro Glu  Glu Tyr Glu Lys Ile  Glu Ala Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Ile  Tyr Ala Pro Glu Lys  Asn Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Gln Gly Arg Val Gly  Ala Lys Val 
    1145                 1150                 1155             


Thr Ser  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Glu Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Met Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Val Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Val Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Glu Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asn Ala 
    1280                 1285                 1290             


Lys Asp  Lys Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Asp  Ala Glu Asp Ala Asp  Ser Lys Lys Pro Val  Ile Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Glu  Asp Glu Asp 
    1325                 1330                 1335             


Lys Gln  Lys Gly Lys Glu Asn  Arg Gly Lys Lys Asn  Thr Glu Thr 
    1340                 1345                 1350             


Arg Ser  Asp Ala Glu Lys Asn  Asn Asn Glu Arg Leu  Ser Tyr Asn 
    1355                 1360                 1365             


Pro Phe  Ala Asn Phe Asp Phe  Lys Leu Pro Asn Lys  
    1370                 1375                 1380 


<210>  420
<211>  1391
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  420

Met Lys Ile Ser Lys Glu Gly His Lys Arg Met Ser Val Thr Leu Lys 
1               5                   10                  15      


Asn Glu Glu Val Gln Lys Asn Ala Ala Asp Lys Ala Glu Gly Gln Ile 
            20                  25                  30          


Leu Pro Leu Glu Lys Gly Gln Lys Leu Lys Thr Tyr Ile Gln Lys Arg 
        35                  40                  45              


Val Asp Ser Ser Lys Arg Leu Tyr Lys Val Leu Gly Pro Ser Ala Val 
    50                  55                  60                  


Ser Lys Leu Asn Val Ala Lys Ser Glu Ala Val Leu Lys Cys Phe Asn 
65                  70                  75                  80  


Asp Phe Met Lys Asn Ile Ile Asp Asn Asn Val Arg Val Lys Pro Ala 
                85                  90                  95      


Asp Lys Arg Asp Arg Thr Ala Val Asp Tyr Ile Gln Asn Arg Gly Phe 
            100                 105                 110         


Ser Ile Glu Val Arg Asp Gly Thr Lys Glu Asp Lys Ser Asn Glu Asn 
        115                 120                 125             


Arg Gly Lys Lys Lys Glu Gln Lys Glu Ile Lys Lys Pro Leu Ser Asp 
    130                 135                 140                 


Val Tyr Ile Asp Val Asp Glu Ala Phe Val His Glu Leu Thr Arg Leu 
145                 150                 155                 160 


His Leu Arg Gly Thr Leu Lys Lys Lys Ala Lys Ile Glu Lys Asp Gly 
                165                 170                 175     


Thr Gln Val Asp Ile Tyr Ile Pro Asp Ile Ile Glu Lys Leu Val Phe 
            180                 185                 190         


Ala Thr Thr His Gly Ser Gln Phe Asp Ser Leu Ile Ser Gln Ile Gly 
        195                 200                 205             


Glu Ala Glu Leu Thr Ala Cys Ile His Ile Ile Phe Met Asp Tyr Thr 
    210                 215                 220                 


Lys Glu Glu Gln Ile Lys Lys Ile Ala Lys Ser Ile Glu Asn Gln Asp 
225                 230                 235                 240 


Val Lys Val Gln Val Leu Gly Lys Gly Lys Asp Ala Arg Leu Gln Leu 
                245                 250                 255     


Ala Ser Ala Asp Asn Glu Lys Lys Lys Tyr Ile Phe Leu Phe Leu Glu 
            260                 265                 270         


Lys Phe Ala Cys Ala Ala Ser Glu Glu Glu Arg Asp Asn Leu Leu Arg 
        275                 280                 285             


Glu Phe Arg Glu Leu Ile Val Leu Phe Tyr Cys Gly Thr Val Pro Tyr 
    290                 295                 300                 


Glu Glu Ile Lys Glu Arg Lys Thr Arg Ile Pro Val Trp Asp Phe Ser 
305                 310                 315                 320 


Phe Leu Ser Lys Met Val Ser Asp Val Pro Leu Ser Phe Ser Gln Glu 
                325                 330                 335     


Cys Ser Glu Lys Leu Ala Glu Arg Glu Leu Leu Lys Ala Glu Thr Asp 
            340                 345                 350         


Leu Glu Arg Arg Lys Glu Asn Lys Leu Lys Ile Arg Asp Ile Asn Thr 
        355                 360                 365             


Glu Val Lys Arg Asn Leu Glu Arg Ile Val Ala Gln Arg Tyr Gln Glu 
    370                 375                 380                 


Gly Ile Lys Ile Leu Gly Asp Val Ser Gly Glu Glu Tyr Lys Glu Lys 
385                 390                 395                 400 


Arg Phe Trp Leu Glu Tyr Ile Glu Asn Asp Ala Glu Lys Val Leu Cys 
                405                 410                 415     


Ser Lys Lys Thr Leu Ser Glu Asn Lys Leu Asp Val Leu Trp Leu Cys 
            420                 425                 430         


Glu Asn Thr Trp Arg Ser Phe Leu Ser Phe Ile Cys Ser Lys Ala Val 
        435                 440                 445             


Asp Met Gly Lys Ala Val Tyr His Phe Ala Met Pro Asn Leu Glu Lys 
    450                 455                 460                 


Ile Glu Ser Gly Lys Pro Val Arg Ala Gly Glu Ile Lys Pro Gln Phe 
465                 470                 475                 480 


Arg Lys Gly Ile Thr Ser Phe Asp Tyr Glu Lys Ile Lys Ala Glu Glu 
                485                 490                 495     


Asn Leu Glu Arg Ser Phe Met Thr Ala Ile Ser Phe Ala Leu Asn Asn 
            500                 505                 510         


Phe Ser Ser Ala Val Cys Pro Pro Glu Thr Tyr Glu Lys Glu Gly Lys 
        515                 520                 525             


Glu Asp Ile Leu Phe Met Gly Asp Asp Ala Leu Gln Lys Glu Met Tyr 
    530                 535                 540                 


Pro Asn Ala Ser Trp Arg Ile Leu Gln Tyr Phe Gly Gly Ala Ser Gln 
545                 550                 555                 560 


Trp Lys Asp Ser Arg Phe Glu Glu Val Ser Asp Ser Gln Lys Ala Val 
                565                 570                 575     


Leu Ile Asn Glu Ser Phe Val Pro Glu Ile Arg Arg Ala Met Gln Leu 
            580                 585                 590         


Ile Arg Asn Ser Ala Phe His Tyr Ala Ala Ser Ala Ala Gln Ser Thr 
        595                 600                 605             


Leu Asp Ser Thr Ser Tyr Leu Val Glu Ile Phe Glu Arg Glu Lys Lys 
    610                 615                 620                 


Leu Ile Gly Ser Lys Tyr Arg Lys Lys Tyr Val Ser Asn Asn Val Pro 
625                 630                 635                 640 


Val Phe Tyr Lys Val Glu Asp Ile Asp His Leu Met Lys Ser Leu Tyr 
                645                 650                 655     


Gly Ser Gln Lys Val Leu Glu Ser Gln Ile Pro Ser Phe Arg Asn Val 
            660                 665                 670         


Ile Ser Arg Lys Ser Leu Pro Glu Leu Ile Asn Gln Tyr Phe Ile Ile 
        675                 680                 685             


Asn Gly Thr Pro Tyr Arg Lys Met Lys Asn Asp Val Ala Thr Ser Glu 
    690                 695                 700                 


Lys Phe His Ala Ala Leu Tyr Phe Val Leu Lys Glu Ile Tyr Tyr Asn 
705                 710                 715                 720 


Gly Phe Leu Gln Glu Asp Asn Leu Met Glu Arg Phe Met Asp Ser Phe 
                725                 730                 735     


His Asp Glu Leu Lys Glu Val Arg Asp Asn Thr Ser Lys Ala Ser Ala 
            740                 745                 750         


Lys Lys Val Lys Ala Met Glu Asn Phe Glu Glu Arg Ile Lys Glu Leu 
        755                 760                 765             


Arg Lys Gly Asn Lys Ser Leu Ser Phe Gly Glu Val Cys Gln Ala Ile 
    770                 775                 780                 


Met Thr Asp Tyr Asn Leu Gln Asn Asn Gln Lys Lys Val Arg Leu Asn 
785                 790                 795                 800 


Gly Lys Asp Asn Leu Pro Asp Glu Lys Tyr Lys His Phe Lys Met Leu 
                805                 810                 815     


Leu Leu Val Cys Leu Arg Arg Thr Phe Val Asp Tyr Leu Gln Lys Asp 
            820                 825                 830         


Val Glu Gly Glu Arg Phe Gly Cys Lys Phe Leu Lys Glu Pro Arg Leu 
        835                 840                 845             


Lys Glu Lys Ile Tyr Asp Asn Leu Thr Glu Glu Gln Phe Cys Asn Gly 
    850                 855                 860                 


Trp Gln Thr Asp Arg Tyr Asn Asn Leu Met Lys Gly Asp Ser Ser Tyr 
865                 870                 875                 880 


Asp Ser Trp Leu Ile Ser Trp Phe Ile Met Ala His Phe Met Thr Pro 
                885                 890                 895     


Lys His Leu Asn His Leu Arg Gly Glu Ile Lys Ser Tyr Leu Ser Tyr 
            900                 905                 910         


Val Gln Asn Ile Glu Arg Arg Arg Trp Asn Ala Thr Gly Ile Gln Ile 
        915                 920                 925             


Glu Asp Glu Lys Glu Lys Arg Lys Lys Tyr Glu Gln Val Leu Glu Val 
    930                 935                 940                 


Leu Glu Leu Ala Ala Glu Tyr Cys Gly Gln Val Ser Lys Glu Arg Thr 
945                 950                 955                 960 


Asp Tyr Tyr Glu Ser Glu Glu Glu Tyr Ala Arg His Ile Ser Arg Tyr 
                965                 970                 975     


Ile Ala Phe Asp Asp Ser Lys Ser Glu Arg Pro Leu Glu Glu Gln Leu 
            980                 985                 990         


Tyr Gly Phe Cys Asn Gln Lys Val  Ala Gly Gly Thr Ala  Asn Arg Ile 
        995                 1000                 1005             


Gly Ile  Phe Tyr Asp Gly Glu  Asn Pro Val Leu Asn  Arg Asn Val 
    1010                 1015                 1020             


Val Ile  Ala Lys Leu Tyr Gly  Thr Glu Gly Leu Leu  Ser Glu Cys 
    1025                 1030                 1035             


Leu Gln  Asp Asp Arg Val Thr  Lys Ala Asp Ile Glu  Lys Tyr Tyr 
    1040                 1045                 1050             


Lys Leu  Ala Asp Ser Asp Ser  Leu Lys Ala Val Phe  Lys Tyr Gly 
    1055                 1060                 1065             


Gly Cys  Lys Asn Gln Lys Gln  Glu Glu Glu Arg Arg  Glu Tyr Gln 
    1070                 1075                 1080             


Gln His  Lys Asn Arg Ile Glu  Leu Val Asp Ile Leu  Lys Tyr Ser 
    1085                 1090                 1095             


Asp Leu  Leu Asn Asp Phe Met  Ser Gln Leu Ile Ser  Trp Cys Tyr 
    1100                 1105                 1110             


Leu Arg  Glu Arg Asp Arg Met  Tyr Phe Gln Met Gly  Leu His Tyr 
    1115                 1120                 1125             


Ile Arg  Leu Tyr Tyr Gly Lys  Asn Ile Val Glu Lys  Asp Ser Arg 
    1130                 1135                 1140             


Phe Arg  Ile Leu Gln Ser Lys  Glu Val Arg Ala Gly  Gly Glu Arg 
    1145                 1150                 1155             


Gly Ile  His Leu Thr Asp Gly  Ala Ile Leu Tyr Gln  Leu Ala Ala 
    1160                 1165                 1170             


Ile Tyr  Thr Tyr Glu Tyr Pro  Val Tyr Ala Leu Asp  Glu Glu Gly 
    1175                 1180                 1185             


Asn Ala  Thr Val Ser Lys Lys  Ala Lys Ser Gly Ser  Thr Thr Ala 
    1190                 1195                 1200             


Asn Ser  Ile Thr Ala Phe Trp  Lys Glu Tyr Cys Glu  Gly Asp Ala 
    1205                 1210                 1215             


Ser Ala  Tyr Glu Met Gly Leu  Arg Leu Phe Glu Asn  Pro Ile Glu 
    1220                 1225                 1230             


Glu Gly  Glu Leu Ile Ser Phe  Arg Asn Tyr Ile Asp  His Phe Lys 
    1235                 1240                 1245             


Tyr Tyr  Ser Gln Arg Asp Arg  Ser Ile Leu Asp Leu  Tyr Ser Gln 
    1250                 1255                 1260             


Val Phe  Ala Thr Tyr Phe Arg  Asn Asp Lys Lys Leu  Lys Lys Ser 
    1265                 1270                 1275             


Val Thr  Phe Ile Phe Lys Asn  Ile Leu Ala Arg His  Phe Val Ile 
    1280                 1285                 1290             


Ala Lys  Thr Val Leu Asp Val  His Asp Glu Pro Lys  Lys Asp Lys 
    1295                 1300                 1305             


Arg Lys  Asp Lys Lys Asn Pro  Lys Ile Arg Thr Tyr  Lys Gln Ala 
    1310                 1315                 1320             


Glu Ile  Arg Ile Ala Glu Lys  Asp Gly Leu Glu Ser  Asp Val Thr 
    1325                 1330                 1335             


Ile His  Lys Tyr Thr Lys Glu  Asp Leu Asp Glu Ala  Tyr Lys Lys 
    1340                 1345                 1350             


Lys Ala  Glu Gly Asp Arg Asn  Ile Arg Val Pro Lys  Glu Gly Gly 
    1355                 1360                 1365             


Lys Tyr  Ser Ile Leu Leu Tyr  Asp Glu Ser Phe Ile  Glu Arg Leu 
    1370                 1375                 1380             


Tyr Arg  Ile Leu Asn Tyr His  Lys 
    1385                 1390     


<210>  421
<211>  1185
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  421

Met Arg Ile Ile Lys Pro Tyr Gly Arg Ser Val Val Glu Lys Ala Gly 
1               5                   10                  15      


Pro Gly Arg Leu Ala Arg Ala Val Ser Leu His Pro Asp Pro Ala Arg 
            20                  25                  30          


Gly Val Glu Leu Asp Asn Arg Lys Ser Val Val Glu Phe Ala Ala Ser 
        35                  40                  45              


His Asp Arg Leu Val Ile Ala Gln Trp Ile Ser Thr Ile Asp Lys Ile 
    50                  55                  60                  


Ala Arg Lys Pro Val Gly Glu Ala Ala Ala Thr Pro Gln Gln Ala Glu 
65                  70                  75                  80  


Phe Arg Arg Arg Leu Gly Asp Ala Ala Trp Thr Leu Ile Glu Arg Arg 
                85                  90                  95      


Ala Leu Leu Thr Gly Leu Asn Asp Pro Ala Val Lys Ala Arg Leu Arg 
            100                 105                 110         


Arg Leu Trp Glu Phe Lys Ile Ala Pro Tyr Lys Thr Ala Arg Ala Val 
        115                 120                 125             


Ala Lys Thr Gly Thr Arg Pro Pro Arg Leu Lys Gly Trp Trp Phe Arg 
    130                 135                 140                 


Arg Phe Ala Gly Asp Val Glu Glu Val Asp Lys Val Asp Ala Asp Ala 
145                 150                 155                 160 


Val Ala Leu Ala Ile His Glu His Leu Tyr Ser Ala Gln Tyr Gln Met 
                165                 170                 175     


Arg Val Asp Asp Arg Thr Arg Leu Ser Gly Leu Ile Ala Ala Arg Ala 
            180                 185                 190         


Glu Ser Ile Ala Gly Asn Val Leu Gln Pro His Ala Ala Ala Arg Asp 
        195                 200                 205             


Lys Asp Gly Gly Trp Ser Glu Asp Asp Gln Arg Arg Tyr Ala Ala Ala 
    210                 215                 220                 


Gly Asp Val Ala Arg Glu Ile Arg Ser Ala Ala Glu Ala Arg Glu Arg 
225                 230                 235                 240 


Gly Asp Gly Lys Ile Gly Pro Arg Arg Val Thr Ser Glu Val Ala Gly 
                245                 250                 255     


Ala Ala Leu Phe Glu His Tyr Ala Arg Leu Phe Arg Gly Ala Asp Gly 
            260                 265                 270         


Lys Ala Met Gly Val Ala Gln Ala Arg Asp Gln Glu Ser Gly Leu Phe 
        275                 280                 285             


Asn Leu His Met Ala Val Lys Asp Cys Tyr Ala Arg Ile Leu Lys Gly 
    290                 295                 300                 


His Gly Lys Asp Leu Ala Lys His Gly Glu Gly Arg Arg Arg Val Ser 
305                 310                 315                 320 


Thr Leu Leu Pro Pro Thr Ser Val Asp Leu Phe Arg Leu Leu Asp Ala 
                325                 330                 335     


Met Leu Asp Asn Arg Asp Leu Asn Ala Leu Val Arg Leu Gly Lys Val 
            340                 345                 350         


Ile His Tyr Glu Ser Ala Gly Ala Gly Val Asp Arg Pro Ala Asp Val 
        355                 360                 365             


Val Asp His Trp Pro Ala Asp Val Ala Asp Ser Asp Tyr Trp Thr Ser 
    370                 375                 380                 


Asp Gly Gln Ala Arg Ile Lys Arg Asn Glu Ala Leu Val Arg Val Trp 
385                 390                 395                 400 


Arg His Val Leu Ala Leu Ala Ser Arg Thr Leu Thr Asp Trp Ala Asp 
                405                 410                 415     


Pro Lys Gly Met Ile Gly Gly Asp Ile Leu Leu Lys Asp Ser Val Glu 
            420                 425                 430         


Thr Ala Ile Ala Asn Phe Asp Ala Glu Ser Tyr Lys Arg Lys Ile Glu 
        435                 440                 445             


Val Leu Phe Gly Gly Arg Ala Ala Leu Phe Asp Gly Asp Gly Asp Glu 
    450                 455                 460                 


Ala Phe Glu Lys Asp Val Leu Arg Phe Ala Leu His Gly Val Ala Ala 
465                 470                 475                 480 


Leu Arg Asn Ala Ala Phe His Phe Lys Gly Val Gly Gly Phe Ala Glu 
                485                 490                 495     


Ala Leu Lys Thr Leu Gly Pro Arg Gln Asp Pro Arg Val Thr Ala Ala 
            500                 505                 510         


Val Asp Gly Leu Trp Arg Thr Asp Glu Glu Gly Arg Gly Arg Arg Leu 
        515                 520                 525             


Leu Ala Thr Met Arg Gly Ala His Phe Glu Ser Phe Phe Asp Gln Arg 
    530                 535                 540                 


Gln Asn Arg Arg Leu Ala Gln Ala Leu Ser Arg Ala Ser Glu Glu Ser 
545                 550                 555                 560 


Leu Pro Leu Pro Arg Phe Ala Val Met Leu Arg Arg Ala Glu Asn Ala 
                565                 570                 575     


Trp Asp Arg Leu Gly Leu Pro Lys Thr Ala Asn Arg Ala Asp Leu Glu 
            580                 585                 590         


Ala Pro Ala Arg His Cys Gln Tyr Val Ala Leu Lys Leu Leu Tyr Glu 
        595                 600                 605             


Arg Pro Phe Arg Ala Trp Leu Ala Glu Arg Asp Ala Ala Thr Leu Asn 
    610                 615                 620                 


Arg Phe Ile Val Cys Ala Val Glu Arg Ala Thr Lys Ala Ala Arg Met 
625                 630                 635                 640 


Leu Asn Pro Gly Ala Ser Arg Glu Leu Ala Glu Ala Ile Thr Ala Lys 
                645                 650                 655     


Ala Ala Asp Leu Gly Arg Leu Gly Asn Asp Asp Ser Val Glu Asp Phe 
            660                 665                 670         


Phe Phe Arg Leu Ser Ala Glu Thr Ala Gly Glu Ala Arg Val Gln Arg 
        675                 680                 685             


Gly Tyr Glu Ser Asp Ala Glu Asn Ala Arg Ala Gln Ala Ser His Ile 
    690                 695                 700                 


Glu Asn Leu Lys Ala Asp Leu Val Ala Leu Ala Phe Arg Asp Tyr Leu 
705                 710                 715                 720 


Gln Lys Ala Asp Phe Glu Phe Ala Leu Lys Leu Arg Gly Asp Glu Pro 
                725                 730                 735     


Leu Pro Thr Lys Pro Met Cys Ala Leu Asp Glu Ala Asp Phe Val Glu 
            740                 745                 750         


Gly Glu Ala Ser Ser Ala Glu Pro Pro Cys Glu Leu Tyr Phe Leu Leu 
        755                 760                 765             


His Leu Val Pro Val Asp Glu Val Gly Lys Leu Leu His Gln Leu Arg 
    770                 775                 780                 


Lys Trp Gln Ile Leu Ala Pro Pro Ala Pro Ala Ala Thr Gly Gly Pro 
785                 790                 795                 800 


Thr Thr Ala Ala Thr Val Ala Glu Ile Arg Leu Ala Leu Glu Leu Tyr 
                805                 810                 815     


Leu Asp Met His Asp Ala Lys Phe Glu Gly Gly Ala Ala Leu Val Gly 
            820                 825                 830         


Val Glu Pro Phe Lys Arg Leu Phe Glu Gly Asp Gly Leu Phe Gly Arg 
        835                 840                 845             


Ile Phe Glu Arg Pro Ala Gly Asp Arg Pro Gly Ala Glu Asp Asp Arg 
    850                 855                 860                 


Arg Leu Pro Arg Arg Gly Leu Arg Glu Ile Met Arg Phe Gly His Leu 
865                 870                 875                 880 


Arg Pro Leu Leu Pro Ile Phe Asp Lys Gln Pro Ile Arg Ala Asp Glu 
                885                 890                 895     


Val Ala Ala Tyr Leu Asp Ala Glu Gln Val Pro Asp Gly Gly Lys Ser 
            900                 905                 910         


Glu Ile Ala Arg Arg Gln Glu Arg Arg Glu Ala Leu His Glu Lys Trp 
        915                 920                 925             


Ala Arg Arg Arg Arg Glu Phe Ser Asp Asp Asp Arg Arg Ala Tyr Glu 
    930                 935                 940                 


Glu Ala Leu Arg Phe Val Glu Glu His Arg His Arg Ala Ala Arg Val 
945                 950                 955                 960 


Thr Leu Thr Asp His Val Arg Leu His Arg Leu Leu Met Ala Val Leu 
                965                 970                 975     


Gly Arg Leu Val Asp Tyr Ser Gly Leu Trp Glu Arg Asp Leu Tyr Phe 
            980                 985                 990         


Val Ala Leu Ala Leu Ile His Gln  Ala Gly Arg Arg Leu  Asp Glu Ile 
        995                 1000                 1005             


Phe Ala  Ala Asp Gly Leu Ala  Met Leu Arg Glu Gly  Arg Val Val 
    1010                 1015                 1020             


Glu Ala  Leu Arg Lys Leu Ala  Asp Ile Asp Ala Ala  Arg Ala Ile 
    1025                 1030                 1035             


Ala Ala  Glu Val Lys Arg Arg  Phe Asp Gly Ala Pro  Asp Ala Ala 
    1040                 1045                 1050             


Ser Arg  Val Val Lys Ile Arg  Asn Ala Phe Ala His  Phe Asn Met 
    1055                 1060                 1065             


Leu Arg  Pro Lys Arg Gly Gly  Ala Thr Ala Ala Leu  Asp Leu Thr 
    1070                 1075                 1080             


Ala Ala  Val Asn Asp Gly Arg  Glu Leu Met Ala Tyr  Asp Arg Lys 
    1085                 1090                 1095             


Leu Lys  Asn Ala Val Ser Arg  Ser Ile Ala Glu Leu  Leu Glu Arg 
    1100                 1105                 1110             


Glu Gly  Leu Ala Val Ala Trp  Ser Val Asn Glu His  Arg Leu Glu 
    1115                 1120                 1125             


Ala Thr  Arg Val Ser Thr Arg  Gln Ala Ser His Leu  Ala Asn Ser 
    1130                 1135                 1140             


Gly Leu  Arg Glu Asp Leu His  Gly Ala Gly Tyr Val  Ala Thr Val 
    1145                 1150                 1155             


Ala Glu  Leu Phe Gly Arg Thr  Ala Ala Lys Pro Ala  Ala Pro Leu 
    1160                 1165                 1170             


Ala Arg  Arg Glu Asn Arg Thr  Ala Arg Gly Gly Arg  
    1175                 1180                 1185 


<210>  422
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  422

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Thr Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Lys Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Glu 
        755                 760                 765             


Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Lys Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Ile  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1400                 1405                 1410         


<210>  423
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  423

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Ile Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Phe Asp Phe Lys Leu  Leu Asn 
    1400                 1405                 1410         


<210>  424
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  424

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Thr Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Asp Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Ser Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val His Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Leu Asn 
    1400                 1405                 1410         


<210>  425
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  425

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Ile Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Phe Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Lys 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Asn Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Thr Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Arg Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1400                 1405                 1410         


<210>  426
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  426

Met Lys Leu Ser Lys Glu Lys Tyr Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Glu Tyr Ile Arg Ser Ala Val Ala Asn Glu Lys Gln 
        35                  40                  45              


Asn Ile Gly Gly Val Leu Tyr His Ala His Gly Thr Asp Thr Ile Asp 
    50                  55                  60                  


Leu Gln Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Gly Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Thr Asp Arg Val Arg Arg Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Ile Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Glu Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Tyr Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Leu Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Glu Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Ile Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Ile Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1400                 1405                 1410         


<210>  427
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  427

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Ile Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Leu Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Glu 
        755                 760                 765             


Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Arg Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Asp Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Ile Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1400                 1405                 1410         


<210>  428
<211>  1291
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  428

Leu Lys Ile Thr Lys Ile Asp Gly Tyr Glu Phe Arg Arg Asn Phe Lys 
1               5                   10                  15      


Gln Gly Ser Ile Val Lys Gly Asn Asp Glu Asn Ile Lys Ile Ser Asp 
            20                  25                  30          


Ile Pro His Cys Ser Leu Asp Ile Phe Leu Glu Lys Glu Leu Arg Arg 
        35                  40                  45              


Arg Leu Leu Lys Gly Leu Lys Gly Glu Tyr Lys Asn Lys Glu Lys Asn 
    50                  55                  60                  


Asp Lys Asp Val Lys Glu Ile Asn Asn Lys Arg Met Ala Val Lys Lys 
65                  70                  75                  80  


Ile Ile Lys Asn Ile Gly Val Lys Asn Cys Arg Ile Tyr Phe Tyr Tyr 
                85                  90                  95      


Lys Asn Val Arg Asn Ile Glu Lys Ala Val Glu Gln Leu Asn Asn Phe 
            100                 105                 110         


Asn Tyr Pro Glu Val Asn Thr Glu Gly Lys Lys Ile Thr Lys Glu Glu 
        115                 120                 125             


Ile Ile Ser Tyr Asn Phe Lys Lys Asn Ser Ile Leu Glu Lys Leu Lys 
    130                 135                 140                 


Phe Gln Lys Ile Ile Thr Arg Leu Met Ser Lys Lys Arg Leu Tyr Gly 
145                 150                 155                 160 


Gly Thr Ile Phe Ile Val Phe Lys Glu Asn Asn Cys Leu Leu Arg Asn 
                165                 170                 175     


Met Leu Asn Ile Glu Gly Leu Lys Lys Tyr Tyr Ala Gln Phe Gln Asn 
            180                 185                 190         


Lys Leu Gln Gly Ser Ile Asp Asn Asn Ile Ile Thr Lys Phe Asn Asn 
        195                 200                 205             


Glu Val Val Ile Lys Asp Arg Asn Ser Phe Lys Tyr Asn Leu Tyr Asn 
    210                 215                 220                 


Lys Leu Ile Leu Asn Asn Gly Glu Phe Glu Ala Gln Leu Asn Glu Tyr 
225                 230                 235                 240 


Arg Asn Lys Tyr Asp Leu Glu Lys Leu Leu Lys Val Ile Asn Phe Ile 
                245                 250                 255     


Leu Ser Cys Lys Ala Glu Cys Gln Asp Pro Glu Ile Ala Asp Ile Val 
            260                 265                 270         


Ser Tyr Ile Lys Glu Asn Thr Gln Ile Gly Gln Lys Asp Leu Lys Glu 
        275                 280                 285             


Asn Lys Glu Lys Ile Asn Asn Asp Lys Tyr Phe Lys Asn Arg Val Ile 
    290                 295                 300                 


Lys Lys Ser Leu Ile Gly Tyr Gln Arg Asn His Asp Glu Leu Gln Gln 
305                 310                 315                 320 


Ala Arg Lys Glu Lys Ser Gly Leu Asn Tyr Tyr Asp Glu Glu Val Ile 
                325                 330                 335     


Ala Tyr Phe Asn Lys Tyr Tyr Pro Pro Lys Lys Thr Lys Asn Lys Lys 
            340                 345                 350         


Lys Arg Ile Pro Ser Asn Ser Cys Thr Leu Glu Ile Asn Val Ser Ala 
        355                 360                 365             


Asp Gln Ile His Arg Lys Ile Thr Asn Ile Leu Lys Asn Lys Val Val 
    370                 375                 380                 


Asn Ala Ala Ile Lys Ser Gly Gln Leu Asn Glu Phe Met Thr Asn Asn 
385                 390                 395                 400 


Asn Lys Arg Ile Glu Glu Ile Thr Ser Arg Asp Ile Glu Ile Ile His 
                405                 410                 415     


Ile Gln Asp Val Phe Ser Arg Lys Leu Ser Ser Ser Ile Thr Tyr Ala 
            420                 425                 430         


Ala Asn Ala Phe Arg Asn Glu Val Phe Thr Lys Asp Met Lys Lys Tyr 
        435                 440                 445             


Leu Asn Ile Phe Gly Lys Asn Ser Ile Thr Val Asn Gly Tyr Glu Leu 
    450                 455                 460                 


Lys Ser Tyr Ile Gly Ile Asp Gly Ile Asp Lys Lys Ser Lys Asn Glu 
465                 470                 475                 480 


Glu Ile Lys Glu Tyr Leu Thr Thr Met Tyr Asn Leu Asn Lys Ser Lys 
                485                 490                 495     


Ser Leu Asp Gln Ile Asp Lys Phe Ile Glu Asp Leu Lys Lys Leu Gly 
            500                 505                 510         


Phe Asn Leu Lys Ala Leu Asn Asp Glu Asp Asp Trp Arg Lys Lys Ile 
        515                 520                 525             


Thr Ile Leu Lys Gly Phe Ile Asn Glu Tyr Pro Glu Tyr Cys Arg Lys 
    530                 535                 540                 


Tyr Lys Lys Ile Glu Asp Tyr Phe Asn Gly Gly Asp Phe Leu Val Gln 
545                 550                 555                 560 


Asp Ala Tyr Lys Asn Thr Ser Leu Asn Ile Ile Leu Glu Phe Leu Asp 
                565                 570                 575     


Glu Asn Gly Gln Leu Ser Lys Leu Arg Gly Glu Asn Ile Tyr Pro Phe 
            580                 585                 590         


Ile Arg Ala Ser Ile Tyr Ala Phe Arg Asn Thr Ser Phe His Tyr Lys 
        595                 600                 605             


Asn Thr Ile Glu Thr Gln Phe Ile Ser Lys Glu Glu Asn Gly Tyr Tyr 
    610                 615                 620                 


Glu Asp Tyr Lys Glu Ala Ile Asn Ser Leu Lys Glu Asp Leu Lys Ser 
625                 630                 635                 640 


Arg Ile Asn Asp Ile Pro Lys Ile Glu Ile His Lys Ala Tyr Ser Asn 
                645                 650                 655     


Ala Val Phe Arg Phe Phe Asp Glu Ala Lys Ile Leu Glu Phe Tyr Lys 
            660                 665                 670         


Glu Asn Asn Leu Phe Tyr Pro Lys Gln Asn Asn Lys Met Pro Ser Phe 
        675                 680                 685             


Lys Ser Ile Leu Lys Ser Tyr Tyr Gly Leu Lys Glu Ser Lys Leu Lys 
    690                 695                 700                 


Leu Gly Lys Asp Leu Leu Glu Gln Leu Val Ala Leu Asp Lys Leu Lys 
705                 710                 715                 720 


Gly Glu Ser Lys Asp Ile Ala Phe Lys Gln Ala Gln Lys Tyr Leu Leu 
                725                 730                 735     


Ile Lys Leu Tyr Asn Thr Lys Tyr Glu Glu Ile Leu Glu Lys Ile Lys 
            740                 745                 750         


Glu Leu Ser Ser Ser Tyr Tyr Asp Lys Lys Ile Ser Lys Ser Asn Asp 
        755                 760                 765             


Val Gly Asn Tyr Lys Asn Ile Arg Lys Ala Ile Lys Asn Phe Lys Thr 
    770                 775                 780                 


Glu Asn Asn Gln Lys Tyr Phe Leu Asn Leu Lys Ser Ala Val Gln Lys 
785                 790                 795                 800 


Asp Lys Glu Leu Ala Ile Leu Arg Gly Lys Glu Glu Gly Phe Ala Phe 
                805                 810                 815     


Asn Ile Glu Lys Glu Leu Thr Ala Arg Ala Phe Tyr Glu Val Ile Lys 
            820                 825                 830         


Lys Glu Glu Tyr Lys Phe Ile Phe Asn Ser Pro Arg Glu Glu Lys Asp 
        835                 840                 845             


Ile Lys Glu Ser Asp Ile Ile Lys Glu Tyr Glu Asn Asn Lys Val Glu 
    850                 855                 860                 


Leu Glu Lys Leu His Ile Asn Pro Ser Asn Asp Leu Ile Tyr Ala Phe 
865                 870                 875                 880 


Tyr Ala Met Cys Leu Met Leu Ser Lys Ala Arg Ile Ser Glu Leu Tyr 
                885                 890                 895     


Asn Asn Met Val Ser Tyr Gln Gln Ala Tyr Met Lys Leu Ala Asp Val 
            900                 905                 910         


Glu Lys Glu Asp Ile Lys Ile Tyr Glu Asn Asn Asn His Phe Ile Met 
        915                 920                 925             


Ile Asp Asp Ala Leu Glu Val Leu Arg Ile Leu Leu Tyr Ser Tyr Lys 
    930                 935                 940                 


Val Ser Phe Lys Glu Gly Ser Lys Ala Lys Asp Asn Asn Asp Asn Ile 
945                 950                 955                 960 


Asp Glu Asn Lys Tyr Leu Lys Ile Leu Glu Gly Phe Ile Glu Phe Thr 
                965                 970                 975     


Ser Lys Asp Asn Glu Glu Arg Glu Ile Glu Lys Ser Glu Leu Ile Lys 
            980                 985                 990         


Phe Asn Glu Val Leu Asp Gly Arg  Asp Gln Leu Tyr Ile  Gln Lys Asp 
        995                 1000                 1005             


Asn Lys  Thr Leu Val Lys Phe  Gly Gln Ile Ile Glu  Ala Tyr Lys 
    1010                 1015                 1020             


Glu Asn  Leu Leu Gly Arg Tyr  Lys Glu Tyr Tyr Lys  Asn Asn Lys 
    1025                 1030                 1035             


Ile Ala  Leu Asp Glu Val Lys  Arg Phe Asn Glu Leu  Glu Lys Asp 
    1040                 1045                 1050             


Ile Gly  Asp Ile Thr Lys Glu  Ile Asp Ala Lys Lys  Glu Lys Met 
    1055                 1060                 1065             


Lys Lys  Asn Ser Lys Asn Asn  Asn Lys Thr Lys Lys  Glu Tyr Arg 
    1070                 1075                 1080             


Glu Lys  Tyr Lys Lys Lys Leu  Glu Tyr Ile Trp Leu  Lys Asn Arg 
    1085                 1090                 1095             


Ile Leu  Phe Asn Asp Val Ser  Lys Met Asn Arg Leu  Ile Ile Asp 
    1100                 1105                 1110             


Val Tyr  Ser Arg Leu Asn Gly  Leu Ile Ala Val Leu  Glu Lys Asp 
    1115                 1120                 1125             


Phe Val  His Leu Leu Lys Glu  Arg Asn Pro Thr Leu  Arg Ile Thr 
    1130                 1135                 1140             


Lys Lys  Thr Asp Ile Ile Asp  Ser Phe Ile Asn Asn  Asn Ser Leu 
    1145                 1150                 1155             


Asn Ser  Ile Tyr His Tyr Ser  Asn Lys Asp Tyr Asn  Pro Asn Gly 
    1160                 1165                 1170             


Arg Ser  Pro Asn Glu Gln Asp  Lys Glu Ile Arg Asn  Arg Phe Ala 
    1175                 1180                 1185             


His Phe  His Tyr Leu Arg Asp  Asp Lys Gly Ser Ser  Val Asp Phe 
    1190                 1195                 1200             


Ile Thr  Gln Leu Asn Leu Leu  Arg Arg Leu Leu Arg  Ile Asp Arg 
    1205                 1210                 1215             


Lys Leu  Lys Asn Ala Val Thr  Lys Thr Val Ile Lys  Thr Phe Asp 
    1220                 1225                 1230             


Lys His  Gly Phe Asn Leu Val  Phe Glu Phe Glu Asn  His Glu Ile 
    1235                 1240                 1245             


Lys Ser  Tyr Ser Leu Lys Arg  Asn Lys Leu Thr Asp  Lys Tyr Leu 
    1250                 1255                 1260             


Asp Asn  Tyr Ile Asn Val Tyr  Pro Asn Asn Asp Phe  Met Leu Glu 
    1265                 1270                 1275             


Met Ile  Glu Lys Ile Ile Phe  Lys Asp Cys Thr Lys  Lys 
    1280                 1285                 1290     


<210>  429
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  429

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Asp Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn Tyr Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Gly Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Gly Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Lys Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Arg Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Asp Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  430
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  430

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Pro Gly Thr Asp Thr 
            20                  25                  30          


Ile Gly Leu Lys Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Asp Lys Pro Lys Lys 
    50                  55                  60                  


Trp Lys Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Glu Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Ser Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Met Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Tyr Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ser Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Gln Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Phe 
            660                 665                 670         


Ile Arg Lys Asn Phe Pro Glu Asp Ile Ser Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val Tyr Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Asp Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Asp Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asn  Ser Glu Lys Lys Glu  Ala Tyr Gln Lys Ile  Glu Val Asn 
    1100                 1105                 1110             


Gly Asp  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Val  Tyr Ala Pro Asp Glu  Lys Gly Asp 
    1130                 1135                 1140             


Ile Leu  Lys Glu Gln Cys Thr  Lys Gly Gly Ala Gly  Gly Lys Ile 
    1145                 1150                 1155             


Ser Ala  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Lys Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Lys Gln 
    1250                 1255                 1260             


Thr Thr  Ser Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Ser Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Lys  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Val Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Gly Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Pro Asn 
    1370                 1375                 1380         


<210>  431
<211>  1380
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  431

Met Lys Leu Ser Lys Glu Lys Gln Ile Arg Ser Ala Val Ala Asn Lys 
1               5                   10                  15      


Glu Lys Asn Thr Glu Gly Val Leu Tyr Arg Phe Pro Gly Ala Asp Ile 
            20                  25                  30          


Gly Gly Val Gln Ala Gln Met Leu Val Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Leu Gly Asn Lys Pro Lys Glu 
    50                  55                  60                  


Trp Met Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Lys Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Ala Ile Asn Asp Ile Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Lys Glu Ala Asp Lys Lys Ile Arg Asn Met Ser Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Asn Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Gly Asn Gln Glu Phe Asp Ser Ile Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp Arg 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Asp Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Ser Ile Gln Asp Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Ile Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Glu Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Ala Glu Lys Asp Gly Leu Asn Glu Phe Met Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Glu Glu Lys Arg Ala Glu Val Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Ser His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Val Asn Lys Glu Lys Phe Tyr Val Trp 
305                 310                 315                 320 


Lys Lys His Glu Cys Gly Lys Lys Glu Asn Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Val Glu Ala Glu Ala Glu Ser Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Ile Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Thr Gly Thr Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Lys Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asn Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Gln Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Leu 
            660                 665                 670         


Phe Arg Thr Val Phe Pro Glu Tyr Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Asn Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Arg Thr Leu Arg Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Lys 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Glu Asn Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Cys Ala Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu 
        915                 920                 925             


Leu Ser Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Lys Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Lys Phe Ser Glu Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Thr Asn Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Gly  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Glu Lys Pro Glu  Glu Tyr Glu Lys Ile  Glu Ala Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Ile  Tyr Ala Pro Glu Lys  Asn Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Gln Gly Arg Val Gly  Ala Lys Val 
    1145                 1150                 1155             


Thr Ser  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Glu Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Met Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Val Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Val Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Asp  Asp Glu Asp Ala Asp  Thr Lys Lys Pro Val  Ile Val Thr 
    1310                 1315                 1320             


Asn Val  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Glu  Asp Glu Asp 
    1325                 1330                 1335             


Lys Gln  Lys Gly Lys Glu Asn  Arg Gly Lys Lys Asn  Thr Glu Thr 
    1340                 1345                 1350             


Arg Ser  Asp Ala Glu Lys Asn  Asn Asn Asp Arg Leu  Ser Tyr Asn 
    1355                 1360                 1365             


Pro Phe  Ala Asn Phe Asp Phe  Lys Leu Pro Asn Lys  
    1370                 1375                 1380 


<210>  432
<211>  1228
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  432

Met Asn Asn Lys Ser Phe Asn Tyr Lys Ala Met Gln Phe Ile Pro Asp 
1               5                   10                  15      


Ile Gln Asn Pro Lys Thr Asn Asp Ala Val Asn Tyr Arg Thr Asp Arg 
            20                  25                  30          


Asp Asn Val Tyr Asn Lys Asn Lys Tyr Tyr Asp Lys Gln Thr Lys Ser 
        35                  40                  45              


Lys Ser Lys Lys Phe Ile Tyr Glu Lys Ile Ala Ile Pro Gln Asn Glu 
    50                  55                  60                  


Gln Asn Ile Val Ile Ser Ala Leu Val Asn Cys Ser Leu Arg Lys Ser 
65                  70                  75                  80  


Leu Arg Lys Asp Val Ser Tyr Lys Thr Lys Ser Gly Glu Ile Lys Thr 
                85                  90                  95      


Tyr Asn Leu Pro Glu Leu Val Lys Lys Ser Met Lys Phe Tyr Cys Leu 
            100                 105                 110         


Glu Gly Gln Arg Glu Pro Asp Glu Lys Glu Lys Tyr Glu Met Tyr Ile 
        115                 120                 125             


Leu Phe Ser Tyr Met Lys Glu Asp Lys Arg Thr Lys Asn Thr Asp Leu 
    130                 135                 140                 


Leu Val Lys Ser Ile Ser Asn Gln Asn Thr Lys Val Lys Val Glu Asp 
145                 150                 155                 160 


Ile Asp Gly Asn Lys Leu Leu Lys Leu Ser Ile Ala Asp Thr Lys Lys 
                165                 170                 175     


Lys Pro Leu Trp Glu Tyr Leu Ile Lys Tyr Ala Asp Ser Ser Arg Gln 
            180                 185                 190         


Arg Glu Leu Met Tyr Asp Ile Arg Lys Lys Ile Ile Leu Tyr Val Ala 
        195                 200                 205             


Gly Ile Glu Glu Tyr Glu Asn Ile Lys Glu Asp Ser Gly Leu Ser Lys 
    210                 215                 220                 


Val Ser Trp Ser Lys Tyr Asn Ile Ser Asp Asn Lys Met Phe Phe Asp 
225                 230                 235                 240 


Ile Asn Ser Cys Thr Asp Lys Arg Lys Gln Asn Leu Glu Ile Lys Ile 
                245                 250                 255     


Arg Glu Ala Asn Ile Glu His Tyr Arg Asn Ala Ser Ser Lys Leu Cys 
            260                 265                 270         


Asp Asp Glu Ser Ile Phe Trp Phe Gln His Phe Glu Gly Val Ile Glu 
        275                 280                 285             


Thr Leu Phe Ser Lys Lys Ser Lys Ile Ser Glu Glu Arg Leu Gly Cys 
    290                 295                 300                 


Ala Tyr Ile Cys Asp Tyr Leu Trp Lys Asp Phe Leu Ser Tyr Leu Ala 
305                 310                 315                 320 


Ala Lys Tyr Ile Asp Leu Gly Lys Gly Val Tyr His Phe Thr Met Lys 
                325                 330                 335     


Asp Lys Leu Asp Met Leu Asn Lys Asn Glu Ala Val Thr Asp Leu Arg 
            340                 345                 350         


Phe Gly Ile Val Ser Glu Lys Tyr Glu Lys Gly Ile Thr Ser Phe Asp 
        355                 360                 365             


Tyr Glu Arg Ile Lys Ala Glu Glu Glu Leu Asp Arg Asn Ile Ala Ala 
    370                 375                 380                 


Tyr Val Thr Phe Ala Ala Asp Ile Phe Ala Lys Ser Val Ile Lys Ser 
385                 390                 395                 400 


Asp Tyr Arg Thr Lys Lys Asp Asn Asn Ser Asp Val Leu Gln Tyr Ser 
                405                 410                 415     


Asp Lys Glu Phe Arg Asn Ser Glu Val Ile Arg Asp Asn Ala Glu Lys 
            420                 425                 430         


Asn Ile Leu Gln Tyr Trp Gly Gly Tyr Ser Arg Trp Gly Thr Glu Asn 
        435                 440                 445             


Ser Lys Leu Pro Glu Asn Asn Lys Val Ser Asp Phe Gly Lys Leu Asp 
    450                 455                 460                 


Val Ser Asp Leu Cys Ile Asp Ile Lys Lys His Leu Ala Gly Ile Arg 
465                 470                 475                 480 


Asn Ser Ser Val His Tyr Thr Thr Lys Ile Lys Asn Glu Ser Ala Ala 
                485                 490                 495     


Asp Gly Ser Asn Val Lys Ile Leu Phe Glu Lys Asp Leu Ala Asp Ile 
            500                 505                 510         


Asn Ile Ile Tyr Ala Asp Lys Tyr Tyr Ser Asn Asn Val Trp Met Phe 
        515                 520                 525             


Tyr Ser Leu Glu Asp Ile Asn Lys Leu Ile Ala Phe Leu Tyr Lys Glu 
    530                 535                 540                 


Lys Arg Val Ile Arg Gln Val Gln Ile Pro Ser Phe Ser His Ile Leu 
545                 550                 555                 560 


Lys Arg Lys Ala Met Gln Asp Val Ile Asn Glu Ile Phe Lys Asp Asp 
                565                 570                 575     


Phe Asp Glu Asn Ile Val Asn Pro Glu Leu Lys Glu Lys Tyr Arg Asn 
            580                 585                 590         


Ser Leu Tyr Phe Met Leu Lys Glu Ile Tyr Tyr Asn Ala Phe Ile Ile 
        595                 600                 605             


Gln Pro Glu Leu Lys Glu Lys Phe Lys Asp Lys Ile Lys Thr Met Lys 
    610                 615                 620                 


Ser Glu Leu Tyr Asn Lys Leu Lys Thr Ile Asp Lys Lys Glu Tyr Lys 
625                 630                 635                 640 


Ala Leu Tyr Cys Met Leu Ser Asn Glu Glu Ser Ala Leu Lys Asn Phe 
                645                 650                 655     


Ala Asp Arg Ile Tyr Ser Val Asp Gly Asp Asn Val Ser Phe Ala Asp 
            660                 665                 670         


Ile Cys Lys Ile Leu Met Thr Asp Tyr Asn Met Gln Asn Gln Glu Lys 
        675                 680                 685             


Lys Asn Ile Glu Ser Met Glu Gln Lys Lys Lys Asn Lys Gly Lys Asp 
    690                 695                 700                 


Glu Asn Tyr Lys His Phe Pro Leu Leu Leu His Lys Val Leu Lys Glu 
705                 710                 715                 720 


Leu Phe Ile Glu Tyr Leu Lys Gln Thr His Glu Leu Glu Phe Leu Arg 
                725                 730                 735     


Asn Asn Ile Cys Ile Lys Ser Asp Val Thr Met Glu Ser Phe Glu Ser 
            740                 745                 750         


Gln Ile Lys Gly Val Glu Ile Tyr Lys Asp Leu Lys Glu Lys Ile Asp 
        755                 760                 765             


Lys Asn Asn Ser Leu Leu Asp Trp Tyr Val Ile Ala His Phe Leu Met 
    770                 775                 780                 


Pro Lys Gln Leu Asn His Leu Ile Gly Asn Ile Lys Asn Tyr Ile Gln 
785                 790                 795                 800 


Phe Ala Thr Asn Ile Asp Lys Arg Ala Glu Ser Val Lys Asn Leu Thr 
                805                 810                 815     


Glu Ser Gly Met Val Lys Arg Ile Gln Tyr Tyr Asp Asp Ile Val Arg 
            820                 825                 830         


Thr Leu Glu Phe Ser Ala Gln Tyr Ile Gly Lys Ile Ser Asn Asn Ile 
        835                 840                 845             


Asn Asp Tyr Phe Asn Ser Glu Asp Glu Tyr Val Ser Phe Leu Ser Lys 
    850                 855                 860                 


Tyr Val Gly Phe Ile Asn Asp Lys Ser Glu Asp Val Leu Thr Glu Leu 
865                 870                 875                 880 


Lys Asp Phe Cys Arg Glu Lys Ile Asn Asn Gly Ser Gln Ile Ile Gly 
                885                 890                 895     


Ile Tyr Tyr Gly Gly Asp Asn Val Ile Ile Asn Arg Asn Val Ile Tyr 
            900                 905                 910         


Ala Gln Met Tyr Ser Asn Ala Glu Val Phe Ser Asn Ile Tyr Lys Lys 
        915                 920                 925             


Val Thr Lys Asn Asp Ile Ile Asn Tyr Tyr Glu Lys Gln Asn Asp Leu 
    930                 935                 940                 


Lys Asp Val Phe Lys Ser Gly Val Cys Gln Asn Asp Asp Glu Gln Arg 
945                 950                 955                 960 


Ser Leu Cys Glu Phe Gln Gln Leu Lys Asn Arg Ile Glu Leu Thr Glu 
                965                 970                 975     


Leu Ser Thr Tyr Ala Asp Met Val Asn Asp Phe Met Ala Gln Phe Val 
            980                 985                 990         


Glu Trp Ala Tyr Leu Arg Glu Arg  Asp Leu Met Tyr Phe  Gln Leu Gly 
        995                 1000                 1005             


Ile His  Tyr Ile Arg Leu Phe  Tyr Ser Asp Asn Val  Leu Asp Glu 
    1010                 1015                 1020             


Lys Tyr  His Lys Leu Arg Asp  Asn Val Ile Asp Ile  Glu Glu Gly 
    1025                 1030                 1035             


Ala Leu  Leu Tyr Gln Ile Val  Ala Met Tyr Asp Tyr  Glu Leu Arg 
    1040                 1045                 1050             


Ile Phe  Glu Thr Asp Asn Ser  Gly Asn Ala Lys Arg  Ile Gly Gln 
    1055                 1060                 1065             


Gly Gly  Pro Gly Lys Ser Ile  Pro Val Phe Leu Lys  Lys Tyr Cys 
    1070                 1075                 1080             


Asn Gly  Thr Asp Val Tyr Glu  Cys Gly Leu Glu Leu  Phe Glu Asp 
    1085                 1090                 1095             


Ile Asn  Gln His Glu His Ile  Ile Arg Phe Arg Asn  Asp Ile Ala 
    1100                 1105                 1110             


His Met  Arg Tyr Met Ser Asn  Gln Ala Met Asn Ile  Met Ser Ile 
    1115                 1120                 1125             


Val Ser  Asn Ile Tyr Lys Ser  Phe Phe Val Tyr Asp  Thr Lys Leu 
    1130                 1135                 1140             


Lys Lys  Ser Ile Ser Leu Val  Phe Lys Asn Ile Leu  Met Arg Tyr 
    1145                 1150                 1155             


Gly Val  Ile Ala Asp Leu Val  Ile Ser Tyr Asn Asn  Lys Asn Gln 
    1160                 1165                 1170             


Ser Ile  Lys Asp Asp Met Asp  Ile Asn Ile Ile Asn  Ile Lys Asn 
    1175                 1180                 1185             


Leu Lys  Ser Asp Lys Tyr Val  Tyr Lys Ile Val Asn  Glu Asp Ile 
    1190                 1195                 1200             


Val Lys  Gln Val Glu Ile Glu  Ile Arg Asn Gln Val  Phe Leu Glu 
    1205                 1210                 1215             


Gln Leu  His Asn Leu Leu Tyr  Phe Ser Arg 
    1220                 1225             


<210>  433
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  433

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Asp Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn Tyr Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Gly Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Gly Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Lys Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Arg Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Asp Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  434
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  434

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Pro Gly Thr Asp Thr 
            20                  25                  30          


Ile Gly Leu Lys Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Asp Lys Pro Lys Lys 
    50                  55                  60                  


Trp Lys Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Glu Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Ser Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Met Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Tyr Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ser Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Gln Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Phe 
            660                 665                 670         


Ile Arg Lys Asn Phe Pro Glu Asp Ile Ser Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val Tyr Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Asp Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Asp Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asn  Ser Glu Lys Lys Glu  Ala Tyr Gln Lys Ile  Glu Val Asn 
    1100                 1105                 1110             


Gly Asp  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Val  Tyr Ala Pro Asp Glu  Lys Gly Asp 
    1130                 1135                 1140             


Ile Leu  Lys Glu Gln Cys Thr  Lys Gly Gly Ala Gly  Gly Lys Ile 
    1145                 1150                 1155             


Ser Ala  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Lys Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Lys Gln 
    1250                 1255                 1260             


Thr Thr  Ser Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Ser Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Lys  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Val Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Gly Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Pro Asn 
    1370                 1375                 1380         


<210>  435
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  435

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Leu Tyr Gln Ile Val  Ser Ala Phe Asn Phe  Gly Ser Lys 
    1205                 1210                 1215             


Leu Leu  Tyr Ile Ser Glu Asp  Gly Arg Trp Lys Met  Ala Gly Gly 
    1220                 1225                 1230             


Ala Phe  Pro Gly Lys Tyr Gly  Arg Phe Glu Asn Asp  Tyr Asn His 
    1235                 1240                 1245             


Arg Thr  Ser Leu Ser Lys Val  Ile Arg Leu Phe Glu  Asn Glu Ser 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ile Ile Tyr  Trp Arg Asp Tyr Val  Asp His Met 
    1265                 1270                 1275             


Lys Tyr  Tyr Val Asn Gln Asn  Gln Ser Ile Met Glu  Ile Tyr Ser 
    1280                 1285                 1290             


Ala Phe  Tyr Ser Lys Val Leu  Gly Tyr Ser Ala Lys  Leu Arg Lys 
    1295                 1300                 1305             


Ser Val  Val Phe Asn Leu Gln  Ala Ala Leu Glu Lys  His His Ile 
    1310                 1315                 1320             


Asn Pro  Glu Cys Ile Trp Met  Thr Ser Asp Gly Lys  Cys Ala Asp 
    1325                 1330                 1335             


Ile Lys  Leu Met Lys Asn Leu  Glu Ser Gln Lys Phe  Thr Tyr Lys 
    1340                 1345                 1350             


Leu Ala  Lys Arg Glu Gly Glu  Lys Thr Glu Arg Lys  Ile Cys Met 
    1355                 1360                 1365             


Asn Ala  Leu Asn Glu Asn Phe  Leu Lys Thr Ile Arg  Thr Ser Leu 
    1370                 1375                 1380             


Glu Tyr  Lys Lys 
    1385         


<210>  436
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  436

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Asp Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn Tyr Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Gly Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Gly Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Lys Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Arg Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Asp Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  437
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  437

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Asp Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn Tyr Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Gly Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Gly Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Lys Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Arg Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Asp Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  438
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  438

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Pro Gly Thr Asp Thr 
            20                  25                  30          


Ile Gly Leu Lys Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Asp Lys Pro Lys Lys 
    50                  55                  60                  


Trp Lys Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Glu Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Ser Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Met Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Tyr Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ser Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Gln Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Phe 
            660                 665                 670         


Ile Arg Lys Asn Phe Pro Glu Asp Ile Ser Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val Tyr Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Asp Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Asp Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asn  Ser Glu Lys Lys Glu  Ala Tyr Gln Lys Ile  Glu Val Asn 
    1100                 1105                 1110             


Gly Asp  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Val  Tyr Ala Pro Asp Glu  Lys Gly Asp 
    1130                 1135                 1140             


Ile Leu  Lys Glu Gln Cys Thr  Lys Gly Gly Ala Gly  Gly Lys Ile 
    1145                 1150                 1155             


Ser Ala  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Lys Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Lys Gln 
    1250                 1255                 1260             


Thr Thr  Ser Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Ser Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Lys  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Val Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Gly Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Pro Asn 
    1370                 1375                 1380         


<210>  439
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  439

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Pro Gly Thr Asp Thr 
            20                  25                  30          


Ile Gly Leu Lys Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Asp Lys Pro Lys Lys 
    50                  55                  60                  


Trp Lys Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Glu Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Ser Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Met Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Tyr Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ser Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Gln Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Phe 
            660                 665                 670         


Ile Arg Lys Asn Phe Pro Glu Asp Ile Ser Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val Tyr Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Asp Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Asp Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asn  Ser Glu Lys Lys Glu  Ala Tyr Gln Lys Ile  Glu Val Asn 
    1100                 1105                 1110             


Gly Asp  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Val  Tyr Ala Pro Asp Glu  Lys Gly Asp 
    1130                 1135                 1140             


Ile Leu  Lys Glu Gln Cys Thr  Lys Gly Gly Ala Gly  Gly Lys Ile 
    1145                 1150                 1155             


Ser Ala  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Lys Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Lys Gln 
    1250                 1255                 1260             


Thr Thr  Ser Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Ser Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Lys  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Val Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Gly Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Pro Asn 
    1370                 1375                 1380         


<210>  440
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  440

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Gly Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asp 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  441
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  441

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Asp Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn Tyr Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Gly Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Gly Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Lys Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Arg Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Asp Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  442
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  442

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Leu Tyr Gln Ile Val  Ser Ala Phe Asn Phe  Gly Ser Lys 
    1205                 1210                 1215             


Leu Leu  Tyr Ile Ser Glu Asp  Gly Arg Trp Lys Met  Ala Gly Gly 
    1220                 1225                 1230             


Ala Phe  Pro Gly Lys Tyr Gly  Arg Phe Glu Asn Asp  Tyr Asn His 
    1235                 1240                 1245             


Arg Thr  Ser Leu Ser Lys Val  Ile Arg Leu Phe Glu  Asn Glu Ser 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ile Ile Tyr  Trp Arg Asp Tyr Val  Asp His Met 
    1265                 1270                 1275             


Lys Tyr  Tyr Val Asn Gln Asn  Gln Ser Ile Met Glu  Ile Tyr Ser 
    1280                 1285                 1290             


Ala Phe  Tyr Ser Lys Val Leu  Gly Tyr Ser Ala Lys  Leu Arg Lys 
    1295                 1300                 1305             


Ser Val  Val Phe Asn Leu Gln  Ala Ala Leu Glu Lys  His His Ile 
    1310                 1315                 1320             


Asn Pro  Glu Cys Ile Trp Met  Thr Ser Asp Gly Lys  Cys Ala Asp 
    1325                 1330                 1335             


Ile Lys  Leu Met Lys Asn Leu  Glu Ser Gln Lys Phe  Thr Tyr Lys 
    1340                 1345                 1350             


Leu Ala  Lys Arg Glu Gly Glu  Lys Thr Glu Arg Lys  Ile Cys Met 
    1355                 1360                 1365             


Asn Ala  Leu Asn Glu Asn Phe  Leu Lys Thr Ile Arg  Thr Ser Leu 
    1370                 1375                 1380             


Glu Tyr  Lys Lys 
    1385         


<210>  443
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  443

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Leu Tyr Gln Ile Val  Ser Ala Phe Asn Phe  Gly Ser Lys 
    1205                 1210                 1215             


Leu Leu  Tyr Ile Ser Glu Asp  Gly Arg Trp Lys Met  Ala Gly Gly 
    1220                 1225                 1230             


Ala Phe  Pro Gly Lys Tyr Gly  Arg Phe Glu Asn Asp  Tyr Asn His 
    1235                 1240                 1245             


Arg Thr  Ser Leu Ser Lys Val  Ile Arg Leu Phe Glu  Asn Glu Ser 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ile Ile Tyr  Trp Arg Asp Tyr Val  Asp His Met 
    1265                 1270                 1275             


Lys Tyr  Tyr Val Asn Gln Asn  Gln Ser Ile Met Glu  Ile Tyr Ser 
    1280                 1285                 1290             


Ala Phe  Tyr Ser Lys Val Leu  Gly Tyr Ser Ala Lys  Leu Arg Lys 
    1295                 1300                 1305             


Ser Val  Val Phe Asn Leu Gln  Ala Ala Leu Glu Lys  His His Ile 
    1310                 1315                 1320             


Asn Pro  Glu Cys Ile Trp Met  Thr Ser Asp Gly Lys  Cys Ala Asp 
    1325                 1330                 1335             


Ile Lys  Leu Met Lys Asn Leu  Glu Ser Gln Lys Phe  Thr Tyr Lys 
    1340                 1345                 1350             


Leu Ala  Lys Arg Glu Gly Glu  Lys Thr Glu Arg Lys  Ile Cys Met 
    1355                 1360                 1365             


Asn Ala  Leu Asn Glu Asn Phe  Leu Lys Thr Ile Arg  Thr Ser Leu 
    1370                 1375                 1380             


Glu Tyr  Lys Lys 
    1385         


<210>  444
<211>  1357
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  444

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Pro Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Lys Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Asp Ile Gln Lys Ile Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Lys Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Cys Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Thr Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Phe 
                325                 330                 335     


Asn Gly Leu Glu Glu Leu Glu Asn Leu Ser Gln Gln Lys Lys Glu Lys 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Arg Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Cys Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Lys 
                405                 410                 415     


Arg Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Ala Leu Glu Gly Glu Ser 
    450                 455                 460                 


Val Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Glu Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Ala Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Leu Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Arg Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Lys Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Lys Gly Asp Lys Glu Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Glu Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Ser Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Lys Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Ala Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Val Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Glu Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Met Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Val Leu Val Pro Ala  Arg Ser Glu 
    1325                 1330                 1335             


Val Phe  Leu Lys Gln Phe Arg  Lys Ile Leu Glu Tyr  Arg Ile Gln 
    1340                 1345                 1350             


Asp Lys  Thr Gln 
    1355         


<210>  445
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  445

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  446
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  446

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Leu Tyr Gln Ile Val  Ser Ala Phe Asn Phe  Gly Ser Lys 
    1205                 1210                 1215             


Leu Leu  Tyr Ile Ser Glu Asp  Gly Arg Trp Lys Met  Ala Gly Gly 
    1220                 1225                 1230             


Ala Phe  Pro Gly Lys Tyr Gly  Arg Phe Glu Asn Asp  Tyr Asn His 
    1235                 1240                 1245             


Arg Thr  Ser Leu Ser Lys Val  Ile Arg Leu Phe Glu  Asn Glu Ser 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ile Ile Tyr  Trp Arg Asp Tyr Val  Asp His Met 
    1265                 1270                 1275             


Lys Tyr  Tyr Val Asn Gln Asn  Gln Ser Ile Met Glu  Ile Tyr Ser 
    1280                 1285                 1290             


Ala Phe  Tyr Ser Lys Val Leu  Gly Tyr Ser Ala Lys  Leu Arg Lys 
    1295                 1300                 1305             


Ser Val  Val Phe Asn Leu Gln  Ala Ala Leu Glu Lys  His His Ile 
    1310                 1315                 1320             


Asn Pro  Glu Cys Ile Trp Met  Thr Ser Asp Gly Lys  Cys Ala Asp 
    1325                 1330                 1335             


Ile Lys  Leu Met Lys Asn Leu  Glu Ser Gln Lys Phe  Thr Tyr Lys 
    1340                 1345                 1350             


Leu Ala  Lys Arg Glu Gly Glu  Lys Thr Glu Arg Lys  Ile Cys Met 
    1355                 1360                 1365             


Asn Ala  Leu Asn Glu Asn Phe  Leu Lys Thr Ile Arg  Thr Ser Leu 
    1370                 1375                 1380             


Glu Tyr  Lys Lys 
    1385         


<210>  447
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  447

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Leu Tyr Gln Ile Val  Ser Ala Phe Asn Phe  Gly Ser Lys 
    1205                 1210                 1215             


Leu Leu  Tyr Ile Ser Glu Asp  Gly Arg Trp Lys Met  Ala Gly Gly 
    1220                 1225                 1230             


Ala Phe  Pro Gly Lys Tyr Gly  Arg Phe Glu Asn Asp  Tyr Asn His 
    1235                 1240                 1245             


Arg Thr  Ser Leu Ser Lys Val  Ile Arg Leu Phe Glu  Asn Glu Ser 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ile Ile Tyr  Trp Arg Asp Tyr Val  Asp His Met 
    1265                 1270                 1275             


Lys Tyr  Tyr Val Asn Gln Asn  Gln Ser Ile Met Glu  Ile Tyr Ser 
    1280                 1285                 1290             


Ala Phe  Tyr Ser Lys Val Leu  Gly Tyr Ser Ala Lys  Leu Arg Lys 
    1295                 1300                 1305             


Ser Val  Val Phe Asn Leu Gln  Ala Ala Leu Glu Lys  His His Ile 
    1310                 1315                 1320             


Asn Pro  Glu Cys Ile Trp Met  Thr Ser Asp Gly Lys  Cys Ala Asp 
    1325                 1330                 1335             


Ile Lys  Leu Met Lys Asn Leu  Glu Ser Gln Lys Phe  Thr Tyr Lys 
    1340                 1345                 1350             


Leu Ala  Lys Arg Glu Gly Glu  Lys Thr Glu Arg Lys  Ile Cys Met 
    1355                 1360                 1365             


Asn Ala  Leu Asn Glu Asn Phe  Leu Lys Thr Ile Arg  Thr Ser Leu 
    1370                 1375                 1380             


Glu Tyr  Lys Lys 
    1385         


<210>  448
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  448

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Leu Tyr Gln Ile Val  Ser Ala Phe Asn Phe  Gly Ser Lys 
    1205                 1210                 1215             


Leu Leu  Tyr Ile Ser Glu Asp  Gly Arg Trp Lys Met  Ala Gly Gly 
    1220                 1225                 1230             


Ala Phe  Pro Gly Lys Tyr Gly  Arg Phe Glu Asn Asp  Tyr Asn His 
    1235                 1240                 1245             


Arg Thr  Ser Leu Ser Lys Val  Ile Arg Leu Phe Glu  Asn Glu Ser 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ile Ile Tyr  Trp Arg Asp Tyr Val  Asp His Met 
    1265                 1270                 1275             


Lys Tyr  Tyr Val Asn Gln Asn  Gln Ser Ile Met Glu  Ile Tyr Ser 
    1280                 1285                 1290             


Ala Phe  Tyr Ser Lys Val Leu  Gly Tyr Ser Ala Lys  Leu Arg Lys 
    1295                 1300                 1305             


Ser Val  Val Phe Asn Leu Gln  Ala Ala Leu Glu Lys  His His Ile 
    1310                 1315                 1320             


Asn Pro  Glu Cys Ile Trp Met  Thr Ser Asp Gly Lys  Cys Ala Asp 
    1325                 1330                 1335             


Ile Lys  Leu Met Lys Asn Leu  Glu Ser Gln Lys Phe  Thr Tyr Lys 
    1340                 1345                 1350             


Leu Ala  Lys Arg Glu Gly Glu  Lys Thr Glu Arg Lys  Ile Cys Met 
    1355                 1360                 1365             


Asn Ala  Leu Asn Glu Asn Phe  Leu Lys Thr Ile Arg  Thr Ser Leu 
    1370                 1375                 1380             


Glu Tyr  Lys Lys 
    1385         


<210>  449
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  449

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Leu Tyr Gln Ile Val  Ser Ala Phe Asn Phe  Gly Ser Lys 
    1205                 1210                 1215             


Leu Leu  Tyr Ile Ser Glu Asp  Gly Arg Trp Lys Met  Ala Gly Gly 
    1220                 1225                 1230             


Ala Phe  Pro Gly Lys Tyr Gly  Arg Phe Glu Asn Asp  Tyr Asn His 
    1235                 1240                 1245             


Arg Thr  Ser Leu Ser Lys Val  Ile Arg Leu Phe Glu  Asn Glu Ser 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ile Ile Tyr  Trp Arg Asp Tyr Val  Asp His Met 
    1265                 1270                 1275             


Lys Tyr  Tyr Val Asn Gln Asn  Gln Ser Ile Met Glu  Ile Tyr Ser 
    1280                 1285                 1290             


Ala Phe  Tyr Ser Lys Val Leu  Gly Tyr Ser Ala Lys  Leu Arg Lys 
    1295                 1300                 1305             


Ser Val  Val Phe Asn Leu Gln  Ala Ala Leu Glu Lys  His His Ile 
    1310                 1315                 1320             


Asn Pro  Glu Cys Ile Trp Met  Thr Ser Asp Gly Lys  Cys Ala Asp 
    1325                 1330                 1335             


Ile Lys  Leu Met Lys Asn Leu  Glu Ser Gln Lys Phe  Thr Tyr Lys 
    1340                 1345                 1350             


Leu Ala  Lys Arg Glu Gly Glu  Lys Thr Glu Arg Lys  Ile Cys Met 
    1355                 1360                 1365             


Asn Ala  Leu Asn Glu Asn Phe  Leu Lys Thr Ile Arg  Thr Ser Leu 
    1370                 1375                 1380             


Glu Tyr  Lys Lys 
    1385         


<210>  450
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  450

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Asp Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn Tyr Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Gly Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Gly Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Lys Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Arg Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Asp Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  451
<211>  1411
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  451

Met Lys Ile Ser Lys Val Asn His Thr His Ala Ala Val Val Lys Lys 
1               5                   10                  15      


Asn Asp Gly Lys Ser Gly Gly Ile Leu Tyr Val Asp Pro Ser Gln Ser 
            20                  25                  30          


Gly Ala Leu Asp Leu Gly Lys Arg Phe Asp Ser Leu Asn Arg Lys Ala 
        35                  40                  45              


Gln Arg Leu Tyr Asn Phe Phe Asn Pro Val Gln Ala Gly Thr Glu Pro 
    50                  55                  60                  


Lys Glu Val Lys Lys Arg Glu Asn Glu Ser Asp Asp Ser Tyr Leu Ala 
65                  70                  75                  80  


Arg Lys Glu Asn Asn Asn Ile Ser Lys Ala Asn Tyr Glu Arg Arg Leu 
                85                  90                  95      


Lys Trp Glu Arg Lys Ile Gly Pro Ile Asn Lys Thr Ile Arg Ser Val 
            100                 105                 110         


Met Phe Tyr Asp Asp Asp Lys Lys Asn Arg His Val Cys Asp Ser Arg 
        115                 120                 125             


Arg Val Leu Glu Asn Leu Gly Gln Gln Gln Gly Leu Ala Glu Gln Asp 
    130                 135                 140                 


Ile Asn Glu Val Val Thr Leu Phe Leu Arg Asn Ser Leu Ser Lys Cys 
145                 150                 155                 160 


Ala Glu Asn Val Lys Thr Leu Leu Arg Cys Met Gly Lys Ser Gly Ile 
                165                 170                 175     


Ser Glu Gln Glu Lys Val Glu Ile Asn Glu Leu Ile Asp Phe Val Lys 
            180                 185                 190         


Lys Asp Phe Glu Lys Thr Glu Ala Lys Asn Arg Ile Ile Arg Ser Ile 
        195                 200                 205             


Lys Asn Gln Asn Met Thr Val Gln Pro Gln Lys Gly Val Gly Asp Pro 
    210                 215                 220                 


Ile Leu Arg Leu Ser Asp Asn Thr Asn Ser Lys Ser Asn Ser Ile Lys 
225                 230                 235                 240 


Lys Asp Glu Lys Glu Gly Leu Asn Ser Phe Ile Ser Asp Tyr Ala Asp 
                245                 250                 255     


Leu Asn Pro Asp Ser Arg Met Glu Met Leu Arg Lys Leu Arg Arg Leu 
            260                 265                 270         


Val Asp Leu Tyr Phe Gly Ala Pro Asn Glu Tyr Gln Lys Gly Asp Ile 
        275                 280                 285             


Leu Asn Leu Pro Gln Arg Val Asn Cys Asp Pro Asp Tyr Asp Val Trp 
    290                 295                 300                 


Lys Ala His Glu Ala Ala Lys Gln Glu Asn Glu Pro Phe Ala Asp Ile 
305                 310                 315                 320 


Pro Lys Gly Leu Leu Lys Ala Tyr Asn Glu Lys Lys Lys Leu Asp Ser 
                325                 330                 335     


Val Glu Gln Lys Arg Asp Gln Lys Ala Ile Met Asp Gly Ile Arg Ala 
            340                 345                 350         


Arg Asn Ile Ile Cys Tyr Arg Tyr Ser Leu Ala Ile Val Glu Asn Asp 
        355                 360                 365             


Asp Arg Asn Leu Phe Phe Ser Asp Ile Arg Ile Asn Lys Phe Trp Ile 
    370                 375                 380                 


His His Ile Gln Ser Ala Val Glu Arg Ile Leu Lys Asn Ile Ser Val 
385                 390                 395                 400 


Glu Lys Leu Tyr Arg Asn Asp Val Gly Tyr Leu Ser Glu Lys Val Trp 
                405                 410                 415     


Lys Asp Leu Leu Asn Tyr Leu Cys Val Lys Tyr Ile Ala Ile Gly Lys 
            420                 425                 430         


Ala Val Phe Asn Phe Ala Met Glu Asp Val Tyr Thr Ser Glu Val Arg 
        435                 440                 445             


Asp Ile Glu Leu Gly Lys Ile Thr Lys Ala Ala Ser Glu Gly Ile Thr 
    450                 455                 460                 


Ser Phe Asp Tyr Glu Tyr Ile Lys Ala Gly Glu Thr Leu Gln Arg Glu 
465                 470                 475                 480 


Thr Ala Val Ala Val Ala Phe Ala Ala Asn Asn Val Ala Arg Ser Ile 
                485                 490                 495     


Val Asn Ile Pro Glu Pro Phe Val Val Leu Asp Lys Asn Gly Lys Glu 
            500                 505                 510         


Lys Glu Ile Asp Met Ser Asp Phe Leu Leu Trp Glu Glu Lys Asp Ile 
        515                 520                 525             


Ser Asp Arg Leu Arg Ser Lys Glu Lys Tyr Asp Thr Val Gly Ser Ile 
    530                 535                 540                 


Leu Gln Phe Phe Gly Gly Lys Ser Lys Trp Asp Met Glu Val Phe Asp 
545                 550                 555                 560 


Gln Ala Tyr Asn Gly Asp Pro Asp Val Gly Phe Ala Ser Asp Ile Arg 
                565                 570                 575     


Lys Ala Ile Tyr Ser Leu Arg Asn Ser Ser Phe His Phe Thr Thr Ala 
            580                 585                 590         


Asn Ile Asp Lys Gly Ser Trp Asn Ile Ser Leu Ile Ala Ser Leu Phe 
        595                 600                 605             


Glu Lys Glu Ala Lys Phe Ala Leu Thr Ser Glu Lys Asn Lys Leu Tyr 
    610                 615                 620                 


Ser Asn Asn Leu Cys Met Phe Tyr Arg Lys Ser Asp Leu Lys Ala Ile 
625                 630                 635                 640 


Leu Asp Lys Leu Tyr Gly Lys Tyr Ser Ser Arg Ala Ser Gln Val Pro 
                645                 650                 655     


Ala Phe Asn Lys Val Phe Val Arg Lys Asn Phe Val Asn Glu Leu Lys 
            660                 665                 670         


Asn Met Gly Leu Ala Pro Ser Phe Thr Asp Asp Lys Thr Leu Leu Met 
        675                 680                 685             


Trp Gln Asn Ser Ile Tyr Tyr Leu Phe Lys Glu Ile Tyr Tyr Asn Ala 
    690                 695                 700                 


Phe Leu Thr Asp Pro Ala Val Lys Lys Leu Val Ile Asp Thr Val Tyr 
705                 710                 715                 720 


Glu Ile Lys Lys Asn Pro Met Ala Tyr Val Asn Asp Asn Lys Asn Asp 
                725                 730                 735     


Lys Asp Gln Thr Lys Ile Gly Arg Ala Ala Asn Asp Phe Ala Asp Arg 
            740                 745                 750         


Phe Ile Glu Leu Lys Asn His Arg Leu Glu Glu Ile Cys Gln Ile Ile 
        755                 760                 765             


Met Ser Glu Tyr Asn Leu Gln Asn Gln Gly Asn Arg Lys Lys Lys Thr 
    770                 775                 780                 


Ser Asn Ala Ser Pro Phe Asp Lys Asp Ile Phe Gln His Tyr Lys Met 
785                 790                 795                 800 


Leu Leu Met Lys Val Leu Met Ile Ser Phe Glu Lys Tyr Val Lys Ser 
                805                 810                 815     


Ser Phe Pro Gln Ile Ile Lys Thr Asp Asn Ala Val Tyr Glu Pro Gly 
            820                 825                 830         


Ser Val Glu Asp Phe Leu Pro Asn Trp Glu Ser Pro Met Tyr Asp Asp 
        835                 840                 845             


Leu Ile Lys Glu Val Gly Gln Asn Ala Glu Leu Gln Lys Trp Tyr Val 
    850                 855                 860                 


Val Ser His Phe Leu Asn Gly Lys Met Leu Asn Gln Leu Gly Gly Ser 
865                 870                 875                 880 


Val Arg Ser Tyr Ile Gln Tyr Val Gln Asp Ile Lys Arg Arg Ala Glu 
                885                 890                 895     


Glu Thr Gly Asn Lys Leu Cys Val Pro Asp Asn Thr Ile Lys Glu Asp 
            900                 905                 910         


Ile Lys Arg Cys His Lys Ile Val Glu Ile Ile Asp Leu Cys Val Arg 
        915                 920                 925             


Ser Ala Ser Asn Ile Ser His Glu Phe Thr Asp Tyr Phe Asn Asp Glu 
    930                 935                 940                 


Asp Asp Tyr Ala Leu Tyr Leu Ser Lys Tyr Leu Asp Tyr Gly Thr Ser 
945                 950                 955                 960 


Asp Ser Gly Leu Ser Thr Trp Ala Glu Leu Gly Arg Phe Cys Asn Asp 
                965                 970                 975     


Gly Glu Val Asn Tyr Gly Ile Tyr Arg Asp Ala Leu Asn Pro Ile Pro 
            980                 985                 990         


Asn Arg Asn Ile Val Met Ser Lys  Leu Tyr Gly Ala Asp  Thr Ile Ile 
        995                 1000                 1005             


Pro Lys  Val Ile Asn Arg Val  Asn Glu Asp Ile Ile  Lys Glu Tyr 
    1010                 1015                 1020             


Tyr Gln  Met Ile Lys Glu Ile  Asp Gln Tyr Arg Ile  Lys Gly Lys 
    1025                 1030                 1035             


Cys Asp  Ser Glu Asp Glu Gln  Lys Lys Leu Leu His  Phe Gln Lys 
    1040                 1045                 1050             


Ile Lys  Asn Lys Ile Glu Phe  Arg Asp Ile Val Glu  Tyr Ser Glu 
    1055                 1060                 1065             


Leu Ile  Asn Asp Leu Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Leu 
    1070                 1075                 1080             


Arg Glu  Arg Asp Leu Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Ala 
    1085                 1090                 1095             


Cys Leu  His Asn Lys Ser Arg  Lys Pro Glu Gly Tyr  Asp Ile Val 
    1100                 1105                 1110             


Lys Arg  Asn Asn Gly Thr Thr  Val Lys Gly Thr Ile  Leu Arg Gln 
    1115                 1120                 1125             


Ile Ala  Gly Leu Tyr Ile Asn  Gly Ile Gly Ile Leu  Asp Lys Thr 
    1130                 1135                 1140             


Thr Ser  Gly Asp Tyr Lys Glu  Ala Ala Gln Ala Gly  Gly Ser Phe 
    1145                 1150                 1155             


Gly Arg  Phe Tyr Ser Tyr Ser  Asn Lys Val Met Glu  Ser Thr Gly 
    1160                 1165                 1170             


Phe Tyr  Ala Pro Asp Asp Glu  Glu Gly Arg Lys Asn  Ser Leu Tyr 
    1175                 1180                 1185             


Leu Ala  Gly Leu Glu Leu Phe  Glu Asn Leu Asn Glu  His Glu Ser 
    1190                 1195                 1200             


Ile Val  Lys Lys Arg Asn Asp  Ile Asp His Phe Lys  Tyr Tyr Met 
    1205                 1210                 1215             


Gly Lys  Ala Gly Ser Leu Leu  Asp Leu Tyr Ser Glu  Val Phe Asp 
    1220                 1225                 1230             


Arg Phe  Phe Thr Tyr Asp Met  Lys Tyr Gln Lys Asn  Val Ile Asn 
    1235                 1240                 1245             


Met Leu  Glu Asn Ile Leu Met  Arg Tyr Phe Val Ile  Ile Ser Pro 
    1250                 1255                 1260             


Lys Val  Gly Ser Gly Thr Lys  Leu Leu Asp Asn Asn  Gly Lys Lys 
    1265                 1270                 1275             


Glu Arg  Ala Gln Ile Glu Ile  Ile Ser Ser Gly Ile  Cys Ser Asp 
    1280                 1285                 1290             


Glu Phe  Ser Tyr Glu Tyr Ser  Gly Gly Asn Val Lys  Thr Pro Ala 
    1295                 1300                 1305             


Arg Asn  Thr Glu Phe Leu Asn  Thr Val Ala Arg Ile  Leu Tyr Tyr 
    1310                 1315                 1320             


Pro Glu  Glu Ile Glu Ser Tyr  Ser Leu Val Lys Val  Gln Gly Glu 
    1325                 1330                 1335             


Phe Ser  Val Thr Arg Thr Asp  Gly Lys Asn Arg Tyr  Pro Glu Lys 
    1340                 1345                 1350             


Lys Asn  Gly Asn Asn Asn Asn  Gln Lys Asn Arg Gly  Asn Arg Gln 
    1355                 1360                 1365             


Asn Tyr  Gln Arg Asn Lys Asn  His Asn Asn Lys Lys  Ser Ser Met 
    1370                 1375                 1380             


Ser Glu  Thr Val Tyr Thr Ser  Ser Ser Pro Asn Glu  Ser Phe Gly 
    1385                 1390                 1395             


Tyr Asn  Pro Phe Arg Asp Leu  Pro Arg Asp Phe Lys  Met 
    1400                 1405                 1410     


<210>  452
<211>  1425
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  452

Met Lys Leu Ser Lys Val Asp Arg Ile Arg Val Ala Val Gly Lys Thr 
1               5                   10                  15      


Gly Lys Thr Glu Asn Gly Asn Ser Gln Gly Arg Gly Val Leu Tyr Arg 
            20                  25                  30          


Ser Pro Lys Gly Asn Lys Thr Val Ala Val Asp Ala Val Val Glu Glu 
        35                  40                  45              


Arg Ile Arg Asn Ala Asn Arg Leu Tyr Ser Ala Phe Phe Arg Cys Ala 
    50                  55                  60                  


Tyr Pro Glu Glu Pro Glu Arg His Phe Glu Glu Ile Ile Lys Arg Met 
65                  70                  75                  80  


Ala Thr Gly Lys Lys Ser Gly Ala Gln Ile Leu Lys Glu Tyr Ile Gly 
                85                  90                  95      


Tyr Glu Gly Gln Lys Asn Arg Lys Pro Tyr Thr Phe Tyr Val Asn Lys 
            100                 105                 110         


Cys Ala Tyr Arg Pro Ala Gly Lys Glu Leu Gly Gln Val Leu Arg Leu 
        115                 120                 125             


Phe Val Lys Glu Arg Leu Gly Gln Asn Trp Gln Asn Pro Glu Ala Ala 
    130                 135                 140                 


Glu Ala Ala Val Ala Leu Leu Thr Cys Leu Cys Glu Gly Lys Thr Asn 
145                 150                 155                 160 


Arg Tyr Thr Glu Asn Thr Ala Asp Gly Pro Val Leu Thr Glu Leu Ser 
                165                 170                 175     


Glu Gln Thr Val Thr Gln Leu Glu Gln Val Ser Arg Leu Gly Gly Ser 
            180                 185                 190         


Ile Leu Val Pro Lys Thr Glu Arg Leu Glu Thr Ile Val Thr Val Ile 
        195                 200                 205             


Leu Arg Leu Thr Ala Glu Gln Cys Asn Thr Ser Leu Tyr Val Asn Gly 
    210                 215                 220                 


Gly Thr Lys Glu Ala Gln Asp Ala Asp Leu Glu Lys Gln Ile Ala Leu 
225                 230                 235                 240 


Leu Lys Ser Leu Gln Thr Lys Pro Leu Leu Leu Lys Glu Arg Phe Asp 
                245                 250                 255     


Lys Val Thr Lys Gln Thr Ile Arg Asp Glu Gln Lys Leu Ser Glu Phe 
            260                 265                 270         


Ser Tyr Lys Asp Ala Thr Lys Glu Arg Met Glu Ala Val Val Val Arg 
        275                 280                 285             


Met Arg Lys Thr Leu Lys Lys Gly Ala Ser Arg Glu Val Ala Val Glu 
    290                 295                 300                 


Leu Leu Gln Ala Leu Ala Gln Tyr Asp Gly Lys Thr Trp Asp Gly Trp 
305                 310                 315                 320 


Leu Thr Gln Met Leu Glu Thr Glu Ala Ser Lys Lys Lys Leu Lys Asp 
                325                 330                 335     


Phe Ile Leu Ala Val Asn Lys Asp Phe His His Phe His Val Ile Lys 
            340                 345                 350         


Ser Val Lys Asn Thr Ala Val Ala Val Ser His Ser Glu Asp Asn Thr 
        355                 360                 365             


Leu Gln Leu Ser Gly Ala Lys Lys Lys Thr Lys Gly Ala Met Gln Asp 
    370                 375                 380                 


Ala Leu Phe Ala Tyr Ala Gln Ser Glu Glu Ser Ser Asp Glu Thr Leu 
385                 390                 395                 400 


His Arg Ile Lys Arg Ile Leu Phe Thr Tyr Val Leu Gly Gly Arg Gln 
                405                 410                 415     


Asp Asn Thr Leu Arg Leu Thr Glu Lys Thr His Leu Ala Lys Glu Leu 
            420                 425                 430         


Leu Trp Lys Phe Arg Gly Thr Gly Ala Gly Leu Phe Asp Ala Asp Phe 
        435                 440                 445             


Val Pro Glu Glu Glu Arg Ala Gly Glu Ser Gly Arg Lys Ala Gly Ser 
    450                 455                 460                 


Tyr Thr Asp Leu Gly Cys Leu Phe Ala Glu Asp Asp Gly Ile Arg Asn 
465                 470                 475                 480 


Gln Arg Arg Ile Ala Asp Arg Ile Asn Tyr Val Asn Tyr Gly Asn Tyr 
                485                 490                 495     


Leu Arg Met Arg Lys Ala Ala Glu Asp Glu Phe Thr Leu Phe Trp Cys 
            500                 505                 510         


Ala Tyr Ile Lys Asp Tyr Ile Glu Glu Asn Tyr Val Thr Lys Ile Arg 
        515                 520                 525             


Glu Ala Lys Arg Thr Gly Gly Lys Arg Arg Leu Lys Glu Thr Asp Cys 
    530                 535                 540                 


Glu Ala Glu Arg Met Met Glu Lys Cys Trp His Asp Ile Ile Arg Tyr 
545                 550                 555                 560 


Ile Cys Gly Lys Tyr Ile His Ile Gly Lys Ala Val Tyr His Phe Ala 
                565                 570                 575     


Ile Pro Glu Asp Leu Leu Ala Asn Pro Gly Glu Val Arg Ser Phe Gly 
            580                 585                 590         


Asp Val His Ala Lys Tyr Ala Asp Gly Ile Thr Ser Phe Asp Tyr Glu 
        595                 600                 605             


Asp Ile Lys Ala Glu Glu Asn Leu Gln Lys Ser Ile Phe Asn Val Leu 
    610                 615                 620                 


Val Ser Ala Val Ala Asn Tyr Ser Arg Ser Val Val Asp Leu Ser Ser 
625                 630                 635                 640 


Glu Arg Ala Glu Glu Leu Arg Arg Leu Pro Gly Asn Glu Arg Leu Asn 
                645                 650                 655     


Glu Asp Val Leu Met Met Lys Glu Thr His Leu Lys Glu Leu Leu Leu 
            660                 665                 670         


Pro Asp Ala Lys Lys Arg Leu Leu Arg Tyr Phe Gly Gly Tyr Ser Ala 
        675                 680                 685             


Cys Glu Gly Leu Ser Gly Val Thr Ser Glu Glu Leu Ala Trp Glu Met 
    690                 695                 700                 


Arg Thr Val Leu Ser Thr Leu Arg Asn Glu Ser Phe His Tyr Thr Phe 
705                 710                 715                 720 


Gly Lys Lys Lys Lys Leu Asp Tyr Lys Val Ala Lys Gln Leu Trp Met 
                725                 730                 735     


Gln Ala Ile Arg Ala Asn Arg Gln Leu Ile Leu Asp Lys Tyr Tyr Ser 
            740                 745                 750         


Asn Asn Thr Cys Arg Tyr Tyr Ser Pro Asn Ser Ile Lys Ala Leu Ile 
        755                 760                 765             


Glu Gln Gly Tyr Arg Ser Tyr Glu Glu Arg Glu Ala Gln Ile Pro Ala 
    770                 775                 780                 


Phe Lys Thr Val Trp Lys Lys Ala Glu Leu Ala Lys Tyr Leu Ala Asp 
785                 790                 795                 800 


Lys Lys Val Met Pro Ala Glu Ile Ser Gly Glu Glu Lys Glu Arg Val 
                805                 810                 815     


Ile Phe Gln Gly Ala Phe Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg 
            820                 825                 830         


Glu Phe Thr Val Gly Asn Thr Ala Ala Lys Tyr Phe Phe Asp Ala Val 
        835                 840                 845             


Glu Arg Tyr Cys Lys Glu Asn Glu Thr Gly Pro Tyr Lys Asn Pro Ala 
    850                 855                 860                 


Lys Ser Phe Asn Asp Tyr Val Asn Gly Ala Phe Asn Asn Lys Gly Val 
865                 870                 875                 880 


Lys Val Gln Lys Gly Leu Ser Asp Leu Tyr Arg Glu Gly Lys Ile Thr 
                885                 890                 895     


Phe Gly Val Val Cys Gln Thr Ile Met Ala Glu Tyr Thr Gln Gln Asn 
            900                 905                 910         


Glu Lys Ser Glu Gly Glu Ala Ile Tyr Gln His Phe Lys Met Leu Phe 
        915                 920                 925             


Pro Leu Cys Met Arg Lys Gly Phe Gln Lys Tyr Val Glu Glu Lys His 
    930                 935                 940                 


Lys Glu Leu Leu Gln Pro Val Ile Arg Glu Met Gly Ser Arg Glu Asp 
945                 950                 955                 960 


Phe Leu Thr Asn Ile His Ile Gly Cys Phe Asp Asp Phe Cys Arg Glu 
                965                 970                 975     


Asp Gly Met Tyr Glu Tyr Asp Trp Phe Val Val Ala His Leu Ile His 
            980                 985                 990         


Pro Lys Arg Leu Asn Glu Leu Val  Gly Asn Leu Lys Asp  Tyr Met Gln 
        995                 1000                 1005             


Phe Lys  Gln Asp Ile Leu Arg  Arg Ala Asp Tyr Val  Glu Gln Phe 
    1010                 1015                 1020             


Thr Lys  Glu Glu Leu Ala Ala  Met Lys Ala Arg Thr  Glu Glu Lys 
    1025                 1030                 1035             


Leu Gln  Lys Ile Ser Gly Ile  Leu Arg Val Ala Glu  Phe Val Arg 
    1040                 1045                 1050             


Gly Ile  Ala Gly Arg Val Ser  Asn Thr Phe Ser Asp  Tyr Tyr Glu 
    1055                 1060                 1065             


Ser Glu  Glu Ala Tyr Ala Ser  Tyr Leu Glu Gln Tyr  Ile Glu Phe 
    1070                 1075                 1080             


Pro Arg  Ile Lys Gly Ser Thr  Val Phe Glu Ser Phe  Arg Asp Phe 
    1085                 1090                 1095             


Cys Val  Asn Thr Leu Pro Gly  Gly Ala Val Met Asp  Val Tyr Met 
    1100                 1105                 1110             


Asp Glu  Lys Asn Pro Arg Ile  Leu Arg Asn Val Glu  Val Ala Arg 
    1115                 1120                 1125             


Met Tyr  Ala Gly Gly Asp Ile  Gly Leu Arg Thr Arg  Lys Lys Val 
    1130                 1135                 1140             


Thr Ala  Glu Glu Leu Lys Arg  Tyr Tyr Gln Asn Glu  Ala Glu Val 
    1145                 1150                 1155             


Ala Ala  Leu Leu Lys Ala Gly  Leu Cys Ala Thr Ala  Glu Asp Gln 
    1160                 1165                 1170             


Lys Arg  Val Lys Ala Gln Gln  Glu Leu Arg Asn Arg  Ile Thr Leu 
    1175                 1180                 1185             


Thr Asp  Val Thr Glu Ile Gln  Glu Val Ile Asn Asp  Leu Leu Ser 
    1190                 1195                 1200             


Gln Leu  Val Thr Phe Ser Tyr  Phe Arg Glu Arg Asp  Glu Met Tyr 
    1205                 1210                 1215             


Leu Leu  Leu Gly Phe Tyr Tyr  Met Ala Leu Gln Ser  Asp Gly Asp 
    1220                 1225                 1230             


Trp Gly  Glu Glu Leu Arg Val  Phe Asp Gly Lys Lys  Leu Gln Val 
    1235                 1240                 1245             


Glu Asn  Gly Phe Val Leu Tyr  Gln Leu Leu Ser Ala  Phe Thr Tyr 
    1250                 1255                 1260             


Gly Leu  Asn Met Tyr Ser Glu  Ala Ala Pro Asp Gly  Lys Gly Gly 
    1265                 1270                 1275             


Ser Gln  Ala Gly Lys Ile Gly  Glu Phe Ile Lys Ala  His Pro Asn 
    1280                 1285                 1290             


Ser Trp  Asp Arg Ala Leu Arg  Leu Phe Val Asp Asp  Gly Ala Cys 
    1295                 1300                 1305             


Glu Glu  Val Ser Arg Lys Ala  Arg Asn Tyr Val Asp  His Phe Arg 
    1310                 1315                 1320             


Tyr Tyr  Val Lys Pro Asp Arg  Ser Ile Met Asp Leu  Tyr Ala Val 
    1325                 1330                 1335             


Tyr His  Glu Tyr Phe Phe Asp  Tyr Ser Thr Lys Met  Arg Lys Ser 
    1340                 1345                 1350             


Val Leu  Gln Asn Phe Ala Ser  Ile Leu Glu Arg Tyr  Phe Val Leu 
    1355                 1360                 1365             


Thr Lys  Phe Lys Leu Gly Gly  Glu Arg Gly Ala Gln  Thr Leu Glu 
    1370                 1375                 1380             


Ala Glu  Leu Ser Gly Asp Lys  Phe Thr Tyr Lys Leu  Ser Asp Thr 
    1385                 1390                 1395             


Lys Ala  Lys Pro Val Val Leu  Pro Ala Arg Asn Lys  Glu Phe Leu 
    1400                 1405                 1410             


Glu Asn  Leu Lys Asn Glu Leu  Asn Tyr Arg Gln Glu  
    1415                 1420                 1425 


<210>  453
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  453

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Thr Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Asp Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Ser Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val His Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1400                 1405                 1410         


<210>  454
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  454

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Thr Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Asp Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val His Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1400                 1405                 1410         


<210>  455
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  455

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Leu Gly Thr Asp Thr 
            20                  25                  30          


Ile Gly Leu Lys Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Asp Lys Pro Lys Lys 
    50                  55                  60                  


Trp Lys Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Glu Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Ser Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Met Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Tyr Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ser Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Lys Asp Arg Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Lys Glu Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Gln Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Phe 
            660                 665                 670         


Ile Arg Lys Asn Phe Pro Glu Asp Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Asp Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asn Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ser 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Asp Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Asp Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asn  Ser Glu Lys Lys Glu  Ala Tyr Gln Lys Ile  Glu Val Asn 
    1100                 1105                 1110             


Gly Asp  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Val  Tyr Ala Pro Asp Glu  Lys Gly Asp 
    1130                 1135                 1140             


Ile Leu  Lys Glu Gln Cys Thr  Lys Gly Gly Ala Gly  Gly Lys Ile 
    1145                 1150                 1155             


Ser Ala  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Lys Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Lys Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Lys Gln 
    1250                 1255                 1260             


Thr Thr  Ser Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Ser Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Lys  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Val Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Gly Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Pro Asn 
    1370                 1375                 1380         


<210>  456
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  456

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Leu Tyr Gln Ile Val  Ser Ala Phe Asn Phe  Gly Ser Lys 
    1205                 1210                 1215             


Leu Leu  Tyr Ile Ser Glu Asp  Gly Arg Trp Lys Met  Ala Gly Gly 
    1220                 1225                 1230             


Ala Phe  Pro Gly Lys Tyr Gly  Arg Phe Glu Asn Asp  Tyr Asn His 
    1235                 1240                 1245             


Arg Thr  Ser Leu Ser Lys Val  Ile Arg Leu Phe Glu  Asn Glu Ser 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ile Ile Tyr  Trp Arg Asp Tyr Val  Asp His Met 
    1265                 1270                 1275             


Lys Tyr  Tyr Val Asn Gln Asn  Gln Ser Ile Met Glu  Ile Tyr Ser 
    1280                 1285                 1290             


Ala Phe  Tyr Ser Lys Val Leu  Gly Tyr Ser Ala Lys  Leu Arg Lys 
    1295                 1300                 1305             


Ser Val  Val Phe Asn Leu Gln  Ala Ala Leu Glu Lys  His His Ile 
    1310                 1315                 1320             


Asn Pro  Glu Cys Ile Trp Met  Thr Ser Asp Gly Lys  Cys Ala Asp 
    1325                 1330                 1335             


Ile Lys  Leu Met Lys Asn Leu  Glu Ser Gln Lys Phe  Thr Tyr Lys 
    1340                 1345                 1350             


Leu Ala  Lys Arg Glu Gly Glu  Lys Thr Glu Arg Lys  Ile Cys Met 
    1355                 1360                 1365             


Asn Ala  Leu Asn Glu Asn Phe  Leu Lys Thr Ile Arg  Thr Ser Leu 
    1370                 1375                 1380             


Glu Tyr  Lys Lys 
    1385         


<210>  457
<211>  1177
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  457

Met Gly Thr Gly Lys Tyr Arg Ile Thr Lys Ile Gly Arg Asn Trp Lys 
1               5                   10                  15      


Glu Asn Glu Asn Lys Asn Lys Lys Arg Ile Ile Leu Lys Arg Ile Val 
            20                  25                  30          


Ser Asp Gly Glu Val Lys Tyr Val Asn Glu Asn Asp Asn Val Asp Ile 
        35                  40                  45              


Asp Ile Thr Glu Thr Tyr Tyr Gly Ile Leu Ser Asn Asn Lys Ala Lys 
    50                  55                  60                  


Phe Leu Gly Ser Asn Glu Gln Phe Leu Phe Lys Val Asn Lys Met Asp 
65                  70                  75                  80  


Arg Asn Ile Lys Asn Asp Tyr Val Ile Ile Lys Asp Tyr Thr Glu Glu 
                85                  90                  95      


Glu Phe Glu Lys Phe Asp Lys Lys Ile Phe Phe Ser Arg Lys Ile Lys 
            100                 105                 110         


Ile Asn Asn Glu Asp Arg Glu Lys Ile Cys Arg Asn Phe Tyr Glu Asp 
        115                 120                 125             


Glu Arg Glu Ile Met Lys Lys Arg Leu Glu Glu Ala Lys Asn Phe Asn 
    130                 135                 140                 


Asn Ile Ile Phe Asn Ile Cys Asn Lys Ile Phe Lys Leu Glu Tyr Leu 
145                 150                 155                 160 


Asp Tyr Thr Asp Glu Lys Val Tyr Lys Ile Phe Gln Lys Glu Ile Lys 
                165                 170                 175     


Phe Glu Asp Ile Lys Asn Leu Lys Glu Ala Phe Lys Lys Gln Glu Asn 
            180                 185                 190         


Gly Leu Glu Thr Asp Lys Leu Leu Ala Ile Ser Phe Asn Lys Lys Arg 
        195                 200                 205             


Asn Asn Ile Leu Leu Glu Phe Ile Gln Gln Ile Val Arg Gln Lys Phe 
    210                 215                 220                 


Glu Lys Glu Lys Glu Leu Glu Asn Trp Phe Ser His Glu Gly Glu Lys 
225                 230                 235                 240 


Tyr Cys Lys Glu Ile Phe Lys Ile Tyr Ser Asn Met Ser Gln Lys Glu 
                245                 250                 255     


Lys Tyr Ser Lys Leu Leu Gly His Arg Asn Lys Asn Ile Ala Ser Ile 
            260                 265                 270         


Ser Glu Lys Lys Glu Thr Leu Gln Arg Arg Leu Lys Leu Gly Asn Tyr 
        275                 280                 285             


Ser Asp Tyr Asp Leu Arg Lys Tyr Tyr Gln Lys Asp Tyr Lys Glu Glu 
    290                 295                 300                 


Ala Ile Lys Glu Leu Lys Asp Lys Asn Lys Glu Glu Leu Glu Arg Glu 
305                 310                 315                 320 


Ile Glu Glu Leu Ile Lys Lys Asn Tyr Lys Ile Asp Lys Leu Cys Asp 
                325                 330                 335     


Glu Ile Ser Asn Leu Glu Phe Phe Phe Val Glu Ser Lys Lys Glu Asn 
            340                 345                 350         


Lys Asp Lys Met Ser Glu Ile Ile Val Lys Ile Lys Glu His Tyr Lys 
        355                 360                 365             


Lys Asn Val Asn Val Glu Glu Glu Leu Lys Asn Lys Glu Lys Tyr Ile 
    370                 375                 380                 


Leu Ser Leu Ile His Asn Tyr Val Lys Gly Arg Tyr Arg Lys Cys Leu 
385                 390                 395                 400 


Glu Leu Gln Gln Lys Glu Asn Val Asp Phe Glu Asn Leu Gly Lys Arg 
                405                 410                 415     


Ile Lys Glu Ile Phe Asp Ser Asn Glu Val Thr Lys Lys Leu Lys Lys 
            420                 425                 430         


Ser Ile Ile Asn Lys Val Asn Ser Tyr Lys Ile Phe Glu Met Lys Phe 
        435                 440                 445             


Gln Asn Pro Asn Ile Glu Ser Ser Asp Asp Leu Glu Ile Leu Lys Ala 
    450                 455                 460                 


Glu Glu Thr Phe Leu Asn Lys Leu Ser Thr Ala Val Ser Lys Val Gly 
465                 470                 475                 480 


Tyr Thr Leu Asn Ile Leu Leu Gly Val Ser Ser Glu Glu Asp Ile Leu 
                485                 490                 495     


Lys Asn Tyr Asn Met Val Gly Lys Leu Cys Asn Asn Asn Ser Thr Thr 
            500                 505                 510         


Glu Ile Tyr Lys Val Tyr Pro Glu Leu Glu Lys Asn Glu Lys Leu Leu 
        515                 520                 525             


Gln Gly Met Ile His Phe Ile Gln Gly Leu Arg Gln Gln Ser Leu His 
    530                 535                 540                 


Pro Lys Ile Ser Trp Asn Phe Glu Thr Glu Asn Leu Lys Pro Glu Lys 
545                 550                 555                 560 


Leu Glu Arg Leu Lys Glu Lys Lys Asn Ile Lys Ile Arg Asp Cys Val 
                565                 570                 575     


Val His Glu Tyr Asn Leu Asp Lys Lys Glu Lys Asn Glu Val Glu Ile 
            580                 585                 590         


Lys Glu Tyr Phe Glu Lys Ile Glu Lys Lys Leu Pro Asn Tyr Phe Ile 
        595                 600                 605             


Glu Lys Tyr Glu Ser Asn Asn Val Phe Asn Ile Tyr Arg Asp Ser Val 
    610                 615                 620                 


Asp Lys Ile Met Glu Val Val Lys Lys Phe Asn Phe Lys Glu Asp Asn 
625                 630                 635                 640 


Thr Ile Asp Tyr Leu Phe Pro Lys Phe His Lys Ile Tyr Lys Lys Met 
                645                 650                 655     


Cys Lys Leu Glu Asn Ile Thr Cys Lys Ser Glu Asn Thr Asp Asp Arg 
            660                 665                 670         


Gln Asn Gly Ala Arg Lys Tyr Leu Leu Gln Thr Ile Tyr Tyr Tyr Tyr 
        675                 680                 685             


Phe Gln Tyr Glu Ile Glu Asn Asn Arg Asn Asn Ile Phe Lys Tyr Tyr 
    690                 695                 700                 


Arg Asn Lys Ile Lys Thr Glu Lys Asn Ser Tyr Arg Asp Lys Asn Ile 
705                 710                 715                 720 


Glu Ile Leu Tyr Arg Asn Ile Gln Arg Glu Gly Met Leu Asn Asn Arg 
                725                 730                 735     


Leu Leu Gln Met Asn Asn Glu Trp Ile Glu Phe Ile Met Ile Gln Phe 
            740                 745                 750         


Ile Glu Phe Ile Ser Ile Lys Lys Leu Asn Trp Ile Leu Asp Asp Leu 
        755                 760                 765             


Ser Glu Tyr Arg Lys Lys Glu Lys Leu Asp Glu Asn Asp Lys Asn Arg 
    770                 775                 780                 


Leu Leu Lys Ile Leu Lys Gln Lys Met Asn Lys Asn Ile Thr Tyr Ser 
785                 790                 795                 800 


Asn Asp Ser Tyr Val Phe Ile Ser Leu Ala Gln Phe Leu Asp Leu Lys 
                805                 810                 815     


Glu Ile Ser Asn Leu Ile His Asp Ile Lys Lys Phe Val Gln Phe Arg 
            820                 825                 830         


Glu Lys Asn Ile Ser Lys Tyr Lys Pro Glu Lys Asn Lys Val Tyr Ile 
        835                 840                 845             


Glu Glu Leu Arg Lys Ile Ser Tyr Ile Leu Lys Val Met Leu Glu His 
    850                 855                 860                 


Lys Glu Arg Val Ile Gln Lys His Tyr Leu Glu Ser Tyr Asp Glu Asp 
865                 870                 875                 880 


Ile Ser Ile Met Tyr Gly Lys Asp Ile Glu Lys Lys Asp Ile Lys Asp 
                885                 890                 895     


Ile Glu Ile Lys Ile Lys Asn Lys Asn Gln Glu Val Ile Asn Gln Pro 
            900                 905                 910         


Leu Tyr Lys Ser Gly Asn Asp Gly Asn Ser Ser Trp Ile Val Leu Tyr 
        915                 920                 925             


Gly Ile Glu Gln Ala Lys Arg Asn Gly Thr Phe Lys Phe Phe Glu Gly 
    930                 935                 940                 


Phe Phe Asn Leu Asn Glu Asp Ile Lys Leu Cys Lys Lys Asp Ile Lys 
945                 950                 955                 960 


Lys Tyr Glu Lys Leu Tyr Asn Glu Lys Glu Glu Asn Gln Lys Lys Val 
                965                 970                 975     


Asp Glu Tyr Ile Phe Tyr Glu Arg Asn Ser Tyr Ile Glu Lys Val Asn 
            980                 985                 990         


Asn Asn Ile Asn Ile Glu Lys Thr  Asn Asn Asn Lys Gln  Leu Phe Tyr 
        995                 1000                 1005             


Tyr Tyr  Lys Asn Met Ile Tyr  Gly Asp Gly Leu Lys  Lys Gly Tyr 
    1010                 1015                 1020             


Asp Phe  Ile Asn Asp Ile Tyr  Ser His Tyr Leu Ser  Trp Ala Tyr 
    1025                 1030                 1035             


Arg Ile  Glu Arg Asp Cys Lys  Ile Tyr Lys Ile Lys  Glu Tyr Glu 
    1040                 1045                 1050             


Asn Lys  Lys Asn Phe Asn Glu  Tyr Lys Phe Lys Glu  Tyr Lys Ser 
    1055                 1060                 1065             


Ile Lys  Asn Phe Arg Asn Glu  Ile Ala His Phe Asn  Tyr Phe Gln 
    1070                 1075                 1080             


Lys Thr  Asn Lys Ser Leu Leu  Glu Leu Leu Asn Asn  Phe Tyr Asp 
    1085                 1090                 1095             


Ile Phe  Asp Tyr Asn Leu Lys  Tyr Gln Arg Asp Val  Gln Lys Val 
    1100                 1105                 1110             


Ile Asn  Asn Ile Phe Glu Lys  Tyr Gln Val Ile Arg  Glu Asp Gly 
    1115                 1120                 1125             


Gly Pro  Val Ile Phe Tyr Cys  Lys Ile Glu Lys Lys  Leu Lys Leu 
    1130                 1135                 1140             


Ser Glu  Asn Ile Ile Pro Lys  Lys His Ser Lys Tyr  Pro Glu Ile 
    1145                 1150                 1155             


Lys Leu  Ile His Glu Lys Tyr  Val Glu Phe Phe Lys  Lys Leu Phe 
    1160                 1165                 1170             


Glu Tyr  Lys Lys 
    1175         


<210>  458
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  458

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Ser Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Val Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Thr Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Lys Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Val Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Lys Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Lys Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Val Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Leu Lys Glu Leu Lys Glu Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn Tyr Arg Met Gln Gln Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Lys Lys Asp Glu Lys Phe Asn Asp Lys Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Thr Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Glu Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Lys  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  459
<211>  1353
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  459

Met Lys Val Thr Lys Ala Glu Lys Leu Arg Val Ala Val Ser Arg Lys 
1               5                   10                  15      


Leu Asn Asn Glu Asp Lys Arg Ala Val Leu Tyr Lys Thr Pro Asn Pro 
            20                  25                  30          


Gly Gln Thr Cys Gly Thr Val Lys Lys Gln Leu Ala Asn Arg Val Glu 
        35                  40                  45              


Arg Ala Asn Lys Leu Tyr Gly Val Phe Phe Arg Ser Asp Val Pro Glu 
    50                  55                  60                  


Thr Leu Gln Tyr His Phe Glu Glu Leu Val Thr Tyr Ala Ala Gln Ser 
65                  70                  75                  80  


Thr Ser Pro Asn Glu Phe Arg Gln Lys Ala Ser Gln Tyr Arg Glu Cys 
                85                  90                  95      


Glu Lys Lys Asp Lys Phe Gly Lys Met Arg Lys Tyr Pro Ile Phe Arg 
            100                 105                 110         


Cys Ser Tyr Ala Pro Ser Gly Lys Asn Met Lys Lys Val Met Glu Leu 
        115                 120                 125             


Tyr Val Arg Glu Arg Met Lys Asp Glu Trp Gln Ser Gln Ala Tyr Arg 
    130                 135                 140                 


Thr Ala Ala Ile Glu Ile Leu Leu Cys Ile Cys Asn Lys Asp Phe Ser 
145                 150                 155                 160 


Lys Gln Leu Ser Arg Val Asp Ala Arg Ile Phe Ala Asp Phe Tyr Asn 
                165                 170                 175     


Ala Ser Lys Ala Cys Pro Gln Pro Tyr Ile Gly Lys Ser Thr Gly Val 
            180                 185                 190         


Leu Glu Ala Ala Phe Thr Ser Val Met Lys Gln Met Ser Leu His Ala 
        195                 200                 205             


Lys Ala Asn Ala Ser Asn Lys Ile Trp Trp Leu Gln Asn Gln Leu Arg 
    210                 215                 220                 


Thr Ile Glu Leu Asn Lys Lys Ile Val Lys Ile Ser Asp Phe Lys Tyr 
225                 230                 235                 240 


Glu Tyr Ala Thr Glu Asp Arg Met Arg Ala Ile Leu Val Arg Met Arg 
                245                 250                 255     


Lys Ser Leu Lys Arg Gly Thr Asn Gly Asp Ile Ala Val Ala Leu Leu 
            260                 265                 270         


Gln Gly Ile Ala Gln Met Asn Gly Lys Thr Leu Ser Gly Val Leu Glu 
        275                 280                 285             


Glu Leu Ser Ala Asn Ser Glu Thr Lys Glu Gln Leu Ile Lys Phe Leu 
    290                 295                 300                 


Lys Ala Val His Glu Asp Tyr His Lys Thr Pro Ile Leu Lys Ala Ile 
305                 310                 315                 320 


Arg Asn Gln Asp Val Lys Val Gln Val His Glu Val Asp Pro Val Ser 
                325                 330                 335     


Pro Glu Gly Arg Ala Leu Asp Leu Ala Ser Ile Asn Val Ser Lys Gly 
            340                 345                 350         


Asn Glu Arg Lys Lys Tyr Lys Val Ala Leu Thr Gln Thr Leu Gly Asn 
        355                 360                 365             


Tyr Ala Lys Ser Pro Lys Asp Ala Thr Gln Thr Leu Lys Ala Ile Lys 
    370                 375                 380                 


Gly Val Leu Leu Asp Tyr Phe Met Trp Leu Asp Ser Asp Val Lys Ala 
385                 390                 395                 400 


Glu Phe Leu Glu Asp Asn Asn Leu Trp Lys Ile Pro Asn Arg Thr Glu 
                405                 410                 415     


Glu Tyr Phe Asp Asn Asn Phe Val Pro Ile Asp Asp Lys Lys Asp Asp 
            420                 425                 430         


Lys Ile Glu Ala Ile Glu Asp Phe Ala Ser Ile Trp Arg Gln Glu Arg 
        435                 440                 445             


Val Lys Asn Ser Arg Ile Lys Ala Arg Met Asn Tyr Val Asn Cys Gly 
    450                 455                 460                 


Lys Tyr Gln Gln Leu Ile Lys Gln Glu Thr Asp Asp Phe Arg Ile Cys 
465                 470                 475                 480 


Trp Ile Ser Tyr Ala Lys Asp Phe Val Glu Lys Asn Tyr Val Ser Lys 
                485                 490                 495     


Asn Arg Gln Phe Thr Gln Gly Asp Cys Phe Ser Thr Lys Met Leu Leu 
            500                 505                 510         


Glu Cys Trp Lys Glu Ile Ile Arg Phe Ile Cys Gly Lys Tyr Ile Asp 
        515                 520                 525             


Ile Gly Lys Ala Val Tyr His Phe Ala Met Pro Glu Thr Met Asn Ala 
    530                 535                 540                 


Arg Asp Ser Leu Ala Tyr Gly Val Leu Gly Glu Lys Tyr Lys Glu Gly 
545                 550                 555                 560 


Ile Ser Ser Phe Asp Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln 
                565                 570                 575     


Arg Asp Ile Ala Lys Ala Ala Val Ala Ala Ile His Ala Phe Ser Gly 
            580                 585                 590         


Ser Val Ile Asp Asp Lys Lys Pro Val Glu Asp Ile Leu Phe Ile Lys 
        595                 600                 605             


Asp Glu Glu Leu Gln Glu His Ala Lys Ala Asp Asp Val Ile Val Lys 
    610                 615                 620                 


Gln Ile Leu Arg Phe Tyr Gly Gly Phe Ser Ser Val Glu Gly Arg Glu 
625                 630                 635                 640 


Lys Leu Glu Gly Met Ala Leu Ala Lys Glu Val Leu Ser Gln Leu Lys 
                645                 650                 655     


Ala Ile Arg Asn Glu Asn Phe His Phe Thr Gln Gly Lys Arg Lys Asn 
            660                 665                 670         


Val Glu Glu Asn Ile Pro Leu Thr Lys Ala Leu Trp Glu Asn Glu Glu 
        675                 680                 685             


Lys Val Tyr Arg Gln Thr Val Lys Glu Thr Tyr Tyr Ser Asn Asn Val 
    690                 695                 700                 


Ser Met Phe Tyr Ser Gln Glu Val Ile Gln Lys Leu Val Ala Glu Leu 
705                 710                 715                 720 


Tyr Gln Asn Asn Asn Val Ala Glu Ala Gln Ile Pro Ala Phe Arg Thr 
                725                 730                 735     


Ile Trp Lys Arg Lys Asp Leu Pro Glu Tyr Ile Gly Ser Leu Asn Ile 
            740                 745                 750         


Ser Trp Asp Lys Thr Glu Pro Lys Gln Val Ile Tyr Glu Gly Ala Leu 
        755                 760                 765             


Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Lys Ser Gly 
    770                 775                 780                 


Glu Ala Lys Lys Leu Phe Phe Asp Ala Val Met Asp Asn Ala Thr Glu 
785                 790                 795                 800 


Met Glu Lys Ser Ser Asn Ala Asp Ser Arg Asn Gln Glu Lys Lys Ala 
                805                 810                 815     


Leu Ala Asn Ala Gly Lys Asn Phe Arg Asp Tyr Val Asn Gly Leu Asn 
            820                 825                 830         


Ala Ser Thr Leu Gly Glu Val Cys Gln Phe Ile Gln Asn Glu Tyr Asn 
        835                 840                 845             


Gln Gln Asn Arg Gly Lys Gln Glu Gln Glu Ile Tyr Lys His Phe Lys 
    850                 855                 860                 


Met Leu Leu Pro Ile Cys Met Arg Lys Ala Phe Gln Arg Tyr Ile Asp 
865                 870                 875                 880 


Glu Lys His Ser Phe Ile Lys Lys Pro Gly Glu Leu Pro Gln Thr Thr 
                885                 890                 895     


Glu Asp Tyr Leu Glu Asn Val Lys Val Ala Cys Pro Glu Lys Lys Ile 
            900                 905                 910         


Lys Leu Gly Arg Trp Phe Thr Phe Ala His Phe Ile His Pro Arg Glu 
        915                 920                 925             


Leu Asn Phe Leu Ile Gly Asp Phe Lys Asn Tyr Ile Gln Tyr Arg Glu 
    930                 935                 940                 


Asp Val Leu Arg Arg Ser Glu His Ala Gly Gln Phe Ser Asp Thr Thr 
945                 950                 955                 960 


Glu Arg Asp Gly Glu Lys Ala Val Val Asp His Ala Val Gln Lys Ala 
                965                 970                 975     


Lys Asp Ile Leu Gly Val Leu Glu Phe Val Arg His Ile Ser Gly Arg 
            980                 985                 990         


Val Ser Asn Glu Phe Thr Asp Tyr  Tyr Ala Asp Arg Ala  Glu Tyr Asp 
        995                 1000                 1005             


Glu Tyr  Met Ala Lys Tyr Phe  Glu Pro Asp Val Gln  Ile Glu Gln 
    1010                 1015                 1020             


Tyr Asp  Leu Tyr Gly Asp Ala  Lys Asn Ala Lys Val  Ile Arg Asn 
    1025                 1030                 1035             


Ile Glu  Leu Ala Arg Met Tyr  Ala Gly Asp Ser Leu  Met Ser Ala 
    1040                 1045                 1050             


Ser Tyr  Arg Lys Ile Thr Lys  Lys Glu Ile Glu Thr  Tyr Tyr Ala 
    1055                 1060                 1065             


Lys Lys  Asp Glu Ile Ala Gln  Leu Gln Ser Gln Gly  Ile Cys Asn 
    1070                 1075                 1080             


Ser Lys  Lys Glu Gln Glu Asp  Ile Val Ala Phe Gln  Lys Leu Lys 
    1085                 1090                 1095             


Asn Arg  Ile Thr Leu Asn Glu  Val Thr Asp Leu Trp  Ser Leu Val 
    1100                 1105                 1110             


Asn Glu  Leu Leu Gly Asn Leu  Val Ser Leu Ala Tyr  Leu Arg Glu 
    1115                 1120                 1125             


Arg Asp  Glu Met Tyr Leu Phe  Leu Gly Phe Tyr Tyr  Met Ala Leu 
    1130                 1135                 1140             


Arg His  Pro Glu Gly Trp Thr  Asn Glu Ile Met Asn  Ser Val Ser 
    1145                 1150                 1155             


Asn Glu  Lys Tyr Ala Val Lys  Glu Gly Leu Val Leu  Tyr Gln Thr 
    1160                 1165                 1170             


Val Ala  Val Phe Asp Phe Gly  Thr Lys Leu Leu Phe  Gln Asn Asp 
    1175                 1180                 1185             


Asn Gln  Lys Trp Glu Glu Thr  Thr Gly Tyr Lys Trp  Gln His Phe 
    1190                 1195                 1200             


Ile Asp  Asn His Lys Glu Ser  Tyr Ala Cys Ile Leu  Pro Leu Phe 
    1205                 1210                 1215             


Glu Ile  Ala Lys Cys Glu Thr  Glu Ala Arg Ala Val  Arg Asn Tyr 
    1220                 1225                 1230             


Val Asp  His Phe Lys Tyr Tyr  Ser Asn Glu Asp Arg  Ser Ile Leu 
    1235                 1240                 1245             


Glu Leu  Tyr Gly Lys Phe Tyr  Thr His Leu Phe Gly  Tyr Ser Thr 
    1250                 1255                 1260             


Arg Leu  Arg Lys Ser Val Leu  Gln Ile Leu Ala Gln  Thr Leu Glu 
    1265                 1270                 1275             


Lys His  Gly Ile Ser Ala Gly  Ile Gln Phe Asp Gly  Thr Thr Val 
    1280                 1285                 1290             


Lys Ala  Thr Arg Cys Asp Met  Lys Ser Val Glu Phe  Thr Tyr Lys 
    1295                 1300                 1305             


Tyr Glu  Glu Lys Leu Asn Glu  Gln Lys Thr Val Leu  Arg Thr Ile 
    1310                 1315                 1320             


Ser Leu  Pro Ala Lys Ser Glu  Gly Phe Ile Thr Ala  Val Cys Glu 
    1325                 1330                 1335             


Met Leu  Lys Gln Lys Lys Gly  Asp His Thr Glu Asn  Thr Leu Cys 
    1340                 1345                 1350             


<210>  460
<211>  1353
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  460

Met Lys Val Thr Lys Ala Glu Lys Leu Arg Val Ala Val Ser Arg Lys 
1               5                   10                  15      


Leu Asn Asn Glu Asp Lys Arg Ala Val Leu Tyr Lys Thr Pro Asn Pro 
            20                  25                  30          


Gly Gln Thr Cys Gly Thr Val Lys Lys Gln Leu Ala Asn Arg Val Glu 
        35                  40                  45              


Arg Ala Asn Lys Leu Tyr Gly Val Phe Phe Arg Ser Asp Val Pro Glu 
    50                  55                  60                  


Thr Leu Gln Tyr His Phe Glu Glu Leu Val Thr Tyr Ala Ala Gln Ser 
65                  70                  75                  80  


Thr Ser Pro Asn Glu Phe Arg Gln Lys Ala Ser Gln Tyr Arg Glu Cys 
                85                  90                  95      


Glu Lys Lys Asp Lys Phe Gly Lys Met Arg Lys Tyr Pro Ile Phe Arg 
            100                 105                 110         


Cys Ser Tyr Ala Pro Ser Gly Lys Asn Met Lys Lys Val Met Glu Leu 
        115                 120                 125             


Tyr Val Arg Glu Arg Met Lys Asp Glu Trp Gln Ser Gln Ala Tyr Arg 
    130                 135                 140                 


Thr Ala Ala Ile Glu Ile Leu Leu Cys Ile Cys Asn Lys Asp Phe Ser 
145                 150                 155                 160 


Lys Gln Leu Ser Arg Val Asp Ala Arg Ile Phe Ala Asp Phe Tyr Asn 
                165                 170                 175     


Ala Ser Lys Ala Cys Pro Gln Pro Tyr Ile Gly Lys Ser Thr Gly Val 
            180                 185                 190         


Leu Glu Ala Ala Phe Thr Ser Val Met Lys Gln Met Ser Leu His Ala 
        195                 200                 205             


Lys Ala Asn Ala Ser Asn Lys Ile Trp Trp Leu Gln Asn Gln Leu Arg 
    210                 215                 220                 


Thr Ile Glu Leu Asn Lys Lys Ile Val Lys Ile Ser Asp Phe Lys Tyr 
225                 230                 235                 240 


Glu Tyr Ala Thr Glu Asp Arg Met Arg Ala Ile Leu Val Arg Met Arg 
                245                 250                 255     


Lys Ser Leu Lys Arg Gly Thr Asn Gly Asp Ile Ala Val Ala Leu Leu 
            260                 265                 270         


Gln Gly Ile Ala Gln Met Asn Gly Lys Thr Leu Ser Gly Val Leu Glu 
        275                 280                 285             


Glu Leu Ser Ala Asn Ser Glu Thr Lys Glu Gln Leu Ile Lys Phe Leu 
    290                 295                 300                 


Lys Ala Val His Glu Asp Tyr His Lys Thr Pro Ile Leu Lys Ala Ile 
305                 310                 315                 320 


Arg Asn Gln Asp Val Lys Val Gln Val His Glu Val Asp Pro Val Ser 
                325                 330                 335     


Pro Glu Gly Arg Ala Leu Asp Leu Ala Ser Ile Asn Val Ser Lys Gly 
            340                 345                 350         


Asn Glu Arg Lys Lys Tyr Lys Val Ala Leu Thr Gln Thr Leu Gly Asn 
        355                 360                 365             


Tyr Ala Lys Ser Pro Lys Asp Ala Thr Gln Thr Leu Lys Ala Ile Lys 
    370                 375                 380                 


Gly Val Leu Leu Asp Tyr Phe Met Trp Leu Asp Ser Asp Val Lys Ala 
385                 390                 395                 400 


Glu Phe Leu Glu Asp Asn Asn Leu Trp Lys Ile Pro Asn Arg Thr Glu 
                405                 410                 415     


Glu Tyr Phe Asp Asn Asn Phe Val Pro Ile Asp Asp Lys Lys Asp Asp 
            420                 425                 430         


Lys Ile Glu Ala Ile Glu Asp Phe Ala Ser Ile Trp Arg Gln Glu Arg 
        435                 440                 445             


Val Lys Asn Ser Arg Ile Lys Ala Arg Met Asn Tyr Val Asn Cys Gly 
    450                 455                 460                 


Lys Tyr Gln Gln Leu Ile Lys Gln Glu Thr Asp Asp Phe Arg Ile Cys 
465                 470                 475                 480 


Trp Ile Ser Tyr Ala Lys Asp Phe Val Glu Lys Asn Tyr Val Ser Lys 
                485                 490                 495     


Asn Arg Gln Phe Thr Gln Gly Asp Cys Phe Ser Thr Lys Met Leu Leu 
            500                 505                 510         


Glu Cys Trp Lys Glu Ile Ile Arg Phe Ile Cys Gly Lys Tyr Ile Asp 
        515                 520                 525             


Ile Gly Lys Ala Val Tyr His Phe Ala Met Pro Glu Thr Met Asn Ala 
    530                 535                 540                 


Arg Asp Ser Leu Ala Tyr Gly Val Leu Gly Glu Lys Tyr Lys Glu Gly 
545                 550                 555                 560 


Ile Ser Ser Phe Asp Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln 
                565                 570                 575     


Arg Asp Ile Ala Lys Ala Ala Val Ala Ala Ile His Ala Phe Ser Gly 
            580                 585                 590         


Ser Val Ile Asp Asp Lys Lys Pro Val Glu Asp Ile Leu Phe Ile Lys 
        595                 600                 605             


Asp Glu Glu Leu Gln Glu His Ala Lys Ala Asp Asp Val Ile Val Lys 
    610                 615                 620                 


Gln Ile Leu Arg Phe Tyr Gly Gly Phe Ser Ser Val Glu Gly Arg Glu 
625                 630                 635                 640 


Lys Leu Glu Gly Met Ala Leu Ala Lys Glu Val Leu Ser Gln Leu Lys 
                645                 650                 655     


Ala Ile Arg Asn Glu Asn Phe His Phe Thr Gln Gly Lys Arg Lys Asn 
            660                 665                 670         


Val Glu Glu Asn Ile Pro Leu Thr Lys Ala Leu Trp Glu Asn Glu Glu 
        675                 680                 685             


Lys Val Tyr Arg Gln Thr Val Lys Glu Thr Tyr Tyr Ser Asn Asn Val 
    690                 695                 700                 


Ser Met Phe Tyr Ser Gln Glu Val Ile Gln Lys Leu Val Ala Glu Leu 
705                 710                 715                 720 


Tyr Gln Asn Asn Asn Val Ala Glu Ala Gln Ile Pro Ala Phe Arg Thr 
                725                 730                 735     


Ile Trp Lys Arg Lys Asp Leu Pro Glu Tyr Ile Gly Ser Leu Asn Ile 
            740                 745                 750         


Ser Trp Asp Lys Thr Glu Pro Lys Gln Val Ile Tyr Glu Gly Ala Leu 
        755                 760                 765             


Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Lys Ser Gly 
    770                 775                 780                 


Glu Ala Lys Lys Leu Phe Phe Asp Ala Val Met Asp Asn Ala Thr Glu 
785                 790                 795                 800 


Met Glu Lys Ser Ser Asn Ala Asp Ser Arg Asn Gln Glu Lys Lys Ala 
                805                 810                 815     


Leu Ala Asn Ala Gly Lys Asn Phe Arg Asp Tyr Val Asn Gly Leu Asn 
            820                 825                 830         


Ala Ser Thr Leu Gly Glu Val Cys Gln Phe Ile Gln Asn Glu Tyr Asn 
        835                 840                 845             


Gln Gln Asn Arg Gly Lys Gln Glu Gln Glu Ile Tyr Lys His Phe Lys 
    850                 855                 860                 


Met Leu Leu Pro Ile Cys Met Arg Lys Ala Phe Gln Arg Tyr Ile Asp 
865                 870                 875                 880 


Glu Lys His Ser Phe Ile Lys Lys Pro Gly Glu Leu Pro Gln Thr Thr 
                885                 890                 895     


Glu Asp Tyr Leu Glu Asn Val Lys Val Ala Cys Pro Glu Lys Lys Ile 
            900                 905                 910         


Lys Leu Gly Arg Trp Phe Thr Phe Ala His Phe Ile His Pro Arg Glu 
        915                 920                 925             


Leu Asn Phe Leu Ile Gly Asp Phe Lys Asn Tyr Ile Gln Tyr Arg Glu 
    930                 935                 940                 


Asp Val Leu Arg Arg Ser Glu His Ala Gly Gln Phe Ser Asp Thr Thr 
945                 950                 955                 960 


Glu Arg Asp Gly Glu Lys Ala Val Val Asp His Ala Val Gln Lys Ala 
                965                 970                 975     


Lys Asp Ile Leu Gly Val Leu Glu Phe Val Arg His Ile Ser Gly Arg 
            980                 985                 990         


Val Ser Asn Glu Phe Thr Asp Tyr  Tyr Ala Asp Arg Ala  Glu Tyr Asp 
        995                 1000                 1005             


Glu Tyr  Met Ala Lys Tyr Phe  Glu Pro Asp Val Gln  Ile Glu Gln 
    1010                 1015                 1020             


Tyr Asp  Leu Tyr Gly Asp Ala  Lys Asn Ala Lys Val  Ile Arg Asn 
    1025                 1030                 1035             


Ile Glu  Leu Ala Arg Met Tyr  Ala Gly Asp Ser Leu  Met Ser Ala 
    1040                 1045                 1050             


Ser Tyr  Arg Lys Ile Thr Lys  Lys Glu Ile Glu Thr  Tyr Tyr Ala 
    1055                 1060                 1065             


Lys Lys  Asp Glu Ile Ala Gln  Leu Gln Ser Gln Gly  Ile Cys Asn 
    1070                 1075                 1080             


Ser Lys  Lys Glu Gln Glu Asp  Ile Val Ala Phe Gln  Lys Leu Lys 
    1085                 1090                 1095             


Asn Arg  Ile Thr Leu Asn Glu  Val Thr Asp Leu Trp  Ser Leu Val 
    1100                 1105                 1110             


Asn Glu  Leu Leu Gly Asn Leu  Val Ser Leu Ala Tyr  Leu Arg Glu 
    1115                 1120                 1125             


Arg Asp  Glu Met Tyr Leu Phe  Leu Gly Phe Tyr Tyr  Met Ala Leu 
    1130                 1135                 1140             


Arg His  Pro Glu Gly Trp Thr  Asn Glu Ile Met Asn  Ser Val Ser 
    1145                 1150                 1155             


Asn Glu  Lys Tyr Ala Val Lys  Glu Gly Leu Val Leu  Tyr Gln Thr 
    1160                 1165                 1170             


Val Ala  Val Phe Asp Phe Gly  Thr Lys Leu Leu Phe  Gln Asn Asp 
    1175                 1180                 1185             


Asn Gln  Lys Trp Glu Glu Thr  Thr Gly Tyr Lys Trp  Gln His Phe 
    1190                 1195                 1200             


Ile Asp  Asn His Lys Glu Ser  Tyr Ala Cys Ile Leu  Pro Leu Phe 
    1205                 1210                 1215             


Glu Ile  Ala Lys Cys Glu Thr  Glu Ala Arg Ala Val  Arg Asn Tyr 
    1220                 1225                 1230             


Val Asp  His Phe Lys Tyr Tyr  Ser Asn Glu Asp Arg  Ser Ile Leu 
    1235                 1240                 1245             


Glu Leu  Tyr Gly Lys Phe Tyr  Thr His Leu Phe Gly  Tyr Ser Thr 
    1250                 1255                 1260             


Arg Leu  Arg Lys Ser Val Leu  Gln Ile Leu Ala Gln  Thr Leu Glu 
    1265                 1270                 1275             


Lys His  Gly Ile Ser Ala Gly  Ile Gln Phe Asp Gly  Thr Thr Val 
    1280                 1285                 1290             


Lys Ala  Thr Arg Cys Asp Met  Lys Ser Val Glu Phe  Thr Tyr Lys 
    1295                 1300                 1305             


Tyr Glu  Glu Lys Leu Asn Glu  Gln Lys Thr Val Leu  Arg Thr Ile 
    1310                 1315                 1320             


Ser Leu  Pro Ala Lys Ser Glu  Gly Phe Ile Thr Ala  Val Cys Glu 
    1325                 1330                 1335             


Met Leu  Lys Gln Lys Lys Gly  Asp His Thr Glu Asn  Thr Leu Cys 
    1340                 1345                 1350             


<210>  461
<211>  1353
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  461

Met Lys Val Thr Lys Ala Glu Lys Leu Arg Val Ala Val Ser Arg Lys 
1               5                   10                  15      


Leu Asn Asn Glu Asp Lys Arg Ala Val Leu Tyr Lys Thr Pro Asn Pro 
            20                  25                  30          


Gly Gln Thr Cys Gly Thr Val Lys Lys Gln Leu Ala Asn Arg Val Glu 
        35                  40                  45              


Arg Ala Asn Lys Leu Tyr Gly Val Phe Phe Arg Ser Asp Val Pro Glu 
    50                  55                  60                  


Thr Leu Gln Tyr His Phe Glu Glu Leu Val Thr Tyr Ala Ala Gln Ser 
65                  70                  75                  80  


Thr Ser Pro Asn Glu Phe Arg Gln Lys Ala Ser Gln Tyr Arg Glu Cys 
                85                  90                  95      


Glu Lys Lys Asp Lys Phe Gly Lys Met Arg Lys Tyr Pro Ile Phe Arg 
            100                 105                 110         


Cys Ser Tyr Ala Pro Ser Gly Lys Asn Met Lys Lys Val Met Glu Leu 
        115                 120                 125             


Tyr Val Arg Glu Arg Met Lys Asp Glu Trp Gln Ser Gln Ala Tyr Arg 
    130                 135                 140                 


Thr Ala Ala Ile Glu Ile Leu Leu Cys Ile Cys Asn Lys Asp Phe Ser 
145                 150                 155                 160 


Lys Gln Leu Ser Arg Val Asp Ala Arg Ile Phe Ala Asp Phe Tyr Asn 
                165                 170                 175     


Ala Ser Lys Ala Cys Pro Gln Pro Tyr Ile Gly Lys Ser Thr Gly Val 
            180                 185                 190         


Leu Glu Ala Ala Phe Thr Ser Val Met Lys Gln Met Ser Leu His Ala 
        195                 200                 205             


Lys Ala Asn Ala Ser Asn Lys Ile Trp Trp Leu Gln Asn Gln Leu Arg 
    210                 215                 220                 


Thr Ile Glu Leu Asn Lys Lys Ile Val Lys Ile Ser Asp Phe Lys Tyr 
225                 230                 235                 240 


Glu Tyr Ala Thr Glu Asp Arg Met Arg Ala Ile Leu Val Arg Met Arg 
                245                 250                 255     


Lys Ser Leu Lys Arg Gly Thr Asn Gly Asp Ile Ala Val Ala Leu Leu 
            260                 265                 270         


Gln Gly Ile Ala Gln Met Asn Gly Lys Thr Leu Ser Gly Val Leu Glu 
        275                 280                 285             


Glu Leu Ser Ala Asn Ser Glu Thr Lys Glu Gln Leu Ile Lys Phe Leu 
    290                 295                 300                 


Lys Ala Val His Glu Asp Tyr His Lys Thr Pro Ile Leu Lys Ala Ile 
305                 310                 315                 320 


Arg Asn Gln Asp Val Lys Val Gln Val His Glu Val Asp Pro Val Ser 
                325                 330                 335     


Pro Glu Gly Arg Ala Leu Asp Leu Ala Ser Ile Asn Val Ser Lys Gly 
            340                 345                 350         


Asn Glu Arg Lys Lys Tyr Lys Val Ala Leu Thr Gln Thr Leu Gly Asn 
        355                 360                 365             


Tyr Ala Lys Ser Pro Lys Asp Ala Thr Gln Thr Leu Lys Ala Ile Lys 
    370                 375                 380                 


Gly Val Leu Leu Asp Tyr Phe Met Trp Leu Asp Ser Asp Val Lys Ala 
385                 390                 395                 400 


Glu Phe Leu Glu Asp Asn Asn Leu Trp Lys Ile Pro Asn Arg Thr Glu 
                405                 410                 415     


Glu Tyr Phe Asp Asn Asn Phe Val Pro Ile Asp Asp Lys Lys Asp Asp 
            420                 425                 430         


Lys Ile Glu Ala Ile Glu Asp Phe Ala Ser Ile Trp Arg Gln Glu Arg 
        435                 440                 445             


Val Lys Asn Ser Arg Ile Lys Ala Arg Met Asn Tyr Val Asn Cys Gly 
    450                 455                 460                 


Lys Tyr Gln Gln Leu Ile Lys Gln Glu Thr Asp Asp Phe Arg Ile Cys 
465                 470                 475                 480 


Trp Ile Ser Tyr Ala Lys Asp Phe Val Glu Lys Asn Tyr Val Ser Lys 
                485                 490                 495     


Asn Arg Gln Phe Thr Gln Gly Asp Cys Phe Ser Thr Lys Met Leu Leu 
            500                 505                 510         


Glu Cys Trp Lys Glu Ile Ile Arg Phe Ile Cys Gly Lys Tyr Ile Asp 
        515                 520                 525             


Ile Gly Lys Ala Val Tyr His Phe Ala Met Pro Glu Thr Met Asn Ala 
    530                 535                 540                 


Arg Asp Ser Leu Ala Tyr Gly Val Leu Gly Glu Lys Tyr Lys Glu Gly 
545                 550                 555                 560 


Ile Ser Ser Phe Asp Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln 
                565                 570                 575     


Arg Asp Ile Ala Lys Ala Ala Val Ala Ala Ile His Ala Phe Ser Gly 
            580                 585                 590         


Ser Val Ile Asp Asp Lys Lys Pro Val Glu Asp Ile Leu Phe Ile Lys 
        595                 600                 605             


Asp Glu Glu Leu Gln Glu His Ala Lys Ala Asp Asp Val Ile Val Lys 
    610                 615                 620                 


Gln Ile Leu Arg Phe Tyr Gly Gly Phe Ser Ser Val Glu Gly Arg Glu 
625                 630                 635                 640 


Lys Leu Glu Gly Met Ala Leu Ala Lys Glu Val Leu Ser Gln Leu Lys 
                645                 650                 655     


Ala Ile Arg Asn Glu Asn Phe His Phe Thr Gln Gly Lys Arg Lys Asn 
            660                 665                 670         


Val Glu Glu Asn Ile Pro Leu Thr Lys Ala Leu Trp Glu Asn Glu Glu 
        675                 680                 685             


Lys Val Tyr Arg Gln Thr Val Lys Glu Thr Tyr Tyr Ser Asn Asn Val 
    690                 695                 700                 


Ser Met Phe Tyr Ser Gln Glu Val Ile Gln Lys Leu Val Ala Glu Leu 
705                 710                 715                 720 


Tyr Gln Asn Asn Asn Val Ala Glu Ala Gln Ile Pro Ala Phe Arg Thr 
                725                 730                 735     


Ile Trp Lys Arg Lys Asp Leu Pro Glu Tyr Ile Gly Ser Leu Asn Ile 
            740                 745                 750         


Ser Trp Asp Lys Thr Glu Pro Lys Gln Val Ile Tyr Glu Gly Ala Leu 
        755                 760                 765             


Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Lys Ser Gly 
    770                 775                 780                 


Glu Ala Lys Lys Leu Phe Phe Asp Ala Val Met Asp Asn Ala Thr Glu 
785                 790                 795                 800 


Met Glu Lys Ser Ser Asn Ala Asp Ser Arg Asn Gln Glu Lys Lys Ala 
                805                 810                 815     


Leu Ala Asn Ala Gly Lys Asn Phe Arg Asp Tyr Val Asn Gly Leu Asn 
            820                 825                 830         


Ala Ser Thr Leu Gly Glu Val Cys Gln Phe Ile Gln Asn Glu Tyr Asn 
        835                 840                 845             


Gln Gln Asn Arg Gly Lys Gln Glu Gln Glu Ile Tyr Lys His Phe Lys 
    850                 855                 860                 


Met Leu Leu Pro Ile Cys Met Arg Lys Ala Phe Gln Arg Tyr Ile Asp 
865                 870                 875                 880 


Glu Lys His Ser Phe Ile Lys Lys Pro Gly Glu Leu Pro Gln Thr Thr 
                885                 890                 895     


Glu Asp Tyr Leu Glu Asn Val Lys Val Ala Cys Pro Glu Lys Lys Ile 
            900                 905                 910         


Lys Leu Gly Arg Trp Phe Thr Phe Ala His Phe Ile His Pro Arg Glu 
        915                 920                 925             


Leu Asn Phe Leu Ile Gly Asp Phe Lys Asn Tyr Ile Gln Tyr Arg Glu 
    930                 935                 940                 


Asp Val Leu Arg Arg Ser Glu His Ala Gly Gln Phe Ser Asp Thr Thr 
945                 950                 955                 960 


Glu Arg Asp Gly Glu Lys Ala Val Val Asp His Ala Val Gln Lys Ala 
                965                 970                 975     


Lys Asp Ile Leu Gly Val Leu Glu Phe Val Arg His Ile Ser Gly Arg 
            980                 985                 990         


Val Ser Asn Glu Phe Thr Asp Tyr  Tyr Ala Asp Arg Ala  Glu Tyr Asp 
        995                 1000                 1005             


Glu Tyr  Met Ala Lys Tyr Phe  Glu Pro Asp Val Gln  Ile Glu Gln 
    1010                 1015                 1020             


Tyr Asp  Leu Tyr Gly Asp Ala  Lys Asn Ala Lys Val  Ile Arg Asn 
    1025                 1030                 1035             


Ile Glu  Leu Ala Arg Met Tyr  Ala Gly Asp Ser Leu  Met Ser Ala 
    1040                 1045                 1050             


Ser Tyr  Arg Lys Ile Thr Lys  Lys Glu Ile Glu Thr  Tyr Tyr Ala 
    1055                 1060                 1065             


Lys Lys  Asp Glu Ile Ala Gln  Leu Gln Ser Gln Gly  Ile Cys Asn 
    1070                 1075                 1080             


Ser Lys  Lys Glu Gln Glu Asp  Ile Val Ala Phe Gln  Lys Leu Lys 
    1085                 1090                 1095             


Asn Arg  Ile Thr Leu Asn Glu  Val Thr Asp Leu Trp  Ser Leu Val 
    1100                 1105                 1110             


Asn Glu  Leu Leu Gly Asn Leu  Val Ser Leu Ala Tyr  Leu Arg Glu 
    1115                 1120                 1125             


Arg Asp  Glu Met Tyr Leu Phe  Leu Gly Phe Tyr Tyr  Met Ala Leu 
    1130                 1135                 1140             


Arg His  Pro Glu Gly Trp Thr  Asn Glu Ile Met Asn  Ser Val Ser 
    1145                 1150                 1155             


Asn Glu  Lys Tyr Ala Val Lys  Glu Gly Leu Val Leu  Tyr Gln Thr 
    1160                 1165                 1170             


Val Ala  Val Phe Asp Phe Gly  Thr Lys Leu Leu Phe  Gln Asn Asp 
    1175                 1180                 1185             


Asn Gln  Lys Trp Glu Glu Thr  Thr Gly Tyr Lys Trp  Gln His Phe 
    1190                 1195                 1200             


Ile Asp  Asn His Lys Glu Ser  Tyr Ala Cys Ile Leu  Pro Leu Phe 
    1205                 1210                 1215             


Glu Ile  Ala Lys Cys Glu Thr  Glu Ala Arg Ala Val  Arg Asn Tyr 
    1220                 1225                 1230             


Val Asp  His Phe Lys Tyr Tyr  Ser Asn Glu Asp Arg  Ser Ile Leu 
    1235                 1240                 1245             


Glu Leu  Tyr Gly Lys Phe Tyr  Thr His Leu Phe Gly  Tyr Ser Thr 
    1250                 1255                 1260             


Arg Leu  Arg Lys Ser Val Leu  Gln Ile Leu Ala Gln  Thr Leu Glu 
    1265                 1270                 1275             


Lys His  Gly Ile Ser Ala Gly  Ile Gln Phe Asp Gly  Thr Thr Val 
    1280                 1285                 1290             


Lys Ala  Thr Arg Cys Asp Met  Lys Ser Val Glu Phe  Thr Tyr Lys 
    1295                 1300                 1305             


Tyr Glu  Glu Lys Leu Asn Glu  Gln Lys Thr Val Leu  Arg Thr Ile 
    1310                 1315                 1320             


Ser Leu  Pro Ala Lys Ser Glu  Gly Phe Ile Thr Ala  Val Cys Glu 
    1325                 1330                 1335             


Met Leu  Lys Gln Lys Lys Gly  Asp His Thr Glu Asn  Thr Leu Cys 
    1340                 1345                 1350             


<210>  462
<211>  1284
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  462

Met Arg Met Lys Ile Ser Lys Val Asp His Val Lys Ser Gly Ile Asp 
1               5                   10                  15      


Gln Lys Leu Ser Asn Gln Arg Gly Met Leu Tyr Lys Gln Pro Gln Lys 
            20                  25                  30          


Lys Tyr Glu Gly Lys Gln Leu Glu Glu His Val Arg Asn Leu Asn Arg 
        35                  40                  45              


Lys Ala Lys Ala Leu Tyr Gln Val Phe Pro Ala Ser Gly Asn Pro Lys 
    50                  55                  60                  


Thr Glu Lys Glu Leu Gln Ile Ile Asn Ser Phe Ile Lys Asn Ile Leu 
65                  70                  75                  80  


Ile Arg Leu Asp Ser Gly Lys Thr Ser Glu Glu Ile Val Gly Tyr Ile 
                85                  90                  95      


Asn Thr Tyr Ser Val Ala Gly Gln Ile Ser Gly Asp His Ile Gln Glu 
            100                 105                 110         


Leu Val Asp Gln His Leu Lys Glu Ser Leu Arg Lys Tyr Thr Cys Val 
        115                 120                 125             


Asp Asp Lys Arg Ile Tyr Val Pro Asp Ile Ile Val Ala Leu Leu Lys 
    130                 135                 140                 


Ser Lys Phe Asn Ser Glu Thr Leu Gln Tyr Asp Asn Ser Glu Leu Lys 
145                 150                 155                 160 


Ile Leu Ile Asp Phe Ile Arg Glu Asp Tyr Leu Lys Glu Lys Gln Ile 
                165                 170                 175     


Lys Gln Ile Val His Ser Ile Glu Asn Asn Ser Thr Pro Leu Arg Ile 
            180                 185                 190         


Ala Glu Ile Asn Gly Gln Lys Arg Leu Ile Pro Ala Asn Ala Asp Asn 
        195                 200                 205             


Pro Lys Lys Ser Tyr Ile Phe Glu Phe Leu Lys Glu Tyr Ala Gln Ser 
    210                 215                 220                 


Asp Pro Lys Gly Gln Glu Ser Leu Leu Gln His Met Arg Tyr Leu Ile 
225                 230                 235                 240 


Leu Leu Tyr Leu Tyr Gly Ser Asp Lys Ile Thr Asp Asp Tyr Cys Glu 
                245                 250                 255     


Glu Ile Gly Ala Trp Asn Phe Gly Ser Ile Val Met Asp Asn Glu Gln 
            260                 265                 270         


Leu Phe Ser Glu Glu Ala Ser Met Leu Ile Gln Asp Arg Ile Tyr Val 
        275                 280                 285             


Asn Gln Gln Ile Gln Glu Gly Arg Gln Ser Lys Asp Thr Ala Lys Val 
    290                 295                 300                 


Lys Lys Asn Lys Ser Lys Tyr Arg Met Leu Gly Asp Lys Ile Glu His 
305                 310                 315                 320 


Ser Ile Asn Glu Ser Val Val Lys His Tyr Gln Glu Ala Cys Lys Ala 
                325                 330                 335     


Val Glu Glu Lys Asp Ile Pro Trp Ile Lys Tyr Ile Ser Asp His Val 
            340                 345                 350         


Met Ser Val Tyr Ser Ser Lys Asn Arg Val Asp Leu Asp Lys Leu Ser 
        355                 360                 365             


Leu Pro Tyr Leu Ala Lys Asn Thr Trp Asn Thr Trp Ile Ser Phe Ile 
    370                 375                 380                 


Ala Met Lys Tyr Val Asp Met Gly Lys Gly Val Tyr His Phe Ala Met 
385                 390                 395                 400 


Ser Asp Val Asp Lys Val Gly Lys Gln Asp Asn Leu Ile Ile Gly Gln 
                405                 410                 415     


Ile Asp Pro Lys Phe Ala Asp Gly Ile Ser Ser Phe Asp Tyr Glu Arg 
            420                 425                 430         


Ile Lys Ala Glu Asp Asp Leu His Arg Ser Met Ser Gly Tyr Ile Ala 
        435                 440                 445             


Phe Ala Val Asn Asn Phe Ser Arg Ala Ile Cys Ser Asp Glu Phe Arg 
    450                 455                 460                 


Lys Lys Asp Lys Lys Glu Asp Val Leu Thr Val Gly Leu Asp Glu Ile 
465                 470                 475                 480 


Pro Leu Asp Asp Asn Val Lys Arg Lys Leu Leu Gln Tyr Phe Gly Gly 
                485                 490                 495     


Ala Ser Asn Trp Asp Asp Ser Ile Met Asp Ile Ile Asp Asp Lys Asp 
            500                 505                 510         


Leu Ala Ala Cys Ile Lys Glu Asn Leu Tyr Val Ala Arg Asn Val Asn 
        515                 520                 525             


Phe His Phe Ala Gly Ser Glu Lys Val Gln Lys Lys Gln Asp Asp Ile 
    530                 535                 540                 


Leu Glu Glu Ile Val Arg Lys Glu Thr Gly Asp Ile Gly Lys His Tyr 
545                 550                 555                 560 


Arg Lys Val Phe Tyr Ser Asn Asn Val Ala Ala Phe Tyr Arg Asp Glu 
                565                 570                 575     


Asp Ile Ile Lys Leu Met Asn His Leu Tyr Gln Lys Glu Lys Pro Tyr 
            580                 585                 590         


Gln Ala Gln Ile Pro Ser Tyr Asn Lys Val Ile Ser Lys Thr Tyr Leu 
        595                 600                 605             


Pro Asp Leu Ile Phe Met Leu Leu Lys Gly Lys Asn Arg Thr Lys Ile 
    610                 615                 620                 


Ser Asp Pro Ser Ile Met Asn Met Phe Arg Gly Thr Phe Tyr Phe Leu 
625                 630                 635                 640 


Leu Lys Glu Ile Tyr Tyr Asn Asp Phe Leu Gln Ala Ser Asn Leu Lys 
                645                 650                 655     


Glu Leu Phe Arg Glu Gly Leu Lys Asn Asn Val Lys Asp Lys Lys Ser 
            660                 665                 670         


Glu Lys Ala Tyr Gln Asn Phe Met Gln Arg Phe Glu Glu Leu Glu Asn 
        675                 680                 685             


Met Gly Met Asp Phe Gly Glu Ile Cys Gln Gln Ile Met Thr Asp Tyr 
    690                 695                 700                 


Glu Gln Gln Asn Lys Gln Lys Lys Lys Thr Ala Thr Ala Val Val Ser 
705                 710                 715                 720 


Glu Lys Asp Lys Lys Ile Arg Thr Leu Asp Asn Asp Thr Gln Lys Tyr 
                725                 730                 735     


Lys His Phe Arg Thr Leu Leu Tyr Val Gly Leu Arg Glu Ala Phe Ile 
            740                 745                 750         


Ile Tyr Leu Lys Asp Glu Lys Asn Lys Glu Trp Tyr Glu Phe Leu Arg 
        755                 760                 765             


Glu Pro Val Lys Arg Glu Gln Pro Glu Glu Lys Glu Phe Val Asn Lys 
    770                 775                 780                 


Trp Lys Leu Asn Gln Tyr Ser Asp Cys Ser Glu Leu Ile Leu Lys Asp 
785                 790                 795                 800 


Pro Leu Ala Ala Ala Trp Tyr Val Ala Ala His Phe Ile Asn Gln Ala 
                805                 810                 815     


Gln Leu Asn His Leu Ile Gly Asp Ile Lys Asn Tyr Ile Gln Phe Ile 
            820                 825                 830         


Ser Asp Ile Asp Arg Arg Ala Lys Ser Thr Gly Asn Pro Val Ser Glu 
        835                 840                 845             


Ser Thr Glu Ile Gln Ile Asp Arg Tyr Arg Gln Ile Leu Arg Val Leu 
    850                 855                 860                 


Glu Phe Ala Lys Phe Phe Cys Gly Gln Ile Thr Asn Val Leu Thr Asp 
865                 870                 875                 880 


Tyr Tyr Glu Asp Glu Asn Asp Phe Ser Thr His Val Gly His Tyr Val 
                885                 890                 895     


Lys Phe Glu Lys Lys Asn Met Glu Pro Ala His Ala Leu Gln Ala Phe 
            900                 905                 910         


Ser Asn Ser Leu Tyr Ala Cys Gly Lys Glu Lys Lys Lys Ala Gly Phe 
        915                 920                 925             


Tyr Tyr Asp Gly Met Asn Pro Ile Val Asn Arg Asn Ile Thr Leu Ala 
    930                 935                 940                 


Ala Met Tyr Gly Asn Lys Lys Leu Leu Glu Asn Ala Met Ile Pro Val 
945                 950                 955                 960 


Thr Glu Gln Asp Ile Arg Lys Tyr Tyr Ser Leu Met Ala Glu Leu Asp 
                965                 970                 975     


Ser Thr Leu Lys Asn Gly Ala Val Cys Lys Ser Glu Asp Glu Gln Lys 
            980                 985                 990         


Asn Leu Arg His Phe Gln Asn Leu  Lys Asn Arg Ile Glu  Leu Val Asp 
        995                 1000                 1005             


Val Leu  Thr Leu Ser Glu Leu  Leu Asn Asp Leu Val  Ala Gln Leu 
    1010                 1015                 1020             


Ile Gly  Trp Ala Tyr Ile Arg  Glu Arg Asp Met Met  Tyr Leu Gln 
    1025                 1030                 1035             


Leu Gly  Leu His Tyr Ile Lys  Leu Tyr Phe Thr Asp  Ser Val Ser 
    1040                 1045                 1050             


Glu Asp  Ser Tyr Leu Arg Thr  Leu Asp Leu Glu Glu  Gly Ser Ile 
    1055                 1060                 1065             


Ala Asp  Gly Ala Val Leu Tyr  Gln Ile Ala Ser Leu  Tyr Ser Phe 
    1070                 1075                 1080             


Asn Leu  Pro Met Tyr Val Lys  Pro Asn Glu Ser Ser  Val Tyr Cys 
    1085                 1090                 1095             


Lys Lys  His Ala Asn Ser Val  Gly Ala Lys Phe Asp  Ile Phe Glu 
    1100                 1105                 1110             


Lys Lys  Tyr Cys Asn Arg Asp  Gly Thr Val Ile Glu  Asn Gly Leu 
    1115                 1120                 1125             


Cys Leu  Phe Glu Asn Ile Lys  Leu His Gly Asp Leu  Ala Glu Phe 
    1130                 1135                 1140             


Arg Asp  Tyr Leu Ala His Phe  Lys Tyr Phe Ala Lys  Leu Asp Lys 
    1145                 1150                 1155             


Ser Ile  Leu Glu Leu Tyr Ser  Lys Val Tyr Asp Ser  Phe Phe Ser 
    1160                 1165                 1170             


Tyr Asn  Ile Lys Leu Lys Lys  Ser Val Ser Tyr Val  Phe Thr Asn 
    1175                 1180                 1185             


Ile Leu  Leu Ser Tyr Phe Ile  Asn Ala Lys Leu Ser  Phe Ser Leu 
    1190                 1195                 1200             


Cys Gly  Ile Ser Asp Tyr Lys  Pro Ser Arg Asn Lys  Thr Val Gln 
    1205                 1210                 1215             


Arg Arg  Ser Ala Asn Ile Ser  Val Glu Ser Val Gln  Thr Asp Tyr 
    1220                 1225                 1230             


Phe Thr  Tyr Lys Leu Arg Ser  Ile Val Lys Asn Lys  Asn Gly Val 
    1235                 1240                 1245             


Glu Ser  Ile Glu Asn Asp Asn  Arg Arg Cys Glu Val  Val Asn Ile 
    1250                 1255                 1260             


Ala Ala  Arg Asp Lys Glu Phe  Val Asp Glu Val Cys  Lys Val Ile 
    1265                 1270                 1275             


Lys Tyr  Asn Ser Asp Lys 
    1280                 


<210>  463
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  463

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Gly Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asp 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  464
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  464

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Asp Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Cys Gln Arg Ile Ile Asn Asp Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His 
            180                 185                 190         


Glu Arg Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Arg Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Ile His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Ile  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Arg Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  465
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  465

Met Lys Ile Ser Lys Glu Gly His Lys Arg Met Ser Val Thr Leu Lys 
1               5                   10                  15      


Asn Glu Glu Val Gln Lys Asn Ala Ala Asp Lys Ala Glu Gly Gln Ile 
            20                  25                  30          


Leu Pro Leu Glu Lys Gly Gln Lys Leu Lys Thr Tyr Ile Gln Lys Arg 
        35                  40                  45              


Val Asp Ser Ser Lys Arg Leu Tyr Lys Val Leu Gly Pro Ser Ala Val 
    50                  55                  60                  


Ser Lys Leu Asn Val Ala Lys Ser Glu Ala Val Leu Lys Cys Phe Asn 
65                  70                  75                  80  


Asp Phe Met Lys Asn Ile Ile Asp Asn Asn Val Arg Val Lys Pro Ala 
                85                  90                  95      


Asp Lys Arg Asp Arg Thr Ala Val Asp Tyr Ile Gln Asn Arg Gly Phe 
            100                 105                 110         


Ser Ile Glu Val Arg Asp Gly Thr Lys Glu Asp Lys Ser Asn Glu Asn 
        115                 120                 125             


Arg Gly Lys Lys Lys Glu Gln Lys Glu Ile Lys Lys Pro Leu Ser Asp 
    130                 135                 140                 


Val Tyr Ile Asp Val Asp Glu Ala Phe Val His Glu Leu Thr Arg Leu 
145                 150                 155                 160 


His Leu Arg Gly Thr Leu Lys Lys Lys Ala Lys Ile Glu Lys Asp Gly 
                165                 170                 175     


Thr Gln Val Asp Ile Tyr Ile Pro Asp Ile Ile Glu Lys Leu Val Phe 
            180                 185                 190         


Ala Thr Thr His Gly Ser Gln Phe Asp Ser Leu Ile Ser Gln Ile Gly 
        195                 200                 205             


Glu Ala Glu Leu Thr Ala Cys Ile His Ile Ile Phe Met Asp Tyr Thr 
    210                 215                 220                 


Lys Glu Glu Gln Ile Lys Lys Ile Ala Lys Ser Ile Glu Asn Gln Asp 
225                 230                 235                 240 


Val Lys Val Gln Val Leu Gly Lys Gly Lys Asp Ala Arg Leu Gln Leu 
                245                 250                 255     


Ala Ser Ala Asp Asn Glu Lys Lys Lys Tyr Ile Phe Leu Phe Leu Glu 
            260                 265                 270         


Lys Phe Ala Cys Ala Ala Ser Glu Glu Glu Arg Asp Asn Leu Leu Arg 
        275                 280                 285             


Glu Phe Arg Glu Leu Ile Val Leu Phe Tyr Cys Gly Thr Val Ser Tyr 
    290                 295                 300                 


Glu Glu Ile Lys Glu Arg Lys Thr Arg Ile Pro Val Trp Asp Phe Ser 
305                 310                 315                 320 


Phe Leu Ser Lys Met Val Ser Asp Val Pro Leu Ser Phe Ser Gln Glu 
                325                 330                 335     


Cys Ser Glu Lys Leu Ala Glu Arg Glu Leu Leu Lys Ala Glu Thr Asp 
            340                 345                 350         


Leu Glu Arg Arg Lys Glu Asn Lys Leu Lys Ile Arg Asp Ile Asn Thr 
        355                 360                 365             


Glu Val Lys Arg Asn Leu Glu Arg Ile Val Ala Gln Arg Tyr Gln Glu 
    370                 375                 380                 


Gly Ile Lys Ile Leu Gly Asp Val Ser Gly Glu Glu Tyr Lys Glu Lys 
385                 390                 395                 400 


Arg Phe Trp Leu Glu Tyr Ile Glu Asn Asp Ala Glu Lys Val Leu Cys 
                405                 410                 415     


Ser Lys Lys Thr Leu Ser Glu Asn Lys Leu Asp Val Leu Trp Leu Cys 
            420                 425                 430         


Glu Asn Thr Trp Arg Ser Phe Leu Ser Phe Ile Cys Ser Lys Ala Val 
        435                 440                 445             


Asp Met Gly Lys Ala Val Tyr His Phe Ala Met Pro Asp Leu Glu Lys 
    450                 455                 460                 


Ile Glu Ser Gly Lys Pro Val Arg Ala Gly Glu Ile Lys Pro Gln Phe 
465                 470                 475                 480 


Arg Lys Gly Ile Thr Ser Phe Asp Tyr Glu Lys Ile Lys Ala Glu Glu 
                485                 490                 495     


Asn Leu Glu Arg Ser Phe Met Thr Ala Ile Ser Phe Ala Leu Asn Asn 
            500                 505                 510         


Phe Ser Ser Ala Val Cys Pro Pro Glu Thr Tyr Glu Lys Glu Gly Lys 
        515                 520                 525             


Glu Asp Ile Leu Phe Met Gly Asp Asp Ala Leu Gln Lys Glu Met Tyr 
    530                 535                 540                 


Pro Asn Ala Ser Trp Arg Ile Leu Gln Tyr Phe Gly Gly Ala Ser Gln 
545                 550                 555                 560 


Trp Lys Asp Ser Arg Phe Glu Glu Val Ser Asp Ser Gln Lys Ala Val 
                565                 570                 575     


Leu Ile Asn Glu Ser Phe Val Pro Glu Ile Arg Arg Ala Met Gln Leu 
            580                 585                 590         


Ile Arg Asn Ser Ala Phe His Tyr Ala Ala Ser Ala Ala Gln Ser Thr 
        595                 600                 605             


Leu Asp Ser Thr Ser Tyr Leu Val Glu Ile Phe Glu Arg Glu Lys Lys 
    610                 615                 620                 


Leu Ile Gly Ser Lys Tyr Arg Lys Lys Tyr Val Ser Asn Asn Val Pro 
625                 630                 635                 640 


Val Phe Tyr Lys Val Glu Asp Ile Asp His Leu Met Lys Ser Leu Tyr 
                645                 650                 655     


Gly Ser Gln Lys Val Leu Glu Ser Gln Ile Pro Ser Phe Arg Asn Val 
            660                 665                 670         


Ile Ser Arg Lys Ser Leu Ser Glu Leu Ile Asn Gln Tyr Phe Ile Ile 
        675                 680                 685             


Asn Gly Thr Pro Tyr Arg Lys Met Lys Asn Asp Val Ala Thr Ser Glu 
    690                 695                 700                 


Lys Phe His Ala Ala Leu Tyr Phe Val Leu Lys Glu Ile Tyr Tyr Asn 
705                 710                 715                 720 


Gly Phe Leu Gln Glu Asp Asn Leu Met Glu Arg Phe Met Asp Ser Phe 
                725                 730                 735     


His Asp Glu Leu Lys Glu Val Arg Asp Asn Thr Ser Lys Ala Ser Ala 
            740                 745                 750         


Lys Lys Val Lys Ala Met Glu Asn Phe Glu Glu Arg Ile Lys Glu Leu 
        755                 760                 765             


Arg Lys Gly Asn Lys Ser Leu Ser Phe Gly Gly Val Cys Gln Ala Ile 
    770                 775                 780                 


Met Thr Asp Tyr Asn Leu Gln Asn Asn Gln Lys Lys Val Arg Leu Asn 
785                 790                 795                 800 


Gly Lys Asp Asn Leu Pro Asp Glu Lys Tyr Lys His Phe Lys Met Leu 
                805                 810                 815     


Leu Leu Val Cys Leu Arg Arg Thr Phe Val Asp Tyr Leu Gln Lys Asp 
            820                 825                 830         


Val Glu Gly Glu Arg Phe Gly Cys Lys Phe Leu Lys Glu Pro Arg Leu 
        835                 840                 845             


Lys Glu Lys Ile Tyr Asp Asn Leu Thr Glu Glu Gln Phe Cys Asn Gly 
    850                 855                 860                 


Trp Gln Thr Asp Arg Tyr Asn Asn Leu Met Lys Gly Asp Ser Ser Tyr 
865                 870                 875                 880 


Asp Ser Trp Leu Ile Ser Trp Phe Ile Met Ala His Phe Met Thr Pro 
                885                 890                 895     


Lys His Leu Asn His Leu Arg Gly Glu Ile Lys Ser Tyr Leu Ser Tyr 
            900                 905                 910         


Val Gln Asn Ile Glu Arg Arg Arg Trp Asn Ala Thr Gly Ile Gln Ile 
        915                 920                 925             


Glu Asp Glu Lys Glu Lys Arg Lys Lys Tyr Glu Gln Val Leu Glu Val 
    930                 935                 940                 


Leu Glu Leu Ala Ala Glu Tyr Cys Gly Gln Val Ser Lys Glu Arg Thr 
945                 950                 955                 960 


Asp Tyr Tyr Glu Ser Glu Glu Glu Tyr Ala Arg His Ile Ser Arg Tyr 
                965                 970                 975     


Ile Ala Phe Asp Asp Ser Lys Ser Glu Arg Pro Leu Glu Glu Gln Leu 
            980                 985                 990         


Tyr Gly Phe Cys Asn Gln Lys Val  Ala Gly Gly Thr Ala  Asn Arg Ile 
        995                 1000                 1005             


Gly Ile  Phe Tyr Asp Gly Glu  Asn Pro Val Leu Asn  Arg Asn Val 
    1010                 1015                 1020             


Val Ile  Ala Lys Leu Tyr Gly  Thr Glu Gly Leu Leu  Ser Glu Cys 
    1025                 1030                 1035             


Leu Gln  Asp Asp Arg Val Thr  Lys Ala Asp Ile Glu  Lys Tyr Tyr 
    1040                 1045                 1050             


Lys Leu  Ala Asp Ser Asp Ser  Leu Lys Ala Val Phe  Lys Tyr Gly 
    1055                 1060                 1065             


Gly Cys  Lys Asn Gln Lys Gln  Glu Glu Glu Arg Arg  Glu Tyr Gln 
    1070                 1075                 1080             


Gln His  Lys Asn Arg Ile Glu  Leu Val Asp Ile Leu  Lys Tyr Ser 
    1085                 1090                 1095             


Asp Leu  Leu Asn Asp Phe Met  Ser Gln Leu Ile Ser  Trp Cys Tyr 
    1100                 1105                 1110             


Leu Arg  Glu Arg Asp Arg Met  Tyr Phe Gln Met Gly  Leu His Tyr 
    1115                 1120                 1125             


Ile Arg  Leu Tyr Tyr Gly Lys  Asn Ile Val Glu Lys  Asp Ser Arg 
    1130                 1135                 1140             


Phe Arg  Ile Leu Gln Ser Lys  Glu Val Arg Ala Gly  Gly Glu Arg 
    1145                 1150                 1155             


Gly Ile  His Leu Thr Asp Gly  Ala Ile Leu Tyr Gln  Leu Glu Ala 
    1160                 1165                 1170             


Ile Tyr  Thr Tyr Glu Tyr Pro  Val Tyr Ala Leu Asp  Glu Glu Gly 
    1175                 1180                 1185             


Asn Ala  Thr Val Ser Lys Lys  Ala Lys Ser Gly Ser  Thr Met Ala 
    1190                 1195                 1200             


Asn Ser  Ile Lys Ala Phe Cys  Lys Glu Tyr Cys Glu  Gly Asp Ala 
    1205                 1210                 1215             


Ser Ala  Tyr Glu Met Gly Leu  Arg Leu Phe Glu Asn  Pro Ile Glu 
    1220                 1225                 1230             


Glu Gly  Glu Ser Ile Ser Phe  Arg Asn Tyr Ile Asp  His Phe Lys 
    1235                 1240                 1245             


Tyr Tyr  Ser Gln Arg Asp Arg  Ser Ile Leu Asp Leu  Tyr Ser Gln 
    1250                 1255                 1260             


Val Phe  Ala Thr Tyr Phe Arg  Asn Asp Lys Lys Leu  Lys Lys Ser 
    1265                 1270                 1275             


Val Thr  Phe Ile Phe Lys Asn  Ile Leu Ala Arg His  Phe Val Ile 
    1280                 1285                 1290             


Thr Lys  Thr Val Leu Asp Val  His Asp Glu Pro Lys  Lys Asp Lys 
    1295                 1300                 1305             


Lys Asn  Pro Lys Ile Arg Thr  Tyr Lys Gln Ala Glu  Ile Arg Ile 
    1310                 1315                 1320             


Ala Glu  Lys Asp Gly Leu Glu  Ser Asp Val Thr Ile  His Lys Tyr 
    1325                 1330                 1335             


Thr Lys  Glu Asp Leu Asp Glu  Ala Tyr Lys Lys Lys  Ala Glu Gly 
    1340                 1345                 1350             


Asp Arg  Asn Ile Arg Val Pro  Lys Lys Gly Gly Lys  Tyr Ser Ile 
    1355                 1360                 1365             


Leu Leu  Tyr Asp Glu Ser Phe  Ile Glu Arg Leu Tyr  Arg Ile Leu 
    1370                 1375                 1380             


Asn Tyr  His Lys 
    1385         


<210>  466
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  466

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  467
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  467

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Leu Gly Thr Asp Thr 
            20                  25                  30          


Ile Gly Leu Lys Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Asp Lys Pro Lys Lys 
    50                  55                  60                  


Trp Lys Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Glu Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Ser Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Met Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Tyr Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ser Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Lys Asp Arg Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Lys Glu Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Gln Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Phe 
            660                 665                 670         


Ile Arg Lys Asn Phe Pro Glu Asp Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Asp Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asn Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ser 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Asp Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Asp Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asn  Ser Glu Lys Lys Glu  Ala Tyr Gln Lys Ile  Glu Val Asn 
    1100                 1105                 1110             


Gly Asp  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Val  Tyr Ala Pro Asp Glu  Lys Gly Asp 
    1130                 1135                 1140             


Ile Leu  Lys Glu Gln Cys Thr  Lys Gly Gly Ala Gly  Gly Lys Ile 
    1145                 1150                 1155             


Ser Ala  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Lys Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Lys Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Lys Gln 
    1250                 1255                 1260             


Thr Thr  Ser Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Ser Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Lys  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Val Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Gly Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Pro Asn 
    1370                 1375                 1380         


<210>  468
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  468

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Gly Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asp 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  469
<211>  949
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  469

Met Pro His Gln Lys Lys Met Ala Glu Arg Ile Lys Phe Val Asn Tyr 
1               5                   10                  15      


Gly Tyr Tyr Leu Arg Leu Lys Lys Asn Cys Ala Asp Ser Phe Glu Tyr 
            20                  25                  30          


Tyr Trp Cys Asp Tyr Ile Lys Glu Phe Ile Glu Glu Asn Tyr Val Thr 
        35                  40                  45              


Lys Ile Lys Glu Ala Lys Gly Lys Asn Gly Arg Gln Leu Thr Glu Glu 
    50                  55                  60                  


Asn Cys Asn Ser Glu Ala Met Leu Ser Lys Cys Trp His Asp Met Ile 
65                  70                  75                  80  


Arg His Met Cys Ala Lys Tyr Met Asp Leu Gly Lys Ala Val Tyr His 
                85                  90                  95      


Phe Met Leu Pro Gly Lys Ala Glu Gly Asn Asp Leu Cys Leu Asp Arg 
            100                 105                 110         


Leu Asn Asp Ser Phe Ser Lys Gly Ile Thr Ser Phe Asp Tyr Glu Asn 
        115                 120                 125             


Ile Lys Ala Glu Glu Asn Leu Gln Lys Ala Met Phe Gly Val Leu Val 
    130                 135                 140                 


Ser Gly Thr Phe Asn Phe Ser Arg Ser Val Ala Asp Tyr Ser Gly Pro 
145                 150                 155                 160 


Ala Ala Ala Lys Leu Ala Lys Glu Leu Arg Ala Glu Gly Lys Thr Leu 
                165                 170                 175     


Asn Glu Asp Val Leu Met Val Asp Glu Ala His Leu Lys Ala Ile Leu 
            180                 185                 190         


Tyr Ser Asp Ala Lys Arg Lys Leu Leu Arg Tyr Phe Gly Gly Ser Ser 
        195                 200                 205             


Ala Cys Glu Ala Leu Gly Leu Asp Lys Asp Lys Met Val Leu Glu Phe 
    210                 215                 220                 


Arg Gln Ile Phe Arg Gly Leu Arg Asn Ser Ala Phe His Tyr Thr Asp 
225                 230                 235                 240 


Gly Lys Lys Ala Asp Ile Lys Phe Asp Val Thr Arg Gln Leu Trp Ile 
                245                 250                 255     


Gln Asp Val Gln Ala Asn Lys Gln Leu Ile Leu Asp Lys Tyr Tyr Ser 
            260                 265                 270         


Asn Asn Val Cys Arg Tyr Tyr Lys Pro Glu Met Val Lys Lys Leu Ile 
        275                 280                 285             


Gly Asn Leu Tyr His Gly Tyr Val Glu Gln Glu Ala Gln Ile Pro Ala 
    290                 295                 300                 


Phe Arg Thr Val Trp Lys Arg Lys Asp Phe Ala Lys Tyr Leu Asn Asp 
305                 310                 315                 320 


Ser Asn Phe Leu Pro Val Asn Ile Lys Asn Asp Val Lys Glu Arg Thr 
                325                 330                 335     


Val Phe Glu Gly Ala Leu Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg 
            340                 345                 350         


Lys Tyr Thr Val Gly Gln Asp Ala Pro Lys Tyr Phe Phe Glu Ala Val 
        355                 360                 365             


Arg Ala Tyr Ser Asp Glu His Ala Lys Asn Lys Gln Asp Pro Tyr Ala 
    370                 375                 380                 


Asn Gln Ala Lys Asn Phe Trp Asp Tyr Val Glu Lys Leu Gln Lys Ser 
385                 390                 395                 400 


Tyr Glu Lys Gly Thr Leu Thr Phe Gly Ala Val Cys Gln Thr Ile Met 
                405                 410                 415     


Thr Glu Phe Val Gln Gln Asn Ser Lys Ala Thr Glu Lys Glu Gly Glu 
            420                 425                 430         


Ile Tyr Gln His Phe Lys Val Leu Phe Pro Leu Cys Met Gln Arg Gly 
        435                 440                 445             


Phe Glu Lys Tyr Val Lys Glu Lys His Gly Tyr Leu Leu Lys Pro Trp 
    450                 455                 460                 


Leu Asp Thr Val Val Arg Glu Asn Val Leu Gln Asp Ala Ala Ile Thr 
465                 470                 475                 480 


Cys Phe Asp Asp Leu Met Arg Asp Ala Glu Asp Arg Glu Tyr Ser Trp 
                485                 490                 495     


Tyr Val Val Ala His Phe Ile His Pro Lys Lys Leu Asn His Phe Val 
            500                 505                 510         


Gly Ala Leu Lys Asp Tyr Leu Gln Phe Lys Gln Asp Ile Phe Arg Arg 
        515                 520                 525             


Cys Ser Phe Ala Asn Ile Tyr Ser Glu Gly Glu Leu Ser Gln Lys Lys 
    530                 535                 540                 


Ala Met Leu Ala Glu Lys Glu Ala Glu Ile Ser Glu Ile Leu Arg Val 
545                 550                 555                 560 


Met Glu Phe Val Arg Gly Ile Thr Gly Arg Val Ser Lys Thr Phe Ser 
                565                 570                 575     


Asp Tyr Tyr Glu Asn Glu Glu Val Tyr Ala Asn Tyr Leu Gly Lys Tyr 
            580                 585                 590         


Ile Asp Phe Pro Lys Thr Asp Gly Ile Ser Val Phe Glu Ser Phe Arg 
        595                 600                 605             


Asp Phe Cys Thr Asn Thr Leu Pro Asp Gly Asn Val Leu Asp Val Tyr 
    610                 615                 620                 


Met Asp Glu Lys Asn Pro Arg Leu Leu Lys Asn Val Glu Leu Ala Arg 
625                 630                 635                 640 


Met Tyr Ala Gly Gly Asp Val Ala Leu Lys Lys Arg Lys Arg Ile Thr 
                645                 650                 655     


Ala Lys Asp Leu Gln Arg Tyr Tyr Gly Asn Glu Val Ala Val Gln Lys 
            660                 665                 670         


Ile Leu Gln Lys Gly Leu Cys Ser Thr Arg Glu Glu Gln Gln Arg Val 
        675                 680                 685             


Leu Glu Gln Gln Asn Leu Arg Gly Arg Ile Thr Leu Asn Asp Val Thr 
    690                 695                 700                 


Glu Ile Gln Glu Ile Ile Ser Asp Met Leu Ser Gln Leu Val Thr Phe 
705                 710                 715                 720 


Ser Tyr Phe Arg Glu Arg Asp Gln Met Tyr Leu Leu Leu Gly Phe Tyr 
                725                 730                 735     


Tyr Met Ala Leu Gln Thr Asn Arg Gly Ser Ser Trp Gly Asn Glu Thr 
            740                 745                 750         


Ile Asp Phe Cys Ala Gly Lys Lys Ile Ser Ile Lys Gln Gly Trp Val 
        755                 760                 765             


Leu His Gln Val Arg Ser Val Phe Thr Tyr Gly Leu Lys Leu Tyr Ser 
    770                 775                 780                 


Glu Leu Asp Glu Lys Gly Val Gly Gly Gln Leu Ser Ser Lys Ile Val 
785                 790                 795                 800 


Ala Phe Glu Arg Val His Arg Thr Ser Leu Ala Cys Ala Leu Arg Leu 
                805                 810                 815     


Phe Met Asp Glu Asn Cys Ser Arg Arg Ala Val Asp Val Arg Asn Tyr 
            820                 825                 830         


Val Asp His Phe Lys Tyr Tyr Phe Lys Ala Asp Arg Ser Ile Met Glu 
        835                 840                 845             


Leu Tyr Ser Ala Tyr Tyr Asp Cys Phe Phe Asp Tyr Ser Thr Lys Met 
    850                 855                 860                 


Arg Lys Ser Val Leu Leu Asn Phe Ile Ser Ile Leu Glu Arg His Phe 
865                 870                 875                 880 


Val Val Ser Lys Leu Arg Val Asn Cys Leu Glu Glu Arg Cys Ser Val 
                885                 890                 895     


Ser Phe Ala Glu Ser Leu Lys Ser Glu Lys Phe Thr Tyr Lys Leu Glu 
            900                 905                 910         


Ala Asp Ala Asn Lys Lys Ser Lys Glu Gln Thr Val Glu Phe Pro Ala 
        915                 920                 925             


Arg Asp Lys Glu Phe Leu Glu Ser Leu Gln Ala Glu Leu Glu Tyr Lys 
    930                 935                 940                 


Glu Gly Tyr Asn Ser 
945                 


<210>  470
<211>  1353
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  470

Met Lys Val Thr Lys Ala Glu Lys Leu Arg Val Ala Val Ser Arg Lys 
1               5                   10                  15      


Leu Asn Asn Glu Asp Lys Arg Ala Val Leu Tyr Lys Thr Pro Asn Pro 
            20                  25                  30          


Gly Gln Thr Cys Gly Thr Val Lys Lys Gln Leu Ala Asn Arg Val Glu 
        35                  40                  45              


Arg Ala Asn Lys Leu Tyr Gly Val Phe Phe Arg Ser Asp Val Pro Glu 
    50                  55                  60                  


Thr Leu Gln Tyr His Phe Glu Glu Leu Val Thr Tyr Ala Ala Gln Ser 
65                  70                  75                  80  


Thr Ser Pro Asn Glu Phe Arg Gln Lys Ala Ser Gln Tyr Arg Glu Cys 
                85                  90                  95      


Glu Lys Lys Asp Lys Phe Gly Lys Met Arg Lys Tyr Pro Ile Phe Arg 
            100                 105                 110         


Cys Ser Tyr Ala Pro Ser Gly Lys Asn Met Lys Lys Val Met Glu Leu 
        115                 120                 125             


Tyr Val Arg Glu Arg Met Lys Asp Glu Trp Gln Ser Gln Ala Tyr Arg 
    130                 135                 140                 


Thr Ala Ala Ile Glu Ile Leu Leu Cys Ile Cys Asn Lys Asp Phe Ser 
145                 150                 155                 160 


Lys Gln Leu Ser Arg Val Asp Ala Arg Ile Phe Ala Asp Phe Tyr Asn 
                165                 170                 175     


Ala Ser Lys Ala Cys Pro Gln Pro Tyr Ile Gly Lys Ser Thr Gly Val 
            180                 185                 190         


Leu Glu Ala Ala Phe Thr Ser Val Met Lys Gln Met Ser Leu His Ala 
        195                 200                 205             


Lys Ala Asn Ala Ser Asn Lys Ile Trp Trp Leu Gln Asn Gln Leu Arg 
    210                 215                 220                 


Thr Ile Glu Leu Asn Lys Lys Ile Val Lys Ile Ser Asp Phe Lys Tyr 
225                 230                 235                 240 


Glu Tyr Ala Thr Glu Asp Arg Met Arg Ala Ile Leu Val Arg Met Arg 
                245                 250                 255     


Lys Ser Leu Lys Arg Gly Thr Asn Gly Asp Ile Ala Val Ala Leu Leu 
            260                 265                 270         


Gln Gly Ile Ala Gln Met Asn Gly Lys Thr Leu Ser Gly Val Leu Glu 
        275                 280                 285             


Glu Leu Ser Ala Asn Ser Glu Thr Lys Glu Gln Leu Ile Lys Phe Leu 
    290                 295                 300                 


Lys Ala Val His Glu Asp Tyr His Lys Thr Pro Ile Leu Lys Ala Ile 
305                 310                 315                 320 


Arg Asn Gln Asp Val Lys Val Gln Val His Glu Val Asp Pro Val Ser 
                325                 330                 335     


Pro Glu Gly Arg Ala Leu Asp Leu Ala Ser Ile Asn Val Ser Lys Gly 
            340                 345                 350         


Asn Glu Arg Lys Lys Tyr Lys Val Ala Leu Thr Gln Thr Leu Gly Asn 
        355                 360                 365             


Tyr Ala Lys Ser Pro Lys Asp Ala Thr Gln Thr Leu Lys Ala Ile Lys 
    370                 375                 380                 


Gly Val Leu Leu Asp Tyr Phe Met Trp Leu Asp Ser Asp Val Lys Ala 
385                 390                 395                 400 


Glu Phe Leu Glu Asp Asn Asn Leu Trp Lys Ile Pro Asn Arg Thr Glu 
                405                 410                 415     


Glu Tyr Phe Asp Asn Asn Phe Val Pro Ile Asp Asp Lys Lys Asp Asp 
            420                 425                 430         


Lys Ile Glu Ala Ile Glu Asp Phe Ala Ser Ile Trp Arg Gln Glu Arg 
        435                 440                 445             


Val Lys Asn Ser Arg Ile Lys Ala Arg Met Asn Tyr Val Asn Cys Gly 
    450                 455                 460                 


Lys Tyr Gln Gln Leu Ile Lys Gln Glu Thr Asp Asp Phe Arg Ile Cys 
465                 470                 475                 480 


Trp Ile Ser Tyr Ala Lys Asp Phe Val Glu Lys Asn Tyr Val Ser Lys 
                485                 490                 495     


Asn Arg Gln Phe Thr Gln Gly Asp Cys Phe Ser Thr Lys Met Leu Leu 
            500                 505                 510         


Glu Cys Trp Lys Glu Ile Ile Arg Phe Ile Cys Gly Lys Tyr Ile Asp 
        515                 520                 525             


Ile Gly Lys Ala Val Tyr His Phe Ala Met Pro Glu Thr Met Asn Ala 
    530                 535                 540                 


Arg Asp Ser Leu Ala Tyr Gly Val Leu Gly Glu Lys Tyr Lys Glu Gly 
545                 550                 555                 560 


Ile Ser Ser Phe Asp Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln 
                565                 570                 575     


Arg Asp Ile Ala Lys Ala Ala Val Ala Ala Ile His Ala Phe Ser Gly 
            580                 585                 590         


Ser Val Ile Asp Asp Lys Lys Pro Val Glu Asp Ile Leu Phe Ile Lys 
        595                 600                 605             


Asp Glu Glu Leu Gln Glu His Ala Lys Ala Asp Asp Val Ile Val Lys 
    610                 615                 620                 


Gln Ile Leu Arg Phe Tyr Gly Gly Phe Ser Ser Val Glu Gly Arg Glu 
625                 630                 635                 640 


Lys Leu Glu Gly Met Ala Leu Ala Lys Glu Val Leu Ser Gln Leu Lys 
                645                 650                 655     


Ala Ile Arg Asn Glu Asn Phe His Phe Thr Gln Gly Lys Arg Lys Asn 
            660                 665                 670         


Val Glu Glu Asn Ile Pro Leu Thr Lys Ala Leu Trp Glu Asn Glu Glu 
        675                 680                 685             


Lys Val Tyr Arg Gln Thr Val Lys Glu Thr Tyr Tyr Ser Asn Asn Val 
    690                 695                 700                 


Ser Met Phe Tyr Ser Gln Glu Val Ile Gln Lys Leu Val Ala Glu Leu 
705                 710                 715                 720 


Tyr Gln Asn Asn Asn Val Ala Glu Ala Gln Ile Pro Ala Phe Arg Thr 
                725                 730                 735     


Ile Trp Lys Arg Lys Asp Leu Pro Glu Tyr Ile Gly Ser Leu Asn Ile 
            740                 745                 750         


Ser Trp Asp Lys Thr Glu Pro Lys Gln Val Ile Tyr Glu Gly Ala Leu 
        755                 760                 765             


Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Lys Ser Gly 
    770                 775                 780                 


Glu Ala Lys Lys Leu Phe Phe Asp Ala Val Met Asp Asn Ala Thr Glu 
785                 790                 795                 800 


Met Glu Lys Ser Ser Asn Ala Asp Ser Arg Asn Gln Glu Lys Lys Ala 
                805                 810                 815     


Leu Ala Asn Ala Gly Lys Asn Phe Arg Asp Tyr Val Asn Gly Leu Asn 
            820                 825                 830         


Ala Ser Thr Leu Gly Glu Val Cys Gln Phe Ile Gln Asn Glu Tyr Asn 
        835                 840                 845             


Gln Gln Asn Arg Gly Lys Gln Glu Gln Glu Ile Tyr Lys His Phe Lys 
    850                 855                 860                 


Met Leu Leu Pro Ile Cys Met Arg Lys Ala Phe Gln Arg Tyr Ile Asp 
865                 870                 875                 880 


Glu Lys His Ser Phe Ile Lys Lys Pro Gly Glu Leu Pro Gln Thr Thr 
                885                 890                 895     


Glu Asp Tyr Leu Glu Asn Val Lys Val Ala Cys Pro Glu Lys Lys Ile 
            900                 905                 910         


Lys Leu Gly Arg Trp Phe Thr Phe Ala His Phe Ile His Pro Arg Glu 
        915                 920                 925             


Leu Asn Phe Leu Ile Gly Asp Phe Met Asn Tyr Ile Gln Tyr Arg Glu 
    930                 935                 940                 


Asp Val Leu Arg Arg Ser Glu His Ala Gly Gln Phe Ser Asp Thr Thr 
945                 950                 955                 960 


Glu Arg Asp Gly Glu Lys Ala Val Val Asp His Ala Val Gln Lys Ala 
                965                 970                 975     


Lys Asp Leu Leu Gly Val Leu Gly Phe Val Arg His Ile Ser Gly Arg 
            980                 985                 990         


Val Ser Asn Glu Phe Thr Asp Tyr  Tyr Ala Asp Arg Ala  Glu Tyr Asp 
        995                 1000                 1005             


Glu Tyr  Met Ala Lys Tyr Phe  Glu Pro Asp Val Gln  Ile Glu Gln 
    1010                 1015                 1020             


Tyr Asp  Leu Tyr Gly Asp Ala  Lys Asn Ala Lys Val  Ile Arg Asn 
    1025                 1030                 1035             


Ile Glu  Leu Ala Arg Met Tyr  Ala Gly Asp Ser Leu  Met Ser Ala 
    1040                 1045                 1050             


Ser Tyr  Arg Lys Ile Thr Lys  Lys Glu Ile Glu Thr  Tyr Tyr Ala 
    1055                 1060                 1065             


Lys Lys  Asp Glu Ile Ala Gln  Leu Gln Ser Gln Gly  Ile Cys Asn 
    1070                 1075                 1080             


Ser Lys  Lys Glu Gln Glu Asp  Ile Val Ala Phe Gln  Lys Leu Lys 
    1085                 1090                 1095             


Asn Arg  Ile Thr Leu Asn Glu  Val Thr Asp Leu Trp  Ser Leu Val 
    1100                 1105                 1110             


Asn Glu  Leu Leu Gly Asn Leu  Val Ser Leu Ala Tyr  Leu Arg Glu 
    1115                 1120                 1125             


Arg Asp  Glu Met Tyr Leu Phe  Leu Gly Phe Tyr Tyr  Met Ala Leu 
    1130                 1135                 1140             


Arg His  Pro Glu Gly Trp Thr  Asn Glu Ile Met Asn  Ser Val Ser 
    1145                 1150                 1155             


Asn Glu  Lys Tyr Ala Val Lys  Glu Gly Leu Val Leu  Tyr Gln Thr 
    1160                 1165                 1170             


Val Ala  Val Phe Asp Phe Gly  Thr Lys Leu Leu Phe  Gln Asn Asp 
    1175                 1180                 1185             


Asn Gln  Lys Trp Glu Glu Thr  Thr Gly Tyr Lys Trp  Gln His Phe 
    1190                 1195                 1200             


Ile Asp  Asn His Lys Glu Ser  Tyr Ala Cys Ile Leu  Pro Leu Phe 
    1205                 1210                 1215             


Glu Ile  Ala Lys Cys Glu Thr  Glu Ala Arg Ala Val  Arg Asn Tyr 
    1220                 1225                 1230             


Val Asp  His Phe Lys Tyr Tyr  Ser Asn Glu Asp Arg  Ser Ile Leu 
    1235                 1240                 1245             


Glu Leu  Tyr Gly Lys Phe Tyr  Thr His Leu Phe Gly  Tyr Ser Thr 
    1250                 1255                 1260             


Arg Leu  Arg Lys Ser Val Leu  Gln Ile Leu Ala Gln  Thr Leu Glu 
    1265                 1270                 1275             


Lys His  Gly Ile Ser Ala Gly  Ile Gln Phe Asp Gly  Thr Thr Val 
    1280                 1285                 1290             


Lys Ala  Thr Arg Cys Asp Met  Lys Ser Val Glu Phe  Thr Tyr Lys 
    1295                 1300                 1305             


Tyr Glu  Glu Lys Leu Asn Glu  Gln Lys Thr Val Leu  Arg Thr Ile 
    1310                 1315                 1320             


Ser Leu  Pro Ala Lys Ser Glu  Gly Phe Ile Thr Ala  Val Cys Glu 
    1325                 1330                 1335             


Met Leu  Lys Gln Lys Lys Gly  Asp His Thr Glu Asn  Thr Leu Cys 
    1340                 1345                 1350             


<210>  471
<211>  1268
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  471

Met Lys Val Ser Lys Val Asn His Arg Arg Ala Ala Val Ala Val Asn 
1               5                   10                  15      


Lys Lys Ser Val Thr Val Asn Gly Ile Leu Tyr Asp Ala Pro Val Lys 
            20                  25                  30          


Lys Asn Val Lys Thr Gly Asn Met Ser Ala Tyr Val Ser Ser Lys Tyr 
        35                  40                  45              


Val Ile Asp Asn Val Val Lys Asn Ser Ser Arg Leu Tyr Ser Pro Phe 
    50                  55                  60                  


Ser Ser Lys Arg Ile Val Ile Asp Arg Glu Lys Ile Arg Ile Ala Asp 
65                  70                  75                  80  


Arg Leu Lys Gln Cys Tyr Val Asn Phe Val Lys Tyr Tyr Leu Ser Asn 
                85                  90                  95      


Gly Ser Leu Asn Glu Gln Gln Met Arg Phe Asn Pro Asn Asn Thr Tyr 
            100                 105                 110         


Met Ala Asp Ser Arg Val His Phe Cys Val Pro Ser Gly Ile Asp Ile 
        115                 120                 125             


Glu Ser Leu Ile Asn Ser Ile Val Asp Ser Ser Leu Arg Lys Ser Leu 
    130                 135                 140                 


Lys Arg Thr Tyr Arg Phe Glu Thr Asn Tyr Gly Glu Lys Asn Thr Phe 
145                 150                 155                 160 


Asn Leu Pro Asp Leu Val Lys Lys Ser Ile Lys Ile Tyr Cys Thr Asp 
                165                 170                 175     


Glu Lys Arg Lys Leu Asn Asp Arg Glu Glu Gln Glu Met Tyr Val Leu 
            180                 185                 190         


Phe Ser Tyr Met Tyr Glu Asp Lys Tyr Lys Asp Arg Gln Lys Val Leu 
        195                 200                 205             


Ile Ala Asn Ser Ile Ser Asn Gln Ala Thr Lys Val Lys Val Cys Asp 
    210                 215                 220                 


Asp Glu Ser Arg Leu Ile Lys Leu Ser Ile Ala Asp Thr Lys Lys Lys 
225                 230                 235                 240 


Pro Leu Trp Asp Phe Ile Val Asp Tyr Ala Asn Ser Asp Lys Asn Gly 
                245                 250                 255     


Gln Tyr Thr Ile Leu Arg Asn Ile Arg Lys Ser Ile Val Leu Phe Val 
            260                 265                 270         


Cys Gly Val Asp Val Tyr Arg Asn Ile Glu Asn Asn Asp Asn Leu Asp 
        275                 280                 285             


Ile Trp Lys Trp Glu Glu Tyr Gly Ile Gln Glu Ser Gln Leu Phe Val 
    290                 295                 300                 


Lys Ile Glu Asn Cys Tyr Thr Thr Lys Gly Glu Asp Ile Ala Leu Asn 
305                 310                 315                 320 


Glu Ile Arg Asn Val Asn Leu Asp His Tyr Met Lys Ala Ile Gly Val 
                325                 330                 335     


Leu Asp Asp Glu Arg Ser Lys Phe Trp Phe Gln His Tyr Glu Asn Thr 
            340                 345                 350         


Ile Glu Ala Leu Phe Ser Lys Lys Ser Lys Arg Lys Ile Glu Arg Ile 
        355                 360                 365             


Lys Thr Ala Tyr Leu Cys Glu Tyr Leu Trp Lys Asn Phe Cys Ser Tyr 
    370                 375                 380                 


Val Ala Leu Lys Tyr Val Asp Leu Gly Lys Gly Val Tyr His Phe Thr 
385                 390                 395                 400 


Met Ser Asp Lys Leu Ser Leu Met Asn Lys Asn Thr Asn Glu Asn Gly 
                405                 410                 415     


Ile Lys Phe Gly Glu Val Asp Ser Arg Phe Asn Lys Gly Ile Ser Ser 
            420                 425                 430         


Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Thr Ile Asp Arg Asn Ile 
        435                 440                 445             


Ser Thr Tyr Thr Thr Phe Ala Thr Asn Ile Phe Ala Lys Ser Val Ile 
    450                 455                 460                 


Lys Asp Ser Tyr Arg Gln Lys Lys Ala Gly Asn Ser Asp Ala Leu Gln 
465                 470                 475                 480 


Tyr Asp Asp Glu Thr Tyr Tyr Asn Arg Lys Ala Met Asn Pro Tyr Ala 
                485                 490                 495     


Leu Lys Arg Val Leu Arg Tyr Trp Gly Gly Gln Ser Arg Trp Lys Ser 
            500                 505                 510         


Glu Leu Glu Glu Leu Asn Val Ala Glu Leu Cys Ile Asp Ile Lys Asn 
        515                 520                 525             


Arg Leu Ser Lys Ile Arg Asn Ser Gly Val His Tyr Thr Ser Thr Ser 
    530                 535                 540                 


Ala Leu Lys Gly Asn Asp Asp Asp Ser Ile Val Gly Met Leu Ile Lys 
545                 550                 555                 560 


Lys Asp Phe Asp Asp Ile Lys Asp Val Tyr Ala Ser Lys Tyr Tyr Ser 
                565                 570                 575     


Asn Asn Val Trp Met Phe Tyr Asn Thr Asp Lys Ile Ser Lys Met Met 
            580                 585                 590         


Glu Tyr Leu Tyr Gln Asp Asp Ser Asn Ile Arg Asp Ala Gln Ile Pro 
        595                 600                 605             


Ala Phe Asn Ser Val Ile Lys Arg Lys Asp Met Ala Glu Val Ile Glu 
    610                 615                 620                 


Lys Ile Val Lys Lys Asn Ser Tyr Lys Thr Ile Lys Glu Pro Tyr Gln 
625                 630                 635                 640 


Arg Glu Lys Tyr Arg Ser Cys Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
                645                 650                 655     


Tyr Asn Arg Phe Ile Lys Gln Asp Asn Leu Lys Asp Gln Val Ile Gln 
            660                 665                 670         


Ile Ile Asp Ser Asn Thr Glu Leu Ile Gly Asp Asn Ser Arg Ala Val 
        675                 680                 685             


Asp Asn Leu Lys Lys Arg Ile His Asp Val Asp Ser Gln Thr Met Ser 
    690                 695                 700                 


Phe Gly Glu Leu Cys Gln Val Ile Met Thr Asp Tyr Asn Met Gln Asn 
705                 710                 715                 720 


Gln Glu Asn Lys Ser Ile Lys Ser Lys Glu Arg Gln Asp Lys Asp Arg 
                725                 730                 735     


Lys Asn Gly Ile Asp Asn Ser Tyr Lys His Phe Pro Leu Leu Leu His 
            740                 745                 750         


His Leu Ile Lys Val Ser Phe Leu Lys Phe Ile Lys Thr Asp Glu Lys 
        755                 760                 765             


Leu Ala Phe Ile Arg Glu Pro Arg Ile Thr Glu Trp Asp Lys Thr Leu 
    770                 775                 780                 


Glu Gln Phe Glu Ala Gln Ile Gln Thr Val Asp Ile Tyr Asn Ser Leu 
785                 790                 795                 800 


Lys Met Met Val Ala Glu Asn Lys Ser Leu Leu Asp Trp Tyr Thr Leu 
                805                 810                 815     


Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asp Val 
            820                 825                 830         


Lys Asn Tyr Ile Gln Tyr Leu Ser Asn Ile Asp Lys Arg Ala Gly Ser 
        835                 840                 845             


Val Lys Asn Asn Lys Ser Ala Ser Thr Glu Val Lys Ile Arg Gln Tyr 
    850                 855                 860                 


Ser Glu Ile Val Arg Ile Leu Asp Phe Ser Leu Gln Tyr Ile Gly Arg 
865                 870                 875                 880 


Val Ser Asn Asp Val Thr Asp Tyr Phe Val Asp Glu Asp Glu Tyr Ala 
                885                 890                 895     


Ala Phe Leu Ser Lys Tyr Val Glu Phe Ser Gly Asn Asp Ile Val Ser 
            900                 905                 910         


Met Lys Ala Phe Cys Gln Ser Arg Thr Ala Asn Gly Lys His Thr Ile 
        915                 920                 925             


Gly Leu Tyr Cys Asp Gly Ala Asn Pro Ile Met Asn Arg Asn Ile Ala 
    930                 935                 940                 


Tyr Ala Lys Met Tyr Gly Asn Asp Glu Ile Leu Ser Tyr Ile Tyr Asn 
945                 950                 955                 960 


Lys Val Thr Lys Lys Asp Ile Glu Lys Tyr Tyr Val Ser Gln Asp Asn 
                965                 970                 975     


Leu Glu Lys Val Phe Ala Asp Gly Lys Cys Gln Asp Val Gln Gln Gln 
            980                 985                 990         


Asn Ala Leu Cys Asp Phe Gln Lys  Met Lys Asn His Ile  Glu Leu Thr 
        995                 1000                 1005             


Glu Val  Ser Ile Tyr Thr Asp  Ile Leu Asn Asp Phe  Met Ala Gln 
    1010                 1015                 1020             


Phe Ile  Ser Trp Ala Tyr Leu  Arg Glu Arg Asp Leu  Met Tyr Phe 
    1025                 1030                 1035             


Gln Leu  Gly Leu Asn Tyr Ile  Arg Met Phe Tyr Gly  Thr Tyr Glu 
    1040                 1045                 1050             


Leu Glu  Glu Lys Tyr Tyr Lys  Leu His Gly Glu Asn  Ile Asn Ile 
    1055                 1060                 1065             


Glu Lys  Gly Ala Leu Leu Tyr  Gln Ile Val Ala Met  Tyr Ser His 
    1070                 1075                 1080             


Glu Leu  Pro Ile Tyr Lys Val  Asp Glu Ser Gly Ile  Ala Ile Leu 
    1085                 1090                 1095             


Ala Glu  Lys Gln Gly Ser Ser  Gly Ala Ser Ile Lys  Ser Phe Val 
    1100                 1105                 1110             


Thr Glu  Tyr Cys Lys Glu Glu  Met Lys Lys Ala Tyr  Thr Tyr Glu 
    1115                 1120                 1125             


Asn Gly  Leu Glu Leu Phe Glu  Asp Val Asn Gln His  Asp Asp Leu 
    1130                 1135                 1140             


Ser Lys  Leu Arg Asn Asp Phe  Ala His Met Arg Tyr  Met Ser Ala 
    1145                 1150                 1155             


Arg Asp  Lys Ser Ile Met Asp  Ile Val Ser Glu Ile  Tyr Asn Gly 
    1160                 1165                 1170             


Phe Phe  Ile Tyr Asp Thr Lys  Leu Lys Lys Ser Val  Ser Phe Ile 
    1175                 1180                 1185             


Phe Lys  Asn Ile Leu Met Arg  Tyr Ala Val Asp Val  Asn Ile Glu 
    1190                 1195                 1200             


Phe Cys  His Lys Gly Asp Asn  Glu Asp Thr Asn Asn  Leu Ile Arg 
    1205                 1210                 1215             


Ile Lys  Asp Glu Val Gly Leu  Tyr Ser Asp Lys Tyr  Thr Tyr Lys 
    1220                 1225                 1230             


Val Glu  Asp Asn Asp Thr Val  Asp Ile Glu Val Arg  Asn Ser Glu 
    1235                 1240                 1245             


Phe Leu  Glu Gln Leu Lys Lys  Leu Leu Glu Tyr Lys  Lys Glu Ser 
    1250                 1255                 1260             


Glu Gly  Ser Glu Leu 
    1265             


<210>  472
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  472

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Leu Tyr Gln Ile Val  Ser Ala Phe Asn Phe  Gly Ser Lys 
    1205                 1210                 1215             


Leu Leu  Tyr Ile Ser Glu Asp  Gly Arg Trp Lys Met  Ala Gly Gly 
    1220                 1225                 1230             


Ala Phe  Pro Gly Lys Tyr Gly  Arg Phe Glu Asn Asp  Tyr Asn His 
    1235                 1240                 1245             


Arg Thr  Ser Leu Ser Lys Val  Ile Arg Leu Phe Glu  Asn Glu Ser 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ile Ile Tyr  Trp Arg Asp Tyr Val  Asp His Met 
    1265                 1270                 1275             


Lys Tyr  Tyr Val Asn Gln Asn  Gln Ser Ile Met Glu  Ile Tyr Ser 
    1280                 1285                 1290             


Ala Phe  Tyr Ser Lys Val Leu  Gly Tyr Ser Ala Lys  Leu Arg Lys 
    1295                 1300                 1305             


Ser Val  Val Phe Asn Leu Gln  Ala Ala Leu Glu Lys  His His Ile 
    1310                 1315                 1320             


Asn Pro  Glu Cys Ile Trp Met  Thr Ser Asp Gly Lys  Cys Ala Asp 
    1325                 1330                 1335             


Ile Lys  Leu Met Lys Asn Leu  Glu Ser Gln Lys Phe  Thr Tyr Lys 
    1340                 1345                 1350             


Leu Ala  Lys Arg Glu Gly Glu  Lys Thr Glu Arg Lys  Ile Cys Met 
    1355                 1360                 1365             


Asn Ala  Leu Asn Glu Asn Phe  Leu Lys Thr Ile Arg  Thr Ser Leu 
    1370                 1375                 1380             


Glu Tyr  Lys Lys 
    1385         


<210>  473
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  473

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Gly Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asp 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  474
<211>  1268
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  474

Met Lys Val Ser Lys Val Asn His Arg Arg Ala Ala Val Ala Val Asn 
1               5                   10                  15      


Lys Lys Ser Val Thr Val Asn Gly Ile Leu Tyr Asp Ala Pro Val Lys 
            20                  25                  30          


Lys Asn Val Lys Thr Gly Asn Met Ser Ala Tyr Val Ser Ser Lys Tyr 
        35                  40                  45              


Val Ile Asp Asn Val Val Lys Asn Ser Ser Arg Leu Tyr Ser Pro Phe 
    50                  55                  60                  


Ser Ser Lys Arg Ile Val Ile Asp Arg Glu Lys Ile Arg Ile Ala Asp 
65                  70                  75                  80  


Arg Leu Lys Gln Cys Tyr Val Asn Phe Val Lys Tyr Tyr Leu Ser Asn 
                85                  90                  95      


Gly Ser Leu Asn Glu Gln Gln Met Arg Phe Asn Pro Asn Asn Thr Tyr 
            100                 105                 110         


Met Ala Asp Ser Arg Val His Phe Cys Val Pro Ser Gly Ile Asp Ile 
        115                 120                 125             


Glu Ser Leu Ile Asn Ser Ile Val Asp Ser Ser Leu Arg Lys Ser Leu 
    130                 135                 140                 


Lys Arg Thr Tyr Arg Phe Glu Thr Asn Tyr Gly Glu Lys Asn Thr Phe 
145                 150                 155                 160 


Asn Leu Pro Asp Leu Val Lys Lys Ser Ile Lys Ile Tyr Cys Thr Asp 
                165                 170                 175     


Glu Lys Arg Lys Leu Asn Asp Arg Glu Glu Gln Glu Met Tyr Val Leu 
            180                 185                 190         


Phe Ser Tyr Met Tyr Glu Asp Lys Tyr Lys Asp Arg Gln Lys Val Leu 
        195                 200                 205             


Ile Ala Asn Ser Ile Ser Asn Gln Ala Thr Lys Val Lys Val Cys Asp 
    210                 215                 220                 


Asp Glu Ser Arg Leu Ile Lys Leu Ser Ile Ala Asp Thr Lys Lys Lys 
225                 230                 235                 240 


Pro Leu Trp Asp Phe Ile Val Asp Tyr Ala Asn Ser Asp Lys Asn Gly 
                245                 250                 255     


Gln Tyr Thr Ile Leu Arg Asn Ile Arg Lys Ser Ile Val Leu Phe Val 
            260                 265                 270         


Cys Gly Val Asp Val Tyr Arg Asn Ile Glu Asn Asn Asp Asn Leu Asp 
        275                 280                 285             


Ile Trp Lys Trp Glu Glu Tyr Gly Ile Gln Glu Ser Gln Leu Phe Val 
    290                 295                 300                 


Lys Ile Glu Asn Cys Tyr Thr Thr Lys Gly Glu Asp Ile Ala Leu Asn 
305                 310                 315                 320 


Glu Ile Arg Asn Val Asn Leu Asp His Tyr Met Lys Ala Ile Gly Val 
                325                 330                 335     


Leu Asp Asp Glu Arg Ser Lys Phe Trp Phe Gln His Tyr Glu Asn Thr 
            340                 345                 350         


Ile Glu Ala Leu Phe Ser Lys Lys Ser Lys Arg Lys Ile Glu Arg Ile 
        355                 360                 365             


Lys Thr Ala Tyr Leu Cys Glu Tyr Leu Trp Lys Asn Phe Cys Ser Tyr 
    370                 375                 380                 


Val Ala Leu Lys Tyr Val Asp Leu Gly Lys Gly Val Tyr His Phe Thr 
385                 390                 395                 400 


Met Ser Asp Lys Leu Ser Leu Met Asn Lys Asn Thr Asn Glu Asn Gly 
                405                 410                 415     


Ile Lys Phe Gly Glu Val Asp Ser Arg Phe Asn Lys Gly Ile Ser Ser 
            420                 425                 430         


Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Thr Ile Asp Arg Asn Ile 
        435                 440                 445             


Ser Thr Tyr Thr Thr Phe Ala Thr Asn Ile Phe Ala Lys Ser Val Ile 
    450                 455                 460                 


Lys Asp Ser Tyr Arg Gln Lys Lys Ala Gly Asn Ser Asp Ala Leu Gln 
465                 470                 475                 480 


Tyr Asp Asp Glu Thr Tyr Tyr Asn Arg Lys Ala Met Asn Pro Tyr Ala 
                485                 490                 495     


Leu Lys Arg Val Leu Arg Tyr Trp Gly Gly Gln Ser Arg Trp Lys Ser 
            500                 505                 510         


Glu Leu Glu Glu Leu Asn Val Ala Glu Leu Cys Ile Asp Ile Lys Asn 
        515                 520                 525             


Arg Leu Ser Lys Ile Arg Asn Ser Gly Val His Tyr Thr Ser Thr Ser 
    530                 535                 540                 


Ala Leu Lys Gly Asn Asp Asp Asp Ser Ile Val Gly Met Leu Ile Lys 
545                 550                 555                 560 


Lys Asp Phe Asp Asp Ile Lys Asp Val Tyr Ala Ser Lys Tyr Tyr Ser 
                565                 570                 575     


Asn Asn Val Trp Met Phe Tyr Asn Thr Asp Lys Ile Ser Lys Met Met 
            580                 585                 590         


Glu Tyr Leu Tyr Gln Asp Asp Ser Asn Ile Arg Asp Ala Gln Ile Pro 
        595                 600                 605             


Ala Phe Asn Ser Val Ile Lys Arg Lys Asp Met Ala Glu Val Ile Glu 
    610                 615                 620                 


Lys Ile Val Lys Lys Asn Ser Tyr Lys Thr Ile Lys Glu Pro Tyr Gln 
625                 630                 635                 640 


Arg Glu Lys Tyr Arg Ser Cys Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
                645                 650                 655     


Tyr Asn Arg Phe Ile Lys Gln Asp Asn Leu Lys Asp Gln Val Ile Gln 
            660                 665                 670         


Ile Ile Asp Ser Asn Thr Glu Leu Ile Gly Asp Asn Ser Arg Ala Val 
        675                 680                 685             


Asp Asn Leu Lys Lys Arg Ile His Asp Val Asp Ser Gln Thr Met Ser 
    690                 695                 700                 


Phe Gly Glu Leu Cys Gln Val Ile Met Thr Asp Tyr Asn Met Gln Asn 
705                 710                 715                 720 


Gln Glu Asn Lys Ser Ile Lys Ser Lys Glu Arg Gln Asp Lys Asp Arg 
                725                 730                 735     


Lys Asn Gly Ile Asp Asn Ser Tyr Lys His Phe Pro Leu Leu Leu His 
            740                 745                 750         


His Leu Ile Lys Val Ser Phe Leu Lys Phe Ile Lys Thr Asp Glu Lys 
        755                 760                 765             


Leu Ala Phe Ile Arg Glu Pro Arg Ile Thr Glu Trp Asp Lys Thr Leu 
    770                 775                 780                 


Glu Gln Phe Glu Ala Gln Ile Gln Thr Val Asp Ile Tyr Asn Ser Leu 
785                 790                 795                 800 


Lys Met Met Val Ala Glu Asn Lys Ser Leu Leu Asp Trp Tyr Thr Leu 
                805                 810                 815     


Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asp Val 
            820                 825                 830         


Lys Asn Tyr Ile Gln Tyr Leu Ser Asn Ile Asp Lys Arg Ala Gly Ser 
        835                 840                 845             


Val Lys Asn Asn Lys Ser Ala Ser Thr Glu Val Lys Ile Arg Gln Tyr 
    850                 855                 860                 


Ser Glu Ile Val Arg Ile Leu Asp Phe Ser Leu Gln Tyr Ile Gly Arg 
865                 870                 875                 880 


Val Ser Asn Asp Val Thr Asp Tyr Phe Val Asp Glu Asp Glu Tyr Ala 
                885                 890                 895     


Ala Phe Leu Ser Lys Tyr Val Glu Phe Ser Gly Asn Asp Ile Val Ser 
            900                 905                 910         


Met Lys Ala Phe Cys Gln Ser Arg Thr Ala Asn Gly Lys His Thr Ile 
        915                 920                 925             


Gly Leu Tyr Cys Asp Gly Ala Asn Pro Ile Met Asn Arg Asn Ile Ala 
    930                 935                 940                 


Tyr Ala Lys Met Tyr Gly Asn Asp Glu Ile Leu Ser Tyr Ile Tyr Asn 
945                 950                 955                 960 


Lys Val Thr Lys Lys Asp Ile Glu Lys Tyr Tyr Val Ser Gln Asp Asn 
                965                 970                 975     


Leu Glu Lys Val Phe Ala Asp Gly Lys Cys Gln Asp Val Gln Gln Gln 
            980                 985                 990         


Asn Ala Leu Cys Asp Phe Gln Lys  Met Lys Asn His Ile  Glu Leu Thr 
        995                 1000                 1005             


Glu Val  Ser Ile Tyr Thr Asp  Ile Leu Asn Asp Phe  Met Ala Gln 
    1010                 1015                 1020             


Phe Ile  Ser Trp Ala Tyr Leu  Arg Glu Arg Asp Leu  Met Tyr Phe 
    1025                 1030                 1035             


Gln Leu  Gly Leu Asn Tyr Ile  Arg Met Phe Tyr Gly  Thr Tyr Glu 
    1040                 1045                 1050             


Leu Glu  Glu Lys Tyr Tyr Lys  Leu His Gly Glu Asn  Ile Asn Ile 
    1055                 1060                 1065             


Glu Lys  Gly Ala Leu Leu Tyr  Gln Ile Val Ala Met  Tyr Ser His 
    1070                 1075                 1080             


Glu Leu  Pro Ile Tyr Lys Val  Asp Glu Ser Gly Ile  Ala Ile Leu 
    1085                 1090                 1095             


Ala Glu  Lys Gln Gly Ser Ser  Gly Ala Ser Ile Lys  Ser Phe Val 
    1100                 1105                 1110             


Thr Glu  Tyr Cys Lys Glu Glu  Met Lys Lys Ala Tyr  Thr Tyr Glu 
    1115                 1120                 1125             


Asn Gly  Leu Glu Leu Phe Glu  Asp Val Asn Gln His  Asp Asp Leu 
    1130                 1135                 1140             


Ser Lys  Leu Arg Asn Asp Phe  Ala His Met Arg Tyr  Met Ser Ala 
    1145                 1150                 1155             


Arg Asp  Lys Ser Ile Met Asp  Ile Val Ser Glu Ile  Tyr Asn Gly 
    1160                 1165                 1170             


Phe Phe  Ile Tyr Asp Thr Lys  Leu Lys Lys Ser Val  Ser Phe Ile 
    1175                 1180                 1185             


Phe Lys  Asn Ile Leu Met Arg  Tyr Ala Val Asp Val  Asn Ile Glu 
    1190                 1195                 1200             


Phe Cys  His Lys Gly Asp Asn  Glu Asp Thr Asn Asn  Leu Ile Arg 
    1205                 1210                 1215             


Ile Lys  Asp Glu Val Gly Leu  Tyr Ser Asp Lys Tyr  Thr Tyr Lys 
    1220                 1225                 1230             


Val Glu  Asp Asn Asp Thr Val  Asp Ile Glu Val Arg  Asn Ser Glu 
    1235                 1240                 1245             


Phe Leu  Glu Gln Leu Lys Lys  Leu Leu Glu Tyr Lys  Lys Glu Ser 
    1250                 1255                 1260             


Glu Gly  Ser Glu Leu 
    1265             


<210>  475
<211>  1268
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  475

Met Lys Val Ser Lys Val Asn His Arg Arg Ala Ala Val Ala Val Asn 
1               5                   10                  15      


Lys Lys Ser Val Thr Val Asn Gly Ile Leu Tyr Asp Ala Pro Val Lys 
            20                  25                  30          


Lys Asn Val Lys Thr Gly Asn Met Ser Ala Tyr Val Ser Ser Lys Tyr 
        35                  40                  45              


Val Ile Asp Asn Val Val Lys Asn Ser Ser Arg Leu Tyr Ser Pro Phe 
    50                  55                  60                  


Ser Ser Lys Arg Ile Val Ile Asp Arg Glu Lys Ile Arg Ile Ala Asp 
65                  70                  75                  80  


Arg Leu Lys Gln Cys Tyr Val Asn Phe Val Lys Tyr Tyr Leu Ser Asn 
                85                  90                  95      


Gly Ser Leu Asn Glu Gln Gln Met Arg Phe Asn Pro Asn Asn Thr Tyr 
            100                 105                 110         


Met Ala Asp Ser Arg Val His Phe Cys Val Pro Ser Gly Ile Asp Ile 
        115                 120                 125             


Glu Ser Leu Ile Asn Ser Ile Val Asp Ser Ser Leu Arg Lys Ser Leu 
    130                 135                 140                 


Lys Arg Thr Tyr Arg Phe Glu Thr Asn Tyr Gly Glu Lys Asn Thr Phe 
145                 150                 155                 160 


Asn Leu Pro Asp Leu Val Lys Lys Ser Ile Lys Ile Tyr Cys Thr Asp 
                165                 170                 175     


Glu Lys Arg Lys Leu Asn Asp Arg Glu Glu Gln Glu Met Tyr Val Leu 
            180                 185                 190         


Phe Ser Tyr Met Tyr Glu Asp Lys Tyr Lys Asp Arg Gln Lys Val Leu 
        195                 200                 205             


Ile Ala Asn Ser Ile Ser Asn Gln Ala Thr Lys Val Lys Val Cys Asp 
    210                 215                 220                 


Asp Glu Ser Arg Leu Ile Lys Leu Ser Ile Ala Asp Thr Lys Lys Lys 
225                 230                 235                 240 


Pro Leu Trp Asp Phe Ile Val Asp Tyr Ala Asn Ser Asp Lys Asn Gly 
                245                 250                 255     


Gln Tyr Thr Ile Leu Arg Asn Ile Arg Lys Ser Ile Val Leu Phe Val 
            260                 265                 270         


Cys Gly Val Asp Val Tyr Arg Asn Ile Glu Asn Asn Asp Asn Leu Asp 
        275                 280                 285             


Ile Trp Lys Trp Glu Glu Tyr Gly Ile Gln Glu Ser Gln Leu Phe Val 
    290                 295                 300                 


Lys Ile Glu Asn Cys Tyr Thr Thr Lys Gly Glu Asp Ile Ala Leu Asn 
305                 310                 315                 320 


Glu Ile Arg Asn Val Asn Leu Asp His Tyr Met Lys Ala Ile Gly Val 
                325                 330                 335     


Leu Asp Asp Glu Arg Ser Lys Phe Trp Phe Gln His Tyr Glu Asn Thr 
            340                 345                 350         


Ile Glu Ala Leu Phe Ser Lys Lys Ser Lys Arg Lys Ile Glu Arg Ile 
        355                 360                 365             


Lys Thr Ala Tyr Leu Cys Glu Tyr Leu Trp Lys Asn Phe Cys Ser Tyr 
    370                 375                 380                 


Val Ala Leu Lys Tyr Val Asp Leu Gly Lys Gly Val Tyr His Phe Thr 
385                 390                 395                 400 


Met Ser Asp Lys Leu Ser Leu Met Asn Lys Asn Thr Asn Glu Asn Gly 
                405                 410                 415     


Ile Lys Phe Gly Glu Val Asp Ser Arg Phe Asn Lys Gly Ile Ser Ser 
            420                 425                 430         


Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Thr Ile Asp Arg Asn Ile 
        435                 440                 445             


Ser Thr Tyr Thr Thr Phe Ala Thr Asn Ile Phe Ala Lys Ser Val Ile 
    450                 455                 460                 


Lys Asp Ser Tyr Arg Gln Lys Lys Ala Gly Asn Ser Asp Ala Leu Gln 
465                 470                 475                 480 


Tyr Asp Asp Glu Thr Tyr Tyr Asn Arg Lys Ala Met Asn Pro Tyr Ala 
                485                 490                 495     


Leu Lys Arg Val Leu Arg Tyr Trp Gly Gly Gln Ser Arg Trp Lys Ser 
            500                 505                 510         


Glu Leu Glu Glu Leu Asn Val Ala Glu Leu Cys Ile Asp Ile Lys Asn 
        515                 520                 525             


Arg Leu Ser Lys Ile Arg Asn Ser Gly Val His Tyr Thr Ser Thr Ser 
    530                 535                 540                 


Ala Leu Lys Gly Asn Asp Asp Asp Ser Ile Val Gly Met Leu Ile Lys 
545                 550                 555                 560 


Lys Asp Phe Asp Asp Ile Lys Asp Val Tyr Ala Ser Lys Tyr Tyr Ser 
                565                 570                 575     


Asn Asn Val Trp Met Phe Tyr Asn Thr Asp Lys Ile Ser Lys Met Met 
            580                 585                 590         


Glu Tyr Leu Tyr Gln Asp Asp Ser Asn Ile Arg Asp Ala Gln Ile Pro 
        595                 600                 605             


Ala Phe Asn Ser Val Ile Lys Arg Lys Asp Met Ala Glu Val Ile Glu 
    610                 615                 620                 


Lys Ile Val Lys Lys Asn Ser Tyr Lys Thr Ile Lys Glu Pro Tyr Gln 
625                 630                 635                 640 


Arg Glu Lys Tyr Arg Ser Cys Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
                645                 650                 655     


Tyr Asn Arg Phe Ile Lys Gln Asp Asn Leu Lys Asp Gln Val Ile Gln 
            660                 665                 670         


Ile Ile Asp Ser Asn Thr Glu Leu Ile Gly Asp Asn Ser Arg Ala Val 
        675                 680                 685             


Asp Asn Leu Lys Lys Arg Ile His Asp Val Asp Ser Gln Thr Met Ser 
    690                 695                 700                 


Phe Gly Glu Leu Cys Gln Val Ile Met Thr Asp Tyr Asn Met Gln Asn 
705                 710                 715                 720 


Gln Glu Asn Lys Ser Ile Lys Ser Lys Glu Arg Gln Asp Lys Asp Arg 
                725                 730                 735     


Lys Asn Gly Ile Asp Asn Ser Tyr Lys His Phe Pro Leu Leu Leu His 
            740                 745                 750         


His Leu Ile Lys Val Ser Phe Leu Lys Phe Ile Lys Thr Asp Glu Lys 
        755                 760                 765             


Leu Ala Phe Ile Arg Glu Pro Arg Ile Thr Glu Trp Asp Lys Thr Leu 
    770                 775                 780                 


Glu Gln Phe Glu Ala Gln Ile Gln Thr Val Asp Ile Tyr Asn Ser Leu 
785                 790                 795                 800 


Lys Met Met Val Ala Glu Asn Lys Ser Leu Leu Asp Trp Tyr Thr Leu 
                805                 810                 815     


Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asp Val 
            820                 825                 830         


Lys Asn Tyr Ile Gln Tyr Leu Ser Asn Ile Asp Lys Arg Ala Gly Ser 
        835                 840                 845             


Val Lys Asn Asn Lys Ser Ala Ser Thr Glu Val Lys Ile Arg Gln Tyr 
    850                 855                 860                 


Ser Glu Ile Val Arg Ile Leu Asp Phe Ser Leu Gln Tyr Ile Gly Arg 
865                 870                 875                 880 


Val Ser Asn Asp Val Thr Asp Tyr Phe Val Asp Glu Asp Glu Tyr Ala 
                885                 890                 895     


Ala Phe Leu Ser Lys Tyr Val Glu Phe Ser Gly Asn Asp Ile Val Ser 
            900                 905                 910         


Met Lys Ala Phe Cys Gln Ser Arg Thr Ala Asn Gly Lys His Thr Ile 
        915                 920                 925             


Gly Leu Tyr Cys Asp Gly Ala Asn Pro Ile Met Asn Arg Asn Ile Ala 
    930                 935                 940                 


Tyr Ala Lys Met Tyr Gly Asn Asp Glu Ile Leu Ser Tyr Ile Tyr Asn 
945                 950                 955                 960 


Lys Val Thr Lys Lys Asp Ile Glu Lys Tyr Tyr Val Ser Gln Asp Asn 
                965                 970                 975     


Leu Glu Lys Val Phe Ala Asp Gly Lys Cys Gln Asp Val Gln Gln Gln 
            980                 985                 990         


Asn Ala Leu Cys Asp Phe Gln Lys  Met Lys Asn His Ile  Glu Leu Thr 
        995                 1000                 1005             


Glu Val  Ser Ile Tyr Thr Asp  Ile Leu Asn Asp Phe  Met Ala Gln 
    1010                 1015                 1020             


Phe Ile  Ser Trp Ala Tyr Leu  Arg Glu Arg Asp Leu  Met Tyr Phe 
    1025                 1030                 1035             


Gln Leu  Gly Leu Asn Tyr Ile  Arg Met Phe Tyr Gly  Thr Tyr Glu 
    1040                 1045                 1050             


Leu Glu  Glu Lys Tyr Tyr Lys  Leu His Gly Glu Asn  Ile Asn Ile 
    1055                 1060                 1065             


Glu Lys  Gly Ala Leu Leu Tyr  Gln Ile Val Ala Met  Tyr Ser His 
    1070                 1075                 1080             


Glu Leu  Pro Ile Tyr Lys Val  Asp Glu Ser Gly Ile  Ala Ile Leu 
    1085                 1090                 1095             


Ala Glu  Lys Gln Gly Ser Ser  Gly Ala Ser Ile Lys  Ser Phe Val 
    1100                 1105                 1110             


Thr Glu  Tyr Cys Lys Glu Glu  Met Lys Lys Ala Tyr  Thr Tyr Glu 
    1115                 1120                 1125             


Asn Gly  Leu Glu Leu Phe Glu  Asp Val Asn Gln His  Asp Asp Leu 
    1130                 1135                 1140             


Ser Lys  Leu Arg Asn Asp Phe  Ala His Met Arg Tyr  Met Ser Ala 
    1145                 1150                 1155             


Arg Asp  Lys Ser Ile Met Asp  Ile Val Ser Glu Ile  Tyr Asn Gly 
    1160                 1165                 1170             


Phe Phe  Ile Tyr Asp Thr Lys  Leu Lys Lys Ser Val  Ser Phe Ile 
    1175                 1180                 1185             


Phe Lys  Asn Ile Leu Met Arg  Tyr Ala Val Asp Val  Asn Ile Glu 
    1190                 1195                 1200             


Phe Cys  His Lys Gly Asp Asn  Glu Asp Thr Asn Asn  Leu Ile Arg 
    1205                 1210                 1215             


Ile Lys  Asp Glu Val Gly Leu  Tyr Ser Asp Lys Tyr  Thr Tyr Lys 
    1220                 1225                 1230             


Val Glu  Asp Asn Asp Thr Val  Asp Ile Glu Val Arg  Asn Ser Glu 
    1235                 1240                 1245             


Phe Leu  Glu Gln Leu Lys Lys  Leu Leu Glu Tyr Lys  Lys Glu Ser 
    1250                 1255                 1260             


Glu Gly  Ser Glu Leu 
    1265             


<210>  476
<211>  1381
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  476

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Gly Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asp 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Leu Leu 
    1355                 1360                 1365             


Gln Thr  Leu Ile Leu Asn Tyr  Gln Ile Lys Tyr Leu  Arg 
    1370                 1375                 1380     


<210>  477
<211>  1508
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  477

Met Ser Lys Ile Tyr Gly Tyr Lys Lys Trp Cys Asn Tyr Lys Glu Glu 
1               5                   10                  15      


Val Arg Ile Glu Leu Gly Arg Thr Glu Arg Pro Lys Ile Lys Asn Asp 
            20                  25                  30          


Glu Glu His Thr Glu Ile Asn Leu Val Val Ile Asp Glu Lys Thr Glu 
        35                  40                  45              


Lys Tyr Lys Ile Asn Phe Asn Asn Lys Glu Val Tyr Leu Lys Ile Leu 
    50                  55                  60                  


Tyr Asn Glu Lys Leu Lys Lys Arg Ile Leu Glu Ile Asp Lys Glu Lys 
65                  70                  75                  80  


Asn Lys Asn Arg Ser Ile Lys Leu Asn Tyr Asp Lys Glu Thr Lys Asp 
                85                  90                  95      


Tyr Ile Leu Ile Phe Asp Asn Lys Lys Ile Arg Val Lys Arg Glu Tyr 
            100                 105                 110         


Ile Thr Lys Asn Asn Asn Glu Ile Pro Asp Asn Thr Asp Thr Lys Glu 
        115                 120                 125             


Lys Asn Lys Tyr Ile Val Lys Ser Lys Arg Asp Glu Asp Lys Ile Lys 
    130                 135                 140                 


Ile Thr Asn Ser Lys Phe Ile Glu Lys Leu Ile Glu Tyr Lys Thr Glu 
145                 150                 155                 160 


Asn Asn Ile Gln Lys Asp Phe Asn Arg Lys Phe His Met Gly Asn Ile 
                165                 170                 175     


Leu Phe Lys Leu Lys Lys Glu Asn Ile Leu Ile Lys Gly Glu Asp Ile 
            180                 185                 190         


Val Asp Glu Ile Glu Val Leu Ser Arg Thr Glu Asn Leu Ser Lys Lys 
        195                 200                 205             


Ile Thr Arg Lys Lys Leu Lys Glu Gln Leu Lys Lys Gln Leu Asp Lys 
    210                 215                 220                 


Gly Lys Leu Lys Glu Asn Ser Lys Glu Ile Tyr Leu Thr Ile Lys Asn 
225                 230                 235                 240 


Glu Asn Ile Lys Ile Lys Leu Glu Tyr Asn Lys Thr Lys Phe Asp Arg 
                245                 250                 255     


Asn Lys Glu Glu Tyr Ile Leu Ser Trp Lys Lys Ile Asp Glu Lys Glu 
            260                 265                 270         


Arg Gln Ala Lys Ile Glu Val Tyr Arg Lys Phe Gln Asn Ile Asn Glu 
        275                 280                 285             


Lys Phe Tyr Tyr Leu Ile Glu Asn Phe Val Asn Glu Glu Gln Gly Glu 
    290                 295                 300                 


Val Lys Asn Leu Lys Lys Arg Tyr Phe Arg Asp Tyr Ile Glu Ile Leu 
305                 310                 315                 320 


Phe Leu Glu Lys Glu Glu Glu Tyr Gly Lys Ile Val Glu His Ile Glu 
                325                 330                 335     


Glu Ile Lys Lys Lys Asn Ser Glu Asn Lys Lys Trp Asn Ile Asp Lys 
            340                 345                 350         


Phe Val Glu Phe Tyr Ser Asn Val Gly Gly Lys Lys Ala Thr Glu Asn 
        355                 360                 365             


Lys Lys Ile Phe Val Asn Lys Ile Leu Asn Tyr Ile Cys Asn Ser Val 
    370                 375                 380                 


Lys Leu Thr Lys Glu Asp Ile Val Asp Tyr Ile Ile Gly Glu Leu Lys 
385                 390                 395                 400 


Tyr Trp Asp Ile Ala Lys Arg Val Glu Leu Lys Lys Lys Glu Thr Gln 
                405                 410                 415     


Asp Met Pro Lys Glu Lys Ile Glu Lys Ala Arg Ile Lys Thr Tyr Val 
            420                 425                 430         


Glu Met Asp Lys His Glu Lys Phe Lys Glu Lys Gly Lys Glu Lys Asn 
        435                 440                 445             


Glu Ile Val Lys Leu Phe Ile Lys Asp Ile Glu Ser Lys Val Ile Arg 
    450                 455                 460                 


Asn Lys Ile Glu Lys Ile Leu Lys Glu Phe Lys Ile Glu Lys Leu Val 
465                 470                 475                 480 


Asn Asp Leu Lys Asp Lys Ile Lys Glu Glu Glu Asn Phe Asp Thr Glu 
                485                 490                 495     


Ile Phe Gly Leu Tyr Lys Gly His Tyr Lys Ser Ile Phe Lys Lys Asp 
            500                 505                 510         


Gly Asn Ile Glu Val Ile Gly Asp Asn Phe Glu Phe Glu Lys Met Pro 
        515                 520                 525             


Cys Asn Glu Lys Glu Leu Tyr Lys Ile Ile Tyr Arg Tyr Ile Lys Gly 
    530                 535                 540                 


Arg Ile Glu Lys Ile Leu Ile Asn Arg Arg Glu Ile Arg Glu Asn Ser 
545                 550                 555                 560 


Leu Lys Ile Glu Lys Ile Leu Asn Phe Asp Ser Leu Leu Asn Lys Ile 
                565                 570                 575     


Glu Lys Arg Val Lys Gln Tyr Thr Leu Glu His Ile Met Tyr Leu Gly 
            580                 585                 590         


Lys Ile Lys His Asn Asn Ile Asp Met Thr Lys Val Asn Thr Asn Asp 
        595                 600                 605             


Phe Ser Lys Leu His Ala Lys Glu Glu Leu Asp Leu Glu Leu Ile Ala 
    610                 615                 620                 


Phe Phe Ala Ala Thr Asn Met Glu Leu Asn Lys Ile Phe Ser Lys Lys 
625                 630                 635                 640 


Asn Ala Glu Gly Thr Glu Asn Ile Asp Phe Phe Gly Gly Asp Arg Glu 
                645                 650                 655     


Arg Asp Tyr Ile Leu Asp Lys Lys Ile Ser Asn Ser Lys Leu Lys Ile 
            660                 665                 670         


Met Arg Asp Leu Lys Phe Leu Asp Asp Lys Asn Glu Ile Thr Glu Asn 
        675                 680                 685             


Phe Lys Ser Lys Phe Ile Lys Ile Gly Thr Asn Glu Arg Asn Lys Ile 
    690                 695                 700                 


Leu His Ala Asn Asp Lys Arg Arg Asn Gln Lys Glu Ile Leu Glu Asn 
705                 710                 715                 720 


Asp Asn Asp Asp Lys Thr Arg Asp Gln Lys Gly Thr Leu Glu Asp Tyr 
                725                 730                 735     


Asn Lys Val Val Ser Ile Ile Gln Asn Leu Lys Ile Ser Asn Glu Glu 
            740                 745                 750         


Ile Ser Lys Ala Leu Asn Leu Asp Val Val Phe Lys Gly Lys Glu Lys 
        755                 760                 765             


Ile Ile Ser Lys Ile Asn Asn Ile Asp Ile Ser Lys Glu Asn Asn Lys 
    770                 775                 780                 


Ile Ile Lys Phe Leu Pro Ser Phe Ser Lys Val Leu Pro Glu Ile Leu 
785                 790                 795                 800 


Asn Leu Tyr Lys Lys Met Asn Lys Asn Asn Pro Phe Asp Thr Ile Glu 
                805                 810                 815     


Thr Glu Arg Ile Ile Arg Asn Ala Leu Ile Tyr Ile Asn Lys Glu Leu 
            820                 825                 830         


Tyr Lys Lys Leu Ile Leu Glu Lys Asp Leu Gly Lys Glu Asn Asn Lys 
        835                 840                 845             


Tyr Lys Phe Leu Lys Glu Leu Lys Lys Thr Leu Ser Gly Thr Asp Glu 
    850                 855                 860                 


Val Asp Lys Pro Ile Ile Glu Asn Tyr Tyr Lys Asn Ser Gln Ile Leu 
865                 870                 875                 880 


Ala Ser Lys Gly Asn Asn Lys Ala Ile Lys Lys Tyr Gln Lys Lys Val 
                885                 890                 895     


Ile Glu Cys Tyr Ile Glu Tyr Leu Lys Lys Asn Tyr Lys Glu Ile Phe 
            900                 905                 910         


Asp Phe Ser Asn Phe Asn Met Asp Ile Lys Lys Ile Lys Gln Lys Ile 
        915                 920                 925             


Lys Asp Ile Asn Asp Asn Lys Thr Tyr Arg Arg Lys Val Ile Ile Lys 
    930                 935                 940                 


Ser Asp Asn Lys Ser Ile Glu Ile Lys Asn Asp Phe Glu Tyr Ile Ile 
945                 950                 955                 960 


Ser Ile Phe Ala Leu Leu Asn Asn Asn Val Val Ile Asn Lys Ile Arg 
                965                 970                 975     


Asn Arg Leu Phe Ala Ile Ser Val Trp Leu Asp Arg Gln Glu Tyr Gln 
            980                 985                 990         


Asn Ile Ile Glu Val Leu Asp Glu  Ile Met Gln Ile Asn  Thr Leu Lys 
        995                 1000                 1005             


Thr Glu  Trp Ile Thr Glu Asn  Trp Lys Leu Asp Leu  Lys Lys Phe 
    1010                 1015                 1020             


Ile Glu  Lys Met Glu Leu Ile  Glu Glu Glu Phe Leu  Leu Thr Lys 
    1025                 1030                 1035             


Arg Glu  Phe Phe Gly Lys Tyr  Tyr Glu Asp Ile Lys  Glu Asn Ile 
    1040                 1045                 1050             


Lys Ser  Lys Phe Ile Asn Asp  Tyr Glu Ile Lys Lys  Ile Leu Asp 
    1055                 1060                 1065             


Arg Lys  Phe Asn Gln Ile Val  Asn Phe Glu Asp Asp  Thr Lys Ile 
    1070                 1075                 1080             


Lys Ile  Lys Ala Asp Asn Leu  Asp Arg Asn Glu Lys  Lys Ile Leu 
    1085                 1090                 1095             


Met Pro  Lys Ile Asn Pro Lys  Asn Leu Asn Ser Val  Asp Ile Ile 
    1100                 1105                 1110             


Ser Glu  Ile Asp Lys Phe Ile  Glu Lys Ile Lys Asn  Arg Lys Ala 
    1115                 1120                 1125             


Leu Lys  Leu Ile Phe Asn Ser  Lys Phe Leu Lys Lys  Tyr Lys Glu 
    1130                 1135                 1140             


Ile Ile  Asp Asn Leu Ile Glu  Asn Glu Asp Lys Phe  Glu Lys Val 
    1145                 1150                 1155             


Tyr Tyr  Pro Glu Lys Asn Lys  Asn Glu Leu Tyr Ile  Tyr Lys Lys 
    1160                 1165                 1170             


Asn Leu  Phe Leu Asn Ile Gly  Asn Pro Asn Phe Asp  Asn Ile Tyr 
    1175                 1180                 1185             


Glu Leu  Ile Ser Glu Asp Ile  Lys Val Val Asp Thr  Lys Val Leu 
    1190                 1195                 1200             


Phe Asp  Asn Asn Ile Arg Asn  Asn Glu Ile Phe Glu  Ile Asp Glu 
    1205                 1210                 1215             


Ile Leu  Lys Tyr Leu Asn Asn  Lys Leu Asn Gly Tyr  Ser Lys Glu 
    1220                 1225                 1230             


Tyr Lys  Glu Lys Tyr Lys Asp  Lys Leu Glu Gln Asn  Ser Cys Phe 
    1235                 1240                 1245             


Phe Ile  Gln Asn Ile Lys His  Lys Lys Tyr Glu Ser  Phe Glu Lys 
    1250                 1255                 1260             


Leu Lys  Glu Asn Tyr Asn Glu  Val Ser Glu Tyr Lys  Arg Val Arg 
    1265                 1270                 1275             


Asp Leu  Val Glu Phe Asn Tyr  Leu Asn Lys Ile Glu  Ser Tyr Leu 
    1280                 1285                 1290             


Ile Asp  Ile Asn Trp Lys Leu  Ala Ile Gln Met Ala  Arg Phe Glu 
    1295                 1300                 1305             


Arg Asp  Met His Tyr Ile Val  Asn Gly Leu Asn Tyr  Leu Asp Ile 
    1310                 1315                 1320             


Ile Glu  Leu Glu Asn Asn Arg  Asn Glu Asn Arg Ser  Ser Pro Tyr 
    1325                 1330                 1335             


Pro Lys  Tyr Lys Tyr Ile Asp  Lys Asn Asp Lys Thr  Lys Gly Arg 
    1340                 1345                 1350             


Glu Leu  Asp Phe Ala Thr Ser  Tyr Tyr Asn Phe Lys  Asp Tyr Pro 
    1355                 1360                 1365             


Lys Leu  Val Lys Ile Cys Leu  Lys Phe Gly Ile Asn  Leu Ser Glu 
    1370                 1375                 1380             


Asn Ser  Glu Ile Asn Lys Pro  Glu Lys Lys Ser Ile  Arg Asn Tyr 
    1385                 1390                 1395             


Ile Ser  His Phe Tyr Ile Ile  Arg Glu Pro Phe Lys  Lys Tyr Ser 
    1400                 1405                 1410             


Ile Ala  Glu Gln Ile Asp Lys  Val Ser Glu Val Met  Glu Tyr Ser 
    1415                 1420                 1425             


Thr Arg  Tyr Asn Asn Ser Thr  Tyr Asn Ser Val Phe  Glu Val Phe 
    1430                 1435                 1440             


Lys Lys  Asp Val Asp Leu Asn  Tyr Asn Asn Leu Lys  Arg Lys Phe 
    1445                 1450                 1455             


Arg Leu  Ser Asp Asn Cys Pro  Asp Asn Ser Lys Thr  Leu Phe Glu 
    1460                 1465                 1470             


Ile Lys  Asn Leu Ile Asn Pro  Lys Lys Val Ser Val  Leu Glu Leu 
    1475                 1480                 1485             


Glu His  Tyr Asn Ser Glu Tyr  Val Val Lys Leu Ile  Glu Lys Ile 
    1490                 1495                 1500             


Leu Thr  Lys Lys Leu 
    1505             


<210>  478
<211>  1370
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  478

Val Lys Lys Asn Ile Leu Glu Val Asp Gln Ile Lys Ser Lys Ile Glu 
1               5                   10                  15      


Asn Ser Gln Lys Leu Glu Leu Lys Glu Lys Thr Lys Lys Glu Ser Glu 
            20                  25                  30          


Asp Lys Ala Gly Glu Asp Asp Arg Leu Glu Gln Ile Leu Ser Ser Cys 
        35                  40                  45              


Leu Lys Lys Ser Leu Arg Asn Tyr Ser Asn Glu Leu Ala Val Val Ile 
    50                  55                  60                  


Asn Ser Leu Arg Lys Lys Gln Val Asp Glu Glu Glu Leu Asp Gln Ala 
65                  70                  75                  80  


Ile Ser Thr Leu Arg Glu Val Leu Ser Lys Asp Ile Arg Arg Lys Thr 
                85                  90                  95      


Thr Lys Glu Asn Ile Lys Lys Ser Ile Glu Asn Gln Asn Leu Val Val 
            100                 105                 110         


Gln Pro Glu Ser Ile Lys Asp Asp Ser Asp Lys Val Phe Ile Leu Ser 
        115                 120                 125             


Lys Ser Phe Lys Arg Glu Ser Asp Ser Ser Arg Asn Asn Lys Glu Lys 
    130                 135                 140                 


Lys Gly Leu Ala Ala Phe Leu Asn Gln Tyr Ala Thr Leu Asp Lys Lys 
145                 150                 155                 160 


Thr Arg Asp Gln Tyr Leu Lys Lys Ile Arg Cys Ile Ile Asp Ile Tyr 
                165                 170                 175     


Phe Ser Val Pro Glu Lys Ala Ala Asn Asp Ser Lys Asn Ile Val Asp 
            180                 185                 190         


Val Asp Ile Ile Glu Ala Ile Glu Lys Ser Glu Leu Ser Glu Arg Leu 
        195                 200                 205             


Lys Lys Ile Ser Asp Asn Glu Ile Asn Val Trp Lys Asp His Val Glu 
    210                 215                 220                 


Ala Lys Gly Asn Asn Ile Tyr Phe Val Lys Leu Thr Asp His Ile Lys 
225                 230                 235                 240 


Glu Ile Ile Ser Asp Ser Glu Asn Gln Lys Asp Ala Ala Ser Thr His 
                245                 250                 255     


Asp Glu Asn Leu Ser Ser Val Leu Asp Lys Lys Asn Asn Arg Thr Leu 
            260                 265                 270         


Ser Lys Asp Glu Val Asn Phe Leu Arg Asp Asp Ile Arg Cys Ile Asn 
        275                 280                 285             


Ala Ala Ser Tyr Arg Ile Ser Thr Lys Ile Ile Asn Lys Tyr Ala Asp 
    290                 295                 300                 


Ser Gly Leu Phe Phe Asp Asp Gly Lys Ile Asn Ser Tyr Ile Ile His 
305                 310                 315                 320 


His Ile Glu Asn Ala Val Glu Arg Ile Leu Asp Gly Ile Gly Ser Tyr 
                325                 330                 335     


Thr Leu Phe Lys Leu Arg Leu Gly Tyr Leu Ser Glu Lys Val Trp Lys 
            340                 345                 350         


Asp Ile Leu Asn Leu Ile Ser Ile Lys Tyr Ile Ala Ile Gly Lys Ala 
        355                 360                 365             


Val Tyr Asn Phe Ala Val Glu Asp Ala Phe Asp Asp Thr Lys Thr Glu 
    370                 375                 380                 


Lys Asn Leu Gly Arg Ile Ser Glu Asn Val Lys Asn Gly Ile Ser Ser 
385                 390                 395                 400 


Phe Asp Tyr Glu Ile Ile Lys Ala Asn Glu Thr Leu Gln Arg Glu Val 
                405                 410                 415     


Ala Val Asp Val Thr Phe Ala Ala Asn Asn Phe Ser Arg Ala Thr Val 
            420                 425                 430         


Asp Ile Asp Tyr Ser Ile Asp Lys Glu Glu Asp Phe Leu Leu Trp Lys 
        435                 440                 445             


Ile Asn Gln Val Lys Ser Asn Leu Lys His Thr Glu Asp Met Asn Asp 
    450                 455                 460                 


Glu Asp Leu Ala Leu Thr His Val Leu Gln Phe Phe Gly Gly Arg Ser 
465                 470                 475                 480 


Ser Trp His Ala Leu Glu Asp Ser Tyr Lys Asn Tyr Lys Arg Gln Glu 
                485                 490                 495     


Lys Asp Val Ile Phe Asp Tyr Gly Thr Ser Leu Val Tyr Asp Ile Lys 
            500                 505                 510         


Asn Ile Leu Tyr Glu Met Arg Asn Glu Thr Phe His Phe Asn Thr Leu 
        515                 520                 525             


Asn Asn Asn Ile Gly Asp Trp Asn Arg Asp Leu Val Ser Lys Met Phe 
    530                 535                 540                 


Ser Cys Glu Val Asp Tyr Phe Phe Asp Val Glu Lys Asn Lys Met Tyr 
545                 550                 555                 560 


Ser Asn Asn Leu Pro Met Phe Tyr Asn Gln Asp Lys Leu Lys Gly Leu 
                565                 570                 575     


Ile Asp Phe Leu Tyr His Lys Glu Val Pro Arg Met Ala Gln Val Pro 
            580                 585                 590         


Ser Phe Asn Thr Val Phe Val Arg Lys Asn Phe Pro Asp Phe Leu Gln 
        595                 600                 605             


Asn Glu Leu His Leu Lys Pro Lys Asn Ile Leu Thr Asp Ala Glu Thr 
    610                 615                 620                 


Met Leu Lys Trp Glu Asn Ala Leu Tyr Tyr Ala Phe Lys Gln Ile Tyr 
625                 630                 635                 640 


Tyr His Val Phe Phe Asp Gly Ala Asn Asp Lys Glu Ser Asp Ile Lys 
                645                 650                 655     


Asn Met Phe Ile Lys Thr Leu Ser Glu Leu Asn Glu Tyr Gly Asp Gly 
            660                 665                 670         


Val Asn Lys Glu Ala Val Ser Asp Phe Tyr Glu Arg Val Ile Ala Leu 
        675                 680                 685             


Lys Asp Lys Met Ser Phe Ala Glu Ile Cys Gln Asn Ile Met Ser Glu 
    690                 695                 700                 


Tyr Asn Leu Gln Asn Ser Arg Asp Arg Arg His Lys Ser Ser Arg Asp 
705                 710                 715                 720 


Ala Ile Lys Asn Pro Asp Ile Phe Gln His Tyr Lys Leu Leu Leu Asn 
                725                 730                 735     


Val Val Ile Gln Lys Ala Phe Ala Lys Phe Leu Asn Lys Glu Lys Ser 
            740                 745                 750         


Asn Thr Asn Ser Arg Ile Gly Phe Leu Leu Asp Asn Asn Ile Arg Val 
        755                 760                 765             


Asn Asp Met Met Pro Val Glu Lys Phe Cys Pro Asn Trp Arg Ser Gly 
    770                 775                 780                 


Ile Phe Asp Ser Leu Lys Ser Gln Val Ser Asn Asp Ile Glu Leu Gln 
785                 790                 795                 800 


Lys Trp Tyr Val Phe Gly Arg Leu Leu Asp Gly Lys Ile Ile Asn Gln 
                805                 810                 815     


Leu Ile Gly Ser Ile Arg Ser Tyr Ile Gln Tyr Glu Gln Asp Val Arg 
            820                 825                 830         


Lys Arg Ala Glu Asn Val Gly Val Lys Val Ile Arg Tyr Asp Lys Ser 
        835                 840                 845             


Thr Ile Glu Lys Phe Gln Gln Ile Leu Lys Ala Leu Glu Val Cys Val 
    850                 855                 860                 


Asn Leu Ser Gly Lys Phe Ser Asn Asp Tyr Thr Asp Tyr Phe Ser Ser 
865                 870                 875                 880 


Lys Glu Glu Tyr Ala Glu Tyr Leu Ser His Phe Leu Lys Tyr Glu Asn 
                885                 890                 895     


Ser Lys Gly Gln Cys Trp Glu Asn Leu Val Lys Phe Cys Glu Gly Leu 
            900                 905                 910         


Asp Asp Ala Lys Ile Tyr Leu Asp Ala Lys Asn Pro Ile Asn Asn Arg 
        915                 920                 925             


Asn Ile Ile Met Ser Lys Leu Tyr Gly Pro Tyr Glu Ile Ile Gly Asn 
    930                 935                 940                 


Val Leu Glu Ala Asn Asn Gly Arg Ile Thr Asn Asp Asp Leu Lys Glu 
945                 950                 955                 960 


Tyr Ser Lys His Ala Lys Glu Ile Asp Glu Tyr Arg Val Arg Gly Lys 
                965                 970                 975     


Ala Arg Asn Ile Thr Glu Gln Arg Ser Ile Asn Lys Phe Gln Arg Leu 
            980                 985                 990         


Lys Asn Arg Val Glu Leu Arg Asn  Ile Thr Glu Tyr Gly  Glu Leu Ile 
        995                 1000                 1005             


Asn Glu  Leu Leu Gly Gln Met  Val Asp Trp Ser Tyr  Leu Arg Glu 
    1010                 1015                 1020             


Arg Asp  Leu Leu Tyr Phe Gln  Leu Gly Phe His Tyr  Ser Cys Leu 
    1025                 1030                 1035             


Gln Asn  Asp Ser Ser Lys Pro  Lys Gly Tyr Lys Val  Ile Lys Ser 
    1040                 1045                 1050             


Gly Asn  Thr Glu Val Lys Gly  Ala Ile Leu Tyr Gln  Ile Leu Ser 
    1055                 1060                 1065             


Met Tyr  Ile Asn Gly Ile Ser  Ile Phe Glu Val Asp  Lys Lys Gly 
    1070                 1075                 1080             


Asn Phe  Val Gln Ser Glu Lys  Ser Leu Ser Thr Gly  Gly Gln Ile 
    1085                 1090                 1095             


Arg Ile  Phe Tyr Lys Tyr Cys  Gly Phe Ile Leu Asp  Lys Lys Asn 
    1100                 1105                 1110             


Asp Lys  Glu Lys Tyr Tyr Asp  Glu Thr Ile Tyr Asn  Ser Gly Leu 
    1115                 1120                 1125             


Glu Val  Phe Glu Asn Ile Asn  Glu His Glu Asn Ile  Ile Asn Leu 
    1130                 1135                 1140             


Arg Asn  Ala Ile Asp His Met  Lys Tyr Tyr Ser Leu  Ser Lys Glu 
    1145                 1150                 1155             


Lys Lys  Asp Glu Lys Asp Cys  Phe Thr Tyr Arg Ala  Tyr Gly Ile 
    1160                 1165                 1170             


Leu Asp  Tyr Tyr Ser Glu Ile  Phe Asp Arg Phe Phe  Thr Tyr Asp 
    1175                 1180                 1185             


Met Arg  Tyr Lys Asn Asn Val  Pro Asn Met Leu Lys  Asn Ile Leu 
    1190                 1195                 1200             


Met Arg  His Phe Ile Val Met  Tyr Pro Val Phe Asp  Glu Asn Gly 
    1205                 1210                 1215             


Asn Lys  Lys Ala Ala Gly Ser  Gln Asn Thr Lys Asn  Cys Ala Ser 
    1220                 1225                 1230             


Ile Gly  Val Gln Lys Asn Gly  Phe Glu Ser Asp Tyr  Phe Thr Tyr 
    1235                 1240                 1245             


Lys Phe  Ile Asn Gln Asn Asn  Gln Gln Tyr Glu Gln  Ile Asp Thr 
    1250                 1255                 1260             


Ala Arg  Asp Phe Asp Phe Leu  Lys Ile Val Leu Ala  Ile Leu Tyr 
    1265                 1270                 1275             


Tyr Pro  His Ala Ile Ser Glu  Gly Leu Ile Lys Asn  Gln Asp Asp 
    1280                 1285                 1290             


Phe Ile  Lys Lys Gln Asn Asp  Lys Phe Leu Lys Thr  Ala Glu Lys 
    1295                 1300                 1305             


Lys Gln  Gly Asn Asn Ser Ile  His Lys Gln Asn Gln  Asn Lys Arg 
    1310                 1315                 1320             


Ser Gly  Tyr Pro Tyr Val Ala  Thr Asp Ser Lys Gln  Arg Lys Asn 
    1325                 1330                 1335             


Asp Tyr  Lys Asn Asn Lys Ser  Lys Gly Asn His Glu  Asp Asp Asn 
    1340                 1345                 1350             


Asn Cys  Thr Thr Gly Leu Gly  Ser Leu Leu Lys Gly  Ile Lys Leu 
    1355                 1360                 1365             


Asp Asn  
    1370 


<210>  479
<211>  1287
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  479

Met Arg Ile Gly Lys Val Gln Gly Arg Thr Phe Thr Gly Phe Asp Asn 
1               5                   10                  15      


Ala Arg Gly Lys Thr Leu Arg Arg Arg Leu Leu Thr Arg Pro Asp Asn 
            20                  25                  30          


Glu Ala Arg Ser Leu Ser Glu His Leu Ala His Asp Pro Lys Ala Leu 
        35                  40                  45              


Ile Gly Gln Ala Ile Ser Arg Ile Asp Thr Ile Tyr Gln Lys Pro Lys 
    50                  55                  60                  


Thr Gly Lys Pro Thr Pro Glu Gln Phe Gly His Arg Asp Thr Leu Gly 
65                  70                  75                  80  


Trp Ala Tyr Trp Lys Leu Leu Val Ala Ser Tyr Pro Glu Val Glu Gly 
                85                  90                  95      


His Arg Asp Leu Phe Val Arg Arg Leu His Pro Tyr Gly Asp Thr Pro 
            100                 105                 110         


Pro Lys Ser His Gly Gln Lys Glu Gly Glu His Gln Lys Gly Gly Lys 
        115                 120                 125             


Pro Gln Leu Glu Gly Arg Trp His Gly Val Met Ala Gln His Gly Lys 
    130                 135                 140                 


Asn Pro Asp Gln Ile Ala Ala Arg Leu Phe Asp His Leu His Asn Ser 
145                 150                 155                 160 


Glu Leu Arg Phe Gly Gly Thr Ala Ser Gly Glu Pro Arg Thr Arg Pro 
                165                 170                 175     


Gly Lys Glu Ala Thr Pro Thr Gly Leu Ile Gly Ala Arg Ala Lys Thr 
            180                 185                 190         


Ile Glu His Ser Val Leu Pro Arg Asp Ala Lys Arg Phe Val Ala Glu 
        195                 200                 205             


Trp Arg Gly Glu Asp Gln Glu Arg Tyr Ala Gly Ala Arg Asp Ile Ala 
    210                 215                 220                 


Ala Ala Ile Ser Ala Gly Leu Asn Asp Lys Asp Gln Lys Ser Gly Ser 
225                 230                 235                 240 


Gly Arg Lys Ser Ala Val Ile Gly Lys Leu Leu Ser Asp His Leu Glu 
                245                 250                 255     


Thr Leu Thr Gly Asn Arg Lys Cys Arg Phe Asp Pro Lys Ser Thr Ala 
            260                 265                 270         


Glu Thr Leu Glu Leu Arg Asp Gly Glu Ser Val Asp Asp Arg Arg Arg 
        275                 280                 285             


Ile Leu Glu Leu His Ala Glu Val Lys Ala Thr Tyr Lys Arg Met Ala 
    290                 295                 300                 


Ala Trp Lys Pro Ala Lys Leu Pro Arg Asn Ser Asp Glu Leu Phe Arg 
305                 310                 315                 320 


Leu Val Arg Gln Gln Ala Asp Asn Arg Ile Leu Asn His Leu Val Arg 
                325                 330                 335     


Val Gly Arg Ile Ser Val Tyr Ser Glu Gln Ser Asp Ala Leu Ser Glu 
            340                 345                 350         


Ser Gln Phe Trp Thr Ser Gly Gly Gln Thr Gln Ile Lys Glu Ser Glu 
        355                 360                 365             


Val Phe Ala Arg Leu Trp Ile Gly Ala Ile Ser Arg Ala Ser Tyr Ser 
    370                 375                 380                 


Met Lys Ala Trp Leu Glu Pro Glu Gly Thr Val Phe Asn Pro Ser Ile 
385                 390                 395                 400 


Asn Asp Phe Asp Val Thr Ser Ser His Asn Thr Asn Arg Ile Leu Glu 
                405                 410                 415     


Asp Ser Gly Arg Leu Ser Asn Ala Met Ala Arg Arg Ala Ile Tyr Phe 
            420                 425                 430         


Gly Glu Thr Pro Glu Phe Asp Ala Leu Gly Glu Glu Asp Gln Arg Val 
        435                 440                 445             


Leu Val Lys Lys Cys Leu Asp Ala Leu Ser Ala Cys Arg Asn Arg Thr 
    450                 455                 460                 


Phe His His Gly Gln Arg Ala Lys Phe Leu Lys Glu Val Arg Lys Gly 
465                 470                 475                 480 


Leu Lys Glu Lys Glu Ala Asp Ser Ala Gly Pro Ala Ala Trp Glu Gly 
                485                 490                 495     


Ile Arg Glu Val Ile Gln Ala Asp Ala Arg Asn Leu Gly Ala Arg Leu 
            500                 505                 510         


Leu Gln Asp Leu Thr Gly Ala Lys Val His Ser Phe Ala Thr Asp Pro 
        515                 520                 525             


Glu Phe Arg His Leu Tyr Glu Ser Val Ala Ala Thr Leu Thr Ala Gly 
    530                 535                 540                 


Gly Glu Leu Glu Ala Ala Leu Pro Arg Leu Lys Asn Val Leu Lys Arg 
545                 550                 555                 560 


Ala Glu Gly Val Arg Cys Tyr Leu Asp Thr Pro Ser Gln Arg Arg Glu 
                565                 570                 575     


Gly Asp Glu Ser Leu Ile Ala Arg Leu Pro Val Ala Pro Val Pro Arg 
            580                 585                 590         


Glu Leu Asp Asp Ala Ala Thr Lys Ala Arg His Ser Ala Leu Leu Arg 
        595                 600                 605             


Leu Tyr Asp Gly Pro Phe Arg Pro Trp Ala Thr Glu Leu Arg Gly Glu 
    610                 615                 620                 


Arg Leu Ser Asp Tyr Ala Ala Arg Ala Lys Arg Leu Ala Thr Arg Leu 
625                 630                 635                 640 


Ala Lys Ser Thr Asn Thr Ala Ser Pro Tyr Pro Asp Ser Val Glu Gly 
                645                 650                 655     


Arg Ser Val Arg Leu Arg Asp Pro Ile Thr Ala Asp Thr Ala Pro Glu 
            660                 665                 670         


Thr Leu Lys Thr Tyr Leu Ser Ala Leu Thr Ala Glu Thr Ala Thr Glu 
        675                 680                 685             


Phe Arg Val Gln Lys Gly Tyr Glu Ser Asp Gly Glu Lys Ala Lys Glu 
    690                 695                 700                 


Gln Ala Glu Phe Ile Glu Asp Phe Arg Arg Asp Met Ile Ala Leu Ala 
705                 710                 715                 720 


Phe Gln Asp Phe Ile Arg Asp His Gly Phe Ala Trp Leu Leu Asp Ile 
                725                 730                 735     


Ala Ser Lys Ala Glu Pro Ser Asn Asp Ala Pro Asn Leu Pro Asp Pro 
            740                 745                 750         


Val Asp Thr Gly Lys Asp Thr Val Phe Glu Asp Trp Gln Ala Leu Leu 
        755                 760                 765             


Tyr Leu Phe Leu His Phe Val Pro Ala Asp Asp Val Ser Gln Leu Leu 
    770                 775                 780                 


His Gln Leu Arg Lys Trp Asp Ala Leu Gln Asp Lys Tyr Glu Leu Ala 
785                 790                 795                 800 


Glu Pro Gly Glu Thr Leu Gly Gln Thr Lys Ala Asp Thr Arg Lys Ile 
                805                 810                 815     


Val Gly Gln Phe Arg Asp Cys Leu Thr Leu Phe Leu Lys Thr Gly Asp 
            820                 825                 830         


Ala Arg Phe Asp Gly Glu Gly Val Glu Leu Pro Leu Ser Asp Phe Gln 
        835                 840                 845             


Glu Leu Phe Glu Ser Pro Ala Thr Phe Lys Glu Leu Phe Leu Ala Glu 
    850                 855                 860                 


Pro Ala Glu Asn Asp Ala Ser Glu Thr Asp Asp Gln Asp Ala Pro Gly 
865                 870                 875                 880 


Glu Lys His Arg Val Thr Arg Thr Arg Arg Gly Leu Arg Gln Ile Leu 
                885                 890                 895     


Arg Tyr Asn His Met Pro Val Leu Arg Asp Leu Phe Leu Ala His Lys 
            900                 905                 910         


Val Thr Asp Ala Glu Val Asp Gly Leu Gln Ala Leu Glu Val Asp Asp 
        915                 920                 925             


Pro Gln Thr Gly Glu Ser Gln Ile Gly Ala Ala Gln Arg Ile Arg Thr 
    930                 935                 940                 


Glu Ile His His His Thr Ser Asn Asp Lys Gln Ile Ser Glu Ala Lys 
945                 950                 955                 960 


Val Glu Glu Tyr Arg Arg Ala Leu Ser Thr Ile Glu Arg His Arg Phe 
                965                 970                 975     


Leu Val Gly Arg Val Tyr Leu Gly Asp His Ile Arg Val His Lys Leu 
            980                 985                 990         


Met Met Asp Val Met Gly Arg Leu  Val Asp Phe Ala Gly  Ala Trp Glu 
        995                 1000                 1005             


Arg Glu  Ala Ala Asp Gly Asp  Arg Lys Gly Phe Ile  Ser Arg Ala 
    1010                 1015                 1020             


Ile Ala  Leu Pro Glu Val Ala  Glu Gly Tyr Ala Ala  Asp Arg Leu 
    1025                 1030                 1035             


Lys Thr  Val Ala Arg Arg Val  Leu Asp Asp Gly Glu  Ala Arg Arg 
    1040                 1045                 1050             


Ile Arg  Asn Asp Leu Gly His  Phe Asn Asp Leu Ala  Pro Thr Ser 
    1055                 1060                 1065             


Gly Pro  Ala Asn Leu Thr Phe  Val Val Asn Arg Ala  Arg Arg Met 
    1070                 1075                 1080             


Met Arg  His Asp Arg Lys Arg  Lys Asn Ala Val Thr  Lys Ser Val 
    1085                 1090                 1095             


Ile Glu  Ile Leu Asn Arg Gln  Gly Leu Gly Ile Glu  Trp Thr Met 
    1100                 1105                 1110             


Arg Asn  His Glu Leu Cys Glu  Ala Lys Leu Trp Gln  Asn Pro Val 
    1115                 1120                 1125             


Lys His  Leu Gly Phe Ala Thr  Leu Glu Gly Arg Gly  Lys Lys Trp 
    1130                 1135                 1140             


Arg Arg  Pro Phe Glu Ala Arg  Tyr Gly Asp Ala Tyr  Met Ala Met 
    1145                 1150                 1155             


Val Ala  Gln Leu Phe Asp Gly  Thr Val Thr Ser Pro  Pro Ala Lys 
    1160                 1165                 1170             


Gly Pro  Pro Gln Ser Gly Lys  Ser Gly Gly Lys Pro  Gly Lys Gly 
    1175                 1180                 1185             


Ala Glu  Gly Gly Ala Lys Glu  Lys Ser Arg Ser Pro  Thr Arg Met 
    1190                 1195                 1200             


Glu Glu  Gly Gly Val Tyr Glu  Gly Arg Val Ala Lys  Ala Lys Ser 
    1205                 1210                 1215             


Asp Lys  Gly Phe Gly Phe Leu  Leu Val Glu Gly Ala  Gln Glu Glu 
    1220                 1225                 1230             


Ile Phe  Leu His Ile Tyr Gly  Ile Ser Gly Asn Arg  Pro Ala Arg 
    1235                 1240                 1245             


Ile Glu  Asn Gly Gln Arg Tyr  Arg Phe Thr Leu Gly  Ile Asp Arg 
    1250                 1255                 1260             


Asp Arg  Glu Arg Arg Lys Glu  Arg Ala Trp Val Ala  Arg Glu Ala 
    1265                 1270                 1275             


Val Arg  Ile Asp Glu Asn Arg  Ser Lys 
    1280                 1285         


<210>  480
<211>  1373
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  480

Met Ala Lys His Leu Arg Pro Ile Gly Glu Ser Tyr Thr Asp Phe Leu 
1               5                   10                  15      


Asp Glu Thr Glu Phe Val Arg Leu Gly Arg Gly Leu His Arg Gly His 
            20                  25                  30          


His Gly Val Gln Ile Pro Pro Thr Glu Leu Pro Ser Tyr Leu Ala Glu 
        35                  40                  45              


Tyr Arg Lys Ala Leu Met Arg Gln Val Val Ala Val Leu Asp Lys Val 
    50                  55                  60                  


Val Gly Lys Arg Arg Arg Leu Ser Gly Met His Pro Glu Ala Tyr Arg 
65                  70                  75                  80  


Asp Arg Val His Leu Ala Glu Ala Leu Trp Val Arg Leu Val Ala Arg 
                85                  90                  95      


Val Lys Glu Ile Gly Thr Pro Pro Asp Pro Ser Glu Leu Leu Asp Leu 
            100                 105                 110         


Arg Arg Met Trp Asn Ala Lys Ala His Pro Tyr Ala Glu Tyr Asp Val 
        115                 120                 125             


Val Pro Arg Ala Pro Leu Asn Asp Gly Asn Gly Gln Lys Ile Leu Glu 
    130                 135                 140                 


Cys Arg Glu Val Asp Asp Pro Lys Ile Glu Arg Ser Asp Phe Glu Gly 
145                 150                 155                 160 


Arg Trp His Gly Arg Phe Trp Gln Ser Glu Pro Gly Pro Val Asp Tyr 
                165                 170                 175     


Asn Ala Ile Ala Asp Arg Ile Phe Ala His Leu Phe Asp Gln Glu Ala 
            180                 185                 190         


Val Ile Gly Gly Gly Pro Arg Arg Glu Gly Asn Val Thr Val Pro Asp 
        195                 200                 205             


Glu Asp Ile Asn Gly Gln Pro Gly Pro Ala Thr Gly Lys Gly Leu Ile 
    210                 215                 220                 


Ile Ala Arg Gly Gln Ser Ile Val Lys Ser Ala Ser Asp Pro Arg Arg 
225                 230                 235                 240 


Ser Ser Lys Lys Val Gln Arg Thr Trp Asp Lys Ala Val Glu Arg Arg 
                245                 250                 255     


Tyr Phe Gly Asp Asp Gly Lys Gly Gly Ser Asp Ile Ala Lys Ala Ile 
            260                 265                 270         


Tyr Glu Glu Leu Gly Asp Pro Ala Thr Leu Ala Asp Pro Ile Tyr Ala 
        275                 280                 285             


Ser Trp Phe Gly Ser Arg Leu Tyr Asp His Phe Gly Ser Phe Lys Asn 
    290                 295                 300                 


Ser Leu Pro Leu Glu Leu Lys Asp Pro Phe Lys Glu Gln Ile Trp Ala 
305                 310                 315                 320 


Leu His Asn Ser Val Arg Gln Phe Tyr Gln Arg Met Ala Lys Ser Asp 
                325                 330                 335     


Arg Phe Arg Leu Ala Leu Gln Asn Ala Arg Ser Glu Val Pro Asp Arg 
            340                 345                 350         


Ser Glu Leu Leu Ala Leu Leu Pro Lys Asp His Asp His Leu Leu Leu 
        355                 360                 365             


Val Leu Gly Gly Lys Lys Lys Asn Ala Glu Met Ser Glu Leu Ile Arg 
    370                 375                 380                 


Leu Gly Lys Leu Phe Val His Ala Ser Asp Val Leu His Asp Phe Asp 
385                 390                 395                 400 


Ala Asn Asp Ala Ala Ala Leu Asp Ala Phe Lys Arg Arg Met Ser Phe 
                405                 410                 415     


Leu Ala Thr Ser Ile Gly Gln Ser Glu Ile Lys Gln Thr Glu Thr Phe 
            420                 425                 430         


Ala Arg Thr Trp Arg Gly Ala Val Gly Leu Thr Leu Arg Thr Val Lys 
        435                 440                 445             


Gly Leu Ala Asp Pro Arg Gly Ile Ile Gly Thr Pro Asp Asn Arg Asp 
    450                 455                 460                 


Leu Gly Thr Ala Gly Pro Met Lys Asp Ala Phe Asn Lys Phe Asp Gln 
465                 470                 475                 480 


Pro His Phe Gln Gln His Met Thr Ile Ile Phe Gly Asn Lys Glu Leu 
                485                 490                 495     


Gln Ala Glu Gly Asn Pro Thr Arg Ser Ser Val Phe Thr Ala Asn Gly 
            500                 505                 510         


Asp Lys Asp His Gln Ala Glu Leu Leu Trp Gly Phe Leu Cys Val Val 
        515                 520                 525             


Arg Ser Val Arg Asn Arg Thr Asn His Tyr Asn Val Arg Arg Ala Leu 
    530                 535                 540                 


Leu Arg Leu Leu Asp Glu Gly Ile Val Ser Pro Met Pro Ser Asp Pro 
545                 550                 555                 560 


Lys Lys Glu Arg Val Glu Asn Arg Asn Leu Cys Thr Val Ser Pro Thr 
                565                 570                 575     


Ala Leu Glu Ala Phe Arg Arg Leu Leu Asn Phe Asp Leu Ala Ile Gln 
            580                 585                 590         


Lys Glu Ala Val Arg Thr Ala Leu Glu Gln Ala Lys Ala Ser Glu Phe 
        595                 600                 605             


Val Glu Glu Gly Lys Leu Arg Gly Leu Val Ser Glu Leu Ala Gly Thr 
    610                 615                 620                 


Glu Asp Met Pro Ala Leu His Ile Pro Arg Phe Ser Ala Val Met Asp 
625                 630                 635                 640 


Lys Val Arg Arg Leu Ala Asp Asn Arg Asp Val Gly Leu Asp Pro Ile 
                645                 650                 655     


Leu Ser Thr Leu Gln Arg Ser Leu Pro Pro Thr Asp Lys Gln Ala Glu 
            660                 665                 670         


Ser Asp Ala Ala Arg Cys Arg Tyr Arg Leu Leu Leu Glu Leu Tyr Lys 
        675                 680                 685             


Ser Gly Phe Arg Ser Trp Phe Ser Gly Ile Gln Ser Asn Glu Glu Asn 
    690                 695                 700                 


Asn Arg Glu Ile Cys His Trp Ala Val Lys Gln Val Gly Arg Ala Lys 
705                 710                 715                 720 


Asp Ala Arg Lys Ser Glu Tyr Asp Lys Lys Thr Lys Arg His Tyr Arg 
                725                 730                 735     


Ser Pro Asn Ser Leu Ile Asp Asp Leu Gly Leu Asp Lys Phe Asp Asp 
            740                 745                 750         


Leu Thr Asp Leu Leu Glu Ala Leu Ala Ser Gln Ser Thr Arg Glu His 
        755                 760                 765             


Asp Gln Asn Leu Lys Tyr Val Pro Asp Ala Arg Val Gln Ser Gln Met 
    770                 775                 780                 


Ser Asn Arg Ile Glu Glu Phe Arg Gln Glu Leu Phe Ala His Ile Phe 
785                 790                 795                 800 


Thr Lys Tyr Leu Asp Thr His Asp Phe Gly Trp Ile Gly Ala Ile Glu 
                805                 810                 815     


Val Arg Arg Glu Ala Cys Asp Leu Ala Asp Val Val Ser Ala Phe Glu 
            820                 825                 830         


Val Arg Asp Gln Lys Phe Asp Ala Asp Trp His Ser Gln Phe Tyr Ala 
        835                 840                 845             


Trp Leu Tyr Met Val Pro Pro Ile Glu Ala Ser Arg Leu Arg His Gln 
    850                 855                 860                 


Met Arg Lys Ser Ala Val Met Asp Asp Lys Trp Ser Thr Thr Leu Glu 
865                 870                 875                 880 


Leu Thr Ser Gly Asp Arg Lys Thr Arg Asp Asp His Ala Gln Asp Val 
                885                 890                 895     


Leu Ala Asp Met Asp Arg Leu Phe Ser Leu Tyr Thr Lys Val Gln Ala 
            900                 905                 910         


Ala Gly Phe Asn Gly Gln Glu His Glu Ser Ala Leu Gly Ser Lys Ser 
        915                 920                 925             


Leu Phe Tyr Glu Asp Gly Asn Gln Phe Asp Glu Val Tyr Ser Pro Asp 
    930                 935                 940                 


Thr Glu Thr His Asn Lys Thr Phe Pro Gly Thr Arg Arg Gly Leu Arg 
945                 950                 955                 960 


Gln Leu Val Arg Tyr Ala His Leu Pro Ala Leu Glu Gly Val Phe Lys 
                965                 970                 975     


Lys His Arg Ile Thr Lys Ala Glu Val Glu Thr Phe Val Ala Leu Tyr 
            980                 985                 990         


Asp Glu Asn Arg Arg Asp Pro Gly  Ser Val Ala His Met  Leu Arg Arg 
        995                 1000                 1005             


Glu Lys  Leu Arg Thr Glu Ile  Leu Arg Ser Ile His  Asp Gly Pro 
    1010                 1015                 1020             


Lys Pro  Lys Asp Lys Asp Phe  Trp Pro Lys Leu Glu  Ala Lys Cys 
    1025                 1030                 1035             


Leu Glu  Tyr Arg Thr Val Ala  Thr Glu Thr Ala Ile  Tyr Asn Phe 
    1040                 1045                 1050             


Gln Ala  Asn Ala Ala Arg Leu  Asn Asp His Ala Arg  Leu His Gln 
    1055                 1060                 1065             


Ile Val  Met Arg Val Val Ala  Arg Leu Thr Asp Tyr  Ala Leu Ile 
    1070                 1075                 1080             


Trp Glu  Arg Asp Arg Leu Phe  Ala Phe Val Gly Met  Leu Tyr Arg 
    1085                 1090                 1095             


Gln Thr  Gly Gly Thr Gly Ile  Asn Pro Ala Met Arg  His Ala Glu 
    1100                 1105                 1110             


Lys Thr  Asn Ala Pro Pro Arg  Ile Gly Ile Leu Val  Ser Asp Ser 
    1115                 1120                 1125             


Ala Leu  Ala Lys Lys Leu Asn  Ser Asn Ser Ala Glu  Val Phe Ile 
    1130                 1135                 1140             


Pro Tyr  Leu Asp Thr Glu Thr  Gly Phe Asp Ala Pro  Arg Phe Asp 
    1145                 1150                 1155             


Asp Leu  Cys Thr Leu Leu Ser  His Glu His Ala Lys  Glu Phe Arg 
    1160                 1165                 1170             


Phe His  Phe Leu Glu Val Gly  Glu Glu Asn Ser Lys  Asp Glu Ala 
    1175                 1180                 1185             


Arg Arg  Leu Asn Glu Glu Thr  Met Gly His Arg Lys  Arg Pro Ala 
    1190                 1195                 1200             


Phe Lys  Arg Gly Thr Arg Arg  Gln Gly Ile Arg Asn  Asp Leu Ala 
    1205                 1210                 1215             


His His  Asn Val Leu Asp Leu  Ala Gly Gly Ala Gly  Pro Asn Leu 
    1220                 1225                 1230             


Thr Tyr  Val Val Asn Ala Val  Arg Ser Leu Leu Ser  Tyr Asp Arg 
    1235                 1240                 1245             


Lys Leu  Lys Asn Ala Val Pro  Lys Ser Ile Lys Arg  Ile Leu Gly 
    1250                 1255                 1260             


Glu Glu  Gly Leu Ile Ile Glu  Trp Gln Met Asn Tyr  Asp Arg Leu 
    1265                 1270                 1275             


Lys Lys  Pro Thr Val Tyr Pro  Asn Val Glu Thr His  Leu Thr Met 
    1280                 1285                 1290             


Val Pro  Pro Arg His Met Thr  Ala Pro Val Ser Phe  Thr Leu Pro 
    1295                 1300                 1305             


Arg Ala  Ser Val Arg Leu Ala  Ser Met Val Lys Ala  Val Phe Asp 
    1310                 1315                 1320             


Phe Gly  Ser Ser Gly Tyr Gly  Glu Glu Arg Met Ile  Gly Gly Arg 
    1325                 1330                 1335             


Thr Ala  Lys Gln Ala Val Tyr  Pro Asp Asp Phe Thr  Arg Arg Phe 
    1340                 1345                 1350             


Pro Gln  Thr Pro Met Gly Leu  Lys Gln Ala Thr Arg  Leu Val Phe 
    1355                 1360                 1365             


Ala Ser  Glu Asn Ser 
    1370             


<210>  481
<211>  1429
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  481

Met Gly Asn Leu Phe Gly Tyr Lys Lys Trp Tyr Lys Val Asp Lys Ile 
1               5                   10                  15      


Ile Glu Gly Lys Glu Gly Glu Val Thr Lys Ile Lys Lys Glu Val Arg 
            20                  25                  30          


Ile Lys Arg Lys Tyr Leu Asp Asn Glu Ser Lys Tyr Val Leu Asn Ile 
        35                  40                  45              


Asn Lys Gln Glu Glu Glu Asp Lys Ser Lys Ile Thr Asn Glu Asp Phe 
    50                  55                  60                  


Ile Asn Gln Phe Ile Lys Tyr Lys Thr Lys Asn Asp Ile Phe Lys Lys 
65                  70                  75                  80  


Phe Thr Glu Lys Phe His Met Gly Asn Ile Leu Phe Lys Leu Lys Gly 
                85                  90                  95      


Lys Ser Gln Lys Gly Lys Ile Ile Asn Asp Lys Asp Phe Leu Glu Thr 
            100                 105                 110         


Glu Glu Ile Val Leu Asp Lys Glu Val Tyr Gly Gln Ser Glu Lys Leu 
        115                 120                 125             


Arg Asn Glu Lys Gly Ile Thr Lys Gln Gly Ile Ile Lys Glu Ile Ile 
    130                 135                 140                 


Asp Lys Gly Ile Asn Lys Ser Asn Gly Ser Ile Ser Ile Lys Thr Lys 
145                 150                 155                 160 


Phe Gly Lys Lys Ile Lys Ile Asn Phe Thr Asp Glu Ser Lys Lys Asn 
                165                 170                 175     


Lys Asn Glu Tyr Gln Ile Thr Leu Lys Val Ile Pro Lys Asn Glu Leu 
            180                 185                 190         


Lys Ile Lys Arg Glu Ile Tyr Asn Ile Phe Lys Asp Ile Asn Thr Asn 
        195                 200                 205             


Leu Tyr Leu Thr Phe Glu Glu Ile Phe Asn Gln Glu Lys Asn Arg Glu 
    210                 215                 220                 


Ile Phe Lys Asn Arg Asn Tyr Ser Asp Phe Leu Lys Glu Lys Leu Leu 
225                 230                 235                 240 


Lys Glu Lys Lys Ile Lys Asn Leu Leu Glu Tyr Phe Asn Thr Ile Arg 
                245                 250                 255     


Glu Thr Ile Lys Asp Asn Ser Asp Asn Thr Ser Ser Phe Val Lys Phe 
            260                 265                 270         


His Leu Asn Val Gly Gly Asp Lys Lys Lys Ser Glu Asn Lys Lys Ile 
        275                 280                 285             


Phe Val Glu Lys Ile Leu Asn Ile Asn Val Asp Leu Thr Ile Glu Asp 
    290                 295                 300                 


Ile Val Asp Phe Ile Val Lys Glu Leu Lys Phe Tyr Gly Ile Ile Lys 
305                 310                 315                 320 


Arg Ile Glu Lys Leu Gln Lys Glu Gly Asn Arg Thr Lys Thr Glu Ile 
                325                 330                 335     


Lys Asn Thr Tyr Ile Lys Ser Tyr Val Leu Leu Asp Arg His Glu Lys 
            340                 345                 350         


Phe Lys Lys Tyr Asn Arg Asn Lys Lys Asp Glu Ile Val Lys Leu Phe 
        355                 360                 365             


Val Lys Asp Ile His Asn Asn Thr Met Glu Glu Lys Ile Asn Gln Ile 
    370                 375                 380                 


Leu Ser Lys Phe Lys Ile Lys Glu Leu Thr Glu Lys Leu Lys Glu Asn 
385                 390                 395                 400 


Pro Lys Asn Lys Asn Phe Asp Thr Glu Ile Phe Gly Ile Phe Lys Val 
                405                 410                 415     


His Tyr Gln Glu Met Phe Ser Ser Glu Lys Phe Glu Glu Lys Ser Asp 
            420                 425                 430         


Glu Glu Lys Glu Leu Tyr Lys Ile Ile Tyr Arg Tyr Leu Lys Gly Arg 
        435                 440                 445             


Ile Glu Lys Ile Leu Ile Asn Glu Glu Lys Val Arg Leu Lys Lys Met 
    450                 455                 460                 


Glu Lys Ile Leu Ile Asn Gly Glu Lys Ile Arg Leu Asn Lys Ile Glu 
465                 470                 475                 480 


Lys Ile Glu Ile Glu Lys Ile Leu Asn Glu Ser Ile Leu Ser Glu Lys 
                485                 490                 495     


Ile Leu Lys Arg Val Lys Gln Tyr Thr Leu Glu Tyr Ile Met Tyr Leu 
            500                 505                 510         


Gly Lys Leu Val His Asn Asn Ile Asp Met Thr Thr Val Asn Thr Asn 
        515                 520                 525             


Asp Phe Ser Lys Leu His Ala Lys Glu Glu Leu Asp Leu Glu Leu Ile 
    530                 535                 540                 


Thr Phe Phe Ala Ser Thr Asn Met Glu Leu Asn Lys Ile Phe Ser Arg 
545                 550                 555                 560 


Glu Asn Ile Asn Asn Asp Glu Asn Ile Asp Phe Phe Gly Gly Asp Arg 
                565                 570                 575     


Glu Lys Asn Tyr Val Leu Asp Lys Lys Asn Leu Asn Ser Lys Ile Lys 
            580                 585                 590         


Ile Ile Arg Asp Leu Asp Phe Ile Asp Asn Lys Asn Asn Ile Thr Asn 
        595                 600                 605             


Asp Phe Ile Asn Lys Phe Thr Lys Ile Gly Thr Asn Glu Arg Asn Arg 
    610                 615                 620                 


Ile Leu His Ala Ser Gly Lys Lys Arg Asp Ser Gln Gly Thr Gln Asp 
625                 630                 635                 640 


Asp Tyr Asn Lys Val Ile Asn Ile Ile Gln Asn Leu Lys Ile Ser Asp 
                645                 650                 655     


Glu Glu Val Ser Lys Val Leu Asn Leu Asp Val Val Phe Lys Asp Lys 
            660                 665                 670         


Lys Asn Ile Ile Thr Glu Ile Asn Asp Ile Lys Ile Ser Glu Lys Asn 
        675                 680                 685             


Ser Asn Asp Ile Lys Tyr Leu Pro Ser Phe Ser Lys Val Leu Pro Glu 
    690                 695                 700                 


Ile Leu Asn Leu Tyr Arg Asn Asn Pro Lys Asn Glu Pro Phe Asp Thr 
705                 710                 715                 720 


Val Glu Thr Glu Lys Ile Val Leu Asn Ala Leu Ile Tyr Val Asn Lys 
                725                 730                 735     


Glu Leu Tyr Lys Lys Leu Ile Leu Glu Asp Asp Leu Gln Glu Asn Arg 
            740                 745                 750         


Ser Lys Asn Ile Phe Leu Gln Glu Leu Lys Lys Thr Leu Gly Asn Ile 
        755                 760                 765             


Asp Glu Thr Asp Glu Asn Ile Ile Glu Asn Tyr Tyr Lys Asn Ala Gln 
    770                 775                 780                 


Ile Ser Ala Ser Lys Gly Asn Asn Lys Ala Ile Lys Lys Tyr Gln Lys 
785                 790                 795                 800 


Lys Val Ile Glu Cys Tyr Ile Gly Tyr Leu Arg Lys Asn Tyr Glu Lys 
                805                 810                 815     


Leu Phe Asp Phe Ser Asp Phe Lys Met Asn Ile Gln Glu Ile Lys Lys 
            820                 825                 830         


Gln Ile Lys Asp Ile Asn Asp Asn Lys Thr Tyr Glu Arg Ile Thr Ile 
        835                 840                 845             


Lys Thr Ser Asp Lys Ser Thr Val Ile Asn Asp Asp Phe Glu Tyr Ile 
    850                 855                 860                 


Ile Ser Ile Phe Ala Leu Leu Asn Ser Asn Ala Val Ile Asn Lys Ile 
865                 870                 875                 880 


Arg Asn Arg Phe Phe Ala Thr Ser Val Trp Leu Asp Thr Ser Glu Tyr 
                885                 890                 895     


Gln Asn Ile Ile Asn Ile Leu Asp Glu Ile Met Gln Leu Asn Thr Leu 
            900                 905                 910         


Arg Asn Glu Cys Ile Thr Glu Asn Trp Asn Leu Asn Leu Glu Glu Phe 
        915                 920                 925             


Ile Gln Lys Met Lys Glu Ile Glu Lys Asp Phe Asp Asp Phe Lys Ile 
    930                 935                 940                 


Gln Thr Lys Lys Asp Ile Phe Asn Gly Asn Tyr Glu Ser Ile Lys Asn 
945                 950                 955                 960 


Asn Val Leu Ser Lys Phe Ile Gly Phe Ser Asp Val Gln Lys Ile Leu 
                965                 970                 975     


Glu Glu Lys Leu Asn Asn Leu Ile Asp Phe Glu Asn Asp Asn Glu Ile 
            980                 985                 990         


Lys Lys Ser Val Asn Leu Asp Ser  Leu Asn Pro Asp Glu  Arg Arg Asn 
        995                 1000                 1005             


Leu Met  Pro Asn Ile Asn Pro  Lys Lys Asp Gly Ile  Asp Leu Ile 
    1010                 1015                 1020             


Lys Glu  Ile Asp Lys Leu Ile  Val Ile Lys Lys Asn  Asn Ile Glu 
    1025                 1030                 1035             


Lys Asn  Ile Leu Leu Lys Ile  Ile Phe Asn Ser Asp  Phe Leu Glu 
    1040                 1045                 1050             


Lys Tyr  Lys Lys Glu Ile Asp  Asn Leu Leu Gly Asp  Thr Glu Thr 
    1055                 1060                 1065             


Glu Asn  Lys Asn Lys Phe Glu  Lys Ile Tyr Tyr Pro  Glu Glu His 
    1070                 1075                 1080             


Lys Asn  Glu Leu Tyr Ile Tyr  Lys Lys Asn Leu Phe  Leu Asn Ile 
    1085                 1090                 1095             


Gly Asn  Pro Asn Phe Asp Lys  Ile Tyr Gly Leu Ile  Ser Asn Asp 
    1100                 1105                 1110             


Ile Lys  Met Ala Asp Ala Lys  Phe Leu Phe Asp Ser  Asp Ser Lys 
    1115                 1120                 1125             


Asp Ile  Arg Asn Asn Glu Ile  Ser Lys Ile Asp Gly  Ile Leu Lys 
    1130                 1135                 1140             


Asn Leu  Asn Asp Lys Leu Asn  Gly Tyr Ser Lys Glu  Tyr Lys Glu 
    1145                 1150                 1155             


Lys Tyr  Val Lys Lys Leu Lys  Glu Ser Asn Asp Phe  Phe Ala Lys 
    1160                 1165                 1170             


Asn Ile  Gln Asn Glu Asn Tyr  Ser Ser Phe Glu Glu  Phe Glu Lys 
    1175                 1180                 1185             


Asn Tyr  Asn Lys Ile Ser Glu  Tyr Lys Lys Ile Arg  Asp Leu Val 
    1190                 1195                 1200             


Glu Phe  Asn Tyr Leu Asn Lys  Ile Glu Ser Tyr Leu  Ile Asp Ile 
    1205                 1210                 1215             


Asn Trp  Lys Leu Ala Ile Gln  Met Ala Arg Phe Glu  Arg Asp Met 
    1220                 1225                 1230             


His Tyr  Ile Val Asn Gly Leu  Lys Lys Leu Asn Phe  Ile Asn Leu 
    1235                 1240                 1245             


Asn Gly  Tyr Asn Thr Gly Ile  Ser Arg Ala Tyr Pro  Lys Tyr Asn 
    1250                 1255                 1260             


Asp Thr  Asp Ser Asn Lys Asn  Cys Lys Lys Phe Tyr  Glu Thr Thr 
    1265                 1270                 1275             


Ala Tyr  Tyr Lys Phe Phe Asp  Asp Lys Ser Tyr Arg  Glu Phe Glu 
    1280                 1285                 1290             


Asp Ile  Cys Tyr Glu Phe Gly  Ile Asp Leu Arg Lys  Asn Ser Asn 
    1295                 1300                 1305             


Ile Gln  Ala Lys Glu Glu Arg  Asn Ile Arg Asn Tyr  Ile Ser His 
    1310                 1315                 1320             


Phe Tyr  Ile Val Arg Asn Pro  Phe Val Asp Tyr Ser  Ile Ala Glu 
    1325                 1330                 1335             


Gln Ile  Asp Arg Val Ser Asn  Leu Leu Ser Tyr Ser  Thr Arg Tyr 
    1340                 1345                 1350             


Asn Asn  Ser Thr Tyr Ala Ser  Val Phe Glu Val Phe  Lys Lys Asp 
    1355                 1360                 1365             


Val Asp  Leu Asp Tyr Asp Glu  Leu Lys Lys Lys Phe  Lys Leu Ile 
    1370                 1375                 1380             


Gly Asp  Asn Asp Ile Leu Glu  Lys Leu Met Lys Ser  Lys Lys Val 
    1385                 1390                 1395             


Ser Val  Leu Glu Leu Glu Ser  Tyr Asn Ser Asp Tyr  Val Lys Asn 
    1400                 1405                 1410             


Leu Ile  Ile Lys Leu Leu Thr  Lys Ile Glu Asn Thr  Asn Asp Thr 
    1415                 1420                 1425             


Leu 
    


<210>  482
<211>  1212
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  482

Met Lys Ile Thr Lys Ile Asp Gly Val Ser His Tyr Lys Lys Gln Asp 
1               5                   10                  15      


Lys Gly Ile Leu Lys Lys Lys Trp Arg Asp Leu Asp Glu Gly Lys Gln 
            20                  25                  30          


Arg Glu Lys Ile Glu Ala Arg Tyr Asn Lys Gln Ile Glu Ser Lys Ile 
        35                  40                  45              


Tyr Lys Glu Phe Phe Arg Leu Lys Ser Gly Lys Asp Ser Glu Arg Ile 
    50                  55                  60                  


Thr Lys Glu Lys Asn Glu Gly Ile Lys Ser Leu Tyr Tyr Leu Ile Lys 
65                  70                  75                  80  


Glu Leu Tyr Glu Gly Lys Glu Asn Asp Leu Trp Glu Leu Lys Asn Ile 
                85                  90                  95      


Asn Leu Glu Ile Leu Gly Asp Lys Glu Arg Ile Ile Lys Gly Tyr Lys 
            100                 105                 110         


Phe Lys Glu Asp Val Tyr Phe Phe Lys Glu Gly Asp Lys Glu Tyr Tyr 
        115                 120                 125             


Leu Arg Thr Leu Phe Asn Asn Leu Ile Glu Lys Val Gln Asn Glu Asn 
    130                 135                 140                 


Arg Glu Lys Val Arg Lys Asn Lys Glu Phe Leu Asp Leu Lys Glu Ile 
145                 150                 155                 160 


Phe Lys Lys Tyr Lys Asp Arg Lys Ile Asp Leu Leu Leu Lys Ser Ile 
                165                 170                 175     


Asn Asn Asn Lys Ile Asn Leu Glu Tyr Lys Lys Glu Asn Val Asn Glu 
            180                 185                 190         


Glu Ile Tyr Gly Ile Asn Pro Thr Asn Asp Arg Glu Met Ile Phe Tyr 
        195                 200                 205             


Glu Leu Leu Lys Glu Ile Ile Glu Lys Lys Asp Glu Gln Lys Ser Ile 
    210                 215                 220                 


Leu Glu Glu Lys Leu Asp Asn Phe Asp Ile Thr Asn Phe Leu Glu Asn 
225                 230                 235                 240 


Ile Glu Lys Ile Phe Asn Glu Glu Thr Glu Ile Asn Ile Ile Lys Gly 
                245                 250                 255     


Lys Val Leu Asn Glu Leu Arg Glu Tyr Ile Lys Glu Lys Glu Glu Asn 
            260                 265                 270         


Asn Ser Asp Asn Lys Leu Lys Gln Ile Tyr Asn Leu Glu Leu Lys Lys 
        275                 280                 285             


Tyr Ile Glu Asn Asn Phe Ser Tyr Lys Lys Gln Lys Ser Lys Ser Lys 
    290                 295                 300                 


Asn Gly Lys Asn Asp Tyr Leu Tyr Leu Asn Phe Leu Lys Lys Ile Met 
305                 310                 315                 320 


Phe Ile Glu Glu Val Asp Glu Lys Lys Glu Ile Asn Lys Glu Lys Phe 
                325                 330                 335     


Lys Asn Lys Ile Asn Ser Asn Phe Lys Asn Leu Phe Val Gln His Ile 
            340                 345                 350         


Leu Asp Tyr Gly Lys Leu Leu Tyr Tyr Lys Glu Asn Asp Glu Tyr Ile 
        355                 360                 365             


Lys Asn Thr Gly Gln Leu Glu Thr Lys Asp Leu Glu Tyr Ile Lys Thr 
    370                 375                 380                 


Lys Glu Thr Leu Ile Arg Lys Met Ala Val Leu Val Ser Phe Ala Ala 
385                 390                 395                 400 


Asn Ser Tyr Tyr Asn Leu Phe Gly Arg Thr Glu Asn Asn Ile Leu Thr 
                405                 410                 415     


Gln Glu Ile Ser Asp Asp Leu Leu Leu Gly Lys Val Glu Asn Glu Arg 
            420                 425                 430         


Tyr Ile Lys Gly Glu Arg Asn Arg Lys Tyr Val Phe Lys Glu Lys Met 
        435                 440                 445             


Leu Asn Tyr Phe Phe Asn Ser Glu Ile Phe Gly Asp Asn Lys Ile Val 
    450                 455                 460                 


Glu Val Leu Asn Ala Ile Ser Ser Ser Ile Tyr Asn Ile Arg Asn Gly 
465                 470                 475                 480 


Val Asn His Phe Asp Lys Met Val Leu Gly Lys Tyr Asn Asn Gly Leu 
                485                 490                 495     


Asp Leu Lys Asp Ser Asp Thr Ile Lys Asp Tyr Phe Asn Phe Lys Lys 
            500                 505                 510         


Lys Glu Ile Gln Gln Asp Leu Lys Asp Arg Phe Ile Ser Asn Asn Leu 
        515                 520                 525             


Gln Tyr Tyr Tyr Thr Glu Asn Glu Ile Lys Lys Tyr Phe Glu Lys Tyr 
    530                 535                 540                 


Lys Phe Glu Ile Leu Lys Thr Lys Ala Ser Phe Ala Pro Asn Phe Lys 
545                 550                 555                 560 


Arg Ile Leu Ile Lys Gly Glu Asn Leu Ser Ile Ser Glu Ser Asn Asn 
                565                 570                 575     


Ser Tyr Glu Phe Phe Lys Ala Tyr Ser Glu Ser Ser Asp Lys Asn Thr 
            580                 585                 590         


Glu Tyr Asn Glu Phe Met Lys Thr Arg Asn Phe Leu Leu Lys Glu Leu 
        595                 600                 605             


Tyr Tyr Asn Asn Phe Tyr Thr Glu Phe Leu Asn Asp Lys Ala Lys Phe 
    610                 615                 620                 


Arg Glu Ala Val Glu Lys Val Lys Lys Asn Lys Lys Arg Arg Gly Gly 
625                 630                 635                 640 


Lys Ser Tyr Asp Val Ile Gly Asn Tyr Asn Phe Ser Asp Ser Ile Ser 
                645                 650                 655     


Glu Tyr Ile Ser Tyr Ile His Lys Ser Glu Met Glu Arg Ile Glu Ile 
            660                 665                 670         


Asn Thr Glu Lys Asn Arg Lys Asp Thr Ser Lys His Ile Arg Asp Phe 
        675                 680                 685             


Ile Glu Glu Ile Phe Leu Glu Gly Phe Ile Glu Tyr Leu Asp Asn Asn 
    690                 695                 700                 


Asn Phe Lys Phe Leu Lys Asn Arg Asn Glu Val Asp Lys Glu Arg Glu 
705                 710                 715                 720 


Glu Ile Val Arg Asn Leu Asn Ile Gln Ile Glu Gly Leu Asp Ile Leu 
                725                 730                 735     


Asn Glu Asp Asp Ser Glu Thr Leu Asn Leu Tyr Leu Phe Phe Asn Met 
            740                 745                 750         


Ile Asp Asn Lys Arg Ile Ser Glu Phe Arg Asn Asp Met Ile Lys Tyr 
        755                 760                 765             


Lys Gln Phe Leu Ala Lys Arg Gln Asn Ile Asp Arg Lys Phe Leu Lys 
    770                 775                 780                 


Ile Asp Ile Glu Lys Ile Glu Ala Ile Ile Glu Phe Val Ile Ile Thr 
785                 790                 795                 800 


Lys Glu Lys Leu Glu Ile Leu Glu Gly Glu Thr Lys Glu Gln Lys Lys 
                805                 810                 815     


Asp Asn Met Asn Ala Leu Phe Asn Lys Phe Tyr Ser Ser Glu Ser Glu 
            820                 825                 830         


Tyr Asp Glu Ser Leu Lys Lys Phe Ile Glu Glu Ile Val Leu Asn Asp 
        835                 840                 845             


Lys Lys Asn Thr Pro Phe Tyr Ser Thr Asp Gly Lys Thr Pro Ile Val 
    850                 855                 860                 


His Ser Asn Leu Glu Lys Met Arg Lys Tyr Gly Thr Glu Asn Phe Leu 
865                 870                 875                 880 


Ser Lys Val Leu Lys Asp Ser Lys Tyr Thr Leu Asn Asn Met Thr Thr 
                885                 890                 895     


Lys Glu Lys Phe Glu Ala Glu Val Ser Asp Glu Leu Lys Glu Tyr Lys 
            900                 905                 910         


Ile Leu Glu Lys Val Ser Arg Phe Lys Glu Asn Glu Lys Pro Lys Lys 
        915                 920                 925             


Val Ile Glu Tyr Tyr Asn Asp Cys Arg Cys Tyr Leu His Lys Glu Trp 
    930                 935                 940                 


Ile Glu Lys Lys Lys Ser Lys Glu Lys Phe Glu His Lys Glu Trp Ile 
945                 950                 955                 960 


Glu Asn Lys Lys Asn Lys Glu Glu Phe Glu His Lys Glu Ile Tyr Lys 
                965                 970                 975     


Lys Ile Ile Glu Glu Ile Arg Lys Tyr Asn Tyr Leu Glu Asn Lys Glu 
            980                 985                 990         


Lys Leu Gln Asn Val Tyr Leu Leu  His Glu Met Leu Ser  Asp Leu Leu 
        995                 1000                 1005             


Ala Arg  Asn Val Ala Phe Leu  Asn Lys Trp Glu Arg  Asp Phe Lys 
    1010                 1015                 1020             


Phe Ile  Val Ile Ala Ile Lys  Gln Phe Leu Arg Glu  Asn Asp Lys 
    1025                 1030                 1035             


Glu Lys  Val Asp Glu Phe Leu  Asn Pro Tyr Lys Ser  Asp Gly Ser 
    1040                 1045                 1050             


Arg Asp  Asn Phe Ser Val Thr  Asn Tyr Arg Ser Lys  Met Arg Leu 
    1055                 1060                 1065             


Val Ile  Asn Asn Ile His Glu  Asn Phe Met Ser Leu  Leu Phe Leu 
    1070                 1075                 1080             


Asn Asp  Asn Leu Ala Ile Arg  Glu Ile Thr Ala Asn  Asn Phe Thr 
    1085                 1090                 1095             


Trp Val  Asn Leu Arg Asn Tyr  Ile Ala His Phe Glu  Tyr Leu His 
    1100                 1105                 1110             


Glu Glu  Lys Asp Thr Ile Ser  Phe Ile Val Gln Ala  Asn Leu Leu 
    1115                 1120                 1125             


Ile Lys  Leu Phe Ser Tyr Asp  Lys Lys Val Gln Asn  His Ile Leu 
    1130                 1135                 1140             


Lys Ser  Ile Lys Thr Leu Leu  Glu Lys Tyr Asn Ile  Gln Ile Ser 
    1145                 1150                 1155             


Phe Lys  Ile Pro Lys Asp Glu  Asp Lys Asn Glu Thr  Phe Arg Tyr 
    1160                 1165                 1170             


Glu Ile  Lys Asn Gln Leu Tyr  Ser Lys Lys Gly Lys  Met Leu Gly 
    1175                 1180                 1185             


Lys Asn  Asn Lys Phe Glu Ile  Leu Glu Asn Glu Phe  Leu Glu Asn 
    1190                 1195                 1200             


Val Lys  Ala Met Leu Glu Tyr  Ser Lys 
    1205                 1210         


<210>  483
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  483

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Gly Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Trp Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Asn Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Phe Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Ile His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Ile  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Arg Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  484
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  484

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Leu Tyr Gln Ile Val  Ser Ala Phe Asn Phe  Gly Ser Lys 
    1205                 1210                 1215             


Leu Leu  Tyr Ile Ser Glu Asp  Gly Arg Trp Lys Met  Ala Gly Gly 
    1220                 1225                 1230             


Ala Phe  Pro Gly Lys Tyr Gly  Arg Phe Glu Asn Asp  Tyr Asn His 
    1235                 1240                 1245             


Arg Thr  Ser Leu Ser Lys Val  Ile Arg Leu Phe Glu  Asn Glu Ser 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ile Ile Tyr  Trp Arg Asp Tyr Val  Asp His Met 
    1265                 1270                 1275             


Lys Tyr  Tyr Val Asn Gln Asn  Gln Ser Ile Met Glu  Ile Tyr Ser 
    1280                 1285                 1290             


Ala Phe  Tyr Ser Lys Val Leu  Gly Tyr Ser Ala Lys  Leu Arg Lys 
    1295                 1300                 1305             


Ser Val  Val Phe Asn Leu Gln  Ala Ala Leu Glu Lys  His His Ile 
    1310                 1315                 1320             


Asn Pro  Glu Cys Ile Trp Met  Thr Ser Asp Gly Lys  Cys Ala Asp 
    1325                 1330                 1335             


Ile Lys  Leu Met Lys Asn Leu  Glu Ser Gln Lys Phe  Thr Tyr Lys 
    1340                 1345                 1350             


Leu Ala  Lys Arg Glu Gly Glu  Lys Thr Glu Arg Lys  Ile Cys Met 
    1355                 1360                 1365             


Asn Ala  Leu Asn Glu Asn Phe  Leu Lys Thr Ile Arg  Thr Ser Leu 
    1370                 1375                 1380             


Glu Tyr  Lys Lys 
    1385         


<210>  485
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  485

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Thr Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Lys Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Glu 
        755                 760                 765             


Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Lys Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Ile  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1400                 1405                 1410         


<210>  486
<211>  1186
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  486

Met Lys Val Thr Lys Ile Asp Gly Leu Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ile Glu Asp Ala Ser Gln Lys Asn Glu Thr 
            20                  25                  30          


Leu Glu Arg Leu Glu Lys Leu Lys Glu Ile Lys Leu Gly Asn Tyr Ile 
        35                  40                  45              


Lys Asn Pro Asp Lys Thr Lys Asp Lys Asp Asn Lys Lys Arg Arg Lys 
    50                  55                  60                  


Gly Leu Lys Glu Tyr Phe Ser Glu Ile Thr Leu Arg Lys Glu Asn Glu 
65                  70                  75                  80  


Lys Tyr Val Leu Leu Lys Gly Lys Lys Leu Lys Lys Ile Asn Asn Asp 
                85                  90                  95      


Ile Lys Asp Thr Asp Ile Lys Val Lys Tyr Lys Lys Glu Glu Val Phe 
            100                 105                 110         


Asp Val Leu Lys Lys Ile Leu Lys Leu Asn Leu Leu Ala Asn Asp Val 
        115                 120                 125             


Glu Glu Lys Ile Gln Phe Asp Ser Ile Lys Leu Lys Asn Val Phe Gly 
    130                 135                 140                 


Lys Asp Phe Val Lys Lys Glu Leu Gln Ile Lys Ser Ile Glu Glu Ser 
145                 150                 155                 160 


Leu Glu Lys Asn Lys Ala Asp Tyr Arg Lys Glu Phe Ile Glu Ile Glu 
                165                 170                 175     


Asn Asp Lys Tyr Gly Asn Val Lys Gly Glu Asn Lys Lys Asn Arg Ile 
            180                 185                 190         


Tyr Glu Tyr Tyr Lys Lys Ser Glu Thr His Glu Lys Phe Arg Lys Asn 
        195                 200                 205             


Ile Ile Glu Ala Phe Glu Lys Leu Tyr Lys Lys Asp Asp Ile Glu Lys 
    210                 215                 220                 


Leu Tyr Thr Gln Ile Ile Glu Ile Ser Lys Lys Met His Leu Lys Ser 
225                 230                 235                 240 


Lys Val Arg Glu Leu Tyr Lys Asn Val Ile Ile Lys Arg Ser Cys Asp 
                245                 250                 255     


Asp Phe Ser Lys Lys Asn Lys Glu Gly Ile Ser Val Leu Tyr Ser Gln 
            260                 265                 270         


Ile Met Asn Ser Val Lys Lys Asn Glu Lys Phe Val Lys Phe Val Lys 
        275                 280                 285             


Asn Ile Glu Leu Lys Asp Leu Thr Lys Ser Gln Ile Phe Tyr Lys Tyr 
    290                 295                 300                 


Phe Leu Glu Asn Glu Glu Leu Asn Asp Glu Asn Ile Lys Asn Ile Phe 
305                 310                 315                 320 


Cys Tyr Phe Val Glu Ile Glu Val Ser Asp Leu Leu Lys Gly Asn Val 
                325                 330                 335     


Tyr Lys Val Ser Lys Ile Tyr Glu Asn Lys Ile Lys Asn Ile Phe Glu 
            340                 345                 350         


Tyr Asn Lys Leu Lys Lys Leu Val Ile Asn Lys Leu Glu Asn Lys Leu 
        355                 360                 365             


Asn Asn Tyr Val Arg Asn Cys Gly Lys Tyr Asn Tyr His Met Glu Asn 
    370                 375                 380                 


Gly Asp Ile Ala Thr Ser Asp Ile Asn Met Arg Asn Arg Gln Thr Glu 
385                 390                 395                 400 


Ala Phe Leu Arg Ser Met Ile Gly Val Ser Ser Phe Gly Tyr Phe Ser 
                405                 410                 415     


Leu Arg Asn Ile Leu Gly Val Asn Asp Asp Asp Phe Tyr Glu Ile Glu 
            420                 425                 430         


Glu Asp Leu Thr Glu Glu Glu Arg Lys Asn Glu Ser Asn Val Leu Lys 
        435                 440                 445             


Lys Ala Lys Glu Asp Ile Thr Ser Lys Ser Ile Phe Glu Lys Val Val 
    450                 455                 460                 


Asp Lys Ser Phe Glu Lys Lys Gly Ile His Ser Ile Arg Glu Asn Val 
465                 470                 475                 480 


Lys Met Phe Tyr Gly Asp Ser Phe Asp Lys Ala Asn Glu Asp Glu Leu 
                485                 490                 495     


Lys Gln Phe Phe Val Asn Met Leu Asn Ala Ile Thr Ser Ile Arg His 
            500                 505                 510         


Arg Val Val His Tyr Asn Met Asn Thr Asn Ser Glu Asn Ile Phe Asn 
        515                 520                 525             


Phe Ser Asp Ile Glu Val Ser Arg Leu Leu Lys Ser Ile Phe Glu Lys 
    530                 535                 540                 


Glu Thr Asp Lys Arg Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn 
545                 550                 555                 560 


Ser Ala Gly Val Phe Asp Tyr Trp Glu Asn Trp Lys Ile Lys Lys Tyr 
                565                 570                 575     


Leu Glu Asn Met Lys Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val 
            580                 585                 590         


Pro Ser Phe Thr Lys Leu Tyr Asn Arg Ile Asp Asn Leu Lys Gly Ser 
        595                 600                 605             


Asn Ala Leu Asn Leu Gly Tyr Ile Asn Ile Pro Lys Arg Lys Glu Ala 
    610                 615                 620                 


Arg Asp Ser Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Lys Phe 
625                 630                 635                 640 


Val Glu Glu Phe Ile Lys Asn Asn Asp Asn Phe Glu Lys Ile Phe Arg 
                645                 650                 655     


Glu Ile Ile Glu Ile Asn Lys Asn Ala Gly Thr Asn Lys Gln Thr Asn 
            660                 665                 670         


Phe Tyr Lys Leu Glu Lys Phe Glu Lys Leu Lys Ala Asn Thr Pro Thr 
        675                 680                 685             


Glu Tyr Leu Glu Lys Leu Gln Ser Leu His Lys Ile Asn Tyr Asn Arg 
    690                 695                 700                 


Glu Lys Ile Glu Glu Asp Lys Asp Ile Tyr Val Asp Phe Val Gln Lys 
705                 710                 715                 720 


Ile Phe Leu Lys Gly Phe Ile Ser Tyr Leu Gln Lys Ser Asn Ser Leu 
                725                 730                 735     


Lys Pro Leu Asn Leu Leu Asn Leu Lys Lys Asp Glu Val Ile Asn Ser 
            740                 745                 750         


Glu Lys Ser Phe Tyr Asp Glu Lys Leu Lys Gln Trp Glu Asn Asn Gly 
        755                 760                 765             


Ser Asn Leu Ser Glu Met Pro Lys Glu Ile Tyr Lys Tyr Ile Lys Glu 
    770                 775                 780                 


Ile Lys Ile Asn Lys Thr Asn Tyr Ser Asp Arg Met Ser Ile Phe Tyr 
785                 790                 795                 800 


Leu Leu Leu Lys Leu Ile Asp His Lys Glu Leu Thr Asn Leu Arg Gly 
                805                 810                 815     


Asn Leu Glu Lys Tyr Glu Ser Met Asn Lys Asn Lys Ile Tyr Ser Glu 
            820                 825                 830         


Glu Leu Asn Ile Val Asn Leu Val Ser Leu Asp Asn Asn Lys Val Arg 
        835                 840                 845             


Thr Asn Phe Ser Val Glu Ala Glu Asp Ile Gly Lys Phe Leu Lys Thr 
    850                 855                 860                 


Glu Thr Ser Ile Lys Asn Ile Asn Gln Leu Asn Asn Phe Ser Gly Ile 
865                 870                 875                 880 


Phe Ala Asp Gly Glu Asn Val Ile Lys His Arg Ser Phe Tyr Asn Ile 
                885                 890                 895     


Lys Lys Tyr Gly Ile Leu Asp Leu Leu Glu Lys Ile Val Ala Lys Ala 
            900                 905                 910         


Asp Leu Lys Ile Ala Lys Glu Glu Ile Lys Lys Tyr Glu Asn Leu Gln 
        915                 920                 925             


Lys Glu Leu Glu Lys Asn Asp Phe Tyr Lys Ile Gln Glu Lys Ile His 
    930                 935                 940                 


Arg Lys Tyr Asn Gln Lys Pro Asn Leu Ile Ser Arg Thr Glu Asn Lys 
945                 950                 955                 960 


Lys Asp Phe Asn Asp Tyr Lys Lys Ala Ile Glu Asn Ile Gln Asn Tyr 
                965                 970                 975     


Thr Gln Leu Lys Asn Lys Ile Glu Phe Asn Asp Leu Asn Leu Leu Gln 
            980                 985                 990         


Gly Leu Leu Phe Arg Ile Leu His  Arg Leu Thr Gly Tyr  Thr Ser Leu 
        995                 1000                 1005             


Trp Glu  Arg Asp Leu Gln Phe  Lys Leu Lys Gly Glu  Phe Pro Glu 
    1010                 1015                 1020             


Asp Lys  Tyr Ile Asp Glu Ile  Phe Asn Ser Asp Arg  Asn Asn Asn 
    1025                 1030                 1035             


Gln Lys  Tyr Lys Ser Gly Gly  Ile Ala Tyr Lys Tyr  Val Asp Phe 
    1040                 1045                 1050             


Leu Ile  Glu Lys Glu Glu Gly  Lys Arg Ala Gly Lys  Asn Lys Val 
    1055                 1060                 1065             


Lys Lys  Arg Ser Glu Arg Glu  Arg Ser Phe Ile Ile  Arg Asn Tyr 
    1070                 1075                 1080             


Ile Ala  His Phe Asn Tyr Ile  Pro Asp Ala Glu Lys  Ser Ile Leu 
    1085                 1090                 1095             


Glu Ile  Leu Glu Glu Leu Arg  Glu Leu Leu Lys Tyr  Asp Arg Lys 
    1100                 1105                 1110             


Leu Lys  Asn Ala Val Met Lys  Ser Ile Lys Asp Ile  Phe Lys Glu 
    1115                 1120                 1125             


Tyr Gly  Phe Ile Ile Glu Phe  Gly Ile Ser His Glu  Ser Asn Ser 
    1130                 1135                 1140             


Lys Lys  Ile Lys Val Leu Asn  Val Glu Ser Gly Lys  Ile Lys His 
    1145                 1150                 1155             


Leu Lys  Asn Asn Gly Leu Val  Thr Thr Arg Asn Ser  Lys Asp Leu 
    1160                 1165                 1170             


Cys Lys  Leu Val Lys Val Met  Leu Glu Tyr Lys Lys  Ser 
    1175                 1180                 1185     


<210>  487
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  487

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Asn Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Ser Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Asn Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Glu 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Val Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Thr Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Lys Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Glu  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  488
<211>  1366
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  488

Met Lys Leu Ser Lys Glu Asn His Ile Lys Ser Ala Val Ala Ile Ser 
1               5                   10                  15      


Gly Lys Glu Gly Asn Ile Ala Gly Thr Leu Tyr Lys Ile Pro Gly Glu 
            20                  25                  30          


Gly Thr Val Asp Leu Lys Lys Gln Met Leu Glu Arg Asp Lys Ala Val 
        35                  40                  45              


Lys Arg Leu Tyr Asn Ile Phe Asn Gln Ile Gln Leu Gly Thr Gln Pro 
    50                  55                  60                  


Lys Glu Trp Lys Glu Asn Arg Asn Leu Ser Ala Glu Glu Asn Thr Arg 
65                  70                  75                  80  


Arg Met His Gln Gln Ala Val Lys Ile Gln Asn Tyr Lys Met Lys Lys 
                85                  90                  95      


Ala Cys Ser Lys Tyr Val Asn Ser Ile Arg Lys Thr Ile Asn Gly Leu 
            100                 105                 110         


Leu Phe Tyr Asp Arg Ile Ile Lys Thr Thr Gln Gln Asn Lys Val Lys 
        115                 120                 125             


Ser Asp Arg Leu Lys Met Met Arg Lys Asn Glu Asp Ile Ile Ser Lys 
    130                 135                 140                 


Met Lys Asn Glu Asn Ile Leu Gln Gln Phe Lys Val Glu Gly Glu Asn 
145                 150                 155                 160 


Gly Lys Phe Glu Lys Gly Lys Leu Glu Asp Phe Val Thr Leu Ala Leu 
                165                 170                 175     


Arg Ser Ser Leu Ile Val Ser Arg Tyr Lys Gly Lys Asp Phe Asn Ser 
            180                 185                 190         


Val Ala Ala Val Val Val Phe Leu Asp Asn Ile Gly Asn Asn Asn Ile 
        195                 200                 205             


Ser His Glu Asp Glu Arg Thr Ile Asn Ile Leu Leu Asn Leu Ile Arg 
    210                 215                 220                 


Glu Asp Phe Thr Lys Leu Asn Pro Asn Lys Asp Asn Thr Gln Gly Ala 
225                 230                 235                 240 


Arg Leu Ile Arg Ser Val Thr Asn Gln Asn Met Leu Val Gln Pro Gln 
                245                 250                 255     


Asn Asp Arg Phe Ser Phe Pro Ser Val Ser Asp Ser Gly Lys Ser Lys 
            260                 265                 270         


Val Ser Asn Lys Asn Val Glu Lys Ser Gly Leu Asp Asn Phe Leu Leu 
        275                 280                 285             


Asp Tyr Ala Asn Leu Asn Lys Glu Glu Arg Glu Glu Lys Leu Arg Lys 
    290                 295                 300                 


Leu Arg Arg Ile Ile Asp Val Tyr Phe Ser Ala Pro Ile Thr Tyr Gln 
305                 310                 315                 320 


Lys Asp Met Asp Val Thr Leu Ser Glu Glu Val Val Lys Tyr Lys Phe 
                325                 330                 335     


Asp Val Trp Ile Lys His Asn Gln Gly Lys Lys Asp Asn Asn Met Phe 
            340                 345                 350         


Val Asp Val Pro Asp Val Leu Val Lys Ala Glu Thr Asp Gly Glu Lys 
        355                 360                 365             


Ile Asp Ala Val Ile Glu Lys Gln Ala Arg Lys Glu Leu Thr Asp Arg 
    370                 375                 380                 


Val Arg Glu Gln Asn Met Ile Cys Tyr Arg Tyr Thr Gln Ala Ile Val 
385                 390                 395                 400 


Lys Lys Tyr Asn Ala Asn Glu Ala Leu Phe Phe Glu Asn Asp Asp Ile 
                405                 410                 415     


Asn Gln Tyr Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu 
            420                 425                 430         


Lys Ser Cys Lys Ile Gly Thr Leu Phe Lys Leu Arg Lys Gly Tyr Leu 
        435                 440                 445             


Thr Glu Lys Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr 
    450                 455                 460                 


Ile Ala Ile Gly Lys Val Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp 
465                 470                 475                 480 


Asn Asp Asn Lys Val Lys Lys Leu Gly Asp Ile Ser Glu Lys Ile Arg 
                485                 490                 495     


Ser Gly Ile Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Thr 
            500                 505                 510         


Leu Gln Arg Glu Leu Ala Val Asn Val Ala Phe Ser Ala Asn Asn Leu 
        515                 520                 525             


Ala Arg Ala Val Cys Asp Met Ser Asn Leu Ser Asp Lys Thr Ser Asp 
    530                 535                 540                 


Phe Leu Leu Trp Lys Pro Asp Asp Ile Asn Asp Lys Met Lys Lys Ser 
545                 550                 555                 560 


Thr Gly Asn Asp Asp Asp Asn Glu Lys Asn Lys Lys Ala Val Cys Ala 
                565                 570                 575     


Val Leu Gln Phe Phe Gly Gly Lys Ser Leu Trp Lys Asp Val Asp Phe 
            580                 585                 590         


Glu Lys Ala Tyr Lys Asn Ala Gly Lys His Gly Tyr Gly Val Tyr Tyr 
        595                 600                 605             


Ile Asn Asp Leu Arg Lys Ala Ile Phe Ala Ala Arg Asn Val Ser Phe 
    610                 615                 620                 


His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys Trp Asn Val Glu Phe 
625                 630                 635                 640 


Leu Gly Lys Met Phe Glu Lys Glu Thr Glu Phe Cys Leu Asp Ile Glu 
                645                 650                 655     


Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Met Phe Tyr Lys Ser Cys 
            660                 665                 670         


Asn Leu Glu Lys Met Leu Asn His Leu Tyr Ser Arg Lys Val Ser Arg 
        675                 680                 685             


Ala Ala Gln Val Pro Ser Tyr Asn Thr Val Phe Val Arg Lys Thr Phe 
    690                 695                 700                 


Pro Glu Tyr Val Asn Asn Val Leu Lys Tyr Lys Lys Pro Gly Thr Asp 
705                 710                 715                 720 


Ala Glu Ile Leu Asp Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu Leu Lys 
                725                 730                 735     


Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Lys Asp Ala Phe Lys Tyr 
            740                 745                 750         


Leu Glu Lys Ala Val Tyr Asn Leu Asn Ser Lys Asn Ile Asn His Asp 
        755                 760                 765             


Asn Ser Gly Lys Lys Ile Ser Gly Asp Glu Leu Lys Arg Lys Lys Ala 
    770                 775                 780                 


Ser Glu Ser Phe Gln Lys Arg Phe Ala Glu Ile Lys Lys Val Ser Ala 
785                 790                 795                 800 


Ser Ser Ile Ser Tyr Val Cys Gln Val Phe Met Thr Asp Tyr Asn Gln 
                805                 810                 815     


Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn Asp Ser Leu Phe 
            820                 825                 830         


Asp Lys Pro Ile Tyr Gln His Phe Lys Met Leu Leu Lys Glu Thr Ile 
        835                 840                 845             


Lys Ser Ala Phe Ala Ala Tyr Leu Lys Asp Asn Asn Asn Lys Glu Leu 
    850                 855                 860                 


Phe Gly Phe Ile Gly Glu Pro Leu Lys Ile Lys Lys Asn Asp Asp Thr 
865                 870                 875                 880 


Lys Ala Val Glu Lys Glu Asp Phe Leu Pro Gly Trp Lys Ser Glu Lys 
                885                 890                 895     


Tyr Ser Leu Leu Ile Glu Arg Val Lys Lys Ser Pro Glu Leu Gln Met 
            900                 905                 910         


Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met 
        915                 920                 925             


Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Ala Ser Asp Ile Asn Arg 
    930                 935                 940                 


Arg Ala Asn Val Met Gly Asn Lys Leu His Val Glu Val Leu Asp Lys 
945                 950                 955                 960 


Asp Lys Val Lys Glu Trp Ile Gln Val Ile Glu Val Cys Leu Leu Leu 
                965                 970                 975     


Ser Ser Arg Ile Ser Asn Gln Phe Asp Asp Tyr Phe Ile Asp Glu Asp 
            980                 985                 990         


Asp Tyr Ala Gly Tyr Leu Lys Ser  Tyr Val Asp Phe Pro  Asp Lys Asn 
        995                 1000                 1005             


Met Pro  Ser Ala Tyr Ser Ala  Leu Val Asp Phe Ser  Ala Gln Gly 
    1010                 1015                 1020             


Lys Ile  Asp Leu Tyr Val Asp  Ser Lys Asn Pro Lys  Ile Asn Arg 
    1025                 1030                 1035             


Asn Ile  Val Gln Ser Lys Leu  Phe Ala Ala Asp His  Ile Leu Gly 
    1040                 1045                 1050             


Asn Gly  Gln Ile Val Gln Leu  Val Ser Lys Asp Asp  Ile Val Glu 
    1055                 1060                 1065             


Phe Tyr  Asn Leu Lys Ala Lys  Ile Ala Asp Ser Lys  Ile Lys Gly 
    1070                 1075                 1080             


Glu Asn  Ile Ser Glu Lys Glu  Gln Arg Asn Ile Leu  Arg Tyr Gln 
    1085                 1090                 1095             


Lys Leu  Lys Asn Lys Val Glu  Leu Arg Asp Ile Val  Glu Tyr Gly 
    1100                 1105                 1110             


Glu Ile  Ile Asn Glu Leu Ile  Gly Gln Leu Ile Asn  Trp Ser Phe 
    1115                 1120                 1125             


Met Arg  Glu Arg Asp Leu Leu  Tyr Phe Gln Leu Gly  Phe His Tyr 
    1130                 1135                 1140             


Asn Cys  Leu Arg Asn Asn Ser  Glu Lys Pro Glu Glu  Tyr Lys Lys 
    1145                 1150                 1155             


Ile Glu  Ala Asp Asp Ile Ser  Ile Asn Asp Ala Val  Leu Tyr Gln 
    1160                 1165                 1170             


Ile Ile  Gly Met Tyr Val Asn  Gly Ile Pro Val Tyr  Thr Ser Asp 
    1175                 1180                 1185             


Asn Asn  Lys Leu Lys Gly Glu  Cys Ala Asn Gly Gly  Ala Gly Gly 
    1190                 1195                 1200             


Lys Ile  Ile Ala Phe Cys Lys  Tyr Ser Glu Tyr Leu  Gly Phe Lys 
    1205                 1210                 1215             


Lys Ala  Thr Leu Tyr Glu Ala  Gly Leu Glu Val Phe  Glu Val Val 
    1220                 1225                 1230             


Ala Glu  His Asp Asp Ile Ile  Lys Leu Arg Asn Gly  Ile Glu His 
    1235                 1240                 1245             


Phe Lys  Tyr Tyr Leu Gly Asn  Tyr Arg Ser Ile Met  Ser Leu Tyr 
    1250                 1255                 1260             


Ser Glu  Val Phe Asp Arg Phe  Phe Thr Tyr Asp Leu  Lys Tyr Gln 
    1265                 1270                 1275             


Lys Asn  Val Leu Asn Leu Leu  Gln Asn Ile Leu Leu  Arg His Asn 
    1280                 1285                 1290             


Val Val  Ile Val Pro Asp Phe  Glu Ser Gly Thr Lys  Lys Val Gly 
    1295                 1300                 1305             


Asp Asn  Thr Lys Gln Ala Ala  Lys Ile Ser Ile Lys  Asn Ile Gln 
    1310                 1315                 1320             


Ser Asp  Lys Phe Thr Tyr Lys  Ile Asn Gly Gly Thr  Ala Ser Ile 
    1325                 1330                 1335             


Asp Ala  Lys Asp Asp Arg Tyr  Leu Glu Thr Ile Lys  Lys Ile Leu 
    1340                 1345                 1350             


Tyr Tyr  Pro Glu Tyr Asp Lys  Asp Ser Ser Gly Val  Cys 
    1355                 1360                 1365     


<210>  489
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  489

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Pro Gly Thr Asp Thr 
            20                  25                  30          


Ile Asp Leu Lys Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Lys Val Phe Asn Gln Ile Gln Val Gly Asn Lys Pro Lys Lys 
    50                  55                  60                  


Trp Lys Lys Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Glu Tyr Val Glu Ser Ser Gln Arg Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Asp Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Cys Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Glu Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Gly Leu Phe Val Asn Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Ile Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Ser Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Tyr Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Lys Asp Arg Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Lys Glu Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Gln Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Phe 
            660                 665                 670         


Ile Arg Lys Asn Phe Pro Glu Asp Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Lys Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Tyr 
                805                 810                 815     


Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Thr 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Asp Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Asp Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asn  Ser Glu Lys Lys Glu  Ala Tyr Gln Lys Ile  Glu Val Asn 
    1100                 1105                 1110             


Gly Asp  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Val  Tyr Ala Pro Asp Glu  Lys Gly Asp 
    1130                 1135                 1140             


Ile Leu  Lys Glu Gln Cys Thr  Lys Gly Gly Ala Gly  Gly Lys Ile 
    1145                 1150                 1155             


Ser Ala  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Lys Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Lys Gln 
    1250                 1255                 1260             


Thr Thr  Ser Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Ser Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Lys  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Val Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Gly Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Pro Asn 
    1370                 1375                 1380         


<210>  490
<211>  1276
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  490

Met Lys Ile Ser Lys Val Asp His Val Lys Ser Gly Ile Asp Gln Lys 
1               5                   10                  15      


Leu Ser Ser Gln Arg Gly Met Leu Tyr Lys Gln Pro Gln Lys Lys Tyr 
            20                  25                  30          


Glu Gly Lys Gln Leu Glu Glu His Val Arg Asn Leu Ser Arg Lys Ala 
        35                  40                  45              


Lys Ala Leu Tyr Gln Val Phe Pro Val Ser Gly Asn Ser Lys Met Glu 
    50                  55                  60                  


Lys Glu Leu Gln Ile Ile Asn Ser Phe Ile Lys Asn Ile Leu Leu Arg 
65                  70                  75                  80  


Leu Asp Ser Gly Lys Thr Ser Glu Glu Ile Val Gly Tyr Ile Asn Thr 
                85                  90                  95      


Tyr Ser Val Ala Ser Gln Ile Ser Gly Asp His Ile Gln Glu Leu Val 
            100                 105                 110         


Asp Gln His Leu Lys Glu Ser Leu Arg Lys Tyr Thr Cys Val Gly Asp 
        115                 120                 125             


Lys Arg Ile Tyr Val Pro Asp Ile Ile Val Ala Leu Leu Lys Ser Lys 
    130                 135                 140                 


Phe Asn Ser Glu Thr Leu Gln Tyr Asp Asn Ser Glu Leu Lys Ile Leu 
145                 150                 155                 160 


Ile Asp Phe Ile Arg Glu Asp Tyr Leu Lys Glu Lys Gln Ile Lys Gln 
                165                 170                 175     


Ile Val His Ser Ile Glu Asn Asn Ser Thr Pro Leu Arg Ile Ala Glu 
            180                 185                 190         


Ile Asn Gly Gln Lys Arg Leu Ile Pro Ala Asn Val Asp Asn Pro Lys 
        195                 200                 205             


Lys Ser Tyr Ile Phe Glu Phe Leu Lys Glu Tyr Ala Gln Ser Asp Pro 
    210                 215                 220                 


Lys Gly Gln Glu Ser Leu Leu Gln His Met Arg Tyr Leu Ile Leu Leu 
225                 230                 235                 240 


Tyr Leu Tyr Gly Pro Asp Lys Ile Thr Asp Asp Tyr Ser Glu Glu Ile 
                245                 250                 255     


Glu Ala Trp Asn Phe Gly Ser Ile Val Met Asp Asn Glu Gln Leu Phe 
            260                 265                 270         


Ser Glu Glu Ala Ser Met Leu Ile Gln Asp Arg Ile Tyr Val Asn Gln 
        275                 280                 285             


Gln Ile Glu Glu Gly Arg Gln Ser Lys Asp Thr Ala Lys Val Lys Lys 
    290                 295                 300                 


Asn Lys Ser Lys Tyr Arg Met Leu Gly Asp Lys Ile Glu His Ser Ile 
305                 310                 315                 320 


Asn Glu Ser Val Val Lys His Tyr Gln Glu Ala Cys Lys Ala Val Glu 
                325                 330                 335     


Glu Lys Asp Ile Pro Trp Ile Lys Tyr Ile Ser Asp His Val Met Ser 
            340                 345                 350         


Val Tyr Ser Ser Lys Asn Arg Val Asp Leu Asp Lys Leu Ser Leu Pro 
        355                 360                 365             


Tyr Leu Ala Lys Asn Thr Trp Asn Thr Trp Ile Ser Phe Ile Ala Met 
    370                 375                 380                 


Lys Tyr Val Asp Met Gly Lys Gly Val Tyr His Phe Ala Met Ser Asp 
385                 390                 395                 400 


Val Asp Lys Val Gly Lys Gln Asp Asn Leu Ile Ile Gly Gln Ile Asp 
                405                 410                 415     


Pro Lys Phe Ser Asp Gly Ile Ser Ser Phe Asp Tyr Glu Arg Ile Lys 
            420                 425                 430         


Ala Glu Asp Asp Leu His Arg Ser Met Ser Gly Tyr Ile Ala Phe Ala 
        435                 440                 445             


Val Asn Asn Phe Ala Arg Ala Ile Cys Ser Asp Glu Phe Arg Lys Lys 
    450                 455                 460                 


Asn Arg Lys Glu Asp Val Leu Thr Val Gly Leu Asp Glu Ile Pro Leu 
465                 470                 475                 480 


Tyr Asp Asn Val Lys Arg Lys Leu Leu Gln Tyr Phe Gly Gly Ala Ser 
                485                 490                 495     


Asn Trp Asp Asp Ser Ile Ile Asp Ile Ile Asp Asp Lys Asp Leu Val 
            500                 505                 510         


Ala Cys Ile Lys Glu Asn Leu Tyr Val Ala Arg Asn Val Asn Phe His 
        515                 520                 525             


Phe Ala Gly Ser Glu Lys Val Gln Lys Lys Gln Asp Asp Ile Leu Glu 
    530                 535                 540                 


Glu Ile Val Arg Lys Glu Thr Arg Asp Ile Gly Lys His Tyr Arg Lys 
545                 550                 555                 560 


Val Phe Tyr Ser Asn Asn Val Ala Val Phe Tyr Cys Asp Glu Asp Ile 
                565                 570                 575     


Ile Lys Leu Met Asn His Leu Tyr Gln Arg Glu Lys Pro Tyr Gln Ala 
            580                 585                 590         


Gln Ile Pro Ser Tyr Asn Lys Val Ile Ser Lys Thr Tyr Leu Pro Asp 
        595                 600                 605             


Leu Ile Phe Met Leu Leu Lys Gly Lys Asn Arg Thr Lys Ile Ser Asp 
    610                 615                 620                 


Pro Ser Ile Met Asn Met Phe Arg Gly Thr Phe Tyr Phe Leu Leu Lys 
625                 630                 635                 640 


Glu Ile Tyr Tyr Asn Asp Phe Leu Gln Ala Ser Asn Leu Lys Glu Met 
                645                 650                 655     


Phe Cys Glu Gly Leu Lys Asn Asn Val Lys Asn Lys Lys Ser Glu Lys 
            660                 665                 670         


Pro Tyr Gln Asn Phe Met Arg Arg Phe Glu Glu Leu Glu Asn Met Gly 
        675                 680                 685             


Met Asp Phe Gly Glu Ile Cys Gln Gln Ile Met Thr Asp Tyr Glu Gln 
    690                 695                 700                 


Gln Asn Lys Gln Lys Lys Lys Thr Ala Thr Ala Val Met Ser Glu Lys 
705                 710                 715                 720 


Asp Lys Lys Ile Arg Thr Leu Asp Asn Asp Thr Gln Lys Tyr Lys His 
                725                 730                 735     


Phe Arg Thr Leu Leu Tyr Ile Gly Leu Arg Glu Ala Phe Ile Ile Tyr 
            740                 745                 750         


Leu Lys Asp Glu Lys Asn Lys Glu Trp Tyr Glu Phe Leu Arg Glu Pro 
        755                 760                 765             


Val Lys Arg Glu Gln Pro Glu Glu Lys Glu Phe Val Asn Lys Trp Lys 
    770                 775                 780                 


Leu Asn Gln Tyr Ser Asp Cys Ser Glu Leu Ile Leu Lys Asp Ser Leu 
785                 790                 795                 800 


Ala Ala Ala Trp Tyr Val Val Ala His Phe Ile Asn Gln Ala Gln Leu 
                805                 810                 815     


Asn His Leu Ile Gly Asp Ile Lys Asn Tyr Ile Gln Phe Ile Ser Asp 
            820                 825                 830         


Ile Asp Arg Arg Ala Lys Ser Thr Gly Asn Pro Val Ser Glu Ser Thr 
        835                 840                 845             


Glu Ile Gln Ile Glu Arg Tyr Arg Lys Ile Leu Arg Val Leu Glu Phe 
    850                 855                 860                 


Ala Lys Phe Phe Cys Gly Gln Ile Thr Asn Val Leu Thr Asp Tyr Tyr 
865                 870                 875                 880 


Gln Asp Glu Asn Asp Phe Ser Thr His Val Gly His Tyr Val Lys Phe 
                885                 890                 895     


Glu Lys Lys Asn Met Glu Pro Ala His Ala Leu Gln Ala Phe Ser Asn 
            900                 905                 910         


Ser Leu Tyr Ala Cys Gly Lys Glu Lys Lys Lys Ala Gly Phe Tyr Tyr 
        915                 920                 925             


Asp Gly Met Asn Pro Ile Val Asn Arg Asn Ile Thr Leu Ala Ser Met 
    930                 935                 940                 


Tyr Gly Asn Lys Lys Leu Leu Glu Asn Ala Met Asn Pro Val Thr Glu 
945                 950                 955                 960 


Gln Asp Ile Arg Lys Tyr Tyr Ser Leu Met Ala Glu Leu Asp Ser Val 
                965                 970                 975     


Leu Lys Asn Gly Ala Val Cys Lys Ser Glu Asp Glu Gln Lys Asn Leu 
            980                 985                 990         


Arg His Phe Gln Asn Leu Lys Asn  Arg Ile Glu Leu Val  Asp Val Leu 
        995                 1000                 1005             


Thr Leu  Ser Glu Leu Val Asn  Asp Leu Val Ala Gln  Leu Ile Gly 
    1010                 1015                 1020             


Trp Val  Tyr Ile Arg Glu Arg  Asp Met Met Tyr Leu  Gln Leu Gly 
    1025                 1030                 1035             


Leu His  Tyr Ile Lys Leu Tyr  Phe Thr Asp Ser Val  Ala Glu Asp 
    1040                 1045                 1050             


Ser Tyr  Leu Arg Thr Leu Asp  Leu Glu Glu Gly Ser  Ile Ala Asp 
    1055                 1060                 1065             


Gly Ala  Val Leu Tyr Gln Ile  Ala Ser Leu Tyr Ser  Phe Asn Leu 
    1070                 1075                 1080             


Pro Met  Tyr Val Lys Pro Asn  Lys Ser Ser Val Tyr  Cys Lys Lys 
    1085                 1090                 1095             


His Val  Asn Ser Val Ala Thr  Lys Phe Asp Ile Phe  Glu Lys Glu 
    1100                 1105                 1110             


Tyr Cys  Asn Gly Asp Glu Thr  Val Ile Glu Asn Gly  Leu Arg Leu 
    1115                 1120                 1125             


Phe Glu  Asn Ile Asn Leu His  Lys Asp Met Val Lys  Phe Arg Asp 
    1130                 1135                 1140             


Tyr Leu  Ala His Phe Lys Tyr  Phe Ala Lys Leu Asp  Glu Ser Ile 
    1145                 1150                 1155             


Leu Glu  Leu Tyr Ser Lys Ala  Tyr Asp Phe Phe Phe  Ser Tyr Asn 
    1160                 1165                 1170             


Ile Lys  Leu Lys Lys Ser Val  Ser Tyr Val Leu Thr  Asn Val Leu 
    1175                 1180                 1185             


Leu Ser  Tyr Phe Ile Asn Ala  Lys Leu Ser Phe Ser  Thr Tyr Lys 
    1190                 1195                 1200             


Ser Ser  Gly Asn Lys Thr Val  Gln His Arg Thr Thr  Lys Ile Ser 
    1205                 1210                 1215             


Val Val  Ala Gln Thr Asp Tyr  Phe Thr Tyr Lys Leu  Arg Ser Ile 
    1220                 1225                 1230             


Val Lys  Asn Lys Asn Gly Val  Glu Ser Ile Glu Asn  Asp Asp Arg 
    1235                 1240                 1245             


Arg Cys  Glu Val Val Asn Ile  Ala Ala Arg Asp Lys  Glu Phe Val 
    1250                 1255                 1260             


Asp Glu  Val Cys Asn Val Ile  Asn Tyr Asn Ser Asp  Lys 
    1265                 1270                 1275     


<210>  491
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  491

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Thr Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Lys Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Glu 
        755                 760                 765             


Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Lys Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Ile  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1400                 1405                 1410         


<210>  492
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  492

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Thr Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Lys Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Glu 
        755                 760                 765             


Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Lys Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Ile  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1400                 1405                 1410         


<210>  493
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  493

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Gly Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn Tyr Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Gly Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Gly Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Ser Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  494
<211>  1432
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  494

Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser Val Thr 
1               5                   10                  15      


Glu Asn Lys Asn Glu Glu Gln Leu Ser Arg Gln Ser Leu Leu Tyr Tyr 
            20                  25                  30          


Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp Leu Glu 
        35                  40                  45              


Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr Asn Val 
    50                  55                  60                  


Ile Thr Pro Glu Ile Asp Leu Cys Lys Glu Glu Asn Arg Glu Trp Ile 
65                  70                  75                  80  


Val Glu Asp Leu Thr Lys Asn Phe Asn Ala Val Ile Asn Asn Ala Leu 
                85                  90                  95      


Arg Ser Ile Lys Asn Pro Lys Glu Lys Arg Glu Glu Arg Val Glu Lys 
            100                 105                 110         


Glu Val Ala Phe Ile Leu Asn Leu Asn Lys Asn Ser Ile Lys Ile Lys 
        115                 120                 125             


Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe Ser Ala 
    130                 135                 140                 


Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser Lys Glu 
145                 150                 155                 160 


Glu Ala Tyr Ile Arg Glu Met Ile Ser Asn Leu Val Leu Arg Lys Leu 
                165                 170                 175     


Lys Lys Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Cys Lys Met 
            180                 185                 190         


Gln Met Thr Glu Ile Thr Ile Ser Leu Met Ser Ala Ile Cys Leu Tyr 
        195                 200                 205             


Gly Asn Val Glu Ser Phe Asp Pro Val Ile Leu Lys Ala Phe Phe Glu 
    210                 215                 220                 


Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile Val 
225                 230                 235                 240 


Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys Asp 
                245                 250                 255     


Gly Lys His Leu Leu Ile Pro Ala Asn Ala Asp His Arg Lys Lys Lys 
            260                 265                 270         


Tyr Val Phe Glu Phe Met Arg Lys Tyr Ala Ala Ala Glu Glu Lys Glu 
        275                 280                 285             


Lys Arg Glu Ile Thr Glu His Ile Gln Asn Leu Ile Gly Leu Tyr Leu 
    290                 295                 300                 


Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asn Met 
305                 310                 315                 320 


Thr Glu Ser His Asn Cys Ile Ser Gly Glu Ile Glu Glu Ile Phe Asn 
                325                 330                 335     


Glu Ile Glu Glu Leu Glu Asn Ser Ser Lys Gln Lys Arg Glu Glu Lys 
            340                 345                 350         


Lys Lys Thr Arg Glu Glu Leu Asp Lys Ile Gln Glu Ser Arg Lys Gly 
        355                 360                 365             


Asn Lys Arg Asn Thr Asn Ser Asn Asn Gln Asn Tyr Lys Asn Asn Lys 
    370                 375                 380                 


Thr Asp Ser Asp Lys Lys Glu Asn Gln Ala Asp Ala Asn Glu Asn Lys 
385                 390                 395                 400 


Leu Lys Glu Asn Glu Leu Arg Asp Lys Arg Arg Arg Leu Ser Lys Glu 
                405                 410                 415     


Leu Glu Asn Leu Asp Ser Glu Val Arg Ile Lys Lys Glu Lys Leu Lys 
            420                 425                 430         


Asn Thr Thr Val Lys Glu Met Ala Leu Lys Tyr Arg Ala Ala Val Asn 
        435                 440                 445             


Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile Lys Glu 
    450                 455                 460                 


Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr Ile Asp 
465                 470                 475                 480 


Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp Arg Tyr 
                485                 490                 495     


Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu Trp Thr 
            500                 505                 510         


Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val Tyr His 
        515                 520                 525             


Phe Ala Ile Pro Asp Leu Ser Gly Ala Leu Glu Gly Glu Ser Val Ser 
    530                 535                 540                 


Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly Phe Asp 
545                 550                 555                 560 


Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met Glu Lys 
                565                 570                 575     


Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr Pro Glu 
            580                 585                 590         


Glu Glu Arg Glu Lys Pro Gly His Glu Asp Val Leu Leu Met Lys Thr 
        595                 600                 605             


Leu Ser Glu Ile Glu Glu Ser Gln Thr Glu Glu Glu Arg Gln Lys Lys 
    610                 615                 620                 


His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp Ala Asp 
625                 630                 635                 640 


Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg Lys Lys 
                645                 650                 655     


Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr Lys Glu 
            660                 665                 670         


Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His Tyr Thr 
        675                 680                 685             


Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Glu Leu Thr Glu Tyr 
    690                 695                 700                 


Phe Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg Glu Lys 
705                 710                 715                 720 


Tyr Tyr Thr Asn Asn Val Trp Lys Tyr Tyr Asp Ile Glu Val Ile Asn 
                725                 730                 735     


Asn Ile Met Gly Lys Ile Tyr Cys Gly Arg Lys Tyr Arg Ala Ala Gln 
            740                 745                 750         


Val Pro Ala Phe Asn Asn Ile Ile Ser Arg Pro Ala Leu Pro Gln Leu 
        755                 760                 765             


Met Asp Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met Asn Cys 
    770                 775                 780                 


Pro Asp Arg Asp Val Ile Lys Lys Tyr Trp Ser Ser Leu Phe Phe Val 
785                 790                 795                 800 


Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Glu Lys Pro 
                805                 810                 815     


Glu Asp Asn Ile Lys Glu Arg Phe Phe Arg Ala Met Glu Lys Glu Ser 
            820                 825                 830         


Gly Gln Ala Lys Asp Gly Lys Glu Gln Lys Ala Trp Glu Ser Phe Glu 
        835                 840                 845             


Asn Arg Ile Asp Gln Ile Gly Arg Glu Arg Ser Phe Gly Ala Ile Cys 
    850                 855                 860                 


Gln Gly Leu Met Val Glu Tyr Met Leu Gln Asn Arg Asp Ile Ser Met 
865                 870                 875                 880 


Val Gln Thr Glu Thr Gly Asp Gly Lys Thr Asn Lys Lys Gln Ile Tyr 
                885                 890                 895     


Lys His Tyr Arg Thr Leu Leu Tyr Ile Cys Ile Arg Ser Ala Phe Thr 
            900                 905                 910         


Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro Val Leu Thr 
        915                 920                 925             


Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Gln Thr Asp Gly Leu Lys 
    930                 935                 940                 


His Leu Ser Leu Phe Asp His Leu Lys Glu Thr Phe Asn Asp Ala Glu 
945                 950                 955                 960 


Ser Gly Ser Phe Trp Tyr Met Ala Ala His Phe Ile Asn Gln Lys Tyr 
                965                 970                 975     


Leu Asn His Leu Ile Gly Ser Ile Arg Asn Tyr Leu Gln Phe Thr Glu 
            980                 985                 990         


Asp Ile Glu Asp Arg Ala Leu Ser  Leu Gly Asp Cys Val  Asp Asn Lys 
        995                 1000                 1005             


Arg Glu  Glu Lys Asn Leu Arg  Tyr Arg Asn Thr Leu  Glu Ile Leu 
    1010                 1015                 1020             


Glu Phe  Val Ala Gln Phe Cys  Glu Arg Thr Thr Asn  Val Met Glu 
    1025                 1030                 1035             


Asp Tyr  Phe Glu Ser Asn Gln  Glu Tyr Ala Ala Tyr  Leu Ser Gly 
    1040                 1045                 1050             


Phe Val  Asp Tyr Asn Val Ser  Lys Lys Glu Thr Asp  Ile Glu Lys 
    1055                 1060                 1065             


Ala Leu  Tyr Gly Phe Cys Arg  Gln Lys Phe Lys Val  Asp Gly Lys 
    1070                 1075                 1080             


Glu Tyr  Met Ala Gly Ile Tyr  Tyr Asp Gly Glu Asn  Leu Ile Pro 
    1085                 1090                 1095             


Asn Arg  Asn Ile Ile Arg Ala  Asn Met Tyr Gly Asn  Val Ser Cys 
    1100                 1105                 1110             


Leu Lys  Pro Tyr Met Asp Arg  Ile Thr Leu Lys Glu  Ile Arg Thr 
    1115                 1120                 1125             


Met Tyr  Ala Asp Gln Asn Lys  Leu Asp Thr Val Leu  Lys Glu Gly 
    1130                 1135                 1140             


Val Cys  Arg Thr Glu Glu Glu  Gln Lys Ala Tyr Arg  Glu Tyr Gln 
    1145                 1150                 1155             


Asn Glu  Lys Asn Arg Ile Glu  Leu Phe Asp Leu Cys  Thr Tyr Thr 
    1160                 1165                 1170             


Gln Ile  Leu Asn Asp Ile Gln  Ala Lys Leu Ile Gly  Trp Ser Tyr 
    1175                 1180                 1185             


Met Arg  Glu Arg Asp Leu Met  Tyr Tyr Gln Leu Gly  Tyr Tyr Tyr 
    1190                 1195                 1200             


Thr Lys  Leu Phe Trp Thr Asp  Ser Ile Ser Glu Glu  Asp Ala Arg 
    1205                 1210                 1215             


Arg Arg  Leu Met Gly Glu Leu  Val Asn Val Glu Asp  Gly Val Ile 
    1220                 1225                 1230             


Leu Tyr  Gln Ile Leu Ala Phe  Asn Ser Tyr Asn Leu  Pro Ile Ile 
    1235                 1240                 1245             


Ala Asn  Lys Asn Asn Thr Val  Thr Phe Leu Lys Gly  Glu Gly Ser 
    1250                 1255                 1260             


Ile Gly  Gly Lys Ala Ile Thr  Ala Phe Leu Lys Asn  Tyr Glu Asn 
    1265                 1270                 1275             


Ala Glu  Arg Ile Tyr Glu Glu  Ala Leu Asp Leu Phe  Glu Asn Thr 
    1280                 1285                 1290             


Asp Glu  His Ala Ala Ile Ile  Asn Thr Arg Asn Tyr  Ile Glu His 
    1295                 1300                 1305             


Phe Lys  Tyr Phe Ile Lys Ser  Asp Arg Ser Met Met  Asp Leu Tyr 
    1310                 1315                 1320             


Ser Glu  Val Tyr Asp Arg Phe  Phe Arg His Asp His  Asn Arg Lys 
    1325                 1330                 1335             


Lys Asn  Val Pro Asp Ser Leu  Lys Asn Val Leu Ala  Asp Asn Phe 
    1340                 1345                 1350             


Met Ile  Ala Asp Ile Ser Met  Glu Leu Gly Ser Lys  Lys Val Gly 
    1355                 1360                 1365             


Glu Lys  Lys Lys Gly Phe Arg  Glu His Lys Ala Ala  Arg Ile Glu 
    1370                 1375                 1380             


Phe Thr  Asp Arg Gly Ile Arg  Ser Thr Asp Met Thr  Tyr Thr Val 
    1385                 1390                 1395             


Lys Pro  Asp Pro Lys Asp Ser  Lys Lys Asp Glu Lys  Val Leu Val 
    1400                 1405                 1410             


Pro Ala  Arg Ser Glu Val Phe  Leu Lys Gln Phe Gln  Lys Ile Leu 
    1415                 1420                 1425             


Glu Tyr  Arg Ile 
    1430         


<210>  495
<211>  1299
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  495

Val Lys Val Thr Lys Val Asn Ser Ala Arg Val Ala Val Val Ser Lys 
1               5                   10                  15      


Lys Leu Lys Asn Ser Arg Ala Val Leu Tyr Ala Thr Thr Ala Asn Lys 
            20                  25                  30          


Gly Val Ser Glu Asp Ser Glu Ser Phe Ile Val Lys Arg Ile Asp Ala 
        35                  40                  45              


Ala Asn Arg Leu Tyr Gly Val Phe Phe Arg Gly Asn Asn Lys Thr Val 
    50                  55                  60                  


Pro Leu Pro Asn Gly Ile Glu Asn Lys Phe Thr Gln Leu Leu Asn Tyr 
65                  70                  75                  80  


Met Glu Tyr Glu His Arg Gly Lys Ile Leu Ala Ala Tyr Arg Thr Gly 
                85                  90                  95      


Asp Ala Ser Gln Ile Asn Gln Cys Val Asp Asp Gln Ile Ala Trp Leu 
            100                 105                 110         


Lys Lys Ile Gln Ile Ile Lys Arg Val Lys Trp Lys Ser Lys Ala Glu 
        115                 120                 125             


Lys Tyr Tyr Val Asp Asp Lys Asp Ser Ile Lys Arg Ile Asp Phe Lys 
    130                 135                 140                 


Thr Gln Lys Asp Ile Ser Glu Asp Val Leu Asp Asp Ala Ile Lys Arg 
145                 150                 155                 160 


Met Arg Lys Ser Leu Lys Arg Gly Ser Asn Arg Trp Ile Val Lys Arg 
                165                 170                 175     


Leu Ile Arg Ala Leu Ala Gln Gly Asp Glu Thr Val Tyr Ile Thr Val 
            180                 185                 190         


Leu Glu Asp Ala Ala Phe Pro Lys Phe Val Asp Ala Val Asn Lys Asp 
        195                 200                 205             


Tyr Tyr Lys Thr Asn Leu Leu Arg Ser Leu Ala Arg His Asp Val Lys 
    210                 215                 220                 


Val Gln Val His Ser Asp Tyr Ile Leu Asp Leu Ala Ser Val Asp Asn 
225                 230                 235                 240 


Ala Lys Ala Asn Lys Lys Ala Leu Thr Gln Ile Leu Glu Lys Tyr Ala 
                245                 250                 255     


Ser Ser Glu Lys Ala Ala Thr Glu Thr Leu Leu Glu Met Lys Arg Ile 
            260                 265                 270         


Phe Phe Ala Tyr Phe Phe Ser Phe Asp Asp Glu Lys Tyr Gly Lys Phe 
        275                 280                 285             


Phe Ala Ser Glu Asn Leu Trp Lys Val Pro Ser Glu Thr Ile Gln Glu 
    290                 295                 300                 


Asp Val Gly Gly Tyr Phe Asp Glu Gly Phe Ile Pro Leu Asp Gly Tyr 
305                 310                 315                 320 


Ala Asp Lys Phe Asp Tyr Thr Ile Glu Asp Leu Thr Arg Glu Lys Pro 
                325                 330                 335     


Leu Asn Ile Gly Lys Leu Lys Ala Arg Val Arg Phe Val Asn Phe Gly 
            340                 345                 350         


Lys Tyr Leu Gln Met Met Ser Gln Asp Asn Tyr Asn Gly Asp Glu Ile 
        355                 360                 365             


Ala Gln Tyr Trp Ile Asn Tyr Ala Lys Glu Tyr Val Glu Glu Asn Tyr 
    370                 375                 380                 


Gln Ala Lys Asp Tyr Lys Asn Arg Lys Val Asp Ile Asp Ser Tyr Lys 
385                 390                 395                 400 


Arg Ile Arg Met Phe Lys Ala Cys Trp Lys Asp Ala Val Arg Phe Ile 
                405                 410                 415     


Cys Gly Lys Tyr Ile Asp Leu Gly Lys Ala Val Tyr His Phe Ala Met 
            420                 425                 430         


Pro Lys Lys Leu Ser Glu Lys Leu Glu Ser Gly Asn Glu Tyr Gly Arg 
        435                 440                 445             


Ile Arg Glu Glu Tyr Arg Asn Gly Ile Ser Ser Phe Ala Tyr Glu Ala 
    450                 455                 460                 


Ile Lys Ala Glu Glu Thr Leu Gln Arg Asn Ile Ala Asn Ala Thr Val 
465                 470                 475                 480 


Ala Ala Leu Ser Ala Phe Ser Arg Ser Val Leu Asp Tyr Ser Lys Gln 
                485                 490                 495     


Ser Glu Ala Gly Lys Glu Asp Ile Leu Phe Met Ser Lys Asp Gln Leu 
            500                 505                 510         


Lys Asn Leu Arg Lys Glu Asp Val Leu Lys Pro Ile Leu Arg Tyr Tyr 
        515                 520                 525             


Gly Gly Gln Ser Glu Val Lys Ala Phe Asp Leu Asn Gly Ile Ala Leu 
    530                 535                 540                 


Met Glu Glu Ile Met Gly His Phe Ser Leu Ile Arg Asn Glu Asn Phe 
545                 550                 555                 560 


His Tyr Ala Pro Gly Lys Leu Gly Glu Ile Lys Tyr Glu Asn Ser Leu 
                565                 570                 575     


Lys Leu Trp Gln Asn Asp Val Asp Val Tyr Ala Gln Val Val Arg Gln 
            580                 585                 590         


Lys Tyr Tyr Ser Asn Asn Thr Ala Val Phe Tyr Gly Lys Glu Asn Ile 
        595                 600                 605             


Thr Lys Leu Phe Thr Ala Leu His Gly Lys Lys Arg Val Ser Ala Ser 
    610                 615                 620                 


Gln Ile Pro Ala Phe Arg Ser Ile Trp Arg Arg Gln Glu Ile Ser Ala 
625                 630                 635                 640 


Phe Val Lys Val Ile Glu Lys Lys Ala Ala Lys Ala Lys His Glu Cys 
                645                 650                 655     


Ser Phe Leu Asn Asn Glu Glu Glu Arg Ile Lys Tyr Glu Gly Ala Leu 
            660                 665                 670         


Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Asn Asp Phe Ile Phe Leu Asp 
        675                 680                 685             


Tyr Lys Ala Arg Asp Tyr Phe Val Lys Ala Val Asn Asp Tyr Thr Gly 
    690                 695                 700                 


Thr Asp Gly Ile Ala Gln Ser Thr Gln Ala Ala Asn Asn Phe Lys Glu 
705                 710                 715                 720 


Tyr Val Gly Asn Leu Ala Gly Leu Asn Leu Thr Phe Ala Gln Ile Cys 
                725                 730                 735     


Gln Lys Ile Gln Gln Glu Tyr Asn Gln Gln Asn Thr Asn Ala Lys Lys 
            740                 745                 750         


Ser Gly Lys Thr Glu Glu Ser Tyr Ala His Phe Lys Met Leu Leu Pro 
        755                 760                 765             


Met Cys Val Lys Ser Ala Phe Gln Gln Tyr Leu Ala Asp Asn Tyr Lys 
    770                 775                 780                 


Phe Leu Phe Lys Pro Glu Phe Asn Glu Ala Leu Glu Asp Glu Gln Asp 
785                 790                 795                 800 


Tyr Leu Asp Glu Val Leu Val Asp Cys Gly Val Ala Ile Lys Gly Ile 
                805                 810                 815     


Pro Asp Asn Asp Lys Glu Lys Arg Arg Leu Ala Trp Phe Thr Phe Ala 
            820                 825                 830         


His Phe Val His Pro Lys Gln Leu Asn Leu Leu Ile Gly Asp Phe Lys 
        835                 840                 845             


Ser Tyr Ile Gln Tyr Arg Asn Asp Val Phe Lys Arg Ala Gly Phe Ala 
    850                 855                 860                 


Asp Glu Tyr Gly Ser Ala Glu Glu Lys Asp Arg Ala Glu Lys Glu Lys 
865                 870                 875                 880 


Asp Val Ser Ile Lys Arg Ala Lys Ser Ile Leu Asp Val Leu Glu Phe 
                885                 890                 895     


Val Arg Pro Ile Ala Gly Arg Val Ser Asn Val Phe Asp Asp Tyr Tyr 
            900                 905                 910         


Asp Asn Glu Asp Glu Tyr Ala Arg Tyr Leu Ser Asn Tyr Ile Thr Phe 
        915                 920                 925             


Ser Ser Lys Asn Glu Glu Pro Thr Phe Lys Asn Leu Lys Leu Phe Cys 
    930                 935                 940                 


Glu Asn Thr Leu Ala Asp Gly Ala Met Val Asp Ile Tyr Ala Asp Lys 
945                 950                 955                 960 


Ala Asn Pro Lys Val Leu Arg Asn Val Glu Ile Ala Arg Met Tyr Ala 
                965                 970                 975     


Gly Gly Asp Val Ile Leu Asn Gly Ile Glu Lys Val Asp Ala Lys Lys 
            980                 985                 990         


Val Arg Lys Tyr Tyr Glu Asn Lys  Ala Ala Ala Leu Glu  Leu Gln Lys 
        995                 1000                 1005             


Lys Gly  Leu Cys Ala Asn Glu  Glu Glu Gln Arg Lys  Ile Ile Lys 
    1010                 1015                 1020             


Gln Gln  Gln Leu Lys Gly Gln  Leu Met Leu Asn Asp  Val Thr Glu 
    1025                 1030                 1035             


Thr Phe  Ser Leu Val Asn Asp  Met Leu Gly Gly Leu  Val Ser Leu 
    1040                 1045                 1050             


Ser Tyr  Leu Arg Glu Arg Asp  Lys Met Tyr Leu Leu  Leu Gly Tyr 
    1055                 1060                 1065             


Tyr Tyr  Met Ala Leu Arg Asn  Val Ser Asn Trp Ser  Asn Glu Lys 
    1070                 1075                 1080             


Leu Asp  Ser Val Val Glu Asp  Asp Ile Asn Ile Lys  Ser Gly Phe 
    1085                 1090                 1095             


Val Leu  Tyr Gln Val Val Ser  Met Phe Asp Tyr Gly  Thr Ser Phe 
    1100                 1105                 1110             


Leu Tyr  Phe Asp Ser Glu Lys  Asn Lys Trp Leu Glu  Met Val Asn 
    1115                 1120                 1125             


Ala Ser  Ile Asn Leu Lys Gly  Arg Lys Phe Gly Glu  Met His Ala 
    1130                 1135                 1140             


Ala Ser  Arg Ala Cys Ala Ile  Gln Leu Phe Glu Met  Asp Glu Gln 
    1145                 1150                 1155             


Ala Lys  Asp Lys Lys Gln Lys  Lys Pro Asp Thr Gln  Asp Lys Lys 
    1160                 1165                 1170             


Asp Lys  Glu Met Ser Val Arg  Glu Leu Arg Asn Tyr  Val Asp His 
    1175                 1180                 1185             


Phe Lys  Tyr Tyr Val Lys Phe  Asp Lys Ser Ile Val  Glu Leu Tyr 
    1190                 1195                 1200             


Ala Glu  Phe Tyr Thr Lys Phe  Phe Val Tyr Ser Thr  Lys Leu Arg 
    1205                 1210                 1215             


Lys Ser  Val Ile Val Asn Phe  Ser Asn Ile Leu Glu  Arg Tyr Phe 
    1220                 1225                 1230             


Leu Glu  Asn Ser Asn Ser Phe  Thr Val Leu Glu Asp  Asn Lys Thr 
    1235                 1240                 1245             


Glu Ile  Asn Leu Leu Ser Thr  Leu Lys Ser Gln Gln  Phe Thr Tyr 
    1250                 1255                 1260             


Lys Leu  Asn Ala Lys Asp Asn  Lys Gly Lys Gln Leu  Thr Cys Asn 
    1265                 1270                 1275             


Leu Asn  Ala Lys Ser Ala Asn  Phe Val Lys Ser Val  Lys Glu Val 
    1280                 1285                 1290             


Leu Lys  Tyr Lys Lys Cys 
    1295                 


<210>  496
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  496

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Gly Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Ile Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Trp Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Asn Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Phe Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Ile His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Ile  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Arg Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  497
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  497

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Asp Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Lys Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  498
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  498

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Gly Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Trp Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Asn Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Phe Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Ile His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Ile  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Arg Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  499
<211>  949
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  499

Met Pro His Gln Lys Lys Met Ala Glu Arg Ile Lys Phe Val Asn Tyr 
1               5                   10                  15      


Gly Tyr Tyr Leu Arg Leu Lys Lys Asn Cys Ala Asp Ser Phe Glu Tyr 
            20                  25                  30          


Tyr Trp Cys Asp Tyr Ile Lys Glu Phe Ile Glu Glu Asn Tyr Val Thr 
        35                  40                  45              


Lys Ile Lys Glu Ala Lys Gly Lys Asn Gly Arg Gln Leu Thr Glu Glu 
    50                  55                  60                  


Asn Cys Asn Ser Glu Ala Met Leu Ser Lys Cys Trp His Asp Met Ile 
65                  70                  75                  80  


Arg His Met Cys Ala Lys Tyr Met Asp Leu Gly Lys Ala Val Tyr His 
                85                  90                  95      


Phe Met Leu Pro Gly Lys Ala Glu Gly Asn Asp Leu Cys Leu Asp Arg 
            100                 105                 110         


Leu Asn Asp Ser Phe Ser Lys Gly Ile Thr Ser Phe Asp Tyr Glu Asn 
        115                 120                 125             


Ile Lys Ala Glu Glu Asn Leu Gln Lys Ala Met Phe Gly Val Leu Val 
    130                 135                 140                 


Ser Gly Thr Phe Asn Phe Ser Arg Ser Val Ala Asp Tyr Ser Gly Pro 
145                 150                 155                 160 


Ala Ala Ala Lys Leu Ala Lys Glu Leu Arg Ala Glu Gly Lys Thr Leu 
                165                 170                 175     


Asn Glu Asp Val Leu Met Val Asp Glu Ala His Leu Lys Ala Ile Leu 
            180                 185                 190         


Tyr Ser Asp Ala Lys Arg Lys Leu Leu Arg Tyr Phe Gly Gly Ser Ser 
        195                 200                 205             


Ala Cys Glu Ala Leu Gly Leu Asp Lys Asp Lys Met Val Leu Glu Phe 
    210                 215                 220                 


Arg Gln Ile Phe Arg Gly Leu Arg Asn Ser Ala Phe His Tyr Thr Asp 
225                 230                 235                 240 


Gly Lys Lys Ala Asp Ile Lys Phe Asp Val Thr Arg Gln Leu Trp Ile 
                245                 250                 255     


Gln Asp Val Gln Ala Asn Lys Gln Leu Ile Leu Asp Lys Tyr Tyr Ser 
            260                 265                 270         


Asn Asn Val Cys Arg Tyr Tyr Lys Pro Glu Met Val Lys Lys Leu Ile 
        275                 280                 285             


Gly Asn Leu Tyr His Gly Tyr Val Glu Gln Glu Ala Gln Ile Pro Ala 
    290                 295                 300                 


Phe Arg Thr Val Trp Lys Arg Lys Asp Phe Ala Lys Tyr Leu Asn Asp 
305                 310                 315                 320 


Ser Asn Phe Leu Pro Val Asn Ile Lys Asn Asp Val Lys Glu Arg Thr 
                325                 330                 335     


Val Phe Glu Gly Ala Leu Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg 
            340                 345                 350         


Lys Tyr Thr Val Gly Gln Asp Ala Pro Lys Tyr Phe Phe Glu Ala Val 
        355                 360                 365             


Arg Ala Tyr Ser Asp Glu His Ala Lys Asn Lys Gln Asp Pro Tyr Ala 
    370                 375                 380                 


Asn Gln Ala Lys Asn Phe Trp Asp Tyr Val Glu Lys Leu Gln Lys Ser 
385                 390                 395                 400 


Tyr Glu Lys Gly Thr Leu Thr Phe Gly Ala Val Cys Gln Thr Ile Met 
                405                 410                 415     


Thr Glu Phe Val Gln Gln Asn Ser Lys Ala Thr Glu Lys Glu Gly Glu 
            420                 425                 430         


Ile Tyr Gln His Phe Lys Val Leu Phe Pro Leu Cys Met Gln Arg Gly 
        435                 440                 445             


Phe Glu Lys Tyr Val Lys Glu Lys His Gly Tyr Leu Leu Lys Pro Trp 
    450                 455                 460                 


Leu Asp Thr Val Val Arg Glu Asn Val Leu Gln Asp Ala Ala Ile Thr 
465                 470                 475                 480 


Cys Phe Asp Asp Leu Met Arg Asp Ala Glu Asp Arg Glu Tyr Ser Trp 
                485                 490                 495     


Tyr Val Val Ala His Phe Ile His Pro Lys Lys Leu Asn His Phe Val 
            500                 505                 510         


Gly Ala Leu Lys Asp Tyr Leu Gln Phe Lys Gln Asp Ile Phe Arg Arg 
        515                 520                 525             


Cys Ser Phe Ala Asn Ile Tyr Ser Glu Gly Glu Leu Ser Gln Lys Lys 
    530                 535                 540                 


Ala Met Leu Ala Glu Lys Glu Ala Glu Ile Ser Glu Ile Leu Arg Val 
545                 550                 555                 560 


Met Glu Phe Val Arg Gly Ile Thr Gly Arg Val Ser Lys Thr Phe Ser 
                565                 570                 575     


Asp Tyr Tyr Glu Asn Glu Glu Val Tyr Ala Asn Tyr Leu Gly Lys Tyr 
            580                 585                 590         


Ile Asp Phe Pro Lys Thr Asp Gly Ile Ser Val Phe Glu Ser Phe Arg 
        595                 600                 605             


Asp Phe Cys Thr Asn Thr Leu Pro Asp Gly Asn Val Leu Asp Val Tyr 
    610                 615                 620                 


Met Asp Glu Lys Asn Pro Arg Leu Leu Lys Asn Val Glu Leu Ala Arg 
625                 630                 635                 640 


Met Tyr Ala Gly Gly Asp Val Ala Leu Lys Lys Arg Lys Arg Ile Thr 
                645                 650                 655     


Ala Lys Asp Leu Gln Arg Tyr Tyr Gly Asn Glu Val Ala Val Gln Lys 
            660                 665                 670         


Ile Leu Gln Lys Gly Leu Cys Ser Thr Arg Glu Glu Gln Gln Arg Val 
        675                 680                 685             


Leu Glu Gln Gln Asn Leu Arg Gly Arg Ile Thr Leu Asn Asp Val Thr 
    690                 695                 700                 


Glu Ile Gln Glu Ile Ile Ser Asp Met Leu Ser Gln Leu Val Thr Phe 
705                 710                 715                 720 


Ser Tyr Phe Arg Glu Arg Asp Gln Met Tyr Leu Leu Leu Gly Phe Tyr 
                725                 730                 735     


Tyr Met Ala Leu Gln Thr Asn Arg Gly Ser Ser Trp Gly Asn Glu Thr 
            740                 745                 750         


Ile Asp Phe Cys Ala Gly Lys Lys Ile Ser Ile Lys Gln Gly Trp Val 
        755                 760                 765             


Leu His Gln Val Arg Ser Val Phe Thr Tyr Gly Leu Lys Leu Tyr Ser 
    770                 775                 780                 


Glu Leu Asp Glu Lys Gly Val Gly Gly Gln Leu Ser Ser Lys Ile Val 
785                 790                 795                 800 


Ala Phe Glu Arg Val His Arg Thr Ser Leu Ala Cys Ala Leu Arg Leu 
                805                 810                 815     


Phe Met Asp Glu Asn Cys Ser Arg Arg Ala Val Asp Val Arg Asn Tyr 
            820                 825                 830         


Val Asp His Phe Lys Tyr Tyr Phe Lys Ala Asp Arg Ser Ile Met Glu 
        835                 840                 845             


Leu Tyr Ser Ala Tyr Tyr Asp Cys Phe Phe Asp Tyr Ser Thr Lys Met 
    850                 855                 860                 


Arg Lys Ser Val Leu Leu Asn Phe Ile Ser Ile Leu Glu Arg His Phe 
865                 870                 875                 880 


Val Val Ser Lys Leu Arg Val Asn Cys Leu Glu Glu Arg Cys Ser Val 
                885                 890                 895     


Ser Phe Ala Glu Ser Leu Lys Ser Glu Lys Phe Thr Tyr Lys Leu Glu 
            900                 905                 910         


Ala Asp Ala Asn Lys Lys Ser Lys Glu Gln Thr Val Glu Phe Pro Ala 
        915                 920                 925             


Arg Asp Lys Glu Phe Leu Glu Ser Leu Gln Ala Glu Leu Glu Tyr Lys 
    930                 935                 940                 


Glu Gly Tyr Asn Ser 
945                 


<210>  500
<211>  1366
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  500

Met Lys Leu Ser Lys Glu Asn His Ile Lys Ser Ala Val Ala Ile Ser 
1               5                   10                  15      


Gly Lys Glu Gly Asn Ile Ala Gly Thr Leu Tyr Lys Ile Pro Gly Glu 
            20                  25                  30          


Gly Thr Val Asp Leu Lys Lys Gln Met Leu Glu Arg Asp Lys Ala Val 
        35                  40                  45              


Lys Arg Leu Tyr Asn Ile Phe Asn Gln Ile Gln Leu Gly Thr Gln Pro 
    50                  55                  60                  


Lys Glu Trp Lys Glu Asn Arg Asn Leu Ser Ala Glu Glu Asn Thr Arg 
65                  70                  75                  80  


Arg Met His Gln Gln Ala Val Lys Ile Gln Asn Tyr Lys Met Lys Lys 
                85                  90                  95      


Ala Cys Ser Lys Tyr Val Asn Ser Ile Arg Lys Thr Ile Asn Gly Leu 
            100                 105                 110         


Leu Phe Tyr Asp Arg Ile Ile Lys Thr Thr Gln Gln Asn Lys Val Lys 
        115                 120                 125             


Ser Asp Arg Leu Lys Met Met Arg Lys Asn Glu Asp Ile Ile Ser Lys 
    130                 135                 140                 


Met Lys Asn Glu Asn Ile Leu Gln Gln Phe Lys Val Glu Gly Glu Asn 
145                 150                 155                 160 


Gly Lys Phe Glu Lys Gly Lys Leu Glu Asp Phe Val Thr Leu Ala Leu 
                165                 170                 175     


Arg Ser Ser Leu Ile Val Ser Arg Tyr Lys Gly Lys Asp Phe Asn Ser 
            180                 185                 190         


Val Ala Ala Val Val Val Phe Leu Asp Asn Ile Gly Asn Asn Asn Ile 
        195                 200                 205             


Ser His Glu Asp Glu Arg Thr Ile Asn Ile Leu Leu Asn Leu Ile Arg 
    210                 215                 220                 


Glu Asp Phe Thr Lys Leu Asn Pro Asn Lys Asp Asn Thr Gln Gly Ala 
225                 230                 235                 240 


Arg Leu Ile Arg Ser Val Thr Asn Gln Asn Met Leu Val Gln Pro Gln 
                245                 250                 255     


Asn Asp Arg Phe Ser Phe Pro Ser Val Ser Asp Ser Gly Lys Ser Lys 
            260                 265                 270         


Val Ser Asn Lys Asn Val Glu Lys Ser Gly Leu Asp Asn Phe Leu Leu 
        275                 280                 285             


Asp Tyr Ala Asn Leu Asn Lys Glu Glu Arg Glu Glu Lys Leu Arg Lys 
    290                 295                 300                 


Leu Arg Arg Ile Ile Asp Val Tyr Phe Ser Ala Pro Ile Thr Tyr Gln 
305                 310                 315                 320 


Lys Asp Met Asp Val Thr Leu Ser Glu Glu Val Val Lys Tyr Lys Phe 
                325                 330                 335     


Asp Val Trp Ile Lys His Asn Gln Gly Lys Lys Asp Asn Asn Met Phe 
            340                 345                 350         


Val Asp Val Pro Asp Val Leu Val Lys Ala Glu Thr Asp Gly Glu Lys 
        355                 360                 365             


Ile Asp Ala Val Ile Glu Lys Gln Ala Arg Lys Glu Leu Thr Asp Arg 
    370                 375                 380                 


Val Arg Glu Gln Asn Met Ile Cys Tyr Arg Tyr Thr Gln Ala Ile Val 
385                 390                 395                 400 


Lys Lys Tyr Asn Ala Asn Glu Ala Leu Phe Phe Glu Asn Asp Asp Ile 
                405                 410                 415     


Asn Gln Tyr Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu 
            420                 425                 430         


Lys Ser Cys Lys Ile Gly Thr Leu Phe Lys Leu Arg Lys Gly Tyr Leu 
        435                 440                 445             


Thr Glu Lys Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr 
    450                 455                 460                 


Ile Ala Ile Gly Lys Val Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp 
465                 470                 475                 480 


Asn Asp Asn Lys Val Lys Lys Leu Gly Asp Ile Ser Glu Lys Ile Arg 
                485                 490                 495     


Ser Gly Ile Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Thr 
            500                 505                 510         


Leu Gln Arg Glu Leu Ala Val Asn Val Ala Phe Ser Ala Asn Asn Leu 
        515                 520                 525             


Ala Arg Ala Val Cys Asp Met Ser Asn Leu Ser Asp Lys Thr Ser Asp 
    530                 535                 540                 


Phe Leu Leu Trp Lys Pro Asp Asp Ile Asn Asp Lys Met Lys Lys Ser 
545                 550                 555                 560 


Thr Gly Asn Asp Asp Asp Asn Glu Lys Asn Lys Lys Ala Val Cys Ala 
                565                 570                 575     


Val Leu Gln Phe Phe Gly Gly Lys Ser Leu Trp Lys Asp Val Asp Phe 
            580                 585                 590         


Glu Lys Ala Tyr Lys Asn Ala Gly Lys His Gly Tyr Gly Val Tyr Tyr 
        595                 600                 605             


Ile Asn Asp Leu Arg Lys Ala Ile Phe Ala Ala Arg Asn Val Ser Phe 
    610                 615                 620                 


His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys Trp Asn Val Glu Phe 
625                 630                 635                 640 


Leu Gly Lys Met Phe Glu Lys Glu Thr Glu Phe Cys Leu Asp Ile Glu 
                645                 650                 655     


Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Met Phe Tyr Lys Ser Cys 
            660                 665                 670         


Asn Leu Glu Lys Met Leu Asn His Leu Tyr Ser Arg Lys Val Ser Arg 
        675                 680                 685             


Ala Ala Gln Val Pro Ser Tyr Asn Thr Val Phe Val Arg Lys Thr Phe 
    690                 695                 700                 


Pro Glu Tyr Val Asn Asn Val Leu Lys Tyr Lys Lys Pro Gly Thr Asp 
705                 710                 715                 720 


Ala Glu Ile Leu Asp Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu Leu Lys 
                725                 730                 735     


Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Lys Asp Ala Phe Lys Tyr 
            740                 745                 750         


Leu Glu Lys Ala Val Tyr Asn Leu Asn Ser Lys Asn Ile Asn His Asp 
        755                 760                 765             


Asn Ser Gly Lys Lys Ile Ser Gly Asp Glu Leu Lys Arg Lys Lys Ala 
    770                 775                 780                 


Ser Glu Ser Phe Gln Lys Arg Phe Ala Glu Ile Lys Lys Val Ser Ala 
785                 790                 795                 800 


Ser Ser Ile Ser Tyr Val Cys Gln Val Phe Met Thr Asp Tyr Asn Gln 
                805                 810                 815     


Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn Asp Ser Leu Phe 
            820                 825                 830         


Asp Lys Pro Ile Tyr Gln His Phe Lys Met Leu Leu Lys Glu Thr Ile 
        835                 840                 845             


Lys Ser Ala Phe Ala Ala Tyr Leu Lys Asp Asn Asn Asn Lys Glu Leu 
    850                 855                 860                 


Phe Gly Phe Ile Gly Glu Pro Leu Lys Ile Lys Lys Asn Asp Asp Thr 
865                 870                 875                 880 


Lys Ala Val Glu Lys Glu Asp Phe Leu Pro Gly Trp Lys Ser Glu Lys 
                885                 890                 895     


Tyr Ser Leu Leu Ile Glu Arg Val Lys Lys Ser Pro Glu Leu Gln Met 
            900                 905                 910         


Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met 
        915                 920                 925             


Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Ala Ser Asp Ile Asn Arg 
    930                 935                 940                 


Arg Ala Asn Val Met Gly Asn Lys Leu His Val Glu Val Leu Asp Lys 
945                 950                 955                 960 


Asp Lys Val Lys Glu Trp Ile Gln Val Ile Glu Val Cys Leu Leu Leu 
                965                 970                 975     


Ser Ser Arg Ile Ser Asn Gln Phe Asp Asp Tyr Phe Ile Asp Glu Asp 
            980                 985                 990         


Asp Tyr Ala Gly Tyr Leu Lys Ser  Tyr Val Asp Phe Pro  Asp Lys Asn 
        995                 1000                 1005             


Met Pro  Ser Ala Tyr Ser Ala  Leu Val Asp Phe Ser  Ala Gln Gly 
    1010                 1015                 1020             


Lys Ile  Asp Leu Tyr Val Asp  Ser Lys Asn Pro Lys  Ile Asn Arg 
    1025                 1030                 1035             


Asn Ile  Val Gln Ser Lys Leu  Phe Ala Ala Asp His  Ile Leu Gly 
    1040                 1045                 1050             


Asn Gly  Gln Ile Val Gln Leu  Val Ser Lys Asp Asp  Ile Val Glu 
    1055                 1060                 1065             


Phe Tyr  Asn Leu Lys Ala Lys  Ile Ala Asp Ser Lys  Ile Lys Gly 
    1070                 1075                 1080             


Glu Asn  Ile Ser Glu Lys Glu  Gln Arg Asn Ile Leu  Arg Tyr Gln 
    1085                 1090                 1095             


Lys Leu  Lys Asn Lys Val Glu  Leu Arg Asp Ile Val  Glu Tyr Gly 
    1100                 1105                 1110             


Glu Ile  Ile Asn Glu Leu Ile  Gly Gln Leu Ile Asn  Trp Ser Phe 
    1115                 1120                 1125             


Met Arg  Glu Arg Asp Leu Leu  Tyr Phe Gln Leu Gly  Phe His Tyr 
    1130                 1135                 1140             


Asn Cys  Leu Arg Asn Asn Ser  Glu Lys Pro Glu Glu  Tyr Lys Lys 
    1145                 1150                 1155             


Ile Glu  Ala Asp Asp Ile Ser  Ile Asn Asp Ala Val  Leu Tyr Gln 
    1160                 1165                 1170             


Ile Ile  Gly Met Tyr Val Asn  Gly Ile Pro Val Tyr  Thr Ser Asp 
    1175                 1180                 1185             


Asn Asn  Lys Leu Lys Gly Glu  Cys Ala Asn Gly Gly  Ala Gly Gly 
    1190                 1195                 1200             


Lys Ile  Ile Ala Phe Cys Lys  Tyr Ser Glu Tyr Leu  Gly Phe Lys 
    1205                 1210                 1215             


Lys Ala  Thr Leu Tyr Glu Ala  Gly Leu Glu Val Phe  Glu Val Val 
    1220                 1225                 1230             


Ala Glu  His Asp Asp Ile Ile  Lys Leu Arg Asn Gly  Ile Glu His 
    1235                 1240                 1245             


Phe Lys  Tyr Tyr Leu Gly Asn  Tyr Arg Ser Ile Met  Ser Leu Tyr 
    1250                 1255                 1260             


Ser Glu  Val Phe Asp Arg Phe  Phe Thr Tyr Asp Leu  Lys Tyr Gln 
    1265                 1270                 1275             


Lys Asn  Val Leu Asn Leu Leu  Gln Asn Ile Leu Leu  Arg His Asn 
    1280                 1285                 1290             


Val Val  Ile Val Pro Asp Phe  Glu Ser Gly Thr Lys  Lys Val Gly 
    1295                 1300                 1305             


Asp Asn  Thr Lys Gln Ala Ala  Lys Ile Ser Ile Lys  Asn Ile Gln 
    1310                 1315                 1320             


Ser Asp  Lys Phe Thr Tyr Lys  Ile Asn Gly Gly Thr  Ala Ser Ile 
    1325                 1330                 1335             


Asp Ala  Lys Asp Asp Arg Tyr  Leu Glu Thr Ile Lys  Lys Ile Leu 
    1340                 1345                 1350             


Tyr Tyr  Pro Glu Tyr Asp Lys  Asp Ser Ser Gly Val  Cys 
    1355                 1360                 1365     


<210>  501
<211>  1289
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  501

Val Ala Val Val Ser Lys Lys Leu Lys Asn Ser Arg Ala Val Leu Tyr 
1               5                   10                  15      


Ala Thr Thr Ala Asn Lys Gly Val Ser Glu Asp Ser Glu Ser Phe Ile 
            20                  25                  30          


Val Lys Arg Ile Asp Ala Ala Asn Arg Leu Tyr Gly Val Phe Phe Arg 
        35                  40                  45              


Gly Asn Asn Lys Thr Val Pro Leu Pro Asn Gly Ile Glu Asn Lys Phe 
    50                  55                  60                  


Thr Gln Leu Leu Asn Tyr Met Glu Tyr Glu His Arg Gly Lys Ile Leu 
65                  70                  75                  80  


Ala Ala Tyr Arg Thr Gly Asp Ala Ser Gln Ile Asn Gln Cys Val Asp 
                85                  90                  95      


Asp Gln Ile Ala Trp Leu Lys Lys Ile Gln Ile Ile Lys Arg Val Lys 
            100                 105                 110         


Trp Lys Ser Lys Ala Glu Lys Tyr Tyr Val Asp Asp Lys Asp Ser Ile 
        115                 120                 125             


Lys Arg Ile Asp Phe Lys Thr Gln Lys Asp Ile Ser Glu Asp Val Leu 
    130                 135                 140                 


Asp Asp Ala Ile Lys Arg Met Arg Lys Ser Leu Lys Arg Gly Ser Asn 
145                 150                 155                 160 


Arg Trp Ile Val Lys Arg Leu Ile Arg Ala Leu Ala Gln Gly Asp Glu 
                165                 170                 175     


Thr Val Tyr Ile Thr Val Leu Glu Asp Ala Ala Phe Pro Lys Phe Val 
            180                 185                 190         


Asp Ala Val Asn Lys Asp Tyr Tyr Lys Thr Asn Leu Leu Arg Ser Leu 
        195                 200                 205             


Ala Arg His Asp Val Lys Val Gln Val His Ser Asp Tyr Ile Leu Asp 
    210                 215                 220                 


Leu Ala Ser Val Asp Asn Ala Lys Ala Asn Lys Lys Ala Leu Thr Gln 
225                 230                 235                 240 


Ile Leu Glu Lys Tyr Ala Ser Ser Glu Lys Ala Ala Thr Glu Thr Leu 
                245                 250                 255     


Leu Glu Met Lys Arg Ile Phe Phe Ala Tyr Phe Phe Ser Phe Asp Asp 
            260                 265                 270         


Glu Lys Tyr Gly Lys Phe Phe Ala Ser Glu Asn Leu Trp Lys Val Pro 
        275                 280                 285             


Ser Glu Thr Ile Gln Glu Asp Val Gly Gly Tyr Phe Asp Glu Gly Phe 
    290                 295                 300                 


Ile Pro Leu Asp Gly Tyr Ala Asp Lys Phe Asp Tyr Thr Ile Glu Asp 
305                 310                 315                 320 


Leu Thr Arg Glu Lys Pro Leu Asn Ile Gly Lys Leu Lys Ala Arg Val 
                325                 330                 335     


Arg Phe Val Asn Phe Gly Lys Tyr Leu Gln Met Met Ser Gln Asp Asn 
            340                 345                 350         


Tyr Asn Gly Asp Glu Ile Ala Gln Tyr Trp Ile Asn Tyr Ala Lys Glu 
        355                 360                 365             


Tyr Val Glu Glu Asn Tyr Gln Ala Lys Asp Tyr Lys Asn Arg Lys Val 
    370                 375                 380                 


Asp Ile Asp Ser Tyr Lys Arg Ile Arg Met Phe Lys Ala Cys Trp Lys 
385                 390                 395                 400 


Asp Ala Val Arg Phe Ile Cys Gly Lys Tyr Ile Asp Leu Gly Lys Ala 
                405                 410                 415     


Val Tyr His Phe Ala Met Pro Lys Lys Leu Ser Glu Lys Leu Glu Ser 
            420                 425                 430         


Gly Asn Glu Tyr Gly Arg Ile Arg Glu Glu Tyr Arg Asn Gly Ile Ser 
        435                 440                 445             


Ser Phe Ala Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asn 
    450                 455                 460                 


Ile Ala Asn Ala Thr Val Ala Ala Leu Ser Ala Phe Ser Arg Ser Val 
465                 470                 475                 480 


Leu Asp Tyr Ser Lys Gln Ser Glu Ala Gly Lys Glu Asp Ile Leu Phe 
                485                 490                 495     


Met Ser Lys Asp Gln Leu Lys Asn Leu Arg Lys Glu Asp Val Leu Lys 
            500                 505                 510         


Pro Ile Leu Arg Tyr Tyr Gly Gly Gln Ser Glu Val Lys Ala Phe Asp 
        515                 520                 525             


Leu Asn Gly Ile Ala Leu Met Glu Glu Ile Met Gly His Phe Ser Leu 
    530                 535                 540                 


Ile Arg Asn Glu Asn Phe His Tyr Ala Pro Gly Lys Leu Gly Glu Ile 
545                 550                 555                 560 


Lys Tyr Glu Asn Ser Leu Lys Leu Trp Gln Asn Asp Val Asp Val Tyr 
                565                 570                 575     


Ala Gln Val Val Arg Gln Lys Tyr Tyr Ser Asn Asn Thr Ala Val Phe 
            580                 585                 590         


Tyr Gly Lys Glu Asn Ile Thr Lys Leu Phe Thr Ala Leu His Gly Lys 
        595                 600                 605             


Lys Arg Val Ser Ala Ser Gln Ile Pro Ala Phe Arg Ser Ile Trp Arg 
    610                 615                 620                 


Arg Gln Glu Ile Ser Ala Phe Val Lys Val Ile Glu Lys Lys Ala Ala 
625                 630                 635                 640 


Lys Ala Lys His Glu Cys Ser Phe Leu Asn Asn Glu Glu Glu Arg Ile 
                645                 650                 655     


Lys Tyr Glu Gly Ala Leu Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Asn 
            660                 665                 670         


Asp Phe Ile Phe Leu Asp Tyr Lys Ala Arg Asp Tyr Phe Val Lys Ala 
        675                 680                 685             


Val Asn Asp Tyr Thr Gly Thr Asp Gly Ile Ala Gln Ser Thr Gln Ala 
    690                 695                 700                 


Ala Asn Asn Phe Lys Glu Tyr Val Gly Asn Leu Ala Gly Leu Asn Leu 
705                 710                 715                 720 


Thr Phe Ala Gln Ile Cys Gln Lys Ile Gln Gln Glu Tyr Asn Gln Gln 
                725                 730                 735     


Asn Thr Asn Ala Lys Lys Ser Gly Lys Thr Glu Glu Ser Tyr Ala His 
            740                 745                 750         


Phe Lys Met Leu Leu Pro Met Cys Val Lys Ser Ala Phe Gln Gln Tyr 
        755                 760                 765             


Leu Ala Asp Asn Tyr Lys Phe Leu Phe Lys Pro Glu Phe Asn Glu Ala 
    770                 775                 780                 


Leu Glu Asp Glu Gln Asp Tyr Leu Asp Glu Val Leu Val Asp Cys Gly 
785                 790                 795                 800 


Val Ala Ile Lys Gly Ile Pro Asp Asn Asp Lys Glu Lys Arg Arg Leu 
                805                 810                 815     


Ala Trp Phe Thr Phe Ala His Phe Val His Pro Lys Gln Leu Asn Leu 
            820                 825                 830         


Leu Ile Gly Asp Phe Lys Ser Tyr Ile Gln Tyr Arg Asn Asp Val Phe 
        835                 840                 845             


Lys Arg Ala Gly Phe Ala Asp Glu Tyr Gly Ser Ala Glu Glu Lys Asp 
    850                 855                 860                 


Arg Ala Glu Lys Glu Lys Asp Val Ser Ile Lys Arg Ala Lys Ser Ile 
865                 870                 875                 880 


Leu Asp Val Leu Glu Phe Val Arg Pro Ile Ala Gly Arg Val Ser Asn 
                885                 890                 895     


Val Phe Asp Asp Tyr Tyr Asp Asn Glu Asp Glu Tyr Ala Arg Tyr Leu 
            900                 905                 910         


Ser Asn Tyr Ile Thr Phe Ser Ser Lys Asn Glu Glu Pro Thr Phe Lys 
        915                 920                 925             


Asn Leu Lys Leu Phe Cys Glu Asn Thr Leu Ala Asp Gly Ala Met Val 
    930                 935                 940                 


Asp Ile Tyr Ala Asp Lys Ala Asn Pro Lys Val Leu Arg Asn Val Glu 
945                 950                 955                 960 


Ile Ala Arg Met Tyr Ala Gly Gly Asp Val Ile Leu Asn Gly Ile Glu 
                965                 970                 975     


Lys Val Asp Ala Lys Lys Val Arg Lys Tyr Tyr Glu Asn Lys Ala Ala 
            980                 985                 990         


Ala Leu Glu Leu Gln Lys Lys Gly  Leu Cys Ala Asn Glu  Glu Glu Gln 
        995                 1000                 1005             


Arg Lys  Ile Ile Lys Gln Gln  Gln Leu Lys Gly Gln  Leu Met Leu 
    1010                 1015                 1020             


Asn Asp  Val Thr Glu Thr Phe  Ser Leu Val Asn Asp  Met Leu Gly 
    1025                 1030                 1035             


Gly Leu  Val Ser Leu Ser Tyr  Leu Arg Glu Arg Asp  Lys Met Tyr 
    1040                 1045                 1050             


Leu Leu  Leu Gly Tyr Tyr Tyr  Met Ala Leu Arg Asn  Val Ser Asn 
    1055                 1060                 1065             


Trp Ser  Asn Glu Lys Leu Asp  Ser Val Val Glu Asp  Asp Ile Asn 
    1070                 1075                 1080             


Ile Lys  Ser Gly Phe Val Leu  Tyr Gln Val Val Ser  Met Phe Asp 
    1085                 1090                 1095             


Tyr Gly  Thr Ser Phe Leu Tyr  Phe Asp Ser Glu Lys  Asn Lys Trp 
    1100                 1105                 1110             


Leu Glu  Met Val Asn Ala Ser  Ile Asn Leu Lys Gly  Arg Lys Phe 
    1115                 1120                 1125             


Gly Glu  Met His Ala Ala Ser  Arg Ala Cys Ala Ile  Gln Leu Phe 
    1130                 1135                 1140             


Glu Met  Asp Glu Gln Ala Lys  Asp Lys Lys Gln Lys  Lys Pro Asp 
    1145                 1150                 1155             


Thr Gln  Asp Lys Lys Asp Lys  Glu Met Ser Val Arg  Glu Leu Arg 
    1160                 1165                 1170             


Asn Tyr  Val Asp His Phe Lys  Tyr Tyr Val Lys Phe  Asp Lys Ser 
    1175                 1180                 1185             


Ile Val  Glu Leu Tyr Ala Glu  Phe Tyr Thr Lys Phe  Phe Val Tyr 
    1190                 1195                 1200             


Ser Thr  Lys Leu Arg Lys Ser  Val Ile Val Asn Phe  Ser Asn Ile 
    1205                 1210                 1215             


Leu Glu  Arg Tyr Phe Leu Glu  Asn Ser Asn Ser Phe  Thr Val Leu 
    1220                 1225                 1230             


Glu Asp  Asn Lys Thr Glu Ile  Asn Leu Leu Ser Thr  Leu Lys Ser 
    1235                 1240                 1245             


Gln Gln  Phe Thr Tyr Lys Leu  Asn Ala Lys Asp Asn  Lys Gly Lys 
    1250                 1255                 1260             


Gln Leu  Thr Cys Asn Leu Asn  Ala Lys Ser Ala Asn  Phe Val Lys 
    1265                 1270                 1275             


Ser Val  Lys Glu Val Leu Lys  Tyr Lys Lys Cys 
    1280                 1285                 


<210>  502
<211>  1289
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  502

Val Ala Val Val Ser Lys Lys Leu Lys Asn Ser Arg Ala Val Leu Tyr 
1               5                   10                  15      


Ala Thr Thr Ala Asn Lys Gly Val Ser Glu Asp Ser Glu Ser Phe Ile 
            20                  25                  30          


Val Lys Arg Ile Asp Ala Ala Asn Arg Leu Tyr Gly Val Phe Phe Arg 
        35                  40                  45              


Gly Asn Asn Lys Thr Val Pro Leu Pro Asn Gly Ile Glu Asn Lys Phe 
    50                  55                  60                  


Thr Gln Leu Leu Asn Tyr Met Glu Tyr Glu His Arg Gly Lys Ile Leu 
65                  70                  75                  80  


Ala Ala Tyr Arg Thr Gly Asp Ala Ser Gln Ile Asn Gln Cys Val Asp 
                85                  90                  95      


Asp Gln Ile Ala Trp Leu Lys Lys Ile Gln Ile Ile Lys Arg Val Lys 
            100                 105                 110         


Trp Lys Ser Lys Ala Glu Lys Tyr Tyr Val Asp Asp Lys Asp Ser Ile 
        115                 120                 125             


Lys Arg Ile Asp Phe Lys Thr Gln Lys Asp Ile Ser Glu Asp Val Leu 
    130                 135                 140                 


Asp Asp Ala Ile Lys Arg Met Arg Lys Ser Leu Lys Arg Gly Ser Asn 
145                 150                 155                 160 


Arg Trp Ile Val Lys Arg Leu Ile Arg Ala Leu Ala Gln Gly Asp Glu 
                165                 170                 175     


Thr Val Tyr Ile Thr Val Leu Glu Asp Ala Ala Phe Pro Lys Phe Val 
            180                 185                 190         


Asp Ala Val Asn Lys Asp Tyr Tyr Lys Thr Asn Leu Leu Arg Ser Leu 
        195                 200                 205             


Ala Arg His Asp Val Lys Val Gln Val His Ser Asp Tyr Ile Leu Asp 
    210                 215                 220                 


Leu Ala Ser Val Asp Asn Ala Lys Ala Asn Lys Lys Ala Leu Thr Gln 
225                 230                 235                 240 


Ile Leu Glu Lys Tyr Ala Ser Ser Glu Lys Ala Ala Thr Glu Thr Leu 
                245                 250                 255     


Leu Glu Met Lys Arg Ile Phe Phe Ala Tyr Phe Phe Ser Phe Asp Asp 
            260                 265                 270         


Glu Lys Tyr Gly Lys Phe Phe Ala Ser Glu Asn Leu Trp Lys Val Pro 
        275                 280                 285             


Ser Glu Thr Ile Gln Glu Asp Val Gly Gly Tyr Phe Asp Glu Gly Phe 
    290                 295                 300                 


Ile Pro Leu Asp Gly Tyr Ala Asp Lys Phe Asp Tyr Thr Ile Glu Asp 
305                 310                 315                 320 


Leu Thr Arg Glu Lys Pro Leu Asn Ile Gly Lys Leu Lys Ala Arg Val 
                325                 330                 335     


Arg Phe Val Asn Phe Gly Lys Tyr Leu Gln Met Met Ser Gln Asp Asn 
            340                 345                 350         


Tyr Asn Gly Asp Glu Ile Ala Gln Tyr Trp Ile Asn Tyr Ala Lys Glu 
        355                 360                 365             


Tyr Val Glu Glu Asn Tyr Gln Ala Lys Asp Tyr Lys Asn Arg Lys Val 
    370                 375                 380                 


Asp Ile Asp Ser Tyr Lys Arg Ile Arg Met Phe Lys Ala Cys Trp Lys 
385                 390                 395                 400 


Asp Ala Val Arg Phe Ile Cys Gly Lys Tyr Ile Asp Leu Gly Lys Ala 
                405                 410                 415     


Val Tyr His Phe Ala Met Pro Lys Lys Leu Ser Glu Lys Leu Glu Ser 
            420                 425                 430         


Gly Asn Glu Tyr Gly Arg Ile Arg Glu Glu Tyr Arg Asn Gly Ile Ser 
        435                 440                 445             


Ser Phe Ala Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asn 
    450                 455                 460                 


Ile Ala Asn Ala Thr Val Ala Ala Leu Ser Ala Phe Ser Arg Ser Val 
465                 470                 475                 480 


Leu Asp Tyr Ser Lys Gln Ser Glu Ala Gly Lys Glu Asp Ile Leu Phe 
                485                 490                 495     


Met Ser Lys Asp Gln Leu Lys Asn Leu Arg Lys Glu Asp Val Leu Lys 
            500                 505                 510         


Pro Ile Leu Arg Tyr Tyr Gly Gly Gln Ser Glu Val Lys Ala Phe Asp 
        515                 520                 525             


Leu Asn Gly Ile Ala Leu Met Glu Glu Ile Met Gly His Phe Ser Leu 
    530                 535                 540                 


Ile Arg Asn Glu Asn Phe His Tyr Ala Pro Gly Lys Leu Gly Glu Ile 
545                 550                 555                 560 


Lys Tyr Glu Asn Ser Leu Lys Leu Trp Gln Asn Asp Val Asp Val Tyr 
                565                 570                 575     


Ala Gln Val Val Arg Gln Lys Tyr Tyr Ser Asn Asn Thr Ala Val Phe 
            580                 585                 590         


Tyr Gly Lys Glu Asn Ile Thr Lys Leu Phe Thr Ala Leu His Gly Lys 
        595                 600                 605             


Lys Arg Val Ser Ala Ser Gln Ile Pro Ala Phe Arg Ser Ile Trp Arg 
    610                 615                 620                 


Arg Gln Glu Ile Ser Ala Phe Val Lys Val Ile Glu Lys Lys Ala Ala 
625                 630                 635                 640 


Lys Ala Lys His Glu Cys Ser Phe Leu Asn Asn Glu Glu Glu Arg Ile 
                645                 650                 655     


Lys Tyr Glu Gly Ala Leu Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Asn 
            660                 665                 670         


Asp Phe Ile Phe Leu Asp Tyr Lys Ala Arg Asp Tyr Phe Val Lys Ala 
        675                 680                 685             


Val Asn Asp Tyr Thr Gly Thr Asp Gly Ile Ala Gln Ser Thr Gln Ala 
    690                 695                 700                 


Ala Asn Asn Phe Lys Glu Tyr Val Gly Asn Leu Ala Gly Leu Asn Leu 
705                 710                 715                 720 


Thr Phe Ala Gln Ile Cys Gln Lys Ile Gln Gln Glu Tyr Asn Gln Gln 
                725                 730                 735     


Asn Thr Asn Ala Lys Lys Ser Gly Lys Thr Glu Glu Ser Tyr Ala His 
            740                 745                 750         


Phe Lys Met Leu Leu Pro Met Cys Val Lys Ser Ala Phe Gln Gln Tyr 
        755                 760                 765             


Leu Ala Asp Asn Tyr Lys Phe Leu Phe Lys Pro Glu Phe Asn Glu Ala 
    770                 775                 780                 


Leu Glu Asp Glu Gln Asp Tyr Leu Asp Glu Val Leu Val Asp Cys Gly 
785                 790                 795                 800 


Val Ala Ile Lys Gly Ile Pro Asp Asn Asp Lys Glu Lys Arg Arg Leu 
                805                 810                 815     


Ala Trp Phe Thr Phe Ala His Phe Val His Pro Lys Gln Leu Asn Leu 
            820                 825                 830         


Leu Ile Gly Asp Phe Lys Ser Tyr Ile Gln Tyr Arg Asn Asp Val Phe 
        835                 840                 845             


Lys Arg Ala Gly Phe Ala Asp Glu Tyr Gly Ser Ala Glu Glu Lys Asp 
    850                 855                 860                 


Arg Ala Glu Lys Glu Lys Asp Val Ser Ile Lys Arg Ala Lys Ser Ile 
865                 870                 875                 880 


Leu Asp Val Leu Glu Phe Val Arg Pro Ile Ala Gly Arg Val Ser Asn 
                885                 890                 895     


Val Phe Asp Asp Tyr Tyr Asp Asn Glu Asp Glu Tyr Ala Arg Tyr Leu 
            900                 905                 910         


Ser Asn Tyr Ile Thr Phe Ser Ser Lys Asn Glu Glu Pro Thr Phe Lys 
        915                 920                 925             


Asn Leu Lys Leu Phe Cys Glu Asn Thr Leu Ala Asp Gly Ala Met Val 
    930                 935                 940                 


Asp Ile Tyr Ala Asp Lys Ala Asn Pro Lys Val Leu Arg Asn Val Glu 
945                 950                 955                 960 


Ile Ala Arg Met Tyr Ala Gly Gly Asp Val Ile Leu Asn Gly Ile Glu 
                965                 970                 975     


Lys Val Asp Ala Lys Lys Val Arg Lys Tyr Tyr Glu Asn Lys Ala Ala 
            980                 985                 990         


Ala Leu Glu Leu Gln Lys Lys Gly  Leu Cys Ala Asn Glu  Glu Glu Gln 
        995                 1000                 1005             


Arg Lys  Ile Ile Lys Gln Gln  Gln Leu Lys Gly Gln  Leu Met Leu 
    1010                 1015                 1020             


Asn Asp  Val Thr Glu Thr Phe  Ser Leu Val Asn Asp  Met Leu Gly 
    1025                 1030                 1035             


Gly Leu  Val Ser Leu Ser Tyr  Leu Arg Glu Arg Asp  Lys Met Tyr 
    1040                 1045                 1050             


Leu Leu  Leu Gly Tyr Tyr Tyr  Met Ala Leu Arg Asn  Val Ser Asn 
    1055                 1060                 1065             


Trp Ser  Asn Glu Lys Leu Asp  Ser Val Val Glu Asp  Asp Ile Asn 
    1070                 1075                 1080             


Ile Lys  Ser Gly Phe Val Leu  Tyr Gln Val Val Ser  Met Phe Asp 
    1085                 1090                 1095             


Tyr Gly  Thr Ser Phe Leu Tyr  Phe Asp Ser Glu Lys  Asn Lys Trp 
    1100                 1105                 1110             


Leu Glu  Met Val Asn Ala Ser  Ile Asn Leu Lys Gly  Arg Lys Phe 
    1115                 1120                 1125             


Gly Glu  Met His Ala Ala Ser  Arg Ala Cys Ala Ile  Gln Leu Phe 
    1130                 1135                 1140             


Glu Met  Asp Glu Gln Ala Lys  Asp Lys Lys Gln Lys  Lys Pro Asp 
    1145                 1150                 1155             


Thr Gln  Asp Lys Lys Asp Lys  Glu Met Ser Val Arg  Glu Leu Arg 
    1160                 1165                 1170             


Asn Tyr  Val Asp His Phe Lys  Tyr Tyr Val Lys Phe  Asp Lys Ser 
    1175                 1180                 1185             


Ile Val  Glu Leu Tyr Ala Glu  Phe Tyr Thr Lys Phe  Phe Val Tyr 
    1190                 1195                 1200             


Ser Thr  Lys Leu Arg Lys Ser  Val Ile Val Asn Phe  Ser Asn Ile 
    1205                 1210                 1215             


Leu Glu  Arg Tyr Phe Leu Glu  Asn Ser Asn Ser Phe  Thr Val Leu 
    1220                 1225                 1230             


Glu Asp  Asn Lys Thr Glu Ile  Asn Leu Leu Ser Thr  Leu Lys Ser 
    1235                 1240                 1245             


Gln Gln  Phe Thr Tyr Lys Leu  Asn Ala Lys Asp Asn  Lys Gly Lys 
    1250                 1255                 1260             


Gln Leu  Thr Cys Asn Leu Asn  Ala Lys Ser Ala Asn  Phe Val Lys 
    1265                 1270                 1275             


Ser Val  Lys Glu Val Leu Lys  Tyr Lys Lys Cys 
    1280                 1285                 


<210>  503
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  503

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Pro Gly Thr Asp Thr 
            20                  25                  30          


Ile Asp Leu Lys Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Asp Lys Pro Lys Lys 
    50                  55                  60                  


Trp Lys Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Glu Tyr Val Lys Asn Ser Gln Glu Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Asp Ser Gln Gly Thr Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Gly Phe Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys His 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ser Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ser Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Phe 
            660                 665                 670         


Val Arg Lys Asn Phe Pro Glu Asp Ile Thr Asn Val Phe Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Lys Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Tyr 
                805                 810                 815     


Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Gly Trp Thr Ser Thr 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Leu Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Arg Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Gly  Asp Ile Glu Glu Phe  Tyr Asp Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Asp Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Met  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Glu Tyr Glu Lys Ile  Glu Ile Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Gly Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Val  Tyr Ala Pro Glu Lys  Gly Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Ile Gly  Val Lys Val 
    1145                 1150                 1155             


Asp Ala  Phe Lys Arg Tyr Ser  Glu His Leu Gly Leu  His Lys Glu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Ile  Ile Glu Glu 
    1175                 1180                 1185             


His Glu  Asp Val Ile Asn Leu  Arg Asn Ser Ile Asn  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Lys Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Met Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Tyr Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Phe Glu Ser  Gly Val Lys Thr Ile  Gly Asp Gln 
    1250                 1255                 1260             


Thr Lys  Pro Cys Ala Lys Leu  Ser Ile Lys Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Glu Tyr Lys Val Lys  Gly Gly Thr Leu Val  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Asp  Asp Glu Asp Ser Asn  Ala Lys Lys Pro Ala  Ile Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Gly Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Pro Asn 
    1370                 1375                 1380         


<210>  504
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  504

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Pro Gly Thr Asp Thr 
            20                  25                  30          


Ile Asp Leu Lys Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Lys Val Phe Asn Gln Ile Gln Val Gly Asn Lys Pro Lys Lys 
    50                  55                  60                  


Trp Lys Lys Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Glu Tyr Val Glu Ser Ser Gln Arg Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Asp Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Glu Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Gly Leu Phe Val Asn Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Ile Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Ser Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Tyr Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Lys Asp Arg Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Lys Glu Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Gln Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Phe 
            660                 665                 670         


Ile Arg Lys Asn Phe Pro Glu Asp Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Lys Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Tyr 
                805                 810                 815     


Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Thr 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Asp Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Asp Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asn  Ser Glu Lys Lys Glu  Ala Tyr Gln Lys Ile  Glu Val Asn 
    1100                 1105                 1110             


Gly Asp  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Val  Tyr Ala Pro Asp Glu  Lys Gly Asp 
    1130                 1135                 1140             


Ile Leu  Lys Glu Gln Cys Thr  Lys Gly Gly Ala Gly  Gly Lys Ile 
    1145                 1150                 1155             


Ser Ala  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Lys Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Lys Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Lys Gln 
    1250                 1255                 1260             


Thr Thr  Ser Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Ser Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Lys  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Val Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Gly Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Pro Asn 
    1370                 1375                 1380         


<210>  505
<211>  1235
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  505

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Leu Ser Leu Ile His  Ile Ser Glu 
    1220                 1225                 1230             


Pro Thr  
    1235 


<210>  506
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  506

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Leu Tyr Gln Ile Val  Ser Ala Phe Asn Phe  Gly Ser Lys 
    1205                 1210                 1215             


Leu Leu  Tyr Ile Ser Glu Asp  Gly Arg Trp Lys Met  Ala Gly Gly 
    1220                 1225                 1230             


Ala Phe  Pro Gly Lys Tyr Gly  Arg Phe Glu Asn Asp  Tyr Asn His 
    1235                 1240                 1245             


Arg Thr  Ser Leu Ser Lys Val  Ile Arg Leu Phe Glu  Asn Glu Ser 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ile Ile Tyr  Trp Arg Asp Tyr Val  Asp His Met 
    1265                 1270                 1275             


Lys Tyr  Tyr Val Asn Gln Asn  Gln Ser Ile Met Glu  Ile Tyr Ser 
    1280                 1285                 1290             


Ala Phe  Tyr Ser Lys Val Leu  Gly Tyr Ser Ala Lys  Leu Arg Lys 
    1295                 1300                 1305             


Ser Val  Val Phe Asn Leu Gln  Ala Ala Leu Glu Lys  His His Ile 
    1310                 1315                 1320             


Asn Pro  Glu Cys Ile Trp Met  Thr Ser Asp Gly Lys  Cys Ala Asp 
    1325                 1330                 1335             


Ile Lys  Leu Met Lys Asn Leu  Glu Ser Gln Lys Phe  Thr Tyr Lys 
    1340                 1345                 1350             


Leu Ala  Lys Arg Glu Gly Glu  Lys Thr Glu Arg Lys  Ile Cys Met 
    1355                 1360                 1365             


Asn Ala  Leu Asn Glu Asn Phe  Leu Lys Thr Ile Arg  Thr Ser Leu 
    1370                 1375                 1380             


Glu Tyr  Lys Lys 
    1385         


<210>  507
<211>  1159
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  507

Met Lys Val Thr Lys Val Gly Gly Ile Ser His Lys Lys Tyr Thr Ser 
1               5                   10                  15      


Glu Gly Arg Leu Val Lys Ser Glu Ser Glu Glu Asn Arg Thr Asp Glu 
            20                  25                  30          


Arg Leu Ser Ala Leu Leu Asn Met Arg Leu Asp Met Tyr Ile Lys Asn 
        35                  40                  45              


Pro Ser Ser Thr Glu Thr Lys Glu Asn Gln Lys Arg Ile Gly Lys Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Met Val Tyr Leu Lys Asp Asn Thr Leu 
65                  70                  75                  80  


Ser Leu Lys Asn Gly Lys Lys Glu Asn Ile Asp Arg Glu Tyr Ser Glu 
                85                  90                  95      


Thr Asp Ile Leu Glu Ser Asp Val Arg Asp Lys Lys Asn Phe Ala Val 
            100                 105                 110         


Leu Lys Lys Ile Tyr Leu Asn Glu Asn Val Asn Ser Glu Glu Leu Glu 
        115                 120                 125             


Val Phe Arg Asn Asp Ile Lys Lys Lys Leu Asn Lys Ile Asn Ser Leu 
    130                 135                 140                 


Lys Tyr Ser Phe Glu Lys Asn Lys Ala Asn Tyr Gln Lys Ile Asn Glu 
145                 150                 155                 160 


Asn Asn Ile Glu Lys Val Glu Gly Lys Ser Lys Arg Asn Ile Ile Tyr 
                165                 170                 175     


Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asp Ala Tyr Val Ser Asn Val 
            180                 185                 190         


Lys Glu Ala Phe Asp Lys Leu Tyr Lys Glu Glu Asp Ile Ala Lys Leu 
        195                 200                 205             


Val Leu Glu Ile Glu Asn Leu Thr Lys Leu Glu Lys Tyr Lys Ile Arg 
    210                 215                 220                 


Glu Phe Tyr His Glu Ile Ile Gly Arg Lys Asn Asp Lys Glu Asn Phe 
225                 230                 235                 240 


Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Met Lys Glu 
                245                 250                 255     


Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser Gln Val 
            260                 265                 270         


Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys Asn Ile 
        275                 280                 285             


Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln Leu Leu 
    290                 295                 300                 


Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp Lys Ile 
305                 310                 315                 320 


Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu Asn Lys 
                325                 330                 335     


Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys Tyr Asn 
            340                 345                 350         


Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile Ala Arg 
        355                 360                 365             


Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val Ser Ser 
    370                 375                 380                 


Val Ser Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn Glu Asn 
385                 390                 395                 400 


Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn Lys Gly 
                405                 410                 415     


Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Leu Tyr Asp Asn Asn 
            420                 425                 430         


Arg Gln Asn Glu Val Lys Lys Asn Leu Lys Met Phe Tyr Ser Tyr Asp 
        435                 440                 445             


Phe Asn Met Asp Ser Lys Asn Glu Ile Glu Asp Phe Phe Ser Asn Ile 
    450                 455                 460                 


Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe Asn Leu 
465                 470                 475                 480 


Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala Pro Ser 
                485                 490                 495     


Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys Lys Leu 
            500                 505                 510         


Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe Arg Tyr 
        515                 520                 525             


Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg Phe Glu 
    530                 535                 540                 


Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys Leu Tyr 
545                 550                 555                 560 


Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp Lys Thr 
                565                 570                 575     


Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp Ala Gln 
            580                 585                 590         


Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn Tyr Phe 
        595                 600                 605             


Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile Ile Glu 
    610                 615                 620                 


Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr Lys Leu 
625                 630                 635                 640 


Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr Leu Ala 
                645                 650                 655     


Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp Glu Glu 
            660                 665                 670         


Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu Lys Gly 
        675                 680                 685             


Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile Tyr Ile 
    690                 695                 700                 


Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys Gln Glu 
705                 710                 715                 720 


Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile Lys Ile 
                725                 730                 735     


Pro Tyr Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly Asn Ile 
            740                 745                 750         


Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu Lys Leu 
        755                 760                 765             


Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu Lys Tyr 
    770                 775                 780                 


Gln Ser Ala Asn Lys Glu Glu Ala Phe Ser Asp Gln Leu Glu Leu Ile 
785                 790                 795                 800 


Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe Glu Leu 
                805                 810                 815     


Glu Val Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn Lys Ile 
            820                 825                 830         


Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile Tyr Phe 
        835                 840                 845             


Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile Lys Lys 
    850                 855                 860                 


Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala Lys Tyr 
865                 870                 875                 880 


Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys Asn Glu 
                885                 890                 895     


Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys Tyr Ala 
            900                 905                 910         


Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Lys Lys Tyr 
        915                 920                 925             


Glu Lys Ala Ile Arg Asn Ile Gln Gln Tyr Thr His Leu Lys Asn Lys 
    930                 935                 940                 


Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Ser Leu Leu Leu Arg Ile 
945                 950                 955                 960 


Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp Leu Arg 
                965                 970                 975     


Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu Glu Ile 
            980                 985                 990         


Phe Asn Phe Asp Asn Ser Lys Asn  Val Lys Tyr Lys Asn  Gly Gln Ile 
        995                 1000                 1005             


Val Glu  Lys Tyr Ile Asn Phe  Tyr Lys Glu Leu Tyr  Lys Asp Asp 
    1010                 1015                 1020             


Thr Glu  Lys Ile Ser Ile Tyr  Ser Asp Lys Lys Val  Lys Glu Leu 
    1025                 1030                 1035             


Lys Lys  Glu Lys Lys Asp Leu  Tyr Ile Arg Asn Tyr  Ile Ala His 
    1040                 1045                 1050             


Phe Asn  Tyr Ile Pro Asn Ala  Glu Ile Ser Leu Leu  Glu Val Leu 
    1055                 1060                 1065             


Glu Asn  Leu Arg Lys Leu Leu  Ser Tyr Asp Arg Lys  Leu Lys Asn 
    1070                 1075                 1080             


Ala Ile  Met Lys Ser Ile Val  Asp Ile Leu Lys Glu  Tyr Gly Phe 
    1085                 1090                 1095             


Val Ala  Lys Phe Lys Ile Gly  Ala Asp Lys Lys Ile  Gly Ile Gln 
    1100                 1105                 1110             


Thr Leu  Glu Ser Glu Lys Ile  Val His Leu Lys Asn  Leu Lys Lys 
    1115                 1120                 1125             


Lys Lys  Leu Met Thr Asp Arg  Asn Ser Glu Glu Leu  Cys Glu Leu 
    1130                 1135                 1140             


Val Lys  Val Met Phe Glu Tyr  Lys Met Lys Glu Lys  Lys Ser Glu 
    1145                 1150                 1155             


Asn 
    


<210>  508
<211>  1390
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  508

Met Gly Asn Leu Phe Gly His Lys Arg Trp Tyr Glu Val Ser Asp Arg 
1               5                   10                  15      


Gly Asp Asn Lys Ile Lys Arg Lys Val Lys Val Lys Arg Asn Tyr Asp 
            20                  25                  30          


Gly Asn Lys Tyr Ile Leu Asn Ile Asn Glu Asn Asn Asn Lys Glu Lys 
        35                  40                  45              


Ile Asp Asn Asn Lys Phe Ile Arg Glu Phe Val Asn Tyr Lys Lys Asn 
    50                  55                  60                  


Asp Asn Val Leu Ile Glu Phe Lys Arg Lys Phe His Ala Gly Asn Ile 
65                  70                  75                  80  


Leu Phe Lys Leu Lys Gly Asn Lys Arg Ser Ile Glu Asp Thr Asn Gly 
                85                  90                  95      


Phe Leu Lys Thr Glu Glu Ile Ile Leu Asp Lys Glu Val Tyr Gly Gln 
            100                 105                 110         


Ser Glu Lys Leu Arg Asn Glu Lys Gly Ile Thr Lys Gln Asp Ile Leu 
        115                 120                 125             


Lys Glu Ile Ile Asp Lys Gly Ile Asp Lys Ser Asn Asp Lys Ile Leu 
    130                 135                 140                 


Val Lys Thr Lys Phe Gly Lys Glu Ile Thr Ile Asn Phe Thr Asp Glu 
145                 150                 155                 160 


Asp Lys Lys Asn Lys Asn Glu Tyr Gln Ile Thr Leu Lys Ile Leu Pro 
                165                 170                 175     


Glu Asn Glu Leu Lys Ile Lys Arg Glu Val Tyr Asn Ile Phe Lys Ile 
            180                 185                 190         


Ile Asn Met Asn Leu Tyr Gln Ile Ile Lys Gly Ile Ile Glu Asn Lys 
        195                 200                 205             


Glu Ile Phe Lys Asn Arg Tyr Tyr Asp Glu Ile Leu Lys Glu Lys Leu 
    210                 215                 220                 


Ser Lys Asn Asn Gln Ile Ile Asn Thr Leu Thr Asn Leu Asn Lys Ile 
225                 230                 235                 240 


Arg Lys Glu Ile Arg Asp Asn Arg Asp Asn Ile Ile Ser Phe Val Lys 
                245                 250                 255     


Phe Tyr Phe Asn Val Gly Gly Asp Lys Lys Lys Ser Glu Asn Lys Lys 
            260                 265                 270         


Met Phe Val Glu Lys Ile Leu Asn Ile Asn Val Asp Leu Thr Val Glu 
        275                 280                 285             


Asp Ile Val Asp Phe Ile Val Lys Glu Leu Lys Phe Trp Asn Ile Thr 
    290                 295                 300                 


Lys Arg Ile Glu Lys Val Lys Glu Phe Asn Asn Lys Ser Leu Glu Asn 
305                 310                 315                 320 


Arg Arg Asn Arg Thr Tyr Ile Lys Ser Tyr Val Leu Leu Asp Lys His 
                325                 330                 335     


Glu Lys Phe Lys Arg Asp Arg Glu Asn Lys Lys Asp Lys Ile Val Lys 
            340                 345                 350         


Leu Phe Val Lys Asp Ile His Asn Asp Lys Met Glu Glu Lys Ile Asn 
        355                 360                 365             


His Ile Leu Ser Glu Phe Lys Ile Lys Glu Leu Ile Glu Lys Leu Lys 
    370                 375                 380                 


Glu Asn Thr Glu Asn Lys Asn Phe Asp Thr Glu Ile Phe Gly Ile Phe 
385                 390                 395                 400 


Lys Lys His Tyr Lys Val Asn Phe Asp Ser Lys Lys Phe Ser Asn Lys 
                405                 410                 415     


Ser Asp Glu Glu Lys Glu Leu Tyr Lys Ile Ile Tyr Arg Tyr Leu Lys 
            420                 425                 430         


Gly Arg Ile Glu Lys Ile Leu Ile Asn Glu Gln Lys Val Arg Leu Lys 
        435                 440                 445             


Lys Met Glu Lys Ile Glu Ile Glu Lys Ile Leu Asp Glu Ser Val Leu 
    450                 455                 460                 


Ser Glu Lys Ile Leu Lys Arg Val Lys Gln Tyr Thr Leu Glu His Ile 
465                 470                 475                 480 


Met Tyr Leu Gly Lys Leu Ile His Asn Lys Ile Asn Met Ala Thr Val 
                485                 490                 495     


Asn Thr Asn Asp Phe Phe Arg Leu His Ala Lys Glu Glu Leu Asp Leu 
            500                 505                 510         


Glu Leu Ile Thr Phe Phe Ala Ser Thr Asn Met Glu Leu Asn Lys Ile 
        515                 520                 525             


Phe Ser Arg Glu Asn Ile Asn Asn Asp Glu Asn Ile Asp Phe Phe Gly 
    530                 535                 540                 


Gly Asp Arg Glu Lys Asn Tyr Val Leu Asp Lys Lys Asn Leu Asn Ser 
545                 550                 555                 560 


Lys Ile Lys Ile Ile Arg Asp Leu Asp Phe Ile Asp Asn Lys Asn Asn 
                565                 570                 575     


Ile Thr Asn Asn Phe Ile Ser Lys Phe Thr Lys Ile Gly Thr Asn Glu 
            580                 585                 590         


Arg Asn Arg Ile Leu His Ala Ser Ser Lys Glu Arg Asp Leu Gln Gly 
        595                 600                 605             


Thr Gln Asp Asp Tyr Asn Lys Val Ile Asn Ile Ile Gln Asn Leu Lys 
    610                 615                 620                 


Ile Ser Asp Glu Glu Val Ser Lys Ala Leu Asn Leu Asp Val Val Phe 
625                 630                 635                 640 


Lys Asp Lys Lys Asn Ile Ile Thr Lys Ile Asn Asp Ile Glu Ile Ser 
                645                 650                 655     


Glu Glu Asn Asn Ser Val Ile Lys Tyr Leu Pro Ser Phe Ser Lys Val 
            660                 665                 670         


Leu Pro Glu Ile Leu Asn Leu Tyr Lys Asn Lys Asn Lys Asn Asn Pro 
        675                 680                 685             


Phe Asp Thr Thr Glu Thr Glu Arg Ile Met Leu Asn Ala Leu Ile Tyr 
    690                 695                 700                 


Val Asn Lys Glu Leu Tyr Lys Lys Leu Ile Leu Glu Lys Asn Leu Glu 
705                 710                 715                 720 


Glu Asn Glu Ser Lys Asn Lys Phe Leu Lys Glu Leu Lys Lys Asn Leu 
                725                 730                 735     


Gly Gly Thr Asp Glu Ile Asp Glu Asn Ile Ile Glu Ser Tyr Tyr Lys 
            740                 745                 750         


Asn Thr Gln Ile Ser Ala Ser Lys Gly Asn Asn Lys Ala Ile Lys Lys 
        755                 760                 765             


Tyr Gln Lys Lys Ile Ile Glu Cys Tyr Ile Lys Tyr Leu Glu Glu Asn 
    770                 775                 780                 


Tyr Arg Glu Leu Phe Asp Phe Ser Asp Phe Lys Met Asn Ile Gln Glu 
785                 790                 795                 800 


Ile Lys Lys Gln Ile Lys Glu Ile Asn Asp Asn Lys Thr Tyr Lys Arg 
                805                 810                 815     


Ile Thr Ile Lys Thr Ser Asp Lys Ser Ile Val Ile Asn Asp Asp Phe 
            820                 825                 830         


Glu Tyr Ile Ile Ser Ile Phe Ala Leu Leu Asn Ser Asn Thr Tyr Ile 
        835                 840                 845             


Asn Lys Ile Arg Asn Arg Phe Phe Ala Thr Ser Val Trp Leu Asn Thr 
    850                 855                 860                 


Gln Lys Tyr Glu Asn Ile Ile Asp Ile Leu Asp Lys Ile Leu Ser Ile 
865                 870                 875                 880 


Asn Leu Leu Arg Glu Asn Asn Ile Ala Asp Ile Leu Asp Leu Lys Asn 
                885                 890                 895     


Thr Ile Ile Glu Ala Lys Ile Val Glu Asn Asn Glu Glu Cys Ile Lys 
            900                 905                 910         


Asn Tyr Ile Phe Glu Asn Asn Glu Glu Glu Leu Lys Lys Arg Leu Phe 
        915                 920                 925             


Cys Glu Glu Leu Val Asn Lys Glu Asp Val Leu Lys Ile Phe Glu Asp 
    930                 935                 940                 


Lys Asn Phe Lys Phe Lys Asn Phe Ile Lys Lys Thr Gly Asn Glu Asn 
945                 950                 955                 960 


Phe Thr Ile Asp Phe Asp Ile Leu Phe Asn Leu Glu Cys Asn Ser Glu 
                965                 970                 975     


Leu Asn Ala Lys Lys Val Ile Gly Gln Asn Ser Gln Arg Leu Asn Leu 
            980                 985                 990         


Phe Ile Lys Asn Thr Ile Asp Glu  Tyr Lys Ser Lys Ile  Lys Thr Ser 
        995                 1000                 1005             


Phe Ser  Ser Glu Phe Leu Glu  Lys Tyr Lys Lys Glu  Ile Asp Asn 
    1010                 1015                 1020             


Leu Val  Glu Ser Thr Glu Ser  Glu Asn Lys Asn Lys  Phe Glu Lys 
    1025                 1030                 1035             


Ile Tyr  Tyr Pro Glu Glu His  Lys Asn Glu Leu Tyr  Ile Tyr Lys 
    1040                 1045                 1050             


Lys Asn  Leu Phe Leu Asn Ile  Gly Asn Pro Asn Phe  Asp Lys Ile 
    1055                 1060                 1065             


Tyr Glu  Leu Ile Ser Lys Asp  Ile Lys Asn Ala Asn  Thr Glu Ile 
    1070                 1075                 1080             


Leu Phe  Asn Asp Asp Ile Arg  Lys Asn Lys Ile Ala  Glu Ile Asp 
    1085                 1090                 1095             


Val Ile  Leu Lys Lys Leu Asn  Asp Lys Leu Asn Gly  Tyr Ser Lys 
    1100                 1105                 1110             


Glu Tyr  Lys Glu Lys Tyr Ile  Lys Lys Leu Lys Glu  Asn Gln Glu 
    1115                 1120                 1125             


Asn Asn  Asp Phe Phe Ala Lys  Asn Ile Gln Asn Glu  Asn Tyr Asn 
    1130                 1135                 1140             


Ser Phe  Glu Glu Phe Lys Glu  Asp Tyr Asn Lys Val  Ser Glu Tyr 
    1145                 1150                 1155             


Lys Lys  Ile Arg Asp Leu Val  Glu Phe Asn Tyr Leu  Asn Lys Ile 
    1160                 1165                 1170             


Glu Ser  Tyr Leu Ile Asp Ile  Asn Trp Lys Leu Ala  Ile Gln Met 
    1175                 1180                 1185             


Ala Arg  Phe Glu Arg Asp Met  His Tyr Ile Val Asn  Gly Leu Asp 
    1190                 1195                 1200             


Tyr Leu  Tyr Ile Ile Arg Leu  Glu Lys Asp Arg Asn  Gln Asp Arg 
    1205                 1210                 1215             


Ser Ser  Pro Tyr Pro Lys Tyr  Lys Asn Gly Val Leu  Asp Tyr Thr 
    1220                 1225                 1230             


Lys Ser  Tyr Tyr Asn Phe Lys  Asp Tyr Gln Glu Phe  Met Asp Ile 
    1235                 1240                 1245             


Cys Ser  Lys Phe Gly Ile Asp  Leu Ser Glu Asn Ser  Glu Ile Asn 
    1250                 1255                 1260             


Lys Pro  Glu Asn Glu Ser Ile  Arg Asn Tyr Ile Ser  His Phe Tyr 
    1265                 1270                 1275             


Ile Val  Arg Asn Pro Phe Val  Asp Tyr Ser Ile Ala  Glu Gln Ile 
    1280                 1285                 1290             


Asp Arg  Val Ser Asn Leu Leu  Ser Tyr Ser Thr Arg  Tyr Asn Asn 
    1295                 1300                 1305             


Ser Thr  Tyr Ala Ser Val Phe  Glu Val Phe Lys Lys  Asp Val Asp 
    1310                 1315                 1320             


Leu Asp  Tyr Asp Lys Leu Lys  Thr Lys Phe Lys Leu  Phe Asp Asp 
    1325                 1330                 1335             


Glu Lys  Asn Asp Asp Ile Lys  Ile Leu Glu Ile Lys  Asn Leu Ile 
    1340                 1345                 1350             


Glu Ser  Lys Lys Val Ser Val  Leu Glu Leu Glu Ser  Tyr Asn Ser 
    1355                 1360                 1365             


Asp Tyr  Ile Lys Asn Leu Ile  Ile Glu Leu Leu Thr  Lys Val Glu 
    1370                 1375                 1380             


Asn Lys  Asp Glu Ile Ser Ser  
    1385                 1390 


<210>  509
<211>  1327
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  509

Met Lys Ile Ser Lys Val Asn His Met Lys Thr Ala Val Ser Val Arg 
1               5                   10                  15      


Asp Gly Ala Gln Glu Ala Ile Leu Tyr Ala Asp Pro Ser Lys Gly Asn 
            20                  25                  30          


Asp Pro Ile Gln Asp Met Lys Lys Val Tyr Glu Asp Leu Ser Ala Asn 
        35                  40                  45              


Ala Ala Lys Leu Tyr Ser Ile Leu Asn Pro Ala Arg Glu Lys Glu Glu 
    50                  55                  60                  


Lys Arg Ile Ser Ser Leu His Thr Lys Val Asn Ala Leu Ile Lys Glu 
65                  70                  75                  80  


Leu Leu Lys Tyr Trp Val Lys Asp Asp Leu Gln Ala Thr Val Glu Lys 
                85                  90                  95      


Gln Leu Arg Phe Leu Thr Gly Asp Gly Ile Leu Lys Tyr Pro Pro Gln 
            100                 105                 110         


Asn Glu Ala Pro Thr Asp Glu Glu Ile Glu Thr Leu Val Val Gln Cys 
        115                 120                 125             


Leu Arg Lys Ser Leu Arg Ile Asn Val Thr Ala Asn Gly Glu Arg Tyr 
    130                 135                 140                 


Tyr Leu Pro Asp Ile Ala Val Lys Phe Ile Ile Lys Leu Lys Glu Cys 
145                 150                 155                 160 


Trp Glu Lys Gln Glu Lys Val Val Phe Asn Asp Asp Ala Asp Pro Ile 
                165                 170                 175     


Gly Val Gln Glu Ala Glu Ala Phe Leu Arg Ala Val Val Ser Asp Trp 
            180                 185                 190         


Glu Lys Leu Tyr Lys Ser Pro Glu Lys Lys Glu Lys Ile Ile Arg Ser 
        195                 200                 205             


Leu Lys Asn Gln Lys Ala Leu Val Lys Val Ile His Lys Asn Gly Arg 
    210                 215                 220                 


Ser Leu Leu Val Pro Ser Asn Ser Thr His Ala Lys Lys Ala His Val 
225                 230                 235                 240 


Phe Ala Phe Met Arg Ala Tyr Ala Ala Gly Ser Glu Glu Asp Arg Arg 
                245                 250                 255     


Gly Met Leu Ile Ala Met Arg Thr Leu Leu Val Ile Tyr Leu Arg Gly 
            260                 265                 270         


Glu Gly Asp Phe Asn Ser Val Lys Val Ala Glu Asn Ser Phe Leu Cys 
        275                 280                 285             


Glu Phe Ser Pro Glu Asp Phe Leu Asp Ala Gly Val Ser Ala Ala Leu 
    290                 295                 300                 


Glu Arg Val Ser Ala Ile Lys Ser Ser Gln Asp Lys Ala Asp Gly Lys 
305                 310                 315                 320 


Gln Lys Lys Ile Asn Glu Asp Lys Ile Arg Arg Ile Tyr Thr Asp Ile 
                325                 330                 335     


Ile Pro Glu Ile Glu Lys Ile Leu Lys Ser His Tyr Arg Ser Thr Leu 
            340                 345                 350         


Glu Ala Val Ser Glu Asn Asp Phe Leu Ile Asp Glu Val Cys Gly Asp 
        355                 360                 365             


Tyr Cys Ser Asn Leu Leu Asp Gly Glu Glu Pro Lys Ile Ser Ala Leu 
    370                 375                 380                 


Arg Phe Trp Leu Asp Tyr Phe Asp Glu Glu Ala Arg Lys Thr Leu Leu 
385                 390                 395                 400 


Gln Arg Gln Arg Leu Asp Thr Tyr Lys Thr Gly Leu Leu Trp Leu Gly 
                405                 410                 415     


Lys Arg Leu Trp Ser Asn Trp Ile Ser Tyr Ile Ala Leu Lys Phe Ile 
            420                 425                 430         


Asp Tyr Gly Lys Ala Val Tyr His Phe Val Leu Pro Glu Glu Phe Lys 
        435                 440                 445             


Phe Asp Gly Glu Gly Leu Cys Leu Gly Asp Val Leu Pro Asp Tyr Glu 
    450                 455                 460                 


Gly Gly Ile Ser Ser Phe Glu Tyr Glu Arg Leu Lys Ala Arg Asp Asp 
465                 470                 475                 480 


Leu Asp Arg Asn Thr Ala Val Ala Val Thr Phe Ala Val Asn Thr Phe 
                485                 490                 495     


Ser Arg Ala Val Leu Ala Ser Thr Pro Met Lys Trp Asn Asp Arg Lys 
            500                 505                 510         


Asn Gln Glu Glu Pro Val Glu Asp Val Leu Phe Ala Gly Arg Asp Val 
        515                 520                 525             


Tyr Tyr Pro His Leu Tyr Gly Asp Ala Gly Lys Arg Ile Leu Arg Tyr 
    530                 535                 540                 


Phe Gly Gly Ala Ser Asn Trp Glu Asn Asn Asp Glu Ile Ala Leu Tyr 
545                 550                 555                 560 


Ser Ser Glu Asp Lys Gly Ile Glu Ile Ile Val Pro Ile Leu Glu Gln 
                565                 570                 575     


Leu Lys Asp Leu Arg Asn Ser Ser Phe His Tyr Leu Ala Ala Glu Gly 
            580                 585                 590         


Ser Thr Asp Thr Glu Lys Ile Gln Ile Leu Phe Asp Gln Glu Lys Asp 
        595                 600                 605             


Thr Tyr Ser Asp Leu Ile Arg Lys Lys Tyr Phe Ser Asn Asn Val Tyr 
    610                 615                 620                 


Arg Tyr Tyr Ser Glu Asp Asp Ala Lys Glu Phe Leu Gly Phe Val Tyr 
625                 630                 635                 640 


Arg Glu Pro Ala Tyr Val Pro Ala Gln Ile Pro Ala Phe Gln His Leu 
                645                 650                 655     


Phe Asn Arg Asn Ser Ala Phe Met His Asp Arg Ile Ile Lys Gly Asp 
            660                 665                 670         


Ala Lys Arg Lys Ile Ala Gly Ser Gly Thr Asp Glu Leu Arg Ile Tyr 
        675                 680                 685             


Lys Gly Thr Leu Phe Phe Leu Met Lys Glu Ile Tyr Tyr Lys Ala Phe 
    690                 695                 700                 


Leu Gln Asp Pro Gly Cys Lys Asp Arg Phe Met Ala Leu Val Arg Gly 
705                 710                 715                 720 


Glu Asp Pro Asn Ala Ala Val Lys Asn Glu Tyr Ala Leu Gln Asn Phe 
                725                 730                 735     


Arg Lys Arg Ile Glu Thr Leu Gly Glu Asp Ala Asp Leu Gly Glu Ile 
            740                 745                 750         


Cys Gln Leu Ile Met Thr Asp Tyr Glu Leu Gln Asn Lys Asp Lys Arg 
        755                 760                 765             


Val Arg Lys Ser Arg Lys Asn Gly Arg Glu Gln Tyr Arg His Phe Arg 
    770                 775                 780                 


Thr Leu Leu Tyr Tyr Phe Leu Arg Glu Ala Phe Leu Asp Tyr Phe Leu 
785                 790                 795                 800 


Lys Ser Glu Lys Ala Lys Val Phe Ala Phe Ile Arg Glu Pro Asp Ile 
                805                 810                 815     


Lys Glu Asn Trp Lys Asn Lys Thr Leu Glu Gly Tyr Leu Ala Ser Trp 
            820                 825                 830         


Thr Cys Asp Thr Tyr Lys Gly Ile Leu Gln Asp Lys Ser Met Leu Lys 
        835                 840                 845             


Trp Tyr Ala Leu Ala His Phe Leu Thr Pro Lys His Leu Asn His Leu 
    850                 855                 860                 


Ile Gly Ser Tyr Lys Gln Tyr Gly Val Phe Ile Asn Ser Ile Glu Arg 
865                 870                 875                 880 


Arg Ala Gly Asn Thr Gly Asn Arg Thr Asp Asp Val Glu Thr Leu Arg 
                885                 890                 895     


Lys Glu Gly Arg Arg Val Lys Asp Ile Val Asp Met Leu Ala Phe Ser 
            900                 905                 910         


Ala Cys Phe Cys Ala Arg Thr Thr Asn Thr Ala Gly Asp Tyr Phe Lys 
        915                 920                 925             


Asp Asp Glu Glu Tyr Ala Ser Val Ile Ser Asp Phe Val Gln Leu Asp 
    930                 935                 940                 


Lys Lys Tyr Val Asp Ser Asp Met Thr Ala Leu Lys Met Leu Cys Asp 
945                 950                 955                 960 


Lys Glu Leu Glu Leu Ser Thr Gly Lys Lys Asp Lys Asn Gly Lys Lys 
                965                 970                 975     


Cys Lys Ile Lys Gln Arg Ile Gly Ile Tyr Cys Asp Ala Tyr Asn Pro 
            980                 985                 990         


Ile Val Asn Arg Asn Val Val Leu  Ala Ser Met Tyr Gly  Asp Leu Arg 
        995                 1000                 1005             


Met Leu  Ser Val Ile Cys Gly  Arg Ile Thr Glu Ile  Asp Ile Asn 
    1010                 1015                 1020             


Gln Tyr  Tyr Lys Arg Lys Glu  Asp Leu Ser Glu Val  Phe Lys Lys 
    1025                 1030                 1035             


Gly Ala  Cys Ala Ser Ile Asn  Glu Gln Lys Lys Leu  Arg Glu Phe 
    1040                 1045                 1050             


Gln Asp  Ile Lys Asn Arg Ile  Glu Leu His Asp Ile  Leu Thr Phe 
    1055                 1060                 1065             


Thr Glu  Met Val Ser Asp Leu  Asn Gly Gln Leu Val  Asn Trp Ser 
    1070                 1075                 1080             


Tyr Phe  Arg Glu Arg Asp Leu  Met Tyr Met Gln Leu  Gly Val Gln 
    1085                 1090                 1095             


Tyr Thr  Lys Leu Phe Phe Thr  Asp Ala Val Pro Lys  Asp Asp Phe 
    1100                 1105                 1110             


Arg Arg  Lys Ile Val Gly Glu  Arg Phe Ala Phe Thr  Asp Gly Ala 
    1115                 1120                 1125             


Ile Leu  Tyr Gln Ile Thr Ala  Thr Tyr Asp Tyr Arg  Leu Pro Leu 
    1130                 1135                 1140             


Tyr Gly  Phe Gly Gly Asn Gly  Arg Gly Lys Val Ser  Val Lys Ala 
    1145                 1150                 1155             


Gly Val  Pro Ile Ser Ala Cys  Val Ile Gly Phe Val  Glu Lys Tyr 
    1160                 1165                 1170             


Cys Gly  Glu Glu Leu Glu Asn  Lys Asn Thr Val Tyr  Asn Glu Gly 
    1175                 1180                 1185             


Leu Tyr  Phe Phe Glu Asn Ile  Asp Glu His Arg Glu  Leu Val Asp 
    1190                 1195                 1200             


Thr Arg  Asn Tyr Ile Asp His  Phe Lys Tyr Tyr Ala  Asn His Glu 
    1205                 1210                 1215             


Arg Ser  Leu Leu Asp Leu Tyr  Ser Glu Ile Tyr Glu  Arg Phe Phe 
    1220                 1225                 1230             


Asp Tyr  Ser Arg Asn Phe Lys  Lys Ser Val Ser Tyr  Ile Leu Pro 
    1235                 1240                 1245             


Asn Ile  Leu Glu Arg Tyr Phe  Val Val Leu Lys Thr  Glu Ile Glu 
    1250                 1255                 1260             


Lys Gly  Glu Arg Arg Ala Trp  Asn Gly Arg Glu Tyr  Cys Tyr His 
    1265                 1270                 1275             


Asp Ala  Ala Glu Ile Arg Ile  Lys Glu Ile Cys Ser  Ala Asp Phe 
    1280                 1285                 1290             


Thr Tyr  Thr Phe Lys Glu Asp  Gly Lys Asp Val Arg  His Gln Val 
    1295                 1300                 1305             


Pro Ala  His Ser Lys Lys Phe  Leu Glu Thr Val Lys  Arg Ile Leu 
    1310                 1315                 1320             


Glu Tyr  Lys Ala 
    1325         


<210>  510
<211>  1194
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  510

Met Lys Val Thr Lys Ile Asp Gly Leu Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Phe Lys Asn Asn Lys Asn Ile Asn Glu Ile 
            20                  25                  30          


Lys Glu Arg Leu Lys Lys Leu Lys Glu Leu Lys Leu Asp Asn Tyr Ile 
        35                  40                  45              


Lys Asn Pro Glu Asn Val Lys Asn Lys Asp Lys Asp Ala Glu Lys Glu 
    50                  55                  60                  


Thr Lys Ile Arg Arg Thr Asn Leu Lys Lys Tyr Phe Ser Glu Ile Ile 
65                  70                  75                  80  


Leu Arg Lys Glu Asp Glu Lys Tyr Ile Leu Lys Lys Thr Lys Lys Phe 
                85                  90                  95      


Lys Asn Ile Asn Gln Glu Ile Asp Tyr Tyr Asp Val Lys Ser Lys Lys 
            100                 105                 110         


Asn Gln Gln Glu Ile Phe Asp Val Leu Lys Glu Ile Lys Ile Lys Glu 
        115                 120                 125             


Thr Glu Lys Glu Glu Ile Ile Thr Phe Asp Ser Glu Lys Leu Lys Lys 
    130                 135                 140                 


Val Phe Gly Glu Asp Phe Val Lys Lys Glu Ala Lys Ile Lys Ala Ile 
145                 150                 155                 160 


Glu Lys Ser Leu Lys Ile Asn Lys Ala Asn Tyr Lys Lys Asp Ser Ile 
                165                 170                 175     


Lys Ile Gly Asp Asp Lys Tyr Ser Asn Val Lys Gly Glu Asn Lys Arg 
            180                 185                 190         


Ser Arg Ile Tyr Glu Tyr Tyr Lys Lys Ser Glu Asn Leu Lys Lys Phe 
        195                 200                 205             


Glu Glu Asn Ile Arg Glu Ala Phe Glu Lys Leu Tyr Thr Glu Glu Asn 
    210                 215                 220                 


Ile Lys Glu Leu Tyr Ser Lys Ile Glu Glu Val Leu Lys Lys Thr His 
225                 230                 235                 240 


Leu Lys Ser Ile Val Arg Glu Phe Tyr Gln Asn Glu Ile Ile Gly Glu 
                245                 250                 255     


Ser Glu Phe Ser Lys Lys Asn Gly Asp Gly Ile Ser Ile Leu Tyr Asn 
            260                 265                 270         


Gln Ile Lys Asp Ser Ile Lys Lys Glu Glu Asn Phe Ile Glu Phe Ile 
        275                 280                 285             


Glu Asn Ile Gly Asn Leu Lys Leu Lys Asp Leu Thr Lys Ser Gln Ile 
    290                 295                 300                 


Phe Tyr Lys Tyr Phe Leu Glu Asn Glu Glu Leu Asn Asp Glu Asn Ile 
305                 310                 315                 320 


Lys Phe Ala Phe Cys Tyr Phe Val Glu Ile Glu Val Asn Asn Leu Leu 
                325                 330                 335     


Lys Glu Asn Val Tyr Lys Ile Lys Arg Phe Asn Glu Gly Asn Lys Lys 
            340                 345                 350         


Arg Ile Lys Asn Ile Phe Glu Tyr Gly Lys Leu Lys Lys Leu Ile Val 
        355                 360                 365             


Tyr Lys Leu Glu Asn Lys Leu Asn Asn Tyr Val Arg Asn Cys Gly Lys 
    370                 375                 380                 


Tyr Asn Tyr His Met Glu Asn Gly Asp Ile Ala Thr Ser Asp Ile Asn 
385                 390                 395                 400 


Met Arg Asn Arg Gln Thr Glu Ala Phe Leu Arg Ser Ile Ile Gly Val 
                405                 410                 415     


Ser Ser Phe Gly Tyr Phe Ser Leu Arg Asn Ile Leu Gly Val Asn Asp 
            420                 425                 430         


Asp Asp Phe Tyr Glu Ile Glu Glu Gly Leu Thr Glu Glu Glu Arg Lys 
        435                 440                 445             


Asn Glu Ser Asn Val Leu Lys Lys Ala Lys Glu Asp Ile Thr Ser Lys 
    450                 455                 460                 


Ser Ile Phe Glu Lys Val Val Asp Lys Ser Phe Glu Lys Lys Gly Ile 
465                 470                 475                 480 


His Ser Ile Arg Lys Asn Val Lys Met Phe Tyr Gly Asp Ser Phe Asp 
                485                 490                 495     


Lys Ala Asn Glu Asp Glu Leu Lys Gln Phe Phe Val Asn Met Leu Asn 
            500                 505                 510         


Ala Ile Thr Ser Ile Arg His Arg Val Val His Tyr Asn Met Asn Thr 
        515                 520                 525             


Asn Ser Glu Asn Ile Phe Asn Phe Ser Asp Ile Glu Val Ser Arg Leu 
    530                 535                 540                 


Leu Lys Ser Ile Phe Glu Lys Glu Thr Asp Lys Arg Glu Leu Lys Leu 
545                 550                 555                 560 


Lys Ile Phe Arg Gln Leu Asn Ser Ala Gly Val Phe Asp Tyr Trp Glu 
                565                 570                 575     


Asn Trp Lys Ile Glu Lys Tyr Leu Lys Asn Ile Glu Phe Lys Phe Val 
            580                 585                 590         


Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys Leu Tyr Asn Arg 
        595                 600                 605             


Ile Asp Asn Leu Lys Ala Gly Asn Ala Leu Lys Leu Gly Asn His Ile 
    610                 615                 620                 


Ile Ile Pro Lys Arg Lys Glu Ala Arg Asp Ser Gln Ile Tyr Leu Leu 
625                 630                 635                 640 


Lys Asn Ile Tyr Tyr Gly Glu Phe Val Glu Lys Phe Val Asn Asn Asn 
                645                 650                 655     


Asp Asn Phe Glu Lys Ile Phe Arg Glu Ile Ile Lys Ile Asn Lys Asn 
            660                 665                 670         


Ala Gly Thr Asn Thr Lys Thr Lys Phe Tyr Lys Leu Glu Lys Phe Glu 
        675                 680                 685             


Thr Leu Lys Ala Asn Thr Pro Thr Glu Tyr Leu Glu Lys Leu Gln Ser 
    690                 695                 700                 


Leu His Lys Ile Asn Tyr Asp Lys Glu Lys Val Glu Glu Asp Lys Asp 
705                 710                 715                 720 


Thr Tyr Val Asp Phe Val Gln Lys Ile Phe Leu Lys Gly Phe Ile Asn 
                725                 730                 735     


Tyr Leu Gln Lys Ser Asn Ser Leu Lys Pro Leu Asn Leu Leu Asn Leu 
            740                 745                 750         


Lys Lys Asp Glu Val Ile Asn Ser Glu Lys Ser Ser Tyr Asp Glu Lys 
        755                 760                 765             


Leu Lys Gln Trp Glu Asn Asn Gly Ser Lys Leu Ser Glu Met Pro Lys 
    770                 775                 780                 


Glu Ile Tyr Glu Tyr Ile Lys Lys Ile Gln Ile Asn Lys Ile Asn Tyr 
785                 790                 795                 800 


Ser Asn Arg Met Ser Ile Phe Tyr Leu Leu Leu Lys Leu Ile Asp His 
                805                 810                 815     


Arg Glu Leu Thr Asn Leu Arg Gly Asn Leu Glu Lys Tyr Glu Ser Met 
            820                 825                 830         


Asn Lys Asn Glu Ile Tyr Ser Glu Glu Leu Asn Ile Val Asn Leu Val 
        835                 840                 845             


Ser Leu Asp Asn Asn Lys Val Arg Ala Asn Phe Asn Leu Glu Ser Glu 
    850                 855                 860                 


Asp Ile Gly Lys Phe Leu Lys Thr Glu Thr Ser Ile Lys Asn Ile Asn 
865                 870                 875                 880 


Gln Leu Asn Asn Phe Ser Gly Ile Phe Ala Asp Gly Glu Asn Val Ile 
                885                 890                 895     


Lys His Arg Ser Phe Tyr Asn Ile Lys Lys Tyr Gly Ile Leu Asp Leu 
            900                 905                 910         


Leu Glu Lys Ile Val Ala Lys Ala Asp Leu Lys Ile Ala Lys Glu Glu 
        915                 920                 925             


Ile Lys Lys Tyr Glu Asn Leu Gln Asn Glu Leu Lys Arg Asn Asp Phe 
    930                 935                 940                 


Tyr Lys Ile Gln Glu Lys Ile His Arg Lys Tyr Asn Gln Lys Pro Asn 
945                 950                 955                 960 


Leu Ile Leu Arg Thr Glu Asn Lys Lys Asp Phe Asn Asp Tyr Lys Lys 
                965                 970                 975     


Ala Ile Glu Asn Ile Gln Asn Tyr Thr Gln Leu Lys Asn Lys Ile Glu 
            980                 985                 990         


Phe Asn Asp Leu Asn Leu Leu Gln  Gly Leu Leu Phe Arg  Ile Leu His 
        995                 1000                 1005             


Arg Leu  Ala Gly Tyr Thr Ser  Leu Trp Glu Arg Asp  Leu Gln Phe 
    1010                 1015                 1020             


Lys Leu  Lys Gly Glu Phe Pro  Glu Asp Lys Tyr Ile  Asp Glu Ile 
    1025                 1030                 1035             


Phe Asn  Ser Asp Arg Asn Asn  Asn Gln Lys Tyr Lys  Ser Gly Gly 
    1040                 1045                 1050             


Ile Ala  Tyr Lys Tyr Val Asp  Phe Leu Ile Glu Lys  Glu Glu Gly 
    1055                 1060                 1065             


Lys Arg  Ala Gly Lys Asn Lys  Val Lys Lys Arg Ser  Glu Lys Glu 
    1070                 1075                 1080             


Gly Ser  Phe Ile Ile Arg Asn  Tyr Ile Ala His Phe  Asn Tyr Ile 
    1085                 1090                 1095             


Pro Asp  Ala Glu Lys Ser Ile  Leu Glu Ile Leu Glu  Glu Leu Arg 
    1100                 1105                 1110             


Glu Leu  Leu Lys Tyr Asp Arg  Lys Leu Lys Asn Ala  Val Met Lys 
    1115                 1120                 1125             


Ser Val  Lys Asp Ile Phe Lys  Glu Tyr Gly Phe Ile  Val Glu Phe 
    1130                 1135                 1140             


Arg Ile  Ser His Glu Ser Asn  Ser Lys Lys Ile Lys  Val Leu Asp 
    1145                 1150                 1155             


Val Lys  Ser Glu Lys Ile Lys  His Leu Lys Asn Asn  Gly Leu Val 
    1160                 1165                 1170             


Thr Thr  Lys Asn Ser Glu Asp  Leu Cys Glu Leu Val  Lys Val Met 
    1175                 1180                 1185             


Leu Glu  Tyr Lys Lys Ser 
    1190                 


<210>  511
<211>  1150
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  511

Met Lys Ile Thr Lys Ile Asp Gly Ile Ser His Lys Lys Tyr Lys Glu 
1               5                   10                  15      


Lys Gly Lys Leu Ile Lys Ser Asn Glu Ile Glu Lys Asp Ile Thr Glu 
            20                  25                  30          


Glu Arg Phe Asn Asp Ile Glu Ala Lys Thr Thr Glu Leu Phe Gln Lys 
        35                  40                  45              


Thr Leu Asp Phe Tyr Val Lys Asn Tyr Glu Asn Ser Glu Asp Gln Asn 
    50                  55                  60                  


Lys Glu Arg Arg Glu Lys Ala Lys Asn Tyr Phe Ser Lys Val Lys Ile 
65                  70                  75                  80  


Leu Val Asp Asn Lys Lys Ile Thr Ile Cys Asn Glu Asn Thr Glu Lys 
                85                  90                  95      


Met Glu Ile Glu Asp Phe Asn Glu Tyr Asp Val Arg Asn Arg Lys Phe 
            100                 105                 110         


Phe Asn Val Leu Asn Lys Ile Leu Asn Arg Glu Asn Cys Thr Glu Glu 
        115                 120                 125             


Asp Leu Glu Val Phe Glu Asn Asp Leu Gln Lys Arg Ile Gly Arg Ile 
    130                 135                 140                 


Lys Ser Ile Lys Asn Ser Leu Glu Glu Asn Lys Ala His Phe Lys Lys 
145                 150                 155                 160 


Glu Ser Ile Asn Asn Asn Ile Asn Tyr Asp Lys Val Lys Gly Asn Asn 
                165                 170                 175     


Lys Arg Ser Ile Phe Tyr Glu Tyr Tyr Lys Asn Ser Leu Lys His Gln 
            180                 185                 190         


Glu Tyr Ile Asn Asn Ile Phe Glu Ala Phe Asp Lys Leu Tyr Ser Asn 
        195                 200                 205             


Ser His Glu Ala Met Asn Asn Leu Phe Ser Glu Ile Thr Lys Asp Ser 
    210                 215                 220                 


Lys Asp Arg Asn Ile Arg Lys Ile Arg Glu Ala Tyr His Glu Ile Leu 
225                 230                 235                 240 


Asn Lys Asn Lys Thr Glu Phe Gly Glu Glu Leu Tyr Lys Lys Ile Gln 
                245                 250                 255     


Asp Asn Arg Asn Asn Phe Asp Lys Leu Leu Glu Ile Glu Pro Glu Ile 
            260                 265                 270         


Lys Glu Leu Thr Lys Ser Gln Ile Phe Tyr Lys Tyr Tyr Ile Asp Lys 
        275                 280                 285             


Val Asn Leu Asp Glu Thr Ser Ile Lys His Cys Phe Cys His Leu Val 
    290                 295                 300                 


Glu Ile Glu Val Asn Gln Leu Leu Lys Asn Tyr Val Tyr Ser Lys Arg 
305                 310                 315                 320 


Asn Ile Asn Lys Glu Lys Leu Glu Asn Ile Phe Glu Tyr Cys Lys Leu 
                325                 330                 335     


Arg Asn Leu Val Lys Asn Lys Leu Val Asn Lys Leu Asn Asn Tyr Ile 
            340                 345                 350         


Arg Asn Cys Gly Lys Tyr Asn Ala Tyr Ile Ser Asn Asn Asp Val Val 
        355                 360                 365             


Val Asn Ser Glu Lys Ile Ser Glu Ile Arg Thr Lys Glu Ala Phe Leu 
    370                 375                 380                 


Arg Ser Ile Ile Gly Val Ser Ser Ser Ala Tyr Phe Ser Leu Arg Asn 
385                 390                 395                 400 


Ile Leu Asn Thr Asp Asn Thr Gln Asp Ile Thr Asn Lys Val Asp Lys 
                405                 410                 415     


Glu Val Asp Lys Leu Tyr Gln Glu Asn Lys Lys Ile Glu Leu Glu Glu 
            420                 425                 430         


Ile Leu Lys Leu Phe Phe Gly Asn Tyr Phe Asp Ile Asn Asn Gln Gln 
        435                 440                 445             


Glu Ile Lys Val Phe Leu Met Asn Ile Asp Lys Ile Ile Ser Ser Ile 
    450                 455                 460                 


Arg His Glu Ile Ile His Phe Lys Met Glu Thr Asn Ala Gln Asn Ile 
465                 470                 475                 480 


Phe Asp Phe Asn Asn Val Asn Leu Gly Asn Thr Ala Lys Asn Ile Phe 
                485                 490                 495     


Ser Asn Glu Ile Asn Glu Glu Lys Ile Lys Phe Lys Ile Phe Lys Gln 
            500                 505                 510         


Leu Asn Ser Ala Asn Val Phe Asp Tyr Leu Ser Asn Lys Asp Ile Thr 
        515                 520                 525             


Glu Tyr Met Asp Lys Val Val Phe Ser Phe Thr Asn Arg Asn Val Ser 
    530                 535                 540                 


Phe Val Pro Ser Phe Thr Lys Ile Tyr Asn Arg Val Gln Asp Leu Ala 
545                 550                 555                 560 


Asn Ser Leu Glu Ile Lys Glu Trp Lys Ile Pro Asp Glu Ser Glu Gly 
                565                 570                 575     


Lys Asp Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Lys Phe 
            580                 585                 590         


Leu Asp Lys Phe Leu Asn Glu Glu Asn Gly Ile Phe Ile Ser Ile Lys 
        595                 600                 605             


Asp Lys Ile Ile Glu Leu Asn Lys Asn Gln Asn Glu Asp Lys His Cys 
    610                 615                 620                 


Lys Phe Lys Lys Phe Glu Ser Val Asn Glu Lys Asn Pro Lys Lys Tyr 
625                 630                 635                 640 


Leu Glu Ile Ile Gln Ser Leu Tyr Met Ile Asn Ile Glu Lys Ile Asn 
                645                 650                 655     


Ser Glu Arg Lys Asn Val Phe Leu Asp Phe Ile Gln Arg Ile Phe Leu 
            660                 665                 670         


Lys Gly Phe Phe Glu Phe Ile Lys Asn Asp Tyr Asn Tyr Leu Leu Glu 
        675                 680                 685             


Leu Lys Lys Val Gln Asp Lys Lys Asn Ile Phe Asp Ser Lys Met Ser 
    690                 695                 700                 


Glu Tyr Ile Ala Gly Glu Lys Thr Leu Glu Tyr Met Glu Glu Ile Asn 
705                 710                 715                 720 


Glu Ile Ile Gln Asp Ile Lys Ile Thr Glu Ile Asp Lys Ile Leu Asn 
                725                 730                 735     


Gln Thr Asp Lys Ile Asn Cys Phe Tyr Leu Leu Leu Lys Leu Leu Asn 
            740                 745                 750         


Tyr Lys Glu Ile Thr Glu Leu Lys Gly Asn Leu Glu Lys Tyr Gln Ile 
        755                 760                 765             


Leu Ser Lys Thr Asn Val Tyr Glu Lys Glu Leu Met Leu Leu Asn Ile 
    770                 775                 780                 


Val Asn Leu Asp Asn Asn Lys Val Lys Ile Glu Asn Phe Lys Ile Ser 
785                 790                 795                 800 


Ala Glu Glu Ile Gly Lys Phe Ile Glu Lys Ile Asn Ile Glu Glu Ile 
                805                 810                 815     


Asn Lys Lys Ile Lys Thr Phe Glu Glu Leu Arg Asn Phe Glu Lys Gly 
            820                 825                 830         


Glu Asn Thr Gly Glu Tyr Tyr Asn Ile Tyr Ser Asp Asp Lys Asn Ile 
        835                 840                 845             


Lys Asn Ile Arg Asn Leu Tyr Asn Ile Lys Lys Tyr Gly Met Leu Asp 
    850                 855                 860                 


Leu Leu Glu Lys Ile Ser Glu Lys Thr Asn Tyr Cys Ile Lys Lys Lys 
865                 870                 875                 880 


Asp Leu Glu Glu Tyr Ser Lys Leu Arg Lys Gln Leu Glu Asp Lys Lys 
                885                 890                 895     


Lys Glu Asn Glu Lys Ile Glu Asp Glu Lys Thr Asn Phe Tyr Lys Ile 
            900                 905                 910         


Gln Glu Tyr Leu His Ser Lys Tyr Gln Gln Glu Pro Lys Lys Ile Leu 
        915                 920                 925             


Trp Lys Asn Asn Lys Asn Asp Tyr Glu Lys Tyr Lys Lys Ser Ile Glu 
    930                 935                 940                 


Asn Ile Glu Lys Tyr Val His Leu Lys Asn Lys Ile Glu Phe Asn Glu 
945                 950                 955                 960 


Leu Asn Leu Leu Gln Ser Leu Leu Leu Lys Ile Leu His Arg Leu Val 
                965                 970                 975     


Gly Phe Thr Ser Ile Trp Glu Arg Asp Leu Arg Phe Arg Leu Thr Gly 
            980                 985                 990         


Glu Phe Pro Asp Glu Leu Asp Ile  Glu Asp Ile Phe Asp  His Arg Lys 
        995                 1000                 1005             


Arg Tyr  Lys Gly Thr Gly Gly  Gly Ile Cys Lys Lys  Tyr Asp Arg 
    1010                 1015                 1020             


Phe Ile  Asn Thr Tyr Thr Glu  Tyr Lys Asn Asn Asn  Lys Met Lys 
    1025                 1030                 1035             


Asn Val  Lys Phe Ala Asp Asn  Asn Pro Val Arg Asn  Tyr Ile Ala 
    1040                 1045                 1050             


His Phe  Asn Tyr Leu Pro Asn  Pro Lys Tyr Ser Ile  Leu Lys Met 
    1055                 1060                 1065             


Met Glu  Lys Leu Arg Lys Leu  Leu Asp Tyr Asp Arg  Lys Leu Lys 
    1070                 1075                 1080             


Asn Ala  Val Met Lys Ser Ile  Lys Asp Ile Leu Glu  Glu Tyr Gly 
    1085                 1090                 1095             


Phe Lys  Ala Glu Phe Ile Ile  Asn Ser Asp Lys Glu  Ile Ile Leu 
    1100                 1105                 1110             


Asn Pro  Val Lys Ser Val Glu  Ile Ile His Leu Gly  Lys Glu Asp 
    1115                 1120                 1125             


Leu Lys  Ser Arg Arg Asn Ser  Glu Asp Leu Cys Lys  Leu Val Lys 
    1130                 1135                 1140             


Ala Met  Leu Glu Tyr Ser Glu  
    1145                 1150 


<210>  512
<211>  1407
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  512

Met Gly Asn Leu Phe Gly Tyr Lys Lys Trp Tyr Lys Val Asp Lys Ile 
1               5                   10                  15      


Ile Lys Asp Lys Lys Gly Lys Lys Ser Thr Ile Lys Gln Glu Val Arg 
            20                  25                  30          


Ile Lys Arg Asp Tyr Leu Thr Asn Arg Tyr Ile Leu Asn Thr Asn Asn 
        35                  40                  45              


Lys Asp Lys Asn Asn Ile Asn Asn Lys Asp Phe Val Asn Gln Phe Ile 
    50                  55                  60                  


Glu Tyr Lys Thr Lys Asn Asp Ile Phe Glu Lys Phe Thr Arg Lys Phe 
65                  70                  75                  80  


His Met Gly Asn Ile Leu Phe Lys Leu Lys Ala Lys Glu Ser Val Gly 
                85                  90                  95      


Glu Ile Arg Ser Tyr Asn Asn Phe Leu Glu Lys Glu Lys Ala Ile Leu 
            100                 105                 110         


Glu Ile Glu Ile Tyr Gln Gln Ser Glu Glu Leu Arg Lys Lys Glu Asn 
        115                 120                 125             


Ile Thr Lys Lys Asp Ile Ile Asp Lys Val Ile Glu Asp Lys Ile Thr 
    130                 135                 140                 


Glu Asn Ser Asn Glu Ile Lys Met Gln Ile Lys Leu Glu Lys Asn Asn 
145                 150                 155                 160 


Phe Glu Glu Ile Arg Ile Tyr Ile Asn Lys Glu Leu Gly Gln Tyr Asn 
                165                 170                 175     


Ile Lys Leu Lys Asn Ile Asp Asn Asp Glu Leu Asn Leu Lys Arg Glu 
            180                 185                 190         


Thr Tyr Glu Ile Leu Lys Ser Ile Asn Ala Asn Leu Tyr Ile Ile Thr 
        195                 200                 205             


Lys Asn Ala Ile Ser Asn Ala Asn Phe Glu Lys Arg Asn Tyr Glu Ile 
    210                 215                 220                 


Phe Leu Lys Lys Ser Met Arg Lys Tyr Leu Arg Glu Asn Ile Asn Lys 
225                 230                 235                 240 


Lys Leu Arg Asn Thr Phe Leu Glu Ser Leu Ser Lys Ser Leu Lys Lys 
                245                 250                 255     


Ile Gln Asn Asn Ile Arg Glu Asn Glu Glu Ile Ile Asn Phe Ile Lys 
            260                 265                 270         


Tyr Tyr Ser Ser Ile Asn Gly Asn Lys Thr Val Ser Glu Asn Lys Lys 
        275                 280                 285             


Thr Phe Leu Glu Lys Ile Leu Asn Thr Glu Val Ser Ile Ser Glu Asn 
    290                 295                 300                 


Asp Ile Ile Asp Phe Ile Ile Gly Glu Leu Lys Phe Tyr Gly Ile Ile 
305                 310                 315                 320 


Lys Arg Ile Glu Glu Leu Gln Glu Lys Thr Ile Asp Arg Thr Glu Glu 
                325                 330                 335     


Asp Ile Lys Asn Thr Tyr Ile Asn Thr Tyr Val Ser Leu Asp Lys His 
            340                 345                 350         


Glu Lys Phe Lys Ile Asp Arg Glu Asn Lys Lys Asp Lys Val Val Lys 
        355                 360                 365             


Leu Phe Val Lys Asp Ile His Asn Asn Thr Met Glu Glu Lys Ile Asn 
    370                 375                 380                 


Asp Ile Leu Ser Lys Phe Lys Ile Lys Glu Leu Thr Lys Lys Leu Glu 
385                 390                 395                 400 


Lys Asn Thr Glu Asn Lys Asn Phe Asp Thr Glu Ile Phe Gly Ile Phe 
                405                 410                 415     


Lys Lys His Tyr Lys Val Asn Phe Asp Ser Lys Lys Phe Ser Asn Lys 
            420                 425                 430         


Ser Asp Glu Glu Lys Glu Leu Tyr Lys Ile Ile Tyr Arg Tyr Leu Lys 
        435                 440                 445             


Gly Arg Ile Glu Lys Ile Leu Ile Asn Glu Glu Lys Val Arg Leu Lys 
    450                 455                 460                 


Lys Met Glu Lys Ile Glu Ile Glu Lys Ile Leu Asn Glu Ser Ile Leu 
465                 470                 475                 480 


Ser Glu Lys Ile Leu Lys Arg Val Lys Gln Tyr Thr Leu Glu His Ile 
                485                 490                 495     


Met Tyr Leu Gly Lys Leu Val His Asn Asn Ile Asp Met Thr Thr Val 
            500                 505                 510         


Asn Thr Asn Asp Phe Ser Lys Leu His Ala Lys Glu Glu Leu Asp Leu 
        515                 520                 525             


Glu Leu Ile Thr Phe Phe Ala Ser Thr Asn Met Glu Leu Asn Lys Ile 
    530                 535                 540                 


Phe Ser Arg Glu Asn Ile Asn Asn Asp Glu Asn Ile Asp Phe Phe Gly 
545                 550                 555                 560 


Gly Asp Arg Glu Lys Asn Tyr Val Leu Asp Lys Lys Asn Leu Asn Ser 
                565                 570                 575     


Lys Ile Lys Ile Ile Arg Asp Leu Asp Phe Ile Asp Asn Lys Asn Asn 
            580                 585                 590         


Ile Thr Asn Asp Phe Ile Asn Lys Phe Thr Lys Ile Gly Thr Asn Glu 
        595                 600                 605             


Arg Asn Arg Ile Leu His Ala Ser Gly Lys Lys Arg Asp Ser Gln Gly 
    610                 615                 620                 


Thr Gln Asp Asp Tyr Asn Lys Val Ile Asn Ile Ile Gln Asn Leu Lys 
625                 630                 635                 640 


Ile Ser Asp Glu Glu Val Ser Lys Val Leu Asn Leu Asp Val Val Phe 
                645                 650                 655     


Lys Asp Lys Lys Asn Ile Ile Thr Glu Ile Asn Asp Ile Lys Ile Ser 
            660                 665                 670         


Glu Lys Asn Ser Asn Asp Ile Lys Tyr Leu Pro Ser Phe Ser Lys Val 
        675                 680                 685             


Leu Pro Glu Ile Leu Asn Leu Tyr Arg Asn Asn Pro Lys Asn Glu Pro 
    690                 695                 700                 


Phe Asp Thr Ile Glu Thr Glu Lys Ile Val Leu Asn Ala Leu Ile Tyr 
705                 710                 715                 720 


Val Asn Lys Glu Leu Tyr Lys Lys Leu Ile Leu Glu Asp Asp Leu Gln 
                725                 730                 735     


Glu Asn Arg Ser Lys Asn Ile Phe Leu Gln Glu Leu Lys Lys Thr Leu 
            740                 745                 750         


Gly Asn Ile Asp Glu Thr Asp Glu Asn Ile Ile Glu Asn Tyr Tyr Lys 
        755                 760                 765             


Asn Ala Gln Ile Ser Ala Ser Lys Gly Asn Asn Lys Ala Ile Lys Lys 
    770                 775                 780                 


Tyr Gln Lys Lys Val Ile Glu Tyr Tyr Ile Gly Tyr Leu Arg Lys Asn 
785                 790                 795                 800 


Tyr Glu Glu Leu Phe Asp Phe Ser Asp Phe Lys Met Asn Ile Gln Glu 
                805                 810                 815     


Ile Lys Lys Gln Ile Lys Asp Ile Asn Asp Asn Lys Thr Tyr Glu Arg 
            820                 825                 830         


Ile Thr Ile Lys Thr Ser Asp Lys Ser Ile Val Ile Asn Asp Asp Phe 
        835                 840                 845             


Glu Tyr Ile Ile Ser Ile Phe Ala Leu Leu Asn Ser Asn Thr Val Ile 
    850                 855                 860                 


Asn Lys Ile Arg Asn Arg Phe Phe Ala Thr Ser Val Trp Leu Asp Thr 
865                 870                 875                 880 


Ser Glu Tyr Gln Asn Ile Ile Asn Ile Leu Asp Glu Ile Met Gln Leu 
                885                 890                 895     


Asn Thr Leu Arg Asn Glu Cys Ile Thr Glu Asn Trp Asn Leu Asn Leu 
            900                 905                 910         


Glu Glu Phe Ile Gln Lys Met Lys Glu Ile Glu Lys Asp Phe Asp Asp 
        915                 920                 925             


Phe Lys Ile Gln Thr Lys Lys Asp Ile Phe Asn Gly Asn Tyr Glu Ser 
    930                 935                 940                 


Ile Lys Asn Asn Val Leu Ser Lys Phe Ile Gly Phe Ser Asp Val Gln 
945                 950                 955                 960 


Lys Ile Leu Glu Glu Lys Leu Asn Asn Leu Ile Asp Phe Glu Asn Asp 
                965                 970                 975     


Asn Glu Ile Lys Lys Ser Leu Asn Leu Asp Ser Leu Asn Pro Asp Glu 
            980                 985                 990         


Arg Arg Asn Leu Met Pro Asn Ile  Asn Pro Lys Lys Gly  Gly Ile Asp 
        995                 1000                 1005             


Leu Ile  Lys Glu Ile Asp Lys  Leu Ile Val Ile Lys  Lys Asn Asn 
    1010                 1015                 1020             


Ile Glu  Lys Asn Ile Leu Leu  Lys Ile Ile Phe Asn  Ser Asp Phe 
    1025                 1030                 1035             


Leu Glu  Lys Tyr Lys Lys Glu  Ile Asp Asn Leu Leu  Glu Asp Thr 
    1040                 1045                 1050             


Glu Thr  Glu Asn Lys Asn Lys  Phe Glu Lys Ile Tyr  Tyr Pro Glu 
    1055                 1060                 1065             


Glu His  Lys Asn Glu Leu Tyr  Ile Tyr Lys Lys Asn  Leu Phe Leu 
    1070                 1075                 1080             


Asn Ile  Gly Asn Pro Asn Phe  Asp Lys Ile Tyr Gly  Leu Ile Ser 
    1085                 1090                 1095             


Asn Asp  Ile Lys Met Ala Asp  Ala Lys Phe Leu Phe  Asp Ser Asp 
    1100                 1105                 1110             


Ser Lys  Asp Ile Arg Asn Asn  Glu Ile Ser Lys Ile  Asp Gly Ile 
    1115                 1120                 1125             


Leu Lys  Asn Leu Asn Asp Lys  Leu Asn Gly Tyr Ser  Lys Glu Tyr 
    1130                 1135                 1140             


Lys Glu  Lys Tyr Val Lys Lys  Leu Lys Glu Ser Asn  Asp Phe Phe 
    1145                 1150                 1155             


Ala Lys  Asn Ile Gln Asn Glu  Asn Tyr Ser Ser Phe  Glu Glu Phe 
    1160                 1165                 1170             


Glu Lys  Asn Tyr Asn Lys Ile  Ser Glu Tyr Lys Lys  Ile Arg Asp 
    1175                 1180                 1185             


Leu Val  Glu Phe Asn Tyr Leu  Asn Lys Ile Glu Ser  Tyr Leu Ile 
    1190                 1195                 1200             


Asp Ile  Asn Trp Lys Leu Ala  Ile Gln Met Ala Arg  Phe Glu Arg 
    1205                 1210                 1215             


Asp Met  His Tyr Ile Val Asn  Gly Leu Asp Tyr Leu  Tyr Ile Ile 
    1220                 1225                 1230             


Arg Leu  Glu Lys Asp Arg Asn  Gln Asp Arg Ser Ser  Pro Tyr Pro 
    1235                 1240                 1245             


Lys Tyr  Lys Asn Gly Val Leu  Asp Tyr Thr Lys Ser  Tyr Tyr Asn 
    1250                 1255                 1260             


Phe Lys  Asp Tyr Gln Glu Phe  Met Asp Ile Cys Ser  Lys Phe Gly 
    1265                 1270                 1275             


Ile Asp  Leu Ser Glu Asn Ser  Glu Ile Asn Lys Pro  Glu Ser Glu 
    1280                 1285                 1290             


Ser Ile  Arg Asn Tyr Ile Ser  His Phe Tyr Ile Val  Arg Asn Pro 
    1295                 1300                 1305             


Phe Val  Asp Tyr Ser Ile Ala  Glu Gln Ile Asp Arg  Val Ser Asn 
    1310                 1315                 1320             


Leu Leu  Ser Tyr Ser Thr Arg  Tyr Asn Asn Ser Thr  Tyr Ala Ser 
    1325                 1330                 1335             


Val Phe  Glu Val Phe Lys Lys  Asp Val Asn Leu Asp  Tyr Asp Glu 
    1340                 1345                 1350             


Leu Lys  Lys Lys Phe Lys Leu  Ile Gly Asn Asn Asp  Ile Leu Glu 
    1355                 1360                 1365             


Lys Leu  Met Lys Ser Lys Lys  Val Ser Val Leu Glu  Leu Glu Ser 
    1370                 1375                 1380             


Tyr Asn  Ser Asp Tyr Val Lys  Asn Leu Ile Ile Lys  Leu Leu Thr 
    1385                 1390                 1395             


Lys Ile  Glu Lys Thr Asn Asp  Thr Leu 
    1400                 1405         


<210>  513
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  513

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Pro Gly Thr Asp Thr 
            20                  25                  30          


Ile Asp Leu Lys Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Asp Lys Pro Lys Lys 
    50                  55                  60                  


Trp Lys Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Glu Tyr Val Lys Asn Ser Gln Glu Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Asp Ser Gln Gly Thr Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Gly Phe Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys His 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ser Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ser Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Phe 
            660                 665                 670         


Val Arg Lys Asn Phe Pro Glu Asp Ile Thr Asn Val Phe Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Lys Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Tyr 
                805                 810                 815     


Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Gly Trp Thr Ser Thr 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Leu Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Arg Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Gly  Asp Ile Glu Glu Phe  Tyr Asp Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Asp Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Met  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Glu Tyr Glu Lys Ile  Glu Ile Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Gly Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Val  Tyr Ala Pro Glu Lys  Gly Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Ile Gly  Val Lys Val 
    1145                 1150                 1155             


Asp Ala  Phe Lys Arg Tyr Ser  Glu His Leu Gly Leu  His Lys Glu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Ile  Ile Glu Glu 
    1175                 1180                 1185             


His Glu  Asp Val Ile Asn Leu  Arg Asn Ser Ile Asn  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Lys Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Met Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Tyr Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Phe Glu Ser  Gly Val Lys Thr Ile  Gly Asp Gln 
    1250                 1255                 1260             


Thr Lys  Pro Cys Ala Lys Leu  Ser Ile Lys Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Glu Tyr Lys Val Lys  Gly Gly Thr Leu Val  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Asp  Asp Glu Asp Ser Asn  Ala Lys Lys Pro Ala  Ile Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Gly Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Pro Asn 
    1370                 1375                 1380         


<210>  514
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  514

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Leu Tyr Gln Ile Val  Ser Ala Phe Asn Phe  Gly Ser Lys 
    1205                 1210                 1215             


Leu Leu  Tyr Ile Ser Glu Asp  Gly Arg Trp Lys Met  Ala Gly Gly 
    1220                 1225                 1230             


Ala Phe  Pro Gly Lys Tyr Gly  Arg Phe Glu Asn Asp  Tyr Asn His 
    1235                 1240                 1245             


Arg Thr  Ser Leu Ser Lys Val  Ile Arg Leu Phe Glu  Asn Glu Ser 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ile Ile Tyr  Trp Arg Asp Tyr Val  Asp His Met 
    1265                 1270                 1275             


Lys Tyr  Tyr Val Asn Gln Asn  Gln Ser Ile Met Glu  Ile Tyr Ser 
    1280                 1285                 1290             


Ala Phe  Tyr Ser Lys Val Leu  Gly Tyr Ser Ala Lys  Leu Arg Lys 
    1295                 1300                 1305             


Ser Val  Val Phe Asn Leu Gln  Ala Ala Leu Glu Lys  His His Ile 
    1310                 1315                 1320             


Asn Pro  Glu Cys Ile Trp Met  Thr Ser Asp Gly Lys  Cys Ala Asp 
    1325                 1330                 1335             


Ile Lys  Leu Met Lys Asn Leu  Glu Ser Gln Lys Phe  Thr Tyr Lys 
    1340                 1345                 1350             


Leu Ala  Lys Arg Glu Gly Glu  Lys Thr Glu Arg Lys  Ile Cys Met 
    1355                 1360                 1365             


Asn Ala  Leu Asn Glu Asn Phe  Leu Lys Thr Ile Arg  Thr Ser Leu 
    1370                 1375                 1380             


Glu Tyr  Lys Lys 
    1385         


<210>  515
<211>  1373
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  515

Met Ala Lys His Leu Arg Pro Ile Gly Glu Ser Tyr Thr Asp Phe Leu 
1               5                   10                  15      


Asp Glu Thr Glu Phe Val Arg Leu Gly Arg Gly Leu His Arg Gly His 
            20                  25                  30          


His Gly Val Gln Ile Pro Pro Thr Glu Leu Pro Ser Tyr Leu Ala Glu 
        35                  40                  45              


Tyr Arg Lys Ala Leu Met Arg Gln Val Val Ala Val Leu Asp Lys Val 
    50                  55                  60                  


Val Gly Lys Arg Arg Arg Leu Ser Gly Met His Pro Glu Ala Tyr Arg 
65                  70                  75                  80  


Asp Arg Val His Leu Ala Glu Ala Leu Trp Val Arg Leu Val Ala Arg 
                85                  90                  95      


Val Lys Glu Ile Gly Thr Pro Pro Asp Pro Ser Glu Leu Leu Asp Leu 
            100                 105                 110         


Arg Arg Met Trp Asn Ala Lys Ala His Pro Tyr Ala Glu Tyr Asp Val 
        115                 120                 125             


Val Pro Arg Ala Pro Leu Asn Asp Gly Asn Gly Gln Lys Ile Leu Glu 
    130                 135                 140                 


Cys Arg Glu Val Asp Asp Pro Lys Ile Glu Arg Ser Asp Phe Glu Gly 
145                 150                 155                 160 


Arg Trp His Gly Arg Phe Trp Gln Ser Glu Pro Gly Pro Val Asp Tyr 
                165                 170                 175     


Asn Ala Ile Ala Asp Arg Ile Phe Ala His Leu Phe Asp Gln Glu Ala 
            180                 185                 190         


Val Ile Gly Gly Gly Pro Arg Arg Glu Gly Asn Val Thr Val Pro Asp 
        195                 200                 205             


Glu Asp Ile Asn Gly Gln Pro Gly Pro Ala Thr Gly Lys Gly Leu Ile 
    210                 215                 220                 


Ile Ala Arg Gly Gln Ser Ile Val Lys Ser Ala Ser Asp Pro Arg Arg 
225                 230                 235                 240 


Ser Ser Lys Lys Val Gln Arg Thr Trp Asp Lys Ala Val Glu Arg Arg 
                245                 250                 255     


Tyr Phe Gly Asp Asp Gly Lys Gly Gly Ser Asp Ile Ala Lys Ala Ile 
            260                 265                 270         


Tyr Glu Glu Leu Gly Asp Pro Ala Thr Leu Ala Asp Pro Ile Tyr Ala 
        275                 280                 285             


Ser Trp Phe Gly Ser Arg Leu Tyr Asp His Phe Gly Ser Phe Lys Asn 
    290                 295                 300                 


Ser Leu Pro Leu Glu Leu Lys Asp Pro Phe Lys Glu Gln Ile Trp Ala 
305                 310                 315                 320 


Leu His Asn Ser Val Arg Gln Phe Tyr Gln Arg Met Ala Lys Ser Asp 
                325                 330                 335     


Arg Phe Arg Leu Ala Leu Gln Asn Ala Arg Ser Glu Val Pro Asp Arg 
            340                 345                 350         


Ser Glu Leu Leu Ala Leu Leu Pro Lys Asp His Asp His Leu Leu Leu 
        355                 360                 365             


Val Leu Gly Gly Lys Lys Lys Asn Ala Glu Met Ser Glu Leu Ile Arg 
    370                 375                 380                 


Leu Gly Lys Leu Phe Val His Ala Ser Asp Val Leu His Asp Phe Asp 
385                 390                 395                 400 


Ala Asn Asp Ala Ala Ala Leu Asp Ala Phe Lys Arg Arg Met Ser Phe 
                405                 410                 415     


Leu Ala Thr Ser Ile Gly Gln Ser Glu Ile Lys Gln Thr Glu Thr Phe 
            420                 425                 430         


Ala Arg Thr Trp Arg Gly Ala Val Gly Leu Thr Leu Arg Thr Val Lys 
        435                 440                 445             


Gly Leu Ala Asp Pro Arg Gly Ile Ile Gly Thr Pro Asp Asn Arg Asp 
    450                 455                 460                 


Leu Gly Thr Ala Gly Pro Met Lys Asp Ala Phe Asn Lys Phe Asp Gln 
465                 470                 475                 480 


Pro His Phe Gln Gln His Met Thr Ile Ile Phe Gly Asn Lys Glu Leu 
                485                 490                 495     


Gln Ala Glu Gly Asn Pro Thr Arg Ser Ser Val Phe Thr Ala Asn Gly 
            500                 505                 510         


Asp Lys Asp His Gln Ala Glu Leu Leu Trp Gly Phe Leu Cys Val Val 
        515                 520                 525             


Arg Ser Val Arg Asn Arg Thr Asn His Tyr Asn Val Arg Arg Ala Leu 
    530                 535                 540                 


Phe Arg Leu Leu Asp Glu Gly Ile Val Ser Pro Met Pro Ser Asp Pro 
545                 550                 555                 560 


Lys Lys Glu Arg Val Glu Asn Arg Asn Leu Cys Thr Val Ser Pro Thr 
                565                 570                 575     


Ala Leu Glu Ala Phe Arg Arg Leu Leu Asn Phe Asp Leu Ala Ile Gln 
            580                 585                 590         


Lys Glu Ala Val Arg Thr Ala Leu Glu Gln Ala Lys Ala Ser Glu Phe 
        595                 600                 605             


Val Glu Glu Gly Lys Leu Arg Gly Leu Val Ser Glu Leu Ala Gly Thr 
    610                 615                 620                 


Glu Asp Met Pro Ala Leu His Ile Pro Arg Phe Ser Ala Val Met Asp 
625                 630                 635                 640 


Lys Val Arg Arg Leu Ala Asp Asn Arg Asp Val Gly Leu Asp Pro Ile 
                645                 650                 655     


Leu Ser Thr Leu Gln Arg Ser Leu Pro Pro Thr Asp Lys Gln Ala Glu 
            660                 665                 670         


Ser Asp Ala Ala Arg Cys Arg Tyr Arg Leu Leu Leu Glu Leu Tyr Lys 
        675                 680                 685             


Ser Gly Phe Arg Ser Trp Phe Ser Gly Ile Gln Ser Asn Glu Glu Asn 
    690                 695                 700                 


Asn Arg Glu Ile Cys His Trp Ala Val Lys Gln Val Gly Arg Ala Lys 
705                 710                 715                 720 


Asp Ala Arg Lys Ser Glu Tyr Asp Lys Lys Thr Lys Arg His Tyr Arg 
                725                 730                 735     


Ser Pro Asn Ser Leu Ile Asp Asp Leu Gly Leu Asp Lys Phe Asp Asp 
            740                 745                 750         


Leu Thr Asp Leu Leu Glu Ala Leu Ala Ser Gln Ser Thr Arg Glu His 
        755                 760                 765             


Asp Gln Asn Leu Lys Tyr Val Pro Asp Ala Arg Val Gln Ser Gln Met 
    770                 775                 780                 


Ser Asn Arg Ile Glu Glu Phe Arg Gln Glu Leu Phe Ala His Ile Phe 
785                 790                 795                 800 


Thr Lys Tyr Leu Asp Thr His Asp Phe Gly Trp Ile Gly Ala Ile Glu 
                805                 810                 815     


Val Arg Arg Glu Ala Cys Asp Leu Ala Asp Val Val Ser Ala Phe Glu 
            820                 825                 830         


Val Arg Asp Gln Lys Phe Asp Ala Asp Trp His Ser Gln Phe Tyr Ala 
        835                 840                 845             


Trp Leu Tyr Met Val Pro Pro Ile Glu Ala Ser Arg Leu Arg His Gln 
    850                 855                 860                 


Met Arg Lys Ser Ala Val Met Asp Asp Lys Trp Ser Thr Thr Leu Glu 
865                 870                 875                 880 


Leu Thr Ser Gly Asp Arg Lys Thr Arg Asp Asp His Ala Gln Asp Val 
                885                 890                 895     


Leu Ala Asp Met Asp Arg Leu Phe Ser Leu Tyr Thr Lys Val Gln Ala 
            900                 905                 910         


Ala Gly Phe Asn Gly Gln Glu His Glu Ser Ala Leu Gly Ser Lys Ser 
        915                 920                 925             


Leu Phe Tyr Glu Asp Gly Asn Gln Phe Asp Glu Val Tyr Ser Pro Asp 
    930                 935                 940                 


Thr Glu Thr His Asn Lys Thr Phe Pro Gly Thr Arg Arg Gly Leu Arg 
945                 950                 955                 960 


Gln Leu Val Arg Tyr Ala His Leu Pro Ala Leu Glu Gly Val Phe Lys 
                965                 970                 975     


Lys His Arg Ile Thr Lys Ala Glu Val Glu Thr Phe Val Ala Leu Tyr 
            980                 985                 990         


Asp Glu Asn Arg Arg Asp Pro Gly  Ser Val Ala His Met  Leu Arg Arg 
        995                 1000                 1005             


Glu Lys  Leu Arg Thr Glu Ile  Leu Arg Ser Ile His  Asp Gly Pro 
    1010                 1015                 1020             


Lys Pro  Lys Asp Lys Asp Phe  Trp Pro Lys Leu Glu  Ala Lys Cys 
    1025                 1030                 1035             


Leu Glu  Tyr Arg Thr Val Ala  Thr Glu Thr Ala Ile  Tyr Asn Phe 
    1040                 1045                 1050             


Gln Ala  Asn Ala Ala Arg Leu  Asn Asp His Ala Arg  Leu His Gln 
    1055                 1060                 1065             


Ile Val  Met Arg Val Val Ala  Arg Leu Thr Asp Tyr  Ala Leu Ile 
    1070                 1075                 1080             


Trp Glu  Arg Asp Arg Leu Phe  Ala Phe Val Gly Met  Leu Tyr Arg 
    1085                 1090                 1095             


Gln Thr  Gly Gly Thr Gly Ile  Asn Pro Ala Met Arg  His Ala Glu 
    1100                 1105                 1110             


Lys Thr  Asn Ala Pro Pro Arg  Ile Gly Ile Leu Val  Ser Asp Ser 
    1115                 1120                 1125             


Ala Leu  Ala Lys Lys Leu Asn  Ser Asn Ser Ala Glu  Val Phe Ile 
    1130                 1135                 1140             


Pro Tyr  Leu Asp Thr Glu Thr  Gly Phe Asp Ala Pro  Arg Phe Asp 
    1145                 1150                 1155             


Asp Leu  Cys Thr Leu Leu Ser  His Glu His Ala Lys  Glu Phe Arg 
    1160                 1165                 1170             


Phe His  Phe Leu Glu Val Gly  Glu Glu Asn Ser Lys  Asp Glu Ala 
    1175                 1180                 1185             


Arg Arg  Leu Asn Glu Glu Thr  Met Gly His Arg Lys  Arg Pro Ala 
    1190                 1195                 1200             


Phe Lys  Arg Gly Thr Arg Arg  Gln Gly Ile Arg Asn  Asp Leu Ala 
    1205                 1210                 1215             


His His  Asn Val Leu Asp Leu  Ala Gly Gly Ala Gly  Pro Asn Leu 
    1220                 1225                 1230             


Thr Tyr  Val Val Asn Ala Val  Arg Ser Leu Leu Ser  Tyr Asp Arg 
    1235                 1240                 1245             


Lys Leu  Lys Asn Ala Val Pro  Lys Ser Ile Lys Arg  Ile Leu Gly 
    1250                 1255                 1260             


Glu Glu  Gly Leu Ile Ile Glu  Trp Gln Met Asn Tyr  Asp Arg Leu 
    1265                 1270                 1275             


Lys Lys  Pro Thr Val Tyr Pro  Asn Val Glu Thr His  Leu Thr Met 
    1280                 1285                 1290             


Val Pro  Pro Arg His Met Thr  Ala Pro Val Ser Phe  Thr Leu Pro 
    1295                 1300                 1305             


Arg Ala  Ser Val Arg Leu Ala  Ser Met Val Lys Ala  Val Phe Asp 
    1310                 1315                 1320             


Phe Gly  Ser Ser Gly Tyr Gly  Glu Glu Arg Met Ile  Gly Gly Arg 
    1325                 1330                 1335             


Thr Ala  Lys Gln Ala Val Tyr  Pro Asp Asp Phe Thr  Arg Arg Phe 
    1340                 1345                 1350             


Pro Gln  Thr Pro Met Gly Leu  Lys Gln Ala Thr Arg  Leu Val Phe 
    1355                 1360                 1365             


Ala Ser  Glu Asn Ser 
    1370             


<210>  516
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  516

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Gly Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asp 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  517
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  517

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Thr Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Asp Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val His Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1400                 1405                 1410         


<210>  518
<211>  955
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  518

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Asn Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Ile Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Ala Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Val Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Lys Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Ala Phe Ser Asp Gln Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Leu Lys Glu Leu Lys Glu Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn Tyr Thr Met Gln Gln Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Lys Lys Asp Glu Lys Phe Asn Asp Glu Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu 
945                 950                 955 


<210>  519
<211>  1402
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  519

Met Gly Asn Leu Phe Gly His Lys Arg Trp Tyr Glu Val Ser Asp Arg 
1               5                   10                  15      


Glu Asn Tyr Lys Ile Lys Arg Lys Val Lys Val Lys Arg Asn Tyr Asp 
            20                  25                  30          


Gly Asn Lys Tyr Ile Leu Asn Ile Asn Glu Asn Asn Asn Lys Glu Lys 
        35                  40                  45              


Ile Asp Asn Asn Glu Phe Ile Glu Glu Leu Val Asn Tyr Lys Lys Asn 
    50                  55                  60                  


Asn Asn Val Leu Arg Glu Phe Lys Arg Lys Phe His Ala Gly Asn Ile 
65                  70                  75                  80  


Leu Phe Lys Leu Lys Gly Asn Lys Arg Ser Ile Glu Asp Ser Asn Asp 
                85                  90                  95      


Phe Leu Lys Thr Glu Glu Val Val Leu Asp Lys Glu Ile Tyr Gly Gln 
            100                 105                 110         


Ser Glu Lys Leu Arg Asn Glu Lys Gly Ile Thr Lys Lys Asp Ile Leu 
        115                 120                 125             


Lys Glu Ile Asn Lys Gln Lys Ile Asp Asn Ser Val Lys Lys Ile Ser 
    130                 135                 140                 


Met Asn Thr Asn Ser Gly Lys Thr Ile Val Ile Asn Phe Ser Asp Lys 
145                 150                 155                 160 


Leu Lys Lys Asp Lys Asp Asp Tyr Gln Ile Thr Leu Asn Ile Ile Ser 
                165                 170                 175     


Glu Asp Glu Leu Glu Arg Lys Arg Lys Ile Tyr Asp Ile Phe Lys Met 
            180                 185                 190         


Ile Asn Met Asp Leu Tyr Gln Ile Ile Lys Glu Ile Ile Glu Asn Gln 
        195                 200                 205             


Val Gln Lys Val Phe Lys Asn Arg Tyr Tyr Glu Glu His Leu Arg Glu 
    210                 215                 220                 


Lys Leu Leu Lys Asp Asp Lys Met Asp Val Ile Leu Thr Asn Phe Met 
225                 230                 235                 240 


Lys Ile Arg Glu Lys Ile Glu Ser Asn Pro Glu Ile Met Gly Phe Val 
                245                 250                 255     


Lys Phe Tyr Leu Asn Val Gly Gly Asp Lys Lys Lys Ser Glu Asn Lys 
            260                 265                 270         


Lys Met Phe Val Glu Lys Ile Leu Asn Ile Asn Val Asp Leu Met Val 
        275                 280                 285             


Glu Asp Ile Val Asp Phe Ile Val Asn Glu Leu Lys Phe Trp Asn Ile 
    290                 295                 300                 


Thr Lys Arg Ile Glu Lys Leu Gln Glu Lys Thr Val Asn Arg Thr Asp 
305                 310                 315                 320 


Arg Asp Ile Lys Asn Thr Tyr Val Asn Thr Tyr Val Leu Leu Asp Lys 
                325                 330                 335     


His Glu Lys Phe Lys Lys Tyr Asn Arg Asn Lys Lys Asp Ile Ile Val 
            340                 345                 350         


Lys Ser Phe Ile Lys Asp Ile Arg Asp Asn Thr Met Lys Gln Lys Ile 
        355                 360                 365             


Asn Gln Ile Leu Ser Lys Phe Lys Ile Lys Glu Leu Lys Lys Asn Leu 
    370                 375                 380                 


Lys Glu Asn Thr Glu Asn Lys Asn Phe Asp Thr Glu Ile Phe Gly Ile 
385                 390                 395                 400 


Phe Lys Thr His Tyr Gln Asn Ile Phe Ser Ser Glu Lys Phe Glu Asn 
                405                 410                 415     


Lys Ser Asp Glu Glu Lys Glu Leu His Lys Ile Ile Tyr Arg Tyr Leu 
            420                 425                 430         


Lys Gly Arg Ile Glu Lys Ile Leu Ile Asn Arg Glu Lys Ile Arg Leu 
        435                 440                 445             


Asn Lys Ile Glu Ile Glu Lys Ile Leu Asn Glu Asn Val Leu Ser Lys 
    450                 455                 460                 


Lys Ile Leu Lys Arg Val Lys Gln Tyr Ser Leu Glu Tyr Ile Met Tyr 
465                 470                 475                 480 


Leu Gly Lys Leu Val His Asn Lys Pro Val Asp Asn Lys Pro Val Asp 
                485                 490                 495     


Asn Lys Ser Val Asp Asn Asn Asn Asn Ile Asp Met Thr Thr Val Asn 
            500                 505                 510         


Thr Asn Tyr Phe Ser Lys Leu His Ala Glu Glu Glu Leu Asp Leu Glu 
        515                 520                 525             


Leu Ile Thr Phe Phe Ala Ser Thr Asn Met Glu Leu Asn Lys Ile Phe 
    530                 535                 540                 


Glu Ile Asn Lys Gly Lys Asn Asp Phe Phe Gly Asp Ser Phe Lys Ile 
545                 550                 555                 560 


Asn Asp Thr Lys Val Leu Leu Lys Asn Asp Val Thr Ser Ser Lys Leu 
                565                 570                 575     


Tyr Ile Leu Lys Asn Leu Asn Phe Ile Asp Asn Glu Asn Lys Val Lys 
            580                 585                 590         


Lys Glu Glu Phe Ile Ser Lys Phe Ile Thr Ile Gly Val Asn Glu Arg 
        595                 600                 605             


Asn Arg Ile Leu His Ala Ser Asn Lys Arg Arg Val Pro Gln Gly Thr 
    610                 615                 620                 


Gln Asp Asp Tyr Lys Gly Thr Gln Asp Asp Tyr Asn Lys Val Ile Asn 
625                 630                 635                 640 


Ile Ile Gln Asn Leu Lys Ile Ser Asp Glu Glu Val Ser Lys Ala Leu 
                645                 650                 655     


Asn Leu Asp Val Val Phe Lys Asp Lys Lys Asn Ile Ile Thr Lys Ile 
            660                 665                 670         


Asn Asp Ile Lys Ile Ser Glu Glu Asn Ser Asn Asp Ile Lys Tyr Leu 
        675                 680                 685             


Pro Ser Phe Ser Lys Ile Leu Pro Glu Ile Leu Asn Leu Tyr Arg Asn 
    690                 695                 700                 


Asn Pro Arg Asn Glu Pro Phe Asp Thr Ile Glu Thr Glu Lys Ile Val 
705                 710                 715                 720 


Leu Asn Ala Leu Ile Tyr Val Asn Lys Glu Leu Tyr Lys Lys Leu Ile 
                725                 730                 735     


Leu Glu Asp Gly Ser Gln Glu Asn Arg Ser Lys Asn Ile Phe Leu Gln 
            740                 745                 750         


Glu Leu Lys Lys Thr Leu Gly Gly Thr Asp Glu Ile Asn Glu Asn Ile 
        755                 760                 765             


Ile Glu Asn Tyr Tyr Lys Asn Ala Gln Ile Ser Ala Ser Lys Gly Asn 
    770                 775                 780                 


Asn Lys Ala Ile Lys Lys Tyr Gln Lys Lys Val Ile Glu Cys Tyr Ile 
785                 790                 795                 800 


Gly Tyr Leu Arg Lys Asn Tyr Glu Glu Leu Phe Asp Phe Ser Asp Phe 
                805                 810                 815     


Lys Met Asn Ile Gln Glu Ile Lys Lys Gln Ile Lys Asp Ile Asn Asp 
            820                 825                 830         


Asn Lys Thr Tyr Glu Arg Ile Thr Ile Lys Thr Ile Asp Arg Thr Ile 
        835                 840                 845             


Val Ile Asn Asp Asp Phe Glu Tyr Ile Ile Ser Ile Phe Ala Leu Leu 
    850                 855                 860                 


Asn Ser Asn Ala Val Ile Asn Lys Ile Arg Asn Arg Phe Phe Ala Thr 
865                 870                 875                 880 


Ser Val Trp Leu Asn Ile Ser Lys Tyr Gln Asn Ile Ile Asn Ile Leu 
                885                 890                 895     


Asp Glu Ile Met Gln Ile Asn Ile Leu Lys Ser Glu Tyr Ile Thr Asp 
            900                 905                 910         


Asn Trp Lys Glu Asn Leu Glu Glu Phe Ile Arg Lys Ile Lys Asn Lys 
        915                 920                 925             


Glu Ile Glu Leu His Gln Ser Lys Lys Glu Phe Phe Asp Asn Asn Tyr 
    930                 935                 940                 


Lys Glu Ile Lys Asn Asp Ile Val Asn Glu Phe Gln Asp Asn Glu Glu 
945                 950                 955                 960 


Ile Lys Lys Ile Phe Asp Asn Asn Leu Lys Glu Ile Thr Glu Phe Arg 
                965                 970                 975     


Asn Asn Gly Ala Met Tyr Phe Lys Asn Leu Lys Glu Leu Ser Gln Ile 
            980                 985                 990         


Glu Arg Glu Phe Ile Leu Asp Asn  Lys Lys Leu Phe Glu  Asp Lys Ile 
        995                 1000                 1005             


Asp Glu  Ile Ile Ile Lys Lys  Gln Lys Glu Val Lys  Glu Glu Ile 
    1010                 1015                 1020             


Leu Ala  Lys Lys Ile Phe Asn  Ser Glu Phe Leu Glu  Lys Tyr Lys 
    1025                 1030                 1035             


Glu Glu  Ile Asp Asn Leu Val  Glu Ser Thr Glu Ser  Lys Asn Glu 
    1040                 1045                 1050             


Asn Lys  Phe Glu Lys Ile Tyr  His Pro Glu Glu His  Lys Asn Glu 
    1055                 1060                 1065             


Leu Tyr  Ile Tyr Lys Lys Asn  Leu Phe Leu Asn Ile  Gly Asn Pro 
    1070                 1075                 1080             


Asn Phe  Asp Lys Ile Tyr Glu  Ile Ile Ser Lys Asp  Ile Lys Asn 
    1085                 1090                 1095             


Ala Asn  Thr Glu Ile Leu Phe  Asp Asn Asp Ile Arg  Lys Asn Lys 
    1100                 1105                 1110             


Ile Ser  Glu Ile Asp Ala Ile  Leu Lys Asn Leu Asn  Asp Lys Leu 
    1115                 1120                 1125             


Asn Gly  Tyr Ser Asn Asp Tyr  Lys Ala Lys Tyr Val  Asn Lys Leu 
    1130                 1135                 1140             


Lys Glu  Asn Asp Asp Phe Phe  Ala Lys Asn Ile Gln  Asn Glu Asn 
    1145                 1150                 1155             


Tyr Ser  Ser Phe Gly Glu Phe  Glu Lys Asp Tyr Asn  Lys Val Ser 
    1160                 1165                 1170             


Glu Tyr  Lys Lys Ile Arg Asp  Leu Val Glu Phe Asn  Tyr Leu Asn 
    1175                 1180                 1185             


Lys Ile  Glu Ser Tyr Leu Ile  Asp Ile Asn Trp Lys  Leu Ala Ile 
    1190                 1195                 1200             


Gln Met  Ala Arg Phe Glu Arg  Asp Met His Tyr Ile  Val Asn Gly 
    1205                 1210                 1215             


Leu Arg  Glu Leu Gly Ile Ile  Lys Leu Ser Gly Tyr  Asn Thr Gly 
    1220                 1225                 1230             


Ile Ser  Arg Ala Tyr Pro Lys  Arg Asn Gly Ser Asp  Gly Phe Tyr 
    1235                 1240                 1245             


Thr Thr  Thr Ala Tyr Tyr Lys  Phe Leu Asp Glu Glu  Ser Tyr Lys 
    1250                 1255                 1260             


Lys Phe  Glu Lys Ile Cys Tyr  Gly Phe Gly Ile Asp  Leu Ser Glu 
    1265                 1270                 1275             


Asn Ser  Glu Ile Asn Lys Pro  Glu Asn Glu Ser Ile  Arg Asn Tyr 
    1280                 1285                 1290             


Ile Ser  His Phe Tyr Ile Val  Arg Asn Pro Phe Val  Asp Tyr Ser 
    1295                 1300                 1305             


Ile Ala  Glu Gln Ile Asp Arg  Val Ser Asn Leu Leu  Ser Tyr Ser 
    1310                 1315                 1320             


Thr Arg  Tyr Asn Asn Ser Thr  Tyr Ala Ser Val Phe  Glu Val Phe 
    1325                 1330                 1335             


Lys Lys  Asp Val Asp Leu Asn  Tyr Asp Glu Leu Lys  Lys Lys Phe 
    1340                 1345                 1350             


Lys Leu  Ile Gly Asn Asn Asn  Ile Leu Glu Arg Leu  Met Arg Pro 
    1355                 1360                 1365             


Lys Lys  Val Ser Val Leu Glu  Leu Glu Ser Tyr Asn  Ser Gly Tyr 
    1370                 1375                 1380             


Ile Lys  Asn Leu Ile Ile Glu  Leu Leu Thr Lys Ile  Glu Asn Thr 
    1385                 1390                 1395             


Asn Asp  Thr Leu 
    1400         


<210>  520
<211>  1262
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  520

Met Arg Gly Gly His Met Lys Ile Thr Lys Ile Asp Gly Ile Ser His 
1               5                   10                  15      


Tyr Lys Glu Lys Glu Lys Gly Val Leu Lys Ala Lys Asp Val Leu Asn 
            20                  25                  30          


Glu Glu Ile Lys Glu Ile Val Lys Lys Arg Tyr Asp Ala Thr Ile Glu 
        35                  40                  45              


Ser Lys Ile Tyr Lys Glu Phe Ile Lys Leu Arg Lys Asn Arg Ile Glu 
    50                  55                  60                  


Gln Asn Asn Glu Lys Ser Val Leu Glu Leu Ile Lys Ser Asn Ile Asp 
65                  70                  75                  80  


Lys Asn Glu Lys Glu Ile Lys Thr Leu Leu Trp Asn Lys Phe Lys Ile 
                85                  90                  95      


Lys Glu Lys Asn Lys Lys Tyr Asp Lys Tyr Ile Leu Asp Glu Ile Lys 
            100                 105                 110         


Leu Asp Asn Asp Ile Lys Ile Tyr Glu Ser Ala Glu Ser Leu Tyr Phe 
        115                 120                 125             


Phe Ile Lys Glu Val Tyr Leu Gly Gln Asn Asn Lys Lys Trp Asn Ile 
    130                 135                 140                 


Ser Lys Ile Asp Leu Glu Lys Ile Met Glu Lys Asp Asn Asn Leu Ile 
145                 150                 155                 160 


Met Leu Gly Tyr Lys Leu Lys Lys Asn Ile Lys Glu Asp Glu Tyr Pro 
                165                 170                 175     


Tyr Leu Tyr Lys Asn Lys Asn Lys Gln Lys Ser Thr Pro Leu Tyr Thr 
            180                 185                 190         


Leu Leu Lys Lys Leu Ile Glu Lys Asn Lys Asn Ser Asn Gln Asn Ile 
        195                 200                 205             


Arg Glu Ser Glu Glu Tyr Glu Lys Ile Gln Lys Lys Phe Lys Glu Tyr 
    210                 215                 220                 


Lys Asn Ile Lys Ile Asn Leu Leu Val Lys Ser Ile Leu Asn Asn Lys 
225                 230                 235                 240 


Val Asn Ile Lys Tyr Asn Thr Ser Asn Asn Asn Ile Glu Glu Ser Asn 
                245                 250                 255     


Ser Lys Arg Glu Lys Glu Ile Ile Glu Phe Phe Lys Lys Met Ile Glu 
            260                 265                 270         


Glu Lys Asn Lys Ser Ile Leu Lys Asp Lys Leu Lys Leu Phe Arg Leu 
        275                 280                 285             


Glu Val Phe Phe Asp Glu Glu Phe Leu Glu Glu Ile Lys Lys Leu Leu 
    290                 295                 300                 


Asp Ser Gly Asp Ser Asp Lys Ser Asp Asn Lys Lys Ile Ala Glu Leu 
305                 310                 315                 320 


Arg Gly Lys Ile Phe Ser Arg Ile Arg Glu Lys Ile Lys Glu Asp Lys 
                325                 330                 335     


Asn Arg Tyr Ile Leu Lys Asn Ile Tyr Phe Leu Glu Leu Lys Lys Tyr 
            340                 345                 350         


Ile Glu Asn Asn Leu Ser His Lys Lys Glu Asn Asn Lys Asn Asn Ser 
        355                 360                 365             


Asn Ile Gly Glu Glu Lys Ser Lys Lys Leu Tyr Leu Lys Phe Leu Lys 
    370                 375                 380                 


Lys Val Leu Phe Ile Asp Asp Asn Asn Arg Ile Ser Ile Glu Lys Leu 
385                 390                 395                 400 


Lys Ser Arg Ile Asp Asp Asn Phe Lys Asn Leu Leu Ile Gln His Val 
                405                 410                 415     


Ile Glu Tyr Gly Lys Ile Lys Tyr Tyr Val Glu Asn Asp Asp Tyr Ile 
            420                 425                 430         


Lys Asn Ile Val Lys Asn Gly Glu Leu Lys Leu Glu Thr Glu Asn Leu 
        435                 440                 445             


Glu Tyr Ile Arg Ile Arg Glu Thr Leu Ile Arg Lys Met Ala Val Leu 
    450                 455                 460                 


Val Ser Phe Ala Ala Asn Ser Phe Tyr Asn Leu Phe Glu Asn Ile Thr 
465                 470                 475                 480 


Ser Asp Ile Leu Thr Ala Asn Ile Asn Leu Asp Ser Gly Val Ile Lys 
                485                 490                 495     


Ile Gly Asn Asn Arg Leu Lys Glu Lys Phe Leu Asn Tyr Phe Phe Tyr 
            500                 505                 510         


Ser Glu Glu Ile Leu Asp Lys Glu Asp Phe Leu Lys Ala Leu Lys Asp 
        515                 520                 525             


Ser Ile Tyr Asn Val Arg Asn Gly Val Asn His Phe Asp Lys Met Ile 
    530                 535                 540                 


Leu Gly Lys Tyr Asn Asn Gly Leu Asp Leu Lys Asp Ser Asp Thr Ile 
545                 550                 555                 560 


Lys Asp Tyr Phe Asn Phe Lys Lys Lys Glu Ile Gln Gln Asp Leu Arg 
                565                 570                 575     


Asp Arg Phe Ile Ser Asn Asn Leu Gln Tyr Tyr Tyr Thr Glu Asn Glu 
            580                 585                 590         


Ile Lys Lys Tyr Phe Glu Lys Tyr Lys Phe Glu Ile Leu Lys Thr Lys 
        595                 600                 605             


Ala Ser Phe Ala Pro Asn Phe Lys Arg Ile Leu Arg Lys Gly Glu Asn 
    610                 615                 620                 


Leu Ser Ile Ser Glu Ile Ser Asp Ile Tyr Asp Phe Phe Lys Arg Tyr 
625                 630                 635                 640 


Ser Glu Asn Ser Asp Lys Ser Ser Glu Tyr Asn Glu Phe Thr Lys Thr 
                645                 650                 655     


Arg Asn Phe Leu Leu Lys Glu Leu Tyr Tyr Asn Asn Phe Tyr Arg Glu 
            660                 665                 670         


Phe Leu Ser Asp Gly Thr Lys Phe Glu Glu Ala Val Lys Lys Val Lys 
        675                 680                 685             


Asn Asn Lys Lys Ser Arg Ile Ile Ser Asn Lys Lys Ser Ala Gly Lys 
    690                 695                 700                 


Ser Tyr Asp Val Ile Glu Asp Tyr Asn Ser Ser Asp Asp Val Leu Glu 
705                 710                 715                 720 


Tyr Ile Ser Arg Ile His Lys Ser Glu Met Glu Arg Ile Glu Ile Asn 
                725                 730                 735     


Thr Glu Lys Asn Arg Lys Asp Thr Ser Lys Tyr Ile Arg Asp Phe Ile 
            740                 745                 750         


Glu Glu Val Phe Leu Glu Gly Phe Ile Lys Tyr Leu Asp Asn Asn Asn 
        755                 760                 765             


Leu Asn Phe Leu Lys Asn Arg Asn Lys Val Asp Lys Glu Arg Lys Glu 
    770                 775                 780                 


Ile Ile Arg Asn Leu Asn Ile Lys Ile Glu Gly Leu Asp Ile Leu Asn 
785                 790                 795                 800 


Gln Asn Asp Ser Glu Ile Leu Asn Leu Tyr Leu Phe Phe Asn Met Ile 
                805                 810                 815     


Asp Asn Lys Arg Ile Ser Glu Phe Arg Asn Glu Met Ile Lys Tyr Lys 
            820                 825                 830         


Gln Phe Leu Thr Lys Arg Gln Asn Ile Lys Ser Lys Phe Leu Glu Ile 
        835                 840                 845             


Asp Ile Glu Lys Ile Glu Ala Ile Ile Glu Phe Val Ile Ile Thr Arg 
    850                 855                 860                 


Gly Lys Leu Glu Ile Leu Glu Gly Glu Thr Lys Glu Gln Lys Lys Asp 
865                 870                 875                 880 


Asn Met Asn Ala Leu Phe Asn Lys Phe Tyr Ser Ser Glu Ser Glu Tyr 
                885                 890                 895     


Asp Glu Ser Leu Lys Lys Phe Ile Glu Glu Thr Val Leu Asn Asp Lys 
            900                 905                 910         


Lys Asn Thr Pro Phe Tyr Ser Thr Asp Gly Lys Thr Pro Ile Val His 
        915                 920                 925             


Ser Asn Leu Glu Lys Met Arg Lys Tyr Gly Thr Glu Asn Phe Leu Ser 
    930                 935                 940                 


Lys Val Leu Lys Asp Glu Lys Tyr Thr Leu Glu Asn Met Lys Ile Lys 
945                 950                 955                 960 


Glu Lys Phe Glu Thr Glu Ala Asn Asp Lys Phe Lys Glu Gln Lys Ile 
                965                 970                 975     


Leu Glu Lys Val Asp Lys Ile Lys Gly Asn Glu Lys His Lys Lys Leu 
            980                 985                 990         


Ile Glu Tyr Tyr Asn Asp Cys Arg  Cys Tyr Leu His Lys  Glu Trp Ile 
        995                 1000                 1005             


Glu Asn  Lys Lys Asn Lys Glu  Glu Phe Glu Tyr Lys  Glu Ile Tyr 
    1010                 1015                 1020             


Glu Lys  Ile Ile Glu Glu Ile  Arg Lys Tyr Asn Tyr  Leu Glu Asn 
    1025                 1030                 1035             


Lys Glu  Lys Leu Gln Asn Val  Tyr Leu Leu His Glu  Ile Thr Ser 
    1040                 1045                 1050             


Asp Leu  Met Ala Arg Asn Val  Ala Phe Ile Asn Lys  Trp Glu Arg 
    1055                 1060                 1065             


Asp Phe  Lys Phe Leu Ser Ile  Ala Ile Lys Glu Asn  Leu Lys Asp 
    1070                 1075                 1080             


Ser Asn  Asp Ile Gln Lys Ile  Lys Glu Phe Leu Ala  Pro Ser Leu 
    1085                 1090                 1095             


Asp Thr  Thr Ser Asp Glu Glu  His Phe Asn Val Lys  Asn Tyr Ala 
    1100                 1105                 1110             


Ser Lys  Leu Lys Asn Ile Gln  Gly Leu His Asn Asn  Ile Ile Ser 
    1115                 1120                 1125             


Leu Ile  Phe Ile Lys Asn Leu  Asp Gly Trp Ser Asn  Lys Ile Asp 
    1130                 1135                 1140             


Asn Phe  Lys Trp Leu Gly Phe  Arg Asn Tyr Ile Ser  His Phe Asn 
    1145                 1150                 1155             


His Ile  Asn Gly Glu Asn Ser  Lys Glu Ser Phe Ile  Asn Gln Leu 
    1160                 1165                 1170             


Asn Arg  Leu Ile Leu Leu Phe  Ser Tyr Asp Lys Lys  Val Gln Asn 
    1175                 1180                 1185             


His Ile  Thr Lys Ser Ile Lys  Thr Ile Leu Glu Lys  Tyr Asn Ile 
    1190                 1195                 1200             


Asp Ile  Glu Phe Lys Ile Ser  Asp Asp Ser Lys Asn  Phe Phe Glu 
    1205                 1210                 1215             


Tyr Gln  Ile Ser Asn Ile Asn  Ser Lys Lys Gly Lys  Met Leu Gly 
    1220                 1225                 1230             


Lys Glu  Asn Tyr Phe Glu Leu  Leu Asp Glu Glu Phe  Val Gln Asn 
    1235                 1240                 1245             


Val Lys  Lys Met Leu Glu Tyr  Glu Asp Gln Arg Thr  Gly Gly 
    1250                 1255                 1260         


<210>  521
<211>  1389
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  521

Met Gly Asn Leu Phe Gly His Lys Arg Trp Tyr Glu Val Ser Asp Arg 
1               5                   10                  15      


Gly Asp Asn Lys Ile Lys Arg Lys Val Lys Val Lys Arg Asn Tyr Asp 
            20                  25                  30          


Gly Asn Lys Tyr Ile Leu Asn Ile Asn Glu Asn Asn Asn Lys Glu Lys 
        35                  40                  45              


Ile Asp Asn Asn Lys Phe Ile Gly Glu Phe Val Asn Tyr Lys Lys Asn 
    50                  55                  60                  


Asn Asn Val Leu Lys Glu Phe Lys Arg Lys Phe His Ala Gly Asn Ile 
65                  70                  75                  80  


Leu Phe Lys Leu Lys Gly Lys Val Lys Asp Lys Lys Asn Ile Lys Arg 
                85                  90                  95      


Ile Lys Asn Asn Asp Asp Phe Leu Glu Thr Glu Lys Val Val Leu Tyr 
            100                 105                 110         


Ile Glu Val Tyr Gly Lys Ser Glu Lys Leu Lys Ala Leu Gly Ile Thr 
        115                 120                 125             


Lys Lys Lys Ile Ile Asp Glu Ala Ile Arg Gln Gly Ile Thr Lys Asp 
    130                 135                 140                 


Asp Lys Lys Ile Glu Ile Lys Arg Gln Glu Asn Glu Glu Glu Ile Glu 
145                 150                 155                 160 


Ile Asp Ile Arg Asp Glu Tyr Thr Asn Lys Thr Leu Asn Asp Tyr Ser 
                165                 170                 175     


Ile Ile Leu Arg Ile Ile Glu Asn Asp Glu Leu Glu Thr Lys Lys Ser 
            180                 185                 190         


Ile Tyr Glu Ile Phe Lys Asn Ile Asn Met Ser Leu Tyr Lys Ile Ile 
        195                 200                 205             


Glu Lys Ile Ile Glu Asn Glu Thr Glu Lys Val Phe Glu Asn Arg Tyr 
    210                 215                 220                 


Tyr Glu Glu His Leu Arg Glu Lys Leu Leu Lys Asp Asn Lys Ile Asp 
225                 230                 235                 240 


Val Ile Leu Thr Asn Phe Met Glu Ile Arg Glu Lys Ile Lys Ser Asn 
                245                 250                 255     


Leu Glu Ile Met Gly Phe Val Lys Phe Tyr Leu Asn Val Ser Gly Asp 
            260                 265                 270         


Lys Lys Lys Ser Glu Asn Lys Lys Ile Phe Val Glu Lys Ile Leu Asn 
        275                 280                 285             


Thr Asn Ile Asp Leu Thr Val Glu Asp Ile Val Asp Phe Ile Val Lys 
    290                 295                 300                 


Glu Leu Lys Phe Trp Asn Ile Thr Lys Arg Ile Glu Lys Val Lys Lys 
305                 310                 315                 320 


Phe Asn Asn Glu Phe Leu Glu Asn Arg Arg Asn Arg Thr Tyr Ile Lys 
                325                 330                 335     


Ser Tyr Val Leu Leu Asp Lys His Glu Lys Phe Lys Ile Glu Arg Glu 
            340                 345                 350         


Asn Lys Lys Asp Lys Ile Val Lys Phe Phe Val Glu Asn Ile Lys Asn 
        355                 360                 365             


Asn Ser Ile Lys Glu Lys Ile Glu Lys Ile Leu Ala Glu Phe Lys Ile 
    370                 375                 380                 


Asn Glu Leu Ile Lys Lys Leu Glu Lys Glu Leu Lys Lys Gly Asn Cys 
385                 390                 395                 400 


Asp Thr Glu Ile Phe Gly Ile Phe Lys Lys His Tyr Lys Val Asn Phe 
                405                 410                 415     


Asp Ser Lys Lys Phe Ser Asn Lys Ser Asp Glu Glu Lys Glu Leu Tyr 
            420                 425                 430         


Lys Ile Ile Tyr Arg Tyr Leu Lys Gly Arg Ile Glu Lys Ile Leu Val 
        435                 440                 445             


Asn Glu Gln Lys Val Arg Leu Lys Lys Met Glu Lys Ile Glu Ile Glu 
    450                 455                 460                 


Lys Ile Leu Asn Glu Ser Ile Leu Ser Glu Lys Ile Leu Lys Arg Val 
465                 470                 475                 480 


Lys Gln Tyr Thr Leu Glu His Ile Met Tyr Leu Gly Lys Leu Arg His 
                485                 490                 495     


Asn Asp Ile Val Lys Met Thr Val Asn Thr Asn Asp Phe Ser Arg Leu 
            500                 505                 510         


His Ala Lys Glu Glu Leu Asp Leu Glu Leu Ile Thr Phe Phe Ala Ser 
        515                 520                 525             


Thr Asn Met Glu Leu Asn Lys Ile Phe Glu Ile Asn Lys Glu Lys Asn 
    530                 535                 540                 


Asp Phe Phe Gly Asp Ser Phe Lys Ile Asn Asp Thr Lys Val Leu Leu 
545                 550                 555                 560 


Lys Asn Glu Val Thr Ser Ser Lys Leu Tyr Ile Leu Lys Asn Leu Asn 
                565                 570                 575     


Phe Ile Asp Asn Glu Asn Lys Val Lys Lys Glu Glu Phe Ile Ser Lys 
            580                 585                 590         


Phe Ile Thr Ile Gly Val Asn Glu Arg Asn Arg Ile Leu His Ala Asn 
        595                 600                 605             


Ser Lys Glu Ile Ala Pro Lys Gly Lys Gln Asp Asn Tyr Asp Lys Val 
    610                 615                 620                 


Ile Asn Ile Phe Gln Asn Leu Lys Ile Ser Asp Glu Glu Val Ser Lys 
625                 630                 635                 640 


Ala Leu Asn Leu Asp Val Val Phe Lys Asn Lys Lys Asp Ile Ile Thr 
                645                 650                 655     


Lys Ile Asn Asp Ile Lys Ile Ser Glu Lys Asn Ser Asn Asp Ile Lys 
            660                 665                 670         


Tyr Leu Pro Ser Phe Ser Lys Val Leu Pro Glu Ile Leu Asn Leu Tyr 
        675                 680                 685             


Arg Asn Asn Pro Lys Asn Glu Pro Phe Asp Thr Ile Glu Thr Glu Lys 
    690                 695                 700                 


Ile Val Leu Asn Ala Leu Ile Tyr Val Asn Lys Glu Leu Tyr Lys Lys 
705                 710                 715                 720 


Leu Ile Leu Glu Asp Asp Leu Gln Glu Asn Asp Leu Gln Glu Asn Arg 
                725                 730                 735     


Ser Lys Asn Ile Phe Leu Gln Glu Leu Lys Lys Thr Leu Gly Asn Ile 
            740                 745                 750         


Asp Glu Ile Asp Glu Asn Ile Ile Glu Asn Tyr Tyr Lys Asn Ala Gln 
        755                 760                 765             


Ile Ser Ala Ser Lys Gly Asn Asn Lys Ala Ile Lys Lys Tyr Gln Lys 
    770                 775                 780                 


Lys Ile Ile Glu Cys Tyr Ile Glu Tyr Leu Arg Lys Asn Tyr Glu Lys 
785                 790                 795                 800 


Leu Phe Asp Phe Ser Asp Phe Lys Met Asn Ile Gln Glu Ile Lys Lys 
                805                 810                 815     


Gln Ile Lys Glu Ile Asn Asp Asn Lys Thr Tyr Lys Arg Ile Thr Ile 
            820                 825                 830         


Asn Thr Ser Asp Lys Ser Ile Ala Ile Asn Asn Asp Phe Glu Tyr Ile 
        835                 840                 845             


Ile Ser Ile Phe Ala Leu Leu Asn Ser Asn Ala Val Ile Asn Lys Ile 
    850                 855                 860                 


Arg Asn Arg Phe Phe Ala Thr Ser Val Trp Leu Asp Thr Ser Glu Tyr 
865                 870                 875                 880 


Gln Asn Ile Ile Asp Ile Leu Asp Glu Ile Met Gln Ile Asn Ile Leu 
                885                 890                 895     


Lys Ser Glu Tyr Ile Thr Gly Asn Trp Lys Glu Asn Leu Glu Glu Phe 
            900                 905                 910         


Ile Arg Lys Ile Lys Asn Lys Glu Ile Glu Leu Asp Gln Ser Lys Lys 
        915                 920                 925             


Glu Phe Phe Asp Asn Asn Tyr Lys Glu Ile Lys Asn Asp Ile Val Asn 
    930                 935                 940                 


Gly Phe Gln Asp Asn Glu Glu Ile Lys Lys Ile Phe Asp Asn Asp Leu 
945                 950                 955                 960 


Lys Glu Ile Thr Glu Phe Arg Asn Asn Gly Ala Met Tyr Phe Lys Asn 
                965                 970                 975     


Leu Lys Glu Leu Ser Gln Ile Glu Arg Glu Phe Ile Leu Asp Asn Lys 
            980                 985                 990         


Lys Leu Phe Glu Asp Lys Ile Asp  Glu Ile Ile Val Lys  Lys Gln Lys 
        995                 1000                 1005             


Glu Ile  Lys Glu Glu Ile Leu  Ser Lys Lys Ile Phe  Asn Ser Glu 
    1010                 1015                 1020             


Phe Leu  Glu Lys Tyr Lys Glu  Ile Ile Asp Asn Leu  Thr Lys Asn 
    1025                 1030                 1035             


Glu Asn  Lys Phe Glu Lys Ile  Tyr Tyr Pro Lys Lys  Asn Lys Asn 
    1040                 1045                 1050             


Glu Leu  Tyr Ile Tyr Lys Lys  Asn Leu Phe Leu Asn  Ile Gly Asn 
    1055                 1060                 1065             


Pro Asn  Phe Asp Lys Ile Tyr  Gly Leu Ile Ser Lys  Asp Ile Lys 
    1070                 1075                 1080             


Asn Val  Asp Thr Lys Ile Leu  Phe Asp Asp Asp Ile  Arg Lys Asn 
    1085                 1090                 1095             


Lys Ile  Ser Glu Ile Asp Ala  Ile Leu Lys Asn Leu  Asn Asp Lys 
    1100                 1105                 1110             


Leu Asn  Gly Tyr Ser Asn Asp  Tyr Lys Ala Lys Tyr  Val Asn Lys 
    1115                 1120                 1125             


Leu Lys  Glu Asn Tyr Asp Phe  Phe Ala Lys Asn Ile  Gln Asn Glu 
    1130                 1135                 1140             


Asn Tyr  Ser Ser Phe Gly Glu  Phe Glu Lys Asp Tyr  Asn Lys Val 
    1145                 1150                 1155             


Ser Glu  Tyr Lys Lys Ile Arg  Asp Leu Val Glu Phe  Asn Tyr Leu 
    1160                 1165                 1170             


Asn Lys  Ile Glu Ser Tyr Leu  Ile Asp Ile Asn Trp  Lys Leu Ala 
    1175                 1180                 1185             


Ile Gln  Met Ala Arg Phe Glu  Arg Asp Met His Tyr  Ile Val Asn 
    1190                 1195                 1200             


Gly Leu  Arg Glu Leu Gly Ile  Ile Lys Leu Ser Gly  Tyr Asn Thr 
    1205                 1210                 1215             


Gly Ile  Ser Arg Ala Tyr Pro  Lys Arg Asn Gly Ser  Asp Gly Phe 
    1220                 1225                 1230             


Tyr Lys  Thr Thr Ala Tyr Tyr  Lys Phe Phe Asp Glu  Glu Ser Tyr 
    1235                 1240                 1245             


Lys Lys  Phe Glu Lys Ile Cys  Tyr Gly Phe Gly Ile  Asp Leu Ser 
    1250                 1255                 1260             


Glu Asn  Ser Glu Ile Asn Lys  Pro Glu Asn Glu Ser  Ile Arg Asn 
    1265                 1270                 1275             


Tyr Ile  Ser His Phe Tyr Ile  Val Arg Asn Pro Phe  Val Asp Tyr 
    1280                 1285                 1290             


Ser Ile  Ala Gln Gln Ile Asp  Arg Val Ser Asn Leu  Leu Ser Tyr 
    1295                 1300                 1305             


Ser Thr  Arg Tyr Asn Asn Ser  Thr Tyr Ala Ser Val  Phe Glu Val 
    1310                 1315                 1320             


Phe Lys  Lys Asp Val Asp Leu  Asp Tyr Asp Glu Leu  Lys Lys Lys 
    1325                 1330                 1335             


Phe Lys  Leu Ile Gly Asn Asn  Asp Ile Leu Glu Arg  Leu Met Lys 
    1340                 1345                 1350             


Pro Lys  Lys Val Ser Val Leu  Glu Leu Glu Ser Tyr  Asn Ser Asp 
    1355                 1360                 1365             


Tyr Ile  Lys Asn Leu Ile Ile  Glu Leu Leu Thr Lys  Val Glu Asn 
    1370                 1375                 1380             


Lys Asp  Glu Ile Ser Ser 
    1385                 


<210>  522
<211>  1315
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  522

Met Ala Glu Thr Leu Thr Phe Thr Asn Leu Tyr Asp Ile Leu Thr Leu 
1               5                   10                  15      


Ile Asp Ser Gly Leu Asn Leu His Ile Asn Leu Gly Val Ile Ile Met 
            20                  25                  30          


Lys Leu Thr Arg Arg Arg Ile Ser Gly Asn Ser Val Asp Gln Lys Ile 
        35                  40                  45              


Thr Ala Ala Phe Tyr Arg Asp Met Ser Gln Gly Leu Leu Tyr Tyr Asp 
    50                  55                  60                  


Ser Glu Asp Asn Asp Cys Thr Asp Lys Val Ile Glu Ser Met Asp Phe 
65                  70                  75                  80  


Glu Arg Ser Trp Arg Gly Arg Ile Leu Lys Asn Gly Glu Asp Asp Lys 
                85                  90                  95      


Asn Pro Phe Tyr Met Phe Val Lys Gly Leu Val Gly Ser Asn Asp Lys 
            100                 105                 110         


Ile Val Cys Glu Pro Ile Asp Val Asp Ser Asp Pro Asp Asn Leu Asp 
        115                 120                 125             


Ile Leu Ile Asn Lys Asn Leu Thr Gly Phe Gly Arg Asn Leu Lys Ala 
    130                 135                 140                 


Pro Asp Ser Asn Asp Thr Leu Glu Asn Leu Ile Arg Lys Ile Gln Ala 
145                 150                 155                 160 


Gly Ile Pro Glu Glu Glu Val Leu Pro Glu Leu Lys Lys Ile Lys Glu 
                165                 170                 175     


Met Ile Gln Lys Asp Ile Val Asn Arg Lys Glu Gln Leu Leu Lys Ser 
            180                 185                 190         


Ile Lys Asn Asn Arg Ile Pro Phe Ser Leu Glu Gly Ser Lys Leu Val 
        195                 200                 205             


Pro Ser Thr Lys Lys Met Lys Trp Leu Phe Lys Leu Ile Asp Val Pro 
    210                 215                 220                 


Asn Lys Thr Phe Asn Glu Lys Met Leu Glu Lys Tyr Trp Glu Ile Tyr 
225                 230                 235                 240 


Asp Tyr Asp Lys Leu Glu Ala Asn Ile Thr Asn Arg Leu Asp Lys Thr 
                245                 250                 255     


Asp Lys Asn Ala Arg Ser Ile Ser Arg Ala Val Ser Asp Glu Leu Arg 
            260                 265                 270         


Glu Tyr His Lys Tyr Leu Arg Thr Asn Tyr Asn Arg Phe Val Ser Gly 
        275                 280                 285             


Asp Arg Pro Ala Ala Gly Leu Asp Asn Gly Gly Ser Ala Lys Tyr Asn 
    290                 295                 300                 


Pro Asp Lys Glu Glu Phe Leu Leu Phe Leu Lys Glu Val Glu Gln Tyr 
305                 310                 315                 320 


Phe Lys Lys Tyr Phe Pro Val Lys Ser Lys His Ser Asn Lys Ser Lys 
                325                 330                 335     


Asp Lys Ser Leu Val Asp Lys Tyr Lys Asn Tyr Cys Ser Tyr Lys Val 
            340                 345                 350         


Val Lys Lys Glu Val Asn Arg Ser Ile Ile Asn Gln Leu Val Ala Gly 
        355                 360                 365             


Leu Ile Gln Gln Gly Lys Leu Leu Tyr Tyr Phe Tyr Tyr Asn Asp Thr 
    370                 375                 380                 


Trp Gln Glu Asp Phe Leu Asn Ser Tyr Gly Leu Ser Tyr Ile Gln Val 
385                 390                 395                 400 


Glu Glu Ala Phe Lys Lys Ser Val Met Thr Ser Leu Ser Trp Gly Ile 
                405                 410                 415     


Asn Arg Leu Thr Ser Phe Phe Ile Asp Asp Ser Asn Thr Val Lys Phe 
            420                 425                 430         


Asp Asp Ile Thr Thr Lys Arg Ala Lys Glu Ala Ile Glu Ser Asn Tyr 
        435                 440                 445             


Phe Asn Lys Leu Arg Thr Cys Ser Arg Met Gln Asp His Phe Lys Glu 
    450                 455                 460                 


Lys Leu Ala Phe Phe Tyr Pro Val Tyr Val Lys Asp Lys Lys Asp Arg 
465                 470                 475                 480 


Pro Asp Asp Ile Glu Lys Leu Ile Val Leu Val Lys Asn Ala Ile Glu 
                485                 490                 495     


Ser Val Ser Tyr Leu Arg Asn Arg Ile Phe His Phe Lys Lys Ser Ser 
            500                 505                 510         


Leu Leu Glu Leu Leu Lys Glu Leu Asp Asp Lys Asn Ser Gly Gln Asp 
        515                 520                 525             


Lys Ile Asp Tyr Ser Val Ala Ala Glu Phe Ile Lys Arg Asp Ile Glu 
    530                 535                 540                 


Asn Leu Tyr Asp Val Phe Arg Glu Gln Ile Arg Ser Leu Gly Ile Ala 
545                 550                 555                 560 


Glu Tyr Tyr Lys Ala Asp Met Ile Ser Asp Cys Phe Lys Thr Cys Gly 
                565                 570                 575     


Leu Glu Phe Ala Leu Tyr Ser Pro Lys Asn Ser Leu Met Pro Ala Phe 
            580                 585                 590         


Lys Asn Val Tyr Lys Arg Gly Ala Asn Leu Asn Lys Ala Tyr Ile Arg 
        595                 600                 605             


Asp Lys Gly Pro Lys Glu Thr Gly Asp Gln Gly Gln Asn Ser Tyr Lys 
    610                 615                 620                 


Ala Leu Glu Glu Tyr Arg Glu Leu Thr Trp Tyr Ile Glu Val Lys Asn 
625                 630                 635                 640 


Asn Asp Gln Ser Tyr Asn Ala Tyr Lys Asn Leu Leu Gln Leu Ile Tyr 
                645                 650                 655     


Tyr His Ala Phe Leu Pro Glu Val Arg Glu Asn Glu Ala Leu Ile Thr 
            660                 665                 670         


Asp Phe Ile Asn Arg Thr Lys Glu Trp Asn Arg Lys Glu Thr Glu Glu 
        675                 680                 685             


Arg Leu Asn Thr Lys Asn Asn Lys Lys His Lys Asn Phe Asp Glu Asn 
    690                 695                 700                 


Asp Asp Ile Thr Val Asn Thr Tyr Arg Tyr Glu Ser Ile Pro Asp Tyr 
705                 710                 715                 720 


Gln Gly Glu Ser Leu Asp Asp Tyr Leu Lys Val Leu Gln Arg Lys Gln 
                725                 730                 735     


Met Ala Arg Ala Lys Glu Val Asn Glu Lys Glu Glu Gly Asn Asn Asn 
            740                 745                 750         


Tyr Ile Gln Phe Ile Arg Asp Val Val Val Trp Ala Phe Gly Ala Tyr 
        755                 760                 765             


Leu Glu Asn Lys Leu Lys Asn Tyr Lys Asn Glu Leu Gln Pro Pro Leu 
    770                 775                 780                 


Ser Lys Glu Asn Ile Gly Leu Asn Asp Thr Leu Lys Glu Leu Phe Pro 
785                 790                 795                 800 


Glu Glu Lys Val Lys Ser Pro Phe Asn Ile Lys Cys Arg Phe Ser Ile 
                805                 810                 815     


Ser Thr Phe Ile Asp Asn Lys Gly Lys Ser Thr Asp Asn Thr Ser Ala 
            820                 825                 830         


Glu Ala Val Lys Thr Asp Gly Lys Glu Asp Glu Lys Asp Lys Lys Asn 
        835                 840                 845             


Ile Lys Arg Lys Asp Leu Leu Cys Phe Tyr Leu Phe Leu Arg Leu Leu 
    850                 855                 860                 


Asp Glu Asn Glu Ile Cys Lys Leu Gln His Gln Phe Ile Lys Tyr Arg 
865                 870                 875                 880 


Cys Ser Leu Lys Glu Arg Arg Phe Pro Gly Asn Arg Thr Glu Leu Glu 
                885                 890                 895     


Lys Glu Thr Glu Leu Leu Ala Glu Leu Glu Glu Leu Met Glu Leu Val 
            900                 905                 910         


Arg Phe Thr Met Pro Ser Ile Pro Glu Ile Ser Ala Lys Ala Glu Ser 
        915                 920                 925             


Gly Tyr Asp Thr Met Ile Lys Lys Tyr Phe Lys Asp Phe Ile Glu Lys 
    930                 935                 940                 


Lys Val Phe Lys Asn Pro Lys Thr Ser Asn Leu Tyr Tyr His Ser Asp 
945                 950                 955                 960 


Ser Lys Thr Pro Val Thr Arg Lys Tyr Met Ala Leu Leu Met Arg Ser 
                965                 970                 975     


Ala Pro Leu His Leu Tyr Lys Asp Ile Phe Lys Gly Tyr Tyr Leu Ile 
            980                 985                 990         


Thr Lys Lys Glu Cys Leu Glu Tyr  Ile Lys Leu Ser Asn  Ile Ile Lys 
        995                 1000                 1005             


Asp Tyr  Gln Asn Ser Leu Asn  Glu Leu His Glu Gln  Leu Glu Arg 
    1010                 1015                 1020             


Ile Lys  Leu Lys Ser Glu Lys  Gln Asn Gly Lys Asp  Ser Leu Tyr 
    1025                 1030                 1035             


Leu Asp  Lys Lys Asp Phe Tyr  Lys Val Lys Glu Tyr  Val Glu Asn 
    1040                 1045                 1050             


Leu Glu  Gln Val Ala Arg Tyr  Lys His Leu Gln His  Lys Ile Asn 
    1055                 1060                 1065             


Phe Glu  Thr Leu Tyr Arg Ile  Phe Arg Ile His Val  Asp Ile Ala 
    1070                 1075                 1080             


Ala Arg  Met Val Gly Tyr Thr  Gln Asp Trp Glu Arg  Asp Met His 
    1085                 1090                 1095             


Phe Leu  Phe Lys Ala Leu Val  Tyr Asn Gly Val Leu  Glu Glu Arg 
    1100                 1105                 1110             


Arg Phe  Glu Ala Ile Phe Asn  Asn Asn Asp Asp Asn  Asn Asp Gly 
    1115                 1120                 1125             


Arg Ile  Val Lys Lys Ile Gln  Asn Asn Leu Asn Asn  Lys Asn Arg 
    1130                 1135                 1140             


Glu Leu  Val Ser Met Leu Cys  Trp Asn Lys Lys Leu  Asn Lys Asn 
    1145                 1150                 1155             


Glu Phe  Gly Ala Ile Ile Trp  Lys Arg Asn Pro Ile  Ala His Leu 
    1160                 1165                 1170             


Asn His  Phe Thr Gln Thr Glu  Gln Asn Ser Lys Ser  Ser Leu Glu 
    1175                 1180                 1185             


Ser Leu  Ile Asn Ser Leu Arg  Ile Leu Leu Ala Tyr  Asp Arg Lys 
    1190                 1195                 1200             


Arg Gln  Asn Ala Val Thr Lys  Thr Ile Asn Asp Leu  Leu Leu Asn 
    1205                 1210                 1215             


Asp Tyr  His Ile Arg Ile Lys  Trp Glu Gly Arg Val  Asp Glu Gly 
    1220                 1225                 1230             


Gln Ile  Tyr Phe Asn Ile Lys  Glu Lys Glu Asp Ile  Glu Asn Glu 
    1235                 1240                 1245             


Pro Ile  Ile His Leu Lys His  Leu His Lys Lys Asp  Cys Tyr Ile 
    1250                 1255                 1260             


Tyr Lys  Asn Ser Tyr Met Phe  Asp Lys Gln Lys Glu  Trp Ile Cys 
    1265                 1270                 1275             


Asn Gly  Ile Lys Glu Glu Val  Tyr Asp Lys Ser Ile  Leu Lys Cys 
    1280                 1285                 1290             


Ile Gly  Asn Leu Phe Lys Phe  Asp Tyr Glu Asp Lys  Asn Lys Ser 
    1295                 1300                 1305             


Ser Ala  Asn Pro Lys His Thr  
    1310                 1315 


<210>  523
<211>  1330
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  523

Met Lys Arg Glu Lys Asn Ile Thr Ile Met Lys Ile Ser Lys Val Asn 
1               5                   10                  15      


His Arg Arg Thr Ala Val Ala Leu Asn Gly Asp Lys Ser Glu Leu Gly 
            20                  25                  30          


Gly Ile Leu Tyr Glu Ala Pro Val Gln Lys Asp Lys Asn Gly Asn Tyr 
        35                  40                  45              


Asn Asp Val Ile Ala Glu Thr Gly Lys Val Val Asn Glu Ala Leu Asp 
    50                  55                  60                  


Lys Lys Ser Arg Leu Tyr Thr Pro Phe Asn Asn Gln Lys Val Ile Ile 
65                  70                  75                  80  


Asp Lys Asn Leu Gln Arg Tyr Ala Asn Asn Leu Lys Arg Cys Tyr Ile 
                85                  90                  95      


Asn Phe Val Lys Gln Tyr Val Asn Asn Lys Ser Phe Asn Tyr Lys Ala 
            100                 105                 110         


Met Gln Phe Ile Pro Asp Ile Gln Asn Pro Lys Thr Asn Asp Ala Val 
        115                 120                 125             


Asn Tyr Arg Thr Asp Arg Asp Asn Val Tyr Asn Lys Asn Lys Tyr Tyr 
    130                 135                 140                 


Asp Lys Gln Thr Lys Ser Lys Ser Lys Lys Phe Ile Tyr Glu Lys Ile 
145                 150                 155                 160 


Val Ile Pro Gln Asn Glu Gln Asn Ile Val Ile Ser Ala Leu Val Asn 
                165                 170                 175     


Cys Ser Leu Arg Lys Ser Leu Arg Lys Asp Val Ser Tyr Lys Thr Lys 
            180                 185                 190         


Ser Gly Glu Ile Lys Thr Tyr Asn Leu Pro Glu Leu Val Lys Lys Ser 
        195                 200                 205             


Met Arg Phe Tyr Cys Leu Glu Gly Gln Arg Glu Pro Asp Glu Lys Glu 
    210                 215                 220                 


Lys Tyr Glu Met Tyr Ile Leu Phe Ser Tyr Met Lys Glu Asp Lys Arg 
225                 230                 235                 240 


Thr Lys Asn Thr Asp Leu Leu Val Lys Ser Ile Ser Asn Gln Asn Thr 
                245                 250                 255     


Lys Val Lys Val Glu Asp Ile Asp Gly Asn Lys Leu Leu Lys Leu Ser 
            260                 265                 270         


Ile Ala Asp Thr Lys Lys Lys Pro Leu Trp Glu Tyr Leu Ile Lys Tyr 
        275                 280                 285             


Ala Asp Ser Ser Arg Gln Arg Glu Leu Met Tyr Asp Ile Arg Lys Lys 
    290                 295                 300                 


Ile Ile Leu Tyr Val Ala Gly Ile Glu Glu Tyr Glu Asn Ile Lys Glu 
305                 310                 315                 320 


Asp Ser Gly Leu Ser Lys Val Ser Trp Ser Lys Tyr Asn Ile Ser Asp 
                325                 330                 335     


Asn Lys Met Phe Leu Asp Ile Asn Ser Cys Thr Asp Lys Arg Lys Gln 
            340                 345                 350         


Asn Leu Glu Ile Lys Ile Arg Glu Ala Asn Ile Glu His Tyr Arg Asn 
        355                 360                 365             


Ala Ser Ser Lys Leu Cys Asp Asp Glu Ser Ile Phe Trp Phe Gln His 
    370                 375                 380                 


Phe Glu Gly Val Ile Glu Thr Leu Phe Ser Lys Lys Ser Lys Ile Ser 
385                 390                 395                 400 


Glu Glu Arg Leu Gly Cys Ala Tyr Ile Cys Asp Tyr Leu Trp Lys Asp 
                405                 410                 415     


Phe Leu Ser Tyr Leu Ala Ala Lys Tyr Ile Asp Leu Gly Lys Gly Val 
            420                 425                 430         


Tyr His Phe Thr Met Lys Asp Lys Leu Asp Met Leu Asn Lys Asn Glu 
        435                 440                 445             


Ala Val Thr Asp Leu Arg Phe Gly Ile Val Ser Glu Lys Tyr Glu Lys 
    450                 455                 460                 


Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Glu Leu 
465                 470                 475                 480 


Asp Arg Asn Ile Ala Ala Tyr Val Thr Phe Ala Ala Asp Ile Phe Ala 
                485                 490                 495     


Lys Ser Val Ile Lys Ser Asp Tyr Arg Thr Lys Lys Asp Asn Asn Ser 
            500                 505                 510         


Asp Val Leu Gln Tyr Ser Asp Lys Glu Phe Arg Asn Ser Glu Val Ile 
        515                 520                 525             


Arg Asp Asn Ala Glu Lys Asn Ile Leu Gln Tyr Trp Gly Gly Tyr Ser 
    530                 535                 540                 


Arg Trp Gly Thr Glu Ser Ser Lys Leu Pro Glu Asn Asn Lys Val Ser 
545                 550                 555                 560 


Asp Phe Ala Lys Leu Asp Val Ser Asp Leu Cys Ile Asp Ile Lys Lys 
                565                 570                 575     


His Leu Ala Gly Ile Arg Asn Ser Ser Val His Tyr Thr Thr Lys Ile 
            580                 585                 590         


Lys Asn Glu Ser Ala Ala Asp Gly Ser Asn Val Lys Ile Leu Phe Glu 
        595                 600                 605             


Lys Asp Leu Ala Asp Ile Asn Ile Ile Tyr Ala Asp Lys Tyr Tyr Ser 
    610                 615                 620                 


Asn Asn Val Trp Met Phe Tyr Ser Leu Glu Asp Ile Asn Lys Leu Ile 
625                 630                 635                 640 


Ala Phe Leu Tyr Lys Glu Lys Arg Val Ile Arg Gln Val Gln Ile Pro 
                645                 650                 655     


Ser Phe Ser Arg Ile Leu Lys Arg Lys Ala Met Gln Asp Val Ile Asn 
            660                 665                 670         


Glu Ile Phe Lys Asp Asp Phe Asp Glu Asn Ile Val Asn Pro Glu Leu 
        675                 680                 685             


Lys Glu Lys Tyr Arg Asn Ser Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
    690                 695                 700                 


Tyr Asn Ala Phe Ile Ile Gln Pro Glu Leu Lys Glu Lys Phe Lys Asp 
705                 710                 715                 720 


Lys Ile Lys Thr Met Lys Ser Glu Leu Tyr Asn Lys Leu Lys Thr Ile 
                725                 730                 735     


Asp Lys Lys Glu Tyr Lys Ala Leu Tyr Cys Met Leu Ser Asn Glu Glu 
            740                 745                 750         


Ser Ala Leu Lys Asn Phe Ala Asp Arg Ile Tyr Ser Val Asp Gly Asp 
        755                 760                 765             


Asn Val Ser Phe Ala Asp Ile Cys Lys Ile Leu Met Thr Asp Tyr Asn 
    770                 775                 780                 


Met Gln Asn Gln Glu Lys Lys Asn Ile Glu Ser Met Glu Gln Lys Lys 
785                 790                 795                 800 


Lys Asn Lys Gly Lys Asp Glu Asn Tyr Lys His Phe Pro Leu Leu Leu 
                805                 810                 815     


His Lys Val Leu Lys Glu Leu Phe Ile Glu Tyr Leu Lys Gln Thr His 
            820                 825                 830         


Glu Leu Glu Phe Leu Arg Asn Asn Ile Cys Ile Lys Ser Asp Val Thr 
        835                 840                 845             


Met Glu Ser Phe Glu Ser Gln Ile Lys Gly Val Glu Ile Tyr Lys Asp 
    850                 855                 860                 


Leu Lys Glu Lys Ile Asp Lys Asn Asn Ser Leu Leu Asp Trp Tyr Val 
865                 870                 875                 880 


Ile Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asn 
                885                 890                 895     


Ile Lys Asn Tyr Ile Gln Phe Ala Thr Asn Ile Asp Lys Gly Ala Glu 
            900                 905                 910         


Ser Val Lys Asn Leu Thr Glu Ser Gly Met Val Lys Arg Ile Gln Tyr 
        915                 920                 925             


Tyr Asp Asp Ile Val Arg Thr Leu Glu Phe Ser Ala Gln Tyr Ile Gly 
    930                 935                 940                 


Lys Ile Ser Asn Asn Ile Asn Asp Tyr Phe Asn Ser Glu Asp Glu Tyr 
945                 950                 955                 960 


Val Ser Phe Leu Ser Lys Tyr Val Gly Phe Ile Asn Asp Lys Ser Glu 
                965                 970                 975     


Asp Val Leu Thr Glu Leu Lys Asp Phe Cys Arg Glu Lys Ile Asn Asn 
            980                 985                 990         


Gly Ser Gln Ile Ile Gly Ile Tyr  Tyr Gly Gly Asp Asn  Val Ile Ile 
        995                 1000                 1005             


Asn Arg  Asn Val Ile Tyr Ala  Gln Met Tyr Ser Asn  Ala Glu Val 
    1010                 1015                 1020             


Phe Ser  Asn Ile Tyr Lys Lys  Val Thr Lys Asn Asp  Ile Ile Asn 
    1025                 1030                 1035             


Tyr Tyr  Glu Lys Gln Asn Asp  Leu Lys Asp Val Phe  Lys Ser Gly 
    1040                 1045                 1050             


Val Cys  Gln Asn Glu Asp Glu  Gln Arg Ser Leu Cys  Glu Phe Gln 
    1055                 1060                 1065             


Gln Leu  Lys Asn Arg Ile Glu  Leu Thr Glu Leu Ser  Thr Tyr Ala 
    1070                 1075                 1080             


Asp Met  Val Asn Asp Phe Met  Ala Gln Phe Val Glu  Trp Ala Tyr 
    1085                 1090                 1095             


Leu Arg  Glu Arg Asp Leu Met  Tyr Phe Gln Leu Gly  Ile His Tyr 
    1100                 1105                 1110             


Ile Arg  Leu Phe Tyr Ser Asp  Asn Val Leu Asp Glu  Lys Tyr His 
    1115                 1120                 1125             


Lys Leu  Ser Asp Asn Val Ile  Asp Ile Glu Glu Gly  Ala Leu Leu 
    1130                 1135                 1140             


Tyr Gln  Ile Val Ala Met Tyr  Asp Tyr Glu Leu Arg  Ile Phe Glu 
    1145                 1150                 1155             


Thr Asp  Asn Ser Gly Asn Ala  Lys Arg Ile Gly Gln  Gly Gly Pro 
    1160                 1165                 1170             


Gly Lys  Ser Ile Pro Val Phe  Leu Lys Lys Tyr Cys  Asn Gly Thr 
    1175                 1180                 1185             


Asp Val  Tyr Glu Cys Gly Leu  Glu Leu Phe Glu Asp  Ile Asn Gln 
    1190                 1195                 1200             


His Glu  His Ile Ile Arg Phe  Arg Asn Asp Ile Ala  His Met Arg 
    1205                 1210                 1215             


Tyr Met  Ser Asn Gln Ala Met  Asn Ile Met Ser Ile  Val Ser Asn 
    1220                 1225                 1230             


Ile Tyr  Lys Ser Phe Phe Val  Tyr Asp Thr Lys Leu  Lys Lys Ser 
    1235                 1240                 1245             


Ile Ser  Leu Val Phe Lys Asn  Ile Leu Met Arg Tyr  Gly Val Ile 
    1250                 1255                 1260             


Ala Asp  Leu Val Phe Ser Tyr  Asn Asn Lys Asn Gln  Ser Ile Lys 
    1265                 1270                 1275             


Asp Asp  Met Asp Ile Asn Ile  Ile Asn Ile Lys Asn  Leu Lys Ser 
    1280                 1285                 1290             


Asp Lys  Tyr Val Tyr Lys Ile  Val Asn Glu Asp Ile  Val Lys Gln 
    1295                 1300                 1305             


Val Glu  Ile Glu Ile Arg Asn  Gln Val Phe Leu Glu  Gln Leu His 
    1310                 1315                 1320             


Asn Leu  Leu Tyr Phe Ser Arg  
    1325                 1330 


<210>  524
<211>  1244
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  524

Met Lys Ile Thr Lys Val Asn His Val Lys Pro Ala Val Ser Thr Glu 
1               5                   10                  15      


Glu Lys Thr Gln Glu Gly Ile Leu Tyr Lys Asn Pro Thr Asp Gly Lys 
            20                  25                  30          


Gly Leu Pro Asp Ile Glu Lys His Val Asp Asp Leu Ile Ala Arg Ala 
        35                  40                  45              


Ser Arg Asn Phe Lys Glu Asn Phe Lys Tyr Tyr Ile Asp Asp Asn Ala 
    50                  55                  60                  


Ser Pro Glu Glu Lys Lys Lys Leu Gln Gln Lys Lys Asn Lys Phe Arg 
65                  70                  75                  80  


Asn Gly Val Ile Glu Ser Leu Lys Asn Gln Asn Met Val Ile Gln Pro 
                85                  90                  95      


Val Glu Leu Glu Glu Gly Asp Ile Gln Ile Ala Leu Ser Leu Val Lys 
            100                 105                 110         


Gly Glu Leu Ser Glu Gly Gly Val Ser Glu Lys Gly Ser Arg Lys Ala 
        115                 120                 125             


Arg Glu Lys Ala Ala Phe Arg Arg Phe Leu Ser Asp Tyr Ala Asn Leu 
    130                 135                 140                 


Asp Glu Ala Phe Arg Met Asp Leu Leu Arg Arg Ile Arg Arg Ile Val 
145                 150                 155                 160 


Leu Ile Tyr Phe Tyr Gly Thr Asp Ser Met Asn Glu Thr Ile Lys Ser 
                165                 170                 175     


Asp Phe Asp Val Trp Asp Asp His Lys Ser Arg Gln Ser Asp Tyr Ser 
            180                 185                 190         


Ala Tyr Ile Lys His Glu Phe Val Ser Thr Ile Val Glu Asn Lys Lys 
        195                 200                 205             


Glu Gln Glu Lys Leu Arg Glu Glu Asn Tyr Asn Gln Leu Lys Asp Ser 
    210                 215                 220                 


Ile Arg Lys Ala Asn Ile Asn Ser Tyr Arg Ser Thr Val Ser Tyr Ile 
225                 230                 235                 240 


Asp Ser Leu Ser Asp Glu Gln Lys Ser Thr Leu Phe Phe Ala Asp Gln 
                245                 250                 255     


Asp Met Ile Asn Tyr Trp Val His His Ile Glu Asp Glu Val Glu Arg 
            260                 265                 270         


Ile Tyr Lys Lys Thr Lys Arg Leu Asn Lys Asp Asn Thr Tyr Lys Leu 
        275                 280                 285             


Cys Lys Gly Tyr Ile Ser Glu Lys Val Trp Lys Gly Ile Ile Asn Tyr 
    290                 295                 300                 


Ile Cys Ile Lys Tyr Ile Ala Ile Gly Lys Val Val Tyr Asn Leu Ala 
305                 310                 315                 320 


Met Glu Asp Leu Gly Gly Asp Lys Asp Glu Asn Leu Gly Glu Leu Ala 
                325                 330                 335     


Ala Ala Phe Lys Asn Gly Ile Ser Ser Phe Asp Tyr Glu Ile Ile Lys 
            340                 345                 350         


Ala Glu Glu Arg Leu Gln Arg Glu Thr Ala Val Tyr Val Ser Phe Ala 
        355                 360                 365             


Ile Asn Asn Phe Leu Ser Ala Thr Val Asp Arg Gly Glu Asp Val Lys 
    370                 375                 380                 


Asp Lys Glu Cys Asp Ile Ala Asp Lys Asn Leu Asn Arg Leu Pro Asn 
385                 390                 395                 400 


Thr Lys Arg Asn Ile Leu Gln Phe Phe Gly Gly Ser Ser Arg Trp Ser 
                405                 410                 415     


Gly Phe Asp Tyr Ser Lys Tyr Ser Ser Asp Glu Thr Gly Glu Tyr Leu 
            420                 425                 430         


Trp Asn Gln Val Arg Glu Ala Leu Tyr Ser Met Arg Asn Glu Ser Phe 
        435                 440                 445             


His Phe Asn Thr Lys Asn Ile Lys Ser Asp Trp Asp Gln Lys Leu Ile 
    450                 455                 460                 


Ser Asp Met Phe Glu Thr Asp Ser Arg Glu Cys Gly Lys Ser Glu Val 
465                 470                 475                 480 


Val Lys Phe Tyr Ser Asn Asn Ile Pro Met Phe Tyr Ser Glu Thr Asp 
                485                 490                 495     


Ile Glu Lys Leu Met His Lys Leu Tyr Asp Asn Tyr Ser Ile Arg Ala 
            500                 505                 510         


Ser Gln Val Pro Ala Phe Asn Thr Val Phe Val Arg Lys Asn Phe Ala 
        515                 520                 525             


Ser Phe Ile Gly Glu Lys Leu Lys Ile His Thr Thr Phe Ser Gly Glu 
    530                 535                 540                 


Glu Leu Gln Gln Phe Gln Ser Ala Leu Tyr Tyr Leu Leu Lys Glu Val 
545                 550                 555                 560 


Tyr Tyr Asn Ala Phe Leu Thr Asp Lys Asn Thr Lys Lys Phe Phe Leu 
                565                 570                 575     


Asp Ala Val Ser Ser Leu Asn Asp Ser Asp Lys Glu His Lys Tyr Ala 
            580                 585                 590         


Val Ile Asp Phe Lys Lys Arg Ile Asn Glu Ile Asn Arg Ser Gly Ser 
        595                 600                 605             


Phe Ser Leu Ser Glu Ile Cys Gln Ile Ile Met Thr Glu Tyr Asn Gln 
    610                 615                 620                 


Gln Asn Asp Lys Trp Met Lys Lys Arg Thr Asn Lys Gly Lys Glu Lys 
625                 630                 635                 640 


Leu Pro Asp Gly Tyr Gln His Tyr Lys Met Leu Leu Leu Glu Ser Leu 
                645                 650                 655     


Arg Asp Ala Phe Val Leu Tyr Leu Asn Ser Asp Thr Ser Tyr Ser Phe 
            660                 665                 670         


Ile Asn Ser Pro Arg Lys Lys Asp Ile Pro Ser Lys Asp Glu Phe Leu 
        675                 680                 685             


Pro Asn Phe Ser Ser Asp Arg Tyr Asp Ser Ile Val Lys Glu Leu Ala 
    690                 695                 700                 


Gln Asn Pro Glu Leu Gln Lys Trp Tyr Val Met Gly Arg Phe Leu Tyr 
705                 710                 715                 720 


Pro Lys Gln Thr Asn Gln Leu Ala Gly Ser Ile Arg Asn Tyr Ile Gln 
                725                 730                 735     


Tyr Lys Trp Asp Ile Lys Arg Arg Ala Glu Asn Thr Gly Asn Ala Val 
            740                 745                 750         


Ala Val Ser Glu Glu Leu Ser Asn Arg Leu Lys Lys Ile Leu Gln Val 
        755                 760                 765             


Ile Glu Ile Cys Thr Lys Met Ala Gly Thr Ile Ser His Glu Ile Thr 
    770                 775                 780                 


Asp Tyr Phe Asp Asp Glu Asp Asp Tyr Ala Ser Tyr Ile Glu Arg Phe 
785                 790                 795                 800 


Leu Asp Tyr Gly Lys Glu Phe Glu Gln Tyr Asp Ile Ser Pro Ser Gly 
                805                 810                 815     


Lys Leu Lys Glu Phe Cys Thr Ser Lys Asn Ile Gly Asp Asn Ser Ser 
            820                 825                 830         


Ile Asp Ile Phe Tyr Asp Gly Lys Asn Pro Ile Leu Asn Arg Asn Ile 
        835                 840                 845             


Val Leu Ser Lys Met Tyr Gly Ser Gly Asp Ile Leu Ala Asp Ala Leu 
    850                 855                 860                 


Ser Asp Asn Arg Val Asn Ile Ala Asp Ile Glu Ala Tyr Tyr Lys Cys 
865                 870                 875                 880 


Lys Asp Lys Leu Thr Lys Tyr Arg Thr Thr Gly Glu Phe Ser Thr Lys 
                885                 890                 895     


Asp Glu Val Val Glu Ile Lys Lys Tyr Gln Glu Leu Lys Asn His Val 
            900                 905                 910         


Glu Phe Arg Asp Ile Val Glu Tyr Ala Glu Leu Leu Asn Glu Leu Gln 
        915                 920                 925             


Gly Gln Leu Ile Asn Trp Thr Tyr Leu Arg Glu Arg Asp Leu Leu Tyr 
    930                 935                 940                 


Tyr Gln Leu Gly Phe His Tyr Ser Cys Leu Lys Asn Asp Ser Asn Lys 
945                 950                 955                 960 


Pro Ser Asp Tyr Lys Ser Ile Val Val Glu Gly Arg Thr Ile Asn Asn 
                965                 970                 975     


Ala Ile Leu His Gln Phe Ala Ser Leu Tyr Ile Asn Gly Val Pro Leu 
            980                 985                 990         


Phe Val Leu Asp Gly Asp Glu Tyr  Lys Arg Asp Lys Glu  Lys Ser Ala 
        995                 1000                 1005             


Gly Gly  Asn Ile Arg Gly Phe  Phe Asp Tyr Cys Lys  Ile Ala Phe 
    1010                 1015                 1020             


Pro Glu  Tyr Thr Asn Lys Phe  Thr Val Tyr Thr Ser  Gly Leu Glu 
    1025                 1030                 1035             


Leu Phe  Glu Thr Val Lys Glu  His Asp Glu Ile Ile  Asn Leu Arg 
    1040                 1045                 1050             


Asn His  Ile Asp His Ser Lys  Tyr Phe Val Met Asn  Pro Ala Val 
    1055                 1060                 1065             


Asn Gly  Gly Arg Ser Met Ile  Asp Ile Tyr Ser Glu  Val Phe Asp 
    1070                 1075                 1080             


Arg Phe  Phe Ser Tyr Asp His  Lys Tyr Arg Lys Asn  Val Pro Asn 
    1085                 1090                 1095             


Val Leu  Phe Asn Ile Cys Met  Lys His Phe Ala Ala  Leu Ser Ile 
    1100                 1105                 1110             


Gly Phe  Ser Thr Gly Glu Lys  Val Val Gln Arg Asp  Lys Glu Arg 
    1115                 1120                 1125             


Lys Glu  Cys Lys Asp Arg Ala  Thr Ile Val Ile Asn  Lys Ile Ser 
    1130                 1135                 1140             


Ala Glu  Pro Phe Thr Tyr Lys  Leu Lys Asn Gly Lys  Val Glu Cys 
    1145                 1150                 1155             


Pro Ala  Lys Ser Glu Arg Phe  Leu Arg Asn Met Val  Ser Leu Leu 
    1160                 1165                 1170             


Tyr Tyr  Arg Asp Asn Ile Pro  Glu Gly Ile Val Tyr  Tyr Thr Gly 
    1175                 1180                 1185             


Lys Leu  Lys Ser Val Ser Pro  Asp Asn Asn Gly Gln  Lys Ile Asp 
    1190                 1195                 1200             


Leu Arg  Asn Ser Arg Asn Lys  Gly Asn Asn Gly Tyr  Ser Lys Lys 
    1205                 1210                 1215             


Asn Lys  Thr Val Gly Lys Lys  Asn Glu Lys Asp Leu  Thr Ser Asn 
    1220                 1225                 1230             


Pro Phe  Asp Asp Leu Phe Ser  Gly Leu Lys Leu 
    1235                 1240                 


<210>  525
<211>  1218
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  525

Met Arg Ile Val Arg Pro Tyr Gly Glu Ser Val Ala Pro Gly Ala Gly 
1               5                   10                  15      


Ser Glu Arg Leu Leu Arg Pro Lys Lys Gln Leu Arg Asp Gln Ile Gly 
            20                  25                  30          


Asp Ala Asp Arg Arg Ile Pro Thr Phe Ala Ala Gly His Asp Glu Leu 
        35                  40                  45              


Val Ile Ala Gln Trp Ile Ser Thr Ile Asp Lys Ile Ala Thr Lys Pro 
    50                  55                  60                  


Lys Gly Asn Lys Glu Pro Thr Pro Arg Gln Arg Ala Leu Arg Glu Lys 
65                  70                  75                  80  


Leu Gly Lys Ala Gly Trp Asp Arg Leu Val Asp Gln Lys Leu Leu Pro 
                85                  90                  95      


Gly Leu Pro Lys Asp Gln Asp Asp Tyr Leu Gly Lys Leu Trp Trp Phe 
            100                 105                 110         


Lys Ile His Pro Tyr Pro Lys Gly Thr Lys Ala Pro Lys Val Val Asn 
        115                 120                 125             


Gly Arg Glu Ile Pro Asp Pro Arg Gly Arg Trp Tyr Ser Arg Phe Val 
    130                 135                 140                 


Cys Asp Val Ala Pro Asp Asp Ile Asp Ala Ala Thr Val Ala Ala Arg 
145                 150                 155                 160 


Val His Glu His Leu His Val Ala Glu Tyr Arg His Gly Thr Glu Gln 
                165                 170                 175     


Lys His Asp Lys Gly Arg Ile Glu Arg Arg Ala Arg Ser Ile Ala Lys 
            180                 185                 190         


Asn Thr Ala Ser Leu Ala Gln Val Thr Lys Glu Arg Pro Thr Trp Thr 
        195                 200                 205             


Glu Asp Asp Val Ala Thr Tyr Ala Gln Thr Ala Gly Asp Val Ala Thr 
    210                 215                 220                 


Ala Ile Lys Gln Ala Ala Glu Ala Arg Glu Ala Asp Asn Arg Arg Val 
225                 230                 235                 240 


Gly Ala Asp Val Ala Ala Glu Val Leu Tyr Pro Ala Phe Gly Lys Leu 
                245                 250                 255     


Phe Pro Asn Lys Gly Ile Lys Glu Leu Glu Asn Gln Ser Gly Leu Pro 
            260                 265                 270         


Ala Leu His Leu Ala Ile Arg Asp Phe Tyr Gln Arg Arg Leu Lys Arg 
        275                 280                 285             


His Lys Lys Asp Gln Pro Glu His Lys Met Ala Arg Arg Lys Val Ser 
    290                 295                 300                 


Thr Leu Leu Pro Ala Asp Met Ala Gly Leu Ala Ala Met Leu Arg His 
305                 310                 315                 320 


Thr Ala Ala Asn Arg Asp Val Ala Ala Leu Val Arg Leu Gly Lys Val 
                325                 330                 335     


Ile His Tyr Glu Ala Ala Phe Ala Ala Gly Gln Lys Ala Ala Asp Gly 
            340                 345                 350         


Asp Ala Pro Ala His Val Leu Glu Lys Trp Pro Ala Glu Val Lys Ala 
        355                 360                 365             


Ser His Tyr Trp Ser Ser Glu Gly Gln Ala Glu Ile Lys Arg Asn Glu 
    370                 375                 380                 


Ala Phe Val Arg Ile Trp Arg His Ser Leu Ala Leu Ala Ala Gln Thr 
385                 390                 395                 400 


Leu Arg Asp Trp Ala Ser Pro Asp Gly Ser Phe His Thr Asp Ile Leu 
                405                 410                 415     


Ser Glu Lys Gln Phe Glu Thr Leu Thr Lys Asn Leu Asp Leu Asp His 
            420                 425                 430         


His Ala Arg Lys Leu Ala Val Leu Leu Gly Asn Arg Ala Glu Phe Phe 
        435                 440                 445             


Leu Lys Gly Arg Gly Asp Ala Phe Gln Lys Gln Thr Leu Lys Leu Ala 
    450                 455                 460                 


Leu Gln Gly Leu Thr Gln Leu Arg His Asn Ser Phe His Phe Asn Gly 
465                 470                 475                 480 


Arg Gly Gly Phe Ala Asp Ala Leu Lys Phe Thr Arg Lys Pro Glu Ile 
                485                 490                 495     


Thr Ala Asp Gln His Met Trp Asp Ala Leu Gly Ala Leu Trp Ala Thr 
            500                 505                 510         


Asp Leu Glu Glu Arg Gly Lys Arg Leu Ile Asp Thr Leu Glu Ala Ala 
        515                 520                 525             


His Leu His His Phe Phe Asp Trp Glu His Asn Lys Arg Leu Ile Gly 
    530                 535                 540                 


Ala Val Ala Arg Ala Lys Leu Ala Glu Gly Ala Glu Asp Leu Pro Leu 
545                 550                 555                 560 


Pro Arg Phe Arg Arg Leu Leu Asp Arg Ala Ala Asn Ile Arg Gly Lys 
                565                 570                 575     


Asp Gly Ile Asn Leu Arg Leu Pro Lys Pro Val Asn Arg Gln Asp Met 
            580                 585                 590         


Glu Asp Phe Pro Ala Leu His Ala Lys Tyr Val Ala Leu Lys Leu Leu 
        595                 600                 605             


Tyr Glu Asn Pro Phe Arg Gln Trp Val Gly His Arg Asp Arg Arg Asp 
    610                 615                 620                 


Leu Val Asn Lys Leu Ile Asp Arg Ala Val Arg Arg Ala Asp Lys Ala 
625                 630                 635                 640 


Ala Lys Asp Leu His Gly Lys Ala Asp Ala Asp Arg Arg Leu Ile Ile 
                645                 650                 655     


Thr Ala Lys Ala Lys Gly Leu Gly Arg Leu Gly Glu Gly Glu Lys Leu 
            660                 665                 670         


His Asp Phe Ala Phe Arg Leu Ser Arg Glu Thr Ala Ser Glu Met Arg 
        675                 680                 685             


Val Gln Arg Gly Tyr Asp Ser Asp Gly Glu Arg Ala Arg Glu Gln Ala 
    690                 695                 700                 


Ala Phe Ile Glu Glu Leu Leu Ile Asp Val Leu Ala Gln Ala Phe Asp 
705                 710                 715                 720 


His Tyr Leu Arg Lys Lys Lys Phe Asp Phe Leu Val Asp Leu Arg Ala 
                725                 730                 735     


Asp Glu Pro Arg Pro Lys Glu Pro Lys Cys Ala Leu Arg Arg Pro Val 
            740                 745                 750         


Leu Asp Ala Glu Gly Ala Ala Ala Pro Gln Trp Gln Val Leu Leu Tyr 
        755                 760                 765             


Phe Leu Leu His Leu Ile Pro Val Asp Asp Ile Gly Arg Leu Val His 
    770                 775                 780                 


Gln Ile Arg Lys Trp Asp Ile Thr Ala Gly Lys Ala Ala Gly Thr Thr 
785                 790                 795                 800 


Arg Ala Ala Asp Asp Asp Val Asp Arg Val Ala Arg Thr Leu Thr Leu 
                805                 810                 815     


Tyr Leu Asp Met His Asp Ala Lys Phe Thr Gly Asp Gln Ala Leu Gln 
            820                 825                 830         


Ala Leu Ala Pro Leu His Glu Leu Tyr Ala Ser Lys Glu Thr Phe Glu 
        835                 840                 845             


Arg Phe Phe Leu Arg Lys Ala Thr Asp Asp Asn Glu Tyr Leu Pro Arg 
    850                 855                 860                 


Arg Gly Leu Arg Glu Ile Leu Arg Phe Gly His Leu Pro Pro Leu Arg 
865                 870                 875                 880 


Ala Ile Phe Ala Ala His Lys Val Asp Asp Asp Thr Val Gln Lys Val 
                885                 890                 895     


Glu Ala Ala Glu Lys Gly Pro Leu Val Ala Ala Gln Arg Glu Arg Glu 
            900                 905                 910         


Arg Leu His Lys Leu Trp Val Asp Gln Arg Arg Lys Leu Gly Ala Glu 
        915                 920                 925             


Asp Leu Arg Cys Tyr Val Asp Thr Leu Ala Glu Val Thr Arg His Arg 
    930                 935                 940                 


His Ala Ala Ala His Val Arg Leu Val Asp His Val Glu Leu His Arg 
945                 950                 955                 960 


Leu Met Leu Ala Val Leu Gly Arg Leu Leu Asp Phe Ala Gly Leu Phe 
                965                 970                 975     


Glu Arg Asp Leu Tyr Phe Ala Met Leu Ala Leu Ile Tyr Arg Ala Pro 
            980                 985                 990         


Ser Ser Pro Gln Ala Val Leu Asp  Glu Ala Asp Arg Glu  Leu Leu Arg 
        995                 1000                 1005             


Arg Gly  Gln Ile Val Glu Thr  Trp Arg Lys Leu Gln  Asp Ser Thr 
    1010                 1015                 1020             


Leu Lys  Asp Glu Leu Ala Gln  Leu Phe Asp Pro Thr  Ser Gly Arg 
    1025                 1030                 1035             


Val Ile  Arg Val Arg Asn Asp  Phe Ala His Phe Asn  Met Leu Asn 
    1040                 1045                 1050             


Pro Arg  Arg Ser Arg Gly Ala  Thr Ile Asp Leu Thr  Ala Gln Val 
    1055                 1060                 1065             


Asn Ala  Ala Arg Arg Leu Met  Gly Tyr Asp Arg Lys  Leu Lys Asn 
    1070                 1075                 1080             


Ala Val  Ala Gln Ser Val Ile  Glu Leu Val Ala Arg  Glu Gly Leu 
    1085                 1090                 1095             


His Leu  Asp Trp Gly Met Gln  Val Leu Asp Gly Ala  His Val Leu 
    1100                 1105                 1110             


Val Asp  Ala Arg Val Arg Gly  Lys Gln Ala Ala His  Leu Gly Asn 
    1115                 1120                 1125             


Leu Gly  Leu Phe Glu Lys Gly  Gln Gly Glu Arg Glu  Lys Lys Pro 
    1130                 1135                 1140             


Ala His  Arg Leu Thr Glu Thr  Leu Ser Gly Pro His  Leu Ala Glu 
    1145                 1150                 1155             


Met Ala  Ala Thr Leu Phe Ala  Gly Arg Val Ala His  Ala Thr Asp 
    1160                 1165                 1170             


Ala Ala  Ala Leu Pro Arg Ala  Ala Ile Asp Trp Gln  Arg Ser Ala 
    1175                 1180                 1185             


Ala Pro  Glu Thr Asn Thr Lys  Gln Ala His Asn His  Pro Gln Arg 
    1190                 1195                 1200             


Pro Pro  Lys Pro Arg Ile Gln  Arg Pro Pro Leu Gln  Ala Ala Lys 
    1205                 1210                 1215             


<210>  526
<211>  999
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  526

Met Gln Lys Ala Gln Asn Leu Arg Lys Ile Leu Gly Asn Ala Ala Trp 
1               5                   10                  15      


Lys Lys Leu Gly Asp Lys Lys Leu Leu Gln Lys Leu Ala Gly Thr Glu 
            20                  25                  30          


Lys Glu Lys Asn Lys Leu Lys Lys Ile Trp Asp Trp Lys Ile Asn Ala 
        35                  40                  45              


Thr Gln Pro Lys Ala Pro Lys Thr Ile Glu Gly Arg Trp Tyr Lys Val 
    50                  55                  60                  


Phe Val Asp Asp Ile Lys Pro Val Glu Lys Asn Ala Thr Glu Ile Ser 
65                  70                  75                  80  


Asp Lys Ile Tyr Lys His Leu Tyr Glu Lys Ala Tyr Arg Phe Pro Val 
                85                  90                  95      


Lys Pro Asp Lys Asp Lys Asn Gln Lys Met Pro Thr Arg Gln Ser Gly 
            100                 105                 110         


Arg Met Glu Ser Ser Gln Pro Arg Cys His Lys Glu Gly Leu Ile Lys 
        115                 120                 125             


His Arg Ala Asn Ser Ile Glu Asn Asn Val Leu Glu Arg Thr Glu Gln 
    130                 135                 140                 


Lys Ala Ala Leu Tyr Asp Asp Ser Asp Lys Glu Thr Tyr Ile Lys Lys 
145                 150                 155                 160 


Ala Gly Asp Ile Ala Asp Ala Ile Arg Lys Ala Val Leu Asp Glu Trp 
                165                 170                 175     


Arg Glu Pro Tyr Ala Ser Pro Glu Ala Arg Asn Ala Pro Asn Asn Gln 
            180                 185                 190         


Gln Arg Lys Asn Gly Ser Ser Ser Arg Asn Pro Gln Gln Gln Asn Arg 
        195                 200                 205             


Asn Thr Thr Glu Gly Tyr Lys Asp Arg Pro Tyr Glu Ile Ala Val Arg 
    210                 215                 220                 


Thr Leu Arg Asp Thr Arg Ile Lys Val Phe Asp Gly Leu Lys Ala Phe 
225                 230                 235                 240 


Cys Ala Ala Lys Glu Lys Asn Pro Ser Leu Leu Asn Leu His Leu Gln 
                245                 250                 255     


Ile Lys Glu Thr Tyr Lys Tyr Leu Leu Lys Gly Arg Lys Lys Leu Asn 
            260                 265                 270         


Asp Lys Leu Glu Lys Ile Leu Pro Glu Asn Asn Asp Ala Leu Phe Arg 
        275                 280                 285             


Leu Met Glu Glu Arg Gln Lys Asn Arg Asp Val Asn His Leu Ile Arg 
    290                 295                 300                 


Leu Gly Lys Val Ile His Tyr Glu Ala Ser Val Lys Ser Gly Lys Gln 
305                 310                 315                 320 


Thr Thr Asn Asp Gly Arg Asp Asp Val Ala Ala Ser Thr Thr Asp Leu 
                325                 330                 335     


Ser Glu Glu Asp Ile Ile Asn Ser Arg Phe Trp Ser Ser Asp Gly Gln 
            340                 345                 350         


Thr Glu Ile Lys Gln Asn Glu Ala Phe Val Arg Ile Trp Arg Asn Val 
        355                 360                 365             


Leu Ala Phe Ala Ala Arg Thr Leu Lys Asp Trp Ala Asp Pro Gly Asn 
    370                 375                 380                 


Asn Ile Pro Cys Asp Ile Leu Ile Asn Arg Lys Lys Ala Leu Cys His 
385                 390                 395                 400 


Phe Asn Val Asp Asn Phe Asp Lys Lys Tyr Lys Ile Leu Phe Gly Asp 
                405                 410                 415     


Arg Pro Glu Glu Asp Lys Lys Phe Ser Ala Thr Ser Asp Lys Gln Gln 
            420                 425                 430         


Gln Thr Val Ala Pro Ala Leu Lys Lys Glu Glu Lys Lys Ala Leu Leu 
        435                 440                 445             


Glu Phe Ser Leu Gln Ser Ile Tyr Asn Leu Arg Asn Ala Ala Phe His 
    450                 455                 460                 


Phe Lys Gly Met Gly Thr Phe Ile Lys Glu Leu Glu Lys Glu Thr Asp 
465                 470                 475                 480 


Lys Asn Val Ser Gly Ile Leu Lys Asp Ile Tyr Lys Thr Asp Cys Glu 
                485                 490                 495     


Lys Arg Gln Glu Ile Arg Lys Lys Ile Met Glu Gly Ala His Phe His 
            500                 505                 510         


Lys Phe Phe Gly Arg Gly Glu Ile Glu Lys Ile Trp Arg Glu Leu Thr 
        515                 520                 525             


Ser Ala Lys Pro Ser Ile Leu Pro Leu Pro Lys Leu Lys Arg Val Leu 
    530                 535                 540                 


Glu Arg Ala Glu Asp Ala Trp Lys Asp Lys Asp Thr Leu Gln Leu Pro 
545                 550                 555                 560 


Pro Tyr Ser Thr Ser Asp Glu Arg Glu Ala Cys Glu Trp Ala Cys Cys 
                565                 570                 575     


Gln Tyr Thr Ala Thr Lys Leu Leu Tyr Asp Arg Pro Phe Lys Asn Trp 
            580                 585                 590         


Leu Asp Glu Gln Glu His Cys Ile Ile Asn Gly Tyr Ile Lys Arg Ala 
        595                 600                 605             


Leu Glu His Thr Thr Gln Ala Ala Gln Arg Met Asn Gly Lys Asp Lys 
    610                 615                 620                 


Asp Lys Asp Tyr Ile Glu Leu Ile Thr Ala Lys Ala Lys Asn Ile Gly 
625                 630                 635                 640 


Glu Leu Lys Asp Lys Glu Lys Phe Glu Asp Phe Phe Phe Glu Leu Ile 
                645                 650                 655     


Ala Ala Thr Ala Thr Glu Arg Pro Val Gln Asn Phe Tyr Gln Ser Asp 
            660                 665                 670         


Gly Asp Ala Ala Lys Glu Gln Ala Glu Tyr Ile Glu Lys Phe Lys Cys 
        675                 680                 685             


Asp Val Ile Ala Leu Ala Phe Glu Lys Tyr Leu Lys Glu Lys Ile Lys 
    690                 695                 700                 


Asn Ile Lys Ala Phe Cys Glu Lys Glu Arg Thr Glu Lys Pro Arg Thr 
705                 710                 715                 720 


Ser His Pro Lys Gln Gln Glu Asn Phe Asp Tyr Glu Ser Leu Thr Ser 
                725                 730                 735     


Thr Gln Ile Ala Glu Phe Glu Leu Trp Gln Ala Trp Gln Glu Lys Leu 
            740                 745                 750         


Tyr Phe Leu Leu His Leu Ile Pro Val Glu Glu Val Gly Ser Leu Arg 
        755                 760                 765             


Gln Gln Leu Lys Lys Trp Glu Ile Val Thr Arg Lys Ser His Gly Lys 
    770                 775                 780                 


Glu Gly Arg Glu Lys Asp Ile Leu Lys Val Leu Gly Val Phe Asp Leu 
785                 790                 795                 800 


Tyr Ile Ala Met His Asp Ala Gln Phe Val Glu Ala Glu Leu Lys Ser 
                805                 810                 815     


Leu Ser Ala Glu Asp Lys Lys Thr Ala Glu Ala Leu Phe Glu Asn Lys 
            820                 825                 830         


Asp Asp Phe Glu Lys Ile Phe Pro Lys Lys Gln Gly Gly Ser Glu Val 
        835                 840                 845             


Glu His Leu Pro Ile Arg Gly Leu Arg Glu Met Lys Arg Phe Gly Arg 
    850                 855                 860                 


Gly Ile Leu His Asn Val Tyr Glu Lys His Lys Ile Lys His Glu Asp 
865                 870                 875                 880 


Val Glu Arg Trp Glu Lys Leu Glu Lys Thr Ile Ala Glu Glu Gln Lys 
                885                 890                 895     


Lys Leu Lys Lys Leu His Glu Glu Trp Val Val Ser Lys Asn Lys Thr 
            900                 905                 910         


Lys Trp Thr Lys Glu Ser Glu Tyr Lys Ser Ala Leu Lys Lys Val Glu 
        915                 920                 925             


Glu Tyr Arg His Leu Lys Ala Gln Val Met Leu Gln Asn His Val Arg 
    930                 935                 940                 


Leu His Arg Leu Leu Met Lys Val Leu Gly Arg Leu Ile Asp Tyr Ser 
945                 950                 955                 960 


Gly Leu Trp Glu Arg Asp Leu Tyr Phe Val Leu Leu Ala Leu Phe Tyr 
                965                 970                 975     


Gln Lys Glu Gln Ser Arg Asp Lys Asp Asn Lys Ile Ala Asp Asp Glu 
            980                 985                 990         


His Val Arg Phe Leu Lys Lys 
        995                 


<210>  527
<211>  1268
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  527

Met Lys Val Ser Lys Val Asn His Arg Arg Ala Ala Val Ala Val Asn 
1               5                   10                  15      


Lys Lys Ser Val Thr Val Asn Gly Ile Leu Tyr Asp Ala Pro Val Lys 
            20                  25                  30          


Lys Asn Val Lys Thr Gly Asn Met Ser Ala Tyr Val Ser Ser Lys Tyr 
        35                  40                  45              


Val Ile Asp Asn Val Val Lys Asn Ser Ser Arg Leu Tyr Ser Pro Phe 
    50                  55                  60                  


Ser Ser Lys Arg Ile Val Ile Asp Arg Glu Lys Ile Arg Ile Ala Asp 
65                  70                  75                  80  


Arg Leu Lys Gln Cys Tyr Val Asn Phe Val Lys Tyr Tyr Leu Ser Asn 
                85                  90                  95      


Gly Ser Leu Asn Glu Gln Gln Met Arg Phe Asn Pro Asn Asn Thr Tyr 
            100                 105                 110         


Met Ala Asp Ser Arg Val His Phe Cys Val Pro Ser Gly Ile Asp Ile 
        115                 120                 125             


Glu Ser Leu Ile Asn Ser Ile Val Asp Ser Ser Leu Arg Lys Ser Leu 
    130                 135                 140                 


Lys Arg Thr Tyr Arg Phe Glu Thr Asn Tyr Gly Glu Lys Asn Thr Phe 
145                 150                 155                 160 


Asn Leu Pro Asp Leu Val Lys Lys Ser Ile Lys Ile Tyr Cys Thr Asp 
                165                 170                 175     


Glu Lys Arg Lys Leu Asn Asp Arg Glu Glu Gln Glu Met Tyr Val Leu 
            180                 185                 190         


Phe Ser Tyr Met Tyr Glu Asp Lys Tyr Lys Asp Arg Gln Lys Val Leu 
        195                 200                 205             


Ile Ala Asn Ser Ile Ser Asn Gln Ala Thr Lys Val Lys Val Cys Asp 
    210                 215                 220                 


Asp Glu Ser Arg Leu Ile Lys Leu Ser Ile Ala Asp Thr Lys Lys Lys 
225                 230                 235                 240 


Pro Leu Trp Asp Phe Ile Val Asp Tyr Ala Asn Ser Asp Lys Asn Gly 
                245                 250                 255     


Gln Tyr Thr Ile Leu Arg Asn Ile Arg Lys Ser Ile Val Leu Phe Val 
            260                 265                 270         


Cys Gly Val Asp Val Tyr Arg Asn Ile Glu Asn Asn Asp Asn Leu Asp 
        275                 280                 285             


Ile Trp Lys Trp Glu Glu Tyr Gly Ile Gln Glu Ser Gln Leu Phe Val 
    290                 295                 300                 


Lys Ile Glu Asn Cys Tyr Thr Thr Lys Gly Glu Asp Ile Ala Leu Asn 
305                 310                 315                 320 


Glu Ile Arg Asn Val Asn Leu Asp His Tyr Met Lys Ala Ile Gly Val 
                325                 330                 335     


Leu Asp Asp Glu Arg Ser Lys Phe Trp Phe Gln His Tyr Glu Asn Thr 
            340                 345                 350         


Ile Glu Ala Leu Phe Ser Lys Lys Ser Lys Arg Lys Ile Glu Arg Ile 
        355                 360                 365             


Lys Thr Ala Tyr Leu Cys Glu Tyr Leu Trp Lys Asn Phe Cys Ser Tyr 
    370                 375                 380                 


Val Ala Leu Lys Tyr Val Asp Leu Gly Lys Gly Val Tyr His Phe Thr 
385                 390                 395                 400 


Met Ser Asp Lys Leu Ser Leu Met Asn Lys Asn Thr Asn Glu Asn Gly 
                405                 410                 415     


Ile Lys Phe Gly Glu Val Asp Ser Arg Phe Asn Lys Gly Ile Ser Ser 
            420                 425                 430         


Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Thr Ile Asp Arg Asn Ile 
        435                 440                 445             


Ser Thr Tyr Thr Thr Phe Ala Thr Asn Ile Phe Ala Lys Ser Val Ile 
    450                 455                 460                 


Lys Asp Ser Tyr Arg Gln Lys Lys Ala Gly Asn Ser Asp Ala Leu Gln 
465                 470                 475                 480 


Tyr Asp Asp Glu Thr Tyr Tyr Asn Arg Lys Ala Met Asn Pro Tyr Ala 
                485                 490                 495     


Leu Lys Arg Val Leu Arg Tyr Trp Gly Gly Gln Ser Arg Trp Lys Ser 
            500                 505                 510         


Glu Leu Glu Glu Leu Asn Val Ala Glu Leu Cys Ile Asp Ile Lys Asn 
        515                 520                 525             


Arg Leu Ser Lys Ile Arg Asn Ser Gly Val His Tyr Thr Ser Thr Ser 
    530                 535                 540                 


Ala Leu Lys Gly Asn Asp Asp Asp Ser Ile Val Gly Met Leu Ile Lys 
545                 550                 555                 560 


Lys Asp Phe Asp Asp Ile Lys Asp Val Tyr Ala Ser Lys Tyr Tyr Ser 
                565                 570                 575     


Asn Asn Val Trp Met Phe Tyr Asn Thr Asp Lys Ile Ser Lys Met Met 
            580                 585                 590         


Glu Tyr Leu Tyr Gln Asp Asp Ser Asn Ile Arg Asp Ala Gln Ile Pro 
        595                 600                 605             


Ala Phe Asn Ser Val Ile Lys Arg Lys Asp Met Ala Glu Val Ile Glu 
    610                 615                 620                 


Lys Ile Val Lys Lys Asn Ser Tyr Lys Thr Ile Lys Glu Leu Tyr Gln 
625                 630                 635                 640 


Arg Glu Lys Tyr Arg Ser Cys Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
                645                 650                 655     


Tyr Asn Arg Phe Ile Lys Gln Asp Asn Leu Lys Asp Gln Val Ile Gln 
            660                 665                 670         


Ile Ile Asp Ser Asn Thr Glu Leu Ile Gly Asp Asn Ser Arg Ala Val 
        675                 680                 685             


Asp Asn Leu Lys Lys Arg Ile His Asp Val Asp Ser Gln Thr Met Ser 
    690                 695                 700                 


Phe Gly Glu Leu Cys Gln Val Ile Met Thr Asp Tyr Asn Met Gln Asn 
705                 710                 715                 720 


Gln Glu Asn Lys Ser Ile Lys Ser Lys Glu Arg Gln Asp Lys Asp Arg 
                725                 730                 735     


Lys Asn Gly Ile Asp Asn Ser Tyr Lys His Phe Pro Leu Leu Leu His 
            740                 745                 750         


His Leu Ile Lys Val Ser Phe Leu Lys Phe Ile Lys Thr Asp Glu Lys 
        755                 760                 765             


Leu Ala Phe Ile Arg Glu Pro Arg Ile Thr Glu Leu Asp Lys Thr Leu 
    770                 775                 780                 


Glu Gln Phe Glu Ala Gln Ile Gln Thr Val Asp Ile Tyr Asn Ser Leu 
785                 790                 795                 800 


Lys Met Met Val Ala Glu Asn Lys Ser Leu Leu Asp Trp Tyr Thr Leu 
                805                 810                 815     


Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asp Val 
            820                 825                 830         


Lys Asn Tyr Ile Gln Tyr Leu Ser Asn Ile Asp Lys Arg Ala Gly Ser 
        835                 840                 845             


Val Lys Asn Asn Lys Ser Ala Ser Thr Glu Val Lys Ile Arg Gln Tyr 
    850                 855                 860                 


Ser Glu Ile Val Arg Ile Leu Asp Phe Ser Leu Gln Tyr Ile Gly Arg 
865                 870                 875                 880 


Val Ser Asn Asp Val Thr Asp Tyr Phe Val Asp Glu Asp Glu Tyr Ala 
                885                 890                 895     


Ala Phe Leu Ser Lys Tyr Val Glu Phe Ser Gly Asn Asp Ile Val Ser 
            900                 905                 910         


Met Lys Ala Phe Cys Gln Ser Arg Thr Ala Asn Gly Lys His Thr Ile 
        915                 920                 925             


Gly Leu Tyr Cys Asp Gly Ala Asn Pro Ile Met Asn Arg Asn Ile Ala 
    930                 935                 940                 


Tyr Ala Lys Met Tyr Gly Asn Asp Glu Ile Leu Ser Tyr Ile Tyr Asn 
945                 950                 955                 960 


Lys Val Thr Lys Lys Asp Ile Glu Lys Tyr Tyr Val Ser Gln Asp Asn 
                965                 970                 975     


Leu Glu Lys Val Phe Ala Asp Gly Lys Cys Gln Asp Val Gln Gln Gln 
            980                 985                 990         


Asn Ala Leu Cys Asp Phe Gln Lys  Met Lys Asn His Ile  Glu Leu Thr 
        995                 1000                 1005             


Glu Val  Ser Ile Tyr Thr Asp  Ile Leu Asn Asp Phe  Met Ala Gln 
    1010                 1015                 1020             


Phe Ile  Ser Trp Ala Tyr Leu  Arg Glu Arg Asp Leu  Met Tyr Phe 
    1025                 1030                 1035             


Gln Leu  Gly Leu Asn Tyr Ile  Arg Met Phe Tyr Gly  Thr Tyr Glu 
    1040                 1045                 1050             


Leu Glu  Glu Lys Tyr Tyr Lys  Leu His Gly Glu Asn  Ile Asn Ile 
    1055                 1060                 1065             


Glu Lys  Gly Ala Leu Leu Tyr  Gln Ile Val Ala Met  Tyr Ser His 
    1070                 1075                 1080             


Glu Leu  Pro Ile Tyr Lys Val  Asp Glu Ser Gly Ile  Ala Ile Leu 
    1085                 1090                 1095             


Ala Glu  Lys Gln Gly Ser Ser  Gly Ala Ser Ile Lys  Ser Phe Val 
    1100                 1105                 1110             


Thr Glu  Tyr Cys Lys Glu Glu  Met Lys Lys Ala His  Thr Tyr Glu 
    1115                 1120                 1125             


Asn Gly  Leu Glu Leu Phe Glu  Asp Val Asn Gln His  Asp Asp Leu 
    1130                 1135                 1140             


Ser Lys  Leu Arg Asn Asp Phe  Ala His Met Arg Tyr  Met Ser Ala 
    1145                 1150                 1155             


Arg Asp  Lys Ser Ile Met Asp  Ile Val Ser Glu Ile  Tyr Asn Gly 
    1160                 1165                 1170             


Phe Phe  Ile Tyr Asp Thr Lys  Leu Lys Lys Ser Val  Ser Phe Ile 
    1175                 1180                 1185             


Phe Lys  Asn Ile Leu Met Arg  Tyr Ala Val Asp Val  Asn Ile Glu 
    1190                 1195                 1200             


Phe Cys  His Lys Gly Asp Asn  Glu Asp Thr Asn Asn  Leu Ile Arg 
    1205                 1210                 1215             


Ile Lys  Asp Glu Val Gly Leu  Tyr Ser Asp Lys Tyr  Thr Tyr Lys 
    1220                 1225                 1230             


Val Glu  Asp Asn Asp Thr Val  Asp Ile Glu Val Arg  Asn Ser Glu 
    1235                 1240                 1245             


Phe Leu  Glu Gln Leu Lys Lys  Leu Leu Glu Tyr Lys  Lys Glu Ser 
    1250                 1255                 1260             


Glu Gly  Ser Glu Leu 
    1265             


<210>  528
<211>  1186
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  528

Met Lys Val Thr Lys Ile Asp Gly Leu Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ile Glu Asp Ala Ser Gln Lys Asn Glu Thr 
            20                  25                  30          


Leu Glu Arg Leu Glu Lys Leu Lys Glu Ile Lys Leu Gly Asn Tyr Ile 
        35                  40                  45              


Lys Asn Pro Asp Lys Thr Lys Asp Lys Asp Asn Lys Lys Arg Arg Lys 
    50                  55                  60                  


Gly Leu Lys Glu Tyr Phe Ser Glu Ile Thr Leu Arg Lys Glu Asn Glu 
65                  70                  75                  80  


Lys Tyr Val Leu Leu Lys Gly Lys Lys Leu Lys Lys Ile Asn Asn Asp 
                85                  90                  95      


Ile Lys Asp Thr Asp Ile Lys Val Lys Tyr Lys Lys Glu Glu Val Phe 
            100                 105                 110         


Asp Val Leu Lys Lys Ile Leu Lys Leu Asn Leu Leu Ala Asn Asp Val 
        115                 120                 125             


Glu Glu Lys Ile Gln Phe Asp Ser Ile Lys Leu Lys Asn Val Phe Gly 
    130                 135                 140                 


Lys Asp Phe Val Lys Lys Glu Leu Gln Ile Lys Ser Ile Glu Glu Ser 
145                 150                 155                 160 


Leu Glu Lys Asn Lys Ala Asp Tyr Arg Lys Glu Phe Ile Glu Ile Glu 
                165                 170                 175     


Asn Asp Lys Tyr Gly Asn Val Lys Gly Glu Asn Lys Lys Asn Arg Ile 
            180                 185                 190         


Tyr Glu Tyr Tyr Lys Lys Ser Glu Thr His Glu Lys Phe Arg Lys Asn 
        195                 200                 205             


Ile Ile Glu Ala Phe Glu Lys Leu Tyr Lys Lys Asp Asp Ile Glu Lys 
    210                 215                 220                 


Leu Tyr Thr Gln Ile Ile Glu Ile Ser Lys Lys Met His Leu Lys Ser 
225                 230                 235                 240 


Lys Val Arg Glu Leu Tyr Lys Asn Val Ile Ile Lys Arg Ser Cys Asp 
                245                 250                 255     


Asp Phe Ser Lys Lys Asn Lys Glu Gly Ile Ser Val Leu Tyr Ser Gln 
            260                 265                 270         


Ile Met Asn Ser Val Lys Lys Asn Glu Lys Phe Val Lys Phe Val Lys 
        275                 280                 285             


Asn Ile Glu Leu Lys Asp Leu Thr Lys Ser Gln Ile Phe Tyr Lys Tyr 
    290                 295                 300                 


Phe Leu Glu Asn Glu Glu Leu Asn Asp Glu Asn Ile Lys Asn Ile Phe 
305                 310                 315                 320 


Cys Tyr Phe Val Glu Ile Glu Val Ser Asp Leu Leu Lys Gly Asn Val 
                325                 330                 335     


Tyr Lys Val Ser Lys Ile Tyr Glu Asn Lys Ile Lys Asn Ile Phe Glu 
            340                 345                 350         


Tyr Asn Lys Leu Lys Lys Leu Val Ile Asn Lys Leu Glu Asn Lys Leu 
        355                 360                 365             


Asn Asn Tyr Val Arg Asn Cys Gly Lys Tyr Asn Tyr His Met Glu Asn 
    370                 375                 380                 


Gly Asp Ile Ala Thr Ser Asp Ile Asn Met Arg Asn Arg Gln Thr Glu 
385                 390                 395                 400 


Ala Phe Leu Arg Ser Met Ile Gly Val Ser Ser Phe Gly Tyr Phe Ser 
                405                 410                 415     


Leu Arg Asn Ile Leu Gly Val Asn Asp Asp Asp Phe Tyr Glu Ile Glu 
            420                 425                 430         


Glu Asp Leu Thr Glu Glu Glu Arg Lys Asn Glu Ser Asn Val Leu Lys 
        435                 440                 445             


Lys Ala Lys Glu Asp Ile Thr Ser Lys Ser Ile Phe Glu Lys Val Val 
    450                 455                 460                 


Asp Lys Ser Phe Glu Lys Lys Gly Ile His Ser Ile Arg Glu Asn Val 
465                 470                 475                 480 


Lys Met Phe Tyr Gly Asp Ser Phe Asp Lys Ala Asn Glu Asp Glu Leu 
                485                 490                 495     


Lys Gln Phe Phe Val Asn Met Leu Asn Ala Ile Thr Ser Ile Arg His 
            500                 505                 510         


Arg Val Val His Tyr Asn Met Asn Thr Asn Ser Glu Asn Ile Phe Asn 
        515                 520                 525             


Phe Ser Asp Ile Glu Val Ser Arg Leu Leu Lys Ser Ile Phe Glu Lys 
    530                 535                 540                 


Glu Thr Asp Lys Arg Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn 
545                 550                 555                 560 


Ser Ala Gly Val Phe Asp Tyr Trp Glu Asn Trp Lys Ile Lys Lys Tyr 
                565                 570                 575     


Leu Glu Asn Met Lys Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val 
            580                 585                 590         


Pro Ser Phe Thr Lys Leu Tyr Asn Arg Ile Asp Asn Leu Lys Gly Ser 
        595                 600                 605             


Asn Ala Leu Asn Leu Gly Tyr Ile Asn Ile Pro Lys Arg Lys Glu Ala 
    610                 615                 620                 


Arg Asp Ser Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Lys Phe 
625                 630                 635                 640 


Val Glu Glu Phe Ile Lys Asn Asn Asp Asn Phe Glu Lys Ile Phe Arg 
                645                 650                 655     


Glu Ile Ile Glu Ile Asn Lys Asn Ala Gly Thr Asn Lys Gln Thr Asn 
            660                 665                 670         


Phe Tyr Lys Leu Glu Lys Phe Glu Lys Leu Lys Ala Asn Thr Pro Thr 
        675                 680                 685             


Glu Tyr Leu Glu Lys Leu Gln Ser Leu His Lys Ile Asn Tyr Asn Arg 
    690                 695                 700                 


Glu Lys Ile Glu Glu Asp Lys Asp Ile Tyr Val Asp Phe Val Gln Lys 
705                 710                 715                 720 


Ile Phe Leu Lys Gly Phe Ile Ser Tyr Leu Gln Lys Ser Asn Ser Leu 
                725                 730                 735     


Lys Pro Leu Asn Leu Leu Asn Leu Lys Lys Asp Glu Val Ile Asn Ser 
            740                 745                 750         


Glu Lys Ser Phe Tyr Asp Glu Lys Leu Lys Gln Trp Glu Asn Asn Gly 
        755                 760                 765             


Ser Asn Leu Ser Glu Met Pro Lys Glu Ile Tyr Lys Tyr Ile Lys Glu 
    770                 775                 780                 


Ile Lys Ile Asn Lys Thr Asn Tyr Ser Asp Arg Met Ser Ile Phe Tyr 
785                 790                 795                 800 


Leu Leu Leu Lys Leu Ile Asp His Lys Glu Leu Thr Asn Leu Arg Gly 
                805                 810                 815     


Asn Leu Glu Lys Tyr Glu Ser Met Asn Lys Asn Lys Ile Tyr Ser Glu 
            820                 825                 830         


Glu Leu Asn Ile Val Asn Leu Val Ser Leu Asp Asn Asn Lys Val Arg 
        835                 840                 845             


Thr Asn Phe Ser Val Glu Ala Glu Asp Ile Gly Lys Phe Leu Lys Thr 
    850                 855                 860                 


Glu Thr Ser Ile Lys Asn Ile Asn Gln Leu Asn Asn Phe Ser Gly Ile 
865                 870                 875                 880 


Phe Ala Asp Gly Glu Asn Val Ile Lys His Arg Ser Phe Tyr Asn Ile 
                885                 890                 895     


Lys Lys Tyr Gly Ile Leu Asp Leu Leu Glu Lys Ile Val Ala Lys Ala 
            900                 905                 910         


Asp Leu Lys Ile Ala Lys Glu Glu Ile Lys Lys Tyr Glu Asn Leu Gln 
        915                 920                 925             


Asn Glu Leu Lys Arg Asn Asp Phe Tyr Lys Ile Gln Glu Lys Ile His 
    930                 935                 940                 


Arg Lys Tyr Asn Gln Lys Pro Asn Leu Ile Leu Arg Thr Glu Asn Lys 
945                 950                 955                 960 


Lys Asp Phe Asn Asp Tyr Lys Lys Ala Ile Glu Asn Ile Gln Asn Tyr 
                965                 970                 975     


Thr Gln Leu Lys Asn Lys Ile Glu Phe Asn Asp Leu Asn Leu Leu Gln 
            980                 985                 990         


Gly Leu Leu Phe Arg Ile Leu His  Arg Leu Ala Gly Tyr  Thr Ser Leu 
        995                 1000                 1005             


Trp Glu  Arg Asp Leu Gln Phe  Lys Leu Lys Gly Glu  Phe Pro Glu 
    1010                 1015                 1020             


Asp Lys  Tyr Ile Asp Glu Ile  Phe Asn Ser Asp Arg  Asn Asn Asn 
    1025                 1030                 1035             


Gln Lys  Tyr Lys Ser Gly Gly  Ile Ala Tyr Lys Tyr  Val Asp Phe 
    1040                 1045                 1050             


Leu Ile  Glu Lys Glu Glu Gly  Lys Arg Ala Gly Lys  Asn Lys Val 
    1055                 1060                 1065             


Lys Lys  Arg Ser Glu Lys Glu  Gly Ser Phe Ile Ile  Arg Asn Tyr 
    1070                 1075                 1080             


Ile Ala  His Phe Asn Tyr Ile  Pro Asp Ala Glu Lys  Ser Ile Leu 
    1085                 1090                 1095             


Glu Ile  Leu Glu Glu Leu Arg  Glu Leu Leu Lys Tyr  Asp Arg Lys 
    1100                 1105                 1110             


Leu Lys  Asn Ala Val Met Lys  Ser Val Lys Asp Ile  Phe Lys Glu 
    1115                 1120                 1125             


Tyr Gly  Phe Ile Val Glu Phe  Arg Ile Ser His Glu  Ser Asn Ser 
    1130                 1135                 1140             


Lys Lys  Ile Lys Val Leu Asp  Val Lys Ser Glu Lys  Ile Lys His 
    1145                 1150                 1155             


Leu Lys  Asn Asn Gly Leu Val  Thr Thr Lys Asn Ser  Glu Asp Leu 
    1160                 1165                 1170             


Cys Glu  Leu Val Lys Val Met  Leu Glu Tyr Lys Lys  Ser 
    1175                 1180                 1185     


<210>  529
<211>  1159
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  529

Met Lys Val Thr Lys Val Gly Gly Ile Ser His Lys Lys Tyr Thr Ser 
1               5                   10                  15      


Glu Gly Arg Leu Val Lys Ser Glu Ser Glu Glu Asn Arg Thr Asp Glu 
            20                  25                  30          


Arg Leu Ser Ala Leu Leu Asn Met Arg Leu Asp Met Tyr Ile Lys Asn 
        35                  40                  45              


Pro Ser Ser Thr Glu Thr Lys Glu Asn Gln Lys Arg Ile Gly Lys Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Met Val Tyr Leu Lys Asp Asn Thr Leu 
65                  70                  75                  80  


Ser Leu Lys Asn Gly Lys Lys Glu Asn Ile Asp Arg Glu Tyr Ser Glu 
                85                  90                  95      


Thr Asp Ile Leu Glu Ser Asp Val Arg Asp Lys Lys Asn Phe Ala Val 
            100                 105                 110         


Leu Lys Lys Ile Tyr Leu Asn Glu Asn Val Asn Ser Glu Glu Leu Glu 
        115                 120                 125             


Val Phe Arg Asn Asp Ile Lys Lys Lys Leu Asn Lys Ile Asn Ser Leu 
    130                 135                 140                 


Lys Tyr Ser Phe Glu Lys Asn Lys Ala Asn Tyr Gln Lys Ile Asn Glu 
145                 150                 155                 160 


Asn Asn Ile Glu Lys Val Glu Gly Lys Ser Lys Arg Asn Ile Ile Tyr 
                165                 170                 175     


Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asp Ala Tyr Val Ser Asn Val 
            180                 185                 190         


Lys Glu Ala Phe Asp Lys Leu Tyr Lys Glu Glu Asp Ile Ala Lys Leu 
        195                 200                 205             


Val Leu Glu Ile Glu Asn Leu Thr Lys Leu Glu Lys Tyr Lys Ile Arg 
    210                 215                 220                 


Glu Phe Tyr His Glu Ile Ile Gly Arg Lys Asn Asp Lys Glu Asn Phe 
225                 230                 235                 240 


Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Met Lys Glu 
                245                 250                 255     


Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser Gln Val 
            260                 265                 270         


Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys Asn Ile 
        275                 280                 285             


Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln Leu Leu 
    290                 295                 300                 


Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp Lys Ile 
305                 310                 315                 320 


Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu Asn Lys 
                325                 330                 335     


Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys Tyr Asn 
            340                 345                 350         


Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile Ala Arg 
        355                 360                 365             


Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val Ser Ser 
    370                 375                 380                 


Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn Glu Asn 
385                 390                 395                 400 


Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn Lys Gly 
                405                 410                 415     


Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn Glu Asn 
            420                 425                 430         


Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser Tyr Asp 
        435                 440                 445             


Phe Asn Val Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala Asn Ile 
    450                 455                 460                 


Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe Asn Leu 
465                 470                 475                 480 


Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala Pro Ser 
                485                 490                 495     


Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys Lys Leu 
            500                 505                 510         


Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe Arg Tyr 
        515                 520                 525             


Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg Phe Glu 
    530                 535                 540                 


Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys Leu Tyr 
545                 550                 555                 560 


Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp Lys Thr 
                565                 570                 575     


Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp Ala Gln 
            580                 585                 590         


Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn Tyr Phe 
        595                 600                 605             


Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile Ile Glu 
    610                 615                 620                 


Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr Lys Leu 
625                 630                 635                 640 


Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr Leu Ala 
                645                 650                 655     


Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp Glu Glu 
            660                 665                 670         


Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu Lys Gly 
        675                 680                 685             


Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile Tyr Ile 
    690                 695                 700                 


Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys Gln Glu 
705                 710                 715                 720 


Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile Glu Ile 
                725                 730                 735     


Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly Asn Ile 
            740                 745                 750         


Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu Lys Leu 
        755                 760                 765             


Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu Lys Tyr 
    770                 775                 780                 


Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu Leu Ile 
785                 790                 795                 800 


Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe Glu Leu 
                805                 810                 815     


Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn Lys Ile 
            820                 825                 830         


Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile Tyr Phe 
        835                 840                 845             


Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile Lys Lys 
    850                 855                 860                 


Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala Lys Tyr 
865                 870                 875                 880 


Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys Asn Glu 
                885                 890                 895     


Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys Tyr Ala 
            900                 905                 910         


Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Lys Glu Tyr 
        915                 920                 925             


Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys Asn Lys 
    930                 935                 940                 


Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu Lys Ile 
945                 950                 955                 960 


Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp Leu Arg 
                965                 970                 975     


Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu Glu Ile 
            980                 985                 990         


Phe Asn Phe Asp Asn Ser Lys Asn  Val Lys Tyr Lys Ser  Gly Gln Ile 
        995                 1000                 1005             


Val Glu  Lys Tyr Ile Asn Phe  Tyr Lys Glu Leu Tyr  Lys Asp Asn 
    1010                 1015                 1020             


Val Glu  Lys Arg Ser Ile Tyr  Ser Asp Lys Lys Val  Lys Lys Leu 
    1025                 1030                 1035             


Lys Gln  Glu Lys Lys Asp Leu  Tyr Ile Arg Asn Tyr  Ile Ala His 
    1040                 1045                 1050             


Phe Asn  Tyr Ile Pro His Ala  Glu Ile Ser Leu Leu  Glu Val Leu 
    1055                 1060                 1065             


Glu Asn  Leu Arg Lys Leu Leu  Ser Tyr Asp Arg Lys  Leu Lys Asn 
    1070                 1075                 1080             


Ala Val  Met Lys Ser Val Val  Asp Ile Leu Lys Glu  Tyr Gly Phe 
    1085                 1090                 1095             


Val Ala  Thr Phe Lys Ile Gly  Ala Asp Lys Lys Ile  Gly Ile Gln 
    1100                 1105                 1110             


Thr Leu  Glu Ser Glu Lys Ile  Val His Leu Lys Asn  Leu Lys Lys 
    1115                 1120                 1125             


Lys Lys  Leu Met Thr Asp Arg  Asn Ser Glu Glu Leu  Cys Lys Leu 
    1130                 1135                 1140             


Val Lys  Val Met Phe Glu Tyr  Lys Met Glu Glu Lys  Lys Ser Glu 
    1145                 1150                 1155             


Asn 
    


<210>  530
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  530

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Thr Glu Asn Lys Asn Glu Glu Gln Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Leu Lys Lys Asn Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Ser Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Cys Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Thr Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Ile Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Gln Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Lys 
                405                 410                 415     


Arg Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Ile Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Ala Leu Glu Gly Glu Ser 
    450                 455                 460                 


Val Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Glu Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Ala Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Lys Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Lys Asp Asp Glu Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Ser Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Lys Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Ala Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Val Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Glu Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Lys Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  531
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  531

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Pro Gly Thr Asp Thr 
            20                  25                  30          


Ile Gly Leu Lys Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Asp Lys Pro Lys Lys 
    50                  55                  60                  


Trp Lys Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Glu Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Ser Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Met Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Tyr Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ser Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Lys Asp Arg Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Lys Glu Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Gln Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Phe 
            660                 665                 670         


Ile Arg Lys Asn Phe Pro Glu Asp Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Asp Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Asp Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asn  Ser Glu Lys Lys Glu  Ala Tyr Gln Lys Ile  Glu Val Asn 
    1100                 1105                 1110             


Gly Asp  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Val  Tyr Ala Pro Asp Glu  Lys Gly Asp 
    1130                 1135                 1140             


Ile Leu  Lys Glu Gln Cys Thr  Lys Gly Gly Ala Gly  Gly Lys Ile 
    1145                 1150                 1155             


Ser Ala  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Lys Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Lys Gln 
    1250                 1255                 1260             


Thr Thr  Ser Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Ser Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Lys  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Val Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Gly Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Pro Asn 
    1370                 1375                 1380         


<210>  532
<211>  1330
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  532

Met Lys Arg Glu Glu Asn Ile Thr Ile Met Lys Ile Ser Lys Val Asn 
1               5                   10                  15      


His Arg Arg Thr Ala Val Ala Leu Asn Gly Asp Lys Ser Glu Leu Gly 
            20                  25                  30          


Gly Ile Leu Tyr Glu Ala Pro Val Gln Lys Asp Lys Asn Gly Asn Tyr 
        35                  40                  45              


Asn Asp Val Ile Ala Glu Thr Gly Lys Val Val Asn Glu Ala Leu Asp 
    50                  55                  60                  


Lys Lys Ser Arg Leu Tyr Thr Pro Phe Asn Asn Gln Lys Val Ile Ile 
65                  70                  75                  80  


Asp Lys Asn Leu Gln Arg Tyr Ala Asn Asn Leu Lys Arg Cys Tyr Ile 
                85                  90                  95      


Asn Phe Val Lys Gln Tyr Val Asn Asn Lys Ser Phe Asn Tyr Lys Ala 
            100                 105                 110         


Met Gln Phe Ile Pro Asp Ile Gln Asn Pro Lys Thr Asn Asp Glu Val 
        115                 120                 125             


Asn Tyr Arg Thr Asp Arg Asp Asn Val Tyr Asn Lys Asn Lys Tyr Tyr 
    130                 135                 140                 


Asp Lys Gln Thr Lys Ser Lys Ser Lys Lys Phe Ile Tyr Glu Lys Ile 
145                 150                 155                 160 


Val Ile Pro Gln Asn Glu Gln Asn Ile Val Ile Ser Ala Leu Val Asn 
                165                 170                 175     


Cys Ser Leu Arg Lys Ser Leu Arg Lys Asp Val Ser Tyr Lys Thr Lys 
            180                 185                 190         


Ser Gly Glu Ile Lys Thr Tyr Asn Leu Pro Glu Leu Val Lys Lys Ser 
        195                 200                 205             


Met Arg Phe Tyr Cys Leu Glu Gly Gln Arg Glu Pro Asp Glu Lys Glu 
    210                 215                 220                 


Lys Tyr Glu Met Tyr Ile Leu Phe Ser Tyr Met Lys Glu Asp Lys Arg 
225                 230                 235                 240 


Thr Lys Asn Thr Asp Leu Leu Val Lys Ser Ile Ser Asn Gln Asn Thr 
                245                 250                 255     


Lys Val Lys Val Glu Asp Ile Asp Gly Asn Lys Leu Leu Lys Leu Ser 
            260                 265                 270         


Ile Ala Asp Thr Lys Lys Lys Pro Leu Trp Glu Tyr Leu Ile Lys Tyr 
        275                 280                 285             


Ala Asp Ser Ser Arg Gln Arg Glu Leu Met Tyr Asp Ile Arg Lys Lys 
    290                 295                 300                 


Ile Ile Leu Tyr Val Ala Gly Ile Glu Glu Tyr Glu Asn Ile Lys Glu 
305                 310                 315                 320 


Asp Ser Gly Leu Ser Lys Val Ser Trp Ser Lys Tyr Asn Ile Ser Asp 
                325                 330                 335     


Asn Lys Met Phe Phe Asp Ile Asn Ser Cys Thr Asp Lys Arg Lys Gln 
            340                 345                 350         


Asn Leu Glu Ile Lys Ile Arg Glu Ala Asn Ile Glu His Tyr Arg Asn 
        355                 360                 365             


Ala Ser Ser Lys Leu Cys Asp Asp Glu Ser Ile Phe Trp Phe Gln His 
    370                 375                 380                 


Phe Glu Gly Val Ile Glu Thr Leu Phe Ser Lys Lys Ser Lys Ile Ser 
385                 390                 395                 400 


Glu Glu Arg Leu Gly Cys Ala Tyr Ile Cys Asp Tyr Leu Trp Lys Asp 
                405                 410                 415     


Phe Leu Ser Tyr Leu Ala Ala Lys Tyr Ile Asp Leu Gly Lys Gly Val 
            420                 425                 430         


Tyr His Phe Thr Met Lys Asp Lys Leu Asp Met Leu Asn Lys Asn Glu 
        435                 440                 445             


Ala Val Thr Asp Leu Arg Phe Gly Ile Val Ser Glu Lys Tyr Glu Lys 
    450                 455                 460                 


Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Glu Leu 
465                 470                 475                 480 


Asp Arg Asn Ile Ala Ala Tyr Val Thr Phe Ala Ala Asp Ile Phe Ala 
                485                 490                 495     


Lys Ser Val Ile Lys Ser Asp Tyr Arg Thr Lys Lys Asp Asn Asn Ser 
            500                 505                 510         


Asp Val Leu Gln Tyr Ser Asp Lys Glu Phe Arg Asn Ser Glu Val Ile 
        515                 520                 525             


Arg Asp Asn Ala Glu Lys Asn Ile Leu Gln Tyr Trp Gly Gly Tyr Ser 
    530                 535                 540                 


Arg Trp Gly Thr Glu Asn Ser Lys Leu Pro Glu Asn Asn Lys Val Ser 
545                 550                 555                 560 


Asp Phe Gly Lys Leu Asn Val Ser Asp Leu Cys Ile Asp Ile Lys Lys 
                565                 570                 575     


His Leu Ala Gly Ile Arg Asn Ser Ser Val His Tyr Thr Thr Lys Ile 
            580                 585                 590         


Lys Asn Glu Ser Ala Ala Asp Gly Ser Asn Val Lys Ile Leu Phe Glu 
        595                 600                 605             


Lys Asp Leu Ala Asp Ile Asn Ile Ile Tyr Ala Asp Lys Tyr Tyr Ser 
    610                 615                 620                 


Asn Asn Val Trp Met Phe Tyr Ser Leu Glu Asp Ile Asn Lys Leu Ile 
625                 630                 635                 640 


Ala Phe Leu Tyr Lys Glu Lys Arg Val Ile Arg Gln Val Gln Ile Pro 
                645                 650                 655     


Ser Phe Ser Arg Ile Leu Lys Arg Lys Ala Met Gln Asp Val Ile Asn 
            660                 665                 670         


Glu Ile Phe Lys Asp Asp Phe Asp Glu Asn Ile Val Asn Pro Glu Leu 
        675                 680                 685             


Lys Glu Lys Tyr Arg Asn Ser Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
    690                 695                 700                 


Tyr Asn Ala Phe Ile Ile Gln Pro Glu Leu Lys Glu Lys Phe Lys Asp 
705                 710                 715                 720 


Lys Ile Lys Thr Met Lys Ser Glu Leu Tyr Asn Lys Leu Lys Thr Ile 
                725                 730                 735     


Asp Lys Lys Glu Tyr Lys Ala Leu Tyr Cys Met Leu Ser Asn Glu Glu 
            740                 745                 750         


Ser Ala Leu Lys Asn Phe Ala Asp Arg Ile Tyr Ser Val Asp Gly Asp 
        755                 760                 765             


Asn Val Ser Phe Ala Asp Ile Cys Lys Ile Leu Met Thr Asp Tyr Asn 
    770                 775                 780                 


Met Gln Asn Gln Glu Lys Lys Asn Ile Glu Ser Met Glu Gln Lys Lys 
785                 790                 795                 800 


Lys Asn Lys Gly Lys Asp Glu Asn Tyr Lys His Phe Pro Leu Leu Leu 
                805                 810                 815     


His Lys Val Leu Lys Glu Leu Phe Ile Glu Tyr Leu Lys Gln Thr His 
            820                 825                 830         


Glu Leu Glu Phe Leu Arg Asn Asn Ile Cys Ile Lys Ser Asp Val Thr 
        835                 840                 845             


Met Glu Ser Phe Glu Ser Gln Ile Lys Gly Val Glu Ile Tyr Lys Asp 
    850                 855                 860                 


Leu Lys Glu Lys Ile Asp Lys Asn Asn Ser Leu Leu Asp Trp Tyr Val 
865                 870                 875                 880 


Ile Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asn 
                885                 890                 895     


Ile Lys Asn Tyr Ile Gln Phe Ala Thr Asn Ile Asp Lys Arg Ala Glu 
            900                 905                 910         


Ser Val Lys Asn Leu Thr Glu Ser Gly Met Val Lys Arg Ile Gln Tyr 
        915                 920                 925             


Tyr Asp Asp Ile Val Arg Thr Leu Glu Phe Ser Ala Gln Tyr Ile Gly 
    930                 935                 940                 


Lys Ile Ser Asn Asn Ile Asn Asp Tyr Phe Asn Ser Glu Asp Glu Tyr 
945                 950                 955                 960 


Val Ser Phe Leu Ser Lys Tyr Val Gly Phe Ile Asn Asp Lys Ser Glu 
                965                 970                 975     


Asp Val Leu Thr Glu Leu Lys Asp Phe Cys Arg Glu Lys Ile Asn Asn 
            980                 985                 990         


Gly Ser Gln Ile Ile Gly Ile Tyr  Tyr Gly Gly Asp Asn  Val Ile Ile 
        995                 1000                 1005             


Asn Arg  Asn Val Ile Tyr Ala  Gln Met Tyr Ser Asn  Ala Glu Val 
    1010                 1015                 1020             


Phe Ser  Asn Ile Tyr Lys Lys  Val Thr Lys Asn Asp  Ile Ile Asn 
    1025                 1030                 1035             


Tyr Tyr  Glu Lys Gln Asn Asp  Leu Lys Asp Val Phe  Lys Ser Gly 
    1040                 1045                 1050             


Val Cys  Gln Asn Glu Gly Glu  Gln Arg Ser Leu Cys  Glu Phe Gln 
    1055                 1060                 1065             


Gln Leu  Lys Asn Arg Thr Glu  Leu Thr Glu Leu Ser  Thr Tyr Ala 
    1070                 1075                 1080             


Asp Met  Val Asn Asp Phe Met  Ala Gln Phe Val Glu  Trp Ala Tyr 
    1085                 1090                 1095             


Leu Arg  Glu Arg Asp Leu Met  Tyr Phe Gln Leu Gly  Ile His Tyr 
    1100                 1105                 1110             


Ile Arg  Leu Phe Tyr Ser Asp  Asn Ala Leu Asp Glu  Lys Tyr His 
    1115                 1120                 1125             


Lys Leu  Ser Asp Asn Val Ile  Asp Ile Glu Glu Gly  Ala Leu Leu 
    1130                 1135                 1140             


Tyr Gln  Ile Val Ala Met Tyr  Asp Tyr Glu Leu Arg  Ile Phe Glu 
    1145                 1150                 1155             


Thr Asp  Asn Ser Gly Asn Ala  Lys Arg Ile Gly Gln  Gly Gly Pro 
    1160                 1165                 1170             


Gly Lys  Ser Ile Pro Val Phe  Leu Lys Lys Tyr Cys  Asn Gly Thr 
    1175                 1180                 1185             


Asp Val  Tyr Glu Cys Gly Leu  Glu Leu Phe Glu Asp  Ile Asn Gln 
    1190                 1195                 1200             


His Glu  His Ile Ile Arg Phe  Arg Asn Asp Ile Ala  His Met Arg 
    1205                 1210                 1215             


Tyr Met  Ser Asn Gln Ala Met  Asn Ile Met Ser Ile  Val Ser Asn 
    1220                 1225                 1230             


Ile Tyr  Lys Ser Phe Phe Val  Tyr Asp Thr Lys Leu  Lys Lys Ser 
    1235                 1240                 1245             


Ile Ser  Leu Val Phe Lys Asn  Ile Leu Met Arg Tyr  Gly Val Ile 
    1250                 1255                 1260             


Ala Asp  Leu Val Phe Ser Tyr  Asn Asn Lys Asn Gln  Ser Ile Lys 
    1265                 1270                 1275             


Asp Asp  Met Asp Ile Asn Ile  Ile Asn Ile Lys Asn  Leu Lys Ser 
    1280                 1285                 1290             


Asp Lys  Tyr Val Tyr Lys Ile  Val Asn Glu Asp Ile  Val Lys Gln 
    1295                 1300                 1305             


Val Glu  Ile Glu Ile Arg Asn  Gln Val Phe Leu Glu  Gln Leu His 
    1310                 1315                 1320             


Asn Leu  Leu Tyr Phe Ser Arg  
    1325                 1330 


<210>  533
<211>  1183
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  533

Met Pro Ile Val Lys Lys Phe Gly Arg Ser Gln Thr Ser Leu Ser Asp 
1               5                   10                  15      


Arg Lys Ile Val Leu Lys Met Glu Thr Ala Ala Arg Asn Ile Pro Asp 
            20                  25                  30          


Phe Leu Leu Ser Asp Pro Glu Ala Val Ile Gly Gln Trp Ala Ser Ala 
        35                  40                  45              


Met Asp Lys Ile Ala Lys Lys Pro Lys Gly Lys Asp Lys Pro Ser Ser 
    50                  55                  60                  


Tyr Gln Arg Lys Phe Arg Glu Arg Leu Gly Lys Ala Ile Trp Ala Asp 
65                  70                  75                  80  


Leu Thr Gly Pro Glu Gly Pro Leu Arg Asp Val Pro Ala Ala Glu Leu 
                85                  90                  95      


Glu Asp Leu Arg Lys Arg Trp Asp Arg Arg Val His Pro Tyr Pro Asp 
            100                 105                 110         


Gly Thr Lys Asp Gly Pro Lys Pro Ala Thr Pro Lys Gly Arg Leu Tyr 
        115                 120                 125             


Thr Arg Phe Ala Gly Glu Val Gly Tyr Gly Lys Ala Asp Ala Val Ala 
    130                 135                 140                 


Ile Ala Arg Asp Ile Arg Ile His Leu Leu Glu Thr Glu Phe Lys Thr 
145                 150                 155                 160 


Gly Gly Gly Thr Arg Asp Ala Gly Arg Ala Val Arg Arg Ala Ser Ser 
                165                 170                 175     


Ile Glu Lys Asn Val Leu Lys Lys Ala Arg Val Pro Gln Arg Pro Lys 
            180                 185                 190         


Pro Pro Gln Glu Ala Ala Trp Ser Lys Glu Asp Glu Asp Arg Tyr Phe 
        195                 200                 205             


Ile Pro His Asp Val Ala Arg Lys Ile Val Leu Ala Ala Lys Ala Gln 
    210                 215                 220                 


Glu Lys Glu Asp His Arg Val Ala Trp Arg Thr Ala Ala Ala Val Leu 
225                 230                 235                 240 


Phe Glu His Phe Gly Arg Ile Phe Gln Gln Asp Gly Arg Ala Leu Ser 
                245                 250                 255     


Phe Ala Glu Ala Glu Lys Gln Met Pro Gly Leu Leu Ala Leu His Arg 
            260                 265                 270         


Ala Val Glu Gly Tyr Tyr Arg Gln Ala Leu Lys Arg His Arg Lys Asp 
        275                 280                 285             


Arg Arg Glu His Glu Ala Arg Pro Gly Arg Glu Lys Gly Thr Gly Arg 
    290                 295                 300                 


Arg Lys Val Ser Ala Ile Leu Pro Lys Asp Lys Thr Ala Leu Leu Ala 
305                 310                 315                 320 


Leu Ile Gly His Gln His Gln Asn Arg Glu Ile Ala Ala Leu Ile Arg 
                325                 330                 335     


Leu Gly Arg Ile Leu His Tyr Glu Ala Gly Arg Arg Gly Asn Ser Asp 
            340                 345                 350         


Met Val Ala Asn Ile Asn Arg Asn Trp Pro Ala Asp Val Ser Glu Ser 
        355                 360                 365             


His Tyr Trp Thr Ser Ala Gly Gln Ile Glu Ile Lys Arg Asn Glu Ala 
    370                 375                 380                 


Phe Val Arg Ile Trp Arg Ser Ala Leu Ser His Ala Asn Arg Thr Leu 
385                 390                 395                 400 


Gly Asp Trp Leu Ser Pro Asp Glu Val Ala Asn Asp Ile Thr Met Ser 
                405                 410                 415     


Trp Glu Ser Lys His Glu Lys Ser Gly Lys Arg Lys Thr Gly Lys Leu 
            420                 425                 430         


Glu Glu Asn Arg Glu Glu Ala Glu Ala His Ala Pro Val Ile Phe Gly 
        435                 440                 445             


Gly Ser Ala Glu Arg Leu Gly Thr Gly Asp Asp Phe Gln Lys Thr Leu 
    450                 455                 460                 


Glu Ala Ile Cys Glu Val Phe Ser Gln Leu Arg His Ser Ser Phe His 
465                 470                 475                 480 


Phe Arg Gly Leu Asp Gly Phe Lys Asp Ala Leu Thr Lys Thr Val Lys 
                485                 490                 495     


Thr Cys Asp Pro Gly Ala Val Ala Arg Leu Gln Asp Leu His Ala Glu 
            500                 505                 510         


Asp Gln Ala Asn Arg Glu Ala Arg Leu Lys Glu Asp Leu Arg Gly Ala 
        515                 520                 525             


His Ala Glu Leu Phe Leu Asp Glu Gly Arg Leu Ala Glu Ile Trp Ala 
    530                 535                 540                 


Leu Leu His Pro Lys Ser Thr Glu Lys Thr Leu Pro Pro Leu Pro Arg 
545                 550                 555                 560 


Tyr Ser Arg Val Val Thr Arg Ala Glu Asn Thr Cys Asn Gly Leu Lys 
                565                 570                 575     


Leu Pro Lys Ser Val Asn Arg Glu Ser Met Lys Val Pro Ala Ile His 
            580                 585                 590         


Cys Arg Tyr Ile Leu Thr Arg Leu Leu Tyr Gln Ser Gly Phe Arg Thr 
        595                 600                 605             


Trp Ile Ala Glu Ala Pro Ala Ala Gln Leu Asn Arg Trp Ile Glu Thr 
    610                 615                 620                 


Ala Thr Glu Arg Ala Gln Lys Ala Thr Val Gly Ile Thr Lys Asn Glu 
625                 630                 635                 640 


Ala Asp Arg Ala Arg Met Val Gly Gln Ile Lys Val Pro Glu Gly Gln 
                645                 650                 655     


Gly Ile Arg Arg Phe Leu Asp Asp Leu Ala Gly Leu Thr Ala Thr Glu 
            660                 665                 670         


Phe Arg Val Gln Ala Gly Tyr Glu Ser Asp Arg Glu Ala Ala Arg Asp 
        675                 680                 685             


Gln Ala Ala Phe Leu Glu Asn Leu Asn Cys Asp Val Met Ala Leu Ala 
    690                 695                 700                 


Phe Asp Lys Tyr Leu Ser Asp His Lys Leu Gly Trp Leu Ala Gly Ile 
705                 710                 715                 720 


Asp Ala Glu Ser Arg Pro Ser Glu Thr Pro Leu Ser Asn Val Asp Glu 
                725                 730                 735     


Leu Pro Ser Ser Gly Ser Leu Gly Thr Pro Glu Arg Trp Glu Ala Ala 
            740                 745                 750         


Leu Tyr Ala Val Cys His Leu Ile Pro Val Ser Glu Val Gly Arg Leu 
        755                 760                 765             


Leu His Gln Leu Arg Arg Trp Ser Asn Gly Gln Lys Ala Thr Pro Asp 
    770                 775                 780                 


Gly Gly Arg Leu Glu Arg Leu Phe Glu Leu Tyr Leu Asp Met His Asp 
785                 790                 795                 800 


Ala Lys Phe Asp Gly Ser Thr Pro Leu Arg Asp His Asp Asp Leu Ala 
                805                 810                 815     


Val Ile Phe Glu Thr Thr Gly Ile Arg Asp Arg Val Leu Pro Ser Ser 
            820                 825                 830         


Leu Gln His Gly Glu His Glu Arg Leu Pro Leu Arg Gly Leu Arg Glu 
        835                 840                 845             


Met Leu Arg Phe Gly Asn Leu Arg Val Leu Ala Pro Ile Phe Ala Thr 
    850                 855                 860                 


Ala Lys Val Asp Gln Ala Met Ile Gly Glu Leu Glu Gly Leu Glu Ala 
865                 870                 875                 880 


Arg Ile Gly Asp Ala Pro Ser Gln Val Asp Arg Ala Gln Ala Leu Arg 
                885                 890                 895     


Thr Glu Met His Ala Ala Leu Cys Lys Lys Arg Lys Leu Ala His Asp 
            900                 905                 910         


Asp Lys Lys Ser Val Lys Asp Tyr Leu Thr Ser Leu Gln Thr Val Ile 
        915                 920                 925             


Arg His Arg Arg Leu Ala Asn His Val Arg Leu Thr Asn His Val Arg 
    930                 935                 940                 


Thr Asn Glu Ile Leu Met Ser Val Met Gly Arg Leu Ala Asp Phe Ser 
945                 950                 955                 960 


Gly Ile Trp Glu Arg Asp Leu Tyr Phe Val Thr Asn Ala Leu Leu Tyr 
                965                 970                 975     


Gln Ala Gly Leu Thr Pro Cys Asp Val Phe Ser Lys Glu Pro Pro Lys 
            980                 985                 990         


Glu Asn Arg Arg Ser Pro Leu Gln  Glu Phe Glu Asn Gly  Gln Ile Val 
        995                 1000                 1005             


Phe Ala  Leu Arg Lys Met Gln  Ala Gln Cys Asp Thr  His Ala Gly 
    1010                 1015                 1020             


Leu Val  Asp Gln Ile Lys Gly  Glu Thr Ala Arg Leu  Phe His Ile 
    1025                 1030                 1035             


Ala Glu  Gly Ala Pro Gly Asn  Asp Pro Arg Ile Gln  Asn Arg Asn 
    1040                 1045                 1050             


Trp Phe  Ala His Phe Asn Ala  Leu Lys Pro Lys Thr  Gly Asp Arg 
    1055                 1060                 1065             


Leu Asp  Leu Thr Ala Asp Met  Asn Arg Ala Arg Asp  Leu Met Ala 
    1070                 1075                 1080             


Tyr Asp  Arg Lys Leu Lys Asn  Ala Val Val Ser Ala  Ile Val Thr 
    1085                 1090                 1095             


Leu Leu  Glu Arg Glu Asn Ile  Val Ile Ala Trp Thr  Met Lys Asp 
    1100                 1105                 1110             


His Gln  Leu Thr Asp Ala Val  Leu Ala Ala Lys Ser  Ile Glu His 
    1115                 1120                 1125             


Leu Lys  Gln Asn Lys Ile Arg  Glu Asn Leu Arg Asp  Glu Arg Ser 
    1130                 1135                 1140             


Leu Gly  Tyr Val Ala Ala Leu  Phe Gly Gly Arg Val  Ala Glu Glu 
    1145                 1150                 1155             


Ala Pro  Asp Ile Met His Asp  Arg Thr Val Phe His  Leu Val Gly 
    1160                 1165                 1170             


Ala Leu  Thr Glu Glu Met Glu  Pro Ala Glu 
    1175                 1180             


<210>  534
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  534

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  535
<211>  1380
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  535

Met Gly Asn Leu Phe Gly His Lys Arg Trp Tyr Glu Val Ser Asp Arg 
1               5                   10                  15      


Gly Asp Asn Lys Ile Lys Arg Lys Val Lys Val Lys Arg Asn Tyr Asp 
            20                  25                  30          


Gly Asn Lys Tyr Ile Leu Asn Ile Asn Glu Asn Asn Asn Lys Glu Lys 
        35                  40                  45              


Ile Asp Asn Asn Lys Phe Ile Arg Glu Phe Val Asn Tyr Lys Lys Asn 
    50                  55                  60                  


Asp Asn Ile Leu Arg Glu Phe Lys Arg Lys Phe His Ala Gly Asn Ile 
65                  70                  75                  80  


Leu Phe Lys Leu Lys Gly Asn Lys Arg Ser Ile Glu Asp Ser Asn Gly 
                85                  90                  95      


Phe Leu Lys Thr Glu Glu Ile Ile Leu Asp Lys Glu Val Tyr Gly Gln 
            100                 105                 110         


Ser Glu Lys Leu Arg Asn Glu Lys Gly Ile Thr Lys Gln Asp Ile Leu 
        115                 120                 125             


Lys Glu Ile Ile Asp Lys Gly Ile Asp Lys Ser Asn Asp Lys Ile Leu 
    130                 135                 140                 


Val Lys Thr Lys Phe Gly Lys Glu Ile Thr Ile Asn Phe Thr Asp Glu 
145                 150                 155                 160 


Asp Lys Lys Asn Lys Asn Lys Tyr Gln Ile Thr Leu Lys Ile Ile Pro 
                165                 170                 175     


Glu Asn Glu Leu Lys Ile Lys Arg Glu Val Tyr Asn Val Phe Lys Ile 
            180                 185                 190         


Ile Asn Ile Asn Leu Tyr Gln Ile Ile Lys Gly Ile Ile Glu Asn Lys 
        195                 200                 205             


Glu Ile Phe Lys Asn Arg Tyr Tyr Asp Glu Ile Leu Lys Glu Lys Leu 
    210                 215                 220                 


Ser Lys Asn Asn Gln Ile Ile Asn Thr Leu Thr Asn Leu Asn Lys Ile 
225                 230                 235                 240 


Arg Lys Glu Ile Arg Asp Asn Arg Asp Asn Ile Ile Gly Phe Val Lys 
                245                 250                 255     


Phe Tyr Leu Asn Val Ser Gly Asp Lys Lys Lys Ser Glu Asn Lys Lys 
            260                 265                 270         


Met Phe Val Glu Lys Ile Leu Asn Thr Asn Val Asp Leu Thr Val Glu 
        275                 280                 285             


Asp Val Val Asp Phe Ile Val Lys Glu Leu Lys Phe Trp Asn Ile Thr 
    290                 295                 300                 


Lys Arg Ile Glu Lys Val Lys Glu Phe Asn Asn Glu Phe Leu Glu Asn 
305                 310                 315                 320 


Lys Arg Asn Arg Thr Tyr Ile Lys Ser Tyr Val Ser Leu Asp Lys His 
                325                 330                 335     


Glu Lys Phe Lys Arg Asp Arg Glu Asn Lys Lys Asp Lys Ile Val Lys 
            340                 345                 350         


Leu Phe Val Lys Asp Ile His Asn Asn Thr Met Glu Glu Lys Ile Asn 
        355                 360                 365             


Gln Ile Leu Asn Lys Phe Lys Ile Lys Glu Leu Ile Glu Lys Leu Lys 
    370                 375                 380                 


Glu Asn Thr Glu Asn Lys Asn Phe Asp Thr Glu Ile Phe Gly Ile Phe 
385                 390                 395                 400 


Lys Thr His Tyr Gln Asn Ile Phe Ser Ser Glu Lys Phe Ser Asn Lys 
                405                 410                 415     


Ser Asp Glu Glu Lys Glu Leu Tyr Lys Ile Ile Tyr Arg Tyr Leu Lys 
            420                 425                 430         


Gly Arg Ile Glu Lys Ile Leu Ile Asn Glu Glu Lys Val Arg Leu Lys 
        435                 440                 445             


Lys Met Glu Lys Ile Glu Ile Glu Lys Ile Leu Asn Glu Ser Ile Leu 
    450                 455                 460                 


Ser Glu Lys Ile Leu Lys Arg Val Lys Gln Tyr Thr Leu Glu His Thr 
465                 470                 475                 480 


Met Tyr Leu Gly Lys Leu Ile His Asn Lys Ile Asn Met Ala Thr Val 
                485                 490                 495     


Asn Thr Asn Asp Phe Ser Arg Leu His Ala Lys Glu Glu Leu Asp Leu 
            500                 505                 510         


Glu Leu Ile Thr Phe Phe Ala Ser Thr Asn Met Glu Leu Asn Lys Ile 
        515                 520                 525             


Phe Asn Gly Lys Glu Lys Ile Thr Asp Phe Phe Gly Phe Asn Leu Asn 
    530                 535                 540                 


Gly Gln Lys Ile Thr Leu Lys Glu Lys Val Pro Asn Phe Lys Leu Asn 
545                 550                 555                 560 


Ile Leu Lys Lys Leu Asn Phe Ile Asn Asn Glu Asn Asn Ile Asp Glu 
                565                 570                 575     


Lys Leu Ser His Phe Tyr Ser Phe Gln Lys Glu Gly Tyr Leu Leu Arg 
            580                 585                 590         


Asn Arg Ile Leu His Asn Ser Tyr Gly Asn Ile Gln Glu Thr Lys Asn 
        595                 600                 605             


Leu Glu Gly Glu Tyr Lys Asn Val Glu Ile Leu Ile Lys Glu Leu Lys 
    610                 615                 620                 


Val Ser Asn Glu Glu Ile Ser Lys Ser Leu Asn Leu Asp Ile Ile Phe 
625                 630                 635                 640 


Glu Gly Lys Val Asp Ile Ile Asn Lys Ile Asn Ser Leu Glu Ile Gly 
                645                 650                 655     


Glu Cys Lys Asp Lys Lys Tyr Leu Pro Ser Phe Ser Lys Ile Val Pro 
            660                 665                 670         


Glu Ile Thr Arg Lys Phe Arg Glu Ile Asn Lys Asp Lys Ser Phe Asp 
        675                 680                 685             


Ile Glu Ser Glu Lys Ile Ile Leu Asn Ala Val Arg Tyr Val Asn Lys 
    690                 695                 700                 


Ile Leu Tyr Glu Lys Ile Thr Ser Asn Glu Glu Asn Glu Phe Ile Lys 
705                 710                 715                 720 


Thr Leu Pro Asp Lys Leu Val Lys Lys Asn Asn Asn Lys Glu Asn Asn 
                725                 730                 735     


Asn Ser Leu Ser Ile Glu Glu Tyr Tyr Lys Asn Ala Gln Ile Ser Ser 
            740                 745                 750         


Ser Lys Gly Asp Lys Lys Ala Ile Lys Lys Tyr Gln Asn Lys Val Thr 
        755                 760                 765             


Asn Ala Tyr Ile Glu Tyr Leu Glu Asn Thr Phe Ala Glu Val Ile Asp 
    770                 775                 780                 


Phe Ser Asn Phe Asn Leu Asn Phe Asp Glu Ile Lys Thr Lys Ile Glu 
785                 790                 795                 800 


Glu Arg Lys Tyr Ser Lys Ser Lys Ile Thr Val Asp Ser Ile Ser Thr 
                805                 810                 815     


Asn Ile Asn Ile Thr Asn Asp Ile Glu Tyr Ile Ile Ser Ile Phe Ala 
            820                 825                 830         


Leu Leu Asn Ser Asn Thr Tyr Ile Asn Lys Ile Arg Asn Arg Phe Phe 
        835                 840                 845             


Ala Thr Ser Val Trp Leu Asp Lys Gln Asn Ser Thr Lys Glu Tyr Asp 
    850                 855                 860                 


Tyr Glu Asn Ile Ile Asp Ile Leu Asp Lys Ile Leu Ser Ile Asn Leu 
865                 870                 875                 880 


Leu Arg Glu Asn Asn Ile Ala Asp Ile Leu Asp Leu Lys Asn Thr Ile 
                885                 890                 895     


Ile Glu Ala Lys Ile Val Glu Asn Asn Glu Glu Cys Ile Lys Asn Tyr 
            900                 905                 910         


Ile Phe Glu Asn Asn Glu Glu Glu Leu Lys Lys Arg Leu Phe Cys Glu 
        915                 920                 925             


Glu Leu Val Asn Lys Glu Glu Val Leu Lys Ile Phe Glu Asp Lys Asn 
    930                 935                 940                 


Phe Lys Phe Lys Asn Phe Ile Lys Lys Asn Glu Ile Gly Asn Phe Lys 
945                 950                 955                 960 


Ile Asn Phe Asp Val Leu Ser Asn Leu Glu Cys Asn Ser Glu Val Glu 
                965                 970                 975     


Val Lys Lys Val Ile Gly Gln Asn Ser Lys Lys Leu Glu Ser Phe Ile 
            980                 985                 990         


Gln Asn Thr Ile Asp Glu Tyr Lys  Ser Asn Ile Arg Thr  Leu Phe Ser 
        995                 1000                 1005             


Ser Glu  Phe Leu Glu Lys Tyr  Lys Glu Glu Ile Asp  Asn Leu Val 
    1010                 1015                 1020             


Glu Asp  Thr Glu Ser Glu Asn  Glu Asn Lys Phe Glu  Lys Ile Tyr 
    1025                 1030                 1035             


Tyr Pro  Lys Glu His Lys Asn  Glu Leu Tyr Ile Tyr  Lys Lys Asn 
    1040                 1045                 1050             


Leu Phe  Phe Asn Ile Gly Asn  Pro Asn Phe Asp Lys  Ile Tyr Gly 
    1055                 1060                 1065             


Ile Ile  Ser Lys Asp Ile Lys  Asn Ala Asn Thr Glu  Ile Leu Phe 
    1070                 1075                 1080             


Asp Asp  Asp Ile Arg Lys Asn  Lys Ile Ser Lys Ile  Asp Val Ile 
    1085                 1090                 1095             


Leu Lys  Asn Leu Asn Asn Lys  Leu Asn Gly Tyr Ser  Asn Asp Tyr 
    1100                 1105                 1110             


Lys Glu  Lys Tyr Val Asn Lys  Leu Lys Glu Asn Asn  Asp Phe Phe 
    1115                 1120                 1125             


Thr Lys  Asn Ile Gln Asn Glu  Asn Tyr Asn Ser Phe  Glu Glu Phe 
    1130                 1135                 1140             


Lys Glu  Asp Tyr Asn Lys Val  Ser Glu Tyr Lys Lys  Ile Arg Asp 
    1145                 1150                 1155             


Leu Val  Glu Phe Asn Tyr Leu  Asn Lys Ile Glu Ser  Tyr Leu Ile 
    1160                 1165                 1170             


Asp Ile  Asn Trp Lys Leu Ala  Ile Gln Met Ala Arg  Phe Glu Arg 
    1175                 1180                 1185             


Asp Met  His Tyr Ile Val Asn  Gly Leu Arg Glu Leu  Gly Ile Ile 
    1190                 1195                 1200             


Lys Leu  Asn Gly Tyr Asn Thr  Gly Ile Ser Arg Ala  Tyr Pro Lys 
    1205                 1210                 1215             


Arg Asp  Gly Ser Asp Asp Phe  Tyr Thr Thr Thr Ala  Tyr Tyr Lys 
    1220                 1225                 1230             


Phe Phe  Asp Glu Glu Ser Tyr  Lys Lys Phe Glu Lys  Ile Cys Tyr 
    1235                 1240                 1245             


Lys Phe  Gly Ile Asp Leu Ser  Glu Asn Ser Glu Ile  Asn Lys Pro 
    1250                 1255                 1260             


Glu Asn  Glu Ser Ile Arg Asn  Tyr Ile Ser His Phe  Tyr Ile Val 
    1265                 1270                 1275             


Arg Asn  Pro Phe Ala Asp Tyr  Ser Ile Val Glu Gln  Ile Asp Arg 
    1280                 1285                 1290             


Val Ser  Asn Leu Leu Ser Tyr  Ser Thr Arg Tyr Asn  Asn Ser Thr 
    1295                 1300                 1305             


Tyr Ala  Ser Val Phe Glu Val  Phe Lys Lys Asp Val  Asp Leu Asp 
    1310                 1315                 1320             


Tyr Asp  Glu Leu Lys Lys Lys  Phe Lys Leu Ile Gly  Asn Asn Asp 
    1325                 1330                 1335             


Ile Leu  Glu Arg Leu Met Lys  Pro Lys Lys Val Ser  Val Leu Glu 
    1340                 1345                 1350             


Leu Glu  Ser Tyr Asn Ser Asn  Tyr Val Lys Asn Leu  Ile Ile Lys 
    1355                 1360                 1365             


Leu Leu  Thr Lys Arg Lys Asn  Thr Asn Asp Thr Leu  
    1370                 1375                 1380 


<210>  536
<211>  1194
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  536

Met Lys Val Thr Lys Ile Asp Gly Leu Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ile Glu Asp Ala Ser Gln Lys Asn Glu Thr 
            20                  25                  30          


Leu Glu Arg Leu Glu Asn Leu Lys Gly Ile Lys Leu Gly Asn Tyr Ile 
        35                  40                  45              


Lys Asn Thr Asp Lys Thr Lys Asn Lys Asp Asn Lys Lys Arg Arg Lys 
    50                  55                  60                  


Gly Leu Lys Glu Tyr Phe Ser Glu Ile Thr Leu Arg Lys Glu Asn Glu 
65                  70                  75                  80  


Lys Tyr Val Leu Leu Lys Gly Lys Lys Leu Lys Lys Ile Asn Asn Asp 
                85                  90                  95      


Ile Lys Asp Thr Asp Ile Lys Ala Lys Asp Lys Lys Glu Glu Val Phe 
            100                 105                 110         


Asp Ile Leu Lys Glu Ile Leu Lys Leu Asn Leu Leu Ala Asn Asp Ala 
        115                 120                 125             


Glu Glu Lys Ile Gln Phe Asp Ser Ile Lys Leu Lys Asn Val Phe Gly 
    130                 135                 140                 


Lys Asp Phe Val Lys Lys Glu Leu Gln Ile Lys Ser Ile Glu Glu Ser 
145                 150                 155                 160 


Leu Glu Lys Asn Lys Ala Asp Tyr Arg Lys Glu Phe Ile Glu Thr Glu 
                165                 170                 175     


Asn His Lys Tyr Gly Asn Val Lys Gly Lys Asn Lys Arg Ser His Ile 
            180                 185                 190         


Tyr Glu Tyr Tyr Lys Lys Ser Glu Asn His Lys Lys Phe Glu Asp Asn 
        195                 200                 205             


Ile Arg Glu Ala Phe Glu Lys Leu Tyr Thr Glu Glu Asn Ile Lys Glu 
    210                 215                 220                 


Leu Tyr Ser Lys Ile Glu Gln Val Leu Lys Lys Thr His Leu Lys Ser 
225                 230                 235                 240 


Ile Val Trp Glu Phe Tyr Lys Asn Glu Ile Ile Gly Glu Ser Glu Phe 
                245                 250                 255     


Ser Lys Lys Asn Gly Asp Gly Ile Ser Ile Leu Tyr Asn Gln Ile Lys 
            260                 265                 270         


Asp Ser Ile Lys Lys Glu Glu Asn Phe Ile Glu Phe Ile Glu Asn Ile 
        275                 280                 285             


Gly Asn Leu Glu Leu Lys Asp Leu Thr Lys Ser Gln Ile Phe Tyr Lys 
    290                 295                 300                 


Tyr Phe Leu Glu Asn Glu Glu Leu Asn Asp Glu Asn Ile Lys Phe Val 
305                 310                 315                 320 


Phe Cys Tyr Phe Val Glu Ile Glu Val Ser Asp Leu Leu Lys Gly Asn 
                325                 330                 335     


Val Tyr Lys Ala Ser Lys Ile Tyr Glu Asn Lys Ile Lys Asn Ile Phe 
            340                 345                 350         


Glu Tyr Gly Lys Leu Lys Lys Leu Ile Val Tyr Lys Leu Glu Asn Lys 
        355                 360                 365             


Leu Asn Asn Tyr Val Arg Asn Cys Gly Lys Tyr Asn Tyr His Met Glu 
    370                 375                 380                 


Asn Gly Asp Ile Ala Thr Ser Asp Ile Asn Met Arg Asn Arg Gln Thr 
385                 390                 395                 400 


Glu Ala Phe Leu Arg Ser Met Ile Gly Val Ser Ser Phe Gly Tyr Phe 
                405                 410                 415     


Ser Leu Arg Asn Ile Leu Gly Val Asn Asp Asp Asp Phe Tyr Glu Ile 
            420                 425                 430         


Glu Glu Asp Leu Thr Glu Glu Glu Arg Lys Asn Glu Ser Asn Ala Leu 
        435                 440                 445             


Lys Lys Ala Lys Glu Asp Ile Thr Ser Lys Ser Ile Phe Glu Lys Val 
    450                 455                 460                 


Val Asp Lys Ser Phe Glu Lys Lys Gly Ile Tyr Ser Ile Lys Glu Asn 
465                 470                 475                 480 


Leu Lys Met Phe Tyr Gly Asp Ser Phe Asp Lys Ala Asn Glu Asp Glu 
                485                 490                 495     


Leu Lys Gln Phe Phe Val Asn Met Leu Asn Ala Ile Thr Ser Ile Arg 
            500                 505                 510         


His Arg Val Val His Tyr Asn Met Asn Thr Asn Ser Glu Asn Ile Phe 
        515                 520                 525             


Asn Phe Ser Asp Ile Glu Val Ser Arg Leu Leu Lys Asn Ile Phe Glu 
    530                 535                 540                 


Lys Glu Thr Asp Lys Arg Glu Leu Lys Leu Lys Ile Phe Arg Gln Leu 
545                 550                 555                 560 


Asn Ser Ala Gly Val Phe Asp Tyr Trp Glu Ser Trp Lys Ile Lys Lys 
                565                 570                 575     


Tyr Leu Glu Asn Ile Glu Phe Lys Phe Val Asn Lys Asn Ile Pro Phe 
            580                 585                 590         


Val Pro Ser Phe Thr Lys Leu Tyr Asn Arg Ile Asp Asn Leu Lys Gly 
        595                 600                 605             


Asn Asn Ala Leu Lys Leu Gly Asn Tyr Ile Thr Ile Pro Lys Arg Lys 
    610                 615                 620                 


Glu Ala Arg Asp Ser Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly 
625                 630                 635                 640 


Glu Phe Val Glu Lys Phe Val Asn Asn Asn Asp Asn Phe Glu Lys Ile 
                645                 650                 655     


Phe Arg Glu Ile Ile Glu Ile Asn Lys Asn Ala Gly Thr Asn Thr Lys 
            660                 665                 670         


Thr Lys Phe Tyr Lys Leu Glu Lys Phe Glu Thr Leu Lys Ala Asn Thr 
        675                 680                 685             


Pro Thr Glu Tyr Leu Glu Lys Leu Gln Ser Leu His Gln Ile Asn Tyr 
    690                 695                 700                 


Asp Arg Glu Lys Ile Glu Glu Ala Lys Asp Ile Tyr Val Asp Phe Val 
705                 710                 715                 720 


Gln Lys Ile Phe Leu Lys Gly Phe Ile Asn Tyr Leu Gln Lys Ser Asn 
                725                 730                 735     


Ser Leu Lys Pro Leu Asn Leu Leu Asn Leu Lys Lys Asp Glu Val Ile 
            740                 745                 750         


Asn Ser Glu Lys Ser Ser Tyr Asp Glu Lys Leu Lys Gln Trp Glu Asn 
        755                 760                 765             


Asn Gly Ser Lys Leu Ser Glu Met Pro Lys Glu Ile Tyr Lys Tyr Ile 
    770                 775                 780                 


Lys Glu Ile Asn Ile Asn Lys Ile Asn Tyr Ser Asn Arg Met Ser Ile 
785                 790                 795                 800 


Phe Tyr Leu Leu Leu Lys Leu Ile Asp His Arg Glu Leu Thr Asn Leu 
                805                 810                 815     


Arg Gly Asn Leu Glu Lys Tyr Glu Ser Met Asn Lys Asn Lys Ile Tyr 
            820                 825                 830         


Ser Glu Glu Leu Asn Ile Val Asn Leu Val Ser Leu Asp Asn Asn Lys 
        835                 840                 845             


Val Arg Thr Asn Phe Ser Val Glu Ala Glu Asp Ile Gly Lys Phe Leu 
    850                 855                 860                 


Lys Thr Glu Thr Ser Ile Lys Asn Asn Lys Gln Leu Asn Asn Phe Ser 
865                 870                 875                 880 


Glu Ile Phe Ala Asp Gly Glu Asn Val Ile Lys His Arg Ser Phe Tyr 
                885                 890                 895     


Asn Ile Lys Lys Tyr Gly Ile Leu Asp Leu Leu Glu Lys Ile Val Thr 
            900                 905                 910         


Lys Ala Asp Leu Lys Ile Thr Lys Glu Glu Ile Lys Lys Tyr Lys Asn 
        915                 920                 925             


Leu Gln Lys Glu Leu Glu Lys Asn Asp Phe Tyr Lys Ile Gln Glu Asn 
    930                 935                 940                 


Ile His Arg Lys Tyr Asn Gln Lys Pro Asn Leu Ile Ser Arg Thr Glu 
945                 950                 955                 960 


Asn Lys Lys Asp Phe Asn Asp Tyr Lys Lys Ala Ile Glu Asn Ile Gln 
                965                 970                 975     


Asn Tyr Thr Gln Leu Lys Asn Lys Ile Glu Phe Asn Asp Leu Asn Leu 
            980                 985                 990         


Leu Gln Ser Leu Leu Phe Arg Ile  Leu His Arg Leu Ala  Gly Tyr Thr 
        995                 1000                 1005             


Ser Leu  Trp Glu Arg Asp Leu  Gln Phe Lys Leu Lys  Gly Glu Phe 
    1010                 1015                 1020             


Pro Glu  Asp Lys Tyr Ile Asp  Glu Ile Phe Asn Ser  Asp Arg Asn 
    1025                 1030                 1035             


Asn Asn  Gln Lys Tyr Lys Ser  Gly Gly Ile Ala Tyr  Lys Tyr Val 
    1040                 1045                 1050             


Asp Phe  Leu Ile Glu Lys Glu  Glu Gly Lys Arg Ala  Gly Lys Asn 
    1055                 1060                 1065             


Lys Val  Lys Lys Arg Ser Glu  Lys Glu Gly Ser Phe  Ile Ile Arg 
    1070                 1075                 1080             


Asn Tyr  Ile Ala His Phe Asn  Tyr Ile Pro Asp Ala  Glu Lys Ser 
    1085                 1090                 1095             


Ile Leu  Glu Ile Leu Glu Glu  Leu Arg Glu Leu Leu  Lys Tyr Asp 
    1100                 1105                 1110             


Arg Lys  Leu Lys Asn Ala Val  Met Lys Ser Val Lys  Asp Ile Phe 
    1115                 1120                 1125             


Lys Glu  Tyr Gly Phe Ile Val  Glu Phe Gly Ile Ser  His Glu Ser 
    1130                 1135                 1140             


Asn Asn  Lys Lys Ile Thr Ile  Asn Lys Val Tyr Ser  Glu Lys Ile 
    1145                 1150                 1155             


Glu His  Leu Lys Lys Ala Lys  Leu Glu Lys Glu Asp  Lys Leu Glu 
    1160                 1165                 1170             


Thr Thr  Arg Asn Ser Glu Asp  Leu Cys Lys Leu Val  Lys Val Met 
    1175                 1180                 1185             


Leu Glu  Tyr Lys Lys Ser 
    1190                 


<210>  537
<211>  1354
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  537

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Thr Glu Asn Lys Asn Glu Glu Gln Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Cys Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Ile Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Gln Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Pro Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Glu Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Glu Leu Thr 
    610                 615                 620                 


Glu Tyr Phe Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Thr Asn Asn Val Trp Lys Tyr Tyr Asp Ile Glu Val 
                645                 650                 655     


Ile Asn Asn Ile Met Gly Lys Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Asn Asn Ile Ile Ser Arg Pro Ala Leu Pro 
        675                 680                 685             


Gln Leu Met Asp Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Lys Lys Tyr Trp Ser Ser Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Glu 
                725                 730                 735     


Lys Pro Glu Asp Asn Ile Lys Glu Arg Phe Phe Arg Ala Met Glu Lys 
            740                 745                 750         


Glu Ser Gly Gln Ala Lys Asp Gly Lys Glu Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Glu Asn Arg Ile Asp Gln Ile Gly Arg Glu Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Val Glu Tyr Met Leu Gln Asn Arg Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Gly Asp Gly Lys Thr Asn Lys Lys Gln 
                805                 810                 815     


Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Ile Cys Ile Arg Ser Ala 
            820                 825                 830         


Phe Thr Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro Val 
        835                 840                 845             


Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Thr Asp Gly 
    850                 855                 860                 


Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Glu Thr Phe Asn Asp 
865                 870                 875                 880 


Ala Glu Ser Gly Ser Phe Trp Tyr Met Ala Ala His Phe Ile Asn Gln 
                885                 890                 895     


Lys Tyr Leu Asn His Leu Ile Gly Ser Ile Arg Asn Tyr Leu Gln Phe 
            900                 905                 910         


Thr Glu Asp Ile Glu Asp Arg Ala Leu Ser Leu Gly Asp Cys Ala Asp 
        915                 920                 925             


Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu Ile 
    930                 935                 940                 


Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met Glu 
945                 950                 955                 960 


Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Ala Tyr Leu Ser Gly Phe 
                965                 970                 975     


Val Asp Tyr Asn Val Ser Lys Lys Glu Thr Asp Ile Glu Lys Ala Leu 
            980                 985                 990         


Tyr Gly Phe Cys Arg Gln Lys Phe  Lys Val Asp Gly Lys  Glu Tyr Met 
        995                 1000                 1005             


Ala Gly  Ile Tyr Tyr Asp Gly  Glu Asn Leu Ile Pro  Asn Arg Asn 
    1010                 1015                 1020             


Ile Ile  Arg Ala Asn Met Tyr  Gly Asn Val Ser Cys  Leu Lys Pro 
    1025                 1030                 1035             


Tyr Met  Asp Arg Ile Thr Leu  Lys Glu Ile Arg Thr  Met Tyr Ala 
    1040                 1045                 1050             


Asp Gln  Asn Lys Leu Asp Thr  Val Leu Lys Glu Gly  Val Cys Arg 
    1055                 1060                 1065             


Thr Glu  Glu Glu Gln Lys Ala  Tyr Arg Glu Tyr Gln  Asn Glu Lys 
    1070                 1075                 1080             


Asn Arg  Ile Glu Leu Phe Asp  Leu Cys Thr Tyr Thr  Gln Ile Leu 
    1085                 1090                 1095             


Asn Asp  Met Gln Ala Lys Leu  Ile Arg Trp Ser Tyr  Met Arg Glu 
    1100                 1105                 1110             


Arg Asp  Leu Met Tyr Tyr Gln  Leu Gly Tyr Tyr Tyr  Thr Lys Leu 
    1115                 1120                 1125             


Phe Trp  Thr Asp Ser Ile Ser  Glu Glu Asp Ala Arg  Arg Arg Leu 
    1130                 1135                 1140             


Met Gly  Glu Leu Val Asn Val  Glu Asp Gly Val Ile  Leu Tyr Gln 
    1145                 1150                 1155             


Ile Leu  Ala Phe Asn Ser Tyr  Asn Leu Pro Ile Ile  Ala Asn Lys 
    1160                 1165                 1170             


Asn Asn  Thr Val Thr Phe Leu  Lys Gly Glu Gly Ser  Ile Gly Gly 
    1175                 1180                 1185             


Lys Ala  Ile Thr Ala Phe Leu  Lys Asn Tyr Glu Asn  Ala Glu Arg 
    1190                 1195                 1200             


Ile Tyr  Glu Glu Ala Leu Asp  Leu Phe Glu Asn Thr  Asp Glu His 
    1205                 1210                 1215             


Ala Ala  Ile Ile Asn Thr Arg  Asn Tyr Ile Glu His  Phe Lys Tyr 
    1220                 1225                 1230             


Phe Ile  Lys Ser Asp Arg Ser  Met Met Asp Leu Tyr  Ser Glu Val 
    1235                 1240                 1245             


Tyr Asp  Arg Phe Phe Arg His  Asp His Asn Arg Lys  Lys Asn Val 
    1250                 1255                 1260             


Pro Asp  Ser Leu Lys Asn Val  Leu Ala Asp Asn Phe  Met Ile Ala 
    1265                 1270                 1275             


Asp Ile  Ser Met Glu Leu Gly  Ser Lys Lys Val Gly  Glu Lys Lys 
    1280                 1285                 1290             


Lys Gly  Phe Arg Glu His Lys  Ala Ala Arg Ile Glu  Phe Thr Asp 
    1295                 1300                 1305             


Arg Gly  Ile Arg Ser Thr Asp  Met Thr Tyr Thr Val  Lys Pro Asp 
    1310                 1315                 1320             


Pro Lys  Asp Ser Lys Lys Asp  Glu Lys Val Leu Val  Pro Ala Arg 
    1325                 1330                 1335             


Ser Glu  Val Phe Leu Lys Gln  Phe Gln Lys Ile Leu  Glu Tyr Arg 
    1340                 1345                 1350             


Ile 
    


<210>  538
<211>  1383
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  538

Met Lys Ile Leu Gln Ser Glu Gly Val Ser Tyr Thr Glu Gln Lys Glu 
1               5                   10                  15      


Glu Gly Gly Leu Gly Arg Gly Val Arg Asn Pro Lys Gln Pro Tyr Asn 
            20                  25                  30          


Thr Pro Asn Asn Leu Ile Arg Asp Gly Arg Val Asn Tyr Glu Val Leu 
        35                  40                  45              


Glu Glu Tyr Ile Gly Ala Glu Pro Ala Leu Ala Leu Arg Gln Thr Ile 
    50                  55                  60                  


Ala Val Leu Asp Lys Thr Ile Arg Lys Pro His Thr Leu Arg Gly Phe 
65                  70                  75                  80  


His Ser Gly Ala Tyr Val His Arg Val Arg Leu Ala Gly Ala Leu Arg 
                85                  90                  95      


Val Arg Leu Phe Glu Lys Phe Lys Glu Glu Ile Arg Ser Asn Phe Gly 
            100                 105                 110         


Pro Ser Gly Leu Thr Lys Tyr Arg Asp Ala Trp Asn Trp Lys Ala His 
        115                 120                 125             


Pro Tyr Gly Ile Arg Asp Val Ser Val Val Asn Pro Lys Gly Asp Lys 
    130                 135                 140                 


Asn Tyr Glu Arg Leu Glu Asn Tyr Glu Thr Lys Ala Thr Ala Asp Lys 
145                 150                 155                 160 


Gly Ser Lys Lys Gln Asn Arg Thr Ala Ser Asp Phe Glu Gly Arg Trp 
                165                 170                 175     


Leu Lys Ala Phe Ser Gly Asp Thr Pro Ile Ser Leu Asp Asp Gln Asp 
            180                 185                 190         


Ile Asp Trp Lys Lys Val Ala Asp Arg Ile Tyr Asp His Leu Trp Thr 
        195                 200                 205             


Gln Glu Ile Leu Ile Asn Gly Glu Pro Arg Glu Lys Arg Asp Arg Glu 
    210                 215                 220                 


Thr Glu Thr Gly Arg Tyr Pro Ser Thr Gly Lys Gly Leu Ile Ala Ser 
225                 230                 235                 240 


Arg Gly Gly Ala Ile Lys Asn Ala Ala Ser Asp Pro Arg Ile Ala Arg 
                245                 250                 255     


Arg Asp Glu Lys Lys Ala Asn Trp Ser Asp Ile Thr Ala Ala Phe Tyr 
            260                 265                 270         


Phe Asn Glu Asp Cys Arg Leu Val Val Asp Ile Tyr Asp Glu Thr Leu 
        275                 280                 285             


Asp Leu Leu Asn Lys Gly Gly Arg Val Lys Arg Asn Leu His Gly Ser 
    290                 295                 300                 


Phe Ile Tyr Asp His Phe Gly Ser Leu Glu Lys Arg Ala Gly Ala Glu 
305                 310                 315                 320 


Lys Ile Asp Arg Lys Glu Leu Trp Asn Leu His Asn His Val Arg Arg 
                325                 330                 335     


Tyr Tyr Gln Gln Leu Phe Lys Ser Asp Arg Leu Lys Gln Ala Ala Phe 
            340                 345                 350         


Glu Gly Asp Val Glu His Met Arg Lys Ile Leu Pro His Glu Asn Ala 
        355                 360                 365             


Gln Leu Leu Arg Ile Leu Ile Gly Lys Asp Glu Asn Thr Asp Met Ser 
    370                 375                 380                 


Gln Ile Ile Arg Leu Gly Lys Leu Ile Val His Ala Ala Asp Leu Pro 
385                 390                 395                 400 


Thr Glu Ala Ala Lys Gly Asp Leu Asn Ala Ala Phe Gln Glu Arg Leu 
                405                 410                 415     


Asn Arg Phe Ala Thr Ser Asp Gly Gln Ser Glu Ile Lys Arg Asn Glu 
            420                 425                 430         


Ala Phe Thr Arg Ile Trp Arg His Ala Ile Asn Leu Ser His Asn Ser 
        435                 440                 445             


Leu Ser Thr Trp Leu Asp Pro Lys Asn Lys Leu Gly Lys Lys Asn Asp 
    450                 455                 460                 


Ile Phe Asp Lys Ser Leu Ser Ile Phe Val Val Asn Asn Leu His Pro 
465                 470                 475                 480 


Gln Ala Phe Arg Ala His Ala Glu Ile Leu Phe Gly Asn Asp Lys Ile 
                485                 490                 495     


Gly Gln Leu Gly Asp Asp Asn Asn Asn Leu Val Ser Arg Ala Ser Leu 
            500                 505                 510         


Phe Cys Pro Asp Asp Asp Asp Ala Ala Lys Glu Ile Ala Trp Gly Met 
        515                 520                 525             


Leu Arg Leu Ala Ala Gln Leu Arg His Asn Val Asn His Phe Ala Thr 
    530                 535                 540                 


Lys Asn Arg Leu Leu Ala Ala Leu Lys Asn Gln Val Val Lys Val Pro 
545                 550                 555                 560 


Lys Glu Leu Asn Asn Thr Asp Asn Arg Gly Ala Asn Glu Ile Ser Arg 
                565                 570                 575     


Ile Ala Met Ser Ala Ile Glu Asn Leu Leu Ala Phe Asp Arg Ser Val 
            580                 585                 590         


Gln Lys Lys Ala Leu Ala Asp Lys Leu Asn Gln Val Lys Ala Ser Ala 
        595                 600                 605             


Tyr Leu Glu Pro His Gln Val Ser Gln Leu Ile Val Gln Ala Ser Ser 
    610                 615                 620                 


Leu Gly Asp Ala Ser Phe Pro Ile Pro Arg Leu Thr Asn Val Leu Lys 
625                 630                 635                 640 


Gln Leu Ser Asn Ile Val Asp Phe Ala Pro Glu Gly Ser Pro Glu Leu 
                645                 650                 655     


Leu Lys Pro Leu Gly Asp Leu Gly Gly Met Phe Gly Thr Glu Gly Thr 
            660                 665                 670         


Lys Asn Pro Val Phe Leu Leu Lys Thr Asn Leu Leu Arg Leu Val Tyr 
        675                 680                 685             


Gly Ser Gly Phe Ser Asn Trp Leu Ala Thr Ile Asp Asp Asp Met Thr 
    690                 695                 700                 


Gln Ser Val Leu Arg Asp Ile Val Lys Ala Gln Thr Phe Arg Lys Glu 
705                 710                 715                 720 


Thr Met Asn Lys Glu Arg Gln Arg Phe Tyr Ala Val Val Glu Asn Ile 
                725                 730                 735     


Thr Asp Glu Leu Gln Ile Ser Gly Glu Ala Asp Leu Thr Asp Ile Leu 
            740                 745                 750         


Gln Thr Ile Thr Ala Arg Met Ala Arg Val Glu Arg Leu Asn Glu Gly 
        755                 760                 765             


Tyr Asn Pro Lys Arg Thr Lys Gln Arg Ala Val Ser Asn Arg Ile Glu 
    770                 775                 780                 


Lys Phe Arg Leu Glu Leu Phe Gly Asn Leu Phe Ala Lys Tyr Leu Gln 
785                 790                 795                 800 


Asp Glu Glu Leu Asn Trp Leu Ala Arg Phe Asp Met Gln Ala Lys Pro 
                805                 810                 815     


Leu Glu Leu Phe Glu Glu Ile Lys Pro Glu His Val Lys Thr Thr Gly 
            820                 825                 830         


Ala Asp Ile Ala Pro Trp His Ser Gln Phe Tyr Ala Phe Leu Tyr Leu 
        835                 840                 845             


Ile Pro Val Glu Ala Ala Ala Arg Leu Arg Asn Gln Phe Arg Lys Thr 
    850                 855                 860                 


Ala Ile Leu Glu Ala Lys Gly Asp Thr Ser Ile Gly Asn Glu Leu Ala 
865                 870                 875                 880 


Ser Asn Asp Val Glu Ala Leu His Glu Leu Val Ser Leu Tyr Leu Leu 
                885                 890                 895     


Val His Asp Thr Gly Phe Ser Gly Thr Glu Pro Ile Val Ser Glu Glu 
            900                 905                 910         


Phe Asn Glu Thr Leu Tyr Gln Asn Glu Asp Lys Phe Glu Thr Val Tyr 
        915                 920                 925             


Ser Val Glu Asn Glu Asp His Asp Leu Ser Leu Ser Gly Thr Arg Arg 
    930                 935                 940                 


Gly Leu Arg Gln Ile Met Arg Phe Gly His Glu Gly Val Leu Thr Lys 
945                 950                 955                 960 


Ile Phe Glu Lys His Lys Ile Thr Asp Asn Glu Val Thr Ala Phe Cys 
                965                 970                 975     


Ala Leu Arg Asp Ala Asp Gly Glu Gln Ala Ala Ile Lys Leu Ile Ala 
            980                 985                 990         


Asn Arg Thr Arg Ala Arg Glu Ala  Val Phe Arg Arg Tyr  Glu Asp Leu 
        995                 1000                 1005             


Gln Asn  Arg Asp Leu Lys Pro  Asp Gln Lys Pro Lys  Ile Glu Arg 
    1010                 1015                 1020             


Asp Ile  Ile Gln Lys Ala Ser  Ala Tyr Lys Ser Ala  Ala Glu Ile 
    1025                 1030                 1035             


Met Met  Ala His Glu Phe Lys  Val Arg Ser Gly Arg  Leu His Asp 
    1040                 1045                 1050             


His Ala  Arg Leu Tyr Gly Leu  Leu Met Lys Val Val  Gly Arg Leu 
    1055                 1060                 1065             


Leu Asp  Tyr Thr Leu Leu Trp  Glu Arg Asp Val Tyr  Tyr Ala Tyr 
    1070                 1075                 1080             


Leu Gly  Leu Leu Ala Arg Gln  Ile Gly Val Asn Asn  Leu Lys Leu 
    1085                 1090                 1095             


Val Lys  Ser Asp Leu Lys Glu  Ser Gln Tyr Lys His  Asn Asn Asp 
    1100                 1105                 1110             


Ala Val  Arg Asp Val Pro Ile  Arg Tyr Gly Leu Gln  Leu Pro Glu 
    1115                 1120                 1125             


Asn Val  Ala Ser Leu Leu Ser  Lys Lys Tyr Phe Asn  Tyr Leu Gly 
    1130                 1135                 1140             


Asp Leu  Thr Asp Ala Asn Leu  Thr Lys Ala Arg Gln  Ser Asp Phe 
    1145                 1150                 1155             


Ile Phe  Lys Ala Asp Val Lys  Ser Gly Phe Leu Ser  Leu Trp Asn 
    1160                 1165                 1170             


Met Glu  Thr Gly Phe Asp Phe  Pro Leu Asn Lys Ser  Val Glu Asp 
    1175                 1180                 1185             


Leu Leu  Asp Ala Asn Thr Lys  Pro Ile Phe Asp Arg  Tyr Phe Ser 
    1190                 1195                 1200             


Asn Ser  Gly Pro Met Asn Pro  Lys Asp Lys Ala Ala  Asn Ala Ala 
    1205                 1210                 1215             


His Lys  Ala Lys Gly Gln Leu  Pro His Lys Ser Tyr  Lys Arg Leu 
    1220                 1225                 1230             


Lys Lys  Arg Asp Ile Arg Asn  Asp Phe Ala His Tyr  Asn Val Leu 
    1235                 1240                 1245             


Arg Gly  Lys Asn Arg Ala Thr  Leu Asn Leu Ser Tyr  Leu Val Asn 
    1250                 1255                 1260             


Pro Val  Arg Ser Leu Leu Gly  Tyr Asp Arg Lys Leu  Lys Asn Ala 
    1265                 1270                 1275             


Val Ala  Lys Ser Ile Arg Lys  Ile Leu Glu Glu Glu  Gly Val Thr 
    1280                 1285                 1290             


Ile Lys  Trp Gln Leu Val Glu  Asp Arg Leu Lys Asn  Ala Glu Ile 
    1295                 1300                 1305             


Ile Pro  Ile Val Glu Thr His  Leu Ala Asp Leu Arg  Lys Met Asp 
    1310                 1315                 1320             


Gly Lys  Trp Val Asp Phe Val  Leu Pro Lys Ser Ser  Pro Arg Phe 
    1325                 1330                 1335             


Thr Ser  Met Val Gln Ala Leu  Phe Glu Phe Gly Arg  Ser Gly Tyr 
    1340                 1345                 1350             


Asn Ser  Gly Gly Gly Gln Pro  Ser Tyr Pro Asp Asn  Phe Leu Glu 
    1355                 1360                 1365             


Ala Leu  His Ile Asp Gly Tyr  Asp Ile Thr Val Val  Ala Glu Val 
    1370                 1375                 1380             


<210>  539
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  539

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Lys Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn Gln Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Ile Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Asn Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Val Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Phe Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Gln Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Lys Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ala Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asp Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Ile Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Met Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Glu  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Ala Gln Gly  Gly Ala Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Arg Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Lys Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Met Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Cys Ile  Ser Ser Ile Lys Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Thr Leu Ile Thr Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Ser Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Gly Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  540
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  540

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Gly Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asp 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  541
<211>  1363
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  541

Met Lys Ile Ile Arg Pro Lys Gly Lys Ser Phe Thr Thr Leu Thr Gln 
1               5                   10                  15      


Thr Asp Ala Leu Glu Arg Gly Ile Arg Arg Ala Gly Asp Lys Val Ala 
            20                  25                  30          


His Pro Val Ala Phe Ser Ala Ser Arg Asp Val Ser Ala Asn Gln Leu 
        35                  40                  45              


Pro Glu Tyr Leu Ser Ala Asp Gln Glu Leu Val Leu Arg Gln Leu Val 
    50                  55                  60                  


Ser Gly Leu Asp Lys Val Val Arg Lys Pro Arg Arg Asn Asn Leu Arg 
65                  70                  75                  80  


Asn Phe Gln Ala Asp Ala Tyr Val Asp Arg Thr Lys Leu Gly Leu Glu 
                85                  90                  95      


Leu Trp Asn Val Phe Glu Glu Gln Cys Gly Asp Ser Leu Arg Ser Leu 
            100                 105                 110         


Asp Gly Gly Ala Asp Val Leu Ala Asn Leu Ala Arg Ile Trp Arg Trp 
        115                 120                 125             


Lys Val His Pro Tyr Ser Glu Phe Ile Val Asp Met Leu Ser Pro Arg 
    130                 135                 140                 


Ser Asp Lys Asn Ala Glu Val Ile Ala Lys Tyr Gly Asp Lys Glu Leu 
145                 150                 155                 160 


Ser Arg Ser Asp Phe Tyr Gly Arg Trp His Glu Ala Phe Trp Lys Thr 
                165                 170                 175     


Thr Ser Asn Gly Arg Ala Asp Tyr Ser Ala Thr Ala Glu Ala Ile Trp 
            180                 185                 190         


Ala His Leu Phe Gln Glu Glu Ile Lys Ile Thr Lys Glu Gln Arg Asn 
        195                 200                 205             


Arg Lys Asn Thr Thr Asp Trp Pro Ala Lys Gly Leu Ala Gln Ala Lys 
    210                 215                 220                 


Gly Arg Ser Ile Ala Leu Ser Ala His Asp Pro Ala Lys Gly Gly Thr 
225                 230                 235                 240 


Leu Arg Leu Asp Asp Thr Val Asp Glu Ala Val Ile Ala Leu Tyr Phe 
                245                 250                 255     


Ala His Asp Val Val Lys Glu Leu Arg Asp Ala Val Leu Thr Ala Ala 
            260                 265                 270         


Lys Ala Ser Ser Gly Arg Asn Ala Gln Phe Ser Gln Ser Asp Phe Gly 
        275                 280                 285             


Arg Val Leu Tyr Glu His Phe Gly Pro Ile Ile Lys Arg Pro Leu Asp 
    290                 295                 300                 


Glu Ala Leu Asn Arg Ser Leu Trp Arg Leu His Asn Ala Val Arg Gly 
305                 310                 315                 320 


Phe Tyr Gln Glu Leu Ala Arg Ser Glu Gly Tyr Ser Arg Ala Met Arg 
                325                 330                 335     


Asp Pro Val Arg Glu Leu Gly Lys Leu Glu Glu Leu Leu Pro Arg Asp 
            340                 345                 350         


His Gln His Leu Ile Gln Ile Leu Gly Ala Lys Asp Arg Asn Ala Gln 
        355                 360                 365             


Ile Ser Ala Leu Thr Arg Leu Gly Lys Leu Ile Ala His Ala Ser Asp 
    370                 375                 380                 


Leu Pro Ala Gly Thr Gln Asp Val Asn Ala Ala Phe Ala Glu Arg Phe 
385                 390                 395                 400 


His Phe Leu Gln Thr Ser Asp Gly Gln Asn Glu Ile Lys Arg Asn Glu 
                405                 410                 415     


Ala Phe Val Arg Val Trp Arg Thr Ser Ile Ala Leu Ser Leu Arg Thr 
            420                 425                 430         


Leu His Ala Leu Thr Ser Phe Ala His Ile Asp Gly Lys Ser Asp Asp 
        435                 440                 445             


Leu Thr Glu Thr Thr Tyr Ala Ala Gln Ala Ile Lys Arg Tyr Ala Ala 
    450                 455                 460                 


Pro Ala Thr Asp Lys Gly Lys Pro Gln Pro Cys Gln Ser Tyr Gln His 
465                 470                 475                 480 


Gly Ile Glu Leu Ile Phe Gly Ser Lys Thr Ile Pro Ser Leu Gly Gly 
                485                 490                 495     


Gly Ser Arg Ala Thr Thr Leu Leu Leu Thr Tyr Thr Gly Gly Arg Arg 
            500                 505                 510         


Asp Thr Asp Pro Asn Thr Glu Val Leu Trp Ala Phe Leu Arg Leu Ala 
        515                 520                 525             


Ser Glu Ile Arg Lys Arg Ala Tyr His Phe Asn Thr Lys Glu Arg Leu 
    530                 535                 540                 


Leu Glu Leu Ile Lys Ser Cys Pro Leu Lys Ile Thr Asp Gln Leu Val 
545                 550                 555                 560 


Ser Phe Gly Ser Arg Thr Gly Leu Ile Ala Ser Gln Ile Ala Ala Asp 
                565                 570                 575     


Ala Phe Ala Gln Leu Leu Glu Phe Asp Leu Ser Leu Gln Glu Gln Val 
            580                 585                 590         


Ile Leu Asp Glu Phe Arg Arg Leu Asp Val Ser Ala Tyr Val Lys Pro 
        595                 600                 605             


Ser Asp Leu Asp Glu Leu Tyr Ala Glu Phe Ser Arg Val Pro Asp Thr 
    610                 615                 620                 


Ile Gln His Thr Gln Pro Lys Phe Ile Ser Val Leu Arg Arg Ala His 
625                 630                 635                 640 


Ala Ile Cys Gln Gly Asp Glu Gly Lys Pro Pro Val Trp Ala Ala Pro 
                645                 650                 655     


Phe Ala Thr Leu Asp Leu Ala Gly Leu Ser Lys Val Lys Glu Gly Ala 
            660                 665                 670         


Asn His Phe Arg Leu Gly Val Leu Arg Gln Leu Tyr Lys Ser Gly Phe 
        675                 680                 685             


Ala Ala Trp Leu Ser Gln Gln Ser Asn Asn Ala Ala Leu Val Arg Ser 
    690                 695                 700                 


Ala Ile Ala Glu Val Thr Thr Phe Lys Ile Gln Arg Phe Glu Glu Tyr 
705                 710                 715                 720 


His Gly Pro Lys Ser Asp His Arg Arg Val Tyr Ala Met Ala Glu Pro 
                725                 730                 735     


Ile Ala Gln Ser Leu Ala Leu Glu Thr Ala Ala Ser Leu Glu Asp Leu 
            740                 745                 750         


Phe Arg Arg Leu Gln Ser Glu Ala Met Ser Glu Asp Ser Ile Arg Gln 
        755                 760                 765             


Thr Tyr Arg Ala Ser Ala Val Lys Gln Arg Glu Arg Met Gly Gly Val 
    770                 775                 780                 


Gly Glu Phe Arg Leu Asp Leu Phe Ala Arg Leu Phe Ala Leu Tyr Leu 
785                 790                 795                 800 


Glu Gln Thr Asn Leu Asn His Ile Trp Gly Ile Thr Gly Pro Leu Pro 
                805                 810                 815     


Pro Glu Glu Arg Ala Pro Ala Glu Arg Leu Ala Thr Phe Ala Ala Pro 
            820                 825                 830         


Ala Lys Leu Leu Asp Arg Ile Glu Pro Trp His Ser Gln Phe Tyr Val 
        835                 840                 845             


Trp Leu Tyr Leu Ile Pro Ile Asp Glu Val Ala Leu Leu Arg His Gln 
    850                 855                 860                 


Leu Arg Lys Thr Val Ala Leu Glu Ala Lys Ser Gly Ile Gly Ser Gln 
865                 870                 875                 880 


Asp Ile Leu Ser Gln Val Asp Leu Leu Met Gly Leu Tyr Leu Ser Val 
                885                 890                 895     


Tyr Asp Ala Gly Phe Asp Gly Arg Glu His Val Gly Gly Leu Asn Ala 
            900                 905                 910         


Gly Lys Leu Phe Tyr Glu Ser Pro Gln Asp Phe Glu Lys Val Tyr Ser 
        915                 920                 925             


Asp Asp Gln Ser His His Glu Ile Ser Met Pro Gly Thr Arg Arg Gly 
    930                 935                 940                 


Leu Arg Gln Ile Leu Arg Met Asp His Phe Arg Ala Leu Glu Gly Ile 
945                 950                 955                 960 


Phe Glu Lys His Gln Val Thr Thr Asp Glu Val Lys Ala Phe Gln Gln 
                965                 970                 975     


Leu Lys Leu Thr Glu Val Gln Glu Ile Leu Glu Ser Lys Ile Arg Leu 
            980                 985                 990         


Gln Lys Ser Ile Ile Ser Met Ser  Lys Gln Ala Lys Leu  Asp Thr Glu 
        995                 1000                 1005             


Ala Leu  Arg Ser Glu Cys Gln  Lys Tyr Gln Val Ser  Ala Thr Lys 
    1010                 1015                 1020             


Leu Ala  Ile Tyr Asn Phe Gln  Val Lys Ala Ala Arg  Leu Ser Glu 
    1025                 1030                 1035             


His Ala  Arg Leu His Gln Leu  Met Met Arg Val Leu  Gly Arg Leu 
    1040                 1045                 1050             


Ala Asp  Phe Ser Met Met Trp  Glu Arg Asp Arg Gln  Tyr Leu Phe 
    1055                 1060                 1065             


Leu Gly  Leu Leu Tyr Arg Arg  Ile Gly Ala Glu Asn  Phe Ile Leu 
    1070                 1075                 1080             


His Arg  Met Ala Asp Glu Ile  Gly Ile Ala Leu Pro  Ala Asp Ala 
    1085                 1090                 1095             


Gly Leu  Gly Leu Val Ala Asp  Ala Gly Ala Ala Thr  Arg Arg Ser 
    1100                 1105                 1110             


Gly Ala  Ile Ser Asp Met His  Val Gln Ala Gly Phe  Leu Pro Leu 
    1115                 1120                 1125             


Trp Asp  Pro Asp Phe Gly Phe  Val Arg Glu Gly Asp  Gly Ala Glu 
    1130                 1135                 1140             


Leu Thr  Leu Leu Ala Val Gln  Asp Arg Glu Leu Phe  Met Arg Tyr 
    1145                 1150                 1155             


Phe Gly  Lys Leu Pro Glu Glu  Asn Pro Arg Asp Val  Arg Arg Arg 
    1160                 1165                 1170             


Glu Ala  Asn Glu Ala Glu Gly  Phe Ala Arg Pro Ser  Thr Lys Asn 
    1175                 1180                 1185             


Trp Asn  Gly Ser Phe Arg Leu  Pro Lys Arg Arg Ile  Arg Asn Asp 
    1190                 1195                 1200             


Phe Ala  His Phe Asn Val Ile  Ser Gly Lys Arg Arg  Pro Asn Leu 
    1205                 1210                 1215             


Thr Tyr  Leu Met Asn Ala Ile  Arg Ser Leu Met Ser  His Asp Arg 
    1220                 1225                 1230             


Lys Met  Lys Asn Ala Val Ser  Lys Ala Val Ala Glu  Ile Val Ala 
    1235                 1240                 1245             


Glu Glu  Gly Leu Glu Ile Arg  Trp Gln Val Arg Gly  Asp Arg Leu 
    1250                 1255                 1260             


Val Asp  Pro Thr Val Ile Pro  Met Leu Glu Ser His  Leu Thr Met 
    1265                 1270                 1275             


Val Arg  Pro Lys Asp Gly Phe  Asp Pro Arg Phe His  Leu Pro Gln 
    1280                 1285                 1290             


Ala Ser  Val Arg Phe Thr Ser  Met Val Lys Ala Leu  Phe Glu Phe 
    1295                 1300                 1305             


Asp Gln  Gly Gly Tyr Arg Glu  Thr Ile Pro Trp Lys  Glu Gly Lys 
    1310                 1315                 1320             


Lys Ala  Ser Arg Gly Gln Leu  Gly Tyr Pro Lys Glu  Phe Ile Ala 
    1325                 1330                 1335             


Arg Ile  Glu Gln Asp Glu Thr  Ile His Val Pro Arg  Glu Val Leu 
    1340                 1345                 1350             


Ala Gln  Arg Tyr Lys Gly Leu  Glu Gln Lys 
    1355                 1360             


<210>  542
<211>  1363
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  542

Met Lys Ile Ile Arg Pro Lys Gly Lys Ser Phe Thr Thr Leu Thr Gln 
1               5                   10                  15      


Thr Asp Ala Leu Glu Arg Gly Ile Arg Arg Ala Gly Asp Lys Val Ala 
            20                  25                  30          


His Pro Val Ala Phe Ser Ala Ser Arg Asp Val Ser Ala Asn Gln Leu 
        35                  40                  45              


Pro Glu Tyr Leu Ser Ala Asp Gln Glu Leu Val Leu Arg Gln Leu Val 
    50                  55                  60                  


Ser Gly Leu Asp Lys Val Val Arg Lys Pro Arg Arg Asn Asn Leu Arg 
65                  70                  75                  80  


Asn Phe Gln Ala Asp Ala Tyr Val Asp Arg Thr Lys Leu Gly Leu Glu 
                85                  90                  95      


Leu Trp Asn Val Phe Glu Glu Gln Cys Gly Asp Ser Leu Arg Ser Leu 
            100                 105                 110         


Asp Gly Gly Ala Asp Val Leu Ala Asn Leu Ala Arg Ile Trp Arg Trp 
        115                 120                 125             


Lys Val His Pro Tyr Ser Glu Phe Ile Val Asp Met Leu Ser Pro Arg 
    130                 135                 140                 


Ser Asp Lys Asn Ala Glu Val Ile Ala Lys Tyr Gly Asp Lys Glu Leu 
145                 150                 155                 160 


Ser Arg Ser Asp Phe Tyr Gly Arg Trp His Glu Ala Phe Trp Lys Thr 
                165                 170                 175     


Thr Ser Asn Gly Arg Ala Asp Tyr Ser Ala Thr Ala Glu Ala Ile Trp 
            180                 185                 190         


Ala His Leu Phe Gln Glu Glu Ile Lys Ile Thr Lys Glu Gln Arg Asn 
        195                 200                 205             


Arg Lys Asn Thr Thr Asp Trp Pro Ala Lys Gly Leu Ala Gln Ala Lys 
    210                 215                 220                 


Gly Arg Ser Ile Ala Leu Ser Ala His Asp Pro Ala Lys Gly Gly Thr 
225                 230                 235                 240 


Leu Arg Leu Asp Asp Thr Val Asp Glu Ala Val Ile Ala Leu Tyr Phe 
                245                 250                 255     


Ala His Asp Val Val Lys Glu Leu Arg Asp Ala Val Leu Thr Ala Ala 
            260                 265                 270         


Lys Ala Ser Ser Gly Arg Asn Ala Gln Phe Ser Gln Ser Asp Phe Gly 
        275                 280                 285             


Arg Val Leu Tyr Glu His Phe Gly Pro Ile Ile Lys Arg Pro Leu Asp 
    290                 295                 300                 


Glu Ala Leu Asn Arg Ser Leu Trp Arg Leu His Asn Ala Val Arg Gly 
305                 310                 315                 320 


Phe Tyr Gln Glu Leu Ala Arg Ser Glu Gly Tyr Ser Arg Ala Met Arg 
                325                 330                 335     


Asp Pro Val Arg Glu Leu Gly Lys Leu Glu Glu Leu Leu Pro Arg Asp 
            340                 345                 350         


His Gln His Leu Ile Gln Ile Leu Gly Ala Lys Asp Arg Asn Ala Gln 
        355                 360                 365             


Ile Ser Ala Leu Thr Arg Leu Gly Lys Leu Ile Ala His Ala Ser Asp 
    370                 375                 380                 


Leu Pro Ala Gly Thr Gln Asp Val Asn Ala Ala Phe Ala Glu Arg Phe 
385                 390                 395                 400 


His Phe Leu Gln Thr Ser Asp Gly Gln Asn Glu Ile Lys Arg Asn Glu 
                405                 410                 415     


Ala Phe Val Arg Val Trp Arg Thr Ser Ile Ala Leu Ser Leu Arg Thr 
            420                 425                 430         


Leu His Ala Leu Thr Ser Phe Ala His Ile Asp Gly Lys Ser Asp Asp 
        435                 440                 445             


Leu Thr Glu Thr Thr Tyr Ala Ala Gln Ala Ile Lys Arg Tyr Ala Ala 
    450                 455                 460                 


Pro Ala Thr Asp Lys Gly Lys Pro Gln Pro Cys Gln Ser Tyr Gln His 
465                 470                 475                 480 


Gly Ile Glu Leu Ile Phe Gly Ser Lys Thr Ile Pro Ser Leu Gly Gly 
                485                 490                 495     


Gly Ser Arg Ala Thr Thr Leu Leu Leu Thr Tyr Thr Gly Gly Arg Arg 
            500                 505                 510         


Asp Thr Asp Pro Asn Thr Glu Val Leu Trp Ala Phe Leu Arg Leu Ala 
        515                 520                 525             


Ser Glu Ile Arg Lys Arg Ala Tyr His Phe Asn Thr Lys Glu Arg Leu 
    530                 535                 540                 


Leu Glu Leu Ile Lys Ser Cys Pro Leu Lys Ile Thr Asp Gln Leu Val 
545                 550                 555                 560 


Ser Phe Gly Ser Arg Thr Gly Leu Ile Ala Ser Gln Ile Ala Ala Asp 
                565                 570                 575     


Ala Phe Ala Gln Leu Leu Glu Phe Asp Leu Ser Leu Gln Glu Gln Val 
            580                 585                 590         


Ile Leu Asp Glu Phe Arg Arg Leu Asp Val Ser Ala Tyr Val Lys Pro 
        595                 600                 605             


Ser Asp Leu Asp Glu Leu Tyr Ala Glu Phe Ser Arg Val Pro Asp Thr 
    610                 615                 620                 


Ile Gln His Thr Gln Pro Lys Phe Ile Ser Val Leu Arg Arg Ala His 
625                 630                 635                 640 


Ala Ile Cys Gln Gly Asp Glu Gly Lys Pro Pro Val Trp Ala Ala Pro 
                645                 650                 655     


Phe Ala Thr Leu Asp Leu Ala Gly Leu Ser Lys Val Lys Glu Gly Ala 
            660                 665                 670         


Asn His Phe Arg Leu Gly Val Leu Arg Gln Leu Tyr Lys Ser Gly Phe 
        675                 680                 685             


Ala Ala Trp Leu Ser Gln Gln Ser Asn Asn Ala Ala Leu Val Arg Ser 
    690                 695                 700                 


Ala Ile Ala Glu Val Thr Thr Phe Lys Ile Gln Arg Phe Glu Glu Tyr 
705                 710                 715                 720 


His Gly Pro Lys Ser Asp His Arg Arg Val Tyr Ala Met Ala Glu Pro 
                725                 730                 735     


Ile Ala Gln Ser Leu Ala Leu Glu Thr Ala Ala Ser Leu Glu Asp Leu 
            740                 745                 750         


Phe Arg Arg Leu Gln Ser Glu Ala Met Ser Glu Asp Ser Ile Arg Gln 
        755                 760                 765             


Thr Tyr Arg Ala Ser Ala Val Lys Gln Arg Glu Arg Met Gly Gly Val 
    770                 775                 780                 


Gly Glu Phe Arg Leu Asp Leu Phe Ala Arg Leu Phe Ala Leu Tyr Leu 
785                 790                 795                 800 


Glu Gln Thr Asn Leu Asn His Ile Trp Gly Ile Thr Gly Pro Leu Pro 
                805                 810                 815     


Pro Glu Glu Arg Ala Pro Ala Glu Arg Leu Ala Thr Phe Ala Ala Pro 
            820                 825                 830         


Ala Lys Leu Leu Asp Arg Ile Glu Pro Trp His Ser Gln Phe Tyr Val 
        835                 840                 845             


Trp Leu Tyr Leu Ile Pro Ile Asp Glu Val Ala Leu Leu Arg His Gln 
    850                 855                 860                 


Leu Arg Lys Thr Val Ala Leu Glu Ala Lys Ser Gly Ile Gly Ser Gln 
865                 870                 875                 880 


Asp Ile Leu Ser Gln Val Asp Leu Leu Met Gly Leu Tyr Leu Ser Val 
                885                 890                 895     


Tyr Asp Ala Gly Phe Asp Gly Arg Glu His Val Gly Gly Leu Asn Ala 
            900                 905                 910         


Gly Lys Leu Phe Tyr Glu Ser Pro Gln Asp Phe Glu Lys Val Tyr Ser 
        915                 920                 925             


Asp Asp Gln Ser His His Glu Ile Ser Met Pro Gly Thr Arg Arg Gly 
    930                 935                 940                 


Leu Arg Gln Ile Leu Arg Met Asp His Phe Arg Ala Leu Glu Gly Ile 
945                 950                 955                 960 


Phe Glu Lys His Gln Val Thr Thr Asp Glu Val Lys Ala Phe Gln Gln 
                965                 970                 975     


Leu Lys Leu Thr Glu Val Gln Glu Ile Leu Glu Ser Lys Ile Arg Leu 
            980                 985                 990         


Gln Lys Ser Ile Ile Ser Met Ser  Lys Gln Ala Lys Leu  Asp Thr Glu 
        995                 1000                 1005             


Ala Leu  Arg Ser Glu Cys Gln  Lys Tyr Gln Val Ser  Ala Thr Lys 
    1010                 1015                 1020             


Leu Ala  Ile Tyr Asn Phe Gln  Val Lys Ala Ala Arg  Leu Ser Glu 
    1025                 1030                 1035             


His Ala  Arg Leu His Gln Leu  Met Met Arg Val Leu  Gly Arg Leu 
    1040                 1045                 1050             


Ala Asp  Phe Ser Met Met Trp  Glu Arg Asp Arg Gln  Tyr Leu Phe 
    1055                 1060                 1065             


Leu Gly  Leu Leu Tyr Arg Arg  Ile Gly Ala Glu Asn  Phe Ile Leu 
    1070                 1075                 1080             


His Arg  Met Ala Asp Glu Ile  Gly Ile Ala Leu Pro  Ala Asp Ala 
    1085                 1090                 1095             


Gly Leu  Gly Leu Val Ala Asp  Ala Gly Ala Ala Thr  Arg Arg Ser 
    1100                 1105                 1110             


Gly Ala  Ile Ser Asp Met His  Val Gln Ala Gly Phe  Leu Pro Leu 
    1115                 1120                 1125             


Trp Asp  Pro Asp Phe Gly Phe  Val Arg Glu Gly Asp  Gly Ala Glu 
    1130                 1135                 1140             


Leu Thr  Leu Leu Ala Val Gln  Asp Arg Glu Leu Phe  Met Arg Tyr 
    1145                 1150                 1155             


Phe Gly  Lys Leu Pro Glu Glu  Asn Pro Arg Asp Val  Arg Arg Arg 
    1160                 1165                 1170             


Glu Ala  Asn Glu Ala Glu Gly  Phe Ala Arg Pro Ser  Thr Lys Asn 
    1175                 1180                 1185             


Trp Asn  Gly Ser Phe Arg Leu  Pro Lys Arg Arg Ile  Arg Asn Asp 
    1190                 1195                 1200             


Phe Ala  His Phe Asn Val Ile  Ser Gly Lys Arg Arg  Pro Asn Leu 
    1205                 1210                 1215             


Thr Tyr  Leu Met Asn Ala Ile  Arg Ser Leu Met Ser  His Asp Arg 
    1220                 1225                 1230             


Lys Met  Lys Asn Ala Val Ser  Lys Ala Val Ala Glu  Ile Val Ala 
    1235                 1240                 1245             


Glu Glu  Gly Leu Glu Ile Arg  Trp Gln Val Arg Gly  Asp Arg Leu 
    1250                 1255                 1260             


Val Asp  Pro Thr Val Ile Pro  Met Leu Glu Ser His  Leu Thr Met 
    1265                 1270                 1275             


Val Arg  Pro Lys Asp Gly Phe  Asp Pro Arg Phe His  Leu Pro Gln 
    1280                 1285                 1290             


Ala Ser  Val Arg Phe Thr Ser  Met Val Lys Ala Leu  Phe Glu Phe 
    1295                 1300                 1305             


Asp Gln  Gly Gly Tyr Arg Glu  Thr Ile Pro Trp Lys  Glu Gly Lys 
    1310                 1315                 1320             


Lys Ala  Ser Arg Gly Gln Leu  Gly Tyr Pro Lys Glu  Phe Ile Ala 
    1325                 1330                 1335             


Arg Ile  Glu Gln Asp Glu Thr  Ile His Val Pro Arg  Glu Val Leu 
    1340                 1345                 1350             


Ala Gln  Arg Tyr Lys Gly Leu  Glu Gln Lys 
    1355                 1360             


<210>  543
<211>  1425
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  543

Met Lys Leu Ser Lys Val Asp Arg Ile Arg Val Ala Val Gly Lys Thr 
1               5                   10                  15      


Gly Lys Thr Glu Asn Gly Asn Ser Gln Gly Arg Gly Val Leu Tyr Arg 
            20                  25                  30          


Ser Pro Lys Gly Asn Lys Thr Val Ala Val Asp Ala Val Val Glu Glu 
        35                  40                  45              


Arg Ile Arg Asn Ala Asn Arg Leu Tyr Ser Ala Phe Phe Arg Cys Ala 
    50                  55                  60                  


Tyr Pro Glu Glu Pro Glu Arg His Phe Glu Glu Ile Ile Lys Arg Met 
65                  70                  75                  80  


Ala Thr Gly Lys Lys Ser Gly Ala Gln Ile Leu Lys Glu Tyr Ile Gly 
                85                  90                  95      


Tyr Glu Gly Gln Lys Asn Arg Lys Pro Tyr Thr Phe Tyr Val Asn Lys 
            100                 105                 110         


Cys Ala Tyr Arg Pro Ala Gly Lys Glu Leu Gly Gln Val Leu Arg Leu 
        115                 120                 125             


Phe Val Lys Glu Arg Leu Gly Gln Asn Trp Gln Asn Pro Glu Ala Ala 
    130                 135                 140                 


Glu Ala Ala Val Ala Leu Leu Thr Cys Leu Cys Glu Gly Lys Thr Asn 
145                 150                 155                 160 


Arg Tyr Thr Glu Asn Thr Ala Asp Gly Pro Val Leu Thr Glu Leu Ser 
                165                 170                 175     


Glu Gln Thr Val Thr Gln Leu Glu Gln Val Ser Arg Leu Gly Gly Ser 
            180                 185                 190         


Ile Leu Val Pro Lys Thr Glu Arg Leu Glu Thr Ile Val Thr Val Ile 
        195                 200                 205             


Leu Arg Leu Thr Ala Glu Gln Cys Asn Thr Ser Leu Tyr Val Asn Gly 
    210                 215                 220                 


Gly Thr Lys Glu Ala Gln Asp Ala Asp Leu Glu Lys Gln Ile Ala Leu 
225                 230                 235                 240 


Leu Lys Ser Leu Gln Thr Lys Pro Leu Leu Leu Lys Glu Arg Phe Asp 
                245                 250                 255     


Lys Val Thr Lys Gln Thr Ile Arg Asp Glu Gln Lys Leu Ser Glu Phe 
            260                 265                 270         


Ser Tyr Lys Asp Ala Thr Lys Glu Arg Met Glu Ala Val Val Val Arg 
        275                 280                 285             


Met Arg Lys Thr Leu Lys Lys Gly Ala Ser Arg Glu Val Ala Val Glu 
    290                 295                 300                 


Leu Leu Gln Ala Leu Ala Gln Tyr Asp Gly Lys Thr Trp Asp Gly Trp 
305                 310                 315                 320 


Leu Thr Gln Met Leu Glu Thr Glu Ala Ser Lys Lys Lys Leu Lys Asp 
                325                 330                 335     


Phe Ile Leu Ala Val Asn Lys Asp Phe His His Phe His Val Ile Lys 
            340                 345                 350         


Ser Val Lys Asn Thr Ala Val Ala Val Ser His Ser Glu Asp Asn Thr 
        355                 360                 365             


Leu Gln Leu Ser Gly Ala Lys Lys Lys Thr Lys Gly Ala Met Gln Asp 
    370                 375                 380                 


Ala Leu Phe Ala Tyr Ala Gln Ser Glu Glu Ser Ser Asp Glu Thr Leu 
385                 390                 395                 400 


His Arg Ile Lys Arg Ile Leu Phe Thr Tyr Val Leu Gly Gly Arg Gln 
                405                 410                 415     


Asp Asn Thr Leu Arg Leu Thr Glu Lys Thr His Leu Ala Lys Glu Leu 
            420                 425                 430         


Leu Trp Lys Phe Arg Gly Thr Gly Ala Gly Leu Phe Asp Ala Asp Phe 
        435                 440                 445             


Val Pro Glu Glu Glu Arg Ala Gly Glu Ser Gly Arg Lys Ala Gly Ser 
    450                 455                 460                 


Tyr Thr Asp Leu Gly Cys Leu Phe Ala Glu Asp Asp Gly Ile Arg Asn 
465                 470                 475                 480 


Gln Arg Arg Ile Ala Asp Arg Ile Asn Tyr Val Asn Tyr Gly Asn Tyr 
                485                 490                 495     


Leu Arg Met Arg Lys Ala Ala Glu Asp Glu Phe Thr Leu Phe Trp Cys 
            500                 505                 510         


Ala Tyr Ile Lys Asp Tyr Ile Glu Glu Asn Tyr Val Thr Lys Ile Arg 
        515                 520                 525             


Glu Ala Lys Arg Thr Gly Gly Lys Arg Arg Leu Lys Glu Thr Asp Cys 
    530                 535                 540                 


Glu Ala Glu Arg Met Met Glu Lys Cys Trp His Asp Ile Ile Arg Tyr 
545                 550                 555                 560 


Ile Cys Gly Lys Tyr Ile His Ile Gly Lys Ala Val Tyr His Phe Ala 
                565                 570                 575     


Ile Pro Glu Asp Leu Leu Ala Asn Pro Gly Glu Val Arg Ser Phe Gly 
            580                 585                 590         


Asp Val His Ala Lys Tyr Ala Asp Gly Ile Thr Ser Phe Asp Tyr Glu 
        595                 600                 605             


Asp Ile Lys Ala Glu Glu Asn Leu Gln Lys Ser Ile Phe Asn Val Leu 
    610                 615                 620                 


Val Ser Ala Val Ala Asn Tyr Ser Arg Ser Val Val Asp Leu Ser Ser 
625                 630                 635                 640 


Glu Arg Ala Glu Glu Leu Arg Arg Leu Pro Gly Asn Glu Arg Leu Asn 
                645                 650                 655     


Glu Asp Val Leu Met Met Lys Glu Thr His Leu Lys Glu Leu Leu Leu 
            660                 665                 670         


Pro Asp Ala Lys Lys Arg Leu Leu Arg Tyr Phe Gly Gly Tyr Ser Ala 
        675                 680                 685             


Cys Glu Gly Leu Ser Gly Val Thr Ser Glu Glu Leu Ala Trp Glu Met 
    690                 695                 700                 


Arg Thr Val Leu Ser Thr Leu Arg Asn Glu Ser Phe His Tyr Thr Phe 
705                 710                 715                 720 


Gly Lys Lys Lys Lys Leu Asp Tyr Lys Val Ala Lys Gln Leu Trp Met 
                725                 730                 735     


Gln Ala Ile Arg Ala Asn Arg Gln Leu Ile Leu Asp Lys Tyr Tyr Ser 
            740                 745                 750         


Asn Asn Thr Cys Arg Tyr Tyr Ser Pro Asn Ser Ile Lys Ala Leu Ile 
        755                 760                 765             


Glu Gln Gly Tyr Arg Ser Tyr Glu Glu Arg Glu Ala Gln Ile Pro Ala 
    770                 775                 780                 


Phe Lys Thr Val Trp Lys Lys Ala Glu Leu Ala Lys Tyr Leu Ala Asp 
785                 790                 795                 800 


Lys Lys Val Met Pro Ala Glu Ile Ser Gly Glu Glu Lys Glu Arg Val 
                805                 810                 815     


Ile Phe Gln Gly Ala Phe Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg 
            820                 825                 830         


Glu Phe Thr Val Gly Asn Thr Ala Ala Lys Tyr Phe Phe Asp Ala Val 
        835                 840                 845             


Glu Arg Tyr Cys Lys Glu Asn Glu Thr Gly Pro Tyr Lys Asn Pro Ala 
    850                 855                 860                 


Lys Ser Phe Asn Asp Tyr Val Asn Gly Ala Phe Asn Asn Lys Gly Val 
865                 870                 875                 880 


Lys Val Gln Lys Gly Leu Ser Asp Leu Tyr Arg Glu Gly Lys Ile Thr 
                885                 890                 895     


Phe Gly Val Val Cys Gln Thr Ile Met Ala Glu Tyr Thr Gln Gln Asn 
            900                 905                 910         


Glu Lys Ser Glu Gly Glu Ala Ile Tyr Gln His Phe Lys Met Leu Phe 
        915                 920                 925             


Pro Leu Cys Met Arg Lys Gly Phe Gln Lys Tyr Val Glu Glu Lys His 
    930                 935                 940                 


Lys Glu Leu Leu Gln Pro Val Ile Arg Glu Met Gly Ser Arg Glu Asp 
945                 950                 955                 960 


Phe Leu Thr Asn Ile His Ile Gly Cys Phe Asp Asp Phe Cys Arg Glu 
                965                 970                 975     


Asp Gly Met Tyr Glu Tyr Asp Trp Phe Val Val Ala His Leu Ile His 
            980                 985                 990         


Pro Lys Arg Leu Asn Glu Leu Val  Gly Asn Leu Lys Asp  Tyr Met Gln 
        995                 1000                 1005             


Phe Lys  Gln Asp Ile Leu Arg  Arg Ala Asp Tyr Val  Glu Gln Phe 
    1010                 1015                 1020             


Thr Lys  Glu Glu Leu Ala Ala  Met Lys Ala Arg Thr  Glu Glu Lys 
    1025                 1030                 1035             


Leu Gln  Lys Ile Ser Gly Ile  Leu Arg Val Ala Glu  Phe Val Arg 
    1040                 1045                 1050             


Gly Ile  Ala Gly Arg Val Ser  Asn Thr Phe Ser Asp  Tyr Tyr Glu 
    1055                 1060                 1065             


Ser Glu  Glu Ala Tyr Ala Ser  Tyr Leu Glu Gln Tyr  Ile Glu Phe 
    1070                 1075                 1080             


Pro Arg  Ile Lys Gly Ser Thr  Val Phe Glu Ser Phe  Arg Asp Phe 
    1085                 1090                 1095             


Cys Val  Asn Thr Leu Pro Gly  Gly Ala Val Met Asp  Val Tyr Met 
    1100                 1105                 1110             


Asp Glu  Lys Asn Pro Arg Ile  Leu Arg Asn Val Glu  Val Ala Arg 
    1115                 1120                 1125             


Met Tyr  Ala Gly Gly Asp Ile  Gly Leu Arg Thr Arg  Lys Lys Val 
    1130                 1135                 1140             


Thr Ala  Glu Glu Leu Lys Arg  Tyr Tyr Gln Asn Glu  Ala Glu Val 
    1145                 1150                 1155             


Ala Ala  Leu Leu Lys Ala Gly  Leu Cys Ala Thr Ala  Glu Asp Gln 
    1160                 1165                 1170             


Lys Arg  Val Lys Ala Gln Gln  Glu Leu Arg Asn Arg  Ile Thr Leu 
    1175                 1180                 1185             


Thr Asp  Val Thr Glu Ile Gln  Glu Val Ile Asn Asp  Leu Leu Ser 
    1190                 1195                 1200             


Gln Leu  Val Thr Phe Ser Tyr  Phe Arg Glu Arg Asp  Glu Met Tyr 
    1205                 1210                 1215             


Leu Leu  Leu Gly Phe Tyr Tyr  Met Ala Leu Gln Ser  Asp Gly Asp 
    1220                 1225                 1230             


Trp Gly  Glu Glu Leu Arg Val  Phe Asp Gly Lys Lys  Leu Gln Val 
    1235                 1240                 1245             


Glu Asn  Gly Phe Val Leu Tyr  Gln Leu Leu Ser Ala  Phe Thr Tyr 
    1250                 1255                 1260             


Gly Leu  Asn Met Tyr Ser Glu  Ala Ala Pro Asp Gly  Lys Gly Gly 
    1265                 1270                 1275             


Ser Gln  Ala Gly Lys Ile Gly  Glu Phe Ile Lys Ala  His Pro Asn 
    1280                 1285                 1290             


Ser Trp  Asp Arg Ala Leu Arg  Leu Phe Val Asp Asp  Gly Ala Cys 
    1295                 1300                 1305             


Glu Glu  Val Ser Arg Lys Ala  Arg Asn Tyr Val Asp  His Phe Arg 
    1310                 1315                 1320             


Tyr Tyr  Val Lys Pro Asp Arg  Ser Ile Met Asp Leu  Tyr Ala Val 
    1325                 1330                 1335             


Tyr His  Glu Tyr Phe Phe Asp  Tyr Ser Thr Lys Met  Arg Lys Ser 
    1340                 1345                 1350             


Val Leu  Gln Asn Phe Ala Ser  Ile Leu Glu Arg Tyr  Phe Val Leu 
    1355                 1360                 1365             


Thr Lys  Phe Lys Leu Gly Gly  Glu Arg Gly Ala Gln  Thr Leu Glu 
    1370                 1375                 1380             


Ala Glu  Leu Ser Gly Asp Lys  Phe Thr Tyr Lys Leu  Ser Asp Thr 
    1385                 1390                 1395             


Lys Ala  Lys Pro Val Val Leu  Pro Ala Arg Asn Lys  Glu Phe Leu 
    1400                 1405                 1410             


Glu Asn  Leu Lys Asn Glu Leu  Asn Tyr Arg Gln Glu  
    1415                 1420                 1425 


<210>  544
<211>  1334
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  544

Met Gly Asn Leu Phe Gly Tyr Lys Lys Trp Tyr Lys Val Asp Lys Ile 
1               5                   10                  15      


Ile Lys Asp Lys Lys Gly Lys Lys Ser Thr Ile Lys Gln Glu Val Arg 
            20                  25                  30          


Ile Lys Arg Asn Tyr Leu Thr Asn Arg Tyr Ile Leu Asn Thr Asn Asn 
        35                  40                  45              


Lys Asp Lys Asn Asn Ile Asn Asn Glu Asp Phe Val Asp Gln Phe Ile 
    50                  55                  60                  


Glu Tyr Lys Thr Lys Asn Asp Ile Phe Glu Lys Phe Thr Arg Lys Phe 
65                  70                  75                  80  


His Met Gly Asn Ile Leu Phe Lys Leu Lys Gly Asn Lys Arg Ser Ile 
                85                  90                  95      


Glu Asp Ser Asn Asp Phe Leu Lys Thr Glu Glu Val Val Leu Asp Lys 
            100                 105                 110         


Glu Ile Tyr Gly Gln Ser Glu Lys Leu Arg Asn Glu Lys Gly Ile Thr 
        115                 120                 125             


Lys Gln Gly Ile Leu Lys Glu Ile Ile Asp Lys Gly Ile Asn Glu Ser 
    130                 135                 140                 


Asn Asp Ser Ile Leu Ile Lys Thr Lys Phe Gly Lys Glu Ile Lys Ile 
145                 150                 155                 160 


Asn Phe Thr Asp Glu Ser Lys Lys Asn Lys Asn Glu Tyr Gln Ile Thr 
                165                 170                 175     


Leu Lys Val Ile Pro Glu Asn Glu Leu Lys Ile Lys Arg Glu Val Tyr 
            180                 185                 190         


Asp Val Phe Lys Met Ile Asn Met Asp Leu Tyr Gln Ile Ile Lys Glu 
        195                 200                 205             


Ile Ile Glu Asn Glu Val Gln Lys Val Phe Lys Asn Arg Tyr Tyr Glu 
    210                 215                 220                 


Glu Tyr Leu Arg Glu Lys Leu Leu Glu Asp Asn Gln Ile Asn Val Ile 
225                 230                 235                 240 


Leu Thr Asn Phe Met Lys Ile Arg Glu Lys Thr Lys Ser Asn Ser Glu 
                245                 250                 255     


Ile Met Gly Phe Val Lys Phe Tyr Leu Asn Val Gly Gly Asp Lys Lys 
            260                 265                 270         


Lys Ser Glu Asn Lys Lys Met Phe Val Glu Lys Ile Leu Asn Ile Asn 
        275                 280                 285             


Val Asp Leu Thr Glu Glu Asp Ile Val Asp Phe Ile Val Lys Glu Leu 
    290                 295                 300                 


Lys Phe Tyr Gly Ile Ile Lys Arg Ile Glu Lys Leu Gln Glu Lys Lys 
305                 310                 315                 320 


Ala Asp Arg Thr Asp Lys Asp Ile Lys Lys Thr Tyr Ile Asn Thr Tyr 
                325                 330                 335     


Val Ser Leu Asp Lys His Glu Lys Phe Lys Lys Tyr Asn Arg Asn Lys 
            340                 345                 350         


Lys Asp Thr Ile Val Lys Ser Phe Ile Lys Asp Ile Lys Asp Asn Thr 
        355                 360                 365             


Met Lys Gln Lys Ile Asn Gln Ile Leu Arg Lys Phe Lys Ile Glu Glu 
    370                 375                 380                 


Leu Ile Asn Lys Leu Arg Ile Glu Asn Lys Asn Phe Asp Thr Glu Ile 
385                 390                 395                 400 


Phe Arg Ile Phe Lys Glu His Tyr Gln Glu Ile Phe Asn Ser Glu Lys 
                405                 410                 415     


Phe Glu Glu Lys Ser Asp Glu Glu Lys Glu Leu Tyr Lys Ile Ile Tyr 
            420                 425                 430         


Arg Tyr Leu Lys Gly Arg Ile Glu Lys Ile Leu Ile Asn Glu Gln Lys 
        435                 440                 445             


Val Arg Leu Lys Lys Met Glu Lys Ile Glu Val Glu Lys Ile Leu Asn 
    450                 455                 460                 


Glu Ser Ile Leu Ser Glu Lys Ile Leu Lys Arg Val Lys Gln Tyr Thr 
465                 470                 475                 480 


Leu Glu His Val Met Tyr Leu Gly Lys Leu Val His Asn Asp Ile Asp 
                485                 490                 495     


Arg Ser Ile Val Asn Thr Asn Asp Phe Ser Arg Leu His Ala Lys Glu 
            500                 505                 510         


Glu Leu Asp Leu Glu Leu Ile Thr Phe Phe Ala Ser Thr Asn Met Glu 
        515                 520                 525             


Leu Asn Lys Ile Phe Ser Arg Glu Asn Ile Asn Asn Asp Glu Asn Ile 
    530                 535                 540                 


Asp Phe Phe Gly Gly Asp Arg Glu Lys Asn Tyr Val Leu Asp Lys Lys 
545                 550                 555                 560 


Asn Leu Asn Ser Lys Ile Glu Ile Ile Arg Asp Leu Asp Phe Ile Asp 
                565                 570                 575     


Asn Lys Asn Ser Ile Thr Asn Asn Phe Ile Ser Lys Phe Thr Lys Ile 
            580                 585                 590         


Gly Thr Asn Glu Arg Asn Arg Ile Leu His Ala Ser Ser Lys Glu Arg 
        595                 600                 605             


Asp Leu Gln Gly Thr Gln Asp Asp Tyr Asn Lys Val Ile Asn Ile Ile 
    610                 615                 620                 


Gln Asn Leu Lys Ile Ser Asp Glu Glu Val Ser Lys Ala Leu Asn Leu 
625                 630                 635                 640 


Asp Val Val Phe Lys Asp Lys Lys Asn Ile Ile Thr Lys Ile Asn Asp 
                645                 650                 655     


Ile Glu Ile Ser Glu Glu Asn Asn Ser Ile Ile Lys Tyr Leu Pro Ser 
            660                 665                 670         


Phe Ser Lys Val Leu Pro Glu Ile Leu Asn Leu Tyr Lys Asn Lys Asn 
        675                 680                 685             


Lys Asn Asn Pro Phe Asp Thr Thr Glu Thr Glu Arg Ile Met Leu Asn 
    690                 695                 700                 


Ala Leu Ile Tyr Val Asn Lys Glu Leu Tyr Lys Lys Leu Ile Leu Glu 
705                 710                 715                 720 


Lys Asn Leu Glu Glu Asn Glu Ser Lys Asn Lys Phe Leu Lys Glu Leu 
                725                 730                 735     


Lys Lys Asn Leu Gly Gly Thr Asp Glu Ile Asp Glu Asn Ile Ile Glu 
            740                 745                 750         


Ser Tyr Tyr Lys Asn Thr Gln Ile Ser Ala Ser Lys Gly Asn Asn Lys 
        755                 760                 765             


Ala Ile Lys Lys Tyr Gln Lys Lys Ile Ile Glu Cys Tyr Ile Lys Tyr 
    770                 775                 780                 


Leu Glu Glu Asn Tyr Arg Glu Leu Phe Asp Phe Ser Asp Phe Lys Met 
785                 790                 795                 800 


Asn Ile Gln Glu Ile Lys Lys Gln Ile Lys Glu Ile Asn Asp Asn Lys 
                805                 810                 815     


Thr Tyr Lys Arg Ile Thr Ile Lys Thr Ser Asp Lys Ser Ile Val Ile 
            820                 825                 830         


Asn Asn Asp Phe Glu Tyr Ile Ile Ser Ile Phe Ala Leu Leu Asn Asn 
        835                 840                 845             


Asn Ile Phe Ile Asn Lys Ile Arg Asn Arg Phe Phe Ser Thr Ser Val 
    850                 855                 860                 


Trp Leu Asn Thr Ser Glu Tyr Gln Asn Ile Ile Asp Ile Leu Asp Glu 
865                 870                 875                 880 


Ile Met Gln Lys Lys Leu Glu Lys Ile Val Ile Phe Val Asp Lys Thr 
                885                 890                 895     


Lys Phe Glu Ile Asp Lys Lys Ser Asn Ile Leu Gln Asp Glu Gln Arg 
            900                 905                 910         


Lys Leu Ser Asn Ile Asn Lys Lys Asp Leu Lys Lys Lys Val Asp Gln 
        915                 920                 925             


Tyr Ile Lys Asp Lys Asp Gln Glu Ile Lys Asp Lys Asp Gln Glu Ile 
    930                 935                 940                 


Lys Ser Lys Ile Leu Cys Arg Ile Ile Phe Asn Ser Asp Phe Leu Lys 
945                 950                 955                 960 


Lys Tyr Lys Lys Glu Ile Asp Asn Leu Val Glu Ser Thr Glu Pro Lys 
                965                 970                 975     


Asn Glu Asn Lys Phe Gly Lys Ile Tyr Tyr Pro Glu Glu His Lys Asn 
            980                 985                 990         


Glu Leu Tyr Ile Tyr Lys Lys Asn  Leu Phe Leu Asn Ile  Gly Asn Pro 
        995                 1000                 1005             


Asn Phe  Asp Lys Ile Tyr Arg  Ile Ile Ser Glu Asp  Ile Lys Asn 
    1010                 1015                 1020             


Val Asn  Thr Glu Ile Leu Phe  Asp Asn Asp Ile Arg  Asn Asn Lys 
    1025                 1030                 1035             


Ile Ala  Lys Ile Asp Val Ile  Leu Lys Asn Leu Asn  Asp Lys Leu 
    1040                 1045                 1050             


Asn Gly  Tyr Ser Gln Gly Tyr  Lys Glu Lys Tyr Ile  Glu Lys Leu 
    1055                 1060                 1065             


Lys Glu  Asn Ser Asp Phe Phe  Thr Lys Asn Ile Gln  Asn Glu Asn 
    1070                 1075                 1080             


Tyr Asn  Ser Phe Lys Glu Phe  Glu Glu Asp Tyr Asn  Lys Val Ser 
    1085                 1090                 1095             


Glu Tyr  Lys Lys Thr Arg Asp  Leu Val Glu Phe Asn  Tyr Leu Asn 
    1100                 1105                 1110             


Lys Ile  Glu Asn Tyr Leu Ile  Asp Ile Asn Trp Lys  Leu Ala Ile 
    1115                 1120                 1125             


Gln Met  Ala Arg Phe Glu Arg  Asp Met His Tyr Ile  Val Asn Gly 
    1130                 1135                 1140             


Leu Lys  Glu Leu Asn Phe Ile  Asn Leu Asn Gly Tyr  Asn Ala Gly 
    1145                 1150                 1155             


Ile Ser  Arg Ala Tyr Pro Lys  Tyr Asn Asp Ser Asp  Ser Asn Lys 
    1160                 1165                 1170             


Asn Cys  Lys Lys Phe Tyr Glu  Thr Thr Ala Tyr Tyr  Lys Phe Phe 
    1175                 1180                 1185             


Asp Asp  Lys Ser Tyr Arg Glu  Phe Glu Asp Ile Cys  Tyr Glu Phe 
    1190                 1195                 1200             


Gly Ile  Asp Leu Arg Lys Asn  Ser Asn Ile Gln Ala  Lys Glu Glu 
    1205                 1210                 1215             


Arg Asn  Ile Arg Asn Tyr Ile  Ser His Phe Tyr Ile  Val Arg Asn 
    1220                 1225                 1230             


Pro Phe  Val Asp Tyr Ser Ile  Ala Glu Gln Ile Asp  Arg Val Ser 
    1235                 1240                 1245             


Asp Leu  Leu Ser Tyr Ser Thr  Arg Tyr Asn Asn Ser  Thr Tyr Ala 
    1250                 1255                 1260             


Ser Val  Phe Glu Val Phe Lys  Lys Asp Val Asp Leu  Glu Tyr Asp 
    1265                 1270                 1275             


Glu Leu  Lys Lys Lys Phe Lys  Leu Ile Gly Asn Thr  Asp Ile Leu 
    1280                 1285                 1290             


Lys Arg  Leu Met Lys Pro Lys  Lys Val Ser Val Leu  Glu Leu Glu 
    1295                 1300                 1305             


Ser Tyr  Asn Ser Asn Tyr Ile  Lys Asn Leu Ile Ile  Glu Leu Leu 
    1310                 1315                 1320             


Thr Lys  Val Glu Asn Lys Asp  Glu Ile Phe Ser 
    1325                 1330                 


<210>  545
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  545

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Leu Gly Thr Asp Thr 
            20                  25                  30          


Ile Gly Leu Lys Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Asp Lys Pro Lys Lys 
    50                  55                  60                  


Trp Lys Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Glu Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Ser Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Met Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Tyr Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ser Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Lys Asp Arg Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Lys Glu Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Gln Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Phe 
            660                 665                 670         


Ile Arg Lys Asn Phe Pro Glu Asp Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Asp Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asn Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ser 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Asp Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Asp Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asn  Ser Glu Lys Lys Glu  Ala Tyr Gln Lys Ile  Glu Val Asn 
    1100                 1105                 1110             


Gly Asp  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Val  Tyr Ala Pro Asp Glu  Lys Gly Asp 
    1130                 1135                 1140             


Ile Leu  Lys Glu Gln Cys Thr  Lys Gly Gly Ala Gly  Gly Lys Ile 
    1145                 1150                 1155             


Ser Ala  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Lys Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Lys Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Lys Gln 
    1250                 1255                 1260             


Thr Thr  Ser Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Ser Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Lys  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Val Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Gly Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Pro Asn 
    1370                 1375                 1380         


<210>  546
<211>  1432
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  546

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Phe Glu Asn Lys Ser Glu Glu Gln Phe Ser Lys Gln Ser Phe Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Lys Lys Asn Gly Lys Val Arg Leu Lys Ser Asn Asp 
        35                  40                  45              


Leu Arg Lys His Val Met Asp Cys Asn Lys Asn Ala Gln Asn Leu Tyr 
    50                  55                  60                  


Asn Val Ile Asn Pro Glu Phe Asp Phe Cys Lys Asp Lys Asn Arg Lys 
65                  70                  75                  80  


Lys Val Phe Glu Asp Leu Ala Lys Asn Phe Asn Leu Val Leu Cys Ser 
                85                  90                  95      


Ala Leu Arg Ser Val Asp Thr Ser Ile Ser Asp Pro Lys Glu Arg Ala 
            100                 105                 110         


Lys Glu Glu Thr Ala Phe Ile Leu Asn Met Asp Lys Glu Gly Ile Lys 
        115                 120                 125             


Thr Lys Lys Asp Ser Met Lys Ser Glu Asn Leu Ile Val Glu Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Asp Asn Gly Thr Glu Lys Thr Lys Lys Ala Glu Ser 
145                 150                 155                 160 


Pro Glu Leu Lys Glu Gln Arg Arg Lys Glu Gln Glu Ala Glu Ile Leu 
                165                 170                 175     


Lys Met Thr Glu Glu Leu Val Leu Arg Lys Leu Lys Lys Thr Leu Arg 
            180                 185                 190         


Arg Asn Ala Thr Leu Asp Asp Glu Ser Lys Met Gln Met Thr Glu Ile 
        195                 200                 205             


Ala Ile Ser Leu Met Lys Ala Ile Cys Val His Gly Asn Ala Gly Ser 
    210                 215                 220                 


Phe Asp Pro Val Ile Leu Lys Thr Phe Phe Lys Glu Ile Asp Lys Asp 
225                 230                 235                 240 


Tyr Met Lys Asn Glu Gln Met Glu Glu Ile Val Arg Ser Ile Glu Ser 
                245                 250                 255     


Gln Ser Val Lys Val Lys Val Ala Glu Lys Asp Gly Lys Tyr Leu Leu 
            260                 265                 270         


Leu Pro Ala Asn Ala Asp His Arg Lys Lys Lys Tyr Ala Phe Glu Phe 
        275                 280                 285             


Met Arg Lys Tyr Ala Ala Ala Glu Ala Glu Gly Lys Gln Glu Leu Thr 
    290                 295                 300                 


Glu His Ile Gln Ala Leu Ile Gly Leu Tyr Leu Cys Gly Glu Ser Glu 
305                 310                 315                 320 


Tyr Gln Asp Ala Lys Asn Cys Phe Tyr Asp Met Val Glu Asn His Glu 
                325                 330                 335     


Cys Met Ser Gly Glu Ile Glu Glu Ile Cys Asn Thr Ile Glu Glu Leu 
            340                 345                 350         


Lys Asn Leu Ser Arg Gln Lys Arg Glu Glu Arg Lys Glu Ile Lys Glu 
        355                 360                 365             


Lys Ile Arg Lys Ile Glu Lys Ser Gly Lys Gly Asp Lys Arg Thr Pro 
    370                 375                 380                 


Asn Asn Asn Ser Asn Lys Ser Tyr Lys Asn Asp Lys Lys Asp Asn Asp 
385                 390                 395                 400 


Asn Lys Glu Asn Asp Ile Asn Leu Asn Glu Asn Asp Leu Lys Lys Ala 
                405                 410                 415     


Ile Glu Glu Ile Asp Lys Glu Leu Ala Lys Ile Pro Leu Glu Ile Cys 
            420                 425                 430         


Ile Asn Asn Glu Lys Leu Asn Asn Ala Val Ile Lys Thr Met Ser Val 
        435                 440                 445             


Lys Tyr Arg Ala Ala Val Lys Tyr Leu Val Ser Lys Val Lys Lys Thr 
    450                 455                 460                 


Val Leu Gly Glu Ile Lys Glu Lys Lys Asp Cys Ser Cys Ala Asp Leu 
465                 470                 475                 480 


Tyr Trp Ile Asp Tyr Ile Asp Asn Thr Val Lys Lys Leu Leu Leu Asp 
                485                 490                 495     


Ser Arg Asn Lys Gly Met Tyr Arg Tyr Glu Ile Ser Phe Leu Ser Asn 
            500                 505                 510         


His Ile Trp Lys Glu Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu 
        515                 520                 525             


Leu Gly Lys Gly Val Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Ala 
    530                 535                 540                 


Leu Glu Gly Lys Pro Val Ser Val Cys Glu Val Lys Pro Glu Tyr Arg 
545                 550                 555                 560 


Lys Gly Ile Ser Gly Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Ser 
                565                 570                 575     


Leu Asp Arg Glu Met Glu Glu Tyr Val Leu Phe Ala Val Asn Asn Phe 
            580                 585                 590         


Ala Arg Ala Ala Ala Pro Glu Asn Glu Arg Glu Lys Pro Gly His Glu 
        595                 600                 605             


Asp Val Leu Ile Met Lys Thr Ser Asp Glu Leu Ile Ala Glu Asn Lys 
    610                 615                 620                 


Lys Asn Gln Glu Pro Ile Val Leu Tyr Lys Asp Ala Asp Arg Arg Ile 
625                 630                 635                 640 


Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg Glu Lys Glu Asp Ser 
                645                 650                 655     


Phe Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr Lys Glu Ile Arg Asn 
            660                 665                 670         


Glu Leu Tyr Thr Val Arg Asn Ile Thr Phe His Tyr Thr Thr Lys Ala 
        675                 680                 685             


Glu Lys Asp Gln Ile Gln Lys His Glu Met Ala Glu Tyr Phe Phe Lys 
    690                 695                 700                 


Glu Glu Leu Ala Asp Ile Ser Gly Val Phe Arg Lys Lys Tyr Tyr Ser 
705                 710                 715                 720 


Asn Asn Val Trp Lys Phe Tyr Asp Val Glu Val Ile Asn Asp Leu Met 
                725                 730                 735     


Asp Lys Ile Tyr Ser Gly Arg Lys Tyr Arg Ala Ala Gln Ile Pro Ala 
            740                 745                 750         


Phe Asn Lys Ile Ile Ser Arg Pro Ala Leu Pro Gln Ile Ile Asn Gly 
        755                 760                 765             


Phe Val Lys Gly Asn Ser Leu Lys Lys Ile Met Asn Tyr Pro Asp Arg 
    770                 775                 780                 


Glu Ile Ile Lys Gln Tyr Trp Ser Ala Leu Phe Phe Val Leu Lys Glu 
785                 790                 795                 800 


Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Glu Asn Leu Glu Glu Asn 
                805                 810                 815     


Ile Arg Glu Arg Phe Leu Arg Val Leu Ala Arg Lys Leu Glu Glu Thr 
            820                 825                 830         


Ser Asp Ala Lys Glu Gln Lys Ala Trp Glu Ser Phe Asp Lys Arg Ile 
        835                 840                 845             


Ser Glu Ile Gly Arg Glu Arg Ser Phe Gly Glu Ile Cys Gln Gly Leu 
    850                 855                 860                 


Met Ile Glu Tyr Met Leu Gln Asn Asn Asp Ser Pro Met Val Arg Lys 
865                 870                 875                 880 


Glu Asn Ile His Lys Arg Thr Lys Ser Arg Asp Thr Gln Ile Tyr Lys 
                885                 890                 895     


His Tyr Arg Thr Leu Leu Tyr Ile Cys Ile Arg Asp Ala Phe Ile Glu 
            900                 905                 910         


Tyr Leu Lys Glu Lys Trp Gln Gly Leu Arg Glu Pro Val Leu Ile Lys 
        915                 920                 925             


Lys Glu Trp Ser Glu Glu Glu Phe Cys His Ser Asp Asn Val Glu His 
    930                 935                 940                 


Leu Ser Leu Tyr Asp His Leu Lys Asp Leu Phe His Ser Thr Ala Ser 
945                 950                 955                 960 


Gly Pro Ser Trp Tyr Ile Ala Ala His Phe Ile Asn Pro Lys Tyr Leu 
                965                 970                 975     


Asn His Leu Ile Gly Ser Ile Arg Asn Tyr Leu Gln Phe Thr Glu Asp 
            980                 985                 990         


Ile Glu Arg Arg Ala Val Ser Leu  Gly Lys Cys Val Asp  Asn Glu Arg 
        995                 1000                 1005             


Glu Glu  Lys Asn Leu Arg Tyr  Arg Asn Thr Leu Glu  Ile Leu Glu 
    1010                 1015                 1020             


Phe Val  Leu Gln Phe Cys Gly  Lys Thr Thr Lys Val  Met Glu Asp 
    1025                 1030                 1035             


Tyr Phe  Glu Ser Asn Glu Val  Tyr Ala Ala Tyr Leu  Ser Asp Phe 
    1040                 1045                 1050             


Val Asp  Tyr Lys Thr Pro Lys  Asn Ile Thr Asp Ile  Glu Thr Ala 
    1055                 1060                 1065             


Leu His  Ile Phe Cys Glu Gln  Lys Val Asn Val Asp  Gly Lys Glu 
    1070                 1075                 1080             


Asn Met  Val Gly Ile Tyr Tyr  Asp Gly Gly Asn Leu  Ile Pro Asn 
    1085                 1090                 1095             


Arg Asn  Ile Ile Arg Ala Asn  Met Tyr Gly Asn Val  Ser Cys Leu 
    1100                 1105                 1110             


Lys Ala  Ser Met Asp Lys Ile  Lys Tyr Ala Glu Ile  Arg Lys Met 
    1115                 1120                 1125             


Tyr Ile  Asp Lys Ser Lys Leu  Asp Ser Val Leu Lys  Glu Gly Val 
    1130                 1135                 1140             


Cys Arg  Thr Lys Glu Asp Gln  Lys Ala Leu Arg Glu  Phe Gln Asn 
    1145                 1150                 1155             


Glu Lys  Asn Arg Ile Glu Leu  Leu Asp Leu Ser Thr  Tyr Thr Glu 
    1160                 1165                 1170             


Ile Leu  Asn Asp Met Gln Ala  Ile Leu Ile Gly Trp  Thr Tyr Met 
    1175                 1180                 1185             


Arg Glu  Arg Asp Leu Met Tyr  Tyr Gln Leu Gly Tyr  Tyr Tyr Thr 
    1190                 1195                 1200             


Lys Leu  Phe Trp Thr Asp Ser  Ile Ser Glu Glu Asp  Glu Arg Arg 
    1205                 1210                 1215             


Arg Leu  Thr Gly Asp Glu Ile  Asn Ile Glu Asp Gly  Ala Ile Leu 
    1220                 1225                 1230             


Tyr Gln  Ile Leu Ala Leu Asn  Thr Tyr His Leu Pro  Val Ile Ser 
    1235                 1240                 1245             


Asn Lys  Lys Asn Thr Val Ser  Phe Val Lys Asp Asn  Gly Ser Ile 
    1250                 1255                 1260             


Gly Gly  Lys Ala Leu Arg Ala  Phe Phe Arg Asn Phe  Glu Asn Ala 
    1265                 1270                 1275             


Ile Pro  Ile Tyr Leu Glu Gly  Leu Ser Leu Phe Glu  Asn Thr Asp 
    1280                 1285                 1290             


Glu His  Asp Asp Ile Ile Asp  Thr Arg Asn Tyr Ile  Glu His Phe 
    1295                 1300                 1305             


Lys Tyr  Phe Ile Lys Ser Asp  Arg Ser Met Met Asp  Leu Tyr Ser 
    1310                 1315                 1320             


Glu Val  Tyr Asp Arg Phe Phe  Arg His Asp His Arg  Leu Lys Lys 
    1325                 1330                 1335             


Ser Val  Pro Glu Val Leu Ile  Asn Val Leu Ala Arg  Asn Phe Met 
    1340                 1345                 1350             


Asp Ala  Arg Ile Tyr Met Lys  Leu Gly Ser Lys Gln  Val Val Lys 
    1355                 1360                 1365             


Glu Lys  Thr Gly Val Ser Arg  Glu His Lys Ala Ser  Lys Ile Ala 
    1370                 1375                 1380             


Phe Thr  Asp Lys Gly Ile Glu  Ser Thr Ala Leu Thr  Tyr Thr Ile 
    1385                 1390                 1395             


Lys Pro  Asp Ser Lys Asp Asn  Lys Lys Glu Ala Lys  Ile Leu Val 
    1400                 1405                 1410             


Asp Ala  Arg Ser Glu Val Phe  Leu Lys Gln Phe Gln  Lys Ile Leu 
    1415                 1420                 1425             


Glu Tyr  Arg Ile 
    1430         


<210>  547
<211>  1407
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  547

Met Gly Asn Leu Phe Gly Tyr Lys Lys Trp Tyr Lys Val Asp Lys Ile 
1               5                   10                  15      


Ile Lys Asp Lys Lys Gly Lys Lys Ser Thr Ile Lys Gln Glu Val Arg 
            20                  25                  30          


Ile Lys Arg Asp Tyr Leu Thr Asn Arg Tyr Ile Leu Asn Thr Asn Asn 
        35                  40                  45              


Lys Asp Lys Asn Asn Ile Asn Asn Lys Asp Phe Val Asn Gln Phe Ile 
    50                  55                  60                  


Glu Tyr Lys Thr Lys Asn Asp Ile Phe Glu Lys Phe Thr Arg Lys Phe 
65                  70                  75                  80  


His Met Gly Asn Ile Leu Phe Lys Leu Lys Ala Lys Glu Ser Val Gly 
                85                  90                  95      


Glu Ile Arg Ser Tyr Asn Asn Phe Leu Glu Lys Glu Lys Ala Ile Leu 
            100                 105                 110         


Glu Ile Glu Ile Tyr Gln Gln Ser Glu Glu Leu Arg Lys Lys Glu Asn 
        115                 120                 125             


Ile Thr Lys Lys Asp Ile Ile Asp Lys Val Ile Glu Asp Lys Ile Thr 
    130                 135                 140                 


Glu Asn Ser Asn Glu Ile Lys Met Gln Ile Lys Leu Glu Lys Asn Asn 
145                 150                 155                 160 


Phe Glu Glu Ile Arg Ile Tyr Ile Asn Lys Glu Leu Gly Gln Tyr Asn 
                165                 170                 175     


Ile Lys Leu Lys Asn Ile Asp Asn Asp Glu Leu Asn Leu Lys Arg Glu 
            180                 185                 190         


Thr Tyr Glu Ile Leu Lys Ser Ile Asn Ala Asn Leu Tyr Ile Ile Thr 
        195                 200                 205             


Lys Asn Ala Ile Ser Asn Ala Asn Phe Glu Lys Arg Asn Tyr Glu Ile 
    210                 215                 220                 


Phe Leu Lys Lys Ser Met Arg Lys Tyr Leu Arg Glu Asn Ile Asn Lys 
225                 230                 235                 240 


Lys Leu Arg Asn Thr Phe Leu Glu Ser Leu Ser Lys Ser Leu Lys Lys 
                245                 250                 255     


Ile Gln Asn Asn Ile Arg Glu Asn Glu Glu Ile Ile Asn Phe Ile Lys 
            260                 265                 270         


Tyr Tyr Ser Ser Ile Asn Gly Asn Lys Thr Val Ser Glu Asn Lys Lys 
        275                 280                 285             


Thr Phe Leu Glu Lys Ile Leu Asn Thr Glu Val Ser Ile Ser Glu Asn 
    290                 295                 300                 


Asp Ile Ile Asp Phe Ile Ile Gly Glu Leu Lys Phe Tyr Gly Ile Ile 
305                 310                 315                 320 


Lys Arg Ile Glu Glu Leu Gln Glu Lys Thr Ile Asp Arg Thr Glu Glu 
                325                 330                 335     


Asp Ile Lys Asn Thr Tyr Ile Asn Thr Tyr Val Ser Leu Asp Lys His 
            340                 345                 350         


Glu Lys Phe Lys Ile Asp Arg Glu Asn Lys Lys Asp Lys Val Val Lys 
        355                 360                 365             


Leu Phe Val Lys Asp Ile His Asn Asn Thr Met Glu Glu Lys Ile Asn 
    370                 375                 380                 


Asp Ile Leu Ser Lys Phe Lys Ile Lys Glu Leu Thr Lys Lys Leu Glu 
385                 390                 395                 400 


Lys Asn Thr Glu Asn Lys Asn Phe Asp Thr Glu Ile Phe Gly Ile Phe 
                405                 410                 415     


Lys Lys His Tyr Lys Val Asn Phe Asp Ser Lys Lys Phe Ser Asn Lys 
            420                 425                 430         


Ser Asp Glu Glu Lys Glu Leu Tyr Lys Ile Ile Tyr Arg Tyr Leu Lys 
        435                 440                 445             


Gly Arg Ile Glu Lys Ile Leu Ile Asn Glu Glu Lys Val Arg Leu Lys 
    450                 455                 460                 


Lys Met Glu Lys Ile Glu Ile Glu Lys Ile Leu Asn Glu Ser Ile Leu 
465                 470                 475                 480 


Ser Glu Lys Ile Leu Lys Arg Val Lys Gln Tyr Thr Leu Glu His Ile 
                485                 490                 495     


Met Tyr Leu Gly Lys Leu Val His Asn Asn Ile Asp Met Thr Thr Val 
            500                 505                 510         


Asn Thr Asn Asp Phe Ser Lys Phe His Ala Lys Glu Glu Leu Asp Leu 
        515                 520                 525             


Glu Leu Ile Thr Phe Phe Ala Ser Thr Asn Met Glu Leu Asn Lys Ile 
    530                 535                 540                 


Phe Ser Arg Glu Asn Ile Asn Asn Asp Glu Asn Ile Asp Phe Phe Gly 
545                 550                 555                 560 


Gly Asp Arg Glu Lys Asn Tyr Val Leu Asp Lys Lys Asn Leu Asn Ser 
                565                 570                 575     


Lys Ile Lys Ile Ile Arg Asp Leu Asp Phe Ile Asp Asn Lys Asn Asn 
            580                 585                 590         


Ile Thr Asn Asp Phe Ile Asn Lys Phe Thr Lys Ile Gly Thr Asn Glu 
        595                 600                 605             


Arg Asn Arg Ile Leu His Ala Ser Gly Lys Lys Arg Asp Ser Gln Gly 
    610                 615                 620                 


Thr Gln Asp Asp Tyr Asn Lys Val Ile Asn Ile Ile Gln Asn Leu Lys 
625                 630                 635                 640 


Ile Ser Asp Glu Glu Val Ser Lys Val Leu Asn Leu Asp Val Val Phe 
                645                 650                 655     


Lys Asp Lys Lys Asn Ile Ile Thr Glu Ile Asn Asp Ile Lys Ile Ser 
            660                 665                 670         


Glu Lys Asn Ser Asn Asp Ile Lys Tyr Leu Pro Ser Phe Ser Lys Val 
        675                 680                 685             


Leu Pro Glu Ile Leu Asn Leu Tyr Arg Asn Asn Pro Lys Asn Glu Pro 
    690                 695                 700                 


Phe Asp Thr Ile Glu Thr Glu Lys Ile Val Leu Asn Ala Leu Ile Tyr 
705                 710                 715                 720 


Val Asn Lys Glu Leu Tyr Lys Lys Leu Ile Leu Glu Asp Asp Leu Gln 
                725                 730                 735     


Glu Asn Arg Ser Lys Asn Ile Phe Leu Gln Glu Leu Lys Lys Thr Leu 
            740                 745                 750         


Gly Asn Ile Asp Glu Thr Asp Glu Asn Ile Ile Glu Asn Tyr Tyr Lys 
        755                 760                 765             


Asn Ala Gln Ile Ser Ala Ser Lys Gly Asn Asn Lys Ala Ile Lys Lys 
    770                 775                 780                 


Tyr Gln Lys Lys Val Ile Glu Tyr Tyr Ile Gly Tyr Leu Arg Lys Asn 
785                 790                 795                 800 


Tyr Glu Glu Leu Phe Asp Phe Ser Asp Phe Lys Met Asn Ile Gln Glu 
                805                 810                 815     


Ile Lys Lys Gln Ile Lys Asp Ile Asn Asp Asn Lys Thr Tyr Glu Arg 
            820                 825                 830         


Ile Thr Ile Lys Thr Ser Asp Lys Ser Ile Val Ile Asn Asp Asp Phe 
        835                 840                 845             


Glu Tyr Ile Ile Ser Ile Phe Ala Leu Leu Asn Ser Asn Thr Val Ile 
    850                 855                 860                 


Asn Lys Ile Arg Asn Arg Phe Phe Ala Thr Ser Val Trp Leu Asp Thr 
865                 870                 875                 880 


Ser Glu Tyr Gln Asn Ile Ile Asn Ile Leu Asp Glu Ile Met Gln Leu 
                885                 890                 895     


Asn Thr Leu Arg Asn Glu Cys Ile Thr Glu Asn Trp Asn Leu Asn Leu 
            900                 905                 910         


Glu Glu Phe Ile Gln Lys Met Lys Glu Ile Glu Lys Asp Phe Asp Asp 
        915                 920                 925             


Phe Lys Ile Gln Thr Lys Lys Asp Ile Phe Asn Gly Asn Tyr Glu Ser 
    930                 935                 940                 


Ile Lys Asn Asn Val Leu Ser Lys Phe Ile Gly Phe Ser Asp Val Gln 
945                 950                 955                 960 


Lys Ile Leu Glu Glu Lys Leu Asn Asn Leu Ile Asp Phe Glu Asn Asp 
                965                 970                 975     


Asn Glu Ile Lys Lys Ser Leu Asn Leu Asp Ser Leu Asn Pro Asp Glu 
            980                 985                 990         


Arg Arg Asn Leu Met Pro Asn Ile  Asn Pro Lys Lys Gly  Gly Ile Asp 
        995                 1000                 1005             


Leu Ile  Lys Glu Ile Asp Lys  Leu Ile Val Ile Lys  Lys Asn Asn 
    1010                 1015                 1020             


Ile Glu  Lys Asn Ile Leu Leu  Lys Ile Ile Phe Asn  Ser Asp Phe 
    1025                 1030                 1035             


Leu Glu  Lys Tyr Lys Lys Glu  Ile Asp Asn Leu Leu  Glu Asp Thr 
    1040                 1045                 1050             


Glu Thr  Glu Asn Lys Asn Lys  Phe Glu Lys Ile Tyr  Tyr Pro Glu 
    1055                 1060                 1065             


Glu His  Lys Asn Glu Leu Tyr  Ile Tyr Lys Lys Asn  Leu Phe Leu 
    1070                 1075                 1080             


Asn Ile  Gly Asn Pro Asn Phe  Asp Lys Ile Tyr Gly  Leu Ile Ser 
    1085                 1090                 1095             


Asn Asp  Ile Lys Met Ala Asp  Ala Lys Phe Leu Phe  Asp Ser Asp 
    1100                 1105                 1110             


Ser Lys  Asp Ile Arg Asn Asn  Glu Ile Ser Lys Ile  Asp Gly Ile 
    1115                 1120                 1125             


Leu Lys  Asn Leu Asn Asp Lys  Leu Asn Gly Tyr Ser  Lys Glu Tyr 
    1130                 1135                 1140             


Lys Glu  Lys Tyr Val Lys Lys  Leu Lys Glu Ser Asn  Asp Phe Phe 
    1145                 1150                 1155             


Ala Lys  Asn Ile Gln Asn Glu  Asn Tyr Ser Ser Phe  Glu Glu Phe 
    1160                 1165                 1170             


Glu Lys  Asn Tyr Asn Lys Ile  Ser Glu Tyr Lys Lys  Ile Arg Asp 
    1175                 1180                 1185             


Leu Val  Glu Phe Asn Tyr Leu  Asn Lys Ile Glu Ser  Tyr Leu Ile 
    1190                 1195                 1200             


Asp Ile  Asn Trp Lys Leu Ala  Ile Gln Met Ala Arg  Phe Glu Arg 
    1205                 1210                 1215             


Asp Met  His Tyr Ile Val Asn  Gly Leu Asp Tyr Leu  Tyr Ile Ile 
    1220                 1225                 1230             


Arg Leu  Glu Lys Asp Arg Asn  Gln Asp Arg Ser Ser  Pro Tyr Pro 
    1235                 1240                 1245             


Lys Tyr  Lys Asn Gly Val Leu  Asp Tyr Thr Lys Ser  Tyr Tyr Asn 
    1250                 1255                 1260             


Phe Lys  Asp Tyr Gln Glu Phe  Met Asp Ile Cys Ser  Lys Phe Gly 
    1265                 1270                 1275             


Ile Asp  Leu Ser Glu Asn Ser  Glu Ile Asn Lys Pro  Glu Ser Glu 
    1280                 1285                 1290             


Ser Ile  Arg Asn Tyr Ile Ser  His Phe Tyr Ile Val  Arg Asn Pro 
    1295                 1300                 1305             


Phe Val  Asp Tyr Ser Ile Ala  Glu Gln Ile Asp Arg  Val Ser Asn 
    1310                 1315                 1320             


Leu Leu  Ser Tyr Ser Thr Arg  Tyr Asn Asn Ser Thr  Tyr Ala Ser 
    1325                 1330                 1335             


Val Phe  Glu Val Phe Lys Lys  Asp Val Asn Leu Asp  Tyr Asp Glu 
    1340                 1345                 1350             


Leu Lys  Lys Lys Phe Lys Leu  Ile Gly Asn Asn Asp  Ile Leu Glu 
    1355                 1360                 1365             


Lys Leu  Met Lys Ser Lys Lys  Val Ser Val Leu Glu  Leu Glu Ser 
    1370                 1375                 1380             


Tyr Asn  Ser Asp Tyr Val Lys  Asn Leu Ile Ile Lys  Leu Leu Thr 
    1385                 1390                 1395             


Lys Ile  Glu Lys Thr Asn Asp  Thr Leu 
    1400                 1405         


<210>  548
<211>  1373
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  548

Met Ala Lys His Leu Arg Pro Ile Gly Glu Ser Tyr Thr Asp Phe Leu 
1               5                   10                  15      


Asp Glu Thr Glu Phe Val Arg Leu Gly Arg Gly Leu His Arg Gly His 
            20                  25                  30          


His Gly Val Gln Ile Pro Pro Thr Glu Leu Pro Ser Tyr Leu Ala Glu 
        35                  40                  45              


Tyr Arg Lys Ala Leu Met Arg Gln Val Val Ala Val Leu Asp Lys Val 
    50                  55                  60                  


Val Gly Lys Arg Arg Arg Leu Ser Gly Met His Pro Glu Ala Tyr Arg 
65                  70                  75                  80  


Asp Arg Val His Leu Ala Glu Ala Leu Trp Val Arg Leu Val Ala Arg 
                85                  90                  95      


Val Lys Glu Ile Gly Thr Pro Pro Asp Pro Ser Glu Leu Leu Asp Leu 
            100                 105                 110         


Arg Arg Met Trp Asn Ala Lys Ala His Pro Tyr Ala Glu Tyr Asp Val 
        115                 120                 125             


Val Pro Arg Ala Pro Leu Asn Asp Gly Asn Gly Gln Lys Ile Leu Glu 
    130                 135                 140                 


Cys Arg Glu Val Asp Asp Pro Lys Ile Glu Arg Ser Asp Phe Glu Gly 
145                 150                 155                 160 


Arg Trp His Gly Arg Phe Trp Gln Ser Glu Pro Gly Pro Val Asp Tyr 
                165                 170                 175     


Asn Ala Ile Ala Asp Arg Ile Phe Ala His Leu Phe Asp Gln Glu Ala 
            180                 185                 190         


Val Ile Gly Gly Gly Pro Arg Arg Glu Gly Asn Val Thr Val Pro Asp 
        195                 200                 205             


Glu Asp Ile Asn Gly Gln Pro Gly Pro Ala Thr Gly Lys Gly Leu Ile 
    210                 215                 220                 


Ile Ala Arg Gly Gln Ser Ile Val Lys Ser Ala Ser Asp Pro Arg Arg 
225                 230                 235                 240 


Ser Ser Lys Lys Val Gln Arg Thr Trp Asp Lys Ala Val Glu Arg Arg 
                245                 250                 255     


Tyr Phe Gly Asp Asp Gly Lys Gly Gly Ser Asp Ile Ala Lys Ala Ile 
            260                 265                 270         


Tyr Glu Glu Leu Gly Asp Pro Ala Thr Leu Ala Asp Pro Ile Tyr Ala 
        275                 280                 285             


Ser Trp Phe Gly Ser Arg Leu Tyr Asp His Phe Gly Ser Phe Lys Asn 
    290                 295                 300                 


Ser Leu Pro Leu Glu Leu Lys Asp Pro Phe Lys Glu Gln Ile Trp Ala 
305                 310                 315                 320 


Leu His Asn Ser Val Arg Gln Phe Tyr Gln Arg Met Ala Lys Ser Asp 
                325                 330                 335     


Arg Phe Arg Leu Ala Leu Gln Asn Ala Arg Ser Glu Val Pro Asp Arg 
            340                 345                 350         


Ser Glu Leu Leu Ala Leu Leu Pro Lys Asp His Asp His Leu Leu Leu 
        355                 360                 365             


Val Leu Gly Gly Lys Lys Lys Asn Ala Glu Met Ser Glu Leu Ile Arg 
    370                 375                 380                 


Leu Gly Lys Leu Phe Val His Ala Ser Asp Val Leu His Asp Phe Asp 
385                 390                 395                 400 


Ala Asn Asp Ala Ala Ala Leu Asp Ala Phe Lys Arg Arg Met Ser Phe 
                405                 410                 415     


Leu Ala Thr Ser Ile Gly Gln Ser Glu Ile Lys Gln Thr Glu Thr Phe 
            420                 425                 430         


Ala Arg Thr Trp Arg Gly Ala Val Gly Leu Thr Leu Arg Thr Val Lys 
        435                 440                 445             


Gly Leu Ala Asp Pro Arg Gly Ile Ile Gly Thr Pro Asp Asn Arg Asp 
    450                 455                 460                 


Leu Gly Thr Ala Gly Pro Met Lys Asp Ala Phe Asn Lys Phe Asp Gln 
465                 470                 475                 480 


Pro His Phe Gln Gln His Met Thr Ile Ile Phe Gly Asn Lys Glu Leu 
                485                 490                 495     


Gln Ala Glu Gly Asn Pro Thr Arg Ser Ser Val Phe Thr Ala Asn Gly 
            500                 505                 510         


Asp Lys Asp His Gln Ala Glu Leu Leu Trp Gly Phe Leu Cys Val Val 
        515                 520                 525             


Arg Ser Val Arg Asn Arg Thr Asn His Tyr Asn Val Arg Arg Ala Leu 
    530                 535                 540                 


Leu Arg Leu Leu Asp Glu Gly Ile Val Ser Pro Met Pro Ser Asp Pro 
545                 550                 555                 560 


Lys Lys Glu Arg Val Glu Asn Arg Asn Leu Cys Thr Val Ser Pro Thr 
                565                 570                 575     


Ala Leu Glu Ala Phe Arg Arg Leu Leu Asn Phe Asp Leu Ala Ile Gln 
            580                 585                 590         


Lys Glu Ala Val Arg Thr Ala Leu Glu Gln Ala Lys Ala Ser Glu Phe 
        595                 600                 605             


Val Glu Glu Gly Lys Leu Arg Gly Leu Val Ser Glu Leu Ala Gly Thr 
    610                 615                 620                 


Glu Asp Met Pro Ala Leu His Ile Pro Arg Phe Ser Ala Val Met Asp 
625                 630                 635                 640 


Lys Val Arg Arg Leu Ala Asp Asn Arg Asp Val Gly Leu Asp Pro Ile 
                645                 650                 655     


Leu Ser Thr Leu Gln Arg Ser Leu Pro Pro Thr Asp Lys Gln Ala Glu 
            660                 665                 670         


Ser Asp Ala Ala Arg Cys Arg Tyr Arg Leu Leu Leu Glu Leu Tyr Lys 
        675                 680                 685             


Ser Gly Phe Arg Ser Trp Phe Ser Gly Ile Gln Ser Asn Glu Glu Asn 
    690                 695                 700                 


Asn Arg Glu Ile Cys His Trp Ala Val Lys Gln Val Gly Arg Ala Lys 
705                 710                 715                 720 


Asp Ala Arg Lys Ser Glu Tyr Asp Lys Lys Thr Lys Arg His Tyr Arg 
                725                 730                 735     


Ser Pro Asn Ser Leu Ile Asp Asp Leu Gly Leu Asp Lys Phe Asp Asp 
            740                 745                 750         


Leu Thr Asp Leu Leu Glu Ala Leu Ala Ser Gln Ser Thr Arg Glu His 
        755                 760                 765             


Asp Gln Asn Leu Lys Tyr Val Pro Asp Ala Arg Val Gln Ser Gln Met 
    770                 775                 780                 


Ser Asn Arg Ile Glu Glu Phe Arg Gln Glu Leu Phe Ala His Ile Phe 
785                 790                 795                 800 


Thr Lys Tyr Leu Asp Thr His Asp Phe Gly Trp Ile Gly Ala Ile Glu 
                805                 810                 815     


Val Arg Arg Glu Ala Cys Asp Leu Ala Asp Val Val Ser Ala Phe Glu 
            820                 825                 830         


Val Arg Asp Gln Lys Phe Asp Ala Asp Trp His Ser Gln Phe Tyr Ala 
        835                 840                 845             


Trp Leu Tyr Met Val Pro Pro Ile Glu Ala Ser Arg Leu Arg His Gln 
    850                 855                 860                 


Met Arg Lys Ser Ala Val Met Asp Asp Lys Trp Ser Thr Thr Leu Glu 
865                 870                 875                 880 


Leu Thr Ser Gly Asp Arg Lys Thr Arg Asp Asp His Ala Gln Asp Val 
                885                 890                 895     


Leu Ala Asp Met Asp Arg Leu Phe Ser Leu Tyr Thr Lys Val Gln Ala 
            900                 905                 910         


Ala Gly Phe Asn Gly Gln Glu His Glu Ser Ala Leu Gly Ser Lys Ser 
        915                 920                 925             


Leu Phe Tyr Glu Asp Gly Asn Gln Phe Asp Glu Val Tyr Ser Pro Asp 
    930                 935                 940                 


Thr Glu Thr His Asn Lys Thr Phe Pro Gly Thr Arg Arg Gly Leu Arg 
945                 950                 955                 960 


Gln Leu Val Arg Tyr Ala His Leu Pro Ala Leu Glu Gly Val Phe Lys 
                965                 970                 975     


Lys His Arg Ile Thr Lys Ala Glu Val Glu Thr Phe Val Ala Leu Tyr 
            980                 985                 990         


Asp Glu Asn Arg Arg Asp Pro Gly  Ser Val Ala His Met  Leu Arg Arg 
        995                 1000                 1005             


Glu Lys  Leu Arg Thr Glu Ile  Leu Arg Ser Ile His  Asp Gly Pro 
    1010                 1015                 1020             


Lys Pro  Lys Asp Lys Asp Phe  Trp Pro Lys Leu Glu  Ala Lys Cys 
    1025                 1030                 1035             


Leu Glu  Tyr Arg Thr Val Ala  Thr Glu Thr Ala Ile  Tyr Asn Phe 
    1040                 1045                 1050             


Gln Ala  Asn Ala Ala Arg Leu  Asn Asp His Ala Arg  Leu His Gln 
    1055                 1060                 1065             


Ile Val  Met Arg Val Val Ala  Arg Leu Thr Asp Tyr  Ala Leu Ile 
    1070                 1075                 1080             


Trp Glu  Arg Asp Arg Leu Phe  Ala Phe Val Gly Met  Leu Tyr Arg 
    1085                 1090                 1095             


Gln Thr  Gly Gly Thr Gly Ile  Asn Pro Ala Met Arg  His Ala Glu 
    1100                 1105                 1110             


Lys Thr  Asn Ala Pro Pro Arg  Ile Gly Ile Leu Val  Ser Asp Ser 
    1115                 1120                 1125             


Ala Leu  Ala Lys Lys Leu Asn  Ser Asn Ser Ala Glu  Val Phe Ile 
    1130                 1135                 1140             


Pro Tyr  Leu Asp Thr Glu Thr  Gly Phe Asp Ala Pro  Arg Phe Asp 
    1145                 1150                 1155             


Asp Leu  Cys Thr Leu Leu Ser  His Glu His Ala Lys  Glu Phe Arg 
    1160                 1165                 1170             


Phe His  Phe Leu Glu Val Gly  Glu Glu Asn Ser Lys  Asp Glu Ala 
    1175                 1180                 1185             


Arg Arg  Leu Asn Glu Glu Thr  Met Gly His Arg Lys  Arg Pro Ala 
    1190                 1195                 1200             


Phe Lys  Arg Gly Thr Arg Arg  Gln Gly Ile Arg Asn  Asp Leu Ala 
    1205                 1210                 1215             


His His  Asn Val Leu Asp Leu  Ala Gly Gly Ala Gly  Pro Asn Leu 
    1220                 1225                 1230             


Thr Tyr  Val Val Asn Ala Val  Arg Ser Leu Leu Ser  Tyr Asp Arg 
    1235                 1240                 1245             


Lys Leu  Lys Asn Ala Val Pro  Lys Ser Ile Lys Arg  Ile Leu Gly 
    1250                 1255                 1260             


Glu Glu  Gly Leu Ile Ile Glu  Trp Gln Met Asn Tyr  Asp Arg Leu 
    1265                 1270                 1275             


Lys Lys  Pro Thr Val Tyr Pro  Asn Val Glu Thr His  Leu Thr Met 
    1280                 1285                 1290             


Val Pro  Pro Arg His Met Thr  Ala Pro Val Ser Phe  Thr Leu Pro 
    1295                 1300                 1305             


Arg Ala  Ser Val Arg Leu Ala  Ser Met Val Lys Ala  Val Phe Asp 
    1310                 1315                 1320             


Phe Gly  Ser Ser Gly Tyr Gly  Glu Glu Arg Met Ile  Gly Gly Arg 
    1325                 1330                 1335             


Thr Ala  Lys Gln Ala Val Tyr  Pro Asp Asp Phe Thr  Arg Arg Phe 
    1340                 1345                 1350             


Pro Gln  Thr Pro Met Gly Leu  Lys Gln Ala Thr Arg  Leu Val Phe 
    1355                 1360                 1365             


Ala Ser  Glu Asn Ser 
    1370             


<210>  549
<211>  1287
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  549

Met Arg Ile Gly Lys Val Gln Gly Arg Thr Phe Thr Gly Phe Asp Asn 
1               5                   10                  15      


Ala Arg Gly Lys Thr Leu Arg Arg Arg Leu Leu Thr Arg Pro Asp Asn 
            20                  25                  30          


Glu Ala Arg Ser Leu Ser Glu His Leu Ala His Asp Pro Lys Ala Leu 
        35                  40                  45              


Ile Gly Gln Ala Ile Ser Arg Ile Asp Thr Ile Tyr Gln Lys Pro Lys 
    50                  55                  60                  


Thr Gly Lys Pro Thr Pro Glu Gln Phe Gly His Arg Asp Thr Leu Gly 
65                  70                  75                  80  


Trp Ala Tyr Trp Lys Leu Leu Val Ala Ser Tyr Pro Glu Val Glu Gly 
                85                  90                  95      


His Arg Asp Leu Phe Val Arg Arg Leu His Pro Tyr Gly Asp Thr Pro 
            100                 105                 110         


Pro Lys Ser His Gly Gln Lys Glu Gly Glu His Gln Lys Gly Gly Lys 
        115                 120                 125             


Pro Gln Leu Glu Gly Arg Trp His Gly Val Met Ala Gln His Gly Lys 
    130                 135                 140                 


Asn Pro Asp Gln Ile Ala Ala Arg Leu Phe Asp His Leu His Asn Ser 
145                 150                 155                 160 


Glu Leu Arg Phe Gly Gly Thr Ala Ser Gly Glu Pro Arg Thr Arg Pro 
                165                 170                 175     


Gly Lys Glu Ala Thr Pro Thr Gly Leu Ile Gly Ala Arg Ala Lys Thr 
            180                 185                 190         


Ile Glu His Ser Val Leu Pro Arg Asp Ala Lys Arg Phe Val Ala Glu 
        195                 200                 205             


Trp Arg Gly Glu Asp Gln Glu Arg Tyr Ala Gly Ala Arg Asp Ile Ala 
    210                 215                 220                 


Ala Ala Ile Ser Ala Gly Leu Asn Asp Lys Asp Gln Lys Ser Gly Ser 
225                 230                 235                 240 


Gly Arg Lys Ser Ala Val Ile Gly Lys Leu Leu Ser Asp His Leu Glu 
                245                 250                 255     


Thr Leu Thr Gly Asn Arg Lys Cys Arg Phe Asp Pro Lys Ser Thr Ala 
            260                 265                 270         


Glu Thr Leu Glu Leu Arg Asp Gly Glu Ser Val Asp Asp Arg Arg Arg 
        275                 280                 285             


Ile Leu Glu Leu His Ala Glu Val Lys Ala Thr Tyr Lys Arg Met Ala 
    290                 295                 300                 


Ala Trp Lys Pro Ala Lys Leu Pro Arg Asn Ser Asp Glu Leu Phe Arg 
305                 310                 315                 320 


Leu Val Arg Gln Gln Ala Asp Asn Arg Ile Leu Asn His Leu Val Arg 
                325                 330                 335     


Val Gly Arg Ile Ser Val Tyr Ser Glu Gln Ser Asp Ala Leu Ser Glu 
            340                 345                 350         


Ser Gln Phe Trp Thr Ser Gly Gly Gln Thr Gln Ile Lys Glu Ser Glu 
        355                 360                 365             


Val Phe Ala Arg Leu Trp Ile Gly Ala Ile Ser Arg Ala Ser Tyr Ser 
    370                 375                 380                 


Met Lys Ala Trp Leu Glu Pro Glu Gly Thr Val Phe Asn Pro Ser Ile 
385                 390                 395                 400 


Asn Asp Phe Asp Val Thr Ser Ser His Asn Thr Asn Arg Ile Leu Glu 
                405                 410                 415     


Asp Ser Gly Arg Leu Ser Asn Ala Met Ala Arg Arg Ala Ile Tyr Phe 
            420                 425                 430         


Gly Glu Thr Pro Glu Phe Asp Ala Leu Gly Glu Glu Asp Gln Arg Val 
        435                 440                 445             


Leu Val Lys Lys Cys Leu Asp Ala Leu Ser Ala Cys Arg Asn Arg Thr 
    450                 455                 460                 


Phe His His Gly Gln Arg Ala Lys Phe Leu Lys Glu Val Arg Lys Gly 
465                 470                 475                 480 


Leu Lys Glu Lys Glu Ala Asp Ser Ala Gly Pro Ala Ala Trp Glu Gly 
                485                 490                 495     


Ile Arg Glu Val Ile Gln Ala Asp Ala Arg Asn Leu Gly Ala Arg Leu 
            500                 505                 510         


Leu Gln Asp Leu Thr Gly Ala Lys Val His Ser Phe Ala Thr Asp Pro 
        515                 520                 525             


Glu Phe Arg His Leu Tyr Glu Ser Val Ala Ala Thr Leu Thr Ala Gly 
    530                 535                 540                 


Gly Glu Leu Glu Ala Ala Leu Pro Arg Leu Lys Asn Val Leu Lys Arg 
545                 550                 555                 560 


Ala Glu Gly Val Arg Cys Tyr Leu Asp Thr Pro Ser Gln Arg Arg Glu 
                565                 570                 575     


Gly Asp Glu Ser Leu Ile Ala Arg Leu Pro Val Ala Pro Val Pro Arg 
            580                 585                 590         


Glu Leu Asp Asp Ala Ala Thr Lys Ala Arg His Ser Ala Leu Leu Arg 
        595                 600                 605             


Leu Tyr Asp Gly Pro Phe Arg Pro Trp Ala Thr Glu Leu Arg Gly Glu 
    610                 615                 620                 


Arg Leu Ser Asp Tyr Ala Ala Arg Ala Lys Arg Leu Ala Thr Arg Leu 
625                 630                 635                 640 


Ala Lys Ser Thr Asn Thr Ala Ser Pro Tyr Pro Asp Ser Val Glu Gly 
                645                 650                 655     


Arg Ser Val Arg Leu Arg Asp Pro Ile Thr Ala Asp Thr Ala Pro Glu 
            660                 665                 670         


Thr Leu Lys Thr Tyr Leu Ser Ala Leu Thr Ala Glu Thr Ala Thr Glu 
        675                 680                 685             


Phe Arg Val Gln Lys Gly Tyr Glu Ser Asp Gly Glu Lys Ala Lys Glu 
    690                 695                 700                 


Gln Ala Glu Phe Ile Glu Asp Phe Arg Arg Asp Met Ile Ala Leu Ala 
705                 710                 715                 720 


Phe Gln Asp Phe Ile Arg Asp His Gly Phe Ala Trp Leu Leu Asp Ile 
                725                 730                 735     


Ala Ser Lys Ala Glu Pro Ser Asn Asp Ala Pro Asn Leu Pro Asp Pro 
            740                 745                 750         


Val Asp Thr Gly Lys Asp Thr Val Phe Glu Asp Trp Gln Ala Leu Leu 
        755                 760                 765             


Tyr Leu Phe Leu His Phe Val Pro Ala Asp Asp Val Ser Gln Leu Leu 
    770                 775                 780                 


His Gln Leu Arg Lys Trp Asp Ala Leu Gln Asp Lys Tyr Glu Leu Ala 
785                 790                 795                 800 


Glu Pro Gly Glu Thr Leu Gly Gln Thr Lys Ala Asp Thr Arg Lys Ile 
                805                 810                 815     


Val Gly Gln Phe Arg Asp Cys Leu Thr Leu Phe Leu Lys Thr Gly Asp 
            820                 825                 830         


Ala Arg Phe Asp Gly Glu Gly Val Glu Leu Pro Leu Ser Asp Phe Gln 
        835                 840                 845             


Glu Leu Phe Glu Ser Pro Ala Thr Phe Lys Glu Leu Phe Leu Ala Glu 
    850                 855                 860                 


Pro Ala Glu Asn Asp Ala Ser Glu Thr Asp Asp Gln Asp Ala Pro Gly 
865                 870                 875                 880 


Glu Lys His Arg Val Thr Arg Thr Arg Arg Gly Leu Arg Gln Ile Leu 
                885                 890                 895     


Arg Tyr Asn His Met Pro Val Leu Arg Asp Leu Phe Leu Ala His Lys 
            900                 905                 910         


Val Thr Asp Ala Glu Val Asp Gly Leu Gln Ala Leu Glu Val Asp Asp 
        915                 920                 925             


Pro Gln Thr Gly Glu Ser Gln Ile Gly Ala Ala Gln Arg Ile Arg Thr 
    930                 935                 940                 


Glu Ile His His His Thr Ser Asn Asp Lys Gln Ile Ser Glu Ala Lys 
945                 950                 955                 960 


Val Glu Glu Tyr Arg Arg Ala Leu Ser Thr Ile Glu Arg His Arg Phe 
                965                 970                 975     


Leu Val Gly Arg Val Tyr Leu Gly Asp His Ile Arg Val His Lys Leu 
            980                 985                 990         


Met Met Asp Val Met Gly Arg Leu  Val Asp Phe Ala Gly  Ala Trp Glu 
        995                 1000                 1005             


Arg Glu  Ala Ala Asp Gly Asp  Arg Lys Gly Phe Ile  Ser Arg Ala 
    1010                 1015                 1020             


Ile Ala  Leu Pro Glu Val Ala  Glu Gly Tyr Ala Ala  Asp Arg Leu 
    1025                 1030                 1035             


Lys Thr  Val Ala Arg Arg Val  Leu Asp Asp Gly Glu  Ala Arg Arg 
    1040                 1045                 1050             


Ile Arg  Asn Asp Leu Gly His  Phe Asn Asp Leu Ala  Pro Thr Ser 
    1055                 1060                 1065             


Gly Pro  Ala Asn Leu Thr Phe  Val Val Asn Arg Ala  Arg Arg Met 
    1070                 1075                 1080             


Met Arg  His Asp Arg Lys Arg  Lys Asn Ala Val Thr  Lys Ser Val 
    1085                 1090                 1095             


Ile Glu  Ile Leu Asn Arg Gln  Gly Leu Gly Ile Glu  Trp Thr Met 
    1100                 1105                 1110             


Arg Asn  His Glu Leu Cys Glu  Ala Lys Leu Trp Gln  Asn Pro Val 
    1115                 1120                 1125             


Lys His  Leu Gly Phe Ala Thr  Leu Glu Gly Arg Gly  Lys Lys Trp 
    1130                 1135                 1140             


Arg Arg  Pro Phe Glu Ala Arg  Tyr Gly Asp Ala Tyr  Met Ala Met 
    1145                 1150                 1155             


Val Ala  Gln Leu Phe Asp Gly  Thr Val Thr Ser Pro  Pro Ala Lys 
    1160                 1165                 1170             


Gly Pro  Pro Gln Ser Gly Lys  Ser Gly Gly Lys Pro  Gly Lys Gly 
    1175                 1180                 1185             


Ala Glu  Gly Gly Ala Lys Glu  Lys Ser Arg Ser Pro  Thr Arg Met 
    1190                 1195                 1200             


Glu Glu  Gly Gly Val Tyr Glu  Gly Arg Val Ala Lys  Ala Lys Ser 
    1205                 1210                 1215             


Asp Lys  Gly Phe Gly Phe Leu  Leu Val Glu Gly Ala  Gln Glu Glu 
    1220                 1225                 1230             


Ile Phe  Leu His Ile Tyr Gly  Ile Ser Gly Asn Arg  Pro Ala Arg 
    1235                 1240                 1245             


Ile Glu  Asn Gly Gln Arg Tyr  Arg Phe Thr Leu Gly  Ile Asp Arg 
    1250                 1255                 1260             


Asp Arg  Glu Arg Arg Lys Glu  Arg Ala Trp Val Ala  Arg Glu Ala 
    1265                 1270                 1275             


Val Arg  Ile Asp Glu Asn Arg  Ser Lys 
    1280                 1285         


<210>  550
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  550

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asn Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Val Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Val 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Lys Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Val Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Lys Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Met 
    690                 695                 700                 


Tyr Ile Gly Asn Asp Glu Gln Ile Asn Thr Ser Leu Ala Gly Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Lys Ile Leu Lys Tyr Thr Glu Ser Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Lys Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Leu Lys Glu Leu Lys Glu Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn Tyr Thr Met Gln Gln Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Lys Lys Asp Glu Lys Phe Asn Asp Glu Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Lys Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Glu Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Glu  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  551
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  551

Met Gly Asn Leu Phe Gly His Lys Lys Trp Tyr Lys Ala Asp Lys Ile 
1               5                   10                  15      


Ile Lys Asp Lys Lys Gly Lys Glu Ser Thr Ile Lys Gln Glu Val Arg 
            20                  25                  30          


Ile Lys Arg Asn Tyr Ser Val Asp Arg Tyr Thr Leu Asn Thr Asn Asn 
        35                  40                  45              


Lys Glu Lys Asn Asn Ile Asn Asn Glu Asp Phe Val Asn Gln Phe Ile 
    50                  55                  60                  


Glu Tyr Lys Thr Asn Asn Asp Ile Phe Lys Lys Phe Thr Arg Lys Phe 
65                  70                  75                  80  


His Met Gly Asn Ile Leu Phe Lys Leu Lys Gly Asn Lys Arg Ser Ile 
                85                  90                  95      


Glu Asp Ser Asn Asp Phe Leu Lys Thr Glu Glu Ile Ile Leu Asp Lys 
            100                 105                 110         


Glu Val Tyr Gly Gln Ser Glu Lys Leu Arg Asn Glu Lys Gly Ile Thr 
        115                 120                 125             


Lys Gln Gly Ile Leu Lys Glu Ile Asn Tyr Arg Gly Ile Asn Glu Ser 
    130                 135                 140                 


Asn Asp Ser Ile Leu Ile Lys Thr Lys Phe Gly Lys Glu Ile Lys Ile 
145                 150                 155                 160 


Asn Phe Thr Asp Glu Ala Lys Lys Asn Lys Asn Glu Tyr Gln Ile Thr 
                165                 170                 175     


Leu Lys Ile Ile Pro Glu Asn Glu Leu Lys Ile Lys Arg Glu Val Tyr 
            180                 185                 190         


Asp Val Phe Lys Met Ile Asn Met Asp Leu Tyr Gln Ile Ile Lys Glu 
        195                 200                 205             


Ile Ile Glu Asn Glu Val Gln Lys Val Phe Lys Asn Arg Tyr Tyr Glu 
    210                 215                 220                 


Glu Tyr Leu Arg Glu Lys Leu Leu Lys Asp Asp Lys Thr Gly Val Ile 
225                 230                 235                 240 


Leu Thr Asn Phe Ile Glu Ile Arg Glu Lys Ile Lys Ser Asn Leu Glu 
                245                 250                 255     


Ile Met Gly Phe Val Lys Phe Tyr Leu Asn Val Gly Gly Asp Lys Lys 
            260                 265                 270         


Lys Ser Glu Asn Lys Lys Ile Phe Val Glu Lys Ile Leu Asn Ile Asn 
        275                 280                 285             


Val Asp Leu Thr Val Glu Asp Ile Val Asp Phe Ile Val Lys Glu Leu 
    290                 295                 300                 


Lys Phe Trp Asn Ile Thr Lys Arg Ile Glu Lys Leu Gln Glu Lys Thr 
305                 310                 315                 320 


Val Asn Arg Ala Asp Glu Asp Ile Glu Asn Thr Tyr Ile Asn Thr Tyr 
                325                 330                 335     


Val Leu Leu Asp Lys His Glu Lys Phe Lys Lys Tyr Asn Arg Asn Lys 
            340                 345                 350         


Lys Asp Thr Ile Val Lys Ser Phe Ile Lys Asp Ile Lys Asp Asn Thr 
        355                 360                 365             


Met Lys Gln Lys Ile Asn Gln Ile Leu Arg Lys Phe Lys Ile Asp Glu 
    370                 375                 380                 


Leu Ile Lys Lys Thr Glu Lys Glu Leu Lys Arg Gly Asn Cys Asp Thr 
385                 390                 395                 400 


Glu Ile Phe Gly Ile Phe Lys Val His Tyr Gln Glu Met Phe Ser Ser 
                405                 410                 415     


Glu Lys Phe Glu Lys Lys Ser Asp Glu Glu Lys Glu Leu Tyr Lys Ile 
            420                 425                 430         


Ile Tyr Arg Tyr Leu Lys Gly Arg Ile Glu Lys Ile Leu Val Asn Glu 
        435                 440                 445             


Gln Lys Val Arg Leu Lys Lys Ile Glu Lys Ile Leu Asn Glu Ser Ile 
    450                 455                 460                 


Leu Ser Glu Lys Ile Leu Lys Arg Val Lys Gln Tyr Thr Leu Glu Tyr 
465                 470                 475                 480 


Ile Met Tyr Leu Gly Lys Leu Val His Asn Lys Ile Asn Met Ala Thr 
                485                 490                 495     


Val Asn Thr Asn Asp Phe Phe Arg Leu His Ala Lys Glu Glu Leu Asp 
            500                 505                 510         


Leu Glu Leu Ile Thr Phe Phe Ala Ser Thr Asn Met Glu Leu Asn Lys 
        515                 520                 525             


Ile Phe Asn Gly Lys Glu Lys Val Thr Asp Phe Phe Gly Phe Asn Leu 
    530                 535                 540                 


Asn Gly Gln Lys Ile Thr Leu Lys Glu Lys Val Pro Ser Phe Lys Leu 
545                 550                 555                 560 


Asn Ile Leu Lys Lys Leu Asn Phe Ile Asn Asn Glu Asn Asn Ile Asp 
                565                 570                 575     


Glu Lys Leu Ser His Phe Tyr Ser Phe Gln Lys Lys Gly Tyr Leu Leu 
            580                 585                 590         


Arg Asn Lys Ile Leu His Asn Ser Tyr Gly Asn Ile Gln Glu Thr Ile 
        595                 600                 605             


Asn Leu Lys Gly Glu Tyr Glu Asn Val Glu Asn Leu Ile Lys Glu Leu 
    610                 615                 620                 


Lys Val Ser Asn Glu Glu Ile Ser Lys Ser Leu Asn Leu Asp Ile Ile 
625                 630                 635                 640 


Phe Glu Gly Lys Val Asp Ile Ile Asn Lys Ile Asn Ser Leu Glu Ile 
                645                 650                 655     


Gly Glu Tyr Lys Asp Lys Lys Tyr Leu Pro Ser Phe Ser Lys Ile Val 
            660                 665                 670         


Pro Glu Ile Met Arg Lys Phe Arg Glu Ile Asn Lys Asp Lys Ser Phe 
        675                 680                 685             


Asp Ile Glu Ser Glu Lys Ile Ile Leu Asn Ala Val Gln Tyr Val Asn 
    690                 695                 700                 


Lys Ile Leu Tyr Glu Lys Ile Thr Ser Asn Glu Glu Asn Glu Phe Ile 
705                 710                 715                 720 


Lys Thr Leu Pro Asp Lys Leu Val Lys Lys Asn Asn Asn Lys Glu Asn 
                725                 730                 735     


Asn Asn Ser Leu Ser Ile Glu Glu Tyr Tyr Lys Asn Ala Gln Ile Ser 
            740                 745                 750         


Ser Ser Lys Gly Asp Lys Lys Ala Ile Lys Lys Tyr Gln Asn Lys Val 
        755                 760                 765             


Thr Asn Ala Tyr Ile Glu Tyr Leu Glu Asn Thr Phe Ala Glu Val Ile 
    770                 775                 780                 


Asp Phe Ser Asn Phe Asn Leu Asn Phe Asp Glu Ile Lys Thr Lys Ile 
785                 790                 795                 800 


Glu Glu Arg Lys Tyr Ser Lys Ser Lys Ile Thr Val Asp Ser Ile Ser 
                805                 810                 815     


Thr Asn Ile Asn Ile Thr Asn Asp Ile Glu Tyr Ile Ile Ser Ile Phe 
            820                 825                 830         


Ala Leu Leu Asn Ser Asn Thr Tyr Ile Asn Lys Ile Arg Asn Arg Phe 
        835                 840                 845             


Phe Ala Thr Ser Val Trp Leu Asp Lys Gln Asn Ser Thr Lys Glu Tyr 
    850                 855                 860                 


Asp Tyr Glu Asn Ile Ile Asp Ile Leu Asp Lys Ile Leu Ser Ile Asn 
865                 870                 875                 880 


Leu Leu Arg Glu Asn Asn Ile Ala Asp Ile Leu Asp Leu Lys Asn Thr 
                885                 890                 895     


Ile Ile Glu Ala Lys Ile Val Glu Asn Asn Glu Glu Cys Ile Lys Asn 
            900                 905                 910         


Tyr Ile Phe Glu Asn Asn Glu Glu Glu Leu Lys Lys Arg Leu Phe Cys 
        915                 920                 925             


Glu Glu Leu Val Asn Lys Glu Asp Val Leu Lys Ile Phe Glu Asp Lys 
    930                 935                 940                 


Asn Phe Lys Phe Lys Asn Phe Ile Lys Lys Thr Gly Asn Glu Asn Phe 
945                 950                 955                 960 


Thr Ile Asn Phe Asp Ile Leu Phe Asn Leu Glu Cys Asn Ser Glu Leu 
                965                 970                 975     


Asn Val Lys Lys Val Met Gly Gln Asn Ser Gln Arg Leu Asn Leu Phe 
            980                 985                 990         


Ile Lys Asn Thr Ile Asp Glu Tyr  Lys Ser Lys Ile Lys  Thr Ser Phe 
        995                 1000                 1005             


Ser Ser  Glu Phe Leu Glu Lys  Tyr Lys Lys Glu Ile  Asp Asn Leu 
    1010                 1015                 1020             


Val Glu  Asp Thr Glu Ser Glu  Asn Lys Asn Lys Phe  Glu Lys Ile 
    1025                 1030                 1035             


Tyr Tyr  Pro Lys Glu His Lys  Asn Glu Leu Tyr Ile  Tyr Lys Lys 
    1040                 1045                 1050             


Asn Leu  Phe Leu Asn Ile Gly  Asn Pro Asn Phe Asp  Lys Ile Tyr 
    1055                 1060                 1065             


Glu Leu  Ile Ser Lys Asp Ile  Lys Asn Ala Asn Thr  Glu Ile Leu 
    1070                 1075                 1080             


Phe Asp  Asp Asp Ile Arg Lys  Asn Lys Ile Ser Glu  Ile Asp Ala 
    1085                 1090                 1095             


Ile Leu  Lys Asn Leu Asn Asp  Lys Leu Asn Gly Tyr  Ser Asn Asp 
    1100                 1105                 1110             


Tyr Lys  Ala Lys Tyr Val Asn  Lys Leu Lys Glu Asn  Asp Asp Phe 
    1115                 1120                 1125             


Phe Ala  Lys Asn Met Lys Asn  Glu Asn Tyr Ser Ser  Phe Gly Glu 
    1130                 1135                 1140             


Phe Glu  Lys Asp Tyr Asn Lys  Val Ser Glu Tyr Lys  Lys Ile Arg 
    1145                 1150                 1155             


Asp Leu  Val Glu Phe Asn Tyr  Leu Asn Lys Ile Glu  Ser Tyr Leu 
    1160                 1165                 1170             


Ile Asp  Ile Asn Trp Lys Leu  Ala Ile Gln Met Ala  Arg Phe Glu 
    1175                 1180                 1185             


Arg Asp  Met His Tyr Ile Val  Asn Gly Leu Arg Glu  Leu Gly Ile 
    1190                 1195                 1200             


Ile Lys  Leu Ser Gly Tyr Asn  Thr Gly Ile Ser Arg  Ala Tyr Pro 
    1205                 1210                 1215             


Lys Arg  Asn Gly Ser Asp Gly  Phe Tyr Thr Thr Thr  Ala Tyr Tyr 
    1220                 1225                 1230             


Lys Phe  Phe Asp Glu Glu Ser  Tyr Lys Lys Phe Glu  Lys Ile Cys 
    1235                 1240                 1245             


Tyr Gly  Phe Gly Ile Asp Leu  Ser Glu Asn Ser Glu  Ile Asn Lys 
    1250                 1255                 1260             


Pro Glu  Asn Glu Ser Ile Arg  Asn Tyr Ile Ser His  Phe Tyr Ile 
    1265                 1270                 1275             


Val Arg  Asn Pro Phe Val Asp  Tyr Ser Ile Ala Glu  Gln Ile Asp 
    1280                 1285                 1290             


Arg Val  Ser Asn Leu Leu Ser  Tyr Ser Thr Arg Tyr  Asn Asn Ser 
    1295                 1300                 1305             


Thr Tyr  Ala Ser Val Phe Glu  Val Phe Lys Lys Asp  Val Asn Leu 
    1310                 1315                 1320             


Asp Tyr  Asp Lys Leu Lys Thr  Lys Phe Lys Leu Phe  Asp Asp Glu 
    1325                 1330                 1335             


Lys Asn  Asp Asn Ile Lys Ile  Leu Lys Ile Glu Asn  Leu Ile Glu 
    1340                 1345                 1350             


Ser Lys  Lys Val Ser Val Leu  Glu Leu Glu Ser Tyr  Asn Ser Asp 
    1355                 1360                 1365             


Tyr Ile  Lys Asn Leu Ile Ile  Glu Leu Leu Thr Lys  Ile Glu Asn 
    1370                 1375                 1380             


Thr Asn  Asp Thr Leu 
    1385             


<210>  552
<211>  1179
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  552

Met Gly Ser Gly Lys Tyr Arg Ile Thr Lys Ile Ala Arg Lys Trp Asp 
1               5                   10                  15      


Lys Asn Glu Asn Trp Glu Lys Ile Ile Leu Lys Arg Ile Val Asp Asn 
            20                  25                  30          


Lys Lys Ile Lys Tyr Val Asn Glu Asn Asn Asn Lys Asp Val Asp Ile 
        35                  40                  45              


Thr Asp Thr Tyr Tyr Ser Ile Leu Ser Lys Asn Asn Ser Lys Phe Leu 
    50                  55                  60                  


Gly Ser Glu Glu Gln Phe Ile Phe Lys Val Asn Lys Met Lys Arg Asn 
65                  70                  75                  80  


Ile Lys Asn Asp Cys Val Ile Ile Lys Asp Tyr Thr Glu Glu Glu Phe 
                85                  90                  95      


Glu Lys Phe Asp Lys Lys Ile Phe Phe Ser Arg Lys Ile Lys Val Asn 
            100                 105                 110         


Asn Glu Asp Arg Glu Lys Ile Cys Arg Asn Phe Tyr Glu Asp Glu Arg 
        115                 120                 125             


Glu Ile Met Lys Lys Arg Leu Glu Glu Ala Lys Asn Phe Asn Asn Ile 
    130                 135                 140                 


Ile Phe Lys Ile Cys Asn Glu Ile Phe Asn Leu Glu Tyr Ile Asn Tyr 
145                 150                 155                 160 


Thr Asp Glu Lys Ile Tyr Lys Ile Phe Gln Glu Lys Ile Gly Phe Glu 
                165                 170                 175     


Asp Ile Lys Asn Leu Lys Glu Val Phe Lys Gln Gln Lys Lys Gly Leu 
            180                 185                 190         


Glu Thr Asp Lys Leu Leu Ala Ile Ser Phe Asn Lys Asn Arg Asn Asn 
        195                 200                 205             


Val Leu Leu Glu Phe Ile Gln Gln Ile Val Lys Gln Glu Phe Glu Asn 
    210                 215                 220                 


Lys Glu Glu Leu Lys Asn Trp Phe Ser His Glu Gly Glu Lys Tyr Cys 
225                 230                 235                 240 


Lys Glu Ile Phe Lys Ile Tyr Ser Asn Met Ser Gln Lys Glu Lys Tyr 
                245                 250                 255     


Ser Lys Leu Leu Gly His Asn Asp Lys Ser Thr Ala Ser Tyr Ser Glu 
            260                 265                 270         


Lys Arg Glu Thr Leu Gln Arg Arg Leu Lys Leu Gly Asp Tyr Ser Lys 
        275                 280                 285             


Tyr Asp Leu Lys Lys Tyr Tyr Gln Lys Asp Tyr Lys Glu Lys Ala Ile 
    290                 295                 300                 


Lys Glu Leu Lys Asp Lys Asn Lys Glu Glu Phe Glu Arg Glu Ile Glu 
305                 310                 315                 320 


Glu Ile Ile Lys Lys Asn Tyr Lys Ile Asp Lys Leu Cys Asp Glu Ile 
                325                 330                 335     


Ser Asn Leu Glu Phe Ser Phe Val Glu Ser Lys Lys Glu Asn Lys Asp 
            340                 345                 350         


Arg Met Ser Glu Ile Ile Val Lys Ile Lys Glu His Tyr Lys Lys Asn 
        355                 360                 365             


Val Asn Val Glu Glu Glu Leu Lys Asn Lys Glu Lys Tyr Ile Leu Ser 
    370                 375                 380                 


Leu Ile His Asn Tyr Val Lys Gly Arg Tyr Gly Lys Cys Leu Glu Leu 
385                 390                 395                 400 


Gln Gln Lys Glu Asn Val Asp Phe Glu Asn Leu Gly Lys Arg Ile Lys 
                405                 410                 415     


Glu Ile Phe Asp Ser Asn Glu Val Thr Glu Lys Leu Lys Lys Ser Ile 
            420                 425                 430         


Ile Asn Lys Val Asn Asn Tyr Lys Ile Phe Glu Thr Lys Phe Gln Asn 
        435                 440                 445             


Pro Asn Ile Glu Ser Ser Asp Asp Leu Glu Ile Leu Lys Ala Glu Glu 
    450                 455                 460                 


Thr Phe Leu Asn Lys Leu Ser Thr Ala Val Ser Lys Val Gly Tyr Thr 
465                 470                 475                 480 


Leu Asn Ile Leu Leu Asp Thr Arg Thr Thr Ser Lys Lys Met Asn Lys 
                485                 490                 495     


Lys Lys Ile Lys Asn Pro Asp Ile Leu Ala Gly Tyr Asn Val Thr Ile 
            500                 505                 510         


Glu Leu Leu Pro Tyr Cys Ser Phe Glu Ile Leu Tyr Asn Val Tyr Pro 
        515                 520                 525             


Glu Ile Lys Lys Asp Ile Glu Leu Leu Lys Gly Met Val Leu Phe Ile 
    530                 535                 540                 


Gln Glu Phe Arg Gln Lys Ile Leu His Pro Ser Gln Leu Leu Gly Ser 
545                 550                 555                 560 


Asn Val Lys Lys Ser Ile Ser Ile Lys Glu Lys Asp Thr Ile Val Lys 
                565                 570                 575     


Ile His Glu Asp Asn Lys Asp Asn Glu Lys Arg Glu Met Tyr Asn Lys 
            580                 585                 590         


Glu Lys Ile Arg Ser Tyr Phe Glu Asp Ile Leu Glu Lys Ile Pro Asp 
        595                 600                 605             


Tyr Phe Ile Glu Lys Tyr Glu Ser Asp Asn Val Phe Asn Ile Tyr Arg 
    610                 615                 620                 


Asp Phe Gly Val Lys Ile Met Glu Val Val Lys Asn Phe Asn Phe Lys 
625                 630                 635                 640 


Glu Asn Asn Thr Ile Asp Tyr Leu Phe Pro Lys Phe His Lys Ile Tyr 
                645                 650                 655     


Lys Arg Met Cys Lys Leu Glu Asn Ile Asp Asp Arg Gln Asn Gly Ala 
            660                 665                 670         


Arg Lys Tyr Leu Leu Gln Thr Ile Tyr Tyr Tyr Tyr Phe Gln Tyr Glu 
        675                 680                 685             


Ile Glu Asn Asp Lys Asn Asn Ile Ser Lys Tyr Leu Asn Leu Tyr Arg 
    690                 695                 700                 


Asn Lys Ile Lys Val Lys Lys Ile Ser Tyr Ser Tyr Ile Thr Asp Asn 
705                 710                 715                 720 


Lys Ala Val Asn Asn Lys Asn Ile Glu Ile Leu Tyr Arg Asn Ile Gln 
                725                 730                 735     


Arg Glu Gly Met Leu Asn Asn Lys Leu Ser Gln Met Asn Lys Glu Trp 
            740                 745                 750         


Ile Glu Phe Ile Val Val Gln Phe Ser Glu Phe Leu Thr Asn Lys Lys 
        755                 760                 765             


Leu Asn Trp Ile Leu Asp Asn Leu Ser Glu Tyr Lys Lys Lys Glu Lys 
    770                 775                 780                 


Leu Asp Glu Asn Asp Lys Asn Arg Leu Leu Lys Ile Leu Lys Gln Lys 
785                 790                 795                 800 


Met Asn Lys Lys Ile Ile Tyr Ser Asn Asp Ser Tyr Ala Phe Ile Ser 
                805                 810                 815     


Leu Ala Gln Phe Leu Asp Leu Lys Glu Ile Ser Asn Leu Ile His Asp 
            820                 825                 830         


Ile Lys Lys Phe Ile Gln Phe Arg Glu Lys Asn Val Ser Lys Tyr Lys 
        835                 840                 845             


Pro Glu Lys Asn Lys Leu Tyr Ile Lys Glu Leu Arg Lys Val Leu Tyr 
    850                 855                 860                 


Ile Leu Lys Val Met Leu Glu His Lys Glu Arg Val Ile Gln Lys His 
865                 870                 875                 880 


Tyr Leu Glu Ser Tyr Asp Glu Asn Ile Ser Ile Ile Tyr Gly Lys Asp 
                885                 890                 895     


Ile Glu Arg Lys Asp Ile Lys Asp Ile Lys Ile Lys Ile Lys Asn Glu 
            900                 905                 910         


Asn Gln Glu Val Ile Asn Gln Pro Leu Tyr Lys Ser Gly Asn Asp Glu 
        915                 920                 925             


Asn Ser Ser Trp Ile Val Leu Tyr Gly Ile Glu Gln Ala Lys Arg Asn 
    930                 935                 940                 


Gly Thr Phe Lys Phe Phe Glu Gly Phe Phe Asn Leu Asn Asp Asp Ile 
945                 950                 955                 960 


Lys Leu Cys Lys Glu Asn Ile Glu Lys Tyr Glu Glu Leu Tyr Asn Glu 
                965                 970                 975     


Lys Glu Glu Asn Gln Arg Lys Val Asp Glu Tyr Ile Ser Ser Glu Glu 
            980                 985                 990         


Asn Asn Asn Ile Asp Glu Ile Lys  Glu Ile Asn Asn Asn  Lys Gln Leu 
        995                 1000                 1005             


Phe Tyr  Tyr Tyr Lys Asn Met  Ile Tyr Gly Asp Gly  Leu Lys Lys 
    1010                 1015                 1020             


Gly Tyr  Asp Phe Ile Asn Asp  Ile Tyr Ser His Tyr  Leu Ser Trp 
    1025                 1030                 1035             


Ala Tyr  Arg Val Glu Arg Asp  Cys Lys Ile Tyr Lys  Ile Lys Glu 
    1040                 1045                 1050             


Tyr Glu  Asn Lys Lys Asn Phe  Asn Glu Tyr Lys Phe  Lys Glu Tyr 
    1055                 1060                 1065             


Lys Ser  Ile Lys Asn Phe Arg  Asn Glu Ile Ala His  Phe Asn Tyr 
    1070                 1075                 1080             


Phe Gln  Lys Thr Asn Lys Ser  Leu Leu Glu Leu Leu  Asn Asp Phe 
    1085                 1090                 1095             


Tyr Asp  Ile Phe Asp Tyr Asn  Leu Lys Tyr Gln Arg  Asp Val Gln 
    1100                 1105                 1110             


Asn Val  Ile Asn Asn Ile Phe  Glu Lys Tyr Gln Ile  Val Arg Lys 
    1115                 1120                 1125             


Asp Gly  Gly Pro Val Val Phe  Tyr Cys Lys Thr Asp  Lys Lys Leu 
    1130                 1135                 1140             


Lys Leu  Ser Glu Asn Ile Ile  Pro Lys Lys His Leu  Lys Tyr Pro 
    1145                 1150                 1155             


Glu Ile  Lys Leu Ile His Glu  Lys Tyr Val Glu Phe  Phe Lys Lys 
    1160                 1165                 1170             


Leu Phe  Glu Tyr Lys Lys 
    1175                 


<210>  553
<211>  1380
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  553

Met Lys Leu Ser Lys Glu Lys Gln Ile Arg Ser Ala Val Ala Asn Lys 
1               5                   10                  15      


Glu Lys Asn Thr Glu Gly Val Leu Tyr Arg Phe Pro Gly Asp Asp Ile 
            20                  25                  30          


Gly Gly Val Gln Ala Gln Met Leu Val Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Leu Gly Asn Lys Pro Lys Glu 
    50                  55                  60                  


Trp Met Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Lys Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Ala Ile Asn Asp Ile Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Lys Glu Ala Asp Lys Lys Ile Arg Asn Met Ser Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Asn Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Ser Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Gly Asn Gln Glu Phe Asp Ser Ile Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Asp Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Ser Ile Gln Asp Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Ile Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Glu Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Asp Gly Leu Asn Glu Phe Met Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Glu Glu Lys Arg Ala Glu Val Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Ile His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Val Asn Lys Gly Lys Phe Tyr Val Trp 
305                 310                 315                 320 


Lys Lys His Glu Cys Gly Lys Lys Glu Asn Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Val Glu Ala Glu Ala Glu Ser Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Ile Phe Phe Glu Asn Asp Thr Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Thr Gly Thr Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Lys Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asn Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Gln Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Leu 
            660                 665                 670         


Val Arg Thr Val Phe Pro Glu Tyr Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Asn Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Arg Thr Leu Arg Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Lys 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Glu Asn Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Cys Ala Gln Asp 
            900                 905                 910         


Ile Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu 
        915                 920                 925             


Leu Ser Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Lys Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Lys Phe Ser Glu Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Thr Asn Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Gly  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Glu Lys Pro Glu  Glu Tyr Glu Lys Ile  Glu Ala Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Ile  Tyr Ala Pro Glu Lys  Asn Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Gln Gly Arg Val Gly  Ala Lys Val 
    1145                 1150                 1155             


Thr Ser  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Glu Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Met Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Val Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Val Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Glu Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asn Ala 
    1280                 1285                 1290             


Lys Asp  Lys Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Asp  Ala Glu Asp Ala Asp  Ser Lys Lys Pro Val  Ile Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Glu  Asp Glu Asp 
    1325                 1330                 1335             


Lys Gln  Lys Gly Lys Glu Asn  Arg Gly Lys Lys Asn  Thr Glu Thr 
    1340                 1345                 1350             


Arg Ser  Asp Ala Glu Lys Asn  Asn Asn Glu Arg Leu  Ser Tyr Asn 
    1355                 1360                 1365             


Pro Phe  Ala Asn Phe Asp Phe  Lys Leu Pro Asn Lys  
    1370                 1375                 1380 


<210>  554
<211>  1389
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  554

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Lys Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn Gln Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Ile Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Asn Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Val Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Phe Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Gln Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Lys Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asp Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Val 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Met Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Cys Ile  Ser Ser Ile Lys Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Thr Leu Ile Thr Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Leu Leu Tyr  Tyr Pro Asp 
    1310                 1315                 1320             


Ile Glu  Ser Asn Val Lys Ile  Leu Leu Arg Lys Asp  Asn Phe Asn 
    1325                 1330                 1335             


Gln Asn  Lys Asp Lys Lys Asn  Val Asn Asn Arg Lys  Thr Lys Asn 
    1340                 1345                 1350             


Asn Asn  Lys Asn Gly Asn Arg  Asn Arg Asp Lys Asn  Arg Asp Lys 
    1355                 1360                 1365             


Asn Gly  Gly Gly Asp Gly Leu  Thr Tyr Asn Pro Phe  Leu Asn Leu 
    1370                 1375                 1380             


Ile Phe  Asp Leu Pro Glu 
    1385                 


<210>  555
<211>  1268
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  555

Met Lys Val Ser Lys Val Lys His Arg Arg Thr Ala Val Ser Val Asn 
1               5                   10                  15      


Lys Lys Asn Asn Thr Val Lys Gly Ile Leu Tyr Asp Asp Pro Ile Lys 
            20                  25                  30          


Lys Asp Ser Lys Gly Asp Gly Ala Ser Ala Tyr Val Ser Thr Lys Tyr 
        35                  40                  45              


Val Val Asp Asp Val Val Arg Asn Ser Ser Arg Leu Tyr Ser Pro Phe 
    50                  55                  60                  


Asn Ser Lys Lys Leu Ile Ile Asp Asp Lys Thr Lys Val Val Ala Asn 
65                  70                  75                  80  


Ser Leu Arg Gln His Phe Lys Asn Phe Val Lys Ile Tyr Leu Asn Cys 
                85                  90                  95      


Glu Ser Ile Asp Glu Gln Gln Met Lys Phe Thr Pro Asp Asn Lys Tyr 
            100                 105                 110         


Leu Met Asp Asn Arg Val Arg Ile Ser Leu Pro Ser Asp Val Asn Glu 
        115                 120                 125             


Glu Lys Leu Val Glu Ala Ile Val Asn Ser Ser Leu Arg Lys Ser Leu 
    130                 135                 140                 


Asn Lys Lys Cys Asn Ile Gln Ile Lys Ala Gly Leu Arg Glu Thr Phe 
145                 150                 155                 160 


Asp Ile Pro Glu Leu Ile Lys Lys Ala Ile Lys Ile Tyr Cys Ile Asp 
                165                 170                 175     


Glu Lys Arg Asn Leu Asn Asp Ala Glu Lys Leu Asp Met Tyr Ala Leu 
            180                 185                 190         


Phe Ser Phe Met Tyr Glu Asp Lys Tyr Lys Asn Arg Gln Lys Lys Leu 
        195                 200                 205             


Ile Ile Asn Ser Ile Ser Asn Gln Val Thr Lys Val Lys Val Cys Glu 
    210                 215                 220                 


Asn Gly Asn Arg Leu Leu Lys Leu Ser Ile Ala Asp Thr Lys Lys Lys 
225                 230                 235                 240 


Pro Leu Trp Asp Phe Met Ile Glu Tyr Ser Asn Ser Asp Lys Lys Lys 
                245                 250                 255     


Gln Asp Thr Met Leu Arg Asn Ile Arg Lys Ser Ile Val Leu Phe Val 
            260                 265                 270         


Cys Gly Val Glu Asn Tyr Lys Asn Ile Glu Asn Asp Asn Lys Leu Asp 
        275                 280                 285             


Ile Cys Ser Trp Asp Gly Tyr Asp Ile Asn Glu Asn Gln Gln Phe Val 
    290                 295                 300                 


Cys Val Asn Thr Asn Asn Ser Asn Asp Asp Tyr Phe Ile Ser Ser Thr 
305                 310                 315                 320 


Glu Leu Arg Arg Ala Asn Leu Asp His Tyr Met Lys Ala Val Ala Lys 
                325                 330                 335     


Leu Asn Asp Asp Arg Asn Lys Phe Trp Phe Gln His Phe Glu Ser Val 
            340                 345                 350         


Ile Glu Thr Phe Phe Ser Lys Lys Ala Lys Arg Asn Ile Glu Arg Ile 
        355                 360                 365             


Lys Ser Ala Tyr Leu Cys Glu Tyr Leu Trp Arg Asp Phe Cys Ser Tyr 
    370                 375                 380                 


Val Ala Leu Lys Tyr Val Asp Leu Gly Lys Gly Val Tyr His Phe Thr 
385                 390                 395                 400 


Met Ala Asp Lys Leu Ala Leu Ile Asn Arg Asn Lys Tyr Glu Lys Ser 
                405                 410                 415     


Ile Ile Phe Gly Glu Ile Glu Ser Arg Tyr Asn Asn Gly Ile Ser Ser 
            420                 425                 430         


Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Leu Phe Glu Arg Asn Ile 
        435                 440                 445             


Ser Thr Tyr Thr Thr Phe Ala Thr Asn Ile Phe Ser Lys Ala Val Val 
    450                 455                 460                 


Gln Asp Asp Tyr Ile Lys Asn His Asn Lys Ala Ser Asp Val Leu Gln 
465                 470                 475                 480 


Tyr Ser Asp Lys Glu Phe Ser Asp Ser Lys Val Leu Arg Asn Asp Ala 
                485                 490                 495     


Met Lys Arg Ile Leu Gln Tyr Trp Gly Gly Gln Ser Arg Trp Asn Asn 
            500                 505                 510         


Thr Leu Asn Lys Ile Asn Val Asp Thr Leu Cys Ile Asp Ile Lys Glu 
        515                 520                 525             


His Leu Ser Asn Ile Arg Asn Ser Ser Val His Tyr Thr Ser Lys Val 
    530                 535                 540                 


Ser Leu Ser Gly Asp Lys Asn Glu Ser Ile Val Tyr Met Leu Phe Lys 
545                 550                 555                 560 


Lys Asp Phe Ala Glu Ile Arg Asn Ile Phe Ala Ser Lys Tyr Tyr Ser 
                565                 570                 575     


Asn Asn Val Trp Met Phe Tyr Ser Ile Glu Lys Ile Asn Gly Leu Met 
            580                 585                 590         


Glu Tyr Leu Tyr Gly Asp Asn Ser Thr Val Ile Asp Ala Gln Ile Pro 
        595                 600                 605             


Ala Tyr Asn Asn Ile Ile Lys Arg Lys Asn Ile Ala Asp Val Ile Glu 
    610                 615                 620                 


Lys Ile Ile Lys Lys Asn Ser Tyr Lys Thr Ile Asn Glu Leu Glu Leu 
625                 630                 635                 640 


Ile Lys Lys Tyr Arg Ala Cys Leu Tyr Phe Ile Leu Lys Glu Ile Tyr 
                645                 650                 655     


Tyr Asn Arg Phe Ile Lys Gln Glu Asn Leu Lys Glu Gln Phe Ile Gln 
            660                 665                 670         


Phe Val Asp Asn Asp Asn Asn Leu Leu Asp Asp Asn Lys Asn Ala Val 
        675                 680                 685             


Glu Ser Phe Arg Arg Arg Ile His Asp Ile Asp Asn Ser Leu Met Ser 
    690                 695                 700                 


Phe Gly Glu Met Cys Gln Phe Ile Met Thr Asp Tyr Asn Met Gln Asn 
705                 710                 715                 720 


Gln Gly Asn Lys Ser Ile Lys Ser Lys Asp Arg Gln Asn Glu Asp Lys 
                725                 730                 735     


Lys Lys Gly Ile Asp Gly Ser Tyr Lys His Phe Pro Leu Leu Leu Tyr 
            740                 745                 750         


His Val Ile Lys Glu Leu Phe Leu Lys Tyr Ile Lys Thr Asp Glu Lys 
        755                 760                 765             


Ile Val Phe Ile Arg Glu Pro Ala Asn Ile Gly Ser Val Lys Thr Gln 
    770                 775                 780                 


Asp Glu Phe Glu Thr His Ile Ser Thr Leu Gly Leu Tyr Lys Thr Leu 
785                 790                 795                 800 


Lys Glu Lys Val Asp Ser Asn Met Ser Leu Leu Asp Trp Tyr Thr Leu 
                805                 810                 815     


Ser His Phe Leu Met Pro Lys Gln Leu Asn Tyr Leu Ile Gly Asp Ile 
            820                 825                 830         


Lys Asn Tyr Ile Gln Tyr Leu Arg Asn Ile Asp Lys Arg Ala Glu Ser 
        835                 840                 845             


Val Gly Asn Asn Lys Ala Tyr Asp Ile Asp Gly Lys Ile Asn Asn Tyr 
    850                 855                 860                 


Tyr Asp Ile Val Tyr Val Leu Asp Phe Ser Leu Gln Tyr Ile Gly Arg 
865                 870                 875                 880 


Ile Ser Asn Glu Ile Thr Asp Tyr Phe Ala Asp Glu Asp Glu Tyr Ala 
                885                 890                 895     


Leu Phe Met Ser Gln Phe Val Asp Phe Ser Ser Asp Asn Ile Val Gly 
            900                 905                 910         


Leu Lys Thr Phe Cys Asn Glu Lys Thr Ser Asn Gly Lys His Thr Ile 
        915                 920                 925             


Gly Leu Tyr Cys Asp Gly Ala Asn Pro Ile Met Asn Arg Asn Ile Ala 
    930                 935                 940                 


Tyr Ala Lys Met Tyr Ser Asn Asp Lys Ile Leu Ser Arg Thr Tyr Ser 
945                 950                 955                 960 


Lys Val Thr Ile Lys Glu Ile Glu Arg Tyr Tyr Arg Ile Gln Asp Asp 
                965                 970                 975     


Leu Lys Asn Val Phe Glu Asn Gly Val Cys Lys Asn Lys Asp Gln Gln 
            980                 985                 990         


Lys Glu Leu Cys Asp Phe Gln Lys  Ile Lys Asn His Ile  Glu Leu Thr 
        995                 1000                 1005             


Glu Ile  Ser Ile Tyr Thr Asn  Ile Leu Asn Asp Phe  Met Ser Gln 
    1010                 1015                 1020             


Phe Ile  Ser Trp Ser Tyr Leu  Arg Glu Arg Asp Leu  Met Tyr Phe 
    1025                 1030                 1035             


Gln Leu  Gly Met His Tyr Leu  Arg Leu Tyr Tyr Gly  Thr Asn Glu 
    1040                 1045                 1050             


Leu Glu  Thr Lys Tyr Asn Lys  Leu Val Gly Glu Ser  Val Asn Ile 
    1055                 1060                 1065             


Glu Lys  Gly Ala Leu Leu Tyr  Gln Ile Ala Ala Met  Tyr Thr Tyr 
    1070                 1075                 1080             


Lys Leu  Pro Ile Tyr Lys Val  Asp Lys Asn Gly Ser  Ala Val Leu 
    1085                 1090                 1095             


Ala Glu  Lys Gln Gly Gly Thr  Gly Ala Ser Val Thr  Ser Phe Val 
    1100                 1105                 1110             


Thr Glu  Tyr Cys Lys Glu Asn  Met Arg Asp Ala Ile  Ile Tyr Glu 
    1115                 1120                 1125             


Lys Gly  Leu Glu Leu Phe Glu  Asp Val Lys Gln His  Lys Lys Trp 
    1130                 1135                 1140             


Ser Asp  Phe Arg Asn Asp Ile  Ala His Met Arg Tyr  Ile Ser Asp 
    1145                 1150                 1155             


Arg Asp  Lys Ser Ile Met Asp  Ile Ile Ser Glu Ile  Tyr Gly Gly 
    1160                 1165                 1170             


Phe Phe  Thr Tyr Asp Ile Lys  Leu Lys Lys Ser Ile  Pro Val Ile 
    1175                 1180                 1185             


Phe Lys  Asn Ile Leu Met Arg  Tyr Ala Val Asp Ala  Asn Leu Asn 
    1190                 1195                 1200             


Phe Leu  His Lys Glu Asn Arg  Lys Leu Lys Asp Thr  Leu Ile Asn 
    1205                 1210                 1215             


Ile Arg  Ala Asp Lys Gly Leu  Val Ser Asp Lys Tyr  Thr Tyr Lys 
    1220                 1225                 1230             


Ile Gly  Glu Lys Asp Thr Val  Asp Ile Glu Val Arg  Asn Asp Lys 
    1235                 1240                 1245             


Phe Leu  Leu Gln Leu Arg Lys  Leu Leu Glu Tyr Lys  Ile Arg Val 
    1250                 1255                 1260             


Asn Gly  Asn Val Leu 
    1265             


<210>  556
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  556

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Ile Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Phe Asp Phe Lys Leu  Leu Asn 
    1400                 1405                 1410         


<210>  557
<211>  1353
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  557

Met Lys Val Thr Lys Ala Glu Lys Leu Arg Val Ala Val Ser Arg Lys 
1               5                   10                  15      


Leu Asn Asn Glu Asp Lys Arg Ala Val Leu Tyr Lys Thr Pro Asn Pro 
            20                  25                  30          


Gly Gln Thr Cys Gly Thr Val Lys Lys Gln Leu Ala Asn Arg Val Glu 
        35                  40                  45              


Arg Ala Asn Lys Leu Tyr Gly Val Phe Phe Arg Ser Asp Val Pro Glu 
    50                  55                  60                  


Thr Leu Gln Tyr His Phe Glu Glu Leu Val Thr Tyr Ala Ala Gln Ser 
65                  70                  75                  80  


Thr Ser Pro Asn Glu Phe Arg Gln Lys Ala Ser Gln Tyr Arg Glu Cys 
                85                  90                  95      


Glu Lys Lys Asp Lys Phe Gly Lys Met Arg Lys Tyr Pro Ile Phe Arg 
            100                 105                 110         


Cys Ser Tyr Ala Pro Ser Gly Lys Asn Met Lys Lys Val Met Glu Leu 
        115                 120                 125             


Tyr Val Arg Glu Arg Met Lys Asp Glu Trp Gln Ser Gln Ala Tyr Arg 
    130                 135                 140                 


Thr Ala Ala Ile Glu Ile Leu Leu Cys Ile Cys Asn Lys Asp Phe Ser 
145                 150                 155                 160 


Lys Gln Leu Ser Arg Val Asp Ala Arg Ile Phe Ala Asp Phe Tyr Asn 
                165                 170                 175     


Ala Ser Lys Ala Cys Pro Gln Pro Tyr Ile Gly Lys Ser Thr Gly Val 
            180                 185                 190         


Leu Glu Ala Ala Phe Thr Ser Val Met Lys Gln Met Ser Leu His Ala 
        195                 200                 205             


Lys Ala Asn Ala Ser Asn Lys Ile Trp Trp Leu Gln Asn Gln Leu Arg 
    210                 215                 220                 


Thr Ile Glu Leu Asn Lys Lys Ile Val Lys Ile Ser Asp Phe Lys Tyr 
225                 230                 235                 240 


Glu Tyr Ala Thr Glu Asp Arg Met Arg Ala Ile Leu Val Arg Met Arg 
                245                 250                 255     


Lys Ser Leu Lys Arg Gly Thr Asn Gly Asp Ile Ala Val Ala Leu Leu 
            260                 265                 270         


Gln Gly Ile Ala Gln Met Asn Gly Lys Thr Leu Ser Gly Val Leu Glu 
        275                 280                 285             


Glu Leu Ser Ala Asn Ser Glu Thr Lys Glu Gln Leu Ile Lys Phe Leu 
    290                 295                 300                 


Lys Ala Val His Glu Asp Tyr His Lys Thr Pro Ile Leu Lys Ala Ile 
305                 310                 315                 320 


Arg Asn Gln Asp Val Lys Val Gln Val His Glu Val Asp Pro Val Ser 
                325                 330                 335     


Pro Glu Gly Arg Ala Leu Asp Leu Ala Ser Ile Asn Val Ser Lys Gly 
            340                 345                 350         


Asn Glu Arg Lys Lys Tyr Lys Val Ala Leu Thr Gln Thr Leu Gly Asn 
        355                 360                 365             


Tyr Ala Lys Ser Pro Lys Asp Ala Thr Gln Thr Leu Lys Ala Ile Lys 
    370                 375                 380                 


Gly Val Leu Leu Asp Tyr Phe Met Trp Leu Asp Ser Asp Val Lys Ala 
385                 390                 395                 400 


Glu Phe Leu Glu Asp Asn Asn Leu Trp Lys Ile Pro Asn Arg Thr Glu 
                405                 410                 415     


Glu Tyr Phe Asp Asn Asn Phe Val Pro Ile Asp Asp Lys Lys Asp Asp 
            420                 425                 430         


Lys Ile Glu Ala Ile Glu Asp Phe Ala Ser Ile Trp Arg Gln Glu Arg 
        435                 440                 445             


Val Lys Asn Ser Arg Ile Lys Ala Arg Met Asn Tyr Val Asn Cys Gly 
    450                 455                 460                 


Lys Tyr Gln Gln Leu Ile Lys Gln Glu Thr Asp Asp Phe Arg Ile Cys 
465                 470                 475                 480 


Trp Ile Ser Tyr Ala Lys Asp Phe Val Glu Lys Asn Tyr Val Ser Lys 
                485                 490                 495     


Asn Arg Gln Phe Thr Gln Gly Asp Cys Phe Ser Thr Lys Met Leu Leu 
            500                 505                 510         


Glu Cys Trp Lys Glu Ile Ile Arg Phe Ile Cys Gly Lys Tyr Ile Asp 
        515                 520                 525             


Ile Gly Lys Ala Val Tyr His Phe Ala Met Pro Glu Thr Met Asn Ala 
    530                 535                 540                 


Arg Asp Ser Leu Ala Tyr Gly Val Leu Gly Glu Lys Tyr Lys Glu Gly 
545                 550                 555                 560 


Ile Ser Ser Phe Asp Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln 
                565                 570                 575     


Arg Asp Ile Ala Lys Ala Ala Val Ala Ala Ile His Ala Phe Ser Gly 
            580                 585                 590         


Ser Val Ile Asp Asp Lys Lys Pro Val Glu Asp Ile Leu Phe Ile Lys 
        595                 600                 605             


Asp Glu Glu Leu Gln Glu His Ala Lys Ala Asp Asp Val Ile Val Lys 
    610                 615                 620                 


Gln Ile Leu Arg Phe Tyr Gly Gly Phe Ser Ser Val Glu Gly Arg Glu 
625                 630                 635                 640 


Lys Leu Glu Gly Met Ala Leu Ala Lys Glu Val Leu Ser Gln Leu Lys 
                645                 650                 655     


Ala Ile Arg Asn Glu Asn Phe His Phe Thr Gln Gly Lys Arg Lys Asn 
            660                 665                 670         


Val Glu Glu Asn Ile Pro Leu Thr Lys Ala Leu Trp Glu Asn Glu Glu 
        675                 680                 685             


Lys Val Tyr Arg Gln Thr Val Lys Glu Thr Tyr Tyr Ser Asn Asn Val 
    690                 695                 700                 


Ser Met Phe Tyr Ser Gln Glu Val Ile Gln Lys Leu Val Ala Glu Leu 
705                 710                 715                 720 


Tyr Gln Asn Asn Asn Val Ala Glu Ala Gln Ile Pro Ala Phe Arg Thr 
                725                 730                 735     


Ile Trp Lys Arg Lys Asp Leu Pro Glu Tyr Ile Gly Ser Leu Asn Ile 
            740                 745                 750         


Ser Trp Asp Lys Thr Glu Pro Lys Gln Val Ile Tyr Glu Gly Ala Leu 
        755                 760                 765             


Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Lys Ser Gly 
    770                 775                 780                 


Glu Ala Lys Lys Leu Phe Phe Asp Ala Val Met Asp Asn Ala Thr Glu 
785                 790                 795                 800 


Met Glu Lys Ser Ser Asn Ala Asp Ser Arg Asn Gln Glu Lys Lys Ala 
                805                 810                 815     


Leu Ala Asn Ala Gly Lys Asn Phe Arg Asp Tyr Val Asn Gly Leu Asn 
            820                 825                 830         


Ala Ser Thr Leu Gly Glu Val Cys Gln Phe Ile Gln Asn Glu Tyr Asn 
        835                 840                 845             


Gln Gln Asn Arg Gly Lys Gln Glu Gln Glu Ile Tyr Lys His Phe Lys 
    850                 855                 860                 


Met Leu Leu Pro Ile Cys Met Arg Lys Ala Phe Gln Arg Tyr Ile Asp 
865                 870                 875                 880 


Glu Lys His Ser Phe Ile Lys Lys Pro Gly Glu Leu Pro Gln Thr Thr 
                885                 890                 895     


Glu Asp Tyr Leu Glu Asn Val Lys Val Ala Cys Pro Glu Lys Lys Ile 
            900                 905                 910         


Lys Leu Gly Arg Trp Phe Thr Phe Ala His Phe Ile His Pro Arg Glu 
        915                 920                 925             


Leu Asn Phe Leu Ile Gly Asp Phe Lys Asn Tyr Ile Gln Tyr Arg Glu 
    930                 935                 940                 


Asp Val Leu Arg Arg Ser Glu His Ala Gly Gln Phe Ser Asp Thr Thr 
945                 950                 955                 960 


Glu Arg Asp Gly Glu Lys Ala Val Val Asp His Ala Val Gln Lys Ala 
                965                 970                 975     


Lys Asp Ile Leu Gly Val Leu Glu Phe Val Arg His Ile Ser Gly Arg 
            980                 985                 990         


Val Ser Asn Glu Phe Thr Asp Tyr  Tyr Ala Asp Arg Ala  Glu Tyr Asp 
        995                 1000                 1005             


Glu Tyr  Met Ala Lys Tyr Phe  Glu Pro Asp Val Gln  Ile Glu Gln 
    1010                 1015                 1020             


Tyr Asp  Leu Tyr Gly Asp Ala  Lys Asn Ala Lys Val  Ile Arg Asn 
    1025                 1030                 1035             


Ile Glu  Leu Ala Arg Met Tyr  Ala Gly Asp Ser Leu  Met Ser Ala 
    1040                 1045                 1050             


Ser Tyr  Arg Lys Ile Thr Lys  Lys Glu Ile Glu Thr  Tyr Tyr Ala 
    1055                 1060                 1065             


Lys Lys  Asp Glu Ile Ala Gln  Leu Gln Ser Gln Gly  Ile Cys Asn 
    1070                 1075                 1080             


Ser Lys  Lys Glu Gln Glu Asp  Ile Val Ala Phe Gln  Lys Leu Lys 
    1085                 1090                 1095             


Asn Arg  Ile Thr Leu Asn Glu  Val Thr Asp Leu Trp  Ser Leu Val 
    1100                 1105                 1110             


Asn Glu  Leu Leu Gly Asn Leu  Val Ser Leu Ala Tyr  Leu Arg Glu 
    1115                 1120                 1125             


Arg Asp  Glu Met Tyr Leu Phe  Leu Gly Phe Tyr Tyr  Met Ala Leu 
    1130                 1135                 1140             


Arg His  Pro Glu Gly Trp Thr  Asn Glu Ile Met Asn  Ser Val Ser 
    1145                 1150                 1155             


Asn Glu  Lys Tyr Ala Val Lys  Glu Gly Leu Val Leu  Tyr Gln Thr 
    1160                 1165                 1170             


Val Ala  Val Phe Asp Phe Gly  Thr Lys Leu Leu Phe  Gln Asn Asp 
    1175                 1180                 1185             


Asn Gln  Lys Trp Glu Glu Thr  Thr Gly Tyr Lys Trp  Gln His Phe 
    1190                 1195                 1200             


Ile Asp  Asn His Lys Glu Ser  Tyr Ala Cys Ile Leu  Pro Leu Phe 
    1205                 1210                 1215             


Glu Ile  Ala Lys Cys Glu Thr  Glu Ala Arg Ala Val  Arg Asn Tyr 
    1220                 1225                 1230             


Val Asp  His Phe Lys Tyr Tyr  Ser Asn Glu Asp Arg  Ser Ile Leu 
    1235                 1240                 1245             


Glu Leu  Tyr Gly Lys Phe Tyr  Thr His Leu Phe Gly  Tyr Ser Thr 
    1250                 1255                 1260             


Arg Leu  Arg Lys Ser Val Leu  Gln Ile Leu Ala Gln  Thr Leu Glu 
    1265                 1270                 1275             


Lys His  Gly Ile Ser Ala Gly  Ile Gln Phe Asp Gly  Thr Thr Val 
    1280                 1285                 1290             


Lys Ala  Thr Arg Cys Asp Met  Lys Ser Val Glu Phe  Thr Tyr Lys 
    1295                 1300                 1305             


Tyr Glu  Glu Lys Leu Asn Glu  Gln Lys Thr Val Leu  Arg Thr Ile 
    1310                 1315                 1320             


Ser Leu  Pro Ala Lys Ser Glu  Gly Phe Ile Thr Ala  Val Cys Glu 
    1325                 1330                 1335             


Met Leu  Lys Gln Lys Lys Gly  Asp His Thr Glu Asn  Thr Leu Cys 
    1340                 1345                 1350             


<210>  558
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  558

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Leu Tyr Gln Ile Val  Ser Ala Phe Asn Phe  Gly Ser Lys 
    1205                 1210                 1215             


Leu Leu  Tyr Ile Ser Glu Asp  Gly Arg Trp Lys Met  Ala Gly Gly 
    1220                 1225                 1230             


Ala Phe  Pro Gly Lys Tyr Gly  Arg Phe Glu Asn Asp  Tyr Asn His 
    1235                 1240                 1245             


Arg Thr  Ser Leu Ser Lys Val  Ile Arg Leu Phe Glu  Asn Glu Ser 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ile Ile Tyr  Trp Arg Asp Tyr Val  Asp His Met 
    1265                 1270                 1275             


Lys Tyr  Tyr Val Asn Gln Asn  Gln Ser Ile Met Glu  Ile Tyr Ser 
    1280                 1285                 1290             


Ala Phe  Tyr Ser Lys Val Leu  Gly Tyr Ser Ala Lys  Leu Arg Lys 
    1295                 1300                 1305             


Ser Val  Val Phe Asn Leu Gln  Ala Ala Leu Glu Lys  His His Ile 
    1310                 1315                 1320             


Asn Pro  Glu Cys Ile Trp Met  Thr Ser Asp Gly Lys  Cys Ala Asp 
    1325                 1330                 1335             


Ile Lys  Leu Met Lys Asn Leu  Glu Ser Gln Lys Phe  Thr Tyr Lys 
    1340                 1345                 1350             


Leu Ala  Lys Arg Glu Gly Glu  Lys Thr Glu Arg Lys  Ile Cys Met 
    1355                 1360                 1365             


Asn Ala  Leu Asn Glu Asn Phe  Leu Lys Thr Ile Arg  Thr Ser Leu 
    1370                 1375                 1380             


Glu Tyr  Lys Lys 
    1385         


<210>  559
<211>  1391
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  559

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Lys Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Phe Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn Gln Ile Gln Thr Gly Thr Lys Pro Lys Glu Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Lys Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Ile Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Asn Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Val Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Phe Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Gln Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Glu Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Ala Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Lys Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Ser Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Leu Tyr Leu Gln Asn Asn Lys Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Met Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Cys Ile  Ser Ser Ile Lys Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Thr Leu Ile Thr Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Gly  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Gly Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Asn Lys Asn Lys Lys  Asn Lys Lys Asn Asn  Gly Asn Arg 
    1355                 1360                 1365             


Asp Glu  Lys Lys Asn Ser Asp  Gly Leu Thr Tyr Ser  Pro Phe Leu 
    1370                 1375                 1380             


Asp Leu  Pro Phe Glu Leu Pro  Glu 
    1385                 1390     


<210>  560
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  560

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  561
<211>  1196
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  561

Met Lys Val Thr Lys Ile Asp Gly Leu Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Phe Lys Asn Asn Lys Asn Ile Asn Glu Ile 
            20                  25                  30          


Lys Glu Arg Leu Lys Lys Leu Lys Glu Leu Lys Leu Asp Asn Tyr Ile 
        35                  40                  45              


Lys Asn Pro Glu Asn Val Lys Asn Lys Asp Lys Asp Ala Glu Lys Glu 
    50                  55                  60                  


Thr Lys Ile Arg Arg Thr Asn Leu Lys Lys Tyr Phe Ser Glu Ile Ile 
65                  70                  75                  80  


Leu Arg Lys Glu Asp Glu Lys Tyr Ile Leu Lys Lys Thr Lys Lys Phe 
                85                  90                  95      


Lys Asn Ile Asn Gln Glu Ile Asp Tyr Tyr Asp Val Lys Ser Lys Lys 
            100                 105                 110         


Asn Gln Gln Glu Ile Phe Asp Val Leu Lys Glu Ile Leu Gly Leu Lys 
        115                 120                 125             


Ile Lys Glu Thr Glu Lys Glu Glu Ile Ile Thr Phe Asp Ser Glu Lys 
    130                 135                 140                 


Leu Lys Lys Val Phe Gly Glu Asp Phe Val Lys Lys Glu Ala Lys Ile 
145                 150                 155                 160 


Lys Ala Ile Glu Lys Ser Leu Lys Ile Asn Lys Ala Asn Tyr Lys Lys 
                165                 170                 175     


Asp Ser Ile Lys Ile Gly Asp Asp Lys Tyr Ser Asn Val Lys Gly Glu 
            180                 185                 190         


Asn Lys Arg Ser Arg Ile Tyr Glu Tyr Tyr Lys Lys Ser Glu Asn Leu 
        195                 200                 205             


Lys Lys Phe Glu Glu Asn Ile Arg Glu Ala Phe Glu Lys Leu Tyr Thr 
    210                 215                 220                 


Glu Glu Asn Ile Lys Glu Leu Tyr Ser Lys Ile Glu Glu Val Leu Lys 
225                 230                 235                 240 


Lys Thr His Leu Lys Ser Ile Ile Arg Glu Phe Tyr Gln Asn Glu Ile 
                245                 250                 255     


Ile Gly Glu Ser Lys Phe Ser Lys Lys Asn Gly Asp Gly Ile Ser Ile 
            260                 265                 270         


Leu Tyr Asn Gln Ile Lys Asp Ser Ile Lys Lys Glu Glu Asn Phe Ile 
        275                 280                 285             


Glu Phe Ile Glu Asn Ile Gly Asn Leu Glu Leu Lys Asp Leu Thr Lys 
    290                 295                 300                 


Ser Gln Ile Phe Tyr Lys Tyr Phe Leu Glu Asn Glu Glu Leu Asn Asp 
305                 310                 315                 320 


Glu Asn Ile Lys Phe Ala Phe Cys Tyr Phe Val Glu Ile Glu Val Asn 
                325                 330                 335     


Asn Leu Leu Lys Glu Asn Val Tyr Lys Ile Lys Arg Phe Asn Glu Gly 
            340                 345                 350         


Asn Lys Lys Arg Ile Lys Asn Ile Phe Glu Tyr Gly Lys Leu Lys Lys 
        355                 360                 365             


Leu Ile Val Tyr Lys Leu Glu Asn Lys Leu Asn Asn Tyr Val Arg Asn 
    370                 375                 380                 


Cys Gly Lys Tyr Asn Tyr His Met Glu Asn Gly Asp Ile Ala Thr Ser 
385                 390                 395                 400 


Asp Ile Asn Met Arg Asn Arg Gln Thr Glu Ala Phe Leu Arg Ser Ile 
                405                 410                 415     


Ile Gly Val Ser Ser Phe Gly Tyr Phe Ser Leu Arg Asn Ile Leu Gly 
            420                 425                 430         


Val Asn Asp Asp Asp Phe Tyr Glu Ile Glu Glu Gly Leu Thr Glu Glu 
        435                 440                 445             


Glu Arg Lys Asn Glu Ser Asn Val Leu Lys Lys Ala Lys Glu Asp Ile 
    450                 455                 460                 


Thr Ser Lys Ser Ile Phe Glu Lys Val Val Asp Lys Ser Phe Glu Lys 
465                 470                 475                 480 


Lys Gly Ile Arg Ser Ile Lys Glu Asn Leu Lys Met Phe Tyr Gly Asp 
                485                 490                 495     


Ser Phe Asp Lys Ala Asn Gly Asp Glu Leu Lys Gln Phe Phe Val Asn 
            500                 505                 510         


Met Leu Asn Ala Ile Thr Ser Ile Arg His Ser Val Val His Tyr Asp 
        515                 520                 525             


Met Asn Thr Asn Ser Glu Asn Ile Phe Asn Phe Ser Asp Ile Glu Val 
    530                 535                 540                 


Ser Arg Leu Leu Lys Ser Ile Phe Glu Lys Glu Thr Asp Lys Arg Glu 
545                 550                 555                 560 


Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Gly Val Phe Asp 
                565                 570                 575     


Tyr Trp Glu Asn Leu Lys Ile Lys Lys Tyr Leu Glu Asn Ile Lys Phe 
            580                 585                 590         


Glu Phe Val Asn Lys Asn Val Pro Phe Val Pro Ser Phe Thr Lys Leu 
        595                 600                 605             


Tyr Asn Arg Ile Asp Asn Leu Lys Gly Ser Asn Ala Leu Asn Leu Gly 
    610                 615                 620                 


Tyr Ile Asn Ile Pro Lys Arg Lys Glu Ala Arg Asp Ser Gln Ile Tyr 
625                 630                 635                 640 


Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Val Glu Glu Phe Ile Lys 
                645                 650                 655     


Asn Asn Asp Asn Phe Glu Lys Ile Phe Arg Glu Ile Ile Glu Ile Asn 
            660                 665                 670         


Lys Asn Ala Gly Arg Asn Lys Gln Thr Asn Phe Tyr Lys Leu Glu Lys 
        675                 680                 685             


Phe Glu Lys Leu Lys Ala Asn Thr Pro Thr Glu Tyr Leu Glu Lys Leu 
    690                 695                 700                 


Gln Ser Leu His Lys Ile Asn Tyr Asp Arg Glu Lys Ile Glu Glu Asp 
705                 710                 715                 720 


Lys Asp Ile Tyr Val Asp Phe Val Gln Lys Ile Phe Leu Lys Gly Phe 
                725                 730                 735     


Ile Asn Tyr Leu Gln Lys Ser Asn Ser Leu Lys Pro Leu Asn Leu Leu 
            740                 745                 750         


Asn Leu Lys Lys Asp Glu Ala Val Ala Asn Lys Lys Ser Phe Tyr Asp 
        755                 760                 765             


Glu Lys Leu Lys Gln Trp Glu Asn Asn Gly Ser Asn Leu Ser Glu Met 
    770                 775                 780                 


Pro Lys Glu Ile Tyr Lys Tyr Ile Lys Glu Ile Asn Ile Asn Lys Ile 
785                 790                 795                 800 


Asn Tyr Ser Asn Arg Met Ser Ile Phe Tyr Leu Leu Leu Lys Leu Ile 
                805                 810                 815     


Asp His Arg Glu Leu Thr Asn Leu Arg Gly Asn Leu Glu Lys Tyr Glu 
            820                 825                 830         


Ser Met Asn Lys Asn Lys Ile Tyr Ser Glu Glu Leu Asn Ile Val Asn 
        835                 840                 845             


Leu Val Ser Leu Asp Asn Asn Lys Val Arg Thr Asn Phe Ser Val Glu 
    850                 855                 860                 


Ala Glu Asp Ile Gly Lys Phe Leu Lys Thr Glu Thr Ser Ile Lys Asn 
865                 870                 875                 880 


Asn Lys Gln Leu Asn Asn Phe Ser Glu Ile Phe Ala Asp Gly Glu Asn 
                885                 890                 895     


Val Ile Lys His Arg Ser Phe Tyr Asn Ile Lys Lys Tyr Gly Ile Leu 
            900                 905                 910         


Asp Leu Leu Glu Lys Ile Val Thr Lys Ala Asp Leu Lys Ile Thr Lys 
        915                 920                 925             


Glu Glu Ile Lys Lys Tyr Lys Asn Leu Gln Lys Glu Leu Glu Lys Asn 
    930                 935                 940                 


Asp Phe Tyr Lys Ile Gln Glu Lys Ile His Arg Lys Tyr Asn Gln Lys 
945                 950                 955                 960 


Pro Asn Leu Ile Ser Arg Thr Glu Asn Lys Lys Asp Phe Asn Asp Tyr 
                965                 970                 975     


Lys Lys Ala Ile Glu Asn Ile Gln Asn Tyr Thr Gln Leu Lys Asn Lys 
            980                 985                 990         


Ile Glu Phe Asn Asp Leu Asn Leu  Leu Gln Gly Leu Leu  Phe Arg Ile 
        995                 1000                 1005             


Leu His  Arg Leu Thr Gly Tyr  Thr Ser Leu Trp Glu  Arg Asp Leu 
    1010                 1015                 1020             


Gln Phe  Lys Leu Lys Gly Glu  Phe Pro Glu Asp Lys  Tyr Ile Asp 
    1025                 1030                 1035             


Glu Ile  Phe Asn Ser Asp Arg  Asn Asn Asn Gln Lys  Tyr Lys Ser 
    1040                 1045                 1050             


Gly Gly  Ile Ala Tyr Lys Tyr  Val Asp Phe Leu Ile  Glu Lys Glu 
    1055                 1060                 1065             


Glu Gly  Lys Arg Ala Gly Lys  Asn Lys Val Lys Lys  Arg Ser Glu 
    1070                 1075                 1080             


Lys Glu  Gly Ser Phe Ile Ile  Arg Asn Tyr Ile Ala  His Phe Asn 
    1085                 1090                 1095             


Tyr Ile  Pro Asp Ala Glu Lys  Ser Ile Leu Glu Ile  Leu Glu Glu 
    1100                 1105                 1110             


Leu Arg  Glu Leu Leu Lys Tyr  Asp Arg Lys Leu Lys  Asn Ala Val 
    1115                 1120                 1125             


Met Lys  Ser Val Lys Asp Ile  Phe Lys Glu Tyr Gly  Phe Ile Val 
    1130                 1135                 1140             


Glu Phe  Gly Ile Ser His Glu  Ser Asn Ser Lys Lys  Ile Lys Val 
    1145                 1150                 1155             


Leu Asp  Val Lys Ser Glu Lys  Ile Lys His Leu Lys  Asn Asn Gly 
    1160                 1165                 1170             


Leu Val  Thr Thr Arg Asn Ser  Glu Asp Leu Cys Glu  Leu Val Lys 
    1175                 1180                 1185             


Val Met  Leu Glu Tyr Lys Lys  Ser 
    1190                 1195     


<210>  562
<211>  1407
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  562

Met Gly Asn Leu Phe Gly Tyr Lys Lys Trp Tyr Lys Val Asp Lys Ile 
1               5                   10                  15      


Ile Lys Asp Lys Lys Gly Lys Lys Ser Thr Ile Lys Gln Glu Val Arg 
            20                  25                  30          


Ile Lys Arg Asp Tyr Leu Thr Asn Arg Tyr Ile Leu Asn Thr Asn Asn 
        35                  40                  45              


Lys Asp Lys Asn Asn Ile Asn Asn Lys Asp Phe Val Asn Gln Phe Ile 
    50                  55                  60                  


Glu Tyr Lys Thr Lys Asn Asp Ile Phe Glu Lys Phe Thr Arg Lys Phe 
65                  70                  75                  80  


His Met Gly Asn Ile Leu Phe Lys Leu Lys Ala Lys Glu Ser Val Gly 
                85                  90                  95      


Glu Ile Arg Ser Tyr Asn Asn Phe Leu Glu Lys Glu Lys Ala Ile Leu 
            100                 105                 110         


Glu Ile Glu Ile Tyr Gln Gln Ser Glu Glu Leu Arg Lys Lys Glu Asn 
        115                 120                 125             


Ile Thr Lys Lys Asp Ile Ile Asp Lys Val Ile Glu Asp Lys Ile Thr 
    130                 135                 140                 


Glu Asn Ser Asn Glu Ile Lys Met Gln Ile Lys Leu Glu Lys Asn Asn 
145                 150                 155                 160 


Phe Glu Glu Ile Arg Ile Tyr Ile Asn Lys Glu Leu Gly Gln Tyr Asn 
                165                 170                 175     


Ile Lys Leu Lys Asn Ile Asp Asn Asp Glu Leu Asn Leu Lys Arg Glu 
            180                 185                 190         


Thr Tyr Glu Ile Leu Lys Ser Ile Asn Ala Asn Leu Tyr Ile Ile Thr 
        195                 200                 205             


Lys Asn Ala Ile Ser Asn Ala Asn Phe Glu Lys Arg Asn Tyr Glu Ile 
    210                 215                 220                 


Phe Leu Lys Lys Ser Met Arg Lys Tyr Leu Arg Glu Asn Ile Asn Lys 
225                 230                 235                 240 


Lys Leu Arg Asn Thr Phe Leu Glu Ser Leu Ser Lys Ser Leu Lys Lys 
                245                 250                 255     


Ile Gln Asn Asn Ile Arg Glu Asn Glu Glu Ile Ile Asn Phe Ile Lys 
            260                 265                 270         


Tyr Tyr Ser Ser Ile Asn Gly Asn Lys Thr Val Ser Glu Asn Lys Lys 
        275                 280                 285             


Thr Phe Leu Glu Lys Ile Leu Asn Thr Glu Val Ser Ile Ser Glu Asn 
    290                 295                 300                 


Asp Ile Ile Asp Phe Ile Ile Gly Glu Leu Lys Phe Tyr Gly Ile Ile 
305                 310                 315                 320 


Lys Arg Ile Glu Glu Leu Gln Glu Lys Thr Ile Asp Arg Thr Glu Glu 
                325                 330                 335     


Asp Ile Lys Asn Thr Tyr Ile Asn Thr Tyr Val Ser Leu Asp Lys His 
            340                 345                 350         


Glu Lys Phe Lys Ile Asp Arg Glu Asn Lys Lys Asp Lys Val Val Lys 
        355                 360                 365             


Leu Phe Val Lys Asp Ile His Asn Asn Thr Met Glu Glu Lys Ile Asn 
    370                 375                 380                 


Asp Ile Leu Ser Lys Phe Lys Ile Lys Glu Leu Thr Lys Lys Leu Glu 
385                 390                 395                 400 


Lys Asn Thr Glu Asn Lys Asn Phe Asp Thr Glu Ile Phe Gly Ile Phe 
                405                 410                 415     


Lys Lys His Tyr Lys Val Asn Phe Asp Ser Lys Lys Phe Ser Asn Lys 
            420                 425                 430         


Ser Asp Glu Glu Lys Glu Leu Tyr Lys Ile Ile Tyr Arg Tyr Leu Lys 
        435                 440                 445             


Gly Arg Ile Glu Lys Ile Leu Ile Asn Glu Glu Lys Val Arg Leu Lys 
    450                 455                 460                 


Lys Met Glu Lys Ile Glu Ile Glu Lys Ile Leu Asn Glu Ser Ile Leu 
465                 470                 475                 480 


Ser Glu Lys Ile Leu Lys Arg Val Lys Gln Tyr Thr Leu Glu His Ile 
                485                 490                 495     


Met Tyr Leu Gly Lys Leu Val His Asn Asn Ile Asp Met Thr Thr Val 
            500                 505                 510         


Asn Thr Asn Asp Phe Ser Lys Leu His Ala Lys Glu Glu Leu Asp Leu 
        515                 520                 525             


Glu Leu Ile Thr Phe Phe Ala Ser Thr Asn Met Glu Leu Asn Lys Ile 
    530                 535                 540                 


Phe Ser Arg Glu Asn Ile Asn Asn Asp Glu Asn Ile Asp Phe Phe Gly 
545                 550                 555                 560 


Gly Asp Arg Glu Lys Asn Tyr Val Leu Asp Lys Lys Asn Leu Asn Ser 
                565                 570                 575     


Lys Ile Lys Ile Ile Arg Asp Leu Asp Phe Ile Asp Asn Lys Asn Asn 
            580                 585                 590         


Ile Thr Asn Asp Phe Ile Asn Lys Phe Thr Lys Ile Gly Thr Asn Glu 
        595                 600                 605             


Arg Asn Arg Ile Leu His Ala Ser Gly Lys Lys Arg Asp Ser Gln Gly 
    610                 615                 620                 


Thr Gln Asp Asp Tyr Asn Lys Val Ile Asn Ile Ile Gln Asn Leu Lys 
625                 630                 635                 640 


Ile Ser Asp Glu Glu Val Ser Lys Val Leu Asn Leu Asp Val Val Phe 
                645                 650                 655     


Lys Asp Lys Lys Asn Ile Ile Thr Glu Ile Asn Asp Ile Lys Ile Ser 
            660                 665                 670         


Glu Lys Asn Ser Asn Asp Ile Lys Tyr Leu Pro Ser Phe Ser Lys Val 
        675                 680                 685             


Leu Pro Glu Ile Leu Asn Leu Tyr Arg Asn Asn Pro Lys Asn Glu Pro 
    690                 695                 700                 


Phe Asp Thr Ile Glu Thr Glu Lys Ile Val Leu Asn Ala Leu Ile Tyr 
705                 710                 715                 720 


Val Asn Lys Glu Leu Tyr Lys Lys Leu Ile Leu Glu Asp Asp Leu Gln 
                725                 730                 735     


Glu Asn Arg Ser Lys Asn Ile Phe Leu Gln Glu Leu Lys Lys Thr Leu 
            740                 745                 750         


Gly Asn Ile Asp Glu Thr Asp Glu Asn Ile Ile Glu Asn Tyr Tyr Lys 
        755                 760                 765             


Asn Ala Gln Ile Ser Ala Ser Lys Gly Asn Asn Lys Ala Ile Lys Lys 
    770                 775                 780                 


Tyr Gln Lys Lys Val Ile Glu Tyr Tyr Ile Gly Tyr Leu Arg Lys Asn 
785                 790                 795                 800 


Tyr Glu Glu Leu Phe Asp Phe Ser Asp Phe Lys Met Asn Ile Gln Glu 
                805                 810                 815     


Ile Lys Lys Gln Ile Lys Asp Ile Asn Asp Asn Lys Thr Tyr Glu Arg 
            820                 825                 830         


Ile Thr Ile Lys Thr Ser Asp Lys Ser Ile Val Ile Asn Asp Asp Phe 
        835                 840                 845             


Glu Tyr Ile Ile Ser Ile Phe Ala Leu Leu Asn Ser Asn Thr Val Ile 
    850                 855                 860                 


Asn Lys Ile Arg Asn Arg Phe Phe Ala Thr Ser Val Trp Leu Asp Thr 
865                 870                 875                 880 


Ser Glu Tyr Gln Asn Ile Ile Asn Ile Leu Asp Glu Ile Met Gln Leu 
                885                 890                 895     


Asn Thr Leu Arg Asn Glu Cys Ile Thr Glu Asn Trp Asn Leu Asn Leu 
            900                 905                 910         


Glu Glu Phe Ile Gln Lys Met Lys Glu Ile Glu Lys Asp Phe Asp Asp 
        915                 920                 925             


Phe Lys Ile Gln Thr Lys Lys Asp Ile Phe Asn Gly Asn Tyr Glu Ser 
    930                 935                 940                 


Ile Lys Asn Asn Val Leu Ser Lys Phe Ile Gly Phe Ser Asp Val Gln 
945                 950                 955                 960 


Lys Ile Leu Glu Glu Lys Leu Asn Asn Leu Ile Asp Phe Glu Asn Asp 
                965                 970                 975     


Asn Glu Ile Lys Lys Ser Leu Asn Leu Asp Ser Leu Asn Pro Asp Glu 
            980                 985                 990         


Arg Arg Asn Leu Met Pro Asn Ile  Asn Pro Lys Lys Gly  Gly Ile Asp 
        995                 1000                 1005             


Leu Ile  Lys Glu Ile Asp Lys  Leu Ile Val Ile Lys  Lys Asn Asn 
    1010                 1015                 1020             


Ile Glu  Lys Asn Ile Leu Leu  Lys Ile Ile Phe Asn  Ser Asp Phe 
    1025                 1030                 1035             


Leu Glu  Lys Tyr Lys Lys Glu  Ile Asp Asn Leu Leu  Glu Asp Thr 
    1040                 1045                 1050             


Glu Thr  Glu Asn Lys Asn Lys  Phe Glu Lys Ile Tyr  Tyr Pro Glu 
    1055                 1060                 1065             


Glu His  Lys Asn Glu Leu Tyr  Ile Tyr Lys Lys Asn  Leu Phe Leu 
    1070                 1075                 1080             


Asn Ile  Gly Asn Pro Asn Phe  Asp Lys Ile Tyr Gly  Leu Ile Ser 
    1085                 1090                 1095             


Asn Asp  Ile Lys Met Ala Asp  Ala Lys Phe Leu Phe  Asp Ser Asp 
    1100                 1105                 1110             


Ser Lys  Asp Ile Arg Asn Asn  Glu Ile Ser Lys Ile  Asp Gly Ile 
    1115                 1120                 1125             


Leu Lys  Asn Leu Asn Asp Lys  Leu Asn Gly Tyr Ser  Lys Glu Tyr 
    1130                 1135                 1140             


Lys Glu  Lys Tyr Val Lys Lys  Leu Lys Glu Ser Asn  Asp Phe Phe 
    1145                 1150                 1155             


Ala Lys  Asn Ile Gln Asn Glu  Asn Tyr Ser Ser Phe  Glu Glu Phe 
    1160                 1165                 1170             


Glu Lys  Asn Tyr Asn Lys Ile  Ser Glu Tyr Lys Lys  Ile Arg Asp 
    1175                 1180                 1185             


Leu Val  Glu Phe Asn Tyr Leu  Asn Lys Ile Glu Ser  Tyr Leu Ile 
    1190                 1195                 1200             


Asp Ile  Asn Trp Lys Leu Ala  Ile Gln Met Ala Arg  Phe Glu Arg 
    1205                 1210                 1215             


Asp Met  His Tyr Ile Val Asn  Gly Leu Asp Tyr Leu  Tyr Ile Ile 
    1220                 1225                 1230             


Arg Leu  Glu Lys Asp Arg Asn  Gln Asp Arg Ser Ser  Pro Tyr Pro 
    1235                 1240                 1245             


Lys Tyr  Lys Asn Gly Val Leu  Asp Tyr Thr Lys Ser  Tyr Tyr Asn 
    1250                 1255                 1260             


Phe Lys  Asp Tyr Gln Glu Phe  Met Asp Ile Cys Ser  Lys Phe Gly 
    1265                 1270                 1275             


Ile Asp  Leu Ser Glu Asn Ser  Glu Ile Asn Lys Pro  Glu Ser Glu 
    1280                 1285                 1290             


Ser Ile  Arg Asn Tyr Ile Ser  His Phe Tyr Ile Val  Arg Asn Pro 
    1295                 1300                 1305             


Phe Val  Asp Tyr Ser Ile Ala  Glu Gln Ile Asp Arg  Val Ser Asn 
    1310                 1315                 1320             


Leu Leu  Ser Tyr Ser Thr Arg  Tyr Asn Asn Ser Thr  Tyr Ala Ser 
    1325                 1330                 1335             


Val Phe  Glu Val Phe Lys Lys  Asp Val Asn Leu Asp  Tyr Asp Glu 
    1340                 1345                 1350             


Leu Lys  Lys Lys Phe Lys Leu  Ile Gly Asn Asn Asp  Ile Leu Glu 
    1355                 1360                 1365             


Lys Leu  Met Lys Ser Lys Lys  Val Ser Val Leu Glu  Leu Glu Ser 
    1370                 1375                 1380             


Tyr Asn  Ser Asp Tyr Val Lys  Asn Leu Ile Ile Lys  Leu Leu Thr 
    1385                 1390                 1395             


Lys Ile  Glu Lys Thr Asn Asp  Thr Leu 
    1400                 1405         


<210>  563
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  563

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Leu Tyr Gln Ile Val  Ser Ala Phe Asn Phe  Gly Ser Lys 
    1205                 1210                 1215             


Leu Leu  Tyr Ile Ser Glu Asp  Gly Arg Trp Lys Met  Ala Gly Gly 
    1220                 1225                 1230             


Ala Phe  Pro Gly Lys Tyr Gly  Arg Phe Glu Asn Asp  Tyr Asn His 
    1235                 1240                 1245             


Arg Thr  Ser Leu Ser Lys Val  Ile Arg Leu Phe Glu  Asn Glu Ser 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ile Ile Tyr  Trp Arg Asp Tyr Val  Asp His Met 
    1265                 1270                 1275             


Lys Tyr  Tyr Val Asn Gln Asn  Gln Ser Ile Met Glu  Ile Tyr Ser 
    1280                 1285                 1290             


Ala Phe  Tyr Ser Lys Val Leu  Gly Tyr Ser Ala Lys  Leu Arg Lys 
    1295                 1300                 1305             


Ser Val  Val Phe Asn Leu Gln  Ala Ala Leu Glu Lys  His His Ile 
    1310                 1315                 1320             


Asn Pro  Glu Cys Ile Trp Met  Thr Ser Asp Gly Lys  Cys Ala Asp 
    1325                 1330                 1335             


Ile Lys  Leu Met Lys Asn Leu  Glu Ser Gln Lys Phe  Thr Tyr Lys 
    1340                 1345                 1350             


Leu Ala  Lys Arg Glu Gly Glu  Lys Thr Glu Arg Lys  Ile Cys Met 
    1355                 1360                 1365             


Asn Ala  Leu Asn Glu Asn Phe  Leu Lys Thr Ile Arg  Thr Ser Leu 
    1370                 1375                 1380             


Glu Tyr  Lys Lys 
    1385         


<210>  564
<211>  1427
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  564

Met Lys Leu Ser Lys Glu Asn His Ile Arg Ser Ala Val Val Ile Ser 
1               5                   10                  15      


Gly Lys Glu Gly Asn Ile Ser Gly Thr Leu Tyr Lys Ile Pro Gly Glu 
            20                  25                  30          


Gly Thr Val Asp Leu Lys Lys Arg Met Leu Glu Arg Asp Lys Ala Val 
        35                  40                  45              


Lys Ser Leu Tyr Asn Ile Phe Asn Gln Ile His Leu Gly Asn Glu Pro 
    50                  55                  60                  


Lys Glu Trp Lys Glu Asn Arg Asn Leu Ser Thr Glu Glu Asn Thr Arg 
65                  70                  75                  80  


Arg Met His Gln Lys Glu Val Lys Ile Gln Asn Tyr Lys Met Lys Lys 
                85                  90                  95      


Val Cys Ser Arg Tyr Val Asn Thr Ile Ser Arg Thr Ile Asn Glu Leu 
            100                 105                 110         


Leu Phe Phe Tyr Lys Thr Thr Lys Thr Thr Gln Asn Asn Lys Val Lys 
        115                 120                 125             


Tyr Asp Lys Leu Lys Met Met His Lys Asn Glu Asp Ile Ile Ser Lys 
    130                 135                 140                 


Met Lys Asn Glu Asn Ile Leu Gln Gln Phe Lys Val Glu Gly Lys Asn 
145                 150                 155                 160 


Gly Lys Leu Glu Lys Gly Lys Leu Glu Asp Phe Val Thr Leu Ala Leu 
                165                 170                 175     


Arg Ser Ser Leu Val Val Ser Arg Tyr Lys Gly Lys Asp Phe Asp Ser 
            180                 185                 190         


Val Ala Ala Val Ala Val Phe Leu Glu Asn Ile Gly Asn Asn Asn Ile 
        195                 200                 205             


Ser His Glu Asp Glu Arg Thr Ile Asn Ile Leu Leu Asp Leu Ile Arg 
    210                 215                 220                 


Glu Asp Phe Thr Lys Leu Asn Pro Asn Ile Asp Asn Thr Met Gly Ala 
225                 230                 235                 240 


Arg Leu Ile Arg Ser Val Thr Asn Gln Asn Met Leu Val Gln Pro Gln 
                245                 250                 255     


Asn Asp Arg Phe Ser Phe Pro Cys Val His Asp Ser Gly Lys Ser Lys 
            260                 265                 270         


Val Ser Asn Lys Asn Val Glu Lys Ser Gly Leu Asp Asn Phe Leu Leu 
        275                 280                 285             


Asp Tyr Ala Asn Leu Asp Lys Asp Ile Arg Glu Asn Tyr Leu Arg Lys 
    290                 295                 300                 


Ile Arg Arg Ile Ile Asp Ile Tyr Phe Ser Ala Pro Ile Thr Tyr Gln 
305                 310                 315                 320 


Lys Asp Met Asp Val Ala Leu Ser Glu Val Val Val Lys Asp Lys Phe 
                325                 330                 335     


Asp Val Trp Lys Lys His Asn Glu Trp Lys Lys Asp Asn Asn Thr Phe 
            340                 345                 350         


Val Lys Val Pro Glu Val Leu Ile Lys Ala Glu Thr Asp His Glu Lys 
        355                 360                 365             


Leu Asp Thr Val Ile Glu Lys Gln Ala Arg Lys Glu Leu Ala Asp Arg 
    370                 375                 380                 


Val Arg Glu Gln Asn Met Thr Cys Tyr Arg Tyr Thr Gln Ala Val Val 
385                 390                 395                 400 


Lys Lys Tyr Asn Ala Lys Glu Ala Leu Phe Phe Glu Asn Asp Asp Ile 
                405                 410                 415     


Asn Gln Tyr Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu 
            420                 425                 430         


Lys Asn Cys Lys Ile Gly Thr Leu Phe Lys Leu His Asn Gly Tyr Leu 
        435                 440                 445             


Thr Glu Lys Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr 
    450                 455                 460                 


Ile Ala Leu Gly Lys Val Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp 
465                 470                 475                 480 


Asn Gly Asn Lys Val Lys Leu Leu Gly Asp Ile Ser Glu Lys Ile Arg 
                485                 490                 495     


Ser Gly Ile Thr Ser Phe Asp Tyr Glu Met Leu Lys Ala Gln Glu Thr 
            500                 505                 510         


Leu Gln Arg Glu Leu Ala Val Asn Val Ala Phe Ser Ala Asn Asn Leu 
        515                 520                 525             


Ala Arg Ala Val Cys Asn Met Ser Asp Leu Gly Asp Lys Asn Ser Asp 
    530                 535                 540                 


Phe Leu Leu Trp Gln Pro Asn Asp Ile Asn Asn Lys Met Lys Lys Ser 
545                 550                 555                 560 


Thr Gly Asn Asp Glu Asp Asn Glu Lys Asn Lys Lys Ala Val Cys Ala 
                565                 570                 575     


Val Leu Gln Phe Phe Gly Gly Lys Ser Leu Trp Asn Asp Val Asp Phe 
            580                 585                 590         


Glu Lys Ala Tyr Lys Asn Ala Gly Lys His Gly Tyr Gly Val Tyr Phe 
        595                 600                 605             


Ile Asn Asp Leu Arg Lys Ala Ile Phe Ala Ala Arg Asn Glu Ser Phe 
    610                 615                 620                 


His Phe Lys Thr Ala Ser Val Asn Asn Glu Lys Trp Asn Val Glu Phe 
625                 630                 635                 640 


Leu Gly Arg Met Phe Glu Lys Glu Thr Glu Phe Cys Leu Asp Ile Glu 
                645                 650                 655     


Lys Asp Lys Phe Tyr Ser Asn Asn Leu Pro Met Phe Tyr Lys Ser Ser 
            660                 665                 670         


Asn Leu Glu Lys Met Leu Asn His Phe Tyr Ser Lys Asn Ile Ser Arg 
        675                 680                 685             


Ala Ala Gln Val Pro Ser Tyr Asn Thr Val Phe Val Arg Lys Thr Phe 
    690                 695                 700                 


Pro Glu Tyr Val Asn Asn Val Leu Lys Tyr Lys Lys Pro Gly Thr Asp 
705                 710                 715                 720 


Asp Glu Ile Leu Asp Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu Leu Lys 
                725                 730                 735     


Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Lys Asp Ala Phe Lys Tyr 
            740                 745                 750         


Phe Glu Asn Ala Val Tyr Asn Leu Asn Ser Lys Asn Ile Asn His Asp 
        755                 760                 765             


Ser Ser Gly Gln Lys Leu Ser Arg Asp Glu Met Lys Arg Lys Lys Ala 
    770                 775                 780                 


Ala Glu Ser Phe Gln Arg Arg Phe Val Glu Ile Lys Arg Val Ser Asp 
785                 790                 795                 800 


Ser Ser Ile Ser Cys Val Cys Gln Val Phe Met Thr Asp Tyr Asn Gln 
                805                 810                 815     


Gln Asn Asn Gln Asn Lys Lys Val Arg Ser Ser Asn Asp Ser Leu Leu 
            820                 825                 830         


Asp Lys Pro Ile Tyr Gln His Phe Lys Met Leu Leu Lys Glu Thr Ile 
        835                 840                 845             


Lys Ser Ala Phe Ala Ala Tyr Leu Lys Asp Asn Asn Asn Lys Asp Leu 
    850                 855                 860                 


Phe Gly Phe Ile Gly Glu Pro Leu Lys Ile Asn Lys Asn Asp Asp Val 
865                 870                 875                 880 


Lys Val Ile Lys Lys Glu Glu Phe Leu Pro Asp Trp Lys Ser Glu Lys 
                885                 890                 895     


Tyr Ser Leu Leu Ile Glu Lys Val Lys Lys Ser Pro Lys Leu Gln Met 
            900                 905                 910         


Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met 
        915                 920                 925             


Ala Gly Ser Met Arg Ser Tyr Leu Gln Tyr Val Ser Asp Ile Asn Arg 
    930                 935                 940                 


Arg Ala Asn Val Val Gly Asn Lys Leu His Val Glu Val Leu Asp Lys 
945                 950                 955                 960 


Asp Thr Val Lys Asp Trp Ile Gln Val Ile Glu Val Cys Leu Leu Leu 
                965                 970                 975     


Ala Ser Arg Thr Ser Asn Gln Phe Asp Asp Tyr Phe Asn Asp Gly Asp 
            980                 985                 990         


Asp Tyr Ala Gly Tyr Leu Lys Ser  Tyr Val Asp Phe Ser  Asp Glu Asn 
        995                 1000                 1005             


Met Pro  Ser Ala Tyr Ser Ala  Leu Val Tyr Phe Ser  Asp Gln Gly 
    1010                 1015                 1020             


Lys Ile  Asp Leu Tyr Val Asp  Pro Lys Asn Pro Lys  Ile Asn Arg 
    1025                 1030                 1035             


Asn Ile  Val Gln Ser Lys Leu  Phe Ala Ala Asp His  Ile Leu Gly 
    1040                 1045                 1050             


Asn Gly  Arg Ile Val Gln Pro  Val Ser Lys Asp Asp  Ile Val Glu 
    1055                 1060                 1065             


Phe Tyr  Asn Leu Lys Ala Lys  Ile Ala Asp Ser Lys  Ile Lys Gly 
    1070                 1075                 1080             


Glu Asn  Ile Ser Glu Lys Glu  Gln Arg Asn Ile Ile  Arg Tyr Gln 
    1085                 1090                 1095             


Arg Leu  Lys Asn Lys Val Glu  Leu Arg Asp Ile Val  Glu Tyr Gly 
    1100                 1105                 1110             


Glu Ile  Ile Asn Glu Leu Leu  Gly Gln Leu Ile Asn  Trp Ser Phe 
    1115                 1120                 1125             


Met Arg  Glu Arg Asp Leu Leu  Tyr Phe Gln Leu Gly  Phe His Tyr 
    1130                 1135                 1140             


Asn Cys  Leu Arg Asn Asn Ser  Glu Lys Pro Glu Glu  Tyr Lys Arg 
    1145                 1150                 1155             


Ile Glu  Ala Asp Asp Ile Ser  Ile Asn Asp Ala Val  Leu Tyr Gln 
    1160                 1165                 1170             


Ile Ile  Gly Met Tyr Val Asn  Gly Ile Pro Val Tyr  Thr Ser Asp 
    1175                 1180                 1185             


Asn Asn  Lys Leu Lys Gly Lys  Cys Val Asn Gly Gly  Ala Gly Gly 
    1190                 1195                 1200             


Lys Ile  Ala Ala Val Cys Glu  Tyr Ser Glu Tyr Leu  Gly Phe Lys 
    1205                 1210                 1215             


Lys Ala  Thr Leu Tyr Glu Ser  Gly Leu Glu Val Phe  Glu Val Leu 
    1220                 1225                 1230             


Ala Glu  His Asp Asp Ile Ile  Asn Leu Arg Asn Gly  Ile Asp His 
    1235                 1240                 1245             


Phe Lys  Tyr Tyr Leu Gly Asp  Tyr Arg Ser Met Leu  Ser Ile Tyr 
    1250                 1255                 1260             


Ser Glu  Val Phe Asp Arg Phe  Phe Thr Tyr Asp Met  Lys Tyr Gln 
    1265                 1270                 1275             


Lys Asn  Val Leu Asn Leu Leu  Gln Asn Ile Leu Leu  Arg His Asn 
    1280                 1285                 1290             


Val Ile  Val Glu Pro Val Leu  Glu Ser Gly Val Lys  Thr Ile Gly 
    1295                 1300                 1305             


Glu Gln  Thr Lys Pro Gly Ala  Lys Leu Ser Val Arg  Ser Ile Lys 
    1310                 1315                 1320             


Ser Asp  Thr Phe Glu Tyr Lys  Val Lys Gly Gly Thr  Leu Ile Thr 
    1325                 1330                 1335             


Asn Ala  Lys Asp Lys Arg Tyr  Leu Glu Thr Ile Arg  Lys Ile Leu 
    1340                 1345                 1350             


Tyr Tyr  Ala Asp Ala Glu Asp  Ala Asp Ser Lys Lys  Pro Val Ile 
    1355                 1360                 1365             


Val Thr  Asn Ala Asp Lys Tyr  Glu Lys Asn Lys Glu  Ser Glu Asp 
    1370                 1375                 1380             


Glu Asp  Lys Gln Lys Gly Lys  Glu Asn Arg Gly Lys  Lys Asn Thr 
    1385                 1390                 1395             


Glu Thr  Arg Ser Asp Ala Glu  Lys Asn Asn Asn Glu  Arg Leu Ser 
    1400                 1405                 1410             


Tyr Asn  Pro Phe Ala Asn Phe  Asp Phe Lys Leu Pro  Asn Lys 
    1415                 1420                 1425         


<210>  565
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  565

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Leu Tyr Gln Ile Val  Ser Ala Phe Asn Phe  Gly Ser Lys 
    1205                 1210                 1215             


Leu Leu  Tyr Ile Ser Glu Asp  Gly Arg Trp Lys Met  Ala Gly Gly 
    1220                 1225                 1230             


Ala Phe  Pro Gly Lys Tyr Gly  Arg Phe Glu Asn Asp  Tyr Asn His 
    1235                 1240                 1245             


Arg Thr  Ser Leu Ser Lys Val  Ile Arg Leu Phe Glu  Asn Glu Ser 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ile Ile Tyr  Trp Arg Asp Tyr Val  Asp His Met 
    1265                 1270                 1275             


Lys Tyr  Tyr Val Asn Gln Asn  Gln Ser Ile Met Glu  Ile Tyr Ser 
    1280                 1285                 1290             


Ala Phe  Tyr Ser Lys Val Leu  Gly Tyr Ser Ala Lys  Leu Arg Lys 
    1295                 1300                 1305             


Ser Val  Val Phe Asn Leu Gln  Ala Ala Leu Glu Lys  His His Ile 
    1310                 1315                 1320             


Asn Pro  Glu Cys Ile Trp Met  Thr Ser Asp Gly Lys  Cys Ala Asp 
    1325                 1330                 1335             


Ile Lys  Leu Met Lys Asn Leu  Glu Ser Gln Lys Phe  Thr Tyr Lys 
    1340                 1345                 1350             


Leu Ala  Lys Arg Glu Gly Glu  Lys Thr Glu Arg Lys  Ile Cys Met 
    1355                 1360                 1365             


Asn Ala  Leu Asn Glu Asn Phe  Leu Lys Thr Ile Arg  Thr Ser Leu 
    1370                 1375                 1380             


Glu Tyr  Lys Lys 
    1385         


<210>  566
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  566

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Leu Tyr Gln Ile Val  Ser Ala Phe Asn Phe  Gly Ser Lys 
    1205                 1210                 1215             


Leu Leu  Tyr Ile Ser Glu Asp  Gly Arg Trp Lys Met  Ala Gly Gly 
    1220                 1225                 1230             


Ala Phe  Pro Gly Lys Tyr Gly  Arg Phe Glu Asn Asp  Tyr Asn His 
    1235                 1240                 1245             


Arg Thr  Ser Leu Ser Lys Val  Ile Arg Leu Phe Glu  Asn Glu Ser 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ile Ile Tyr  Trp Arg Asp Tyr Val  Asp His Met 
    1265                 1270                 1275             


Lys Tyr  Tyr Val Asn Gln Asn  Gln Ser Ile Met Glu  Ile Tyr Ser 
    1280                 1285                 1290             


Ala Phe  Tyr Ser Lys Val Leu  Gly Tyr Ser Ala Lys  Leu Arg Lys 
    1295                 1300                 1305             


Ser Val  Val Phe Asn Leu Gln  Ala Ala Leu Glu Lys  His His Ile 
    1310                 1315                 1320             


Asn Pro  Glu Cys Ile Trp Met  Thr Ser Asp Gly Lys  Cys Ala Asp 
    1325                 1330                 1335             


Ile Lys  Leu Met Lys Asn Leu  Glu Ser Gln Lys Phe  Thr Tyr Lys 
    1340                 1345                 1350             


Leu Ala  Lys Arg Glu Gly Glu  Lys Thr Glu Arg Lys  Ile Cys Met 
    1355                 1360                 1365             


Asn Ala  Leu Asn Glu Asn Phe  Leu Lys Thr Ile Arg  Thr Ser Leu 
    1370                 1375                 1380             


Glu Tyr  Lys Lys 
    1385         


<210>  567
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  567

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  568
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  568

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Leu Tyr Gln Ile Val  Ser Ala Phe Asn Phe  Gly Ser Lys 
    1205                 1210                 1215             


Leu Leu  Tyr Ile Ser Glu Asp  Gly Arg Trp Lys Met  Ala Gly Gly 
    1220                 1225                 1230             


Ala Phe  Pro Gly Lys Tyr Gly  Arg Phe Glu Asn Asp  Tyr Asn His 
    1235                 1240                 1245             


Arg Thr  Ser Leu Ser Lys Val  Ile Arg Leu Phe Glu  Asn Glu Ser 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ile Ile Tyr  Trp Arg Asp Tyr Val  Asp His Met 
    1265                 1270                 1275             


Lys Tyr  Tyr Val Asn Gln Asn  Gln Ser Ile Met Glu  Ile Tyr Ser 
    1280                 1285                 1290             


Ala Phe  Tyr Ser Lys Val Leu  Gly Tyr Ser Ala Lys  Leu Arg Lys 
    1295                 1300                 1305             


Ser Val  Val Phe Asn Leu Gln  Ala Ala Leu Glu Lys  His His Ile 
    1310                 1315                 1320             


Asn Pro  Glu Cys Ile Trp Met  Thr Ser Asp Gly Lys  Cys Ala Asp 
    1325                 1330                 1335             


Ile Lys  Leu Met Lys Asn Leu  Glu Ser Gln Lys Phe  Thr Tyr Lys 
    1340                 1345                 1350             


Leu Ala  Lys Arg Glu Gly Glu  Lys Thr Glu Arg Lys  Ile Cys Met 
    1355                 1360                 1365             


Asn Ala  Leu Asn Glu Asn Phe  Leu Lys Thr Ile Arg  Thr Ser Leu 
    1370                 1375                 1380             


Glu Tyr  Lys Lys 
    1385         


<210>  569
<211>  1287
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  569

Met Arg Ile Gly Lys Val Gln Gly Arg Thr Phe Thr Gly Phe Asp Asn 
1               5                   10                  15      


Ala Arg Gly Lys Thr Leu Arg Arg Arg Leu Leu Thr Arg Pro Asp Asn 
            20                  25                  30          


Glu Ala Arg Ser Leu Ser Glu His Leu Ala His Asp Pro Lys Ala Leu 
        35                  40                  45              


Ile Gly Gln Ala Ile Ser Arg Ile Asp Thr Ile Tyr Gln Lys Pro Lys 
    50                  55                  60                  


Thr Gly Lys Pro Thr Pro Glu Gln Phe Gly His Arg Asp Thr Leu Gly 
65                  70                  75                  80  


Trp Ala Tyr Trp Lys Leu Leu Val Ala Ser Tyr Pro Glu Val Glu Gly 
                85                  90                  95      


His Arg Asp Leu Phe Val Arg Arg Leu His Pro Tyr Gly Asp Thr Pro 
            100                 105                 110         


Pro Lys Ser His Gly Gln Lys Glu Gly Glu His Gln Lys Gly Gly Lys 
        115                 120                 125             


Pro Gln Leu Glu Gly Arg Trp His Gly Val Met Ala Gln His Gly Lys 
    130                 135                 140                 


Asn Pro Asp Gln Ile Ala Ala Arg Leu Phe Asp His Leu His Asn Ser 
145                 150                 155                 160 


Glu Leu Arg Phe Gly Gly Thr Ala Ser Gly Glu Pro Arg Thr Arg Pro 
                165                 170                 175     


Gly Lys Glu Ala Thr Pro Thr Gly Leu Ile Gly Ala Arg Ala Lys Thr 
            180                 185                 190         


Ile Glu His Ser Val Leu Pro Arg Asp Ala Lys Arg Phe Val Ala Glu 
        195                 200                 205             


Trp Arg Gly Glu Asp Gln Glu Arg Tyr Ala Gly Ala Arg Asp Ile Ala 
    210                 215                 220                 


Ala Ala Ile Ser Ala Gly Leu Asn Asp Lys Asp Gln Lys Ser Gly Ser 
225                 230                 235                 240 


Gly Arg Lys Ser Ala Val Ile Gly Lys Leu Leu Ser Asp His Leu Glu 
                245                 250                 255     


Thr Leu Thr Gly Asn Arg Lys Cys Arg Phe Asp Pro Lys Ser Thr Ala 
            260                 265                 270         


Glu Thr Leu Glu Leu Arg Asp Gly Glu Ser Val Asp Asp Arg Arg Arg 
        275                 280                 285             


Ile Leu Glu Leu His Ala Glu Val Lys Ala Thr Tyr Lys Arg Met Ala 
    290                 295                 300                 


Ala Trp Lys Pro Ala Lys Leu Pro Arg Asn Ser Asp Glu Leu Phe Arg 
305                 310                 315                 320 


Leu Val Arg Gln Gln Ala Asp Asn Arg Ile Leu Asn His Leu Val Arg 
                325                 330                 335     


Val Gly Arg Ile Ser Val Tyr Ser Glu Gln Ser Asp Ala Leu Ser Glu 
            340                 345                 350         


Ser Gln Phe Trp Thr Ser Gly Gly Gln Thr Gln Ile Lys Glu Ser Glu 
        355                 360                 365             


Val Phe Ala Arg Leu Trp Ile Gly Ala Ile Ser Arg Ala Ser Tyr Ser 
    370                 375                 380                 


Met Lys Ala Trp Leu Glu Pro Glu Gly Thr Val Phe Asn Pro Ser Ile 
385                 390                 395                 400 


Asn Asp Phe Asp Val Thr Ser Ser His Asn Thr Asn Arg Ile Leu Glu 
                405                 410                 415     


Asp Ser Gly Arg Leu Ser Asn Ala Met Ala Arg Arg Ala Ile Tyr Phe 
            420                 425                 430         


Gly Glu Thr Pro Glu Phe Asp Ala Leu Gly Glu Glu Asp Gln Arg Val 
        435                 440                 445             


Leu Val Lys Lys Cys Leu Asp Ala Leu Ser Ala Cys Arg Asn Arg Thr 
    450                 455                 460                 


Phe His His Gly Gln Arg Ala Lys Phe Leu Lys Glu Val Arg Lys Gly 
465                 470                 475                 480 


Leu Lys Glu Lys Glu Ala Asp Ser Ala Gly Pro Ala Ala Trp Glu Gly 
                485                 490                 495     


Ile Arg Glu Val Ile Gln Ala Asp Ala Arg Asn Leu Gly Ala Arg Leu 
            500                 505                 510         


Leu Gln Asp Leu Thr Gly Ala Lys Val His Ser Phe Ala Thr Asp Pro 
        515                 520                 525             


Glu Phe Arg His Leu Tyr Glu Ser Val Ala Ala Thr Leu Thr Ala Gly 
    530                 535                 540                 


Gly Glu Leu Glu Ala Ala Leu Pro Arg Leu Lys Asn Val Leu Lys Arg 
545                 550                 555                 560 


Ala Glu Gly Val Arg Cys Tyr Leu Asp Thr Pro Ser Gln Arg Arg Glu 
                565                 570                 575     


Gly Asp Glu Ser Leu Ile Ala Arg Leu Pro Val Ala Pro Val Pro Arg 
            580                 585                 590         


Glu Leu Asp Asp Ala Ala Thr Lys Ala Arg His Ser Ala Leu Leu Arg 
        595                 600                 605             


Leu Tyr Asp Gly Pro Phe Arg Pro Trp Ala Thr Glu Leu Arg Gly Glu 
    610                 615                 620                 


Arg Leu Ser Asp Tyr Ala Ala Arg Ala Lys Arg Leu Ala Thr Arg Leu 
625                 630                 635                 640 


Ala Lys Ser Thr Asn Thr Ala Ser Pro Tyr Pro Asp Ser Val Glu Gly 
                645                 650                 655     


Arg Ser Val Arg Leu Arg Asp Pro Ile Thr Ala Asp Thr Ala Pro Glu 
            660                 665                 670         


Thr Leu Lys Thr Tyr Leu Ser Ala Leu Thr Ala Glu Thr Ala Thr Glu 
        675                 680                 685             


Phe Arg Val Gln Lys Gly Tyr Glu Ser Asp Gly Glu Lys Ala Lys Glu 
    690                 695                 700                 


Gln Ala Glu Phe Ile Glu Asp Phe Arg Arg Asp Met Ile Ala Leu Ala 
705                 710                 715                 720 


Phe Gln Asp Phe Ile Arg Asp His Gly Phe Ala Trp Leu Leu Asp Ile 
                725                 730                 735     


Ala Ser Lys Ala Glu Pro Ser Asn Asp Ala Pro Asn Leu Pro Asp Pro 
            740                 745                 750         


Val Asp Thr Gly Lys Asp Thr Val Phe Glu Asp Trp Gln Ala Leu Leu 
        755                 760                 765             


Tyr Leu Phe Leu His Phe Val Pro Ala Asp Asp Val Ser Gln Leu Leu 
    770                 775                 780                 


His Gln Leu Arg Lys Trp Asp Ala Leu Gln Asp Lys Tyr Glu Leu Ala 
785                 790                 795                 800 


Glu Pro Gly Glu Thr Leu Gly Gln Thr Lys Ala Asp Thr Arg Lys Ile 
                805                 810                 815     


Val Gly Gln Phe Arg Asp Cys Leu Thr Leu Phe Leu Lys Thr Gly Asp 
            820                 825                 830         


Ala Arg Phe Asp Gly Glu Gly Val Glu Leu Pro Leu Ser Asp Phe Gln 
        835                 840                 845             


Glu Leu Phe Glu Ser Pro Ala Thr Phe Lys Glu Leu Phe Leu Ala Glu 
    850                 855                 860                 


Pro Ala Glu Asn Asp Ala Ser Glu Thr Asp Asp Gln Asp Ala Pro Gly 
865                 870                 875                 880 


Glu Lys His Arg Val Thr Arg Thr Arg Arg Gly Leu Arg Gln Ile Leu 
                885                 890                 895     


Arg Tyr Asn His Met Pro Val Leu Arg Asp Leu Phe Leu Ala His Lys 
            900                 905                 910         


Val Thr Asp Ala Glu Val Asp Gly Leu Gln Ala Leu Glu Val Asp Asp 
        915                 920                 925             


Pro Gln Thr Gly Glu Ser Gln Ile Gly Ala Ala Gln Arg Ile Arg Thr 
    930                 935                 940                 


Glu Ile His His His Thr Ser Asn Asp Lys Gln Ile Ser Glu Ala Lys 
945                 950                 955                 960 


Val Glu Glu Tyr Arg Arg Ala Leu Ser Thr Ile Glu Arg His Arg Phe 
                965                 970                 975     


Leu Val Gly Arg Val Tyr Leu Gly Asp His Ile Arg Val His Lys Leu 
            980                 985                 990         


Met Met Asp Val Met Gly Arg Leu  Val Asp Phe Ala Gly  Ala Trp Glu 
        995                 1000                 1005             


Arg Glu  Ala Ala Asp Gly Asp  Arg Lys Gly Phe Ile  Ser Arg Ala 
    1010                 1015                 1020             


Ile Ala  Leu Pro Glu Val Ala  Glu Gly Tyr Ala Ala  Asp Arg Leu 
    1025                 1030                 1035             


Lys Thr  Val Ala Arg Arg Val  Leu Asp Asp Gly Glu  Ala Arg Arg 
    1040                 1045                 1050             


Ile Arg  Asn Asp Leu Gly His  Phe Asn Asp Leu Ala  Pro Thr Ser 
    1055                 1060                 1065             


Gly Pro  Ala Asn Leu Thr Phe  Val Val Asn Arg Ala  Arg Arg Met 
    1070                 1075                 1080             


Met Arg  His Asp Arg Lys Arg  Lys Asn Ala Val Thr  Lys Ser Val 
    1085                 1090                 1095             


Ile Glu  Ile Leu Asn Arg Gln  Gly Leu Gly Ile Glu  Trp Thr Met 
    1100                 1105                 1110             


Arg Asn  His Glu Leu Cys Glu  Ala Lys Leu Trp Gln  Asn Pro Val 
    1115                 1120                 1125             


Lys His  Leu Gly Phe Ala Thr  Leu Glu Gly Arg Gly  Lys Lys Trp 
    1130                 1135                 1140             


Arg Arg  Pro Phe Glu Ala Arg  Tyr Gly Asp Ala Tyr  Met Ala Met 
    1145                 1150                 1155             


Val Ala  Gln Leu Phe Asp Gly  Thr Val Thr Ser Pro  Pro Ala Lys 
    1160                 1165                 1170             


Gly Pro  Pro Gln Ser Gly Lys  Ser Gly Gly Lys Pro  Gly Lys Gly 
    1175                 1180                 1185             


Ala Glu  Gly Gly Ala Lys Glu  Lys Ser Arg Ser Pro  Thr Arg Met 
    1190                 1195                 1200             


Glu Glu  Gly Gly Val Tyr Glu  Gly Arg Val Ala Lys  Ala Lys Ser 
    1205                 1210                 1215             


Asp Lys  Gly Phe Gly Phe Leu  Leu Val Glu Gly Ala  Gln Glu Glu 
    1220                 1225                 1230             


Ile Phe  Leu His Ile Tyr Gly  Ile Ser Gly Asn Arg  Pro Ala Arg 
    1235                 1240                 1245             


Ile Glu  Asn Gly Gln Arg Tyr  Arg Phe Thr Leu Gly  Ile Asp Arg 
    1250                 1255                 1260             


Asp Arg  Glu Arg Arg Lys Glu  Arg Ala Trp Val Ala  Arg Glu Ala 
    1265                 1270                 1275             


Val Arg  Ile Asp Glu Asn Arg  Ser Lys 
    1280                 1285         


<210>  570
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  570

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Thr Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Asp Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Ser Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val His Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Leu Asn 
    1400                 1405                 1410         


<210>  571
<211>  1357
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  571

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Pro Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Lys Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Asp Ile Gln Arg Ile Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Lys Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Thr Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Ile Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Ile Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Gln Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Lys 
                405                 410                 415     


Arg Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Ala Leu Glu Gly Glu Ser 
    450                 455                 460                 


Val Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Glu Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Ala Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Lys Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Lys Asp Asp Glu Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Ser Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Lys Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Ala Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Val Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Glu Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Asp 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Lys Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Val Leu Val Pro Ala  Arg Ser Glu 
    1325                 1330                 1335             


Val Phe  Leu Lys Gln Phe Arg  Lys Ile Leu Glu Tyr  Arg Ile Gln 
    1340                 1345                 1350             


Asp Lys  Thr Gln 
    1355         


<210>  572
<211>  1182
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  572

Met Gly Ser Gly Lys Tyr Arg Ile Thr Lys Ile Ala Arg Lys Trp Asp 
1               5                   10                  15      


Lys Asn Glu Asn Trp Glu Lys Ile Ile Leu Lys Arg Ile Val Asp Asn 
            20                  25                  30          


Lys Lys Ile Lys Tyr Val Asn Glu Asn Asn Asn Lys Asp Val Asp Ile 
        35                  40                  45              


Thr Asp Thr Tyr Tyr Asn Ile Leu Ser Lys Asn Asn Ser Lys Phe Leu 
    50                  55                  60                  


Gly Ser Glu Glu Gln Phe Leu Phe Lys Val Asn Lys Met Asp Arg Asn 
65                  70                  75                  80  


Ile Lys Asn Asp Tyr Val Ile Ile Lys Asp Tyr Asn Glu Glu Glu Phe 
                85                  90                  95      


Glu Lys Phe Asp Lys Lys Ile Phe Phe Ser Arg Lys Ile Lys Val Asn 
            100                 105                 110         


Asn Glu Asp Arg Glu Lys Ile Cys Arg Asn Phe Tyr Glu Asp Glu Arg 
        115                 120                 125             


Glu Ile Met Lys Lys Arg Leu Glu Glu Ala Lys Asn Phe Asn Asn Ile 
    130                 135                 140                 


Ile Phe Asn Ile Cys Asn Lys Ile Phe Lys Leu Glu Tyr Ile Asp Tyr 
145                 150                 155                 160 


Thr Asp Glu Lys Val Tyr Glu Ile Phe Gln Lys Glu Ile Lys Phe Glu 
                165                 170                 175     


Asp Ile Lys Asn Leu Lys Glu Ala Phe Lys Gln Gln Glu Asn Gly Leu 
            180                 185                 190         


Glu Thr Asp Lys Leu Leu Ala Ile Ser Phe Asn Lys Lys Arg Asn Asn 
        195                 200                 205             


Val Leu Leu Glu Phe Ile Gln Gln Ile Thr Lys Gln Glu Phe Lys Asn 
    210                 215                 220                 


Gln Lys Glu Leu Glu Asn Trp Phe Ser His Ser Gly Glu Lys Tyr Cys 
225                 230                 235                 240 


Lys Glu Ile Phe Lys Ile Tyr Ser Asn Met Ser Gln Lys Glu Lys Tyr 
                245                 250                 255     


Ser Lys Leu Leu Gly His Arg Asn Lys Ser Ile Ala Ser Ile Ser Glu 
            260                 265                 270         


Lys Lys Glu Thr Leu Gln Arg Arg Leu Lys Leu Gly Asn Tyr Ser Asn 
        275                 280                 285             


Tyr Asp Leu Lys Lys Tyr Tyr Gln Lys Asn Tyr Lys Glu Lys Ala Ile 
    290                 295                 300                 


Lys Glu Leu Lys Asp Lys Asn Lys Glu Glu Phe Glu Lys Glu Ile Glu 
305                 310                 315                 320 


Gly Leu Ile Lys Lys Asn Tyr Lys Ile Asp Lys Leu Cys Glu Glu Ile 
                325                 330                 335     


Ser Asn Leu Glu Phe Ser Phe Ala Glu Ser Lys Lys Glu Asn Lys Asp 
            340                 345                 350         


Lys Met Ala Glu Ile Ile Val Lys Ile Lys Glu His Tyr Lys Asn Asn 
        355                 360                 365             


Val Asn Val Glu Lys Glu Leu Glu Asn Lys Glu Lys Tyr Ile Leu Ser 
    370                 375                 380                 


Met Ile His Asn Tyr Ile Lys Gly Arg Tyr Arg Lys Cys Leu Glu Leu 
385                 390                 395                 400 


Gln Gln Lys Glu Asn Val Asp Phe Glu Asn Leu Gly Lys Arg Ile Lys 
                405                 410                 415     


Glu Ile Phe Asp Ser Asn Glu Val Thr Glu Lys Leu Lys Lys Ser Ile 
            420                 425                 430         


Ile Asn Lys Val Asn Asn Tyr Lys Ile Phe Glu Thr Lys Phe Gln Asn 
        435                 440                 445             


Pro Asn Ile Glu Ser Ser Asp Asp Leu Glu Ile Leu Lys Ala Glu Glu 
    450                 455                 460                 


Thr Phe Leu Asn Lys Leu Ser Thr Ala Val Ser Lys Val Gly Tyr Thr 
465                 470                 475                 480 


Leu Asn Ile Leu Leu Asp Thr Arg Thr Thr Ser Lys Lys Met Asn Lys 
                485                 490                 495     


Lys Lys Ile Lys Asn Pro Asp Ile Leu Ala Gly Tyr Asn Val Thr Ile 
            500                 505                 510         


Glu Leu Leu Pro Tyr Cys Ser Phe Glu Ile Leu Tyr Ser Val Tyr Pro 
        515                 520                 525             


Glu Ile Lys Lys Asp Ile Glu Leu Leu Lys Gly Met Val Leu Phe Ile 
    530                 535                 540                 


Gln Glu Phe Arg Gln Lys Ile Leu His Pro Ser Gln Leu Leu Gly Ser 
545                 550                 555                 560 


Asn Val Lys Lys Ser Ile Ser Ile Lys Glu Lys Asp Thr Ile Val Lys 
                565                 570                 575     


Ile His Glu Asp Asn Lys Asp Asn Glu Lys Trp Glu Met Tyr Asn Lys 
            580                 585                 590         


Glu Lys Ile Arg Ser Tyr Phe Glu Asp Ile Leu Glu Lys Ile Pro Asp 
        595                 600                 605             


Tyr Phe Ile Glu Lys Tyr Glu Ser Asn Asn Val Phe Asn Ile Tyr Arg 
    610                 615                 620                 


Asp Phe Gly Val Lys Ile Met Glu Val Val Lys Asn Phe Asn Phe Lys 
625                 630                 635                 640 


Glu Asn Asn Ala Ile Asp Tyr Leu Phe Pro Lys Phe His Lys Ile Tyr 
                645                 650                 655     


Lys Arg Met Cys Lys Leu Glu Asn Ile Asp Asp Arg Gln Asn Gly Ala 
            660                 665                 670         


Arg Lys Tyr Leu Leu Gln Thr Ile Tyr Tyr Tyr Tyr Phe Gln Tyr Glu 
        675                 680                 685             


Ile Glu Asn Asp Lys Asn Asn Ile Ser Lys Tyr Leu Asn Leu Tyr Arg 
    690                 695                 700                 


Asn Glu Ile Lys Val Lys Lys Ile Ser Tyr Ser Tyr Ile Thr Asp Asn 
705                 710                 715                 720 


Lys Ala Val Asn Asn Lys Asn Ile Glu Ile Leu Tyr Arg Asn Ile Gln 
                725                 730                 735     


Arg Glu Gly Met Leu Asn Asn Arg Phe Ser Gln Met Asn Lys Glu Trp 
            740                 745                 750         


Ile Glu Phe Ile Val Val Gln Phe Ser Glu Phe Leu Thr Asn Lys Lys 
        755                 760                 765             


Leu Asn Trp Ile Leu Asp Asn Leu Ser Glu Tyr Lys Lys Lys Glu Lys 
    770                 775                 780                 


Leu Asp Glu Asn Asp Lys Asn Arg Leu Leu Lys Ile Leu Lys Gln Lys 
785                 790                 795                 800 


Met Asn Lys Lys Ile Thr Tyr Ser Asn Asp Ser Tyr Ala Phe Ile Ser 
                805                 810                 815     


Leu Ala Gln Phe Leu Asp Leu Lys Glu Ile Ser Asn Leu Ile His Asp 
            820                 825                 830         


Ile Lys Lys Phe Ile Gln Phe Arg Glu Lys Asn Val Ser Lys Tyr Lys 
        835                 840                 845             


Pro Glu Lys Asn Lys Leu Tyr Ile Glu Glu Leu Arg Lys Ile Leu Tyr 
    850                 855                 860                 


Ile Leu Lys Val Met Leu Glu His Lys Glu Arg Val Ile Gln Lys His 
865                 870                 875                 880 


Tyr Leu Glu Ser Tyr Asp Glu Asp Ile Ser Ile Met Tyr Gly Lys Asp 
                885                 890                 895     


Ile Glu Lys Lys Asp Ile Lys Asp Ile Glu Ile Lys Ile Lys Asn Lys 
            900                 905                 910         


Asn Gln Glu Val Ile Asn Gln Pro Leu Tyr Lys Ser Gly Asn Asp Glu 
        915                 920                 925             


Asn Ser Ser Trp Ile Val Leu Tyr Gly Ile Glu Gln Ala Lys Arg Asn 
    930                 935                 940                 


Gly Thr Phe Lys Phe Phe Glu Gly Phe Phe Asn Leu Asn Asp Asp Ile 
945                 950                 955                 960 


Lys Leu Cys Lys Glu Asn Ile Glu Lys Tyr Glu Glu Leu Tyr Asn Glu 
                965                 970                 975     


Lys Glu Glu Asn Gln Arg Lys Val Asp Glu Tyr Ile Ser Ser Glu Glu 
            980                 985                 990         


Asn Asn Asn Ile Asp Glu Val Lys  Glu Ile Lys Glu Ile  Asn Asn Asn 
        995                 1000                 1005             


Lys Gln  Leu Phe Tyr Tyr Tyr  Lys Asn Met Ile Tyr  Gly Asp Gly 
    1010                 1015                 1020             


Leu Lys  Lys Gly Tyr Asp Phe  Ile Asn Asp Ile Tyr  Ser His Tyr 
    1025                 1030                 1035             


Leu Ser  Trp Ala Tyr Arg Val  Glu Arg Asp Cys Lys  Ile Tyr Lys 
    1040                 1045                 1050             


Ile Lys  Glu Tyr Glu Asn Lys  Lys Asn Phe Asn Glu  Tyr Lys Phe 
    1055                 1060                 1065             


Lys Glu  Tyr Lys Ser Ile Lys  Asn Phe Arg Asn Glu  Val Ala His 
    1070                 1075                 1080             


Phe Asn  Tyr Phe Gln Lys Thr  Asp Lys Ser Leu Leu  Asp Leu Leu 
    1085                 1090                 1095             


Asn Asp  Phe Tyr Ser Ile Phe  Asp Tyr Asn Leu Lys  Tyr Gln Arg 
    1100                 1105                 1110             


Asp Val  Gln Lys Val Ile Asn  Asn Ile Phe Glu Lys  Tyr Gln Val 
    1115                 1120                 1125             


Ile Arg  Glu Asp Gly Gly Pro  Val Ile Phe Tyr Cys  Lys Ile Asp 
    1130                 1135                 1140             


Lys Lys  Leu Lys Leu Ser Glu  Asn Ile Ile Pro Lys  Lys His Leu 
    1145                 1150                 1155             


Lys Cys  Ser Lys Ile Lys Leu  Ile His Glu Lys Tyr  Val Glu Phe 
    1160                 1165                 1170             


Phe Arg  Lys Leu Phe Glu Tyr  Lys Lys 
    1175                 1180         


<210>  573
<211>  1386
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  573

Met Gly Asn Leu Phe Gly His Lys Arg Trp Tyr Glu Val Ser Asp Arg 
1               5                   10                  15      


Gly Asp Asn Lys Ile Lys Arg Lys Val Lys Val Lys Arg Asn Tyr Asp 
            20                  25                  30          


Gly Asn Lys Tyr Ile Leu Asn Ile Asn Glu Asn Asn Asn Lys Glu Lys 
        35                  40                  45              


Ile Asp Asp Asn Lys Phe Ile Glu Glu Phe Val Asn Tyr Lys Lys Asn 
    50                  55                  60                  


Asp Asn Val Leu Ile Glu Phe Lys Arg Lys Phe His Ala Gly Asn Ile 
65                  70                  75                  80  


Leu Phe Lys Leu Lys Gly Asn Lys Arg Ser Ile Glu Asp Ser Asn Asp 
                85                  90                  95      


Phe Leu Lys Thr Glu Lys Ile Ile Leu Asp Lys Glu Val Tyr Gly Gln 
            100                 105                 110         


Ser Glu Lys Leu Arg Asn Glu Lys Gly Ile Thr Lys Gln Asp Ile Leu 
        115                 120                 125             


Lys Glu Ile Ile Asp Lys Gly Ile Asp Lys Ser Asn Asp Lys Ile Leu 
    130                 135                 140                 


Val Lys Thr Lys Phe Gly Lys Glu Ile Thr Ile Asn Phe Thr Asp Glu 
145                 150                 155                 160 


Asp Lys Lys Asn Lys Asn Lys Tyr Gln Ile Thr Leu Lys Ile Ile Pro 
                165                 170                 175     


Glu Asn Glu Leu Lys Ile Lys Arg Glu Val Tyr Asn Val Phe Lys Ile 
            180                 185                 190         


Ile Asn Ile Asn Leu Tyr Gln Ile Ile Lys Gly Ile Ile Glu Asn Lys 
        195                 200                 205             


Glu Ile Phe Lys Asn Arg Tyr Tyr Asp Glu Ile Leu Lys Glu Lys Leu 
    210                 215                 220                 


Ser Lys Asn Asn Gln Ile Ile Asn Thr Leu Thr Asn Leu Asn Lys Ile 
225                 230                 235                 240 


Arg Lys Glu Ile Arg Asp Asn Arg Asp Asn Ile Ile Gly Phe Val Lys 
                245                 250                 255     


Phe Tyr Leu Asn Val Ser Gly Asp Lys Lys Lys Ser Glu Asn Lys Lys 
            260                 265                 270         


Met Phe Val Glu Lys Ile Leu Asn Thr Asn Val Asp Leu Thr Val Glu 
        275                 280                 285             


Asp Ile Val Asp Phe Ile Val Lys Glu Leu Lys Phe Trp Asn Ile Thr 
    290                 295                 300                 


Lys Arg Ile Glu Lys Leu Gln Glu Lys Thr Val Asn Arg Ala Asp Glu 
305                 310                 315                 320 


Asp Ile Lys Asn Thr Tyr Ile Asn Thr Tyr Val Leu Leu Asp Lys His 
                325                 330                 335     


Glu Lys Phe Lys Lys Tyr Asn Arg Asn Lys Lys Asp Thr Ile Val Lys 
            340                 345                 350         


Ser Phe Ile Lys Asp Ile Lys Asp Asn Thr Met Lys Gln Lys Ile Asn 
        355                 360                 365             


Gln Ile Leu Arg Lys Phe Lys Ile Glu Glu Leu Ile Glu Lys Leu Arg 
    370                 375                 380                 


Ile Glu Asn Lys Asn Phe Asp Thr Glu Ile Phe Arg Ile Phe Lys Asp 
385                 390                 395                 400 


His Tyr Gln Glu Met Phe Ser Leu Glu Lys Phe Glu Glu Lys Pro Asp 
                405                 410                 415     


Glu Glu Lys Glu Leu Tyr Lys Ile Ile Tyr Arg Tyr Leu Lys Gly Arg 
            420                 425                 430         


Ile Glu Lys Ile Leu Ile Asn Glu Gln Lys Val Arg Leu Lys Lys Met 
        435                 440                 445             


Glu Lys Ile Glu Ile Glu Lys Ile Leu Asn Glu Ser Ile Leu Ser Glu 
    450                 455                 460                 


Lys Val Leu Lys Arg Val Lys Gln Tyr Thr Leu Glu His Val Met Tyr 
465                 470                 475                 480 


Leu Gly Lys Leu Ile His Asn Asp Val Asn Met Thr Thr Val Asn Thr 
                485                 490                 495     


Asp Asp Phe Thr Lys Leu His Ala Lys Glu Glu Leu Asp Leu Glu Leu 
            500                 505                 510         


Ile Thr Phe Phe Ala Ser Thr Asn Met Glu Leu Asn Lys Ile Phe Asn 
        515                 520                 525             


Gly Lys Glu Lys Ile Thr Asp Phe Phe Gly Phe Asn Leu Asn Gly Gln 
    530                 535                 540                 


Lys Ile Thr Leu Lys Glu Lys Val Pro Ser Phe Lys Leu Asn Ile Leu 
545                 550                 555                 560 


Lys Lys Leu Asn Phe Ile Asn Asn Glu Asn Asn Ile Asp Glu Lys Leu 
                565                 570                 575     


Ser His Phe Tyr Ser Phe Gln Lys Glu Gly Tyr Leu Leu Arg Asn Lys 
            580                 585                 590         


Ile Leu His Asn Ser Tyr Gly Asn Ile Gln Glu Thr Ile Asn Leu Lys 
        595                 600                 605             


Gly Glu Tyr Glu Asn Val Glu Asn Leu Ile Lys Glu Leu Lys Val Ser 
    610                 615                 620                 


Asn Glu Glu Ile Ser Lys Ser Leu Asn Leu Asp Ile Ile Phe Glu Gly 
625                 630                 635                 640 


Lys Val Asp Ile Ile Asn Lys Ile Asn Ser Leu Glu Ile Gly Glu Tyr 
                645                 650                 655     


Lys Asp Lys Lys Tyr Leu Pro Ser Phe Ser Lys Ile Val Pro Glu Ile 
            660                 665                 670         


Met Arg Lys Phe Arg Glu Ile Asn Lys Asp Lys Ser Phe Asp Ile Glu 
        675                 680                 685             


Ser Glu Lys Ile Ile Leu Asn Ala Val Gln Tyr Val Asn Lys Ile Leu 
    690                 695                 700                 


Tyr Glu Lys Ile Thr Ser Asn Glu Glu Asn Glu Phe Ile Lys Thr Leu 
705                 710                 715                 720 


Pro Asp Lys Leu Val Lys Lys Asn Asn Asn Lys Glu Asn Lys Asn Ser 
                725                 730                 735     


Leu Ser Ile Glu Glu Tyr Tyr Lys Asn Ala Gln Ile Ser Ser Ser Lys 
            740                 745                 750         


Gly Asp Lys Lys Ala Ile Lys Lys Tyr Gln Asn Lys Val Thr Asn Ala 
        755                 760                 765             


Tyr Ile Glu Tyr Leu Glu Asn Thr Phe Ala Glu Val Ile Asp Phe Ser 
    770                 775                 780                 


Asn Phe Asn Leu Asn Phe Asp Glu Ile Lys Thr Lys Ile Glu Glu Arg 
785                 790                 795                 800 


Lys Tyr Ser Lys Ser Lys Ile Thr Val Asp Ser Ile Ser Thr Asn Ile 
                805                 810                 815     


Asn Ile Thr Asn Asp Ile Glu Tyr Ile Ile Ser Ile Phe Ala Leu Leu 
            820                 825                 830         


Asn Ser Asn Thr Tyr Ile Asn Lys Ile Arg Asn Arg Phe Phe Ala Thr 
        835                 840                 845             


Ser Val Trp Leu Asp Lys Gln Asn Ser Thr Lys Glu Tyr Asp Tyr Glu 
    850                 855                 860                 


Asn Ile Ile Asp Ile Leu Asp Lys Ile Leu Ser Ile Asn Leu Leu Arg 
865                 870                 875                 880 


Glu Asn Asn Ile Ala Asp Ile Leu Asp Leu Lys Asn Thr Ile Ile Glu 
                885                 890                 895     


Ala Lys Ile Val Glu Asn Asn Glu Glu Cys Ile Lys Asn Tyr Ile Phe 
            900                 905                 910         


Glu Asn Asn Glu Glu Glu Leu Lys Lys Arg Leu Phe Cys Glu Glu Leu 
        915                 920                 925             


Val Asn Lys Glu Glu Val Leu Lys Ile Phe Glu Asp Lys Asn Phe Lys 
    930                 935                 940                 


Phe Lys Asn Phe Ile Lys Lys Asn Glu Ile Gly Asn Phe Lys Ile Asn 
945                 950                 955                 960 


Phe Asp Val Leu Ser Asn Leu Glu Cys Asn Ser Glu Val Glu Val Lys 
                965                 970                 975     


Lys Val Ile Gly Gln Asn Ser Lys Lys Leu Glu Ser Phe Ile Gln Asn 
            980                 985                 990         


Thr Ile Asp Glu Tyr Lys Ser Asn  Ile Arg Thr Leu Phe  Ser Ser Glu 
        995                 1000                 1005             


Phe Leu  Glu Lys Tyr Lys Glu  Glu Ile Asp Asn Leu  Val Glu Cys 
    1010                 1015                 1020             


Thr Glu  Ser Lys Asn Glu Asn  Lys Phe Glu Lys Ile  Tyr Tyr Pro 
    1025                 1030                 1035             


Glu Glu  His Lys Asn Glu Leu  Tyr Ile Tyr Lys Lys  Asn Leu Phe 
    1040                 1045                 1050             


Leu Asn  Ile Gly Asn Pro Asn  Phe Asp Lys Ile Tyr  Glu Leu Ile 
    1055                 1060                 1065             


Ser Lys  Asp Ile Lys Asn Ala  Asn Thr Glu Ile Leu  Phe Asn Asp 
    1070                 1075                 1080             


Asp Ile  Arg Asn Asn Lys Ile  Ala Glu Ile Asp Val  Ile Leu Lys 
    1085                 1090                 1095             


Asn Leu  Asn Asp Lys Leu Asn  Gly Tyr Ser Gln Gly  Tyr Lys Glu 
    1100                 1105                 1110             


Lys Tyr  Ile Glu Lys Leu Lys  Glu Asn Ser Asp Phe  Phe Thr Lys 
    1115                 1120                 1125             


Asn Ile  Gln Asn Lys Asn Tyr  Lys Ser Phe Glu Glu  Phe Glu Lys 
    1130                 1135                 1140             


Asn Tyr  Asn Lys Ile Ser Glu  Tyr Lys Lys Ile Arg  Asp Leu Val 
    1145                 1150                 1155             


Glu Phe  Asn Tyr Leu Asn Lys  Ile Glu Ser Tyr Leu  Ile Asp Ile 
    1160                 1165                 1170             


Asn Trp  Lys Leu Ala Ile Gln  Met Ala Arg Phe Glu  Arg Asp Met 
    1175                 1180                 1185             


His Tyr  Ile Val Asn Gly Leu  Arg Glu Leu Gly Ile  Ile Lys Leu 
    1190                 1195                 1200             


Ser Gly  Tyr Asn Thr Gly Ile  Ser Arg Ala Tyr Pro  Lys Arg Asn 
    1205                 1210                 1215             


Gly Ser  Asp Gly Phe Tyr Thr  Thr Thr Ala Tyr Tyr  Lys Phe Phe 
    1220                 1225                 1230             


Asp Glu  Glu Ser Tyr Lys Lys  Phe Glu Lys Ile Cys  Tyr Gly Phe 
    1235                 1240                 1245             


Gly Ile  Asp Leu Ser Glu Asn  Ser Glu Ile Asn Lys  Pro Glu Asn 
    1250                 1255                 1260             


Glu Ser  Ile Arg Asn Tyr Ile  Ser His Phe Tyr Ile  Val Arg Asn 
    1265                 1270                 1275             


Pro Phe  Val Asp Tyr Ser Ile  Ala Glu Gln Ile Asp  Arg Val Ser 
    1280                 1285                 1290             


Asn Leu  Leu Ser Tyr Ser Thr  Arg Tyr Asn Asn Ser  Thr Tyr Ala 
    1295                 1300                 1305             


Ser Val  Phe Glu Val Phe Lys  Lys Asp Val Asn Leu  Asp Tyr Asp 
    1310                 1315                 1320             


Lys Leu  Lys Ile Lys Phe Lys  Leu Phe Asp Asp Glu  Lys Asn Asp 
    1325                 1330                 1335             


Asp Ile  Lys Ile Leu Lys Ile  Glu Asp Leu Ile Glu  Ser Lys Lys 
    1340                 1345                 1350             


Val Ser  Val Leu Glu Leu Glu  Ser Tyr Asn Ser Asp  Tyr Ile Lys 
    1355                 1360                 1365             


Asn Leu  Ile Ile Glu Leu Leu  Thr Lys Val Glu Asn  Lys Asp Glu 
    1370                 1375                 1380             


Ile Ser  Ser 
    1385     


<210>  574
<211>  1194
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  574

Met Lys Val Thr Lys Ile Asp Gly Leu Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Phe Lys Asn Asn Lys Asn Ile Asn Glu Ile 
            20                  25                  30          


Lys Glu Arg Leu Lys Lys Leu Lys Glu Leu Lys Leu Asp Asn Tyr Ile 
        35                  40                  45              


Lys Asn Pro Glu Asn Val Lys Asn Lys Asp Lys Asp Ala Glu Lys Glu 
    50                  55                  60                  


Thr Lys Ile Arg Arg Thr Asn Leu Lys Lys Tyr Phe Ser Glu Ile Ile 
65                  70                  75                  80  


Leu Arg Lys Glu Asp Glu Lys Tyr Ile Leu Lys Lys Thr Lys Lys Phe 
                85                  90                  95      


Lys Asn Ile Asn Gln Glu Ile Asp Tyr Tyr Asp Val Lys Ser Lys Lys 
            100                 105                 110         


Asn Gln Gln Glu Ile Phe Asp Val Leu Lys Glu Ile Lys Ile Lys Glu 
        115                 120                 125             


Thr Glu Lys Glu Glu Ile Ile Thr Phe Asp Ser Glu Lys Leu Lys Lys 
    130                 135                 140                 


Val Phe Gly Glu Asp Phe Val Lys Lys Glu Ala Lys Ile Lys Ala Ile 
145                 150                 155                 160 


Glu Lys Ser Leu Lys Ile Asn Lys Ala Asn Tyr Lys Lys Asp Ser Ile 
                165                 170                 175     


Lys Ile Gly Asp Asp Lys Tyr Ser Asn Val Lys Gly Glu Asn Lys Arg 
            180                 185                 190         


Ser Arg Ile Tyr Glu Tyr Tyr Lys Lys Ser Glu Asn Leu Lys Lys Phe 
        195                 200                 205             


Glu Glu Asn Ile Arg Glu Ala Phe Glu Lys Leu Tyr Thr Glu Glu Asn 
    210                 215                 220                 


Ile Lys Glu Leu Tyr Ser Lys Ile Glu Glu Val Leu Lys Lys Thr His 
225                 230                 235                 240 


Leu Lys Ser Ile Val Arg Glu Phe Tyr Gln Asn Glu Ile Ile Gly Glu 
                245                 250                 255     


Ser Glu Phe Ser Lys Lys Asn Gly Asp Gly Ile Ser Ile Leu Tyr Asn 
            260                 265                 270         


Gln Ile Lys Asp Ser Ile Lys Lys Glu Glu Asn Phe Ile Glu Phe Ile 
        275                 280                 285             


Glu Asn Ile Gly Asn Leu Lys Leu Lys Asp Leu Thr Lys Ser Gln Ile 
    290                 295                 300                 


Phe Tyr Lys Tyr Phe Leu Glu Asn Glu Glu Leu Asn Asp Glu Asn Ile 
305                 310                 315                 320 


Lys Phe Ala Phe Cys Tyr Phe Val Glu Ile Glu Val Asn Asn Leu Leu 
                325                 330                 335     


Lys Glu Asn Val Tyr Lys Ile Lys Arg Phe Asn Glu Gly Asn Lys Lys 
            340                 345                 350         


Arg Ile Lys Asn Ile Phe Glu Tyr Gly Lys Leu Lys Lys Leu Ile Val 
        355                 360                 365             


Tyr Lys Leu Glu Asn Lys Leu Asn Asn Tyr Val Arg Asn Cys Gly Lys 
    370                 375                 380                 


Tyr Asn Tyr His Met Glu Asn Gly Asp Ile Ala Thr Ser Asp Ile Asn 
385                 390                 395                 400 


Met Arg Asn Arg Gln Thr Glu Ala Phe Leu Arg Ser Ile Ile Gly Val 
                405                 410                 415     


Ser Ser Phe Gly Tyr Phe Ser Leu Arg Asn Ile Leu Gly Val Asn Asp 
            420                 425                 430         


Asp Asp Phe Tyr Glu Ile Glu Glu Gly Leu Thr Glu Glu Glu Arg Lys 
        435                 440                 445             


Asn Glu Ser Asn Val Leu Lys Lys Ala Lys Glu Asp Ile Thr Ser Lys 
    450                 455                 460                 


Ser Ile Phe Glu Lys Val Val Asp Lys Ser Phe Glu Lys Lys Gly Ile 
465                 470                 475                 480 


His Ser Ile Arg Lys Asn Val Lys Met Phe Tyr Gly Asp Ser Phe Asp 
                485                 490                 495     


Lys Ala Asn Glu Asp Glu Leu Lys Gln Phe Phe Val Asn Met Leu Asn 
            500                 505                 510         


Ala Ile Thr Ser Ile Arg His Arg Val Val His Tyr Asn Met Asn Thr 
        515                 520                 525             


Asn Ser Glu Asn Ile Phe Asn Phe Ser Asp Ile Glu Val Ser Arg Leu 
    530                 535                 540                 


Leu Lys Ser Ile Phe Glu Lys Glu Thr Asp Lys Arg Glu Leu Lys Leu 
545                 550                 555                 560 


Lys Ile Phe Arg Gln Leu Asn Ser Ala Gly Val Phe Asp Tyr Trp Glu 
                565                 570                 575     


Asn Trp Lys Ile Glu Lys Tyr Leu Lys Asn Ile Glu Phe Lys Phe Val 
            580                 585                 590         


Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys Leu Tyr Asn Arg 
        595                 600                 605             


Ile Asp Asn Leu Lys Ala Gly Asn Ala Leu Lys Leu Gly Asn His Ile 
    610                 615                 620                 


Ile Ile Pro Lys Arg Lys Glu Ala Arg Asp Ser Gln Ile Tyr Leu Leu 
625                 630                 635                 640 


Lys Asn Ile Tyr Tyr Gly Glu Phe Val Glu Lys Phe Val Asn Asn Asn 
                645                 650                 655     


Asp Asn Phe Glu Lys Ile Phe Arg Glu Ile Ile Lys Ile Asn Lys Asn 
            660                 665                 670         


Ala Gly Thr Asn Thr Lys Thr Lys Phe Tyr Lys Leu Glu Lys Phe Glu 
        675                 680                 685             


Thr Leu Lys Ala Asn Thr Pro Thr Glu Tyr Leu Glu Lys Leu Gln Ser 
    690                 695                 700                 


Leu His Lys Ile Asn Tyr Asp Lys Glu Lys Val Glu Glu Asp Lys Asp 
705                 710                 715                 720 


Thr Tyr Val Asp Phe Val Gln Lys Ile Phe Leu Lys Gly Phe Ile Asn 
                725                 730                 735     


Tyr Leu Gln Lys Ser Asn Ser Leu Lys Pro Leu Asn Leu Leu Asn Leu 
            740                 745                 750         


Lys Lys Asp Glu Val Ile Asn Ser Glu Lys Ser Ser Tyr Asp Glu Lys 
        755                 760                 765             


Leu Lys Gln Trp Glu Asn Asn Gly Ser Lys Leu Ser Glu Met Pro Lys 
    770                 775                 780                 


Glu Ile Tyr Glu Tyr Ile Lys Lys Ile Gln Ile Asn Lys Ile Asn Tyr 
785                 790                 795                 800 


Ser Asn Arg Met Ser Ile Phe Tyr Leu Leu Leu Lys Leu Ile Asp His 
                805                 810                 815     


Arg Glu Leu Thr Asn Leu Arg Gly Asn Leu Glu Lys Tyr Glu Ser Met 
            820                 825                 830         


Asn Lys Asn Glu Ile Tyr Ser Glu Glu Leu Asn Ile Val Asn Leu Val 
        835                 840                 845             


Ser Leu Asp Asn Asn Lys Val Arg Ala Asn Phe Asn Leu Glu Ser Glu 
    850                 855                 860                 


Asp Ile Gly Lys Phe Leu Lys Thr Glu Thr Ser Ile Lys Asn Ile Asn 
865                 870                 875                 880 


Gln Leu Asn Asn Phe Ser Gly Ile Phe Ala Asp Gly Glu Asn Val Ile 
                885                 890                 895     


Lys His Arg Ser Phe Tyr Asn Ile Lys Lys Tyr Gly Ile Leu Asp Leu 
            900                 905                 910         


Leu Glu Lys Ile Val Ala Lys Ala Asp Leu Lys Ile Ala Lys Glu Glu 
        915                 920                 925             


Ile Lys Lys Tyr Glu Asn Leu Gln Asn Glu Leu Lys Arg Asn Asp Phe 
    930                 935                 940                 


Tyr Lys Ile Gln Glu Lys Ile His Arg Lys Tyr Asn Gln Lys Pro Asn 
945                 950                 955                 960 


Leu Ile Leu Arg Thr Glu Asn Lys Lys Asp Phe Asn Asp Tyr Lys Lys 
                965                 970                 975     


Ala Ile Glu Asn Ile Gln Asn Tyr Thr Gln Leu Lys Asn Lys Ile Glu 
            980                 985                 990         


Phe Asn Asp Leu Asn Leu Leu Gln  Gly Leu Leu Phe Arg  Ile Leu His 
        995                 1000                 1005             


Arg Leu  Ala Gly Tyr Thr Ser  Leu Trp Glu Arg Asp  Leu Gln Phe 
    1010                 1015                 1020             


Lys Leu  Lys Gly Glu Phe Pro  Glu Asp Lys Tyr Ile  Asp Glu Ile 
    1025                 1030                 1035             


Phe Asn  Ser Asp Arg Asn Asn  Asn Gln Lys Tyr Lys  Ser Gly Gly 
    1040                 1045                 1050             


Ile Ala  Tyr Lys Tyr Val Asp  Phe Leu Ile Glu Lys  Glu Glu Gly 
    1055                 1060                 1065             


Lys Arg  Ala Gly Lys Asn Lys  Val Lys Lys Arg Ser  Glu Lys Glu 
    1070                 1075                 1080             


Gly Ser  Phe Ile Ile Arg Asn  Tyr Ile Ala His Phe  Asn Tyr Ile 
    1085                 1090                 1095             


Pro Asp  Ala Glu Lys Ser Ile  Leu Glu Ile Leu Glu  Glu Leu Arg 
    1100                 1105                 1110             


Glu Leu  Leu Lys Tyr Asp Arg  Lys Leu Lys Asn Ala  Val Met Lys 
    1115                 1120                 1125             


Ser Val  Lys Asp Ile Phe Lys  Glu Tyr Gly Phe Ile  Val Glu Phe 
    1130                 1135                 1140             


Arg Ile  Ser His Glu Ser Asn  Ser Lys Lys Ile Lys  Val Leu Asp 
    1145                 1150                 1155             


Val Lys  Ser Glu Lys Ile Lys  His Leu Lys Asn Asn  Gly Leu Val 
    1160                 1165                 1170             


Thr Thr  Lys Asn Ser Glu Asp  Leu Cys Glu Leu Val  Lys Val Met 
    1175                 1180                 1185             


Leu Glu  Tyr Lys Lys Ser 
    1190                 


<210>  575
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  575

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Leu Tyr Gln Ile Val  Ser Ala Phe Asn Phe  Gly Ser Lys 
    1205                 1210                 1215             


Leu Leu  Tyr Ile Ser Glu Asp  Gly Arg Trp Lys Met  Ala Gly Gly 
    1220                 1225                 1230             


Ala Phe  Pro Gly Lys Tyr Gly  Arg Phe Glu Asn Asp  Tyr Asn His 
    1235                 1240                 1245             


Arg Thr  Ser Leu Ser Lys Val  Ile Arg Leu Phe Glu  Asn Glu Ser 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ile Ile Tyr  Trp Arg Asp Tyr Val  Asp His Met 
    1265                 1270                 1275             


Lys Tyr  Tyr Val Asn Gln Asn  Gln Ser Ile Met Glu  Ile Tyr Ser 
    1280                 1285                 1290             


Ala Phe  Tyr Ser Lys Val Leu  Gly Tyr Ser Ala Lys  Leu Arg Lys 
    1295                 1300                 1305             


Ser Val  Val Phe Asn Leu Gln  Ala Ala Leu Glu Lys  His His Ile 
    1310                 1315                 1320             


Asn Pro  Glu Cys Ile Trp Met  Thr Ser Asp Gly Lys  Cys Ala Asp 
    1325                 1330                 1335             


Ile Lys  Leu Met Lys Asn Leu  Glu Ser Gln Lys Phe  Thr Tyr Lys 
    1340                 1345                 1350             


Leu Ala  Lys Arg Glu Gly Glu  Lys Thr Glu Arg Lys  Ile Cys Met 
    1355                 1360                 1365             


Asn Ala  Leu Asn Glu Asn Phe  Leu Lys Thr Ile Arg  Thr Ser Leu 
    1370                 1375                 1380             


Glu Tyr  Lys Lys 
    1385         


<210>  576
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  576

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Gly Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Leu Tyr Gln Ile Val  Ser Ala Phe Asn Phe  Gly Ser Lys 
    1205                 1210                 1215             


Leu Leu  Tyr Ile Ser Glu Asp  Gly Arg Trp Lys Met  Ala Gly Gly 
    1220                 1225                 1230             


Ala Phe  Pro Gly Lys Tyr Gly  Arg Phe Glu Asn Asp  Tyr Asn His 
    1235                 1240                 1245             


Arg Thr  Ser Leu Ser Lys Val  Ile Arg Leu Phe Glu  Asn Glu Ser 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ile Ile Tyr  Trp Arg Asp Tyr Val  Asp His Met 
    1265                 1270                 1275             


Lys Tyr  Tyr Val Asn Gln Asn  Gln Ser Ile Met Glu  Ile Tyr Ser 
    1280                 1285                 1290             


Ala Phe  Tyr Ser Lys Val Leu  Gly Tyr Ser Ala Lys  Leu Arg Lys 
    1295                 1300                 1305             


Ser Val  Val Phe Asn Leu Gln  Ala Ala Leu Glu Lys  His His Ile 
    1310                 1315                 1320             


Asn Pro  Glu Cys Ile Trp Met  Thr Ser Asp Gly Lys  Cys Ala Asp 
    1325                 1330                 1335             


Ile Lys  Leu Met Lys Asn Leu  Glu Ser Gln Lys Phe  Thr Tyr Lys 
    1340                 1345                 1350             


Leu Ala  Lys Arg Glu Gly Glu  Lys Thr Glu Arg Lys  Ile Cys Met 
    1355                 1360                 1365             


Asn Ala  Leu Asn Glu Asn Phe  Leu Lys Thr Ile Arg  Thr Ser Leu 
    1370                 1375                 1380             


Glu Tyr  Lys Lys 
    1385         


<210>  577
<211>  1101
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  577

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Thr Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Ser Ala Cys Thr Ser Leu 
465                 470                 475                 480 


Ala Gln Val Cys Gln Ile Tyr Met Thr Glu Tyr Asn Gln Gln Asn Asn 
                485                 490                 495     


Gln Ile Lys Lys Val Arg Ser Ser Asn Asp Ser Ile Phe Asp Gln Pro 
            500                 505                 510         


Val Tyr Gln His Tyr Lys Val Leu Leu Lys Lys Ala Ile Ala Asn Ala 
        515                 520                 525             


Phe Ala Asp Tyr Leu Lys Asn Asn Lys Asp Leu Phe Gly Phe Ile Gly 
    530                 535                 540                 


Lys Pro Phe Lys Ala Asn Glu Ile Arg Glu Ile Asp Lys Glu Gln Phe 
545                 550                 555                 560 


Leu Pro Asp Trp Thr Ser Arg Lys Tyr Glu Ala Leu Cys Ile Glu Val 
                565                 570                 575     


Ser Gly Ser Gln Glu Leu Gln Lys Trp Tyr Ile Val Gly Lys Phe Leu 
            580                 585                 590         


Asn Ala Arg Ser Leu Asn Leu Met Val Gly Ser Met Arg Ser Tyr Ile 
        595                 600                 605             


Gln Tyr Val Thr Asp Ile Lys Arg Arg Ala Ala Ser Ile Gly Asn Glu 
    610                 615                 620                 


Leu His Val Ser Val His Asp Val Glu Lys Val Glu Lys Trp Val Gln 
625                 630                 635                 640 


Val Ile Glu Val Cys Ser Leu Leu Ala Ser Arg Thr Ser Asn Gln Phe 
                645                 650                 655     


Glu Asp Tyr Phe Asn Asp Lys Asp Asp Tyr Ala Arg Tyr Leu Lys Ser 
            660                 665                 670         


Tyr Val Asp Phe Ser Asn Val Asp Met Pro Ser Glu Tyr Ser Ala Leu 
        675                 680                 685             


Val Asp Phe Ser Asn Glu Glu Gln Ser Asp Leu Tyr Val Asp Pro Lys 
    690                 695                 700                 


Asn Pro Lys Val Asn Arg Asn Ile Val His Ser Lys Leu Phe Ala Ala 
705                 710                 715                 720 


Asp His Ile Leu Arg Asp Ile Val Glu Pro Val Ser Lys Asp Asn Ile 
                725                 730                 735     


Glu Glu Phe Tyr Ser Gln Lys Ala Glu Ile Ala Tyr Cys Lys Ile Lys 
            740                 745                 750         


Gly Lys Glu Ile Thr Ala Glu Glu Gln Lys Ala Val Leu Lys Tyr Gln 
        755                 760                 765             


Lys Leu Lys Asn Arg Val Glu Leu Arg Asp Ile Val Glu Tyr Gly Glu 
    770                 775                 780                 


Ile Ile Asn Glu Leu Leu Gly Gln Leu Ile Asn Trp Ser Phe Met Arg 
785                 790                 795                 800 


Glu Arg Asp Leu Leu Tyr Phe Gln Leu Gly Phe His Tyr Asp Cys Leu 
                805                 810                 815     


Arg Asn Asp Ser Lys Lys Pro Glu Gly Tyr Lys Asn Ile Lys Val Asp 
            820                 825                 830         


Glu Asn Ser Ile Lys Asp Ala Ile Leu Tyr Gln Ile Ile Gly Met Tyr 
        835                 840                 845             


Val Asn Gly Val Thr Val Tyr Ala Pro Glu Lys Asp Gly Asp Lys Leu 
    850                 855                 860                 


Lys Glu Gln Cys Val Lys Gly Gly Val Gly Val Lys Val Ser Ala Phe 
865                 870                 875                 880 


His Arg Tyr Ser Lys Tyr Leu Gly Leu Asn Glu Lys Thr Leu Tyr Asn 
                885                 890                 895     


Ala Gly Leu Glu Ile Phe Glu Val Val Ala Glu His Glu Asp Ile Ile 
            900                 905                 910         


Asn Leu Arg Asn Gly Ile Asp His Phe Lys Tyr Tyr Leu Gly Asp Tyr 
        915                 920                 925             


Arg Ser Met Leu Ser Ile Tyr Ser Glu Val Phe Asp Arg Phe Phe Thr 
    930                 935                 940                 


Tyr Asp Ile Lys Tyr Gln Lys Asn Val Leu Asn Leu Leu Gln Asn Ile 
945                 950                 955                 960 


Leu Leu Arg His Asn Val Ile Val Glu Pro Ile Leu Glu Ser Gly Phe 
                965                 970                 975     


Lys Thr Ile Gly Glu Gln Thr Lys Pro Gly Ala Lys Leu Ser Ile Arg 
            980                 985                 990         


Ser Ile Lys Ser Asp Thr Phe Gln  Tyr Lys Val Lys Gly  Gly Thr Leu 
        995                 1000                 1005             


Ile Thr  Asp Ala Lys Asp Glu  Arg Tyr Leu Glu Thr  Ile Arg Lys 
    1010                 1015                 1020             


Ile Leu  Tyr Tyr Ala Glu Asn  Glu Glu Asp Asn Leu  Lys Lys Ser 
    1025                 1030                 1035             


Val Val  Val Thr Asn Ala Asp  Lys Tyr Glu Lys Asn  Lys Glu Ser 
    1040                 1045                 1050             


Asp Asp  Gln Asn Lys Gln Lys  Glu Lys Lys Asn Lys  Asp Asn Lys 
    1055                 1060                 1065             


Gly Lys  Lys Asn Glu Glu Thr  Lys Ser Asp Ala Glu  Lys Asn Asn 
    1070                 1075                 1080             


Asn Glu  Arg Leu Ser Tyr Asn  Pro Phe Ala Asn Leu  Asn Phe Lys 
    1085                 1090                 1095             


Leu Leu  Asn 
    1100     


<210>  578
<211>  1244
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  578

Met Lys Ile Thr Lys Ile Asp Gly Val Ser His Tyr Lys Glu Lys Glu 
1               5                   10                  15      


Lys Gly Val Leu Lys Gly Lys Asp Ile Leu Asn Gly Lys Ile Glu Lys 
            20                  25                  30          


Ile Val Lys Lys Arg Tyr Asp Ala Thr Ile Glu Ser Lys Ile Tyr Lys 
        35                  40                  45              


Glu Phe Ile Lys Leu Arg Lys Asn Arg Ile Glu Gln Asn Asn Glu Lys 
    50                  55                  60                  


Ser Ile Leu Glu Leu Ile Lys Ser Asn Ile Asp Lys Asn Glu Lys Glu 
65                  70                  75                  80  


Ile Lys Thr Leu Leu Trp Lys Asn Phe Lys Ile Lys Glu Lys Asn Lys 
                85                  90                  95      


Asn Tyr Asp Glu Tyr Ile Thr Asp Glu Ile Lys Leu Asp Asn Asp Ile 
            100                 105                 110         


Lys Ile Tyr Glu Ser Val Glu Ser Leu Tyr Phe Leu Ile Lys Glu Ile 
        115                 120                 125             


Tyr Leu Gly Gln Asn Asn Lys Lys Trp Asn Ile Ser Lys Ile Asp Leu 
    130                 135                 140                 


Glu Lys Ile Met Glu Glu Asp Ser Asp Leu Ile Met Leu Gly Tyr Lys 
145                 150                 155                 160 


Leu Lys Lys Asn Ile Lys Glu Asp Asp Tyr Pro Tyr Leu Tyr Arg Asp 
                165                 170                 175     


Lys Asn Gly Gln Glu Ser Thr Ser Val Tyr Lys Leu Leu Lys Lys Leu 
            180                 185                 190         


Ile Glu Glu Asn Lys Asp Arg Asn Gln Asp Ile Arg Lys Ser Gln Glu 
        195                 200                 205             


Tyr Glu Lys Ile Arg Lys Asn Phe Glu Glu Tyr Lys Asn Arg Lys Ile 
    210                 215                 220                 


Asn Leu Leu Val Lys Ser Ile Lys Asn Asn Lys Ile Asn Ile Gln Tyr 
225                 230                 235                 240 


Ile Asn Asn Glu Ile Lys Ser His Asp Asn Pro Arg Glu Glu Asn Ile 
                245                 250                 255     


Ile Lys Phe Phe Arg Lys Met Ile Glu Glu Lys Asn Lys Pro Ile Leu 
            260                 265                 270         


Lys Asp Lys Leu Lys Leu Phe Arg Leu Glu Val Phe Phe Asn Glu Glu 
        275                 280                 285             


Phe Leu Glu Glu Ile Lys Lys Leu Leu Asp Ser Asp Asp Ser Asp Lys 
    290                 295                 300                 


Ser Gln Asn Lys Lys Ile Ser Glu Leu Arg Gly Lys Ile Phe Asn Arg 
305                 310                 315                 320 


Ile Arg Glu Glu Ile Lys Asn Asn Lys Asn Arg Asp Glu Leu Glu Asn 
                325                 330                 335     


Ile Tyr Phe Leu Glu Leu Lys Lys Tyr Ile Glu Asn Asn Leu Ser His 
            340                 345                 350         


Lys Lys Glu Lys Asn Lys Asn Ser Asn Asn Thr Gly Glu Glu Lys Ser 
        355                 360                 365             


Lys Lys Leu Tyr Leu Lys Phe Leu Lys Lys Val Leu Phe Ile Asp Asp 
    370                 375                 380                 


Asn Asn Arg Ile Ser Ile Glu Lys Leu Lys Ser Arg Ile Asp Asp Asn 
385                 390                 395                 400 


Phe Lys Asn Leu Leu Ile Gln His Val Ile Glu Tyr Gly Lys Ile Lys 
                405                 410                 415     


Tyr Tyr Val Glu Asn Asp Asp Tyr Ile Arg Asn Ile Val Lys Asn Gly 
            420                 425                 430         


Glu Leu Lys Leu Glu Thr Lys Asp Leu Glu Tyr Ile Lys Thr Lys Glu 
        435                 440                 445             


Thr Leu Ile Arg Lys Met Ala Val Leu Val Ser Phe Ala Ala Asn Ser 
    450                 455                 460                 


Tyr Tyr Asn Leu Phe Gly Ser Ala Ser Glu Asp Ile Leu Gly Thr Glu 
465                 470                 475                 480 


Val Val Lys Asn Arg Arg Thr Asn Val Ile Lys Val Lys Ser Tyr Ile 
                485                 490                 495     


Phe Lys Glu Lys Met Leu Asn Tyr Phe Phe Asp Ser Glu Asp Phe Asp 
            500                 505                 510         


Val Asn Lys Thr Ile Glu Val Leu Glu Ser Ile Ser Tyr Ser Ile Tyr 
        515                 520                 525             


Asn Ile Arg Asn Gly Val Gly His Phe Asn Lys Leu Val Leu Gly Lys 
    530                 535                 540                 


Tyr Lys Lys Lys Asp Ile Ser Thr Asn Lys Arg Val Glu Glu Asp Leu 
545                 550                 555                 560 


Asn Asn Asn Glu Glu Ile Lys Gly Tyr Phe Ile Lys Lys Arg Gly Glu 
                565                 570                 575     


Ile Glu Lys Lys Ile Lys Glu Arg Phe Leu Ser Asn Asn Leu Gln Tyr 
            580                 585                 590         


Tyr Tyr Ala Lys Glu Arg Ile Glu Asn Tyr Phe Glu Val Tyr Glu Phe 
        595                 600                 605             


Glu Ile Leu Lys Glu Lys Ile Pro Phe Ala Pro Asn Phe Lys Arg Ile 
    610                 615                 620                 


Ile Lys Lys Gly Glu Asn Leu Leu Asn Asn Lys Lys Tyr Glu Tyr Phe 
625                 630                 635                 640 


Lys Asn Phe Asp Lys Asn Ser Val Glu Glu Lys Lys Glu Phe Leu Lys 
                645                 650                 655     


Thr Arg Asn Phe Leu Leu Lys Glu Leu Tyr Tyr Asn Asn Phe Tyr Lys 
            660                 665                 670         


Glu Phe Leu Ser Lys Lys Glu Glu Phe Lys Lys Ile Val Ile Glu Val 
        675                 680                 685             


Lys Glu Glu Lys Lys Asn Arg Gly Asn Asn Lys Lys Ser Gly Val Ser 
    690                 695                 700                 


Phe Gln Ser Ile Asp Asp Tyr Asp Thr Lys Ile Asn Ile Ser Asp Tyr 
705                 710                 715                 720 


Ile Ala Ser Ile His Lys Lys Glu Met Glu Arg Val Glu Lys Tyr Asn 
                725                 730                 735     


Glu Glu Lys Gln Lys Asp Thr Ala Lys Tyr Ile Arg Asp Phe Val Glu 
            740                 745                 750         


Glu Ile Phe Leu Thr Gly Phe Ile Asn Tyr Leu Glu Lys Asp Lys Arg 
        755                 760                 765             


Leu His Phe Leu Lys Glu Glu Phe Ser Ile Leu Cys Asn Asn Asn Asn 
    770                 775                 780                 


Val Val Asp Phe Asn Ile Asn Ile Asn Glu Glu Lys Ile Lys Glu Phe 
785                 790                 795                 800 


Leu Lys Glu Asn Asp Ser Lys Thr Leu Asn Leu Tyr Leu Phe Phe Asn 
                805                 810                 815     


Met Ile Asp Ser Lys Arg Ile Ser Glu Phe Arg Asn Glu Leu Ile Lys 
            820                 825                 830         


Tyr Lys Gln Phe Thr Lys Lys Arg Leu Asp Glu Glu Lys Glu Phe Leu 
        835                 840                 845             


Gly Ile Lys Ile Glu Leu Tyr Glu Thr Leu Ile Glu Phe Val Ile Leu 
    850                 855                 860                 


Thr Arg Glu Lys Leu Asp Thr Lys Lys Ser Glu Glu Thr Asp Ala Trp 
865                 870                 875                 880 


Leu Val Asp Lys Leu Tyr Val Lys Glu Lys Asn Glu Cys Asn Glu Tyr 
                885                 890                 895     


Glu Tyr Lys Glu Tyr Glu Glu Ile Leu Lys Leu Phe Val Asp Glu Lys 
            900                 905                 910         


Ile Leu Asn Ser Lys Glu Ala Pro Tyr Tyr Ala Thr Asn Asn Lys Thr 
        915                 920                 925             


Pro Ile Leu Leu Ser Asn Phe Glu Lys Thr Arg Lys Tyr Gly Thr Gln 
    930                 935                 940                 


Ser Phe Leu Ser Glu Ile Gln Ser Asn Tyr Lys Tyr Ser Lys Val Glu 
945                 950                 955                 960 


Lys Glu Asn Ile Glu Asp Tyr Asn Lys Lys Glu Glu Ile Glu Lys Lys 
                965                 970                 975     


Lys Lys Ser Asn Ile Glu Lys Leu Gln Asp Leu Lys Val Glu Leu His 
            980                 985                 990         


Lys Lys Trp Glu Gln Asn Lys Ile  Thr Glu Lys Glu Ile  Lys Lys Tyr 
        995                 1000                 1005             


Asn Asp  Thr Ile Lys Glu Ile  Arg Glu Tyr Asn Tyr  Leu Lys Asn 
    1010                 1015                 1020             


Lys Glu  Glu Leu Gln Asn Val  Tyr Leu Leu His Glu  Ile Leu Ser 
    1025                 1030                 1035             


Asp Leu  Leu Ala Arg Asn Val  Ala Phe Phe Asn Lys  Trp Glu Arg 
    1040                 1045                 1050             


Asp Phe  Lys Phe Ile Val Ile  Ala Ile Lys Gln Phe  Leu Arg Glu 
    1055                 1060                 1065             


Asn Asp  Lys Glu Lys Val Glu  Asn Phe Leu Asn Pro  Leu Asp Asn 
    1070                 1075                 1080             


Ser Lys  Gly Lys Lys Val Tyr  Phe Ser Val Ser Lys  Tyr Lys Asn 
    1085                 1090                 1095             


Thr Val  Glu Asn Ile Asp Gly  Ile His Lys Asn Phe  Met Asn Leu 
    1100                 1105                 1110             


Ile Phe  Leu Asn Asn Lys Phe  Met Asn Arg Lys Ile  Asp Lys Met 
    1115                 1120                 1125             


Asn Cys  Thr Ile Trp Val Tyr  Phe Arg Asn Tyr Ile  Ala His Phe 
    1130                 1135                 1140             


Leu His  Leu His Thr Lys Asn  Glu Lys Ile Ser Leu  Ile Asn Gln 
    1145                 1150                 1155             


Met Asn  Leu Leu Ile Lys Leu  Phe Ser Tyr Asp Lys  Lys Val Gln 
    1160                 1165                 1170             


Asn His  Ile Leu Lys Ser Thr  Lys Thr Leu Leu Glu  Lys Tyr Asn 
    1175                 1180                 1185             


Ile Gln  Ile Asn Phe Glu Ile  Ser Asn Asp Lys Asn  Glu Val Phe 
    1190                 1195                 1200             


Lys Tyr  Lys Ile Lys Asn Arg  Leu Tyr Ser Lys Lys  Gly Lys Met 
    1205                 1210                 1215             


Leu Gly  Lys Asn Asn Lys Phe  Glu Ile Leu Glu Asn  Glu Phe Leu 
    1220                 1225                 1230             


Glu Asn  Val Lys Ala Met Leu  Glu Tyr Ser Glu 
    1235                 1240                 


<210>  579
<211>  949
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  579

Met Pro His Gln Lys Lys Met Ala Glu Arg Ile Lys Phe Val Asn Tyr 
1               5                   10                  15      


Gly Tyr Tyr Leu Arg Leu Lys Lys Asn Cys Ala Asp Ser Phe Glu Tyr 
            20                  25                  30          


Tyr Trp Cys Asp Tyr Ile Lys Glu Phe Ile Glu Glu Asn Tyr Val Thr 
        35                  40                  45              


Lys Ile Lys Glu Ala Lys Gly Lys Asn Gly Arg Gln Leu Thr Glu Glu 
    50                  55                  60                  


Asn Cys Asn Ser Glu Ala Met Leu Ser Lys Cys Trp His Asp Met Ile 
65                  70                  75                  80  


Arg His Met Cys Ala Lys Tyr Met Asp Leu Gly Lys Ala Val Tyr His 
                85                  90                  95      


Phe Met Leu Pro Gly Lys Ala Glu Gly Asn Asp Leu Cys Leu Asp Arg 
            100                 105                 110         


Leu Asn Asp Ser Phe Ser Lys Gly Ile Thr Ser Phe Asp Tyr Glu Asn 
        115                 120                 125             


Ile Lys Ala Glu Glu Asn Leu Gln Lys Ala Met Phe Gly Val Leu Val 
    130                 135                 140                 


Ser Gly Thr Phe Asn Phe Ser Arg Ser Val Ala Asp Tyr Ser Gly Pro 
145                 150                 155                 160 


Ala Ala Ala Lys Leu Ala Lys Glu Leu Arg Ala Glu Gly Lys Thr Leu 
                165                 170                 175     


Asn Glu Asp Val Leu Met Val Asp Glu Ala His Leu Lys Ala Ile Leu 
            180                 185                 190         


Tyr Ser Asp Ala Lys Arg Lys Leu Leu Arg Tyr Phe Gly Gly Ser Ser 
        195                 200                 205             


Ala Cys Glu Ala Leu Gly Leu Asp Lys Asp Lys Met Val Leu Glu Phe 
    210                 215                 220                 


Arg Gln Ile Phe Arg Gly Leu Arg Asn Ser Ala Phe His Tyr Thr Asp 
225                 230                 235                 240 


Gly Lys Lys Ala Asp Ile Lys Phe Asp Val Thr Arg Gln Leu Trp Ile 
                245                 250                 255     


Gln Asp Val Gln Ala Asn Lys Gln Leu Ile Leu Asp Lys Tyr Tyr Ser 
            260                 265                 270         


Asn Asn Val Cys Arg Tyr Tyr Lys Pro Glu Met Val Lys Lys Leu Ile 
        275                 280                 285             


Gly Asn Leu Tyr His Gly Tyr Val Glu Gln Glu Ala Gln Ile Pro Ala 
    290                 295                 300                 


Phe Arg Thr Val Trp Lys Arg Lys Asp Phe Ala Lys Tyr Leu Asn Asp 
305                 310                 315                 320 


Ser Asn Phe Leu Pro Val Asn Ile Lys Asn Asp Val Lys Glu Arg Thr 
                325                 330                 335     


Val Phe Glu Gly Ala Leu Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg 
            340                 345                 350         


Lys Tyr Thr Val Gly Gln Asp Ala Pro Lys Tyr Phe Phe Glu Ala Val 
        355                 360                 365             


Arg Ala Tyr Ser Asp Glu His Ala Lys Asn Lys Gln Asp Pro Tyr Ala 
    370                 375                 380                 


Asn Gln Ala Lys Asn Phe Trp Asp Tyr Val Glu Lys Leu Gln Lys Ser 
385                 390                 395                 400 


Tyr Glu Lys Gly Thr Leu Thr Phe Gly Ala Val Cys Gln Thr Ile Met 
                405                 410                 415     


Thr Glu Phe Val Gln Gln Asn Ser Lys Ala Thr Glu Lys Glu Gly Glu 
            420                 425                 430         


Ile Tyr Gln His Phe Lys Val Leu Phe Pro Leu Cys Met Gln Arg Gly 
        435                 440                 445             


Phe Glu Lys Tyr Val Lys Glu Lys His Gly Tyr Leu Leu Lys Pro Trp 
    450                 455                 460                 


Leu Asp Thr Val Val Arg Glu Asn Val Leu Gln Asp Ala Ala Ile Thr 
465                 470                 475                 480 


Cys Phe Asp Asp Leu Met Arg Asp Ala Glu Asp Arg Glu Tyr Ser Trp 
                485                 490                 495     


Tyr Val Val Ala His Phe Ile His Pro Lys Lys Leu Asn His Phe Val 
            500                 505                 510         


Gly Ala Leu Lys Asp Tyr Leu Gln Phe Lys Gln Asp Ile Phe Arg Arg 
        515                 520                 525             


Cys Ser Phe Ala Asn Ile Tyr Ser Glu Gly Glu Leu Ser Gln Lys Lys 
    530                 535                 540                 


Ala Met Leu Ala Glu Lys Glu Ala Glu Ile Ser Glu Ile Leu Arg Val 
545                 550                 555                 560 


Met Glu Phe Val Arg Gly Ile Thr Gly Arg Val Ser Lys Thr Phe Ser 
                565                 570                 575     


Asp Tyr Tyr Glu Asn Glu Glu Val Tyr Ala Asn Tyr Leu Gly Lys Tyr 
            580                 585                 590         


Ile Asp Phe Pro Lys Thr Asp Gly Ile Ser Val Phe Glu Ser Phe Arg 
        595                 600                 605             


Asp Phe Cys Thr Asn Thr Leu Pro Asp Gly Asn Val Leu Asp Val Tyr 
    610                 615                 620                 


Met Asp Glu Lys Asn Pro Arg Leu Leu Lys Asn Val Glu Leu Ala Arg 
625                 630                 635                 640 


Met Tyr Ala Gly Gly Asp Val Ala Leu Lys Lys Arg Lys Arg Ile Thr 
                645                 650                 655     


Ala Lys Asp Leu Gln Arg Tyr Tyr Gly Asn Glu Val Ala Val Gln Lys 
            660                 665                 670         


Ile Leu Gln Lys Gly Leu Cys Ser Thr Arg Glu Glu Gln Gln Arg Val 
        675                 680                 685             


Leu Glu Gln Gln Asn Leu Arg Gly Arg Ile Thr Leu Asn Asp Val Thr 
    690                 695                 700                 


Glu Ile Gln Glu Ile Ile Ser Asp Met Leu Ser Gln Leu Val Thr Phe 
705                 710                 715                 720 


Ser Tyr Phe Arg Glu Arg Asp Gln Met Tyr Leu Leu Leu Gly Phe Tyr 
                725                 730                 735     


Tyr Met Ala Leu Gln Thr Asn Arg Gly Ser Ser Trp Gly Asn Glu Thr 
            740                 745                 750         


Ile Asp Phe Cys Ala Gly Lys Lys Ile Ser Ile Lys Gln Gly Trp Val 
        755                 760                 765             


Leu His Gln Val Arg Ser Val Phe Thr Tyr Gly Leu Lys Leu Tyr Ser 
    770                 775                 780                 


Glu Leu Asp Glu Lys Gly Val Gly Gly Gln Leu Ser Ser Lys Ile Val 
785                 790                 795                 800 


Ala Phe Glu Arg Val His Arg Thr Ser Leu Ala Cys Ala Leu Arg Leu 
                805                 810                 815     


Phe Met Asp Glu Asn Cys Ser Arg Arg Ala Val Asp Val Arg Asn Tyr 
            820                 825                 830         


Val Asp His Phe Lys Tyr Tyr Phe Lys Ala Asp Arg Ser Ile Met Glu 
        835                 840                 845             


Leu Tyr Ser Ala Tyr Tyr Asp Cys Phe Phe Asp Tyr Ser Thr Lys Met 
    850                 855                 860                 


Arg Lys Ser Val Leu Leu Asn Phe Ile Ser Ile Leu Glu Arg His Phe 
865                 870                 875                 880 


Val Val Ser Lys Leu Arg Val Asn Cys Leu Glu Glu Arg Cys Ser Val 
                885                 890                 895     


Ser Phe Ala Glu Ser Leu Lys Ser Glu Lys Phe Thr Tyr Lys Leu Glu 
            900                 905                 910         


Ala Asp Ala Asn Lys Lys Ser Lys Glu Gln Thr Val Glu Phe Pro Ala 
        915                 920                 925             


Arg Asp Lys Glu Phe Leu Glu Ser Leu Gln Ala Glu Leu Glu Tyr Lys 
    930                 935                 940                 


Glu Gly Tyr Asn Ser 
945                 


<210>  580
<211>  1073
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  580

Met Arg Ile Val Arg Pro Tyr Gly Glu Ser Val Ala Pro Gly Ala Gly 
1               5                   10                  15      


Ser Glu Arg Leu Leu Arg Pro Lys Lys Gln Leu Arg Asp Gln Ile Gly 
            20                  25                  30          


Asp Ala Asp Arg Arg Ile Pro Thr Phe Ala Ala Gly His Asp Glu Leu 
        35                  40                  45              


Val Ile Ala Gln Trp Ile Ser Thr Ile Asp Lys Ile Ala Thr Lys Pro 
    50                  55                  60                  


Lys Gly Asn Lys Glu Pro Thr Pro Arg Gln Arg Ala Leu Arg Glu Lys 
65                  70                  75                  80  


Leu Gly Lys Ala Gly Trp Asp Arg Leu Val Asp Gln Lys Leu Leu Pro 
                85                  90                  95      


Gly Leu Pro Lys Asp Gln Asp Asp Tyr Leu Gly Lys Leu Trp Trp Phe 
            100                 105                 110         


Lys Ile His Pro Tyr Pro Lys Gly Thr Lys Ala Pro Lys Val Val Asn 
        115                 120                 125             


Gly Arg Glu Ile Pro Asp Pro Arg Gly Arg Trp Tyr Ser Arg Phe Val 
    130                 135                 140                 


Cys Asp Val Ala Pro Asp Asp Ile Asp Ala Ala Thr Val Ala Ala Arg 
145                 150                 155                 160 


Val His Glu His Leu His Val Ala Glu Tyr Arg His Gly Thr Glu Gln 
                165                 170                 175     


Lys His Asp Lys Gly Arg Ile Glu Arg Arg Ala Arg Ser Ile Ala Lys 
            180                 185                 190         


Asn Thr Ala Ser Leu Ala Gln Val Thr Lys Glu Arg Pro Thr Trp Thr 
        195                 200                 205             


Glu Asp Asp Val Ala Thr Tyr Ala Gln Thr Ala Gly Asp Val Ala Thr 
    210                 215                 220                 


Ala Ile Lys Gln Ala Ala Glu Ala Arg Glu Ala Asp Asn Arg Arg Val 
225                 230                 235                 240 


Gly Ala Asp Val Ala Ala Glu Val Leu Tyr Pro Ala Phe Gly Lys Leu 
                245                 250                 255     


Phe Pro Asn Lys Gly Ile Lys Glu Leu Glu Asn Gln Ser Gly Leu Pro 
            260                 265                 270         


Ala Leu His Leu Ala Ile Arg Asp Phe Tyr Gln Arg Arg Leu Lys Arg 
        275                 280                 285             


His Lys Lys Asp Gln Pro Glu His Lys Met Ala Arg Arg Lys Val Ser 
    290                 295                 300                 


Thr Leu Leu Pro Ala Asp Met Ala Gly Leu Ala Ala Met Leu Arg His 
305                 310                 315                 320 


Thr Ala Ala Asn Arg Asp Val Ala Ala Leu Val Arg Leu Gly Lys Val 
                325                 330                 335     


Ile His Tyr Glu Ala Ala Phe Ala Ala Gly Gln Lys Ala Ala Asp Gly 
            340                 345                 350         


Asp Ala Pro Ala His Val Leu Glu Lys Trp Pro Ala Glu Val Lys Ala 
        355                 360                 365             


Ser His Tyr Trp Ser Ser Glu Gly Gln Ala Glu Ile Lys Arg Asn Glu 
    370                 375                 380                 


Ala Phe Val Arg Ile Trp Arg His Ser Leu Ala Leu Ala Ala Gln Thr 
385                 390                 395                 400 


Leu Arg Asp Trp Ala Ser Pro Asp Gly Ser Phe His Thr Asp Ile Leu 
                405                 410                 415     


Ser Glu Lys Gln Phe Glu Thr Leu Thr Lys Asn Leu Asp Leu Asp His 
            420                 425                 430         


His Ala Arg Lys Leu Ala Val Leu Leu Gly Asn Arg Ala Glu Phe Phe 
        435                 440                 445             


Leu Lys Gly Arg Gly Asp Ala Phe Gln Lys Gln Thr Leu Lys Leu Ala 
    450                 455                 460                 


Leu Gln Gly Leu Thr Gln Leu Arg His Asn Ser Phe His Phe Asn Gly 
465                 470                 475                 480 


Arg Gly Gly Phe Ala Asp Ala Leu Lys Phe Thr Arg Lys Pro Glu Ile 
                485                 490                 495     


Thr Ala Asp Gln His Met Trp Asp Ala Leu Gly Ala Leu Trp Ala Thr 
            500                 505                 510         


Asp Leu Glu Glu Arg Gly Lys Arg Leu Ile Asp Thr Leu Glu Ala Ala 
        515                 520                 525             


His Leu His His Phe Phe Asp Trp Glu His Asn Lys Arg Leu Ile Gly 
    530                 535                 540                 


Ala Val Ala Arg Ala Lys Leu Ala Glu Gly Ala Glu Asp Leu Pro Leu 
545                 550                 555                 560 


Pro Arg Phe Arg Arg Leu Leu Asp Arg Ala Ala Asn Ile Arg Gly Lys 
                565                 570                 575     


Asp Gly Ile Asn Leu Arg Leu Pro Lys Pro Val Asn Arg Gln Asp Met 
            580                 585                 590         


Glu Asp Phe Pro Ala Leu His Ala Lys Tyr Val Ala Leu Lys Leu Leu 
        595                 600                 605             


Tyr Glu Asn Pro Phe Arg Gln Trp Val Gly His Arg Asp Arg Arg Asp 
    610                 615                 620                 


Leu Val Asn Lys Leu Ile Asp Arg Ala Val Arg Arg Ala Asp Lys Ala 
625                 630                 635                 640 


Ala Lys Asp Leu His Gly Lys Ala Asp Ala Asp Arg Arg Leu Ile Ile 
                645                 650                 655     


Thr Ala Lys Ala Lys Gly Leu Gly Arg Leu Gly Glu Gly Glu Lys Leu 
            660                 665                 670         


His Asp Phe Ala Phe Arg Leu Ser Arg Glu Thr Ala Ser Glu Met Arg 
        675                 680                 685             


Val Gln Arg Gly Tyr Asp Ser Asp Gly Glu Arg Ala Arg Glu Gln Ala 
    690                 695                 700                 


Ala Phe Ile Glu Glu Leu Leu Ile Asp Val Leu Ala Gln Ala Phe Asp 
705                 710                 715                 720 


His Tyr Leu Arg Lys Lys Lys Phe Asp Phe Leu Val Asp Leu Arg Ala 
                725                 730                 735     


Asp Glu Pro Arg Pro Lys Glu Pro Lys Cys Ala Leu Arg Arg Pro Val 
            740                 745                 750         


Leu Asp Ala Glu Gly Ala Ala Ala Pro Gln Trp Gln Val Leu Leu Tyr 
        755                 760                 765             


Phe Leu Leu His Leu Ile Pro Val Asp Asp Ile Gly Arg Leu Val His 
    770                 775                 780                 


Gln Ile Arg Lys Trp Asp Ile Thr Ala Gly Lys Ala Ala Gly Thr Thr 
785                 790                 795                 800 


Arg Ala Ala Asp Asp Asp Val Asp Arg Val Ala Arg Thr Leu Thr Leu 
                805                 810                 815     


Tyr Leu Asp Met His Asp Ala Lys Phe Thr Gly Asp Gln Ala Leu Gln 
            820                 825                 830         


Ala Leu Ala Pro Leu His Glu Leu Tyr Ala Ser Lys Glu Thr Phe Glu 
        835                 840                 845             


Arg Phe Phe Leu Arg Lys Ala Thr Asp Asp Asn Glu Tyr Leu Pro Arg 
    850                 855                 860                 


Arg Gly Leu Arg Glu Ile Leu Arg Phe Gly His Leu Pro Pro Leu Arg 
865                 870                 875                 880 


Ala Ile Phe Ala Ala His Lys Val Asp Asp Asp Thr Val Gln Lys Val 
                885                 890                 895     


Glu Ala Ala Glu Lys Gly Pro Leu Val Ala Ala Gln Arg Glu Arg Glu 
            900                 905                 910         


Arg Leu His Lys Leu Trp Val Asp Gln Arg Arg Lys Leu Gly Ala Glu 
        915                 920                 925             


Asp Leu Arg Cys Tyr Val Asp Thr Leu Ala Glu Val Thr Arg His Arg 
    930                 935                 940                 


His Ala Ala Ala His Val Arg Leu Val Asp His Val Glu Leu His Arg 
945                 950                 955                 960 


Leu Met Leu Ala Val Leu Gly Arg Leu Leu Asp Phe Ala Gly Leu Phe 
                965                 970                 975     


Glu Arg Asp Leu Tyr Phe Ala Met Leu Ala Leu Ile Tyr Arg Ala Pro 
            980                 985                 990         


Ser Ser Pro Gln Ala Val Leu Asp  Glu Ala Asp Arg Glu  Leu Leu Arg 
        995                 1000                 1005             


Arg Gly  Gln Ile Val Glu Thr  Trp Arg Lys Leu Gln  Asp Ser Thr 
    1010                 1015                 1020             


Phe Lys  Asp Glu Leu Ala Gln  Leu Phe Asp Pro Thr  Ser Gly Arg 
    1025                 1030                 1035             


Val Ile  Arg Val Arg Asn Asp  Phe Ala His Phe Asn  Met Leu Asn 
    1040                 1045                 1050             


Pro Arg  Arg Ser Arg Gly Ala  Thr Ile Asp Leu Thr  Ala Arg Ser 
    1055                 1060                 1065             


Thr Pro  Pro Ala Asp 
    1070             


<210>  581
<211>  1315
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  581

Met Ala Glu Thr Leu Thr Phe Thr Asn Leu Tyr Asp Ile Leu Thr Leu 
1               5                   10                  15      


Ile Asp Ser Gly Leu Asn Leu His Ile Asn Leu Gly Val Ile Ile Met 
            20                  25                  30          


Lys Leu Thr Arg Arg Arg Ile Ser Gly Asn Ser Val Asp Gln Lys Ile 
        35                  40                  45              


Thr Ala Ala Phe Tyr Arg Asp Met Ser Gln Gly Leu Leu Tyr Tyr Asp 
    50                  55                  60                  


Ser Glu Asp Asn Asp Cys Thr Asp Lys Val Ile Glu Ser Met Asp Phe 
65                  70                  75                  80  


Glu Arg Ser Trp Arg Gly Arg Ile Leu Lys Asn Gly Glu Asp Asp Lys 
                85                  90                  95      


Asn Pro Phe Tyr Met Phe Val Lys Gly Leu Val Gly Ser Asn Asp Lys 
            100                 105                 110         


Ile Val Cys Glu Pro Ile Asp Val Asp Ser Asp Pro Asp Asn Leu Asp 
        115                 120                 125             


Ile Leu Ile Asn Lys Asn Leu Thr Gly Phe Gly Arg Asn Leu Lys Ala 
    130                 135                 140                 


Pro Asp Ser Asn Asp Thr Leu Glu Asn Leu Ile Arg Lys Ile Gln Ala 
145                 150                 155                 160 


Gly Ile Pro Glu Glu Glu Val Leu Pro Glu Leu Lys Lys Ile Lys Glu 
                165                 170                 175     


Met Ile Gln Lys Asp Ile Val Asn Arg Lys Glu Gln Leu Leu Lys Ser 
            180                 185                 190         


Ile Lys Asn Asn Arg Ile Pro Phe Ser Leu Glu Gly Ser Lys Leu Val 
        195                 200                 205             


Pro Ser Thr Lys Lys Met Lys Trp Leu Phe Lys Leu Ile Asp Val Pro 
    210                 215                 220                 


Asn Lys Thr Phe Asn Glu Lys Met Leu Glu Lys Tyr Trp Glu Ile Tyr 
225                 230                 235                 240 


Asp Tyr Asp Lys Leu Glu Ala Asn Ile Thr Asn Arg Leu Asp Lys Thr 
                245                 250                 255     


Asp Lys Asn Ala Arg Ser Ile Ser Arg Ala Val Ser Asp Glu Leu Arg 
            260                 265                 270         


Glu Tyr His Lys Tyr Leu Arg Thr Asn Tyr Asn Arg Phe Val Ser Gly 
        275                 280                 285             


Asp Arg Pro Ala Ala Gly Leu Asp Asn Gly Gly Ser Ala Lys Tyr Asn 
    290                 295                 300                 


Pro Asp Lys Glu Glu Phe Leu Leu Phe Leu Lys Glu Val Glu Gln Tyr 
305                 310                 315                 320 


Phe Lys Lys Tyr Phe Pro Val Lys Ser Lys His Ser Asn Lys Ser Lys 
                325                 330                 335     


Asp Lys Ser Leu Val Asp Lys Tyr Lys Asn Tyr Cys Ser Tyr Lys Val 
            340                 345                 350         


Val Lys Lys Glu Val Asn Arg Ser Ile Ile Asn Gln Leu Val Ala Gly 
        355                 360                 365             


Leu Ile Gln Gln Gly Lys Leu Leu Tyr Tyr Phe Tyr Tyr Asn Asp Thr 
    370                 375                 380                 


Trp Gln Glu Asp Phe Leu Asn Ser Tyr Gly Leu Ser Tyr Ile Gln Val 
385                 390                 395                 400 


Glu Glu Ala Phe Lys Lys Ser Val Met Thr Ser Leu Ser Trp Gly Ile 
                405                 410                 415     


Asn Arg Leu Thr Ser Phe Phe Ile Asp Asp Ser Asn Thr Val Lys Phe 
            420                 425                 430         


Asp Asp Ile Thr Thr Lys Arg Ala Lys Glu Ala Ile Glu Ser Asn Tyr 
        435                 440                 445             


Phe Asn Lys Leu Arg Thr Cys Ser Arg Met Gln Asp His Phe Lys Glu 
    450                 455                 460                 


Lys Leu Ala Phe Phe Tyr Pro Val Tyr Val Lys Asp Lys Lys Asp Arg 
465                 470                 475                 480 


Pro Asp Asp Ile Glu Lys Leu Ile Val Leu Val Lys Asn Ala Ile Glu 
                485                 490                 495     


Ser Val Ser Tyr Leu Arg Asn Arg Ile Phe His Phe Lys Lys Ser Ser 
            500                 505                 510         


Leu Leu Glu Leu Leu Lys Glu Leu Asp Asp Lys Asn Ser Gly Gln Asp 
        515                 520                 525             


Lys Ile Asp Tyr Ser Val Ala Ala Glu Phe Ile Lys Arg Asp Ile Glu 
    530                 535                 540                 


Asn Leu Tyr Asp Val Phe Arg Glu Gln Ile Arg Ser Leu Gly Ile Ala 
545                 550                 555                 560 


Glu Tyr Tyr Lys Ala Asp Met Ile Ser Asp Cys Phe Lys Thr Cys Gly 
                565                 570                 575     


Leu Glu Phe Ala Leu Tyr Ser Pro Lys Asn Ser Leu Met Pro Ala Phe 
            580                 585                 590         


Lys Asn Val Tyr Lys Arg Gly Ala Asn Leu Asn Lys Ala Tyr Ile Arg 
        595                 600                 605             


Asp Lys Gly Pro Lys Glu Thr Gly Asp Gln Gly Gln Asn Ser Tyr Lys 
    610                 615                 620                 


Ala Leu Glu Glu Tyr Arg Glu Leu Thr Trp Tyr Ile Glu Val Lys Asn 
625                 630                 635                 640 


Asn Asp Gln Ser Tyr Asn Ala Tyr Lys Asn Leu Leu Gln Leu Ile Tyr 
                645                 650                 655     


Tyr His Ala Phe Leu Pro Glu Val Arg Glu Asn Glu Ala Leu Ile Thr 
            660                 665                 670         


Asp Phe Ile Asn Arg Thr Lys Glu Trp Asn Arg Lys Glu Thr Glu Glu 
        675                 680                 685             


Arg Leu Asn Thr Lys Asn Asn Lys Lys His Lys Asn Phe Asp Glu Asn 
    690                 695                 700                 


Asp Asp Ile Thr Val Asn Thr Tyr Arg Tyr Glu Ser Ile Pro Asp Tyr 
705                 710                 715                 720 


Gln Gly Glu Ser Leu Asp Asp Tyr Leu Lys Val Leu Gln Arg Lys Gln 
                725                 730                 735     


Met Ala Arg Ala Lys Glu Val Asn Glu Lys Glu Glu Gly Asn Asn Asn 
            740                 745                 750         


Tyr Ile Gln Phe Ile Arg Asp Val Val Val Trp Ala Phe Gly Ala Tyr 
        755                 760                 765             


Leu Glu Asn Lys Leu Lys Asn Tyr Lys Asn Glu Leu Gln Pro Pro Leu 
    770                 775                 780                 


Ser Lys Glu Asn Ile Gly Leu Asn Asp Thr Leu Lys Glu Leu Phe Pro 
785                 790                 795                 800 


Glu Glu Lys Val Lys Ser Pro Phe Asn Ile Lys Cys Arg Phe Ser Ile 
                805                 810                 815     


Ser Thr Phe Ile Asp Asn Lys Gly Lys Ser Thr Asp Asn Thr Ser Ala 
            820                 825                 830         


Glu Ala Val Lys Thr Asp Gly Lys Glu Asp Glu Lys Asp Lys Lys Asn 
        835                 840                 845             


Ile Lys Arg Lys Asp Leu Leu Cys Phe Tyr Leu Phe Leu Arg Leu Leu 
    850                 855                 860                 


Asp Glu Asn Glu Ile Cys Lys Leu Gln His Gln Phe Ile Lys Tyr Arg 
865                 870                 875                 880 


Cys Ser Leu Lys Glu Arg Arg Phe Pro Gly Asn Arg Thr Glu Leu Glu 
                885                 890                 895     


Lys Glu Thr Glu Leu Leu Ala Glu Leu Glu Glu Leu Met Glu Leu Val 
            900                 905                 910         


Arg Phe Thr Met Pro Ser Ile Pro Glu Ile Ser Ala Lys Ala Glu Ser 
        915                 920                 925             


Gly Tyr Asp Thr Met Ile Lys Lys Tyr Phe Lys Asp Phe Ile Glu Lys 
    930                 935                 940                 


Lys Val Phe Lys Asn Pro Lys Thr Ser Asn Leu Tyr Tyr His Ser Asp 
945                 950                 955                 960 


Ser Lys Thr Pro Val Thr Arg Lys Tyr Met Ala Leu Leu Met Arg Ser 
                965                 970                 975     


Ala Pro Leu His Leu Tyr Lys Asp Ile Phe Lys Gly Tyr Tyr Leu Ile 
            980                 985                 990         


Thr Lys Lys Glu Cys Leu Glu Tyr  Ile Lys Leu Ser Asn  Ile Ile Lys 
        995                 1000                 1005             


Asp Tyr  Gln Asn Ser Leu Asn  Glu Leu His Glu Gln  Leu Glu Arg 
    1010                 1015                 1020             


Ile Lys  Leu Lys Ser Glu Lys  Gln Asn Gly Lys Asp  Ser Leu Tyr 
    1025                 1030                 1035             


Leu Asp  Lys Lys Asp Phe Tyr  Lys Val Lys Glu Tyr  Val Glu Asn 
    1040                 1045                 1050             


Leu Glu  Gln Val Ala Arg Tyr  Lys His Leu Gln His  Lys Ile Asn 
    1055                 1060                 1065             


Phe Glu  Thr Leu Tyr Arg Ile  Phe Arg Ile His Val  Asp Ile Ala 
    1070                 1075                 1080             


Ala Arg  Met Val Gly Tyr Thr  Gln Asp Trp Glu Arg  Asp Met His 
    1085                 1090                 1095             


Phe Leu  Phe Lys Ala Leu Val  Tyr Asn Gly Val Leu  Glu Glu Arg 
    1100                 1105                 1110             


Arg Phe  Glu Ala Ile Phe Asn  Asn Asn Asp Asp Asn  Asn Asp Gly 
    1115                 1120                 1125             


Arg Ile  Val Lys Lys Ile Gln  Asn Asn Leu Asn Asn  Lys Asn Arg 
    1130                 1135                 1140             


Glu Leu  Val Ser Met Leu Cys  Trp Asn Lys Lys Leu  Asn Lys Asn 
    1145                 1150                 1155             


Glu Phe  Gly Ala Ile Ile Trp  Lys Arg Asn Pro Ile  Ala His Leu 
    1160                 1165                 1170             


Asn His  Phe Thr Gln Thr Glu  Gln Asn Ser Lys Ser  Ser Leu Glu 
    1175                 1180                 1185             


Ser Leu  Ile Asn Ser Leu Arg  Ile Leu Leu Ala Tyr  Asp Arg Lys 
    1190                 1195                 1200             


Arg Gln  Asn Ala Val Thr Lys  Thr Ile Asn Asp Leu  Leu Leu Asn 
    1205                 1210                 1215             


Asp Tyr  His Ile Arg Ile Lys  Trp Glu Gly Arg Val  Asp Glu Gly 
    1220                 1225                 1230             


Gln Ile  Tyr Phe Asn Ile Lys  Glu Lys Glu Asp Ile  Glu Asn Glu 
    1235                 1240                 1245             


Pro Ile  Ile His Leu Lys His  Leu His Lys Lys Asp  Cys Tyr Ile 
    1250                 1255                 1260             


Tyr Lys  Asn Ser Tyr Met Phe  Asp Lys Gln Lys Glu  Trp Ile Cys 
    1265                 1270                 1275             


Asn Gly  Ile Lys Glu Glu Val  Tyr Asp Lys Ser Ile  Leu Lys Cys 
    1280                 1285                 1290             


Ile Gly  Asn Leu Phe Lys Phe  Asp Tyr Glu Asp Lys  Asn Lys Ser 
    1295                 1300                 1305             


Ser Ala  Asn Pro Lys His Thr  
    1310                 1315 


<210>  582
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  582

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Thr Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Asp Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Ser Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val His Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1400                 1405                 1410         


<210>  583
<211>  1287
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  583

Met Arg Ile Gly Lys Val Gln Gly Arg Thr Phe Thr Gly Phe Asp Asn 
1               5                   10                  15      


Ala Arg Gly Lys Thr Leu Arg Arg Arg Leu Leu Thr Arg Pro Asp Asn 
            20                  25                  30          


Glu Ala Arg Ser Leu Ser Glu His Leu Ala His Asp Pro Lys Ala Leu 
        35                  40                  45              


Ile Gly Gln Ala Ile Ser Arg Ile Asp Thr Ile Tyr Gln Lys Pro Lys 
    50                  55                  60                  


Thr Gly Lys Pro Thr Pro Glu Gln Phe Gly His Arg Asp Thr Leu Gly 
65                  70                  75                  80  


Trp Ala Tyr Trp Lys Leu Leu Val Ala Ser Tyr Pro Glu Val Glu Gly 
                85                  90                  95      


His Arg Asp Leu Phe Val Arg Arg Leu His Pro Tyr Gly Asp Thr Pro 
            100                 105                 110         


Pro Lys Ser His Gly Gln Lys Glu Gly Glu His Gln Lys Gly Gly Lys 
        115                 120                 125             


Pro Gln Leu Glu Gly Arg Trp His Gly Val Met Ala Gln His Gly Lys 
    130                 135                 140                 


Asn Pro Asp Gln Ile Ala Ala Arg Leu Phe Asp His Leu His Asn Ser 
145                 150                 155                 160 


Glu Leu Arg Phe Gly Gly Thr Ala Ser Gly Glu Pro Arg Thr Arg Pro 
                165                 170                 175     


Gly Lys Glu Ala Thr Pro Thr Gly Leu Ile Gly Ala Arg Ala Lys Thr 
            180                 185                 190         


Ile Glu His Ser Val Leu Pro Arg Asp Ala Lys Arg Phe Val Ala Glu 
        195                 200                 205             


Trp Arg Gly Glu Asp Gln Glu Arg Tyr Ala Gly Ala Arg Asp Ile Ala 
    210                 215                 220                 


Ala Ala Ile Ser Ala Gly Leu Asn Asp Lys Asp Gln Lys Ser Gly Ser 
225                 230                 235                 240 


Gly Arg Lys Ser Ala Val Ile Gly Lys Leu Leu Ser Asp His Leu Glu 
                245                 250                 255     


Thr Leu Thr Gly Asn Arg Lys Cys Arg Phe Asp Pro Lys Ser Thr Ala 
            260                 265                 270         


Glu Thr Leu Glu Leu Arg Asp Gly Glu Ser Val Asp Asp Arg Arg Arg 
        275                 280                 285             


Ile Leu Glu Leu His Ala Glu Val Lys Ala Thr Tyr Lys Arg Met Ala 
    290                 295                 300                 


Ala Trp Lys Pro Ala Lys Leu Pro Arg Asn Ser Asp Glu Leu Phe Arg 
305                 310                 315                 320 


Leu Val Arg Gln Gln Ala Asp Asn Arg Ile Leu Asn His Leu Val Arg 
                325                 330                 335     


Val Gly Arg Ile Ser Val Tyr Ser Glu Gln Ser Asp Ala Leu Ser Glu 
            340                 345                 350         


Ser Gln Phe Trp Thr Ser Gly Gly Gln Thr Gln Ile Lys Glu Ser Glu 
        355                 360                 365             


Val Phe Ala Arg Leu Trp Ile Gly Ala Ile Ser Arg Ala Ser Tyr Ser 
    370                 375                 380                 


Met Lys Ala Trp Leu Glu Pro Glu Gly Thr Val Phe Asn Pro Ser Ile 
385                 390                 395                 400 


Asn Asp Phe Asp Val Thr Ser Ser His Asn Thr Asn Arg Ile Leu Glu 
                405                 410                 415     


Asp Ser Gly Arg Leu Ser Asn Ala Met Ala Arg Arg Ala Ile Tyr Phe 
            420                 425                 430         


Gly Glu Thr Pro Glu Phe Asp Ala Leu Gly Glu Glu Asp Gln Arg Val 
        435                 440                 445             


Leu Val Lys Lys Cys Leu Asp Ala Leu Ser Ala Cys Arg Asn Arg Thr 
    450                 455                 460                 


Phe His His Gly Gln Arg Ala Lys Phe Leu Lys Glu Val Arg Lys Gly 
465                 470                 475                 480 


Leu Lys Glu Lys Glu Ala Asp Ser Ala Gly Pro Ala Ala Trp Glu Gly 
                485                 490                 495     


Ile Arg Glu Val Ile Gln Ala Asp Ala Arg Asn Leu Gly Ala Arg Leu 
            500                 505                 510         


Leu Gln Asp Leu Thr Gly Ala Lys Val His Ser Phe Ala Thr Asp Pro 
        515                 520                 525             


Glu Phe Arg His Leu Tyr Glu Ser Val Ala Ala Thr Leu Thr Ala Gly 
    530                 535                 540                 


Gly Glu Leu Glu Ala Ala Leu Pro Arg Leu Lys Asn Val Leu Lys Arg 
545                 550                 555                 560 


Ala Glu Gly Val Arg Cys Tyr Leu Asp Thr Pro Ser Gln Arg Arg Glu 
                565                 570                 575     


Gly Asp Glu Ser Leu Ile Ala Arg Leu Pro Val Ala Pro Val Pro Arg 
            580                 585                 590         


Glu Leu Asp Asp Ala Ala Thr Lys Ala Arg His Ser Ala Leu Leu Arg 
        595                 600                 605             


Leu Tyr Asp Gly Pro Phe Arg Pro Trp Ala Thr Glu Leu Arg Gly Glu 
    610                 615                 620                 


Arg Leu Ser Asp Tyr Ala Ala Arg Ala Lys Arg Leu Ala Thr Arg Leu 
625                 630                 635                 640 


Ala Lys Ser Thr Asn Thr Ala Ser Pro Tyr Pro Asp Ser Val Glu Gly 
                645                 650                 655     


Arg Ser Val Arg Leu Arg Asp Pro Ile Thr Ala Asp Thr Ala Pro Glu 
            660                 665                 670         


Thr Leu Lys Thr Tyr Leu Ser Ala Leu Thr Ala Glu Thr Ala Thr Glu 
        675                 680                 685             


Phe Arg Val Gln Lys Gly Tyr Glu Ser Asp Gly Glu Lys Ala Lys Glu 
    690                 695                 700                 


Gln Ala Glu Phe Ile Glu Asp Phe Arg Arg Asp Met Ile Ala Leu Ala 
705                 710                 715                 720 


Phe Gln Asp Phe Ile Arg Asp His Gly Phe Ala Trp Leu Leu Asp Ile 
                725                 730                 735     


Ala Ser Lys Ala Glu Pro Ser Asn Asp Ala Pro Asn Leu Pro Asp Pro 
            740                 745                 750         


Val Asp Thr Gly Lys Asp Thr Val Phe Glu Asp Trp Gln Ala Leu Leu 
        755                 760                 765             


Tyr Leu Phe Leu His Phe Val Pro Ala Asp Asp Val Ser Gln Leu Leu 
    770                 775                 780                 


His Gln Leu Arg Lys Trp Asp Ala Leu Gln Asp Lys Tyr Glu Leu Ala 
785                 790                 795                 800 


Glu Pro Gly Glu Thr Leu Gly Gln Thr Lys Ala Asp Thr Arg Lys Ile 
                805                 810                 815     


Val Gly Gln Phe Arg Asp Cys Leu Thr Leu Phe Leu Lys Thr Gly Asp 
            820                 825                 830         


Ala Arg Phe Asp Gly Glu Gly Val Glu Leu Pro Leu Ser Asp Phe Gln 
        835                 840                 845             


Glu Leu Phe Glu Ser Pro Ala Thr Phe Lys Glu Leu Phe Leu Ala Glu 
    850                 855                 860                 


Pro Ala Glu Asn Asp Ala Ser Glu Thr Asp Asp Gln Asp Ala Pro Gly 
865                 870                 875                 880 


Glu Lys His Arg Val Thr Arg Thr Arg Arg Gly Leu Arg Gln Ile Leu 
                885                 890                 895     


Arg Tyr Asn His Met Pro Val Leu Arg Asp Leu Phe Leu Ala His Lys 
            900                 905                 910         


Val Thr Asp Ala Glu Val Asp Gly Leu Gln Ala Leu Glu Val Asp Asp 
        915                 920                 925             


Pro Gln Thr Gly Glu Ser Gln Ile Gly Ala Ala Gln Arg Ile Arg Thr 
    930                 935                 940                 


Glu Ile His His His Thr Ser Asn Asp Lys Gln Ile Ser Glu Ala Lys 
945                 950                 955                 960 


Val Glu Glu Tyr Arg Arg Ala Leu Ser Thr Ile Glu Arg His Arg Phe 
                965                 970                 975     


Leu Val Gly Arg Val Tyr Leu Gly Asp His Ile Arg Val His Lys Leu 
            980                 985                 990         


Met Met Asp Val Met Gly Arg Leu  Val Asp Phe Ala Gly  Ala Trp Glu 
        995                 1000                 1005             


Arg Glu  Ala Ala Asp Gly Asp  Arg Lys Gly Phe Ile  Ser Arg Ala 
    1010                 1015                 1020             


Ile Ala  Leu Pro Glu Val Ala  Glu Gly Tyr Ala Ala  Asp Arg Leu 
    1025                 1030                 1035             


Lys Thr  Val Ala Arg Arg Val  Leu Asp Asp Gly Glu  Ala Arg Arg 
    1040                 1045                 1050             


Ile Arg  Asn Asp Leu Gly His  Phe Asn Asp Leu Ala  Pro Thr Ser 
    1055                 1060                 1065             


Gly Pro  Ala Asn Leu Thr Phe  Val Val Asn Arg Ala  Arg Arg Met 
    1070                 1075                 1080             


Met Arg  His Asp Arg Lys Arg  Lys Asn Ala Val Thr  Lys Ser Val 
    1085                 1090                 1095             


Ile Glu  Ile Leu Asn Arg Gln  Gly Leu Gly Ile Glu  Trp Thr Met 
    1100                 1105                 1110             


Arg Asn  His Glu Leu Cys Glu  Ala Lys Leu Trp Gln  Asn Pro Val 
    1115                 1120                 1125             


Lys His  Leu Gly Phe Ala Thr  Leu Glu Gly Arg Gly  Lys Lys Trp 
    1130                 1135                 1140             


Arg Arg  Pro Phe Glu Ala Arg  Tyr Gly Asp Ala Tyr  Met Ala Met 
    1145                 1150                 1155             


Val Ala  Gln Leu Phe Asp Gly  Thr Val Thr Ser Pro  Pro Ala Lys 
    1160                 1165                 1170             


Gly Pro  Pro Gln Ser Gly Lys  Ser Gly Gly Lys Pro  Gly Lys Gly 
    1175                 1180                 1185             


Ala Glu  Gly Gly Ala Lys Glu  Lys Ser Arg Ser Pro  Thr Arg Met 
    1190                 1195                 1200             


Glu Glu  Gly Gly Val Tyr Glu  Gly Arg Val Ala Lys  Ala Lys Ser 
    1205                 1210                 1215             


Asp Lys  Gly Phe Gly Phe Leu  Leu Val Glu Gly Ala  Gln Glu Glu 
    1220                 1225                 1230             


Ile Phe  Leu His Ile Tyr Gly  Ile Ser Gly Asn Arg  Pro Ala Arg 
    1235                 1240                 1245             


Ile Glu  Asn Gly Gln Arg Tyr  Arg Phe Thr Leu Gly  Ile Asp Arg 
    1250                 1255                 1260             


Asp Arg  Glu Arg Arg Lys Glu  Arg Ala Trp Val Ala  Arg Glu Ala 
    1265                 1270                 1275             


Val Arg  Ile Asp Glu Asn Arg  Ser Lys 
    1280                 1285         


<210>  584
<211>  1373
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  584

Met Ala Lys His Leu Arg Pro Ile Gly Glu Ser Tyr Thr Asp Phe Leu 
1               5                   10                  15      


Asp Glu Thr Glu Phe Val Arg Leu Gly Arg Gly Leu His Arg Gly His 
            20                  25                  30          


His Gly Val Gln Ile Pro Pro Thr Glu Leu Pro Ser Tyr Leu Ala Glu 
        35                  40                  45              


Tyr Arg Lys Ala Leu Met Arg Gln Val Val Ala Val Leu Asp Lys Val 
    50                  55                  60                  


Val Gly Lys Arg Arg Arg Leu Ser Gly Met His Pro Glu Ala Tyr Arg 
65                  70                  75                  80  


Asp Arg Val His Leu Ala Glu Ala Leu Trp Val Arg Leu Val Ala Arg 
                85                  90                  95      


Val Lys Glu Ile Gly Thr Pro Pro Asp Pro Ser Glu Leu Leu Asp Leu 
            100                 105                 110         


Arg Arg Met Trp Asn Ala Lys Ala His Pro Tyr Ala Glu Tyr Asp Val 
        115                 120                 125             


Val Pro Arg Ala Pro Leu Asn Asp Gly Asn Gly Gln Lys Ile Leu Glu 
    130                 135                 140                 


Cys Arg Glu Val Asp Asp Pro Lys Ile Glu Arg Ser Asp Phe Glu Gly 
145                 150                 155                 160 


Arg Trp His Gly Arg Phe Trp Gln Ser Glu Pro Gly Pro Val Asp Tyr 
                165                 170                 175     


Asn Ala Ile Ala Asp Arg Ile Phe Ala His Leu Phe Asp Gln Glu Ala 
            180                 185                 190         


Val Ile Gly Gly Gly Pro Arg Arg Glu Gly Asn Val Thr Val Pro Asp 
        195                 200                 205             


Glu Asp Ile Asn Gly Gln Pro Gly Pro Ala Thr Gly Lys Gly Leu Ile 
    210                 215                 220                 


Ile Ala Arg Gly Gln Ser Ile Val Lys Ser Ala Ser Asp Pro Arg Arg 
225                 230                 235                 240 


Ser Ser Lys Lys Val Gln Arg Thr Trp Asp Lys Ala Val Glu Arg Arg 
                245                 250                 255     


Tyr Phe Gly Asp Asp Gly Lys Gly Gly Ser Asp Ile Ala Lys Ala Ile 
            260                 265                 270         


Tyr Glu Glu Leu Gly Asp Pro Ala Thr Leu Ala Asp Pro Ile Tyr Ala 
        275                 280                 285             


Ser Trp Phe Gly Ser Arg Leu Tyr Asp His Phe Gly Ser Phe Lys Asn 
    290                 295                 300                 


Ser Leu Pro Leu Glu Leu Lys Asp Pro Phe Lys Glu Gln Ile Trp Ala 
305                 310                 315                 320 


Leu His Asn Ser Val Arg Gln Phe Tyr Gln Arg Met Ala Lys Ser Asp 
                325                 330                 335     


Arg Phe Arg Leu Ala Leu Gln Asn Ala Arg Ser Glu Val Pro Asp Arg 
            340                 345                 350         


Ser Glu Leu Leu Ala Leu Leu Pro Lys Asp His Asp His Leu Leu Leu 
        355                 360                 365             


Val Leu Gly Gly Lys Lys Lys Asn Ala Glu Met Ser Glu Leu Ile Arg 
    370                 375                 380                 


Leu Gly Lys Leu Phe Val His Ala Ser Asp Val Leu His Asp Phe Asp 
385                 390                 395                 400 


Ala Asn Asp Ala Ala Ala Leu Asp Ala Phe Lys Arg Arg Met Ser Phe 
                405                 410                 415     


Leu Ala Thr Ser Ile Gly Gln Ser Glu Ile Lys Gln Thr Glu Thr Phe 
            420                 425                 430         


Ala Arg Thr Trp Arg Gly Ala Val Gly Leu Thr Leu Arg Thr Val Lys 
        435                 440                 445             


Gly Leu Ala Asp Pro Arg Gly Ile Ile Gly Thr Pro Asp Asn Arg Asp 
    450                 455                 460                 


Leu Gly Thr Ala Gly Pro Met Lys Asp Ala Phe Asn Lys Phe Asp Gln 
465                 470                 475                 480 


Pro His Phe Gln Gln His Met Thr Ile Ile Phe Gly Asn Lys Glu Leu 
                485                 490                 495     


Gln Ala Glu Gly Asn Pro Thr Arg Ser Ser Val Phe Thr Ala Asn Gly 
            500                 505                 510         


Asp Lys Asp His Gln Ala Glu Leu Leu Trp Gly Phe Leu Cys Val Val 
        515                 520                 525             


Arg Ser Val Arg Asn Arg Thr Asn His Tyr Asn Val Arg Arg Ala Leu 
    530                 535                 540                 


Leu Arg Leu Leu Asp Glu Gly Ile Val Ser Pro Met Pro Ser Asp Pro 
545                 550                 555                 560 


Lys Lys Glu Arg Val Glu Asn Arg Asn Leu Cys Thr Val Ser Pro Thr 
                565                 570                 575     


Ala Leu Glu Ala Phe Arg Arg Leu Leu Asn Phe Asp Leu Ala Ile Gln 
            580                 585                 590         


Lys Glu Ala Val Arg Thr Ala Leu Glu Gln Ala Lys Ala Ser Glu Phe 
        595                 600                 605             


Val Glu Glu Gly Lys Leu Arg Gly Leu Val Ser Glu Leu Ala Gly Thr 
    610                 615                 620                 


Glu Asp Met Pro Ala Leu His Ile Pro Arg Phe Ser Ala Val Met Asp 
625                 630                 635                 640 


Lys Val Arg Arg Leu Ala Asp Asn Arg Asp Val Gly Leu Asp Pro Ile 
                645                 650                 655     


Leu Ser Thr Leu Gln Arg Ser Leu Pro Pro Thr Asp Lys Gln Ala Glu 
            660                 665                 670         


Ser Asp Ala Ala Arg Cys Arg Tyr Arg Leu Leu Leu Glu Leu Tyr Lys 
        675                 680                 685             


Ser Gly Phe Arg Ser Trp Phe Ser Gly Ile Gln Ser Asn Glu Glu Asn 
    690                 695                 700                 


Asn Arg Glu Ile Cys His Trp Ala Val Lys Gln Val Gly Arg Ala Lys 
705                 710                 715                 720 


Asp Ala Arg Lys Ser Glu Tyr Asp Lys Lys Thr Lys Arg His Tyr Arg 
                725                 730                 735     


Ser Pro Asn Ser Leu Ile Asp Asp Leu Gly Leu Asp Lys Phe Asp Asp 
            740                 745                 750         


Leu Thr Asp Leu Leu Glu Ala Leu Ala Ser Gln Ser Thr Arg Glu His 
        755                 760                 765             


Asp Gln Asn Leu Lys Tyr Val Pro Asp Ala Arg Val Gln Ser Gln Met 
    770                 775                 780                 


Ser Asn Arg Ile Glu Glu Phe Arg Gln Glu Leu Phe Ala His Ile Phe 
785                 790                 795                 800 


Thr Lys Tyr Leu Asp Thr His Asp Phe Gly Trp Ile Gly Ala Ile Glu 
                805                 810                 815     


Val Arg Arg Glu Ala Cys Asp Leu Ala Asp Val Val Ser Ala Phe Glu 
            820                 825                 830         


Val Arg Asp Gln Lys Phe Asp Ala Asp Trp His Ser Gln Phe Tyr Ala 
        835                 840                 845             


Trp Leu Tyr Met Val Pro Pro Ile Glu Ala Ser Arg Leu Arg His Gln 
    850                 855                 860                 


Met Arg Lys Ser Ala Val Met Asp Asp Lys Trp Ser Thr Thr Leu Glu 
865                 870                 875                 880 


Leu Thr Ser Gly Asp Arg Lys Thr Arg Asp Asp His Ala Gln Asp Val 
                885                 890                 895     


Leu Ala Asp Met Asp Arg Leu Phe Ser Leu Tyr Thr Lys Val Gln Ala 
            900                 905                 910         


Ala Gly Phe Asn Gly Gln Glu His Glu Ser Ala Leu Gly Ser Lys Ser 
        915                 920                 925             


Leu Phe Tyr Glu Asp Gly Asn Gln Phe Asp Glu Val Tyr Ser Pro Asp 
    930                 935                 940                 


Thr Glu Thr His Asn Lys Thr Phe Pro Gly Thr Arg Arg Gly Leu Arg 
945                 950                 955                 960 


Gln Leu Val Arg Tyr Ala His Leu Pro Ala Leu Glu Gly Val Phe Lys 
                965                 970                 975     


Lys His Arg Ile Thr Lys Ala Glu Val Glu Thr Phe Val Ala Leu Tyr 
            980                 985                 990         


Asp Glu Asn Arg Arg Asp Pro Gly  Ser Val Ala His Met  Leu Arg Arg 
        995                 1000                 1005             


Glu Lys  Leu Arg Thr Glu Ile  Leu Arg Ser Ile His  Asp Gly Pro 
    1010                 1015                 1020             


Lys Pro  Lys Asp Lys Asp Phe  Trp Pro Lys Leu Glu  Ala Lys Cys 
    1025                 1030                 1035             


Leu Glu  Tyr Arg Thr Val Ala  Thr Glu Thr Ala Ile  Tyr Asn Phe 
    1040                 1045                 1050             


Gln Ala  Asn Ala Ala Arg Leu  Asn Asp His Ala Arg  Leu His Gln 
    1055                 1060                 1065             


Ile Val  Met Arg Val Val Ala  Arg Leu Thr Asp Tyr  Ala Leu Ile 
    1070                 1075                 1080             


Trp Glu  Arg Asp Arg Leu Phe  Ala Phe Val Gly Met  Leu Tyr Arg 
    1085                 1090                 1095             


Gln Thr  Gly Gly Thr Gly Ile  Asn Pro Ala Met Arg  His Ala Glu 
    1100                 1105                 1110             


Lys Thr  Asn Ala Pro Pro Arg  Ile Gly Ile Leu Val  Ser Asp Ser 
    1115                 1120                 1125             


Ala Leu  Ala Lys Lys Leu Asn  Ser Asn Ser Ala Glu  Val Phe Ile 
    1130                 1135                 1140             


Pro Tyr  Leu Asp Thr Glu Thr  Gly Phe Asp Ala Pro  Arg Phe Asp 
    1145                 1150                 1155             


Asp Leu  Cys Thr Leu Leu Ser  His Glu His Ala Lys  Glu Phe Arg 
    1160                 1165                 1170             


Phe His  Phe Leu Glu Val Gly  Glu Glu Asn Ser Lys  Asp Glu Ala 
    1175                 1180                 1185             


Arg Arg  Leu Asn Glu Glu Thr  Met Gly His Arg Lys  Arg Pro Ala 
    1190                 1195                 1200             


Phe Lys  Arg Gly Thr Arg Arg  Gln Gly Ile Arg Asn  Asp Leu Ala 
    1205                 1210                 1215             


His His  Asn Val Leu Asp Leu  Ala Gly Gly Ala Gly  Pro Asn Leu 
    1220                 1225                 1230             


Thr Tyr  Val Val Asn Ala Val  Arg Ser Leu Leu Ser  Tyr Asp Arg 
    1235                 1240                 1245             


Lys Leu  Lys Asn Ala Val Pro  Lys Ser Ile Lys Arg  Ile Leu Gly 
    1250                 1255                 1260             


Glu Glu  Gly Leu Ile Ile Glu  Trp Gln Met Asn Tyr  Asp Arg Leu 
    1265                 1270                 1275             


Lys Lys  Pro Thr Val Tyr Pro  Asn Val Glu Thr His  Leu Thr Met 
    1280                 1285                 1290             


Val Pro  Pro Arg His Met Thr  Ala Pro Val Ser Phe  Thr Leu Pro 
    1295                 1300                 1305             


Arg Ala  Ser Val Arg Leu Ala  Ser Met Val Lys Ala  Val Phe Asp 
    1310                 1315                 1320             


Phe Gly  Ser Ser Gly Tyr Gly  Glu Glu Arg Met Ile  Gly Gly Arg 
    1325                 1330                 1335             


Thr Ala  Lys Gln Ala Val Tyr  Pro Asp Asp Phe Thr  Arg Arg Phe 
    1340                 1345                 1350             


Pro Gln  Thr Pro Met Gly Leu  Lys Gln Ala Thr Arg  Leu Val Phe 
    1355                 1360                 1365             


Ala Ser  Glu Asn Ser 
    1370             


<210>  585
<211>  1197
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  585

Met Lys Val Thr Lys Ile Asp Gly Ile Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Arg Tyr Thr Gly Asn Phe Asn Ile Lys Asn Glu 
            20                  25                  30          


Met Lys Glu Arg Leu Glu Lys Leu Lys Glu Leu Lys Leu Ser Asn Tyr 
        35                  40                  45              


Val Lys Asn Pro Glu Asn Val Lys Asn Lys Asp Lys Asn Lys Glu Lys 
    50                  55                  60                  


Glu Thr Lys Ser Arg Arg Glu Asn Leu Lys Lys Tyr Phe Ser Glu Ile 
65                  70                  75                  80  


Ile Leu Arg Lys Lys Glu Glu Lys Tyr Leu Leu Lys Lys Thr Arg Lys 
                85                  90                  95      


Phe Lys Asn Ile Thr Glu Glu Ile Asn Tyr Asp Asp Ile Lys Lys Arg 
            100                 105                 110         


Glu Asn Gln Gln Lys Ile Phe Asp Val Leu Lys Glu Leu Leu Glu Gln 
        115                 120                 125             


Arg Ile Asn Glu Asn Asp Lys Glu Glu Ile Leu Asn Phe Asp Ser Val 
    130                 135                 140                 


Lys Leu Lys Glu Val Phe Gly Glu Asp Phe Ile Lys Lys Glu Ser Lys 
145                 150                 155                 160 


Ile Lys Ala Ile Glu Glu Ser Leu Glu Lys Asn Arg Ala Asp Tyr Arg 
                165                 170                 175     


Lys Asp Tyr Val Glu Leu Glu Asn Glu Lys Tyr Glu Asp Val Lys Gly 
            180                 185                 190         


Gln Asn Lys Arg Ser Leu Val Phe Glu Tyr Tyr Lys Asn Pro Glu Asn 
        195                 200                 205             


Arg Glu Lys Phe Lys Glu Asn Ile Lys Tyr Ala Phe Glu Asn Leu Tyr 
    210                 215                 220                 


Thr Glu Glu Asn Ile Lys Asn Leu Tyr Ser Glu Ile Glu Glu Ile Phe 
225                 230                 235                 240 


Gly Lys Val His Leu Lys Ser Lys Val Arg Asp Phe Tyr Gln Asn Arg 
                245                 250                 255     


Ile Ile Gly Glu Ser Glu Phe Ser Glu Lys Asp Glu Glu Gly Ile Ser 
            260                 265                 270         


Ile Leu Tyr Lys Gln Ile Ile Asn Ser Val Glu Lys Lys Glu Lys Phe 
        275                 280                 285             


Val Glu Phe Leu Gln Lys Val Lys Ile Lys Asp Leu Thr Arg Ser Gln 
    290                 295                 300                 


Ile Phe Tyr Lys Tyr Phe Leu Glu Asn Glu Glu Leu Asn Asp Glu Asn 
305                 310                 315                 320 


Ile Lys Tyr Val Phe Ser Tyr Phe Val Glu Ile Glu Val Asn Lys Leu 
                325                 330                 335     


Leu Lys Glu Asn Val Tyr Lys Thr Lys Lys Phe Asn Glu Gly Asn Lys 
            340                 345                 350         


Tyr Arg Val Lys Asn Ile Phe Asn Tyr Asp Lys Leu Lys Asn Leu Val 
        355                 360                 365             


Val Tyr Lys Leu Glu Asn Lys Leu Asn Asn Tyr Ile Arg Asn Cys Gly 
    370                 375                 380                 


Lys Tyr Asn Tyr His Met Glu Asn Gly Cys Val Ala Thr Ser Asp Thr 
385                 390                 395                 400 


Asn Met Lys Asn Arg Gln Thr Glu Ala Phe Leu Arg Ser Ile Leu Gly 
                405                 410                 415     


Val Ser Ser Phe Gly Tyr Phe Ser Leu Arg Asn Ile Leu Gly Val Asn 
            420                 425                 430         


Asp Asn Asp Phe Tyr Glu Ile Glu Glu Glu Leu Thr Glu Asp Glu Arg 
        435                 440                 445             


Lys Asn Glu Asn Phe Ile Leu Lys Lys Ala Lys Glu Asp Ile Thr Ser 
    450                 455                 460                 


Lys Asn Ile Phe Glu Lys Val Val Asp Lys Ser Phe Glu Lys Lys Gly 
465                 470                 475                 480 


Ile Tyr Gln Ile Lys Glu Asn Leu Lys Met Phe Tyr Gly Asn Ser Phe 
                485                 490                 495     


Asp Lys Val Asp Lys Asp Glu Leu Lys Lys Phe Phe Val Asn Met Leu 
            500                 505                 510         


Glu Ala Ile Thr Ser Val Arg His Arg Ile Val His Tyr Asn Ile Asn 
        515                 520                 525             


Thr Asn Ser Glu Asn Ile Phe Asp Phe Ser Asn Ile Glu Val Ser Lys 
    530                 535                 540                 


Leu Leu Lys Asn Ile Phe Glu Lys Glu Ile Asp Thr Arg Glu Leu Lys 
545                 550                 555                 560 


Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Gly Val Phe Asp Tyr Trp 
                565                 570                 575     


Glu Ser Trp Lys Ile Lys Lys Tyr Leu Glu Asn Ile Glu Phe Lys Phe 
            580                 585                 590         


Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys Leu Tyr Asn 
        595                 600                 605             


Arg Ile Asp Asn Leu Lys Gly Asn Asn Ala Leu Asn Leu Gly Tyr Ile 
    610                 615                 620                 


Asn Ile Pro Lys Arg Lys Glu Ala Lys Asp Ser Gln Ile Tyr Leu Leu 
625                 630                 635                 640 


Lys Asn Ile Tyr Tyr Gly Glu Phe Val Glu Lys Phe Val Asn Asp Asn 
                645                 650                 655     


Lys Asn Phe Glu Lys Ile Val Lys Glu Ile Ile Glu Ile Asn Arg Gly 
            660                 665                 670         


Ala Gly Thr Asn Lys Lys Thr Gly Phe Tyr Lys Leu Glu Lys Phe Glu 
        675                 680                 685             


Thr Leu Lys Ala Asn Thr Pro Ile Glu Tyr Leu Glu Lys Leu Gln Ser 
    690                 695                 700                 


Leu His Lys Ile Ser Tyr Asp Lys Glu Lys Ile Glu Glu Asp Lys Asp 
705                 710                 715                 720 


Ile Tyr Val Asp Phe Val Gln Lys Ile Phe Leu Lys Gly Phe Val Asn 
                725                 730                 735     


Tyr Leu Lys Lys Leu Asp Ser Leu Lys Ser Leu Asn Leu Leu Asn Leu 
            740                 745                 750         


Arg Lys Asp Glu Thr Ile Thr Asp Lys Lys Ser Phe His Asp Glu Lys 
        755                 760                 765             


Leu Lys Leu Trp Glu Asn Ser Gly Ser Asn Leu Ser Lys Met Pro Glu 
    770                 775                 780                 


Glu Ile Tyr Glu Tyr Val Lys Lys Ile Lys Ile Ser Asn Ile Asn Tyr 
785                 790                 795                 800 


Asn Asp Arg Met Ser Ile Phe Tyr Leu Leu Leu Lys Leu Ile Asp Tyr 
                805                 810                 815     


Arg Glu Leu Thr Asn Leu Arg Gly Asn Leu Glu Lys Tyr Glu Ser Met 
            820                 825                 830         


Asn Lys Asn Lys Ile Tyr Ser Gly Glu Leu Thr Ile Ile Asn Leu Val 
        835                 840                 845             


Asn Leu Asp Asn Asn Lys Val Arg Thr Asn Phe Ser Leu Glu Ala Glu 
    850                 855                 860                 


Asp Ile Gly Lys Phe Leu Lys Ser Ser Ile Thr Ile Lys Asn Ile Ala 
865                 870                 875                 880 


Gln Leu Asn Asn Phe Ser Lys Ile Phe Ala Asp Gly Glu Asn Val Ile 
                885                 890                 895     


Lys His Arg Ser Phe Tyr Asn Ile Lys Lys Tyr Gly Ile Leu Asp Leu 
            900                 905                 910         


Leu Glu Lys Met Ile Ala Arg Ala Asp Leu Lys Ile Ser Lys Glu Glu 
        915                 920                 925             


Ile Lys Lys Tyr Glu Asn Leu Gln Asn Glu Leu Lys Arg Asn Asp Phe 
    930                 935                 940                 


Tyr Lys Ile Gln Glu Gln Ile His Arg Asn Tyr Asn Gln Lys Pro Phe 
945                 950                 955                 960 


Ser Ile Lys Lys Ile Glu Asn Lys Lys Asp Phe Glu Lys Tyr Lys Lys 
                965                 970                 975     


Val Ile Glu Lys Ile Gln Asp Tyr Thr Gln Leu Lys Asn Lys Ile Glu 
            980                 985                 990         


Phe Asn Asp Leu Asn Leu Leu Gln  Ser Leu Ile Phe Arg  Ile Leu His 
        995                 1000                 1005             


Arg Leu  Ala Gly Tyr Thr Ser  Leu Trp Glu Arg Asp  Leu Gln Phe 
    1010                 1015                 1020             


Lys Leu  Lys Gly Glu Phe Pro  Glu Asp Lys Tyr Ile  Asp Glu Ile 
    1025                 1030                 1035             


Phe Asn  Ser Asp Gly Asn Asn  Asn Gln Lys Tyr Lys  His Gly Gly 
    1040                 1045                 1050             


Ile Thr  Asp Lys Tyr Ala Asn  Phe Leu Ile Glu Lys  Glu Glu Glu 
    1055                 1060                 1065             


Lys Ser  Gly Glu Ile Leu Lys  Lys Lys Gln Arg Lys  Lys Lys Ile 
    1070                 1075                 1080             


Lys Glu  Asp Leu Glu Ile Arg  Asn Tyr Ile Ala His  Phe Asn Tyr 
    1085                 1090                 1095             


Leu Pro  Asn Ala Glu Lys Ser  Ile Leu Glu Ile Leu  Glu Glu Leu 
    1100                 1105                 1110             


Arg Glu  Leu Leu Lys His Asp  Arg Lys Leu Lys Asn  Ala Val Met 
    1115                 1120                 1125             


Lys Ser  Ile Lys Asp Ile Phe  Lys Glu Tyr Gly Phe  Ile Val Glu 
    1130                 1135                 1140             


Phe Thr  Ile Ser His Thr Lys  Asn Gly Lys Lys Ile  Lys Val Cys 
    1145                 1150                 1155             


Ser Val  Lys Ser Glu Lys Ile  Lys His Leu Lys Asn  Asn Glu Leu 
    1160                 1165                 1170             


Ile Thr  Thr Arg Asn Ser Glu  Asp Leu Cys Asp Leu  Val Lys Ile 
    1175                 1180                 1185             


Met Leu  Glu Tyr Lys Lys Leu  Gln Lys 
    1190                 1195         


<210>  586
<211>  1163
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  586

Met Gly Ser Gly Lys Tyr Arg Ile Thr Lys Ile Ala Arg Lys Trp Asp 
1               5                   10                  15      


Lys Asn Glu Asn Trp Glu Lys Ile Ile Leu Lys Arg Ile Val Gly Asn 
            20                  25                  30          


Lys Lys Ile Lys Tyr Val Asn Glu Asn Asn Asn Lys Asp Val Asp Ile 
        35                  40                  45              


Thr Asp Thr Tyr Tyr Asn Ile Leu Ser Lys Asn Asn Ser Lys Phe Leu 
    50                  55                  60                  


Gly Ser Glu Glu Gln Phe Leu Phe Lys Val Asn Lys Met Asp Arg Asn 
65                  70                  75                  80  


Ile Lys Asn Asp Tyr Val Ile Ile Lys Asp Tyr Asn Asp Glu Glu Phe 
                85                  90                  95      


Glu Lys Phe Asp Lys Lys Ile Phe Phe Ser Arg Lys Ile Lys Val Asn 
            100                 105                 110         


Asn Glu Asp Arg Glu Lys Ile Cys Arg Asn Phe Tyr Glu Asp Glu Arg 
        115                 120                 125             


Glu Ile Met Lys Lys Arg Leu Glu Glu Ala Lys Asn Phe Asn Asn Ile 
    130                 135                 140                 


Ile Phe Asn Ile Cys Asn Lys Ile Phe Lys Leu Glu Tyr Leu Asp Tyr 
145                 150                 155                 160 


Thr Asp Glu Lys Val Tyr Lys Ile Phe Gln Asn Glu Ile Lys Val Lys 
                165                 170                 175     


Asp Val Lys Asn Leu Lys Glu Ala Phe Lys Gln Gln Glu Lys Gly Leu 
            180                 185                 190         


Glu Thr Asp Lys Leu Leu Ala Ile Ser Phe Asn Lys Asn Arg Asn Asn 
        195                 200                 205             


Ile Leu Leu Glu Phe Val Gln Gln Ile Thr Lys Gln Glu Phe Lys Asn 
    210                 215                 220                 


Gln Lys Glu Leu Glu Asn Trp Phe Ser His Ser Gly Glu Lys Tyr Cys 
225                 230                 235                 240 


Lys Lys Ile Phe Lys Ile Tyr Ser Asn Met Ser Gln Lys Glu Lys Tyr 
                245                 250                 255     


Ser Lys Leu Leu Gly His Lys Asn Lys Ser Ile Ala Ser Ile Ser Glu 
            260                 265                 270         


Lys Lys Glu Thr Leu Gln Arg Arg Leu Lys Leu Gly Asn Tyr Ser Asn 
        275                 280                 285             


Tyr Asp Leu Arg Lys Tyr Tyr Gln Lys Asp Tyr Lys Glu Glu Ala Ile 
    290                 295                 300                 


Arg Glu Leu Lys Asp Lys Asn Lys Glu Glu Leu Glu Arg Glu Ile Glu 
305                 310                 315                 320 


Lys Leu Ile Lys Glu Asn Tyr Lys Ile Asp Glu Leu Cys Asp Glu Ile 
                325                 330                 335     


Ser Asn Leu Glu Phe Ser Phe Val Asp Ser Lys Lys Glu Asn Lys Asp 
            340                 345                 350         


Lys Met Ser Glu Ile Ile Val Lys Ile Lys Glu His Tyr Lys Asn Asn 
        355                 360                 365             


Val Asn Ile Glu Glu Arg Leu Glu Asn Lys Glu Lys Tyr Ile Leu Ser 
    370                 375                 380                 


Met Ile His Asn Tyr Val Lys Gly Arg Tyr Arg Lys Cys Leu Glu Leu 
385                 390                 395                 400 


Gln Gln Lys Glu Asn Val Asp Phe Glu Asn Leu Glu Lys Arg Ile Lys 
                405                 410                 415     


Glu Ile Phe Asp Ser Asn Glu Val Thr Lys Lys Leu Lys Lys Ser Ile 
            420                 425                 430         


Ile Asn Lys Val Asn Ser Tyr Lys Ile Phe Glu Met Lys Phe Gln Asn 
        435                 440                 445             


Pro Asn Ile Glu Ser Ser Asp Asp Leu Glu Ile Leu Lys Ala Glu Glu 
    450                 455                 460                 


Thr Phe Leu Asn Lys Leu Ser Thr Ala Val Ser Lys Val Gly Tyr Thr 
465                 470                 475                 480 


Leu Asn Thr Leu Leu Glu Val Asn Pro Glu Lys Asp Ile Leu Glu Lys 
                485                 490                 495     


Tyr Glu Glu Val Glu Lys Leu Cys Thr Asn Asn Ser Ile Lys Asn Leu 
            500                 505                 510         


Cys Thr Val Tyr Ser Glu Ile Asn Asn Asn Glu Lys Leu Leu Lys Gly 
        515                 520                 525             


Met Ile Tyr Phe Ile Gln Gly Leu Arg Gln Gln Val Leu His Pro Lys 
    530                 535                 540                 


Ile Leu Trp Glu Lys Asn Val His Lys Ala Glu Lys Val Lys Glu Lys 
545                 550                 555                 560 


Glu Lys Ile Val Ile Arg Phe Gln Asn Glu Gly Lys Ala Tyr Asn Lys 
                565                 570                 575     


Lys Arg Ile Glu Glu Tyr Phe Glu Asn Ile Leu Glu Lys Ile Pro Asn 
            580                 585                 590         


Tyr Phe Ile Glu Lys Tyr Glu Ser Asn Asn Val Phe Asn Ile Tyr Arg 
        595                 600                 605             


Asn Phe Ile Asp Glu Ile Phe Glu Ile Ile Asp Lys Phe Asp Phe Lys 
    610                 615                 620                 


Glu Ser Asn Ser Ile Ser Tyr Leu Phe Pro Lys Phe His Lys Ile Tyr 
625                 630                 635                 640 


Lys Arg Ile Cys Lys Ser Glu Asn Ile Asn Asp Arg Gln Asn Gly Ala 
                645                 650                 655     


Arg Lys Tyr Leu Leu Gln Thr Ile Tyr Tyr Tyr Tyr Phe Gln Tyr Glu 
            660                 665                 670         


Ile Glu Asn Asn Lys Asn Asp Ile Phe Lys Tyr Leu Asn Leu Tyr Lys 
        675                 680                 685             


Ser Lys Ile Lys Ala Lys Lys Ile Ser Tyr Ser His Ile Ile Asp Asn 
    690                 695                 700                 


Lys Asp Val Asn Asn Lys Asn Ile Glu Ile Leu Tyr Arg Asn Ile Gln 
705                 710                 715                 720 


Arg Glu Gly Met Leu Asn Asn Arg Leu Leu Gln Met Asn Asn Glu Trp 
                725                 730                 735     


Ile Glu Phe Met Val Val Gln Phe Ser Glu Phe Leu Thr Asn Lys Lys 
            740                 745                 750         


Leu Asn Trp Ile Leu Asp Asp Leu Ser Glu Tyr Lys Lys Lys Glu Lys 
        755                 760                 765             


Leu Asp Glu Asn Asp Lys Asn Lys Leu Leu Lys Thr Leu Lys Gln Lys 
    770                 775                 780                 


Met Asn Lys Lys Ile Thr Tyr Ser Asn Asp Ser Tyr Val Phe Ile Ser 
785                 790                 795                 800 


Leu Ala Gln Phe Leu Asp Leu Lys Glu Ile Ser Asn Leu Ile His Asp 
                805                 810                 815     


Ile Lys Lys Phe Ile Gln Phe Arg Glu Lys Asn Val Ser Lys Tyr Lys 
            820                 825                 830         


Pro Glu Lys Asn Lys Leu Tyr Ile Lys Glu Leu Arg Lys Val Leu Tyr 
        835                 840                 845             


Ile Leu Lys Val Met Leu Glu His Lys Glu Arg Val Ile Gln Lys His 
    850                 855                 860                 


Tyr Leu Glu Ser Tyr Asp Glu Asn Ile Ser Ile Ile Tyr Gly Lys Asp 
865                 870                 875                 880 


Ile Glu Arg Lys Asp Ile Lys Asp Ile Lys Ile Lys Ile Lys Asn Glu 
                885                 890                 895     


Asn Gln Glu Val Ile Asn Gln Pro Leu Tyr Lys Ser Gly Asn Asp Glu 
            900                 905                 910         


Asn Ser Ser Trp Ile Val Leu Tyr Gly Ile Glu Gln Ala Lys Arg Asn 
        915                 920                 925             


Gly Thr Phe Lys Phe Phe Glu Gly Phe Phe Asn Leu Asn Asp Asp Ile 
    930                 935                 940                 


Lys Leu Cys Lys Glu Asn Ile Glu Lys Tyr Glu Glu Leu Tyr Asn Glu 
945                 950                 955                 960 


Lys Glu Glu Asn Gln Arg Lys Val Asp Glu Tyr Ile Ser Ser Glu Glu 
                965                 970                 975     


Asn Asn Asn Ile Asp Glu Ile Glu Glu Ile Asn Asn Asn Lys Gln Leu 
            980                 985                 990         


Phe Tyr Tyr Tyr Lys Asn Met Ile  Tyr Gly Asp Gly Leu  Lys Lys Gly 
        995                 1000                 1005             


Tyr Asp  Phe Ile Asn Asp Ile  Tyr Ser His Tyr Leu  Ser Trp Ala 
    1010                 1015                 1020             


Tyr Arg  Val Glu Arg Asp Cys  Lys Ile Tyr Lys Ile  Lys Glu Tyr 
    1025                 1030                 1035             


Glu Asn  Lys Lys Asn Phe Asn  Glu Tyr Lys Phe Lys  Glu Tyr Lys 
    1040                 1045                 1050             


Ser Ile  Lys Asn Phe Arg Asn  Glu Ile Ala His Phe  Asn Tyr Phe 
    1055                 1060                 1065             


Gln Lys  Thr Asn Lys Ser Leu  Leu Glu Leu Leu Asn  Asp Phe Tyr 
    1070                 1075                 1080             


Asp Ile  Phe Asp Tyr Asn Leu  Lys Tyr Gln Arg Asp  Val Gln Lys 
    1085                 1090                 1095             


Val Ile  Asn Asn Ile Phe Glu  Lys Tyr Gln Ile Val  Arg Lys Asp 
    1100                 1105                 1110             


Arg Gly  Pro Val Val Phe Tyr  Cys Lys Thr Asp Lys  Lys Leu Lys 
    1115                 1120                 1125             


Leu Ser  Glu Asn Ile Ile Pro  Lys Lys His Leu Lys  Tyr Pro Glu 
    1130                 1135                 1140             


Ile Lys  Leu Ile His Glu Lys  Tyr Val Glu Phe Phe  Lys Lys Leu 
    1145                 1150                 1155             


Phe Glu  Tyr Lys Lys 
    1160             


<210>  587
<211>  1247
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  587

Met Lys Ile Thr Lys Arg Lys Trp Gly Glu His His Pro Pro Leu Tyr 
1               5                   10                  15      


Phe Tyr Arg Asp Glu Asp Ser Gly Arg Leu Leu Ala Gln Asn Asp Arg 
            20                  25                  30          


Lys Gln Asp Tyr Thr Asp Thr Leu Phe Asn Asp Ile Ala Gln Asp Thr 
        35                  40                  45              


Phe Glu Arg Ser Leu Arg Asn Arg Leu Leu Lys Thr Pro Glu Lys Gly 
    50                  55                  60                  


Asp Lys Arg Phe Tyr Ser Asn Glu Ile Val Lys Leu Val Glu Lys Leu 
65                  70                  75                  80  


Cys Gln Gly Ala Asp Val Ala Glu Ile Met Lys Ser Met Glu Arg Ser 
                85                  90                  95      


Glu Lys Leu Arg Pro Lys Asn Glu Lys Glu Ile Lys Asn Leu Lys Lys 
            100                 105                 110         


Gln Leu Asp Gly Thr Leu Ser Glu Tyr Gly Lys Arg Tyr Thr Ala Pro 
        115                 120                 125             


Glu Gly Ala Met Thr Leu Asn Asp Ala Leu Phe Tyr Leu Val Glu Gly 
    130                 135                 140                 


Asn Pro Leu Lys Gln Ala Met Ala Lys Ala Glu Leu Gly Lys Ile Arg 
145                 150                 155                 160 


Glu Ala Leu Ile Lys Glu Lys Glu Asn Arg Ile Asn Arg Val Arg Tyr 
                165                 170                 175     


Ser Ile Lys Asn Asn Lys Ile Pro Leu Arg Ile Gln Gly Asp Gly Gly 
            180                 185                 190         


Ile Thr Pro Asn Asn Asp Arg Ala Ala Trp Leu Leu Gly Leu Met Lys 
        195                 200                 205             


Pro Ala Asp Pro Ala Lys Gly Ile Thr Asp Cys Tyr Pro Leu Leu Gly 
    210                 215                 220                 


Glu Leu Glu Glu Val Phe Asp Phe Asp Lys Leu Ser Lys Thr Leu His 
225                 230                 235                 240 


Glu Lys Ile Ser Arg Cys Gln Gly Arg Pro Arg Ser Ile Ala Met Ala 
                245                 250                 255     


Val Asp Glu Ala Leu Lys Gln Tyr Leu Arg Glu Leu Trp Glu Lys Ser 
            260                 265                 270         


Pro Ser Arg Gln Gln Asp Leu Lys Tyr Tyr Phe Gln Ala Val Gln Glu 
        275                 280                 285             


Tyr Phe Lys Asp Asn Phe Pro Ile Arg Thr Lys Arg Met Gly Ala Arg 
    290                 295                 300                 


Leu Arg Gln Glu Leu Leu Lys Asp Lys Thr Ser Leu Ser Arg Leu Leu 
305                 310                 315                 320 


Glu Pro Lys His Met Ala Asn Ala Val Arg Arg Arg Leu Ile Asn Gln 
                325                 330                 335     


Ser Thr Gln Met His Ile Leu Tyr Gly Lys Leu Tyr Ala Tyr Cys Cys 
            340                 345                 350         


Gly Glu Asp Gly Arg Leu Leu Val Asn Ser Glu Thr Leu Gln Arg Ile 
        355                 360                 365             


Gln Val His Glu Ala Val Lys Lys Gln Ala Met Thr Ala Val Leu Trp 
    370                 375                 380                 


Ser Ile Ser Arg Leu Arg Tyr Phe Tyr Gln Phe Glu Asp Gly Asp Ile 
385                 390                 395                 400 


Leu Ser Asn Lys Asn Pro Ile Lys Asp Phe Arg Asp Lys Phe Leu Arg 
                405                 410                 415     


Asp Thr Asn Lys Tyr Thr His Glu Asp Val Glu Ala Cys Lys Glu Lys 
            420                 425                 430         


Leu Gln Asp Phe Phe Pro Leu Lys Glu Leu Gln Glu Lys Ile Lys Glu 
        435                 440                 445             


Asp Ala Lys Gly Leu Gln Glu Thr Asp Asn Lys Gln Ala Asp Thr Thr 
    450                 455                 460                 


Asp Phe Lys Ala Ile Gly His Ile Val Arg Asp Asp Arg Lys Leu Cys 
465                 470                 475                 480 


Asn Gln Leu Leu Ala Glu Cys Val Ser Cys Ile Gly Glu Leu Arg His 
                485                 490                 495     


His Ile Phe His Tyr Lys Asn Val Thr Leu Ile Gln Ala Leu Lys Arg 
            500                 505                 510         


Ile Ala Asp Lys Val Lys Pro Glu Asp Leu Ser Val Leu Arg Ala Ile 
        515                 520                 525             


Tyr Leu Leu Asp Arg Arg Asn Leu Lys Lys Ala Phe Ala Lys Arg Ile 
    530                 535                 540                 


Ser Ser Met Asn Leu Pro Leu Tyr Tyr Arg Glu Asp Leu Leu Ser Arg 
545                 550                 555                 560 


Ile Phe Lys Lys Glu Gly Thr Ala Phe Phe Leu Tyr Ser Ala Lys Ile 
                565                 570                 575     


Gln Met Thr Pro Ser Phe Gln Arg Val Tyr Glu Arg Gly Lys Asn Leu 
            580                 585                 590         


Arg Arg Glu Phe Glu Cys Glu Arg Met Lys Ala Glu Ala Ser Asn Gly 
        595                 600                 605             


Gln Asn Gly Gln Asp Gly Asp Arg Leu Lys Trp Phe Arg Gln Leu Ala 
    610                 615                 620                 


Ala Gly Asp Ser Ala Asp Thr His Phe Asn Trp Ala Val Glu Ala Tyr 
625                 630                 635                 640 


Ala Glu Ser Ala Ala Asp Val Glu Asn Asn Val Glu Phe Asp Thr Asp 
                645                 650                 655     


Val Asp Ala Gln Arg Ala Leu Arg Asn Leu Leu Leu Leu Ile Tyr Arg 
            660                 665                 670         


His His Phe Leu Pro Glu Val Gln Lys Asp Glu Thr Leu Val Thr Gly 
        675                 680                 685             


Lys Ile His Lys Val Leu Glu Arg Asn Arg Gln Leu Ser Glu Gly Gln 
    690                 695                 700                 


Gly Pro Asn Gln Gly Lys Ala His Gly Tyr Ser Val Ile Glu Glu Leu 
705                 710                 715                 720 


Tyr His Glu Gly Met Pro Leu Ser Asp Leu Met Lys Gln Leu Gln Arg 
                725                 730                 735     


Arg Ile Ser Glu Thr Glu Arg Glu Ser Arg Glu Leu Ala Gln Glu Lys 
            740                 745                 750         


Thr Asp Tyr Ala Gln Arg Phe Ile Leu Asp Ile Phe Ala Glu Ala Phe 
        755                 760                 765             


Asn Asp Phe Leu Glu Ala His Tyr Gly Glu Glu Tyr Leu Glu Ile Met 
    770                 775                 780                 


Ser Pro Arg Lys Asp Ala Glu Ala Ala Lys Lys Trp Val Lys Glu Ser 
785                 790                 795                 800 


Lys Thr Val Asp Leu Lys Thr Ser Ile Asp Glu Lys Glu Pro Glu Gly 
                805                 810                 815     


His Leu Leu Val Leu Tyr Pro Val Leu Arg Leu Leu Asp Glu Arg Glu 
            820                 825                 830         


Leu Gly Glu Leu Gln Gln Gln Met Ile Arg Tyr Arg Thr Ser Leu Ala 
        835                 840                 845             


Ser Trp Gln Gly Glu Ser Asn Phe Ser Glu Glu Ile Arg Ile Ala Gly 
    850                 855                 860                 


Gln Ile Glu Glu Leu Thr Glu Leu Val Lys Leu Thr Glu Pro Glu Pro 
865                 870                 875                 880 


Gln Phe Ala Glu Glu Val Trp Gly Lys Arg Ala Lys Glu Ala Phe Glu 
                885                 890                 895     


Asp Phe Ile Glu Gly Asn Met Lys Asn Tyr Glu Ala Phe Tyr Leu Gln 
            900                 905                 910         


Ser Asp Asn Asn Lys Pro Val Tyr Arg Arg Asn Met Ser Arg Leu Leu 
        915                 920                 925             


Arg Ser Gly Leu Met Gly Val Tyr Gln Lys Val Leu Ala Ser His Lys 
    930                 935                 940                 


Gln Ala Leu Lys Arg Asp Tyr Leu Leu Trp Ser Glu Lys His Trp Asn 
945                 950                 955                 960 


Val Lys Asp Glu Asn Gly Ala Asp Ile Ser Ser Ala Glu Gln Ala Gln 
                965                 970                 975     


Cys Leu Leu Gln Arg Leu His Arg Lys Tyr Ala Glu Ser Pro Ser Arg 
            980                 985                 990         


Phe Thr Glu Glu Asp Cys Lys Leu  Tyr Glu Lys Val Leu  Arg Arg Leu 
        995                 1000                 1005             


Glu Asp  Tyr Asn Gln Ala Val  Lys Asn Leu Ser Phe  Ser Ser Leu 
    1010                 1015                 1020             


Tyr Glu  Ile Cys Val Leu Asn  Leu Glu Ile Leu Ser  Arg Trp Val 
    1025                 1030                 1035             


Gly Phe  Val Gln Asp Trp Glu  Arg Asp Met Tyr Phe  Leu Leu Leu 
    1040                 1045                 1050             


Ala Trp  Val Arg Gln Gly Lys  Leu Asp Gly Ile Lys  Glu Lys Asp 
    1055                 1060                 1065             


Val Ser  Gly Ile Phe Tyr Lys  Gly Ser Ile Ile Cys  Lys Leu Phe 
    1070                 1075                 1080             


Asn Thr  Leu Glu Gly Gly Asn  Trp Ala Ala Phe Ala  Ser Ile Tyr 
    1085                 1090                 1095             


Cys Pro  Gly Ser Lys Arg Thr  Lys Phe Leu Lys Val  Asn Asn Asp 
    1100                 1105                 1110             


Val His  Ala Thr Ala Pro Leu  Ser His Glu Lys Cys  Gln Tyr Glu 
    1115                 1120                 1125             


Phe Leu  Val Ala Arg Asn Met  Ile Ala His Leu Asp  Leu Met Arg 
    1130                 1135                 1140             


Lys Asn  Gly Trp Arg Leu Glu  Ala Gly Lys Thr Cys  Ser Val Met 
    1145                 1150                 1155             


Glu Asp  Tyr Ile Asn Arg Leu  Arg Phe Leu Leu Ser  Tyr Asp Gln 
    1160                 1165                 1170             


Lys Arg  Met Asn Ala Val Thr  Lys Thr Leu Gln Gln  Ile Phe Asp 
    1175                 1180                 1185             


Arg His  Lys Val Lys Ile Arg  Phe Thr Val Glu Lys  Gly Gly Met 
    1190                 1195                 1200             


Leu Lys  Ile Glu Asp Val Thr  Ala Asp Lys Ile Val  His Leu Lys 
    1205                 1210                 1215             


Gly Ser  Arg Leu Ser Gly Ile  Glu Ile Pro Ser His  Gly Glu Arg 
    1220                 1225                 1230             


Phe Ile  Asp Thr Leu Lys Ala  Leu Met Val Tyr Pro  Arg Gly 
    1235                 1240                 1245         


<210>  588
<211>  1218
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  588

Met Arg Ile Val Arg Pro Tyr Gly Glu Ser Val Ala Pro Gly Ala Gly 
1               5                   10                  15      


Ser Glu Arg Leu Leu Arg Pro Lys Lys Gln Leu Arg Asp Gln Ile Gly 
            20                  25                  30          


Asp Ala Asp Arg Arg Ile Pro Thr Phe Ala Ala Gly His Asp Glu Leu 
        35                  40                  45              


Val Ile Ala Gln Trp Ile Ser Thr Ile Asp Lys Ile Ala Thr Lys Pro 
    50                  55                  60                  


Lys Gly Asn Lys Glu Pro Thr Pro Arg Gln Arg Ala Leu Arg Glu Lys 
65                  70                  75                  80  


Leu Gly Lys Ala Gly Trp Asp Arg Leu Val Asp Gln Lys Leu Leu Pro 
                85                  90                  95      


Gly Leu Pro Lys Asp Gln Asp Asp Tyr Leu Gly Lys Leu Trp Trp Phe 
            100                 105                 110         


Lys Ile His Pro Tyr Pro Lys Gly Thr Lys Ala Pro Lys Val Val Asn 
        115                 120                 125             


Gly Arg Glu Ile Pro Asp Pro Arg Gly Arg Trp Tyr Ser Arg Phe Val 
    130                 135                 140                 


Cys Asp Val Ala Pro Asp Asp Ile Asp Ala Ala Thr Val Ala Ala Arg 
145                 150                 155                 160 


Val His Glu His Leu His Val Ala Glu Tyr Arg His Gly Thr Glu Gln 
                165                 170                 175     


Lys His Asp Lys Gly Arg Ile Glu Arg Arg Ala Arg Ser Ile Ala Lys 
            180                 185                 190         


Asn Thr Ala Ser Leu Ala Gln Val Thr Lys Glu Arg Pro Thr Trp Thr 
        195                 200                 205             


Glu Asp Asp Val Ala Thr Tyr Ala Gln Thr Ala Gly Asp Val Ala Thr 
    210                 215                 220                 


Ala Ile Lys Gln Ala Ala Glu Ala Arg Glu Ala Asp Asn Arg Arg Val 
225                 230                 235                 240 


Gly Ala Asp Val Ala Ala Glu Val Leu Tyr Pro Ala Phe Gly Lys Leu 
                245                 250                 255     


Phe Pro Asn Lys Gly Ile Lys Glu Leu Glu Asn Gln Ser Gly Leu Pro 
            260                 265                 270         


Ala Leu His Leu Ala Ile Arg Asp Phe Tyr Gln Arg Arg Leu Lys Arg 
        275                 280                 285             


His Lys Lys Asp Gln Pro Glu His Lys Met Ala Arg Arg Lys Val Ser 
    290                 295                 300                 


Thr Leu Leu Pro Ala Asp Met Ala Gly Leu Ala Ala Met Leu Arg His 
305                 310                 315                 320 


Thr Ala Ala Asn Arg Asp Val Ala Ala Leu Val Arg Leu Gly Lys Val 
                325                 330                 335     


Ile His Tyr Glu Ala Ala Phe Ala Ala Gly Gln Lys Ala Ala Asp Gly 
            340                 345                 350         


Asp Ala Pro Ala His Val Leu Glu Lys Trp Pro Ala Glu Val Lys Ala 
        355                 360                 365             


Ser His Tyr Trp Ser Ser Glu Gly Gln Ala Glu Ile Lys Arg Asn Glu 
    370                 375                 380                 


Ala Phe Val Arg Ile Trp Arg His Ser Leu Ala Leu Ala Ala Gln Thr 
385                 390                 395                 400 


Leu Arg Asp Trp Ala Ser Pro Asp Gly Ser Phe His Thr Asp Ile Leu 
                405                 410                 415     


Ser Glu Lys Gln Phe Glu Thr Leu Thr Lys Asn Leu Asp Leu Asp His 
            420                 425                 430         


His Ala Arg Lys Leu Ala Val Leu Leu Gly Asn Arg Ala Glu Phe Phe 
        435                 440                 445             


Leu Lys Gly Arg Gly Asp Ala Phe Gln Lys Gln Thr Leu Lys Leu Ala 
    450                 455                 460                 


Leu Gln Gly Leu Thr Gln Leu Arg His Asn Ser Phe His Phe Asn Gly 
465                 470                 475                 480 


Arg Gly Gly Phe Ala Asp Ala Leu Lys Phe Thr Arg Lys Pro Glu Ile 
                485                 490                 495     


Thr Ala Asp Gln His Met Trp Asp Ala Leu Gly Ala Leu Trp Ala Thr 
            500                 505                 510         


Asp Leu Glu Glu Arg Gly Lys Arg Leu Ile Asp Thr Leu Glu Ala Ala 
        515                 520                 525             


His Leu His His Phe Phe Asp Trp Glu His Asn Lys Arg Leu Ile Gly 
    530                 535                 540                 


Ala Val Ala Arg Ala Lys Leu Ala Glu Gly Ala Glu Asp Leu Pro Leu 
545                 550                 555                 560 


Pro Arg Phe Arg Arg Leu Leu Asp Arg Ala Ala Asn Ile Arg Gly Lys 
                565                 570                 575     


Asp Gly Ile Asn Leu Arg Leu Pro Lys Pro Val Asn Arg Gln Asp Met 
            580                 585                 590         


Glu Asp Phe Pro Ala Leu His Ala Lys Tyr Val Ala Leu Lys Leu Leu 
        595                 600                 605             


Tyr Glu Asn Pro Phe Arg Gln Trp Val Gly His Arg Asp Arg Arg Asp 
    610                 615                 620                 


Leu Val Asn Lys Leu Ile Asp Arg Ala Val Arg Arg Ala Asp Lys Ala 
625                 630                 635                 640 


Ala Lys Asp Leu His Gly Lys Ala Asp Ala Asp Arg Arg Leu Ile Ile 
                645                 650                 655     


Thr Ala Lys Ala Lys Gly Leu Gly Arg Leu Gly Glu Gly Glu Lys Leu 
            660                 665                 670         


His Asp Phe Ala Phe Arg Leu Ser Arg Glu Thr Ala Ser Glu Met Arg 
        675                 680                 685             


Val Gln Arg Gly Tyr Asp Ser Asp Gly Glu Arg Ala Arg Glu Gln Ala 
    690                 695                 700                 


Ala Phe Ile Glu Glu Leu Leu Ile Asp Val Leu Ala Gln Ala Phe Asp 
705                 710                 715                 720 


His Tyr Leu Arg Lys Lys Lys Phe Asp Phe Leu Val Asp Leu Arg Ala 
                725                 730                 735     


Asp Glu Pro Arg Pro Lys Glu Pro Lys Cys Ala Leu Arg Arg Pro Val 
            740                 745                 750         


Leu Asp Ala Glu Gly Ala Ala Ala Pro Gln Trp Gln Val Leu Leu Tyr 
        755                 760                 765             


Phe Leu Leu His Leu Ile Pro Val Asp Asp Ile Gly Arg Leu Val His 
    770                 775                 780                 


Gln Ile Arg Lys Trp Asp Ile Thr Ala Gly Lys Ala Ala Gly Thr Thr 
785                 790                 795                 800 


Arg Ala Ala Asp Asp Asp Val Asp Arg Val Ala Arg Thr Leu Thr Leu 
                805                 810                 815     


Tyr Leu Asp Met His Asp Ala Lys Phe Thr Gly Asp Gln Ala Leu Gln 
            820                 825                 830         


Ala Leu Ala Pro Leu His Glu Leu Tyr Ala Ser Lys Glu Thr Phe Glu 
        835                 840                 845             


Arg Phe Phe Leu Arg Lys Ala Thr Asp Asp Asn Glu Tyr Leu Pro Arg 
    850                 855                 860                 


Arg Gly Leu Arg Glu Ile Leu Arg Phe Gly His Leu Pro Pro Leu Arg 
865                 870                 875                 880 


Ala Ile Phe Ala Ala His Lys Val Asp Asp Asp Thr Val Gln Lys Val 
                885                 890                 895     


Glu Ala Ala Glu Lys Gly Pro Leu Val Ala Ala Gln Arg Glu Arg Glu 
            900                 905                 910         


Arg Leu His Lys Leu Trp Val Asp Gln Arg Arg Lys Leu Gly Ala Glu 
        915                 920                 925             


Asp Leu Arg Cys Tyr Val Asp Thr Leu Ala Glu Val Thr Arg His Arg 
    930                 935                 940                 


His Ala Ala Ala His Val Arg Leu Val Asp His Val Glu Leu His Arg 
945                 950                 955                 960 


Leu Met Leu Ala Val Leu Gly Arg Leu Leu Asp Phe Ala Gly Leu Phe 
                965                 970                 975     


Glu Arg Asp Leu Tyr Phe Ala Met Leu Ala Leu Ile Tyr Arg Ala Pro 
            980                 985                 990         


Ser Ser Pro Gln Ala Val Leu Asp  Glu Ala Asp Arg Glu  Leu Leu Arg 
        995                 1000                 1005             


Arg Gly  Gln Ile Val Glu Thr  Trp Arg Lys Leu Gln  Asp Ser Thr 
    1010                 1015                 1020             


Leu Lys  Asp Glu Leu Ala Gln  Leu Phe Asp Pro Thr  Ser Gly Arg 
    1025                 1030                 1035             


Val Ile  Arg Val Arg Asn Asp  Phe Ala His Phe Asn  Met Leu Asn 
    1040                 1045                 1050             


Pro Arg  Arg Ser Arg Gly Ala  Thr Ile Asp Leu Thr  Ala Gln Val 
    1055                 1060                 1065             


Asn Ala  Ala Arg Arg Leu Met  Gly Tyr Asp Arg Lys  Leu Lys Asn 
    1070                 1075                 1080             


Ala Val  Ala Gln Ser Val Ile  Glu Leu Val Ala Arg  Glu Gly Leu 
    1085                 1090                 1095             


His Leu  Asp Trp Gly Met Gln  Val Leu Asp Gly Ala  His Val Leu 
    1100                 1105                 1110             


Val Asp  Ala Arg Val Arg Gly  Lys Gln Ala Ala His  Leu Gly Asn 
    1115                 1120                 1125             


Leu Gly  Leu Phe Glu Lys Gly  Gln Gly Glu Arg Glu  Lys Lys Pro 
    1130                 1135                 1140             


Ala His  Arg Leu Thr Glu Thr  Leu Ser Gly Pro His  Leu Ala Glu 
    1145                 1150                 1155             


Met Ala  Ala Thr Leu Phe Ala  Gly Arg Val Ala His  Ala Thr Asp 
    1160                 1165                 1170             


Ala Ala  Ala Leu Pro Arg Ala  Ala Ile Asp Trp Gln  Arg Ser Ala 
    1175                 1180                 1185             


Ala Pro  Glu Thr Asn Thr Lys  Gln Ala His Asn His  Pro Gln Arg 
    1190                 1195                 1200             


Pro Pro  Lys Pro Arg Ile Gln  Arg Pro Pro Leu Gln  Ala Ala Lys 
    1205                 1210                 1215             


<210>  589
<211>  1342
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  589

Met Lys Val Lys Glu Gly His Val His Thr Ala Val Gly Lys Asn Glu 
1               5                   10                  15      


Cys Lys Lys Ser Val Ala Arg Met Ile Tyr Lys Ser Pro Val Pro Glu 
            20                  25                  30          


Glu Asn Leu Glu Val Arg Ser His Leu Ala Lys Gln Asn Gly Asn Asn 
        35                  40                  45              


Gln Arg Met Tyr Ser Leu Phe Gly Gly Ser Phe Phe Tyr Leu Glu Arg 
    50                  55                  60                  


Glu Phe Glu Gly Asp Leu Lys Ser Lys Glu Leu Glu Phe Gln Lys Asp 
65                  70                  75                  80  


Leu Ala Lys Lys Ile His Asp Lys Val Thr Tyr Leu Glu Arg Leu Leu 
                85                  90                  95      


Leu Lys Glu Glu Trp Asn Met Pro Glu Asp Ile Ala Gln Leu Asn Gly 
            100                 105                 110         


Cys Ser Asp Lys Glu Lys Trp Glu Glu Thr Val Glu Lys Ile Val Glu 
        115                 120                 125             


Ala Lys Ile Glu Gln Gln Leu Gln Met Leu Arg Asn Tyr Asn Ala His 
    130                 135                 140                 


Gly Arg Ile Tyr Phe Gln Asn Lys Glu Arg Thr Gln Gly Val Asp Glu 
145                 150                 155                 160 


Val Asp Phe Ile His Lys Phe Val Thr Phe Gln Leu Arg Lys Lys Leu 
                165                 170                 175     


Arg Lys Thr Val Lys Glu Gln Glu Ala Gly Lys Glu Tyr Thr Ile Tyr 
            180                 185                 190         


Leu Pro Asp Val Ile Glu Lys Leu Val Ile Ala Leu Cys Ala Gly Gly 
        195                 200                 205             


Asn Tyr Asn Lys Lys Leu Glu Lys Ile Lys Ser Tyr Glu Cys Arg Val 
    210                 215                 220                 


Phe Leu Lys Ala Leu Asn Asn Asp Tyr Leu Cys Leu Lys Gln Ile Arg 
225                 230                 235                 240 


Lys Ile Ala Asn Ser Ile Glu Lys Lys Asn Val Lys Val Gln Ile Gly 
                245                 250                 255     


Glu Gly Arg Leu Leu Gln Leu Ser Asn Ala Lys His Pro Lys Lys Lys 
            260                 265                 270         


Val Ile Phe Gly Phe Met Lys Lys Tyr Ala Asn Ser Glu Arg Ala Glu 
        275                 280                 285             


Gln Lys Lys Met Leu Cys His Met Gln Met Leu Ile Val Leu Phe Leu 
    290                 295                 300                 


Glu Gly Gln His Ala Glu Glu Arg Leu Asn Gln Ala Gln Asp Lys Gly 
305                 310                 315                 320 


Ile Trp Gln Lys Asn Arg Tyr Gln Trp Ser Glu Asn Asp Val Phe Gly 
                325                 330                 335     


Phe Leu Glu Gln Glu Gly Gly Arg Arg Asn Glu Glu Lys Ile Glu Asn 
            340                 345                 350         


Leu Leu Gln Arg Lys Phe Arg Lys Gly Ile Ser Ala Val Glu Lys Lys 
        355                 360                 365             


Arg Leu Arg Lys Gln Ile Gln Glu Thr Val Trp Glu Ile Ile Ser Glu 
    370                 375                 380                 


His Phe Trp Lys Ala Ile Asp Glu Leu Lys Lys Ile Glu Tyr Glu Gly 
385                 390                 395                 400 


Glu Asp Lys Glu Ile Glu Asp Lys Lys Ala Glu Asp Ile Phe Trp Leu 
                405                 410                 415     


Glu Phe Ile Glu Arg Thr Val Glu Arg Ala Leu Gly Glu Lys Arg Leu 
            420                 425                 430         


Gly Tyr Phe Lys Leu Arg Leu Ser Trp Leu Tyr Gln Phe Val Trp Arg 
        435                 440                 445             


Asp Trp Val Ser Tyr Leu Ala Leu Lys Tyr Ile Asp Met Gly Lys Ala 
    450                 455                 460                 


Val Tyr His Phe Ala Met Pro Asp Leu Ser Asp Arg Lys Gly Lys Met 
465                 470                 475                 480 


Cys Ile Lys Glu Ala Ile Leu Pro Gln Asn Val Asp Glu Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Leu Ile Lys Ala Asp Glu Thr Leu Glu Arg Asp Leu 
            500                 505                 510         


Ser Leu Tyr Ile Ser Phe Ala Val Asn Arg Met Gly Arg Ala Val Ala 
        515                 520                 525             


Pro Glu Ser Ser Tyr Glu Lys Ile Glu Tyr Lys Lys Asp Lys His Gly 
    530                 535                 540                 


Arg Val Arg Glu Ile Asp Tyr Thr Asp Leu Leu Phe Leu Asn Cys Gly 
545                 550                 555                 560 


Phe Ser Thr Arg Ala Glu Glu Val Pro Glu Gly Glu Ser Arg Phe Ile 
                565                 570                 575     


Val Tyr Thr Asp Tyr Gln Arg Arg Leu Leu Gln Tyr Phe Gly Gly Gln 
            580                 585                 590         


Ser Trp Tyr Lys Asp Ile Glu Glu Gly Lys Lys Tyr Glu Leu Ile Asn 
        595                 600                 605             


Ser Met Arg Asp Leu Leu Ser Tyr Val Arg Asn Tyr Ala Phe His Tyr 
    610                 615                 620                 


Thr Gly Ala Val Asp Leu Lys Glu Glu Tyr Gly Asn Thr Leu Leu Glu 
625                 630                 635                 640 


Asn Ile Tyr Arg Gln Glu Leu Ala Gln Val Asn Arg His Tyr Arg Glu 
                645                 650                 655     


Lys Tyr Tyr Ser Asn Asn Val Pro Val Tyr Tyr Gly Glu Lys Asp Ile 
            660                 665                 670         


Lys Asn Leu Met Glu His Leu Tyr Gln Ser Pro Lys Asn Thr Pro Ala 
        675                 680                 685             


Gln Ile Pro Ala Phe Lys Arg Val Leu Ser Arg Lys Lys Leu Asp Val 
    690                 695                 700                 


Phe Leu Ser Ala Leu Ser Ile Glu Lys Arg Gly Gln Glu Tyr Glu Gly 
705                 710                 715                 720 


Cys Met Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Tyr Asp Phe Ile Lys 
                725                 730                 735     


Arg Gly Asp Leu Lys Lys Met Phe Ile Asn Ala Leu Asn Asn Lys Lys 
            740                 745                 750         


Val Ser Tyr Lys Thr Lys Glu Tyr Trp Ala Lys Lys Asn Phe Gln Glu 
        755                 760                 765             


Arg Ile Glu Ser Phe Thr Asp Val Ser Met Gly Glu Leu Ala Gln Ile 
    770                 775                 780                 


Ile Met Thr Asp Tyr Asn Met Gln Asn Gln Gly Lys Glu Val Leu Pro 
785                 790                 795                 800 


Asn Ala Asp Lys His Lys Glu Glu Ile Tyr Lys His Phe Pro Ile Leu 
                805                 810                 815     


Leu Ala Glu Val Leu Gln Asp Ala Phe Arg Ser Phe Leu Trp Arg Gln 
            820                 825                 830         


Met Gln Glu Lys Gly Ser Val Tyr Ala Phe Leu Lys Glu Pro Phe Gln 
        835                 840                 845             


Glu Asn Glu Lys Ile Asp Glu Glu Asn Phe Cys Asp Val Pro Trp Asn 
    850                 855                 860                 


Cys Lys Ala Phe Glu Gln Val Leu Asp Gly Lys Asn Lys Leu Cys Tyr 
865                 870                 875                 880 


Ala Trp Tyr Val Ala Ala His Phe Val Asn Pro Arg Tyr Leu Asn Leu 
                885                 890                 895     


Leu Ile Gly Ser Ile Lys Asn Tyr Ile Ala Tyr Val His Ser Ile Glu 
            900                 905                 910         


Arg Arg Ala Arg Asp Ser Gly Asn Glu Leu Ala Gly Val Ile Gln Arg 
        915                 920                 925             


Val Phe Arg Gly Lys Ile Glu Val Leu Glu Gln Thr Leu Ser Val Leu 
    930                 935                 940                 


Gly Phe Val Met Ala Leu Ser Gly Arg Val Ser His Cys Phe Ser Asp 
945                 950                 955                 960 


Tyr Phe Glu Gly Thr Asp Lys Leu Ser Ala Glu Glu Gln Tyr Thr Arg 
                965                 970                 975     


Tyr Leu Ala Gly Phe Val Asp Phe Gln Arg Leu Asp Gly Gly Val Lys 
            980                 985                 990         


Asp Leu Gln Lys Phe Cys Ser Lys  Arg Thr Ala Asn Ser  Pro Asn Pro 
        995                 1000                 1005             


Glu Gly  Arg Ile Gly Leu Tyr  Tyr Asp Glu Lys Asn  Pro Ile Leu 
    1010                 1015                 1020             


Asn Arg  Asn Ile Ile Leu Ala  Arg Ile Tyr Gly Asp  Glu Lys Leu 
    1025                 1030                 1035             


Met Ala  Ala Ser Met Phe Lys  Val Glu Leu Gln Glu  Ile Glu Asn 
    1040                 1045                 1050             


Tyr Tyr  Lys Leu Met Ala Glu  Leu Ala Gly Val Phe  Glu Arg Glu 
    1055                 1060                 1065             


Glu Arg  Cys Gly Glu Lys Glu  Gln Lys Lys Leu Ile  Glu Phe Gln 
    1070                 1075                 1080             


His Leu  Lys Asn Arg Val Glu  Leu His Asp Val Met  Lys Leu Ser 
    1085                 1090                 1095             


Glu Ile  Ala Asn Asp Leu Val  Ala Gln Ile Val Ser  Trp Ala Tyr 
    1100                 1105                 1110             


Leu Arg  Glu Arg Asp Leu Met  Tyr Phe Gln Leu Gly  Tyr His Tyr 
    1115                 1120                 1125             


Ile Lys  Leu Phe Tyr Gly Tyr  Asp Lys Glu Gly Trp  Lys His Lys 
    1130                 1135                 1140             


Ile Glu  Leu Lys Lys Gly Glu  Glu Asp Phe Ser Ile  Glu Glu Gly 
    1145                 1150                 1155             


Ala Leu  Leu Tyr Gln Ile Ala  Ala Ile Tyr Thr Phe  Leu Leu Pro 
    1160                 1165                 1170             


Val Tyr  Phe Lys Glu Asp Gly  Lys Trp Lys Ala Gly  Gly Thr Gly 
    1175                 1180                 1185             


Thr Ala  Ala Gly Asn Ala Leu  Glu Gln Phe Lys Lys  Tyr Cys Gly 
    1190                 1195                 1200             


Gly Ser  Tyr Asn Val Tyr Thr  Asp Gly Leu His Leu  Phe Glu Glu 
    1205                 1210                 1215             


Val Asp  Lys Gln His Asp Glu  Met Val Ala Phe Arg  Asn His Ser 
    1220                 1225                 1230             


Asp His  Phe Lys Tyr Tyr Ala  Phe His Asp Met Ser  Ile Leu Asp 
    1235                 1240                 1245             


Met Tyr  Tyr Lys Thr Tyr Asn  Gly Phe Phe Ser Tyr  Asp Arg Lys 
    1250                 1255                 1260             


Leu Gln  Lys Ser Val Ser Phe  Ile Leu Pro Asn Ile  Leu Gln Arg 
    1265                 1270                 1275             


Tyr Ser  Val Ile Ala Arg Ile  Gly Trp Lys Lys Gly  Asp Ser Ser 
    1280                 1285                 1290             


Gly Arg  Phe Thr Ile Thr Leu  Val Ser Asp Asp Phe  Thr Tyr Lys 
    1295                 1300                 1305             


Val Glu  Glu Asn Gly Gln Glu  Arg Lys Val Lys Ile  Pro Val Arg 
    1310                 1315                 1320             


Glu Glu  Lys Phe Leu Gln Gln  Leu Gln Arg Ile Leu  Glu Tyr Lys 
    1325                 1330                 1335             


Ile Ala  Leu Glu 
    1340         


<210>  590
<211>  1093
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  590

Met Arg Gly Glu Ala Asp Glu Ile Phe Gly Arg Tyr Ile Val Tyr Tyr 
1               5                   10                  15      


Asp Thr Glu Thr Glu Lys Glu Lys Arg Asn Asp Gly Leu Lys Glu Glu 
            20                  25                  30          


Leu Phe Glu Gln Leu Glu Ile Thr Lys Asn Asp Asn Ser Leu His Arg 
        35                  40                  45              


Gln Phe Asp Lys Lys Met His Asp Val Leu Leu Ser Gln Phe Lys Met 
    50                  55                  60                  


Ala Ser Arg Lys Ile Asn Glu Glu Phe Pro Glu Glu Lys Ile Asp Ser 
65                  70                  75                  80  


Gly Lys Val Met Ser Lys Glu Glu Ala Val Phe Trp Ile Ser Phe Phe 
                85                  90                  95      


Glu Arg Ser Val Glu Lys Phe Ala Lys Lys Arg Lys Lys Arg Lys Lys 
            100                 105                 110         


Ser Tyr Tyr Glu Cys Asn Arg Ile Cys Ser Met Leu Trp Glu Lys Trp 
        115                 120                 125             


Phe Ser Tyr Ile Ala Val Lys Tyr Ile Glu Leu Gly Lys Ala Val Tyr 
    130                 135                 140                 


Tyr Phe Gly Thr Pro Asn Leu Tyr Ser Lys Leu Lys Phe Asn Glu Glu 
145                 150                 155                 160 


Ile Val Val Gly Ser Val Leu Glu Glu Tyr Thr Asp Gly Leu Thr Ser 
                165                 170                 175     


Phe Asp Tyr Glu Lys Ile Lys Ala Asp Glu Ser Leu Val Arg Asn Ile 
            180                 185                 190         


Ala Thr Ser Val Thr Phe Ala Ala Asn Ala Phe Ala Ala Ala Ala Cys 
        195                 200                 205             


Asn Gln Gln Phe Arg Glu Glu Lys Asp Ser Asn Ser Asp Val Phe Ala 
    210                 215                 220                 


Lys Thr Leu Met Lys Pro Gly Ala Met Arg Asp Gly Ala Met Lys Arg 
225                 230                 235                 240 


Ile Leu Cys Tyr Phe Gly Gly Ser Ser Phe Phe Glu Glu Glu Leu Arg 
                245                 250                 255     


Ser Val Lys Leu Lys Thr Asp Ala Glu Glu Lys Phe Cys Leu Glu Ile 
            260                 265                 270         


Ala Glu His Ile Glu Asn Leu Arg Asn Thr Ser Tyr His Phe Ser Thr 
        275                 280                 285             


Asp Arg Ser Ala Ala Glu Ala Glu Arg Gly Glu Trp Val Leu Lys Ile 
    290                 295                 300                 


Phe Ala Asn Glu Tyr Lys Arg Val Asn Tyr Val Ile Gly Glu Arg Tyr 
305                 310                 315                 320 


Met Ser Asn Asn Val Ala Met Phe Tyr Ser Glu Lys Gln Leu Tyr Arg 
                325                 330                 335     


Met Met Lys Lys Leu Tyr Ala Leu Arg Ile Val Tyr Glu Ala Gln Ile 
            340                 345                 350         


Pro Ala Phe Asn Ser Ile Val Lys Lys Lys Asp Ile Arg Glu Met Ile 
        355                 360                 365             


Asp Ser Lys Trp Arg Asn Gly Asn Lys Lys Asn Phe Asn Ile Ile Tyr 
    370                 375                 380                 


Ala Asp Val Asp Ile Leu Lys Lys Tyr Glu Ser Ser Leu Phe Phe Val 
385                 390                 395                 400 


Leu Lys Glu Ile Tyr Tyr Tyr Gly Phe Leu Arg Glu Asp Asn Leu Leu 
                405                 410                 415     


Glu Arg Phe Thr Glu Ala Val Leu Lys Phe Ser Lys Ser Asn Ile Ile 
            420                 425                 430         


Asp Thr Val Glu Arg Gln Ala Arg Ser Ser Phe Leu Lys Arg Cys Gly 
        435                 440                 445             


Glu Leu Gly Ile Ile Ser Tyr Ser Ser Asp Tyr Asp His Asn Lys Arg 
    450                 455                 460                 


Cys Phe Val Glu Lys Ala Glu Lys Arg Glu Glu Lys Cys Arg Leu Thr 
465                 470                 475                 480 


Phe Gly Gln Val Cys Gln Gln Ile Met Thr Asp Tyr Asn Met Gln Asn 
                485                 490                 495     


Gln Gly Gln Lys Glu Ile Val Ser Val Glu Lys Arg Lys Trp Gln Glu 
            500                 505                 510         


Lys Ser Gly Leu Ala Pro Ile Tyr Glu His Tyr Val Ile Leu Leu Lys 
        515                 520                 525             


Lys Cys Val Arg Asp Ala Phe Glu Ala Tyr Leu Ala Asp Thr Ser Glu 
    530                 535                 540                 


Phe Thr Phe Leu Met Trp Pro Glu Leu Lys Lys Asp Thr Met Lys Lys 
545                 550                 555                 560 


Lys Tyr Val Ser Arg Val Ser Val Asp Glu Phe Ile Asn Gly Met Pro 
                565                 570                 575     


Glu Ile Gly Ile Phe Ser Glu Leu Asn Asp Leu Leu Leu Lys Gly Asn 
            580                 585                 590         


Glu Glu Cys Gln Glu Glu Lys Asp Pro Lys His Asn Met Gln Leu Met 
        595                 600                 605             


Tyr Asp Trp Tyr Ile Ser Ala His Phe Met Asn Ala Lys Gln Leu Asn 
    610                 615                 620                 


Leu Leu Met Gly Asp Leu Lys Ser Tyr Lys Ala Phe Val Asn Asp Ile 
625                 630                 635                 640 


Cys Asn Arg Ala Lys Asn Thr Gly Asn Glu Lys Val Ala Glu Arg Ile 
                645                 650                 655     


Gln Lys Ala Tyr Asp Glu Gln Arg Tyr Ser Asp Ile Leu Met Val Leu 
            660                 665                 670         


Glu Phe Val Ile Arg Phe Val Gly Lys Val Gly Lys Asn Ile Asp Asp 
        675                 680                 685             


Tyr Phe Gly Leu Gly Lys Asn Ala Asp Ala Lys Glu Glu Tyr Ala Glu 
    690                 695                 700                 


Tyr Leu Arg Gln Phe Val Asp Phe Asp Ser Tyr Val Ser Thr Asn Ile 
705                 710                 715                 720 


Ser Asn Lys Pro Asn Lys Asn Gly Leu Leu Glu Phe Cys Gly Asp Ile 
                725                 730                 735     


Ser Ser Gly Ala Gly Ala Val Asn Thr Gly Met Gly Ile Tyr Phe Asp 
            740                 745                 750         


Glu Glu Asn Pro Ile Val Asn Lys Asn Val Ile Tyr Ser Leu Leu Tyr 
        755                 760                 765             


Gly Asp Gly Asn Met Leu Lys Ala Cys Phe Lys Asp Asp Arg Ile Ser 
    770                 775                 780                 


Leu Asn Glu Ile Ile Gly Lys Gln Glu Asp Ser Tyr Tyr Ser Leu Ala 
785                 790                 795                 800 


Lys Ser Leu Thr Asn Ala Phe Arg Asn Gly Lys Cys Glu Thr Val Lys 
                805                 810                 815     


Glu Gln Asn Asp Met Arg Gln Phe Gln Asn Leu Lys Asn Arg Ile Glu 
            820                 825                 830         


Leu Leu Asp Leu Gln Val Tyr Thr Glu Ile Val Asn Asp Phe Ile Ala 
        835                 840                 845             


Gln Met Ile Ser Trp Ala Tyr Leu Arg Glu Arg Asp Leu Leu His Phe 
    850                 855                 860                 


Gln Leu Gly Phe His Tyr Val Arg Leu Phe Phe Thr Asp Tyr Leu Gln 
865                 870                 875                 880 


Asn Ser Arg Val Lys Glu Tyr Asn Glu Leu Ser Arg Leu Asn Ile Thr 
                885                 890                 895     


Lys Gly Ala Ile Leu Tyr Gln Ile Leu Ala Ile Tyr Asp His Glu Leu 
            900                 905                 910         


Pro Ile Leu Lys Ile Asp Ser Lys Lys Gly Ser Ile Glu Lys Val Glu 
        915                 920                 925             


His Gln Thr Pro Gly Pro Cys Val Ile Ala Phe Cys Lys Thr Tyr Gly 
    930                 935                 940                 


Glu Asn Thr Tyr Asn Ala Gly Gln Gln Phe Phe Gly Glu Glu Lys Arg 
945                 950                 955                 960 


Arg Asp Tyr Phe Val Arg Leu Arg Asp Tyr Ile Asp His Met Arg Tyr 
                965                 970                 975     


Tyr Thr Lys His Asp Arg Ser Ile Phe Glu Leu Leu Gly Glu Met Tyr 
            980                 985                 990         


Asn Gly Phe Met Ile Tyr Asp Thr  Lys Leu Lys Lys Ser  Val Ser Phe 
        995                 1000                 1005             


Ile Thr  Lys Asn Ile Leu Glu  Arg Tyr His Val Val  Ala Asn Thr 
    1010                 1015                 1020             


His Met  Lys His Ala Asp Glu  Glu Asn Pro Asp Phe  Met Tyr Thr 
    1025                 1030                 1035             


Ala Glu  Leu Tyr Ser Asp Lys  Tyr Thr Tyr Lys Gly  Ser Phe Lys 
    1040                 1045                 1050             


Tyr Thr  Tyr Tyr Asp Lys Lys  Ala Lys Lys Thr Val  Gly Arg Thr 
    1055                 1060                 1065             


Lys Lys  Ile Met Glu Val Asn  Ser Arg Ser Gly Leu  Phe Ile Glu 
    1070                 1075                 1080             


Leu Leu  Gly Lys Ile Leu Ser  Tyr Lys Arg 
    1085                 1090             


<210>  591
<211>  1425
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  591

Met Lys Leu Ser Lys Val Asp Arg Ile Arg Val Ala Val Gly Lys Thr 
1               5                   10                  15      


Gly Lys Thr Glu Asn Gly Asn Ser Gln Gly Arg Gly Val Leu Tyr Arg 
            20                  25                  30          


Ser Pro Lys Gly Asn Lys Thr Val Ala Val Asp Ala Val Val Glu Glu 
        35                  40                  45              


Arg Ile Arg Asn Ala Asn Arg Leu Tyr Ser Ala Phe Phe Arg Cys Ala 
    50                  55                  60                  


Tyr Pro Glu Glu Pro Glu Arg His Phe Glu Glu Ile Ile Lys Arg Met 
65                  70                  75                  80  


Ala Thr Gly Lys Lys Ser Gly Ala Gln Ile Leu Lys Glu Tyr Ile Gly 
                85                  90                  95      


Tyr Glu Gly Gln Lys Asn Arg Lys Pro Tyr Thr Phe Tyr Val Asn Lys 
            100                 105                 110         


Cys Ala Tyr Arg Pro Ala Gly Lys Glu Leu Gly Gln Val Leu Arg Leu 
        115                 120                 125             


Phe Val Lys Glu Arg Leu Gly Gln Asn Trp Gln Asn Pro Glu Ala Ala 
    130                 135                 140                 


Glu Ala Ala Val Ala Leu Leu Thr Cys Leu Cys Glu Gly Lys Thr Asn 
145                 150                 155                 160 


Arg Tyr Thr Glu Asn Thr Ala Asp Gly Pro Val Leu Thr Glu Leu Ser 
                165                 170                 175     


Glu Gln Thr Val Thr Gln Leu Glu Gln Val Ser Arg Leu Gly Gly Ser 
            180                 185                 190         


Ile Leu Val Pro Lys Thr Glu Arg Leu Glu Thr Ile Val Thr Val Ile 
        195                 200                 205             


Leu Arg Leu Thr Ala Glu Gln Cys Asn Thr Ser Leu Tyr Val Asn Gly 
    210                 215                 220                 


Gly Thr Lys Glu Ala Gln Asp Ala Asp Leu Glu Lys Gln Ile Ala Leu 
225                 230                 235                 240 


Leu Lys Ser Leu Gln Thr Lys Pro Leu Leu Leu Lys Glu Arg Phe Asp 
                245                 250                 255     


Lys Val Thr Lys Gln Thr Ile Arg Asp Glu Gln Lys Leu Ser Glu Phe 
            260                 265                 270         


Ser Tyr Lys Asp Ala Thr Lys Glu Arg Met Glu Ala Val Val Val Arg 
        275                 280                 285             


Met Arg Lys Thr Leu Lys Lys Gly Ala Ser Arg Glu Val Ala Val Glu 
    290                 295                 300                 


Leu Leu Gln Ala Leu Ala Gln Tyr Asp Gly Lys Thr Trp Asp Gly Trp 
305                 310                 315                 320 


Leu Thr Gln Met Leu Glu Thr Glu Ala Ser Lys Lys Lys Leu Lys Asp 
                325                 330                 335     


Phe Ile Leu Ala Val Asn Lys Asp Phe His His Phe His Val Ile Lys 
            340                 345                 350         


Ser Val Lys Asn Thr Ala Val Ala Val Ser His Ser Glu Asp Asn Thr 
        355                 360                 365             


Leu Gln Leu Ser Gly Ala Lys Lys Lys Thr Lys Gly Ala Met Gln Asp 
    370                 375                 380                 


Ala Leu Phe Ala Tyr Ala Gln Ser Glu Glu Ser Ser Asp Glu Thr Leu 
385                 390                 395                 400 


His Arg Ile Lys Arg Ile Leu Phe Thr Tyr Val Leu Gly Gly Arg Gln 
                405                 410                 415     


Asp Asn Thr Leu Arg Leu Thr Glu Lys Thr His Leu Ala Lys Glu Leu 
            420                 425                 430         


Leu Trp Lys Phe Arg Gly Thr Gly Ala Gly Leu Phe Asp Ala Asp Phe 
        435                 440                 445             


Val Pro Glu Glu Glu Arg Ala Gly Glu Ser Gly Arg Lys Ala Gly Ser 
    450                 455                 460                 


Tyr Thr Asp Leu Gly Cys Leu Phe Ala Glu Asp Asp Gly Ile Arg Asn 
465                 470                 475                 480 


Gln Arg Arg Ile Ala Asp Arg Ile Asn Tyr Val Asn Tyr Gly Asn Tyr 
                485                 490                 495     


Leu Arg Met Arg Lys Ala Ala Glu Asp Glu Phe Thr Leu Phe Trp Cys 
            500                 505                 510         


Ala Tyr Ile Lys Asp Tyr Ile Glu Glu Asn Tyr Val Thr Lys Ile Arg 
        515                 520                 525             


Glu Ala Lys Arg Thr Gly Gly Lys Arg Arg Leu Lys Glu Thr Asp Cys 
    530                 535                 540                 


Glu Ala Glu Arg Met Met Glu Lys Cys Trp His Asp Ile Ile Arg Tyr 
545                 550                 555                 560 


Ile Cys Gly Lys Tyr Ile His Ile Gly Lys Ala Val Tyr His Phe Ala 
                565                 570                 575     


Ile Pro Glu Asp Leu Leu Ala Asn Pro Gly Glu Val Arg Ser Phe Gly 
            580                 585                 590         


Asp Val His Ala Lys Tyr Ala Asp Gly Ile Thr Ser Phe Asp Tyr Glu 
        595                 600                 605             


Asp Ile Lys Ala Glu Glu Asn Leu Gln Lys Ser Ile Phe Asn Val Leu 
    610                 615                 620                 


Val Ser Ala Val Ala Asn Tyr Ser Arg Ser Val Val Asp Leu Ser Ser 
625                 630                 635                 640 


Glu Arg Ala Glu Glu Leu Arg Arg Leu Pro Gly Asn Glu Arg Leu Asn 
                645                 650                 655     


Glu Asp Val Leu Met Met Lys Glu Thr His Leu Lys Glu Leu Leu Leu 
            660                 665                 670         


Pro Asp Ala Lys Lys Arg Leu Leu Arg Tyr Phe Gly Gly Tyr Ser Ala 
        675                 680                 685             


Cys Glu Gly Leu Ser Gly Val Thr Ser Glu Glu Leu Ala Trp Glu Met 
    690                 695                 700                 


Arg Thr Val Leu Ser Thr Leu Arg Asn Glu Ser Phe His Tyr Thr Phe 
705                 710                 715                 720 


Gly Lys Lys Lys Lys Leu Asp Tyr Lys Val Ala Lys Gln Leu Trp Met 
                725                 730                 735     


Gln Ala Ile Arg Ala Asn Arg Gln Leu Ile Leu Asp Lys Tyr Tyr Ser 
            740                 745                 750         


Asn Asn Thr Cys Arg Tyr Tyr Ser Pro Asn Ser Ile Lys Ala Leu Ile 
        755                 760                 765             


Glu Gln Gly Tyr Arg Ser Tyr Glu Glu Arg Glu Ala Gln Ile Pro Ala 
    770                 775                 780                 


Phe Lys Thr Val Trp Lys Lys Ala Glu Leu Ala Lys Tyr Leu Ala Asp 
785                 790                 795                 800 


Lys Lys Val Met Pro Ala Glu Ile Ser Gly Glu Glu Lys Glu Arg Val 
                805                 810                 815     


Ile Phe Gln Gly Ala Phe Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg 
            820                 825                 830         


Glu Phe Thr Val Gly Asn Thr Ala Ala Lys Tyr Phe Phe Asp Ala Val 
        835                 840                 845             


Glu Arg Tyr Cys Lys Glu Asn Glu Thr Gly Pro Tyr Lys Asn Pro Ala 
    850                 855                 860                 


Lys Ser Phe Asn Asp Tyr Val Asn Gly Ala Phe Asn Asn Lys Gly Val 
865                 870                 875                 880 


Lys Val Gln Lys Gly Leu Ser Asp Leu Tyr Arg Glu Gly Lys Ile Thr 
                885                 890                 895     


Phe Gly Val Val Cys Gln Thr Ile Met Ala Glu Tyr Thr Gln Gln Asn 
            900                 905                 910         


Glu Lys Ser Glu Gly Glu Ala Ile Tyr Gln His Phe Lys Met Leu Phe 
        915                 920                 925             


Pro Leu Cys Met Arg Lys Gly Phe Gln Lys Tyr Val Glu Glu Lys His 
    930                 935                 940                 


Lys Glu Leu Leu Gln Pro Val Ile Arg Glu Met Gly Ser Arg Glu Asp 
945                 950                 955                 960 


Phe Leu Thr Asn Ile His Ile Gly Cys Phe Asp Asp Phe Cys Arg Glu 
                965                 970                 975     


Asp Gly Met Tyr Glu Tyr Asp Trp Phe Val Val Ala His Leu Ile His 
            980                 985                 990         


Pro Lys Arg Leu Asn Glu Leu Val  Gly Asn Leu Lys Asp  Tyr Met Gln 
        995                 1000                 1005             


Phe Lys  Gln Asp Ile Leu Arg  Arg Ala Asp Tyr Val  Glu Gln Phe 
    1010                 1015                 1020             


Thr Lys  Glu Glu Leu Ala Ala  Met Lys Ala Arg Thr  Glu Glu Lys 
    1025                 1030                 1035             


Leu Gln  Lys Ile Ser Gly Ile  Leu Arg Val Ala Glu  Phe Val Arg 
    1040                 1045                 1050             


Gly Ile  Ala Gly Arg Val Ser  Asn Thr Phe Ser Asp  Tyr Tyr Glu 
    1055                 1060                 1065             


Ser Glu  Glu Ala Tyr Ala Ser  Tyr Leu Glu Gln Tyr  Ile Glu Phe 
    1070                 1075                 1080             


Pro Arg  Ile Lys Gly Ser Thr  Val Phe Glu Ser Phe  Arg Asp Phe 
    1085                 1090                 1095             


Cys Val  Asn Thr Leu Pro Gly  Gly Ala Val Met Asp  Val Tyr Met 
    1100                 1105                 1110             


Asp Glu  Lys Asn Pro Arg Ile  Leu Arg Asn Val Glu  Val Ala Arg 
    1115                 1120                 1125             


Met Tyr  Ala Gly Gly Asp Ile  Gly Leu Arg Thr Arg  Lys Lys Val 
    1130                 1135                 1140             


Thr Ala  Glu Glu Leu Lys Arg  Tyr Tyr Gln Asn Glu  Ala Glu Val 
    1145                 1150                 1155             


Ala Ala  Leu Leu Lys Ala Gly  Leu Cys Ala Thr Ala  Glu Asp Gln 
    1160                 1165                 1170             


Lys Arg  Val Lys Ala Gln Gln  Glu Leu Arg Asn Arg  Ile Thr Leu 
    1175                 1180                 1185             


Thr Asp  Val Thr Glu Ile Gln  Glu Val Ile Asn Asp  Leu Leu Ser 
    1190                 1195                 1200             


Gln Leu  Val Thr Phe Ser Tyr  Phe Arg Glu Arg Asp  Glu Met Tyr 
    1205                 1210                 1215             


Leu Leu  Leu Gly Phe Tyr Tyr  Met Ala Leu Gln Ser  Asp Gly Asp 
    1220                 1225                 1230             


Trp Gly  Glu Glu Leu Arg Val  Phe Asp Gly Lys Lys  Leu Gln Val 
    1235                 1240                 1245             


Glu Asn  Gly Phe Val Leu Tyr  Gln Leu Leu Ser Ala  Phe Thr Tyr 
    1250                 1255                 1260             


Gly Leu  Asn Met Tyr Ser Glu  Ala Ala Pro Asp Gly  Lys Gly Gly 
    1265                 1270                 1275             


Ser Gln  Ala Gly Lys Ile Gly  Glu Phe Ile Lys Ala  His Pro Asn 
    1280                 1285                 1290             


Ser Trp  Asp Arg Ala Leu Arg  Leu Phe Val Asp Asp  Gly Ala Cys 
    1295                 1300                 1305             


Glu Glu  Val Ser Arg Lys Ala  Arg Asn Tyr Val Asp  His Phe Arg 
    1310                 1315                 1320             


Tyr Tyr  Val Lys Pro Asp Arg  Ser Ile Met Asp Leu  Tyr Ala Val 
    1325                 1330                 1335             


Tyr His  Glu Tyr Phe Phe Asp  Tyr Ser Thr Lys Met  Arg Lys Ser 
    1340                 1345                 1350             


Val Leu  Gln Asn Phe Ala Ser  Ile Leu Glu Arg Tyr  Phe Val Leu 
    1355                 1360                 1365             


Thr Lys  Phe Lys Leu Gly Gly  Glu Arg Gly Ala Gln  Thr Leu Glu 
    1370                 1375                 1380             


Ala Glu  Leu Ser Gly Asp Lys  Phe Thr Tyr Lys Leu  Ser Asp Thr 
    1385                 1390                 1395             


Lys Ala  Lys Pro Val Val Leu  Pro Ala Arg Asn Lys  Glu Phe Leu 
    1400                 1405                 1410             


Glu Asn  Leu Lys Asn Glu Leu  Asn Tyr Arg Gln Glu  
    1415                 1420                 1425 


<210>  592
<211>  1425
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  592

Met Lys Leu Ser Lys Val Asp Arg Ile Arg Val Ala Val Gly Lys Thr 
1               5                   10                  15      


Gly Lys Thr Glu Asn Gly Asn Ser Gln Gly Arg Gly Val Leu Tyr Arg 
            20                  25                  30          


Ser Pro Lys Gly Asn Lys Thr Val Ala Val Asp Ala Val Val Glu Glu 
        35                  40                  45              


Arg Ile Arg Asn Ala Asn Arg Leu Tyr Ser Ala Phe Phe Arg Cys Ala 
    50                  55                  60                  


Tyr Pro Glu Glu Pro Glu Arg His Phe Glu Glu Ile Ile Lys Arg Met 
65                  70                  75                  80  


Ala Thr Gly Lys Lys Ser Gly Ala Gln Ile Leu Lys Glu Tyr Ile Gly 
                85                  90                  95      


Tyr Glu Gly Gln Lys Asn Arg Lys Pro Tyr Thr Phe Tyr Val Asn Lys 
            100                 105                 110         


Cys Ala Tyr Arg Pro Ala Gly Lys Glu Leu Gly Gln Val Leu Arg Leu 
        115                 120                 125             


Phe Val Lys Glu Arg Leu Gly Gln Asn Trp Gln Asn Pro Glu Ala Ala 
    130                 135                 140                 


Glu Ala Ala Val Ala Leu Leu Thr Cys Leu Cys Glu Gly Lys Thr Asn 
145                 150                 155                 160 


Arg Tyr Thr Glu Asn Thr Ala Asp Gly Pro Val Leu Thr Glu Leu Ser 
                165                 170                 175     


Glu Gln Thr Val Thr Gln Leu Glu Gln Val Ser Arg Leu Gly Gly Ser 
            180                 185                 190         


Ile Leu Val Pro Lys Thr Glu Arg Leu Glu Thr Ile Val Thr Val Ile 
        195                 200                 205             


Leu Arg Leu Thr Ala Glu Gln Cys Asn Thr Ser Leu Tyr Val Asn Gly 
    210                 215                 220                 


Gly Thr Lys Glu Ala Gln Asp Ala Asp Leu Glu Lys Gln Ile Ala Leu 
225                 230                 235                 240 


Leu Lys Ser Leu Gln Thr Lys Pro Leu Leu Leu Lys Glu Arg Phe Asp 
                245                 250                 255     


Lys Val Thr Lys Gln Thr Ile Arg Asp Glu Gln Lys Leu Ser Glu Phe 
            260                 265                 270         


Ser Tyr Lys Asp Ala Thr Lys Glu Arg Met Glu Ala Val Val Val Arg 
        275                 280                 285             


Met Arg Lys Thr Leu Lys Lys Gly Ala Ser Arg Glu Val Ala Val Glu 
    290                 295                 300                 


Leu Leu Gln Ala Leu Ala Gln Tyr Asp Gly Lys Thr Trp Asp Gly Trp 
305                 310                 315                 320 


Leu Thr Gln Met Leu Glu Thr Glu Ala Ser Lys Lys Lys Leu Lys Asp 
                325                 330                 335     


Phe Ile Leu Ala Val Asn Lys Asp Phe His His Phe His Val Ile Lys 
            340                 345                 350         


Ser Val Lys Asn Thr Ala Val Ala Val Ser His Ser Glu Asp Asn Thr 
        355                 360                 365             


Leu Gln Leu Ser Gly Ala Lys Lys Lys Thr Lys Gly Ala Met Gln Asp 
    370                 375                 380                 


Ala Leu Phe Ala Tyr Ala Gln Ser Glu Glu Ser Ser Asp Glu Thr Leu 
385                 390                 395                 400 


His Arg Ile Lys Arg Ile Leu Phe Thr Tyr Val Leu Gly Gly Arg Gln 
                405                 410                 415     


Asp Asn Thr Leu Arg Leu Thr Glu Lys Thr His Leu Ala Lys Glu Leu 
            420                 425                 430         


Leu Trp Lys Phe Arg Gly Thr Gly Ala Gly Leu Phe Asp Ala Asp Phe 
        435                 440                 445             


Val Pro Glu Glu Glu Arg Ala Gly Glu Ser Gly Arg Lys Ala Gly Ser 
    450                 455                 460                 


Tyr Thr Asp Leu Gly Cys Leu Phe Ala Glu Asp Asp Gly Ile Arg Asn 
465                 470                 475                 480 


Gln Arg Arg Ile Ala Asp Arg Ile Asn Tyr Val Asn Tyr Gly Asn Tyr 
                485                 490                 495     


Leu Arg Met Arg Lys Ala Ala Glu Asp Glu Phe Thr Leu Phe Trp Cys 
            500                 505                 510         


Ala Tyr Ile Lys Asp Tyr Ile Glu Glu Asn Tyr Val Thr Lys Ile Arg 
        515                 520                 525             


Glu Ala Lys Arg Thr Gly Gly Lys Arg Arg Leu Lys Glu Thr Asp Cys 
    530                 535                 540                 


Glu Ala Glu Arg Met Met Glu Lys Cys Trp His Asp Ile Ile Arg Tyr 
545                 550                 555                 560 


Ile Cys Gly Lys Tyr Ile His Ile Gly Lys Ala Val Tyr His Phe Ala 
                565                 570                 575     


Ile Pro Glu Asp Leu Leu Ala Asn Pro Gly Glu Val Arg Ser Phe Gly 
            580                 585                 590         


Asp Val His Ala Lys Tyr Ala Asp Gly Ile Thr Ser Phe Asp Tyr Glu 
        595                 600                 605             


Asp Ile Lys Ala Glu Glu Asn Leu Gln Lys Ser Ile Phe Asn Val Leu 
    610                 615                 620                 


Val Ser Ala Val Ala Asn Tyr Ser Arg Ser Val Val Asp Leu Ser Ser 
625                 630                 635                 640 


Glu Arg Ala Glu Glu Leu Arg Arg Leu Pro Gly Asn Glu Arg Leu Asn 
                645                 650                 655     


Glu Asp Val Leu Met Met Lys Glu Thr His Leu Lys Glu Leu Leu Leu 
            660                 665                 670         


Pro Asp Ala Lys Lys Arg Leu Leu Arg Tyr Phe Gly Gly Tyr Ser Ala 
        675                 680                 685             


Cys Glu Gly Leu Ser Gly Val Thr Ser Glu Glu Leu Ala Trp Glu Met 
    690                 695                 700                 


Arg Thr Val Leu Ser Thr Leu Arg Asn Glu Ser Phe His Tyr Thr Phe 
705                 710                 715                 720 


Gly Lys Lys Lys Lys Leu Asp Tyr Lys Val Ala Lys Gln Leu Trp Met 
                725                 730                 735     


Gln Ala Ile Arg Ala Asn Arg Gln Leu Ile Leu Asp Lys Tyr Tyr Ser 
            740                 745                 750         


Asn Asn Thr Cys Arg Tyr Tyr Ser Pro Asn Ser Ile Lys Ala Leu Ile 
        755                 760                 765             


Glu Gln Gly Tyr Arg Ser Tyr Glu Glu Arg Glu Ala Gln Ile Pro Ala 
    770                 775                 780                 


Phe Lys Thr Val Trp Lys Lys Ala Glu Leu Ala Lys Tyr Leu Ala Asp 
785                 790                 795                 800 


Lys Lys Val Met Pro Ala Glu Ile Ser Gly Glu Glu Lys Glu Arg Val 
                805                 810                 815     


Ile Phe Gln Gly Ala Phe Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg 
            820                 825                 830         


Glu Phe Thr Val Gly Asn Thr Ala Ala Lys Tyr Phe Phe Asp Ala Val 
        835                 840                 845             


Glu Arg Tyr Cys Lys Glu Asn Glu Thr Gly Pro Tyr Lys Asn Pro Ala 
    850                 855                 860                 


Lys Ser Phe Asn Asp Tyr Val Asn Gly Ala Phe Asn Asn Lys Gly Val 
865                 870                 875                 880 


Lys Val Gln Lys Gly Leu Ser Asp Leu Tyr Arg Glu Gly Lys Ile Thr 
                885                 890                 895     


Phe Gly Val Val Cys Gln Thr Ile Met Ala Glu Tyr Thr Gln Gln Asn 
            900                 905                 910         


Glu Lys Ser Glu Gly Glu Ala Ile Tyr Gln His Phe Lys Met Leu Phe 
        915                 920                 925             


Pro Leu Cys Met Arg Lys Gly Phe Gln Lys Tyr Val Glu Glu Lys His 
    930                 935                 940                 


Lys Glu Leu Leu Gln Pro Val Ile Arg Glu Met Gly Ser Arg Glu Asp 
945                 950                 955                 960 


Phe Leu Thr Asn Ile His Ile Gly Cys Phe Asp Asp Phe Cys Arg Glu 
                965                 970                 975     


Asp Gly Met Tyr Glu Tyr Asp Trp Phe Val Val Ala His Leu Ile His 
            980                 985                 990         


Pro Lys Arg Leu Asn Glu Leu Val  Gly Asn Leu Lys Asp  Tyr Met Gln 
        995                 1000                 1005             


Phe Lys  Gln Asp Ile Leu Arg  Arg Ala Asp Tyr Ala  Glu Gln Phe 
    1010                 1015                 1020             


Thr Asn  Glu Glu Leu Ala Ala  Met Lys Ala Arg Thr  Glu Glu Lys 
    1025                 1030                 1035             


Leu Gln  Lys Ile Ser Gly Ile  Leu Arg Val Ala Glu  Phe Val Arg 
    1040                 1045                 1050             


Gly Ile  Ala Gly Arg Val Ser  Asn Thr Phe Ser Asp  Tyr Tyr Glu 
    1055                 1060                 1065             


Ser Glu  Glu Ala Tyr Ala Ser  Tyr Leu Glu Gln Tyr  Ile Glu Phe 
    1070                 1075                 1080             


Pro Arg  Ile Lys Gly Ser Thr  Val Phe Glu Ser Phe  Arg Asp Phe 
    1085                 1090                 1095             


Cys Val  Asn Thr Leu Pro Gly  Gly Ala Val Met Asp  Val Tyr Met 
    1100                 1105                 1110             


Asp Glu  Lys Asn Pro Arg Ile  Leu Arg Asn Val Glu  Val Ala Arg 
    1115                 1120                 1125             


Met Tyr  Ala Gly Gly Asp Ile  Gly Leu Arg Thr Arg  Lys Lys Val 
    1130                 1135                 1140             


Thr Ala  Glu Glu Leu Lys Arg  Tyr Tyr Gln Asn Glu  Ala Glu Val 
    1145                 1150                 1155             


Ala Ala  Leu Leu Lys Ala Gly  Leu Cys Ala Thr Ala  Glu Asp Gln 
    1160                 1165                 1170             


Lys Arg  Val Lys Ala Gln Gln  Glu Leu Arg Asn Arg  Ile Thr Leu 
    1175                 1180                 1185             


Thr Asp  Val Thr Glu Ile Gln  Glu Val Ile Asn Asp  Leu Leu Ser 
    1190                 1195                 1200             


Gln Leu  Val Thr Phe Ser Tyr  Phe Arg Glu Arg Asp  Glu Met Tyr 
    1205                 1210                 1215             


Leu Leu  Leu Gly Phe Tyr Tyr  Met Ala Leu Gln Ser  Asp Gly Asp 
    1220                 1225                 1230             


Trp Gly  Glu Glu Leu Arg Val  Phe Asp Gly Lys Lys  Leu Gln Val 
    1235                 1240                 1245             


Glu Asn  Gly Phe Val Leu Tyr  Gln Leu Leu Ser Ala  Phe Thr Tyr 
    1250                 1255                 1260             


Gly Leu  Asn Met Tyr Ser Glu  Ala Ala Pro Asp Gly  Lys Gly Gly 
    1265                 1270                 1275             


Ser Gln  Ala Gly Lys Ile Gly  Glu Phe Ile Lys Ala  His Pro Asn 
    1280                 1285                 1290             


Ser Trp  Asp Arg Ala Leu Arg  Leu Phe Val Asp Asp  Gly Ala Cys 
    1295                 1300                 1305             


Glu Glu  Val Ser Arg Lys Ala  Arg Asn Tyr Val Asp  His Phe Arg 
    1310                 1315                 1320             


Tyr Tyr  Val Lys Pro Asp Arg  Ser Ile Met Asp Leu  Tyr Ala Val 
    1325                 1330                 1335             


Tyr His  Glu Tyr Phe Phe Asp  Tyr Ser Thr Lys Met  Arg Lys Ser 
    1340                 1345                 1350             


Val Leu  Gln Asn Phe Ala Ser  Ile Leu Glu Arg Tyr  Phe Val Leu 
    1355                 1360                 1365             


Thr Lys  Phe Lys Leu Gly Gly  Glu Arg Gly Ala Gln  Thr Leu Glu 
    1370                 1375                 1380             


Ala Glu  Leu Ser Gly Asp Lys  Phe Thr Tyr Lys Leu  Ser Asp Thr 
    1385                 1390                 1395             


Lys Ala  Lys Pro Val Val Leu  Pro Ala Arg Asn Lys  Glu Phe Leu 
    1400                 1405                 1410             


Glu Asn  Leu Lys Asn Glu Leu  Asn Tyr Arg Gln Glu  
    1415                 1420                 1425 


<210>  593
<211>  1330
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  593

Met Lys Arg Glu Lys Asn Ile Thr Ile Met Lys Ile Ser Lys Val Asn 
1               5                   10                  15      


His Arg Arg Thr Ala Val Ala Leu Asn Gly Asp Lys Ser Glu Leu Gly 
            20                  25                  30          


Gly Ile Leu Tyr Glu Ala Pro Val Gln Lys Asp Lys Asn Gly Asn Tyr 
        35                  40                  45              


Asn Asp Val Ile Ala Glu Thr Gly Lys Val Val Asn Glu Ala Leu Asp 
    50                  55                  60                  


Lys Lys Ser Arg Leu Tyr Thr Pro Phe Asn Asn Gln Lys Val Ile Ile 
65                  70                  75                  80  


Asp Lys Asn Leu Gln Arg Tyr Ala Asn Asn Leu Lys Arg Cys Tyr Ile 
                85                  90                  95      


Asn Phe Val Lys Gln Tyr Val Asn Asn Lys Ser Phe Asn Tyr Lys Ala 
            100                 105                 110         


Met Gln Phe Ile Pro Asp Ile Gln Asn Leu Lys Thr Asn Asp Ala Val 
        115                 120                 125             


Asn Tyr Arg Thr Asp Arg Asp Asn Val Tyr Asn Lys Asn Lys Tyr Tyr 
    130                 135                 140                 


Asp Lys Gln Thr Lys Ser Lys Ser Lys Lys Phe Ile Tyr Glu Lys Ile 
145                 150                 155                 160 


Val Ile Pro Gln Asn Glu Gln Asn Ile Val Ile Ser Ala Leu Val Asn 
                165                 170                 175     


Cys Ser Leu Arg Lys Ser Leu Arg Lys Asp Val Ser Tyr Lys Thr Lys 
            180                 185                 190         


Ser Gly Glu Ile Lys Thr Tyr Asn Leu Pro Glu Leu Val Lys Lys Ser 
        195                 200                 205             


Met Arg Phe Tyr Cys Leu Glu Gly Gln Arg Glu Pro Asp Glu Lys Glu 
    210                 215                 220                 


Lys Tyr Glu Met Tyr Ile Leu Phe Ser Tyr Met Lys Glu Asp Lys Arg 
225                 230                 235                 240 


Thr Lys Asn Thr Asp Leu Leu Val Lys Ser Ile Ser Asn Gln Asn Thr 
                245                 250                 255     


Lys Val Lys Val Glu Asp Ile Asp Gly Asn Lys Leu Leu Lys Leu Ser 
            260                 265                 270         


Ile Ala Asp Thr Lys Lys Lys Pro Leu Trp Glu Tyr Leu Ile Lys Tyr 
        275                 280                 285             


Ala Asp Ser Ser Arg Gln Arg Glu Leu Met Tyr Asp Ile Arg Lys Lys 
    290                 295                 300                 


Ile Ile Leu Tyr Val Ala Gly Ile Glu Glu Tyr Glu Asn Ile Lys Glu 
305                 310                 315                 320 


Asp Ser Gly Leu Ser Lys Val Ser Trp Ser Lys Tyr Asn Ile Ser Asp 
                325                 330                 335     


Asn Lys Met Phe Leu Asp Ile Asn Ser Cys Thr Asp Lys Arg Lys Gln 
            340                 345                 350         


Asn Leu Glu Ile Lys Ile Arg Glu Ala Asn Ile Glu His Tyr Arg Asn 
        355                 360                 365             


Ala Ser Ser Lys Leu Cys Asp Asp Glu Ser Ile Phe Trp Phe Gln His 
    370                 375                 380                 


Phe Glu Gly Val Ile Glu Thr Leu Phe Ser Lys Lys Ser Lys Ile Ser 
385                 390                 395                 400 


Glu Glu Arg Leu Gly Cys Ala Tyr Ile Cys Asp Tyr Leu Trp Lys Asp 
                405                 410                 415     


Phe Leu Ser Tyr Leu Ala Ala Lys Tyr Ile Asp Leu Gly Lys Gly Val 
            420                 425                 430         


Tyr His Phe Thr Met Lys Asp Lys Leu Asp Met Leu Asn Lys Asn Glu 
        435                 440                 445             


Ala Val Thr Asp Leu Arg Phe Gly Ile Val Ser Glu Lys Tyr Glu Lys 
    450                 455                 460                 


Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Glu Leu 
465                 470                 475                 480 


Asp Arg Asn Ile Ala Ala Tyr Val Thr Phe Ala Ala Asp Ile Phe Ala 
                485                 490                 495     


Lys Ser Val Ile Lys Ser Asp Tyr Arg Thr Lys Lys Asp Asn Asn Ser 
            500                 505                 510         


Asp Val Leu Gln Tyr Ser Asp Lys Glu Phe Arg Asn Ser Glu Val Ile 
        515                 520                 525             


Arg Asp Asn Ala Glu Lys Asn Ile Leu Gln Tyr Trp Gly Gly Tyr Ser 
    530                 535                 540                 


Arg Trp Gly Thr Glu Asn Ser Lys Leu Pro Glu Asn Asn Lys Val Ser 
545                 550                 555                 560 


Asp Phe Gly Lys Leu Asp Val Ser Asp Leu Cys Ile Asp Ile Lys Lys 
                565                 570                 575     


His Leu Ala Gly Ile Arg Asn Ser Ser Val His Tyr Thr Thr Lys Ile 
            580                 585                 590         


Lys Asn Glu Ser Ala Ala Asp Gly Ser Asn Val Lys Ile Leu Phe Glu 
        595                 600                 605             


Lys Asp Leu Ala Asp Ile Asn Ile Ile Tyr Ala Asp Lys Tyr Tyr Ser 
    610                 615                 620                 


Asn Asn Val Trp Met Phe Tyr Ser Leu Glu Asp Ile Asn Lys Leu Ile 
625                 630                 635                 640 


Ala Phe Leu Tyr Lys Glu Lys Arg Val Ile Arg Gln Val Gln Ile Pro 
                645                 650                 655     


Ser Phe Ser Arg Ile Leu Lys Arg Lys Ala Met Gln Asp Val Ile Asn 
            660                 665                 670         


Glu Ile Phe Lys Asp Asp Phe Asp Glu Asn Ile Val Asn Pro Glu Leu 
        675                 680                 685             


Lys Glu Lys Tyr Arg Asn Ser Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
    690                 695                 700                 


Tyr Asn Ala Phe Ile Ile Gln Pro Glu Leu Lys Glu Lys Phe Lys Asp 
705                 710                 715                 720 


Lys Ile Lys Thr Met Lys Ser Glu Leu Tyr Asn Lys Leu Lys Thr Ile 
                725                 730                 735     


Asp Lys Lys Glu Tyr Lys Ala Leu Tyr Cys Met Leu Ser Asn Glu Glu 
            740                 745                 750         


Ser Ala Leu Lys Asn Phe Ala Asp Arg Ile Tyr Ser Val Asp Gly Asp 
        755                 760                 765             


Asn Val Ser Phe Ala Asp Ile Cys Lys Ile Leu Met Thr Asp Tyr Asn 
    770                 775                 780                 


Met Gln Asn Gln Glu Lys Lys Asn Ile Glu Ser Met Glu Gln Lys Lys 
785                 790                 795                 800 


Lys Asn Lys Gly Lys Asp Glu Asn Tyr Lys His Phe Pro Leu Leu Leu 
                805                 810                 815     


His Lys Val Leu Lys Glu Leu Phe Ile Glu Tyr Leu Lys Gln Thr His 
            820                 825                 830         


Glu Leu Glu Phe Leu Arg Asn Asn Ile Cys Ile Lys Ser Asp Val Thr 
        835                 840                 845             


Met Glu Ser Phe Glu Ser Gln Ile Lys Gly Val Glu Ile Tyr Lys Asp 
    850                 855                 860                 


Leu Lys Glu Lys Ile Asp Lys Asn Asn Ser Leu Leu Asp Trp Tyr Val 
865                 870                 875                 880 


Ile Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asn 
                885                 890                 895     


Ile Lys Asn Tyr Ile Gln Phe Ala Thr Asn Ile Asp Lys Arg Ala Glu 
            900                 905                 910         


Ser Val Lys Asn Leu Thr Glu Ser Gly Met Val Lys Arg Ile Gln Tyr 
        915                 920                 925             


Tyr Asp Asp Ile Val Arg Thr Leu Glu Phe Ser Ala Gln Tyr Ile Gly 
    930                 935                 940                 


Lys Ile Ser Asn Asn Ile Asn Asp Tyr Phe Asn Ser Glu Asp Glu Tyr 
945                 950                 955                 960 


Val Ser Phe Leu Ser Lys Tyr Val Gly Phe Ile Asn Asp Lys Ser Glu 
                965                 970                 975     


Asp Val Leu Thr Glu Leu Lys Asp Phe Cys Arg Glu Lys Ile Asn Asn 
            980                 985                 990         


Gly Ser Gln Ile Ile Gly Ile Tyr  Tyr Gly Gly Asp Asn  Val Ile Ile 
        995                 1000                 1005             


Asn Arg  Asn Val Ile Tyr Ala  Gln Met Tyr Ser Asn  Ala Glu Val 
    1010                 1015                 1020             


Phe Ser  Asn Ile Tyr Lys Lys  Val Thr Lys Asn Asp  Ile Ile Asn 
    1025                 1030                 1035             


Tyr Tyr  Glu Lys Gln Asn Asp  Leu Lys Asp Val Phe  Lys Ser Gly 
    1040                 1045                 1050             


Val Cys  Gln Asn Glu Gly Glu  Gln Arg Ser Leu Cys  Glu Phe Gln 
    1055                 1060                 1065             


Gln Leu  Lys Asn Arg Ile Glu  Leu Thr Glu Leu Ser  Thr Tyr Ala 
    1070                 1075                 1080             


Asp Met  Val Asn Asp Phe Met  Ala Gln Phe Val Glu  Trp Ala Tyr 
    1085                 1090                 1095             


Leu Arg  Glu Arg Asp Leu Met  Tyr Phe Gln Leu Gly  Ile His Tyr 
    1100                 1105                 1110             


Ile Arg  Leu Phe Tyr Ser Asp  Asn Val Leu Asp Glu  Lys Tyr His 
    1115                 1120                 1125             


Lys Leu  Arg Asp Asn Val Ile  Asp Ile Glu Glu Gly  Ala Leu Leu 
    1130                 1135                 1140             


Tyr Gln  Ile Val Ala Met Tyr  Asp Tyr Glu Leu Arg  Ile Phe Glu 
    1145                 1150                 1155             


Thr Asp  Asn Ser Gly Asn Ala  Lys Arg Ile Gly Gln  Gly Gly Pro 
    1160                 1165                 1170             


Gly Lys  Ser Ile Pro Val Phe  Leu Lys Lys Tyr Cys  Asn Gly Thr 
    1175                 1180                 1185             


Asp Val  Tyr Glu Cys Gly Leu  Glu Leu Phe Glu Asp  Ile Asn Gln 
    1190                 1195                 1200             


His Glu  His Ile Ile Arg Phe  Arg Asn Asp Ile Ala  His Met Arg 
    1205                 1210                 1215             


Tyr Met  Ser Asn Gln Ala Met  Asn Ile Met Ser Ile  Val Ser Asn 
    1220                 1225                 1230             


Ile Tyr  Lys Ser Phe Phe Val  Tyr Asp Thr Lys Leu  Lys Lys Ser 
    1235                 1240                 1245             


Ile Ser  Leu Val Phe Lys Asn  Ile Leu Met Arg Tyr  Gly Val Ile 
    1250                 1255                 1260             


Ala Asp  Leu Val Phe Ser Tyr  Asn Asn Lys Asn Gln  Ser Ile Lys 
    1265                 1270                 1275             


Asp Asp  Met Asn Ile Asn Ile  Ile Asn Ile Lys Asn  Leu Lys Ser 
    1280                 1285                 1290             


Asp Lys  Tyr Val Tyr Lys Ile  Val Asn Glu Asp Ile  Val Lys Gln 
    1295                 1300                 1305             


Val Glu  Ile Glu Ile Arg Asn  Gln Val Phe Leu Glu  Gln Leu His 
    1310                 1315                 1320             


Lys Leu  Leu Tyr Phe Ser Arg  
    1325                 1330 


<210>  594
<211>  1358
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  594

Met Lys Ile Ser Lys Glu Gly His Lys Arg Met Ser Val Thr Leu Lys 
1               5                   10                  15      


Lys Glu Asn Met Gln Lys Asn Asp Ala Asp Lys Thr Lys Gly Gln Ile 
            20                  25                  30          


Leu Pro Leu Pro Glu Gly Glu Gly Leu Glu Lys Tyr Ile Gln Lys Arg 
        35                  40                  45              


Val Ala Asn Thr Gln Lys Leu Tyr Lys Val Leu Gly Pro Ser Ala Val 
    50                  55                  60                  


Ser Val Pro Asn Glu Lys Glu Lys Glu Thr Ile Asp Cys Phe Asn Asp 
65                  70                  75                  80  


Phe Ile Lys Asn Ile Ile Leu Lys Asn Val Asn Thr Gln Pro Ala Glu 
                85                  90                  95      


Lys Arg Asn Arg Asn Ala Val Glu Tyr Met Lys Thr Lys Gly Asn Val 
            100                 105                 110         


Asn Thr Val Phe Ile Asp Val Asp Arg Lys Cys Ile His Lys Leu Val 
        115                 120                 125             


Pro Leu His Leu Arg Gly Thr Leu Lys Lys Tyr Val Lys Ile Glu Lys 
    130                 135                 140                 


Asp Gly Gln Arg Ile Glu Val Tyr Ile Pro Asp Val Ile Glu Lys Leu 
145                 150                 155                 160 


Val Phe Ala Val Ala His Gly Thr Gln Phe Asp His Leu Ile Ala Glu 
                165                 170                 175     


Ile Glu Glu Glu Glu Leu Ile Val Cys Leu His Met Ile Phe Lys Asp 
            180                 185                 190         


Tyr Thr Lys Glu Asp Ile Ile Ala Asn Thr Ala Lys Ser Ile Glu Lys 
        195                 200                 205             


Gln Asp Val Lys Val Gln Val Leu Gly Thr Gly Glu Asp Ala Arg Leu 
    210                 215                 220                 


Gln Leu Ala Ser Ala Asp Asn Glu Lys Lys Lys Tyr Ile Phe Leu Phe 
225                 230                 235                 240 


Leu Lys Lys Phe Ala Cys Ala Val Ser Glu Lys Glu Arg Asn Asp Leu 
                245                 250                 255     


Leu Arg Glu Phe Arg Glu Leu Leu Val Leu Phe Tyr Cys Gly Thr Ala 
            260                 265                 270         


Ala Tyr Glu Glu Val Lys Glu Trp Lys Asn Gly Ile Pro Ile Trp Asp 
        275                 280                 285             


Phe Asp Phe Leu Ser Lys Met Val Ser Asp Ile Ser Trp Phe Phe Ser 
    290                 295                 300                 


Gln Glu Cys Ser Glu Lys Leu Met Glu Arg Glu Gln Leu Arg Arg Glu 
305                 310                 315                 320 


Lys Asp Lys Asp Lys Lys Arg Gln Asn Lys Ser Lys Ile Lys Asp Ile 
                325                 330                 335     


Asp Val Glu Val Lys Gly Ile Leu Ala Asn Leu Ile Thr Glu Arg Tyr 
            340                 345                 350         


Arg Glu Ser Ile Lys Leu Leu Gln Ser Leu Leu Gly Glu Glu Glu Tyr 
        355                 360                 365             


Lys Glu Lys Cys Phe Trp Leu Glu Tyr Ile Glu Asn Asp Ala Glu Lys 
    370                 375                 380                 


Ile Leu Cys Ser Lys Lys Ala Leu Thr Glu Asn Lys Leu Asp Thr Val 
385                 390                 395                 400 


Trp Leu Cys Asn Asn Thr Trp Arg Asn Phe Leu Ser Phe Leu Cys Ser 
                405                 410                 415     


Lys Ala Val Asp Met Gly Lys Ala Val Tyr His Phe Ala Met Pro Asp 
            420                 425                 430         


Leu Glu Gln Leu Glu Ser Gly Glu Pro Ile Lys Ala Gly Met Ile Lys 
        435                 440                 445             


Pro Gln Phe Gln Gln Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys 
    450                 455                 460                 


Ala Glu Glu Asn Leu Glu Arg Ser Phe Met Thr Ala Ile Ser Phe Ala 
465                 470                 475                 480 


Leu Asn Asn Phe Ser Ala Ala Val Cys Pro Pro Glu Thr Tyr Glu Lys 
                485                 490                 495     


Lys Asn Lys Glu Asp Val Leu Phe Met Gly Asp Lys Asp Leu Arg Glu 
            500                 505                 510         


Glu Met Tyr Pro Asn Ala Ser Trp His Ile Met Gln Tyr Phe Gly Gly 
        515                 520                 525             


Ile Ser Gln Trp Lys Asp Ser Cys Phe Glu Asp Ile Val Met Leu Glu 
    530                 535                 540                 


Asp Ala Asp Leu Asn Glu Glu Phe Val Leu Glu Val Lys Gly Ala Met 
545                 550                 555                 560 


Ser Leu Ile Arg Asn Ser Ala Phe His Tyr Ala Ala Ser Ala Ala Gln 
                565                 570                 575     


Gly Thr Leu Asp Lys Gly Ser Tyr Leu Val Glu Leu Phe Glu Arg Glu 
            580                 585                 590         


Arg Asp Asn Leu Gly Ser Lys Tyr Arg Lys Lys Tyr Val Ser Asn Asn 
        595                 600                 605             


Val Pro Met Phe Tyr Lys Val Glu Asp Ile Asp Arg Leu Met His Cys 
    610                 615                 620                 


Leu Tyr Gly Glu Gln Lys Val Leu Glu Ser Gln Ile Pro Ser Phe Arg 
625                 630                 635                 640 


Asn Val Ile Thr Arg Lys Ser Leu Pro Asp Ile Ile Val Lys Phe Val 
                645                 650                 655     


Lys Gly Lys Pro Tyr Gly Lys Ile Gln Lys Asn Val Glu Thr Ala Ser 
            660                 665                 670         


Lys Phe His Ser Ala Leu Tyr Phe Val Leu Lys Glu Ile Tyr Tyr Asn 
        675                 680                 685             


Gly Phe Leu Gln Glu Glu Asn Leu Met Glu Arg Phe Met Val Ser Phe 
    690                 695                 700                 


Asn Asn Glu Trp Asn Lys Val Lys Glu Ser Ser Gly Asn Lys Lys Lys 
705                 710                 715                 720 


Glu Ala Ala Met Lys Asp Phe Ser Arg Arg Ile Ser Glu Leu Gln Gln 
                725                 730                 735     


Asn Gly Lys Arg Leu Thr Phe Gly Glu Leu Cys Gln Ala Ile Met Thr 
            740                 745                 750         


Asp Tyr Asn Met Gln Asn Asn Gln Lys Lys Val Arg Leu Asn Lys Lys 
        755                 760                 765             


Asp Asn Leu Pro Asp Glu Lys Tyr Lys His Phe Lys Met Leu Leu Leu 
    770                 775                 780                 


Val Cys Leu Arg Glu Thr Phe Ile Asp Tyr Leu Lys Lys Asp Val Ala 
785                 790                 795                 800 


Gly Glu Lys Phe Asp Cys Ala Phe Leu Arg Glu Pro Gly Leu Lys Glu 
                805                 810                 815     


Asn Val Tyr Glu Asn Leu Thr Glu Glu Gln Phe Cys Lys Gly Trp Lys 
            820                 825                 830         


Ile Asp Arg Tyr Lys Asn Leu Ile Asn Glu Asn Gly Gln Tyr Asp Ser 
        835                 840                 845             


Trp Leu Ile Ser Trp Phe Ile Leu Ala His Phe Met Thr Pro Lys His 
    850                 855                 860                 


Leu Asn His Leu Cys Gly Glu Ile Lys Ser Tyr Leu Ser Tyr Val His 
865                 870                 875                 880 


Asn Ile Glu Arg Arg Arg Phe Asp Ala Met Arg Val Gln Val Glu Glu 
                885                 890                 895     


Asn Lys Glu Lys Arg Gln Lys Tyr Glu Gln Val Leu Glu Ile Leu Asn 
            900                 905                 910         


Leu Ala Ala Glu Tyr Cys Gly Gln Val Ser Asn Glu Arg Thr Asp Tyr 
        915                 920                 925             


Tyr Glu Ser Glu Glu Glu Tyr Ala Arg His Ile Ser Met Tyr Val Ala 
    930                 935                 940                 


Phe Glu Glu Lys Asn Ser Glu Arg Pro Leu Glu Glu Gln Leu Tyr Gly 
945                 950                 955                 960 


Phe Cys Asn Gln Lys Ala Asp Gly Gly Pro Ala Ser Arg Ile Gly Ile 
                965                 970                 975     


Phe Tyr Asp Gly Glu Asn Pro Ile Leu Asn Arg Asn Val Val Leu Thr 
            980                 985                 990         


Lys Leu Tyr Gly Ala Glu Arg Leu  Leu Ser Glu Cys Leu  Gln Lys Glu 
        995                 1000                 1005             


Arg Val  Thr Lys Ala Glu Ile  Glu Lys His Tyr Lys  His Thr Lys 
    1010                 1015                 1020             


Lys Leu  Glu Ala Val Phe Lys  Tyr Gly Thr Cys Lys  Asn Gln Glu 
    1025                 1030                 1035             


Gln Glu  Gln Glu Arg Arg Thr  Tyr Gln Gln Gln Lys  Asn Arg Ile 
    1040                 1045                 1050             


Glu Leu  Val Asp Ile Leu Lys  Tyr Ser Asp Leu Leu  Asn Asp Phe 
    1055                 1060                 1065             


Met Ser  Gln Leu Ile Ser Trp  Cys Tyr Leu Arg Glu  Arg Asp Arg 
    1070                 1075                 1080             


Met Tyr  Phe Gln Ile Gly Leu  His Tyr Ile Arg Leu  Tyr Tyr Gly 
    1085                 1090                 1095             


Glu Asn  Leu Val Glu Lys Asn  Ser Lys Phe Arg Val  Leu Gln Ser 
    1100                 1105                 1110             


Lys Glu  Ala Lys Ala Gly Glu  Lys Lys Gly Ile Asn  Leu Val Asp 
    1115                 1120                 1125             


Gly Ala  Val Leu Tyr Gln Ile  Ala Ala Ile Tyr Thr  Tyr Glu Tyr 
    1130                 1135                 1140             


Pro Val  Tyr Ala Leu Asp Glu  Ala Gly Asn Ala Ile  Val Ser Lys 
    1145                 1150                 1155             


Ala Ala  Lys Ile Gly Ser Thr  Thr Ala Asn Gly Ile  Asn Ala Phe 
    1160                 1165                 1170             


Trp Lys  Glu Tyr Cys Asn Glu  Asp Ala Ser Thr Tyr  Glu Val Gly 
    1175                 1180                 1185             


Leu Ser  Leu Phe Glu Asn Pro  Leu Glu Glu Lys Glu  Leu Ile Glu 
    1190                 1195                 1200             


Phe Arg  Asn Tyr Ile Asp His  Phe Lys Tyr Tyr Ser  Arg Arg Asp 
    1205                 1210                 1215             


Arg Ser  Ile Leu Asn Leu Tyr  Ser Gln Val Phe Ala  Asn Tyr Phe 
    1220                 1225                 1230             


Arg His  Asp Arg Lys Leu Lys  Lys Ser Val Thr Phe  Ile Leu Lys 
    1235                 1240                 1245             


Asn Ile  Leu Ala Arg His Phe  Ile Ile Ala Arg Thr  Val Leu Ala 
    1250                 1255                 1260             


Glu Val  Glu Val Glu Lys Lys  Asp Gly Arg Lys Asp  Lys Lys Asn 
    1265                 1270                 1275             


Pro Ile  Ile Arg Lys Tyr Ser  Gln Thr Glu Ile Arg  Ile Pro Thr 
    1280                 1285                 1290             


Glu Asn  Gly Leu Gln Ser Asp  Asp Thr Leu His Lys  Tyr Thr Lys 
    1295                 1300                 1305             


Glu Asp  Val Asp Asn Glu Tyr  Lys Lys Lys Met Asn  Asn Ser Lys 
    1310                 1315                 1320             


Gly Glu  Lys Gly Lys Ile Pro  Pro Lys Glu Gly Gly  Lys Tyr Ser 
    1325                 1330                 1335             


Ile Pro  Met Tyr Asp Glu Lys  Phe Ile Gln Arg Leu  Tyr Cys Ile 
    1340                 1345                 1350             


Leu Asn  Tyr Ala Lys 
    1355             


<210>  595
<211>  1352
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  595

Met Lys Ile Ile Arg Pro Lys Gly Lys Ser Phe Thr Thr Leu Thr Gln 
1               5                   10                  15      


Thr Asp Ala Leu Glu Arg Gly Ile Arg Arg Ala Gly Asp Lys Val Ala 
            20                  25                  30          


His Pro Val Ala Phe Ser Ala Ser Arg Asp Val Ser Ala Asn Gln Leu 
        35                  40                  45              


Pro Glu Tyr Leu Ser Ala Asp Gln Glu Leu Val Leu Arg Gln Leu Val 
    50                  55                  60                  


Ser Gly Leu Asp Lys Val Val Arg Lys Pro Arg Arg Asn Asn Leu Arg 
65                  70                  75                  80  


Asn Phe Gln Ala Asp Ala Tyr Val Asp Arg Thr Lys Leu Gly Leu Glu 
                85                  90                  95      


Leu Trp Asn Ile Phe Glu Glu Gln Cys Gly Asp Ser Leu Arg Ser Leu 
            100                 105                 110         


Asp Gly Gly Ala Asp Val Leu Ala Asn Leu Ala Arg Ile Trp Arg Trp 
        115                 120                 125             


Lys Val His Pro Tyr Ser Glu Phe Ile Val Asp Met Leu Ser Pro Arg 
    130                 135                 140                 


Ser Asp Lys Asn Ala Glu Val Ile Ala Lys Tyr Gly Asp Lys Glu Leu 
145                 150                 155                 160 


Ser Arg Ser Asp Phe Tyr Gly Arg Trp His Glu Ala Phe Trp Lys Thr 
                165                 170                 175     


Thr Ser Asn Gly Arg Ala Asp Tyr Ser Ala Thr Ala Glu Ala Ile Trp 
            180                 185                 190         


Ala His Leu Phe Gln Glu Glu Ile Lys Ile Thr Lys Glu Gln Arg Asn 
        195                 200                 205             


Arg Lys Asn Ile Thr Asp Trp Pro Ala Lys Gly Leu Ala Gln Ala Lys 
    210                 215                 220                 


Gly Arg Ser Ile Ala Leu Ser Ala His Asp Pro Ala Lys Gly Gly Thr 
225                 230                 235                 240 


Leu Arg Leu Asp Asp Thr Val Asp Glu Ala Val Val Ala Leu Tyr Phe 
                245                 250                 255     


Ala His Asp Val Val Lys Glu Leu Arg Asp Ala Val Leu Thr Ala Ala 
            260                 265                 270         


Lys Ala Ser Ser Gly Arg Asn Ala Gln Phe Ser Gln Ser Asp Phe Gly 
        275                 280                 285             


Arg Met Leu Tyr Glu His Phe Gly Pro Ile Ile Lys Arg Pro Leu Asp 
    290                 295                 300                 


Glu Ser Leu Asn Arg Ser Leu Trp Arg Leu His Asn Ala Val Arg Gly 
305                 310                 315                 320 


Phe Tyr Gln Glu Leu Ala Arg Ser Glu Gly Tyr Ser Arg Ala Met Arg 
                325                 330                 335     


Asp Pro Val Arg Glu Leu Gly Lys Leu Glu Glu Leu Leu Pro Arg Asp 
            340                 345                 350         


His Gln His Leu Leu Gln Phe Leu Gly Ala Lys Asp Arg Asn Ala Gln 
        355                 360                 365             


Ile Ser Ala Leu Thr Arg Leu Gly Lys Leu Ile Ala His Ala Ser Asp 
    370                 375                 380                 


Leu Pro Ala Gly Thr Gln Asp Val Asn Ala Ala Phe Ala Glu Arg Phe 
385                 390                 395                 400 


His Phe Phe Gln Thr Ser Asp Gly Gln Ser Glu Ile Lys Arg Asn Glu 
                405                 410                 415     


Ala Phe Val Arg Val Trp Arg Thr Ser Val Gly Leu Ser Leu Arg Thr 
            420                 425                 430         


Leu His Ala Leu Thr Pro Phe Ala Leu Ile Asp Gly Arg Thr Asp Asp 
        435                 440                 445             


Leu Thr Leu Pro Glu Tyr Ala Thr Arg Ala Thr Ala Lys Tyr Asp Thr 
    450                 455                 460                 


Arg Ser Tyr Gln Arg Gly Ile Glu Leu Ile Phe Gly Ala Lys Thr Thr 
465                 470                 475                 480 


Ile Ala Leu Asp Gly Gln Ser Arg Ser Asn Met Leu Leu Val Pro His 
                485                 490                 495     


Thr Gly Gly Arg Arg Asp Thr Asp Pro Asn Thr Glu Ile Leu Trp Ala 
            500                 505                 510         


Ile Ile Arg Leu Ala Ala Glu Ile Arg Asn Arg Ala Tyr His Phe Asn 
        515                 520                 525             


Thr Lys Glu Arg Leu Leu Ser Leu Ile Glu Thr Cys Pro Val Lys Ile 
    530                 535                 540                 


Thr Asn Gln Pro Ala His Phe Gly Gly Arg Lys Pro Asn Ile Ile Asp 
545                 550                 555                 560 


Arg Val Ala Gly Glu Ala Phe Thr Arg Leu Leu Glu Phe Asp Leu Ala 
                565                 570                 575     


Leu Gln Glu Gln Val Ile Leu Asp Glu Phe Arg Arg Leu Asp Val Ser 
            580                 585                 590         


Ala Tyr Val Lys Pro Ser Asp Leu Asp Glu Leu Tyr Ala Glu Phe Ser 
        595                 600                 605             


Arg Val Pro Asp Thr Ile Gln His Thr Gln Pro Lys Phe Ile Ser Val 
    610                 615                 620                 


Leu Arg Arg Ala His Ala Ile Cys Gln Glu Asp Asp Gly Lys Pro Pro 
625                 630                 635                 640 


Ala Trp Ala Ala Pro Phe Lys Thr Leu Asp Leu Thr Gly Leu Ser Lys 
                645                 650                 655     


Val Lys Glu Gly Ala Asn His Phe Arg Leu Gly Val Leu Arg Gln Leu 
            660                 665                 670         


Tyr Lys Ser Gly Phe Ala Ala Trp Leu Ser Gln Gln Ser Asp Asn Ala 
        675                 680                 685             


Ala Leu Val Arg Ser Ala Ile Ala Glu Val Thr Ala Phe Lys Thr Gln 
    690                 695                 700                 


Arg Phe Glu Asp Tyr Tyr Gly Pro Lys Ser Asp His Arg Arg Val Tyr 
705                 710                 715                 720 


Ala Met Ala Glu Pro Ile Ala Gln Ser Leu Ala Leu Glu Thr Ala Thr 
                725                 730                 735     


Ser Leu Glu Glu Leu Phe Arg Arg Leu Gln Ser Glu Ala Met Ser Glu 
            740                 745                 750         


Asp Ser Ile Arg Gln Thr Tyr Arg Ala Ser Ala Val Lys Gln Arg Glu 
        755                 760                 765             


Arg Met Gly Gly Val Gly Glu Phe Arg Leu Asp Leu Phe Ala Arg Leu 
    770                 775                 780                 


Phe Ala Leu Tyr Leu Glu Gln Thr Asn Leu Asn His Ile Trp Gly Ile 
785                 790                 795                 800 


Thr Gly Pro Leu Pro Pro Glu Glu Arg Ala Pro Ala Glu Arg Leu Ala 
                805                 810                 815     


Thr Phe Ala Ala Pro Ala Lys Leu Leu Asp Arg Ile Glu Pro Trp His 
            820                 825                 830         


Ser Gln Phe Tyr Val Trp Leu Tyr Leu Ile Pro Ile Asp Glu Val Ala 
        835                 840                 845             


Leu Leu Arg His Gln Leu Arg Lys Thr Val Ala Leu Glu Ala Lys Ser 
    850                 855                 860                 


Gly Ile Gly Ser Gln Asp Ile Leu Ser Gln Val Asp Leu Leu Met Gly 
865                 870                 875                 880 


Leu Tyr Leu Ser Val Tyr Asp Ala Gly Phe Asp Gly Arg Glu His Val 
                885                 890                 895     


Gly Gly Leu Asn Ala Gly Lys Leu Phe Tyr Glu Ser Pro Gln Asp Phe 
            900                 905                 910         


Glu Lys Val Tyr Ser Asp Asp Gln Ser His His Glu Ile Ser Met Pro 
        915                 920                 925             


Gly Thr Arg Arg Gly Leu Arg Gln Ile Leu Arg Met Asp His Phe Arg 
    930                 935                 940                 


Ala Leu Glu Gly Ile Phe Glu Lys His Gln Val Thr Thr Asp Glu Val 
945                 950                 955                 960 


Lys Ala Phe Gln Gln Leu Lys Leu Thr Glu Val Gln Glu Ile Leu Glu 
                965                 970                 975     


Ser Lys Ile Arg Leu Gln Lys Ser Ile Ile Ser Met Ser Lys Gln Ala 
            980                 985                 990         


Lys Leu Asp Thr Glu Ala Leu Arg  Ser Glu Cys Gln Lys  Tyr Gln Val 
        995                 1000                 1005             


Ser Ala  Thr Lys Leu Ala Ile  Tyr Asn Phe Gln Val  Lys Ala Ala 
    1010                 1015                 1020             


Arg Leu  Ser Glu His Ala Arg  Leu His Gln Leu Met  Ile Arg Val 
    1025                 1030                 1035             


Leu Gly  Arg Leu Ala Asp Phe  Ser Met Met Trp Glu  Arg Asp Arg 
    1040                 1045                 1050             


Gln Tyr  Leu Phe Leu Gly Leu  Leu Tyr Arg Arg Ile  Gly Ala Glu 
    1055                 1060                 1065             


Asn Phe  Ile Leu His Arg Met  Ala Asp Glu Ile Gly  Ile Ala Leu 
    1070                 1075                 1080             


Pro Ala  Asp Ala Gly Leu Gly  Leu Val Ala Asp Ala  Gly Ala Ala 
    1085                 1090                 1095             


Thr Arg  Arg Ser Gly Ala Ile  Ser Asp Met His Val  Gln Ala Gly 
    1100                 1105                 1110             


Phe Leu  Pro Leu Trp Asp Pro  Asp Phe Gly Phe Val  Arg Glu Gly 
    1115                 1120                 1125             


Asp Gly  Ala Glu Leu Thr Leu  Leu Ala Val Gln Asp  Arg Glu Leu 
    1130                 1135                 1140             


Phe Met  Arg Tyr Phe Gly Lys  Leu Pro Glu Glu Asn  Pro Arg Asp 
    1145                 1150                 1155             


Val Arg  Arg Arg Glu Ala Asn  Glu Ala Glu Gly Phe  Ala Arg Pro 
    1160                 1165                 1170             


Ser Thr  Lys Asn Trp Asn Gly  Ser Phe Arg Leu Pro  Lys Arg Arg 
    1175                 1180                 1185             


Ile Arg  Asn Asp Phe Ala His  Phe Asn Val Ile Ser  Gly Lys Arg 
    1190                 1195                 1200             


Arg Pro  Asn Leu Thr Tyr Leu  Met Asn Ala Ile Arg  Ser Leu Met 
    1205                 1210                 1215             


Ser His  Asp Arg Lys Met Lys  Asn Ala Val Ser Lys  Ala Val Ala 
    1220                 1225                 1230             


Glu Ile  Val Ala Glu Glu Gly  Leu Glu Ile Arg Trp  Gln Val Arg 
    1235                 1240                 1245             


Gly Asp  Arg Leu Val Asp Pro  Thr Val Ile Pro Met  Leu Glu Ser 
    1250                 1255                 1260             


His Leu  Thr Met Val Arg Pro  Lys Asp Gly Phe Asp  Pro Arg Phe 
    1265                 1270                 1275             


His Leu  Pro Gln Ala Ser Val  Arg Phe Thr Ser Met  Val Lys Ala 
    1280                 1285                 1290             


Leu Phe  Glu Phe Asp Gln Gly  Gly Tyr Arg Lys Thr  Ile Pro Trp 
    1295                 1300                 1305             


Lys Glu  Gly Lys Lys Ala Ser  Arg Gly Gln Leu Gly  Tyr Pro Lys 
    1310                 1315                 1320             


Glu Phe  Ile Ala Arg Ile Glu  Gln Asp Glu Thr Ile  His Val Pro 
    1325                 1330                 1335             


Arg Glu  Val Leu Ala Gln Cys  Tyr Lys Gly Leu Glu  Gln Lys 
    1340                 1345                 1350         


<210>  596
<211>  1051
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  596

Met Lys Ile Thr Lys Met Arg Val Asp Gly Arg Thr Ile Val Met Glu 
1               5                   10                  15      


Arg Thr Ser Lys Glu Gly Gln Leu Val Tyr Glu Gly Ile Asp Gly Asn 
            20                  25                  30          


Lys Thr Thr Glu Ile Ile Phe Asp Lys Lys Lys Glu Ser Phe Tyr Lys 
        35                  40                  45              


Ser Ile Leu Asn Lys Thr Val Arg Lys Pro Asp Glu Lys Glu Lys Asn 
    50                  55                  60                  


Arg Arg Lys Gln Ala Ile Asn Lys Ala Ile Asn Lys Glu Ile Thr Glu 
65                  70                  75                  80  


Leu Met Leu Ala Leu Leu His Gln Glu Val Pro Ser Gln Lys Leu His 
                85                  90                  95      


Asn Leu Lys Ser Leu Asn Thr Glu Ser Leu Thr Lys Leu Phe Lys Pro 
            100                 105                 110         


Lys Phe Gln Asn Met Ile Ser Tyr Pro Pro Ser Lys Gly Ala Glu His 
        115                 120                 125             


Val Gln Phe Cys Leu Thr Asp Ile Ala Val Pro Ala Ile Arg Asp Leu 
    130                 135                 140                 


Asp Glu Ile Lys Pro Asp Trp Gly Ile Phe Phe Glu Lys Leu Lys Pro 
145                 150                 155                 160 


Tyr Thr Asp Trp Ala Glu Ser Tyr Ile His Tyr Lys Gln Thr Thr Ile 
                165                 170                 175     


Gln Lys Ser Ile Glu Gln Asn Lys Ile Gln Ser Pro Asp Ser Pro Arg 
            180                 185                 190         


Lys Leu Val Leu Gln Lys Tyr Val Thr Ala Phe Leu Asn Gly Glu Pro 
        195                 200                 205             


Leu Gly Leu Asp Leu Val Ala Lys Lys Tyr Lys Leu Ala Asp Leu Ala 
    210                 215                 220                 


Glu Ser Phe Lys Val Val Asp Leu Asn Glu Asp Lys Ser Ala Asn Tyr 
225                 230                 235                 240 


Lys Ile Lys Ala Cys Leu Gln Gln His Gln Arg Asn Ile Leu Asp Glu 
                245                 250                 255     


Leu Lys Glu Asp Pro Glu Leu Asn Gln Tyr Gly Ile Glu Val Lys Lys 
            260                 265                 270         


Tyr Ile Gln Arg Tyr Phe Pro Ile Lys Arg Ala Pro Asn Arg Ser Lys 
        275                 280                 285             


His Ala Arg Ala Asp Phe Leu Lys Lys Glu Leu Ile Glu Ser Thr Val 
    290                 295                 300                 


Glu Gln Gln Phe Lys Asn Ala Val Tyr His Tyr Val Leu Glu Gln Gly 
305                 310                 315                 320 


Lys Met Glu Ala Tyr Glu Leu Thr Asp Pro Lys Thr Lys Asp Leu Gln 
                325                 330                 335     


Asp Ile Arg Ser Gly Glu Ala Phe Ser Phe Lys Phe Ile Asn Ala Cys 
            340                 345                 350         


Ala Phe Ala Ser Asn Asn Leu Lys Met Ile Leu Asn Pro Glu Cys Glu 
        355                 360                 365             


Lys Asp Ile Leu Gly Lys Gly Asp Phe Lys Lys Asn Leu Pro Asn Ser 
    370                 375                 380                 


Thr Thr Gln Ser Asp Val Val Lys Lys Met Ile Pro Phe Phe Ser Asp 
385                 390                 395                 400 


Glu Ile Gln Asn Val Asn Phe Asp Glu Ala Ile Trp Ala Ile Arg Gly 
                405                 410                 415     


Ser Ile Gln Gln Ile Arg Asn Glu Val Tyr His Cys Lys Lys His Ser 
            420                 425                 430         


Trp Lys Ser Ile Leu Lys Ile Lys Gly Phe Glu Phe Glu Pro Asn Asn 
        435                 440                 445             


Met Lys Tyr Thr Asp Ser Asp Met Gln Lys Leu Met Asp Lys Asp Ile 
    450                 455                 460                 


Ala Lys Ile Pro Asp Phe Ile Glu Glu Lys Leu Lys Ser Ser Gly Ile 
465                 470                 475                 480 


Ile Arg Phe Tyr Ser His Asp Lys Leu Gln Ser Ile Trp Glu Met Lys 
                485                 490                 495     


Gln Gly Phe Ser Leu Leu Thr Thr Asn Ala Pro Phe Val Pro Ser Phe 
            500                 505                 510         


Lys Arg Val Tyr Ala Lys Gly His Asp Tyr Gln Thr Ser Lys Asn Arg 
        515                 520                 525             


Tyr Tyr Asp Leu Gly Leu Thr Thr Phe Asp Ile Leu Glu Tyr Gly Glu 
    530                 535                 540                 


Glu Asp Phe Arg Ala Arg Tyr Phe Leu Thr Lys Leu Val Tyr Tyr Gln 
545                 550                 555                 560 


Gln Phe Met Pro Trp Phe Thr Ala Asp Asn Asn Ala Phe Arg Asp Ala 
                565                 570                 575     


Ala Asn Phe Val Leu Arg Leu Asn Lys Asn Arg Gln Gln Asp Ala Lys 
            580                 585                 590         


Ala Phe Ile Asn Ile Arg Glu Val Glu Glu Gly Glu Met Pro Arg Asp 
        595                 600                 605             


Tyr Met Gly Tyr Val Gln Gly Gln Ile Ala Ile His Glu Asp Ser Thr 
    610                 615                 620                 


Glu Asp Thr Pro Asn His Phe Glu Lys Phe Ile Ser Gln Val Phe Ile 
625                 630                 635                 640 


Lys Gly Phe Asp Ser His Met Arg Ser Ala Asp Leu Lys Phe Ile Lys 
                645                 650                 655     


Asn Pro Arg Asn Gln Gly Leu Glu Gln Ser Glu Ile Glu Glu Met Ser 
            660                 665                 670         


Phe Asp Ile Lys Val Glu Pro Ser Phe Leu Lys Asn Lys Asp Asp Tyr 
        675                 680                 685             


Ile Ala Phe Trp Thr Phe Cys Lys Met Leu Asp Ala Arg His Leu Ser 
    690                 695                 700                 


Glu Leu Arg Asn Glu Met Ile Lys Tyr Asp Gly His Leu Thr Gly Glu 
705                 710                 715                 720 


Gln Glu Ile Ile Gly Leu Ala Leu Leu Gly Val Asp Ser Arg Glu Asn 
                725                 730                 735     


Asp Trp Lys Gln Phe Phe Ser Ser Glu Arg Glu Tyr Glu Lys Ile Met 
            740                 745                 750         


Lys Gly Tyr Val Gly Glu Glu Leu Tyr Gln Arg Glu Pro Tyr Arg Gln 
        755                 760                 765             


Ser Asp Gly Lys Thr Pro Ile Leu Phe Arg Gly Val Glu Gln Ala Arg 
    770                 775                 780                 


Lys Tyr Gly Thr Glu Thr Val Ile Gln Arg Leu Phe Asp Ala Ser Pro 
785                 790                 795                 800 


Glu Phe Lys Val Ser Lys Cys Asn Ile Thr Glu Trp Glu Arg Gln Lys 
                805                 810                 815     


Glu Thr Ile Glu Glu Thr Ile Glu Arg Arg Lys Glu Leu His Asn Glu 
            820                 825                 830         


Trp Glu Lys Asn Pro Lys Lys Pro Gln Asn Asn Ala Phe Phe Lys Glu 
        835                 840                 845             


Tyr Lys Glu Cys Cys Asp Ala Ile Asp Ala Tyr Asn Trp His Lys Asn 
    850                 855                 860                 


Lys Thr Thr Leu Val Tyr Val Asn Glu Leu His His Leu Leu Ile Glu 
865                 870                 875                 880 


Ile Leu Gly Arg Tyr Val Gly Tyr Val Ala Ile Ala Asp Arg Asp Phe 
                885                 890                 895     


Gln Cys Met Ala Asn Gln Tyr Phe Lys His Ser Gly Ile Thr Glu Arg 
            900                 905                 910         


Val Glu Tyr Trp Gly Asp Asn Arg Leu Lys Ser Ile Lys Lys Leu Asp 
        915                 920                 925             


Thr Phe Leu Lys Lys Glu Gly Leu Phe Val Ser Glu Lys Asn Ala Arg 
    930                 935                 940                 


Asn His Ile Ala His Leu Asn Tyr Leu Ser Leu Lys Ser Glu Cys Thr 
945                 950                 955                 960 


Leu Leu Tyr Leu Ser Glu Arg Leu Arg Glu Ile Phe Lys Tyr Asp Arg 
                965                 970                 975     


Lys Leu Lys Asn Ala Val Ser Lys Ser Leu Ile Asp Ile Leu Asp Arg 
            980                 985                 990         


His Gly Met Ser Val Val Phe Ala  Asn Leu Lys Glu Asn  Lys His Arg 
        995                 1000                 1005             


Leu Val  Ile Lys Ser Leu Glu  Pro Lys Lys Leu Arg  His Leu Gly 
    1010                 1015                 1020             


Glu Lys  Lys Ile Asp Asn Gly  Tyr Ile Glu Thr Asn  Gln Val Ser 
    1025                 1030                 1035             


Glu Glu  Tyr Cys Gly Ile Val  Lys Arg Leu Leu Glu  Ile 
    1040                 1045                 1050     


<210>  597
<211>  1246
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  597

Met Tyr Met Lys Ile Thr Lys Ile Asp Gly Val Ser His Tyr Lys Glu 
1               5                   10                  15      


Lys Glu Lys Gly Val Leu Lys Gly Lys Asp Ile Leu Asn Gly Lys Ile 
            20                  25                  30          


Glu Lys Ile Val Lys Lys Arg Tyr Asp Ala Thr Ile Glu Ser Lys Ile 
        35                  40                  45              


Tyr Lys Glu Phe Ile Lys Leu Arg Lys Asn Arg Ile Glu Gln Asn Asn 
    50                  55                  60                  


Glu Lys Ser Ile Leu Glu Leu Ile Lys Ser Asn Ile Asp Lys Asn Glu 
65                  70                  75                  80  


Lys Glu Ile Lys Thr Leu Leu Trp Lys Asn Phe Lys Ile Lys Glu Lys 
                85                  90                  95      


Asn Lys Asn Tyr Asp Glu Tyr Ile Thr Asp Glu Ile Lys Leu Asp Asn 
            100                 105                 110         


Asp Ile Lys Ile Tyr Glu Ser Val Glu Ser Leu Tyr Phe Leu Ile Lys 
        115                 120                 125             


Glu Ile Tyr Leu Gly Gln Asn Asn Lys Lys Trp Asn Ile Ser Lys Ile 
    130                 135                 140                 


Asp Leu Glu Lys Ile Met Glu Glu Asp Ser Asp Leu Ile Met Leu Gly 
145                 150                 155                 160 


Tyr Lys Leu Lys Lys Asn Ile Lys Glu Asp Asp Tyr Pro Tyr Leu Tyr 
                165                 170                 175     


Arg Asp Lys Asn Gly Gln Glu Ser Thr Ser Val Tyr Lys Leu Leu Lys 
            180                 185                 190         


Lys Leu Ile Glu Glu Asn Lys Asp Arg Asn Gln Asp Ile Arg Lys Ser 
        195                 200                 205             


Gln Glu Tyr Glu Lys Ile Arg Lys Asn Phe Glu Glu Tyr Lys Asn Arg 
    210                 215                 220                 


Lys Ile Asn Leu Leu Val Lys Ser Ile Lys Asn Asn Lys Ile Asn Ile 
225                 230                 235                 240 


Gln Tyr Ile Asn Asn Glu Ile Lys Ser His Asp Asn Pro Arg Glu Glu 
                245                 250                 255     


Asn Ile Ile Lys Phe Phe Arg Lys Met Ile Glu Glu Lys Asn Lys Pro 
            260                 265                 270         


Ile Leu Lys Asp Lys Leu Lys Leu Phe Arg Leu Glu Val Phe Phe Asn 
        275                 280                 285             


Glu Glu Phe Leu Glu Glu Ile Lys Lys Leu Leu Asp Ser Asp Asp Ser 
    290                 295                 300                 


Asp Lys Ser Gln Asn Lys Lys Ile Ser Glu Leu Arg Gly Lys Ile Phe 
305                 310                 315                 320 


Asn Arg Ile Arg Glu Glu Ile Lys Asn Asn Lys Asn Arg Asp Glu Leu 
                325                 330                 335     


Glu Asn Ile Tyr Phe Leu Glu Leu Lys Lys Tyr Ile Glu Asn Asn Leu 
            340                 345                 350         


Ser His Lys Lys Glu Lys Asn Lys Asn Ser Asn Asn Thr Gly Glu Glu 
        355                 360                 365             


Lys Ser Lys Lys Leu Tyr Leu Lys Phe Leu Lys Lys Val Leu Phe Ile 
    370                 375                 380                 


Asp Asp Asn Asn Arg Ile Ser Ile Glu Lys Leu Lys Ser Arg Ile Asp 
385                 390                 395                 400 


Asp Asn Phe Lys Asn Leu Leu Ile Gln His Val Ile Glu Tyr Gly Lys 
                405                 410                 415     


Ile Lys Tyr Tyr Val Glu Asn Asp Asp Tyr Ile Arg Asn Ile Val Lys 
            420                 425                 430         


Asn Gly Glu Leu Lys Leu Glu Thr Lys Asp Leu Glu Tyr Ile Lys Thr 
        435                 440                 445             


Lys Glu Thr Leu Ile Arg Lys Met Ala Val Leu Val Ser Phe Ala Ala 
    450                 455                 460                 


Asn Ser Tyr Tyr Asn Leu Phe Gly Ser Ala Ser Glu Asp Ile Leu Gly 
465                 470                 475                 480 


Thr Glu Val Val Lys Asn Arg Arg Thr Asn Val Ile Lys Val Lys Ser 
                485                 490                 495     


Tyr Ile Phe Lys Glu Lys Met Leu Asn Tyr Phe Phe Asp Ser Glu Asp 
            500                 505                 510         


Phe Asp Val Asn Lys Thr Ile Glu Val Leu Glu Ser Ile Ser Tyr Ser 
        515                 520                 525             


Ile Tyr Asn Ile Arg Asn Gly Val Gly His Phe Asn Lys Leu Val Leu 
    530                 535                 540                 


Gly Lys Tyr Lys Lys Lys Asp Ile Ser Thr Asn Lys Arg Val Glu Glu 
545                 550                 555                 560 


Asp Leu Asn Asn Asn Glu Glu Ile Lys Gly Tyr Phe Ile Lys Lys Arg 
                565                 570                 575     


Gly Glu Ile Glu Lys Lys Ile Lys Glu Arg Phe Leu Ser Asn Asn Leu 
            580                 585                 590         


Gln Tyr Tyr Tyr Ala Lys Glu Arg Ile Glu Asn Tyr Phe Glu Val Tyr 
        595                 600                 605             


Glu Phe Glu Ile Leu Lys Glu Lys Ile Pro Phe Ala Pro Asn Phe Lys 
    610                 615                 620                 


Arg Ile Ile Lys Lys Gly Glu Asn Leu Leu Asn Asn Lys Lys Tyr Glu 
625                 630                 635                 640 


Tyr Phe Lys Asn Phe Asp Lys Asn Ser Val Glu Glu Lys Lys Glu Phe 
                645                 650                 655     


Leu Lys Thr Arg Asn Phe Leu Leu Lys Glu Leu Tyr Tyr Asn Asn Phe 
            660                 665                 670         


Tyr Lys Glu Phe Leu Ser Lys Lys Glu Glu Phe Lys Lys Ile Val Ile 
        675                 680                 685             


Glu Val Lys Glu Glu Lys Lys Asn Arg Gly Asn Asn Lys Lys Ser Gly 
    690                 695                 700                 


Val Ser Phe Gln Ser Ile Asp Asp Tyr Asp Thr Lys Ile Asn Ile Ser 
705                 710                 715                 720 


Asp Tyr Ile Ala Ser Ile His Lys Lys Glu Met Glu Arg Val Glu Lys 
                725                 730                 735     


Tyr Asn Glu Glu Lys Gln Lys Asp Thr Ala Lys Tyr Ile Arg Asp Phe 
            740                 745                 750         


Val Glu Glu Ile Phe Leu Thr Gly Phe Ile Asn Tyr Leu Glu Lys Asp 
        755                 760                 765             


Lys Arg Leu His Phe Leu Lys Glu Glu Phe Ser Ile Leu Cys Asn Asn 
    770                 775                 780                 


Asn Asn Val Val Asp Phe Asn Ile Asn Ile Asn Glu Glu Lys Ile Lys 
785                 790                 795                 800 


Glu Phe Leu Lys Glu Asn Asp Ser Lys Thr Leu Asn Leu Tyr Leu Phe 
                805                 810                 815     


Phe Asn Met Ile Asp Ser Lys Arg Ile Ser Glu Phe Arg Asn Glu Leu 
            820                 825                 830         


Ile Lys Tyr Lys Gln Phe Thr Lys Lys Arg Leu Asp Glu Glu Lys Glu 
        835                 840                 845             


Phe Leu Gly Ile Lys Ile Glu Leu Tyr Glu Thr Leu Ile Glu Phe Val 
    850                 855                 860                 


Ile Leu Thr Arg Glu Lys Leu Asp Thr Lys Lys Ser Glu Glu Thr Asp 
865                 870                 875                 880 


Ala Trp Leu Val Asp Lys Leu Tyr Val Lys Glu Lys Asn Glu Cys Asn 
                885                 890                 895     


Glu Tyr Glu Tyr Lys Glu Tyr Glu Glu Ile Leu Lys Leu Phe Val Asp 
            900                 905                 910         


Glu Lys Ile Leu Asn Ser Lys Glu Ala Pro Tyr Tyr Ala Thr Asn Asn 
        915                 920                 925             


Lys Thr Pro Ile Leu Leu Ser Asn Phe Glu Lys Thr Arg Lys Tyr Gly 
    930                 935                 940                 


Thr Gln Ser Phe Leu Ser Glu Ile Gln Ser Asn Tyr Lys Tyr Ser Lys 
945                 950                 955                 960 


Val Glu Lys Glu Asn Ile Glu Asp Tyr Asn Lys Lys Glu Glu Ile Glu 
                965                 970                 975     


Lys Lys Lys Lys Ser Asn Ile Glu Lys Leu Gln Asp Leu Lys Val Glu 
            980                 985                 990         


Leu His Lys Lys Trp Glu Gln Asn  Lys Ile Thr Glu Lys  Glu Ile Lys 
        995                 1000                 1005             


Lys Tyr  Asn Asp Thr Ile Lys  Glu Ile Arg Glu Tyr  Asn Tyr Leu 
    1010                 1015                 1020             


Lys Asn  Lys Glu Glu Leu Gln  Asn Val Tyr Leu Leu  His Glu Ile 
    1025                 1030                 1035             


Leu Ser  Asp Leu Leu Ala Arg  Asn Val Ala Phe Phe  Asn Lys Trp 
    1040                 1045                 1050             


Glu Arg  Asp Phe Lys Phe Ile  Val Ile Ala Ile Lys  Gln Phe Leu 
    1055                 1060                 1065             


Arg Glu  Asn Asp Lys Glu Lys  Val Glu Asn Phe Leu  Asn Pro Leu 
    1070                 1075                 1080             


Asp Asn  Ser Lys Gly Lys Lys  Val Tyr Phe Ser Val  Ser Lys Tyr 
    1085                 1090                 1095             


Lys Asn  Thr Val Glu Asn Ile  Asp Gly Ile His Lys  Asn Phe Met 
    1100                 1105                 1110             


Asn Leu  Ile Phe Leu Asn Asn  Lys Phe Met Asn Arg  Lys Ile Asp 
    1115                 1120                 1125             


Lys Met  Asn Cys Thr Ile Trp  Val Tyr Phe Arg Asn  Tyr Ile Ala 
    1130                 1135                 1140             


His Phe  Leu His Leu His Thr  Lys Asn Glu Lys Ile  Ser Leu Ile 
    1145                 1150                 1155             


Asn Gln  Met Asn Leu Leu Ile  Lys Leu Phe Ser Tyr  Asp Lys Lys 
    1160                 1165                 1170             


Val Gln  Asn His Ile Leu Lys  Ser Thr Lys Thr Leu  Leu Glu Lys 
    1175                 1180                 1185             


Tyr Asn  Ile Gln Ile Asn Phe  Glu Ile Ser Asn Asp  Lys Asn Glu 
    1190                 1195                 1200             


Val Phe  Lys Tyr Lys Ile Lys  Asn Arg Leu Tyr Ser  Lys Lys Gly 
    1205                 1210                 1215             


Lys Met  Leu Gly Lys Asn Asn  Lys Phe Glu Ile Leu  Glu Asn Glu 
    1220                 1225                 1230             


Phe Leu  Glu Asn Val Lys Ala  Met Leu Glu Tyr Ser  Glu 
    1235                 1240                 1245     


<210>  598
<211>  1373
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  598

Met Ala Lys His Leu Arg Pro Ile Gly Glu Ser Tyr Thr Asp Phe Leu 
1               5                   10                  15      


Asp Glu Thr Glu Phe Val Arg Leu Gly Arg Gly Leu His Arg Gly His 
            20                  25                  30          


His Gly Val Gln Ile Pro Pro Thr Glu Leu Pro Ser Tyr Leu Ala Glu 
        35                  40                  45              


Tyr Arg Lys Ala Leu Met Arg Gln Val Val Ala Val Leu Asp Lys Val 
    50                  55                  60                  


Val Gly Lys Arg Arg Arg Leu Ser Gly Met His Pro Glu Ala Tyr Arg 
65                  70                  75                  80  


Asp Arg Val His Leu Ala Glu Ala Leu Trp Val Arg Leu Val Ala Arg 
                85                  90                  95      


Val Lys Glu Ile Gly Thr Pro Pro Asp Pro Ser Glu Leu Leu Asp Leu 
            100                 105                 110         


Arg Arg Met Trp Asn Ala Lys Ala His Pro Tyr Ala Glu Tyr Asp Val 
        115                 120                 125             


Val Pro Arg Ala Pro Leu Asn Asp Gly Asn Gly Gln Lys Ile Leu Glu 
    130                 135                 140                 


Cys Arg Glu Val Asp Asp Pro Lys Ile Glu Arg Ser Asp Phe Glu Gly 
145                 150                 155                 160 


Arg Trp His Gly Arg Phe Trp Gln Ser Glu Pro Gly Pro Val Asp Tyr 
                165                 170                 175     


Asn Ala Ile Ala Asp Arg Ile Phe Ala His Leu Phe Asp Gln Glu Ala 
            180                 185                 190         


Val Ile Gly Gly Gly Pro Arg Arg Glu Gly Asn Val Thr Val Pro Asp 
        195                 200                 205             


Glu Asp Ile Asn Gly Gln Pro Gly Pro Ala Thr Gly Lys Gly Leu Ile 
    210                 215                 220                 


Ile Ala Arg Gly Gln Ser Ile Val Lys Ser Ala Ser Asp Pro Arg Arg 
225                 230                 235                 240 


Ser Ser Lys Lys Val Gln Arg Thr Trp Asp Lys Ala Val Glu Arg Arg 
                245                 250                 255     


Tyr Phe Gly Asp Asp Gly Lys Gly Gly Ser Asp Ile Ala Lys Ala Ile 
            260                 265                 270         


Tyr Glu Glu Leu Gly Asp Pro Ala Thr Leu Ala Asp Pro Ile Tyr Ala 
        275                 280                 285             


Ser Trp Phe Gly Ser Arg Leu Tyr Asp His Phe Gly Ser Phe Lys Asn 
    290                 295                 300                 


Ser Leu Pro Leu Glu Leu Lys Asp Pro Phe Lys Glu Gln Ile Trp Ala 
305                 310                 315                 320 


Leu His Asn Ser Val Arg Gln Phe Tyr Gln Arg Met Ala Lys Ser Asp 
                325                 330                 335     


Arg Phe Arg Leu Ala Leu Gln Asn Ala Arg Ser Glu Val Pro Asp Arg 
            340                 345                 350         


Ser Glu Leu Leu Ala Leu Leu Pro Lys Asp His Asp His Leu Leu Leu 
        355                 360                 365             


Val Leu Gly Gly Lys Lys Lys Asn Ala Glu Met Ser Glu Leu Ile Arg 
    370                 375                 380                 


Leu Gly Lys Leu Phe Val His Ala Ser Asp Val Leu His Asp Phe Asp 
385                 390                 395                 400 


Ala Asn Asp Ala Ala Ala Leu Asp Ala Phe Lys Arg Arg Met Ser Phe 
                405                 410                 415     


Leu Ala Thr Ser Ile Gly Gln Ser Glu Ile Lys Gln Thr Glu Thr Phe 
            420                 425                 430         


Ala Arg Thr Trp Arg Gly Ala Val Gly Leu Thr Leu Arg Thr Val Lys 
        435                 440                 445             


Gly Leu Ala Asp Pro Arg Gly Ile Ile Gly Thr Pro Asp Asn Arg Asp 
    450                 455                 460                 


Leu Gly Thr Ala Gly Pro Met Lys Asp Ala Phe Asn Lys Phe Asp Gln 
465                 470                 475                 480 


Pro His Phe Gln Gln His Met Thr Ile Ile Phe Gly Asn Lys Glu Leu 
                485                 490                 495     


Gln Ala Glu Gly Asn Pro Thr Arg Ser Ser Val Phe Thr Ala Asn Gly 
            500                 505                 510         


Asp Lys Asp His Gln Ala Glu Leu Leu Trp Gly Phe Leu Cys Val Val 
        515                 520                 525             


Arg Ser Val Arg Asn Arg Thr Asn His Tyr Asn Val Arg Arg Ala Leu 
    530                 535                 540                 


Leu Arg Leu Leu Asp Glu Gly Ile Val Ser Pro Met Pro Ser Asp Pro 
545                 550                 555                 560 


Lys Lys Glu Arg Val Glu Asn Arg Asn Leu Cys Thr Val Ser Pro Thr 
                565                 570                 575     


Ala Leu Glu Ala Phe Arg Arg Leu Leu Asn Phe Asp Leu Ala Ile Gln 
            580                 585                 590         


Lys Glu Ala Val Arg Thr Ala Leu Glu Gln Ala Lys Ala Ser Glu Phe 
        595                 600                 605             


Val Glu Glu Gly Lys Leu Arg Gly Leu Val Ser Glu Leu Ala Gly Thr 
    610                 615                 620                 


Glu Asp Met Pro Ala Leu His Ile Pro Arg Phe Ser Ala Val Met Asp 
625                 630                 635                 640 


Lys Val Arg Arg Leu Ala Asp Asn Arg Asp Val Gly Leu Asp Pro Ile 
                645                 650                 655     


Leu Ser Thr Leu Gln Arg Ser Leu Pro Pro Thr Asp Lys Gln Ala Glu 
            660                 665                 670         


Ser Asp Ala Ala Arg Cys Arg Tyr Arg Leu Leu Leu Glu Leu Tyr Lys 
        675                 680                 685             


Ser Gly Phe Arg Ser Trp Phe Ser Gly Ile Gln Ser Asn Glu Glu Asn 
    690                 695                 700                 


Asn Arg Glu Ile Cys His Trp Ala Val Lys Gln Val Gly Arg Ala Lys 
705                 710                 715                 720 


Asp Ala Arg Lys Ser Glu Tyr Asp Lys Lys Thr Lys Arg His Tyr Arg 
                725                 730                 735     


Ser Pro Asn Ser Leu Ile Asp Asp Leu Gly Leu Asp Lys Phe Asp Asp 
            740                 745                 750         


Leu Thr Asp Leu Leu Glu Ala Leu Ala Ser Gln Ser Thr Arg Glu His 
        755                 760                 765             


Asp Gln Asn Leu Lys Tyr Val Pro Asp Ala Arg Val Gln Ser Gln Met 
    770                 775                 780                 


Ser Asn Arg Ile Glu Glu Phe Arg Gln Glu Leu Phe Ala His Ile Phe 
785                 790                 795                 800 


Thr Lys Tyr Leu Asp Thr His Asp Phe Gly Trp Ile Gly Ala Ile Glu 
                805                 810                 815     


Val Arg Arg Glu Ala Cys Asp Leu Ala Asp Val Val Ser Ala Phe Glu 
            820                 825                 830         


Val Arg Asp Gln Lys Phe Asp Ala Asp Trp His Ser Gln Phe Tyr Ala 
        835                 840                 845             


Trp Leu Tyr Met Val Pro Pro Ile Glu Ala Ser Arg Leu Arg His Gln 
    850                 855                 860                 


Met Arg Lys Ser Ala Val Met Asp Asp Lys Trp Ser Thr Thr Leu Glu 
865                 870                 875                 880 


Leu Thr Ser Gly Asp Arg Lys Thr Arg Asp Asp His Ala Gln Asp Val 
                885                 890                 895     


Leu Ala Asp Met Asp Arg Leu Phe Ser Leu Tyr Thr Lys Val Gln Ala 
            900                 905                 910         


Ala Gly Phe Asn Gly Gln Glu His Glu Ser Ala Leu Gly Ser Lys Ser 
        915                 920                 925             


Leu Phe Tyr Glu Asp Gly Asn Gln Phe Asp Glu Val Tyr Ser Pro Asp 
    930                 935                 940                 


Thr Glu Thr His Asn Lys Thr Phe Pro Gly Thr Arg Arg Gly Leu Arg 
945                 950                 955                 960 


Gln Leu Val Arg Tyr Ala His Leu Pro Ala Leu Glu Gly Val Phe Lys 
                965                 970                 975     


Lys His Arg Ile Thr Lys Ala Glu Val Glu Thr Phe Val Ala Leu Tyr 
            980                 985                 990         


Asp Glu Asn Arg Arg Asp Pro Gly  Ser Val Ala His Met  Leu Arg Arg 
        995                 1000                 1005             


Glu Lys  Leu Arg Thr Glu Ile  Leu Arg Ser Ile His  Asp Gly Pro 
    1010                 1015                 1020             


Lys Pro  Lys Asp Lys Asp Phe  Trp Pro Lys Leu Glu  Ala Lys Cys 
    1025                 1030                 1035             


Leu Glu  Tyr Arg Thr Val Ala  Thr Glu Thr Ala Ile  Tyr Asn Phe 
    1040                 1045                 1050             


Gln Ala  Asn Ala Ala Arg Leu  Asn Asp His Ala Arg  Leu His Gln 
    1055                 1060                 1065             


Ile Val  Met Arg Val Val Ala  Arg Leu Thr Asp Tyr  Ala Leu Ile 
    1070                 1075                 1080             


Trp Glu  Arg Asp Arg Leu Phe  Ala Phe Val Gly Met  Leu Tyr Arg 
    1085                 1090                 1095             


Gln Thr  Gly Gly Thr Gly Ile  Asn Pro Ala Met Arg  His Ala Glu 
    1100                 1105                 1110             


Lys Thr  Asn Ala Pro Pro Arg  Ile Gly Ile Leu Val  Ser Asp Ser 
    1115                 1120                 1125             


Ala Leu  Ala Lys Lys Leu Asn  Ser Asn Ser Ala Glu  Val Phe Ile 
    1130                 1135                 1140             


Pro Tyr  Leu Asp Thr Glu Thr  Gly Phe Asp Ala Pro  Arg Phe Asp 
    1145                 1150                 1155             


Asp Leu  Cys Thr Leu Leu Ser  His Glu His Ala Lys  Glu Phe Arg 
    1160                 1165                 1170             


Phe His  Phe Leu Glu Val Gly  Glu Glu Asn Ser Lys  Asp Glu Ala 
    1175                 1180                 1185             


Arg Arg  Leu Asn Glu Glu Thr  Met Gly His Arg Lys  Arg Pro Ala 
    1190                 1195                 1200             


Phe Lys  Arg Gly Thr Arg Arg  Gln Gly Ile Arg Asn  Asp Leu Ala 
    1205                 1210                 1215             


His His  Asn Val Leu Asp Leu  Ala Gly Gly Ala Gly  Pro Asn Leu 
    1220                 1225                 1230             


Thr Tyr  Val Val Asn Ala Val  Arg Ser Leu Leu Ser  Tyr Asp Arg 
    1235                 1240                 1245             


Lys Leu  Lys Asn Ala Val Pro  Lys Ser Ile Lys Arg  Ile Leu Gly 
    1250                 1255                 1260             


Glu Glu  Gly Leu Ile Ile Glu  Trp Gln Met Asn Tyr  Asp Arg Leu 
    1265                 1270                 1275             


Lys Lys  Pro Thr Val Tyr Pro  Asn Val Glu Thr His  Leu Thr Met 
    1280                 1285                 1290             


Val Pro  Pro Arg His Met Thr  Ala Pro Val Ser Phe  Thr Leu Pro 
    1295                 1300                 1305             


Arg Ala  Ser Val Arg Leu Ala  Ser Met Val Lys Ala  Val Phe Asp 
    1310                 1315                 1320             


Phe Gly  Ser Ser Gly Tyr Gly  Glu Glu Arg Met Ile  Gly Gly Arg 
    1325                 1330                 1335             


Thr Ala  Lys Gln Ala Val Tyr  Pro Asp Asp Phe Thr  Arg Arg Phe 
    1340                 1345                 1350             


Pro Gln  Thr Pro Met Gly Leu  Lys Gln Ala Thr Arg  Leu Val Phe 
    1355                 1360                 1365             


Ala Ser  Glu Asn Ser 
    1370             


<210>  599
<211>  1287
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  599

Met Arg Ile Gly Lys Val Gln Gly Arg Thr Phe Thr Gly Phe Asp Asn 
1               5                   10                  15      


Ala Arg Gly Lys Thr Leu Arg Arg Arg Leu Leu Thr Arg Pro Asp Asn 
            20                  25                  30          


Glu Ala Arg Ser Leu Ser Glu His Leu Ala His Asp Pro Lys Ala Leu 
        35                  40                  45              


Ile Gly Gln Ala Ile Ser Arg Ile Asp Thr Ile Tyr Gln Lys Pro Lys 
    50                  55                  60                  


Thr Gly Lys Pro Thr Pro Glu Gln Phe Gly His Arg Asp Thr Leu Gly 
65                  70                  75                  80  


Trp Ala Tyr Trp Lys Leu Leu Val Ala Ser Tyr Pro Glu Val Glu Gly 
                85                  90                  95      


His Arg Asp Leu Phe Val Arg Arg Leu His Pro Tyr Gly Asp Thr Pro 
            100                 105                 110         


Pro Lys Ser His Gly Gln Lys Glu Gly Glu His Gln Lys Gly Gly Lys 
        115                 120                 125             


Pro Gln Leu Glu Gly Arg Trp His Gly Val Met Ala Gln His Gly Lys 
    130                 135                 140                 


Asn Pro Asp Gln Ile Ala Ala Arg Leu Phe Asp His Leu His Asn Ser 
145                 150                 155                 160 


Glu Leu Arg Phe Gly Gly Thr Ala Ser Gly Glu Pro Arg Thr Arg Pro 
                165                 170                 175     


Gly Lys Glu Ala Thr Pro Thr Gly Leu Ile Gly Ala Arg Ala Lys Thr 
            180                 185                 190         


Ile Glu His Ser Val Leu Pro Arg Asp Ala Lys Arg Phe Val Ala Glu 
        195                 200                 205             


Trp Arg Gly Glu Asp Gln Glu Arg Tyr Ala Gly Ala Arg Asp Ile Ala 
    210                 215                 220                 


Ala Ala Ile Ser Ala Gly Leu Asn Asp Lys Asp Gln Lys Ser Gly Ser 
225                 230                 235                 240 


Gly Arg Lys Ser Ala Val Ile Gly Lys Leu Leu Ser Asp His Leu Glu 
                245                 250                 255     


Thr Leu Thr Gly Asn Arg Lys Cys Arg Phe Asp Pro Lys Ser Thr Ala 
            260                 265                 270         


Glu Thr Leu Glu Leu Arg Asp Gly Glu Ser Val Asp Asp Arg Arg Arg 
        275                 280                 285             


Ile Leu Glu Leu His Ala Glu Val Lys Ala Thr Tyr Lys Arg Met Ala 
    290                 295                 300                 


Ala Trp Lys Pro Ala Lys Leu Pro Arg Asn Ser Asp Glu Leu Phe Arg 
305                 310                 315                 320 


Leu Val Arg Gln Gln Ala Asp Asn Arg Ile Leu Asn His Leu Val Arg 
                325                 330                 335     


Val Gly Arg Ile Ser Val Tyr Ser Glu Gln Ser Asp Ala Leu Ser Glu 
            340                 345                 350         


Ser Gln Phe Trp Thr Ser Gly Gly Gln Thr Gln Ile Lys Glu Ser Glu 
        355                 360                 365             


Val Phe Ala Arg Leu Trp Ile Gly Ala Ile Ser Arg Ala Ser Tyr Ser 
    370                 375                 380                 


Met Lys Ala Trp Leu Glu Pro Glu Gly Thr Val Phe Asn Pro Ser Ile 
385                 390                 395                 400 


Asn Asp Phe Asp Val Thr Ser Ser His Asn Thr Asn Arg Ile Leu Glu 
                405                 410                 415     


Asp Ser Gly Arg Leu Ser Asn Ala Met Ala Arg Arg Ala Ile Tyr Phe 
            420                 425                 430         


Gly Glu Thr Pro Glu Phe Asp Ala Leu Gly Glu Glu Asp Gln Arg Val 
        435                 440                 445             


Leu Val Lys Lys Cys Leu Asp Ala Leu Ser Ala Cys Arg Asn Arg Thr 
    450                 455                 460                 


Phe His His Gly Gln Arg Ala Lys Phe Leu Lys Glu Val Arg Lys Gly 
465                 470                 475                 480 


Leu Lys Glu Lys Glu Ala Asp Ser Ala Gly Pro Ala Ala Trp Glu Gly 
                485                 490                 495     


Ile Arg Glu Val Ile Gln Ala Asp Ala Arg Asn Leu Gly Ala Arg Leu 
            500                 505                 510         


Leu Gln Asp Leu Thr Gly Ala Lys Val His Ser Phe Ala Thr Asp Pro 
        515                 520                 525             


Glu Phe Arg His Leu Tyr Glu Ser Val Ala Ala Thr Leu Thr Ala Gly 
    530                 535                 540                 


Gly Glu Leu Glu Ala Ala Leu Pro Arg Leu Lys Asn Val Leu Lys Arg 
545                 550                 555                 560 


Ala Glu Gly Val Arg Cys Tyr Leu Asp Thr Pro Ser Gln Arg Arg Glu 
                565                 570                 575     


Gly Asp Glu Ser Leu Ile Ala Arg Leu Pro Val Ala Pro Val Pro Arg 
            580                 585                 590         


Glu Leu Asp Asp Ala Ala Thr Lys Ala Arg His Ser Ala Leu Leu Arg 
        595                 600                 605             


Leu Tyr Asp Gly Pro Phe Arg Pro Trp Ala Thr Glu Leu Arg Gly Glu 
    610                 615                 620                 


Arg Leu Ser Asp Tyr Ala Ala Arg Ala Lys Arg Leu Ala Thr Arg Leu 
625                 630                 635                 640 


Ala Lys Ser Thr Asn Thr Ala Ser Pro Tyr Pro Asp Ser Val Glu Gly 
                645                 650                 655     


Arg Ser Val Arg Leu Arg Asp Pro Ile Thr Ala Asp Thr Ala Pro Glu 
            660                 665                 670         


Thr Leu Lys Thr Tyr Leu Ser Ala Leu Thr Ala Glu Thr Ala Thr Glu 
        675                 680                 685             


Phe Arg Val Gln Lys Gly Tyr Glu Ser Asp Gly Glu Lys Ala Lys Glu 
    690                 695                 700                 


Gln Ala Glu Phe Ile Glu Asp Phe Arg Arg Asp Met Ile Ala Leu Ala 
705                 710                 715                 720 


Phe Gln Asp Phe Ile Arg Asp His Gly Phe Ala Trp Leu Leu Asp Ile 
                725                 730                 735     


Ala Ser Lys Ala Glu Pro Ser Asn Asp Ala Pro Asn Leu Pro Asp Pro 
            740                 745                 750         


Val Asp Thr Gly Lys Asp Thr Val Phe Glu Asp Trp Gln Ala Leu Leu 
        755                 760                 765             


Tyr Leu Phe Leu His Phe Val Pro Ala Asp Asp Val Ser Gln Leu Leu 
    770                 775                 780                 


His Gln Leu Arg Lys Trp Asp Ala Leu Gln Asp Lys Tyr Glu Leu Ala 
785                 790                 795                 800 


Glu Pro Gly Glu Thr Leu Gly Gln Thr Lys Ala Asp Thr Arg Lys Ile 
                805                 810                 815     


Val Gly Gln Phe Arg Asp Cys Leu Thr Leu Phe Leu Lys Thr Gly Asp 
            820                 825                 830         


Ala Arg Phe Asp Gly Glu Gly Val Glu Leu Pro Leu Ser Asp Phe Gln 
        835                 840                 845             


Glu Leu Phe Glu Ser Pro Ala Thr Phe Lys Glu Leu Phe Leu Ala Glu 
    850                 855                 860                 


Pro Ala Glu Asn Asp Ala Ser Glu Thr Asp Asp Gln Asp Ala Pro Gly 
865                 870                 875                 880 


Glu Lys His Arg Val Thr Arg Thr Arg Arg Gly Leu Arg Gln Ile Leu 
                885                 890                 895     


Arg Tyr Asn His Met Pro Val Leu Arg Asp Leu Phe Leu Ala His Lys 
            900                 905                 910         


Val Thr Asp Ala Glu Val Asp Gly Leu Gln Ala Leu Glu Val Asp Asp 
        915                 920                 925             


Pro Gln Thr Gly Glu Ser Gln Ile Gly Ala Ala Gln Arg Ile Arg Thr 
    930                 935                 940                 


Glu Ile His His His Thr Ser Asn Asp Lys Gln Ile Ser Glu Ala Lys 
945                 950                 955                 960 


Val Glu Glu Tyr Arg Arg Ala Leu Ser Thr Ile Glu Arg His Arg Phe 
                965                 970                 975     


Leu Val Gly Arg Val Tyr Leu Gly Asp His Ile Arg Val His Lys Leu 
            980                 985                 990         


Met Met Asp Val Met Gly Arg Leu  Val Asp Phe Ala Gly  Ala Trp Glu 
        995                 1000                 1005             


Arg Glu  Ala Ala Asp Gly Asp  Arg Lys Gly Phe Ile  Ser Arg Ala 
    1010                 1015                 1020             


Ile Ala  Leu Pro Glu Val Ala  Glu Gly Tyr Ala Ala  Asp Arg Leu 
    1025                 1030                 1035             


Lys Thr  Val Ala Arg Arg Val  Leu Asp Asp Gly Glu  Ala Arg Arg 
    1040                 1045                 1050             


Ile Arg  Asn Asp Leu Gly His  Phe Asn Asp Leu Ala  Pro Thr Ser 
    1055                 1060                 1065             


Gly Pro  Ala Asn Leu Thr Phe  Val Val Asn Arg Ala  Arg Arg Met 
    1070                 1075                 1080             


Met Arg  His Asp Arg Lys Arg  Lys Asn Ala Val Thr  Lys Ser Val 
    1085                 1090                 1095             


Ile Glu  Ile Leu Asn Arg Gln  Gly Leu Gly Ile Glu  Trp Thr Met 
    1100                 1105                 1110             


Arg Asn  His Glu Leu Cys Glu  Ala Lys Leu Trp Gln  Asn Pro Val 
    1115                 1120                 1125             


Lys His  Leu Gly Phe Ala Thr  Leu Glu Gly Arg Gly  Lys Lys Trp 
    1130                 1135                 1140             


Arg Arg  Pro Phe Glu Ala Arg  Tyr Gly Asp Ala Tyr  Met Ala Met 
    1145                 1150                 1155             


Val Ala  Gln Leu Phe Asp Gly  Thr Val Thr Ser Pro  Pro Ala Lys 
    1160                 1165                 1170             


Gly Pro  Pro Gln Ser Gly Lys  Ser Gly Gly Lys Pro  Gly Lys Gly 
    1175                 1180                 1185             


Ala Glu  Gly Gly Ala Lys Glu  Lys Ser Arg Ser Pro  Thr Arg Met 
    1190                 1195                 1200             


Glu Glu  Gly Gly Val Tyr Glu  Gly Arg Val Ala Lys  Ala Lys Ser 
    1205                 1210                 1215             


Asp Lys  Gly Phe Gly Phe Leu  Leu Val Glu Gly Ala  Gln Glu Glu 
    1220                 1225                 1230             


Ile Phe  Leu His Ile Tyr Gly  Ile Ser Gly Asn Arg  Pro Ala Arg 
    1235                 1240                 1245             


Ile Glu  Asn Gly Gln Arg Tyr  Arg Phe Thr Leu Gly  Ile Asp Arg 
    1250                 1255                 1260             


Asp Arg  Glu Arg Arg Lys Glu  Arg Ala Trp Val Ala  Arg Glu Ala 
    1265                 1270                 1275             


Val Arg  Ile Asp Glu Asn Arg  Ser Lys 
    1280                 1285         


<210>  600
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  600

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Thr Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Asp Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val His Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1400                 1405                 1410         


<210>  601
<211>  1358
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  601

Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser Val Ala 
1               5                   10                  15      


Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu Tyr Tyr 
            20                  25                  30          


Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp Leu Glu 
        35                  40                  45              


Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr Asn Val 
    50                  55                  60                  


Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln Lys Met 
65                  70                  75                  80  


Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn Ala Leu 
                85                  90                  95      


Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val Glu Lys 
            100                 105                 110         


Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys Met Lys 
        115                 120                 125             


Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe Pro Glu 
    130                 135                 140                 


Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser Lys Glu 
145                 150                 155                 160 


Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys Leu Lys 
                165                 170                 175     


Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg Met Gln 
            180                 185                 190         


Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu Tyr Gly 
        195                 200                 205             


Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe Glu Lys 
    210                 215                 220                 


Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile Val Lys 
225                 230                 235                 240 


Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys Asp Gly 
                245                 250                 255     


Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys Lys Tyr 
            260                 265                 270         


Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys Glu Lys 
        275                 280                 285             


Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr Leu Cys 
    290                 295                 300                 


Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp Met Thr 
305                 310                 315                 320 


Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu Asn Glu 
                325                 330                 335     


Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn Leu Lys 
            340                 345                 350         


Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala Val Asn 
        355                 360                 365             


Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile Arg Glu 
    370                 375                 380                 


Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr Ile Asp 
385                 390                 395                 400 


Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp Gly Tyr 
                405                 410                 415     


Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu Trp Thr 
            420                 425                 430         


Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val Tyr His 
        435                 440                 445             


Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro Ile Ser 
    450                 455                 460                 


Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly Phe Asp 
465                 470                 475                 480 


Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met Glu Lys 
                485                 490                 495     


Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr Pro Glu 
            500                 505                 510         


Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met Lys Thr 
        515                 520                 525             


Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln Lys Lys 
    530                 535                 540                 


His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp Ala Asp 
545                 550                 555                 560 


Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg Glu Lys 
                565                 570                 575     


Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr Lys Glu 
            580                 585                 590         


Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His Tyr Thr 
        595                 600                 605             


Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala Glu Tyr 
    610                 615                 620                 


Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg Glu Lys 
625                 630                 635                 640 


Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val Ile Asn 
                645                 650                 655     


Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala Ala Gln 
            660                 665                 670         


Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro Gln Val 
        675                 680                 685             


Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met Asn Cys 
    690                 695                 700                 


Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe Phe Val 
705                 710                 715                 720 


Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys Lys Pro 
                725                 730                 735     


Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys Leu Ser 
            740                 745                 750         


Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser Phe Gly 
        755                 760                 765             


Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala Ile Cys 
    770                 775                 780                 


Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile Ser Met 
785                 790                 795                 800 


Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys Gln Ile 
                805                 810                 815     


Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu Ala Phe 
            820                 825                 830         


Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro Val Leu 
        835                 840                 845             


Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp Gly Leu 
    850                 855                 860                 


Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn Asp Ala 
865                 870                 875                 880 


Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn Gln Lys 
                885                 890                 895     


Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln Phe Thr 
            900                 905                 910         


Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val Asp Asn 
        915                 920                 925             


Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu Ile Leu 
    930                 935                 940                 


Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met Glu Asp 
945                 950                 955                 960 


Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly Phe Val 
                965                 970                 975     


Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala Leu Tyr 
            980                 985                 990         


Ser Phe Cys Lys Gln Lys Phe Lys  Val Asp Gly Lys Glu  Tyr Met Ala 
        995                 1000                 1005             


Gly Ile  Tyr Tyr Asp Gly Glu  Asn Leu Ile Pro Asn  Arg Asn Ile 
    1010                 1015                 1020             


Ile Arg  Ala Asn Met Tyr Gly  Asn Thr Ser Cys Leu  Lys Pro Cys 
    1025                 1030                 1035             


Met Asp  Arg Ile Thr Leu Lys  Glu Ile Arg Thr Met  Tyr Ala Asp 
    1040                 1045                 1050             


Gln Asn  Lys Leu Asp Leu Val  Leu Lys Glu Gly Val  Cys His Thr 
    1055                 1060                 1065             


Glu Glu  Glu Gln Lys Ala Tyr  Arg Glu Tyr Gln Asn  Glu Lys Asn 
    1070                 1075                 1080             


Arg Ile  Glu Leu Phe Asp Val  Cys Thr Tyr Thr Gln  Ile Leu Asn 
    1085                 1090                 1095             


Asp Met  Gln Ala Arg Leu Ile  Gly Trp Ser Tyr Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Met Tyr Tyr Gln Leu  Gly Tyr Tyr Tyr Thr  Lys Leu Phe 
    1115                 1120                 1125             


Trp Thr  Asp Ser Ile Ser Glu  Glu Asp Ala Arg Arg  Arg Leu Val 
    1130                 1135                 1140             


Gly Asn  Leu Val Asn Val Glu  Asp Gly Ala Ile Leu  Tyr Gln Ile 
    1145                 1150                 1155             


Leu Ala  Phe Asn Ser Tyr Asn  Leu Pro Ile Ile Ala  Asn Lys Asn 
    1160                 1165                 1170             


Asn Thr  Val Thr Leu Leu Lys  Asp Glu Gly Ser Ile  Gly Gly Lys 
    1175                 1180                 1185             


Ala Ile  Thr Ala Phe Phe Lys  Asn Tyr Glu Asn Ala  Glu Met Ile 
    1190                 1195                 1200             


Tyr Glu  Glu Ala Leu Asp Leu  Phe Glu Asn Met Asp  Glu His Ala 
    1205                 1210                 1215             


Ala Ile  Ile Asn Thr Arg Asn  Tyr Ile Glu His Phe  Lys Tyr Phe 
    1220                 1225                 1230             


Ile Lys  Ser Asp Arg Ser Met  Met Asp Leu Tyr Ser  Glu Ile Tyr 
    1235                 1240                 1245             


Asp Arg  Phe Phe Arg His Asp  His Asn Arg Lys Lys  Asn Val Pro 
    1250                 1255                 1260             


Asp Ser  Leu Lys Asn Val Leu  Ala Asp Asn Phe Met  Ile Val Asp 
    1265                 1270                 1275             


Ile Asp  Met Glu Leu Gly Ser  Lys Lys Val Gly Glu  Lys Lys Lys 
    1280                 1285                 1290             


Gly Phe  Arg Glu His Lys Ala  Ala Arg Ile Glu Phe  Thr Asp Ser 
    1295                 1300                 1305             


Gly Ile  Arg Ser Thr Asp Met  Thr Tyr Thr Ile Lys  Pro Asp Ile 
    1310                 1315                 1320             


Lys Asp  Asn Lys Lys Asp Lys  Lys Val Leu Val Pro  Ala Arg Ser 
    1325                 1330                 1335             


Glu Val  Phe Leu Lys Gln Phe  Arg Lys Ile Leu Glu  Tyr Arg Ile 
    1340                 1345                 1350             


Gln Asp  Lys Ile Gln 
    1355             


<210>  602
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  602

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Thr Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Asp Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Ser Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val His Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1400                 1405                 1410         


<210>  603
<211>  1246
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  603

Met Tyr Met Lys Ile Thr Lys Ile Asp Gly Val Ser His Tyr Lys Glu 
1               5                   10                  15      


Lys Glu Lys Gly Val Leu Lys Gly Lys Asp Ile Leu Asn Gly Lys Ile 
            20                  25                  30          


Glu Lys Ile Val Lys Lys Arg Tyr Asp Ala Thr Ile Glu Ser Lys Ile 
        35                  40                  45              


Tyr Lys Glu Phe Ile Lys Leu Arg Lys Asn Arg Ile Glu Gln Asn Asn 
    50                  55                  60                  


Glu Lys Ser Ile Leu Glu Leu Ile Lys Ser Asn Ile Asp Lys Asn Glu 
65                  70                  75                  80  


Lys Glu Ile Lys Thr Leu Leu Trp Lys Asn Phe Lys Ile Lys Glu Lys 
                85                  90                  95      


Asn Lys Asn Tyr Asp Glu Tyr Ile Thr Asp Glu Ile Lys Leu Asp Asn 
            100                 105                 110         


Asp Ile Lys Ile Tyr Glu Ser Val Glu Ser Leu Tyr Phe Leu Ile Lys 
        115                 120                 125             


Glu Ile Tyr Leu Gly Gln Asn Asn Lys Lys Trp Asn Ile Ser Lys Ile 
    130                 135                 140                 


Asp Leu Glu Lys Ile Met Glu Glu Asp Ser Asp Leu Ile Met Leu Gly 
145                 150                 155                 160 


Tyr Lys Leu Lys Lys Asn Ile Lys Glu Asp Asp Tyr Pro Tyr Leu Tyr 
                165                 170                 175     


Arg Asp Lys Asn Gly Gln Glu Ser Thr Ser Val Tyr Lys Leu Leu Lys 
            180                 185                 190         


Lys Leu Ile Glu Glu Asn Lys Asp Arg Asn Gln Asp Ile Arg Lys Ser 
        195                 200                 205             


Gln Glu Tyr Glu Lys Ile Arg Lys Asn Phe Glu Glu Tyr Lys Asn Arg 
    210                 215                 220                 


Lys Ile Asn Leu Leu Val Lys Ser Ile Lys Asn Asn Lys Ile Asn Ile 
225                 230                 235                 240 


Gln Tyr Ile Asn Asn Glu Ile Lys Ser His Asp Asn Pro Arg Glu Glu 
                245                 250                 255     


Asn Ile Ile Lys Phe Phe Arg Lys Met Ile Glu Glu Lys Asn Lys Pro 
            260                 265                 270         


Ile Leu Lys Asp Lys Leu Lys Leu Phe Arg Leu Glu Val Phe Phe Asn 
        275                 280                 285             


Glu Glu Phe Leu Glu Glu Ile Lys Lys Leu Leu Asp Ser Asp Asp Ser 
    290                 295                 300                 


Asp Lys Ser Gln Asn Lys Lys Ile Ser Glu Leu Arg Gly Lys Ile Phe 
305                 310                 315                 320 


Asn Arg Ile Arg Glu Glu Ile Lys Asn Asn Lys Asn Arg Asp Glu Leu 
                325                 330                 335     


Glu Asn Ile Tyr Phe Leu Glu Leu Lys Lys Tyr Ile Glu Asn Asn Leu 
            340                 345                 350         


Ser His Lys Lys Glu Lys Asn Lys Asn Ser Asn Asn Thr Gly Glu Glu 
        355                 360                 365             


Lys Ser Lys Lys Leu Tyr Leu Lys Phe Leu Lys Lys Val Leu Phe Ile 
    370                 375                 380                 


Asp Asp Asn Asn Arg Ile Ser Ile Glu Lys Leu Lys Ser Arg Ile Asp 
385                 390                 395                 400 


Asp Asn Phe Lys Asn Leu Leu Ile Gln His Val Ile Glu Tyr Gly Lys 
                405                 410                 415     


Ile Lys Tyr Tyr Val Glu Asn Asp Asp Tyr Ile Arg Asn Ile Val Lys 
            420                 425                 430         


Asn Gly Glu Leu Lys Leu Glu Thr Lys Asp Leu Glu Tyr Ile Lys Thr 
        435                 440                 445             


Lys Glu Thr Leu Ile Arg Lys Met Ala Val Leu Val Ser Phe Ala Ala 
    450                 455                 460                 


Asn Ser Tyr Tyr Asn Leu Phe Gly Ser Ala Ser Glu Asp Ile Leu Gly 
465                 470                 475                 480 


Thr Glu Val Val Lys Asn Arg Arg Thr Asn Val Ile Lys Val Lys Ser 
                485                 490                 495     


Tyr Ile Phe Lys Glu Lys Met Leu Asn Tyr Phe Phe Asp Ser Glu Asp 
            500                 505                 510         


Phe Asp Val Asn Lys Thr Ile Glu Val Leu Glu Ser Ile Ser Tyr Ser 
        515                 520                 525             


Ile Tyr Asn Ile Arg Asn Gly Val Gly His Phe Asn Lys Leu Val Leu 
    530                 535                 540                 


Gly Lys Tyr Lys Lys Lys Asp Ile Ser Thr Asn Lys Arg Val Glu Glu 
545                 550                 555                 560 


Asp Leu Asn Asn Asn Glu Glu Ile Lys Gly Tyr Phe Ile Lys Lys Arg 
                565                 570                 575     


Gly Glu Ile Glu Lys Lys Ile Lys Glu Arg Phe Leu Ser Asn Asn Leu 
            580                 585                 590         


Gln Tyr Tyr Tyr Ala Lys Glu Arg Ile Glu Asn Tyr Phe Glu Val Tyr 
        595                 600                 605             


Glu Phe Glu Ile Leu Lys Glu Lys Ile Pro Phe Ala Pro Asn Phe Lys 
    610                 615                 620                 


Arg Ile Ile Lys Lys Gly Glu Asn Leu Leu Asn Asn Lys Lys Tyr Glu 
625                 630                 635                 640 


Tyr Phe Lys Asn Phe Asp Lys Asn Ser Val Glu Glu Lys Lys Glu Phe 
                645                 650                 655     


Leu Lys Thr Arg Asn Phe Leu Leu Lys Glu Leu Tyr Tyr Asn Asn Phe 
            660                 665                 670         


Tyr Lys Glu Phe Leu Ser Lys Lys Glu Glu Phe Lys Lys Ile Val Ile 
        675                 680                 685             


Glu Val Lys Glu Glu Lys Lys Asn Arg Gly Asn Asn Lys Lys Ser Gly 
    690                 695                 700                 


Val Ser Phe Gln Ser Ile Asp Asp Tyr Asp Thr Lys Ile Asn Ile Ser 
705                 710                 715                 720 


Asp Tyr Ile Ala Ser Ile His Lys Lys Glu Met Glu Arg Val Glu Lys 
                725                 730                 735     


Tyr Asn Glu Glu Lys Gln Lys Asp Thr Ala Lys Tyr Ile Arg Asp Phe 
            740                 745                 750         


Val Glu Glu Ile Phe Leu Thr Gly Phe Ile Asn Tyr Leu Glu Lys Asp 
        755                 760                 765             


Lys Arg Leu His Phe Leu Lys Glu Glu Phe Ser Ile Leu Cys Asn Asn 
    770                 775                 780                 


Asn Asn Val Val Asp Phe Asn Ile Asn Ile Asn Glu Glu Lys Ile Lys 
785                 790                 795                 800 


Glu Phe Leu Lys Glu Asn Asp Ser Lys Thr Leu Asn Leu Tyr Leu Phe 
                805                 810                 815     


Phe Asn Met Ile Asp Ser Lys Arg Ile Ser Glu Phe Arg Asn Glu Leu 
            820                 825                 830         


Ile Lys Tyr Lys Gln Phe Thr Lys Lys Arg Leu Asp Glu Glu Lys Glu 
        835                 840                 845             


Phe Leu Gly Ile Lys Ile Glu Leu Tyr Glu Thr Leu Ile Glu Phe Val 
    850                 855                 860                 


Ile Leu Thr Arg Glu Lys Leu Asp Thr Lys Lys Ser Glu Glu Thr Asp 
865                 870                 875                 880 


Ala Trp Leu Val Asp Lys Leu Tyr Val Lys Glu Lys Asn Glu Cys Asn 
                885                 890                 895     


Glu Tyr Glu Tyr Lys Glu Tyr Glu Glu Ile Leu Lys Leu Phe Val Asp 
            900                 905                 910         


Glu Lys Ile Leu Asn Ser Lys Glu Ala Pro Tyr Tyr Ala Thr Asn Asn 
        915                 920                 925             


Lys Thr Pro Ile Leu Leu Ser Asn Phe Glu Lys Thr Arg Lys Tyr Gly 
    930                 935                 940                 


Thr Gln Ser Phe Leu Ser Glu Ile Gln Ser Asn Tyr Lys Tyr Ser Lys 
945                 950                 955                 960 


Val Glu Lys Glu Asn Ile Glu Asp Tyr Asn Lys Lys Glu Glu Ile Glu 
                965                 970                 975     


Lys Lys Lys Lys Ser Asn Ile Glu Lys Leu Gln Asp Leu Lys Val Glu 
            980                 985                 990         


Leu His Lys Lys Trp Glu Gln Asn  Lys Ile Thr Glu Lys  Glu Ile Lys 
        995                 1000                 1005             


Lys Tyr  Asn Asp Thr Ile Lys  Glu Ile Arg Glu Tyr  Asn Tyr Leu 
    1010                 1015                 1020             


Lys Asn  Lys Glu Glu Leu Gln  Asn Val Tyr Leu Leu  His Glu Ile 
    1025                 1030                 1035             


Leu Ser  Asp Leu Leu Ala Arg  Asn Val Ala Phe Phe  Asn Lys Trp 
    1040                 1045                 1050             


Glu Arg  Asp Phe Lys Phe Ile  Val Ile Ala Ile Lys  Gln Phe Leu 
    1055                 1060                 1065             


Arg Glu  Asn Asp Lys Glu Lys  Val Glu Asn Phe Leu  Asn Pro Leu 
    1070                 1075                 1080             


Asp Asn  Ser Lys Gly Lys Lys  Val Tyr Phe Ser Val  Ser Lys Tyr 
    1085                 1090                 1095             


Lys Asn  Thr Val Glu Asn Ile  Asp Gly Ile His Lys  Asn Phe Met 
    1100                 1105                 1110             


Asn Leu  Ile Phe Leu Asn Asn  Lys Phe Met Asn Arg  Lys Ile Asp 
    1115                 1120                 1125             


Lys Met  Asn Cys Thr Ile Trp  Val Tyr Phe Arg Asn  Tyr Ile Ala 
    1130                 1135                 1140             


His Phe  Leu His Leu His Thr  Lys Asn Glu Lys Ile  Ser Leu Ile 
    1145                 1150                 1155             


Asn Gln  Met Asn Leu Leu Ile  Lys Leu Phe Ser Tyr  Asp Lys Lys 
    1160                 1165                 1170             


Val Gln  Asn His Ile Leu Lys  Ser Thr Lys Thr Leu  Leu Glu Lys 
    1175                 1180                 1185             


Tyr Asn  Ile Gln Ile Asn Phe  Glu Ile Ser Asn Asp  Lys Asn Glu 
    1190                 1195                 1200             


Val Phe  Lys Tyr Lys Ile Lys  Asn Arg Leu Tyr Ser  Lys Lys Gly 
    1205                 1210                 1215             


Lys Met  Leu Gly Lys Asn Asn  Lys Phe Glu Ile Leu  Glu Asn Glu 
    1220                 1225                 1230             


Phe Leu  Glu Asn Val Lys Ala  Met Leu Glu Tyr Ser  Glu 
    1235                 1240                 1245     


<210>  604
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  604

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Thr Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Tyr Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asn Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Val Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Val 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Lys Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Met 
    690                 695                 700                 


Tyr Ile Gly Asn Asp Glu Gln Ile Asn Thr Ser Leu Ala Gly Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Lys Ile Leu Lys Tyr Thr Glu Ser Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Lys Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Leu Lys Glu Leu Lys Glu Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn Tyr Thr Met Gln Gln Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Lys Lys Asp Glu Lys Phe Asn Asp Glu Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Ile Met Lys Ser  Val Val Asn Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Lys Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Lys Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Glu  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  605
<211>  1366
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  605

Met Lys Leu Ser Lys Glu Asn His Ile Arg Ser Ala Val Val Ile Ser 
1               5                   10                  15      


Gly Lys Glu Gly Asn Ile Ala Gly Thr Leu Tyr Lys Ile Pro Gly Glu 
            20                  25                  30          


Gly Thr Val Asp Leu Lys Lys Trp Met Leu Glu Arg Asp Lys Ala Val 
        35                  40                  45              


Lys Ser Leu Tyr Asn Ile Phe Asn Gln Ile Gln Leu Gly Asn Glu Pro 
    50                  55                  60                  


Lys Glu Trp Lys Glu Asn Arg Asn Leu Ser Thr Glu Glu Asn Thr Arg 
65                  70                  75                  80  


Arg Met His Gln Lys Lys Val Lys Ile Gln Asn Tyr Lys Met Lys Lys 
                85                  90                  95      


Ala Cys Ser Arg Tyr Val Asn Thr Ile Ser Arg Thr Ile Asn Glu Leu 
            100                 105                 110         


Leu Phe Phe Tyr Lys Thr Thr Lys Thr Thr Gln Asn Asn Lys Val Lys 
        115                 120                 125             


Tyr Asp Lys Leu Lys Met Met His Lys Asn Glu Asp Ile Ile Ser Lys 
    130                 135                 140                 


Met Lys Asn Glu Asn Ile Leu Gln Gln Phe Lys Val Glu Gly Lys Asn 
145                 150                 155                 160 


Gly Lys Leu Glu Lys Gly Lys Leu Glu Asp Phe Val Thr Leu Ala Leu 
                165                 170                 175     


Arg Ser Ser Leu Val Val Ser Arg Tyr Lys Gly Lys Asp Phe Asp Ser 
            180                 185                 190         


Val Ala Ala Val Ala Val Phe Leu Glu Asn Ile Gly Asn Asn Asn Ile 
        195                 200                 205             


Ser His Glu Asp Glu Arg Thr Ile Asn Ile Leu Leu Asp Leu Ile Arg 
    210                 215                 220                 


Glu Asp Phe Thr Lys Leu Asn Pro Asn Ile Asp Asn Thr Met Gly Ala 
225                 230                 235                 240 


Arg Leu Ile Arg Ser Val Thr Asn Gln Asn Met Leu Val Gln Pro Gln 
                245                 250                 255     


Asn Asp Arg Phe Ser Phe Pro Cys Val His Asp Ser Gly Lys Ser Lys 
            260                 265                 270         


Val Ser Asn Lys Asn Val Glu Lys Ser Gly Leu Asp Asn Phe Leu Leu 
        275                 280                 285             


Asp Tyr Ala Asn Leu Asp Lys Asp Ile Arg Glu Asn Tyr Leu Arg Lys 
    290                 295                 300                 


Leu Arg Arg Ile Ile Asp Ile Tyr Phe Ser Ala Pro Ile Thr Tyr Gln 
305                 310                 315                 320 


Lys Asp Met Asp Val Ala Leu Ser Glu Val Val Val Lys Asp Lys Phe 
                325                 330                 335     


Asp Val Trp Lys Lys His Asn Glu Gly Lys Lys Asp Asn Asn Thr Phe 
            340                 345                 350         


Val Lys Val Pro Glu Val Leu Ile Lys Ala Glu Thr Asp His Glu Lys 
        355                 360                 365             


Leu Asp Thr Val Ile Glu Lys Gln Ala Arg Lys Glu Leu Ala Asp Arg 
    370                 375                 380                 


Val Arg Glu Gln Asn Met Thr Cys Tyr Arg Tyr Thr Gln Ala Val Val 
385                 390                 395                 400 


Lys Lys Tyr Asn Ala Lys Glu Ala Leu Phe Phe Glu Asn Asp Asp Ile 
                405                 410                 415     


Asn Gln Tyr Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu 
            420                 425                 430         


Lys Ser Cys Lys Ile Gly Thr Leu Phe Lys Leu His Asn Gly Tyr Leu 
        435                 440                 445             


Ile Glu Lys Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr 
    450                 455                 460                 


Ile Ala Leu Gly Lys Val Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp 
465                 470                 475                 480 


Asn Asp Asn Lys Val Lys Arg Leu Gly Asp Ile Ser Glu Lys Ile Arg 
                485                 490                 495     


Ser Gly Ile Thr Ser Phe Asp Tyr Glu Met Leu Lys Ala Gln Glu Thr 
            500                 505                 510         


Leu Gln Arg Glu Leu Ala Val Asn Val Ala Phe Ser Ala Asn Asn Leu 
        515                 520                 525             


Ala Arg Ala Val Cys Asn Met Ser Ala Leu Ser Asp Lys Thr Ser Asp 
    530                 535                 540                 


Phe Leu Leu Trp Gln Pro Asp Asp Ile Asn Asn Lys Met Lys Lys Ser 
545                 550                 555                 560 


Thr Gly Asn Asp Glu Asp Asn Glu Lys Asn Lys Arg Ala Val Cys Ala 
                565                 570                 575     


Val Leu Gln Phe Phe Gly Gly Lys Ser Leu Trp Asn Asp Val Asp Phe 
            580                 585                 590         


Glu Lys Ala Tyr Lys Asn Ala Gly Lys His Gly Tyr Gly Val Tyr Phe 
        595                 600                 605             


Ile Asn Asp Leu Arg Lys Ala Ile Phe Ala Ala Arg Asn Glu Ser Phe 
    610                 615                 620                 


His Phe Lys Thr Ala Ser Val Asn Asn Glu Lys Trp Asn Val Glu Phe 
625                 630                 635                 640 


Leu Gly Arg Met Phe Glu Lys Glu Thr Glu Phe Cys Leu Asp Ile Glu 
                645                 650                 655     


Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Met Phe Tyr Lys Ser Ser 
            660                 665                 670         


Asn Leu Glu Lys Met Leu Asn His Phe Tyr Ser Lys Asn Ile Ser Arg 
        675                 680                 685             


Ala Ala Gln Val Leu Ser Tyr Asn Thr Val Phe Val Arg Lys Thr Phe 
    690                 695                 700                 


Pro Glu Tyr Val Asn Asn Val Leu Lys Tyr Lys Lys Pro Gly Thr Asp 
705                 710                 715                 720 


Ala Glu Ile Leu Asp Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu Leu Lys 
                725                 730                 735     


Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Lys Asp Ala Phe Lys Tyr 
            740                 745                 750         


Phe Glu Asn Ala Val Tyr Asn Leu Asn Ser Lys Asn Ile Asn His Asp 
        755                 760                 765             


Ser Ser Gly Gln Lys Leu Ser Arg Asp Glu Met Lys Arg Lys Lys Ala 
    770                 775                 780                 


Ala Glu Ser Phe Gln Arg Arg Phe Val Glu Ile Lys Arg Val Ser Asp 
785                 790                 795                 800 


Ser Ser Ile Ser Tyr Val Cys Gln Val Phe Met Thr Asp Tyr Asn Gln 
                805                 810                 815     


Gln Asn Asn Gln Asn Lys Lys Val Arg Ser Ser Asn Asp Ser Leu Leu 
            820                 825                 830         


Asp Lys Pro Ile Tyr Gln His Phe Lys Met Leu Leu Lys Glu Thr Ile 
        835                 840                 845             


Lys Ser Ala Phe Ala Ala Tyr Leu Lys Asp Asn Asn Asn Lys Asp Leu 
    850                 855                 860                 


Phe Gly Phe Ile Gly Glu Pro Leu Lys Ile Asn Lys Asn Asp Asp Val 
865                 870                 875                 880 


Lys Val Ile Lys Lys Glu Glu Phe Leu Pro Asp Trp Lys Ser Glu Lys 
                885                 890                 895     


Tyr Ser Leu Leu Ile Glu Lys Val Lys Lys Ser Pro Lys Leu Gln Met 
            900                 905                 910         


Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met 
        915                 920                 925             


Ala Gly Ser Met Arg Ser Tyr Leu Gln Tyr Val Ser Asp Ile Asn Arg 
    930                 935                 940                 


Arg Ala Asn Val Val Gly Asn Lys Leu His Val Glu Val Leu Asp Lys 
945                 950                 955                 960 


Asp Thr Val Lys Asp Trp Ile Gln Val Ile Glu Val Cys Leu Leu Leu 
                965                 970                 975     


Ala Ser Arg Thr Ser Asn Gln Phe Asp Asp Tyr Phe Asn Asp Gly Asp 
            980                 985                 990         


Asp Tyr Ala Gly Tyr Leu Lys Ser  Tyr Val Asp Phe Ser  Asp Lys Asn 
        995                 1000                 1005             


Met Pro  Ser Ala Tyr Ser Ala  Leu Val Tyr Phe Ser  Asp Gln Gly 
    1010                 1015                 1020             


Lys Ile  Asp Leu Tyr Ile Asp  Pro Lys Asn Pro Lys  Ile Asn Arg 
    1025                 1030                 1035             


Asn Ile  Val Gln Ser Lys Leu  Phe Ala Ala Asp His  Ile Leu Gly 
    1040                 1045                 1050             


Asn Gly  Gln Ile Val Gln Pro  Val Ser Lys Asp Asp  Ile Ala Glu 
    1055                 1060                 1065             


Phe Tyr  Asn Leu Lys Ala Lys  Ile Ala Asp Ser Lys  Ile Lys Gly 
    1070                 1075                 1080             


Glu Asn  Ile Ser Glu Lys Glu  Gln Arg Asn Ile Leu  Arg Tyr Gln 
    1085                 1090                 1095             


Arg Leu  Lys Asn Lys Val Glu  Leu Arg Asp Ile Val  Glu Tyr Gly 
    1100                 1105                 1110             


Glu Ile  Ile Asn Glu Leu Leu  Gly Gln Leu Ile Asn  Trp Ser Phe 
    1115                 1120                 1125             


Met Arg  Glu Arg Asp Leu Leu  Tyr Phe Gln Leu Gly  Phe His Tyr 
    1130                 1135                 1140             


Asn Cys  Leu Arg Asn Asn Ser  Glu Lys Pro Glu Glu  Tyr Lys Lys 
    1145                 1150                 1155             


Ile Glu  Ala Asp Asp Ile Ser  Ile Asn Asp Ala Val  Leu Tyr Gln 
    1160                 1165                 1170             


Ile Ile  Gly Met Tyr Val Asn  Gly Ile Pro Val Tyr  Thr Ser Asp 
    1175                 1180                 1185             


Asn Asn  Lys Leu Lys Gly Glu  Cys Ala Asn Gly Gly  Ala Gly Gly 
    1190                 1195                 1200             


Lys Ile  Thr Ala Phe Cys Glu  Tyr Ser Glu Tyr Leu  Gly Phe Lys 
    1205                 1210                 1215             


Lys Ala  Thr Leu Tyr Glu Ser  Gly Leu Glu Leu Phe  Glu Val Leu 
    1220                 1225                 1230             


Ala Glu  His Asp Asp Ile Ile  Lys Leu Arg Asn Gly  Ile Glu His 
    1235                 1240                 1245             


Phe Lys  Tyr Tyr Leu Gly Asn  Tyr Arg Ser Ile Met  Ser Leu Tyr 
    1250                 1255                 1260             


Ser Glu  Val Phe Asp Arg Phe  Phe Thr Tyr Asp Leu  Lys Tyr Gln 
    1265                 1270                 1275             


Lys Asn  Val Leu Asn Leu Leu  Gln Asn Ile Leu Leu  Arg His Asn 
    1280                 1285                 1290             


Ile Val  Ile Val Pro Glu Phe  Glu Ser Gly Thr Lys  Lys Val Gly 
    1295                 1300                 1305             


Lys Asn  Ile Lys Gln Ser Ala  Lys Ile Ser Ile Lys  Asn Ile Gln 
    1310                 1315                 1320             


Ser Asp  Lys Phe Thr Tyr Lys  Ile Lys Gly Gly Thr  Thr Ser Ile 
    1325                 1330                 1335             


Asp Ala  Lys Asp Asp Arg Tyr  Leu Glu Thr Ile Lys  Lys Ile Leu 
    1340                 1345                 1350             


Tyr Tyr  Pro Glu Tyr Asp Lys  Asp Ser Gly Gly Val  Cys 
    1355                 1360                 1365     


<210>  606
<211>  1315
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  606

Met Ala Glu Thr Leu Thr Phe Thr Asn Leu Tyr Asp Ile Leu Thr Leu 
1               5                   10                  15      


Ile Asp Ser Gly Leu Asn Leu His Ile Asn Leu Gly Val Ile Ile Met 
            20                  25                  30          


Lys Leu Thr Arg Arg Arg Ile Ser Gly Asn Ser Val Asp Gln Lys Ile 
        35                  40                  45              


Thr Ala Ala Phe Tyr Arg Asp Met Ser Gln Gly Leu Leu Tyr Tyr Asp 
    50                  55                  60                  


Ser Glu Asp Asn Asp Cys Thr Asp Lys Val Ile Glu Ser Met Asp Phe 
65                  70                  75                  80  


Glu Arg Ser Trp Arg Gly Arg Ile Leu Lys Asn Gly Glu Asp Asp Lys 
                85                  90                  95      


Asn Pro Phe Tyr Met Phe Val Lys Gly Leu Val Gly Ser Asn Asp Lys 
            100                 105                 110         


Ile Val Cys Glu Pro Ile Asp Val Asp Ser Asp Pro Asp Asn Leu Asp 
        115                 120                 125             


Ile Leu Ile Asn Lys Asn Leu Thr Gly Phe Gly Arg Asn Leu Lys Ala 
    130                 135                 140                 


Pro Asp Ser Asn Asp Thr Leu Glu Asn Leu Ile Arg Lys Ile Gln Ala 
145                 150                 155                 160 


Gly Ile Pro Glu Glu Glu Val Leu Pro Glu Leu Lys Lys Ile Lys Glu 
                165                 170                 175     


Met Ile Gln Lys Asp Ile Val Asn Arg Lys Glu Gln Leu Leu Lys Ser 
            180                 185                 190         


Ile Lys Asn Asn Arg Ile Pro Phe Ser Leu Glu Gly Ser Lys Leu Val 
        195                 200                 205             


Pro Ser Thr Lys Lys Met Lys Trp Leu Phe Lys Leu Ile Asp Val Pro 
    210                 215                 220                 


Asn Lys Thr Phe Asn Glu Lys Met Leu Glu Lys Tyr Trp Glu Ile Tyr 
225                 230                 235                 240 


Asp Tyr Asp Lys Leu Glu Ala Asn Ile Thr Asn Arg Leu Asp Lys Thr 
                245                 250                 255     


Asp Lys Asn Ala Arg Ser Ile Ser Arg Ala Val Ser Asp Glu Leu Arg 
            260                 265                 270         


Glu Tyr His Lys Tyr Leu Arg Thr Asn Tyr Asn Arg Phe Val Ser Gly 
        275                 280                 285             


Asp Arg Pro Ala Ala Gly Leu Asp Asn Gly Gly Ser Ala Lys Tyr Asn 
    290                 295                 300                 


Pro Asp Lys Glu Glu Phe Leu Leu Phe Leu Lys Glu Val Glu Gln Tyr 
305                 310                 315                 320 


Phe Lys Lys Tyr Phe Pro Val Lys Ser Lys His Ser Asn Lys Ser Lys 
                325                 330                 335     


Asp Lys Ser Leu Val Asp Lys Tyr Lys Asn Tyr Cys Ser Tyr Lys Val 
            340                 345                 350         


Val Lys Lys Glu Val Asn Arg Ser Ile Ile Asn Gln Leu Val Ala Gly 
        355                 360                 365             


Leu Ile Gln Gln Gly Lys Leu Leu Tyr Tyr Phe Tyr Tyr Asn Asp Thr 
    370                 375                 380                 


Trp Gln Glu Asp Phe Leu Asn Ser Tyr Gly Leu Ser Tyr Ile Gln Val 
385                 390                 395                 400 


Glu Glu Ala Phe Lys Lys Ser Val Met Thr Ser Leu Ser Trp Gly Ile 
                405                 410                 415     


Asn Arg Leu Thr Ser Phe Phe Ile Asp Asp Ser Asn Thr Val Lys Phe 
            420                 425                 430         


Asp Asp Ile Thr Thr Lys Arg Ala Lys Glu Ala Ile Glu Ser Asn Tyr 
        435                 440                 445             


Phe Asn Lys Leu Arg Thr Cys Ser Arg Met Gln Asp His Phe Lys Glu 
    450                 455                 460                 


Lys Leu Ala Phe Phe Tyr Pro Val Tyr Val Lys Asp Lys Lys Asp Arg 
465                 470                 475                 480 


Pro Asp Asp Ile Glu Lys Leu Ile Val Leu Val Lys Asn Ala Ile Glu 
                485                 490                 495     


Ser Val Ser Tyr Leu Arg Asn Arg Ile Phe His Phe Lys Lys Ser Ser 
            500                 505                 510         


Leu Leu Glu Leu Leu Lys Glu Leu Asp Asp Lys Asn Ser Gly Gln Asp 
        515                 520                 525             


Lys Ile Asp Tyr Ser Val Ala Ala Glu Phe Ile Lys Arg Asp Ile Glu 
    530                 535                 540                 


Asn Leu Tyr Asp Val Phe Arg Glu Gln Ile Arg Ser Leu Gly Ile Ala 
545                 550                 555                 560 


Glu Tyr Tyr Lys Ala Asp Met Ile Ser Asp Cys Phe Lys Thr Cys Gly 
                565                 570                 575     


Leu Glu Phe Ala Leu Tyr Ser Pro Lys Asn Ser Leu Met Pro Ala Phe 
            580                 585                 590         


Lys Asn Val Tyr Lys Arg Gly Ala Asn Leu Asn Lys Ala Tyr Ile Arg 
        595                 600                 605             


Asp Lys Gly Pro Lys Glu Thr Gly Asp Gln Gly Gln Asn Ser Tyr Lys 
    610                 615                 620                 


Ala Leu Glu Glu Tyr Arg Glu Leu Thr Trp Tyr Ile Glu Val Lys Asn 
625                 630                 635                 640 


Asn Asp Gln Ser Tyr Asn Ala Tyr Lys Asn Leu Leu Gln Leu Ile Tyr 
                645                 650                 655     


Tyr His Ala Phe Leu Pro Glu Val Arg Glu Asn Glu Ala Leu Ile Thr 
            660                 665                 670         


Asp Phe Ile Asn Arg Thr Lys Glu Trp Asn Arg Lys Glu Thr Glu Glu 
        675                 680                 685             


Arg Leu Asn Thr Lys Asn Asn Lys Lys His Lys Asn Phe Asp Glu Asn 
    690                 695                 700                 


Asp Asp Ile Thr Val Asn Thr Tyr Arg Tyr Glu Ser Ile Pro Asp Tyr 
705                 710                 715                 720 


Gln Gly Glu Ser Leu Asp Asp Tyr Leu Lys Val Leu Gln Arg Lys Gln 
                725                 730                 735     


Met Ala Arg Ala Lys Glu Val Asn Glu Lys Glu Glu Gly Asn Asn Asn 
            740                 745                 750         


Tyr Ile Gln Phe Ile Arg Asp Val Val Val Trp Ala Phe Gly Ala Tyr 
        755                 760                 765             


Leu Glu Asn Lys Leu Lys Asn Tyr Lys Asn Glu Leu Gln Pro Pro Leu 
    770                 775                 780                 


Ser Lys Glu Asn Ile Gly Leu Asn Asp Thr Leu Lys Glu Leu Phe Pro 
785                 790                 795                 800 


Glu Glu Lys Val Lys Ser Pro Phe Asn Ile Lys Cys Arg Phe Ser Ile 
                805                 810                 815     


Ser Thr Phe Ile Asp Asn Lys Gly Lys Ser Thr Asp Asn Thr Ser Ala 
            820                 825                 830         


Glu Ala Val Lys Thr Asp Gly Lys Glu Asp Glu Lys Asp Lys Lys Asn 
        835                 840                 845             


Ile Lys Arg Lys Asp Leu Leu Cys Phe Tyr Leu Phe Leu Arg Leu Leu 
    850                 855                 860                 


Asp Glu Asn Glu Ile Cys Lys Leu Gln His Gln Phe Ile Lys Tyr Arg 
865                 870                 875                 880 


Cys Ser Leu Lys Glu Arg Arg Phe Pro Gly Asn Arg Thr Glu Leu Glu 
                885                 890                 895     


Lys Glu Thr Glu Leu Leu Ala Glu Leu Glu Glu Leu Met Glu Leu Val 
            900                 905                 910         


Arg Phe Thr Met Pro Ser Ile Pro Glu Ile Ser Ala Lys Ala Glu Ser 
        915                 920                 925             


Gly Tyr Asp Thr Met Ile Lys Lys Tyr Phe Lys Asp Phe Ile Glu Lys 
    930                 935                 940                 


Lys Val Phe Lys Asn Pro Lys Thr Ser Asn Leu Tyr Tyr His Ser Asp 
945                 950                 955                 960 


Ser Lys Thr Pro Val Thr Arg Lys Tyr Met Ala Leu Leu Met Arg Ser 
                965                 970                 975     


Ala Pro Leu His Leu Tyr Lys Asp Ile Phe Lys Gly Tyr Tyr Leu Ile 
            980                 985                 990         


Thr Lys Lys Glu Cys Leu Glu Tyr  Ile Lys Leu Ser Asn  Ile Ile Lys 
        995                 1000                 1005             


Asp Tyr  Gln Asn Ser Leu Asn  Glu Leu His Glu Gln  Leu Glu Arg 
    1010                 1015                 1020             


Ile Lys  Leu Lys Ser Glu Lys  Gln Asn Gly Lys Asp  Ser Leu Tyr 
    1025                 1030                 1035             


Leu Asp  Lys Lys Asp Phe Tyr  Lys Val Lys Glu Tyr  Val Glu Asn 
    1040                 1045                 1050             


Leu Glu  Gln Val Ala Arg Tyr  Lys His Leu Gln His  Lys Ile Asn 
    1055                 1060                 1065             


Phe Glu  Thr Leu Tyr Arg Ile  Phe Arg Ile His Val  Asp Ile Ala 
    1070                 1075                 1080             


Ala Arg  Met Val Gly Tyr Thr  Gln Asp Trp Glu Arg  Asp Met His 
    1085                 1090                 1095             


Phe Leu  Phe Lys Ala Leu Val  Tyr Asn Gly Val Leu  Glu Glu Arg 
    1100                 1105                 1110             


Arg Phe  Glu Ala Ile Phe Asn  Asn Asn Asp Asp Asn  Asn Asp Gly 
    1115                 1120                 1125             


Arg Ile  Val Lys Lys Ile Gln  Asn Asn Leu Asn Asn  Lys Asn Arg 
    1130                 1135                 1140             


Glu Leu  Val Ser Met Leu Cys  Trp Asn Lys Lys Leu  Asn Lys Asn 
    1145                 1150                 1155             


Glu Phe  Gly Ala Ile Ile Trp  Lys Arg Asn Pro Ile  Ala His Leu 
    1160                 1165                 1170             


Asn His  Phe Thr Gln Thr Glu  Gln Asn Ser Lys Ser  Ser Leu Glu 
    1175                 1180                 1185             


Ser Leu  Ile Asn Ser Leu Arg  Ile Leu Leu Ala Tyr  Asp Arg Lys 
    1190                 1195                 1200             


Arg Gln  Asn Ala Val Thr Lys  Thr Ile Asn Asp Leu  Leu Leu Asn 
    1205                 1210                 1215             


Asp Tyr  His Ile Arg Ile Lys  Trp Glu Gly Arg Val  Asp Glu Gly 
    1220                 1225                 1230             


Gln Ile  Tyr Phe Asn Ile Lys  Glu Lys Glu Asp Ile  Glu Asn Glu 
    1235                 1240                 1245             


Pro Ile  Ile His Leu Lys His  Leu His Lys Lys Asp  Cys Tyr Ile 
    1250                 1255                 1260             


Tyr Lys  Asn Ser Tyr Met Phe  Asp Lys Gln Lys Glu  Trp Ile Cys 
    1265                 1270                 1275             


Asn Gly  Ile Lys Glu Glu Val  Tyr Asp Lys Ser Ile  Leu Lys Cys 
    1280                 1285                 1290             


Ile Gly  Asn Leu Phe Lys Phe  Asp Tyr Glu Asp Lys  Asn Lys Ser 
    1295                 1300                 1305             


Ser Ala  Asn Pro Lys His Thr  
    1310                 1315 


<210>  607
<211>  1287
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  607

Met Arg Ile Gly Lys Val Gln Gly Arg Thr Phe Thr Gly Phe Asp Asn 
1               5                   10                  15      


Ala Arg Gly Lys Thr Leu Arg Arg Arg Leu Leu Thr Arg Pro Asp Asn 
            20                  25                  30          


Glu Ala Arg Ser Leu Ser Glu His Leu Ala His Asp Pro Lys Ala Leu 
        35                  40                  45              


Ile Gly Gln Ala Ile Ser Arg Ile Asp Thr Ile Tyr Gln Lys Pro Lys 
    50                  55                  60                  


Thr Gly Lys Pro Thr Pro Glu Gln Phe Gly His Arg Asp Thr Leu Gly 
65                  70                  75                  80  


Trp Ala Tyr Trp Lys Leu Leu Val Ala Ser Tyr Pro Glu Val Glu Gly 
                85                  90                  95      


His Arg Asp Leu Phe Val Arg Arg Leu His Pro Tyr Gly Asp Thr Pro 
            100                 105                 110         


Pro Lys Ser His Gly Gln Lys Glu Gly Glu His Gln Lys Gly Gly Lys 
        115                 120                 125             


Pro Gln Leu Glu Gly Arg Trp His Gly Val Met Ala Gln His Gly Lys 
    130                 135                 140                 


Asn Pro Asp Gln Ile Ala Ala Arg Leu Phe Asp His Leu His Asn Ser 
145                 150                 155                 160 


Glu Leu Arg Phe Gly Gly Thr Ala Ser Gly Glu Pro Arg Thr Arg Pro 
                165                 170                 175     


Gly Lys Glu Ala Thr Pro Thr Gly Leu Ile Gly Ala Arg Ala Lys Thr 
            180                 185                 190         


Ile Glu His Ser Val Leu Pro Arg Asp Ala Lys Arg Phe Val Ala Glu 
        195                 200                 205             


Trp Arg Gly Glu Asp Gln Glu Arg Tyr Ala Gly Ala Arg Asp Ile Ala 
    210                 215                 220                 


Ala Ala Ile Ser Ala Gly Leu Asn Asp Lys Asp Gln Lys Ser Gly Ser 
225                 230                 235                 240 


Gly Arg Lys Ser Ala Val Ile Gly Lys Leu Leu Ser Asp His Leu Glu 
                245                 250                 255     


Thr Leu Thr Gly Asn Arg Lys Cys Arg Phe Asp Pro Lys Ser Thr Ala 
            260                 265                 270         


Glu Thr Leu Glu Leu Arg Asp Gly Glu Ser Val Asp Asp Arg Arg Arg 
        275                 280                 285             


Ile Leu Glu Leu His Ala Glu Val Lys Ala Thr Tyr Lys Arg Met Ala 
    290                 295                 300                 


Ala Trp Lys Pro Ala Lys Leu Pro Arg Asn Ser Asp Glu Leu Phe Arg 
305                 310                 315                 320 


Leu Val Arg Gln Gln Ala Asp Asn Arg Ile Leu Asn His Leu Val Arg 
                325                 330                 335     


Val Gly Arg Ile Ser Val Tyr Ser Glu Gln Ser Asp Ala Leu Ser Glu 
            340                 345                 350         


Ser Gln Phe Trp Thr Ser Gly Gly Gln Thr Gln Ile Lys Glu Ser Glu 
        355                 360                 365             


Val Phe Ala Arg Leu Trp Ile Gly Ala Ile Ser Arg Ala Ser Tyr Ser 
    370                 375                 380                 


Met Lys Ala Trp Leu Glu Pro Glu Gly Thr Val Phe Asn Pro Ser Ile 
385                 390                 395                 400 


Asn Asp Phe Asp Val Thr Ser Ser His Asn Thr Asn Arg Ile Leu Glu 
                405                 410                 415     


Asp Ser Gly Arg Leu Ser Asn Ala Met Ala Arg Arg Ala Ile Tyr Phe 
            420                 425                 430         


Gly Glu Thr Pro Glu Phe Asp Ala Leu Gly Glu Glu Asp Gln Arg Val 
        435                 440                 445             


Leu Val Lys Lys Cys Leu Asp Ala Leu Ser Ala Cys Arg Asn Arg Thr 
    450                 455                 460                 


Phe His His Gly Gln Arg Ala Lys Phe Leu Lys Glu Val Arg Lys Gly 
465                 470                 475                 480 


Leu Lys Glu Lys Glu Ala Asp Ser Ala Gly Pro Ala Ala Trp Glu Gly 
                485                 490                 495     


Ile Arg Glu Val Ile Gln Ala Asp Ala Arg Asn Leu Gly Ala Arg Leu 
            500                 505                 510         


Leu Gln Asp Leu Thr Gly Ala Lys Val His Ser Phe Ala Thr Asp Pro 
        515                 520                 525             


Glu Phe Arg His Leu Tyr Glu Ser Val Ala Ala Thr Leu Thr Ala Gly 
    530                 535                 540                 


Gly Glu Leu Glu Ala Ala Leu Pro Arg Leu Lys Asn Val Leu Lys Arg 
545                 550                 555                 560 


Ala Glu Gly Val Arg Cys Tyr Leu Asp Thr Pro Ser Gln Arg Arg Glu 
                565                 570                 575     


Gly Asp Glu Ser Leu Ile Ala Arg Leu Pro Val Ala Pro Val Pro Arg 
            580                 585                 590         


Glu Leu Asp Asp Ala Ala Thr Lys Ala Arg His Ser Ala Leu Leu Arg 
        595                 600                 605             


Leu Tyr Asp Gly Pro Phe Arg Pro Trp Ala Thr Glu Leu Arg Gly Glu 
    610                 615                 620                 


Arg Leu Ser Asp Tyr Ala Ala Arg Ala Lys Arg Leu Ala Thr Arg Leu 
625                 630                 635                 640 


Ala Lys Ser Thr Asn Thr Ala Ser Pro Tyr Pro Asp Ser Val Glu Gly 
                645                 650                 655     


Arg Ser Val Arg Leu Arg Asp Pro Ile Thr Ala Asp Thr Ala Pro Glu 
            660                 665                 670         


Thr Leu Lys Thr Tyr Leu Ser Ala Leu Thr Ala Glu Thr Ala Thr Glu 
        675                 680                 685             


Phe Arg Val Gln Lys Gly Tyr Glu Ser Asp Gly Glu Lys Ala Lys Glu 
    690                 695                 700                 


Gln Ala Glu Phe Ile Glu Asp Phe Arg Arg Asp Met Ile Ala Leu Ala 
705                 710                 715                 720 


Phe Gln Asp Phe Ile Arg Asp His Gly Phe Ala Trp Leu Leu Asp Ile 
                725                 730                 735     


Ala Ser Lys Ala Glu Pro Ser Asn Asp Ala Pro Asn Leu Pro Asp Pro 
            740                 745                 750         


Val Asp Thr Gly Lys Asp Thr Val Phe Glu Asp Trp Gln Ala Leu Leu 
        755                 760                 765             


Tyr Leu Phe Leu His Phe Val Pro Ala Asp Asp Val Ser Gln Leu Leu 
    770                 775                 780                 


His Gln Leu Arg Lys Trp Asp Ala Leu Gln Asp Lys Tyr Glu Leu Ala 
785                 790                 795                 800 


Glu Pro Gly Glu Thr Leu Gly Gln Thr Lys Ala Asp Thr Arg Lys Ile 
                805                 810                 815     


Val Gly Gln Phe Arg Asp Cys Leu Thr Leu Phe Leu Lys Thr Gly Asp 
            820                 825                 830         


Ala Arg Phe Asp Gly Glu Gly Val Glu Leu Pro Leu Ser Asp Phe Gln 
        835                 840                 845             


Glu Leu Phe Glu Ser Pro Ala Thr Phe Lys Glu Leu Phe Leu Ala Glu 
    850                 855                 860                 


Pro Ala Glu Asn Asp Ala Ser Glu Thr Asp Asp Gln Asp Ala Pro Gly 
865                 870                 875                 880 


Glu Lys His Arg Val Thr Arg Thr Arg Arg Gly Leu Arg Gln Ile Leu 
                885                 890                 895     


Arg Tyr Asn His Met Pro Val Leu Arg Asp Leu Phe Leu Ala His Lys 
            900                 905                 910         


Val Thr Asp Ala Glu Val Asp Gly Leu Gln Ala Leu Glu Val Asp Asp 
        915                 920                 925             


Pro Gln Thr Gly Glu Ser Gln Ile Gly Ala Ala Gln Arg Ile Arg Thr 
    930                 935                 940                 


Glu Ile His His His Thr Ser Asn Asp Lys Gln Ile Ser Glu Ala Lys 
945                 950                 955                 960 


Val Glu Glu Tyr Arg Arg Ala Leu Ser Thr Ile Glu Arg His Arg Phe 
                965                 970                 975     


Leu Val Gly Arg Val Tyr Leu Gly Asp His Ile Arg Val His Lys Leu 
            980                 985                 990         


Met Met Asp Val Met Gly Arg Leu  Val Asp Phe Ala Gly  Ala Trp Glu 
        995                 1000                 1005             


Arg Glu  Ala Ala Asp Gly Asp  Arg Lys Gly Phe Ile  Ser Arg Ala 
    1010                 1015                 1020             


Ile Ala  Leu Pro Glu Val Ala  Glu Gly Tyr Ala Ala  Asp Arg Leu 
    1025                 1030                 1035             


Lys Thr  Val Ala Arg Arg Val  Leu Asp Asp Gly Glu  Ala Arg Arg 
    1040                 1045                 1050             


Ile Arg  Asn Asp Leu Gly His  Phe Asn Asp Leu Ala  Pro Thr Ser 
    1055                 1060                 1065             


Gly Pro  Ala Asn Leu Thr Phe  Val Val Asn Arg Ala  Arg Arg Met 
    1070                 1075                 1080             


Met Arg  His Asp Arg Lys Arg  Lys Asn Ala Val Thr  Lys Ser Val 
    1085                 1090                 1095             


Ile Glu  Ile Leu Asn Arg Gln  Gly Leu Gly Ile Glu  Trp Thr Met 
    1100                 1105                 1110             


Arg Asn  His Glu Leu Cys Glu  Ala Lys Leu Trp Gln  Asn Pro Val 
    1115                 1120                 1125             


Lys His  Leu Gly Phe Ala Thr  Leu Glu Gly Arg Gly  Lys Lys Trp 
    1130                 1135                 1140             


Arg Arg  Pro Phe Glu Ala Arg  Tyr Gly Asp Ala Tyr  Met Ala Met 
    1145                 1150                 1155             


Val Ala  Gln Leu Phe Asp Gly  Thr Val Thr Ser Pro  Pro Ala Lys 
    1160                 1165                 1170             


Gly Pro  Pro Gln Ser Gly Lys  Ser Gly Gly Lys Pro  Gly Lys Gly 
    1175                 1180                 1185             


Ala Glu  Gly Gly Ala Lys Glu  Lys Ser Arg Ser Pro  Thr Arg Met 
    1190                 1195                 1200             


Glu Glu  Gly Gly Val Tyr Glu  Gly Arg Val Ala Lys  Ala Lys Ser 
    1205                 1210                 1215             


Asp Lys  Gly Phe Gly Phe Leu  Leu Val Glu Gly Ala  Gln Glu Glu 
    1220                 1225                 1230             


Ile Phe  Leu His Ile Tyr Gly  Ile Ser Gly Asn Arg  Pro Ala Arg 
    1235                 1240                 1245             


Ile Glu  Asn Gly Gln Arg Tyr  Arg Phe Thr Leu Gly  Ile Asp Arg 
    1250                 1255                 1260             


Asp Arg  Glu Arg Arg Lys Glu  Arg Ala Trp Val Ala  Arg Glu Ala 
    1265                 1270                 1275             


Val Arg  Ile Asp Glu Asn Arg  Ser Lys 
    1280                 1285         


<210>  608
<211>  1373
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  608

Met Ala Lys His Leu Arg Pro Ile Gly Glu Ser Tyr Thr Asp Phe Leu 
1               5                   10                  15      


Asp Glu Thr Glu Phe Val Arg Leu Gly Arg Gly Leu His Arg Gly His 
            20                  25                  30          


His Gly Val Gln Ile Pro Pro Thr Glu Leu Pro Ser Tyr Leu Ala Glu 
        35                  40                  45              


Tyr Arg Lys Ala Leu Met Arg Gln Val Val Ala Val Leu Asp Lys Val 
    50                  55                  60                  


Val Gly Lys Arg Arg Arg Leu Ser Gly Met His Pro Glu Ala Tyr Arg 
65                  70                  75                  80  


Asp Arg Val His Leu Ala Glu Ala Leu Trp Val Arg Leu Val Ala Arg 
                85                  90                  95      


Val Lys Glu Ile Gly Thr Pro Pro Asp Pro Ser Glu Leu Leu Asp Leu 
            100                 105                 110         


Arg Arg Met Trp Asn Ala Lys Ala His Pro Tyr Ala Glu Tyr Asp Val 
        115                 120                 125             


Val Pro Arg Ala Pro Leu Asn Asp Gly Asn Gly Gln Lys Ile Leu Glu 
    130                 135                 140                 


Cys Arg Glu Val Asp Asp Pro Lys Ile Glu Arg Ser Asp Phe Glu Gly 
145                 150                 155                 160 


Arg Trp His Gly Arg Phe Trp Gln Ser Glu Pro Gly Pro Val Asp Tyr 
                165                 170                 175     


Asn Ala Ile Ala Asp Arg Ile Phe Ala His Leu Phe Asp Gln Glu Ala 
            180                 185                 190         


Val Ile Gly Gly Gly Pro Arg Arg Glu Gly Asn Val Thr Val Pro Asp 
        195                 200                 205             


Glu Asp Ile Asn Gly Gln Pro Gly Pro Ala Thr Gly Lys Gly Leu Ile 
    210                 215                 220                 


Ile Ala Arg Gly Gln Ser Ile Val Lys Ser Ala Ser Asp Pro Arg Arg 
225                 230                 235                 240 


Ser Ser Lys Lys Val Gln Arg Thr Trp Asp Lys Ala Val Glu Arg Arg 
                245                 250                 255     


Tyr Phe Gly Asp Asp Gly Lys Gly Gly Ser Asp Ile Ala Lys Ala Ile 
            260                 265                 270         


Tyr Glu Glu Leu Gly Asp Pro Ala Thr Leu Ala Asp Pro Ile Tyr Ala 
        275                 280                 285             


Ser Trp Phe Gly Ser Arg Leu Tyr Asp His Phe Gly Ser Phe Lys Asn 
    290                 295                 300                 


Ser Leu Pro Leu Glu Leu Lys Asp Pro Phe Lys Glu Gln Ile Trp Ala 
305                 310                 315                 320 


Leu His Asn Ser Val Arg Gln Phe Tyr Gln Arg Met Ala Lys Ser Asp 
                325                 330                 335     


Arg Phe Arg Leu Ala Leu Gln Asn Ala Arg Ser Glu Val Pro Asp Arg 
            340                 345                 350         


Ser Glu Leu Leu Ala Leu Leu Pro Lys Asp His Asp His Leu Leu Leu 
        355                 360                 365             


Val Leu Gly Gly Lys Lys Lys Asn Ala Glu Met Ser Glu Leu Ile Arg 
    370                 375                 380                 


Leu Gly Lys Leu Phe Val His Ala Ser Asp Val Leu His Asp Phe Asp 
385                 390                 395                 400 


Ala Asn Asp Ala Ala Ala Leu Asp Ala Phe Lys Arg Arg Met Ser Phe 
                405                 410                 415     


Leu Ala Thr Ser Ile Gly Gln Ser Glu Ile Lys Gln Thr Glu Thr Phe 
            420                 425                 430         


Ala Arg Thr Trp Arg Gly Ala Val Gly Leu Thr Leu Arg Thr Val Lys 
        435                 440                 445             


Gly Leu Ala Asp Pro Arg Gly Ile Ile Gly Thr Pro Asp Asn Arg Asp 
    450                 455                 460                 


Leu Gly Thr Ala Gly Pro Met Lys Asp Ala Phe Asn Lys Phe Asp Gln 
465                 470                 475                 480 


Pro His Phe Gln Gln His Met Thr Ile Ile Phe Gly Asn Lys Glu Leu 
                485                 490                 495     


Gln Ala Glu Gly Asn Pro Thr Arg Ser Ser Val Phe Thr Ala Asn Gly 
            500                 505                 510         


Asp Lys Asp His Gln Ala Glu Leu Leu Trp Gly Phe Leu Cys Val Val 
        515                 520                 525             


Arg Ser Val Arg Asn Arg Thr Asn His Tyr Asn Val Arg Arg Ala Leu 
    530                 535                 540                 


Leu Arg Leu Leu Asp Glu Gly Ile Val Ser Pro Met Pro Ser Asp Pro 
545                 550                 555                 560 


Lys Lys Glu Arg Val Glu Asn Arg Asn Leu Cys Thr Val Ser Pro Thr 
                565                 570                 575     


Ala Leu Glu Ala Phe Arg Arg Leu Leu Asn Phe Asp Leu Ala Ile Gln 
            580                 585                 590         


Lys Glu Ala Val Arg Thr Ala Leu Glu Gln Ala Lys Ala Ser Glu Phe 
        595                 600                 605             


Val Glu Glu Gly Lys Leu Arg Gly Leu Val Ser Glu Leu Ala Gly Thr 
    610                 615                 620                 


Glu Asp Met Pro Ala Leu His Ile Pro Arg Phe Ser Ala Val Met Asp 
625                 630                 635                 640 


Lys Val Arg Arg Leu Ala Asp Asn Arg Asp Val Gly Leu Asp Pro Ile 
                645                 650                 655     


Leu Ser Thr Leu Gln Arg Ser Leu Pro Pro Thr Asp Lys Gln Ala Glu 
            660                 665                 670         


Ser Asp Ala Ala Arg Cys Arg Tyr Arg Leu Leu Leu Glu Leu Tyr Lys 
        675                 680                 685             


Ser Gly Phe Arg Ser Trp Phe Ser Gly Ile Gln Ser Asn Glu Glu Asn 
    690                 695                 700                 


Asn Arg Glu Ile Cys His Trp Ala Val Lys Gln Val Gly Arg Ala Lys 
705                 710                 715                 720 


Asp Ala Arg Lys Ser Glu Tyr Asp Lys Lys Thr Lys Arg His Tyr Arg 
                725                 730                 735     


Ser Pro Asn Ser Leu Ile Asp Asp Leu Gly Leu Asp Lys Phe Asp Asp 
            740                 745                 750         


Leu Thr Asp Leu Leu Glu Ala Leu Ala Ser Gln Ser Thr Arg Glu His 
        755                 760                 765             


Asp Gln Asn Leu Lys Tyr Val Pro Asp Ala Arg Val Gln Ser Gln Met 
    770                 775                 780                 


Ser Asn Arg Ile Glu Glu Phe Arg Gln Glu Leu Phe Ala His Ile Phe 
785                 790                 795                 800 


Thr Lys Tyr Leu Asp Thr His Asp Phe Gly Trp Ile Gly Ala Ile Glu 
                805                 810                 815     


Val Arg Arg Glu Ala Cys Asp Leu Ala Asp Val Val Ser Ala Phe Glu 
            820                 825                 830         


Val Arg Asp Gln Lys Phe Asp Ala Asp Trp His Ser Gln Phe Tyr Ala 
        835                 840                 845             


Trp Leu Tyr Met Val Pro Pro Ile Glu Ala Ser Arg Leu Arg His Gln 
    850                 855                 860                 


Met Arg Lys Ser Ala Val Met Asp Asp Lys Trp Ser Thr Thr Leu Glu 
865                 870                 875                 880 


Leu Thr Ser Gly Asp Arg Lys Thr Arg Asp Asp His Ala Gln Asp Val 
                885                 890                 895     


Leu Ala Asp Met Asp Arg Leu Phe Ser Leu Tyr Thr Lys Val Gln Ala 
            900                 905                 910         


Ala Gly Phe Asn Gly Gln Glu His Glu Ser Ala Leu Gly Ser Lys Ser 
        915                 920                 925             


Leu Phe Tyr Glu Asp Gly Asn Gln Phe Asp Glu Val Tyr Ser Pro Asp 
    930                 935                 940                 


Thr Glu Thr His Asn Lys Thr Phe Pro Gly Thr Arg Arg Gly Leu Arg 
945                 950                 955                 960 


Gln Leu Val Arg Tyr Ala His Leu Pro Ala Leu Glu Gly Val Phe Lys 
                965                 970                 975     


Lys His Arg Ile Thr Lys Ala Glu Val Glu Thr Phe Val Ala Leu Tyr 
            980                 985                 990         


Asp Glu Asn Arg Arg Asp Pro Gly  Ser Val Ala His Met  Leu Arg Arg 
        995                 1000                 1005             


Glu Lys  Leu Arg Thr Glu Ile  Leu Arg Ser Ile His  Asp Gly Pro 
    1010                 1015                 1020             


Lys Pro  Lys Asp Lys Asp Phe  Trp Pro Lys Leu Glu  Ala Lys Cys 
    1025                 1030                 1035             


Leu Glu  Tyr Arg Thr Val Ala  Thr Glu Thr Ala Ile  Tyr Asn Phe 
    1040                 1045                 1050             


Gln Ala  Asn Ala Ala Arg Leu  Asn Asp His Ala Arg  Leu His Gln 
    1055                 1060                 1065             


Ile Val  Met Arg Val Val Ala  Arg Leu Thr Asp Tyr  Ala Leu Ile 
    1070                 1075                 1080             


Trp Glu  Arg Asp Arg Leu Phe  Ala Phe Val Gly Met  Leu Tyr Arg 
    1085                 1090                 1095             


Gln Thr  Gly Gly Thr Gly Ile  Asn Pro Ala Met Arg  His Ala Glu 
    1100                 1105                 1110             


Lys Thr  Asn Ala Pro Pro Arg  Ile Gly Ile Leu Val  Ser Asp Ser 
    1115                 1120                 1125             


Ala Leu  Ala Lys Lys Leu Asn  Ser Asn Ser Ala Glu  Val Phe Ile 
    1130                 1135                 1140             


Pro Tyr  Leu Asp Thr Glu Thr  Gly Phe Asp Ala Pro  Arg Phe Asp 
    1145                 1150                 1155             


Asp Leu  Cys Thr Leu Leu Ser  His Glu His Ala Lys  Glu Phe Arg 
    1160                 1165                 1170             


Phe His  Phe Leu Glu Val Gly  Glu Glu Asn Ser Lys  Asp Glu Ala 
    1175                 1180                 1185             


Arg Arg  Leu Asn Glu Glu Thr  Met Gly His Arg Lys  Arg Pro Ala 
    1190                 1195                 1200             


Phe Lys  Arg Gly Thr Arg Arg  Gln Gly Ile Arg Asn  Asp Leu Ala 
    1205                 1210                 1215             


His His  Asn Val Leu Asp Leu  Ala Gly Gly Ala Gly  Pro Asn Leu 
    1220                 1225                 1230             


Thr Tyr  Val Val Asn Ala Val  Arg Ser Leu Leu Ser  Tyr Asp Arg 
    1235                 1240                 1245             


Lys Leu  Lys Asn Ala Val Pro  Lys Ser Ile Lys Arg  Ile Leu Gly 
    1250                 1255                 1260             


Glu Glu  Gly Leu Ile Ile Glu  Trp Gln Met Asn Tyr  Asp Arg Leu 
    1265                 1270                 1275             


Lys Lys  Pro Thr Val Tyr Pro  Asn Val Glu Thr His  Leu Thr Met 
    1280                 1285                 1290             


Val Pro  Pro Arg His Met Thr  Ala Pro Val Ser Phe  Thr Leu Pro 
    1295                 1300                 1305             


Arg Ala  Ser Val Arg Leu Ala  Ser Met Val Lys Ala  Val Phe Asp 
    1310                 1315                 1320             


Phe Gly  Ser Ser Gly Tyr Gly  Glu Glu Arg Met Ile  Gly Gly Arg 
    1325                 1330                 1335             


Thr Ala  Lys Gln Ala Val Tyr  Pro Asp Asp Phe Thr  Arg Arg Phe 
    1340                 1345                 1350             


Pro Gln  Thr Pro Met Gly Leu  Lys Gln Ala Thr Arg  Leu Val Phe 
    1355                 1360                 1365             


Ala Ser  Glu Asn Ser 
    1370             


<210>  609
<211>  1245
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  609

Met Arg Ile Val Arg Pro Tyr Gly Arg Ser Phe Val Asp His Asp Pro 
1               5                   10                  15      


Gly Gly Ala Leu Gln Arg Lys Val Glu Leu Arg Ala Pro Val Ser Ala 
            20                  25                  30          


Glu Gly Gly Pro Arg Gln Leu Asp Leu Gly His Phe Ala Leu Thr His 
        35                  40                  45              


Asp Glu Leu Val Ile Ala Gln Trp Val Ser Cys Ile Asp Lys Ile Ala 
    50                  55                  60                  


Thr Lys Pro Arg Glu Gly Arg Glu Pro Ser Gly Asp Gln Arg Glu Phe 
65                  70                  75                  80  


Arg His His Leu Gly Asn Ala Ala Trp Gly His Leu Glu Thr His Gly 
                85                  90                  95      


Leu Leu Ser Gly Leu Arg Asp Pro Gln Lys Arg Ala Arg Leu Ala Lys 
            100                 105                 110         


Leu Trp Gln Met Lys Ile Ala Pro Tyr Asp Phe Ser Ala Arg Thr Arg 
        115                 120                 125             


Arg Ser Arg Gly Pro Gln Gly Val Asp Ala Pro Ala Lys Gly Arg Trp 
    130                 135                 140                 


Phe Gly Val Phe Ala Gly Asp Val Ser Val Gln Glu Ala Asp Cys Gly 
145                 150                 155                 160 


Ala Ile Val Ala Arg Ile His Glu His Leu Tyr Glu Ser Gln Tyr Arg 
                165                 170                 175     


Leu Gly Glu Glu Thr Pro Leu Arg Ser Ala Gly Leu Ile Ala Arg Arg 
            180                 185                 190         


Ala Gly Ala Ile Thr Thr Ser Val Ala Pro Asp Ala Ala Lys Pro Ser 
        195                 200                 205             


Val Ala Thr Trp Ser Glu Ala Asp Leu Ala Arg Tyr Arg Ser Ala Gly 
    210                 215                 220                 


Asp Val Ala Cys Lys Ile Arg Arg Ala Ala Arg Glu Arg Glu Gln Gly 
225                 230                 235                 240 


Arg Asp Gly Ala Gly Thr Arg Arg Val Thr Asn Ser Val Ala Gly Lys 
                245                 250                 255     


Val Leu Phe Asp His Trp Arg Ala Leu Phe Ser Asp Glu Gly Gly Thr 
            260                 265                 270         


Val Arg Ser Phe Arg Asp Val Glu Gly His Asp Pro Gly Leu Ala Ala 
        275                 280                 285             


Leu His Asn Ala Val Arg Glu Cys Tyr Ala Arg Ile Leu Lys Arg His 
    290                 295                 300                 


Lys Lys Lys Pro Pro Gly Arg Asp Ala Gly Pro Glu Ser Ser Ala Ile 
305                 310                 315                 320 


Leu Arg Ala Leu Pro Arg Asp Met Asp Ala Leu Leu Thr Arg Ile Asp 
                325                 330                 335     


Ser Gly Arg Arg Asn Arg Asp Leu Ala Ala Lys Val Arg Leu Gly Lys 
            340                 345                 350         


Leu Ile His Tyr Thr Ala Ser Asp Pro Ala His Asp Arg Ala Gly Ala 
        355                 360                 365             


Val Ala Glu Arg Trp Pro Gly Asp Val Ala Asp Ser Arg Tyr Arg Thr 
    370                 375                 380                 


Ser Ala Gly Gln Ala Glu Ile Lys Arg Asn Glu Ala Phe Val Arg Val 
385                 390                 395                 400 


Trp Arg His Val Leu Val Leu Ala Ala Arg Thr Leu Glu Asn Trp Ala 
                405                 410                 415     


Asp Pro Glu Asn Arg Ile Asn Arg Asp Ile Leu Ser Ser Gly Gly Ala 
            420                 425                 430         


Lys Ala Ala Cys Glu Gln Phe Glu Ser Ser Arg Phe Met His Lys Cys 
        435                 440                 445             


Asn Val Leu Phe Gly Glu Arg Ala Gly His Phe Ile Gly Gln Asp Asp 
    450                 455                 460                 


Ala Ala Leu Gln Lys Ala Val Leu Glu Leu Ala Leu Glu Arg Leu Gly 
465                 470                 475                 480 


Gln Leu Arg Asn Arg Ser Phe His Phe Thr Gly Arg Gly Gly Phe Leu 
                485                 490                 495     


Glu Val Leu Gln Gln Leu Gly Gln Pro Ala Glu Lys Ala Pro Cys Gln 
            500                 505                 510         


Ser Ala His Asp Arg Thr Met Ala Ser Leu Arg Ala Leu Trp Arg Asp 
        515                 520                 525             


Asp Asp Glu Gly Arg Gly Gly Arg Leu Lys Ala Thr Met Thr Gly Ala 
    530                 535                 540                 


His Phe Glu Thr Phe Leu Asp Glu Ala Gln Ile Arg Arg Phe Phe Asp 
545                 550                 555                 560 


Gln Val Ser Thr Gly Gln Glu Ala Glu Pro Pro Leu Pro Arg Phe Gly 
                565                 570                 575     


Arg Val Leu Gln Arg Ala Lys Asn Thr Arg Asp Ala Gln Ser Asp Leu 
            580                 585                 590         


Arg Pro His Leu Pro Asp Pro Gly Asn Met Arg Thr Leu Glu Asp Pro 
        595                 600                 605             


Ala Arg Leu Cys Gln Tyr Thr Ala Leu Lys Leu Leu Tyr Ala Lys Pro 
    610                 615                 620                 


Phe Arg Thr Trp Leu Ala Glu Ala Asp Ser Ala Val Ile Asn Pro Phe 
625                 630                 635                 640 


Ile Glu Ala Ala Val Thr Arg Ala Arg Arg Glu Ala Gln Lys Ile Trp 
                645                 650                 655     


Ala Ala Arg Thr Gly His His Gly Val Asp Glu Glu Ala Lys Ala Leu 
            660                 665                 670         


Ile Gln Pro Arg Met Ala Met Ile Gly Arg Leu Ala Pro Gly Glu Asn 
        675                 680                 685             


Ile Gln Thr Leu Phe Phe Arg Met Ser Ala Glu Thr Ala Thr Glu Met 
    690                 695                 700                 


Arg Val Gln Ala Gly Tyr Glu Ser Asp Pro Asp Ala Ala Arg Glu Gln 
705                 710                 715                 720 


Ala Glu Phe Ile Glu Asn Leu Lys Cys Asp Val Ile Ala Gln Ala Phe 
                725                 730                 735     


Met Arg Phe Leu Asp Glu Ala Gly Phe Asp Phe Leu Leu Thr Leu Asp 
            740                 745                 750         


Ala Arg Ala Ala Arg Pro Glu Ser Ala Arg Phe Asp Leu Ala Met Leu 
        755                 760                 765             


Asp Ala Ala Ala Arg Ala Glu Glu Pro Gln Asp Trp Met Leu Val Leu 
    770                 775                 780                 


Tyr Phe Leu Leu His Leu Val Pro Val Asp Glu Ala Gly Arg Leu Leu 
785                 790                 795                 800 


His Gln Leu Arg Lys Trp Glu Ile Leu Ala Gly Pro Glu Glu Ala Gly 
                805                 810                 815     


Ala Arg Thr Gly Ala Asp Ala Ala Asn Ser Thr Leu Ser Gly Leu Tyr 
            820                 825                 830         


Gln Val Leu Asp Leu Tyr Leu Asp Met His Asp Ala Lys Phe Ser Gly 
        835                 840                 845             


Gly Ala Ala Leu Tyr Gly Ala Arg His Phe Arg Asn Leu Phe Glu Asp 
    850                 855                 860                 


Glu Ala Asp Phe Asp Arg Leu Phe Pro Val Ala Asp Ala Gly Glu Glu 
865                 870                 875                 880 


Asp Lys Arg Ile Pro Leu Arg Gly Leu Arg Glu Ile Leu Arg Phe Gly 
                885                 890                 895     


Asp Arg Ala Thr Leu Glu Ala Ile Tyr Ala Gln Asn Arg Ile Arg Pro 
            900                 905                 910         


Ala Glu Val Ala Glu Val Leu Asp Leu Glu Ala Pro Asp Ala Asp Gly 
        915                 920                 925             


Met Ser Arg Ile Ala Gly His His Ala Arg Arg Glu Lys Leu His Ala 
    930                 935                 940                 


Gln Trp Val Glu Ala Lys Gln Ser Phe Asp Asp Asp Ala Val Arg Asp 
945                 950                 955                 960 


Tyr Phe Val Ala Leu Gly Gln Val Val Arg His Arg His Leu Ala Ala 
                965                 970                 975     


Arg Ala Arg Leu Val Asp His Val Arg Leu His Arg Leu Met Met Asn 
            980                 985                 990         


Val Leu Gly Arg Leu Ala Asp Phe  Ala Gly Leu Trp Glu  Arg Asp Val 
        995                 1000                 1005             


Tyr Phe  Val Met Leu Ala Thr  Leu Tyr Glu Gln Gly  Thr Ser Pro 
    1010                 1015                 1020             


Ala Ala  Val Leu Asn Cys Glu  Ala Arg Arg Lys Leu  Ser Gln Gly 
    1025                 1030                 1035             


Arg Ile  Val Glu Val Ile Arg  Ala Leu Lys Pro Val  Asp Gly Gly 
    1040                 1045                 1050             


Ala Leu  Tyr Ala Ala Ile Thr  Gly His Phe Pro Gly  Phe Asp Thr 
    1055                 1060                 1065             


Arg Arg  Asn Asp Asp Pro Val  Gln Leu Arg Asn Asn  Phe Ala His 
    1070                 1075                 1080             


Phe Asn  Met Leu Arg Gln Gly  His Met Pro Asp Leu  Thr Ala Cys 
    1085                 1090                 1095             


Val Asn  Arg Ala Arg Arg Leu  Met Ala Tyr Asp Arg  Lys Leu Lys 
    1100                 1105                 1110             


Asn Ala  Val Ser Lys Ala Val  Ile Glu Leu Leu Ala  Arg Glu Gly 
    1115                 1120                 1125             


Leu Thr  Leu Ser Trp Arg Met  Asp Ala Arg Gly Pro  Gln His Asp 
    1130                 1135                 1140             


Leu Thr  Glu Ala Arg Ile Thr  Ala Arg Thr Ala Thr  His Leu Gly 
    1145                 1150                 1155             


Gly Ile  Arg Leu Thr Gln Arg  Gly Gly Ser Thr Gly  Ser Arg Pro 
    1160                 1165                 1170             


Phe Pro  Leu Thr Glu Ala Leu  His Gly Thr Gly Phe  Ala Arg Met 
    1175                 1180                 1185             


Val Ala  Gln Leu Phe Ala Gly  Gln Asp Arg Pro Ser  Arg Cys Val 
    1190                 1195                 1200             


Ser Gln  Asp Asp Pro Thr Thr  Ile Glu Arg Ala Pro  Ala Arg Asn 
    1205                 1210                 1215             


Thr Asn  Arg Lys Glu Ser Ala  Lys Lys Arg Met Lys  Pro Gly Arg 
    1220                 1225                 1230             


Asp Gly  Gly Arg Arg His Glu  Lys Ser Arg Arg Gly  
    1235                 1240                 1245 


<210>  610
<211>  1144
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  610

Met Lys Leu Ser Ile Gly Gly Phe Met Lys Val Cys Lys Ile Gly Gly 
1               5                   10                  15      


Thr Lys Phe Ala Ala Val Pro His Gly Val Leu Tyr Gly Arg Asn Phe 
            20                  25                  30          


Gly Asp Asn Glu Asn Pro Lys Ser Ile Leu Asn Gln Lys Glu Asp Ile 
        35                  40                  45              


Asn Asn Phe Val Ile Lys Arg Leu Glu Glu Val Lys Ile Asn Gly Thr 
    50                  55                  60                  


Val Phe Thr Lys Leu Gln Asn Asp Glu Ser Lys His Phe Ser Gln Glu 
65                  70                  75                  80  


Met Glu Arg Met Tyr Asp Asp Lys Lys Val Phe Ser Leu Lys Asp Phe 
                85                  90                  95      


Leu Ser Leu Lys Ala Tyr Thr Glu Lys Asn Lys Ala Phe Leu Asn Arg 
            100                 105                 110         


Gln Ile Glu Lys Thr Ile Leu Pro Phe Phe Ala Val Leu Gln Asp Lys 
        115                 120                 125             


Ile Gly Glu Val Asp Leu Asn Lys Ile Asp Tyr Lys Ser Ala Tyr Ser 
    130                 135                 140                 


Asp Glu Lys Thr Lys Asn Phe Gln Lys Glu Leu Glu Phe Phe Arg Lys 
145                 150                 155                 160 


Lys Ser Lys Phe Ile Lys Glu Pro Lys Pro Tyr Asn Ala Glu Asn Ile 
                165                 170                 175     


Thr Asn Ser Ile Ile Lys Gln Arg Thr Phe Val Cys Tyr Lys Asn Asn 
            180                 185                 190         


Gln Phe Cys Phe Asn Gly Asn Lys Asn Asn Phe Gly Leu Glu Ala Phe 
        195                 200                 205             


Leu Thr Lys Phe Ala Lys Asn Pro Lys Glu Ile Lys Asp Leu Phe Asn 
    210                 215                 220                 


Met Val Lys Val Glu Leu Phe Gly Phe Leu Asp Asp Ser Ser Lys Asp 
225                 230                 235                 240 


Met Pro Phe Ile Asp Leu Asn Lys Val Asn Lys Ser Glu Leu Asp Asn 
                245                 250                 255     


Ile Arg Asn Glu Lys Asp Lys Lys Glu Tyr Leu Asn Lys Glu Leu Ser 
            260                 265                 270         


Thr Leu Ile Thr Asn Lys Leu Gly Glu Leu Ser Gly Lys Ile Lys Lys 
        275                 280                 285             


Leu Lys Asp Gln Thr Asn Asp Leu Glu Asn Lys Asn Phe Lys Leu Phe 
    290                 295                 300                 


Trp Phe Tyr Lys Ser Tyr Glu Phe Thr Lys Ala Leu Ile Lys Ser Val 
305                 310                 315                 320 


Ser Lys Lys Tyr Thr Tyr Val Phe Lys Arg Asp Tyr Asn Lys Glu Glu 
                325                 330                 335     


Glu Arg Lys Glu Lys Glu Lys Ile Lys Val Glu Arg Phe Thr Asn Gln 
            340                 345                 350         


Phe Val Leu Asn His Val Leu Gly Lys Leu Lys Asn Tyr Ile Cys Ser 
        355                 360                 365             


Lys Ile Ile Ala Leu Gly Lys Ala Leu Asn Leu Lys Tyr Asp Thr Ala 
    370                 375                 380                 


Asn Lys Lys Leu Ile Glu Asn Asp Leu Thr Ser Ile Asp Phe Glu Thr 
385                 390                 395                 400 


Gln Lys Ala Tyr Asp Ser Val Lys Gln Ser Gln Tyr Val Ala Ile Ser 
                405                 410                 415     


Phe Ser Lys Asn Thr Met Ile Asn Ile Leu Lys Pro Gln Pro Gln Lys 
            420                 425                 430         


Glu Phe Phe Leu Glu Ser Gln Ser Phe Ala Lys Asn Ile Asn Asp Lys 
        435                 440                 445             


Tyr Ile Leu Phe Lys Gly Asn Ile Asn Asn Gly Ile Glu Cys Asn Phe 
    450                 455                 460                 


Gln Glu Lys Asp Ile Glu Lys Tyr Phe Phe Pro Asn Val Phe Ser Gly 
465                 470                 475                 480 


Val Asn Glu Val Asp Phe Ile Asn Glu Ser Ile Glu Ala Ile Asp Ser 
                485                 490                 495     


Leu Arg Asn Asp Asn Phe His Phe Phe Glu Ser Asn Ala Asn Pro Thr 
            500                 505                 510         


Ile Tyr Thr Ile Lys Glu Val Val Lys Lys Glu Ile Lys Lys Leu Asn 
        515                 520                 525             


Glu Val Val Ile Glu Lys Leu Asn Ser Val Glu Ala Lys Arg Tyr Phe 
    530                 535                 540                 


Phe Val Lys Asp Ile Asn Asn Leu Ile Asn Lys Ala Tyr Glu Asn Ala 
545                 550                 555                 560 


Ser Ser Val Leu Ser Tyr Ile Pro Lys Phe Thr Ser Ile Phe Asn Gln 
                565                 570                 575     


Ile Lys Lys Glu Glu Ser Phe Thr Ser Ile Ile Ser Arg Ile Pro Ser 
            580                 585                 590         


Ser Glu Gly Ala Ile Glu Phe Leu Leu Glu Lys Leu Tyr Tyr His Asn 
        595                 600                 605             


Phe Leu Ser Ile Lys Asn Gly Thr Ile Ile Ala Asn Glu Phe Phe Trp 
    610                 615                 620                 


Glu Ala Ile Lys Lys Ala Lys Glu Lys Asp Phe Glu His Lys Lys Glu 
625                 630                 635                 640 


Ile Asp Ile Phe Cys Glu Val Phe Gly Ile Asp Ile Glu Ser Lys Thr 
                645                 650                 655     


Gly Phe Asp Ser Phe Asn Asn Leu Ser Cys Leu Ile Ser Gln Glu Val 
            660                 665                 670         


Ser Arg Leu Ile Asn Asp Ser Asn Lys Asp Gly Glu Phe Ile Lys Ile 
        675                 680                 685             


Phe Phe Val Lys Ile Ile Ser Glu Ala Phe Leu Leu Phe Val Asn Lys 
    690                 695                 700                 


Asn Tyr Ser Phe Val Phe Asn Pro Gln Val Ile Glu Ser Gln Glu Asn 
705                 710                 715                 720 


Phe Asn Ile Ser Ile Ile Lys Thr Ile Asp Glu Ser Ala Tyr Ser Met 
                725                 730                 735     


Tyr Leu Leu Ala Lys Leu Ile Pro Asn Ser Thr Leu Asn Phe Leu Ile 
            740                 745                 750         


Asn Asp Tyr Arg Lys Tyr Leu Gln Phe Phe Gln Asp Ile Asn Leu Arg 
        755                 760                 765             


Ser Asn Ser Leu Asn Gln Asn Glu Ile Glu Asn Thr Asn Glu Thr Ile 
    770                 775                 780                 


Ser Lys Cys Leu Asn Ile Ile Asn Ala Leu Ser Leu Ala Ser Glu Phe 
785                 790                 795                 800 


Lys Ser Tyr Glu Leu Ser Asn Phe Lys Asp Ile Asp Glu Lys Asn Lys 
                805                 810                 815     


Lys Thr Tyr Glu Leu Ile Ser Pro Tyr Ile Gly Cys Gln Glu Lys Ser 
            820                 825                 830         


Leu Lys Glu Phe Leu Ser Asn Pro Asn Tyr Asp Gly Val Tyr His Asp 
        835                 840                 845             


Gly Thr Asn Ile Ile Leu Gln Asn His Phe Ser Lys Leu Glu Phe Phe 
    850                 855                 860                 


Gly Ile Glu Lys Leu Leu Thr Gln Ile Val Lys Ser Ser Asn Tyr Ile 
865                 870                 875                 880 


Val Ser Ile Asp Glu Ile Lys Thr Tyr Lys Asn Phe Gln Ala Asp Lys 
                885                 890                 895     


Asp Val Lys Leu Gln Ser Lys Lys Ile Glu Asn Gln Asp Asp Ile Asn 
            900                 905                 910         


Lys Tyr Gln Asn Phe Ile Gln Asn Lys Asn Lys Val Glu Leu His Asp 
        915                 920                 925             


Ile Phe Ser Leu Asn Ser Leu Ile Ile Glu Ala Val Ser Ser Leu Ile 
    930                 935                 940                 


Glu Cys Ser Tyr Lys Trp Glu Arg Asp Ser Phe Tyr Phe Leu Phe Gly 
945                 950                 955                 960 


Leu Gln Tyr Leu Leu Lys Asn Asp Leu Cys Asp Ile Phe Thr Ile Phe 
                965                 970                 975     


Asp Tyr Asn Ser Thr Val Asn Pro Ala Thr Gly Glu Gly Lys Ala Val 
            980                 985                 990         


Thr Lys Lys Leu Glu Ser Phe Phe  Ser Asn Ser Leu Ile  Lys Asn Ile 
        995                 1000                 1005             


Tyr Glu  Asn Phe Phe Gly Ala  Phe Asp Ser Ile Arg  Pro Ile Gln 
    1010                 1015                 1020             


Lys Ser  Ile Lys Ser Ile Lys  Pro Ile Arg Asn Ser  Ile Asp His 
    1025                 1030                 1035             


Phe Asp  Tyr Ile Lys Lys Thr  Asn Glu Ser Ile Ile  Glu Met Phe 
    1040                 1045                 1050             


Ser Asp  Ala Arg Lys Leu Asn  Ser Tyr Asp Ile Lys  Ile Lys Asn 
    1055                 1060                 1065             


Gly Ile  Met Pro Lys Leu Tyr  His Ser Leu Glu Lys  Met Gln Leu 
    1070                 1075                 1080             


Lys Phe  His Ser Asp Phe Val  Asn Lys Asp Val Ile  Ser Ile Val 
    1085                 1090                 1095             


Ile Lys  Pro Ile Ser Ser Ile  Phe Gln Lys Ile Thr  Glu Asn Asn 
    1100                 1105                 1110             


Ser Thr  Lys Gln Gln Lys Glu  Lys Ala Ile Tyr Tyr  Thr Gly Lys 
    1115                 1120                 1125             


Ser Glu  Ser Phe Ser Asp Leu  Ile Gly Cys Phe Leu  Lys Tyr Lys 
    1130                 1135                 1140             


Lys 
    


<210>  611
<211>  1103
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  611

Met Lys Ile Ser Lys Ile Tyr Gly Tyr Ser Phe Leu Arg Asn Asp Glu 
1               5                   10                  15      


Lys Gly Tyr Ile Ile Gln Asn Lys Lys Asp Glu Asp Arg Thr Ala Val 
            20                  25                  30          


Tyr Leu Glu Ser Ser Asn Pro Ser Lys Lys Tyr Glu Asp Ser Asn Lys 
        35                  40                  45              


Glu Thr Leu Glu Arg Ile Lys Val Ser Tyr Ile Asn Lys Ile Phe Lys 
    50                  55                  60                  


Asn Ser Lys Gly Tyr Asp Phe Lys Asn Asp Lys Ile Gln Thr Asp Lys 
65                  70                  75                  80  


Asp Lys Ile Tyr His Ala Leu Val Glu Leu Ile Tyr Lys Glu Asn Ile 
                85                  90                  95      


Asp Asp Thr Ile Lys Ile Leu Gln Gly Val Lys Val Asp Asn Leu Gly 
            100                 105                 110         


Lys Asn Leu Ser Asn Asp Ser Lys Arg Ile Tyr Thr Lys Tyr Ile Val 
        115                 120                 125             


Asn Asp Lys Glu Arg Lys Leu Thr Leu Gln Asp Ala Phe Glu Ser Val 
    130                 135                 140                 


Ile Asn Asn Asn Pro Asn Ala Lys Asp Asn Leu Thr Lys Ile Leu Glu 
145                 150                 155                 160 


Val Leu Lys Asn Lys Ile Glu Lys Arg Lys Ala Asp Ile Lys Lys Ser 
                165                 170                 175     


Ile Glu Asn Asn Lys Thr Pro Phe Ile Val Asp Ser Gly Asn Arg Ile 
            180                 185                 190         


Val Tyr Gln Ser Lys Lys Gly Asn Leu Ile Asn Gln Leu Lys Lys Asp 
        195                 200                 205             


Met Ile Lys Asn Gly Tyr Ser Asn Phe Val Lys Glu Ile Glu Glu Val 
    210                 215                 220                 


Glu Lys Lys Val Asn Leu Glu Lys Phe Ile Glu Lys Phe Tyr Gln Asn 
225                 230                 235                 240 


Asp Phe Asp Lys Ile Lys Tyr Leu Ser Glu Phe Arg Asn Asn Phe Tyr 
                245                 250                 255     


Cys Tyr Lys Lys Glu Leu Met Lys Asp Ser Ser Ile Ser Lys Asp Glu 
            260                 265                 270         


Ile Asn Asp Lys Val Tyr Leu Leu Asp Leu Tyr Leu Leu Thr Val Glu 
        275                 280                 285             


Glu Tyr Phe Lys Arg Ile Leu Lys Thr Tyr Asn Gln Lys Arg Asn Ile 
    290                 295                 300                 


Asn Thr Asp Ile Ile Lys Lys Asn Val Val Gly Lys Ile Lys Asn Ala 
305                 310                 315                 320 


Leu Thr Gln Gln Met Ile Asn Glu Gly Lys Ile Ile Lys Tyr Phe Asn 
                325                 330                 335     


Gly Ile Asp Val Thr Lys Tyr His Asp Gly Asp Thr Thr Asn Cys Gln 
            340                 345                 350         


Ile Gly Trp Ile Lys Lys Glu Phe Asn Ser Ser Asp Leu Ile Glu Ile 
        355                 360                 365             


Asn Asn Asn Glu Thr Thr Asn Arg Lys Ile Ile Glu Ala Cys Val Phe 
    370                 375                 380                 


Ala Thr Asn Asn Leu Ala Asn Ile Met Asn Leu Pro Asn Phe Val Asp 
385                 390                 395                 400 


Ile Leu Leu Lys Ser Asn Leu Lys Glu Gln Ile Thr Ser Ser Asn Phe 
                405                 410                 415     


Glu Ile Glu Asn Arg Arg Leu Ala Lys Leu Phe Phe Asp Ile Asp Phe 
            420                 425                 430         


Leu Lys Met Thr Asp Asp Glu Tyr Lys Asp Phe Leu Trp Ala Val Arg 
        435                 440                 445             


Gly Ser Ile Gln Ser Ile Arg Asn Gln Ala Tyr His Asn Thr Lys Asn 
    450                 455                 460                 


Ala Ser Asn Ile Ile Phe Asn Val Gln Asp Tyr Glu Ile Glu Asp Lys 
465                 470                 475                 480 


Thr Thr Lys Lys Phe Tyr Glu Asp Asn Thr Tyr Leu Lys Asn Leu Phe 
                485                 490                 495     


Lys Gln Glu Ile Lys Thr Phe Lys Leu Ala Ile Ile Glu Lys Phe Lys 
            500                 505                 510         


Gly Met Lys Leu Phe Asp Tyr Phe Thr Ile Glu Phe Leu Asn Ser Ile 
        515                 520                 525             


Phe Lys Asn Met Thr Ile Asn Pro Phe Asp Leu Gln Lys Asn Leu Pro 
    530                 535                 540                 


Ser Phe Asn Lys Met Ile Glu Arg Gly Gln Asn Ile Ile Pro Gln Ser 
545                 550                 555                 560 


Phe Leu Lys Met Thr Asp Tyr Asp Val Phe Ser Lys Asn Asp Asp Lys 
                565                 570                 575     


Asp Leu Ala Ile Thr Asn Leu His Lys Val Leu Tyr Glu Tyr Asp Phe 
            580                 585                 590         


Lys His Tyr Phe Leu Ser Asn Ala Thr Leu Phe Lys Thr Ala Val Ser 
        595                 600                 605             


Lys Ala Ile Glu Arg Lys Lys Lys Asp Ile Gln Asn Ile Ser Lys Ile 
    610                 615                 620                 


Asn Leu Glu Val Leu Lys Glu Phe Ser Gly Glu Asn Ala Glu Asp Ile 
625                 630                 635                 640 


Gln Asn Tyr Leu Ala Asp Leu Gln Ser Ala Ile Met Leu Lys Ser Leu 
                645                 650                 655     


Asp Ile Lys Asp Asn Lys Thr Asn Ala Tyr Tyr Leu Phe Leu Leu Asp 
            660                 665                 670         


Ile Thr Ser Phe Gly Phe Asp Asn Tyr Ile Lys Asn Asn Phe Lys Asn 
        675                 680                 685             


Phe Asp Leu Thr Asn Ala Thr Gln Gln Thr Thr Val Gln Thr Glu Ser 
    690                 695                 700                 


Thr Phe Glu Ile Lys Val Ala Asp Leu Lys Ile Asp Ile Thr Asn Glu 
705                 710                 715                 720 


Asn Ile Ala Phe Phe Thr Phe Ala Lys Leu Leu Asn Asn Asp Ile Leu 
                725                 730                 735     


Asn Glu Leu Gln Gln Lys Leu Ile Lys Phe Gln Gln Asn Asn Glu Phe 
            740                 745                 750         


Gln Asn Gln Ile Lys Ile Leu Glu Val Cys Lys Leu Lys Asn Asp Asn 
        755                 760                 765             


Leu Asn Gln Glu Asp Phe Asn Pro Thr Asp Tyr Gly Tyr Glu Glu Ile 
    770                 775                 780                 


Leu Lys Thr Phe Val Ser Asn Asp Val Leu Glu Asn Lys Cys Leu Pro 
785                 790                 795                 800 


Tyr Tyr Asp Asp Lys Asn Pro Ile Ile Phe Lys Glu Ile Tyr Leu Leu 
                805                 810                 815     


Ile Lys Tyr Gly Thr Leu Arg Lys Ile Ser Thr Ile Phe Lys Glu Thr 
            820                 825                 830         


Asp Lys Val Thr Ser Lys Asp Leu Gln Asp Leu Glu Ser Ala Glu Lys 
        835                 840                 845             


Ser Ile Val Gln Asp Ile Lys Asn Arg Asp Lys Leu His Asn Tyr Ile 
    850                 855                 860                 


Ile Glu Asn Ser Asn Asn Leu Glu Ile Asn Thr Leu Asp Ser Tyr Ile 
865                 870                 875                 880 


Tyr Phe Ile Glu Lys Val Asn Asp Phe Val Asn Leu Lys Asn Lys Val 
                885                 890                 895     


Tyr Leu Thr Gln Ile Tyr Lys Met His Thr Ile Leu Cys Lys Val Leu 
            900                 905                 910         


Ala Lys Pro Ile Asn Phe Val Gly Leu Trp Asp Lys Asn Phe Val Asn 
        915                 920                 925             


Ile Val Tyr Ser Tyr Cys Tyr Glu Trp Ile Met Thr Glu Ser Glu Lys 
    930                 935                 940                 


Gly Leu Phe Tyr Glu Phe Val Asp Ala Met Asn Arg Gly Thr Gln Asn 
945                 950                 955                 960 


Phe Lys Asn Ser Ala Asp Lys Leu Pro Thr Asn Ile Asp Val Arg Glu 
                965                 970                 975     


Phe Phe Glu His Ile Tyr Leu His Lys Lys Asp Asp Asn Asp Asn Trp 
            980                 985                 990         


Arg Asn Ile Arg Asn Lys Tyr Ala  His Leu Asp Ile Leu  Lys Asn Gly 
        995                 1000                 1005             


Gln Val  Ile Asp Leu Lys Glu  Ile Val Thr Asp Leu  Arg Lys Leu 
    1010                 1015                 1020             


Phe Thr  Tyr Asp Arg Asn Ser  Lys Asn Lys Ile Thr  Arg Ser Phe 
    1025                 1030                 1035             


Lys His  Leu Leu Glu Arg Asn  Asn Leu Asp Leu Asp  Phe Glu Phe 
    1040                 1045                 1050             


Asn Asn  Asp Asn Thr Phe Lys  Leu Ser Leu Ser Ser  Lys Lys Ile 
    1055                 1060                 1065             


Leu Tyr  Phe Lys Asn Cys Lys  Ile Pro Lys Leu Asp  Asp Lys Lys 
    1070                 1075                 1080             


Thr Thr  Asp Phe Tyr Ser Lys  Asp Tyr Val Lys Lys  Ile Lys Thr 
    1085                 1090                 1095             


Leu Leu  Asn Ile Asp 
    1100             


<210>  612
<211>  1357
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  612

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Pro Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Lys Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Asp Ile Gln Lys Ile Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Lys Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Cys Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Thr Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Phe 
                325                 330                 335     


Asn Gly Leu Glu Glu Leu Glu Asn Leu Ser Gln Gln Lys Lys Glu Lys 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Arg Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Cys Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Lys 
                405                 410                 415     


Arg Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Ala Leu Glu Gly Glu Ser 
    450                 455                 460                 


Val Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Glu Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Ala Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Leu Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Arg Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Lys Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Lys Gly Asp Lys Glu Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Glu Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Ser Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Lys Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Ala Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Val Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Glu Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Met Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Val Leu Val Pro Ala  Arg Ser Glu 
    1325                 1330                 1335             


Val Phe  Leu Lys Gln Phe Arg  Lys Ile Leu Glu Tyr  Arg Ile Gln 
    1340                 1345                 1350             


Asp Lys  Thr Gln 
    1355         


<210>  613
<211>  1140
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  613

Met Arg Gly Asp Tyr Met Lys Ile Thr Lys Ile Asp Gly Ile Ser His 
1               5                   10                  15      


Lys Lys Tyr Lys Glu Lys Gly Lys Leu Ile Lys Ser Asn Glu Ile Glu 
            20                  25                  30          


Lys Asp Val Thr Glu Glu Arg Phe Asn Asp Ile Glu Val Lys Thr Thr 
        35                  40                  45              


Glu Leu Phe Gln Lys Thr Leu Asp Phe Tyr Val Lys Asn Tyr Glu Lys 
    50                  55                  60                  


Cys Glu Glu Gln Asn Lys Glu Arg Arg Glu Lys Ala Lys Asn Tyr Phe 
65                  70                  75                  80  


Ser Lys Val Lys Leu Ile Val Asp Asn Lys Lys Ile Thr Ile Phe Asn 
                85                  90                  95      


Glu Asn Thr Glu Lys Ile Glu Ile Glu Gly Phe Asn Glu Tyr Asp Val 
            100                 105                 110         


Arg Asp Glu Lys Tyr Phe Asn Val Leu Asn Lys Ile Leu Lys Glu Glu 
        115                 120                 125             


Asn Cys Thr Glu Glu Asp Leu Glu Val Phe Glu Asn Asp Leu Gln Lys 
    130                 135                 140                 


Lys Leu Asn Gln Ile Gln Ser Ile Lys Asn Ser Leu Glu Glu Asn Lys 
145                 150                 155                 160 


Ala His Phe Lys Lys Glu Ser Val Asn Asn Thr Ala Asp Arg Val Lys 
                165                 170                 175     


Gly Asn Asn Lys Lys Ser Leu Phe Tyr Glu Tyr Tyr Arg Asn Ser Ser 
            180                 185                 190         


Lys His Gln Glu Tyr Val Asn Asn Ile Phe Glu Ala Phe Asp Lys Leu 
        195                 200                 205             


Tyr Ser Asn Ser His Glu Asp Met Asn Asn Leu Phe Ser Ala Ile Thr 
    210                 215                 220                 


Lys Asp Ser Asn Asp Arg Asn Ile Lys Lys Ile Arg Glu Ala Tyr His 
225                 230                 235                 240 


Glu Ile Leu Asn Lys Asn Lys Ile Glu Phe Gly Glu Glu Leu Tyr Lys 
                245                 250                 255     


Lys Ile Gln Asp Asn Ile Asn Asn Phe Asp Lys Leu Leu Glu Ile Glu 
            260                 265                 270         


Pro Glu Ile Lys Glu Leu Thr Lys Ser Gln Ile Phe Tyr Lys Tyr Tyr 
        275                 280                 285             


Ile Asp Lys Val Ser Leu Asp Gly Thr Asn Ile Lys His Cys Phe Ser 
    290                 295                 300                 


His Leu Val Glu Ile Glu Val Asn Gln Leu Leu Lys Asn Tyr Val Tyr 
305                 310                 315                 320 


Ser Lys Arg Ser Thr Asn Lys Glu Lys Leu Glu Asn Ile Phe Glu Tyr 
                325                 330                 335     


Cys Lys Leu Lys Asn Leu Val Lys Asn Lys Leu Val Asn Lys Leu Asn 
            340                 345                 350         


Ser Tyr Ile Arg Asn Cys Gly Lys Tyr Asn Ser Tyr Ile Asn Asn Asn 
        355                 360                 365             


Asp Val Val Asn Ser Glu Lys Ile Ser Glu Ile Arg Thr Lys Glu Ala 
    370                 375                 380                 


Phe Leu Arg Ser Ile Ile Gly Val Ser Ser Ser Ala Tyr Phe Ser Leu 
385                 390                 395                 400 


Arg Asn Ile Leu Asn Thr Asp Asn Thr Gln Asp Ile Thr Asn Lys Val 
                405                 410                 415     


Lys Gly Glu Val Glu Lys Leu Tyr Gln Glu Asn Lys Lys Val Lys Leu 
            420                 425                 430         


Glu Glu Arg Leu Lys Leu Phe Phe Gly Asn Asn Phe Asp Ile Asn Asn 
        435                 440                 445             


Gln Gln Glu Ile Glu Asp Phe Leu Met Asn Ile Asp Lys Ile Ile Ser 
    450                 455                 460                 


Asn Ile Arg His Glu Ile Ile His Phe Lys Ile Glu Ala Asn Ala His 
465                 470                 475                 480 


Ser Ile Phe Asp Phe Asn Asn Val Thr Leu Gly Asn Lys Ala Lys Asn 
                485                 490                 495     


Ile Phe Asn Asn Glu Ile Asn Glu Glu Arg Ile Lys Phe Lys Ile Phe 
            500                 505                 510         


Lys Gln Leu Asn Ser Ala Asn Val Phe Asp Tyr Leu Ser Asp Glu Asn 
        515                 520                 525             


Ile Thr Glu Tyr Met Gly Lys Val Ile Phe Ser Phe Thr Asn Arg Asn 
    530                 535                 540                 


Ile Pro Phe Val Pro Ser Phe Arg Lys Ile Tyr Asn Arg Val Gln Asp 
545                 550                 555                 560 


Leu Ala Asn Ser Leu Lys Ile Lys Glu Trp Lys Ile Ser Asp Glu Ser 
                565                 570                 575     


Glu Gly Lys Asp Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Glu 
            580                 585                 590         


Glu Phe Leu Asp Glu Phe Leu Asn Glu Glu Asn Gly Ile Phe Ile Ser 
        595                 600                 605             


Ile Lys Asp Lys Ile Ile Glu Leu Asn Arg Asn Gln Asn Lys Arg Thr 
    610                 615                 620                 


Gly Phe Tyr Lys Leu Glu Lys Phe Glu Lys Ile Glu Glu Lys Asn Pro 
625                 630                 635                 640 


Lys Lys Tyr Leu Glu Ile Ile Gln Ser Leu Tyr Met Ile Asn Ile Glu 
                645                 650                 655     


Glu Ile Asp Asn Glu Glu Lys Asn Ile Phe Leu Asp Phe Ile Gln Lys 
            660                 665                 670         


Ile Phe Leu Lys Gly Phe Phe Glu Phe Ile Lys Asn Asn Tyr Asn Tyr 
        675                 680                 685             


Leu Leu Glu Leu Lys Lys Ile Gln Asp Lys Lys Asn Ile Phe Asp Ser 
    690                 695                 700                 


Glu Met Ser Glu Tyr Ile Ala Gly Glu Lys Thr Leu Glu Asp Val Gly 
705                 710                 715                 720 


Glu Ile Asn Glu Ile Ile Gln Lys Ile Glu Ile Met Lys Ile Asp Lys 
                725                 730                 735     


Ile Leu Asn Leu Thr Asp Lys Ile Asn Cys Phe Tyr Leu Leu Leu Lys 
            740                 745                 750         


Leu Leu Asn Tyr Lys Glu Ile Thr Glu Leu Lys Gly Asn Leu Glu Lys 
        755                 760                 765             


Tyr Gln Ile Leu Ser Lys Thr Asp Ile Tyr Glu Lys Glu Leu Ile Leu 
    770                 775                 780                 


Leu Asn Ile Val Asn Leu Asp Asn Asn Lys Val Lys Ile Glu Lys Phe 
785                 790                 795                 800 


Lys Ile Ser Ala Glu Glu Ile Gly Lys Phe Ile Glu Lys Ile Ser Arg 
                805                 810                 815     


Asn Lys Lys Ile Lys Thr Phe Glu Glu Leu Arg Asn Phe Glu Lys Arg 
            820                 825                 830         


Glu Asn Thr Gly Glu Tyr Tyr Asn Val Tyr Ser Asp Asp Lys Asn Ile 
        835                 840                 845             


Lys Asn Ile Arg Asn Leu Tyr Asn Ile Lys Lys Tyr Gly Met Leu Asp 
    850                 855                 860                 


Leu Leu Glu Arg Ile Ser Glu Lys Ser Asn Tyr Cys Ile Lys Lys Glu 
865                 870                 875                 880 


Asp Leu Glu Glu Tyr Ser Glu Leu Arg Lys Gln Leu Glu Asp Glu Lys 
                885                 890                 895     


Thr Asn Phe Tyr Lys Ile Gln Lys Asp Leu His Tyr Glu Tyr Gln Lys 
            900                 905                 910         


Lys Tyr Lys Asn Phe Ser Lys Lys Asn Asn Pro Glu Asp Tyr Glu Lys 
        915                 920                 925             


Tyr Lys Glu Ser Ile Lys Asn Ile Glu Lys Tyr Val His Leu Lys Asn 
    930                 935                 940                 


Lys Ile Glu Phe Asn Glu Leu Asn Leu Leu Gln Ser Leu Leu Leu Lys 
945                 950                 955                 960 


Ile Leu His Arg Leu Val Gly Phe Thr Ser Ile Trp Glu Arg Asp Leu 
                965                 970                 975     


Arg Phe Arg Leu Ile Gly Glu Phe Pro Asp Glu Leu Asp Val Glu Asp 
            980                 985                 990         


Ile Phe Asp His Arg Glu Arg Tyr  Arg Gly Thr Arg Gly  Gln Ile Cys 
        995                 1000                 1005             


Lys Lys  Tyr Asp Gln Phe Ile  Ser Val His Ile Glu  Tyr Gln Asn 
    1010                 1015                 1020             


Asn Asn  Lys Met Lys Asn Ile  Lys Phe Asp Asp Asn  Asn Pro Ile 
    1025                 1030                 1035             


Arg Asn  Tyr Ile Ala His Phe  Asn Tyr Leu Pro Thr  Pro Lys Tyr 
    1040                 1045                 1050             


Ser Ile  Leu Lys Met Leu Gly  Lys Leu Arg Glu Leu  Leu Asp Tyr 
    1055                 1060                 1065             


Asp Arg  Lys Leu Lys Asn Ala  Val Met Lys Ser Ile  Lys Asp Ile 
    1070                 1075                 1080             


Leu Glu  Glu Tyr Gly Phe Lys  Ala Glu Phe Val Ile  Asn Pro Asp 
    1085                 1090                 1095             


Lys Glu  Ile Ile Leu Asn Ser  Val Lys Ser Val Glu  Ile Ile His 
    1100                 1105                 1110             


Leu Lys  Lys Asn Asp Leu Asn  Ser His Arg Asn Ser  Glu Asp Leu 
    1115                 1120                 1125             


Cys Lys  Leu Val Lys Ala Met  Leu Glu Tyr Ser Glu  
    1130                 1135                 1140 


<210>  614
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  614

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  615
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  615

Met Lys Ile Thr Lys Ile Asp Gly Ile Ser His Lys Lys Tyr Ile Lys 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Lys Thr Asp Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Thr Ile Arg Leu Asp Thr Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Glu Phe Phe Ser Asn Lys Val Leu Tyr Leu Lys Asp Gly Ile Leu 
65                  70                  75                  80  


Tyr Leu Lys Asp Arg Arg Glu Lys Asn Gln Leu Gln Asn Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Leu Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Asn Asp Phe Glu Lys Lys Leu Asp Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Leu Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Ile Lys Lys Val Glu Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Phe Tyr Asn Tyr Tyr Lys Asp Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Ile Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Asn Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys Tyr Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Thr Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Met 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asn Val Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asn Lys Glu Lys Leu Asn Asp Glu 
        275                 280                 285             


Asn Ile Lys Tyr Val Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Ser Phe Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Val Gly Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Thr Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Ile Lys Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Ile Ser Gly Glu Ile Asp Lys Leu Tyr Asp 
            420                 425                 430         


Asn Asn Lys Gln Asn Glu Val Lys Lys Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asn Ser Lys Lys Glu Ile Glu Asp Phe Phe Ser 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Thr Phe Lys Asn Ile Val 
                485                 490                 495     


Pro Ser Gln Ile Ser Lys Lys Met Phe His Asp Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Lys Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Asn Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Cys Ile Tyr Trp 
                565                 570                 575     


Lys Ile Pro Lys Ala Asn Asp Asn Asn Lys Thr Lys Glu Ile Thr Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ile Lys Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asn Leu Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Met Gln Ser Phe Tyr Met Ile Asp Ala Gly Asn Lys Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Ala Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Met 
    690                 695                 700                 


Tyr Ile Gly Asn Asp Glu Gln Ile Asn Thr Ser Leu Ala Gly Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Lys Ile Leu Lys Tyr Thr Glu Ser Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Phe Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Val Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Asn Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Lys 
        915                 920                 925             


Lys Tyr Glu Lys Ala Ile Arg Asn Ile Gln Gln Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Ser Leu Leu Leu 
945                 950                 955                 960 


Arg Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Asn Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asp  Thr Glu Lys Ile Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Glu Leu  Lys Lys Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  Asn Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Met Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Ile Met Lys Ser  Ile Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Val Thr Phe Lys  Ile Glu Lys Asp Lys  Lys Ile Arg 
    1100                 1105                 1110             


Ile Glu  Ser Leu Lys Ser Glu  Glu Val Val His Leu  Lys Lys Leu 
    1115                 1120                 1125             


Lys Leu  Lys Asp Asn Asp Lys  Lys Lys Glu Pro Ile  Lys Thr Tyr 
    1130                 1135                 1140             


Arg Asn  Ser Lys Glu Leu Cys  Lys Leu Val Lys Val  Met Phe Glu 
    1145                 1150                 1155             


Tyr Lys  Met Lys Glu Lys Lys  Ser Glu Asn 
    1160                 1165             


<210>  616
<211>  1172
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  616

Met Lys Val Thr Lys Ile Asp Gly Leu Ser His Lys Lys Phe Glu Arg 
1               5                   10                  15      


Leu Glu Lys Leu Lys Glu Ile Lys Leu Gly Asn Tyr Ile Lys Asn Pro 
            20                  25                  30          


Asp Lys Thr Lys Asp Lys Asp Asn Lys Lys Arg Arg Lys Glu Leu Lys 
        35                  40                  45              


Glu Tyr Phe Ser Glu Ile Thr Leu Arg Lys Glu Asn Gly Lys Tyr Val 
    50                  55                  60                  


Leu Leu Lys Ser Lys Lys Leu Lys Lys Ile Asn Asn Asn Ile Lys Asp 
65                  70                  75                  80  


Thr Asp Ile Lys Val Lys His Lys Lys Glu Glu Val Phe Asp Val Leu 
                85                  90                  95      


Lys Glu Ile Leu Gln Leu Asn Leu Leu Ala Asn Asp Val Glu Glu Lys 
            100                 105                 110         


Ile Gln Phe Asp Ser Ile Lys Leu Lys Asn Val Phe Gly Lys Asp Phe 
        115                 120                 125             


Val Lys Lys Glu Leu Gln Ile Lys Ser Ile Glu Glu Ser Leu Glu Lys 
    130                 135                 140                 


Asn Lys Ala Asp Tyr Arg Lys Glu Phe Ile Glu Thr Glu Asn Asn Lys 
145                 150                 155                 160 


Tyr Gly Asn Val Lys Gly Glu Asn Lys Lys Asn Cys Ile Tyr Glu Tyr 
                165                 170                 175     


Tyr Lys Lys Ser Lys Thr His Glu Lys Phe Arg Lys Asn Ile Thr Glu 
            180                 185                 190         


Ala Phe Glu Lys Leu Tyr Thr Glu Glu Asn Ile Lys Glu Leu Tyr Ser 
        195                 200                 205             


Lys Ile Glu Glu Val Leu Lys Lys Thr His Leu Lys Ser Ile Val Arg 
    210                 215                 220                 


Glu Phe Tyr Gln Asn Glu Ile Ile Gly Glu Ser Glu Phe Ser Glu Lys 
225                 230                 235                 240 


Gly Glu Asp Gly Ile Ser Ile Leu Tyr Asn Gln Ile Ile Arg Ser Asn 
                245                 250                 255     


Glu Lys Lys Glu Lys Phe Val Lys Phe Leu Glu Asn Ile Glu Asn Leu 
            260                 265                 270         


Gln Leu Lys Glu Leu Thr Lys Ser Gln Ile Phe Tyr Lys Tyr Phe Leu 
        275                 280                 285             


Glu Asn Glu Glu Leu Asp Asp Glu Asn Ile Lys Asn Val Phe Cys Tyr 
    290                 295                 300                 


Phe Val Glu Ile Glu Val Asn Asp Leu Leu Lys Gly Asn Val Tyr Arg 
305                 310                 315                 320 


Val Ser Lys Ile Tyr Glu Asn Lys Ile Lys Asn Ile Phe Glu Tyr Asn 
                325                 330                 335     


Lys Leu Lys Lys Leu Val Val Asn Lys Leu Lys Asn Lys Leu Asn Asn 
            340                 345                 350         


Tyr Val Arg Asn Cys Gly Lys Tyr Asn Tyr His Met Glu Asn Gly Asp 
        355                 360                 365             


Ile Ala Thr Ser Asp Ile Asn Met Arg Asn Arg Gln Thr Glu Ala Phe 
    370                 375                 380                 


Leu Arg Ser Met Ile Gly Val Ser Ser Phe Gly Tyr Phe Ser Leu Arg 
385                 390                 395                 400 


Asn Ile Leu Gly Val Asn Asp Asp Asp Phe Tyr Glu Ile Glu Glu Asp 
                405                 410                 415     


Leu Thr Glu Asp Glu Arg Lys Asn Glu Ser Asn Val Leu Lys Lys Ala 
            420                 425                 430         


Lys Glu Asp Ile Thr Ser Lys Ser Ile Phe Glu Lys Val Val Asp Lys 
        435                 440                 445             


Ser Phe Glu Lys Lys Gly Ile His Ser Ile Arg Glu Asn Val Lys Met 
    450                 455                 460                 


Phe Tyr Gly Val Ser Phe Asp Lys Ala Asn Glu Asp Glu Leu Lys Gln 
465                 470                 475                 480 


Phe Phe Val Asn Met Leu Asn Ala Ile Thr Ser Ile Arg His Arg Val 
                485                 490                 495     


Val His Tyr Asn Met Asn Thr Asn Ser Glu Asn Ile Phe Asn Phe Ser 
            500                 505                 510         


Asp Ile Glu Val Ser Arg Leu Leu Lys Asn Ile Phe Glu Lys Glu Thr 
        515                 520                 525             


Asp Lys Arg Glu Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala 
    530                 535                 540                 


Gly Val Phe Asp Tyr Trp Glu Asp Trp Lys Ile Glu Lys Tyr Leu Lys 
545                 550                 555                 560 


Asn Ile Glu Phe Lys Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser 
                565                 570                 575     


Phe Thr Lys Leu Tyr Asn Arg Ile Asp Asn Leu Lys Gly Ser Asn Ala 
            580                 585                 590         


Leu Asn Leu Gly Phe Ile Asn Ile Pro Lys Arg Lys Glu Ala Arg Asp 
        595                 600                 605             


Ser Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Val Glu 
    610                 615                 620                 


Lys Phe Val Asn Asn Asn Asp Asn Phe Glu Lys Ile Phe Arg Glu Ile 
625                 630                 635                 640 


Ile Glu Ile Asn Lys Asn Ala Gly Thr Asn Thr Lys Thr Lys Phe Tyr 
                645                 650                 655     


Lys Leu Glu Lys Phe Glu Thr Leu Lys Ala Asn Thr Pro Thr Glu Tyr 
            660                 665                 670         


Leu Glu Lys Leu Gln Ser Leu His Gln Ile Asn Tyr Asp Lys Glu Lys 
        675                 680                 685             


Ile Glu Glu Asp Lys Asp Val Tyr Val Asp Phe Val Gln Lys Ile Phe 
    690                 695                 700                 


Leu Lys Gly Phe Ile Asn Tyr Leu Gln Lys Ser Asn Ser Leu Lys Leu 
705                 710                 715                 720 


Leu Asn Leu Leu Asn Leu Lys Lys Asp Glu Val Ile Asn Ser Glu Lys 
                725                 730                 735     


Ser Ser Tyr Asp Glu Lys Leu Lys Gln Trp Glu Asn Asn Gly Ser Lys 
            740                 745                 750         


Leu Ser Glu Met Pro Lys Glu Ile Tyr Arg Tyr Ile Lys Glu Ile Asn 
        755                 760                 765             


Ile Asn Lys Thr Asn Tyr Ser Asp Arg Met Ser Ile Phe Tyr Leu Leu 
    770                 775                 780                 


Leu Lys Leu Ile Asp His Lys Glu Leu Thr Asn Leu Arg Gly Asn Leu 
785                 790                 795                 800 


Glu Lys Tyr Glu Ser Met Asn Lys Asn Lys Ile Tyr Ser Glu Glu Leu 
                805                 810                 815     


Asn Ile Val Asn Leu Val Ser Leu Asp Asn Asn Lys Val Arg Thr Asn 
            820                 825                 830         


Phe Ser Val Glu Ala Glu Asp Ile Gly Lys Phe Leu Lys Thr Glu Thr 
        835                 840                 845             


Ser Ile Lys Asn Ile Asn Gln Leu Asn Asn Phe Ser Gly Ile Phe Ala 
    850                 855                 860                 


Asp Gly Glu Asn Val Ile Lys His Arg Ser Phe Tyr Asn Ile Lys Lys 
865                 870                 875                 880 


Tyr Gly Ile Leu Asp Leu Leu Glu Lys Ile Val Ala Lys Ala Asp Leu 
                885                 890                 895     


Lys Ile Thr Lys Glu Glu Ile Lys Lys Tyr Glu Asn Leu Gln Asn Glu 
            900                 905                 910         


Leu Lys Arg Asn Asp Phe Tyr Lys Ile Gln Glu Lys Ile His Arg Lys 
        915                 920                 925             


Tyr Asn Gln Lys Pro Asn Leu Ile Ser Arg Thr Glu Asn Lys Lys Asp 
    930                 935                 940                 


Phe Asn Asp Tyr Lys Lys Ala Ile Glu Asn Ile Gln Asn Tyr Thr Gln 
945                 950                 955                 960 


Leu Lys Asn Lys Ile Glu Phe Asn Asp Leu Asn Leu Leu Gln Ser Leu 
                965                 970                 975     


Leu Phe Arg Ile Leu His Arg Leu Ala Gly Tyr Thr Ser Leu Trp Glu 
            980                 985                 990         


Arg Asp Leu Gln Phe Lys Leu Lys  Gly Glu Phe Pro Glu  Asp Lys Tyr 
        995                 1000                 1005             


Ile Asp  Glu Ile Phe Asn Ser  Asp Gly Asn Asn Asn  Gln Lys Tyr 
    1010                 1015                 1020             


Lys Asn  Gly Gly Ile Ala Asp  Lys Tyr Ala Asp Phe  Leu Ile Glu 
    1025                 1030                 1035             


Lys Glu  Glu Glu Lys Ser Gly  Glu Ile Leu Lys Lys  Asn Gln Arg 
    1040                 1045                 1050             


Asn Lys  Arg Lys Lys Lys Ile  Lys Glu Asp Leu Glu  Ile Arg Asn 
    1055                 1060                 1065             


Tyr Ile  Ala His Phe Asn Tyr  Phe Pro Asp Ala Thr  Lys Ser Ile 
    1070                 1075                 1080             


Leu Glu  Leu Leu Glu Glu Leu  Arg Glu Leu Leu Lys  Tyr Asp Arg 
    1085                 1090                 1095             


Lys Leu  Lys Asn Ala Val Met  Lys Ser Val Lys Asp  Ile Phe Lys 
    1100                 1105                 1110             


Glu Tyr  Gly Phe Ile Val Glu  Phe Gly Ile Ser His  Glu Ser Asn 
    1115                 1120                 1125             


Ser Lys  Lys Ile Lys Val Cys  Asp Val Lys Ser Glu  Glu Ile Lys 
    1130                 1135                 1140             


His Leu  Lys Asn Asn Gly Leu  Val Thr Thr Arg Asn  Ser Glu Asp 
    1145                 1150                 1155             


Leu Cys  Glu Leu Val Lys Val  Met Leu Glu Tyr Lys  Lys Ser 
    1160                 1165                 1170         


<210>  617
<211>  1150
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  617

Met Gly Asn Leu Phe Gly His Lys Arg Trp Tyr Lys Val Asp Lys Thr 
1               5                   10                  15      


Ile Glu Lys Asp Gly Lys Thr Asn Thr Ile Lys Lys Glu Val Arg Ile 
            20                  25                  30          


Lys Arg Asn Tyr Leu Thr Asp Arg Tyr Ile Leu Asn Thr Asn Asn Lys 
        35                  40                  45              


Asp Lys Asn Asn Ile Asn Asn Glu Asp Phe Val Asn Gln Phe Ile Glu 
    50                  55                  60                  


Tyr Lys Thr Asn Asn Asp Ile Phe Lys Lys Phe Thr Arg Lys Phe His 
65                  70                  75                  80  


Met Gly Asn Ile Leu Phe Lys Leu Lys Ala Lys Glu Ser Lys Asn Lys 
                85                  90                  95      


Ala Val Leu Glu Ile Arg Asn Tyr Ser His Phe Leu Glu Thr Glu Lys 
            100                 105                 110         


Ala Val Leu Glu Ile Glu Ile Tyr Gln Gln Ser Glu Lys Leu Ile Glu 
        115                 120                 125             


Glu Glu Asn Ile Thr Lys Lys Asp Ile Ile Asp Lys Ala Ile Lys Glu 
    130                 135                 140                 


Lys Ile Thr Glu Asp Ser Asn Glu Ile Lys Met Gln Val Lys Leu Lys 
145                 150                 155                 160 


Glu Asn Lys Ser Lys Glu Ile Lys Ile Ser Ile Asn Lys Glu Thr Glu 
                165                 170                 175     


Glu Tyr His Ile Lys Leu Lys Ser Ile Asn Asn Asp Glu Leu Asn Leu 
            180                 185                 190         


Lys Arg Glu Ile Tyr Glu Ile Leu Lys Ser Ile Asn Ala Asn Leu Tyr 
        195                 200                 205             


Ile Ile Thr Lys Asn Ala Ile Ser Asn Ala Asp Phe Lys Lys Arg Asn 
    210                 215                 220                 


Tyr Glu Thr Phe Leu Lys Lys Ser Met Gly Glu Tyr Leu Arg Lys Asn 
225                 230                 235                 240 


Ile Asn Lys Lys Pro Glu Asn Thr Phe Leu Lys Ser Leu Ser Asn Ser 
                245                 250                 255     


Leu Lys Lys Ile Gln Asn Asn Ile Arg Glu Asn Glu Glu Ile Ile Asn 
            260                 265                 270         


Phe Ile Lys Tyr Tyr Ser Asn Ile Asn Gly Asn Lys Thr Val Ser Glu 
        275                 280                 285             


Ser Lys Lys Thr Phe Leu Glu Lys Ile Leu Asn Ile Glu Val Ser Ile 
    290                 295                 300                 


Ser Glu Asn Asp Ile Ile Asp Phe Ile Ile Gly Glu Leu Lys Phe Tyr 
305                 310                 315                 320 


Gly Ile Ile Lys Arg Ile Glu Lys Leu Gln Lys Glu Gly Asn Arg Thr 
                325                 330                 335     


Lys Thr Glu Ile Glu Asn Thr Tyr Ile Lys Ser Tyr Val Leu Leu Asp 
            340                 345                 350         


Lys His Glu Lys Phe Lys Lys Tyr Asn Arg Asn Lys Lys Asp Glu Ile 
        355                 360                 365             


Val Lys Leu Phe Val Lys Asp Ile His Asn Asn Thr Met Glu Glu Lys 
    370                 375                 380                 


Ile Asn His Ile Leu Ser Lys Phe Lys Ile Lys Glu Leu Thr Glu Lys 
385                 390                 395                 400 


Leu Lys Glu Asn Thr Lys Asn Lys Asn Phe Asp Thr Glu Ile Phe Gly 
                405                 410                 415     


Ile Phe Lys Val His Tyr Gln Glu Met Phe Ser Ser Glu Lys Phe Glu 
            420                 425                 430         


Glu Lys Ser Asp Glu Glu Lys Glu Leu Tyr Lys Ile Ile Tyr Arg Tyr 
        435                 440                 445             


Leu Lys Gly Arg Ile Glu Lys Ile Leu Ile Asn Glu Glu Lys Val Arg 
    450                 455                 460                 


Leu Lys Lys Met Glu Lys Ile Leu Ile Asn Gly Glu Lys Ile Arg Leu 
465                 470                 475                 480 


Asn Lys Ile Glu Lys Ile Glu Ile Glu Lys Ile Leu Asn Glu Ser Ile 
                485                 490                 495     


Leu Ser Glu Lys Ile Leu Lys Arg Val Lys Gln Tyr Thr Leu Glu Tyr 
            500                 505                 510         


Ile Met Tyr Leu Gly Lys Leu Val His Asn Asn Ile Asp Met Thr Thr 
        515                 520                 525             


Val Asn Thr Asn Asp Phe Ser Lys Leu His Ala Lys Glu Glu Leu Asp 
    530                 535                 540                 


Leu Glu Leu Ile Thr Phe Phe Ala Ser Thr Asn Met Glu Leu Asn Lys 
545                 550                 555                 560 


Ile Phe Ser Arg Glu Asn Ile Asn Asn Asp Glu Asn Ile Asp Phe Phe 
                565                 570                 575     


Gly Gly Asp Arg Glu Lys Asn Tyr Val Leu Asp Lys Lys Asn Leu Asn 
            580                 585                 590         


Ser Lys Ile Lys Ile Ile Arg Asp Leu Asp Phe Ile Asp Asn Lys Asn 
        595                 600                 605             


Asn Ile Thr Asn Asp Phe Ile Asn Lys Phe Thr Lys Ile Gly Thr Asn 
    610                 615                 620                 


Glu Arg Asn Arg Ile Leu His Ala Ser Gly Lys Lys Arg Asp Ser Gln 
625                 630                 635                 640 


Gly Thr Gln Asp Asp Tyr Asn Lys Val Ile Asn Ile Ile Gln Asn Leu 
                645                 650                 655     


Lys Ile Ser Asp Glu Glu Val Ser Lys Val Leu Asn Leu Asp Val Val 
            660                 665                 670         


Phe Lys Asp Lys Lys Asn Ile Ile Thr Glu Ile Asn Asp Ile Lys Ile 
        675                 680                 685             


Ser Glu Lys Asn Ser Asn Asp Ile Lys Tyr Leu Pro Ser Phe Ser Lys 
    690                 695                 700                 


Val Leu Pro Glu Ile Leu Asn Leu Tyr Arg Asn Asn Pro Lys Asn Glu 
705                 710                 715                 720 


Pro Phe Asp Thr Val Glu Thr Glu Lys Ile Val Leu Asn Ala Leu Ile 
                725                 730                 735     


Tyr Val Asn Lys Glu Leu Tyr Lys Lys Leu Ile Leu Glu Asp Asp Leu 
            740                 745                 750         


Gln Glu Asn Arg Ser Lys Asn Ile Phe Leu Gln Glu Leu Lys Lys Thr 
        755                 760                 765             


Leu Gly Gly Thr Asp Glu Ile Asp Glu Asn Ile Ile Glu Asn Tyr Tyr 
    770                 775                 780                 


Lys Asn Ala Gln Ile Ser Ala Ser Lys Gly Asn Asn Lys Ala Ile Lys 
785                 790                 795                 800 


Lys Tyr Gln Lys Lys Ile Ile Glu Cys Tyr Ile Glu Tyr Leu Arg Lys 
                805                 810                 815     


Asn Tyr Glu Lys Leu Phe Asp Phe Ser Asp Phe Glu Met Asn Ile Gln 
            820                 825                 830         


Glu Ile Lys Lys Gln Ile Lys Glu Ile Asn Asp Asn Lys Thr Tyr Lys 
        835                 840                 845             


Arg Ile Thr Ile Lys Thr Ser Asp Lys Ser Ile Val Ile Asn Asn Asp 
    850                 855                 860                 


Phe Glu Tyr Ile Ile Ser Ile Phe Ala Leu Leu Asn Asn Asn Ile Val 
865                 870                 875                 880 


Ile Asn Lys Ile Arg Asn Arg Phe Phe Ala Thr Ser Val Trp Leu Asn 
                885                 890                 895     


Thr Ser Glu Tyr Gln Asn Ile Ile Asp Ile Leu Asp Glu Ile Met Gln 
            900                 905                 910         


Ile Asn Ile Leu Lys Ser Glu Tyr Ile Thr Ser Asn Trp Lys Glu Asn 
        915                 920                 925             


Leu Glu Glu Phe Ile Arg Lys Thr Lys Asn Lys Glu Ile Glu Leu His 
    930                 935                 940                 


Gln Ser Lys Lys Glu Phe Phe Asp Asn Asn Tyr Lys Glu Ile Lys Lys 
945                 950                 955                 960 


Asp Met Ile Val Lys Ile Asn Asp Asn Lys Ile Gln Lys Ile Leu Asn 
                965                 970                 975     


Lys Tyr Leu Lys Glu Ile Thr Gly Phe Ser Ser Asn Asn Glu Tyr Met 
            980                 985                 990         


Phe Lys Asn Leu Gly Lys Leu Thr  Leu Glu Glu Arg Asp  Phe Ile Leu 
        995                 1000                 1005             


Ser Asn  Lys Asn Asn Lys Lys  Leu Ile Glu Lys Asn  Ile Asp Glu 
    1010                 1015                 1020             


Ile Ile  Gly Glu Lys Leu Asp  Ala Ile Lys Glu Lys  Ile Leu Leu 
    1025                 1030                 1035             


Arg Lys  Val Phe Ser Ser Lys  Phe Leu Glu Lys Tyr  Lys Lys Glu 
    1040                 1045                 1050             


Ile Asp  Asn Leu Val Glu Ser  Thr Glu Ser Lys Asn  Glu Asn Lys 
    1055                 1060                 1065             


Phe Glu  Lys Ile Tyr Tyr Pro  Lys Glu His Lys Asn  Glu Leu Tyr 
    1070                 1075                 1080             


Ile Tyr  Lys Lys Asn Leu Phe  Leu Asn Ile Gly Asn  Pro Asn Phe 
    1085                 1090                 1095             


Asp Lys  Ile Tyr Gly Leu Ile  Ser Lys Asp Ile Lys  Asn Val Asp 
    1100                 1105                 1110             


Thr Lys  Ile Leu Phe Asp Asp  Asp Ile Arg Lys Asn  Lys Ile Ser 
    1115                 1120                 1125             


Glu Ile  Asp Ala Ile Leu Lys  Asn Leu Asn Asp Lys  Leu Asn Gly 
    1130                 1135                 1140             


Tyr Ser  Asn Asp Tyr Lys Ala  
    1145                 1150 


<210>  618
<211>  1432
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  618

Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser Val Thr 
1               5                   10                  15      


Glu Asn Lys Asn Glu Glu Gln Leu Ser Arg Gln Ser Leu Leu Tyr Tyr 
            20                  25                  30          


Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp Leu Glu 
        35                  40                  45              


Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr Asn Val 
    50                  55                  60                  


Ile Thr Pro Glu Ile Asp Leu Cys Lys Glu Glu Asn Arg Glu Trp Ile 
65                  70                  75                  80  


Val Glu Asp Leu Thr Lys Asn Phe Asn Ala Val Ile Asn Asn Ala Leu 
                85                  90                  95      


Arg Ser Ile Lys Asn Pro Lys Glu Lys Arg Glu Glu Arg Val Glu Lys 
            100                 105                 110         


Glu Val Ala Phe Ile Leu Asn Leu Asn Lys Asn Ser Ile Lys Ile Lys 
        115                 120                 125             


Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe Ser Ala 
    130                 135                 140                 


Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser Lys Glu 
145                 150                 155                 160 


Glu Ala Tyr Ile Arg Glu Met Ile Ser Asn Leu Val Leu Arg Lys Leu 
                165                 170                 175     


Lys Lys Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Cys Lys Met 
            180                 185                 190         


Gln Met Thr Glu Ile Thr Ile Ser Leu Met Ser Ala Ile Cys Leu Tyr 
        195                 200                 205             


Gly Asn Val Glu Ser Phe Asp Pro Val Ile Leu Lys Ala Phe Phe Glu 
    210                 215                 220                 


Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile Val 
225                 230                 235                 240 


Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys Asp 
                245                 250                 255     


Gly Lys His Leu Leu Ile Pro Ala Asn Ala Asp His Arg Lys Lys Lys 
            260                 265                 270         


Tyr Val Phe Glu Phe Met Arg Lys Tyr Ala Ala Ala Glu Glu Lys Glu 
        275                 280                 285             


Lys Arg Glu Ile Thr Glu His Ile Gln Asn Leu Ile Gly Leu Tyr Leu 
    290                 295                 300                 


Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asn Met 
305                 310                 315                 320 


Thr Glu Ser His Asn Cys Ile Ser Gly Glu Ile Glu Glu Ile Phe Asn 
                325                 330                 335     


Glu Ile Glu Glu Leu Glu Asn Ser Ser Lys Gln Lys Arg Glu Glu Lys 
            340                 345                 350         


Lys Lys Thr Arg Glu Glu Leu Asp Lys Ile Gln Glu Ser Arg Lys Gly 
        355                 360                 365             


Asn Lys Arg Asn Thr Asn Ser Asn Asn Gln Asn Tyr Lys Asn Asn Lys 
    370                 375                 380                 


Thr Asp Ser Asp Lys Lys Glu Asn Gln Ala Asp Ala Asn Glu Asn Lys 
385                 390                 395                 400 


Leu Lys Glu Asn Glu Leu Arg Asp Lys Arg Arg Arg Leu Ser Lys Glu 
                405                 410                 415     


Leu Glu Asn Leu Asp Ser Glu Val Arg Ile Lys Lys Glu Lys Leu Lys 
            420                 425                 430         


Asn Thr Thr Val Lys Glu Met Ala Leu Lys Tyr Arg Ala Ala Val Asn 
        435                 440                 445             


Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile Lys Glu 
    450                 455                 460                 


Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr Ile Asp 
465                 470                 475                 480 


Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp Arg Tyr 
                485                 490                 495     


Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu Trp Thr 
            500                 505                 510         


Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val Tyr His 
        515                 520                 525             


Phe Ala Ile Pro Asp Leu Ser Gly Ala Leu Glu Gly Glu Ser Val Ser 
    530                 535                 540                 


Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly Phe Asp 
545                 550                 555                 560 


Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met Glu Lys 
                565                 570                 575     


Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr Pro Glu 
            580                 585                 590         


Glu Glu Arg Glu Lys Pro Gly His Glu Asp Val Leu Leu Met Lys Thr 
        595                 600                 605             


Leu Ser Glu Ile Glu Glu Ser Gln Thr Glu Glu Glu Arg Gln Lys Lys 
    610                 615                 620                 


His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp Ala Asp 
625                 630                 635                 640 


Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg Lys Lys 
                645                 650                 655     


Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr Lys Glu 
            660                 665                 670         


Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His Tyr Thr 
        675                 680                 685             


Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Glu Leu Thr Glu Tyr 
    690                 695                 700                 


Phe Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg Glu Lys 
705                 710                 715                 720 


Tyr Tyr Thr Asn Asn Val Trp Lys Tyr Tyr Asp Ile Glu Val Ile Asn 
                725                 730                 735     


Asn Ile Met Gly Lys Ile Tyr Cys Gly Arg Lys Tyr Arg Ala Ala Gln 
            740                 745                 750         


Val Pro Ala Phe Asn Asn Ile Ile Ser Arg Pro Ala Leu Pro Gln Leu 
        755                 760                 765             


Met Asp Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met Asn Cys 
    770                 775                 780                 


Pro Asp Arg Asp Val Ile Lys Lys Tyr Trp Ser Ser Leu Phe Phe Val 
785                 790                 795                 800 


Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Glu Lys Pro 
                805                 810                 815     


Glu Asp Asn Ile Lys Glu Arg Phe Phe Arg Ala Met Glu Lys Glu Ser 
            820                 825                 830         


Gly Gln Ala Lys Asp Gly Lys Glu Gln Lys Ala Trp Glu Ser Phe Glu 
        835                 840                 845             


Asn Arg Ile Asp Gln Ile Gly Arg Glu Arg Ser Phe Gly Ala Ile Cys 
    850                 855                 860                 


Gln Gly Leu Met Val Glu Tyr Met Leu Gln Asn Arg Asp Ile Ser Met 
865                 870                 875                 880 


Val Gln Thr Glu Thr Gly Asp Gly Lys Thr Asn Lys Lys Gln Ile Tyr 
                885                 890                 895     


Lys His Tyr Arg Thr Leu Leu Tyr Ile Cys Ile Arg Ser Ala Phe Thr 
            900                 905                 910         


Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro Val Leu Thr 
        915                 920                 925             


Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Gln Thr Asp Gly Leu Lys 
    930                 935                 940                 


His Leu Ser Leu Phe Asp His Leu Lys Glu Thr Phe Asn Asp Ala Glu 
945                 950                 955                 960 


Ser Gly Ser Phe Trp Tyr Met Ala Ala His Phe Ile Asn Gln Lys Tyr 
                965                 970                 975     


Leu Asn His Leu Ile Gly Ser Ile Arg Asn Tyr Leu Gln Phe Thr Glu 
            980                 985                 990         


Asp Ile Glu Asp Arg Ala Leu Ser  Leu Gly Asp Cys Val  Asp Asn Lys 
        995                 1000                 1005             


Arg Glu  Glu Lys Asn Leu Arg  Tyr Arg Asn Thr Leu  Glu Ile Leu 
    1010                 1015                 1020             


Glu Phe  Val Ala Gln Phe Cys  Glu Arg Thr Thr Asn  Val Met Glu 
    1025                 1030                 1035             


Asp Tyr  Phe Glu Ser Asn Gln  Glu Tyr Ala Ala Tyr  Leu Ser Gly 
    1040                 1045                 1050             


Phe Val  Asp Tyr Asn Val Ser  Lys Lys Glu Thr Asp  Ile Glu Lys 
    1055                 1060                 1065             


Ala Leu  Tyr Gly Phe Cys Arg  Gln Lys Phe Lys Val  Asp Gly Lys 
    1070                 1075                 1080             


Glu Tyr  Met Ala Gly Ile Tyr  Tyr Asp Gly Glu Asn  Leu Ile Pro 
    1085                 1090                 1095             


Asn Arg  Asn Ile Ile Arg Ala  Asn Met Tyr Gly Asn  Val Ser Cys 
    1100                 1105                 1110             


Leu Lys  Pro Tyr Met Asp Arg  Ile Thr Leu Lys Glu  Ile Arg Thr 
    1115                 1120                 1125             


Met Tyr  Ala Asp Gln Asn Lys  Leu Asp Thr Val Leu  Lys Glu Gly 
    1130                 1135                 1140             


Val Cys  Arg Thr Glu Glu Glu  Gln Lys Ala Tyr Arg  Glu Tyr Gln 
    1145                 1150                 1155             


Asn Glu  Lys Asn Arg Ile Glu  Leu Phe Asp Leu Cys  Thr Tyr Thr 
    1160                 1165                 1170             


Gln Ile  Leu Asn Asp Ile Gln  Ala Lys Leu Ile Gly  Trp Ser Tyr 
    1175                 1180                 1185             


Met Arg  Glu Arg Asp Leu Met  Tyr Tyr Gln Leu Gly  Tyr Tyr Tyr 
    1190                 1195                 1200             


Thr Lys  Leu Phe Trp Thr Asp  Ser Ile Ser Glu Glu  Asp Ala Arg 
    1205                 1210                 1215             


Arg Arg  Leu Met Gly Glu Leu  Val Asn Val Glu Asp  Gly Val Ile 
    1220                 1225                 1230             


Leu Tyr  Gln Ile Leu Ala Phe  Asn Ser Tyr Asn Leu  Pro Ile Ile 
    1235                 1240                 1245             


Ala Asn  Lys Asn Asn Thr Val  Thr Phe Leu Lys Gly  Glu Gly Ser 
    1250                 1255                 1260             


Ile Gly  Gly Lys Ala Ile Thr  Ala Phe Leu Lys Asn  Tyr Glu Asn 
    1265                 1270                 1275             


Ala Glu  Arg Ile Tyr Glu Glu  Ala Leu Asp Leu Phe  Glu Asn Thr 
    1280                 1285                 1290             


Asp Glu  His Ala Ala Ile Ile  Asn Thr Arg Asn Tyr  Ile Glu His 
    1295                 1300                 1305             


Phe Lys  Tyr Phe Ile Lys Ser  Asp Arg Ser Met Met  Asp Leu Tyr 
    1310                 1315                 1320             


Ser Glu  Val Tyr Asp Arg Phe  Phe Arg His Asp His  Asn Arg Lys 
    1325                 1330                 1335             


Lys Asn  Val Pro Asp Ser Leu  Lys Asn Val Leu Ala  Asp Asn Phe 
    1340                 1345                 1350             


Met Ile  Ala Asp Ile Ser Met  Glu Leu Gly Ser Lys  Lys Val Gly 
    1355                 1360                 1365             


Glu Lys  Lys Lys Gly Phe Arg  Glu His Lys Ala Ala  Arg Ile Glu 
    1370                 1375                 1380             


Phe Thr  Asp Arg Gly Ile Arg  Ser Thr Asp Met Thr  Tyr Thr Val 
    1385                 1390                 1395             


Lys Pro  Asp Pro Lys Asp Ser  Lys Lys Asp Glu Lys  Val Leu Val 
    1400                 1405                 1410             


Pro Ala  Arg Ser Glu Val Phe  Leu Lys Gln Phe Gln  Lys Ile Leu 
    1415                 1420                 1425             


Glu Tyr  Arg Ile 
    1430         


<210>  619
<211>  949
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  619

Met Pro His Gln Lys Lys Met Ala Glu Arg Ile Lys Phe Val Asn Tyr 
1               5                   10                  15      


Gly Tyr Tyr Leu Arg Leu Lys Lys Asn Cys Ala Asp Ser Phe Glu Tyr 
            20                  25                  30          


Tyr Trp Cys Asp Tyr Ile Lys Glu Phe Ile Glu Glu Asn Tyr Val Thr 
        35                  40                  45              


Lys Ile Lys Glu Ala Lys Gly Lys Asn Gly Arg Gln Leu Thr Glu Glu 
    50                  55                  60                  


Asn Cys Asn Ser Glu Ala Met Leu Ser Lys Cys Trp His Asp Met Ile 
65                  70                  75                  80  


Arg His Met Cys Ala Lys Tyr Met Asp Leu Gly Lys Ala Val Tyr His 
                85                  90                  95      


Phe Met Leu Pro Gly Lys Ala Glu Gly Asn Asp Leu Cys Leu Asp Arg 
            100                 105                 110         


Leu Asn Asp Ser Phe Ser Lys Gly Ile Thr Ser Phe Asp Tyr Glu Asn 
        115                 120                 125             


Ile Lys Ala Glu Glu Asn Leu Gln Lys Ala Met Phe Gly Val Leu Val 
    130                 135                 140                 


Ser Gly Thr Phe Asn Phe Ser Arg Ser Val Ala Asp Tyr Ser Gly Pro 
145                 150                 155                 160 


Ala Ala Ala Lys Leu Ala Lys Glu Leu Arg Ala Glu Gly Lys Thr Leu 
                165                 170                 175     


Asn Glu Asp Val Leu Met Val Asp Glu Ala His Leu Lys Ala Ile Leu 
            180                 185                 190         


Tyr Ser Asp Ala Lys Arg Lys Leu Leu Arg Tyr Phe Gly Gly Ser Ser 
        195                 200                 205             


Ala Cys Glu Ala Leu Gly Leu Asp Lys Asp Lys Met Val Leu Glu Phe 
    210                 215                 220                 


Arg Gln Ile Phe Arg Gly Leu Arg Asn Ser Ala Phe His Tyr Thr Asp 
225                 230                 235                 240 


Gly Lys Lys Ala Asp Ile Lys Phe Asp Val Thr Arg Gln Leu Trp Ile 
                245                 250                 255     


Gln Asp Val Gln Ala Asn Lys Gln Leu Ile Leu Asp Lys Tyr Tyr Ser 
            260                 265                 270         


Asn Asn Val Cys Arg Tyr Tyr Lys Pro Glu Met Val Lys Lys Leu Ile 
        275                 280                 285             


Gly Asn Leu Tyr His Gly Tyr Val Glu Gln Glu Ala Gln Ile Pro Ala 
    290                 295                 300                 


Phe Arg Thr Val Trp Lys Arg Lys Asp Phe Ala Lys Tyr Leu Asn Asp 
305                 310                 315                 320 


Ser Asn Phe Leu Pro Val Asn Ile Lys Asn Asp Val Lys Glu Arg Thr 
                325                 330                 335     


Val Phe Glu Gly Ala Leu Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg 
            340                 345                 350         


Lys Tyr Thr Val Gly Gln Asp Ala Pro Lys Tyr Phe Phe Glu Ala Val 
        355                 360                 365             


Arg Ala Tyr Ser Asp Glu His Ala Lys Asn Lys Gln Asp Pro Tyr Ala 
    370                 375                 380                 


Asn Gln Ala Lys Asn Phe Trp Asp Tyr Val Glu Lys Leu Gln Lys Ser 
385                 390                 395                 400 


Tyr Glu Lys Gly Thr Leu Thr Phe Gly Ala Val Cys Gln Thr Ile Met 
                405                 410                 415     


Thr Glu Phe Val Gln Gln Asn Ser Lys Ala Thr Glu Lys Glu Gly Glu 
            420                 425                 430         


Ile Tyr Gln His Phe Lys Val Leu Phe Pro Leu Cys Met Gln Arg Gly 
        435                 440                 445             


Phe Glu Lys Tyr Val Lys Glu Lys His Gly Tyr Leu Leu Lys Pro Trp 
    450                 455                 460                 


Leu Asp Thr Val Val Arg Glu Asn Val Leu Gln Asp Ala Ala Ile Thr 
465                 470                 475                 480 


Cys Phe Asp Asp Leu Met Arg Asp Ala Glu Asp Arg Glu Tyr Ser Trp 
                485                 490                 495     


Tyr Val Val Ala His Phe Ile His Pro Lys Lys Leu Asn His Phe Val 
            500                 505                 510         


Gly Ala Leu Lys Asp Tyr Leu Gln Phe Lys Gln Asp Ile Phe Arg Arg 
        515                 520                 525             


Cys Ser Phe Ala Asn Ile Tyr Ser Glu Gly Glu Leu Ser Gln Lys Lys 
    530                 535                 540                 


Ala Met Leu Ala Glu Lys Glu Ala Glu Ile Ser Glu Ile Leu Arg Val 
545                 550                 555                 560 


Met Glu Phe Val Arg Gly Ile Thr Gly Arg Val Ser Lys Thr Phe Ser 
                565                 570                 575     


Asp Tyr Tyr Glu Asn Glu Glu Val Tyr Ala Asn Tyr Leu Gly Lys Tyr 
            580                 585                 590         


Ile Asp Phe Pro Lys Thr Asp Gly Ile Ser Val Phe Glu Ser Phe Arg 
        595                 600                 605             


Asp Phe Cys Thr Asn Thr Leu Pro Asp Gly Asn Val Leu Asp Val Tyr 
    610                 615                 620                 


Met Asp Glu Lys Asn Pro Arg Leu Leu Lys Asn Val Glu Leu Ala Arg 
625                 630                 635                 640 


Met Tyr Ala Gly Gly Asp Val Ala Leu Lys Lys Arg Lys Arg Ile Thr 
                645                 650                 655     


Ala Lys Asp Leu Gln Arg Tyr Tyr Gly Asn Glu Val Ala Val Gln Lys 
            660                 665                 670         


Ile Leu Gln Lys Gly Leu Cys Ser Thr Arg Glu Glu Gln Gln Arg Val 
        675                 680                 685             


Leu Glu Gln Gln Asn Leu Arg Gly Arg Ile Thr Leu Asn Asp Val Thr 
    690                 695                 700                 


Glu Ile Gln Glu Ile Ile Ser Asp Met Leu Ser Gln Leu Val Thr Phe 
705                 710                 715                 720 


Ser Tyr Phe Arg Glu Arg Asp Gln Met Tyr Leu Leu Leu Gly Phe Tyr 
                725                 730                 735     


Tyr Met Ala Leu Gln Thr Asn Arg Gly Ser Ser Trp Gly Asn Glu Thr 
            740                 745                 750         


Ile Asp Phe Cys Ala Gly Lys Lys Ile Ser Ile Lys Gln Gly Trp Val 
        755                 760                 765             


Leu His Gln Val Arg Ser Val Phe Thr Tyr Gly Leu Lys Leu Tyr Ser 
    770                 775                 780                 


Glu Leu Asp Glu Lys Gly Val Gly Gly Gln Leu Ser Ser Lys Ile Val 
785                 790                 795                 800 


Ala Phe Glu Arg Val His Arg Thr Ser Leu Ala Cys Ala Leu Arg Leu 
                805                 810                 815     


Phe Met Asp Glu Asn Cys Ser Arg Arg Ala Val Asp Val Arg Asn Tyr 
            820                 825                 830         


Val Asp His Phe Lys Tyr Tyr Phe Lys Ala Asp Arg Ser Ile Met Glu 
        835                 840                 845             


Leu Tyr Ser Ala Tyr Tyr Asp Cys Phe Phe Asp Tyr Ser Thr Lys Met 
    850                 855                 860                 


Arg Lys Ser Val Leu Leu Asn Phe Ile Ser Ile Leu Glu Arg His Phe 
865                 870                 875                 880 


Val Val Ser Lys Leu Arg Val Asn Cys Leu Glu Glu Arg Cys Ser Val 
                885                 890                 895     


Ser Phe Ala Glu Ser Leu Lys Ser Glu Lys Phe Thr Tyr Lys Leu Glu 
            900                 905                 910         


Ala Asp Ala Asn Lys Lys Ser Lys Glu Gln Thr Val Glu Phe Pro Ala 
        915                 920                 925             


Arg Asp Lys Glu Phe Leu Glu Ser Leu Gln Ala Glu Leu Glu Tyr Lys 
    930                 935                 940                 


Glu Gly Tyr Asn Ser 
945                 


<210>  620
<211>  1315
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  620

Met Ala Glu Thr Leu Thr Phe Thr Asn Leu Tyr Asp Ile Leu Thr Leu 
1               5                   10                  15      


Ile Asp Ser Gly Leu Asn Leu His Ile Asn Leu Gly Val Ile Ile Met 
            20                  25                  30          


Lys Leu Thr Arg Arg Arg Ile Ser Gly Asn Ser Val Asp Gln Lys Ile 
        35                  40                  45              


Thr Ala Ala Phe Tyr Arg Asp Met Ser Gln Gly Leu Leu Tyr Tyr Asp 
    50                  55                  60                  


Ser Glu Asp Asn Asp Cys Thr Asp Lys Val Ile Glu Ser Met Asp Phe 
65                  70                  75                  80  


Glu Arg Ser Trp Arg Gly Arg Ile Leu Lys Asn Gly Glu Asp Asp Lys 
                85                  90                  95      


Asn Pro Phe Tyr Met Phe Val Lys Gly Leu Val Gly Ser Asn Asp Lys 
            100                 105                 110         


Ile Val Cys Glu Pro Ile Asp Val Asp Ser Asp Pro Asp Asn Leu Asp 
        115                 120                 125             


Ile Leu Ile Asn Lys Asn Leu Thr Gly Phe Gly Arg Asn Leu Lys Ala 
    130                 135                 140                 


Pro Asp Ser Asn Asp Thr Leu Glu Asn Leu Ile Arg Lys Ile Gln Ala 
145                 150                 155                 160 


Gly Ile Pro Glu Glu Glu Val Leu Pro Glu Leu Lys Lys Ile Lys Glu 
                165                 170                 175     


Met Ile Gln Lys Asp Ile Val Asn Arg Lys Glu Gln Leu Leu Lys Ser 
            180                 185                 190         


Ile Lys Asn Asn Arg Ile Pro Phe Ser Leu Glu Gly Ser Lys Leu Val 
        195                 200                 205             


Pro Ser Thr Lys Lys Met Lys Trp Leu Phe Lys Leu Ile Asp Val Pro 
    210                 215                 220                 


Asn Lys Thr Phe Asn Glu Lys Met Leu Glu Lys Tyr Trp Glu Ile Tyr 
225                 230                 235                 240 


Asp Tyr Asp Lys Leu Glu Ala Asn Ile Thr Asn Arg Leu Asp Lys Thr 
                245                 250                 255     


Asp Lys Asn Ala Arg Ser Ile Ser Arg Ala Val Ser Asp Glu Leu Arg 
            260                 265                 270         


Glu Tyr His Lys Tyr Leu Arg Thr Asn Tyr Asn Arg Phe Val Ser Gly 
        275                 280                 285             


Asp Arg Pro Ala Ala Gly Leu Asp Asn Gly Gly Ser Ala Lys Tyr Asn 
    290                 295                 300                 


Pro Asp Lys Glu Glu Phe Leu Leu Phe Leu Lys Glu Val Glu Gln Tyr 
305                 310                 315                 320 


Phe Lys Lys Tyr Phe Pro Val Lys Ser Lys His Ser Asn Lys Ser Lys 
                325                 330                 335     


Asp Lys Ser Leu Val Asp Lys Tyr Lys Asn Tyr Cys Ser Tyr Lys Val 
            340                 345                 350         


Val Lys Lys Glu Val Asn Arg Ser Ile Ile Asn Gln Leu Val Ala Gly 
        355                 360                 365             


Leu Ile Gln Gln Gly Lys Leu Leu Tyr Tyr Phe Tyr Tyr Asn Asp Thr 
    370                 375                 380                 


Trp Gln Glu Asp Phe Leu Asn Ser Tyr Gly Leu Ser Tyr Ile Gln Val 
385                 390                 395                 400 


Glu Glu Ala Phe Lys Lys Ser Val Met Thr Ser Leu Ser Trp Gly Ile 
                405                 410                 415     


Asn Arg Leu Thr Ser Phe Phe Ile Asp Asp Ser Asn Thr Val Lys Phe 
            420                 425                 430         


Asp Asp Ile Thr Thr Lys Arg Ala Lys Glu Ala Ile Glu Ser Asn Tyr 
        435                 440                 445             


Phe Asn Lys Leu Arg Thr Cys Ser Arg Met Gln Asp His Phe Lys Glu 
    450                 455                 460                 


Lys Leu Ala Phe Phe Tyr Pro Val Tyr Val Lys Asp Lys Lys Asp Arg 
465                 470                 475                 480 


Pro Asp Asp Ile Glu Lys Leu Ile Val Leu Val Lys Asn Ala Ile Glu 
                485                 490                 495     


Ser Val Ser Tyr Leu Arg Asn Arg Ile Phe His Phe Lys Lys Ser Ser 
            500                 505                 510         


Leu Leu Glu Leu Leu Lys Glu Leu Asp Asp Lys Asn Ser Gly Gln Asp 
        515                 520                 525             


Lys Ile Asp Tyr Ser Val Ala Ala Glu Phe Ile Lys Arg Asp Ile Glu 
    530                 535                 540                 


Asn Leu Tyr Asp Val Phe Arg Glu Gln Ile Arg Ser Leu Gly Ile Ala 
545                 550                 555                 560 


Glu Tyr Tyr Lys Ala Asp Met Ile Ser Asp Cys Phe Lys Thr Cys Gly 
                565                 570                 575     


Leu Glu Phe Ala Leu Tyr Ser Pro Lys Asn Ser Leu Met Pro Ala Phe 
            580                 585                 590         


Lys Asn Val Tyr Lys Arg Gly Ala Asn Leu Asn Lys Ala Tyr Ile Arg 
        595                 600                 605             


Asp Lys Gly Pro Lys Glu Thr Gly Asp Gln Gly Gln Asn Ser Tyr Lys 
    610                 615                 620                 


Ala Leu Glu Glu Tyr Arg Glu Leu Thr Trp Tyr Ile Glu Val Lys Asn 
625                 630                 635                 640 


Asn Asp Gln Ser Tyr Asn Ala Tyr Lys Asn Leu Leu Gln Leu Ile Tyr 
                645                 650                 655     


Tyr His Ala Phe Leu Pro Glu Val Arg Glu Asn Glu Ala Leu Ile Thr 
            660                 665                 670         


Asp Phe Ile Asn Arg Thr Lys Glu Trp Asn Arg Lys Glu Thr Glu Glu 
        675                 680                 685             


Arg Leu Asn Thr Lys Asn Asn Lys Lys His Lys Asn Phe Asp Glu Asn 
    690                 695                 700                 


Asp Asp Ile Thr Val Asn Thr Tyr Arg Tyr Glu Ser Ile Pro Asp Tyr 
705                 710                 715                 720 


Gln Gly Glu Ser Leu Asp Asp Tyr Leu Lys Val Leu Gln Arg Lys Gln 
                725                 730                 735     


Met Ala Arg Ala Lys Glu Val Asn Glu Lys Glu Glu Gly Asn Asn Asn 
            740                 745                 750         


Tyr Ile Gln Phe Ile Arg Asp Val Val Val Trp Ala Phe Gly Ala Tyr 
        755                 760                 765             


Leu Glu Asn Lys Leu Lys Asn Tyr Lys Asn Glu Leu Gln Pro Pro Leu 
    770                 775                 780                 


Ser Lys Glu Asn Ile Gly Leu Asn Asp Thr Leu Lys Glu Leu Phe Pro 
785                 790                 795                 800 


Glu Glu Lys Val Lys Ser Pro Phe Asn Ile Lys Cys Arg Phe Ser Ile 
                805                 810                 815     


Ser Thr Phe Ile Asp Asn Lys Gly Lys Ser Thr Asp Asn Thr Ser Ala 
            820                 825                 830         


Glu Ala Val Lys Thr Asp Gly Lys Glu Asp Glu Lys Asp Lys Lys Asn 
        835                 840                 845             


Ile Lys Arg Lys Asp Leu Leu Cys Phe Tyr Leu Phe Leu Arg Leu Leu 
    850                 855                 860                 


Asp Glu Asn Glu Ile Cys Lys Leu Gln His Gln Phe Ile Lys Tyr Arg 
865                 870                 875                 880 


Cys Ser Leu Lys Glu Arg Arg Phe Pro Gly Asn Arg Thr Glu Leu Glu 
                885                 890                 895     


Lys Glu Thr Glu Leu Leu Ala Glu Leu Glu Glu Leu Met Glu Leu Val 
            900                 905                 910         


Arg Phe Thr Met Pro Ser Ile Pro Glu Ile Ser Ala Lys Ala Glu Ser 
        915                 920                 925             


Gly Tyr Asp Thr Met Ile Lys Lys Tyr Phe Lys Asp Phe Ile Glu Lys 
    930                 935                 940                 


Lys Val Phe Lys Asn Pro Lys Thr Ser Asn Leu Tyr Tyr His Ser Asp 
945                 950                 955                 960 


Ser Lys Thr Pro Val Thr Arg Lys Tyr Met Ala Leu Leu Met Arg Ser 
                965                 970                 975     


Ala Pro Leu His Leu Tyr Lys Asp Ile Phe Lys Gly Tyr Tyr Leu Ile 
            980                 985                 990         


Thr Lys Lys Glu Cys Leu Glu Tyr  Ile Lys Leu Ser Asn  Ile Ile Lys 
        995                 1000                 1005             


Asp Tyr  Gln Asn Ser Leu Asn  Glu Leu His Glu Gln  Leu Glu Arg 
    1010                 1015                 1020             


Ile Lys  Leu Lys Ser Glu Lys  Gln Asn Gly Lys Asp  Ser Leu Tyr 
    1025                 1030                 1035             


Leu Asp  Lys Lys Asp Phe Tyr  Lys Val Lys Glu Tyr  Val Glu Asn 
    1040                 1045                 1050             


Leu Glu  Gln Val Ala Arg Tyr  Lys His Leu Gln His  Lys Ile Asn 
    1055                 1060                 1065             


Phe Glu  Thr Leu Tyr Arg Ile  Phe Arg Ile His Val  Asp Ile Ala 
    1070                 1075                 1080             


Ala Arg  Met Val Gly Tyr Thr  Gln Asp Trp Glu Arg  Asp Met His 
    1085                 1090                 1095             


Phe Leu  Phe Lys Ala Leu Val  Tyr Asn Gly Val Leu  Glu Glu Arg 
    1100                 1105                 1110             


Arg Phe  Glu Ala Ile Phe Asn  Asn Asn Asp Asp Asn  Asn Asp Gly 
    1115                 1120                 1125             


Arg Ile  Val Lys Lys Ile Gln  Asn Asn Leu Asn Asn  Lys Asn Arg 
    1130                 1135                 1140             


Glu Leu  Val Ser Met Leu Cys  Trp Asn Lys Lys Leu  Asn Lys Asn 
    1145                 1150                 1155             


Glu Phe  Gly Ala Ile Ile Trp  Lys Arg Asn Pro Ile  Ala His Leu 
    1160                 1165                 1170             


Asn His  Phe Thr Gln Thr Glu  Gln Asn Ser Lys Ser  Ser Leu Glu 
    1175                 1180                 1185             


Ser Leu  Ile Asn Ser Leu Arg  Ile Leu Leu Ala Tyr  Asp Arg Lys 
    1190                 1195                 1200             


Arg Gln  Asn Ala Val Thr Lys  Thr Ile Asn Asp Leu  Leu Leu Asn 
    1205                 1210                 1215             


Asp Tyr  His Ile Arg Ile Lys  Trp Glu Gly Arg Val  Asp Glu Gly 
    1220                 1225                 1230             


Gln Ile  Tyr Phe Asn Ile Lys  Glu Lys Glu Asp Ile  Glu Asn Glu 
    1235                 1240                 1245             


Pro Ile  Ile His Leu Lys His  Leu His Lys Lys Asp  Cys Tyr Ile 
    1250                 1255                 1260             


Tyr Lys  Asn Ser Tyr Met Phe  Asp Lys Gln Lys Glu  Trp Ile Cys 
    1265                 1270                 1275             


Asn Gly  Ile Lys Glu Glu Val  Tyr Asp Lys Ser Ile  Leu Lys Cys 
    1280                 1285                 1290             


Ile Gly  Asn Leu Phe Lys Phe  Asp Tyr Glu Asp Lys  Asn Lys Ser 
    1295                 1300                 1305             


Ser Ala  Asn Pro Lys His Thr  
    1310                 1315 


<210>  621
<211>  1194
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  621

Met Lys Val Thr Lys Ile Asp Gly Leu Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Phe Lys Asn Asn Lys Asn Ile Asn Glu Ile 
            20                  25                  30          


Lys Glu Arg Leu Lys Lys Leu Lys Glu Leu Lys Leu Asp Asn Tyr Ile 
        35                  40                  45              


Lys Asn Pro Glu Asn Val Lys Asn Lys Asp Lys Asp Ala Glu Lys Glu 
    50                  55                  60                  


Thr Lys Ile Arg Arg Thr Asn Leu Lys Lys Tyr Phe Ser Glu Ile Ile 
65                  70                  75                  80  


Leu Arg Lys Glu Asp Glu Lys Tyr Ile Leu Lys Lys Thr Lys Lys Phe 
                85                  90                  95      


Lys Asn Ile Asn Gln Glu Ile Asp Tyr Tyr Asp Val Lys Ser Lys Lys 
            100                 105                 110         


Asn Gln Gln Glu Ile Phe Asp Val Leu Lys Glu Ile Lys Ile Lys Glu 
        115                 120                 125             


Thr Glu Lys Glu Glu Ile Ile Thr Phe Asp Ser Glu Lys Leu Lys Lys 
    130                 135                 140                 


Val Phe Gly Glu Asp Phe Val Lys Lys Glu Ala Lys Ile Lys Ala Ile 
145                 150                 155                 160 


Glu Lys Ser Leu Lys Ile Asn Lys Ala Asn Tyr Lys Lys Asp Ser Ile 
                165                 170                 175     


Lys Ile Gly Asp Asp Lys Tyr Ser Asn Val Lys Gly Glu Asn Lys Arg 
            180                 185                 190         


Ser Arg Ile Tyr Glu Tyr Tyr Lys Lys Ser Glu Asn Leu Lys Lys Phe 
        195                 200                 205             


Glu Glu Asn Ile Arg Glu Ala Phe Glu Lys Leu Tyr Thr Glu Glu Asn 
    210                 215                 220                 


Ile Lys Glu Leu Tyr Ser Lys Ile Glu Glu Val Leu Lys Lys Thr His 
225                 230                 235                 240 


Leu Lys Ser Ile Val Arg Glu Phe Tyr Gln Asn Glu Ile Ile Gly Glu 
                245                 250                 255     


Ser Glu Phe Ser Lys Lys Asn Gly Asp Gly Ile Ser Ile Leu Tyr Asn 
            260                 265                 270         


Gln Ile Lys Asp Ser Ile Lys Lys Glu Glu Asn Phe Ile Glu Phe Ile 
        275                 280                 285             


Glu Asn Ile Gly Asn Leu Glu Leu Lys Asp Leu Thr Lys Ser Gln Ile 
    290                 295                 300                 


Phe Tyr Lys Tyr Phe Leu Glu Asn Glu Glu Leu Asn Asp Glu Asn Ile 
305                 310                 315                 320 


Lys Phe Ala Phe Cys Tyr Ser Val Glu Ile Glu Val Asn Asn Leu Leu 
                325                 330                 335     


Lys Glu Asn Val Tyr Lys Ile Lys Arg Phe Asn Glu Gly Asn Lys Lys 
            340                 345                 350         


Arg Ile Lys Asn Ile Phe Glu Tyr Gly Lys Leu Lys Lys Leu Ile Val 
        355                 360                 365             


Tyr Lys Leu Glu Asn Lys Leu Asn Asn Tyr Val Arg Asn Cys Gly Lys 
    370                 375                 380                 


Tyr Asn Tyr His Met Glu Asn Gly Asp Ile Ala Thr Ser Asp Ile Asn 
385                 390                 395                 400 


Met Arg Asn Arg Gln Thr Glu Ala Phe Leu Arg Ser Ile Ile Gly Val 
                405                 410                 415     


Ser Ser Phe Gly Tyr Phe Ser Leu Arg Asn Ile Leu Gly Val Asn Asp 
            420                 425                 430         


Asp Asp Phe Tyr Glu Ile Glu Glu Gly Leu Thr Glu Glu Glu Arg Lys 
        435                 440                 445             


Asn Glu Ser Asn Val Leu Lys Lys Ala Lys Glu Asp Ile Thr Ser Lys 
    450                 455                 460                 


Ser Ile Phe Glu Lys Val Val Asp Lys Ser Phe Glu Lys Lys Gly Ile 
465                 470                 475                 480 


His Ser Ile Arg Lys Asn Val Lys Met Phe Tyr Gly Asp Ser Phe Asp 
                485                 490                 495     


Lys Ala Asn Glu Asp Glu Leu Lys Gln Phe Phe Val Asn Met Leu Asn 
            500                 505                 510         


Ala Ile Thr Ser Ile Arg His Arg Val Val His Tyr Asn Met Asn Thr 
        515                 520                 525             


Asn Ser Glu Asn Ile Phe Asn Phe Ser Asp Ile Glu Val Ser Arg Leu 
    530                 535                 540                 


Leu Lys Ser Ile Phe Glu Lys Glu Thr Asp Lys Arg Glu Leu Lys Leu 
545                 550                 555                 560 


Lys Ile Phe Arg Gln Leu Asn Ser Ala Gly Val Phe Asp Tyr Trp Glu 
                565                 570                 575     


Asn Trp Lys Ile Glu Lys Tyr Leu Lys Asn Ile Glu Phe Lys Phe Val 
            580                 585                 590         


Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys Leu Tyr Asn Arg 
        595                 600                 605             


Ile Asp Asn Leu Lys Ala Gly Asn Ala Leu Lys Leu Gly Asn His Ile 
    610                 615                 620                 


Ile Ile Pro Lys Arg Lys Glu Ala Arg Asp Ser Gln Ile Tyr Leu Leu 
625                 630                 635                 640 


Lys Asn Ile Tyr Tyr Gly Glu Phe Val Glu Lys Phe Val Asn Asn Asn 
                645                 650                 655     


Asp Asn Phe Glu Lys Ile Phe Arg Glu Ile Ile Lys Ile Asn Lys Asn 
            660                 665                 670         


Ala Gly Thr Asn Thr Lys Thr Lys Phe Tyr Lys Leu Glu Lys Phe Glu 
        675                 680                 685             


Thr Leu Lys Ala Asn Thr Pro Thr Glu Tyr Leu Glu Lys Leu Gln Ser 
    690                 695                 700                 


Leu His Lys Ile Asn Tyr Asp Lys Glu Lys Val Glu Glu Asp Lys Asp 
705                 710                 715                 720 


Thr Tyr Val Asp Phe Val Gln Lys Ile Phe Leu Lys Gly Phe Ile Asn 
                725                 730                 735     


Tyr Leu Gln Lys Ser Asn Ser Leu Lys Pro Leu Asn Leu Leu Asn Leu 
            740                 745                 750         


Lys Lys Asp Glu Val Ile Asn Ser Glu Lys Ser Ser Tyr Asp Glu Lys 
        755                 760                 765             


Leu Lys Gln Trp Glu Asn Asn Gly Ser Asn Leu Ser Glu Met Pro Lys 
    770                 775                 780                 


Glu Ile Tyr Glu Tyr Ile Lys Lys Ile Gln Ile Asn Lys Ile Asn Tyr 
785                 790                 795                 800 


Ser Asp Arg Met Ser Ile Phe Tyr Leu Leu Leu Lys Leu Ile Asp His 
                805                 810                 815     


Lys Glu Leu Thr Asn Leu Arg Gly Asn Leu Glu Lys Tyr Glu Ser Met 
            820                 825                 830         


Asn Lys Asn Lys Ile Tyr Ser Glu Glu Leu Asn Ile Val Asn Leu Val 
        835                 840                 845             


Ser Leu Asp Asn Asn Lys Val Arg Thr Asn Phe Ser Val Glu Ala Glu 
    850                 855                 860                 


Asp Ile Gly Lys Phe Leu Lys Thr Glu Thr Ser Ile Lys Asn Asn Lys 
865                 870                 875                 880 


Gln Leu Asn Asn Phe Ser Glu Ile Phe Ala Asp Gly Glu Asn Val Ile 
                885                 890                 895     


Lys His Arg Ser Phe Tyr Asn Ile Lys Lys Tyr Gly Ile Leu Asp Leu 
            900                 905                 910         


Leu Glu Lys Ile Val Ala Lys Ala Asp Leu Lys Ile Ala Lys Glu Glu 
        915                 920                 925             


Ile Lys Lys Tyr Glu Asn Leu Gln Lys Glu Leu Glu Lys Asn Asp Phe 
    930                 935                 940                 


Tyr Lys Ile Gln Glu Lys Ile His Arg Lys Tyr Asn Gln Lys Pro Asn 
945                 950                 955                 960 


Leu Ile Leu Arg Thr Glu Asn Lys Lys Asp Phe Asn Asp Tyr Lys Lys 
                965                 970                 975     


Ala Ile Glu Asn Ile Gln Asn Tyr Thr Gln Leu Lys Asn Lys Ile Glu 
            980                 985                 990         


Phe Asn Asp Leu Asn Leu Leu Gln  Gly Leu Leu Phe Arg  Ile Leu His 
        995                 1000                 1005             


Arg Leu  Thr Gly Tyr Thr Ser  Leu Trp Glu Arg Asp  Leu Gln Phe 
    1010                 1015                 1020             


Lys Leu  Lys Gly Glu Phe Pro  Glu Asp Lys Tyr Ile  Asp Glu Ile 
    1025                 1030                 1035             


Phe Asn  Ser Asp Arg Asn Asn  Asn Gln Lys Tyr Lys  Ser Gly Gly 
    1040                 1045                 1050             


Ile Ala  Tyr Lys Tyr Val Asp  Phe Leu Ile Glu Lys  Glu Glu Gly 
    1055                 1060                 1065             


Lys Arg  Ala Gly Lys Asn Lys  Val Lys Lys Arg Ser  Glu Lys Glu 
    1070                 1075                 1080             


Gly Ser  Phe Ile Ile Arg Asn  Tyr Ile Ala His Phe  Asn Tyr Ile 
    1085                 1090                 1095             


Pro Asp  Ala Glu Lys Ser Ile  Leu Glu Ile Leu Glu  Glu Leu Arg 
    1100                 1105                 1110             


Glu Leu  Leu Lys Tyr Asp Arg  Lys Leu Lys Asn Ala  Val Met Lys 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ile Phe Lys  Glu Tyr Gly Phe Ile  Ile Glu Phe 
    1130                 1135                 1140             


Gly Ile  Ser His Glu Ser Asn  Ser Lys Lys Ile Lys  Val Leu Asn 
    1145                 1150                 1155             


Val Glu  Ser Glu Lys Ile Lys  His Leu Lys Asn Asn  Gly Leu Val 
    1160                 1165                 1170             


Thr Thr  Arg Asn Ser Lys Asp  Leu Cys Lys Leu Val  Lys Val Met 
    1175                 1180                 1185             


Leu Glu  Tyr Lys Lys Ser 
    1190                 


<210>  622
<211>  1399
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  622

Met Gly Asn Leu Phe Gly His Lys Arg Trp Tyr Glu Val Ser Asp Arg 
1               5                   10                  15      


Gly Asp Asn Lys Ile Lys Arg Lys Val Lys Val Lys Arg Asn Tyr Asp 
            20                  25                  30          


Gly Asn Lys Tyr Ile Leu Asn Ile Asn Glu Asn Asn Asn Lys Glu Lys 
        35                  40                  45              


Ile Asp Asn Asn Lys Phe Ile Arg Glu Phe Val Asn Tyr Lys Lys Asn 
    50                  55                  60                  


Asp Asn Val Leu Ile Glu Phe Lys Arg Lys Phe His Ala Gly Asn Ile 
65                  70                  75                  80  


Leu Phe Lys Leu Lys Gly Asn Lys Arg Ser Ile Glu Asp Ser Asn Asp 
                85                  90                  95      


Phe Leu Lys Thr Glu Glu Ile Ile Leu Asp Lys Glu Val Tyr Gly Gln 
            100                 105                 110         


Ser Glu Lys Leu Arg Asn Glu Lys Gly Ile Thr Lys Gln Asp Ile Leu 
        115                 120                 125             


Lys Glu Ile Ile Asp Lys Gly Ile Asp Lys Ser Asn Asp Lys Ile Leu 
    130                 135                 140                 


Val Lys Thr Lys Phe Gly Lys Glu Ile Thr Ile Asn Phe Thr Asp Glu 
145                 150                 155                 160 


Asp Lys Lys Asn Lys Lys Glu Tyr Gln Ile Thr Leu Lys Ile Ile Pro 
                165                 170                 175     


Glu Asn Glu Leu Lys Ile Lys Arg Glu Val Tyr Asn Val Phe Lys Ile 
            180                 185                 190         


Ile Asn Met Asn Leu Tyr Gln Ile Ile Lys Arg Ile Ile Glu Asn Lys 
        195                 200                 205             


Glu Ile Phe Lys Asn Arg Tyr Tyr Asp Glu Ile Leu Lys Glu Lys Leu 
    210                 215                 220                 


Ser Lys Asn Asn Gln Ile Ile Asn Thr Leu Thr Asn Leu Asn Lys Ile 
225                 230                 235                 240 


Arg Lys Glu Ile Arg Asp Asn Arg Asp Asn Ile Ile Gly Phe Val Lys 
                245                 250                 255     


Phe Tyr Leu Asn Val Ser Gly Asp Lys Lys Lys Ser Glu Asn Lys Lys 
            260                 265                 270         


Met Phe Val Glu Lys Ile Leu Asn Thr Asn Val Asp Leu Thr Val Glu 
        275                 280                 285             


Asp Ile Val Asp Phe Ile Val Lys Glu Leu Lys Phe Trp Asn Ile Thr 
    290                 295                 300                 


Lys Arg Ile Glu Lys Val Lys Lys Phe Asn Asn Glu Phe Leu Glu Asn 
305                 310                 315                 320 


Arg Arg Asn Arg Thr Tyr Ile Lys Ser Tyr Val Leu Leu Asp Lys His 
                325                 330                 335     


Glu Lys Phe Lys Ile Glu Arg Glu Asn Lys Lys Asp Lys Ile Val Lys 
            340                 345                 350         


Phe Phe Val Glu Asn Ile Lys Asn Asn Ser Ile Lys Glu Lys Ile Glu 
        355                 360                 365             


Lys Ile Leu Ala Glu Phe Lys Ile Asp Glu Leu Thr Lys Lys Leu Glu 
    370                 375                 380                 


Lys Glu Leu Lys Lys Gly Asn Cys Asp Thr Glu Ile Phe Gly Ile Phe 
385                 390                 395                 400 


Lys Lys His Tyr Lys Val Asn Phe Asp Ser Lys Lys Phe Ser Asn Lys 
                405                 410                 415     


Ser Asp Glu Glu Lys Glu Leu Tyr Lys Ile Ile Tyr Arg Tyr Leu Lys 
            420                 425                 430         


Gly Arg Ile Glu Lys Ile Leu Ile Asn Glu Gln Lys Val Arg Leu Lys 
        435                 440                 445             


Lys Met Glu Lys Ile Glu Ile Glu Lys Ile Leu Asp Glu Ser Val Leu 
    450                 455                 460                 


Ser Glu Lys Ile Leu Lys Arg Val Lys Gln Tyr Thr Leu Glu His Ile 
465                 470                 475                 480 


Met Tyr Leu Gly Lys Leu Ile His Asn Lys Ile Asn Met Ala Thr Val 
                485                 490                 495     


Asn Thr Asn Asp Phe Phe Arg Leu His Ala Lys Glu Glu Leu Asp Leu 
            500                 505                 510         


Glu Leu Ile Thr Phe Phe Ala Ser Thr Asn Met Glu Leu Asn Lys Ile 
        515                 520                 525             


Phe Ser Arg Glu Asn Ile Asn Asn Asp Glu Asn Ile Asp Phe Phe Gly 
    530                 535                 540                 


Gly Asp Arg Glu Lys Asn Tyr Val Leu Asp Lys Lys Asn Leu Asn Ser 
545                 550                 555                 560 


Lys Ile Lys Ile Ile Arg Asp Leu Asp Phe Ile Asp Asn Lys Asn Asn 
                565                 570                 575     


Ile Thr Asn Asn Phe Ile Ser Lys Phe Thr Lys Ile Gly Thr Asn Glu 
            580                 585                 590         


Arg Asn Arg Ile Leu His Ala Ser Ser Lys Glu Arg Asp Leu Gln Gly 
        595                 600                 605             


Thr Gln Asp Asp Tyr Asn Lys Val Ile Asn Ile Ile Gln Asn Leu Lys 
    610                 615                 620                 


Ile Ser Asp Glu Glu Val Ser Lys Ala Leu Asn Leu Asp Val Val Phe 
625                 630                 635                 640 


Lys Asp Lys Lys Asn Ile Ile Thr Lys Ile Asn Asp Ile Glu Ile Ser 
                645                 650                 655     


Glu Glu Asn Asn Ser Val Ile Lys Tyr Leu Pro Ser Phe Ser Lys Val 
            660                 665                 670         


Leu Pro Glu Ile Leu Asn Leu Tyr Lys Asn Lys Asn Lys Asn Asn Pro 
        675                 680                 685             


Phe Asp Thr Thr Glu Thr Glu Arg Ile Ile Leu Asn Ala Leu Ile Tyr 
    690                 695                 700                 


Val Asn Lys Glu Leu Tyr Lys Lys Leu Ile Leu Glu Lys Asn Leu Glu 
705                 710                 715                 720 


Glu Asn Glu Ser Lys Asn Lys Phe Leu Lys Glu Leu Lys Lys Asn Leu 
                725                 730                 735     


Gly Gly Thr Asp Glu Ile Asp Glu Asn Ile Ile Glu Ser Tyr Tyr Lys 
            740                 745                 750         


Asn Thr Gln Ile Ser Ala Ser Lys Gly Asn Asn Lys Ala Ile Lys Lys 
        755                 760                 765             


Tyr Gln Lys Lys Ile Ile Glu Cys Tyr Ile Lys Tyr Leu Glu Glu Asn 
    770                 775                 780                 


Tyr Arg Glu Leu Phe Asp Phe Ser Asp Phe Lys Met Asn Ile Gln Glu 
785                 790                 795                 800 


Ile Lys Lys Gln Ile Lys Glu Ile Asn Asp Asn Lys Thr Tyr Lys Arg 
                805                 810                 815     


Ile Thr Ile Lys Thr Ser Asp Lys Ser Ile Val Ile Asn Asp Asp Phe 
            820                 825                 830         


Glu Tyr Ile Ile Ser Ile Phe Ala Leu Leu Asn Ser Asn Ala Val Ile 
        835                 840                 845             


Asn Lys Ile Arg Asn Arg Phe Phe Ala Thr Ser Val Trp Leu Asp Thr 
    850                 855                 860                 


Ser Glu Tyr Gln Asn Ile Ile Asn Ile Leu Asp Glu Ile Met Gln Leu 
865                 870                 875                 880 


Asn Thr Leu Arg Asn Glu Cys Ile Thr Glu Asn Trp Asn Leu Asn Leu 
                885                 890                 895     


Glu Glu Phe Ile Gln Lys Met Lys Glu Ile Glu Lys Asp Phe Asp Asp 
            900                 905                 910         


Phe Lys Ile Gln Thr Lys Lys Asp Ile Phe Asn Gly Asn Tyr Glu Ser 
        915                 920                 925             


Ile Lys Asn Asn Val Leu Ser Lys Phe Ile Gly Phe Ser Asp Val Gln 
    930                 935                 940                 


Lys Ile Leu Glu Glu Lys Leu Asn Asn Leu Ile Asp Phe Glu Asn Asp 
945                 950                 955                 960 


Asn Glu Ile Lys Lys Ser Val Asn Leu Asp Ser Leu Asn Pro Asp Glu 
                965                 970                 975     


Arg Arg Asn Leu Met Pro Asn Ile Asn Pro Lys Lys Gly Gly Ile Asp 
            980                 985                 990         


Leu Ile Lys Glu Ile Asp Lys Leu  Ile Val Ile Glu Lys  Asn Asn Ile 
        995                 1000                 1005             


Glu Lys  Asn Ile Leu Leu Lys  Ile Ile Phe Asn Ser  Asp Phe Leu 
    1010                 1015                 1020             


Glu Lys  Tyr Lys Lys Glu Ile  Asp Asn Leu Ile Glu  Asp Thr Glu 
    1025                 1030                 1035             


Ser Glu  Asn Lys Asn Lys Phe  Glu Lys Ile Tyr Tyr  Pro Glu Glu 
    1040                 1045                 1050             


His Lys  Asn Glu Leu Tyr Ile  Tyr Lys Lys Asn Leu  Phe Leu Asn 
    1055                 1060                 1065             


Ile Gly  Asn Pro Asn Phe Asp  Lys Ile Tyr Glu Leu  Ile Ser Lys 
    1070                 1075                 1080             


Asp Ile  Lys Asn Ala Asn Thr  Glu Ile Leu Phe Asn  Asp Asp Ile 
    1085                 1090                 1095             


Arg Lys  Asn Lys Ile Ala Glu  Ile Asp Val Ile Leu  Lys Asn Leu 
    1100                 1105                 1110             


Asn Asp  Lys Leu Asn Gly Tyr  Ser Lys Glu Tyr Lys  Glu Lys Tyr 
    1115                 1120                 1125             


Ile Lys  Lys Leu Lys Glu Asn  Gln Glu Asn Ser Asp  Phe Phe Thr 
    1130                 1135                 1140             


Lys Asn  Ile Gln Asn Glu Asn  Tyr Asn Ser Phe Glu  Glu Phe Lys 
    1145                 1150                 1155             


Glu Asp  Tyr Asn Lys Val Ser  Glu Tyr Lys Lys Ile  Arg Asp Leu 
    1160                 1165                 1170             


Val Glu  Phe Asn Tyr Leu Asn  Lys Ile Glu Ser Tyr  Leu Ile Asp 
    1175                 1180                 1185             


Ile Asn  Trp Lys Leu Ala Ile  Gln Met Ala Arg Phe  Glu Arg Asp 
    1190                 1195                 1200             


Met His  Tyr Ile Val Asn Gly  Leu Asp Tyr Leu Tyr  Ile Ile Arg 
    1205                 1210                 1215             


Leu Glu  Lys Asp Arg Asn Gln  Asp Arg Ser Ser Pro  Tyr Pro Lys 
    1220                 1225                 1230             


Tyr Lys  Asn Gly Val Leu Asp  Tyr Thr Lys Ser Tyr  Tyr Asn Phe 
    1235                 1240                 1245             


Lys Asp  Tyr Gln Glu Phe Met  Asp Ile Cys Ser Lys  Phe Gly Ile 
    1250                 1255                 1260             


Asp Leu  Ser Glu Asn Ser Glu  Ile Asn Lys Pro Glu  Asn Glu Ser 
    1265                 1270                 1275             


Ile Arg  Asn Tyr Ile Ser His  Phe Tyr Ile Val Arg  Asn Pro Phe 
    1280                 1285                 1290             


Val Asp  Tyr Ser Ile Ala Glu  Gln Ile Asp Arg Val  Ser Asn Leu 
    1295                 1300                 1305             


Leu Ser  Tyr Ser Thr Arg Tyr  Asn Asn Ser Thr Tyr  Ala Ser Val 
    1310                 1315                 1320             


Phe Glu  Val Phe Lys Lys Asp  Val Asp Leu Asp Tyr  Asp Lys Leu 
    1325                 1330                 1335             


Lys Thr  Lys Phe Lys Leu Phe  Asp Asp Glu Lys Asn  Asp Asp Ile 
    1340                 1345                 1350             


Lys Ile  Leu Glu Ile Lys Asn  Leu Ile Glu Ser Lys  Lys Val Ser 
    1355                 1360                 1365             


Val Leu  Glu Leu Glu Ser Tyr  Asn Ser Asp Tyr Ile  Lys Asn Leu 
    1370                 1375                 1380             


Ile Ile  Glu Leu Leu Thr Lys  Val Glu Asn Lys Asp  Glu Ile Ser 
    1385                 1390                 1395             


Ser 
    


<210>  623
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  623

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Asn Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Tyr Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Asn Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Met 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Glu 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Ile Lys Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Ile Ser Gly Glu Ile Asp Lys Leu Tyr Asp 
            420                 425                 430         


Asn Asn Lys Gln Asn Glu Val Lys Lys Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Ser Lys Asn Glu Ile Glu Asp Phe Phe Ser 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Val 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Lys Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Ser Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Lys Ile Pro Tyr Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Lys Leu Glu Val Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Ile Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala 
865                 870                 875                 880 


Gly Tyr Lys Ile Ser Ile Glu Glu Leu Lys Lys Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Lys Met Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Glu 
        915                 920                 925             


Ser Tyr Lys Gln Ala Ile Lys Asn Ile Glu Glu Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Arg Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Glu Asn Lys  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Lys Phe Tyr Lys Glu  Leu His Gln 
    1010                 1015                 1020             


Asn Asp  Glu Val Lys Ile Asn  Lys Tyr Ser Ser Ala  Asn Ile Lys 
    1025                 1030                 1035             


Val Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Val Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Ile Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Thr Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Lys Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Glu  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  624
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  624

Leu Lys Val Tyr Tyr Lys Tyr Ile Glu Leu Pro Leu Gly Gly Tyr Ala 
1               5                   10                  15      


Val Lys Ile Thr Asn Arg Lys Asn Val Phe Asn Ala Lys Phe Tyr Arg 
            20                  25                  30          


Asn Lys Asp Ile Gly Lys Leu Ile Asn Thr Glu Ser Phe Arg Asp Ile 
        35                  40                  45              


Thr Asp Arg Thr Leu Asp Ser Leu Asp Phe Ile Arg Ser Tyr Lys Gly 
    50                  55                  60                  


Lys Ile Ile Lys Glu Asn Ala Lys Pro Trp Phe Asn Lys Leu Ala Glu 
65                  70                  75                  80  


Tyr Leu Val Asn Glu Gln Cys Lys Asp Phe Asp Tyr Pro Lys Phe Ser 
                85                  90                  95      


Glu Tyr Leu Arg Arg Gln Asp Asn Leu Asp Lys Val Leu Lys Asp Asn 
            100                 105                 110         


Leu Lys Pro Tyr Gly Arg Lys Leu Arg Ser Leu Lys Tyr Glu Thr Arg 
        115                 120                 125             


Ser Leu Ser Glu Ile Leu Leu Asp Asn Asn Ser Ser Asn Ala Glu Lys 
    130                 135                 140                 


Glu Leu Asn His Ile Lys Asp Thr Leu Gln Lys Ile Ile Glu Tyr Lys 
145                 150                 155                 160 


Lys Lys Arg Leu Lys Thr Ser Ile Asn Ser Asn Lys Phe Pro Phe Lys 
                165                 170                 175     


Leu Lys Glu Asn Gly Thr Leu Trp Pro Asn Thr Lys Lys Gly Glu Trp 
            180                 185                 190         


Leu Tyr Ser Phe Ile Glu Lys Glu Pro Asp Asp Val Tyr Lys Lys Leu 
        195                 200                 205             


Glu Glu Tyr Ala Arg Gln Phe Asn Tyr Glu Ser Phe Val Ser Lys Leu 
    210                 215                 220                 


Gly Glu Ser Leu Val Ser Ala Ser Ala Glu Asp Pro Arg Gln Leu Ala 
225                 230                 235                 240 


Lys Thr Ala Glu Ala Val Phe Gln Glu Tyr Tyr Lys Glu Glu Lys Asn 
                245                 250                 255     


Lys His Pro Asn Val Ser Asn Tyr Asp Phe Tyr Leu Arg Glu Val Arg 
            260                 265                 270         


Ala Tyr Ile Lys His Phe Phe Pro Ile Lys Val Gly Lys Asn Val Gly 
        275                 280                 285             


Ala Ser Lys Arg Gln Lys Ala Leu Ala Asn Pro Lys Arg Leu Asp Gly 
    290                 295                 300                 


Arg Cys Ser Ala Lys Asn Met Glu Glu His Val Arg His Gly Ile Leu 
305                 310                 315                 320 


Asn Gln Leu Thr Ala Leu Leu Ile Gln His Gly Lys Ile Val His Tyr 
                325                 330                 335     


Tyr Lys Gly Lys Glu Asp Leu Thr Ser Asn Asp Leu Gln Lys Ile Gln 
            340                 345                 350         


Val Glu Glu Ala Phe Lys Lys Gln Ile Leu Ser Ser Val Ala Phe Ala 
        355                 360                 365             


Thr Ser Arg Leu Asn Tyr Ile Thr Asp Tyr Tyr Gly Glu Ser Tyr Glu 
    370                 375                 380                 


His Gln Lys Ser Arg Ser Leu Asn Phe Phe Lys Pro Asp Ile Arg Thr 
385                 390                 395                 400 


Asn Gly Asn Ser Asn Pro Ser Gly Gly Asp Ile Leu Ser Ser Lys Asn 
                405                 410                 415     


Thr Tyr Tyr Asn Asp Tyr Leu Lys Asn Leu Lys Leu Gln Pro Asp Lys 
            420                 425                 430         


Ser Val Asn Phe Leu Glu Lys Ile Ser Ser Phe Leu Pro Ile Glu Phe 
        435                 440                 445             


Asp Ala Asn Lys Pro Leu Arg Leu Pro Phe Glu Tyr Pro Thr Thr Asp 
    450                 455                 460                 


Leu Leu Pro Glu Gln Ile Leu Leu Glu Glu Ile Lys Glu Ser Ile Asn 
465                 470                 475                 480 


Ala Val Arg Asn Asn Ile Phe His Phe Lys Ser Gly Asn Phe Thr Gln 
                485                 490                 495     


Leu Ile Lys Lys Glu Thr Gln Gly Asp Leu Lys Leu Lys Asp Ser Phe 
            500                 505                 510         


Gly Leu Ser Lys Ala Tyr Leu Lys Tyr Thr Val Ser Gln Ile Asn Ile 
        515                 520                 525             


Ser Phe Ser Lys Arg Ile Glu Ser Met Asn Leu Pro Leu Tyr Tyr Ser 
    530                 535                 540                 


Asn Glu Val Ile Gly Lys Ile Leu Asn Lys Leu Thr Phe Gln Leu Tyr 
545                 550                 555                 560 


Pro Arg Gln Tyr Ser Met Thr Pro Ser Phe Lys Lys Ile Phe Gln Arg 
                565                 570                 575     


Gly Ile Leu Ile Gln Ile His Tyr Lys Asn Ser Lys Pro Phe Ser Trp 
            580                 585                 590         


Phe Val Ser Phe Asn Lys Ile Glu Glu Asn Gln Ala Phe Lys Asn Leu 
        595                 600                 605             


Leu Gln Leu Ile Tyr Gln His Gly Phe Leu Ser Glu Val Phe Lys Asn 
    610                 615                 620                 


Asp Lys Ile Val Leu Asn Cys Ile Asp Lys Val Ile Asp Ile Asn Lys 
625                 630                 635                 640 


Lys Glu Thr Ser Thr Asn Ser Lys Asn Lys His Gln Tyr Gly Tyr Lys 
                645                 650                 655     


Phe Ile Asp Asp Phe Arg Lys Lys Asn Ser Ile Gln Asn Leu Asp Val 
            660                 665                 670         


Phe Leu Gln Ser Leu Gln Ala Ala Ile Ser Lys Ile Glu Asp Asp Ile 
        675                 680                 685             


Leu Glu Thr Gly Ser Glu Asp Val Asn Tyr Val Gln Gln Phe Ile Gln 
    690                 695                 700                 


Asp Leu Tyr Ala Tyr Ala Phe His Asn Tyr Leu Glu Lys Asn Leu Lys 
705                 710                 715                 720 


Leu His Phe Glu Asp Ile Met His Pro Leu Lys Gln Asn Leu Gln Glu 
                725                 730                 735     


Val Glu Ala Thr Leu Asp Lys Leu Lys Gln Ile Asp Ile His Thr Ala 
            740                 745                 750         


Phe Ser Cys His Asn Thr Leu Glu Glu Leu Ala Pro Leu Tyr Leu Phe 
        755                 760                 765             


Phe Ala Leu Leu Asp Ser Ser Glu Ile Asn Arg Leu Gln Gln Gln Phe 
    770                 775                 780                 


Ser Arg Tyr Arg Ile Ala Met Lys Asn Glu Val His Phe Asn Asp Ile 
785                 790                 795                 800 


Glu Asp Tyr Ala Tyr Asn Ile Glu Glu Leu Leu Glu Leu Val Asp Phe 
                805                 810                 815     


Thr Gly Pro Asp Pro Lys Phe Thr Ala Leu Trp Arg Asn Lys Ser Ala 
            820                 825                 830         


Glu Asn Phe Ser Pro Phe Ile Glu Gly Asn Met Pro Cys Tyr Asp Asn 
        835                 840                 845             


Phe Tyr Leu Ser Ser Asp Gln Asn Thr Pro Ile Tyr His Arg Ser Met 
    850                 855                 860                 


Gly Met Leu Asn Arg Ser Gly Val Met Gly Leu Tyr Arg Ile Ile Phe 
865                 870                 875                 880 


Ala Asp Ser Lys Arg Tyr Arg Ile Thr Lys Ala Asp Tyr Gln Ile Tyr 
                885                 890                 895     


Thr Thr Gln Gln Asn Glu Glu Asp Gly Tyr Lys Lys Ile Glu Ser Leu 
            900                 905                 910         


His Ile Lys Ala Asn Glu Leu His Glu Thr Ile Ile Lys Lys Ala Asn 
        915                 920                 925             


Thr Ala Gln Tyr Ile Glu Gly Glu Phe Glu Gln Tyr Lys Lys Tyr Ile 
    930                 935                 940                 


Lys Glu Ile Tyr Thr Tyr Asn Phe Ala Lys Gln Thr Leu Thr Phe Glu 
945                 950                 955                 960 


Thr Leu Tyr Lys Val Phe Gln Ile His Met Glu Val Leu Ser Arg Leu 
                965                 970                 975     


Ile Gly Phe Ala Glu Asp Trp Glu Arg Asp Thr Phe Ala Tyr Leu Thr 
            980                 985                 990         


Ala Ile Glu Asp Leu Lys Gly Asn  Ile Val Glu Pro Gly  Asn Thr Leu 
        995                 1000                 1005             


Asn Lys  Leu Phe Asp Arg Gly  Asn Val Ile Gly Lys  Leu Lys Gly 
    1010                 1015                 1020             


Lys Leu  Asn Gln Ala Gly Lys  Ala Tyr Leu Lys Leu  Phe Tyr Arg 
    1025                 1030                 1035             


Asp Lys  Asp Leu Leu Asn Asp  Ile Asp Ile Arg Asn  Tyr Ile Ala 
    1040                 1045                 1050             


His Leu  Asn His Leu Thr Gln  Phe Ser Lys Asp Asn  Thr Pro Ala 
    1055                 1060                 1065             


His Ser  Leu Ile Glu Thr Ile  Asn Glu Thr Arg Lys  Leu Val Ser 
    1070                 1075                 1080             


Tyr Asp  Asp Lys Arg Gln Asn  Ala Val Thr Lys Ala  Ile Ile Asp 
    1085                 1090                 1095             


Ile Phe  Lys Lys Asn Asn Leu  Thr Leu Val Phe Asn  Arg Ser Asn 
    1100                 1105                 1110             


Asn Ser  Leu Gln Ser Phe Cys  Ile Arg Ser Ile Gln  Pro Val Lys 
    1115                 1120                 1125             


Ile Gln  His Leu Lys Lys Val  Asp Gly Ala Asn Lys  His Gln Leu 
    1130                 1135                 1140             


Phe Phe  Pro Val Arg Ser Glu  Leu Leu Ala Ser Ser  Leu Lys Thr 
    1145                 1150                 1155             


Leu Met  Glu Tyr Lys His Ile  Lys Lys Lys 
    1160                 1165             


<210>  625
<211>  1143
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  625

Met Arg Val Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Val Tyr Ser Gly 
            20                  25                  30          


Gln Pro Val Ser Asn Glu Thr Cys Asn Ile Leu Pro Glu Lys Lys Arg 
        35                  40                  45              


Gln Ser Phe Asp Leu Ser Ile Glu Asn Lys Thr Leu Lys Arg Arg Asp 
    50                  55                  60                  


Asp Val Asp Lys Thr Lys Lys Gly Lys Tyr Asp Ile Val Arg Lys Ile 
65                  70                  75                  80  


Ile Lys Tyr Gly Glu Leu Pro Gln Ser Ile Asn Asp Val Asp Ile Leu 
                85                  90                  95      


Glu Phe Leu Asn His Lys Phe Gln Lys Pro Val Lys Tyr Trp Lys Asn 
            100                 105                 110         


Gly Lys Glu Glu Ser Phe Asn Leu Thr Leu Leu Ile Val Glu Ala Val 
        115                 120                 125             


Lys Thr Gln Asp Arg Gln Lys Leu Gln Pro Tyr Tyr Asp Trp Lys Thr 
    130                 135                 140                 


Trp Tyr Ile Gln Thr Lys Ser Asp Leu Leu Lys Lys Ser Ile Glu Asn 
145                 150                 155                 160 


Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg Lys Lys Ala Leu 
                165                 170                 175     


Leu Ala Trp Glu Thr Glu Phe Thr Thr Ser Gly Lys Ile Asp Leu Thr 
            180                 185                 190         


His Tyr His Lys Val Tyr Met Thr Asp Val Leu Cys Thr Ala Leu Gln 
        195                 200                 205             


Lys Val Glu Pro Ser Thr Asp Lys Lys Gly Lys Ile Asn Thr Asn Ala 
    210                 215                 220                 


Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Thr His Gln Pro Ala Ile 
225                 230                 235                 240 


Phe Gly Thr Arg Gln Ala Pro Asn Asn Val Asn Arg Ala Asp Asp Arg 
                245                 250                 255     


Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu Glu His Tyr Phe 
            260                 265                 270         


Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Ala Asp Asp Ile Glu His 
        275                 280                 285             


Tyr Leu Lys Thr Gln Thr Leu Lys Thr Thr Ile Glu Lys Gln Leu Val 
    290                 295                 300                 


Asn Ala Ile Arg Ala Asn Ile Ile Gln Gln Gly Lys Thr Asn His His 
305                 310                 315                 320 


Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile Arg Ile Lys Thr 
                325                 330                 335     


Asn Glu Ala Phe Val Leu Asn Leu Thr Gly Thr Cys Ala Phe Ala Ala 
            340                 345                 350         


Asn Asn Ile Arg Asn Met Val Asp Asn Glu Gln Thr Asn Asp Ile Leu 
        355                 360                 365             


Gly Lys Gly Asp Phe Ile Lys Ser Leu Leu Lys Asp Asn Thr Asn Gly 
    370                 375                 380                 


Gln Leu Tyr Ser Phe Phe Phe Gly Glu Ser Leu Ser Thr Asn Lys Ala 
385                 390                 395                 400 


Glu Lys Glu Thr Gln Leu Trp Gly Ile Arg Gly Ala Val Gln Gln Ile 
                405                 410                 415     


Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu Lys Thr Val Phe 
            420                 425                 430         


Asn Ile Ser Asn Phe Glu Asn Pro Thr Ile Thr Asp Pro Lys Gln Gln 
        435                 440                 445             


Thr Asn Tyr Ala Asp Thr Ile Tyr Lys Ala Leu Phe Ile Lys Glu Leu 
    450                 455                 460                 


Glu Lys Ile Pro Asn Ala Phe Ala Gln Gln Leu Lys Thr Gly Gly Ala 
465                 470                 475                 480 


Leu Ser Tyr Tyr Thr Ile Glu Asn Leu Lys Ser Leu Leu Thr Thr Phe 
                485                 490                 495     


Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala Pro Gly Phe Lys 
            500                 505                 510         


Lys Val Phe Asn Gly Gly Ile Asn Tyr Gln Asn Ala Lys Gln Asp Glu 
        515                 520                 525             


Ser Phe Tyr Glu Leu Met Leu Glu Arg Tyr Leu Arg Lys Glu Asn Phe 
    530                 535                 540                 


Ala Glu Glu Ala Tyr Asn Ala Arg Tyr Phe Leu Leu Lys Leu Ile Tyr 
545                 550                 555                 560 


Asn Asn Leu Phe Leu Pro Gly Phe Thr Arg Asp Arg Lys Ala Phe Ala 
                565                 570                 575     


Asp Ser Val Gly Phe Val Gln Met Gln Asn Lys Lys Gln Ala Glu Lys 
            580                 585                 590         


Val Asn Pro Lys Lys Arg Glu Ala Tyr Ala Phe Glu Ala Val Arg Pro 
        595                 600                 605             


Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala Tyr Val Gln Ser 
    610                 615                 620                 


Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys Ala Thr Asp Glu 
625                 630                 635                 640 


Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val Phe Val Lys Gly 
                645                 650                 655     


Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe Val Gln Val Pro 
            660                 665                 670         


Gln Pro Gln Leu Thr Ala Thr Ala Ser Asn Gln Gln Lys Ala Asp Lys 
        675                 680                 685             


Leu Asn Gln Leu Glu Ala Ser Ile Thr Ala Asp Cys Lys Leu Thr Pro 
    690                 695                 700                 


Gln Tyr Ala Lys Ala Asp Asn Ala Thr His Ile Ala Phe Tyr Val Phe 
705                 710                 715                 720 


Cys Lys Leu Leu Asp Ala Gly His Leu Ser Asn Leu Arg Asn Glu Leu 
                725                 730                 735     


Ile Lys Phe Arg Glu Ser Val Asn Glu Phe Lys Phe His His Leu Leu 
            740                 745                 750         


Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val Val Pro Thr Asp 
        755                 760                 765             


Tyr Arg Asp Leu Tyr Ser Ser Glu Ala Asp Cys Leu Ala Arg Leu Arg 
    770                 775                 780                 


Pro Phe Ile Glu Gln Gly Ala Asp Ile Thr Asn Trp Ser Asp Leu Phe 
785                 790                 795                 800 


Val Gln Ser Asp Lys His Ser Pro Val Ile His Ala Asn Ile Glu Leu 
                805                 810                 815     


Ser Val Lys Tyr Gly Thr Thr Lys Leu Leu Glu Gln Ile Ile Asn Lys 
            820                 825                 830         


Asp Pro Gln Phe Lys Thr Thr Glu Ala Asn Phe Thr Ala Trp Asn Thr 
        835                 840                 845             


Ala Gln Lys Ser Ile Glu Gln Leu Ile Lys Gln Arg Glu Asp His His 
    850                 855                 860                 


Glu Gln Trp Val Lys Ala Lys Asn Ala Asp Asp Lys Glu Lys Gln Glu 
865                 870                 875                 880 


Arg Lys Arg Glu Lys Ser Asn Phe Ala Gln Lys Phe Ile Glu Lys His 
                885                 890                 895     


Gly Asp Asp Tyr Leu Asp Ile Cys Asp Tyr Ile Asn Thr Tyr Asn Trp 
            900                 905                 910         


Leu Asp Asn Lys Met His Phe Val His Leu Asn Arg Leu His Gly Leu 
        915                 920                 925             


Thr Ile Glu Leu Leu Gly Arg Met Ala Gly Phe Val Ala Leu Phe Asp 
    930                 935                 940                 


Arg Asp Phe Gln Met Leu Asp Ala Lys Arg Ile Ser Asp Leu Tyr Gln 
945                 950                 955                 960 


Leu Lys Ser Phe Ile Ser Phe Arg Glu Ile Thr Ser Glu Leu Asp Lys 
                965                 970                 975     


Asn Asn Asp Ile Thr Glu Ile Asn Leu Ile Lys Asp Lys Glu Ile Ile 
            980                 985                 990         


Lys Arg Asp Gly Thr Pro Ile Thr  Glu Ala Asp Arg Asn  Ser Leu Lys 
        995                 1000                 1005             


Ser Cys  Ile Gln Ser Lys Arg  Glu Tyr Tyr Gln Lys  Thr Tyr Phe 
    1010                 1015                 1020             


Lys Glu  His Thr Asn Pro Phe  Thr Asp Arg Asn Tyr  Ile Ala His 
    1025                 1030                 1035             


Phe Asn  Tyr Leu Ser Thr Asn  Thr Gly Asn His Ser  Leu Ile Lys 
    1040                 1045                 1050             


Leu Ile  Asn Lys Leu Arg Asp  Leu Leu His Tyr Asp  Arg Lys Leu 
    1055                 1060                 1065             


Lys Asn  Ala Val Ser Lys Ala  Phe Ile Asp Leu Phe  Asp Lys His 
    1070                 1075                 1080             


Gly Met  Ile Leu Lys Leu Lys  Leu Asn Thr Asp His  Gln Leu Glu 
    1085                 1090                 1095             


Val Glu  Ser Leu Glu Pro Lys  Lys Ile Tyr His Leu  Gly Ser Ser 
    1100                 1105                 1110             


Ala Lys  Asp Lys Pro Glu Tyr  Gln Tyr Cys Thr Asn  Gln Val Met 
    1115                 1120                 1125             


Met Ala  Tyr Cys Asn Met Cys  Arg Ser Leu Leu Glu  Met Lys Lys 
    1130                 1135                 1140             


<210>  626
<211>  1268
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  626

Met Lys Val Ser Lys Val Asn His Arg Arg Ala Ala Val Ala Val Asn 
1               5                   10                  15      


Lys Lys Ser Val Thr Val Asn Gly Ile Leu Tyr Asp Ala Pro Val Lys 
            20                  25                  30          


Lys Asn Val Lys Thr Gly Asn Met Ser Ala Tyr Val Ser Ser Lys Tyr 
        35                  40                  45              


Val Ile Asp Asn Val Val Lys Asn Ser Ser Arg Leu Tyr Ser Pro Phe 
    50                  55                  60                  


Ser Ser Lys Arg Ile Val Ile Asp Arg Glu Lys Ile Arg Ile Ala Asp 
65                  70                  75                  80  


Arg Leu Lys Gln Cys Tyr Val Asn Phe Val Lys Tyr Tyr Leu Ser Asn 
                85                  90                  95      


Gly Ser Leu Asn Glu Gln Gln Met Arg Phe Asn Pro Asn Asn Thr Tyr 
            100                 105                 110         


Met Ala Asp Ser Arg Val His Phe Cys Val Pro Ser Gly Ile Asp Ile 
        115                 120                 125             


Glu Ser Leu Ile Asn Ser Ile Val Asp Ser Ser Leu Arg Lys Ser Leu 
    130                 135                 140                 


Lys Arg Thr Tyr Arg Phe Glu Thr Asn Tyr Gly Glu Lys Asn Thr Phe 
145                 150                 155                 160 


Asn Leu Pro Asp Leu Val Lys Lys Ser Ile Lys Ile Tyr Cys Thr Asp 
                165                 170                 175     


Glu Lys Arg Lys Leu Asn Asp Arg Glu Glu Gln Glu Met Tyr Val Leu 
            180                 185                 190         


Phe Ser Tyr Met Tyr Glu Asp Lys Tyr Lys Asp Arg Gln Lys Val Leu 
        195                 200                 205             


Ile Ala Asn Ser Ile Ser Asn Gln Ala Thr Lys Val Lys Val Cys Asp 
    210                 215                 220                 


Asp Glu Ser Arg Leu Ile Lys Leu Ser Ile Ala Asp Thr Lys Lys Lys 
225                 230                 235                 240 


Pro Leu Trp Asp Phe Ile Val Asp Tyr Ala Asn Ser Asp Lys Asn Gly 
                245                 250                 255     


Gln Tyr Thr Ile Leu Arg Asn Ile Arg Lys Ser Ile Val Leu Phe Val 
            260                 265                 270         


Cys Gly Val Asp Val Tyr Arg Asn Ile Glu Asn Asn Asp Asn Leu Asp 
        275                 280                 285             


Ile Trp Lys Trp Glu Glu Tyr Gly Ile Gln Glu Ser Gln Leu Phe Val 
    290                 295                 300                 


Lys Ile Glu Asn Cys Tyr Thr Thr Lys Gly Glu Asp Ile Ala Leu Asn 
305                 310                 315                 320 


Glu Ile Arg Asn Val Asn Leu Asp His Tyr Met Lys Ala Ile Gly Val 
                325                 330                 335     


Leu Asp Asp Glu Arg Ser Lys Phe Trp Phe Gln His Tyr Glu Asn Thr 
            340                 345                 350         


Ile Glu Ala Leu Phe Ser Lys Lys Ser Lys Arg Lys Ile Glu Arg Ile 
        355                 360                 365             


Lys Thr Ala Tyr Leu Cys Glu Tyr Leu Trp Lys Asn Phe Cys Ser Tyr 
    370                 375                 380                 


Val Ala Leu Lys Tyr Val Asp Leu Gly Lys Gly Val Tyr His Phe Thr 
385                 390                 395                 400 


Met Ser Asp Lys Leu Ser Leu Met Asn Lys Asn Thr Asn Glu Asn Gly 
                405                 410                 415     


Ile Lys Phe Gly Glu Val Asp Ser Arg Phe Asn Lys Gly Ile Ser Ser 
            420                 425                 430         


Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Thr Ile Asp Arg Asn Ile 
        435                 440                 445             


Ser Thr Tyr Thr Thr Phe Ala Thr Asn Ile Phe Ala Lys Ser Val Ile 
    450                 455                 460                 


Lys Asp Ser Tyr Arg Gln Lys Lys Ala Gly Asn Ser Asp Ala Leu Gln 
465                 470                 475                 480 


Tyr Asp Asp Glu Thr Tyr Tyr Asn Arg Lys Ala Met Asn Pro Tyr Ala 
                485                 490                 495     


Leu Lys Arg Val Leu Arg Tyr Trp Gly Gly Gln Ser Arg Trp Lys Ser 
            500                 505                 510         


Glu Leu Glu Glu Leu Asn Val Ala Glu Leu Cys Ile Asp Ile Lys Asn 
        515                 520                 525             


Arg Leu Ser Lys Ile Arg Asn Ser Gly Val His Tyr Thr Ser Thr Ser 
    530                 535                 540                 


Ala Leu Lys Gly Asn Asp Asp Asp Ser Ile Val Gly Met Leu Ile Lys 
545                 550                 555                 560 


Lys Asp Phe Asp Asp Ile Lys Asp Val Tyr Ala Ser Lys Tyr Tyr Ser 
                565                 570                 575     


Asn Asn Val Trp Met Phe Tyr Asn Thr Asp Lys Ile Ser Lys Met Met 
            580                 585                 590         


Glu Tyr Leu Tyr Gln Asp Asp Ser Asn Ile Arg Asp Ala Gln Ile Pro 
        595                 600                 605             


Ala Phe Asn Ser Val Ile Lys Arg Lys Asp Met Ala Glu Val Ile Glu 
    610                 615                 620                 


Lys Ile Val Lys Lys Asn Ser Tyr Lys Thr Ile Lys Glu Pro Tyr Gln 
625                 630                 635                 640 


Arg Glu Lys Tyr Arg Ser Cys Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
                645                 650                 655     


Tyr Asn Arg Phe Ile Lys Gln Asp Asn Leu Lys Asp Gln Val Ile Gln 
            660                 665                 670         


Ile Ile Asp Ser Asn Thr Glu Leu Ile Gly Asp Asn Ser Arg Ala Val 
        675                 680                 685             


Asp Asn Leu Lys Lys Arg Ile His Asp Val Asp Ser Gln Thr Met Ser 
    690                 695                 700                 


Phe Gly Glu Leu Cys Gln Val Ile Met Thr Asp Tyr Asn Met Gln Asn 
705                 710                 715                 720 


Gln Glu Asn Lys Ser Ile Lys Ser Lys Glu Arg Gln Asp Lys Asp Arg 
                725                 730                 735     


Lys Asn Gly Ile Asp Asn Ser Tyr Lys His Phe Pro Leu Leu Leu His 
            740                 745                 750         


His Leu Ile Lys Val Ser Phe Leu Lys Phe Ile Lys Thr Asp Glu Lys 
        755                 760                 765             


Leu Ala Phe Ile Arg Glu Pro Arg Ile Thr Glu Trp Asp Lys Thr Leu 
    770                 775                 780                 


Glu Gln Phe Glu Ala Gln Ile Gln Thr Val Asp Ile Tyr Asn Ser Leu 
785                 790                 795                 800 


Lys Met Met Val Ala Glu Asn Lys Ser Leu Leu Asp Trp Tyr Thr Leu 
                805                 810                 815     


Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asp Val 
            820                 825                 830         


Lys Asn Tyr Ile Gln Tyr Leu Ser Asn Ile Asp Lys Arg Ala Gly Ser 
        835                 840                 845             


Val Lys Asn Asn Lys Ser Ala Ser Thr Glu Val Lys Ile Arg Gln Tyr 
    850                 855                 860                 


Ser Glu Ile Val Arg Ile Leu Asp Phe Ser Leu Gln Tyr Ile Gly Arg 
865                 870                 875                 880 


Val Ser Asn Asp Val Thr Asp Tyr Phe Val Asp Glu Asp Glu Tyr Ala 
                885                 890                 895     


Ala Phe Leu Ser Lys Tyr Val Glu Phe Ser Gly Asn Asp Ile Val Ser 
            900                 905                 910         


Met Lys Ala Phe Cys Gln Ser Arg Thr Ala Asn Gly Lys His Thr Ile 
        915                 920                 925             


Gly Leu Tyr Cys Asp Gly Ala Asn Pro Ile Met Asn Arg Asn Ile Ala 
    930                 935                 940                 


Tyr Ala Lys Met Tyr Gly Asn Asp Glu Ile Leu Ser Tyr Ile Tyr Asn 
945                 950                 955                 960 


Lys Val Thr Lys Lys Asp Ile Glu Lys Tyr Tyr Val Ser Gln Asp Asn 
                965                 970                 975     


Leu Glu Lys Val Phe Ala Asp Gly Lys Cys Gln Asp Val Gln Gln Gln 
            980                 985                 990         


Asn Ala Leu Cys Asp Phe Gln Lys  Met Lys Asn His Ile  Glu Leu Thr 
        995                 1000                 1005             


Glu Val  Ser Ile Tyr Thr Asp  Ile Leu Asn Asp Phe  Met Ala Gln 
    1010                 1015                 1020             


Phe Ile  Ser Trp Ala Tyr Leu  Arg Glu Arg Asp Leu  Met Tyr Phe 
    1025                 1030                 1035             


Gln Leu  Gly Leu Asn Tyr Ile  Arg Met Phe Tyr Gly  Thr Tyr Glu 
    1040                 1045                 1050             


Leu Glu  Glu Lys Tyr Tyr Lys  Leu His Gly Glu Asn  Ile Asn Ile 
    1055                 1060                 1065             


Glu Lys  Gly Ala Leu Leu Tyr  Gln Ile Val Ala Met  Tyr Ser His 
    1070                 1075                 1080             


Glu Leu  Pro Ile Tyr Lys Val  Asp Glu Ser Gly Ile  Ala Ile Leu 
    1085                 1090                 1095             


Ala Glu  Lys Gln Gly Ser Ser  Gly Ala Ser Ile Lys  Ser Phe Val 
    1100                 1105                 1110             


Thr Glu  Tyr Cys Lys Glu Glu  Met Lys Lys Ala Tyr  Thr Tyr Glu 
    1115                 1120                 1125             


Asn Gly  Leu Glu Leu Phe Glu  Asp Val Asn Gln His  Asp Asp Leu 
    1130                 1135                 1140             


Ser Lys  Leu Arg Asn Asp Phe  Ala His Met Arg Tyr  Met Ser Ala 
    1145                 1150                 1155             


Arg Asp  Lys Ser Ile Met Asp  Ile Val Ser Glu Ile  Tyr Asn Gly 
    1160                 1165                 1170             


Phe Phe  Ile Tyr Asp Thr Lys  Leu Lys Lys Ser Val  Ser Phe Ile 
    1175                 1180                 1185             


Phe Lys  Asn Ile Leu Met Arg  Tyr Ala Val Asp Val  Asn Ile Glu 
    1190                 1195                 1200             


Phe Cys  His Lys Gly Asp Asn  Glu Asp Thr Asn Asn  Leu Ile Arg 
    1205                 1210                 1215             


Ile Lys  Asp Glu Val Gly Leu  Tyr Ser Asp Lys Tyr  Thr Tyr Lys 
    1220                 1225                 1230             


Val Glu  Asp Asn Asp Thr Val  Asp Ile Glu Val Arg  Asn Ser Glu 
    1235                 1240                 1245             


Phe Leu  Glu Gln Leu Lys Lys  Leu Leu Glu Tyr Lys  Lys Glu Ser 
    1250                 1255                 1260             


Glu Gly  Ser Glu Leu 
    1265             


<210>  627
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  627

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Ile  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  628
<211>  1155
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  628

Met Lys Leu Thr Ala Thr Lys Asn Ser Ser Asn Ala Gln Phe Tyr Arg 
1               5                   10                  15      


Asp Lys Thr Lys Gly Gln Leu Ile Ser Thr Lys Val Asn Asn Thr Ser 
            20                  25                  30          


Lys Ile Ile Glu Lys Ser Asp Lys Thr Lys Asp Ile Ile Glu Asn Leu 
        35                  40                  45              


Asp His Lys Arg Ser Leu Lys Gly Arg Ile Leu Ile Asn Pro Asp Ser 
    50                  55                  60                  


Lys Gly Lys Ile Lys Leu Asn Thr Asn Glu Phe Lys Ile Lys Ile His 
65                  70                  75                  80  


Ile Glu Lys Ile Ile Asn Thr Leu Ile Tyr Asn Asn His Met Ser Glu 
                85                  90                  95      


Leu Tyr Asp Glu Lys Pro Thr Leu Ser Asp Asp Glu Lys Lys Asp Glu 
            100                 105                 110         


Asn Leu Lys Lys Ile Ile Asn Asn Thr Leu Ser Val Tyr Gly Lys Lys 
        115                 120                 125             


Ile Lys Tyr Asn Ser Asn Ser Lys Asn Leu Glu Glu Ile Leu Ile Cys 
    130                 135                 140                 


Tyr Phe Lys Asn Glu Asp Ile Thr Ser Glu Phe Glu Asn Ile Arg Asn 
145                 150                 155                 160 


Tyr Phe Gln Thr Val Ile Thr His Lys Lys Glu Lys Leu Val Lys Ser 
                165                 170                 175     


Ile Lys Asn Asn Lys Ile Pro Phe Asp Leu Asp Asn Asn Ser Leu Gln 
            180                 185                 190         


Pro Asn Ser Glu Lys Met Lys Trp Leu Phe Ser Phe Ile Lys Asn Gly 
        195                 200                 205             


Val Ile Thr Ala Glu Ile Lys Glu Asn Thr Phe Leu Lys Asp Ile Tyr 
    210                 215                 220                 


Lys Tyr Glu Asn Leu Glu Lys Val Leu Asn Glu Glu Leu Asn Asn Gln 
225                 230                 235                 240 


Ile Lys Asn Asn Lys Pro Val Met Thr Lys Lys Leu Tyr Gln Met Val 
                245                 250                 255     


Leu Asp Tyr Asn Gln Asp Ile Tyr Ile Asn His Ile Asn Gly Glu Asn 
            260                 265                 270         


Glu Gln Asp Ser Phe Tyr Leu Asn Glu Ile Arg Glu His Phe Arg Arg 
        275                 280                 285             


Tyr Leu Val Ile Ser Lys Lys Ser Asn Thr Lys Asn Gln Asn Gly Tyr 
    290                 295                 300                 


Asn Glu Lys Ile Lys Pro Glu Lys Ile Arg His His Ile Ala Tyr Glu 
305                 310                 315                 320 


Phe Val Thr Glu Asn Ile Gln Lys His Ile Ile Asn Gln Leu Val Ala 
                325                 330                 335     


Gly Leu Ile Gln Tyr Gly Lys Leu His His Tyr Phe Tyr Asp Lys Thr 
            340                 345                 350         


Thr Ser Ser Trp Gln Lys Glu Lys Leu Asn Ser Asp Gly Leu Ser Glu 
        355                 360                 365             


Ile Gln Val Glu Glu Ala Phe Lys Lys Gln Ile Leu Thr Ser Ile Ser 
    370                 375                 380                 


Ser Gly Ile Ala Lys Leu Asn Tyr Phe Tyr Asn His Gly Ser Gln Asn 
385                 390                 395                 400 


Glu Ser Lys Ile Asn Thr Asp Lys Asn Val Asp Val Leu Asp Ser Asp 
                405                 410                 415     


Lys Val Gln Leu Gln Leu Thr Ser Asp Thr Asp Asp Thr Glu Phe Lys 
            420                 425                 430         


Ile Ser Thr Cys Phe Pro Ile Asp Leu Ala Lys Asp Tyr Leu Asn Leu 
        435                 440                 445             


Glu Lys Phe Ile Asp Thr Ile Arg Gly Asn Ile Asp Lys Ile Arg Asn 
    450                 455                 460                 


Asn Thr Phe His Phe Lys Lys Asn Glu Leu Lys Asn Leu Phe Asn Asp 
465                 470                 475                 480 


Gly Ser Tyr Asn Asn Thr Asn Ile Thr Phe Ile Lys Glu Leu Phe Gln 
                485                 490                 495     


Arg Asp Leu Asn Ser Val Gln Glu Ser Phe Lys Glu Gln Ile Arg Ser 
            500                 505                 510         


Ser Gly Ile Thr Glu Tyr Cys Ser Phe Glu Leu Leu Lys Asn Ile Phe 
        515                 520                 525             


Gln Glu Asn Ser Phe Asp Phe Gln Leu Tyr Ser Pro Gln Tyr Pro Met 
    530                 535                 540                 


Ser Pro Ser Phe Lys Asn Ile Tyr Lys Arg Gly Cys Asn Leu Ser Asn 
545                 550                 555                 560 


Ala Thr Val Lys Asp Glu Lys Ile Lys Trp Ile Lys Pro Leu Asp Ala 
                565                 570                 575     


Asp Ala Glu Asn Asp Gly Gln Leu Ala Tyr Lys Asn Leu Leu Gln Leu 
            580                 585                 590         


Ile Tyr Tyr His Cys Phe Leu Pro Tyr Val Phe Lys Asn Glu Ser Tyr 
        595                 600                 605             


Leu Ile Lys Tyr Ile Lys Thr Thr Lys Asp Trp Asn Gln Gln Lys Ala 
    610                 615                 620                 


Lys Asn Asp Arg Gln Asn Arg His Gln Tyr Arg Tyr Glu Asn Met Pro 
625                 630                 635                 640 


Phe Tyr Asn Asn Asn Lys Phe Thr Ser Leu Asn Asp Tyr Phe Gln Asn 
                645                 650                 655     


Leu Gln Arg Leu Gln Ser Ile Tyr Glu Asn Asp Glu Asp Ala Lys His 
            660                 665                 670         


Glu Asn Tyr Tyr Leu Asp Phe Ile Gln Asp Ile Phe Leu Leu Ala Phe 
        675                 680                 685             


Asp Asn Tyr Leu Glu Asp Lys Leu Lys Asn Tyr Lys Tyr Lys Leu Ile 
    690                 695                 700                 


Phe Ser Glu Lys Leu Val Asp Ser Ser Leu Glu Ser Leu Glu Thr Leu 
705                 710                 715                 720 


Glu Lys Leu Phe Glu Lys Thr Asn Thr Ile Leu Lys Met Asn Val Asn 
                725                 730                 735     


Ser Ser Phe Glu Asn Asn Leu Asn Phe Tyr Ala Phe Leu Arg Val Leu 
            740                 745                 750         


Glu Lys Arg Glu Leu Asn Asn Leu Leu His Gln Ile Ile Lys Tyr Arg 
        755                 760                 765             


Thr Ser Lys Asn Glu Glu Ser Leu Arg Glu Ile Glu Glu Leu Ile Thr 
    770                 775                 780                 


Leu Val Gln Tyr Thr Ile Pro Leu Gln Thr Ala Asp Glu His Phe Gln 
785                 790                 795                 800 


Asn Glu Leu Lys Asn His Phe Lys Tyr Phe Phe Glu Asp Glu Asn Phe 
                805                 810                 815     


Asn Asn Asn Cys Glu Leu Tyr Tyr Gln Ser Asp Lys Lys Thr Pro Ile 
            820                 825                 830         


Ala His Arg Ser Met Ser Leu Met Gly Arg Ser Gly Ile Met Ala Leu 
        835                 840                 845             


Phe Lys Val Met Phe Ser Thr Asp Tyr Lys Ile Lys Lys Glu Asp Phe 
    850                 855                 860                 


Asp Asn Tyr Leu Lys Met Ile Asp Ser Ala Glu Leu Ile Asn Asp Glu 
865                 870                 875                 880 


Thr Pro Lys Ser Ile Gln Asp Lys Gln Lys Lys Val His Asp Leu His 
                885                 890                 895     


Arg Glu Leu Val Ser Lys Lys Ile Ile Asn Ile Lys Asn Lys Asp Glu 
            900                 905                 910         


Ile Asp Lys Leu Glu Glu Tyr Glu Lys Leu Val Lys Glu Ile Lys Glu 
        915                 920                 925             


Tyr Glu His Leu Arg His Lys Leu Thr Phe Glu Thr Leu Tyr Lys Val 
    930                 935                 940                 


Tyr Lys Ile Tyr Ile Asp Ile Ile Ser Arg Leu Ala Ser Phe Ala Glu 
945                 950                 955                 960 


Asp Trp Glu Arg Asp Met Tyr Phe Met Met Ile Ala Leu Lys Glu Leu 
                965                 970                 975     


Asn His Ile Asn Gln Asn Val Asp Ile Asp Glu Ile Phe Asn Tyr Asn 
            980                 985                 990         


Pro Val Asp Lys Lys Thr Val Ser  Gln Lys Phe Lys Glu  Asn Leu Gly 
        995                 1000                 1005             


Lys Thr  Ile Lys Asn Lys Asn  Leu Val Leu Phe Leu  Phe Trp Met 
    1010                 1015                 1020             


Asp Asn  Ser Lys Asn Asn Ser  Asn Asn Phe Leu Val  Arg Asn Ser 
    1025                 1030                 1035             


Ile Ala  His Leu Asn His Met  Asn Gln Tyr Lys Leu  Asn Asp Ala 
    1040                 1045                 1050             


His Ser  Gln Lys Asn Ile Ile  Glu Leu Ile Asn Arg  Ile Arg Ile 
    1055                 1060                 1065             


Leu Leu  Ala Tyr Asp Leu Lys  Arg Gln Asn Ser Val  Thr Lys Ser 
    1070                 1075                 1080             


Ile Ile  Glu Ile Leu Glu Lys  Gln His Asp Ile Lys  Ile Lys Phe 
    1085                 1090                 1095             


Thr Gly  Lys Lys Asp Asn Asn  Asn Tyr Asn Phe Glu  Leu Asn Ser 
    1100                 1105                 1110             


Val Glu  Ser Asp Asn Ile Ile  His Leu Lys Lys Ile  Gln Lys Asp 
    1115                 1120                 1125             


Lys Asp  Asn Lys Ile Lys Ile  Pro Thr His Asp Glu  Leu Thr Ile 
    1130                 1135                 1140             


Lys Leu  Val Glu Lys Leu Leu  Thr Phe Lys Phe Gln  
    1145                 1150                 1155 


<210>  629
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  629

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Asp Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn Tyr Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Gly Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Gly Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Lys Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Arg Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Asp Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  630
<211>  1140
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  630

Met Arg Gly Asp Tyr Met Lys Ile Thr Lys Ile Asp Gly Ile Ser His 
1               5                   10                  15      


Lys Lys Tyr Lys Glu Lys Gly Lys Leu Ile Lys Ser Asn Glu Ile Glu 
            20                  25                  30          


Lys Asp Val Thr Glu Glu Arg Phe Asn Asp Ile Glu Val Lys Thr Thr 
        35                  40                  45              


Glu Leu Phe Gln Lys Thr Leu Asp Phe Tyr Val Lys Asn Tyr Glu Lys 
    50                  55                  60                  


Cys Glu Glu Gln Asn Lys Glu Arg Arg Glu Lys Ala Lys Asn Tyr Phe 
65                  70                  75                  80  


Ser Lys Val Lys Leu Ile Val Asp Asn Lys Lys Ile Thr Ile Phe Asn 
                85                  90                  95      


Glu Asn Thr Glu Lys Ile Glu Ile Glu Gly Phe Asn Glu Tyr Asp Val 
            100                 105                 110         


Arg Asp Glu Lys Tyr Phe Asn Val Leu Asn Lys Ile Leu Lys Glu Glu 
        115                 120                 125             


Asn Cys Thr Glu Glu Asp Leu Glu Val Phe Glu Asn Asp Leu Gln Lys 
    130                 135                 140                 


Lys Leu Asn Gln Ile Gln Ser Ile Lys Asn Ser Leu Glu Glu Asn Lys 
145                 150                 155                 160 


Ala His Phe Lys Lys Glu Ser Val Asn Asn Thr Ala Asp Arg Val Lys 
                165                 170                 175     


Gly Asn Asn Lys Lys Ser Leu Phe Tyr Glu Tyr Tyr Arg Asn Ser Ser 
            180                 185                 190         


Lys His Gln Glu Tyr Val Asn Asn Ile Phe Glu Ala Phe Asp Lys Leu 
        195                 200                 205             


Tyr Ser Asn Ser His Glu Asp Met Asn Asn Leu Phe Ser Ala Ile Thr 
    210                 215                 220                 


Lys Asp Ser Asn Asp Arg Asn Ile Lys Lys Ile Arg Glu Ala Tyr His 
225                 230                 235                 240 


Glu Ile Leu Asn Lys Asn Lys Ile Glu Phe Gly Glu Glu Leu Tyr Lys 
                245                 250                 255     


Lys Ile Gln Asp Asn Ile Asn Asn Phe Asp Lys Leu Leu Glu Ile Glu 
            260                 265                 270         


Pro Glu Ile Lys Glu Leu Thr Lys Ser Gln Ile Phe Tyr Lys Tyr Tyr 
        275                 280                 285             


Ile Asp Lys Val Ser Leu Asp Gly Thr Asn Ile Lys His Cys Phe Ser 
    290                 295                 300                 


His Leu Val Glu Ile Glu Val Asn Gln Leu Leu Lys Asn Tyr Val Tyr 
305                 310                 315                 320 


Ser Lys Arg Ser Thr Asn Lys Glu Lys Leu Glu Asn Ile Phe Glu Tyr 
                325                 330                 335     


Cys Lys Leu Lys Asn Leu Val Lys Asn Lys Leu Val Asn Lys Leu Asn 
            340                 345                 350         


Ser Tyr Ile Arg Asn Cys Gly Lys Tyr Asn Ser Tyr Ile Asn Asn Asn 
        355                 360                 365             


Asp Val Val Asn Ser Glu Lys Ile Ser Glu Ile Arg Thr Lys Glu Ala 
    370                 375                 380                 


Phe Leu Arg Ser Ile Ile Gly Val Ser Ser Ser Ala Tyr Phe Ser Leu 
385                 390                 395                 400 


Arg Asn Ile Leu Asn Thr Asp Asn Thr Gln Asp Ile Thr Asn Lys Val 
                405                 410                 415     


Lys Gly Glu Val Glu Lys Leu Tyr Gln Glu Asn Lys Lys Val Lys Leu 
            420                 425                 430         


Glu Glu Arg Leu Lys Leu Phe Phe Gly Asn Asn Phe Asp Ile Asn Asn 
        435                 440                 445             


Gln Gln Glu Ile Glu Asp Phe Leu Met Asn Ile Asp Lys Ile Ile Ser 
    450                 455                 460                 


Asn Ile Arg His Glu Ile Ile His Phe Lys Ile Glu Ala Asn Ala His 
465                 470                 475                 480 


Ser Ile Phe Asp Phe Asn Asn Val Thr Leu Gly Asn Lys Ala Lys Asn 
                485                 490                 495     


Ile Phe Asn Asn Glu Ile Asn Glu Glu Arg Ile Lys Phe Lys Ile Phe 
            500                 505                 510         


Lys Gln Leu Asn Ser Ala Asn Val Phe Asp Tyr Leu Ser Asp Glu Asn 
        515                 520                 525             


Ile Thr Glu Tyr Met Gly Lys Val Ile Phe Ser Phe Thr Asn Arg Asn 
    530                 535                 540                 


Ile Pro Phe Val Pro Ser Phe Arg Lys Ile Tyr Asn Arg Val Gln Asp 
545                 550                 555                 560 


Leu Ala Asn Ser Leu Lys Ile Lys Glu Trp Lys Ile Ser Asp Glu Ser 
                565                 570                 575     


Glu Gly Lys Asp Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Glu 
            580                 585                 590         


Glu Phe Leu Asp Glu Phe Leu Asn Glu Glu Asn Gly Ile Phe Ile Ser 
        595                 600                 605             


Ile Lys Asp Lys Ile Ile Glu Leu Asn Arg Asn Gln Asn Lys Arg Thr 
    610                 615                 620                 


Gly Phe Tyr Lys Leu Glu Lys Phe Glu Lys Ile Glu Glu Lys Asn Pro 
625                 630                 635                 640 


Lys Lys Tyr Leu Glu Ile Ile Gln Ser Leu Tyr Met Ile Asn Ile Glu 
                645                 650                 655     


Glu Ile Asp Asn Glu Glu Lys Asn Ile Phe Leu Asp Phe Ile Gln Lys 
            660                 665                 670         


Ile Phe Leu Lys Gly Phe Phe Glu Phe Ile Lys Asn Asn Tyr Asn Tyr 
        675                 680                 685             


Leu Leu Glu Leu Lys Lys Ile Gln Asp Lys Lys Asn Ile Phe Asp Ser 
    690                 695                 700                 


Glu Met Ser Glu Tyr Ile Ala Gly Glu Lys Thr Leu Glu Asp Val Gly 
705                 710                 715                 720 


Glu Ile Asn Glu Ile Ile Gln Lys Ile Glu Ile Met Lys Ile Asp Lys 
                725                 730                 735     


Ile Leu Asn Leu Thr Asp Lys Ile Asn Cys Phe Tyr Leu Leu Leu Lys 
            740                 745                 750         


Leu Leu Asn Tyr Lys Glu Ile Thr Glu Leu Lys Gly Asn Leu Glu Lys 
        755                 760                 765             


Tyr Gln Ile Leu Ser Lys Thr Asp Ile Tyr Glu Lys Glu Leu Ile Leu 
    770                 775                 780                 


Leu Asn Ile Val Asn Leu Asp Asn Asn Lys Val Lys Ile Glu Lys Phe 
785                 790                 795                 800 


Lys Ile Ser Ala Glu Glu Ile Gly Lys Phe Ile Glu Lys Ile Ser Arg 
                805                 810                 815     


Asn Lys Lys Ile Lys Thr Phe Glu Glu Leu Arg Asn Phe Glu Lys Arg 
            820                 825                 830         


Glu Asn Thr Gly Glu Tyr Tyr Asn Val Tyr Ser Asp Asp Lys Asn Ile 
        835                 840                 845             


Lys Asn Ile Arg Asn Leu Tyr Asn Ile Lys Lys Tyr Gly Met Leu Asp 
    850                 855                 860                 


Leu Leu Glu Arg Ile Ser Glu Lys Ser Asn Tyr Cys Ile Lys Lys Glu 
865                 870                 875                 880 


Asp Leu Glu Glu Tyr Ser Glu Leu Arg Lys Gln Leu Glu Asp Glu Lys 
                885                 890                 895     


Thr Asn Phe Tyr Lys Ile Gln Lys Asp Leu His Tyr Glu Tyr Gln Lys 
            900                 905                 910         


Lys Tyr Lys Asn Phe Ser Lys Lys Asn Asn Pro Glu Asp Tyr Glu Lys 
        915                 920                 925             


Tyr Lys Glu Ser Ile Lys Asn Ile Glu Lys Tyr Val His Leu Lys Asn 
    930                 935                 940                 


Lys Ile Glu Phe Asn Glu Leu Asn Leu Leu Gln Ser Leu Leu Leu Lys 
945                 950                 955                 960 


Ile Leu His Arg Leu Val Gly Phe Thr Ser Ile Trp Glu Arg Asp Leu 
                965                 970                 975     


Arg Phe Arg Leu Ile Gly Glu Phe Pro Asp Glu Leu Asp Val Glu Asp 
            980                 985                 990         


Ile Phe Asp His Arg Glu Arg Tyr  Arg Gly Thr Arg Gly  Gln Ile Cys 
        995                 1000                 1005             


Lys Lys  Tyr Asp Gln Phe Ile  Ser Val His Ile Glu  Tyr Gln Asn 
    1010                 1015                 1020             


Asn Asn  Lys Met Lys Asn Ile  Lys Phe Asp Asp Asn  Asn Pro Ile 
    1025                 1030                 1035             


Arg Asn  Tyr Ile Ala His Phe  Asn Tyr Leu Pro Thr  Pro Lys Tyr 
    1040                 1045                 1050             


Ser Ile  Leu Lys Met Leu Gly  Lys Leu Arg Glu Leu  Leu Asp Tyr 
    1055                 1060                 1065             


Asp Arg  Lys Leu Lys Asn Ala  Val Met Lys Ser Ile  Lys Asp Ile 
    1070                 1075                 1080             


Leu Glu  Glu Tyr Gly Phe Lys  Ala Glu Phe Val Ile  Asn Pro Asp 
    1085                 1090                 1095             


Lys Glu  Ile Ile Leu Asn Ser  Val Lys Ser Val Glu  Ile Ile His 
    1100                 1105                 1110             


Leu Lys  Lys Asn Asp Leu Asn  Ser His Arg Asn Ser  Glu Asp Leu 
    1115                 1120                 1125             


Cys Lys  Leu Val Lys Ala Met  Leu Glu Tyr Ser Glu  
    1130                 1135                 1140 


<210>  631
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  631

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Pro Gly Thr Asp Thr 
            20                  25                  30          


Ile Gly Leu Lys Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Asp Lys Pro Lys Lys 
    50                  55                  60                  


Trp Lys Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Glu Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Ser Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Met Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Tyr Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ser Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Gln Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Leu Tyr Asn Ser Val Phe 
            660                 665                 670         


Ile Arg Lys Asn Phe Pro Glu Asp Ile Ser Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val Tyr Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Asp Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Asp Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asn  Ser Glu Lys Lys Glu  Ala Tyr Gln Lys Ile  Glu Val Asn 
    1100                 1105                 1110             


Gly Asp  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Val  Tyr Ala Pro Asp Glu  Lys Gly Asp 
    1130                 1135                 1140             


Ile Leu  Lys Glu Gln Cys Thr  Lys Gly Gly Ala Gly  Gly Lys Ile 
    1145                 1150                 1155             


Ser Ala  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Lys Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Lys Gln 
    1250                 1255                 1260             


Thr Thr  Ser Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Ser Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Lys  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Val Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Gly Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Pro Asn 
    1370                 1375                 1380         


<210>  632
<211>  1188
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  632

Met Arg Ile Val Lys Pro Tyr Gly Arg Ser His Val Glu Pro Ala Ala 
1               5                   10                  15      


Thr Gly Ser Thr Arg Arg Val Leu Arg Leu Arg Pro Pro Asn Asp Lys 
            20                  25                  30          


Asp Ala Lys Asp Ile Glu Ala Phe Ala Arg Ser His Glu Glu Leu Val 
        35                  40                  45              


Ile Ala Gln Trp Ile Ser Ala Leu Asp Lys Ile Ala Thr Lys Pro Ser 
    50                  55                  60                  


Gly Lys Asp Gly Ala Ser Asp Ala Gln Arg Ala Phe Arg Glu Arg Leu 
65                  70                  75                  80  


Gly Asn Ala Ala Trp Thr Leu Leu Glu Thr Lys Gly Leu Leu Pro Gly 
                85                  90                  95      


Leu Val Thr Arg Arg Glu His Leu Thr Met Leu Trp Arg Ala Lys Val 
            100                 105                 110         


His Pro Tyr Gly Ser Thr Pro Tyr Arg Pro Lys Arg Gly Lys Pro Ala 
        115                 120                 125             


Pro Ser Leu Lys Gly Arg Arg Tyr Glu Arg Phe Ala Gly Gln Leu Glu 
    130                 135                 140                 


Val Asp Lys Val Asp Ala Ala Ala Ile Ala Ala Ser Ile His Ala His 
145                 150                 155                 160 


Leu His Gly Thr Ala Val Pro Ala Val Arg Pro Gly Leu Ile Ala Thr 
                165                 170                 175     


Arg Ala Arg Ser Ile Ala Glu Asn Val Leu Arg Pro Pro Gln Arg Leu 
            180                 185                 190         


Pro Asn Glu Glu Arg Ser Trp Ser Asp Asp Asp Glu Arg Ala Tyr Ala 
        195                 200                 205             


Ala Ala Gly Asp Val Ala Arg Glu Ile Gln Glu Leu Ala Ile Ala Ile 
    210                 215                 220                 


Glu Glu Asp Ala Ser Gln Arg Arg Arg Gly Lys Pro Leu Thr Arg Ser 
225                 230                 235                 240 


Pro Phe Ala Leu Arg Asp Ala Ala Pro Ala Leu Arg Gly Gln Tyr Gly 
                245                 250                 255     


Arg Leu Leu Val Asp Ala Ser Gly Asp Ala Leu Pro Ile Ala Gln Ala 
            260                 265                 270         


Arg Ala Ala Phe Pro Gly Leu Phe Gly Leu His Met Ala Val Arg Asp 
        275                 280                 285             


Cys Tyr Ser Arg Ile Leu Lys Asp His Arg Lys Ser Ser Val Val Arg 
    290                 295                 300                 


Ile Leu Pro Arg Asp Met Glu Glu Leu Leu Arg Leu Val Gly Ala Lys 
305                 310                 315                 320 


Leu Thr Asn Arg Asp Leu Asn Ala Met Val Arg Leu Gly Lys Val Ile 
                325                 330                 335     


His Tyr Gln Ser Ser Leu Gly Val Glu Asp Ser Pro Glu Asn Val Ala 
            340                 345                 350         


Ala Asn Trp Pro Ala Asp Val Ser Gly Ser Glu Phe Trp Thr Ser Ala 
        355                 360                 365             


Gly Gln Ala Gln Ile Lys Arg Asn Glu Ala Phe Val Arg Val Trp Arg 
    370                 375                 380                 


His Val Leu Ala Leu Ala Gln Arg Thr Leu Thr Asp Trp Ile Asp Pro 
385                 390                 395                 400 


Gln Gly Lys Thr Gln Gly Asp Ile Leu Leu Ala Asn Pro Pro Phe Asn 
                405                 410                 415     


Arg Asp Ala Tyr Asn Arg Lys Ser Asp Leu Leu Phe Gly Lys Arg Ala 
            420                 425                 430         


Ser Leu Phe Lys Gly Val Glu Thr Phe Glu Asn Val Val Leu Thr Leu 
        435                 440                 445             


Ala Arg Arg Glu Thr Ala Ala Leu Arg His Gly Ser Phe His Phe Lys 
    450                 455                 460                 


Gly Leu Gly Gly Phe Thr Lys Val Leu Ala Glu Val Pro Lys Thr Asp 
465                 470                 475                 480 


Ala Ser Val Leu Ala Ala Val Arg Thr Leu Trp Glu Asp Asp Leu Ser 
                485                 490                 495     


Glu Arg Ala Gln Arg Leu Arg Gln Thr Leu Arg Gly Ala His Val Glu 
            500                 505                 510         


Tyr Phe Leu Asp Glu Ala Gln Gly Arg Arg Leu Leu Ser Ala Val Leu 
        515                 520                 525             


Ala Asp Ser Gly Pro Ala Thr Leu Pro Leu Pro Arg Phe Arg Arg Ile 
    530                 535                 540                 


Leu Gln Arg Ala His Asn Ala Trp Ala Lys Glu Thr Asp Gly Pro Gly 
545                 550                 555                 560 


Leu Pro Glu Pro Ala Asn Arg Met Asp Ile Lys Thr Tyr Pro Ala Leu 
                565                 570                 575     


His Cys Arg Tyr Val Ala Leu Lys His Val Tyr Glu Arg Pro Phe Arg 
            580                 585                 590         


His Trp Leu Glu Gln Arg Asp Ala Ala Ser Leu Asn Arg His Ile Asp 
        595                 600                 605             


Arg Ala Val Asp Arg Gly Thr Lys Ala Ala Arg Asp Leu Asn Ala Gly 
    610                 615                 620                 


Asp Asp Glu Asp Arg Arg Arg Ile Ile Val Ala Arg Ala Ala Ser Leu 
625                 630                 635                 640 


Gly Arg Leu Ala Glu Asp Asp Asn Val Gln Asp Phe Phe Phe Glu Leu 
                645                 650                 655     


Ser Ala Glu Thr Ala Gly Glu Met Arg Val Gln Arg Gly Tyr Ala Ser 
            660                 665                 670         


Asp Ala Glu Ala Ala Arg Glu Gln Ala Gly Tyr Ile Glu Asp Leu Lys 
        675                 680                 685             


Cys Asp Val Leu Ala Leu Thr Phe Ala Asp Tyr Leu Lys Ala Ala Gly 
    690                 695                 700                 


Leu Asp Phe Ile Arg Ile Leu Ala Pro Glu Thr Pro Arg Pro Asp Asn 
705                 710                 715                 720 


Ala Ala Tyr Asn Leu Asp Ala Ile Glu Ala Pro Glu Ile Asp Thr Pro 
                725                 730                 735     


Gly Glu Asp Trp Gln Arg Val Leu Tyr Phe Ile Leu His Leu Val Pro 
            740                 745                 750         


Val Glu Asp Val Gly Arg Leu Leu His Gln Thr Arg Lys Trp Glu Ile 
        755                 760                 765             


Leu Ala Gly Asp Glu Thr Leu Ser Pro Ser Val Arg Asp Arg Leu Arg 
    770                 775                 780                 


Gly Ile Gln Leu Ala Leu Glu Leu Tyr Leu Asp Met His Asp Ala Lys 
785                 790                 795                 800 


Phe Glu Gly Gly Ala Ala Leu Val Gly Thr Gly Ala Phe Lys Asp Leu 
                805                 810                 815     


Phe Glu Thr Ala Arg Ile Phe Asp Asp Ile Phe Pro Ser Gln Pro Gly 
            820                 825                 830         


Ser Ala Gln Thr Ala Asp Asp Glu Arg Arg Val Pro Lys Arg Gly Leu 
        835                 840                 845             


Cys Glu Ile Met Arg Phe Gly His Arg Pro Ala Leu Gln Pro Ile Phe 
    850                 855                 860                 


Ser Arg Tyr Arg Val Thr Glu Arg Glu Val Glu Glu Val Arg Ala Met 
865                 870                 875                 880 


Glu Trp Pro Val Asp Gly Thr Ser Glu Ile Ala Arg Leu Gln Asp Arg 
                885                 890                 895     


Arg Glu Arg Leu His Lys Gly Trp Thr Glu Asn Lys Ser Gly Leu Ser 
            900                 905                 910         


Gly Asp Asp Leu Arg Ala Tyr Val Ala Ala Leu Arg Glu Val Ala Ala 
        915                 920                 925             


His Arg His Leu Ala Ala His Val Thr Leu Thr Asn His Val Arg Leu 
    930                 935                 940                 


His Arg Leu Leu Met Ala Val Leu Gly Arg Leu Val Asp Tyr Ser Gly 
945                 950                 955                 960 


Leu Trp Glu Arg Asp Leu Tyr Phe Val Thr Leu Ala Leu Ile His Arg 
                965                 970                 975     


Ala Gly Arg Arg Pro Ala Asp Val Leu Pro Ala Asp Gly Leu Arg Phe 
            980                 985                 990         


Leu Ala Asn Gly Gln Ile Val Glu  Ala Val Arg Arg Leu  Glu Pro Asp 
        995                 1000                 1005             


Leu Gln  Ser Arg Leu Leu Asp  Cys Leu Gly Asp Ile  Asp Lys Asn 
    1010                 1015                 1020             


Gly Lys  Val Arg Ile Arg Asn  Arg Phe Ala His Phe  Asn Met Leu 
    1025                 1030                 1035             


Gln Pro  Gly Asn Leu Pro Val  Asp Leu Thr Arg Cys  Val Asn Asp 
    1040                 1045                 1050             


Ala Arg  Glu Leu Met Ala Tyr  Asp Arg Lys Leu Arg  Asn Ala Val 
    1055                 1060                 1065             


Thr Gln  Ser Val Lys Glu Leu  Leu Ala Arg Glu Gly  Leu Met Leu 
    1070                 1075                 1080             


Gly Trp  Ala Met Gly Ala Asp  His Arg Leu Ser Ala  Ala Thr Leu 
    1085                 1090                 1095             


Ala Thr  Arg Gln Ala Gln His  Leu Gly Lys Thr Arg  Arg Gly Glu 
    1100                 1105                 1110             


Lys Gly  Trp His Glu Arg Lys  Leu Arg Pro Ile Pro  Ile Leu Glu 
    1115                 1120                 1125             


Asp Leu  His Gly Arg Arg Phe  Val Asp Met Ala Ala  Ala Leu Phe 
    1130                 1135                 1140             


Gly Gly  Thr Arg Leu Glu Pro  Glu Arg Ser Leu Leu  Asp His Pro 
    1145                 1150                 1155             


Leu Asp  Arg Ile Glu Trp Asn  Pro Thr Pro Lys Asn  Arg Tyr Gly 
    1160                 1165                 1170             


Ser Arg  Pro Thr Ser Gly Gln  Gly Arg Arg Asn Val  Val Pro Arg 
    1175                 1180                 1185             


<210>  633
<211>  1107
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  633

Met Arg Val Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Val Tyr Ser Gly 
            20                  25                  30          


Gln Ala Ile Ser Asn Glu Thr Asn Asn Ile Leu Pro Glu Lys Lys Arg 
        35                  40                  45              


Gln Ser Phe Asp Leu Ser Ile Glu Asn Lys Thr Leu Lys Arg Arg Asp 
    50                  55                  60                  


Asp Val Asp Lys Thr Lys Lys Asp Lys Tyr Asp Ile Val Arg Lys Ile 
65                  70                  75                  80  


Ile Lys Tyr Gly Glu Leu Pro Gln Ser Ile Ser Glu Val Asp Val Leu 
                85                  90                  95      


Glu Phe Leu Asn His Lys Phe Gln Glu Pro Val Lys Tyr Trp Lys Gly 
            100                 105                 110         


Asp Lys Glu Glu Ser Phe Asn Leu Thr Met Leu Ile Leu Glu Ala Val 
        115                 120                 125             


Lys Thr Gln Asp Lys Gln Lys Leu Gln Pro Tyr Asn Glu Trp Lys Lys 
    130                 135                 140                 


Trp Tyr Val Thr Thr Lys Ser Asp Leu Leu Lys Lys Ser Ile Asp Asn 
145                 150                 155                 160 


Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg Lys Lys Ala Leu 
                165                 170                 175     


Leu Ala Trp Glu Thr Glu Phe Thr Thr Ser Gly Asn Ile Asp Leu Thr 
            180                 185                 190         


His Tyr His Lys Val Tyr Met Thr Asp Val Leu Cys Lys Met Leu Gln 
        195                 200                 205             


Glu Val Lys Pro Leu Thr Asp Glu Arg Gly Arg Ile Asn Ser Asn Ala 
    210                 215                 220                 


Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Asn His Gln Pro Ala Met 
225                 230                 235                 240 


Phe Gly Thr Arg Glu Ala Pro Asn Asp Ala Asn Arg Ala Asp Asn Gln 
                245                 250                 255     


Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu Glu His Tyr Phe 
            260                 265                 270         


Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Thr Asp Asp Ile Ser His 
        275                 280                 285             


Tyr Leu Lys Ala Gln Thr Leu Lys Thr Thr Ile Glu Lys Gln Leu Val 
    290                 295                 300                 


Asn Ala Ile Arg Ser Asn Ile Ile Gln Gln Gly Lys Thr Asn His His 
305                 310                 315                 320 


Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile Arg Ile Lys Thr 
                325                 330                 335     


Asn Glu Ala Phe Val Leu Asn Leu Ile Gly Thr Cys Ala Phe Ala Ala 
            340                 345                 350         


Asn Asn Ile Arg Asn Met Val Asp Asn Glu Gln Thr Ser Asp Ile Leu 
        355                 360                 365             


Gly Lys Gly Asp Phe Ser Lys Ser Leu Leu Lys Asp Ser Ala Ser Thr 
    370                 375                 380                 


Gln Leu Tyr Ser Phe Phe Phe Glu Glu Asn Leu Ser Thr Asn Lys Val 
385                 390                 395                 400 


Glu Lys Glu Thr Gln Leu Trp Ala Ile Arg Gly Ala Val Gln Gln Ile 
                405                 410                 415     


Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu Lys Thr Val Phe 
            420                 425                 430         


Asn Ile Ser Asn Phe Glu Asn Pro Thr Thr Thr Asp Pro Lys Gln Gln 
        435                 440                 445             


Thr Asn Tyr Ala Asp Thr Ile Tyr Lys Ala Arg Phe Ile Asn Glu Leu 
    450                 455                 460                 


Glu Lys Ile Pro Glu Ala Phe Ala Gln Gln Leu Lys Thr Gly Gly Ala 
465                 470                 475                 480 


Leu Ser Tyr Tyr Thr Leu Glu Asn Leu Lys Thr Leu Leu Thr Thr Phe 
                485                 490                 495     


Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala Pro Gly Phe Lys 
            500                 505                 510         


Lys Val Phe Asn Gly Gly Ile Asn Tyr Gln Asn Ala Lys Gln Asp Glu 
        515                 520                 525             


Ser Phe Tyr Glu Leu Met Leu Glu Arg Tyr Leu Arg Lys Glu Asn Phe 
    530                 535                 540                 


Ala Glu Glu Ala Tyr Asn Ala Arg Tyr Phe Leu Leu Lys Leu Ile Tyr 
545                 550                 555                 560 


Asn Asn Leu Phe Leu Pro Lys Phe Thr Thr Tyr Arg Lys Ala Phe Ala 
                565                 570                 575     


Asp Ser Val Gly Phe Val Gln Leu Gln Asn Arg Lys Gln Ala Glu Lys 
            580                 585                 590         


Val Asn Pro Lys Lys Lys Glu Ala Tyr Ala Phe Glu Ala Val Arg Pro 
        595                 600                 605             


Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala Tyr Val Gln Ser 
    610                 615                 620                 


Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys Ala Thr Asp Glu 
625                 630                 635                 640 


Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val Phe Ile Lys Gly 
                645                 650                 655     


Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe Val Gln Val Pro 
            660                 665                 670         


Gln Gln Gln Leu Thr Thr Thr Asp Ser Asn Gln Gln Lys Ala Asp Lys 
        675                 680                 685             


Leu Asn Gly Leu Glu Ala Ser Ile Thr Ala Asp Cys Lys Leu Thr Pro 
    690                 695                 700                 


Gln Tyr Ala Lys Ala Asp Asp Ala Thr His Ile Ala Phe Tyr Val Phe 
705                 710                 715                 720 


Cys Lys Leu Leu Asp Ala Ala His Leu Ser Asn Leu Arg Asn Glu Leu 
                725                 730                 735     


Ile Lys Phe Arg Gly Ser Val Asn Glu Phe Lys Phe His His Leu Leu 
            740                 745                 750         


Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val Val Pro Thr Asp 
        755                 760                 765             


Tyr Arg Asp Leu Tyr Thr Asn Glu Ala Asp Cys Leu Ala Arg Leu Ser 
    770                 775                 780                 


Pro Phe Ile Glu Gln Gly Ala Asp Ile Lys Asn Trp Ser Asp Leu Tyr 
785                 790                 795                 800 


Val Gln Thr Asp Lys Gln Thr Pro Val Val His Ala Gly Ile Glu Leu 
                805                 810                 815     


Ser Val Lys Tyr Gly Thr Thr Ala Leu Leu Glu Gln Leu Ile Ala Arg 
            820                 825                 830         


Asn Pro Lys Phe Arg Ile Met Glu Asp Asn Phe Thr Lys Trp Ser Asn 
        835                 840                 845             


Gln Lys Lys Glu Ile Glu Glu Lys Val Asn Ile His Thr Lys Leu His 
    850                 855                 860                 


Lys Glu Trp Val Glu Ala Lys Glu Lys Asp Asp Lys Glu Arg Thr Asp 
865                 870                 875                 880 


Arg Val Lys Ser Lys Thr Asn Phe Ala Arg Lys Phe Val Ser Lys Asn 
                885                 890                 895     


Glu Val Asp Tyr Ile Asn Asn Cys Ile Glu Ile Asn Asn Tyr Asn Trp 
            900                 905                 910         


Leu Asp Asn Lys Leu His Phe Val His Leu Asn His Leu His His Leu 
        915                 920                 925             


Thr Ile Glu Ile Leu Gly Arg Met Ala Gly Phe Val Ala Leu Trp Glu 
    930                 935                 940                 


Arg Asp Phe Gln Tyr Ile Thr Lys Tyr Thr Ala Ala Lys Glu Gly Thr 
945                 950                 955                 960 


Asp Ala Leu Ser Phe Asp Gly Gly Leu Pro Arg Leu Lys Asp Lys Gln 
                965                 970                 975     


Lys Tyr Tyr Asp Lys Leu Phe Leu Ser Asp Lys Tyr Thr Lys Val Arg 
            980                 985                 990         


Asn His Ile Ala His Phe Asn Tyr  Leu Thr Lys Asp Ala  Ala Asp Phe 
        995                 1000                 1005             


Ser Leu  Ile Asp Leu Ile Asn  Glu Leu Arg Glu Leu  Leu His Tyr 
    1010                 1015                 1020             


Asp Arg  Lys Leu Lys Asn Ala  Val Ser Lys Ala Phe  Ile Lys Leu 
    1025                 1030                 1035             


Phe Glu  Lys His Gly Met Ile  Leu Lys Leu Lys Leu  Asn Asp Gly 
    1040                 1045                 1050             


His Gln  Leu Glu Leu Glu Ser  Ile Glu Pro Lys Lys  Ile Tyr His 
    1055                 1060                 1065             


Leu Gly  Ser Ser Ala Lys Asp  Lys Pro Glu Tyr Gln  Tyr Cys Thr 
    1070                 1075                 1080             


Asn Gln  Val Met Thr Ala Tyr  Cys Asn Met Cys Arg  Ser Leu Leu 
    1085                 1090                 1095             


Glu Met  Lys Lys Glu Gln Ile  Gly Leu 
    1100                 1105         


<210>  634
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  634

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asp Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  635
<211>  1167
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  635

Met Lys Val Thr Lys Val Gly Gly Ile Ser His Lys Lys Tyr Thr Ser 
1               5                   10                  15      


Glu Gly Arg Leu Val Lys Ser Glu Ser Glu Glu Asn Arg Thr Asp Glu 
            20                  25                  30          


Arg Leu Ser Ala Leu Leu Asn Met Arg Leu Asp Met Tyr Ile Lys Asn 
        35                  40                  45              


Pro Ser Asn Thr Glu Thr Lys Glu Asn Lys Lys Arg Ile Gly Lys Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Met Val Tyr Leu Lys Asp Asn Thr Leu 
65                  70                  75                  80  


Ser Leu Lys Asn Gly Lys Lys Glu Asn Ile Asp Arg Glu Tyr Ser Glu 
                85                  90                  95      


Thr Asp Ile Ser Glu Tyr Asp Val Arg Asp Ser Lys Asn Phe Ala Val 
            100                 105                 110         


Leu Lys Lys Ile Tyr Leu Asn Glu Asn Val Asn Ser Glu Glu Leu Glu 
        115                 120                 125             


Val Phe Arg Lys Asp Ile Lys Lys Lys Leu Asn Lys Ile Asn Ser Leu 
    130                 135                 140                 


Lys Tyr Ser Phe Glu Lys Asn Lys Ala Asn Tyr Gln Lys Ile Asn Glu 
145                 150                 155                 160 


Asn Asn Ile Glu Lys Val Glu Gly Lys Ser Lys Arg Asn Ile Ile Tyr 
                165                 170                 175     


Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asp Ala Tyr Val Ser Asn Val 
            180                 185                 190         


Lys Glu Ala Phe Asp Lys Leu Tyr Lys Glu Glu Asp Ile Ala Lys Leu 
        195                 200                 205             


Val Leu Lys Ile Glu Asn Leu Thr Lys Leu Glu Lys Ser Lys Ile Arg 
    210                 215                 220                 


Glu Phe Tyr His Glu Ile Ile Gly Arg Lys Asn Asp Lys Glu Asn Phe 
225                 230                 235                 240 


Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Met Lys Glu 
                245                 250                 255     


Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser Gln Val 
            260                 265                 270         


Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Glu Asn Val 
        275                 280                 285             


Lys Tyr Val Phe Cys His Phe Val Glu Ile Glu Met Ser Lys Leu Leu 
    290                 295                 300                 


Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp Lys Val 
305                 310                 315                 320 


Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu Asn Lys 
                325                 330                 335     


Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys Tyr Asn 
            340                 345                 350         


Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile Ala Arg 
        355                 360                 365             


Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val Ser Ser 
    370                 375                 380                 


Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn Lys Asp 
385                 390                 395                 400 


Asp Ile Thr Gly Lys Met Arg Gly Lys Thr Arg Ile Glu Ser Lys Thr 
                405                 410                 415     


Gly Glu Glu Lys Tyr Ile Pro Gly Glu Val Asp Gln Ile Tyr Tyr Glu 
            420                 425                 430         


Asn Lys Gln Asn Glu Val Lys Asn Lys Leu Lys Met Phe Tyr Gly Tyr 
        435                 440                 445             


Asp Phe Asp Met Asp Asn Lys Lys Glu Ile Glu Asp Phe Phe Ala Asn 
    450                 455                 460                 


Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe Asn 
465                 470                 475                 480 


Leu Asp Leu Asp Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Val Pro 
                485                 490                 495     


Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys Lys 
            500                 505                 510         


Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe Arg 
        515                 520                 525             


Tyr Leu Glu Lys Asp Arg Ile Leu Asp Tyr Leu Arg Ser Thr Arg Phe 
    530                 535                 540                 


Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys Leu 
545                 550                 555                 560 


Tyr Asp Arg Ile Asp Asp Leu Lys Ile Ser Leu Asn Ile Tyr Trp Lys 
                565                 570                 575     


Thr Pro Lys Thr Asn Asp Asp Ile Lys Thr Lys Glu Ile Thr Asp Ala 
            580                 585                 590         


Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Lys Phe Leu Asp Tyr 
        595                 600                 605             


Phe Met Ser Arg Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Val Ile 
    610                 615                 620                 


Lys Leu Asn Lys Asn Asn Lys Lys Asn Val Lys Thr Gly Phe Tyr Lys 
625                 630                 635                 640 


Leu Gln Lys Phe Glu Asn Leu Glu Ala Arg Ser Pro Lys Glu Tyr Leu 
                645                 650                 655     


Ala Lys Val Gln Ser Leu Tyr Ile Ile Asn Val Ala Asn Gln Asp Glu 
            660                 665                 670         


Glu Glu Lys Asn Thr Tyr Ile Asp Phe Ile Gln Lys Val Phe Leu Lys 
        675                 680                 685             


Gly Phe Ile Thr Tyr Leu Ala Asn Asn Arg Arg Leu Ser Leu Met Tyr 
    690                 695                 700                 


Ile Gly Ser Asp Glu Glu Val Asn Asn Ser Leu Ala Glu Lys Lys Gln 
705                 710                 715                 720 


Glu Phe Asp Lys Phe Trp Arg Lys Tyr Glu Glu Asn Asn Asp Ile Glu 
                725                 730                 735     


Ile Pro Asp Glu Ile Asn Glu Phe Leu Lys Glu Ile Lys Leu Gly Lys 
            740                 745                 750         


Ile Leu Lys Asn Ser Ala Lys Leu Asn Ile Phe Tyr Leu Ile Leu Lys 
        755                 760                 765             


Leu Leu Asn Asn Lys Glu Phe Thr Asn Leu Lys Gly Asn Leu Glu Lys 
    770                 775                 780                 


Tyr His Ser Ala Asn Glu Val Asn Ile Phe Ser Asp Glu Leu Glu Leu 
785                 790                 795                 800 


Ile Asn Phe Leu Asn Leu Asp Asn Asn Lys Val Lys Glu Asp Phe Glu 
                805                 810                 815     


Phe Glu Ala Asp Glu Ile Gly Lys Phe Leu Asn Phe Asn Gly Asn Lys 
            820                 825                 830         


Ile Lys Asn Arg Glu Glu Leu Lys Lys Phe Asp Thr Thr Lys Met Tyr 
        835                 840                 845             


Phe Tyr Lys Glu Asn Ile Ile Lys Tyr Arg Ala Tyr Tyr Asn Ile Lys 
    850                 855                 860                 


Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala Gly 
865                 870                 875                 880 


Tyr Lys Ile Ser Ile Glu Glu Leu Lys Lys Tyr Ser Asn Lys Lys Asn 
                885                 890                 895     


Glu Ile Glu Lys Asn His Lys Met Gln Glu Asn Leu His Arg Lys Tyr 
            900                 905                 910         


Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Glu Ser 
        915                 920                 925             


Tyr Lys Gln Ala Ile Lys Asn Ile Glu Glu Tyr Thr His Leu Lys Asn 
    930                 935                 940                 


Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu Arg 
945                 950                 955                 960 


Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp Leu 
                965                 970                 975     


Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu Glu 
            980                 985                 990         


Ile Phe Asn Phe Glu Asn Lys Lys  Asn Met Lys Tyr Lys  Ser Gly Gln 
        995                 1000                 1005             


Ile Val  Glu Lys Tyr Ile Lys  Phe Tyr Lys Glu Leu  His Gln Asn 
    1010                 1015                 1020             


Asp Glu  Val Lys Ile Asn Lys  Tyr Ser Ser Ala Asn  Ile Lys Val 
    1025                 1030                 1035             


Leu Lys  Gln Glu Lys Lys Asp  Leu Tyr Ile Arg Asn  Tyr Ile Ala 
    1040                 1045                 1050             


His Phe  Asn Tyr Ile Pro His  Ala Glu Ile Ser Leu  Leu Glu Val 
    1055                 1060                 1065             


Leu Glu  Asn Leu Arg Lys Leu  Leu Ser Tyr Asp Arg  Lys Leu Lys 
    1070                 1075                 1080             


Asn Ala  Val Met Lys Ser Val  Val Asp Ile Leu Lys  Glu Tyr Gly 
    1085                 1090                 1095             


Phe Val  Val Lys Phe Lys Ile  Gly Ala Asp Lys Lys  Ile Glu Ile 
    1100                 1105                 1110             


Gln Ser  Leu Lys Ser Glu Glu  Ile Val His Leu Lys  Lys Leu Lys 
    1115                 1120                 1125             


Leu Lys  Asp Asn Asp Lys Lys  Lys Glu Pro Ile Lys  Thr Tyr Arg 
    1130                 1135                 1140             


Asn Ser  Lys Glu Leu Cys Lys  Leu Val Lys Val Met  Phe Glu Tyr 
    1145                 1150                 1155             


Lys Met  Glu Glu Lys Ser Ser  Glu Lys 
    1160                 1165         


<210>  636
<211>  967
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  636

Leu Leu Arg Met Lys Arg Glu Lys Asn Ile Thr Ile Met Lys Ile Ser 
1               5                   10                  15      


Lys Val Asn His Arg Arg Thr Ala Val Ala Leu Asn Gly Asp Lys Ser 
            20                  25                  30          


Glu Leu Gly Gly Ile Leu Tyr Glu Ala Pro Val Gln Lys Asp Lys Asn 
        35                  40                  45              


Gly Asn Tyr Asn Asp Val Ile Ala Glu Thr Gly Lys Val Val Asn Glu 
    50                  55                  60                  


Ala Leu Asp Lys Lys Ser Arg Leu Tyr Thr Pro Phe Asn Asn Gln Lys 
65                  70                  75                  80  


Val Ile Ile Asp Lys Asn Leu Gln Arg Tyr Ala Asn Asn Leu Lys Arg 
                85                  90                  95      


Cys Tyr Ile Asn Phe Val Lys Gln Tyr Val Asn Asn Lys Ser Phe Asn 
            100                 105                 110         


Tyr Lys Ala Met Gln Phe Ile Pro Asp Ile Gln Asn Pro Lys Thr Asn 
        115                 120                 125             


Asp Ala Val Asn Tyr Arg Thr Asp Arg Asp Asn Val Tyr Asn Lys Asn 
    130                 135                 140                 


Lys Tyr Tyr Asp Lys Gln Thr Lys Ser Lys Ser Lys Lys Phe Ile Tyr 
145                 150                 155                 160 


Glu Lys Ile Val Ile Pro Gln Asn Glu Gln Asn Ile Val Ile Ser Ala 
                165                 170                 175     


Leu Val Asn Cys Ser Leu Arg Lys Ser Leu Arg Lys Asp Val Ser Tyr 
            180                 185                 190         


Lys Thr Lys Ser Gly Glu Ile Lys Thr Tyr Asn Leu Pro Glu Leu Val 
        195                 200                 205             


Lys Lys Ser Met Arg Phe Tyr Cys Leu Glu Gly Gln Arg Glu Pro Asp 
    210                 215                 220                 


Glu Lys Glu Lys Tyr Glu Met Tyr Ile Leu Phe Ser Tyr Met Lys Glu 
225                 230                 235                 240 


Asp Lys Arg Thr Lys Asn Thr Asp Leu Leu Val Lys Ser Ile Ser Asn 
                245                 250                 255     


Gln Asn Thr Lys Val Lys Val Glu Asp Ile Asp Gly Asn Lys Leu Leu 
            260                 265                 270         


Lys Leu Ser Ile Ala Asp Thr Lys Lys Lys Pro Leu Trp Glu Tyr Leu 
        275                 280                 285             


Ile Lys Tyr Ala Asp Ser Ser Arg Gln Arg Glu Leu Met Tyr Asp Ile 
    290                 295                 300                 


Arg Lys Lys Ile Ile Leu Tyr Val Ala Gly Ile Glu Glu Tyr Glu Asn 
305                 310                 315                 320 


Ile Lys Glu Asp Ser Gly Leu Ser Lys Val Ser Trp Ser Lys Tyr Asn 
                325                 330                 335     


Ile Ser Asp Asn Lys Met Phe Phe Asp Ile Asn Ser Cys Thr Asp Lys 
            340                 345                 350         


Arg Lys Gln Asn Leu Glu Ile Lys Ile Arg Glu Ala Asn Ile Glu His 
        355                 360                 365             


Tyr Arg Asn Ala Ser Ser Lys Leu Cys Asp Asp Glu Ser Ile Phe Trp 
    370                 375                 380                 


Phe Gln His Phe Glu Gly Val Ile Glu Thr Leu Phe Ser Lys Lys Ser 
385                 390                 395                 400 


Lys Ile Ser Glu Glu Arg Leu Gly Cys Ala Tyr Ile Cys Asp Tyr Leu 
                405                 410                 415     


Trp Lys Asp Phe Leu Ser Tyr Leu Ala Ala Lys Tyr Ile Asp Leu Gly 
            420                 425                 430         


Lys Gly Val Tyr His Phe Thr Met Lys Asp Lys Leu Asp Met Leu Asn 
        435                 440                 445             


Lys Asn Glu Ala Val Thr Asp Leu Arg Phe Gly Ile Val Ser Glu Lys 
    450                 455                 460                 


Tyr Glu Lys Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys Ala Glu 
465                 470                 475                 480 


Glu Glu Leu Asp Arg Asn Ile Ala Ala Tyr Val Thr Phe Ala Ala Asp 
                485                 490                 495     


Ile Phe Ala Lys Ser Val Ile Lys Ser Asp Tyr Arg Thr Lys Lys Asp 
            500                 505                 510         


Asn Asn Ser Asp Val Leu Gln Tyr Ser Asp Lys Glu Phe Arg Asn Ser 
        515                 520                 525             


Glu Val Ile Arg Asp Asn Ala Glu Lys Asn Ile Leu Gln Tyr Trp Gly 
    530                 535                 540                 


Gly Tyr Ser Arg Trp Cys Thr Glu Asn Ser Lys Leu Pro Glu Asn Asn 
545                 550                 555                 560 


Lys Val Ser Asp Phe Gly Lys Leu Asp Val Ser Asp Leu Cys Ile Asp 
                565                 570                 575     


Ile Lys Lys His Leu Ala Gly Ile Arg Asn Ser Ser Val His Tyr Thr 
            580                 585                 590         


Thr Asn Ile Lys Asn Glu Ser Ala Ala Asp Gly Ser Asn Val Lys Ile 
        595                 600                 605             


Leu Phe Glu Lys Asp Leu Ala Asp Ile Asn Ile Ile Tyr Ala Asp Lys 
    610                 615                 620                 


Tyr Tyr Ser Asn Asn Val Trp Met Phe Tyr Ser Leu Glu Asp Ile Asn 
625                 630                 635                 640 


Lys Leu Ile Ala Phe Leu Tyr Lys Glu Lys Arg Val Ile Arg Gln Val 
                645                 650                 655     


Gln Ile Pro Ser Phe Ser Arg Ile Leu Lys Arg Lys Ala Met Gln Asp 
            660                 665                 670         


Val Ile Asn Glu Ile Phe Lys Asp Asp Phe Asp Glu Asn Ile Val Asn 
        675                 680                 685             


Pro Glu Leu Lys Glu Lys Tyr Arg Asn Ser Leu Tyr Phe Met Leu Lys 
    690                 695                 700                 


Glu Ile Tyr Tyr Asn Ala Phe Ile Ile Gln Pro Glu Leu Lys Glu Lys 
705                 710                 715                 720 


Phe Lys Asp Lys Ile Lys Thr Met Lys Ser Glu Leu Tyr Asn Lys Leu 
                725                 730                 735     


Lys Thr Ile Asp Lys Lys Glu Tyr Lys Ala Leu Tyr Cys Met Leu Ser 
            740                 745                 750         


Asn Glu Glu Ser Ala Leu Lys Asn Phe Ala Asp Arg Ile Tyr Ser Val 
        755                 760                 765             


Asp Gly Asp Asn Val Ser Phe Ala Asp Ile Cys Lys Ile Leu Met Thr 
    770                 775                 780                 


Asp Tyr Asn Met Gln Asn Gln Glu Lys Lys Asn Ile Glu Ser Met Glu 
785                 790                 795                 800 


Gln Lys Lys Lys Asn Lys Gly Lys Asp Glu Asn Tyr Lys His Phe Pro 
                805                 810                 815     


Leu Leu Leu His Lys Val Leu Lys Glu Leu Phe Ile Glu Tyr Leu Lys 
            820                 825                 830         


Gln Thr His Glu Leu Glu Phe Leu Arg Asn Asn Ile Cys Ile Lys Ser 
        835                 840                 845             


Asp Val Thr Met Glu Ser Phe Glu Ser Gln Ile Lys Gly Val Glu Ile 
    850                 855                 860                 


Tyr Lys Asp Leu Lys Glu Lys Ile Asp Lys Asn Asn Ser Leu Leu Asp 
865                 870                 875                 880 


Trp Tyr Val Ile Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu 
                885                 890                 895     


Ile Gly Asn Ile Lys Asn Tyr Ile Gln Phe Ala Thr Asn Ile Asp Lys 
            900                 905                 910         


Arg Ala Glu Ser Val Lys Asn Leu Thr Glu Ser Gly Met Val Lys Arg 
        915                 920                 925             


Ile Gln Tyr Tyr Asp Asp Ile Val Arg Thr Leu Glu Phe Ser Ala Gln 
    930                 935                 940                 


Tyr Ile Gly Lys Ile Ser Asn Asn Ile Asn Asp Tyr Phe Asn Ser Glu 
945                 950                 955                 960 


Asp Glu Tyr Val Ser Phe Leu 
                965         


<210>  637
<211>  1425
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  637

Met Lys Leu Ser Lys Val Asp Arg Ile Arg Val Ala Val Gly Lys Thr 
1               5                   10                  15      


Gly Lys Thr Glu Asn Gly Asn Ser Gln Gly Arg Gly Val Leu Tyr Arg 
            20                  25                  30          


Ser Pro Lys Gly Asn Lys Thr Val Ala Val Asp Ala Val Val Glu Glu 
        35                  40                  45              


Arg Ile Arg Asn Ala Asn Arg Leu Tyr Ser Ala Phe Phe Arg Cys Ala 
    50                  55                  60                  


Tyr Pro Glu Glu Pro Glu Arg His Phe Glu Glu Ile Ile Lys Arg Met 
65                  70                  75                  80  


Ala Thr Gly Lys Lys Ser Gly Ala Gln Ile Leu Lys Glu Tyr Ile Gly 
                85                  90                  95      


Tyr Glu Gly Gln Lys Asn Arg Lys Pro Tyr Thr Phe Tyr Val Asn Lys 
            100                 105                 110         


Cys Ala Tyr Arg Pro Ala Gly Lys Glu Leu Gly Gln Val Leu Arg Leu 
        115                 120                 125             


Phe Val Lys Glu Arg Leu Gly Gln Asn Trp Gln Asn Pro Glu Ala Ala 
    130                 135                 140                 


Glu Ala Ala Val Ala Leu Leu Thr Cys Leu Cys Glu Gly Lys Thr Asn 
145                 150                 155                 160 


Arg Tyr Thr Glu Asn Thr Ala Asp Gly Pro Val Leu Thr Glu Leu Ser 
                165                 170                 175     


Glu Gln Thr Val Thr Gln Leu Glu Gln Val Ser Arg Leu Gly Gly Ser 
            180                 185                 190         


Ile Leu Val Pro Lys Thr Glu Arg Leu Glu Thr Ile Val Thr Val Ile 
        195                 200                 205             


Leu Arg Leu Thr Ala Glu Gln Cys Asn Thr Ser Leu Tyr Val Asn Gly 
    210                 215                 220                 


Gly Thr Lys Glu Ala Gln Asp Ala Asp Leu Glu Lys Gln Ile Ala Leu 
225                 230                 235                 240 


Leu Lys Ser Leu Gln Thr Lys Pro Leu Leu Leu Lys Glu Arg Phe Asp 
                245                 250                 255     


Lys Val Thr Lys Gln Thr Ile Arg Asp Glu Gln Lys Leu Ser Glu Phe 
            260                 265                 270         


Ser Tyr Lys Asp Ala Thr Lys Glu Arg Met Glu Ala Val Val Val Arg 
        275                 280                 285             


Met Arg Lys Thr Leu Lys Lys Gly Ala Ser Arg Glu Val Ala Val Glu 
    290                 295                 300                 


Leu Leu Gln Ala Leu Ala Gln Tyr Asp Gly Lys Thr Trp Asp Gly Trp 
305                 310                 315                 320 


Leu Thr Gln Met Leu Glu Thr Glu Ala Ser Lys Lys Lys Leu Lys Asp 
                325                 330                 335     


Phe Ile Leu Ala Val Asn Lys Asp Phe His His Phe His Val Ile Lys 
            340                 345                 350         


Ser Val Lys Asn Thr Ala Val Ala Val Ser His Ser Glu Asp Asn Thr 
        355                 360                 365             


Leu Gln Leu Ser Gly Ala Lys Lys Lys Thr Lys Gly Ala Met Gln Asp 
    370                 375                 380                 


Ala Leu Phe Ala Tyr Ala Gln Ser Glu Glu Ser Ser Asp Glu Thr Leu 
385                 390                 395                 400 


His Arg Ile Lys Arg Ile Leu Phe Thr Tyr Val Leu Gly Gly Arg Gln 
                405                 410                 415     


Asp Asn Thr Leu Arg Leu Thr Glu Lys Thr His Leu Ala Lys Glu Leu 
            420                 425                 430         


Leu Trp Lys Phe Arg Gly Thr Gly Ala Gly Leu Phe Asp Ala Asp Phe 
        435                 440                 445             


Val Pro Glu Glu Glu Arg Ala Gly Glu Ser Gly Arg Lys Ala Gly Ser 
    450                 455                 460                 


Tyr Thr Asp Leu Gly Cys Leu Phe Ala Glu Asp Asp Gly Ile Arg Asn 
465                 470                 475                 480 


Gln Arg Arg Ile Ala Asp Arg Ile Asn Tyr Val Asn Tyr Gly Asn Tyr 
                485                 490                 495     


Leu Arg Met Arg Lys Ala Ala Glu Asp Glu Phe Thr Leu Phe Trp Cys 
            500                 505                 510         


Ala Tyr Ile Lys Asp Tyr Ile Glu Glu Asn Tyr Val Thr Lys Ile Arg 
        515                 520                 525             


Glu Ala Lys Arg Thr Gly Gly Lys Arg Arg Leu Lys Glu Thr Asp Cys 
    530                 535                 540                 


Glu Ala Glu Arg Met Met Glu Lys Cys Trp His Asp Ile Ile Arg Tyr 
545                 550                 555                 560 


Ile Cys Gly Lys Tyr Ile His Ile Gly Lys Ala Val Tyr His Phe Ala 
                565                 570                 575     


Ile Pro Glu Asp Leu Leu Ala Asn Pro Gly Glu Val Arg Ser Phe Gly 
            580                 585                 590         


Asp Val His Ala Lys Tyr Ala Asp Gly Ile Thr Ser Phe Asp Tyr Glu 
        595                 600                 605             


Asp Ile Lys Ala Glu Glu Asn Leu Gln Lys Ser Ile Phe Asn Val Leu 
    610                 615                 620                 


Val Ser Ala Val Ala Asn Tyr Ser Arg Ser Val Val Asp Leu Ser Ser 
625                 630                 635                 640 


Glu Arg Ala Glu Glu Leu Arg Arg Leu Pro Gly Asn Glu Arg Leu Asn 
                645                 650                 655     


Glu Asp Val Leu Met Met Lys Glu Thr His Leu Lys Glu Leu Leu Leu 
            660                 665                 670         


Pro Asp Ala Lys Lys Arg Leu Leu Arg Tyr Phe Gly Gly Tyr Ser Ala 
        675                 680                 685             


Cys Glu Gly Leu Ser Gly Val Thr Ser Glu Glu Leu Ala Trp Glu Met 
    690                 695                 700                 


Arg Thr Val Leu Ser Thr Leu Arg Asn Glu Ser Phe His Tyr Thr Phe 
705                 710                 715                 720 


Gly Lys Lys Lys Lys Leu Asp Tyr Lys Val Ala Lys Gln Leu Trp Met 
                725                 730                 735     


Gln Ala Ile Arg Ala Asn Arg Gln Leu Ile Leu Asp Lys Tyr Tyr Ser 
            740                 745                 750         


Asn Asn Thr Cys Arg Tyr Tyr Ser Pro Asn Ser Ile Lys Ala Leu Ile 
        755                 760                 765             


Glu Gln Gly Tyr Arg Ser Tyr Glu Glu Arg Glu Ala Gln Ile Pro Ala 
    770                 775                 780                 


Phe Lys Thr Val Trp Lys Lys Ala Glu Leu Ala Lys Tyr Leu Ala Asp 
785                 790                 795                 800 


Lys Lys Val Met Pro Ala Glu Ile Ser Gly Glu Glu Lys Glu Arg Val 
                805                 810                 815     


Ile Phe Gln Gly Ala Phe Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg 
            820                 825                 830         


Glu Phe Thr Val Gly Asn Thr Ala Ala Lys Tyr Phe Phe Asp Ala Val 
        835                 840                 845             


Glu Arg Tyr Cys Lys Glu Asn Glu Thr Gly Pro Tyr Lys Asn Pro Ala 
    850                 855                 860                 


Lys Ser Phe Asn Asp Tyr Val Asn Gly Ala Phe Asn Asn Lys Gly Val 
865                 870                 875                 880 


Lys Val Gln Lys Gly Leu Ser Asp Leu Tyr Arg Glu Gly Lys Ile Thr 
                885                 890                 895     


Phe Gly Val Val Cys Gln Thr Ile Met Ala Glu Tyr Thr Gln Gln Asn 
            900                 905                 910         


Glu Lys Ser Glu Gly Glu Ala Ile Tyr Gln His Phe Lys Met Leu Phe 
        915                 920                 925             


Pro Leu Cys Met Arg Lys Gly Phe Gln Lys Tyr Val Glu Glu Lys His 
    930                 935                 940                 


Lys Glu Leu Leu Gln Pro Val Ile Arg Glu Met Gly Ser Arg Glu Asp 
945                 950                 955                 960 


Phe Leu Thr Asn Ile His Ile Gly Cys Phe Asp Asp Phe Cys Arg Glu 
                965                 970                 975     


Asp Gly Met Tyr Glu Tyr Asp Trp Phe Val Val Ala His Leu Ile His 
            980                 985                 990         


Pro Lys Arg Leu Asn Glu Leu Val  Gly Asn Leu Lys Asp  Tyr Met Gln 
        995                 1000                 1005             


Phe Lys  Gln Asp Ile Leu Arg  Arg Ala Asp Tyr Val  Glu Gln Phe 
    1010                 1015                 1020             


Thr Lys  Glu Glu Leu Ala Ala  Met Lys Ala Arg Thr  Glu Glu Lys 
    1025                 1030                 1035             


Leu Gln  Lys Ile Ser Gly Ile  Leu Arg Val Ala Glu  Phe Val Arg 
    1040                 1045                 1050             


Gly Ile  Ala Gly Arg Val Ser  Asn Thr Phe Ser Asp  Tyr Tyr Glu 
    1055                 1060                 1065             


Ser Glu  Glu Ala Tyr Ala Ser  Tyr Leu Glu Gln Tyr  Ile Glu Phe 
    1070                 1075                 1080             


Pro Arg  Ile Lys Gly Ser Thr  Val Phe Glu Ser Phe  Arg Asp Phe 
    1085                 1090                 1095             


Cys Val  Asn Thr Leu Pro Gly  Gly Ala Val Met Asp  Val Tyr Met 
    1100                 1105                 1110             


Asp Glu  Lys Asn Pro Arg Ile  Leu Arg Asn Val Glu  Val Ala Arg 
    1115                 1120                 1125             


Met Tyr  Ala Gly Gly Asp Ile  Gly Leu Arg Thr Arg  Lys Lys Val 
    1130                 1135                 1140             


Thr Ala  Glu Glu Leu Lys Arg  Tyr Tyr Gln Asn Glu  Ala Glu Val 
    1145                 1150                 1155             


Ala Ala  Leu Leu Lys Ala Gly  Leu Cys Ala Thr Ala  Glu Asp Gln 
    1160                 1165                 1170             


Lys Arg  Val Lys Ala Gln Gln  Glu Leu Arg Asn Arg  Ile Thr Leu 
    1175                 1180                 1185             


Thr Asp  Val Thr Glu Ile Gln  Glu Val Ile Asn Asp  Leu Leu Ser 
    1190                 1195                 1200             


Gln Leu  Val Thr Phe Ser Tyr  Phe Arg Glu Arg Asp  Glu Met Tyr 
    1205                 1210                 1215             


Leu Leu  Leu Gly Phe Tyr Tyr  Met Ala Leu Gln Ser  Asp Gly Asp 
    1220                 1225                 1230             


Trp Gly  Glu Glu Leu Arg Val  Phe Asp Gly Lys Lys  Leu Gln Val 
    1235                 1240                 1245             


Glu Asn  Gly Phe Val Leu Tyr  Gln Leu Leu Ser Ala  Phe Thr Tyr 
    1250                 1255                 1260             


Gly Leu  Asn Met Tyr Ser Glu  Ala Ala Pro Asp Gly  Lys Gly Gly 
    1265                 1270                 1275             


Ser Gln  Ala Gly Lys Ile Gly  Glu Phe Ile Lys Ala  His Pro Asn 
    1280                 1285                 1290             


Ser Trp  Asp Arg Ala Leu Arg  Leu Phe Val Asp Asp  Gly Ala Cys 
    1295                 1300                 1305             


Glu Glu  Val Ser Arg Lys Ala  Arg Asn Tyr Val Asp  His Phe Arg 
    1310                 1315                 1320             


Tyr Tyr  Val Lys Pro Asp Arg  Ser Ile Met Asp Leu  Tyr Ala Val 
    1325                 1330                 1335             


Tyr His  Glu Tyr Phe Phe Asp  Tyr Ser Thr Lys Met  Arg Lys Ser 
    1340                 1345                 1350             


Val Leu  Gln Asn Phe Ala Ser  Ile Leu Glu Arg Tyr  Phe Val Leu 
    1355                 1360                 1365             


Thr Lys  Phe Lys Leu Gly Gly  Glu Arg Gly Ala Gln  Thr Leu Glu 
    1370                 1375                 1380             


Ala Glu  Leu Ser Gly Asp Lys  Phe Thr Tyr Lys Leu  Ser Asp Thr 
    1385                 1390                 1395             


Lys Ala  Lys Pro Val Val Leu  Pro Ala Arg Asn Lys  Glu Phe Leu 
    1400                 1405                 1410             


Glu Asn  Leu Lys Asn Glu Leu  Asn Tyr Arg Gln Glu  
    1415                 1420                 1425 


<210>  638
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  638

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Asp Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Lys Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  639
<211>  1363
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  639

Met Lys Ile Ile Arg Pro Lys Gly Lys Ser Phe Thr Thr Leu Thr Gln 
1               5                   10                  15      


Thr Asp Ala Leu Glu Arg Gly Ile Arg Arg Ala Gly Asp Lys Val Ala 
            20                  25                  30          


His Pro Val Ala Phe Ser Ala Ser Arg Asp Val Ser Ala Asn Gln Leu 
        35                  40                  45              


Pro Glu Tyr Leu Ser Ala Asp Gln Glu Leu Val Leu Arg Gln Leu Val 
    50                  55                  60                  


Ser Gly Leu Asp Lys Val Val Arg Lys Pro Arg Arg Asn Asn Leu Arg 
65                  70                  75                  80  


Asn Phe Gln Ala Asp Ala Tyr Val Asp Arg Thr Lys Leu Gly Leu Glu 
                85                  90                  95      


Leu Trp Asn Val Phe Glu Glu Gln Cys Gly Asp Ser Leu Arg Ser Leu 
            100                 105                 110         


Asp Gly Gly Ala Asp Val Leu Ala Asn Leu Ala Arg Ile Trp Arg Trp 
        115                 120                 125             


Lys Val His Pro Tyr Ser Glu Phe Ile Val Asp Met Leu Ser Pro Arg 
    130                 135                 140                 


Ser Asp Lys Asn Ala Glu Val Ile Ala Lys Tyr Gly Asp Lys Glu Leu 
145                 150                 155                 160 


Ser Arg Ser Asp Phe Tyr Gly Arg Trp His Glu Ala Phe Trp Lys Thr 
                165                 170                 175     


Thr Ser Asn Gly Arg Ala Asp Tyr Ser Ala Thr Ala Glu Ala Ile Trp 
            180                 185                 190         


Ala His Leu Phe Gln Glu Glu Ile Lys Ile Thr Lys Glu Gln Arg Asn 
        195                 200                 205             


Arg Lys Asn Thr Thr Asp Trp Pro Ala Lys Gly Leu Ala Gln Ala Lys 
    210                 215                 220                 


Gly Arg Ser Ile Ala Leu Ser Ala His Asp Pro Ala Lys Gly Gly Thr 
225                 230                 235                 240 


Leu Arg Leu Asp Asp Thr Val Asp Glu Ala Val Ile Ala Leu Tyr Phe 
                245                 250                 255     


Ala His Asp Val Val Lys Glu Leu Arg Asp Ala Val Leu Thr Ala Ala 
            260                 265                 270         


Lys Ala Ser Ser Gly Arg Asn Ala Gln Phe Ser Gln Ser Asp Phe Gly 
        275                 280                 285             


Arg Val Leu Tyr Glu His Phe Gly Pro Ile Ile Lys Arg Pro Leu Asp 
    290                 295                 300                 


Glu Ala Leu Asn Arg Ser Leu Trp Arg Leu His Asn Ala Val Arg Gly 
305                 310                 315                 320 


Phe Tyr Gln Glu Leu Ala Arg Ser Glu Gly Tyr Ser Arg Ala Met Arg 
                325                 330                 335     


Asp Pro Val Arg Glu Leu Gly Lys Leu Glu Glu Leu Leu Pro Arg Asp 
            340                 345                 350         


His Gln His Leu Ile Gln Ile Leu Gly Ala Lys Asp Arg Asn Ala Gln 
        355                 360                 365             


Ile Ser Ala Leu Thr Arg Leu Gly Lys Leu Ile Ala His Ala Ser Asp 
    370                 375                 380                 


Leu Pro Ala Gly Thr Gln Asp Val Asn Ala Ala Phe Ala Glu Arg Phe 
385                 390                 395                 400 


His Phe Leu Gln Thr Ser Asp Gly Gln Asn Glu Ile Lys Arg Asn Glu 
                405                 410                 415     


Ala Phe Val Arg Val Trp Arg Thr Ser Ile Ala Leu Ser Leu Arg Thr 
            420                 425                 430         


Leu His Ala Leu Thr Ser Phe Ala His Ile Asp Gly Lys Ser Asp Asp 
        435                 440                 445             


Leu Thr Glu Thr Thr Tyr Ala Ala Gln Ala Ile Lys Arg Tyr Ala Ala 
    450                 455                 460                 


Pro Ala Thr Asp Lys Gly Lys Pro Gln Pro Cys Gln Ser Tyr Gln His 
465                 470                 475                 480 


Gly Ile Glu Leu Ile Phe Gly Ser Lys Thr Ile Pro Ser Leu Gly Gly 
                485                 490                 495     


Gly Ser Arg Ala Thr Thr Leu Leu Leu Thr Tyr Thr Gly Gly Arg Arg 
            500                 505                 510         


Asp Thr Asp Pro Asn Thr Glu Val Leu Trp Ala Phe Leu Arg Leu Ala 
        515                 520                 525             


Ser Glu Ile Arg Lys Arg Ala Tyr His Phe Asn Thr Lys Glu Arg Leu 
    530                 535                 540                 


Leu Glu Leu Ile Lys Ser Cys Pro Leu Lys Ile Thr Asp Gln Leu Val 
545                 550                 555                 560 


Ser Phe Gly Ser Arg Thr Gly Leu Ile Ala Ser Gln Ile Ala Ala Asp 
                565                 570                 575     


Ala Phe Ala Gln Leu Leu Glu Phe Asp Leu Ser Leu Gln Glu Gln Val 
            580                 585                 590         


Ile Leu Asp Glu Phe Arg Arg Leu Asp Val Ser Ala Tyr Val Lys Pro 
        595                 600                 605             


Ser Asp Leu Asp Glu Leu Tyr Ala Glu Phe Ser Arg Val Pro Asp Thr 
    610                 615                 620                 


Ile Gln His Thr Gln Pro Lys Phe Ile Ser Val Leu Arg Arg Ala His 
625                 630                 635                 640 


Ala Ile Cys Gln Gly Asp Glu Gly Lys Pro Pro Val Trp Ala Ala Pro 
                645                 650                 655     


Phe Ala Thr Leu Asp Leu Ala Gly Leu Ser Lys Val Lys Glu Gly Ala 
            660                 665                 670         


Asn His Phe Arg Leu Gly Val Leu Arg Gln Leu Tyr Lys Ser Gly Phe 
        675                 680                 685             


Ala Ala Trp Leu Ser Gln Gln Ser Asn Asn Ala Ala Leu Val Arg Ser 
    690                 695                 700                 


Ala Ile Ala Glu Val Thr Thr Phe Lys Ile Gln Arg Phe Glu Glu Tyr 
705                 710                 715                 720 


His Gly Pro Lys Ser Asp His Arg Arg Val Tyr Ala Met Ala Glu Pro 
                725                 730                 735     


Ile Ala Gln Ser Leu Ala Leu Glu Thr Ala Ala Ser Leu Glu Asp Leu 
            740                 745                 750         


Phe Arg Arg Leu Gln Ser Glu Ala Met Ser Glu Asp Ser Ile Arg Gln 
        755                 760                 765             


Thr Tyr Arg Ala Ser Ala Val Lys Gln Arg Glu Arg Met Gly Gly Val 
    770                 775                 780                 


Gly Glu Phe Arg Leu Asp Leu Phe Ala Arg Leu Phe Ala Leu Tyr Leu 
785                 790                 795                 800 


Glu Gln Thr Asn Leu Asn His Ile Trp Gly Ile Thr Gly Pro Leu Pro 
                805                 810                 815     


Pro Glu Glu Arg Ala Pro Ala Glu Arg Leu Ala Thr Phe Ala Ala Pro 
            820                 825                 830         


Ala Lys Leu Leu Asp Arg Ile Glu Pro Trp His Ser Gln Phe Tyr Val 
        835                 840                 845             


Trp Leu Tyr Leu Ile Pro Ile Asp Glu Val Ala Leu Leu Arg His Gln 
    850                 855                 860                 


Leu Arg Lys Thr Val Ala Leu Glu Ala Lys Ser Gly Ile Gly Ser Gln 
865                 870                 875                 880 


Asp Ile Leu Ser Gln Val Asp Leu Leu Met Gly Leu Tyr Leu Ser Val 
                885                 890                 895     


Tyr Asp Ala Gly Phe Asp Gly Arg Glu His Val Gly Gly Leu Asn Ala 
            900                 905                 910         


Gly Lys Leu Phe Tyr Glu Ser Pro Gln Asp Phe Glu Lys Val Tyr Ser 
        915                 920                 925             


Asp Asp Gln Ser His His Glu Ile Ser Met Pro Gly Thr Arg Arg Gly 
    930                 935                 940                 


Leu Arg Gln Ile Leu Arg Met Asp His Phe Arg Ala Leu Glu Gly Ile 
945                 950                 955                 960 


Phe Glu Lys His Gln Val Thr Thr Asp Glu Val Lys Ala Phe Gln Gln 
                965                 970                 975     


Leu Lys Leu Thr Glu Val Gln Glu Ile Leu Glu Ser Lys Ile Arg Leu 
            980                 985                 990         


Gln Lys Ser Ile Ile Ser Met Ser  Lys Gln Ala Lys Leu  Asp Thr Glu 
        995                 1000                 1005             


Ala Leu  Arg Ser Glu Cys Gln  Lys Tyr Gln Val Ser  Ala Thr Lys 
    1010                 1015                 1020             


Leu Ala  Ile Tyr Asn Phe Gln  Val Lys Ala Ala Arg  Leu Ser Glu 
    1025                 1030                 1035             


His Ala  Arg Leu His Gln Leu  Met Met Arg Val Leu  Gly Arg Leu 
    1040                 1045                 1050             


Ala Asp  Phe Ser Met Met Trp  Glu Arg Asp Arg Gln  Tyr Leu Phe 
    1055                 1060                 1065             


Leu Gly  Leu Leu Tyr Arg Arg  Ile Gly Ala Glu Asn  Phe Ile Leu 
    1070                 1075                 1080             


His Arg  Met Ala Asp Glu Ile  Gly Ile Ala Leu Pro  Ala Asp Ala 
    1085                 1090                 1095             


Gly Leu  Gly Leu Val Ala Asp  Ala Gly Ala Ala Thr  Arg Arg Ser 
    1100                 1105                 1110             


Gly Ala  Ile Ser Asp Met His  Val Gln Ala Gly Phe  Leu Pro Leu 
    1115                 1120                 1125             


Trp Asp  Pro Asp Phe Gly Phe  Val Arg Glu Gly Asp  Gly Ala Glu 
    1130                 1135                 1140             


Leu Thr  Leu Leu Ala Val Gln  Asp Arg Glu Leu Phe  Met Arg Tyr 
    1145                 1150                 1155             


Phe Gly  Lys Leu Pro Glu Glu  Asn Pro Arg Asp Val  Arg Arg Arg 
    1160                 1165                 1170             


Glu Ala  Asn Glu Ala Glu Gly  Phe Ala Arg Pro Ser  Thr Lys Asn 
    1175                 1180                 1185             


Trp Asn  Gly Ser Phe Arg Leu  Pro Lys Arg Arg Ile  Arg Asn Asp 
    1190                 1195                 1200             


Phe Ala  His Phe Asn Val Ile  Ser Gly Lys Arg Arg  Pro Asn Leu 
    1205                 1210                 1215             


Thr Tyr  Leu Met Asn Ala Ile  Arg Ser Leu Met Ser  His Asp Arg 
    1220                 1225                 1230             


Lys Met  Lys Asn Ala Val Ser  Lys Ala Val Ala Glu  Ile Val Ala 
    1235                 1240                 1245             


Glu Glu  Gly Leu Glu Ile Arg  Trp Gln Val Arg Gly  Asp Arg Leu 
    1250                 1255                 1260             


Val Asp  Pro Thr Val Ile Pro  Met Leu Glu Ser His  Leu Thr Met 
    1265                 1270                 1275             


Val Arg  Pro Lys Asp Gly Phe  Asp Pro Arg Phe His  Leu Pro Gln 
    1280                 1285                 1290             


Ala Ser  Val Arg Phe Thr Ser  Met Val Lys Ala Leu  Phe Glu Phe 
    1295                 1300                 1305             


Asp Gln  Gly Gly Tyr Arg Glu  Thr Ile Pro Trp Lys  Glu Gly Lys 
    1310                 1315                 1320             


Lys Ala  Ser Arg Gly Gln Leu  Gly Tyr Pro Lys Glu  Phe Ile Ala 
    1325                 1330                 1335             


Arg Ile  Glu Gln Asp Glu Thr  Ile His Val Pro Arg  Glu Val Leu 
    1340                 1345                 1350             


Ala Gln  Arg Tyr Lys Gly Leu  Glu Gln Lys 
    1355                 1360             


<210>  640
<211>  1384
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  640

Met Gly Asn Leu Phe Gly His Lys Arg Trp Tyr Glu Val Ser Asp Arg 
1               5                   10                  15      


Glu Asn Tyr Lys Ile Lys Arg Lys Val Lys Val Lys Arg Asn Tyr Asp 
            20                  25                  30          


Gly Asn Lys Tyr Ile Leu Asn Ile Asn Glu Asn Asn Asn Lys Glu Lys 
        35                  40                  45              


Ile Asp Asn Asn Glu Phe Ile Glu Glu Leu Val Asn Tyr Lys Lys Asn 
    50                  55                  60                  


Asn Asn Val Leu Arg Glu Phe Lys Arg Lys Phe His Ala Arg Asn Ile 
65                  70                  75                  80  


Leu Phe Lys Leu Lys Gly Asn Lys Arg Ser Ile Glu Asp Ser Asn Asp 
                85                  90                  95      


Phe Leu Lys Thr Glu Glu Val Val Leu Asp Lys Glu Ile Tyr Gly Gln 
            100                 105                 110         


Ser Glu Lys Leu Arg Asn Glu Lys Gly Ile Thr Lys Lys Asp Ile Leu 
        115                 120                 125             


Lys Glu Ile Asn Lys Gln Lys Ile Asp Asn Ser Val Lys Lys Ile Ser 
    130                 135                 140                 


Met Asn Thr Asn Ser Gly Lys Thr Ile Val Ile Asn Phe Ser Asp Lys 
145                 150                 155                 160 


Leu Lys Lys Asp Lys Asp Asp Tyr Gln Ile Thr Leu Asn Ile Ile Ser 
                165                 170                 175     


Glu Asp Glu Leu Glu Arg Lys Arg Lys Ile Tyr Asp Ile Phe Lys Met 
            180                 185                 190         


Ile Asn Met Asp Leu Tyr Gln Ile Ile Lys Glu Ile Ile Glu Asn Gln 
        195                 200                 205             


Val Gln Lys Val Phe Lys Asn Arg Tyr Tyr Glu Glu His Leu Arg Glu 
    210                 215                 220                 


Lys Leu Leu Lys Asp Asp Lys Met Asp Val Ile Leu Thr Asn Phe Met 
225                 230                 235                 240 


Lys Ile Arg Glu Lys Ile Glu Ser Asn Pro Glu Ile Met Gly Phe Val 
                245                 250                 255     


Lys Phe Tyr Leu Asn Val Gly Gly Asp Lys Lys Lys Ser Glu Asn Lys 
            260                 265                 270         


Lys Met Phe Val Glu Lys Ile Leu Asn Ile Asn Val Asp Leu Thr Val 
        275                 280                 285             


Glu Asp Ile Val Asp Phe Ile Val Lys Glu Leu Lys Phe Trp Asn Ile 
    290                 295                 300                 


Thr Lys Arg Ile Glu Lys Val Lys Glu Phe Asn Asn Lys Phe Leu Glu 
305                 310                 315                 320 


Asn Lys Arg Asn Arg Thr Tyr Ile Lys Ser Tyr Val Leu Leu Asp Lys 
                325                 330                 335     


His Glu Lys Phe Lys Ile Glu Arg Glu Asn Lys Lys Asp Lys Ile Val 
            340                 345                 350         


Lys Phe Phe Val Glu Asn Ile Lys Asn Asn Ser Ile Lys Glu Lys Ile 
        355                 360                 365             


Glu Lys Ile Leu Ala Glu Phe Lys Ile Asp Glu Leu Thr Lys Lys Leu 
    370                 375                 380                 


Glu Lys Gly Asn Cys Asp Thr Glu Ile Phe Gly Ile Phe Lys Lys His 
385                 390                 395                 400 


Tyr Lys Val Asn Phe Asp Ser Lys Lys Phe Glu Asn Lys Ser Asp Glu 
                405                 410                 415     


Glu Lys Glu Leu Tyr Lys Ile Ile Tyr Arg Tyr Leu Lys Gly Arg Ile 
            420                 425                 430         


Glu Lys Ile Leu Ile Asn Glu Glu Lys Val Arg Leu Lys Lys Met Glu 
        435                 440                 445             


Lys Ile Glu Ile Glu Lys Ile Leu Asn Glu Ser Ile Leu Ser Glu Lys 
    450                 455                 460                 


Ile Leu Lys Arg Val Lys Gln Tyr Thr Leu Glu His Ile Met Tyr Leu 
465                 470                 475                 480 


Gly Lys Leu Val His Asn Lys Ile Asn Met Ala Thr Val Asn Thr Asn 
                485                 490                 495     


Asp Phe Phe Arg Leu His Ala Lys Glu Glu Leu Asp Leu Glu Leu Ile 
            500                 505                 510         


Thr Phe Leu Ala Ser Thr Asn Met Glu Leu Asn Lys Ile Phe Asn Gly 
        515                 520                 525             


Lys Glu Lys Val Thr Asp Phe Phe Gly Phe Asn Leu Asn Gly Gln Lys 
    530                 535                 540                 


Ile Thr Leu Lys Glu Lys Val Pro Ser Phe Lys Leu Asn Ile Leu Lys 
545                 550                 555                 560 


Lys Leu Asn Phe Ile Asn Asn Glu Asn Asn Ile Asp Glu Lys Leu Ser 
                565                 570                 575     


His Phe Tyr Ser Phe Gln Lys Lys Gly Tyr Leu Leu Arg Asn Lys Ile 
            580                 585                 590         


Leu His Asn Ser Tyr Gly Asn Ile Gln Glu Thr Ile Asn Leu Lys Gly 
        595                 600                 605             


Glu Tyr Glu Asn Val Glu Asn Leu Ile Lys Glu Leu Lys Val Ser Asn 
    610                 615                 620                 


Glu Glu Ile Ser Lys Ser Leu Asn Leu Asp Ile Ile Phe Glu Gly Lys 
625                 630                 635                 640 


Val Asp Ile Ile Asn Lys Ile Asn Ser Leu Glu Ile Gly Glu Tyr Lys 
                645                 650                 655     


Asp Lys Lys Tyr Leu Pro Ser Phe Ser Lys Ile Val Pro Glu Ile Met 
            660                 665                 670         


Arg Lys Phe Arg Glu Ile Asn Lys Asp Lys Ser Phe Asp Ile Glu Ser 
        675                 680                 685             


Glu Lys Ile Ile Leu Asn Ala Val Gln Tyr Val Asn Lys Ile Leu Tyr 
    690                 695                 700                 


Glu Lys Ile Thr Ser Asn Glu Glu Asn Glu Phe Ile Lys Thr Leu Pro 
705                 710                 715                 720 


Asp Lys Leu Val Lys Lys Asn Asn Asn Lys Glu Asn Asn Asn Ser Leu 
                725                 730                 735     


Ser Ile Glu Glu Tyr Tyr Lys Asn Ala Gln Ile Ser Ser Ser Lys Gly 
            740                 745                 750         


Asp Lys Lys Ala Ile Lys Lys Tyr Gln Asn Lys Val Thr Asn Ala Tyr 
        755                 760                 765             


Ile Glu Tyr Leu Glu Asn Thr Phe Ala Glu Val Ile Asp Phe Ser Asn 
    770                 775                 780                 


Phe Asn Leu Asn Phe Asp Glu Ile Lys Thr Lys Ile Glu Glu Arg Lys 
785                 790                 795                 800 


Tyr Ser Lys Ser Lys Ile Thr Val Asp Ser Ile Ser Thr Asn Ile Asn 
                805                 810                 815     


Ile Thr Asn Asp Ile Glu Tyr Ile Ile Ser Ile Phe Ala Leu Leu Asn 
            820                 825                 830         


Ser Asn Thr Tyr Ile Asn Lys Ile Arg Asn Arg Phe Phe Ala Thr Ser 
        835                 840                 845             


Val Trp Leu Asp Lys Gln Asn Ser Thr Lys Glu Tyr Asp Tyr Glu Asn 
    850                 855                 860                 


Ile Ile Asp Ile Leu Asp Lys Ile Leu Ser Ile Asn Leu Leu Arg Glu 
865                 870                 875                 880 


Asn Asn Ile Ala Asp Ile Leu Asp Leu Lys Asn Thr Ile Ile Glu Ala 
                885                 890                 895     


Lys Ile Val Glu Asn Asn Glu Glu Cys Ile Lys Asn Tyr Ile Phe Glu 
            900                 905                 910         


Asn Asn Glu Glu Glu Leu Lys Lys Arg Leu Phe Cys Glu Glu Leu Val 
        915                 920                 925             


Asn Lys Glu Asp Val Leu Lys Ile Phe Glu Asp Lys Asn Phe Lys Phe 
    930                 935                 940                 


Lys Asn Phe Ile Lys Lys Thr Gly Asn Glu Asn Phe Thr Ile Asn Phe 
945                 950                 955                 960 


Asp Ile Leu Phe Asn Leu Glu Cys Asn Ser Glu Leu Asn Val Lys Lys 
                965                 970                 975     


Val Met Gly Gln Asn Ser Gln Arg Leu Asn Leu Phe Ile Lys Asn Thr 
            980                 985                 990         


Ile Asp Glu Tyr Lys Ser Lys Ile  Lys Thr Ser Phe Ser  Ser Glu Phe 
        995                 1000                 1005             


Leu Glu  Lys Tyr Lys Lys Glu  Ile Asp Asn Leu Val  Glu Asp Thr 
    1010                 1015                 1020             


Glu Ser  Glu Asn Lys Asn Lys  Phe Glu Lys Ile Tyr  Tyr Pro Lys 
    1025                 1030                 1035             


Glu His  Lys Asn Glu Leu Tyr  Ile Tyr Lys Lys Asn  Leu Phe Leu 
    1040                 1045                 1050             


Asn Ile  Gly Asn Pro Asn Phe  Asp Lys Ile Tyr Glu  Leu Ile Ser 
    1055                 1060                 1065             


Lys Asp  Ile Lys Asn Ala Asn  Thr Glu Ile Leu Phe  Asp Asp Asp 
    1070                 1075                 1080             


Ile Arg  Lys Asn Lys Ile Ser  Glu Ile Asp Ala Ile  Leu Lys Asn 
    1085                 1090                 1095             


Leu Asn  Asp Lys Leu Asn Gly  Tyr Ser Asn Asp Tyr  Lys Ala Lys 
    1100                 1105                 1110             


Tyr Val  Asn Lys Leu Lys Glu  Asn Asp Asp Phe Phe  Ala Lys Asn 
    1115                 1120                 1125             


Met Lys  Asn Glu Asn Tyr Ser  Ser Phe Gly Glu Phe  Glu Lys Asp 
    1130                 1135                 1140             


Tyr Asn  Lys Val Ser Glu Tyr  Lys Lys Ile Arg Asp  Leu Val Glu 
    1145                 1150                 1155             


Phe Asn  Tyr Leu Asn Lys Ile  Glu Ser Tyr Leu Ile  Asp Ile Asn 
    1160                 1165                 1170             


Trp Lys  Leu Ala Ile Gln Met  Ala Arg Phe Glu Arg  Asp Met His 
    1175                 1180                 1185             


Tyr Ile  Val Asn Gly Leu Arg  Glu Leu Gly Ile Ile  Lys Leu Ser 
    1190                 1195                 1200             


Gly Tyr  Asn Thr Gly Ile Ser  Arg Ala Tyr Pro Lys  Arg Asn Gly 
    1205                 1210                 1215             


Ser Asp  Gly Phe Tyr Thr Thr  Thr Ala Tyr Tyr Lys  Phe Phe Asp 
    1220                 1225                 1230             


Glu Glu  Ser Tyr Lys Lys Phe  Glu Lys Ile Cys Tyr  Gly Phe Gly 
    1235                 1240                 1245             


Ile Asp  Leu Ser Glu Asn Ser  Glu Ile Asn Lys Pro  Glu Asn Glu 
    1250                 1255                 1260             


Ser Ile  Arg Asn Tyr Ile Ser  His Phe Tyr Ile Val  Arg Asn Pro 
    1265                 1270                 1275             


Phe Val  Asp Tyr Ser Ile Ala  Glu Gln Ile Asp Arg  Val Ser Asn 
    1280                 1285                 1290             


Leu Leu  Ser Tyr Ser Thr Arg  Tyr Asn Asn Ser Thr  Tyr Ala Ser 
    1295                 1300                 1305             


Val Phe  Glu Val Phe Lys Lys  Asp Val Asn Leu Asp  Tyr Asp Lys 
    1310                 1315                 1320             


Leu Lys  Thr Lys Phe Lys Leu  Phe Asp Asp Glu Lys  Asn Asp Asn 
    1325                 1330                 1335             


Ile Lys  Ile Leu Lys Ile Glu  Asn Leu Ile Glu Ser  Lys Lys Val 
    1340                 1345                 1350             


Ser Val  Leu Glu Leu Glu Ser  Tyr Asn Ser Asp Tyr  Ile Lys Asn 
    1355                 1360                 1365             


Leu Ile  Ile Glu Leu Leu Thr  Lys Ile Glu Asn Thr  Asn Asp Thr 
    1370                 1375                 1380             


Leu 
    


<210>  641
<211>  1197
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  641

Met Lys Val Thr Lys Ile Asp Gly Ile Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Arg Tyr Thr Gly Asn Phe Asn Ile Lys Asn Glu 
            20                  25                  30          


Met Lys Glu Arg Leu Glu Lys Leu Lys Glu Leu Lys Leu Ser Asn Tyr 
        35                  40                  45              


Val Lys Asn Pro Glu Asn Val Lys Asn Lys Asp Lys Asn Lys Glu Lys 
    50                  55                  60                  


Glu Thr Lys Ser Arg Arg Glu Asn Leu Lys Lys Tyr Phe Ser Glu Ile 
65                  70                  75                  80  


Ile Leu Arg Lys Lys Glu Glu Lys Tyr Leu Leu Lys Lys Thr Arg Lys 
                85                  90                  95      


Phe Lys Asn Ile Thr Glu Glu Ile Asn Tyr Asp Asp Ile Lys Lys Arg 
            100                 105                 110         


Glu Asn Gln Gln Lys Ile Phe Asp Val Leu Lys Glu Leu Leu Glu Gln 
        115                 120                 125             


Arg Ile Asn Glu Asn Asp Lys Glu Glu Ile Leu Asn Phe Asp Ser Val 
    130                 135                 140                 


Lys Leu Lys Glu Val Phe Gly Glu Asp Phe Ile Lys Lys Glu Ser Lys 
145                 150                 155                 160 


Ile Lys Ala Ile Glu Glu Ser Leu Glu Lys Asn Arg Ala Asp Tyr Arg 
                165                 170                 175     


Lys Asp Tyr Val Glu Leu Glu Asn Glu Lys Tyr Glu Asp Val Lys Gly 
            180                 185                 190         


Gln Asn Lys Arg Ser Leu Val Phe Glu Tyr Tyr Lys Asn Pro Glu Asn 
        195                 200                 205             


Arg Glu Lys Phe Lys Glu Asn Ile Lys Tyr Ala Phe Glu Asn Leu Tyr 
    210                 215                 220                 


Thr Glu Glu Asn Ile Lys Asn Leu Tyr Ser Glu Ile Glu Glu Ile Phe 
225                 230                 235                 240 


Gly Lys Val His Leu Lys Ser Lys Val Arg Asp Phe Tyr Gln Asn Arg 
                245                 250                 255     


Ile Ile Gly Glu Ser Glu Phe Ser Glu Lys Asp Glu Glu Gly Ile Ser 
            260                 265                 270         


Ile Leu Tyr Lys Gln Ile Ile Asn Ser Val Glu Lys Lys Glu Lys Phe 
        275                 280                 285             


Val Glu Phe Leu Gln Lys Val Lys Ile Lys Asp Leu Thr Arg Ser Gln 
    290                 295                 300                 


Ile Phe Tyr Lys Tyr Phe Leu Glu Asn Glu Glu Leu Asn Asp Glu Asn 
305                 310                 315                 320 


Ile Lys Tyr Val Phe Ser Tyr Phe Val Glu Ile Glu Val Asn Lys Leu 
                325                 330                 335     


Leu Lys Glu Asn Val Tyr Lys Thr Lys Lys Phe Asn Glu Gly Asn Lys 
            340                 345                 350         


Tyr Arg Val Lys Asn Ile Phe Asn Tyr Asp Lys Leu Lys Asn Leu Val 
        355                 360                 365             


Val Tyr Lys Leu Glu Asn Lys Leu Asn Asn Tyr Ile Arg Asn Cys Gly 
    370                 375                 380                 


Lys Tyr Asn Tyr His Met Glu Asn Gly Cys Val Ala Thr Ser Asp Thr 
385                 390                 395                 400 


Asn Met Lys Asn Arg Gln Thr Glu Ala Phe Leu Arg Ser Ile Leu Gly 
                405                 410                 415     


Val Ser Ser Phe Gly Tyr Phe Ser Leu Arg Asn Ile Leu Gly Val Asn 
            420                 425                 430         


Asp Asn Asp Phe Tyr Glu Ile Glu Glu Glu Leu Thr Glu Asp Glu Arg 
        435                 440                 445             


Lys Asn Glu Asn Phe Ile Leu Lys Lys Ala Lys Glu Asp Ile Thr Ser 
    450                 455                 460                 


Lys Asn Ile Phe Glu Lys Val Val Asp Lys Ser Phe Glu Lys Lys Gly 
465                 470                 475                 480 


Ile Tyr Gln Ile Lys Glu Asn Leu Lys Met Phe Tyr Gly Asn Ser Phe 
                485                 490                 495     


Asp Lys Val Asp Lys Asp Glu Leu Lys Lys Phe Phe Val Asn Met Leu 
            500                 505                 510         


Glu Ala Ile Thr Ser Val Arg His Arg Ile Val His Tyr Asn Ile Asn 
        515                 520                 525             


Thr Asn Ser Glu Asn Ile Phe Asp Phe Ser Asn Ile Glu Val Ser Lys 
    530                 535                 540                 


Leu Leu Lys Asn Ile Phe Glu Lys Glu Ile Asp Thr Arg Glu Leu Lys 
545                 550                 555                 560 


Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Gly Val Phe Asp Tyr Trp 
                565                 570                 575     


Glu Ser Trp Lys Ile Lys Lys Tyr Leu Glu Asn Ile Glu Phe Lys Phe 
            580                 585                 590         


Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys Leu Tyr Asn 
        595                 600                 605             


Arg Ile Asp Asn Leu Lys Gly Asn Asn Ala Leu Asn Leu Gly Tyr Ile 
    610                 615                 620                 


Asn Ile Pro Lys Arg Lys Glu Ala Lys Asp Ser Gln Ile Tyr Leu Leu 
625                 630                 635                 640 


Lys Asn Ile Tyr Tyr Gly Glu Phe Val Glu Lys Phe Val Asn Asp Asn 
                645                 650                 655     


Lys Asn Phe Glu Lys Ile Val Lys Glu Ile Ile Glu Ile Asn Arg Gly 
            660                 665                 670         


Ala Gly Thr Asn Lys Lys Thr Gly Phe Tyr Lys Leu Glu Lys Phe Glu 
        675                 680                 685             


Thr Leu Lys Ala Asn Thr Pro Ile Glu Tyr Leu Glu Lys Leu Gln Ser 
    690                 695                 700                 


Leu His Lys Ile Ser Tyr Asp Lys Glu Lys Ile Glu Glu Asp Lys Asp 
705                 710                 715                 720 


Ile Tyr Val Asp Phe Val Gln Lys Ile Phe Leu Lys Gly Phe Val Asn 
                725                 730                 735     


Tyr Leu Lys Lys Leu Asp Ser Leu Lys Ser Leu Asn Leu Leu Asn Leu 
            740                 745                 750         


Arg Lys Asp Glu Thr Ile Thr Asp Lys Lys Ser Phe His Asp Glu Lys 
        755                 760                 765             


Leu Lys Leu Trp Glu Asn Ser Gly Ser Asn Leu Ser Lys Met Pro Glu 
    770                 775                 780                 


Glu Ile Tyr Glu Tyr Val Lys Lys Ile Lys Ile Ser Asn Ile Asn Tyr 
785                 790                 795                 800 


Asn Asp Arg Met Ser Ile Phe Tyr Leu Leu Leu Lys Leu Ile Asp Tyr 
                805                 810                 815     


Arg Glu Leu Thr Asn Leu Arg Gly Asn Leu Glu Lys Tyr Glu Ser Met 
            820                 825                 830         


Asn Lys Asn Lys Ile Tyr Ser Glu Glu Leu Thr Ile Ile Asn Leu Val 
        835                 840                 845             


Asn Leu Asp Asn Asn Lys Val Arg Thr Asn Phe Ser Leu Glu Ala Glu 
    850                 855                 860                 


Asp Ile Gly Lys Phe Leu Lys Ser Ser Ile Thr Ile Lys Asn Ile Ala 
865                 870                 875                 880 


Gln Leu Asn Asn Phe Ser Lys Ile Phe Ala Asp Gly Glu Asn Val Ile 
                885                 890                 895     


Lys His Arg Ser Phe Tyr Asn Ile Lys Lys Tyr Gly Ile Leu Asp Leu 
            900                 905                 910         


Leu Glu Lys Met Ile Ala Arg Ala Asp Leu Lys Ile Ser Lys Glu Glu 
        915                 920                 925             


Ile Lys Lys Tyr Glu Asn Leu Gln Asn Glu Leu Lys Arg Asn Asp Phe 
    930                 935                 940                 


Tyr Lys Ile Gln Glu Gln Ile His Arg Asn Tyr Asn Gln Lys Pro Phe 
945                 950                 955                 960 


Ser Ile Lys Lys Ile Glu Asn Lys Lys Asp Phe Glu Lys Tyr Lys Lys 
                965                 970                 975     


Val Ile Glu Lys Ile Gln Asp Tyr Thr Gln Leu Lys Asn Lys Ile Glu 
            980                 985                 990         


Phe Asn Asp Leu Asn Leu Leu Gln  Ser Leu Ile Phe Arg  Ile Leu His 
        995                 1000                 1005             


Arg Leu  Ala Gly Tyr Thr Ser  Leu Trp Glu Arg Asp  Leu Gln Phe 
    1010                 1015                 1020             


Lys Leu  Lys Gly Glu Phe Pro  Glu Asp Lys Tyr Ile  Asp Glu Ile 
    1025                 1030                 1035             


Phe Asn  Ser Asp Gly Asn Asn  Asn Gln Lys Tyr Lys  His Gly Gly 
    1040                 1045                 1050             


Ile Thr  Asp Lys Tyr Ala Asn  Phe Leu Ile Glu Lys  Glu Glu Glu 
    1055                 1060                 1065             


Lys Ser  Gly Glu Ile Leu Lys  Lys Lys Gln Arg Lys  Lys Lys Ile 
    1070                 1075                 1080             


Lys Glu  Asp Leu Glu Ile Arg  Asn Tyr Ile Ala His  Phe Asn Tyr 
    1085                 1090                 1095             


Leu Pro  Asn Ala Glu Lys Ser  Ile Leu Glu Ile Leu  Glu Glu Leu 
    1100                 1105                 1110             


Arg Glu  Leu Leu Lys His Asp  Arg Lys Leu Lys Asn  Ala Val Met 
    1115                 1120                 1125             


Lys Ser  Ile Lys Asp Ile Phe  Lys Glu Tyr Gly Phe  Ile Val Glu 
    1130                 1135                 1140             


Phe Thr  Ile Ser His Thr Lys  Asn Gly Lys Lys Ile  Lys Val Cys 
    1145                 1150                 1155             


Ser Val  Lys Ser Glu Lys Ile  Lys His Leu Lys Asn  Asn Glu Leu 
    1160                 1165                 1170             


Ile Thr  Thr Arg Asn Ser Glu  Asp Leu Cys Asp Leu  Val Lys Ile 
    1175                 1180                 1185             


Met Leu  Glu Tyr Lys Lys Leu  Gln Lys 
    1190                 1195         


<210>  642
<211>  927
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  642

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Thr Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Val Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Lys Ile Pro Tyr Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr 
        915                 920                 925         


<210>  643
<211>  1182
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  643

Met Lys Gly Gly Ser Met Lys Ile Thr Lys Val Asp Gly Leu Ser His 
1               5                   10                  15      


Tyr Lys Lys Gln Asp Lys Gly Ile Leu Lys Lys Lys Trp Arg Asp Leu 
            20                  25                  30          


Asp Glu Arg Lys Gln Arg Glu Lys Ile Glu Glu Arg Tyr Asn Lys Gln 
        35                  40                  45              


Ile Glu Ser Lys Ile Tyr Lys Glu Phe Phe Arg Leu Lys Asn Lys Lys 
    50                  55                  60                  


Arg Ile Glu Lys Glu Glu Asp Gln Asn Ile Lys Ser Leu Tyr Phe Phe 
65                  70                  75                  80  


Ile Lys Glu Met Tyr Leu Asn Glu Glu Asn Glu Glu Trp Glu Leu Lys 
                85                  90                  95      


Asn Ile Asn Leu Glu Ile Leu Asp Asp Lys Glu Arg Val Ile Lys Gly 
            100                 105                 110         


Tyr Lys Phe Lys Glu Asp Val Tyr Phe Phe Lys Glu Gly Asp Lys Lys 
        115                 120                 125             


Tyr Tyr Leu Arg Thr Leu Leu Asn Asn Leu Ile Glu Lys Ile Gln Asn 
    130                 135                 140                 


Glu Asn Arg Asp Lys Val Arg Lys Asn Lys Glu Phe Ser Asp Leu Lys 
145                 150                 155                 160 


Glu Ile Phe Lys Lys Tyr Lys Asp Arg Lys Ile Lys Leu Leu Leu Glu 
                165                 170                 175     


Ser Ile Asn Asn Asn Lys Ile Asn Leu Glu Tyr Lys Lys Glu Asn Val 
            180                 185                 190         


Asn Glu Glu Ile Tyr Gly Ile Asn Pro Thr Asn Asp Arg Glu Met Thr 
        195                 200                 205             


Phe His Glu Leu Leu Lys Glu Ile Ile Glu Lys Lys Asp Glu Gln Lys 
    210                 215                 220                 


Ser Ile Leu Glu Glu Lys Leu Asp Asn Phe Asp Ile Thr Asn Phe Leu 
225                 230                 235                 240 


Glu Asn Ile Glu Lys Ile Phe Asn Glu Glu Thr Glu Ile Asn Ile Ile 
                245                 250                 255     


Lys Gly Lys Val Leu Asn Glu Leu Arg Glu Tyr Ile Arg Glu Lys Glu 
            260                 265                 270         


Glu Asn Asn Ser Asp Tyr Lys Leu Lys Gln Ile Tyr Asn Leu Glu Leu 
        275                 280                 285             


Lys Lys Tyr Ile Glu Asn Asn Phe Ser Tyr Lys Lys Gln Lys Ser Lys 
    290                 295                 300                 


Ser Lys Asn Gly Lys Asn Asp Tyr Leu Tyr Leu Asn Phe Leu Lys Lys 
305                 310                 315                 320 


Ile Met Phe Ile Glu Glu Val Asp Glu Lys Lys Gly Ile Asn Lys Glu 
                325                 330                 335     


Lys Phe Lys Asn Lys Ile Asn Ser Asn Phe Lys Asn Leu Phe Val Gln 
            340                 345                 350         


His Ile Leu Asp Tyr Gly Lys Leu Leu Tyr Tyr Lys Glu Asn Asp Glu 
        355                 360                 365             


Tyr Ile Lys Asn Thr Gly Gln Leu Glu Thr Lys Asp Leu Glu Tyr Ile 
    370                 375                 380                 


Lys Thr Lys Glu Thr Leu Ile Arg Lys Met Ala Val Leu Val Ser Phe 
385                 390                 395                 400 


Ala Ala Asn Ser Tyr Tyr Asn Leu Phe Gly Arg Thr Glu Asn Asn Ile 
                405                 410                 415     


Leu Thr Gln Glu Ile Ser Asp Asp Leu Leu Leu Gly Lys Ile Glu Asn 
            420                 425                 430         


Glu Ile Tyr Ile Lys Gly Glu Lys Asn Arg Arg Tyr Val Phe Lys Glu 
        435                 440                 445             


Lys Met Leu Asn Tyr Phe Phe Asn Pro Glu Ile Phe Gly Asp Asn Lys 
    450                 455                 460                 


Ile Val Glu Val Leu Ser Ala Ile Ser Ser Ser Ile Tyr Asn Ile Arg 
465                 470                 475                 480 


Asn Gly Val Asn His Phe Asp Lys Ile Asn Leu Gly Gln Tyr Asn Asn 
                485                 490                 495     


Leu Asp Leu Ser Glu Ile Lys Lys Tyr Phe Ile Glu Lys Arg Asp Lys 
            500                 505                 510         


Ile Lys Glu Lys Val Lys Glu Lys Phe Ser Ser Asn Asn Leu Gln Tyr 
        515                 520                 525             


Tyr Tyr Ala Lys Lys Glu Ile Glu Asn Tyr Phe Lys Ala Tyr Glu Phe 
    530                 535                 540                 


Glu Ile Leu Lys Glu Lys Ile Pro Phe Ala Pro Asn Phe Lys Arg Ile 
545                 550                 555                 560 


Ile Lys Lys Gly Glu Asp Leu Phe Asn Asn Lys Lys Asn Lys Lys Tyr 
                565                 570                 575     


Glu Tyr Phe Lys Asn Phe Asp Lys Asn Ile Ala Glu Glu Lys Lys Glu 
            580                 585                 590         


Phe Leu Lys Thr Arg Asn Phe Leu Leu Lys Glu Leu Tyr Tyr Asn Asn 
        595                 600                 605             


Phe Tyr Lys Glu Phe Leu Ser Lys Lys Glu Glu Phe Lys Lys Val Val 
    610                 615                 620                 


Ile Glu Val Lys Glu Glu Lys Lys Asn Arg Gly Asn Ile Asn Asn Lys 
625                 630                 635                 640 


Lys Ser Gly Val Ser Phe Gln Ser Ile Asp Asp Tyr Asp Thr Lys Ile 
                645                 650                 655     


Asn Ile Ser Asp Tyr Ile Ala Ser Ile His Lys Lys Glu Met Glu Arg 
            660                 665                 670         


Val Glu Lys Tyr Asn Glu Glu Lys Gln Lys Asp Thr Ala Lys Tyr Ile 
        675                 680                 685             


Arg Asp Phe Val Glu Glu Ile Phe Leu Thr Gly Phe Ile Asn Tyr Leu 
    690                 695                 700                 


Glu Lys Asp Lys Arg Leu His Phe Leu Lys Glu Glu Phe Ser Ile Leu 
705                 710                 715                 720 


Cys Asn Asn Asn Asn Asn Val Val Asp Phe Asn Ile Asn Ile Asn Glu 
                725                 730                 735     


Glu Lys Ile Lys Glu Phe Leu Lys Glu Asn Asp Ser Lys Thr Leu Asn 
            740                 745                 750         


Leu Tyr Leu Phe Phe Asn Met Ile Asp Ser Lys Arg Ile Ser Glu Phe 
        755                 760                 765             


Arg Asn Glu Leu Ile Lys Tyr Lys Gln Phe Thr Lys Arg Arg Leu Asp 
    770                 775                 780                 


Glu Lys Lys Glu Phe Leu Gly Ile Glu Ile Glu Leu Tyr Glu Thr Leu 
785                 790                 795                 800 


Ile Glu Phe Val Ile Leu Thr Arg Glu Lys Leu Asp Thr Lys Lys Ser 
                805                 810                 815     


Glu Glu Ile Asp Ala Trp Leu Val Asp Lys Leu Tyr Val Lys Asp Asn 
            820                 825                 830         


Asn Glu Tyr Lys Glu Tyr Glu Glu Ile Leu Lys Leu Phe Val Asp Glu 
        835                 840                 845             


Lys Ile Leu Ser Ser Lys Glu Ala Pro Tyr Tyr Ala Thr Asp Asn Lys 
    850                 855                 860                 


Thr Pro Ile Leu Leu Ser Asn Phe Glu Lys Thr Arg Lys Tyr Gly Thr 
865                 870                 875                 880 


Gln Ser Phe Leu Ser Glu Ile Gln Ser Asn Tyr Lys Tyr Ser Lys Val 
                885                 890                 895     


Glu Lys Glu Asn Ile Glu Asp Tyr Asn Lys Lys Glu Glu Ile Glu Gln 
            900                 905                 910         


Lys Lys Lys Ser Asn Ile Glu Lys Leu Gln Asp Leu Lys Val Glu Leu 
        915                 920                 925             


His Lys Lys Trp Glu Gln Asn Lys Ile Thr Glu Arg Glu Ile Lys Lys 
    930                 935                 940                 


Tyr Asn Asp Thr Ile Lys Glu Ile Arg Glu Tyr Asn Tyr Leu Lys Asn 
945                 950                 955                 960 


Lys Glu Glu Leu Gln Asn Val Tyr Leu Leu His Glu Met Leu Ser Asp 
                965                 970                 975     


Leu Leu Ala Arg Asn Val Ala Phe Phe Asn Lys Trp Glu Arg Asp Phe 
            980                 985                 990         


Lys Phe Ile Val Ile Ala Ile Lys  Gln Phe Leu Arg Glu  Asn Asp Lys 
        995                 1000                 1005             


Glu Lys  Val Asn Glu Phe Leu  Asn Pro His Lys Ser  Asp Gly Ser 
    1010                 1015                 1020             


Arg Asp  Asn Phe Ser Val Thr  Asn Tyr Arg Ser Lys  Met Lys Ser 
    1025                 1030                 1035             


Ile Ile  Asn Asn Ile His Glu  Asn Phe Met Ser Leu  Leu Phe Leu 
    1040                 1045                 1050             


Asn Asn  Asn Leu Ala Thr Gly  Gly Ile Gln Met Gly  Arg Asn Asn 
    1055                 1060                 1065             


Asn Phe  Thr Trp Gly Asn Leu  Arg Asn Tyr Ile Ala  His Phe Glu 
    1070                 1075                 1080             


Tyr Leu  His Lys Glu Lys Asp  Thr Ile Ser Phe Leu  Asn Gln Ala 
    1085                 1090                 1095             


Asn Leu  Leu Ile Lys Leu Phe  Ser Tyr Asp Lys Lys  Val Gln Asn 
    1100                 1105                 1110             


His Ile  Ile Lys Ser Met Lys  Thr Leu Leu Glu Lys  Tyr Asn Ile 
    1115                 1120                 1125             


Glu Ile  Gly Phe Glu Ile Ser  Asn Asp Ser Glu Glu  Ile Phe Glu 
    1130                 1135                 1140             


Tyr Lys  Ile Lys Tyr Ile Asn  Ser Lys Lys Gly Lys  Met Leu Gly 
    1145                 1150                 1155             


Lys Asn  Asn Glu Phe Glu Ile  Leu Glu Asn Glu Phe  Val Arg Asn 
    1160                 1165                 1170             


Val Lys  Ala Leu Leu Glu Tyr  Ser Lys 
    1175                 1180         


<210>  644
<211>  1167
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  644

Met Lys Val Thr Lys Val Gly Gly Ile Ser His Lys Lys Tyr Thr Ser 
1               5                   10                  15      


Glu Gly Arg Leu Val Lys Ser Glu Ser Glu Glu Asn Arg Thr Asp Glu 
            20                  25                  30          


Arg Leu Ser Ala Leu Leu Asn Met Arg Leu Asp Met Tyr Ile Lys Asn 
        35                  40                  45              


Pro Ser Asn Thr Glu Thr Lys Glu Asn Lys Lys Arg Ile Gly Lys Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Met Val Tyr Leu Lys Asp Asn Thr Leu 
65                  70                  75                  80  


Ser Leu Lys Asn Gly Lys Lys Glu Asn Ile Asp Arg Glu Tyr Ser Glu 
                85                  90                  95      


Thr Asp Ile Ser Glu Tyr Asp Val Arg Asp Ser Lys Asn Phe Ala Val 
            100                 105                 110         


Leu Lys Lys Ile Tyr Leu Asn Glu Asn Val Asn Ser Glu Glu Leu Glu 
        115                 120                 125             


Val Phe Arg Lys Asp Ile Lys Lys Lys Leu Asn Lys Ile Asn Ser Leu 
    130                 135                 140                 


Lys Tyr Ser Phe Glu Lys Asn Lys Ala Asn Tyr Gln Lys Ile Asn Glu 
145                 150                 155                 160 


Asn Asn Ile Glu Lys Val Glu Gly Lys Ser Lys Arg Asn Ile Ile Tyr 
                165                 170                 175     


Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asp Ala Tyr Val Ser Asn Val 
            180                 185                 190         


Lys Glu Ala Phe Asp Lys Leu Tyr Lys Glu Glu Asp Ile Ala Lys Leu 
        195                 200                 205             


Val Leu Lys Ile Glu Asn Leu Thr Lys Leu Glu Lys Ser Lys Ile Arg 
    210                 215                 220                 


Glu Phe Tyr His Glu Ile Ile Gly Arg Lys Asn Asp Lys Glu Asn Phe 
225                 230                 235                 240 


Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Met Lys Glu 
                245                 250                 255     


Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser Gln Val 
            260                 265                 270         


Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Glu Asn Val 
        275                 280                 285             


Lys Tyr Val Phe Cys His Phe Val Glu Ile Glu Met Ser Lys Leu Leu 
    290                 295                 300                 


Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp Lys Val 
305                 310                 315                 320 


Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu Asn Lys 
                325                 330                 335     


Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys Tyr Asn 
            340                 345                 350         


Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile Ala Arg 
        355                 360                 365             


Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val Ser Ser 
    370                 375                 380                 


Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn Lys Asp 
385                 390                 395                 400 


Asp Ile Thr Gly Lys Met Arg Gly Lys Thr Arg Ile Glu Ser Lys Thr 
                405                 410                 415     


Gly Glu Glu Lys Tyr Ile Pro Gly Glu Val Asp Gln Ile Tyr Tyr Glu 
            420                 425                 430         


Asn Lys Gln Asn Glu Val Lys Asn Lys Leu Lys Met Phe Tyr Gly Tyr 
        435                 440                 445             


Asp Phe Asp Met Asp Asn Lys Lys Glu Ile Glu Asp Phe Phe Ala Asn 
    450                 455                 460                 


Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe Asn 
465                 470                 475                 480 


Leu Asp Leu Asp Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Val Pro 
                485                 490                 495     


Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys Lys 
            500                 505                 510         


Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe Arg 
        515                 520                 525             


Tyr Leu Glu Lys Asp Arg Ile Leu Asp Tyr Leu Arg Ser Thr Arg Phe 
    530                 535                 540                 


Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys Leu 
545                 550                 555                 560 


Tyr Asp Arg Ile Asp Asp Leu Lys Ile Ser Leu Asn Ile Tyr Trp Lys 
                565                 570                 575     


Thr Pro Lys Thr Asn Asp Asp Ile Lys Thr Lys Glu Ile Thr Asp Ala 
            580                 585                 590         


Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Lys Phe Leu Asp Tyr 
        595                 600                 605             


Phe Met Ser Arg Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Val Ile 
    610                 615                 620                 


Lys Leu Asn Lys Asn Asn Lys Lys Asn Val Lys Thr Gly Phe Tyr Lys 
625                 630                 635                 640 


Leu Gln Lys Phe Glu Asn Leu Glu Ala Arg Ser Pro Lys Glu Tyr Leu 
                645                 650                 655     


Ala Lys Val Gln Ser Leu Tyr Ile Ile Asn Val Ala Asn Gln Asp Glu 
            660                 665                 670         


Glu Glu Lys Asn Thr Tyr Ile Asp Phe Ile Gln Lys Val Phe Leu Lys 
        675                 680                 685             


Gly Phe Ile Thr Tyr Leu Ala Asn Asn Arg Arg Leu Ser Leu Met Tyr 
    690                 695                 700                 


Ile Gly Ser Asp Glu Glu Val Asn Asn Ser Leu Ala Glu Lys Lys Gln 
705                 710                 715                 720 


Glu Phe Asp Lys Phe Trp Arg Lys Tyr Glu Glu Asn Asn Asp Ile Glu 
                725                 730                 735     


Ile Pro Asp Glu Ile Asn Glu Phe Leu Lys Glu Ile Lys Leu Gly Lys 
            740                 745                 750         


Ile Leu Lys Asn Ser Ala Lys Leu Asn Ile Phe Tyr Leu Ile Leu Lys 
        755                 760                 765             


Leu Leu Asn Asn Lys Glu Phe Thr Asn Leu Lys Gly Asn Leu Glu Lys 
    770                 775                 780                 


Tyr His Ser Ala Asn Glu Val Asn Ile Phe Ser Asp Glu Leu Glu Leu 
785                 790                 795                 800 


Ile Asn Phe Leu Asn Leu Asp Asn Asn Lys Val Lys Glu Asp Phe Glu 
                805                 810                 815     


Phe Glu Ala Asp Glu Ile Gly Lys Phe Leu Asn Phe Asn Gly Asn Lys 
            820                 825                 830         


Ile Lys Asn Arg Glu Glu Leu Lys Lys Phe Asp Thr Thr Lys Met Tyr 
        835                 840                 845             


Phe Tyr Lys Glu Asn Ile Ile Lys Tyr Arg Ala Tyr Tyr Asn Ile Lys 
    850                 855                 860                 


Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala Gly 
865                 870                 875                 880 


Tyr Lys Ile Ser Ile Glu Glu Leu Lys Lys Tyr Ser Asn Lys Lys Asn 
                885                 890                 895     


Glu Ile Glu Lys Asn His Lys Met Gln Glu Asn Leu His Arg Lys Tyr 
            900                 905                 910         


Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Glu Ser 
        915                 920                 925             


Tyr Lys Gln Ala Ile Lys Asn Ile Glu Glu Tyr Thr His Leu Lys Asn 
    930                 935                 940                 


Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu Arg 
945                 950                 955                 960 


Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp Leu 
                965                 970                 975     


Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu Glu 
            980                 985                 990         


Ile Phe Asn Phe Glu Asn Lys Lys  Asn Met Lys Tyr Lys  Ser Gly Gln 
        995                 1000                 1005             


Ile Val  Glu Lys Tyr Ile Lys  Phe Tyr Lys Glu Leu  His Gln Asn 
    1010                 1015                 1020             


Asp Glu  Val Lys Ile Asn Lys  Tyr Ser Ser Ala Asn  Ile Lys Val 
    1025                 1030                 1035             


Leu Lys  Gln Glu Lys Lys Asp  Leu Tyr Ile Arg Asn  Tyr Ile Ala 
    1040                 1045                 1050             


His Phe  Asn Tyr Ile Pro His  Ala Glu Ile Ser Leu  Leu Glu Val 
    1055                 1060                 1065             


Leu Glu  Asn Leu Arg Lys Leu  Leu Ser Tyr Asp Arg  Lys Leu Lys 
    1070                 1075                 1080             


Asn Ala  Val Met Lys Ser Val  Val Asp Ile Leu Lys  Glu Tyr Gly 
    1085                 1090                 1095             


Phe Val  Val Lys Phe Lys Ile  Gly Ala Asp Lys Lys  Ile Glu Ile 
    1100                 1105                 1110             


Gln Ser  Leu Lys Ser Glu Glu  Ile Val His Leu Lys  Lys Leu Lys 
    1115                 1120                 1125             


Leu Lys  Asp Asn Asp Lys Lys  Lys Glu Pro Ile Lys  Thr Tyr Arg 
    1130                 1135                 1140             


Asn Ser  Lys Glu Leu Cys Lys  Leu Val Lys Val Met  Phe Glu Tyr 
    1145                 1150                 1155             


Lys Met  Glu Glu Lys Ser Ser  Glu Lys 
    1160                 1165         


<210>  645
<211>  1286
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  645

Met Lys Ile Ser Lys Val Asp His Val Lys Ser Gly Ile Asp Gln Lys 
1               5                   10                  15      


Leu Ser Ser Gln Arg Gly Met Leu Tyr Lys Gln Pro Gln Lys Lys Tyr 
            20                  25                  30          


Glu Gly Lys Gln Leu Glu Glu His Val Arg Asn Leu Ser Arg Lys Ala 
        35                  40                  45              


Lys Ala Leu Tyr Gln Val Phe Pro Val Ser Gly Asn Ser Lys Met Glu 
    50                  55                  60                  


Lys Glu Leu Gln Ile Ile Asn Ser Phe Ile Lys Asn Ile Leu Phe Arg 
65                  70                  75                  80  


Leu Asp Ser Gly Lys Thr Ser Glu Glu Ile Val Gly Tyr Ile Asn Thr 
                85                  90                  95      


Tyr Ser Val Ala Ser Gln Ile Ser Gly Asp His Ile Gln Glu Leu Val 
            100                 105                 110         


Asp Gln His Leu Lys Glu Ser Leu Arg Lys Tyr Thr Cys Val Gly Asp 
        115                 120                 125             


Lys Arg Ile Tyr Val Pro Asp Ile Ile Val Ala Leu Leu Lys Ser Lys 
    130                 135                 140                 


Phe Asn Ser Glu Thr Leu Gln Tyr Asp Asn Ser Glu Leu Lys Ile Leu 
145                 150                 155                 160 


Ile Asp Phe Ile Arg Glu Asp Tyr Leu Lys Glu Lys Gln Ile Lys Gln 
                165                 170                 175     


Ile Val His Ser Ile Glu Asn Asn Ser Thr Pro Leu Arg Ile Ala Glu 
            180                 185                 190         


Ile Asn Gly Gln Lys Arg Leu Ile Pro Ala Asn Ala Asp Asn Pro Lys 
        195                 200                 205             


Lys Ser Tyr Ile Phe Glu Phe Leu Lys Glu Tyr Ala Gln Ser Asp Pro 
    210                 215                 220                 


Lys Gly Gln Glu Ser Leu Leu Gln His Met Arg Tyr Leu Ile Leu Leu 
225                 230                 235                 240 


Tyr Leu Tyr Gly Pro Asp Lys Ile Thr Asp Asp Tyr Cys Glu Glu Ile 
                245                 250                 255     


Gly Ala Trp Asn Phe Gly Ser Ile Val Met Asp Asn Glu Gln Leu Phe 
            260                 265                 270         


Ser Glu Glu Ala Ser Met Leu Ile Gln Asp Arg Ile Tyr Val Asn Gln 
        275                 280                 285             


Gln Ile Gln Glu Gly Arg Gln Ser Lys Asp Thr Ala Lys Val Lys Lys 
    290                 295                 300                 


Asn Lys Ser Lys Tyr Arg Met Leu Gly Asp Lys Ile Glu His Ser Ile 
305                 310                 315                 320 


Asn Glu Ser Ile Val Lys His Tyr Gln Glu Ala Cys Lys Ala Val Glu 
                325                 330                 335     


Glu Lys Asp Ile Pro Trp Ile Lys Tyr Ile Ser Asp His Val Met Ser 
            340                 345                 350         


Val Tyr Ser Ser Lys Asn Arg Val Asp Leu Asp Lys Leu Ser Leu Pro 
        355                 360                 365             


Tyr Leu Ala Lys Asn Thr Trp Asn Thr Trp Ile Ser Phe Ile Ala Met 
    370                 375                 380                 


Lys Tyr Val Asp Met Gly Lys Gly Val Tyr His Phe Ala Met Ser Asp 
385                 390                 395                 400 


Val Asp Lys Val Gly Lys Gln Asp Asn Leu Ile Ile Gly Gln Ile Asp 
                405                 410                 415     


Pro Lys Phe Ser Asp Gly Ile Ser Ser Phe Asp Tyr Glu Arg Ile Lys 
            420                 425                 430         


Ala Glu Asp Asp Leu His Arg Ser Met Ser Gly Tyr Ile Ala Phe Ala 
        435                 440                 445             


Val Asn Asn Phe Ala Arg Ala Ile Cys Ser Asp Glu Phe Arg Lys Lys 
    450                 455                 460                 


Asp Lys Lys Glu Asp Val Leu Thr Val Gly Leu Asp Lys Met Pro Leu 
465                 470                 475                 480 


Asp Asp Asn Val Lys Arg Lys Leu Leu Gln Tyr Phe Gly Gly Ala Ser 
                485                 490                 495     


Asn Trp Asp Asp Ser Ile Met Asp Ile Ile Asp Asp Lys Asp Leu Ala 
            500                 505                 510         


Ala Cys Ile Lys Glu Asn Leu Tyr Val Ala Arg Asn Val Asn Phe His 
        515                 520                 525             


Phe Ala Gly Ser Glu Lys Val Gln Lys Lys Gln Asp Asp Ile Leu Glu 
    530                 535                 540                 


Glu Ile Val Arg Lys Glu Thr Gly Asp Ile Gly Lys His Tyr Arg Lys 
545                 550                 555                 560 


Val Phe Tyr Ser Asn Asn Val Ala Val Phe Tyr Arg Asp Glu Asp Ile 
                565                 570                 575     


Ile Lys Leu Met Asn His Leu Tyr Gln Lys Glu Lys Pro Tyr Gln Ala 
            580                 585                 590         


Gln Ile Pro Ser Tyr Asn Lys Val Ile Ser Lys Thr Tyr Leu Pro Asp 
        595                 600                 605             


Leu Ile Phe Met Leu Leu Lys Gly Lys Asn Arg Thr Lys Ile Ser Asp 
    610                 615                 620                 


Pro Ser Ile Met Asn Met Phe Arg Gly Thr Phe Tyr Phe Leu Leu Lys 
625                 630                 635                 640 


Glu Ile Tyr Tyr Asn Asp Phe Leu Gln Ala Ser Asn Leu Lys Glu Met 
                645                 650                 655     


Phe Cys Glu Gly Leu Lys Asn Asn Val Lys Asp Lys Lys Ser Glu Lys 
            660                 665                 670         


Pro Tyr Gln Asn Phe Met Gln Arg Phe Glu Glu Leu Glu Asn Met Gly 
        675                 680                 685             


Met Asp Phe Gly Glu Ile Cys Gln Gln Ile Met Thr Asp Tyr Glu Gln 
    690                 695                 700                 


Gln Asn Lys Gln Lys Lys Lys Thr Ala Thr Ala Val Met Ser Glu Lys 
705                 710                 715                 720 


Asp Lys Lys Ile Arg Ile Leu Asp Asn Asp Ile Gln Lys Tyr Lys His 
                725                 730                 735     


Phe Arg Thr Leu Leu Tyr Val Gly Leu Arg Glu Ala Phe Ile Ile Tyr 
            740                 745                 750         


Leu Lys Asp Glu Lys Asn Lys Glu Trp Tyr Glu Phe Leu Arg Glu Pro 
        755                 760                 765             


Val Lys Arg Glu Gln Pro Glu Glu Glu Glu Phe Val Asn Lys Trp Lys 
    770                 775                 780                 


Leu Asn Gln Tyr Ser Asp Cys Ser Glu Leu Ile Leu Lys Asp Pro Leu 
785                 790                 795                 800 


Ala Ala Ala Trp Tyr Val Ala Ala His Phe Ile Asn Gln Ala Gln Leu 
                805                 810                 815     


Asn His Leu Ile Gly Asp Ile Lys Asn Tyr Ile Gln Phe Ile Ser Asp 
            820                 825                 830         


Ile Asp Arg Arg Ala Lys Ser Thr Gly Asn Pro Val Ser Glu Ser Thr 
        835                 840                 845             


Glu Ile Gln Ile Glu Arg Tyr Arg Gln Ile Leu Arg Val Leu Glu Phe 
    850                 855                 860                 


Ala Lys Phe Phe Cys Gly Gln Ile Thr Asn Val Leu Thr Asp Tyr Tyr 
865                 870                 875                 880 


Glu Asp Glu Asn Asp Phe Ser Thr His Val Gly His Tyr Val Lys Phe 
                885                 890                 895     


Glu Lys Lys Asn Met Glu Pro Ala His Ala Leu Gln Ala Phe Ser Asn 
            900                 905                 910         


Ser Leu Tyr Ala Cys Gly Lys Glu Lys Lys Lys Ala Gly Phe Tyr Tyr 
        915                 920                 925             


Asp Gly Met Asn Pro Ile Val Asn Arg Asn Ile Thr Leu Ala Ser Met 
    930                 935                 940                 


Tyr Gly Asn Lys Lys Leu Leu Glu Asn Ala Met Asn Pro Val Thr Glu 
945                 950                 955                 960 


Gln Asp Ile Arg Lys Tyr Tyr Ser Leu Met Ala Glu Leu Asp Ser Ile 
                965                 970                 975     


Leu Lys Asn Gly Ala Val Cys Lys Ser Glu Asp Glu Gln Lys Asn Leu 
            980                 985                 990         


Arg His Phe Gln Asn Leu Lys Asn  Arg Ile Glu Leu Val  Asp Val Leu 
        995                 1000                 1005             


Thr Leu  Ser Glu Leu Val Asn  Asp Leu Val Ala Gln  Leu Ile Gly 
    1010                 1015                 1020             


Trp Ala  Tyr Ile Arg Glu Arg  Asp Met Met Tyr Leu  Gln Leu Gly 
    1025                 1030                 1035             


Leu His  Tyr Ile Lys Leu Tyr  Phe Thr Asp Ser Val  Ser Asp Asp 
    1040                 1045                 1050             


Ser Tyr  Leu Arg Thr Leu Asp  Leu Glu Glu Gly Ser  Ile Ala Asp 
    1055                 1060                 1065             


Gly Ala  Val Leu Tyr Gln Ile  Ala Ser Leu Tyr Ser  Phe Asn Leu 
    1070                 1075                 1080             


Pro Met  Tyr Val Lys Pro Asn  Glu Ser Ser Val Tyr  Cys Lys Lys 
    1085                 1090                 1095             


His Ala  Asn Ser Val Ala Ala  Lys Phe Arg Ile Phe  Glu Lys Glu 
    1100                 1105                 1110             


Tyr Cys  Asn Thr Asn Gly Lys  Thr Asp Gly Thr Val  Ile Glu Asn 
    1115                 1120                 1125             


Gly Leu  Cys Leu Phe Glu Asn  Ile Lys Leu His Gly  Asp Leu Ala 
    1130                 1135                 1140             


Glu Phe  Arg Asp Tyr Leu Ala  His Phe Lys Tyr Phe  Ala Lys Leu 
    1145                 1150                 1155             


Asp Lys  Ser Ile Leu Glu Leu  Tyr Ser Lys Val Tyr  Asp Ser Phe 
    1160                 1165                 1170             


Phe Ser  Tyr Asn Ile Lys Leu  Lys Lys Ser Val Ser  Tyr Val Phe 
    1175                 1180                 1185             


Thr Asn  Ile Leu Leu Ser Tyr  Phe Ile Asn Ala Lys  Leu Ser Phe 
    1190                 1195                 1200             


Ser Leu  Cys Gly Ile Ser Asp  Tyr Lys Pro Ser Arg  Asn Lys Ile 
    1205                 1210                 1215             


Val Gln  Arg Arg Ser Ala Asn  Ile Ser Ile Glu Ser  Val Gln Thr 
    1220                 1225                 1230             


Asp Tyr  Phe Thr Tyr Lys Leu  Arg Ser Ile Val Lys  Asn Lys Asn 
    1235                 1240                 1245             


Gly Val  Glu Ser Ile Glu Asn  Asp Glu Arg Lys Cys  Glu Val Val 
    1250                 1255                 1260             


Asn Ile  Ala Ala Arg Asp Lys  Glu Phe Val Asn Glu  Val Cys Lys 
    1265                 1270                 1275             


Val Ile  Asn Tyr Asn Ser Asp  Arg 
    1280                 1285     


<210>  646
<211>  1364
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  646

Met Pro Arg Gly Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg 
1               5                   10                  15      


Pro Gly Ile Ser Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg 
            20                  25                  30          


Gln Ser Leu Leu Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu 
        35                  40                  45              


Glu Ser Lys Asp Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala 
    50                  55                  60                  


Gln Lys Leu Tyr Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp 
65                  70                  75                  80  


Glu Asn Arg Gln Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala 
                85                  90                  95      


Val Ile Asn Asn Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys 
            100                 105                 110         


Glu Gln Arg Val Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys 
        115                 120                 125             


Lys Ser Ile Lys Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu 
    130                 135                 140                 


Ile Val Lys Phe Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys 
145                 150                 155                 160 


Gly Thr Gly Ser Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu 
                165                 170                 175     


Val Leu Arg Lys Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu 
            180                 185                 190         


Asn Gly Tyr Arg Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser 
        195                 200                 205             


Ala Ile Cys Leu Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu 
    210                 215                 220                 


Lys Ala Phe Phe Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr 
225                 230                 235                 240 


Val Glu Gln Ile Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys 
                245                 250                 255     


Val Val Glu Lys Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp 
            260                 265                 270         


His Arg Lys Lys Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala 
        275                 280                 285             


Ala Asp Glu Lys Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu 
    290                 295                 300                 


Ile Gly Leu Tyr Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn 
305                 310                 315                 320 


Arg Phe Ser Asp Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile 
                325                 330                 335     


Glu Glu Ile Leu Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys 
            340                 345                 350         


Lys Lys Glu Asn Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys 
        355                 360                 365             


Tyr Arg Ala Ala Val Asn Tyr Leu Ala Asp Glu Val Arg Lys Thr Val 
    370                 375                 380                 


Leu Gly Glu Ile Arg Glu Lys Lys Val Cys Ser Cys Ala Asp Leu Tyr 
385                 390                 395                 400 


Trp Ile Glu Tyr Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser 
                405                 410                 415     


Arg Asn Lys Lys Arg Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His 
            420                 425                 430         


Ile Trp Lys Glu Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met 
        435                 440                 445             


Gly Lys Gly Val Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu 
    450                 455                 460                 


Glu Gly Glu Pro Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn 
465                 470                 475                 480 


Gly Val Ser Gly Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu 
                485                 490                 495     


Glu Arg Glu Met Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala 
            500                 505                 510         


Arg Ala Val Thr Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp 
        515                 520                 525             


Val Leu Leu Met Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys 
    530                 535                 540                 


Glu Glu Arg Gln Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr 
545                 550                 555                 560 


Leu Tyr Ala Asp Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln 
                565                 570                 575     


Ser Arg Phe Arg Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly 
            580                 585                 590         


Glu Asp Leu Tyr Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn 
        595                 600                 605             


Ile Thr Phe His Tyr Thr Thr Lys Ala Glu Lys Asp Gln Thr Gln Lys 
    610                 615                 620                 


His Asp Leu Ala Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr 
625                 630                 635                 640 


Glu Leu Phe Arg Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr 
                645                 650                 655     


Asp Ala Glu Val Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg 
            660                 665                 670         


Lys Tyr Arg Ala Ala Gln Val Pro Ala Leu Lys Asn Ile Ile Ser Arg 
        675                 680                 685             


Pro Glu Leu Pro Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu 
    690                 695                 700                 


Arg Arg Leu Met Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp 
705                 710                 715                 720 


Ser Ala Leu Phe Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu 
                725                 730                 735     


Gln Glu Gln Lys Arg Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg 
            740                 745                 750         


Ala Ile Lys Lys Leu Ser Gly Gln Glu Lys Gly Asp Lys Glu Gln Lys 
        755                 760                 765             


Ala Trp Glu Ser Phe Glu Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg 
    770                 775                 780                 


Ser Phe Gly Ala Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln 
785                 790                 795                 800 


Asn Ser Asp Ile Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala 
                805                 810                 815     


Asn Asn Lys Lys Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn 
            820                 825                 830         


Cys Ile Arg Glu Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu 
        835                 840                 845             


Leu Arg Thr Pro Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe 
    850                 855                 860                 


Cys Arg Val Asp Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys 
865                 870                 875                 880 


Glu Thr Phe Asn Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala 
                885                 890                 895     


His Phe Ile Asn Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg 
            900                 905                 910         


Asn Tyr Leu Gln Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu 
        915                 920                 925             


Gly Asp Cys Val Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg 
    930                 935                 940                 


Asn Thr Leu Glu Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr 
945                 950                 955                 960 


Thr Asn Val Met Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu 
                965                 970                 975     


Tyr Leu Ser Gly Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp 
            980                 985                 990         


Ile Glu Lys Ala Leu Tyr Ser Phe  Cys Lys Gln Lys Phe  Lys Val Asp 
        995                 1000                 1005             


Gly Lys  Glu Tyr Met Ala Gly  Ile Tyr Tyr Asp Gly  Glu Asn Leu 
    1010                 1015                 1020             


Ile Pro  Asn Arg Asn Ile Ile  Arg Ala Asn Met Tyr  Gly Asn Thr 
    1025                 1030                 1035             


Ser Cys  Leu Lys Pro Cys Met  Asp Arg Ile Thr Leu  Lys Glu Ile 
    1040                 1045                 1050             


Arg Thr  Met Tyr Ala Asp Gln  Asn Lys Leu Asp Leu  Val Leu Lys 
    1055                 1060                 1065             


Glu Gly  Val Cys His Thr Glu  Glu Glu Gln Lys Ala  Tyr Arg Glu 
    1070                 1075                 1080             


Tyr Gln  Asn Glu Lys Asn Arg  Ile Glu Leu Phe Asp  Val Cys Thr 
    1085                 1090                 1095             


Tyr Thr  Gln Ile Leu Asn Asp  Met Gln Ala Arg Leu  Ile Gly Trp 
    1100                 1105                 1110             


Ser Tyr  Met Arg Glu Arg Asp  Leu Met Tyr Tyr Gln  Leu Gly Tyr 
    1115                 1120                 1125             


Tyr Tyr  Thr Lys Leu Phe Trp  Thr Asp Ser Ile Ser  Glu Glu Asp 
    1130                 1135                 1140             


Ala Arg  Arg Arg Leu Val Gly  Asn Leu Val Asn Val  Glu Asp Gly 
    1145                 1150                 1155             


Ala Ile  Leu Tyr Gln Ile Leu  Ala Phe Asn Ser Tyr  Asn Leu Pro 
    1160                 1165                 1170             


Ile Ile  Ala Asn Lys Asn Asn  Thr Val Thr Leu Leu  Lys Asp Glu 
    1175                 1180                 1185             


Gly Ser  Ile Gly Gly Lys Ala  Ile Thr Ala Phe Phe  Lys Asn Tyr 
    1190                 1195                 1200             


Glu Asn  Ala Glu Met Ile Tyr  Glu Glu Ala Leu Asp  Leu Phe Glu 
    1205                 1210                 1215             


Asn Met  Asp Glu His Ala Ala  Ile Ile Asn Thr Arg  Asn Tyr Ile 
    1220                 1225                 1230             


Glu His  Phe Lys Tyr Phe Ile  Lys Ser Asp Arg Ser  Met Met Asp 
    1235                 1240                 1245             


Leu Tyr  Ser Glu Ile Tyr Asp  Arg Phe Phe Arg His  Asp His Asn 
    1250                 1255                 1260             


Arg Lys  Lys Asn Val Pro Asp  Ser Leu Lys Asn Val  Leu Ala Asp 
    1265                 1270                 1275             


Asn Phe  Met Ile Val Asp Ile  Asp Met Glu Leu Gly  Ser Lys Lys 
    1280                 1285                 1290             


Val Gly  Glu Lys Lys Lys Gly  Phe Arg Glu His Lys  Ala Ala Arg 
    1295                 1300                 1305             


Ile Glu  Phe Thr Asp Ser Gly  Ile Arg Ser Thr Asp  Met Thr Tyr 
    1310                 1315                 1320             


Thr Ile  Lys Pro Asp Ile Lys  Asp Asn Lys Lys Asp  Lys Lys Val 
    1325                 1330                 1335             


Leu Val  Pro Ala Arg Ser Glu  Val Phe Leu Lys Gln  Phe Arg Lys 
    1340                 1345                 1350             


Ile Leu  Glu Tyr Arg Ile Gln  Asp Lys Ile Gln 
    1355                 1360                 


<210>  647
<211>  1358
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  647

Met Lys Ile Ser Lys Glu Gly His Lys Arg Met Ser Val Thr Leu Lys 
1               5                   10                  15      


Lys Glu Asn Met Gln Lys Asn Asp Ala Asp Lys Thr Lys Gly Gln Ile 
            20                  25                  30          


Leu Pro Leu Pro Glu Gly Glu Gly Leu Glu Lys Tyr Ile Gln Lys Arg 
        35                  40                  45              


Val Ala Asn Thr Gln Lys Leu Tyr Lys Val Leu Gly Pro Ser Ala Val 
    50                  55                  60                  


Ser Val Pro Asn Glu Lys Glu Lys Glu Thr Ile Asp Cys Phe Asn Asp 
65                  70                  75                  80  


Phe Ile Lys Asn Ile Ile Leu Lys Asn Val Asn Thr Gln Pro Ala Glu 
                85                  90                  95      


Lys Arg Asn Arg Asn Ala Val Glu Tyr Met Lys Thr Lys Gly Asn Val 
            100                 105                 110         


Asn Thr Val Phe Ile Asp Val Asp Arg Lys Cys Ile His Lys Leu Val 
        115                 120                 125             


Pro Leu His Leu Arg Gly Thr Leu Lys Lys Tyr Val Lys Ile Glu Lys 
    130                 135                 140                 


Asp Gly Gln Arg Ile Glu Val Tyr Ile Pro Asp Val Ile Glu Lys Leu 
145                 150                 155                 160 


Val Phe Ala Val Ala His Gly Thr Gln Phe Asp His Leu Ile Ala Glu 
                165                 170                 175     


Ile Glu Glu Glu Glu Leu Ile Val Cys Leu His Met Ile Phe Lys Asp 
            180                 185                 190         


Tyr Thr Lys Glu Asp Ile Ile Ala Asn Thr Ala Lys Ser Ile Glu Lys 
        195                 200                 205             


Gln Asp Val Lys Val Gln Val Leu Gly Thr Gly Glu Asp Ala Arg Leu 
    210                 215                 220                 


Gln Leu Ala Ser Ala Asp Asn Glu Lys Lys Lys Tyr Ile Phe Leu Phe 
225                 230                 235                 240 


Leu Lys Lys Phe Ala Cys Ala Val Ser Glu Lys Glu Arg Asn Asp Leu 
                245                 250                 255     


Leu Arg Glu Phe Arg Glu Leu Leu Val Leu Phe Tyr Cys Gly Thr Ala 
            260                 265                 270         


Ala Tyr Glu Glu Val Lys Glu Trp Lys Asn Gly Ile Pro Ile Trp Asp 
        275                 280                 285             


Phe Asp Phe Leu Ser Lys Met Val Ser Asp Ile Ser Trp Phe Phe Ser 
    290                 295                 300                 


Gln Glu Cys Ser Glu Lys Leu Met Glu Arg Glu Gln Leu Arg Arg Glu 
305                 310                 315                 320 


Lys Asp Lys Asp Lys Lys Arg Gln Asn Lys Ser Lys Ile Lys Asp Ile 
                325                 330                 335     


Asp Val Glu Val Lys Gly Ile Leu Ala Asn Leu Ile Thr Glu Arg Tyr 
            340                 345                 350         


Arg Glu Ser Ile Lys Leu Leu Gln Ser Leu Leu Gly Glu Glu Glu Tyr 
        355                 360                 365             


Lys Glu Lys Cys Phe Trp Leu Glu Tyr Ile Glu Asn Asp Ala Glu Lys 
    370                 375                 380                 


Ile Leu Cys Ser Lys Lys Ala Leu Thr Glu Asn Lys Leu Asp Thr Val 
385                 390                 395                 400 


Trp Leu Cys Asn Asn Thr Trp Arg Asn Phe Leu Ser Phe Leu Cys Ser 
                405                 410                 415     


Lys Ala Val Asp Met Gly Lys Ala Val Tyr His Phe Ala Met Pro Asp 
            420                 425                 430         


Leu Glu Gln Leu Glu Ser Gly Glu Pro Ile Lys Ala Gly Met Ile Lys 
        435                 440                 445             


Pro Gln Phe Gln Gln Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys 
    450                 455                 460                 


Ala Glu Glu Asn Leu Glu Arg Ser Phe Met Thr Ala Ile Ser Phe Ala 
465                 470                 475                 480 


Leu Asn Asn Phe Ser Ala Ala Val Cys Pro Pro Glu Thr Tyr Glu Lys 
                485                 490                 495     


Lys Asn Lys Glu Asp Val Leu Phe Met Gly Asp Lys Asp Leu Arg Glu 
            500                 505                 510         


Glu Met Tyr Pro Asn Ala Ser Trp His Ile Met Gln Tyr Phe Gly Gly 
        515                 520                 525             


Ile Ser Gln Trp Lys Asp Ser Cys Phe Glu Asp Ile Val Met Leu Glu 
    530                 535                 540                 


Asp Ala Asp Leu Asn Glu Glu Phe Val Leu Glu Val Lys Gly Ala Met 
545                 550                 555                 560 


Ser Leu Ile Arg Asn Ser Ala Phe His Tyr Ala Ala Ser Ala Ala Gln 
                565                 570                 575     


Gly Thr Leu Asp Lys Gly Ser Tyr Leu Val Glu Leu Phe Glu Arg Glu 
            580                 585                 590         


Arg Asp Asn Leu Gly Ser Lys Tyr Arg Lys Lys Tyr Val Ser Asn Asn 
        595                 600                 605             


Val Pro Met Phe Tyr Lys Val Glu Asp Ile Asp Arg Leu Met His Cys 
    610                 615                 620                 


Leu Tyr Gly Glu Gln Lys Val Leu Glu Ser Gln Ile Pro Ser Phe Arg 
625                 630                 635                 640 


Asn Val Ile Thr Arg Lys Ser Leu Pro Asp Ile Ile Val Lys Phe Val 
                645                 650                 655     


Lys Gly Lys Pro Tyr Gly Lys Ile Gln Lys Asn Val Glu Thr Ala Ser 
            660                 665                 670         


Lys Phe His Ser Ala Leu Tyr Phe Val Leu Lys Glu Ile Tyr Tyr Asn 
        675                 680                 685             


Gly Phe Leu Gln Glu Glu Asn Leu Met Glu Arg Phe Met Val Ser Phe 
    690                 695                 700                 


Asn Asn Glu Trp Asn Lys Val Lys Glu Ser Ser Gly Asn Lys Lys Lys 
705                 710                 715                 720 


Glu Ala Ala Met Lys Asp Phe Ser Arg Arg Ile Ser Glu Leu Gln Gln 
                725                 730                 735     


Asn Gly Lys Arg Leu Thr Phe Gly Glu Leu Cys Gln Ala Ile Met Thr 
            740                 745                 750         


Asp Tyr Asn Met Gln Asn Asn Gln Lys Lys Val Arg Leu Asn Lys Lys 
        755                 760                 765             


Asp Asn Leu Pro Asp Glu Lys Tyr Lys His Phe Lys Met Leu Leu Leu 
    770                 775                 780                 


Val Cys Leu Arg Glu Thr Phe Ile Asp Tyr Leu Lys Lys Asp Val Ala 
785                 790                 795                 800 


Gly Glu Lys Phe Asp Cys Ala Phe Leu Arg Glu Pro Gly Leu Lys Glu 
                805                 810                 815     


Asn Val Tyr Glu Asn Leu Thr Glu Glu Gln Phe Cys Lys Gly Trp Lys 
            820                 825                 830         


Ile Asp Arg Tyr Lys Asn Leu Ile Asn Glu Asn Gly Gln Tyr Asp Ser 
        835                 840                 845             


Trp Leu Ile Ser Trp Phe Ile Leu Ala His Phe Met Thr Pro Lys His 
    850                 855                 860                 


Leu Asn His Leu Cys Gly Glu Ile Lys Ser Tyr Leu Ser Tyr Val His 
865                 870                 875                 880 


Asn Ile Glu Arg Arg Arg Phe Asp Ala Met Arg Val Gln Val Glu Glu 
                885                 890                 895     


Asn Lys Glu Lys Arg Gln Lys Tyr Glu Gln Val Leu Glu Ile Leu Asn 
            900                 905                 910         


Leu Ala Ala Glu Tyr Cys Gly Gln Val Ser Asn Glu Arg Thr Asp Tyr 
        915                 920                 925             


Tyr Glu Ser Glu Glu Glu Tyr Ala Arg His Ile Ser Met Tyr Val Ala 
    930                 935                 940                 


Phe Glu Glu Lys Asn Ser Glu Arg Pro Leu Glu Glu Gln Leu Tyr Gly 
945                 950                 955                 960 


Phe Cys Asn Gln Lys Ala Asp Gly Gly Pro Ala Ser Arg Ile Gly Ile 
                965                 970                 975     


Phe Tyr Asp Gly Glu Asn Pro Ile Leu Asn Arg Asn Val Val Leu Thr 
            980                 985                 990         


Lys Leu Tyr Gly Ala Glu Arg Leu  Leu Ser Glu Cys Leu  Gln Lys Glu 
        995                 1000                 1005             


Arg Val  Thr Lys Ala Glu Ile  Glu Lys His Tyr Lys  His Thr Lys 
    1010                 1015                 1020             


Lys Leu  Glu Ala Val Phe Lys  Tyr Gly Thr Cys Lys  Asn Gln Glu 
    1025                 1030                 1035             


Gln Glu  Gln Glu Arg Arg Thr  Tyr Gln Gln Gln Lys  Asn Arg Ile 
    1040                 1045                 1050             


Glu Leu  Val Asp Ile Leu Lys  Tyr Ser Asp Leu Leu  Asn Asp Phe 
    1055                 1060                 1065             


Met Ser  Gln Leu Ile Ser Trp  Cys Tyr Leu Arg Glu  Arg Asp Arg 
    1070                 1075                 1080             


Met Tyr  Phe Gln Ile Gly Leu  His Tyr Ile Arg Leu  Tyr Tyr Gly 
    1085                 1090                 1095             


Glu Asn  Leu Val Glu Lys Asn  Ser Lys Phe Arg Val  Leu Gln Ser 
    1100                 1105                 1110             


Lys Glu  Ala Lys Ala Gly Glu  Lys Lys Gly Ile Asn  Leu Val Asp 
    1115                 1120                 1125             


Gly Ala  Val Leu Tyr Gln Ile  Ala Ala Ile Tyr Thr  Tyr Glu Tyr 
    1130                 1135                 1140             


Pro Val  Tyr Ala Leu Asp Glu  Ala Gly Asn Ala Ile  Val Ser Lys 
    1145                 1150                 1155             


Ala Ala  Lys Ile Gly Ser Thr  Thr Ala Asn Gly Ile  Asn Ala Phe 
    1160                 1165                 1170             


Trp Lys  Glu Tyr Cys Asn Glu  Asp Ala Ser Thr Tyr  Glu Val Gly 
    1175                 1180                 1185             


Leu Ser  Leu Phe Glu Asn Pro  Leu Glu Glu Lys Glu  Leu Ile Glu 
    1190                 1195                 1200             


Phe Arg  Asn Tyr Ile Asp His  Phe Lys Tyr Tyr Ser  Arg Arg Asp 
    1205                 1210                 1215             


Arg Ser  Ile Leu Asn Leu Tyr  Ser Gln Val Phe Ala  Asn Tyr Phe 
    1220                 1225                 1230             


Arg His  Asp Arg Lys Leu Lys  Lys Ser Val Thr Phe  Ile Leu Lys 
    1235                 1240                 1245             


Asn Ile  Leu Ala Arg His Phe  Ile Ile Ala Arg Thr  Val Leu Ala 
    1250                 1255                 1260             


Glu Val  Glu Val Glu Lys Lys  Asp Gly Arg Lys Asp  Lys Lys Asn 
    1265                 1270                 1275             


Pro Ile  Ile Arg Lys Tyr Ser  Gln Thr Glu Ile Arg  Ile Pro Thr 
    1280                 1285                 1290             


Glu Asn  Gly Leu Gln Ser Asp  Asp Thr Leu His Lys  Tyr Thr Lys 
    1295                 1300                 1305             


Glu Asp  Val Asp Asn Glu Tyr  Lys Lys Lys Met Asn  Asn Ser Lys 
    1310                 1315                 1320             


Gly Glu  Lys Gly Lys Ile Pro  Pro Lys Glu Gly Gly  Lys Tyr Ser 
    1325                 1330                 1335             


Ile Pro  Met Tyr Asp Glu Lys  Phe Ile Gln Arg Leu  Tyr Cys Ile 
    1340                 1345                 1350             


Leu Asn  Tyr Ala Lys 
    1355             


<210>  648
<211>  1102
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  648

Met Arg Val Ser Lys Val Lys Val Asp Asn Lys Asn Met Val Leu Met 
1               5                   10                  15      


Arg Arg Thr Thr Gly Asn Gly Ala Leu Val Tyr Glu Gly Glu Thr Ser 
            20                  25                  30          


Asn Arg Thr Ile Glu Ile Leu Pro Lys Gln Lys Ile Gln Ser Phe Ser 
        35                  40                  45              


Leu Ser Ile Glu Asn Lys Thr Leu Ile Lys Arg Asp Ser Leu Lys Gly 
    50                  55                  60                  


Thr Val Gln Lys Asn Lys Tyr Asp Val Ile Arg Ala Ile Ile Lys Tyr 
65                  70                  75                  80  


Asn Arg Phe Pro Asp Arg Ile Ser Ala Glu Glu Val Leu Pro Phe Leu 
                85                  90                  95      


Asn His Lys Phe Gln Asn Glu Ile Lys Tyr Tyr Asn Asp Asn Lys Leu 
            100                 105                 110         


His Ser Phe Leu Leu Thr Ser Leu Ile Val Glu Ala Val Lys Glu Lys 
        115                 120                 125             


Asn Pro Gln Lys Leu Gln Pro Tyr Phe Asp Trp Glu Glu Trp Tyr Ile 
    130                 135                 140                 


Ser Asn Lys Ser Asn Ala Leu Ile Lys Ser Ile Glu Asn Asn Lys Ile 
145                 150                 155                 160 


Asp Ser Glu Lys Lys Asp Ser Lys Arg Lys Lys Thr Leu Gln Thr Trp 
                165                 170                 175     


Ala Ala Glu Tyr Thr Asp Asn Gly Ser Ile Asp Leu Ser Glu Tyr His 
            180                 185                 190         


Asn Ile Tyr Asp Ile Asp Thr Leu Val Arg Ala Leu Ile Lys Ala Asp 
        195                 200                 205             


Lys Gly Glu Leu Lys Glu Asp Gly Thr Pro Lys Asn Ala Asn Ala Phe 
    210                 215                 220                 


His Arg Asn Leu Lys Arg Thr Leu Gln Asp His Gln Lys Thr Val Phe 
225                 230                 235                 240 


Gly Thr Arg Glu Ala Ser Asn Met Thr Asn Arg Glu Asn Asp Gln Leu 
                245                 250                 255     


Ala Val Tyr His Leu Glu Val Val Lys Tyr Leu Glu His Tyr Phe Ser 
            260                 265                 270         


Val Lys Ser Thr Gln Arg Arg Asn Thr Arg Ala Asp Ile Asp Tyr Tyr 
        275                 280                 285             


Leu Lys Ala Glu Thr Ile Lys Asn Ile Ile Thr Lys Gln Leu Leu Asn 
    290                 295                 300                 


Ala Val Arg Asn Tyr Leu Leu Gln Gln Gly Lys Ala Gln His His Lys 
305                 310                 315                 320 


Phe Ala Glu Ile Lys Pro Asp Ser Asn Ser Leu Thr Glu Ile Lys Arg 
                325                 330                 335     


Asn Glu Ala Phe Val Leu Asn Met Ile Asp Ala Cys Gly Phe Ala Ala 
            340                 345                 350         


Asn Asn Ile Arg Asn Ile Val Asp Ala Glu Gln Ile Asn Asp Ile Leu 
        355                 360                 365             


Ser Lys Lys Glu Tyr Val Gln Ser Leu Asp Ser Asn Arg Val Asn Asn 
    370                 375                 380                 


Gln Leu Phe Lys Phe Phe Phe Gly Thr Asp Leu Pro Glu Thr Ala Thr 
385                 390                 395                 400 


Asp Lys Val Lys Thr Leu Trp Ala Met Arg Gly Ala Val Gln Gln Ile 
                405                 410                 415     


Arg Asn Lys Val Val His Tyr Lys Gln Lys Ala Leu Asp Ala Ile Phe 
            420                 425                 430         


Asn Val Thr Asp Phe Glu Tyr Pro Ser Phe Asn Asn Ser Ile Tyr Thr 
        435                 440                 445             


Asp Thr Ile Tyr Lys Asp Cys Leu Glu Thr Glu Leu Gln Lys Leu Pro 
    450                 455                 460                 


Glu Ala Phe Ala Gln Gln Leu Lys Thr Gly Gly Ala Leu Thr Tyr Tyr 
465                 470                 475                 480 


Pro Phe Asp Asp Leu Lys Thr Leu Leu Asn Lys Val Ala Phe Ser Leu 
                485                 490                 495     


Cys Arg Ser Val Val Pro Phe Ala Pro Gly Phe Lys Lys Val Gln Lys 
            500                 505                 510         


Gln Gly Gln Asn Tyr Gln Asn Ala His Lys Glu Asn Phe Tyr Asn Leu 
        515                 520                 525             


Asp Leu Lys Ser Tyr Leu Pro Lys Glu Lys Phe Asp Glu Glu Ala Tyr 
    530                 535                 540                 


Asn Ala Arg Tyr Phe Leu Leu Lys Leu Ile Tyr Asn Asn Leu Phe Leu 
545                 550                 555                 560 


Ser Asp Phe Thr Gly Asn Arg Glu Gln Phe Ser Ala Thr Val Asn Tyr 
                565                 570                 575     


Ile Leu Lys Arg Asn Lys Lys Gln Ala Glu Asn Ser Arg Arg Pro Lys 
            580                 585                 590         


Ala Tyr Ala Phe Glu Ala Val Arg Gln Met Lys Lys Glu Glu Ser Ile 
        595                 600                 605             


Thr Ser Tyr Met Ala Tyr Ala Gln Asn Gln Leu Met Val Glu Lys Asn 
    610                 615                 620                 


Lys Lys Glu Asp Asp Lys Pro Glu Asp Ile Arg Ile Asn Phe Glu Lys 
625                 630                 635                 640 


Phe Val Leu Gln Val Phe Ile Lys Gly Phe Asp Asp Phe Leu Leu Asn 
                645                 650                 655     


Glu Lys Phe Lys Phe Ile Ala Thr Pro Cys Phe Gln Leu Ser Lys Glu 
            660                 665                 670         


Asn Thr Lys Gln Gln Gln Ala Asp Val Leu Asn Gln Phe Glu Gln Arg 
        675                 680                 685             


Ile Ile Lys Glu Cys Arg Phe Gln Ser His Thr Ile Lys Ala Glu Glu 
    690                 695                 700                 


Ala Lys His Val Ala Phe Phe Thr Phe Cys Lys Leu Leu Asp Ala Thr 
705                 710                 715                 720 


His Leu Ser Asn Leu Arg Asn Glu Leu Ile Lys Phe Lys Gln Ser Ser 
                725                 730                 735     


Lys Gln Phe Glu Leu Cys His Val Leu Glu Ile Ile Glu Leu Ser Leu 
            740                 745                 750         


Leu Asn Ala Asp Val Val Pro Ala Asp Tyr Arg Glu Leu Tyr Ala Asn 
        755                 760                 765             


Lys Val Thr Cys Leu Asn Arg Val Arg Pro Phe Ile Ala Asp Gly Val 
    770                 775                 780                 


Asp Ile Thr Lys Trp Ser Gly Leu Phe Ile Gln Thr Asp Asn Glu Thr 
785                 790                 795                 800 


Pro Val Ile His Ala Asn Val Glu Leu Thr Val Lys Tyr Gly Thr Thr 
                805                 810                 815     


Lys Leu Leu Glu Gln Leu Ile Ala Lys Gly Ala Ser Phe Lys Leu Ser 
            820                 825                 830         


Glu Ser Asp Phe Asn Leu Trp Asn Ser Ala Lys Asp Thr Ile Lys Glu 
        835                 840                 845             


Val Ile Asn Lys Arg Leu Ser Leu His Lys Gln Trp Glu Asp Ala Ile 
    850                 855                 860                 


Arg Lys Asp Lys Glu Glu Lys Asn Lys Arg Val Lys Thr Arg Ser Asn 
865                 870                 875                 880 


Phe Ala Gln Gln Phe Ile Asn Lys Glu Arg Asp Ser Tyr Phe Asp Leu 
                885                 890                 895     


Cys Asp Tyr Ile Asp Ala Tyr Asn Trp Tyr Asp Ser Lys Leu His Phe 
            900                 905                 910         


Val Asn Leu Ile Arg Leu His His Leu Thr Ile Asp Ile Leu Gly Arg 
        915                 920                 925             


Met Val Gly Phe Val Ala Ile Trp Glu Arg Asp Phe Gln Tyr Met Thr 
    930                 935                 940                 


Glu Ser Ile Ser Pro Met Asn Ser Ser Lys Glu Leu Asp Phe Thr Lys 
945                 950                 955                 960 


Gly Phe Pro Leu Leu Lys Gly Ile Gln Leu Asp Tyr Tyr Lys Arg Ile 
                965                 970                 975     


Phe Leu Ser Gly Asn Tyr Arg Asp Ile Arg Asn Tyr Ile Ala His Phe 
            980                 985                 990         


Asn Tyr Leu Thr Asp Ser Lys Phe  Ser Met Ile Asp Leu  Ile Asn Glu 
        995                 1000                 1005             


Leu Arg  Glu Leu Leu Ser Tyr  Asp Arg Lys Leu Lys  Asn Ala Val 
    1010                 1015                 1020             


Asn Lys  Ala Phe Ile Asp Leu  Phe Asp Lys Gln Gly  Met Val Leu 
    1025                 1030                 1035             


Lys Leu  Lys Leu Asn Asp Ala  His Arg Phe Glu Ile  Glu Ser Val 
    1040                 1045                 1050             


Glu Pro  Lys Leu Leu Tyr His  Leu Gly Thr Thr Pro  Ala Arg Asp 
    1055                 1060                 1065             


Pro Ile  Ser Thr Tyr Gln Val  Lys Pro Gln Tyr Cys  Asp Met Cys 
    1070                 1075                 1080             


Lys Ala  Leu Leu Glu Ile Lys  Asn Ser Ser Arg Leu  Asn Asn Val 
    1085                 1090                 1095             


Ile Ile  Ser Leu 
    1100         


<210>  649
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  649

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Asn Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  650
<211>  1418
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  650

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Leu Tyr Gln Ile Val  Ser Ala Phe Asn Phe  Gly Ser Lys 
    1205                 1210                 1215             


Leu Leu  Tyr Ile Ser Glu Asp  Gly Arg Trp Lys Met  Ala Gly Gly 
    1220                 1225                 1230             


Ala Phe  Pro Gly Lys Tyr Gly  Arg Phe Glu Asn Asp  Tyr Asn His 
    1235                 1240                 1245             


Arg Thr  Ser Leu Ser Lys Val  Ile Arg Leu Phe Glu  Asn Glu Ser 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ile Ile Tyr  Trp Arg Asp Tyr Val  Asp His Met 
    1265                 1270                 1275             


Lys Tyr  Tyr Val Asn Gln Asn  Gln Ser Ile Met Glu  Ile Tyr Ser 
    1280                 1285                 1290             


Ala Phe  Tyr Ser Lys Val Leu  Gly Tyr Ser Ala Lys  Leu Arg Lys 
    1295                 1300                 1305             


Ser Val  Val Phe Asn Leu Gln  Ala Ala Leu Glu Lys  His His Ile 
    1310                 1315                 1320             


Asn Pro  Glu Cys Ile Trp Met  Thr Ser Asp Gly Lys  Cys Ala Asp 
    1325                 1330                 1335             


Ile Lys  Leu Met Lys Asn Leu  Glu Ser Gln Lys Phe  Thr Tyr Lys 
    1340                 1345                 1350             


Leu Ala  Lys Arg Glu Gly Glu  Lys Thr Glu Arg Lys  Ile Cys Met 
    1355                 1360                 1365             


Asn Ala  Leu Asn Glu Asn Phe  Leu Lys Thr Ile Lys  Asp Gly Thr 
    1370                 1375                 1380             


His Glu  Asn Ser Phe Ile Ile  Ala Glu Ile Lys Ile  Phe Phe Glu 
    1385                 1390                 1395             


Pro Val  Leu Asp Ala Ile Val  Asn Lys Lys Asp Gly  Gly Lys Ile 
    1400                 1405                 1410             


Asn Val  Ile Ile Tyr 
    1415             


<210>  651
<211>  1167
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  651

Met Lys Val Thr Lys Val Gly Gly Ile Ser His Lys Lys Tyr Thr Ser 
1               5                   10                  15      


Glu Gly Arg Leu Val Lys Ser Glu Ser Glu Glu Asn Arg Thr Asp Glu 
            20                  25                  30          


Arg Leu Ser Ala Leu Leu Asn Met Arg Leu Asp Met Tyr Ile Lys Asn 
        35                  40                  45              


Pro Ser Asn Thr Glu Thr Lys Glu Asn Lys Lys Arg Ile Gly Lys Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Met Val Tyr Leu Lys Asp Asn Thr Leu 
65                  70                  75                  80  


Ser Leu Lys Asn Gly Lys Lys Glu Asn Ile Asp Arg Glu Tyr Ser Glu 
                85                  90                  95      


Thr Asp Ile Ser Glu Tyr Asp Val Arg Asp Ser Lys Asn Phe Ala Val 
            100                 105                 110         


Leu Lys Lys Ile Tyr Leu Asn Glu Asn Val Asn Ser Glu Glu Leu Glu 
        115                 120                 125             


Val Phe Arg Lys Asp Ile Lys Lys Lys Leu Asn Lys Ile Asn Ser Leu 
    130                 135                 140                 


Lys Tyr Ser Phe Glu Lys Asn Lys Ala Asn Tyr Gln Lys Ile Asn Glu 
145                 150                 155                 160 


Asn Asn Ile Glu Lys Val Glu Gly Lys Ser Lys Arg Asn Ile Ile Tyr 
                165                 170                 175     


Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asp Ala Tyr Val Ser Asn Val 
            180                 185                 190         


Lys Glu Ala Phe Asp Lys Leu Tyr Lys Glu Glu Asp Ile Ala Lys Leu 
        195                 200                 205             


Val Leu Lys Ile Glu Asn Leu Thr Lys Leu Glu Lys Ser Lys Ile Arg 
    210                 215                 220                 


Glu Phe Tyr His Glu Ile Ile Gly Arg Lys Asn Asp Lys Glu Asn Phe 
225                 230                 235                 240 


Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Met Lys Glu 
                245                 250                 255     


Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser Gln Val 
            260                 265                 270         


Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Glu Asn Val 
        275                 280                 285             


Lys Tyr Val Phe Cys His Phe Val Glu Ile Glu Met Ser Lys Leu Leu 
    290                 295                 300                 


Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp Lys Val 
305                 310                 315                 320 


Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu Asn Lys 
                325                 330                 335     


Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys Tyr Asn 
            340                 345                 350         


Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile Ala Arg 
        355                 360                 365             


Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val Ser Ser 
    370                 375                 380                 


Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn Lys Asp 
385                 390                 395                 400 


Asp Ile Thr Gly Lys Met Arg Gly Lys Thr Arg Ile Glu Ser Lys Thr 
                405                 410                 415     


Gly Glu Glu Lys Tyr Ile Pro Gly Glu Val Asp Gln Ile Tyr Tyr Glu 
            420                 425                 430         


Asn Lys Gln Asn Glu Val Lys Asn Lys Leu Lys Met Phe Tyr Gly Tyr 
        435                 440                 445             


Asp Phe Asp Met Asp Asn Lys Lys Glu Ile Glu Asp Phe Phe Ala Asn 
    450                 455                 460                 


Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe Asn 
465                 470                 475                 480 


Leu Asp Leu Asp Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Val Pro 
                485                 490                 495     


Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys Lys 
            500                 505                 510         


Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe Arg 
        515                 520                 525             


Tyr Leu Glu Lys Asp Arg Ile Leu Asp Tyr Leu Arg Ser Thr Arg Phe 
    530                 535                 540                 


Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys Leu 
545                 550                 555                 560 


Tyr Asp Arg Ile Asp Asp Leu Lys Ile Ser Leu Asn Ile Tyr Trp Lys 
                565                 570                 575     


Thr Pro Lys Thr Asn Asp Asp Ile Lys Thr Lys Glu Ile Thr Asp Ala 
            580                 585                 590         


Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Lys Phe Leu Asp Tyr 
        595                 600                 605             


Phe Met Ser Arg Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Val Ile 
    610                 615                 620                 


Lys Leu Asn Lys Asn Asn Lys Lys Asn Val Lys Thr Gly Phe Tyr Lys 
625                 630                 635                 640 


Leu Gln Lys Phe Glu Asn Leu Glu Ala Arg Ser Pro Lys Glu Tyr Leu 
                645                 650                 655     


Ala Lys Val Gln Ser Leu Tyr Ile Ile Asn Val Ala Asn Gln Asp Glu 
            660                 665                 670         


Glu Glu Lys Asn Thr Tyr Ile Asp Phe Ile Gln Lys Val Phe Leu Lys 
        675                 680                 685             


Gly Phe Ile Thr Tyr Leu Ala Asn Asn Arg Arg Leu Ser Leu Met Tyr 
    690                 695                 700                 


Ile Gly Ser Asp Glu Glu Val Asn Asn Ser Leu Ala Glu Lys Lys Gln 
705                 710                 715                 720 


Glu Phe Asp Lys Phe Trp Arg Lys Tyr Glu Glu Asn Asn Asp Ile Glu 
                725                 730                 735     


Ile Pro Asp Glu Ile Asn Glu Phe Leu Lys Glu Ile Lys Leu Gly Lys 
            740                 745                 750         


Ile Leu Lys Asn Ser Ala Lys Leu Asn Ile Phe Tyr Leu Ile Leu Lys 
        755                 760                 765             


Leu Leu Asn Asn Lys Glu Phe Thr Asn Leu Lys Gly Asn Leu Glu Lys 
    770                 775                 780                 


Tyr His Ser Ala Asn Glu Val Asn Ile Phe Ser Asp Glu Leu Glu Leu 
785                 790                 795                 800 


Ile Asn Phe Leu Asn Leu Asp Asn Asn Lys Val Lys Glu Asp Phe Glu 
                805                 810                 815     


Phe Glu Ala Asp Glu Ile Gly Lys Phe Leu Asn Phe Asn Gly Asn Lys 
            820                 825                 830         


Ile Lys Asn Arg Glu Glu Leu Lys Lys Phe Asp Thr Thr Lys Met Tyr 
        835                 840                 845             


Phe Tyr Lys Glu Asn Ile Ile Lys Tyr Arg Ala Tyr Tyr Asn Ile Lys 
    850                 855                 860                 


Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala Gly 
865                 870                 875                 880 


Tyr Lys Ile Ser Ile Glu Glu Leu Lys Lys Tyr Ser Asn Lys Lys Asn 
                885                 890                 895     


Glu Ile Glu Lys Asn His Lys Met Gln Glu Asn Leu His Arg Lys Tyr 
            900                 905                 910         


Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Glu Ser 
        915                 920                 925             


Tyr Lys Gln Ala Ile Lys Asn Ile Glu Glu Tyr Thr His Leu Lys Asn 
    930                 935                 940                 


Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu Arg 
945                 950                 955                 960 


Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp Leu 
                965                 970                 975     


Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu Glu 
            980                 985                 990         


Ile Phe Asn Phe Glu Asn Lys Lys  Asn Met Lys Tyr Lys  Ser Gly Gln 
        995                 1000                 1005             


Ile Val  Glu Lys Tyr Ile Lys  Phe Tyr Lys Glu Leu  His Gln Asn 
    1010                 1015                 1020             


Asp Glu  Val Lys Ile Asn Lys  Tyr Ser Ser Ala Asn  Ile Lys Val 
    1025                 1030                 1035             


Leu Lys  Gln Glu Lys Lys Asp  Leu Tyr Ile Arg Asn  Tyr Ile Ala 
    1040                 1045                 1050             


His Phe  Asn Tyr Ile Pro His  Ala Glu Ile Ser Leu  Leu Glu Val 
    1055                 1060                 1065             


Leu Glu  Asn Leu Arg Lys Leu  Leu Ser Tyr Asp Arg  Lys Leu Lys 
    1070                 1075                 1080             


Asn Ala  Val Met Lys Ser Val  Val Asp Ile Leu Lys  Glu Tyr Gly 
    1085                 1090                 1095             


Phe Val  Val Lys Phe Lys Ile  Gly Ala Asp Lys Lys  Ile Glu Ile 
    1100                 1105                 1110             


Gln Ser  Leu Lys Ser Glu Glu  Ile Val His Leu Lys  Lys Leu Lys 
    1115                 1120                 1125             


Leu Lys  Asp Asn Asp Lys Lys  Lys Glu Pro Ile Lys  Thr Tyr Arg 
    1130                 1135                 1140             


Asn Ser  Lys Glu Leu Cys Lys  Leu Val Lys Val Met  Phe Glu Tyr 
    1145                 1150                 1155             


Lys Met  Glu Glu Lys Ser Ser  Glu Lys 
    1160                 1165         


<210>  652
<211>  1102
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  652

Met Arg Val Ser Lys Val Lys Val Asp Asn Lys Asn Met Val Leu Met 
1               5                   10                  15      


Arg Arg Thr Thr Gly Asn Gly Ala Leu Val Tyr Glu Gly Glu Thr Ser 
            20                  25                  30          


Asn Arg Thr Ile Glu Ile Leu Pro Lys Gln Lys Ile Gln Ser Phe Ser 
        35                  40                  45              


Leu Ser Ile Glu Asn Lys Thr Leu Ile Lys Arg Asp Ser Leu Lys Gly 
    50                  55                  60                  


Thr Val Gln Lys Asn Lys Tyr Asp Val Ile Arg Ala Ile Ile Lys Tyr 
65                  70                  75                  80  


Asn Arg Phe Pro Asp Arg Ile Ser Ala Glu Glu Val Leu Pro Phe Leu 
                85                  90                  95      


Asn His Lys Phe Gln Asn Glu Ile Lys Tyr Tyr Asn Asp Asn Lys Leu 
            100                 105                 110         


His Ser Phe Leu Leu Thr Ser Leu Ile Val Glu Ala Val Lys Glu Lys 
        115                 120                 125             


Asn Pro Gln Lys Leu Gln Pro Tyr Phe Asp Trp Glu Glu Trp Tyr Ile 
    130                 135                 140                 


Ser Asn Lys Ser Asn Ala Leu Ile Lys Ser Ile Glu Asn Asn Lys Ile 
145                 150                 155                 160 


Asp Ser Glu Lys Lys Asp Ser Lys Arg Lys Lys Thr Leu Gln Thr Trp 
                165                 170                 175     


Ala Ala Glu Tyr Thr Asp Asn Gly Ser Ile Asp Leu Ser Glu Tyr His 
            180                 185                 190         


Asn Ile Tyr Asp Ile Asp Thr Leu Val Arg Ala Leu Ile Lys Ala Asp 
        195                 200                 205             


Lys Gly Glu Leu Lys Glu Asp Gly Thr Pro Lys Asn Ala Asn Ala Phe 
    210                 215                 220                 


His Arg Asn Leu Lys Arg Thr Leu Gln Asp His Gln Lys Thr Val Phe 
225                 230                 235                 240 


Gly Thr Arg Glu Ala Ser Asn Met Thr Asn Arg Glu Asn Asp Gln Leu 
                245                 250                 255     


Ala Val Tyr His Leu Glu Val Val Lys Tyr Leu Glu His Tyr Phe Ser 
            260                 265                 270         


Val Lys Ser Thr Gln Arg Arg Asn Thr Arg Ala Asp Ile Asp Tyr Tyr 
        275                 280                 285             


Leu Lys Ala Glu Thr Ile Lys Asn Ile Ile Thr Lys Gln Leu Leu Asn 
    290                 295                 300                 


Ala Val Arg Asn Tyr Leu Leu Gln Gln Gly Lys Ala Gln His His Lys 
305                 310                 315                 320 


Phe Ala Glu Ile Lys Pro Asp Ser Asn Ser Leu Thr Glu Ile Lys Arg 
                325                 330                 335     


Asn Glu Ala Phe Val Leu Asn Met Ile Asp Ala Cys Gly Phe Ala Ala 
            340                 345                 350         


Asn Asn Ile Arg Asn Ile Val Asp Ala Glu Gln Ile Asn Asp Ile Leu 
        355                 360                 365             


Ser Lys Lys Glu Tyr Val Gln Ser Leu Asp Ser Asn Arg Val Asn Asn 
    370                 375                 380                 


Gln Leu Phe Lys Phe Phe Phe Gly Thr Asp Leu Pro Glu Thr Ala Thr 
385                 390                 395                 400 


Asp Lys Val Lys Thr Leu Trp Ala Met Arg Gly Ala Val Gln Gln Ile 
                405                 410                 415     


Arg Asn Lys Val Val His Tyr Lys Gln Lys Ala Leu Asp Ala Ile Phe 
            420                 425                 430         


Asn Val Thr Asp Phe Glu Tyr Pro Ser Phe Asn Asn Ser Ile Tyr Thr 
        435                 440                 445             


Asp Thr Ile Tyr Lys Asp Cys Leu Glu Thr Glu Leu Gln Lys Leu Pro 
    450                 455                 460                 


Glu Ala Phe Ala Gln Gln Leu Lys Thr Gly Gly Ala Leu Thr Tyr Tyr 
465                 470                 475                 480 


Pro Phe Asp Asp Leu Lys Thr Leu Leu Asn Lys Val Ala Phe Ser Leu 
                485                 490                 495     


Cys Arg Ser Val Val Pro Phe Ala Pro Gly Phe Lys Lys Val Gln Lys 
            500                 505                 510         


Gln Gly Gln Asn Tyr Gln Asn Ala His Lys Glu Asn Phe Tyr Asn Leu 
        515                 520                 525             


Asp Leu Lys Ser Tyr Leu Pro Lys Glu Lys Phe Asp Glu Glu Ala Tyr 
    530                 535                 540                 


Asn Ala Arg Tyr Phe Leu Leu Lys Leu Ile Tyr Asn Asn Leu Phe Leu 
545                 550                 555                 560 


Ser Asp Phe Thr Gly Asn Arg Glu Gln Phe Ser Ala Thr Val Asn Tyr 
                565                 570                 575     


Ile Leu Lys Arg Asn Lys Lys Gln Ala Glu Asn Ser Arg Arg Pro Lys 
            580                 585                 590         


Ala Tyr Ala Phe Glu Ala Val Arg Gln Met Lys Lys Glu Glu Ser Ile 
        595                 600                 605             


Thr Ser Tyr Met Ala Tyr Ala Gln Asn Gln Leu Met Val Glu Lys Asn 
    610                 615                 620                 


Lys Lys Glu Asp Asp Lys Pro Glu Asp Ile Arg Ile Asn Phe Glu Lys 
625                 630                 635                 640 


Phe Val Leu Gln Val Phe Ile Lys Gly Phe Asp Asp Phe Leu Leu Asn 
                645                 650                 655     


Glu Lys Phe Lys Phe Ile Ala Thr Pro Cys Phe Gln Leu Ser Lys Glu 
            660                 665                 670         


Asn Thr Lys Gln Gln Gln Ala Asp Val Leu Asn Gln Phe Glu Gln Arg 
        675                 680                 685             


Ile Ile Lys Glu Cys Arg Phe Gln Ser His Thr Ile Lys Ala Glu Glu 
    690                 695                 700                 


Ala Lys His Val Ala Phe Phe Thr Phe Cys Lys Leu Leu Asp Ala Thr 
705                 710                 715                 720 


His Leu Ser Asn Leu Arg Asn Glu Leu Ile Lys Phe Lys Gln Ser Ser 
                725                 730                 735     


Lys Gln Phe Glu Leu Cys His Val Leu Glu Ile Ile Glu Leu Ser Leu 
            740                 745                 750         


Leu Asn Ala Asp Val Val Pro Ala Asp Tyr Arg Glu Leu Tyr Ala Asn 
        755                 760                 765             


Lys Val Thr Cys Leu Asn Arg Val Arg Pro Phe Ile Ala Asp Gly Val 
    770                 775                 780                 


Asp Ile Thr Lys Trp Ser Gly Leu Phe Ile Gln Thr Asp Asn Glu Thr 
785                 790                 795                 800 


Pro Val Ile His Ala Asn Val Glu Leu Thr Val Lys Tyr Gly Thr Thr 
                805                 810                 815     


Lys Leu Leu Glu Gln Leu Ile Ala Lys Gly Ala Ser Phe Lys Leu Ser 
            820                 825                 830         


Glu Ser Asp Phe Asn Leu Trp Asn Ser Ala Lys Asp Thr Ile Lys Glu 
        835                 840                 845             


Val Ile Asn Lys Arg Leu Ser Leu His Lys Gln Trp Glu Asp Ala Ile 
    850                 855                 860                 


Arg Lys Asp Lys Glu Glu Lys Asn Lys Arg Val Lys Thr Arg Ser Asn 
865                 870                 875                 880 


Phe Ala Gln Gln Phe Ile Asn Lys Glu Arg Asp Ser Tyr Phe Asp Leu 
                885                 890                 895     


Cys Asp Tyr Ile Asp Ala Tyr Asn Trp Tyr Asp Ser Lys Leu His Phe 
            900                 905                 910         


Val Asn Leu Ile Arg Leu His His Leu Thr Ile Asp Ile Leu Gly Arg 
        915                 920                 925             


Met Val Gly Phe Val Ala Ile Trp Glu Arg Asp Phe Gln Tyr Met Thr 
    930                 935                 940                 


Glu Ser Ile Ser Pro Met Asn Ser Ser Lys Glu Leu Asp Phe Thr Lys 
945                 950                 955                 960 


Gly Phe Pro Leu Leu Lys Gly Ile Gln Leu Asp Tyr Tyr Lys Arg Ile 
                965                 970                 975     


Phe Leu Ser Gly Asn Tyr Arg Asp Ile Arg Asn Tyr Ile Ala His Phe 
            980                 985                 990         


Asn Tyr Leu Thr Asp Ser Lys Phe  Ser Met Ile Asp Leu  Ile Asn Glu 
        995                 1000                 1005             


Leu Arg  Glu Leu Leu Ser Tyr  Asp Arg Lys Leu Lys  Asn Ala Val 
    1010                 1015                 1020             


Asn Lys  Ala Phe Ile Asp Leu  Phe Asp Lys Gln Gly  Met Val Leu 
    1025                 1030                 1035             


Lys Leu  Lys Leu Asn Asp Ala  His Arg Phe Glu Ile  Glu Ser Val 
    1040                 1045                 1050             


Glu Pro  Lys Leu Leu Tyr His  Leu Gly Thr Thr Pro  Ala Arg Asp 
    1055                 1060                 1065             


Pro Ile  Ser Thr Tyr Gln Val  Lys Pro Gln Tyr Cys  Asp Met Cys 
    1070                 1075                 1080             


Lys Ala  Leu Leu Glu Ile Lys  Asn Ser Ser Arg Leu  Asn Asn Val 
    1085                 1090                 1095             


Ile Ile  Ser Leu 
    1100         


<210>  653
<211>  1225
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  653

Met Lys Ile Thr Lys Arg Lys Trp Gly Glu His His Pro Pro Leu Tyr 
1               5                   10                  15      


Phe Tyr Arg Asp Glu Asp Ser Gly Arg Leu Leu Ala Gln Asn Asp Arg 
            20                  25                  30          


Lys Gln Asp Tyr Thr Asp Thr Leu Phe Asn Asp Ile Ala Gln Asp Thr 
        35                  40                  45              


Phe Glu Arg Ser Leu Arg Asn Arg Leu Leu Lys Thr Pro Glu Lys Gly 
    50                  55                  60                  


Asp Lys Arg Phe Tyr Ser Asn Glu Ile Val Lys Leu Val Glu Lys Leu 
65                  70                  75                  80  


Cys Gln Gly Ala Asp Val Ala Glu Ile Met Lys Ser Met Glu Arg Ser 
                85                  90                  95      


Glu Lys Leu Arg Pro Lys Asn Glu Lys Glu Ile Lys Asn Leu Lys Lys 
            100                 105                 110         


Gln Leu Tyr Gly Thr Leu Ser Glu Tyr Gly Lys Arg Tyr Thr Ala Pro 
        115                 120                 125             


Glu Gly Ala Met Thr Leu Asn Asp Ala Leu Phe Tyr Leu Val Glu Gly 
    130                 135                 140                 


Asn Pro Leu Lys Gln Ala Met Ala Lys Ala Glu Leu Gly Lys Ile Arg 
145                 150                 155                 160 


Glu Ala Leu Ile Lys Glu Lys Glu Asn Arg Ile Asn Arg Val Arg Tyr 
                165                 170                 175     


Ser Ile Lys Asn Asn Lys Ile Pro Leu Arg Ile Gln Glu Asp Gly Gly 
            180                 185                 190         


Ile Thr Pro Asn Asn Asp Arg Ala Ala Trp Leu Leu Gly Leu Met Lys 
        195                 200                 205             


Pro Ala Asp Pro Ala Lys Gly Ile Thr Asp Cys Tyr Pro Leu Leu Gly 
    210                 215                 220                 


Glu Leu Glu Glu Val Phe Asp Phe Asp Lys Leu Ser Lys Thr Leu His 
225                 230                 235                 240 


Glu Lys Ile Ser Arg Cys Gln Gly Arg Pro Arg Ser Ile Ala Met Ala 
                245                 250                 255     


Val Asp Glu Ala Leu Lys Gln Tyr Leu Arg Glu Leu Trp Glu Lys Ser 
            260                 265                 270         


Pro Ser Arg Gln Gln Asp Leu Lys Tyr Tyr Phe Gln Ala Val Gln Glu 
        275                 280                 285             


Tyr Phe Lys Asp Asn Phe Pro Ile Arg Thr Lys Arg Met Gly Ala Arg 
    290                 295                 300                 


Leu Arg Gln Glu Leu Leu Lys Asp Lys Thr Ser Leu Ser Arg Leu Leu 
305                 310                 315                 320 


Glu Pro Lys His Met Ala Asn Ala Val Arg Arg Arg Leu Ile Asn Gln 
                325                 330                 335     


Ser Thr Gln Met His Ile Leu Tyr Gly Lys Leu Tyr Ala Tyr Cys Cys 
            340                 345                 350         


Gly Glu Asp Gly Arg Leu Leu Val Asn Ser Glu Thr Leu Gln Arg Ile 
        355                 360                 365             


Gln Val His Glu Ala Val Lys Lys Gln Ala Met Thr Ala Val Leu Trp 
    370                 375                 380                 


Ser Ile Ser Arg Leu Arg Tyr Phe Tyr Gln Phe Glu Asp Gly Asp Ile 
385                 390                 395                 400 


Leu Ser Asn Lys Asn Pro Ile Lys Asp Phe Arg Asp Lys Phe Leu Arg 
                405                 410                 415     


Asp Thr Asn Lys Tyr Thr His Glu Asp Val Glu Ala Cys Lys Glu Lys 
            420                 425                 430         


Leu Gln Asp Phe Phe Pro Leu Lys Glu Leu Gln Glu Lys Ile Lys Glu 
        435                 440                 445             


Asp Ala Lys Gly Leu Gln Glu Thr Asp Asn Lys Gln Ala Asp Thr Thr 
    450                 455                 460                 


Asp Phe Lys Ala Ile Gly His Ile Val Arg Asp Asp Arg Lys Leu Cys 
465                 470                 475                 480 


Asn Gln Leu Leu Ala Glu Cys Val Ser Cys Ile Gly Glu Leu Arg His 
                485                 490                 495     


His Ile Phe His Tyr Lys Asn Val Thr Leu Ile Gln Ala Leu Lys Arg 
            500                 505                 510         


Ile Ala Asp Lys Val Lys Pro Glu Asp Leu Ser Val Leu Arg Ala Ile 
        515                 520                 525             


Tyr Leu Leu Asp Arg Arg Asn Leu Lys Lys Ala Phe Ala Lys Arg Ile 
    530                 535                 540                 


Ser Ser Met Asn Leu Pro Leu Tyr Tyr Arg Glu Asp Leu Leu Ser Arg 
545                 550                 555                 560 


Ile Phe Lys Lys Glu Gly Thr Ala Phe Phe Leu Tyr Ser Ala Lys Ile 
                565                 570                 575     


Gln Met Thr Pro Ser Phe Gln Arg Val Tyr Glu Arg Gly Lys Asn Leu 
            580                 585                 590         


Arg Arg Glu Phe Glu Cys Glu Arg Met Lys Ala Glu Ala Ser Asn Gly 
        595                 600                 605             


Gln Asn Gly Gln Asp Gly Asp Arg Leu Lys Trp Phe Arg Gln Leu Ala 
    610                 615                 620                 


Ala Gly Asp Ser Ala Asp Thr His Phe Asn Trp Ala Val Glu Ala Tyr 
625                 630                 635                 640 


Ala Glu Ser Ala Ala Asp Val Glu Asn Asn Val Glu Phe Asp Thr Asp 
                645                 650                 655     


Val Asp Ala Gln Arg Ala Leu Arg Asn Leu Leu Leu Leu Ile Tyr Arg 
            660                 665                 670         


His His Phe Leu Pro Glu Val Gln Lys Asp Glu Thr Leu Val Thr Gly 
        675                 680                 685             


Lys Ile His Lys Val Leu Glu Arg Asn Arg Gln Leu Ser Glu Gly Gln 
    690                 695                 700                 


Gly Pro Asn Gln Gly Lys Ala His Gly Tyr Ser Val Ile Glu Glu Leu 
705                 710                 715                 720 


Tyr His Glu Gly Met Pro Leu Ser Asp Leu Met Lys Gln Leu Gln Arg 
                725                 730                 735     


Arg Ile Ser Glu Thr Glu Arg Glu Ser Arg Glu Leu Ala Gln Glu Lys 
            740                 745                 750         


Thr Asp Tyr Ala Gln Arg Phe Ile Leu Asp Ile Phe Ala Glu Ala Phe 
        755                 760                 765             


Asn Asp Phe Leu Glu Ala His Tyr Gly Glu Glu Tyr Leu Glu Ile Met 
    770                 775                 780                 


Ser Pro Arg Lys Asp Ala Glu Ala Ala Lys Lys Trp Val Lys Glu Ser 
785                 790                 795                 800 


Lys Thr Val Asp Leu Lys Thr Ser Ile Asp Glu Lys Glu Pro Glu Gly 
                805                 810                 815     


His Leu Leu Val Leu Tyr Pro Val Leu Arg Leu Leu Asp Glu Arg Glu 
            820                 825                 830         


Leu Gly Glu Leu Gln Gln Gln Met Ile Arg Tyr Arg Thr Ser Leu Ala 
        835                 840                 845             


Ser Trp Gln Gly Glu Ser Asn Phe Ser Glu Glu Ile Arg Ile Ala Gly 
    850                 855                 860                 


Gln Ile Glu Glu Leu Thr Glu Leu Val Lys Leu Thr Glu Pro Glu Pro 
865                 870                 875                 880 


Gln Phe Ala Glu Glu Val Trp Gly Lys Arg Ala Lys Glu Ala Phe Glu 
                885                 890                 895     


Asp Phe Ile Glu Gly Asn Met Lys Asn Tyr Glu Ala Phe Tyr Leu Gln 
            900                 905                 910         


Ser Asp Asn Asn Thr Pro Val Tyr Arg Arg Asn Met Ser Arg Leu Leu 
        915                 920                 925             


Arg Ser Gly Leu Met Gly Val Tyr Gln Lys Val Leu Ala Ser His Lys 
    930                 935                 940                 


Gln Ala Leu Lys Arg Asp Tyr Leu Leu Trp Ser Glu Lys His Trp Asn 
945                 950                 955                 960 


Val Lys Asp Glu Asn Gly Ala Asp Ile Ser Ser Ala Glu Gln Ala Gln 
                965                 970                 975     


Cys Leu Leu Gln Arg Leu His Arg Lys Tyr Ala Glu Ser Pro Ser Arg 
            980                 985                 990         


Phe Thr Glu Glu Asp Cys Lys Leu  Tyr Glu Lys Val Leu  Arg Arg Leu 
        995                 1000                 1005             


Glu Asp  Tyr Asn Gln Ala Val  Lys Asn Leu Ser Phe  Ser Ser Leu 
    1010                 1015                 1020             


Tyr Glu  Ile Cys Val Leu Asn  Leu Glu Ile Leu Ser  Arg Trp Val 
    1025                 1030                 1035             


Gly Phe  Val Gln Asp Trp Glu  Arg Asp Met Tyr Phe  Leu Leu Leu 
    1040                 1045                 1050             


Ala Trp  Val Arg Gln Gly Lys  Leu Asp Gly Ile Lys  Glu Glu Asp 
    1055                 1060                 1065             


Val Arg  Asp Ile Phe Ser Glu  Gly Asn Ile Ile Arg  Asn Leu Val 
    1070                 1075                 1080             


Asp Thr  Leu Lys Gly Glu Asn  Met Asn Ala Phe Glu  Ser Val Tyr 
    1085                 1090                 1095             


Phe Pro  Glu Asn Lys Gly Ser  Lys Tyr Leu Gly Val  Arg Asn Asp 
    1100                 1105                 1110             


Val Ala  His Leu Asp Leu Met  Arg Lys Asn Gly Trp  Arg Leu Glu 
    1115                 1120                 1125             


Ala Gly  Lys Thr Cys Ser Val  Met Glu Asp Tyr Ile  Asn Arg Leu 
    1130                 1135                 1140             


Arg Phe  Leu Leu Ser Tyr Asp  Gln Lys Arg Met Asn  Ala Val Thr 
    1145                 1150                 1155             


Lys Thr  Leu Gln Gln Ile Phe  Asp Arg His Lys Val  Lys Ile Arg 
    1160                 1165                 1170             


Phe Thr  Val Glu Lys Gly Gly  Met Leu Lys Ile Glu  Asp Val Thr 
    1175                 1180                 1185             


Ala Asp  Lys Ile Ala His Leu  Lys Gly Ser Arg Leu  Ser Gly Ile 
    1190                 1195                 1200             


Glu Ile  Leu Ser His Gly Glu  Arg Phe Ile Asp Thr  Leu Lys Ala 
    1205                 1210                 1215             


Leu Met  Val Tyr Pro Arg Gly  
    1220                 1225 


<210>  654
<211>  1225
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  654

Met Lys Ile Thr Lys Arg Lys Trp Gly Glu His His Pro Pro Leu Tyr 
1               5                   10                  15      


Phe Tyr Arg Asp Glu Asp Ser Gly Arg Leu Leu Ala Gln Asn Asp Arg 
            20                  25                  30          


Lys Gln Asp Tyr Thr Asp Thr Leu Phe Asn Asp Ile Ala Gln Asp Thr 
        35                  40                  45              


Phe Glu Arg Ser Leu Arg Asn Arg Leu Leu Lys Thr Pro Glu Lys Gly 
    50                  55                  60                  


Asp Lys Arg Phe Tyr Ser Asn Glu Ile Val Lys Leu Val Glu Lys Leu 
65                  70                  75                  80  


Cys Gln Gly Ala Asp Val Ala Glu Ile Met Lys Ser Met Glu Arg Ser 
                85                  90                  95      


Glu Lys Leu Arg Pro Lys Asn Glu Lys Glu Ile Lys Asn Leu Lys Lys 
            100                 105                 110         


Gln Leu Tyr Gly Thr Leu Ser Glu Tyr Gly Lys Arg Tyr Thr Ala Pro 
        115                 120                 125             


Glu Gly Ala Met Thr Leu Asn Asp Ala Leu Phe Tyr Leu Val Glu Gly 
    130                 135                 140                 


Asn Pro Leu Lys Gln Ala Met Ala Lys Ala Glu Leu Gly Lys Ile Arg 
145                 150                 155                 160 


Glu Ala Leu Ile Lys Glu Lys Glu Asn Arg Ile Asn Arg Val Arg Tyr 
                165                 170                 175     


Ser Ile Lys Asn Asn Lys Ile Pro Leu Arg Ile Gln Glu Asp Gly Gly 
            180                 185                 190         


Ile Thr Pro Asn Asn Asp Arg Ala Ala Trp Leu Leu Gly Leu Met Lys 
        195                 200                 205             


Pro Ala Asp Pro Ala Lys Gly Ile Thr Asp Cys Tyr Pro Leu Leu Gly 
    210                 215                 220                 


Glu Leu Glu Glu Val Phe Asp Phe Asp Lys Leu Ser Lys Thr Leu His 
225                 230                 235                 240 


Glu Lys Ile Ser Arg Cys Gln Gly Arg Pro Arg Ser Ile Ala Met Ala 
                245                 250                 255     


Val Asp Glu Ala Leu Lys Gln Tyr Leu Arg Glu Leu Trp Glu Lys Ser 
            260                 265                 270         


Pro Ser Arg Gln Gln Asp Leu Lys Tyr Tyr Phe Gln Ala Val Gln Glu 
        275                 280                 285             


Tyr Phe Lys Asp Asn Phe Pro Ile Arg Thr Lys Arg Met Gly Ala Arg 
    290                 295                 300                 


Leu Arg Gln Glu Leu Leu Lys Asp Lys Thr Ser Leu Ser Arg Leu Leu 
305                 310                 315                 320 


Glu Pro Lys His Met Ala Asn Ala Val Arg Arg Arg Leu Ile Asn Gln 
                325                 330                 335     


Ser Thr Gln Met His Ile Leu Tyr Gly Lys Leu Tyr Ala Tyr Cys Cys 
            340                 345                 350         


Gly Glu Asp Gly Arg Leu Leu Val Asn Ser Glu Thr Leu Gln Arg Ile 
        355                 360                 365             


Gln Val His Glu Ala Val Lys Lys Gln Ala Met Thr Ala Val Leu Trp 
    370                 375                 380                 


Ser Ile Ser Arg Leu Arg Tyr Phe Tyr Gln Phe Glu Asp Gly Asp Ile 
385                 390                 395                 400 


Leu Ser Asn Lys Asn Pro Ile Lys Asp Phe Arg Asp Lys Phe Leu Arg 
                405                 410                 415     


Asp Thr Asn Lys Tyr Thr His Glu Asp Val Glu Ala Cys Lys Glu Lys 
            420                 425                 430         


Leu Gln Asp Phe Phe Pro Leu Lys Glu Leu Gln Glu Lys Ile Lys Glu 
        435                 440                 445             


Asp Ala Lys Gly Leu Gln Glu Thr Asp Asn Lys Gln Ala Asp Thr Thr 
    450                 455                 460                 


Asp Phe Lys Ala Ile Gly His Ile Val Arg Asp Asp Arg Lys Leu Cys 
465                 470                 475                 480 


Asn Gln Leu Leu Ala Glu Cys Val Ser Cys Ile Gly Glu Leu Arg His 
                485                 490                 495     


His Ile Phe His Tyr Lys Asn Val Thr Leu Ile Gln Ala Leu Lys Arg 
            500                 505                 510         


Ile Ala Asp Lys Val Lys Pro Glu Asp Leu Ser Val Leu Arg Ala Ile 
        515                 520                 525             


Tyr Leu Leu Asp Arg Arg Asn Leu Lys Lys Ala Phe Ala Lys Arg Ile 
    530                 535                 540                 


Ser Ser Met Asn Leu Pro Leu Tyr Tyr Arg Glu Asp Leu Leu Ser Arg 
545                 550                 555                 560 


Ile Phe Lys Lys Glu Gly Thr Ala Phe Phe Leu Tyr Ser Ala Lys Ile 
                565                 570                 575     


Gln Met Thr Pro Ser Phe Gln Arg Val Tyr Glu Arg Gly Lys Asn Leu 
            580                 585                 590         


Arg Arg Glu Phe Glu Cys Glu Arg Met Lys Ala Glu Ala Ser Asn Gly 
        595                 600                 605             


Gln Asn Gly Gln Asp Gly Asp Arg Leu Lys Trp Phe Arg Gln Leu Ala 
    610                 615                 620                 


Ala Gly Asp Ser Ala Asp Thr His Phe Asn Trp Ala Val Glu Ala Tyr 
625                 630                 635                 640 


Ala Glu Ser Ala Ala Asp Val Glu Asn Asn Val Glu Phe Asp Thr Asp 
                645                 650                 655     


Val Asp Ala Gln Arg Ala Leu Arg Asn Leu Leu Leu Leu Ile Tyr Arg 
            660                 665                 670         


His His Phe Leu Pro Glu Val Gln Lys Asp Glu Thr Leu Val Thr Gly 
        675                 680                 685             


Lys Ile His Lys Val Leu Glu Arg Asn Arg Gln Leu Ser Glu Gly Gln 
    690                 695                 700                 


Gly Pro Asn Gln Gly Lys Ala His Gly Tyr Ser Val Ile Glu Glu Leu 
705                 710                 715                 720 


Tyr His Glu Gly Met Pro Leu Ser Asp Leu Met Lys Gln Leu Gln Arg 
                725                 730                 735     


Arg Ile Ser Glu Thr Glu Arg Glu Ser Arg Glu Leu Ala Gln Glu Lys 
            740                 745                 750         


Thr Asp Tyr Ala Gln Arg Phe Ile Leu Asp Ile Phe Ala Glu Ala Phe 
        755                 760                 765             


Asn Asp Phe Leu Glu Ala His Tyr Gly Glu Glu Tyr Leu Glu Ile Met 
    770                 775                 780                 


Ser Pro Arg Lys Asp Ala Glu Ala Ala Lys Lys Trp Val Lys Glu Ser 
785                 790                 795                 800 


Lys Thr Val Asp Leu Lys Thr Ser Ile Asp Glu Lys Glu Pro Glu Gly 
                805                 810                 815     


His Leu Leu Val Leu Tyr Pro Val Leu Arg Leu Leu Asp Glu Arg Glu 
            820                 825                 830         


Leu Gly Glu Leu Gln Gln Gln Met Ile Arg Tyr Arg Thr Ser Leu Ala 
        835                 840                 845             


Ser Trp Gln Gly Glu Ser Asn Phe Ser Glu Glu Ile Arg Ile Ala Gly 
    850                 855                 860                 


Gln Ile Glu Glu Leu Thr Glu Leu Val Lys Leu Thr Glu Pro Glu Pro 
865                 870                 875                 880 


Gln Phe Ala Glu Glu Val Trp Gly Lys Arg Ala Lys Glu Ala Phe Glu 
                885                 890                 895     


Asp Phe Ile Glu Gly Asn Met Lys Asn Tyr Glu Ala Phe Tyr Leu Gln 
            900                 905                 910         


Ser Asp Asn Asn Thr Pro Val Tyr Arg Arg Asn Met Ser Arg Leu Leu 
        915                 920                 925             


Arg Ser Gly Leu Met Gly Val Tyr Gln Lys Val Leu Ala Ser His Lys 
    930                 935                 940                 


Gln Ala Leu Lys Arg Asp Tyr Leu Leu Trp Ser Glu Lys His Trp Asn 
945                 950                 955                 960 


Val Lys Asp Glu Asn Gly Ala Asp Ile Ser Ser Ala Glu Gln Ala Gln 
                965                 970                 975     


Cys Leu Leu Gln Arg Leu His Arg Lys Tyr Ala Glu Ser Pro Ser Arg 
            980                 985                 990         


Phe Thr Glu Glu Asp Cys Lys Leu  Tyr Glu Lys Val Leu  Arg Arg Leu 
        995                 1000                 1005             


Glu Asp  Tyr Asn Gln Ala Val  Lys Asn Leu Ser Phe  Ser Ser Leu 
    1010                 1015                 1020             


Tyr Glu  Ile Cys Val Leu Asn  Leu Glu Ile Leu Ser  Arg Trp Val 
    1025                 1030                 1035             


Gly Phe  Val Gln Asp Trp Glu  Arg Asp Met Tyr Phe  Leu Leu Leu 
    1040                 1045                 1050             


Ala Trp  Val Arg Gln Gly Lys  Leu Asp Gly Ile Lys  Glu Glu Asp 
    1055                 1060                 1065             


Val Arg  Asp Ile Phe Ser Glu  Gly Asn Ile Ile Arg  Asn Leu Val 
    1070                 1075                 1080             


Asp Thr  Leu Lys Gly Glu Asn  Met Asn Ala Phe Glu  Ser Val Tyr 
    1085                 1090                 1095             


Phe Pro  Glu Asn Lys Gly Ser  Lys Tyr Leu Gly Val  Arg Asn Asp 
    1100                 1105                 1110             


Val Ala  His Leu Asp Leu Met  Arg Lys Asn Gly Trp  Arg Leu Glu 
    1115                 1120                 1125             


Ala Gly  Lys Thr Cys Ser Val  Met Glu Asp Tyr Ile  Asn Arg Leu 
    1130                 1135                 1140             


Arg Phe  Leu Leu Ser Tyr Asp  Gln Lys Arg Met Asn  Ala Val Thr 
    1145                 1150                 1155             


Lys Thr  Leu Gln Gln Ile Phe  Asp Arg His Lys Val  Lys Ile Arg 
    1160                 1165                 1170             


Phe Thr  Val Glu Lys Gly Gly  Met Leu Lys Ile Glu  Asp Val Thr 
    1175                 1180                 1185             


Ala Asp  Lys Ile Ala His Leu  Lys Gly Ser Arg Leu  Ser Gly Ile 
    1190                 1195                 1200             


Glu Ile  Leu Ser His Gly Glu  Arg Phe Ile Asp Thr  Leu Lys Ala 
    1205                 1210                 1215             


Leu Met  Val Tyr Pro Arg Gly  
    1220                 1225 


<210>  655
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  655

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Leu Tyr Gln Ile Val  Ser Ala Phe Asn Phe  Gly Ser Lys 
    1205                 1210                 1215             


Leu Leu  Tyr Ile Ser Glu Asp  Gly Arg Trp Lys Met  Ala Gly Gly 
    1220                 1225                 1230             


Ala Phe  Pro Gly Lys Tyr Gly  Arg Phe Glu Asn Asp  Tyr Asn His 
    1235                 1240                 1245             


Arg Thr  Ser Leu Ser Lys Val  Ile Arg Leu Phe Glu  Asn Glu Ser 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ile Ile Tyr  Trp Arg Asp Tyr Val  Asp His Met 
    1265                 1270                 1275             


Lys Tyr  Tyr Val Asn Gln Asn  Gln Ser Ile Met Glu  Ile Tyr Ser 
    1280                 1285                 1290             


Ala Phe  Tyr Ser Lys Val Leu  Gly Tyr Ser Ala Lys  Leu Arg Lys 
    1295                 1300                 1305             


Ser Val  Val Phe Asn Leu Gln  Ala Ala Leu Glu Lys  His His Ile 
    1310                 1315                 1320             


Asn Pro  Glu Cys Ile Trp Met  Thr Ser Asp Gly Lys  Cys Ala Asp 
    1325                 1330                 1335             


Ile Lys  Leu Met Lys Asn Leu  Glu Ser Gln Lys Phe  Thr Tyr Lys 
    1340                 1345                 1350             


Leu Ala  Lys Arg Glu Gly Glu  Lys Thr Glu Arg Lys  Ile Cys Met 
    1355                 1360                 1365             


Asn Ala  Leu Asn Glu Asn Phe  Leu Lys Thr Ile Arg  Thr Ser Leu 
    1370                 1375                 1380             


Glu Tyr  Lys Lys 
    1385         


<210>  656
<211>  1102
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  656

Met Arg Val Ser Lys Val Lys Val Asp Asn Lys Asn Met Val Leu Met 
1               5                   10                  15      


Arg Arg Thr Thr Gly Asn Gly Ala Leu Val Tyr Glu Gly Glu Thr Ser 
            20                  25                  30          


Asn Arg Thr Ile Glu Ile Leu Pro Lys Gln Lys Ile Gln Ser Phe Ser 
        35                  40                  45              


Leu Ser Ile Glu Asn Lys Thr Leu Ile Lys Arg Asp Ser Leu Lys Gly 
    50                  55                  60                  


Thr Val Gln Lys Asn Lys Tyr Asp Val Ile Arg Ala Ile Ile Lys Tyr 
65                  70                  75                  80  


Asn Arg Phe Pro Asp Arg Ile Ser Ala Glu Glu Val Leu Pro Phe Leu 
                85                  90                  95      


Asn His Lys Phe Gln Asn Glu Ile Lys Tyr Tyr Asn Asp Asn Lys Leu 
            100                 105                 110         


His Ser Phe Leu Leu Thr Ser Leu Ile Val Glu Ala Val Lys Glu Lys 
        115                 120                 125             


Asn Pro Gln Lys Leu Gln Pro Tyr Phe Asp Trp Glu Glu Trp Tyr Ile 
    130                 135                 140                 


Ser Asn Lys Ser Asn Ala Leu Ile Lys Ser Ile Glu Asn Asn Lys Ile 
145                 150                 155                 160 


Asp Ser Glu Lys Lys Asp Ser Lys Arg Lys Lys Thr Leu Gln Thr Trp 
                165                 170                 175     


Ala Ala Glu Tyr Thr Asp Asn Gly Ser Ile Asp Leu Ser Glu Tyr His 
            180                 185                 190         


Asn Ile Tyr Asp Ile Asp Thr Leu Val Arg Ala Leu Ile Lys Ala Asp 
        195                 200                 205             


Lys Gly Glu Leu Lys Glu Asp Gly Thr Pro Lys Asn Ala Asn Ala Phe 
    210                 215                 220                 


His Arg Asn Leu Lys Arg Thr Leu Gln Asp His Gln Lys Thr Val Phe 
225                 230                 235                 240 


Gly Thr Arg Glu Ala Ser Asn Met Thr Asn Arg Glu Asn Asp Gln Leu 
                245                 250                 255     


Ala Val Tyr His Leu Glu Val Val Lys Tyr Leu Glu His Tyr Phe Ser 
            260                 265                 270         


Val Lys Ser Thr Gln Arg Arg Asn Thr Arg Ala Asp Ile Asp Tyr Tyr 
        275                 280                 285             


Leu Lys Ala Glu Thr Ile Lys Asn Ile Ile Thr Lys Gln Leu Leu Asn 
    290                 295                 300                 


Ala Val Arg Asn Tyr Leu Leu Gln Gln Gly Lys Ala Gln His His Lys 
305                 310                 315                 320 


Phe Ala Glu Ile Lys Pro Asp Ser Asn Ser Leu Thr Glu Ile Lys Arg 
                325                 330                 335     


Asn Glu Ala Phe Val Leu Asn Met Ile Asp Ala Cys Gly Phe Ala Ala 
            340                 345                 350         


Asn Asn Ile Arg Asn Ile Val Asp Ala Glu Gln Ile Asn Asp Ile Leu 
        355                 360                 365             


Ser Lys Lys Glu Tyr Val Gln Ser Leu Asp Ser Asn Arg Val Asn Asn 
    370                 375                 380                 


Gln Leu Phe Lys Phe Phe Phe Gly Thr Asp Leu Pro Glu Thr Ala Thr 
385                 390                 395                 400 


Asp Lys Val Lys Thr Leu Trp Ala Met Arg Gly Ala Val Gln Gln Ile 
                405                 410                 415     


Arg Asn Lys Val Val His Tyr Lys Gln Lys Ala Leu Asp Ala Ile Phe 
            420                 425                 430         


Asn Val Thr Asp Phe Glu Tyr Pro Ser Phe Asn Asn Ser Ile Tyr Thr 
        435                 440                 445             


Asp Thr Ile Tyr Lys Asp Cys Leu Glu Thr Glu Leu Gln Lys Leu Pro 
    450                 455                 460                 


Glu Ala Phe Ala Gln Gln Leu Lys Thr Gly Gly Ala Leu Thr Tyr Tyr 
465                 470                 475                 480 


Pro Phe Asp Asp Leu Lys Thr Leu Leu Asn Lys Val Ala Phe Ser Leu 
                485                 490                 495     


Cys Arg Ser Val Val Pro Phe Ala Pro Gly Phe Lys Lys Val Gln Lys 
            500                 505                 510         


Gln Gly Gln Asn Tyr Gln Asn Ala His Lys Glu Asn Phe Tyr Asn Leu 
        515                 520                 525             


Asp Leu Lys Ser Tyr Leu Pro Lys Glu Lys Phe Asp Glu Glu Ala Tyr 
    530                 535                 540                 


Asn Ala Arg Tyr Phe Leu Leu Lys Leu Ile Tyr Asn Asn Leu Phe Leu 
545                 550                 555                 560 


Ser Asp Phe Thr Gly Asn Arg Glu Gln Phe Ser Ala Thr Val Asn Tyr 
                565                 570                 575     


Ile Leu Lys Arg Asn Lys Lys Gln Ala Glu Asn Ser Arg Arg Pro Lys 
            580                 585                 590         


Ala Tyr Ala Phe Glu Ala Val Arg Gln Met Lys Lys Glu Glu Ser Ile 
        595                 600                 605             


Thr Ser Tyr Met Ala Tyr Ala Gln Asn Gln Leu Met Val Glu Lys Asn 
    610                 615                 620                 


Lys Lys Glu Asp Asp Lys Pro Glu Asp Ile Arg Ile Asn Phe Glu Lys 
625                 630                 635                 640 


Phe Val Leu Gln Val Phe Ile Lys Gly Phe Asp Asp Phe Leu Leu Asn 
                645                 650                 655     


Glu Lys Phe Lys Phe Ile Ala Thr Pro Cys Phe Gln Leu Ser Lys Glu 
            660                 665                 670         


Asn Thr Lys Gln Gln Gln Ala Asp Val Leu Asn Gln Phe Glu Gln Arg 
        675                 680                 685             


Ile Ile Lys Glu Cys Arg Phe Gln Ser His Thr Ile Lys Ala Glu Glu 
    690                 695                 700                 


Ala Lys His Val Ala Phe Phe Thr Phe Cys Lys Leu Leu Asp Ala Thr 
705                 710                 715                 720 


His Leu Ser Asn Leu Arg Asn Glu Leu Ile Lys Phe Lys Gln Ser Ser 
                725                 730                 735     


Lys Gln Phe Glu Leu Cys His Val Leu Glu Ile Ile Glu Leu Ser Leu 
            740                 745                 750         


Leu Asn Ala Asp Val Val Pro Ala Asp Tyr Arg Glu Leu Tyr Ala Asn 
        755                 760                 765             


Lys Val Thr Cys Leu Asn Arg Val Arg Pro Phe Ile Ala Asp Gly Val 
    770                 775                 780                 


Asp Ile Thr Lys Trp Ser Gly Leu Phe Ile Gln Thr Asp Asn Glu Thr 
785                 790                 795                 800 


Pro Val Ile His Ala Asn Val Glu Leu Thr Val Lys Tyr Gly Thr Thr 
                805                 810                 815     


Lys Leu Leu Glu Gln Leu Ile Ala Lys Gly Ala Ser Phe Lys Leu Ser 
            820                 825                 830         


Glu Ser Asp Phe Asn Leu Trp Asn Ser Ala Lys Asp Thr Ile Lys Glu 
        835                 840                 845             


Val Ile Asn Lys Arg Leu Ser Leu His Lys Gln Trp Glu Asp Ala Ile 
    850                 855                 860                 


Arg Lys Asp Lys Glu Glu Lys Asn Lys Arg Val Lys Thr Arg Ser Asn 
865                 870                 875                 880 


Phe Ala Gln Gln Phe Ile Asn Lys Glu Arg Asp Ser Tyr Phe Asp Leu 
                885                 890                 895     


Cys Asp Tyr Ile Asp Ala Tyr Asn Trp Tyr Asp Ser Lys Leu His Phe 
            900                 905                 910         


Val Asn Leu Ile Arg Leu His His Leu Thr Ile Asp Ile Leu Gly Arg 
        915                 920                 925             


Met Val Gly Phe Val Ala Ile Trp Glu Arg Asp Phe Gln Tyr Met Thr 
    930                 935                 940                 


Glu Ser Ile Ser Pro Met Asn Ser Ser Lys Glu Leu Asp Phe Thr Lys 
945                 950                 955                 960 


Gly Phe Pro Leu Leu Lys Gly Ile Gln Leu Asp Tyr Tyr Lys Arg Ile 
                965                 970                 975     


Phe Leu Ser Gly Asn Tyr Arg Asp Ile Arg Asn Tyr Ile Ala His Phe 
            980                 985                 990         


Asn Tyr Leu Thr Asp Ser Lys Phe  Ser Met Ile Asp Leu  Ile Asn Glu 
        995                 1000                 1005             


Leu Arg  Glu Leu Leu Ser Tyr  Asp Arg Lys Leu Lys  Asn Ala Val 
    1010                 1015                 1020             


Asn Lys  Ala Phe Ile Asp Leu  Phe Asp Lys Gln Gly  Met Val Leu 
    1025                 1030                 1035             


Lys Leu  Lys Leu Asn Asp Ala  His Arg Phe Glu Ile  Glu Ser Val 
    1040                 1045                 1050             


Glu Pro  Lys Leu Leu Tyr His  Leu Gly Thr Thr Pro  Ala Arg Asp 
    1055                 1060                 1065             


Pro Ile  Ser Thr Tyr Gln Val  Lys Pro Gln Tyr Cys  Asp Met Cys 
    1070                 1075                 1080             


Lys Ala  Leu Leu Glu Ile Lys  Asn Ser Ser Arg Leu  Asn Asn Val 
    1085                 1090                 1095             


Ile Ile  Ser Leu 
    1100         


<210>  657
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  657

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Pro Gly Thr Asp Thr 
            20                  25                  30          


Ile Gly Leu Lys Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Asp Lys Pro Lys Lys 
    50                  55                  60                  


Trp Lys Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Glu Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Ser Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Met Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Tyr Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ser Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Lys Asp Arg Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Lys Glu Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Gln Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Phe 
            660                 665                 670         


Ile Arg Lys Asn Phe Pro Glu Asp Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Asp Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Asp Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asn  Ser Glu Lys Lys Glu  Ala Tyr Gln Lys Ile  Glu Val Asn 
    1100                 1105                 1110             


Gly Asp  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Val  Tyr Ala Pro Asp Glu  Lys Gly Asp 
    1130                 1135                 1140             


Ile Leu  Lys Glu Gln Cys Thr  Lys Gly Gly Ala Gly  Gly Lys Ile 
    1145                 1150                 1155             


Ser Ala  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Lys Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Lys Gln 
    1250                 1255                 1260             


Thr Thr  Ser Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Ser Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Lys  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Val Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Gly Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Pro Asn 
    1370                 1375                 1380         


<210>  658
<211>  1143
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  658

Met Arg Val Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Val Tyr Ser Gly 
            20                  25                  30          


Gln Pro Val Ser Asn Glu Thr Cys Asn Ile Leu Pro Glu Lys Lys Arg 
        35                  40                  45              


Gln Ser Phe Asp Leu Ser Ile Glu Asn Lys Thr Leu Lys Arg Arg Asp 
    50                  55                  60                  


Asp Val Asp Lys Thr Lys Lys Gly Lys Tyr Asp Ile Val Arg Lys Ile 
65                  70                  75                  80  


Ile Lys Tyr Gly Glu Leu Pro Gln Ser Ile Asn Asp Val Asp Ile Leu 
                85                  90                  95      


Glu Phe Leu Asn His Lys Phe Gln Lys Pro Val Lys Tyr Trp Lys Asn 
            100                 105                 110         


Gly Lys Glu Glu Ser Phe Asn Leu Thr Leu Leu Ile Val Glu Ala Val 
        115                 120                 125             


Lys Thr Gln Asp Arg Gln Lys Leu Gln Pro Tyr Tyr Asp Trp Lys Thr 
    130                 135                 140                 


Trp Tyr Ile Gln Thr Lys Ser Asp Leu Leu Lys Lys Ser Ile Glu Asn 
145                 150                 155                 160 


Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg Lys Lys Ala Leu 
                165                 170                 175     


Leu Ala Trp Glu Thr Glu Phe Thr Thr Ser Gly Lys Ile Asp Leu Thr 
            180                 185                 190         


His Tyr His Lys Val Tyr Met Thr Asp Val Leu Cys Thr Ala Leu Gln 
        195                 200                 205             


Lys Val Glu Pro Ser Thr Asp Lys Lys Gly Lys Ile Asn Thr Asn Ala 
    210                 215                 220                 


Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Thr His Gln Pro Ala Ile 
225                 230                 235                 240 


Phe Gly Thr Arg Gln Ala Pro Asn Asn Val Asn Arg Ala Asp Asp Arg 
                245                 250                 255     


Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu Glu His Tyr Phe 
            260                 265                 270         


Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Ala Asp Asp Ile Glu His 
        275                 280                 285             


Tyr Leu Lys Thr Gln Thr Leu Lys Thr Thr Ile Glu Lys Gln Leu Val 
    290                 295                 300                 


Asn Ala Ile Arg Ala Asn Ile Ile Gln Gln Gly Lys Thr Asn His His 
305                 310                 315                 320 


Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile Arg Ile Lys Thr 
                325                 330                 335     


Asn Glu Ala Phe Val Leu Asn Leu Thr Gly Thr Cys Ala Phe Ala Ala 
            340                 345                 350         


Asn Asn Ile Arg Asn Met Val Asp Asn Glu Gln Thr Asn Asp Ile Leu 
        355                 360                 365             


Gly Lys Gly Asp Phe Ile Lys Ser Leu Leu Lys Asp Asn Thr Asn Gly 
    370                 375                 380                 


Gln Leu Tyr Ser Phe Phe Phe Gly Glu Ser Leu Ser Thr Asn Lys Ala 
385                 390                 395                 400 


Glu Lys Glu Thr Gln Leu Trp Gly Ile Arg Gly Ala Val Gln Gln Ile 
                405                 410                 415     


Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu Lys Thr Val Phe 
            420                 425                 430         


Asn Ile Ser Asn Phe Glu Asn Pro Thr Ile Thr Asp Pro Lys Gln Gln 
        435                 440                 445             


Thr Asn Tyr Ala Asp Thr Ile Tyr Lys Ala Leu Phe Ile Lys Glu Leu 
    450                 455                 460                 


Glu Lys Ile Pro Asn Ala Phe Ala Gln Gln Leu Lys Thr Gly Gly Ala 
465                 470                 475                 480 


Leu Ser Tyr Tyr Thr Ile Glu Asn Leu Lys Ser Leu Leu Thr Thr Phe 
                485                 490                 495     


Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala Pro Gly Phe Lys 
            500                 505                 510         


Lys Val Phe Asn Gly Gly Ile Asn Tyr Gln Asn Ala Lys Gln Asp Glu 
        515                 520                 525             


Ser Phe Tyr Glu Leu Met Leu Glu Arg Tyr Leu Arg Lys Glu Asn Phe 
    530                 535                 540                 


Ala Glu Glu Ala Tyr Asn Ala Arg Tyr Phe Leu Leu Lys Leu Ile Tyr 
545                 550                 555                 560 


Asn Asn Leu Phe Leu Pro Gly Phe Thr Arg Asp Arg Lys Ala Phe Ala 
                565                 570                 575     


Asp Ser Val Gly Phe Val Gln Met Gln Asn Lys Lys Gln Ala Glu Lys 
            580                 585                 590         


Val Asn Pro Lys Lys Arg Glu Ala Tyr Ala Phe Glu Ala Val Arg Pro 
        595                 600                 605             


Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala Tyr Val Gln Ser 
    610                 615                 620                 


Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys Ala Thr Asp Glu 
625                 630                 635                 640 


Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val Phe Val Lys Gly 
                645                 650                 655     


Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe Val Gln Val Pro 
            660                 665                 670         


Gln Pro Gln Leu Thr Ala Thr Ala Ser Asn Gln Gln Lys Ala Asp Lys 
        675                 680                 685             


Leu Asn Gln Leu Glu Ala Ser Ile Thr Ala Asp Cys Lys Leu Thr Pro 
    690                 695                 700                 


Gln Tyr Ala Lys Ala Asp Asn Ala Thr His Ile Ala Phe Tyr Val Phe 
705                 710                 715                 720 


Cys Lys Leu Leu Asp Ala Gly His Leu Ser Asn Leu Arg Asn Glu Leu 
                725                 730                 735     


Ile Lys Phe Arg Glu Ser Val Asn Glu Phe Lys Phe His His Leu Leu 
            740                 745                 750         


Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val Val Pro Thr Asp 
        755                 760                 765             


Tyr Arg Asp Leu Tyr Ser Ser Glu Ala Asp Cys Leu Ala Arg Leu Arg 
    770                 775                 780                 


Pro Phe Ile Glu Gln Gly Ala Asp Ile Thr Asn Trp Ser Asp Leu Phe 
785                 790                 795                 800 


Val Gln Ser Asp Lys His Ser Pro Val Ile His Ala Asn Ile Glu Leu 
                805                 810                 815     


Ser Val Lys Tyr Gly Thr Thr Lys Leu Leu Glu Gln Ile Ile Asn Lys 
            820                 825                 830         


Asp Pro Gln Phe Lys Thr Thr Glu Ala Asn Phe Thr Ala Trp Asn Thr 
        835                 840                 845             


Ala Gln Lys Ser Ile Glu Gln Leu Ile Lys Gln Arg Glu Asp His His 
    850                 855                 860                 


Glu Gln Trp Val Lys Ala Lys Asn Ala Asp Asp Lys Glu Lys Gln Glu 
865                 870                 875                 880 


Arg Lys Arg Glu Lys Ser Asn Phe Ala Gln Lys Phe Ile Glu Lys His 
                885                 890                 895     


Gly Asp Asp Tyr Leu Asp Ile Cys Asp Tyr Ile Asn Thr Tyr Asn Trp 
            900                 905                 910         


Leu Asp Asn Lys Met His Phe Val His Leu Asn Arg Leu His Gly Leu 
        915                 920                 925             


Thr Ile Glu Leu Leu Gly Arg Met Ala Gly Phe Val Ala Leu Phe Asp 
    930                 935                 940                 


Arg Asp Phe Gln Met Leu Asp Ala Lys Arg Ile Ser Asp Leu Tyr Gln 
945                 950                 955                 960 


Leu Lys Ser Phe Ile Ser Phe Arg Glu Ile Thr Ser Glu Leu Asp Lys 
                965                 970                 975     


Asn Asn Asp Ile Thr Glu Ile Asn Leu Ile Lys Asp Lys Glu Ile Ile 
            980                 985                 990         


Lys Arg Asp Gly Thr Pro Ile Thr  Glu Ala Asp Arg Asn  Ser Leu Lys 
        995                 1000                 1005             


Ser Cys  Ile Gln Ser Lys Arg  Glu Tyr Tyr Gln Lys  Thr Tyr Phe 
    1010                 1015                 1020             


Lys Glu  His Thr Asn Pro Phe  Thr Asp Arg Asn Tyr  Ile Ala His 
    1025                 1030                 1035             


Phe Asn  Tyr Leu Ser Thr Asn  Thr Gly Asn His Ser  Leu Ile Lys 
    1040                 1045                 1050             


Leu Ile  Asn Lys Leu Arg Asp  Leu Leu His Tyr Asp  Arg Lys Leu 
    1055                 1060                 1065             


Lys Asn  Ala Val Ser Lys Ala  Phe Ile Asp Leu Phe  Asp Lys His 
    1070                 1075                 1080             


Gly Met  Ile Leu Lys Leu Lys  Leu Asn Thr Asp His  Gln Leu Glu 
    1085                 1090                 1095             


Val Glu  Ser Leu Glu Pro Lys  Lys Ile Tyr His Leu  Gly Ser Ser 
    1100                 1105                 1110             


Ala Lys  Asp Lys Pro Glu Tyr  Gln Tyr Cys Thr Asn  Gln Val Met 
    1115                 1120                 1125             


Met Ala  Tyr Cys Asn Met Cys  Arg Ser Leu Leu Glu  Met Lys Lys 
    1130                 1135                 1140             


<210>  659
<211>  1403
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  659

Met Gly Asn Leu Phe Gly Tyr Lys Arg Trp Tyr Glu Val Ser Asp Arg 
1               5                   10                  15      


Gly Asp Asn Lys Ile Lys Arg Lys Val Lys Ile Lys Arg Asn Tyr Asp 
            20                  25                  30          


Gly Asn Lys Tyr Ile Leu Asn Ile Asn Glu Asn Asn Asn Lys Glu Lys 
        35                  40                  45              


Ile Glu Asn Asn Glu Phe Ile Arg Glu Phe Val Asn Tyr Lys Lys Asn 
    50                  55                  60                  


Asp Asn Val Leu Arg Glu Phe Lys Arg Lys Phe His Ala Gly Asn Ile 
65                  70                  75                  80  


Leu Phe Lys Leu Lys Gly Asn Lys Arg Ser Ile Gly Asp Ser Asn Asp 
                85                  90                  95      


Phe Leu Lys Thr Glu Glu Ile Ile Leu Asp Lys Glu Val Tyr Gly Gln 
            100                 105                 110         


Ser Glu Lys Leu Arg Asn Glu Lys Gly Ile Thr Lys Gln Asp Ile Leu 
        115                 120                 125             


Lys Glu Ile Ile Asp Lys Gly Ile Asp Lys Ser Asn Asp Lys Ile Leu 
    130                 135                 140                 


Val Lys Thr Lys Leu Gly Lys Glu Ile Thr Ile Asn Phe Thr Asp Glu 
145                 150                 155                 160 


Asp Lys Lys Asn Lys Lys Glu Tyr Gln Ile Thr Leu Lys Ile Ile Pro 
                165                 170                 175     


Glu Asn Glu Leu Lys Ile Lys Arg Glu Val Tyr Asn Val Phe Lys Ile 
            180                 185                 190         


Ile Asn Met Asn Leu Tyr Gln Ile Ile Lys Gly Ile Ile Glu Asn Lys 
        195                 200                 205             


Glu Ile Phe Lys Asn Arg Tyr Tyr Asp Glu Ile Leu Lys Glu Lys Leu 
    210                 215                 220                 


Ser Lys Asn Asn Gln Ile Ile Asn Thr Leu Thr Asn Leu Asn Lys Ile 
225                 230                 235                 240 


Arg Lys Glu Ile Arg Asp Asn Arg Asp Asn Ile Ile Gly Phe Val Lys 
                245                 250                 255     


Phe Tyr Leu Asn Val Ser Gly Asp Lys Lys Lys Ser Glu Asn Lys Lys 
            260                 265                 270         


Met Phe Val Glu Lys Ile Leu Asn Ile Asn Val Asp Leu Thr Val Glu 
        275                 280                 285             


Asp Ile Val Asp Phe Ile Val Lys Glu Leu Lys Phe Trp Asn Ile Thr 
    290                 295                 300                 


Lys Arg Ile Glu Lys Val Lys Glu Phe Asn Asn Lys Phe Leu Glu Asn 
305                 310                 315                 320 


Lys Arg Asn Arg Thr Tyr Ile Lys Ser Tyr Val Leu Leu Asp Lys His 
                325                 330                 335     


Glu Lys Phe Lys Ile Glu Arg Glu Asn Lys Lys Asp Lys Ile Val Lys 
            340                 345                 350         


Phe Phe Val Glu Asn Ile Lys Asn Asn Ser Ile Lys Glu Lys Ile Glu 
        355                 360                 365             


Lys Ile Leu Ala Glu Phe Lys Ile Asp Glu Leu Thr Lys Lys Leu Glu 
    370                 375                 380                 


Lys Gly Asn Cys Asp Thr Glu Ile Phe Gly Ile Phe Lys Lys His Tyr 
385                 390                 395                 400 


Lys Val Asn Phe Asp Ser Lys Lys Phe Ser Asn Lys Ser Asp Glu Glu 
                405                 410                 415     


Lys Glu Leu Tyr Lys Ile Ile Tyr Arg Tyr Leu Lys Gly Arg Ile Glu 
            420                 425                 430         


Lys Ile Leu Ile Asn Glu Glu Lys Val Arg Leu Lys Lys Met Glu Lys 
        435                 440                 445             


Ile Glu Ile Glu Lys Ile Leu Asn Glu Ser Ile Leu Ser Glu Lys Ile 
    450                 455                 460                 


Leu Lys Arg Ile Lys Gln Tyr Thr Leu Glu His Ile Met Tyr Leu Gly 
465                 470                 475                 480 


Lys Leu Val His Asn Lys Ile Asn Met Ala Thr Val Asn Thr Asn Asp 
                485                 490                 495     


Phe Phe Arg Leu His Ala Lys Glu Glu Leu Asp Leu Glu Leu Ile Thr 
            500                 505                 510         


Phe Phe Ala Ser Thr Asn Met Glu Leu Asn Lys Ile Phe Ser Arg Glu 
        515                 520                 525             


Asn Ile Asn Asn Asp Glu Asn Ile Asp Phe Phe Gly Gly Asp Arg Glu 
    530                 535                 540                 


Lys Asn Tyr Val Ile Asp Lys Lys Asn Leu Asn Ser Lys Ile Lys Ile 
545                 550                 555                 560 


Ile Arg Asp Leu Asp Phe Ile Asp Asn Lys Asn Asn Ile Thr Asn Asp 
                565                 570                 575     


Phe Ile Asn Lys Phe Thr Lys Ile Gly Thr Asn Glu Arg Asn Arg Ile 
            580                 585                 590         


Leu His Ala Ser Gly Lys Lys Arg Asp Ser Gln Gly Thr Gln Asp Asp 
        595                 600                 605             


Tyr Asn Lys Val Ile Asn Ile Ile Gln Asn Leu Lys Ile Ser Asp Glu 
    610                 615                 620                 


Glu Val Ser Lys Ala Leu Asn Leu Asp Val Val Phe Lys Asp Lys Lys 
625                 630                 635                 640 


Asn Ile Ile Thr Glu Ile Asn Asp Ile Lys Ile Ser Glu Glu Asn Ser 
                645                 650                 655     


Asn Asp Ile Lys Tyr Leu Pro Ser Phe Ser Lys Val Leu Pro Glu Ile 
            660                 665                 670         


Leu Asn Leu Tyr Arg Asn Asn Pro Lys Asn Lys Pro Phe Asp Thr Ile 
        675                 680                 685             


Glu Thr Glu Lys Ile Val Leu Asn Ala Leu Ile Tyr Val Asn Lys Glu 
    690                 695                 700                 


Leu Tyr Lys Lys Leu Ile Leu Glu Asp Asp Leu Lys Lys Asn Arg Ser 
705                 710                 715                 720 


Glu Asn Ile Phe Leu Gln Glu Leu Lys Lys Thr Leu Gly Asn Ile Asp 
                725                 730                 735     


Glu Thr Asp Glu Asn Ile Ile Glu Asn Tyr Tyr Lys Asn Ala Gln Ile 
            740                 745                 750         


Ser Ala Ser Lys Gly Asn Asn Lys Val Ile Lys Lys Tyr Gln Lys Lys 
        755                 760                 765             


Val Ile Glu Cys Tyr Ile Gly Tyr Leu Arg Lys Asn Tyr Glu Lys Leu 
    770                 775                 780                 


Phe Asp Phe Ser Asp Phe Lys Met Asn Ile Gln Glu Ile Lys Lys Gln 
785                 790                 795                 800 


Ile Lys Asp Ile Asn Asp Asn Lys Thr Tyr Glu Arg Ile Thr Ile Lys 
                805                 810                 815     


Thr Ser Asp Lys Ser Ile Val Ile Asn Asp Asp Phe Glu Tyr Ile Ile 
            820                 825                 830         


Ser Ile Phe Ala Leu Leu Asn Ser Asn Thr Ile Ile Asn Lys Ile Arg 
        835                 840                 845             


Asn Arg Phe Phe Ala Thr Ser Val Trp Leu Glu Lys Gln Asn Ser Thr 
    850                 855                 860                 


Lys Glu Tyr Asp Tyr Glu Asn Ile Ile Ser Ile Leu Asp Glu Ile Met 
865                 870                 875                 880 


Gln Leu Asn Thr Leu Arg Asn Glu Cys Ile Thr Glu Asn Trp Asn Leu 
                885                 890                 895     


Asn Leu Glu Glu Phe Ile Gln Lys Met Lys Asp Ile Glu Lys Glu Phe 
            900                 905                 910         


Glu Asp Phe Lys Ile Gln Thr Lys Lys Asp Ile Phe Asn Ser Asn Tyr 
        915                 920                 925             


Glu Gly Ile Lys Asn Asn Val Leu Asn Lys Phe Ile Gly Phe Ser Asp 
    930                 935                 940                 


Val Gln Lys Ile Leu Glu Glu Lys Leu Asn Lys Leu Ile Glu Phe Glu 
945                 950                 955                 960 


Asn Asp Asn Glu Ile Lys Lys Ser Val Asn Leu Asp Ser Leu Asp Ser 
                965                 970                 975     


Asp Glu Arg Arg Lys Leu Met Pro Asn Ile Asn Pro Lys Lys Gly Gly 
            980                 985                 990         


Ile Asp Leu Ile Lys Glu Ile Asp  Lys Leu Ile Met Ile  Glu Lys Asn 
        995                 1000                 1005             


Asn Ile  Glu Lys Asn Ile Leu  Leu Lys Ile Ile Phe  Asn Ser Asp 
    1010                 1015                 1020             


Phe Leu  Glu Lys Tyr Lys Glu  Glu Ile Asp Asn Leu  Val Glu Cys 
    1025                 1030                 1035             


Thr Glu  Ser Lys Asn Glu Asn  Lys Phe Glu Lys Ile  Tyr Tyr Pro 
    1040                 1045                 1050             


Glu Glu  His Lys Asn Glu Leu  Tyr Ile Tyr Lys Lys  Asn Leu Phe 
    1055                 1060                 1065             


Leu Asn  Ile Gly Asn Pro Asn  Phe Asp Lys Ile Tyr  Glu Leu Ile 
    1070                 1075                 1080             


Ser Lys  Asp Ile Lys Asn Ala  Asn Thr Glu Ile Leu  Phe Asn Asp 
    1085                 1090                 1095             


Asp Ile  Arg Asn Asn Lys Ile  Ala Glu Ile Asp Val  Ile Leu Lys 
    1100                 1105                 1110             


Lys Leu  Asn Asp Lys Leu Ser  Gly Tyr Ser Lys Glu  Tyr Lys Glu 
    1115                 1120                 1125             


Lys Tyr  Ile Lys Lys Leu Lys  Glu Asn Gln Glu Asn  Asn Asp Phe 
    1130                 1135                 1140             


Phe Ser  Lys Asn Ile Gln Asn  Glu Asn Tyr Ser Ser  Phe Arg Glu 
    1145                 1150                 1155             


Phe Lys  Lys Asp Tyr Asn Lys  Val Ser Glu Tyr Lys  Lys Ile Arg 
    1160                 1165                 1170             


Asp Leu  Val Glu Phe Asn Tyr  Leu Asn Lys Ile Glu  Ser Tyr Leu 
    1175                 1180                 1185             


Ile Asp  Ile Asn Trp Lys Leu  Ala Ile Gln Met Ala  Arg Phe Glu 
    1190                 1195                 1200             


Arg Asp  Met His Tyr Ile Val  Asn Gly Leu Arg Glu  Leu Gly Ile 
    1205                 1210                 1215             


Ile Lys  Leu Asn Gly Tyr Asn  Thr Gly Ile Ser Arg  Ala Tyr Pro 
    1220                 1225                 1230             


Lys Arg  Asn Gly Thr Gly Asp  Phe Tyr Ile Thr Thr  Ala Tyr Tyr 
    1235                 1240                 1245             


Lys Phe  Phe Asp Glu Glu Ser  Tyr Lys Lys Phe Glu  Lys Ile Cys 
    1250                 1255                 1260             


Tyr Gly  Phe Gly Ile Asp Leu  Ser Glu Asn Ser Glu  Ile Asn Lys 
    1265                 1270                 1275             


Pro Glu  Asn Glu Ser Ile Arg  Asn Tyr Ile Ser His  Phe Tyr Ile 
    1280                 1285                 1290             


Val Arg  Asn Pro Phe Val Asp  Tyr Ser Ile Ala Glu  Gln Ile Asp 
    1295                 1300                 1305             


Arg Val  Ser Asn Leu Leu Ser  Tyr Ser Thr Arg Tyr  Asn Asn Ser 
    1310                 1315                 1320             


Thr Tyr  Ala Ser Val Phe Glu  Val Phe Lys Lys Asp  Val Asp Leu 
    1325                 1330                 1335             


Asp Tyr  Asp Lys Leu Lys Thr  Lys Phe Lys Leu Phe  Asp Asp Glu 
    1340                 1345                 1350             


Lys Asn  Asp Asp Ile Lys Ile  Leu Lys Ile Glu Asp  Leu Ile Glu 
    1355                 1360                 1365             


Ser Lys  Lys Val Ser Val Leu  Glu Leu Glu Ser Tyr  Asn Ser Asn 
    1370                 1375                 1380             


Tyr Val  Lys Asn Leu Ile Ile  Lys Leu Leu Thr Lys  Val Glu Asn 
    1385                 1390                 1395             


Thr Asn  Asn Thr Leu 
    1400             


<210>  660
<211>  911
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  660

Leu Lys Trp Arg Lys Asn Met Lys Leu Ser Lys Val Thr Tyr Arg Val 
1               5                   10                  15      


Lys Asp Lys Asn Ala Lys Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala 
            20                  25                  30          


Val Ala Asn Asn Ser Glu Asn Ala Gly Gly Val Leu Tyr His Val Pro 
        35                  40                  45              


Gly Val Asp Leu Ile Asp Leu Arg Glu Gln Met Leu Asp Arg Asp Arg 
    50                  55                  60                  


Ser Val Arg Leu Leu Tyr Asn Ile Phe Asn His Ile Gln Thr Gly Thr 
65                  70                  75                  80  


Lys Pro Lys Lys Trp Gly Asn Asp Glu Thr Leu Ser Val Asp Glu Asn 
                85                  90                  95      


Glu Arg Lys Ala Lys Glu Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp 
            100                 105                 110         


Arg Glu Ala Cys Ser Glu Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn 
        115                 120                 125             


Ser Val Leu Phe Tyr Ser Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg 
    130                 135                 140                 


Met Asn Asp Asn Glu Ala Ile Ile Val Lys Met Gln Tyr Glu Asn Arg 
145                 150                 155                 160 


Leu Ser His Phe Thr Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr 
                165                 170                 175     


Leu Arg Asn Ser Leu Val Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp 
            180                 185                 190         


Ser Val Asn Ala Met Val Val Phe Ile Asn Asn Ile Gly Asn Gly Asn 
        195                 200                 205             


Ile Ser Asp Lys Asp Lys Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile 
    210                 215                 220                 


Arg Asn Asp Phe Ser Lys Leu Asn Pro Asn Val Gln Ser Ser Gln Gly 
225                 230                 235                 240 


Ala Asn Met Val Arg Ser Val Arg Asn Gln Asn Met Val Val Gln Pro 
                245                 250                 255     


Gln Gly Asp Lys Val Ser Phe Pro Leu Val Ser Asp Glu Gly Lys Asn 
            260                 265                 270         


Thr Val Thr Asn Lys Asn Val Glu Lys Lys Gly Leu Asn Glu Phe Leu 
        275                 280                 285             


Leu Asn Tyr Ala Asn Leu Asp Asp Glu Glu Arg Met Glu Lys Leu Arg 
    290                 295                 300                 


Lys Leu Arg Arg Ile Ile Asp Val Tyr Phe Ser Ser Pro Ser His Tyr 
305                 310                 315                 320 


Gln Lys Asp Met Asp Ile Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys 
                325                 330                 335     


Phe Asp Val Trp Lys Lys His Glu Thr Gly Lys Lys Asn Thr Glu Leu 
            340                 345                 350         


Phe Val Asp Ile Pro Asp Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile 
        355                 360                 365             


Lys Leu Asp Ala Val Leu Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp 
    370                 375                 380                 


Ser Ile Arg Lys Gln Asn Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val 
385                 390                 395                 400 


Val Glu Lys Tyr Asn Ser Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser 
                405                 410                 415     


Ile Asn Gln Tyr Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile 
            420                 425                 430         


Leu Lys Ser Cys Lys Ala Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr 
        435                 440                 445             


Leu Thr Glu Lys Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys 
    450                 455                 460                 


Tyr Ile Ala Leu Gly Lys Val Ile Tyr Asn Phe Thr Val Asp Asp Ile 
465                 470                 475                 480 


Trp Lys Asp Lys Lys Val Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile 
                485                 490                 495     


Lys His Gly Ile Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu 
            500                 505                 510         


Ala Leu Gln Arg Glu Leu Ala Val Asn Val Ala Phe Ala Ala Asn Asn 
        515                 520                 525             


Leu Ala Arg Ala Val Cys Asp Met Thr Asn Leu Lys Asp Lys Glu Ser 
    530                 535                 540                 


Asp Phe Leu Ile Trp Asn Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn 
545                 550                 555                 560 


Lys Asp Asp Met Ala Ser Val Ser Val Val Leu Gln Phe Phe Gly Gly 
                565                 570                 575     


Lys Ser Ser Trp Asp Ile Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn 
            580                 585                 590         


Lys Tyr Asn Tyr Glu Val Cys Phe Ile Asp Asp Leu Arg Lys Ala Val 
        595                 600                 605             


Tyr Ala Ala Arg Asn Glu Ser Phe His Phe Lys Thr Ala Leu Val Asn 
    610                 615                 620                 


Asn Asp Ile Trp Asn Thr Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu 
625                 630                 635                 640 


Thr Glu Ile Cys Leu Asp Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn 
                645                 650                 655     


Leu Pro Val Phe Tyr Ser Asp Asn Asp Leu Lys Lys Met Leu Asp His 
            660                 665                 670         


Leu Tyr Asn Asn Lys Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn 
        675                 680                 685             


Ser Val Met Val Arg Lys Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu 
    690                 695                 700                 


Lys Tyr Gln Lys Pro Gly Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr 
705                 710                 715                 720 


Ser Ala Cys Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu 
                725                 730                 735     


Gln Ser Asp Glu Ala Leu Ala Leu Phe Glu Glu Ser Val Asn Asn Leu 
            740                 745                 750         


Lys Gly Asp Asn Lys Asp Gln Glu Leu Ala Val Lys Asn Phe Arg Asn 
        755                 760                 765             


Asn Tyr Lys Asn Ile Lys Ser Ser Cys Thr Ser Phe Ser Gln Val Cys 
    770                 775                 780                 


Gln Met Tyr Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys 
785                 790                 795                 800 


Val Arg Ser Ser Lys Asp Ser Ile Val Asp Lys Pro Ile Tyr Gln His 
                805                 810                 815     


Tyr Lys Leu Leu Leu Lys Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr 
            820                 825                 830         


Leu Gln His Asn Glu Glu Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys 
        835                 840                 845             


Val Asn Cys Leu Lys Glu Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp 
    850                 855                 860                 


Thr Ser Lys Lys Tyr Val Ser Leu Cys Glu Glu Val Arg Lys Ser Pro 
865                 870                 875                 880 


Glu Leu Gln Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ser Arg Ser 
                885                 890                 895     


Leu Asn Leu Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val 
            900                 905                 910     


<210>  661
<211>  1432
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  661

Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser Val Thr 
1               5                   10                  15      


Glu Asn Lys Asn Glu Glu Gln Leu Ser Arg Gln Ser Leu Leu Tyr Tyr 
            20                  25                  30          


Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp Leu Glu 
        35                  40                  45              


Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr Asn Val 
    50                  55                  60                  


Ile Thr Pro Glu Ile Asp Leu Cys Lys Glu Glu Asn Arg Glu Trp Ile 
65                  70                  75                  80  


Val Glu Asp Leu Thr Lys Asn Phe Asn Ala Val Ile Asn Asn Ala Leu 
                85                  90                  95      


Arg Ser Ile Lys Asn Pro Lys Glu Lys Arg Glu Glu Arg Val Glu Lys 
            100                 105                 110         


Glu Val Ala Phe Ile Leu Asn Leu Asn Lys Asn Ser Ile Lys Ile Lys 
        115                 120                 125             


Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe Ser Ala 
    130                 135                 140                 


Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser Lys Glu 
145                 150                 155                 160 


Glu Ala Tyr Ile Arg Glu Met Ile Ser Asn Leu Val Leu Arg Lys Leu 
                165                 170                 175     


Lys Lys Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Cys Lys Met 
            180                 185                 190         


Gln Met Thr Glu Ile Thr Ile Ser Leu Met Ser Ala Ile Cys Leu Tyr 
        195                 200                 205             


Gly Asn Val Glu Ser Phe Asp Pro Val Ile Leu Lys Ala Phe Phe Glu 
    210                 215                 220                 


Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile Val 
225                 230                 235                 240 


Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys Asp 
                245                 250                 255     


Gly Lys His Leu Leu Ile Pro Ala Asn Ala Asp His Arg Lys Lys Lys 
            260                 265                 270         


Tyr Val Phe Glu Phe Met Arg Lys Tyr Ala Ala Ala Glu Glu Lys Glu 
        275                 280                 285             


Lys Arg Glu Ile Thr Glu His Ile Gln Asn Leu Ile Gly Leu Tyr Leu 
    290                 295                 300                 


Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asn Met 
305                 310                 315                 320 


Thr Glu Ser His Asn Cys Ile Ser Gly Glu Ile Glu Glu Ile Phe Asn 
                325                 330                 335     


Glu Ile Glu Glu Leu Glu Asn Ser Ser Lys Gln Lys Arg Glu Glu Lys 
            340                 345                 350         


Lys Lys Thr Arg Glu Glu Leu Asp Lys Ile Gln Glu Ser Arg Lys Gly 
        355                 360                 365             


Asn Lys Arg Asn Thr Asn Ser Asn Asn Gln Asn Tyr Lys Asn Asn Lys 
    370                 375                 380                 


Thr Asp Ser Asp Lys Lys Glu Asn Gln Ala Asp Ala Asn Glu Asn Lys 
385                 390                 395                 400 


Leu Lys Glu Asn Glu Leu Arg Asp Lys Arg Arg Arg Leu Ser Lys Glu 
                405                 410                 415     


Leu Glu Asn Leu Asp Ser Glu Val Arg Ile Lys Lys Glu Lys Leu Lys 
            420                 425                 430         


Asn Thr Thr Val Lys Glu Met Ala Leu Lys Tyr Arg Ala Ala Val Asn 
        435                 440                 445             


Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile Lys Glu 
    450                 455                 460                 


Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr Ile Asp 
465                 470                 475                 480 


Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp Arg Tyr 
                485                 490                 495     


Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu Trp Thr 
            500                 505                 510         


Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val Tyr His 
        515                 520                 525             


Phe Ala Ile Pro Asp Leu Ser Gly Ala Leu Glu Gly Glu Ser Val Ser 
    530                 535                 540                 


Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly Phe Asp 
545                 550                 555                 560 


Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met Glu Lys 
                565                 570                 575     


Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr Pro Glu 
            580                 585                 590         


Glu Glu Arg Glu Lys Pro Gly His Glu Asp Val Leu Leu Met Lys Thr 
        595                 600                 605             


Leu Ser Glu Ile Glu Glu Ser Gln Thr Glu Glu Glu Arg Gln Lys Lys 
    610                 615                 620                 


His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp Ala Asp 
625                 630                 635                 640 


Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg Lys Lys 
                645                 650                 655     


Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr Lys Glu 
            660                 665                 670         


Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His Tyr Thr 
        675                 680                 685             


Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Glu Leu Thr Glu Tyr 
    690                 695                 700                 


Phe Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg Glu Lys 
705                 710                 715                 720 


Tyr Tyr Thr Asn Asn Val Trp Lys Tyr Tyr Asp Ile Glu Val Ile Asn 
                725                 730                 735     


Asn Ile Met Gly Lys Ile Tyr Cys Gly Arg Lys Tyr Arg Ala Ala Gln 
            740                 745                 750         


Val Pro Ala Phe Asn Asn Ile Ile Ser Arg Pro Ala Leu Pro Gln Leu 
        755                 760                 765             


Met Asp Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met Asn Cys 
    770                 775                 780                 


Pro Asp Arg Asp Val Ile Lys Lys Tyr Trp Ser Ser Leu Phe Phe Val 
785                 790                 795                 800 


Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Glu Lys Pro 
                805                 810                 815     


Glu Asp Asn Ile Lys Glu Arg Phe Phe Arg Ala Met Glu Lys Glu Ser 
            820                 825                 830         


Gly Gln Ala Lys Asp Gly Lys Glu Gln Lys Ala Trp Glu Ser Phe Glu 
        835                 840                 845             


Asn Arg Ile Asp Gln Ile Gly Arg Glu Arg Ser Phe Gly Ala Ile Cys 
    850                 855                 860                 


Gln Gly Leu Met Val Glu Tyr Met Leu Gln Asn Arg Asp Ile Ser Met 
865                 870                 875                 880 


Val Gln Thr Glu Thr Gly Asp Gly Lys Thr Asn Lys Lys Gln Ile Tyr 
                885                 890                 895     


Lys His Tyr Arg Thr Leu Leu Tyr Ile Cys Ile Arg Ser Ala Phe Thr 
            900                 905                 910         


Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro Val Leu Thr 
        915                 920                 925             


Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Gln Thr Asp Gly Leu Lys 
    930                 935                 940                 


His Leu Ser Leu Phe Asp His Leu Lys Glu Thr Phe Asn Asp Ala Glu 
945                 950                 955                 960 


Ser Gly Ser Phe Trp Tyr Met Ala Ala His Phe Ile Asn Gln Lys Tyr 
                965                 970                 975     


Leu Asn His Leu Ile Gly Ser Ile Arg Asn Tyr Leu Gln Phe Thr Glu 
            980                 985                 990         


Asp Ile Glu Asp Arg Ala Leu Ser  Leu Gly Asp Cys Val  Asp Asn Lys 
        995                 1000                 1005             


Arg Glu  Glu Lys Asn Leu Arg  Tyr Arg Asn Thr Leu  Glu Ile Leu 
    1010                 1015                 1020             


Glu Phe  Val Ala Gln Phe Cys  Glu Arg Thr Thr Asn  Val Met Glu 
    1025                 1030                 1035             


Asp Tyr  Phe Glu Ser Asn Gln  Glu Tyr Ala Ala Tyr  Leu Ser Gly 
    1040                 1045                 1050             


Phe Val  Asp Tyr Asn Val Ser  Lys Lys Glu Thr Asp  Ile Glu Lys 
    1055                 1060                 1065             


Ala Leu  Tyr Gly Phe Cys Arg  Gln Lys Phe Lys Val  Asp Gly Lys 
    1070                 1075                 1080             


Glu Tyr  Met Ala Gly Ile Tyr  Tyr Asp Gly Glu Asn  Leu Ile Pro 
    1085                 1090                 1095             


Asn Arg  Asn Ile Ile Arg Ala  Asn Met Tyr Gly Asn  Val Ser Cys 
    1100                 1105                 1110             


Leu Lys  Pro Tyr Met Asp Arg  Ile Thr Leu Lys Glu  Ile Arg Thr 
    1115                 1120                 1125             


Met Tyr  Ala Asp Gln Asn Lys  Leu Asp Thr Val Leu  Lys Glu Gly 
    1130                 1135                 1140             


Val Cys  Arg Thr Glu Glu Glu  Gln Lys Ala Tyr Arg  Glu Tyr Gln 
    1145                 1150                 1155             


Asn Glu  Lys Asn Arg Ile Glu  Leu Phe Asp Leu Cys  Thr Tyr Thr 
    1160                 1165                 1170             


Gln Ile  Leu Asn Asp Ile Gln  Ala Lys Leu Ile Gly  Trp Ser Tyr 
    1175                 1180                 1185             


Met Arg  Glu Arg Asp Leu Met  Tyr Tyr Gln Leu Gly  Tyr Tyr Tyr 
    1190                 1195                 1200             


Thr Lys  Leu Phe Trp Thr Asp  Ser Ile Ser Glu Glu  Asp Ala Arg 
    1205                 1210                 1215             


Arg Arg  Leu Met Gly Glu Leu  Val Asn Val Glu Asp  Gly Val Ile 
    1220                 1225                 1230             


Leu Tyr  Gln Ile Leu Ala Phe  Asn Ser Tyr Asn Leu  Pro Ile Ile 
    1235                 1240                 1245             


Ala Asn  Lys Asn Asn Thr Val  Thr Phe Leu Lys Gly  Glu Gly Ser 
    1250                 1255                 1260             


Ile Gly  Gly Lys Ala Ile Thr  Ala Phe Leu Lys Asn  Tyr Glu Asn 
    1265                 1270                 1275             


Ala Glu  Arg Ile Tyr Glu Glu  Ala Leu Asp Leu Phe  Glu Asn Thr 
    1280                 1285                 1290             


Asp Glu  His Ala Ala Ile Ile  Asn Thr Arg Asn Tyr  Ile Glu His 
    1295                 1300                 1305             


Phe Lys  Tyr Phe Ile Lys Ser  Asp Arg Ser Met Met  Asp Leu Tyr 
    1310                 1315                 1320             


Ser Glu  Val Tyr Asp Arg Phe  Phe Arg His Asp His  Asn Arg Lys 
    1325                 1330                 1335             


Lys Asn  Val Pro Asp Ser Leu  Lys Asn Val Leu Ala  Asp Asn Phe 
    1340                 1345                 1350             


Met Ile  Ala Asp Ile Ser Met  Glu Leu Gly Ser Lys  Lys Val Gly 
    1355                 1360                 1365             


Glu Lys  Lys Lys Gly Phe Arg  Glu His Lys Ala Ala  Arg Ile Glu 
    1370                 1375                 1380             


Phe Thr  Asp Arg Gly Ile Arg  Ser Thr Asp Met Thr  Tyr Thr Val 
    1385                 1390                 1395             


Lys Pro  Asp Pro Lys Asp Ser  Lys Lys Asp Glu Lys  Val Leu Val 
    1400                 1405                 1410             


Pro Ala  Arg Ser Glu Val Phe  Leu Lys Gln Phe Gln  Lys Ile Leu 
    1415                 1420                 1425             


Glu Tyr  Arg Ile 
    1430         


<210>  662
<211>  1167
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  662

Met Lys Val Thr Lys Val Gly Gly Ile Ser His Lys Lys Tyr Thr Ser 
1               5                   10                  15      


Glu Gly Arg Leu Val Lys Ser Glu Ser Glu Glu Asn Arg Thr Asp Glu 
            20                  25                  30          


Arg Leu Ser Ala Leu Leu Asn Met Arg Leu Asp Met Tyr Ile Lys Asn 
        35                  40                  45              


Pro Ser Asn Thr Glu Thr Lys Glu Asn Lys Lys Arg Ile Gly Lys Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Met Val Tyr Leu Lys Asp Asn Thr Leu 
65                  70                  75                  80  


Ser Leu Lys Asn Gly Lys Lys Glu Asn Ile Asp Arg Glu Tyr Ser Glu 
                85                  90                  95      


Thr Asp Ile Ser Glu Tyr Asp Val Arg Asp Ser Lys Asn Phe Ala Val 
            100                 105                 110         


Leu Lys Lys Ile Tyr Leu Asn Glu Asn Val Asn Ser Glu Glu Leu Glu 
        115                 120                 125             


Val Phe Arg Lys Asp Ile Lys Lys Lys Leu Asn Lys Ile Asn Ser Leu 
    130                 135                 140                 


Lys Tyr Ser Phe Glu Lys Asn Lys Ala Asn Tyr Gln Lys Ile Asn Glu 
145                 150                 155                 160 


Asn Asn Ile Glu Lys Val Glu Gly Lys Ser Lys Arg Asn Ile Ile Tyr 
                165                 170                 175     


Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asp Ala Tyr Val Ser Asn Val 
            180                 185                 190         


Lys Glu Ala Phe Asp Lys Leu Tyr Lys Glu Glu Asp Ile Ala Lys Leu 
        195                 200                 205             


Val Leu Lys Ile Glu Asn Leu Thr Lys Leu Glu Lys Ser Lys Ile Arg 
    210                 215                 220                 


Glu Phe Tyr His Glu Ile Ile Gly Arg Lys Asn Asp Lys Glu Asn Phe 
225                 230                 235                 240 


Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Met Lys Glu 
                245                 250                 255     


Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser Gln Val 
            260                 265                 270         


Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Glu Asn Val 
        275                 280                 285             


Lys Tyr Val Phe Cys His Phe Val Glu Ile Glu Met Ser Lys Leu Leu 
    290                 295                 300                 


Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp Lys Val 
305                 310                 315                 320 


Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu Asn Lys 
                325                 330                 335     


Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys Tyr Asn 
            340                 345                 350         


Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile Ala Arg 
        355                 360                 365             


Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val Ser Ser 
    370                 375                 380                 


Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn Lys Asp 
385                 390                 395                 400 


Asp Ile Thr Gly Lys Met Arg Gly Lys Thr Arg Ile Glu Ser Lys Thr 
                405                 410                 415     


Gly Glu Glu Lys Tyr Ile Pro Gly Glu Val Asp Gln Ile Tyr Tyr Glu 
            420                 425                 430         


Asn Lys Gln Asn Glu Val Lys Asn Lys Leu Lys Met Phe Tyr Gly Tyr 
        435                 440                 445             


Asp Phe Asp Met Asp Asn Lys Lys Glu Ile Glu Asp Phe Phe Ala Asn 
    450                 455                 460                 


Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe Asn 
465                 470                 475                 480 


Leu Asp Leu Asp Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Val Pro 
                485                 490                 495     


Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys Lys 
            500                 505                 510         


Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe Arg 
        515                 520                 525             


Tyr Leu Glu Lys Asp Arg Ile Leu Asp Tyr Leu Arg Ser Thr Arg Phe 
    530                 535                 540                 


Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys Leu 
545                 550                 555                 560 


Tyr Asp Arg Ile Asp Asp Leu Lys Ile Ser Leu Asn Ile Tyr Trp Lys 
                565                 570                 575     


Thr Pro Lys Thr Asn Asp Asp Ile Lys Thr Lys Glu Ile Thr Asp Ala 
            580                 585                 590         


Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Lys Phe Leu Asp Tyr 
        595                 600                 605             


Phe Met Ser Arg Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Val Ile 
    610                 615                 620                 


Lys Leu Asn Lys Asn Asn Lys Lys Asn Val Lys Thr Gly Phe Tyr Lys 
625                 630                 635                 640 


Leu Gln Lys Phe Glu Asn Leu Glu Ala Arg Ser Pro Lys Glu Tyr Leu 
                645                 650                 655     


Ala Lys Val Gln Ser Leu Tyr Ile Ile Asn Val Ala Asn Gln Asp Glu 
            660                 665                 670         


Glu Glu Lys Asn Thr Tyr Ile Asp Phe Ile Gln Lys Val Phe Leu Lys 
        675                 680                 685             


Gly Phe Ile Thr Tyr Leu Ala Asn Asn Arg Arg Leu Ser Leu Met Tyr 
    690                 695                 700                 


Ile Gly Ser Asp Glu Glu Val Asn Asn Ser Leu Ala Glu Lys Lys Gln 
705                 710                 715                 720 


Glu Phe Asp Lys Phe Trp Arg Lys Tyr Glu Glu Asn Asn Asp Ile Glu 
                725                 730                 735     


Ile Pro Asp Glu Ile Asn Glu Phe Leu Lys Glu Ile Lys Leu Gly Lys 
            740                 745                 750         


Ile Leu Lys Asn Ser Ala Lys Leu Asn Ile Phe Tyr Leu Ile Leu Lys 
        755                 760                 765             


Leu Leu Asn Asn Lys Glu Phe Thr Asn Leu Lys Gly Asn Leu Glu Lys 
    770                 775                 780                 


Tyr His Ser Ala Asn Glu Val Asn Ile Phe Ser Asp Glu Leu Glu Leu 
785                 790                 795                 800 


Ile Asn Phe Leu Asn Leu Asp Asn Asn Lys Val Lys Glu Asp Phe Glu 
                805                 810                 815     


Phe Glu Ala Asp Glu Ile Gly Lys Phe Leu Asn Phe Asn Gly Asn Lys 
            820                 825                 830         


Ile Lys Asn Arg Glu Glu Leu Lys Lys Phe Asp Thr Thr Lys Met Tyr 
        835                 840                 845             


Phe Tyr Lys Glu Asn Ile Ile Lys Tyr Arg Ala Tyr Tyr Asn Ile Lys 
    850                 855                 860                 


Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala Gly 
865                 870                 875                 880 


Tyr Lys Ile Ser Ile Glu Glu Leu Lys Lys Tyr Ser Asn Lys Lys Asn 
                885                 890                 895     


Glu Ile Glu Lys Asn His Lys Met Gln Glu Asn Leu His Arg Lys Tyr 
            900                 905                 910         


Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Glu Ser 
        915                 920                 925             


Tyr Lys Gln Ala Ile Lys Asn Ile Glu Glu Tyr Thr His Leu Lys Asn 
    930                 935                 940                 


Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu Arg 
945                 950                 955                 960 


Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp Leu 
                965                 970                 975     


Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu Glu 
            980                 985                 990         


Ile Phe Asn Phe Glu Asn Lys Lys  Asn Met Lys Tyr Lys  Ser Gly Gln 
        995                 1000                 1005             


Ile Val  Glu Lys Tyr Ile Lys  Phe Tyr Lys Glu Leu  His Gln Asn 
    1010                 1015                 1020             


Asp Glu  Val Lys Ile Asn Lys  Tyr Ser Ser Ala Asn  Ile Lys Val 
    1025                 1030                 1035             


Leu Lys  Gln Glu Lys Lys Asp  Leu Tyr Ile Arg Asn  Tyr Ile Ala 
    1040                 1045                 1050             


His Phe  Asn Tyr Ile Pro His  Ala Glu Ile Ser Leu  Leu Glu Val 
    1055                 1060                 1065             


Leu Glu  Asn Leu Arg Lys Leu  Leu Ser Tyr Asp Arg  Lys Leu Lys 
    1070                 1075                 1080             


Asn Ala  Val Met Lys Ser Val  Val Asp Ile Leu Lys  Glu Tyr Gly 
    1085                 1090                 1095             


Phe Val  Val Lys Phe Lys Ile  Gly Ala Asp Lys Lys  Ile Glu Ile 
    1100                 1105                 1110             


Gln Ser  Leu Lys Ser Glu Glu  Ile Val His Leu Lys  Lys Leu Lys 
    1115                 1120                 1125             


Leu Lys  Asp Asn Asp Lys Lys  Lys Glu Pro Ile Lys  Thr Tyr Arg 
    1130                 1135                 1140             


Asn Ser  Lys Glu Leu Cys Lys  Leu Val Lys Val Met  Phe Glu Tyr 
    1145                 1150                 1155             


Lys Met  Glu Glu Lys Ser Ser  Glu Lys 
    1160                 1165         


<210>  663
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  663

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  664
<211>  1167
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  664

Met Lys Val Thr Lys Val Gly Gly Ile Ser His Lys Lys Tyr Thr Ser 
1               5                   10                  15      


Glu Gly Arg Leu Val Lys Ser Glu Ser Glu Glu Asn Arg Thr Asp Glu 
            20                  25                  30          


Arg Leu Ser Ala Leu Leu Asn Met Arg Leu Asp Met Tyr Ile Lys Asn 
        35                  40                  45              


Pro Ser Asn Thr Glu Thr Lys Glu Asn Lys Lys Arg Ile Gly Lys Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Met Val Tyr Leu Lys Asp Asn Thr Leu 
65                  70                  75                  80  


Ser Leu Lys Asn Gly Lys Lys Glu Asn Ile Asp Arg Glu Tyr Ser Glu 
                85                  90                  95      


Thr Asp Ile Ser Glu Tyr Asp Val Arg Asp Ser Lys Asn Phe Ala Val 
            100                 105                 110         


Leu Lys Lys Ile Tyr Leu Asn Glu Asn Val Asn Ser Glu Glu Leu Glu 
        115                 120                 125             


Val Phe Arg Lys Asp Ile Lys Lys Lys Leu Asn Lys Ile Asn Ser Leu 
    130                 135                 140                 


Lys Tyr Ser Phe Glu Lys Asn Lys Ala Asn Tyr Gln Lys Ile Asn Glu 
145                 150                 155                 160 


Asn Asn Ile Glu Lys Val Glu Gly Lys Ser Lys Arg Asn Ile Ile Tyr 
                165                 170                 175     


Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asp Ala Tyr Val Ser Asn Val 
            180                 185                 190         


Lys Glu Ala Phe Asp Lys Leu Tyr Lys Glu Glu Asp Ile Ala Lys Leu 
        195                 200                 205             


Val Leu Lys Ile Glu Asn Leu Thr Lys Leu Glu Lys Ser Lys Ile Arg 
    210                 215                 220                 


Glu Phe Tyr His Glu Ile Ile Gly Arg Lys Asn Asp Lys Glu Asn Phe 
225                 230                 235                 240 


Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Met Lys Glu 
                245                 250                 255     


Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser Gln Val 
            260                 265                 270         


Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Glu Asn Val 
        275                 280                 285             


Lys Tyr Val Phe Cys His Phe Val Glu Ile Glu Met Ser Lys Leu Leu 
    290                 295                 300                 


Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp Lys Val 
305                 310                 315                 320 


Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu Asn Lys 
                325                 330                 335     


Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys Tyr Asn 
            340                 345                 350         


Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile Ala Arg 
        355                 360                 365             


Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val Ser Ser 
    370                 375                 380                 


Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn Lys Asp 
385                 390                 395                 400 


Asp Ile Thr Gly Lys Met Arg Gly Lys Thr Arg Ile Glu Ser Lys Thr 
                405                 410                 415     


Gly Glu Glu Lys Tyr Ile Pro Gly Glu Val Asp Gln Ile Tyr Tyr Glu 
            420                 425                 430         


Asn Lys Gln Asn Glu Val Lys Asn Lys Leu Lys Met Phe Tyr Gly Tyr 
        435                 440                 445             


Asp Phe Asp Met Asp Asn Lys Lys Glu Ile Glu Asp Phe Phe Ala Asn 
    450                 455                 460                 


Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe Asn 
465                 470                 475                 480 


Leu Asp Leu Asp Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Val Pro 
                485                 490                 495     


Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys Lys 
            500                 505                 510         


Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe Arg 
        515                 520                 525             


Tyr Leu Glu Lys Asp Arg Ile Leu Asp Tyr Leu Arg Ser Thr Arg Phe 
    530                 535                 540                 


Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys Leu 
545                 550                 555                 560 


Tyr Asp Arg Ile Asp Asp Leu Lys Ile Ser Leu Asn Ile Tyr Trp Lys 
                565                 570                 575     


Thr Pro Lys Thr Asn Asp Asp Ile Lys Thr Lys Glu Ile Thr Asp Ala 
            580                 585                 590         


Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Lys Phe Leu Asp Tyr 
        595                 600                 605             


Phe Met Ser Arg Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Val Ile 
    610                 615                 620                 


Lys Leu Asn Lys Asn Asn Lys Lys Asn Val Lys Thr Gly Phe Tyr Lys 
625                 630                 635                 640 


Leu Gln Lys Phe Glu Asn Leu Glu Ala Arg Ser Pro Lys Glu Tyr Leu 
                645                 650                 655     


Ala Lys Val Gln Ser Leu Tyr Ile Ile Asn Val Ala Asn Gln Asp Glu 
            660                 665                 670         


Glu Glu Lys Asn Thr Tyr Ile Asp Phe Ile Gln Lys Val Phe Leu Lys 
        675                 680                 685             


Gly Phe Ile Thr Tyr Leu Ala Asn Asn Arg Arg Leu Ser Leu Met Tyr 
    690                 695                 700                 


Ile Gly Ser Asp Glu Glu Val Asn Asn Ser Leu Ala Glu Lys Lys Gln 
705                 710                 715                 720 


Glu Phe Asp Lys Phe Trp Arg Lys Tyr Glu Glu Asn Asn Asp Ile Glu 
                725                 730                 735     


Ile Pro Asp Glu Ile Asn Glu Phe Leu Lys Glu Ile Lys Leu Gly Lys 
            740                 745                 750         


Ile Leu Lys Asn Ser Ala Lys Leu Asn Ile Phe Tyr Leu Ile Leu Lys 
        755                 760                 765             


Leu Leu Asn Asn Lys Glu Phe Thr Asn Leu Lys Gly Asn Leu Glu Lys 
    770                 775                 780                 


Tyr His Ser Ala Asn Glu Val Asn Ile Phe Ser Asp Glu Leu Glu Leu 
785                 790                 795                 800 


Ile Asn Phe Leu Asn Leu Asp Asn Asn Lys Val Lys Glu Asp Phe Glu 
                805                 810                 815     


Phe Glu Ala Asp Glu Ile Gly Lys Phe Leu Asn Phe Asn Gly Asn Lys 
            820                 825                 830         


Ile Lys Asn Arg Glu Glu Leu Lys Lys Phe Asp Thr Thr Lys Met Tyr 
        835                 840                 845             


Phe Tyr Lys Glu Asn Ile Ile Lys Tyr Arg Ala Tyr Tyr Asn Ile Lys 
    850                 855                 860                 


Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala Gly 
865                 870                 875                 880 


Tyr Lys Ile Ser Ile Glu Glu Leu Lys Lys Tyr Ser Asn Lys Lys Asn 
                885                 890                 895     


Glu Ile Glu Lys Asn His Lys Met Gln Glu Asn Leu His Arg Lys Tyr 
            900                 905                 910         


Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Glu Ser 
        915                 920                 925             


Tyr Lys Gln Ala Ile Lys Asn Ile Glu Glu Tyr Thr His Leu Lys Asn 
    930                 935                 940                 


Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu Arg 
945                 950                 955                 960 


Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp Leu 
                965                 970                 975     


Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu Glu 
            980                 985                 990         


Ile Phe Asn Phe Glu Asn Lys Lys  Asn Met Lys Tyr Lys  Ser Gly Gln 
        995                 1000                 1005             


Ile Val  Glu Lys Tyr Ile Lys  Phe Tyr Lys Glu Leu  His Gln Asn 
    1010                 1015                 1020             


Asp Glu  Val Lys Ile Asn Lys  Tyr Ser Ser Ala Asn  Ile Lys Val 
    1025                 1030                 1035             


Leu Lys  Gln Glu Lys Lys Asp  Leu Tyr Ile Arg Asn  Tyr Ile Ala 
    1040                 1045                 1050             


His Phe  Asn Tyr Ile Pro His  Ala Glu Ile Ser Leu  Leu Glu Val 
    1055                 1060                 1065             


Leu Glu  Asn Leu Arg Lys Leu  Leu Ser Tyr Asp Arg  Lys Leu Lys 
    1070                 1075                 1080             


Asn Ala  Val Met Lys Ser Val  Val Asp Ile Leu Lys  Glu Tyr Gly 
    1085                 1090                 1095             


Phe Val  Val Lys Phe Lys Ile  Gly Ala Asp Lys Lys  Ile Glu Ile 
    1100                 1105                 1110             


Gln Ser  Leu Lys Ser Glu Glu  Ile Val His Leu Lys  Lys Leu Lys 
    1115                 1120                 1125             


Leu Lys  Asp Asn Asp Lys Lys  Lys Glu Pro Ile Lys  Thr Tyr Arg 
    1130                 1135                 1140             


Asn Ser  Lys Glu Leu Cys Lys  Leu Val Lys Val Met  Phe Glu Tyr 
    1145                 1150                 1155             


Lys Met  Glu Glu Lys Ser Ser  Glu Lys 
    1160                 1165         


<210>  665
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  665

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Thr Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Tyr Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asn Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Val Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Val 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Lys Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Met 
    690                 695                 700                 


Tyr Ile Gly Asn Asp Glu Gln Ile Asn Thr Ser Leu Ala Gly Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Lys Ile Leu Lys Tyr Thr Glu Ser Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Lys Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Leu Lys Glu Leu Lys Glu Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn Tyr Thr Met Gln Gln Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Lys Lys Asp Glu Lys Phe Asn Asp Glu Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Ile Met Lys Ser  Val Val Asn Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Lys Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Lys Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Glu  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  666
<211>  1135
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  666

Met Lys Ile Thr Lys Ile Asp Gly Ile Ser His Lys Lys Tyr Lys Glu 
1               5                   10                  15      


Lys Gly Lys Leu Ile Lys Ser Asn Glu Ile Glu Lys Asp Val Thr Glu 
            20                  25                  30          


Glu Arg Phe Asn Asp Ile Glu Val Lys Thr Thr Glu Leu Phe Gln Lys 
        35                  40                  45              


Thr Leu Asp Phe Tyr Val Lys Asn Tyr Glu Lys Cys Glu Glu Gln Asn 
    50                  55                  60                  


Lys Glu Arg Arg Glu Lys Ala Lys Asn Tyr Phe Ser Lys Val Lys Leu 
65                  70                  75                  80  


Ile Val Asp Asn Lys Lys Ile Thr Ile Phe Asn Glu Asn Thr Glu Lys 
                85                  90                  95      


Ile Glu Ile Glu Gly Phe Asn Glu Tyr Asp Val Arg Asp Glu Lys Tyr 
            100                 105                 110         


Phe Asn Val Leu Asn Lys Ile Leu Lys Glu Glu Asn Cys Thr Glu Glu 
        115                 120                 125             


Asp Leu Glu Val Phe Glu Asn Asp Leu Gln Lys Lys Leu Asn Gln Ile 
    130                 135                 140                 


Gln Ser Ile Lys Asn Ser Leu Glu Glu Asn Lys Ala His Phe Lys Lys 
145                 150                 155                 160 


Glu Ser Val Asn Asn Thr Ala Asp Arg Val Lys Gly Asn Asn Lys Lys 
                165                 170                 175     


Ser Leu Phe Tyr Glu Tyr Tyr Arg Asn Ser Ser Lys His Gln Glu Tyr 
            180                 185                 190         


Val Asn Asn Ile Phe Glu Ala Phe Asp Lys Leu Tyr Ser Asn Ser His 
        195                 200                 205             


Glu Asp Met Asn Asn Leu Phe Ser Ala Ile Thr Lys Asp Ser Asn Asp 
    210                 215                 220                 


Arg Asn Ile Lys Lys Ile Arg Glu Ala Tyr His Glu Ile Leu Asn Lys 
225                 230                 235                 240 


Asn Lys Ile Glu Phe Gly Glu Glu Leu Tyr Lys Lys Ile Gln Asp Asn 
                245                 250                 255     


Ile Asn Asn Phe Asp Lys Leu Leu Glu Ile Glu Pro Glu Ile Lys Glu 
            260                 265                 270         


Leu Thr Lys Ser Gln Ile Phe Tyr Lys Tyr Tyr Ile Asp Lys Val Ser 
        275                 280                 285             


Leu Asp Gly Thr Asn Ile Lys His Cys Phe Ser His Leu Val Glu Ile 
    290                 295                 300                 


Glu Val Asn Gln Leu Leu Lys Asn Tyr Val Tyr Ser Lys Arg Ser Thr 
305                 310                 315                 320 


Asn Lys Glu Lys Leu Glu Asn Ile Phe Glu Tyr Cys Lys Leu Lys Asn 
                325                 330                 335     


Leu Val Lys Asn Lys Leu Val Asn Lys Leu Asn Ser Tyr Ile Arg Asn 
            340                 345                 350         


Cys Gly Lys Tyr Asn Ser Tyr Ile Asn Asn Asn Asp Val Val Asn Ser 
        355                 360                 365             


Glu Lys Ile Ser Glu Ile Arg Thr Lys Glu Ala Phe Leu Arg Ser Ile 
    370                 375                 380                 


Ile Gly Val Ser Ser Ser Ala Tyr Phe Ser Leu Arg Asn Ile Leu Asn 
385                 390                 395                 400 


Thr Asp Asn Thr Gln Asp Ile Thr Asn Lys Val Lys Gly Glu Val Glu 
                405                 410                 415     


Lys Leu Tyr Gln Glu Asn Lys Lys Val Lys Leu Glu Glu Arg Leu Lys 
            420                 425                 430         


Leu Phe Phe Gly Asn Asn Phe Asp Ile Asn Asn Gln Gln Glu Ile Glu 
        435                 440                 445             


Asp Phe Leu Met Asn Ile Asp Lys Ile Ile Ser Asn Ile Arg His Glu 
    450                 455                 460                 


Ile Ile His Phe Lys Ile Glu Ala Asn Ala His Ser Ile Phe Asp Phe 
465                 470                 475                 480 


Asn Asn Val Thr Leu Gly Asn Lys Ala Lys Asn Ile Phe Asn Asn Glu 
                485                 490                 495     


Ile Asn Glu Glu Arg Ile Lys Phe Lys Ile Phe Lys Gln Leu Asn Ser 
            500                 505                 510         


Ala Asn Val Phe Asp Tyr Leu Ser Asp Glu Asn Ile Thr Glu Tyr Met 
        515                 520                 525             


Gly Lys Val Ile Phe Ser Phe Thr Asn Arg Asn Ile Pro Phe Val Pro 
    530                 535                 540                 


Ser Phe Arg Lys Ile Tyr Asn Arg Val Gln Asp Leu Ala Asn Ser Leu 
545                 550                 555                 560 


Lys Ile Lys Glu Trp Lys Ile Ser Asp Glu Ser Glu Gly Lys Asp Ala 
                565                 570                 575     


Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Glu Glu Phe Leu Asp Glu 
            580                 585                 590         


Phe Leu Asn Glu Glu Asn Gly Ile Phe Ile Ser Ile Lys Asp Lys Ile 
        595                 600                 605             


Ile Glu Leu Asn Arg Asn Gln Asn Lys Arg Thr Gly Phe Tyr Lys Leu 
    610                 615                 620                 


Glu Lys Phe Glu Lys Ile Glu Glu Lys Asn Pro Lys Lys Tyr Leu Glu 
625                 630                 635                 640 


Ile Ile Gln Ser Leu Tyr Met Ile Asn Ile Glu Glu Ile Asp Asn Glu 
                645                 650                 655     


Glu Lys Asn Ile Phe Leu Asp Phe Ile Gln Lys Ile Phe Leu Lys Gly 
            660                 665                 670         


Phe Phe Glu Phe Ile Lys Asn Asn Tyr Asn Tyr Leu Leu Glu Leu Lys 
        675                 680                 685             


Lys Ile Gln Asp Lys Lys Asn Ile Phe Asp Ser Glu Met Ser Glu Tyr 
    690                 695                 700                 


Ile Ala Gly Glu Lys Thr Leu Glu Asp Val Gly Glu Ile Asn Glu Ile 
705                 710                 715                 720 


Ile Gln Lys Ile Glu Ile Met Lys Ile Asp Lys Ile Leu Asn Leu Thr 
                725                 730                 735     


Asp Lys Ile Asn Cys Phe Tyr Leu Leu Leu Lys Leu Leu Asn Tyr Lys 
            740                 745                 750         


Glu Ile Thr Glu Leu Lys Gly Asn Leu Glu Lys Tyr Gln Ile Leu Ser 
        755                 760                 765             


Lys Thr Asp Ile Tyr Glu Lys Glu Leu Ile Leu Leu Asn Ile Val Asn 
    770                 775                 780                 


Leu Asp Asn Asn Lys Val Lys Ile Glu Lys Phe Lys Ile Ser Ala Glu 
785                 790                 795                 800 


Glu Ile Gly Lys Phe Ile Glu Lys Ile Ser Arg Asn Lys Lys Ile Lys 
                805                 810                 815     


Thr Phe Glu Glu Leu Arg Asn Phe Glu Lys Arg Glu Asn Thr Gly Glu 
            820                 825                 830         


Tyr Tyr Asn Val Tyr Ser Asp Asp Lys Asn Ile Lys Asn Ile Arg Asn 
        835                 840                 845             


Leu Tyr Asn Ile Lys Lys Tyr Gly Met Leu Asp Leu Leu Glu Arg Ile 
    850                 855                 860                 


Ser Glu Lys Ser Asn Tyr Cys Ile Lys Lys Glu Asp Leu Glu Glu Tyr 
865                 870                 875                 880 


Ser Glu Leu Arg Lys Gln Leu Glu Asp Glu Lys Thr Asn Phe Tyr Lys 
                885                 890                 895     


Ile Gln Lys Asp Leu His Tyr Glu Tyr Gln Lys Lys Tyr Lys Asn Phe 
            900                 905                 910         


Ser Lys Lys Asn Asn Pro Glu Asp Tyr Glu Lys Tyr Lys Glu Ser Ile 
        915                 920                 925             


Lys Asn Ile Glu Lys Tyr Val His Leu Lys Asn Lys Ile Glu Phe Asn 
    930                 935                 940                 


Glu Leu Asn Leu Leu Gln Ser Leu Leu Leu Lys Ile Leu His Arg Leu 
945                 950                 955                 960 


Val Gly Phe Thr Ser Ile Trp Glu Arg Asp Leu Arg Phe Arg Leu Ile 
                965                 970                 975     


Gly Glu Phe Pro Asp Glu Leu Asp Val Glu Asp Ile Phe Asp His Arg 
            980                 985                 990         


Glu Arg Tyr Arg Gly Thr Arg Gly  Gln Ile Cys Lys Lys  Tyr Asp Gln 
        995                 1000                 1005             


Phe Ile  Ser Val His Ile Glu  Tyr Gln Asn Asn Asn  Lys Met Lys 
    1010                 1015                 1020             


Asn Ile  Lys Phe Asp Asp Asn  Asn Pro Ile Arg Asn  Tyr Ile Ala 
    1025                 1030                 1035             


His Phe  Asn Tyr Leu Pro Thr  Pro Lys Tyr Ser Ile  Leu Lys Met 
    1040                 1045                 1050             


Leu Gly  Lys Leu Arg Glu Leu  Leu Asp Tyr Asp Arg  Lys Leu Lys 
    1055                 1060                 1065             


Asn Ala  Val Met Lys Ser Ile  Lys Asp Ile Leu Glu  Glu Tyr Gly 
    1070                 1075                 1080             


Phe Lys  Ala Glu Phe Val Ile  Asn Pro Asp Lys Glu  Ile Ile Leu 
    1085                 1090                 1095             


Asn Ser  Val Lys Ser Val Glu  Ile Ile His Leu Lys  Lys Asn Asp 
    1100                 1105                 1110             


Leu Asn  Ser His Arg Asn Ser  Glu Asp Leu Cys Lys  Leu Val Lys 
    1115                 1120                 1125             


Ala Met  Leu Glu Tyr Ser Glu  
    1130                 1135 


<210>  667
<211>  1101
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  667

Met Arg Ile Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Ile Tyr Ser Glu 
            20                  25                  30          


Gln Ala Val Ser Asn Glu Thr Asn Asn Ile Leu Pro Val Lys Lys Met 
        35                  40                  45              


Asp Ser Phe Asn Leu Ser Ile Leu Asn Lys Thr Ile Ile Lys Phe Glu 
    50                  55                  60                  


Thr Val Lys Lys Gln Lys Leu Asn Leu Asp Gln Tyr Lys Ile Val Glu 
65                  70                  75                  80  


Lys Ile Phe Lys Tyr Pro Lys Gln Glu Leu Pro Lys Gln Ile Asn Ala 
                85                  90                  95      


Glu Glu Ile Leu Gln Phe Leu Asn His Lys Phe Gln Glu Pro Val Lys 
            100                 105                 110         


Tyr Trp Lys Asn Gly Lys Glu Glu Ser Phe Asn Leu Thr Leu Leu Ile 
        115                 120                 125             


Val Glu Ala Val Lys Thr Gln Glu Lys Arg Lys Leu Gln Pro Tyr Tyr 
    130                 135                 140                 


Asp Trp Lys Thr Trp Tyr Ile Gln Thr Lys Ser Asp Leu Leu Lys Lys 
145                 150                 155                 160 


Ser Ile Glu Asn Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg 
                165                 170                 175     


Lys Lys Ala Leu Leu Ala Trp Glu Thr Glu Phe Thr Thr Ser Gly Ser 
            180                 185                 190         


Ile Asp Leu Thr His Phe His Lys Val Tyr Met Thr Asp Val Leu Cys 
        195                 200                 205             


Thr Ala Leu Gln Lys Val Glu Pro Ser Ala Asp Glu Arg Gly Lys Met 
    210                 215                 220                 


Asn Ser Asn Ala Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Asn His 
225                 230                 235                 240 


Gln Pro Ala Ile Phe Gly Thr Arg Glu Ala Pro Asn Glu Val Asn Arg 
                245                 250                 255     


Ala Asp Asn Gln Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu 
            260                 265                 270         


Glu His Tyr Phe Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Ala Asp 
        275                 280                 285             


Asp Ile Ser His Tyr Leu Lys Ala Gln Thr Leu Lys Thr Thr Ile Glu 
    290                 295                 300                 


Lys Gln Leu Val Asn Ala Ile Arg Ala Asn Ile Ile Gln Gln Gly Lys 
305                 310                 315                 320 


Thr Asn His His Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile 
                325                 330                 335     


Arg Ile Lys Thr Asn Glu Ala Phe Val Leu Asn Leu Ile Gly Thr Cys 
            340                 345                 350         


Ala Phe Ala Ala Asn Asn Ile Arg Asn Met Val Asp Lys Glu Gln Ile 
        355                 360                 365             


Ser Asp Ile Leu Gly Lys Arg Glu Phe Ile Asp Ser Leu Thr Lys Ser 
    370                 375                 380                 


Arg Ile Ser Ser Gln Leu Tyr Ser Phe Phe Phe Gly Glu Asn Leu Ser 
385                 390                 395                 400 


Thr Asn Lys Ala Glu Lys Glu Thr Gln Leu Trp Gly Ile Arg Gly Ala 
                405                 410                 415     


Val Gln Gln Ile Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu 
            420                 425                 430         


Thr Thr Ile Phe Asn Ile Cys Lys Phe Glu Asn Pro Thr Asp Ala Asp 
        435                 440                 445             


Pro Lys Gln Gln Thr Asn Tyr Val Asp Ser Ile Tyr Lys Thr Leu Phe 
    450                 455                 460                 


Ile Lys Glu Leu Glu Lys Ile Pro Glu Ala Phe Ala Gln Gln Leu Lys 
465                 470                 475                 480 


Thr Gly Gly Ala Leu Ser Tyr Tyr Thr Val Glu Asn Leu Lys Thr Leu 
                485                 490                 495     


Leu Thr Thr Phe Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala 
            500                 505                 510         


Pro Gly Phe Lys Lys Val Leu Asn Gly Gly Ile Asn Tyr Gln Asn Ala 
        515                 520                 525             


Lys Gln Asp Glu Ser Phe Tyr Glu Leu Met Leu Glu Arg Tyr Leu Arg 
    530                 535                 540                 


Lys Glu Asn Phe Ala Glu Glu Ala Tyr Asn Ala Arg Tyr Phe Leu Leu 
545                 550                 555                 560 


Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Lys Phe Thr Ala Asp Arg 
                565                 570                 575     


Lys Ala Phe Ala Asp Ser Val Gly Phe Val Gln Leu Gln Asn Arg Lys 
            580                 585                 590         


Gln Ala Glu Asn Ser Lys Arg Pro Lys Ala Phe Ala Phe Glu Ala Val 
        595                 600                 605             


Arg Pro Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala Tyr Val 
    610                 615                 620                 


Gln Ser Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys Ala Thr 
625                 630                 635                 640 


Asp Glu Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val Phe Ile 
                645                 650                 655     


Lys Gly Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe Val Gln 
            660                 665                 670         


Val Pro Gln Pro Gln Leu Thr Thr Thr Asp Ser Asn Gln Gln Lys Ala 
        675                 680                 685             


Asp Lys Leu Asn Gln Leu Glu Ala Ser Ile Thr Ala Asp Cys Lys Leu 
    690                 695                 700                 


Thr Ala Gln Tyr Ala Lys Thr Asp Asp Ala Thr His Ile Ala Phe Tyr 
705                 710                 715                 720 


Val Phe Cys Lys Leu Leu Asp Ala Gly His Leu Ser Asn Leu Arg Asn 
                725                 730                 735     


Glu Leu Ile Lys Phe Arg Gly Ser Val Lys Asp Phe Asp Phe His His 
            740                 745                 750         


Leu Leu Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val Val Pro 
        755                 760                 765             


Thr Asp Tyr Arg Asp Leu Tyr Ser Ser Gly Ala Asp Cys Leu Ala Arg 
    770                 775                 780                 


Leu Arg Pro Phe Ile Glu Gln Gly Ala Asp Ile Lys Asn Trp Ser Asp 
785                 790                 795                 800 


Leu Tyr Val Gln Thr Asp Lys Gln Thr Pro Val Ile His Ala Gly Ile 
                805                 810                 815     


Glu Leu Ser Val Lys Tyr Gly Thr Thr Ala Leu Leu Glu Gln Leu Ile 
            820                 825                 830         


Thr Cys Asn Pro Lys Phe Arg Val Met Glu Asp Asn Phe Thr Lys Trp 
        835                 840                 845             


Ser Ala Gln Lys Lys Glu Ile Glu Glu Lys Val Asn Lys His Thr Asn 
    850                 855                 860                 


Leu His Gln Gln Trp Val Glu Ala Lys Glu Lys Asp Asp Arg Glu Arg 
865                 870                 875                 880 


Val Lys Ser Lys Lys Asn Phe Val Arg Glu Tyr Val Lys Lys Asn Tyr 
                885                 890                 895     


Val Asp Tyr Ile Asn Asn Cys Ile Glu Ile Asn Asn Tyr Asn Trp Leu 
            900                 905                 910         


Asp Asn Lys Leu His Phe Val His Leu Asn His Leu His His Leu Thr 
        915                 920                 925             


Ile Asp Ile Leu Gly Arg Met Ala Gly Phe Val Ala Leu Trp Glu Arg 
    930                 935                 940                 


Asp Phe Gln Tyr Ile Thr Lys Tyr Thr Ala Ala Lys Glu Gly Thr Asp 
945                 950                 955                 960 


Ala Leu Ser Phe Asp Gly Gly Leu Pro Arg Leu Lys Asp Lys Gln Glu 
                965                 970                 975     


Tyr Tyr Asn Lys Leu Phe Leu Ser Asp Lys Tyr Thr Lys Val Arg Asn 
            980                 985                 990         


His Ile Ala His Phe Asn Tyr Leu  Thr Lys Asp Ala Ala  Asp Phe Ala 
        995                 1000                 1005             


Leu Leu  Asp Leu Ile Asn Glu  Leu Arg Glu Leu Leu  His Tyr Gly 
    1010                 1015                 1020             


Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ala Phe Ile  Asp Leu Phe 
    1025                 1030                 1035             


Glu Lys  His Gly Met Ile Leu  Lys Leu Lys Leu Asn  Thr Asp His 
    1040                 1045                 1050             


Gln Leu  Val Val Glu Ser Ile  Glu Pro Lys Lys Ile  Tyr His Leu 
    1055                 1060                 1065             


Gly Ser  Thr Ala Lys Asp Lys  Pro Glu Tyr Gln Tyr  Thr Thr Asn 
    1070                 1075                 1080             


Gln Val  Met Thr Val Tyr Cys  Asn Met Cys Arg Ser  Leu Leu Glu 
    1085                 1090                 1095             


Met Lys  Lys 
    1100     


<210>  668
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  668

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  669
<211>  1167
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  669

Met Lys Val Thr Lys Val Gly Gly Ile Ser His Lys Lys Tyr Thr Ser 
1               5                   10                  15      


Glu Gly Arg Leu Val Lys Ser Glu Ser Glu Glu Asn Arg Thr Asp Glu 
            20                  25                  30          


Arg Leu Ser Ala Leu Leu Asn Met Arg Leu Asp Met Tyr Ile Lys Asn 
        35                  40                  45              


Pro Ser Asn Thr Glu Thr Lys Glu Asn Lys Lys Arg Ile Gly Lys Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Met Val Tyr Leu Lys Asp Asn Thr Leu 
65                  70                  75                  80  


Ser Leu Lys Asn Gly Lys Lys Glu Asn Ile Asp Arg Glu Tyr Ser Glu 
                85                  90                  95      


Thr Asp Ile Ser Glu Tyr Asp Val Arg Asp Ser Lys Asn Phe Ala Val 
            100                 105                 110         


Leu Lys Lys Ile Tyr Leu Asn Glu Asn Val Asn Ser Glu Glu Leu Glu 
        115                 120                 125             


Val Phe Arg Lys Asp Ile Lys Lys Lys Leu Asn Lys Ile Asn Ser Leu 
    130                 135                 140                 


Lys Tyr Ser Phe Glu Lys Asn Lys Ala Asn Tyr Gln Lys Ile Asn Glu 
145                 150                 155                 160 


Asn Asn Ile Glu Lys Val Glu Gly Lys Ser Lys Arg Asn Ile Ile Tyr 
                165                 170                 175     


Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asp Ala Tyr Val Ser Asn Val 
            180                 185                 190         


Lys Glu Ala Phe Asp Lys Leu Tyr Lys Glu Glu Asp Ile Ala Lys Leu 
        195                 200                 205             


Val Leu Lys Ile Glu Asn Leu Thr Lys Leu Glu Lys Ser Lys Ile Arg 
    210                 215                 220                 


Glu Phe Tyr His Glu Ile Ile Gly Arg Lys Asn Asp Lys Glu Asn Phe 
225                 230                 235                 240 


Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Met Lys Glu 
                245                 250                 255     


Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser Gln Val 
            260                 265                 270         


Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Glu Asn Val 
        275                 280                 285             


Lys Tyr Val Phe Cys His Phe Val Glu Ile Glu Met Ser Lys Leu Leu 
    290                 295                 300                 


Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp Lys Val 
305                 310                 315                 320 


Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu Asn Lys 
                325                 330                 335     


Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys Tyr Asn 
            340                 345                 350         


Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile Ala Arg 
        355                 360                 365             


Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val Ser Ser 
    370                 375                 380                 


Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn Lys Asp 
385                 390                 395                 400 


Asp Ile Thr Gly Lys Met Arg Gly Lys Thr Arg Ile Glu Ser Lys Thr 
                405                 410                 415     


Gly Glu Glu Lys Tyr Ile Pro Gly Glu Val Asp Gln Ile Tyr Tyr Glu 
            420                 425                 430         


Asn Lys Gln Asn Glu Val Lys Asn Lys Leu Lys Met Phe Tyr Gly Tyr 
        435                 440                 445             


Asp Phe Asp Met Asp Asn Lys Lys Glu Ile Glu Asp Phe Phe Ala Asn 
    450                 455                 460                 


Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe Asn 
465                 470                 475                 480 


Leu Asp Leu Asp Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Val Pro 
                485                 490                 495     


Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys Lys 
            500                 505                 510         


Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe Arg 
        515                 520                 525             


Tyr Leu Glu Lys Asp Arg Ile Leu Asp Tyr Leu Arg Ser Thr Arg Phe 
    530                 535                 540                 


Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys Leu 
545                 550                 555                 560 


Tyr Asp Arg Ile Asp Asp Leu Lys Ile Ser Leu Asn Ile Tyr Trp Lys 
                565                 570                 575     


Thr Pro Lys Thr Asn Asp Asp Ile Lys Thr Lys Glu Ile Thr Asp Ala 
            580                 585                 590         


Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Lys Phe Leu Asp Tyr 
        595                 600                 605             


Phe Met Ser Arg Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Val Ile 
    610                 615                 620                 


Lys Leu Asn Lys Asn Asn Lys Lys Asn Val Lys Thr Gly Phe Tyr Lys 
625                 630                 635                 640 


Leu Gln Lys Phe Glu Asn Leu Glu Ala Arg Ser Pro Lys Glu Tyr Leu 
                645                 650                 655     


Ala Lys Val Gln Ser Leu Tyr Ile Ile Asn Val Ala Asn Gln Asp Glu 
            660                 665                 670         


Glu Glu Lys Asn Thr Tyr Ile Asp Phe Ile Gln Lys Val Phe Leu Lys 
        675                 680                 685             


Gly Phe Ile Thr Tyr Leu Ala Asn Asn Arg Arg Leu Ser Leu Met Tyr 
    690                 695                 700                 


Ile Gly Ser Asp Glu Glu Val Asn Asn Ser Leu Ala Glu Lys Lys Gln 
705                 710                 715                 720 


Glu Phe Asp Lys Phe Trp Arg Lys Tyr Glu Glu Asn Asn Asp Ile Glu 
                725                 730                 735     


Ile Pro Asp Glu Ile Asn Glu Phe Leu Lys Glu Ile Lys Leu Gly Lys 
            740                 745                 750         


Ile Leu Lys Asn Ser Ala Lys Leu Asn Ile Phe Tyr Leu Ile Leu Lys 
        755                 760                 765             


Leu Leu Asn Asn Lys Glu Phe Thr Asn Leu Lys Gly Asn Leu Glu Lys 
    770                 775                 780                 


Tyr His Ser Ala Asn Glu Val Asn Ile Phe Ser Asp Glu Leu Glu Leu 
785                 790                 795                 800 


Ile Asn Phe Leu Asn Leu Asp Asn Asn Lys Val Lys Glu Asp Phe Glu 
                805                 810                 815     


Phe Glu Ala Asp Glu Ile Gly Lys Phe Leu Asn Phe Asn Gly Asn Lys 
            820                 825                 830         


Ile Lys Asn Arg Glu Glu Leu Lys Lys Phe Asp Thr Thr Lys Met Tyr 
        835                 840                 845             


Phe Tyr Lys Glu Asn Ile Ile Lys Tyr Arg Ala Tyr Tyr Asn Ile Lys 
    850                 855                 860                 


Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala Gly 
865                 870                 875                 880 


Tyr Lys Ile Ser Ile Glu Glu Leu Lys Lys Tyr Ser Asn Lys Lys Asn 
                885                 890                 895     


Glu Ile Glu Lys Asn His Lys Met Gln Glu Asn Leu His Arg Lys Tyr 
            900                 905                 910         


Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Glu Ser 
        915                 920                 925             


Tyr Lys Gln Ala Ile Lys Asn Ile Glu Glu Tyr Thr His Leu Lys Asn 
    930                 935                 940                 


Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu Arg 
945                 950                 955                 960 


Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp Leu 
                965                 970                 975     


Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu Glu 
            980                 985                 990         


Ile Phe Asn Phe Glu Asn Lys Lys  Asn Met Lys Tyr Lys  Ser Gly Gln 
        995                 1000                 1005             


Ile Val  Glu Lys Tyr Ile Lys  Phe Tyr Lys Glu Leu  His Gln Asn 
    1010                 1015                 1020             


Asp Glu  Val Lys Ile Asn Lys  Tyr Ser Ser Ala Asn  Ile Lys Val 
    1025                 1030                 1035             


Leu Lys  Gln Glu Lys Lys Asp  Leu Tyr Ile Arg Asn  Tyr Ile Ala 
    1040                 1045                 1050             


His Phe  Asn Tyr Ile Pro His  Ala Glu Ile Ser Leu  Leu Glu Val 
    1055                 1060                 1065             


Leu Glu  Asn Leu Arg Lys Leu  Leu Ser Tyr Asp Arg  Lys Leu Lys 
    1070                 1075                 1080             


Asn Ala  Val Met Lys Ser Val  Val Asp Ile Leu Lys  Glu Tyr Gly 
    1085                 1090                 1095             


Phe Val  Val Lys Phe Lys Ile  Gly Ala Asp Lys Lys  Ile Glu Ile 
    1100                 1105                 1110             


Gln Ser  Leu Lys Ser Glu Glu  Ile Val His Leu Lys  Lys Leu Lys 
    1115                 1120                 1125             


Leu Lys  Asp Asn Asp Lys Lys  Lys Glu Pro Ile Lys  Thr Tyr Arg 
    1130                 1135                 1140             


Asn Ser  Lys Glu Leu Cys Lys  Leu Val Lys Val Met  Phe Glu Tyr 
    1145                 1150                 1155             


Lys Met  Glu Glu Lys Ser Ser  Glu Lys 
    1160                 1165         


<210>  670
<211>  1385
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  670

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Pro Gly Thr Asp Thr 
            20                  25                  30          


Ile Asp Leu Asn Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Thr Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Asp Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Glu Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Gly Leu Phe Val Asn Ile 
                325                 330                 335     


Pro Asp Val Leu Met Lys Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Ile Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Ser Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg 
465                 470                 475                 480 


Asn Gly Ile Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Tyr Glu Asn 
                485                 490                 495     


Leu Gln Arg Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu 
            500                 505                 510         


Ala Arg Ala Val Cys Asp Met Ser Asn Leu Lys Asp Arg Glu Ser Asp 
        515                 520                 525             


Phe Leu Leu Trp Lys Lys Glu Asp Ile Ala Asp Lys Leu Lys Asn Lys 
    530                 535                 540                 


Asp Asp Met Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys 
545                 550                 555                 560 


Ser Ser Trp Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn 
                565                 570                 575     


Lys Tyr Asn Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile 
            580                 585                 590         


Tyr Cys Ala Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn 
        595                 600                 605             


Asn Glu Lys Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu 
    610                 615                 620                 


Thr Glu Phe Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn 
625                 630                 635                 640 


Leu Tyr Met Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Gln 
                645                 650                 655     


Leu Tyr Ser Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn 
            660                 665                 670         


Ser Val Phe Ile Arg Lys Asn Phe Pro Glu Asp Ile Thr Asn Val Leu 
        675                 680                 685             


Arg Tyr Gln Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr 
    690                 695                 700                 


Ser Ala Cys Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu 
705                 710                 715                 720 


Gln Ser Asp Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu 
                725                 730                 735     


Ser Trp Asp Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn 
            740                 745                 750         


His Phe Ser Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys 
        755                 760                 765             


Gln Ile Tyr Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys 
    770                 775                 780                 


Val Arg Ser Ser Asn Asp Ser Ile Phe Asp Lys Pro Ile Tyr His His 
785                 790                 795                 800 


Tyr Lys Val Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr 
                805                 810                 815     


Leu Lys Tyr Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys 
            820                 825                 830         


Ala Asn Glu Ile Arg Lys Ile Asp Lys Glu Arg Phe Leu Pro Asp Trp 
        835                 840                 845             


Thr Ser Thr Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln 
    850                 855                 860                 


Glu Leu Gln Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser 
865                 870                 875                 880 


Leu Asn Leu Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr 
                885                 890                 895     


Asp Ile Lys Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser 
            900                 905                 910         


Val Gln Asp Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val 
        915                 920                 925             


Cys Ser Leu Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe 
    930                 935                 940                 


Asn Asp Lys Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe 
945                 950                 955                 960 


Ser Asn Ala Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser 
                965                 970                 975     


Asn Glu Glu Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val 
            980                 985                 990         


Asn Arg Asn Ile Val His Ser Lys  Leu Phe Ala Ala Asp  His Ile Leu 
        995                 1000                 1005             


Arg Asp  Ile Val Glu Pro Val  Ser Lys Asp Asn Ile  Glu Glu Phe 
    1010                 1015                 1020             


Tyr Asp  Gln Lys Ala Glu Ile  Val Tyr Cys Lys Ile  Lys Gly Lys 
    1025                 1030                 1035             


Asp Ile  Thr Ala Glu Glu Gln  Lys Ala Val Leu Lys  Tyr Gln Lys 
    1040                 1045                 1050             


Leu Lys  Asn Arg Val Glu Leu  Arg Asp Ile Val Glu  Tyr Gly Glu 
    1055                 1060                 1065             


Ile Ile  Asn Glu Leu Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met 
    1070                 1075                 1080             


Arg Glu  Arg Asp Leu Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn 
    1085                 1090                 1095             


Cys Leu  Arg Asn Asn Ser Glu  Lys Lys Glu Ala Tyr  Gln Lys Ile 
    1100                 1105                 1110             


Glu Val  Asn Gly Asp Ser Ile  Lys Asp Ala Ile Leu  Tyr Gln Ile 
    1115                 1120                 1125             


Ile Gly  Met Tyr Val Asn Gly  Val Ala Val Tyr Ala  Pro Asp Glu 
    1130                 1135                 1140             


Lys Gly  Asp Ile Leu Lys Glu  Gln Cys Thr Lys Gly  Gly Ala Gly 
    1145                 1150                 1155             


Gly Lys  Ile Ser Ala Phe Asn  Arg Tyr Ser Glu Tyr  Leu Gly Leu 
    1160                 1165                 1170             


Asp Lys  Leu Thr Leu Tyr Asn  Ala Gly Leu Glu Ile  Phe Glu Val 
    1175                 1180                 1185             


Val Ala  Glu His Asp Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp 
    1190                 1195                 1200             


His Phe  Lys Tyr Tyr Leu Gly  Asp Tyr Arg Ser Met  Leu Ser Ile 
    1205                 1210                 1215             


Tyr Ser  Glu Val Phe Asp Arg  Phe Phe Thr Tyr Asp  Ile Lys Tyr 
    1220                 1225                 1230             


Gln Lys  Asn Val Leu Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His 
    1235                 1240                 1245             


Asn Val  Ile Val Glu Pro Val  Leu Glu Ser Gly Phe  Lys Thr Ile 
    1250                 1255                 1260             


Gly Lys  Gln Thr Thr Ser Gly  Ala Lys Leu Ser Ile  Arg Ser Ile 
    1265                 1270                 1275             


Lys Ser  Asp Thr Phe Gln Tyr  Lys Val Lys Gly Gly  Ser Leu Ile 
    1280                 1285                 1290             


Thr Asp  Ala Lys Asp Glu Arg  Tyr Leu Lys Thr Ile  Arg Lys Ile 
    1295                 1300                 1305             


Leu Tyr  Tyr Val Glu Asn Glu  Glu Asp Asn Leu Lys  Lys Ser Val 
    1310                 1315                 1320             


Val Val  Thr Asn Ala Asp Lys  Tyr Glu Lys Asn Lys  Glu Ser Asp 
    1325                 1330                 1335             


Asp Gln  Asn Lys Gln Lys Glu  Lys Lys Asn Lys Asp  Asn Lys Gly 
    1340                 1345                 1350             


Lys Lys  Asn Glu Glu Thr Lys  Ser Asp Ala Gly Lys  Asn Asn Asn 
    1355                 1360                 1365             


Glu Arg  Leu Ser Tyr Asn Pro  Phe Ala Asn Leu Asn  Phe Lys Leu 
    1370                 1375                 1380             


Pro Asn  
    1385 


<210>  671
<211>  1262
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  671

Met Arg Gly Gly His Met Lys Ile Thr Lys Ile Asp Gly Ile Ser His 
1               5                   10                  15      


Tyr Lys Glu Lys Glu Lys Gly Val Leu Lys Ala Lys Asp Val Leu Asn 
            20                  25                  30          


Glu Glu Ile Lys Glu Ile Val Lys Lys Arg Tyr Asp Ala Thr Ile Glu 
        35                  40                  45              


Ser Lys Ile Tyr Lys Glu Phe Ile Lys Leu Arg Lys Asn Arg Ile Glu 
    50                  55                  60                  


Gln Asn Asn Glu Lys Ser Val Leu Glu Leu Ile Lys Ser Asn Ile Asp 
65                  70                  75                  80  


Lys Asn Glu Lys Glu Ile Lys Thr Leu Leu Trp Asn Lys Phe Lys Ile 
                85                  90                  95      


Lys Glu Lys Asn Lys Lys Tyr Asp Lys Tyr Ile Leu Asp Glu Ile Lys 
            100                 105                 110         


Leu Asp Asn Asp Ile Lys Ile Tyr Glu Ser Ala Glu Ser Leu Tyr Phe 
        115                 120                 125             


Phe Ile Lys Glu Val Tyr Leu Gly Gln Asn Asn Lys Lys Trp Asn Ile 
    130                 135                 140                 


Ser Lys Ile Asp Leu Glu Lys Ile Met Glu Lys Asp Asn Asn Leu Ile 
145                 150                 155                 160 


Met Leu Gly Tyr Lys Leu Lys Lys Asn Ile Lys Glu Asp Glu Tyr Pro 
                165                 170                 175     


Tyr Leu Tyr Lys Asn Lys Asn Lys Gln Lys Ser Thr Pro Leu Tyr Thr 
            180                 185                 190         


Leu Leu Lys Lys Leu Ile Glu Lys Asn Lys Asn Ser Asn Gln Asn Ile 
        195                 200                 205             


Arg Glu Ser Glu Glu Tyr Glu Lys Ile Gln Lys Lys Phe Lys Glu Tyr 
    210                 215                 220                 


Lys Asn Ile Lys Ile Asn Leu Leu Val Lys Ser Ile Leu Asn Asn Lys 
225                 230                 235                 240 


Val Asn Ile Lys Tyr Asn Thr Ser Asn Asn Asn Ile Glu Glu Ser Asn 
                245                 250                 255     


Ser Lys Arg Glu Lys Glu Ile Ile Glu Phe Phe Lys Lys Met Ile Glu 
            260                 265                 270         


Glu Lys Asn Lys Ser Ile Leu Lys Asp Lys Leu Lys Leu Phe Arg Leu 
        275                 280                 285             


Glu Val Phe Phe Asp Glu Glu Phe Leu Glu Glu Ile Lys Lys Leu Leu 
    290                 295                 300                 


Asp Ser Gly Asp Ser Asp Lys Ser Asp Asn Lys Lys Ile Ala Glu Leu 
305                 310                 315                 320 


Arg Gly Lys Ile Phe Ser Arg Ile Arg Glu Lys Ile Lys Glu Asp Lys 
                325                 330                 335     


Asn Arg Tyr Ile Leu Lys Asn Ile Tyr Phe Leu Glu Leu Lys Lys Tyr 
            340                 345                 350         


Ile Glu Asn Asn Leu Ser His Lys Lys Glu Asn Asn Lys Asn Asn Ser 
        355                 360                 365             


Asn Ile Gly Glu Glu Lys Ser Lys Lys Leu Tyr Leu Lys Phe Leu Lys 
    370                 375                 380                 


Lys Val Leu Phe Ile Asp Asp Asn Asn Arg Ile Ser Ile Glu Lys Leu 
385                 390                 395                 400 


Lys Ser Arg Ile Asp Asp Asn Phe Lys Asn Leu Leu Ile Gln His Val 
                405                 410                 415     


Ile Glu Tyr Gly Lys Ile Lys Tyr Tyr Val Glu Asn Asp Asp Tyr Ile 
            420                 425                 430         


Lys Asn Ile Val Lys Asn Gly Glu Leu Lys Leu Glu Thr Glu Asn Leu 
        435                 440                 445             


Glu Tyr Ile Arg Ile Arg Glu Thr Leu Ile Arg Lys Met Ala Val Leu 
    450                 455                 460                 


Val Ser Phe Ala Ala Asn Ser Phe Tyr Asn Leu Phe Glu Asn Ile Thr 
465                 470                 475                 480 


Ser Asp Ile Leu Thr Ala Asn Ile Asn Leu Asp Ser Gly Val Ile Lys 
                485                 490                 495     


Ile Gly Asn Asn Arg Leu Lys Glu Lys Phe Leu Asn Tyr Phe Phe Tyr 
            500                 505                 510         


Ser Glu Glu Ile Leu Asp Lys Glu Asp Phe Leu Lys Ala Leu Lys Asp 
        515                 520                 525             


Ser Ile Tyr Asn Val Arg Asn Gly Val Asn His Phe Asp Lys Met Ile 
    530                 535                 540                 


Leu Gly Lys Tyr Asn Asn Gly Leu Asp Leu Lys Asp Ser Asp Thr Ile 
545                 550                 555                 560 


Lys Asp Tyr Phe Asn Phe Lys Lys Lys Glu Ile Gln Gln Asp Leu Arg 
                565                 570                 575     


Asp Arg Phe Ile Ser Asn Asn Leu Gln Tyr Tyr Tyr Thr Glu Asn Glu 
            580                 585                 590         


Ile Lys Lys Tyr Phe Glu Lys Tyr Lys Phe Glu Ile Leu Lys Thr Lys 
        595                 600                 605             


Ala Ser Phe Ala Pro Asn Phe Lys Arg Ile Leu Arg Lys Gly Glu Asn 
    610                 615                 620                 


Leu Ser Ile Ser Glu Ile Ser Asp Ile Tyr Asp Phe Phe Lys Arg Tyr 
625                 630                 635                 640 


Ser Glu Asn Ser Asp Lys Ser Ser Glu Tyr Asn Glu Phe Thr Lys Thr 
                645                 650                 655     


Arg Asn Phe Leu Leu Lys Glu Leu Tyr Tyr Asn Asn Phe Tyr Arg Glu 
            660                 665                 670         


Phe Leu Ser Asp Gly Thr Lys Phe Glu Glu Ala Val Lys Lys Val Lys 
        675                 680                 685             


Asn Asn Lys Lys Ser Arg Ile Ile Ser Asn Lys Lys Ser Ala Gly Lys 
    690                 695                 700                 


Ser Tyr Asp Val Ile Glu Asp Tyr Asn Ser Ser Asp Asp Val Leu Glu 
705                 710                 715                 720 


Tyr Ile Ser Arg Ile His Lys Ser Glu Met Glu Arg Ile Glu Ile Asn 
                725                 730                 735     


Thr Glu Lys Asn Arg Lys Asp Thr Ser Lys Tyr Ile Arg Asp Phe Ile 
            740                 745                 750         


Glu Glu Val Phe Leu Glu Gly Phe Ile Lys Tyr Leu Asp Asn Asn Asn 
        755                 760                 765             


Leu Asn Phe Leu Lys Asn Arg Asn Lys Val Asp Lys Glu Arg Lys Glu 
    770                 775                 780                 


Ile Ile Arg Asn Leu Asn Ile Lys Ile Glu Gly Leu Asp Ile Leu Asn 
785                 790                 795                 800 


Gln Asn Asp Ser Glu Ile Leu Asn Leu Tyr Leu Phe Phe Asn Met Ile 
                805                 810                 815     


Asp Asn Lys Arg Ile Ser Glu Phe Arg Asn Glu Met Ile Lys Tyr Lys 
            820                 825                 830         


Gln Phe Leu Thr Lys Arg Gln Asn Ile Lys Ser Lys Phe Leu Glu Ile 
        835                 840                 845             


Asp Ile Glu Lys Ile Glu Ala Ile Ile Glu Phe Val Ile Ile Thr Arg 
    850                 855                 860                 


Gly Lys Leu Glu Ile Leu Glu Gly Glu Thr Lys Glu Gln Lys Lys Asp 
865                 870                 875                 880 


Asn Met Asn Ala Leu Phe Asn Lys Phe Tyr Ser Ser Glu Ser Glu Tyr 
                885                 890                 895     


Asp Glu Ser Leu Lys Lys Phe Ile Glu Glu Thr Val Leu Asn Asp Lys 
            900                 905                 910         


Lys Asn Thr Pro Phe Tyr Ser Thr Asp Gly Lys Thr Pro Ile Val His 
        915                 920                 925             


Ser Asn Leu Glu Lys Met Arg Lys Tyr Gly Thr Glu Asn Phe Leu Ser 
    930                 935                 940                 


Lys Val Leu Lys Asp Glu Lys Tyr Thr Leu Glu Asn Met Lys Ile Lys 
945                 950                 955                 960 


Glu Lys Phe Glu Thr Glu Ala Asn Asp Lys Phe Lys Glu Gln Lys Ile 
                965                 970                 975     


Leu Glu Lys Val Asp Lys Ile Lys Gly Asn Glu Lys His Lys Lys Leu 
            980                 985                 990         


Ile Glu Tyr Tyr Asn Asp Cys Arg  Cys Tyr Leu His Lys  Glu Trp Ile 
        995                 1000                 1005             


Glu Asn  Lys Lys Asn Lys Glu  Glu Phe Glu Tyr Lys  Glu Ile Tyr 
    1010                 1015                 1020             


Glu Lys  Ile Ile Glu Glu Ile  Arg Lys Tyr Asn Tyr  Leu Glu Asn 
    1025                 1030                 1035             


Lys Glu  Lys Leu Gln Asn Val  Tyr Leu Leu His Glu  Ile Thr Ser 
    1040                 1045                 1050             


Asp Leu  Met Ala Arg Asn Val  Ala Phe Ile Asn Lys  Trp Glu Arg 
    1055                 1060                 1065             


Asp Phe  Lys Phe Leu Ser Ile  Ala Ile Lys Glu Asn  Leu Lys Asp 
    1070                 1075                 1080             


Ser Asn  Asp Ile Gln Lys Ile  Lys Glu Phe Leu Ala  Pro Ser Leu 
    1085                 1090                 1095             


Asp Thr  Thr Ser Asp Glu Glu  His Phe Asn Val Lys  Asn Tyr Ala 
    1100                 1105                 1110             


Ser Lys  Leu Lys Asn Ile Gln  Gly Leu His Asn Asn  Ile Ile Ser 
    1115                 1120                 1125             


Leu Ile  Phe Ile Lys Asn Leu  Asp Gly Trp Ser Asn  Lys Ile Asp 
    1130                 1135                 1140             


Asn Phe  Lys Trp Leu Gly Phe  Arg Asn Tyr Ile Ser  His Phe Asn 
    1145                 1150                 1155             


His Ile  Asn Gly Glu Asn Ser  Lys Glu Ser Phe Ile  Asn Gln Leu 
    1160                 1165                 1170             


Asn Arg  Leu Ile Leu Leu Phe  Ser Tyr Asp Lys Lys  Val Gln Asn 
    1175                 1180                 1185             


His Ile  Thr Lys Ser Ile Lys  Thr Ile Leu Glu Lys  Tyr Asn Ile 
    1190                 1195                 1200             


Asp Ile  Glu Phe Lys Ile Ser  Asp Asp Ser Lys Asn  Phe Phe Glu 
    1205                 1210                 1215             


Tyr Gln  Ile Ser Asn Ile Asn  Ser Lys Lys Gly Lys  Met Leu Gly 
    1220                 1225                 1230             


Lys Glu  Asn Tyr Phe Glu Leu  Leu Asp Glu Glu Phe  Val Gln Asn 
    1235                 1240                 1245             


Val Lys  Lys Met Leu Glu Tyr  Glu Asp Gln Arg Thr  Gly Gly 
    1250                 1255                 1260         


<210>  672
<211>  1245
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  672

Met Arg Ile Val Arg Pro Tyr Gly Arg Ser Phe Val Asp His Asp Pro 
1               5                   10                  15      


Gly Gly Ala Leu Gln Arg Lys Val Glu Leu Arg Ala Pro Val Ser Ala 
            20                  25                  30          


Glu Gly Gly Pro Arg Gln Leu Asp Leu Gly His Phe Ala Leu Thr His 
        35                  40                  45              


Asp Glu Leu Val Ile Ala Gln Trp Val Ser Cys Ile Asp Lys Ile Ala 
    50                  55                  60                  


Thr Lys Pro Arg Glu Gly Arg Glu Pro Ser Gly Asp Gln Arg Glu Phe 
65                  70                  75                  80  


Arg His His Leu Gly Asn Ala Ala Trp Gly His Leu Glu Thr His Gly 
                85                  90                  95      


Leu Leu Ser Gly Leu Arg Asp Pro Gln Lys Arg Ala Arg Leu Ala Lys 
            100                 105                 110         


Leu Trp Gln Met Lys Ile Ala Pro Tyr Asp Phe Ser Ala Arg Thr Arg 
        115                 120                 125             


Arg Ser Arg Gly Pro Gln Gly Val Asp Ala Pro Ala Lys Gly Arg Trp 
    130                 135                 140                 


Phe Gly Val Phe Ala Gly Asp Val Ser Val Gln Glu Ala Asp Cys Gly 
145                 150                 155                 160 


Ala Ile Val Ala Arg Ile His Glu His Leu Tyr Glu Ser Gln Tyr Arg 
                165                 170                 175     


Leu Gly Glu Glu Thr Pro Leu Arg Ser Ala Gly Leu Ile Ala Arg Arg 
            180                 185                 190         


Ala Gly Ala Ile Thr Thr Ser Val Ala Pro Asp Ala Ala Lys Pro Ser 
        195                 200                 205             


Val Ala Thr Trp Ser Glu Ala Asp Leu Ala Arg Tyr Arg Ser Ala Gly 
    210                 215                 220                 


Asp Val Ala Cys Lys Ile Arg Arg Ala Ala Arg Glu Arg Glu Gln Gly 
225                 230                 235                 240 


Arg Asp Gly Ala Gly Thr Arg Arg Val Thr Asn Ser Val Ala Gly Lys 
                245                 250                 255     


Val Leu Phe Asp His Trp Arg Ala Leu Phe Ser Asp Glu Gly Gly Thr 
            260                 265                 270         


Val Arg Ser Phe Arg Asp Val Glu Gly His Asp Pro Gly Leu Ala Ala 
        275                 280                 285             


Leu His Asn Ala Val Arg Glu Cys Tyr Ala Arg Ile Leu Lys Arg His 
    290                 295                 300                 


Lys Lys Lys Pro Pro Gly Arg Asp Ala Gly Pro Glu Ser Ser Ala Ile 
305                 310                 315                 320 


Leu Arg Ala Leu Pro Arg Asp Met Asp Ala Leu Leu Thr Arg Ile Asp 
                325                 330                 335     


Ser Gly Arg Arg Asn Arg Asp Leu Ala Ala Lys Val Arg Leu Gly Lys 
            340                 345                 350         


Leu Ile His Tyr Thr Ala Ser Asp Pro Ala His Asp Arg Ala Gly Ala 
        355                 360                 365             


Val Ala Glu Arg Trp Pro Gly Asp Val Ala Asp Ser Arg Tyr Arg Thr 
    370                 375                 380                 


Ser Ala Gly Gln Ala Glu Ile Lys Arg Asn Glu Ala Phe Val Arg Val 
385                 390                 395                 400 


Trp Arg His Val Leu Val Leu Ala Ala Arg Thr Leu Glu Asn Trp Ala 
                405                 410                 415     


Asp Pro Glu Asn Arg Ile Asn Arg Asp Ile Leu Ser Ser Gly Gly Ala 
            420                 425                 430         


Lys Ala Ala Cys Glu Gln Phe Glu Ser Ser Arg Phe Met His Lys Cys 
        435                 440                 445             


Asn Val Leu Phe Gly Glu Arg Ala Gly His Phe Ile Gly Gln Asp Asp 
    450                 455                 460                 


Ala Ala Leu Gln Lys Ala Val Leu Glu Leu Ala Leu Glu Arg Leu Gly 
465                 470                 475                 480 


Gln Leu Arg Asn Arg Ser Phe His Phe Thr Gly Arg Gly Gly Phe Leu 
                485                 490                 495     


Glu Val Leu Gln Gln Leu Gly Gln Pro Ala Glu Lys Ala Pro Cys Gln 
            500                 505                 510         


Ser Ala His Asp Arg Thr Met Ala Ser Leu Arg Ala Leu Trp Arg Asp 
        515                 520                 525             


Asp Asp Glu Gly Arg Gly Gly Arg Leu Lys Ala Thr Met Thr Gly Ala 
    530                 535                 540                 


His Phe Glu Thr Phe Leu Asp Glu Ala Gln Ile Arg Arg Phe Phe Asp 
545                 550                 555                 560 


Gln Val Ser Thr Gly Gln Glu Ala Glu Pro Pro Leu Pro Arg Phe Gly 
                565                 570                 575     


Arg Val Leu Gln Arg Ala Lys Asn Thr Arg Asp Ala Gln Ser Asp Leu 
            580                 585                 590         


Arg Pro His Leu Pro Asp Pro Gly Asn Met Arg Thr Leu Glu Asp Pro 
        595                 600                 605             


Ala Arg Leu Cys Gln Tyr Thr Ala Leu Lys Leu Leu Tyr Ala Lys Pro 
    610                 615                 620                 


Phe Arg Thr Trp Leu Ala Glu Ala Asp Ser Ala Val Ile Asn Pro Phe 
625                 630                 635                 640 


Ile Glu Ala Ala Val Thr Arg Ala Arg Arg Glu Ala Gln Lys Ile Trp 
                645                 650                 655     


Ala Ala Arg Thr Gly His His Gly Val Asp Glu Glu Ala Lys Ala Leu 
            660                 665                 670         


Ile Gln Pro Arg Met Ala Met Ile Gly Arg Leu Ala Pro Gly Glu Asn 
        675                 680                 685             


Ile Gln Thr Leu Phe Phe Arg Met Ser Ala Glu Thr Ala Thr Glu Met 
    690                 695                 700                 


Arg Val Gln Ala Gly Tyr Glu Ser Asp Pro Asp Ala Ala Arg Glu Gln 
705                 710                 715                 720 


Ala Glu Phe Ile Glu Asn Leu Lys Cys Asp Val Ile Ala Gln Ala Phe 
                725                 730                 735     


Met Arg Phe Leu Asp Glu Ala Gly Phe Asp Phe Leu Leu Thr Leu Asp 
            740                 745                 750         


Ala Arg Ala Ala Arg Pro Glu Ser Ala Arg Phe Asp Leu Ala Met Leu 
        755                 760                 765             


Asp Ala Ala Ala Arg Ala Glu Glu Pro Gln Asp Trp Met Leu Val Leu 
    770                 775                 780                 


Tyr Phe Leu Leu His Leu Val Pro Val Asp Glu Ala Gly Arg Leu Leu 
785                 790                 795                 800 


His Gln Leu Arg Lys Trp Glu Ile Leu Ala Gly Pro Glu Glu Ala Gly 
                805                 810                 815     


Ala Arg Thr Gly Ala Asp Ala Ala Asn Ser Thr Leu Ser Gly Leu Tyr 
            820                 825                 830         


Gln Val Leu Asp Leu Tyr Leu Asp Met His Asp Ala Lys Phe Ser Gly 
        835                 840                 845             


Gly Ala Ala Leu Tyr Gly Ala Arg His Phe Arg Asn Leu Phe Glu Asp 
    850                 855                 860                 


Glu Ala Asp Phe Asp Arg Leu Phe Pro Val Ala Asp Ala Gly Glu Glu 
865                 870                 875                 880 


Asp Lys Arg Ile Pro Leu Arg Gly Leu Arg Glu Ile Leu Arg Phe Gly 
                885                 890                 895     


Asp Arg Ala Thr Leu Glu Ala Ile Tyr Ala Gln Asn Arg Ile Arg Pro 
            900                 905                 910         


Ala Glu Val Ala Glu Val Leu Asp Leu Glu Ala Pro Asp Ala Asp Gly 
        915                 920                 925             


Met Ser Arg Ile Ala Gly His His Ala Arg Arg Glu Lys Leu His Ala 
    930                 935                 940                 


Gln Trp Val Glu Ala Lys Gln Ser Phe Asp Asp Asp Ala Val Arg Asp 
945                 950                 955                 960 


Tyr Phe Val Ala Leu Gly Gln Val Val Arg His Arg His Leu Ala Ala 
                965                 970                 975     


Arg Ala Arg Leu Val Asp His Val Arg Leu His Arg Leu Met Met Asn 
            980                 985                 990         


Val Leu Gly Arg Leu Ala Asp Phe  Ala Gly Leu Trp Glu  Arg Asp Val 
        995                 1000                 1005             


Tyr Phe  Val Met Leu Ala Thr  Leu Tyr Glu Gln Gly  Thr Ser Pro 
    1010                 1015                 1020             


Ala Ala  Val Leu Asn Cys Glu  Ala Arg Arg Lys Leu  Ser Gln Gly 
    1025                 1030                 1035             


Arg Ile  Val Glu Val Ile Arg  Ala Leu Lys Pro Val  Asp Gly Gly 
    1040                 1045                 1050             


Ala Leu  Tyr Ala Ala Ile Thr  Gly His Phe Pro Gly  Phe Asp Thr 
    1055                 1060                 1065             


Arg Arg  Asn Asp Asp Pro Val  Gln Leu Arg Asn Asn  Phe Ala His 
    1070                 1075                 1080             


Phe Asn  Met Leu Arg Gln Gly  His Met Pro Asp Leu  Thr Ala Cys 
    1085                 1090                 1095             


Val Asn  Arg Ala Arg Arg Leu  Met Ala Tyr Asp Arg  Lys Leu Lys 
    1100                 1105                 1110             


Asn Ala  Val Ser Lys Ala Val  Ile Glu Leu Leu Ala  Arg Glu Gly 
    1115                 1120                 1125             


Leu Thr  Leu Ser Trp Arg Met  Asp Ala Arg Gly Pro  Gln His Asp 
    1130                 1135                 1140             


Leu Thr  Glu Ala Arg Ile Thr  Ala Arg Thr Ala Thr  His Leu Gly 
    1145                 1150                 1155             


Gly Ile  Arg Leu Thr Gln Arg  Gly Gly Ser Thr Gly  Ser Arg Pro 
    1160                 1165                 1170             


Phe Pro  Leu Thr Glu Ala Leu  His Gly Thr Gly Phe  Ala Arg Met 
    1175                 1180                 1185             


Val Ala  Gln Leu Phe Ala Gly  Gln Asp Arg Pro Ser  Arg Cys Val 
    1190                 1195                 1200             


Ser Gln  Asp Asp Pro Thr Thr  Ile Glu Arg Ala Pro  Ala Arg Asn 
    1205                 1210                 1215             


Thr Asn  Arg Lys Glu Ser Ala  Lys Lys Arg Met Lys  Pro Gly Arg 
    1220                 1225                 1230             


Asp Gly  Gly Arg Arg His Glu  Lys Ser Arg Arg Gly  
    1235                 1240                 1245 


<210>  673
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  673

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Ile Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Phe Asp Phe Lys Leu  Leu Asn 
    1400                 1405                 1410         


<210>  674
<211>  1358
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  674

Met Lys Ile Ser Lys Glu Gly His Lys Arg Met Ser Val Thr Leu Lys 
1               5                   10                  15      


Lys Glu Asn Met Gln Lys Asn Asp Ala Asp Lys Thr Lys Gly Gln Ile 
            20                  25                  30          


Leu Pro Leu Pro Glu Gly Glu Gly Leu Glu Lys Tyr Ile Gln Lys Arg 
        35                  40                  45              


Val Ala Asn Thr Gln Lys Leu Tyr Lys Val Leu Gly Pro Ser Ala Val 
    50                  55                  60                  


Ser Val Pro Asn Glu Lys Glu Lys Glu Thr Ile Asp Cys Phe Asn Asp 
65                  70                  75                  80  


Phe Ile Lys Asn Ile Ile Leu Lys Asn Val Asn Thr Gln Pro Ala Glu 
                85                  90                  95      


Lys Arg Asn Arg Asn Ala Val Glu Tyr Met Lys Thr Lys Gly Asn Val 
            100                 105                 110         


Asn Thr Val Phe Ile Asp Val Asp Arg Lys Cys Ile His Lys Leu Val 
        115                 120                 125             


Pro Leu His Leu Arg Gly Thr Leu Lys Lys Tyr Val Lys Ile Glu Lys 
    130                 135                 140                 


Asp Gly Gln Arg Ile Glu Val Tyr Ile Pro Asp Val Ile Glu Lys Leu 
145                 150                 155                 160 


Val Phe Ala Val Ala His Gly Thr Gln Phe Asp His Leu Ile Ala Glu 
                165                 170                 175     


Ile Glu Glu Glu Glu Leu Ile Val Cys Leu His Met Ile Phe Lys Asp 
            180                 185                 190         


Tyr Thr Lys Glu Asp Ile Ile Ala Asn Thr Ala Lys Ser Ile Glu Lys 
        195                 200                 205             


Gln Asp Val Lys Val Gln Val Leu Gly Thr Gly Glu Asp Ala Arg Leu 
    210                 215                 220                 


Gln Leu Ala Ser Ala Asp Asn Glu Lys Lys Lys Tyr Ile Phe Leu Phe 
225                 230                 235                 240 


Leu Lys Lys Phe Ala Cys Ala Val Ser Glu Lys Glu Arg Asn Asp Leu 
                245                 250                 255     


Leu Arg Glu Phe Arg Glu Leu Leu Val Leu Phe Tyr Cys Gly Thr Ala 
            260                 265                 270         


Ala Tyr Glu Glu Val Lys Glu Trp Lys Asn Gly Ile Pro Ile Trp Asp 
        275                 280                 285             


Phe Asp Phe Leu Ser Lys Met Val Ser Asp Ile Ser Trp Phe Phe Ser 
    290                 295                 300                 


Gln Glu Cys Ser Glu Lys Leu Met Glu Arg Glu Gln Leu Arg Arg Glu 
305                 310                 315                 320 


Lys Asp Lys Asp Lys Lys Arg Gln Asn Lys Ser Lys Ile Lys Asp Ile 
                325                 330                 335     


Asp Val Glu Val Lys Gly Ile Leu Ala Asn Leu Ile Thr Glu Arg Tyr 
            340                 345                 350         


Arg Glu Ser Ile Lys Leu Leu Gln Ser Leu Leu Gly Glu Glu Glu Tyr 
        355                 360                 365             


Lys Glu Lys Cys Phe Trp Leu Glu Tyr Ile Glu Asn Asp Ala Glu Lys 
    370                 375                 380                 


Ile Leu Cys Ser Lys Lys Ala Leu Thr Glu Asn Lys Leu Asp Thr Val 
385                 390                 395                 400 


Trp Leu Cys Asn Asn Thr Trp Arg Asn Phe Leu Ser Phe Leu Cys Ser 
                405                 410                 415     


Lys Ala Val Asp Met Gly Lys Ala Val Tyr His Phe Ala Met Pro Asp 
            420                 425                 430         


Leu Glu Gln Leu Glu Ser Gly Glu Pro Ile Lys Ala Gly Met Ile Lys 
        435                 440                 445             


Pro Gln Phe Gln Gln Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys 
    450                 455                 460                 


Ala Glu Glu Asn Leu Glu Arg Ser Phe Met Thr Ala Ile Ser Phe Ala 
465                 470                 475                 480 


Leu Asn Asn Phe Ser Ala Ala Val Cys Pro Pro Glu Asn Tyr Glu Lys 
                485                 490                 495     


Lys Asn Lys Glu Asp Val Leu Phe Met Gly Asp Lys Asp Leu Arg Glu 
            500                 505                 510         


Glu Met Tyr Pro Asn Ala Ser Trp His Ile Met Gln Tyr Phe Gly Gly 
        515                 520                 525             


Ile Ser Gln Trp Lys Asp Ser Cys Phe Glu Asp Ile Val Met Leu Glu 
    530                 535                 540                 


Asp Ala Asp Leu Asn Glu Glu Phe Val Leu Glu Val Lys Gly Ala Met 
545                 550                 555                 560 


Ser Leu Ile Arg Asn Ser Ala Phe His Tyr Ala Ala Ser Ala Ala Gln 
                565                 570                 575     


Gly Thr Leu Asp Lys Gly Ser Tyr Leu Val Glu Leu Phe Glu Arg Glu 
            580                 585                 590         


Arg Asp Asn Leu Gly Ser Lys Tyr Arg Lys Lys Tyr Val Ser Asn Asn 
        595                 600                 605             


Val Pro Met Phe Tyr Lys Val Glu Asp Ile Asp Arg Leu Met His Cys 
    610                 615                 620                 


Leu Tyr Gly Glu Gln Lys Val Leu Glu Ser Gln Ile Pro Ser Phe Arg 
625                 630                 635                 640 


Asn Val Ile Thr Arg Lys Ser Leu Pro Asp Ile Ile Val Lys Phe Val 
                645                 650                 655     


Lys Gly Lys Pro Tyr Gly Lys Ile Gln Lys Asn Val Glu Thr Ala Ser 
            660                 665                 670         


Lys Phe His Ser Ala Leu Tyr Phe Val Leu Lys Glu Ile Tyr Tyr Asn 
        675                 680                 685             


Gly Phe Leu Gln Glu Glu Asn Leu Met Glu Arg Phe Met Val Ser Phe 
    690                 695                 700                 


Asn Asn Glu Trp Asn Lys Val Lys Glu Ser Ser Gly Asn Lys Lys Lys 
705                 710                 715                 720 


Glu Ala Ala Met Lys Asp Phe Ser Arg Arg Ile Ser Glu Leu Gln Gln 
                725                 730                 735     


Asn Gly Lys Arg Leu Thr Phe Gly Glu Leu Cys Gln Ala Ile Met Thr 
            740                 745                 750         


Asp Tyr Asn Met Gln Asn Asn Gln Lys Lys Val Arg Leu Asn Lys Lys 
        755                 760                 765             


Asp Asn Leu Pro Asp Glu Lys Tyr Lys His Phe Lys Met Leu Leu Leu 
    770                 775                 780                 


Val Cys Leu Arg Glu Thr Phe Ile Asp Tyr Leu Lys Lys Asp Val Ala 
785                 790                 795                 800 


Gly Glu Lys Phe Asp Cys Ala Phe Leu Arg Glu Pro Gly Leu Lys Glu 
                805                 810                 815     


Asn Val Tyr Glu Asn Leu Thr Glu Glu Gln Phe Cys Lys Gly Trp Lys 
            820                 825                 830         


Ile Asp Arg Tyr Lys Asn Leu Ile Asn Glu Asn Gly Gln Tyr Asp Ser 
        835                 840                 845             


Trp Leu Ile Ser Trp Phe Ile Leu Ala His Phe Met Thr Pro Lys His 
    850                 855                 860                 


Leu Asn His Leu Cys Gly Glu Ile Lys Ser Tyr Leu Ser Tyr Val His 
865                 870                 875                 880 


Asn Ile Glu Arg Arg Arg Phe Asp Ala Met Arg Val Gln Val Glu Glu 
                885                 890                 895     


Asn Lys Glu Lys Arg Gln Lys Tyr Glu Gln Val Leu Glu Ile Leu Asn 
            900                 905                 910         


Leu Ala Ala Glu Tyr Cys Gly Gln Val Ser Asn Glu Arg Thr Asp Tyr 
        915                 920                 925             


Tyr Glu Ser Glu Glu Glu Tyr Ala Arg His Ile Ser Met Tyr Val Ala 
    930                 935                 940                 


Phe Glu Glu Lys Asn Ser Glu Arg Pro Leu Glu Glu Gln Leu Tyr Gly 
945                 950                 955                 960 


Phe Cys Asn Gln Lys Ala Asp Gly Gly Pro Ala Ser Arg Ile Gly Ile 
                965                 970                 975     


Phe Tyr Asp Gly Glu Asn Pro Ile Leu Asn Arg Asn Val Val Leu Thr 
            980                 985                 990         


Lys Leu Tyr Gly Ala Glu Arg Leu  Leu Ser Glu Cys Leu  Gln Lys Glu 
        995                 1000                 1005             


Arg Val  Thr Lys Ala Glu Ile  Glu Lys His Tyr Lys  His Thr Lys 
    1010                 1015                 1020             


Lys Leu  Glu Ala Val Phe Lys  Tyr Gly Thr Cys Lys  Asn Gln Glu 
    1025                 1030                 1035             


Gln Glu  Gln Glu Arg Arg Thr  Tyr Gln Gln Gln Lys  Asn Arg Ile 
    1040                 1045                 1050             


Glu Leu  Val Asp Ile Leu Lys  Tyr Ser Asp Leu Leu  Asn Asp Phe 
    1055                 1060                 1065             


Met Ser  Gln Leu Ile Ser Trp  Cys Tyr Leu Arg Glu  Arg Asp Arg 
    1070                 1075                 1080             


Met Tyr  Phe Gln Ile Gly Leu  His Tyr Ile Arg Leu  Tyr Tyr Gly 
    1085                 1090                 1095             


Glu Asn  Leu Val Glu Lys Asn  Ser Lys Phe Arg Val  Leu Gln Ser 
    1100                 1105                 1110             


Lys Glu  Ala Lys Ala Gly Glu  Lys Lys Gly Ile Asn  Leu Val Asp 
    1115                 1120                 1125             


Gly Ala  Val Leu Tyr Gln Ile  Ala Ala Ile Tyr Thr  Tyr Glu Tyr 
    1130                 1135                 1140             


Pro Val  Tyr Ala Leu Asp Glu  Ala Gly Asn Ala Ile  Val Ser Lys 
    1145                 1150                 1155             


Ala Ala  Lys Ile Gly Ser Thr  Thr Ala Asn Gly Ile  Asn Ala Phe 
    1160                 1165                 1170             


Trp Lys  Glu Tyr Cys Asn Glu  Asp Ala Ser Thr Tyr  Glu Val Gly 
    1175                 1180                 1185             


Leu Ser  Leu Phe Glu Asn Pro  Leu Glu Glu Lys Glu  Leu Ile Glu 
    1190                 1195                 1200             


Phe Arg  Asn Tyr Ile Asp His  Phe Lys Tyr Tyr Ser  Arg Arg Asp 
    1205                 1210                 1215             


Arg Ser  Ile Leu Asn Leu Tyr  Ser Gln Val Phe Ala  Asn Tyr Phe 
    1220                 1225                 1230             


Arg His  Asp Arg Lys Leu Lys  Lys Ser Val Thr Phe  Ile Leu Lys 
    1235                 1240                 1245             


Asn Ile  Leu Ala Arg His Phe  Ile Ile Ala Arg Thr  Val Leu Ala 
    1250                 1255                 1260             


Glu Val  Glu Val Glu Lys Lys  Asp Gly Arg Lys Asp  Lys Lys Asn 
    1265                 1270                 1275             


Pro Ile  Ile Arg Lys Tyr Ser  Gln Thr Glu Ile Arg  Ile Pro Thr 
    1280                 1285                 1290             


Glu Asn  Gly Leu Gln Ser Asp  Asp Thr Leu His Lys  Tyr Thr Lys 
    1295                 1300                 1305             


Glu Asp  Val Asp Asn Glu Tyr  Lys Lys Lys Met Asn  Asn Ser Lys 
    1310                 1315                 1320             


Gly Glu  Lys Gly Lys Ile Pro  Pro Lys Glu Gly Gly  Lys Tyr Ser 
    1325                 1330                 1335             


Ile Pro  Met Tyr Asp Glu Lys  Phe Ile Gln Arg Leu  Tyr Cys Ile 
    1340                 1345                 1350             


Leu Asn  Tyr Ala Lys 
    1355             


<210>  675
<211>  1344
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  675

Met Lys Ile Ser Lys Glu Ser His Arg Lys Thr Gly Val Leu Ile Asn 
1               5                   10                  15      


Asn Ser Gly Ala Glu Gly Ile Leu Tyr Lys Asp Pro Leu Lys Ser Asn 
            20                  25                  30          


Glu Lys Ile Glu Asp Val Val Asn Ala Arg Ala Asn Ser Thr Lys Arg 
        35                  40                  45              


Leu Phe Asn Leu Phe Gly Thr Gly Glu Glu Ser Lys Asp Ile Ser Lys 
    50                  55                  60                  


Asn Ala Lys Glu Val Ala Lys Thr Val Asn Arg Ala Ile Gly Asn Leu 
65                  70                  75                  80  


Lys Ala Asn Lys Lys Phe Asn Lys Lys Glu Arg Ile Asn Ser Glu Leu 
                85                  90                  95      


Lys Val Asp Val Leu Ile Glu Glu Leu Lys Lys Cys Arg Asn Ser Phe 
            100                 105                 110         


Ser Ala Asp Glu Val Asn Glu Ala Leu Asp Arg Leu Leu Lys Lys Ser 
        115                 120                 125             


Phe Arg Val Ala Pro Tyr Lys Asp Ala Val Arg Leu Leu Leu Met Ser 
    130                 135                 140                 


Thr Leu Val Asn Lys Lys Ala Leu Ser Asn Glu Glu Lys Asp Lys Val 
145                 150                 155                 160 


Gln Asn Tyr Phe Ile Lys Lys Leu Val Ala Glu Tyr Asp Lys Thr Leu 
                165                 170                 175     


Ile Lys Lys Gln Ile Pro Lys Ala Leu Val Asn Gln Asn Met Val Ile 
            180                 185                 190         


Gln Pro Ser Ser Asn Asp Gly Thr Leu Val Ile Ala Glu Thr Asn Lys 
        195                 200                 205             


Ser Lys Glu Thr Lys Leu Thr Glu Lys Asp Ala Phe Arg Leu Phe Leu 
    210                 215                 220                 


Arg Asp Tyr Ala Thr Leu Asp Asp Lys Leu Arg His Glu Met Arg Leu 
225                 230                 235                 240 


Lys Leu Arg Arg Leu Val Asp Leu Tyr Phe Tyr Gly Glu Glu Ala Val 
                245                 250                 255     


Ile Lys Glu Asp Phe Asp Glu Trp Glu Ile His Glu Lys Arg Lys Ala 
            260                 265                 270         


Asp Thr Ala Leu Phe Val Asp Lys Ala Thr Lys Ile Lys Ala Leu Lys 
        275                 280                 285             


Asn Gly Val Lys Arg Glu Ile Leu Asp Val Asp Thr Thr Leu Asp Ala 
    290                 295                 300                 


Ile Arg Gly Lys Asn Ile Ser Cys Tyr Arg Lys Ser Val Ser Ile Val 
305                 310                 315                 320 


Lys Asn Asn Asn Thr Gly Tyr Phe Asp Ser Glu Ala Leu Asn Lys Phe 
                325                 330                 335     


Trp Ile His His Ile Glu Asn Glu Val Glu Arg Ile Tyr Gly His Leu 
            340                 345                 350         


Lys Asn Asp Thr Gly Asn Tyr Lys Phe Gln Leu Gly Tyr Leu Ser Glu 
        355                 360                 365             


Lys Val Trp Lys Gly Ile Ile Asn Tyr Leu Ser Ile Lys Tyr Ile Ala 
    370                 375                 380                 


Glu Gly Lys Ala Val Tyr His Tyr Ala Met Lys Ala Leu Ser Ser Asp 
385                 390                 395                 400 


Asp Thr Thr Lys Thr Phe Gly Lys Val Asp Glu Lys Tyr Leu Lys Gly 
                405                 410                 415     


Ile Ser Ser Phe Glu Tyr Glu Arg Ile Lys Ala Glu Glu Thr Leu Gln 
            420                 425                 430         


Arg Glu Cys Ala Val Asn Val Ala Phe Ala Ala Asn His Leu Ala Asn 
        435                 440                 445             


Ala Thr Val Gln Leu Asp Glu Asn Asn Thr Asp Phe Leu Leu Leu Lys 
    450                 455                 460                 


Asn Lys Glu Pro Gln Glu Asp Ser Lys Lys Lys Gly Thr Lys Ser Leu 
465                 470                 475                 480 


Ala Glu Cys Ala Ser Ala Lys Pro Asn Thr Leu Arg Asn Ile Leu Gln 
                485                 490                 495     


Phe Phe Gly Gly Lys Ser Thr Trp Glu Asp Phe Asp Phe Ser Gly Tyr 
            500                 505                 510         


Asp Glu Ile Glu Leu Leu Asn Asp Met Lys Glu Met Ile Tyr Ser Leu 
        515                 520                 525             


Arg Asn Met Ser Phe His Phe Lys Thr Glu Asn Val Asn Glu Gly Lys 
    530                 535                 540                 


Trp Asn Thr Glu Leu Ile Gly Arg Met Phe Ala His Asp Cys Asp Arg 
545                 550                 555                 560 


Ala Ser Ile Val Gln Lys Asn Lys Leu Tyr Ser Asn Asn Ala Ala Met 
                565                 570                 575     


Phe Tyr Asn Ser Ser Asp Leu Ala Lys Leu Leu Asp Lys Leu Tyr Asn 
            580                 585                 590         


His Tyr Asn Glu Arg Ala Ser Gln Val Pro Ser Phe Asn Thr Val Phe 
        595                 600                 605             


Val Arg Lys Asn Phe Pro Glu Tyr Leu Lys Gln Gln Gln Ile Thr Pro 
    610                 615                 620                 


Ala Leu Ser Ala Glu Asp Thr Leu Lys Trp Gln Ser Thr Val Tyr Tyr 
625                 630                 635                 640 


Leu Tyr Lys Glu Ile Tyr Tyr Asn Ala Phe Leu Gln Asp Lys Glu Ser 
                645                 650                 655     


Phe Asn Leu Leu Lys Gln Tyr Val Arg Asn Leu Asp Glu His Cys Gln 
            660                 665                 670         


Asp Lys Asn Gln Ala Gly Ala Asn Arg Asp Phe Lys Ala Ala Phe Glu 
        675                 680                 685             


Ile Tyr Ser Glu Ser Gly Ser Met Ser Ala Thr Cys Gln Met Ile Met 
    690                 695                 700                 


Thr Glu Tyr Asn Asn Gln Asn Lys Gly Asn Arg Val Gly Ile Ser Gly 
705                 710                 715                 720 


Arg Thr Asn Ser Asp Asp Lys Leu Ile Phe Gln His Tyr Lys Met Ile 
                725                 730                 735     


Leu Phe Asp Gly Leu Lys Ala Ala Phe Phe Glu Tyr Leu Lys Lys Asn 
            740                 745                 750         


Gly Glu Val Tyr Asp Phe Ile Lys Thr Pro Lys Leu Val Thr Ile Leu 
        755                 760                 765             


Val Asp Ala Asp Val Phe Leu Gly Asp Tyr Lys Ser His Gln Tyr Asp 
    770                 775                 780                 


Ser Leu Val Glu Asn Val Lys Thr Asn Pro Glu Leu Gln Lys Trp Tyr 
785                 790                 795                 800 


Ile Thr Gly Arg Leu Leu Asn Pro Lys Gln Val Asn Gln Leu Ile Gly 
                805                 810                 815     


Thr Phe Arg Ser Tyr Val Gln Tyr Val Asn Asp Val Met Arg Arg Ala 
            820                 825                 830         


Lys Gln Val Lys Asn Pro Leu Thr Asp Glu Thr Ile Ser Ile Asp Val 
        835                 840                 845             


Asp Asn Ile Ile Lys Val Leu Asp Ile Cys Thr Lys Leu Asn Gly Ala 
    850                 855                 860                 


Thr Ser Asn Lys Ile Asp Asp Tyr Phe Asp Asn Gly Asp Glu Tyr Ala 
865                 870                 875                 880 


Lys Tyr Leu Gly Lys Phe Val Asp Phe Gly Leu Arg Asp Asp Val Asn 
                885                 890                 895     


Leu Ala Asn Ala Lys Leu Ala Gly Phe Cys Asp Gln Glu Val Asp Gly 
            900                 905                 910         


Gln Lys Ile Gly Ile Tyr His Asp Gly Thr Asn Pro Ile Leu Asn Arg 
        915                 920                 925             


Asn Val Val Leu Cys Lys Leu Tyr Gly Ala Ser Asp Val Val Ala Gln 
    930                 935                 940                 


Ala Gly Ile Leu Pro Val Asp Phe Glu Ile Ile Lys Lys Tyr Met Gln 
945                 950                 955                 960 


Leu Ser Gly Asn Ile Lys Glu Tyr Gln Leu Thr Gly Thr Cys Lys Thr 
                965                 970                 975     


Lys Ala Asp Gln Leu Lys Leu Lys Lys Tyr Gln Glu Leu Lys Asn Met 
            980                 985                 990         


Val Glu Leu Arg Asn Ile Val Asp  Tyr Ser Glu Leu Val  Asp Glu Leu 
        995                 1000                 1005             


Gln Gly  Gln Leu Ile Asn Trp  Gly Tyr Leu Arg Glu  Arg Asp Leu 
    1010                 1015                 1020             


Met Tyr  Phe Gln Leu Gly Phe  Asn Tyr Leu Ala Leu  Asn Asn Asp 
    1025                 1030                 1035             


Thr Gln  Lys Pro Glu Gly Tyr  Glu Lys Ala Gly Asp  Ile Asn Gly 
    1040                 1045                 1050             


Ala Ile  Leu Tyr Gln Ile Val  Ala Met Tyr Thr Asn  Gly Leu Ser 
    1055                 1060                 1065             


Leu Ile  Asp Ala Thr Gly Lys  Ser Lys Gly Asn Ala  Lys Ala Ser 
    1070                 1075                 1080             


Ala Gly  Ala Lys Ile Gly Ser  Phe Cys Ser Tyr Ser  Lys Ser Leu 
    1085                 1090                 1095             


Arg Asn  Val Pro Gly Asp Thr  Lys Glu Glu Ile Asp  Pro Ile Tyr 
    1100                 1105                 1110             


His Ala  Gly Leu Glu Leu Phe  Glu Asn Ile Asn Glu  His Asp Gln 
    1115                 1120                 1125             


Cys Val  Ala Leu Arg Asn Tyr  Ile Glu His Phe His  Tyr Tyr Ala 
    1130                 1135                 1140             


Lys Met  Asp Arg Ser Leu Leu  Asp Ile Tyr Ser Glu  Val Phe Asp 
    1145                 1150                 1155             


Arg Phe  Phe Thr Tyr Asp Met  Lys Tyr Ala Lys Asn  Val Pro Asn 
    1160                 1165                 1170             


Met Leu  Tyr Asn Ile Leu Leu  Gln His Leu Val Val  Pro Ser Phe 
    1175                 1180                 1185             


Glu Phe  Asn Ser Gly Glu Lys  Lys Leu Gly Asp His  Asn Ser Leu 
    1190                 1195                 1200             


Ser Lys  Lys Arg Ala Thr Ile  Ser Leu Lys Ser Glu  Asn Gly Leu 
    1205                 1210                 1215             


Ala Ser  Glu Lys Phe Thr Tyr  Lys Ile Gly Asp Lys  Lys Asn Pro 
    1220                 1225                 1230             


Ile Lys  Leu Ser Ala Arg Ser  Asn Asp Tyr Leu Ser  Asp Val Ala 
    1235                 1240                 1245             


Ala Ile  Leu Tyr Tyr Pro Asp  Lys Ala Pro Thr Gly  Val Val Arg 
    1250                 1255                 1260             


Asp Thr  Val Lys Glu Asp Asn  Ser Ala Lys Glu Gln  Gly Lys Lys 
    1265                 1270                 1275             


Ser Lys  Asp Phe Ala Gly Pro  Arg Asn Asn Lys Asn  Asn Asn Tyr 
    1280                 1285                 1290             


His Gly  His Asn Asn Gly Tyr  Asn Asn Gln Lys Arg  Asp Tyr Ser 
    1295                 1300                 1305             


Lys Gln  Asn Glu Asn Glu Tyr  Ser Gly Ser Leu Ser  Thr Gly Leu 
    1310                 1315                 1320             


Phe Asp  Ala Ala Asn Tyr Lys  Lys Asp Arg His Asn  Asn Asn Gln 
    1325                 1330                 1335             


Asn Tyr  Lys Lys Arg Lys 
    1340                 


<210>  676
<211>  1425
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  676

Met Lys Phe Thr Lys Val Lys Asn Ser Arg Val Ala Val Gly Phe Glu 
1               5                   10                  15      


His Glu Lys Asn Arg Gly His Arg Gly Met Met Tyr Lys Glu Pro Ala 
            20                  25                  30          


Val Asn Asn Glu Cys Val Leu Asn Val Asp Lys His Ile Glu Glu Arg 
        35                  40                  45              


Tyr Lys Asp Ala Gly Lys Leu Tyr Thr Val Leu Asn Gln Asn Val Val 
    50                  55                  60                  


Ile Phe Asp Gly Lys Asp Lys Ile Met Val Lys Lys Gln Lys Ile Cys 
65                  70                  75                  80  


Lys Glu Ala Val Lys Ile Phe Cys Ser Asn Cys Ser Lys Phe Lys Asn 
                85                  90                  95      


Asn Arg Asn Glu Phe Ile Glu Lys Ile Lys Leu Cys Gly Val Ala Lys 
            100                 105                 110         


Ile Ile Asn Asp Leu Asn Ile Asn Glu Asn Val Asn Phe Asp Glu Gly 
        115                 120                 125             


Leu Glu Ser Leu Ser Arg Leu Ile Ile Glu Lys Thr Leu Arg Lys Ser 
    130                 135                 140                 


Leu Asn Lys Lys Ile Ser Trp Pro Met Asp Gly Asp Lys Val Glu Thr 
145                 150                 155                 160 


Tyr Asn Leu Ala Asp Ile Ala Ala Lys Leu Leu Tyr Tyr Met Val Leu 
                165                 170                 175     


Asn Asn Arg Tyr Tyr Lys Asn Lys Lys Asp Asp Trp Lys Asn Gly Asn 
            180                 185                 190         


Gly Pro Val Thr Asp Asp Glu Leu Met Ala Phe Phe Gly Tyr Ile Asp 
        195                 200                 205             


Ser Asp Lys Lys Gly Lys Val Lys Lys Ala Gly Ser Asn Ile Thr Arg 
    210                 215                 220                 


Ala Lys Met Ile Ala Glu Ser Ile Lys Arg Lys Asp Val Lys Val Gln 
225                 230                 235                 240 


Leu Thr Lys Lys Asp Glu Thr Tyr Arg Leu Met Leu Ser Asn Ala Glu 
                245                 250                 255     


His Pro Lys Lys Arg Phe Val Val Asp Phe Ile Lys Arg Tyr Ala Asn 
            260                 265                 270         


Leu Glu Arg Thr Ala Gln Val Glu Glu Leu Leu His Ile Lys Lys Leu 
        275                 280                 285             


Met Val Met Phe Val Tyr Gly Glu Lys Glu Pro Glu Phe Tyr Asn Lys 
    290                 295                 300                 


Glu Asn Pro Tyr Lys Arg Leu Asp Glu Thr Asp Glu Arg Ile Phe Cys 
305                 310                 315                 320 


Glu Asp Ala Lys Asn Ile Leu Glu Gln Ile Glu Gln Asn Ser Asn Asn 
                325                 330                 335     


Gly Lys Trp Lys Asp Asn Lys Lys Leu His Ile Gln Leu Gly Glu Ser 
            340                 345                 350         


Phe Arg Lys Glu Leu Phe Lys Arg Tyr Lys Gln Met Glu Asp Trp Leu 
        355                 360                 365             


Ser Glu Gln Tyr Lys Val Glu Lys Asp Gly Leu Ile Ala Asn Lys Gly 
    370                 375                 380                 


Tyr Asp Leu Thr Asn Lys Asn Leu Met Arg Ala Lys Glu Asp Leu Tyr 
385                 390                 395                 400 


Trp Ile Ile Ile Phe Glu Glu Asn Ile Glu Ser Tyr Phe Lys Arg Trp 
                405                 410                 415     


Asn Lys Arg Ser Leu Lys Asn Cys Arg Cys Ser Trp Ile Val Asn Arg 
            420                 425                 430         


Leu Trp Asn Glu Trp Asn Ser Leu Ile Cys Met Lys Tyr Ile Asp Leu 
        435                 440                 445             


Gly Lys Ala Val Phe Asn Phe Ala Met Pro Asp Leu His Asp Leu Ser 
    450                 455                 460                 


Asp Gly Glu Ile Lys Leu Gly Thr Val Leu Pro Glu Tyr Gln Glu Gly 
465                 470                 475                 480 


Ile Thr Ser Phe Asp Tyr Glu Met Val Lys Ala Lys Glu Asn Ile Thr 
                485                 490                 495     


Arg Asp Ile Ala Thr Ser Ile Val Phe Ala Ala Asn Thr Phe Ser Asn 
            500                 505                 510         


Ala Val Ile Lys Arg Glu Tyr Arg Glu Gln Pro Asp Lys Asn Ile Arg 
        515                 520                 525             


Asn Asp Val Leu Val Tyr Asp Glu Glu Val Phe Gln Asn Arg Glu Ala 
    530                 535                 540                 


Val Gln Glu Asn Ala Phe Lys His Ile Phe Gln Tyr Phe Gly Gly Ala 
545                 550                 555                 560 


Ser Thr Trp His Gly Leu Asp Phe Leu Phe Ala Gln Thr Ser Gly Val 
                565                 570                 575     


Asp Thr Glu Lys Asn Thr Tyr Val Ile Glu Gly Lys Asp Pro Val Thr 
            580                 585                 590         


Gln Glu Lys Phe Lys Lys Asn Phe Ala Phe Ala Ile Lys Gln Cys Ile 
        595                 600                 605             


Ala Ala Leu Arg Asn Asn Ser Phe His Tyr Thr Thr Asp Arg Lys Phe 
    610                 615                 620                 


Val Ala Asp Asp Asn Ile Leu Ile Glu Lys Gln Ile Ala Asp Tyr Leu 
625                 630                 635                 640 


Phe Lys Glu Glu Tyr Ser Arg Leu Pro Lys Met Phe Ala Glu Lys Tyr 
                645                 650                 655     


Phe Ser Asn Asn Val Pro Leu Phe Phe Asp Asn Glu Asp Ile Phe Lys 
            660                 665                 670         


Leu Ala Asn Tyr Leu Tyr Cys Gly Glu Ser Val Arg Glu Ala Gln Val 
        675                 680                 685             


Pro Ala Phe Ala Ser Val Ile Lys Arg Lys Tyr Ile Asp Glu Phe Leu 
    690                 695                 700                 


Phe Thr Ser Asp Ala Glu Glu Lys Pro Phe Ile Ser Met Glu Gln Glu 
705                 710                 715                 720 


Glu Ile Lys Lys Ile Tyr Thr Asn Glu Asp Ile Arg Asn Ile Phe Phe 
                725                 730                 735     


Ser Ala Met Tyr Phe Ile Leu Lys Glu Ile Tyr Tyr Tyr Gly Phe Leu 
            740                 745                 750         


Lys Ser Lys Asp Leu Met Glu Arg Phe Ser Lys Ala Phe Glu Gln Tyr 
        755                 760                 765             


Tyr Gln Asn Met Met Asn Asn Lys Arg Asn Lys Glu Tyr Phe Ala Val 
    770                 775                 780                 


Asp Asn Phe Lys Lys His Leu Asp Glu Leu Lys Asn Lys Asn Lys Asn 
785                 790                 795                 800 


Ile Thr Phe Gly Glu Phe Cys Gln Gln Ile Met Thr Asp Tyr Asn Met 
                805                 810                 815     


Gln Asn Gln Asp Leu Lys Asp Val Met Thr Ile Asn Lys Glu Asn Glu 
            820                 825                 830         


Leu Lys Arg Lys Gly Glu Lys Glu Lys Tyr Lys His Tyr Val Leu Ile 
        835                 840                 845             


Leu Tyr Lys Ile Met Gly Asn Ala Phe Lys Lys Tyr Leu Glu Thr Phe 
    850                 855                 860                 


Ser Asn Gly Lys Glu Asn Val Tyr Ala Phe Leu Lys Arg Pro Lys Tyr 
865                 870                 875                 880 


Ile Leu Ser Asp Asn Lys Ile Ile Ser Leu Lys Asp Phe Asp Asp Arg 
                885                 890                 895     


Ser Ile Asn Glu Phe Ile Asn Lys Met Ser Gln Lys Val Lys Ile Lys 
            900                 905                 910         


Ile Tyr Gln Ser Leu Gln Asn Ser Val Thr Lys Tyr Asn Leu Tyr Ala 
        915                 920                 925             


Trp Tyr Met Thr Ala His Phe Leu Ala Gly Lys Gln Leu Asn Leu Leu 
    930                 935                 940                 


Ile Gly Asp Phe Lys Ala Phe Lys Gln Tyr Ile Arg Lys Ile Lys Gln 
945                 950                 955                 960 


Arg Ala Glu Asn Thr Gly Asn Ala His Lys Glu Met Asn Lys Asp Ile 
                965                 970                 975     


Ile Glu Asp Ile Val Glu Tyr Cys Asp Lys Val Ile Lys Ile Leu Glu 
            980                 985                 990         


Phe Val Leu Gln Phe Lys Gly Arg  Ile Thr Ala Asn Lys  Glu Asp Tyr 
        995                 1000                 1005             


Phe Ala  Asp Glu Glu Glu Tyr  Ala Glu Tyr Met Leu  Asn Phe Ile 
    1010                 1015                 1020             


Asp Tyr  Ser Glu Phe Ile Thr  Asn Asn Lys Ile Asn  Gly Lys Val 
    1025                 1030                 1035             


Asp Tyr  Ala Thr Ala Leu Lys  Glu Tyr Cys Lys Gln  Asn Met Glu 
    1040                 1045                 1050             


Asn Thr  Asn Ser Thr Asp Glu  Ile Met Gly Ile Tyr  Tyr Asp Gln 
    1055                 1060                 1065             


Lys Asn  Leu Ile Leu Asn Arg  Asn Val Val Tyr Ser  Lys Leu Tyr 
    1070                 1075                 1080             


Gly Glu  Ser His Met Leu His  His Cys Leu Cys Gly  Ala Asp Tyr 
    1085                 1090                 1095             


Asp Tyr  Arg Val Lys Gly Glu  Asp Ile Gln Asn Tyr  Tyr Asp Leu 
    1100                 1105                 1110             


Arg Lys  Asp Leu Asn Asn Val  Phe Lys Asn Gly Lys  Cys Thr Ser 
    1115                 1120                 1125             


Lys Asp  Asp Gln Ile Lys Leu  Lys Gln Phe Gln Asn  Leu Lys Asn 
    1130                 1135                 1140             


Lys Ile  Glu Leu Tyr Asp Ile  Lys Thr Tyr Thr Asp  Leu Val Asn 
    1145                 1150                 1155             


Asp Ile  Ile Ala Gln Phe Val  Ser Trp Ala Tyr Leu  Arg Glu Arg 
    1160                 1165                 1170             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Tyr His Tyr Ile  Lys Leu Phe 
    1175                 1180                 1185             


Trp Lys  Asn Glu Thr Asp Thr  Glu Lys Cys Lys Leu  Lys Glu Gln 
    1190                 1195                 1200             


Tyr Asn  Lys Leu Ser Phe Lys  Asp Lys Asn Lys Asn  Val Ile Asn 
    1205                 1210                 1215             


Ile Thr  Glu Gly Ala Leu Leu  His Gln Ile Val Ala  Val Tyr Asp 
    1220                 1225                 1230             


Tyr Thr  Leu Pro Ile Ile Asn  Gly Ser Arg Glu Lys  Thr Glu His 
    1235                 1240                 1245             


Asn Lys  Ile Ala Leu Ala Ser  Gly Thr Ser Gly Thr  Ser Leu Ile 
    1250                 1255                 1260             


Asn Phe  Ile Thr Asn Tyr Cys  Asn Glu Glu Ala Lys  Thr Gly Lys 
    1265                 1270                 1275             


Ala Glu  Thr Tyr Asn Asp Gly  Leu Asp Phe Phe Gly  Lys Glu Ile 
    1280                 1285                 1290             


Asn Arg  Asp Gly Phe Ile Leu  Asp Arg Lys Asp Ile  Ala His Met 
    1295                 1300                 1305             


Lys Tyr  Tyr Ile Phe His Glu  Lys Ser Ile Met Glu  Met Phe Ala 
    1310                 1315                 1320             


Asp Met  Tyr Asn Gly Phe Leu  Met Tyr Asp Thr Lys  Leu Lys Lys 
    1325                 1330                 1335             


Ser Val  Ser Phe Val Ser His  Asn Ile Leu Ala Arg  Tyr Phe Ile 
    1340                 1345                 1350             


Ile Met  Lys Thr Glu Met His  His Ala Ser Glu Glu  Asn Glu Lys 
    1355                 1360                 1365             


Phe Gly  Phe Asp Val Thr Leu  Tyr Ser Asp Lys Phe  Thr Tyr Lys 
    1370                 1375                 1380             


Tyr Glu  Glu Thr Cys Glu Asp  Glu Gln Lys Glu Gly  Glu Glu Lys 
    1385                 1390                 1395             


Gln Lys  Lys Val Asn Val Asp  Ala Arg Ser Glu Glu  Phe Leu Glu 
    1400                 1405                 1410             


Ile Val  Lys Arg Ile Leu Glu  Tyr Lys Glu Cys Lys  
    1415                 1420                 1425 


<210>  677
<211>  1287
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  677

Met Arg Ile Gly Lys Val Gln Gly Arg Thr Phe Thr Gly Phe Asp Asn 
1               5                   10                  15      


Ala Arg Gly Lys Thr Leu Arg Arg Arg Leu Leu Thr Arg Pro Asp Asn 
            20                  25                  30          


Glu Ala Arg Ser Leu Ser Glu His Leu Ala His Asp Pro Lys Ala Leu 
        35                  40                  45              


Ile Gly Gln Ala Ile Ser Arg Ile Asp Thr Ile Tyr Gln Lys Pro Lys 
    50                  55                  60                  


Thr Gly Lys Pro Thr Pro Glu Gln Phe Gly His Arg Asp Thr Leu Gly 
65                  70                  75                  80  


Trp Ala Tyr Trp Lys Leu Leu Val Ala Ser Tyr Pro Glu Val Glu Gly 
                85                  90                  95      


His Arg Asp Leu Phe Val Arg Arg Leu His Pro Tyr Gly Asp Thr Pro 
            100                 105                 110         


Pro Lys Ser His Gly Gln Lys Glu Gly Glu His Gln Lys Gly Gly Lys 
        115                 120                 125             


Pro Gln Leu Glu Gly Arg Trp His Gly Val Met Ala Gln His Gly Lys 
    130                 135                 140                 


Asn Pro Asp Gln Ile Ala Ala Arg Leu Phe Asp His Leu His Asn Ser 
145                 150                 155                 160 


Glu Leu Arg Phe Gly Gly Thr Ala Ser Gly Glu Pro Arg Thr Arg Pro 
                165                 170                 175     


Gly Lys Glu Ala Thr Pro Thr Gly Leu Ile Gly Ala Arg Ala Lys Thr 
            180                 185                 190         


Ile Glu His Ser Val Leu Pro Arg Asp Ala Lys Arg Phe Val Ala Glu 
        195                 200                 205             


Trp Arg Gly Glu Asp Gln Glu Arg Tyr Ala Gly Ala Arg Asp Ile Ala 
    210                 215                 220                 


Ala Ala Ile Ser Ala Gly Leu Asn Asp Lys Asp Gln Lys Ser Gly Ser 
225                 230                 235                 240 


Gly Arg Lys Ser Ala Val Ile Gly Lys Leu Leu Ser Asp His Leu Glu 
                245                 250                 255     


Thr Leu Thr Gly Asn Arg Lys Cys Arg Phe Asp Pro Lys Ser Thr Ala 
            260                 265                 270         


Glu Thr Leu Glu Leu Arg Asp Gly Glu Ser Val Asp Asp Arg Arg Arg 
        275                 280                 285             


Ile Leu Glu Leu His Ala Glu Val Lys Ala Thr Tyr Lys Arg Met Ala 
    290                 295                 300                 


Ala Trp Lys Pro Ala Lys Leu Pro Arg Asn Ser Asp Glu Leu Phe Arg 
305                 310                 315                 320 


Leu Val Arg Gln Gln Ala Asp Asn Arg Ile Leu Asn His Leu Val Arg 
                325                 330                 335     


Val Gly Arg Ile Ser Val Tyr Ser Glu Gln Ser Asp Ala Leu Ser Glu 
            340                 345                 350         


Ser Gln Phe Trp Thr Ser Gly Gly Gln Thr Gln Ile Lys Glu Ser Glu 
        355                 360                 365             


Val Phe Ala Arg Leu Trp Ile Gly Ala Ile Ser Arg Ala Ser Tyr Ser 
    370                 375                 380                 


Met Lys Ala Trp Leu Glu Pro Glu Gly Thr Val Phe Asn Pro Ser Ile 
385                 390                 395                 400 


Asn Asp Phe Asp Val Thr Ser Ser His Asn Thr Asn Arg Ile Leu Glu 
                405                 410                 415     


Asp Ser Gly Arg Leu Ser Asn Ala Met Ala Arg Arg Ala Ile Tyr Phe 
            420                 425                 430         


Gly Glu Thr Pro Glu Phe Asp Ala Leu Gly Glu Glu Asp Gln Arg Val 
        435                 440                 445             


Leu Val Lys Lys Cys Leu Asp Ala Leu Ser Ala Cys Arg Asn Arg Thr 
    450                 455                 460                 


Phe His His Gly Gln Arg Ala Lys Phe Leu Lys Glu Val Arg Lys Gly 
465                 470                 475                 480 


Leu Lys Glu Lys Glu Ala Asp Ser Ala Gly Pro Ala Ala Trp Glu Gly 
                485                 490                 495     


Ile Arg Glu Val Ile Gln Ala Asp Ala Arg Asn Leu Gly Ala Arg Leu 
            500                 505                 510         


Leu Gln Asp Leu Thr Gly Ala Lys Val His Ser Phe Ala Thr Asp Pro 
        515                 520                 525             


Glu Phe Arg His Leu Tyr Glu Ser Val Ala Ala Thr Leu Thr Ala Gly 
    530                 535                 540                 


Gly Glu Leu Glu Ala Ala Leu Pro Arg Leu Lys Asn Val Leu Lys Arg 
545                 550                 555                 560 


Ala Glu Gly Val Arg Cys Tyr Leu Asp Thr Pro Ser Gln Arg Arg Glu 
                565                 570                 575     


Gly Asp Glu Ser Leu Ile Ala Arg Leu Pro Val Ala Pro Val Pro Arg 
            580                 585                 590         


Glu Leu Asp Asp Ala Ala Thr Lys Ala Arg His Ser Ala Leu Leu Arg 
        595                 600                 605             


Leu Tyr Asp Gly Pro Phe Arg Pro Trp Ala Thr Glu Leu Arg Gly Glu 
    610                 615                 620                 


Arg Leu Ser Asp Tyr Ala Ala Arg Ala Lys Arg Leu Ala Thr Arg Leu 
625                 630                 635                 640 


Ala Lys Ser Thr Asn Thr Ala Ser Pro Tyr Pro Asp Ser Val Glu Gly 
                645                 650                 655     


Arg Ser Val Arg Leu Arg Asp Pro Ile Thr Ala Asp Thr Ala Pro Glu 
            660                 665                 670         


Thr Leu Lys Thr Tyr Leu Ser Ala Leu Thr Ala Glu Thr Ala Thr Glu 
        675                 680                 685             


Phe Arg Val Gln Lys Gly Tyr Glu Ser Asp Gly Glu Lys Ala Lys Glu 
    690                 695                 700                 


Gln Ala Glu Phe Ile Glu Asp Phe Arg Arg Asp Met Ile Ala Leu Ala 
705                 710                 715                 720 


Phe Gln Asp Phe Ile Arg Asp His Gly Phe Ala Trp Leu Leu Asp Ile 
                725                 730                 735     


Ala Ser Lys Ala Glu Pro Ser Asn Asp Ala Pro Asn Leu Pro Asp Pro 
            740                 745                 750         


Val Asp Thr Gly Lys Asp Thr Val Phe Glu Asp Trp Gln Ala Leu Leu 
        755                 760                 765             


Tyr Leu Phe Leu His Phe Val Pro Ala Asp Asp Val Ser Gln Leu Leu 
    770                 775                 780                 


His Gln Leu Arg Lys Trp Asp Ala Leu Gln Asp Lys Tyr Glu Leu Ala 
785                 790                 795                 800 


Glu Pro Gly Glu Thr Leu Gly Gln Thr Lys Ala Asp Thr Arg Lys Ile 
                805                 810                 815     


Val Gly Gln Phe Arg Asp Cys Leu Thr Leu Phe Leu Lys Thr Gly Asp 
            820                 825                 830         


Ala Arg Phe Asp Gly Glu Gly Val Glu Leu Pro Leu Ser Asp Phe Gln 
        835                 840                 845             


Glu Leu Phe Glu Ser Pro Ala Thr Phe Lys Glu Leu Phe Leu Ala Glu 
    850                 855                 860                 


Pro Ala Glu Asn Asp Ala Ser Glu Thr Asp Asp Gln Asp Ala Pro Gly 
865                 870                 875                 880 


Glu Lys His Arg Val Thr Arg Thr Arg Arg Gly Leu Arg Gln Ile Leu 
                885                 890                 895     


Arg Tyr Asn His Met Pro Val Leu Arg Asp Leu Phe Leu Ala His Lys 
            900                 905                 910         


Val Thr Asp Ala Glu Val Asp Gly Leu Gln Ala Leu Glu Val Asp Asp 
        915                 920                 925             


Pro Gln Thr Gly Glu Ser Gln Ile Gly Ala Ala Gln Arg Ile Arg Thr 
    930                 935                 940                 


Glu Ile His His His Thr Ser Asn Asp Lys Gln Ile Ser Glu Ala Lys 
945                 950                 955                 960 


Val Glu Glu Tyr Arg Arg Ala Leu Ser Thr Ile Glu Arg His Arg Phe 
                965                 970                 975     


Leu Val Gly Arg Val Tyr Leu Gly Asp His Ile Arg Val His Lys Leu 
            980                 985                 990         


Met Met Asp Val Met Gly Arg Leu  Val Asp Phe Ala Gly  Ala Trp Glu 
        995                 1000                 1005             


Arg Glu  Ala Ala Asp Gly Asp  Arg Lys Gly Phe Ile  Ser Arg Ala 
    1010                 1015                 1020             


Ile Ala  Leu Pro Glu Val Ala  Glu Gly Tyr Ala Ala  Asp Arg Leu 
    1025                 1030                 1035             


Lys Thr  Val Ala Arg Arg Val  Leu Asp Asp Gly Glu  Ala Arg Arg 
    1040                 1045                 1050             


Ile Arg  Asn Asp Leu Gly His  Phe Asn Asp Leu Ala  Pro Thr Ser 
    1055                 1060                 1065             


Gly Pro  Ala Asn Leu Thr Phe  Val Val Asn Arg Ala  Arg Arg Met 
    1070                 1075                 1080             


Met Arg  His Asp Arg Lys Arg  Lys Asn Ala Val Thr  Lys Ser Val 
    1085                 1090                 1095             


Ile Glu  Ile Leu Asn Arg Gln  Gly Leu Gly Ile Glu  Trp Thr Met 
    1100                 1105                 1110             


Arg Asn  His Glu Leu Cys Glu  Ala Lys Leu Trp Gln  Asn Pro Val 
    1115                 1120                 1125             


Lys His  Leu Gly Phe Ala Thr  Leu Glu Gly Arg Gly  Lys Lys Trp 
    1130                 1135                 1140             


Arg Arg  Pro Phe Glu Ala Arg  Tyr Gly Asp Ala Tyr  Met Ala Met 
    1145                 1150                 1155             


Val Ala  Gln Leu Phe Asp Gly  Thr Val Thr Ser Pro  Pro Ala Lys 
    1160                 1165                 1170             


Gly Pro  Pro Gln Ser Gly Lys  Ser Gly Gly Lys Pro  Gly Lys Gly 
    1175                 1180                 1185             


Ala Glu  Gly Gly Ala Lys Glu  Lys Ser Arg Ser Pro  Thr Arg Met 
    1190                 1195                 1200             


Glu Glu  Gly Gly Val Tyr Glu  Gly Arg Val Ala Lys  Ala Lys Ser 
    1205                 1210                 1215             


Asp Lys  Gly Phe Gly Phe Leu  Leu Val Glu Gly Ala  Gln Glu Glu 
    1220                 1225                 1230             


Ile Phe  Leu His Ile Tyr Gly  Ile Ser Gly Asn Arg  Pro Ala Arg 
    1235                 1240                 1245             


Ile Glu  Asn Gly Gln Arg Tyr  Arg Phe Thr Leu Gly  Ile Asp Arg 
    1250                 1255                 1260             


Asp Arg  Glu Arg Arg Lys Glu  Arg Ala Trp Val Ala  Arg Glu Ala 
    1265                 1270                 1275             


Val Arg  Ile Asp Glu Asn Arg  Ser Lys 
    1280                 1285         


<210>  678
<211>  1373
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  678

Met Ala Lys His Leu Arg Pro Ile Gly Glu Ser Tyr Thr Asp Phe Leu 
1               5                   10                  15      


Asp Glu Thr Glu Phe Val Arg Leu Gly Arg Gly Leu His Arg Gly His 
            20                  25                  30          


His Gly Val Gln Ile Pro Pro Thr Glu Leu Pro Ser Tyr Leu Ala Glu 
        35                  40                  45              


Tyr Arg Lys Ala Leu Met Arg Gln Val Val Ala Val Leu Asp Lys Val 
    50                  55                  60                  


Val Gly Lys Arg Arg Arg Leu Ser Gly Met His Pro Glu Ala Tyr Arg 
65                  70                  75                  80  


Asp Arg Val His Leu Ala Glu Ala Leu Trp Val Arg Leu Val Ala Arg 
                85                  90                  95      


Val Lys Glu Ile Gly Thr Pro Pro Asp Pro Ser Glu Leu Leu Asp Leu 
            100                 105                 110         


Arg Arg Met Trp Asn Ala Lys Ala His Pro Tyr Ala Glu Tyr Asp Val 
        115                 120                 125             


Val Pro Arg Ala Pro Leu Asn Asp Gly Asn Gly Gln Lys Ile Leu Glu 
    130                 135                 140                 


Cys Arg Glu Val Asp Asp Pro Lys Ile Glu Arg Ser Asp Phe Glu Gly 
145                 150                 155                 160 


Arg Trp His Gly Arg Phe Trp Gln Ser Glu Pro Gly Pro Val Asp Tyr 
                165                 170                 175     


Asn Ala Ile Ala Asp Arg Ile Phe Ala His Leu Phe Asp Gln Glu Ala 
            180                 185                 190         


Val Ile Gly Gly Gly Pro Arg Arg Glu Gly Asn Val Thr Val Pro Asp 
        195                 200                 205             


Glu Asp Ile Asn Gly Gln Pro Gly Pro Ala Thr Gly Lys Gly Leu Ile 
    210                 215                 220                 


Ile Ala Arg Gly Gln Ser Ile Val Lys Ser Ala Ser Asp Pro Arg Arg 
225                 230                 235                 240 


Ser Ser Lys Lys Val Gln Arg Thr Trp Asp Lys Ala Val Glu Arg Arg 
                245                 250                 255     


Tyr Phe Gly Asp Asp Gly Lys Gly Gly Ser Asp Ile Ala Lys Ala Ile 
            260                 265                 270         


Tyr Glu Glu Leu Gly Asp Pro Ala Thr Leu Ala Asp Pro Ile Tyr Ala 
        275                 280                 285             


Ser Trp Phe Gly Ser Arg Leu Tyr Asp His Phe Gly Ser Phe Lys Asn 
    290                 295                 300                 


Ser Leu Pro Leu Glu Leu Lys Asp Pro Phe Lys Glu Gln Ile Trp Ala 
305                 310                 315                 320 


Leu His Asn Ser Val Arg Gln Phe Tyr Gln Arg Met Ala Lys Ser Asp 
                325                 330                 335     


Arg Phe Arg Leu Ala Leu Gln Asn Ala Arg Ser Glu Val Pro Asp Arg 
            340                 345                 350         


Ser Glu Leu Leu Ala Leu Leu Pro Lys Asp His Asp His Leu Leu Leu 
        355                 360                 365             


Val Leu Gly Gly Lys Lys Lys Asn Ala Glu Met Ser Glu Leu Ile Arg 
    370                 375                 380                 


Leu Gly Lys Leu Phe Val His Ala Ser Asp Val Leu His Asp Phe Asp 
385                 390                 395                 400 


Ala Asn Asp Ala Ala Ala Leu Asp Ala Phe Lys Arg Arg Met Ser Phe 
                405                 410                 415     


Leu Ala Thr Ser Ile Gly Gln Ser Glu Ile Lys Gln Thr Glu Thr Phe 
            420                 425                 430         


Ala Arg Thr Trp Arg Gly Ala Val Gly Leu Thr Leu Arg Thr Val Lys 
        435                 440                 445             


Gly Leu Ala Asp Pro Arg Gly Ile Ile Gly Thr Pro Asp Asn Arg Asp 
    450                 455                 460                 


Leu Gly Thr Ala Gly Pro Met Lys Asp Ala Phe Asn Lys Phe Asp Gln 
465                 470                 475                 480 


Pro His Phe Gln Gln His Met Thr Ile Ile Phe Gly Asn Lys Glu Leu 
                485                 490                 495     


Gln Ala Glu Gly Asn Pro Thr Arg Ser Ser Val Phe Thr Ala Asn Gly 
            500                 505                 510         


Asp Lys Asp His Gln Ala Glu Leu Leu Trp Gly Phe Leu Cys Val Val 
        515                 520                 525             


Arg Ser Val Arg Asn Arg Thr Asn His Tyr Asn Val Arg Arg Ala Leu 
    530                 535                 540                 


Leu Arg Leu Leu Asp Glu Gly Ile Val Ser Pro Met Pro Ser Asp Pro 
545                 550                 555                 560 


Lys Lys Glu Arg Val Glu Asn Arg Asn Leu Cys Thr Val Ser Pro Thr 
                565                 570                 575     


Ala Leu Glu Ala Phe Arg Arg Leu Leu Asn Phe Asp Leu Ala Ile Gln 
            580                 585                 590         


Lys Glu Ala Val Arg Thr Ala Leu Glu Gln Ala Lys Ala Ser Glu Phe 
        595                 600                 605             


Val Glu Glu Gly Lys Leu Arg Gly Leu Val Ser Glu Leu Ala Gly Thr 
    610                 615                 620                 


Glu Asp Met Pro Ala Leu His Ile Pro Arg Phe Ser Ala Val Met Asp 
625                 630                 635                 640 


Lys Val Arg Arg Leu Ala Asp Asn Arg Asp Val Gly Leu Asp Pro Ile 
                645                 650                 655     


Leu Ser Thr Leu Gln Arg Ser Leu Pro Pro Thr Asp Lys Gln Ala Glu 
            660                 665                 670         


Ser Asp Ala Ala Arg Cys Arg Tyr Arg Leu Leu Leu Glu Leu Tyr Lys 
        675                 680                 685             


Ser Gly Phe Arg Ser Trp Phe Ser Gly Ile Gln Ser Asn Glu Glu Asn 
    690                 695                 700                 


Asn Arg Glu Ile Cys His Trp Ala Val Lys Gln Val Gly Arg Ala Lys 
705                 710                 715                 720 


Asp Ala Arg Lys Ser Glu Tyr Asp Lys Lys Thr Lys Arg His Tyr Arg 
                725                 730                 735     


Ser Pro Asn Ser Leu Ile Asp Asp Leu Gly Leu Asp Lys Phe Asp Asp 
            740                 745                 750         


Leu Thr Asp Leu Leu Glu Ala Leu Ala Ser Gln Ser Thr Arg Glu His 
        755                 760                 765             


Asp Gln Asn Leu Lys Tyr Val Pro Asp Ala Arg Val Gln Ser Gln Met 
    770                 775                 780                 


Ser Asn Arg Ile Glu Glu Phe Arg Gln Glu Leu Phe Ala His Ile Phe 
785                 790                 795                 800 


Thr Lys Tyr Leu Asp Thr His Asp Phe Gly Trp Ile Gly Ala Ile Glu 
                805                 810                 815     


Val Arg Arg Glu Ala Cys Asp Leu Ala Asp Val Val Ser Ala Phe Glu 
            820                 825                 830         


Val Arg Asp Gln Lys Phe Asp Ala Asp Trp His Ser Gln Phe Tyr Ala 
        835                 840                 845             


Trp Leu Tyr Met Val Pro Pro Ile Glu Ala Ser Arg Leu Arg His Gln 
    850                 855                 860                 


Met Arg Lys Ser Ala Val Met Asp Asp Lys Trp Ser Thr Thr Leu Glu 
865                 870                 875                 880 


Leu Thr Ser Gly Asp Arg Lys Thr Arg Asp Asp His Ala Gln Asp Val 
                885                 890                 895     


Leu Ala Asp Met Asp Arg Leu Phe Ser Leu Tyr Thr Lys Val Gln Ala 
            900                 905                 910         


Ala Gly Phe Asn Gly Gln Glu His Glu Ser Ala Leu Gly Ser Lys Ser 
        915                 920                 925             


Leu Phe Tyr Glu Asp Gly Asn Gln Phe Asp Glu Val Tyr Ser Pro Asp 
    930                 935                 940                 


Thr Glu Thr His Asn Lys Thr Phe Pro Gly Thr Arg Arg Gly Leu Arg 
945                 950                 955                 960 


Gln Leu Val Arg Tyr Ala His Leu Pro Ala Leu Glu Gly Val Phe Lys 
                965                 970                 975     


Lys His Arg Ile Thr Lys Ala Glu Val Glu Thr Phe Val Ala Leu Tyr 
            980                 985                 990         


Asp Glu Asn Arg Arg Asp Pro Gly  Ser Val Ala His Met  Leu Arg Arg 
        995                 1000                 1005             


Glu Lys  Leu Arg Thr Glu Ile  Leu Arg Ser Ile His  Asp Gly Pro 
    1010                 1015                 1020             


Lys Pro  Lys Asp Lys Asp Phe  Trp Pro Lys Leu Glu  Ala Lys Cys 
    1025                 1030                 1035             


Leu Glu  Tyr Arg Thr Val Ala  Thr Glu Thr Ala Ile  Tyr Asn Phe 
    1040                 1045                 1050             


Gln Ala  Asn Ala Ala Arg Leu  Asn Asp His Ala Arg  Leu His Gln 
    1055                 1060                 1065             


Ile Val  Met Arg Val Val Ala  Arg Leu Thr Asp Tyr  Ala Leu Ile 
    1070                 1075                 1080             


Trp Glu  Arg Asp Arg Leu Phe  Ala Phe Val Gly Met  Leu Tyr Arg 
    1085                 1090                 1095             


Gln Thr  Gly Gly Thr Gly Ile  Asn Pro Ala Met Arg  His Ala Glu 
    1100                 1105                 1110             


Lys Thr  Asn Ala Pro Pro Arg  Ile Gly Ile Leu Val  Ser Asp Ser 
    1115                 1120                 1125             


Ala Leu  Ala Lys Lys Leu Asn  Ser Asn Ser Ala Glu  Val Phe Ile 
    1130                 1135                 1140             


Pro Tyr  Leu Asp Thr Glu Thr  Gly Phe Asp Ala Pro  Arg Phe Asp 
    1145                 1150                 1155             


Asp Leu  Cys Thr Leu Leu Ser  His Glu His Ala Lys  Glu Phe Arg 
    1160                 1165                 1170             


Phe His  Phe Leu Glu Val Gly  Glu Glu Asn Ser Lys  Asp Glu Ala 
    1175                 1180                 1185             


Arg Arg  Leu Asn Glu Glu Thr  Met Gly His Arg Lys  Arg Pro Ala 
    1190                 1195                 1200             


Phe Lys  Arg Gly Thr Arg Arg  Gln Gly Ile Arg Asn  Asp Leu Ala 
    1205                 1210                 1215             


His His  Asn Val Leu Asp Leu  Ala Gly Gly Ala Gly  Pro Asn Leu 
    1220                 1225                 1230             


Thr Tyr  Val Val Asn Ala Val  Arg Ser Leu Leu Ser  Tyr Asp Arg 
    1235                 1240                 1245             


Lys Leu  Lys Asn Ala Val Pro  Lys Ser Ile Lys Arg  Ile Leu Gly 
    1250                 1255                 1260             


Glu Glu  Gly Leu Ile Ile Glu  Trp Gln Met Asn Tyr  Asp Arg Leu 
    1265                 1270                 1275             


Lys Lys  Pro Thr Val Tyr Pro  Asn Val Glu Thr His  Leu Thr Met 
    1280                 1285                 1290             


Val Pro  Pro Arg His Met Thr  Ala Pro Val Ser Phe  Thr Leu Pro 
    1295                 1300                 1305             


Arg Ala  Ser Val Arg Leu Ala  Ser Met Val Lys Ala  Val Phe Asp 
    1310                 1315                 1320             


Phe Gly  Ser Ser Gly Tyr Gly  Glu Glu Arg Met Ile  Gly Gly Arg 
    1325                 1330                 1335             


Thr Ala  Lys Gln Ala Val Tyr  Pro Asp Asp Phe Thr  Arg Arg Phe 
    1340                 1345                 1350             


Pro Gln  Thr Pro Met Gly Leu  Lys Gln Ala Thr Arg  Leu Val Phe 
    1355                 1360                 1365             


Ala Ser  Glu Asn Ser 
    1370             


<210>  679
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  679

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Asp Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn Tyr Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Gly Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Gly Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Lys Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  680
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  680

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Lys Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Leu Tyr Gln Ile Val  Ser Ala Phe Asn Phe  Gly Ser Lys 
    1205                 1210                 1215             


Leu Leu  Tyr Ile Ser Glu Asp  Gly Arg Trp Lys Met  Ala Gly Gly 
    1220                 1225                 1230             


Ala Phe  Pro Gly Lys Tyr Gly  Arg Phe Glu Asn Asp  Tyr Asn His 
    1235                 1240                 1245             


Arg Thr  Ser Leu Ser Lys Val  Ile Arg Leu Phe Glu  Asn Glu Ser 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ile Ile Tyr  Trp Arg Asp Tyr Val  Asp His Met 
    1265                 1270                 1275             


Lys Tyr  Tyr Val Asn Gln Asn  Gln Ser Ile Met Glu  Ile Tyr Ser 
    1280                 1285                 1290             


Ala Phe  Tyr Ser Lys Val Leu  Gly Tyr Ser Ala Lys  Leu Arg Lys 
    1295                 1300                 1305             


Ser Val  Val Phe Asn Leu Gln  Ala Ala Leu Glu Lys  His His Ile 
    1310                 1315                 1320             


Asn Pro  Glu Cys Ile Trp Met  Thr Ser Asp Gly Lys  Cys Ala Asp 
    1325                 1330                 1335             


Ile Lys  Leu Met Lys Asn Leu  Glu Ser Gln Lys Phe  Thr Tyr Lys 
    1340                 1345                 1350             


Leu Ala  Lys Arg Glu Gly Glu  Lys Thr Glu Arg Lys  Ile Cys Met 
    1355                 1360                 1365             


Asn Ala  Leu Asn Glu Asn Phe  Leu Lys Thr Ile Arg  Thr Ser Leu 
    1370                 1375                 1380             


Glu Tyr  Lys Lys 
    1385         


<210>  681
<211>  1330
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  681

Met Lys Arg Glu Lys Asn Ile Thr Ile Met Lys Ile Ser Lys Val Asn 
1               5                   10                  15      


His Arg Arg Thr Ala Val Ala Leu Asn Gly Asp Lys Ser Glu Leu Gly 
            20                  25                  30          


Gly Ile Leu Tyr Glu Ala Pro Val Gln Lys Asp Arg Asn Gly Asn Tyr 
        35                  40                  45              


Asn Asp Val Ile Ala Glu Thr Gly Lys Val Val Asn Glu Ala Leu Asp 
    50                  55                  60                  


Lys Lys Ser Arg Leu Tyr Thr Pro Phe Asn Asn Gln Lys Val Ile Ile 
65                  70                  75                  80  


Asp Lys Asn Leu Gln Arg Tyr Ala Asn Asn Leu Lys Arg Cys Tyr Ile 
                85                  90                  95      


Asn Phe Val Lys Gln Tyr Val Asn Asn Lys Ser Phe Asn Tyr Lys Ala 
            100                 105                 110         


Met Gln Phe Ile Pro Asp Ile Gln Asn Pro Lys Thr Asn Asp Ala Val 
        115                 120                 125             


Asn Tyr Arg Thr Asp Arg Asp Asn Val Tyr Asn Lys Asn Lys Tyr Tyr 
    130                 135                 140                 


Asp Lys Gln Thr Lys Ser Lys Ser Lys Lys Phe Ile Tyr Glu Lys Ile 
145                 150                 155                 160 


Val Ile Pro Gln Asn Glu Gln Asn Ile Val Ile Ser Ala Leu Val Asn 
                165                 170                 175     


Cys Ser Leu Arg Lys Ser Leu Arg Lys Asp Val Ser Tyr Lys Thr Lys 
            180                 185                 190         


Thr Gly Glu Ile Lys Thr Tyr Asn Leu Pro Glu Leu Val Lys Lys Ser 
        195                 200                 205             


Met Arg Phe Tyr Cys Leu Glu Gly Gln Arg Glu Pro Asp Glu Lys Glu 
    210                 215                 220                 


Lys Tyr Glu Met Tyr Ile Leu Phe Ser Tyr Met Lys Glu Asp Lys Arg 
225                 230                 235                 240 


Thr Lys Asn Thr Asp Leu Leu Val Lys Ser Ile Ser Asn Gln Asn Thr 
                245                 250                 255     


Lys Val Lys Val Glu Asp Ile Asp Gly Asn Lys Leu Leu Lys Leu Ser 
            260                 265                 270         


Ile Ala Asp Thr Lys Lys Lys Pro Leu Trp Glu Tyr Leu Ile Lys Tyr 
        275                 280                 285             


Ala Asp Ser Ser Arg Gln Arg Glu Leu Met Tyr Asp Ile Arg Lys Lys 
    290                 295                 300                 


Ile Val Leu Tyr Val Ala Gly Ile Glu Glu Tyr Glu Asn Ile Lys Glu 
305                 310                 315                 320 


Asp Ser Gly Leu Ser Lys Val Ser Trp Ser Lys Tyr Asn Ile Ser Asp 
                325                 330                 335     


Asn Lys Met Phe Phe Asp Ile Asn Ser Cys Thr Asp Lys Arg Lys Gln 
            340                 345                 350         


Asn Leu Glu Ile Lys Ile Arg Glu Ala Asn Ile Glu His Tyr Arg Asn 
        355                 360                 365             


Ala Ser Ser Lys Leu Cys Asp Asp Glu Ser Ile Phe Trp Phe Gln His 
    370                 375                 380                 


Phe Glu Gly Val Ile Glu Thr Leu Phe Ser Lys Lys Ser Lys Ile Ser 
385                 390                 395                 400 


Glu Glu Arg Leu Gly Cys Ala Tyr Ile Cys Asp Tyr Leu Trp Lys Asp 
                405                 410                 415     


Phe Leu Ser Tyr Leu Ala Ala Lys Tyr Ile Asp Leu Gly Lys Gly Val 
            420                 425                 430         


Tyr His Phe Thr Met Lys Asp Lys Leu Asp Met Leu Asn Lys Asn Glu 
        435                 440                 445             


Ala Val Thr Asp Leu Arg Phe Gly Ile Val Ser Glu Lys Tyr Glu Lys 
    450                 455                 460                 


Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Glu Leu 
465                 470                 475                 480 


Asp Arg Asn Ile Ala Ala Tyr Val Thr Phe Ala Ala Asp Ile Phe Ala 
                485                 490                 495     


Lys Ser Val Ile Lys Ser Asp Tyr Arg Thr Lys Lys Asp Asn Asn Ser 
            500                 505                 510         


Asp Val Leu Gln Tyr Ser Asp Lys Glu Phe Arg Asn Ser Glu Val Ile 
        515                 520                 525             


Arg Asp Asn Ala Glu Lys Asn Ile Leu Gln Tyr Trp Gly Gly Tyr Ser 
    530                 535                 540                 


Arg Trp Gly Thr Glu Asn Ser Lys Leu Pro Glu Asn Asn Lys Val Ser 
545                 550                 555                 560 


Asp Phe Gly Lys Leu Asp Val Ser Asp Leu Cys Ile Asp Ile Lys Lys 
                565                 570                 575     


His Leu Ala Gly Ile Arg Asn Ser Ser Val His Tyr Thr Thr Lys Ile 
            580                 585                 590         


Lys Asn Glu Ser Ala Ala Asp Gly Ser Asn Val Lys Ile Leu Phe Glu 
        595                 600                 605             


Lys Asp Leu Ala Asp Ile Asn Ile Ile Tyr Ala Asp Lys Tyr Tyr Ser 
    610                 615                 620                 


Asn Asn Val Trp Met Phe Tyr Ser Leu Glu Asp Ile Asn Lys Leu Ile 
625                 630                 635                 640 


Ala Phe Leu Tyr Lys Glu Lys Arg Val Ile Arg Gln Val Gln Ile Pro 
                645                 650                 655     


Ser Phe Ser Arg Ile Leu Lys Arg Lys Ala Met Gln Asp Val Ile Asn 
            660                 665                 670         


Glu Ile Phe Lys Asp Asp Phe Asp Glu Asn Ile Val Asn Pro Glu Leu 
        675                 680                 685             


Lys Glu Lys Tyr Arg Asn Ser Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
    690                 695                 700                 


Tyr Asn Ala Phe Ile Ile Gln Pro Glu Leu Lys Glu Lys Phe Lys Asp 
705                 710                 715                 720 


Lys Ile Lys Thr Met Lys Ser Glu Leu Tyr Asn Lys Leu Lys Thr Ile 
                725                 730                 735     


Asp Lys Lys Glu Tyr Lys Ala Leu Tyr Cys Met Leu Ser Asn Glu Glu 
            740                 745                 750         


Ser Ala Leu Lys Asn Phe Ala Asp Arg Ile Tyr Ser Val Asp Gly Asp 
        755                 760                 765             


Asn Val Ser Phe Ala Asp Ile Cys Lys Ile Leu Met Thr Asp Tyr Asn 
    770                 775                 780                 


Met Gln Asn Gln Glu Lys Lys Asn Ile Glu Ser Met Glu Gln Lys Lys 
785                 790                 795                 800 


Lys Asn Lys Gly Lys Asp Glu Asn Tyr Lys His Phe Pro Leu Leu Leu 
                805                 810                 815     


His Lys Val Leu Lys Glu Leu Phe Ile Glu Tyr Leu Lys Gln Thr His 
            820                 825                 830         


Glu Leu Glu Phe Leu Arg Asn Asn Ile Cys Ile Lys Ser Asp Val Thr 
        835                 840                 845             


Met Glu Ser Phe Glu Ser Gln Ile Lys Gly Val Glu Ile Tyr Lys Asp 
    850                 855                 860                 


Leu Lys Glu Lys Ile Asp Lys Asn Asn Ser Leu Leu Asp Trp Tyr Val 
865                 870                 875                 880 


Ile Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asn 
                885                 890                 895     


Ile Lys Asn Tyr Ile Gln Phe Ala Thr Asn Ile Asp Lys Arg Ala Glu 
            900                 905                 910         


Ser Val Lys Asn Leu Thr Glu Ser Gly Met Val Lys Arg Ile Gln Tyr 
        915                 920                 925             


Tyr Asp Asp Ile Val Arg Thr Leu Glu Phe Ser Ala Gln Tyr Ile Gly 
    930                 935                 940                 


Lys Ile Ser Asn Asn Ile Asn Asp Tyr Phe Asn Ser Glu Asp Glu Tyr 
945                 950                 955                 960 


Val Ser Phe Leu Ser Lys Tyr Val Gly Phe Ile Asn Asp Lys Ser Glu 
                965                 970                 975     


Asp Val Leu Thr Glu Leu Lys Asp Phe Cys Arg Glu Lys Ile Asn Asn 
            980                 985                 990         


Gly Ser Gln Ile Ile Gly Ile Tyr  Tyr Gly Gly Asp Asn  Val Ile Ile 
        995                 1000                 1005             


Asn Arg  Asn Val Ile Tyr Ala  Gln Met Tyr Ser Asn  Ala Glu Val 
    1010                 1015                 1020             


Phe Ser  Asn Ile Tyr Lys Lys  Val Thr Lys Asn Asp  Ile Ile Asn 
    1025                 1030                 1035             


Tyr Tyr  Glu Lys Gln Asn Asp  Leu Lys Asp Val Phe  Lys Ser Gly 
    1040                 1045                 1050             


Val Cys  Gln Asn Glu Asp Glu  Gln Arg Ser Leu Cys  Glu Phe Gln 
    1055                 1060                 1065             


Gln Leu  Lys Asn Arg Ile Glu  Leu Thr Glu Leu Ser  Thr Tyr Ala 
    1070                 1075                 1080             


Asp Met  Val Asn Asp Phe Met  Ala Gln Phe Val Glu  Trp Ala Tyr 
    1085                 1090                 1095             


Leu Arg  Glu Arg Asp Leu Met  Tyr Phe Gln Leu Gly  Ile His Tyr 
    1100                 1105                 1110             


Ile Arg  Leu Phe Tyr Ser Asp  Asn Val Leu Asp Glu  Lys Tyr His 
    1115                 1120                 1125             


Lys Leu  Ser Asp Asn Val Ile  Asp Ile Glu Glu Gly  Ala Leu Leu 
    1130                 1135                 1140             


Tyr Gln  Ile Val Ala Met Tyr  Asp Tyr Glu Leu Arg  Ile Phe Glu 
    1145                 1150                 1155             


Thr Asp  Asn Phe Gly Asn Ala  Lys Arg Ile Gly Gln  Gly Gly Pro 
    1160                 1165                 1170             


Gly Lys  Ser Ile Pro Val Phe  Leu Lys Lys Tyr Cys  Asn Gly Thr 
    1175                 1180                 1185             


Asp Val  Tyr Glu Cys Gly Leu  Glu Leu Phe Glu Asp  Ile Asn Gln 
    1190                 1195                 1200             


His Glu  His Ile Ile Arg Phe  Arg Asn Asp Ile Ala  His Met Arg 
    1205                 1210                 1215             


Tyr Met  Ser Asn Gln Ala Met  Asn Ile Met Ser Ile  Val Ser Asn 
    1220                 1225                 1230             


Ile Tyr  Lys Ser Phe Phe Val  Tyr Asp Thr Lys Leu  Lys Lys Ser 
    1235                 1240                 1245             


Ile Ser  Leu Val Phe Lys Asn  Ile Leu Met Arg Tyr  Gly Val Ile 
    1250                 1255                 1260             


Ala Asp  Leu Val Phe Ser Tyr  Asn Asn Lys Asn Gln  Ser Ile Lys 
    1265                 1270                 1275             


Asp Asp  Met Asp Ile Asn Ile  Ile Asn Ile Lys Asn  Leu Lys Ser 
    1280                 1285                 1290             


Asp Lys  Tyr Val Tyr Lys Ile  Val Asn Glu Asp Ile  Val Lys Gln 
    1295                 1300                 1305             


Val Glu  Ile Glu Ile Arg Asn  Gln Val Phe Leu Glu  Gln Leu His 
    1310                 1315                 1320             


Lys Leu  Leu Tyr Phe Ser Arg  
    1325                 1330 


<210>  682
<211>  1358
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  682

Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser Val Ala 
1               5                   10                  15      


Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu Tyr Tyr 
            20                  25                  30          


Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp Leu Glu 
        35                  40                  45              


Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr Asn Val 
    50                  55                  60                  


Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln Lys Met 
65                  70                  75                  80  


Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn Ala Leu 
                85                  90                  95      


Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val Glu Lys 
            100                 105                 110         


Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys Met Lys 
        115                 120                 125             


Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe Pro Glu 
    130                 135                 140                 


Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser Lys Glu 
145                 150                 155                 160 


Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys Leu Lys 
                165                 170                 175     


Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg Met Gln 
            180                 185                 190         


Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu Tyr Gly 
        195                 200                 205             


Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe Glu Lys 
    210                 215                 220                 


Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile Val Lys 
225                 230                 235                 240 


Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys Asp Gly 
                245                 250                 255     


Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys Lys Tyr 
            260                 265                 270         


Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys Glu Lys 
        275                 280                 285             


Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr Leu Cys 
    290                 295                 300                 


Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp Met Thr 
305                 310                 315                 320 


Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu Asn Glu 
                325                 330                 335     


Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn Leu Lys 
            340                 345                 350         


Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala Val Asn 
        355                 360                 365             


Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile Arg Glu 
    370                 375                 380                 


Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr Ile Asp 
385                 390                 395                 400 


Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp Gly Tyr 
                405                 410                 415     


Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu Trp Thr 
            420                 425                 430         


Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val Tyr His 
        435                 440                 445             


Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro Ile Ser 
    450                 455                 460                 


Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly Phe Asp 
465                 470                 475                 480 


Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met Glu Lys 
                485                 490                 495     


Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr Pro Glu 
            500                 505                 510         


Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met Lys Thr 
        515                 520                 525             


Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln Lys Lys 
    530                 535                 540                 


His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp Ala Asp 
545                 550                 555                 560 


Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg Glu Lys 
                565                 570                 575     


Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr Lys Glu 
            580                 585                 590         


Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His Tyr Thr 
        595                 600                 605             


Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala Glu Tyr 
    610                 615                 620                 


Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg Glu Lys 
625                 630                 635                 640 


Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val Ile Asn 
                645                 650                 655     


Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala Ala Gln 
            660                 665                 670         


Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro Gln Val 
        675                 680                 685             


Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met Asn Cys 
    690                 695                 700                 


Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe Phe Val 
705                 710                 715                 720 


Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys Lys Pro 
                725                 730                 735     


Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys Leu Ser 
            740                 745                 750         


Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser Phe Gly 
        755                 760                 765             


Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala Ile Cys 
    770                 775                 780                 


Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile Ser Met 
785                 790                 795                 800 


Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys Gln Ile 
                805                 810                 815     


Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu Ala Phe 
            820                 825                 830         


Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro Val Leu 
        835                 840                 845             


Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp Gly Leu 
    850                 855                 860                 


Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn Asp Ala 
865                 870                 875                 880 


Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn Gln Lys 
                885                 890                 895     


Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln Phe Thr 
            900                 905                 910         


Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val Asp Asn 
        915                 920                 925             


Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu Ile Leu 
    930                 935                 940                 


Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met Glu Asp 
945                 950                 955                 960 


Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly Phe Val 
                965                 970                 975     


Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala Leu Tyr 
            980                 985                 990         


Ser Phe Cys Lys Gln Lys Phe Lys  Val Asp Gly Lys Glu  Tyr Met Ala 
        995                 1000                 1005             


Gly Ile  Tyr Tyr Asp Gly Glu  Asn Leu Ile Pro Asn  Arg Asn Ile 
    1010                 1015                 1020             


Ile Arg  Ala Asn Met Tyr Gly  Asn Thr Ser Cys Leu  Lys Pro Cys 
    1025                 1030                 1035             


Met Asp  Arg Ile Thr Leu Lys  Glu Ile Arg Thr Met  Tyr Ala Asp 
    1040                 1045                 1050             


Gln Asn  Lys Leu Asp Leu Val  Leu Lys Glu Gly Val  Cys His Thr 
    1055                 1060                 1065             


Glu Glu  Glu Gln Lys Ala Tyr  Arg Glu Tyr Gln Asn  Glu Lys Asn 
    1070                 1075                 1080             


Arg Ile  Glu Leu Phe Asp Val  Cys Thr Tyr Thr Gln  Ile Leu Asn 
    1085                 1090                 1095             


Asp Met  Gln Ala Arg Leu Ile  Gly Trp Ser Tyr Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Met Tyr Tyr Gln Leu  Gly Tyr Tyr Tyr Thr  Lys Leu Phe 
    1115                 1120                 1125             


Trp Thr  Asp Ser Ile Ser Glu  Glu Asp Ala Arg Arg  Arg Leu Val 
    1130                 1135                 1140             


Gly Asn  Leu Val Asn Val Glu  Asp Gly Ala Ile Leu  Tyr Gln Ile 
    1145                 1150                 1155             


Leu Ala  Phe Asn Ser Tyr Asn  Leu Pro Ile Ile Ala  Asn Lys Asn 
    1160                 1165                 1170             


Asn Thr  Val Thr Leu Leu Lys  Asp Glu Gly Ser Ile  Gly Gly Lys 
    1175                 1180                 1185             


Ala Ile  Thr Ala Phe Phe Lys  Asn Tyr Glu Asn Ala  Glu Met Ile 
    1190                 1195                 1200             


Tyr Glu  Glu Ala Leu Asp Leu  Phe Glu Asn Met Asp  Glu His Ala 
    1205                 1210                 1215             


Ala Ile  Ile Asn Thr Arg Asn  Tyr Ile Glu His Phe  Lys Tyr Phe 
    1220                 1225                 1230             


Ile Lys  Ser Asp Arg Ser Met  Met Asp Leu Tyr Ser  Glu Ile Tyr 
    1235                 1240                 1245             


Asp Arg  Phe Phe Arg His Asp  His Asn Arg Lys Lys  Asn Val Pro 
    1250                 1255                 1260             


Asp Ser  Leu Lys Asn Val Leu  Ala Asp Asn Phe Met  Ile Val Asp 
    1265                 1270                 1275             


Ile Asp  Met Glu Leu Gly Ser  Lys Lys Val Gly Glu  Lys Lys Lys 
    1280                 1285                 1290             


Gly Phe  Arg Glu His Lys Ala  Ala Arg Ile Glu Phe  Thr Asp Ser 
    1295                 1300                 1305             


Gly Ile  Arg Ser Thr Asp Met  Thr Tyr Thr Ile Lys  Pro Asp Ile 
    1310                 1315                 1320             


Lys Asp  Asn Lys Lys Asp Lys  Lys Val Leu Val Pro  Ala Arg Ser 
    1325                 1330                 1335             


Glu Val  Phe Leu Lys Gln Phe  Arg Lys Ile Leu Glu  Tyr Arg Ile 
    1340                 1345                 1350             


Gln Asp  Lys Ile Gln 
    1355             


<210>  683
<211>  1184
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  683

Met Arg Val Ser Lys Val Lys Val Leu Gly Asn Glu Glu Thr Lys Gly 
1               5                   10                  15      


Arg Ile Val Leu Met His Arg Ser Pro Val Lys Gly Gln Leu Ile Tyr 
            20                  25                  30          


Ser Glu Asp Ala Gly Lys Arg Asp Arg Thr Glu Asp Ile Ile Pro Glu 
        35                  40                  45              


Gln Lys Leu Glu Ser Phe His Leu Ser Ile Leu Asn Lys Thr Phe Leu 
    50                  55                  60                  


Arg Lys Glu Phe Phe Lys Lys Glu Leu Lys His Glu Ala Lys Lys Asn 
65                  70                  75                  80  


Gly Leu Lys Gly Asp Ala Glu Asp Lys Tyr Ile Ser Glu Lys Leu Lys 
                85                  90                  95      


Glu Tyr His Ser Leu Leu Gln Phe Ile Asp Asp Val Leu Ser Val Lys 
            100                 105                 110         


Tyr Asn Glu Asn Arg Lys Ala Ile Lys Phe Pro Glu Tyr Leu Thr Arg 
        115                 120                 125             


Glu Met Ile Glu Ile Phe Leu Asn His Lys Phe Arg Lys Glu Val Thr 
    130                 135                 140                 


Tyr Thr Asn Lys Asn Gly Ala Ser Val Ser Phe Leu Leu Ser Thr Leu 
145                 150                 155                 160 


Ile Leu Asn Ala Ile Glu Lys His Ser Val Ile Glu Met Gln Pro Phe 
                165                 170                 175     


Val Asp Trp Arg Asn Trp Phe Val Glu Thr Lys Ser Lys Phe Leu Lys 
            180                 185                 190         


Lys Ser Ile Ile Asn Asn Cys Ile Pro Thr Asn Gly Gly Pro Ile Ser 
        195                 200                 205             


Arg Arg Arg Glu Thr Leu Met Lys Trp Arg Asp Asp Tyr Phe Thr Asn 
    210                 215                 220                 


Ala Glu Ile Asp Leu Ala Arg Leu His Lys Lys Phe Gly Thr Asp Thr 
225                 230                 235                 240 


Leu Met Ala Ser Leu Arg Glu Val Pro Gln Thr Glu Lys Ser Gly Asn 
                245                 250                 255     


Glu Tyr His Arg Leu Leu Lys Ser Cys Leu Gln Ser His Gln Lys Lys 
            260                 265                 270         


Leu Phe Gly Lys Arg Ala Glu Gly Tyr Asp Ile Asn Arg Ala Asp Asn 
        275                 280                 285             


Gln Leu Tyr Val Tyr Asn Thr Glu Val Val Lys Tyr Met Glu His Tyr 
    290                 295                 300                 


Phe Pro Val Lys Ser Ser Lys Arg Arg Asn Ser Thr Ala Glu Ile Lys 
305                 310                 315                 320 


Tyr Tyr Leu Gln Thr Asp Thr Ile Lys Cys Cys Leu His His Gln Ile 
                325                 330                 335     


Ile Asn Ala Val Arg Gly Leu Ala Leu Arg Glu Gly Lys Phe Asn Leu 
            340                 345                 350         


His Gly Phe Asp Asp Lys Leu Ile Pro Asn Glu Arg Asn Val Ser Ser 
        355                 360                 365             


Ser Ile Leu Asn Glu Leu Lys Thr Ser Glu Gly Phe Val Leu Asn Met 
    370                 375                 380                 


Leu Gly Gly Cys Ala Phe Ala Ala Asn Cys Leu Arg Asn Ile Val Asp 
385                 390                 395                 400 


Ala Thr Gln Arg Ser Asp Leu Leu Gly Phe Arg Cys Phe Glu Val Ser 
                405                 410                 415     


Leu Lys Lys Gly Lys Ser Asn Ser Asp Leu Phe Ala Leu Phe Phe Gly 
            420                 425                 430         


Phe Gly Arg Glu Asp Met Asp Asp Asp Ser Glu Trp Glu Lys His Leu 
        435                 440                 445             


Tyr Ala Ala Arg Tyr Ser Val Ser Glu Ile Arg Asn Arg Val Ala His 
    450                 455                 460                 


Tyr His Lys Ser Ala Ile Glu Asn Ile Tyr Asn Ile Thr Asp Phe Glu 
465                 470                 475                 480 


Tyr Arg Glu Asn Ser Met Cys Ser Tyr Thr Asp Thr Lys Phe Thr Thr 
                485                 490                 495     


Ala Leu Gln Asn Glu Ile Tyr Asn Thr Pro Lys Ala Phe Ser Leu Gln 
            500                 505                 510         


Leu Met Thr Gly Lys Val Leu Glu Tyr Tyr Pro Lys Glu Lys Leu Val 
        515                 520                 525             


Ser Phe Phe Gln Lys Tyr Lys Phe Ser Leu Tyr Arg Ser Val Val Pro 
    530                 535                 540                 


Phe Ala Pro Gly Phe Lys Asn Ile Met Arg Thr Gly Val Asn Tyr Gln 
545                 550                 555                 560 


Asn Ala Thr Gln Asn Arg Leu Phe Tyr Asp Met Gly Leu Thr Ala Phe 
                565                 570                 575     


Gln Asp Lys Asp Arg Tyr Ile Asp Asp Val Glu Ala Trp Asn Ala Arg 
            580                 585                 590         


Tyr Phe Phe Met Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Arg Phe 
        595                 600                 605             


Thr Asn Asp Lys Asn Asp Leu Phe Arg Lys Thr Val Glu Gln Val Leu 
    610                 615                 620                 


Glu Val Asn Arg Ser His Met Glu Lys Val Gly Lys Asp Asp Arg Gln 
625                 630                 635                 640 


Ala Phe Gly Glu Val Arg Gln Met Arg Glu Asn Glu Thr Ala Asn Asp 
                645                 650                 655     


Tyr Met Ala Tyr Leu Gln Ser Ser Leu Arg Met Glu Lys Asn Lys Lys 
            660                 665                 670         


Glu Leu Glu Gly Asn Gly Ala Lys Arg Ile Asn Phe Glu Lys Phe Ile 
        675                 680                 685             


Leu Gln Met Phe Val Lys Gly Phe Asp Ser Phe Leu Lys Asp Gly Ala 
    690                 695                 700                 


Phe Glu Phe Val His Ser Pro Glu Asn Cys Leu Thr Gly Ser Thr Glu 
705                 710                 715                 720 


Lys Glu Arg Ala Lys Glu Arg Asn Ser Leu Cys Glu Glu Ile Gly Asn 
                725                 730                 735     


Tyr Val Arg Leu Val Ser Thr Val Ile Asp Pro Gly Lys Gly Ser His 
            740                 745                 750         


Val Ala Phe Tyr Val Phe Cys Lys Met Leu Asn Ser Val Tyr Leu Ser 
        755                 760                 765             


Asn Ile Arg Asn Glu Met Ile Lys Tyr His Lys Val Val Arg Thr Asp 
    770                 775                 780                 


Glu Leu Ala His Leu Ile Glu Ile Ile Glu Leu Cys Leu Leu Ser Ala 
785                 790                 795                 800 


Asp Ala Val Ser Gln Lys Thr Val Asn Ala Asp Lys Leu Ser His Phe 
                805                 810                 815     


Phe Ala Glu Gly Val Asn Val Asp Asp Asp Glu Asn Val Ile His Ala 
            820                 825                 830         


Ser Met Glu Thr Phe Arg Lys Tyr Gly Thr Arg Asp Leu Phe His Lys 
        835                 840                 845             


Leu Met Leu Gln Asp Asp Arg Phe Leu Val Ser Ser Asp Asp Tyr Arg 
    850                 855                 860                 


Glu Trp Glu Glu Met Lys Glu Lys Ile Glu Gly Lys Val Lys Gln Arg 
865                 870                 875                 880 


Glu Leu Leu His Ala Glu Trp Cys Glu Ala Lys Glu Lys Asp Lys Lys 
                885                 890                 895     


Ser Arg Lys Val Lys Ser Asn Ser Arg Thr Cys Phe Glu Lys Lys Phe 
            900                 905                 910         


Met Gly Ala Lys Ala Glu Glu Tyr Tyr Ser Leu Cys Lys Val Ile Asp 
        915                 920                 925             


Lys Tyr Asn Trp Leu Asp Asn Lys Leu His Leu Val His Leu Asn Lys 
    930                 935                 940                 


Leu His Asn Leu Val Ile Glu Ile Leu Gly Arg Met Val Gly Phe Thr 
945                 950                 955                 960 


Ala Leu Phe Glu Arg Asp Phe Gln Tyr Ile Cys Lys Ser Asp Ser Glu 
                965                 970                 975     


Tyr Glu Gln Leu Tyr Asn Leu Asp Phe Asn Met Gly Leu Pro Lys Phe 
            980                 985                 990         


Lys Asn Ser Ile Lys Gly Ser Gly  Lys Ala Lys Asn Ser  Thr Gln Asn 
        995                 1000                 1005             


Ile Asp  His Asn Ala Thr Gly  Ile Gly Asn Ser Ser  Asn Leu Leu 
    1010                 1015                 1020             


Lys Glu  Asn Ser Asn Gly Thr  His Tyr Cys Lys Asn  Leu Ser Gly 
    1025                 1030                 1035             


Asp Gly  Val Glu Asp Lys Leu  Lys Arg Leu Phe Leu  Tyr Asp Asp 
    1040                 1045                 1050             


Tyr Arg  Asn Val Arg Asn Phe  Val Ala His Phe Asn  Tyr Leu Thr 
    1055                 1060                 1065             


Arg Val  Glu Asp Asp Leu Gly  Gly Asn Asp Ala Val  Lys Leu Ser 
    1070                 1075                 1080             


Gly Thr  Arg Tyr Ser Leu Ile  Glu Leu Ile Asn Glu  Leu Arg Asn 
    1085                 1090                 1095             


Leu Leu  Lys Tyr Asp Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ser 
    1100                 1105                 1110             


Phe Ile  Asp Met Phe Glu Arg  His Gly Met His Val  Lys Met Lys 
    1115                 1120                 1125             


Leu Asn  His Asn His Lys Leu  Phe Val Asp Ser Ile  Ser Pro Arg 
    1130                 1135                 1140             


Lys Ile  Lys His Leu Gly Gly  Gly Tyr Lys Lys Arg  Gly Lys Asp 
    1145                 1150                 1155             


Asp Lys  Met Tyr Val Gln Thr  Thr Asn His Val Asp  Pro Leu Tyr 
    1160                 1165                 1170             


Cys Asp  Met Cys Arg Ala Leu  Leu Glu Met Lys 
    1175                 1180                 


<210>  684
<211>  1344
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  684

Met Lys Ile Ser Lys Glu Ser His Arg Lys Thr Gly Val Leu Ile Asn 
1               5                   10                  15      


Asn Ser Gly Ala Glu Gly Ile Leu Tyr Lys Asp Pro Leu Lys Ser Asn 
            20                  25                  30          


Glu Lys Ile Glu Asp Val Val Asn Ala Arg Ala Asn Ser Thr Lys Arg 
        35                  40                  45              


Leu Phe Asn Leu Phe Gly Thr Gly Glu Glu Ser Lys Asp Ile Ser Lys 
    50                  55                  60                  


Asn Ala Lys Glu Val Ala Lys Thr Val Asn Arg Ala Ile Gly Asn Leu 
65                  70                  75                  80  


Lys Ala Asn Lys Lys Phe Asn Lys Lys Glu Arg Ile Asn Ser Glu Leu 
                85                  90                  95      


Lys Val Asp Val Leu Ile Glu Glu Leu Lys Lys Cys Arg Asn Ser Phe 
            100                 105                 110         


Ser Ala Asp Glu Val Asn Glu Ala Leu Asp Arg Leu Leu Lys Lys Ser 
        115                 120                 125             


Phe Arg Val Ala Pro Tyr Lys Asp Ala Val Arg Leu Leu Leu Met Ser 
    130                 135                 140                 


Thr Leu Val Asn Lys Lys Ala Leu Ser Asn Glu Glu Lys Asp Lys Val 
145                 150                 155                 160 


Gln Asn Tyr Phe Ile Lys Lys Leu Val Ala Glu Tyr Asp Lys Thr Leu 
                165                 170                 175     


Ile Lys Lys Gln Ile Pro Lys Ala Leu Val Asn Gln Asn Met Val Ile 
            180                 185                 190         


Gln Pro Ser Ser Asn Asp Gly Thr Leu Val Ile Ala Glu Thr Asn Lys 
        195                 200                 205             


Ser Lys Glu Thr Lys Leu Thr Glu Lys Asp Ala Phe Arg Leu Phe Leu 
    210                 215                 220                 


Arg Asp Tyr Ala Thr Leu Asp Asp Lys Leu Arg His Glu Met Arg Leu 
225                 230                 235                 240 


Lys Leu Arg Arg Leu Val Asp Leu Tyr Phe Tyr Gly Glu Glu Ala Val 
                245                 250                 255     


Ile Lys Glu Asp Phe Asp Glu Trp Glu Ile His Glu Lys Arg Lys Ala 
            260                 265                 270         


Asp Thr Ala Leu Phe Val Asp Lys Ala Thr Lys Ile Lys Ala Leu Lys 
        275                 280                 285             


Asn Gly Val Lys Arg Glu Ile Leu Asp Val Asp Thr Thr Leu Asp Ala 
    290                 295                 300                 


Ile Arg Gly Lys Asn Ile Ser Cys Tyr Arg Lys Ser Val Ser Ile Val 
305                 310                 315                 320 


Lys Asn Asn Asn Thr Gly Tyr Phe Asp Ser Glu Ala Leu Asn Lys Phe 
                325                 330                 335     


Trp Ile His His Ile Glu Asn Glu Val Glu Arg Ile Tyr Gly His Leu 
            340                 345                 350         


Lys Asn Asp Thr Gly Asn Tyr Lys Phe Gln Leu Gly Tyr Leu Ser Glu 
        355                 360                 365             


Lys Val Trp Lys Gly Ile Ile Asn Tyr Leu Ser Ile Lys Tyr Ile Ala 
    370                 375                 380                 


Glu Gly Lys Ala Val Tyr His Tyr Ala Met Lys Ala Leu Ser Ser Asp 
385                 390                 395                 400 


Asp Thr Thr Lys Thr Phe Gly Lys Val Asp Glu Lys Tyr Leu Lys Gly 
                405                 410                 415     


Ile Ser Ser Phe Glu Tyr Glu Arg Ile Lys Ala Glu Glu Thr Leu Gln 
            420                 425                 430         


Arg Glu Cys Ala Val Asn Val Ala Phe Ala Ala Asn His Leu Ala Asn 
        435                 440                 445             


Ala Thr Val Gln Leu Asp Glu Asn Asn Thr Asp Phe Leu Leu Leu Lys 
    450                 455                 460                 


Asn Lys Glu Pro Gln Glu Asp Ser Lys Lys Lys Gly Thr Lys Ser Leu 
465                 470                 475                 480 


Ala Glu Cys Ala Ser Ala Lys Pro Asn Thr Leu Arg Asn Ile Leu Gln 
                485                 490                 495     


Phe Phe Gly Gly Lys Ser Thr Trp Glu Asp Phe Asp Phe Ser Gly Tyr 
            500                 505                 510         


Asp Glu Ile Glu Leu Leu Asn Asp Met Lys Glu Met Ile Tyr Ser Leu 
        515                 520                 525             


Arg Asn Met Ser Phe His Phe Lys Thr Glu Asn Val Asn Glu Gly Lys 
    530                 535                 540                 


Trp Asn Thr Glu Leu Ile Gly Arg Met Phe Ala His Asp Cys Asp Arg 
545                 550                 555                 560 


Ala Ser Ile Val Gln Lys Asn Lys Leu Tyr Ser Asn Asn Ala Ala Met 
                565                 570                 575     


Phe Tyr Asn Ser Ser Asp Leu Ala Lys Leu Leu Asp Lys Leu Tyr Asn 
            580                 585                 590         


His Tyr Asn Glu Arg Ala Ser Gln Val Pro Ser Phe Asn Thr Val Phe 
        595                 600                 605             


Val Arg Lys Asn Phe Pro Glu Tyr Leu Lys Gln Gln Gln Ile Thr Pro 
    610                 615                 620                 


Ala Leu Ser Ala Glu Asp Thr Leu Lys Trp Gln Ser Thr Val Tyr Tyr 
625                 630                 635                 640 


Leu Tyr Lys Glu Ile Tyr Tyr Asn Ala Phe Leu Gln Asp Lys Glu Ser 
                645                 650                 655     


Phe Asn Leu Leu Lys Gln Tyr Val Arg Asn Leu Asp Glu His Cys Gln 
            660                 665                 670         


Asp Lys Asn Gln Ala Gly Ala Asn Arg Asp Phe Lys Ala Ala Phe Glu 
        675                 680                 685             


Ile Tyr Ser Glu Ser Gly Ser Met Ser Ala Thr Cys Gln Met Ile Met 
    690                 695                 700                 


Thr Glu Tyr Asn Asn Gln Asn Lys Gly Asn Arg Val Gly Ile Ser Gly 
705                 710                 715                 720 


Arg Thr Asn Ser Asp Asp Lys Leu Ile Phe Gln His Tyr Lys Met Ile 
                725                 730                 735     


Leu Phe Asp Gly Leu Lys Ala Ala Phe Phe Glu Tyr Leu Lys Lys Asn 
            740                 745                 750         


Gly Glu Val Tyr Asp Phe Ile Lys Thr Pro Lys Leu Val Thr Ile Leu 
        755                 760                 765             


Val Asp Ala Asp Val Phe Leu Gly Asp Tyr Lys Ser His Gln Tyr Asp 
    770                 775                 780                 


Ser Leu Val Glu Asn Val Lys Thr Asn Pro Glu Leu Gln Lys Trp Tyr 
785                 790                 795                 800 


Ile Thr Gly Arg Leu Leu Asn Pro Lys Gln Val Asn Gln Leu Ile Gly 
                805                 810                 815     


Thr Phe Arg Ser Tyr Val Gln Tyr Val Asn Asp Val Met Arg Arg Ala 
            820                 825                 830         


Lys Gln Val Lys Asn Pro Leu Thr Asp Glu Thr Ile Ser Ile Asp Val 
        835                 840                 845             


Asp Asn Ile Ile Lys Val Leu Asp Ile Cys Thr Lys Leu Asn Gly Ala 
    850                 855                 860                 


Thr Ser Asn Lys Ile Asp Asp Tyr Phe Asp Asn Gly Asp Glu Tyr Ala 
865                 870                 875                 880 


Lys Tyr Leu Gly Lys Phe Val Asp Phe Gly Leu Arg Asp Asp Val Asn 
                885                 890                 895     


Leu Ala Asn Ala Lys Leu Ala Gly Phe Cys Asp Gln Glu Val Asp Gly 
            900                 905                 910         


Gln Lys Ile Gly Ile Tyr His Asp Gly Thr Asn Pro Ile Leu Asn Arg 
        915                 920                 925             


Asn Val Val Leu Cys Lys Leu Tyr Gly Ala Ser Asp Val Val Ala Gln 
    930                 935                 940                 


Ala Gly Ile Leu Pro Val Asp Phe Glu Ile Ile Lys Lys Tyr Met Gln 
945                 950                 955                 960 


Leu Ser Gly Asn Ile Lys Glu Tyr Gln Leu Thr Gly Thr Cys Lys Thr 
                965                 970                 975     


Lys Ala Asp Gln Leu Lys Leu Lys Lys Tyr Gln Glu Leu Lys Asn Met 
            980                 985                 990         


Val Glu Leu Arg Asn Ile Val Asp  Tyr Ser Glu Leu Val  Asp Glu Leu 
        995                 1000                 1005             


Gln Gly  Gln Leu Ile Asn Trp  Gly Tyr Leu Arg Glu  Arg Asp Leu 
    1010                 1015                 1020             


Met Tyr  Phe Gln Leu Gly Phe  Asn Tyr Leu Ala Leu  Asn Asn Asp 
    1025                 1030                 1035             


Thr Gln  Lys Pro Glu Gly Tyr  Glu Lys Ala Gly Asp  Ile Asn Gly 
    1040                 1045                 1050             


Ala Ile  Leu Tyr Gln Ile Val  Ala Met Tyr Thr Asn  Gly Leu Ser 
    1055                 1060                 1065             


Leu Ile  Asp Ala Thr Gly Lys  Ser Lys Gly Asn Ala  Lys Ala Ser 
    1070                 1075                 1080             


Ala Gly  Ala Lys Ile Gly Ser  Phe Cys Ser Tyr Ser  Lys Ser Leu 
    1085                 1090                 1095             


Arg Asn  Val Pro Gly Asp Thr  Lys Glu Glu Ile Asp  Pro Ile Tyr 
    1100                 1105                 1110             


His Ala  Gly Leu Glu Leu Phe  Glu Asn Ile Asn Glu  His Asp Gln 
    1115                 1120                 1125             


Cys Val  Ala Leu Arg Asn Tyr  Ile Glu His Phe His  Tyr Tyr Ala 
    1130                 1135                 1140             


Lys Met  Asp Arg Ser Leu Leu  Asp Ile Tyr Ser Glu  Val Phe Asp 
    1145                 1150                 1155             


Arg Phe  Phe Thr Tyr Asp Met  Lys Tyr Ala Lys Asn  Val Pro Asn 
    1160                 1165                 1170             


Met Leu  Tyr Asn Ile Leu Leu  Gln His Leu Val Val  Pro Ser Phe 
    1175                 1180                 1185             


Glu Phe  Asn Ser Gly Glu Lys  Lys Leu Gly Asp His  Asn Ser Leu 
    1190                 1195                 1200             


Ser Lys  Lys Arg Ala Thr Ile  Ser Leu Lys Ser Glu  Asn Gly Leu 
    1205                 1210                 1215             


Ala Ser  Glu Lys Phe Thr Tyr  Lys Ile Gly Asp Lys  Lys Asn Pro 
    1220                 1225                 1230             


Ile Lys  Leu Ser Ala Arg Ser  Asn Asp Tyr Leu Ser  Asp Val Ala 
    1235                 1240                 1245             


Ala Ile  Leu Tyr Tyr Pro Asp  Lys Ala Pro Thr Gly  Val Val Arg 
    1250                 1255                 1260             


Asp Thr  Val Lys Glu Asp Asn  Ser Ala Lys Glu Gln  Gly Lys Lys 
    1265                 1270                 1275             


Ser Lys  Asp Phe Ala Gly Pro  Arg Asn Asn Lys Asn  Asn Asn Tyr 
    1280                 1285                 1290             


His Gly  His Asn Asn Gly Tyr  Asn Asn Gln Lys Arg  Asp Tyr Ser 
    1295                 1300                 1305             


Lys Gln  Asn Glu Asn Glu Tyr  Ser Gly Ser Leu Ser  Thr Gly Leu 
    1310                 1315                 1320             


Phe Asp  Ala Ala Asn Tyr Lys  Lys Asp Arg His Asn  Asn Asn Gln 
    1325                 1330                 1335             


Asn Tyr  Lys Lys Arg Lys 
    1340                 


<210>  685
<211>  1357
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  685

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Pro Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Lys Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Asp Ile Gln Arg Ile Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Lys Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Thr Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Ile Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Ile Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Gln Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Lys 
                405                 410                 415     


Arg Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Ile Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Ala Leu Glu Gly Glu Ser 
    450                 455                 460                 


Val Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Glu Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Ala Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Lys Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Lys Asp Asp Glu Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Ser Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Lys Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Ala Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Val Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Glu Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Asp 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Leu Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Lys Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Val Leu Val Pro Ala  Arg Ser Glu 
    1325                 1330                 1335             


Val Phe  Leu Lys Gln Phe Arg  Lys Ile Leu Glu Tyr  Arg Ile Gln 
    1340                 1345                 1350             


Asp Lys  Thr Gln 
    1355         


<210>  686
<211>  913
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  686

Met Lys Glu Leu Ile Glu Lys Val Pro Asn Val Ser Glu Leu Lys Lys 
1               5                   10                  15      


Ser Gln Val Phe Tyr Lys Tyr Tyr Leu Asn Lys Glu Lys Leu Asn Asp 
            20                  25                  30          


Glu Asn Ile Lys Tyr Val Phe Cys His Phe Val Glu Ile Glu Met Ser 
        35                  40                  45              


Lys Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn 
    50                  55                  60                  


Asp Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile 
65                  70                  75                  80  


Glu Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Ile Arg Asn Cys Gly 
                85                  90                  95      


Lys Tyr Ser Phe Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe 
            100                 105                 110         


Ile Val Gly Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly 
        115                 120                 125             


Val Ser Ser Ala Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu 
    130                 135                 140                 


Asn Glu Asn Asp Ile Thr Gly Lys Met Arg Gly Lys Thr Val Lys Asn 
145                 150                 155                 160 


Lys Lys Gly Glu Glu Lys Tyr Ile Ser Gly Glu Ile Asp Lys Leu Tyr 
                165                 170                 175     


Asp Asn Asn Lys Gln Asn Glu Val Lys Lys Asn Leu Lys Met Phe Tyr 
            180                 185                 190         


Ser Tyr Asp Phe Asn Met Asn Ser Lys Lys Glu Ile Glu Asp Phe Phe 
        195                 200                 205             


Ser Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His 
    210                 215                 220                 


Phe Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Thr Phe Lys Asn Ile 
225                 230                 235                 240 


Val Pro Ser Gln Ile Ser Lys Lys Met Phe His Asp Glu Ile Asn Glu 
                245                 250                 255     


Lys Lys Leu Lys Leu Lys Ile Phe Lys Gln Leu Asn Ser Ala Asn Val 
            260                 265                 270         


Phe Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Asn Arg Thr 
        275                 280                 285             


Arg Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr 
    290                 295                 300                 


Lys Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Cys Ile Tyr 
305                 310                 315                 320 


Trp Lys Ile Pro Lys Ala Asn Asp Asn Asn Lys Thr Lys Glu Ile Thr 
                325                 330                 335     


Asp Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Ser Glu Phe Leu 
            340                 345                 350         


Asn Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ile Lys Glu 
        355                 360                 365             


Ile Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe 
    370                 375                 380                 


Tyr Lys Leu Gln Lys Phe Glu Asn Leu Gln Glu Lys Thr Pro Lys Glu 
385                 390                 395                 400 


Tyr Leu Ala Asn Ile Gln Ser Phe Tyr Met Ile Asp Ala Gly Asn Lys 
                405                 410                 415     


Asp Glu Glu Glu Lys Asp Ala Tyr Ile Asp Phe Ile Gln Lys Ile Phe 
            420                 425                 430         


Leu Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu 
        435                 440                 445             


Met Tyr Ile Gly Asn Asp Glu Gln Ile Asn Thr Ser Leu Ala Glu Lys 
    450                 455                 460                 


Lys Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn 
465                 470                 475                 480 


Ile Lys Ile Pro Tyr Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu 
                485                 490                 495     


Gly Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile 
            500                 505                 510         


Leu Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu 
        515                 520                 525             


Glu Lys Tyr Gln Ser Ala Asn Lys Glu Glu Ala Phe Ser Asp Gln Leu 
    530                 535                 540                 


Glu Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp 
545                 550                 555                 560 


Phe Glu Leu Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly 
                565                 570                 575     


Asn Lys Val Lys Asp Asn Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys 
            580                 585                 590         


Ile Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn 
        595                 600                 605             


Ile Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu 
    610                 615                 620                 


Ala Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys 
625                 630                 635                 640 


Lys Asn Glu Ile Glu Lys Asn His Thr Asn Gln Glu Asn Leu His Arg 
                645                 650                 655     


Lys Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Asn Asp Glu Asp Tyr 
            660                 665                 670         


Lys Lys Tyr Glu Lys Ala Ile Arg Asn Ile Gln Gln Tyr Thr His Leu 
        675                 680                 685             


Lys Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Ser Leu Leu 
    690                 695                 700                 


Leu Arg Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg 
705                 710                 715                 720 


Asp Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile 
                725                 730                 735     


Glu Glu Ile Phe Asn Phe Asn Asn Ser Lys Asn Val Lys Tyr Lys Asn 
            740                 745                 750         


Gly Gln Ile Val Glu Lys Tyr Ile Ser Phe Tyr Lys Glu Leu Tyr Lys 
        755                 760                 765             


Asp Asp Thr Glu Lys Ile Ser Ile Tyr Ser Asp Lys Lys Val Lys Glu 
    770                 775                 780                 


Leu Lys Lys Glu Lys Lys Asp Leu Tyr Ile Arg Asn Tyr Ile Ala His 
785                 790                 795                 800 


Phe Asn Tyr Ile Pro Asn Ala Glu Ile Ser Leu Leu Glu Val Leu Glu 
                805                 810                 815     


Asn Leu Arg Lys Leu Leu Ser Tyr Asp Arg Lys Leu Lys Asn Ala Ile 
            820                 825                 830         


Met Lys Ser Ile Val Asp Ile Leu Lys Glu Tyr Gly Phe Val Val Thr 
        835                 840                 845             


Phe Lys Ile Glu Lys Asp Lys Lys Ile Arg Ile Glu Ser Leu Lys Ser 
    850                 855                 860                 


Glu Glu Val Val His Leu Lys Lys Leu Lys Leu Lys Asp Asn Asp Lys 
865                 870                 875                 880 


Lys Lys Glu Pro Ile Lys Thr Tyr Arg Asn Ser Lys Glu Leu Cys Glu 
                885                 890                 895     


Leu Val Lys Val Met Phe Glu Tyr Lys Met Lys Glu Lys Lys Ser Glu 
            900                 905                 910         


Asn 
    


<210>  687
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  687

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  688
<211>  1391
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  688

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Lys Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Phe Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn Gln Ile Gln Thr Gly Thr Lys Pro Lys Glu Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Lys Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Ile Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Asn Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Val Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Phe Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Gln Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Glu Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Ala Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Lys Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Ser Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Leu Tyr Leu Gln Asn Asn Lys Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Met Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Cys Ile  Ser Ser Ile Lys Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Thr Leu Ile Thr Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Gly  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Gly Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Asn Lys Asn Lys Lys  Asn Lys Lys Asn Asn  Gly Asn Arg 
    1355                 1360                 1365             


Asp Glu  Lys Lys Asn Ser Asp  Gly Leu Thr Tyr Ser  Pro Phe Leu 
    1370                 1375                 1380             


Asp Leu  Pro Phe Glu Leu Pro  Glu 
    1385                 1390     


<210>  689
<211>  1204
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  689

Met Lys Val Thr Lys Ile Asp Gly Ile Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Arg Tyr Thr Gly Asn Phe Asn Ile Lys Asn Glu 
            20                  25                  30          


Met Lys Glu Arg Leu Glu Lys Leu Lys Glu Leu Lys Leu Ser Asn Tyr 
        35                  40                  45              


Ile Lys Asn Pro Glu Asn Val Lys Asn Lys Asp Lys Asn Lys Glu Lys 
    50                  55                  60                  


Glu Thr Lys Ser Arg Arg Glu Asn Leu Lys Lys Tyr Phe Ser Glu Ile 
65                  70                  75                  80  


Ile Leu Arg Lys Lys Glu Glu Lys Tyr Leu Leu Lys Lys Thr Arg Lys 
                85                  90                  95      


Phe Lys Asn Ile Thr Glu Glu Ile Asn Tyr Asp Asp Ile Lys Lys Arg 
            100                 105                 110         


Glu Asn Gln Gln Lys Ile Phe Asp Val Leu Lys Glu Leu Leu Glu Gln 
        115                 120                 125             


Arg Ile Asn Glu Asn Asp Lys Glu Glu Ile Leu Asn Phe Asp Ser Val 
    130                 135                 140                 


Lys Leu Lys Glu Ala Phe Gly Glu Asp Phe Ile Lys Lys Glu Ser Lys 
145                 150                 155                 160 


Ile Lys Ala Ile Glu Glu Ser Leu Glu Lys Asn Arg Ala Asp Tyr Arg 
                165                 170                 175     


Lys Gly Phe Val Glu Leu Glu Asn Gly Lys Tyr Glu Asp Val Lys Gly 
            180                 185                 190         


Gln Asn Lys Arg Ser Leu Val Phe Glu Tyr Tyr Lys Asn Pro Glu Asn 
        195                 200                 205             


Arg Glu Lys Phe Lys Glu Asn Ile Lys Tyr Ala Phe Glu Asn Leu Tyr 
    210                 215                 220                 


Ile Glu Glu Asn Ile Lys Asn Leu Tyr Ser Glu Ile Glu Glu Ile Phe 
225                 230                 235                 240 


Glu Lys Val His Leu Lys Ser Lys Val Arg Asp Phe Tyr Gln Asn Gly 
                245                 250                 255     


Ile Ile Gly Glu Ser Glu Phe Ser Glu Lys Asp Glu Glu Gly Ile Ser 
            260                 265                 270         


Ile Leu Tyr Lys Gln Ile Ile Asn Ser Val Glu Lys Lys Glu Lys Phe 
        275                 280                 285             


Val Glu Phe Leu Gln Lys Val Lys Ile Lys Asp Leu Thr Arg Ser Gln 
    290                 295                 300                 


Ile Phe Tyr Lys Tyr Phe Leu Glu Asn Glu Glu Leu Asn Asp Glu Asn 
305                 310                 315                 320 


Ile Lys Tyr Val Phe Ser Tyr Phe Val Glu Ile Glu Val Asn Lys Leu 
                325                 330                 335     


Leu Lys Glu Asn Val Tyr Lys Thr Lys Lys Phe Asn Glu Gly Asn Lys 
            340                 345                 350         


Tyr Arg Val Lys Asn Ile Phe Asn Tyr Asp Lys Leu Lys Asn Leu Val 
        355                 360                 365             


Val Tyr Lys Leu Glu Asn Lys Leu Asn Asn Tyr Ile Arg Asn Cys Gly 
    370                 375                 380                 


Lys Tyr Asn Tyr His Met Glu Asn Gly Cys Val Ala Thr Ser Asp Thr 
385                 390                 395                 400 


Asn Met Lys Asn Arg Gln Thr Glu Ala Phe Leu Arg Ser Ile Leu Gly 
                405                 410                 415     


Val Ser Ser Phe Gly Tyr Phe Ser Leu Arg Asn Ile Leu Gly Val Asn 
            420                 425                 430         


Asp Asn Asp Phe Tyr Glu Met Glu Glu Glu Leu Thr Glu Asp Glu Arg 
        435                 440                 445             


Lys Asn Glu Asn Phe Ile Leu Lys Lys Ala Lys Glu Asp Ile Thr Ser 
    450                 455                 460                 


Lys Asn Ile Phe Glu Lys Val Val Asp Lys Ser Phe Glu Lys Lys Gly 
465                 470                 475                 480 


Ile Tyr Gln Ile Lys Glu Asn Leu Lys Met Phe Tyr Gly Asn Ser Phe 
                485                 490                 495     


Asp Lys Val Asp Lys Asp Glu Leu Lys Lys Phe Phe Val Asn Met Leu 
            500                 505                 510         


Glu Ala Ile Thr Ser Val Arg His Arg Ile Val His Tyr Asn Ile Asn 
        515                 520                 525             


Thr Asn Ser Glu Asn Ile Phe Asp Phe Ser Asn Ile Glu Val Ser Lys 
    530                 535                 540                 


Leu Leu Lys Asn Ile Phe Glu Lys Glu Ile Asp Thr Arg Glu Leu Lys 
545                 550                 555                 560 


Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Gly Val Phe Asp Tyr Trp 
                565                 570                 575     


Glu Ser Trp Val Ile Lys Lys Tyr Leu Glu Asn Val Lys Phe Glu Phe 
            580                 585                 590         


Val Asn Lys Asn Val Pro Phe Val Pro Ser Phe Lys Lys Leu Tyr Asp 
        595                 600                 605             


Arg Ile Asp Asn Leu Lys Gly Trp Asn Ala Leu Lys Leu Gly Asn Asn 
    610                 615                 620                 


Ile Asn Ile Pro Lys Arg Lys Glu Ala Lys Asp Ser Gln Ile Tyr Leu 
625                 630                 635                 640 


Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Val Glu Lys Phe Val Asn Asp 
                645                 650                 655     


Asn Lys Asn Phe Glu Lys Ile Val Lys Glu Ile Ile Glu Ile Asn Arg 
            660                 665                 670         


Gly Ala Gly Thr Asn Lys Lys Thr Gly Phe Tyr Lys Leu Glu Lys Phe 
        675                 680                 685             


Glu Thr Leu Lys Ala Asn Thr Pro Ile Glu Tyr Leu Glu Glu Leu Gln 
    690                 695                 700                 


Ser Leu His Lys Ile Ser Tyr Asp Lys Glu Lys Ile Glu Glu Asp Lys 
705                 710                 715                 720 


Asp Ile Tyr Val Asp Phe Val Gln Lys Ile Phe Leu Lys Gly Phe Val 
                725                 730                 735     


Asn Tyr Leu Lys Lys Leu Asp Ser Leu Lys Ser Leu Asn Leu Leu Asn 
            740                 745                 750         


Leu Arg Lys Asp Glu Thr Ile Thr Asp Lys Lys Ser Val His Asp Glu 
        755                 760                 765             


Lys Leu Lys Leu Trp Glu Asn Ser Gly Ser Asn Leu Ser Lys Met Pro 
    770                 775                 780                 


Glu Glu Ile Tyr Glu Tyr Val Lys Lys Ile Lys Ile Ser Asn Ile Asn 
785                 790                 795                 800 


Tyr Asn Asp Arg Met Ser Ile Phe Tyr Leu Leu Leu Lys Leu Ile Asp 
                805                 810                 815     


Tyr Arg Glu Leu Thr Asn Leu Arg Gly Asn Leu Glu Lys Tyr Glu Ser 
            820                 825                 830         


Met Asn Lys Asn Glu Ile Tyr Ser Glu Glu Leu Thr Ile Ile Asn Leu 
        835                 840                 845             


Val Asn Leu Asp Asn Asn Lys Val Arg Thr Asn Phe Ser Leu Glu Ala 
    850                 855                 860                 


Glu Asp Ile Gly Lys Phe Leu Lys Ser Ser Ile Pro Ile Lys Asn Val 
865                 870                 875                 880 


Ala Gln Leu Asn Asn Phe Ser Lys Ile Phe Ala Asp Gly Glu Asn Val 
                885                 890                 895     


Ile Lys His Arg Ser Phe Tyr Asn Ile Lys Lys Tyr Gly Ile Leu Asp 
            900                 905                 910         


Leu Leu Glu Lys Ile Val Ala Lys Ala Asp Leu Lys Ile Ala Lys Glu 
        915                 920                 925             


Glu Ile Lys Lys Tyr Glu Asn Leu Gln Lys Glu Leu Glu Lys Asn Asp 
    930                 935                 940                 


Phe Tyr Lys Ile Gln Glu Lys Ile His Arg Lys Tyr Asn Gln Lys Pro 
945                 950                 955                 960 


Asn Leu Ile Leu Arg Thr Glu Asn Lys Lys Asp Phe Asn Asp Tyr Lys 
                965                 970                 975     


Lys Ala Ile Glu Asn Ile Gln Asn Tyr Thr Gln Leu Lys Asn Lys Ile 
            980                 985                 990         


Glu Phe Asn Asp Leu Asn Leu Leu  Gln Ser Leu Leu Phe  Arg Ile Leu 
        995                 1000                 1005             


His Arg  Leu Ala Gly Tyr Thr  Ser Leu Trp Glu Arg  Asp Leu Gln 
    1010                 1015                 1020             


Phe Lys  Leu Lys Gly Glu Phe  Pro Glu Asp Lys Tyr  Ile Asp Glu 
    1025                 1030                 1035             


Ile Phe  Asn Phe Asp Asn Ser  Lys Asn Lys Ile Tyr  Asn Glu Lys 
    1040                 1045                 1050             


Asn Lys  Arg Gly Gly Ser Ile  Val Ser Lys Tyr Gly  Tyr Phe Leu 
    1055                 1060                 1065             


Ala Glu  Lys Asp Gly Glu Ile  Gln Glu Ser Arg Ala  Arg Asp Lys 
    1070                 1075                 1080             


Lys Lys  Lys Lys Ile Ile Lys  Lys Glu Gly Leu Glu  Ile Arg Asn 
    1085                 1090                 1095             


Tyr Ile  Ala His Phe Asn Tyr  Ile Pro Asp Ala Glu  Lys Ser Ile 
    1100                 1105                 1110             


Leu Glu  Met Leu Glu Glu Leu  Arg Glu Leu Leu Lys  Tyr Asp Arg 
    1115                 1120                 1125             


Lys Leu  Lys Asn Ala Val Met  Lys Ser Ile Lys Asp  Ile Phe Lys 
    1130                 1135                 1140             


Glu Tyr  Gly Phe Ile Val Glu  Phe Thr Ile Ser His  Thr Lys Asn 
    1145                 1150                 1155             


Gly Lys  Lys Ile Lys Val Cys  Ser Val Lys Ser Glu  Lys Ile Lys 
    1160                 1165                 1170             


His Leu  Lys Asn Asn Glu Leu  Ile Thr Thr Arg Asn  Ser Glu Asp 
    1175                 1180                 1185             


Leu Cys  Glu Leu Val Lys Ile  Met Leu Glu Tyr Lys  Glu Leu Gln 
    1190                 1195                 1200             


Lys 
    


<210>  690
<211>  1287
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  690

Met Arg Ile Gly Lys Val Gln Gly Arg Thr Phe Thr Gly Phe Asp Asn 
1               5                   10                  15      


Ala Arg Gly Lys Thr Leu Arg Arg Arg Leu Leu Thr Arg Pro Asp Asn 
            20                  25                  30          


Glu Ala Arg Ser Leu Ser Glu His Leu Ala His Asp Pro Lys Ala Leu 
        35                  40                  45              


Ile Gly Gln Ala Ile Ser Arg Ile Asp Thr Ile Tyr Gln Lys Pro Lys 
    50                  55                  60                  


Thr Gly Lys Pro Thr Pro Glu Gln Phe Gly His Arg Asp Thr Leu Gly 
65                  70                  75                  80  


Trp Ala Tyr Trp Lys Leu Leu Val Ala Ser Tyr Pro Glu Val Glu Gly 
                85                  90                  95      


His Arg Asp Leu Phe Val Arg Arg Leu His Pro Tyr Gly Asp Thr Pro 
            100                 105                 110         


Pro Lys Ser His Gly Gln Lys Glu Gly Glu His Gln Lys Gly Gly Lys 
        115                 120                 125             


Pro Gln Leu Glu Gly Arg Trp His Gly Val Met Ala Gln His Gly Lys 
    130                 135                 140                 


Asn Pro Asp Gln Ile Ala Ala Arg Leu Phe Asp His Leu His Asn Ser 
145                 150                 155                 160 


Glu Leu Arg Phe Gly Gly Thr Ala Ser Gly Glu Pro Arg Thr Arg Pro 
                165                 170                 175     


Gly Lys Glu Ala Thr Pro Thr Gly Leu Ile Gly Ala Arg Ala Lys Thr 
            180                 185                 190         


Ile Glu His Ser Val Leu Pro Arg Asp Ala Lys Arg Phe Val Ala Glu 
        195                 200                 205             


Trp Arg Gly Glu Asp Gln Glu Arg Tyr Ala Gly Ala Arg Asp Ile Ala 
    210                 215                 220                 


Ala Ala Ile Ser Ala Gly Leu Asn Asp Lys Asp Gln Lys Ser Gly Ser 
225                 230                 235                 240 


Gly Arg Lys Ser Ala Val Ile Gly Lys Leu Leu Ser Asp His Leu Glu 
                245                 250                 255     


Thr Leu Thr Gly Asn Arg Lys Cys Arg Phe Asp Pro Lys Ser Thr Ala 
            260                 265                 270         


Glu Thr Leu Glu Leu Arg Asp Gly Glu Ser Val Asp Asp Arg Arg Arg 
        275                 280                 285             


Ile Leu Glu Leu His Ala Glu Val Lys Ala Thr Tyr Lys Arg Met Ala 
    290                 295                 300                 


Ala Trp Lys Pro Ala Lys Leu Pro Arg Asn Ser Asp Glu Leu Phe Arg 
305                 310                 315                 320 


Leu Val Arg Gln Gln Ala Asp Asn Arg Ile Leu Asn His Leu Val Arg 
                325                 330                 335     


Val Gly Arg Ile Ser Val Tyr Ser Glu Gln Ser Asp Ala Leu Ser Glu 
            340                 345                 350         


Ser Gln Phe Trp Thr Ser Gly Gly Gln Thr Gln Ile Lys Glu Ser Glu 
        355                 360                 365             


Val Phe Ala Arg Leu Trp Ile Gly Ala Ile Ser Arg Ala Ser Tyr Ser 
    370                 375                 380                 


Met Lys Ala Trp Leu Glu Pro Glu Gly Thr Val Phe Asn Pro Ser Ile 
385                 390                 395                 400 


Asn Asp Phe Asp Val Thr Ser Ser His Asn Thr Asn Arg Ile Leu Glu 
                405                 410                 415     


Asp Ser Gly Arg Leu Ser Asn Ala Met Ala Arg Arg Ala Ile Tyr Phe 
            420                 425                 430         


Gly Glu Thr Pro Glu Phe Asp Ala Leu Gly Glu Glu Asp Gln Arg Val 
        435                 440                 445             


Leu Val Lys Lys Cys Leu Asp Ala Leu Ser Ala Cys Arg Asn Arg Thr 
    450                 455                 460                 


Phe His His Gly Gln Arg Ala Lys Phe Leu Lys Glu Val Arg Lys Gly 
465                 470                 475                 480 


Leu Lys Glu Lys Glu Ala Asp Ser Ala Gly Pro Ala Ala Trp Glu Gly 
                485                 490                 495     


Ile Arg Glu Val Ile Gln Ala Asp Ala Arg Asn Leu Gly Ala Arg Leu 
            500                 505                 510         


Leu Gln Asp Leu Thr Gly Ala Lys Val His Ser Phe Ala Thr Asp Pro 
        515                 520                 525             


Glu Phe Arg His Leu Tyr Glu Ser Val Ala Ala Thr Leu Thr Ala Gly 
    530                 535                 540                 


Gly Glu Leu Glu Ala Ala Leu Pro Arg Leu Lys Asn Val Leu Lys Arg 
545                 550                 555                 560 


Ala Glu Gly Val Arg Cys Tyr Leu Asp Thr Pro Ser Gln Arg Arg Glu 
                565                 570                 575     


Gly Asp Glu Ser Leu Ile Ala Arg Leu Pro Val Ala Pro Val Pro Arg 
            580                 585                 590         


Glu Leu Asp Asp Ala Ala Thr Lys Ala Arg His Ser Ala Leu Leu Arg 
        595                 600                 605             


Leu Tyr Asp Gly Pro Phe Arg Pro Trp Ala Thr Glu Leu Arg Gly Glu 
    610                 615                 620                 


Arg Leu Ser Asp Tyr Ala Ala Arg Ala Lys Arg Leu Ala Thr Arg Leu 
625                 630                 635                 640 


Ala Lys Ser Thr Asn Thr Ala Ser Pro Tyr Pro Asp Ser Val Glu Gly 
                645                 650                 655     


Arg Ser Val Arg Leu Arg Asp Pro Ile Thr Ala Asp Thr Ala Pro Glu 
            660                 665                 670         


Thr Leu Lys Thr Tyr Leu Ser Ala Leu Thr Ala Glu Thr Ala Thr Glu 
        675                 680                 685             


Phe Arg Val Gln Lys Gly Tyr Glu Ser Asp Gly Glu Lys Ala Lys Glu 
    690                 695                 700                 


Gln Ala Glu Phe Ile Glu Asp Phe Arg Arg Asp Met Ile Ala Leu Ala 
705                 710                 715                 720 


Phe Gln Asp Phe Ile Arg Asp His Gly Phe Ala Trp Leu Leu Asp Ile 
                725                 730                 735     


Ala Ser Lys Ala Glu Pro Ser Asn Asp Ala Pro Asn Leu Pro Asp Pro 
            740                 745                 750         


Val Asp Thr Gly Lys Asp Thr Val Phe Glu Asp Trp Gln Ala Leu Leu 
        755                 760                 765             


Tyr Leu Phe Leu His Phe Val Pro Ala Asp Asp Val Ser Gln Leu Leu 
    770                 775                 780                 


His Gln Leu Arg Lys Trp Asp Ala Leu Gln Asp Lys Tyr Glu Leu Ala 
785                 790                 795                 800 


Glu Pro Gly Glu Thr Leu Gly Gln Thr Lys Ala Asp Thr Arg Lys Ile 
                805                 810                 815     


Val Gly Gln Phe Arg Asp Cys Leu Thr Leu Phe Leu Lys Thr Gly Asp 
            820                 825                 830         


Ala Arg Phe Asp Gly Glu Gly Val Glu Leu Pro Leu Ser Asp Phe Gln 
        835                 840                 845             


Glu Leu Phe Glu Ser Pro Ala Thr Phe Lys Glu Leu Phe Leu Ala Glu 
    850                 855                 860                 


Pro Ala Glu Asn Asp Ala Ser Glu Thr Asp Asp Gln Asp Ala Pro Gly 
865                 870                 875                 880 


Glu Lys His Arg Val Thr Arg Thr Arg Arg Gly Leu Arg Gln Ile Leu 
                885                 890                 895     


Arg Tyr Asn His Met Pro Val Leu Arg Asp Leu Phe Leu Ala His Lys 
            900                 905                 910         


Val Thr Asp Ala Glu Val Asp Gly Leu Gln Ala Leu Glu Val Asp Asp 
        915                 920                 925             


Pro Gln Thr Gly Glu Ser Gln Ile Gly Ala Ala Gln Arg Ile Arg Thr 
    930                 935                 940                 


Glu Ile His His His Thr Ser Asn Asp Lys Gln Ile Ser Glu Ala Lys 
945                 950                 955                 960 


Val Glu Glu Tyr Arg Arg Ala Leu Ser Thr Ile Glu Arg His Arg Phe 
                965                 970                 975     


Leu Val Gly Arg Val Tyr Leu Gly Asp His Ile Arg Val His Lys Leu 
            980                 985                 990         


Met Met Asp Val Met Gly Arg Leu  Val Asp Phe Ala Gly  Ala Trp Glu 
        995                 1000                 1005             


Arg Glu  Ala Ala Asp Gly Asp  Arg Lys Gly Phe Ile  Ser Arg Ala 
    1010                 1015                 1020             


Ile Ala  Leu Pro Glu Val Ala  Glu Gly Tyr Ala Ala  Asp Arg Leu 
    1025                 1030                 1035             


Lys Thr  Val Ala Arg Arg Val  Leu Asp Asp Gly Glu  Ala Arg Arg 
    1040                 1045                 1050             


Ile Arg  Asn Asp Leu Gly His  Phe Asn Asp Leu Ala  Pro Thr Ser 
    1055                 1060                 1065             


Gly Pro  Ala Asn Leu Thr Phe  Val Val Asn Arg Ala  Arg Arg Met 
    1070                 1075                 1080             


Met Arg  His Asp Arg Lys Arg  Lys Asn Ala Val Thr  Lys Ser Val 
    1085                 1090                 1095             


Ile Glu  Ile Leu Asn Arg Gln  Gly Leu Gly Ile Glu  Trp Thr Met 
    1100                 1105                 1110             


Arg Asn  His Glu Leu Cys Glu  Ala Lys Leu Trp Gln  Asn Pro Val 
    1115                 1120                 1125             


Lys His  Leu Gly Phe Ala Thr  Leu Glu Gly Arg Gly  Lys Lys Trp 
    1130                 1135                 1140             


Arg Arg  Pro Phe Glu Ala Arg  Tyr Gly Asp Ala Tyr  Met Ala Met 
    1145                 1150                 1155             


Val Ala  Gln Leu Phe Asp Gly  Thr Val Thr Ser Pro  Pro Ala Lys 
    1160                 1165                 1170             


Gly Pro  Pro Gln Ser Gly Lys  Ser Gly Gly Lys Pro  Gly Lys Gly 
    1175                 1180                 1185             


Ala Glu  Gly Gly Ala Lys Glu  Lys Ser Arg Ser Pro  Thr Arg Met 
    1190                 1195                 1200             


Glu Glu  Gly Gly Val Tyr Glu  Gly Arg Val Ala Lys  Ala Lys Ser 
    1205                 1210                 1215             


Asp Lys  Gly Phe Gly Phe Leu  Leu Val Glu Gly Ala  Gln Glu Glu 
    1220                 1225                 1230             


Ile Phe  Leu His Ile Tyr Gly  Ile Ser Gly Asn Arg  Pro Ala Arg 
    1235                 1240                 1245             


Ile Glu  Asn Gly Gln Arg Tyr  Arg Phe Thr Leu Gly  Ile Asp Arg 
    1250                 1255                 1260             


Asp Arg  Glu Arg Arg Lys Glu  Arg Ala Trp Val Ala  Arg Glu Ala 
    1265                 1270                 1275             


Val Arg  Ile Asp Glu Asn Arg  Ser Lys 
    1280                 1285         


<210>  691
<211>  1373
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  691

Met Ala Lys His Leu Arg Pro Ile Gly Glu Ser Tyr Thr Asp Phe Leu 
1               5                   10                  15      


Asp Glu Thr Glu Phe Val Arg Leu Gly Arg Gly Leu His Arg Gly His 
            20                  25                  30          


His Gly Val Gln Ile Pro Pro Thr Glu Leu Pro Ser Tyr Leu Ala Glu 
        35                  40                  45              


Tyr Arg Lys Ala Leu Met Arg Gln Val Val Ala Val Leu Asp Lys Val 
    50                  55                  60                  


Val Gly Lys Arg Arg Arg Leu Ser Gly Met His Pro Glu Ala Tyr Arg 
65                  70                  75                  80  


Asp Arg Val His Leu Ala Glu Ala Leu Trp Val Arg Leu Val Ala Arg 
                85                  90                  95      


Val Lys Glu Ile Gly Thr Pro Pro Asp Pro Ser Glu Leu Leu Asp Leu 
            100                 105                 110         


Arg Arg Met Trp Asn Ala Lys Ala His Pro Tyr Ala Glu Tyr Asp Val 
        115                 120                 125             


Val Pro Arg Ala Pro Leu Asn Asp Gly Asn Gly Gln Lys Ile Leu Glu 
    130                 135                 140                 


Cys Arg Glu Val Asp Asp Pro Lys Ile Glu Arg Ser Asp Phe Glu Gly 
145                 150                 155                 160 


Arg Trp His Gly Arg Phe Trp Gln Ser Glu Pro Gly Pro Val Asp Tyr 
                165                 170                 175     


Asn Ala Ile Ala Asp Arg Ile Phe Ala His Leu Phe Asp Gln Glu Ala 
            180                 185                 190         


Val Ile Gly Gly Gly Pro Arg Arg Glu Gly Asn Val Thr Val Pro Asp 
        195                 200                 205             


Glu Asp Ile Asn Gly Gln Pro Gly Pro Ala Thr Gly Lys Gly Leu Ile 
    210                 215                 220                 


Ile Ala Arg Gly Gln Ser Ile Val Lys Ser Ala Ser Asp Pro Arg Arg 
225                 230                 235                 240 


Ser Ser Lys Lys Val Gln Arg Thr Trp Asp Lys Ala Val Glu Arg Arg 
                245                 250                 255     


Tyr Phe Gly Asp Asp Gly Lys Gly Gly Ser Asp Ile Ala Lys Ala Ile 
            260                 265                 270         


Tyr Glu Glu Leu Gly Asp Pro Ala Thr Leu Ala Asp Pro Ile Tyr Ala 
        275                 280                 285             


Ser Trp Phe Gly Ser Arg Leu Tyr Asp His Phe Gly Ser Phe Lys Asn 
    290                 295                 300                 


Ser Leu Pro Leu Glu Leu Lys Asp Pro Phe Lys Glu Gln Ile Trp Ala 
305                 310                 315                 320 


Leu His Asn Ser Val Arg Gln Phe Tyr Gln Arg Met Ala Lys Ser Asp 
                325                 330                 335     


Arg Phe Arg Leu Ala Leu Gln Asn Ala Arg Ser Glu Val Pro Asp Arg 
            340                 345                 350         


Ser Glu Leu Leu Ala Leu Leu Pro Lys Asp His Asp His Leu Leu Leu 
        355                 360                 365             


Val Leu Gly Gly Lys Lys Lys Asn Ala Glu Met Ser Glu Leu Ile Arg 
    370                 375                 380                 


Leu Gly Lys Leu Phe Val His Ala Ser Asp Val Leu His Asp Phe Asp 
385                 390                 395                 400 


Ala Asn Asp Ala Ala Ala Leu Asp Ala Phe Lys Arg Arg Met Ser Phe 
                405                 410                 415     


Leu Ala Thr Ser Ile Gly Gln Ser Glu Ile Lys Gln Thr Glu Thr Phe 
            420                 425                 430         


Ala Arg Thr Trp Arg Gly Ala Val Gly Leu Thr Leu Arg Thr Val Lys 
        435                 440                 445             


Gly Leu Ala Asp Pro Arg Gly Ile Ile Gly Thr Pro Asp Asn Arg Asp 
    450                 455                 460                 


Leu Gly Thr Ala Gly Pro Met Lys Asp Ala Phe Asn Lys Phe Asp Gln 
465                 470                 475                 480 


Pro His Phe Gln Gln His Met Thr Ile Ile Phe Gly Asn Lys Glu Leu 
                485                 490                 495     


Gln Ala Glu Gly Asn Pro Thr Arg Ser Ser Val Phe Thr Ala Asn Gly 
            500                 505                 510         


Asp Lys Asp His Gln Ala Glu Leu Leu Trp Gly Phe Leu Cys Val Val 
        515                 520                 525             


Arg Ser Val Arg Asn Arg Thr Asn His Tyr Asn Val Arg Arg Ala Leu 
    530                 535                 540                 


Leu Arg Leu Leu Asp Glu Gly Ile Val Ser Pro Met Pro Ser Asp Pro 
545                 550                 555                 560 


Lys Lys Glu Arg Val Glu Asn Arg Asn Leu Cys Thr Val Ser Pro Thr 
                565                 570                 575     


Ala Leu Glu Ala Phe Arg Arg Leu Leu Asn Phe Asp Leu Ala Ile Gln 
            580                 585                 590         


Lys Glu Ala Val Arg Thr Ala Leu Glu Gln Ala Lys Ala Ser Glu Phe 
        595                 600                 605             


Val Glu Glu Gly Lys Leu Arg Gly Leu Val Ser Glu Leu Ala Gly Thr 
    610                 615                 620                 


Glu Asp Met Pro Ala Leu His Ile Pro Arg Phe Ser Ala Val Met Asp 
625                 630                 635                 640 


Lys Val Arg Arg Leu Ala Asp Asn Arg Asp Val Gly Leu Asp Pro Ile 
                645                 650                 655     


Leu Ser Thr Leu Gln Arg Ser Leu Pro Pro Thr Asp Lys Gln Ala Glu 
            660                 665                 670         


Ser Asp Ala Ala Arg Cys Arg Tyr Arg Leu Leu Leu Glu Leu Tyr Lys 
        675                 680                 685             


Ser Gly Phe Arg Ser Trp Phe Ser Gly Ile Gln Ser Asn Glu Glu Asn 
    690                 695                 700                 


Asn Arg Glu Ile Cys His Trp Ala Val Lys Gln Val Gly Arg Ala Lys 
705                 710                 715                 720 


Asp Ala Arg Lys Ser Glu Tyr Asp Lys Lys Thr Lys Arg His Tyr Arg 
                725                 730                 735     


Ser Pro Asn Ser Leu Ile Asp Asp Leu Gly Leu Asp Lys Phe Asp Asp 
            740                 745                 750         


Leu Thr Asp Leu Leu Glu Ala Leu Ala Ser Gln Ser Thr Arg Glu His 
        755                 760                 765             


Asp Gln Asn Leu Lys Tyr Val Pro Asp Ala Arg Val Gln Ser Gln Met 
    770                 775                 780                 


Ser Asn Arg Ile Glu Glu Phe Arg Gln Glu Leu Phe Ala His Ile Phe 
785                 790                 795                 800 


Thr Lys Tyr Leu Asp Thr His Asp Phe Gly Trp Ile Gly Ala Ile Glu 
                805                 810                 815     


Val Arg Arg Glu Ala Cys Asp Leu Ala Asp Val Val Ser Ala Phe Glu 
            820                 825                 830         


Val Arg Asp Gln Lys Phe Asp Ala Asp Trp His Ser Gln Phe Tyr Ala 
        835                 840                 845             


Trp Leu Tyr Met Val Pro Pro Ile Glu Ala Ser Arg Leu Arg His Gln 
    850                 855                 860                 


Met Arg Lys Ser Ala Val Met Asp Asp Lys Trp Ser Thr Thr Leu Glu 
865                 870                 875                 880 


Leu Thr Ser Gly Asp Arg Lys Thr Arg Asp Asp His Ala Gln Asp Val 
                885                 890                 895     


Leu Ala Asp Met Asp Arg Leu Phe Ser Leu Tyr Thr Lys Val Gln Ala 
            900                 905                 910         


Ala Gly Phe Asn Gly Gln Glu His Glu Ser Ala Leu Gly Ser Lys Ser 
        915                 920                 925             


Leu Phe Tyr Glu Asp Gly Asn Gln Phe Asp Glu Val Tyr Ser Pro Asp 
    930                 935                 940                 


Thr Glu Thr His Asn Lys Thr Phe Pro Gly Thr Arg Arg Gly Leu Arg 
945                 950                 955                 960 


Gln Leu Val Arg Tyr Ala His Leu Pro Ala Leu Glu Gly Val Phe Lys 
                965                 970                 975     


Lys His Arg Ile Thr Lys Ala Glu Val Glu Thr Phe Val Ala Leu Tyr 
            980                 985                 990         


Asp Glu Asn Arg Arg Asp Pro Gly  Ser Val Ala His Met  Leu Arg Arg 
        995                 1000                 1005             


Glu Lys  Leu Arg Thr Glu Ile  Leu Arg Ser Ile His  Asp Gly Pro 
    1010                 1015                 1020             


Lys Pro  Lys Asp Lys Asp Phe  Trp Pro Lys Leu Glu  Ala Lys Cys 
    1025                 1030                 1035             


Leu Glu  Tyr Arg Thr Val Ala  Thr Glu Thr Ala Ile  Tyr Asn Phe 
    1040                 1045                 1050             


Gln Ala  Asn Ala Ala Arg Leu  Asn Asp His Ala Arg  Leu His Gln 
    1055                 1060                 1065             


Ile Val  Met Arg Val Val Ala  Arg Leu Thr Asp Tyr  Ala Leu Ile 
    1070                 1075                 1080             


Trp Glu  Arg Asp Arg Leu Phe  Ala Phe Val Gly Met  Leu Tyr Arg 
    1085                 1090                 1095             


Gln Thr  Gly Gly Thr Gly Ile  Asn Pro Ala Met Arg  His Ala Glu 
    1100                 1105                 1110             


Lys Thr  Asn Ala Pro Pro Arg  Ile Gly Ile Leu Val  Ser Asp Ser 
    1115                 1120                 1125             


Ala Leu  Ala Lys Lys Leu Asn  Ser Asn Ser Ala Glu  Val Phe Ile 
    1130                 1135                 1140             


Pro Tyr  Leu Asp Thr Glu Thr  Gly Phe Asp Ala Pro  Arg Phe Asp 
    1145                 1150                 1155             


Asp Leu  Cys Thr Leu Leu Ser  His Glu His Ala Lys  Glu Phe Arg 
    1160                 1165                 1170             


Phe His  Phe Leu Glu Val Gly  Glu Glu Asn Ser Lys  Asp Glu Ala 
    1175                 1180                 1185             


Arg Arg  Leu Asn Glu Glu Thr  Met Gly His Arg Lys  Arg Pro Ala 
    1190                 1195                 1200             


Phe Lys  Arg Gly Thr Arg Arg  Gln Gly Ile Arg Asn  Asp Leu Ala 
    1205                 1210                 1215             


His His  Asn Val Leu Asp Leu  Ala Gly Gly Ala Gly  Pro Asn Leu 
    1220                 1225                 1230             


Thr Tyr  Val Val Asn Ala Val  Arg Ser Leu Leu Ser  Tyr Asp Arg 
    1235                 1240                 1245             


Lys Leu  Lys Asn Ala Val Pro  Lys Ser Ile Lys Arg  Ile Leu Gly 
    1250                 1255                 1260             


Glu Glu  Gly Leu Ile Ile Glu  Trp Gln Met Asn Tyr  Asp Arg Leu 
    1265                 1270                 1275             


Lys Lys  Pro Thr Val Tyr Pro  Asn Val Glu Thr His  Leu Thr Met 
    1280                 1285                 1290             


Val Pro  Pro Arg His Met Thr  Ala Pro Val Ser Phe  Thr Leu Pro 
    1295                 1300                 1305             


Arg Ala  Ser Val Arg Leu Ala  Ser Met Val Lys Ala  Val Phe Asp 
    1310                 1315                 1320             


Phe Gly  Ser Ser Gly Tyr Gly  Glu Glu Arg Met Ile  Gly Gly Arg 
    1325                 1330                 1335             


Thr Ala  Lys Gln Ala Val Tyr  Pro Asp Asp Phe Thr  Arg Arg Phe 
    1340                 1345                 1350             


Pro Gln  Thr Pro Met Gly Leu  Lys Gln Ala Thr Arg  Leu Val Phe 
    1355                 1360                 1365             


Ala Ser  Glu Asn Ser 
    1370             


<210>  692
<211>  1432
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  692

Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser Val Thr 
1               5                   10                  15      


Glu Asn Lys Asn Glu Glu Gln Leu Ser Arg Gln Ser Leu Leu Tyr Tyr 
            20                  25                  30          


Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp Leu Glu 
        35                  40                  45              


Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr Asn Val 
    50                  55                  60                  


Ile Thr Pro Glu Ile Asp Leu Cys Lys Glu Glu Asn Arg Glu Trp Ile 
65                  70                  75                  80  


Val Glu Asp Leu Thr Lys Asn Phe Asn Ala Val Ile Asn Asn Ala Leu 
                85                  90                  95      


Arg Ser Ile Lys Asn Pro Lys Glu Lys Arg Glu Glu Arg Val Glu Lys 
            100                 105                 110         


Glu Val Ala Phe Ile Leu Asn Leu Asn Lys Asn Ser Ile Lys Ile Lys 
        115                 120                 125             


Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe Ser Ala 
    130                 135                 140                 


Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser Lys Glu 
145                 150                 155                 160 


Glu Ala Tyr Ile Arg Glu Met Ile Ser Asn Leu Val Leu Arg Lys Leu 
                165                 170                 175     


Lys Lys Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Cys Lys Met 
            180                 185                 190         


Gln Met Thr Glu Ile Thr Ile Ser Leu Met Ser Ala Ile Cys Leu Tyr 
        195                 200                 205             


Gly Asn Val Glu Ser Phe Asp Pro Val Ile Leu Lys Ala Phe Phe Glu 
    210                 215                 220                 


Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile Val 
225                 230                 235                 240 


Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys Asp 
                245                 250                 255     


Gly Lys His Leu Leu Ile Pro Ala Asn Ala Asp His Arg Lys Lys Lys 
            260                 265                 270         


Tyr Val Phe Glu Phe Met Arg Lys Tyr Ala Ala Ala Glu Glu Lys Glu 
        275                 280                 285             


Lys Arg Glu Ile Thr Glu His Ile Gln Asn Leu Ile Gly Leu Tyr Leu 
    290                 295                 300                 


Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asn Met 
305                 310                 315                 320 


Thr Glu Ser His Asn Cys Ile Ser Gly Glu Ile Glu Glu Ile Phe Asn 
                325                 330                 335     


Glu Ile Glu Glu Leu Glu Asn Ser Ser Lys Gln Lys Arg Glu Glu Lys 
            340                 345                 350         


Lys Lys Thr Arg Glu Glu Leu Asp Lys Ile Gln Glu Ser Arg Lys Gly 
        355                 360                 365             


Asn Lys Arg Asn Thr Asn Ser Asn Asn Gln Asn Tyr Lys Asn Asn Lys 
    370                 375                 380                 


Thr Asp Ser Asp Lys Lys Glu Asn Gln Ala Asp Ala Asn Glu Asn Lys 
385                 390                 395                 400 


Leu Lys Glu Asn Glu Leu Arg Asp Lys Arg Arg Arg Leu Ser Lys Glu 
                405                 410                 415     


Leu Glu Asn Leu Asp Ser Glu Val Arg Ile Lys Lys Glu Lys Leu Lys 
            420                 425                 430         


Asn Thr Thr Val Lys Glu Met Ala Leu Lys Tyr Arg Ala Ala Val Asn 
        435                 440                 445             


Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile Lys Glu 
    450                 455                 460                 


Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr Ile Asp 
465                 470                 475                 480 


Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp Arg Tyr 
                485                 490                 495     


Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu Trp Thr 
            500                 505                 510         


Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val Tyr His 
        515                 520                 525             


Phe Ala Ile Pro Asp Leu Ser Gly Ala Leu Glu Gly Glu Ser Val Ser 
    530                 535                 540                 


Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly Phe Asp 
545                 550                 555                 560 


Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met Glu Lys 
                565                 570                 575     


Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr Pro Glu 
            580                 585                 590         


Glu Glu Arg Glu Lys Pro Gly His Glu Asp Val Leu Leu Met Lys Thr 
        595                 600                 605             


Leu Ser Glu Ile Glu Glu Ser Gln Thr Glu Glu Glu Arg Gln Lys Lys 
    610                 615                 620                 


His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp Ala Asp 
625                 630                 635                 640 


Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg Lys Lys 
                645                 650                 655     


Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr Lys Glu 
            660                 665                 670         


Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His Tyr Thr 
        675                 680                 685             


Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Glu Leu Thr Glu Tyr 
    690                 695                 700                 


Phe Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg Glu Lys 
705                 710                 715                 720 


Tyr Tyr Thr Asn Asn Val Trp Lys Tyr Tyr Asp Ile Glu Val Ile Asn 
                725                 730                 735     


Asn Ile Met Gly Lys Ile Tyr Cys Gly Arg Lys Tyr Arg Ala Ala Gln 
            740                 745                 750         


Val Pro Ala Phe Asn Asn Ile Ile Ser Arg Pro Ala Leu Pro Gln Leu 
        755                 760                 765             


Met Asp Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met Asn Cys 
    770                 775                 780                 


Pro Asp Arg Asp Val Ile Lys Lys Tyr Trp Ser Ser Leu Phe Phe Val 
785                 790                 795                 800 


Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Glu Lys Pro 
                805                 810                 815     


Glu Asp Asn Ile Lys Glu Arg Phe Phe Arg Ala Met Glu Lys Glu Ser 
            820                 825                 830         


Gly Gln Ala Lys Asp Gly Lys Glu Gln Lys Ala Trp Glu Ser Phe Glu 
        835                 840                 845             


Asn Arg Ile Asp Gln Ile Gly Arg Glu Arg Ser Phe Gly Ala Ile Cys 
    850                 855                 860                 


Gln Gly Leu Met Val Glu Tyr Met Leu Gln Asn Arg Asp Ile Ser Met 
865                 870                 875                 880 


Val Gln Thr Glu Thr Gly Asp Gly Lys Thr Asn Lys Lys Gln Ile Tyr 
                885                 890                 895     


Lys His Tyr Arg Thr Leu Leu Tyr Ile Cys Ile Arg Ser Ala Phe Thr 
            900                 905                 910         


Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro Val Leu Thr 
        915                 920                 925             


Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Gln Thr Asp Gly Leu Lys 
    930                 935                 940                 


His Leu Ser Leu Phe Asp His Leu Lys Glu Thr Phe Asn Asp Ala Glu 
945                 950                 955                 960 


Ser Gly Ser Phe Trp Tyr Met Ala Ala His Phe Ile Asn Gln Lys Tyr 
                965                 970                 975     


Leu Asn His Leu Ile Gly Ser Ile Arg Asn Tyr Leu Gln Phe Thr Glu 
            980                 985                 990         


Asp Ile Glu Asp Arg Ala Leu Ser  Leu Gly Asp Cys Val  Asp Asn Lys 
        995                 1000                 1005             


Arg Glu  Glu Lys Asn Leu Arg  Tyr Arg Asn Thr Leu  Glu Ile Leu 
    1010                 1015                 1020             


Glu Phe  Val Ala Gln Phe Cys  Glu Arg Thr Thr Asn  Val Met Glu 
    1025                 1030                 1035             


Asp Tyr  Phe Glu Ser Asn Gln  Glu Tyr Ala Ala Tyr  Leu Ser Gly 
    1040                 1045                 1050             


Phe Val  Asp Tyr Asn Val Ser  Lys Lys Glu Thr Asp  Ile Glu Lys 
    1055                 1060                 1065             


Ala Leu  Tyr Gly Phe Cys Arg  Gln Lys Phe Lys Val  Asp Gly Lys 
    1070                 1075                 1080             


Glu Tyr  Met Ala Gly Ile Tyr  Tyr Asp Gly Glu Asn  Leu Ile Pro 
    1085                 1090                 1095             


Asn Arg  Asn Ile Ile Arg Ala  Asn Met Tyr Gly Asn  Val Ser Cys 
    1100                 1105                 1110             


Leu Lys  Pro Tyr Met Asp Arg  Ile Thr Leu Lys Glu  Ile Arg Thr 
    1115                 1120                 1125             


Met Tyr  Ala Asp Gln Asn Lys  Leu Asp Thr Val Leu  Lys Glu Gly 
    1130                 1135                 1140             


Val Cys  Arg Thr Glu Glu Glu  Gln Lys Ala Tyr Arg  Glu Tyr Gln 
    1145                 1150                 1155             


Asn Glu  Lys Asn Arg Ile Glu  Leu Phe Asp Leu Cys  Thr Tyr Thr 
    1160                 1165                 1170             


Gln Ile  Leu Asn Asp Ile Gln  Ala Lys Leu Ile Gly  Trp Ser Tyr 
    1175                 1180                 1185             


Met Arg  Glu Arg Asp Leu Met  Tyr Tyr Gln Leu Gly  Tyr Tyr Tyr 
    1190                 1195                 1200             


Thr Lys  Leu Phe Trp Thr Asp  Ser Ile Ser Glu Glu  Asp Ala Arg 
    1205                 1210                 1215             


Arg Arg  Leu Met Gly Glu Leu  Val Asn Val Glu Asp  Gly Val Ile 
    1220                 1225                 1230             


Leu Tyr  Gln Ile Leu Ala Phe  Asn Ser Tyr Asn Leu  Pro Ile Ile 
    1235                 1240                 1245             


Ala Asn  Lys Asn Asn Thr Val  Thr Phe Leu Lys Gly  Glu Gly Ser 
    1250                 1255                 1260             


Ile Gly  Gly Lys Ala Ile Thr  Ala Phe Leu Lys Asn  Tyr Glu Asn 
    1265                 1270                 1275             


Ala Glu  Arg Ile Tyr Glu Glu  Ala Leu Asp Leu Phe  Glu Asn Thr 
    1280                 1285                 1290             


Asp Glu  His Ala Ala Ile Ile  Asn Thr Arg Asn Tyr  Ile Glu His 
    1295                 1300                 1305             


Phe Lys  Tyr Phe Ile Lys Ser  Asp Arg Ser Met Met  Asp Leu Tyr 
    1310                 1315                 1320             


Ser Glu  Val Tyr Asp Arg Phe  Phe Arg His Asp His  Asn Arg Lys 
    1325                 1330                 1335             


Lys Asn  Val Pro Asp Ser Leu  Lys Asn Val Leu Ala  Asp Asn Phe 
    1340                 1345                 1350             


Met Ile  Ala Asp Ile Ser Met  Glu Leu Gly Ser Lys  Lys Val Gly 
    1355                 1360                 1365             


Glu Lys  Lys Lys Gly Phe Arg  Glu His Lys Ala Ala  Arg Ile Glu 
    1370                 1375                 1380             


Phe Thr  Asp Arg Gly Ile Arg  Ser Thr Asp Met Thr  Tyr Thr Val 
    1385                 1390                 1395             


Lys Pro  Asp Pro Lys Asp Ser  Lys Lys Asp Glu Lys  Val Leu Val 
    1400                 1405                 1410             


Pro Ala  Arg Ser Glu Val Phe  Leu Lys Gln Phe Gln  Lys Ile Leu 
    1415                 1420                 1425             


Glu Tyr  Arg Ile 
    1430         


<210>  693
<211>  1165
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  693

Met Gly Ser Gly Lys Tyr Arg Ile Thr Lys Ile Ala Arg Lys Trp Asp 
1               5                   10                  15      


Lys Asn Glu Asn Trp Glu Lys Ile Ile Leu Lys Arg Ile Val Asp Asn 
            20                  25                  30          


Lys Lys Ile Lys Tyr Val Asn Glu Asn Asn Asn Lys Asp Val Asp Ile 
        35                  40                  45              


Thr Asp Thr Tyr Tyr Ser Ile Leu Ser Lys Asn Asn Ser Lys Phe Leu 
    50                  55                  60                  


Gly Ser Glu Glu Gln Phe Ile Phe Lys Val Asn Lys Met Lys Arg Asn 
65                  70                  75                  80  


Ile Lys Asn Asp Cys Val Ile Ile Lys Asp Tyr Thr Glu Glu Glu Phe 
                85                  90                  95      


Glu Lys Phe Asp Lys Lys Ile Phe Phe Ser Arg Lys Ile Lys Val Asn 
            100                 105                 110         


Asn Glu Asp Arg Glu Lys Ile Cys Arg Asn Phe Tyr Glu Asp Glu Arg 
        115                 120                 125             


Glu Ile Met Lys Lys Arg Leu Glu Glu Ala Lys Asn Phe Asn Asn Ile 
    130                 135                 140                 


Ile Phe Asn Ile Cys Asn Lys Ile Phe Lys Leu Glu Tyr Ile Asp Tyr 
145                 150                 155                 160 


Thr Asp Glu Lys Val Tyr Glu Ile Phe Gln Lys Glu Ile Lys Phe Glu 
                165                 170                 175     


Asp Ile Lys Asn Leu Lys Glu Ala Phe Lys Gln Gln Glu Asn Gly Leu 
            180                 185                 190         


Glu Thr Asp Lys Leu Leu Thr Ile Ser Phe Asn Lys Lys Arg Ser Asn 
        195                 200                 205             


Val Leu Leu Glu Phe Ile Gln Gln Ile Val Lys Gln Asn Phe Glu Asn 
    210                 215                 220                 


Glu Lys Glu Leu Glu Asn Trp Phe Ser His Asp Gly Glu Lys Tyr Cys 
225                 230                 235                 240 


Lys Glu Ile Phe Lys Ile Tyr Ser Asn Met Ser Gln Lys Glu Lys Tyr 
                245                 250                 255     


Ser Lys Leu Leu Gly His Asn Asp Lys Ser Ile Ala Ser Asn Ser Glu 
            260                 265                 270         


Lys Arg Glu Thr Leu Gln Arg Arg Leu Lys Leu Gly Asp Tyr Ser Lys 
        275                 280                 285             


Tyr Asp Leu Lys Lys Tyr Tyr Gln Lys Asp Tyr Lys Glu Glu Ala Ile 
    290                 295                 300                 


Lys Glu Leu Glu Asp Lys Ser Lys Glu Glu Leu Glu Lys Glu Val Glu 
305                 310                 315                 320 


Glu Ile Ile Lys Lys Asn Tyr Lys Ile Asp Lys Leu Cys Asp Glu Ile 
                325                 330                 335     


Ser Asn Leu Glu Phe Ser Phe Val Asp Ser Lys Lys Glu Asn Lys Asp 
            340                 345                 350         


Lys Met Ser Glu Ile Ile Val Lys Ile Lys Glu His Tyr Lys Asn Asn 
        355                 360                 365             


Val Asn Val Glu Glu Glu Leu Glu Asn Lys Glu Lys Tyr Ile Leu Ser 
    370                 375                 380                 


Val Ile His Asn Tyr Ile Lys Gly Arg Tyr Arg Lys Cys Leu Glu Leu 
385                 390                 395                 400 


Gln Gln Lys Glu Asn Val Asp Phe Glu Asn Leu Gly Lys Arg Ile Lys 
                405                 410                 415     


Glu Ile Phe Asp Ser Asn Lys Val Thr Glu Lys Leu Lys Lys Ser Ile 
            420                 425                 430         


Leu Asn Lys Val Asn Asn Tyr Lys Ile Phe Glu Thr Lys Phe Gln Asn 
        435                 440                 445             


Pro Asn Ile Glu Ser Ser Asp Asp Leu Glu Ile Leu Lys Ala Glu Glu 
    450                 455                 460                 


Thr Phe Leu Asn Lys Leu Ser Thr Ala Val Ser Lys Val Gly Tyr Ile 
465                 470                 475                 480 


Leu Asn Ile Leu Leu Glu Ile His Phe Arg Asn Asp Ile Leu Gln Asp 
                485                 490                 495     


Tyr Asn Gln Val Glu Lys Leu Trp Lys Ser Asp Ser Phe Gln Lys Ile 
            500                 505                 510         


Cys Ala Ile Tyr Pro Glu Ile Asn Asn Asp Glu Lys Leu Leu Lys Gly 
        515                 520                 525             


Met Ile Tyr Phe Ile Gln Gly Leu Arg Gln Gln Val Leu His Pro Lys 
    530                 535                 540                 


Ile Leu Trp Glu Lys Gln Asn Ile Tyr Asn Ala Glu Asn Ile Lys Glu 
545                 550                 555                 560 


Lys Glu Lys Ile Val Ser Val Arg Leu Gln Asn Glu Gly Glu Ala Tyr 
                565                 570                 575     


Asn Lys Lys Gly Ile Gln Asn Tyr Phe Glu Asn Val Leu Lys Lys Ile 
            580                 585                 590         


Pro Asp Tyr Phe Ile Glu Lys Tyr Glu Ser Ser Asn Val Phe Asn Ile 
        595                 600                 605             


Tyr Arg Asn Phe Val Asp Lys Ile Met Glu Val Val Lys Asn Phe Asn 
    610                 615                 620                 


Phe Lys Glu Asn Asn Thr Ile Asp Tyr Leu Phe Pro Lys Phe His Lys 
625                 630                 635                 640 


Ile Tyr Lys Arg Met Cys Lys Leu Glu Asn Ile Asp Asp Arg Gln Asn 
                645                 650                 655     


Gly Ala Arg Lys Tyr Leu Leu Gln Ile Ile Tyr Tyr Tyr Tyr Phe Gln 
            660                 665                 670         


Tyr Glu Ile Glu Asn Asp Lys Asn Asn Ile Ser Lys Tyr Leu Asn Leu 
        675                 680                 685             


Tyr Arg Asn Lys Ile Lys Val Lys Lys Ile Ser Tyr Ser Tyr Ile Thr 
    690                 695                 700                 


Asp Asn Lys Ala Val Asn Asn Lys Asn Ile Glu Ile Leu Tyr Arg Asn 
705                 710                 715                 720 


Ile Gln Arg Glu Gly Met Leu Asn Asn Lys Leu Ser Gln Met Asn Lys 
                725                 730                 735     


Glu Trp Ile Glu Phe Ile Val Val Gln Phe Ser Glu Phe Leu Thr Asn 
            740                 745                 750         


Lys Lys Leu Asn Trp Ile Leu Asp Asn Leu Ser Glu Tyr Lys Lys Lys 
        755                 760                 765             


Glu Lys Leu Asp Glu Asn Asp Lys Asn Arg Leu Leu Lys Ile Leu Lys 
    770                 775                 780                 


Gln Lys Met Asn Lys Lys Ile Ile Tyr Ser Asn Asp Ser Tyr Ala Phe 
785                 790                 795                 800 


Ile Ser Leu Ala Gln Phe Leu Asp Leu Lys Glu Ile Ser Asn Leu Ile 
                805                 810                 815     


His Asp Ile Lys Lys Phe Ile Gln Phe Arg Glu Lys Asn Val Ser Lys 
            820                 825                 830         


Tyr Lys Pro Glu Lys Asn Lys Leu Tyr Ile Lys Glu Leu Arg Lys Val 
        835                 840                 845             


Leu Tyr Ile Leu Lys Val Met Leu Glu His Lys Glu Arg Val Ile Gln 
    850                 855                 860                 


Lys His Tyr Leu Glu Ser Tyr Asp Glu Asn Ile Ser Ile Ile Tyr Gly 
865                 870                 875                 880 


Lys Asp Ile Glu Arg Lys Asp Ile Lys Asp Ile Lys Ile Lys Ile Lys 
                885                 890                 895     


Asn Glu Asn Gln Glu Ile Ile Asn Gln Pro Leu Tyr Lys Ser Gly Asn 
            900                 905                 910         


Asp Glu Asn Ser Ser Trp Ile Val Leu Tyr Gly Ile Glu Gln Ala Lys 
        915                 920                 925             


Arg Asn Gly Thr Phe Lys Phe Phe Glu Gly Phe Phe Asn Leu Asn Asp 
    930                 935                 940                 


Asp Ile Lys Leu Cys Lys Glu Asn Ile Glu Lys Tyr Glu Glu Leu Tyr 
945                 950                 955                 960 


Asn Glu Lys Glu Glu Asn Gln Arg Lys Val Asp Glu Tyr Ile Ser Ser 
                965                 970                 975     


Glu Glu Asn Asn Asn Ile Asp Glu Ile Lys Glu Ile Asn Asn Asn Lys 
            980                 985                 990         


Gln Leu Phe Tyr Tyr Tyr Lys Asn  Met Ile Tyr Gly Asp  Gly Leu Lys 
        995                 1000                 1005             


Lys Gly  Tyr Asp Phe Ile Asn  Asp Ile Tyr Ser His  Tyr Leu Ser 
    1010                 1015                 1020             


Trp Ala  Tyr Arg Val Glu Arg  Asp Cys Lys Ile Tyr  Lys Ile Lys 
    1025                 1030                 1035             


Glu Tyr  Glu Asn Lys Lys Asn  Phe Asn Glu Tyr Lys  Phe Lys Glu 
    1040                 1045                 1050             


Tyr Lys  Ser Ile Lys Asn Phe  Arg Asn Glu Ile Ala  His Phe Asn 
    1055                 1060                 1065             


Tyr Phe  Gln Lys Thr Asn Lys  Ser Leu Leu Glu Leu  Leu Asn Asp 
    1070                 1075                 1080             


Phe Tyr  Asp Ile Phe Asp Tyr  Asn Leu Lys Tyr Gln  Arg Asp Val 
    1085                 1090                 1095             


Gln Asn  Val Ile Asn Asn Ile  Phe Glu Lys Tyr Gln  Ile Val Arg 
    1100                 1105                 1110             


Lys Asp  Gly Gly Pro Val Val  Phe Tyr Cys Lys Thr  Asp Lys Lys 
    1115                 1120                 1125             


Leu Lys  Leu Ser Glu Asn Leu  Val Pro Lys Lys His  Ser Lys Tyr 
    1130                 1135                 1140             


Pro Glu  Ile Lys Leu Ile His  Glu Lys Tyr Val Met  Phe Phe Arg 
    1145                 1150                 1155             


Lys Leu  Phe Glu Tyr Lys Lys  
    1160                 1165 


<210>  694
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  694

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Ser Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Val Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Thr Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Lys Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Val Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Lys Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Lys Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Val Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Leu Lys Glu Leu Lys Glu Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn Tyr Arg Met Gln Gln Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Lys Lys Asp Glu Lys Phe Asn Asp Lys Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Thr Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Glu Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Lys  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  695
<211>  1385
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  695

Met Gly Asn Leu Phe Gly His Lys Arg Trp Tyr Glu Val Ser Asp Arg 
1               5                   10                  15      


Gly Asp Asn Lys Ile Lys Arg Lys Val Lys Val Lys Arg Asn Tyr Asp 
            20                  25                  30          


Gly Asn Lys Tyr Ile Leu Asn Ile Asn Glu Asn Asn Asn Lys Glu Lys 
        35                  40                  45              


Ile Asp Asn Asn Lys Phe Ile Arg Lys Tyr Ile Asn Tyr Lys Lys Asn 
    50                  55                  60                  


Asp Asn Ile Leu Lys Glu Phe Lys Arg Lys Phe His Ala Gly Asn Ile 
65                  70                  75                  80  


Leu Phe Lys Leu Lys Gly Lys Glu Lys Ile Lys Arg Ile Glu Asn Asn 
                85                  90                  95      


Asp Asp Phe Leu Glu Thr Glu Glu Val Val Leu Asp Lys Glu Val Tyr 
            100                 105                 110         


Gly Gln Ser Glu Lys Leu Lys Asn Glu Glu Gly Ile Thr Lys Gln Tyr 
        115                 120                 125             


Ile Leu Lys Asp Ile Ile Asn Lys Gly Ile Asp Lys Ser Asn Asp Lys 
    130                 135                 140                 


Ile Leu Val Lys Thr Lys Phe Gly Lys Glu Ile Thr Ile Asn Phe Thr 
145                 150                 155                 160 


Asp Glu Ala Lys Lys Asn Lys Asn Glu Tyr Gln Ile Thr Leu Lys Ile 
                165                 170                 175     


Ile Pro Glu Asn Glu Leu Lys Ile Lys Arg Glu Val Tyr Asp Val Phe 
            180                 185                 190         


Lys Ile Ile Asn Met Asp Leu Tyr Gln Ile Ile Lys Glu Ile Ile Glu 
        195                 200                 205             


Asn Glu Val Glu Lys Val Phe Lys Asn Arg Tyr Tyr Glu Glu Tyr Leu 
    210                 215                 220                 


Lys Glu Lys Leu Leu Glu Asp Asn Gln Ile Asn Val Ile Leu Thr Asn 
225                 230                 235                 240 


Phe Met Lys Ile Arg Glu Lys Ile Lys Ser Asn Pro Glu Ile Met Gly 
                245                 250                 255     


Phe Ile Lys Phe Tyr Leu Asn Val Asp Gly Asp Lys Lys Lys Ser Glu 
            260                 265                 270         


Asn Lys Lys Met Leu Val Glu Lys Ile Leu Asn Ile Asn Val Asp Leu 
        275                 280                 285             


Thr Val Glu Asp Ile Val Asp Phe Val Ile Lys Glu Leu Glu Phe Trp 
    290                 295                 300                 


Asn Ile Thr Lys Arg Ile Glu Lys Val Lys Glu Phe Asn Asn Lys Ser 
305                 310                 315                 320 


Leu Glu Asn Lys Arg Asn Ile Thr Tyr Ile Lys Ser Tyr Val Leu Leu 
                325                 330                 335     


Asp Lys His Glu Lys Phe Lys Ile Glu Arg Glu Asn Lys Lys Asp Lys 
            340                 345                 350         


Ile Val Lys Phe Phe Val Glu Asn Ile Lys Asn Asn Ser Ile Lys Glu 
        355                 360                 365             


Lys Ile Glu Lys Ile Leu Thr Glu Phe Lys Ile Asn Glu Leu Ile Lys 
    370                 375                 380                 


Lys Leu Glu Lys Glu Leu Lys Arg Gly Asn Cys Asp Thr Glu Ile Phe 
385                 390                 395                 400 


Gly Ile Phe Lys Lys His Tyr Lys Val Asn Phe Asp Ser Lys Lys Phe 
                405                 410                 415     


Ser Lys Lys Ser Asp Glu Glu Lys Glu Leu Tyr Lys Ile Ile Tyr Arg 
            420                 425                 430         


Tyr Leu Lys Gly Arg Ile Glu Lys Ile Leu Val Asn Glu Gln Lys Ala 
        435                 440                 445             


Arg Leu Lys Lys Met Glu Lys Ile Glu Ile Glu Lys Ile Leu Asn Glu 
    450                 455                 460                 


Ser Ile Leu Ser Glu Lys Ile Leu Lys Arg Val Lys Gln Tyr Thr Leu 
465                 470                 475                 480 


Glu His Ile Met Tyr Leu Gly Lys Leu Arg His Asn Asp Ile Val Lys 
                485                 490                 495     


Met Thr Val Asn Thr Asn Asp Phe Ser Ser Leu His Ala Lys Glu Glu 
            500                 505                 510         


Leu Asp Leu Glu Leu Ile Thr Phe Phe Ala Ser Thr Asn Val Glu Leu 
        515                 520                 525             


Asn Lys Ile Phe Glu Ile Asn Lys Glu Lys Asn Asp Phe Phe Gly Asp 
    530                 535                 540                 


Ser Phe Lys Ile Asn Asp Thr Lys Val Leu Leu Lys Asn Glu Val Thr 
545                 550                 555                 560 


Ser Ser Lys Leu Tyr Ile Leu Lys Asn Leu Asn Phe Ile Asp Asn Glu 
                565                 570                 575     


Asn Lys Val Lys Lys Glu Glu Phe Ile Ser Lys Phe Ile Thr Ile Gly 
            580                 585                 590         


Val Asn Glu Arg Asn Arg Ile Leu His Ala Asn Ser Lys Glu Ile Ala 
        595                 600                 605             


Pro Lys Gly Lys Gln Asp Asn Tyr Asp Lys Val Ile Asn Ile Ile Lys 
    610                 615                 620                 


Asn Leu Lys Ile Ser Asn Glu Glu Val Ser Lys Ala Leu Asn Leu Asp 
625                 630                 635                 640 


Val Val Phe Lys Asn Lys Lys Asp Ile Ile Thr Lys Ile Asn Asp Ile 
                645                 650                 655     


Lys Ile Ser Glu Glu Asn Ser Asn Asp Ile Lys Tyr Leu Pro Ser Phe 
            660                 665                 670         


Ser Lys Ile Leu Pro Glu Ile Leu Asn Leu Tyr Arg Asn Asn Pro Lys 
        675                 680                 685             


Asn Glu Pro Phe Asp Thr Ile Glu Thr Glu Lys Ile Ala Leu Asn Ala 
    690                 695                 700                 


Leu Ile Tyr Val Asn Lys Glu Leu Tyr Lys Lys Leu Ile Leu Glu Asp 
705                 710                 715                 720 


Asp Leu Glu Glu Asn Gly Ser Lys Asn Ile Phe Leu Gln Glu Leu Lys 
                725                 730                 735     


Lys Thr Leu Gly Asn Ile Asp Glu Ile Asp Glu Asn Ile Ile Glu Asn 
            740                 745                 750         


Tyr Tyr Lys Asn Ala Gln Ile Ser Ala Ser Lys Gly Asn Asn Lys Ala 
        755                 760                 765             


Ile Lys Lys Tyr Gln Lys Lys Ile Ile Glu Cys Tyr Ile Glu Tyr Leu 
    770                 775                 780                 


Arg Lys Asn Tyr Glu Lys Leu Phe Asp Phe Ser Asp Phe Lys Met Asn 
785                 790                 795                 800 


Ile Gln Glu Ile Lys Lys Gln Ile Lys Glu Ile Asn Asp Asn Lys Thr 
                805                 810                 815     


Tyr Lys Arg Ile Thr Ile Asn Thr Ser Asp Lys Ser Ile Val Ile Asn 
            820                 825                 830         


Asn Asp Phe Glu Tyr Ile Ile Ser Ile Phe Ala Leu Leu Asn Asn Asn 
        835                 840                 845             


Ile Val Ile Asn Lys Ile Arg Asn Arg Phe Phe Ala Thr Ser Val Trp 
    850                 855                 860                 


Leu Asn Thr Ser Glu Tyr Gln Asn Ile Ile Asn Ile Leu Asp Glu Ile 
865                 870                 875                 880 


Met Gln Ile Asn Ile Leu Lys Ser Glu Tyr Ile Thr Ser Asn Trp Lys 
                885                 890                 895     


Glu Asn Leu Glu Glu Phe Ile Arg Lys Thr Lys Asn Lys Glu Ile Glu 
            900                 905                 910         


Leu His Gln Ser Lys Lys Glu Phe Phe Asp Asn Asn Tyr Lys Glu Ile 
        915                 920                 925             


Lys Asn Asp Ile Val Asn Gly Phe Gln Asp Asn Glu Glu Ile Lys Lys 
    930                 935                 940                 


Ile Phe Asp Asn Asn Leu Lys Glu Ile Ile Asp Phe Arg Asn Asn Gly 
945                 950                 955                 960 


Thr Met Tyr Phe Lys Asn Leu Lys Glu Leu Ser Gln Ile Glu Arg Lys 
                965                 970                 975     


Phe Ile Leu Asp Asn Lys Lys Ile Phe Gly Asp Lys Ile Asp Glu Ile 
            980                 985                 990         


Ile Ile Lys Lys Gln Lys Glu Ile  Lys Glu Glu Ile Leu  Ser Lys Lys 
        995                 1000                 1005             


Ile Phe  Asn Ser Glu Phe Leu  Glu Lys Tyr Lys Glu  Ile Ile Asp 
    1010                 1015                 1020             


Asn Leu  Thr Lys Asn Glu Asn  Lys Phe Glu Lys Ile  Tyr Tyr Pro 
    1025                 1030                 1035             


Lys Glu  His Lys Asn Glu Leu  Tyr Ile Tyr Lys Lys  Asn Leu Phe 
    1040                 1045                 1050             


Leu Asn  Ile Gly Asn Pro Asn  Phe Asp Lys Ile Tyr  Gly Leu Ile 
    1055                 1060                 1065             


Ser Lys  Asp Ile Lys Asn Val  Asp Thr Lys Ile Leu  Phe Asp Asp 
    1070                 1075                 1080             


Asp Ile  Arg Lys Asn Lys Ile  Ser Glu Ile Asp Ala  Ile Leu Lys 
    1085                 1090                 1095             


Asn Leu  Asn Asp Lys Leu Asn  Gly Tyr Ser Asn Asp  Tyr Lys Ala 
    1100                 1105                 1110             


Lys Tyr  Val Asn Lys Leu Lys  Glu Asn Asp Asp Phe  Phe Ala Lys 
    1115                 1120                 1125             


Asn Ile  Gln Asn Glu Asn Tyr  Ser Ser Phe Gly Glu  Phe Glu Lys 
    1130                 1135                 1140             


Asp Tyr  Asn Lys Val Ser Glu  Tyr Lys Lys Ile Arg  Asp Leu Val 
    1145                 1150                 1155             


Glu Phe  Asn Tyr Leu Asn Lys  Ile Glu Ser Tyr Leu  Ile Asp Ile 
    1160                 1165                 1170             


Asn Trp  Lys Leu Ala Ile Gln  Met Ala Arg Phe Glu  Arg Asp Met 
    1175                 1180                 1185             


His Tyr  Ile Val Asn Gly Leu  Arg Glu Leu Gly Ile  Ile Lys Leu 
    1190                 1195                 1200             


Ser Gly  Tyr Asn Thr Gly Ile  Ser Arg Ala Tyr Pro  Lys Arg Asn 
    1205                 1210                 1215             


Gly Ser  Asp Gly Phe Tyr Thr  Thr Thr Ala Tyr Tyr  Lys Phe Phe 
    1220                 1225                 1230             


Asp Glu  Glu Ser Tyr Lys Lys  Phe Glu Lys Ile Cys  Tyr Gly Phe 
    1235                 1240                 1245             


Gly Ile  Asp Leu Ser Glu Asn  Ser Glu Ile Asn Lys  Pro Glu Asn 
    1250                 1255                 1260             


Glu Ser  Ile Arg Asn Tyr Ile  Ser His Phe Tyr Ile  Val Arg Asn 
    1265                 1270                 1275             


Pro Phe  Ile Asp Tyr Ser Ile  Ala Glu Gln Ile Asp  Arg Val Ser 
    1280                 1285                 1290             


Asn Leu  Leu Ser Tyr Ser Thr  Arg Tyr Asn Asn Ser  Thr Tyr Ala 
    1295                 1300                 1305             


Ser Val  Phe Glu Val Phe Lys  Lys Asp Val Asn Leu  Asp Tyr Asp 
    1310                 1315                 1320             


Lys Leu  Lys Thr Lys Phe Lys  Leu Phe Asp Asp Glu  Lys Asn Asp 
    1325                 1330                 1335             


Asp Ile  Lys Ile Leu Lys Ile  Glu Asp Leu Ile Glu  Ser Lys Lys 
    1340                 1345                 1350             


Val Ser  Val Leu Glu Leu Glu  Ser Tyr Asn Ser Asp  Tyr Val Lys 
    1355                 1360                 1365             


Asn Leu  Ile Ile Glu Leu Leu  Thr Lys Ile Glu Asn  Thr Asn Asp 
    1370                 1375                 1380             


Thr Leu  
    1385 


<210>  696
<211>  1162
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  696

Met Lys Val Thr Lys Val Gly Gly Ile Ser His Lys Lys Tyr Thr Ser 
1               5                   10                  15      


Glu Gly Arg Leu Val Lys Ser Glu Ser Glu Glu Asn Arg Thr Asp Glu 
            20                  25                  30          


Arg Leu Ser Ala Leu Leu Asn Met Arg Leu Asp Met Tyr Ile Lys Asn 
        35                  40                  45              


Pro Ser Asn Thr Glu Thr Lys Glu Thr Glu Lys Arg Ile Arg Lys Leu 
    50                  55                  60                  


Lys Lys Leu Phe Ser Asn Lys Met Val Tyr Leu Lys Asp Asn Thr Leu 
65                  70                  75                  80  


Lys Leu Lys Asn Gly Lys Lys Glu Asn Ser Asn Arg Glu Tyr Phe Glu 
                85                  90                  95      


Thr Asp Ile Leu Glu Ser Asp Val Arg Asp Lys Lys Asn Phe Ala Val 
            100                 105                 110         


Leu Lys Lys Ile Tyr Leu Asn Glu Asn Val Asn Ser Glu Glu Leu Glu 
        115                 120                 125             


Val Phe Arg Asn Asp Ile Lys Lys Lys Leu Asn Lys Ile Asn Ser Leu 
    130                 135                 140                 


Lys Tyr Ser Phe Glu Lys Asn Lys Ala Asn Tyr Gln Lys Ile Asn Glu 
145                 150                 155                 160 


Asn Asn Ile Glu Lys Val Glu Gly Lys Ser Lys Arg Asn Ile Ile Tyr 
                165                 170                 175     


Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn Asn Val 
            180                 185                 190         


Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu Lys Leu 
        195                 200                 205             


Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys Ile Arg 
    210                 215                 220                 


Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu Asn Phe 
225                 230                 235                 240 


Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile Lys Glu 
                245                 250                 255     


Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser Gln Val 
            260                 265                 270         


Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Glu Asn Val 
        275                 280                 285             


Lys Tyr Val Phe Cys His Phe Val Glu Ile Glu Met Ser Lys Leu Leu 
    290                 295                 300                 


Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp Lys Val 
305                 310                 315                 320 


Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu Asn Lys 
                325                 330                 335     


Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys Tyr Ser 
            340                 345                 350         


Phe Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile Val Gly 
        355                 360                 365             


Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val Ser Ser 
    370                 375                 380                 


Thr Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn Glu Asn 
385                 390                 395                 400 


Asp Ile Thr Gly Arg Ile Lys Gly Lys Thr Val Lys Asn Asn Lys Gly 
                405                 410                 415     


Glu Glu Lys Tyr Ile Ser Gly Glu Ile Asp Lys Leu Tyr Asp Asn Asn 
            420                 425                 430         


Lys Gln Asn Glu Val Lys Lys Asn Leu Lys Met Phe Tyr Ser Tyr Asp 
        435                 440                 445             


Phe Asn Met Asn Ser Lys Lys Glu Ile Glu Asp Phe Phe Ser Asn Ile 
    450                 455                 460                 


Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe Asn Leu 
465                 470                 475                 480 


Glu Leu Glu Gly Lys Asp Ile Phe Thr Phe Lys Asn Ile Val Pro Ser 
                485                 490                 495     


Gln Ile Ser Lys Lys Met Phe Gln Asp Glu Ile Asn Glu Lys Lys Leu 
            500                 505                 510         


Lys Leu Lys Ile Phe Lys Gln Leu Asn Ser Ala Asn Val Phe Asn Tyr 
        515                 520                 525             


Tyr Glu Lys Asp Val Ile Ile Lys Tyr Leu Lys Asn Thr Lys Leu Asn 
    530                 535                 540                 


Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys Leu Tyr 
545                 550                 555                 560 


Asn Lys Ile Glu Asp Leu Arg Asn Thr Leu Lys Phe Phe Trp Ser Val 
                565                 570                 575     


Pro Lys Asp Lys Glu Glu Lys Asp Ala Gln Ile Tyr Leu Leu Lys Asn 
            580                 585                 590         


Ile Tyr Tyr Gly Glu Phe Leu Asn Lys Phe Val Lys Asn Ser Lys Val 
        595                 600                 605             


Phe Phe Lys Ile Thr Asn Glu Val Ile Lys Ile Asn Lys Gln Arg Asn 
    610                 615                 620                 


Gln Lys Thr Gly His Tyr Lys Tyr Gln Lys Phe Glu Asn Ile Glu Lys 
625                 630                 635                 640 


Thr Val Pro Val Glu Tyr Leu Ala Ile Ile Gln Ser Arg Asp Met Ile 
                645                 650                 655     


Asn Asn Gln Asp Lys Glu Glu Lys Asn Thr Tyr Ile Asp Phe Ile Gln 
            660                 665                 670         


Gln Ile Phe Leu Lys Gly Phe Ile Asp Tyr Leu Asn Lys Asn Asn Leu 
        675                 680                 685             


Lys Tyr Ile Glu Asn Asn Asn Asn Asn Asp Asn Asn Asp Ile Phe Ser 
    690                 695                 700                 


Lys Ile Lys Ile Lys Lys Asp Asn Lys Glu Lys Tyr Asp Lys Ile Leu 
705                 710                 715                 720 


Lys Asn Tyr Glu Lys His Asn Arg Asn Lys Glu Ile Pro His Glu Ile 
                725                 730                 735     


Asn Glu Phe Val Arg Glu Ile Lys Leu Gly Lys Ile Leu Lys Tyr Thr 
            740                 745                 750         


Glu Ser Leu Asn Met Phe Tyr Leu Ile Leu Lys Leu Leu Asn His Lys 
        755                 760                 765             


Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu Lys Tyr Gln Ser Ala Asn 
    770                 775                 780                 


Lys Glu Glu Ala Phe Ser Asp Gln Leu Glu Leu Ile Asn Leu Leu Asn 
785                 790                 795                 800 


Leu Asp Asn Asn Arg Val Thr Glu Asp Phe Glu Leu Glu Ala Asp Glu 
                805                 810                 815     


Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn Lys Val Lys Asp Asn Lys 
            820                 825                 830         


Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile Tyr Phe Asp Gly Glu Asn 
        835                 840                 845             


Ile Ile Lys His Arg Ala Phe Tyr Asn Ile Lys Lys Tyr Gly Met Leu 
    850                 855                 860                 


Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala Lys Tyr Lys Ile Ser Ile 
865                 870                 875                 880 


Glu Glu Leu Lys Asn Tyr Ser Lys Lys Lys Asn Glu Ile Glu Glu Asn 
                885                 890                 895     


His Thr Thr Gln Glu Asn Leu His Arg Lys Tyr Ala Arg Pro Arg Lys 
            900                 905                 910         


Asp Glu Lys Phe Thr Asp Glu Asp Tyr Lys Lys Tyr Glu Lys Ala Ile 
        915                 920                 925             


Arg Asn Ile Lys Gln Tyr Thr His Leu Lys Asn Lys Val Glu Phe Asn 
    930                 935                 940                 


Glu Leu Asn Leu Leu Gln Ser Leu Leu Leu Arg Ile Leu His Arg Leu 
945                 950                 955                 960 


Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp Leu Arg Phe Arg Leu Lys 
                965                 970                 975     


Gly Glu Phe Pro Glu Asn Gln Tyr Ile Asp Glu Ile Phe Asn Phe Asp 
            980                 985                 990         


Asn Ser Lys Asn Val Lys Tyr Lys  Asn Gly Gln Ile Val  Glu Lys Tyr 
        995                 1000                 1005             


Ile Asn  Phe Tyr Lys Glu Leu  Tyr Lys Asp Asp Thr  Glu Lys Ile 
    1010                 1015                 1020             


Ser Ile  Tyr Ser Asp Lys Lys  Val Lys Glu Leu Lys  Lys Glu Lys 
    1025                 1030                 1035             


Lys Asp  Leu Tyr Ile Arg Asn  Tyr Ile Ala His Phe  Asn Tyr Ile 
    1040                 1045                 1050             


Pro Asn  Ala Glu Ile Ser Leu  Leu Glu Val Leu Glu  Asn Leu Arg 
    1055                 1060                 1065             


Lys Leu  Leu Ser Tyr Asp Arg  Lys Leu Lys Asn Ala  Ile Met Lys 
    1070                 1075                 1080             


Ser Ile  Val Asp Ile Leu Lys  Glu Tyr Gly Phe Val  Val Thr Phe 
    1085                 1090                 1095             


Lys Ile  Glu Lys Asp Lys Lys  Ile Arg Ile Glu Ser  Leu Lys Ser 
    1100                 1105                 1110             


Glu Glu  Val Val His Leu Lys  Lys Leu Lys Leu Lys  Asp Asn Asp 
    1115                 1120                 1125             


Lys Lys  Lys Glu Pro Ile Lys  Thr Tyr Arg Asn Ser  Lys Glu Leu 
    1130                 1135                 1140             


Cys Lys  Leu Val Lys Val Met  Phe Glu Tyr Lys Met  Lys Glu Lys 
    1145                 1150                 1155             


Lys Ser  Glu Asn 
    1160         


<210>  697
<211>  1104
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  697

Met Arg Ile Val Lys Pro His Gly Thr Ser Glu Thr His Phe Asp Lys 
1               5                   10                  15      


Glu Gly Arg Ile Arg Arg Tyr Val His Ser Asp Ser Phe Pro Cys Glu 
            20                  25                  30          


Pro Leu Glu Pro Lys Glu Phe Ala Thr Arg His Pro Lys Leu Val Ile 
        35                  40                  45              


Ala Gln Trp Val Ser Cys Ile Asp Lys Val Ile Thr Arg Pro His Gly 
    50                  55                  60                  


Asp Gly Leu Pro Ser Glu Thr Gln Trp Ser Leu Arg Asn Gly Leu Gly 
65                  70                  75                  80  


Lys Ala Ala Trp Asp Leu Ile Val Glu Arg Gly Leu Leu Asp Ala Pro 
                85                  90                  95      


Glu Lys Arg Leu Lys Arg Phe Glu Arg Gln Trp Trp Ala Arg Ile His 
            100                 105                 110         


Pro Tyr Gly Asn Glu Thr Asp Ala Asn Thr Pro Arg Asn Pro Tyr Gly 
        115                 120                 125             


His Trp Tyr Arg Ser Leu Ala Gly Gly Val Asp Ile Ala Glu Phe Asp 
    130                 135                 140                 


Pro Ala Thr Val Ala Asn Met Ile Tyr Ala His Leu Tyr Glu Asn Ala 
145                 150                 155                 160 


Ser Arg Thr His Pro Glu His Gly Pro Arg Arg Ser Gly Leu Ile Pro 
                165                 170                 175     


Glu Arg Ser Glu Ser Ile Ala Lys Ser Val Pro Ala Arg Thr Ala Pro 
            180                 185                 190         


Gly Gly Gly Arg Leu Ser Pro Pro Trp Asp Ala Ser Asp Gly Ala Ile 
        195                 200                 205             


Tyr Leu Glu Ala Gly Asp Val Ala Ala Thr Met Leu Glu Arg Leu Glu 
    210                 215                 220                 


Lys His Phe Gly Glu Arg His Ala Lys Leu Arg Arg Ile Cys Ala Ala 
225                 230                 235                 240 


Thr Leu Ala Glu His Leu Thr Arg Leu Arg Arg Glu Val Leu His Ile 
                245                 250                 255     


Ser Asp Gly Asp Arg Leu Pro Glu Ser Leu Tyr Gln Leu His Glu Gln 
            260                 265                 270         


Val Arg Arg Ser Tyr Ser Asp Ile Leu Lys Gly Asp Gln Arg Tyr Leu 
        275                 280                 285             


Ser Lys Lys Leu Pro Ser Ser Gly Asp Gln Leu Val Ser Leu Val Glu 
    290                 295                 300                 


Ser Lys Arg Leu Asn Arg Glu Val Ala Ala Leu Ile Arg Leu Gly Arg 
305                 310                 315                 320 


Val Ile His Tyr Glu Ser Thr Ala Glu Asn Gly Pro Ser His Thr Ser 
                325                 330                 335     


Asn Val Leu Asp His Trp Pro Ser Gln Thr Asp Ser Ser Arg Phe Trp 
            340                 345                 350         


Leu Ser Ala Gly Gln Thr Glu Ile Lys Arg Asn Glu Ala Phe Val Arg 
        355                 360                 365             


Ile Trp Arg Gly Ile Leu Ala Arg Ala Ala Arg Thr Ala Thr Asp Trp 
    370                 375                 380                 


Ala Asp Pro Glu Arg Ala Ile Pro Arg Asp Val Leu Gly Ala Lys Gln 
385                 390                 395                 400 


Leu Ser Glu Ala Val Thr Asn Ile Thr Asp Thr Ala Phe Asp Arg Lys 
                405                 410                 415     


Ala Lys Leu Leu Phe Gly Asn Arg Ser Asp Leu Leu Thr Ser Leu Pro 
            420                 425                 430         


Leu Glu Arg Lys Arg Gln Val Leu Asp Leu Ala Leu Arg Gly Leu Gly 
        435                 440                 445             


Gln Leu Arg Asn Asn Ala Phe His Phe Val Gly Leu Glu Ala Phe Leu 
    450                 455                 460                 


Ala Ser Leu Arg Gly Leu Asp Gly Ile Ala Asp Ala Asp Thr Arg Thr 
465                 470                 475                 480 


Val Leu Asp His Ile Trp Arg Asp Asp Thr Lys Asp Arg Asn Thr Arg 
                485                 490                 495     


Leu Val Gln Thr Ile Arg Ala Ser Asn Ala Pro Ala Tyr Phe Ser Arg 
            500                 505                 510         


Gln Glu Met Glu Gly Phe Val Ser Ser Ile Ala Arg Thr Pro Ala Val 
        515                 520                 525             


Phe Leu Glu Leu Pro Ala Phe Gly Arg Ile Leu Arg Arg Ala Ser Val 
    530                 535                 540                 


Ala Trp Thr Ile Asp Arg Tyr Arg Leu Thr Leu Pro Ala Pro Lys Ala 
545                 550                 555                 560 


Val Gly Glu Pro Val Ala Ala Glu Cys Gln Arg Val Cys Leu Gly Leu 
                565                 570                 575     


Ile Tyr Asp Arg Ala Phe Gly Asp Trp Leu Gln Val Leu Glu Thr Glu 
            580                 585                 590         


Arg Leu Arg Asp Cys Val Asp Arg Ala Val Thr Arg Ala Ser Val Glu 
        595                 600                 605             


Ala Arg Arg Val Thr Arg Asp Asp Thr Val Asn Ala Arg Thr Ile Gly 
    610                 615                 620                 


Lys Phe Lys Ile Thr Gln Gly Asp Thr Leu Glu Ser Phe Phe Ser Arg 
625                 630                 635                 640 


Leu Thr Ala Ala Val Thr Arg Glu Leu Arg Gln Thr Asp Ala Arg Lys 
                645                 650                 655     


Gln Thr Lys Arg Ala Ala Ser Lys His Leu Asp Asp Leu Arg Cys Asp 
            660                 665                 670         


Val Val Ala Gln Leu Phe Glu Ile Tyr Leu Lys Glu Ala Asp Leu Gly 
        675                 680                 685             


Trp Leu Leu Ser Gly Phe Gln Thr Arg Lys Pro Thr Gly Ala Ser Lys 
    690                 695                 700                 


Thr Asp Ala Ala Phe Cys Pro Pro Pro Ser Ser Ala Gln Thr Phe Gln 
705                 710                 715                 720 


Ala Trp Glu Pro Ile Leu Tyr Phe Ile Leu His Leu Val Pro Val Asp 
                725                 730                 735     


Thr Thr Thr Arg Leu Ala His Gln Val Gly Arg Phe Arg Asp Gly Gly 
            740                 745                 750         


Gln Ile Asp Thr Gly Leu Ile Glu Gly Leu Gln Arg Thr Leu Asp Leu 
        755                 760                 765             


Tyr Arg Val Met His Asp Ala Lys Phe Ala Gly Ala Ala Ser Gly Leu 
    770                 775                 780                 


Arg Pro Asp Glu Met Arg Ser Ile Leu Leu Lys Thr Gly Leu Tyr Ser 
785                 790                 795                 800 


Gly Ala Thr Glu Gly Thr Glu Leu Ala Phe Glu Thr Arg Gly Leu Arg 
                805                 810                 815     


Glu Phe Phe Arg Phe Gly Asp His His Leu Phe Thr Thr Asp Phe Ala 
            820                 825                 830         


Gln Asn Pro Val Thr Arg Asp Gln Phe His Glu Ile Lys Ser Leu Arg 
        835                 840                 845             


Ala Asp Leu Ala Leu Ala Gln Asp Arg Arg Ser Ala Leu His Ala Glu 
    850                 855                 860                 


Trp Val Ser Asn Gly Lys Ala Leu Ser Gly Ala Lys His Asp Glu Tyr 
865                 870                 875                 880 


Arg Ala Leu Leu Asn Arg Ile Glu Arg Gly Arg His Leu Ser Asp His 
                885                 890                 895     


Ala Glu Leu Arg Asp His Leu Arg Leu His Gly Ile Leu Ile Asp Val 
            900                 905                 910         


Leu Ala Arg Leu Leu Asp Phe Ala Gly Gln Trp Glu Arg Asp Leu Tyr 
        915                 920                 925             


Phe Thr Thr Leu Ala Leu Ile His Leu Ala Gly Thr Thr Pro Gln Asp 
    930                 935                 940                 


Ala Phe Asp Asp Arg Arg Gly Trp His Ala Val Arg Thr Gly Gln Ile 
945                 950                 955                 960 


Leu Ala Ala Leu Arg Ser Thr Arg Asp Thr Pro Glu Met Gln Asp Ile 
                965                 970                 975     


Leu Ala Lys Leu Ala Met Val Phe Asn Ile Asp Met Pro Gly Val Arg 
            980                 985                 990         


Gly Ala Asn Val Arg Thr Arg Asn  Asp Leu Ala His Phe  Asn Cys Leu 
        995                 1000                 1005             


His Thr  Pro Ala Ala Ser Ile  Asp Leu Thr Ala Leu  Ile Asn Arg 
    1010                 1015                 1020             


Thr Arg  Ala Leu Met His Tyr  Asp Arg Lys Gln Glu  Asn Ala Val 
    1025                 1030                 1035             


Ser Lys  Ser Val Ile Glu Leu  Leu Asp Arg His Lys  Leu Val Leu 
    1040                 1045                 1050             


Ser Trp  Thr Phe Ser Gly Gly  Gln Leu Gly Lys Ser  Thr Val Arg 
    1055                 1060                 1065             


Pro Lys  Val Ile Arg His Leu  Glu Gln Pro Glu Val  Lys Glu Cys 
    1070                 1075                 1080             


Leu Val  Ser Thr Ala Phe Ser  Ala Ala Val Gly Arg  Leu Phe Gly 
    1085                 1090                 1095             


Ala Thr  Glu Lys Asp Gly 
    1100                 


<210>  698
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  698

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asn Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Thr Phe Lys Asn Ile Val 
                485                 490                 495     


Pro Ser Gln Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Lys Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Ile Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Ser Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Lys Ile Pro Tyr Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Leu Lys Glu Leu Lys Glu Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn Tyr Arg Met Gln Gln Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Lys Lys Asp Glu Lys Phe Asn Asp Lys Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Thr Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Lys Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Glu  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  699
<211>  1157
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  699

Met Leu Arg Arg Met Cys Met Lys Ile Thr Lys Ile Asp Gly Ile Ser 
1               5                   10                  15      


His Lys Lys Tyr Lys Glu Lys Gly Lys Leu Ile Lys Ser Asn Glu Ile 
            20                  25                  30          


Glu Lys Asp Ile Thr Glu Glu Arg Phe Asn Asp Ile Glu Ala Lys Thr 
        35                  40                  45              


Thr Glu Leu Phe Gln Lys Thr Leu Asp Phe Tyr Val Lys Asn Tyr Glu 
    50                  55                  60                  


Asn Ser Glu Asp Gln Asn Lys Glu Arg Arg Glu Lys Ala Lys Asn Tyr 
65                  70                  75                  80  


Phe Ser Lys Val Lys Ile Leu Val Asp Asn Lys Lys Ile Thr Ile Cys 
                85                  90                  95      


Asn Glu Asn Thr Glu Lys Met Glu Ile Glu Asp Phe Asn Glu Tyr Asp 
            100                 105                 110         


Val Arg Ser Gly Lys Tyr Phe Asn Val Leu Asn Lys Ile Leu Asn Gly 
        115                 120                 125             


Glu Asn Tyr Thr Glu Glu Asp Leu Glu Val Phe Glu Asn Asp Leu Gln 
    130                 135                 140                 


Lys Arg Ile Gly Arg Ile Lys Ser Ile Lys Asn Ser Leu Glu Glu Asn 
145                 150                 155                 160 


Lys Ala His Phe Lys Lys Glu Ser Ile Asn Asn Asn Ile Ile Tyr Asp 
                165                 170                 175     


Arg Val Lys Gly Asn Asn Lys Lys Ser Leu Phe Tyr Glu Tyr Tyr Arg 
            180                 185                 190         


Ile Ser Ser Lys His Gln Glu Tyr Val Asn Asn Ile Phe Glu Ala Phe 
        195                 200                 205             


Asp Lys Leu Tyr Ser Asn Ser His Glu Ala Met Asn Asn Leu Phe Ser 
    210                 215                 220                 


Glu Ile Thr Lys Asp Ser Lys Glu Arg Asn Ile Arg Lys Thr Arg Glu 
225                 230                 235                 240 


Ala Tyr His Glu Ile Leu Asn Lys Asn Lys Thr Glu Phe Gly Glu Glu 
                245                 250                 255     


Leu Tyr Lys Lys Ile Gln Asp Asn Ile Ser Asn Phe Asp Lys Leu Leu 
            260                 265                 270         


Glu Ile Glu Pro Glu Ile Lys Glu Leu Thr Lys Ser Gln Ile Phe Tyr 
        275                 280                 285             


Lys Tyr Tyr Ile Asp Lys Val Asn Leu Asp Glu Thr Thr Ile Lys His 
    290                 295                 300                 


Cys Phe Cys His Leu Val Glu Ile Glu Val Asn Gln Leu Leu Lys Asn 
305                 310                 315                 320 


Tyr Val Tyr Ser Lys Arg Asn Ile Asn Lys Glu Lys Leu Glu Asn Ile 
                325                 330                 335     


Phe Glu Tyr Cys Lys Leu Lys Asn Leu Val Lys Asn Lys Leu Val Asn 
            340                 345                 350         


Lys Leu Asn Asn Tyr Ile Arg Asn Cys Gly Lys Tyr Asn Ala Tyr Ile 
        355                 360                 365             


Ser Asn Asn Asp Val Val Val Asn Ser Glu Lys Ile Ser Glu Ile Arg 
    370                 375                 380                 


Thr Lys Glu Ala Phe Leu Arg Ser Ile Ile Gly Val Ser Ser Ser Ala 
385                 390                 395                 400 


Tyr Phe Ser Leu Arg Asn Ile Leu Asn Thr Asp Asn Thr Gln Asp Ile 
                405                 410                 415     


Thr Asn Lys Val Asp Lys Glu Val Asp Lys Leu Tyr Gln Glu Asn Lys 
            420                 425                 430         


Lys Ile Glu Leu Glu Glu Arg Leu Lys Leu Phe Phe Gly Asn Tyr Phe 
        435                 440                 445             


Asp Ile Asn Asn Gln Gln Glu Ile Lys Val Phe Leu Met Asn Ile Asp 
    450                 455                 460                 


Lys Ile Ile Ser Ser Ile Arg His Glu Ile Ile His Phe Lys Met Glu 
465                 470                 475                 480 


Thr Asn Ala Gln Asn Ile Phe Asp Phe Asn Asn Val Asn Leu Gly Asn 
                485                 490                 495     


Thr Ala Lys Asn Ile Phe Ser Asn Glu Ile Asn Glu Glu Lys Ile Lys 
            500                 505                 510         


Phe Lys Ile Phe Lys Gln Leu Asn Ser Ala Asn Ile Phe Asp Tyr Leu 
        515                 520                 525             


Ser Asn Lys Asp Ile Thr Glu Tyr Met Asp Lys Val Val Phe Ser Phe 
    530                 535                 540                 


Thr Asn Arg Asn Val Ser Phe Val Pro Ser Phe Thr Lys Ile Tyr Asn 
545                 550                 555                 560 


Arg Val Gln Asp Leu Ala Asn Ser Leu Glu Ile Lys Glu Trp Lys Ile 
                565                 570                 575     


Pro Asp Glu Ser Glu Gly Lys Asp Ala Gln Ile Tyr Leu Leu Lys Asn 
            580                 585                 590         


Ile Tyr Tyr Gly Lys Phe Leu Asp Lys Phe Leu Asn Glu Glu Asn Gly 
        595                 600                 605             


Ile Phe Ile Ser Ile Lys Asp Lys Ile Ile Glu Leu Asn Arg Asn Gln 
    610                 615                 620                 


Asn Lys Arg Thr Gly Phe Tyr Lys Leu Glu Lys Phe Glu Lys Ile Glu 
625                 630                 635                 640 


Glu Thr Asn Pro Lys Lys Tyr Leu Glu Ile Ile Gln Ser Leu Tyr Met 
                645                 650                 655     


Ile Asn Ile Glu Glu Ile Asp Ser Glu Gly Lys Asn Ile Phe Leu Asp 
            660                 665                 670         


Phe Ile Gln Lys Ile Phe Leu Lys Gly Phe Phe Glu Phe Ile Lys Asn 
        675                 680                 685             


Asp Tyr Asn Tyr Leu Leu Glu Leu Lys Lys Val Gln Asp Lys Lys Asn 
    690                 695                 700                 


Ile Phe Asp Ser Lys Met Ser Glu Tyr Ile Ala Gly Glu Lys Thr Leu 
705                 710                 715                 720 


Glu Asp Ile Gly Glu Ile Asn Glu Ile Ile Gln Lys Ile Glu Ile Thr 
                725                 730                 735     


Lys Ile Asp Lys Ile Leu Asn Gln Thr Asp Arg Ile Asn Ser Phe Tyr 
            740                 745                 750         


Leu Leu Leu Lys Leu Leu Asn Tyr Lys Glu Ile Thr Glu Leu Lys Gly 
        755                 760                 765             


Asn Leu Glu Lys Tyr Gln Ile Leu Ser Lys Thr Asn Val Tyr Glu Lys 
    770                 775                 780                 


Glu Leu Met Leu Leu Asn Ile Val Asn Leu Asp Asn Asn Lys Val Lys 
785                 790                 795                 800 


Ile Glu Asn Phe Lys Ile Ser Ala Glu Glu Ile Gly Lys Phe Ile Glu 
                805                 810                 815     


Lys Ile Asn Ile Glu Glu Ile Asn Lys Lys Ile Lys Thr Phe Glu Glu 
            820                 825                 830         


Leu Arg Asn Phe Glu Lys Gly Glu Asn Thr Gly Glu Tyr Tyr Asn Ile 
        835                 840                 845             


Tyr Ser Asp Asp Lys Asn Ile Lys Asn Ile Arg Asn Leu Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asp Leu Leu Glu Lys Ile Ser Glu Lys Thr 
865                 870                 875                 880 


Asn Tyr Cys Ile Lys Lys Lys Asp Leu Glu Glu Tyr Ser Lys Leu Arg 
                885                 890                 895     


Lys Gln Leu Glu Asp Lys Lys Lys Glu Asn Glu Lys Ile Glu Asp Glu 
            900                 905                 910         


Lys Thr Asn Phe Tyr Lys Ile Gln Glu Tyr Leu His Ser Lys Tyr Gln 
        915                 920                 925             


Gln Glu Pro Lys Lys Ile Leu Trp Lys Asn Asn Lys Asn Asp Tyr Glu 
    930                 935                 940                 


Lys Tyr Lys Lys Ser Ile Glu Asn Ile Glu Lys Tyr Val His Leu Lys 
945                 950                 955                 960 


Asn Lys Ile Glu Phe Asn Glu Leu Asn Leu Leu Gln Ser Leu Leu Leu 
                965                 970                 975     


Lys Ile Leu His Arg Leu Val Gly Phe Thr Ser Ile Trp Glu Arg Asp 
            980                 985                 990         


Leu Arg Phe Arg Leu Thr Gly Glu  Phe Pro Asp Glu Leu  Asp Ile Glu 
        995                 1000                 1005             


Asp Ile  Phe Asp His Arg Lys  Arg Tyr Lys Gly Thr  Gly Gly Gly 
    1010                 1015                 1020             


Ile Cys  Lys Lys Tyr Asp Arg  Phe Ile Asn Thr Tyr  Thr Glu Tyr 
    1025                 1030                 1035             


Lys Asn  Asn Asn Lys Met Lys  Asn Val Lys Phe Ala  Asp Asn Asn 
    1040                 1045                 1050             


Pro Val  Arg Asn Tyr Ile Ala  His Phe Asn Tyr Leu  Pro Asn Pro 
    1055                 1060                 1065             


Lys Tyr  Ser Ile Leu Lys Met  Met Glu Lys Leu Arg  Lys Leu Leu 
    1070                 1075                 1080             


Asp Tyr  Asp Arg Lys Leu Lys  Asn Ala Val Met Lys  Ser Ile Lys 
    1085                 1090                 1095             


Asp Ile  Leu Glu Glu Tyr Gly  Phe Lys Ala Glu Phe  Ile Ile Asn 
    1100                 1105                 1110             


Ser Asp  Lys Glu Ile Ile Leu  Asn Pro Val Lys Ser  Val Glu Ile 
    1115                 1120                 1125             


Ile His  Leu Gly Lys Glu Asp  Leu Lys Ser Arg Arg  Asn Ser Glu 
    1130                 1135                 1140             


Asp Leu  Cys Lys Leu Val Lys  Ala Met Leu Glu Tyr  Ser Glu 
    1145                 1150                 1155         


<210>  700
<211>  1192
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  700

Met Lys Val Thr Lys Ile Asp Gly Leu Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Phe Arg Asp Asn Lys Asn Ile Asn Glu Met 
            20                  25                  30          


Lys Glu Arg Leu Glu Lys Leu Lys Glu Leu Lys Leu Asp Asn Tyr Ile 
        35                  40                  45              


Lys Asn Pro Glu Asn Val Lys Asn Glu Asp Lys Glu Ala Glu Lys Glu 
    50                  55                  60                  


Thr Lys Ile Arg Arg Thr Asn Leu Lys Lys Tyr Phe Ser Glu Ile Ile 
65                  70                  75                  80  


Leu Arg Glu Lys Asp Lys Lys Tyr Leu Leu Val Lys Thr Lys Lys Phe 
                85                  90                  95      


Lys Asn Ile Asn Gln Glu Met Asp Tyr Tyr Asp Ile Lys Lys Lys Glu 
            100                 105                 110         


Asn Gln Gln Glu Ile Phe Asp Val Leu Lys Glu Ile Leu Glu Leu Glu 
        115                 120                 125             


Ile Lys Glu Asn Gln Glu Glu Asn Ile Asp Phe Asp Ser Glu Lys Leu 
    130                 135                 140                 


Lys Glu Ala Phe Glu Lys Asp Phe Ile Lys Lys Val Ser Lys Ile Glu 
145                 150                 155                 160 


Ala Val Lys Lys Ser Leu Glu Ile Asn Arg Ala Asn Tyr Lys Lys Asp 
                165                 170                 175     


Phe Val Glu Ile Gly Asn Asp Lys Tyr Glu Asn Val Lys Gly Glu Asn 
            180                 185                 190         


Lys Arg Ser Arg Val Tyr Glu Tyr Tyr Lys Lys Ser Glu Thr His Glu 
        195                 200                 205             


Lys Phe Arg Lys Asn Ile Thr Glu Ala Phe Glu Lys Leu Tyr Thr Glu 
    210                 215                 220                 


Glu Asn Ile Lys Glu Leu Tyr Ser Lys Ile Glu Glu Val Lys Lys Lys 
225                 230                 235                 240 


Thr His Leu Lys Ser Ile Val Arg Glu Phe Tyr Gln Asn Glu Ile Ile 
                245                 250                 255     


Gly Glu Ser Glu Phe Ser Glu Lys Gly Glu Asp Gly Ile Ser Ile Leu 
            260                 265                 270         


Tyr Asn Gln Ile Ile Arg Ser Asn Glu Lys Lys Glu Lys Phe Val Lys 
        275                 280                 285             


Phe Leu Glu Asn Ile Glu Asn Leu Gln Leu Lys Glu Leu Thr Lys Ser 
    290                 295                 300                 


Gln Ile Phe Tyr Lys Tyr Phe Leu Glu Asn Glu Glu Leu Asp Asp Glu 
305                 310                 315                 320 


Asn Ile Lys Asn Val Phe Cys Tyr Phe Val Glu Ile Glu Val Asn Asp 
                325                 330                 335     


Leu Leu Lys Gly Asn Val Tyr Arg Val Ser Lys Ile Tyr Glu Asn Lys 
            340                 345                 350         


Ile Lys Asn Thr Phe Glu Tyr Asn Lys Leu Lys Lys Leu Val Ile Asn 
        355                 360                 365             


Lys Leu Glu Asn Lys Leu Asn Asn Tyr Val Arg Asn Cys Gly Lys Tyr 
    370                 375                 380                 


Asn Tyr His Met Glu Asn Gly Asp Ile Ala Thr Ser Asp Ile Asn Met 
385                 390                 395                 400 


Arg Asn Arg Gln Thr Glu Ala Phe Leu Arg Ser Met Ile Gly Val Ser 
                405                 410                 415     


Ser Phe Gly Tyr Phe Ser Leu Arg Asn Ile Leu Gly Val Asn Asp Asp 
            420                 425                 430         


Asp Phe Tyr Glu Ile Glu Glu Asp Leu Thr Glu Asp Glu Arg Lys Lys 
        435                 440                 445             


Glu Ile Ser Thr Leu Lys Lys Val Lys Glu Asp Ile Ala Ser Lys Ser 
    450                 455                 460                 


Ile Phe Glu Lys Val Val Asp Lys Ser Phe Gln Lys Lys Gly Ile Tyr 
465                 470                 475                 480 


Asn Ile Lys Glu Asn Leu Lys Met Phe Tyr Gly Asp Ser Phe Asp Asp 
                485                 490                 495     


Ala Asp Glu Asp Glu Leu Lys Gln Phe Phe Val Asn Met Leu Asn Ala 
            500                 505                 510         


Ile Thr Ser Ile Arg His Lys Val Val His Tyr Asn Met Asn Thr Asn 
        515                 520                 525             


Ser Glu Asn Ile Phe Asn Phe Ser Asp Ile Glu Val Ser Arg Leu Leu 
    530                 535                 540                 


Lys Asn Ile Phe Glu Lys Glu Thr Asp Lys Arg Glu Leu Lys Leu Lys 
545                 550                 555                 560 


Ile Phe Arg Gln Leu Asn Ser Ala Gly Val Phe Asp Tyr Trp Glu Ser 
                565                 570                 575     


Trp Lys Ile Lys Lys Tyr Leu Glu Asn Ile Glu Phe Lys Phe Val Asn 
            580                 585                 590         


Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys Leu Tyr Asn Arg Ile 
        595                 600                 605             


Asp Asn Leu Lys Gly Ser Asn Ala Leu Asn Leu Gly Tyr Ile Asn Ile 
    610                 615                 620                 


Pro Lys Arg Lys Glu Ala Arg Asp Ser Gln Ile Tyr Leu Leu Lys Asn 
625                 630                 635                 640 


Ile Tyr Tyr Gly Glu Phe Val Glu Lys Phe Val Asn Asn Asn Asp Asn 
                645                 650                 655     


Phe Glu Lys Ile Phe Arg Glu Ile Ile Glu Ile Asn Lys Asn Ala Gly 
            660                 665                 670         


Thr Asn Thr Lys Thr Lys Phe Tyr Lys Leu Glu Lys Phe Glu Thr Leu 
        675                 680                 685             


Lys Ala Asn Thr Pro Thr Glu Tyr Leu Glu Lys Leu Gln Ser Leu His 
    690                 695                 700                 


Gln Ile Asn Tyr Asp Arg Glu Lys Ile Glu Glu Asp Lys Asp Ile Tyr 
705                 710                 715                 720 


Val Asp Phe Val Gln Lys Ile Phe Leu Lys Gly Phe Ile Asn Tyr Leu 
                725                 730                 735     


Gln Glu Ser Gly Ser Leu Lys Tyr Leu Leu Asn Ser Glu Lys Arg Glu 
            740                 745                 750         


Val Ile Ala Asn Lys Lys Ser Ser Tyr Asp Glu Lys Leu Lys Leu Trp 
        755                 760                 765             


Gln Asn Asn Gly Ser Asn Leu Ser Lys Met Pro Glu Glu Ile Tyr Asp 
    770                 775                 780                 


Tyr Ile Lys Lys Ile Lys Ile Thr Lys Ile Asn Tyr Ser Asp Arg Met 
785                 790                 795                 800 


Ser Ile Phe Tyr Leu Leu Leu Lys Leu Ile Asp His Arg Glu Leu Thr 
                805                 810                 815     


Asn Leu Arg Gly Asn Leu Glu Lys Tyr Glu Ser Ile Asn Lys Asn Glu 
            820                 825                 830         


Ile Tyr Ser Glu Glu Leu Asn Ile Val Asn Leu Val Ser Leu Asp Asn 
        835                 840                 845             


Asn Lys Val Arg Ala Asn Phe Asn Leu Glu Pro Glu Asp Ile Gly Lys 
    850                 855                 860                 


Phe Leu Lys Thr Glu Thr Ser Ile Lys Asn Ile Asn Gln Leu Asn Asn 
865                 870                 875                 880 


Phe Ser Lys Ile Phe Ala Asp Gly Glu Asn Val Ile Lys His Arg Ser 
                885                 890                 895     


Phe Tyr Asn Ile Lys Lys Tyr Gly Ile Leu Asp Leu Leu Glu Lys Ile 
            900                 905                 910         


Val Ala Lys Ala Asp Leu Lys Ile Thr Lys Glu Glu Ile Lys Lys Tyr 
        915                 920                 925             


Glu Asn Leu Gln Asn Glu Leu Lys Arg Asn Asp Phe Tyr Lys Ile Gln 
    930                 935                 940                 


Glu Arg Ile His Arg Asn Tyr Asn Gln Lys Pro Phe Leu Ile Lys Asn 
945                 950                 955                 960 


Asn Glu Lys Asp Phe Asn Asp Tyr Lys Lys Ala Ile Glu Asn Ile Gln 
                965                 970                 975     


Asn Tyr Thr Gln Leu Lys Asn Lys Ile Glu Phe Asn Asp Leu Asn Leu 
            980                 985                 990         


Leu Gln Ser Leu Leu Phe Arg Ile  Leu His Arg Leu Ala  Gly Tyr Thr 
        995                 1000                 1005             


Ser Leu  Trp Glu Arg Asp Leu  Gln Phe Lys Leu Lys  Gly Glu Phe 
    1010                 1015                 1020             


Pro Glu  Asp Lys Tyr Ile Asp  Glu Ile Phe Asn Ser  Asp Gly Asn 
    1025                 1030                 1035             


Asn Asn  Gln Lys Tyr Lys Asn  Gly Gly Ile Ala Asp  Lys Tyr Ala 
    1040                 1045                 1050             


Asp Phe  Leu Ile Glu Lys Glu  Glu Glu Lys Ser Gly  Glu Ile Leu 
    1055                 1060                 1065             


Lys Lys  Asn Gln Arg Ile Lys  Arg Lys Lys Lys Ile  Lys Glu Asp 
    1070                 1075                 1080             


Leu Glu  Ile Arg Asn Tyr Ile  Ala His Phe Asn Tyr  Phe Pro Asp 
    1085                 1090                 1095             


Ala Thr  Lys Ser Ile Leu Glu  Leu Leu Glu Glu Leu  Arg Glu Leu 
    1100                 1105                 1110             


Leu Lys  Tyr Asp Arg Lys Leu  Lys Asn Ala Val Met  Glu Ser Val 
    1115                 1120                 1125             


Lys Asp  Ile Phe Lys Glu Tyr  Gly Phe Ile Val Glu  Phe Glu Ile 
    1130                 1135                 1140             


Ser His  Glu Ser Asn Ser Lys  Lys Ile Lys Val Cys  Asp Ile Lys 
    1145                 1150                 1155             


Ser Glu  Glu Ile Lys His Leu  Lys Asn Asn Gly Leu  Val Thr Thr 
    1160                 1165                 1170             


Arg Asn  Ser Glu Asp Leu Cys  Glu Leu Ile Lys Val  Met Leu Glu 
    1175                 1180                 1185             


Tyr Lys  Lys Ser 
    1190         


<210>  701
<211>  1400
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  701

Leu Phe Leu Trp Ile Ile Glu Glu Val Ile Tyr Glu Ile Ile Lys Leu 
1               5                   10                  15      


Tyr Lys Asn Leu Lys Glu Glu Ile Ile Met Gly Asn Leu Phe Gly Tyr 
            20                  25                  30          


Lys Arg Trp Tyr Glu Val Arg Asp Lys Glu Asp Tyr Lys Ile Lys Arg 
        35                  40                  45              


Lys Val Lys Val Lys Arg Asn Tyr Asp Gly Asn Lys Tyr Ile Leu Asn 
    50                  55                  60                  


Ile Asn Glu Asn Asn Asn Lys Glu Lys Ile Asn Asp Asn Lys Phe Ile 
65                  70                  75                  80  


Arg Glu Phe Val Asn Tyr Lys Lys Asn Asp Asn Val Leu Ile Glu Phe 
                85                  90                  95      


Lys Arg Lys Phe His Ala Gly Asn Ile Leu Phe Lys Leu Lys Gly Lys 
            100                 105                 110         


Glu Arg Ile Lys Arg Ile Glu Asn Asp Asp Asp Phe Leu Lys Thr Glu 
        115                 120                 125             


Glu Val Val Leu Tyr Ile Glu Val Tyr Gly Lys Ser Glu Lys Leu Lys 
    130                 135                 140                 


Ala Leu Gly Ile Thr Lys Lys Lys Ile Ile Asp Glu Ala Ile Lys Gln 
145                 150                 155                 160 


Gly Ile Thr Lys Asp Asp Lys Lys Ile Glu Ile Lys Arg Gln Lys Ile 
                165                 170                 175     


Glu Ile Asn Ile Arg Asp Lys Cys Thr Asn Lys Thr Val Asp Asp Cys 
            180                 185                 190         


Ser Val Ile Leu Arg Ile Ile Glu Asn Asp Glu Leu Glu Thr Lys Lys 
        195                 200                 205             


Ser Ile Tyr Glu Ile Phe Lys Asn Ile Asn Met Asn Leu Tyr Lys Ile 
    210                 215                 220                 


Ile Glu Lys Ile Ile Val Asn Lys Thr Glu Lys Val Phe Glu Asn Arg 
225                 230                 235                 240 


Tyr Tyr Lys Glu Tyr Leu Lys Glu Lys Leu Leu Glu Asp Asn Gln Ile 
                245                 250                 255     


Asn Ile Ile Leu Thr Asn Phe Met Lys Ile Arg Glu Lys Ile Glu Ser 
            260                 265                 270         


Asn Pro Glu Ile Met Gly Phe Val Lys Phe Tyr Phe Asn Val Gly Gly 
        275                 280                 285             


Asp Lys Lys Lys Ser Glu Asn Lys Lys Met Phe Val Glu Lys Ile Leu 
    290                 295                 300                 


Asn Ile Asn Val Asp Leu Thr Val Glu Asp Ile Val Asp Phe Ile Val 
305                 310                 315                 320 


Lys Glu Leu Lys Phe Trp Asp Ile Thr Lys Arg Ile Glu Lys Leu Gln 
                325                 330                 335     


Glu Lys Thr Val Asn Arg Thr Asp Glu Asp Ile Lys Lys Thr Tyr Ile 
            340                 345                 350         


Asn Thr Tyr Val Ser Leu Asp Lys His Glu Lys Phe Lys Lys Tyr Asn 
        355                 360                 365             


Arg Asn Lys Lys Asp Thr Ile Val Lys Ser Phe Ile Lys Asp Ile Lys 
    370                 375                 380                 


Asp Asn Thr Met Lys Gln Lys Ile Asn Gln Ile Leu Arg Lys Phe Lys 
385                 390                 395                 400 


Ile Glu Glu Leu Ile Glu Lys Leu Arg Ile Glu Asn Lys Asn Phe Asp 
                405                 410                 415     


Thr Glu Ile Phe Arg Ile Phe Lys Asp His Tyr Gln Glu Met Phe Ser 
            420                 425                 430         


Ser Glu Lys Phe Glu Glu Lys Ser Asp Glu Glu Lys Glu Leu Tyr Lys 
        435                 440                 445             


Ile Ile Tyr Arg Tyr Leu Lys Gly Arg Ile Glu Lys Ile Leu Ile Asn 
    450                 455                 460                 


Gly Glu Lys Val Arg Leu Lys Lys Met Glu Lys Ile Glu Ile Glu Lys 
465                 470                 475                 480 


Ile Leu Asn Glu Ser Ile Leu Ser Glu Lys Ile Leu Lys Arg Ile Lys 
                485                 490                 495     


Gln Tyr Thr Leu Glu His Ile Met Tyr Leu Gly Lys Leu Arg His Asn 
            500                 505                 510         


Asp Ile Val Lys Met Thr Val Asn Thr Asn Asp Phe Ser Arg Leu His 
        515                 520                 525             


Ala Lys Glu Glu Leu Asp Leu Glu Leu Ile Thr Phe Phe Ala Ser Thr 
    530                 535                 540                 


Asn Met Glu Leu Asn Lys Ile Phe Asn Gly Lys Glu Lys Ile Thr Asp 
545                 550                 555                 560 


Phe Phe Gly Phe Asn Leu Asn Gly Gln Lys Ile Thr Leu Lys Glu Lys 
                565                 570                 575     


Val Pro Ser Phe Lys Leu Asn Ile Leu Lys Lys Leu Asn Phe Ile Asn 
            580                 585                 590         


Asn Glu Asn Asn Ile Asp Glu Lys Leu Ser His Phe Tyr Ser Phe Gln 
        595                 600                 605             


Lys Glu Gly Tyr Leu Leu Arg Asn Lys Ile Leu His Asn Ser Tyr Gly 
    610                 615                 620                 


Asn Ile Gln Glu Thr Ile Asn Leu Lys Gly Glu Tyr Glu Asn Ile Glu 
625                 630                 635                 640 


Asn Leu Ile Lys Glu Leu Lys Val Asn Asn Glu Glu Ile Ser Lys Ser 
                645                 650                 655     


Leu Asn Leu Asp Ile Ile Phe Glu Gly Lys Val Asp Ile Ile Asn Lys 
            660                 665                 670         


Ile Asn Ser Leu Glu Ile Gly Glu Tyr Lys Asp Lys Lys Tyr Leu Pro 
        675                 680                 685             


Ser Phe Ser Lys Ile Val Pro Glu Ile Thr Arg Lys Phe Arg Glu Ile 
    690                 695                 700                 


Asn Lys Asp Lys Ser Phe Asp Ile Glu Ser Glu Lys Ile Ile Leu Asn 
705                 710                 715                 720 


Ala Val Gln Tyr Val Asn Lys Ile Leu Tyr Glu Lys Ile Thr Ser Asn 
                725                 730                 735     


Glu Glu Asn Glu Phe Ile Lys Thr Leu Pro Asp Lys Leu Val Lys Lys 
            740                 745                 750         


Asn Asn Asn Lys Glu Asn Lys Asn Ser Leu Ser Ile Glu Glu Tyr Tyr 
        755                 760                 765             


Lys Asn Ala Gln Val Ser Ser Ser Lys Gly Asp Lys Lys Ala Ile Lys 
    770                 775                 780                 


Lys Tyr Gln Asn Lys Val Thr Asn Ala Tyr Ile Glu Tyr Leu Glu Asn 
785                 790                 795                 800 


Thr Phe Ala Glu Val Ile Asn Phe Ser Asn Phe Asn Leu Asn Phe Asp 
                805                 810                 815     


Glu Ile Lys Thr Lys Ile Glu Glu Arg Lys Asp Ser Lys Ser Lys Ile 
            820                 825                 830         


Thr Ile Asp Ser Ile Ser Thr Asn Ile Asn Ile Thr Asn Asp Ile Glu 
        835                 840                 845             


Tyr Ile Ile Ser Ile Phe Ala Leu Leu Asn Ser Asn Thr Tyr Ile Asn 
    850                 855                 860                 


Lys Ile Arg Asn Arg Phe Phe Ala Thr Ser Val Trp Leu Asn Thr Gln 
865                 870                 875                 880 


Lys Tyr Glu Asn Ile Ile Asp Ile Leu Asp Glu Ile Leu Ser Ile Asn 
                885                 890                 895     


Leu Leu Arg Glu Asn Asn Ile Ala Asp Ile Leu Asp Leu Lys Asn Thr 
            900                 905                 910         


Ile Ile Glu Thr Lys Ile Val Glu Asn Asn Glu Glu Ser Ile Arg Asn 
        915                 920                 925             


Tyr Ile Phe Gly Asn Asn Glu Glu Glu Leu Lys Lys Arg Leu Phe Phe 
    930                 935                 940                 


Glu Glu Leu Val Asn Lys Glu Asp Val Leu Lys Ile Phe Glu Asp Lys 
945                 950                 955                 960 


Asn Phe Lys Phe Lys Asn Phe Ile Lys Lys Asn Glu Ile Gly Asn Phe 
                965                 970                 975     


Lys Ile Asn Phe Gly Val Leu Ser Asn Leu Glu Cys Asn Ser Glu Val 
            980                 985                 990         


Glu Ala Lys Lys Ile Ile Gly Gln  Asn Ser Lys Lys Leu  Glu Ser Phe 
        995                 1000                 1005             


Ile Gln  Asn Ile Ile Asp Glu  Tyr Lys Ser Lys Ile  Lys Thr Ser 
    1010                 1015                 1020             


Phe Ser  Ser Glu Phe Leu Glu  Lys Tyr Lys Lys Glu  Ile Asp Asn 
    1025                 1030                 1035             


Leu Val  Glu Asp Thr Glu Ala  Glu Asn Lys Asn Lys  Phe Glu Lys 
    1040                 1045                 1050             


Ile Tyr  Tyr Pro Glu Glu His  Lys Asn Glu Leu Tyr  Ile Tyr Lys 
    1055                 1060                 1065             


Lys Asn  Leu Phe Leu Asn Ile  Gly Asn Pro Asn Phe  Asp Lys Ile 
    1070                 1075                 1080             


Tyr Glu  Leu Ile Ser Lys Asp  Ile Lys Asn Ala Asn  Thr Glu Ile 
    1085                 1090                 1095             


Leu Phe  Asn Asp Asp Ile Arg  Lys Asn Lys Ile Ala  Glu Ile Asp 
    1100                 1105                 1110             


Val Ile  Leu Lys Asn Leu Asn  Asp Lys Leu Asn Gly  Tyr Ser Lys 
    1115                 1120                 1125             


Glu Tyr  Lys Glu Lys Tyr Ile  Lys Lys Leu Lys Glu  Asn Gln Glu 
    1130                 1135                 1140             


Asn Asn  Asp Phe Phe Ala Lys  Asn Ile Gln Asn Glu  Asn Tyr Ser 
    1145                 1150                 1155             


Ser Phe  Arg Glu Phe Lys Glu  Asp Tyr Asn Lys Val  Ser Glu Tyr 
    1160                 1165                 1170             


Lys Lys  Ile Arg Asp Leu Val  Glu Phe Asn Tyr Leu  Asn Lys Ile 
    1175                 1180                 1185             


Glu Ser  Tyr Leu Ile Asp Ile  Asn Trp Lys Leu Ala  Ile Gln Met 
    1190                 1195                 1200             


Ala Arg  Phe Glu Arg Asp Met  His Tyr Ile Val Asn  Gly Leu Arg 
    1205                 1210                 1215             


Glu Leu  Gly Ile Ile Lys Leu  Asn Gly Tyr Asn Thr  Gly Ile Ser 
    1220                 1225                 1230             


Arg Ala  Tyr Pro Lys Arg Asn  Gly Ser Asp Asp Phe  Tyr Ala Thr 
    1235                 1240                 1245             


Thr Ala  Tyr Tyr Lys Phe Phe  Asp Glu Glu Ser Tyr  Lys Lys Phe 
    1250                 1255                 1260             


Glu Lys  Ile Cys Tyr Lys Phe  Gly Ile Asp Leu Ser  Glu Asn Ser 
    1265                 1270                 1275             


Glu Ile  Asn Lys Pro Glu Asn  Glu Ser Ile Arg Asn  Tyr Ile Ser 
    1280                 1285                 1290             


His Phe  Tyr Ile Val Arg Asn  Pro Phe Ile Asp Tyr  Ser Ile Ala 
    1295                 1300                 1305             


Glu Gln  Ile Asp Arg Val Ser  Asn Leu Leu Ser Tyr  Ser Thr Arg 
    1310                 1315                 1320             


Tyr Asn  Asn Ser Thr Tyr Ala  Ser Val Phe Glu Val  Phe Lys Lys 
    1325                 1330                 1335             


Asp Val  Asp Leu Asp Tyr Asp  Glu Leu Lys Lys Lys  Phe Lys Leu 
    1340                 1345                 1350             


Ile Gly  Asp Asn Asp Ile Leu  Glu Lys Leu Met Lys  Ser Lys Lys 
    1355                 1360                 1365             


Val Ser  Val Leu Glu Leu Glu  Ser Tyr Asn Ser Asp  Tyr Val Lys 
    1370                 1375                 1380             


Asn Leu  Ile Ile Lys Leu Leu  Thr Lys Ile Glu Asn  Thr Asn Asp 
    1385                 1390                 1395             


Thr Leu  
    1400 


<210>  702
<211>  1154
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  702

Met Gly Ser Gly Lys Tyr Arg Ile Thr Lys Ile Ala Arg Asn Trp Asp 
1               5                   10                  15      


Lys Asn Lys Glu Arg Ile Thr Leu Lys Arg Ile Val Ser Asp Gly Gln 
            20                  25                  30          


Val Lys Tyr Val Asn Glu Asn Asp Asn Val Asp Met Asp Ile Thr Glu 
        35                  40                  45              


Thr Tyr Tyr Lys Ile Leu Ser Asn Asn Glu Ala Lys Phe Leu Gly Ser 
    50                  55                  60                  


Met Glu Gln Phe Ile Phe Lys Val Asn Lys Met Lys Arg Asn Ile Lys 
65                  70                  75                  80  


Asn Asn Cys Val Ile Ile Lys Asp Tyr Thr Glu Glu Glu Tyr Asp Lys 
                85                  90                  95      


Phe Glu Glu Lys Asn Tyr Lys Ile Phe Lys Lys Leu Ile Ile Ala Glu 
            100                 105                 110         


Glu Gln Gly Lys Asn Val Lys Lys Lys Lys Ile Cys Arg Asn Phe Tyr 
        115                 120                 125             


Glu Asp Glu Arg Glu Ile Met Glu Lys Arg Leu Glu Glu Ala Lys Asn 
    130                 135                 140                 


Phe Asn Asn Ile Ile Phe Asn Ile Cys Asn Lys Ile Phe Lys Leu Glu 
145                 150                 155                 160 


Tyr Leu Asp Tyr Thr Asp Glu Lys Val Tyr Lys Ile Phe His Glu Glu 
                165                 170                 175     


Ile Lys Phe Glu Asp Ile Lys Asn Leu Lys Glu Ala Phe Lys Gln Gln 
            180                 185                 190         


Glu Lys Gly Leu Glu Thr Asp Lys Leu Leu Ala Ile Ser Phe Asn Lys 
        195                 200                 205             


Lys Arg Asn Asn Ile Leu Leu Glu Phe Ile Gln Gln Ile Val Lys Gln 
    210                 215                 220                 


Lys Phe Lys Asn Glu Lys Glu Leu Glu Asn Trp Phe Ser His Glu Gly 
225                 230                 235                 240 


Glu Lys Tyr Cys Lys Glu Ile Phe Lys Ile Tyr Ser Asn Met Ser Gln 
                245                 250                 255     


Lys Glu Lys Tyr Ser Lys Leu Leu Gly His Arg Asn Gln Gly Ile Ala 
            260                 265                 270         


Ser Ile Tyr Asp Glu Lys Lys Glu Thr Leu Gln Arg Arg Leu Lys Leu 
        275                 280                 285             


Gly Asn Tyr Ser Asp Tyr Asp Leu Arg Lys Tyr Tyr Gln Lys Asp Tyr 
    290                 295                 300                 


Lys Glu Glu Ala Ile Lys Glu Leu Lys Asp Lys Asn Lys Glu Glu Leu 
305                 310                 315                 320 


Glu Arg Glu Ile Glu Glu Leu Ile Lys Lys Asn Tyr Lys Ile Asp Lys 
                325                 330                 335     


Leu Cys Asp Glu Ile Ser Asn Leu Glu Phe Ser Phe Val Glu Ser Lys 
            340                 345                 350         


Lys Glu Asn Lys Asp Lys Met Ser Glu Ile Ile Val Lys Ile Lys Glu 
        355                 360                 365             


His Tyr Lys Lys Asn Val Asn Val Glu Glu Glu Leu Lys Asn Lys Glu 
    370                 375                 380                 


Lys Tyr Ile Leu Ser Leu Ile His Asn Tyr Val Lys Gly Arg Tyr Arg 
385                 390                 395                 400 


Lys Cys Leu Glu Leu Gln Gln Lys Glu Asn Val Asp Phe Glu Asn Leu 
                405                 410                 415     


Gly Lys Arg Ile Lys Asp Ile Phe Asp Ser Asn Glu Val Thr Lys Lys 
            420                 425                 430         


Leu Lys Lys Ser Ile Ile Asn Lys Val Asn Ser Tyr Lys Ile Phe Glu 
        435                 440                 445             


Met Lys Phe Gln Asn Pro Asn Ile Glu Ser Ser Asp Asp Leu Glu Ile 
    450                 455                 460                 


Leu Lys Ala Glu Glu Thr Phe Leu Asn Lys Leu Ser Thr Ala Val Ser 
465                 470                 475                 480 


Lys Val Gly Tyr Thr Leu Asn Ile Leu Leu Gly Val Ser Leu Glu Lys 
                485                 490                 495     


Asp Ile Leu Glu Asn Tyr Asn Met Val Gly Glu Leu Cys Asn Asn Asn 
            500                 505                 510         


Ser Thr Thr Glu Ile Tyr Lys Val Tyr Pro Glu Leu Glu Lys Asn Glu 
        515                 520                 525             


Lys Leu Leu Gln Gly Met Ile His Phe Ile Gln Gly Leu Arg Gln Gln 
    530                 535                 540                 


Ser Leu His Pro Lys Ile Leu Trp Asn Phe Glu Thr Lys Asn Leu Lys 
545                 550                 555                 560 


Ser Glu Lys Leu Glu Arg Leu Lys Glu Lys Lys Asn Ile Lys Met Arg 
                565                 570                 575     


Asp Cys Val Val His Glu Asp Asn Leu Asp Lys Lys Glu Lys Asn Glu 
            580                 585                 590         


Val Glu Ile Lys Lys Tyr Phe Glu Lys Ile Glu Glu Lys Leu Pro Asp 
        595                 600                 605             


Tyr Phe Ile Glu Lys Tyr Glu Ser Asn Asn Val Phe Asn Ile Tyr Arg 
    610                 615                 620                 


Asn Phe Val Asp Lys Ile Met Glu Val Val Lys Asn Phe Asn Phe Lys 
625                 630                 635                 640 


Glu Asn Asn Thr Ile Asp Tyr Leu Phe Pro Lys Phe His Lys Ile Tyr 
                645                 650                 655     


Lys Lys Met Cys Lys Leu Glu Asn Ile Met Cys Lys Ser Glu Asn Ile 
            660                 665                 670         


Asp Asp Arg Gln Asn Gly Ala Arg Lys Tyr Leu Leu Gln Thr Ile Tyr 
        675                 680                 685             


Tyr Tyr Tyr Phe Gln Tyr Glu Ile Glu Asn Asn Lys Asn Asn Ile Phe 
    690                 695                 700                 


Lys Tyr Tyr Arg Asn Ile Gln Arg Glu Gly Met Leu Asn Asn Arg Leu 
705                 710                 715                 720 


Ser Gln Met Asn Asn Glu Trp Ile Glu Phe Ile Val Val Gln Phe Ser 
                725                 730                 735     


Glu Phe Leu Thr Asn Lys Lys Leu Asn Trp Ile Leu Asp Asp Leu Ser 
            740                 745                 750         


Glu Tyr Lys Lys Lys Glu Lys Leu Asp Asn Ser Asp Lys Asp Lys Leu 
        755                 760                 765             


Arg Glu Met Leu Lys Leu Lys Met Asn Lys Lys Leu Ile Tyr Ser Asn 
    770                 775                 780                 


Asp Ser Tyr Val Phe Ile Ser Leu Ala Gln Phe Leu Asp Leu Lys Glu 
785                 790                 795                 800 


Ile Ser Asn Leu Ile His Asp Ile Lys Lys Phe Ile Gln Phe Arg Glu 
                805                 810                 815     


Lys Asn Val Ser Lys Tyr Lys Pro Glu Lys Asn Lys Leu Tyr Ile Glu 
            820                 825                 830         


Glu Leu Lys Lys Ile Leu Tyr Ile Leu Lys Val Met Leu Glu His Lys 
        835                 840                 845             


Glu Arg Val Ile Gln Lys His Tyr Leu Glu Ser Tyr Asp Glu Asn Ile 
    850                 855                 860                 


Ser Ile Met Tyr Gly Lys Asp Ile Glu Lys Lys Asp Ile Lys Asp Ile 
865                 870                 875                 880 


Glu Ile Lys Ile Lys Asn Lys Asn Trp Glu Val Ile Asn Gln Pro Leu 
                885                 890                 895     


Tyr Lys Ser Gly Asn Asp Glu Lys Ser Ser Trp Ile Val Leu Tyr Gly 
            900                 905                 910         


Ile Glu Gln Ala Lys Arg Asn Gly Thr Phe Lys Phe Phe Glu Gly Phe 
        915                 920                 925             


Phe Asn Leu Asn Asp Asp Ile Lys Leu Cys Lys Glu Asn Ile Glu Lys 
    930                 935                 940                 


Tyr Glu Lys Leu Tyr Asn Glu Arg Glu Glu Asn Gln Arg Lys Val Asp 
945                 950                 955                 960 


Glu Tyr Ile Ser Ser Glu Glu Asn Asn Asn Ile Asp Glu Ile Lys Glu 
                965                 970                 975     


Ile Asn Asn Asn Lys Gln Leu Phe Tyr Tyr Tyr Lys Asn Met Ile Tyr 
            980                 985                 990         


Gly Asp Gly Leu Lys Lys Gly Tyr  Asp Phe Ile Asn Asp  Ile Tyr Ser 
        995                 1000                 1005             


His Tyr  Leu Ser Trp Ala Tyr  Arg Ile Glu Arg Asp  Cys Lys Ile 
    1010                 1015                 1020             


Tyr Lys  Ile Lys Lys Tyr Glu  Asn Lys Lys Asn Ser  Asn Glu Tyr 
    1025                 1030                 1035             


Lys Phe  Lys Glu Tyr Lys Ser  Ile Gln Asn Phe Arg  Asn Lys Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Phe Gln  Lys Thr Asp Lys Ser  Leu Leu Asp 
    1055                 1060                 1065             


Leu Leu  Asn Asp Phe Tyr Ser  Ile Phe Asp Tyr Asn  Leu Lys Tyr 
    1070                 1075                 1080             


Gln Arg  Asp Val Gln Lys Val  Ile Asn Asn Ile Phe  Glu Lys Tyr 
    1085                 1090                 1095             


Gln Val  Val Arg Glu Asp Gly  Gly Pro Val Ile Phe  Tyr Cys Lys 
    1100                 1105                 1110             


Val Asp  Lys Lys Leu Lys Leu  Ser Glu Asn Leu Val  Pro Lys Lys 
    1115                 1120                 1125             


His Ser  Lys Tyr Gln Glu Ile  Lys Leu Ile His Glu  Arg Tyr Val 
    1130                 1135                 1140             


Val Phe  Phe Lys Lys Leu Phe  Glu Tyr Lys Lys 
    1145                 1150                 


<210>  703
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  703

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  704
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  704

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Asp Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Thr 
        115                 120                 125             


Lys Asp Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His 
            180                 185                 190         


Glu Arg Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Glu Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Arg 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Lys 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Thr Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Phe Asp Phe Lys Leu  Leu Asn 
    1370                 1375                 1380         


<210>  705
<211>  1177
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  705

Met Gly Thr Gly Lys Tyr Arg Ile Thr Lys Ile Gly Arg Asn Trp Lys 
1               5                   10                  15      


Glu Asn Glu Asn Lys Asn Lys Lys Arg Ile Ile Leu Lys Arg Ile Val 
            20                  25                  30          


Ser Asp Gly Glu Val Lys Tyr Val Asn Glu Asn Asp Asn Val Asp Ile 
        35                  40                  45              


Asp Ile Thr Glu Thr Tyr Tyr Gly Ile Leu Ser Asn Asn Lys Ala Lys 
    50                  55                  60                  


Phe Leu Gly Ser Asn Glu Gln Phe Leu Phe Lys Val Asn Lys Met Asp 
65                  70                  75                  80  


Arg Asn Ile Lys Asn Asp Tyr Val Ile Ile Lys Asp Tyr Thr Glu Glu 
                85                  90                  95      


Glu Phe Glu Lys Phe Asp Lys Lys Ile Phe Phe Ser Arg Lys Ile Lys 
            100                 105                 110         


Ile Asn Asn Glu Asp Arg Glu Lys Ile Cys Arg Asn Phe Tyr Glu Asp 
        115                 120                 125             


Glu Arg Glu Ile Met Lys Lys Arg Leu Glu Glu Ala Lys Asn Phe Asn 
    130                 135                 140                 


Asn Ile Ile Phe Asn Ile Cys Asn Lys Ile Phe Lys Leu Glu Tyr Leu 
145                 150                 155                 160 


Asp Tyr Thr Asp Glu Lys Val Tyr Lys Ile Phe Gln Lys Glu Ile Lys 
                165                 170                 175     


Phe Glu Asp Ile Lys Asn Leu Lys Glu Ala Phe Lys Lys Gln Glu Asn 
            180                 185                 190         


Gly Leu Glu Thr Asp Lys Leu Leu Ala Ile Ser Phe Asn Lys Lys Arg 
        195                 200                 205             


Asn Asn Ile Leu Leu Glu Phe Ile Gln Gln Ile Val Arg Gln Lys Phe 
    210                 215                 220                 


Glu Lys Glu Lys Glu Leu Glu Asn Trp Phe Ser His Glu Gly Glu Lys 
225                 230                 235                 240 


Tyr Cys Lys Glu Ile Phe Lys Ile Tyr Ser Asn Met Ser Gln Lys Glu 
                245                 250                 255     


Lys Tyr Ser Lys Leu Leu Gly His Arg Asn Lys Asn Ile Ala Ser Ile 
            260                 265                 270         


Ser Glu Lys Lys Glu Thr Leu Gln Arg Arg Leu Lys Leu Gly Asn Tyr 
        275                 280                 285             


Ser Asp Tyr Asp Leu Arg Lys Tyr Tyr Gln Lys Asp Tyr Lys Glu Glu 
    290                 295                 300                 


Ala Ile Lys Glu Leu Lys Asp Lys Asn Lys Glu Glu Leu Glu Arg Glu 
305                 310                 315                 320 


Ile Glu Glu Leu Ile Lys Lys Asn Tyr Lys Ile Asp Lys Leu Cys Asp 
                325                 330                 335     


Glu Ile Ser Asn Leu Glu Phe Phe Phe Val Glu Ser Lys Lys Glu Asn 
            340                 345                 350         


Lys Asp Lys Met Ser Glu Ile Ile Val Lys Ile Lys Glu His Tyr Lys 
        355                 360                 365             


Lys Asn Val Asn Val Glu Glu Glu Leu Lys Asn Lys Glu Lys Tyr Ile 
    370                 375                 380                 


Leu Ser Leu Ile His Asn Tyr Val Lys Gly Arg Tyr Arg Lys Cys Leu 
385                 390                 395                 400 


Glu Leu Gln Gln Lys Glu Asn Val Asp Phe Glu Asn Leu Gly Lys Arg 
                405                 410                 415     


Ile Lys Glu Ile Phe Asp Ser Asn Glu Val Thr Lys Lys Leu Lys Lys 
            420                 425                 430         


Ser Ile Ile Asn Lys Val Asn Ser Tyr Lys Ile Phe Glu Met Lys Phe 
        435                 440                 445             


Gln Asn Pro Asn Ile Glu Ser Ser Asp Asp Leu Glu Ile Leu Lys Ala 
    450                 455                 460                 


Glu Glu Thr Phe Leu Asn Lys Leu Ser Thr Ala Val Ser Lys Val Gly 
465                 470                 475                 480 


Tyr Thr Leu Asn Ile Leu Leu Gly Val Ser Ser Glu Glu Asp Ile Leu 
                485                 490                 495     


Lys Asn Tyr Asn Met Val Gly Lys Leu Cys Asn Asn Asn Ser Thr Thr 
            500                 505                 510         


Glu Ile Tyr Lys Val Tyr Pro Glu Leu Glu Lys Asn Glu Lys Leu Leu 
        515                 520                 525             


Gln Gly Met Ile His Phe Ile Gln Gly Leu Arg Gln Gln Ser Leu His 
    530                 535                 540                 


Pro Lys Ile Ser Trp Asn Phe Glu Thr Glu Asn Leu Lys Pro Glu Lys 
545                 550                 555                 560 


Leu Glu Arg Leu Lys Glu Lys Lys Asn Ile Lys Ile Arg Asp Cys Val 
                565                 570                 575     


Val His Glu Tyr Asn Leu Asp Lys Lys Glu Lys Asn Glu Val Glu Ile 
            580                 585                 590         


Lys Glu Tyr Phe Glu Lys Ile Glu Lys Lys Leu Pro Asn Tyr Phe Ile 
        595                 600                 605             


Glu Lys Tyr Glu Ser Asn Asn Val Phe Asn Ile Tyr Arg Asp Ser Val 
    610                 615                 620                 


Asp Lys Ile Met Glu Val Val Lys Lys Phe Asn Phe Lys Glu Asp Asn 
625                 630                 635                 640 


Thr Ile Asp Tyr Leu Phe Pro Lys Phe His Lys Ile Tyr Lys Lys Met 
                645                 650                 655     


Cys Lys Leu Glu Asn Ile Thr Cys Lys Ser Glu Asn Thr Asp Asp Arg 
            660                 665                 670         


Gln Asn Gly Ala Arg Lys Tyr Leu Leu Gln Thr Ile Tyr Tyr Tyr Tyr 
        675                 680                 685             


Phe Gln Tyr Glu Ile Glu Asn Asn Arg Asn Asn Ile Phe Lys Tyr Tyr 
    690                 695                 700                 


Arg Asn Lys Ile Lys Thr Glu Lys Asn Ser Tyr Arg Asp Lys Asn Ile 
705                 710                 715                 720 


Glu Ile Leu Tyr Arg Asn Ile Gln Arg Glu Gly Met Leu Asn Asn Arg 
                725                 730                 735     


Leu Leu Gln Met Asn Asn Glu Trp Ile Glu Phe Ile Met Ile Gln Phe 
            740                 745                 750         


Ile Glu Phe Ile Ser Ile Lys Lys Leu Asn Trp Ile Leu Asp Asp Leu 
        755                 760                 765             


Ser Glu Tyr Arg Lys Lys Glu Lys Leu Asp Glu Asn Asp Lys Asn Arg 
    770                 775                 780                 


Leu Leu Lys Ile Leu Lys Gln Lys Met Asn Lys Asn Ile Thr Tyr Ser 
785                 790                 795                 800 


Asn Asp Ser Tyr Val Phe Ile Ser Leu Ala Gln Phe Leu Asp Leu Lys 
                805                 810                 815     


Glu Ile Ser Asn Leu Ile His Asp Ile Lys Lys Phe Val Gln Phe Arg 
            820                 825                 830         


Glu Lys Asn Ile Ser Lys Tyr Lys Pro Glu Lys Asn Lys Val Tyr Ile 
        835                 840                 845             


Glu Glu Leu Arg Lys Ile Ser Tyr Ile Leu Lys Val Met Leu Glu His 
    850                 855                 860                 


Lys Glu Arg Val Ile Gln Lys His Tyr Leu Glu Ser Tyr Asp Glu Asp 
865                 870                 875                 880 


Ile Ser Ile Met Tyr Gly Lys Asp Ile Glu Lys Lys Asp Ile Lys Asp 
                885                 890                 895     


Ile Glu Ile Lys Ile Lys Asn Lys Asn Gln Glu Val Ile Asn Gln Pro 
            900                 905                 910         


Leu Tyr Lys Ser Gly Asn Asp Gly Asn Ser Ser Trp Ile Val Leu Tyr 
        915                 920                 925             


Gly Ile Glu Gln Ala Lys Arg Asn Gly Thr Phe Lys Phe Phe Glu Gly 
    930                 935                 940                 


Phe Phe Asn Leu Asn Glu Asp Ile Lys Leu Cys Lys Lys Asp Ile Lys 
945                 950                 955                 960 


Lys Tyr Glu Lys Leu Tyr Asn Glu Lys Glu Glu Asn Gln Lys Lys Val 
                965                 970                 975     


Asp Glu Tyr Ile Phe Tyr Glu Arg Asn Ser Tyr Ile Glu Lys Val Asn 
            980                 985                 990         


Asn Asn Ile Asn Ile Glu Lys Thr  Asn Asn Asn Lys Gln  Leu Phe Tyr 
        995                 1000                 1005             


Tyr Tyr  Lys Asn Met Ile Tyr  Gly Asp Gly Leu Lys  Lys Gly Tyr 
    1010                 1015                 1020             


Asp Phe  Ile Asn Asp Ile Tyr  Ser His Tyr Leu Ser  Trp Ala Tyr 
    1025                 1030                 1035             


Arg Ile  Glu Arg Asp Cys Lys  Ile Tyr Lys Ile Lys  Glu Tyr Glu 
    1040                 1045                 1050             


Asn Lys  Lys Asn Phe Asn Glu  Tyr Lys Phe Lys Glu  Tyr Lys Ser 
    1055                 1060                 1065             


Ile Lys  Asn Phe Arg Asn Glu  Ile Ala His Phe Asn  Tyr Phe Gln 
    1070                 1075                 1080             


Lys Thr  Asn Lys Ser Leu Leu  Glu Leu Leu Asn Asn  Phe Tyr Asp 
    1085                 1090                 1095             


Ile Phe  Asp Tyr Asn Leu Lys  Tyr Gln Arg Asp Val  Gln Lys Val 
    1100                 1105                 1110             


Ile Asn  Asn Ile Phe Glu Lys  Tyr Gln Val Ile Arg  Glu Asp Gly 
    1115                 1120                 1125             


Gly Pro  Val Ile Phe Tyr Cys  Lys Ile Glu Lys Lys  Leu Lys Leu 
    1130                 1135                 1140             


Ser Glu  Asn Ile Ile Pro Lys  Lys His Ser Lys Tyr  Pro Glu Ile 
    1145                 1150                 1155             


Lys Leu  Ile His Glu Lys Tyr  Val Glu Phe Phe Lys  Lys Leu Phe 
    1160                 1165                 1170             


Glu Tyr  Lys Lys 
    1175         


<210>  706
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  706

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Ser Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Val Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Thr Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Lys Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Val Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Lys Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Lys Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Val Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Leu Lys Glu Leu Lys Glu Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn Tyr Arg Met Gln Gln Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Lys Lys Asp Glu Lys Phe Asn Asp Lys Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Thr Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Glu Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Lys  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  707
<211>  1389
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  707

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Lys Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn Gln Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Ile Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Asn Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Val Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Phe Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Gln Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Lys Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asp Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Val 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Met Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Cys Ile  Ser Ser Ile Lys Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Thr Leu Ile Thr Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Leu Leu Tyr  Tyr Pro Asp 
    1310                 1315                 1320             


Ile Glu  Ser Asn Val Lys Ile  Leu Leu Arg Lys Asp  Asn Phe Asn 
    1325                 1330                 1335             


Gln Asn  Lys Asp Lys Lys Asn  Val Asn Asn Arg Lys  Thr Lys Asn 
    1340                 1345                 1350             


Asn Asn  Lys Asn Gly Asn Arg  Asn Arg Asp Lys Asn  Arg Asp Lys 
    1355                 1360                 1365             


Asn Gly  Gly Gly Asp Gly Leu  Thr Tyr Asn Pro Phe  Leu Asn Leu 
    1370                 1375                 1380             


Ile Phe  Asp Leu Pro Glu 
    1385                 


<210>  708
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  708

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Asp Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Thr 
        115                 120                 125             


Lys Asp Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His 
            180                 185                 190         


Glu Arg Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Glu Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Arg 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Lys Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  709
<211>  1373
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  709

Met Ala Lys His Leu Arg Pro Ile Gly Glu Ser Tyr Thr Asp Phe Leu 
1               5                   10                  15      


Asp Glu Thr Glu Phe Val Arg Leu Gly Arg Gly Leu His Arg Gly His 
            20                  25                  30          


His Gly Val Gln Ile Pro Pro Thr Glu Leu Pro Ser Tyr Leu Ala Glu 
        35                  40                  45              


Tyr Arg Lys Ala Leu Met Arg Gln Val Val Ala Val Leu Asp Lys Val 
    50                  55                  60                  


Val Gly Lys Arg Arg Arg Leu Ser Gly Met His Pro Glu Ala Tyr Arg 
65                  70                  75                  80  


Asp Arg Val His Leu Ala Glu Ala Leu Trp Val Arg Leu Val Ala Arg 
                85                  90                  95      


Val Lys Glu Ile Gly Thr Pro Pro Asp Pro Ser Glu Leu Leu Asp Leu 
            100                 105                 110         


Arg Arg Met Trp Asn Ala Lys Ala His Pro Tyr Ala Glu Tyr Asp Val 
        115                 120                 125             


Val Pro Arg Ala Pro Leu Asn Asp Gly Asn Gly Gln Lys Ile Leu Glu 
    130                 135                 140                 


Cys Arg Glu Val Asp Asp Pro Lys Ile Glu Arg Ser Asp Phe Glu Gly 
145                 150                 155                 160 


Arg Trp His Gly Arg Phe Trp Gln Ser Glu Pro Gly Pro Val Asp Tyr 
                165                 170                 175     


Asn Ala Ile Ala Asp Arg Ile Phe Ala His Leu Phe Asp Gln Glu Ala 
            180                 185                 190         


Val Ile Gly Gly Gly Pro Arg Arg Glu Gly Asn Val Thr Val Pro Asp 
        195                 200                 205             


Glu Asp Ile Asn Gly Gln Pro Gly Pro Ala Thr Gly Lys Gly Leu Ile 
    210                 215                 220                 


Ile Ala Arg Gly Gln Ser Ile Val Lys Ser Ala Ser Asp Pro Arg Arg 
225                 230                 235                 240 


Ser Ser Lys Lys Val Gln Arg Thr Trp Asp Lys Ala Val Glu Arg Arg 
                245                 250                 255     


Tyr Phe Gly Asp Asp Gly Lys Gly Gly Ser Asp Ile Ala Lys Ala Ile 
            260                 265                 270         


Tyr Glu Glu Leu Gly Asp Pro Ala Thr Leu Ala Asp Pro Ile Tyr Ala 
        275                 280                 285             


Ser Trp Phe Gly Ser Arg Leu Tyr Asp His Phe Gly Ser Phe Lys Asn 
    290                 295                 300                 


Ser Leu Pro Leu Glu Leu Lys Asp Pro Phe Lys Glu Gln Ile Trp Ala 
305                 310                 315                 320 


Leu His Asn Ser Val Arg Gln Phe Tyr Gln Arg Met Ala Lys Ser Asp 
                325                 330                 335     


Arg Phe Arg Leu Ala Leu Gln Asn Ala Arg Ser Glu Val Pro Asp Arg 
            340                 345                 350         


Ser Glu Leu Leu Ala Leu Leu Pro Lys Asp His Asp His Leu Leu Leu 
        355                 360                 365             


Val Leu Gly Gly Lys Lys Lys Asn Ala Glu Met Ser Glu Leu Ile Arg 
    370                 375                 380                 


Leu Gly Lys Leu Phe Val His Ala Ser Asp Val Leu His Asp Phe Asp 
385                 390                 395                 400 


Ala Asn Asp Ala Ala Ala Leu Asp Ala Phe Lys Arg Arg Met Ser Phe 
                405                 410                 415     


Leu Ala Thr Ser Ile Gly Gln Ser Glu Ile Lys Gln Thr Glu Thr Phe 
            420                 425                 430         


Ala Arg Thr Trp Arg Gly Ala Val Gly Leu Thr Leu Arg Thr Val Lys 
        435                 440                 445             


Gly Leu Ala Asp Pro Arg Gly Ile Ile Gly Thr Pro Asp Asn Arg Asp 
    450                 455                 460                 


Leu Gly Thr Ala Gly Pro Met Lys Asp Ala Phe Asn Lys Phe Asp Gln 
465                 470                 475                 480 


Pro His Phe Gln Gln His Met Thr Ile Ile Phe Gly Asn Lys Glu Leu 
                485                 490                 495     


Gln Ala Glu Gly Asn Pro Thr Arg Ser Ser Val Phe Thr Ala Asn Gly 
            500                 505                 510         


Asp Lys Asp His Gln Ala Glu Leu Leu Trp Gly Phe Leu Cys Val Val 
        515                 520                 525             


Arg Ser Val Arg Asn Arg Thr Asn His Tyr Asn Val Arg Arg Ala Leu 
    530                 535                 540                 


Leu Arg Leu Leu Asp Glu Gly Ile Val Ser Pro Met Pro Ser Asp Pro 
545                 550                 555                 560 


Lys Lys Glu Arg Val Glu Asn Arg Asn Leu Cys Thr Val Ser Pro Thr 
                565                 570                 575     


Ala Leu Glu Ala Phe Arg Arg Leu Leu Asn Phe Asp Leu Ala Ile Gln 
            580                 585                 590         


Lys Glu Ala Val Arg Thr Ala Leu Glu Gln Ala Lys Ala Ser Glu Phe 
        595                 600                 605             


Val Glu Glu Gly Lys Leu Arg Gly Leu Val Ser Glu Leu Ala Gly Thr 
    610                 615                 620                 


Glu Asp Met Pro Ala Leu His Ile Pro Arg Phe Ser Ala Val Met Asp 
625                 630                 635                 640 


Lys Val Arg Arg Leu Ala Asp Asn Arg Asp Val Gly Leu Asp Pro Ile 
                645                 650                 655     


Leu Ser Thr Leu Gln Arg Ser Leu Pro Pro Thr Asp Lys Gln Ala Glu 
            660                 665                 670         


Ser Asp Ala Ala Arg Cys Arg Tyr Arg Leu Leu Leu Glu Leu Tyr Lys 
        675                 680                 685             


Ser Gly Phe Arg Ser Trp Phe Ser Gly Ile Gln Ser Asn Glu Glu Asn 
    690                 695                 700                 


Asn Arg Glu Ile Cys His Trp Ala Val Lys Gln Val Gly Arg Ala Lys 
705                 710                 715                 720 


Asp Ala Arg Lys Ser Glu Tyr Asp Lys Lys Thr Lys Arg His Tyr Arg 
                725                 730                 735     


Ser Pro Asn Ser Leu Ile Asp Asp Leu Gly Leu Asp Lys Phe Asp Asp 
            740                 745                 750         


Leu Thr Asp Leu Leu Glu Ala Leu Ala Ser Gln Ser Thr Arg Glu His 
        755                 760                 765             


Asp Gln Asn Leu Lys Tyr Val Pro Asp Ala Arg Val Gln Ser Gln Met 
    770                 775                 780                 


Ser Asn Arg Ile Glu Glu Phe Arg Gln Glu Leu Phe Ala His Ile Phe 
785                 790                 795                 800 


Thr Lys Tyr Leu Asp Thr His Asp Phe Gly Trp Ile Gly Ala Ile Glu 
                805                 810                 815     


Val Arg Arg Glu Ala Cys Asp Leu Ala Asp Val Val Ser Ala Phe Glu 
            820                 825                 830         


Val Arg Asp Gln Lys Phe Asp Ala Asp Trp His Ser Gln Phe Tyr Ala 
        835                 840                 845             


Trp Leu Tyr Met Val Pro Pro Ile Glu Ala Ser Arg Leu Arg His Gln 
    850                 855                 860                 


Met Arg Lys Ser Ala Val Met Asp Asp Lys Trp Ser Thr Thr Leu Glu 
865                 870                 875                 880 


Leu Thr Ser Gly Asp Arg Lys Thr Arg Asp Asp His Ala Gln Asp Val 
                885                 890                 895     


Leu Ala Asp Met Asp Arg Leu Phe Ser Leu Tyr Thr Lys Val Gln Ala 
            900                 905                 910         


Ala Gly Phe Asn Gly Gln Glu His Glu Ser Ala Leu Gly Ser Lys Ser 
        915                 920                 925             


Leu Phe Tyr Glu Asp Gly Asn Gln Phe Asp Glu Val Tyr Ser Pro Asp 
    930                 935                 940                 


Thr Glu Thr His Asn Lys Thr Phe Pro Gly Thr Arg Arg Gly Leu Arg 
945                 950                 955                 960 


Gln Leu Val Arg Tyr Ala His Leu Pro Ala Leu Glu Gly Val Phe Lys 
                965                 970                 975     


Lys His Arg Ile Thr Lys Ala Glu Val Glu Thr Phe Val Ala Leu Tyr 
            980                 985                 990         


Asp Glu Asn Arg Arg Asp Pro Gly  Ser Val Ala His Met  Leu Arg Arg 
        995                 1000                 1005             


Glu Lys  Leu Arg Thr Glu Ile  Leu Arg Ser Ile His  Asp Gly Pro 
    1010                 1015                 1020             


Lys Pro  Lys Asp Lys Asp Phe  Trp Pro Lys Leu Glu  Ala Lys Cys 
    1025                 1030                 1035             


Leu Glu  Tyr Arg Thr Val Ala  Thr Glu Thr Ala Ile  Tyr Asn Phe 
    1040                 1045                 1050             


Gln Ala  Asn Ala Ala Arg Leu  Asn Asp His Ala Arg  Leu His Gln 
    1055                 1060                 1065             


Ile Val  Met Arg Val Val Ala  Arg Leu Thr Asp Tyr  Ala Leu Ile 
    1070                 1075                 1080             


Trp Glu  Arg Asp Arg Leu Phe  Ala Phe Val Gly Met  Leu Tyr Arg 
    1085                 1090                 1095             


Gln Thr  Gly Gly Thr Gly Ile  Asn Pro Ala Met Arg  His Ala Glu 
    1100                 1105                 1110             


Lys Thr  Asn Ala Pro Pro Arg  Ile Gly Ile Leu Val  Ser Asp Ser 
    1115                 1120                 1125             


Ala Leu  Ala Lys Lys Leu Asn  Ser Asn Ser Ala Glu  Val Phe Ile 
    1130                 1135                 1140             


Pro Tyr  Leu Asp Thr Glu Thr  Gly Phe Asp Ala Pro  Arg Phe Asp 
    1145                 1150                 1155             


Asp Leu  Cys Thr Leu Leu Ser  His Glu His Ala Lys  Glu Phe Arg 
    1160                 1165                 1170             


Phe His  Phe Leu Glu Val Gly  Glu Glu Asn Ser Lys  Asp Glu Ala 
    1175                 1180                 1185             


Arg Arg  Leu Asn Glu Glu Thr  Met Gly His Arg Lys  Arg Pro Ala 
    1190                 1195                 1200             


Phe Lys  Arg Gly Thr Arg Arg  Gln Gly Ile Arg Asn  Asp Leu Ala 
    1205                 1210                 1215             


His His  Asn Val Leu Asp Leu  Ala Gly Gly Ala Gly  Pro Asn Leu 
    1220                 1225                 1230             


Thr Tyr  Val Val Asn Ala Val  Arg Ser Leu Leu Ser  Tyr Asp Arg 
    1235                 1240                 1245             


Lys Leu  Lys Asn Ala Val Pro  Lys Ser Ile Lys Arg  Ile Leu Gly 
    1250                 1255                 1260             


Glu Glu  Gly Leu Ile Ile Glu  Trp Gln Met Asn Tyr  Asp Arg Leu 
    1265                 1270                 1275             


Lys Lys  Pro Thr Val Tyr Pro  Asn Val Glu Thr His  Leu Thr Met 
    1280                 1285                 1290             


Val Pro  Pro Arg His Met Thr  Ala Pro Val Ser Phe  Thr Leu Pro 
    1295                 1300                 1305             


Arg Ala  Ser Val Arg Leu Ala  Ser Met Val Lys Ala  Val Phe Asp 
    1310                 1315                 1320             


Phe Gly  Ser Ser Gly Tyr Gly  Glu Glu Arg Met Ile  Gly Gly Arg 
    1325                 1330                 1335             


Thr Ala  Lys Gln Ala Val Tyr  Pro Asp Asp Phe Thr  Arg Arg Phe 
    1340                 1345                 1350             


Pro Gln  Thr Pro Met Gly Leu  Lys Gln Ala Thr Arg  Leu Val Phe 
    1355                 1360                 1365             


Ala Ser  Glu Asn Ser 
    1370             


<210>  710
<211>  1287
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  710

Met Arg Ile Gly Lys Val Gln Gly Arg Thr Phe Thr Gly Phe Asp Asn 
1               5                   10                  15      


Ala Arg Gly Lys Thr Leu Arg Arg Arg Leu Leu Thr Arg Pro Asp Asn 
            20                  25                  30          


Glu Ala Arg Ser Leu Ser Glu His Leu Ala His Asp Pro Lys Ala Leu 
        35                  40                  45              


Ile Gly Gln Ala Ile Ser Arg Ile Asp Thr Ile Tyr Gln Lys Pro Lys 
    50                  55                  60                  


Thr Gly Lys Pro Thr Pro Glu Gln Phe Gly His Arg Asp Thr Leu Gly 
65                  70                  75                  80  


Trp Ala Tyr Trp Lys Leu Leu Val Ala Ser Tyr Pro Glu Val Glu Gly 
                85                  90                  95      


His Arg Asp Leu Phe Val Arg Arg Leu His Pro Tyr Gly Asp Thr Pro 
            100                 105                 110         


Pro Lys Ser His Gly Gln Lys Glu Gly Glu His Gln Lys Gly Gly Lys 
        115                 120                 125             


Pro Gln Leu Glu Gly Arg Trp His Gly Val Met Ala Gln His Gly Lys 
    130                 135                 140                 


Asn Pro Asp Gln Ile Ala Ala Arg Leu Phe Asp His Leu His Asn Ser 
145                 150                 155                 160 


Glu Leu Arg Phe Gly Gly Thr Ala Ser Gly Glu Pro Arg Thr Arg Pro 
                165                 170                 175     


Gly Lys Glu Ala Thr Pro Thr Gly Leu Ile Gly Ala Arg Ala Lys Thr 
            180                 185                 190         


Ile Glu His Ser Val Leu Pro Arg Asp Ala Lys Arg Phe Val Ala Glu 
        195                 200                 205             


Trp Arg Gly Glu Asp Gln Glu Arg Tyr Ala Gly Ala Arg Asp Ile Ala 
    210                 215                 220                 


Ala Ala Ile Ser Ala Gly Leu Asn Asp Lys Asp Gln Lys Ser Gly Ser 
225                 230                 235                 240 


Gly Arg Lys Ser Ala Val Ile Gly Lys Leu Leu Ser Asp His Leu Glu 
                245                 250                 255     


Thr Leu Thr Gly Asn Arg Lys Cys Arg Phe Asp Pro Lys Ser Thr Ala 
            260                 265                 270         


Glu Thr Leu Glu Leu Arg Asp Gly Glu Ser Val Asp Asp Arg Arg Arg 
        275                 280                 285             


Ile Leu Glu Leu His Ala Glu Val Lys Ala Thr Tyr Lys Arg Met Ala 
    290                 295                 300                 


Ala Trp Lys Pro Ala Lys Leu Pro Arg Asn Ser Asp Glu Leu Phe Arg 
305                 310                 315                 320 


Leu Val Arg Gln Gln Ala Asp Asn Arg Ile Leu Asn His Leu Val Arg 
                325                 330                 335     


Val Gly Arg Ile Ser Val Tyr Ser Glu Gln Ser Asp Ala Leu Ser Glu 
            340                 345                 350         


Ser Gln Phe Trp Thr Ser Gly Gly Gln Thr Gln Ile Lys Glu Ser Glu 
        355                 360                 365             


Val Phe Ala Arg Leu Trp Ile Gly Ala Ile Ser Arg Ala Ser Tyr Ser 
    370                 375                 380                 


Met Lys Ala Trp Leu Glu Pro Glu Gly Thr Val Phe Asn Pro Ser Ile 
385                 390                 395                 400 


Asn Asp Phe Asp Val Thr Ser Ser His Asn Thr Asn Arg Ile Leu Glu 
                405                 410                 415     


Asp Ser Gly Arg Leu Ser Asn Ala Met Ala Arg Arg Ala Ile Tyr Phe 
            420                 425                 430         


Gly Glu Thr Pro Glu Phe Asp Ala Leu Gly Glu Glu Asp Gln Arg Val 
        435                 440                 445             


Leu Val Lys Lys Cys Leu Asp Ala Leu Ser Ala Cys Arg Asn Arg Thr 
    450                 455                 460                 


Phe His His Gly Gln Arg Ala Lys Phe Leu Lys Glu Val Arg Lys Gly 
465                 470                 475                 480 


Leu Lys Glu Lys Glu Ala Asp Ser Ala Gly Pro Ala Ala Trp Glu Gly 
                485                 490                 495     


Ile Arg Glu Val Ile Gln Ala Asp Ala Arg Asn Leu Gly Ala Arg Leu 
            500                 505                 510         


Leu Gln Asp Leu Thr Gly Ala Lys Val His Ser Phe Ala Thr Asp Pro 
        515                 520                 525             


Glu Phe Arg His Leu Tyr Glu Ser Val Ala Ala Thr Leu Thr Ala Gly 
    530                 535                 540                 


Gly Glu Leu Glu Ala Ala Leu Pro Arg Leu Lys Asn Val Leu Lys Arg 
545                 550                 555                 560 


Ala Glu Gly Val Arg Cys Tyr Leu Asp Thr Pro Ser Gln Arg Arg Glu 
                565                 570                 575     


Gly Asp Glu Ser Leu Ile Ala Arg Leu Pro Val Ala Pro Val Pro Arg 
            580                 585                 590         


Glu Leu Asp Asp Ala Ala Thr Lys Ala Arg His Ser Ala Leu Leu Arg 
        595                 600                 605             


Leu Tyr Asp Gly Pro Phe Arg Pro Trp Ala Thr Glu Leu Arg Gly Glu 
    610                 615                 620                 


Arg Leu Ser Asp Tyr Ala Ala Arg Ala Lys Arg Leu Ala Thr Arg Leu 
625                 630                 635                 640 


Ala Lys Ser Thr Asn Thr Ala Ser Pro Tyr Pro Asp Ser Val Glu Gly 
                645                 650                 655     


Arg Ser Val Arg Leu Arg Asp Pro Ile Thr Ala Asp Thr Ala Pro Glu 
            660                 665                 670         


Thr Leu Lys Thr Tyr Leu Ser Ala Leu Thr Ala Glu Thr Ala Thr Glu 
        675                 680                 685             


Phe Arg Val Gln Lys Gly Tyr Glu Ser Asp Gly Glu Lys Ala Lys Glu 
    690                 695                 700                 


Gln Ala Glu Phe Ile Glu Asp Phe Arg Arg Asp Met Ile Ala Leu Ala 
705                 710                 715                 720 


Phe Gln Asp Phe Ile Arg Asp His Gly Phe Ala Trp Leu Leu Asp Ile 
                725                 730                 735     


Ala Ser Lys Ala Glu Pro Ser Asn Asp Ala Pro Asn Leu Pro Asp Pro 
            740                 745                 750         


Val Asp Thr Gly Lys Asp Thr Val Phe Glu Asp Trp Gln Ala Leu Leu 
        755                 760                 765             


Tyr Leu Phe Leu His Phe Val Pro Ala Asp Asp Val Ser Gln Leu Leu 
    770                 775                 780                 


His Gln Leu Arg Lys Trp Asp Ala Leu Gln Asp Lys Tyr Glu Leu Ala 
785                 790                 795                 800 


Glu Pro Gly Glu Thr Leu Gly Gln Thr Lys Ala Asp Thr Arg Lys Ile 
                805                 810                 815     


Val Gly Gln Phe Arg Asp Cys Leu Thr Leu Phe Leu Lys Thr Gly Asp 
            820                 825                 830         


Ala Arg Phe Asp Gly Glu Gly Val Glu Leu Pro Leu Ser Asp Phe Gln 
        835                 840                 845             


Glu Leu Phe Glu Ser Pro Ala Thr Phe Lys Glu Leu Phe Leu Ala Glu 
    850                 855                 860                 


Pro Ala Glu Asn Asp Ala Ser Glu Thr Asp Asp Gln Asp Ala Pro Gly 
865                 870                 875                 880 


Glu Lys His Arg Val Thr Arg Thr Arg Arg Gly Leu Arg Gln Ile Leu 
                885                 890                 895     


Arg Tyr Asn His Met Pro Val Leu Arg Asp Leu Phe Leu Ala His Lys 
            900                 905                 910         


Val Thr Asp Ala Glu Val Asp Gly Leu Gln Ala Leu Glu Val Asp Asp 
        915                 920                 925             


Pro Gln Thr Gly Glu Ser Gln Ile Gly Ala Ala Gln Arg Ile Arg Thr 
    930                 935                 940                 


Glu Ile His His His Thr Ser Asn Asp Lys Gln Ile Ser Glu Ala Lys 
945                 950                 955                 960 


Val Glu Glu Tyr Arg Arg Ala Leu Ser Thr Ile Glu Arg His Arg Phe 
                965                 970                 975     


Leu Val Gly Arg Val Tyr Leu Gly Asp His Ile Arg Val His Lys Leu 
            980                 985                 990         


Met Met Asp Val Met Gly Arg Leu  Val Asp Phe Ala Gly  Ala Trp Glu 
        995                 1000                 1005             


Arg Glu  Ala Ala Asp Gly Asp  Arg Lys Gly Phe Ile  Ser Arg Ala 
    1010                 1015                 1020             


Ile Ala  Leu Pro Glu Val Ala  Glu Gly Tyr Ala Ala  Asp Arg Leu 
    1025                 1030                 1035             


Lys Thr  Val Ala Arg Arg Val  Leu Asp Asp Gly Glu  Ala Arg Arg 
    1040                 1045                 1050             


Ile Arg  Asn Asp Leu Gly His  Phe Asn Asp Leu Ala  Pro Thr Ser 
    1055                 1060                 1065             


Gly Pro  Ala Asn Leu Thr Phe  Val Val Asn Arg Ala  Arg Arg Met 
    1070                 1075                 1080             


Met Arg  His Asp Arg Lys Arg  Lys Asn Ala Val Thr  Lys Ser Val 
    1085                 1090                 1095             


Ile Glu  Ile Leu Asn Arg Gln  Gly Leu Gly Ile Glu  Trp Thr Met 
    1100                 1105                 1110             


Arg Asn  His Glu Leu Cys Glu  Ala Lys Leu Trp Gln  Asn Pro Val 
    1115                 1120                 1125             


Lys His  Leu Gly Phe Ala Thr  Leu Glu Gly Arg Gly  Lys Lys Trp 
    1130                 1135                 1140             


Arg Arg  Pro Phe Glu Ala Arg  Tyr Gly Asp Ala Tyr  Met Ala Met 
    1145                 1150                 1155             


Val Ala  Gln Leu Phe Asp Gly  Thr Val Thr Ser Pro  Pro Ala Lys 
    1160                 1165                 1170             


Gly Pro  Pro Gln Ser Gly Lys  Ser Gly Gly Lys Pro  Gly Lys Gly 
    1175                 1180                 1185             


Ala Glu  Gly Gly Ala Lys Glu  Lys Ser Arg Ser Pro  Thr Arg Met 
    1190                 1195                 1200             


Glu Glu  Gly Gly Val Tyr Glu  Gly Arg Val Ala Lys  Ala Lys Ser 
    1205                 1210                 1215             


Asp Lys  Gly Phe Gly Phe Leu  Leu Val Glu Gly Ala  Gln Glu Glu 
    1220                 1225                 1230             


Ile Phe  Leu His Ile Tyr Gly  Ile Ser Gly Asn Arg  Pro Ala Arg 
    1235                 1240                 1245             


Ile Glu  Asn Gly Gln Arg Tyr  Arg Phe Thr Leu Gly  Ile Asp Arg 
    1250                 1255                 1260             


Asp Arg  Glu Arg Arg Lys Glu  Arg Ala Trp Val Ala  Arg Glu Ala 
    1265                 1270                 1275             


Val Arg  Ile Asp Glu Asn Arg  Ser Lys 
    1280                 1285         


<210>  711
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  711

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Gly Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asp 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  712
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  712

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Asp Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His 
            180                 185                 190         


Glu Arg Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Asp Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Ser Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val His Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  713
<211>  1165
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  713

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  
    1160                 1165 


<210>  714
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  714

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Pro Gly Thr Asp Thr 
            20                  25                  30          


Ile Gly Leu Lys Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Asp Lys Pro Lys Lys 
    50                  55                  60                  


Trp Lys Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Glu Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Ser Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Met Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Tyr Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ser Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Gln Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Phe 
            660                 665                 670         


Ile Arg Lys Asn Phe Pro Glu Asp Ile Ser Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val Tyr Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Asp Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Asp Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asn  Ser Glu Lys Lys Glu  Ala Tyr Gln Lys Ile  Glu Val Asn 
    1100                 1105                 1110             


Gly Asp  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Val  Tyr Ala Pro Asp Glu  Lys Gly Asp 
    1130                 1135                 1140             


Ile Leu  Lys Glu Gln Cys Thr  Lys Gly Gly Ala Gly  Gly Lys Ile 
    1145                 1150                 1155             


Ser Ala  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Lys Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Lys Gln 
    1250                 1255                 1260             


Thr Thr  Ser Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Ser Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Lys  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Val Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Gly Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Pro Asn 
    1370                 1375                 1380         


<210>  715
<211>  1119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  715

Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu Asp Asp Glu Lys Arg 
1               5                   10                  15      


Ala Glu Ile Leu Arg Lys Leu Arg Arg Ile Leu Asp Val Tyr Phe Ser 
            20                  25                  30          


Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile Thr Leu Ser Asp Asn 
        35                  40                  45              


Ile Asp Lys Glu Lys Phe Asn Val Trp Lys Lys Tyr Glu Cys Gly Lys 
    50                  55                  60                  


Lys Val Thr Asp Leu Phe Val Asp Ile Pro Asp Val Leu Met Glu Ala 
65                  70                  75                  80  


Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val Glu Lys Arg Glu Arg 
                85                  90                  95      


Lys Val Leu Ala Asp Arg Val Arg Arg Gln Asn Ile Ile Cys Tyr Arg 
            100                 105                 110         


Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser Asn Glu Ser Leu Phe 
        115                 120                 125             


Phe Glu Asn Asp Ala Ile Asn Gln Tyr Trp Ile His His Ile Glu Asn 
    130                 135                 140                 


Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala Gly Lys Leu Phe Lys 
145                 150                 155                 160 


Leu Arg Met Gly Tyr Leu Ala Glu Lys Val Trp Lys Asp Ala Ile Asn 
                165                 170                 175     


Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys Ala Val Tyr Asn Phe 
            180                 185                 190         


Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asp Lys Glu Leu Gly Ile 
        195                 200                 205             


Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser Phe Asp Tyr Glu Met 
    210                 215                 220                 


Ile Lys Ala Tyr Glu Asn Leu Gln Arg Glu Leu Ser Val Asp Ile Ala 
225                 230                 235                 240 


Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys Asp Met Ser Asn Leu 
                245                 250                 255     


Lys Asp Arg Glu Ser Asp Phe Leu Leu Trp Lys Lys Glu Asp Ile Ala 
            260                 265                 270         


Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser Val Ser Ala Val Leu 
        275                 280                 285             


Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile Asn Ile Phe Lys Glu 
    290                 295                 300                 


Ala Tyr Lys Gly Lys Asn Lys Tyr Asn Tyr Glu Val Arg Phe Ile Asp 
305                 310                 315                 320 


Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn Glu Asn Phe His Phe 
                325                 330                 335     


Lys Thr Ala Leu Val Asn Asn Glu Lys Trp Asn Thr Glu Leu Phe Gly 
            340                 345                 350         


Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu Asn Val Glu Lys Asp 
        355                 360                 365             


Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr Pro Val Ser Glu Leu 
    370                 375                 380                 


Arg Asn Met Leu Asp Gln Leu Tyr Ser Arg Ser Val Ser Arg Ala Ala 
385                 390                 395                 400 


Gln Val Pro Ser Tyr Asn Ser Val Phe Ile Arg Lys Asn Phe Pro Glu 
                405                 410                 415     


Asp Ile Thr Asn Val Leu Arg Tyr Gln Lys Pro Gly Tyr Asp Ala Asp 
            420                 425                 430         


Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu Leu Lys Glu Ile 
        435                 440                 445             


Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Lys Ala Leu Gln Leu Phe Glu 
    450                 455                 460                 


Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Glu Glu Gln Lys Arg Ala 
465                 470                 475                 480 


Val Asp Asn Phe Lys Asn His Phe Ser Asp Ile Lys Ser Ala Cys Thr 
                485                 490                 495     


Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr Glu Tyr Asn Gln Gln 
            500                 505                 510         


Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn Asp Ser Ile Phe Asp 
        515                 520                 525             


Gln Pro Ile Tyr Gln His Tyr Lys Val Leu Leu Lys Lys Ala Ile Ala 
    530                 535                 540                 


Asn Ala Phe Ala Ala Tyr Leu Lys Asn Asn Lys Asp Leu Phe Gly Phe 
545                 550                 555                 560 


Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg Glu Ile Asp Lys Glu 
                565                 570                 575     


Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr Glu Ser Leu Cys Ile 
            580                 585                 590         


Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp Tyr Ile Val Gly Lys 
        595                 600                 605             


Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Ala Gly Ser Met Arg Ser 
    610                 615                 620                 


Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg Ala Ala Ser Ile Gly 
625                 630                 635                 640 


Asn Glu Leu His Val Ser Val Gln Asp Val Glu Lys Val Glu Lys Trp 
                645                 650                 655     


Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala Phe Arg Thr Ser Asn 
            660                 665                 670         


Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp Tyr Ala Arg Tyr Leu 
        675                 680                 685             


Lys Ser Tyr Val Asp Phe Ser Asn Ala Asp Met Pro Ser Glu Tyr Ser 
    690                 695                 700                 


Ala Leu Val Asp Phe Ser Asn Glu Glu Gln Ser Asp Leu Tyr Val Asp 
705                 710                 715                 720 


Pro Lys Asn Pro Lys Val Asn Arg Asn Ile Val His Ser Lys Leu Phe 
                725                 730                 735     


Ala Ala Asp His Ile Leu Arg Asp Ile Val Glu Pro Val Ser Lys Asp 
            740                 745                 750         


Asn Ile Glu Glu Phe Tyr Asp Gln Lys Ala Glu Ile Val Tyr Cys Lys 
        755                 760                 765             


Ile Lys Gly Lys Asp Ile Thr Ala Glu Glu Gln Lys Ala Val Leu Lys 
    770                 775                 780                 


Tyr Gln Lys Leu Lys Asn Arg Val Glu Leu Arg Asp Ile Val Glu Tyr 
785                 790                 795                 800 


Gly Glu Ile Ile Asn Glu Leu Leu Gly Gln Leu Ile Asn Trp Ser Phe 
                805                 810                 815     


Met Arg Glu Arg Asp Leu Leu Tyr Phe Gln Leu Gly Phe His Tyr Asn 
            820                 825                 830         


Cys Leu Arg Asn Asn Ser Glu Lys Lys Glu Ala Tyr Gln Lys Ile Glu 
        835                 840                 845             


Val Asn Gly Asp Ser Ile Lys Asp Ala Ile Leu Tyr Gln Ile Ile Gly 
    850                 855                 860                 


Met Tyr Val Asn Gly Val Ala Val Tyr Ala Pro Asp Glu Lys Gly Asp 
865                 870                 875                 880 


Ile Leu Lys Glu Gln Cys Thr Lys Gly Gly Ala Gly Gly Lys Ile Ser 
                885                 890                 895     


Ala Phe Asn Arg Tyr Ser Glu Tyr Leu Gly Leu Asp Lys Leu Thr Leu 
            900                 905                 910         


Tyr Asn Ala Gly Leu Glu Ile Phe Glu Val Val Ala Glu His Asp Asp 
        915                 920                 925             


Ile Ile Asn Leu Arg Asn Gly Ile Asp His Phe Lys Tyr Tyr Leu Gly 
    930                 935                 940                 


Asp Tyr Arg Ser Met Leu Ser Ile Tyr Ser Glu Val Phe Asp Arg Phe 
945                 950                 955                 960 


Phe Thr Tyr Asp Ile Lys Tyr Gln Lys Asn Val Leu Asn Leu Leu Gln 
                965                 970                 975     


Asn Ile Leu Leu Arg His Asn Val Ile Val Glu Pro Val Leu Glu Ser 
            980                 985                 990         


Gly Phe Lys Thr Ile Gly Lys Gln  Thr Thr Ser Gly Ala  Lys Leu Ser 
        995                 1000                 1005             


Ile Arg  Ser Ile Lys Ser Asp  Thr Phe Gln Tyr Lys  Val Lys Gly 
    1010                 1015                 1020             


Gly Ser  Leu Ile Thr Asp Ala  Lys Asp Glu Arg Tyr  Leu Lys Thr 
    1025                 1030                 1035             


Ile Arg  Lys Ile Leu Tyr Tyr  Val Glu Asn Glu Glu  Asp Asn Leu 
    1040                 1045                 1050             


Lys Lys  Ser Val Val Val Thr  Asn Ala Asp Lys Tyr  Glu Lys Asn 
    1055                 1060                 1065             


Lys Glu  Ser Asp Asp Gln Asn  Lys Gln Lys Glu Lys  Lys Asn Lys 
    1070                 1075                 1080             


Asp Asn  Lys Gly Lys Lys Asn  Glu Glu Thr Lys Ser  Asp Ala Gly 
    1085                 1090                 1095             


Lys Asn  Asn Asn Glu Arg Leu  Ser Tyr Asn Pro Phe  Ala Asn Leu 
    1100                 1105                 1110             


Asn Phe  Lys Leu Pro Asn 
    1115                 


<210>  716
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  716

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Thr Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  717
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  717

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Gly Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  718
<211>  1154
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  718

Met Gly Ser Gly Lys Tyr Arg Ile Thr Lys Ile Ala Arg Asn Trp Asp 
1               5                   10                  15      


Lys Asn Lys Glu Arg Ile Thr Leu Lys Arg Ile Val Ser Asp Gly Gln 
            20                  25                  30          


Val Lys Tyr Val Asn Glu Asn Asp Asn Val Asp Met Asp Ile Thr Glu 
        35                  40                  45              


Thr Tyr Tyr Lys Ile Leu Ser Asn Asn Glu Ala Lys Phe Leu Gly Ser 
    50                  55                  60                  


Met Glu Gln Phe Ile Phe Lys Val Asn Lys Met Lys Arg Asn Ile Lys 
65                  70                  75                  80  


Asn Asn Cys Val Ile Ile Lys Asp Tyr Thr Glu Glu Glu Tyr Asp Lys 
                85                  90                  95      


Phe Glu Glu Lys Asn Tyr Lys Ile Phe Lys Lys Leu Ile Ile Ala Glu 
            100                 105                 110         


Glu Gln Gly Lys Asn Val Lys Lys Lys Lys Ile Cys Arg Asn Phe Tyr 
        115                 120                 125             


Glu Asp Glu Arg Glu Ile Met Glu Lys Arg Leu Glu Glu Ala Lys Asn 
    130                 135                 140                 


Phe Asn Asn Ile Ile Phe Asn Ile Cys Asn Lys Ile Phe Lys Leu Glu 
145                 150                 155                 160 


Tyr Leu Asp Tyr Thr Asp Glu Lys Val Tyr Lys Ile Phe His Glu Glu 
                165                 170                 175     


Ile Lys Phe Glu Asp Ile Lys Asn Leu Lys Glu Ala Phe Lys Gln Gln 
            180                 185                 190         


Glu Lys Gly Leu Glu Thr Asp Lys Leu Leu Ala Ile Ser Phe Asn Lys 
        195                 200                 205             


Lys Arg Asn Asn Ile Leu Leu Glu Phe Ile Gln Gln Ile Val Lys Gln 
    210                 215                 220                 


Lys Phe Lys Asn Glu Lys Glu Leu Glu Asn Trp Phe Ser His Glu Gly 
225                 230                 235                 240 


Glu Lys Tyr Cys Lys Glu Ile Phe Lys Ile Tyr Ser Asn Met Ser Gln 
                245                 250                 255     


Lys Glu Lys Tyr Ser Lys Leu Leu Gly His Arg Asn Gln Gly Ile Ala 
            260                 265                 270         


Ser Ile Tyr Asp Glu Lys Lys Glu Thr Leu Gln Arg Arg Leu Lys Leu 
        275                 280                 285             


Gly Asn Tyr Ser Asp Tyr Asp Leu Arg Lys Tyr Tyr Gln Lys Asp Tyr 
    290                 295                 300                 


Lys Glu Glu Ala Ile Lys Glu Leu Lys Asp Lys Asn Lys Glu Glu Leu 
305                 310                 315                 320 


Glu Arg Glu Ile Glu Glu Leu Ile Lys Lys Asn Tyr Lys Ile Asp Lys 
                325                 330                 335     


Leu Cys Asp Glu Ile Ser Asn Leu Glu Phe Ser Phe Val Glu Ser Lys 
            340                 345                 350         


Lys Glu Asn Lys Asp Lys Met Ser Glu Ile Ile Val Lys Ile Lys Glu 
        355                 360                 365             


His Tyr Lys Lys Asn Val Asn Val Glu Glu Glu Leu Lys Asn Lys Glu 
    370                 375                 380                 


Lys Tyr Ile Leu Ser Leu Ile His Asn Tyr Val Lys Gly Arg Tyr Arg 
385                 390                 395                 400 


Lys Cys Leu Glu Leu Gln Gln Lys Glu Asn Val Asp Phe Glu Asn Leu 
                405                 410                 415     


Gly Lys Arg Ile Lys Asp Ile Phe Asp Ser Asn Glu Val Thr Lys Lys 
            420                 425                 430         


Leu Lys Lys Ser Ile Ile Asn Lys Val Asn Ser Tyr Lys Ile Phe Glu 
        435                 440                 445             


Met Lys Phe Gln Asn Pro Asn Ile Glu Ser Ser Asp Asp Leu Glu Ile 
    450                 455                 460                 


Leu Lys Ala Glu Glu Thr Phe Leu Asn Lys Leu Ser Thr Ala Val Ser 
465                 470                 475                 480 


Lys Val Gly Tyr Thr Leu Asn Ile Leu Leu Gly Val Ser Leu Glu Lys 
                485                 490                 495     


Asp Ile Leu Glu Asn Tyr Asn Met Val Gly Glu Leu Cys Asn Asn Asn 
            500                 505                 510         


Ser Thr Thr Glu Ile Tyr Lys Val Tyr Pro Glu Leu Glu Lys Asn Glu 
        515                 520                 525             


Lys Leu Leu Gln Gly Met Ile His Phe Ile Gln Gly Leu Arg Gln Gln 
    530                 535                 540                 


Ser Leu His Pro Lys Ile Leu Trp Asn Phe Glu Thr Lys Asn Leu Lys 
545                 550                 555                 560 


Ser Glu Lys Leu Glu Arg Leu Lys Glu Lys Lys Asn Ile Lys Met Arg 
                565                 570                 575     


Asp Cys Val Val His Glu Asp Asn Leu Asp Lys Lys Glu Lys Asn Glu 
            580                 585                 590         


Val Glu Ile Lys Lys Tyr Phe Glu Lys Ile Glu Glu Lys Leu Pro Asp 
        595                 600                 605             


Tyr Phe Ile Glu Lys Tyr Glu Ser Asn Asn Val Phe Asn Ile Tyr Arg 
    610                 615                 620                 


Asn Phe Val Asp Lys Ile Met Glu Val Val Lys Asn Phe Asn Phe Lys 
625                 630                 635                 640 


Glu Asn Asn Thr Ile Asp Tyr Leu Phe Pro Lys Phe His Lys Ile Tyr 
                645                 650                 655     


Lys Lys Met Ser Lys Leu Glu Asn Ile Met Cys Lys Ser Glu Asn Ile 
            660                 665                 670         


Asp Asp Arg Gln Asn Gly Ala Arg Lys Tyr Leu Leu Gln Thr Ile Tyr 
        675                 680                 685             


Tyr Tyr Tyr Phe Gln Tyr Glu Ile Glu Asn Asn Lys Asn Asn Ile Phe 
    690                 695                 700                 


Lys Tyr Tyr Arg Asn Ile Gln Arg Glu Gly Met Leu Asn Asn Arg Leu 
705                 710                 715                 720 


Ser Gln Met Asn Asn Glu Trp Ile Glu Phe Ile Val Val Gln Phe Ser 
                725                 730                 735     


Glu Phe Leu Thr Asn Lys Lys Leu Asn Trp Ile Leu Asp Asp Leu Ser 
            740                 745                 750         


Glu Tyr Lys Lys Lys Glu Lys Leu Asp Asn Ser Asp Lys Asp Lys Leu 
        755                 760                 765             


Arg Glu Met Leu Lys Leu Lys Met Asn Lys Lys Leu Ile Tyr Ser Asn 
    770                 775                 780                 


Asp Ser Tyr Val Phe Ile Ser Leu Ala Gln Phe Leu Asp Leu Lys Glu 
785                 790                 795                 800 


Ile Ser Asn Leu Ile His Asp Ile Lys Lys Phe Ile Gln Phe Arg Glu 
                805                 810                 815     


Lys Asn Val Ser Lys Tyr Lys Pro Glu Lys Asn Lys Leu Tyr Ile Glu 
            820                 825                 830         


Glu Leu Lys Lys Ile Leu Tyr Ile Leu Lys Val Met Leu Glu His Lys 
        835                 840                 845             


Glu Arg Val Ile Gln Lys His Tyr Leu Glu Ser Tyr Asp Glu Asn Ile 
    850                 855                 860                 


Ser Ile Met Tyr Gly Lys Asp Ile Glu Lys Lys Asp Ile Lys Asp Ile 
865                 870                 875                 880 


Glu Ile Lys Ile Lys Asn Lys Asn Trp Glu Val Ile Asn Gln Pro Leu 
                885                 890                 895     


Tyr Lys Ser Gly Asn Asp Glu Lys Ser Ser Trp Ile Val Leu Tyr Gly 
            900                 905                 910         


Ile Glu Gln Ala Lys Arg Asn Gly Thr Phe Lys Phe Phe Glu Gly Phe 
        915                 920                 925             


Phe Asn Leu Asn Asp Asp Ile Lys Leu Cys Lys Glu Asn Ile Glu Lys 
    930                 935                 940                 


Tyr Glu Lys Leu Tyr Asn Glu Arg Glu Glu Asn Gln Arg Lys Val Asp 
945                 950                 955                 960 


Glu Tyr Ile Ser Ser Glu Glu Asn Asn Asn Ile Asp Glu Ile Lys Glu 
                965                 970                 975     


Ile Asn Asn Asn Lys Gln Leu Phe Tyr Tyr Tyr Lys Asn Met Ile Tyr 
            980                 985                 990         


Gly Asp Gly Leu Lys Lys Gly Tyr  Asp Phe Ile Asn Asp  Ile Tyr Ser 
        995                 1000                 1005             


His Tyr  Leu Ser Trp Ala Tyr  Arg Ile Glu Arg Asp  Cys Lys Ile 
    1010                 1015                 1020             


Tyr Lys  Ile Lys Lys Tyr Glu  Asn Lys Lys Asn Ser  Asn Glu Tyr 
    1025                 1030                 1035             


Lys Phe  Lys Glu Tyr Lys Ser  Ile Gln Asn Phe Arg  Asn Lys Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Phe Gln  Lys Thr Asp Lys Ser  Leu Leu Asp 
    1055                 1060                 1065             


Leu Leu  Asn Asp Phe Tyr Ser  Ile Phe Asp Tyr Asn  Leu Lys Tyr 
    1070                 1075                 1080             


Gln Arg  Asp Val Gln Lys Val  Ile Asn Asn Ile Phe  Glu Lys Tyr 
    1085                 1090                 1095             


Gln Val  Val Arg Glu Asp Gly  Gly Pro Val Ile Phe  Tyr Cys Lys 
    1100                 1105                 1110             


Val Asp  Lys Lys Leu Lys Leu  Ser Glu Asn Leu Val  Pro Lys Lys 
    1115                 1120                 1125             


His Ser  Lys Tyr Gln Glu Ile  Lys Leu Ile His Glu  Arg Tyr Val 
    1130                 1135                 1140             


Val Phe  Phe Lys Lys Leu Phe  Glu Tyr Lys Lys 
    1145                 1150                 


<210>  719
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  719

Met Gly Asn Leu Phe Gly Tyr Lys Arg Trp Tyr Glu Val Arg Asp Lys 
1               5                   10                  15      


Glu Asp Tyr Lys Ile Lys Arg Lys Val Lys Val Lys Arg Asn Tyr Asp 
            20                  25                  30          


Gly Asn Lys Tyr Ile Leu Asn Ile Asn Glu Asn Asn Asn Lys Glu Lys 
        35                  40                  45              


Ile Asp Asp Asn Lys Phe Ile Arg Glu Phe Val Asn Tyr Lys Lys Asn 
    50                  55                  60                  


Asp Asn Val Leu Lys Glu Phe Lys Lys Lys Phe His Gly Gly Asn Ile 
65                  70                  75                  80  


Leu Phe Lys Leu Lys Gly Asn Lys Arg Ser Ile Glu Asp Ser Asn Asp 
                85                  90                  95      


Phe Leu Lys Thr Glu Glu Val Val Leu Asp Lys Glu Ile Tyr Gly Gln 
            100                 105                 110         


Ser Glu Lys Leu Arg Asn Glu Lys Gly Ile Thr Lys Lys Asp Ile Leu 
        115                 120                 125             


Lys Glu Ile Asn Lys Gln Lys Ile Asp Asn Ser Val Lys Lys Ile Ser 
    130                 135                 140                 


Met Asn Thr Asn Ser Gly Lys Thr Ile Val Ile Asn Phe Ser Asp Lys 
145                 150                 155                 160 


Leu Lys Lys Asp Lys Asp Asp Tyr Gln Ile Thr Leu Asn Ile Ile Ser 
                165                 170                 175     


Glu Asp Glu Leu Glu Arg Lys Arg Lys Ile Tyr Asp Ile Phe Lys Met 
            180                 185                 190         


Ile Asn Met Asp Leu Tyr Gln Ile Ile Lys Glu Ile Ile Glu Asn Glu 
        195                 200                 205             


Val Gln Lys Val Phe Lys Asn Arg Tyr Tyr Glu Glu His Leu Arg Glu 
    210                 215                 220                 


Lys Leu Leu Lys Asp Asp Lys Ile Asp Val Ile Leu Thr Asn Phe Met 
225                 230                 235                 240 


Lys Ile Arg Glu Lys Ile Glu Ser Asn Pro Glu Ile Met Gly Phe Val 
                245                 250                 255     


Lys Phe Tyr Leu Asn Val Gly Gly Asp Lys Lys Lys Ser Glu Asn Lys 
            260                 265                 270         


Lys Ile Phe Val Glu Lys Ile Leu Asn Ile Asn Val Asp Leu Thr Val 
        275                 280                 285             


Glu Asp Ile Val Asp Phe Ile Val Lys Glu Leu Lys Phe Tyr Gly Ile 
    290                 295                 300                 


Ile Lys Arg Ile Glu Lys Leu Gln Glu Lys Lys Ala Asp Arg Thr Asp 
305                 310                 315                 320 


Glu Asp Ile Lys Lys Thr Tyr Ile Asn Thr Tyr Val Ser Leu Asp Lys 
                325                 330                 335     


His Glu Lys Phe Lys Lys Tyr Asn Arg Asn Lys Lys Asp Thr Ile Val 
            340                 345                 350         


Lys Ser Phe Ile Lys Asp Ile Lys Asp Asn Thr Met Lys Gln Lys Ile 
        355                 360                 365             


Asn Gln Ile Leu Arg Lys Phe Lys Ile Lys Glu Leu Ile Glu Lys Leu 
    370                 375                 380                 


Arg Ile Glu Asn Lys Asn Phe Asp Thr Glu Ile Phe Arg Ile Phe Lys 
385                 390                 395                 400 


Asp His Tyr Gln Glu Met Phe Ser Ser Glu Lys Phe Glu Glu Lys Ser 
                405                 410                 415     


Asp Glu Glu Lys Glu Leu Tyr Lys Ile Ile Tyr Arg Tyr Leu Lys Gly 
            420                 425                 430         


Arg Ile Glu Lys Ile Leu Ile Asn Glu Gln Lys Val Arg Leu Lys Lys 
        435                 440                 445             


Met Glu Lys Ile Glu Val Glu Lys Ile Leu Asn Glu Ser Thr Leu Ser 
    450                 455                 460                 


Glu Lys Ile Leu Lys Arg Val Lys Gln Tyr Thr Leu Glu His Ile Met 
465                 470                 475                 480 


Tyr Leu Gly Lys Leu Val His Asn Asn Ile Asp Met Thr Thr Val Asn 
                485                 490                 495     


Thr Asn Asp Phe Ser Met Leu His Ala Lys Glu Glu Leu Asp Leu Glu 
            500                 505                 510         


Leu Ile Thr Phe Phe Ala Ser Thr Asn Met Glu Leu Asn Lys Ile Phe 
        515                 520                 525             


Asn Gly Lys Glu Lys Val Thr Asp Phe Phe Gly Phe Asn Leu Thr Glu 
    530                 535                 540                 


Gln Lys Ile Thr Leu Lys Glu Lys Val Pro Ser Phe Lys Leu Asn Ile 
545                 550                 555                 560 


Leu Lys Lys Leu Asn Phe Ile Asn Asn Glu Asn Asn Ile Asp Glu Lys 
                565                 570                 575     


Leu Ser His Phe Tyr Ser Phe Gln Lys Glu Gly Tyr Leu Leu Arg Asn 
            580                 585                 590         


Lys Ile Leu His Asn Ser Tyr Arg Asn Ile Gln Glu Thr Lys Asn Leu 
        595                 600                 605             


Glu Glu Asp Tyr Lys Asn Val Thr Asn Leu Ile Asp Glu Leu Lys Val 
    610                 615                 620                 


Ser Asp Glu Glu Ile Ser Lys Ser Leu Asn Leu Asp Val Ile Phe Glu 
625                 630                 635                 640 


Gly Lys Lys Asn Ile Ile Ile Glu Ile Asn Lys Leu Lys Thr Gly Lys 
                645                 650                 655     


Tyr Lys Asp Lys Lys Tyr Leu Pro Ser Phe Ser Lys Ile Val Pro Glu 
            660                 665                 670         


Ile Thr Arg Lys Phe Arg Glu Ile Asn Lys Asp Lys Ser Phe Asp Ile 
        675                 680                 685             


Glu Ser Glu Lys Ile Ile Leu Asn Ala Val Lys Tyr Val Asn Lys Ile 
    690                 695                 700                 


Leu Tyr Glu Lys Ile Thr Ser Asn Glu Glu Asn Gln Phe Ile Lys Thr 
705                 710                 715                 720 


Leu Pro Asp Lys Leu Val Lys Lys Asn Asn Asn Lys Glu Asn Lys Asn 
                725                 730                 735     


Ser Leu Ser Ile Glu Glu Tyr Tyr Lys Asn Ala Gln Ile Ser Ser Ser 
            740                 745                 750         


Lys Gly Asp Lys Lys Ala Ile Lys Lys Tyr Gln Asn Lys Val Ile Asn 
        755                 760                 765             


Ala Tyr Leu Glu Tyr Leu Glu Asn Thr Phe Val Glu Val Ile Asp Phe 
    770                 775                 780                 


Ser Asn Phe Asn Leu Asn Phe Asp Glu Ile Lys Thr Lys Ile Glu Glu 
785                 790                 795                 800 


Arg Lys Asp Ser Lys Asn Lys Ile Val Ile Asp Ser Ile Ser Thr Asn 
                805                 810                 815     


Ile Asn Ile Thr Asn Asp Thr Glu Tyr Ile Ile Ser Ile Phe Ala Leu 
            820                 825                 830         


Leu Asn Asn Asn Thr Tyr Ile Asn Lys Ile Arg Asn Arg Phe Phe Ala 
        835                 840                 845             


Thr Ser Val Trp Leu Glu Lys Gln Asn Ser Thr Lys Glu Tyr Asp Tyr 
    850                 855                 860                 


Glu Asn Ile Ile Ser Ile Leu Asp Glu Ile Ile Gln Leu Asn Thr Leu 
865                 870                 875                 880 


Arg Asn Glu Cys Ile Ile Glu Asn Trp Asn Ser Asn Leu Lys Glu Phe 
                885                 890                 895     


Ile Gln Lys Met Leu Asp Val Glu Lys Glu Ile Gly Asn Phe Glu Ile 
            900                 905                 910         


Lys Thr Lys Lys Glu Ile Phe Glu Ile His Tyr Glu Glu Ile Lys Lys 
        915                 920                 925             


Asp Met Ile Val Lys Ile Asn Asp Asn Lys Ile Gln Lys Ile Leu Asn 
    930                 935                 940                 


Lys Tyr Leu Lys Glu Ile Thr Gly Phe Ser Ser Asn Asn Glu Tyr Met 
945                 950                 955                 960 


Phe Lys Asn Leu Gly Lys Leu Thr Leu Glu Glu Arg Asp Phe Ile Leu 
                965                 970                 975     


Pro Asn Lys Lys Leu Ile Glu Lys Asn Ile Asp Glu Ile Ile Gly Glu 
            980                 985                 990         


Lys Leu Asp Ala Ile Lys Glu Lys  Ile Leu Leu Arg Lys  Val Phe Ser 
        995                 1000                 1005             


Ser Lys  Phe Leu Glu Lys Tyr  Lys Lys Glu Ile Asp  Asn Leu Ile 
    1010                 1015                 1020             


Glu Asp  Thr Glu Ser Glu Asn  Lys Asn Lys Phe Glu  Lys Ile Tyr 
    1025                 1030                 1035             


Tyr Pro  Glu Glu His Lys Asn  Glu Leu Tyr Ile Tyr  Lys Lys Asn 
    1040                 1045                 1050             


Leu Phe  Leu Asn Ile Gly Asn  Pro Asn Phe Asp Lys  Ile Tyr Glu 
    1055                 1060                 1065             


Leu Ile  Ser Lys Asp Ile Lys  Asn Ala Asn Thr Glu  Ile Leu Phe 
    1070                 1075                 1080             


Asn Asp  Asp Ile Arg Lys Asn  Lys Ile Ala Glu Ile  Asp Val Ile 
    1085                 1090                 1095             


Leu Lys  Asn Leu Asn Asp Lys  Leu Asn Gly Tyr Ser  Asn Asp Tyr 
    1100                 1105                 1110             


Lys Glu  Lys Tyr Val Asn Lys  Leu Lys Glu Asn Asp  Asp Phe Phe 
    1115                 1120                 1125             


Ala Lys  Asn Ile Gln Asn Lys  Asn Tyr Lys Ser Phe  Glu Lys Phe 
    1130                 1135                 1140             


Glu Lys  Asp Tyr Asn Lys Val  Ser Glu Tyr Lys Lys  Ile Arg Asp 
    1145                 1150                 1155             


Leu Val  Glu Phe Asn Tyr Leu  Asn Lys Ile Glu Ser  Tyr Leu Ile 
    1160                 1165                 1170             


Asp Ile  Asn Trp Lys Leu Ala  Ile Gln Met Ala Arg  Phe Glu Arg 
    1175                 1180                 1185             


Asp Met  His Tyr Ile Val Asn  Gly Leu Lys Glu Leu  Asn Phe Ile 
    1190                 1195                 1200             


Asn Leu  Asn Ser Tyr Asn Ala  Gly Ile Ser Arg Ala  Tyr Pro Lys 
    1205                 1210                 1215             


Tyr Asn  Asp Ser Asp Ser Asn  Lys Asn Cys Lys Lys  Phe Tyr Glu 
    1220                 1225                 1230             


Thr Thr  Ala Tyr Tyr Lys Phe  Phe Asp Asp Lys Ser  Tyr Arg Glu 
    1235                 1240                 1245             


Phe Glu  Asp Ile Cys Tyr Glu  Phe Gly Ile Asp Leu  Arg Lys Asn 
    1250                 1255                 1260             


Ser Asn  Ile Gln Ala Lys Gly  Glu Arg Asn Ile Arg  Asn Tyr Ile 
    1265                 1270                 1275             


Ser His  Phe Tyr Ile Val Arg  Asn Pro Phe Val Asp  Tyr Ser Ile 
    1280                 1285                 1290             


Ala Glu  Gln Ile Asp Arg Val  Ser Asn Leu Leu Ser  Tyr Ser Thr 
    1295                 1300                 1305             


Arg Tyr  Asn Asn Ser Thr Tyr  Ala Ser Val Phe Glu  Val Phe Lys 
    1310                 1315                 1320             


Lys Asp  Val Asn Leu Asp Tyr  Asp Lys Leu Lys Lys  Lys Phe Lys 
    1325                 1330                 1335             


Leu Ile  Gly Asn Asn Asp Ile  Leu Glu Arg Leu Met  Lys Pro Lys 
    1340                 1345                 1350             


Lys Val  Ser Val Leu Glu Val  Glu Ser Tyr Asn Ser  Asp Tyr Ile 
    1355                 1360                 1365             


Lys Asn  Leu Ile Ile Glu Leu  Leu Thr Lys Val Glu  Asn Lys Asp 
    1370                 1375                 1380             


Glu Ile  Ser Ser 
    1385         


<210>  720
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  720

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Val Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Phe Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Tyr Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Lys Ile Leu Lys Tyr Thr Glu Ser Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Ala Phe Ser Asp Gln Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Tyr Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asp Lys Ile Gly Lys Phe Leu Asn Phe Asn Gly Asn 
            820                 825                 830         


Lys Val Lys Asp Asn Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Lys Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Glu Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Lys 
        915                 920                 925             


Lys Tyr Glu Lys Ala Ile Arg Asn Ile Gln Gln Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Ser Leu Leu Leu 
945                 950                 955                 960 


Arg Ile Leu His Arg Leu Ile Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Asn Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Ser Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asp  Thr Glu Lys Ile Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Glu Leu  Lys Lys Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  Asn Ala Lys Val Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Thr Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Glu Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Lys  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  721
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  721

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  722
<211>  1257
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  722

Met Arg Gly Gly His Met Lys Ile Thr Lys Ile Asp Gly Ile Ser His 
1               5                   10                  15      


Tyr Lys Glu Lys Glu Lys Gly Val Leu Lys Ala Lys Asp Val Leu Asn 
            20                  25                  30          


Glu Glu Ile Lys Glu Ile Val Lys Lys Arg Tyr Asp Ala Thr Ile Glu 
        35                  40                  45              


Ser Lys Ile Tyr Lys Glu Phe Ile Lys Leu Arg Lys Asn Arg Ile Glu 
    50                  55                  60                  


Gln Asn Asn Glu Lys Ser Val Leu Glu Leu Ile Lys Ser Asn Ile Asp 
65                  70                  75                  80  


Lys Asn Glu Lys Glu Ile Lys Thr Leu Leu Trp Asn Lys Phe Lys Ile 
                85                  90                  95      


Lys Glu Lys Asn Lys Lys Tyr Asp Lys Tyr Ile Leu Asp Glu Ile Lys 
            100                 105                 110         


Leu Asp Asn Asp Ile Lys Ile Tyr Glu Ser Ala Glu Ser Leu Tyr Phe 
        115                 120                 125             


Phe Ile Lys Glu Ala Tyr Leu Gly Gln Asn Asn Lys Lys Trp Asn Ile 
    130                 135                 140                 


Ser Lys Ile Asp Leu Glu Lys Ile Met Glu Lys Asp Asn Asn Leu Ile 
145                 150                 155                 160 


Met Leu Gly Tyr Lys Leu Lys Lys Asn Ile Lys Glu Asp Glu Tyr Pro 
                165                 170                 175     


Tyr Leu Tyr Lys Asn Lys Asn Lys Gln Lys Ser Thr Pro Leu Tyr Thr 
            180                 185                 190         


Leu Leu Lys Lys Leu Ile Glu Lys Asn Lys Asn Ser Asn Gln Asn Ile 
        195                 200                 205             


Arg Glu Ser Glu Glu Tyr Glu Lys Ile Gln Lys Asp Phe Lys Glu Tyr 
    210                 215                 220                 


Lys Asn Ile Lys Ile Asn Leu Leu Val Lys Ser Ile Leu Asn Asn Lys 
225                 230                 235                 240 


Val Asn Ile Lys Tyr Asn Thr Ser Asn Asn Asn Ile Glu Glu Ser Asn 
                245                 250                 255     


Ser Lys Arg Glu Lys Glu Ile Ile Glu Phe Phe Lys Lys Met Ile Glu 
            260                 265                 270         


Glu Lys Asn Lys Ser Ile Leu Lys Asp Lys Leu Lys Leu Phe Arg Leu 
        275                 280                 285             


Glu Val Phe Phe Asp Glu Glu Phe Leu Glu Glu Ile Lys Lys Leu Leu 
    290                 295                 300                 


Asp Asn Asp Asn Leu Asp Lys Ser Asp Asn Lys Lys Ile Ala Glu Leu 
305                 310                 315                 320 


Arg Gly Lys Ile Phe Ser Arg Ile Arg Glu Lys Ile Lys Glu Asp Lys 
                325                 330                 335     


Asn Arg Asp Ile Leu Lys Asn Ile Tyr Phe Leu Glu Leu Lys Lys Tyr 
            340                 345                 350         


Ile Glu Asn Asn Leu Ser His Lys Lys Glu Asn Asn Lys Lys Asn Asn 
        355                 360                 365             


Asn Ile Gly Glu Glu Lys Ser Lys Glu Leu Tyr Leu Lys Phe Leu Lys 
    370                 375                 380                 


Lys Val Leu Phe Ile Asp Asp Asn Asn Arg Ile Ser Ile Glu Lys Leu 
385                 390                 395                 400 


Lys Ser Arg Ile Asp Asp Asn Phe Lys Asn Leu Leu Ile Gln His Val 
                405                 410                 415     


Ile Glu Tyr Gly Lys Ile Lys Tyr Tyr Val Glu Asn Asp Asp Tyr Ile 
            420                 425                 430         


Lys Asn Ile Val Lys Asn Gly Glu Leu Lys Leu Glu Thr Glu Asn Leu 
        435                 440                 445             


Glu Tyr Ile Arg Val Arg Glu Thr Leu Ile Arg Lys Met Ala Val Leu 
    450                 455                 460                 


Val Ser Phe Ala Ala Asn Ser Phe Tyr Asn Leu Phe Glu Asn Ile Thr 
465                 470                 475                 480 


Ser Asp Ile Leu Thr Ala Asn Ile Asn Leu Asp Ser Asp Val Ile Lys 
                485                 490                 495     


Ile Gly Asn Asn Arg Leu Lys Glu Lys Phe Leu Asn Tyr Phe Phe Tyr 
            500                 505                 510         


Ser Glu Glu Ile Ser Asp Lys Glu Asp Phe Leu Lys Ala Leu Lys Asp 
        515                 520                 525             


Ser Ile Tyr Asn Val Arg Asn Gly Val Asn His Phe Asp Lys Met Ile 
    530                 535                 540                 


Leu Gly Lys Tyr Asn Asn Arg Leu Asp Leu Lys Asp Ser Asn Thr Ile 
545                 550                 555                 560 


Lys Asp Tyr Phe Asn Phe Lys Lys Lys Glu Ile Lys Gln Asp Leu Lys 
                565                 570                 575     


Asp Arg Phe Ile Ser Asn Asn Leu Gln Tyr Tyr Tyr Thr Glu Asn Glu 
            580                 585                 590         


Ile Lys Lys Tyr Phe Glu Lys Tyr Lys Phe Glu Ile Leu Lys Thr Lys 
        595                 600                 605             


Ala Ser Phe Ala Pro Asn Phe Lys Arg Ile Leu Arg Lys Gly Glu Asn 
    610                 615                 620                 


Leu Ser Ile Ser Glu Ile Ser Asp Ile Tyr Asp Phe Phe Lys Arg Tyr 
625                 630                 635                 640 


Ser Glu Asn Ser Asp Lys Ser Ser Glu Tyr Asn Glu Phe Thr Lys Thr 
                645                 650                 655     


Arg Asn Phe Leu Leu Lys Glu Leu Tyr Tyr Asn Asn Phe Tyr Arg Glu 
            660                 665                 670         


Phe Leu Ser Asp Arg Thr Lys Phe Glu Glu Ala Val Lys Lys Val Lys 
        675                 680                 685             


Asn Asn Lys Lys Asn Arg Ile Ile Asp Asn Arg Lys Ser Ala Gly Lys 
    690                 695                 700                 


Ser Tyr Asp Val Ile Glu Asp Tyr Asn Ser Ser Asp Asp Val Leu Glu 
705                 710                 715                 720 


Tyr Ile Ser Arg Ile His Lys Ser Glu Met Glu Arg Ile Glu Val Asn 
                725                 730                 735     


Thr Glu Lys Asn Arg Lys Asp Thr Ser Lys Tyr Ile Arg Asp Phe Ile 
            740                 745                 750         


Glu Glu Val Phe Leu Glu Gly Phe Ile Lys Tyr Leu Asp Asn Asn Asn 
        755                 760                 765             


Phe Asn Phe Leu Lys Asn Arg Asn Lys Ala Asp Lys Glu Arg Lys Glu 
    770                 775                 780                 


Ile Val Arg Asn Leu Asn Ile Lys Ile Glu Gly Leu Asp Ile Leu Asn 
785                 790                 795                 800 


Gln Asn Asp Ser Glu Ile Leu Asn Leu Tyr Leu Phe Phe Asn Met Ile 
                805                 810                 815     


Asp Asn Lys Arg Ile Ser Glu Phe Arg Asn Glu Met Ile Lys Tyr Lys 
            820                 825                 830         


Gln Phe Leu Thr Lys Arg Gln Asn Ile Lys Ser Lys Phe Leu Glu Ile 
        835                 840                 845             


Asp Ile Glu Lys Ile Glu Ala Ile Ile Glu Phe Val Ile Ile Thr Arg 
    850                 855                 860                 


Gly Lys Leu Glu Ile Leu Glu Gly Glu Thr Lys Glu Gln Lys Lys Asp 
865                 870                 875                 880 


Asn Met Asn Ala Leu Phe Asn Lys Phe Tyr Ser Ser Glu Ser Glu Tyr 
                885                 890                 895     


Asp Glu Ser Leu Lys Lys Phe Ile Glu Glu Thr Val Leu Asn Asp Lys 
            900                 905                 910         


Lys Asn Thr Pro Phe Tyr Ser Thr Asp Gly Lys Thr Pro Ile Val His 
        915                 920                 925             


Ser Asn Leu Glu Lys Met Arg Lys Tyr Gly Thr Glu Asn Phe Leu Ser 
    930                 935                 940                 


Lys Val Leu Lys Asp Glu Lys Tyr Thr Leu Asp Asn Met Lys Ile Lys 
945                 950                 955                 960 


Glu Lys Phe Glu Thr Lys Val Asn Asp Lys Phe Lys Glu Gln Lys Ile 
                965                 970                 975     


Leu Glu Lys Val Asp Lys Ile Lys Gly Asn Glu Lys His Lys Lys Leu 
            980                 985                 990         


Ile Glu Tyr Tyr Asn Asp Cys Arg  Cys Tyr Leu His Gly  Glu Trp Ile 
        995                 1000                 1005             


Glu Asn  Lys Lys Asn Lys Glu  Glu Phe Glu Tyr Lys  Glu Ile Tyr 
    1010                 1015                 1020             


Glu Lys  Ile Ile Glu Glu Ile  Arg Lys Tyr Asn Tyr  Leu Glu Asn 
    1025                 1030                 1035             


Lys Glu  Lys Leu Gln Asn Val  Tyr Leu Leu His Glu  Ile Thr Ser 
    1040                 1045                 1050             


Asp Leu  Met Ala Arg Asn Val  Ala Phe Ile Asn Lys  Trp Glu Arg 
    1055                 1060                 1065             


Asp Phe  Lys Phe Leu Ser Ile  Ala Ile Lys Glu Asn  Leu Lys Asp 
    1070                 1075                 1080             


Ser Asn  Asp Ile Gln Lys Ile  Glu Glu Phe Leu Asn  Pro Ser Leu 
    1085                 1090                 1095             


Asp Thr  Thr Ser Asp Glu Glu  His Phe Asn Val Lys  Asn Tyr Ala 
    1100                 1105                 1110             


Ser Lys  Leu Lys Asn Ile Gln  Gly Leu His Asn Asn  Ile Ile Ser 
    1115                 1120                 1125             


Leu Ile  Phe Ile Lys Asn Leu  Asp Gly Trp Asn Asn  Lys Ile Asp 
    1130                 1135                 1140             


Asn Phe  Lys Trp Leu Gly Phe  Arg Asn Tyr Ile Ser  His Phe Asn 
    1145                 1150                 1155             


His Ile  Asn Gly Glu Asn Ser  Lys Glu Ser Phe Ile  Asn Gln Leu 
    1160                 1165                 1170             


Asn Arg  Leu Val Leu Leu Phe  Ser Tyr Asp Lys Lys  Val Gln Asn 
    1175                 1180                 1185             


His Ile  Thr Lys Ser Ile Lys  Thr Ile Leu Glu Lys  Tyr Asn Ile 
    1190                 1195                 1200             


Asp Ile  Glu Phe Lys Ile Ser  Asp Asp Ser Lys Asn  Phe Phe Glu 
    1205                 1210                 1215             


Tyr Gln  Ile Ser Asn Ile Asn  Ser Lys Lys Gly Lys  Met Leu Gly 
    1220                 1225                 1230             


Lys Glu  Asn Tyr Phe Glu Leu  Leu Asp Lys Glu Phe  Val Gln Asn 
    1235                 1240                 1245             


Val Lys  Lys Met Leu Glu Tyr  Glu Asp 
    1250                 1255         


<210>  723
<211>  1194
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  723

Met Lys Val Thr Lys Ile Asp Gly Leu Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ile Glu Asp Ala Ser Gln Lys Asn Glu Thr 
            20                  25                  30          


Leu Glu Arg Leu Glu Asn Leu Lys Gly Ile Lys Leu Gly Asn Tyr Ile 
        35                  40                  45              


Lys Asn Thr Asp Lys Thr Lys Asn Lys Asp Asn Lys Lys Arg Arg Lys 
    50                  55                  60                  


Gly Leu Lys Glu Tyr Phe Ser Glu Ile Thr Leu Arg Lys Glu Asn Glu 
65                  70                  75                  80  


Lys Tyr Val Leu Leu Lys Gly Lys Lys Leu Lys Lys Ile Asn Asn Asp 
                85                  90                  95      


Ile Lys Asp Thr Asp Ile Lys Ala Lys Asp Lys Lys Glu Glu Val Phe 
            100                 105                 110         


Asp Ile Leu Lys Glu Ile Leu Lys Leu Asn Leu Leu Ala Asn Asp Ala 
        115                 120                 125             


Glu Glu Lys Ile Gln Phe Asp Ser Ile Lys Leu Lys Asn Val Phe Gly 
    130                 135                 140                 


Lys Asp Phe Val Lys Lys Glu Leu Gln Ile Lys Ser Ile Glu Glu Ser 
145                 150                 155                 160 


Leu Glu Lys Asn Lys Ala Asp Tyr Arg Lys Glu Phe Ile Glu Thr Glu 
                165                 170                 175     


Asn His Lys Tyr Gly Asn Val Lys Gly Lys Asn Lys Arg Ser His Ile 
            180                 185                 190         


Tyr Glu Tyr Tyr Lys Lys Ser Glu Asn His Lys Lys Phe Glu Asp Asn 
        195                 200                 205             


Ile Arg Glu Ala Phe Glu Lys Leu Tyr Thr Glu Glu Asn Ile Lys Glu 
    210                 215                 220                 


Leu Tyr Ser Lys Ile Glu Gln Val Leu Lys Lys Thr His Leu Lys Ser 
225                 230                 235                 240 


Ile Val Trp Glu Phe Tyr Lys Asn Glu Ile Ile Gly Glu Ser Glu Phe 
                245                 250                 255     


Ser Lys Lys Asn Gly Asp Gly Ile Ser Ile Leu Tyr Asn Gln Ile Lys 
            260                 265                 270         


Asp Ser Ile Lys Lys Glu Glu Asn Phe Ile Glu Phe Ile Glu Asn Ile 
        275                 280                 285             


Gly Asn Leu Glu Leu Lys Asp Leu Thr Lys Ser Gln Ile Phe Tyr Lys 
    290                 295                 300                 


Tyr Phe Leu Glu Asn Glu Glu Leu Asn Asp Glu Asn Ile Lys Phe Val 
305                 310                 315                 320 


Phe Cys Tyr Phe Val Glu Ile Glu Val Ser Asp Leu Leu Lys Gly Asn 
                325                 330                 335     


Val Tyr Lys Ala Ser Lys Ile Tyr Glu Asn Lys Ile Lys Asn Ile Phe 
            340                 345                 350         


Glu Tyr Gly Lys Leu Lys Lys Leu Ile Val Tyr Lys Leu Glu Asn Lys 
        355                 360                 365             


Leu Asn Asn Tyr Val Arg Asn Cys Gly Lys Tyr Asn Tyr His Met Glu 
    370                 375                 380                 


Asn Gly Asp Ile Ala Thr Ser Asp Ile Asn Met Arg Asn Arg Gln Thr 
385                 390                 395                 400 


Glu Ala Phe Leu Arg Ser Met Ile Gly Val Ser Ser Phe Gly Tyr Phe 
                405                 410                 415     


Ser Leu Arg Asn Ile Leu Gly Val Asn Asp Asp Asp Phe Tyr Glu Ile 
            420                 425                 430         


Glu Glu Asp Leu Thr Glu Glu Glu Arg Lys Asn Glu Ser Asn Ala Leu 
        435                 440                 445             


Lys Lys Ala Lys Glu Asp Ile Thr Ser Lys Ser Ile Phe Glu Lys Val 
    450                 455                 460                 


Val Asp Lys Ser Phe Glu Lys Lys Gly Ile Tyr Ser Ile Lys Glu Asn 
465                 470                 475                 480 


Leu Lys Met Phe Tyr Gly Asp Ser Phe Asp Lys Ala Asn Glu Asp Glu 
                485                 490                 495     


Leu Lys Gln Phe Phe Val Asn Met Leu Asn Ala Ile Thr Ser Ile Arg 
            500                 505                 510         


His Arg Val Val His Tyr Asn Met Asn Thr Asn Ser Glu Asn Ile Phe 
        515                 520                 525             


Asn Phe Ser Asp Ile Glu Val Ser Arg Leu Leu Lys Asn Ile Phe Glu 
    530                 535                 540                 


Lys Glu Thr Asp Lys Arg Glu Leu Lys Leu Lys Ile Phe Arg Gln Leu 
545                 550                 555                 560 


Asn Ser Ala Gly Val Phe Asp Tyr Trp Glu Ser Trp Lys Ile Lys Lys 
                565                 570                 575     


Tyr Leu Glu Asn Ile Glu Phe Lys Phe Val Asn Lys Asn Ile Pro Phe 
            580                 585                 590         


Val Pro Ser Phe Thr Lys Leu Tyr Asn Arg Ile Asp Asn Leu Lys Gly 
        595                 600                 605             


Asn Asn Ala Leu Lys Leu Gly Asn Tyr Ile Thr Ile Pro Lys Arg Lys 
    610                 615                 620                 


Glu Ala Arg Asp Ser Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly 
625                 630                 635                 640 


Glu Phe Val Glu Lys Phe Val Asn Asn Asn Asp Asn Phe Glu Lys Ile 
                645                 650                 655     


Phe Arg Glu Ile Ile Glu Ile Asn Lys Asn Ala Gly Thr Asn Thr Lys 
            660                 665                 670         


Thr Lys Phe Tyr Lys Leu Glu Lys Phe Glu Thr Leu Lys Ala Asn Thr 
        675                 680                 685             


Pro Thr Glu Tyr Leu Glu Lys Leu Gln Ser Leu His Gln Ile Asn Tyr 
    690                 695                 700                 


Asp Arg Glu Lys Ile Glu Glu Ala Lys Asp Ile Tyr Val Asp Phe Val 
705                 710                 715                 720 


Gln Lys Ile Phe Leu Lys Gly Phe Ile Asn Tyr Leu Gln Lys Ser Asn 
                725                 730                 735     


Ser Leu Lys Pro Leu Asn Leu Leu Asn Leu Lys Lys Asp Glu Val Ile 
            740                 745                 750         


Asn Ser Glu Lys Ser Ser Tyr Asp Glu Lys Leu Lys Gln Trp Glu Asn 
        755                 760                 765             


Asn Gly Ser Lys Leu Ser Glu Met Pro Lys Glu Ile Tyr Lys Tyr Ile 
    770                 775                 780                 


Lys Glu Ile Asn Ile Asn Lys Ile Asn Tyr Ser Asn Arg Met Ser Ile 
785                 790                 795                 800 


Phe Tyr Leu Leu Leu Lys Leu Ile Asp His Arg Glu Leu Thr Asn Leu 
                805                 810                 815     


Arg Gly Asn Leu Glu Lys Tyr Glu Ser Met Asn Lys Asn Lys Ile Tyr 
            820                 825                 830         


Ser Glu Glu Leu Asn Ile Val Asn Leu Val Ser Leu Asp Asn Asn Lys 
        835                 840                 845             


Val Arg Thr Asn Phe Ser Val Glu Ala Glu Asp Ile Gly Lys Phe Leu 
    850                 855                 860                 


Lys Thr Glu Thr Ser Ile Lys Asn Asn Lys Gln Leu Asn Asn Phe Ser 
865                 870                 875                 880 


Glu Ile Phe Ala Asp Gly Glu Asn Val Ile Lys His Arg Ser Phe Tyr 
                885                 890                 895     


Asn Ile Lys Lys Tyr Gly Ile Leu Asp Leu Leu Glu Lys Ile Val Thr 
            900                 905                 910         


Lys Ala Asp Leu Lys Ile Thr Lys Glu Glu Ile Lys Lys Tyr Lys Asn 
        915                 920                 925             


Leu Gln Lys Glu Leu Glu Lys Asn Asp Phe Tyr Lys Ile Gln Glu Asn 
    930                 935                 940                 


Ile His Arg Lys Tyr Asn Gln Lys Pro Asn Leu Ile Ser Arg Thr Glu 
945                 950                 955                 960 


Asn Lys Lys Asp Phe Asn Asp Tyr Lys Lys Ala Ile Glu Asn Ile Gln 
                965                 970                 975     


Asn Tyr Thr Gln Leu Lys Asn Lys Ile Glu Phe Asn Asp Leu Asn Leu 
            980                 985                 990         


Leu Gln Ser Leu Leu Phe Arg Ile  Leu His Arg Leu Ala  Gly Tyr Thr 
        995                 1000                 1005             


Ser Leu  Trp Glu Arg Asp Leu  Gln Phe Lys Leu Lys  Gly Glu Phe 
    1010                 1015                 1020             


Pro Glu  Asp Lys Tyr Ile Asp  Glu Ile Phe Asn Ser  Asp Arg Asn 
    1025                 1030                 1035             


Asn Asn  Gln Lys Tyr Lys Ser  Gly Gly Ile Ala Tyr  Lys Tyr Val 
    1040                 1045                 1050             


Asp Phe  Leu Ile Glu Lys Glu  Glu Gly Lys Arg Ala  Gly Lys Asn 
    1055                 1060                 1065             


Lys Val  Lys Lys Arg Ser Glu  Lys Glu Gly Ser Phe  Ile Ile Arg 
    1070                 1075                 1080             


Asn Tyr  Ile Ala His Phe Asn  Tyr Ile Pro Asp Ala  Glu Lys Ser 
    1085                 1090                 1095             


Ile Leu  Glu Ile Leu Glu Glu  Leu Arg Glu Leu Leu  Lys Tyr Asp 
    1100                 1105                 1110             


Arg Lys  Leu Lys Asn Ala Val  Met Lys Ser Val Lys  Asp Ile Phe 
    1115                 1120                 1125             


Lys Glu  Tyr Gly Phe Ile Val  Glu Phe Gly Ile Ser  His Glu Ser 
    1130                 1135                 1140             


Asn Asn  Lys Lys Ile Thr Ile  Asn Lys Val Tyr Ser  Glu Lys Ile 
    1145                 1150                 1155             


Glu His  Leu Lys Lys Ala Lys  Leu Glu Lys Glu Asp  Lys Leu Glu 
    1160                 1165                 1170             


Thr Thr  Arg Asn Ser Glu Asp  Leu Cys Lys Leu Val  Lys Val Met 
    1175                 1180                 1185             


Leu Glu  Tyr Lys Lys Ser 
    1190                 


<210>  724
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  724

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Lys Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Glu Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  725
<211>  1216
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  725

Met Lys Gly Val Pro Asn Met Lys Ile Thr Lys Arg Lys Trp Glu Asp 
1               5                   10                  15      


Val Pro Pro Leu Phe Phe His Arg Asp Lys Asp Ser Gly Arg Leu Ile 
            20                  25                  30          


Arg Gln Asp Asp Arg Glu His Asp Tyr Thr Asp Glu Leu Phe Arg Lys 
        35                  40                  45              


Thr Thr Val Asp Ser Ile Phe Ile Arg Ser Leu Gln Asn Arg Leu Leu 
    50                  55                  60                  


Arg Ser Gln Asp Lys Glu Gly Asn Lys Ile Gly Arg Asn Glu Ile Thr 
65                  70                  75                  80  


Glu Leu Val Glu Asn Leu Cys Lys Gly Ala Glu Ile Gln Lys Ser Ile 
                85                  90                  95      


Asp Glu Ile Lys Asp Ser Lys Ser Asn Val Lys Ala Leu Cys Asp Lys 
            100                 105                 110         


Thr Leu Thr Asp Tyr Gly Lys Ser Phe Ala Ala Glu Glu Gly Arg Thr 
        115                 120                 125             


Thr Leu Tyr Glu Ala Ile Leu Asn Leu Ala Lys Gly Asn Ala Ile Gln 
    130                 135                 140                 


Lys Ala Met Ala Glu Ala Glu Leu Lys Gln Ile His Glu Ala Leu Lys 
145                 150                 155                 160 


Lys Glu Lys Glu Asp Arg Ile Asn Arg Val Gln Asn Ser Ile Lys Asn 
                165                 170                 175     


Asn Lys Ile Pro Leu Lys Val Asn Glu Asp Gly Thr Ile Ser Ala Asn 
            180                 185                 190         


Asn Asp Arg Ala Ser Trp Leu Leu Glu Leu Leu Lys Pro Val Ala Ser 
        195                 200                 205             


Glu His Asp Lys Gly Asp Arg Tyr Pro Val Leu Thr Glu Met Glu Gly 
    210                 215                 220                 


Ile Val Ser Phe Asp Lys Leu Cys Glu Glu Val Arg Asn Lys Ile His 
225                 230                 235                 240 


Gly Arg Lys Gly Arg Thr Arg Ser Ile Ala Met Ser Val Asp Glu Ala 
                245                 250                 255     


Val Lys Glu Tyr Leu Lys Glu Leu Trp Lys Lys His Ala Asp Arg His 
            260                 265                 270         


Arg Asp Met Arg Tyr Tyr Phe Gln Ala Val Lys Glu Tyr Phe Lys Glu 
        275                 280                 285             


Asn Phe Pro Ile Arg Thr Lys Gln Lys Gly Ala Gly Ile Arg Gln Ser 
    290                 295                 300                 


Leu Leu Lys Glu Asp Thr Val Val Ala Arg Leu Leu Asp Pro Lys His 
305                 310                 315                 320 


Met Ala Lys Ala Val Arg Arg Lys Leu Ile Asn Gln Ser Thr Gln Met 
                325                 330                 335     


His Ile Leu Tyr Gly Lys Leu Tyr Glu Tyr Cys Cys Arg Glu Asp Arg 
            340                 345                 350         


Asn Leu Pro Val Asn Ser Glu Thr Leu Gln Leu Ile Gln Val Leu Glu 
        355                 360                 365             


Ala Val Lys Lys Gln Leu Met Thr Ala Val Leu Trp Ser Val Ser Arg 
    370                 375                 380                 


Leu Cys Tyr Phe Tyr Glu Phe Tyr Ser Gly Asp Ile Leu Leu Ala Glu 
385                 390                 395                 400 


Glu Tyr Arg Arg Asp Phe Leu Asn Gln Lys Asn Asp His Lys Asp Ile 
                405                 410                 415     


Gln Ala Cys Lys Glu Lys Leu Gln Asp Phe Phe Pro Leu Ala Glu Leu 
            420                 425                 430         


Gln Glu Lys Ile Arg Glu Cys Ala Asp Lys Asp Ile Asn Asn Ile Lys 
        435                 440                 445             


Asp Lys Ile Thr Asn Asp Val Leu Ala Cys Asn Asn Leu Leu Glu Glu 
    450                 455                 460                 


Cys Val Phe Cys Ile Ser Lys Leu Arg Asn Asn Ile Phe His Tyr Lys 
465                 470                 475                 480 


Asn Leu Ser Phe Thr Gln Ala Leu Lys His Ile Ala Asn Glu Ile Lys 
                485                 490                 495     


Glu Glu Asp Ile Pro Ile Ile Leu Arg Leu Tyr Lys Gln Asp Cys Glu 
            500                 505                 510         


Asn Val Asn Lys Ala Phe Ala Asn Arg Ile Ser Ser Met Asn Leu Pro 
        515                 520                 525             


Leu Tyr Tyr Ser Thr Glu Phe Leu Leu Arg Ile Phe Lys Lys Gln Gly 
    530                 535                 540                 


Ala Glu Leu Ser Leu Tyr Ser Thr Lys Asn Gln Met Thr Pro Ser Phe 
545                 550                 555                 560 


Lys Arg Val Tyr Glu Arg Gly Lys Asn Leu Arg Leu Glu Tyr Glu Arg 
                565                 570                 575     


Glu Pro Met Arg Ser Asn Ile Ala Asn Glu Tyr Asp Lys Asp Pro Gln 
            580                 585                 590         


Ser Asp Tyr Trp Met Arg Trp Phe Ser Gln Phe Ala Thr Gly Thr Val 
        595                 600                 605             


Asp Thr Asn Ala Gly Ile Lys Gly Glu Met Glu Asp Tyr Pro His Ala 
    610                 615                 620                 


Ser Val Asn Leu Gly Ile Glu Ile Glu Ala Gly Thr Asn Ile Asp Ala 
625                 630                 635                 640 


Gln Arg Ala Met Arg Asn Leu Leu Gln Leu Ile Tyr Lys His His Phe 
                645                 650                 655     


Leu Pro Glu Val Gln Lys Asp Glu Thr Val Val Thr Asp Val Ile Pro 
            660                 665                 670         


Lys Val Leu Glu Arg Asn Arg Lys Leu Ser Glu Val Arg Asn Arg Ser 
        675                 680                 685             


Asp Lys Thr Tyr Gly Tyr Lys Glu Ile Glu Glu Leu Cys Lys Lys Asn 
    690                 695                 700                 


Lys Gly Lys Lys Asp Ser Leu Ser Glu Leu Met Lys Asp Leu Gln Arg 
705                 710                 715                 720 


Lys Val Ser Glu Thr Glu Lys Glu Lys Arg Glu Leu Ala Arg Glu Lys 
                725                 730                 735     


Thr Asp Tyr Ala Gln Arg Phe Ile Leu Asp Ile Phe Ala Glu Ala Phe 
            740                 745                 750         


Cys Asn Phe Met Asp Glu Arg Tyr Glu Asp Glu Tyr Gln Glu Ile Met 
        755                 760                 765             


Ser Pro Ile Lys Asn Glu Glu Glu Ala Lys Lys Trp Thr Glu Met Phe 
    770                 775                 780                 


Thr Asp Lys Ala Asp Lys Asp Asn Lys Asp Lys Leu Leu Val Leu Lys 
785                 790                 795                 800 


Thr Ser Phe Asp Lys Asp Asn Val Glu Lys Tyr Leu Leu Val Leu Tyr 
                805                 810                 815     


Pro Leu Met Arg Leu Leu Asp Asp Lys Glu Leu Ser Glu Leu Gln Gln 
            820                 825                 830         


Gln Met Leu Arg Phe Arg Ala Ser Val Ser Gly Trp Gln Gly Gly Thr 
        835                 840                 845             


Asp Phe Ser Glu Asp Ile Ala Met Ala Glu Lys Ile Glu Glu Leu Ala 
    850                 855                 860                 


Glu Leu Val Lys Leu Thr Glu Pro Glu Ser Gln Tyr Ala Glu Glu Ala 
865                 870                 875                 880 


Trp Lys Asn Arg Ala Ile Gly Val Phe Glu Gln Phe Val Glu Gly Lys 
                885                 890                 895     


Met Ala Glu Tyr Gly Thr Phe Tyr Ile Gln Asn Asp Ser Leu Thr Gln 
            900                 905                 910         


Val Pro Arg Gly Asn Met Arg Lys Leu Leu Arg Ser Gly Val Ile Gly 
        915                 920                 925             


Val Tyr Asn Lys Val Leu Ala Ser Cys Lys Gln Ala Thr Lys Ala Asp 
    930                 935                 940                 


Tyr Gly Ala Tyr Ser Gly Asp His Trp Ser Ile Glu Asp Pro Asp Gly 
945                 950                 955                 960 


Asn Pro Ile Lys Ser Ala Glu Gln Ala Gln Ala Leu Leu Gln Arg Leu 
                965                 970                 975     


His Lys Lys Tyr Thr Glu Ser Pro Ser Gln Phe Ser Asp Asp Asp His 
            980                 985                 990         


Lys Leu Tyr Asp Lys Thr Leu Arg  Gln Leu Asp Ala Tyr  Asn Arg Ala 
        995                 1000                 1005             


Met Lys  Asn Leu Ser Phe Gly  Ser Leu Tyr Glu Ile  Cys Arg Ile 
    1010                 1015                 1020             


His Met  Glu Thr Leu Ser Arg  Trp Val Gly Phe Val  Gln Asp Trp 
    1025                 1030                 1035             


Glu Arg  Asp Met Tyr Phe Leu  Leu Leu Ala Trp Thr  Lys Gln Gly 
    1040                 1045                 1050             


Lys Leu  Leu Asn Val Thr Glu  Thr Asp Val Ile Glu  Ile Phe Glu 
    1055                 1060                 1065             


Lys Gly  Ser Val Ile Tyr Lys  Met Asn Lys Lys Leu  Lys Asn Gly 
    1070                 1075                 1080             


Asp Arg  Tyr Ala Phe Thr Ser  Ile Tyr Arg Asn Asn  Asn Asp Glu 
    1085                 1090                 1095             


Lys Leu  Glu Phe Leu Gln Ile  Arg Asn Phe Ile Ala  His Leu His 
    1100                 1105                 1110             


Leu Leu  Arg Lys Ser Glu Trp  Lys Gly Asp Lys Lys  Ala Gly Tyr 
    1115                 1120                 1125             


Ser Val  Ile Glu Asp Tyr Ile  Asn Lys Leu Arg Phe  Leu Leu Ser 
    1130                 1135                 1140             


Tyr Asp  Gln Lys Arg Met Asn  Ala Val Thr Lys Ala  Met Gln Gln 
    1145                 1150                 1155             


Ile Phe  Glu Lys His Lys Val  Ile Val Lys Phe Met  Val Glu Lys 
    1160                 1165                 1170             


Gly Gly  Met Leu Lys Val Lys  Asp Val Lys Pro Gly  Ile Ile Glu 
    1175                 1180                 1185             


His Leu  Lys Gln Thr Lys Arg  Ile Glu Ile Pro Cys  His Gly Glu 
    1190                 1195                 1200             


Arg Phe  Thr Asp Ser Leu Leu  Val Leu Met Lys Tyr  Gln 
    1205                 1210                 1215     


<210>  726
<211>  1210
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  726

Met Lys Ile Thr Lys Arg Lys Trp Glu Asp Val Pro Pro Leu Phe Phe 
1               5                   10                  15      


His Arg Asp Lys Asp Ser Gly Arg Leu Ile Arg Gln Asp Asp Arg Glu 
            20                  25                  30          


His Asp Tyr Thr Asp Glu Leu Phe Arg Lys Thr Thr Val Asp Ser Ile 
        35                  40                  45              


Phe Ile Arg Ser Leu Gln Asn Arg Leu Leu Arg Ser Gln Asp Lys Glu 
    50                  55                  60                  


Gly Asn Lys Ile Gly Arg Asn Glu Ile Thr Glu Leu Val Glu Asn Leu 
65                  70                  75                  80  


Cys Lys Gly Ala Glu Ile Gln Lys Ser Ile Asp Glu Ile Lys Asp Ser 
                85                  90                  95      


Lys Ser Asn Val Lys Ala Leu Cys Asp Lys Thr Leu Thr Asp Tyr Gly 
            100                 105                 110         


Lys Ser Phe Ala Ala Glu Glu Gly Arg Thr Thr Leu Tyr Glu Ala Ile 
        115                 120                 125             


Leu Asn Leu Ala Lys Gly Asn Ala Ile Gln Lys Ala Met Ala Glu Ala 
    130                 135                 140                 


Glu Leu Lys Gln Ile His Glu Ala Leu Lys Lys Glu Lys Glu Asp Arg 
145                 150                 155                 160 


Ile Asn Arg Val Gln Asn Ser Ile Lys Asn Asn Lys Ile Pro Leu Lys 
                165                 170                 175     


Val Asn Glu Asp Gly Thr Ile Ser Ala Asn Asn Asp Arg Ala Ser Trp 
            180                 185                 190         


Leu Leu Glu Leu Leu Lys Pro Val Ala Ser Glu His Asp Lys Gly Asp 
        195                 200                 205             


Arg Tyr Pro Val Leu Thr Glu Met Glu Gly Ile Val Ser Phe Asp Lys 
    210                 215                 220                 


Leu Cys Glu Glu Val Arg Asn Lys Ile His Gly Arg Lys Gly Arg Thr 
225                 230                 235                 240 


Arg Ser Ile Ala Met Ser Val Asp Glu Ala Val Lys Glu Tyr Leu Lys 
                245                 250                 255     


Glu Leu Trp Lys Lys His Ala Asp Arg His Arg Asp Met Arg Tyr Tyr 
            260                 265                 270         


Phe Gln Ala Val Lys Glu Tyr Phe Lys Glu Asn Phe Pro Ile Arg Thr 
        275                 280                 285             


Lys Gln Lys Gly Ala Gly Ile Arg Gln Ser Leu Leu Lys Glu Asp Thr 
    290                 295                 300                 


Val Val Ala Arg Leu Leu Asp Pro Lys His Met Ala Lys Ala Val Arg 
305                 310                 315                 320 


Arg Lys Leu Ile Asn Gln Ser Ile Gln Met His Ile Leu Tyr Gly Lys 
                325                 330                 335     


Leu Tyr Glu Tyr Cys Cys Arg Glu Asp Arg Asn Leu Pro Val Asn Ser 
            340                 345                 350         


Glu Thr Leu Gln Leu Ile Gln Val Leu Glu Ala Phe Lys Lys Gln Leu 
        355                 360                 365             


Met Thr Ala Val Leu Trp Ser Val Ser Arg Leu Cys Tyr Phe Tyr Glu 
    370                 375                 380                 


Phe Tyr Ser Gly Asp Ile Leu Leu Ala Glu Glu Tyr Arg Arg Asp Phe 
385                 390                 395                 400 


Leu Asn Gln Lys Asn Asp His Lys Asp Ile Gln Ala Cys Lys Glu Lys 
                405                 410                 415     


Leu Gln Asp Phe Phe Pro Leu Ala Glu Leu Gln Glu Lys Ile Arg Glu 
            420                 425                 430         


Cys Ala Asp Lys Asp Ile Asn Asn Ile Lys Asp Lys Ile Thr Asn Asp 
        435                 440                 445             


Val Leu Ala Cys Asn Asn Leu Leu Glu Glu Cys Val Phe Cys Ile Ser 
    450                 455                 460                 


Lys Leu Arg Asn Asn Ile Phe His Tyr Lys Asn Leu Ser Phe Thr Gln 
465                 470                 475                 480 


Ala Leu Lys His Ile Ala Asn Glu Ile Lys Glu Glu Asp Ile Pro Ile 
                485                 490                 495     


Ile Leu Arg Leu Tyr Lys Gln Asp Cys Glu Asn Val Asn Lys Ala Phe 
            500                 505                 510         


Ala Asn Arg Ile Ser Ser Met Asn Leu Pro Leu Tyr Tyr Ser Thr Glu 
        515                 520                 525             


Phe Leu Leu Arg Ile Phe Lys Lys Gln Gly Ala Glu Leu Ser Leu Tyr 
    530                 535                 540                 


Ser Thr Lys Asn Gln Met Thr Pro Ser Phe Lys Arg Val Tyr Glu Arg 
545                 550                 555                 560 


Gly Lys Asn Leu Arg Leu Glu Tyr Glu Arg Glu Pro Met Arg Ser Asn 
                565                 570                 575     


Ile Ala Asn Glu Tyr Asp Lys Asp Pro Gln Ser Asp Tyr Trp Met Arg 
            580                 585                 590         


Trp Phe Ser Gln Phe Ala Thr Gly Thr Val Asp Thr Asn Ala Gly Ile 
        595                 600                 605             


Lys Gly Glu Met Glu Asp Tyr Pro His Ala Ser Val Asn Leu Gly Ile 
    610                 615                 620                 


Glu Ile Glu Ala Gly Thr Asn Ile Asp Ala Gln Arg Ala Met Arg Asn 
625                 630                 635                 640 


Leu Leu Gln Leu Ile Tyr Lys His His Phe Leu Pro Glu Val Gln Lys 
                645                 650                 655     


Asp Glu Thr Val Val Thr Asp Val Ile Pro Lys Val Leu Glu Arg Asn 
            660                 665                 670         


Arg Lys Leu Ser Glu Val Arg Asn Arg Ser Asp Lys Thr Tyr Gly Tyr 
        675                 680                 685             


Lys Glu Ile Glu Glu Leu Cys Lys Lys Asn Lys Gly Lys Lys Asp Ser 
    690                 695                 700                 


Leu Ser Glu Leu Met Lys Asp Leu Gln Arg Lys Val Ser Glu Thr Glu 
705                 710                 715                 720 


Lys Glu Lys Arg Glu Leu Ala Arg Glu Lys Thr Asp Tyr Ala Gln Arg 
                725                 730                 735     


Phe Ile Leu Asp Ile Phe Ala Glu Ala Phe Cys Asn Phe Met Asp Glu 
            740                 745                 750         


Arg Tyr Glu Asp Glu Tyr Gln Glu Ile Met Ser Pro Ile Lys Asn Glu 
        755                 760                 765             


Glu Glu Ala Lys Lys Trp Thr Glu Met Phe Thr Asp Lys Ala Asp Lys 
    770                 775                 780                 


Asp Asn Lys Asp Lys Leu Leu Val Leu Lys Thr Ser Phe Asp Lys Asp 
785                 790                 795                 800 


Asn Val Glu Lys Tyr Leu Leu Ala Leu Tyr Pro Leu Met Arg Leu Leu 
                805                 810                 815     


Asp Asp Lys Glu Leu Ser Glu Leu Gln Gln Gln Met Leu Arg Phe Arg 
            820                 825                 830         


Ala Ser Val Ser Gly Trp Gln Gly Gly Thr Asp Phe Ser Glu Asp Ile 
        835                 840                 845             


Ala Met Ala Glu Lys Ile Glu Glu Leu Ala Glu Leu Val Lys Leu Thr 
    850                 855                 860                 


Glu Pro Glu Ser Gln Tyr Ala Glu Glu Ala Trp Lys Asn Arg Ala Ile 
865                 870                 875                 880 


Gly Val Phe Glu Gln Phe Val Glu Gly Lys Met Ala Glu Tyr Gly Thr 
                885                 890                 895     


Phe Tyr Ile Gln Asn Asp Ser Leu Thr Gln Val Pro Arg Gly Asn Met 
            900                 905                 910         


Arg Lys Leu Leu Arg Ser Gly Val Ile Gly Val Tyr Asn Lys Val Leu 
        915                 920                 925             


Ala Ser Cys Lys Gln Ala Thr Lys Ala Asp Tyr Gly Ala Tyr Ser Gly 
    930                 935                 940                 


Asp His Trp Ser Ile Glu Asp Pro Asp Gly Asn Pro Ile Lys Ser Ala 
945                 950                 955                 960 


Glu Gln Ala Gln Ala Leu Leu Gln Arg Leu His Lys Lys Tyr Thr Glu 
                965                 970                 975     


Ser Pro Ser Gln Phe Ser Asp Asp Asp His Lys Leu Tyr Asp Lys Thr 
            980                 985                 990         


Leu Arg Gln Leu Asp Ala Tyr Asn  Arg Ala Met Lys Asn  Leu Ser Phe 
        995                 1000                 1005             


Gly Ser  Leu Tyr Glu Ile Cys  Arg Ile His Met Glu  Thr Leu Ser 
    1010                 1015                 1020             


Arg Trp  Val Gly Phe Val Gln  Asp Trp Glu Arg Asp  Met Tyr Phe 
    1025                 1030                 1035             


Leu Leu  Leu Ala Trp Thr Lys  Gln Gly Lys Leu Leu  Asn Val Thr 
    1040                 1045                 1050             


Glu Thr  Asp Val Ile Glu Ile  Phe Glu Lys Gly Ser  Val Ile Tyr 
    1055                 1060                 1065             


Lys Met  Asn Lys Lys Leu Lys  Asn Gly Asp Arg Tyr  Ala Phe Thr 
    1070                 1075                 1080             


Ser Ile  Tyr Arg Asn Asn Asn  Asp Glu Lys Leu Glu  Phe Leu Gln 
    1085                 1090                 1095             


Ile Arg  Asn Phe Ile Ala His  Leu His Leu Leu Arg  Lys Ser Glu 
    1100                 1105                 1110             


Trp Lys  Gly Asp Lys Lys Ala  Gly Tyr Ser Val Ile  Glu Asp Tyr 
    1115                 1120                 1125             


Ile Asn  Lys Leu Arg Phe Leu  Leu Ser Tyr Asp Gln  Lys Arg Met 
    1130                 1135                 1140             


Asn Ala  Val Thr Lys Ala Met  Gln Gln Ile Phe Glu  Lys His Lys 
    1145                 1150                 1155             


Val Ile  Val Lys Phe Met Val  Glu Lys Gly Gly Met  Leu Lys Val 
    1160                 1165                 1170             


Lys Asp  Val Lys Pro Gly Ile  Ile Glu His Leu Lys  Gln Thr Lys 
    1175                 1180                 1185             


Arg Ile  Glu Ile Pro Cys His  Gly Glu Arg Phe Thr  Asp Ser Leu 
    1190                 1195                 1200             


Leu Val  Leu Met Lys Tyr Gln  
    1205                 1210 


<210>  727
<211>  1100
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  727

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Tyr Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Leu Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Val 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Asn Phe Tyr Glu Lys Asp Val Ile Ile Lys Tyr Leu Lys Asn Thr Lys 
    530                 535                 540                 


Phe Asn Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Asn Lys Ile Asp Asp Leu Arg Asn Thr Leu Lys Phe Ser Trp 
                565                 570                 575     


Lys Ile Pro Lys Asp Lys Glu Glu Lys Asp Ala Gln Ile Tyr Leu Leu 
            580                 585                 590         


Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn Lys Phe Val Lys Asn Ser 
        595                 600                 605             


Lys Asp Phe Phe Lys Ile Thr Asp Glu Val Ile Lys Ile Asn Lys Gln 
    610                 615                 620                 


Arg Asn Gln Lys Thr Gly Tyr Tyr Lys Tyr Gln Lys Phe Glu Asn Ile 
625                 630                 635                 640 


Glu Lys Thr Val Pro Val Glu Tyr Leu Ala Ile Ile Gln Ser Arg Asp 
                645                 650                 655     


Thr Ile Asn Asn Gln Asp Lys Glu Glu Lys Asn Thr Tyr Ile Asp Phe 
            660                 665                 670         


Val Gln Gln Ile Phe Leu Lys Gly Phe Ile Asp Tyr Leu Asn Lys Asn 
        675                 680                 685             


Asn Leu Lys Tyr Ile Glu Asn Asn Asn Asn Asn Asp Ile Phe Ser Arg 
    690                 695                 700                 


Ile Lys Ile Lys Lys Asp Ser Lys Glu Arg Tyr Asp Lys Ile Leu Lys 
705                 710                 715                 720 


Asn Tyr Glu Lys Asn Asn Arg Asn Lys Glu Ile Pro Tyr Glu Ile Asn 
                725                 730                 735     


Glu Phe Val Arg Glu Ile Lys Leu Gly Lys Ile Leu Lys Tyr Thr Glu 
            740                 745                 750         


Arg Leu Asn Met Phe Tyr Leu Ile Leu Lys Leu Leu Asn His Lys Glu 
        755                 760                 765             


Leu Thr Asn Leu Lys Gly Ser Leu Glu Lys Tyr Gln Ser Ala Asn Lys 
    770                 775                 780                 


Glu Glu Thr Phe Ser Asp Glu Leu Glu Leu Ile Asn Leu Leu Asn Leu 
785                 790                 795                 800 


Asp Asn Asn Arg Val Thr Glu Asp Phe Glu Leu Glu Ala Asp Glu Ile 
                805                 810                 815     


Gly Lys Phe Leu Asp Phe Asn Gly Asp Lys Val Lys Asp Arg Lys Glu 
            820                 825                 830         


Leu Lys Lys Phe Asp Thr Lys Lys Ile Tyr Phe Asp Gly Glu Asn Ile 
        835                 840                 845             


Ile Lys His Arg Ala Phe Tyr Asn Ile Lys Lys Tyr Gly Met Leu Asn 
    850                 855                 860                 


Leu Leu Glu Lys Ile Ala Asp Lys Ala Lys Tyr Lys Ile Ser Ile Glu 
865                 870                 875                 880 


Glu Leu Arg Asn Tyr Ser Asn Lys Lys Asn Glu Ile Glu Lys Asn His 
                885                 890                 895     


Thr Thr Gln Glu Asn Leu His Arg Lys Tyr Ala Arg Pro Arg Lys Asp 
            900                 905                 910         


Glu Lys Phe Thr Asp Glu Asp Tyr Lys Lys Tyr Glu Lys Ala Ile Arg 
        915                 920                 925             


Asn Ile Gln Gln Tyr Thr His Leu Lys Asn Lys Val Glu Phe Asn Glu 
    930                 935                 940                 


Leu Asn Leu Leu Gln Gly Leu Leu Leu Arg Ile Leu His Arg Leu Val 
945                 950                 955                 960 


Gly Tyr Thr Ser Ile Trp Glu Arg Asp Leu Arg Phe Arg Leu Lys Gly 
                965                 970                 975     


Glu Phe Pro Glu Asn Gln Tyr Ile Glu Glu Ile Phe Asn Phe Asn Asn 
            980                 985                 990         


Lys Gln Asn Val Lys Tyr Lys Ser  Gly Gln Ile Val Glu  Lys Tyr Ile 
        995                 1000                 1005             


Lys Phe  Tyr Lys Glu Leu His  Gln Asn Asp Glu Val  Lys Ile Asn 
    1010                 1015                 1020             


Lys Tyr  Ser Ser Val Asn Ile  Lys Val Leu Lys Gln  Glu Lys Lys 
    1025                 1030                 1035             


Asp Leu  Tyr Ile Arg Asn Tyr  Ile Ala His Phe Asn  Tyr Ile Pro 
    1040                 1045                 1050             


His Ala  Glu Ile Ser Leu Leu  Glu Val Leu Glu Asn  Leu Arg Lys 
    1055                 1060                 1065             


Leu Leu  Ser Tyr Asp Arg Lys  Leu Lys Asn Ala Val  Met Lys Ser 
    1070                 1075                 1080             


Val Val  Asp Ile Leu Lys Glu  Tyr Gly Phe Val Ala  Thr Phe Lys 
    1085                 1090                 1095             


Ile Gly  
    1100 


<210>  728
<211>  1393
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  728

Met Gly Asn Leu Phe Gly His Lys Lys Trp Tyr Lys Val Asp Lys Ile 
1               5                   10                  15      


Ile Lys Asp Lys Lys Gly Lys Glu Ser Thr Ile Lys Gln Glu Val Arg 
            20                  25                  30          


Ile Lys Arg Asn Tyr Ser Val Asp Arg Tyr Thr Leu Asn Thr Asn Asn 
        35                  40                  45              


Lys Glu Lys Asn Asn Ile Asn Asn Glu Asp Phe Val Asn Gln Phe Ile 
    50                  55                  60                  


Glu Tyr Lys Thr Asn Asn Asp Ile Leu Lys Lys Phe Thr Lys Lys Phe 
65                  70                  75                  80  


His Met Gly Asn Ile Leu Phe Lys Leu Lys Ala Glu Glu Ser Val Arg 
                85                  90                  95      


Glu Ile Arg Asn Tyr Asn Asp Phe Leu Glu Lys Glu Lys Ala Ile Leu 
            100                 105                 110         


Glu Ile Glu Ile Tyr Gln Gln Ser Glu Glu Leu Arg Lys Lys Glu Asn 
        115                 120                 125             


Ile Thr Lys Lys Asp Ile Ile Asp Lys Val Ile Glu Asp Lys Ile Thr 
    130                 135                 140                 


Glu Asn Ser Asn Glu Ile Lys Met Gln Ile Lys Leu Glu Lys Asn Asn 
145                 150                 155                 160 


Phe Glu Glu Ile Arg Ile Tyr Ile Asn Lys Glu Leu Gly Gln Tyr Asn 
                165                 170                 175     


Ile Lys Leu Lys Asn Ile Asp Asn Asp Glu Leu Asn Leu Lys Arg Glu 
            180                 185                 190         


Thr Tyr Glu Thr Leu Lys Ser Ile Asn Ala Asn Leu Tyr Ile Ile Thr 
        195                 200                 205             


Lys Asn Thr Ile Asn Asn Ala Asp Phe Lys Lys Arg Asn Tyr Glu Thr 
    210                 215                 220                 


Tyr Leu Lys Lys Ser Met Gly Lys Tyr Leu Arg Lys Asn Ile Asn Lys 
225                 230                 235                 240 


Lys Pro Glu Asn Thr Phe Leu Lys Ser Leu Ser Glu Asn Phe Lys Lys 
                245                 250                 255     


Ile Gln Asn Asn Ile Lys Lys Asn Glu Glu Ile Ile Asn Phe Ile Lys 
            260                 265                 270         


Tyr Tyr Ser Ser Ile Asn Gly Asn Lys Thr Val Ser Glu Asn Lys Lys 
        275                 280                 285             


Thr Phe Leu Glu Lys Ile Leu Asn Thr Glu Val Ser Ile Ser Glu Asn 
    290                 295                 300                 


Asp Ile Ile Asp Phe Ile Ile Gly Glu Leu Lys Phe Tyr Gly Ile Ile 
305                 310                 315                 320 


Lys Arg Ile Glu Glu Leu Gln Glu Lys Thr Ala Asp Arg Thr Glu Glu 
                325                 330                 335     


Asp Ile Lys Asn Thr Tyr Ile Asn Thr Tyr Val Ser Leu Asp Lys His 
            340                 345                 350         


Glu Lys Phe Lys Lys Tyr Asn Arg Asn Lys Lys Asp Thr Ile Val Lys 
        355                 360                 365             


Ser Phe Ile Lys Asp Ile Lys Asp Asn Thr Met Lys Gln Lys Ile Asn 
    370                 375                 380                 


His Ile Leu Asn Lys Phe Lys Ile Glu Glu Leu Ile Glu Lys Leu Lys 
385                 390                 395                 400 


Glu Asn Thr Glu Asn Lys Asn Phe Asp Thr Glu Ile Phe Gly Ile Phe 
                405                 410                 415     


Lys Thr His Tyr Gln Asn Ile Phe Ser Ser Glu Lys Phe Ser Asn Lys 
            420                 425                 430         


Ser Asp Glu Glu Lys Glu Leu Tyr Lys Ile Ile Tyr Arg Tyr Leu Lys 
        435                 440                 445             


Gly Arg Ile Glu Lys Ile Leu Ile Asn Glu Gln Lys Val Arg Leu Lys 
    450                 455                 460                 


Lys Met Glu Lys Ile Glu Val Glu Lys Ile Leu Asn Glu Ser Ile Leu 
465                 470                 475                 480 


Ser Glu Lys Ile Leu Lys Arg Val Lys Gln Tyr Thr Leu Glu His Ile 
                485                 490                 495     


Met Tyr Leu Gly Lys Leu Arg His Asn Asp Ile Val Lys Met Thr Val 
            500                 505                 510         


Asn Thr Asn Asp Phe Ser Arg Leu His Ala Lys Glu Glu Leu Asp Leu 
        515                 520                 525             


Glu Leu Ile Thr Phe Phe Ala Ser Thr Asn Met Glu Leu Asn Lys Ile 
    530                 535                 540                 


Phe Asn Gly Lys Glu Lys Ile Thr Asp Phe Phe Gly Phe Asn Leu Asn 
545                 550                 555                 560 


Gly Gln Lys Ile Thr Leu Lys Glu Lys Val Pro Asn Phe Lys Leu Asn 
                565                 570                 575     


Ile Leu Lys Lys Leu Asn Phe Ile Asn Asn Glu Asn Asn Ile Asp Glu 
            580                 585                 590         


Lys Leu Ser His Phe Tyr Ser Phe Gln Lys Glu Gly Tyr Leu Leu Arg 
        595                 600                 605             


Asn Lys Ile Leu His Asn Ser Tyr Gly Asn Ile Gln Glu Thr Lys Asn 
    610                 615                 620                 


Ser Glu Glu Lys Tyr Lys Asn Val Lys Asn Leu Ile Asp Glu Leu Lys 
625                 630                 635                 640 


Val Ser Asp Glu Glu Ile Ser Lys Ser Leu Asn Leu Asp Val Ile Phe 
                645                 650                 655     


Glu Gly Lys Asn Asn Ile Ile Ile Glu Ile Asn Lys Leu Gln Thr Gly 
            660                 665                 670         


Lys Tyr Lys Asp Lys Lys Tyr Leu Pro Ser Phe Ser Lys Ile Val Pro 
        675                 680                 685             


Glu Ile Thr Arg Lys Phe Arg Glu Ile Asn Lys Asp Lys Ser Phe Asp 
    690                 695                 700                 


Ile Glu Ser Glu Lys Ile Ile Leu Asn Ala Val Gln Tyr Val Asn Lys 
705                 710                 715                 720 


Ile Leu Tyr Glu Lys Ile Thr Ser Asn Glu Glu Asn Glu Phe Ile Lys 
                725                 730                 735     


Thr Leu Pro Asp Lys Leu Val Lys Lys Asn Asn Asn Gln Glu Asn Lys 
            740                 745                 750         


Asn Ser Leu Ser Ile Glu Glu Tyr Tyr Lys Asn Ala Gln Ile Ser Ser 
        755                 760                 765             


Ser Lys Gly Asp Lys Lys Ala Ile Lys Lys Tyr Gln Asn Lys Val Thr 
    770                 775                 780                 


Asn Ala Tyr Ile Glu Tyr Leu Glu Asn Thr Phe Ala Glu Val Ile Asp 
785                 790                 795                 800 


Phe Ser Asn Phe Asn Leu Asn Phe Asp Glu Ile Lys Thr Lys Ile Glu 
                805                 810                 815     


Glu Arg Lys Tyr Ser Lys Ser Lys Ile Thr Val Asp Ser Ile Ser Thr 
            820                 825                 830         


Asn Ile Asn Ile Thr Asn Asp Ile Glu Tyr Ile Ile Ser Ile Phe Ala 
        835                 840                 845             


Leu Leu Asn Ser Asn Thr Tyr Ile Asn Lys Ile Arg Asn Arg Phe Phe 
    850                 855                 860                 


Ala Thr Ser Val Trp Leu Asn Thr Gln Lys Tyr Glu Asn Ile Ile Asp 
865                 870                 875                 880 


Ile Leu Asp Lys Ile Leu Ser Ile Asn Leu Leu Arg Glu Asn Asn Ile 
                885                 890                 895     


Ala Asp Ile Leu Asp Leu Lys Asn Thr Ile Ile Glu Ala Lys Ile Val 
            900                 905                 910         


Glu Asn Asn Glu Glu Cys Ile Lys Asn Tyr Ile Phe Glu Asn Asn Glu 
        915                 920                 925             


Glu Glu Leu Lys Lys Arg Leu Phe Cys Glu Glu Leu Val Asn Lys Glu 
    930                 935                 940                 


Asp Val Leu Lys Ile Phe Glu Asp Lys Asn Phe Lys Phe Lys Asn Phe 
945                 950                 955                 960 


Ile Lys Lys Thr Val Asn Glu Asn Phe Thr Ile Asp Phe Asp Ile Leu 
                965                 970                 975     


Phe Asn Leu Glu Cys Asn Ser Glu Leu Asn Ala Lys Lys Val Ile Gly 
            980                 985                 990         


Gln Asn Ser Gln Arg Leu Asn Leu  Phe Ile Lys Asn Thr  Ile Asp Glu 
        995                 1000                 1005             


Tyr Lys  Ser Lys Ile Lys Thr  Ser Phe Ser Ser Glu  Phe Leu Glu 
    1010                 1015                 1020             


Lys Tyr  Lys Lys Glu Ile Asp  Asn Leu Val Glu Asp  Thr Glu Thr 
    1025                 1030                 1035             


Glu Asn  Lys Asn Lys Phe Glu  Lys Ile Tyr Tyr Pro  Glu Glu His 
    1040                 1045                 1050             


Lys Asn  Glu Leu Tyr Ile Tyr  Lys Lys Asn Leu Phe  Leu Asn Ile 
    1055                 1060                 1065             


Gly Asn  Pro Asn Phe Asp Lys  Ile Tyr Glu Leu Ile  Ser Lys Asp 
    1070                 1075                 1080             


Ile Lys  Asn Ala Asn Met Glu  Ile Leu Phe Asn Asp  Asp Ile Arg 
    1085                 1090                 1095             


Lys Asn  Lys Ile Ala Glu Ile  Asp Val Ile Leu Lys  Lys Leu Asn 
    1100                 1105                 1110             


Asp Lys  Leu Ser Gly Tyr Ser  Lys Glu Tyr Lys Glu  Lys Tyr Ile 
    1115                 1120                 1125             


Lys Lys  Leu Lys Glu Asn Gln  Glu Asn Ser Asp Phe  Phe Thr Lys 
    1130                 1135                 1140             


Asn Ile  Gln Asn Glu Asn Tyr  Asn Ser Phe Glu Glu  Phe Lys Glu 
    1145                 1150                 1155             


Asp Tyr  Asn Lys Val Ser Glu  Tyr Lys Lys Ile Arg  Asp Leu Val 
    1160                 1165                 1170             


Glu Phe  Asn Tyr Leu Asn Lys  Ile Glu Ser Tyr Leu  Ile Asp Ile 
    1175                 1180                 1185             


Asn Trp  Lys Leu Ala Ile Gln  Met Ala Arg Phe Glu  Arg Asp Met 
    1190                 1195                 1200             


His Tyr  Ile Val Asn Gly Leu  Arg Glu Leu Gly Ile  Ile Lys Leu 
    1205                 1210                 1215             


Asn Gly  Tyr Asn Thr Gly Ile  Ser Arg Ala Tyr Pro  Lys Arg Asp 
    1220                 1225                 1230             


Gly Ser  Asp Asp Phe Tyr Thr  Thr Thr Ala Tyr Tyr  Lys Phe Phe 
    1235                 1240                 1245             


Asp Glu  Glu Ser Tyr Lys Lys  Phe Glu Lys Ile Cys  Tyr Lys Phe 
    1250                 1255                 1260             


Gly Ile  Asp Leu Ser Glu Asn  Ser Glu Ile Asn Lys  Pro Glu Asn 
    1265                 1270                 1275             


Glu Ser  Ile Arg Asn Tyr Ile  Ser His Phe Tyr Ile  Val Arg Asn 
    1280                 1285                 1290             


Pro Phe  Ala Asp Tyr Ser Ile  Val Glu Gln Ile Asp  Arg Val Ser 
    1295                 1300                 1305             


Asn Leu  Leu Ser Tyr Ser Thr  Arg Tyr Asn Asn Ser  Thr Tyr Ala 
    1310                 1315                 1320             


Ser Val  Phe Glu Val Phe Lys  Lys Asp Val Asp Leu  Asp Tyr Asp 
    1325                 1330                 1335             


Glu Leu  Lys Lys Lys Phe Lys  Leu Ile Gly Asp Asn  Asp Ile Leu 
    1340                 1345                 1350             


Glu Lys  Leu Met Lys Ser Lys  Lys Val Ser Val Leu  Glu Leu Glu 
    1355                 1360                 1365             


Ser Tyr  Asn Tyr Asp Tyr Val  Lys Asn Leu Ile Ile  Lys Leu Leu 
    1370                 1375                 1380             


Thr Lys  Lys Glu Asn Thr Asn  Asp Thr Leu 
    1385                 1390             


<210>  729
<211>  1346
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  729

Met Lys Ile Thr Lys Val Arg Val Lys Glu Asn Asn Glu Gln Tyr Ser 
1               5                   10                  15      


Thr Gln His Tyr Arg Asn Val Tyr Asn Gly Met Leu His Lys Val Ser 
            20                  25                  30          


Asn Lys His Tyr Ile Asp Thr Met Glu His Leu Lys Asn Ile Asn Asn 
        35                  40                  45              


Ser Asn Asn Lys Ala Leu Asp Lys Ser Phe Ile Asp Arg Leu Val Val 
    50                  55                  60                  


Pro Lys Glu Asn Lys Lys Asn Tyr Asp Pro Ala Val His Ala Phe Leu 
65                  70                  75                  80  


Thr Glu Ile Tyr Asn Gly Gln Asn Ile Asn Glu Cys Ala Lys Lys Leu 
                85                  90                  95      


Gln Asn Asp Ile Lys Asn Lys Asp Cys Thr Ala Leu Ser Ser Lys Gly 
            100                 105                 110         


Lys Val Phe Cys Lys Gly Lys Ile Lys Lys Ile Ile Glu Asp Ile Ile 
        115                 120                 125             


Asp Asn Lys Ala Ile Thr Tyr Asp Asp Leu Thr Gln Ile Ser Lys Ala 
    130                 135                 140                 


Met Gln Ser Lys Ala Asp Asn His Lys Lys Gln Ile Cys Lys Ser Ile 
145                 150                 155                 160 


Val Asn Asn Asn Ile Asn Val Asp Pro Ser Ser Arg Leu Arg Gln Tyr 
                165                 170                 175     


Phe Ile Asn Ser Leu Val Val Ser Lys Asp Asp Val Asn Tyr Asn Asp 
            180                 185                 190         


Arg Val His Asp Phe Ile His Lys Leu Tyr Ile Ser Asn Ile Asp Ile 
        195                 200                 205             


Ser Lys Leu Lys Lys Tyr Pro Leu Lys Asn Val Ala Thr Glu Gln Asp 
    210                 215                 220                 


Val Gln Gln Thr Leu Ser Ala Glu Gly Arg Ala Phe Cys Asp Gly Lys 
225                 230                 235                 240 


Leu Ser Lys Val Ile Thr Ala Phe Ala Thr Asn Asp Ile Lys Gly Ile 
                245                 250                 255     


Thr Gln Asn Asp Leu Asp Cys Ile Lys Gln Lys Ile Asn Glu Ala Thr 
            260                 265                 270         


Leu Ser Ser Ile Ser Gly Asp Asn Ala Asn Leu Tyr Glu Arg Tyr Ser 
        275                 280                 285             


Asp Tyr Asn Asn Val Asn Pro Asn Cys Ser Arg Asn Ile Phe Glu Lys 
    290                 295                 300                 


Asn Ile Asn Glu Asn Tyr Asn Gln Lys Arg Leu Ser His Gly Glu Trp 
305                 310                 315                 320 


Leu Val Gln Phe Ile Ala Asn Asn Ser Ile Asn Asp Glu Arg Phe Lys 
                325                 330                 335     


Thr Phe Glu Ser Leu Phe Gln Tyr Asp Glu Leu Ser Cys Lys Leu Thr 
            340                 345                 350         


Glu Cys Leu Lys Lys Tyr Glu Thr Glu Leu Asn Lys Leu Asn Ser Ile 
        355                 360                 365             


Glu Glu Gly Asp Lys Glu Gly Gln Lys Gln Ile Arg Gln Tyr Lys Gln 
    370                 375                 380                 


Glu Cys Leu Thr Glu Ile His Gly Ile Tyr Lys Gln His Glu Val Glu 
385                 390                 395                 400 


His Tyr Lys Asp Lys Glu Gly Glu Ser Thr Lys Lys His Glu Met Tyr 
                405                 410                 415     


Phe Ala Tyr Tyr Ile Arg Glu Val Arg Glu Tyr Phe Asn His Tyr Phe 
            420                 425                 430         


Pro Leu Gln Asn Asn Thr Arg Lys Gln Ser Ile Asn Lys Arg Asp Ile 
        435                 440                 445             


Lys Asn Phe Ile Thr Tyr Ile Asp Lys Tyr Ala Asn Ile Glu Lys Ile 
    450                 455                 460                 


Lys Thr Ile Val Lys Tyr Gln Ile Leu Asn Lys Leu Thr Ser Gln Leu 
465                 470                 475                 480 


Ile Leu Glu Gly Lys Leu Thr Tyr Phe Ser Asp Ser Phe Asn Lys Glu 
                485                 490                 495     


Met Asn Gln Phe Thr Ser Asp Asp Leu Glu Leu Ile His Val Gln Glu 
            500                 505                 510         


Ala Phe Lys Lys Gln Leu Leu Thr Ser Ile Ala Trp Ser Thr Ser Gln 
        515                 520                 525             


Leu Arg Phe Ile Met Leu Gly Glu Gln Asp Thr Thr Gln Leu Gly Asp 
    530                 535                 540                 


Ile Leu Leu Gln Gly Asn Phe Asp Lys Ala Leu Lys Thr Ala Glu Asn 
545                 550                 555                 560 


Asn Lys Tyr Glu Thr Thr Lys Arg Leu Lys Trp Phe Leu Asn Asn Ile 
                565                 570                 575     


Leu Asn Asp Asn Gly Glu Thr Ile Ile Thr Glu Asp Asn Ile Ser Asn 
            580                 585                 590         


Leu Leu Thr Ser Ile His Lys Tyr Ile Tyr Asn Asn Arg Asn Lys Ile 
        595                 600                 605             


Tyr His Phe Ser Lys Glu Tyr Phe Leu Asp Asp Lys Asn Phe Tyr Ile 
    610                 615                 620                 


Asp Asp Asn Asp Glu Leu Thr Lys Lys Leu Tyr Ala Asn Asp Lys Asp 
625                 630                 635                 640 


Ser Val Asn Ala Ala Phe Lys Glu Lys Ile Arg Ser Met Asn Leu Tyr 
                645                 650                 655     


Thr Cys Tyr Asn Ser Gln Thr Gln Gln Asp Ile Leu Gly Lys Val Asn 
            660                 665                 670         


Phe Ser Leu Ser His Pro Ser Ile Ser Ile Val Pro Ser Phe Lys Asn 
        675                 680                 685             


Val Tyr Asn Lys Gly Lys Asn Leu Gln Glu Gly Asn Ala Asp Ala Lys 
    690                 695                 700                 


Lys Ser Gln Glu Glu Gly Ile Gln Gly Leu Glu Trp Phe Val Leu Pro 
705                 710                 715                 720 


Ala Glu Asp Glu Lys Thr Leu Leu Asn Ser Ser Glu Glu Val Arg Val 
                725                 730                 735     


Tyr Arg Asn Phe Leu Gln Leu Ile Tyr Glu Tyr Ala Phe Leu Pro Ser 
            740                 745                 750         


Ile Asp Lys Ser Gly Ile Ala Asn Leu Lys Lys Leu His His Cys Val 
        755                 760                 765             


Ile Thr Leu Asn Lys Glu Phe Ser Lys Asn Arg Gln Thr Glu Ala Asn 
    770                 775                 780                 


Ile Glu Arg Asp Glu Gln Asn Gln Lys Glu Ile Lys Asp Asn Glu Phe 
785                 790                 795                 800 


Lys Tyr Glu Ile Ile Glu Thr Phe Gly Lys Asp Phe Phe Lys Asp Lys 
                805                 810                 815     


Ile Gln Asn Ser Ile Thr Lys Glu Asp Cys Lys Asp Tyr Phe Lys Glu 
            820                 825                 830         


Leu Gln Ser Phe Val Val Lys Lys Glu Asn Glu Asn Gln Glu Asn Lys 
        835                 840                 845             


Ala Gln Gly Arg Ser Lys Thr Gly Ser Asp Lys Asp Lys Asn Ile Tyr 
    850                 855                 860                 


Val Asp Phe Val Arg Asp Leu Tyr Val Phe Ala Phe Asn Gln Phe Leu 
865                 870                 875                 880 


Glu Gly Lys Tyr Lys Leu Val Pro Gly Ile Lys Lys Gln Leu Arg Ser 
                885                 890                 895     


Pro Gln Tyr Asn Glu Glu Ala Thr Phe Asp Asp Lys Leu Lys Ile Thr 
            900                 905                 910         


Val Asn Thr Ser Tyr Leu Pro Ser Thr Ala Pro Gln Leu Tyr Leu Met 
        915                 920                 925             


Ala Arg Leu Leu Asp Ala Asp Gln Leu Asn Asn Leu Arg His Gln Phe 
    930                 935                 940                 


Met Arg Tyr Lys Glu Ser Val Thr Gln Ile Tyr Lys Glu Asp Ala Val 
945                 950                 955                 960 


Gly Ile Gly Glu Lys Val Lys Tyr Ile Ile Asp Met Leu Thr Met Val 
                965                 970                 975     


Asn Leu Thr Gly Val Asn Tyr Thr Glu Ser Leu Lys Asn Phe Leu Asn 
            980                 985                 990         


Asp Asn Ser Gly Glu Ile Ile Lys  Gln Tyr Lys Asn Phe  Met Asp Asn 
        995                 1000                 1005             


Asp Val  Asn Pro Asp Asp Ile  Lys Tyr Lys Asp Leu  Tyr Val Gln 
    1010                 1015                 1020             


Thr Asp  Gly Glu Thr Leu Ile  Leu His Lys Gly Ile  Gly Ser Ala 
    1025                 1030                 1035             


Tyr Arg  Ser Gly Cys Leu Ser  Leu Tyr Glu Lys Leu  Tyr Gly Thr 
    1040                 1045                 1050             


Asn Arg  Ile Ser Ser Lys Asp  Cys Asn Asp Tyr Leu  Asp Trp Ile 
    1055                 1060                 1065             


Lys Thr  Asp Ala Thr Gly Ser  Ser Lys Ile Glu Val  Leu Gln Lys 
    1070                 1075                 1080             


Val Arg  Glu Met Leu His Asp  Glu Ile Thr Lys Arg  Asp Lys Thr 
    1085                 1090                 1095             


Asp Arg  Ile Gly Lys Tyr Lys  Lys Ala Val Glu Lys  Cys Asp Glu 
    1100                 1105                 1110             


Tyr Asn  Lys Leu Lys Asn Lys  Val Thr Phe Asn Asp  Leu Tyr Ser 
    1115                 1120                 1125             


Leu Gly  Gln Leu His Arg Asp  Ile Leu Ser Arg Phe  Ile Gly Phe 
    1130                 1135                 1140             


Ala Val  Asp Trp Glu Arg Asp  Met His Phe Leu Leu  Ile Ser Leu 
    1145                 1150                 1155             


Thr Lys  Tyr Gly Leu Met Lys  Asp Ala Lys Glu Asn  Pro Lys Tyr 
    1160                 1165                 1170             


Ile Asn  Lys Thr Ile Val Glu  Phe Ile Ser Asp Lys  Phe Phe Asn 
    1175                 1180                 1185             


His Glu  Asn Gly Gly Ala Val  Glu Asn Ile Cys Lys  Glu Phe Gly 
    1190                 1195                 1200             


Gly Asn  Pro Asp Leu Leu Lys  Val Phe Lys Ser Leu  Tyr Gln Ser 
    1205                 1210                 1215             


Asn Asn  Ile Asp Ser Phe Tyr  Lys Met Phe Asp Ile  Arg Asn Trp 
    1220                 1225                 1230             


Val Ala  His Leu Asn His Ile  Gln Pro Gly Ser Thr  Thr Glu Arg 
    1235                 1240                 1245             


Ser Leu  Val Asp Ala Ile Asn  Asn Leu Arg Lys Leu  Leu Ser Tyr 
    1250                 1255                 1260             


Asp Arg  Lys Arg Lys Asn Ala  Val Thr Lys Ala Ile  Ile Glu Met 
    1265                 1270                 1275             


Met Glu  Lys Glu Lys Ile Gly  Leu Thr Phe Glu Ser  Asp Gly Gly 
    1280                 1285                 1290             


His Asp  Phe Lys Leu His Lys  Val Glu Ser Glu Gln  Ile Thr His 
    1295                 1300                 1305             


Leu Lys  Lys Val Ser Lys Lys  Phe Asp Ile Pro Ala  His Ser Lys 
    1310                 1315                 1320             


Glu Phe  Cys Glu Leu Val Gly  Gln Leu Phe Asn Trp  Lys Thr Lys 
    1325                 1330                 1335             


Glu Gln  Gln Gln Glu Gln Asn  Lys 
    1340                 1345     


<210>  730
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  730

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Thr Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Asp Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Ser Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val His Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1400                 1405                 1410         


<210>  731
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  731

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  732
<211>  1202
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  732

Met Lys Val Thr Lys Ile Asp Gly Ile Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Arg Phe Thr Gly Asn Phe Asn Ile Lys Asn Glu 
            20                  25                  30          


Met Lys Glu Arg Leu Glu Lys Leu Lys Glu Leu Lys Leu Ser Asn Tyr 
        35                  40                  45              


Ile Lys Asn Pro Glu Asn Val Lys Asn Lys Asp Lys Asn Lys Glu Lys 
    50                  55                  60                  


Glu Thr Lys Ser Arg Arg Glu Asn Leu Lys Lys Tyr Phe Ser Glu Ile 
65                  70                  75                  80  


Ile Leu Arg Lys Lys Glu Glu Lys Tyr Leu Leu Lys Lys Thr Arg Lys 
                85                  90                  95      


Phe Lys Asn Ile Thr Glu Glu Ile Asn Tyr Asp Asp Ile Lys Lys Arg 
            100                 105                 110         


Glu Asn Gln Gln Lys Ile Phe Asp Val Leu Lys Glu Leu Leu Glu Gln 
        115                 120                 125             


Arg Ile Asn Glu Asn Asp Lys Glu Glu Ile Leu Asn Phe Asp Ser Val 
    130                 135                 140                 


Lys Leu Lys Glu Ala Phe Gly Glu Asp Phe Ile Lys Lys Glu Ser Lys 
145                 150                 155                 160 


Ile Lys Ala Ile Glu Glu Ser Leu Glu Lys Asn Arg Ala Asp Tyr Arg 
                165                 170                 175     


Lys Gly Phe Val Glu Leu Glu Asn Gly Lys Tyr Glu Asp Val Lys Gly 
            180                 185                 190         


Gln Asn Lys Arg Ser Leu Val Phe Glu Tyr Tyr Lys Asn Pro Glu Asn 
        195                 200                 205             


Arg Glu Lys Phe Lys Glu Asn Ile Lys Tyr Ala Phe Glu Asn Leu Tyr 
    210                 215                 220                 


Thr Glu Glu Asn Ile Lys Asn Leu Tyr Ser Glu Ile Glu Glu Ile Phe 
225                 230                 235                 240 


Glu Lys Val His Leu Lys Ser Lys Val Arg Asn Phe Tyr Gln Asn Gly 
                245                 250                 255     


Ile Ile Gly Glu Ser Glu Phe Ser Glu Lys Asp Glu Glu Gly Ile Ser 
            260                 265                 270         


Ile Leu Tyr Lys Gln Ile Ile Asn Ser Val Glu Lys Lys Glu Lys Phe 
        275                 280                 285             


Val Glu Phe Leu Gln Lys Val Lys Ile Lys Asp Leu Thr Arg Ser Gln 
    290                 295                 300                 


Ile Phe Tyr Lys Tyr Phe Leu Glu Asn Glu Glu Leu Asn Asp Glu Asn 
305                 310                 315                 320 


Ile Lys Tyr Val Phe Ser Tyr Phe Val Glu Ile Glu Val Asn Lys Leu 
                325                 330                 335     


Leu Lys Glu Asn Val Tyr Lys Thr Lys Lys Phe Asn Glu Gly Asn Lys 
            340                 345                 350         


Tyr Arg Ile Lys Asn Ile Phe Asn Tyr Asp Lys Leu Lys Asn Leu Val 
        355                 360                 365             


Val Tyr Lys Leu Glu Asn Lys Leu Asn Asn Tyr Ile Arg Asn Cys Gly 
    370                 375                 380                 


Lys Tyr Asn Tyr His Met Glu Asn Gly Cys Val Ala Thr Ser Asp Thr 
385                 390                 395                 400 


Asn Met Lys Asn Arg Gln Thr Glu Ala Phe Leu Arg Ser Ile Leu Gly 
                405                 410                 415     


Val Ser Ser Phe Gly Tyr Phe Ser Leu Arg Asn Ile Leu Gly Val Asn 
            420                 425                 430         


Asp Asn Asp Phe Tyr Glu Met Glu Glu Glu Leu Thr Glu Asp Glu Arg 
        435                 440                 445             


Lys Asn Glu Asn Phe Ile Leu Lys Lys Ala Lys Glu Asp Ile Thr Ser 
    450                 455                 460                 


Lys Asn Ile Phe Glu Lys Val Val Asp Lys Ser Phe Glu Lys Lys Gly 
465                 470                 475                 480 


Ile Tyr Gln Ile Lys Glu Asn Leu Lys Met Phe Tyr Gly Asn Ser Phe 
                485                 490                 495     


Asp Lys Val Asp Lys Asp Glu Leu Lys Lys Phe Phe Val Asn Met Leu 
            500                 505                 510         


Glu Ala Ile Thr Ser Val Arg His Arg Ile Val His Tyr Asn Ile Asn 
        515                 520                 525             


Thr Asn Ser Glu Asn Ile Phe Asp Phe Ser Asn Ile Glu Val Ser Lys 
    530                 535                 540                 


Leu Leu Lys Asn Ile Phe Glu Lys Glu Ile Asp Thr Arg Glu Leu Lys 
545                 550                 555                 560 


Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Gly Val Phe Asp Tyr Trp 
                565                 570                 575     


Glu Ser Trp Val Ile Lys Lys Tyr Leu Glu Asn Val Lys Phe Glu Phe 
            580                 585                 590         


Val Asn Lys Asn Val Pro Phe Val Pro Ser Phe Lys Lys Leu Tyr Asp 
        595                 600                 605             


Arg Ile Asp Asn Leu Lys Gly Trp Asn Ala Leu Lys Leu Gly Asn Asn 
    610                 615                 620                 


Ile Asn Ile Pro Lys Arg Lys Glu Ala Lys Asp Ser Gln Ile Tyr Leu 
625                 630                 635                 640 


Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Val Glu Lys Phe Val Asn Asp 
                645                 650                 655     


Asn Lys Asn Phe Glu Lys Ile Val Lys Glu Ile Ile Glu Ile Asn Arg 
            660                 665                 670         


Gly Ala Gly Thr Asn Lys Arg Thr Gly Phe Tyr Lys Leu Glu Lys Phe 
        675                 680                 685             


Glu Thr Leu Lys Ala Asn Thr Pro Thr Glu Tyr Leu Glu Lys Leu Gln 
    690                 695                 700                 


Ser Leu His Lys Ile Ser Tyr Asp Lys Glu Lys Ile Glu Glu Asp Lys 
705                 710                 715                 720 


Asp Ile Tyr Val Asp Phe Val Gln Lys Ile Phe Leu Lys Gly Phe Val 
                725                 730                 735     


Asn Tyr Leu Lys Lys Leu Asp Ser Leu Lys Ser Leu Asn Leu Leu Asn 
            740                 745                 750         


Leu Arg Lys Asp Glu Thr Ile Thr Asp Lys Lys Ser Phe Tyr Asp Glu 
        755                 760                 765             


Lys Leu Lys Leu Trp Glu Asn Ser Gly Ser Asn Leu Ser Lys Met Pro 
    770                 775                 780                 


Glu Glu Ile Tyr Glu Tyr Val Lys Lys Ile Lys Ile Ser Asn Ile Asn 
785                 790                 795                 800 


Tyr Asn Asp Arg Met Ser Ile Phe Tyr Leu Leu Leu Lys Leu Ile Asp 
                805                 810                 815     


Tyr Arg Glu Leu Thr Asn Leu Arg Gly Asn Leu Glu Lys Tyr Glu Ser 
            820                 825                 830         


Met Asn Lys Asn Lys Ile Tyr Ser Glu Glu Leu Thr Ile Ile Asn Leu 
        835                 840                 845             


Val Asn Leu Asp Asn Asn Lys Val Arg Thr Asn Phe Ser Leu Glu Ala 
    850                 855                 860                 


Glu Asp Ile Gly Lys Phe Leu Lys Ser Ser Ile Lys Ile Lys Asn Ile 
865                 870                 875                 880 


Ala Gln Leu Asn Asn Phe Ser Lys Ile Phe Ala Asp Gly Glu Asn Val 
                885                 890                 895     


Ile Lys His Arg Ser Phe Tyr Asn Ile Lys Lys Tyr Gly Ile Leu Asp 
            900                 905                 910         


Leu Leu Glu Lys Ile Val Ala Lys Ala Asp Leu Lys Ile Thr Lys Glu 
        915                 920                 925             


Glu Ile Lys Lys Tyr Glu Asn Leu Gln Asn Glu Leu Lys Arg Asn Asp 
    930                 935                 940                 


Phe Tyr Lys Ile Gln Glu His Ile His Arg Asn Tyr Asn Gln Lys Pro 
945                 950                 955                 960 


Phe Leu Ile Lys Asn Asn Glu Lys Asp Phe Asn Asp Tyr Lys Lys Ala 
                965                 970                 975     


Ile Glu Asn Ile Gln Asn Tyr Thr Gln Leu Lys Asn Lys Ile Glu Phe 
            980                 985                 990         


Asn Asp Leu Asn Leu Leu Gln Ser  Leu Ile Phe Arg Ile  Leu His Arg 
        995                 1000                 1005             


Leu Ala  Gly Tyr Thr Ser Leu  Trp Glu Arg Asp Leu  Gln Phe Lys 
    1010                 1015                 1020             


Leu Lys  Gly Glu Tyr Pro Glu  Asp Lys Tyr Ile Asp  Glu Ile Phe 
    1025                 1030                 1035             


Asn Phe  Asp Asn Ser Lys Asn  Lys Ile Tyr Asn Glu  Lys Asn Lys 
    1040                 1045                 1050             


Arg Gly  Gly Ser Ile Val Ser  Lys Tyr Gly Tyr Phe  Leu Ala Glu 
    1055                 1060                 1065             


Lys Asp  Gly Glu Ile Gln Glu  Ser Arg Ala Arg Asp  Lys Lys Lys 
    1070                 1075                 1080             


Lys Lys  Ile Ile Lys Lys Glu  Gly Leu Glu Ile Arg  Asn Tyr Ile 
    1085                 1090                 1095             


Ala His  Phe Asn Tyr Ile Pro  Asp Ala Glu Lys Ser  Ile Leu Glu 
    1100                 1105                 1110             


Met Leu  Glu Glu Leu Arg Glu  Leu Leu Lys Tyr Asp  Arg Lys Leu 
    1115                 1120                 1125             


Lys Asn  Ala Val Met Lys Ser  Ile Lys Asp Ile Phe  Lys Glu Tyr 
    1130                 1135                 1140             


Gly Phe  Ile Val Glu Phe Ala  Ile Ser His Thr Lys  Asn Gly Lys 
    1145                 1150                 1155             


Lys Ile  Lys Val Cys Ser Val  Lys Ser Glu Lys Ile  Lys His Leu 
    1160                 1165                 1170             


Lys Asn  Asn Glu Leu Ile Thr  Thr Arg Asn Ser Glu  Asp Leu Cys 
    1175                 1180                 1185             


Glu Leu  Val Lys Ile Met Leu  Glu Tyr Lys Glu Leu  Gln Lys 
    1190                 1195                 1200         


<210>  733
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  733

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Lys Ile Pro Tyr Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Thr Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Lys Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Glu  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  734
<211>  1287
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  734

Met Arg Ile Gly Lys Val Gln Gly Arg Thr Phe Thr Gly Phe Asp Asn 
1               5                   10                  15      


Ala Arg Gly Lys Thr Leu Arg Arg Arg Leu Leu Thr Arg Pro Asp Asn 
            20                  25                  30          


Glu Ala Arg Ser Leu Ser Glu His Leu Ala His Asp Pro Lys Ala Leu 
        35                  40                  45              


Ile Gly Gln Ala Ile Ser Arg Ile Asp Thr Ile Tyr Gln Lys Pro Lys 
    50                  55                  60                  


Thr Gly Lys Pro Thr Pro Glu Gln Phe Gly His Arg Asp Thr Leu Gly 
65                  70                  75                  80  


Trp Ala Tyr Trp Lys Leu Leu Val Ala Ser Tyr Pro Glu Val Glu Gly 
                85                  90                  95      


His Arg Asp Leu Phe Val Arg Arg Leu His Pro Tyr Gly Asp Thr Pro 
            100                 105                 110         


Pro Lys Ser His Gly Gln Lys Glu Gly Glu His Gln Lys Gly Gly Lys 
        115                 120                 125             


Pro Gln Leu Glu Gly Arg Trp His Gly Val Met Ala Gln His Gly Lys 
    130                 135                 140                 


Asn Pro Asp Gln Ile Ala Ala Arg Leu Phe Asp His Leu His Asn Ser 
145                 150                 155                 160 


Glu Leu Arg Phe Gly Gly Thr Ala Ser Gly Glu Pro Arg Thr Arg Pro 
                165                 170                 175     


Gly Lys Glu Ala Thr Pro Thr Gly Leu Ile Gly Ala Arg Ala Lys Thr 
            180                 185                 190         


Ile Glu His Ser Val Leu Pro Arg Asp Ala Lys Arg Phe Val Ala Glu 
        195                 200                 205             


Trp Arg Gly Glu Asp Gln Glu Arg Tyr Ala Gly Ala Arg Asp Ile Ala 
    210                 215                 220                 


Ala Ala Ile Ser Ala Gly Leu Asn Asp Lys Asp Gln Lys Ser Gly Ser 
225                 230                 235                 240 


Gly Arg Lys Ser Ala Val Ile Gly Lys Leu Leu Ser Asp His Leu Glu 
                245                 250                 255     


Thr Leu Thr Gly Asn Arg Lys Cys Arg Phe Asp Pro Lys Ser Thr Ala 
            260                 265                 270         


Glu Thr Leu Glu Leu Arg Asp Gly Glu Ser Val Asp Asp Arg Arg Arg 
        275                 280                 285             


Ile Leu Glu Leu His Ala Glu Val Lys Ala Thr Tyr Lys Arg Met Ala 
    290                 295                 300                 


Ala Trp Lys Pro Ala Lys Leu Pro Arg Asn Ser Asp Glu Leu Phe Arg 
305                 310                 315                 320 


Leu Val Arg Gln Gln Ala Asp Asn Arg Ile Leu Asn His Leu Val Arg 
                325                 330                 335     


Val Gly Arg Ile Ser Val Tyr Ser Glu Gln Ser Asp Ala Leu Ser Glu 
            340                 345                 350         


Ser Gln Phe Trp Thr Ser Gly Gly Gln Thr Gln Ile Lys Glu Ser Glu 
        355                 360                 365             


Val Phe Ala Arg Leu Trp Ile Gly Ala Ile Ser Arg Ala Ser Tyr Ser 
    370                 375                 380                 


Met Lys Ala Trp Leu Glu Pro Glu Gly Thr Val Phe Asn Pro Ser Ile 
385                 390                 395                 400 


Asn Asp Phe Asp Val Thr Ser Ser His Asn Thr Asn Arg Ile Leu Glu 
                405                 410                 415     


Asp Ser Gly Arg Leu Ser Asn Ala Met Ala Arg Arg Ala Ile Tyr Phe 
            420                 425                 430         


Gly Glu Thr Pro Glu Phe Asp Ala Leu Gly Glu Glu Asp Gln Arg Val 
        435                 440                 445             


Leu Val Lys Lys Cys Leu Asp Ala Leu Ser Ala Cys Arg Asn Arg Thr 
    450                 455                 460                 


Phe His His Gly Gln Arg Ala Lys Phe Leu Lys Glu Val Arg Lys Gly 
465                 470                 475                 480 


Leu Lys Glu Lys Glu Ala Asp Ser Ala Gly Pro Ala Ala Trp Glu Gly 
                485                 490                 495     


Ile Arg Glu Val Ile Gln Ala Asp Ala Arg Asn Leu Gly Ala Arg Leu 
            500                 505                 510         


Leu Gln Asp Leu Thr Gly Ala Lys Val His Ser Phe Ala Thr Asp Pro 
        515                 520                 525             


Glu Phe Arg His Leu Tyr Glu Ser Val Ala Ala Thr Leu Thr Ala Gly 
    530                 535                 540                 


Gly Glu Leu Glu Ala Ala Leu Pro Arg Leu Lys Asn Val Leu Lys Arg 
545                 550                 555                 560 


Ala Glu Gly Val Arg Cys Tyr Leu Asp Thr Pro Ser Gln Arg Arg Glu 
                565                 570                 575     


Gly Asp Glu Ser Leu Ile Ala Arg Leu Pro Val Ala Pro Val Pro Arg 
            580                 585                 590         


Glu Leu Asp Asp Ala Ala Thr Lys Ala Arg His Ser Ala Leu Leu Arg 
        595                 600                 605             


Leu Tyr Asp Gly Pro Phe Arg Pro Trp Ala Thr Glu Leu Arg Gly Glu 
    610                 615                 620                 


Arg Leu Ser Asp Tyr Ala Ala Arg Ala Lys Arg Leu Ala Thr Arg Leu 
625                 630                 635                 640 


Ala Lys Ser Thr Asn Thr Ala Ser Pro Tyr Pro Asp Ser Val Glu Gly 
                645                 650                 655     


Arg Ser Val Arg Leu Arg Asp Pro Ile Thr Ala Asp Thr Ala Pro Glu 
            660                 665                 670         


Thr Leu Lys Thr Tyr Leu Ser Ala Leu Thr Ala Glu Thr Ala Thr Glu 
        675                 680                 685             


Phe Arg Val Gln Lys Gly Tyr Glu Ser Asp Gly Glu Lys Ala Lys Glu 
    690                 695                 700                 


Gln Ala Glu Phe Ile Glu Asp Phe Arg Arg Asp Met Ile Ala Leu Ala 
705                 710                 715                 720 


Phe Gln Asp Phe Ile Arg Asp His Gly Phe Ala Trp Leu Leu Asp Ile 
                725                 730                 735     


Ala Ser Lys Ala Glu Pro Ser Asn Asp Ala Pro Asn Leu Pro Asp Pro 
            740                 745                 750         


Val Asp Thr Gly Lys Asp Thr Val Phe Glu Asp Trp Gln Ala Leu Leu 
        755                 760                 765             


Tyr Leu Phe Leu His Phe Val Pro Ala Asp Asp Val Ser Gln Leu Leu 
    770                 775                 780                 


His Gln Leu Arg Lys Trp Asp Ala Leu Gln Asp Lys Tyr Glu Leu Ala 
785                 790                 795                 800 


Glu Pro Gly Glu Thr Leu Gly Gln Thr Lys Ala Asp Thr Arg Lys Ile 
                805                 810                 815     


Val Gly Gln Phe Arg Asp Cys Leu Thr Leu Phe Leu Lys Thr Gly Asp 
            820                 825                 830         


Ala Arg Phe Asp Gly Glu Gly Val Glu Leu Pro Leu Ser Asp Phe Gln 
        835                 840                 845             


Glu Leu Phe Glu Ser Pro Ala Thr Phe Lys Glu Leu Phe Leu Ala Glu 
    850                 855                 860                 


Pro Ala Glu Asn Asp Ala Ser Glu Thr Asp Asp Gln Asp Ala Pro Gly 
865                 870                 875                 880 


Glu Lys His Arg Val Thr Arg Thr Arg Arg Gly Leu Arg Gln Ile Leu 
                885                 890                 895     


Arg Tyr Asn His Met Pro Val Leu Arg Asp Leu Phe Leu Ala His Lys 
            900                 905                 910         


Val Thr Asp Ala Glu Val Asp Gly Leu Gln Ala Leu Glu Val Asp Asp 
        915                 920                 925             


Pro Gln Thr Gly Glu Ser Gln Ile Gly Ala Ala Gln Arg Ile Arg Thr 
    930                 935                 940                 


Glu Ile His His His Thr Ser Asn Asp Lys Gln Ile Ser Glu Ala Lys 
945                 950                 955                 960 


Val Glu Glu Tyr Arg Arg Ala Leu Ser Thr Ile Glu Arg His Arg Phe 
                965                 970                 975     


Leu Val Gly Arg Val Tyr Leu Gly Asp His Ile Arg Val His Lys Leu 
            980                 985                 990         


Met Met Asp Val Met Gly Arg Leu  Val Asp Phe Ala Gly  Ala Trp Glu 
        995                 1000                 1005             


Arg Glu  Ala Ala Asp Gly Asp  Arg Lys Gly Phe Ile  Ser Arg Ala 
    1010                 1015                 1020             


Ile Ala  Leu Pro Glu Val Ala  Glu Gly Tyr Ala Ala  Asp Arg Leu 
    1025                 1030                 1035             


Lys Thr  Val Ala Arg Arg Val  Leu Asp Asp Gly Glu  Ala Arg Arg 
    1040                 1045                 1050             


Ile Arg  Asn Asp Leu Gly His  Phe Asn Asp Leu Ala  Pro Thr Ser 
    1055                 1060                 1065             


Gly Pro  Ala Asn Leu Thr Phe  Val Val Asn Arg Ala  Arg Arg Met 
    1070                 1075                 1080             


Met Arg  His Asp Arg Lys Arg  Lys Asn Ala Val Thr  Lys Ser Val 
    1085                 1090                 1095             


Ile Glu  Ile Leu Asn Arg Gln  Gly Leu Gly Ile Glu  Trp Thr Met 
    1100                 1105                 1110             


Arg Asn  His Glu Leu Cys Glu  Ala Lys Leu Trp Gln  Asn Pro Val 
    1115                 1120                 1125             


Lys His  Leu Gly Phe Ala Thr  Leu Glu Gly Arg Gly  Lys Lys Trp 
    1130                 1135                 1140             


Arg Arg  Pro Phe Glu Ala Arg  Tyr Gly Asp Ala Tyr  Met Ala Met 
    1145                 1150                 1155             


Val Ala  Gln Leu Phe Asp Gly  Thr Val Thr Ser Pro  Pro Ala Lys 
    1160                 1165                 1170             


Gly Pro  Pro Gln Ser Gly Lys  Ser Gly Gly Lys Pro  Gly Lys Gly 
    1175                 1180                 1185             


Ala Glu  Gly Gly Ala Lys Glu  Lys Ser Arg Ser Pro  Thr Arg Met 
    1190                 1195                 1200             


Glu Glu  Gly Gly Val Tyr Glu  Gly Arg Val Ala Lys  Ala Lys Ser 
    1205                 1210                 1215             


Asp Lys  Gly Phe Gly Phe Leu  Leu Val Glu Gly Ala  Gln Glu Glu 
    1220                 1225                 1230             


Ile Phe  Leu His Ile Tyr Gly  Ile Ser Gly Asn Arg  Pro Ala Arg 
    1235                 1240                 1245             


Ile Glu  Asn Gly Gln Arg Tyr  Arg Phe Thr Leu Gly  Ile Asp Arg 
    1250                 1255                 1260             


Asp Arg  Glu Arg Arg Lys Glu  Arg Ala Trp Val Ala  Arg Glu Ala 
    1265                 1270                 1275             


Val Arg  Ile Asp Glu Asn Arg  Ser Lys 
    1280                 1285         


<210>  735
<211>  1373
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  735

Met Ala Lys His Leu Arg Pro Ile Gly Glu Ser Tyr Thr Asp Phe Leu 
1               5                   10                  15      


Asp Glu Thr Glu Phe Val Arg Leu Gly Arg Gly Leu His Arg Gly His 
            20                  25                  30          


His Gly Val Gln Ile Pro Pro Thr Glu Leu Pro Ser Tyr Leu Ala Glu 
        35                  40                  45              


Tyr Arg Lys Ala Leu Met Arg Gln Val Val Ala Val Leu Asp Lys Val 
    50                  55                  60                  


Val Gly Lys Arg Arg Arg Leu Ser Gly Met His Pro Glu Ala Tyr Arg 
65                  70                  75                  80  


Asp Arg Val His Leu Ala Glu Ala Leu Trp Val Arg Leu Val Ala Arg 
                85                  90                  95      


Val Lys Glu Ile Gly Thr Pro Pro Asp Pro Ser Glu Leu Leu Asp Leu 
            100                 105                 110         


Arg Arg Met Trp Asn Ala Lys Ala His Pro Tyr Ala Glu Tyr Asp Val 
        115                 120                 125             


Val Pro Arg Ala Pro Leu Asn Asp Gly Asn Gly Gln Lys Ile Leu Glu 
    130                 135                 140                 


Cys Arg Glu Val Asp Asp Pro Lys Ile Glu Arg Ser Asp Phe Glu Gly 
145                 150                 155                 160 


Arg Trp His Gly Arg Phe Trp Gln Ser Glu Pro Gly Pro Val Asp Tyr 
                165                 170                 175     


Asn Ala Ile Ala Asp Arg Ile Phe Ala His Leu Phe Asp Gln Glu Ala 
            180                 185                 190         


Val Ile Gly Gly Gly Pro Arg Arg Glu Gly Asn Val Thr Val Pro Asp 
        195                 200                 205             


Glu Asp Ile Asn Gly Gln Pro Gly Pro Ala Thr Gly Lys Gly Leu Ile 
    210                 215                 220                 


Ile Ala Arg Gly Gln Ser Ile Val Lys Ser Ala Ser Asp Pro Arg Arg 
225                 230                 235                 240 


Ser Ser Lys Lys Val Gln Arg Thr Trp Asp Lys Ala Val Glu Arg Arg 
                245                 250                 255     


Tyr Phe Gly Asp Asp Gly Lys Gly Gly Ser Asp Ile Ala Lys Ala Ile 
            260                 265                 270         


Tyr Glu Glu Leu Gly Asp Pro Ala Thr Leu Ala Asp Pro Ile Tyr Ala 
        275                 280                 285             


Ser Trp Phe Gly Ser Arg Leu Tyr Asp His Phe Gly Ser Phe Lys Asn 
    290                 295                 300                 


Ser Leu Pro Leu Glu Leu Lys Asp Pro Phe Lys Glu Gln Ile Trp Ala 
305                 310                 315                 320 


Leu His Asn Ser Val Arg Gln Phe Tyr Gln Arg Met Ala Lys Ser Asp 
                325                 330                 335     


Arg Phe Arg Leu Ala Leu Gln Asn Ala Arg Ser Glu Val Pro Asp Arg 
            340                 345                 350         


Ser Glu Leu Leu Ala Leu Leu Pro Lys Asp His Asp His Leu Leu Leu 
        355                 360                 365             


Val Leu Gly Gly Lys Lys Lys Asn Ala Glu Met Ser Glu Leu Ile Arg 
    370                 375                 380                 


Leu Gly Lys Leu Phe Val His Ala Ser Asp Val Leu His Asp Phe Asp 
385                 390                 395                 400 


Ala Asn Asp Ala Ala Ala Leu Asp Ala Phe Lys Arg Arg Met Ser Phe 
                405                 410                 415     


Leu Ala Thr Ser Ile Gly Gln Ser Glu Ile Lys Gln Thr Glu Thr Phe 
            420                 425                 430         


Ala Arg Thr Trp Arg Gly Ala Val Gly Leu Thr Leu Arg Thr Val Lys 
        435                 440                 445             


Gly Leu Ala Asp Pro Arg Gly Ile Ile Gly Thr Pro Asp Asn Arg Asp 
    450                 455                 460                 


Leu Gly Thr Ala Gly Pro Met Lys Asp Ala Phe Asn Lys Phe Asp Gln 
465                 470                 475                 480 


Pro His Phe Gln Gln His Met Thr Ile Ile Phe Gly Asn Lys Glu Leu 
                485                 490                 495     


Gln Ala Glu Gly Asn Pro Thr Arg Ser Ser Val Phe Thr Ala Asn Gly 
            500                 505                 510         


Asp Lys Asp His Gln Ala Glu Leu Leu Trp Gly Phe Leu Cys Val Val 
        515                 520                 525             


Arg Ser Val Arg Asn Arg Thr Asn His Tyr Asn Val Arg Arg Ala Leu 
    530                 535                 540                 


Leu Arg Leu Leu Asp Glu Gly Ile Val Ser Pro Met Pro Ser Asp Pro 
545                 550                 555                 560 


Lys Lys Glu Arg Val Glu Asn Arg Asn Leu Cys Thr Val Ser Pro Thr 
                565                 570                 575     


Ala Leu Glu Ala Phe Arg Arg Leu Leu Asn Phe Asp Leu Ala Ile Gln 
            580                 585                 590         


Lys Glu Ala Val Arg Thr Ala Leu Glu Gln Ala Lys Ala Ser Glu Phe 
        595                 600                 605             


Val Glu Glu Gly Lys Leu Arg Gly Leu Val Ser Glu Leu Ala Gly Thr 
    610                 615                 620                 


Glu Asp Met Pro Ala Leu His Ile Pro Arg Phe Ser Ala Val Met Asp 
625                 630                 635                 640 


Lys Val Arg Arg Leu Ala Asp Asn Arg Asp Val Gly Leu Asp Pro Ile 
                645                 650                 655     


Leu Ser Thr Leu Gln Arg Ser Leu Pro Pro Thr Asp Lys Gln Ala Glu 
            660                 665                 670         


Ser Asp Ala Ala Arg Cys Arg Tyr Arg Leu Leu Leu Glu Leu Tyr Lys 
        675                 680                 685             


Ser Gly Phe Arg Ser Trp Phe Ser Gly Ile Gln Ser Asn Glu Glu Asn 
    690                 695                 700                 


Asn Arg Glu Ile Cys His Trp Ala Val Lys Gln Val Gly Arg Ala Lys 
705                 710                 715                 720 


Asp Ala Arg Lys Ser Glu Tyr Asp Lys Lys Thr Lys Arg His Tyr Arg 
                725                 730                 735     


Ser Pro Asn Ser Leu Ile Asp Asp Leu Gly Leu Asp Lys Phe Asp Asp 
            740                 745                 750         


Leu Thr Asp Leu Leu Glu Ala Leu Ala Ser Gln Ser Thr Arg Glu His 
        755                 760                 765             


Asp Gln Asn Leu Lys Tyr Val Pro Asp Ala Arg Val Gln Ser Gln Met 
    770                 775                 780                 


Ser Asn Arg Ile Glu Glu Phe Arg Gln Glu Leu Phe Ala His Ile Phe 
785                 790                 795                 800 


Thr Lys Tyr Leu Asp Thr His Asp Phe Gly Trp Ile Gly Ala Ile Glu 
                805                 810                 815     


Val Arg Arg Glu Ala Cys Asp Leu Ala Asp Val Val Ser Ala Phe Glu 
            820                 825                 830         


Val Arg Asp Gln Lys Phe Asp Ala Asp Trp His Ser Gln Phe Tyr Ala 
        835                 840                 845             


Trp Leu Tyr Met Val Pro Pro Ile Glu Ala Ser Arg Leu Arg His Gln 
    850                 855                 860                 


Met Arg Lys Ser Ala Val Met Asp Asp Lys Trp Ser Thr Thr Leu Glu 
865                 870                 875                 880 


Leu Thr Ser Gly Asp Arg Lys Thr Arg Asp Asp His Ala Gln Asp Val 
                885                 890                 895     


Leu Ala Asp Met Asp Arg Leu Phe Ser Leu Tyr Thr Lys Val Gln Ala 
            900                 905                 910         


Ala Gly Phe Asn Gly Gln Glu His Glu Ser Ala Leu Gly Ser Lys Ser 
        915                 920                 925             


Leu Phe Tyr Glu Asp Gly Asn Gln Phe Asp Glu Val Tyr Ser Pro Asp 
    930                 935                 940                 


Thr Glu Thr His Asn Lys Thr Phe Pro Gly Thr Arg Arg Gly Leu Arg 
945                 950                 955                 960 


Gln Leu Val Arg Tyr Ala His Leu Pro Ala Leu Glu Gly Val Phe Lys 
                965                 970                 975     


Lys His Arg Ile Thr Lys Ala Glu Val Glu Thr Phe Val Ala Leu Tyr 
            980                 985                 990         


Asp Glu Asn Arg Arg Asp Pro Gly  Ser Val Ala His Met  Leu Arg Arg 
        995                 1000                 1005             


Glu Lys  Leu Arg Thr Glu Ile  Leu Arg Ser Ile His  Asp Gly Pro 
    1010                 1015                 1020             


Lys Pro  Lys Asp Lys Asp Phe  Trp Pro Lys Leu Glu  Ala Lys Cys 
    1025                 1030                 1035             


Leu Glu  Tyr Arg Thr Val Ala  Thr Glu Thr Ala Ile  Tyr Asn Phe 
    1040                 1045                 1050             


Gln Ala  Asn Ala Ala Arg Leu  Asn Asp His Ala Arg  Leu His Gln 
    1055                 1060                 1065             


Ile Val  Met Arg Val Val Ala  Arg Leu Thr Asp Tyr  Ala Leu Ile 
    1070                 1075                 1080             


Trp Glu  Arg Asp Arg Leu Phe  Ala Phe Val Gly Met  Leu Tyr Arg 
    1085                 1090                 1095             


Gln Thr  Gly Gly Thr Gly Ile  Asn Pro Ala Met Arg  His Ala Glu 
    1100                 1105                 1110             


Lys Thr  Asn Ala Pro Pro Arg  Ile Gly Ile Leu Val  Ser Asp Ser 
    1115                 1120                 1125             


Ala Leu  Ala Lys Lys Leu Asn  Ser Asn Ser Ala Glu  Val Phe Ile 
    1130                 1135                 1140             


Pro Tyr  Leu Asp Thr Glu Thr  Gly Phe Asp Ala Pro  Arg Phe Asp 
    1145                 1150                 1155             


Asp Leu  Cys Thr Leu Leu Ser  His Glu His Ala Lys  Glu Phe Arg 
    1160                 1165                 1170             


Phe His  Phe Leu Glu Val Gly  Glu Glu Asn Ser Lys  Asp Glu Ala 
    1175                 1180                 1185             


Arg Arg  Leu Asn Glu Glu Thr  Met Gly His Arg Lys  Arg Pro Ala 
    1190                 1195                 1200             


Phe Lys  Arg Gly Thr Arg Arg  Gln Gly Ile Arg Asn  Asp Leu Ala 
    1205                 1210                 1215             


His His  Asn Val Leu Asp Leu  Ala Gly Gly Ala Gly  Pro Asn Leu 
    1220                 1225                 1230             


Thr Tyr  Val Val Asn Ala Val  Arg Ser Leu Leu Ser  Tyr Asp Arg 
    1235                 1240                 1245             


Lys Leu  Lys Asn Ala Val Pro  Lys Ser Ile Lys Arg  Ile Leu Gly 
    1250                 1255                 1260             


Glu Glu  Gly Leu Ile Ile Glu  Trp Gln Met Asn Tyr  Asp Arg Leu 
    1265                 1270                 1275             


Lys Lys  Pro Thr Val Tyr Pro  Asn Val Glu Thr His  Leu Thr Met 
    1280                 1285                 1290             


Val Pro  Pro Arg His Met Thr  Ala Pro Val Ser Phe  Thr Leu Pro 
    1295                 1300                 1305             


Arg Ala  Ser Val Arg Leu Ala  Ser Met Val Lys Ala  Val Phe Asp 
    1310                 1315                 1320             


Phe Gly  Ser Ser Gly Tyr Gly  Glu Glu Arg Met Ile  Gly Gly Arg 
    1325                 1330                 1335             


Thr Ala  Lys Gln Ala Val Tyr  Pro Asp Asp Phe Thr  Arg Arg Phe 
    1340                 1345                 1350             


Pro Gln  Thr Pro Met Gly Leu  Lys Gln Ala Thr Arg  Leu Val Phe 
    1355                 1360                 1365             


Ala Ser  Glu Asn Ser 
    1370             


<210>  736
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  736

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Gly Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Glu 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Val Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Val 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Met 
    690                 695                 700                 


Tyr Ile Gly Asn Asp Glu Gln Ile Asn Thr Ser Leu Ala Gly Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Lys Ile Leu Lys Tyr Thr Glu Ser Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Val Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Tyr Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Leu Lys Glu Leu Lys Glu Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn Tyr Arg Met Gln Gln Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Lys Lys Asp Glu Lys Phe Asn Asp Glu Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Val Lys Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Lys Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Glu  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  737
<211>  1210
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  737

Met Lys Ile Thr Lys Arg Lys Trp Glu Asp Val Pro Pro Leu Phe Phe 
1               5                   10                  15      


His Arg Asp Lys Asp Ser Gly Arg Leu Ile Arg Gln Asp Asp Arg Glu 
            20                  25                  30          


His Asp Tyr Thr Asp Glu Leu Phe Arg Lys Thr Thr Val Asp Ser Ile 
        35                  40                  45              


Phe Ile Arg Ser Leu Gln Asn Arg Leu Leu Arg Ser Gln Asp Lys Glu 
    50                  55                  60                  


Gly Asn Lys Ile Gly Arg Asn Glu Ile Thr Glu Leu Val Glu Asn Leu 
65                  70                  75                  80  


Cys Lys Gly Ala Glu Ile Gln Lys Ser Ile Asp Glu Ile Lys Asp Ser 
                85                  90                  95      


Lys Ser Asn Val Lys Ala Leu Cys Asp Lys Thr Leu Thr Asp Tyr Gly 
            100                 105                 110         


Lys Ser Phe Ala Ala Glu Glu Gly Arg Thr Thr Leu Tyr Glu Ala Ile 
        115                 120                 125             


Leu Asn Leu Ala Lys Gly Asn Ala Ile Gln Lys Ala Met Ala Glu Ala 
    130                 135                 140                 


Glu Leu Lys Gln Ile His Glu Ala Leu Lys Lys Glu Lys Glu Asp Arg 
145                 150                 155                 160 


Ile Asn Arg Val Gln Asn Ser Ile Lys Asn Asn Lys Ile Pro Leu Lys 
                165                 170                 175     


Val Asn Glu Asp Gly Thr Ile Ser Ala Asn Asn Asp Arg Ala Ser Trp 
            180                 185                 190         


Leu Leu Glu Leu Leu Lys Pro Val Ala Ser Glu His Asp Lys Gly Asp 
        195                 200                 205             


Arg Tyr Pro Val Leu Thr Glu Met Glu Gly Ile Val Ser Phe Asp Lys 
    210                 215                 220                 


Leu Cys Glu Glu Val Arg Asn Lys Ile His Gly Arg Lys Gly Arg Thr 
225                 230                 235                 240 


Arg Ser Ile Ala Met Ser Val Asp Glu Ala Val Lys Glu Tyr Leu Lys 
                245                 250                 255     


Glu Leu Trp Lys Lys His Ala Asp Arg His Arg Asp Met Arg Tyr Tyr 
            260                 265                 270         


Phe Gln Ala Val Lys Glu Tyr Phe Lys Glu Asn Phe Pro Ile Arg Thr 
        275                 280                 285             


Lys Gln Lys Gly Ala Gly Ile Arg Gln Ser Leu Leu Lys Glu Asp Thr 
    290                 295                 300                 


Val Val Ala Arg Leu Leu Asp Pro Lys His Met Ala Lys Ala Val Arg 
305                 310                 315                 320 


Arg Lys Leu Ile Asn Gln Ser Ile Gln Met His Ile Leu Tyr Gly Lys 
                325                 330                 335     


Leu Tyr Glu Tyr Cys Cys Arg Glu Asp Arg Asn Leu Pro Val Asn Ser 
            340                 345                 350         


Glu Thr Leu Gln Leu Ile Gln Val Leu Glu Ala Phe Lys Lys Gln Leu 
        355                 360                 365             


Met Thr Ala Val Leu Trp Ser Val Ser Arg Leu Cys Tyr Phe Tyr Glu 
    370                 375                 380                 


Phe Tyr Ser Gly Asp Ile Leu Leu Ala Glu Glu Tyr Arg Arg Asp Phe 
385                 390                 395                 400 


Leu Asn Gln Lys Asn Asp His Lys Asp Ile Gln Ala Cys Lys Glu Lys 
                405                 410                 415     


Leu Gln Asp Phe Phe Pro Leu Ala Glu Leu Gln Glu Lys Ile Arg Glu 
            420                 425                 430         


Cys Ala Asp Lys Asp Ile Asn Asn Ile Lys Asp Lys Ile Thr Asn Asp 
        435                 440                 445             


Val Leu Ala Cys Asn Asn Leu Leu Glu Glu Cys Val Phe Cys Ile Ser 
    450                 455                 460                 


Lys Leu Arg Asn Asn Ile Phe His Tyr Lys Asn Leu Ser Phe Thr Gln 
465                 470                 475                 480 


Ala Leu Lys His Ile Ala Asn Glu Ile Lys Glu Glu Asp Ile Pro Ile 
                485                 490                 495     


Ile Leu Arg Leu Tyr Lys Gln Asp Cys Glu Asn Val Asn Lys Ala Phe 
            500                 505                 510         


Ala Asn Arg Ile Ser Ser Met Asn Leu Pro Leu Tyr Tyr Ser Thr Glu 
        515                 520                 525             


Phe Leu Leu Arg Ile Phe Lys Lys Gln Gly Ala Glu Leu Ser Leu Tyr 
    530                 535                 540                 


Ser Thr Lys Asn Gln Met Thr Pro Ser Phe Lys Arg Val Tyr Glu Arg 
545                 550                 555                 560 


Gly Lys Asn Leu Arg Leu Glu Tyr Glu Arg Glu Pro Met Arg Ser Asn 
                565                 570                 575     


Ile Ala Asn Glu Tyr Asp Lys Asp Pro Gln Ser Asp Tyr Trp Met Arg 
            580                 585                 590         


Trp Phe Ser Gln Phe Ala Thr Gly Thr Val Asp Thr Asn Ala Gly Ile 
        595                 600                 605             


Lys Gly Glu Met Glu Asp Tyr Pro His Ala Ser Val Asn Leu Gly Ile 
    610                 615                 620                 


Glu Ile Glu Ala Gly Thr Asn Ile Asp Ala Gln Arg Ala Met Arg Asn 
625                 630                 635                 640 


Leu Leu Gln Leu Ile Tyr Lys His His Phe Leu Pro Glu Val Gln Lys 
                645                 650                 655     


Asp Glu Thr Val Val Thr Asp Val Ile Pro Lys Val Leu Glu Arg Asn 
            660                 665                 670         


Arg Lys Leu Ser Glu Val Arg Asn Arg Ser Asp Lys Thr Tyr Gly Tyr 
        675                 680                 685             


Lys Glu Ile Glu Glu Leu Cys Lys Lys Asn Lys Gly Lys Lys Asp Ser 
    690                 695                 700                 


Leu Ser Glu Leu Met Lys Asp Leu Gln Arg Lys Val Ser Glu Thr Glu 
705                 710                 715                 720 


Lys Glu Lys Arg Glu Leu Ala Arg Glu Lys Thr Asp Tyr Ala Gln Arg 
                725                 730                 735     


Phe Ile Leu Asp Ile Phe Ala Glu Ala Phe Cys Asn Phe Met Asp Glu 
            740                 745                 750         


Arg Tyr Glu Asp Glu Tyr Gln Glu Ile Met Ser Pro Ile Lys Asn Glu 
        755                 760                 765             


Glu Glu Ala Lys Lys Trp Thr Glu Met Phe Thr Asp Lys Ala Asp Lys 
    770                 775                 780                 


Asp Asn Lys Asp Lys Leu Leu Val Leu Lys Thr Ser Phe Asp Lys Asp 
785                 790                 795                 800 


Asn Val Glu Lys Tyr Leu Leu Ala Leu Tyr Pro Leu Met Arg Leu Leu 
                805                 810                 815     


Asp Asp Lys Glu Leu Ser Glu Leu Gln Gln Gln Met Leu Arg Phe Arg 
            820                 825                 830         


Ala Ser Val Ser Gly Trp Gln Gly Gly Thr Asp Phe Ser Glu Asp Ile 
        835                 840                 845             


Ala Met Ala Glu Lys Ile Glu Glu Leu Ala Glu Leu Val Lys Leu Thr 
    850                 855                 860                 


Glu Pro Glu Ser Gln Tyr Ala Glu Glu Ala Trp Lys Asn Arg Ala Ile 
865                 870                 875                 880 


Gly Val Phe Glu Gln Phe Val Glu Gly Lys Met Ala Glu Tyr Gly Thr 
                885                 890                 895     


Phe Tyr Ile Gln Asn Asp Ser Leu Thr Gln Val Pro Arg Gly Asn Met 
            900                 905                 910         


Arg Lys Leu Leu Arg Ser Gly Val Ile Gly Val Tyr Asn Lys Val Leu 
        915                 920                 925             


Ala Ser Cys Lys Gln Ala Thr Lys Ala Asp Tyr Gly Ala Tyr Ser Gly 
    930                 935                 940                 


Asp His Trp Ser Ile Glu Asp Pro Asp Gly Asn Pro Ile Lys Ser Ala 
945                 950                 955                 960 


Glu Gln Ala Gln Ala Leu Leu Gln Arg Leu His Lys Lys Tyr Thr Glu 
                965                 970                 975     


Ser Pro Ser Gln Phe Ser Asp Asp Asp His Lys Leu Tyr Asp Lys Thr 
            980                 985                 990         


Leu Arg Gln Leu Asp Ala Tyr Asn  Arg Ala Met Lys Asn  Leu Ser Phe 
        995                 1000                 1005             


Gly Ser  Leu Tyr Glu Ile Cys  Arg Ile His Met Glu  Thr Leu Ser 
    1010                 1015                 1020             


Arg Trp  Val Gly Phe Val Gln  Asp Trp Glu Arg Asp  Met Tyr Phe 
    1025                 1030                 1035             


Leu Leu  Leu Ala Trp Thr Lys  Gln Gly Lys Leu Leu  Asn Val Thr 
    1040                 1045                 1050             


Glu Thr  Asp Val Ile Glu Ile  Phe Glu Lys Gly Ser  Val Ile Tyr 
    1055                 1060                 1065             


Lys Met  Asn Lys Lys Leu Lys  Asn Gly Asp Arg Tyr  Ala Phe Thr 
    1070                 1075                 1080             


Ser Ile  Tyr Arg Asn Asn Asn  Asp Glu Lys Leu Glu  Phe Leu Gln 
    1085                 1090                 1095             


Ile Arg  Asn Phe Ile Ala His  Leu His Leu Leu Arg  Lys Ser Glu 
    1100                 1105                 1110             


Trp Lys  Gly Asp Lys Lys Ala  Gly Tyr Ser Val Ile  Glu Asp Tyr 
    1115                 1120                 1125             


Ile Asn  Lys Leu Arg Phe Leu  Leu Ser Tyr Asp Gln  Lys Arg Met 
    1130                 1135                 1140             


Asn Ala  Val Thr Lys Ala Met  Gln Gln Ile Phe Glu  Lys His Lys 
    1145                 1150                 1155             


Val Ile  Val Lys Phe Met Val  Glu Lys Gly Gly Met  Leu Lys Val 
    1160                 1165                 1170             


Lys Asp  Val Lys Pro Gly Ile  Ile Glu His Leu Lys  Gln Thr Lys 
    1175                 1180                 1185             


Arg Ile  Glu Ile Pro Cys His  Gly Glu Arg Phe Thr  Asp Ser Leu 
    1190                 1195                 1200             


Leu Val  Leu Met Lys Tyr Gln  
    1205                 1210 


<210>  738
<211>  1208
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  738

Met Gln Ile Ile Lys Pro Tyr Gly Arg Ser Phe Thr Glu Thr Asn Gln 
1               5                   10                  15      


Arg Val Leu Leu Asp Lys His Arg Asp Lys His Asp Ile Ser Pro Phe 
            20                  25                  30          


Ala Ala Ser His Glu Lys Leu Val Ile Ala Gln Trp Val Ser Val Ile 
        35                  40                  45              


Asp Lys Ile Val Arg Lys Pro Asn Pro Lys Ala Lys Ile Ser Leu Pro 
    50                  55                  60                  


Thr Pro Gln Gln Tyr Gln Leu Arg Glu Thr Leu Gly Asn Ala Ala Trp 
65                  70                  75                  80  


Leu Glu Leu Asn Lys Arg Leu Pro Cys Ser Asp His Ala Val Phe Trp 
                85                  90                  95      


Arg Ser Lys Ile His Pro Tyr Gly His Ala Thr Gln Glu Gln Glu Pro 
            100                 105                 110         


Ala Pro Leu Leu Gln Gly Arg Trp Tyr Gln Arg Phe Val Gly Asp Ile 
        115                 120                 125             


Glu Pro Thr Ala Ile Thr Glu Asn Val Ala Gln Ile Ile Ala Glu Arg 
    130                 135                 140                 


Ile Ala Ser His Leu Tyr Glu Ala Glu Leu Arg Leu Ser Pro Glu Ala 
145                 150                 155                 160 


Glu Pro Arg Gly Lys Gly Lys Ile Gln Ala Gln Ala Glu Ser Ile Glu 
                165                 170                 175     


Lys Asn Thr Leu His Gln Pro Lys Leu Ser Ala Thr Trp Cys Asp Ala 
            180                 185                 190         


Asp Trp Thr Ala Tyr Asn Arg His Asp Val Ala Glu Arg Ile Tyr Leu 
        195                 200                 205             


Glu Ala Lys Phe Arg Leu Glu Gln Lys Gln Glu Ala Arg Lys Asn Lys 
    210                 215                 220                 


Gln Pro Met Gln Leu Glu Trp Arg Ile Asp Arg Ser Leu Thr Gly Lys 
225                 230                 235                 240 


Ile Leu Phe Glu His Trp Ala Lys Val Tyr Ser Gly Thr Asp Gly Lys 
                245                 250                 255     


Ser Arg Ile Thr Glu Ala Lys Gln Glu Lys Pro Gly Leu Phe His Leu 
            260                 265                 270         


His Met Ala Val Lys Asp Phe Tyr Thr Arg Leu Phe Asp Arg Asp Arg 
        275                 280                 285             


Arg Asp Glu Thr Leu Val Glu Phe Leu Leu Pro Arg Lys Lys Lys Ala 
    290                 295                 300                 


Leu Arg Glu Lys Leu Glu Gln Lys Ser Lys Asn Thr Asp Leu Ala Ala 
305                 310                 315                 320 


Ser Ile Arg Leu Gly Lys Ile Leu Tyr Tyr Arg Glu Ala Glu Ser Glu 
                325                 330                 335     


Thr Val Pro Leu Ala Asn Ser Arg Phe Trp Gly Ser Glu Gly Gln Ala 
            340                 345                 350         


Glu Ile Lys Arg Ala Glu Ala Phe Val Arg Val Trp Arg His Val Leu 
        355                 360                 365             


Gly Gln Ser Asn Leu Thr Leu Ala Asn Trp Ala Ser Leu Ala Ser Pro 
    370                 375                 380                 


Asp Glu Leu Trp Glu Lys Asp Ser Phe Asp Ser Lys Phe Leu Asp His 
385                 390                 395                 400 


Val Glu Lys Leu Phe Ala Lys Asp Asn Gly Leu Asp Lys Arg Arg Gln 
                405                 410                 415     


Glu Phe Asp Gln Asn Leu Asn Leu Leu Leu Gly Asp Gly Ala Ser Ala 
            420                 425                 430         


Phe Met Ala Asp Asp Asp Ser Arg Gln Ala Ala Ile Arg Leu Ala Tyr 
        435                 440                 445             


Asp Val Gly Ser Ala Leu Arg His Ala Ala Phe His Phe Lys Gly Arg 
    450                 455                 460                 


Asp Lys Phe Leu Glu Val Leu Asp Lys Asp Leu Ser Asp Lys Gly Gln 
465                 470                 475                 480 


Ala Ser Gly Leu Leu Leu Pro Leu Asn Lys Leu Leu Ala Thr Ala Gln 
                485                 490                 495     


Glu Lys Gln Asp Glu Arg Leu Leu Ala Thr Leu Glu Gly Ala His Val 
            500                 505                 510         


Phe Gln Val Cys Thr Gln Ala Gln Val Gln Gln Leu Val Asn Ser Ile 
        515                 520                 525             


Cys Ala Ile Pro Thr Gly Asp Leu Pro Leu Pro Arg Phe Gly Arg Val 
    530                 535                 540                 


Ile Glu Arg Asn His Asn Ala Gly Leu Lys Thr Gly Leu Pro Ser Arg 
545                 550                 555                 560 


Val Asn Arg Gln Ala Met Glu Gln Asn Pro Ala Gln Lys Cys Gln Tyr 
                565                 570                 575     


Val Val Leu Lys Met Leu Tyr Glu Arg Pro Phe Arg Val Trp Leu Glu 
            580                 585                 590         


Gly Ala Thr Asp Ala Met Leu Ser Thr Trp Leu Thr Thr Ala Leu Asn 
        595                 600                 605             


Arg Ser Thr Thr Ala Ala Arg Asn Asn Pro Asp Val Ser Arg Lys Pro 
    610                 615                 620                 


Gln Asp Glu Arg Glu Leu Val Thr Ser Arg Ala Ala Lys Leu Pro Ile 
625                 630                 635                 640 


Ala Ile Gly Gly Lys Asp Gly Gln Gly Lys Asn Lys Ser Ile Arg Gln 
                645                 650                 655     


Phe Phe His Asp Leu Ser Ala Ala Thr Ala Ser Glu Met Arg Val Gln 
            660                 665                 670         


Arg Gly Tyr Ala Ser Asp Ala Glu Lys Ala Arg Glu Gln Ala Glu Tyr 
        675                 680                 685             


Ile Asp Glu Leu Leu Arg Asp Val Val Ala Leu Ala Phe Lys Asp Phe 
    690                 695                 700                 


Leu Asp Gly Lys Gly Leu Cys Trp Leu Leu Asp Ile Asp Pro Lys Gln 
705                 710                 715                 720 


Ala Leu Gln Pro Ile Arg Cys Cys Pro Thr Glu Asn Ile Gln Leu Pro 
                725                 730                 735     


Ala Ser Thr Leu Gln Ile Val Asn Trp Gln Pro Val Leu Tyr Phe Leu 
            740                 745                 750         


Leu His Leu Met Pro Val Gly Glu Val Ser Gln Leu Leu His Gln Leu 
        755                 760                 765             


Ala Lys Trp Glu Ile Leu Ala Lys Pro Glu Gln Ala Arg Asn Asp Thr 
    770                 775                 780                 


Glu Gly Ile Arg Ile Lys Ala Leu Gln His Thr Leu Lys Leu Tyr Leu 
785                 790                 795                 800 


Asp Met His Asp Ser Gln Tyr Thr Gly Asp Asp Ala Met Pro Thr Val 
                805                 810                 815     


Glu Arg Asp Val Leu Thr Thr Phe Ser Ser Phe Tyr Glu Asn Pro Arg 
            820                 825                 830         


Val Phe Ala Gln Val Phe Glu Asn Gln Gly Asn Gly Arg Glu Arg Ala 
        835                 840                 845             


Gln Tyr Leu Pro Gln Arg Gly Leu Arg Glu Ile Arg Arg Phe Gly His 
    850                 855                 860                 


Thr Pro Val Leu Gln Thr Leu Val Lys Lys Lys Ile Thr Ala Glu Asp 
865                 870                 875                 880 


Val Ser Arg Cys Leu Thr Ala Glu Ala Pro Leu Lys Asn Gly Ile Tyr 
                885                 890                 895     


Ser Val Val Ala Glu Ala Gln Ser Gln Arg Glu Ala Leu His Ala Gln 
            900                 905                 910         


Trp Val Lys Glu Arg Lys Gln Phe Glu Trp Tyr Gln Asp Tyr Ala Ala 
        915                 920                 925             


Ala Leu Lys Lys Val Val Ala His Arg Gln Asp Ser Asn His Ile Arg 
    930                 935                 940                 


Leu Val Asp His Val Ala Ala His Arg Ile Val Met Lys Val Leu Ala 
945                 950                 955                 960 


Arg Leu Ala Asp Phe Ser Gly Leu Phe Glu Arg Asp Leu Thr Phe Val 
                965                 970                 975     


Thr Leu Ala Thr Leu His Glu His Gln Leu Lys Pro Glu Asp Phe Phe 
            980                 985                 990         


Val Thr Asp Asn Pro Pro Lys Tyr  Asn Lys Lys Gly Lys  Met Glu Asp 
        995                 1000                 1005             


Asp Gly  Leu Thr Leu Phe Lys  Lys Gly Gln Ile Ile  Glu Ala Met 
    1010                 1015                 1020             


Gly Lys  Val Gln Val Ser Arg  Asn Ala Val Lys Gln  Ala Ile Val 
    1025                 1030                 1035             


Gly Arg  Val Asn Leu Asp Leu  Tyr Arg Ser Ile Arg  Asn Asp Phe 
    1040                 1045                 1050             


Ala His  Phe Asn Met Leu Tyr  Gly Lys Gln Arg Thr  Thr Glu Ser 
    1055                 1060                 1065             


Pro Ser  Asn Lys Met Leu Arg  Cys Ser Val Ala Met  Gly Leu Asn 
    1070                 1075                 1080             


Val Thr  Cys Trp Val Asn Cys  Ala Arg Asp Leu Met  Ser Tyr Asp 
    1085                 1090                 1095             


Arg Lys  Leu Lys Asn Ala Val  Ser Gln Ser Ile Met  Glu Leu Leu 
    1100                 1105                 1110             


Glu Arg  Glu Gly Phe Ile Leu  Thr Trp Glu Met Asn  Ser His His 
    1115                 1120                 1125             


Gln Leu  Cys Asn Ala Thr Leu  Glu Ser Arg Val Val  His His Leu 
    1130                 1135                 1140             


Gly Asp  Lys Lys Phe Pro Leu  Lys Glu Asp Lys Arg  Ala Phe Cys 
    1145                 1150                 1155             


Arg Ile  Thr Glu Ser Leu His  Ser Asp Ala Phe Val  Arg Met Leu 
    1160                 1165                 1170             


Ala Val  Ala Phe Gly Gly Ala  Ala His Pro Asn Gln  Asp Ile Gly 
    1175                 1180                 1185             


Thr Leu  Asp Leu Gln Thr Val  Asn Trp Glu Gly Ala  Lys Ala Lys 
    1190                 1195                 1200             


Trp Ala  Gly Ser Gln 
    1205             


<210>  739
<211>  1268
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  739

Met Lys Val Ser Lys Val Asn His Arg Arg Ala Ala Val Ala Val Asn 
1               5                   10                  15      


Lys Lys Ser Val Thr Val Asn Gly Ile Leu Tyr Asp Ala Pro Val Lys 
            20                  25                  30          


Lys Asn Val Lys Thr Gly Asn Met Ser Ala Tyr Val Ser Ser Lys Tyr 
        35                  40                  45              


Val Ile Asp Asn Val Val Lys Asn Ser Ser Arg Leu Tyr Ser Pro Phe 
    50                  55                  60                  


Ser Ser Lys Arg Ile Val Ile Asp Arg Glu Lys Ile Arg Ile Ala Asp 
65                  70                  75                  80  


Arg Leu Lys Gln Cys Tyr Val Asn Phe Val Lys Tyr Tyr Leu Ser Asn 
                85                  90                  95      


Gly Ser Leu Asn Glu Gln Gln Met Arg Phe Asn Pro Asn Asn Thr Tyr 
            100                 105                 110         


Met Ala Asp Ser Arg Val His Phe Cys Val Pro Ser Gly Ile Asp Ile 
        115                 120                 125             


Glu Ser Leu Ile Asn Ser Ile Val Asp Ser Ser Leu Arg Lys Ser Leu 
    130                 135                 140                 


Lys Arg Thr Tyr Arg Phe Glu Thr Asn Tyr Gly Glu Lys Asn Thr Phe 
145                 150                 155                 160 


Asn Leu Pro Asp Leu Val Lys Lys Ser Ile Lys Ile Tyr Cys Thr Asp 
                165                 170                 175     


Glu Lys Arg Lys Leu Asn Asp Arg Glu Glu Gln Glu Met Tyr Val Leu 
            180                 185                 190         


Phe Ser Tyr Met Tyr Glu Asp Lys Tyr Lys Asp Arg Gln Lys Val Leu 
        195                 200                 205             


Ile Ala Asn Ser Ile Ser Asn Gln Ala Thr Lys Val Lys Val Cys Asp 
    210                 215                 220                 


Asp Glu Ser Arg Leu Ile Lys Leu Ser Ile Ala Asp Thr Lys Lys Lys 
225                 230                 235                 240 


Pro Leu Trp Asp Phe Ile Val Asp Tyr Ala Asn Ser Asp Lys Asn Gly 
                245                 250                 255     


Gln Tyr Thr Ile Leu Arg Asn Ile Arg Lys Ser Ile Val Leu Phe Val 
            260                 265                 270         


Cys Gly Val Asp Val Tyr Arg Asn Ile Glu Asn Asn Asp Asn Leu Asp 
        275                 280                 285             


Ile Trp Lys Trp Glu Glu Tyr Gly Ile Gln Glu Ser Gln Leu Phe Val 
    290                 295                 300                 


Lys Ile Glu Asn Cys Tyr Thr Thr Lys Gly Glu Asp Ile Ala Leu Asn 
305                 310                 315                 320 


Glu Ile Arg Asn Val Asn Leu Asp His Tyr Met Lys Ala Ile Gly Val 
                325                 330                 335     


Leu Asp Asp Glu Arg Ser Lys Phe Trp Phe Gln His Tyr Glu Asn Thr 
            340                 345                 350         


Ile Glu Ala Leu Phe Ser Lys Lys Ser Lys Arg Lys Ile Glu Arg Ile 
        355                 360                 365             


Lys Thr Ala Tyr Leu Cys Glu Tyr Leu Trp Lys Asn Phe Cys Ser Tyr 
    370                 375                 380                 


Val Ala Leu Lys Tyr Val Asp Leu Gly Lys Gly Val Tyr His Phe Thr 
385                 390                 395                 400 


Met Ser Asp Lys Leu Ser Leu Met Asn Lys Asn Thr Asn Glu Asn Gly 
                405                 410                 415     


Ile Lys Phe Gly Glu Val Asp Ser Arg Phe Asn Lys Gly Ile Ser Ser 
            420                 425                 430         


Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Thr Ile Asp Arg Asn Ile 
        435                 440                 445             


Ser Thr Tyr Thr Thr Phe Ala Thr Asn Ile Phe Ala Lys Ser Val Ile 
    450                 455                 460                 


Lys Asp Ser Tyr Arg Gln Lys Lys Ala Gly Asn Ser Asp Ala Leu Gln 
465                 470                 475                 480 


Tyr Asp Asp Glu Thr Tyr Tyr Asn Arg Lys Ala Met Asn Pro Tyr Ala 
                485                 490                 495     


Leu Lys Arg Val Leu Arg Tyr Trp Gly Gly Gln Ser Arg Trp Lys Ser 
            500                 505                 510         


Glu Leu Glu Glu Leu Asn Val Ala Glu Leu Cys Ile Asp Ile Lys Asn 
        515                 520                 525             


Arg Leu Ser Lys Ile Arg Asn Ser Gly Val His Tyr Thr Ser Thr Ser 
    530                 535                 540                 


Ala Leu Lys Gly Asn Asp Asp Asp Ser Ile Val Gly Met Leu Ile Lys 
545                 550                 555                 560 


Lys Asp Phe Asp Asp Ile Lys Asp Val Tyr Ala Ser Lys Tyr Tyr Ser 
                565                 570                 575     


Asn Asn Val Trp Met Phe Tyr Asn Thr Asp Lys Ile Ser Lys Met Met 
            580                 585                 590         


Glu Tyr Leu Tyr Gln Asp Asp Ser Asn Ile Arg Asp Ala Gln Ile Pro 
        595                 600                 605             


Ala Phe Asn Ser Val Ile Lys Arg Lys Asp Met Ala Glu Val Ile Glu 
    610                 615                 620                 


Lys Ile Val Lys Lys Asn Ser Tyr Lys Thr Ile Lys Glu Leu Tyr Gln 
625                 630                 635                 640 


Arg Glu Lys Tyr Arg Ser Cys Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
                645                 650                 655     


Tyr Asn Arg Phe Ile Lys Gln Asp Asn Leu Lys Asp Gln Val Ile Gln 
            660                 665                 670         


Ile Ile Asp Ser Asn Thr Glu Leu Ile Gly Asp Asn Ser Arg Ala Val 
        675                 680                 685             


Asp Asn Leu Lys Lys Arg Ile His Asp Val Asp Ser Gln Thr Met Ser 
    690                 695                 700                 


Phe Gly Glu Leu Cys Gln Val Ile Met Thr Asp Tyr Asn Met Gln Asn 
705                 710                 715                 720 


Gln Glu Asn Lys Ser Ile Lys Ser Lys Glu Arg Gln Asp Lys Asp Arg 
                725                 730                 735     


Lys Asn Gly Ile Asp Asn Ser Tyr Lys His Phe Pro Leu Leu Leu His 
            740                 745                 750         


His Leu Ile Lys Val Ser Phe Leu Lys Phe Ile Lys Thr Asp Glu Lys 
        755                 760                 765             


Leu Ala Phe Ile Arg Glu Pro Arg Ile Thr Glu Leu Asp Lys Thr Leu 
    770                 775                 780                 


Glu Gln Phe Glu Ala Gln Ile Gln Thr Val Asp Ile Tyr Asn Ser Leu 
785                 790                 795                 800 


Lys Met Met Val Ala Glu Asn Lys Ser Leu Leu Asp Trp Tyr Thr Leu 
                805                 810                 815     


Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asp Val 
            820                 825                 830         


Lys Asn Tyr Ile Gln Tyr Leu Ser Asn Ile Asp Lys Arg Ala Gly Ser 
        835                 840                 845             


Val Lys Asn Asn Lys Ser Ala Ser Thr Glu Val Lys Ile Arg Gln Tyr 
    850                 855                 860                 


Ser Glu Ile Val Arg Ile Leu Asp Phe Ser Leu Gln Tyr Ile Gly Arg 
865                 870                 875                 880 


Val Ser Asn Asp Val Thr Asp Tyr Phe Val Asp Glu Asp Glu Tyr Ala 
                885                 890                 895     


Ala Phe Leu Ser Lys Tyr Val Glu Phe Ser Gly Asn Asp Ile Val Ser 
            900                 905                 910         


Met Lys Ala Phe Cys Gln Ser Arg Thr Ala Asn Gly Lys His Thr Ile 
        915                 920                 925             


Gly Leu Tyr Cys Asp Gly Ala Asn Pro Ile Met Asn Arg Asn Ile Ala 
    930                 935                 940                 


Tyr Ala Lys Met Tyr Gly Asn Asp Glu Ile Leu Ser Tyr Ile Tyr Asn 
945                 950                 955                 960 


Lys Val Thr Lys Lys Asp Ile Glu Lys Tyr Tyr Val Ser Gln Asp Asn 
                965                 970                 975     


Leu Glu Lys Val Phe Ala Asp Gly Lys Cys Gln Asp Val Gln Gln Gln 
            980                 985                 990         


Asn Ala Leu Cys Asp Phe Gln Lys  Met Lys Asn His Ile  Glu Leu Thr 
        995                 1000                 1005             


Glu Gly  Ser Ile Tyr Thr Asp  Ile Leu Asn Asp Phe  Met Ala Gln 
    1010                 1015                 1020             


Phe Ile  Ser Trp Ala Tyr Leu  Arg Glu Arg Asp Leu  Met Tyr Phe 
    1025                 1030                 1035             


Gln Leu  Gly Leu Asn Tyr Ile  Arg Met Phe Tyr Gly  Thr Tyr Glu 
    1040                 1045                 1050             


Leu Glu  Glu Lys Tyr Tyr Lys  Leu His Gly Glu Asn  Ile Asn Ile 
    1055                 1060                 1065             


Glu Lys  Gly Ala Leu Leu Tyr  Gln Ile Val Ala Met  Tyr Ser His 
    1070                 1075                 1080             


Glu Leu  Pro Ile Tyr Lys Val  Asp Glu Ser Gly Ile  Ala Ile Leu 
    1085                 1090                 1095             


Ala Glu  Lys Gln Gly Ser Ser  Gly Ala Ser Ile Lys  Ser Phe Val 
    1100                 1105                 1110             


Thr Glu  Tyr Cys Lys Glu Glu  Met Lys Lys Ala His  Thr Tyr Glu 
    1115                 1120                 1125             


Asn Gly  Leu Glu Leu Phe Glu  Asp Val Asn Gln His  Asp Asp Leu 
    1130                 1135                 1140             


Ser Lys  Leu Arg Asn Asp Phe  Ala His Met Arg Tyr  Met Ser Ala 
    1145                 1150                 1155             


Arg Asp  Lys Ser Ile Met Asp  Ile Val Ser Glu Ile  Tyr Asn Gly 
    1160                 1165                 1170             


Phe Phe  Ile Tyr Asp Thr Lys  Leu Lys Lys Ser Val  Ser Phe Ile 
    1175                 1180                 1185             


Phe Lys  Asn Ile Leu Met Arg  Tyr Ala Val Asp Val  Asn Ile Glu 
    1190                 1195                 1200             


Phe Cys  His Lys Gly Asp Asn  Glu Asp Thr Asn Asn  Leu Ile Arg 
    1205                 1210                 1215             


Ile Lys  Asp Glu Val Gly Leu  Tyr Ser Asp Lys Tyr  Thr Tyr Lys 
    1220                 1225                 1230             


Val Glu  Asp Asn Asp Thr Val  Asp Ile Glu Val Arg  Asn Ser Glu 
    1235                 1240                 1245             


Phe Leu  Glu Gln Leu Lys Lys  Leu Leu Glu Tyr Lys  Lys Glu Ser 
    1250                 1255                 1260             


Glu Gly  Ser Glu Leu 
    1265             


<210>  740
<211>  1143
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  740

Met Arg Val Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Val Tyr Ser Gly 
            20                  25                  30          


Gln Pro Val Ser Asn Glu Thr Cys Asn Ile Leu Pro Glu Lys Lys Arg 
        35                  40                  45              


Gln Ser Phe Asp Leu Ser Ile Glu Asn Lys Thr Leu Lys Arg Arg Asp 
    50                  55                  60                  


Asp Val Asp Lys Thr Lys Lys Gly Lys Tyr Asp Ile Val Arg Lys Ile 
65                  70                  75                  80  


Ile Lys Tyr Gly Glu Leu Pro Gln Ser Ile Asn Asp Val Asp Ile Leu 
                85                  90                  95      


Glu Phe Leu Asn His Lys Phe Gln Lys Pro Val Lys Tyr Trp Lys Asn 
            100                 105                 110         


Gly Lys Glu Glu Ser Phe Asn Leu Thr Leu Leu Ile Val Glu Ala Val 
        115                 120                 125             


Lys Thr Gln Asp Arg Gln Lys Leu Gln Pro Tyr Tyr Asp Trp Lys Thr 
    130                 135                 140                 


Trp Tyr Ile Gln Thr Lys Ser Asp Leu Leu Lys Lys Ser Ile Glu Asn 
145                 150                 155                 160 


Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg Lys Lys Ala Leu 
                165                 170                 175     


Leu Ala Trp Glu Thr Glu Phe Thr Thr Ser Gly Lys Ile Asp Leu Thr 
            180                 185                 190         


His Tyr His Lys Val Tyr Met Thr Asp Val Leu Cys Thr Ala Leu Gln 
        195                 200                 205             


Lys Val Glu Pro Ser Thr Asp Lys Lys Gly Lys Ile Asn Thr Asn Ala 
    210                 215                 220                 


Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Thr His Gln Pro Ala Ile 
225                 230                 235                 240 


Phe Gly Thr Arg Gln Ala Pro Asn Asn Val Asn Arg Ala Asp Asp Arg 
                245                 250                 255     


Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu Glu His Tyr Phe 
            260                 265                 270         


Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Ala Asp Asp Ile Glu His 
        275                 280                 285             


Tyr Leu Lys Thr Gln Thr Leu Lys Thr Thr Ile Glu Lys Gln Leu Val 
    290                 295                 300                 


Asn Ala Ile Arg Ala Asn Ile Ile Gln Gln Gly Lys Thr Asn His His 
305                 310                 315                 320 


Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile Arg Ile Lys Thr 
                325                 330                 335     


Asn Glu Ala Phe Val Leu Asn Leu Thr Gly Thr Cys Ala Phe Ala Ala 
            340                 345                 350         


Asn Asn Ile Arg Asn Met Val Asp Asn Glu Gln Thr Asn Asp Ile Leu 
        355                 360                 365             


Gly Lys Gly Asp Phe Ile Lys Ser Leu Leu Lys Asp Asn Thr Asn Gly 
    370                 375                 380                 


Gln Leu Tyr Ser Phe Phe Phe Gly Glu Ser Leu Ser Thr Asn Lys Ala 
385                 390                 395                 400 


Glu Lys Glu Thr Gln Leu Trp Gly Ile Arg Gly Ala Val Gln Gln Ile 
                405                 410                 415     


Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu Lys Thr Val Phe 
            420                 425                 430         


Asn Ile Ser Asn Phe Glu Asn Pro Thr Ile Thr Asp Pro Lys Gln Gln 
        435                 440                 445             


Thr Asn Tyr Ala Asp Thr Ile Tyr Lys Ala Leu Phe Ile Lys Glu Leu 
    450                 455                 460                 


Glu Lys Ile Pro Asn Ala Phe Ala Gln Gln Leu Lys Thr Gly Gly Ala 
465                 470                 475                 480 


Leu Ser Tyr Tyr Thr Ile Glu Asn Leu Lys Ser Leu Leu Thr Thr Phe 
                485                 490                 495     


Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala Pro Gly Phe Lys 
            500                 505                 510         


Lys Val Phe Asn Gly Gly Ile Asn Tyr Gln Asn Ala Lys Gln Asp Glu 
        515                 520                 525             


Ser Phe Tyr Glu Leu Met Leu Glu Arg Tyr Leu Arg Lys Glu Asn Phe 
    530                 535                 540                 


Ala Glu Glu Ala Tyr Asn Ala Arg Tyr Phe Leu Leu Lys Leu Ile Tyr 
545                 550                 555                 560 


Asn Asn Leu Phe Leu Pro Gly Phe Thr Arg Asp Arg Lys Ala Phe Ala 
                565                 570                 575     


Asp Ser Val Gly Phe Val Gln Met Gln Asn Lys Lys Gln Ala Glu Lys 
            580                 585                 590         


Val Asn Pro Lys Lys Arg Glu Ala Tyr Ala Phe Glu Ala Val Arg Pro 
        595                 600                 605             


Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala Tyr Val Gln Ser 
    610                 615                 620                 


Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys Ala Thr Asp Glu 
625                 630                 635                 640 


Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val Phe Val Lys Gly 
                645                 650                 655     


Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe Val Gln Val Pro 
            660                 665                 670         


Gln Pro Gln Leu Thr Ala Thr Ala Ser Asn Gln Gln Lys Ala Asp Lys 
        675                 680                 685             


Leu Asn Gln Leu Glu Ala Ser Ile Thr Ala Asp Cys Lys Leu Thr Pro 
    690                 695                 700                 


Gln Tyr Ala Lys Ala Asp Asn Ala Thr His Ile Ala Phe Tyr Val Phe 
705                 710                 715                 720 


Cys Lys Leu Leu Asp Ala Gly His Leu Ser Asn Leu Arg Asn Glu Leu 
                725                 730                 735     


Ile Lys Phe Arg Glu Ser Val Asn Glu Phe Lys Phe His His Leu Leu 
            740                 745                 750         


Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val Val Pro Thr Asp 
        755                 760                 765             


Tyr Arg Asp Leu Tyr Ser Ser Glu Ala Asp Cys Leu Ala Arg Leu Arg 
    770                 775                 780                 


Pro Phe Ile Glu Gln Gly Ala Asp Ile Thr Asn Trp Ser Asp Leu Phe 
785                 790                 795                 800 


Val Gln Ser Asp Lys His Ser Pro Val Ile His Ala Asn Ile Glu Leu 
                805                 810                 815     


Ser Val Lys Tyr Gly Thr Thr Lys Leu Leu Glu Gln Ile Ile Asn Lys 
            820                 825                 830         


Asp Pro Gln Phe Lys Thr Thr Glu Ala Asn Phe Thr Ala Trp Asn Thr 
        835                 840                 845             


Ala Gln Lys Ser Ile Glu Gln Leu Ile Lys Gln Arg Glu Asp His His 
    850                 855                 860                 


Glu Gln Trp Val Lys Ala Lys Asn Ala Asp Asp Lys Glu Lys Gln Glu 
865                 870                 875                 880 


Arg Lys Arg Glu Lys Ser Asn Phe Ala Gln Lys Phe Ile Glu Lys His 
                885                 890                 895     


Gly Asp Asp Tyr Leu Asp Ile Cys Asp Tyr Ile Asn Thr Tyr Asn Trp 
            900                 905                 910         


Leu Asp Asn Lys Met His Phe Val His Leu Asn Arg Leu His Gly Leu 
        915                 920                 925             


Thr Ile Glu Leu Leu Gly Arg Met Ala Gly Phe Val Ala Leu Phe Asp 
    930                 935                 940                 


Arg Asp Phe Gln Met Leu Asp Ala Lys Arg Ile Ser Asp Leu Tyr Gln 
945                 950                 955                 960 


Leu Lys Ser Phe Ile Ser Phe Arg Glu Ile Thr Ser Glu Leu Asp Lys 
                965                 970                 975     


Asn Asn Asp Ile Thr Glu Ile Asn Leu Ile Lys Asp Lys Glu Ile Ile 
            980                 985                 990         


Lys Arg Asp Gly Thr Pro Ile Thr  Glu Ala Asp Arg Asn  Ser Leu Lys 
        995                 1000                 1005             


Ser Cys  Ile Gln Ser Lys Arg  Glu Tyr Tyr Gln Lys  Thr Tyr Phe 
    1010                 1015                 1020             


Lys Glu  His Thr Asn Pro Phe  Thr Asp Arg Asn Tyr  Ile Ala His 
    1025                 1030                 1035             


Phe Asn  Tyr Leu Ser Thr Asn  Thr Gly Asn His Ser  Leu Ile Lys 
    1040                 1045                 1050             


Leu Ile  Asn Lys Leu Arg Asp  Leu Leu His Tyr Asp  Arg Lys Leu 
    1055                 1060                 1065             


Lys Asn  Ala Val Ser Lys Ala  Phe Ile Asp Leu Phe  Asp Lys His 
    1070                 1075                 1080             


Gly Met  Ile Leu Lys Leu Lys  Leu Asn Thr Asp His  Gln Leu Glu 
    1085                 1090                 1095             


Val Glu  Ser Leu Glu Pro Lys  Lys Ile Tyr His Leu  Gly Ser Ser 
    1100                 1105                 1110             


Ala Lys  Asp Lys Pro Glu Tyr  Gln Tyr Cys Thr Asn  Gln Val Met 
    1115                 1120                 1125             


Met Ala  Tyr Cys Asn Met Cys  Arg Ser Leu Leu Glu  Met Lys Lys 
    1130                 1135                 1140             


<210>  741
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  741

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  742
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  742

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Thr Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  743
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  743

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Pro Gly Thr Asp Thr 
            20                  25                  30          


Ile Gly Leu Lys Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Asp Lys Pro Lys Lys 
    50                  55                  60                  


Trp Lys Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Glu Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Ser Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Met Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Tyr Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ser Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Gln Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Leu Tyr Asn Ser Val Phe 
            660                 665                 670         


Ile Arg Lys Asn Phe Pro Glu Asp Ile Ser Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val Tyr Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Asp Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Asp Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asn  Ser Glu Lys Lys Glu  Ala Tyr Gln Lys Ile  Glu Val Asn 
    1100                 1105                 1110             


Gly Asp  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Val  Tyr Ala Pro Asp Glu  Lys Gly Asp 
    1130                 1135                 1140             


Ile Leu  Lys Glu Gln Cys Thr  Lys Gly Gly Ala Gly  Gly Lys Ile 
    1145                 1150                 1155             


Ser Ala  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Lys Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Lys Gln 
    1250                 1255                 1260             


Thr Thr  Ser Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Ser Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Lys  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Val Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Gly Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Pro Asn 
    1370                 1375                 1380         


<210>  744
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  744

Met Lys Ile Thr Lys Ile Asp Gly Ile Ser His Lys Lys Tyr Ile Lys 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Lys Thr Asp Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Thr Ile Arg Leu Asp Thr Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Thr Leu 
    50                  55                  60                  


Lys Glu Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Gly Ile Leu 
65                  70                  75                  80  


Tyr Leu Lys Asp Arg Arg Glu Lys Asn Gln Leu Gln Asn Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Leu Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Asn Asp Phe Glu Lys Lys Leu Asp Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Leu Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Ile Lys Lys Val Glu Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Phe Tyr Asn Tyr Tyr Lys Asp Ser Val Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Ile Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Asn Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys Tyr Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Thr Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Met 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asn Val Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Ser Lys Glu Lys Leu Asn Asp Glu 
        275                 280                 285             


Asn Ile Lys Tyr Val Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Ser Phe Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Val Gly Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Thr Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Ile Lys Gly Lys Thr Val Lys Asn Lys 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Ile Ser Gly Glu Ile Asp Lys Leu Tyr Asp 
            420                 425                 430         


Asn Asn Lys Gln Asn Glu Val Lys Lys Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asn Ser Lys Lys Glu Ile Glu Asp Phe Phe Ser 
    450                 455                 460                 


Asn Ile Asp Glu Thr Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Thr Phe Lys Asn Ile Val 
                485                 490                 495     


Pro Ser Gln Ile Ser Lys Lys Met Phe His Asp Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Lys Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Asn Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Cys Ile Tyr Trp 
                565                 570                 575     


Lys Ile Pro Lys Ala Asn Asp Asn Asn Lys Thr Lys Glu Ile Thr Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Thr Lys Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asn Leu Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Lys Ile Leu Lys Tyr Thr Glu Ser Leu Asn Ile Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Phe Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Ala Phe Ser Asp Gln Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Val Lys Asp Asn Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Leu Lys Glu Leu Lys Glu Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn Tyr Thr Met Gln Gln Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Lys Lys Asp Glu Lys Phe Asn Asp Glu Asp Tyr Lys 
        915                 920                 925             


Lys Tyr Glu Lys Val Ile Arg Asn Ile Gln Gln Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Ser Leu Leu Leu 
945                 950                 955                 960 


Arg Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Asp 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Asn Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Ser Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asp  Met Glu Lys Ile Ser  Ile Tyr Ser Asp Lys  Lys Leu Lys 
    1025                 1030                 1035             


Glu Leu  Lys Lys Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  Asn Ala Glu Val Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Ile Met Lys Ser  Ile Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Thr Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Glu Lys Leu Thr Thr  Asn Arg Asn Ser Lys  Glu Leu Cys 
    1130                 1135                 1140             


Lys Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Glu  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Lys 
    1160     


<210>  745
<211>  1107
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  745

Met Gly Ser Gly Lys Tyr Arg Ile Thr Lys Ile Ala Arg Asp Trp Asp 
1               5                   10                  15      


Glu Asn Lys Lys Arg Ile Ile Leu Lys Arg Ile Val Ser Asp Gly Glu 
            20                  25                  30          


Val Lys Tyr Val Asn Glu Asn Asn Asn Val Asp Ile Asp Ile Thr Glu 
        35                  40                  45              


Thr Tyr Tyr Arg Ile Leu Ser Asn Asn Lys Ala Lys Phe Leu Gly Ser 
    50                  55                  60                  


Asn Glu Gln Phe Ile Phe Lys Val Asn Lys Met Lys Arg Asn Ile Lys 
65                  70                  75                  80  


Asn Asp Cys Val Ile Ile Lys Asp Tyr Thr Glu Glu Glu Phe Glu Lys 
                85                  90                  95      


Leu Asp Lys Lys Ile Phe Phe Ser Arg Lys Ile Lys Val Asn Asn Lys 
            100                 105                 110         


Asp Arg Glu Lys Ile Cys Arg Asn Phe Tyr Glu Asp Glu Arg Glu Ile 
        115                 120                 125             


Met Lys Lys Arg Leu Glu Glu Ala Lys Lys Phe Asn Asn Ile Ile Phe 
    130                 135                 140                 


Ile Leu Leu Glu Phe Ile Gln Gln Ile Ala Lys Gln Glu Phe Glu Asn 
145                 150                 155                 160 


Gln Lys Glu Leu Glu Asn Trp Phe Ser Tyr Gly Gly Glu Lys Tyr Cys 
                165                 170                 175     


Lys Glu Ile Phe Lys Ile Tyr Ser Asn Met Ser Gln Lys Glu Lys Tyr 
            180                 185                 190         


Phe Lys Leu Leu Gly His Arg Asn Gln Gly Ile Ala Ser Ile Tyr Asp 
        195                 200                 205             


Glu Lys Lys Glu Thr Leu Gln Arg Arg Leu Lys Leu Gly Asp Tyr Ser 
    210                 215                 220                 


Lys Tyr Asp Leu Lys Arg Tyr Tyr Gln Lys Asp Tyr Lys Glu Glu Ala 
225                 230                 235                 240 


Ile Lys Glu Leu Lys Asp Lys Asn Lys Glu Gly Leu Glu Arg Glu Ile 
                245                 250                 255     


Glu Glu Leu Ile Lys Lys Asn Tyr Lys Ile Asp Lys Leu Cys Asp Glu 
            260                 265                 270         


Ile Ser Asn Leu Glu Phe Ser Phe Val Glu Ser Lys Lys Glu Asn Lys 
        275                 280                 285             


Asp Lys Met Ser Glu Ile Ile Val Lys Ile Lys Glu His Tyr Lys Lys 
    290                 295                 300                 


Asn Val Asn Val Glu Glu Glu Leu Glu Asn Lys Glu Lys Tyr Ile Leu 
305                 310                 315                 320 


Ser Ile Ile His Asn Tyr Val Lys Gly Arg Tyr Arg Lys Cys Leu Glu 
                325                 330                 335     


Leu Gln Gln Lys Glu Asn Val Asp Phe Glu Asn Leu Glu Lys Arg Ile 
            340                 345                 350         


Lys Glu Ile Phe Asp Ser Asn Glu Val Thr Lys Lys Leu Lys Lys Ser 
        355                 360                 365             


Ile Ile Asn Lys Val Asn Ser Tyr Lys Ile Phe Glu Met Lys Phe Gln 
    370                 375                 380                 


Asn Pro Asn Val Glu Ser Ser Asp Asp Leu Glu Ile Leu Lys Ala Glu 
385                 390                 395                 400 


Glu Thr Phe Leu Asn Lys Leu Ser Thr Ala Val Ser Lys Val Gly Tyr 
                405                 410                 415     


Ile Leu Asn Ile Leu Leu Glu Ile His Phe Arg Asn Asp Ile Leu Gln 
            420                 425                 430         


Asp Tyr Asn Gln Val Glu Lys Leu Trp Lys Ser Asp Ser Phe Gln Lys 
        435                 440                 445             


Ile Cys Ala Ile Tyr Pro Glu Ile Asn Asn Asp Glu Lys Leu Leu Lys 
    450                 455                 460                 


Gly Met Ile Tyr Phe Ile Gln Gly Leu Arg Gln Gln Val Leu His Pro 
465                 470                 475                 480 


Lys Ile Leu Trp Glu Lys Gln Asn Ile Tyr Asn Ala Glu Asn Ile Lys 
                485                 490                 495     


Glu Lys Glu Lys Ile Val Ser Val Lys Leu Gln Asn Glu Gly Glu Ala 
            500                 505                 510         


Tyr Asn Lys Lys Gly Ile Gln Asn Tyr Phe Glu Asn Val Leu Lys Lys 
        515                 520                 525             


Ile Pro Asp Tyr Phe Ile Glu Lys Tyr Glu Ser Asn Asn Val Phe Asn 
    530                 535                 540                 


Ile Tyr Arg Asn Ser Val Asp Lys Ile Met Glu Val Val Lys Asn Phe 
545                 550                 555                 560 


Asn Phe Lys Glu Asn Asn Thr Ile Asp Tyr Leu Phe Pro Lys Phe His 
                565                 570                 575     


Lys Ile Tyr Lys Arg Met Cys Lys Ser Glu Asn Ile Asp Asp Arg Gln 
            580                 585                 590         


Asn Gly Ala Arg Lys Tyr Leu Leu Gln Thr Ile Tyr Tyr Tyr Tyr Phe 
        595                 600                 605             


Gln Tyr Glu Ile Glu Asn Asp Lys Asn Asn Met Ser Lys Tyr Leu Asn 
    610                 615                 620                 


Leu Tyr Arg Asn Lys Ile Lys Val Lys Lys Ile Ser Tyr Ser Tyr Ile 
625                 630                 635                 640 


Ile Asp Asn Lys Ala Val Asn Asn Lys Asn Ile Glu Ile Leu Tyr Arg 
                645                 650                 655     


Asn Ile Gln Arg Glu Gly Met Leu Asn Asn Arg Leu Leu Gln Met Asn 
            660                 665                 670         


Asn Glu Trp Ile Glu Phe Ile Val Val Gln Phe Ser Glu Phe Leu Thr 
        675                 680                 685             


Lys Lys Lys Leu Asn Trp Ile Leu Asp Asp Leu Ser Glu Tyr Lys Lys 
    690                 695                 700                 


Lys Glu Lys Leu Asp Glu Asn Asp Lys Asn Glu Leu Leu Lys Ile Phe 
705                 710                 715                 720 


Lys Gln Lys Met Asn Lys Asn Ile Thr Tyr Ser Asn Asp Ser Tyr Ala 
                725                 730                 735     


Phe Ile Ser Leu Ala Gln Phe Leu Asp Leu Lys Glu Ile Ser Asn Leu 
            740                 745                 750         


Ile His Asp Ile Lys Lys Phe Val Gln Phe Arg Glu Lys Asn Ile Leu 
        755                 760                 765             


Lys Tyr Asn Pro Glu Lys Asn Lys Ile Tyr Ile Glu Glu Leu Arg Lys 
    770                 775                 780                 


Ile Leu Tyr Ile Leu Lys Val Met Leu Glu His Lys Glu Arg Val Ile 
785                 790                 795                 800 


Gln Lys His Tyr Leu Gly Ser Tyr Asp Glu Asp Ile Ser Ile Met Tyr 
                805                 810                 815     


Gly Lys Asp Ile Glu Lys Lys Asp Ile Lys Asp Ile Glu Ile Lys Ile 
            820                 825                 830         


Lys Asn Lys Asn Gln Glu Val Ile Asn Gln Pro Leu Tyr Lys Ser Gly 
        835                 840                 845             


Asn Asp Glu Asn Ser Ser Trp Ile Ile Leu Tyr Gly Ile Glu Gln Ala 
    850                 855                 860                 


Lys Arg Asn Gly Thr Phe Lys Phe Phe Glu Gly Phe Phe Asn Leu Asn 
865                 870                 875                 880 


Asp Asp Ile Lys Leu Cys Lys Glu Asp Ile Glu Lys Tyr Glu Lys Leu 
                885                 890                 895     


Tyr Asn Glu Lys Glu Glu Asn Gln Lys Lys Val Asp Glu Tyr Ile Ser 
            900                 905                 910         


Lys Leu Asn Asn Asp Ile Glu Lys Ile Asn Asn Asp Ile Asn Ile Glu 
        915                 920                 925             


Lys Thr Asn Asp Asn Lys Gln Leu Phe Tyr Tyr Tyr Lys Asn Met Ile 
    930                 935                 940                 


Tyr Gly Asp Gly Leu Lys Lys Gly Tyr Asp Phe Ile Asn Asp Ile Tyr 
945                 950                 955                 960 


Ser His Tyr Leu Ser Trp Ala Tyr Arg Ile Glu Arg Asp Cys Lys Ile 
                965                 970                 975     


Tyr Lys Ile Lys Glu Tyr Glu Asn Lys Lys Asn Phe Asn Glu Tyr Lys 
            980                 985                 990         


Phe Lys Glu Tyr Lys Ser Ile Lys  Tyr Phe Arg Asn Glu  Ile Ala His 
        995                 1000                 1005             


Phe Asn  Tyr Phe Gln Lys Thr  Asn Lys Ser Leu Leu  Glu Leu Leu 
    1010                 1015                 1020             


Asn Asn  Phe Tyr Asp Ile Phe  Asp Tyr Asn Leu Lys  Tyr Gln Arg 
    1025                 1030                 1035             


Asp Val  Gln Lys Val Ile Asn  Asn Ile Phe Glu Lys  Tyr Gln Val 
    1040                 1045                 1050             


Ile Arg  Glu Asp Gly Gly Pro  Val Ile Phe Tyr Cys  Lys Ile Asp 
    1055                 1060                 1065             


Lys Lys  Leu Lys Leu Ser Glu  Asn Ile Ile Pro Lys  Lys His Leu 
    1070                 1075                 1080             


Lys Cys  Ser Lys Ile Lys Leu  Ile His Glu Lys Tyr  Val Glu Phe 
    1085                 1090                 1095             


Phe Arg  Lys Leu Phe Glu Tyr  Lys Lys 
    1100                 1105         


<210>  746
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  746

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Pro Gly Thr Asp Thr 
            20                  25                  30          


Ile Gly Leu Lys Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Asp Lys Pro Lys Lys 
    50                  55                  60                  


Trp Lys Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Glu Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Ser Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Met Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Tyr Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ser Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Gln Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Phe 
            660                 665                 670         


Ile Arg Lys Asn Phe Pro Glu Asp Ile Ser Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val Tyr Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Asp Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Asp Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asn  Ser Glu Lys Lys Glu  Ala Tyr Gln Lys Ile  Glu Val Asn 
    1100                 1105                 1110             


Gly Asp  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Val  Tyr Ala Pro Asp Glu  Lys Gly Asp 
    1130                 1135                 1140             


Ile Leu  Lys Glu Gln Cys Thr  Lys Gly Gly Ala Gly  Gly Lys Ile 
    1145                 1150                 1155             


Ser Ala  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Lys Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Lys Gln 
    1250                 1255                 1260             


Thr Thr  Ser Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Ser Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Lys  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Val Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Gly Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Pro Asn 
    1370                 1375                 1380         


<210>  747
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  747

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Pro Gly Thr Asp Thr 
            20                  25                  30          


Ile Gly Leu Lys Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Asp Lys Pro Lys Lys 
    50                  55                  60                  


Trp Lys Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Glu Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Ser Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Met Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Tyr Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ser Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Gln Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Phe 
            660                 665                 670         


Ile Arg Lys Asn Phe Pro Glu Asp Ile Ser Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val Tyr Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Asp Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Asp Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asn  Ser Glu Lys Lys Glu  Ala Tyr Gln Lys Ile  Glu Val Asn 
    1100                 1105                 1110             


Gly Asp  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Val  Tyr Ala Pro Asp Glu  Lys Gly Asp 
    1130                 1135                 1140             


Ile Leu  Lys Glu Gln Cys Thr  Lys Gly Gly Ala Gly  Gly Lys Ile 
    1145                 1150                 1155             


Ser Ala  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Lys Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Lys Gln 
    1250                 1255                 1260             


Thr Thr  Ser Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Ser Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Lys  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Val Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Gly Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Pro Asn 
    1370                 1375                 1380         


<210>  748
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  748

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Ile Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Leu Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Glu 
        755                 760                 765             


Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Arg Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Asp Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Ile Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1400                 1405                 1410         


<210>  749
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  749

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  750
<211>  1287
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  750

Met Arg Ile Gly Lys Val Gln Gly Arg Thr Phe Thr Gly Phe Asp Asn 
1               5                   10                  15      


Ala Arg Gly Lys Thr Leu Arg Arg Arg Leu Leu Thr Arg Pro Asp Asn 
            20                  25                  30          


Glu Ala Arg Ser Leu Ser Glu His Leu Ala His Asp Pro Lys Ala Leu 
        35                  40                  45              


Ile Gly Gln Ala Ile Ser Arg Ile Asp Thr Ile Tyr Gln Lys Pro Lys 
    50                  55                  60                  


Thr Gly Lys Pro Thr Pro Glu Gln Phe Gly His Arg Asp Thr Leu Gly 
65                  70                  75                  80  


Trp Ala Tyr Trp Lys Leu Leu Val Ala Ser Tyr Pro Glu Val Glu Gly 
                85                  90                  95      


His Arg Asp Leu Phe Val Arg Arg Leu His Pro Tyr Gly Asp Thr Pro 
            100                 105                 110         


Pro Lys Ser His Gly Gln Lys Glu Gly Glu His Gln Lys Gly Gly Lys 
        115                 120                 125             


Pro Gln Leu Glu Gly Arg Trp His Gly Val Met Ala Gln His Gly Lys 
    130                 135                 140                 


Asn Pro Asp Gln Ile Ala Ala Arg Leu Phe Asp His Leu His Asn Ser 
145                 150                 155                 160 


Glu Leu Arg Phe Gly Gly Thr Ala Ser Gly Glu Pro Arg Thr Arg Pro 
                165                 170                 175     


Gly Lys Glu Ala Thr Pro Thr Gly Leu Ile Gly Ala Arg Ala Lys Thr 
            180                 185                 190         


Ile Glu His Ser Val Leu Pro Arg Asp Ala Lys Arg Phe Val Ala Glu 
        195                 200                 205             


Trp Arg Gly Glu Asp Gln Glu Arg Tyr Ala Gly Ala Arg Asp Ile Ala 
    210                 215                 220                 


Ala Ala Ile Ser Ala Gly Leu Asn Asp Lys Asp Gln Lys Ser Gly Ser 
225                 230                 235                 240 


Gly Arg Lys Ser Ala Val Ile Gly Lys Leu Leu Ser Asp His Leu Glu 
                245                 250                 255     


Thr Leu Thr Gly Asn Arg Lys Cys Arg Phe Asp Pro Lys Ser Thr Ala 
            260                 265                 270         


Glu Thr Leu Glu Leu Arg Asp Gly Glu Ser Val Asp Asp Arg Arg Arg 
        275                 280                 285             


Ile Leu Glu Leu His Ala Glu Val Lys Ala Thr Tyr Lys Arg Met Ala 
    290                 295                 300                 


Ala Trp Lys Pro Ala Lys Leu Pro Arg Asn Ser Asp Glu Leu Phe Arg 
305                 310                 315                 320 


Leu Val Arg Gln Gln Ala Asp Asn Arg Ile Leu Asn His Leu Val Arg 
                325                 330                 335     


Val Gly Arg Ile Ser Val Tyr Ser Glu Gln Ser Asp Ala Leu Ser Glu 
            340                 345                 350         


Ser Gln Phe Trp Thr Ser Gly Gly Gln Thr Gln Ile Lys Glu Ser Glu 
        355                 360                 365             


Val Phe Ala Arg Leu Trp Ile Gly Ala Ile Ser Arg Ala Ser Tyr Ser 
    370                 375                 380                 


Met Lys Ala Trp Leu Glu Pro Glu Gly Thr Val Phe Asn Pro Ser Ile 
385                 390                 395                 400 


Asn Asp Phe Asp Val Thr Ser Ser His Asn Thr Asn Arg Ile Leu Glu 
                405                 410                 415     


Asp Ser Gly Arg Leu Ser Asn Ala Met Ala Arg Arg Ala Ile Tyr Phe 
            420                 425                 430         


Gly Glu Thr Pro Glu Phe Asp Ala Leu Gly Glu Glu Asp Gln Arg Val 
        435                 440                 445             


Leu Val Lys Lys Cys Leu Asp Ala Leu Ser Ala Cys Arg Asn Arg Thr 
    450                 455                 460                 


Phe His His Gly Gln Arg Ala Lys Phe Leu Lys Glu Val Arg Lys Gly 
465                 470                 475                 480 


Leu Lys Glu Lys Glu Ala Asp Ser Ala Gly Pro Ala Ala Trp Glu Gly 
                485                 490                 495     


Ile Arg Glu Val Ile Gln Ala Asp Ala Arg Asn Leu Gly Ala Arg Leu 
            500                 505                 510         


Leu Gln Asp Leu Thr Gly Ala Lys Val His Ser Phe Ala Thr Asp Pro 
        515                 520                 525             


Glu Phe Arg His Leu Tyr Glu Ser Val Ala Ala Thr Leu Thr Ala Gly 
    530                 535                 540                 


Gly Glu Leu Glu Ala Ala Leu Pro Arg Leu Lys Asn Val Leu Lys Arg 
545                 550                 555                 560 


Ala Glu Gly Val Arg Cys Tyr Leu Asp Thr Pro Ser Gln Arg Arg Glu 
                565                 570                 575     


Gly Asp Glu Ser Leu Ile Ala Arg Leu Pro Val Ala Pro Val Pro Arg 
            580                 585                 590         


Glu Leu Asp Asp Ala Ala Thr Lys Ala Arg His Ser Ala Leu Leu Arg 
        595                 600                 605             


Leu Tyr Asp Gly Pro Phe Arg Pro Trp Ala Thr Glu Leu Arg Gly Glu 
    610                 615                 620                 


Arg Leu Ser Asp Tyr Ala Ala Arg Ala Lys Arg Leu Ala Thr Arg Leu 
625                 630                 635                 640 


Ala Lys Ser Thr Asn Thr Ala Ser Pro Tyr Pro Asp Ser Val Glu Gly 
                645                 650                 655     


Arg Ser Val Arg Leu Arg Asp Pro Ile Thr Ala Asp Thr Ala Pro Glu 
            660                 665                 670         


Thr Leu Lys Thr Tyr Leu Ser Ala Leu Thr Ala Glu Thr Ala Thr Glu 
        675                 680                 685             


Phe Arg Val Gln Lys Gly Tyr Glu Ser Asp Gly Glu Lys Ala Lys Glu 
    690                 695                 700                 


Gln Ala Glu Phe Ile Glu Asp Phe Arg Arg Asp Met Ile Ala Leu Ala 
705                 710                 715                 720 


Phe Gln Asp Phe Ile Arg Asp His Gly Phe Ala Trp Leu Leu Asp Ile 
                725                 730                 735     


Ala Ser Lys Ala Glu Pro Ser Asn Asp Ala Pro Asn Leu Pro Asp Pro 
            740                 745                 750         


Val Asp Thr Gly Lys Asp Thr Val Phe Glu Asp Trp Gln Ala Leu Leu 
        755                 760                 765             


Tyr Leu Phe Leu His Phe Val Pro Ala Asp Asp Val Ser Gln Leu Leu 
    770                 775                 780                 


His Gln Leu Arg Lys Trp Asp Ala Leu Gln Asp Lys Tyr Glu Leu Ala 
785                 790                 795                 800 


Glu Pro Gly Glu Thr Leu Gly Gln Thr Lys Ala Asp Thr Arg Lys Ile 
                805                 810                 815     


Val Gly Gln Phe Arg Asp Cys Leu Thr Leu Phe Leu Lys Thr Gly Asp 
            820                 825                 830         


Ala Arg Phe Asp Gly Glu Gly Val Glu Leu Pro Leu Ser Asp Phe Gln 
        835                 840                 845             


Glu Leu Phe Glu Ser Pro Ala Thr Phe Lys Glu Leu Phe Leu Ala Glu 
    850                 855                 860                 


Pro Ala Glu Asn Asp Ala Ser Glu Thr Asp Asp Gln Asp Ala Pro Gly 
865                 870                 875                 880 


Glu Lys His Arg Val Thr Arg Thr Arg Arg Gly Leu Arg Gln Ile Leu 
                885                 890                 895     


Arg Tyr Asn His Met Pro Val Leu Arg Asp Leu Phe Leu Ala His Lys 
            900                 905                 910         


Val Thr Asp Ala Glu Val Asp Gly Leu Gln Ala Leu Glu Val Asp Asp 
        915                 920                 925             


Pro Gln Thr Gly Glu Ser Gln Ile Gly Ala Ala Gln Arg Ile Arg Thr 
    930                 935                 940                 


Glu Ile His His His Thr Ser Asn Asp Lys Gln Ile Ser Glu Ala Lys 
945                 950                 955                 960 


Val Glu Glu Tyr Arg Arg Ala Leu Ser Thr Ile Glu Arg His Arg Phe 
                965                 970                 975     


Leu Val Gly Arg Val Tyr Leu Gly Asp His Ile Arg Val His Lys Leu 
            980                 985                 990         


Met Met Asp Val Met Gly Arg Leu  Val Asp Phe Ala Gly  Ala Trp Glu 
        995                 1000                 1005             


Arg Glu  Ala Ala Asp Gly Asp  Arg Lys Gly Phe Ile  Ser Arg Ala 
    1010                 1015                 1020             


Ile Ala  Leu Pro Glu Val Ala  Glu Gly Tyr Ala Ala  Asp Arg Leu 
    1025                 1030                 1035             


Lys Thr  Val Ala Arg Arg Val  Leu Asp Asp Gly Glu  Ala Arg Arg 
    1040                 1045                 1050             


Ile Arg  Asn Asp Leu Gly His  Phe Asn Asp Leu Ala  Pro Thr Ser 
    1055                 1060                 1065             


Gly Pro  Ala Asn Leu Thr Phe  Val Val Asn Arg Ala  Arg Arg Met 
    1070                 1075                 1080             


Met Arg  His Asp Arg Lys Arg  Lys Asn Ala Val Thr  Lys Ser Val 
    1085                 1090                 1095             


Ile Glu  Ile Leu Asn Arg Gln  Gly Leu Gly Ile Glu  Trp Thr Met 
    1100                 1105                 1110             


Arg Asn  His Glu Leu Cys Glu  Ala Lys Leu Trp Gln  Asn Pro Val 
    1115                 1120                 1125             


Lys His  Leu Gly Phe Ala Thr  Leu Glu Gly Arg Gly  Lys Lys Trp 
    1130                 1135                 1140             


Arg Arg  Pro Phe Glu Ala Arg  Tyr Gly Asp Ala Tyr  Met Ala Met 
    1145                 1150                 1155             


Val Ala  Gln Leu Phe Asp Gly  Thr Val Thr Ser Pro  Pro Ala Lys 
    1160                 1165                 1170             


Gly Pro  Pro Gln Ser Gly Lys  Ser Gly Gly Lys Pro  Gly Lys Gly 
    1175                 1180                 1185             


Ala Glu  Gly Gly Ala Lys Glu  Lys Ser Arg Ser Pro  Thr Arg Met 
    1190                 1195                 1200             


Glu Glu  Gly Gly Val Tyr Glu  Gly Arg Val Ala Lys  Ala Lys Ser 
    1205                 1210                 1215             


Asp Lys  Gly Phe Gly Phe Leu  Leu Val Glu Gly Ala  Gln Glu Glu 
    1220                 1225                 1230             


Ile Phe  Leu His Ile Tyr Gly  Ile Ser Gly Asn Arg  Pro Ala Arg 
    1235                 1240                 1245             


Ile Glu  Asn Gly Gln Arg Tyr  Arg Phe Thr Leu Gly  Ile Asp Arg 
    1250                 1255                 1260             


Asp Arg  Glu Arg Arg Lys Glu  Arg Ala Trp Val Ala  Arg Glu Ala 
    1265                 1270                 1275             


Val Arg  Ile Asp Glu Asn Arg  Ser Lys 
    1280                 1285         


<210>  751
<211>  1315
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  751

Met Ile Ile Ile Lys Lys Phe Gly Arg Ser Val Ile Thr Gln Asp Lys 
1               5                   10                  15      


Asn Thr Asp Asn Lys Arg Glu Arg Glu Leu Asp Thr Ser Ala Arg Ala 
            20                  25                  30          


Lys Ala Lys Ser Gln Asn Ser Gln Val Phe Pro Phe Leu Asn Lys Lys 
        35                  40                  45              


Glu Asp Phe Ile Asn Leu Trp Ile Ser Glu Phe Asp Lys Leu Ile Tyr 
    50                  55                  60                  


Lys Pro Lys Gly Asp Asp Lys Pro Thr Lys Glu Met Tyr Thr Leu Arg 
65                  70                  75                  80  


Glu Ala Ala Gly Lys Gly Phe Leu Asn Tyr Trp Asn Gln Met Pro Met 
                85                  90                  95      


Val Ser Lys Lys Asp Gly Ala Phe Ser Asp Met Trp Met Ser Lys Val 
            100                 105                 110         


His Pro Tyr Gly Arg Gly Ile Thr Glu Phe Ser Pro Pro Leu Gln Leu 
        115                 120                 125             


Glu Lys Leu Ile Asp Gln Gly Leu Leu Ser Ala Met Gly Gly Ser Glu 
    130                 135                 140                 


Pro Leu Lys Asn Cys His Trp Asn Arg Val Thr Ser Asn Val Phe Lys 
145                 150                 155                 160 


Gly Leu Lys Val Gln Leu Asp Ile Leu Glu Ala Gln Ala Lys Asn Thr 
                165                 170                 175     


Phe Val Ile Lys Asn Lys Thr Asn Ser Lys Arg Asn Arg Pro Ala Ser 
            180                 185                 190         


Gln Asn Ile Lys Glu Phe Leu Leu Thr Asp Glu Thr Ala Phe Ile Asn 
        195                 200                 205             


Leu Trp Ile Ser Glu Phe Asp Lys Leu Ile Leu Lys Pro Gln Gly His 
    210                 215                 220                 


Asn Lys Pro Thr Glu Lys Met Tyr Asn Leu Arg Gln Gln Ala Gly Val 
225                 230                 235                 240 


Ala Phe Leu Asn Tyr Trp Lys Lys Lys Pro Leu Ile Pro Trp Ala Asn 
                245                 250                 255     


Ser Glu Ser Phe Pro Asp Lys Trp Met Leu Lys Val His Pro Tyr Gly 
            260                 265                 270         


Asp Lys Thr Ser Asn Asn Arg Ser Glu Thr Leu Ile Lys Ser Lys Trp 
        275                 280                 285             


Gly Ser Val Met Arg Ala Lys Glu Cys Leu Ser Asp Asp Gln Trp Glu 
    290                 295                 300                 


Gln Val Ala Phe Asn Val Tyr Ser His Leu Tyr Gly Asn Gln Lys Thr 
305                 310                 315                 320 


Leu Asn Gly Lys Asn Lys Glu Ile Gly Leu Ile Ala Ala Arg Ala Asn 
                325                 330                 335     


Ser Ile Lys Gln Asn Val Pro Ser Tyr Thr Leu Asp Lys Asp Asn Asn 
            340                 345                 350         


Phe Leu Ser Asp Lys Lys Asp Lys Leu Arg Tyr Ile Ala Ala Leu Arg 
        355                 360                 365             


Gly Glu Gly Ile Lys Trp Glu Glu Val Lys Asp Arg Tyr Lys Trp Lys 
    370                 375                 380                 


Glu Leu Thr Gln Leu Ile Asn Ile Glu Glu Ile Asp Ser Thr Asp Ile 
385                 390                 395                 400 


Ala Lys Arg Lys Gln His Leu Ala Glu Cys Phe Tyr Thr His His Gly 
                405                 410                 415     


Arg Ile Phe Gly Asp Ile Gln Asn Ser Lys Ile Glu Asp Lys Asp Cys 
            420                 425                 430         


Phe Leu Tyr His Ser Leu Val Lys Glu Ile Leu Phe Glu Cys Ile Glu 
        435                 440                 445             


Lys Lys Gln Asp Phe Leu Asn Asp Thr Glu Val His Gln Arg Leu Ile 
    450                 455                 460                 


Tyr Lys Glu Asn Asn Arg Ile Met Ala Thr Ala Val Ser Ile Gly Lys 
465                 470                 475                 480 


Leu Ile His Tyr Gln Gly Gly Ile Glu Ala Ile Gly Asn Lys Glu Asp 
                485                 490                 495     


Leu Val Asn Ser Lys Phe Leu Thr Asp Ala Gly Leu Thr Glu Ile Lys 
            500                 505                 510         


Gln Asn Glu Ser Phe Val Arg Gln Trp Leu Glu Leu Ile Ala Ile Ala 
        515                 520                 525             


Asn Thr Thr Leu Ser Gln Leu Val Asp Pro Asp Gly Lys His Glu Asp 
    530                 535                 540                 


Ile Phe Ala Ala Thr Ser Phe Asp Asp Ala Leu Lys Gly Leu Asn Asn 
545                 550                 555                 560 


Ile Ser Asp Phe Asp Ser Lys Phe Lys Leu Leu Phe Gly Glu Asn His 
                565                 570                 575     


Arg Leu Tyr Asp Asp Asp Thr Glu Arg Gln Lys Leu Leu Arg Ile Ile 
            580                 585                 590         


Tyr Asp Thr Ile Ser Ala Leu Arg Asn Ala Ser Phe His Phe Lys Asn 
        595                 600                 605             


Ile Gln Gly Phe Asn Lys Ala Leu Glu Asp Asn Leu Ser Thr Lys Gly 
    610                 615                 620                 


Arg Arg Gln Lys Gly Val Val Asp Lys Ile Ile Glu Tyr Thr Lys Val 
625                 630                 635                 640 


His Gln Gln Lys Gln His Glu Leu Leu Ile Ala Asp Leu Lys Ala Ala 
                645                 650                 655     


Asn Val Glu Asp Tyr Leu Ser Gln Leu Gln Leu Asp Tyr Leu Phe Glu 
            660                 665                 670         


Val Val Cys Lys Gly Glu Arg Glu Leu Leu Asp Met Pro Lys Phe Ser 
        675                 680                 685             


Lys Leu Leu Leu Arg Ala Gly Glu Ile Gly Glu Lys Ile Ile Ser Pro 
    690                 695                 700                 


Val Asn Ala Thr Ala Met Glu His Pro Ala Tyr Gln Cys Cys Phe Ile 
705                 710                 715                 720 


Ser Leu Lys Met Leu Tyr Asp Gln Asp Phe Val Asn Trp Leu Lys Lys 
                725                 730                 735     


Gln Ser Asn Lys Asn Ile Ala Ser Trp Met Asp Ser Ala Lys Thr Arg 
            740                 745                 750         


Ala Thr Asn Ala Ala Lys Lys Ile Phe Arg Asn Gly Thr Asn Ile Ser 
        755                 760                 765             


Ser Lys Met Ala Arg Leu Arg Asn Ile Val Glu Asp Glu Thr Leu Val 
    770                 775                 780                 


Glu Tyr Phe Ser Phe Ile Thr Ala Glu Thr Ala Asn Glu Phe Gln Val 
785                 790                 795                 800 


Gln Gln Gln Lys Asn Arg Tyr Gln Ser Asn Ser Ala Ser Ala Lys Glu 
                805                 810                 815     


Gln Ser Asn Phe Val Glu Gln Phe Lys Gln Asp Phe Leu Ile Tyr Ala 
            820                 825                 830         


Phe Lys Gly Tyr Ile Gly Asp Ile Lys Phe Gly Lys Leu Asp Gln Gly 
        835                 840                 845             


Glu Lys Leu Leu Lys Cys Asn Ala Lys Gly Ser Leu Leu Pro Glu Asn 
    850                 855                 860                 


Asn Arg Ser Asp Thr Gly Ala Glu Asp Ile Glu Arg Pro Trp Leu Tyr 
865                 870                 875                 880 


Leu Val Leu His Leu Val Pro Ile Glu Val Val Asn Arg Ile Thr Leu 
                885                 890                 895     


Gln Ile Lys Lys His Ser Val Leu Thr Asn Ser Thr Leu Asp Asp Thr 
            900                 905                 910         


Arg Ala Ala Tyr Thr Asp Ile His Gln Ala Phe Ser Leu Tyr Leu Gly 
        915                 920                 925             


Val His Gly Ala Ile Leu Gly Leu Gln Ser Leu Ser Asn Glu Pro Glu 
    930                 935                 940                 


Leu Gln Val Phe Phe Glu Lys Glu Ser Asp Phe Asn Asn Leu Phe Thr 
945                 950                 955                 960 


Asp Asn Gly Glu Gly Leu Val Pro Val Lys Gly Leu Arg Asp Ile Leu 
                965                 970                 975     


Arg Phe Gly Asn Leu Glu Gln Leu Lys Lys Met Phe Ser Asp Lys Lys 
            980                 985                 990         


Val Ala Ser Asp Asp Ile Thr Asn  Leu Lys Glu Tyr Leu  Glu Ala Thr 
        995                 1000                 1005             


Gly Gly  Lys Ser Lys Ile Ala  Arg Ala Gln Glu Lys  Arg Ile Glu 
    1010                 1015                 1020             


Leu His  Lys Thr Leu Thr Glu  Leu Pro Lys Arg Leu  Thr Lys Pro 
    1025                 1030                 1035             


Arg Val  Lys Gln Thr Gly Ile  Asp Thr Tyr Glu Lys  Asn Asn Asn 
    1040                 1045                 1050             


Ile Ser  Ile Ser Gly Ser Ile  Ser Glu Tyr Arg Lys  Asp Leu Lys 
    1055                 1060                 1065             


Cys Ile  Val Ser Tyr Arg Glu  Leu Lys Asn Lys Ile  Tyr Leu Tyr 
    1070                 1075                 1080             


Asn Val  Lys Gln Ala His Gln  Leu Ile Met Ala Thr  Gln Ala Arg 
    1085                 1090                 1095             


Leu Leu  Gly Tyr Ser Gln Ile  Arg Glu Arg Asp Leu  Tyr Phe Val 
    1100                 1105                 1110             


Leu Leu  Thr Gln Leu Met Leu  Arg Gly Val Thr Leu  Glu Lys Glu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Asp Lys Asp  Lys Leu Asn Ala Leu  Asp Thr Asp 
    1130                 1135                 1140             


Thr Val  Leu Asp Glu Glu Glu  Lys Lys Lys Leu Glu  Lys Gln Ile 
    1145                 1150                 1155             


Lys Pro  Glu Arg Ser Leu Lys  Asp Leu Val Glu Lys  Gly Leu Ile 
    1160                 1165                 1170             


Phe Leu  Ala Leu Asp Gln Leu  Ser Ser Ser Asp Lys  Asp Leu Lys 
    1175                 1180                 1185             


Ala Ile  His Ser Glu Ile Glu  Asp Met Phe Val Gly  Val Ser Pro 
    1190                 1195                 1200             


Asp Ser  Asp Asn Arg Asn Leu  Arg Asn Arg Leu Ala  His Phe Lys 
    1205                 1210                 1215             


Asp Leu  Gly Asn Lys Asn Leu  Ile Asn Ile Thr Ser  Gln Ile Asn 
    1220                 1225                 1230             


Glu Val  Arg Lys Met Met Ser  Tyr Asp Arg Lys Leu  Lys Asn Ala 
    1235                 1240                 1245             


Val Ser  Lys Ser Met Ile Asp  Leu Phe Glu Arg Tyr  Asn Leu Ile 
    1250                 1255                 1260             


Leu Ser  Phe Lys Val Gln Ser  His Lys Leu Gln Leu  Lys Asn Leu 
    1265                 1270                 1275             


Lys Ser  Lys Gln Ile Thr His  Leu Asn Asn Lys Gly  Ile Thr Glu 
    1280                 1285                 1290             


Asn Leu  Leu Ser Asp Asp Tyr  Val Ser Val Ile Lys  Arg Leu Leu 
    1295                 1300                 1305             


Leu Thr  Glu Gln Asn Pro Glu  
    1310                 1315 


<210>  752
<211>  1229
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  752

Met Lys Ile Ser Lys Val Asp His Ile Lys Ser Ala Ile Ser Val Asp 
1               5                   10                  15      


Lys Asp Ser Gln Lys Gly Ile Leu Tyr Lys Asn Pro Asn Asp Gly Lys 
            20                  25                  30          


Asn Val Ala Asp Ile Gly Arg His Ile Asp Lys Leu Val Asp Lys Ala 
        35                  40                  45              


Glu Arg Gly Phe Gly Ser Lys Phe Lys Tyr Ser Val Ser Asp Ser Leu 
    50                  55                  60                  


Ser Lys Glu Asp Lys Glu Lys Ala Gln Gln Lys Lys Asp Arg Phe Lys 
65                  70                  75                  80  


Glu Asn Val Lys Lys Ser Ile Glu Asn Gln Asn Met Leu Ile Gln Pro 
                85                  90                  95      


Val Gln Ile Asp Asp Glu Phe Val Leu Ala Leu Ser Met Val Gln Gly 
            100                 105                 110         


Gly Glu Gly Ala Asn Val Leu Ser Arg Lys Ala Arg Glu Lys Ser Ala 
        115                 120                 125             


Phe Ser Arg Phe Leu Phe Asp Tyr Ala Asn Leu Asp Glu Glu Tyr Arg 
    130                 135                 140                 


Met Asp Lys Leu Arg Arg Ile Arg Arg Ile Val Leu Val Tyr Phe Tyr 
145                 150                 155                 160 


Gly Pro Asp Ala Leu Asp Asp Glu Ile Lys Gly Ala Phe Ser Val Trp 
                165                 170                 175     


Asp Asp His Lys Lys Arg Gln Gly Asp Thr Ala Lys Phe Ile Glu His 
            180                 185                 190         


Thr Phe Leu Glu Gln Lys Gln Lys Pro Asp Lys Lys Glu Glu Thr Gln 
        195                 200                 205             


Asn Tyr Lys Leu Leu Ala Asp Thr Ile Arg Asn Thr Asn Ile Lys Ser 
    210                 215                 220                 


Tyr Arg Ala Thr Asp Asp Phe Val Lys Ala Ala Met Ser Glu Glu Gly 
225                 230                 235                 240 


Asn Asp Leu Phe Phe Asp Asp Ala Asp Leu Asn Ala Phe Trp Ile Tyr 
                245                 250                 255     


His Ile Glu Ser Glu Val Glu Arg Ile Tyr Ala Lys Ile Lys Arg Leu 
            260                 265                 270         


Asn Arg Asn Asn Thr Tyr Lys Leu Gly Arg Gly Tyr Ile Cys Glu Lys 
        275                 280                 285             


Val Trp Lys Gly Ile Ile Asn Tyr Ile Cys Ile Lys Tyr Ile Ala Ile 
    290                 295                 300                 


Gly Lys Ala Val Phe Asn Val Ala Met Glu Asp Val Thr Ser Glu Gly 
305                 310                 315                 320 


Asp Glu Asn Leu Gly Val Val Ala Glu Pro Tyr Met Lys Gly Ile Ser 
                325                 330                 335     


Ser Phe Asp Tyr Glu Val Ile Lys Ala Glu Glu Arg Leu Gln Arg Glu 
            340                 345                 350         


Thr Ala Val Tyr Thr Thr Phe Ala Ile Asn Ser Phe Leu Thr Ala Thr 
        355                 360                 365             


Val Glu Ile Asp Asn Lys His Tyr Asp Ile Ser Asp Lys Glu Leu Lys 
    370                 375                 380                 


Ile Leu Pro Tyr Ala Lys Arg Asn Ile Leu Gln Tyr Tyr Gly Gly Gln 
385                 390                 395                 400 


Ser Arg Trp Asn Asp Phe Asp Phe Asp Ser Met Ser Glu Gly Asp Ser 
                405                 410                 415     


Asp Lys Tyr Leu Trp Ser Gln Ile Lys Ser Ile Leu Glu Ser Met Arg 
            420                 425                 430         


Asn Glu Ser Phe His Phe Lys Thr Glu Asn Tyr Arg Cys Asp Trp Asp 
        435                 440                 445             


Lys Asn Leu Ile Ser Glu Met Phe Lys Ala Asp Ser Lys Ala Cys Gly 
    450                 455                 460                 


Lys Thr Glu Val Thr Arg Phe Tyr Ser Asn Asn Ile Pro Met Phe Tyr 
465                 470                 475                 480 


Ala Val Lys Asp Ile Glu Lys Leu Met Tyr Lys Leu Tyr Asp Glu Tyr 
                485                 490                 495     


Thr Val Arg Val Ser Gln Val Pro Ala Phe Asn Thr Val Phe Val Arg 
            500                 505                 510         


Lys Asn Phe Pro Asp Phe Ile Lys Asn Glu Met His Ile Asn Thr Ser 
        515                 520                 525             


Phe Ser Leu Asp Asp Thr Val Lys Tyr Gln Ser Ala Leu Tyr Tyr Leu 
    530                 535                 540                 


Leu Lys Glu Ile Tyr Tyr Asn Leu Phe Leu Thr Asp Lys Ala Ser Lys 
545                 550                 555                 560 


Ser Glu Phe Leu Ser Ala Val Arg Asn Met Lys Gly Ala Asp Lys Lys 
                565                 570                 575     


Gln Val Phe Ala Thr Arg Asp Phe Gln Ala Arg Ile Lys Glu Ile Asn 
            580                 585                 590         


Glu Ser Arg Asp Tyr Thr Leu Ser Glu Ile Cys Gln Leu Ile Met Thr 
        595                 600                 605             


Glu Tyr Asn Gln Gln Asn Asp Lys Trp Met Lys Lys Lys Thr Asn Thr 
    610                 615                 620                 


Ala Gln Lys Lys Arg Pro Asp Gly Tyr Gln His Tyr Lys Ala Leu Leu 
625                 630                 635                 640 


Leu Glu Gly Leu Arg Lys Ala Phe Leu Ser Tyr Ile Asp Lys Asp Glu 
                645                 650                 655     


Gln Leu Phe Gly Phe Ile Lys Lys Pro Leu Leu Arg Glu Lys Leu Ala 
            660                 665                 670         


Glu Asn Asp Phe Leu Pro Asn Phe Ser Thr Lys Arg Tyr Asn Glu Leu 
        675                 680                 685             


Ile Glu Glu Leu Glu Thr Glu Ala Glu Leu Gln Lys Trp Tyr Val Thr 
    690                 695                 700                 


Gly Arg Leu Leu Thr Pro Lys Gln Val Asn His Leu Ser Gly Cys Phe 
705                 710                 715                 720 


Lys Asn Tyr Ile Gln Tyr Lys Trp Asp Ile Glu Arg Arg Ser Glu Ser 
                725                 730                 735     


Thr Gly Asn Arg Leu Thr Val Ser Cys Glu Glu Val Ile Leu Tyr Lys 
            740                 745                 750         


Lys Ile Leu Gln Val Leu Glu Ile Cys Thr Lys Leu Ser Gly Cys Ile 
        755                 760                 765             


Ser Asn Met Val Ser Asp Tyr Phe Glu Asp Glu Asp Asp Tyr Ala Arg 
    770                 775                 780                 


Tyr Leu Ala Gly Phe Leu Asp Tyr Glu Ser Ser Leu Gly Asp Tyr Ser 
785                 790                 795                 800 


Val Ser Pro Ser Gly Lys Leu Lys Asp Phe Cys Arg Thr Ser Val Asp 
                805                 810                 815     


Ser Ser Asp Asp Thr Val Ser Ile Tyr Tyr Asp Gly Glu Asn Pro Ile 
            820                 825                 830         


Leu Gln Arg Asn Ile Val Leu Ala Lys Leu Tyr Gly Asn Gly Gln Ile 
        835                 840                 845             


Ile Ser Asp Val Leu Lys Asp Asn Lys Val Ser Leu Glu Asp Ile Lys 
    850                 855                 860                 


Glu Phe Tyr Arg Ser Lys Asp Lys Leu Thr Ala Tyr Asn Thr Thr Gly 
865                 870                 875                 880 


Thr Tyr Asn Ser Ile Asp Glu Leu Lys Glu Ile Lys Lys Tyr Gln Glu 
                885                 890                 895     


Leu Lys Asn His Val Glu Phe Ile Asp Ile Val Glu Tyr Thr Glu Ile 
            900                 905                 910         


Leu Asn Glu Leu Gln Gly Gln Leu Val Asn Tyr Thr Phe Leu Arg Glu 
        915                 920                 925             


Arg Asp Leu Leu Tyr Phe Gln Leu Gly Phe His Phe Ser Cys Leu Asn 
    930                 935                 940                 


Asn Asp Ser Tyr Lys Pro Ser Glu Tyr Val Arg Ile Glu Ala Cys Asp 
945                 950                 955                 960 


Lys Val Ile Ser Asn Ala Ile Leu His Gln Ile Ala Ser Leu Tyr Ile 
                965                 970                 975     


Asn Gly Ile Ser Leu Tyr Ile Lys Asp Glu Ala Gly Thr Tyr Val Lys 
            980                 985                 990         


Asp Lys Asp Lys Ser Ala Gly Gly  Asn Ile Ser Asp Phe  Phe Lys Tyr 
        995                 1000                 1005             


Cys Lys  Asn Thr Phe Thr Glu  Tyr Ser Asp Ser Gln  Thr Val Tyr 
    1010                 1015                 1020             


Asn Ala  Gly Leu Glu Leu Phe  Glu Asn Leu Asp Glu  His Lys Gln 
    1025                 1030                 1035             


Ile Ile  Asp Leu Arg Asn Tyr  Ile Asp His Phe Lys  Tyr Tyr Ile 
    1040                 1045                 1050             


Ser Asp  Lys Ser Val Asn Ser  Gly Arg Ser Leu Ile  Asp Ile Tyr 
    1055                 1060                 1065             


Ser Glu  Val Phe Asp Arg Phe  Phe Thr Tyr Asp Leu  Lys Tyr His 
    1070                 1075                 1080             


Lys Asn  Ile Pro Asn Thr Leu  Tyr Asn Ile Leu Met  Gly His Phe 
    1085                 1090                 1095             


Ile Glu  Thr Asn Phe Asp Phe  Ser Thr Gly Thr Lys  Asp Ile Glu 
    1100                 1105                 1110             


Lys Asp  Lys Lys Leu Val Lys  Lys Asn Arg Ala Ser  Leu Lys Ile 
    1115                 1120                 1125             


Ile Lys  Ala Ser Ser Glu Pro  Phe Thr Tyr Lys Val  Gln Gly Lys 
    1130                 1135                 1140             


Lys Val  Glu Cys Pro Ala Lys  Ser Glu Lys Phe Leu  Arg Asn Val 
    1145                 1150                 1155             


Ile Ser  Leu Leu Tyr Tyr Arg  Glu Ser Asn Thr Pro  Asp Ile Ile 
    1160                 1165                 1170             


Tyr Arg  Glu Gly Thr Ile Lys  Asn Ala Glu Pro Asp  Asn Lys Gly 
    1175                 1180                 1185             


Lys Asn  Gly Ile Lys Asn Lys  Leu Asp Lys Ser Lys  Asn His Lys 
    1190                 1195                 1200             


Gln Glu  Arg Asn Asn Asn His  Lys Thr Glu Lys Leu  Ser Ser Asn 
    1205                 1210                 1215             


Pro Phe  Asp Ser Leu Leu Asp  Asp Phe Leu Leu 
    1220                 1225                 


<210>  753
<211>  1210
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  753

Met Lys Ile Thr Lys Arg Lys Trp Glu Asp Val Pro Pro Leu Phe Phe 
1               5                   10                  15      


His Arg Asp Lys Asp Ser Gly Arg Leu Ile Arg Gln Asp Asp Arg Glu 
            20                  25                  30          


His Asp Tyr Thr Asp Glu Leu Phe Arg Lys Thr Thr Val Asp Ser Ile 
        35                  40                  45              


Phe Ile Arg Ser Leu Gln Asn Arg Leu Leu Arg Ser Gln Asp Lys Glu 
    50                  55                  60                  


Gly Asn Lys Ile Gly Arg Asn Glu Ile Thr Glu Leu Val Glu Asn Leu 
65                  70                  75                  80  


Cys Lys Gly Ala Glu Ile Gln Lys Ser Ile Asp Glu Ile Lys Asp Ser 
                85                  90                  95      


Lys Ser Asn Val Lys Ala Leu Cys Asp Lys Thr Leu Thr Asp Tyr Gly 
            100                 105                 110         


Lys Ser Phe Ala Ala Glu Glu Gly Arg Thr Thr Leu Tyr Glu Ala Ile 
        115                 120                 125             


Leu Asn Leu Ala Lys Gly Asn Ala Ile Gln Lys Ala Met Ala Glu Ala 
    130                 135                 140                 


Glu Leu Lys Gln Ile His Glu Ala Leu Lys Lys Glu Lys Glu Asp Arg 
145                 150                 155                 160 


Ile Asn Arg Val Gln Asn Ser Ile Lys Asn Asn Lys Ile Pro Leu Lys 
                165                 170                 175     


Val Asn Glu Asp Gly Thr Ile Ser Ala Asn Asn Asp Arg Ala Ser Trp 
            180                 185                 190         


Leu Leu Glu Leu Leu Lys Pro Val Ala Ser Glu His Asp Lys Gly Asp 
        195                 200                 205             


Arg Tyr Pro Val Leu Thr Glu Met Glu Gly Ile Val Ser Phe Asp Lys 
    210                 215                 220                 


Leu Cys Glu Glu Val Arg Asn Lys Ile His Gly Arg Lys Gly Arg Thr 
225                 230                 235                 240 


Arg Ser Ile Ala Met Ser Val Asp Glu Ala Val Lys Glu Tyr Leu Lys 
                245                 250                 255     


Glu Leu Trp Lys Lys His Ala Asp Arg His Arg Asp Met Arg Tyr Tyr 
            260                 265                 270         


Phe Gln Ala Val Lys Glu Tyr Phe Lys Glu Asn Phe Pro Ile Arg Thr 
        275                 280                 285             


Lys Gln Lys Gly Ala Gly Ile Arg Gln Ser Leu Leu Lys Glu Asp Thr 
    290                 295                 300                 


Val Val Ala Arg Leu Leu Asp Pro Lys His Met Ala Lys Ala Val Arg 
305                 310                 315                 320 


Arg Lys Leu Ile Asn Gln Ser Ile Gln Met His Ile Leu Tyr Gly Lys 
                325                 330                 335     


Leu Tyr Glu Tyr Cys Cys Arg Glu Asp Arg Asn Leu Pro Val Asn Ser 
            340                 345                 350         


Glu Thr Leu Gln Leu Ile Gln Val Leu Glu Ala Phe Lys Lys Gln Leu 
        355                 360                 365             


Met Thr Ala Val Leu Trp Ser Val Ser Arg Leu Cys Tyr Phe Tyr Glu 
    370                 375                 380                 


Phe Tyr Ser Gly Asp Ile Leu Leu Ala Glu Glu Tyr Arg Arg Asp Phe 
385                 390                 395                 400 


Leu Asn Gln Lys Asn Asp His Lys Asp Ile Gln Ala Cys Lys Glu Lys 
                405                 410                 415     


Leu Gln Asp Phe Phe Pro Leu Ala Glu Leu Gln Glu Lys Ile Arg Glu 
            420                 425                 430         


Cys Ala Asp Lys Asp Ile Asn Asn Ile Lys Asp Lys Ile Thr Asn Asp 
        435                 440                 445             


Val Leu Ala Cys Asn Asn Leu Leu Glu Glu Cys Val Phe Cys Ile Ser 
    450                 455                 460                 


Lys Leu Arg Asn Asn Ile Phe His Tyr Lys Asn Leu Ser Phe Thr Gln 
465                 470                 475                 480 


Ala Leu Lys His Ile Ala Asn Glu Asn Lys Glu Glu Asp Ile Pro Ile 
                485                 490                 495     


Ile Leu Arg Leu Tyr Lys Gln Asp Cys Glu Asn Val Asn Lys Ala Phe 
            500                 505                 510         


Ala Asn Arg Ile Ser Ser Met Asn Leu Pro Leu Tyr Tyr Ser Thr Glu 
        515                 520                 525             


Phe Leu Leu Arg Ile Phe Lys Lys Gln Gly Ala Glu Leu Ser Leu Tyr 
    530                 535                 540                 


Ser Thr Lys Asn Gln Met Thr Pro Ser Phe Lys Arg Val Tyr Glu Arg 
545                 550                 555                 560 


Gly Lys Asn Leu Arg Leu Glu Tyr Glu Arg Glu Pro Met Arg Ser Asn 
                565                 570                 575     


Ile Ala Asn Glu Tyr Asp Lys Asp Pro Gln Ser Asp Tyr Trp Met Arg 
            580                 585                 590         


Trp Phe Ser Gln Phe Ala Thr Gly Thr Val Asp Thr Asn Ala Gly Ile 
        595                 600                 605             


Lys Gly Glu Met Glu Asp Tyr Pro His Ala Ser Val Asn Leu Gly Ile 
    610                 615                 620                 


Glu Ile Glu Ala Gly Thr Asn Ile Asp Ala Gln Arg Ala Met Arg Asn 
625                 630                 635                 640 


Leu Leu Gln Leu Ile Tyr Lys His His Phe Leu Pro Glu Val Gln Lys 
                645                 650                 655     


Asp Glu Thr Val Val Thr Asp Val Ile Pro Lys Val Leu Glu Arg Asn 
            660                 665                 670         


Arg Lys Leu Ser Glu Val Arg Asn Arg Ser Asp Lys Thr Tyr Gly Tyr 
        675                 680                 685             


Lys Glu Ile Glu Glu Leu Cys Lys Lys Asn Lys Gly Lys Lys Asp Ser 
    690                 695                 700                 


Leu Ser Glu Leu Met Lys Asp Leu Gln Arg Lys Val Ser Glu Thr Glu 
705                 710                 715                 720 


Lys Glu Lys Arg Glu Leu Ala Arg Glu Lys Thr Asp Tyr Ala Gln Arg 
                725                 730                 735     


Phe Ile Leu Asp Ile Phe Ala Glu Ala Phe Cys Asn Phe Met Asp Glu 
            740                 745                 750         


Arg Tyr Glu Asp Glu Tyr Gln Glu Ile Met Ser Pro Ile Lys Asn Glu 
        755                 760                 765             


Glu Glu Ala Lys Lys Trp Thr Glu Met Phe Thr Asp Lys Ala Asp Lys 
    770                 775                 780                 


Asp Asn Lys Asp Lys Leu Leu Val Leu Lys Thr Ser Phe Asp Lys Asp 
785                 790                 795                 800 


Asn Val Glu Lys Tyr Leu Leu Ala Leu Tyr Pro Leu Met Arg Leu Leu 
                805                 810                 815     


Asp Asp Lys Glu Leu Ser Glu Leu Gln Gln Gln Met Leu Arg Phe Arg 
            820                 825                 830         


Ala Ser Val Ser Gly Trp Gln Gly Gly Thr Asp Phe Ser Glu Asp Ile 
        835                 840                 845             


Ala Met Ala Glu Lys Ile Glu Glu Leu Ala Glu Leu Val Lys Leu Thr 
    850                 855                 860                 


Glu Pro Glu Ser Gln Tyr Ala Glu Glu Ala Trp Lys Asn Arg Ala Ile 
865                 870                 875                 880 


Gly Val Phe Glu Gln Phe Val Glu Gly Lys Met Ala Glu Tyr Gly Thr 
                885                 890                 895     


Phe Tyr Ile Gln Asn Asp Ser Leu Thr Gln Val Pro Arg Gly Asn Met 
            900                 905                 910         


Arg Lys Leu Leu Arg Ser Gly Val Ile Gly Val Tyr Asn Lys Val Leu 
        915                 920                 925             


Ala Ser Cys Lys Gln Ala Thr Lys Ala Asp Tyr Gly Ala Tyr Ser Gly 
    930                 935                 940                 


Asp His Trp Ser Ile Glu Asp Pro Asp Gly Asn Pro Ile Lys Ser Ala 
945                 950                 955                 960 


Glu Gln Ala Gln Ala Leu Leu Gln Arg Leu His Lys Lys Tyr Thr Glu 
                965                 970                 975     


Ser Pro Ser Gln Phe Ser Asp Asp Asp His Lys Leu Tyr Asp Lys Thr 
            980                 985                 990         


Leu Arg Gln Leu Asp Ala Tyr Asn  Arg Ala Met Lys Asn  Leu Ser Phe 
        995                 1000                 1005             


Gly Ser  Leu Tyr Glu Ile Cys  Arg Ile His Met Glu  Thr Leu Ser 
    1010                 1015                 1020             


Arg Trp  Val Gly Phe Val Gln  Asp Trp Glu Arg Asp  Met Tyr Phe 
    1025                 1030                 1035             


Leu Leu  Leu Ala Trp Thr Lys  Gln Gly Lys Leu Leu  Asn Val Thr 
    1040                 1045                 1050             


Glu Thr  Asp Val Ile Glu Ile  Phe Glu Lys Gly Ser  Val Ile Tyr 
    1055                 1060                 1065             


Lys Met  Asn Lys Lys Leu Lys  Asn Gly Asp Arg Tyr  Ala Phe Thr 
    1070                 1075                 1080             


Ser Ile  Tyr Arg Asn Asn Asn  Asp Glu Lys Leu Glu  Phe Leu Gln 
    1085                 1090                 1095             


Ile Arg  Asn Phe Ile Ala His  Leu His Leu Leu Arg  Lys Ser Glu 
    1100                 1105                 1110             


Trp Lys  Gly Asp Lys Lys Ala  Gly Tyr Ser Val Ile  Glu Asp Tyr 
    1115                 1120                 1125             


Ile Asn  Lys Leu Arg Phe Leu  Leu Ser Tyr Asp Gln  Lys Arg Met 
    1130                 1135                 1140             


Asn Ala  Val Thr Lys Ala Met  Gln Gln Ile Phe Glu  Lys His Lys 
    1145                 1150                 1155             


Val Ile  Val Lys Phe Met Val  Glu Lys Gly Gly Met  Leu Lys Val 
    1160                 1165                 1170             


Lys Asp  Val Lys Pro Gly Ile  Ile Glu His Leu Lys  Gln Thr Lys 
    1175                 1180                 1185             


Arg Ile  Glu Ile Pro Cys His  Gly Glu Arg Phe Thr  Asp Ser Leu 
    1190                 1195                 1200             


Leu Val  Leu Met Lys Tyr Gln  
    1205                 1210 


<210>  754
<211>  1210
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  754

Met Lys Ile Thr Lys Arg Lys Trp Glu Asp Val Pro Pro Leu Phe Phe 
1               5                   10                  15      


His Arg Asp Lys Asp Ser Gly Arg Leu Ile Arg Gln Asp Asp Arg Glu 
            20                  25                  30          


His Asp Tyr Thr Asp Glu Leu Phe Arg Lys Thr Thr Val Asp Ser Ile 
        35                  40                  45              


Phe Ile Arg Ser Leu Gln Asn Arg Leu Leu Arg Ser Gln Asp Lys Glu 
    50                  55                  60                  


Gly Asn Lys Ile Gly Arg Asn Glu Ile Thr Glu Leu Val Glu Asn Leu 
65                  70                  75                  80  


Cys Lys Gly Ala Glu Ile Gln Lys Ser Ile Asp Glu Ile Lys Asp Ser 
                85                  90                  95      


Lys Ser Asn Val Lys Ala Leu Cys Asp Lys Thr Leu Thr Asp Tyr Gly 
            100                 105                 110         


Lys Ser Phe Ala Ala Glu Glu Gly Arg Thr Thr Leu Tyr Glu Ala Ile 
        115                 120                 125             


Leu Asn Leu Ala Lys Gly Asn Ala Ile Gln Lys Ala Met Ala Glu Ala 
    130                 135                 140                 


Glu Leu Lys Gln Ile His Glu Ala Leu Lys Lys Glu Lys Glu Asp Arg 
145                 150                 155                 160 


Ile Asn Arg Val Gln Asn Ser Ile Lys Asn Asn Lys Ile Pro Leu Lys 
                165                 170                 175     


Val Asn Glu Asp Gly Thr Ile Ser Ala Asn Asn Asp Arg Ala Ser Trp 
            180                 185                 190         


Leu Leu Glu Leu Leu Lys Pro Val Ala Ser Glu His Asp Lys Gly Asp 
        195                 200                 205             


Arg Tyr Pro Val Leu Thr Glu Met Glu Gly Ile Val Ser Phe Asp Lys 
    210                 215                 220                 


Leu Cys Glu Glu Val Arg Asn Lys Ile His Gly Arg Lys Gly Arg Thr 
225                 230                 235                 240 


Arg Ser Ile Ala Met Ser Val Asp Glu Ala Val Lys Glu Tyr Leu Lys 
                245                 250                 255     


Glu Leu Trp Lys Lys His Ala Asp Arg His Arg Asp Met Arg Tyr Tyr 
            260                 265                 270         


Phe Gln Ala Val Lys Glu Tyr Phe Lys Glu Asn Phe Pro Ile Arg Thr 
        275                 280                 285             


Lys Gln Lys Gly Ala Gly Ile Arg Gln Ser Leu Leu Lys Glu Asp Thr 
    290                 295                 300                 


Val Val Ala Arg Leu Leu Asp Pro Lys His Met Ala Lys Ala Val Arg 
305                 310                 315                 320 


Arg Lys Leu Ile Asn Gln Ser Ile Gln Met His Ile Leu Tyr Gly Lys 
                325                 330                 335     


Leu Tyr Glu Tyr Cys Cys Arg Glu Asp Arg Asn Leu Pro Val Asn Ser 
            340                 345                 350         


Glu Thr Leu Gln Leu Ile Gln Val Leu Glu Ala Phe Lys Lys Gln Leu 
        355                 360                 365             


Met Thr Ala Val Leu Trp Ser Val Ser Arg Leu Cys Tyr Phe Tyr Glu 
    370                 375                 380                 


Phe Tyr Ser Gly Asp Ile Leu Leu Ala Glu Glu Tyr Arg Arg Asp Phe 
385                 390                 395                 400 


Leu Asn Gln Lys Asn Asp His Lys Asp Ile Gln Ala Cys Lys Glu Lys 
                405                 410                 415     


Leu Gln Asp Phe Phe Pro Leu Ala Glu Leu Gln Glu Lys Ile Arg Glu 
            420                 425                 430         


Cys Ala Asp Lys Asp Ile Asn Asn Ile Lys Asp Lys Ile Thr Asn Asp 
        435                 440                 445             


Val Leu Ala Cys Asn Asn Leu Leu Glu Glu Cys Val Phe Cys Ile Ser 
    450                 455                 460                 


Lys Leu Arg Asn Asn Ile Phe His Tyr Lys Asn Leu Ser Phe Thr Gln 
465                 470                 475                 480 


Ala Leu Lys His Ile Ala Asn Glu Asn Lys Glu Glu Asp Ile Pro Ile 
                485                 490                 495     


Ile Leu Arg Leu Tyr Lys Gln Asp Cys Glu Asn Val Asn Lys Ala Phe 
            500                 505                 510         


Ala Asn Arg Ile Ser Ser Met Asn Leu Pro Leu Tyr Tyr Ser Thr Glu 
        515                 520                 525             


Phe Leu Leu Arg Ile Phe Lys Lys Gln Gly Ala Glu Leu Ser Leu Tyr 
    530                 535                 540                 


Ser Thr Lys Asn Gln Met Thr Pro Ser Phe Lys Arg Val Tyr Glu Arg 
545                 550                 555                 560 


Gly Lys Asn Leu Arg Leu Glu Tyr Glu Arg Glu Pro Met Arg Ser Asn 
                565                 570                 575     


Ile Ala Asn Glu Tyr Asp Lys Asp Pro Gln Ser Asp Tyr Trp Met Arg 
            580                 585                 590         


Trp Phe Ser Gln Phe Ala Thr Gly Thr Val Asp Thr Asn Ala Gly Ile 
        595                 600                 605             


Lys Gly Glu Met Glu Asp Tyr Pro His Ala Ser Val Asn Leu Gly Ile 
    610                 615                 620                 


Glu Ile Glu Ala Gly Thr Asn Ile Asp Ala Gln Arg Ala Met Arg Asn 
625                 630                 635                 640 


Leu Leu Gln Leu Ile Tyr Lys His His Phe Leu Pro Glu Val Gln Lys 
                645                 650                 655     


Asp Glu Thr Val Val Thr Asp Val Ile Pro Lys Val Leu Glu Arg Asn 
            660                 665                 670         


Arg Lys Leu Ser Glu Val Arg Asn Arg Ser Asp Lys Thr Tyr Gly Tyr 
        675                 680                 685             


Lys Glu Ile Glu Glu Leu Cys Lys Lys Asn Lys Gly Lys Lys Asp Ser 
    690                 695                 700                 


Leu Ser Glu Leu Met Lys Asp Leu Gln Arg Lys Val Ser Glu Thr Glu 
705                 710                 715                 720 


Lys Glu Lys Arg Glu Leu Ala Arg Glu Lys Thr Asp Tyr Ala Gln Arg 
                725                 730                 735     


Phe Ile Leu Asp Ile Phe Ala Glu Ala Phe Cys Asn Phe Met Asp Glu 
            740                 745                 750         


Arg Tyr Glu Asp Glu Tyr Gln Glu Ile Met Ser Pro Ile Lys Asn Glu 
        755                 760                 765             


Glu Glu Ala Lys Lys Trp Thr Glu Met Phe Thr Asp Lys Ala Asp Lys 
    770                 775                 780                 


Asp Asn Lys Asp Lys Leu Leu Val Leu Lys Thr Ser Phe Asp Lys Asp 
785                 790                 795                 800 


Asn Val Glu Lys Tyr Leu Leu Ala Leu Tyr Pro Leu Met Arg Leu Leu 
                805                 810                 815     


Asp Asp Lys Glu Leu Ser Glu Leu Gln Gln Gln Met Leu Arg Phe Arg 
            820                 825                 830         


Ala Ser Val Ser Gly Trp Gln Gly Gly Thr Asp Phe Ser Glu Asp Ile 
        835                 840                 845             


Ala Met Ala Glu Lys Ile Glu Glu Leu Ala Glu Leu Val Lys Leu Thr 
    850                 855                 860                 


Glu Pro Glu Ser Gln Tyr Ala Glu Glu Ala Trp Lys Asn Arg Ala Ile 
865                 870                 875                 880 


Gly Val Phe Glu Gln Phe Val Glu Gly Lys Met Ala Glu Tyr Gly Thr 
                885                 890                 895     


Phe Tyr Ile Gln Asn Asp Ser Leu Thr Gln Val Pro Arg Gly Asn Met 
            900                 905                 910         


Arg Lys Leu Leu Arg Ser Gly Val Ile Gly Val Tyr Asn Lys Val Leu 
        915                 920                 925             


Ala Ser Cys Lys Gln Ala Thr Lys Ala Asp Tyr Gly Ala Tyr Ser Gly 
    930                 935                 940                 


Asp His Trp Ser Ile Glu Asp Pro Asp Gly Asn Pro Ile Lys Ser Ala 
945                 950                 955                 960 


Glu Gln Ala Gln Ala Leu Leu Gln Arg Leu His Lys Lys Tyr Thr Glu 
                965                 970                 975     


Ser Pro Ser Gln Phe Ser Asp Asp Asp His Lys Leu Tyr Asp Lys Thr 
            980                 985                 990         


Leu Arg Gln Leu Asp Ala Tyr Asn  Arg Ala Met Lys Asn  Leu Ser Phe 
        995                 1000                 1005             


Gly Ser  Leu Tyr Glu Ile Cys  Arg Ile His Met Glu  Thr Leu Ser 
    1010                 1015                 1020             


Arg Trp  Val Gly Phe Val Gln  Asp Trp Glu Arg Asp  Met Tyr Phe 
    1025                 1030                 1035             


Leu Leu  Leu Ala Trp Thr Lys  Gln Gly Lys Leu Leu  Asn Val Thr 
    1040                 1045                 1050             


Glu Thr  Asp Val Ile Glu Ile  Phe Glu Lys Gly Ser  Val Ile Tyr 
    1055                 1060                 1065             


Lys Met  Asn Lys Lys Leu Lys  Asn Gly Asp Arg Tyr  Ala Phe Thr 
    1070                 1075                 1080             


Ser Ile  Tyr Arg Asn Asn Asn  Asp Glu Lys Leu Glu  Phe Leu Gln 
    1085                 1090                 1095             


Ile Arg  Asn Phe Ile Ala His  Leu His Leu Leu Arg  Lys Ser Glu 
    1100                 1105                 1110             


Trp Lys  Gly Asp Lys Lys Ala  Gly Tyr Ser Val Ile  Glu Asp Tyr 
    1115                 1120                 1125             


Ile Asn  Lys Leu Arg Phe Leu  Leu Ser Tyr Asp Gln  Lys Arg Met 
    1130                 1135                 1140             


Asn Ala  Val Thr Lys Ala Met  Gln Gln Ile Phe Glu  Lys His Lys 
    1145                 1150                 1155             


Val Ile  Val Lys Phe Met Val  Glu Lys Gly Gly Met  Leu Lys Val 
    1160                 1165                 1170             


Lys Asp  Val Lys Pro Gly Ile  Ile Glu His Leu Lys  Gln Thr Lys 
    1175                 1180                 1185             


Arg Ile  Glu Ile Pro Cys His  Gly Glu Arg Phe Thr  Asp Ser Leu 
    1190                 1195                 1200             


Leu Val  Leu Met Lys Tyr Gln  
    1205                 1210 


<210>  755
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  755

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Tyr Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  756
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  756

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Tyr Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  757
<211>  1330
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  757

Met Lys Arg Glu Lys Asn Ile Thr Ile Met Lys Ile Ser Lys Val Asn 
1               5                   10                  15      


His Arg Arg Thr Ala Val Ala Leu Asn Gly Asp Lys Ser Glu Leu Gly 
            20                  25                  30          


Gly Ile Leu Tyr Glu Ala Pro Val Gln Lys Asp Lys Asn Gly Asn Tyr 
        35                  40                  45              


Asn Asp Val Ile Ala Glu Thr Gly Lys Val Val Asn Glu Ala Leu Asp 
    50                  55                  60                  


Lys Lys Ser Arg Leu Tyr Thr Pro Phe Asn Asn Gln Lys Val Ile Ile 
65                  70                  75                  80  


Asp Lys Asn Leu Gln Arg Tyr Ala Asn Asn Leu Lys Arg Cys Tyr Ile 
                85                  90                  95      


Asn Phe Val Lys Gln Tyr Val Asn Asn Lys Ser Phe Asn Tyr Lys Ala 
            100                 105                 110         


Met Gln Phe Ile Pro Asp Ile Gln Asn Pro Lys Thr Asn Asp Ala Val 
        115                 120                 125             


Asn Tyr Arg Thr Asp Arg Asp Asn Val Tyr Asn Lys Asn Lys Tyr Tyr 
    130                 135                 140                 


Asp Lys Gln Thr Lys Ser Lys Ser Lys Lys Phe Ile Tyr Glu Lys Ile 
145                 150                 155                 160 


Val Ile Pro Gln Asn Glu Lys Asn Ile Val Ile Ser Ala Leu Val Asn 
                165                 170                 175     


Cys Ser Leu Arg Lys Ser Leu Arg Lys Asp Val Ser Tyr Lys Thr Lys 
            180                 185                 190         


Ser Gly Glu Ile Lys Thr Tyr Asn Leu Pro Glu Leu Val Lys Lys Ser 
        195                 200                 205             


Met Arg Phe Tyr Cys Leu Glu Gly Gln Arg Glu Pro Asp Glu Lys Glu 
    210                 215                 220                 


Lys Tyr Glu Met Tyr Ile Leu Phe Ser Tyr Met Lys Glu Asp Lys Arg 
225                 230                 235                 240 


Thr Lys Asn Thr Asp Leu Leu Val Lys Ser Ile Ser Asn Gln Asn Thr 
                245                 250                 255     


Lys Val Lys Val Glu Asp Ile Asp Gly Asn Lys Leu Leu Lys Leu Ser 
            260                 265                 270         


Ile Ala Asp Thr Lys Lys Lys Pro Leu Trp Glu Tyr Leu Ile Lys Tyr 
        275                 280                 285             


Ala Asp Ser Ser Arg Gln Arg Glu Leu Met Tyr Asp Ile Arg Lys Lys 
    290                 295                 300                 


Ile Ile Leu Tyr Val Ala Gly Ile Glu Glu Tyr Glu Asn Ile Lys Glu 
305                 310                 315                 320 


Asp Ser Gly Leu Ser Lys Val Ser Trp Ser Lys Tyr Asn Ile Ser Asp 
                325                 330                 335     


Asn Lys Met Phe Phe Asp Ile Asn Ser Cys Thr Asp Lys Arg Lys Gln 
            340                 345                 350         


Asn Leu Glu Ile Lys Ile Arg Glu Ala Asn Ile Glu His Tyr Arg Asn 
        355                 360                 365             


Ala Ser Ser Lys Leu Cys Asp Asp Glu Ser Ile Phe Trp Phe Gln His 
    370                 375                 380                 


Phe Glu Gly Val Ile Glu Thr Leu Phe Ser Lys Lys Ser Lys Ile Ser 
385                 390                 395                 400 


Glu Glu Arg Leu Gly Cys Ala Tyr Ile Cys Asp Tyr Leu Trp Lys Asp 
                405                 410                 415     


Phe Leu Ser Tyr Leu Ala Ala Lys Tyr Ile Asp Leu Gly Lys Gly Val 
            420                 425                 430         


Tyr His Phe Thr Met Lys Asp Lys Leu Asp Met Leu Asn Lys Asn Glu 
        435                 440                 445             


Ala Val Thr Asp Leu Arg Phe Gly Ile Val Ser Glu Lys Tyr Glu Lys 
    450                 455                 460                 


Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Glu Leu 
465                 470                 475                 480 


Asp Arg Asn Ile Ala Ala Tyr Val Thr Phe Ala Ala Asp Ile Phe Ala 
                485                 490                 495     


Lys Ser Val Ile Lys Ser Asp Tyr Arg Thr Lys Lys Asp Asn Asn Ser 
            500                 505                 510         


Asp Val Leu Gln Tyr Ser Asp Lys Glu Phe Arg Asn Ser Glu Val Ile 
        515                 520                 525             


Arg Asp Asn Ala Glu Lys Asn Ile Leu Gln Tyr Trp Gly Gly Tyr Ser 
    530                 535                 540                 


Arg Trp Gly Thr Glu Asn Ser Lys Leu Pro Glu Asn Asn Lys Val Ser 
545                 550                 555                 560 


Asp Phe Gly Lys Leu Asp Val Ser Asp Leu Cys Ile Asp Ile Lys Lys 
                565                 570                 575     


His Leu Ala Gly Ile Arg Asn Ser Ser Val His Tyr Thr Thr Lys Ile 
            580                 585                 590         


Lys Asn Glu Ser Ala Ala Asp Gly Ser Asn Val Lys Ile Leu Phe Glu 
        595                 600                 605             


Lys Asp Leu Ala Asp Ile Asn Ile Ile Tyr Ala Asp Lys Tyr Tyr Ser 
    610                 615                 620                 


Asn Asn Val Trp Met Phe Tyr Ser Leu Glu Asp Ile Asn Lys Leu Ile 
625                 630                 635                 640 


Ala Phe Leu Tyr Lys Glu Lys Arg Val Ile Arg Gln Val Gln Ile Pro 
                645                 650                 655     


Ser Phe Ser Arg Ile Leu Lys Arg Lys Ala Met Gln Asp Val Ile Asn 
            660                 665                 670         


Glu Ile Phe Lys Asp Asp Phe Asp Glu Asn Ile Val Asn Pro Glu Leu 
        675                 680                 685             


Lys Glu Lys Tyr Arg Asn Ser Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
    690                 695                 700                 


Tyr Asn Ala Phe Ile Ile Gln Pro Glu Leu Lys Glu Lys Phe Lys Asp 
705                 710                 715                 720 


Lys Ile Lys Thr Met Lys Ser Glu Leu Tyr Asn Lys Leu Lys Thr Ile 
                725                 730                 735     


Asp Lys Lys Glu Tyr Lys Ala Leu Tyr Cys Met Leu Ser Asn Glu Glu 
            740                 745                 750         


Ser Ala Leu Lys Asn Phe Ala Asp Arg Ile Tyr Ser Val Asp Gly Asp 
        755                 760                 765             


Asn Val Ser Phe Ala Asp Ile Cys Lys Ile Leu Met Thr Asp Tyr Asn 
    770                 775                 780                 


Met Gln Asn Gln Glu Lys Lys Asn Ile Glu Ser Met Glu Gln Lys Lys 
785                 790                 795                 800 


Lys Asn Lys Gly Lys Asp Glu Asn Tyr Lys His Phe Pro Leu Leu Leu 
                805                 810                 815     


His Lys Val Leu Lys Glu Leu Phe Ile Glu Tyr Leu Lys Gln Thr His 
            820                 825                 830         


Glu Leu Glu Phe Leu Arg Asn Asn Ile Cys Ile Lys Ser Asp Val Thr 
        835                 840                 845             


Met Glu Ser Phe Glu Ser Gln Ile Lys Gly Val Glu Ile Tyr Lys Asp 
    850                 855                 860                 


Leu Lys Glu Lys Ile Asp Lys Asn Asn Ser Leu Leu Asp Trp Tyr Val 
865                 870                 875                 880 


Ile Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asn 
                885                 890                 895     


Ile Lys Asn Tyr Ile Gln Phe Ala Thr Asn Ile Asp Lys Arg Ala Glu 
            900                 905                 910         


Ser Val Lys Asn Leu Thr Glu Ser Gly Met Val Lys Arg Ile Gln Tyr 
        915                 920                 925             


Tyr Asp Asp Ile Val Arg Thr Leu Glu Phe Ser Ala Gln Tyr Ile Gly 
    930                 935                 940                 


Lys Ile Ser Asn Asn Ile Asn Asp Tyr Phe Asn Ser Glu Asp Glu Tyr 
945                 950                 955                 960 


Val Ser Phe Leu Ser Lys Tyr Val Gly Phe Ile Asn Asp Lys Ser Glu 
                965                 970                 975     


Asp Val Leu Thr Glu Leu Lys Asp Phe Cys Arg Glu Lys Ile Asn Asn 
            980                 985                 990         


Gly Ser Gln Ile Ile Gly Ile Tyr  Tyr Gly Gly Asp Asn  Val Ile Ile 
        995                 1000                 1005             


Asn Arg  Asn Val Ile Tyr Ala  Gln Met Tyr Ser Asn  Ala Glu Val 
    1010                 1015                 1020             


Phe Ser  Asn Ile Tyr Lys Lys  Val Thr Lys Asn Asp  Ile Ile Asn 
    1025                 1030                 1035             


Tyr Tyr  Glu Lys Gln Asn Asp  Leu Lys Asp Val Phe  Lys Ser Gly 
    1040                 1045                 1050             


Val Cys  Gln Asn Glu Gly Glu  Gln Arg Ser Leu Cys  Glu Phe Gln 
    1055                 1060                 1065             


Gln Leu  Lys Asn Arg Ile Glu  Leu Thr Glu Leu Ser  Thr Tyr Ala 
    1070                 1075                 1080             


Asp Met  Val Asn Asp Phe Met  Ala Gln Phe Val Glu  Trp Ala Tyr 
    1085                 1090                 1095             


Leu Arg  Glu Arg Asp Leu Met  Tyr Phe Gln Leu Gly  Ile His Tyr 
    1100                 1105                 1110             


Ile Arg  Leu Phe Tyr Ser Asp  Asn Val Leu Asp Glu  Lys Tyr His 
    1115                 1120                 1125             


Lys Leu  Ser Asp Asn Val Ile  Asp Ile Glu Glu Gly  Ala Leu Leu 
    1130                 1135                 1140             


Tyr Gln  Ile Val Ala Met Tyr  Asp Tyr Glu Leu Arg  Ile Phe Glu 
    1145                 1150                 1155             


Thr Asp  Asn Ser Gly Asn Ala  Lys Arg Ile Gly Gln  Gly Gly Pro 
    1160                 1165                 1170             


Gly Lys  Ser Ile Pro Val Phe  Leu Lys Lys Tyr Cys  Asn Gly Thr 
    1175                 1180                 1185             


Asp Val  Tyr Glu Cys Gly Leu  Glu Leu Phe Glu Asp  Ile Asn Gln 
    1190                 1195                 1200             


His Glu  Asn Ile Ile Gly Phe  Arg Asn Asp Ile Ala  His Met Arg 
    1205                 1210                 1215             


Tyr Met  Ser Asn Gln Ala Met  Asn Ile Met Ser Ile  Val Ser Asn 
    1220                 1225                 1230             


Ile Tyr  Lys Ser Phe Phe Val  Tyr Asp Thr Lys Leu  Lys Lys Ser 
    1235                 1240                 1245             


Ile Ser  Leu Val Phe Lys Asn  Ile Leu Met Arg Tyr  Gly Val Ile 
    1250                 1255                 1260             


Ala Asp  Leu Val Phe Ser Tyr  Asn Asn Lys Asn Gln  Ser Ile Lys 
    1265                 1270                 1275             


Asp Asp  Met Asp Ile Asn Ile  Ile Asn Ile Lys Asn  Leu Lys Ser 
    1280                 1285                 1290             


Asp Lys  Tyr Val Tyr Lys Ile  Val Asn Glu Asp Ile  Val Lys Gln 
    1295                 1300                 1305             


Val Glu  Ile Glu Ile Arg Asn  Gln Val Phe Leu Glu  Gln Leu His 
    1310                 1315                 1320             


Asn Leu  Leu Tyr Phe Ser Arg  
    1325                 1330 


<210>  758
<211>  1391
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  758

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Lys Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn Gln Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Glu 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Ile Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Asn Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Val Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Phe Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Gln Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Met Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Cys Ile  Ser Ser Ile Lys Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Thr Leu Ile Thr Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Gly  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Gly Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Asn Lys Asn Lys Lys  Asn Lys Lys Asn Asn  Gly Asn Arg 
    1355                 1360                 1365             


Asp Glu  Lys Lys Asn Ser Asp  Gly Leu Thr Tyr Ser  Pro Phe Phe 
    1370                 1375                 1380             


Asp Leu  Pro Phe Glu Leu Pro  Glu 
    1385                 1390     


<210>  759
<211>  1104
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  759

Met Arg Ile Val Lys Pro His Gly Thr Ser Glu Thr His Phe Asp Lys 
1               5                   10                  15      


Glu Gly Arg Ile Arg Arg Tyr Val His Ser Asp Ser Phe Pro Cys Glu 
            20                  25                  30          


Pro Leu Glu Pro Lys Glu Phe Ala Thr Arg His Pro Lys Leu Val Ile 
        35                  40                  45              


Ala Gln Trp Val Ser Cys Ile Asp Lys Val Ile Thr Arg Pro His Gly 
    50                  55                  60                  


Asp Gly Leu Pro Ser Glu Thr Gln Trp Ser Leu Arg Asn Gly Leu Gly 
65                  70                  75                  80  


Lys Ala Ala Trp Asp Leu Ile Val Glu Arg Gly Leu Leu Asp Ala Pro 
                85                  90                  95      


Glu Lys Arg Leu Lys Arg Phe Glu Arg Gln Trp Trp Ala Arg Ile His 
            100                 105                 110         


Pro Tyr Gly Asn Glu Thr Asp Ala Asn Thr Pro Arg Asn Pro Tyr Gly 
        115                 120                 125             


His Trp Tyr Arg Ser Leu Ala Gly Gly Val Asp Ile Ala Glu Phe Asp 
    130                 135                 140                 


Pro Ala Thr Val Ala Asn Met Ile Tyr Ala His Leu Tyr Glu Asn Ala 
145                 150                 155                 160 


Ser Arg Thr His Pro Glu His Gly Pro Arg Arg Ser Gly Leu Ile Pro 
                165                 170                 175     


Glu Arg Ser Glu Ser Ile Ala Lys Ser Val Pro Ala Arg Thr Ala Pro 
            180                 185                 190         


Gly Gly Gly Arg Leu Ser Pro Pro Trp Asp Ala Ser Asp Gly Ala Ile 
        195                 200                 205             


Tyr Leu Glu Ala Gly Asp Val Ala Ala Thr Met Leu Glu Arg Leu Glu 
    210                 215                 220                 


Lys His Phe Gly Glu Arg His Ala Lys Leu Arg Arg Ile Cys Ala Ala 
225                 230                 235                 240 


Thr Leu Ala Glu His Leu Thr Arg Leu Arg Arg Glu Val Leu His Ile 
                245                 250                 255     


Ser Asp Gly Asp Arg Leu Pro Glu Ser Leu Tyr Gln Leu His Glu Gln 
            260                 265                 270         


Val Arg Arg Ser Tyr Ser Asp Ile Leu Lys Gly Asp Gln Arg Tyr Leu 
        275                 280                 285             


Ser Lys Lys Leu Pro Ser Ser Gly Asp Gln Leu Val Ser Leu Val Glu 
    290                 295                 300                 


Ser Lys Arg Leu Asn Arg Glu Val Ala Ala Leu Ile Arg Leu Gly Arg 
305                 310                 315                 320 


Val Ile His Tyr Glu Ser Thr Ala Glu Asn Gly Pro Ser His Thr Ser 
                325                 330                 335     


Asn Val Leu Asp His Trp Pro Ser Gln Thr Asp Ser Ser Arg Phe Trp 
            340                 345                 350         


Leu Ser Ala Gly Gln Thr Glu Ile Lys Arg Asn Glu Ala Phe Val Arg 
        355                 360                 365             


Ile Trp Arg Gly Ile Leu Ala Arg Ala Ala Arg Thr Ala Thr Asp Trp 
    370                 375                 380                 


Ala Asp Pro Glu Arg Ala Ile Pro Arg Asp Val Leu Gly Ala Lys Gln 
385                 390                 395                 400 


Leu Ser Glu Ala Val Thr Asn Ile Thr Asp Thr Ala Phe Asp Arg Lys 
                405                 410                 415     


Ala Lys Leu Leu Phe Gly Asn Arg Ser Asp Leu Leu Thr Ser Leu Pro 
            420                 425                 430         


Leu Glu Arg Lys Arg Gln Val Leu Asp Leu Ala Leu Arg Gly Leu Gly 
        435                 440                 445             


Gln Leu Arg Asn Asn Ala Phe His Phe Val Gly Leu Glu Ala Phe Leu 
    450                 455                 460                 


Ala Ser Leu Arg Gly Leu Asp Gly Ile Ala Asp Ala Asp Thr Arg Thr 
465                 470                 475                 480 


Val Leu Asp His Ile Trp Arg Asp Asp Thr Lys Asp Arg Asn Thr Arg 
                485                 490                 495     


Leu Val Gln Thr Ile Arg Ala Ser Asn Ala Pro Ala Tyr Phe Ser Arg 
            500                 505                 510         


Gln Glu Met Glu Gly Phe Val Ser Ser Ile Ala Arg Thr Pro Ala Val 
        515                 520                 525             


Phe Leu Glu Leu Pro Ala Phe Gly Arg Ile Leu Arg Arg Ala Ser Val 
    530                 535                 540                 


Ala Trp Thr Ile Asp Arg Tyr Arg Leu Thr Leu Pro Ala Pro Lys Ala 
545                 550                 555                 560 


Val Gly Glu Pro Val Ala Ala Glu Cys Gln Arg Val Cys Leu Gly Leu 
                565                 570                 575     


Ile Tyr Asp Arg Ala Phe Gly Asp Trp Leu Gln Val Leu Glu Thr Glu 
            580                 585                 590         


Arg Leu Arg Asp Cys Val Asp Arg Ala Val Thr Arg Ala Ser Val Glu 
        595                 600                 605             


Ala Arg Arg Val Thr Arg Asp Asp Thr Val Asn Ala Arg Thr Ile Gly 
    610                 615                 620                 


Lys Phe Lys Ile Thr Gln Gly Asp Thr Leu Glu Ser Phe Phe Ser Arg 
625                 630                 635                 640 


Leu Thr Ala Ala Val Thr Arg Glu Leu Arg Gln Thr Asp Ala Arg Lys 
                645                 650                 655     


Gln Thr Lys Arg Ala Ala Ser Lys His Leu Asp Asp Leu Arg Cys Asp 
            660                 665                 670         


Val Val Ala Gln Leu Phe Glu Ile Tyr Leu Lys Glu Ala Asp Leu Gly 
        675                 680                 685             


Trp Leu Leu Ser Gly Phe Gln Thr Arg Lys Pro Thr Gly Ala Ser Lys 
    690                 695                 700                 


Thr Asp Ala Ala Phe Cys Pro Pro Pro Ser Ser Ala Gln Thr Phe Gln 
705                 710                 715                 720 


Ala Trp Glu Pro Ile Leu Tyr Phe Ile Leu His Leu Val Pro Val Asp 
                725                 730                 735     


Thr Thr Thr Arg Leu Ala His Gln Val Gly Arg Phe Arg Asp Gly Gly 
            740                 745                 750         


Gln Ile Asp Thr Gly Leu Ile Glu Gly Leu Gln Arg Thr Leu Asp Leu 
        755                 760                 765             


Tyr Arg Val Met His Asp Ala Lys Phe Ala Gly Ala Ala Ser Gly Leu 
    770                 775                 780                 


Arg Pro Asp Glu Met Arg Ser Ile Leu Leu Lys Thr Gly Leu Tyr Ser 
785                 790                 795                 800 


Gly Ala Thr Glu Gly Thr Glu Leu Ala Phe Glu Thr Arg Gly Leu Arg 
                805                 810                 815     


Glu Phe Phe Arg Phe Gly Asp His His Leu Phe Thr Thr Asp Phe Ala 
            820                 825                 830         


Gln Asn Pro Val Thr Arg Asp Gln Phe His Glu Ile Lys Ser Leu Arg 
        835                 840                 845             


Ala Asp Leu Ala Leu Ala Gln Asp Arg Arg Ser Ala Leu His Ala Glu 
    850                 855                 860                 


Trp Val Ser Asn Gly Lys Ala Leu Ser Gly Ala Lys His Asp Glu Tyr 
865                 870                 875                 880 


Arg Ala Leu Leu Asn Arg Ile Glu Arg Gly Arg His Leu Ser Asp His 
                885                 890                 895     


Ala Glu Leu Arg Asp His Leu Arg Leu His Gly Ile Leu Ile Asp Val 
            900                 905                 910         


Leu Ala Arg Leu Leu Asp Phe Ala Gly Gln Trp Glu Arg Asp Leu Tyr 
        915                 920                 925             


Phe Thr Thr Leu Ala Leu Ile His Leu Ala Gly Thr Thr Pro Gln Asp 
    930                 935                 940                 


Ala Phe Asp Asp Arg Arg Gly Trp His Ala Val Arg Thr Gly Gln Ile 
945                 950                 955                 960 


Leu Ala Ala Leu Arg Ser Thr Arg Asp Thr Pro Glu Met Gln Asp Ile 
                965                 970                 975     


Leu Ala Lys Leu Ala Met Val Phe Asn Ile Asp Met Pro Gly Val Arg 
            980                 985                 990         


Gly Ala Asn Val Arg Thr Arg Asn  Asp Leu Ala His Phe  Asn Cys Leu 
        995                 1000                 1005             


His Thr  Pro Ala Ala Ser Ile  Asp Leu Thr Ala Leu  Ile Asn Arg 
    1010                 1015                 1020             


Thr Arg  Ala Leu Met His Tyr  Asp Arg Lys Gln Glu  Asn Ala Val 
    1025                 1030                 1035             


Ser Lys  Ser Val Ile Glu Leu  Leu Asp Arg His Lys  Leu Val Leu 
    1040                 1045                 1050             


Ser Trp  Thr Phe Ser Gly Gly  Gln Leu Gly Lys Ser  Thr Val Arg 
    1055                 1060                 1065             


Pro Lys  Val Ile Arg His Leu  Glu Gln Pro Glu Val  Lys Glu Cys 
    1070                 1075                 1080             


Leu Val  Ser Thr Ala Phe Ser  Ala Ala Val Gly Arg  Leu Phe Gly 
    1085                 1090                 1095             


Ala Thr  Glu Lys Asp Gly 
    1100                 


<210>  760
<211>  1299
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  760

Val Lys Val Thr Lys Val Asn Ser Ala Arg Val Ala Val Val Ser Lys 
1               5                   10                  15      


Lys Leu Lys Asn Ser Arg Ala Val Leu Tyr Ala Thr Thr Ala Asn Lys 
            20                  25                  30          


Gly Val Ser Glu Asp Ser Glu Ser Phe Ile Val Lys Arg Ile Asp Ala 
        35                  40                  45              


Ala Asn Arg Leu Tyr Gly Val Phe Phe Arg Gly Asn Asn Lys Thr Val 
    50                  55                  60                  


Pro Leu Pro Asn Gly Ile Glu Asn Lys Phe Thr Gln Leu Leu Asn Tyr 
65                  70                  75                  80  


Met Glu Tyr Glu His Arg Gly Lys Ile Leu Ala Ala Tyr Arg Thr Gly 
                85                  90                  95      


Asp Ala Ser Gln Ile Asn Gln Cys Val Asp Asp Gln Ile Ala Trp Leu 
            100                 105                 110         


Lys Lys Ile Gln Ile Ile Lys Arg Val Lys Trp Lys Ser Lys Ala Glu 
        115                 120                 125             


Lys Tyr Tyr Val Asp Asp Lys Asp Ser Ile Lys Arg Ile Asp Phe Lys 
    130                 135                 140                 


Thr Gln Lys Asp Ile Ser Glu Asp Val Leu Asp Asp Ala Ile Lys Arg 
145                 150                 155                 160 


Met Arg Lys Ser Leu Lys Arg Gly Ser Asn Arg Trp Ile Val Lys Arg 
                165                 170                 175     


Leu Ile Arg Ala Leu Ala Gln Gly Asp Glu Thr Val Tyr Ile Thr Val 
            180                 185                 190         


Leu Glu Asp Ala Ala Phe Pro Lys Phe Val Asp Ala Val Asn Lys Asp 
        195                 200                 205             


Tyr Tyr Lys Thr Asn Leu Leu Arg Ser Leu Ala Arg His Asp Val Lys 
    210                 215                 220                 


Val Gln Val His Ser Asp Tyr Ile Leu Asp Leu Ala Ser Val Asp Asn 
225                 230                 235                 240 


Ala Lys Ala Asn Lys Lys Ala Leu Thr Gln Ile Leu Glu Lys Tyr Ala 
                245                 250                 255     


Ser Ser Glu Lys Ala Ala Thr Glu Thr Leu Leu Glu Met Lys Arg Ile 
            260                 265                 270         


Phe Phe Ala Tyr Phe Phe Ser Phe Asp Asp Glu Lys Tyr Gly Lys Phe 
        275                 280                 285             


Phe Ala Ser Glu Asn Leu Trp Lys Val Pro Ser Glu Thr Ile Gln Glu 
    290                 295                 300                 


Asp Val Gly Gly Tyr Phe Asp Glu Gly Phe Ile Pro Leu Asp Gly Tyr 
305                 310                 315                 320 


Ala Asp Lys Phe Asp Tyr Thr Ile Glu Asp Leu Thr Arg Glu Lys Pro 
                325                 330                 335     


Leu Asn Ile Gly Lys Leu Lys Ala Arg Val Arg Phe Val Asn Phe Gly 
            340                 345                 350         


Lys Tyr Leu Gln Met Met Ser Gln Asp Asn Tyr Asn Gly Asp Glu Ile 
        355                 360                 365             


Ala Gln Tyr Trp Ile Asn Tyr Ala Lys Glu Tyr Val Glu Glu Asn Tyr 
    370                 375                 380                 


Gln Ala Lys Asp Tyr Lys Asn Arg Lys Val Asp Ile Asp Ser Tyr Lys 
385                 390                 395                 400 


Arg Ile Arg Met Phe Lys Ala Cys Trp Lys Asp Ala Val Arg Phe Ile 
                405                 410                 415     


Cys Gly Lys Tyr Ile Asp Leu Gly Lys Ala Val Tyr His Phe Ala Met 
            420                 425                 430         


Pro Lys Lys Leu Ser Glu Lys Leu Glu Ser Gly Asn Glu Tyr Gly Arg 
        435                 440                 445             


Ile Arg Glu Glu Tyr Arg Asn Gly Ile Ser Ser Phe Ala Tyr Glu Ala 
    450                 455                 460                 


Ile Lys Ala Glu Glu Thr Leu Gln Arg Asn Ile Ala Asn Ala Thr Val 
465                 470                 475                 480 


Ala Ala Leu Ser Ala Phe Ser Arg Ser Val Leu Asp Tyr Ser Lys Gln 
                485                 490                 495     


Ser Glu Ala Gly Lys Glu Asp Ile Leu Phe Met Ser Lys Asp Gln Leu 
            500                 505                 510         


Lys Asn Leu Arg Lys Glu Asp Val Leu Lys Pro Ile Leu Arg Tyr Tyr 
        515                 520                 525             


Gly Gly Gln Ser Glu Val Lys Ala Phe Asp Leu Asn Gly Ile Ala Leu 
    530                 535                 540                 


Met Glu Glu Ile Met Gly His Phe Ser Leu Ile Arg Asn Glu Asn Phe 
545                 550                 555                 560 


His Tyr Ala Pro Gly Lys Leu Gly Glu Ile Lys Tyr Glu Asn Ser Leu 
                565                 570                 575     


Lys Leu Trp Gln Asn Asp Val Asp Val Tyr Ala Gln Val Val Arg Gln 
            580                 585                 590         


Lys Tyr Tyr Ser Asn Asn Thr Ala Val Phe Tyr Gly Lys Glu Asn Ile 
        595                 600                 605             


Thr Lys Leu Phe Thr Ala Leu His Gly Lys Lys Arg Val Ser Ala Ser 
    610                 615                 620                 


Gln Ile Pro Ala Phe Arg Ser Ile Trp Arg Arg Gln Glu Ile Ser Ala 
625                 630                 635                 640 


Phe Val Lys Val Ile Glu Lys Lys Ala Ala Lys Ala Lys His Glu Cys 
                645                 650                 655     


Ser Phe Leu Asn Asn Glu Glu Glu Arg Ile Lys Tyr Glu Gly Ala Leu 
            660                 665                 670         


Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Asn Asp Phe Ile Phe Leu Asp 
        675                 680                 685             


Tyr Lys Ala Arg Asp Tyr Phe Val Lys Ala Val Asn Asp Tyr Thr Gly 
    690                 695                 700                 


Thr Asp Gly Ile Ala Gln Ser Thr Gln Ala Ala Asn Asn Phe Lys Glu 
705                 710                 715                 720 


Tyr Val Gly Asn Leu Ala Gly Leu Asn Leu Thr Phe Ala Gln Ile Cys 
                725                 730                 735     


Gln Lys Ile Gln Gln Glu Tyr Asn Gln Gln Asn Thr Asn Ala Lys Lys 
            740                 745                 750         


Ser Gly Lys Thr Glu Glu Ser Tyr Ala His Phe Lys Met Leu Leu Pro 
        755                 760                 765             


Met Cys Val Lys Ser Ala Phe Gln Gln Tyr Leu Ala Asp Asn Tyr Lys 
    770                 775                 780                 


Phe Leu Phe Lys Pro Glu Phe Asn Glu Ala Leu Glu Asp Glu Gln Asp 
785                 790                 795                 800 


Tyr Leu Asp Glu Val Leu Val Asp Cys Gly Val Ala Ile Lys Gly Ile 
                805                 810                 815     


Pro Asp Asn Asp Lys Glu Lys Arg Arg Leu Ala Trp Phe Thr Phe Ala 
            820                 825                 830         


His Phe Val His Pro Lys Gln Leu Asn Leu Leu Ile Gly Asp Phe Lys 
        835                 840                 845             


Ser Tyr Ile Gln Tyr Arg Asn Asp Val Phe Lys Arg Ala Gly Phe Ala 
    850                 855                 860                 


Asp Glu Tyr Gly Ser Ala Glu Glu Lys Asp Arg Ala Glu Lys Glu Lys 
865                 870                 875                 880 


Asp Val Ser Ile Lys Arg Ala Lys Ser Ile Leu Asp Val Leu Glu Phe 
                885                 890                 895     


Val Arg Pro Ile Ala Gly Arg Val Ser Asn Val Phe Asp Asp Tyr Tyr 
            900                 905                 910         


Asp Asn Glu Asp Glu Tyr Ala Arg Tyr Leu Ser Asn Tyr Ile Thr Phe 
        915                 920                 925             


Ser Ser Lys Asn Glu Glu Pro Thr Phe Lys Asn Leu Lys Leu Phe Cys 
    930                 935                 940                 


Glu Asn Thr Leu Ala Asp Gly Ala Met Val Asp Ile Tyr Ala Asp Lys 
945                 950                 955                 960 


Ala Asn Pro Lys Val Leu Arg Asn Val Glu Ile Ala Arg Met Tyr Ala 
                965                 970                 975     


Gly Gly Asp Val Ile Leu Asn Gly Ile Glu Lys Val Asp Ala Lys Lys 
            980                 985                 990         


Val Arg Lys Tyr Tyr Glu Asn Lys  Ala Ala Ala Leu Glu  Leu Gln Lys 
        995                 1000                 1005             


Lys Gly  Leu Cys Ala Asn Glu  Glu Glu Gln Arg Lys  Ile Ile Lys 
    1010                 1015                 1020             


Gln Gln  Gln Leu Lys Gly Gln  Leu Met Leu Asn Asp  Val Thr Glu 
    1025                 1030                 1035             


Thr Phe  Ser Leu Val Asn Asp  Met Leu Gly Gly Leu  Val Ser Leu 
    1040                 1045                 1050             


Ser Tyr  Leu Arg Glu Arg Asp  Lys Met Tyr Leu Leu  Leu Gly Tyr 
    1055                 1060                 1065             


Tyr Tyr  Met Ala Leu Arg Asn  Val Ser Asn Trp Ser  Asn Glu Lys 
    1070                 1075                 1080             


Leu Asp  Ser Val Val Glu Asp  Asp Ile Asn Ile Lys  Ser Gly Phe 
    1085                 1090                 1095             


Val Leu  Tyr Gln Val Val Ser  Met Phe Asp Tyr Gly  Thr Ser Phe 
    1100                 1105                 1110             


Leu Tyr  Phe Asp Ser Glu Lys  Asn Lys Trp Leu Glu  Met Val Asn 
    1115                 1120                 1125             


Ala Ser  Ile Asn Leu Lys Gly  Arg Lys Phe Gly Glu  Met His Ala 
    1130                 1135                 1140             


Ala Ser  Arg Ala Cys Ala Ile  Gln Leu Phe Glu Met  Asp Glu Gln 
    1145                 1150                 1155             


Ala Lys  Asp Lys Lys Gln Lys  Lys Pro Asp Thr Gln  Asp Lys Lys 
    1160                 1165                 1170             


Asp Lys  Glu Met Ser Val Arg  Glu Leu Arg Asn Tyr  Val Asp His 
    1175                 1180                 1185             


Phe Lys  Tyr Tyr Val Lys Phe  Asp Lys Ser Ile Val  Glu Leu Tyr 
    1190                 1195                 1200             


Ala Glu  Phe Tyr Thr Lys Phe  Phe Val Tyr Ser Thr  Lys Leu Arg 
    1205                 1210                 1215             


Lys Ser  Val Ile Val Asn Phe  Ser Asn Ile Leu Glu  Arg Tyr Phe 
    1220                 1225                 1230             


Leu Glu  Asn Ser Asn Ser Phe  Thr Val Leu Glu Asp  Asn Lys Thr 
    1235                 1240                 1245             


Glu Ile  Asn Leu Leu Ser Thr  Leu Lys Ser Gln Gln  Phe Thr Tyr 
    1250                 1255                 1260             


Lys Leu  Asn Ala Lys Asp Asn  Lys Gly Lys Gln Leu  Thr Cys Asn 
    1265                 1270                 1275             


Leu Asn  Ala Lys Ser Ala Asn  Phe Val Lys Ser Val  Lys Glu Val 
    1280                 1285                 1290             


Leu Lys  Tyr Lys Lys Cys 
    1295                 


<210>  761
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  761

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Asp Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Cys Gln Arg Ile Ile Asn Asp Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His 
            180                 185                 190         


Glu Arg Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Arg Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Ile His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Ile  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Arg Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  762
<211>  1204
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  762

Met Lys Val Thr Lys Ile Asp Gly Ile Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Arg Tyr Thr Gly Asn Phe Asn Ile Lys Asn Glu 
            20                  25                  30          


Met Lys Glu Arg Leu Glu Lys Leu Lys Glu Leu Lys Leu Ser Asn Tyr 
        35                  40                  45              


Ile Lys Asn Pro Glu Asn Val Lys Asn Lys Asp Lys Asn Lys Glu Lys 
    50                  55                  60                  


Glu Thr Lys Ser Arg Arg Glu Asn Leu Lys Lys Tyr Phe Ser Glu Ile 
65                  70                  75                  80  


Ile Leu Arg Lys Lys Glu Glu Lys Tyr Leu Leu Lys Lys Thr Arg Lys 
                85                  90                  95      


Phe Lys Asn Ile Thr Glu Glu Ile Asn Tyr Asp Asp Ile Lys Lys Arg 
            100                 105                 110         


Glu Asn Gln Gln Lys Ile Phe Asp Val Leu Lys Glu Leu Leu Glu Gln 
        115                 120                 125             


Arg Ile Asn Glu Asn Asp Lys Glu Glu Ile Leu Asn Phe Asp Ser Val 
    130                 135                 140                 


Lys Leu Lys Glu Ala Phe Gly Glu Asp Phe Ile Lys Lys Glu Ser Lys 
145                 150                 155                 160 


Ile Lys Ala Ile Glu Glu Ser Leu Glu Lys Asn Arg Ala Asp Tyr Arg 
                165                 170                 175     


Lys Gly Phe Val Glu Leu Glu Asn Gly Lys Tyr Glu Asp Val Lys Gly 
            180                 185                 190         


Gln Asn Lys Arg Ser Leu Val Phe Glu Tyr Tyr Lys Asn Pro Glu Asn 
        195                 200                 205             


Arg Glu Lys Phe Lys Glu Asn Ile Lys Tyr Ala Phe Glu Asn Leu Tyr 
    210                 215                 220                 


Ile Glu Glu Asn Ile Lys Asn Leu Tyr Ser Glu Ile Glu Glu Ile Phe 
225                 230                 235                 240 


Glu Lys Val His Leu Lys Ser Lys Val Arg Asp Phe Tyr Gln Asn Gly 
                245                 250                 255     


Ile Ile Gly Glu Ser Glu Phe Ser Glu Lys Asp Glu Glu Gly Ile Ser 
            260                 265                 270         


Ile Leu Tyr Lys Gln Ile Ile Asn Ser Val Glu Lys Lys Glu Lys Phe 
        275                 280                 285             


Val Glu Phe Leu Gln Lys Val Lys Ile Lys Asp Leu Thr Arg Ser Gln 
    290                 295                 300                 


Ile Phe Tyr Lys Tyr Phe Leu Glu Asn Glu Glu Leu Asn Asp Glu Asn 
305                 310                 315                 320 


Ile Lys Tyr Val Phe Ser Tyr Phe Val Glu Ile Glu Val Asn Lys Leu 
                325                 330                 335     


Leu Lys Glu Asn Val Tyr Lys Thr Lys Lys Phe Asn Glu Gly Asn Lys 
            340                 345                 350         


Tyr Arg Val Lys Asn Ile Phe Asn Tyr Asp Lys Leu Lys Asn Leu Val 
        355                 360                 365             


Val Tyr Lys Leu Glu Asn Lys Leu Asn Asn Tyr Ile Arg Asn Cys Gly 
    370                 375                 380                 


Lys Tyr Asn Tyr His Met Glu Asn Gly Cys Val Ala Thr Ser Asp Thr 
385                 390                 395                 400 


Asn Met Lys Asn Arg Gln Thr Glu Ala Phe Leu Arg Ser Ile Leu Gly 
                405                 410                 415     


Val Ser Ser Phe Gly Tyr Phe Ser Leu Arg Asn Ile Leu Gly Val Asn 
            420                 425                 430         


Asp Asn Asp Phe Tyr Glu Met Glu Glu Glu Leu Thr Glu Asp Glu Arg 
        435                 440                 445             


Lys Asn Glu Asn Phe Ile Leu Lys Lys Ala Lys Glu Asp Ile Thr Ser 
    450                 455                 460                 


Lys Asn Ile Phe Glu Lys Val Val Asp Lys Ser Phe Glu Lys Lys Gly 
465                 470                 475                 480 


Ile Tyr Gln Ile Lys Glu Asn Leu Lys Met Phe Tyr Gly Asn Ser Phe 
                485                 490                 495     


Asp Lys Val Asp Lys Asp Glu Leu Lys Lys Phe Phe Val Asn Met Leu 
            500                 505                 510         


Glu Ala Ile Thr Ser Val Arg His Arg Ile Val His Tyr Asn Ile Asn 
        515                 520                 525             


Thr Asn Ser Glu Asn Ile Phe Asp Phe Ser Asn Ile Glu Val Ser Lys 
    530                 535                 540                 


Leu Leu Lys Asn Ile Phe Glu Lys Glu Ile Asp Thr Arg Glu Leu Lys 
545                 550                 555                 560 


Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Gly Val Phe Asp Tyr Trp 
                565                 570                 575     


Glu Ser Trp Val Ile Lys Lys Tyr Leu Glu Asn Val Lys Phe Glu Phe 
            580                 585                 590         


Val Asn Lys Asn Val Pro Phe Val Pro Ser Phe Lys Lys Leu Tyr Asp 
        595                 600                 605             


Arg Ile Asp Asn Leu Lys Gly Trp Asn Ala Leu Lys Leu Gly Asn Asn 
    610                 615                 620                 


Ile Asn Ile Pro Lys Arg Lys Glu Ala Lys Asp Ser Gln Ile Tyr Leu 
625                 630                 635                 640 


Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Val Glu Lys Phe Val Asn Asp 
                645                 650                 655     


Asn Lys Asn Phe Glu Lys Ile Val Lys Glu Ile Ile Glu Ile Asn Arg 
            660                 665                 670         


Gly Ala Gly Thr Asn Lys Lys Thr Gly Phe Tyr Lys Leu Glu Lys Phe 
        675                 680                 685             


Glu Thr Leu Lys Ala Asn Thr Pro Ile Glu Tyr Leu Glu Glu Leu Gln 
    690                 695                 700                 


Ser Leu His Lys Ile Ser Tyr Asp Lys Glu Lys Ile Glu Glu Asp Lys 
705                 710                 715                 720 


Asp Ile Tyr Val Asp Phe Val Gln Lys Ile Phe Leu Lys Gly Phe Val 
                725                 730                 735     


Asn Tyr Leu Lys Lys Leu Asp Ser Leu Lys Ser Leu Asn Leu Leu Asn 
            740                 745                 750         


Leu Arg Lys Asp Glu Thr Ile Thr Asp Lys Lys Ser Val His Asp Glu 
        755                 760                 765             


Lys Leu Lys Leu Trp Glu Asn Ser Gly Ser Asn Leu Ser Lys Met Pro 
    770                 775                 780                 


Glu Glu Ile Tyr Glu Tyr Val Lys Lys Ile Lys Ile Ser Asn Ile Asn 
785                 790                 795                 800 


Tyr Asn Asp Arg Met Ser Ile Phe Tyr Leu Leu Leu Lys Leu Ile Asp 
                805                 810                 815     


Tyr Arg Glu Leu Thr Asn Leu Arg Gly Asn Leu Glu Lys Tyr Glu Ser 
            820                 825                 830         


Met Asn Lys Asn Glu Ile Tyr Ser Glu Glu Leu Thr Ile Ile Asn Leu 
        835                 840                 845             


Val Asn Leu Asp Asn Asn Lys Val Arg Thr Asn Phe Ser Leu Glu Ala 
    850                 855                 860                 


Glu Asp Ile Gly Lys Phe Leu Lys Ser Ser Ile Pro Ile Lys Asn Val 
865                 870                 875                 880 


Ala Gln Leu Asn Asn Phe Ser Lys Ile Phe Ala Asp Gly Glu Asn Val 
                885                 890                 895     


Ile Lys His Arg Ser Phe Tyr Asn Ile Lys Lys Tyr Gly Ile Leu Asp 
            900                 905                 910         


Leu Leu Glu Lys Ile Val Ala Lys Ala Asp Leu Lys Ile Ala Lys Glu 
        915                 920                 925             


Glu Ile Lys Lys Tyr Glu Asn Leu Gln Lys Glu Leu Glu Lys Asn Asp 
    930                 935                 940                 


Phe Tyr Lys Ile Gln Glu Lys Ile His Arg Lys Tyr Asn Gln Lys Pro 
945                 950                 955                 960 


Asn Leu Ile Leu Arg Thr Glu Asn Lys Lys Asp Phe Asn Asp Tyr Lys 
                965                 970                 975     


Lys Ala Ile Glu Asn Ile Gln Asn Tyr Thr Gln Leu Lys Asn Lys Ile 
            980                 985                 990         


Glu Phe Asn Asp Leu Asn Leu Leu  Gln Ser Leu Leu Phe  Arg Ile Leu 
        995                 1000                 1005             


His Arg  Leu Ala Gly Tyr Thr  Ser Leu Trp Glu Arg  Asp Leu Gln 
    1010                 1015                 1020             


Phe Lys  Leu Lys Gly Glu Phe  Pro Glu Asp Lys Tyr  Ile Asp Glu 
    1025                 1030                 1035             


Ile Phe  Asn Phe Asp Asn Ser  Lys Asn Lys Ile Tyr  Asn Glu Lys 
    1040                 1045                 1050             


Asn Lys  Arg Gly Gly Ser Ile  Val Ser Lys Tyr Gly  Tyr Phe Leu 
    1055                 1060                 1065             


Ala Glu  Lys Asp Gly Glu Ile  Gln Glu Ser Arg Ala  Arg Asp Lys 
    1070                 1075                 1080             


Lys Lys  Lys Lys Ile Ile Lys  Lys Glu Gly Leu Glu  Ile Arg Asn 
    1085                 1090                 1095             


Tyr Ile  Ala His Phe Asn Tyr  Ile Pro Asp Ala Glu  Lys Ser Ile 
    1100                 1105                 1110             


Leu Glu  Met Leu Glu Glu Leu  Arg Glu Leu Leu Lys  Tyr Asp Arg 
    1115                 1120                 1125             


Lys Leu  Lys Asn Ala Val Met  Lys Ser Ile Lys Asp  Ile Phe Lys 
    1130                 1135                 1140             


Glu Tyr  Gly Phe Ile Val Glu  Phe Thr Ile Ser His  Thr Lys Asn 
    1145                 1150                 1155             


Gly Lys  Lys Ile Lys Val Cys  Ser Val Lys Ser Glu  Lys Ile Lys 
    1160                 1165                 1170             


His Leu  Lys Asn Asn Glu Leu  Ile Thr Thr Arg Asn  Ser Glu Asp 
    1175                 1180                 1185             


Leu Cys  Glu Leu Val Lys Ile  Met Leu Glu Tyr Lys  Glu Leu Gln 
    1190                 1195                 1200             


Lys 
    


<210>  763
<211>  927
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  763

Leu Gly Lys Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp 
1               5                   10                  15      


Lys Lys Val Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly 
            20                  25                  30          


Ile Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln 
        35                  40                  45              


Arg Glu Leu Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg 
    50                  55                  60                  


Ala Val Cys Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu 
65                  70                  75                  80  


Ile Trp Asn Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp 
                85                  90                  95      


Met Ala Ser Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser 
            100                 105                 110         


Trp Asp Ile Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn 
        115                 120                 125             


Tyr Glu Val Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala 
    130                 135                 140                 


Arg Asn Glu Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile 
145                 150                 155                 160 


Trp Asn Thr Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile 
                165                 170                 175     


Cys Leu Asp Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val 
            180                 185                 190         


Phe Tyr Ser Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn 
        195                 200                 205             


Asn Lys Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met 
    210                 215                 220                 


Val Arg Lys Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln 
225                 230                 235                 240 


Lys Pro Gly Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys 
                245                 250                 255     


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
            260                 265                 270         


Glu Ala Leu Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp 
        275                 280                 285             


Asn Lys Asp Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys 
    290                 295                 300                 


Asn Ile Lys Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr 
305                 310                 315                 320 


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser 
                325                 330                 335     


Ser Lys Asp Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu 
            340                 345                 350         


Leu Leu Lys Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His 
        355                 360                 365             


Asn Glu Glu Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys 
    370                 375                 380                 


Leu Lys Glu Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys 
385                 390                 395                 400 


Lys Tyr Val Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln 
                405                 410                 415     


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu 
            420                 425                 430         


Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys 
        435                 440                 445             


Arg Arg Ala Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn 
    450                 455                 460                 


Leu Asp Val Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu 
465                 470                 475                 480 


Leu Ser Ser Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys 
                485                 490                 495     


Asp Asp Tyr Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser 
            500                 505                 510         


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly 
        515                 520                 525             


Lys Val Asp Leu Tyr Val Asp Pro Ser Asn Pro Lys Val Asn Arg Asn 
    530                 535                 540                 


Ile Val Gln Ser Lys Leu Phe Ala Ala Asp Tyr Ile Leu Arg Asp Ile 
545                 550                 555                 560 


Ile Glu Pro Val Ser Lys Asp Glu Ile Glu Asp Phe Tyr Asn Gln Lys 
                565                 570                 575     


Asp Glu Ile Thr Thr Cys Lys Ile Lys Gly Ala Glu Leu Thr Asp Glu 
            580                 585                 590         


Glu Gln Lys Lys Ile Leu Lys Tyr Gln Lys Leu Lys Asn Arg Val Glu 
        595                 600                 605             


Leu Arg Asp Val Val Glu Tyr Gly Glu Ile Ile Asn Glu Leu Leu Gly 
    610                 615                 620                 


Gln Leu Ile Asn Trp Ser Phe Met Arg Glu Arg Asp Leu Leu Tyr Phe 
625                 630                 635                 640 


Gln Leu Gly Phe His Tyr Asn Cys Leu Arg Asn Asp Ser Ala Lys Pro 
                645                 650                 655     


Glu Glu Tyr Lys Asn Leu Val Leu Asp Asp Ile Ser Ile Lys Asp Ala 
            660                 665                 670         


Ile Leu His Gln Ile Ile Gly Val Tyr Val Asn Gly Ala Ala Ile Tyr 
        675                 680                 685             


Ala Pro Gly Lys Asp Lys Asn Lys Leu Glu Ser Gln Cys Val Lys Gly 
    690                 695                 700                 


Arg Val Gly Gly Lys Ile Gly Ala Phe Cys Gly Tyr Ser Leu Tyr Leu 
705                 710                 715                 720 


Lys Leu Ala Ala Asp Thr Leu Tyr Asn Ala Gly Leu Glu Val Phe Glu 
                725                 730                 735     


Val Leu Pro Glu His Glu Asp Ile Ile Asn Leu Arg Asn Gly Ile Asp 
            740                 745                 750         


His Phe Lys Phe Tyr Leu Gly Gly Tyr Arg Ser Ile Ile Ser Leu Tyr 
        755                 760                 765             


Ser Glu Val Phe Asp Arg Phe Phe Thr Tyr Asp Met Lys Tyr Gln Lys 
    770                 775                 780                 


Asn Val Leu Asn Leu Leu Gln Asn Ile Leu Leu Arg His Asn Val Ile 
785                 790                 795                 800 


Ile Glu Pro Ile Phe Glu Ser Gly Ile Lys Lys Ile Gly Lys Asp Thr 
                805                 810                 815     


Lys Pro Cys Ala Lys Leu Ser Ile Arg Ser Ile Ile Ser Asp Ser Phe 
            820                 825                 830         


Glu Tyr Lys Ile Lys Asp Gly Asn Leu Ile Ala Asp Ala Lys Asp Lys 
        835                 840                 845             


Arg Tyr Leu Glu Thr Ile Lys Lys Ile Leu Phe Tyr Pro Glu Val Glu 
    850                 855                 860                 


Pro Glu Val Arg Ile Leu Ser Ser Lys Asp Ser Phe Glu Gln Asn Asn 
865                 870                 875                 880 


Gln Tyr Gly Tyr Met Lys Glu Lys Ser Glu Asn Asn Lys Asn Lys Lys 
                885                 890                 895     


Asn Lys Lys Asn Asn Gly Asn Arg Asp Glu Lys Lys Asn Ser Asp Gly 
            900                 905                 910         


Leu Thr Tyr Asn Pro Phe Leu Asn Leu Pro Phe Glu Leu Pro Glu 
        915                 920                 925         


<210>  764
<211>  1208
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  764

Met Gln Ile Ile Lys Pro Tyr Gly Arg Ser Phe Thr Glu Thr Asn Gln 
1               5                   10                  15      


Arg Val Leu Leu Asp Lys His Arg Asp Lys His Asp Ile Ser Pro Phe 
            20                  25                  30          


Ala Ala Ser His Glu Lys Leu Val Ile Ala Gln Trp Val Ser Val Ile 
        35                  40                  45              


Asp Lys Ile Val Arg Lys Pro Asn Pro Lys Ala Lys Ile Ser Leu Pro 
    50                  55                  60                  


Thr Pro Gln Gln Tyr Gln Leu Arg Glu Thr Leu Gly Asn Ala Ala Trp 
65                  70                  75                  80  


Leu Glu Leu Asn Lys Arg Leu Pro Cys Ser Asp His Ala Val Phe Trp 
                85                  90                  95      


Arg Ser Lys Ile His Pro Tyr Gly His Ala Thr Gln Glu Gln Glu Pro 
            100                 105                 110         


Ala Pro Leu Leu Gln Gly Arg Trp Tyr Gln Arg Phe Val Gly Asp Ile 
        115                 120                 125             


Glu Pro Thr Ala Ile Thr Glu Asn Val Ala Gln Ile Ile Ala Glu Arg 
    130                 135                 140                 


Ile Ala Ser His Leu Tyr Glu Ala Glu Leu Arg Leu Ser Pro Glu Ala 
145                 150                 155                 160 


Glu Pro Arg Gly Lys Gly Lys Ile Gln Ala Gln Ala Glu Ser Ile Glu 
                165                 170                 175     


Lys Asn Thr Leu His Gln Pro Lys Leu Ser Ala Thr Trp Cys Asp Ala 
            180                 185                 190         


Asp Trp Thr Ala Tyr Asn Arg His Asp Val Ala Glu Arg Ile Tyr Leu 
        195                 200                 205             


Glu Ala Lys Phe Arg Leu Glu Gln Lys Gln Glu Ala Arg Lys Asn Lys 
    210                 215                 220                 


Gln Pro Met Gln Leu Glu Trp Arg Ile Asp Arg Ser Leu Thr Gly Lys 
225                 230                 235                 240 


Ile Leu Phe Glu His Trp Ala Lys Val Tyr Ser Gly Thr Asp Gly Lys 
                245                 250                 255     


Ser Arg Ile Thr Glu Ala Lys Gln Glu Lys Pro Gly Leu Phe His Leu 
            260                 265                 270         


His Met Ala Val Lys Asp Phe Tyr Thr Arg Leu Phe Asp Arg Asp Arg 
        275                 280                 285             


Arg Asp Glu Thr Leu Val Glu Phe Leu Leu Pro Arg Lys Lys Lys Ala 
    290                 295                 300                 


Leu Arg Glu Lys Leu Glu Gln Lys Ser Lys Asn Thr Asp Leu Ala Ala 
305                 310                 315                 320 


Ser Ile Arg Leu Gly Lys Ile Leu Tyr Tyr Arg Glu Ala Glu Ser Glu 
                325                 330                 335     


Thr Val Pro Leu Ala Asn Ser Arg Phe Trp Gly Ser Glu Gly Gln Ala 
            340                 345                 350         


Glu Ile Lys Arg Ala Glu Ala Phe Val Arg Val Trp Arg His Val Leu 
        355                 360                 365             


Gly Gln Ser Asn Leu Thr Leu Ala Asn Trp Ala Ser Leu Ala Ser Pro 
    370                 375                 380                 


Asp Glu Leu Trp Glu Lys Asp Ser Phe Asp Ser Lys Phe Leu Asp His 
385                 390                 395                 400 


Val Glu Lys Leu Phe Ala Lys Asp Asn Gly Leu Asp Lys Arg Arg Gln 
                405                 410                 415     


Glu Phe Asp Gln Asn Leu Asn Leu Leu Leu Gly Asp Gly Ala Ser Ala 
            420                 425                 430         


Phe Met Ala Asp Asp Asp Ser Arg Gln Ala Ala Ile Arg Leu Ala Tyr 
        435                 440                 445             


Asp Val Gly Ser Ala Leu Arg His Ala Ala Phe His Phe Lys Gly Arg 
    450                 455                 460                 


Asp Lys Phe Leu Glu Val Leu Asp Lys Asp Leu Ser Asp Lys Gly Gln 
465                 470                 475                 480 


Ala Ser Gly Leu Leu Leu Pro Leu Asn Lys Leu Leu Ala Thr Ala Gln 
                485                 490                 495     


Glu Lys Gln Asp Glu Arg Leu Leu Ala Thr Leu Glu Gly Ala His Val 
            500                 505                 510         


Phe Gln Val Cys Thr Gln Ala Gln Val Gln Gln Leu Val Asn Ser Ile 
        515                 520                 525             


Cys Ala Ile Pro Thr Gly Asp Leu Pro Leu Pro Arg Phe Gly Arg Val 
    530                 535                 540                 


Ile Glu Arg Asn His Asn Ala Gly Leu Lys Thr Gly Leu Pro Ser Arg 
545                 550                 555                 560 


Val Asn Arg Gln Ala Met Glu Gln Asn Pro Ala Gln Lys Cys Gln Tyr 
                565                 570                 575     


Val Val Leu Lys Met Leu Tyr Glu Arg Pro Phe Arg Val Trp Leu Glu 
            580                 585                 590         


Gly Ala Thr Asp Ala Met Leu Ser Thr Trp Leu Thr Thr Ala Leu Asn 
        595                 600                 605             


Arg Ser Thr Thr Ala Ala Arg Asn Asn Pro Asp Val Ser Arg Lys Pro 
    610                 615                 620                 


Gln Asp Glu Arg Glu Leu Val Thr Ser Arg Ala Ala Lys Leu Pro Ile 
625                 630                 635                 640 


Ala Ile Gly Gly Lys Asp Gly Gln Gly Lys Asn Lys Ser Ile Arg Gln 
                645                 650                 655     


Phe Phe His Asp Leu Ser Ala Ala Thr Ala Ser Glu Met Arg Val Gln 
            660                 665                 670         


Arg Gly Tyr Ala Ser Asp Ala Glu Lys Ala Arg Glu Gln Ala Glu Tyr 
        675                 680                 685             


Ile Asp Glu Leu Leu Arg Asp Val Val Ala Leu Ala Phe Lys Asp Phe 
    690                 695                 700                 


Leu Asp Gly Lys Gly Leu Cys Trp Leu Leu Asp Ile Asp Pro Lys Gln 
705                 710                 715                 720 


Ala Leu Gln Pro Ile Arg Cys Cys Pro Thr Glu Asn Ile Gln Leu Pro 
                725                 730                 735     


Ala Ser Thr Leu Gln Ile Val Asn Trp Gln Pro Val Leu Tyr Phe Leu 
            740                 745                 750         


Leu His Leu Met Pro Val Gly Glu Val Ser Gln Leu Leu His Gln Leu 
        755                 760                 765             


Ala Lys Trp Glu Ile Leu Ala Lys Pro Glu Gln Ala Arg Asn Asp Thr 
    770                 775                 780                 


Glu Gly Ile Arg Ile Lys Ala Leu Gln His Thr Leu Lys Leu Tyr Leu 
785                 790                 795                 800 


Asp Met His Asp Ser Gln Tyr Thr Gly Asp Asp Ala Met Pro Thr Val 
                805                 810                 815     


Glu Arg Asp Val Leu Thr Thr Phe Ser Ser Phe Tyr Glu Asn Pro Arg 
            820                 825                 830         


Val Phe Ala Gln Val Phe Glu Asn Gln Gly Asn Gly Arg Glu Arg Ala 
        835                 840                 845             


Gln Tyr Leu Pro Gln Arg Gly Leu Arg Glu Ile Arg Arg Phe Gly His 
    850                 855                 860                 


Thr Pro Val Leu Gln Thr Leu Val Lys Lys Lys Ile Thr Ala Glu Asp 
865                 870                 875                 880 


Val Ser Arg Cys Leu Thr Ala Glu Ala Pro Leu Lys Asn Gly Ile Tyr 
                885                 890                 895     


Ser Val Val Ala Glu Ala Gln Ser Gln Arg Glu Ala Leu His Ala Gln 
            900                 905                 910         


Trp Val Lys Glu Arg Lys Gln Phe Glu Trp Tyr Gln Asp Tyr Ala Ala 
        915                 920                 925             


Ala Leu Lys Lys Val Val Ala His Arg Gln Asp Ser Asn His Ile Arg 
    930                 935                 940                 


Leu Val Asp His Val Ala Ala His Arg Ile Val Met Lys Val Leu Ala 
945                 950                 955                 960 


Arg Leu Ala Asp Phe Ser Gly Leu Phe Glu Arg Asp Leu Thr Phe Val 
                965                 970                 975     


Thr Leu Ala Thr Leu His Glu His Gln Leu Lys Pro Glu Asp Phe Phe 
            980                 985                 990         


Val Thr Asp Asn Pro Pro Lys Tyr  Asn Lys Lys Gly Lys  Met Glu Asp 
        995                 1000                 1005             


Asp Gly  Leu Thr Leu Phe Lys  Lys Gly Gln Ile Ile  Glu Ala Met 
    1010                 1015                 1020             


Gly Lys  Val Gln Val Ser Arg  Asn Ala Val Lys Gln  Ala Ile Val 
    1025                 1030                 1035             


Gly Arg  Val Asn Leu Asp Leu  Tyr Arg Ser Ile Arg  Asn Asp Phe 
    1040                 1045                 1050             


Ala His  Phe Asn Met Leu Tyr  Gly Lys Gln Arg Thr  Thr Glu Ser 
    1055                 1060                 1065             


Pro Ser  Asn Lys Met Leu Arg  Cys Ser Val Ala Met  Gly Leu Asn 
    1070                 1075                 1080             


Val Thr  Cys Trp Val Asn Cys  Ala Arg Asp Leu Met  Ser Tyr Asp 
    1085                 1090                 1095             


Arg Lys  Leu Lys Asn Ala Val  Ser Gln Ser Ile Met  Glu Leu Leu 
    1100                 1105                 1110             


Glu Arg  Glu Gly Phe Ile Leu  Thr Trp Glu Met Asn  Ser His His 
    1115                 1120                 1125             


Gln Leu  Cys Asn Ala Thr Leu  Glu Ser Arg Val Val  His His Leu 
    1130                 1135                 1140             


Gly Asp  Lys Lys Phe Pro Leu  Lys Glu Asp Lys Arg  Ala Phe Cys 
    1145                 1150                 1155             


Arg Ile  Thr Glu Ser Leu His  Ser Asp Ala Phe Val  Arg Met Leu 
    1160                 1165                 1170             


Ala Val  Ala Phe Gly Gly Ala  Ala His Pro Asn Gln  Asp Ile Gly 
    1175                 1180                 1185             


Thr Leu  Asp Leu Gln Thr Val  Asn Trp Glu Gly Ala  Lys Ala Lys 
    1190                 1195                 1200             


Trp Ala  Gly Ser Gln 
    1205             


<210>  765
<211>  1373
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  765

Met Ala Lys His Leu Arg Pro Ile Gly Glu Ser Tyr Thr Asp Phe Leu 
1               5                   10                  15      


Asp Glu Thr Glu Phe Val Arg Leu Gly Arg Gly Leu His Arg Gly His 
            20                  25                  30          


His Gly Val Gln Ile Pro Pro Thr Glu Leu Pro Ser Tyr Leu Ala Glu 
        35                  40                  45              


Tyr Arg Lys Ala Leu Met Arg Gln Val Val Ala Val Leu Asp Lys Val 
    50                  55                  60                  


Val Gly Lys Arg Arg Arg Leu Ser Gly Met His Pro Glu Ala Tyr Arg 
65                  70                  75                  80  


Asp Arg Val His Leu Ala Glu Ala Leu Trp Val Arg Leu Val Ala Arg 
                85                  90                  95      


Val Lys Glu Ile Gly Thr Pro Pro Asp Pro Ser Glu Leu Leu Asp Leu 
            100                 105                 110         


Arg Arg Met Trp Asn Ala Lys Ala His Pro Tyr Ala Glu Tyr Asp Val 
        115                 120                 125             


Val Pro Arg Ala Pro Leu Asn Asp Gly Asn Gly Gln Lys Ile Leu Glu 
    130                 135                 140                 


Cys Arg Glu Val Asp Asp Pro Lys Ile Glu Arg Ser Asp Phe Glu Gly 
145                 150                 155                 160 


Arg Trp His Gly Arg Phe Trp Gln Ser Glu Pro Gly Pro Val Asp Tyr 
                165                 170                 175     


Asn Ala Ile Ala Asp Arg Ile Phe Ala His Leu Phe Asp Gln Glu Ala 
            180                 185                 190         


Val Ile Gly Gly Gly Pro Arg Arg Glu Gly Asn Val Thr Val Pro Asp 
        195                 200                 205             


Glu Asp Ile Asn Gly Gln Pro Gly Pro Ala Thr Gly Lys Gly Leu Ile 
    210                 215                 220                 


Ile Ala Arg Gly Gln Ser Ile Val Lys Ser Ala Ser Asp Pro Arg Arg 
225                 230                 235                 240 


Ser Ser Lys Lys Val Gln Arg Thr Trp Asp Lys Ala Val Glu Arg Arg 
                245                 250                 255     


Tyr Phe Gly Asp Asp Gly Lys Gly Gly Ser Asp Ile Ala Lys Ala Ile 
            260                 265                 270         


Tyr Glu Glu Leu Gly Asp Pro Ala Thr Leu Ala Asp Pro Ile Tyr Ala 
        275                 280                 285             


Ser Trp Phe Gly Ser Arg Leu Tyr Asp His Phe Gly Ser Phe Lys Asn 
    290                 295                 300                 


Ser Leu Pro Leu Glu Leu Lys Asp Pro Phe Lys Glu Gln Ile Trp Ala 
305                 310                 315                 320 


Leu His Asn Ser Val Arg Gln Phe Tyr Gln Arg Met Ala Lys Ser Asp 
                325                 330                 335     


Arg Phe Arg Leu Ala Leu Gln Asn Ala Arg Ser Glu Val Pro Asp Arg 
            340                 345                 350         


Ser Glu Leu Leu Ala Leu Leu Pro Lys Asp His Asp His Leu Leu Leu 
        355                 360                 365             


Val Leu Gly Gly Lys Lys Lys Asn Ala Glu Met Ser Glu Leu Ile Arg 
    370                 375                 380                 


Leu Gly Lys Leu Phe Val His Ala Ser Asp Val Leu His Asp Phe Asp 
385                 390                 395                 400 


Ala Asn Asp Ala Ala Ala Leu Asp Ala Phe Lys Arg Arg Met Ser Phe 
                405                 410                 415     


Leu Ala Thr Ser Ile Gly Gln Ser Glu Ile Lys Gln Thr Glu Thr Phe 
            420                 425                 430         


Ala Arg Thr Trp Arg Gly Ala Val Gly Leu Thr Leu Arg Thr Val Lys 
        435                 440                 445             


Gly Leu Ala Asp Pro Arg Gly Ile Ile Gly Thr Pro Asp Asn Arg Asp 
    450                 455                 460                 


Leu Gly Thr Ala Gly Pro Met Lys Asp Ala Phe Asn Lys Phe Asp Gln 
465                 470                 475                 480 


Pro His Phe Gln Gln His Met Thr Ile Ile Phe Gly Asn Lys Glu Leu 
                485                 490                 495     


Gln Ala Glu Gly Asn Pro Thr Arg Ser Ser Val Phe Thr Ala Asn Gly 
            500                 505                 510         


Asp Lys Asp His Gln Ala Glu Leu Leu Trp Gly Phe Leu Cys Val Val 
        515                 520                 525             


Arg Ser Val Arg Asn Arg Thr Asn His Tyr Asn Val Arg Arg Ala Leu 
    530                 535                 540                 


Leu Arg Leu Leu Asp Glu Gly Ile Val Ser Pro Met Pro Ser Asp Pro 
545                 550                 555                 560 


Lys Lys Glu Arg Val Glu Asn Arg Asn Leu Cys Thr Val Ser Pro Thr 
                565                 570                 575     


Ala Leu Glu Ala Phe Arg Arg Leu Leu Asn Phe Asp Leu Ala Ile Gln 
            580                 585                 590         


Lys Glu Ala Val Arg Thr Ala Leu Glu Gln Ala Lys Ala Ser Glu Phe 
        595                 600                 605             


Val Glu Glu Gly Lys Leu Arg Gly Leu Val Ser Glu Leu Ala Gly Thr 
    610                 615                 620                 


Glu Asp Met Pro Ala Leu His Ile Pro Arg Phe Ser Ala Val Met Asp 
625                 630                 635                 640 


Lys Val Arg Arg Leu Ala Asp Asn Arg Asp Val Gly Leu Asp Pro Ile 
                645                 650                 655     


Leu Ser Thr Leu Gln Arg Ser Leu Pro Pro Thr Asp Lys Gln Ala Glu 
            660                 665                 670         


Ser Asp Ala Ala Arg Cys Arg Tyr Arg Leu Leu Leu Glu Leu Tyr Lys 
        675                 680                 685             


Ser Gly Phe Arg Ser Trp Phe Ser Gly Ile Gln Ser Asn Glu Glu Asn 
    690                 695                 700                 


Asn Arg Glu Ile Cys His Trp Ala Val Lys Gln Val Gly Arg Ala Lys 
705                 710                 715                 720 


Asp Ala Arg Lys Ser Glu Tyr Asp Lys Lys Thr Lys Arg His Tyr Arg 
                725                 730                 735     


Ser Pro Asn Ser Leu Ile Asp Asp Leu Gly Leu Asp Lys Phe Asp Asp 
            740                 745                 750         


Leu Thr Asp Leu Leu Glu Ala Leu Ala Ser Gln Ser Thr Arg Glu His 
        755                 760                 765             


Asp Gln Asn Leu Lys Tyr Val Pro Asp Ala Arg Val Gln Ser Gln Met 
    770                 775                 780                 


Ser Asn Arg Ile Glu Glu Phe Arg Gln Glu Leu Phe Ala His Ile Phe 
785                 790                 795                 800 


Thr Lys Tyr Leu Asp Thr His Asp Phe Gly Trp Ile Gly Ala Ile Glu 
                805                 810                 815     


Val Arg Arg Glu Ala Cys Asp Leu Ala Asp Val Val Ser Ala Phe Glu 
            820                 825                 830         


Val Arg Asp Gln Lys Phe Asp Ala Asp Trp His Ser Gln Phe Tyr Ala 
        835                 840                 845             


Trp Leu Tyr Met Val Pro Pro Ile Glu Ala Ser Arg Leu Arg His Gln 
    850                 855                 860                 


Met Arg Lys Ser Ala Val Met Asp Asp Lys Trp Ser Thr Thr Leu Glu 
865                 870                 875                 880 


Leu Thr Ser Gly Asp Arg Lys Thr Arg Asp Asp His Ala Gln Asp Val 
                885                 890                 895     


Leu Ala Asp Met Asp Arg Leu Phe Ser Leu Tyr Thr Lys Val Gln Ala 
            900                 905                 910         


Ala Gly Phe Asn Gly Gln Glu His Glu Ser Ala Leu Gly Ser Lys Ser 
        915                 920                 925             


Leu Phe Tyr Glu Asp Gly Asn Gln Phe Asp Glu Val Tyr Ser Pro Asp 
    930                 935                 940                 


Thr Glu Thr His Asn Lys Thr Phe Pro Gly Thr Arg Arg Gly Leu Arg 
945                 950                 955                 960 


Gln Leu Val Arg Tyr Ala His Leu Pro Ala Leu Glu Gly Val Phe Lys 
                965                 970                 975     


Lys His Arg Ile Thr Lys Ala Glu Val Glu Thr Phe Val Ala Leu Tyr 
            980                 985                 990         


Asp Glu Asn Arg Arg Asp Pro Gly  Ser Val Ala His Met  Leu Arg Arg 
        995                 1000                 1005             


Glu Lys  Leu Arg Thr Glu Ile  Leu Arg Ser Ile His  Asp Gly Pro 
    1010                 1015                 1020             


Lys Pro  Lys Asp Lys Asp Phe  Trp Pro Lys Leu Glu  Ala Lys Cys 
    1025                 1030                 1035             


Leu Glu  Tyr Arg Thr Val Ala  Thr Glu Thr Ala Ile  Tyr Asn Phe 
    1040                 1045                 1050             


Gln Ala  Asn Ala Ala Arg Leu  Asn Asp His Ala Arg  Leu His Gln 
    1055                 1060                 1065             


Ile Val  Met Arg Val Val Ala  Arg Leu Thr Asp Tyr  Ala Leu Ile 
    1070                 1075                 1080             


Trp Glu  Arg Asp Arg Leu Phe  Ala Phe Val Gly Met  Leu Tyr Arg 
    1085                 1090                 1095             


Gln Thr  Gly Gly Thr Gly Ile  Asn Pro Ala Met Arg  His Ala Glu 
    1100                 1105                 1110             


Lys Thr  Asn Ala Pro Pro Arg  Ile Gly Ile Leu Val  Ser Asp Ser 
    1115                 1120                 1125             


Ala Leu  Ala Lys Lys Leu Asn  Ser Asn Ser Ala Glu  Val Phe Ile 
    1130                 1135                 1140             


Pro Tyr  Leu Asp Thr Glu Thr  Gly Phe Asp Ala Pro  Arg Phe Asp 
    1145                 1150                 1155             


Asp Leu  Cys Thr Leu Leu Ser  His Glu His Ala Lys  Glu Phe Arg 
    1160                 1165                 1170             


Phe His  Phe Leu Glu Val Gly  Glu Glu Asn Ser Lys  Asp Glu Ala 
    1175                 1180                 1185             


Arg Arg  Leu Asn Glu Glu Thr  Met Gly His Arg Lys  Arg Pro Ala 
    1190                 1195                 1200             


Phe Lys  Arg Gly Thr Arg Arg  Gln Gly Ile Arg Asn  Asp Leu Ala 
    1205                 1210                 1215             


His His  Asn Val Leu Asp Leu  Ala Gly Gly Ala Gly  Pro Asn Leu 
    1220                 1225                 1230             


Thr Tyr  Val Val Asn Ala Val  Arg Ser Leu Leu Ser  Tyr Asp Arg 
    1235                 1240                 1245             


Lys Leu  Lys Asn Ala Val Pro  Lys Ser Ile Lys Arg  Ile Leu Gly 
    1250                 1255                 1260             


Glu Glu  Gly Leu Ile Ile Glu  Trp Gln Met Asn Tyr  Asp Arg Leu 
    1265                 1270                 1275             


Lys Lys  Pro Thr Val Tyr Pro  Asn Val Glu Thr His  Leu Thr Met 
    1280                 1285                 1290             


Val Pro  Pro Arg His Met Thr  Ala Pro Val Ser Phe  Thr Leu Pro 
    1295                 1300                 1305             


Arg Ala  Ser Val Arg Leu Ala  Ser Met Val Lys Ala  Val Phe Asp 
    1310                 1315                 1320             


Phe Gly  Ser Ser Gly Tyr Gly  Glu Glu Arg Met Ile  Gly Gly Arg 
    1325                 1330                 1335             


Thr Ala  Lys Gln Ala Val Tyr  Pro Asp Asp Phe Thr  Arg Arg Phe 
    1340                 1345                 1350             


Pro Gln  Thr Pro Met Gly Leu  Lys Gln Ala Thr Arg  Leu Val Phe 
    1355                 1360                 1365             


Ala Ser  Glu Asn Ser 
    1370             


<210>  766
<211>  1287
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  766

Met Arg Ile Gly Lys Val Gln Gly Arg Thr Phe Thr Gly Phe Asp Asn 
1               5                   10                  15      


Ala Arg Gly Lys Thr Leu Arg Arg Arg Leu Leu Thr Arg Pro Asp Asn 
            20                  25                  30          


Glu Ala Arg Ser Leu Ser Glu His Leu Ala His Asp Pro Lys Ala Leu 
        35                  40                  45              


Ile Gly Gln Ala Ile Ser Arg Ile Asp Thr Ile Tyr Gln Lys Pro Lys 
    50                  55                  60                  


Thr Gly Lys Pro Thr Pro Glu Gln Phe Gly His Arg Asp Thr Leu Gly 
65                  70                  75                  80  


Trp Ala Tyr Trp Lys Leu Leu Val Ala Ser Tyr Pro Glu Val Glu Gly 
                85                  90                  95      


His Arg Asp Leu Phe Val Arg Arg Leu His Pro Tyr Gly Asp Thr Pro 
            100                 105                 110         


Pro Lys Ser His Gly Gln Lys Glu Gly Glu His Gln Lys Gly Gly Lys 
        115                 120                 125             


Pro Gln Leu Glu Gly Arg Trp His Gly Val Met Ala Gln His Gly Lys 
    130                 135                 140                 


Asn Pro Asp Gln Ile Ala Ala Arg Leu Phe Asp His Leu His Asn Ser 
145                 150                 155                 160 


Glu Leu Arg Phe Gly Gly Thr Ala Ser Gly Glu Pro Arg Thr Arg Pro 
                165                 170                 175     


Gly Lys Glu Ala Thr Pro Thr Gly Leu Ile Gly Ala Arg Ala Lys Thr 
            180                 185                 190         


Ile Glu His Ser Val Leu Pro Arg Asp Ala Lys Arg Phe Val Ala Glu 
        195                 200                 205             


Trp Arg Gly Glu Asp Gln Glu Arg Tyr Ala Gly Ala Arg Asp Ile Ala 
    210                 215                 220                 


Ala Ala Ile Ser Ala Gly Leu Asn Asp Lys Asp Gln Lys Ser Gly Ser 
225                 230                 235                 240 


Gly Arg Lys Ser Ala Val Ile Gly Lys Leu Leu Ser Asp His Leu Glu 
                245                 250                 255     


Thr Leu Thr Gly Asn Arg Lys Cys Arg Phe Asp Pro Lys Ser Thr Ala 
            260                 265                 270         


Glu Thr Leu Glu Leu Arg Asp Gly Glu Ser Val Asp Asp Arg Arg Arg 
        275                 280                 285             


Ile Leu Glu Leu His Ala Glu Val Lys Ala Thr Tyr Lys Arg Met Ala 
    290                 295                 300                 


Ala Trp Lys Pro Ala Lys Leu Pro Arg Asn Ser Asp Glu Leu Phe Arg 
305                 310                 315                 320 


Leu Val Arg Gln Gln Ala Asp Asn Arg Ile Leu Asn His Leu Val Arg 
                325                 330                 335     


Val Gly Arg Ile Ser Val Tyr Ser Glu Gln Ser Asp Ala Leu Ser Glu 
            340                 345                 350         


Ser Gln Phe Trp Thr Ser Gly Gly Gln Thr Gln Ile Lys Glu Ser Glu 
        355                 360                 365             


Val Phe Ala Arg Leu Trp Ile Gly Ala Ile Ser Arg Ala Ser Tyr Ser 
    370                 375                 380                 


Met Lys Ala Trp Leu Glu Pro Glu Gly Thr Val Phe Asn Pro Ser Ile 
385                 390                 395                 400 


Asn Asp Phe Asp Val Thr Ser Ser His Asn Thr Asn Arg Ile Leu Glu 
                405                 410                 415     


Asp Ser Gly Arg Leu Ser Asn Ala Met Ala Arg Arg Ala Ile Tyr Phe 
            420                 425                 430         


Gly Glu Thr Pro Glu Phe Asp Ala Leu Gly Glu Glu Asp Gln Arg Val 
        435                 440                 445             


Leu Val Lys Lys Cys Leu Asp Ala Leu Ser Ala Cys Arg Asn Arg Thr 
    450                 455                 460                 


Phe His His Gly Gln Arg Ala Lys Phe Leu Lys Glu Val Arg Lys Gly 
465                 470                 475                 480 


Leu Lys Glu Lys Glu Ala Asp Ser Ala Gly Pro Ala Ala Trp Glu Gly 
                485                 490                 495     


Ile Arg Glu Val Ile Gln Ala Asp Ala Arg Asn Leu Gly Ala Arg Leu 
            500                 505                 510         


Leu Gln Asp Leu Thr Gly Ala Lys Val His Ser Phe Ala Thr Asp Pro 
        515                 520                 525             


Glu Phe Arg His Leu Tyr Glu Ser Val Ala Ala Thr Leu Thr Ala Gly 
    530                 535                 540                 


Gly Glu Leu Glu Ala Ala Leu Pro Arg Leu Lys Asn Val Leu Lys Arg 
545                 550                 555                 560 


Ala Glu Gly Val Arg Cys Tyr Leu Asp Thr Pro Ser Gln Arg Arg Glu 
                565                 570                 575     


Gly Asp Glu Ser Leu Ile Ala Arg Leu Pro Val Ala Pro Val Pro Arg 
            580                 585                 590         


Glu Leu Asp Asp Ala Ala Thr Lys Ala Arg His Ser Ala Leu Leu Arg 
        595                 600                 605             


Leu Tyr Asp Gly Pro Phe Arg Pro Trp Ala Thr Glu Leu Arg Gly Glu 
    610                 615                 620                 


Arg Leu Ser Asp Tyr Ala Ala Arg Ala Lys Arg Leu Ala Thr Arg Leu 
625                 630                 635                 640 


Ala Lys Ser Thr Asn Thr Ala Ser Pro Tyr Pro Asp Ser Val Glu Gly 
                645                 650                 655     


Arg Ser Val Arg Leu Arg Asp Pro Ile Thr Ala Asp Thr Ala Pro Glu 
            660                 665                 670         


Thr Leu Lys Thr Tyr Leu Ser Ala Leu Thr Ala Glu Thr Ala Thr Glu 
        675                 680                 685             


Phe Arg Val Gln Lys Gly Tyr Glu Ser Asp Gly Glu Lys Ala Lys Glu 
    690                 695                 700                 


Gln Ala Glu Phe Ile Glu Asp Phe Arg Arg Asp Met Ile Ala Leu Ala 
705                 710                 715                 720 


Phe Gln Asp Phe Ile Arg Asp His Gly Phe Ala Trp Leu Leu Asp Ile 
                725                 730                 735     


Ala Ser Lys Ala Glu Pro Ser Asn Asp Ala Pro Asn Leu Pro Asp Pro 
            740                 745                 750         


Val Asp Thr Gly Lys Asp Thr Val Phe Glu Asp Trp Gln Ala Leu Leu 
        755                 760                 765             


Tyr Leu Phe Leu His Phe Val Pro Ala Asp Asp Val Ser Gln Leu Leu 
    770                 775                 780                 


His Gln Leu Arg Lys Trp Asp Ala Leu Gln Asp Lys Tyr Glu Leu Ala 
785                 790                 795                 800 


Glu Pro Gly Glu Thr Leu Gly Gln Thr Lys Ala Asp Thr Arg Lys Ile 
                805                 810                 815     


Val Gly Gln Phe Arg Asp Cys Leu Thr Leu Phe Leu Lys Thr Gly Asp 
            820                 825                 830         


Ala Arg Phe Asp Gly Glu Gly Val Glu Leu Pro Leu Ser Asp Phe Gln 
        835                 840                 845             


Glu Leu Phe Glu Ser Pro Ala Thr Phe Lys Glu Leu Phe Leu Ala Glu 
    850                 855                 860                 


Pro Ala Glu Asn Asp Ala Ser Glu Thr Asp Asp Gln Asp Ala Pro Gly 
865                 870                 875                 880 


Glu Lys His Arg Val Thr Arg Thr Arg Arg Gly Leu Arg Gln Ile Leu 
                885                 890                 895     


Arg Tyr Asn His Met Pro Val Leu Arg Asp Leu Phe Leu Ala His Lys 
            900                 905                 910         


Val Thr Asp Ala Glu Val Asp Gly Leu Gln Ala Leu Glu Val Asp Asp 
        915                 920                 925             


Pro Gln Thr Gly Glu Ser Gln Ile Gly Ala Ala Gln Arg Ile Arg Thr 
    930                 935                 940                 


Glu Ile His His His Thr Ser Asn Asp Lys Gln Ile Ser Glu Ala Lys 
945                 950                 955                 960 


Val Glu Glu Tyr Arg Arg Ala Leu Ser Thr Ile Glu Arg His Arg Phe 
                965                 970                 975     


Leu Val Gly Arg Val Tyr Leu Gly Asp His Ile Arg Val His Lys Leu 
            980                 985                 990         


Met Met Asp Val Met Gly Arg Leu  Val Asp Phe Ala Gly  Ala Trp Glu 
        995                 1000                 1005             


Arg Glu  Ala Ala Asp Gly Asp  Arg Lys Gly Phe Ile  Ser Arg Ala 
    1010                 1015                 1020             


Ile Ala  Leu Pro Glu Val Ala  Glu Gly Tyr Ala Ala  Asp Arg Leu 
    1025                 1030                 1035             


Lys Thr  Val Ala Arg Arg Val  Leu Asp Asp Gly Glu  Ala Arg Arg 
    1040                 1045                 1050             


Ile Arg  Asn Asp Leu Gly His  Phe Asn Asp Leu Ala  Pro Thr Ser 
    1055                 1060                 1065             


Gly Pro  Ala Asn Leu Thr Phe  Val Val Asn Arg Ala  Arg Arg Met 
    1070                 1075                 1080             


Met Arg  His Asp Arg Lys Arg  Lys Asn Ala Val Thr  Lys Ser Val 
    1085                 1090                 1095             


Ile Glu  Ile Leu Asn Arg Gln  Gly Leu Gly Ile Glu  Trp Thr Met 
    1100                 1105                 1110             


Arg Asn  His Glu Leu Cys Glu  Ala Lys Leu Trp Gln  Asn Pro Val 
    1115                 1120                 1125             


Lys His  Leu Gly Phe Ala Thr  Leu Glu Gly Arg Gly  Lys Lys Trp 
    1130                 1135                 1140             


Arg Arg  Pro Phe Glu Ala Arg  Tyr Gly Asp Ala Tyr  Met Ala Met 
    1145                 1150                 1155             


Val Ala  Gln Leu Phe Asp Gly  Thr Val Thr Ser Pro  Pro Ala Lys 
    1160                 1165                 1170             


Gly Pro  Pro Gln Ser Gly Lys  Ser Gly Gly Lys Pro  Gly Lys Gly 
    1175                 1180                 1185             


Ala Glu  Gly Gly Ala Lys Glu  Lys Ser Arg Ser Pro  Thr Arg Met 
    1190                 1195                 1200             


Glu Glu  Gly Gly Val Tyr Glu  Gly Arg Val Ala Lys  Ala Lys Ser 
    1205                 1210                 1215             


Asp Lys  Gly Phe Gly Phe Leu  Leu Val Glu Gly Ala  Gln Glu Glu 
    1220                 1225                 1230             


Ile Phe  Leu His Ile Tyr Gly  Ile Ser Gly Asn Arg  Pro Ala Arg 
    1235                 1240                 1245             


Ile Glu  Asn Gly Gln Arg Tyr  Arg Phe Thr Leu Gly  Ile Asp Arg 
    1250                 1255                 1260             


Asp Arg  Glu Arg Arg Lys Glu  Arg Ala Trp Val Ala  Arg Glu Ala 
    1265                 1270                 1275             


Val Arg  Ile Asp Glu Asn Arg  Ser Lys 
    1280                 1285         


<210>  767
<211>  1175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  767

Met Lys Ile Thr Lys Arg Lys Trp Glu Asp Val Pro Pro Leu Phe Phe 
1               5                   10                  15      


His Arg Asp Lys Asp Ser Gly Arg Leu Ile Arg Gln Asp Asp Arg Glu 
            20                  25                  30          


His Asp Tyr Thr Asp Glu Leu Phe Arg Lys Thr Thr Val Asp Ser Ile 
        35                  40                  45              


Phe Ile Arg Ser Leu Gln Asn Arg Leu Leu Arg Ser Gln Asp Lys Glu 
    50                  55                  60                  


Gly Asn Lys Ile Gly Arg Asn Glu Ile Thr Glu Leu Val Glu Asn Leu 
65                  70                  75                  80  


Cys Lys Gly Ala Glu Ile Gln Lys Ser Ile Asp Glu Ile Lys Asp Ser 
                85                  90                  95      


Lys Ser Asn Val Lys Ala Leu Cys Asp Lys Thr Leu Thr Asp Tyr Gly 
            100                 105                 110         


Lys Ser Phe Ala Ala Glu Glu Gly Arg Thr Thr Leu Tyr Glu Ala Ile 
        115                 120                 125             


Leu Asn Leu Ala Lys Gly Asn Ala Ile Gln Lys Ala Met Ala Glu Ala 
    130                 135                 140                 


Glu Leu Lys Gln Ile His Glu Ala Leu Lys Lys Glu Lys Glu Asp Arg 
145                 150                 155                 160 


Ile Asn Arg Val Gln Asn Ser Ile Lys Asn Asn Lys Ile Pro Leu Lys 
                165                 170                 175     


Val Asn Glu Asp Gly Thr Ile Ser Ala Asn Asn Asp Arg Ala Ser Trp 
            180                 185                 190         


Leu Leu Glu Leu Leu Lys Pro Val Ala Ser Glu His Asp Lys Gly Asp 
        195                 200                 205             


Arg Tyr Pro Val Leu Thr Glu Met Glu Gly Ile Val Ser Phe Asp Lys 
    210                 215                 220                 


Leu Cys Glu Glu Val Arg Asn Lys Ile His Gly Arg Lys Gly Arg Thr 
225                 230                 235                 240 


Arg Ser Ile Ala Met Ser Val Asp Glu Ala Val Lys Glu Tyr Leu Lys 
                245                 250                 255     


Glu Leu Trp Lys Lys His Ala Asp Arg His Arg Asp Met Arg Tyr Tyr 
            260                 265                 270         


Phe Gln Ala Val Lys Glu Tyr Phe Lys Glu Asn Phe Pro Ile Arg Thr 
        275                 280                 285             


Lys Gln Lys Gly Ala Gly Ile Arg Gln Ser Leu Leu Lys Glu Asp Thr 
    290                 295                 300                 


Val Val Ala Arg Leu Leu Asp Pro Lys His Met Ala Lys Ala Val Arg 
305                 310                 315                 320 


Arg Lys Leu Ile Asn Gln Ser Ile Gln Met His Ile Leu Tyr Gly Lys 
                325                 330                 335     


Leu Tyr Glu Tyr Cys Cys Arg Glu Asp Arg Asn Leu Pro Val Asn Ser 
            340                 345                 350         


Glu Thr Leu Gln Leu Ile Gln Val Leu Glu Ala Phe Lys Lys Gln Leu 
        355                 360                 365             


Met Thr Ala Val Leu Trp Ser Val Ser Arg Leu Cys Tyr Phe Tyr Glu 
    370                 375                 380                 


Phe Tyr Ser Gly Asp Ile Leu Leu Ala Glu Glu Tyr Arg Arg Asp Phe 
385                 390                 395                 400 


Leu Asn Gln Lys Asn Asp His Lys Asp Ile Gln Ala Cys Lys Glu Lys 
                405                 410                 415     


Leu Gln Asp Phe Phe Pro Leu Ala Glu Leu Gln Glu Lys Ile Arg Glu 
            420                 425                 430         


Cys Ala Asp Lys Asp Ile Asn Asn Ile Lys Asp Lys Ile Thr Asn Asp 
        435                 440                 445             


Val Leu Ala Cys Asn Asn Leu Leu Glu Glu Cys Val Phe Cys Ile Ser 
    450                 455                 460                 


Lys Leu Arg Asn Asn Ile Phe His Tyr Lys Asn Leu Ser Phe Thr Gln 
465                 470                 475                 480 


Ala Leu Lys His Ile Ala Asn Glu Ile Lys Glu Glu Asp Ile Pro Ile 
                485                 490                 495     


Ile Leu Arg Leu Tyr Lys Gln Asp Cys Glu Asn Val Asn Lys Ala Phe 
            500                 505                 510         


Ala Asn Arg Ile Ser Ser Met Asn Leu Pro Leu Tyr Tyr Ser Thr Glu 
        515                 520                 525             


Phe Leu Leu Arg Ile Phe Lys Lys Gln Gly Ala Glu Leu Ser Leu Tyr 
    530                 535                 540                 


Ser Thr Lys Asn Gln Met Thr Pro Ser Phe Lys Arg Val Tyr Glu Arg 
545                 550                 555                 560 


Gly Lys Asn Leu Arg Leu Glu Tyr Glu Arg Glu Pro Met Arg Ser Asn 
                565                 570                 575     


Ile Ala Asn Glu Tyr Asp Lys Asp Pro Gln Ser Asp Tyr Trp Met Arg 
            580                 585                 590         


Trp Phe Ser Gln Phe Ala Thr Gly Thr Val Asp Thr Asn Ala Gly Ile 
        595                 600                 605             


Lys Gly Glu Met Glu Asp Tyr Pro His Ala Ser Val Asn Leu Gly Ile 
    610                 615                 620                 


Glu Ile Glu Ala Gly Thr Asn Ile Asp Ala Gln Arg Ala Met Arg Asn 
625                 630                 635                 640 


Leu Leu Gln Leu Ile Tyr Lys His His Phe Leu Pro Glu Val Gln Lys 
                645                 650                 655     


Asp Glu Thr Val Val Thr Asp Val Ile Pro Lys Val Leu Glu Arg Asn 
            660                 665                 670         


Arg Lys Leu Ser Glu Val Arg Asn Arg Ser Asp Lys Thr Tyr Gly Tyr 
        675                 680                 685             


Lys Glu Ile Glu Glu Leu Cys Lys Lys Asn Lys Gly Lys Lys Asp Ser 
    690                 695                 700                 


Leu Ser Glu Leu Met Lys Asp Leu Gln Arg Lys Val Ser Glu Thr Glu 
705                 710                 715                 720 


Lys Glu Lys Arg Glu Leu Ala Arg Glu Lys Thr Asp Tyr Ala Gln Arg 
                725                 730                 735     


Phe Ile Leu Asp Ile Phe Ala Glu Ala Phe Cys Asn Phe Met Asp Glu 
            740                 745                 750         


Arg Tyr Glu Asp Glu Tyr Gln Glu Ile Met Ser Pro Ile Lys Asn Glu 
        755                 760                 765             


Glu Glu Ala Lys Lys Trp Thr Glu Met Phe Thr Asp Lys Ala Asp Lys 
    770                 775                 780                 


Asp Asn Lys Asp Lys Leu Leu Val Leu Lys Thr Ser Phe Asp Lys Asp 
785                 790                 795                 800 


Asn Val Glu Lys Tyr Leu Leu Ala Leu Tyr Pro Leu Met Arg Leu Leu 
                805                 810                 815     


Asp Asp Lys Glu Leu Ser Glu Leu Gln Gln Gln Met Leu Arg Phe Arg 
            820                 825                 830         


Ala Ser Val Ser Gly Trp Gln Gly Gly Thr Asp Phe Ser Glu Asp Ile 
        835                 840                 845             


Ala Met Ala Glu Lys Ile Glu Glu Leu Ala Glu Leu Val Lys Leu Thr 
    850                 855                 860                 


Glu Pro Glu Ser Gln Tyr Ala Glu Glu Ala Trp Lys Asn Arg Ala Ile 
865                 870                 875                 880 


Gly Val Phe Glu Gln Phe Val Glu Gly Lys Met Ala Glu Tyr Gly Thr 
                885                 890                 895     


Phe Tyr Ile Gln Asn Asp Ser Leu Thr Gln Val Pro Arg Gly Asn Met 
            900                 905                 910         


Arg Lys Leu Leu Arg Ser Gly Val Ile Gly Val Tyr Asn Lys Val Leu 
        915                 920                 925             


Ala Ser Cys Lys Gln Ala Thr Lys Ala Asp Tyr Gly Ala Tyr Ser Gly 
    930                 935                 940                 


Asp His Trp Ser Ile Glu Asp Pro Asp Gly Asn Pro Ile Lys Ser Ala 
945                 950                 955                 960 


Glu Gln Ala Gln Ala Leu Leu Gln Arg Leu His Lys Lys Tyr Thr Glu 
                965                 970                 975     


Ser Pro Ser Gln Phe Ser Asp Asp Asp His Lys Leu Tyr Asp Lys Thr 
            980                 985                 990         


Leu Arg Gln Leu Asp Ala Tyr Asn  Arg Ala Met Lys Asn  Leu Ser Phe 
        995                 1000                 1005             


Gly Ser  Leu Tyr Glu Ile Cys  Arg Ile His Met Glu  Thr Leu Ser 
    1010                 1015                 1020             


Arg Trp  Val Gly Phe Val Gln  Asp Trp Glu Arg Asp  Met Tyr Phe 
    1025                 1030                 1035             


Leu Leu  Leu Ala Trp Thr Lys  Gln Gly Lys Leu Leu  Asn Val Thr 
    1040                 1045                 1050             


Glu Thr  Asp Val Ile Glu Ile  Phe Glu Lys Gly Ser  Val Ile Tyr 
    1055                 1060                 1065             


Lys Met  Asn Lys Lys Leu Lys  Asn Gly Asp Arg Tyr  Ala Phe Thr 
    1070                 1075                 1080             


Ser Ile  Tyr Arg Asn Asn Asn  Asp Glu Lys Leu Glu  Phe Leu Gln 
    1085                 1090                 1095             


Ile Arg  Asn Phe Ile Ala His  Leu His Leu Leu Arg  Lys Ser Glu 
    1100                 1105                 1110             


Trp Lys  Gly Asp Lys Lys Ala  Gly Tyr Ser Val Ile  Glu Asp Tyr 
    1115                 1120                 1125             


Ile Asn  Lys Leu Arg Phe Leu  Leu Ser Tyr Asp Gln  Lys Arg Met 
    1130                 1135                 1140             


Asn Ala  Val Thr Lys Ala Met  Gln Gln Ile Phe Glu  Lys His Lys 
    1145                 1150                 1155             


Val Ile  Val Lys Phe Met Val  Glu Lys Gly Gly Cys  Leu Arg Leu 
    1160                 1165                 1170             


Arg Met  
    1175 


<210>  768
<211>  1175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  768

Met Lys Ile Thr Lys Arg Lys Trp Glu Asp Val Pro Pro Leu Phe Phe 
1               5                   10                  15      


His Arg Asp Lys Asp Ser Gly Arg Leu Ile Arg Gln Asp Asp Arg Glu 
            20                  25                  30          


His Asp Tyr Thr Asp Glu Leu Phe Arg Lys Thr Thr Val Asp Ser Ile 
        35                  40                  45              


Phe Ile Arg Ser Leu Gln Asn Arg Leu Leu Arg Ser Gln Asp Lys Glu 
    50                  55                  60                  


Gly Asn Lys Ile Gly Arg Asn Glu Ile Thr Glu Leu Val Glu Asn Leu 
65                  70                  75                  80  


Cys Lys Gly Ala Glu Ile Gln Lys Ser Ile Asp Glu Ile Lys Asp Ser 
                85                  90                  95      


Lys Ser Asn Val Lys Ala Leu Cys Asp Lys Thr Leu Thr Asp Tyr Gly 
            100                 105                 110         


Lys Ser Phe Ala Ala Glu Glu Gly Arg Thr Thr Leu Tyr Glu Ala Ile 
        115                 120                 125             


Leu Asn Leu Ala Lys Gly Asn Ala Ile Gln Lys Ala Met Ala Glu Ala 
    130                 135                 140                 


Glu Leu Lys Gln Ile His Glu Ala Leu Lys Lys Glu Lys Glu Asp Arg 
145                 150                 155                 160 


Ile Asn Arg Val Gln Asn Ser Ile Lys Asn Asn Lys Ile Pro Leu Lys 
                165                 170                 175     


Val Asn Glu Asp Gly Thr Ile Ser Ala Asn Asn Asp Arg Ala Ser Trp 
            180                 185                 190         


Leu Leu Glu Leu Leu Lys Pro Val Ala Ser Glu His Asp Lys Gly Asp 
        195                 200                 205             


Arg Tyr Pro Val Leu Thr Glu Met Glu Gly Ile Val Ser Phe Asp Lys 
    210                 215                 220                 


Leu Cys Glu Glu Val Arg Asn Lys Ile His Gly Arg Lys Gly Arg Thr 
225                 230                 235                 240 


Arg Ser Ile Ala Met Ser Val Asp Glu Ala Val Lys Glu Tyr Leu Lys 
                245                 250                 255     


Glu Leu Trp Lys Lys His Ala Asp Arg His Arg Asp Met Arg Tyr Tyr 
            260                 265                 270         


Phe Gln Ala Val Lys Glu Tyr Phe Lys Glu Asn Phe Pro Ile Arg Thr 
        275                 280                 285             


Lys Gln Lys Gly Ala Gly Ile Arg Gln Ser Leu Leu Lys Glu Asp Thr 
    290                 295                 300                 


Val Val Ala Arg Leu Leu Asp Pro Lys His Met Ala Lys Ala Val Arg 
305                 310                 315                 320 


Arg Lys Leu Ile Asn Gln Ser Ile Gln Met His Ile Leu Tyr Gly Lys 
                325                 330                 335     


Leu Tyr Glu Tyr Cys Cys Arg Glu Asp Arg Asn Leu Pro Val Asn Ser 
            340                 345                 350         


Glu Thr Leu Gln Leu Ile Gln Val Leu Glu Ala Phe Lys Lys Gln Leu 
        355                 360                 365             


Met Thr Ala Val Leu Trp Ser Val Ser Arg Leu Cys Tyr Phe Tyr Glu 
    370                 375                 380                 


Phe Tyr Ser Gly Asp Ile Leu Leu Ala Glu Glu Tyr Arg Arg Asp Phe 
385                 390                 395                 400 


Leu Asn Gln Lys Asn Asp His Lys Asp Ile Gln Ala Cys Lys Glu Lys 
                405                 410                 415     


Leu Gln Asp Phe Phe Pro Leu Ala Glu Leu Gln Glu Lys Ile Arg Glu 
            420                 425                 430         


Cys Ala Asp Lys Asp Ile Asn Asn Ile Lys Asp Lys Ile Thr Asn Asp 
        435                 440                 445             


Val Leu Ala Cys Asn Asn Leu Leu Glu Glu Cys Val Phe Cys Ile Ser 
    450                 455                 460                 


Lys Leu Arg Asn Asn Ile Phe His Tyr Lys Asn Leu Ser Phe Thr Gln 
465                 470                 475                 480 


Ala Leu Lys His Ile Ala Asn Glu Ile Lys Glu Glu Asp Ile Pro Ile 
                485                 490                 495     


Ile Leu Arg Leu Tyr Lys Gln Asp Cys Glu Asn Val Asn Lys Ala Phe 
            500                 505                 510         


Ala Asn Arg Ile Ser Ser Met Asn Leu Pro Leu Tyr Tyr Ser Thr Glu 
        515                 520                 525             


Phe Leu Leu Arg Ile Phe Lys Lys Gln Gly Ala Glu Leu Ser Leu Tyr 
    530                 535                 540                 


Ser Thr Lys Asn Gln Met Thr Pro Ser Phe Lys Arg Val Tyr Glu Arg 
545                 550                 555                 560 


Gly Lys Asn Leu Arg Leu Glu Tyr Glu Arg Glu Pro Met Arg Ser Asn 
                565                 570                 575     


Ile Ala Asn Glu Tyr Asp Lys Asp Pro Gln Ser Asp Tyr Trp Met Arg 
            580                 585                 590         


Trp Phe Ser Gln Phe Ala Thr Gly Thr Val Asp Thr Asn Ala Gly Ile 
        595                 600                 605             


Lys Gly Glu Met Glu Asp Tyr Pro His Ala Ser Val Asn Leu Gly Ile 
    610                 615                 620                 


Glu Ile Glu Ala Gly Thr Asn Ile Asp Ala Gln Arg Ala Met Arg Asn 
625                 630                 635                 640 


Leu Leu Gln Leu Ile Tyr Lys His His Phe Leu Pro Glu Val Gln Lys 
                645                 650                 655     


Asp Glu Thr Val Val Thr Asp Val Ile Pro Lys Val Leu Glu Arg Asn 
            660                 665                 670         


Arg Lys Leu Ser Glu Val Arg Asn Arg Ser Asp Lys Thr Tyr Gly Tyr 
        675                 680                 685             


Lys Glu Ile Glu Glu Leu Cys Lys Lys Asn Lys Gly Lys Lys Asp Ser 
    690                 695                 700                 


Leu Ser Glu Leu Met Lys Asp Leu Gln Arg Lys Val Ser Glu Thr Glu 
705                 710                 715                 720 


Lys Glu Lys Arg Glu Leu Ala Arg Glu Lys Thr Asp Tyr Ala Gln Arg 
                725                 730                 735     


Phe Ile Leu Asp Ile Phe Ala Glu Ala Phe Cys Asn Phe Met Asp Glu 
            740                 745                 750         


Arg Tyr Glu Asp Glu Tyr Gln Glu Ile Met Ser Pro Ile Lys Asn Glu 
        755                 760                 765             


Glu Glu Ala Lys Lys Trp Thr Glu Met Phe Thr Asp Lys Ala Asp Lys 
    770                 775                 780                 


Asp Asn Lys Asp Lys Leu Leu Val Leu Lys Thr Ser Phe Asp Lys Asp 
785                 790                 795                 800 


Asn Val Glu Lys Tyr Leu Leu Ala Leu Tyr Pro Leu Met Arg Leu Leu 
                805                 810                 815     


Asp Asp Lys Glu Leu Ser Glu Leu Gln Gln Gln Met Leu Arg Phe Arg 
            820                 825                 830         


Ala Ser Val Ser Gly Trp Gln Gly Gly Thr Asp Phe Ser Glu Asp Ile 
        835                 840                 845             


Ala Met Ala Glu Lys Ile Glu Glu Leu Ala Glu Leu Val Lys Leu Thr 
    850                 855                 860                 


Glu Pro Glu Ser Gln Tyr Ala Glu Glu Ala Trp Lys Asn Arg Ala Ile 
865                 870                 875                 880 


Gly Val Phe Glu Gln Phe Val Glu Gly Lys Met Ala Glu Tyr Gly Thr 
                885                 890                 895     


Phe Tyr Ile Gln Asn Asp Ser Leu Thr Gln Val Pro Arg Gly Asn Met 
            900                 905                 910         


Arg Lys Leu Leu Arg Ser Gly Val Ile Gly Val Tyr Asn Lys Val Leu 
        915                 920                 925             


Ala Ser Cys Lys Gln Ala Thr Lys Ala Asp Tyr Gly Ala Tyr Ser Gly 
    930                 935                 940                 


Asp His Trp Ser Ile Glu Asp Pro Asp Gly Asn Pro Ile Lys Ser Ala 
945                 950                 955                 960 


Glu Gln Ala Gln Ala Leu Leu Gln Arg Leu His Lys Lys Tyr Thr Glu 
                965                 970                 975     


Ser Pro Ser Gln Phe Ser Asp Asp Asp His Lys Leu Tyr Asp Lys Thr 
            980                 985                 990         


Leu Arg Gln Leu Asp Ala Tyr Asn  Arg Ala Met Lys Asn  Leu Ser Phe 
        995                 1000                 1005             


Gly Ser  Leu Tyr Glu Ile Cys  Arg Ile His Met Glu  Thr Leu Ser 
    1010                 1015                 1020             


Arg Trp  Val Gly Phe Val Gln  Asp Trp Glu Arg Asp  Met Tyr Phe 
    1025                 1030                 1035             


Leu Leu  Leu Ala Trp Thr Lys  Gln Gly Lys Leu Leu  Asn Val Thr 
    1040                 1045                 1050             


Glu Thr  Asp Val Ile Glu Ile  Phe Glu Lys Gly Ser  Val Ile Tyr 
    1055                 1060                 1065             


Lys Met  Asn Lys Lys Leu Lys  Asn Gly Asp Arg Tyr  Ala Phe Thr 
    1070                 1075                 1080             


Ser Ile  Tyr Arg Asn Asn Asn  Asp Glu Lys Leu Glu  Phe Leu Gln 
    1085                 1090                 1095             


Ile Arg  Asn Phe Ile Ala His  Leu His Leu Leu Arg  Lys Ser Glu 
    1100                 1105                 1110             


Trp Lys  Gly Asp Lys Lys Ala  Gly Tyr Ser Val Ile  Glu Asp Tyr 
    1115                 1120                 1125             


Ile Asn  Lys Leu Arg Phe Leu  Leu Ser Tyr Asp Gln  Lys Arg Met 
    1130                 1135                 1140             


Asn Ala  Val Thr Lys Ala Met  Gln Gln Ile Phe Glu  Lys His Lys 
    1145                 1150                 1155             


Val Ile  Val Lys Phe Met Val  Glu Lys Gly Gly Cys  Leu Arg Leu 
    1160                 1165                 1170             


Arg Met  
    1175 


<210>  769
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  769

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Pro Gly Thr Asp Thr 
            20                  25                  30          


Ile Asp Leu Lys Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Asp Lys Pro Lys Lys 
    50                  55                  60                  


Trp Lys Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Glu Tyr Val Lys Asn Ser Gln Glu Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Asp Ser Gln Gly Thr Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Gly Phe Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys His 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ser Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ser Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Phe 
            660                 665                 670         


Val Arg Lys Asn Phe Pro Glu Asp Ile Thr Asn Val Phe Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Lys Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Tyr 
                805                 810                 815     


Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Gly Trp Thr Ser Thr 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Leu Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Arg Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Gly  Asp Ile Glu Glu Phe  Tyr Asp Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Asp Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Met  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Glu Tyr Glu Lys Ile  Glu Ile Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Gly Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Val  Tyr Ala Pro Glu Lys  Gly Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Ile Gly  Val Lys Val 
    1145                 1150                 1155             


Asp Ala  Phe Lys Arg Tyr Ser  Glu His Leu Gly Leu  His Lys Glu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Ile  Ile Glu Glu 
    1175                 1180                 1185             


His Glu  Asp Val Ile Asn Leu  Arg Asn Ser Ile Asn  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Lys Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Met Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Tyr Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Phe Glu Ser  Gly Val Lys Thr Ile  Gly Asp Gln 
    1250                 1255                 1260             


Thr Lys  Pro Cys Ala Lys Leu  Ser Ile Lys Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Glu Tyr Lys Val Lys  Gly Gly Thr Leu Val  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Asp  Asp Glu Asp Ser Asn  Ala Lys Lys Pro Ala  Ile Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Gly Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Pro Asn 
    1370                 1375                 1380         


<210>  770
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  770

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  771
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  771

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Thr Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  772
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  772

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Ile Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Asp Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ile Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Arg Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Ile  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1400                 1405                 1410         


<210>  773
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  773

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Pro Gly Thr Asp Thr 
            20                  25                  30          


Ile Gly Leu Lys Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Asp Lys Pro Lys Lys 
    50                  55                  60                  


Trp Lys Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Glu Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Ser Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Met Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Tyr Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ser Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Gln Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Phe 
            660                 665                 670         


Ile Arg Lys Asn Phe Pro Glu Asp Ile Ser Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val Tyr Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Asp Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Asp Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asn  Ser Glu Lys Lys Glu  Ala Tyr Gln Lys Ile  Glu Val Asn 
    1100                 1105                 1110             


Gly Asp  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Val  Tyr Ala Pro Asp Glu  Lys Gly Asp 
    1130                 1135                 1140             


Ile Leu  Lys Glu Gln Cys Thr  Lys Gly Gly Ala Gly  Gly Lys Ile 
    1145                 1150                 1155             


Ser Ala  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Lys Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Lys Gln 
    1250                 1255                 1260             


Thr Thr  Ser Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Ser Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Lys  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Val Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Gly Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Pro Asn 
    1370                 1375                 1380         


<210>  774
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  774

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Lys Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn Gln Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Ile Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Asn Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Val Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Phe Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Gln Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Lys Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ala Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asp Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Ile Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Met Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Glu  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Ala Gln Gly  Gly Ala Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Arg Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Lys Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Met Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Cys Ile  Ser Ser Ile Lys Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Thr Leu Ile Thr Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Ser Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Gly Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  775
<211>  1287
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  775

Met Arg Ile Gly Lys Val Gln Gly Arg Thr Phe Thr Gly Phe Asp Asn 
1               5                   10                  15      


Ala Arg Gly Lys Thr Leu Arg Arg Arg Leu Leu Thr Arg Pro Asp Asn 
            20                  25                  30          


Glu Ala Arg Ser Leu Ser Glu His Leu Ala His Asp Pro Lys Ala Leu 
        35                  40                  45              


Ile Gly Gln Ala Ile Ser Arg Ile Asp Thr Ile Tyr Gln Lys Pro Lys 
    50                  55                  60                  


Thr Gly Lys Pro Thr Pro Glu Gln Phe Gly His Arg Asp Thr Leu Gly 
65                  70                  75                  80  


Trp Ala Tyr Trp Lys Leu Leu Val Ala Ser Tyr Pro Glu Val Glu Gly 
                85                  90                  95      


His Arg Asp Leu Phe Val Arg Arg Leu His Pro Tyr Gly Asp Thr Pro 
            100                 105                 110         


Pro Lys Ser His Gly Gln Lys Glu Gly Glu His Gln Lys Gly Gly Lys 
        115                 120                 125             


Pro Gln Leu Glu Gly Arg Trp His Gly Val Met Ala Gln His Gly Lys 
    130                 135                 140                 


Asn Pro Asp Gln Ile Ala Ala Arg Leu Phe Asp His Leu His Asn Ser 
145                 150                 155                 160 


Glu Leu Arg Phe Gly Gly Thr Ala Ser Gly Glu Pro Arg Thr Arg Pro 
                165                 170                 175     


Gly Lys Glu Ala Thr Pro Thr Gly Leu Ile Gly Ala Arg Ala Lys Thr 
            180                 185                 190         


Ile Glu His Ser Val Leu Pro Arg Asp Ala Lys Arg Phe Val Ala Glu 
        195                 200                 205             


Trp Arg Gly Glu Asp Gln Glu Arg Tyr Ala Gly Ala Arg Asp Ile Ala 
    210                 215                 220                 


Ala Ala Ile Ser Ala Gly Leu Asn Asp Lys Asp Gln Lys Ser Gly Ser 
225                 230                 235                 240 


Gly Arg Lys Ser Ala Val Ile Gly Lys Leu Leu Ser Asp His Leu Glu 
                245                 250                 255     


Thr Leu Thr Gly Asn Arg Lys Cys Arg Phe Asp Pro Lys Ser Thr Ala 
            260                 265                 270         


Glu Thr Leu Glu Leu Arg Asp Gly Glu Ser Val Asp Asp Arg Arg Arg 
        275                 280                 285             


Ile Leu Glu Leu His Ala Glu Val Lys Ala Thr Tyr Lys Arg Met Ala 
    290                 295                 300                 


Ala Trp Lys Pro Ala Lys Leu Pro Arg Asn Ser Asp Glu Leu Phe Arg 
305                 310                 315                 320 


Leu Val Arg Gln Gln Ala Asp Asn Arg Ile Leu Asn His Leu Val Arg 
                325                 330                 335     


Val Gly Arg Ile Ser Val Tyr Ser Glu Gln Ser Asp Ala Leu Ser Glu 
            340                 345                 350         


Ser Gln Phe Trp Thr Ser Gly Gly Gln Thr Gln Ile Lys Glu Ser Glu 
        355                 360                 365             


Val Phe Ala Arg Leu Trp Ile Gly Ala Ile Ser Arg Ala Ser Tyr Ser 
    370                 375                 380                 


Met Lys Ala Trp Leu Glu Pro Glu Gly Thr Val Phe Asn Pro Ser Ile 
385                 390                 395                 400 


Asn Asp Phe Asp Val Thr Ser Ser His Asn Thr Asn Arg Ile Leu Glu 
                405                 410                 415     


Asp Ser Gly Arg Leu Ser Asn Ala Met Ala Arg Arg Ala Ile Tyr Phe 
            420                 425                 430         


Gly Glu Thr Pro Glu Phe Asp Ala Leu Gly Glu Glu Asp Gln Arg Val 
        435                 440                 445             


Leu Val Lys Lys Cys Leu Asp Ala Leu Ser Ala Cys Arg Asn Arg Thr 
    450                 455                 460                 


Phe His His Gly Gln Arg Ala Lys Phe Leu Lys Glu Val Arg Lys Gly 
465                 470                 475                 480 


Leu Lys Glu Lys Glu Ala Asp Ser Ala Gly Pro Ala Ala Trp Glu Gly 
                485                 490                 495     


Ile Arg Glu Val Ile Gln Ala Asp Ala Arg Asn Leu Gly Ala Arg Leu 
            500                 505                 510         


Leu Gln Asp Leu Thr Gly Ala Lys Val His Ser Phe Ala Thr Asp Pro 
        515                 520                 525             


Glu Phe Arg His Leu Tyr Glu Ser Val Ala Ala Thr Leu Thr Ala Gly 
    530                 535                 540                 


Gly Glu Leu Glu Ala Ala Leu Pro Arg Leu Lys Asn Val Leu Lys Arg 
545                 550                 555                 560 


Ala Glu Gly Val Arg Cys Tyr Leu Asp Thr Pro Ser Gln Arg Arg Glu 
                565                 570                 575     


Gly Asp Glu Ser Leu Ile Ala Arg Leu Pro Val Ala Pro Val Pro Arg 
            580                 585                 590         


Glu Leu Asp Asp Ala Ala Thr Lys Ala Arg His Ser Ala Leu Leu Arg 
        595                 600                 605             


Leu Tyr Asp Gly Pro Phe Arg Pro Trp Ala Thr Glu Leu Arg Gly Glu 
    610                 615                 620                 


Arg Leu Ser Asp Tyr Ala Ala Arg Ala Lys Arg Leu Ala Thr Arg Leu 
625                 630                 635                 640 


Ala Lys Ser Thr Asn Thr Ala Ser Pro Tyr Pro Asp Ser Val Glu Gly 
                645                 650                 655     


Arg Ser Val Arg Leu Arg Asp Pro Ile Thr Ala Asp Thr Ala Pro Glu 
            660                 665                 670         


Thr Leu Lys Thr Tyr Leu Ser Ala Leu Thr Ala Glu Thr Ala Thr Glu 
        675                 680                 685             


Phe Arg Val Gln Lys Gly Tyr Glu Ser Asp Gly Glu Lys Ala Lys Glu 
    690                 695                 700                 


Gln Ala Glu Phe Ile Glu Asp Phe Arg Arg Asp Met Ile Ala Leu Ala 
705                 710                 715                 720 


Phe Gln Asp Phe Ile Arg Asp His Gly Phe Ala Trp Leu Leu Asp Ile 
                725                 730                 735     


Ala Ser Lys Ala Glu Pro Ser Asn Asp Ala Pro Asn Leu Pro Asp Pro 
            740                 745                 750         


Val Asp Thr Gly Lys Asp Thr Val Phe Glu Asp Trp Gln Ala Leu Leu 
        755                 760                 765             


Tyr Leu Phe Leu His Phe Val Pro Ala Asp Asp Val Ser Gln Leu Leu 
    770                 775                 780                 


His Gln Leu Arg Lys Trp Asp Ala Leu Gln Asp Lys Tyr Glu Leu Ala 
785                 790                 795                 800 


Glu Pro Gly Glu Thr Leu Gly Gln Thr Lys Ala Asp Thr Arg Lys Ile 
                805                 810                 815     


Val Gly Gln Phe Arg Asp Cys Leu Thr Leu Phe Leu Lys Thr Gly Asp 
            820                 825                 830         


Ala Arg Phe Asp Gly Glu Gly Val Glu Leu Pro Leu Ser Asp Phe Gln 
        835                 840                 845             


Glu Leu Phe Glu Ser Pro Ala Thr Phe Lys Glu Leu Phe Leu Ala Glu 
    850                 855                 860                 


Pro Ala Glu Asn Asp Ala Ser Glu Thr Asp Asp Gln Asp Ala Pro Gly 
865                 870                 875                 880 


Glu Lys His Arg Val Thr Arg Thr Arg Arg Gly Leu Arg Gln Ile Leu 
                885                 890                 895     


Arg Tyr Asn His Met Pro Val Leu Arg Asp Leu Phe Leu Ala His Lys 
            900                 905                 910         


Val Thr Asp Ala Glu Val Asp Gly Leu Gln Ala Leu Glu Val Asp Asp 
        915                 920                 925             


Pro Gln Thr Gly Glu Ser Gln Ile Gly Ala Ala Gln Arg Ile Arg Thr 
    930                 935                 940                 


Glu Ile His His His Thr Ser Asn Asp Lys Gln Ile Ser Glu Ala Lys 
945                 950                 955                 960 


Val Glu Glu Tyr Arg Arg Ala Leu Ser Thr Ile Glu Arg His Arg Phe 
                965                 970                 975     


Leu Val Gly Arg Val Tyr Leu Gly Asp His Ile Arg Val His Lys Leu 
            980                 985                 990         


Met Met Asp Val Met Gly Arg Leu  Val Asp Phe Ala Gly  Ala Trp Glu 
        995                 1000                 1005             


Arg Glu  Ala Ala Asp Gly Asp  Arg Lys Gly Phe Ile  Ser Arg Ala 
    1010                 1015                 1020             


Ile Ala  Leu Pro Glu Val Ala  Glu Gly Tyr Ala Ala  Asp Arg Leu 
    1025                 1030                 1035             


Lys Thr  Val Ala Arg Arg Val  Leu Asp Asp Gly Glu  Ala Arg Arg 
    1040                 1045                 1050             


Ile Arg  Asn Asp Leu Gly His  Phe Asn Asp Leu Ala  Pro Thr Ser 
    1055                 1060                 1065             


Gly Pro  Ala Asn Leu Thr Phe  Val Val Asn Arg Ala  Arg Arg Met 
    1070                 1075                 1080             


Met Arg  His Asp Arg Lys Arg  Lys Asn Ala Val Thr  Lys Ser Val 
    1085                 1090                 1095             


Ile Glu  Ile Leu Asn Arg Gln  Gly Leu Gly Ile Glu  Trp Thr Met 
    1100                 1105                 1110             


Arg Asn  His Glu Leu Cys Glu  Ala Lys Leu Trp Gln  Asn Pro Val 
    1115                 1120                 1125             


Lys His  Leu Gly Phe Ala Thr  Leu Glu Gly Arg Gly  Lys Lys Trp 
    1130                 1135                 1140             


Arg Arg  Pro Phe Glu Ala Arg  Tyr Gly Asp Ala Tyr  Met Ala Met 
    1145                 1150                 1155             


Val Ala  Gln Leu Phe Asp Gly  Thr Val Thr Ser Pro  Pro Ala Lys 
    1160                 1165                 1170             


Gly Pro  Pro Gln Ser Gly Lys  Ser Gly Gly Lys Pro  Gly Lys Gly 
    1175                 1180                 1185             


Ala Glu  Gly Gly Ala Lys Glu  Lys Ser Arg Ser Pro  Thr Arg Met 
    1190                 1195                 1200             


Glu Glu  Gly Gly Val Tyr Glu  Gly Arg Val Ala Lys  Ala Lys Ser 
    1205                 1210                 1215             


Asp Lys  Gly Phe Gly Phe Leu  Leu Val Glu Gly Ala  Gln Glu Glu 
    1220                 1225                 1230             


Ile Phe  Leu His Ile Tyr Gly  Ile Ser Gly Asn Arg  Pro Ala Arg 
    1235                 1240                 1245             


Ile Glu  Asn Gly Gln Arg Tyr  Arg Phe Thr Leu Gly  Ile Asp Arg 
    1250                 1255                 1260             


Asp Arg  Glu Arg Arg Lys Glu  Arg Ala Trp Val Ala  Arg Glu Ala 
    1265                 1270                 1275             


Val Arg  Ile Asp Glu Asn Arg  Ser Lys 
    1280                 1285         


<210>  776
<211>  1101
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  776

Met Arg Ile Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Ile Tyr Ser Glu 
            20                  25                  30          


Gln Ala Val Ser Asn Glu Thr Asn Asn Ile Leu Pro Val Lys Lys Met 
        35                  40                  45              


Asp Ser Phe Asn Leu Ser Ile Leu Asn Lys Thr Ile Ile Lys Phe Glu 
    50                  55                  60                  


Thr Val Lys Lys Gln Lys Leu Asn Leu Asp Gln Tyr Lys Ile Val Glu 
65                  70                  75                  80  


Lys Ile Phe Lys Tyr Pro Lys Gln Glu Leu Pro Lys Gln Ile Asn Ala 
                85                  90                  95      


Glu Glu Ile Leu Gln Phe Leu Asn His Lys Phe Gln Glu Pro Val Lys 
            100                 105                 110         


Tyr Trp Lys Asn Gly Lys Glu Glu Ser Phe Asn Leu Thr Leu Leu Ile 
        115                 120                 125             


Val Glu Ala Val Lys Thr Gln Glu Lys Arg Lys Leu Gln Pro Tyr Tyr 
    130                 135                 140                 


Asp Trp Lys Thr Trp Tyr Ile Gln Thr Lys Ser Asp Leu Leu Lys Lys 
145                 150                 155                 160 


Ser Ile Glu Asn Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg 
                165                 170                 175     


Lys Lys Ala Leu Leu Ala Trp Glu Thr Glu Phe Thr Thr Ser Gly Ser 
            180                 185                 190         


Ile Asp Leu Thr His Phe His Lys Val Tyr Met Thr Asp Val Leu Cys 
        195                 200                 205             


Thr Ala Leu Gln Lys Val Glu Pro Ser Ala Asp Glu Arg Gly Lys Met 
    210                 215                 220                 


Asn Ser Asn Ala Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Asn His 
225                 230                 235                 240 


Gln Pro Ala Ile Phe Gly Thr Arg Glu Ala Pro Asn Glu Val Asn Arg 
                245                 250                 255     


Ala Asp Asn Gln Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu 
            260                 265                 270         


Glu His Tyr Phe Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Ala Asp 
        275                 280                 285             


Asp Ile Ser His Tyr Leu Lys Ala Gln Thr Leu Lys Thr Thr Ile Glu 
    290                 295                 300                 


Lys Gln Leu Val Asn Ala Ile Arg Ala Asn Ile Ile Gln Gln Gly Lys 
305                 310                 315                 320 


Thr Asn His His Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile 
                325                 330                 335     


Arg Ile Lys Thr Asn Glu Ala Phe Val Leu Asn Leu Ile Gly Thr Cys 
            340                 345                 350         


Ala Phe Ala Ala Asn Asn Ile Arg Asn Met Val Asp Lys Glu Gln Ile 
        355                 360                 365             


Ser Asp Ile Leu Gly Lys Arg Glu Phe Ile Asp Ser Leu Thr Lys Ser 
    370                 375                 380                 


Arg Ile Ser Ser Gln Leu Tyr Ser Phe Phe Phe Gly Glu Asn Leu Ser 
385                 390                 395                 400 


Thr Asn Lys Ala Glu Lys Glu Thr Gln Leu Trp Gly Ile Arg Gly Ala 
                405                 410                 415     


Val Gln Gln Ile Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu 
            420                 425                 430         


Thr Thr Ile Phe Asn Ile Cys Lys Phe Glu Asn Pro Thr Asp Ala Asp 
        435                 440                 445             


Pro Lys Gln Gln Thr Asn Tyr Val Asp Ser Ile Tyr Lys Thr Leu Phe 
    450                 455                 460                 


Ile Lys Glu Leu Glu Lys Ile Pro Glu Ala Phe Ala Gln Gln Leu Lys 
465                 470                 475                 480 


Thr Gly Gly Ala Leu Ser Tyr Tyr Thr Val Glu Asn Leu Lys Thr Leu 
                485                 490                 495     


Leu Thr Thr Phe Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala 
            500                 505                 510         


Pro Gly Phe Lys Lys Val Leu Asn Gly Gly Ile Asn Tyr Gln Asn Ala 
        515                 520                 525             


Lys Gln Asp Glu Ser Phe Tyr Glu Leu Met Leu Glu Arg Tyr Leu Arg 
    530                 535                 540                 


Lys Glu Asn Phe Ala Glu Glu Ala Tyr Asn Ala Arg Tyr Phe Leu Leu 
545                 550                 555                 560 


Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Lys Phe Thr Ala Asp Arg 
                565                 570                 575     


Lys Ala Phe Ala Asp Ser Val Gly Phe Val Gln Leu Gln Asn Arg Lys 
            580                 585                 590         


Gln Ala Glu Asn Ser Lys Arg Pro Lys Ala Phe Ala Phe Glu Ala Val 
        595                 600                 605             


Arg Pro Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala Tyr Val 
    610                 615                 620                 


Gln Ser Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys Ala Thr 
625                 630                 635                 640 


Asp Glu Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val Phe Ile 
                645                 650                 655     


Lys Gly Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe Val Gln 
            660                 665                 670         


Val Pro Gln Pro Gln Leu Thr Thr Thr Asp Ser Asn Gln Gln Lys Ala 
        675                 680                 685             


Asp Lys Leu Asn Gln Leu Glu Ala Ser Ile Thr Ala Asp Cys Lys Leu 
    690                 695                 700                 


Thr Ala Gln Tyr Ala Lys Thr Asp Asp Ala Thr His Ile Ala Phe Tyr 
705                 710                 715                 720 


Val Phe Cys Lys Leu Leu Asp Ala Gly His Leu Ser Asn Leu Arg Asn 
                725                 730                 735     


Glu Leu Ile Lys Phe Arg Gly Ser Val Lys Asp Phe Asp Phe His His 
            740                 745                 750         


Leu Leu Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val Val Pro 
        755                 760                 765             


Thr Asp Tyr Arg Asp Leu Tyr Ser Ser Gly Ala Asp Cys Leu Ala Arg 
    770                 775                 780                 


Leu Arg Pro Phe Ile Glu Gln Gly Ala Asp Ile Lys Asn Trp Ser Asp 
785                 790                 795                 800 


Leu Tyr Val Gln Thr Asp Lys Gln Thr Pro Val Ile His Ala Gly Ile 
                805                 810                 815     


Glu Leu Ser Val Lys Tyr Gly Thr Thr Ala Leu Leu Glu Gln Leu Ile 
            820                 825                 830         


Thr Cys Asn Pro Lys Phe Arg Val Met Glu Asp Asn Phe Thr Lys Trp 
        835                 840                 845             


Ser Ala Gln Lys Lys Glu Ile Glu Glu Lys Val Asn Lys His Thr Asn 
    850                 855                 860                 


Leu His Gln Gln Trp Val Glu Ala Lys Glu Lys Asp Asp Arg Glu Arg 
865                 870                 875                 880 


Val Lys Ser Lys Lys Asn Phe Val Arg Glu Tyr Val Lys Lys Asn Tyr 
                885                 890                 895     


Val Asp Tyr Ile Asn Asn Cys Ile Glu Ile Asn Asn Tyr Asn Trp Leu 
            900                 905                 910         


Asp Asn Lys Leu His Phe Val His Leu Asn His Leu His His Leu Thr 
        915                 920                 925             


Ile Asp Ile Leu Gly Arg Met Ala Gly Phe Val Ala Leu Trp Glu Arg 
    930                 935                 940                 


Asp Phe Gln Tyr Ile Thr Lys Tyr Thr Ala Ala Lys Glu Gly Thr Asp 
945                 950                 955                 960 


Ala Leu Ser Phe Asp Gly Gly Leu Pro Arg Leu Lys Asp Lys Gln Glu 
                965                 970                 975     


Tyr Tyr Asn Lys Leu Phe Leu Ser Asp Lys Tyr Thr Lys Val Arg Asn 
            980                 985                 990         


His Ile Ala His Phe Asn Tyr Leu  Thr Lys Asp Ala Ala  Asp Phe Ala 
        995                 1000                 1005             


Leu Leu  Asp Leu Ile Asn Glu  Leu Arg Glu Leu Leu  His Tyr Gly 
    1010                 1015                 1020             


Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ala Phe Ile  Asp Leu Phe 
    1025                 1030                 1035             


Glu Lys  His Gly Met Ile Leu  Lys Leu Lys Leu Asn  Thr Asp His 
    1040                 1045                 1050             


Gln Leu  Val Val Glu Ser Ile  Glu Pro Lys Lys Ile  Tyr His Leu 
    1055                 1060                 1065             


Gly Ser  Thr Ala Lys Asp Lys  Pro Glu Tyr Gln Tyr  Thr Thr Asn 
    1070                 1075                 1080             


Gln Val  Met Thr Val Tyr Cys  Asn Met Cys Arg Ser  Leu Leu Glu 
    1085                 1090                 1095             


Met Lys  Lys 
    1100     


<210>  777
<211>  1396
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  777

Met Gly Asn Leu Phe Gly His Lys Lys Trp Tyr Lys Ala Asp Lys Ile 
1               5                   10                  15      


Ile Lys Asp Lys Lys Gly Lys Glu Ser Thr Ile Lys Gln Glu Val Arg 
            20                  25                  30          


Ile Lys Arg Asn Tyr Ser Val Asp Arg Tyr Thr Leu Asn Thr Asn Asn 
        35                  40                  45              


Lys Val Lys Asn Asn Ile Asn Asn Glu Asp Phe Val Asn Gln Phe Ile 
    50                  55                  60                  


Glu Tyr Lys Thr Asn Asn Asp Ile Phe Lys Lys Phe Thr Lys Lys Phe 
65                  70                  75                  80  


His Met Gly Asn Ile Leu Phe Lys Leu Lys Ala Glu Glu Ser Val Lys 
                85                  90                  95      


Glu Ile Arg Asn Tyr Asn Asp Phe Leu Glu Lys Glu Lys Ala Ile Leu 
            100                 105                 110         


Glu Ile Glu Ile Tyr Gln Gln Ser Glu Glu Leu Arg Lys Lys Glu Asn 
        115                 120                 125             


Ile Thr Lys Lys Asp Ile Ile Asn Lys Val Ile Asn Asp Gly Ile Thr 
    130                 135                 140                 


Glu Asp Ser Asn Glu Ile Asn Met Lys Ile Lys Thr Lys Lys Asn Asn 
145                 150                 155                 160 


Phe Glu Glu Ile Arg Ile Ile Ile Asn Asn Glu Ser Glu Glu Tyr Tyr 
                165                 170                 175     


Ile Lys Leu Arg Ser Leu Asn Asn Asn Glu Leu Asn Leu Lys Arg Glu 
            180                 185                 190         


Ile Tyr Glu Val Leu Lys Ser Ile Asn Ala Asn Leu Tyr Thr Phe Thr 
        195                 200                 205             


Lys Asn Ala Ile Asp Asp Thr Asp Phe Lys Lys Arg Asn Tyr Glu Asn 
    210                 215                 220                 


Phe Leu Arg Glu Asn Met Met Lys His Leu Lys Lys Asn Ile Lys Glu 
225                 230                 235                 240 


Lys Tyr Glu Ile Thr Phe Phe Lys Ser Leu Ser Asn Ser Leu Lys Lys 
                245                 250                 255     


Ile Gln Gly Asn Ile Lys Lys Asn Asp Glu Ile Ile Asn Phe Ile Lys 
            260                 265                 270         


Tyr Tyr Ser Asn Ile Asn Gly Ser Lys Thr Val Ser Glu Asn Lys Lys 
        275                 280                 285             


Lys Phe Leu Glu Lys Ile Leu Asn Thr Glu Val Ser Ile Ser Glu Asn 
    290                 295                 300                 


Asp Ile Ile Asp Phe Ile Ile Gly Glu Leu Lys Phe Phe Gly Ile Ile 
305                 310                 315                 320 


Lys Arg Ile Glu Lys Leu Gln Glu Lys Thr Val Asn Arg Thr Asp Gly 
                325                 330                 335     


Asp Ile Lys Asn Thr Tyr Val Asn Thr Tyr Val Leu Leu Asp Lys His 
            340                 345                 350         


Glu Lys Phe Lys Lys Tyr Asn Arg Asn Lys Lys Asp Thr Ile Ile Lys 
        355                 360                 365             


Ser Phe Ile Lys Asn Ile Lys Asp Asn Thr Met Lys Gln Lys Ile Asn 
    370                 375                 380                 


Gln Ile Leu Arg Lys Phe Lys Ile Glu Glu Leu Ile Glu Lys Leu Arg 
385                 390                 395                 400 


Ile Lys Asn Lys Asn Phe Asp Thr Glu Ile Phe Lys Ile Phe Lys Asp 
                405                 410                 415     


His Tyr Gln Glu Met Phe Ser Ser Glu Lys Phe Glu Glu Lys Ser Asp 
            420                 425                 430         


Glu Glu Lys Glu Leu Tyr Lys Ile Ile Tyr Arg Tyr Leu Lys Glu Arg 
        435                 440                 445             


Ile Glu Lys Ile Leu Ile Asn Glu Gln Lys Val Arg Leu Lys Lys Met 
    450                 455                 460                 


Glu Lys Ile Glu Ile Glu Lys Ile Leu Asn Glu Ser Ile Leu Ser Glu 
465                 470                 475                 480 


Lys Val Leu Lys Arg Val Lys Gln Tyr Thr Leu Glu Tyr Val Met Tyr 
                485                 490                 495     


Leu Gly Lys Leu Ile His Asn Asp Val Asn Met Thr Thr Val Asn Thr 
            500                 505                 510         


Asp Asp Phe Thr Lys Leu His Ala Lys Glu Glu Leu Asp Leu Glu Leu 
        515                 520                 525             


Ile Thr Phe Phe Ala Ser Thr Asn Met Glu Leu Asn Lys Ile Phe Asn 
    530                 535                 540                 


Gly Lys Glu Lys Ile Thr Asp Phe Phe Gly Phe Asn Leu Asn Gly Gln 
545                 550                 555                 560 


Lys Ile Thr Leu Lys Glu Lys Val Pro Asp Phe Lys Leu Asn Ile Leu 
                565                 570                 575     


Lys Lys Leu Asn Phe Ile Asn Asn Glu Asn Asn Ile Asp Glu Lys Leu 
            580                 585                 590         


Ser His Phe Tyr Ser Phe Gln Lys Glu Gly Tyr Leu Leu Arg Asn Arg 
        595                 600                 605             


Ile Leu His Asn Ser Tyr Gly Asn Ile Gln Glu Thr Lys Asn Leu Glu 
    610                 615                 620                 


Gly Glu Tyr Glu Asn Val Glu Asn Leu Ile Lys Glu Leu Lys Val Ser 
625                 630                 635                 640 


Asp Glu Glu Ile Ser Lys Ser Leu Asn Leu Asp Ile Ile Phe Glu Gly 
                645                 650                 655     


Lys Val Asp Ile Ile Asn Lys Ile Asn Ser Leu Glu Ile Gly Glu Tyr 
            660                 665                 670         


Lys Asp Lys Lys Tyr Leu Pro Ser Phe Ser Lys Ile Ile Pro Glu Ile 
        675                 680                 685             


Ile Arg Lys Phe Arg Glu Ile Asn Lys Asp Lys Leu Phe Asp Glu Glu 
    690                 695                 700                 


Ser Glu Lys Ile Ile Leu Asn Val Val Lys Tyr Val Asn Lys Ile Leu 
705                 710                 715                 720 


Tyr Glu Lys Ile Thr Ser Asn Glu Glu Asn Lys Phe Ile Lys Thr Leu 
                725                 730                 735     


Pro Asp Lys Leu Val Lys Lys Asn Asn Ile Lys Lys Glu Asn Lys Asn 
            740                 745                 750         


Leu Leu Ser Ile Glu Glu Tyr Tyr Lys Asn Ala Gln Val Ser Ser Ser 
        755                 760                 765             


Lys Gly Asp Lys Lys Ala Ile Lys Lys Tyr Gln Asn Lys Val Ile Asn 
    770                 775                 780                 


Ala Tyr Leu Glu Tyr Leu Glu Asn Thr Phe Glu Lys Val Ile Asp Phe 
785                 790                 795                 800 


Ser Asn Phe Asn Leu Asn Tyr Asn Glu Ile Lys Thr Lys Ile Glu Glu 
                805                 810                 815     


Arg Lys Asn Ser Lys Asn Lys Ile Val Ile Lys Ser Ile Pro Ile Asn 
            820                 825                 830         


Ile Asn Ile Thr Asn Asp Thr Glu Tyr Ile Ile Ser Ile Phe Ala Leu 
        835                 840                 845             


Leu Asn Asn Asn Thr Tyr Leu Asn Lys Ile Arg Asn Arg Phe Phe Ala 
    850                 855                 860                 


Thr Ser Val Trp Leu Asn Thr Gln Glu Tyr Glu Asn Leu Ile Asp Ile 
865                 870                 875                 880 


Leu Asp Lys Val Leu Ser Ile Asn Leu Leu Arg Glu Asn Asn Ile Ile 
                885                 890                 895     


Asp Ile Leu Asp Leu Lys Asn Thr Ile Ile Glu Ala Lys Ile Thr Glu 
            900                 905                 910         


Asn Asn Glu Glu Tyr Ile Arg Asn Tyr Ile Phe Glu Asn Asn Lys Glu 
        915                 920                 925             


Glu Leu Lys Lys Arg Leu Phe Cys Glu Glu Leu Asp Asn Lys Glu Asp 
    930                 935                 940                 


Val Leu Lys Ile Phe Glu Asp Lys Asn Phe Lys Phe Lys Asn Phe Ile 
945                 950                 955                 960 


Lys Lys Asn Glu Ser Gly Asn Phe Lys Ile Asn Phe Ala Ile Leu Ser 
                965                 970                 975     


Asn Leu Glu Cys His Phe Glu Leu Asp Thr Lys Lys Val Ile Gly Lys 
            980                 985                 990         


Asn Ser Lys Lys Leu Glu Ser Phe  Ile Gln Asn Thr Ile  Asp Glu Tyr 
        995                 1000                 1005             


Lys Ser  Asn Ile Arg Thr Leu  Phe Ser Ser Glu Phe  Leu Glu Lys 
    1010                 1015                 1020             


Tyr Lys  Lys Glu Ile Asp Asn  Leu Met Gly Asp Ile  Glu Ser Glu 
    1025                 1030                 1035             


Asn Glu  Ser Lys Phe Glu Lys  Ile Tyr Tyr Pro Glu  Glu His Lys 
    1040                 1045                 1050             


Asn Glu  Leu Tyr Ile Tyr Lys  Lys Asn Leu Phe Leu  Asn Ile Gly 
    1055                 1060                 1065             


Asn Pro  Asn Phe Asp Lys Ile  Tyr Gly Leu Ile Ser  Lys Asp Ile 
    1070                 1075                 1080             


Lys Asn  Val Asp Thr Lys Ile  Leu Phe Asp Asp Asp  Ile Arg Lys 
    1085                 1090                 1095             


Asn Lys  Ile Ser Glu Ile Asp  Ala Ile Leu Lys Asn  Leu Asn Asp 
    1100                 1105                 1110             


Lys Leu  Asn Gly Tyr Ser Asn  Asp Tyr Lys Ala Lys  Tyr Val Asn 
    1115                 1120                 1125             


Lys Leu  Lys Glu Asn Asp Asp  Phe Phe Ala Lys Asn  Ile Gln Asn 
    1130                 1135                 1140             


Glu Asn  Tyr Ser Ser Phe Gly  Glu Phe Glu Lys Asp  Tyr Asn Lys 
    1145                 1150                 1155             


Val Ser  Glu Tyr Lys Lys Ile  Arg Asp Leu Val Glu  Phe Asn Tyr 
    1160                 1165                 1170             


Leu Asn  Lys Ile Glu Ser Tyr  Leu Ile Asp Ile Asn  Trp Lys Leu 
    1175                 1180                 1185             


Ala Ile  Gln Met Ala Arg Phe  Glu Arg Asp Met His  Tyr Ile Val 
    1190                 1195                 1200             


Asn Gly  Leu Arg Glu Leu Gly  Ile Ile Lys Leu Ser  Gly Tyr Asn 
    1205                 1210                 1215             


Thr Gly  Ile Ser Arg Ala Tyr  Pro Lys Arg Asn Gly  Ser Asp Asp 
    1220                 1225                 1230             


Phe Tyr  Ala Thr Thr Ala His  Tyr Lys Phe Phe Asp  Glu Glu Ser 
    1235                 1240                 1245             


Tyr Lys  Lys Phe Glu Lys Ile  Cys Tyr Gly Phe Arg  Ile Asp Leu 
    1250                 1255                 1260             


Ser Glu  Asn Ser Glu Ile Asn  Lys Pro Glu Asn Glu  Ser Ile Arg 
    1265                 1270                 1275             


Asn Tyr  Ile Ser His Phe Tyr  Ile Val Arg Asn Pro  Phe Val Asp 
    1280                 1285                 1290             


Tyr Ser  Ile Ala Gln Gln Ile  Asp Arg Val Ser Asn  Leu Leu Ser 
    1295                 1300                 1305             


Tyr Ser  Thr Arg Tyr Asn Asn  Ser Thr Tyr Ala Gly  Val Phe Glu 
    1310                 1315                 1320             


Val Phe  Lys Lys Asp Val Asn  Leu Asp Tyr Asp Lys  Leu Lys Thr 
    1325                 1330                 1335             


Lys Phe  Lys Leu Phe Asp Asp  Glu Lys Asn Asp Asn  Ile Lys Ile 
    1340                 1345                 1350             


Leu Lys  Ile Lys Asn Leu Ile  Glu Ser Lys Lys Val  Ser Val Leu 
    1355                 1360                 1365             


Glu Leu  Glu Ser Tyr Asn Ser  Asp Tyr Val Lys Asn  Leu Ile Ile 
    1370                 1375                 1380             


Glu Leu  Leu Thr Lys Ile Glu  Asn Thr Asn Asp Thr  Leu 
    1385                 1390                 1395     


<210>  778
<211>  1159
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  778

Met Lys Val Thr Lys Val Gly Gly Ile Ser His Lys Lys Tyr Thr Ser 
1               5                   10                  15      


Glu Gly Arg Leu Val Lys Ser Glu Ser Glu Glu Asn Arg Thr Asp Glu 
            20                  25                  30          


Arg Leu Ser Ala Leu Leu Asn Met Arg Leu Asp Met Tyr Ile Lys Asn 
        35                  40                  45              


Pro Ser Asn Thr Glu Thr Lys Glu Asn Lys Lys Arg Ile Gly Lys Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Met Val Tyr Leu Lys Asp Asn Thr Leu 
65                  70                  75                  80  


Ser Leu Lys Asn Gly Lys Lys Glu Asn Ile Asp Arg Glu Tyr Ser Glu 
                85                  90                  95      


Thr Asp Ile Ser Glu Tyr Asp Val Arg Asp Ser Lys Asn Phe Ala Val 
            100                 105                 110         


Leu Lys Lys Ile Tyr Leu Asn Glu Asn Val Asn Ser Glu Glu Leu Glu 
        115                 120                 125             


Val Phe Arg Lys Asp Ile Lys Lys Lys Leu Asn Lys Ile Asn Ser Leu 
    130                 135                 140                 


Lys Tyr Ser Phe Glu Lys Asn Lys Ala Asn Tyr Gln Lys Ile Asn Glu 
145                 150                 155                 160 


Asn Asn Ile Glu Lys Val Glu Gly Lys Ser Lys Arg Asn Ile Ile Tyr 
                165                 170                 175     


Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asp Ala Tyr Val Ser Asn Val 
            180                 185                 190         


Lys Glu Ala Phe Asp Lys Leu Tyr Lys Glu Glu Asp Ile Ala Lys Leu 
        195                 200                 205             


Val Leu Lys Ile Glu Asn Leu Thr Lys Leu Glu Lys Ser Lys Ile Arg 
    210                 215                 220                 


Glu Phe Tyr His Glu Ile Ile Gly Arg Lys Asn Asp Lys Glu Asn Phe 
225                 230                 235                 240 


Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Met Lys Glu 
                245                 250                 255     


Leu Ile Glu Lys Val Pro Asn Met Ser Glu Leu Lys Lys Ser Gln Val 
            260                 265                 270         


Phe Tyr Lys Tyr Tyr Leu Asn Lys Glu Glu Leu Asn Asp Lys Asn Ile 
        275                 280                 285             


Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln Leu Leu 
    290                 295                 300                 


Lys Asn Tyr Val Tyr Lys Gly Leu Ser Asn Ile Ser Asn Asp Lys Ile 
305                 310                 315                 320 


Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu Asn Lys 
                325                 330                 335     


Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys Tyr Asn 
            340                 345                 350         


Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile Ala Arg 
        355                 360                 365             


Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val Ser Ser 
    370                 375                 380                 


Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn Glu Asn 
385                 390                 395                 400 


Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn Lys Gly 
                405                 410                 415     


Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn Glu Asn 
            420                 425                 430         


Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser Tyr Asp 
        435                 440                 445             


Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala Asn Ile 
    450                 455                 460                 


Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe Asn Leu 
465                 470                 475                 480 


Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala Pro Ser 
                485                 490                 495     


Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys Lys Leu 
            500                 505                 510         


Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe Arg Tyr 
        515                 520                 525             


Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg Phe Glu 
    530                 535                 540                 


Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys Leu Tyr 
545                 550                 555                 560 


Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp Lys Thr 
                565                 570                 575     


Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp Ala Gln 
            580                 585                 590         


Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn Tyr Phe 
        595                 600                 605             


Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Lys Glu Ile Ile Glu 
    610                 615                 620                 


Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr Lys Leu 
625                 630                 635                 640 


Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr Leu Ala 
                645                 650                 655     


Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp Glu Glu 
            660                 665                 670         


Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu Lys Gly 
        675                 680                 685             


Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile Tyr Ile 
    690                 695                 700                 


Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys Gln Glu 
705                 710                 715                 720 


Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile Glu Ile 
                725                 730                 735     


Pro His Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly Asn Ile 
            740                 745                 750         


Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu Lys Leu 
        755                 760                 765             


Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu Lys Tyr 
    770                 775                 780                 


Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu Leu Ile 
785                 790                 795                 800 


Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe Glu Leu 
                805                 810                 815     


Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn Lys Ile 
            820                 825                 830         


Lys Asp Lys Lys Glu Leu Lys Lys Phe Asp Thr Lys Lys Ile Tyr Phe 
        835                 840                 845             


Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile Lys Lys 
    850                 855                 860                 


Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala Lys Tyr 
865                 870                 875                 880 


Lys Ile Ser Leu Lys Glu Leu Lys Glu Tyr Ser Asn Lys Lys Asn Glu 
                885                 890                 895     


Ile Glu Lys Asn Tyr Arg Met Gln Gln Asn Leu His Arg Lys Tyr Ala 
            900                 905                 910         


Arg Pro Lys Lys Asp Glu Lys Phe Asn Asp Lys Asp Tyr Lys Glu Tyr 
        915                 920                 925             


Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys Asn Lys 
    930                 935                 940                 


Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu Lys Ile 
945                 950                 955                 960 


Leu His Arg Ile Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp Leu Arg 
                965                 970                 975     


Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu Glu Ile 
            980                 985                 990         


Phe Asn Phe Asp Asn Ser Lys Asn  Val Lys Tyr Lys Ser  Gly Gln Ile 
        995                 1000                 1005             


Val Glu  Lys Tyr Ile Asn Phe  Tyr Lys Glu Leu Tyr  Lys Asp Asn 
    1010                 1015                 1020             


Val Glu  Lys Arg Ser Ile Tyr  Ser Asp Lys Lys Val  Lys Lys Leu 
    1025                 1030                 1035             


Lys Gln  Glu Lys Lys Asp Leu  Tyr Ile Arg Asn Tyr  Ile Ala His 
    1040                 1045                 1050             


Phe Asn  Tyr Ile Pro His Ala  Glu Ile Ser Leu Leu  Glu Val Leu 
    1055                 1060                 1065             


Glu Asn  Leu Arg Lys Leu Leu  Ser Tyr Asp Arg Lys  Leu Lys Asn 
    1070                 1075                 1080             


Ala Val  Met Lys Ser Val Val  Asp Ile Leu Lys Glu  Tyr Gly Phe 
    1085                 1090                 1095             


Val Ala  Thr Phe Lys Ile Gly  Ala Asp Lys Lys Ile  Gly Ile Gln 
    1100                 1105                 1110             


Thr Leu  Glu Ser Glu Lys Ile  Val His Leu Lys Asn  Leu Lys Lys 
    1115                 1120                 1125             


Lys Lys  Leu Met Thr Asp Arg  Asn Ser Glu Glu Leu  Cys Glu Leu 
    1130                 1135                 1140             


Val Lys  Val Met Phe Glu Tyr  Lys Met Lys Glu Lys  Lys Ser Glu 
    1145                 1150                 1155             


Asn 
    


<210>  779
<211>  1145
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  779

Met Cys Met Lys Ile Thr Lys Ile Asp Gly Ile Ser His Lys Lys Tyr 
1               5                   10                  15      


Lys Glu Lys Gly Lys Leu Ile Lys Asn Asn Asp Thr Ala Lys Asp Ile 
            20                  25                  30          


Ile Glu Glu Arg Phe Asn Asp Ile Glu Lys Lys Thr Lys Glu Leu Phe 
        35                  40                  45              


Gln Lys Thr Leu Asp Phe Tyr Val Lys Asn Tyr Glu Lys Cys Lys Glu 
    50                  55                  60                  


Gln Asn Lys Glu Arg Arg Glu Lys Ala Lys Asn Tyr Phe Ser Lys Val 
65                  70                  75                  80  


Lys Ile Leu Val Asp Asn Lys Lys Ile Thr Ile Cys Asn Glu Asn Thr 
                85                  90                  95      


Glu Lys Met Glu Ile Glu Asp Phe Asn Glu Tyr Asp Val Arg Ser Gly 
            100                 105                 110         


Lys Tyr Phe Asn Val Leu Asn Lys Ile Leu Asn Gly Glu Asn Tyr Thr 
        115                 120                 125             


Glu Glu Asp Leu Glu Val Phe Glu Asn Asp Leu Gln Lys Arg Thr Gly 
    130                 135                 140                 


Arg Ile Lys Ser Ile Lys Asn Ser Leu Glu Glu Asn Lys Ala His Phe 
145                 150                 155                 160 


Lys Lys Glu Ser Ile Asn Asn Asn Ile Ile Tyr Asp Arg Val Lys Gly 
                165                 170                 175     


Asn Asn Lys Lys Ser Leu Phe Tyr Glu Tyr Tyr Arg Ile Ser Ser Lys 
            180                 185                 190         


His Gln Glu Tyr Val Asn Asn Ile Phe Glu Ala Phe Asp Lys Leu Tyr 
        195                 200                 205             


Ser Asn Ser His Glu Ala Met Asn Asn Leu Phe Ser Glu Ile Thr Lys 
    210                 215                 220                 


Asp Ser Lys Asp Arg Asn Ile Arg Lys Ile Arg Glu Ala Tyr His Glu 
225                 230                 235                 240 


Ile Leu Asn Lys Asn Lys Thr Glu Phe Gly Glu Glu Leu Tyr Lys Lys 
                245                 250                 255     


Ile Gln Asp Asn Arg Asn Asn Phe Asp Lys Leu Leu Glu Ile Glu Pro 
            260                 265                 270         


Glu Ile Lys Glu Leu Thr Lys Ser Gln Ile Phe Tyr Lys Tyr Tyr Ile 
        275                 280                 285             


Asp Lys Val Asn Leu Asp Glu Thr Ser Ile Lys His Cys Phe Cys His 
    290                 295                 300                 


Leu Val Glu Ile Glu Val Asn Gln Leu Leu Lys Asn Tyr Val Tyr Ser 
305                 310                 315                 320 


Lys Arg Asn Ile Asn Lys Glu Lys Leu Glu Asn Ile Phe Glu Tyr Cys 
                325                 330                 335     


Lys Leu Lys Asn Leu Ile Lys Asn Lys Leu Val Asn Lys Leu Asn Asn 
            340                 345                 350         


Tyr Ile Arg Asn Cys Gly Lys Tyr Asn Ala Tyr Ile Ser Asn Asn Asp 
        355                 360                 365             


Val Val Val Asn Ser Glu Lys Ile Ser Glu Ile Arg Thr Lys Glu Ala 
    370                 375                 380                 


Phe Leu Arg Ser Ile Ile Gly Val Ser Ser Ser Ala Tyr Phe Ser Leu 
385                 390                 395                 400 


Arg Asn Ile Leu Asn Thr Asp Asn Thr Gln Asp Ile Thr Asn Lys Val 
                405                 410                 415     


Asp Lys Glu Val Asp Lys Leu Tyr Gln Glu Asn Lys Lys Ile Glu Leu 
            420                 425                 430         


Glu Glu Arg Leu Lys Leu Phe Phe Gly Asn Tyr Phe Asp Ile Asn Asn 
        435                 440                 445             


Gln Gln Glu Ile Lys Val Phe Leu Met Asn Ile Asp Lys Ile Ile Ser 
    450                 455                 460                 


Ser Ile Arg His Glu Ile Ile His Phe Lys Met Glu Thr Asn Ala Gln 
465                 470                 475                 480 


Asn Ile Phe Asp Phe Asn Asn Val Asn Leu Gly Asn Thr Ala Lys Asn 
                485                 490                 495     


Ile Phe Ser Asn Glu Ile Asn Glu Glu Lys Ile Lys Phe Lys Ile Phe 
            500                 505                 510         


Lys Gln Leu Asn Ser Ala Asn Val Phe Asp Tyr Leu Ser Asn Lys Asp 
        515                 520                 525             


Ile Thr Glu Tyr Met Asp Lys Val Val Phe Ser Phe Thr Asn Arg Asn 
    530                 535                 540                 


Val Ser Phe Val Pro Ser Phe Thr Lys Ile Tyr Asn Arg Val Gln Asp 
545                 550                 555                 560 


Leu Ala Asn Ser Leu Glu Ile Lys Lys Trp Lys Ile Pro Asp Lys Ser 
                565                 570                 575     


Glu Gly Lys Asp Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly 
            580                 585                 590         


Lys Phe Leu Asp Glu Phe Leu Asn Glu Glu Asn Gly Ile Phe Ile Ser 
        595                 600                 605             


Ile Lys Asp Lys Ile Ile Glu Leu Asn Arg Asn Gln Asn Lys Arg Thr 
    610                 615                 620                 


Gly Phe Tyr Lys Leu Glu Lys Phe Glu Lys Ile Glu Glu Thr Asn Pro 
625                 630                 635                 640 


Lys Lys Tyr Leu Glu Ile Ile Gln Ser Leu Tyr Met Ile Asn Ile Glu 
                645                 650                 655     


Glu Ile Asp Ser Glu Gly Lys Asn Ile Phe Leu Asp Phe Ile Gln Lys 
            660                 665                 670         


Ile Phe Leu Lys Gly Phe Phe Glu Phe Ile Lys Asn Asn Tyr Asn Tyr 
        675                 680                 685             


Leu Leu Glu Leu Lys Lys Ile Gln Asp Lys Lys Asn Ile Phe Asp Ser 
    690                 695                 700                 


Glu Met Ser Glu Tyr Ile Ala Gly Glu Lys Thr Leu Glu Asp Ile Gly 
705                 710                 715                 720 


Glu Ile Asn Glu Ile Ile Gln Asp Ile Lys Ile Thr Glu Ile Asp Lys 
                725                 730                 735     


Ile Leu Asn Gln Thr Asp Lys Ile Asn Cys Phe Tyr Leu Leu Leu Lys 
            740                 745                 750         


Leu Leu Asn Tyr Lys Glu Ile Thr Glu Leu Lys Gly Asn Leu Glu Lys 
        755                 760                 765             


Tyr Gln Ile Leu Ser Lys Thr Asn Val Tyr Glu Lys Glu Leu Met Leu 
    770                 775                 780                 


Leu Asn Ile Val Asn Leu Asp Asn Asn Lys Val Lys Ile Glu Asn Phe 
785                 790                 795                 800 


Lys Ile Leu Ala Glu Glu Ile Gly Lys Phe Ile Glu Lys Ile Asn Ile 
                805                 810                 815     


Glu Glu Ile Asn Lys Asn Lys Lys Ile Lys Thr Phe Glu Glu Leu Arg 
            820                 825                 830         


Asn Phe Glu Lys Gly Glu Asn Thr Gly Glu Tyr Tyr Asn Ile Tyr Ser 
        835                 840                 845             


Asp Asp Lys Asn Ile Lys Asn Ile Arg Asn Leu Tyr Asn Ile Lys Lys 
    850                 855                 860                 


Tyr Gly Met Leu Asp Leu Leu Glu Lys Ile Ser Glu Lys Thr Asn Tyr 
865                 870                 875                 880 


Cys Ile Lys Lys Lys Asp Leu Glu Glu Tyr Ser Glu Leu Arg Lys Gln 
                885                 890                 895     


Leu Glu Asp Glu Lys Thr Asn Phe Tyr Lys Ile Gln Glu Tyr Leu His 
            900                 905                 910         


Ser Lys Tyr Gln Gln Lys Pro Lys Lys Ile Leu Leu Lys Asn Asn Lys 
        915                 920                 925             


Asn Asp Tyr Glu Lys Tyr Lys Lys Ser Ile Glu Asn Ile Glu Lys Tyr 
    930                 935                 940                 


Val His Leu Lys Asn Lys Ile Glu Phe Asn Glu Leu Asn Leu Leu Gln 
945                 950                 955                 960 


Ser Leu Leu Leu Lys Ile Leu His Arg Leu Val Gly Phe Thr Ser Ile 
                965                 970                 975     


Trp Glu Arg Asp Leu Arg Phe Arg Leu Ile Gly Glu Phe Pro Asp Glu 
            980                 985                 990         


Leu Asp Val Glu Asp Ile Phe Asp  His Arg Lys Arg Tyr  Lys Gly Thr 
        995                 1000                 1005             


Gly Lys  Gly Ile Cys Lys Lys  Tyr Asp Arg Phe Ile  Asn Thr His 
    1010                 1015                 1020             


Thr Glu  Tyr Lys Asn Asn Asn  Lys Met Glu Asn Val  Lys Phe Ala 
    1025                 1030                 1035             


Asp Asn  Asn Pro Val Arg Asn  Tyr Ile Ala His Phe  Asn Tyr Leu 
    1040                 1045                 1050             


Pro Asn  Pro Lys Tyr Ser Ile  Leu Lys Met Met Glu  Lys Leu Arg 
    1055                 1060                 1065             


Lys Leu  Leu Asp Tyr Asp Arg  Lys Leu Lys Asn Ala  Val Met Lys 
    1070                 1075                 1080             


Ser Ile  Lys Asp Ile Leu Glu  Glu Tyr Gly Phe Lys  Ala Glu Phe 
    1085                 1090                 1095             


Ile Ile  Asn Ser Asp Lys Glu  Ile Ile Leu Asn Leu  Val Lys Ser 
    1100                 1105                 1110             


Val Glu  Ile Ile His Leu Gly  Lys Glu Asp Leu Lys  Ser Arg Arg 
    1115                 1120                 1125             


Asn Ser  Glu Asp Leu Cys Lys  Leu Val Lys Ala Met  Leu Glu Tyr 
    1130                 1135                 1140             


Ser Lys  
    1145 


<210>  780
<211>  1218
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  780

Met Arg Ile Val Arg Pro Tyr Gly Glu Ser Val Ala Pro Gly Ala Gly 
1               5                   10                  15      


Ser Glu Arg Leu Leu Arg Pro Lys Lys Gln Leu Arg Asp Gln Ile Gly 
            20                  25                  30          


Asp Ala Asp Arg Arg Ile Pro Thr Phe Ala Ala Gly His Asp Glu Leu 
        35                  40                  45              


Val Ile Ala Gln Trp Ile Ser Thr Ile Asp Lys Ile Ala Thr Lys Pro 
    50                  55                  60                  


Lys Gly Asn Lys Glu Pro Thr Pro Arg Gln Arg Ala Leu Arg Glu Lys 
65                  70                  75                  80  


Leu Gly Lys Ala Gly Trp Asp Arg Leu Val Asp Gln Lys Leu Leu Pro 
                85                  90                  95      


Gly Leu Pro Lys Asp Gln Asp Asp Tyr Leu Gly Lys Leu Trp Trp Phe 
            100                 105                 110         


Lys Ile His Pro Tyr Pro Lys Gly Thr Lys Ala Pro Lys Val Val Asn 
        115                 120                 125             


Gly Arg Glu Ile Pro Asp Pro Arg Gly Arg Trp Tyr Ser Arg Phe Val 
    130                 135                 140                 


Cys Asp Val Ala Pro Asp Asp Ile Asp Ala Ala Thr Val Ala Ala Arg 
145                 150                 155                 160 


Val His Glu His Leu His Val Ala Glu Tyr Arg His Gly Thr Glu Gln 
                165                 170                 175     


Lys His Asp Lys Gly Arg Ile Glu Arg Arg Ala Arg Ser Ile Ala Lys 
            180                 185                 190         


Asn Thr Ala Ser Leu Ala Gln Val Thr Lys Glu Arg Pro Thr Trp Thr 
        195                 200                 205             


Glu Asp Asp Val Ala Thr Tyr Ala Gln Thr Ala Gly Asp Val Ala Thr 
    210                 215                 220                 


Ala Ile Lys Gln Ala Ala Glu Ala Arg Glu Ala Asp Asn Arg Arg Val 
225                 230                 235                 240 


Gly Ala Asp Val Ala Ala Glu Val Leu Tyr Pro Ala Phe Gly Lys Leu 
                245                 250                 255     


Phe Pro Asn Lys Gly Ile Lys Glu Leu Glu Asn Gln Ser Gly Leu Pro 
            260                 265                 270         


Ala Leu His Leu Ala Ile Arg Asp Phe Tyr Gln Arg Arg Leu Lys Arg 
        275                 280                 285             


His Lys Lys Asp Gln Pro Glu His Lys Met Ala Arg Arg Lys Val Ser 
    290                 295                 300                 


Thr Leu Leu Pro Ala Asp Met Ala Gly Leu Ala Ala Met Leu Arg His 
305                 310                 315                 320 


Thr Ala Ala Asn Arg Asp Val Ala Ala Leu Val Arg Leu Gly Lys Val 
                325                 330                 335     


Ile His Tyr Glu Ala Ala Phe Ala Ala Gly Gln Lys Ala Ala Asp Gly 
            340                 345                 350         


Asp Ala Pro Ala His Val Leu Glu Lys Trp Pro Ala Glu Val Lys Ala 
        355                 360                 365             


Ser His Tyr Trp Ser Ser Glu Gly Gln Ala Glu Ile Lys Arg Asn Glu 
    370                 375                 380                 


Ala Phe Val Arg Ile Trp Arg His Ser Leu Ala Leu Ala Ala Gln Thr 
385                 390                 395                 400 


Leu Arg Asp Trp Ala Ser Pro Asp Gly Ser Phe His Thr Asp Ile Leu 
                405                 410                 415     


Ser Glu Lys Gln Phe Glu Thr Leu Thr Lys Asn Leu Asp Leu Asp His 
            420                 425                 430         


His Ala Arg Lys Leu Ala Val Leu Leu Gly Asn Arg Ala Glu Phe Phe 
        435                 440                 445             


Leu Lys Gly Arg Gly Asp Ala Phe Gln Lys Gln Thr Leu Lys Leu Ala 
    450                 455                 460                 


Leu Gln Gly Leu Thr Gln Leu Arg His Asn Ser Phe His Phe Asn Gly 
465                 470                 475                 480 


Arg Gly Gly Phe Ala Asp Ala Leu Lys Phe Thr Arg Lys Pro Glu Ile 
                485                 490                 495     


Thr Ala Asp Gln His Met Trp Asp Ala Leu Gly Ala Leu Trp Ala Thr 
            500                 505                 510         


Asp Leu Glu Glu Arg Gly Lys Arg Leu Ile Asp Thr Leu Glu Ala Ala 
        515                 520                 525             


His Leu His His Phe Phe Asp Trp Glu His Asn Lys Arg Leu Ile Gly 
    530                 535                 540                 


Ala Val Ala Arg Ala Lys Leu Ala Glu Gly Ala Glu Asp Leu Pro Leu 
545                 550                 555                 560 


Pro Arg Phe Arg Arg Leu Leu Asp Arg Ala Ala Asn Ile Arg Gly Lys 
                565                 570                 575     


Asp Gly Ile Asn Leu Arg Leu Pro Lys Pro Val Asn Arg Gln Asp Met 
            580                 585                 590         


Glu Asp Phe Pro Ala Leu His Ala Lys Tyr Val Ala Leu Lys Leu Leu 
        595                 600                 605             


Tyr Glu Asn Pro Phe Arg Gln Trp Val Gly His Arg Asp Arg Arg Asp 
    610                 615                 620                 


Leu Val Asn Lys Leu Ile Asp Arg Ala Val Arg Arg Ala Asp Lys Ala 
625                 630                 635                 640 


Ala Lys Asp Leu His Gly Lys Ala Asp Ala Asp Arg Arg Leu Ile Ile 
                645                 650                 655     


Thr Ala Lys Ala Lys Gly Leu Gly Arg Leu Gly Glu Gly Glu Lys Leu 
            660                 665                 670         


His Asp Phe Ala Phe Arg Leu Ser Arg Glu Thr Ala Ser Glu Met Arg 
        675                 680                 685             


Val Gln Arg Gly Tyr Asp Ser Asp Gly Glu Arg Ala Arg Glu Gln Ala 
    690                 695                 700                 


Ala Phe Ile Glu Glu Leu Leu Ile Asp Val Leu Ala Gln Ala Phe Asp 
705                 710                 715                 720 


His Tyr Leu Arg Lys Lys Lys Phe Asp Phe Leu Val Asp Leu Arg Ala 
                725                 730                 735     


Asp Glu Pro Arg Pro Lys Glu Pro Lys Cys Ala Leu Arg Arg Pro Val 
            740                 745                 750         


Leu Asp Ala Glu Gly Ala Ala Ala Pro Gln Trp Gln Val Leu Leu Tyr 
        755                 760                 765             


Phe Leu Leu His Leu Ile Pro Val Asp Asp Ile Gly Arg Leu Val His 
    770                 775                 780                 


Gln Ile Arg Lys Trp Asp Ile Thr Ala Gly Lys Ala Ala Gly Thr Thr 
785                 790                 795                 800 


Arg Ala Ala Asp Asp Asp Val Asp Arg Val Ala Arg Thr Leu Thr Leu 
                805                 810                 815     


Tyr Leu Asp Met His Asp Ala Lys Phe Thr Gly Asp Gln Ala Leu Gln 
            820                 825                 830         


Ala Leu Ala Pro Leu His Glu Leu Tyr Ala Ser Lys Glu Thr Phe Glu 
        835                 840                 845             


Arg Phe Phe Leu Arg Lys Ala Thr Asp Asp Asn Glu Tyr Leu Pro Arg 
    850                 855                 860                 


Arg Gly Leu Arg Glu Ile Leu Arg Phe Gly His Leu Pro Pro Leu Arg 
865                 870                 875                 880 


Ala Ile Phe Ala Ala His Lys Val Asp Asp Asp Thr Val Gln Lys Val 
                885                 890                 895     


Glu Ala Ala Glu Lys Gly Pro Leu Val Ala Ala Gln Arg Glu Arg Glu 
            900                 905                 910         


Arg Leu His Lys Leu Trp Val Asp Gln Arg Arg Lys Leu Gly Ala Glu 
        915                 920                 925             


Asp Leu Arg Cys Tyr Val Asp Thr Leu Ala Glu Val Thr Arg His Arg 
    930                 935                 940                 


His Ala Ala Ala His Val Arg Leu Val Asp His Val Glu Leu His Arg 
945                 950                 955                 960 


Leu Met Leu Ala Val Leu Gly Arg Leu Leu Asp Phe Ala Gly Leu Phe 
                965                 970                 975     


Glu Arg Asp Leu Tyr Phe Ala Met Leu Ala Leu Ile Tyr Arg Ala Pro 
            980                 985                 990         


Ser Ser Pro Gln Ala Val Leu Asp  Glu Ala Asp Arg Glu  Leu Leu Arg 
        995                 1000                 1005             


Arg Gly  Gln Ile Val Glu Thr  Trp Arg Lys Leu Gln  Asp Ser Thr 
    1010                 1015                 1020             


Leu Lys  Asp Glu Leu Ala Gln  Leu Phe Asp Pro Thr  Ser Gly Arg 
    1025                 1030                 1035             


Val Ile  Arg Val Arg Asn Asp  Phe Ala His Phe Asn  Met Leu Asn 
    1040                 1045                 1050             


Pro Arg  Arg Ser Arg Gly Ala  Thr Ile Asp Leu Thr  Ala Gln Val 
    1055                 1060                 1065             


Asn Ala  Ala Arg Arg Leu Met  Gly Tyr Asp Arg Lys  Leu Lys Asn 
    1070                 1075                 1080             


Ala Val  Ala Gln Ser Val Ile  Glu Leu Val Ala Arg  Glu Gly Leu 
    1085                 1090                 1095             


His Leu  Asp Trp Gly Met Gln  Val Leu Asp Gly Ala  His Val Leu 
    1100                 1105                 1110             


Val Asp  Ala Arg Val Arg Gly  Lys Gln Ala Ala His  Leu Gly Asn 
    1115                 1120                 1125             


Leu Gly  Leu Phe Glu Lys Gly  Gln Gly Glu Arg Glu  Lys Lys Pro 
    1130                 1135                 1140             


Ala His  Arg Leu Thr Glu Thr  Leu Ser Gly Pro His  Leu Ala Glu 
    1145                 1150                 1155             


Met Ala  Ala Thr Leu Phe Ala  Gly Arg Val Ala His  Ala Thr Asp 
    1160                 1165                 1170             


Ala Ala  Ala Leu Pro Arg Ala  Ala Ile Asp Trp Gln  Arg Ser Ala 
    1175                 1180                 1185             


Ala Pro  Glu Thr Asn Thr Lys  Gln Ala His Asn His  Pro Gln Arg 
    1190                 1195                 1200             


Pro Pro  Lys Pro Arg Ile Gln  Arg Pro Pro Leu Gln  Ala Ala Lys 
    1205                 1210                 1215             


<210>  781
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  781

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  782
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  782

Met Lys Ile Thr Lys Ile Asp Gly Ile Ser His Lys Lys Tyr Ile Lys 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Lys Thr Asp Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Thr Ile Arg Leu Asp Thr Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Glu Phe Phe Ser Asn Lys Val Leu Tyr Leu Lys Asp Gly Ile Leu 
65                  70                  75                  80  


Tyr Leu Lys Asp Arg Arg Glu Lys Asn Gln Leu Gln Asn Lys Asn Tyr 
                85                  90                  95      


Ser Glu Gln Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Asn Asp Phe Glu Lys Lys Leu Asp Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Leu Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Ile Lys Lys Val Glu Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Phe Tyr Asn Tyr Tyr Lys Asp Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Ile Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Asn Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Thr Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Met 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asn Val Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Ser Lys Glu Lys Leu Asn Asp Glu 
        275                 280                 285             


Asn Ile Lys Tyr Val Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Ser Phe Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asn Phe Ile 
        355                 360                 365             


Val Gly Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Ile Lys Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Ile Ser Gly Glu Ile Asp Lys Leu Tyr Asp 
            420                 425                 430         


Asn Asn Lys Gln Asn Glu Val Lys Lys Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Ser Lys Asn Glu Ile Glu Asp Phe Phe Ser 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Thr Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Ala Phe Ser Asp Gln Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Lys 
        915                 920                 925             


Asn Tyr Lys Arg Ala Ile Lys Asn Ile Glu Glu Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Arg Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asn Asn Lys  Gln Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Lys Phe Tyr Lys Glu  Leu Tyr Gln 
    1010                 1015                 1020             


Asn Asp  Glu Thr Lys Ile Asn  Lys Tyr Ser Ser Ala  Asn Ile Lys 
    1025                 1030                 1035             


Val Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Lys Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Lys Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Lys  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  783
<211>  1330
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  783

Met Lys Arg Glu Lys Asn Ile Thr Ile Met Lys Ile Ser Lys Val Asn 
1               5                   10                  15      


His Arg Arg Thr Ala Val Ala Leu Asn Gly Asp Lys Ser Glu Leu Gly 
            20                  25                  30          


Gly Ile Leu Tyr Glu Ala Pro Val Gln Lys Asp Arg Asn Gly Asn Tyr 
        35                  40                  45              


Asn Asp Val Ile Ala Glu Thr Gly Lys Val Val Asn Glu Ala Leu Asp 
    50                  55                  60                  


Lys Lys Ser Arg Leu Tyr Thr Pro Phe Asn Asn Gln Lys Val Ile Ile 
65                  70                  75                  80  


Asp Lys Asn Leu Gln Arg Tyr Ala Asn Asn Leu Lys Arg Cys Tyr Ile 
                85                  90                  95      


Asn Phe Val Lys Gln Tyr Val Asn Asn Lys Ser Phe Asn Tyr Lys Ala 
            100                 105                 110         


Met Gln Phe Ile Pro Asp Ile Gln Asn Pro Lys Thr Asn Asp Ala Val 
        115                 120                 125             


Asn Tyr Arg Thr Asp Arg Asp Asn Val Tyr Asn Lys Asn Lys Tyr Tyr 
    130                 135                 140                 


Asp Lys Gln Thr Lys Ser Lys Ser Lys Lys Phe Ile Tyr Glu Lys Ile 
145                 150                 155                 160 


Val Ile Pro Gln Asn Glu Gln Asn Ile Val Ile Ser Ala Leu Val Asn 
                165                 170                 175     


Cys Ser Leu Arg Lys Ser Leu Arg Lys Asp Val Ser Tyr Lys Thr Lys 
            180                 185                 190         


Thr Gly Glu Ile Lys Thr Tyr Asn Leu Pro Glu Leu Val Lys Lys Ser 
        195                 200                 205             


Met Arg Phe Tyr Cys Leu Glu Gly Gln Arg Glu Pro Asp Glu Lys Glu 
    210                 215                 220                 


Lys Tyr Glu Met Tyr Ile Leu Phe Ser Tyr Met Lys Glu Asp Lys Arg 
225                 230                 235                 240 


Thr Lys Asn Thr Asp Leu Leu Val Lys Ser Ile Ser Asn Gln Asn Thr 
                245                 250                 255     


Lys Val Lys Val Glu Asp Ile Asp Gly Asn Lys Leu Leu Lys Leu Ser 
            260                 265                 270         


Ile Ala Asp Thr Lys Lys Lys Pro Leu Trp Glu Tyr Leu Ile Lys Tyr 
        275                 280                 285             


Ala Asp Ser Ser Arg Gln Arg Glu Leu Met Tyr Asp Ile Arg Lys Lys 
    290                 295                 300                 


Ile Val Leu Tyr Val Ala Gly Ile Glu Glu Tyr Glu Asn Ile Lys Glu 
305                 310                 315                 320 


Asp Ser Gly Leu Ser Lys Val Ser Trp Ser Lys Tyr Asn Ile Ser Asp 
                325                 330                 335     


Asn Lys Met Phe Phe Asp Ile Asn Ser Cys Thr Asp Lys Arg Lys Gln 
            340                 345                 350         


Asn Leu Glu Ile Lys Ile Arg Glu Ala Asn Ile Glu His Tyr Arg Asn 
        355                 360                 365             


Ala Ser Ser Lys Leu Cys Asp Asp Glu Ser Ile Phe Trp Phe Gln His 
    370                 375                 380                 


Phe Glu Gly Val Ile Glu Thr Leu Phe Ser Lys Lys Ser Lys Ile Ser 
385                 390                 395                 400 


Glu Glu Arg Leu Gly Cys Ala Tyr Ile Cys Asp Tyr Leu Trp Lys Asp 
                405                 410                 415     


Phe Leu Ser Tyr Leu Ala Ala Lys Tyr Ile Asp Leu Gly Lys Gly Val 
            420                 425                 430         


Tyr His Phe Thr Met Lys Asp Lys Leu Asp Met Leu Asn Lys Asn Glu 
        435                 440                 445             


Ala Val Thr Asp Leu Arg Phe Gly Ile Val Ser Glu Lys Tyr Glu Lys 
    450                 455                 460                 


Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Glu Leu 
465                 470                 475                 480 


Asp Arg Asn Ile Ala Ala Tyr Val Thr Phe Ala Ala Asp Ile Phe Ala 
                485                 490                 495     


Lys Ser Val Ile Lys Ser Asp Tyr Arg Thr Lys Lys Asp Asn Asn Ser 
            500                 505                 510         


Asp Val Leu Gln Tyr Ser Asp Lys Glu Phe Arg Asn Ser Glu Val Ile 
        515                 520                 525             


Arg Asp Asn Ala Glu Lys Asn Ile Leu Gln Tyr Trp Gly Gly Tyr Ser 
    530                 535                 540                 


Arg Trp Gly Thr Glu Asn Ser Lys Leu Pro Glu Asn Asn Lys Val Ser 
545                 550                 555                 560 


Asp Phe Gly Lys Leu Asp Val Ser Asp Leu Cys Ile Asp Ile Lys Lys 
                565                 570                 575     


His Leu Ala Gly Ile Arg Asn Ser Ser Val His Tyr Thr Thr Lys Ile 
            580                 585                 590         


Lys Asn Glu Ser Ala Ala Asp Gly Ser Asn Val Lys Ile Leu Phe Glu 
        595                 600                 605             


Lys Asp Leu Ala Asp Ile Asn Ile Ile Tyr Ala Asp Lys Tyr Tyr Ser 
    610                 615                 620                 


Asn Asn Val Trp Met Phe Tyr Ser Leu Glu Asp Ile Asn Lys Leu Ile 
625                 630                 635                 640 


Ala Phe Leu Tyr Lys Glu Lys Arg Val Ile Arg Gln Val Gln Ile Pro 
                645                 650                 655     


Ser Phe Ser Arg Ile Leu Lys Arg Lys Ala Met Gln Asp Val Ile Asn 
            660                 665                 670         


Glu Ile Phe Lys Asp Asp Phe Asp Glu Asn Ile Val Asn Pro Glu Leu 
        675                 680                 685             


Lys Glu Lys Tyr Arg Asn Ser Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
    690                 695                 700                 


Tyr Asn Ala Phe Ile Ile Gln Pro Glu Leu Lys Glu Lys Phe Lys Asp 
705                 710                 715                 720 


Lys Ile Lys Thr Met Lys Ser Glu Leu Tyr Asn Lys Leu Lys Thr Ile 
                725                 730                 735     


Asp Lys Lys Glu Tyr Lys Ala Leu Tyr Cys Met Leu Ser Asn Glu Glu 
            740                 745                 750         


Ser Ala Leu Lys Asn Phe Ala Asp Arg Ile Tyr Ser Val Asp Gly Asp 
        755                 760                 765             


Asn Val Ser Phe Ala Asp Ile Cys Lys Ile Leu Met Thr Asp Tyr Asn 
    770                 775                 780                 


Met Gln Asn Gln Glu Lys Lys Asn Ile Glu Ser Met Glu Gln Lys Lys 
785                 790                 795                 800 


Lys Asn Lys Gly Lys Asp Glu Asn Tyr Lys His Phe Pro Leu Leu Leu 
                805                 810                 815     


His Lys Val Leu Lys Glu Leu Phe Ile Glu Tyr Leu Lys Gln Thr His 
            820                 825                 830         


Glu Leu Glu Phe Leu Arg Asn Asn Ile Cys Ile Lys Ser Asp Val Thr 
        835                 840                 845             


Met Glu Ser Phe Glu Ser Gln Ile Lys Gly Val Glu Ile Tyr Lys Asp 
    850                 855                 860                 


Leu Lys Glu Lys Ile Asp Lys Asn Asn Ser Leu Leu Asp Trp Tyr Val 
865                 870                 875                 880 


Ile Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asn 
                885                 890                 895     


Ile Lys Asn Tyr Ile Gln Phe Ala Thr Asn Ile Asp Lys Arg Ala Glu 
            900                 905                 910         


Ser Val Lys Asn Leu Thr Glu Ser Gly Met Val Lys Arg Ile Gln Tyr 
        915                 920                 925             


Tyr Asp Asp Ile Val Arg Thr Leu Glu Phe Ser Ala Gln Tyr Ile Gly 
    930                 935                 940                 


Lys Ile Ser Asn Asn Ile Asn Asp Tyr Phe Asn Ser Glu Asp Glu Tyr 
945                 950                 955                 960 


Val Ser Phe Leu Ser Lys Tyr Val Gly Phe Ile Asn Asp Lys Ser Glu 
                965                 970                 975     


Asp Val Leu Thr Glu Leu Lys Asp Phe Cys Arg Glu Lys Ile Asn Asn 
            980                 985                 990         


Gly Ser Gln Ile Ile Gly Ile Tyr  Tyr Gly Gly Asp Asn  Val Ile Ile 
        995                 1000                 1005             


Asn Arg  Asn Val Ile Tyr Ala  Gln Met Tyr Ser Asn  Ala Glu Val 
    1010                 1015                 1020             


Phe Ser  Asn Ile Tyr Lys Lys  Val Thr Lys Asn Asp  Ile Ile Asn 
    1025                 1030                 1035             


Tyr Tyr  Glu Lys Gln Asn Asp  Leu Lys Asp Val Phe  Lys Ser Gly 
    1040                 1045                 1050             


Val Cys  Gln Asn Glu Asp Glu  Gln Arg Ser Leu Cys  Glu Phe Gln 
    1055                 1060                 1065             


Gln Leu  Lys Asn Arg Ile Glu  Leu Thr Glu Leu Ser  Thr Tyr Ala 
    1070                 1075                 1080             


Asp Met  Val Asn Asp Phe Met  Ala Gln Phe Val Glu  Trp Ala Tyr 
    1085                 1090                 1095             


Leu Arg  Glu Arg Asp Leu Met  Tyr Phe Gln Leu Gly  Ile His Tyr 
    1100                 1105                 1110             


Ile Arg  Leu Phe Tyr Ser Asp  Asn Val Leu Asp Glu  Lys Tyr His 
    1115                 1120                 1125             


Lys Leu  Ser Asp Asn Val Ile  Asp Ile Glu Glu Gly  Ala Leu Leu 
    1130                 1135                 1140             


Tyr Gln  Ile Val Ala Met Tyr  Asp Tyr Glu Leu Arg  Ile Phe Glu 
    1145                 1150                 1155             


Thr Asp  Asn Phe Gly Asn Ala  Lys Arg Ile Gly Gln  Gly Gly Pro 
    1160                 1165                 1170             


Gly Lys  Ser Ile Pro Val Phe  Leu Lys Lys Tyr Cys  Asn Gly Thr 
    1175                 1180                 1185             


Asp Val  Tyr Glu Cys Gly Leu  Glu Leu Phe Glu Asp  Ile Asn Gln 
    1190                 1195                 1200             


His Glu  His Ile Ile Arg Phe  Arg Asn Asp Ile Ala  His Met Arg 
    1205                 1210                 1215             


Tyr Met  Ser Asn Gln Ala Met  Asn Ile Met Ser Ile  Val Ser Asn 
    1220                 1225                 1230             


Ile Tyr  Lys Ser Phe Phe Val  Tyr Asp Thr Lys Leu  Lys Lys Ser 
    1235                 1240                 1245             


Ile Ser  Leu Val Phe Lys Asn  Ile Leu Met Arg Tyr  Gly Val Ile 
    1250                 1255                 1260             


Ala Asp  Leu Val Phe Ser Tyr  Asn Asn Lys Asn Gln  Ser Ile Lys 
    1265                 1270                 1275             


Asp Asp  Met Asp Ile Asn Ile  Ile Asn Ile Lys Asn  Leu Lys Ser 
    1280                 1285                 1290             


Asp Lys  Tyr Val Tyr Lys Ile  Val Asn Glu Asp Ile  Val Lys Gln 
    1295                 1300                 1305             


Val Glu  Ile Glu Ile Arg Asn  Gln Val Phe Leu Glu  Gln Leu His 
    1310                 1315                 1320             


Lys Leu  Leu Tyr Phe Ser Arg  
    1325                 1330 


<210>  784
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  784

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Pro Gly Thr Asp Thr 
            20                  25                  30          


Ile Gly Leu Lys Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Asp Lys Pro Lys Lys 
    50                  55                  60                  


Trp Lys Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Glu Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Ser Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Met Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Tyr Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ser Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Gln Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Phe 
            660                 665                 670         


Ile Arg Lys Asn Phe Pro Glu Asp Ile Ser Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val Tyr Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Asp Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Asp Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asn  Ser Glu Lys Lys Glu  Ala Tyr Gln Lys Ile  Glu Val Asn 
    1100                 1105                 1110             


Gly Asp  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Val  Tyr Ala Pro Asp Glu  Lys Gly Asp 
    1130                 1135                 1140             


Ile Leu  Lys Glu Gln Cys Thr  Lys Gly Gly Ala Gly  Gly Lys Ile 
    1145                 1150                 1155             


Ser Ala  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Lys Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Lys Gln 
    1250                 1255                 1260             


Thr Thr  Ser Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Ser Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Lys  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Val Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Gly Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Pro Asn 
    1370                 1375                 1380         


<210>  785
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  785

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  786
<211>  1044
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  786

Leu Asp Leu Lys Glu Ile Phe Lys Lys Tyr Lys Asp Arg Lys Ile Asp 
1               5                   10                  15      


Leu Leu Leu Lys Ser Ile Asn Asn Asn Lys Ile Asn Leu Glu Tyr Lys 
            20                  25                  30          


Lys Glu Asn Val Asn Glu Glu Ile Tyr Glu Ile Asn Pro Thr Asn Asp 
        35                  40                  45              


Arg Glu Met Thr Phe Tyr Gly Leu Leu Lys Glu Ile Ile Glu Lys Lys 
    50                  55                  60                  


Asp Glu Gln Lys Ser Ile Leu Glu Glu Lys Leu Asp Asn Phe Asp Ile 
65                  70                  75                  80  


Thr Asn Phe Leu Glu Asn Ile Glu Lys Ile Phe Asn Glu Lys Ile Glu 
                85                  90                  95      


Val Asn Ile Ile Lys Gly Lys Val Leu Asn Glu Leu Arg Glu Tyr Ile 
            100                 105                 110         


Lys Glu Lys Glu Glu Asn Asn Ser Asp Asn Lys Leu Lys Gln Ile Tyr 
        115                 120                 125             


Asn Leu Glu Leu Lys Lys Tyr Ile Glu Asn Asn Phe Ser Tyr Lys Lys 
    130                 135                 140                 


Gln Lys Ser Lys Ser Lys Asn Gly Lys Asn Asp Asp Leu Tyr Leu Asn 
145                 150                 155                 160 


Phe Leu Lys Lys Ile Met Phe Ile Glu Glu Ala Asp Glu Lys Lys Glu 
                165                 170                 175     


Ile Asn Lys Glu Lys Phe Lys Asn Lys Ile Asn Ser Asn Phe Lys Asn 
            180                 185                 190         


Leu Phe Val Gln His Ile Leu Asp Tyr Gly Lys Leu Leu Tyr Tyr Lys 
        195                 200                 205             


Glu Asn Asp Glu Tyr Ile Lys Asn Thr Gly Gln Leu Glu Thr Lys Asp 
    210                 215                 220                 


Leu Glu Tyr Ile Lys Ala Lys Glu Thr Leu Ile Arg Lys Met Ala Val 
225                 230                 235                 240 


Leu Val Ser Phe Ala Ala Asn Ser Tyr Tyr Asn Leu Phe Gly Arg Thr 
                245                 250                 255     


Glu Asn Asn Ile Leu Thr Gln Glu Ile Ser Asp Asp Leu Leu Leu Gly 
            260                 265                 270         


Lys Ile Glu Asn Glu Ile Tyr Ile Lys Gly Glu Lys Asn Arg Arg Tyr 
        275                 280                 285             


Val Phe Lys Glu Lys Met Leu Asn Tyr Phe Phe Asn Pro Glu Ile Phe 
    290                 295                 300                 


Gly Asp Asn Lys Ile Val Glu Leu Leu Ser Ala Ile Ser Ser Ser Ile 
305                 310                 315                 320 


Tyr Asn Ile Arg Asn Gly Val Asn His Phe Asp Lys Met Ile Leu Gly 
                325                 330                 335     


Lys Tyr Asn Asn Gly Leu Asp Leu Lys Asp Ser Asn Thr Ile Lys Asp 
            340                 345                 350         


Tyr Phe Asn Phe Lys Lys Lys Glu Ile Gln Gln Asp Leu Lys Asp Arg 
        355                 360                 365             


Phe Ile Ser Asn Asn Leu Gln Tyr Tyr Tyr Thr Glu Asn Glu Ile Lys 
    370                 375                 380                 


Lys Tyr Phe Glu Lys Tyr Lys Phe Glu Ile Leu Lys Thr Lys Ala Ser 
385                 390                 395                 400 


Phe Ala Pro Asn Phe Lys Arg Ile Leu Thr Lys Gly Glu Asn Leu Ser 
                405                 410                 415     


Ile Ser Glu Ser Asn Asn Ser Tyr Glu Phe Phe Lys Ala Tyr Ser Glu 
            420                 425                 430         


Asn Ser Asp Lys Asn Thr Glu Tyr Asn Glu Phe Met Lys Thr Arg Asn 
        435                 440                 445             


Phe Leu Leu Lys Glu Leu Tyr Tyr Asn Asn Phe Tyr Thr Glu Phe Leu 
    450                 455                 460                 


Asn Asn Lys Ala Lys Phe Arg Glu Ala Val Glu Lys Val Lys Lys Asn 
465                 470                 475                 480 


Lys Lys Arg Arg Gly Gly Lys Ser Tyr Asp Val Ile Gly Asn Tyr Asn 
                485                 490                 495     


Phe Ser Asp Ser Ile Ser Glu Tyr Ile Ser Tyr Ile His Lys Ser Glu 
            500                 505                 510         


Met Glu Arg Ile Glu Ile Asn Thr Glu Lys Asn Arg Lys Asp Thr Ser 
        515                 520                 525             


Lys His Ile Arg Asp Phe Ile Glu Glu Ile Phe Leu Glu Gly Phe Ile 
    530                 535                 540                 


Glu Tyr Leu Asn Asn Asn Asn Phe Lys Phe Leu Lys Asn Arg Asn Glu 
545                 550                 555                 560 


Val Asp Lys Glu Arg Glu Glu Ile Val Arg Asn Leu Asn Ile Arg Ile 
                565                 570                 575     


Glu Gly Leu Asp Ile Leu Asn Glu Asp Asp Ser Glu Ile Leu Asn Leu 
            580                 585                 590         


Tyr Leu Phe Phe Asn Met Ile Asp Asn Lys Arg Ile Ser Glu Phe Arg 
        595                 600                 605             


Asn Asp Met Ile Lys Tyr Lys Gln Phe Leu Ala Lys Arg Gln Asn Ile 
    610                 615                 620                 


Asp Ser Lys Phe Leu Lys Ile Asp Ile Glu Lys Ile Glu Ala Ile Ile 
625                 630                 635                 640 


Glu Phe Val Ile Ile Thr Lys Glu Lys Leu Glu Ile Leu Glu Gly Glu 
                645                 650                 655     


Thr Lys Glu Gln Lys Lys Asp Asn Met Asn Ala Leu Phe Asn Lys Phe 
            660                 665                 670         


Tyr Ser Ser Glu Ser Glu Tyr Asp Glu Ser Leu Lys Lys Phe Ile Glu 
        675                 680                 685             


Glu Thr Val Leu Asn Asp Lys Lys Asn Thr Pro Phe Tyr Ser Thr Asp 
    690                 695                 700                 


Gly Lys Thr Pro Ile Val His Ser Asn Leu Glu Lys Met Pro Lys Tyr 
705                 710                 715                 720 


Gly Thr Glu Asn Phe Leu Ser Lys Val Leu Lys Asp Ser Lys Tyr Thr 
                725                 730                 735     


Leu Asn Asn Met Thr Ile Lys Glu Lys Phe Glu Ala Glu Val Ser Asp 
            740                 745                 750         


Glu Leu Lys Glu Tyr Lys Ile Leu Glu Lys Val Ser Arg Phe Lys Glu 
        755                 760                 765             


Asn Glu Lys Pro Lys Lys Val Ile Glu Tyr Tyr Asn Asp Cys Arg Cys 
    770                 775                 780                 


Tyr Leu His Lys Glu Trp Ile Lys Asn Lys Lys Asn Lys Glu Glu Phe 
785                 790                 795                 800 


Glu His Lys Glu Ile Tyr Lys Lys Ile Ile Glu Glu Ile Arg Lys Tyr 
                805                 810                 815     


Asn Tyr Leu Glu Asn Lys Glu Lys Leu Gln Asn Val Tyr Leu Leu His 
            820                 825                 830         


Glu Met Leu Ser Asp Leu Leu Ala Arg Asn Val Ala Phe Phe Asn Lys 
        835                 840                 845             


Trp Glu Arg Asp Phe Lys Phe Ile Val Ile Ala Ile Lys Gln Phe Leu 
    850                 855                 860                 


Arg Glu Asn Asp Lys Glu Lys Val Asn Glu Phe Leu Asn Pro His Lys 
865                 870                 875                 880 


Ser Asp Gly Ser Lys Asp Asn Phe Ser Val Thr Asn Tyr Arg Ser Lys 
                885                 890                 895     


Met Lys Ser Ile Ile Asn Asn Ile His Glu Asn Phe Met Ser Leu Leu 
            900                 905                 910         


Phe Leu Asn Asn Asn Leu Ala Thr Gly Gly Ile Gln Met Gly Arg Asn 
        915                 920                 925             


Asn Asn Phe Thr Trp Gly Asn Leu Arg Asn Tyr Ile Ala His Phe Glu 
    930                 935                 940                 


Tyr Leu His Lys Glu Lys Asp Thr Ile Ser Phe Leu Asn Gln Ala Asn 
945                 950                 955                 960 


Leu Leu Ile Lys Leu Phe Ser Tyr Asp Lys Lys Val Gln Asn His Ile 
                965                 970                 975     


Ile Lys Ser Met Lys Thr Leu Leu Glu Lys Tyr Asn Ile Glu Ile Gly 
            980                 985                 990         


Phe Glu Ile Ser Asn Asp Ser Glu  Glu Ile Phe Glu Tyr  Lys Ile Lys 
        995                 1000                 1005             


Tyr Ile  Asn Ser Lys Lys Gly  Lys Met Leu Gly Lys  Asn Asn Glu 
    1010                 1015                 1020             


Phe Glu  Ile Leu Glu Asn Glu  Phe Val Arg Asn Val  Lys Ala Leu 
    1025                 1030                 1035             


Leu Glu  Tyr Ser Lys Leu 
    1040                 


<210>  787
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  787

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Pro Gly Thr Asp Thr 
            20                  25                  30          


Ile Asp Leu Lys Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Lys Val Phe Asn Gln Ile Gln Val Gly Asn Lys Pro Lys Lys 
    50                  55                  60                  


Trp Lys Lys Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Glu Tyr Val Glu Ser Ser Gln Arg Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Glu Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Ser Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Met Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Tyr Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ser Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Lys Asp Arg Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Lys Glu Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Gln Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Phe 
            660                 665                 670         


Ile Arg Lys Asn Phe Pro Glu Asp Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Asp Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Asp Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asn  Ser Glu Lys Lys Glu  Ala Tyr Gln Lys Ile  Glu Val Asn 
    1100                 1105                 1110             


Gly Asp  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Val  Tyr Ala Pro Asp Glu  Lys Gly Asp 
    1130                 1135                 1140             


Ile Leu  Lys Glu Gln Cys Thr  Lys Gly Gly Ala Gly  Gly Lys Ile 
    1145                 1150                 1155             


Ser Ala  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Lys Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Lys Gln 
    1250                 1255                 1260             


Thr Thr  Ser Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Ser Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Lys  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Val Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Gly Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Pro Asn 
    1370                 1375                 1380         


<210>  788
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  788

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Asp Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn Tyr Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Gly Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Gly Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Lys Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Arg Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Asp Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  789
<211>  1101
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  789

Met Arg Ile Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Ile Tyr Ser Glu 
            20                  25                  30          


Gln Ala Val Ser Asn Glu Thr Asn Asn Ile Leu Pro Val Lys Lys Met 
        35                  40                  45              


Asp Ser Phe Asn Leu Ser Ile Leu Asn Lys Thr Ile Ile Lys Phe Glu 
    50                  55                  60                  


Thr Val Lys Lys Gln Lys Leu Asn Leu Asp Gln Tyr Lys Ile Val Glu 
65                  70                  75                  80  


Lys Ile Phe Lys Tyr Pro Lys Gln Glu Leu Pro Lys Gln Ile Asn Ala 
                85                  90                  95      


Glu Glu Ile Leu Gln Phe Leu Asn His Lys Phe Gln Glu Pro Val Lys 
            100                 105                 110         


Tyr Trp Lys Asn Gly Lys Glu Glu Ser Phe Asn Leu Thr Leu Leu Ile 
        115                 120                 125             


Val Glu Ala Val Lys Thr Gln Glu Lys Arg Lys Leu Gln Pro Tyr Tyr 
    130                 135                 140                 


Asp Trp Lys Thr Trp Tyr Ile Gln Thr Lys Ser Asp Leu Leu Lys Lys 
145                 150                 155                 160 


Ser Ile Glu Asn Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg 
                165                 170                 175     


Lys Lys Ala Leu Leu Ala Trp Glu Thr Glu Phe Thr Thr Ser Gly Ser 
            180                 185                 190         


Ile Asp Leu Thr His Phe His Lys Val Tyr Met Thr Asp Val Leu Cys 
        195                 200                 205             


Thr Ala Leu Gln Lys Val Glu Pro Ser Ala Asp Glu Arg Gly Lys Met 
    210                 215                 220                 


Asn Ser Asn Ala Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Asn His 
225                 230                 235                 240 


Gln Pro Ala Ile Phe Gly Thr Arg Glu Ala Pro Asn Glu Val Asn Arg 
                245                 250                 255     


Ala Asp Asn Gln Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu 
            260                 265                 270         


Glu His Tyr Phe Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Ala Asp 
        275                 280                 285             


Asp Ile Ser His Tyr Leu Lys Ala Gln Thr Leu Lys Thr Thr Ile Glu 
    290                 295                 300                 


Lys Gln Leu Val Asn Ala Ile Arg Ala Asn Ile Ile Gln Gln Gly Lys 
305                 310                 315                 320 


Thr Asn His His Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile 
                325                 330                 335     


Arg Ile Lys Thr Asn Glu Ala Phe Val Leu Asn Leu Ile Gly Thr Cys 
            340                 345                 350         


Ala Phe Ala Ala Asn Asn Ile Arg Asn Met Val Asp Lys Glu Gln Ile 
        355                 360                 365             


Ser Asp Ile Leu Gly Lys Arg Glu Phe Ile Asp Ser Leu Thr Lys Ser 
    370                 375                 380                 


Arg Ile Ser Ser Gln Leu Tyr Ser Phe Phe Phe Gly Glu Asn Leu Ser 
385                 390                 395                 400 


Thr Asn Lys Ala Glu Lys Glu Thr Gln Leu Trp Gly Ile Arg Gly Ala 
                405                 410                 415     


Val Gln Gln Ile Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu 
            420                 425                 430         


Thr Thr Ile Phe Asn Ile Cys Lys Phe Glu Asn Pro Thr Asp Ala Asp 
        435                 440                 445             


Pro Lys Gln Gln Thr Asn Tyr Val Asp Ser Ile Tyr Lys Thr Leu Phe 
    450                 455                 460                 


Ile Lys Glu Leu Glu Lys Ile Pro Glu Ala Phe Ala Gln Gln Leu Lys 
465                 470                 475                 480 


Thr Gly Gly Ala Leu Ser Tyr Tyr Thr Val Glu Asn Leu Lys Thr Leu 
                485                 490                 495     


Leu Thr Thr Phe Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala 
            500                 505                 510         


Pro Gly Phe Lys Lys Val Leu Asn Gly Gly Ile Asn Tyr Gln Asn Ala 
        515                 520                 525             


Lys Gln Asp Glu Ser Phe Tyr Glu Leu Met Leu Glu Arg Tyr Leu Arg 
    530                 535                 540                 


Lys Glu Asn Phe Ala Glu Glu Ala Tyr Asn Ala Arg Tyr Phe Leu Leu 
545                 550                 555                 560 


Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Lys Phe Thr Ala Asp Arg 
                565                 570                 575     


Lys Ala Phe Ala Asp Ser Val Gly Phe Val Gln Leu Gln Asn Arg Lys 
            580                 585                 590         


Gln Ala Glu Asn Ser Lys Arg Pro Lys Ala Phe Ala Phe Glu Ala Val 
        595                 600                 605             


Arg Pro Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala Tyr Val 
    610                 615                 620                 


Gln Ser Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys Ala Thr 
625                 630                 635                 640 


Asp Glu Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val Phe Ile 
                645                 650                 655     


Lys Gly Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe Val Gln 
            660                 665                 670         


Val Pro Gln Pro Gln Leu Thr Thr Thr Asp Ser Asn Gln Gln Lys Ala 
        675                 680                 685             


Asp Lys Leu Asn Gln Leu Glu Ala Ser Ile Thr Ala Asp Cys Lys Leu 
    690                 695                 700                 


Thr Ala Gln Tyr Ala Lys Thr Asp Asp Ala Thr His Ile Ala Phe Tyr 
705                 710                 715                 720 


Val Phe Cys Lys Leu Leu Asp Ala Gly His Leu Ser Asn Leu Arg Asn 
                725                 730                 735     


Glu Leu Ile Lys Phe Arg Gly Ser Val Lys Asp Phe Asp Phe His His 
            740                 745                 750         


Leu Leu Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val Val Pro 
        755                 760                 765             


Thr Asp Tyr Arg Asp Leu Tyr Ser Ser Gly Ala Asp Cys Leu Ala Arg 
    770                 775                 780                 


Leu Arg Pro Phe Ile Glu Gln Gly Ala Asp Ile Lys Asn Trp Ser Asp 
785                 790                 795                 800 


Leu Tyr Val Gln Thr Asp Lys Gln Thr Pro Val Ile His Ala Gly Ile 
                805                 810                 815     


Glu Leu Ser Val Lys Tyr Gly Thr Thr Ala Leu Leu Glu Gln Leu Ile 
            820                 825                 830         


Thr Cys Asn Pro Lys Phe Arg Val Met Glu Asp Asn Phe Thr Lys Trp 
        835                 840                 845             


Ser Ala Gln Lys Lys Glu Ile Glu Glu Lys Val Asn Lys His Thr Asn 
    850                 855                 860                 


Leu His Gln Gln Trp Val Glu Ala Lys Glu Lys Asp Asp Arg Glu Arg 
865                 870                 875                 880 


Val Lys Ser Lys Lys Asn Phe Val Arg Glu Tyr Val Lys Lys Asn Tyr 
                885                 890                 895     


Val Asp Tyr Ile Asn Asn Cys Ile Glu Ile Asn Asn Tyr Asn Trp Leu 
            900                 905                 910         


Asp Asn Lys Leu His Phe Val His Leu Asn His Leu His His Leu Thr 
        915                 920                 925             


Ile Asp Ile Leu Gly Arg Met Ala Gly Phe Val Ala Leu Trp Glu Arg 
    930                 935                 940                 


Asp Phe Gln Tyr Ile Thr Lys Tyr Thr Ala Ala Lys Glu Gly Thr Asp 
945                 950                 955                 960 


Ala Leu Ser Phe Asp Gly Gly Leu Pro Arg Leu Lys Asp Lys Gln Glu 
                965                 970                 975     


Tyr Tyr Asn Lys Leu Phe Leu Ser Asp Lys Tyr Thr Lys Val Arg Asn 
            980                 985                 990         


His Ile Ala His Phe Asn Tyr Leu  Thr Lys Asp Ala Ala  Asp Phe Ala 
        995                 1000                 1005             


Leu Leu  Asp Leu Ile Asn Glu  Leu Arg Glu Leu Leu  His Tyr Gly 
    1010                 1015                 1020             


Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ala Phe Ile  Asp Leu Phe 
    1025                 1030                 1035             


Glu Lys  His Gly Met Ile Leu  Lys Leu Lys Leu Asn  Thr Asp His 
    1040                 1045                 1050             


Gln Leu  Val Val Glu Ser Ile  Glu Pro Lys Lys Ile  Tyr His Leu 
    1055                 1060                 1065             


Gly Ser  Thr Ala Lys Asp Lys  Pro Glu Tyr Gln Tyr  Thr Thr Asn 
    1070                 1075                 1080             


Gln Val  Met Thr Val Tyr Cys  Asn Met Cys Arg Ser  Leu Leu Glu 
    1085                 1090                 1095             


Met Lys  Lys 
    1100     


<210>  790
<211>  1200
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  790

Met Asp Ala Asp Gly Leu Ser Ile Gly Pro Phe Ala Glu Ser His Asp 
1               5                   10                  15      


Ser Leu Val Ile Gly Gln Trp Ile Ser Thr Ile Asp Lys Ile Ala Thr 
            20                  25                  30          


Lys Pro Lys Gly Lys Gly Lys Ala Thr Gln Glu Gln Arg Asn Val Arg 
        35                  40                  45              


Ser Ala Leu Gly Ala Ala Cys Trp Ala Arg Leu Val His Pro Asp Gly 
    50                  55                  60                  


Thr Phe Gly Ala Leu Asp Ser Glu Arg Met Asn Trp Ala Arg Asn Thr 
65                  70                  75                  80  


Trp Glu Arg Arg Leu His Pro Tyr Ser Asp Lys Asn Phe Val Thr Asn 
                85                  90                  95      


Gly Arg Glu Lys Thr Pro Asp Ser Lys Ala His Trp Phe Asn Arg Phe 
            100                 105                 110         


Cys Lys Gly Leu Ser Val Gln Glu Val Thr Asp Pro Ser Val Ala Gly 
        115                 120                 125             


Asp Val Ala Gln Ser Ile Glu Glu His Leu Thr Lys Asp Ala Phe Arg 
    130                 135                 140                 


Arg Gly Gly Gly Thr Arg Arg Ser Pro Lys Ala Ser Ala Ser Arg Ala 
145                 150                 155                 160 


Gly Leu Ile Ala Val Arg Ala Asp Ser Ile Thr Lys Asn Ala Leu Arg 
                165                 170                 175     


Phe Pro Gly Ala Asp Ile Ala Glu Gln Arg Glu His Gly Trp Thr Glu 
            180                 185                 190         


Glu Asp Ile Ala Arg Tyr Val Ala Lys Ser Asp Pro Val Ala Gln Ile 
        195                 200                 205             


Tyr Lys Ala Val Leu Asp Ala Glu Pro Asp Gly Gln Arg Val Arg Trp 
    210                 215                 220                 


Ser Ile Ala Ala Glu Arg Leu Tyr Ala His Tyr Ala Arg Val Phe Thr 
225                 230                 235                 240 


Ala Pro Asp Ile Val Leu Asp Arg Lys Asp Ala Asp Lys Ile Leu Arg 
                245                 250                 255     


Gly Val Leu Ala Leu His Glu Ala Leu Arg Gln Leu Tyr Arg His Arg 
            260                 265                 270         


Leu Lys Arg His Arg Arg Lys Pro Val His Val Thr Val Leu Leu Pro 
        275                 280                 285             


Arg Asp Ile Arg Asp Ala Leu Thr Met Ile Ser Arg Gln Gln Asp Asn 
    290                 295                 300                 


Ser Asp Leu Asn Ala Leu Val Arg Leu Gly Lys Val Ile His His Glu 
305                 310                 315                 320 


Ala Ala Asp Gln Ala Gly Val Glu Ser Val Ala Lys Ile Ile Gly Asn 
                325                 330                 335     


Trp Pro Glu Asp Val Ser Arg Ser Tyr Tyr Trp Thr Ser Asp Gly Gln 
            340                 345                 350         


Thr Glu Ile Lys Arg Thr Glu Ala Phe Val Arg Ala Trp Arg Gly Pro 
        355                 360                 365             


Ile Ala His Ala Gln Arg Thr Leu Ala Asp Trp Val Asp Pro Asp Arg 
    370                 375                 380                 


Leu Ser Val Lys Ser Asp Ser Ala Glu Ala Lys Pro Pro Asp Met Leu 
385                 390                 395                 400 


Gly Ala Lys Phe Asp Asp Ala Leu Ala Gln Leu Asp Asp Asp Ala Ala 
                405                 410                 415     


Ile Thr Lys Ala Arg Leu Leu Phe Gly Thr Arg Ser Asp Ala Leu Gly 
            420                 425                 430         


Gly Pro Asp Pro Lys Ala Val Leu Arg Leu Thr Lys Arg Ala Leu Ser 
        435                 440                 445             


Lys Leu Arg Asn Ala Ala Phe His Phe Lys Gly Met Gly Gly Phe Val 
    450                 455                 460                 


Gln Asp Met Thr Leu Lys Ile Leu Pro Ser Gly Ser Glu Asp Cys Glu 
465                 470                 475                 480 


Val Leu Glu Arg Val His Ala Leu Trp His Ala Asp Gln Lys Asp Arg 
                485                 490                 495     


Met Ile Arg Val Lys Asp Ala Leu Val Gly Ala His Ala Glu Val Tyr 
            500                 505                 510         


Leu Asn Gln Pro Gln Met Asn Gln Leu Trp Glu Leu Leu Gly Ala Gln 
        515                 520                 525             


Glu Ser Lys Ile Ala Leu Pro Arg Phe Asn Arg Val Ile Ala Arg Ala 
    530                 535                 540                 


Ala His Ala Trp Thr Ser Lys Glu Asp Arg Leu Ala Leu Pro Asp Ser 
545                 550                 555                 560 


Ala Ser Ser Lys Asp Leu Glu Ala Gln Pro Ala Arg Arg Cys Gln Tyr 
                565                 570                 575     


Val Leu Ile Lys Met Val Tyr Glu Arg Gly Phe Arg Thr Trp Leu Thr 
            580                 585                 590         


Ser Arg Ser Ala Asp Asp Leu Asn Ile Trp Ile Lys Gln Ala Thr Asp 
        595                 600                 605             


His Thr Thr Glu Ala Ala Lys Glu Phe His Lys His Gln Val Ser Lys 
    610                 615                 620                 


Glu Glu Leu Ala Gln Ile Ser Ala Arg Ser Ala Gly Leu Val Lys Leu 
625                 630                 635                 640 


Glu Pro Gly Glu Gly Phe Ala Lys Phe Leu Phe Lys Met Thr Ala Leu 
                645                 650                 655     


Thr Thr Thr Glu Phe Arg Val Gln Lys Gly Tyr Thr His Asp Ala Gly 
            660                 665                 670         


Arg Ala Arg Glu Gln Ala Ser Phe Leu Asp Asp Leu His Cys Asp Leu 
        675                 680                 685             


Val Ala Leu Ala Phe Asp Thr Tyr Leu Lys Asp Lys Lys Leu Gly Trp 
    690                 695                 700                 


Leu Tyr Arg Leu Arg Gln Asp Glu Ser Pro Gly Asn Pro Gln Ser Ser 
705                 710                 715                 720 


Ala Ala Asp Leu Pro Leu Gly Ser Val Ala Ser Ala Gln Asp Trp Gln 
                725                 730                 735     


Ala Val Leu Tyr Leu Val Leu His Leu Ile Pro Val Asp Asp Val Gly 
            740                 745                 750         


Arg Leu Leu His Arg Trp Arg Trp Trp Ser Asn Lys Tyr Asp Asp Glu 
        755                 760                 765             


His Leu Pro Ala Glu Gly Leu Gln Leu Ala Glu Ala Phe Thr Leu Tyr 
    770                 775                 780                 


Leu Asp Met His Asp Ala Lys Phe Asp Gly Ala Glu Ala Ile Thr Gly 
785                 790                 795                 800 


Ser Ala Ala Phe His Asp Leu Phe Asp Ser Asp Thr Thr Arg Lys Gln 
                805                 810                 815     


Val Phe Pro Asp Ala Leu Ala Ala Glu Ala Glu Gly Pro Arg Gln Ile 
            820                 825                 830         


Met Gln Arg Gly Leu Arg Glu Met Leu Arg Phe Gly Asp Met Ala Ser 
        835                 840                 845             


Phe Ala Pro Val Phe Ala Gly Arg Lys Val Thr Ala Glu Gln Val Lys 
    850                 855                 860                 


Glu Trp Gln Asn Leu Asp Ala Gln Val Ala Ala Ala His Glu Thr Arg 
865                 870                 875                 880 


Lys Lys Val His Glu Asp Tyr Lys Arg Gly Leu Arg Pro Ser Thr Glu 
                885                 890                 895     


Asn Glu Arg Leu Leu Glu Gln Lys Tyr Asp Leu Ala Ala Tyr Val Lys 
            900                 905                 910         


Ala Val Lys Thr Ile Thr Arg His Lys Arg Leu Ser His His Val Lys 
        915                 920                 925             


Leu Thr Asn His Val Arg Leu His Gln Ile Val Met Arg Val Leu Gly 
    930                 935                 940                 


Arg Leu Val Asp Tyr Ala Gly Leu Trp Glu Arg Asp Val Tyr Phe Val 
945                 950                 955                 960 


Leu Leu Ala Leu Ile Cys Leu Arg Gly Gln Thr Pro Arg Asp Val Phe 
                965                 970                 975     


Gln Asn Ala Tyr Gly Arg Lys Ala Leu Arg Gly Gly Gln Ile Arg Lys 
            980                 985                 990         


Ala Val Gln Asn Leu Glu Pro Glu  Tyr Lys Thr Ala Leu  Glu Arg His 
        995                 1000                 1005             


Phe Gly  Thr Gly Ala Phe Glu  Glu Gly Gly Val Val  Thr Ile Arg 
    1010                 1015                 1020             


Asn Asp  Leu Ala His Leu Asn  Met Met Gly Arg Ala  Ala Arg Ser 
    1025                 1030                 1035             


Asp Asp  Ala Arg Val Pro Leu  Asp Leu Thr Cys Gln  Ile Asp Arg 
    1040                 1045                 1050             


Thr Arg  Arg Leu Met Ser Tyr  Asp Arg Lys Leu Gln  Asn Ser Val 
    1055                 1060                 1065             


Ser Lys  Ser Val Thr Asp Leu  Met Glu Arg Glu Lys  Ile Arg Leu 
    1070                 1075                 1080             


Ser Phe  Arg Leu Asp Lys Gly  Lys Leu Thr Gln Ala  Thr Val Lys 
    1085                 1090                 1095             


Ala Asp  Leu Ile Lys His Phe  Lys Arg Lys Glu Leu  Thr Glu Asn 
    1100                 1105                 1110             


Leu His  Asp Pro Leu Phe Leu  Gly Met Val Ala Asp  Val Tyr Gly 
    1115                 1120                 1125             


Gly Thr  Val Gly Gln Leu Gln  Asn Asp Leu Thr Asp  Ala Gln Asp 
    1130                 1135                 1140             


Ile Ala  Ala Val Val Asn Gln  Thr Phe Ala Ala Val  Lys Ala Glu 
    1145                 1150                 1155             


Gln Asp  Ala Arg Arg Arg Pro  Arg Asn Asn Arg Ala  Gln Ser Gln 
    1160                 1165                 1170             


Asn Pro  Gly Gly Gly Thr Arg  Arg Asn Gly Gly Lys  Glu Lys Tyr 
    1175                 1180                 1185             


Gly Lys  His Pro Lys Gly Lys  Arg Thr Asp Arg His  
    1190                 1195                 1200 


<210>  791
<211>  1394
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  791

Met Arg Ile Leu Gln Ser Lys Gly Arg Ser Phe Thr Thr Phe Ser Ala 
1               5                   10                  15      


Glu Ser Ile Gly Met Thr Arg Gly Leu Glu Pro Asp Asp Thr Gln Ser 
            20                  25                  30          


Ala Ala Lys Trp Leu Asp Glu Gly Glu Lys Arg Ile Ala Pro Val Arg 
        35                  40                  45              


Ile Pro Val Phe Leu Lys Glu Asp Pro Asp Leu Ile Ile Arg Gln Val 
    50                  55                  60                  


Val Ser Val Leu Asp Lys Val Ile Arg Lys Thr Lys Ile Leu Arg Asp 
65                  70                  75                  80  


Leu Pro Leu Gln Thr Tyr Val Asp Arg Thr Leu Leu Ala Glu Glu Leu 
                85                  90                  95      


Trp Gln Arg Ile Thr Asp Arg Ile Arg Gln Ser His Asp Gly Glu Ile 
            100                 105                 110         


Thr Pro Ala Asp Leu Asp Ala Tyr Lys Ser Arg Trp Ser Trp Lys Val 
        115                 120                 125             


His Pro Tyr Ala Lys Asn Pro Pro Asp Pro Ser Asn Pro Lys Gly Asp 
    130                 135                 140                 


Gln Asn Ala Val Leu Ile Leu Lys Asn Gly Asp Arg Leu Pro Ser Pro 
145                 150                 155                 160 


Thr Asp Ser Arg Gly Arg Trp His Gly Ala Leu Trp Lys Thr Thr Ser 
                165                 170                 175     


Asp Gly Asp Pro Asp Tyr Ala Ser Thr Ala Asn Ala Ile Ile Asn His 
            180                 185                 190         


Ile Phe Ser Asn Glu Val Leu Ile Gly Gly His Tyr Leu Ser Asp Trp 
        195                 200                 205             


Ser Gly Lys Gly Ser Lys Ser Ser Val Gly Leu Ala Glu Arg Arg Gly 
    210                 215                 220                 


Asp Ser Ile Arg Ser Ser Thr Pro Asp Leu Lys Leu Pro Ile Gly Pro 
225                 230                 235                 240 


Gly Ala Ser Ala Arg Leu Leu Leu Asp Leu Asp Asp Gln Asn Ala Lys 
                245                 250                 255     


Pro Ile Ile Lys Leu Phe Phe His Gln Asp Ile Ala Ala Lys Ile Tyr 
            260                 265                 270         


Ala Phe Val Leu Glu Arg Ala Arg Val Asp Gly Pro Arg Lys Pro Asn 
        275                 280                 285             


Val Ala Phe Ser Val Arg Ser Ser Asp Phe Gly Arg Leu Leu Ser Lys 
    290                 295                 300                 


His Phe Gly Asp Val Pro Asn His Arg Asp Phe Asp Asp Glu Thr Lys 
305                 310                 315                 320 


Ile Lys Ile Val Ala Phe Tyr Asp Arg Val Lys Arg Tyr Tyr Ala Ala 
                325                 330                 335     


Leu Ser Lys Ser Glu Ser Phe Arg Arg Ala Ile Ala Lys Ala Glu Ile 
            340                 345                 350         


Ser Lys Leu Glu Ala Ile Leu Pro Arg Asp Lys Ser His Leu Leu Ala 
        355                 360                 365             


Val Leu Ala Gly Lys Glu Arg Asn Thr Glu Ile Ser Ser Leu Ile Arg 
    370                 375                 380                 


Phe Gly Lys Leu Val Gly His Ala Cys Asp Ile Ser Pro Val Val Glu 
385                 390                 395                 400 


Val Gln Thr Ala Phe Asp Asn Asn Val Arg His Leu Ala Thr Ser Asp 
                405                 410                 415     


Gly Gln Ser Glu Ile Lys Arg Asn Glu Asn Phe Thr Arg Val Trp Arg 
            420                 425                 430         


Thr Ser Val Ala Phe Ser Leu Arg Thr Leu Asp Ser Trp Leu Lys Pro 
        435                 440                 445             


Asp Trp Pro Lys Leu Thr Glu Asp Glu Ala Arg Arg Arg Asn Asp Arg 
    450                 455                 460                 


Asn Pro Gly Gly Gln Gln Ile Asn Lys Ser Ala Leu Glu Arg Asp Ile 
465                 470                 475                 480 


Ala Gln Met Arg Tyr Ile Lys Thr Ile Ala Gly Glu Glu Pro Val Glu 
                485                 490                 495     


Gly Phe Leu Asn Gly Ala Gly Ile Ile Phe Gly Ser Lys His Val Glu 
            500                 505                 510         


Phe Glu Gly Glu Ala Ala Arg Arg Cys Glu Ile Phe Ala Gln Gly Asp 
        515                 520                 525             


Lys Ala Lys Asn Arg Glu Leu Val Trp Ala Trp Leu Arg Leu Ala Ala 
    530                 535                 540                 


Glu Met Arg His Arg Thr Asn His Phe Ser Thr Lys Pro Arg Leu Val 
545                 550                 555                 560 


Ser Leu Met Gln Lys Gly Val Leu Ser Pro Thr Arg Asp Asn Pro Gly 
                565                 570                 575     


Asn Phe Glu Asn Arg Lys Gly Asn Glu Val Gln Gln Ala Ala Leu Asp 
            580                 585                 590         


Ala Phe Gly Gln Leu Leu Ser Phe Asp Ile Asn Tyr Gln Ala Ile Leu 
        595                 600                 605             


Leu Val Asn Asp Phe Asn Arg Leu Gln Val Thr Arg Tyr Thr Ser Asp 
    610                 615                 620                 


Gly Gln Phe Lys Asp Val Leu Arg Arg Ala Leu Ser Thr Asp Asp Asp 
625                 630                 635                 640 


Pro Val Ile Thr Thr Pro Lys Phe Met Ser Val Leu Arg Lys Ala Lys 
                645                 650                 655     


Gly Ile Phe Asp His Asp Leu Glu Ser Ala Pro Glu Trp Ser Lys Phe 
            660                 665                 670         


Leu Gly Ser Leu Asp Leu Thr Ala Leu Ser Ala Ala Pro Asp Gly Pro 
        675                 680                 685             


Asn Gln Phe Lys Ile Gly Leu Leu Arg His Leu Phe Ala Thr Asp Phe 
    690                 695                 700                 


Gln Ser Trp Leu Ala Arg Lys Ala Asn Thr Lys Asp Gln Ile Gln Ala 
705                 710                 715                 720 


Ala Val Val Ala Val Ser Glu Asp Lys Asn Arg Arg Thr Leu Asp Val 
                725                 730                 735     


Leu Lys Asn Glu Glu Ser Arg Val Tyr Ala Val Ala Glu Thr Ala Ala 
            740                 745                 750         


Lys Met Leu Ile Phe Ala Lys Ala Asp Ser Phe Ser Glu Leu Ala Ala 
        755                 760                 765             


Leu Val Met Ser Met Ala Phe Ala Glu Asp Asn Thr Arg Lys Ser Tyr 
    770                 775                 780                 


Lys Pro Lys Pro Glu Glu Gln Ser Lys Arg Ser Thr Trp Val Asp Asp 
785                 790                 795                 800 


Phe Gln Arg Asp Leu Phe Val Tyr Leu Phe Asn His Tyr Leu Asn Thr 
                805                 810                 815     


Gln Ser Leu His Trp Ile Phe Asp Val Thr Asp Leu Val Gly Asp Gly 
            820                 825                 830         


Glu Ala Arg Thr Val Thr Leu Phe Asp Leu Gly Ala Gly Arg Trp Ser 
        835                 840                 845             


Leu Glu Ser Lys Pro Trp His Ser Gln Phe Tyr Ala Trp Leu Tyr Leu 
    850                 855                 860                 


Thr Pro Val Asp Glu Val Ala Leu Leu Arg Asn Gln Met Arg Arg Met 
865                 870                 875                 880 


Leu Ile Leu Glu Lys Lys Gly Gly Ser Asn Glu Thr Pro Ala Leu Arg 
                885                 890                 895     


Asp Leu Asp Arg Leu Met Thr Leu Tyr Ile Ala Val Ser Ser Ala Gly 
            900                 905                 910         


Phe Asp Gly Thr Glu His Ile Gln Thr Thr Ala Glu Asp Asp Lys Arg 
        915                 920                 925             


Phe Arg Leu Tyr Gly Gly Leu Leu Tyr Glu Asp Ala Val Gln Phe Glu 
    930                 935                 940                 


Lys Val Tyr Ser Ala Ala Ala Asp Thr Asn Asp Gln Ser Leu Pro Gly 
945                 950                 955                 960 


Thr Arg Arg Gly Leu Arg Gln Ile Ala Arg Leu Gly His Ile Ser Val 
                965                 970                 975     


Leu Lys Gly Ile Phe Glu Lys His Leu Ile Thr Pro Asp Glu Val Ser 
            980                 985                 990         


Thr Leu Ile Glu Thr Lys Lys Ala  Lys Ser Phe Lys Asp  Ala Thr Lys 
        995                 1000                 1005             


Arg Ala  Lys Leu His Asn Glu  Ile Val Thr Leu Ser  Lys Gly Phe 
    1010                 1015                 1020             


Lys Pro  Asp Ile His Gln Leu  Asp Lys Lys Cys Lys  Glu Tyr Lys 
    1025                 1030                 1035             


Asp Leu  Ser Ala Glu Ile Thr  Val His Asn Phe Lys  Ala Ala Gly 
    1040                 1045                 1050             


Ala Arg  Leu Thr Glu His Ala  Arg Leu His Gln Leu  Leu Met Arg 
    1055                 1060                 1065             


Val Ile  Ser Arg Leu Ala Asp  Phe Thr Leu Ile Trp  Glu Arg Asp 
    1070                 1075                 1080             


Arg Asn  Tyr Val Leu Leu Ala  Leu Ile Tyr Pro Lys  Leu Leu His 
    1085                 1090                 1095             


Pro Asp  Glu Asn Ala Pro Arg  Leu His Arg Arg Asp  Gly Lys Val 
    1100                 1105                 1110             


Gly Phe  Leu Leu Pro Pro Glu  Thr Thr Lys Thr Met  Arg Ala Ala 
    1115                 1120                 1125             


His Ala  Pro Leu Ser Asp Asn  Asp Lys Arg Lys Leu  Ser Arg Glu 
    1130                 1135                 1140             


Ile Ala  Leu Thr Ser Glu Asn  Val Glu Glu Gly Phe  Leu Pro Leu 
    1145                 1150                 1155             


Trp Asp  Asp Asp Met Gly Tyr  Arg Leu Thr Gly Tyr  Pro Ile His 
    1160                 1165                 1170             


Leu Ala  Leu Leu Glu Met Asp  Lys Arg Asp Ala Phe  Ala Arg Phe 
    1175                 1180                 1185             


Phe Asp  Arg Ser Glu Thr Glu  Asn Pro Leu Asp Val  Ala Glu Arg 
    1190                 1195                 1200             


Ala Arg  Ile Lys Arg Gly Thr  Gly Asn Ser Ser Pro  Leu Gln Arg 
    1205                 1210                 1215             


Arg Gln  Leu Thr Phe Lys Asp  Gly Lys Arg Arg Ile  Arg Asn Asp 
    1220                 1225                 1230             


Phe Ala  His Phe Asn Val Ile  Val Ser Asp Arg Lys  Arg Val Ser 
    1235                 1240                 1245             


Leu Thr  Tyr Leu Met Asn Ala  Val Arg Ser Leu Val  Ala Tyr Asp 
    1250                 1255                 1260             


Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ala Val Ala  Asp Ile Leu 
    1265                 1270                 1275             


Val Asp  Glu Gly Leu Asp Ile  Ser Trp Glu Met Thr  Gly Asp Arg 
    1280                 1285                 1290             


Leu Arg  Asn Pro Val Val Val  Pro Arg Leu Glu Thr  Asn Leu Lys 
    1295                 1300                 1305             


Lys Val  Arg Lys His Arg Gly  Leu Ala Asp Pro Gln  Phe Val Leu 
    1310                 1315                 1320             


Pro Leu  Ala Ser Val Arg Tyr  Thr Ser Met Val Lys  Ala Leu Phe 
    1325                 1330                 1335             


Asp Phe  Gln Ala Gly Gly Tyr  Arg Lys Glu Ile Ile  Val Gly Gln 
    1340                 1345                 1350             


Glu Thr  Lys Gln Arg Gly Glu  Leu Gly Tyr Pro Val  Glu Leu Arg 
    1355                 1360                 1365             


Val Leu  Leu Gly Ser Leu Gly  Ala Asp Met Pro Asp  Asp Val Leu 
    1370                 1375                 1380             


Gly Met  Lys Leu Tyr Val Ile  Gln Pro Gln Lys 
    1385                 1390                 


<210>  792
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  792

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Pro Gly Thr Asp Thr 
            20                  25                  30          


Ile Asp Leu Lys Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Lys Val Phe Asn Gln Ile Gln Val Gly Asn Lys Pro Lys Lys 
    50                  55                  60                  


Trp Lys Lys Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Glu Tyr Val Glu Ser Ser Gln Arg Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Asp Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Glu Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Gly Leu Phe Val Asn Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Ile Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Ser Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Tyr Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Lys Asp Arg Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Lys Glu Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Gln Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Phe 
            660                 665                 670         


Ile Arg Lys Asn Phe Pro Glu Asp Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Lys Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Tyr 
                805                 810                 815     


Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Thr 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Asp Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Asp Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asn  Ser Glu Lys Lys Glu  Ala Tyr Gln Lys Ile  Glu Val Asn 
    1100                 1105                 1110             


Gly Asp  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Val  Tyr Ala Pro Asp Glu  Lys Gly Asp 
    1130                 1135                 1140             


Ile Leu  Lys Glu Gln Cys Thr  Lys Gly Gly Ala Gly  Gly Lys Ile 
    1145                 1150                 1155             


Ser Ala  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Lys Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Lys Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Lys Gln 
    1250                 1255                 1260             


Thr Thr  Ser Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Ser Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Lys  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Val Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Gly Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Pro Asn 
    1370                 1375                 1380         


<210>  793
<211>  1385
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  793

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Pro Gly Thr Asp Thr 
            20                  25                  30          


Ile Asp Leu Asn Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Thr Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Asp Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Glu Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Gly Leu Phe Val Asn Ile 
                325                 330                 335     


Pro Asp Val Leu Met Lys Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Ile Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Ser Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg 
465                 470                 475                 480 


Asn Gly Ile Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Tyr Glu Asn 
                485                 490                 495     


Leu Gln Arg Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu 
            500                 505                 510         


Ala Arg Ala Val Cys Asp Met Ser Asn Leu Lys Asp Arg Glu Ser Asp 
        515                 520                 525             


Phe Leu Leu Trp Lys Lys Glu Asp Ile Ala Asp Lys Leu Lys Asn Lys 
    530                 535                 540                 


Asp Asp Met Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys 
545                 550                 555                 560 


Ser Ser Trp Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn 
                565                 570                 575     


Lys Tyr Asn Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile 
            580                 585                 590         


Tyr Cys Ala Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn 
        595                 600                 605             


Asn Glu Lys Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu 
    610                 615                 620                 


Thr Glu Phe Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn 
625                 630                 635                 640 


Leu Tyr Met Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Gln 
                645                 650                 655     


Leu Tyr Ser Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn 
            660                 665                 670         


Ser Val Phe Ile Arg Lys Asn Phe Pro Glu Asp Ile Thr Asn Val Leu 
        675                 680                 685             


Arg Tyr Gln Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr 
    690                 695                 700                 


Ser Ala Cys Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu 
705                 710                 715                 720 


Gln Ser Asp Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu 
                725                 730                 735     


Ser Trp Asp Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn 
            740                 745                 750         


His Phe Ser Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys 
        755                 760                 765             


Gln Ile Tyr Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys 
    770                 775                 780                 


Val Arg Ser Ser Asn Asp Ser Ile Phe Asp Lys Pro Ile Tyr His His 
785                 790                 795                 800 


Tyr Lys Val Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr 
                805                 810                 815     


Leu Lys Tyr Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys 
            820                 825                 830         


Ala Asn Glu Ile Arg Lys Ile Asp Lys Glu Arg Phe Leu Pro Asp Trp 
        835                 840                 845             


Thr Ser Thr Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln 
    850                 855                 860                 


Glu Leu Gln Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser 
865                 870                 875                 880 


Leu Asn Leu Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr 
                885                 890                 895     


Asp Ile Lys Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser 
            900                 905                 910         


Val Gln Asp Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val 
        915                 920                 925             


Cys Ser Leu Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe 
    930                 935                 940                 


Asn Asp Lys Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe 
945                 950                 955                 960 


Ser Asn Ala Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser 
                965                 970                 975     


Asn Glu Glu Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val 
            980                 985                 990         


Asn Arg Asn Ile Val His Ser Lys  Leu Phe Ala Ala Asp  His Ile Leu 
        995                 1000                 1005             


Arg Asp  Ile Val Glu Pro Val  Ser Lys Asp Asn Ile  Glu Glu Phe 
    1010                 1015                 1020             


Tyr Asp  Gln Lys Ala Glu Ile  Val Tyr Cys Lys Ile  Lys Gly Lys 
    1025                 1030                 1035             


Asp Ile  Thr Ala Glu Glu Gln  Lys Ala Val Leu Lys  Tyr Gln Lys 
    1040                 1045                 1050             


Leu Lys  Asn Arg Val Glu Leu  Arg Asp Ile Val Glu  Tyr Gly Glu 
    1055                 1060                 1065             


Ile Ile  Asn Glu Leu Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met 
    1070                 1075                 1080             


Arg Glu  Arg Asp Leu Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn 
    1085                 1090                 1095             


Cys Leu  Arg Asn Asn Ser Glu  Lys Lys Glu Ala Tyr  Gln Lys Ile 
    1100                 1105                 1110             


Glu Val  Asn Gly Asp Ser Ile  Lys Asp Ala Ile Leu  Tyr Gln Ile 
    1115                 1120                 1125             


Ile Gly  Met Tyr Val Asn Gly  Val Ala Val Tyr Ala  Pro Asp Glu 
    1130                 1135                 1140             


Lys Gly  Asp Ile Leu Lys Glu  Gln Cys Thr Lys Gly  Gly Ala Gly 
    1145                 1150                 1155             


Gly Lys  Ile Ser Ala Phe Asn  Arg Tyr Ser Glu Tyr  Leu Gly Leu 
    1160                 1165                 1170             


Asp Lys  Leu Thr Leu Tyr Asn  Ala Gly Leu Glu Ile  Phe Glu Val 
    1175                 1180                 1185             


Val Ala  Glu His Asp Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp 
    1190                 1195                 1200             


His Phe  Lys Tyr Tyr Leu Gly  Asp Tyr Arg Ser Met  Leu Ser Ile 
    1205                 1210                 1215             


Tyr Ser  Glu Val Phe Asp Arg  Phe Phe Thr Tyr Asp  Ile Lys Tyr 
    1220                 1225                 1230             


Gln Lys  Asn Val Leu Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His 
    1235                 1240                 1245             


Asn Val  Ile Val Glu Pro Val  Leu Glu Ser Gly Phe  Lys Thr Ile 
    1250                 1255                 1260             


Gly Lys  Gln Thr Thr Ser Gly  Ala Lys Leu Ser Ile  Arg Ser Ile 
    1265                 1270                 1275             


Lys Ser  Asp Thr Phe Gln Tyr  Lys Val Lys Gly Gly  Ser Leu Ile 
    1280                 1285                 1290             


Thr Asp  Ala Lys Asp Glu Arg  Tyr Leu Lys Thr Ile  Arg Lys Ile 
    1295                 1300                 1305             


Leu Tyr  Tyr Val Glu Asn Glu  Glu Asp Asn Leu Lys  Lys Ser Val 
    1310                 1315                 1320             


Val Val  Thr Asn Ala Asp Lys  Tyr Glu Lys Asn Lys  Glu Ser Asp 
    1325                 1330                 1335             


Asp Gln  Asn Lys Gln Lys Glu  Lys Lys Asn Lys Asp  Asn Lys Gly 
    1340                 1345                 1350             


Lys Lys  Asn Glu Glu Thr Lys  Ser Asp Ala Gly Lys  Asn Asn Asn 
    1355                 1360                 1365             


Glu Arg  Leu Ser Tyr Asn Pro  Phe Ala Asn Leu Asn  Phe Lys Leu 
    1370                 1375                 1380             


Pro Asn  
    1385 


<210>  794
<211>  1373
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  794

Met Ala Lys His Leu Arg Pro Ile Gly Glu Ser Tyr Thr Asp Phe Leu 
1               5                   10                  15      


Asp Glu Thr Glu Phe Val Arg Leu Gly Arg Gly Leu His Arg Gly His 
            20                  25                  30          


His Gly Val Gln Ile Pro Pro Thr Glu Leu Pro Ser Tyr Leu Ala Glu 
        35                  40                  45              


Tyr Arg Lys Ala Leu Met Arg Gln Val Val Ala Val Leu Asp Lys Val 
    50                  55                  60                  


Val Gly Lys Arg Arg Arg Leu Ser Gly Met His Pro Glu Ala Tyr Arg 
65                  70                  75                  80  


Asp Arg Val His Leu Ala Glu Ala Leu Trp Val Arg Leu Val Ala Arg 
                85                  90                  95      


Val Lys Glu Ile Gly Thr Pro Pro Asp Pro Ser Glu Leu Leu Asp Leu 
            100                 105                 110         


Arg Arg Met Trp Asn Ala Lys Ala His Pro Tyr Ala Glu Tyr Asp Val 
        115                 120                 125             


Val Pro Arg Ala Pro Leu Asn Asp Gly Asn Gly Gln Lys Ile Leu Glu 
    130                 135                 140                 


Cys Arg Glu Val Asp Asp Pro Lys Ile Glu Arg Ser Asp Phe Glu Gly 
145                 150                 155                 160 


Arg Trp His Gly Arg Phe Trp Gln Ser Glu Pro Gly Pro Val Asp Tyr 
                165                 170                 175     


Asn Ala Ile Ala Asp Arg Ile Phe Ala His Leu Phe Asp Gln Glu Ala 
            180                 185                 190         


Val Ile Gly Gly Gly Pro Arg Arg Glu Gly Asn Val Thr Val Pro Asp 
        195                 200                 205             


Glu Asp Ile Asn Gly Gln Pro Gly Pro Ala Thr Gly Lys Gly Leu Ile 
    210                 215                 220                 


Ile Ala Arg Gly Gln Ser Ile Val Lys Ser Ala Ser Asp Pro Arg Arg 
225                 230                 235                 240 


Ser Ser Lys Lys Val Gln Arg Thr Trp Asp Lys Ala Val Glu Arg Arg 
                245                 250                 255     


Tyr Phe Gly Asp Asp Gly Lys Gly Gly Ser Asp Ile Ala Lys Ala Ile 
            260                 265                 270         


Tyr Glu Glu Leu Gly Asp Pro Ala Thr Leu Ala Asp Pro Ile Tyr Ala 
        275                 280                 285             


Ser Trp Phe Gly Ser Arg Leu Tyr Asp His Phe Gly Ser Phe Lys Asn 
    290                 295                 300                 


Ser Leu Pro Leu Glu Leu Lys Asp Pro Phe Lys Glu Gln Ile Trp Ala 
305                 310                 315                 320 


Leu His Asn Ser Val Arg Gln Phe Tyr Gln Arg Met Ala Lys Ser Asp 
                325                 330                 335     


Arg Phe Arg Leu Ala Leu Gln Asn Ala Arg Ser Glu Val Pro Asp Arg 
            340                 345                 350         


Ser Glu Leu Leu Ala Leu Leu Pro Lys Asp His Asp His Leu Leu Leu 
        355                 360                 365             


Val Leu Gly Gly Lys Lys Lys Asn Ala Glu Met Ser Glu Leu Ile Arg 
    370                 375                 380                 


Leu Gly Lys Leu Phe Val His Ala Ser Asp Val Leu His Asp Phe Asp 
385                 390                 395                 400 


Ala Asn Asp Ala Ala Ala Leu Asp Ala Phe Lys Arg Arg Met Ser Phe 
                405                 410                 415     


Leu Ala Thr Ser Ile Gly Gln Ser Glu Ile Lys Gln Thr Glu Thr Phe 
            420                 425                 430         


Ala Arg Thr Trp Arg Gly Ala Val Gly Leu Thr Leu Arg Thr Val Lys 
        435                 440                 445             


Gly Leu Ala Asp Pro Arg Gly Ile Ile Gly Thr Pro Asp Asn Arg Asp 
    450                 455                 460                 


Leu Gly Thr Ala Gly Pro Met Lys Asp Ala Phe Asn Lys Phe Asp Gln 
465                 470                 475                 480 


Pro His Phe Gln Gln His Met Thr Ile Ile Phe Gly Asn Lys Glu Leu 
                485                 490                 495     


Gln Ala Glu Gly Asn Pro Thr Arg Ser Ser Val Phe Thr Ala Asn Gly 
            500                 505                 510         


Asp Lys Asp His Gln Ala Glu Leu Leu Trp Gly Phe Leu Cys Val Val 
        515                 520                 525             


Arg Ser Val Arg Asn Arg Thr Asn His Tyr Asn Val Arg Arg Ala Leu 
    530                 535                 540                 


Leu Arg Leu Leu Asp Glu Gly Ile Val Ser Pro Met Pro Ser Asp Pro 
545                 550                 555                 560 


Lys Lys Glu Arg Val Glu Asn Arg Asn Leu Cys Thr Val Ser Pro Thr 
                565                 570                 575     


Ala Leu Glu Ala Phe Arg Arg Leu Leu Asn Phe Asp Leu Ala Ile Gln 
            580                 585                 590         


Lys Glu Ala Val Arg Thr Ala Leu Glu Gln Ala Lys Ala Ser Glu Phe 
        595                 600                 605             


Val Glu Glu Gly Lys Leu Arg Gly Leu Val Ser Glu Leu Ala Gly Thr 
    610                 615                 620                 


Glu Asp Met Pro Ala Leu His Ile Pro Arg Phe Ser Ala Val Met Asp 
625                 630                 635                 640 


Lys Val Arg Arg Leu Ala Asp Asn Arg Asp Val Gly Leu Asp Pro Ile 
                645                 650                 655     


Leu Ser Thr Leu Gln Arg Ser Leu Pro Pro Thr Asp Lys Gln Ala Glu 
            660                 665                 670         


Ser Asp Ala Ala Arg Cys Arg Tyr Arg Leu Leu Leu Glu Leu Tyr Lys 
        675                 680                 685             


Ser Gly Phe Arg Ser Trp Phe Ser Gly Ile Gln Ser Asn Glu Glu Asn 
    690                 695                 700                 


Asn Arg Glu Ile Cys His Trp Ala Val Lys Gln Val Gly Arg Ala Lys 
705                 710                 715                 720 


Asp Ala Arg Lys Ser Glu Tyr Asp Lys Lys Thr Lys Arg His Tyr Arg 
                725                 730                 735     


Ser Pro Asn Ser Leu Ile Asp Asp Leu Gly Leu Asp Lys Phe Asp Asp 
            740                 745                 750         


Leu Thr Asp Leu Leu Glu Ala Leu Ala Ser Gln Ser Thr Arg Glu His 
        755                 760                 765             


Asp Gln Asn Leu Lys Tyr Val Pro Asp Ala Arg Val Gln Ser Gln Met 
    770                 775                 780                 


Ser Asn Arg Ile Glu Glu Phe Arg Gln Glu Leu Phe Ala His Ile Phe 
785                 790                 795                 800 


Thr Lys Tyr Leu Asp Thr His Asp Phe Gly Trp Ile Gly Ala Ile Glu 
                805                 810                 815     


Val Arg Arg Glu Ala Cys Asp Leu Ala Asp Val Val Ser Ala Phe Glu 
            820                 825                 830         


Val Arg Asp Gln Lys Phe Asp Ala Asp Trp His Ser Gln Phe Tyr Ala 
        835                 840                 845             


Trp Leu Tyr Met Val Pro Pro Ile Glu Ala Ser Arg Leu Arg His Gln 
    850                 855                 860                 


Met Arg Lys Ser Ala Val Met Asp Asp Lys Trp Ser Thr Thr Leu Glu 
865                 870                 875                 880 


Leu Thr Ser Gly Asp Arg Lys Thr Arg Asp Asp His Ala Gln Asp Val 
                885                 890                 895     


Leu Ala Asp Met Asp Arg Leu Phe Ser Leu Tyr Thr Lys Val Gln Ala 
            900                 905                 910         


Ala Gly Phe Asn Gly Gln Glu His Glu Ser Ala Leu Gly Ser Lys Ser 
        915                 920                 925             


Leu Phe Tyr Glu Asp Gly Asn Gln Phe Asp Glu Val Tyr Ser Pro Asp 
    930                 935                 940                 


Thr Glu Thr His Asn Lys Thr Phe Pro Gly Thr Arg Arg Gly Leu Arg 
945                 950                 955                 960 


Gln Leu Val Arg Tyr Ala His Leu Pro Ala Leu Glu Gly Val Phe Lys 
                965                 970                 975     


Lys His Arg Ile Thr Lys Ala Glu Val Glu Thr Phe Val Ala Leu Tyr 
            980                 985                 990         


Asp Glu Asn Arg Arg Asp Pro Gly  Ser Val Ala His Met  Leu Arg Arg 
        995                 1000                 1005             


Glu Lys  Leu Arg Thr Glu Ile  Leu Arg Ser Ile His  Asp Gly Pro 
    1010                 1015                 1020             


Lys Pro  Lys Asp Lys Asp Phe  Trp Pro Lys Leu Glu  Ala Lys Cys 
    1025                 1030                 1035             


Leu Glu  Tyr Arg Thr Val Ala  Thr Glu Thr Ala Ile  Tyr Asn Phe 
    1040                 1045                 1050             


Gln Ala  Asn Ala Ala Arg Leu  Asn Asp His Ala Arg  Leu His Gln 
    1055                 1060                 1065             


Ile Val  Met Arg Val Val Ala  Arg Leu Thr Asp Tyr  Ala Leu Ile 
    1070                 1075                 1080             


Trp Glu  Arg Asp Arg Leu Phe  Ala Phe Val Gly Met  Leu Tyr Arg 
    1085                 1090                 1095             


Gln Thr  Gly Gly Thr Gly Ile  Asn Pro Ala Met Arg  His Ala Glu 
    1100                 1105                 1110             


Lys Thr  Asn Ala Pro Pro Arg  Ile Gly Ile Leu Val  Ser Asp Ser 
    1115                 1120                 1125             


Ala Leu  Ala Lys Lys Leu Asn  Ser Asn Ser Ala Glu  Val Phe Ile 
    1130                 1135                 1140             


Pro Tyr  Leu Asp Thr Glu Thr  Gly Phe Asp Ala Pro  Arg Phe Asp 
    1145                 1150                 1155             


Asp Leu  Cys Thr Leu Leu Ser  His Glu His Ala Lys  Glu Phe Arg 
    1160                 1165                 1170             


Phe His  Phe Leu Glu Val Gly  Glu Glu Asn Ser Lys  Asp Glu Ala 
    1175                 1180                 1185             


Arg Arg  Leu Asn Glu Glu Thr  Met Gly His Arg Lys  Arg Pro Ala 
    1190                 1195                 1200             


Phe Lys  Arg Gly Thr Arg Arg  Gln Gly Ile Arg Asn  Asp Leu Ala 
    1205                 1210                 1215             


His His  Asn Val Leu Asp Leu  Ala Gly Gly Ala Gly  Pro Asn Leu 
    1220                 1225                 1230             


Thr Tyr  Val Val Asn Ala Val  Arg Ser Leu Leu Ser  Tyr Asp Arg 
    1235                 1240                 1245             


Lys Leu  Lys Asn Ala Val Pro  Lys Ser Ile Lys Arg  Ile Leu Gly 
    1250                 1255                 1260             


Glu Glu  Gly Leu Ile Ile Glu  Trp Gln Met Asn Tyr  Asp Arg Leu 
    1265                 1270                 1275             


Lys Lys  Pro Thr Val Tyr Pro  Asn Val Glu Thr His  Leu Thr Met 
    1280                 1285                 1290             


Val Pro  Pro Arg His Met Thr  Ala Pro Val Ser Phe  Thr Leu Pro 
    1295                 1300                 1305             


Arg Ala  Ser Val Arg Leu Ala  Ser Met Val Lys Ala  Val Phe Asp 
    1310                 1315                 1320             


Phe Gly  Ser Ser Gly Tyr Gly  Glu Glu Arg Met Ile  Gly Gly Arg 
    1325                 1330                 1335             


Thr Ala  Lys Gln Ala Val Tyr  Pro Asp Asp Phe Thr  Arg Arg Phe 
    1340                 1345                 1350             


Pro Gln  Thr Pro Met Gly Leu  Lys Gln Ala Thr Arg  Leu Val Phe 
    1355                 1360                 1365             


Ala Ser  Glu Asn Ser 
    1370             


<210>  795
<211>  1287
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  795

Met Arg Ile Gly Lys Val Gln Gly Arg Thr Phe Thr Gly Phe Asp Asn 
1               5                   10                  15      


Ala Arg Gly Lys Thr Leu Arg Arg Arg Leu Leu Thr Arg Pro Asp Asn 
            20                  25                  30          


Glu Ala Arg Ser Leu Ser Glu His Leu Ala His Asp Pro Lys Ala Leu 
        35                  40                  45              


Ile Gly Gln Ala Ile Ser Arg Ile Asp Thr Ile Tyr Gln Lys Pro Lys 
    50                  55                  60                  


Thr Gly Lys Pro Thr Pro Glu Gln Phe Gly His Arg Asp Thr Leu Gly 
65                  70                  75                  80  


Trp Ala Tyr Trp Lys Leu Leu Val Ala Ser Tyr Pro Glu Val Glu Gly 
                85                  90                  95      


His Arg Asp Leu Phe Val Arg Arg Leu His Pro Tyr Gly Asp Thr Pro 
            100                 105                 110         


Pro Lys Ser His Gly Gln Lys Glu Gly Glu His Gln Lys Gly Gly Lys 
        115                 120                 125             


Pro Gln Leu Glu Gly Arg Trp His Gly Val Met Ala Gln His Gly Lys 
    130                 135                 140                 


Asn Pro Asp Gln Ile Ala Ala Arg Leu Phe Asp His Leu His Asn Ser 
145                 150                 155                 160 


Glu Leu Arg Phe Gly Gly Thr Ala Ser Gly Glu Pro Arg Thr Arg Pro 
                165                 170                 175     


Gly Lys Glu Ala Thr Pro Thr Gly Leu Ile Gly Ala Arg Ala Lys Thr 
            180                 185                 190         


Ile Glu His Ser Val Leu Pro Arg Asp Ala Lys Arg Phe Val Ala Glu 
        195                 200                 205             


Trp Arg Gly Glu Asp Gln Glu Arg Tyr Ala Gly Ala Arg Asp Ile Ala 
    210                 215                 220                 


Ala Ala Ile Ser Ala Gly Leu Asn Asp Lys Asp Gln Lys Ser Gly Ser 
225                 230                 235                 240 


Gly Arg Lys Ser Ala Val Ile Gly Lys Leu Leu Ser Asp His Leu Glu 
                245                 250                 255     


Thr Leu Thr Gly Asn Arg Lys Cys Arg Phe Asp Pro Lys Ser Thr Ala 
            260                 265                 270         


Glu Thr Leu Glu Leu Arg Asp Gly Glu Ser Val Asp Asp Arg Arg Arg 
        275                 280                 285             


Ile Leu Glu Leu His Ala Glu Val Lys Ala Thr Tyr Lys Arg Met Ala 
    290                 295                 300                 


Ala Trp Lys Pro Ala Lys Leu Pro Arg Asn Ser Asp Glu Leu Phe Arg 
305                 310                 315                 320 


Leu Val Arg Gln Gln Ala Asp Asn Arg Ile Leu Asn His Leu Val Arg 
                325                 330                 335     


Val Gly Arg Ile Ser Val Tyr Ser Glu Gln Ser Asp Ala Leu Ser Glu 
            340                 345                 350         


Ser Gln Phe Trp Thr Ser Gly Gly Gln Thr Gln Ile Lys Glu Ser Glu 
        355                 360                 365             


Val Phe Ala Arg Leu Trp Ile Gly Ala Ile Ser Arg Ala Ser Tyr Ser 
    370                 375                 380                 


Met Lys Ala Trp Leu Glu Pro Glu Gly Thr Val Phe Asn Pro Ser Ile 
385                 390                 395                 400 


Asn Asp Phe Asp Val Thr Ser Ser His Asn Thr Asn Arg Ile Leu Glu 
                405                 410                 415     


Asp Ser Gly Arg Leu Ser Asn Ala Met Ala Arg Arg Ala Ile Tyr Phe 
            420                 425                 430         


Gly Glu Thr Pro Glu Phe Asp Ala Leu Gly Glu Glu Asp Gln Arg Val 
        435                 440                 445             


Leu Val Lys Lys Cys Leu Asp Ala Leu Ser Ala Cys Arg Asn Arg Thr 
    450                 455                 460                 


Phe His His Gly Gln Arg Ala Lys Phe Leu Lys Glu Val Arg Lys Gly 
465                 470                 475                 480 


Leu Lys Glu Lys Glu Ala Asp Ser Ala Gly Pro Ala Ala Trp Glu Gly 
                485                 490                 495     


Ile Arg Glu Val Ile Gln Ala Asp Ala Arg Asn Leu Gly Ala Arg Leu 
            500                 505                 510         


Leu Gln Asp Leu Thr Gly Ala Lys Val His Ser Phe Ala Thr Asp Pro 
        515                 520                 525             


Glu Phe Arg His Leu Tyr Glu Ser Val Ala Ala Thr Leu Thr Ala Gly 
    530                 535                 540                 


Gly Glu Leu Glu Ala Ala Leu Pro Arg Leu Lys Asn Val Leu Lys Arg 
545                 550                 555                 560 


Ala Glu Gly Val Arg Cys Tyr Leu Asp Thr Pro Ser Gln Arg Arg Glu 
                565                 570                 575     


Gly Asp Glu Ser Leu Ile Ala Arg Leu Pro Val Ala Pro Val Pro Arg 
            580                 585                 590         


Glu Leu Asp Asp Ala Ala Thr Lys Ala Arg His Ser Ala Leu Leu Arg 
        595                 600                 605             


Leu Tyr Asp Gly Pro Phe Arg Pro Trp Ala Thr Glu Leu Arg Gly Glu 
    610                 615                 620                 


Arg Leu Ser Asp Tyr Ala Ala Arg Ala Lys Arg Leu Ala Thr Arg Leu 
625                 630                 635                 640 


Ala Lys Ser Thr Asn Thr Ala Ser Pro Tyr Pro Asp Ser Val Glu Gly 
                645                 650                 655     


Arg Ser Val Arg Leu Arg Asp Pro Ile Thr Ala Asp Thr Ala Pro Glu 
            660                 665                 670         


Thr Leu Lys Thr Tyr Leu Ser Ala Leu Thr Ala Glu Thr Ala Thr Glu 
        675                 680                 685             


Phe Arg Val Gln Lys Gly Tyr Glu Ser Asp Gly Glu Lys Ala Lys Glu 
    690                 695                 700                 


Gln Ala Glu Phe Ile Glu Asp Phe Arg Arg Asp Met Ile Ala Leu Ala 
705                 710                 715                 720 


Phe Gln Asp Phe Ile Arg Asp His Gly Phe Ala Trp Leu Leu Asp Ile 
                725                 730                 735     


Ala Ser Lys Ala Glu Pro Ser Asn Asp Ala Pro Asn Leu Pro Asp Pro 
            740                 745                 750         


Val Asp Thr Gly Lys Asp Thr Val Phe Glu Asp Trp Gln Ala Leu Leu 
        755                 760                 765             


Tyr Leu Phe Leu His Phe Val Pro Ala Asp Asp Val Ser Gln Leu Leu 
    770                 775                 780                 


His Gln Leu Arg Lys Trp Asp Ala Leu Gln Asp Lys Tyr Glu Leu Ala 
785                 790                 795                 800 


Glu Pro Gly Glu Thr Leu Gly Gln Thr Lys Ala Asp Thr Arg Lys Ile 
                805                 810                 815     


Val Gly Gln Phe Arg Asp Cys Leu Thr Leu Phe Leu Lys Thr Gly Asp 
            820                 825                 830         


Ala Arg Phe Asp Gly Glu Gly Val Glu Leu Pro Leu Ser Asp Phe Gln 
        835                 840                 845             


Glu Leu Phe Glu Ser Pro Ala Thr Phe Lys Glu Leu Phe Leu Ala Glu 
    850                 855                 860                 


Pro Ala Glu Asn Asp Ala Ser Glu Thr Asp Asp Gln Asp Ala Pro Gly 
865                 870                 875                 880 


Glu Lys His Arg Val Thr Arg Thr Arg Arg Gly Leu Arg Gln Ile Leu 
                885                 890                 895     


Arg Tyr Asn His Met Pro Val Leu Arg Asp Leu Phe Leu Ala His Lys 
            900                 905                 910         


Val Thr Asp Ala Glu Val Asp Gly Leu Gln Ala Leu Glu Val Asp Asp 
        915                 920                 925             


Pro Gln Thr Gly Glu Ser Gln Ile Gly Ala Ala Gln Arg Ile Arg Thr 
    930                 935                 940                 


Glu Ile His His His Thr Ser Asn Asp Lys Gln Ile Ser Glu Ala Lys 
945                 950                 955                 960 


Val Glu Glu Tyr Arg Arg Ala Leu Ser Thr Ile Glu Arg His Arg Phe 
                965                 970                 975     


Leu Val Gly Arg Val Tyr Leu Gly Asp His Ile Arg Val His Lys Leu 
            980                 985                 990         


Met Met Asp Val Met Gly Arg Leu  Val Asp Phe Ala Gly  Ala Trp Glu 
        995                 1000                 1005             


Arg Glu  Ala Ala Asp Gly Asp  Arg Lys Gly Phe Ile  Ser Arg Ala 
    1010                 1015                 1020             


Ile Ala  Leu Pro Glu Val Ala  Glu Gly Tyr Ala Ala  Asp Arg Leu 
    1025                 1030                 1035             


Lys Thr  Val Ala Arg Arg Val  Leu Asp Asp Gly Glu  Ala Arg Arg 
    1040                 1045                 1050             


Ile Arg  Asn Asp Leu Gly His  Phe Asn Asp Leu Ala  Pro Thr Ser 
    1055                 1060                 1065             


Gly Pro  Ala Asn Leu Thr Phe  Val Val Asn Arg Ala  Arg Arg Met 
    1070                 1075                 1080             


Met Arg  His Asp Arg Lys Arg  Lys Asn Ala Val Thr  Lys Ser Val 
    1085                 1090                 1095             


Ile Glu  Ile Leu Asn Arg Gln  Gly Leu Gly Ile Glu  Trp Thr Met 
    1100                 1105                 1110             


Arg Asn  His Glu Leu Cys Glu  Ala Lys Leu Trp Gln  Asn Pro Val 
    1115                 1120                 1125             


Lys His  Leu Gly Phe Ala Thr  Leu Glu Gly Arg Gly  Lys Lys Trp 
    1130                 1135                 1140             


Arg Arg  Pro Phe Glu Ala Arg  Tyr Gly Asp Ala Tyr  Met Ala Met 
    1145                 1150                 1155             


Val Ala  Gln Leu Phe Asp Gly  Thr Val Thr Ser Pro  Pro Ala Lys 
    1160                 1165                 1170             


Gly Pro  Pro Gln Ser Gly Lys  Ser Gly Gly Lys Pro  Gly Lys Gly 
    1175                 1180                 1185             


Ala Glu  Gly Gly Ala Lys Glu  Lys Ser Arg Ser Pro  Thr Arg Met 
    1190                 1195                 1200             


Glu Glu  Gly Gly Val Tyr Glu  Gly Arg Val Ala Lys  Ala Lys Ser 
    1205                 1210                 1215             


Asp Lys  Gly Phe Gly Phe Leu  Leu Val Glu Gly Ala  Gln Glu Glu 
    1220                 1225                 1230             


Ile Phe  Leu His Ile Tyr Gly  Ile Ser Gly Asn Arg  Pro Ala Arg 
    1235                 1240                 1245             


Ile Glu  Asn Gly Gln Arg Tyr  Arg Phe Thr Leu Gly  Ile Asp Arg 
    1250                 1255                 1260             


Asp Arg  Glu Arg Arg Lys Glu  Arg Ala Trp Val Ala  Arg Glu Ala 
    1265                 1270                 1275             


Val Arg  Ile Asp Glu Asn Arg  Ser Lys 
    1280                 1285         


<210>  796
<211>  1287
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  796

Met Arg Ile Gly Lys Val Gln Gly Arg Thr Phe Thr Gly Phe Asp Asn 
1               5                   10                  15      


Ala Arg Gly Lys Thr Leu Arg Arg Arg Leu Leu Thr Arg Pro Asp Asn 
            20                  25                  30          


Glu Ala Arg Ser Leu Ser Glu His Leu Ala His Asp Pro Lys Ala Leu 
        35                  40                  45              


Ile Gly Gln Ala Ile Ser Arg Ile Asp Thr Ile Tyr Gln Lys Pro Lys 
    50                  55                  60                  


Thr Gly Lys Pro Thr Pro Glu Gln Phe Gly His Arg Asp Thr Leu Gly 
65                  70                  75                  80  


Trp Ala Tyr Trp Lys Leu Leu Val Ala Ser Tyr Pro Glu Val Glu Gly 
                85                  90                  95      


His Arg Asp Leu Phe Val Arg Arg Leu His Pro Tyr Gly Asp Thr Pro 
            100                 105                 110         


Pro Lys Ser His Gly Gln Lys Glu Gly Glu His Gln Lys Gly Gly Lys 
        115                 120                 125             


Pro Gln Leu Glu Gly Arg Trp His Gly Val Met Ala Gln His Gly Lys 
    130                 135                 140                 


Asn Pro Asp Gln Ile Ala Ala Arg Leu Phe Asp His Leu His Asn Ser 
145                 150                 155                 160 


Glu Leu Arg Phe Gly Gly Thr Ala Ser Gly Glu Pro Arg Thr Arg Pro 
                165                 170                 175     


Gly Lys Glu Ala Thr Pro Thr Gly Leu Ile Gly Ala Arg Ala Lys Thr 
            180                 185                 190         


Ile Glu His Ser Val Leu Pro Arg Asp Ala Lys Arg Phe Val Ala Glu 
        195                 200                 205             


Trp Arg Gly Glu Asp Gln Glu Arg Tyr Ala Gly Ala Arg Asp Ile Ala 
    210                 215                 220                 


Ala Ala Ile Ser Ala Gly Leu Asn Asp Lys Asp Gln Lys Ser Gly Ser 
225                 230                 235                 240 


Gly Arg Lys Ser Ala Val Ile Gly Lys Leu Leu Ser Asp His Leu Glu 
                245                 250                 255     


Thr Leu Thr Gly Asn Arg Lys Cys Arg Phe Asp Pro Lys Ser Thr Ala 
            260                 265                 270         


Glu Thr Leu Glu Leu Arg Asp Gly Glu Ser Val Asp Asp Arg Arg Arg 
        275                 280                 285             


Ile Leu Glu Leu His Ala Glu Val Lys Ala Thr Tyr Lys Arg Met Ala 
    290                 295                 300                 


Ala Trp Lys Pro Ala Lys Leu Pro Arg Asn Ser Asp Glu Leu Phe Arg 
305                 310                 315                 320 


Leu Val Arg Gln Gln Ala Asp Asn Arg Ile Leu Asn His Leu Val Arg 
                325                 330                 335     


Val Gly Arg Ile Ser Val Tyr Ser Glu Gln Ser Asp Ala Leu Ser Glu 
            340                 345                 350         


Ser Gln Phe Trp Thr Ser Gly Gly Gln Thr Gln Ile Lys Glu Ser Glu 
        355                 360                 365             


Val Phe Ala Arg Leu Trp Ile Gly Ala Ile Ser Arg Ala Ser Tyr Ser 
    370                 375                 380                 


Met Lys Ala Trp Leu Glu Pro Glu Gly Thr Val Phe Asn Pro Ser Ile 
385                 390                 395                 400 


Asn Asp Phe Asp Val Thr Ser Ser His Asn Thr Asn Arg Ile Leu Glu 
                405                 410                 415     


Asp Ser Gly Arg Leu Ser Asn Ala Met Ala Arg Arg Ala Ile Tyr Phe 
            420                 425                 430         


Gly Glu Thr Pro Glu Phe Asp Ala Leu Gly Glu Glu Asp Gln Arg Val 
        435                 440                 445             


Leu Val Lys Lys Cys Leu Asp Ala Leu Ser Ala Cys Arg Asn Arg Thr 
    450                 455                 460                 


Phe His His Gly Gln Arg Ala Lys Phe Leu Lys Glu Val Arg Lys Gly 
465                 470                 475                 480 


Leu Lys Glu Lys Glu Ala Asp Ser Ala Gly Pro Ala Ala Trp Glu Gly 
                485                 490                 495     


Ile Arg Glu Val Ile Gln Ala Asp Ala Arg Asn Leu Gly Ala Arg Leu 
            500                 505                 510         


Leu Gln Asp Leu Thr Gly Ala Lys Val His Ser Phe Ala Thr Asp Pro 
        515                 520                 525             


Glu Phe Arg His Leu Tyr Glu Ser Val Ala Ala Thr Leu Thr Ala Gly 
    530                 535                 540                 


Gly Glu Leu Glu Ala Ala Leu Pro Arg Leu Lys Asn Val Leu Lys Arg 
545                 550                 555                 560 


Ala Glu Gly Val Arg Cys Tyr Leu Asp Thr Pro Ser Gln Arg Arg Glu 
                565                 570                 575     


Gly Asp Glu Ser Leu Ile Ala Arg Leu Pro Val Ala Pro Val Pro Arg 
            580                 585                 590         


Glu Leu Asp Asp Ala Ala Thr Lys Ala Arg His Ser Ala Leu Leu Arg 
        595                 600                 605             


Leu Tyr Asp Gly Pro Phe Arg Pro Trp Ala Thr Glu Leu Arg Gly Glu 
    610                 615                 620                 


Arg Leu Ser Asp Tyr Ala Ala Arg Ala Lys Arg Leu Ala Thr Arg Leu 
625                 630                 635                 640 


Ala Lys Ser Thr Asn Thr Ala Ser Pro Tyr Pro Asp Ser Val Glu Gly 
                645                 650                 655     


Arg Ser Val Arg Leu Arg Asp Pro Ile Thr Ala Asp Thr Ala Pro Glu 
            660                 665                 670         


Thr Leu Lys Thr Tyr Leu Ser Ala Leu Thr Ala Glu Thr Ala Thr Glu 
        675                 680                 685             


Phe Arg Val Gln Lys Gly Tyr Glu Ser Asp Gly Glu Lys Ala Lys Glu 
    690                 695                 700                 


Gln Ala Glu Phe Ile Glu Asp Phe Arg Arg Asp Met Ile Ala Leu Ala 
705                 710                 715                 720 


Phe Gln Asp Phe Ile Arg Asp His Gly Phe Ala Trp Leu Leu Asp Ile 
                725                 730                 735     


Ala Ser Lys Ala Glu Pro Ser Asn Asp Ala Pro Asn Leu Pro Asp Pro 
            740                 745                 750         


Val Asp Thr Gly Lys Asp Thr Val Phe Glu Asp Trp Gln Ala Leu Leu 
        755                 760                 765             


Tyr Leu Phe Leu His Phe Val Pro Ala Asp Asp Val Ser Gln Leu Leu 
    770                 775                 780                 


His Gln Leu Arg Lys Trp Asp Ala Leu Gln Asp Lys Tyr Glu Leu Ala 
785                 790                 795                 800 


Glu Pro Gly Glu Thr Leu Gly Gln Thr Lys Ala Asp Thr Arg Lys Ile 
                805                 810                 815     


Val Gly Gln Phe Arg Asp Cys Leu Thr Leu Phe Leu Lys Thr Gly Asp 
            820                 825                 830         


Ala Arg Phe Asp Gly Glu Gly Val Glu Leu Pro Leu Ser Asp Phe Gln 
        835                 840                 845             


Glu Leu Phe Glu Ser Pro Ala Thr Phe Lys Glu Leu Phe Leu Ala Glu 
    850                 855                 860                 


Pro Ala Glu Asn Asp Ala Ser Glu Thr Asp Asp Gln Asp Ala Pro Gly 
865                 870                 875                 880 


Glu Lys His Arg Val Thr Arg Thr Arg Arg Gly Leu Arg Gln Ile Leu 
                885                 890                 895     


Arg Tyr Asn His Met Pro Val Leu Arg Asp Leu Phe Leu Ala His Lys 
            900                 905                 910         


Val Thr Asp Ala Glu Val Asp Gly Leu Gln Ala Leu Glu Val Asp Asp 
        915                 920                 925             


Pro Gln Thr Gly Glu Ser Gln Ile Gly Ala Ala Gln Arg Ile Arg Thr 
    930                 935                 940                 


Glu Ile His His His Thr Ser Asn Asp Lys Gln Ile Ser Glu Ala Lys 
945                 950                 955                 960 


Val Glu Glu Tyr Arg Arg Ala Leu Ser Thr Ile Glu Arg His Arg Phe 
                965                 970                 975     


Leu Val Gly Arg Val Tyr Leu Gly Asp His Ile Arg Val His Lys Leu 
            980                 985                 990         


Met Met Asp Val Met Gly Arg Leu  Val Asp Phe Ala Gly  Ala Trp Glu 
        995                 1000                 1005             


Arg Glu  Ala Ala Asp Gly Asp  Arg Lys Gly Phe Ile  Ser Arg Ala 
    1010                 1015                 1020             


Ile Ala  Leu Pro Glu Val Ala  Glu Gly Tyr Ala Ala  Asp Arg Leu 
    1025                 1030                 1035             


Lys Thr  Val Ala Arg Arg Val  Leu Asp Asp Gly Glu  Ala Arg Arg 
    1040                 1045                 1050             


Ile Arg  Asn Asp Leu Gly His  Phe Asn Asp Leu Ala  Pro Thr Ser 
    1055                 1060                 1065             


Gly Pro  Ala Asn Leu Thr Phe  Val Val Asn Arg Ala  Arg Arg Met 
    1070                 1075                 1080             


Met Arg  His Asp Arg Lys Arg  Lys Asn Ala Val Thr  Lys Ser Val 
    1085                 1090                 1095             


Ile Glu  Ile Leu Asn Arg Gln  Gly Leu Gly Ile Glu  Trp Thr Met 
    1100                 1105                 1110             


Arg Asn  His Glu Leu Cys Glu  Ala Lys Leu Trp Gln  Asn Pro Val 
    1115                 1120                 1125             


Lys His  Leu Gly Phe Ala Thr  Leu Glu Gly Arg Gly  Lys Lys Trp 
    1130                 1135                 1140             


Arg Arg  Pro Phe Glu Ala Arg  Tyr Gly Asp Ala Tyr  Met Ala Met 
    1145                 1150                 1155             


Val Ala  Gln Leu Phe Asp Gly  Thr Val Thr Ser Pro  Pro Ala Lys 
    1160                 1165                 1170             


Gly Pro  Pro Gln Ser Gly Lys  Ser Gly Gly Lys Pro  Gly Lys Gly 
    1175                 1180                 1185             


Ala Glu  Gly Gly Ala Lys Glu  Lys Ser Arg Ser Pro  Thr Arg Met 
    1190                 1195                 1200             


Glu Glu  Gly Gly Val Tyr Glu  Gly Arg Val Ala Lys  Ala Lys Ser 
    1205                 1210                 1215             


Asp Lys  Gly Phe Gly Phe Leu  Leu Val Glu Gly Ala  Gln Glu Glu 
    1220                 1225                 1230             


Ile Phe  Leu His Ile Tyr Gly  Ile Ser Gly Asn Arg  Pro Ala Arg 
    1235                 1240                 1245             


Ile Glu  Asn Gly Gln Arg Tyr  Arg Phe Thr Leu Gly  Ile Asp Arg 
    1250                 1255                 1260             


Asp Arg  Glu Arg Arg Lys Glu  Arg Ala Trp Val Ala  Arg Glu Ala 
    1265                 1270                 1275             


Val Arg  Ile Asp Glu Asn Arg  Ser Lys 
    1280                 1285         


<210>  797
<211>  1373
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  797

Met Ala Lys His Leu Arg Pro Ile Gly Glu Ser Tyr Thr Asp Phe Leu 
1               5                   10                  15      


Asp Glu Thr Glu Phe Val Arg Leu Gly Arg Gly Leu His Arg Gly His 
            20                  25                  30          


His Gly Val Gln Ile Pro Pro Thr Glu Leu Pro Ser Tyr Leu Ala Glu 
        35                  40                  45              


Tyr Arg Lys Ala Leu Met Arg Gln Val Val Ala Val Leu Asp Lys Val 
    50                  55                  60                  


Val Gly Lys Arg Arg Arg Leu Ser Gly Met His Pro Glu Ala Tyr Arg 
65                  70                  75                  80  


Asp Arg Val His Leu Ala Glu Ala Leu Trp Val Arg Leu Val Ala Arg 
                85                  90                  95      


Val Lys Glu Ile Gly Thr Pro Pro Asp Pro Ser Glu Leu Leu Asp Leu 
            100                 105                 110         


Arg Arg Met Trp Asn Ala Lys Ala His Pro Tyr Ala Glu Tyr Asp Val 
        115                 120                 125             


Val Pro Arg Ala Pro Leu Asn Asp Gly Asn Gly Gln Lys Ile Leu Glu 
    130                 135                 140                 


Cys Arg Glu Val Asp Asp Pro Lys Ile Glu Arg Ser Asp Phe Glu Gly 
145                 150                 155                 160 


Arg Trp His Gly Arg Phe Trp Gln Ser Glu Pro Gly Pro Val Asp Tyr 
                165                 170                 175     


Asn Ala Ile Ala Asp Arg Ile Phe Ala His Leu Phe Asp Gln Glu Ala 
            180                 185                 190         


Val Ile Gly Gly Gly Pro Arg Arg Glu Gly Asn Val Thr Val Pro Asp 
        195                 200                 205             


Glu Asp Ile Asn Gly Gln Pro Gly Pro Ala Thr Gly Lys Gly Leu Ile 
    210                 215                 220                 


Ile Ala Arg Gly Gln Ser Ile Val Lys Ser Ala Ser Asp Pro Arg Arg 
225                 230                 235                 240 


Ser Ser Lys Lys Val Gln Arg Thr Trp Asp Lys Ala Val Glu Arg Arg 
                245                 250                 255     


Tyr Phe Gly Asp Asp Gly Lys Gly Gly Ser Asp Ile Ala Lys Ala Ile 
            260                 265                 270         


Tyr Glu Glu Leu Gly Asp Pro Ala Thr Leu Ala Asp Pro Ile Tyr Ala 
        275                 280                 285             


Ser Trp Phe Gly Ser Arg Leu Tyr Asp His Phe Gly Ser Phe Lys Asn 
    290                 295                 300                 


Ser Leu Pro Leu Glu Leu Lys Asp Pro Phe Lys Glu Gln Ile Trp Ala 
305                 310                 315                 320 


Leu His Asn Ser Val Arg Gln Phe Tyr Gln Arg Met Ala Lys Ser Asp 
                325                 330                 335     


Arg Phe Arg Leu Ala Leu Gln Asn Ala Arg Ser Glu Val Pro Asp Arg 
            340                 345                 350         


Ser Glu Leu Leu Ala Leu Leu Pro Lys Asp His Asp His Leu Leu Leu 
        355                 360                 365             


Val Leu Gly Gly Lys Lys Lys Asn Ala Glu Met Ser Glu Leu Ile Arg 
    370                 375                 380                 


Leu Gly Lys Leu Phe Val His Ala Ser Asp Val Leu His Asp Phe Asp 
385                 390                 395                 400 


Ala Asn Asp Ala Ala Ala Leu Asp Ala Phe Lys Arg Arg Met Ser Phe 
                405                 410                 415     


Leu Ala Thr Ser Ile Gly Gln Ser Glu Ile Lys Gln Thr Glu Thr Phe 
            420                 425                 430         


Ala Arg Thr Trp Arg Gly Ala Val Gly Leu Thr Leu Arg Thr Val Lys 
        435                 440                 445             


Gly Leu Ala Asp Pro Arg Gly Ile Ile Gly Thr Pro Asp Asn Arg Asp 
    450                 455                 460                 


Leu Gly Thr Ala Gly Pro Met Lys Asp Ala Phe Asn Lys Phe Asp Gln 
465                 470                 475                 480 


Pro His Phe Gln Gln His Met Thr Ile Ile Phe Gly Asn Lys Glu Leu 
                485                 490                 495     


Gln Ala Glu Gly Asn Pro Thr Arg Ser Ser Val Phe Thr Ala Asn Gly 
            500                 505                 510         


Asp Lys Asp His Gln Ala Glu Leu Leu Trp Gly Phe Leu Cys Val Val 
        515                 520                 525             


Arg Ser Val Arg Asn Arg Thr Asn His Tyr Asn Val Arg Arg Ala Leu 
    530                 535                 540                 


Leu Arg Leu Leu Asp Glu Gly Ile Val Ser Pro Met Pro Ser Asp Pro 
545                 550                 555                 560 


Lys Lys Glu Arg Val Glu Asn Arg Asn Leu Cys Thr Val Ser Pro Thr 
                565                 570                 575     


Ala Leu Glu Ala Phe Arg Arg Leu Leu Asn Phe Asp Leu Ala Ile Gln 
            580                 585                 590         


Lys Glu Ala Val Arg Thr Ala Leu Glu Gln Ala Lys Ala Ser Glu Phe 
        595                 600                 605             


Val Glu Glu Gly Lys Leu Arg Gly Leu Val Ser Glu Leu Ala Gly Thr 
    610                 615                 620                 


Glu Asp Met Pro Ala Leu His Ile Pro Arg Phe Ser Ala Val Met Asp 
625                 630                 635                 640 


Lys Val Arg Arg Leu Ala Asp Asn Arg Asp Val Gly Leu Asp Pro Ile 
                645                 650                 655     


Leu Ser Thr Leu Gln Arg Ser Leu Pro Pro Thr Asp Lys Gln Ala Glu 
            660                 665                 670         


Ser Asp Ala Ala Arg Cys Arg Tyr Arg Leu Leu Leu Glu Leu Tyr Lys 
        675                 680                 685             


Ser Gly Phe Arg Ser Trp Phe Ser Gly Ile Gln Ser Asn Glu Glu Asn 
    690                 695                 700                 


Asn Arg Glu Ile Cys His Trp Ala Val Lys Gln Val Gly Arg Ala Lys 
705                 710                 715                 720 


Asp Ala Arg Lys Ser Glu Tyr Asp Lys Lys Thr Lys Arg His Tyr Arg 
                725                 730                 735     


Ser Pro Asn Ser Leu Ile Asp Asp Leu Gly Leu Asp Lys Phe Asp Asp 
            740                 745                 750         


Leu Thr Asp Leu Leu Glu Ala Leu Ala Ser Gln Ser Thr Arg Glu His 
        755                 760                 765             


Asp Gln Asn Leu Lys Tyr Val Pro Asp Ala Arg Val Gln Ser Gln Met 
    770                 775                 780                 


Ser Asn Arg Ile Glu Glu Phe Arg Gln Glu Leu Phe Ala His Ile Phe 
785                 790                 795                 800 


Thr Lys Tyr Leu Asp Thr His Asp Phe Gly Trp Ile Gly Ala Ile Glu 
                805                 810                 815     


Val Arg Arg Glu Ala Cys Asp Leu Ala Asp Val Val Ser Ala Phe Glu 
            820                 825                 830         


Val Arg Asp Gln Lys Phe Asp Ala Asp Trp His Ser Gln Phe Tyr Ala 
        835                 840                 845             


Trp Leu Tyr Met Val Pro Pro Ile Glu Ala Ser Arg Leu Arg His Gln 
    850                 855                 860                 


Met Arg Lys Ser Ala Val Met Asp Asp Lys Trp Ser Thr Thr Leu Glu 
865                 870                 875                 880 


Leu Thr Ser Gly Asp Arg Lys Thr Arg Asp Asp His Ala Gln Asp Val 
                885                 890                 895     


Leu Ala Asp Met Asp Arg Leu Phe Ser Leu Tyr Thr Lys Val Gln Ala 
            900                 905                 910         


Ala Gly Phe Asn Gly Gln Glu His Glu Ser Ala Leu Gly Ser Lys Ser 
        915                 920                 925             


Leu Phe Tyr Glu Asp Gly Asn Gln Phe Asp Glu Val Tyr Ser Pro Asp 
    930                 935                 940                 


Thr Glu Thr His Asn Lys Thr Phe Pro Gly Thr Arg Arg Gly Leu Arg 
945                 950                 955                 960 


Gln Leu Val Arg Tyr Ala His Leu Pro Ala Leu Glu Gly Val Phe Lys 
                965                 970                 975     


Lys His Arg Ile Thr Lys Ala Glu Val Glu Thr Phe Val Ala Leu Tyr 
            980                 985                 990         


Asp Glu Asn Arg Arg Asp Pro Gly  Ser Val Ala His Met  Leu Arg Arg 
        995                 1000                 1005             


Glu Lys  Leu Arg Thr Glu Ile  Leu Arg Ser Ile His  Asp Gly Pro 
    1010                 1015                 1020             


Lys Pro  Lys Asp Lys Asp Phe  Trp Pro Lys Leu Glu  Ala Lys Cys 
    1025                 1030                 1035             


Leu Glu  Tyr Arg Thr Val Ala  Thr Glu Thr Ala Ile  Tyr Asn Phe 
    1040                 1045                 1050             


Gln Ala  Asn Ala Ala Arg Leu  Asn Asp His Ala Arg  Leu His Gln 
    1055                 1060                 1065             


Ile Val  Met Arg Val Val Ala  Arg Leu Thr Asp Tyr  Ala Leu Ile 
    1070                 1075                 1080             


Trp Glu  Arg Asp Arg Leu Phe  Ala Phe Val Gly Met  Leu Tyr Arg 
    1085                 1090                 1095             


Gln Thr  Gly Gly Thr Gly Ile  Asn Pro Ala Met Arg  His Ala Glu 
    1100                 1105                 1110             


Lys Thr  Asn Ala Pro Pro Arg  Ile Gly Ile Leu Val  Ser Asp Ser 
    1115                 1120                 1125             


Ala Leu  Ala Lys Lys Leu Asn  Ser Asn Ser Ala Glu  Val Phe Ile 
    1130                 1135                 1140             


Pro Tyr  Leu Asp Thr Glu Thr  Gly Phe Asp Ala Pro  Arg Phe Asp 
    1145                 1150                 1155             


Asp Leu  Cys Thr Leu Leu Ser  His Glu His Ala Lys  Glu Phe Arg 
    1160                 1165                 1170             


Phe His  Phe Leu Glu Val Gly  Glu Glu Asn Ser Lys  Asp Glu Ala 
    1175                 1180                 1185             


Arg Arg  Leu Asn Glu Glu Thr  Met Gly His Arg Lys  Arg Pro Ala 
    1190                 1195                 1200             


Phe Lys  Arg Gly Thr Arg Arg  Gln Gly Ile Arg Asn  Asp Leu Ala 
    1205                 1210                 1215             


His His  Asn Val Leu Asp Leu  Ala Gly Gly Ala Gly  Pro Asn Leu 
    1220                 1225                 1230             


Thr Tyr  Val Val Asn Ala Val  Arg Ser Leu Leu Ser  Tyr Asp Arg 
    1235                 1240                 1245             


Lys Leu  Lys Asn Ala Val Pro  Lys Ser Ile Lys Arg  Ile Leu Gly 
    1250                 1255                 1260             


Glu Glu  Gly Leu Ile Ile Glu  Trp Gln Met Asn Tyr  Asp Arg Leu 
    1265                 1270                 1275             


Lys Lys  Pro Thr Val Tyr Pro  Asn Val Glu Thr His  Leu Thr Met 
    1280                 1285                 1290             


Val Pro  Pro Arg His Met Thr  Ala Pro Val Ser Phe  Thr Leu Pro 
    1295                 1300                 1305             


Arg Ala  Ser Val Arg Leu Ala  Ser Met Val Lys Ala  Val Phe Asp 
    1310                 1315                 1320             


Phe Gly  Ser Ser Gly Tyr Gly  Glu Glu Arg Met Ile  Gly Gly Arg 
    1325                 1330                 1335             


Thr Ala  Lys Gln Ala Val Tyr  Pro Asp Asp Phe Thr  Arg Arg Phe 
    1340                 1345                 1350             


Pro Gln  Thr Pro Met Gly Leu  Lys Gln Ala Thr Arg  Leu Val Phe 
    1355                 1360                 1365             


Ala Ser  Glu Asn Ser 
    1370             


<210>  798
<211>  1385
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  798

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Lys Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn Gln Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Glu 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Ile Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Asn Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Val Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Phe Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Gln Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Arg Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Met Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Val Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asp Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Met Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Ile Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Cys Ile  Ser Ser Ile Lys Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Thr Leu Ile Thr Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Leu Leu Tyr  Tyr Pro Asp 
    1310                 1315                 1320             


Ile Glu  Ser Asn Val Lys Ile  Leu Leu Arg Lys Asp  Asn Phe Asn 
    1325                 1330                 1335             


Gln Asn  Lys Asp Lys Lys Asn  Val Asn Asn Arg Lys  Thr Lys Asn 
    1340                 1345                 1350             


Asn Asn  Lys Asn Gly Asn Arg  Asn Arg Asp Lys Asn  Ser Gly Gly 
    1355                 1360                 1365             


Asp Gly  Leu Thr Tyr Asn Pro  Phe Leu Asn Leu Ile  Phe Asp Leu 
    1370                 1375                 1380             


Pro Glu  
    1385 


<210>  799
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  799

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  800
<211>  1385
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  800

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Pro Gly Thr Asp Thr 
            20                  25                  30          


Ile Asp Leu Asn Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Thr Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Asp Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Glu Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Gly Leu Phe Val Asn Ile 
                325                 330                 335     


Pro Asp Val Leu Met Lys Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Ile Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Ser Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg 
465                 470                 475                 480 


Asn Gly Ile Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Tyr Glu Asn 
                485                 490                 495     


Leu Gln Arg Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu 
            500                 505                 510         


Ala Arg Ala Val Cys Asp Met Ser Asn Leu Lys Asp Arg Glu Ser Asp 
        515                 520                 525             


Phe Leu Leu Trp Lys Lys Glu Asp Ile Ala Asp Lys Leu Lys Asn Lys 
    530                 535                 540                 


Asp Asp Met Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys 
545                 550                 555                 560 


Ser Ser Trp Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn 
                565                 570                 575     


Lys Tyr Asn Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile 
            580                 585                 590         


Tyr Cys Ala Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn 
        595                 600                 605             


Asn Glu Lys Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu 
    610                 615                 620                 


Thr Glu Phe Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn 
625                 630                 635                 640 


Leu Tyr Met Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Gln 
                645                 650                 655     


Leu Tyr Ser Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn 
            660                 665                 670         


Ser Val Phe Ile Arg Lys Asn Phe Pro Glu Asp Ile Thr Asn Val Leu 
        675                 680                 685             


Arg Tyr Gln Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr 
    690                 695                 700                 


Ser Ala Cys Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu 
705                 710                 715                 720 


Gln Ser Asp Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu 
                725                 730                 735     


Ser Trp Asp Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn 
            740                 745                 750         


His Phe Ser Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys 
        755                 760                 765             


Gln Ile Tyr Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys 
    770                 775                 780                 


Val Arg Ser Ser Asn Asp Ser Ile Phe Asp Lys Pro Ile Tyr His His 
785                 790                 795                 800 


Tyr Lys Val Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr 
                805                 810                 815     


Leu Lys Tyr Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys 
            820                 825                 830         


Ala Asn Glu Ile Arg Lys Ile Asp Lys Glu Arg Phe Leu Pro Asp Trp 
        835                 840                 845             


Thr Ser Thr Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln 
    850                 855                 860                 


Glu Leu Gln Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser 
865                 870                 875                 880 


Leu Asn Leu Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr 
                885                 890                 895     


Asp Ile Lys Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser 
            900                 905                 910         


Val Gln Asp Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val 
        915                 920                 925             


Cys Ser Leu Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe 
    930                 935                 940                 


Asn Asp Lys Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe 
945                 950                 955                 960 


Ser Asn Ala Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser 
                965                 970                 975     


Asn Glu Glu Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val 
            980                 985                 990         


Asn Arg Asn Ile Val His Ser Lys  Leu Phe Ala Ala Asp  His Ile Leu 
        995                 1000                 1005             


Arg Asp  Ile Val Glu Pro Val  Ser Lys Asp Asn Ile  Glu Glu Phe 
    1010                 1015                 1020             


Tyr Asp  Gln Lys Ala Glu Ile  Val Tyr Cys Lys Ile  Lys Gly Lys 
    1025                 1030                 1035             


Asp Ile  Thr Ala Glu Glu Gln  Lys Ala Val Leu Lys  Tyr Gln Lys 
    1040                 1045                 1050             


Leu Lys  Asn Arg Val Glu Leu  Arg Asp Ile Val Glu  Tyr Gly Glu 
    1055                 1060                 1065             


Ile Ile  Asn Glu Leu Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met 
    1070                 1075                 1080             


Arg Glu  Arg Asp Leu Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn 
    1085                 1090                 1095             


Cys Leu  Arg Asn Asn Ser Glu  Lys Lys Glu Ala Tyr  Gln Lys Ile 
    1100                 1105                 1110             


Glu Val  Asn Gly Asp Ser Ile  Lys Asp Ala Ile Leu  Tyr Gln Ile 
    1115                 1120                 1125             


Ile Gly  Met Tyr Val Asn Gly  Val Ala Val Tyr Ala  Pro Asp Glu 
    1130                 1135                 1140             


Lys Gly  Asp Ile Leu Lys Glu  Gln Cys Thr Lys Gly  Gly Ala Gly 
    1145                 1150                 1155             


Gly Lys  Ile Ser Ala Phe Asn  Arg Tyr Ser Glu Tyr  Leu Gly Leu 
    1160                 1165                 1170             


Asp Lys  Leu Thr Leu Tyr Asn  Ala Gly Leu Glu Ile  Phe Glu Val 
    1175                 1180                 1185             


Val Ala  Glu His Asp Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp 
    1190                 1195                 1200             


His Phe  Lys Tyr Tyr Leu Gly  Asp Tyr Arg Ser Met  Leu Ser Ile 
    1205                 1210                 1215             


Tyr Ser  Glu Val Phe Asp Arg  Phe Phe Thr Tyr Asp  Ile Lys Tyr 
    1220                 1225                 1230             


Gln Lys  Asn Val Leu Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His 
    1235                 1240                 1245             


Asn Val  Ile Val Glu Pro Val  Leu Glu Ser Gly Phe  Lys Thr Ile 
    1250                 1255                 1260             


Gly Lys  Gln Thr Thr Ser Gly  Ala Lys Leu Ser Ile  Arg Ser Ile 
    1265                 1270                 1275             


Lys Ser  Asp Thr Phe Gln Tyr  Lys Val Lys Gly Gly  Ser Leu Ile 
    1280                 1285                 1290             


Thr Asp  Ala Lys Asp Glu Arg  Tyr Leu Lys Thr Ile  Arg Lys Ile 
    1295                 1300                 1305             


Leu Tyr  Tyr Val Glu Asn Glu  Glu Asp Asn Leu Lys  Lys Ser Val 
    1310                 1315                 1320             


Val Val  Thr Asn Ala Asp Lys  Tyr Glu Lys Asn Lys  Glu Ser Asp 
    1325                 1330                 1335             


Asp Gln  Asn Lys Gln Lys Glu  Lys Lys Asn Lys Asp  Asn Lys Gly 
    1340                 1345                 1350             


Lys Lys  Asn Glu Glu Thr Lys  Ser Asp Ala Gly Lys  Asn Asn Asn 
    1355                 1360                 1365             


Glu Arg  Leu Ser Tyr Asn Pro  Phe Ala Asn Leu Asn  Phe Lys Leu 
    1370                 1375                 1380             


Pro Asn  
    1385 


<210>  801
<211>  1287
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  801

Met Arg Ile Gly Lys Val Gln Gly Arg Thr Phe Thr Gly Phe Asp Asn 
1               5                   10                  15      


Ala Arg Gly Lys Thr Leu Arg Arg Arg Leu Leu Thr Arg Pro Asp Asn 
            20                  25                  30          


Glu Ala Arg Ser Leu Ser Glu His Leu Ala His Asp Pro Lys Ala Leu 
        35                  40                  45              


Ile Gly Gln Ala Ile Ser Arg Ile Asp Thr Ile Tyr Gln Lys Pro Lys 
    50                  55                  60                  


Thr Gly Lys Pro Thr Pro Glu Gln Phe Gly His Arg Asp Thr Leu Gly 
65                  70                  75                  80  


Trp Ala Tyr Trp Lys Leu Leu Val Ala Ser Tyr Pro Glu Val Glu Gly 
                85                  90                  95      


His Arg Asp Leu Phe Val Arg Arg Leu His Pro Tyr Gly Asp Thr Pro 
            100                 105                 110         


Pro Lys Ser His Gly Gln Lys Glu Gly Glu His Gln Lys Gly Gly Lys 
        115                 120                 125             


Pro Gln Leu Glu Gly Arg Trp His Gly Val Met Ala Gln His Gly Lys 
    130                 135                 140                 


Asn Pro Asp Gln Ile Ala Ala Arg Leu Phe Asp His Leu His Asn Ser 
145                 150                 155                 160 


Glu Leu Arg Phe Gly Gly Thr Ala Ser Gly Glu Pro Arg Thr Arg Pro 
                165                 170                 175     


Gly Lys Glu Ala Thr Pro Thr Gly Leu Ile Gly Ala Arg Ala Lys Thr 
            180                 185                 190         


Ile Glu His Ser Val Leu Pro Arg Asp Ala Lys Arg Phe Val Ala Glu 
        195                 200                 205             


Trp Arg Gly Glu Asp Gln Glu Arg Tyr Ala Gly Ala Arg Asp Ile Ala 
    210                 215                 220                 


Ala Ala Ile Ser Ala Gly Leu Asn Asp Lys Asp Gln Lys Ser Gly Ser 
225                 230                 235                 240 


Gly Arg Lys Ser Ala Val Ile Gly Lys Leu Leu Ser Asp His Leu Glu 
                245                 250                 255     


Thr Leu Thr Gly Asn Arg Lys Cys Arg Phe Asp Pro Lys Ser Thr Ala 
            260                 265                 270         


Glu Thr Leu Glu Leu Arg Asp Gly Glu Ser Val Asp Asp Arg Arg Arg 
        275                 280                 285             


Ile Leu Glu Leu His Ala Glu Val Lys Ala Thr Tyr Lys Arg Met Ala 
    290                 295                 300                 


Ala Trp Lys Pro Ala Lys Leu Pro Arg Asn Ser Asp Glu Leu Phe Arg 
305                 310                 315                 320 


Leu Val Arg Gln Gln Ala Asp Asn Arg Ile Leu Asn His Leu Val Arg 
                325                 330                 335     


Val Gly Arg Ile Ser Val Tyr Ser Glu Gln Ser Asp Ala Leu Ser Glu 
            340                 345                 350         


Ser Gln Phe Trp Thr Ser Gly Gly Gln Thr Gln Ile Lys Glu Ser Glu 
        355                 360                 365             


Val Phe Ala Arg Leu Trp Ile Gly Ala Ile Ser Arg Ala Ser Tyr Ser 
    370                 375                 380                 


Met Lys Ala Trp Leu Glu Pro Glu Gly Thr Val Phe Asn Pro Ser Ile 
385                 390                 395                 400 


Asn Asp Phe Asp Val Thr Ser Ser His Asn Thr Asn Arg Ile Leu Glu 
                405                 410                 415     


Asp Ser Gly Arg Leu Ser Asn Ala Met Ala Arg Arg Ala Ile Tyr Phe 
            420                 425                 430         


Gly Glu Thr Pro Glu Phe Asp Ala Leu Gly Glu Glu Asp Gln Arg Val 
        435                 440                 445             


Leu Val Lys Lys Cys Leu Asp Ala Leu Ser Ala Cys Arg Asn Arg Thr 
    450                 455                 460                 


Phe His His Gly Gln Arg Ala Lys Phe Leu Lys Glu Val Arg Lys Gly 
465                 470                 475                 480 


Leu Lys Glu Lys Glu Ala Asp Ser Ala Gly Pro Ala Ala Trp Glu Gly 
                485                 490                 495     


Ile Arg Glu Val Ile Gln Ala Asp Ala Arg Asn Leu Gly Ala Arg Leu 
            500                 505                 510         


Leu Gln Asp Leu Thr Gly Ala Lys Val His Ser Phe Ala Thr Asp Pro 
        515                 520                 525             


Glu Phe Arg His Leu Tyr Glu Ser Val Ala Ala Thr Leu Thr Ala Gly 
    530                 535                 540                 


Gly Glu Leu Glu Ala Ala Leu Pro Arg Leu Lys Asn Val Leu Lys Arg 
545                 550                 555                 560 


Ala Glu Gly Val Arg Cys Tyr Leu Asp Thr Pro Ser Gln Arg Arg Glu 
                565                 570                 575     


Gly Asp Glu Ser Leu Ile Ala Arg Leu Pro Val Ala Pro Val Pro Arg 
            580                 585                 590         


Glu Leu Asp Asp Ala Ala Thr Lys Ala Arg His Ser Ala Leu Leu Arg 
        595                 600                 605             


Leu Tyr Asp Gly Pro Phe Arg Pro Trp Ala Thr Glu Leu Arg Gly Glu 
    610                 615                 620                 


Arg Leu Ser Asp Tyr Ala Ala Arg Ala Lys Arg Leu Ala Thr Arg Leu 
625                 630                 635                 640 


Ala Lys Ser Thr Asn Thr Ala Ser Pro Tyr Pro Asp Ser Val Glu Gly 
                645                 650                 655     


Arg Ser Val Arg Leu Arg Asp Pro Ile Thr Ala Asp Thr Ala Pro Glu 
            660                 665                 670         


Thr Leu Lys Thr Tyr Leu Ser Ala Leu Thr Ala Glu Thr Ala Thr Glu 
        675                 680                 685             


Phe Arg Val Gln Lys Gly Tyr Glu Ser Asp Gly Glu Lys Ala Lys Glu 
    690                 695                 700                 


Gln Ala Glu Phe Ile Glu Asp Phe Arg Arg Asp Met Ile Ala Leu Ala 
705                 710                 715                 720 


Phe Gln Asp Phe Ile Arg Asp His Gly Phe Ala Trp Leu Leu Asp Ile 
                725                 730                 735     


Ala Ser Lys Ala Glu Pro Ser Asn Asp Ala Pro Asn Leu Pro Asp Pro 
            740                 745                 750         


Val Asp Thr Gly Lys Asp Thr Val Phe Glu Asp Trp Gln Ala Leu Leu 
        755                 760                 765             


Tyr Leu Phe Leu His Phe Val Pro Ala Asp Asp Val Ser Gln Leu Leu 
    770                 775                 780                 


His Gln Leu Arg Lys Trp Asp Ala Leu Gln Asp Lys Tyr Glu Leu Ala 
785                 790                 795                 800 


Glu Pro Gly Glu Thr Leu Gly Gln Thr Lys Ala Asp Thr Arg Lys Ile 
                805                 810                 815     


Val Gly Gln Phe Arg Asp Cys Leu Thr Leu Phe Leu Lys Thr Gly Asp 
            820                 825                 830         


Ala Arg Phe Asp Gly Glu Gly Val Glu Leu Pro Leu Ser Asp Phe Gln 
        835                 840                 845             


Glu Leu Phe Glu Ser Pro Ala Thr Phe Lys Glu Leu Phe Leu Ala Glu 
    850                 855                 860                 


Pro Ala Glu Asn Asp Ala Ser Glu Thr Asp Asp Gln Asp Ala Pro Gly 
865                 870                 875                 880 


Glu Lys His Arg Val Thr Arg Thr Arg Arg Gly Leu Arg Gln Ile Leu 
                885                 890                 895     


Arg Tyr Asn His Met Pro Val Leu Arg Asp Leu Phe Leu Ala His Lys 
            900                 905                 910         


Val Thr Asp Ala Glu Val Asp Gly Leu Gln Ala Leu Glu Val Asp Asp 
        915                 920                 925             


Pro Gln Thr Gly Glu Ser Gln Ile Gly Ala Ala Gln Arg Ile Arg Thr 
    930                 935                 940                 


Glu Ile His His His Thr Ser Asn Asp Lys Gln Ile Ser Glu Ala Lys 
945                 950                 955                 960 


Val Glu Glu Tyr Arg Arg Ala Leu Ser Thr Ile Glu Arg His Arg Phe 
                965                 970                 975     


Leu Val Gly Arg Val Tyr Leu Gly Asp His Ile Arg Val His Lys Leu 
            980                 985                 990         


Met Met Asp Val Met Gly Arg Leu  Val Asp Phe Ala Gly  Ala Trp Glu 
        995                 1000                 1005             


Arg Glu  Ala Ala Asp Gly Asp  Arg Lys Gly Phe Ile  Ser Arg Ala 
    1010                 1015                 1020             


Ile Ala  Leu Pro Glu Val Ala  Glu Gly Tyr Ala Ala  Asp Arg Leu 
    1025                 1030                 1035             


Lys Thr  Val Ala Arg Arg Val  Leu Asp Asp Gly Glu  Ala Arg Arg 
    1040                 1045                 1050             


Ile Arg  Asn Asp Leu Gly His  Phe Asn Asp Leu Ala  Pro Thr Ser 
    1055                 1060                 1065             


Gly Pro  Ala Asn Leu Thr Phe  Val Val Asn Arg Ala  Arg Arg Met 
    1070                 1075                 1080             


Met Arg  His Asp Arg Lys Arg  Lys Asn Ala Val Thr  Lys Ser Val 
    1085                 1090                 1095             


Ile Glu  Ile Leu Asn Arg Gln  Gly Leu Gly Ile Glu  Trp Thr Met 
    1100                 1105                 1110             


Arg Asn  His Glu Leu Cys Glu  Ala Lys Leu Trp Gln  Asn Pro Val 
    1115                 1120                 1125             


Lys His  Leu Gly Phe Ala Thr  Leu Glu Gly Arg Gly  Lys Lys Trp 
    1130                 1135                 1140             


Arg Arg  Pro Phe Glu Ala Arg  Tyr Gly Asp Ala Tyr  Met Ala Met 
    1145                 1150                 1155             


Val Ala  Gln Leu Phe Asp Gly  Thr Val Thr Ser Pro  Pro Ala Lys 
    1160                 1165                 1170             


Gly Pro  Pro Gln Ser Gly Lys  Ser Gly Gly Lys Pro  Gly Lys Gly 
    1175                 1180                 1185             


Ala Glu  Gly Gly Ala Lys Glu  Lys Ser Arg Ser Pro  Thr Arg Met 
    1190                 1195                 1200             


Glu Glu  Gly Gly Val Tyr Glu  Gly Arg Val Ala Lys  Ala Lys Ser 
    1205                 1210                 1215             


Asp Lys  Gly Phe Gly Phe Leu  Leu Val Glu Gly Ala  Gln Glu Glu 
    1220                 1225                 1230             


Ile Phe  Leu His Ile Tyr Gly  Ile Ser Gly Asn Arg  Pro Ala Arg 
    1235                 1240                 1245             


Ile Glu  Asn Gly Gln Arg Tyr  Arg Phe Thr Leu Gly  Ile Asp Arg 
    1250                 1255                 1260             


Asp Arg  Glu Arg Arg Lys Glu  Arg Ala Trp Val Ala  Arg Glu Ala 
    1265                 1270                 1275             


Val Arg  Ile Asp Glu Asn Arg  Ser Lys 
    1280                 1285         


<210>  802
<211>  1373
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  802

Met Ala Lys His Leu Arg Pro Ile Gly Glu Ser Tyr Thr Asp Phe Leu 
1               5                   10                  15      


Asp Glu Thr Glu Phe Val Arg Leu Gly Arg Gly Leu His Arg Gly His 
            20                  25                  30          


His Gly Val Gln Ile Pro Pro Thr Glu Leu Pro Ser Tyr Leu Ala Glu 
        35                  40                  45              


Tyr Arg Lys Ala Leu Met Arg Gln Val Val Ala Val Leu Asp Lys Val 
    50                  55                  60                  


Val Gly Lys Arg Arg Arg Leu Ser Gly Met His Pro Glu Ala Tyr Arg 
65                  70                  75                  80  


Asp Arg Val His Leu Ala Glu Ala Leu Trp Val Arg Leu Val Ala Arg 
                85                  90                  95      


Val Lys Glu Ile Gly Thr Pro Pro Asp Pro Ser Glu Leu Leu Asp Leu 
            100                 105                 110         


Arg Arg Met Trp Asn Ala Lys Ala His Pro Tyr Ala Glu Tyr Asp Val 
        115                 120                 125             


Val Pro Arg Ala Pro Leu Asn Asp Gly Asn Gly Gln Lys Ile Leu Glu 
    130                 135                 140                 


Cys Arg Glu Val Asp Asp Pro Lys Ile Glu Arg Ser Asp Phe Glu Gly 
145                 150                 155                 160 


Arg Trp His Gly Arg Phe Trp Gln Ser Glu Pro Gly Pro Val Asp Tyr 
                165                 170                 175     


Asn Ala Ile Ala Asp Arg Ile Phe Ala His Leu Phe Asp Gln Glu Ala 
            180                 185                 190         


Val Ile Gly Gly Gly Pro Arg Arg Glu Gly Asn Val Thr Val Pro Asp 
        195                 200                 205             


Glu Asp Ile Asn Gly Gln Pro Gly Pro Ala Thr Gly Lys Gly Leu Ile 
    210                 215                 220                 


Ile Ala Arg Gly Gln Ser Ile Val Lys Ser Ala Ser Asp Pro Arg Arg 
225                 230                 235                 240 


Ser Ser Lys Lys Val Gln Arg Thr Trp Asp Lys Ala Val Glu Arg Arg 
                245                 250                 255     


Tyr Phe Gly Asp Asp Gly Lys Gly Gly Ser Asp Ile Ala Lys Ala Ile 
            260                 265                 270         


Tyr Glu Glu Leu Gly Asp Pro Ala Thr Leu Ala Asp Pro Ile Tyr Ala 
        275                 280                 285             


Ser Trp Phe Gly Ser Arg Leu Tyr Asp His Phe Gly Ser Phe Lys Asn 
    290                 295                 300                 


Ser Leu Pro Leu Glu Leu Lys Asp Pro Phe Lys Glu Gln Ile Trp Ala 
305                 310                 315                 320 


Leu His Asn Ser Val Arg Gln Phe Tyr Gln Arg Met Ala Lys Ser Asp 
                325                 330                 335     


Arg Phe Arg Leu Ala Leu Gln Asn Ala Arg Ser Glu Val Pro Asp Arg 
            340                 345                 350         


Ser Glu Leu Leu Ala Leu Leu Pro Lys Asp His Asp His Leu Leu Leu 
        355                 360                 365             


Val Leu Gly Gly Lys Lys Lys Asn Ala Glu Met Ser Glu Leu Ile Arg 
    370                 375                 380                 


Leu Gly Lys Leu Phe Val His Ala Ser Asp Val Leu His Asp Phe Asp 
385                 390                 395                 400 


Ala Asn Asp Ala Ala Ala Leu Asp Ala Phe Lys Arg Arg Met Ser Phe 
                405                 410                 415     


Leu Ala Thr Ser Ile Gly Gln Ser Glu Ile Lys Gln Thr Glu Thr Phe 
            420                 425                 430         


Ala Arg Thr Trp Arg Gly Ala Val Gly Leu Thr Leu Arg Thr Val Lys 
        435                 440                 445             


Gly Leu Ala Asp Pro Arg Gly Ile Ile Gly Thr Pro Asp Asn Arg Asp 
    450                 455                 460                 


Leu Gly Thr Ala Gly Pro Met Lys Asp Ala Phe Asn Lys Phe Asp Gln 
465                 470                 475                 480 


Pro His Phe Gln Gln His Met Thr Ile Ile Phe Gly Asn Lys Glu Leu 
                485                 490                 495     


Gln Ala Glu Gly Asn Pro Thr Arg Ser Ser Val Phe Thr Ala Asn Gly 
            500                 505                 510         


Asp Lys Asp His Gln Ala Glu Leu Leu Trp Gly Phe Leu Cys Val Val 
        515                 520                 525             


Arg Ser Val Arg Asn Arg Thr Asn His Tyr Asn Val Arg Arg Ala Leu 
    530                 535                 540                 


Leu Arg Leu Leu Asp Glu Gly Ile Val Ser Pro Met Pro Ser Asp Pro 
545                 550                 555                 560 


Lys Lys Glu Arg Val Glu Asn Arg Asn Leu Cys Thr Val Ser Pro Thr 
                565                 570                 575     


Ala Leu Glu Ala Phe Arg Arg Leu Leu Asn Phe Asp Leu Ala Ile Gln 
            580                 585                 590         


Lys Glu Ala Val Arg Thr Ala Leu Glu Gln Ala Lys Ala Ser Glu Phe 
        595                 600                 605             


Val Glu Glu Gly Lys Leu Arg Gly Leu Val Ser Glu Leu Ala Gly Thr 
    610                 615                 620                 


Glu Asp Met Pro Ala Leu His Ile Pro Arg Phe Ser Ala Val Met Asp 
625                 630                 635                 640 


Lys Val Arg Arg Leu Ala Asp Asn Arg Asp Val Gly Leu Asp Pro Ile 
                645                 650                 655     


Leu Ser Thr Leu Gln Arg Ser Leu Pro Pro Thr Asp Lys Gln Ala Glu 
            660                 665                 670         


Ser Asp Ala Ala Arg Cys Arg Tyr Arg Leu Leu Leu Glu Leu Tyr Lys 
        675                 680                 685             


Ser Gly Phe Arg Ser Trp Phe Ser Gly Ile Gln Ser Asn Glu Glu Asn 
    690                 695                 700                 


Asn Arg Glu Ile Cys His Trp Ala Val Lys Gln Val Gly Arg Ala Lys 
705                 710                 715                 720 


Asp Ala Arg Lys Ser Glu Tyr Asp Lys Lys Thr Lys Arg His Tyr Arg 
                725                 730                 735     


Ser Pro Asn Ser Leu Ile Asp Asp Leu Gly Leu Asp Lys Phe Asp Asp 
            740                 745                 750         


Leu Thr Asp Leu Leu Glu Ala Leu Ala Ser Gln Ser Thr Arg Glu His 
        755                 760                 765             


Asp Gln Asn Leu Lys Tyr Val Pro Asp Ala Arg Val Gln Ser Gln Met 
    770                 775                 780                 


Ser Asn Arg Ile Glu Glu Phe Arg Gln Glu Leu Phe Ala His Ile Phe 
785                 790                 795                 800 


Thr Lys Tyr Leu Asp Thr His Asp Phe Gly Trp Ile Gly Ala Ile Glu 
                805                 810                 815     


Val Arg Arg Glu Ala Cys Asp Leu Ala Asp Val Val Ser Ala Phe Glu 
            820                 825                 830         


Val Arg Asp Gln Lys Phe Asp Ala Asp Trp His Ser Gln Phe Tyr Ala 
        835                 840                 845             


Trp Leu Tyr Met Val Pro Pro Ile Glu Ala Ser Arg Leu Arg His Gln 
    850                 855                 860                 


Met Arg Lys Ser Ala Val Met Asp Asp Lys Trp Ser Thr Thr Leu Glu 
865                 870                 875                 880 


Leu Thr Ser Gly Asp Arg Lys Thr Arg Asp Asp His Ala Gln Asp Val 
                885                 890                 895     


Leu Ala Asp Met Asp Arg Leu Phe Ser Leu Tyr Thr Lys Val Gln Ala 
            900                 905                 910         


Ala Gly Phe Asn Gly Gln Glu His Glu Ser Ala Leu Gly Ser Lys Ser 
        915                 920                 925             


Leu Phe Tyr Glu Asp Gly Asn Gln Phe Asp Glu Val Tyr Ser Pro Asp 
    930                 935                 940                 


Thr Glu Thr His Asn Lys Thr Phe Pro Gly Thr Arg Arg Gly Leu Arg 
945                 950                 955                 960 


Gln Leu Val Arg Tyr Ala His Leu Pro Ala Leu Glu Gly Val Phe Lys 
                965                 970                 975     


Lys His Arg Ile Thr Lys Ala Glu Val Glu Thr Phe Val Ala Leu Tyr 
            980                 985                 990         


Asp Glu Asn Arg Arg Asp Pro Gly  Ser Val Ala His Met  Leu Arg Arg 
        995                 1000                 1005             


Glu Lys  Leu Arg Thr Glu Ile  Leu Arg Ser Ile His  Asp Gly Pro 
    1010                 1015                 1020             


Lys Pro  Lys Asp Lys Asp Phe  Trp Pro Lys Leu Glu  Ala Lys Cys 
    1025                 1030                 1035             


Leu Glu  Tyr Arg Thr Val Ala  Thr Glu Thr Ala Ile  Tyr Asn Phe 
    1040                 1045                 1050             


Gln Ala  Asn Ala Ala Arg Leu  Asn Asp His Ala Arg  Leu His Gln 
    1055                 1060                 1065             


Ile Val  Met Arg Val Val Ala  Arg Leu Thr Asp Tyr  Ala Leu Ile 
    1070                 1075                 1080             


Trp Glu  Arg Asp Arg Leu Phe  Ala Phe Val Gly Met  Leu Tyr Arg 
    1085                 1090                 1095             


Gln Thr  Gly Gly Thr Gly Ile  Asn Pro Ala Met Arg  His Ala Glu 
    1100                 1105                 1110             


Lys Thr  Asn Ala Pro Pro Arg  Ile Gly Ile Leu Val  Ser Asp Ser 
    1115                 1120                 1125             


Ala Leu  Ala Lys Lys Leu Asn  Ser Asn Ser Ala Glu  Val Phe Ile 
    1130                 1135                 1140             


Pro Tyr  Leu Asp Thr Glu Thr  Gly Phe Asp Ala Pro  Arg Phe Asp 
    1145                 1150                 1155             


Asp Leu  Cys Thr Leu Leu Ser  His Glu His Ala Lys  Glu Phe Arg 
    1160                 1165                 1170             


Phe His  Phe Leu Glu Val Gly  Glu Glu Asn Ser Lys  Asp Glu Ala 
    1175                 1180                 1185             


Arg Arg  Leu Asn Glu Glu Thr  Met Gly His Arg Lys  Arg Pro Ala 
    1190                 1195                 1200             


Phe Lys  Arg Gly Thr Arg Arg  Gln Gly Ile Arg Asn  Asp Leu Ala 
    1205                 1210                 1215             


His His  Asn Val Leu Asp Leu  Ala Gly Gly Ala Gly  Pro Asn Leu 
    1220                 1225                 1230             


Thr Tyr  Val Val Asn Ala Val  Arg Ser Leu Leu Ser  Tyr Asp Arg 
    1235                 1240                 1245             


Lys Leu  Lys Asn Ala Val Pro  Lys Ser Ile Lys Arg  Ile Leu Gly 
    1250                 1255                 1260             


Glu Glu  Gly Leu Ile Ile Glu  Trp Gln Met Asn Tyr  Asp Arg Leu 
    1265                 1270                 1275             


Lys Lys  Pro Thr Val Tyr Pro  Asn Val Glu Thr His  Leu Thr Met 
    1280                 1285                 1290             


Val Pro  Pro Arg His Met Thr  Ala Pro Val Ser Phe  Thr Leu Pro 
    1295                 1300                 1305             


Arg Ala  Ser Val Arg Leu Ala  Ser Met Val Lys Ala  Val Phe Asp 
    1310                 1315                 1320             


Phe Gly  Ser Ser Gly Tyr Gly  Glu Glu Arg Met Ile  Gly Gly Arg 
    1325                 1330                 1335             


Thr Ala  Lys Gln Ala Val Tyr  Pro Asp Asp Phe Thr  Arg Arg Phe 
    1340                 1345                 1350             


Pro Gln  Thr Pro Met Gly Leu  Lys Gln Ala Thr Arg  Leu Val Phe 
    1355                 1360                 1365             


Ala Ser  Glu Asn Ser 
    1370             


<210>  803
<211>  1268
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  803

Met Lys Val Ser Lys Val Asn His Arg Arg Ala Ala Val Ala Val Asn 
1               5                   10                  15      


Lys Lys Ser Val Thr Val Asn Gly Ile Leu Tyr Asp Ala Pro Val Lys 
            20                  25                  30          


Lys Asn Val Lys Thr Gly Asn Met Ser Ala Tyr Val Ser Ser Lys Tyr 
        35                  40                  45              


Val Ile Asp Asn Val Val Lys Asn Ser Ser Arg Leu Tyr Ser Pro Phe 
    50                  55                  60                  


Ser Ser Lys Arg Ile Val Ile Asp Arg Glu Lys Ile Arg Ile Ala Asp 
65                  70                  75                  80  


Arg Leu Lys Gln Cys Tyr Val Asn Phe Val Lys Tyr Tyr Leu Ser Asn 
                85                  90                  95      


Gly Ser Leu Asn Glu Gln Gln Met Arg Phe Asn Pro Asn Asn Thr Tyr 
            100                 105                 110         


Met Ala Asp Ser Arg Val His Phe Cys Val Pro Ser Gly Ile Asp Ile 
        115                 120                 125             


Glu Ser Leu Ile Asn Ser Ile Val Asp Ser Ser Leu Arg Lys Ser Leu 
    130                 135                 140                 


Lys Arg Thr Tyr Arg Phe Glu Thr Asn Tyr Gly Glu Lys Asn Thr Phe 
145                 150                 155                 160 


Asn Leu Pro Asp Leu Val Lys Lys Ser Ile Lys Ile Tyr Cys Thr Asp 
                165                 170                 175     


Glu Lys Arg Lys Leu Asn Asp Arg Glu Glu Gln Glu Met Tyr Val Leu 
            180                 185                 190         


Phe Ser Tyr Met Tyr Glu Asp Lys Tyr Lys Asp Arg Gln Lys Val Leu 
        195                 200                 205             


Ile Ala Asn Ser Ile Ser Asn Gln Ala Thr Lys Val Lys Val Cys Asp 
    210                 215                 220                 


Asp Glu Ser Arg Leu Ile Lys Leu Ser Ile Ala Asp Thr Lys Lys Lys 
225                 230                 235                 240 


Pro Leu Trp Asp Phe Ile Val Asp Tyr Ala Asn Ser Asp Lys Asn Gly 
                245                 250                 255     


Gln Tyr Thr Ile Leu Arg Asn Ile Arg Lys Ser Ile Val Leu Phe Val 
            260                 265                 270         


Cys Gly Val Asp Val Tyr Arg Asn Ile Glu Asn Asn Asp Asn Leu Asp 
        275                 280                 285             


Ile Trp Lys Trp Glu Glu Tyr Gly Ile Gln Glu Ser Gln Leu Phe Val 
    290                 295                 300                 


Lys Ile Glu Asn Cys Tyr Thr Thr Lys Gly Glu Asp Ile Ala Leu Asn 
305                 310                 315                 320 


Glu Ile Arg Asn Val Asn Leu Asp His Tyr Met Lys Ala Ile Gly Val 
                325                 330                 335     


Leu Asp Asp Glu Arg Ser Lys Phe Trp Phe Gln His Tyr Glu Asn Thr 
            340                 345                 350         


Ile Glu Ala Leu Phe Ser Lys Lys Ser Lys Arg Lys Ile Glu Arg Ile 
        355                 360                 365             


Lys Thr Ala Tyr Leu Cys Glu Tyr Leu Trp Lys Asn Phe Cys Ser Tyr 
    370                 375                 380                 


Val Ala Leu Lys Tyr Val Asp Leu Gly Lys Gly Val Tyr His Phe Thr 
385                 390                 395                 400 


Met Ser Asp Lys Leu Ser Leu Met Asn Lys Asn Thr Asn Glu Asn Gly 
                405                 410                 415     


Ile Lys Phe Gly Glu Val Asp Ser Arg Phe Asn Lys Gly Ile Ser Ser 
            420                 425                 430         


Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Thr Ile Asp Arg Asn Ile 
        435                 440                 445             


Ser Thr Tyr Thr Thr Phe Ala Thr Asn Ile Phe Ala Lys Ser Val Ile 
    450                 455                 460                 


Lys Asp Ser Tyr Arg Gln Lys Lys Ala Gly Asn Ser Asp Ala Leu Gln 
465                 470                 475                 480 


Tyr Asp Asp Glu Thr Tyr Tyr Asn Arg Lys Ala Met Asn Pro Tyr Ala 
                485                 490                 495     


Leu Lys Arg Val Leu Arg Tyr Trp Gly Gly Gln Ser Arg Trp Lys Ser 
            500                 505                 510         


Glu Leu Glu Glu Leu Asn Val Ala Glu Leu Cys Ile Asp Ile Lys Asn 
        515                 520                 525             


Arg Leu Ser Lys Ile Arg Asn Ser Gly Val His Tyr Thr Ser Thr Ser 
    530                 535                 540                 


Ala Leu Lys Gly Asn Asp Asp Asp Ser Ile Val Gly Met Leu Ile Lys 
545                 550                 555                 560 


Lys Asp Phe Asp Asp Ile Lys Asp Val Tyr Ala Ser Lys Tyr Tyr Ser 
                565                 570                 575     


Asn Asn Val Trp Met Phe Tyr Asn Thr Asp Lys Ile Ser Lys Met Met 
            580                 585                 590         


Glu Tyr Leu Tyr Gln Asp Asp Ser Asn Ile Arg Asp Ala Gln Ile Pro 
        595                 600                 605             


Ala Phe Asn Ser Val Ile Lys Arg Lys Asp Met Ala Glu Val Ile Glu 
    610                 615                 620                 


Lys Ile Val Lys Lys Asn Ser Tyr Lys Thr Ile Lys Glu Pro Tyr Gln 
625                 630                 635                 640 


Arg Glu Lys Tyr Arg Ser Cys Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
                645                 650                 655     


Tyr Asn Arg Phe Ile Lys Gln Asp Asn Leu Lys Asp Gln Val Ile Gln 
            660                 665                 670         


Ile Ile Asp Ser Asn Thr Glu Leu Ile Gly Asp Asn Ser Arg Ala Val 
        675                 680                 685             


Asp Asn Leu Lys Lys Arg Ile His Asp Val Asp Ser Gln Thr Met Ser 
    690                 695                 700                 


Phe Gly Glu Leu Cys Gln Val Ile Met Thr Asp Tyr Asn Met Gln Asn 
705                 710                 715                 720 


Gln Glu Asn Lys Ser Ile Lys Ser Lys Glu Arg Gln Asp Lys Asp Arg 
                725                 730                 735     


Lys Asn Gly Ile Asp Asn Ser Tyr Lys His Phe Pro Leu Leu Leu His 
            740                 745                 750         


His Leu Ile Lys Val Ser Phe Leu Lys Phe Ile Lys Thr Asp Glu Lys 
        755                 760                 765             


Leu Ala Phe Ile Arg Glu Pro Arg Ile Thr Glu Trp Asp Lys Thr Leu 
    770                 775                 780                 


Glu Gln Phe Glu Ala Gln Ile Gln Thr Val Asp Ile Tyr Asn Ser Leu 
785                 790                 795                 800 


Lys Met Met Val Ala Glu Asn Lys Ser Leu Leu Asp Trp Tyr Thr Leu 
                805                 810                 815     


Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asp Val 
            820                 825                 830         


Lys Asn Tyr Ile Gln Tyr Leu Ser Asn Ile Asp Lys Arg Ala Gly Ser 
        835                 840                 845             


Val Lys Asn Asn Lys Ser Ala Ser Thr Glu Val Lys Ile Arg Gln Tyr 
    850                 855                 860                 


Ser Glu Ile Val Arg Ile Leu Asp Phe Ser Leu Gln Tyr Ile Gly Arg 
865                 870                 875                 880 


Val Ser Asn Asp Val Thr Asp Tyr Phe Val Asp Glu Asp Glu Tyr Ala 
                885                 890                 895     


Ala Phe Leu Ser Lys Tyr Val Glu Phe Ser Gly Asn Asp Ile Val Ser 
            900                 905                 910         


Met Lys Ala Phe Cys Gln Ser Arg Thr Ala Asn Gly Lys His Thr Ile 
        915                 920                 925             


Gly Leu Tyr Cys Asp Gly Ala Asn Pro Ile Met Asn Arg Asn Ile Ala 
    930                 935                 940                 


Tyr Ala Lys Met Tyr Gly Asn Asp Glu Ile Leu Ser Tyr Ile Tyr Asn 
945                 950                 955                 960 


Lys Val Thr Lys Lys Asp Ile Glu Lys Tyr Tyr Val Ser Gln Asp Asn 
                965                 970                 975     


Leu Glu Lys Val Phe Ala Asp Gly Lys Cys Gln Asp Val Gln Gln Gln 
            980                 985                 990         


Asn Ala Leu Cys Asp Phe Gln Lys  Met Lys Asn His Ile  Glu Leu Thr 
        995                 1000                 1005             


Glu Val  Ser Ile Tyr Thr Asp  Ile Leu Asn Asp Phe  Met Ala Gln 
    1010                 1015                 1020             


Phe Ile  Ser Trp Ala Tyr Leu  Arg Glu Arg Asp Leu  Met Tyr Phe 
    1025                 1030                 1035             


Gln Leu  Gly Leu Asn Tyr Ile  Arg Met Phe Tyr Gly  Thr Tyr Glu 
    1040                 1045                 1050             


Leu Glu  Glu Lys Tyr Tyr Lys  Leu His Gly Glu Asn  Ile Asn Ile 
    1055                 1060                 1065             


Glu Lys  Gly Ala Leu Leu Tyr  Gln Ile Val Ala Met  Tyr Ser His 
    1070                 1075                 1080             


Glu Leu  Pro Ile Tyr Lys Val  Asp Glu Ser Gly Ile  Ala Ile Leu 
    1085                 1090                 1095             


Ala Glu  Lys Gln Gly Ser Ser  Gly Ala Ser Ile Lys  Ser Phe Val 
    1100                 1105                 1110             


Thr Glu  Tyr Cys Lys Glu Glu  Met Lys Lys Ala Tyr  Thr Tyr Glu 
    1115                 1120                 1125             


Asn Gly  Leu Glu Leu Phe Glu  Asp Val Asn Gln His  Asp Asp Leu 
    1130                 1135                 1140             


Ser Lys  Leu Arg Asn Asp Phe  Ala His Met Arg Tyr  Met Ser Ala 
    1145                 1150                 1155             


Arg Asp  Lys Ser Ile Met Asp  Ile Val Ser Glu Ile  Tyr Asn Gly 
    1160                 1165                 1170             


Phe Phe  Ile Tyr Asp Thr Lys  Leu Lys Lys Ser Val  Ser Phe Ile 
    1175                 1180                 1185             


Phe Lys  Asn Ile Leu Met Arg  Tyr Ala Val Asp Val  Asn Ile Glu 
    1190                 1195                 1200             


Phe Cys  His Lys Gly Asp Asn  Glu Asp Thr Asn Asn  Leu Ile Arg 
    1205                 1210                 1215             


Ile Lys  Asp Glu Val Gly Leu  Tyr Ser Asp Lys Tyr  Thr Tyr Lys 
    1220                 1225                 1230             


Val Glu  Asp Asn Asp Thr Val  Asp Ile Glu Val Arg  Asn Ser Glu 
    1235                 1240                 1245             


Phe Leu  Glu Gln Leu Lys Lys  Leu Leu Glu Tyr Lys  Lys Glu Ser 
    1250                 1255                 1260             


Glu Gly  Ser Glu Leu 
    1265             


<210>  804
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  804

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  805
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  805

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Lys Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn Gln Ile His Thr Gly Thr Lys Pro Lys Lys Trp Glu 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Ile Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Asn Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Val Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Phe Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Gln Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Lys Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ala Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asp Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Ile Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Met Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Ile Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Leu Cys  Ala Lys Leu Cys Ile  Ser Ser Leu Lys Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Thr Leu Ile Thr Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Ser Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Gly Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asp Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  806
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  806

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  807
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  807

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  808
<211>  1678
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  808

Met Glu Asp Val Glu Gly Ala Val Tyr Pro Val Asp Leu His Ser Asp 
1               5                   10                  15      


Gly Asp Gly Glu Arg Asp His Gly Ile Ile Ser Pro Val Lys Glu Lys 
            20                  25                  30          


Val Glu Glu Thr Leu Pro Glu Phe Ile Cys Lys Gly Thr Tyr Lys Gly 
        35                  40                  45              


Val Pro Leu Cys Asp Asp Asn Lys Asn Arg Ile Arg Gly Arg Lys Gly 
    50                  55                  60                  


Lys Tyr His Leu Phe Val Leu Leu Lys Ser Asp Ala Gly Lys Lys His 
65                  70                  75                  80  


Leu Leu Ala Glu Asn Ala Asn Met Leu Val Lys Asp Asp Trp Ala Ala 
                85                  90                  95      


Asn Arg Tyr Phe His Met Ala Ser Ser Val Val Asn Arg Leu Ile Phe 
            100                 105                 110         


His Asn Pro Leu Tyr Ser Gly Gly Gln Met Pro Ala Ile Lys Leu Asp 
        115                 120                 125             


Ile Ala Thr Arg Ala Thr Gly Asp Ile Asp Lys Met Gly Asn Gly Ile 
    130                 135                 140                 


Lys Glu Glu Phe Gln Lys Gln Lys Tyr Arg Val Lys Lys Gly Asn Asn 
145                 150                 155                 160 


Arg Glu Tyr Tyr Ser Ile Met Asn Ala Asp Ile Tyr Arg Thr Leu Ile 
                165                 170                 175     


Ala Gln Glu Met Val Asn Ser Gly Lys Ile Asn Ile Arg Ile Glu Lys 
            180                 185                 190         


Leu Asn Ile Lys Ser Ile Cys Tyr Asp Ser Ser Gly Gln Gly Met Glu 
        195                 200                 205             


Phe Leu Tyr Leu Ala Asp Ser Ile Cys Ser Ile Leu Gly Tyr Arg Leu 
    210                 215                 220                 


Thr Lys Thr Gly Ser Ser Ala Asp Asp Trp Leu Val Gln Ile Lys Glu 
225                 230                 235                 240 


Arg Ile Cys Asp Leu Asn Arg Asp Asn Glu Asn Leu Ile Phe Gly Tyr 
                245                 250                 255     


Asp Glu Ile Asp Asn Tyr Phe Ser Asn Ala Trp Gly Gln Phe Glu Asn 
            260                 265                 270         


Lys Asp Met Phe Lys Ala Leu Ser Val Ile Tyr Asp Ala Lys Trp Met 
        275                 280                 285             


Lys Gly Glu Phe Ala Lys His Tyr Gln Asn Glu Trp Phe Pro Phe Leu 
    290                 295                 300                 


Glu Glu Gln Leu Arg Arg Arg Ala Thr Pro Glu Leu Phe Leu Gln Ser 
305                 310                 315                 320 


Val Asp Gln Leu His Ala Phe Leu Gln Thr Asn Asn Ile Asp Gln Glu 
                325                 330                 335     


Lys Leu Leu Tyr Ile Met Gln Gln Leu Glu Ser Met Val Glu Gly Val 
            340                 345                 350         


Ser Asn Arg Phe Lys Ser Lys Glu Ser Lys Glu Arg Ala Leu Tyr Lys 
        355                 360                 365             


Leu Tyr Asp Ala Gly Val Ala Val Tyr Cys His Ile Gly Asp Ala Thr 
    370                 375                 380                 


Lys Ala Gln Gly Tyr Tyr Glu Lys Cys Arg Leu His Val Val Tyr Val 
385                 390                 395                 400 


Ser Leu Asp Asp Tyr Met Lys Thr Asn Asn Arg Leu Ile Val Leu Leu 
                405                 410                 415     


Glu Asp Ala Phe Gln Trp Asp Glu Ala Leu Asn Lys Ala Lys Glu Asn 
            420                 425                 430         


Leu Asp Ile Leu Gln Met Ile Ala Lys Gly Ala Thr Val Ser Pro Lys 
        435                 440                 445             


Asn Phe Leu Asp Cys Leu Gln Lys Ser Ala Glu Thr Ile Lys Phe Glu 
    450                 455                 460                 


Arg Arg Lys Lys Lys Ser Gly Asn Val Val Trp Val Pro Val Lys Leu 
465                 470                 475                 480 


Glu Glu Asp Tyr Lys Lys Tyr Gly Thr Ser Leu Gln Glu Gln Val Glu 
                485                 490                 495     


Gln Ala Val His Phe Asn Ile Lys Arg Ser Leu Ser Lys Glu Thr Val 
            500                 505                 510         


Ile His Ser Val Cys Lys Ile Leu Ile Ser Phe Phe Gln Lys Asn Gln 
        515                 520                 525             


Ile Thr Leu Lys Glu Glu Glu Ser Arg Leu Leu Ile Gln Ala Leu Asp 
    530                 535                 540                 


Lys Asp Ile Arg Lys Glu Lys Gln Leu Lys Tyr Ile Glu Lys Ser Ile 
545                 550                 555                 560 


Gln Leu Gln Asn Thr Lys Val Gln Pro Val Gln Val Asp Gly Lys Thr 
                565                 570                 575     


Val Leu Ala Leu Ser Gly Ala Lys His Pro Lys Lys Lys Ile Ile Phe 
            580                 585                 590         


Asp Phe Leu Val Arg Tyr Ala Asn Ala Ser Gln Ser Asp Gln Glu Asn 
        595                 600                 605             


Met Leu Ile Gln Met Arg Lys Trp Ile Leu Leu Phe Val Cys Gly Glu 
    610                 615                 620                 


Gln Ala Tyr Lys Glu Ala Glu Glu Lys Gly Ile Ser Thr Arg Gly Phe 
625                 630                 635                 640 


Ala Ala Glu His Gly Asp Ile Pro Gly Thr Phe Gly Gly Asp Val Tyr 
                645                 650                 655     


Ser Lys Ile Ser Asp Leu Gln Glu Ile Lys Lys Gln Asp Lys Gly Ala 
            660                 665                 670         


Ser Glu Arg Leu Lys Val Ser Lys Leu Lys Lys Glu Ile Ala Ala Met 
        675                 680                 685             


Ile Asn Asp Thr Leu Thr Thr Val Tyr Arg Glu Ile Lys Gly Met Asp 
    690                 695                 700                 


Gly Val Ala Glu Glu Asp Met Phe Trp Ile Glu Tyr Ile Gln Lys Glu 
705                 710                 715                 720 


Val Gln Lys Val Leu Leu Lys Lys Asn Lys Leu Ala Thr Gly Ile Glu 
                725                 730                 735     


Tyr Lys Ile Gln Asn Lys Tyr Leu Cys Asn Gln Val Trp Lys Asn Trp 
            740                 745                 750         


Val Ser Phe Ile Ala Gly Lys Tyr Val Asp Met Gly Lys Gly Val Tyr 
        755                 760                 765             


His Phe Val Met Pro Glu Cys Asn Ser Asn Ile Asn Glu Leu Glu Val 
    770                 775                 780                 


Cys Glu Val Gln Asp Phe Tyr Lys Lys Gly Ile Ser Ser Phe Asp Tyr 
785                 790                 795                 800 


Glu Met Ile Lys Ala Glu Glu Thr Leu Glu Arg Asp Met Ala Val Ala 
                805                 810                 815     


Val Thr Phe Ala Val Asn Asn Phe Ser Arg Ala Ile Ile Lys Lys Glu 
            820                 825                 830         


Ser Glu Arg Thr Thr Ser Gln Asn Glu Asp Val Leu Gln Tyr Thr Glu 
        835                 840                 845             


Lys Glu Phe Glu Lys Tyr Cys Asp Gly Glu Asn Ile His Lys Asn Ile 
    850                 855                 860                 


Leu Gln Tyr Phe Gly Gly Ile Ser Lys Trp Glu Asp Cys Glu Ile Val 
865                 870                 875                 880 


His Ala Ser Gly Phe Glu Val Phe Asp Thr Ile Lys Lys Asn Ile Asn 
                885                 890                 895     


Cys Val Arg Asn Ala Ser Tyr His Tyr Ser Gln Asn Leu Glu Lys Arg 
            900                 905                 910         


Glu Val Arg Asn Lys Tyr Val Asp Met Leu Cys Arg His Glu Val Asp 
        915                 920                 925             


Asn Tyr Thr Glu Ile Ile Lys Asp Lys Tyr Tyr Ser Asn Asn Leu Tyr 
    930                 935                 940                 


Arg Phe Tyr Pro Glu Ser Thr Leu Lys Arg Leu Met Asp Glu Leu Tyr 
945                 950                 955                 960 


Ser Glu Val Lys Glu Arg Pro Ala Gln Ile Pro Ala Phe Asn Arg Ile 
                965                 970                 975     


Ile Asn Lys Gln Lys Ile Ala Ala Phe Leu Ser Thr Val Ile Lys Gly 
            980                 985                 990         


Asn Lys Leu Lys Lys Val Ile Gly  Asn Val Glu Asp Ala  Ser Leu Phe 
        995                 1000                 1005             


Tyr Pro  Ala Met Ile Phe Leu  Leu Lys Glu Ile Tyr  Tyr Asn Ala 
    1010                 1015                 1020             


Phe Ile  Cys Asn Glu Asn Cys  Lys Lys Trp Val Glu  Glu Ala Ala 
    1025                 1030                 1035             


Leu Lys  Asn Ala Glu Asn Glu  Lys Asp Lys Asn Lys  Lys Glu Ala 
    1040                 1045                 1050             


Asn Lys  Asn Phe Ile Leu Arg  Leu Glu Gln Leu His  Thr Glu Ser 
    1055                 1060                 1065             


Phe Gly  Asp Met Cys Gln Gln  Leu Met Thr Ala Leu  Asp Leu Gln 
    1070                 1075                 1080             


Asn Asn  Arg Asp His Arg Val  Asn Thr Asn Ala Asp  Gln Leu Lys 
    1085                 1090                 1095             


Tyr Lys  His Phe Arg Ile Leu  Leu Tyr Asn Ala Ile  Tyr Glu Ala 
    1100                 1105                 1110             


Phe Ala  Asn Phe Ile Lys Ser  Lys Glu Gln Lys Leu  Tyr Ser Leu 
    1115                 1120                 1125             


Tyr Asp  Ala Val Arg Glu Pro  Val Leu Gln Thr Asn  Leu Lys Thr 
    1130                 1135                 1140             


Arg Glu  Glu Phe Leu Ser Gly  Trp Thr Ala His Arg  Tyr Asp Thr 
    1145                 1150                 1155             


Lys Ile  Asp Lys Ile Thr Gly  Asn Ser Ile Leu Ser  Ala Trp Tyr 
    1160                 1165                 1170             


Val Thr  Ser His Phe Leu Ala  Pro Arg Gln Val Asn  His Leu Ala 
    1175                 1180                 1185             


Gly Ser  Met Lys Asn Tyr Arg  Gln Phe Val Asn Asp  Ile Gly Asp 
    1190                 1195                 1200             


Arg Arg  Asn Lys Val Glu Ser  Lys Gln Ser Tyr Arg  Lys Thr Glu 
    1205                 1210                 1215             


Ile Tyr  Glu Asp Val Val Met  Val Leu Glu Leu Val  Asp Ala Ser 
    1220                 1225                 1230             


Ser Gly  Gln Ile Ser Asn Glu  Val Lys Asp Tyr Phe  Gly Ser Asp 
    1235                 1240                 1245             


Glu Glu  Tyr Ala Arg His Leu  Ser Lys Tyr Val Asp  Phe Ser Asp 
    1250                 1255                 1260             


Glu Lys  Ala Lys Asn Asn Met  Glu Glu Pro Ser Cys  Arg Met Leu 
    1265                 1270                 1275             


Leu Gln  Leu Phe Ser Glu Asn  Arg Gln Gln Thr Gly  Asp Gly Asp 
    1280                 1285                 1290             


Met Ile  Asp Ile Tyr Tyr Lys  Asn Asn Val Ile Leu  Asn Arg Asn 
    1295                 1300                 1305             


Ile Val  Leu Ser Lys Met Tyr  Gly Leu Asp Ile Cys  Glu Asn Gly 
    1310                 1315                 1320             


Trp Trp  Gln Lys Val Thr Leu  Glu Asn Asp Ile Leu  Asn Tyr Tyr 
    1325                 1330                 1335             


Lys Leu  Lys Arg Glu Leu Ser  Ser Gly Ser Lys Phe  Thr Gly Thr 
    1340                 1345                 1350             


Ala Val  Phe Glu Lys Gly Arg  Cys Glu Phe Pro Glu  Glu Gln Glu 
    1355                 1360                 1365             


Lys Leu  Lys Lys Phe Gln Asn  Ile Lys Asn Arg Val  Glu Leu Leu 
    1370                 1375                 1380             


Asp Val  Met Thr Tyr Glu Glu  Ile Leu Ile Asp Leu  Tyr Ser Gln 
    1385                 1390                 1395             


Leu Val  Ser Trp Ala Tyr Met  Arg Glu Arg Asp Leu  Leu Tyr Met 
    1400                 1405                 1410             


Gln Leu  Gly Val Ala Tyr Leu  Ala Leu Asn Tyr Gly  Asp Lys Ser 
    1415                 1420                 1425             


Tyr Arg  Thr Arg Ser Arg Glu  Met Phe Gly Asp Asp  Arg Leu Asn 
    1430                 1435                 1440             


Ser Met  Glu Gly Pro Gly Pro  Val Asn Ile Lys Asn  Gly Ala Leu 
    1445                 1450                 1455             


Leu Tyr  Gln Leu Ile Ala Met  Asn Asn Pro Cys Met  Thr Leu Tyr 
    1460                 1465                 1470             


Glu Val  Glu Asn Gly Lys Ala  Thr Pro Ala Lys Lys  Ala Gly Asn 
    1475                 1480                 1485             


Ser Ile  Gly Ala Arg Val Gly  Cys Leu Tyr Lys Gly  Tyr Leu Asn 
    1490                 1495                 1500             


Cys Arg  Glu Glu Val Tyr Lys  Asn Gly Leu Tyr Phe  Phe Glu Asn 
    1505                 1510                 1515             


Tyr Gln  Leu His Asp Tyr Ile  Val Lys His Val Arg  Asn Glu Ile 
    1520                 1525                 1530             


Asp His  Phe Lys Tyr Phe Arg  Lys Pro Val Lys Ser  Leu Leu Glu 
    1535                 1540                 1545             


Leu Tyr  Ser Glu Ile Tyr Thr  Tyr Phe Phe Thr Tyr  Asp Lys Lys 
    1550                 1555                 1560             


Leu Gln  Lys Ser Val Thr Phe  Ile Leu Leu Asn Ile  Leu Glu Lys 
    1565                 1570                 1575             


Tyr Phe  Val Arg Ala Lys Ile  Gln Met Gly Tyr Lys  Lys Val Glu 
    1580                 1585                 1590             


Val Lys  Asn Asp Lys Lys Glu  Met Ile Pro Val Ile  Glu Thr Asp 
    1595                 1600                 1605             


Ile Asn  Ile Glu Lys Ala His  Ser Leu Tyr Met Phe  Tyr Asn Gln 
    1610                 1615                 1620             


Ile Lys  Tyr Arg Glu Gln Asp  Ser Lys Glu Asp Lys  Lys Ala Tyr 
    1625                 1630                 1635             


Asn Asp  Tyr Lys Ser Arg Tyr  Asp Leu Asp Ile Gly  Lys Gly Val 
    1640                 1645                 1650             


Leu Lys  Leu Glu Ala Arg Asp  Asp Leu Phe Val Lys  Gln Leu Leu 
    1655                 1660                 1665             


Glu Leu  Leu Ser Tyr Lys Glu  Ser Met Arg 
    1670                 1675             


<210>  809
<211>  1366
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  809

Met Lys Leu Ser Lys Glu Asn His Ile Arg Ser Ala Val Val Ile Ser 
1               5                   10                  15      


Gly Lys Glu Gly Asn Ile Ala Gly Thr Leu Tyr Lys Ile Pro Gly Glu 
            20                  25                  30          


Gly Thr Val Asp Leu Lys Lys Arg Met Leu Glu Arg Asp Lys Ala Val 
        35                  40                  45              


Lys Ser Leu Tyr Asn Ile Phe Asn Gln Ile Gln Leu Gly Asn Glu Pro 
    50                  55                  60                  


Lys Glu Trp Lys Glu Asn Arg Asn Leu Ser Thr Glu Glu Asn Thr Arg 
65                  70                  75                  80  


Arg Met His Gln Lys Lys Val Lys Ile Gln Asn Tyr Lys Met Lys Lys 
                85                  90                  95      


Ala Cys Ser Arg Tyr Val Asn Thr Ile Ser Arg Thr Ile Asn Glu Leu 
            100                 105                 110         


Leu Phe Phe Tyr Lys Thr Thr Lys Thr Thr Gln Asn Asn Lys Val Lys 
        115                 120                 125             


Tyr Asp Lys Leu Lys Met Met His Lys Asn Glu Asp Ile Ile Ser Lys 
    130                 135                 140                 


Met Lys Asn Glu Asn Ile Leu Gln Gln Phe Lys Val Glu Gly Lys Asn 
145                 150                 155                 160 


Gly Lys Leu Glu Lys Gly Lys Leu Glu Asp Phe Val Thr Leu Ala Leu 
                165                 170                 175     


Arg Ser Ser Leu Val Val Ser Arg Tyr Lys Gly Lys Asp Phe Asp Ser 
            180                 185                 190         


Val Ala Ala Val Ala Val Phe Leu Glu Asn Ile Gly Asn Asn Asn Ile 
        195                 200                 205             


Ser His Glu Asp Glu Arg Thr Ile Asn Ile Leu Leu Asp Leu Ile Arg 
    210                 215                 220                 


Glu Asp Phe Thr Lys Leu Asn Pro Asn Ile Asp Asn Thr Met Gly Ala 
225                 230                 235                 240 


Arg Leu Ile Arg Ser Val Thr Asn Gln Asn Met Leu Val Gln Pro Gln 
                245                 250                 255     


Asn Asp Arg Phe Ser Phe Pro Cys Val His Asp Ser Gly Lys Ser Lys 
            260                 265                 270         


Val Ser Asn Lys Asn Val Glu Lys Ser Gly Leu Asp Asn Phe Leu Leu 
        275                 280                 285             


Asp Tyr Ala Asn Leu Asp Lys Asp Ile Arg Glu Asn Tyr Leu Arg Lys 
    290                 295                 300                 


Leu Arg Arg Ile Ile Asp Ile Tyr Phe Ser Ala Pro Ile Thr Tyr Gln 
305                 310                 315                 320 


Lys Asp Met Asp Val Ala Leu Ser Glu Val Val Val Lys Asp Lys Phe 
                325                 330                 335     


Asp Val Trp Lys Lys His Asn Glu Gly Lys Lys Asp Ser Asn Thr Phe 
            340                 345                 350         


Val Lys Val Pro Glu Val Leu Ile Lys Ala Glu Arg Asp His Glu Lys 
        355                 360                 365             


Leu Asp Thr Val Ile Glu Lys Gln Ala Arg Lys Glu Leu Ala Asp Arg 
    370                 375                 380                 


Val Arg Lys Gln Asn Met Thr Cys Tyr Arg Tyr Thr Gln Ala Val Val 
385                 390                 395                 400 


Lys Lys Tyr Asn Ala Lys Glu Ala Leu Phe Phe Glu Asn Asp Asp Ile 
                405                 410                 415     


Asn Gln Tyr Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu 
            420                 425                 430         


Lys Ser Cys Lys Ile Gly Thr Leu Phe Lys Leu His Asn Gly Tyr Leu 
        435                 440                 445             


Ile Glu Lys Val Trp Lys Asp Val Ile Asn Leu Ile Ser Ile Lys Tyr 
    450                 455                 460                 


Ile Ala Leu Gly Lys Val Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp 
465                 470                 475                 480 


Asn Asp Asn Lys Val Lys Arg Leu Gly Asp Ile Ser Glu Lys Ile Arg 
                485                 490                 495     


Ser Gly Ile Thr Ser Phe Asp Tyr Glu Met Leu Lys Ala Gln Glu Thr 
            500                 505                 510         


Leu Gln Arg Glu Leu Ala Val Asn Val Ala Phe Ser Ala Asn Asn Leu 
        515                 520                 525             


Ala Arg Ala Val Cys Asn Met Ser Asp Leu Ser Asp Lys Thr Ser Asp 
    530                 535                 540                 


Phe Leu Leu Trp Gln Pro Asp Asp Ile Asn Asn Lys Met Lys Lys Ser 
545                 550                 555                 560 


Thr Gly Asn Asp Glu Asn Asn Glu Lys Asn Lys Arg Ala Val Cys Ala 
                565                 570                 575     


Val Leu Gln Phe Phe Gly Gly Lys Ser Leu Trp Asn Val Val Asp Phe 
            580                 585                 590         


Glu Lys Ala Tyr Lys Asn Ala Gly Lys His Gly Tyr Gly Val Tyr Phe 
        595                 600                 605             


Ile Asn Asp Leu Arg Lys Ala Ile Phe Ala Ala Arg Asn Glu Ser Phe 
    610                 615                 620                 


His Phe Lys Thr Ala Ser Val Asn Asn Glu Lys Trp Asp Val Glu Phe 
625                 630                 635                 640 


Leu Gly Arg Met Phe Glu Lys Glu Thr Glu Phe Cys Leu Asp Ile Glu 
                645                 650                 655     


Lys Glu Arg Phe Tyr Ser Asn Asn Leu Pro Met Phe Tyr Lys Ser Ser 
            660                 665                 670         


Asn Leu Glu Lys Met Leu Asn His Phe Tyr Ser Lys Asn Ile Ser Arg 
        675                 680                 685             


Thr Ala Gln Val Leu Ser Tyr Asn Thr Val Phe Val Arg Lys Thr Phe 
    690                 695                 700                 


Pro Glu Tyr Leu Asn Asn Val Leu Lys Tyr Lys Lys Pro Gly Thr Asp 
705                 710                 715                 720 


Ala Glu Ile Leu Asp Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu Leu Lys 
                725                 730                 735     


Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Lys Asp Ala Phe Lys Tyr 
            740                 745                 750         


Phe Glu Asn Ala Val Tyr Asn Leu Asn Ser Lys Asn Ile Asn His Asp 
        755                 760                 765             


Ser Leu Gly Lys Lys Leu Asn Arg Asp Glu Met Lys Arg Lys Lys Ala 
    770                 775                 780                 


Ala Glu Ser Phe Gln Arg Arg Phe Val Glu Ile Lys Arg Val Ser Asp 
785                 790                 795                 800 


Ser Ser Ile Ser Tyr Val Cys Gln Val Phe Met Thr Asp Tyr Asn Gln 
                805                 810                 815     


Gln Asn Asn Gln Asn Lys Lys Val Arg Ser Ser Asn Asp Ser Leu Leu 
            820                 825                 830         


Asp Lys Pro Ile Tyr Gln His Phe Lys Met Leu Leu Lys Glu Thr Ile 
        835                 840                 845             


Lys Ser Ala Phe Ala Ala Tyr Leu Lys Asp Asn Asn Asn Lys Asp Leu 
    850                 855                 860                 


Phe Gly Phe Ile Gly Glu Pro Leu Lys Ile Asn Lys Asn Asp Asp Val 
865                 870                 875                 880 


Lys Val Ile Lys Lys Glu Glu Phe Leu Pro Asp Trp Lys Ser Glu Lys 
                885                 890                 895     


Tyr Ser Leu Leu Ile Glu Lys Val Lys Lys Ser Pro Lys Leu Gln Met 
            900                 905                 910         


Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met 
        915                 920                 925             


Ala Gly Ser Met Arg Ser Tyr Leu Gln Tyr Val Ser Asp Ile Asn Lys 
    930                 935                 940                 


Arg Ala Asn Val Met Gly Ser Lys Leu His Val Glu Val Leu Asp Lys 
945                 950                 955                 960 


Asp Thr Val Lys Asp Trp Ile Gln Val Ile Glu Val Cys Leu Leu Leu 
                965                 970                 975     


Ala Ser Arg Thr Ser Asn Gln Phe Asp Asp Tyr Phe Asn Asp Gly Asp 
            980                 985                 990         


Asp Tyr Ala Gly Tyr Leu Lys Ser  Tyr Val Asp Phe Ser  Asp Glu Asn 
        995                 1000                 1005             


Met Pro  Ser Ala Tyr Ser Ala  Leu Val Tyr Phe Ser  Asp Gln Gly 
    1010                 1015                 1020             


Lys Ile  Asp Leu Tyr Val Asp  Pro Lys Asn Pro Lys  Ile Asn Arg 
    1025                 1030                 1035             


Asn Ile  Val Gln Ser Lys Leu  Phe Ala Ala Asp His  Ile Leu Gly 
    1040                 1045                 1050             


Asn Gly  Arg Ile Val Gln Pro  Val Ser Lys Asp Asp  Ile Val Glu 
    1055                 1060                 1065             


Phe Tyr  Asn Leu Lys Ala Lys  Ile Ala Asp Ser Lys  Ile Lys Gly 
    1070                 1075                 1080             


Glu Asn  Ile Ser Glu Lys Glu  Gln Arg Asn Ile Ile  Arg Tyr Gln 
    1085                 1090                 1095             


Arg Leu  Lys Asn Lys Val Glu  Leu Arg Asp Ile Val  Glu Tyr Gly 
    1100                 1105                 1110             


Glu Ile  Ile Asn Glu Leu Leu  Gly Gln Leu Ile Asn  Trp Ser Phe 
    1115                 1120                 1125             


Met Arg  Glu Arg Asp Leu Leu  Tyr Phe Gln Leu Gly  Phe His Tyr 
    1130                 1135                 1140             


Asn Cys  Leu Arg Asn Asn Ser  Glu Lys Pro Glu Glu  Tyr Lys Arg 
    1145                 1150                 1155             


Ile Glu  Ala Asp Asp Ile Ser  Ile Asn Asp Ala Val  Leu Tyr Gln 
    1160                 1165                 1170             


Ile Ile  Gly Met Tyr Val Asn  Gly Ile Pro Val Tyr  Thr Ser Asp 
    1175                 1180                 1185             


Asn Asn  Lys Leu Lys Gly Lys  Cys Val Asn Gly Gly  Ala Gly Gly 
    1190                 1195                 1200             


Lys Ile  Ala Ala Val Cys Glu  Tyr Ser Glu Tyr Leu  Gly Phe Lys 
    1205                 1210                 1215             


Lys Ala  Thr Leu Tyr Glu Ser  Gly Leu Glu Val Phe  Glu Val Leu 
    1220                 1225                 1230             


Ala Glu  His Asp Asp Ile Ile  Lys Leu Arg Asn Gly  Ile Glu His 
    1235                 1240                 1245             


Phe Lys  Tyr Tyr Leu Gly Asn  Tyr Arg Ser Ile Met  Ser Leu Tyr 
    1250                 1255                 1260             


Ser Glu  Val Phe Asp Arg Phe  Phe Thr Tyr Asp Leu  Lys Tyr Gln 
    1265                 1270                 1275             


Lys Asn  Val Leu Asn Leu Leu  Gln Asn Ile Leu Leu  Arg His Asn 
    1280                 1285                 1290             


Ile Val  Ile Val Pro Glu Phe  Glu Ser Gly Thr Lys  Lys Val Gly 
    1295                 1300                 1305             


Lys Asn  Ile Lys Gln Ala Ala  Lys Ile Ser Ile Lys  Asn Ile Gln 
    1310                 1315                 1320             


Ser Asp  Lys Phe Thr Tyr Lys  Ile Lys Gly Gly Thr  Ala Ser Ile 
    1325                 1330                 1335             


Asp Ala  Lys Asp Asp Arg Tyr  Leu Glu Thr Ile Lys  Lys Ile Leu 
    1340                 1345                 1350             


Tyr Tyr  Pro Glu Tyr Asp Lys  Asp Ser Gly Gly Val  Cys 
    1355                 1360                 1365     


<210>  810
<211>  1380
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  810

Met Lys Leu Ser Lys Glu Lys Gln Ile Arg Ser Ala Val Ala Asn Lys 
1               5                   10                  15      


Glu Lys Asn Thr Glu Gly Val Leu Tyr Arg Phe Pro Gly Asp Asp Ile 
            20                  25                  30          


Gly Gly Val Gln Ala Gln Met Leu Val Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Leu Gly Asn Lys Pro Lys Glu 
    50                  55                  60                  


Trp Met Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Lys Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Ala Ile Asn Asp Ile Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Lys Glu Ala Asp Lys Lys Ile Arg Asn Met Ser Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Asn Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Ser Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Gly Asn Gln Glu Phe Asp Ser Ile Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Asp Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Ser Ile Gln Asp Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Ile Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Glu Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Asp Gly Leu Asn Glu Phe Met Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Glu Glu Lys Arg Ala Glu Val Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Ser His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Val Asn Lys Gly Lys Phe Tyr Val Trp 
305                 310                 315                 320 


Lys Lys His Glu Cys Gly Lys Lys Glu Asn Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Val Glu Ala Glu Ala Glu Ser Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Ile Phe Phe Glu Asn Asp Thr Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Thr Gly Thr Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Lys Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asn Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Gln Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Leu 
            660                 665                 670         


Val Arg Thr Val Phe Pro Glu Tyr Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Asn Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Arg Thr Leu Arg Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Lys 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Glu Asn Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Cys Ala Gln Asp 
            900                 905                 910         


Ile Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu 
        915                 920                 925             


Leu Ser Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Lys Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Lys Phe Ser Glu Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Thr Asn Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Gly  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Glu Lys Pro Glu  Glu Tyr Glu Lys Ile  Glu Ala Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Ile  Tyr Ala Pro Glu Lys  Asn Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Gln Gly Arg Val Gly  Ala Lys Val 
    1145                 1150                 1155             


Thr Ser  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Glu Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Met Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Val Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Val Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Glu Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asn Ala 
    1280                 1285                 1290             


Lys Asp  Lys Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Asp  Ala Glu Asp Ala Asp  Ser Lys Lys Pro Val  Ile Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Glu  Asp Glu Asp 
    1325                 1330                 1335             


Lys Gln  Lys Gly Lys Glu Asn  Arg Gly Lys Lys Asn  Thr Glu Thr 
    1340                 1345                 1350             


Arg Ser  Asp Ala Glu Lys Asn  Asn Asn Glu Arg Leu  Ser Tyr Asn 
    1355                 1360                 1365             


Pro Phe  Ala Asn Phe Asp Phe  Lys Leu Pro Asn Lys  
    1370                 1375                 1380 


<210>  811
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  811

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Ile Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Leu Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Glu 
        755                 760                 765             


Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Arg Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Asp Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Ile Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1400                 1405                 1410         


<210>  812
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  812

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Ile Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Leu Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Glu 
        755                 760                 765             


Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Arg Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Asp Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Ile Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1400                 1405                 1410         


<210>  813
<211>  1287
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  813

Met Arg Ile Gly Lys Val Gln Gly Arg Thr Phe Thr Gly Phe Asp Asn 
1               5                   10                  15      


Ala Arg Gly Lys Thr Leu Arg Arg Arg Leu Leu Thr Arg Pro Asp Asn 
            20                  25                  30          


Glu Ala Arg Ser Leu Ser Glu His Leu Ala His Asp Pro Lys Ala Leu 
        35                  40                  45              


Ile Gly Gln Ala Ile Ser Arg Ile Asp Thr Ile Tyr Gln Lys Pro Lys 
    50                  55                  60                  


Thr Gly Lys Pro Thr Pro Glu Gln Phe Gly His Arg Asp Thr Leu Gly 
65                  70                  75                  80  


Trp Ala Tyr Trp Lys Leu Leu Val Ala Ser Tyr Pro Glu Val Glu Gly 
                85                  90                  95      


His Arg Asp Leu Phe Val Arg Arg Leu His Pro Tyr Gly Asp Thr Pro 
            100                 105                 110         


Pro Lys Ser His Gly Gln Lys Glu Gly Glu His Gln Lys Gly Gly Lys 
        115                 120                 125             


Pro Gln Leu Glu Gly Arg Trp His Gly Val Met Ala Gln His Gly Lys 
    130                 135                 140                 


Asn Pro Asp Gln Ile Ala Ala Arg Leu Phe Asp His Leu His Asn Ser 
145                 150                 155                 160 


Glu Leu Arg Phe Gly Gly Thr Ala Ser Gly Glu Pro Arg Thr Arg Pro 
                165                 170                 175     


Gly Lys Glu Ala Thr Pro Thr Gly Leu Ile Gly Ala Arg Ala Lys Thr 
            180                 185                 190         


Ile Glu His Ser Val Leu Pro Arg Asp Ala Lys Arg Phe Val Ala Glu 
        195                 200                 205             


Trp Arg Gly Glu Asp Gln Glu Arg Tyr Ala Gly Ala Arg Asp Ile Ala 
    210                 215                 220                 


Ala Ala Ile Ser Ala Gly Leu Asn Asp Lys Asp Gln Lys Ser Gly Ser 
225                 230                 235                 240 


Gly Arg Lys Ser Ala Val Ile Gly Lys Leu Leu Ser Asp His Leu Glu 
                245                 250                 255     


Thr Leu Thr Gly Asn Arg Lys Cys Arg Phe Asp Pro Lys Ser Thr Ala 
            260                 265                 270         


Glu Thr Leu Glu Leu Arg Asp Gly Glu Ser Val Asp Asp Arg Arg Arg 
        275                 280                 285             


Ile Leu Glu Leu His Ala Glu Val Lys Ala Thr Tyr Lys Arg Met Ala 
    290                 295                 300                 


Ala Trp Lys Pro Ala Lys Leu Pro Arg Asn Ser Asp Glu Leu Phe Arg 
305                 310                 315                 320 


Leu Val Arg Gln Gln Ala Asp Asn Arg Ile Leu Asn His Leu Val Arg 
                325                 330                 335     


Val Gly Arg Ile Ser Val Tyr Ser Glu Gln Ser Asp Ala Leu Ser Glu 
            340                 345                 350         


Ser Gln Phe Trp Thr Ser Gly Gly Gln Thr Gln Ile Lys Glu Ser Glu 
        355                 360                 365             


Val Phe Ala Arg Leu Trp Ile Gly Ala Ile Ser Arg Ala Ser Tyr Ser 
    370                 375                 380                 


Met Lys Ala Trp Leu Glu Pro Glu Gly Thr Val Phe Asn Pro Ser Ile 
385                 390                 395                 400 


Asn Asp Phe Asp Val Thr Ser Ser His Asn Thr Asn Arg Ile Leu Glu 
                405                 410                 415     


Asp Ser Gly Arg Leu Ser Asn Ala Met Ala Arg Arg Ala Ile Tyr Phe 
            420                 425                 430         


Gly Glu Thr Pro Glu Phe Asp Ala Leu Gly Glu Glu Asp Gln Arg Val 
        435                 440                 445             


Leu Val Lys Lys Cys Leu Asp Ala Leu Ser Ala Cys Arg Asn Arg Thr 
    450                 455                 460                 


Phe His His Gly Gln Arg Ala Lys Phe Leu Lys Glu Val Arg Lys Gly 
465                 470                 475                 480 


Leu Lys Glu Lys Glu Ala Asp Ser Ala Gly Pro Ala Ala Trp Glu Gly 
                485                 490                 495     


Ile Arg Glu Val Ile Gln Ala Asp Ala Arg Asn Leu Gly Ala Arg Leu 
            500                 505                 510         


Leu Gln Asp Leu Thr Gly Ala Lys Val His Ser Phe Ala Thr Asp Pro 
        515                 520                 525             


Glu Phe Arg His Leu Tyr Glu Ser Val Ala Ala Thr Leu Thr Ala Gly 
    530                 535                 540                 


Gly Glu Leu Glu Ala Ala Leu Pro Arg Leu Lys Asn Val Leu Lys Arg 
545                 550                 555                 560 


Ala Glu Gly Val Arg Cys Tyr Leu Asp Thr Pro Ser Gln Arg Arg Glu 
                565                 570                 575     


Gly Asp Glu Ser Leu Ile Ala Arg Leu Pro Val Ala Pro Val Pro Arg 
            580                 585                 590         


Glu Leu Asp Asp Ala Ala Thr Lys Ala Arg His Ser Ala Leu Leu Arg 
        595                 600                 605             


Leu Tyr Asp Gly Pro Phe Arg Pro Trp Ala Thr Glu Leu Arg Gly Glu 
    610                 615                 620                 


Arg Leu Ser Asp Tyr Ala Ala Arg Ala Lys Arg Leu Ala Thr Arg Leu 
625                 630                 635                 640 


Ala Lys Ser Thr Asn Thr Ala Ser Pro Tyr Pro Asp Ser Val Glu Gly 
                645                 650                 655     


Arg Ser Val Arg Leu Arg Asp Pro Ile Thr Ala Asp Thr Ala Pro Glu 
            660                 665                 670         


Thr Leu Lys Thr Tyr Leu Ser Ala Leu Thr Ala Glu Thr Ala Thr Glu 
        675                 680                 685             


Phe Arg Val Gln Lys Gly Tyr Glu Ser Asp Gly Glu Lys Ala Lys Glu 
    690                 695                 700                 


Gln Ala Glu Phe Ile Glu Asp Phe Arg Arg Asp Met Ile Ala Leu Ala 
705                 710                 715                 720 


Phe Gln Asp Phe Ile Arg Asp His Gly Phe Ala Trp Leu Leu Asp Ile 
                725                 730                 735     


Ala Ser Lys Ala Glu Pro Ser Asn Asp Ala Pro Asn Leu Pro Asp Pro 
            740                 745                 750         


Val Asp Thr Gly Lys Asp Thr Val Phe Glu Asp Trp Gln Ala Leu Leu 
        755                 760                 765             


Tyr Leu Phe Leu His Phe Val Pro Ala Asp Asp Val Ser Gln Leu Leu 
    770                 775                 780                 


His Gln Leu Arg Lys Trp Asp Ala Leu Gln Asp Lys Tyr Glu Leu Ala 
785                 790                 795                 800 


Glu Pro Gly Glu Thr Leu Gly Gln Thr Lys Ala Asp Thr Arg Lys Ile 
                805                 810                 815     


Val Gly Gln Phe Arg Asp Cys Leu Thr Leu Phe Leu Lys Thr Gly Asp 
            820                 825                 830         


Ala Arg Phe Asp Gly Glu Gly Val Glu Leu Pro Leu Ser Asp Phe Gln 
        835                 840                 845             


Glu Leu Phe Glu Ser Pro Ala Thr Phe Lys Glu Leu Phe Leu Ala Glu 
    850                 855                 860                 


Pro Ala Glu Asn Asp Ala Ser Glu Thr Asp Asp Gln Asp Ala Pro Gly 
865                 870                 875                 880 


Glu Lys His Arg Val Thr Arg Thr Arg Arg Gly Leu Arg Gln Ile Leu 
                885                 890                 895     


Arg Tyr Asn His Met Pro Val Leu Arg Asp Leu Phe Leu Ala His Lys 
            900                 905                 910         


Val Thr Asp Ala Glu Val Asp Gly Leu Gln Ala Leu Glu Val Asp Asp 
        915                 920                 925             


Pro Gln Thr Gly Glu Ser Gln Ile Gly Ala Ala Gln Arg Ile Arg Thr 
    930                 935                 940                 


Glu Ile His His His Thr Ser Asn Asp Lys Gln Ile Ser Glu Ala Lys 
945                 950                 955                 960 


Val Glu Glu Tyr Arg Arg Ala Leu Ser Thr Ile Glu Arg His Arg Phe 
                965                 970                 975     


Leu Val Gly Arg Val Tyr Leu Gly Asp His Ile Arg Val His Lys Leu 
            980                 985                 990         


Met Met Asp Val Met Gly Arg Leu  Val Asp Phe Ala Gly  Ala Trp Glu 
        995                 1000                 1005             


Arg Glu  Ala Ala Asp Gly Asp  Arg Lys Gly Phe Ile  Ser Arg Ala 
    1010                 1015                 1020             


Ile Ala  Leu Pro Glu Val Ala  Glu Gly Tyr Ala Ala  Asp Arg Leu 
    1025                 1030                 1035             


Lys Thr  Val Ala Arg Arg Val  Leu Asp Asp Gly Glu  Ala Arg Arg 
    1040                 1045                 1050             


Ile Arg  Asn Asp Leu Gly His  Phe Asn Asp Leu Ala  Pro Thr Ser 
    1055                 1060                 1065             


Gly Pro  Ala Asn Leu Thr Phe  Val Val Asn Arg Ala  Arg Arg Met 
    1070                 1075                 1080             


Met Arg  His Asp Arg Lys Arg  Lys Asn Ala Val Thr  Lys Ser Val 
    1085                 1090                 1095             


Ile Glu  Ile Leu Asn Arg Gln  Gly Leu Gly Ile Glu  Trp Thr Met 
    1100                 1105                 1110             


Arg Asn  His Glu Leu Cys Glu  Ala Lys Leu Trp Gln  Asn Pro Val 
    1115                 1120                 1125             


Lys His  Leu Gly Phe Ala Thr  Leu Glu Gly Arg Gly  Lys Lys Trp 
    1130                 1135                 1140             


Arg Arg  Pro Phe Glu Ala Arg  Tyr Gly Asp Ala Tyr  Met Ala Met 
    1145                 1150                 1155             


Val Ala  Gln Leu Phe Asp Gly  Thr Val Thr Ser Pro  Pro Ala Lys 
    1160                 1165                 1170             


Gly Pro  Pro Gln Ser Gly Lys  Ser Gly Gly Lys Pro  Gly Lys Gly 
    1175                 1180                 1185             


Ala Glu  Gly Gly Ala Lys Glu  Lys Ser Arg Ser Pro  Thr Arg Met 
    1190                 1195                 1200             


Glu Glu  Gly Gly Val Tyr Glu  Gly Arg Val Ala Lys  Ala Lys Ser 
    1205                 1210                 1215             


Asp Lys  Gly Phe Gly Phe Leu  Leu Val Glu Gly Ala  Gln Glu Glu 
    1220                 1225                 1230             


Ile Phe  Leu His Ile Tyr Gly  Ile Ser Gly Asn Arg  Pro Ala Arg 
    1235                 1240                 1245             


Ile Glu  Asn Gly Gln Arg Tyr  Arg Phe Thr Leu Gly  Ile Asp Arg 
    1250                 1255                 1260             


Asp Arg  Glu Arg Arg Lys Glu  Arg Ala Trp Val Ala  Arg Glu Ala 
    1265                 1270                 1275             


Val Arg  Ile Asp Glu Asn Arg  Ser Lys 
    1280                 1285         


<210>  814
<211>  1373
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  814

Met Ala Lys His Leu Arg Pro Ile Gly Glu Ser Tyr Thr Asp Phe Leu 
1               5                   10                  15      


Asp Glu Thr Glu Phe Val Arg Leu Gly Arg Gly Leu His Arg Gly His 
            20                  25                  30          


His Gly Val Gln Ile Pro Pro Thr Glu Leu Pro Ser Tyr Leu Ala Glu 
        35                  40                  45              


Tyr Arg Lys Ala Leu Met Arg Gln Val Val Ala Val Leu Asp Lys Val 
    50                  55                  60                  


Val Gly Lys Arg Arg Arg Leu Ser Gly Met His Pro Glu Ala Tyr Arg 
65                  70                  75                  80  


Asp Arg Val His Leu Ala Glu Ala Leu Trp Val Arg Leu Val Ala Arg 
                85                  90                  95      


Val Lys Glu Ile Gly Thr Pro Pro Asp Pro Ser Glu Leu Leu Asp Leu 
            100                 105                 110         


Arg Arg Met Trp Asn Ala Lys Ala His Pro Tyr Ala Glu Tyr Asp Val 
        115                 120                 125             


Val Pro Arg Ala Pro Leu Asn Asp Gly Asn Gly Gln Lys Ile Leu Glu 
    130                 135                 140                 


Cys Arg Glu Val Asp Asp Pro Lys Ile Glu Arg Ser Asp Phe Glu Gly 
145                 150                 155                 160 


Arg Trp His Gly Arg Phe Trp Gln Ser Glu Pro Gly Pro Val Asp Tyr 
                165                 170                 175     


Asn Ala Ile Ala Asp Arg Ile Phe Ala His Leu Phe Asp Gln Glu Ala 
            180                 185                 190         


Val Ile Gly Gly Gly Pro Arg Arg Glu Gly Asn Val Thr Val Pro Asp 
        195                 200                 205             


Glu Asp Ile Asn Gly Gln Pro Gly Pro Ala Thr Gly Lys Gly Leu Ile 
    210                 215                 220                 


Ile Ala Arg Gly Gln Ser Ile Val Lys Ser Ala Ser Asp Pro Arg Arg 
225                 230                 235                 240 


Ser Ser Lys Lys Val Gln Arg Thr Trp Asp Lys Ala Val Glu Arg Arg 
                245                 250                 255     


Tyr Phe Gly Asp Asp Gly Lys Gly Gly Ser Asp Ile Ala Lys Ala Ile 
            260                 265                 270         


Tyr Glu Glu Leu Gly Asp Pro Ala Thr Leu Ala Asp Pro Ile Tyr Ala 
        275                 280                 285             


Ser Trp Phe Gly Ser Arg Leu Tyr Asp His Phe Gly Ser Phe Lys Asn 
    290                 295                 300                 


Ser Leu Pro Leu Glu Leu Lys Asp Pro Phe Lys Glu Gln Ile Trp Ala 
305                 310                 315                 320 


Leu His Asn Ser Val Arg Gln Phe Tyr Gln Arg Met Ala Lys Ser Asp 
                325                 330                 335     


Arg Phe Arg Leu Ala Leu Gln Asn Ala Arg Ser Glu Val Pro Asp Arg 
            340                 345                 350         


Ser Glu Leu Leu Ala Leu Leu Pro Lys Asp His Asp His Leu Leu Leu 
        355                 360                 365             


Val Leu Gly Gly Lys Lys Lys Asn Ala Glu Met Ser Glu Leu Ile Arg 
    370                 375                 380                 


Leu Gly Lys Leu Phe Val His Ala Ser Asp Val Leu His Asp Phe Asp 
385                 390                 395                 400 


Ala Asn Asp Ala Ala Ala Leu Asp Ala Phe Lys Arg Arg Met Ser Phe 
                405                 410                 415     


Leu Ala Thr Ser Ile Gly Gln Ser Glu Ile Lys Gln Thr Glu Thr Phe 
            420                 425                 430         


Ala Arg Thr Trp Arg Gly Ala Val Gly Leu Thr Leu Arg Thr Val Lys 
        435                 440                 445             


Gly Leu Ala Asp Pro Arg Gly Ile Ile Gly Thr Pro Asp Asn Arg Asp 
    450                 455                 460                 


Leu Gly Thr Ala Gly Pro Met Lys Asp Ala Phe Asn Lys Phe Asp Gln 
465                 470                 475                 480 


Pro His Phe Gln Gln His Met Thr Ile Ile Phe Gly Asn Lys Glu Leu 
                485                 490                 495     


Gln Ala Glu Gly Asn Pro Thr Arg Ser Ser Val Phe Thr Ala Asn Gly 
            500                 505                 510         


Asp Lys Asp His Gln Ala Glu Leu Leu Trp Gly Phe Leu Cys Val Val 
        515                 520                 525             


Arg Ser Val Arg Asn Arg Thr Asn His Tyr Asn Val Arg Arg Ala Leu 
    530                 535                 540                 


Leu Arg Leu Leu Asp Glu Gly Ile Val Ser Pro Met Pro Ser Asp Pro 
545                 550                 555                 560 


Lys Lys Glu Arg Val Glu Asn Arg Asn Leu Cys Thr Val Ser Pro Thr 
                565                 570                 575     


Ala Leu Glu Ala Phe Arg Arg Leu Leu Asn Phe Asp Leu Ala Ile Gln 
            580                 585                 590         


Lys Glu Ala Val Arg Thr Ala Leu Glu Gln Ala Lys Ala Ser Glu Phe 
        595                 600                 605             


Val Glu Glu Gly Lys Leu Arg Gly Leu Val Ser Glu Leu Ala Gly Thr 
    610                 615                 620                 


Glu Asp Met Pro Ala Leu His Ile Pro Arg Phe Ser Ala Val Met Asp 
625                 630                 635                 640 


Lys Val Arg Arg Leu Ala Asp Asn Arg Asp Val Gly Leu Asp Pro Ile 
                645                 650                 655     


Leu Ser Thr Leu Gln Arg Ser Leu Pro Pro Thr Asp Lys Gln Ala Glu 
            660                 665                 670         


Ser Asp Ala Ala Arg Cys Arg Tyr Arg Leu Leu Leu Glu Leu Tyr Lys 
        675                 680                 685             


Ser Gly Phe Arg Ser Trp Phe Ser Gly Ile Gln Ser Asn Glu Glu Asn 
    690                 695                 700                 


Asn Arg Glu Ile Cys His Trp Ala Val Lys Gln Val Gly Arg Ala Lys 
705                 710                 715                 720 


Asp Ala Arg Lys Ser Glu Tyr Asp Lys Lys Thr Lys Arg His Tyr Arg 
                725                 730                 735     


Ser Pro Asn Ser Leu Ile Asp Asp Leu Gly Leu Asp Lys Phe Asp Asp 
            740                 745                 750         


Leu Thr Asp Leu Leu Glu Ala Leu Ala Ser Gln Ser Thr Arg Glu His 
        755                 760                 765             


Asp Gln Asn Leu Lys Tyr Val Pro Asp Ala Arg Val Gln Ser Gln Met 
    770                 775                 780                 


Ser Asn Arg Ile Glu Glu Phe Arg Gln Glu Leu Phe Ala His Ile Phe 
785                 790                 795                 800 


Thr Lys Tyr Leu Asp Thr His Asp Phe Gly Trp Ile Gly Ala Ile Glu 
                805                 810                 815     


Val Arg Arg Glu Ala Cys Asp Leu Ala Asp Val Val Ser Ala Phe Glu 
            820                 825                 830         


Val Arg Asp Gln Lys Phe Asp Ala Asp Trp His Ser Gln Phe Tyr Ala 
        835                 840                 845             


Trp Leu Tyr Met Val Pro Pro Ile Glu Ala Ser Arg Leu Arg His Gln 
    850                 855                 860                 


Met Arg Lys Ser Ala Val Met Asp Asp Lys Trp Ser Thr Thr Leu Glu 
865                 870                 875                 880 


Leu Thr Ser Gly Asp Arg Lys Thr Arg Asp Asp His Ala Gln Asp Val 
                885                 890                 895     


Leu Ala Asp Met Asp Arg Leu Phe Ser Leu Tyr Thr Lys Val Gln Ala 
            900                 905                 910         


Ala Gly Phe Asn Gly Gln Glu His Glu Ser Ala Leu Gly Ser Lys Ser 
        915                 920                 925             


Leu Phe Tyr Glu Asp Gly Asn Gln Phe Asp Glu Val Tyr Ser Pro Asp 
    930                 935                 940                 


Thr Glu Thr His Asn Lys Thr Phe Pro Gly Thr Arg Arg Gly Leu Arg 
945                 950                 955                 960 


Gln Leu Val Arg Tyr Ala His Leu Pro Ala Leu Glu Gly Val Phe Lys 
                965                 970                 975     


Lys His Arg Ile Thr Lys Ala Glu Val Glu Thr Phe Val Ala Leu Tyr 
            980                 985                 990         


Asp Glu Asn Arg Arg Asp Pro Gly  Ser Val Ala His Met  Leu Arg Arg 
        995                 1000                 1005             


Glu Lys  Leu Arg Thr Glu Ile  Leu Arg Ser Ile His  Asp Gly Pro 
    1010                 1015                 1020             


Lys Pro  Lys Asp Lys Asp Phe  Trp Pro Lys Leu Glu  Ala Lys Cys 
    1025                 1030                 1035             


Leu Glu  Tyr Arg Thr Val Ala  Thr Glu Thr Ala Ile  Tyr Asn Phe 
    1040                 1045                 1050             


Gln Ala  Asn Ala Ala Arg Leu  Asn Asp His Ala Arg  Leu His Gln 
    1055                 1060                 1065             


Ile Val  Met Arg Val Val Ala  Arg Leu Thr Asp Tyr  Ala Leu Ile 
    1070                 1075                 1080             


Trp Glu  Arg Asp Arg Leu Phe  Ala Phe Val Gly Met  Leu Tyr Arg 
    1085                 1090                 1095             


Gln Thr  Gly Gly Thr Gly Ile  Asn Pro Ala Met Arg  His Ala Glu 
    1100                 1105                 1110             


Lys Thr  Asn Ala Pro Pro Arg  Ile Gly Ile Leu Val  Ser Asp Ser 
    1115                 1120                 1125             


Ala Leu  Ala Lys Lys Leu Asn  Ser Asn Ser Ala Glu  Val Phe Ile 
    1130                 1135                 1140             


Pro Tyr  Leu Asp Thr Glu Thr  Gly Phe Asp Ala Pro  Arg Phe Asp 
    1145                 1150                 1155             


Asp Leu  Cys Thr Leu Leu Ser  His Glu His Ala Lys  Glu Phe Arg 
    1160                 1165                 1170             


Phe His  Phe Leu Glu Val Gly  Glu Glu Asn Ser Lys  Asp Glu Ala 
    1175                 1180                 1185             


Arg Arg  Leu Asn Glu Glu Thr  Met Gly His Arg Lys  Arg Pro Ala 
    1190                 1195                 1200             


Phe Lys  Arg Gly Thr Arg Arg  Gln Gly Ile Arg Asn  Asp Leu Ala 
    1205                 1210                 1215             


His His  Asn Val Leu Asp Leu  Ala Gly Gly Ala Gly  Pro Asn Leu 
    1220                 1225                 1230             


Thr Tyr  Val Val Asn Ala Val  Arg Ser Leu Leu Ser  Tyr Asp Arg 
    1235                 1240                 1245             


Lys Leu  Lys Asn Ala Val Pro  Lys Ser Ile Lys Arg  Ile Leu Gly 
    1250                 1255                 1260             


Glu Glu  Gly Leu Ile Ile Glu  Trp Gln Met Asn Tyr  Asp Arg Leu 
    1265                 1270                 1275             


Lys Lys  Pro Thr Val Tyr Pro  Asn Val Glu Thr His  Leu Thr Met 
    1280                 1285                 1290             


Val Pro  Pro Arg His Met Thr  Ala Pro Val Ser Phe  Thr Leu Pro 
    1295                 1300                 1305             


Arg Ala  Ser Val Arg Leu Ala  Ser Met Val Lys Ala  Val Phe Asp 
    1310                 1315                 1320             


Phe Gly  Ser Ser Gly Tyr Gly  Glu Glu Arg Met Ile  Gly Gly Arg 
    1325                 1330                 1335             


Thr Ala  Lys Gln Ala Val Tyr  Pro Asp Asp Phe Thr  Arg Arg Phe 
    1340                 1345                 1350             


Pro Gln  Thr Pro Met Gly Leu  Lys Gln Ala Thr Arg  Leu Val Phe 
    1355                 1360                 1365             


Ala Ser  Glu Asn Ser 
    1370             


<210>  815
<211>  1330
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  815

Met Lys Arg Glu Lys Asn Ile Thr Ile Met Lys Ile Ser Lys Val Asn 
1               5                   10                  15      


His Arg Arg Met Ala Val Ala Leu Asn Gly Asp Lys Ser Glu Leu Gly 
            20                  25                  30          


Gly Ile Leu Tyr Glu Ala Pro Val Gln Lys Asp Lys Asn Gly Asn Tyr 
        35                  40                  45              


Asn Asp Val Ile Ala Glu Thr Gly Lys Val Val Asn Glu Ala Leu Asp 
    50                  55                  60                  


Lys Lys Ser Arg Leu Tyr Thr Pro Phe Asn Asn Gln Lys Val Ile Ile 
65                  70                  75                  80  


Asp Lys Asn Leu Gln Arg Tyr Ala Asn Asn Leu Lys Arg Cys Tyr Ile 
                85                  90                  95      


Asn Phe Val Lys Gln Tyr Val Asn Asn Lys Ser Phe Asn Tyr Lys Ala 
            100                 105                 110         


Met Gln Phe Ile Pro Asp Ile Gln Asn Pro Lys Thr Asn Asp Ala Val 
        115                 120                 125             


Asn Tyr Arg Thr Asp Arg Asp Asn Val Tyr Asn Lys Asn Lys Tyr Tyr 
    130                 135                 140                 


Asp Lys Gln Thr Lys Ser Lys Ser Lys Lys Phe Ile Tyr Glu Lys Ile 
145                 150                 155                 160 


Val Ile Pro Gln Asn Glu Gln Asn Ile Val Ile Ser Ala Leu Val Asn 
                165                 170                 175     


Cys Ser Leu Arg Lys Ser Leu Arg Lys Asp Val Ser Tyr Lys Thr Lys 
            180                 185                 190         


Ser Gly Glu Ile Lys Thr Tyr Asn Leu Pro Glu Leu Val Lys Lys Ser 
        195                 200                 205             


Met Arg Phe Tyr Cys Leu Glu Gly Gln Arg Glu Pro Asp Glu Lys Glu 
    210                 215                 220                 


Lys Tyr Glu Met Tyr Ile Leu Phe Ser Tyr Met Lys Glu Asp Lys Arg 
225                 230                 235                 240 


Thr Lys Asn Thr Asp Leu Leu Val Lys Ser Ile Ser Asn Gln Asn Thr 
                245                 250                 255     


Lys Val Lys Val Glu Asp Ile Asp Gly Asn Lys Leu Leu Lys Leu Ser 
            260                 265                 270         


Ile Ala Asp Thr Lys Lys Lys Pro Leu Trp Glu Tyr Leu Ile Lys Tyr 
        275                 280                 285             


Ala Asp Ser Ser Arg Gln Arg Glu Leu Met Tyr Asp Ile Arg Lys Lys 
    290                 295                 300                 


Ile Val Leu Tyr Val Val Gly Ile Glu Glu Tyr Glu Asn Ile Lys Glu 
305                 310                 315                 320 


Asp Ser Gly Leu Ser Lys Val Ser Trp Ser Lys Tyr Asn Ile Ser Asp 
                325                 330                 335     


Asn Lys Met Phe Val Asp Ile Asn Ser Cys Thr Asp Lys Arg Lys Gln 
            340                 345                 350         


Asn Leu Glu Leu Lys Ile Arg Glu Ala Asn Ile Glu His Tyr Arg Asn 
        355                 360                 365             


Ala Ser Ser Lys Leu Cys Asp Asp Glu Ser Ile Phe Trp Phe Gln His 
    370                 375                 380                 


Phe Glu Gly Val Ile Glu Thr Leu Phe Ser Lys Lys Ser Lys Ile Ser 
385                 390                 395                 400 


Glu Glu Arg Leu Gly Cys Ala Tyr Ile Cys Asp Tyr Leu Trp Lys Asp 
                405                 410                 415     


Phe Leu Ser Tyr Leu Ala Ala Lys Tyr Ile Asp Leu Gly Lys Gly Val 
            420                 425                 430         


Tyr His Phe Thr Met Lys Asp Lys Leu Asp Met Leu Asn Lys Asn Glu 
        435                 440                 445             


Ala Val Thr Asp Leu Arg Phe Gly Ile Val Ser Glu Lys Tyr Glu Lys 
    450                 455                 460                 


Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Glu Leu 
465                 470                 475                 480 


Asp Arg Asn Ile Ala Ala Tyr Val Thr Phe Ala Ala Asp Ile Phe Ala 
                485                 490                 495     


Lys Ser Val Ile Lys Ser Asp Tyr Arg Thr Lys Lys Asp Asn Asn Ser 
            500                 505                 510         


Asp Val Leu Gln Tyr Ser Asp Lys Glu Phe Arg Asn Ser Glu Val Ile 
        515                 520                 525             


Arg Asp Asn Ala Glu Lys Asn Ile Leu Gln Tyr Trp Gly Gly Tyr Ser 
    530                 535                 540                 


Arg Trp Gly Thr Glu Asn Ser Lys Leu Pro Glu Asn Asn Lys Val Ser 
545                 550                 555                 560 


Asp Phe Gly Lys Leu Asp Val Ser Asp Leu Cys Ile Asp Ile Lys Lys 
                565                 570                 575     


His Leu Ala Gly Ile Arg Asn Ser Ser Val His Tyr Thr Thr Lys Ile 
            580                 585                 590         


Lys Asn Glu Ser Ala Ala Asp Gly Ser Asn Val Lys Ile Leu Phe Glu 
        595                 600                 605             


Lys Asp Leu Ala Asp Ile Asn Ile Ile Tyr Ala Asp Lys Tyr Tyr Ser 
    610                 615                 620                 


Asn Asn Val Trp Met Phe Tyr Ser Leu Glu Asp Ile Asn Lys Leu Ile 
625                 630                 635                 640 


Ala Phe Leu Tyr Lys Glu Lys Arg Val Ile Arg Gln Val Gln Ile Pro 
                645                 650                 655     


Ser Phe Ser Arg Ile Leu Lys Arg Lys Ala Met Gln Asp Val Ile Asn 
            660                 665                 670         


Glu Ile Phe Lys Asp Asp Phe Asp Glu Asn Ile Val Asn Pro Glu Leu 
        675                 680                 685             


Lys Glu Lys Tyr Arg Asn Ser Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
    690                 695                 700                 


Tyr Asn Ala Phe Ile Ile Gln Pro Glu Leu Lys Glu Lys Phe Lys Asp 
705                 710                 715                 720 


Lys Ile Lys Thr Met Lys Ser Glu Leu Tyr Asn Lys Leu Lys Thr Ile 
                725                 730                 735     


Asp Lys Lys Glu Tyr Lys Ala Leu Tyr Cys Met Leu Ser Asn Glu Glu 
            740                 745                 750         


Ser Ala Leu Lys Asn Phe Ala Asp Arg Ile Tyr Ser Val Asp Gly Asp 
        755                 760                 765             


Asn Val Ser Phe Ala Asp Ile Cys Lys Ile Leu Met Thr Asp Tyr Asn 
    770                 775                 780                 


Met Gln Asn Gln Glu Lys Lys Asn Ile Glu Ser Met Glu Gln Lys Lys 
785                 790                 795                 800 


Lys Asn Lys Gly Lys Asp Glu Asn Tyr Lys His Phe Pro Leu Leu Leu 
                805                 810                 815     


His Lys Val Leu Lys Lys Leu Phe Ile Glu Tyr Leu Lys Gln Thr His 
            820                 825                 830         


Glu Leu Glu Phe Leu Arg Asn Asn Ile Cys Ile Lys Ser Asp Val Thr 
        835                 840                 845             


Met Glu Ser Phe Glu Ser Gln Ile Lys Gly Val Glu Ile Tyr Lys Asp 
    850                 855                 860                 


Leu Lys Glu Lys Ile Asp Lys Asn Asn Ser Leu Leu Asp Trp Tyr Val 
865                 870                 875                 880 


Ile Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asn 
                885                 890                 895     


Ile Lys Asn Tyr Ile Gln Phe Ala Thr Asn Ile Asp Lys Arg Ala Glu 
            900                 905                 910         


Ser Val Lys Asn Leu Thr Glu Ser Gly Met Val Lys Arg Ile Gln Tyr 
        915                 920                 925             


Tyr Asp Asp Ile Val Arg Thr Leu Glu Phe Ser Ala Gln Tyr Ile Gly 
    930                 935                 940                 


Lys Ile Ser Asn Asn Ile Asn Asp Tyr Phe Asn Ser Glu Asp Glu Tyr 
945                 950                 955                 960 


Val Ser Phe Leu Ser Lys Tyr Val Gly Phe Ile Asn Asp Lys Ser Glu 
                965                 970                 975     


Asp Val Leu Thr Glu Leu Lys Asp Phe Cys Arg Glu Lys Ile Asn Asn 
            980                 985                 990         


Gly Ser Gln Ile Ile Gly Ile Tyr  Tyr Gly Gly Asp Asn  Val Ile Ile 
        995                 1000                 1005             


Asn Arg  Asn Val Ile Tyr Ala  Gln Met Tyr Ser Asn  Ala Glu Val 
    1010                 1015                 1020             


Phe Ser  Asn Ile Tyr Lys Lys  Val Thr Lys Asn Asp  Ile Ile Asn 
    1025                 1030                 1035             


Tyr Tyr  Glu Lys Gln Asn Asp  Leu Lys Asp Val Phe  Lys Ser Gly 
    1040                 1045                 1050             


Val Cys  Gln Asn Glu Gly Glu  Gln Arg Ser Leu Cys  Glu Phe Gln 
    1055                 1060                 1065             


Gln Leu  Lys Asn Arg Ile Glu  Leu Thr Glu Leu Ser  Thr Tyr Ala 
    1070                 1075                 1080             


Asp Met  Val Asn Asp Phe Met  Ala Gln Phe Val Glu  Trp Ala Tyr 
    1085                 1090                 1095             


Leu Arg  Glu Arg Asp Leu Met  Tyr Phe Gln Leu Gly  Ile His Tyr 
    1100                 1105                 1110             


Ile Arg  Leu Phe Tyr Ser Asp  Asn Val Leu Asp Lys  Lys Tyr His 
    1115                 1120                 1125             


Lys Leu  Ser Asp Asn Val Ile  Asp Ile Glu Glu Gly  Ala Leu Leu 
    1130                 1135                 1140             


Tyr Gln  Ile Val Ala Met Tyr  Asp Tyr Glu Leu Arg  Ile Phe Glu 
    1145                 1150                 1155             


Thr Asp  Asn Ser Gly Asn Ala  Lys Arg Ile Gly Gln  Gly Gly Pro 
    1160                 1165                 1170             


Gly Lys  Ser Ile Pro Val Phe  Leu Lys Lys Tyr Cys  Asn Gly Thr 
    1175                 1180                 1185             


Asp Val  Tyr Glu Cys Gly Leu  Glu Leu Phe Glu Asp  Ile Asn Gln 
    1190                 1195                 1200             


His Glu  His Ile Ile Arg Phe  Arg Asn Asp Ile Ala  His Met Arg 
    1205                 1210                 1215             


Tyr Met  Ser Asn Gln Ala Met  Asn Ile Met Ser Ile  Val Ser Asn 
    1220                 1225                 1230             


Ile Tyr  Lys Ser Phe Phe Val  Tyr Asp Thr Lys Leu  Lys Lys Ser 
    1235                 1240                 1245             


Ile Ser  Leu Val Phe Lys Asn  Ile Leu Met Arg Tyr  Gly Val Ile 
    1250                 1255                 1260             


Ala Asp  Leu Val Phe Ser Tyr  Asn Asn Lys Asn Gln  Ser Ile Lys 
    1265                 1270                 1275             


Asp Asp  Met Asp Ile Asn Ile  Ile Asn Ile Lys Asn  Leu Lys Ser 
    1280                 1285                 1290             


Asp Lys  Tyr Val Tyr Lys Ile  Val Asn Glu Asp Ile  Val Lys Gln 
    1295                 1300                 1305             


Val Glu  Ile Glu Ile Arg Asn  Gln Val Phe Leu Glu  Gln Leu His 
    1310                 1315                 1320             


Asn Leu  Leu Tyr Phe Ser Arg  
    1325                 1330 


<210>  816
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  816

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Thr Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Gly Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Asp Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val His Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1400                 1405                 1410         


<210>  817
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  817

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Gly Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Tyr Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Val 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Lys Ile Leu Lys Tyr Thr Glu Ser Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Lys 
        915                 920                 925             


Lys Tyr Glu Lys Ala Ile Arg Asn Ile Gln Gln Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Ser Leu Leu Leu 
945                 950                 955                 960 


Arg Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile His 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Asn Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Ser Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asp  Thr Glu Lys Ile Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Glu Leu  Lys Lys Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Thr Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Glu Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Lys  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  818
<211>  1261
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  818

Met Tyr Met Lys Ile Thr Lys Ile Asp Gly Val Ser His Tyr Lys Glu 
1               5                   10                  15      


Lys Glu Lys Gly Val Leu Lys Gly Lys Asp Ile Leu Asn Gly Lys Ile 
            20                  25                  30          


Glu Lys Ile Val Lys Lys Arg Tyr Asp Ala Thr Ile Glu Ser Lys Ile 
        35                  40                  45              


Tyr Lys Glu Phe Ile Lys Leu Arg Lys Asn Arg Ile Glu Gln Asn Asn 
    50                  55                  60                  


Glu Lys Ser Ile Leu Lys Leu Ile Lys Leu Asn Ile Asp Lys Asn Glu 
65                  70                  75                  80  


Lys Glu Ile Lys Thr Leu Leu Leu Asn Lys Phe Lys Ile Lys Glu Lys 
                85                  90                  95      


Asn Lys Lys Tyr Asp Lys Tyr Met Leu Asp Glu Asn Lys Leu Asp Asn 
            100                 105                 110         


Asp Ile Lys Ile Tyr Glu Ser Val Glu Ser Leu Tyr Phe Leu Ile Lys 
        115                 120                 125             


Glu Ile Tyr Leu Gly Gln Asn Asn Lys Lys Trp Asn Ile Ser Lys Ile 
    130                 135                 140                 


Asp Leu Glu Lys Ile Met Glu Glu Asp Asn Asn Leu Ile Met Leu Gly 
145                 150                 155                 160 


Tyr Lys Leu Lys Lys Asn Ile Thr Glu Asn Asp Tyr Pro Tyr Leu Tyr 
                165                 170                 175     


Ser Asp Lys Asn Gly Gln Glu Ser Thr Ser Val Tyr Lys Leu Leu Lys 
            180                 185                 190         


Lys Leu Ile Glu Glu Asn Lys Asp Arg Asn Gln Asp Ile Arg Lys Ser 
        195                 200                 205             


Gln Glu Tyr Glu Lys Ile Arg Lys Asn Phe Glu Glu Tyr Lys Asn Arg 
    210                 215                 220                 


Lys Ile Asn Leu Leu Val Lys Ser Ile Lys Asn Asn Lys Ile Asn Ile 
225                 230                 235                 240 


Gln Tyr Ile Asn Asn Glu Ile Lys Ser His Asn Asn Ser Arg Glu Glu 
                245                 250                 255     


Asn Ile Ile Lys Phe Phe Lys Lys Met Ile Glu Glu Lys Asn Lys Ser 
            260                 265                 270         


Ile Leu Lys Asp Lys Leu Lys Leu Phe Lys Leu Glu Val Phe Phe Asp 
        275                 280                 285             


Glu Glu Phe Leu Glu Glu Ile Lys Lys Leu Leu Asp Ser Asp Asp Phe 
    290                 295                 300                 


Asp Lys Ser Tyr Asn Lys Lys Ile Ser Glu Leu Arg Gly Lys Ile Phe 
305                 310                 315                 320 


Asn Arg Ile Arg Glu Glu Ile Lys Asn Asn Lys Asn Arg Asp Glu Leu 
                325                 330                 335     


Glu Asn Ile Tyr Phe Leu Glu Leu Lys Lys Tyr Ile Glu Asn Asn Leu 
            340                 345                 350         


Ser His Lys Lys Glu Lys Asn Lys Asn Asn Asn Asn Thr Gly Glu Glu 
        355                 360                 365             


Lys Ser Lys Glu Leu Tyr Leu Lys Phe Leu Lys Lys Val Leu Phe Ile 
    370                 375                 380                 


Asp Asp Asn Asn Arg Ile Ser Ile Glu Lys Leu Lys Ser Arg Ile Asp 
385                 390                 395                 400 


Asp Asn Phe Lys Asn Leu Leu Ile Gln His Val Ile Glu Tyr Gly Lys 
                405                 410                 415     


Ile Lys Tyr Tyr Val Glu Asn Asp Asp Tyr Ile Arg Asn Ile Val Lys 
            420                 425                 430         


Asn Gly Glu Leu Lys Leu Glu Thr Lys Asp Leu Glu Tyr Ile Lys Thr 
        435                 440                 445             


Lys Glu Thr Leu Ile Arg Lys Met Ala Val Leu Val Ser Phe Ala Ala 
    450                 455                 460                 


Asn Ser Tyr Tyr Asn Leu Phe Gly Arg Thr Glu Asn Asn Ile Leu Thr 
465                 470                 475                 480 


Gln Glu Ile Ser Asp Asp Leu Leu Leu Gly Lys Ile Glu Asn Glu Ile 
                485                 490                 495     


Tyr Ile Lys Gly Glu Lys Asn Arg Arg Tyr Val Phe Lys Glu Lys Met 
            500                 505                 510         


Leu Asn Tyr Phe Phe Asn Pro Glu Ile Phe Gly Asp Asn Lys Ile Val 
        515                 520                 525             


Glu Val Leu Ser Ala Ile Ser Ser Ser Ile Tyr Asn Ile Arg Asn Gly 
    530                 535                 540                 


Val Asn His Phe Asp Lys Met Val Leu Gly Lys Asp Asn Asn Gly Leu 
545                 550                 555                 560 


Asp Leu Lys Asp Ser Asp Thr Ile Lys Asp Tyr Phe His Phe Lys Lys 
                565                 570                 575     


Lys Glu Ile Gln Gln Asp Leu Lys Asp Arg Phe Ile Tyr Asn Asn Leu 
            580                 585                 590         


Gln Tyr Tyr Tyr Thr Glu Asn Glu Ile Lys Lys Tyr Phe Glu Lys Tyr 
        595                 600                 605             


Lys Phe Glu Ile Leu Lys Thr Lys Ala Ser Phe Ala Pro Asn Phe Lys 
    610                 615                 620                 


Arg Ile Leu Ile Lys Gly Glu Asn Leu Ser Ile Ser Glu Ser Asn Asn 
625                 630                 635                 640 


Ser Tyr Glu Phe Phe Lys Ala Tyr Ser Glu Ser Ser Asp Lys Asn Thr 
                645                 650                 655     


Glu Tyr Asn Glu Phe Met Lys Thr Arg Asn Phe Leu Leu Lys Glu Leu 
            660                 665                 670         


Tyr Tyr Asn Asn Phe Tyr Thr Glu Phe Leu Asn Asn Lys Ala Lys Phe 
        675                 680                 685             


Lys Glu Ala Val Glu Lys Val Lys Glu Asn Lys Lys Arg Arg Gly Gly 
    690                 695                 700                 


Lys Ser Tyr Asp Val Ile Gly Asn Tyr Asn Phe Ser Asp Asn Ile Pro 
705                 710                 715                 720 


Glu Tyr Ile Ser Tyr Ile His Lys Ser Glu Met Glu Arg Ile Glu Ile 
                725                 730                 735     


Asn Thr Glu Lys Asn Arg Lys Asp Thr Ser Lys His Ile Arg Asp Phe 
            740                 745                 750         


Ile Glu Glu Val Phe Leu Glu Gly Phe Ile Lys Tyr Leu Asp Asn Asn 
        755                 760                 765             


Asn Leu Asn Phe Leu Lys Asn Arg Asn Lys Val Asp Lys Glu Arg Glu 
    770                 775                 780                 


Glu Ile Val Arg Asn Leu Asn Ile Arg Ile Glu Gly Leu Asp Ile Leu 
785                 790                 795                 800 


Asn Glu Asp Asp Ser Glu Ile Leu Asn Leu Tyr Leu Phe Phe Asn Met 
                805                 810                 815     


Ile Asp Asn Lys Arg Ile Ser Glu Phe Arg Asn Asp Met Ile Lys Tyr 
            820                 825                 830         


Lys Gln Phe Leu Ala Lys Arg Gln Asn Ile Asp Ser Lys Phe Leu Lys 
        835                 840                 845             


Ile Asp Ile Glu Lys Ile Glu Ala Ile Ile Glu Phe Val Ile Ile Thr 
    850                 855                 860                 


Lys Glu Lys Leu Glu Ile Leu Glu Gly Glu Thr Lys Glu Gln Lys Lys 
865                 870                 875                 880 


Asp Asn Met Asn Ala Leu Phe Asn Lys Phe Tyr Ser Ser Glu Ser Glu 
                885                 890                 895     


Tyr Asp Glu Lys Leu Lys Lys Phe Ile Glu Glu Ala Ile Leu Gly Asp 
            900                 905                 910         


Lys Lys Asn Thr Pro Phe Tyr Ser Thr Asp Gly Lys Thr Pro Ile Val 
        915                 920                 925             


His Ser Asn Leu Glu Lys Met Lys Lys Tyr Gly Thr Glu Asn Phe Leu 
    930                 935                 940                 


Ser Lys Val Leu Lys Asp Ser Asn Tyr Thr Leu Asn Asn Met Thr Ala 
945                 950                 955                 960 


Lys Glu Lys Phe Glu Ala Lys Val Ser Asp Glu Leu Lys Glu Tyr Lys 
                965                 970                 975     


Ile Leu Glu Lys Val Asn Arg Phe Lys Glu Lys Gly Lys Pro Lys Lys 
            980                 985                 990         


Val Ile Glu Tyr Tyr Asn Asp Cys  Lys Cys Tyr Leu His  Lys Glu Trp 
        995                 1000                 1005             


Ile Glu  Lys Lys Lys Ser Glu  Glu Glu Phe Glu Cys  Lys Glu Ile 
    1010                 1015                 1020             


Tyr Lys  Lys Ile Ile Glu Glu  Ile Arg Lys Tyr Asn  Tyr Leu Glu 
    1025                 1030                 1035             


Asn Lys  Glu Lys Leu Gln Asn  Val Tyr Leu Leu His  Glu Ile Leu 
    1040                 1045                 1050             


Ser Asp  Leu Leu Ala Arg Asn  Val Ala Phe Phe Asn  Lys Trp Glu 
    1055                 1060                 1065             


Arg Asp  Phe Lys Phe Ile Val  Ile Ala Ile Lys Gln  Phe Leu Arg 
    1070                 1075                 1080             


Glu Asn  Asp Lys Glu Lys Val  Asn Glu Phe Leu Asn  Pro His Lys 
    1085                 1090                 1095             


Ser Asp  Gly Ser Arg Asp Asn  Phe Ser Val Thr Asn  Tyr Arg Ser 
    1100                 1105                 1110             


Lys Met  Lys Ser Ile Ile Asn  Asn Ile His Glu Asn  Phe Met Ser 
    1115                 1120                 1125             


Leu Leu  Phe Leu Asn Asn Asn  Leu Ala Thr Gly Gly  Ile Gln Met 
    1130                 1135                 1140             


Gly Arg  Asn Asn Asn Phe Thr  Trp Gly Asn Leu Arg  Asn Tyr Ile 
    1145                 1150                 1155             


Ala His  Phe Glu Tyr Leu His  Lys Glu Lys Asp Thr  Ile Ser Phe 
    1160                 1165                 1170             


Ile Gly  Gln Ala Asn Leu Leu  Ile Lys Leu Phe Ser  Tyr Asp Lys 
    1175                 1180                 1185             


Lys Val  Gln Asn His Ile Ile  Lys Ser Met Lys Thr  Leu Leu Glu 
    1190                 1195                 1200             


Lys Tyr  Asn Ile Glu Ile Arg  Phe Glu Ile Ser Asn  Asp Ser Glu 
    1205                 1210                 1215             


Glu Ile  Phe Glu Tyr Lys Ile  Lys Tyr Ile Asn Ser  Lys Lys Gly 
    1220                 1225                 1230             


Lys Met  Leu Gly Lys Asn Asn  Glu Phe Glu Ile Leu  Glu Asn Glu 
    1235                 1240                 1245             


Phe Val  Arg Asn Val Lys Ala  Leu Leu Glu Tyr Ser  Glu 
    1250                 1255                 1260     


<210>  819
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  819

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Val 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Lys Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Met 
    690                 695                 700                 


Tyr Ile Gly Asn Asp Glu Gln Ile Asn Thr Ser Leu Ala Gly Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Lys Ile Leu Lys Tyr Thr Glu Ser Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Thr Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Glu Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Lys  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  820
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  820

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Gly Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Glu 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Val Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Thr Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Lys Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Glu  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  821
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  821

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Leu Tyr Gln Ile Val  Ser Ala Phe Asn Phe  Gly Ser Lys 
    1205                 1210                 1215             


Leu Leu  Tyr Ile Ser Glu Asp  Gly Arg Trp Lys Met  Ala Gly Gly 
    1220                 1225                 1230             


Ala Phe  Pro Gly Lys Tyr Gly  Arg Phe Glu Asn Asp  Tyr Asn His 
    1235                 1240                 1245             


Arg Thr  Ser Leu Ser Lys Val  Ile Arg Leu Phe Glu  Asn Glu Ser 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ile Ile Tyr  Trp Arg Asp Tyr Val  Asp His Met 
    1265                 1270                 1275             


Lys Tyr  Tyr Val Asn Gln Asn  Gln Ser Ile Met Glu  Ile Tyr Ser 
    1280                 1285                 1290             


Ala Phe  Tyr Ser Lys Val Leu  Gly Tyr Ser Ala Lys  Leu Arg Lys 
    1295                 1300                 1305             


Ser Val  Val Phe Asn Leu Gln  Ala Ala Leu Glu Lys  His His Ile 
    1310                 1315                 1320             


Asn Pro  Glu Cys Ile Trp Met  Thr Ser Asp Gly Lys  Cys Ala Asp 
    1325                 1330                 1335             


Ile Lys  Leu Met Lys Asn Leu  Glu Ser Gln Lys Phe  Thr Tyr Lys 
    1340                 1345                 1350             


Leu Ala  Lys Arg Glu Gly Glu  Lys Thr Glu Arg Lys  Ile Cys Met 
    1355                 1360                 1365             


Asn Ala  Leu Asn Glu Asn Phe  Leu Lys Thr Ile Arg  Thr Ser Leu 
    1370                 1375                 1380             


Glu Tyr  Lys Lys 
    1385         


<210>  822
<211>  1330
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  822

Met Lys Arg Glu Lys Asn Ile Thr Ile Met Lys Ile Ser Lys Val Asn 
1               5                   10                  15      


His Arg Arg Thr Ala Val Ala Leu Asn Gly Asp Lys Ser Glu Leu Gly 
            20                  25                  30          


Gly Ile Leu Tyr Glu Ala Pro Val Gln Lys Asp Lys Asn Gly Asn Tyr 
        35                  40                  45              


Asn Asp Val Ile Ala Glu Thr Gly Lys Val Val Asn Glu Ala Leu Asp 
    50                  55                  60                  


Lys Lys Ser Arg Leu Tyr Thr Pro Phe Asn Asn Gln Lys Val Ile Ile 
65                  70                  75                  80  


Asp Lys Asn Leu Gln Arg Tyr Ala Asn Asn Leu Lys Arg Cys Tyr Ile 
                85                  90                  95      


Asn Phe Val Lys Gln Tyr Val Asn Asn Lys Ser Phe Asn Tyr Lys Ala 
            100                 105                 110         


Met Gln Phe Ile Pro Asp Ile Gln Asn Pro Lys Thr Asn Asp Ala Val 
        115                 120                 125             


Asn Tyr Arg Thr Asp Arg Asp Asn Val Tyr Asn Lys Asn Lys Tyr Tyr 
    130                 135                 140                 


Asp Lys Gln Thr Lys Ser Lys Ser Lys Lys Phe Ile Tyr Glu Lys Ile 
145                 150                 155                 160 


Val Ile Pro Gln Asn Glu Gln Asn Ile Val Ile Ser Ala Leu Val Asn 
                165                 170                 175     


Cys Ser Leu Arg Lys Ser Leu Arg Lys Asp Val Ser Tyr Lys Thr Lys 
            180                 185                 190         


Ser Gly Glu Ile Lys Thr Tyr Asn Leu Pro Glu Leu Val Lys Lys Ser 
        195                 200                 205             


Met Arg Phe Tyr Cys Leu Glu Gly Gln Arg Glu Pro Asp Glu Lys Glu 
    210                 215                 220                 


Lys Tyr Glu Met Tyr Ile Leu Phe Ser Tyr Met Lys Glu Asp Lys Arg 
225                 230                 235                 240 


Thr Lys Asn Thr Asp Leu Leu Val Lys Ser Ile Ser Asn Gln Asn Thr 
                245                 250                 255     


Lys Val Lys Val Glu Asp Ile Asp Gly Asn Lys Leu Leu Lys Leu Ser 
            260                 265                 270         


Ile Ala Asp Thr Lys Lys Lys Pro Leu Trp Glu Tyr Leu Ile Lys Tyr 
        275                 280                 285             


Ala Asp Ser Ser Arg Gln Arg Glu Leu Met Tyr Asp Ile Arg Lys Lys 
    290                 295                 300                 


Ile Ile Leu Tyr Val Ala Gly Ile Glu Glu Tyr Glu Asn Ile Lys Glu 
305                 310                 315                 320 


Asp Ser Gly Leu Ser Lys Val Ser Trp Ser Lys Tyr Asn Ile Ser Asp 
                325                 330                 335     


Asn Lys Met Phe Phe Asp Ile Asn Ser Cys Thr Asp Lys Arg Lys Gln 
            340                 345                 350         


Asn Leu Glu Leu Lys Ile Arg Glu Ala Asn Ile Glu His Tyr Arg Asn 
        355                 360                 365             


Ala Ser Ser Lys Leu Cys Asp Asp Glu Ser Ile Phe Trp Phe Gln His 
    370                 375                 380                 


Phe Glu Gly Val Ile Glu Thr Leu Phe Ser Lys Lys Ser Lys Ile Ser 
385                 390                 395                 400 


Glu Glu Arg Leu Gly Cys Ala Tyr Ile Cys Asp Tyr Leu Trp Lys Asp 
                405                 410                 415     


Phe Leu Ser Tyr Leu Ala Ala Lys Tyr Ile Asp Leu Gly Lys Gly Val 
            420                 425                 430         


Tyr His Phe Thr Val Lys Asp Lys Leu Asp Met Leu Asn Lys Asn Glu 
        435                 440                 445             


Ala Val Thr Asp Leu Arg Phe Gly Ile Val Ser Glu Lys Tyr Glu Lys 
    450                 455                 460                 


Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Glu Leu 
465                 470                 475                 480 


Asp Arg Asn Ile Ala Ala Tyr Val Thr Phe Ala Ala Asp Ile Phe Ala 
                485                 490                 495     


Lys Ser Val Ile Lys Ser Asp Tyr Arg Thr Lys Lys Asp Asn Asn Ser 
            500                 505                 510         


Asp Val Leu Gln Tyr Ser Asp Lys Glu Phe Arg Asn Ser Glu Val Ile 
        515                 520                 525             


Arg Asp Asn Ala Glu Lys Asn Ile Leu Gln Tyr Trp Gly Gly Tyr Ser 
    530                 535                 540                 


Arg Trp Gly Thr Glu Asn Ser Lys Leu Pro Glu Asn Asn Lys Val Ser 
545                 550                 555                 560 


Asp Phe Gly Lys Leu Asp Val Ser Asp Leu Cys Ile Asp Ile Lys Lys 
                565                 570                 575     


His Leu Ala Gly Ile Arg Asn Ser Ser Val His Tyr Thr Thr Lys Ile 
            580                 585                 590         


Lys Asn Glu Ser Ala Ala Asp Gly Ser Asn Val Lys Ile Leu Phe Glu 
        595                 600                 605             


Lys Asp Leu Ala Asp Ile Asn Ile Ile Tyr Ala Asp Lys Tyr Tyr Ser 
    610                 615                 620                 


Asn Asn Val Trp Met Phe Tyr Ser Leu Glu Asp Ile Asn Lys Leu Ile 
625                 630                 635                 640 


Ala Phe Leu Tyr Lys Glu Lys Arg Val Ile Arg Gln Val Gln Ile Pro 
                645                 650                 655     


Ser Phe Ser Arg Ile Leu Lys Arg Lys Ala Met Gln Asp Val Ile Asn 
            660                 665                 670         


Glu Ile Phe Lys Asp Asp Phe Asp Glu Asn Ile Val Asn Pro Glu Leu 
        675                 680                 685             


Lys Glu Lys Tyr Arg Asn Ser Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
    690                 695                 700                 


Tyr Asn Ala Phe Ile Ile Gln Pro Glu Leu Lys Glu Lys Phe Lys Asp 
705                 710                 715                 720 


Lys Ile Lys Thr Met Lys Ser Glu Leu Tyr Asn Lys Leu Lys Thr Ile 
                725                 730                 735     


Asp Lys Lys Glu Tyr Lys Ala Leu Tyr Cys Met Leu Ser Asn Glu Glu 
            740                 745                 750         


Ser Ala Leu Lys Asn Phe Ala Asp Arg Ile Tyr Ser Val Asp Gly Asp 
        755                 760                 765             


Asn Val Ser Phe Ala Asp Ile Cys Lys Ile Leu Met Thr Asp Tyr Asn 
    770                 775                 780                 


Met Gln Asn Gln Glu Lys Lys Asn Ile Glu Ser Met Glu Gln Lys Lys 
785                 790                 795                 800 


Lys Asn Lys Gly Lys Asp Glu Asn Tyr Lys His Phe Pro Leu Leu Leu 
                805                 810                 815     


His Lys Val Leu Lys Lys Leu Phe Ile Glu Tyr Leu Lys Gln Thr His 
            820                 825                 830         


Glu Leu Glu Phe Leu Arg Asn Asn Ile Cys Ile Lys Ser Asp Val Thr 
        835                 840                 845             


Met Glu Ser Phe Glu Ser Gln Ile Lys Gly Val Glu Ile Tyr Lys Asp 
    850                 855                 860                 


Leu Lys Glu Lys Ile Asp Lys Asn Asn Ser Leu Leu Asp Trp Tyr Val 
865                 870                 875                 880 


Ile Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asn 
                885                 890                 895     


Ile Lys Asn Tyr Ile Gln Phe Ala Thr Asn Ile Asp Lys Arg Ala Glu 
            900                 905                 910         


Ser Val Lys Asn Leu Thr Glu Ser Gly Met Val Lys Arg Ile Gln Tyr 
        915                 920                 925             


Tyr Asp Asp Ile Val Arg Thr Leu Glu Phe Ser Ala Gln Tyr Ile Gly 
    930                 935                 940                 


Lys Ile Ser Asn Asn Ile Asn Asp Tyr Phe Asn Ser Glu Asp Glu Tyr 
945                 950                 955                 960 


Val Ser Phe Leu Ser Lys Tyr Val Gly Phe Ile Asn Asp Lys Ser Glu 
                965                 970                 975     


Asp Val Leu Thr Glu Leu Lys Asp Phe Cys Arg Glu Lys Ile Asn Asn 
            980                 985                 990         


Gly Ser Gln Ile Ile Gly Ile Tyr  Tyr Gly Gly Asp Asn  Val Ile Ile 
        995                 1000                 1005             


Asn Arg  Asn Val Ile Tyr Ala  Gln Met Tyr Ser Asn  Ala Glu Val 
    1010                 1015                 1020             


Phe Ser  Asn Ile Tyr Lys Lys  Val Thr Lys Asn Asp  Ile Ile Asn 
    1025                 1030                 1035             


Tyr Tyr  Glu Lys Gln Asn Asp  Leu Lys Asp Val Phe  Lys Ser Gly 
    1040                 1045                 1050             


Val Cys  Gln Asn Glu Gly Glu  Gln Arg Ser Leu Cys  Glu Phe Gln 
    1055                 1060                 1065             


Gln Leu  Lys Asn Arg Ile Glu  Leu Thr Glu Leu Ser  Thr Tyr Ala 
    1070                 1075                 1080             


Asp Met  Val Asn Asp Phe Met  Ala Gln Phe Val Glu  Trp Ala Tyr 
    1085                 1090                 1095             


Leu Arg  Glu Arg Asp Leu Met  Tyr Phe Gln Leu Gly  Ile His Tyr 
    1100                 1105                 1110             


Ile Arg  Leu Phe Tyr Ser Asp  Asn Val Leu Asp Glu  Lys Tyr His 
    1115                 1120                 1125             


Lys Leu  Ser Asp Asn Val Ile  Asp Ile Glu Glu Gly  Ala Leu Leu 
    1130                 1135                 1140             


Tyr Gln  Ile Val Ala Met Tyr  Asp Tyr Glu Leu Arg  Ile Phe Glu 
    1145                 1150                 1155             


Thr Asp  Asn Ser Gly Asn Ala  Lys Arg Ile Gly Gln  Gly Gly Pro 
    1160                 1165                 1170             


Gly Lys  Ser Ile Pro Val Phe  Leu Lys Lys Tyr Cys  Asn Gly Thr 
    1175                 1180                 1185             


Asp Val  Tyr Glu Cys Gly Leu  Glu Leu Phe Glu Asp  Ile Asn Gln 
    1190                 1195                 1200             


His Glu  His Ile Ile Arg Phe  Arg Asn Asp Ile Ala  His Met Arg 
    1205                 1210                 1215             


Tyr Met  Ser Asn Gln Ala Met  Asn Ile Met Ser Ile  Val Ser Asn 
    1220                 1225                 1230             


Ile Tyr  Lys Ser Phe Phe Val  Tyr Asp Thr Lys Leu  Lys Lys Ser 
    1235                 1240                 1245             


Ile Ser  Leu Val Phe Lys Asn  Ile Leu Met Arg Tyr  Gly Val Ile 
    1250                 1255                 1260             


Ala Asp  Leu Val Phe Ser Tyr  Asn Asn Lys Asn Gln  Ser Ile Lys 
    1265                 1270                 1275             


Asp Asp  Met Asp Ile Asn Ile  Ile Asn Ile Lys Asn  Leu Lys Ser 
    1280                 1285                 1290             


Asp Lys  Tyr Val Tyr Lys Ile  Val Asn Glu Asp Ile  Val Lys Gln 
    1295                 1300                 1305             


Val Glu  Ile Glu Ile Arg Asn  Gln Val Phe Leu Glu  Gln Leu His 
    1310                 1315                 1320             


Asn Leu  Leu Tyr Phe Ser Arg  
    1325                 1330 


<210>  823
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  823

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Thr Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Asp Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Ser Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val His Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1400                 1405                 1410         


<210>  824
<211>  1330
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  824

Met Lys Arg Glu Lys Asn Ile Thr Ile Met Lys Ile Ser Lys Val Asn 
1               5                   10                  15      


His Arg Arg Thr Ala Val Ala Leu Asn Gly Asp Lys Ser Glu Leu Gly 
            20                  25                  30          


Gly Ile Leu Tyr Glu Ala Pro Val Gln Lys Asp Lys Asn Gly Asn Tyr 
        35                  40                  45              


Asn Asp Val Ile Ala Glu Thr Gly Lys Val Val Asn Glu Ala Leu Asp 
    50                  55                  60                  


Lys Lys Ser Arg Leu Tyr Thr Pro Phe Asn Asn Gln Lys Val Ile Ile 
65                  70                  75                  80  


Asp Lys Asn Leu Gln Arg Tyr Ala Asn Asn Leu Lys Arg Cys Tyr Ile 
                85                  90                  95      


Asn Phe Val Lys Gln Tyr Val Asn Asn Lys Ser Phe Asn Tyr Lys Ala 
            100                 105                 110         


Met Gln Phe Ile Pro Asp Ile Gln Asn Leu Lys Thr Asn Asp Ala Val 
        115                 120                 125             


Asn Tyr Arg Thr Asp Arg Asp Asn Val Tyr Asn Lys Asn Lys Tyr Tyr 
    130                 135                 140                 


Asp Lys Gln Thr Lys Ser Lys Ser Lys Lys Phe Ile Tyr Glu Lys Ile 
145                 150                 155                 160 


Val Ile Pro Gln Asn Glu Gln Asn Ile Val Ile Ser Ala Leu Val Asn 
                165                 170                 175     


Cys Ser Leu Arg Lys Ser Leu Arg Lys Asp Val Ser Tyr Lys Thr Lys 
            180                 185                 190         


Ser Gly Glu Ile Lys Thr Tyr Asn Leu Pro Glu Leu Val Lys Lys Ser 
        195                 200                 205             


Met Arg Phe Tyr Cys Leu Glu Gly Gln Arg Glu Pro Asp Glu Lys Glu 
    210                 215                 220                 


Lys Tyr Glu Met Tyr Ile Leu Phe Ser Tyr Met Lys Glu Asp Lys Arg 
225                 230                 235                 240 


Thr Lys Asn Thr Asp Leu Leu Val Lys Ser Ile Ser Asn Gln Asn Thr 
                245                 250                 255     


Lys Val Lys Val Glu Asp Ile Asp Gly Asn Lys Leu Leu Lys Leu Ser 
            260                 265                 270         


Ile Ala Asp Thr Lys Lys Lys Pro Leu Trp Glu Tyr Leu Ile Lys Tyr 
        275                 280                 285             


Ala Asp Ser Ser Arg Gln Arg Glu Leu Met Tyr Asp Ile Arg Lys Lys 
    290                 295                 300                 


Ile Ile Leu Tyr Val Ala Gly Ile Glu Glu Tyr Glu Asn Ile Lys Glu 
305                 310                 315                 320 


Asp Ser Gly Leu Ser Lys Val Ser Trp Ser Lys Tyr Asn Ile Ser Asp 
                325                 330                 335     


Asn Lys Met Phe Leu Asp Ile Asn Ser Cys Thr Asp Lys Arg Lys Gln 
            340                 345                 350         


Asn Leu Glu Ile Lys Ile Arg Glu Ala Asn Ile Glu His Tyr Arg Asn 
        355                 360                 365             


Ala Ser Ser Lys Leu Cys Asp Asp Glu Ser Ile Phe Trp Phe Gln His 
    370                 375                 380                 


Phe Glu Gly Val Ile Glu Thr Leu Phe Ser Lys Lys Ser Lys Ile Ser 
385                 390                 395                 400 


Glu Glu Arg Leu Gly Cys Ala Tyr Ile Cys Asp Tyr Leu Trp Lys Asp 
                405                 410                 415     


Phe Leu Ser Tyr Leu Ala Ala Lys Tyr Ile Asp Leu Gly Lys Gly Val 
            420                 425                 430         


Tyr His Phe Thr Met Lys Asp Lys Leu Asp Met Leu Asn Lys Asn Glu 
        435                 440                 445             


Ala Val Thr Asp Leu Arg Phe Gly Ile Val Ser Glu Lys Tyr Glu Lys 
    450                 455                 460                 


Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Glu Leu 
465                 470                 475                 480 


Asp Arg Asn Ile Ala Ala Tyr Val Thr Phe Ala Ala Asp Ile Phe Ala 
                485                 490                 495     


Lys Ser Val Ile Lys Ser Asp Tyr Arg Thr Lys Lys Asp Asn Asn Ser 
            500                 505                 510         


Asp Val Leu Gln Tyr Ser Asp Lys Glu Phe Arg Asn Ser Glu Val Ile 
        515                 520                 525             


Arg Asp Asn Ala Glu Lys Asn Ile Leu Gln Tyr Trp Gly Gly Tyr Ser 
    530                 535                 540                 


Arg Trp Gly Thr Glu Asn Ser Lys Leu Pro Glu Asn Asn Lys Val Ser 
545                 550                 555                 560 


Asp Phe Gly Lys Leu Asp Val Ser Asp Leu Cys Ile Asp Ile Lys Lys 
                565                 570                 575     


His Leu Ala Gly Ile Arg Asn Ser Ser Val His Tyr Thr Thr Lys Ile 
            580                 585                 590         


Lys Asn Glu Ser Ala Ala Asp Gly Ser Asn Val Lys Ile Leu Phe Glu 
        595                 600                 605             


Lys Asp Leu Ala Asp Ile Asn Ile Ile Tyr Ala Asp Lys Tyr Tyr Ser 
    610                 615                 620                 


Asn Asn Val Trp Met Phe Tyr Ser Leu Glu Asp Ile Asn Lys Leu Ile 
625                 630                 635                 640 


Ala Phe Leu Tyr Lys Glu Lys Arg Val Ile Arg Gln Val Gln Ile Pro 
                645                 650                 655     


Ser Phe Ser Arg Ile Leu Lys Arg Lys Ala Met Gln Asp Val Ile Asn 
            660                 665                 670         


Glu Ile Phe Lys Asp Asp Phe Asp Glu Asn Ile Val Asn Pro Glu Leu 
        675                 680                 685             


Lys Glu Lys Tyr Arg Asn Ser Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
    690                 695                 700                 


Tyr Asn Ala Phe Ile Ile Gln Pro Glu Leu Lys Glu Lys Phe Lys Asp 
705                 710                 715                 720 


Lys Ile Lys Thr Met Lys Ser Glu Leu Tyr Asn Lys Leu Lys Thr Ile 
                725                 730                 735     


Asp Lys Lys Glu Tyr Lys Ala Leu Tyr Cys Met Leu Ser Asn Glu Glu 
            740                 745                 750         


Ser Ala Leu Lys Asn Phe Ala Asp Arg Ile Tyr Ser Val Asp Gly Asp 
        755                 760                 765             


Asn Val Ser Phe Ala Asp Ile Cys Lys Ile Leu Met Thr Asp Tyr Asn 
    770                 775                 780                 


Met Gln Asn Gln Glu Lys Lys Asn Ile Glu Ser Met Glu Gln Lys Lys 
785                 790                 795                 800 


Lys Asn Lys Gly Lys Asp Glu Asn Tyr Lys His Phe Pro Leu Leu Leu 
                805                 810                 815     


His Lys Val Leu Lys Glu Leu Phe Ile Glu Tyr Leu Lys Gln Thr His 
            820                 825                 830         


Glu Leu Glu Phe Leu Arg Asn Asn Ile Cys Ile Lys Ser Asp Val Thr 
        835                 840                 845             


Met Glu Ser Phe Glu Ser Gln Ile Lys Gly Val Glu Ile Tyr Lys Asp 
    850                 855                 860                 


Leu Lys Glu Lys Ile Asp Lys Asn Asn Ser Leu Leu Asp Trp Tyr Val 
865                 870                 875                 880 


Ile Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asn 
                885                 890                 895     


Ile Lys Asn Tyr Ile Gln Phe Ala Thr Asn Ile Asp Lys Arg Ala Glu 
            900                 905                 910         


Ser Val Lys Asn Leu Thr Glu Ser Gly Met Val Lys Arg Ile Gln Tyr 
        915                 920                 925             


Tyr Asp Asp Ile Val Arg Thr Leu Glu Phe Ser Ala Gln Tyr Ile Gly 
    930                 935                 940                 


Lys Ile Ser Asn Asn Ile Asn Asp Tyr Phe Asn Ser Glu Asp Glu Tyr 
945                 950                 955                 960 


Val Ser Phe Leu Ser Lys Tyr Val Gly Phe Ile Asn Asp Lys Ser Glu 
                965                 970                 975     


Asp Val Leu Thr Glu Leu Lys Asp Phe Cys Arg Glu Lys Ile Asn Asn 
            980                 985                 990         


Gly Ser Gln Ile Ile Gly Ile Tyr  Tyr Gly Gly Asp Asn  Val Ile Ile 
        995                 1000                 1005             


Asn Arg  Asn Val Ile Tyr Ala  Gln Met Tyr Ser Asn  Ala Glu Val 
    1010                 1015                 1020             


Phe Ser  Asn Ile Tyr Lys Lys  Val Thr Lys Asn Asp  Ile Ile Asn 
    1025                 1030                 1035             


Tyr Tyr  Glu Lys Gln Asn Asp  Leu Lys Asp Val Phe  Lys Ser Gly 
    1040                 1045                 1050             


Val Cys  Gln Asn Glu Gly Glu  Gln Arg Ser Leu Cys  Glu Phe Gln 
    1055                 1060                 1065             


Gln Leu  Lys Asn Arg Ile Glu  Leu Thr Glu Leu Ser  Thr Tyr Ala 
    1070                 1075                 1080             


Asp Met  Val Asn Asp Phe Met  Ala Gln Phe Val Glu  Trp Ala Tyr 
    1085                 1090                 1095             


Leu Arg  Glu Arg Asp Leu Met  Tyr Phe Gln Leu Gly  Ile His Tyr 
    1100                 1105                 1110             


Ile Arg  Leu Phe Tyr Ser Asp  Asn Val Leu Asp Glu  Lys Tyr His 
    1115                 1120                 1125             


Lys Leu  Arg Asp Asn Val Ile  Asp Ile Glu Glu Gly  Ala Leu Leu 
    1130                 1135                 1140             


Tyr Gln  Ile Val Ala Met Tyr  Asp Tyr Glu Leu Arg  Ile Phe Glu 
    1145                 1150                 1155             


Thr Asp  Asn Ser Gly Asn Ala  Lys Arg Ile Gly Gln  Gly Gly Pro 
    1160                 1165                 1170             


Gly Lys  Ser Ile Pro Val Phe  Leu Lys Lys Tyr Cys  Asn Gly Thr 
    1175                 1180                 1185             


Asp Val  Tyr Glu Cys Gly Leu  Glu Leu Phe Glu Asp  Ile Asn Gln 
    1190                 1195                 1200             


His Glu  His Ile Ile Arg Phe  Arg Asn Asp Ile Ala  His Met Arg 
    1205                 1210                 1215             


Tyr Met  Ser Asn Gln Ala Met  Asn Ile Met Ser Ile  Val Ser Asn 
    1220                 1225                 1230             


Ile Tyr  Lys Ser Phe Phe Val  Tyr Asp Thr Lys Leu  Lys Lys Ser 
    1235                 1240                 1245             


Ile Ser  Leu Val Phe Lys Asn  Ile Leu Met Arg Tyr  Gly Val Ile 
    1250                 1255                 1260             


Ala Asp  Leu Val Phe Ser Tyr  Asn Asn Lys Asn Gln  Ser Ile Lys 
    1265                 1270                 1275             


Asp Asp  Met Asn Ile Asn Ile  Ile Asn Ile Lys Asn  Leu Lys Ser 
    1280                 1285                 1290             


Asp Lys  Tyr Val Tyr Lys Ile  Val Asn Glu Asp Ile  Val Lys Gln 
    1295                 1300                 1305             


Val Glu  Ile Glu Ile Arg Asn  Gln Val Phe Leu Glu  Gln Leu His 
    1310                 1315                 1320             


Lys Leu  Leu Tyr Phe Ser Arg  
    1325                 1330 


<210>  825
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  825

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Pro Gly Thr Asp Thr 
            20                  25                  30          


Ile Gly Leu Lys Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Asp Lys Pro Lys Lys 
    50                  55                  60                  


Trp Lys Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Glu Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Ser Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Met Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Tyr Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ser Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Lys Asp Arg Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Lys Glu Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Gln Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Phe 
            660                 665                 670         


Ile Arg Lys Asn Phe Pro Glu Asp Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Asp Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Asp Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asn  Ser Glu Lys Lys Glu  Ala Tyr Gln Lys Ile  Glu Val Asn 
    1100                 1105                 1110             


Gly Asp  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Val  Tyr Ala Pro Asp Glu  Lys Gly Asp 
    1130                 1135                 1140             


Ile Leu  Lys Glu Gln Cys Thr  Lys Gly Gly Ala Gly  Gly Lys Ile 
    1145                 1150                 1155             


Ser Ala  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Lys Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Lys Gln 
    1250                 1255                 1260             


Thr Thr  Ser Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Ser Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Lys  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Val Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Gly Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Pro Asn 
    1370                 1375                 1380         


<210>  826
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  826

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Ile Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Phe Asp Phe Lys Leu  Leu Asn 
    1400                 1405                 1410         


<210>  827
<211>  1330
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  827

Met Lys Arg Glu Lys Asn Ile Thr Ile Met Lys Ile Ser Lys Val Asn 
1               5                   10                  15      


His Arg Arg Met Ala Val Ala Leu Asn Gly Asp Lys Ser Glu Leu Gly 
            20                  25                  30          


Gly Ile Leu Tyr Glu Ala Pro Val Gln Lys Asp Lys Asn Gly Asn Tyr 
        35                  40                  45              


Asn Asp Val Ile Ala Glu Thr Gly Lys Val Val Asn Glu Ala Leu Asp 
    50                  55                  60                  


Lys Lys Ser Arg Leu Tyr Thr Pro Phe Asn Asn Gln Lys Val Ile Ile 
65                  70                  75                  80  


Asp Lys Asn Leu Gln Arg Tyr Ala Asn Asn Leu Lys Arg Cys Tyr Ile 
                85                  90                  95      


Asn Phe Val Lys Gln Tyr Val Asn Asn Lys Ser Phe Asn Tyr Lys Ala 
            100                 105                 110         


Met Gln Phe Ile Pro Asp Ile Gln Asn Pro Lys Thr Asn Asp Ala Val 
        115                 120                 125             


Asn Tyr Arg Thr Asp Arg Asp Asn Val Tyr Asn Lys Asn Lys Tyr Tyr 
    130                 135                 140                 


Asp Lys Gln Thr Lys Ser Lys Ser Lys Lys Phe Ile Tyr Glu Lys Ile 
145                 150                 155                 160 


Val Ile Pro Gln Asn Glu Gln Asn Ile Val Ile Ser Ala Leu Val Asn 
                165                 170                 175     


Cys Ser Leu Arg Lys Ser Leu Arg Lys Asp Val Ser Tyr Lys Thr Lys 
            180                 185                 190         


Ser Gly Glu Ile Lys Thr Tyr Asn Leu Pro Glu Leu Val Lys Lys Ser 
        195                 200                 205             


Met Arg Phe Tyr Cys Leu Glu Gly Gln Arg Glu Pro Asp Glu Lys Glu 
    210                 215                 220                 


Lys Tyr Glu Met Tyr Ile Leu Phe Ser Tyr Met Lys Glu Asp Lys Arg 
225                 230                 235                 240 


Thr Lys Asn Thr Asp Leu Leu Val Lys Ser Ile Ser Asn Gln Asn Thr 
                245                 250                 255     


Lys Val Lys Val Glu Asp Ile Asp Gly Asn Lys Leu Leu Lys Leu Ser 
            260                 265                 270         


Ile Ala Asp Thr Lys Lys Glu Pro Leu Trp Glu Tyr Leu Ile Lys Tyr 
        275                 280                 285             


Ala Asp Ser Ser Arg Gln Arg Glu Leu Met Tyr Asp Ile Arg Lys Lys 
    290                 295                 300                 


Ile Val Leu Tyr Val Val Gly Ile Glu Glu Tyr Glu Asn Ile Lys Glu 
305                 310                 315                 320 


Asp Ser Gly Leu Ser Lys Val Ser Trp Ser Lys Tyr Asn Ile Ser Asp 
                325                 330                 335     


Asn Lys Met Phe Phe Asp Ile Asn Ser Cys Thr Asp Lys Arg Lys Gln 
            340                 345                 350         


Asn Leu Glu Ile Lys Ile Arg Glu Ala Asn Ile Glu His Tyr Arg Asn 
        355                 360                 365             


Ala Ser Ser Lys Leu Cys Asp Asp Gln Ser Ile Phe Trp Phe Gln His 
    370                 375                 380                 


Phe Glu Gly Val Ile Glu Thr Leu Phe Ser Lys Lys Ser Lys Ile Ser 
385                 390                 395                 400 


Glu Glu Arg Leu Gly Cys Ala Tyr Ile Cys Asp Tyr Leu Trp Lys Asp 
                405                 410                 415     


Phe Leu Ser Tyr Leu Ala Ala Lys Tyr Ile Asp Leu Gly Lys Gly Val 
            420                 425                 430         


Tyr His Phe Thr Met Lys Asp Lys Leu Asp Met Leu Asn Lys Asn Glu 
        435                 440                 445             


Ala Val Thr Asp Leu Arg Phe Gly Ile Val Ser Glu Lys Tyr Glu Lys 
    450                 455                 460                 


Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Glu Leu 
465                 470                 475                 480 


Asp Arg Asn Ile Ala Ala Tyr Val Thr Phe Ala Ala Asp Ile Phe Ala 
                485                 490                 495     


Lys Ser Val Ile Lys Ser Asp Tyr Arg Thr Lys Lys Asp Asn Asn Ser 
            500                 505                 510         


Asp Val Leu Gln Tyr Ser Asp Lys Glu Phe Arg Asn Ser Glu Val Ile 
        515                 520                 525             


Arg Asp Asn Ala Glu Lys Asn Ile Leu Gln Tyr Trp Gly Gly Tyr Ser 
    530                 535                 540                 


Arg Trp Gly Thr Glu Asn Ser Lys Leu Pro Glu Asn Asn Lys Val Ser 
545                 550                 555                 560 


Asp Phe Gly Lys Leu Asp Val Ser Asp Leu Cys Ile Asp Ile Lys Lys 
                565                 570                 575     


His Leu Ala Gly Ile Arg Asn Ser Ser Val His Tyr Thr Thr Lys Ile 
            580                 585                 590         


Lys Asn Glu Ser Ala Ala Asp Gly Ser Asn Val Lys Ile Leu Phe Glu 
        595                 600                 605             


Lys Asp Leu Ala Asp Ile Asn Ile Ile Tyr Ala Asp Lys Tyr Tyr Ser 
    610                 615                 620                 


Asn Asn Val Trp Met Phe Tyr Ser Leu Glu Asp Ile Asn Lys Leu Ile 
625                 630                 635                 640 


Ala Phe Leu Tyr Lys Glu Lys Arg Val Ile Arg Gln Val Gln Ile Pro 
                645                 650                 655     


Ser Phe Ser Arg Ile Leu Lys Arg Lys Ala Met Gln Asp Val Ile Asn 
            660                 665                 670         


Glu Ile Phe Lys Asp Asp Phe Asp Glu Asn Ile Val Asn Pro Glu Leu 
        675                 680                 685             


Lys Glu Lys Tyr Arg Asn Ser Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
    690                 695                 700                 


Tyr Asn Ala Phe Ile Ile Gln Pro Glu Leu Lys Glu Lys Phe Lys Asp 
705                 710                 715                 720 


Lys Ile Lys Thr Met Lys Ser Glu Leu Tyr Asn Lys Leu Lys Thr Ile 
                725                 730                 735     


Asp Lys Lys Glu Tyr Lys Ala Leu Tyr Cys Met Leu Ser Asn Glu Glu 
            740                 745                 750         


Ser Ala Leu Lys Asn Phe Ala Asp Arg Ile Tyr Ser Val Asp Gly Asp 
        755                 760                 765             


Asn Val Ser Phe Ala Asp Ile Cys Lys Ile Leu Met Thr Asp Tyr Asn 
    770                 775                 780                 


Met Gln Asn Gln Glu Lys Lys Asn Ile Glu Ser Met Glu Gln Lys Lys 
785                 790                 795                 800 


Lys Asn Lys Gly Lys Asp Glu Asn Tyr Lys His Phe Pro Leu Leu Leu 
                805                 810                 815     


His Lys Val Leu Lys Glu Leu Phe Ile Glu Tyr Leu Lys Gln Thr His 
            820                 825                 830         


Glu Leu Glu Phe Leu Arg Asn Asn Ile Cys Ile Lys Ser Asp Val Thr 
        835                 840                 845             


Met Glu Ser Phe Glu Ser Gln Ile Lys Gly Val Glu Ile Tyr Lys Asp 
    850                 855                 860                 


Leu Lys Glu Lys Ile Asp Lys Asn Asn Ser Leu Leu Asp Trp Tyr Val 
865                 870                 875                 880 


Ile Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asn 
                885                 890                 895     


Ile Lys Asn Tyr Ile Gln Phe Ala Thr Asn Ile Asp Lys Arg Ala Glu 
            900                 905                 910         


Ser Val Lys Asn Leu Thr Glu Ser Gly Met Val Lys Arg Ile Gln Tyr 
        915                 920                 925             


Tyr Asp Asp Ile Val Arg Thr Leu Glu Phe Ser Ala Gln Tyr Ile Gly 
    930                 935                 940                 


Lys Ile Ser Asn Asn Ile Asn Asp Tyr Phe Asn Ser Glu Asp Glu Tyr 
945                 950                 955                 960 


Val Ser Phe Leu Ser Lys Tyr Val Gly Phe Ile Asn Asp Lys Ser Glu 
                965                 970                 975     


Asp Val Leu Thr Glu Leu Lys Asp Phe Cys Arg Glu Lys Ile Asn Asn 
            980                 985                 990         


Gly Ser Gln Ile Ile Gly Ile Tyr  Tyr Gly Gly Asp Asn  Val Ile Ile 
        995                 1000                 1005             


Asn Arg  Asn Val Ile Tyr Ala  Gln Met Tyr Ser Asn  Ala Glu Val 
    1010                 1015                 1020             


Phe Ser  Asn Ile Tyr Lys Lys  Val Thr Lys Asn Asp  Ile Ile Asn 
    1025                 1030                 1035             


Tyr Tyr  Glu Lys Gln Asn Asp  Leu Lys Asp Val Phe  Lys Arg Gly 
    1040                 1045                 1050             


Val Cys  Gln Asn Glu Gly Glu  Gln Arg Ser Leu Cys  Glu Phe Gln 
    1055                 1060                 1065             


Gln Leu  Lys Asn Arg Ile Lys  Leu Thr Glu Leu Ser  Thr Tyr Ala 
    1070                 1075                 1080             


Asp Met  Val Asn Asp Phe Met  Ala Gln Phe Val Glu  Trp Ala Tyr 
    1085                 1090                 1095             


Leu Arg  Glu Arg Asp Leu Met  Tyr Phe Gln Leu Gly  Ile His Tyr 
    1100                 1105                 1110             


Ile Arg  Leu Phe Tyr Ser Asp  Asn Val Leu Asp Glu  Lys Tyr His 
    1115                 1120                 1125             


Lys Leu  Ser Asp Asn Val Ile  Asp Ile Glu Glu Gly  Ala Leu Leu 
    1130                 1135                 1140             


Tyr Gln  Ile Val Ala Met Tyr  Asp Tyr Glu Leu Arg  Ile Phe Glu 
    1145                 1150                 1155             


Thr Asp  Asn Ser Gly Asn Ala  Lys Arg Ile Gly Gln  Gly Gly Pro 
    1160                 1165                 1170             


Gly Lys  Ser Ile Pro Val Phe  Leu Lys Lys Tyr Cys  Asn Gly Thr 
    1175                 1180                 1185             


Asp Val  Tyr Glu Cys Gly Leu  Glu Leu Phe Glu Asp  Ile Asn Gln 
    1190                 1195                 1200             


His Glu  His Ile Ile Arg Phe  Arg Asn Asp Ile Ala  His Met Arg 
    1205                 1210                 1215             


Tyr Met  Ser Asn Gln Ala Met  Asn Ile Met Ser Ile  Val Ser Asn 
    1220                 1225                 1230             


Ile Tyr  Lys Ser Phe Phe Val  Tyr Asp Thr Lys Leu  Lys Lys Ser 
    1235                 1240                 1245             


Ile Ser  Leu Val Phe Lys Asn  Ile Leu Met Arg Tyr  Gly Val Ile 
    1250                 1255                 1260             


Ala Asp  Leu Val Phe Ser Tyr  Asn Asn Lys Asn Gln  Ser Ile Lys 
    1265                 1270                 1275             


Asp Asp  Met Asp Ile Asn Ile  Ile Asn Ile Lys Asn  Leu Lys Ser 
    1280                 1285                 1290             


Asp Lys  Tyr Val Tyr Lys Ile  Val Asn Glu Asp Ile  Val Lys Gln 
    1295                 1300                 1305             


Val Glu  Ile Glu Ile Arg Asn  Gln Val Phe Leu Glu  Gln Leu His 
    1310                 1315                 1320             


Asn Leu  Leu Tyr Phe Ser Arg  
    1325                 1330 


<210>  828
<211>  1315
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  828

Met Ile Ile Ile Lys Lys Phe Gly Arg Ser Val Ile Thr Gln Asp Lys 
1               5                   10                  15      


Asn Thr Asp Asn Lys Arg Glu Arg Glu Leu Asp Thr Ser Ala Arg Ala 
            20                  25                  30          


Lys Ala Lys Ser Gln Asn Ser Gln Val Phe Pro Phe Leu Asn Lys Lys 
        35                  40                  45              


Glu Asp Phe Ile Asn Leu Trp Ile Ser Glu Phe Asp Lys Leu Ile Tyr 
    50                  55                  60                  


Lys Pro Lys Gly Asp Asp Lys Pro Thr Lys Glu Met Tyr Thr Leu Arg 
65                  70                  75                  80  


Glu Ala Ala Gly Lys Gly Phe Leu Asn Tyr Trp Asn Gln Met Pro Met 
                85                  90                  95      


Val Ser Lys Lys Asp Gly Ala Phe Ser Asp Met Trp Met Ser Lys Val 
            100                 105                 110         


His Pro Tyr Gly Arg Gly Ile Thr Glu Phe Ser Pro Pro Leu Gln Leu 
        115                 120                 125             


Glu Lys Leu Ile Asp Gln Gly Leu Leu Ser Ala Met Gly Gly Ser Glu 
    130                 135                 140                 


Pro Leu Lys Asn Cys His Trp Asn Arg Val Thr Ser Asn Val Phe Lys 
145                 150                 155                 160 


Gly Leu Lys Val Gln Leu Asp Ile Leu Glu Ala Gln Ala Lys Asn Thr 
                165                 170                 175     


Phe Val Ile Lys Asn Lys Thr Asn Ser Lys Arg Asn Arg Pro Ala Ser 
            180                 185                 190         


Gln Asn Ile Lys Glu Phe Leu Leu Thr Asp Glu Thr Ala Phe Ile Asn 
        195                 200                 205             


Leu Trp Ile Ser Glu Phe Asp Lys Leu Ile Leu Lys Pro Gln Gly His 
    210                 215                 220                 


Asn Lys Pro Thr Glu Lys Met Tyr Asn Leu Arg Gln Gln Ala Gly Val 
225                 230                 235                 240 


Ala Phe Leu Asn Tyr Trp Lys Lys Lys Pro Leu Ile Pro Trp Ala Asn 
                245                 250                 255     


Ser Glu Ser Phe Pro Asp Lys Trp Met Leu Lys Val His Pro Tyr Gly 
            260                 265                 270         


Asp Lys Thr Ser Asn Asn Arg Ser Glu Thr Leu Ile Lys Ser Lys Trp 
        275                 280                 285             


Gly Ser Val Met Arg Ala Lys Glu Cys Leu Ser Asp Asp Gln Trp Glu 
    290                 295                 300                 


Gln Val Ala Phe Asn Val Tyr Ser His Leu Tyr Gly Asn Gln Lys Thr 
305                 310                 315                 320 


Leu Asn Gly Lys Asn Lys Glu Ile Gly Leu Ile Ala Ala Arg Ala Asn 
                325                 330                 335     


Ser Ile Lys Gln Asn Val Pro Ser Tyr Thr Leu Asp Lys Asp Asn Asn 
            340                 345                 350         


Phe Leu Ser Asp Lys Lys Asp Lys Leu Arg Tyr Ile Ala Ala Leu Arg 
        355                 360                 365             


Gly Glu Gly Ile Lys Trp Glu Glu Val Lys Asp Arg Tyr Lys Trp Lys 
    370                 375                 380                 


Glu Leu Thr Gln Leu Ile Asn Ile Glu Glu Ile Asp Ser Thr Asp Ile 
385                 390                 395                 400 


Ala Lys Arg Lys Gln His Leu Ala Glu Cys Phe Tyr Thr His His Gly 
                405                 410                 415     


Arg Ile Phe Gly Asp Ile Gln Asn Ser Lys Ile Glu Asp Lys Asp Cys 
            420                 425                 430         


Phe Leu Tyr His Ser Leu Val Lys Glu Ile Leu Phe Glu Cys Ile Glu 
        435                 440                 445             


Lys Lys Gln Asp Phe Leu Asn Asp Thr Glu Val His Gln Arg Leu Ile 
    450                 455                 460                 


Tyr Lys Glu Asn Asn Arg Ile Met Ala Thr Ala Val Ser Ile Gly Lys 
465                 470                 475                 480 


Leu Ile His Tyr Gln Gly Gly Ile Glu Ala Ile Gly Asn Lys Glu Asp 
                485                 490                 495     


Leu Val Asn Ser Lys Phe Leu Thr Asp Ala Gly Leu Thr Glu Ile Lys 
            500                 505                 510         


Gln Asn Glu Ser Phe Val Arg Gln Trp Leu Glu Leu Ile Ala Ile Ala 
        515                 520                 525             


Asn Thr Thr Leu Ser Gln Leu Val Asp Pro Asp Gly Lys His Glu Asp 
    530                 535                 540                 


Ile Phe Ala Ala Thr Ser Phe Asp Asp Ala Leu Lys Gly Leu Asn Asn 
545                 550                 555                 560 


Ile Ser Asp Phe Asp Ser Lys Phe Lys Leu Leu Phe Gly Glu Asn His 
                565                 570                 575     


Arg Leu Tyr Asp Asp Asp Thr Glu Arg Gln Lys Leu Leu Arg Ile Ile 
            580                 585                 590         


Tyr Asp Thr Ile Ser Ala Leu Arg Asn Ala Ser Phe His Phe Lys Asn 
        595                 600                 605             


Ile Gln Gly Phe Asn Lys Ala Leu Glu Asp Asn Leu Ser Thr Lys Gly 
    610                 615                 620                 


Arg Arg Gln Lys Gly Val Val Asp Lys Ile Ile Glu Tyr Thr Lys Val 
625                 630                 635                 640 


His Gln Gln Lys Gln His Glu Leu Leu Ile Ala Asp Leu Lys Ala Ala 
                645                 650                 655     


Asn Val Glu Asp Tyr Leu Ser Gln Leu Gln Leu Asp Tyr Leu Phe Glu 
            660                 665                 670         


Val Val Cys Lys Gly Glu Arg Glu Leu Leu Asp Met Pro Lys Phe Ser 
        675                 680                 685             


Lys Leu Leu Leu Arg Ala Gly Glu Ile Gly Glu Lys Ile Ile Ser Pro 
    690                 695                 700                 


Val Asn Ala Thr Ala Met Glu His Pro Ala Tyr Gln Cys Cys Phe Ile 
705                 710                 715                 720 


Ser Leu Lys Met Leu Tyr Asp Gln Asp Phe Val Asn Trp Leu Lys Lys 
                725                 730                 735     


Gln Ser Asn Lys Asn Ile Ala Ser Trp Met Asp Ser Ala Lys Thr Arg 
            740                 745                 750         


Ala Thr Asn Ala Ala Lys Lys Ile Phe Arg Asn Gly Thr Asn Ile Ser 
        755                 760                 765             


Ser Lys Met Ala Arg Leu Arg Asn Ile Val Glu Asp Glu Thr Leu Val 
    770                 775                 780                 


Glu Tyr Phe Ser Phe Ile Thr Ala Glu Thr Ala Asn Glu Phe Gln Val 
785                 790                 795                 800 


Gln Gln Gln Lys Asn Arg Tyr Gln Ser Asn Ser Ala Ser Ala Lys Glu 
                805                 810                 815     


Gln Ser Asn Phe Val Glu Gln Phe Lys Gln Asp Phe Leu Ile Tyr Ala 
            820                 825                 830         


Phe Lys Gly Tyr Ile Gly Asp Ile Lys Phe Gly Lys Leu Asp Gln Gly 
        835                 840                 845             


Glu Lys Leu Leu Lys Cys Asn Ala Lys Gly Ser Leu Leu Pro Glu Asn 
    850                 855                 860                 


Asn Arg Ser Asp Thr Gly Ala Glu Asp Ile Glu Arg Pro Trp Leu Tyr 
865                 870                 875                 880 


Leu Val Leu His Leu Val Pro Ile Glu Val Val Asn Arg Ile Thr Leu 
                885                 890                 895     


Gln Ile Lys Lys His Ser Val Leu Thr Asn Ser Thr Leu Asp Asp Thr 
            900                 905                 910         


Arg Ala Ala Tyr Thr Asp Ile His Gln Ala Phe Ser Leu Tyr Leu Gly 
        915                 920                 925             


Val His Gly Ala Ile Leu Gly Leu Gln Ser Leu Ser Asn Glu Pro Glu 
    930                 935                 940                 


Leu Gln Val Phe Phe Glu Lys Glu Ser Asp Phe Asn Asn Leu Phe Thr 
945                 950                 955                 960 


Asp Asn Gly Glu Gly Leu Val Pro Val Lys Gly Leu Arg Asp Ile Leu 
                965                 970                 975     


Arg Phe Gly Asn Leu Glu Gln Leu Lys Lys Met Phe Ser Asp Lys Lys 
            980                 985                 990         


Val Ala Ser Asp Asp Ile Thr Asn  Leu Lys Glu Tyr Leu  Glu Ala Thr 
        995                 1000                 1005             


Gly Gly  Lys Ser Lys Ile Ala  Arg Ala Gln Glu Lys  Arg Ile Glu 
    1010                 1015                 1020             


Leu His  Lys Thr Leu Thr Glu  Leu Pro Lys Arg Leu  Thr Lys Pro 
    1025                 1030                 1035             


Arg Val  Lys Gln Thr Gly Ile  Asp Thr Tyr Glu Lys  Asn Asn Asn 
    1040                 1045                 1050             


Ile Ser  Ile Ser Gly Ser Ile  Ser Glu Tyr Arg Lys  Asp Leu Lys 
    1055                 1060                 1065             


Cys Ile  Val Ser Tyr Arg Glu  Leu Lys Asn Lys Ile  Tyr Leu Tyr 
    1070                 1075                 1080             


Asn Val  Lys Gln Ala His Gln  Leu Ile Met Ala Thr  Gln Ala Arg 
    1085                 1090                 1095             


Leu Leu  Gly Tyr Ser Gln Ile  Arg Glu Arg Asp Leu  Tyr Phe Val 
    1100                 1105                 1110             


Leu Leu  Thr Gln Leu Met Leu  Arg Gly Val Thr Leu  Glu Lys Glu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Asp Lys Asp  Lys Leu Asn Ala Leu  Asp Thr Asp 
    1130                 1135                 1140             


Thr Val  Leu Asp Glu Glu Glu  Lys Lys Lys Leu Glu  Lys Gln Ile 
    1145                 1150                 1155             


Lys Pro  Glu Arg Ser Leu Lys  Asp Leu Val Glu Lys  Gly Leu Ile 
    1160                 1165                 1170             


Phe Leu  Ala Leu Asp Gln Leu  Ser Ser Ser Asp Lys  Asp Leu Lys 
    1175                 1180                 1185             


Ala Ile  His Ser Glu Ile Glu  Asp Met Phe Val Gly  Val Ser Pro 
    1190                 1195                 1200             


Asp Ser  Asp Asn Arg Asn Leu  Arg Asn Arg Leu Ala  His Phe Lys 
    1205                 1210                 1215             


Asp Leu  Gly Asn Lys Asn Leu  Ile Asn Ile Thr Ser  Gln Ile Asn 
    1220                 1225                 1230             


Glu Val  Arg Lys Met Met Ser  Tyr Asp Arg Lys Leu  Lys Asn Ala 
    1235                 1240                 1245             


Val Ser  Lys Ser Met Ile Asp  Leu Phe Glu Arg Tyr  Asn Leu Ile 
    1250                 1255                 1260             


Leu Ser  Phe Lys Val Gln Ser  His Lys Leu Gln Leu  Lys Asn Leu 
    1265                 1270                 1275             


Lys Ser  Lys Gln Ile Thr His  Leu Asn Asn Lys Gly  Ile Thr Glu 
    1280                 1285                 1290             


Asn Leu  Leu Ser Asp Asp Tyr  Val Ser Val Ile Lys  Arg Leu Leu 
    1295                 1300                 1305             


Leu Thr  Glu Gln Asn Pro Glu  
    1310                 1315 


<210>  829
<211>  1315
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  829

Met Ile Ile Ile Lys Lys Phe Gly Arg Ser Val Ile Thr Gln Asp Lys 
1               5                   10                  15      


Asn Thr Asp Asn Lys Arg Glu Arg Glu Leu Asp Thr Ser Ala Arg Ala 
            20                  25                  30          


Lys Ala Lys Ser Gln Asn Ser Gln Val Phe Pro Phe Leu Asn Lys Lys 
        35                  40                  45              


Glu Asp Phe Ile Asn Leu Trp Ile Ser Glu Phe Asp Lys Leu Ile Tyr 
    50                  55                  60                  


Lys Pro Lys Gly Asp Asp Lys Pro Thr Lys Glu Met Tyr Thr Leu Arg 
65                  70                  75                  80  


Glu Ala Ala Gly Lys Gly Phe Leu Asn Tyr Trp Asn Gln Met Pro Met 
                85                  90                  95      


Val Ser Lys Lys Asp Gly Ala Phe Ser Asp Met Trp Met Ser Lys Val 
            100                 105                 110         


His Pro Tyr Gly Arg Gly Ile Thr Glu Phe Ser Pro Pro Leu Gln Leu 
        115                 120                 125             


Glu Lys Leu Ile Asp Gln Gly Leu Leu Ser Ala Met Gly Gly Ser Glu 
    130                 135                 140                 


Pro Leu Lys Asn Cys His Trp Asn Arg Val Thr Ser Asn Val Phe Lys 
145                 150                 155                 160 


Gly Leu Lys Val Gln Leu Asp Ile Leu Glu Ala Gln Ala Lys Asn Thr 
                165                 170                 175     


Phe Val Ile Lys Asn Lys Thr Asn Ser Lys Arg Asn Arg Pro Ala Ser 
            180                 185                 190         


Gln Asn Ile Lys Glu Phe Leu Leu Thr Asp Glu Thr Ala Phe Ile Asn 
        195                 200                 205             


Leu Trp Ile Ser Glu Phe Asp Lys Leu Ile Leu Lys Pro Gln Gly His 
    210                 215                 220                 


Asn Lys Pro Thr Glu Lys Met Tyr Asn Leu Arg Gln Gln Ala Gly Val 
225                 230                 235                 240 


Ala Phe Leu Asn Tyr Trp Lys Lys Lys Pro Leu Ile Pro Trp Ala Asn 
                245                 250                 255     


Ser Glu Ser Phe Pro Asp Lys Trp Met Leu Lys Val His Pro Tyr Gly 
            260                 265                 270         


Asp Lys Thr Ser Asn Asn Arg Ser Glu Thr Leu Ile Lys Ser Lys Trp 
        275                 280                 285             


Gly Ser Val Met Arg Ala Lys Glu Cys Leu Ser Asp Asp Gln Trp Glu 
    290                 295                 300                 


Gln Val Ala Phe Asn Val Tyr Ser His Leu Tyr Gly Asn Gln Lys Thr 
305                 310                 315                 320 


Leu Asn Gly Lys Asn Lys Glu Ile Gly Leu Ile Ala Ala Arg Ala Asn 
                325                 330                 335     


Ser Ile Lys Gln Asn Val Pro Ser Tyr Thr Leu Asp Lys Asp Asn Asn 
            340                 345                 350         


Phe Leu Ser Asp Lys Lys Asp Lys Leu Arg Tyr Ile Ala Ala Leu Arg 
        355                 360                 365             


Gly Glu Gly Ile Lys Trp Glu Glu Val Lys Asp Arg Tyr Lys Trp Lys 
    370                 375                 380                 


Glu Leu Thr Gln Leu Ile Asn Ile Glu Glu Ile Asp Ser Thr Asp Ile 
385                 390                 395                 400 


Ala Lys Arg Lys Gln His Leu Ala Glu Cys Phe Tyr Thr His His Gly 
                405                 410                 415     


Arg Ile Phe Gly Asp Ile Gln Asn Ser Lys Ile Glu Asp Lys Asp Cys 
            420                 425                 430         


Phe Leu Tyr His Ser Leu Val Lys Glu Ile Leu Phe Glu Cys Ile Glu 
        435                 440                 445             


Lys Lys Gln Asp Phe Leu Asn Asp Thr Glu Val His Gln Arg Leu Ile 
    450                 455                 460                 


Tyr Lys Glu Asn Asn Arg Ile Met Ala Thr Ala Val Ser Ile Gly Lys 
465                 470                 475                 480 


Leu Ile His Tyr Gln Gly Gly Ile Glu Ala Ile Gly Asn Lys Glu Asp 
                485                 490                 495     


Leu Val Asn Ser Lys Phe Leu Thr Asp Ala Gly Leu Thr Glu Ile Lys 
            500                 505                 510         


Gln Asn Glu Ser Phe Val Arg Gln Trp Leu Glu Leu Ile Ala Ile Ala 
        515                 520                 525             


Asn Thr Thr Leu Ser Gln Leu Val Asp Pro Asp Gly Lys His Glu Asp 
    530                 535                 540                 


Ile Phe Ala Ala Thr Ser Phe Asp Asp Ala Leu Lys Gly Leu Asn Asn 
545                 550                 555                 560 


Ile Ser Asp Phe Asp Ser Lys Phe Lys Leu Leu Phe Gly Glu Asn His 
                565                 570                 575     


Arg Leu Tyr Asp Asp Asp Thr Glu Arg Gln Lys Leu Leu Arg Ile Ile 
            580                 585                 590         


Tyr Asp Thr Ile Ser Ala Leu Arg Asn Ala Ser Phe His Phe Lys Asn 
        595                 600                 605             


Ile Gln Gly Phe Asn Lys Ala Leu Glu Asp Asn Leu Ser Thr Lys Gly 
    610                 615                 620                 


Arg Arg Gln Lys Gly Val Val Asp Lys Ile Ile Glu Tyr Thr Lys Val 
625                 630                 635                 640 


His Gln Gln Lys Gln His Glu Leu Leu Ile Ala Asp Leu Lys Ala Ala 
                645                 650                 655     


Asn Val Glu Asp Tyr Leu Ser Gln Leu Gln Leu Asp Tyr Leu Phe Glu 
            660                 665                 670         


Val Val Cys Lys Gly Glu Arg Glu Leu Leu Asp Met Pro Lys Phe Ser 
        675                 680                 685             


Lys Leu Leu Leu Arg Ala Gly Glu Ile Gly Glu Lys Ile Ile Ser Pro 
    690                 695                 700                 


Val Asn Ala Thr Ala Met Glu His Pro Ala Tyr Gln Cys Cys Phe Ile 
705                 710                 715                 720 


Ser Leu Lys Met Leu Tyr Asp Gln Asp Phe Val Asn Trp Leu Lys Lys 
                725                 730                 735     


Gln Ser Asn Lys Asn Ile Ala Ser Trp Met Asp Ser Ala Lys Thr Arg 
            740                 745                 750         


Ala Thr Asn Ala Ala Lys Lys Ile Phe Arg Asn Gly Thr Asn Ile Ser 
        755                 760                 765             


Ser Lys Met Ala Arg Leu Arg Asn Ile Val Glu Asp Glu Thr Leu Val 
    770                 775                 780                 


Glu Tyr Phe Ser Phe Ile Thr Ala Glu Thr Ala Asn Glu Phe Gln Val 
785                 790                 795                 800 


Gln Gln Gln Lys Asn Arg Tyr Gln Ser Asn Ser Ala Ser Ala Lys Glu 
                805                 810                 815     


Gln Ser Asn Phe Val Glu Gln Phe Lys Gln Asp Phe Leu Ile Tyr Ala 
            820                 825                 830         


Phe Lys Gly Tyr Ile Gly Asp Ile Lys Phe Gly Lys Leu Asp Gln Gly 
        835                 840                 845             


Glu Lys Leu Leu Lys Cys Asn Ala Lys Gly Ser Leu Leu Pro Glu Asn 
    850                 855                 860                 


Asn Arg Ser Asp Thr Gly Ala Glu Asp Ile Glu Arg Pro Trp Leu Tyr 
865                 870                 875                 880 


Leu Val Leu His Leu Val Pro Ile Glu Val Val Asn Arg Ile Thr Leu 
                885                 890                 895     


Gln Ile Lys Lys His Ser Val Leu Thr Asn Ser Thr Leu Asp Asp Thr 
            900                 905                 910         


Arg Ala Ala Tyr Thr Asp Ile His Gln Ala Phe Ser Leu Tyr Leu Gly 
        915                 920                 925             


Val His Gly Ala Ile Leu Gly Leu Gln Ser Leu Ser Asn Glu Pro Glu 
    930                 935                 940                 


Leu Gln Val Phe Phe Glu Lys Glu Ser Asp Phe Asn Asn Leu Phe Thr 
945                 950                 955                 960 


Asp Asn Gly Glu Gly Leu Val Pro Val Lys Gly Leu Arg Asp Ile Leu 
                965                 970                 975     


Arg Phe Gly Asn Leu Glu Gln Leu Lys Lys Met Phe Ser Asp Lys Lys 
            980                 985                 990         


Val Ala Ser Asp Asp Ile Thr Asn  Leu Lys Glu Tyr Leu  Glu Ala Thr 
        995                 1000                 1005             


Gly Gly  Lys Ser Lys Ile Ala  Arg Ala Gln Glu Lys  Arg Ile Glu 
    1010                 1015                 1020             


Leu His  Lys Thr Leu Thr Glu  Leu Pro Lys Arg Leu  Thr Lys Pro 
    1025                 1030                 1035             


Arg Val  Lys Gln Thr Gly Ile  Asp Thr Tyr Glu Lys  Asn Asn Asn 
    1040                 1045                 1050             


Ile Ser  Ile Ser Gly Ser Ile  Ser Glu Tyr Arg Lys  Asp Leu Lys 
    1055                 1060                 1065             


Cys Ile  Val Ser Tyr Arg Glu  Leu Lys Asn Lys Ile  Tyr Leu Tyr 
    1070                 1075                 1080             


Asn Val  Lys Gln Ala His Gln  Leu Ile Met Ala Thr  Gln Ala Arg 
    1085                 1090                 1095             


Leu Leu  Gly Tyr Ser Gln Ile  Arg Glu Arg Asp Leu  Tyr Phe Val 
    1100                 1105                 1110             


Leu Leu  Thr Gln Leu Met Leu  Arg Gly Val Thr Leu  Glu Lys Glu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Asp Lys Asp  Lys Leu Asn Ala Leu  Asp Thr Asp 
    1130                 1135                 1140             


Thr Val  Leu Asp Glu Glu Glu  Lys Lys Lys Leu Glu  Lys Gln Ile 
    1145                 1150                 1155             


Lys Pro  Glu Arg Ser Leu Lys  Asp Leu Val Glu Lys  Gly Leu Ile 
    1160                 1165                 1170             


Phe Leu  Ala Leu Asp Gln Leu  Ser Ser Ser Asp Lys  Asp Leu Lys 
    1175                 1180                 1185             


Ala Ile  His Ser Glu Ile Glu  Asp Met Phe Val Gly  Val Ser Pro 
    1190                 1195                 1200             


Asp Ser  Asp Asn Arg Asn Leu  Arg Asn Arg Leu Ala  His Phe Lys 
    1205                 1210                 1215             


Asp Leu  Gly Asn Lys Asn Leu  Ile Asn Ile Thr Ser  Gln Ile Asn 
    1220                 1225                 1230             


Glu Val  Arg Lys Met Met Ser  Tyr Asp Arg Lys Leu  Lys Asn Ala 
    1235                 1240                 1245             


Val Ser  Lys Ser Met Ile Asp  Leu Phe Glu Arg Tyr  Asn Leu Ile 
    1250                 1255                 1260             


Leu Ser  Phe Lys Val Gln Ser  His Lys Leu Gln Leu  Lys Asn Leu 
    1265                 1270                 1275             


Lys Ser  Lys Gln Ile Thr His  Leu Asn Asn Lys Gly  Ile Thr Glu 
    1280                 1285                 1290             


Asn Leu  Leu Ser Asp Asp Tyr  Val Ser Val Ile Lys  Arg Leu Leu 
    1295                 1300                 1305             


Leu Thr  Glu Gln Asn Pro Glu  
    1310                 1315 


<210>  830
<211>  1330
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  830

Met Lys Arg Glu Lys Asn Ile Thr Ile Met Lys Ile Ser Lys Val Asn 
1               5                   10                  15      


His Arg Arg Thr Ala Val Ala Leu Asn Gly Asp Lys Ser Glu Leu Gly 
            20                  25                  30          


Gly Ile Leu Tyr Glu Ala Pro Val Gln Lys Asp Lys Asn Gly Asn Tyr 
        35                  40                  45              


Asn Asp Val Ile Ala Glu Thr Gly Lys Val Val Asn Glu Ala Leu Asp 
    50                  55                  60                  


Lys Lys Ser Arg Leu Tyr Thr Pro Phe Asn Asn Gln Lys Val Ile Ile 
65                  70                  75                  80  


Asp Lys Asn Leu Gln Arg Tyr Ala Asn Asn Leu Lys Arg Cys Tyr Ile 
                85                  90                  95      


Asn Phe Val Lys Gln Tyr Val Asn Asn Lys Ser Phe Asn Tyr Lys Ala 
            100                 105                 110         


Met Gln Phe Ile Pro Asp Ile Gln Asn Pro Lys Thr Asn Asp Ala Val 
        115                 120                 125             


Asn Tyr Arg Thr Asp Arg Asp Asn Val Tyr Asn Lys Asn Lys Tyr Tyr 
    130                 135                 140                 


Asp Lys Gln Thr Lys Ser Lys Ser Lys Lys Phe Ile Tyr Glu Lys Ile 
145                 150                 155                 160 


Val Ile Pro Gln Asn Glu Gln Asn Ile Val Ile Ser Ala Leu Val Asn 
                165                 170                 175     


Cys Ser Leu Arg Lys Ser Leu Arg Lys Asp Val Ser Tyr Lys Thr Lys 
            180                 185                 190         


Ser Gly Glu Ile Lys Thr Tyr Asn Leu Pro Glu Leu Val Lys Lys Ser 
        195                 200                 205             


Met Arg Phe Tyr Cys Leu Glu Gly Gln Arg Glu Pro Asp Glu Lys Glu 
    210                 215                 220                 


Lys Tyr Glu Met Tyr Ile Leu Phe Ser Tyr Met Lys Glu Asp Lys Arg 
225                 230                 235                 240 


Thr Lys Asn Thr Asp Leu Leu Val Lys Ser Ile Ser Asn Gln Asn Thr 
                245                 250                 255     


Lys Val Lys Val Glu Asp Ile Asp Gly Asn Lys Leu Leu Lys Leu Ser 
            260                 265                 270         


Ile Ala Asp Thr Lys Lys Lys Pro Leu Trp Glu Tyr Leu Ile Lys Tyr 
        275                 280                 285             


Ala Asp Ser Ser Arg Gln Arg Glu Leu Met Tyr Asp Ile Arg Lys Lys 
    290                 295                 300                 


Ile Ile Leu Tyr Val Ala Gly Ile Glu Glu Tyr Glu Asn Ile Lys Glu 
305                 310                 315                 320 


Asp Ser Gly Leu Ser Lys Val Ser Trp Ser Lys Tyr Asn Ile Ser Asp 
                325                 330                 335     


Asn Lys Met Phe Phe Asp Ile Asn Ser Cys Thr Asp Lys Arg Lys Gln 
            340                 345                 350         


Asn Leu Glu Ile Lys Ile Arg Glu Ala Asn Ile Glu His Tyr Arg Asn 
        355                 360                 365             


Ala Ser Ser Lys Leu Cys Asp Asp Glu Ser Ile Phe Trp Phe Gln His 
    370                 375                 380                 


Phe Glu Gly Val Ile Glu Thr Leu Phe Ser Lys Lys Ser Lys Ile Ser 
385                 390                 395                 400 


Glu Glu Arg Leu Gly Cys Ala Tyr Ile Cys Asp Tyr Leu Trp Lys Asp 
                405                 410                 415     


Phe Leu Ser Tyr Leu Ala Ala Lys Tyr Ile Asp Leu Gly Lys Gly Val 
            420                 425                 430         


Tyr His Phe Thr Met Lys Asp Lys Leu Asp Met Leu Asn Lys Asn Glu 
        435                 440                 445             


Ala Val Thr Asp Leu Arg Phe Gly Ile Val Ser Glu Lys Tyr Glu Lys 
    450                 455                 460                 


Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Glu Leu 
465                 470                 475                 480 


Asp Arg Asn Ile Ala Ala Tyr Val Thr Phe Ala Ala Asp Ile Phe Ala 
                485                 490                 495     


Lys Ser Val Ile Lys Ser Asp Tyr Arg Thr Lys Lys Asp Asn Asn Ser 
            500                 505                 510         


Asp Val Leu Gln Tyr Ser Asp Lys Glu Phe Arg Asn Ser Glu Val Ile 
        515                 520                 525             


Arg Asp Asn Ala Glu Lys Asn Ile Leu Gln Tyr Trp Gly Gly Tyr Ser 
    530                 535                 540                 


Arg Trp Cys Thr Glu Asn Ser Lys Leu Pro Glu Asn Asn Lys Val Ser 
545                 550                 555                 560 


Asp Phe Gly Lys Leu Asp Val Ser Asp Leu Cys Ile Asp Ile Lys Lys 
                565                 570                 575     


His Leu Ala Gly Ile Arg Asn Ser Ser Val His Tyr Thr Thr Lys Ile 
            580                 585                 590         


Lys Asn Glu Ser Ala Ala Asp Gly Ser Asn Val Lys Ile Leu Phe Glu 
        595                 600                 605             


Lys Asp Leu Ala Asp Ile Asn Ile Ile Tyr Ala Asp Lys Tyr Tyr Ser 
    610                 615                 620                 


Asn Asn Val Trp Met Phe Tyr Ser Leu Glu Asp Ile Asn Lys Leu Ile 
625                 630                 635                 640 


Ala Phe Leu Tyr Lys Glu Lys Arg Val Ile Arg Gln Val Gln Ile Pro 
                645                 650                 655     


Ser Phe Ser Arg Ile Leu Lys Arg Lys Ala Met Gln Asp Val Ile Asn 
            660                 665                 670         


Glu Ile Phe Lys Asp Asp Phe Asp Glu Asn Ile Val Asn Pro Glu Leu 
        675                 680                 685             


Lys Glu Lys Tyr Arg Asn Ser Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
    690                 695                 700                 


Tyr Asn Ala Phe Ile Ile Gln Pro Glu Leu Lys Glu Lys Phe Lys Asp 
705                 710                 715                 720 


Lys Ile Lys Thr Met Lys Ser Glu Leu Tyr Asn Lys Leu Lys Thr Ile 
                725                 730                 735     


Asp Lys Lys Glu Tyr Lys Ala Leu Tyr Cys Met Leu Ser Asn Glu Glu 
            740                 745                 750         


Ser Ala Leu Lys Asn Phe Ala Asp Arg Ile Tyr Ser Val Asp Gly Asp 
        755                 760                 765             


Asn Val Ser Phe Ala Asp Ile Cys Lys Ile Leu Met Thr Asp Tyr Asn 
    770                 775                 780                 


Met Gln Asn Gln Glu Lys Lys Asn Ile Glu Ser Met Glu Gln Lys Lys 
785                 790                 795                 800 


Lys Asn Lys Gly Lys Asp Glu Asn Tyr Lys His Phe Pro Leu Leu Leu 
                805                 810                 815     


His Lys Val Leu Lys Glu Leu Phe Ile Glu Tyr Leu Lys Gln Thr His 
            820                 825                 830         


Glu Leu Glu Phe Leu Arg Asn Asn Ile Cys Ile Lys Ser Asp Val Thr 
        835                 840                 845             


Met Glu Ser Phe Glu Ser Gln Ile Lys Gly Val Glu Ile Tyr Lys Asp 
    850                 855                 860                 


Leu Lys Glu Lys Ile Asp Lys Asn Asn Ser Leu Leu Asp Trp Tyr Val 
865                 870                 875                 880 


Ile Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asn 
                885                 890                 895     


Ile Lys Asn Tyr Ile Gln Phe Ala Thr Asn Ile Asp Lys Arg Ala Glu 
            900                 905                 910         


Ser Val Lys Asn Leu Thr Glu Ser Gly Met Val Lys Arg Ile Gln Tyr 
        915                 920                 925             


Tyr Asp Asp Ile Val Arg Thr Leu Glu Phe Ser Ala Gln Tyr Ile Gly 
    930                 935                 940                 


Lys Ile Ser Asn Asn Ile Asn Asp Tyr Phe Asn Ser Glu Asp Glu Tyr 
945                 950                 955                 960 


Val Ser Phe Leu Ser Lys Tyr Val Gly Phe Ile Asn Asp Lys Ser Glu 
                965                 970                 975     


Asp Val Leu Thr Glu Leu Lys Asp Phe Cys Arg Glu Lys Ile Asn Asn 
            980                 985                 990         


Gly Ser Gln Ile Ile Gly Ile Tyr  Tyr Gly Gly Asp Asn  Val Ile Ile 
        995                 1000                 1005             


Asn Arg  Asn Val Ile Tyr Ala  Gln Met Tyr Ser Asn  Ala Glu Val 
    1010                 1015                 1020             


Phe Ser  Asn Ile Tyr Lys Lys  Val Thr Lys Asn Asp  Ile Ile Asn 
    1025                 1030                 1035             


Tyr Tyr  Glu Lys Gln Asn Asp  Leu Lys Asp Val Phe  Lys Ser Gly 
    1040                 1045                 1050             


Val Cys  Gln Asn Glu Asp Glu  Gln Arg Ser Leu Cys  Glu Phe Gln 
    1055                 1060                 1065             


Gln Leu  Lys Asn Arg Ile Glu  Leu Thr Glu Leu Ser  Thr Tyr Ala 
    1070                 1075                 1080             


Asp Met  Val Asn Asp Phe Met  Ala Gln Phe Val Glu  Trp Ala Tyr 
    1085                 1090                 1095             


Leu Arg  Glu Arg Asp Leu Met  Tyr Phe Gln Leu Gly  Ile His Tyr 
    1100                 1105                 1110             


Ile Arg  Leu Phe Tyr Ser Asp  Asn Val Leu Asp Glu  Lys Tyr His 
    1115                 1120                 1125             


Lys Leu  Ser Asp Asn Val Ile  Asp Ile Glu Glu Gly  Ala Leu Leu 
    1130                 1135                 1140             


Tyr Gln  Ile Val Ala Met Tyr  Asp Tyr Glu Leu Arg  Ile Phe Glu 
    1145                 1150                 1155             


Thr Asp  Asn Ser Gly Asn Ala  Lys Arg Ile Gly Gln  Gly Gly Pro 
    1160                 1165                 1170             


Gly Lys  Ser Ile Pro Val Phe  Leu Lys Lys Tyr Cys  Ser Gly Thr 
    1175                 1180                 1185             


Asp Val  Tyr Glu Cys Gly Leu  Glu Leu Phe Glu Asp  Ile Asn Gln 
    1190                 1195                 1200             


His Glu  His Ile Ile Arg Phe  Arg Asn Asp Ile Ala  His Met Arg 
    1205                 1210                 1215             


Tyr Met  Ser Asn Gln Ala Met  Asn Ile Met Ser Ile  Val Ser Asn 
    1220                 1225                 1230             


Ile Tyr  Lys Ser Phe Phe Ala  Tyr Asp Thr Lys Leu  Lys Lys Ser 
    1235                 1240                 1245             


Ile Ser  Leu Val Phe Lys Asn  Ile Leu Met Arg Tyr  Gly Val Ile 
    1250                 1255                 1260             


Ala Asp  Leu Val Phe Ser Tyr  Asn Asn Lys Asn Gln  Ser Ile Lys 
    1265                 1270                 1275             


Asp Asp  Met Asp Ile Asn Ile  Ile Asn Ile Lys Asn  Leu Lys Ser 
    1280                 1285                 1290             


Asp Lys  Tyr Val Tyr Lys Ile  Val Asn Glu Asp Ile  Val Lys Gln 
    1295                 1300                 1305             


Val Glu  Ile Glu Ile Arg Asn  Gln Val Phe Leu Glu  Gln Leu His 
    1310                 1315                 1320             


Asn Leu  Leu Tyr Phe Ser Arg  
    1325                 1330 


<210>  831
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  831

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Gly Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asp 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  832
<211>  1330
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  832

Met Lys Arg Glu Lys Asn Ile Thr Ile Met Lys Ile Ser Lys Val Asn 
1               5                   10                  15      


His Arg Arg Thr Ala Val Ala Leu Asn Gly Asp Lys Ser Glu Leu Gly 
            20                  25                  30          


Gly Ile Leu Tyr Glu Ala Pro Val Gln Lys Asp Lys Asn Gly Asn Tyr 
        35                  40                  45              


Asn Asp Val Ile Ala Glu Thr Gly Lys Val Val Asn Glu Ala Leu Asp 
    50                  55                  60                  


Lys Lys Ser Arg Leu Tyr Thr Pro Phe Asn Asn Gln Lys Val Ile Ile 
65                  70                  75                  80  


Asp Lys Asn Leu Gln Arg Tyr Ala Asn Asn Leu Lys Arg Cys Tyr Ile 
                85                  90                  95      


Asn Phe Val Lys Gln Tyr Val Asn Asn Lys Ser Phe Asn Tyr Lys Ala 
            100                 105                 110         


Met Gln Phe Ile Pro Asp Ile Gln Asn Pro Lys Thr Asn Asp Ala Val 
        115                 120                 125             


Asn Tyr Arg Thr Asp Arg Asp Asn Val Tyr Asn Lys Asn Lys Tyr Tyr 
    130                 135                 140                 


Asp Lys Gln Thr Lys Ser Lys Ser Lys Lys Phe Ile Tyr Glu Lys Ile 
145                 150                 155                 160 


Val Ile Pro Gln Asn Glu Gln Asn Ile Val Ile Ser Ala Leu Val Asn 
                165                 170                 175     


Cys Ser Leu Arg Lys Ser Leu Arg Lys Asp Val Ser Tyr Lys Thr Lys 
            180                 185                 190         


Ser Gly Glu Ile Lys Thr Tyr Asn Leu Pro Glu Leu Val Lys Lys Ser 
        195                 200                 205             


Met Arg Phe Tyr Cys Leu Glu Gly Gln Arg Glu Pro Asp Glu Lys Glu 
    210                 215                 220                 


Lys Tyr Glu Met Tyr Ile Leu Phe Ser Tyr Met Lys Glu Asp Lys Arg 
225                 230                 235                 240 


Thr Lys Asn Thr Asp Leu Leu Val Lys Ser Ile Ser Asn Gln Asn Thr 
                245                 250                 255     


Lys Val Lys Val Glu Asp Ile Asp Gly Asn Lys Leu Leu Lys Leu Ser 
            260                 265                 270         


Ile Ala Asp Thr Lys Lys Lys Pro Leu Trp Glu Tyr Leu Ile Lys Tyr 
        275                 280                 285             


Ala Asp Ser Ser Arg Gln Arg Glu Leu Met Tyr Asp Ile Arg Lys Lys 
    290                 295                 300                 


Ile Ile Leu Tyr Val Ala Gly Ile Glu Glu Tyr Glu Asn Ile Lys Glu 
305                 310                 315                 320 


Asp Ser Gly Leu Ser Lys Val Ser Trp Ser Lys Tyr Asn Ile Ser Asp 
                325                 330                 335     


Asn Lys Met Phe Leu Asp Ile Asn Ser Cys Thr Asp Lys Arg Lys Gln 
            340                 345                 350         


Asn Leu Glu Ile Lys Ile Arg Glu Ala Asn Ile Glu His Tyr Arg Asn 
        355                 360                 365             


Ala Ser Ser Lys Leu Cys Asp Asp Glu Ser Ile Phe Trp Phe Gln His 
    370                 375                 380                 


Phe Glu Gly Val Ile Glu Thr Leu Phe Ser Lys Lys Ser Lys Ile Ser 
385                 390                 395                 400 


Glu Glu Arg Leu Gly Cys Ala Tyr Ile Cys Asp Tyr Leu Trp Lys Asp 
                405                 410                 415     


Phe Leu Ser Tyr Leu Ala Ala Lys Tyr Ile Asp Leu Gly Lys Gly Val 
            420                 425                 430         


Tyr His Phe Thr Met Lys Asp Lys Leu Asp Met Leu Asn Lys Asn Glu 
        435                 440                 445             


Ala Val Thr Asp Leu Arg Phe Gly Ile Val Ser Glu Lys Tyr Glu Lys 
    450                 455                 460                 


Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Glu Leu 
465                 470                 475                 480 


Asp Arg Asn Ile Ala Ala Tyr Val Thr Phe Ala Ala Asp Ile Phe Ala 
                485                 490                 495     


Lys Ser Val Ile Lys Ser Asp Tyr Arg Thr Lys Lys Asp Asn Asn Ser 
            500                 505                 510         


Asp Val Leu Gln Tyr Ser Asp Lys Glu Phe Arg Asn Ser Glu Val Ile 
        515                 520                 525             


Arg Asp Asn Ala Glu Lys Asn Ile Leu Gln Tyr Trp Gly Gly Tyr Ser 
    530                 535                 540                 


Arg Trp Gly Thr Glu Asn Ser Lys Leu Pro Glu Asn Asn Lys Val Ser 
545                 550                 555                 560 


Asp Phe Gly Lys Leu Asp Val Ser Asp Leu Cys Ile Asp Ile Lys Lys 
                565                 570                 575     


His Leu Ala Gly Ile Arg Asn Ser Ser Val His Tyr Thr Thr Lys Ile 
            580                 585                 590         


Lys Asn Glu Ser Ala Ala Asp Gly Ser Asn Val Lys Ile Leu Phe Glu 
        595                 600                 605             


Lys Asp Leu Ala Asp Ile Asn Ile Ile Tyr Ala Asp Lys Tyr Tyr Ser 
    610                 615                 620                 


Asn Asn Val Trp Met Phe Tyr Ser Leu Glu Asp Ile Asn Lys Leu Ile 
625                 630                 635                 640 


Ala Phe Leu Tyr Lys Glu Lys Arg Val Ile Arg Gln Val Gln Ile Pro 
                645                 650                 655     


Ser Phe Ser Arg Ile Leu Lys Arg Lys Ala Met Gln Asp Val Ile Asn 
            660                 665                 670         


Glu Ile Phe Lys Asp Asp Phe Asp Glu Asn Ile Val Asn Pro Glu Leu 
        675                 680                 685             


Lys Glu Lys Tyr Arg Asn Ser Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
    690                 695                 700                 


Tyr Asn Ala Phe Ile Ile Gln Pro Glu Leu Lys Glu Lys Phe Lys Asp 
705                 710                 715                 720 


Lys Ile Lys Thr Met Lys Ser Glu Leu Tyr Asn Lys Leu Lys Thr Ile 
                725                 730                 735     


Asp Lys Lys Glu Tyr Lys Ala Leu Tyr Cys Met Leu Ser Asn Glu Glu 
            740                 745                 750         


Ser Ala Leu Lys Asn Phe Ala Asp Arg Ile Tyr Ser Val Asp Gly Asp 
        755                 760                 765             


Asn Val Ser Phe Ala Asp Ile Cys Lys Ile Leu Met Thr Asp Tyr Asn 
    770                 775                 780                 


Met Gln Asn Gln Glu Lys Lys Asn Ile Glu Ser Met Glu Gln Lys Lys 
785                 790                 795                 800 


Lys Asn Lys Gly Lys Asp Glu Asn Tyr Lys His Phe Pro Leu Leu Leu 
                805                 810                 815     


His Lys Val Leu Lys Glu Leu Phe Ile Glu Tyr Leu Lys Gln Thr His 
            820                 825                 830         


Glu Leu Glu Phe Leu Arg Asn Asn Ile Cys Ile Lys Ser Asp Val Thr 
        835                 840                 845             


Met Glu Ser Phe Glu Ser Gln Ile Lys Gly Val Glu Ile Tyr Lys Asp 
    850                 855                 860                 


Leu Lys Glu Lys Ile Asp Lys Asn Asn Ser Leu Leu Asp Trp Tyr Val 
865                 870                 875                 880 


Ile Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asn 
                885                 890                 895     


Ile Lys Asn Tyr Ile Gln Phe Ala Thr Asn Ile Asp Lys Arg Ala Glu 
            900                 905                 910         


Ser Val Lys Asn Leu Thr Glu Ser Gly Met Val Lys Arg Ile Gln Tyr 
        915                 920                 925             


Tyr Asp Asp Ile Val Arg Thr Leu Glu Phe Ser Ala Gln Tyr Ile Gly 
    930                 935                 940                 


Lys Ile Ser Asn Asn Ile Asn Asp Tyr Phe Asn Ser Glu Asp Glu Tyr 
945                 950                 955                 960 


Val Ser Phe Leu Ser Lys Tyr Val Gly Phe Ile Asn Asp Lys Ser Glu 
                965                 970                 975     


Asp Val Leu Thr Glu Leu Lys Asp Phe Cys Arg Glu Lys Ile Asn Asn 
            980                 985                 990         


Gly Ser Gln Ile Ile Gly Ile Tyr  Tyr Gly Gly Asp Asn  Val Ile Ile 
        995                 1000                 1005             


Asn Arg  Asn Val Ile Tyr Ala  Gln Met Tyr Ser Asn  Ala Glu Val 
    1010                 1015                 1020             


Phe Ser  Asn Ile Tyr Lys Lys  Val Thr Lys Asn Asp  Ile Ile Asn 
    1025                 1030                 1035             


Tyr Tyr  Glu Lys Gln Asn Asp  Leu Lys Asp Val Phe  Lys Ser Gly 
    1040                 1045                 1050             


Val Cys  Gln Asn Glu Gly Glu  Gln Arg Ser Leu Cys  Glu Phe Gln 
    1055                 1060                 1065             


Gln Leu  Lys Asn Arg Ile Glu  Leu Thr Glu Leu Ser  Thr Tyr Ala 
    1070                 1075                 1080             


Asp Met  Val Asn Asp Phe Met  Ala Gln Phe Val Glu  Trp Ala Tyr 
    1085                 1090                 1095             


Leu Arg  Glu Arg Asp Leu Met  Tyr Phe Gln Leu Gly  Ile His Tyr 
    1100                 1105                 1110             


Ile Arg  Leu Phe Tyr Ser Asp  Asn Val Leu Asp Glu  Lys Tyr His 
    1115                 1120                 1125             


Lys Leu  Ser Asp Asn Val Ile  Asp Ile Glu Glu Gly  Ala Leu Leu 
    1130                 1135                 1140             


Tyr Gln  Ile Val Ala Met Tyr  Asp Tyr Glu Leu Arg  Ile Phe Glu 
    1145                 1150                 1155             


Thr Asp  Asn Ser Gly Asn Ala  Lys Arg Ile Gly Gln  Gly Gly Pro 
    1160                 1165                 1170             


Gly Lys  Ser Ile Pro Val Phe  Leu Lys Lys Tyr Cys  Asn Gly Thr 
    1175                 1180                 1185             


Asp Val  Tyr Glu Cys Gly Leu  Glu Leu Phe Glu Asp  Ile Asn Gln 
    1190                 1195                 1200             


His Glu  His Ile Ile Arg Phe  Arg Asn Asp Ile Ala  His Met Arg 
    1205                 1210                 1215             


Tyr Met  Ser Asn Gln Ala Met  Asn Ile Met Ser Ile  Val Ser Asn 
    1220                 1225                 1230             


Ile Tyr  Lys Ser Phe Phe Ala  Tyr Asp Thr Lys Leu  Lys Lys Ser 
    1235                 1240                 1245             


Ile Ser  Leu Val Phe Lys Asn  Ile Leu Met Arg Tyr  Gly Val Ile 
    1250                 1255                 1260             


Ala Asp  Leu Val Phe Ser Tyr  Asn Asn Lys Asn Gln  Ser Ile Lys 
    1265                 1270                 1275             


Asp Asp  Met Asp Ile Asn Ile  Ile Asn Ile Lys Asn  Leu Lys Ser 
    1280                 1285                 1290             


Asp Lys  Tyr Val Tyr Lys Ile  Val Asn Glu Asp Ile  Val Lys Gln 
    1295                 1300                 1305             


Val Glu  Ile Glu Ile Arg Asn  Gln Val Phe Leu Glu  Gln Leu His 
    1310                 1315                 1320             


Asn Leu  Leu Tyr Phe Ser Arg  
    1325                 1330 


<210>  833
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  833

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Asp Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Cys Gln Arg Ile Ile Asn Asp Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His 
            180                 185                 190         


Glu Arg Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Arg Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Ile His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Ile  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Arg Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  834
<211>  1287
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  834

Met Arg Ile Gly Lys Val Gln Gly Arg Thr Phe Thr Gly Phe Asp Asn 
1               5                   10                  15      


Ala Arg Gly Lys Thr Leu Arg Arg Arg Leu Leu Thr Arg Pro Asp Asn 
            20                  25                  30          


Glu Ala Arg Ser Leu Ser Glu His Leu Ala His Asp Pro Lys Ala Leu 
        35                  40                  45              


Ile Gly Gln Ala Ile Ser Arg Ile Asp Thr Ile Tyr Gln Lys Pro Lys 
    50                  55                  60                  


Thr Gly Lys Pro Thr Pro Glu Gln Phe Gly His Arg Asp Thr Leu Gly 
65                  70                  75                  80  


Trp Ala Tyr Trp Lys Leu Leu Val Ala Ser Tyr Pro Glu Val Glu Gly 
                85                  90                  95      


His Arg Asp Leu Phe Val Arg Arg Leu His Pro Tyr Gly Asp Thr Pro 
            100                 105                 110         


Pro Lys Ser His Gly Gln Lys Glu Gly Glu His Gln Lys Gly Gly Lys 
        115                 120                 125             


Pro Gln Leu Glu Gly Arg Trp His Gly Val Met Ala Gln His Gly Lys 
    130                 135                 140                 


Asn Pro Asp Gln Ile Ala Ala Arg Leu Phe Asp His Leu His Asn Ser 
145                 150                 155                 160 


Glu Leu Arg Phe Gly Gly Thr Ala Ser Gly Glu Pro Arg Thr Arg Pro 
                165                 170                 175     


Gly Lys Glu Ala Thr Pro Thr Gly Leu Ile Gly Ala Arg Ala Lys Thr 
            180                 185                 190         


Ile Glu His Ser Val Leu Pro Arg Asp Ala Lys Arg Phe Val Ala Glu 
        195                 200                 205             


Trp Arg Gly Glu Asp Gln Glu Arg Tyr Ala Gly Ala Arg Asp Ile Ala 
    210                 215                 220                 


Ala Ala Ile Ser Ala Gly Leu Asn Asp Lys Asp Gln Lys Ser Gly Ser 
225                 230                 235                 240 


Gly Arg Lys Ser Ala Val Ile Gly Lys Leu Leu Ser Asp His Leu Glu 
                245                 250                 255     


Thr Leu Thr Gly Asn Arg Lys Cys Arg Phe Asp Pro Lys Ser Thr Ala 
            260                 265                 270         


Glu Thr Leu Glu Leu Arg Asp Gly Glu Ser Val Asp Asp Arg Arg Arg 
        275                 280                 285             


Ile Leu Glu Leu His Ala Glu Val Lys Ala Thr Tyr Lys Arg Met Ala 
    290                 295                 300                 


Ala Trp Lys Pro Ala Lys Leu Pro Arg Asn Ser Asp Glu Leu Phe Arg 
305                 310                 315                 320 


Leu Val Arg Gln Gln Ala Asp Asn Arg Ile Leu Asn His Leu Val Arg 
                325                 330                 335     


Val Gly Arg Ile Ser Val Tyr Ser Glu Gln Ser Asp Ala Leu Ser Glu 
            340                 345                 350         


Ser Gln Phe Trp Thr Ser Gly Gly Gln Thr Gln Ile Lys Glu Ser Glu 
        355                 360                 365             


Val Phe Ala Arg Leu Trp Ile Gly Ala Ile Ser Arg Ala Ser Tyr Ser 
    370                 375                 380                 


Met Lys Ala Trp Leu Glu Pro Glu Gly Thr Val Phe Asn Pro Ser Ile 
385                 390                 395                 400 


Asn Asp Phe Asp Val Thr Ser Ser His Asn Thr Asn Arg Ile Leu Glu 
                405                 410                 415     


Asp Ser Gly Arg Leu Ser Asn Ala Met Ala Arg Arg Ala Ile Tyr Phe 
            420                 425                 430         


Gly Glu Thr Pro Glu Phe Asp Ala Leu Gly Glu Glu Asp Gln Arg Val 
        435                 440                 445             


Leu Val Lys Lys Cys Leu Asp Ala Leu Ser Ala Cys Arg Asn Arg Thr 
    450                 455                 460                 


Phe His His Gly Gln Arg Ala Lys Phe Leu Lys Glu Val Arg Lys Gly 
465                 470                 475                 480 


Leu Lys Glu Lys Glu Ala Asp Ser Ala Gly Pro Ala Ala Trp Glu Gly 
                485                 490                 495     


Ile Arg Glu Val Ile Gln Ala Asp Ala Arg Asn Leu Gly Ala Arg Leu 
            500                 505                 510         


Leu Gln Asp Leu Thr Gly Ala Lys Val His Ser Phe Ala Thr Asp Pro 
        515                 520                 525             


Glu Phe Arg His Leu Tyr Glu Ser Val Ala Ala Thr Leu Thr Ala Gly 
    530                 535                 540                 


Gly Glu Leu Glu Ala Ala Leu Pro Arg Leu Lys Asn Val Leu Lys Arg 
545                 550                 555                 560 


Ala Glu Gly Val Arg Cys Tyr Leu Asp Thr Pro Ser Gln Arg Arg Glu 
                565                 570                 575     


Gly Asp Glu Ser Leu Ile Ala Arg Leu Pro Val Ala Pro Val Pro Arg 
            580                 585                 590         


Glu Leu Asp Asp Ala Ala Thr Lys Ala Arg His Ser Ala Leu Leu Arg 
        595                 600                 605             


Leu Tyr Asp Gly Pro Phe Arg Pro Trp Ala Thr Glu Leu Arg Gly Glu 
    610                 615                 620                 


Arg Leu Ser Asp Tyr Ala Ala Arg Ala Lys Arg Leu Ala Thr Arg Leu 
625                 630                 635                 640 


Ala Lys Ser Thr Asn Thr Ala Ser Pro Tyr Pro Asp Ser Val Glu Gly 
                645                 650                 655     


Arg Ser Val Arg Leu Arg Asp Pro Ile Thr Ala Asp Thr Ala Pro Glu 
            660                 665                 670         


Thr Leu Lys Thr Tyr Leu Ser Ala Leu Thr Ala Glu Thr Ala Thr Glu 
        675                 680                 685             


Phe Arg Val Gln Lys Gly Tyr Glu Ser Asp Gly Glu Lys Ala Lys Glu 
    690                 695                 700                 


Gln Ala Glu Phe Ile Glu Asp Phe Arg Arg Asp Met Ile Ala Leu Ala 
705                 710                 715                 720 


Phe Gln Asp Phe Ile Arg Asp His Gly Phe Ala Trp Leu Leu Asp Ile 
                725                 730                 735     


Ala Ser Lys Ala Glu Pro Ser Asn Asp Ala Pro Asn Leu Pro Asp Pro 
            740                 745                 750         


Val Asp Thr Gly Lys Asp Thr Val Phe Glu Asp Trp Gln Ala Leu Leu 
        755                 760                 765             


Tyr Leu Phe Leu His Phe Val Pro Ala Asp Asp Val Ser Gln Leu Leu 
    770                 775                 780                 


His Gln Leu Arg Lys Trp Asp Ala Leu Gln Asp Lys Tyr Glu Leu Ala 
785                 790                 795                 800 


Glu Pro Gly Glu Thr Leu Gly Gln Thr Lys Ala Asp Thr Arg Lys Ile 
                805                 810                 815     


Val Gly Gln Phe Arg Asp Cys Leu Thr Leu Phe Leu Lys Thr Gly Asp 
            820                 825                 830         


Ala Arg Phe Asp Gly Glu Gly Val Glu Leu Pro Leu Ser Asp Phe Gln 
        835                 840                 845             


Glu Leu Phe Glu Ser Pro Ala Thr Phe Lys Glu Leu Phe Leu Ala Glu 
    850                 855                 860                 


Pro Ala Glu Asn Asp Ala Ser Glu Thr Asp Asp Gln Asp Ala Pro Gly 
865                 870                 875                 880 


Glu Lys His Arg Val Thr Arg Thr Arg Arg Gly Leu Arg Gln Ile Leu 
                885                 890                 895     


Arg Tyr Asn His Met Pro Val Leu Arg Asp Leu Phe Leu Ala His Lys 
            900                 905                 910         


Val Thr Asp Ala Glu Val Asp Gly Leu Gln Ala Leu Glu Val Asp Asp 
        915                 920                 925             


Pro Gln Thr Gly Glu Ser Gln Ile Gly Ala Ala Gln Arg Ile Arg Thr 
    930                 935                 940                 


Glu Ile His His His Thr Ser Asn Asp Lys Gln Ile Ser Glu Ala Lys 
945                 950                 955                 960 


Val Glu Glu Tyr Arg Arg Ala Leu Ser Thr Ile Glu Arg His Arg Phe 
                965                 970                 975     


Leu Val Gly Arg Val Tyr Leu Gly Asp His Ile Arg Val His Lys Leu 
            980                 985                 990         


Met Met Asp Val Met Gly Arg Leu  Val Asp Phe Ala Gly  Ala Trp Glu 
        995                 1000                 1005             


Arg Glu  Ala Ala Asp Gly Asp  Arg Lys Gly Phe Ile  Ser Arg Ala 
    1010                 1015                 1020             


Ile Ala  Leu Pro Glu Val Ala  Glu Gly Tyr Ala Ala  Asp Arg Leu 
    1025                 1030                 1035             


Lys Thr  Val Ala Arg Arg Val  Leu Asp Asp Gly Glu  Ala Arg Arg 
    1040                 1045                 1050             


Ile Arg  Asn Asp Leu Gly His  Phe Asn Asp Leu Ala  Pro Thr Ser 
    1055                 1060                 1065             


Gly Pro  Ala Asn Leu Thr Phe  Val Val Asn Arg Ala  Arg Arg Met 
    1070                 1075                 1080             


Met Arg  His Asp Arg Lys Arg  Lys Asn Ala Val Thr  Lys Ser Val 
    1085                 1090                 1095             


Ile Glu  Ile Leu Asn Arg Gln  Gly Leu Gly Ile Glu  Trp Thr Met 
    1100                 1105                 1110             


Arg Asn  His Glu Leu Cys Glu  Ala Lys Leu Trp Gln  Asn Pro Val 
    1115                 1120                 1125             


Lys His  Leu Gly Phe Ala Thr  Leu Glu Gly Arg Gly  Lys Lys Trp 
    1130                 1135                 1140             


Arg Arg  Pro Phe Glu Ala Arg  Tyr Gly Asp Ala Tyr  Met Ala Met 
    1145                 1150                 1155             


Val Ala  Gln Leu Phe Asp Gly  Thr Val Thr Ser Pro  Pro Ala Lys 
    1160                 1165                 1170             


Gly Pro  Pro Gln Ser Gly Lys  Ser Gly Gly Lys Pro  Gly Lys Gly 
    1175                 1180                 1185             


Ala Glu  Gly Gly Ala Lys Glu  Lys Ser Arg Ser Pro  Thr Arg Met 
    1190                 1195                 1200             


Glu Glu  Gly Gly Val Tyr Glu  Gly Arg Val Ala Lys  Ala Lys Ser 
    1205                 1210                 1215             


Asp Lys  Gly Phe Gly Phe Leu  Leu Val Glu Gly Ala  Gln Glu Glu 
    1220                 1225                 1230             


Ile Phe  Leu His Ile Tyr Gly  Ile Ser Gly Asn Arg  Pro Ala Arg 
    1235                 1240                 1245             


Ile Glu  Asn Gly Gln Arg Tyr  Arg Phe Thr Leu Gly  Ile Asp Arg 
    1250                 1255                 1260             


Asp Arg  Glu Arg Arg Lys Glu  Arg Ala Trp Val Ala  Arg Glu Ala 
    1265                 1270                 1275             


Val Arg  Ile Asp Glu Asn Arg  Ser Lys 
    1280                 1285         


<210>  835
<211>  1373
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  835

Met Ala Lys His Leu Arg Pro Ile Gly Glu Ser Tyr Thr Asp Phe Leu 
1               5                   10                  15      


Asp Glu Thr Glu Phe Val Arg Leu Gly Arg Gly Leu His Arg Gly His 
            20                  25                  30          


His Gly Val Gln Ile Pro Pro Thr Glu Leu Pro Ser Tyr Leu Ala Glu 
        35                  40                  45              


Tyr Arg Lys Ala Leu Met Arg Gln Val Val Ala Val Leu Asp Lys Val 
    50                  55                  60                  


Val Gly Lys Arg Arg Arg Leu Ser Gly Met His Pro Glu Ala Tyr Arg 
65                  70                  75                  80  


Asp Arg Val His Leu Ala Glu Ala Leu Trp Val Arg Leu Val Ala Arg 
                85                  90                  95      


Val Lys Glu Ile Gly Thr Pro Pro Asp Pro Ser Glu Leu Leu Asp Leu 
            100                 105                 110         


Arg Arg Met Trp Asn Ala Lys Ala His Pro Tyr Ala Glu Tyr Asp Val 
        115                 120                 125             


Val Pro Arg Ala Pro Leu Asn Asp Gly Asn Gly Gln Lys Ile Leu Glu 
    130                 135                 140                 


Cys Arg Glu Val Asp Asp Pro Lys Ile Glu Arg Ser Asp Phe Glu Gly 
145                 150                 155                 160 


Arg Trp His Gly Arg Phe Trp Gln Ser Glu Pro Gly Pro Val Asp Tyr 
                165                 170                 175     


Asn Ala Ile Ala Asp Arg Ile Phe Ala His Leu Phe Asp Gln Glu Ala 
            180                 185                 190         


Val Ile Gly Gly Gly Pro Arg Arg Glu Gly Asn Val Thr Val Pro Asp 
        195                 200                 205             


Glu Asp Ile Asn Gly Gln Pro Gly Pro Ala Thr Gly Lys Gly Leu Ile 
    210                 215                 220                 


Ile Ala Arg Gly Gln Ser Ile Val Lys Ser Ala Ser Asp Pro Arg Arg 
225                 230                 235                 240 


Ser Ser Lys Lys Val Gln Arg Thr Trp Asp Lys Ala Val Glu Arg Arg 
                245                 250                 255     


Tyr Phe Gly Asp Asp Gly Lys Gly Gly Ser Asp Ile Ala Lys Ala Ile 
            260                 265                 270         


Tyr Glu Glu Leu Gly Asp Pro Ala Thr Leu Ala Asp Pro Ile Tyr Ala 
        275                 280                 285             


Ser Trp Phe Gly Ser Arg Leu Tyr Asp His Phe Gly Ser Phe Lys Asn 
    290                 295                 300                 


Ser Leu Pro Leu Glu Leu Lys Asp Pro Phe Lys Glu Gln Ile Trp Ala 
305                 310                 315                 320 


Leu His Asn Ser Val Arg Gln Phe Tyr Gln Arg Met Ala Lys Ser Asp 
                325                 330                 335     


Arg Phe Arg Leu Ala Leu Gln Asn Ala Arg Ser Glu Val Pro Asp Arg 
            340                 345                 350         


Ser Glu Leu Leu Ala Leu Leu Pro Lys Asp His Asp His Leu Leu Leu 
        355                 360                 365             


Val Leu Gly Gly Lys Lys Lys Asn Ala Glu Met Ser Glu Leu Ile Arg 
    370                 375                 380                 


Leu Gly Lys Leu Phe Val His Ala Ser Asp Val Leu His Asp Phe Asp 
385                 390                 395                 400 


Ala Asn Asp Ala Ala Ala Leu Asp Ala Phe Lys Arg Arg Met Ser Phe 
                405                 410                 415     


Leu Ala Thr Ser Ile Gly Gln Ser Glu Ile Lys Gln Thr Glu Thr Phe 
            420                 425                 430         


Ala Arg Thr Trp Arg Gly Ala Val Gly Leu Thr Leu Arg Thr Val Lys 
        435                 440                 445             


Gly Leu Ala Asp Pro Arg Gly Ile Ile Gly Thr Pro Asp Asn Arg Asp 
    450                 455                 460                 


Leu Gly Thr Ala Gly Pro Met Lys Asp Ala Phe Asn Lys Phe Asp Gln 
465                 470                 475                 480 


Pro His Phe Gln Gln His Met Thr Ile Ile Phe Gly Asn Lys Glu Leu 
                485                 490                 495     


Gln Ala Glu Gly Asn Pro Thr Arg Ser Ser Val Phe Thr Ala Asn Gly 
            500                 505                 510         


Asp Lys Asp His Gln Ala Glu Leu Leu Trp Gly Phe Leu Cys Val Val 
        515                 520                 525             


Arg Ser Val Arg Asn Arg Thr Asn His Tyr Asn Val Arg Arg Ala Leu 
    530                 535                 540                 


Leu Arg Leu Leu Asp Glu Gly Ile Val Ser Pro Met Pro Ser Asp Pro 
545                 550                 555                 560 


Lys Lys Glu Arg Val Glu Asn Arg Asn Leu Cys Thr Val Ser Pro Thr 
                565                 570                 575     


Ala Leu Glu Ala Phe Arg Arg Leu Leu Asn Phe Asp Leu Ala Ile Gln 
            580                 585                 590         


Lys Glu Ala Val Arg Thr Ala Leu Glu Gln Ala Lys Ala Ser Glu Phe 
        595                 600                 605             


Val Glu Glu Gly Lys Leu Arg Gly Leu Val Ser Glu Leu Ala Gly Thr 
    610                 615                 620                 


Glu Asp Met Pro Ala Leu His Ile Pro Arg Phe Ser Ala Val Met Asp 
625                 630                 635                 640 


Lys Val Arg Arg Leu Ala Asp Asn Arg Asp Val Gly Leu Asp Pro Ile 
                645                 650                 655     


Leu Ser Thr Leu Gln Arg Ser Leu Pro Pro Thr Asp Lys Gln Ala Glu 
            660                 665                 670         


Ser Asp Ala Ala Arg Cys Arg Tyr Arg Leu Leu Leu Glu Leu Tyr Lys 
        675                 680                 685             


Ser Gly Phe Arg Ser Trp Phe Ser Gly Ile Gln Ser Asn Glu Glu Asn 
    690                 695                 700                 


Asn Arg Glu Ile Cys His Trp Ala Val Lys Gln Val Gly Arg Ala Lys 
705                 710                 715                 720 


Asp Ala Arg Lys Ser Glu Tyr Asp Lys Lys Thr Lys Arg His Tyr Arg 
                725                 730                 735     


Ser Pro Asn Ser Leu Ile Asp Asp Leu Gly Leu Asp Lys Phe Asp Asp 
            740                 745                 750         


Leu Thr Asp Leu Leu Glu Ala Leu Ala Ser Gln Ser Thr Arg Glu His 
        755                 760                 765             


Asp Gln Asn Leu Lys Tyr Val Pro Asp Ala Arg Val Gln Ser Gln Met 
    770                 775                 780                 


Ser Asn Arg Ile Glu Glu Phe Arg Gln Glu Leu Phe Ala His Ile Phe 
785                 790                 795                 800 


Thr Lys Tyr Leu Asp Thr His Asp Phe Gly Trp Ile Gly Ala Ile Glu 
                805                 810                 815     


Val Arg Arg Glu Ala Cys Asp Leu Ala Asp Val Val Ser Ala Phe Glu 
            820                 825                 830         


Val Arg Asp Gln Lys Phe Asp Ala Asp Trp His Ser Gln Phe Tyr Ala 
        835                 840                 845             


Trp Leu Tyr Met Val Pro Pro Ile Glu Ala Ser Arg Leu Arg His Gln 
    850                 855                 860                 


Met Arg Lys Ser Ala Val Met Asp Asp Lys Trp Ser Thr Thr Leu Glu 
865                 870                 875                 880 


Leu Thr Ser Gly Asp Arg Lys Thr Arg Asp Asp His Ala Gln Asp Val 
                885                 890                 895     


Leu Ala Asp Met Asp Arg Leu Phe Ser Leu Tyr Thr Lys Val Gln Ala 
            900                 905                 910         


Ala Gly Phe Asn Gly Gln Glu His Glu Ser Ala Leu Gly Ser Lys Ser 
        915                 920                 925             


Leu Phe Tyr Glu Asp Gly Asn Gln Phe Asp Glu Val Tyr Ser Pro Asp 
    930                 935                 940                 


Thr Glu Thr His Asn Lys Thr Phe Pro Gly Thr Arg Arg Gly Leu Arg 
945                 950                 955                 960 


Gln Leu Val Arg Tyr Ala His Leu Pro Ala Leu Glu Gly Val Phe Lys 
                965                 970                 975     


Lys His Arg Ile Thr Lys Ala Glu Val Glu Thr Phe Val Ala Leu Tyr 
            980                 985                 990         


Asp Glu Asn Arg Arg Asp Pro Gly  Ser Val Ala His Met  Leu Arg Arg 
        995                 1000                 1005             


Glu Lys  Leu Arg Thr Glu Ile  Leu Arg Ser Ile His  Asp Gly Pro 
    1010                 1015                 1020             


Lys Pro  Lys Asp Lys Asp Phe  Trp Pro Lys Leu Glu  Ala Lys Cys 
    1025                 1030                 1035             


Leu Glu  Tyr Arg Thr Val Ala  Thr Glu Thr Ala Ile  Tyr Asn Phe 
    1040                 1045                 1050             


Gln Ala  Asn Ala Ala Arg Leu  Asn Asp His Ala Arg  Leu His Gln 
    1055                 1060                 1065             


Ile Val  Met Arg Val Val Ala  Arg Leu Thr Asp Tyr  Ala Leu Ile 
    1070                 1075                 1080             


Trp Glu  Arg Asp Arg Leu Phe  Ala Phe Val Gly Met  Leu Tyr Arg 
    1085                 1090                 1095             


Gln Thr  Gly Gly Thr Gly Ile  Asn Pro Ala Met Arg  His Ala Glu 
    1100                 1105                 1110             


Lys Thr  Asn Ala Pro Pro Arg  Ile Gly Ile Leu Val  Ser Asp Ser 
    1115                 1120                 1125             


Ala Leu  Ala Lys Lys Leu Asn  Ser Asn Ser Ala Glu  Val Phe Ile 
    1130                 1135                 1140             


Pro Tyr  Leu Asp Thr Glu Thr  Gly Phe Asp Ala Pro  Arg Phe Asp 
    1145                 1150                 1155             


Asp Leu  Cys Thr Leu Leu Ser  His Glu His Ala Lys  Glu Phe Arg 
    1160                 1165                 1170             


Phe His  Phe Leu Glu Val Gly  Glu Glu Asn Ser Lys  Asp Glu Ala 
    1175                 1180                 1185             


Arg Arg  Leu Asn Glu Glu Thr  Met Gly His Arg Lys  Arg Pro Ala 
    1190                 1195                 1200             


Phe Lys  Arg Gly Thr Arg Arg  Gln Gly Ile Arg Asn  Asp Leu Ala 
    1205                 1210                 1215             


His His  Asn Val Leu Asp Leu  Ala Gly Gly Ala Gly  Pro Asn Leu 
    1220                 1225                 1230             


Thr Tyr  Val Val Asn Ala Val  Arg Ser Leu Leu Ser  Tyr Asp Arg 
    1235                 1240                 1245             


Lys Leu  Lys Asn Ala Val Pro  Lys Ser Ile Lys Arg  Ile Leu Gly 
    1250                 1255                 1260             


Glu Glu  Gly Leu Ile Ile Glu  Trp Gln Met Asn Tyr  Asp Arg Leu 
    1265                 1270                 1275             


Lys Lys  Pro Thr Val Tyr Pro  Asn Val Glu Thr His  Leu Thr Met 
    1280                 1285                 1290             


Val Pro  Pro Arg His Met Thr  Ala Pro Val Ser Phe  Thr Leu Pro 
    1295                 1300                 1305             


Arg Ala  Ser Val Arg Leu Ala  Ser Met Val Lys Ala  Val Phe Asp 
    1310                 1315                 1320             


Phe Gly  Ser Ser Gly Tyr Gly  Glu Glu Arg Met Ile  Gly Gly Arg 
    1325                 1330                 1335             


Thr Ala  Lys Gln Ala Val Tyr  Pro Asp Asp Phe Thr  Arg Arg Phe 
    1340                 1345                 1350             


Pro Gln  Thr Pro Met Gly Leu  Lys Gln Ala Thr Arg  Leu Val Phe 
    1355                 1360                 1365             


Ala Ser  Glu Asn Ser 
    1370             


<210>  836
<211>  1330
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  836

Met Lys Arg Glu Lys Asn Ile Thr Ile Met Lys Ile Ser Lys Val Asn 
1               5                   10                  15      


His Arg Arg Thr Ala Val Ala Leu Asn Gly Asp Lys Ser Glu Leu Gly 
            20                  25                  30          


Gly Ile Leu Tyr Glu Ala Pro Val Gln Lys Asp Lys Asn Gly Asn Tyr 
        35                  40                  45              


Asn Asp Val Ile Ala Glu Thr Gly Lys Val Val Asn Glu Ala Leu Asp 
    50                  55                  60                  


Lys Lys Ser Arg Leu Tyr Thr Pro Phe Asn Asn Gln Lys Val Ile Ile 
65                  70                  75                  80  


Asp Lys Asn Leu Gln Arg Tyr Ala Asn Asn Leu Lys Arg Cys Tyr Ile 
                85                  90                  95      


Asn Phe Val Lys Gln Tyr Val Asn Asn Lys Ser Phe Asn Tyr Lys Ala 
            100                 105                 110         


Met Gln Phe Ile Pro Asp Ile Gln Asn Pro Lys Thr Asn Asp Ala Val 
        115                 120                 125             


Asn Tyr Arg Thr Asp Arg Asp Asn Val Tyr Asn Lys Asn Lys Tyr Tyr 
    130                 135                 140                 


Asp Lys Gln Thr Lys Ser Lys Ser Lys Lys Phe Ile Tyr Glu Lys Ile 
145                 150                 155                 160 


Val Ile Pro Gln Asn Glu Gln Asn Ile Val Ile Ser Ala Leu Val Asn 
                165                 170                 175     


Cys Ser Leu Arg Lys Ser Leu Arg Lys Asp Val Ser Tyr Lys Thr Lys 
            180                 185                 190         


Ser Gly Glu Ile Lys Thr Tyr Asn Leu Pro Glu Leu Val Lys Lys Ser 
        195                 200                 205             


Met Arg Phe Tyr Cys Leu Glu Gly Gln Arg Glu Pro Asp Glu Lys Glu 
    210                 215                 220                 


Lys Tyr Glu Met Tyr Ile Leu Phe Ser Tyr Met Lys Glu Asp Lys Arg 
225                 230                 235                 240 


Thr Lys Asn Thr Asp Leu Leu Val Lys Ser Ile Ser Asn Gln Asn Thr 
                245                 250                 255     


Lys Val Lys Val Glu Asp Ile Asp Gly Asn Lys Leu Leu Lys Leu Ser 
            260                 265                 270         


Ile Ala Asp Thr Lys Lys Lys Pro Leu Trp Glu Tyr Leu Ile Lys Tyr 
        275                 280                 285             


Ala Asp Ser Ser Arg Gln Arg Glu Leu Met Tyr Asp Ile Arg Lys Lys 
    290                 295                 300                 


Ile Ile Leu Tyr Val Ala Gly Ile Glu Glu Tyr Glu Asn Ile Lys Glu 
305                 310                 315                 320 


Asp Ser Gly Leu Ser Lys Val Ser Trp Ser Lys Tyr Asn Ile Ser Asp 
                325                 330                 335     


Asn Lys Met Phe Phe Asp Ile Asn Ser Cys Thr Asp Lys Arg Lys Gln 
            340                 345                 350         


Asn Leu Glu Ile Lys Ile Arg Glu Ala Asn Ile Glu His Tyr Arg Asn 
        355                 360                 365             


Ala Ser Ser Lys Leu Cys Asp Asp Glu Ser Ile Phe Trp Phe Gln His 
    370                 375                 380                 


Phe Glu Gly Val Ile Glu Thr Leu Phe Ser Lys Lys Ser Lys Ile Ser 
385                 390                 395                 400 


Glu Glu Arg Leu Gly Cys Thr Tyr Ile Cys Asp Tyr Leu Trp Lys Asp 
                405                 410                 415     


Phe Leu Ser Tyr Leu Ala Ala Lys Tyr Ile Asp Leu Gly Lys Gly Val 
            420                 425                 430         


Tyr His Phe Thr Met Lys Asp Lys Leu Asp Met Leu Asn Lys Asn Glu 
        435                 440                 445             


Ala Val Thr Asp Leu Arg Phe Gly Ile Val Ser Glu Lys Tyr Glu Lys 
    450                 455                 460                 


Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Glu Leu 
465                 470                 475                 480 


Asp Arg Asn Ile Ala Ala Tyr Val Thr Phe Ala Ala Asp Ile Phe Ala 
                485                 490                 495     


Lys Ser Val Ile Lys Ser Asp Tyr Arg Thr Lys Lys Asp Asn Asn Ser 
            500                 505                 510         


Asp Val Leu Gln Tyr Ser Asp Lys Glu Phe Arg Asn Ser Glu Val Ile 
        515                 520                 525             


Arg Asp Asn Ala Glu Lys Asn Ile Leu Gln Tyr Trp Gly Gly Tyr Ser 
    530                 535                 540                 


Arg Trp Gly Thr Glu Asn Ser Lys Leu Pro Glu Asn Asn Lys Val Ser 
545                 550                 555                 560 


Asp Phe Gly Lys Leu Asn Val Ser Asp Leu Cys Ile Asp Ile Lys Lys 
                565                 570                 575     


His Leu Ala Gly Ile Arg Asn Ser Ser Val His Tyr Thr Thr Lys Ile 
            580                 585                 590         


Lys Asn Glu Ser Ala Ala Asp Gly Ser Asn Val Lys Ile Leu Phe Glu 
        595                 600                 605             


Lys Asp Leu Ala Asp Ile Asn Ile Ile Tyr Ala Asp Lys Tyr Tyr Ser 
    610                 615                 620                 


Asn Asn Val Trp Met Phe Tyr Ser Leu Glu Asp Ile Asn Lys Leu Ile 
625                 630                 635                 640 


Ala Phe Leu Tyr Lys Glu Lys Arg Val Ile Arg Gln Val Gln Ile Pro 
                645                 650                 655     


Ser Phe Ser Arg Ile Leu Lys Arg Lys Ala Met Gln Asp Val Ile Asn 
            660                 665                 670         


Glu Ile Phe Lys Asp Asp Phe Asp Glu Asn Ile Val Asn Pro Glu Leu 
        675                 680                 685             


Lys Glu Lys Tyr Arg Asn Ser Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
    690                 695                 700                 


Tyr Asn Ala Phe Ile Ile Gln Pro Glu Leu Lys Glu Lys Phe Lys Asp 
705                 710                 715                 720 


Lys Ile Lys Thr Met Lys Ser Glu Leu Tyr Asn Lys Leu Lys Thr Ile 
                725                 730                 735     


Asp Lys Lys Glu Tyr Lys Ala Leu Tyr Cys Met Leu Ser Asn Glu Glu 
            740                 745                 750         


Ser Ala Leu Lys Asn Phe Ala Asp Arg Ile Tyr Ser Val Asp Gly Asp 
        755                 760                 765             


Asn Val Ser Phe Ala Asp Ile Cys Lys Ile Leu Met Thr Asp Tyr Asn 
    770                 775                 780                 


Met Gln Asn Gln Glu Lys Lys Asn Ile Glu Ser Met Glu Gln Lys Lys 
785                 790                 795                 800 


Lys Asn Lys Gly Lys Asp Glu Asn Tyr Lys His Phe Pro Leu Leu Leu 
                805                 810                 815     


His Lys Val Leu Lys Glu Leu Phe Ile Glu Tyr Leu Lys Gln Thr His 
            820                 825                 830         


Glu Leu Glu Phe Leu Arg Asn Asn Ile Cys Ile Lys Ser Asp Val Thr 
        835                 840                 845             


Met Glu Ser Phe Glu Ser Gln Ile Lys Gly Val Glu Ile Tyr Lys Asp 
    850                 855                 860                 


Leu Lys Glu Lys Ile Asp Lys Asn Asn Ser Leu Leu Asp Trp Tyr Val 
865                 870                 875                 880 


Ile Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asn 
                885                 890                 895     


Ile Lys Asn Tyr Ile Gln Phe Ala Thr Asn Ile Asp Lys Arg Ala Glu 
            900                 905                 910         


Ser Val Lys Asn Leu Thr Glu Ser Gly Met Val Lys Arg Ile Gln Tyr 
        915                 920                 925             


Tyr Asp Asp Ile Val Arg Thr Leu Glu Phe Ser Ala Gln Tyr Ile Gly 
    930                 935                 940                 


Lys Ile Ser Asn Asn Ile Asn Asp Tyr Phe Asn Ser Glu Asp Glu Tyr 
945                 950                 955                 960 


Val Ser Phe Leu Ser Lys Tyr Val Gly Phe Ile Asn Asp Lys Ser Glu 
                965                 970                 975     


Asp Val Leu Thr Glu Leu Lys Asp Phe Cys Arg Glu Lys Ile Asn Asn 
            980                 985                 990         


Gly Ser Gln Ile Ile Gly Ile Tyr  Tyr Gly Gly Asp Asn  Val Ile Ile 
        995                 1000                 1005             


Asn Arg  Asn Val Ile Tyr Ala  Gln Met Tyr Ser Asn  Ala Glu Val 
    1010                 1015                 1020             


Phe Ser  Asn Ile Tyr Lys Lys  Val Thr Lys Asn Asp  Ile Ile Asn 
    1025                 1030                 1035             


Tyr Tyr  Glu Lys Gln Asn Asp  Leu Lys Asp Val Phe  Lys Ser Gly 
    1040                 1045                 1050             


Val Cys  Gln Asn Glu Asp Glu  Gln Arg Ser Leu Cys  Glu Phe Gln 
    1055                 1060                 1065             


Gln Leu  Lys Asn Arg Ile Glu  Leu Thr Glu Leu Ser  Thr Tyr Ala 
    1070                 1075                 1080             


Asp Met  Val Asn Asp Phe Met  Ala Gln Phe Val Glu  Trp Ala Tyr 
    1085                 1090                 1095             


Leu Arg  Glu Arg Asp Leu Met  Tyr Phe Gln Leu Gly  Ile His Tyr 
    1100                 1105                 1110             


Ile Arg  Leu Phe Tyr Ser Asp  Asn Val Leu Asp Glu  Lys Tyr His 
    1115                 1120                 1125             


Lys Leu  Ser Asp Asn Val Ile  Asp Ile Glu Glu Gly  Ala Leu Leu 
    1130                 1135                 1140             


Tyr Gln  Ile Val Ala Met Tyr  Asp Tyr Glu Leu Arg  Ile Phe Glu 
    1145                 1150                 1155             


Thr Asp  Asn Ser Gly Asn Ala  Lys Arg Ile Gly Gln  Gly Gly Pro 
    1160                 1165                 1170             


Gly Lys  Ser Ile Pro Val Phe  Leu Lys Lys Tyr Cys  Ser Gly Thr 
    1175                 1180                 1185             


Asp Val  Tyr Glu Cys Gly Leu  Glu Leu Phe Glu Asp  Ile Asn Gln 
    1190                 1195                 1200             


His Glu  His Ile Ile Arg Phe  Arg Asn Asp Ile Ala  His Met Arg 
    1205                 1210                 1215             


Tyr Met  Ser Asn Gln Ala Met  Asn Ile Met Ser Ile  Val Ser Asn 
    1220                 1225                 1230             


Ile Tyr  Lys Ser Phe Phe Ala  Tyr Asp Thr Lys Leu  Lys Lys Ser 
    1235                 1240                 1245             


Ile Ser  Leu Val Phe Lys Asn  Ile Leu Met Arg Tyr  Gly Val Ile 
    1250                 1255                 1260             


Ala Asp  Leu Val Phe Ser Tyr  Asn Asn Lys Asn Gln  Ser Ile Lys 
    1265                 1270                 1275             


Asp Asp  Met Asp Ile Asn Ile  Ile Asn Ile Lys Asn  Leu Lys Ser 
    1280                 1285                 1290             


Asp Lys  Tyr Val Tyr Lys Ile  Val Asn Glu Asp Ile  Val Lys Gln 
    1295                 1300                 1305             


Val Glu  Ile Glu Ile Arg Asn  Gln Val Phe Leu Glu  Gln Leu His 
    1310                 1315                 1320             


Asn Leu  Leu Tyr Phe Ser Arg  
    1325                 1330 


<210>  837
<211>  1143
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  837

Met Arg Val Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Val Tyr Ser Gly 
            20                  25                  30          


Gln Pro Val Ser Asn Glu Thr Cys Asn Ile Leu Pro Glu Lys Lys Arg 
        35                  40                  45              


Gln Ser Phe Asp Leu Ser Ile Glu Asn Lys Thr Leu Lys Arg Arg Asp 
    50                  55                  60                  


Asp Val Asp Lys Thr Lys Lys Gly Lys Tyr Asp Ile Val Arg Lys Ile 
65                  70                  75                  80  


Ile Lys Tyr Gly Glu Leu Pro Gln Ser Ile Asn Asp Val Asp Ile Leu 
                85                  90                  95      


Glu Phe Leu Asn His Lys Phe Gln Lys Pro Val Lys Tyr Trp Lys Asn 
            100                 105                 110         


Gly Lys Glu Glu Ser Phe Asn Leu Thr Leu Leu Ile Val Glu Ala Val 
        115                 120                 125             


Lys Thr Gln Asp Arg Gln Lys Leu Gln Pro Tyr Tyr Asp Trp Lys Thr 
    130                 135                 140                 


Trp Tyr Ile Gln Thr Lys Ser Asp Leu Leu Lys Lys Ser Ile Glu Asn 
145                 150                 155                 160 


Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg Lys Lys Ala Leu 
                165                 170                 175     


Leu Ala Trp Glu Thr Glu Phe Thr Thr Ser Gly Lys Ile Asp Leu Thr 
            180                 185                 190         


His Tyr His Lys Val Tyr Met Thr Asp Val Leu Cys Thr Ala Leu Gln 
        195                 200                 205             


Lys Val Glu Pro Ser Thr Asp Lys Lys Gly Lys Ile Asn Thr Asn Ala 
    210                 215                 220                 


Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Thr His Gln Pro Ala Ile 
225                 230                 235                 240 


Phe Gly Thr Arg Gln Ala Pro Asn Asn Val Asn Arg Ala Asp Asp Arg 
                245                 250                 255     


Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu Glu His Tyr Phe 
            260                 265                 270         


Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Ala Asp Asp Ile Glu His 
        275                 280                 285             


Tyr Leu Lys Thr Gln Thr Leu Lys Thr Thr Ile Glu Lys Gln Leu Val 
    290                 295                 300                 


Asn Ala Ile Arg Ala Asn Ile Ile Gln Gln Gly Lys Thr Asn His His 
305                 310                 315                 320 


Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile Arg Ile Lys Thr 
                325                 330                 335     


Asn Glu Ala Phe Val Leu Asn Leu Thr Gly Thr Cys Ala Phe Ala Ala 
            340                 345                 350         


Asn Asn Ile Arg Asn Met Val Asp Asn Glu Gln Thr Asn Asp Ile Leu 
        355                 360                 365             


Gly Lys Gly Asp Phe Ile Lys Ser Leu Leu Lys Asp Asn Thr Asn Gly 
    370                 375                 380                 


Gln Leu Tyr Ser Phe Phe Phe Gly Glu Ser Leu Ser Thr Asn Lys Ala 
385                 390                 395                 400 


Glu Lys Glu Thr Gln Leu Trp Gly Ile Arg Gly Ala Val Gln Gln Ile 
                405                 410                 415     


Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu Lys Thr Val Phe 
            420                 425                 430         


Asn Ile Ser Asn Phe Glu Asn Pro Thr Ile Thr Asp Pro Lys Gln Gln 
        435                 440                 445             


Thr Asn Tyr Ala Asp Thr Ile Tyr Lys Ala Leu Phe Ile Lys Glu Leu 
    450                 455                 460                 


Glu Lys Ile Pro Asn Ala Phe Ala Gln Gln Leu Lys Thr Gly Gly Ala 
465                 470                 475                 480 


Leu Ser Tyr Tyr Thr Ile Glu Asn Leu Lys Ser Leu Leu Thr Thr Phe 
                485                 490                 495     


Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala Pro Gly Phe Lys 
            500                 505                 510         


Lys Val Phe Asn Gly Gly Ile Asn Tyr Gln Asn Ala Lys Gln Asp Glu 
        515                 520                 525             


Ser Phe Tyr Glu Leu Met Leu Glu Arg Tyr Leu Arg Lys Glu Asn Phe 
    530                 535                 540                 


Ala Glu Glu Ala Tyr Asn Ala Arg Tyr Phe Leu Leu Lys Leu Ile Tyr 
545                 550                 555                 560 


Asn Asn Leu Phe Leu Pro Gly Phe Thr Arg Asp Arg Lys Ala Phe Ala 
                565                 570                 575     


Asp Ser Val Gly Phe Val Gln Met Gln Asn Lys Lys Gln Ala Glu Lys 
            580                 585                 590         


Val Asn Pro Lys Lys Arg Glu Ala Tyr Ala Phe Glu Ala Val Arg Pro 
        595                 600                 605             


Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala Tyr Val Gln Ser 
    610                 615                 620                 


Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys Ala Thr Asp Glu 
625                 630                 635                 640 


Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val Phe Val Lys Gly 
                645                 650                 655     


Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe Val Gln Val Pro 
            660                 665                 670         


Gln Pro Gln Leu Thr Ala Thr Ala Ser Asn Gln Gln Lys Ala Asp Lys 
        675                 680                 685             


Leu Asn Gln Leu Glu Ala Ser Ile Thr Ala Asp Cys Lys Leu Thr Pro 
    690                 695                 700                 


Gln Tyr Ala Lys Ala Asp Asn Ala Thr His Ile Ala Phe Tyr Val Phe 
705                 710                 715                 720 


Cys Lys Leu Leu Asp Ala Gly His Leu Ser Asn Leu Arg Asn Glu Leu 
                725                 730                 735     


Ile Lys Phe Arg Glu Ser Val Asn Glu Phe Lys Phe His His Leu Leu 
            740                 745                 750         


Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val Val Pro Thr Asp 
        755                 760                 765             


Tyr Arg Asp Leu Tyr Ser Ser Glu Ala Asp Cys Leu Ala Arg Leu Arg 
    770                 775                 780                 


Pro Phe Ile Glu Gln Gly Ala Asp Ile Thr Asn Trp Ser Asp Leu Phe 
785                 790                 795                 800 


Val Gln Ser Asp Lys His Ser Pro Val Ile His Ala Asn Ile Glu Leu 
                805                 810                 815     


Ser Val Lys Tyr Gly Thr Thr Lys Leu Leu Glu Gln Ile Ile Asn Lys 
            820                 825                 830         


Asp Pro Gln Phe Lys Thr Thr Glu Ala Asn Phe Thr Ala Trp Asn Thr 
        835                 840                 845             


Ala Gln Lys Ser Ile Glu Gln Leu Ile Lys Gln Arg Glu Asp His His 
    850                 855                 860                 


Glu Gln Trp Val Lys Ala Lys Asn Ala Asp Asp Lys Glu Lys Gln Glu 
865                 870                 875                 880 


Arg Lys Arg Glu Lys Ser Asn Phe Ala Gln Lys Phe Ile Glu Lys His 
                885                 890                 895     


Gly Asp Asp Tyr Leu Asp Ile Cys Asp Tyr Ile Asn Thr Tyr Asn Trp 
            900                 905                 910         


Leu Asp Asn Lys Met His Phe Val His Leu Asn Arg Leu His Gly Leu 
        915                 920                 925             


Thr Ile Glu Leu Leu Gly Arg Met Ala Gly Phe Val Ala Leu Phe Asp 
    930                 935                 940                 


Arg Asp Phe Gln Met Leu Asp Ala Lys Arg Ile Ser Asp Leu Tyr Gln 
945                 950                 955                 960 


Leu Lys Ser Phe Ile Ser Phe Arg Glu Ile Thr Ser Glu Leu Asp Lys 
                965                 970                 975     


Asn Asn Asp Ile Thr Glu Ile Asn Leu Ile Lys Asp Lys Glu Ile Ile 
            980                 985                 990         


Lys Arg Asp Gly Thr Pro Ile Thr  Glu Ala Asp Arg Asn  Ser Leu Lys 
        995                 1000                 1005             


Ser Cys  Ile Gln Ser Lys Arg  Glu Tyr Tyr Gln Lys  Thr Tyr Phe 
    1010                 1015                 1020             


Lys Glu  His Thr Asn Pro Phe  Thr Asp Arg Asn Tyr  Ile Ala His 
    1025                 1030                 1035             


Phe Asn  Tyr Leu Ser Thr Asn  Thr Gly Asn His Ser  Leu Ile Lys 
    1040                 1045                 1050             


Leu Ile  Asn Lys Leu Arg Asp  Leu Leu His Tyr Asp  Arg Lys Leu 
    1055                 1060                 1065             


Lys Asn  Ala Val Ser Lys Ala  Phe Ile Asp Leu Phe  Asp Lys His 
    1070                 1075                 1080             


Gly Met  Ile Leu Lys Leu Lys  Leu Asn Thr Asp His  Gln Leu Glu 
    1085                 1090                 1095             


Val Glu  Ser Leu Glu Pro Lys  Lys Ile Tyr His Leu  Gly Ser Ser 
    1100                 1105                 1110             


Ala Lys  Asp Lys Pro Glu Tyr  Gln Tyr Cys Thr Asn  Gln Val Met 
    1115                 1120                 1125             


Met Ala  Tyr Cys Asn Met Cys  Arg Ser Leu Leu Glu  Met Lys Lys 
    1130                 1135                 1140             


<210>  838
<211>  1330
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  838

Met Lys Arg Glu Lys Asn Ile Thr Ile Met Lys Ile Ser Lys Val Asn 
1               5                   10                  15      


His Arg Arg Met Ala Val Ala Leu Asn Gly Asp Lys Ser Glu Leu Gly 
            20                  25                  30          


Gly Ile Leu Tyr Glu Ala Pro Val Gln Lys Asp Lys Asn Gly Asn Tyr 
        35                  40                  45              


Asn Asp Val Ile Ala Glu Thr Gly Lys Val Val Asn Glu Ala Leu Asp 
    50                  55                  60                  


Lys Lys Ser Arg Leu Tyr Thr Pro Phe Asn Asn Gln Lys Val Ile Ile 
65                  70                  75                  80  


Asp Lys Asn Leu Gln Arg Tyr Ala Asn Asn Leu Lys Arg Cys Tyr Ile 
                85                  90                  95      


Asn Phe Val Lys Gln Tyr Val Asn Asn Lys Ser Phe Asn Tyr Lys Ala 
            100                 105                 110         


Met Gln Phe Ile Pro Asp Ile Gln Asn Pro Lys Thr Asn Asp Ala Val 
        115                 120                 125             


Asn Tyr Arg Thr Asp Arg Asp Asn Val Tyr Asn Lys Asn Lys Tyr Tyr 
    130                 135                 140                 


Asp Lys Gln Thr Lys Ser Lys Ser Lys Lys Phe Ile Tyr Glu Lys Ile 
145                 150                 155                 160 


Val Ile Pro Gln Asn Glu Gln Asn Ile Val Ile Ser Ala Leu Val Asn 
                165                 170                 175     


Cys Ser Leu Arg Lys Ser Leu Arg Lys Asp Val Ser Tyr Lys Thr Lys 
            180                 185                 190         


Ser Gly Glu Ile Lys Thr Tyr Asn Leu Pro Glu Leu Val Lys Lys Ser 
        195                 200                 205             


Met Arg Phe Tyr Cys Leu Glu Gly Gln Arg Glu Pro Asp Glu Lys Glu 
    210                 215                 220                 


Lys Tyr Glu Met Tyr Ile Leu Phe Ser Tyr Met Lys Glu Asp Lys Arg 
225                 230                 235                 240 


Thr Lys Asn Thr Asp Leu Leu Val Lys Ser Ile Ser Asn Gln Asn Thr 
                245                 250                 255     


Lys Val Lys Val Glu Asp Ile Asp Gly Asn Lys Leu Leu Lys Leu Ser 
            260                 265                 270         


Ile Ala Asp Thr Lys Lys Glu Pro Leu Trp Glu Tyr Leu Ile Lys Tyr 
        275                 280                 285             


Ala Asp Ser Ser Arg Gln Arg Glu Leu Met Tyr Asp Ile Arg Lys Lys 
    290                 295                 300                 


Ile Val Leu Tyr Val Val Gly Ile Glu Glu Tyr Glu Asn Ile Lys Glu 
305                 310                 315                 320 


Asp Ser Gly Leu Ser Lys Val Ser Trp Ser Lys Tyr Asn Ile Ser Asp 
                325                 330                 335     


Asn Lys Met Phe Phe Asp Ile Asn Ser Cys Thr Asp Lys Arg Lys Gln 
            340                 345                 350         


Asn Leu Glu Ile Lys Ile Arg Glu Ala Asn Ile Glu His Tyr Arg Asn 
        355                 360                 365             


Ala Ser Ser Lys Leu Cys Asp Asp Glu Ser Ile Phe Trp Phe Gln His 
    370                 375                 380                 


Phe Glu Gly Val Ile Glu Thr Leu Phe Ser Lys Lys Ser Lys Ile Ser 
385                 390                 395                 400 


Glu Glu Arg Leu Gly Cys Ala Tyr Ile Cys Asp Tyr Leu Trp Lys Asp 
                405                 410                 415     


Phe Leu Ser Tyr Leu Ala Ala Lys Tyr Ile Asp Leu Gly Lys Gly Val 
            420                 425                 430         


Tyr His Phe Thr Met Lys Asp Lys Leu Asp Met Leu Asn Lys Asn Glu 
        435                 440                 445             


Ala Val Thr Asp Leu Arg Phe Gly Ile Val Ser Glu Lys Tyr Glu Lys 
    450                 455                 460                 


Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Glu Leu 
465                 470                 475                 480 


Asp Arg Asn Ile Ala Ala Tyr Val Thr Phe Ala Ala Asp Ile Phe Ala 
                485                 490                 495     


Lys Ser Val Ile Lys Ser Asp Tyr Arg Thr Lys Lys Asp Asn Asn Ser 
            500                 505                 510         


Asp Val Leu Gln Tyr Ser Asp Lys Glu Phe Arg Asn Ser Glu Val Ile 
        515                 520                 525             


Arg Asp Asn Ala Glu Lys Asn Ile Leu Gln Tyr Trp Gly Gly Tyr Ser 
    530                 535                 540                 


Arg Trp Gly Thr Glu Asn Ser Lys Leu Pro Glu Asn Asn Lys Val Ser 
545                 550                 555                 560 


Asp Phe Gly Lys Leu Asp Val Ser Asp Leu Cys Ile Asp Ile Lys Lys 
                565                 570                 575     


His Leu Ala Gly Ile Arg Asn Ser Ser Val His Tyr Thr Thr Lys Ile 
            580                 585                 590         


Lys Asn Glu Ser Ala Ala Asp Gly Ser Asn Val Lys Ile Leu Phe Glu 
        595                 600                 605             


Lys Asp Leu Ala Asp Ile Asn Ile Ile Tyr Ala Asp Lys Tyr Tyr Ser 
    610                 615                 620                 


Asn Asn Val Trp Met Phe Tyr Ser Leu Glu Asp Ile Asn Lys Leu Ile 
625                 630                 635                 640 


Ala Phe Leu Tyr Lys Glu Lys Arg Val Ile Arg Gln Val Gln Ile Pro 
                645                 650                 655     


Ser Phe Ser Arg Ile Leu Lys Arg Lys Ala Met Gln Asp Val Ile Asn 
            660                 665                 670         


Glu Ile Phe Lys Asp Asp Phe Asp Glu Asn Ile Val Asn Pro Glu Leu 
        675                 680                 685             


Lys Glu Lys Tyr Arg Asn Ser Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
    690                 695                 700                 


Tyr Asn Ala Phe Ile Ile Gln Pro Glu Leu Lys Glu Lys Phe Lys Asp 
705                 710                 715                 720 


Lys Ile Lys Thr Met Lys Ser Glu Leu Tyr Asn Lys Leu Lys Thr Ile 
                725                 730                 735     


Asp Lys Lys Glu Tyr Lys Ala Leu Tyr Cys Met Leu Ser Asn Glu Glu 
            740                 745                 750         


Ser Ala Leu Lys Asn Phe Ala Asp Arg Ile Tyr Ser Val Asp Gly Asp 
        755                 760                 765             


Asn Val Ser Phe Ala Asp Ile Cys Lys Ile Leu Met Thr Asp Tyr Asn 
    770                 775                 780                 


Met Gln Asn Gln Glu Lys Lys Asn Ile Glu Ser Met Glu Gln Lys Lys 
785                 790                 795                 800 


Lys Asn Lys Gly Lys Asp Glu Asn Tyr Lys His Phe Pro Leu Leu Leu 
                805                 810                 815     


His Lys Val Leu Lys Glu Leu Phe Ile Glu Tyr Leu Lys Gln Thr His 
            820                 825                 830         


Glu Leu Glu Phe Leu Arg Asn Asn Ile Cys Ile Lys Ser Asp Val Thr 
        835                 840                 845             


Met Glu Ser Phe Glu Ser Gln Ile Lys Gly Val Glu Ile Tyr Lys Asp 
    850                 855                 860                 


Leu Lys Glu Lys Ile Asp Lys Asn Asn Ser Leu Leu Asp Trp Tyr Val 
865                 870                 875                 880 


Ile Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asn 
                885                 890                 895     


Ile Lys Asn Tyr Ile Gln Phe Ala Thr Asn Ile Asp Lys Arg Ala Glu 
            900                 905                 910         


Ser Val Lys Asn Leu Thr Glu Ser Gly Met Val Lys Arg Ile Gln Tyr 
        915                 920                 925             


Tyr Asp Asp Ile Val Arg Thr Leu Glu Phe Ser Ala Gln Tyr Ile Gly 
    930                 935                 940                 


Lys Ile Ser Asn Asn Ile Asn Asp Tyr Phe Asn Ser Glu Asp Glu Tyr 
945                 950                 955                 960 


Val Ser Phe Leu Ser Lys Tyr Val Gly Phe Ile Asn Asp Lys Ser Glu 
                965                 970                 975     


Asp Val Leu Thr Glu Leu Lys Asp Phe Cys Arg Glu Lys Ile Asn Asn 
            980                 985                 990         


Gly Ser Gln Ile Ile Gly Ile Tyr  Tyr Gly Gly Asp Asn  Val Ile Ile 
        995                 1000                 1005             


Asn Arg  Asn Val Ile Tyr Ala  Gln Met Tyr Ser Asn  Ala Glu Val 
    1010                 1015                 1020             


Phe Ser  Asn Ile Tyr Lys Lys  Val Thr Lys Asn Asp  Ile Ile Asn 
    1025                 1030                 1035             


Tyr Tyr  Glu Lys Gln Asn Asp  Leu Lys Asp Val Phe  Lys Arg Gly 
    1040                 1045                 1050             


Val Cys  Gln Asn Glu Gly Glu  Gln Arg Ser Leu Cys  Glu Phe Gln 
    1055                 1060                 1065             


Gln Leu  Lys Asn Arg Ile Glu  Leu Thr Glu Leu Ser  Thr Tyr Ala 
    1070                 1075                 1080             


Asp Met  Val Asn Asp Phe Met  Ala Gln Phe Val Glu  Trp Ala Tyr 
    1085                 1090                 1095             


Leu Arg  Glu Arg Asp Leu Met  Tyr Phe Gln Leu Gly  Ile His Tyr 
    1100                 1105                 1110             


Ile Arg  Leu Phe Tyr Ser Asp  Asn Val Leu Asp Glu  Lys Tyr His 
    1115                 1120                 1125             


Lys Leu  Ser Asp Asn Val Ile  Asp Ile Glu Glu Gly  Ala Leu Leu 
    1130                 1135                 1140             


Tyr Gln  Ile Val Ala Met Tyr  Asp Tyr Glu Leu Arg  Ile Phe Glu 
    1145                 1150                 1155             


Thr Asp  Asn Ser Gly Asn Ala  Lys Arg Ile Gly Gln  Gly Gly Pro 
    1160                 1165                 1170             


Gly Lys  Ser Ile Pro Val Phe  Leu Lys Lys Tyr Cys  Asn Gly Thr 
    1175                 1180                 1185             


Asp Val  Tyr Glu Cys Gly Leu  Glu Leu Phe Glu Asp  Ile Asn Gln 
    1190                 1195                 1200             


His Glu  His Ile Ile Arg Phe  Arg Asn Asp Ile Ala  His Met Arg 
    1205                 1210                 1215             


Tyr Met  Ser Asn Gln Ala Met  Asn Ile Met Ser Ile  Val Ser Asn 
    1220                 1225                 1230             


Ile Tyr  Lys Ser Phe Phe Val  Tyr Asp Thr Lys Leu  Lys Lys Ser 
    1235                 1240                 1245             


Ile Ser  Leu Val Phe Lys Asn  Ile Leu Met Arg Tyr  Gly Val Ile 
    1250                 1255                 1260             


Ala Asp  Leu Val Phe Ser Tyr  Asn Asn Lys Asn Gln  Ser Ile Lys 
    1265                 1270                 1275             


Asp Asp  Met Asp Ile Asn Ile  Ile Asn Ile Lys Asn  Leu Lys Ser 
    1280                 1285                 1290             


Asp Lys  Tyr Val Tyr Lys Ile  Val Asn Glu Asp Ile  Val Lys Gln 
    1295                 1300                 1305             


Val Glu  Ile Glu Ile Arg Asn  Gln Val Phe Leu Glu  Gln Leu His 
    1310                 1315                 1320             


Asn Leu  Leu Tyr Phe Ser Arg  
    1325                 1330 


<210>  839
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  839

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Leu Tyr Gln Ile Val  Ser Ala Phe Asn Phe  Gly Ser Lys 
    1205                 1210                 1215             


Leu Leu  Tyr Ile Ser Glu Asp  Gly Arg Trp Lys Met  Ala Gly Gly 
    1220                 1225                 1230             


Ala Phe  Pro Gly Lys Tyr Gly  Arg Phe Glu Asn Asp  Tyr Asn His 
    1235                 1240                 1245             


Arg Thr  Ser Leu Ser Lys Val  Ile Arg Leu Phe Glu  Asn Glu Ser 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ile Ile Tyr  Trp Arg Asp Tyr Val  Asp His Met 
    1265                 1270                 1275             


Lys Tyr  Tyr Val Asn Gln Asn  Gln Ser Ile Met Glu  Ile Tyr Ser 
    1280                 1285                 1290             


Ala Phe  Tyr Ser Lys Val Leu  Gly Tyr Ser Ala Lys  Leu Arg Lys 
    1295                 1300                 1305             


Ser Val  Val Phe Asn Leu Gln  Ala Ala Leu Glu Lys  His His Ile 
    1310                 1315                 1320             


Asn Pro  Glu Cys Ile Trp Met  Thr Ser Asp Gly Lys  Cys Ala Asp 
    1325                 1330                 1335             


Ile Lys  Leu Met Lys Asn Leu  Glu Ser Gln Lys Phe  Thr Tyr Lys 
    1340                 1345                 1350             


Leu Ala  Lys Arg Glu Gly Glu  Lys Thr Glu Arg Lys  Ile Cys Met 
    1355                 1360                 1365             


Asn Ala  Leu Asn Glu Asn Phe  Leu Lys Thr Ile Arg  Thr Ser Leu 
    1370                 1375                 1380             


Glu Tyr  Lys Lys 
    1385         


<210>  840
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  840

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Thr Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Lys Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Glu 
        755                 760                 765             


Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Lys Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Ile  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Arg Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1400                 1405                 1410         


<210>  841
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  841

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  842
<211>  1349
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  842

Met Lys Ile Ser Lys Val Asn His Thr Lys Ser Ala Val Ala Lys Asn 
1               5                   10                  15      


Glu Gly Met Ile Lys Gly Ile Leu Tyr Gln Asp Pro Gly Ser Glu Glu 
            20                  25                  30          


Asp Leu Gln Lys Arg Phe Ser Thr Leu Asn Arg Asn Ala Gln Arg Leu 
        35                  40                  45              


Tyr Lys Ile Leu Asn Gln Val Gln Val Gly Glu Lys Gln Asn Arg Arg 
    50                  55                  60                  


Ser Arg Tyr Glu Val Ile Ile Asn Gly Lys Asp Gly Leu Asn Asn Lys 
65                  70                  75                  80  


Leu Gln Asp Leu Leu Phe Ile Arg Gln Asp Asn Arg Leu Ala Val Lys 
                85                  90                  95      


Asn Ser Glu Ala Val Leu Lys Lys Leu His Ser Trp Asn Leu Gln Val 
            100                 105                 110         


Lys Gly Lys Glu Val Ser Asn Asp Asp Leu Asp Asp Ile Leu Thr Leu 
        115                 120                 125             


Tyr Leu Arg Lys Ser Leu Arg Lys Gly Lys Ala Gly Leu Arg Thr Leu 
    130                 135                 140                 


Phe Arg Asn Ser Gly Asn Thr Asp Ile Ser Gln Glu Asp Gln Glu Lys 
145                 150                 155                 160 


Ile Ser Glu Phe Val Thr Ile Leu Arg Glu Asp Tyr Thr Lys Asn Asn 
                165                 170                 175     


Phe Gly Lys Lys Ile Arg Lys Ser Ile Glu Asn Gln Asn Leu Ile Val 
            180                 185                 190         


Gln Pro Val Gln Thr Gly Asn Arg Gly Val Leu Ala Leu Ser Thr Lys 
        195                 200                 205             


Lys Asp Ser Arg Ser Gly Arg Glu Lys Gln Ser Phe Ser Asp Phe Leu 
    210                 215                 220                 


Thr Asn Tyr Ala Asn Leu Asp Ser Glu Lys Arg Met Asp Leu Leu Arg 
225                 230                 235                 240 


Lys Leu Arg Arg Leu Val Asp Leu Tyr Phe Asn Ala Asp Gly Asn Thr 
                245                 250                 255     


Asp Ser Leu Thr Leu Pro Lys Glu Val Asn Ile Glu Pro Asp Tyr Asn 
            260                 265                 270         


Val Trp Ala Thr His Glu Ala Gly Lys Thr Asn Asn Lys Thr Phe Ala 
        275                 280                 285             


Glu Tyr Pro Glu Ile Leu Ser Gln Gly Asp Asp Ser Asn Ser Gly Glu 
    290                 295                 300                 


Arg Lys Thr Leu Asp Ser Val Glu Val Arg Glu Ala Arg Gly Ser Leu 
305                 310                 315                 320 


Lys Glu Ser Ile Arg Lys Arg Asn Ile Glu Cys Tyr Arg Lys Ser Leu 
                325                 330                 335     


Ala Ile Ile Lys Glu Asn Lys Glu Leu Phe Phe Thr Asp Asp Glu Leu 
            340                 345                 350         


Asn His Tyr Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu 
        355                 360                 365             


Ser Thr Thr Gly Asn Gly Lys Arg Leu Thr Arg Glu Lys Leu Arg Ile 
    370                 375                 380                 


Gly Tyr Leu Ser Glu Lys Val Trp Lys Asp Cys Leu Asn Thr Met Ser 
385                 390                 395                 400 


Ile Lys Tyr Ile Ala Val Gly Lys Ala Val Tyr His Phe Ala Leu Asp 
                405                 410                 415     


Asp Leu Ala Asp Thr Glu Lys Asp Thr Asp Leu Leu Lys Ile Ala Asp 
            420                 425                 430         


Lys Ala Leu Asp Gly Ile Thr Ser Phe Asp Tyr Glu Glu Ile Lys Ala 
        435                 440                 445             


Asn Glu Thr Leu Gln Arg Glu Val Ala Val Asp Val Ser Phe Ala Ala 
    450                 455                 460                 


Asn Asn Leu Ser Arg Ala Thr Val Lys Thr Ile Lys Gly Lys Glu Asp 
465                 470                 475                 480 


Phe Leu Val Trp Asn Ala Lys Asp Ile Arg Glu Asn Met Arg Tyr Lys 
                485                 490                 495     


Glu Asp Gly Arg Thr Leu Lys Thr Ile Leu Gln Phe Phe Gly Gly Ala 
            500                 505                 510         


Ser Arg Trp Asp Leu Asn Leu Phe Lys Asn Ala Tyr Asn Val Ser Pro 
        515                 520                 525             


Asp Tyr Glu Ile Lys Phe Leu Asp Asp Leu Arg Lys Ile Ile Phe Phe 
    530                 535                 540                 


Leu Arg Asn Glu Ser Phe His Phe Thr Thr Gln Ala Thr Gly Asp Tyr 
545                 550                 555                 560 


Asp Trp Asn Thr Asn Leu Ile Gly Glu Met Phe Ala Glu Asp Ala Asp 
                565                 570                 575     


Val Cys Met Ala Leu Glu Lys Lys Lys Phe Tyr Ser Asn Asn Leu Pro 
            580                 585                 590         


Met Phe Tyr Asn Ser Ser Asp Leu Gln Lys Ile Leu Asp Phe Leu Tyr 
        595                 600                 605             


Lys Glu Asn Pro Ser Arg Ala Ser Gln Val Pro Ser Phe Lys Thr Val 
    610                 615                 620                 


Phe Val Arg Lys Asn Phe Pro Asp Phe Leu Ala Ser His Gly Phe Ser 
625                 630                 635                 640 


Phe Ala Gly Gly Asp Ala Glu Thr Arg Leu Lys Trp Gln Asn Ala Leu 
                645                 650                 655     


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ala Phe Leu Thr Ser Ser 
            660                 665                 670         


Asp Val Lys Asp Asp Phe Phe Lys Ala Leu Asp Gly Leu Pro Ala Glu 
        675                 680                 685             


Asn Glu Asp Ala Leu Asn Asp Phe Arg Arg Arg Cys Arg Asp Phe Lys 
    690                 695                 700                 


Asn Lys Lys Glu Tyr Gly Leu Pro Glu Ile Cys Gln Phe Ile Met Thr 
705                 710                 715                 720 


Glu Tyr Asn Glu Gln Asn Ala Gly Asn Arg Lys Val Arg Ser Ser Lys 
                725                 730                 735     


Ala Asp Gln Met Asn Pro Lys Ile Phe Gln His Tyr Arg Leu Leu Leu 
            740                 745                 750         


Met His Thr Leu Gln Ser Ala Phe Ser Ile Phe Leu Asp Arg Gln Asp 
        755                 760                 765             


Val Leu Lys Val Leu Lys His Ser Gly Arg Lys Arg Glu Leu Met Pro 
    770                 775                 780                 


Glu Glu Glu Phe Leu Asn Ser Trp Ser Ser Thr Met Tyr Lys Asp Thr 
785                 790                 795                 800 


Ile Asn Ala Val Lys Gly Ser Gln Lys Leu Gln Ala Trp Tyr Ile Thr 
                805                 810                 815     


Ala Arg Phe Leu Asn Ala Arg Thr Leu Asn Leu Leu Val Gly Ser Leu 
            820                 825                 830         


Arg Ser Tyr Ile Gln Tyr Ala Arg Asp Val Tyr Arg Arg Ala Gln Glu 
        835                 840                 845             


Thr Glu Asn Gln Val Ile Thr Tyr Glu Glu Asn Thr Val Gln Thr Cys 
    850                 855                 860                 


Glu Lys Val Leu Pro Val Leu Asp Leu Cys Met Lys Leu Ser Ser Val 
865                 870                 875                 880 


Tyr Ser Asn Lys Leu Thr Asp Tyr Phe Phe Asp Asn Glu Glu Tyr Ala 
                885                 890                 895     


Lys Tyr Leu Ser Asn Tyr Val Asn Phe Tyr Asn Ala Gln Val Gly Asp 
            900                 905                 910         


Gly Ser Thr Phe Ala Gln Leu Gln Ala Phe Asp Asp Lys Gly Leu Tyr 
        915                 920                 925             


Met Asp Lys Met Asn Pro Ile Ala Asn Arg Asn Ile Val Met Ala Lys 
    930                 935                 940                 


Leu Phe Gly Pro Val Ser Val Leu Ser Glu Thr Met Ser Pro Val Thr 
945                 950                 955                 960 


Glu Gln Asp Ile Lys Asp Tyr Tyr Asp Lys Arg Glu Glu Ile Ala Gly 
                965                 970                 975     


Tyr Met Val Lys Gly Gln Cys Ser Ser Lys Glu Glu Gln Glu Ser Val 
            980                 985                 990         


Ile Glu Tyr Gln Arg Leu Lys Asn  His Val Glu Leu Arg  Asp Ala Val 
        995                 1000                 1005             


Glu Phe  Gly Glu Ile Ile Asn  Glu Leu Leu Gly Gln  Leu Ile Asn 
    1010                 1015                 1020             


Trp Ser  Tyr Leu Arg Glu Arg  Asp Leu Leu Tyr Phe  Gln Leu Gly 
    1025                 1030                 1035             


Phe His  Tyr Leu Cys Leu Asn  Asn Asp Asp Ala Lys  Lys Pro Glu 
    1040                 1045                 1050             


Gly Tyr  Ile His Ile Thr Arg  Glu Asn Gly Thr Lys  Ile Asn Gly 
    1055                 1060                 1065             


Ala Ile  Leu Ser Gln Val Ala  Gly Met Tyr Ile Asn  Gly Ile Pro 
    1070                 1075                 1080             


Val Phe  Ala Pro Asp Lys Ala  Gly Lys Leu Thr Ala  Gln Ser Ser 
    1085                 1090                 1095             


Lys Gly  Ser Ala Gly Lys Lys  Ile Gly Ser Phe Gly  Ser Tyr Ala 
    1100                 1105                 1110             


Glu Arg  Ile Leu His Glu Asn  Lys Lys Glu Ala Gln  Glu Val Leu 
    1115                 1120                 1125             


Tyr Asn  Ala Gly Leu Glu Leu  Phe Glu Thr Leu Arg  Glu His Asp 
    1130                 1135                 1140             


Asn Val  Val His Val Arg Asn  Ala Ile Asp His Phe  Lys Tyr Tyr 
    1145                 1150                 1155             


Thr Val  Lys Lys Met Asp Asn  Gln Glu Asp Gly Thr  Pro His Ser 
    1160                 1165                 1170             


Ile Leu  Asp Tyr Tyr Ser Glu  Val Phe Asp Arg Phe  Phe Glu Tyr 
    1175                 1180                 1185             


Asp Val  Lys Tyr Gln Lys Thr  Val Val Ser Met Leu  Gln Asn Val 
    1190                 1195                 1200             


Leu Leu  Arg His Phe Val Leu  Phe Phe Pro Ser Phe  Ser Thr Gly 
    1205                 1210                 1215             


Lys Lys  Val Val Gly Ser Ala  Glu Val Lys Asp Arg  Ala Gln Ile 
    1220                 1225                 1230             


Ser Ala  Gln Thr Asn Gly Ile  Ser Ser Asp Thr Leu  Thr Tyr Lys 
    1235                 1240                 1245             


Ile Gln  Asp Cys Ser Asp Leu  Ile Ile Asp Ala Lys  Ser Glu Lys 
    1250                 1255                 1260             


Tyr Arg  Glu Val Ile Gly Lys  Ile Leu Tyr Tyr Pro  Tyr Pro Met 
    1265                 1270                 1275             


Pro Asp  Asp Ile Ile Gly Gly  Glu His Gln Lys Lys  Gly Gly Lys 
    1280                 1285                 1290             


Glu Glu  Asn Ser Arg Arg Lys  Ser Gly Arg Asn Pro  Gly Lys Phe 
    1295                 1300                 1305             


Arg Gln  Gly Lys Lys Glu Arg  Glu Gln Glu Glu Lys  Glu Leu Asn 
    1310                 1315                 1320             


Asn Tyr  Lys Lys Lys Asn Asn  Thr Ala Lys Ser Val  Gly Thr Ser 
    1325                 1330                 1335             


Ile Gly  Asp Ile Leu Asn Gly  Leu Asn Ile Lys 
    1340                 1345                 


<210>  843
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  843

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Lys Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Leu Tyr Gln Ile Val  Ser Ala Phe Asn Phe  Gly Ser Lys 
    1205                 1210                 1215             


Leu Leu  Tyr Ile Ser Glu Asp  Gly Arg Trp Lys Met  Ala Gly Gly 
    1220                 1225                 1230             


Ala Phe  Pro Gly Lys Tyr Gly  Arg Phe Glu Asn Asp  Tyr Asn His 
    1235                 1240                 1245             


Arg Thr  Ser Leu Ser Lys Val  Ile Arg Leu Phe Glu  Asn Glu Ser 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ile Ile Tyr  Trp Arg Asp Tyr Val  Asp His Met 
    1265                 1270                 1275             


Lys Tyr  Tyr Val Asn Gln Asn  Gln Ser Ile Met Glu  Ile Tyr Ser 
    1280                 1285                 1290             


Ala Phe  Tyr Ser Lys Val Leu  Gly Tyr Ser Ala Lys  Leu Arg Lys 
    1295                 1300                 1305             


Ser Val  Val Phe Asn Leu Gln  Ala Ala Leu Glu Lys  His His Ile 
    1310                 1315                 1320             


Asn Pro  Glu Cys Ile Trp Met  Thr Ser Asp Gly Lys  Cys Ala Asp 
    1325                 1330                 1335             


Ile Lys  Leu Met Lys Asn Leu  Glu Ser Gln Lys Phe  Thr Tyr Lys 
    1340                 1345                 1350             


Leu Ala  Lys Arg Glu Gly Glu  Lys Thr Glu Arg Lys  Ile Cys Met 
    1355                 1360                 1365             


Asn Ala  Leu Asn Glu Asn Phe  Leu Lys Thr Ile Arg  Thr Ser Leu 
    1370                 1375                 1380             


Glu Tyr  Lys Lys 
    1385         


<210>  844
<211>  931
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  844

Met Lys Val Thr Lys Ala Glu Lys Leu Arg Val Ala Val Ser Arg Lys 
1               5                   10                  15      


Leu Asn Asn Glu Asp Lys Arg Ala Val Leu Tyr Lys Thr Pro Asn Pro 
            20                  25                  30          


Gly Gln Thr Cys Gly Thr Val Lys Lys Gln Leu Ala Asn Arg Val Glu 
        35                  40                  45              


Arg Ala Asn Lys Leu Tyr Gly Val Phe Phe Arg Ser Asp Val Pro Glu 
    50                  55                  60                  


Thr Leu Gln Tyr His Phe Glu Glu Leu Val Thr Tyr Ala Ala Gln Ser 
65                  70                  75                  80  


Thr Ser Pro Asn Glu Phe Arg Gln Lys Ala Ser Gln Tyr Arg Glu Cys 
                85                  90                  95      


Glu Lys Lys Asp Lys Phe Gly Lys Met Arg Lys Tyr Pro Ile Phe Arg 
            100                 105                 110         


Cys Ser Tyr Ala Pro Ser Gly Lys Asn Met Lys Lys Val Met Glu Leu 
        115                 120                 125             


Tyr Val Arg Glu Arg Met Lys Asp Glu Trp Gln Ser Gln Ala Tyr Arg 
    130                 135                 140                 


Thr Ala Ala Ile Glu Ile Leu Leu Cys Ile Cys Asn Lys Asp Phe Ser 
145                 150                 155                 160 


Lys Gln Leu Ser Arg Val Asp Ala Arg Ile Phe Ala Asp Phe Tyr Asn 
                165                 170                 175     


Ala Ser Lys Ala Cys Pro Gln Pro Tyr Ile Gly Lys Ser Thr Gly Val 
            180                 185                 190         


Leu Glu Ala Ala Phe Thr Ser Val Met Lys Gln Met Ser Leu His Ala 
        195                 200                 205             


Lys Ala Asn Ala Ser Asn Lys Ile Trp Trp Leu Gln Asn Gln Leu Arg 
    210                 215                 220                 


Thr Ile Glu Leu Asn Lys Lys Ile Val Lys Ile Ser Asp Phe Lys Tyr 
225                 230                 235                 240 


Glu Tyr Ala Thr Glu Asp Arg Met Arg Ala Ile Leu Val Arg Met Arg 
                245                 250                 255     


Lys Ser Leu Lys Arg Gly Thr Asn Gly Asp Ile Ala Val Ala Leu Leu 
            260                 265                 270         


Gln Gly Ile Ala Gln Met Asn Gly Lys Thr Leu Ser Gly Val Leu Glu 
        275                 280                 285             


Glu Leu Ser Ala Asn Ser Glu Thr Lys Glu Gln Leu Ile Lys Phe Leu 
    290                 295                 300                 


Lys Ala Val His Glu Asp Tyr His Lys Thr Pro Ile Leu Lys Ala Ile 
305                 310                 315                 320 


Arg Asn Gln Asp Val Lys Val Gln Val His Glu Val Asp Pro Val Ser 
                325                 330                 335     


Pro Glu Gly Arg Ala Leu Asp Leu Ala Ser Ile Asn Val Ser Lys Gly 
            340                 345                 350         


Asn Glu Arg Lys Lys Tyr Lys Val Ala Leu Thr Gln Thr Leu Gly Asn 
        355                 360                 365             


Tyr Ala Lys Ser Pro Lys Asp Ala Thr Gln Thr Leu Lys Ala Ile Lys 
    370                 375                 380                 


Gly Val Leu Leu Asp Tyr Phe Met Trp Leu Asp Ser Asp Val Lys Ala 
385                 390                 395                 400 


Glu Phe Leu Glu Asp Asn Asn Leu Trp Lys Ile Pro Asn Arg Thr Glu 
                405                 410                 415     


Glu Tyr Phe Asp Asn Asn Phe Val Pro Ile Asp Asp Lys Lys Asp Asp 
            420                 425                 430         


Lys Ile Glu Ala Ile Glu Asp Phe Ala Ser Ile Trp Arg Gln Glu Arg 
        435                 440                 445             


Val Lys Asn Ser Arg Ile Lys Ala Arg Met Asn Tyr Val Asn Cys Gly 
    450                 455                 460                 


Lys Tyr Gln Gln Leu Ile Lys Gln Glu Thr Asp Asp Phe Arg Ile Cys 
465                 470                 475                 480 


Trp Ile Ser Tyr Ala Lys Asp Phe Val Glu Lys Asn Tyr Val Ser Lys 
                485                 490                 495     


Asn Arg Gln Phe Thr Gln Gly Asp Cys Phe Ser Thr Lys Met Leu Leu 
            500                 505                 510         


Glu Cys Trp Lys Glu Ile Ile Arg Phe Ile Cys Gly Lys Tyr Ile Asp 
        515                 520                 525             


Ile Gly Lys Ala Val Tyr His Phe Ala Met Pro Glu Thr Met Asn Ala 
    530                 535                 540                 


Arg Asp Ser Leu Ala Tyr Gly Val Leu Gly Glu Lys Tyr Lys Glu Gly 
545                 550                 555                 560 


Ile Ser Ser Phe Asp Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln 
                565                 570                 575     


Arg Asp Ile Ala Lys Ala Ala Val Ala Ala Ile His Ala Phe Ser Gly 
            580                 585                 590         


Ser Val Ile Asp Asp Lys Lys Pro Val Glu Asp Ile Leu Phe Ile Lys 
        595                 600                 605             


Asp Glu Glu Leu Gln Glu His Ala Lys Ala Asp Asp Val Ile Val Lys 
    610                 615                 620                 


Gln Ile Leu Arg Phe Tyr Gly Gly Phe Ser Ser Val Glu Gly Arg Glu 
625                 630                 635                 640 


Lys Leu Glu Gly Met Ala Leu Ala Lys Glu Val Leu Ser Gln Leu Lys 
                645                 650                 655     


Ala Ile Arg Asn Glu Asn Phe His Phe Thr Gln Gly Lys Arg Lys Asn 
            660                 665                 670         


Val Glu Glu Asn Ile Pro Leu Thr Lys Ala Leu Trp Glu Asn Glu Glu 
        675                 680                 685             


Lys Val Tyr Arg Gln Thr Val Lys Glu Thr Tyr Tyr Ser Asn Asn Val 
    690                 695                 700                 


Ser Met Phe Tyr Ser Gln Glu Val Ile Gln Lys Leu Val Ala Glu Leu 
705                 710                 715                 720 


Tyr Gln Asn Asn Asn Val Ala Glu Ala Gln Ile Pro Ala Phe Arg Thr 
                725                 730                 735     


Ile Trp Lys Arg Lys Asp Leu Pro Glu Tyr Ile Gly Ser Leu Asn Ile 
            740                 745                 750         


Ser Trp Asp Lys Thr Glu Pro Lys Gln Val Ile Tyr Glu Gly Ala Leu 
        755                 760                 765             


Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Lys Ser Gly 
    770                 775                 780                 


Glu Ala Lys Lys Leu Phe Phe Asp Ala Val Met Asp Asn Ala Thr Glu 
785                 790                 795                 800 


Met Glu Lys Ser Ser Asn Ala Asp Ser Arg Asn Gln Glu Lys Lys Ala 
                805                 810                 815     


Leu Ala Asn Ala Gly Lys Asn Phe Arg Asp Tyr Val Asn Gly Leu Asn 
            820                 825                 830         


Ala Ser Thr Leu Gly Glu Val Cys Gln Phe Ile Gln Asn Glu Tyr Asn 
        835                 840                 845             


Gln Gln Asn Arg Gly Lys Gln Glu Gln Glu Ile Tyr Lys His Phe Lys 
    850                 855                 860                 


Met Leu Leu Pro Ile Cys Met Arg Lys Ala Phe Gln Arg Tyr Ile Asp 
865                 870                 875                 880 


Glu Lys His Ser Phe Ile Lys Lys Pro Gly Glu Leu Pro Gln Thr Thr 
                885                 890                 895     


Glu Asp Tyr Leu Glu Asn Val Lys Val Ala Cys Pro Glu Lys Lys Ile 
            900                 905                 910         


Lys Leu Gly Arg Trp Phe Thr Phe Ala His Phe Ile His Pro Arg Glu 
        915                 920                 925             


Leu Asn Phe 
    930     


<210>  845
<211>  1234
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  845

Met Arg Ile Ile Lys Pro Tyr Gly Arg Ser Lys Thr Lys Arg Tyr Ser 
1               5                   10                  15      


Ser Gly Thr Glu Arg Arg Leu Gln Pro Asn Pro Ala Leu Arg Asp Gly 
            20                  25                  30          


Glu Ala Met Asp Ala Asp Gly Leu Ser Ile Gly Pro Phe Ala Glu Ser 
        35                  40                  45              


His Asp Ser Leu Val Ile Gly Gln Trp Ile Ser Thr Ile Asp Lys Ile 
    50                  55                  60                  


Ala Thr Lys Pro Lys Gly Lys Gly Lys Ala Thr Gln Glu Gln Arg Asn 
65                  70                  75                  80  


Val Arg Ser Ala Leu Gly Ala Ala Cys Trp Ala Arg Leu Val His Pro 
                85                  90                  95      


Asp Gly Thr Phe Gly Ala Leu Asp Ser Glu Arg Met Asn Trp Ala Arg 
            100                 105                 110         


Asn Thr Trp Glu Arg Arg Leu His Pro Tyr Ser Asp Lys Asn Phe Val 
        115                 120                 125             


Thr Asn Gly Arg Glu Lys Thr Pro Asp Ser Lys Ala His Trp Phe Asn 
    130                 135                 140                 


Arg Phe Cys Lys Gly Leu Ser Val Gln Glu Val Thr Asp Pro Ser Val 
145                 150                 155                 160 


Ala Gly Asp Val Ala Gln Ser Ile Glu Glu His Leu Thr Lys Asp Ala 
                165                 170                 175     


Phe Arg Arg Gly Gly Gly Thr Arg Arg Ser Pro Lys Ala Ser Ala Ser 
            180                 185                 190         


Arg Ala Gly Leu Ile Ala Val Arg Ala Asp Ser Ile Thr Lys Asn Ala 
        195                 200                 205             


Leu Arg Phe Pro Gly Ala Asp Ile Ala Glu Gln Arg Glu His Gly Trp 
    210                 215                 220                 


Thr Glu Glu Asp Ile Ala Arg Tyr Val Ala Lys Ser Asp Pro Val Ala 
225                 230                 235                 240 


Gln Ile Tyr Lys Ala Val Leu Asp Ala Glu Pro Asp Gly Gln Arg Val 
                245                 250                 255     


Arg Trp Ser Ile Ala Ala Glu Arg Leu Tyr Ala His Tyr Ala Arg Val 
            260                 265                 270         


Phe Thr Ala Pro Asp Ile Val Leu Asp Arg Lys Asp Ala Asp Lys Ile 
        275                 280                 285             


Leu Arg Gly Val Leu Ala Leu His Glu Ala Leu Arg Gln Leu Tyr Arg 
    290                 295                 300                 


His Arg Leu Lys Arg His Arg Arg Lys Pro Val His Val Thr Val Leu 
305                 310                 315                 320 


Leu Pro Arg Asp Ile Arg Asp Ala Leu Thr Met Ile Ser Arg Gln Gln 
                325                 330                 335     


Asp Asn Ser Asp Leu Asn Ala Leu Val Arg Leu Gly Lys Val Ile His 
            340                 345                 350         


His Glu Ala Ala Asp Gln Ala Gly Val Glu Ser Val Ala Lys Ile Ile 
        355                 360                 365             


Gly Asn Trp Pro Glu Asp Val Ser Arg Ser Tyr Tyr Trp Thr Ser Asp 
    370                 375                 380                 


Gly Gln Thr Glu Ile Lys Arg Thr Glu Ala Phe Val Arg Ala Trp Arg 
385                 390                 395                 400 


Gly Pro Ile Ala His Ala Gln Arg Thr Leu Ala Asp Trp Val Asp Pro 
                405                 410                 415     


Asp Arg Leu Ser Val Lys Ser Asp Ser Ala Glu Ala Lys Pro Pro Asp 
            420                 425                 430         


Met Leu Gly Ala Lys Phe Asp Asp Ala Leu Ala Gln Leu Asp Asp Asp 
        435                 440                 445             


Ala Ala Ile Thr Lys Ala Arg Leu Leu Phe Gly Thr Arg Ser Asp Ala 
    450                 455                 460                 


Leu Gly Gly Pro Asp Pro Lys Ala Val Leu Arg Leu Thr Lys Arg Ala 
465                 470                 475                 480 


Leu Ser Lys Leu Arg Asn Ala Ala Phe His Phe Lys Gly Met Gly Gly 
                485                 490                 495     


Phe Val Gln Asp Met Thr Leu Lys Ile Leu Pro Ser Gly Ser Glu Asp 
            500                 505                 510         


Cys Glu Val Leu Glu Arg Val His Ala Leu Trp His Ala Asp Gln Lys 
        515                 520                 525             


Asp Arg Met Ile Arg Val Lys Asp Ala Leu Val Gly Ala His Ala Glu 
    530                 535                 540                 


Val Tyr Leu Asn Gln Pro Gln Met Asn Gln Leu Trp Glu Leu Leu Gly 
545                 550                 555                 560 


Ala Gln Glu Ser Lys Ile Ala Leu Pro Arg Phe Asn Arg Val Ile Ala 
                565                 570                 575     


Arg Ala Ala His Ala Trp Thr Ser Lys Glu Asp Arg Leu Ala Leu Pro 
            580                 585                 590         


Asp Ser Ala Ser Ser Lys Asp Leu Glu Ala Gln Pro Ala Arg Arg Cys 
        595                 600                 605             


Gln Tyr Val Leu Ile Lys Met Val Tyr Glu Arg Gly Phe Arg Thr Trp 
    610                 615                 620                 


Leu Thr Ser Arg Ser Ala Asp Asp Leu Asn Ile Trp Ile Lys Gln Ala 
625                 630                 635                 640 


Thr Asp His Thr Thr Glu Ala Ala Lys Glu Phe His Lys His Gln Val 
                645                 650                 655     


Ser Lys Glu Glu Leu Ala Gln Ile Ser Ala Arg Ser Ala Gly Leu Val 
            660                 665                 670         


Lys Leu Glu Pro Gly Glu Gly Phe Ala Lys Phe Leu Phe Lys Met Thr 
        675                 680                 685             


Ala Leu Thr Thr Thr Glu Phe Arg Val Gln Lys Gly Tyr Thr His Asp 
    690                 695                 700                 


Ala Gly Arg Ala Arg Glu Gln Ala Ser Phe Leu Asp Asp Leu His Cys 
705                 710                 715                 720 


Asp Leu Val Ala Leu Ala Phe Asp Thr Tyr Leu Lys Asp Lys Lys Leu 
                725                 730                 735     


Gly Trp Leu Tyr Arg Leu Arg Gln Asp Glu Ser Pro Gly Asn Pro Gln 
            740                 745                 750         


Ser Ser Ala Ala Asp Leu Pro Leu Gly Ser Val Ala Ser Ala Gln Asp 
        755                 760                 765             


Trp Gln Ala Val Leu Tyr Leu Val Leu His Leu Ile Pro Val Asp Asp 
    770                 775                 780                 


Val Gly Arg Leu Leu His Arg Trp Arg Trp Trp Ser Asn Lys Tyr Asp 
785                 790                 795                 800 


Asp Glu His Leu Pro Ala Glu Gly Leu Gln Leu Ala Glu Ala Phe Thr 
                805                 810                 815     


Leu Tyr Leu Asp Met His Asp Ala Lys Phe Asp Gly Ala Glu Ala Ile 
            820                 825                 830         


Thr Gly Ser Ala Ala Phe His Asp Leu Phe Asp Ser Asp Thr Thr Arg 
        835                 840                 845             


Lys Gln Val Phe Pro Asp Ala Leu Ala Ala Glu Ala Glu Gly Pro Arg 
    850                 855                 860                 


Gln Ile Met Gln Arg Gly Leu Arg Glu Met Leu Arg Phe Gly Asp Met 
865                 870                 875                 880 


Ala Ser Phe Ala Pro Val Phe Ala Gly Arg Lys Val Thr Ala Glu Gln 
                885                 890                 895     


Val Lys Glu Trp Gln Asn Leu Asp Ala Gln Val Ala Ala Ala His Glu 
            900                 905                 910         


Thr Arg Lys Lys Val His Glu Asp Tyr Lys Arg Gly Leu Arg Pro Ser 
        915                 920                 925             


Thr Glu Asn Glu Arg Leu Leu Glu Gln Lys Tyr Asp Leu Ala Ala Tyr 
    930                 935                 940                 


Val Lys Ala Val Lys Thr Ile Thr Arg His Lys Arg Leu Ser His His 
945                 950                 955                 960 


Val Lys Leu Thr Asn His Val Arg Leu His Gln Ile Val Met Arg Val 
                965                 970                 975     


Leu Gly Arg Leu Val Asp Tyr Ala Gly Leu Trp Glu Arg Asp Val Tyr 
            980                 985                 990         


Phe Val Leu Leu Ala Leu Ile Cys  Leu Arg Gly Gln Thr  Pro Arg Asp 
        995                 1000                 1005             


Val Phe  Gln Asn Ala Tyr Gly  Arg Lys Ala Leu Arg  Gly Gly Gln 
    1010                 1015                 1020             


Ile Arg  Lys Ala Val Gln Asn  Leu Glu Pro Glu Tyr  Lys Thr Ala 
    1025                 1030                 1035             


Leu Glu  Arg His Phe Gly Thr  Gly Ala Phe Glu Glu  Gly Gly Val 
    1040                 1045                 1050             


Val Thr  Ile Arg Asn Asp Leu  Ala His Leu Asn Met  Met Gly Arg 
    1055                 1060                 1065             


Ala Ala  Arg Ser Asp Asp Ala  Arg Val Pro Leu Asp  Leu Thr Cys 
    1070                 1075                 1080             


Gln Ile  Asp Arg Thr Arg Arg  Leu Met Ser Tyr Asp  Arg Lys Leu 
    1085                 1090                 1095             


Gln Asn  Ser Val Ser Lys Ser  Val Thr Asp Leu Met  Glu Arg Glu 
    1100                 1105                 1110             


Lys Ile  Arg Leu Ser Phe Arg  Leu Asp Lys Gly Lys  Leu Thr Gln 
    1115                 1120                 1125             


Ala Thr  Val Lys Ala Asp Leu  Ile Lys His Phe Lys  Arg Lys Glu 
    1130                 1135                 1140             


Leu Thr  Glu Asn Leu His Asp  Pro Leu Phe Leu Gly  Met Val Ala 
    1145                 1150                 1155             


Asp Val  Tyr Gly Gly Thr Val  Gly Gln Leu Gln Asn  Asp Leu Thr 
    1160                 1165                 1170             


Asp Ala  Gln Asp Ile Ala Ala  Val Val Asn Gln Thr  Phe Ala Ala 
    1175                 1180                 1185             


Val Lys  Ala Glu Gln Asp Ala  Arg Arg Arg Pro Arg  Asn Asn Arg 
    1190                 1195                 1200             


Ala Gln  Ser Gln Asn Pro Gly  Gly Gly Thr Arg Arg  Asn Gly Gly 
    1205                 1210                 1215             


Lys Glu  Lys Tyr Gly Lys His  Pro Lys Gly Lys Arg  Thr Asp Arg 
    1220                 1225                 1230             


His 
    


<210>  846
<211>  1394
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  846

Met Arg Ile Leu Gln Ser Lys Gly Arg Ser Phe Thr Thr Phe Ser Ala 
1               5                   10                  15      


Glu Ser Ile Gly Met Thr Arg Gly Leu Glu Pro Asp Asp Thr Gln Ser 
            20                  25                  30          


Ala Ala Lys Trp Leu Asp Glu Gly Glu Lys Arg Ile Ala Pro Val Arg 
        35                  40                  45              


Ile Pro Val Phe Leu Lys Glu Asp Pro Asp Leu Ile Ile Arg Gln Val 
    50                  55                  60                  


Val Ser Val Leu Asp Lys Val Ile Arg Lys Thr Lys Ile Leu Arg Asp 
65                  70                  75                  80  


Leu Pro Leu Gln Thr Tyr Val Asp Arg Thr Leu Leu Ala Glu Glu Leu 
                85                  90                  95      


Trp Gln Arg Ile Thr Asp Arg Ile Arg Gln Ser His Asp Gly Glu Ile 
            100                 105                 110         


Thr Pro Ala Asp Leu Asp Ala Tyr Lys Ser Arg Trp Ser Trp Lys Val 
        115                 120                 125             


His Pro Tyr Ala Lys Asn Pro Pro Asp Pro Ser Asn Pro Lys Gly Asp 
    130                 135                 140                 


Gln Asn Ala Val Leu Ile Leu Lys Asn Gly Asp Arg Leu Pro Ser Pro 
145                 150                 155                 160 


Thr Asp Ser Arg Gly Arg Trp His Gly Ala Leu Trp Lys Thr Thr Ser 
                165                 170                 175     


Asp Gly Asp Pro Asp Tyr Ala Ser Thr Ala Asn Ala Ile Ile Asn His 
            180                 185                 190         


Ile Phe Ser Asn Glu Val Leu Ile Gly Gly His Tyr Leu Ser Asp Trp 
        195                 200                 205             


Ser Gly Lys Gly Ser Lys Ser Ser Val Gly Leu Ala Glu Arg Arg Gly 
    210                 215                 220                 


Asp Ser Ile Arg Ser Ser Thr Pro Asp Leu Lys Leu Pro Ile Gly Pro 
225                 230                 235                 240 


Gly Ala Ser Ala Arg Leu Leu Leu Asp Leu Asp Asp Gln Asn Ala Lys 
                245                 250                 255     


Pro Ile Ile Lys Leu Phe Phe His Gln Asp Ile Ala Ala Lys Ile Tyr 
            260                 265                 270         


Ala Phe Val Leu Glu Arg Ala Arg Val Asp Gly Pro Arg Lys Pro Asn 
        275                 280                 285             


Val Ala Phe Ser Val Arg Ser Ser Asp Phe Gly Arg Leu Leu Ser Lys 
    290                 295                 300                 


His Phe Gly Asp Val Pro Asn His Arg Asp Phe Asp Asp Glu Thr Lys 
305                 310                 315                 320 


Ile Lys Ile Val Ala Phe Tyr Asp Arg Val Lys Arg Tyr Tyr Ala Ala 
                325                 330                 335     


Leu Ser Lys Ser Glu Ser Phe Arg Arg Ala Ile Ala Lys Ala Glu Ile 
            340                 345                 350         


Ser Lys Leu Glu Ala Ile Leu Pro Arg Asp Lys Ser His Leu Leu Ala 
        355                 360                 365             


Val Leu Ala Gly Lys Glu Arg Asn Thr Glu Ile Ser Ser Leu Ile Arg 
    370                 375                 380                 


Phe Gly Lys Leu Val Gly His Ala Cys Asp Ile Ser Pro Val Val Glu 
385                 390                 395                 400 


Val Gln Thr Ala Phe Asp Asn Asn Val Arg His Leu Ala Thr Ser Asp 
                405                 410                 415     


Gly Gln Ser Glu Ile Lys Arg Asn Glu Asn Phe Thr Arg Val Trp Arg 
            420                 425                 430         


Thr Ser Val Ala Phe Ser Leu Arg Thr Leu Asp Ser Trp Leu Lys Pro 
        435                 440                 445             


Asp Trp Pro Lys Leu Thr Glu Asp Glu Ala Arg Arg Arg Asn Asp Arg 
    450                 455                 460                 


Asn Pro Gly Gly Gln Gln Ile Asn Lys Ser Ala Leu Glu Arg Asp Ile 
465                 470                 475                 480 


Ala Gln Met Arg Tyr Ile Lys Thr Ile Ala Gly Glu Glu Pro Val Glu 
                485                 490                 495     


Gly Phe Leu Asn Gly Ala Gly Ile Ile Phe Gly Ser Lys His Val Glu 
            500                 505                 510         


Phe Glu Gly Glu Ala Ala Arg Arg Cys Glu Ile Phe Ala Gln Gly Asp 
        515                 520                 525             


Lys Ala Lys Asn Arg Glu Leu Val Trp Ala Trp Leu Arg Leu Ala Ala 
    530                 535                 540                 


Glu Met Arg His Arg Thr Asn His Phe Ser Thr Lys Pro Arg Leu Val 
545                 550                 555                 560 


Ser Leu Met Gln Lys Gly Val Leu Ser Pro Thr Arg Asp Asn Pro Gly 
                565                 570                 575     


Asn Phe Glu Asn Arg Lys Gly Asn Glu Val Gln Gln Ala Ala Leu Asp 
            580                 585                 590         


Ala Phe Gly Gln Leu Leu Ser Phe Asp Ile Asn Tyr Gln Ala Ile Leu 
        595                 600                 605             


Leu Val Asn Asp Phe Asn Arg Leu Gln Val Thr Arg Tyr Thr Ser Asp 
    610                 615                 620                 


Gly Gln Phe Lys Asp Val Leu Arg Arg Ala Leu Ser Thr Asp Asp Asp 
625                 630                 635                 640 


Pro Val Ile Thr Thr Pro Lys Phe Met Ser Val Leu Arg Lys Ala Lys 
                645                 650                 655     


Gly Ile Phe Asp His Asp Leu Glu Ser Ala Pro Glu Trp Ser Lys Phe 
            660                 665                 670         


Leu Gly Ser Leu Asp Leu Thr Ala Leu Ser Ala Ala Pro Asp Gly Pro 
        675                 680                 685             


Asn Gln Phe Lys Ile Gly Leu Leu Arg His Leu Phe Ala Thr Asp Phe 
    690                 695                 700                 


Gln Ser Trp Leu Ala Arg Lys Ala Asn Thr Lys Asp Gln Ile Gln Ala 
705                 710                 715                 720 


Ala Val Val Ala Val Ser Glu Asp Lys Asn Arg Arg Thr Leu Asp Val 
                725                 730                 735     


Leu Lys Asn Glu Glu Ser Arg Val Tyr Ala Val Ala Glu Thr Ala Ala 
            740                 745                 750         


Lys Met Leu Ile Phe Ala Lys Ala Asp Ser Phe Ser Glu Leu Ala Ala 
        755                 760                 765             


Leu Val Met Ser Met Ala Phe Ala Glu Asp Asn Thr Arg Lys Ser Tyr 
    770                 775                 780                 


Lys Pro Lys Pro Glu Glu Gln Ser Lys Arg Ser Thr Trp Val Asp Asp 
785                 790                 795                 800 


Phe Gln Arg Asp Leu Phe Val Tyr Leu Phe Asn His Tyr Leu Asn Thr 
                805                 810                 815     


Gln Ser Leu His Trp Ile Phe Asp Val Thr Asp Leu Val Gly Asp Gly 
            820                 825                 830         


Glu Ala Arg Thr Val Thr Leu Phe Asp Leu Gly Ala Gly Arg Trp Ser 
        835                 840                 845             


Leu Glu Ser Lys Pro Trp His Ser Gln Phe Tyr Ala Trp Leu Tyr Leu 
    850                 855                 860                 


Thr Pro Val Asp Glu Val Ala Leu Leu Arg Asn Gln Met Arg Arg Met 
865                 870                 875                 880 


Leu Ile Leu Glu Lys Lys Gly Gly Ser Asn Glu Thr Pro Ala Leu Arg 
                885                 890                 895     


Asp Leu Asp Arg Leu Met Thr Leu Tyr Ile Ala Val Ser Ser Ala Gly 
            900                 905                 910         


Phe Asp Gly Thr Glu His Ile Gln Thr Thr Ala Glu Asp Asp Lys Arg 
        915                 920                 925             


Phe Arg Leu Tyr Gly Gly Leu Leu Tyr Glu Asp Ala Val Gln Phe Glu 
    930                 935                 940                 


Lys Val Tyr Ser Ala Ala Ala Asp Thr Asn Asp Gln Ser Leu Pro Gly 
945                 950                 955                 960 


Thr Arg Arg Gly Leu Arg Gln Ile Ala Arg Leu Gly His Ile Ser Val 
                965                 970                 975     


Leu Lys Gly Ile Phe Glu Lys His Leu Ile Thr Pro Asp Glu Val Ser 
            980                 985                 990         


Thr Leu Ile Glu Thr Lys Lys Ala  Lys Ser Phe Lys Asp  Ala Thr Lys 
        995                 1000                 1005             


Arg Ala  Lys Leu His Asn Glu  Ile Val Thr Leu Ser  Lys Gly Phe 
    1010                 1015                 1020             


Lys Pro  Asp Ile His Gln Leu  Asp Lys Lys Cys Lys  Glu Tyr Lys 
    1025                 1030                 1035             


Asp Leu  Ser Ala Glu Ile Thr  Val His Asn Phe Lys  Ala Ala Gly 
    1040                 1045                 1050             


Ala Arg  Leu Thr Glu His Ala  Arg Leu His Gln Leu  Leu Met Arg 
    1055                 1060                 1065             


Val Ile  Ser Arg Leu Ala Asp  Phe Thr Leu Ile Trp  Glu Arg Asp 
    1070                 1075                 1080             


Arg Asn  Tyr Val Leu Leu Ala  Leu Ile Tyr Pro Lys  Leu Leu His 
    1085                 1090                 1095             


Pro Asp  Glu Asn Ala Pro Arg  Leu His Arg Arg Asp  Gly Lys Val 
    1100                 1105                 1110             


Gly Phe  Leu Leu Pro Pro Glu  Thr Thr Lys Thr Met  Arg Ala Ala 
    1115                 1120                 1125             


His Ala  Pro Leu Ser Asp Asn  Asp Lys Arg Lys Leu  Ser Arg Glu 
    1130                 1135                 1140             


Ile Ala  Leu Thr Ser Glu Asn  Val Glu Glu Gly Phe  Leu Pro Leu 
    1145                 1150                 1155             


Trp Asp  Asp Asp Met Gly Tyr  Arg Leu Thr Gly Tyr  Pro Ile His 
    1160                 1165                 1170             


Leu Ala  Leu Leu Glu Met Asp  Lys Arg Asp Ala Phe  Ala Arg Phe 
    1175                 1180                 1185             


Phe Asp  Arg Ser Glu Thr Glu  Asn Pro Leu Asp Val  Ala Glu Arg 
    1190                 1195                 1200             


Ala Arg  Ile Lys Arg Gly Thr  Gly Asn Ser Ser Pro  Leu Gln Arg 
    1205                 1210                 1215             


Arg Gln  Leu Thr Phe Lys Asp  Gly Lys Arg Arg Ile  Arg Asn Asp 
    1220                 1225                 1230             


Phe Ala  His Phe Asn Val Ile  Val Ser Asp Arg Lys  Arg Val Ser 
    1235                 1240                 1245             


Leu Thr  Tyr Leu Met Asn Ala  Val Arg Ser Leu Val  Ala Tyr Asp 
    1250                 1255                 1260             


Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ala Val Ala  Asp Ile Leu 
    1265                 1270                 1275             


Val Asp  Glu Gly Leu Asp Ile  Ser Trp Glu Met Thr  Gly Asp Arg 
    1280                 1285                 1290             


Leu Arg  Asn Pro Val Val Val  Pro Arg Leu Glu Thr  Asn Leu Lys 
    1295                 1300                 1305             


Lys Val  Arg Lys His Arg Gly  Leu Ala Asp Pro Gln  Phe Val Leu 
    1310                 1315                 1320             


Pro Leu  Ala Ser Val Arg Tyr  Thr Ser Met Val Lys  Ala Leu Phe 
    1325                 1330                 1335             


Asp Phe  Gln Ala Gly Gly Tyr  Arg Lys Glu Ile Ile  Val Gly Gln 
    1340                 1345                 1350             


Glu Thr  Lys Gln Arg Gly Glu  Leu Gly Tyr Pro Val  Glu Leu Arg 
    1355                 1360                 1365             


Val Leu  Leu Gly Ser Leu Gly  Ala Asp Met Pro Asp  Asp Val Leu 
    1370                 1375                 1380             


Gly Met  Lys Leu Tyr Val Ile  Gln Pro Gln Lys 
    1385                 1390                 


<210>  847
<211>  1287
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  847

Met Arg Ile Gly Lys Val Gln Gly Arg Thr Phe Thr Gly Phe Asp Asn 
1               5                   10                  15      


Ala Arg Gly Lys Thr Leu Arg Arg Arg Leu Leu Thr Arg Pro Asp Asn 
            20                  25                  30          


Glu Ala Arg Ser Leu Ser Glu His Leu Ala His Asp Pro Lys Ala Leu 
        35                  40                  45              


Ile Gly Gln Ala Ile Ser Arg Ile Asp Thr Ile Tyr Gln Lys Pro Lys 
    50                  55                  60                  


Thr Gly Lys Pro Thr Pro Glu Gln Phe Gly His Arg Asp Thr Leu Gly 
65                  70                  75                  80  


Trp Ala Tyr Trp Lys Leu Leu Val Ala Ser Tyr Pro Glu Val Glu Gly 
                85                  90                  95      


His Arg Asp Leu Phe Val Arg Arg Leu His Pro Tyr Gly Asp Thr Pro 
            100                 105                 110         


Pro Lys Ser His Gly Gln Lys Glu Gly Glu His Gln Lys Gly Gly Lys 
        115                 120                 125             


Pro Gln Leu Glu Gly Arg Trp His Gly Val Met Ala Gln His Gly Lys 
    130                 135                 140                 


Asn Pro Asp Gln Ile Ala Ala Arg Leu Phe Asp His Leu His Asn Ser 
145                 150                 155                 160 


Glu Leu Arg Phe Gly Gly Thr Ala Ser Gly Glu Pro Arg Thr Arg Pro 
                165                 170                 175     


Gly Lys Glu Ala Thr Pro Thr Gly Leu Ile Gly Ala Arg Ala Lys Thr 
            180                 185                 190         


Ile Glu His Ser Val Leu Pro Arg Asp Ala Lys Arg Phe Val Ala Glu 
        195                 200                 205             


Trp Arg Gly Glu Asp Gln Glu Arg Tyr Ala Gly Ala Arg Asp Ile Ala 
    210                 215                 220                 


Ala Ala Ile Ser Ala Gly Leu Asn Asp Lys Asp Gln Lys Ser Gly Ser 
225                 230                 235                 240 


Gly Arg Lys Ser Ala Val Ile Gly Lys Leu Leu Ser Asp His Leu Glu 
                245                 250                 255     


Thr Leu Thr Gly Asn Arg Lys Cys Arg Phe Asp Pro Lys Ser Thr Ala 
            260                 265                 270         


Glu Thr Leu Glu Leu Arg Asp Gly Glu Ser Val Asp Asp Arg Arg Arg 
        275                 280                 285             


Ile Leu Glu Leu His Ala Glu Val Lys Ala Thr Tyr Lys Arg Met Ala 
    290                 295                 300                 


Ala Trp Lys Pro Ala Lys Leu Pro Arg Asn Ser Asp Glu Leu Phe Arg 
305                 310                 315                 320 


Leu Val Arg Gln Gln Ala Asp Asn Arg Ile Leu Asn His Leu Val Arg 
                325                 330                 335     


Val Gly Arg Ile Ser Val Tyr Ser Glu Gln Ser Asp Ala Leu Ser Glu 
            340                 345                 350         


Ser Gln Phe Trp Thr Ser Gly Gly Gln Thr Gln Ile Lys Glu Ser Glu 
        355                 360                 365             


Val Phe Ala Arg Leu Trp Ile Gly Ala Ile Ser Arg Ala Ser Tyr Ser 
    370                 375                 380                 


Met Lys Ala Trp Leu Glu Pro Glu Gly Thr Val Phe Asn Pro Ser Ile 
385                 390                 395                 400 


Asn Asp Phe Asp Val Thr Ser Ser His Asn Thr Asn Arg Ile Leu Glu 
                405                 410                 415     


Asp Ser Gly Arg Leu Ser Asn Ala Met Ala Arg Arg Ala Ile Tyr Phe 
            420                 425                 430         


Gly Glu Thr Pro Glu Phe Asp Ala Leu Gly Glu Glu Asp Gln Arg Val 
        435                 440                 445             


Leu Val Lys Lys Cys Leu Asp Ala Leu Ser Ala Cys Arg Asn Arg Thr 
    450                 455                 460                 


Phe His His Gly Gln Arg Ala Lys Phe Leu Lys Glu Val Arg Lys Gly 
465                 470                 475                 480 


Leu Lys Glu Lys Glu Ala Asp Ser Ala Gly Pro Ala Ala Trp Glu Gly 
                485                 490                 495     


Ile Arg Glu Val Ile Gln Ala Asp Ala Arg Asn Leu Gly Ala Arg Leu 
            500                 505                 510         


Leu Gln Asp Leu Thr Gly Ala Lys Val His Ser Phe Ala Thr Asp Pro 
        515                 520                 525             


Glu Phe Arg His Leu Tyr Glu Ser Val Ala Ala Thr Leu Thr Ala Gly 
    530                 535                 540                 


Gly Glu Leu Glu Ala Ala Leu Pro Arg Leu Lys Asn Val Leu Lys Arg 
545                 550                 555                 560 


Ala Glu Gly Val Arg Cys Tyr Leu Asp Thr Pro Ser Gln Arg Arg Glu 
                565                 570                 575     


Gly Asp Glu Ser Leu Ile Ala Arg Leu Pro Val Ala Pro Val Pro Arg 
            580                 585                 590         


Glu Leu Asp Asp Ala Ala Thr Lys Ala Arg His Ser Ala Leu Leu Arg 
        595                 600                 605             


Leu Tyr Asp Gly Pro Phe Arg Pro Trp Ala Thr Glu Leu Arg Gly Glu 
    610                 615                 620                 


Arg Leu Ser Asp Tyr Ala Ala Arg Ala Lys Arg Leu Ala Thr Arg Leu 
625                 630                 635                 640 


Ala Lys Ser Thr Asn Thr Ala Ser Pro Tyr Pro Asp Ser Val Glu Gly 
                645                 650                 655     


Arg Ser Val Arg Leu Arg Asp Pro Ile Thr Ala Asp Thr Ala Pro Glu 
            660                 665                 670         


Thr Leu Lys Thr Tyr Leu Ser Ala Leu Thr Ala Glu Thr Ala Thr Glu 
        675                 680                 685             


Phe Arg Val Gln Lys Gly Tyr Glu Ser Asp Gly Glu Lys Ala Lys Glu 
    690                 695                 700                 


Gln Ala Glu Phe Ile Glu Asp Phe Arg Arg Asp Met Ile Ala Leu Ala 
705                 710                 715                 720 


Phe Gln Asp Phe Ile Arg Asp His Gly Phe Ala Trp Leu Leu Asp Ile 
                725                 730                 735     


Ala Ser Lys Ala Glu Pro Ser Asn Asp Ala Pro Asn Leu Pro Asp Pro 
            740                 745                 750         


Val Asp Thr Gly Lys Asp Thr Val Phe Glu Asp Trp Gln Ala Leu Leu 
        755                 760                 765             


Tyr Leu Phe Leu His Phe Val Pro Ala Asp Asp Val Ser Gln Leu Leu 
    770                 775                 780                 


His Gln Leu Arg Lys Trp Asp Ala Leu Gln Asp Lys Tyr Glu Leu Ala 
785                 790                 795                 800 


Glu Pro Gly Glu Thr Leu Gly Gln Thr Lys Ala Asp Thr Arg Lys Ile 
                805                 810                 815     


Val Gly Gln Phe Arg Asp Cys Leu Thr Leu Phe Leu Lys Thr Gly Asp 
            820                 825                 830         


Ala Arg Phe Asp Gly Glu Gly Val Glu Leu Pro Leu Ser Asp Phe Gln 
        835                 840                 845             


Glu Leu Phe Glu Ser Pro Ala Thr Phe Lys Glu Leu Phe Leu Ala Glu 
    850                 855                 860                 


Pro Ala Glu Asn Asp Ala Ser Glu Thr Asp Asp Gln Asp Ala Pro Gly 
865                 870                 875                 880 


Glu Lys His Arg Val Thr Arg Thr Arg Arg Gly Leu Arg Gln Ile Leu 
                885                 890                 895     


Arg Tyr Asn His Met Pro Val Leu Arg Asp Leu Phe Leu Ala His Lys 
            900                 905                 910         


Val Thr Asp Ala Glu Val Asp Gly Leu Gln Ala Leu Glu Val Asp Asp 
        915                 920                 925             


Pro Gln Thr Gly Glu Ser Gln Ile Gly Ala Ala Gln Arg Ile Arg Thr 
    930                 935                 940                 


Glu Ile His His His Thr Ser Asn Asp Lys Gln Ile Ser Glu Ala Lys 
945                 950                 955                 960 


Val Glu Glu Tyr Arg Arg Ala Leu Ser Thr Ile Glu Arg His Arg Phe 
                965                 970                 975     


Leu Val Gly Arg Val Tyr Leu Gly Asp His Ile Arg Val His Lys Leu 
            980                 985                 990         


Met Met Asp Val Met Gly Arg Leu  Val Asp Phe Ala Gly  Ala Trp Glu 
        995                 1000                 1005             


Arg Glu  Ala Ala Asp Gly Asp  Arg Lys Gly Phe Ile  Ser Arg Ala 
    1010                 1015                 1020             


Ile Ala  Leu Pro Glu Val Ala  Glu Gly Tyr Ala Ala  Asp Arg Leu 
    1025                 1030                 1035             


Lys Thr  Val Ala Arg Arg Val  Leu Asp Asp Gly Glu  Ala Arg Arg 
    1040                 1045                 1050             


Ile Arg  Asn Asp Leu Gly His  Phe Asn Asp Leu Ala  Pro Thr Ser 
    1055                 1060                 1065             


Gly Pro  Ala Asn Leu Thr Phe  Val Val Asn Arg Ala  Arg Arg Met 
    1070                 1075                 1080             


Met Arg  His Asp Arg Lys Arg  Lys Asn Ala Val Thr  Lys Ser Val 
    1085                 1090                 1095             


Ile Glu  Ile Leu Asn Arg Gln  Gly Leu Gly Ile Glu  Trp Thr Met 
    1100                 1105                 1110             


Arg Asn  His Glu Leu Cys Glu  Ala Lys Leu Trp Gln  Asn Pro Val 
    1115                 1120                 1125             


Lys His  Leu Gly Phe Ala Thr  Leu Glu Gly Arg Gly  Lys Lys Trp 
    1130                 1135                 1140             


Arg Arg  Pro Phe Glu Ala Arg  Tyr Gly Asp Ala Tyr  Met Ala Met 
    1145                 1150                 1155             


Val Ala  Gln Leu Phe Asp Gly  Thr Val Thr Ser Pro  Pro Ala Lys 
    1160                 1165                 1170             


Gly Pro  Pro Gln Ser Gly Lys  Ser Gly Gly Lys Pro  Gly Lys Gly 
    1175                 1180                 1185             


Ala Glu  Gly Gly Ala Lys Glu  Lys Ser Arg Ser Pro  Thr Arg Met 
    1190                 1195                 1200             


Glu Glu  Gly Gly Val Tyr Glu  Gly Arg Val Ala Lys  Ala Lys Ser 
    1205                 1210                 1215             


Asp Lys  Gly Phe Gly Phe Leu  Leu Val Glu Gly Ala  Gln Glu Glu 
    1220                 1225                 1230             


Ile Phe  Leu His Ile Tyr Gly  Ile Ser Gly Asn Arg  Pro Ala Arg 
    1235                 1240                 1245             


Ile Glu  Asn Gly Gln Arg Tyr  Arg Phe Thr Leu Gly  Ile Asp Arg 
    1250                 1255                 1260             


Asp Arg  Glu Arg Arg Lys Glu  Arg Ala Trp Val Ala  Arg Glu Ala 
    1265                 1270                 1275             


Val Arg  Ile Asp Glu Asn Arg  Ser Lys 
    1280                 1285         


<210>  848
<211>  1217
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  848

Met Lys Ile Thr Lys Arg Lys Trp Glu Asn Ile Pro Pro Val Phe Ile 
1               5                   10                  15      


Tyr Arg Asp Val Glu Ser Gly Lys Leu Phe Thr Glu Cys Asp Arg Gln 
            20                  25                  30          


Gln Asp Tyr Thr Asp Lys Leu Phe Gln Asp Glu Cys Ser Ala Ser Asp 
        35                  40                  45              


Val Phe Lys Ile Ser Leu Gln Asn Arg Leu Phe Arg Met Gln Lys Asp 
    50                  55                  60                  


Gly Lys Thr Arg Val Lys Asn Glu Ile Thr Glu Leu Val Ala Cys Leu 
65                  70                  75                  80  


Cys Lys Asn Thr Asp Leu Arg Asn Ser Ile Asn Lys Val Lys Lys Leu 
                85                  90                  95      


Pro Leu Asn Val Ala Glu Lys Lys Cys Asn Glu Thr Leu Ser Asp Tyr 
            100                 105                 110         


Gly Lys Ser Phe Thr Ala Glu Gly Gly Thr Lys Thr Leu Phe Asn Ala 
        115                 120                 125             


Leu Leu Asp Leu Val Lys Gly Asn Asp Glu Glu Arg Ala Leu Ala Glu 
    130                 135                 140                 


Ala Glu Leu Val Lys Ile Gln Lys Ile Leu Gln Glu Glu Ile Lys His 
145                 150                 155                 160 


Arg Lys Lys Arg Ile Tyr Ser Ser Ile Arg Asn Asn Lys Ile Pro Leu 
                165                 170                 175     


Leu Ile Lys Glu Asp Gly Ser Ile Glu Ala Asn Ser Asp Arg Thr Ala 
            180                 185                 190         


Trp Leu Leu Asp Leu Leu Gln Pro Val Gln Ser Ser Leu Gln His Asp 
        195                 200                 205             


Ser Asp Asp Phe Tyr Pro Val Leu Thr Glu Met Glu Lys Ile Phe Asp 
    210                 215                 220                 


Tyr Asp Lys Leu Ser Asn Asp Ile Asn Arg Gln Leu Thr Leu Cys Asp 
225                 230                 235                 240 


Gly Lys Thr Arg Ser Ile Ala Lys Ala Ala Asp Glu Val Leu Lys Lys 
                245                 250                 255     


His Phe His Glu Leu Trp Glu Asn His Pro Asp Asn His Arg His Met 
            260                 265                 270         


Lys Tyr Tyr Phe Gln Ala Val Lys Glu Tyr Phe Lys Glu Asn Phe Pro 
        275                 280                 285             


Ile Lys Ala Lys Thr Ala Gly Ala Arg Lys Arg Gln Asp Leu Leu Thr 
    290                 295                 300                 


Asp Lys Ala Val Leu Ser Arg Leu Leu Glu Pro Lys His Met Ala Asn 
305                 310                 315                 320 


Val Val Arg Arg Lys Leu Ile Asn Gln Ser Thr Gln Met His Ile Leu 
                325                 330                 335     


Tyr Gly Lys Leu Tyr Glu Tyr Cys Cys Lys Gly Asp Lys Arg Leu Pro 
            340                 345                 350         


Val Asn Ser Asp Thr Leu Gln Arg Ile Gln Val Thr Glu Ala Val Lys 
        355                 360                 365             


Lys Gln Val Met Thr Ala Val Leu Trp Ser Ile Ser Arg Leu Cys Tyr 
    370                 375                 380                 


Phe Tyr Gln Tyr Asp Gly Asp Ile Leu Asn Asp Lys Asn Val Val Asp 
385                 390                 395                 400 


Val Lys Asp Tyr Arg Glu Asn Phe Leu Val Lys Gln Tyr Thr Thr Ala 
                405                 410                 415     


Phe Val Gln Ala Cys Lys Glu Lys Leu Gln Tyr Phe Phe Pro Leu Asp 
            420                 425                 430         


Lys Val Gln Asp Ala Tyr Asn Asp Glu Asn Val Ala Ile Leu Lys Ile 
        435                 440                 445             


Ile Arg Asp Asp Arg Gln Leu Cys Asn Lys Leu Leu Lys Glu Cys Val 
    450                 455                 460                 


Thr Cys Val Lys His Leu Arg Val Asn Ile Phe His Tyr Lys Asn Met 
465                 470                 475                 480 


Gly Phe Ala Gln Thr Leu Lys Lys Ile Ser Ala Glu Ile Glu Asn Glu 
                485                 490                 495     


Leu Asp Lys Ser Thr Ser Ile Leu Leu Trp Leu Tyr Gln Asn Asp Arg 
            500                 505                 510         


Lys Asn Leu Gly Lys Ala Phe Ala Asn Arg Ile Arg Ser Met Asn Leu 
        515                 520                 525             


Pro Leu Tyr Tyr Ser Asn Asp Leu Leu Thr Arg Ile Phe Thr Lys Gln 
    530                 535                 540                 


Gly Leu Glu Phe Ser Leu Tyr Ser Pro Asn Asn Gln Met Thr Pro Ser 
545                 550                 555                 560 


Phe Lys Arg Val Tyr Glu Arg Gly Lys Asn Leu Arg Ser Glu Tyr Glu 
                565                 570                 575     


Arg Arg Leu Ile His Glu Cys Thr Thr Lys Gly His Asp Val Lys Thr 
            580                 585                 590         


Ser Leu Glu Asn Glu Cys Glu Leu Lys Trp Phe Arg Gln Leu Lys Asn 
        595                 600                 605             


Met Thr Val Thr Ser Glu Ser Val Ile Asn Thr Asp Ile Lys Asn Asp 
    610                 615                 620                 


Ile Thr Gly Asn Ile Asp Asn Glu Ser Glu Leu Glu Met Asp Ala Phe 
625                 630                 635                 640 


Phe Glu Ser Glu Thr Tyr Ile Ser Ala Asp Ser Asp Ala Gln Arg Ala 
                645                 650                 655     


Leu Gln Asn Leu Leu Gln Leu Ile Tyr Lys His His Phe Leu Pro Glu 
            660                 665                 670         


Val Met Lys Asp Asp Thr Ile Val Thr Ser Lys Val Ser Lys Val Leu 
        675                 680                 685             


Asp Arg Asn Arg Thr Leu Ala Val Asp Arg Ser Lys Ser Asp Lys Ala 
    690                 695                 700                 


Ser Asp Phe Gly Tyr Arg Ala Val Glu Glu Ile Tyr His Asp Gly Met 
705                 710                 715                 720 


Lys Leu Ser Glu Leu Met Lys Glu Leu Gln Arg Lys Ile Ser Glu Thr 
                725                 730                 735     


Glu Lys Lys Asn Glu Glu Leu Glu Gln Asp Lys Thr Asp Tyr Ala Gln 
            740                 745                 750         


Arg Phe Val Arg Glu Leu Phe Ala Glu Ala Phe Asn Asp Phe Leu Gln 
        755                 760                 765             


Glu Arg Tyr Gly Glu Glu Tyr Tyr Asp Met Met His Pro Gln Arg Asn 
    770                 775                 780                 


Glu Arg Asp Glu Lys Glu Trp Ile Asn Glu Ser Val Asn Leu Arg Thr 
785                 790                 795                 800 


Ser Phe Asp Glu Asn Lys Ile Glu Gly Tyr Leu Leu Val Phe Tyr Thr 
                805                 810                 815     


Val Met Arg Leu Leu Asp Gly Lys Glu Leu Ser Glu Leu Gln Gln Gln 
            820                 825                 830         


Met Leu Arg Phe Arg Ala Ser Met Leu Asn Trp Thr Gly Glu Ala Asp 
        835                 840                 845             


Phe Asp Glu Asp Ile Lys Met Ile Glu Lys Ile Glu Glu Leu Ala Glu 
    850                 855                 860                 


Leu Val Arg Leu Thr Glu Ala Ala Pro Val Tyr Thr Glu Glu Val Trp 
865                 870                 875                 880 


Arg Lys Arg Ala Lys Glu Glu Phe Asn Gln Leu Ile Glu Gly Asp Met 
                885                 890                 895     


Ser Asp Tyr Gly Thr Phe Tyr Leu Gln Thr Asp Gly Ser Ser Pro Val 
            900                 905                 910         


Leu His Arg Ser Met Leu Lys Leu Met Arg Ser Gly Val Met Gly Val 
        915                 920                 925             


Tyr Arg Gln Val Leu His Asp Arg Lys Gln Ala Thr Lys His Asp Tyr 
    930                 935                 940                 


Asn Ile Tyr Cys Asp Arg His Trp Val Leu Met Asp Ser Asp Arg Arg 
945                 950                 955                 960 


Met Val Thr Phe Ala Glu Tyr Ala Gln Arg Ile Leu Gln Glu Leu His 
                965                 970                 975     


Asp Lys Tyr Ala Thr Ser Pro Lys Cys Phe Pro Gln Thr Asp His Arg 
            980                 985                 990         


Ser Tyr Gly Asn Ile Leu Gln Trp  Ile Asp Glu Tyr Asn  His Ala Lys 
        995                 1000                 1005             


Ser Asn  Leu Asn Phe Glu Thr  Leu Tyr Glu Ile Cys  Ser Ile His 
    1010                 1015                 1020             


Met Glu  Ile Leu Ser Arg Trp  Val Gly Phe Val Gln  Asp Trp Glu 
    1025                 1030                 1035             


Arg Asp  Met Tyr Phe Leu Leu  Leu Ala Trp Val Lys  Gln Gly Lys 
    1040                 1045                 1050             


Leu Tyr  Gly Ile Ser Glu Glu  Asp Ile Leu Ser Ile  Phe Glu Lys 
    1055                 1060                 1065             


Gly Lys  Ile Val Ser Lys Leu  Lys Ser Lys Leu Lys  Gly Gly Asn 
    1070                 1075                 1080             


Thr Asn  Ala Phe Phe Ser Ile  Tyr Arg Leu Asp Lys  Asp Lys Glu 
    1085                 1090                 1095             


Thr Asp  Phe Ile Arg Val Arg  Asn Asp Ile Ala His  Leu Asp Leu 
    1100                 1105                 1110             


Leu Arg  Glu Lys Gly Trp Thr  Asp Val Glu Asn Lys  Asp Cys Ser 
    1115                 1120                 1125             


Val Met  Glu Trp Tyr Ile Asn  Arg Leu Arg Ser Leu  Leu Ser Tyr 
    1130                 1135                 1140             


Asp Gln  Lys Arg Met Asn Ala  Val Thr Lys Thr Met  Gln Lys Ile 
    1145                 1150                 1155             


Phe Glu  Arg His Lys Ala Glu  Val Thr Phe Arg Val  Glu Arg Gly 
    1160                 1165                 1170             


Gly Lys  Ile Lys Phe Asp Ser  Val Asn Pro Val Met  Ile Glu His 
    1175                 1180                 1185             


Leu Lys  Glu Phe Lys Gly Ile  Ser Val Pro Ser Arg  Gly Glu Thr 
    1190                 1195                 1200             


Phe Ile  Ser Asn Leu Glu Lys  Leu Met Lys Tyr Ser  Gly Arg 
    1205                 1210                 1215         


<210>  849
<211>  1217
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  849

Met Lys Ile Thr Lys Arg Lys Trp Glu Asn Ile Pro Pro Val Phe Ile 
1               5                   10                  15      


Tyr Arg Asp Val Glu Ser Gly Lys Leu Phe Thr Glu Cys Asp Arg Gln 
            20                  25                  30          


Gln Asp Tyr Thr Asp Lys Leu Phe Gln Asp Glu Cys Ser Ala Ser Asp 
        35                  40                  45              


Val Phe Lys Ile Ser Leu Gln Asn Arg Leu Phe Arg Met Gln Lys Asp 
    50                  55                  60                  


Gly Lys Thr Arg Val Lys Asn Glu Ile Thr Glu Leu Val Ala Cys Leu 
65                  70                  75                  80  


Cys Lys Asn Thr Asp Leu Arg Asn Ser Ile Asn Lys Val Lys Lys Leu 
                85                  90                  95      


Pro Leu Asn Val Ala Glu Lys Lys Cys Asn Glu Thr Leu Ser Asp Tyr 
            100                 105                 110         


Gly Lys Ser Phe Thr Ala Glu Gly Gly Thr Lys Thr Leu Phe Asn Ala 
        115                 120                 125             


Leu Leu Asp Leu Val Lys Gly Asn Asp Glu Glu Arg Ala Leu Ala Glu 
    130                 135                 140                 


Ala Glu Leu Val Lys Ile Gln Lys Ile Leu Gln Glu Glu Ile Lys His 
145                 150                 155                 160 


Arg Lys Lys Arg Ile Tyr Ser Ser Ile Arg Asn Asn Lys Ile Pro Leu 
                165                 170                 175     


Leu Ile Lys Glu Asp Gly Ser Ile Glu Ala Asn Ser Asp Arg Thr Ala 
            180                 185                 190         


Trp Leu Leu Asp Leu Leu Gln Pro Val Gln Ser Ser Leu Gln His Asp 
        195                 200                 205             


Ser Asp Asp Phe Tyr Pro Val Leu Thr Glu Met Glu Lys Ile Phe Asp 
    210                 215                 220                 


Tyr Asp Lys Leu Ser Asn Asp Ile Asn Arg Gln Leu Thr Leu Cys Asp 
225                 230                 235                 240 


Gly Lys Thr Arg Ser Ile Ala Lys Ala Ala Asp Glu Val Leu Lys Lys 
                245                 250                 255     


His Phe His Glu Leu Trp Glu Asn His Pro Asp Asn His Arg His Met 
            260                 265                 270         


Lys Tyr Tyr Phe Gln Ala Val Lys Glu Tyr Phe Lys Glu Asn Phe Pro 
        275                 280                 285             


Ile Lys Ala Lys Thr Ala Gly Ala Arg Lys Arg Gln Asp Leu Leu Thr 
    290                 295                 300                 


Asp Lys Ala Val Leu Ser Arg Leu Leu Glu Pro Lys His Met Ala Asn 
305                 310                 315                 320 


Val Val Arg Arg Lys Leu Ile Asn Gln Ser Thr Gln Met His Ile Leu 
                325                 330                 335     


Tyr Gly Lys Leu Tyr Glu Tyr Cys Cys Lys Gly Asp Lys Arg Leu Pro 
            340                 345                 350         


Val Asn Ser Asp Thr Leu Gln Arg Ile Gln Val Thr Glu Ala Val Lys 
        355                 360                 365             


Lys Gln Val Met Thr Ala Val Leu Trp Ser Ile Ser Arg Leu Cys Tyr 
    370                 375                 380                 


Phe Tyr Gln Tyr Asp Gly Asp Ile Leu Asn Asp Lys Asn Val Val Asp 
385                 390                 395                 400 


Val Lys Asp Tyr Arg Glu Asn Phe Leu Val Lys Gln Tyr Thr Thr Ala 
                405                 410                 415     


Phe Val Gln Ala Cys Lys Glu Lys Leu Gln Tyr Phe Phe Pro Leu Asp 
            420                 425                 430         


Lys Val Gln Asp Ala Tyr Asn Asp Glu Asn Val Ala Ile Leu Lys Ile 
        435                 440                 445             


Ile Arg Asp Asp Arg Gln Leu Cys Asn Lys Leu Leu Lys Glu Cys Val 
    450                 455                 460                 


Thr Cys Val Lys His Leu Arg Val Asn Ile Phe His Tyr Lys Asn Met 
465                 470                 475                 480 


Gly Phe Ala Gln Thr Leu Lys Lys Ile Ser Ala Glu Ile Glu Asn Glu 
                485                 490                 495     


Leu Asp Lys Ser Thr Ser Ile Leu Leu Trp Leu Tyr Gln Asn Asp Arg 
            500                 505                 510         


Lys Asn Leu Gly Lys Ala Phe Ala Asn Arg Ile Arg Ser Met Asn Leu 
        515                 520                 525             


Pro Leu Tyr Tyr Ser Asn Asp Leu Leu Thr Arg Ile Phe Thr Lys Gln 
    530                 535                 540                 


Gly Leu Glu Phe Ser Leu Tyr Ser Pro Asn Asn Gln Met Thr Pro Ser 
545                 550                 555                 560 


Phe Lys Arg Val Tyr Glu Arg Gly Lys Asn Leu Arg Ser Glu Tyr Glu 
                565                 570                 575     


Arg Arg Leu Ile His Glu Cys Thr Thr Lys Gly His Asp Val Lys Thr 
            580                 585                 590         


Ser Leu Glu Asn Glu Cys Glu Leu Lys Trp Phe Arg Gln Leu Lys Asn 
        595                 600                 605             


Met Thr Val Thr Ser Glu Ser Val Ile Asn Thr Asp Ile Lys Asn Asp 
    610                 615                 620                 


Ile Thr Gly Asn Ile Asp Asn Glu Ser Glu Leu Glu Met Asp Ala Phe 
625                 630                 635                 640 


Phe Glu Ser Glu Thr Tyr Ile Ser Ala Asp Ser Asp Ala Gln Arg Ala 
                645                 650                 655     


Leu Gln Asn Leu Leu Gln Leu Ile Tyr Lys His His Phe Leu Pro Glu 
            660                 665                 670         


Val Met Lys Asp Asp Thr Ile Val Thr Ser Lys Val Ser Lys Val Leu 
        675                 680                 685             


Asp Arg Asn Arg Thr Leu Ala Val Asp Arg Ser Lys Ser Asp Lys Ala 
    690                 695                 700                 


Ser Asp Phe Gly Tyr Arg Ala Val Glu Glu Ile Tyr His Asp Gly Met 
705                 710                 715                 720 


Lys Leu Ser Glu Leu Met Lys Glu Leu Gln Arg Lys Ile Ser Glu Thr 
                725                 730                 735     


Glu Lys Lys Asn Glu Glu Leu Glu Gln Asp Lys Thr Asp Tyr Ala Gln 
            740                 745                 750         


Arg Phe Val Arg Glu Leu Phe Ala Glu Ala Phe Asn Asp Phe Leu Gln 
        755                 760                 765             


Glu Arg Tyr Gly Glu Glu Tyr Tyr Asp Met Met His Pro Gln Arg Asn 
    770                 775                 780                 


Glu Arg Asp Glu Lys Glu Trp Ile Asn Glu Ser Val Asn Leu Arg Thr 
785                 790                 795                 800 


Ser Phe Asp Glu Asn Lys Ile Glu Gly Tyr Leu Leu Val Phe Tyr Thr 
                805                 810                 815     


Val Met Arg Leu Leu Asp Gly Lys Glu Leu Ser Glu Leu Gln Gln Gln 
            820                 825                 830         


Met Leu Arg Phe Arg Ala Ser Met Leu Asn Trp Thr Gly Glu Ala Asp 
        835                 840                 845             


Phe Asp Glu Asp Ile Lys Met Ile Glu Lys Ile Glu Glu Leu Ala Glu 
    850                 855                 860                 


Leu Val Arg Leu Thr Glu Ala Ala Pro Val Tyr Thr Glu Glu Val Trp 
865                 870                 875                 880 


Arg Lys Arg Ala Lys Glu Glu Phe Asn Gln Leu Ile Glu Gly Asp Met 
                885                 890                 895     


Ser Asp Tyr Gly Thr Phe Tyr Leu Gln Thr Asp Gly Ser Ser Pro Val 
            900                 905                 910         


Leu His Arg Ser Met Leu Lys Leu Met Arg Ser Gly Val Met Gly Val 
        915                 920                 925             


Tyr Arg Gln Val Leu His Asp Arg Lys Gln Ala Thr Lys His Asp Tyr 
    930                 935                 940                 


Asn Ile Tyr Cys Asp Arg His Trp Val Leu Met Asp Ser Asp Arg Arg 
945                 950                 955                 960 


Met Val Thr Phe Ala Glu Tyr Ala Gln Arg Ile Leu Gln Glu Leu His 
                965                 970                 975     


Asp Lys Tyr Ala Thr Ser Pro Lys Cys Phe Pro Gln Thr Asp His Arg 
            980                 985                 990         


Ser Tyr Gly Asn Ile Leu Gln Trp  Ile Asp Glu Tyr Asn  His Ala Lys 
        995                 1000                 1005             


Ser Asn  Leu Asn Phe Glu Thr  Leu Tyr Glu Ile Cys  Ser Ile His 
    1010                 1015                 1020             


Met Glu  Ile Leu Ser Arg Trp  Val Gly Phe Val Gln  Asp Trp Glu 
    1025                 1030                 1035             


Arg Asp  Met Tyr Phe Leu Leu  Leu Ala Trp Val Lys  Gln Gly Lys 
    1040                 1045                 1050             


Leu Tyr  Gly Ile Ser Glu Glu  Asp Ile Leu Ser Ile  Phe Glu Lys 
    1055                 1060                 1065             


Gly Lys  Ile Val Ser Lys Leu  Lys Ser Lys Leu Lys  Gly Gly Asn 
    1070                 1075                 1080             


Thr Asn  Ala Phe Phe Ser Ile  Tyr Arg Leu Asp Lys  Asp Lys Glu 
    1085                 1090                 1095             


Thr Asp  Phe Ile Arg Val Arg  Asn Asp Ile Ala His  Leu Asp Leu 
    1100                 1105                 1110             


Leu Arg  Glu Lys Gly Trp Thr  Asp Val Glu Asn Lys  Asp Cys Ser 
    1115                 1120                 1125             


Val Met  Glu Trp Tyr Ile Asn  Arg Leu Arg Ser Leu  Leu Ser Tyr 
    1130                 1135                 1140             


Asp Gln  Lys Arg Met Asn Ala  Val Thr Lys Thr Met  Gln Lys Ile 
    1145                 1150                 1155             


Phe Glu  Arg His Lys Ala Glu  Val Thr Phe Arg Val  Glu Arg Gly 
    1160                 1165                 1170             


Gly Lys  Ile Lys Phe Asp Ser  Val Asn Pro Val Met  Ile Glu His 
    1175                 1180                 1185             


Leu Lys  Glu Phe Lys Gly Ile  Ser Val Pro Ser Arg  Gly Glu Thr 
    1190                 1195                 1200             


Phe Ile  Ser Asn Leu Glu Lys  Leu Met Lys Tyr Ser  Gly Arg 
    1205                 1210                 1215         


<210>  850
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  850

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  851
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  851

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Asp Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Asn Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His 
            180                 185                 190         


Glu Arg Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Leu 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Lys Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Arg Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Asp Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Ile Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  852
<211>  1102
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  852

Met Arg Val Ser Lys Val Lys Val Asp Asn Lys Asn Met Val Leu Met 
1               5                   10                  15      


Arg Arg Thr Thr Gly Asn Gly Ala Leu Val Tyr Glu Gly Glu Thr Ser 
            20                  25                  30          


Asn Arg Thr Ile Glu Ile Leu Pro Lys Gln Lys Ile Gln Ser Phe Ser 
        35                  40                  45              


Leu Ser Ile Glu Asn Lys Thr Leu Ile Lys Arg Asp Ser Leu Lys Gly 
    50                  55                  60                  


Thr Val Gln Lys Asn Lys Tyr Asp Val Ile Arg Ala Ile Ile Lys Tyr 
65                  70                  75                  80  


Asn Arg Phe Pro Asp Arg Ile Ser Ala Glu Glu Val Leu Pro Phe Leu 
                85                  90                  95      


Asn His Lys Phe Gln Asn Glu Ile Lys Tyr Tyr Asn Asp Asn Lys Leu 
            100                 105                 110         


His Ser Phe Leu Leu Thr Ser Leu Ile Val Glu Ala Val Lys Glu Lys 
        115                 120                 125             


Asn Pro Gln Lys Leu Gln Pro Tyr Phe Asp Trp Glu Glu Trp Tyr Ile 
    130                 135                 140                 


Ser Asn Lys Ser Asn Ala Leu Ile Lys Ser Ile Glu Asn Asn Lys Ile 
145                 150                 155                 160 


Asp Ser Glu Lys Lys Asp Ser Lys Arg Lys Lys Thr Leu Gln Thr Trp 
                165                 170                 175     


Ala Ala Glu Tyr Thr Asp Asn Gly Ser Ile Asp Leu Ser Glu Tyr His 
            180                 185                 190         


Asn Ile Tyr Asp Ile Asp Thr Leu Val Arg Ala Leu Ile Lys Ala Asp 
        195                 200                 205             


Lys Gly Glu Leu Lys Glu Asp Gly Thr Pro Lys Asn Ala Asn Ala Phe 
    210                 215                 220                 


His Arg Asn Leu Lys Arg Thr Leu Gln Asp His Gln Lys Thr Val Phe 
225                 230                 235                 240 


Gly Thr Arg Glu Ala Ser Asn Met Thr Asn Arg Glu Asn Asp Gln Leu 
                245                 250                 255     


Ala Val Tyr His Leu Glu Val Val Lys Tyr Leu Glu His Tyr Phe Ser 
            260                 265                 270         


Val Lys Ser Thr Gln Arg Arg Asn Thr Arg Ala Asp Ile Asp Tyr Tyr 
        275                 280                 285             


Leu Lys Ala Glu Thr Ile Lys Asn Ile Ile Thr Lys Gln Leu Leu Asn 
    290                 295                 300                 


Ala Val Arg Asn Tyr Leu Leu Gln Gln Gly Lys Ala Gln His His Lys 
305                 310                 315                 320 


Phe Ala Glu Ile Lys Pro Asp Ser Asn Ser Leu Thr Glu Ile Lys Arg 
                325                 330                 335     


Asn Glu Ala Phe Val Leu Asn Met Ile Asp Ala Cys Gly Phe Ala Ala 
            340                 345                 350         


Asn Asn Ile Arg Asn Ile Val Asp Ala Glu Gln Ile Asn Asp Ile Leu 
        355                 360                 365             


Ser Lys Lys Glu Tyr Val Gln Ser Leu Asp Ser Asn Arg Val Asn Asn 
    370                 375                 380                 


Gln Leu Phe Lys Phe Phe Phe Gly Thr Asp Leu Pro Glu Thr Ala Thr 
385                 390                 395                 400 


Asp Lys Val Lys Thr Leu Trp Ala Met Arg Gly Ala Val Gln Gln Ile 
                405                 410                 415     


Arg Asn Lys Val Val His Tyr Lys Gln Lys Ala Leu Asp Ala Ile Phe 
            420                 425                 430         


Asn Val Thr Asp Phe Glu Tyr Pro Ser Phe Asn Asn Ser Ile Tyr Thr 
        435                 440                 445             


Asp Thr Ile Tyr Lys Asp Cys Leu Glu Thr Glu Leu Gln Lys Leu Pro 
    450                 455                 460                 


Glu Ala Phe Ala Gln Gln Leu Lys Thr Gly Gly Ala Leu Thr Tyr Tyr 
465                 470                 475                 480 


Pro Phe Asp Asp Leu Lys Thr Leu Leu Asn Lys Val Ala Phe Ser Leu 
                485                 490                 495     


Cys Arg Ser Val Val Pro Phe Ala Pro Gly Phe Lys Lys Val Gln Lys 
            500                 505                 510         


Gln Gly Gln Asn Tyr Gln Asn Ala His Lys Glu Asn Phe Tyr Asn Leu 
        515                 520                 525             


Asp Leu Lys Ser Tyr Leu Pro Lys Glu Lys Phe Asp Glu Glu Ala Tyr 
    530                 535                 540                 


Asn Ala Arg Tyr Phe Leu Leu Lys Leu Ile Tyr Asn Asn Leu Phe Leu 
545                 550                 555                 560 


Ser Asp Phe Thr Gly Asn Arg Glu Gln Phe Ser Ala Thr Val Asn Tyr 
                565                 570                 575     


Ile Leu Lys Arg Asn Lys Lys Gln Ala Glu Asn Ser Arg Arg Pro Lys 
            580                 585                 590         


Ala Tyr Ala Phe Glu Ala Val Arg Gln Met Lys Lys Glu Glu Ser Ile 
        595                 600                 605             


Thr Ser Tyr Met Ala Tyr Ala Gln Asn Gln Leu Met Val Glu Lys Asn 
    610                 615                 620                 


Lys Lys Glu Asp Asp Lys Pro Glu Asp Ile Arg Ile Asn Phe Glu Lys 
625                 630                 635                 640 


Phe Val Leu Gln Val Phe Ile Lys Gly Phe Asp Asp Phe Leu Leu Asn 
                645                 650                 655     


Glu Lys Phe Lys Phe Ile Ala Thr Pro Cys Phe Gln Leu Ser Lys Glu 
            660                 665                 670         


Asn Thr Lys Gln Gln Gln Ala Asp Val Leu Asn Gln Phe Glu Gln Arg 
        675                 680                 685             


Ile Ile Lys Glu Cys Arg Phe Gln Ser His Thr Ile Lys Ala Glu Glu 
    690                 695                 700                 


Ala Lys His Val Ala Phe Phe Thr Phe Cys Lys Leu Leu Asp Ala Thr 
705                 710                 715                 720 


His Leu Ser Asn Leu Arg Asn Glu Leu Ile Lys Phe Lys Gln Ser Ser 
                725                 730                 735     


Lys Gln Phe Glu Leu Cys His Val Leu Glu Ile Ile Glu Leu Ser Leu 
            740                 745                 750         


Leu Asn Ala Asp Val Val Pro Ala Asp Tyr Arg Glu Leu Tyr Ala Asn 
        755                 760                 765             


Lys Val Thr Cys Leu Asn Arg Val Arg Pro Phe Ile Ala Asp Gly Val 
    770                 775                 780                 


Asp Ile Thr Lys Trp Ser Gly Leu Phe Ile Gln Thr Asp Asn Glu Thr 
785                 790                 795                 800 


Pro Val Ile His Ala Asn Val Glu Leu Thr Val Lys Tyr Gly Thr Thr 
                805                 810                 815     


Lys Leu Leu Glu Gln Leu Ile Ala Lys Gly Ala Ser Phe Lys Leu Ser 
            820                 825                 830         


Glu Ser Asp Phe Asn Leu Trp Asn Ser Ala Lys Asp Thr Ile Lys Glu 
        835                 840                 845             


Val Ile Asn Lys Arg Leu Ser Leu His Lys Gln Trp Glu Asp Ala Ile 
    850                 855                 860                 


Arg Lys Asp Lys Glu Glu Lys Asn Lys Arg Val Lys Thr Arg Ser Asn 
865                 870                 875                 880 


Phe Ala Gln Gln Phe Ile Asn Lys Glu Arg Asp Ser Tyr Phe Asp Leu 
                885                 890                 895     


Cys Asp Tyr Ile Asp Ala Tyr Asn Trp Tyr Asp Ser Lys Leu His Phe 
            900                 905                 910         


Val Asn Leu Ile Arg Leu His His Leu Thr Ile Asp Ile Leu Gly Arg 
        915                 920                 925             


Met Val Gly Phe Val Ala Ile Trp Glu Arg Asp Phe Gln Tyr Met Thr 
    930                 935                 940                 


Glu Ser Ile Ser Pro Met Asn Ser Ser Lys Glu Leu Asp Phe Thr Lys 
945                 950                 955                 960 


Gly Phe Pro Leu Leu Lys Gly Ile Gln Leu Asp Tyr Tyr Lys Arg Ile 
                965                 970                 975     


Phe Leu Ser Gly Asn Tyr Arg Asp Ile Arg Asn Tyr Ile Ala His Phe 
            980                 985                 990         


Asn Tyr Leu Thr Asp Ser Lys Phe  Ser Met Ile Asp Leu  Ile Asn Glu 
        995                 1000                 1005             


Leu Arg  Glu Leu Leu Ser Tyr  Asp Arg Lys Leu Lys  Asn Ala Val 
    1010                 1015                 1020             


Asn Lys  Ala Phe Ile Asp Leu  Phe Asp Lys Gln Gly  Met Val Leu 
    1025                 1030                 1035             


Lys Leu  Lys Leu Asn Asp Ala  His Arg Phe Glu Ile  Glu Ser Val 
    1040                 1045                 1050             


Glu Pro  Lys Leu Leu Tyr His  Leu Gly Thr Thr Pro  Ala Arg Asp 
    1055                 1060                 1065             


Pro Ile  Ser Thr Tyr Gln Val  Lys Pro Gln Tyr Cys  Asp Met Cys 
    1070                 1075                 1080             


Lys Ala  Leu Leu Glu Ile Lys  Asn Ser Ser Arg Leu  Asn Asn Val 
    1085                 1090                 1095             


Ile Ile  Ser Leu 
    1100         


<210>  853
<211>  1193
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  853

Met Lys Gly Gly Ser Met Lys Ile Thr Lys Val Asp Gly Leu Ser His 
1               5                   10                  15      


Tyr Lys Lys Gln Asp Lys Gly Val Leu Lys Lys Lys Trp Glu Asn Leu 
            20                  25                  30          


Asp Glu Arg Lys Glu Arg Glu Lys Ile Glu Glu Arg Tyr Asn Lys Gln 
        35                  40                  45              


Ile Glu Ser Lys Ile Tyr Lys Glu Phe Phe Arg Leu Lys Asp Gly Lys 
    50                  55                  60                  


Arg Ile Thr Lys Glu Glu Lys Asp Gln Asn Ile Lys Ser Leu Tyr Phe 
65                  70                  75                  80  


Phe Ile Glu Glu Leu Tyr Leu Ser Lys Glu Asn Glu Glu Trp Glu Leu 
                85                  90                  95      


Glu Asn Ile Asn Leu Glu Ile Leu Asp Asp Lys Glu Arg Val Ile Lys 
            100                 105                 110         


Gly Tyr Lys Phe Lys Glu Asp Val Tyr Phe Phe Lys Glu Gly Asp Lys 
        115                 120                 125             


Glu Tyr Tyr Leu Arg Thr Leu Phe Asn Asn Leu Ile Glu Lys Ile Gln 
    130                 135                 140                 


Asn Glu Asn Arg Glu Lys Val Arg Lys Ser Lys Glu Phe Ser Asp Leu 
145                 150                 155                 160 


Lys Glu Ile Phe Lys Lys Tyr Arg Asp Arg Lys Ile Asp Leu Leu Leu 
                165                 170                 175     


Lys Ser Ile Asn Asn Asn Lys Ile Asn Leu Glu Tyr Lys Lys Glu Asn 
            180                 185                 190         


Val Asn Glu Glu Ile Tyr Gly Ile Asn Pro Thr Asn Asp Arg Glu Met 
        195                 200                 205             


Thr Phe Tyr Glu Leu Leu Lys Glu Ile Ile Glu Lys Lys Asp Glu Gln 
    210                 215                 220                 


Lys Ser Ile Leu Glu Glu Lys Leu Asp Asn Phe Asp Ile Thr Asn Phe 
225                 230                 235                 240 


Leu Glu Asn Ile Glu Lys Ile Phe Asn Glu Glu Thr Glu Ile Asn Ile 
                245                 250                 255     


Ile Lys Gly Lys Val Leu Asn Glu Leu Arg Glu Tyr Ile Lys Glu Lys 
            260                 265                 270         


Glu Glu Asn Asn Ser Asp Tyr Arg Leu Lys Gln Ile Tyr Asn Leu Glu 
        275                 280                 285             


Leu Lys Lys Tyr Ile Glu Asn Asn Phe Ser Tyr Lys Lys Gln Lys Ser 
    290                 295                 300                 


Lys Ser Lys Asn Gly Lys Asn Asp Tyr Leu Tyr Leu Asn Phe Leu Lys 
305                 310                 315                 320 


Lys Ile Met Phe Ile Glu Glu Val Asp Glu Lys Lys Gly Ile Asn Lys 
                325                 330                 335     


Glu Lys Phe Lys Asn Lys Ile Asn Ser Asn Phe Lys Asn Leu Phe Val 
            340                 345                 350         


Gln His Ile Leu Asp Tyr Gly Lys Leu Leu Tyr Tyr Lys Glu Asn Asp 
        355                 360                 365             


Glu Tyr Ile Lys Asn Thr Gly Gln Leu Glu Thr Lys Asp Leu Glu Tyr 
    370                 375                 380                 


Ile Lys Thr Lys Glu Thr Leu Ile Arg Lys Met Ala Val Leu Val Ser 
385                 390                 395                 400 


Phe Ala Ala Asn Ser Tyr Tyr Asn Leu Phe Gly Ser Val Ser Glu Asp 
                405                 410                 415     


Ile Leu Gly Thr Glu Val Val Lys Asn Arg Arg Thr Asn Val Ile Lys 
            420                 425                 430         


Val Lys Ser Tyr Ile Phe Lys Glu Lys Met Leu Asn Tyr Phe Phe Asp 
        435                 440                 445             


Ser Glu Asp Phe Asp Val Asn Lys Thr Ile Glu Val Leu Glu Ser Ile 
    450                 455                 460                 


Ser Tyr Ser Ile Tyr Asn Ile Arg Asn Gly Val Gly His Phe Asn Lys 
465                 470                 475                 480 


Leu Val Leu Gly Lys Tyr Lys Lys Lys Asp Ile Thr Thr Asn Lys Arg 
                485                 490                 495     


Val Glu Glu Asp Leu Asn Asn Asn Glu Glu Ile Lys Gly Tyr Phe Ile 
            500                 505                 510         


Lys Lys Arg Gly Glu Ile Glu Lys Lys Ile Lys Glu Arg Phe Leu Ser 
        515                 520                 525             


Asn Asn Leu Gln Tyr Tyr Tyr Ala Lys Glu Lys Ile Glu Asn Tyr Phe 
    530                 535                 540                 


Lys Val Tyr Glu Phe Glu Ile Leu Lys Glu Lys Ile Pro Phe Ala Pro 
545                 550                 555                 560 


Asn Phe Lys Arg Ile Ile Lys Lys Gly Glu Asp Leu Phe Asn Asn Lys 
                565                 570                 575     


Lys Asn Lys Lys Tyr Glu Tyr Phe Lys Asn Phe Asp Lys Asn Ser Ala 
            580                 585                 590         


Glu Glu Lys Lys Glu Phe Leu Lys Thr Arg Asn Phe Leu Leu Lys Glu 
        595                 600                 605             


Leu Tyr Tyr Asn Asn Phe Tyr Lys Glu Phe Phe Ser Glu Arg Lys Lys 
    610                 615                 620                 


Tyr Glu Phe Lys Lys Ile Ile Thr Glu Val Lys Glu Glu Lys Lys Asn 
625                 630                 635                 640 


Arg Gly Asn Thr Asn Ser Lys Lys Ser Gly Val Ser Phe Gln Ser Ile 
                645                 650                 655     


Asp Asp Tyr Asn Thr Lys Ile Ser Ile Ser Asp Tyr Ile Ala Ser Ile 
            660                 665                 670         


His Lys Lys Glu Met Glu Arg Val Glu Lys Tyr Asn Glu Glu Lys Gln 
        675                 680                 685             


Lys Asp Thr Ala Lys Tyr Ile Arg Asp Phe Val Glu Glu Ile Phe Leu 
    690                 695                 700                 


Thr Gly Phe Ile Asn Tyr Leu Glu Lys Asp Glu Arg Leu His Phe Leu 
705                 710                 715                 720 


Lys Glu Glu Phe Ser Val Leu Cys Asn Ser Asn Asn Asn Val Ile Asp 
                725                 730                 735     


Phe Asn Val Asn Ile Asn Glu Glu Lys Ile Lys Glu Phe Leu Lys Glu 
            740                 745                 750         


Asn Asp Ser Lys Thr Leu Asn Leu Tyr Leu Phe Phe Asn Met Ile Asp 
        755                 760                 765             


Ser Lys Arg Ile Ser Glu Phe Arg Asn Glu Leu Ile Lys Tyr Lys Gln 
    770                 775                 780                 


Phe Thr Lys Lys Arg Leu Asp Glu Glu Lys Glu Phe Leu Gly Ile Lys 
785                 790                 795                 800 


Ile Glu Leu Tyr Glu Thr Leu Ile Glu Phe Val Ile Leu Thr Arg Glu 
                805                 810                 815     


Lys Leu Asp Thr Lys Lys Ser Glu Glu Thr Asp Ala Trp Leu Val Asp 
            820                 825                 830         


Lys Leu Tyr Val Lys Glu Lys Asn Glu Cys Asn Glu Tyr Glu Tyr Lys 
        835                 840                 845             


Glu Tyr Glu Glu Ile Leu Lys Leu Phe Val Asp Glu Lys Ile Leu Ser 
    850                 855                 860                 


Leu Lys Glu Ala Pro Tyr Tyr Ala Thr Asp Asn Lys Thr Pro Ile Ile 
865                 870                 875                 880 


Leu Ser Asn Phe Glu Lys Thr Arg Lys Tyr Gly Thr Gln Ser Leu Leu 
                885                 890                 895     


Ser Glu Ile Gln Ser Asn Tyr Lys Tyr Ser Lys Val Glu Lys Glu Asn 
            900                 905                 910         


Ile Glu Asp Tyr Asp Lys Lys Glu Glu Ile Glu Lys Lys Lys Lys Ser 
        915                 920                 925             


Asn Ile Glu Lys Leu Gln Asp Leu Lys Val Glu Leu His Lys Lys Trp 
    930                 935                 940                 


Glu Gln Asn Lys Ile Thr Glu Lys Glu Ile Lys Lys Tyr Asn Asp Thr 
945                 950                 955                 960 


Ile Lys Glu Ile Arg Glu Tyr Asn Tyr Leu Lys Asn Lys Glu Glu Leu 
                965                 970                 975     


Gln Asn Val Tyr Leu Leu His Glu Ile Leu Ser Asp Leu Leu Ala Arg 
            980                 985                 990         


Asn Val Ala Phe Phe Asn Lys Trp  Glu Arg Asp Phe Lys  Phe Ile Val 
        995                 1000                 1005             


Ile Ala  Ile Lys Gln Phe Leu  Arg Glu Asn Asp Lys  Glu Lys Val 
    1010                 1015                 1020             


Glu Asn  Phe Leu Asn Pro Pro  Asp Asn Ser Lys Gly  Lys Lys Val 
    1025                 1030                 1035             


Tyr Phe  Ser Val Ser Lys Tyr  Lys Asn Thr Val Glu  Asn Ile Asp 
    1040                 1045                 1050             


Gly Ile  His Lys Asn Phe Met  Asn Leu Ile Phe Leu  Asn Asn Lys 
    1055                 1060                 1065             


Phe Met  Asn Arg Lys Ile Asp  Lys Met Asn Cys Thr  Ile Trp Val 
    1070                 1075                 1080             


Tyr Phe  Arg Asn Tyr Ile Ala  His Phe Leu His Leu  His Thr Lys 
    1085                 1090                 1095             


Asn Glu  Lys Ile Ser Leu Ile  Asn Gln Met Asn Leu  Leu Ile Lys 
    1100                 1105                 1110             


Leu Phe  Ser Tyr Asp Lys Lys  Val Gln Asn His Ile  Leu Lys Ser 
    1115                 1120                 1125             


Thr Lys  Thr Leu Leu Glu Lys  Tyr Asn Ile Gln Ile  Asn Phe Glu 
    1130                 1135                 1140             


Ile Ser  Asn Asp Lys Asn Glu  Val Phe Lys Tyr Lys  Ile Lys Asn 
    1145                 1150                 1155             


Arg Leu  Tyr Ser Lys Lys Gly  Lys Met Leu Gly Lys  Asn Asn Lys 
    1160                 1165                 1170             


Phe Glu  Ile Leu Glu Asn Glu  Phe Leu Glu Asn Val  Lys Thr Leu 
    1175                 1180                 1185             


Leu Glu  Tyr Ser Lys 
    1190             


<210>  854
<211>  904
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  854

Met Lys Val Thr Lys Ile Asp Gly Ile Ser His Lys Lys Tyr Lys Glu 
1               5                   10                  15      


Lys Gly Lys Leu Ile Lys Ser Asn Glu Ile Glu Lys Asp Val Thr Glu 
            20                  25                  30          


Glu Arg Phe Asn Asn Ile Glu Ala Lys Thr Thr Glu Leu Phe Gln Lys 
        35                  40                  45              


Thr Leu Asp Phe Tyr Val Lys Asn Tyr Glu Lys Cys Glu Glu Gln Asn 
    50                  55                  60                  


Lys Glu Arg Arg Glu Lys Ala Lys Asn Tyr Phe Ser Lys Val Lys Leu 
65                  70                  75                  80  


Ile Val Asp Asn Lys Lys Ile Thr Ile Cys Asn Glu Asn Thr Glu Lys 
                85                  90                  95      


Ile Glu Ile Glu Asp Phe Asn Glu Tyr Asp Val Arg Asn Arg Lys Tyr 
            100                 105                 110         


Phe Asn Ile Leu Asn Lys Ile Leu Asn Gly Glu Asn Cys Thr Glu Glu 
        115                 120                 125             


Asp Leu Glu Val Phe Glu Asn Asp Leu Gln Lys Lys Leu Asn Gln Ile 
    130                 135                 140                 


Gln Ser Ile Lys Asn Ser Leu Glu Lys Asn Lys Ala His Phe Lys Lys 
145                 150                 155                 160 


Glu Ser Val Asn Asn Thr Ala Asp Arg Val Lys Gly Asn Asn Lys Lys 
                165                 170                 175     


Ser Leu Phe Tyr Glu Tyr Tyr Arg Asn Ser Ser Lys His Gln Glu Tyr 
            180                 185                 190         


Val Asn Asn Ile Phe Glu Ala Phe Asp Lys Leu Tyr Ser Asn Ser His 
        195                 200                 205             


Glu Asp Ile Asn Asn Leu Phe Leu Glu Ile Thr Lys Asp Ser Asn Asp 
    210                 215                 220                 


Arg Asn Ile Arg Lys Ile Arg Glu Ala Tyr His Glu Ile Leu Asn Lys 
225                 230                 235                 240 


Asn Lys Thr Glu Phe Gly Glu Glu Leu Tyr Lys Lys Ile Gln Asp Asn 
                245                 250                 255     


Ile Ser Asn Phe Asp Lys Leu Leu Glu Ile Glu Pro Glu Ile Lys Glu 
            260                 265                 270         


Leu Thr Lys Ser Gln Ile Phe Tyr Lys Tyr Tyr Ile Asp Lys Val Tyr 
        275                 280                 285             


Leu Asp Glu Thr Ser Thr Lys His Cys Phe Cys His Leu Val Glu Ile 
    290                 295                 300                 


Glu Val Ser Gln Leu Leu Lys Asn Tyr Val Tyr Ser Lys Lys Asp Ile 
305                 310                 315                 320 


Asn Lys Glu Lys Leu Glu Asn Ile Phe Glu Tyr Cys Lys Leu Lys Asn 
                325                 330                 335     


Leu Val Lys Asn Lys Leu Val Asn Lys Leu Asn Asn Tyr Ile Arg Asn 
            340                 345                 350         


Cys Gly Lys Tyr Asn Gly Tyr Ile Asn Asn Asn Asp Val Ile Asn Ser 
        355                 360                 365             


Glu Lys Ile Ser Glu Ile Arg Thr Lys Glu Ala Phe Leu Arg Ser Ile 
    370                 375                 380                 


Ile Gly Val Ser Ser Ser Ala Tyr Phe Ser Leu Arg Asn Ile Leu Asn 
385                 390                 395                 400 


Thr Asp Asn Thr Gln Asp Ile Thr Asn Lys Val Lys Gly Glu Val Glu 
                405                 410                 415     


Lys Leu Tyr Gln Glu Asn Lys Lys Ile Lys Leu Glu Glu Arg Leu Lys 
            420                 425                 430         


Leu Phe Phe Gly Asn His Phe Asp Ile Asn Asn Gln Gln Glu Ile Glu 
        435                 440                 445             


Asp Phe Leu Met Asn Ile Asp Lys Ile Ile Ser Ser Ile Arg His Glu 
    450                 455                 460                 


Ile Ile His Phe Lys Ile Glu Ala Asn Ala Gln Asn Ile Phe Asp Phe 
465                 470                 475                 480 


Asn Asn Val Asn Leu Gly Asn Thr Ala Lys Asn Ile Phe Asn Asn Glu 
                485                 490                 495     


Ile Asn Glu Glu Arg Ile Lys Phe Lys Ile Phe Lys Gln Leu Asn Ser 
            500                 505                 510         


Ala Asn Val Phe Asp Tyr Leu Ser Asp Glu Asn Ile Thr Glu Tyr Met 
        515                 520                 525             


Gly Lys Ile Ile Phe Ser Phe Thr Asn Arg Asn Ile Pro Phe Val Pro 
    530                 535                 540                 


Ser Phe Arg Lys Ile Cys Asp Arg Val Gln Asp Leu Ala Asn Ser Leu 
545                 550                 555                 560 


Lys Ile Lys Glu Trp Lys Ile Ser Asp Glu Ser Glu Gly Lys Asp Ala 
                565                 570                 575     


Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asp Asp 
            580                 585                 590         


Phe Leu Asn Glu Lys Asn Glu Lys Phe Ile Lys Ile Lys Asp Glu Ile 
        595                 600                 605             


Ile Glu Leu Asn Lys Asn Gln Asn Lys Ile Thr Gly Phe Tyr Lys Leu 
    610                 615                 620                 


Glu Lys Phe Glu Lys Ile Glu Glu Lys Asn Pro Lys Lys Tyr Leu Glu 
625                 630                 635                 640 


Ile Ile Gln Ser Leu Tyr Met Ile Asn Ile Glu Glu Ile Asp Asn Glu 
                645                 650                 655     


Glu Lys Asn Ile Phe Leu Asp Phe Ile Gln Lys Ile Phe Leu Lys Gly 
            660                 665                 670         


Phe Phe Glu Phe Ile Lys Asn Asn Tyr Asn Tyr Leu Leu Lys Leu Lys 
        675                 680                 685             


Lys Val Gln Asp Lys Lys Asn Ile Phe Asp Arg Glu Met Ser Glu Tyr 
    690                 695                 700                 


Ile Ala Gly Glu Lys Thr Leu Glu Asp Met Glu Glu Ile Asn Lys Ile 
705                 710                 715                 720 


Ile Gln Asp Ile Lys Ile Thr Glu Ile Asp Lys Ile Leu Asn Gln Thr 
                725                 730                 735     


Asp Lys Ile Asn Cys Phe Tyr Leu Leu Leu Lys Leu Leu Asn Tyr Lys 
            740                 745                 750         


Glu Ile Thr Glu Leu Lys Gly Asn Leu Glu Lys Tyr Gln Ile Leu Ser 
        755                 760                 765             


Lys Thr Asn Ile Tyr Glu Lys Glu Leu Ile Leu Leu Asn Ile Val Asn 
    770                 775                 780                 


Leu Asp Asn Asn Lys Val Lys Ile Glu Asn Phe Lys Ile Ser Ala Glu 
785                 790                 795                 800 


Glu Ile Gly Lys Phe Ile Glu Lys Ile Gly Arg Asn Thr Lys Ile Glu 
                805                 810                 815     


Thr Phe Glu Glu Leu Arg Asn Phe Glu Lys Ile Glu Asn Ser Val Glu 
            820                 825                 830         


Cys Tyr Asn Ile Tyr Ser Asp Asp Lys Asn Ile Lys Asn Met Arg Asn 
        835                 840                 845             


Leu Tyr Asn Ile Lys Lys Tyr Gly Met Leu Asp Leu Leu Glu Arg Ile 
    850                 855                 860                 


Ser Glu Lys Thr Asn Tyr Cys Ile Lys Lys Lys Asp Leu Glu Glu Tyr 
865                 870                 875                 880 


Ser Lys Leu Arg Lys Gln Leu Glu Asp Glu Lys Thr Asn Phe Tyr Lys 
                885                 890                 895     


Ile Gln Lys Asp Leu His Tyr Glu 
            900                 


<210>  855
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  855

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Thr Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Lys Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Glu 
        755                 760                 765             


Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Lys Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Ile  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Arg Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1400                 1405                 1410         


<210>  856
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  856

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  857
<211>  1185
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  857

Met Arg Ile Ile Lys Pro Tyr Gly Arg Ser Val Val Glu Lys Ala Gly 
1               5                   10                  15      


Pro Gly Arg Leu Ala Arg Ala Val Ser Leu His Pro Asp Pro Ala Arg 
            20                  25                  30          


Gly Val Glu Leu Asp Asn Arg Lys Ser Val Val Glu Phe Ala Ala Ser 
        35                  40                  45              


His Asp Arg Leu Val Ile Ala Gln Trp Ile Ser Thr Ile Asp Lys Ile 
    50                  55                  60                  


Ala Arg Lys Pro Val Gly Glu Ala Ala Ala Thr Pro Gln Gln Ala Glu 
65                  70                  75                  80  


Phe Arg Arg Arg Leu Gly Asp Ala Ala Trp Thr Leu Ile Glu Arg Arg 
                85                  90                  95      


Ala Leu Leu Thr Gly Leu Asn Asp Pro Ala Val Lys Ala Arg Leu Arg 
            100                 105                 110         


Arg Leu Trp Glu Phe Lys Ile Ala Pro Tyr Lys Thr Ala Arg Ala Val 
        115                 120                 125             


Ala Lys Thr Gly Thr Arg Pro Pro Arg Leu Lys Gly Trp Trp Phe Arg 
    130                 135                 140                 


Arg Phe Ala Gly Asp Val Glu Glu Val Asp Lys Val Asp Ala Asp Ala 
145                 150                 155                 160 


Val Ala Leu Ala Ile His Glu His Leu Tyr Ser Ala Gln Tyr Gln Met 
                165                 170                 175     


Arg Val Asp Asp Arg Thr Arg Leu Ser Gly Leu Ile Ala Ala Arg Ala 
            180                 185                 190         


Glu Ser Ile Ala Gly Asn Val Leu Gln Pro His Ala Ala Ala Arg Asp 
        195                 200                 205             


Lys Asp Gly Gly Trp Ser Glu Asp Asp Gln Arg Arg Tyr Ala Ala Ala 
    210                 215                 220                 


Gly Asp Val Ala Arg Glu Ile Arg Ser Ala Ala Glu Ala Arg Glu Arg 
225                 230                 235                 240 


Gly Asp Gly Lys Ile Gly Pro Arg Arg Val Thr Ser Glu Val Ala Gly 
                245                 250                 255     


Ala Ala Leu Phe Glu His Tyr Ala Arg Leu Phe Arg Gly Ala Asp Gly 
            260                 265                 270         


Lys Ala Met Gly Val Ala Gln Ala Arg Asp Gln Glu Ser Gly Leu Phe 
        275                 280                 285             


Asn Leu His Met Ala Val Lys Asp Cys Tyr Ala Arg Ile Leu Lys Gly 
    290                 295                 300                 


His Gly Lys Asp Leu Ala Lys His Gly Glu Gly Arg Arg Arg Val Ser 
305                 310                 315                 320 


Thr Leu Leu Pro Pro Thr Ser Val Asp Leu Phe Arg Leu Leu Asp Ala 
                325                 330                 335     


Met Leu Asp Asn Arg Asp Leu Asn Ala Leu Val Arg Leu Gly Lys Val 
            340                 345                 350         


Ile His Tyr Glu Ser Ala Gly Ala Gly Val Asp Arg Pro Ala Asp Val 
        355                 360                 365             


Val Asp His Trp Pro Ala Asp Val Ala Asp Ser Asp Tyr Trp Thr Ser 
    370                 375                 380                 


Asp Gly Gln Ala Arg Ile Lys Arg Asn Glu Ala Leu Val Arg Val Trp 
385                 390                 395                 400 


Arg His Val Leu Ala Leu Ala Ser Arg Thr Leu Thr Asp Trp Ala Asp 
                405                 410                 415     


Pro Lys Gly Met Ile Gly Gly Asp Ile Leu Leu Lys Asp Ser Val Glu 
            420                 425                 430         


Thr Ala Ile Ala Asn Phe Asp Ala Glu Ser Tyr Lys Arg Lys Ile Glu 
        435                 440                 445             


Val Leu Phe Gly Gly Arg Ala Ala Leu Phe Asp Gly Asp Gly Asp Glu 
    450                 455                 460                 


Ala Phe Glu Lys Asp Val Leu Arg Phe Ala Leu His Gly Val Ala Ala 
465                 470                 475                 480 


Leu Arg Asn Ala Ala Phe His Phe Lys Gly Val Gly Gly Phe Ala Glu 
                485                 490                 495     


Ala Leu Lys Thr Leu Gly Pro Arg Gln Asp Pro Arg Val Thr Ala Ala 
            500                 505                 510         


Val Asp Gly Leu Trp Arg Thr Asp Glu Glu Gly Arg Gly Arg Arg Leu 
        515                 520                 525             


Leu Ala Thr Met Arg Gly Ala His Phe Glu Ser Phe Phe Asp Gln Arg 
    530                 535                 540                 


Gln Asn Arg Arg Leu Ala Gln Ala Leu Ser Arg Ala Ser Glu Glu Ser 
545                 550                 555                 560 


Leu Pro Leu Pro Arg Phe Ala Val Met Leu Arg Arg Ala Glu Asn Ala 
                565                 570                 575     


Trp Asp Arg Leu Gly Leu Pro Lys Thr Ala Asn Arg Ala Asp Leu Glu 
            580                 585                 590         


Ala Pro Ala Arg His Cys Gln Tyr Val Ala Leu Lys Leu Leu Tyr Glu 
        595                 600                 605             


Arg Pro Phe Arg Ala Trp Leu Ala Glu Arg Asp Ala Ala Thr Leu Asn 
    610                 615                 620                 


Arg Phe Ile Val Cys Ala Val Glu Arg Ala Thr Lys Ala Ala Arg Met 
625                 630                 635                 640 


Leu Asn Pro Gly Ala Ser Arg Glu Leu Ala Glu Ala Ile Thr Ala Lys 
                645                 650                 655     


Ala Ala Asp Leu Gly Arg Leu Gly Asn Asp Asp Ser Val Glu Asp Phe 
            660                 665                 670         


Phe Phe Arg Leu Ser Ala Glu Thr Ala Gly Glu Ala Arg Val Gln Arg 
        675                 680                 685             


Gly Tyr Glu Ser Asp Ala Glu Asn Ala Arg Ala Gln Ala Ser His Ile 
    690                 695                 700                 


Glu Asn Leu Lys Ala Asp Leu Val Ala Leu Ala Phe Arg Asp Tyr Leu 
705                 710                 715                 720 


Gln Lys Ala Asp Phe Glu Phe Ala Leu Lys Leu Arg Gly Asp Glu Pro 
                725                 730                 735     


Leu Pro Thr Lys Pro Met Cys Ala Leu Asp Glu Ala Asp Phe Val Glu 
            740                 745                 750         


Gly Glu Ala Ser Ser Ala Glu Pro Pro Cys Glu Leu Tyr Phe Leu Leu 
        755                 760                 765             


His Leu Val Pro Val Asp Glu Val Gly Lys Leu Leu His Gln Leu Arg 
    770                 775                 780                 


Lys Trp Gln Ile Leu Ala Pro Pro Ala Pro Ala Ala Thr Gly Gly Pro 
785                 790                 795                 800 


Thr Thr Ala Ala Thr Val Ala Glu Ile Arg Leu Ala Leu Glu Leu Tyr 
                805                 810                 815     


Leu Asp Met His Asp Ala Lys Phe Glu Gly Gly Ala Ala Leu Val Gly 
            820                 825                 830         


Val Glu Pro Phe Lys Arg Leu Phe Glu Gly Asp Gly Leu Phe Gly Arg 
        835                 840                 845             


Ile Phe Glu Arg Pro Ala Gly Asp Arg Pro Gly Ala Glu Asp Asp Arg 
    850                 855                 860                 


Arg Leu Pro Arg Arg Gly Leu Arg Glu Ile Met Arg Phe Gly His Leu 
865                 870                 875                 880 


Arg Pro Leu Leu Pro Ile Phe Asp Lys Gln Pro Ile Arg Ala Asp Glu 
                885                 890                 895     


Val Ala Ala Tyr Leu Asp Ala Glu Gln Val Pro Asp Gly Gly Lys Ser 
            900                 905                 910         


Glu Ile Ala Arg Arg Gln Glu Arg Arg Glu Ala Leu His Glu Lys Trp 
        915                 920                 925             


Ala Arg Arg Arg Arg Glu Phe Ser Asp Asp Asp Arg Arg Ala Tyr Glu 
    930                 935                 940                 


Glu Ala Leu Arg Phe Val Glu Glu His Arg His Arg Ala Ala Arg Val 
945                 950                 955                 960 


Thr Leu Thr Asp His Val Arg Leu His Arg Leu Leu Met Ala Val Leu 
                965                 970                 975     


Gly Arg Leu Val Asp Tyr Ser Gly Leu Trp Glu Arg Asp Leu Tyr Phe 
            980                 985                 990         


Val Ala Leu Ala Leu Ile His Gln  Ala Gly Arg Arg Leu  Asp Glu Ile 
        995                 1000                 1005             


Phe Ala  Ala Asp Gly Leu Ala  Met Leu Arg Glu Gly  Arg Val Val 
    1010                 1015                 1020             


Glu Ala  Leu Arg Lys Leu Ala  Asp Ile Asp Ala Ala  Arg Ala Ile 
    1025                 1030                 1035             


Ala Ala  Glu Val Lys Arg Arg  Phe Asp Gly Ala Pro  Asp Ala Ala 
    1040                 1045                 1050             


Ser Arg  Val Val Lys Ile Arg  Asn Ala Phe Ala His  Phe Asn Met 
    1055                 1060                 1065             


Leu Arg  Pro Lys Arg Gly Gly  Ala Thr Ala Ala Leu  Asp Leu Thr 
    1070                 1075                 1080             


Ala Ala  Val Asn Asp Gly Arg  Glu Leu Met Ala Tyr  Asp Arg Lys 
    1085                 1090                 1095             


Leu Lys  Asn Ala Val Ser Arg  Ser Ile Ala Glu Leu  Leu Glu Arg 
    1100                 1105                 1110             


Glu Gly  Leu Ala Val Ala Trp  Ser Val Asn Glu His  Arg Leu Glu 
    1115                 1120                 1125             


Ala Thr  Arg Val Ser Thr Arg  Gln Ala Ser His Leu  Ala Asn Ser 
    1130                 1135                 1140             


Gly Leu  Arg Glu Asp Leu His  Gly Ala Gly Tyr Val  Ala Thr Val 
    1145                 1150                 1155             


Ala Glu  Leu Phe Gly Arg Thr  Ala Ala Lys Pro Ala  Ala Pro Leu 
    1160                 1165                 1170             


Ala Arg  Arg Glu Asn Arg Thr  Ala Arg Gly Gly Arg  
    1175                 1180                 1185 


<210>  858
<211>  1140
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  858

Met Arg Gly Asp Tyr Met Lys Ile Thr Lys Ile Asp Gly Ile Ser His 
1               5                   10                  15      


Lys Lys Tyr Lys Glu Lys Gly Lys Leu Ile Lys Ser Asn Glu Ile Glu 
            20                  25                  30          


Lys Asp Val Thr Glu Glu Arg Phe Asn Asp Ile Glu Val Lys Thr Thr 
        35                  40                  45              


Glu Leu Phe Gln Lys Thr Leu Asp Phe Tyr Val Lys Asn Tyr Glu Lys 
    50                  55                  60                  


Cys Glu Glu Gln Asn Lys Glu Arg Arg Glu Lys Ala Lys Asn Tyr Phe 
65                  70                  75                  80  


Ser Lys Val Lys Leu Ile Val Asp Asn Lys Lys Ile Thr Ile Phe Asn 
                85                  90                  95      


Glu Asn Thr Glu Lys Ile Glu Ile Glu Gly Phe Asn Glu Tyr Asp Val 
            100                 105                 110         


Arg Asp Glu Lys Tyr Phe Asn Val Leu Asn Lys Ile Leu Lys Glu Glu 
        115                 120                 125             


Asn Cys Thr Glu Glu Asp Leu Glu Val Phe Glu Asn Asp Leu Gln Lys 
    130                 135                 140                 


Lys Leu Asn Gln Ile Gln Ser Ile Lys Asn Ser Leu Glu Glu Asn Lys 
145                 150                 155                 160 


Ala His Phe Lys Lys Glu Ser Val Asn Asn Thr Ala Asp Arg Val Lys 
                165                 170                 175     


Gly Asn Asn Lys Lys Ser Leu Phe Tyr Glu Tyr Tyr Arg Asn Ser Ser 
            180                 185                 190         


Lys His Gln Glu Tyr Val Asn Asn Ile Phe Glu Ala Phe Asp Lys Leu 
        195                 200                 205             


Tyr Ser Asn Ser His Glu Asp Met Asn Asn Leu Phe Ser Ala Ile Thr 
    210                 215                 220                 


Lys Asp Ser Asn Asp Arg Asn Ile Lys Lys Ile Arg Glu Ala Tyr His 
225                 230                 235                 240 


Glu Ile Leu Asn Lys Asn Lys Ile Glu Phe Gly Glu Glu Leu Tyr Lys 
                245                 250                 255     


Lys Ile Gln Asp Asn Ile Asn Asn Phe Asp Lys Leu Leu Glu Ile Glu 
            260                 265                 270         


Pro Glu Ile Lys Glu Leu Thr Lys Ser Gln Ile Phe Tyr Lys Tyr Tyr 
        275                 280                 285             


Ile Asp Lys Val Ser Leu Asp Gly Thr Asn Ile Lys His Cys Phe Ser 
    290                 295                 300                 


His Leu Val Glu Ile Glu Val Asn Gln Leu Leu Lys Asn Tyr Val Tyr 
305                 310                 315                 320 


Ser Lys Arg Ser Thr Asn Lys Glu Lys Leu Glu Asn Ile Phe Glu Tyr 
                325                 330                 335     


Cys Lys Leu Lys Asn Leu Val Lys Asn Lys Leu Val Asn Lys Leu Asn 
            340                 345                 350         


Ser Tyr Ile Arg Asn Cys Gly Lys Tyr Asn Ser Tyr Ile Asn Asn Asn 
        355                 360                 365             


Asp Val Val Asn Ser Glu Lys Ile Ser Glu Ile Arg Thr Lys Glu Ala 
    370                 375                 380                 


Phe Leu Arg Ser Thr Ile Gly Val Ser Ser Ser Ala Tyr Phe Ser Leu 
385                 390                 395                 400 


Arg Asn Ile Leu Asn Thr Asp Asn Thr Gln Asp Ile Thr Asn Lys Val 
                405                 410                 415     


Lys Gly Glu Val Glu Lys Leu Tyr Gln Glu Asn Lys Lys Val Lys Leu 
            420                 425                 430         


Glu Glu Arg Leu Lys Leu Phe Phe Gly Asn Asn Phe Asp Ile Asn Asn 
        435                 440                 445             


Gln Gln Glu Ile Glu Asp Phe Leu Met Asn Ile Asp Lys Ile Ile Ser 
    450                 455                 460                 


Asn Ile Arg His Glu Ile Ile His Phe Lys Ile Glu Ala Asn Ala His 
465                 470                 475                 480 


Ser Ile Phe Asp Phe Asn Asn Val Thr Leu Gly Asn Lys Ala Lys Asn 
                485                 490                 495     


Ile Phe Asn Asn Glu Ile Asn Glu Glu Arg Ile Lys Phe Lys Ile Phe 
            500                 505                 510         


Lys Gln Leu Asn Ser Ala Asn Val Phe Asp Tyr Leu Ser Asp Glu Asn 
        515                 520                 525             


Ile Thr Glu Tyr Met Gly Lys Val Ile Phe Ser Phe Thr Asn Arg Asn 
    530                 535                 540                 


Ile Pro Phe Val Pro Ser Phe Arg Lys Ile Tyr Asn Arg Val Gln Asp 
545                 550                 555                 560 


Leu Ala Asn Ser Leu Lys Ile Lys Glu Trp Lys Ile Ser Asp Glu Ser 
                565                 570                 575     


Glu Gly Lys Asp Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly 
            580                 585                 590         


Glu Phe Leu Asp Glu Phe Leu Asn Glu Glu Asn Gly Ile Phe Ile Ser 
        595                 600                 605             


Ile Lys Asp Lys Ile Ile Glu Leu Asn Arg Asn Gln Asn Lys Arg Thr 
    610                 615                 620                 


Gly Phe Tyr Lys Leu Glu Lys Phe Glu Lys Ile Glu Glu Lys Asn Pro 
625                 630                 635                 640 


Lys Lys Tyr Leu Glu Ile Ile Gln Ser Leu Tyr Met Ile Asn Ile Glu 
                645                 650                 655     


Glu Ile Asp Asn Glu Glu Lys Asn Ile Phe Leu Asp Phe Ile Gln Lys 
            660                 665                 670         


Ile Phe Leu Lys Gly Phe Phe Glu Phe Ile Lys Asn Asn Tyr Asn Tyr 
        675                 680                 685             


Leu Leu Glu Leu Lys Lys Ile Gln Asp Lys Lys Asn Ile Phe Asp Ser 
    690                 695                 700                 


Glu Met Ser Glu Tyr Ile Ala Gly Glu Lys Thr Leu Glu Asp Ile Gly 
705                 710                 715                 720 


Glu Ile Asn Glu Ile Ile Gln Lys Ile Glu Ile Thr Lys Ile Asp Lys 
                725                 730                 735     


Ile Leu Asn Leu Thr Asp Lys Ile Asn Cys Phe Tyr Leu Leu Leu Lys 
            740                 745                 750         


Leu Leu Asn Tyr Lys Glu Ile Thr Glu Leu Lys Gly Asn Leu Glu Lys 
        755                 760                 765             


Tyr Gln Ile Leu Ser Lys Thr Asp Ile Tyr Glu Lys Glu Leu Ile Leu 
    770                 775                 780                 


Leu Asn Ile Val Asn Leu Asp Asn Asn Lys Val Lys Ile Glu Lys Phe 
785                 790                 795                 800 


Lys Ile Ser Ala Glu Glu Ile Gly Lys Phe Ile Glu Lys Ile Ser Arg 
                805                 810                 815     


Asn Lys Lys Ile Lys Thr Phe Glu Glu Leu Arg Asn Phe Glu Lys Arg 
            820                 825                 830         


Glu Asn Thr Gly Glu Tyr Tyr Asn Val Tyr Ser Asp Asp Lys Asn Ile 
        835                 840                 845             


Lys Asn Ile Arg Asn Leu Tyr Asn Ile Lys Lys Tyr Gly Met Leu Asp 
    850                 855                 860                 


Leu Leu Glu Arg Ile Ser Glu Lys Ser Asn Tyr Cys Ile Lys Lys Glu 
865                 870                 875                 880 


Asp Leu Glu Glu Tyr Ser Glu Leu Arg Lys Gln Leu Glu Asp Glu Lys 
                885                 890                 895     


Thr Asn Phe Tyr Lys Ile Gln Lys Asp Leu His Tyr Glu Tyr Gln Lys 
            900                 905                 910         


Lys Tyr Lys Asn Phe Ser Lys Lys Asn Asn Pro Glu Asp Tyr Glu Lys 
        915                 920                 925             


Tyr Lys Glu Ser Ile Lys Asn Ile Glu Lys Tyr Val His Leu Lys Asn 
    930                 935                 940                 


Lys Ile Glu Phe Asn Glu Leu Asn Leu Leu Gln Ser Leu Leu Leu Lys 
945                 950                 955                 960 


Ile Leu His Arg Leu Val Gly Phe Thr Ser Ile Trp Glu Arg Asp Leu 
                965                 970                 975     


Arg Phe Arg Leu Ile Gly Glu Phe Pro Asp Glu Leu Asp Val Glu Asp 
            980                 985                 990         


Ile Phe Asp His Arg Glu Arg Tyr  Arg Gly Thr Arg Gly  Gln Ile Cys 
        995                 1000                 1005             


Lys Lys  Tyr Asp Gln Phe Ile  Ser Val His Ile Glu  Tyr Gln Asn 
    1010                 1015                 1020             


Asn Asn  Lys Met Lys Asn Ile  Lys Phe Asp Asp Asn  Asn Pro Ile 
    1025                 1030                 1035             


Arg Asn  Tyr Ile Ala His Phe  Asn Tyr Leu Pro Thr  Pro Lys Tyr 
    1040                 1045                 1050             


Ser Ile  Leu Lys Met Leu Gly  Lys Leu Arg Glu Leu  Leu Asp Tyr 
    1055                 1060                 1065             


Asp Arg  Lys Leu Lys Asn Ala  Val Met Lys Ser Ile  Lys Asp Ile 
    1070                 1075                 1080             


Leu Glu  Glu Tyr Gly Phe Lys  Ala Glu Phe Val Ile  Asn Pro Asp 
    1085                 1090                 1095             


Lys Glu  Ile Ile Leu Asn Ser  Val Lys Ser Val Glu  Ile Ile His 
    1100                 1105                 1110             


Leu Lys  Lys Asn Asp Leu Asn  Ser His Arg Asn Ser  Glu Asp Leu 
    1115                 1120                 1125             


Cys Lys  Leu Val Lys Ala Met  Leu Glu Tyr Ser Glu  
    1130                 1135                 1140 


<210>  859
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  859

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Tyr Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  860
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  860

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Tyr Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  861
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  861

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  862
<211>  1191
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  862

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu 
    1190     


<210>  863
<211>  1130
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  863

Met Lys Val Ser Lys Val Lys Val Lys Val Gly Ala Gly Arg Ser Ser 
1               5                   10                  15      


Glu Arg Met Val Phe Met Arg Arg Thr Ser Lys Ile Gly Ser Leu Val 
            20                  25                  30          


Tyr Glu Asp Glu Gln Arg Asn Gly Lys Pro Glu Thr Asp Asp Lys Thr 
        35                  40                  45              


Thr Ser Ile Leu Pro Asp Lys Lys Arg Asp Ser Phe Ile Leu Ser Ile 
    50                  55                  60                  


Val Asn Lys Thr Ile Pro Lys Lys Glu Ile Val Lys Lys Asn Leu Gly 
65                  70                  75                  80  


Lys Gly Phe Val Asn Glu Tyr Tyr Asn Ala Ile Ala Gly Ile Ile Asp 
                85                  90                  95      


Ser Phe Leu Glu Lys Lys Ile Val Asp Arg Lys His Tyr Ile Ile Val 
            100                 105                 110         


Asn Lys Leu Thr Glu Glu Glu Ile Lys Gln Tyr Leu Asn His Arg Phe 
        115                 120                 125             


Gln Glu Ala Asn Tyr Lys Tyr Val Arg Asp Lys Glu Glu Val Asn Phe 
    130                 135                 140                 


Asn Leu Pro Lys Leu Leu Lys Glu Ser Ala Lys Ser Asn Ser Thr Ala 
145                 150                 155                 160 


Pro Leu Gln Pro Tyr Lys Glu Trp Ala Glu Trp His Ile Glu Thr Lys 
                165                 170                 175     


Ser Val Arg Leu Ile Arg Ser Ile Gln Asn Asn Arg Leu Val Ile Asp 
            180                 185                 190         


Thr Gln Glu Glu Ala Glu Asn Met Ser Pro Arg Lys Arg Ala Leu Leu 
        195                 200                 205             


Lys Trp Glu Asn Glu Phe Leu Leu Ser His Lys Leu Asp Leu Gln Asp 
    210                 215                 220                 


Val Glu Lys Thr Tyr Leu Ile Asp Asp Leu Ile His Ala Leu His Glu 
225                 230                 235                 240 


Val Thr Tyr Thr Thr Asn Asp Lys Gly Phe Ile Asn Gly Asn Glu Tyr 
                245                 250                 255     


His Arg Phe Leu Lys Lys Ala Leu Gln Ser His Gln Gln Asn Ile Phe 
            260                 265                 270         


Gly Ser Arg Glu Thr Pro Asn Lys Val Asn Arg Glu Asn Ala Glu Leu 
        275                 280                 285             


Tyr Ser Tyr Asn Met Glu Val Val Lys Tyr Leu Glu His Tyr Phe Pro 
    290                 295                 300                 


Ile Lys Lys Thr Asn Arg Arg Asn Thr Leu Asp Thr Lys Asp Tyr Tyr 
305                 310                 315                 320 


Leu Asn Gly Ile Asn Ile Lys Asp Arg Val Arg Lys Gln Leu Glu Asn 
                325                 330                 335     


Ala Val Arg Asn Asn Leu Val Arg Gln Gly Lys Tyr Thr Leu His Thr 
            340                 345                 350         


Leu Thr Thr Asp Thr Ala Asn Ser Asp Asn Leu Ser Lys Ile Lys Ala 
        355                 360                 365             


Asp Glu Gly Phe Ala Leu Thr Met Leu Asn Gln Cys Ala Phe Ala Ala 
    370                 375                 380                 


Asn Asn Val Arg Asn Ile Ile Asp Pro Thr Gln Val Glu Asp Ile Leu 
385                 390                 395                 400 


Leu Asp Arg Pro Phe Asn Glu Ser Leu Glu Lys Phe Asn Ser Ala Gln 
                405                 410                 415     


Met Leu His Leu Ser Ser Phe Phe Asp Val Lys Glu Phe Asn Glu Pro 
            420                 425                 430         


Leu Arg Ala Ile Arg Asp Ala Val Ala Lys Ile Arg His Asn Ile Ile 
        435                 440                 445             


His Tyr Lys Val Asn Ala Leu Asn Val Ile Phe Lys Ile Glu Thr Phe 
    450                 455                 460                 


Gly Ser Thr Glu Lys Gln Tyr Lys Asp Thr Ile Phe Gly Ser Leu Leu 
465                 470                 475                 480 


Gln Ala Asp Met Met Asn Val Ser Glu Ser Leu Ala Lys Gln Leu Met 
                485                 490                 495     


Thr Gly Asn Val Leu Glu Tyr Tyr Pro Met Leu Glu Leu Lys Ser Phe 
            500                 505                 510         


Phe Ser Lys Asn Ser Ile Ser Leu Tyr Arg Ser Val Ile Pro Phe Ala 
        515                 520                 525             


Pro Gly Phe Lys Arg Val Met Lys Lys Gly Glu Asn Tyr Gln Asn Ala 
    530                 535                 540                 


Asn Asn Lys Asp Asp Lys Ser Lys Tyr Tyr Asn Leu Lys Ile Glu Ser 
545                 550                 555                 560 


Phe Leu Pro Gln Glu Ser Phe Thr Lys Glu Ala Tyr Asp Ala Arg Tyr 
                565                 570                 575     


Phe Leu Leu Lys Leu Ile Tyr Asn Asn Ile Phe Leu Pro Lys Phe Thr 
            580                 585                 590         


Glu Ser Thr Asp Trp Phe Lys Ser Thr Val Asn Gly Val Ile Ala Leu 
        595                 600                 605             


Asn Arg Glu Glu Asn Val Arg Lys Gly Lys Lys His Lys Ile Ala Phe 
    610                 615                 620                 


Ala Glu Ile Arg Leu Met Asp Ser Arg Asp Thr Ile Gly Thr Tyr Ala 
625                 630                 635                 640 


Ala Tyr Leu Gln Ser Cys Ala Ile Ile Glu Ala Asn Lys Lys Pro Asp 
                645                 650                 655     


Ala Ala Lys Asp Glu Thr Val Leu Leu Asn Phe Glu Lys Leu Ile Leu 
            660                 665                 670         


Gln Ile Phe Ile Lys Gly Phe Asp Asp Phe Leu Arg Arg Tyr Gly Met 
        675                 680                 685             


Leu Lys Phe Val Gln Gln Pro Ser Leu Gln Phe Lys Ser Gly Ala Lys 
    690                 695                 700                 


Asp Glu Thr Lys Gln Arg Lys Asp Trp Ala Lys Glu Val Glu Gly Ser 
705                 710                 715                 720 


Leu His Ala Pro Val Asn Asp Ile Asn Pro Thr Glu Ser Ser His Ile 
                725                 730                 735     


Ser Phe Tyr Val Phe Cys Lys Leu Leu Asp Ala Pro His Leu Asn Asp 
            740                 745                 750         


Leu Arg Asn Glu Leu Ile Lys Tyr Tyr Arg Ser Gln Ser His Arg Pro 
        755                 760                 765             


Gln Lys Ile Lys Asn Ile Lys Tyr Leu Leu Ser Ile Ile Glu Leu Cys 
    770                 775                 780                 


Leu Leu Ser Val Asp Ala Ser Glu Leu Asn Lys Leu Phe Thr Asp Ala 
785                 790                 795                 800 


Asp Asn Ser Ile Asn Asp Arg Leu Leu Ala Phe Leu Glu Lys Asn Lys 
                805                 810                 815     


Thr Val Ala Asp Tyr Glu Asp Leu Tyr Thr Gln Ser Asp Asn Glu Thr 
            820                 825                 830         


Met Val Leu His Arg Thr Ile Ala Lys Ala Tyr Lys Tyr Gly Thr Arg 
        835                 840                 845             


Lys Val Leu Glu Gln Val Ile Asp Ser Asp Pro Ser Tyr Arg Val Thr 
    850                 855                 860                 


Val Ser Glu Tyr Glu Glu Trp Lys Asn Leu Lys Glu Asn Val Glu Glu 
865                 870                 875                 880 


Trp Ile Ala Cys Arg Glu Lys Leu His Ala Lys Trp Val Lys Val Glu 
                885                 890                 895     


Arg Val Pro Lys Met Lys Glu Gly Glu Met Lys Asp Asp Met Lys Glu 
            900                 905                 910         


Tyr Val Glu Val Cys Ser Thr Ile Asp Arg Tyr Asn Trp Leu Asp Asn 
        915                 920                 925             


Lys Val His Leu Glu His Ile Asn Lys Leu His Asn Leu Thr Ile Asp 
    930                 935                 940                 


Leu Leu Gly Arg Met Ala Gly Phe Asn Thr Leu Phe Glu Arg Asp Leu 
945                 950                 955                 960 


Gln Tyr Tyr Cys Asn Cys Asn Glu Lys Val Arg Ser Leu Leu Lys Pro 
                965                 970                 975     


Glu Ser Ser Glu Gly Phe Asp Phe Ser Lys Gly Leu Pro Lys Phe Thr 
            980                 985                 990         


Glu Glu Gln Asn Ser Ile Leu Phe  Gln Thr Phe Leu Val  Glu Gly Tyr 
        995                 1000                 1005             


Arg Asp  Thr Arg Asn Phe Val  Ala His Phe Asn Phe  Leu Asn Ser 
    1010                 1015                 1020             


Phe Glu  Asp Ser Tyr Ser Lys  Asn Arg Tyr Ser Leu  Ile Asp Val 
    1025                 1030                 1035             


Ile Asn  Arg Leu Arg Lys Gln  Phe Lys Tyr Asp Arg  Lys Leu Lys 
    1040                 1045                 1050             


Asn Ala  Val Ser Lys Ala Ile  Ile Lys Leu Phe Glu  Lys His Gly 
    1055                 1060                 1065             


Met Val  Leu Thr Phe Ser Phe  Glu Gly Asp His Glu  Leu Val Val 
    1070                 1075                 1080             


Lys Asp  Val Phe Pro Arg Lys  Ile Ile His Phe Ser  Lys Leu Lys 
    1085                 1090                 1095             


Leu Asp  Lys Lys Ile Glu Gln  Lys Pro Lys Val Glu  Thr Asp Met 
    1100                 1105                 1110             


Val Pro  Lys Glu Phe Cys Ala  Met Cys Lys Phe Leu  Leu Glu Leu 
    1115                 1120                 1125             


Lys Lys  
    1130 


<210>  864
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  864

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Pro Gly Thr Asp Thr 
            20                  25                  30          


Ile Asp Leu Lys Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Lys Val Phe Asn Gln Ile Gln Val Gly Asn Lys Pro Lys Lys 
    50                  55                  60                  


Trp Lys Lys Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Glu Tyr Val Glu Ser Ser Gln Arg Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Asp Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Glu Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Gly Leu Phe Val Asn Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Ile Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Ser Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Tyr Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Lys Asp Arg Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Lys Glu Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Gln Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Phe 
            660                 665                 670         


Ile Arg Lys Asn Phe Pro Glu Asp Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Lys Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Tyr 
                805                 810                 815     


Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Thr 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Asp Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Asp Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asn  Ser Glu Lys Lys Glu  Ala Tyr Gln Lys Ile  Glu Val Asn 
    1100                 1105                 1110             


Gly Asp  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Val  Tyr Ala Pro Asp Glu  Lys Gly Asp 
    1130                 1135                 1140             


Ile Leu  Lys Glu Gln Cys Thr  Lys Gly Gly Ala Gly  Gly Lys Ile 
    1145                 1150                 1155             


Ser Ala  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Lys Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Lys Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Lys Gln 
    1250                 1255                 1260             


Thr Thr  Ser Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Ser Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Lys  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Val Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Gly Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Pro Asn 
    1370                 1375                 1380         


<210>  865
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  865

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  866
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  866

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  867
<211>  1187
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  867

Met Lys Ile Ile Arg Pro Tyr Gly Ser Ser Ser Thr Asp Leu Asn Glu 
1               5                   10                  15      


Arg Ser Leu Ser Asp Lys Asn Glu Gln Lys Gln Glu Ile Thr Leu Tyr 
            20                  25                  30          


Cys Thr Glu His Glu Glu Leu Val Ile Ala Gln Trp Ile Ser Ile Ile 
        35                  40                  45              


Asp Lys Ile Ile Ile Lys Pro Lys Gln Asp Lys Ala Pro Ser Asp Glu 
    50                  55                  60                  


Gln Arg Ser Ala Arg Thr Lys Ile Gly Glu Ala Ala Trp Lys Leu Ile 
65                  70                  75                  80  


Ile Ala Asp Met Arg Leu Lys Thr Arg Asp Thr Ala Arg Leu Ala His 
                85                  90                  95      


Leu Ala Arg Leu Trp Asn Phe Lys Ile His Pro Tyr Gly Thr Lys Thr 
            100                 105                 110         


Gly Asn Gln Asn Ser Asn His Gly Arg Pro Leu Pro Ser Ile Lys Gly 
        115                 120                 125             


Arg Trp Tyr Lys Val Phe Val Gly Asp Asn Val Pro Val Glu Asp Ile 
    130                 135                 140                 


Asn Pro Gln Asp Thr Ala Gln Arg Ile Ser Glu His Leu Tyr Glu Ala 
145                 150                 155                 160 


Glu Tyr Arg Ile Lys Leu Gly His Pro Lys Arg Arg Lys Gly Leu Ile 
                165                 170                 175     


Gln Ala Arg Ala Glu Ser Ile Lys Lys Asn Val Pro Ser Lys Lys Gln 
            180                 185                 190         


Pro Ala Thr Gln Pro Thr Trp Ser Asp Gly Asp Ile Glu Arg Tyr Thr 
        195                 200                 205             


Lys His Gly Asp Val Ala Ala Ala Ile Trp Asn Lys Ala Thr Glu Cys 
    210                 215                 220                 


Glu Thr Asn Lys Lys Pro Val Arg Leu Asp Ile Ala Ala Ala Cys Leu 
225                 230                 235                 240 


Tyr Asp His Trp Ala Lys Ile Phe Phe Asp Pro Ala Thr Lys Ala Val 
                245                 250                 255     


Leu Asn Ile Thr Gln Ala Lys Asp Lys Glu Pro Asn Leu Tyr Ala Leu 
            260                 265                 270         


His Met Ala Ile Lys Arg Thr Tyr Thr Arg Ile Leu Lys Asn His Arg 
        275                 280                 285             


Lys Asn Thr Lys Asp Gln Gln Asn Lys Asn Ala Asn Asn Asn Arg Lys 
    290                 295                 300                 


Ile Ser Ser Ile Leu Pro Arg Asp Met Gln Glu Leu Leu Arg Met Ser 
305                 310                 315                 320 


Arg Asp Gln Lys Asp Asn Thr Asp Ile Ala Ser Leu Val Arg Leu Gly 
                325                 330                 335     


Lys Ile Ile His Tyr Thr Ala Ser Asp Asn Asp His Asp Asn Thr Lys 
            340                 345                 350         


Asn Ile Ile Ala Asn Trp Pro Gln Asp Val Ser Gln Ser Arg Phe Trp 
        355                 360                 365             


Thr Ser Asp Gly Gln Ala Glu Ile Lys Arg Ala Glu Ser Phe Val Arg 
    370                 375                 380                 


Val Trp Arg Arg Thr Leu Ser Tyr Ala Thr Leu Thr Leu Arg Asn Trp 
385                 390                 395                 400 


Ala Ser Ile Glu Ala Glu Asp Ala Glu Gln Asp Leu Leu Gly Ser Gly 
                405                 410                 415     


Asp Ala Ile Ala Gly Ala Ile Glu Lys Ile Lys His Asn Tyr Asp His 
            420                 425                 430         


Asp Thr Phe Lys Lys Lys Thr Glu Leu Leu Phe Gly Lys Arg Ala Ala 
        435                 440                 445             


Ser Leu Leu Ser Asp Lys Asp Lys Asn Thr Glu Leu Leu Asn Phe Ala 
    450                 455                 460                 


Leu Lys Gly Ala Arg Asp Leu Arg Asn Ala Ser Phe His Phe Lys Gly 
465                 470                 475                 480 


Leu Gly Met Phe Ile Lys Gln Leu Glu Ala Leu Glu Gln Asp Ser Arg 
                485                 490                 495     


Ala Lys Asp Leu Trp Glu Gln Asp Asn Ala Asp Tyr Ala Glu Ser Ile 
            500                 505                 510         


Arg Ala Lys Leu Lys Gly Ala His Ala Glu Phe Phe Phe Thr Gln Thr 
        515                 520                 525             


Gln Asn Glu Gln Leu Leu Thr Leu Leu Ala Lys Pro Asn Glu Asn Ala 
    530                 535                 540                 


Leu Pro Leu Pro Arg Phe Ser Arg Val Leu Leu Arg Ala Glu Asn Thr 
545                 550                 555                 560 


Arg Asp Thr Asn Asn Pro Cys Gln Leu Pro Ala Pro Thr Asn Arg Thr 
                565                 570                 575     


Glu Leu Glu Glu Asn Pro Ala Arg Leu Cys Gln Tyr Thr Ala Leu Lys 
            580                 585                 590         


Ser Val Tyr Glu Lys Asp Phe Arg Val Trp Leu Thr Glu Lys Lys Gly 
        595                 600                 605             


Asp Ala Leu His Asn Trp Ile Asp Ser Ala Ile Lys Arg Thr Thr Lys 
    610                 615                 620                 


Ala Ala Arg Thr Ile Asn Gly Lys Lys Asp Glu Asn Asn Arg Asp Leu 
625                 630                 635                 640 


Ile Ile Ser Lys Ala Ala Gly Leu Pro Lys Pro Lys Ala Glu Asp Gly 
                645                 650                 655     


Ile Ala Gln Phe Leu Phe Lys Leu Ser Ala Ala Thr Ala Ser Glu Met 
            660                 665                 670         


Arg Val Gln Arg Gly Tyr Glu Ser Asp Gly Glu Lys Ala Lys Glu Gln 
        675                 680                 685             


Ala Glu Tyr Ile Asp Glu Phe Leu Cys Asp Val Ile Ala Leu Ala Leu 
    690                 695                 700                 


Ala Asp Tyr Leu Lys Glu Lys Gly Leu Gln Trp Leu Ala Ala Leu Lys 
705                 710                 715                 720 


Pro Asp Gln Pro Lys Ala Tyr Gln Met Ser Tyr Leu Glu Lys Ile Pro 
                725                 730                 735     


Leu Pro Lys Leu Thr Asp Arg Ser Glu Glu Trp Gln Ala Thr Leu Tyr 
            740                 745                 750         


Leu Leu Leu His Met Ile Pro Val Glu Asp Ala Gly Lys Leu Leu His 
        755                 760                 765             


Gln Ile Lys Lys Trp Glu Ile Thr Ala Ser Arg Pro Thr Ala Ser Lys 
    770                 775                 780                 


Ser Lys Thr Leu Glu Ser Leu Thr Pro Leu Leu Arg Val Leu His Leu 
785                 790                 795                 800 


Tyr Leu Asp Met His Asp Ala Lys Phe Glu Gly Gly Met Ser Leu Ala 
                805                 810                 815     


Ser Cys Glu Lys Phe Ser Ala Phe Phe Glu Thr Gln Gly Gly Phe Asp 
            820                 825                 830         


Thr Ile Phe Pro Lys Asp Pro Ser Pro Asp Ala Gln Asp Arg Ile Pro 
        835                 840                 845             


Lys Arg Gly Leu Arg Glu Val Met Arg Phe Gly His Phe Pro Leu Leu 
    850                 855                 860                 


Gln Lys Ile Ser Thr Lys Lys Ile Thr Asn Glu Met Ile Glu Glu Met 
865                 870                 875                 880 


Leu Glu Gln Glu Lys Ile Ala Pro Ser Glu Lys Leu Ser Lys Ile Ala 
                885                 890                 895     


Lys Ala Gln His Gln Arg Glu Asp Ile His Lys Lys Trp Ala Lys Ala 
            900                 905                 910         


Pro Lys Asn Leu Ser Asn Asn Asp Lys Arg Ala Tyr Cys Glu Ala Leu 
        915                 920                 925             


Arg Ile Val Ile Asn His Arg Lys Asn Ala Ala Gln Val Asn Leu Val 
    930                 935                 940                 


Asn His Val Arg Ile His Arg Leu Leu Met Ser Val Leu Ala Arg Leu 
945                 950                 955                 960 


Leu Asp Tyr Ser Gly Leu Phe Glu Arg Asp Leu Tyr Phe Val Thr Leu 
                965                 970                 975     


Ala His Ile His Leu Ala Arg Lys Lys Thr Asp Asp Phe Ser Thr Asn 
            980                 985                 990         


Lys Glu Asn Arg Asp Lys Ile Arg  Asp Lys Leu Lys Asn  Gly Gln Ile 
        995                 1000                 1005             


Ile Glu  Ser Leu Asn Ile Val  Asn Gln Asn Glu Asp  Ala Lys Thr 
    1010                 1015                 1020             


Leu Cys  Glu Asn Ile Ala His  His Phe Gly Ser Val  Trp Glu Glu 
    1025                 1030                 1035             


Asn Asn  Asn Ile Gln Ile Ile  Arg Asn Asn Leu Ser  His Phe Asn 
    1040                 1045                 1050             


Met Leu  Glu Leu Asn Gln Pro  Ile Pro Asp Leu Thr  His Trp Val 
    1055                 1060                 1065             


Asn Gln  Thr Arg Lys Leu Val  Ala Tyr Asp Arg Lys  Leu Lys Asn 
    1070                 1075                 1080             


Ala Val  Ser Gln Ser Val Asn  Glu Leu Leu Gln Arg  Glu Gly Ile 
    1085                 1090                 1095             


Ile Ile  Asp Trp Val Met Asn  Lys Asp His Gln Leu  Glu Asn Pro 
    1100                 1105                 1110             


Ser Val  Thr Thr Ala Tyr Ala  Thr His Leu Lys Thr  Lys Ser Ile 
    1115                 1120                 1125             


Gln Glu  Ala Leu His Gly Glu  Asp Tyr Ile His Met  Val Val Ala 
    1130                 1135                 1140             


Leu Leu  Lys Gly His Ile Ser  Pro Lys Ile Thr Asp  Ile Thr Thr 
    1145                 1150                 1155             


Thr Ser  Ile Asp Glu Ile Leu  Arg Glu Asn Ala Pro  Lys Asn Lys 
    1160                 1165                 1170             


Asn Tyr  Gly Asn Lys Asn His  Arg Asn His Ala Lys  Arg Pro 
    1175                 1180                 1185         


<210>  868
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  868

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  869
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  869

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  870
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  870

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Pro Gly Thr Asp Thr 
            20                  25                  30          


Ile Gly Leu Lys Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Asp Lys Pro Lys Lys 
    50                  55                  60                  


Trp Lys Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Glu Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Ser Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Met Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Tyr Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ser Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Gln Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Leu Tyr Asn Ser Val Phe 
            660                 665                 670         


Ile Arg Lys Asn Phe Pro Glu Asp Ile Ser Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val Tyr Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Asp Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Asp Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asn  Ser Glu Lys Lys Glu  Ala Tyr Gln Lys Ile  Glu Val Asn 
    1100                 1105                 1110             


Gly Asp  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Val  Tyr Ala Pro Asp Glu  Lys Gly Asp 
    1130                 1135                 1140             


Ile Leu  Lys Glu Gln Cys Thr  Lys Gly Gly Ala Gly  Gly Lys Ile 
    1145                 1150                 1155             


Ser Ala  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Lys Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Lys Gln 
    1250                 1255                 1260             


Thr Thr  Ser Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Ser Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Lys  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Val Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Gly Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Pro Asn 
    1370                 1375                 1380         


<210>  871
<211>  1128
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  871

Met Leu Tyr Val Lys Pro Tyr Gly Lys Thr Glu Thr Ile Arg Thr Pro 
1               5                   10                  15      


Asp Gly Ser Leu Ile Arg Lys Leu Val Val Pro Thr Asp Gly Ala Pro 
            20                  25                  30          


Pro Lys Ser Val Ser Leu Ser Asp Phe Tyr Asn Asn Asp Pro Val Phe 
        35                  40                  45              


Leu Leu Ser Lys Ile Ile Ser Glu Phe Asp Gly Ile Ala Arg Lys Ser 
    50                  55                  60                  


Leu Asn Gln Gln Thr Ser Lys Arg Gln Arg Ala Phe Arg Asp Lys Leu 
65                  70                  75                  80  


Gly Pro Thr Val Trp Gly Tyr Phe Arg Thr Tyr Glu Cys Phe Ala Glu 
                85                  90                  95      


Lys Leu Ser Tyr Trp Asp Lys Leu Trp Leu Thr Lys Leu His Pro Tyr 
            100                 105                 110         


Asp Gly Lys Pro Leu Lys Gly Thr Thr Gln Arg Asp Thr Glu Asp Arg 
        115                 120                 125             


Lys Gly Arg Trp Tyr Tyr Thr Tyr Phe Gly Lys Thr Pro Val Asp Asp 
    130                 135                 140                 


Val Val Pro Asp Gly Leu Gly Glu Leu Ile Glu Asp Ser Leu Ile Arg 
145                 150                 155                 160 


Asn Ala Lys Ser Met Asn Gly Gly Leu Ile Ser Val Gly Arg Thr Thr 
                165                 170                 175     


Glu Asp Arg Gly Ala Lys Gly Lys Ile Asp Ala Ala Ala Arg Thr Ile 
            180                 185                 190         


Ser Gln Asn Ile His Ser Ala Ala Lys Ser Ile Ser Thr Gly Asp Ala 
        195                 200                 205             


His Trp Ser Lys Glu Asp Glu Lys Arg Tyr Glu Arg Ala Gly Asp Val 
    210                 215                 220                 


Ala Ala Leu Ile Gln Ser Thr Leu Arg Asp Tyr Ile Arg Ser Ala Ser 
225                 230                 235                 240 


Val Asp Arg Cys Pro Pro Lys Lys Arg Ile Gly Pro Ile Phe Phe Glu 
                245                 250                 255     


Gln Phe Ala Arg Leu Phe Pro Arg Glu Asp Leu Asp Glu Thr Gln Lys 
            260                 265                 270         


Pro Val Leu Thr Ile Lys Glu Ile Tyr Glu Glu Pro Asp Leu Glu Arg 
        275                 280                 285             


Leu Leu His Leu His Met Ser Ile Lys Asp Tyr Tyr Asn Asn Ala Phe 
    290                 295                 300                 


Arg Gly Gln Arg Arg Ala Gly Thr Leu Gln Asp Val Leu Pro Lys Asn 
305                 310                 315                 320 


Met Thr Ser Leu Phe Arg Met Leu Lys Ala Arg Lys Asp Asn Lys Ser 
                325                 330                 335     


Val Asn Gly Leu Ile Arg Leu Gly Lys Val Ile His Tyr Ser Cys Ala 
            340                 345                 350         


Gln Ser Pro Glu Thr Asp Thr Pro Arg Asp Val Thr Asn Ala Gln Leu 
        355                 360                 365             


Trp Gln Ser Asp Val Ser Asn Ser Met Phe Trp Thr Ser Ala Gly Gln 
    370                 375                 380                 


Ser Met Ile Lys Arg Asn Glu Ser Phe Val Arg Ile Trp Arg Gly Ala 
385                 390                 395                 400 


Ile Val Ile Ala Ala His Thr Leu His His Asn Ile Asp Pro Glu Gly 
                405                 410                 415     


Arg Leu Ser Asp Asp Ile Leu Leu Ser Lys Gly Arg Lys Phe Leu Gln 
            420                 425                 430         


Glu Asn Tyr Ser Asp Ala Thr Thr Gln Ser Arg Leu Lys Ile Leu Phe 
        435                 440                 445             


Gly Ala Arg Ser Glu Cys Phe Asp His Leu Ser Pro Glu Asn Arg Gln 
    450                 455                 460                 


Asn Leu Met Glu Val Leu Arg Ala Gly Leu Glu Asn Tyr Arg Asn Asn 
465                 470                 475                 480 


Gly Phe His Phe Lys Gly Arg Gly Gly Phe Val Asp Ser Leu Ser Val 
                485                 490                 495     


Ile Lys Gly Asn Leu Pro Thr Glu Ile Glu Thr Ala Leu Arg Asp Leu 
            500                 505                 510         


Leu Ser Arg Asp Arg Asn Ala Leu Ile Ala Arg Asn Arg Ala Ala Leu 
        515                 520                 525             


Glu Ala Ser Gly Ile Gln Asp Phe Thr Lys Gln His Glu Leu Lys Gln 
    530                 535                 540                 


Leu Asp Glu Leu Val Arg Gln Gly Arg Glu Ser Ser Asn Ile Leu Pro 
545                 550                 555                 560 


Arg Tyr His Arg Val Leu Asp Arg Ala His Gly Ala Trp Asp Glu Leu 
                565                 570                 575     


Pro Lys Ser Val Lys Asp Ile Leu Lys Arg Thr Asn Leu Pro Gln Arg 
            580                 585                 590         


Arg Asn Arg Arg Glu Met Glu Lys Asn Ala Leu Trp Arg Ala Gln Tyr 
        595                 600                 605             


Val Ala Met Lys Met Val Tyr Glu Thr Ala Phe Arg Asp Trp Asp Gly 
    610                 615                 620                 


Leu Asn Asn Thr Asp Asn Leu Arg Arg Trp Arg Asp Asp Ala Ile Gln 
625                 630                 635                 640 


Arg Ala Ser Ala Gly Ala Lys Gln Ile Val Asp Pro Lys Asp Thr Arg 
                645                 650                 655     


Ile Ile Val Ser Lys Met Lys Gly Leu Ile Glu Leu Arg Asp Asn Asp 
            660                 665                 670         


Gly Leu Ala Glu Phe Asn Glu Arg Thr Ala Glu Ala Ala Ala Arg Phe 
        675                 680                 685             


Ile Glu Cys Gln Asn Asn Tyr Glu Asn Asp Glu Glu Ala Met Gln Arg 
    690                 695                 700                 


Lys Asp Ala His Ile Glu Tyr Leu Arg Leu Asp Val Ile Ala Gln Ala 
705                 710                 715                 720 


Trp Ser Glu Phe Leu Arg Ser Ser Asn Leu Gln Trp Leu Ser Tyr Ile 
                725                 730                 735     


Asp Asp Glu Arg Ser Ala Gly Arg Gln Pro Ser Ser Asp Ile Ser Ala 
            740                 745                 750         


Leu Pro Lys Ile Ala Pro Asp Thr Ser Thr Ile Pro Glu Thr His Ala 
        755                 760                 765             


Leu Leu Tyr Ala Leu Leu His Leu Met Pro Ala Tyr Thr Ala Asn Gln 
    770                 775                 780                 


Leu Val His Gln Met Arg Lys Trp Thr Val Leu Glu Thr Lys Gly Asp 
785                 790                 795                 800 


Gly Val Ala Asp Arg Asp Gln Ser Val Lys Ala Ile Ile Gly Ile Phe 
                805                 810                 815     


Asp Leu Tyr Leu Ser Met Arg Asp Ala Lys Tyr Met Gly Ser Asp Leu 
            820                 825                 830         


Val Pro Ile Thr Asn Ala Leu Ala Ser Ala Phe Asp Gly Gln Glu Val 
        835                 840                 845             


Leu Glu Arg Val Phe Pro Lys Leu Asp Pro Asp Ala Val Asp Asp His 
    850                 855                 860                 


Ile Pro Ile Arg Gly Leu Arg Glu Met Val Arg Thr Gly Ser His Glu 
865                 870                 875                 880 


Thr Leu Lys Ser Val Phe Ala Arg Val Pro Val Arg Ala Thr Gln Leu 
                885                 890                 895     


Asp Glu Leu Asp Val Lys Leu Lys Lys Leu Asp Gln Leu Tyr Thr Phe 
            900                 905                 910         


Tyr Asp Gly Leu Arg Gln Lys Trp Glu Asn Phe Lys Arg Gly Lys Pro 
        915                 920                 925             


Gly Leu Ser Asp Leu Thr Thr Glu Glu Leu Lys Gln Tyr Ala Leu Ala 
    930                 935                 940                 


Ala Glu Ser Leu Ser Gln Tyr Arg His Leu Ala Asn His Ala Tyr Leu 
945                 950                 955                 960 


Val Asp Gln Leu Ala Thr Gln Arg Val Met Met Gln Ile Phe Gly Arg 
                965                 970                 975     


Leu Ile Asp Tyr Val Gly Met Trp Glu Arg Asp Leu Tyr Phe Val Met 
            980                 985                 990         


Leu Ala Leu Ile Tyr Lys Asp Asp  Gln Thr Pro Gln Thr  Ala Trp Thr 
        995                 1000                 1005             


Asp Asp  Asn Lys Ile Glu Lys  Val Lys Thr Gly Gln  Ser Val Ala 
    1010                 1015                 1020             


Ala Ala  Arg Leu Leu Thr Gly  Gly Leu Lys Pro Gln  Leu Glu Glu 
    1025                 1030                 1035             


Ile Phe  Gly Ser Gly Phe Leu  Asp Gly Arg Gln Glu  Gly Ser Lys 
    1040                 1045                 1050             


Val Trp  Ile Arg Asn Gln Leu  Ala His Leu Asn Met  Leu Arg Ser 
    1055                 1060                 1065             


Pro Ala  Ala Thr Gln Asp Gln  Ser Ile Asn Val Thr  Thr Trp Ile 
    1070                 1075                 1080             


Asn His  Thr Arg Thr Leu Met  Ser His Asp Arg Lys  Leu Lys Asn 
    1085                 1090                 1095             


Ala Val  Ala Ser Ser Met Met  Thr Leu Met Gln Arg  Glu Asn Phe 
    1100                 1105                 1110             


Asp Leu  Arg Trp Thr Met Asn  Ala Asn His Gln Gly  Thr Thr Gln 
    1115                 1120                 1125             


<210>  872
<211>  947
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  872

Met Lys Ile Val Lys Pro Leu Gly Arg Ser Gly Thr Arg Phe Lys Ser 
1               5                   10                  15      


Asp Asp Pro Ser Gln Leu Glu Arg Ile Leu Ile Thr Thr Asp Lys Gln 
            20                  25                  30          


Asn Ile Gln His Asp His Glu Leu Asp Gln Tyr Ile Lys Thr Thr Asp 
        35                  40                  45              


Arg Ala Lys Leu Ala Gln Trp Val Ser Leu Phe Asp Lys Ile Ala Lys 
    50                  55                  60                  


Lys Pro Gln Pro Leu Lys Lys Ala Ser Ser Ile Gln Arg Glu Phe Arg 
65                  70                  75                  80  


Gln Arg Leu Trp Asp Lys Val Ser Ala Phe Leu Lys Thr Ser Gly Glu 
                85                  90                  95      


Phe Asn Asp Trp Thr Lys Val Lys Ser Ala Phe Glu Leu Lys Ile His 
            100                 105                 110         


Cys Tyr Pro Lys Asp Val Asp Thr Ser Ser Asn Ala Gly Ala Lys Gly 
        115                 120                 125             


Lys Leu Tyr Tyr Ala Phe Leu Glu Lys Gly Ala Pro Leu His Val Asp 
    130                 135                 140                 


Leu Ser Thr Ile Ala Gln Asp Met Gln Ser His Leu Asn Lys Glu Arg 
145                 150                 155                 160 


Arg Phe Ser Arg Ala Thr Lys Asp Pro Ser Ala Pro Gly Leu Ile Ser 
                165                 170                 175     


His Arg Ala Lys Ala Ile Glu Ala Asn Thr Met Arg Leu His Gly Gln 
            180                 185                 190         


Ser Arg Thr Arg Met Val Gly Gly Val Gly Val Gln Thr Asp Tyr Asp 
        195                 200                 205             


Ala Asn Asp Ile Ser Val Tyr Arg Lys Tyr Gly Asp Ile Ala Lys Thr 
    210                 215                 220                 


Ile His Asn Trp Ile Val Ala Gln Glu Asn Thr Arg Ile Lys Asp Asn 
225                 230                 235                 240 


Thr Ser Ser Pro Ile Gly Tyr Lys Asn Val Ala Asp Leu Leu Phe Thr 
                245                 250                 255     


His Tyr Gly Thr Val Phe Lys Asp Pro Ala Gly Ala Val Leu Pro Met 
            260                 265                 270         


Lys Ala Val Pro Glu Ser Arg Met Gly Glu Leu Ala Phe His Asn Ala 
        275                 280                 285             


Leu Arg Gly Phe Tyr Arg Asp Arg Leu Arg Ser His Lys Ile Ser Tyr 
    290                 295                 300                 


Asp Lys Lys His Gly Gly Thr Arg His Gln Lys Ser Leu Val His Lys 
305                 310                 315                 320 


Ile Pro His Asp Phe Asp Ser Leu Leu Lys Arg Met Gly Tyr Val Ala 
                325                 330                 335     


Asp Asn Arg Asp Ile Ala Ala Leu Ile Arg Thr Gly Lys Ala Ile His 
            340                 345                 350         


Tyr Thr Leu Ser Leu Ser Gln Asn Gly Ser Ser Gly Val Gly Tyr Thr 
        355                 360                 365             


Gln Ala Asp Trp Asp Leu Ser Thr Leu Asp Thr Ser His Phe Leu Thr 
    370                 375                 380                 


Ser Ala Gly Gln Asp Glu Ile Lys Arg Asn Glu Ala Phe Val Arg Val 
385                 390                 395                 400 


Trp Arg Gly Tyr Leu Gly Phe Ala Val Arg Thr Leu Glu Asn Trp Ile 
                405                 410                 415     


Asp Pro Lys Gly Glu His Val Gly Asp Tyr Thr Gly Arg Asp Phe Asn 
            420                 425                 430         


Ala Ala Phe Ala Asp Met Asp Glu Asn Ser Phe Asp Glu Lys Leu Arg 
        435                 440                 445             


Leu Leu Phe Gly Leu Pro Ile Asp Val Glu Asp Asn Pro Phe Gln Asn 
    450                 455                 460                 


Ala Asp Phe Ser Ile Lys Lys Ala Phe Ile Lys Lys Leu Arg Asn Asp 
465                 470                 475                 480 


Leu Arg Glu Leu Arg Asn Gln Ser Tyr His Phe Lys Ser Pro Lys Asp 
                485                 490                 495     


Phe Pro Asn Ile Ile Arg Gln Leu Gly Val Ala Pro Asn Thr Pro Thr 
            500                 505                 510         


Ser Pro Gln Ser Pro Glu Asp Gln Ala Ile Ala Gly Leu Phe Arg Asp 
        515                 520                 525             


Tyr Trp Thr Arg Asp Ile Arg Ala Gln Arg Glu Leu Leu Tyr Gln Ser 
    530                 535                 540                 


Leu Ile Gly Val His Ala Asp Tyr Tyr Leu Ser Ile Lys Thr Leu Thr 
545                 550                 555                 560 


Lys Val Tyr Lys Ala Leu Arg Asp Gly Gly Ser Asn Asp Leu Ile Leu 
                565                 570                 575     


Pro Arg Phe Asn Arg Ile Leu Gly Arg Tyr Gln Gly Ala Trp Thr Glu 
            580                 585                 590         


His Thr Leu Asn Met Lys Gly Lys Arg Leu Glu Phe Ser Met Pro Lys 
        595                 600                 605             


Lys Pro Asn Asn Ala Gln Met Glu Asn Asp Pro Ala Arg Arg Cys Gln 
    610                 615                 620                 


Tyr Val Val Leu Lys Met Leu Tyr Glu Arg Glu Phe Cys Gln Trp Leu 
625                 630                 635                 640 


Lys Ser Asp Ile Lys Pro Lys Val Leu Gln Gly Cys Val Ala Ile Ala 
                645                 650                 655     


Glu Gln Arg Ser Asp Gln Ala Ala Lys Lys Ile Lys Thr Thr Ala Ile 
            660                 665                 670         


Ala Arg Ile Val Gly Lys Phe Pro Met Gly Gln Gly Ala Thr Ile Ala 
        675                 680                 685             


Lys Leu Leu Asp Arg Ile Ser Glu Ala Met Ala Ser Glu Val Ser Val 
    690                 695                 700                 


Gln Lys His Tyr Glu Ala Asp Lys Lys Ala Ala Glu Glu Lys Ser Ala 
705                 710                 715                 720 


Phe Leu Asn Asp Phe Thr Cys Asp Ile Ile Leu Leu Ala Phe Arg Gln 
                725                 730                 735     


Phe Ile Asn Asp Lys Gly Tyr Thr Asp Ile Ile Ala Leu Asp Pro Asn 
            740                 745                 750         


Lys Pro Leu Pro Ala Gln Ala Ile Ser Arg Val Ser Pro Val Glu Arg 
        755                 760                 765             


Glu Gly Pro Gln Ala Asp Ser Ser Ala Pro Trp Gln His Ile Leu His 
    770                 775                 780                 


Val Ala Ser His Leu Val Pro Val Ser Glu Val Gly Arg Ile Arg His 
785                 790                 795                 800 


Gln Phe Arg Lys Trp Gln Ala Leu Ser Glu Lys Ile Arg Gly Gly Gly 
                805                 810                 815     


Ala Met Ala Ala Gly Met Ala Glu Ala Pro Gln Gln Phe Gln Val Pro 
            820                 825                 830         


Val Phe Ala Asp Thr Leu Leu Gln Ser Phe Asp Leu Phe Leu Asp Met 
        835                 840                 845             


His Asp Ala Lys Ala Ser Gly Gly Ala Ala Val Leu Thr Pro Arg Phe 
    850                 855                 860                 


Glu Gly Ile Leu Phe Glu Asp Arg Gly His Phe Glu Arg Leu Phe Pro 
865                 870                 875                 880 


Asp Gln Pro Gly Thr Gln Glu Glu Arg Lys Val Pro Ile Arg Gly Leu 
                885                 890                 895     


Arg Glu Ile Gln Arg Phe Gly Ser Leu Glu Pro Leu Lys His Ile Phe 
            900                 905                 910         


Glu Ser Asn Lys Val Ser Lys Glu Asp Val Ser Arg Leu Leu Ala Met 
        915                 920                 925             


Glu Arg Gln Lys Pro Ser Gly Lys Ser Arg Thr Asn His Pro Gly Ser 
    930                 935                 940                 


His Arg Leu 
945         


<210>  873
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  873

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Val Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Val 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Lys Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Met 
    690                 695                 700                 


Tyr Ile Gly Asn Asp Glu Gln Ile Asn Thr Ser Leu Ala Gly Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Lys Ile Leu Lys Tyr Thr Glu Ser Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Lys Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Leu Lys Glu Leu Lys Glu Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn Tyr Thr Met Gln Gln Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Lys Lys Asp Glu Lys Phe Asn Asp Glu Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Ile Met Lys Ser  Val Val Asn Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Lys Phe Lys  Ile Gly Ala Asp Asn  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Lys Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Glu  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  874
<211>  1184
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  874

Met Arg Val Ser Lys Val Lys Val Leu Gly Asn Glu Glu Thr Lys Gly 
1               5                   10                  15      


Arg Ile Val Leu Met His Arg Ser Pro Val Lys Gly Gln Leu Ile Tyr 
            20                  25                  30          


Ser Glu Asp Ala Gly Lys Arg Asp Arg Thr Glu Asp Ile Ile Pro Glu 
        35                  40                  45              


Gln Lys Leu Glu Ser Phe His Leu Ser Ile Leu Asn Lys Thr Phe Leu 
    50                  55                  60                  


Arg Lys Glu Phe Phe Lys Lys Glu Leu Lys His Glu Ala Lys Lys Asn 
65                  70                  75                  80  


Gly Leu Lys Gly Asp Ala Glu Asp Lys Tyr Ile Ser Glu Lys Leu Lys 
                85                  90                  95      


Glu Tyr His Ser Leu Leu Gln Phe Ile Asp Asp Val Leu Ser Val Lys 
            100                 105                 110         


Tyr Asn Glu Asn Arg Lys Ala Ile Lys Phe Pro Glu Tyr Leu Thr Arg 
        115                 120                 125             


Glu Met Ile Glu Ile Phe Leu Asn His Lys Phe Arg Lys Glu Val Thr 
    130                 135                 140                 


Tyr Thr Asn Lys Asn Gly Ala Ser Val Ser Phe Leu Leu Ser Thr Leu 
145                 150                 155                 160 


Ile Leu Asn Ala Ile Glu Lys His Ser Val Ile Glu Met Gln Pro Phe 
                165                 170                 175     


Val Asp Trp Arg Asn Trp Phe Val Glu Thr Lys Ser Lys Phe Leu Lys 
            180                 185                 190         


Lys Ser Ile Ile Asn Asn Cys Ile Pro Thr Asn Gly Gly Pro Ile Ser 
        195                 200                 205             


Arg Arg Arg Glu Thr Leu Met Lys Trp Arg Asp Asp Tyr Phe Thr Asn 
    210                 215                 220                 


Ala Glu Ile Asp Leu Ala Arg Leu His Lys Lys Phe Gly Thr Asp Thr 
225                 230                 235                 240 


Leu Met Ala Ser Leu Arg Glu Val Pro Gln Thr Glu Lys Ser Gly Asn 
                245                 250                 255     


Glu Tyr His Arg Leu Leu Lys Ser Cys Leu Gln Ser His Gln Lys Lys 
            260                 265                 270         


Leu Phe Gly Lys Arg Ala Glu Gly Tyr Asp Ile Asn Arg Ala Asp Asn 
        275                 280                 285             


Gln Leu Tyr Val Tyr Asn Thr Glu Val Val Lys Tyr Met Glu His Tyr 
    290                 295                 300                 


Phe Pro Val Lys Ser Ser Lys Arg Arg Asn Ser Thr Ala Glu Ile Lys 
305                 310                 315                 320 


Tyr Tyr Leu Gln Thr Asp Thr Ile Lys Cys Cys Leu His His Gln Ile 
                325                 330                 335     


Ile Asn Ala Val Arg Gly Leu Ala Leu Arg Glu Gly Lys Phe Asn Leu 
            340                 345                 350         


His Gly Phe Asp Asp Lys Leu Ile Pro Asn Glu Arg Asn Val Ser Ser 
        355                 360                 365             


Ser Ile Leu Asn Glu Leu Lys Thr Ser Glu Gly Phe Val Leu Asn Met 
    370                 375                 380                 


Leu Gly Gly Cys Ala Phe Ala Ala Asn Cys Leu Arg Asn Ile Val Asp 
385                 390                 395                 400 


Ala Thr Gln Arg Ser Asp Leu Leu Gly Phe Arg Cys Phe Glu Val Ser 
                405                 410                 415     


Leu Lys Lys Gly Lys Ser Asn Ser Asp Leu Phe Ala Leu Phe Phe Gly 
            420                 425                 430         


Phe Gly Arg Glu Asp Met Asp Asp Asp Ser Glu Trp Glu Lys His Leu 
        435                 440                 445             


Tyr Ala Ala Arg Tyr Ser Val Ser Glu Ile Arg Asn Arg Val Ala His 
    450                 455                 460                 


Tyr His Lys Ser Ala Ile Glu Asn Ile Tyr Asn Ile Thr Asp Phe Glu 
465                 470                 475                 480 


Tyr Arg Glu Asn Ser Met Cys Ser Tyr Thr Asp Thr Lys Phe Thr Thr 
                485                 490                 495     


Ala Leu Gln Asn Glu Ile Tyr Asn Thr Pro Lys Ala Phe Ser Leu Gln 
            500                 505                 510         


Leu Met Thr Gly Lys Val Leu Glu Tyr Tyr Pro Lys Glu Lys Leu Val 
        515                 520                 525             


Ser Phe Phe Gln Lys Tyr Lys Phe Ser Leu Tyr Arg Ser Val Val Pro 
    530                 535                 540                 


Phe Ala Pro Gly Phe Lys Asn Ile Met Arg Thr Gly Val Asn Tyr Gln 
545                 550                 555                 560 


Asn Ala Thr Gln Asn Arg Leu Phe Tyr Asp Met Gly Leu Thr Ala Phe 
                565                 570                 575     


Gln Asp Lys Asp Arg Tyr Ile Asp Asp Val Glu Ala Trp Asn Ala Arg 
            580                 585                 590         


Tyr Phe Phe Met Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Arg Phe 
        595                 600                 605             


Thr Asn Asp Lys Asn Asp Leu Phe Arg Lys Thr Val Glu Gln Val Leu 
    610                 615                 620                 


Glu Val Asn Arg Ser His Met Glu Lys Val Gly Lys Asp Asp Arg Gln 
625                 630                 635                 640 


Ala Phe Gly Glu Val Arg Gln Met Arg Glu Asn Glu Thr Ala Asn Asp 
                645                 650                 655     


Tyr Met Ala Tyr Leu Gln Ser Ser Leu Arg Met Glu Lys Asn Lys Lys 
            660                 665                 670         


Glu Leu Glu Gly Asn Gly Ala Lys Arg Ile Asn Phe Glu Lys Phe Ile 
        675                 680                 685             


Leu Gln Met Phe Val Lys Gly Phe Asp Ser Phe Leu Lys Asp Gly Ala 
    690                 695                 700                 


Phe Glu Phe Val His Ser Pro Glu Asn Cys Leu Thr Gly Ser Thr Glu 
705                 710                 715                 720 


Lys Glu Arg Ala Lys Glu Arg Asn Ser Leu Cys Glu Glu Ile Gly Asn 
                725                 730                 735     


Tyr Val Arg Leu Val Ser Thr Val Ile Asp Pro Gly Lys Gly Ser His 
            740                 745                 750         


Val Ala Phe Tyr Val Phe Cys Lys Met Leu Asn Ser Val Tyr Leu Ser 
        755                 760                 765             


Asn Ile Arg Asn Glu Met Ile Lys Tyr His Lys Val Val Arg Thr Asp 
    770                 775                 780                 


Glu Leu Ala His Leu Ile Glu Ile Ile Glu Leu Cys Leu Leu Ser Ala 
785                 790                 795                 800 


Asp Ala Val Ser Gln Lys Thr Val Asn Ala Asp Lys Leu Ser His Phe 
                805                 810                 815     


Phe Ala Glu Gly Val Asn Val Asp Asp Asp Glu Asn Val Ile His Ala 
            820                 825                 830         


Ser Met Glu Thr Phe Arg Lys Tyr Gly Thr Arg Asp Leu Phe His Lys 
        835                 840                 845             


Leu Met Leu Gln Asp Asp Arg Phe Leu Val Ser Ser Asp Asp Tyr Arg 
    850                 855                 860                 


Glu Trp Glu Glu Met Lys Glu Lys Ile Glu Gly Lys Val Lys Gln Arg 
865                 870                 875                 880 


Glu Leu Leu His Ala Glu Trp Cys Glu Ala Lys Glu Lys Asp Lys Lys 
                885                 890                 895     


Ser Arg Lys Val Lys Ser Asn Ser Arg Thr Cys Phe Glu Lys Lys Phe 
            900                 905                 910         


Met Gly Ala Lys Ala Glu Glu Tyr Tyr Ser Leu Cys Asn Val Ile Asp 
        915                 920                 925             


Lys Tyr Asn Trp Leu Asp Asn Lys Leu His Leu Val His Leu Asn Lys 
    930                 935                 940                 


Leu His Asn Leu Val Ile Glu Ile Leu Gly Arg Met Val Gly Phe Thr 
945                 950                 955                 960 


Ala Leu Phe Glu Arg Asp Phe Gln Tyr Ile Cys Lys Ser Asp Ser Glu 
                965                 970                 975     


Tyr Glu Gln Leu Tyr Asn Leu Asp Phe Asn Met Gly Leu Pro Lys Phe 
            980                 985                 990         


Lys Asn Ser Ile Lys Gly Ser Gly  Lys Ala Lys Asn Ser  Thr Gln Asn 
        995                 1000                 1005             


Ile Asp  His Asn Ala Thr Gly  Ile Gly Asn Ser Ser  Asn Leu Leu 
    1010                 1015                 1020             


Lys Glu  Asn Ser Asn Gly Thr  His Tyr Cys Lys Asn  Leu Ser Gly 
    1025                 1030                 1035             


Asp Gly  Val Glu Asp Lys Leu  Lys Arg Leu Phe Leu  Tyr Asp Asp 
    1040                 1045                 1050             


Tyr Arg  Asn Val Arg Asn Phe  Val Ala His Phe Asn  Tyr Leu Thr 
    1055                 1060                 1065             


Arg Val  Glu Asp Asp Leu Gly  Gly Asn Asp Ala Val  Lys Leu Ser 
    1070                 1075                 1080             


Gly Thr  Arg Tyr Ser Leu Ile  Glu Leu Ile Asn Glu  Leu Arg Asn 
    1085                 1090                 1095             


Leu Leu  Lys Tyr Asp Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ser 
    1100                 1105                 1110             


Phe Ile  Asp Met Phe Glu Arg  His Gly Met His Val  Lys Met Lys 
    1115                 1120                 1125             


Leu Asn  His Asn His Lys Leu  Phe Val Asp Ser Ile  Ser Pro Arg 
    1130                 1135                 1140             


Lys Ile  Lys His Leu Gly Gly  Gly Tyr Lys Lys Arg  Gly Lys Asp 
    1145                 1150                 1155             


Asp Lys  Met Tyr Val Gln Thr  Thr Asn His Val Asp  Pro Leu Tyr 
    1160                 1165                 1170             


Cys Asp  Met Cys Arg Ala Leu  Leu Glu Met Lys 
    1175                 1180                 


<210>  875
<211>  1228
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  875

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr 
    1220                 1225             


<210>  876
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  876

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Lys Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Leu Tyr Gln Ile Val  Ser Ala Phe Asn Phe  Gly Ser Lys 
    1205                 1210                 1215             


Leu Leu  Tyr Ile Ser Glu Asp  Gly Arg Trp Lys Met  Ala Gly Gly 
    1220                 1225                 1230             


Ala Phe  Pro Gly Lys Tyr Gly  Arg Phe Glu Asn Asp  Tyr Asn His 
    1235                 1240                 1245             


Arg Thr  Ser Leu Ser Lys Val  Ile Arg Leu Phe Glu  Asn Glu Ser 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ile Ile Tyr  Trp Arg Asp Tyr Val  Asp His Met 
    1265                 1270                 1275             


Lys Tyr  Tyr Val Asn Gln Asn  Gln Ser Ile Met Glu  Ile Tyr Ser 
    1280                 1285                 1290             


Ala Phe  Tyr Ser Lys Val Leu  Gly Tyr Ser Ala Lys  Leu Arg Lys 
    1295                 1300                 1305             


Ser Val  Val Phe Asn Leu Gln  Ala Ala Leu Glu Lys  His His Ile 
    1310                 1315                 1320             


Asn Pro  Glu Cys Ile Trp Met  Thr Ser Asp Gly Lys  Cys Ala Asp 
    1325                 1330                 1335             


Ile Lys  Leu Met Lys Asn Leu  Glu Ser Gln Lys Phe  Thr Tyr Lys 
    1340                 1345                 1350             


Leu Ala  Lys Arg Glu Gly Glu  Lys Thr Glu Arg Lys  Ile Cys Met 
    1355                 1360                 1365             


Asn Ala  Leu Asn Glu Asn Phe  Leu Lys Thr Ile Arg  Thr Ser Leu 
    1370                 1375                 1380             


Glu Tyr  Lys Lys 
    1385         


<210>  877
<211>  1432
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  877

Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser Val Thr 
1               5                   10                  15      


Glu Asn Lys Asn Glu Glu Gln Leu Ser Arg Gln Ser Leu Leu Tyr Tyr 
            20                  25                  30          


Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp Leu Glu 
        35                  40                  45              


Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr Asn Val 
    50                  55                  60                  


Ile Thr Pro Glu Ile Asp Leu Cys Lys Glu Glu Asn Arg Glu Trp Ile 
65                  70                  75                  80  


Val Glu Asp Leu Thr Lys Asn Phe Asn Ala Val Ile Asn Asn Ala Leu 
                85                  90                  95      


Arg Ser Ile Lys Asn Pro Lys Glu Lys Arg Glu Glu Arg Val Glu Lys 
            100                 105                 110         


Glu Val Ala Phe Ile Leu Asn Leu Asn Lys Asn Ser Ile Lys Ile Lys 
        115                 120                 125             


Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe Ser Ala 
    130                 135                 140                 


Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser Lys Glu 
145                 150                 155                 160 


Glu Ala Tyr Ile Arg Glu Met Ile Ser Asn Leu Val Leu Arg Lys Leu 
                165                 170                 175     


Lys Lys Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Cys Lys Met 
            180                 185                 190         


Gln Met Thr Glu Ile Thr Ile Ser Leu Met Ser Ala Ile Cys Leu Tyr 
        195                 200                 205             


Gly Asn Val Glu Ser Phe Asp Pro Val Ile Leu Lys Ala Phe Phe Glu 
    210                 215                 220                 


Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile Val 
225                 230                 235                 240 


Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys Asp 
                245                 250                 255     


Gly Lys His Leu Leu Ile Pro Ala Asn Ala Asp His Arg Lys Lys Lys 
            260                 265                 270         


Tyr Val Phe Glu Phe Met Arg Lys Tyr Ala Ala Ala Glu Glu Lys Glu 
        275                 280                 285             


Lys Arg Glu Ile Thr Glu His Ile Gln Asn Leu Ile Gly Leu Tyr Leu 
    290                 295                 300                 


Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asn Met 
305                 310                 315                 320 


Thr Glu Ser His Asn Cys Ile Ser Gly Glu Ile Glu Glu Ile Phe Asn 
                325                 330                 335     


Glu Ile Glu Glu Leu Glu Asn Ser Ser Lys Gln Lys Arg Glu Glu Lys 
            340                 345                 350         


Lys Lys Thr Arg Glu Glu Leu Asp Lys Ile Gln Glu Ser Arg Lys Gly 
        355                 360                 365             


Asn Lys Arg Asn Thr Asn Ser Asn Asn Gln Asn Tyr Lys Asn Asn Lys 
    370                 375                 380                 


Thr Asp Ser Asp Lys Lys Glu Asn Gln Ala Asp Ala Asn Glu Asn Lys 
385                 390                 395                 400 


Leu Lys Glu Asn Glu Leu Arg Asp Lys Arg Arg Arg Leu Ser Lys Glu 
                405                 410                 415     


Leu Glu Asn Leu Asp Ser Glu Val Arg Ile Lys Lys Glu Lys Leu Lys 
            420                 425                 430         


Asn Thr Thr Val Lys Glu Met Ala Leu Lys Tyr Arg Ala Ala Val Asn 
        435                 440                 445             


Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile Lys Glu 
    450                 455                 460                 


Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr Ile Asp 
465                 470                 475                 480 


Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp Arg Tyr 
                485                 490                 495     


Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu Trp Thr 
            500                 505                 510         


Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val Tyr His 
        515                 520                 525             


Phe Ala Ile Pro Asp Leu Ser Gly Ala Leu Glu Gly Glu Ser Val Ser 
    530                 535                 540                 


Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly Phe Asp 
545                 550                 555                 560 


Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met Glu Lys 
                565                 570                 575     


Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr Pro Glu 
            580                 585                 590         


Glu Glu Arg Glu Lys Pro Gly His Glu Asp Val Leu Leu Met Lys Thr 
        595                 600                 605             


Leu Ser Glu Ile Glu Glu Ser Gln Thr Glu Glu Glu Arg Gln Lys Lys 
    610                 615                 620                 


His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp Ala Asp 
625                 630                 635                 640 


Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg Lys Lys 
                645                 650                 655     


Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr Lys Glu 
            660                 665                 670         


Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His Tyr Thr 
        675                 680                 685             


Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Glu Leu Thr Glu Tyr 
    690                 695                 700                 


Phe Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg Glu Lys 
705                 710                 715                 720 


Tyr Tyr Thr Asn Asn Val Trp Lys Tyr Tyr Asp Ile Glu Val Ile Asn 
                725                 730                 735     


Asn Ile Met Gly Lys Ile Tyr Cys Gly Arg Lys Tyr Arg Ala Ala Gln 
            740                 745                 750         


Val Pro Ala Phe Asn Asn Ile Ile Ser Arg Pro Ala Leu Pro Gln Leu 
        755                 760                 765             


Met Asp Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met Asn Cys 
    770                 775                 780                 


Pro Asp Arg Asp Val Ile Lys Lys Tyr Trp Ser Ser Leu Phe Phe Val 
785                 790                 795                 800 


Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Glu Lys Pro 
                805                 810                 815     


Glu Asp Asn Ile Lys Glu Arg Phe Phe Arg Ala Met Glu Lys Glu Ser 
            820                 825                 830         


Gly Gln Ala Lys Asp Gly Lys Glu Gln Lys Ala Trp Glu Ser Phe Glu 
        835                 840                 845             


Asn Arg Ile Asp Gln Ile Gly Arg Glu Arg Ser Phe Gly Ala Ile Cys 
    850                 855                 860                 


Gln Gly Leu Met Val Glu Tyr Met Leu Gln Asn Arg Asp Ile Ser Met 
865                 870                 875                 880 


Val Gln Thr Glu Thr Gly Asp Gly Lys Thr Asn Lys Lys Gln Ile Tyr 
                885                 890                 895     


Lys His Tyr Arg Thr Leu Leu Tyr Ile Cys Ile Arg Ser Ala Phe Thr 
            900                 905                 910         


Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro Val Leu Thr 
        915                 920                 925             


Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Gln Thr Asp Gly Leu Lys 
    930                 935                 940                 


His Leu Ser Leu Phe Asp His Leu Lys Glu Thr Phe Asn Asp Ala Glu 
945                 950                 955                 960 


Ser Gly Ser Phe Trp Tyr Met Ala Ala His Phe Ile Asn Gln Lys Tyr 
                965                 970                 975     


Leu Asn His Leu Ile Gly Ser Ile Arg Asn Tyr Leu Gln Phe Thr Glu 
            980                 985                 990         


Asp Ile Glu Asp Arg Ala Leu Ser  Leu Gly Asp Cys Val  Asp Asn Lys 
        995                 1000                 1005             


Arg Glu  Glu Lys Asn Leu Arg  Tyr Arg Asn Thr Leu  Glu Ile Leu 
    1010                 1015                 1020             


Glu Phe  Val Ala Gln Phe Cys  Glu Arg Thr Thr Asn  Val Met Glu 
    1025                 1030                 1035             


Asp Tyr  Phe Glu Ser Asn Gln  Glu Tyr Ala Ala Tyr  Leu Ser Gly 
    1040                 1045                 1050             


Phe Val  Asp Tyr Asn Val Ser  Lys Lys Glu Thr Asp  Ile Glu Lys 
    1055                 1060                 1065             


Ala Leu  Tyr Gly Phe Cys Arg  Gln Lys Phe Lys Val  Asp Gly Lys 
    1070                 1075                 1080             


Glu Tyr  Met Ala Gly Ile Tyr  Tyr Asp Gly Glu Asn  Leu Ile Pro 
    1085                 1090                 1095             


Asn Arg  Asn Ile Ile Arg Ala  Asn Met Tyr Gly Asn  Val Ser Cys 
    1100                 1105                 1110             


Leu Lys  Pro Tyr Met Asp Arg  Ile Thr Leu Lys Glu  Ile Arg Thr 
    1115                 1120                 1125             


Met Tyr  Ala Asp Gln Asn Lys  Leu Asp Thr Val Leu  Lys Glu Gly 
    1130                 1135                 1140             


Val Cys  Arg Thr Glu Glu Glu  Gln Lys Ala Tyr Arg  Glu Tyr Gln 
    1145                 1150                 1155             


Asn Glu  Lys Asn Arg Ile Glu  Leu Phe Asp Leu Cys  Thr Tyr Thr 
    1160                 1165                 1170             


Gln Ile  Leu Asn Asp Ile Gln  Ala Lys Leu Ile Gly  Trp Ser Tyr 
    1175                 1180                 1185             


Met Arg  Glu Arg Asp Leu Met  Tyr Tyr Gln Leu Gly  Tyr Tyr Tyr 
    1190                 1195                 1200             


Thr Lys  Leu Phe Trp Thr Asp  Ser Ile Ser Glu Glu  Asp Ala Arg 
    1205                 1210                 1215             


Arg Arg  Leu Met Gly Glu Leu  Val Asn Val Glu Asp  Gly Val Ile 
    1220                 1225                 1230             


Leu Tyr  Gln Ile Leu Ala Phe  Asn Ser Tyr Asn Leu  Pro Ile Ile 
    1235                 1240                 1245             


Ala Asn  Lys Asn Asn Thr Val  Thr Phe Leu Lys Gly  Glu Gly Ser 
    1250                 1255                 1260             


Ile Gly  Gly Lys Ala Ile Thr  Ala Phe Leu Lys Asn  Tyr Glu Asn 
    1265                 1270                 1275             


Ala Glu  Arg Ile Tyr Glu Glu  Ala Leu Asp Leu Phe  Glu Asn Thr 
    1280                 1285                 1290             


Asp Glu  His Ala Ala Ile Ile  Asn Thr Arg Asn Tyr  Ile Glu His 
    1295                 1300                 1305             


Phe Lys  Tyr Phe Ile Lys Ser  Asp Arg Ser Met Met  Asp Leu Tyr 
    1310                 1315                 1320             


Ser Glu  Val Tyr Asp Arg Phe  Phe Arg His Asp His  Asn Arg Lys 
    1325                 1330                 1335             


Lys Asn  Val Pro Asp Ser Leu  Lys Asn Val Leu Ala  Asp Asn Phe 
    1340                 1345                 1350             


Met Ile  Ala Asp Ile Ser Met  Glu Leu Gly Ser Lys  Lys Val Gly 
    1355                 1360                 1365             


Glu Lys  Lys Lys Gly Phe Arg  Glu His Lys Ala Ala  Arg Ile Glu 
    1370                 1375                 1380             


Phe Thr  Asp Arg Gly Ile Arg  Ser Thr Asp Met Thr  Tyr Thr Val 
    1385                 1390                 1395             


Lys Pro  Asp Pro Lys Asp Ser  Lys Lys Asp Glu Lys  Val Leu Val 
    1400                 1405                 1410             


Pro Ala  Arg Ser Glu Val Phe  Leu Lys Gln Phe Gln  Lys Ile Leu 
    1415                 1420                 1425             


Glu Tyr  Arg Ile 
    1430         


<210>  878
<211>  1104
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  878

Met Arg Ile Val Lys Pro His Gly Thr Ser Glu Thr His Phe Asp Lys 
1               5                   10                  15      


Glu Gly Arg Ile Arg Arg Tyr Val His Ser Asp Ser Phe Pro Cys Glu 
            20                  25                  30          


Pro Leu Glu Pro Lys Glu Phe Ala Thr Arg His Pro Lys Leu Val Ile 
        35                  40                  45              


Ala Gln Trp Val Ser Cys Ile Asp Lys Val Ile Thr Arg Pro His Gly 
    50                  55                  60                  


Asp Gly Leu Pro Ser Glu Thr Gln Trp Ser Leu Arg Asn Gly Leu Gly 
65                  70                  75                  80  


Lys Ala Ala Trp Asp Leu Ile Val Glu Arg Gly Leu Leu Asp Ala Pro 
                85                  90                  95      


Glu Lys Arg Leu Lys Arg Phe Glu Arg Gln Trp Trp Ala Arg Ile His 
            100                 105                 110         


Pro Tyr Gly Asn Glu Thr Asp Ala Asn Thr Pro Arg Asn Pro Tyr Gly 
        115                 120                 125             


His Trp Tyr Arg Ser Leu Ala Gly Gly Val Asp Ile Ala Glu Phe Asp 
    130                 135                 140                 


Pro Ala Thr Val Ala Asn Met Ile Tyr Ala His Leu Tyr Glu Asn Ala 
145                 150                 155                 160 


Ser Arg Thr His Pro Glu His Gly Pro Arg Arg Ser Gly Leu Ile Pro 
                165                 170                 175     


Glu Arg Ser Glu Ser Ile Ala Lys Ser Val Pro Ala Arg Thr Ala Pro 
            180                 185                 190         


Gly Gly Gly Arg Leu Ser Pro Pro Trp Asp Ala Ser Asp Gly Ala Ile 
        195                 200                 205             


Tyr Leu Glu Ala Gly Asp Val Ala Ala Thr Met Leu Glu Arg Leu Glu 
    210                 215                 220                 


Lys His Phe Gly Glu Arg His Ala Lys Leu Arg Arg Ile Cys Ala Ala 
225                 230                 235                 240 


Thr Leu Ala Glu His Leu Thr Arg Leu Arg Arg Glu Val Leu His Ile 
                245                 250                 255     


Ser Asp Gly Asp Arg Leu Pro Glu Ser Leu Tyr Gln Leu His Glu Gln 
            260                 265                 270         


Val Arg Arg Ser Tyr Ser Asp Ile Leu Lys Gly Asp Gln Arg Tyr Leu 
        275                 280                 285             


Ser Lys Lys Leu Pro Ser Ser Gly Asp Gln Leu Val Ser Leu Val Glu 
    290                 295                 300                 


Ser Lys Arg Leu Asn Arg Glu Val Ala Ala Leu Ile Arg Leu Gly Arg 
305                 310                 315                 320 


Val Ile His Tyr Glu Ser Thr Ala Glu Asn Gly Pro Ser His Thr Ser 
                325                 330                 335     


Asn Val Leu Asp His Trp Pro Ser Gln Thr Asp Ser Ser Arg Phe Trp 
            340                 345                 350         


Leu Ser Ala Gly Gln Thr Glu Ile Lys Arg Asn Glu Ala Phe Val Arg 
        355                 360                 365             


Ile Trp Arg Gly Ile Leu Ala Arg Ala Ala Arg Thr Ala Thr Asp Trp 
    370                 375                 380                 


Ala Asp Pro Glu Arg Ala Ile Pro Arg Asp Val Leu Gly Ala Lys Gln 
385                 390                 395                 400 


Leu Ser Glu Ala Val Thr Asn Ile Thr Asp Thr Ala Phe Asp Arg Lys 
                405                 410                 415     


Ala Lys Leu Leu Phe Gly Asn Arg Ser Asp Leu Leu Thr Ser Leu Pro 
            420                 425                 430         


Leu Glu Arg Lys Arg Gln Val Leu Asp Leu Ala Leu Arg Gly Leu Gly 
        435                 440                 445             


Gln Leu Arg Asn Asn Ala Phe His Phe Val Gly Leu Glu Ala Phe Leu 
    450                 455                 460                 


Ala Ser Leu Arg Gly Leu Asp Gly Ile Ala Asp Ala Asp Thr Arg Thr 
465                 470                 475                 480 


Val Leu Asp His Ile Trp Arg Asp Asp Thr Lys Asp Arg Asn Thr Arg 
                485                 490                 495     


Leu Val Gln Thr Ile Arg Ala Ser Asn Ala Pro Ala Tyr Phe Ser Arg 
            500                 505                 510         


Gln Glu Met Glu Gly Phe Val Ser Ser Ile Ala Arg Thr Pro Ala Val 
        515                 520                 525             


Phe Leu Glu Leu Pro Ala Phe Gly Arg Ile Leu Arg Arg Ala Ser Val 
    530                 535                 540                 


Ala Trp Thr Ile Asp Arg Tyr Arg Leu Thr Leu Pro Ala Pro Lys Ala 
545                 550                 555                 560 


Val Gly Glu Pro Val Ala Ala Glu Cys Gln Arg Val Cys Leu Gly Leu 
                565                 570                 575     


Ile Tyr Asp Arg Ala Phe Gly Asp Trp Leu Gln Val Leu Glu Thr Glu 
            580                 585                 590         


Arg Leu Arg Asp Cys Val Asp Arg Ala Val Thr Arg Ala Ser Val Glu 
        595                 600                 605             


Ala Arg Arg Val Thr Arg Asp Asp Thr Val Asn Ala Arg Thr Ile Gly 
    610                 615                 620                 


Lys Phe Lys Ile Thr Gln Gly Asp Thr Leu Glu Ser Phe Phe Ser Arg 
625                 630                 635                 640 


Leu Thr Ala Ala Val Thr Arg Glu Leu Arg Gln Thr Asp Ala Arg Lys 
                645                 650                 655     


Gln Thr Lys Arg Ala Ala Ser Lys His Leu Asp Asp Leu Arg Cys Asp 
            660                 665                 670         


Val Val Ala Gln Leu Phe Glu Ile Tyr Leu Lys Glu Ala Asp Leu Gly 
        675                 680                 685             


Trp Leu Leu Ser Gly Phe Gln Thr Arg Lys Pro Thr Gly Ala Ser Lys 
    690                 695                 700                 


Thr Asp Ala Ala Phe Cys Pro Pro Pro Ser Ser Ala Gln Thr Phe Gln 
705                 710                 715                 720 


Ala Trp Glu Pro Ile Leu Tyr Phe Ile Leu His Leu Val Pro Val Asp 
                725                 730                 735     


Thr Thr Thr Arg Leu Ala His Gln Val Gly Arg Phe Arg Asp Gly Gly 
            740                 745                 750         


Gln Ile Asp Thr Gly Leu Ile Glu Gly Leu Gln Arg Thr Leu Asp Leu 
        755                 760                 765             


Tyr Arg Val Met His Asp Ala Lys Phe Ala Gly Ala Ala Ser Gly Leu 
    770                 775                 780                 


Arg Pro Asp Glu Met Arg Ser Ile Leu Leu Lys Thr Gly Leu Tyr Ser 
785                 790                 795                 800 


Gly Ala Thr Glu Gly Thr Glu Leu Ala Phe Glu Thr Arg Gly Leu Arg 
                805                 810                 815     


Glu Phe Phe Arg Phe Gly Asp His His Leu Phe Thr Thr Asp Phe Ala 
            820                 825                 830         


Gln Asn Pro Val Thr Arg Asp Gln Phe His Glu Ile Lys Ser Leu Arg 
        835                 840                 845             


Ala Asp Leu Ala Leu Ala Gln Asp Arg Arg Ser Ala Leu His Ala Glu 
    850                 855                 860                 


Trp Val Ser Asn Gly Lys Ala Leu Ser Gly Ala Lys His Asp Glu Tyr 
865                 870                 875                 880 


Arg Ala Leu Leu Asn Arg Ile Glu Arg Gly Arg His Leu Ser Asp His 
                885                 890                 895     


Ala Glu Leu Arg Asp His Leu Arg Leu His Gly Ile Leu Ile Asp Val 
            900                 905                 910         


Leu Ala Arg Leu Leu Asp Phe Ala Gly Gln Trp Glu Arg Asp Leu Tyr 
        915                 920                 925             


Phe Thr Thr Leu Ala Leu Ile His Leu Ala Gly Thr Thr Pro Gln Asp 
    930                 935                 940                 


Ala Phe Asp Asp Arg Arg Gly Trp His Ala Val Arg Thr Gly Gln Ile 
945                 950                 955                 960 


Leu Ala Ala Leu Arg Ser Thr Arg Asp Thr Pro Glu Met Gln Asp Ile 
                965                 970                 975     


Leu Ala Lys Leu Ala Met Val Phe Asn Ile Asp Met Pro Gly Val Arg 
            980                 985                 990         


Gly Ala Asn Val Arg Thr Arg Asn  Asp Leu Ala His Phe  Asn Cys Leu 
        995                 1000                 1005             


His Thr  Pro Ala Ala Ser Ile  Asp Leu Thr Ala Leu  Ile Asn Arg 
    1010                 1015                 1020             


Thr Arg  Ala Leu Met His Tyr  Asp Arg Lys Gln Glu  Asn Ala Val 
    1025                 1030                 1035             


Ser Lys  Ser Val Ile Glu Leu  Leu Asp Arg His Lys  Leu Val Leu 
    1040                 1045                 1050             


Ser Trp  Thr Phe Ser Gly Gly  Gln Leu Gly Lys Ser  Thr Val Arg 
    1055                 1060                 1065             


Pro Lys  Val Ile Arg His Leu  Glu Gln Pro Glu Val  Lys Glu Cys 
    1070                 1075                 1080             


Leu Val  Ser Thr Ala Phe Ser  Ala Ala Val Gly Arg  Leu Phe Gly 
    1085                 1090                 1095             


Ala Thr  Glu Lys Asp Gly 
    1100                 


<210>  879
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  879

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  880
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  880

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Gly Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  881
<211>  1373
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  881

Met Ala Lys His Leu Arg Pro Ile Gly Glu Ser Tyr Thr Asp Phe Leu 
1               5                   10                  15      


Asp Glu Thr Glu Phe Val Arg Leu Gly Arg Gly Leu His Arg Gly His 
            20                  25                  30          


His Gly Val Gln Ile Pro Pro Thr Glu Leu Pro Ser Tyr Leu Ala Glu 
        35                  40                  45              


Tyr Arg Lys Ala Leu Met Arg Gln Val Val Ala Val Leu Asp Lys Val 
    50                  55                  60                  


Val Gly Lys Arg Arg Arg Leu Ser Gly Met His Pro Glu Ala Tyr Arg 
65                  70                  75                  80  


Asp Arg Val His Leu Ala Glu Ala Leu Trp Val Arg Leu Val Ala Arg 
                85                  90                  95      


Val Lys Glu Ile Gly Thr Pro Pro Asp Pro Ser Glu Leu Leu Asp Leu 
            100                 105                 110         


Arg Arg Met Trp Asn Ala Lys Ala His Pro Tyr Ala Glu Tyr Asp Val 
        115                 120                 125             


Val Pro Arg Ala Pro Leu Asn Asp Gly Asn Gly Gln Lys Ile Leu Glu 
    130                 135                 140                 


Cys Arg Glu Val Asp Asp Pro Lys Ile Glu Arg Ser Asp Phe Glu Gly 
145                 150                 155                 160 


Arg Trp His Gly Arg Phe Trp Gln Ser Glu Pro Gly Pro Val Asp Tyr 
                165                 170                 175     


Asn Ala Ile Ala Asp Arg Ile Phe Ala His Leu Phe Asp Gln Glu Ala 
            180                 185                 190         


Val Ile Gly Gly Gly Pro Arg Arg Glu Gly Asn Val Thr Val Pro Asp 
        195                 200                 205             


Glu Asp Ile Asn Gly Gln Pro Gly Pro Ala Thr Gly Lys Gly Leu Ile 
    210                 215                 220                 


Ile Ala Arg Gly Gln Ser Ile Val Lys Ser Ala Ser Asp Pro Arg Arg 
225                 230                 235                 240 


Ser Ser Lys Lys Val Gln Arg Thr Trp Asp Lys Ala Val Glu Arg Arg 
                245                 250                 255     


Tyr Phe Gly Asp Asp Gly Lys Gly Gly Ser Asp Ile Ala Lys Ala Ile 
            260                 265                 270         


Tyr Glu Glu Leu Gly Asp Pro Ala Thr Leu Ala Asp Pro Ile Tyr Ala 
        275                 280                 285             


Ser Trp Phe Gly Ser Arg Leu Tyr Asp His Phe Gly Ser Phe Lys Asn 
    290                 295                 300                 


Ser Leu Pro Leu Glu Leu Lys Asp Pro Phe Lys Glu Gln Ile Trp Ala 
305                 310                 315                 320 


Leu His Asn Ser Val Arg Gln Phe Tyr Gln Arg Met Ala Lys Ser Asp 
                325                 330                 335     


Arg Phe Arg Leu Ala Leu Gln Asn Ala Arg Ser Glu Val Pro Asp Arg 
            340                 345                 350         


Ser Glu Leu Leu Ala Leu Leu Pro Lys Asp His Asp His Leu Leu Leu 
        355                 360                 365             


Val Leu Gly Gly Lys Lys Lys Asn Ala Glu Met Ser Glu Leu Ile Arg 
    370                 375                 380                 


Leu Gly Lys Leu Phe Val His Ala Ser Asp Val Leu His Asp Phe Asp 
385                 390                 395                 400 


Ala Asn Asp Ala Ala Ala Leu Asp Ala Phe Lys Arg Arg Met Ser Phe 
                405                 410                 415     


Leu Ala Thr Ser Ile Gly Gln Ser Glu Ile Lys Gln Thr Glu Thr Phe 
            420                 425                 430         


Ala Arg Thr Trp Arg Gly Ala Val Gly Leu Thr Leu Arg Thr Val Lys 
        435                 440                 445             


Gly Leu Ala Asp Pro Arg Gly Ile Ile Gly Thr Pro Asp Asn Arg Asp 
    450                 455                 460                 


Leu Gly Thr Ala Gly Pro Met Lys Asp Ala Phe Asn Lys Phe Asp Gln 
465                 470                 475                 480 


Pro His Phe Gln Gln His Met Thr Ile Ile Phe Gly Asn Lys Glu Leu 
                485                 490                 495     


Gln Ala Glu Gly Asn Pro Thr Arg Ser Ser Val Phe Thr Ala Asn Gly 
            500                 505                 510         


Asp Lys Asp His Gln Ala Glu Leu Leu Trp Gly Phe Leu Cys Val Val 
        515                 520                 525             


Arg Ser Val Arg Asn Arg Thr Asn His Tyr Asn Val Arg Arg Ala Leu 
    530                 535                 540                 


Leu Arg Leu Leu Asp Glu Gly Ile Val Ser Pro Met Pro Ser Asp Pro 
545                 550                 555                 560 


Lys Lys Glu Arg Val Glu Asn Arg Asn Leu Cys Thr Val Ser Pro Thr 
                565                 570                 575     


Ala Leu Glu Ala Phe Arg Arg Leu Leu Asn Phe Asp Leu Ala Ile Gln 
            580                 585                 590         


Lys Glu Ala Val Arg Thr Ala Leu Glu Gln Ala Lys Ala Ser Glu Phe 
        595                 600                 605             


Val Glu Glu Gly Lys Leu Arg Gly Leu Val Ser Glu Leu Ala Gly Thr 
    610                 615                 620                 


Glu Asp Met Pro Ala Leu His Ile Pro Arg Phe Ser Ala Val Met Asp 
625                 630                 635                 640 


Lys Val Arg Arg Leu Ala Asp Asn Arg Asp Val Gly Leu Asp Pro Ile 
                645                 650                 655     


Leu Ser Thr Leu Gln Arg Ser Leu Pro Pro Thr Asp Lys Gln Ala Glu 
            660                 665                 670         


Ser Asp Ala Ala Arg Cys Arg Tyr Arg Leu Leu Leu Glu Leu Tyr Lys 
        675                 680                 685             


Ser Gly Phe Arg Ser Trp Phe Ser Gly Ile Gln Ser Asn Glu Glu Asn 
    690                 695                 700                 


Asn Arg Glu Ile Cys His Trp Ala Val Lys Gln Val Gly Arg Ala Lys 
705                 710                 715                 720 


Asp Ala Arg Lys Ser Glu Tyr Asp Lys Lys Thr Lys Arg His Tyr Arg 
                725                 730                 735     


Ser Pro Asn Ser Leu Ile Asp Asp Leu Gly Leu Asp Lys Phe Asp Asp 
            740                 745                 750         


Leu Thr Asp Leu Leu Glu Ala Leu Ala Ser Gln Ser Thr Arg Glu His 
        755                 760                 765             


Asp Gln Asn Leu Lys Tyr Val Pro Asp Ala Arg Val Gln Ser Gln Met 
    770                 775                 780                 


Ser Asn Arg Ile Glu Glu Phe Arg Gln Glu Leu Phe Ala His Ile Phe 
785                 790                 795                 800 


Thr Lys Tyr Leu Asp Thr His Asp Phe Gly Trp Ile Gly Ala Ile Glu 
                805                 810                 815     


Val Arg Arg Glu Ala Cys Asp Leu Ala Asp Val Val Ser Ala Phe Glu 
            820                 825                 830         


Val Arg Asp Gln Lys Phe Asp Ala Asp Trp His Ser Gln Phe Tyr Ala 
        835                 840                 845             


Trp Leu Tyr Met Val Pro Pro Ile Glu Ala Ser Arg Leu Arg His Gln 
    850                 855                 860                 


Met Arg Lys Ser Ala Val Met Asp Asp Lys Trp Ser Thr Thr Leu Glu 
865                 870                 875                 880 


Leu Thr Ser Gly Asp Arg Lys Thr Arg Asp Asp His Ala Gln Asp Val 
                885                 890                 895     


Leu Ala Asp Met Asp Arg Leu Phe Ser Leu Tyr Thr Lys Val Gln Ala 
            900                 905                 910         


Ala Gly Phe Asn Gly Gln Glu His Glu Ser Ala Leu Gly Ser Lys Ser 
        915                 920                 925             


Leu Phe Tyr Glu Asp Gly Asn Gln Phe Asp Glu Val Tyr Ser Pro Asp 
    930                 935                 940                 


Thr Glu Thr His Asn Lys Thr Phe Pro Gly Thr Arg Arg Gly Leu Arg 
945                 950                 955                 960 


Gln Leu Val Arg Tyr Ala His Leu Pro Ala Leu Glu Gly Val Phe Lys 
                965                 970                 975     


Lys His Arg Ile Thr Lys Ala Glu Val Glu Thr Phe Val Ala Leu Tyr 
            980                 985                 990         


Asp Glu Asn Arg Arg Asp Pro Gly  Ser Val Ala His Met  Leu Arg Arg 
        995                 1000                 1005             


Glu Lys  Leu Arg Thr Glu Ile  Leu Arg Ser Ile His  Asp Gly Pro 
    1010                 1015                 1020             


Lys Pro  Lys Asp Lys Asp Phe  Trp Pro Lys Leu Glu  Ala Lys Cys 
    1025                 1030                 1035             


Leu Glu  Tyr Arg Thr Val Ala  Thr Glu Thr Ala Ile  Tyr Asn Phe 
    1040                 1045                 1050             


Gln Ala  Asn Ala Ala Arg Leu  Asn Asp His Ala Arg  Leu His Gln 
    1055                 1060                 1065             


Ile Val  Met Arg Val Val Ala  Arg Leu Thr Asp Tyr  Ala Leu Ile 
    1070                 1075                 1080             


Trp Glu  Arg Asp Arg Leu Phe  Ala Phe Val Gly Met  Leu Tyr Arg 
    1085                 1090                 1095             


Gln Thr  Gly Gly Thr Gly Ile  Asn Pro Ala Met Arg  His Ala Glu 
    1100                 1105                 1110             


Lys Thr  Asn Ala Pro Pro Arg  Ile Gly Ile Leu Val  Ser Asp Ser 
    1115                 1120                 1125             


Ala Leu  Ala Lys Lys Leu Asn  Ser Asn Ser Ala Glu  Val Phe Ile 
    1130                 1135                 1140             


Pro Tyr  Leu Asp Thr Glu Thr  Gly Phe Asp Ala Pro  Arg Phe Asp 
    1145                 1150                 1155             


Asp Leu  Cys Thr Leu Leu Ser  His Glu His Ala Lys  Glu Phe Arg 
    1160                 1165                 1170             


Phe His  Phe Leu Glu Val Gly  Glu Glu Asn Ser Lys  Asp Glu Ala 
    1175                 1180                 1185             


Arg Arg  Leu Asn Glu Glu Thr  Met Gly His Arg Lys  Arg Pro Ala 
    1190                 1195                 1200             


Phe Lys  Arg Gly Thr Arg Arg  Gln Gly Ile Arg Asn  Asp Leu Ala 
    1205                 1210                 1215             


His His  Asn Val Leu Asp Leu  Ala Gly Gly Ala Gly  Pro Asn Leu 
    1220                 1225                 1230             


Thr Tyr  Val Val Asn Ala Val  Arg Ser Leu Leu Ser  Tyr Asp Arg 
    1235                 1240                 1245             


Lys Leu  Lys Asn Ala Val Pro  Lys Ser Ile Lys Arg  Ile Leu Gly 
    1250                 1255                 1260             


Glu Glu  Gly Leu Ile Ile Glu  Trp Gln Met Asn Tyr  Asp Arg Leu 
    1265                 1270                 1275             


Lys Lys  Pro Thr Val Tyr Pro  Asn Val Glu Thr His  Leu Thr Met 
    1280                 1285                 1290             


Val Pro  Pro Arg His Met Thr  Ala Pro Val Ser Phe  Thr Leu Pro 
    1295                 1300                 1305             


Arg Ala  Ser Val Arg Leu Ala  Ser Met Val Lys Ala  Val Phe Asp 
    1310                 1315                 1320             


Phe Gly  Ser Ser Gly Tyr Gly  Glu Glu Arg Met Ile  Gly Gly Arg 
    1325                 1330                 1335             


Thr Ala  Lys Gln Ala Val Tyr  Pro Asp Asp Phe Thr  Arg Arg Phe 
    1340                 1345                 1350             


Pro Gln  Thr Pro Met Gly Leu  Lys Gln Ala Thr Arg  Leu Val Phe 
    1355                 1360                 1365             


Ala Ser  Glu Asn Ser 
    1370             


<210>  882
<211>  1287
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  882

Met Arg Ile Gly Lys Val Gln Gly Arg Thr Phe Thr Gly Phe Asp Asn 
1               5                   10                  15      


Ala Arg Gly Lys Thr Leu Arg Arg Arg Leu Leu Thr Arg Pro Asp Asn 
            20                  25                  30          


Glu Ala Arg Ser Leu Ser Glu His Leu Ala His Asp Pro Lys Ala Leu 
        35                  40                  45              


Ile Gly Gln Ala Ile Ser Arg Ile Asp Thr Ile Tyr Gln Lys Pro Lys 
    50                  55                  60                  


Thr Gly Lys Pro Thr Pro Glu Gln Phe Gly His Arg Asp Thr Leu Gly 
65                  70                  75                  80  


Trp Ala Tyr Trp Lys Leu Leu Val Ala Ser Tyr Pro Glu Val Glu Gly 
                85                  90                  95      


His Arg Asp Leu Phe Val Arg Arg Leu His Pro Tyr Gly Asp Thr Pro 
            100                 105                 110         


Pro Lys Ser His Gly Gln Lys Glu Gly Glu His Gln Lys Gly Gly Lys 
        115                 120                 125             


Pro Gln Leu Glu Gly Arg Trp His Gly Val Met Ala Gln His Gly Lys 
    130                 135                 140                 


Asn Pro Asp Gln Ile Ala Ala Arg Leu Phe Asp His Leu His Asn Ser 
145                 150                 155                 160 


Glu Leu Arg Phe Gly Gly Thr Ala Ser Gly Glu Pro Arg Thr Arg Pro 
                165                 170                 175     


Gly Lys Glu Ala Thr Pro Thr Gly Leu Ile Gly Ala Arg Ala Lys Thr 
            180                 185                 190         


Ile Glu His Ser Val Leu Pro Arg Asp Ala Lys Arg Phe Val Ala Glu 
        195                 200                 205             


Trp Arg Gly Glu Asp Gln Glu Arg Tyr Ala Gly Ala Arg Asp Ile Ala 
    210                 215                 220                 


Ala Ala Ile Ser Ala Gly Leu Asn Asp Lys Asp Gln Lys Ser Gly Ser 
225                 230                 235                 240 


Gly Arg Lys Ser Ala Val Ile Gly Lys Leu Leu Ser Asp His Leu Glu 
                245                 250                 255     


Thr Leu Thr Gly Asn Arg Lys Cys Arg Phe Asp Pro Lys Ser Thr Ala 
            260                 265                 270         


Glu Thr Leu Glu Leu Arg Asp Gly Glu Ser Val Asp Asp Arg Arg Arg 
        275                 280                 285             


Ile Leu Glu Leu His Ala Glu Val Lys Ala Thr Tyr Lys Arg Met Ala 
    290                 295                 300                 


Ala Trp Lys Pro Ala Lys Leu Pro Arg Asn Ser Asp Glu Leu Phe Arg 
305                 310                 315                 320 


Leu Val Arg Gln Gln Ala Asp Asn Arg Ile Leu Asn His Leu Val Arg 
                325                 330                 335     


Val Gly Arg Ile Ser Val Tyr Ser Glu Gln Ser Asp Ala Leu Ser Glu 
            340                 345                 350         


Ser Gln Phe Trp Thr Ser Gly Gly Gln Thr Gln Ile Lys Glu Ser Glu 
        355                 360                 365             


Val Phe Ala Arg Leu Trp Ile Gly Ala Ile Ser Arg Ala Ser Tyr Ser 
    370                 375                 380                 


Met Lys Ala Trp Leu Glu Pro Glu Gly Thr Val Phe Asn Pro Ser Ile 
385                 390                 395                 400 


Asn Asp Phe Asp Val Thr Ser Ser His Asn Thr Asn Arg Ile Leu Glu 
                405                 410                 415     


Asp Ser Gly Arg Leu Ser Asn Ala Met Ala Arg Arg Ala Ile Tyr Phe 
            420                 425                 430         


Gly Glu Thr Pro Glu Phe Asp Ala Leu Gly Glu Glu Asp Gln Arg Val 
        435                 440                 445             


Leu Val Lys Lys Cys Leu Asp Ala Leu Ser Ala Cys Arg Asn Arg Thr 
    450                 455                 460                 


Phe His His Gly Gln Arg Ala Lys Phe Leu Lys Glu Val Arg Lys Gly 
465                 470                 475                 480 


Leu Lys Glu Lys Glu Ala Asp Ser Ala Gly Pro Ala Ala Trp Glu Gly 
                485                 490                 495     


Ile Arg Glu Val Ile Gln Ala Asp Ala Arg Asn Leu Gly Ala Arg Leu 
            500                 505                 510         


Leu Gln Asp Leu Thr Gly Ala Lys Val His Ser Phe Ala Thr Asp Pro 
        515                 520                 525             


Glu Phe Arg His Leu Tyr Glu Ser Val Ala Ala Thr Leu Thr Ala Gly 
    530                 535                 540                 


Gly Glu Leu Glu Ala Ala Leu Pro Arg Leu Lys Asn Val Leu Lys Arg 
545                 550                 555                 560 


Ala Glu Gly Val Arg Cys Tyr Leu Asp Thr Pro Ser Gln Arg Arg Glu 
                565                 570                 575     


Gly Asp Glu Ser Leu Ile Ala Arg Leu Pro Val Ala Pro Val Pro Arg 
            580                 585                 590         


Glu Leu Asp Asp Ala Ala Thr Lys Ala Arg His Ser Ala Leu Leu Arg 
        595                 600                 605             


Leu Tyr Asp Gly Pro Phe Arg Pro Trp Ala Thr Glu Leu Arg Gly Glu 
    610                 615                 620                 


Arg Leu Ser Asp Tyr Ala Ala Arg Ala Lys Arg Leu Ala Thr Arg Leu 
625                 630                 635                 640 


Ala Lys Ser Thr Asn Thr Ala Ser Pro Tyr Pro Asp Ser Val Glu Gly 
                645                 650                 655     


Arg Ser Val Arg Leu Arg Asp Pro Ile Thr Ala Asp Thr Ala Pro Glu 
            660                 665                 670         


Thr Leu Lys Thr Tyr Leu Ser Ala Leu Thr Ala Glu Thr Ala Thr Glu 
        675                 680                 685             


Phe Arg Val Gln Lys Gly Tyr Glu Ser Asp Gly Glu Lys Ala Lys Glu 
    690                 695                 700                 


Gln Ala Glu Phe Ile Glu Asp Phe Arg Arg Asp Met Ile Ala Leu Ala 
705                 710                 715                 720 


Phe Gln Asp Phe Ile Arg Asp His Gly Phe Ala Trp Leu Leu Asp Ile 
                725                 730                 735     


Ala Ser Lys Ala Glu Pro Ser Asn Asp Ala Pro Asn Leu Pro Asp Pro 
            740                 745                 750         


Val Asp Thr Gly Lys Asp Thr Val Phe Glu Asp Trp Gln Ala Leu Leu 
        755                 760                 765             


Tyr Leu Phe Leu His Phe Val Pro Ala Asp Asp Val Ser Gln Leu Leu 
    770                 775                 780                 


His Gln Leu Arg Lys Trp Asp Ala Leu Gln Asp Lys Tyr Glu Leu Ala 
785                 790                 795                 800 


Glu Pro Gly Glu Thr Leu Gly Gln Thr Lys Ala Asp Thr Arg Lys Ile 
                805                 810                 815     


Val Gly Gln Phe Arg Asp Cys Leu Thr Leu Phe Leu Lys Thr Gly Asp 
            820                 825                 830         


Ala Arg Phe Asp Gly Glu Gly Val Glu Leu Pro Leu Ser Asp Phe Gln 
        835                 840                 845             


Glu Leu Phe Glu Ser Pro Ala Thr Phe Lys Glu Leu Phe Leu Ala Glu 
    850                 855                 860                 


Pro Ala Glu Asn Asp Ala Ser Glu Thr Asp Asp Gln Asp Ala Pro Gly 
865                 870                 875                 880 


Glu Lys His Arg Val Thr Arg Thr Arg Arg Gly Leu Arg Gln Ile Leu 
                885                 890                 895     


Arg Tyr Asn His Met Pro Val Leu Arg Asp Leu Phe Leu Ala His Lys 
            900                 905                 910         


Val Thr Asp Ala Glu Val Asp Gly Leu Gln Ala Leu Glu Val Asp Asp 
        915                 920                 925             


Pro Gln Thr Gly Glu Ser Gln Ile Gly Ala Ala Gln Arg Ile Arg Thr 
    930                 935                 940                 


Glu Ile His His His Thr Ser Asn Asp Lys Gln Ile Ser Glu Ala Lys 
945                 950                 955                 960 


Val Glu Glu Tyr Arg Arg Ala Leu Ser Thr Ile Glu Arg His Arg Phe 
                965                 970                 975     


Leu Val Gly Arg Val Tyr Leu Gly Asp His Ile Arg Val His Lys Leu 
            980                 985                 990         


Met Met Asp Val Met Gly Arg Leu  Val Asp Phe Ala Gly  Ala Trp Glu 
        995                 1000                 1005             


Arg Glu  Ala Ala Asp Gly Asp  Arg Lys Gly Phe Ile  Ser Arg Ala 
    1010                 1015                 1020             


Ile Ala  Leu Pro Glu Val Ala  Glu Gly Tyr Ala Ala  Asp Arg Leu 
    1025                 1030                 1035             


Lys Thr  Val Ala Arg Arg Val  Leu Asp Asp Gly Glu  Ala Arg Arg 
    1040                 1045                 1050             


Ile Arg  Asn Asp Leu Gly His  Phe Asn Asp Leu Ala  Pro Thr Ser 
    1055                 1060                 1065             


Gly Pro  Ala Asn Leu Thr Phe  Val Val Asn Arg Ala  Arg Arg Met 
    1070                 1075                 1080             


Met Arg  His Asp Arg Lys Arg  Lys Asn Ala Val Thr  Lys Ser Val 
    1085                 1090                 1095             


Ile Glu  Ile Leu Asn Arg Gln  Gly Leu Gly Ile Glu  Trp Thr Met 
    1100                 1105                 1110             


Arg Asn  His Glu Leu Cys Glu  Ala Lys Leu Trp Gln  Asn Pro Val 
    1115                 1120                 1125             


Lys His  Leu Gly Phe Ala Thr  Leu Glu Gly Arg Gly  Lys Lys Trp 
    1130                 1135                 1140             


Arg Arg  Pro Phe Glu Ala Arg  Tyr Gly Asp Ala Tyr  Met Ala Met 
    1145                 1150                 1155             


Val Ala  Gln Leu Phe Asp Gly  Thr Val Thr Ser Pro  Pro Ala Lys 
    1160                 1165                 1170             


Gly Pro  Pro Gln Ser Gly Lys  Ser Gly Gly Lys Pro  Gly Lys Gly 
    1175                 1180                 1185             


Ala Glu  Gly Gly Ala Lys Glu  Lys Ser Arg Ser Pro  Thr Arg Met 
    1190                 1195                 1200             


Glu Glu  Gly Gly Val Tyr Glu  Gly Arg Val Ala Lys  Ala Lys Ser 
    1205                 1210                 1215             


Asp Lys  Gly Phe Gly Phe Leu  Leu Val Glu Gly Ala  Gln Glu Glu 
    1220                 1225                 1230             


Ile Phe  Leu His Ile Tyr Gly  Ile Ser Gly Asn Arg  Pro Ala Arg 
    1235                 1240                 1245             


Ile Glu  Asn Gly Gln Arg Tyr  Arg Phe Thr Leu Gly  Ile Asp Arg 
    1250                 1255                 1260             


Asp Arg  Glu Arg Arg Lys Glu  Arg Ala Trp Val Ala  Arg Glu Ala 
    1265                 1270                 1275             


Val Arg  Ile Asp Glu Asn Arg  Ser Lys 
    1280                 1285         


<210>  883
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  883

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Lys Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn Gln Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Ile Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Asn Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Val Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Phe Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Gln Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Lys Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Met Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Lys Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Cys Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Lys Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ala Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asp Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Met Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Ile Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Cys Ile  Ser Ser Ile Lys Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Thr Leu Ile Thr Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Ser Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Gly Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asp Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  884
<211>  1104
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  884

Met Arg Ile Val Lys Pro His Gly Thr Ser Glu Thr His Phe Asp Lys 
1               5                   10                  15      


Glu Gly Arg Ile Arg Arg Tyr Val His Ser Asp Ser Phe Pro Cys Glu 
            20                  25                  30          


Pro Leu Glu Pro Lys Glu Phe Ala Thr Arg His Pro Lys Leu Val Ile 
        35                  40                  45              


Ala Gln Trp Val Ser Cys Ile Asp Lys Val Ile Thr Arg Pro His Gly 
    50                  55                  60                  


Asp Gly Leu Pro Ser Glu Thr Gln Trp Ser Leu Arg Asn Gly Leu Gly 
65                  70                  75                  80  


Lys Ala Ala Trp Asp Leu Ile Val Glu Arg Gly Leu Leu Asp Ala Pro 
                85                  90                  95      


Glu Lys Arg Leu Lys Arg Phe Glu Arg Gln Trp Trp Ala Arg Ile His 
            100                 105                 110         


Pro Tyr Gly Asn Glu Thr Asp Ala Asn Thr Pro Arg Asn Pro Tyr Gly 
        115                 120                 125             


His Trp Tyr Arg Ser Leu Ala Gly Gly Val Asp Ile Ala Glu Phe Asp 
    130                 135                 140                 


Pro Ala Thr Val Ala Asn Met Ile Tyr Ala His Leu Tyr Glu Asn Ala 
145                 150                 155                 160 


Ser Arg Thr His Pro Glu His Gly Pro Arg Arg Ser Gly Leu Ile Pro 
                165                 170                 175     


Glu Arg Ser Glu Ser Ile Ala Lys Ser Val Pro Ala Arg Thr Ala Pro 
            180                 185                 190         


Gly Gly Gly Arg Leu Ser Pro Pro Trp Asp Ala Ser Asp Gly Ala Ile 
        195                 200                 205             


Tyr Leu Glu Ala Gly Asp Val Ala Ala Thr Met Leu Glu Arg Leu Glu 
    210                 215                 220                 


Lys His Phe Gly Glu Arg His Ala Lys Leu Arg Arg Ile Cys Ala Ala 
225                 230                 235                 240 


Thr Leu Ala Glu His Leu Thr Arg Leu Arg Arg Glu Val Leu His Ile 
                245                 250                 255     


Ser Asp Gly Asp Arg Leu Pro Glu Ser Leu Tyr Gln Leu His Glu Gln 
            260                 265                 270         


Val Arg Arg Ser Tyr Ser Asp Ile Leu Lys Gly Asp Gln Arg Tyr Leu 
        275                 280                 285             


Ser Lys Lys Leu Pro Ser Ser Gly Asp Gln Leu Val Ser Leu Val Glu 
    290                 295                 300                 


Ser Lys Arg Leu Asn Arg Glu Val Ala Ala Leu Ile Arg Leu Gly Arg 
305                 310                 315                 320 


Val Ile His Tyr Glu Ser Thr Ala Glu Asn Gly Pro Ser His Thr Ser 
                325                 330                 335     


Asn Val Leu Asp His Trp Pro Ser Gln Thr Asp Ser Ser Arg Phe Trp 
            340                 345                 350         


Leu Ser Ala Gly Gln Thr Glu Ile Lys Arg Asn Glu Ala Phe Val Arg 
        355                 360                 365             


Ile Trp Arg Gly Ile Leu Ala Arg Ala Ala Arg Thr Ala Thr Asp Trp 
    370                 375                 380                 


Ala Asp Pro Glu Arg Ala Ile Pro Arg Asp Val Leu Gly Ala Lys Gln 
385                 390                 395                 400 


Leu Ser Glu Ala Val Thr Asn Ile Thr Asp Thr Ala Phe Asp Arg Lys 
                405                 410                 415     


Ala Lys Leu Leu Phe Gly Asn Arg Ser Asp Leu Leu Thr Ser Leu Pro 
            420                 425                 430         


Leu Glu Arg Lys Arg Gln Val Leu Asp Leu Ala Leu Arg Gly Leu Gly 
        435                 440                 445             


Gln Leu Arg Asn Asn Ala Phe His Phe Val Gly Leu Glu Ala Phe Leu 
    450                 455                 460                 


Ala Ser Leu Arg Gly Leu Asp Gly Ile Ala Asp Ala Asp Thr Arg Thr 
465                 470                 475                 480 


Val Leu Asp His Ile Trp Arg Asp Asp Thr Lys Asp Arg Asn Thr Arg 
                485                 490                 495     


Leu Val Gln Thr Ile Arg Ala Ser Asn Ala Pro Ala Tyr Phe Ser Arg 
            500                 505                 510         


Gln Glu Met Glu Gly Phe Val Ser Ser Ile Ala Arg Thr Pro Ala Val 
        515                 520                 525             


Phe Leu Glu Leu Pro Ala Phe Gly Arg Ile Leu Arg Arg Ala Ser Val 
    530                 535                 540                 


Ala Trp Thr Ile Asp Arg Tyr Arg Leu Thr Leu Pro Ala Pro Lys Ala 
545                 550                 555                 560 


Val Gly Glu Pro Val Ala Ala Glu Cys Gln Arg Val Cys Leu Gly Leu 
                565                 570                 575     


Ile Tyr Asp Arg Ala Phe Gly Asp Trp Leu Gln Val Leu Glu Thr Glu 
            580                 585                 590         


Arg Leu Arg Asp Cys Val Asp Arg Ala Val Thr Arg Ala Ser Val Glu 
        595                 600                 605             


Ala Arg Arg Val Thr Arg Asp Asp Thr Val Asn Ala Arg Thr Ile Gly 
    610                 615                 620                 


Lys Phe Lys Ile Thr Gln Gly Asp Thr Leu Glu Ser Phe Phe Ser Arg 
625                 630                 635                 640 


Leu Thr Ala Ala Val Thr Arg Glu Leu Arg Gln Thr Asp Ala Arg Lys 
                645                 650                 655     


Gln Thr Lys Arg Ala Ala Ser Lys His Leu Asp Asp Leu Arg Cys Asp 
            660                 665                 670         


Val Val Ala Gln Leu Phe Glu Ile Tyr Leu Lys Glu Ala Asp Leu Gly 
        675                 680                 685             


Trp Leu Leu Ser Gly Phe Gln Thr Arg Lys Pro Thr Gly Ala Ser Lys 
    690                 695                 700                 


Thr Asp Ala Ala Phe Cys Pro Pro Pro Ser Ser Ala Gln Thr Phe Gln 
705                 710                 715                 720 


Ala Trp Glu Pro Ile Leu Tyr Phe Ile Leu His Leu Val Pro Val Asp 
                725                 730                 735     


Thr Thr Thr Arg Leu Ala His Gln Val Gly Arg Phe Arg Asp Gly Gly 
            740                 745                 750         


Gln Ile Asp Thr Gly Leu Ile Glu Gly Leu Gln Arg Thr Leu Asp Leu 
        755                 760                 765             


Tyr Arg Val Met His Asp Ala Lys Phe Ala Gly Ala Ala Ser Gly Leu 
    770                 775                 780                 


Arg Pro Asp Glu Met Arg Ser Ile Leu Leu Lys Thr Gly Leu Tyr Ser 
785                 790                 795                 800 


Gly Ala Thr Glu Gly Thr Glu Leu Ala Phe Glu Thr Arg Gly Leu Arg 
                805                 810                 815     


Glu Phe Phe Arg Phe Gly Asp His His Leu Phe Thr Thr Asp Phe Ala 
            820                 825                 830         


Gln Asn Pro Val Thr Arg Asp Gln Phe His Glu Ile Lys Ser Leu Arg 
        835                 840                 845             


Ala Asp Leu Ala Leu Ala Gln Asp Arg Arg Ser Ala Leu His Ala Glu 
    850                 855                 860                 


Trp Val Ser Asn Gly Lys Ala Leu Ser Gly Ala Lys His Asp Glu Tyr 
865                 870                 875                 880 


Arg Ala Leu Leu Asn Arg Ile Glu Arg Gly Arg His Leu Ser Asp His 
                885                 890                 895     


Ala Glu Leu Arg Asp His Leu Arg Leu His Gly Ile Leu Ile Asp Val 
            900                 905                 910         


Leu Ala Arg Leu Leu Asp Phe Ala Gly Gln Trp Glu Arg Asp Leu Tyr 
        915                 920                 925             


Phe Thr Thr Leu Ala Leu Ile His Leu Ala Gly Thr Thr Pro Gln Asp 
    930                 935                 940                 


Ala Phe Asp Asp Arg Arg Gly Trp His Ala Val Arg Thr Gly Gln Ile 
945                 950                 955                 960 


Leu Ala Ala Leu Arg Ser Thr Arg Asp Thr Pro Glu Met Gln Asp Ile 
                965                 970                 975     


Leu Ala Lys Leu Ala Met Val Phe Asn Ile Asp Met Pro Gly Val Arg 
            980                 985                 990         


Gly Ala Asn Val Arg Thr Arg Asn  Asp Leu Ala His Phe  Asn Cys Leu 
        995                 1000                 1005             


His Thr  Pro Ala Ala Ser Ile  Asp Leu Thr Ala Leu  Ile Asn Arg 
    1010                 1015                 1020             


Thr Arg  Ala Leu Met His Tyr  Asp Arg Lys Gln Glu  Asn Ala Val 
    1025                 1030                 1035             


Ser Lys  Ser Val Ile Glu Leu  Leu Asp Arg His Lys  Leu Val Leu 
    1040                 1045                 1050             


Ser Trp  Thr Phe Ser Gly Gly  Gln Leu Gly Lys Ser  Thr Val Arg 
    1055                 1060                 1065             


Pro Lys  Val Ile Arg His Leu  Glu Gln Pro Glu Val  Lys Glu Cys 
    1070                 1075                 1080             


Leu Val  Ser Thr Ala Phe Ser  Ala Ala Val Gly Arg  Leu Phe Gly 
    1085                 1090                 1095             


Ala Thr  Glu Lys Asp Gly 
    1100                 


<210>  885
<211>  1287
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  885

Met Arg Ile Gly Lys Val Gln Gly Arg Thr Phe Thr Gly Phe Asp Asn 
1               5                   10                  15      


Ala Arg Gly Lys Thr Leu Arg Arg Arg Leu Leu Thr Arg Pro Asp Asn 
            20                  25                  30          


Glu Ala Arg Ser Leu Ser Glu His Leu Ala His Asp Pro Lys Ala Leu 
        35                  40                  45              


Ile Gly Gln Ala Ile Ser Arg Ile Asp Thr Ile Tyr Gln Lys Pro Lys 
    50                  55                  60                  


Thr Gly Lys Pro Thr Pro Glu Gln Phe Gly His Arg Asp Thr Leu Gly 
65                  70                  75                  80  


Trp Ala Tyr Trp Lys Leu Leu Val Ala Ser Tyr Pro Glu Val Glu Gly 
                85                  90                  95      


His Arg Asp Leu Phe Val Arg Arg Leu His Pro Tyr Gly Asp Thr Pro 
            100                 105                 110         


Pro Lys Ser His Gly Gln Lys Glu Gly Glu His Gln Lys Gly Gly Lys 
        115                 120                 125             


Pro Gln Leu Glu Gly Arg Trp His Gly Val Met Ala Gln His Gly Lys 
    130                 135                 140                 


Asn Pro Asp Gln Ile Ala Ala Arg Leu Phe Asp His Leu His Asn Ser 
145                 150                 155                 160 


Glu Leu Arg Phe Gly Gly Thr Ala Ser Gly Glu Pro Arg Thr Arg Pro 
                165                 170                 175     


Gly Lys Glu Ala Thr Pro Thr Gly Leu Ile Gly Ala Arg Ala Lys Thr 
            180                 185                 190         


Ile Glu His Ser Val Leu Pro Arg Asp Ala Lys Arg Phe Val Ala Glu 
        195                 200                 205             


Trp Arg Gly Glu Asp Gln Glu Arg Tyr Ala Gly Ala Arg Asp Ile Ala 
    210                 215                 220                 


Ala Ala Ile Ser Ala Gly Leu Asn Asp Lys Asp Gln Lys Ser Gly Ser 
225                 230                 235                 240 


Gly Arg Lys Ser Ala Val Ile Gly Lys Leu Leu Ser Asp His Leu Glu 
                245                 250                 255     


Thr Leu Thr Gly Asn Arg Lys Cys Arg Phe Asp Pro Lys Ser Thr Ala 
            260                 265                 270         


Glu Thr Leu Glu Leu Arg Asp Gly Glu Ser Val Asp Asp Arg Arg Arg 
        275                 280                 285             


Ile Leu Glu Leu His Ala Glu Val Lys Ala Thr Tyr Lys Arg Met Ala 
    290                 295                 300                 


Ala Trp Lys Pro Ala Lys Leu Pro Arg Asn Ser Asp Glu Leu Phe Arg 
305                 310                 315                 320 


Leu Val Arg Gln Gln Ala Asp Asn Arg Ile Leu Asn His Leu Val Arg 
                325                 330                 335     


Val Gly Arg Ile Ser Val Tyr Ser Glu Gln Ser Asp Ala Leu Ser Glu 
            340                 345                 350         


Ser Gln Phe Trp Thr Ser Gly Gly Gln Thr Gln Ile Lys Glu Ser Glu 
        355                 360                 365             


Val Phe Ala Arg Leu Trp Ile Gly Ala Ile Ser Arg Ala Ser Tyr Ser 
    370                 375                 380                 


Met Lys Ala Trp Leu Glu Pro Glu Gly Thr Val Phe Asn Pro Ser Ile 
385                 390                 395                 400 


Asn Asp Phe Asp Val Thr Ser Ser His Asn Thr Asn Arg Ile Leu Glu 
                405                 410                 415     


Asp Ser Gly Arg Leu Ser Asn Ala Met Ala Arg Arg Ala Ile Tyr Phe 
            420                 425                 430         


Gly Glu Thr Pro Glu Phe Asp Ala Leu Gly Glu Glu Asp Gln Arg Val 
        435                 440                 445             


Leu Val Lys Lys Cys Leu Asp Ala Leu Ser Ala Cys Arg Asn Arg Thr 
    450                 455                 460                 


Phe His His Gly Gln Arg Ala Lys Phe Leu Lys Glu Val Arg Lys Gly 
465                 470                 475                 480 


Leu Lys Glu Lys Glu Ala Asp Ser Ala Gly Pro Ala Ala Trp Glu Gly 
                485                 490                 495     


Ile Arg Glu Val Ile Gln Ala Asp Ala Arg Asn Leu Gly Ala Arg Leu 
            500                 505                 510         


Leu Gln Asp Leu Thr Gly Ala Lys Val His Ser Phe Ala Thr Asp Pro 
        515                 520                 525             


Glu Phe Arg His Leu Tyr Glu Ser Val Ala Ala Thr Leu Thr Ala Gly 
    530                 535                 540                 


Gly Glu Leu Glu Ala Ala Leu Pro Arg Leu Lys Asn Val Leu Lys Arg 
545                 550                 555                 560 


Ala Glu Gly Val Arg Cys Tyr Leu Asp Thr Pro Ser Gln Arg Arg Glu 
                565                 570                 575     


Gly Asp Glu Ser Leu Ile Ala Arg Leu Pro Val Ala Pro Val Pro Arg 
            580                 585                 590         


Glu Leu Asp Asp Ala Ala Thr Lys Ala Arg His Ser Ala Leu Leu Arg 
        595                 600                 605             


Leu Tyr Asp Gly Pro Phe Arg Pro Trp Ala Thr Glu Leu Arg Gly Glu 
    610                 615                 620                 


Arg Leu Ser Asp Tyr Ala Ala Arg Ala Lys Arg Leu Ala Thr Arg Leu 
625                 630                 635                 640 


Ala Lys Ser Thr Asn Thr Ala Ser Pro Tyr Pro Asp Ser Val Glu Gly 
                645                 650                 655     


Arg Ser Val Arg Leu Arg Asp Pro Ile Thr Ala Asp Thr Ala Pro Glu 
            660                 665                 670         


Thr Leu Lys Thr Tyr Leu Ser Ala Leu Thr Ala Glu Thr Ala Thr Glu 
        675                 680                 685             


Phe Arg Val Gln Lys Gly Tyr Glu Ser Asp Gly Glu Lys Ala Lys Glu 
    690                 695                 700                 


Gln Ala Glu Phe Ile Glu Asp Phe Arg Arg Asp Met Ile Ala Leu Ala 
705                 710                 715                 720 


Phe Gln Asp Phe Ile Arg Asp His Gly Phe Ala Trp Leu Leu Asp Ile 
                725                 730                 735     


Ala Ser Lys Ala Glu Pro Ser Asn Asp Ala Pro Asn Leu Pro Asp Pro 
            740                 745                 750         


Val Asp Thr Gly Lys Asp Thr Val Phe Glu Asp Trp Gln Ala Leu Leu 
        755                 760                 765             


Tyr Leu Phe Leu His Phe Val Pro Ala Asp Asp Val Ser Gln Leu Leu 
    770                 775                 780                 


His Gln Leu Arg Lys Trp Asp Ala Leu Gln Asp Lys Tyr Glu Leu Ala 
785                 790                 795                 800 


Glu Pro Gly Glu Thr Leu Gly Gln Thr Lys Ala Asp Thr Arg Lys Ile 
                805                 810                 815     


Val Gly Gln Phe Arg Asp Cys Leu Thr Leu Phe Leu Lys Thr Gly Asp 
            820                 825                 830         


Ala Arg Phe Asp Gly Glu Gly Val Glu Leu Pro Leu Ser Asp Phe Gln 
        835                 840                 845             


Glu Leu Phe Glu Ser Pro Ala Thr Phe Lys Glu Leu Phe Leu Ala Glu 
    850                 855                 860                 


Pro Ala Glu Asn Asp Ala Ser Glu Thr Asp Asp Gln Asp Ala Pro Gly 
865                 870                 875                 880 


Glu Lys His Arg Val Thr Arg Thr Arg Arg Gly Leu Arg Gln Ile Leu 
                885                 890                 895     


Arg Tyr Asn His Met Pro Val Leu Arg Asp Leu Phe Leu Ala His Lys 
            900                 905                 910         


Val Thr Asp Ala Glu Val Asp Gly Leu Gln Ala Leu Glu Val Asp Asp 
        915                 920                 925             


Pro Gln Thr Gly Glu Ser Gln Ile Gly Ala Ala Gln Arg Ile Arg Thr 
    930                 935                 940                 


Glu Ile His His His Thr Ser Asn Asp Lys Gln Ile Ser Glu Ala Lys 
945                 950                 955                 960 


Val Glu Glu Tyr Arg Arg Ala Leu Ser Thr Ile Glu Arg His Arg Phe 
                965                 970                 975     


Leu Val Gly Arg Val Tyr Leu Gly Asp His Ile Arg Val His Lys Leu 
            980                 985                 990         


Met Met Asp Val Met Gly Arg Leu  Val Asp Phe Ala Gly  Ala Trp Glu 
        995                 1000                 1005             


Arg Glu  Ala Ala Asp Gly Asp  Arg Lys Gly Phe Ile  Ser Arg Ala 
    1010                 1015                 1020             


Ile Ala  Leu Pro Glu Val Ala  Glu Gly Tyr Ala Ala  Asp Arg Leu 
    1025                 1030                 1035             


Lys Thr  Val Ala Arg Arg Val  Leu Asp Asp Gly Glu  Ala Arg Arg 
    1040                 1045                 1050             


Ile Arg  Asn Asp Leu Gly His  Phe Asn Asp Leu Ala  Pro Thr Ser 
    1055                 1060                 1065             


Gly Pro  Ala Asn Leu Thr Phe  Val Val Asn Arg Ala  Arg Arg Met 
    1070                 1075                 1080             


Met Arg  His Asp Arg Lys Arg  Lys Asn Ala Val Thr  Lys Ser Val 
    1085                 1090                 1095             


Ile Glu  Ile Leu Asn Arg Gln  Gly Leu Gly Ile Glu  Trp Thr Met 
    1100                 1105                 1110             


Arg Asn  His Glu Leu Cys Glu  Ala Lys Leu Trp Gln  Asn Pro Val 
    1115                 1120                 1125             


Lys His  Leu Gly Phe Ala Thr  Leu Glu Gly Arg Gly  Lys Lys Trp 
    1130                 1135                 1140             


Arg Arg  Pro Phe Glu Ala Arg  Tyr Gly Asp Ala Tyr  Met Ala Met 
    1145                 1150                 1155             


Val Ala  Gln Leu Phe Asp Gly  Thr Val Thr Ser Pro  Pro Ala Lys 
    1160                 1165                 1170             


Gly Pro  Pro Gln Ser Gly Lys  Ser Gly Gly Lys Pro  Gly Lys Gly 
    1175                 1180                 1185             


Ala Glu  Gly Gly Ala Lys Glu  Lys Ser Arg Ser Pro  Thr Arg Met 
    1190                 1195                 1200             


Glu Glu  Gly Gly Val Tyr Glu  Gly Arg Val Ala Lys  Ala Lys Ser 
    1205                 1210                 1215             


Asp Lys  Gly Phe Gly Phe Leu  Leu Val Glu Gly Ala  Gln Glu Glu 
    1220                 1225                 1230             


Ile Phe  Leu His Ile Tyr Gly  Ile Ser Gly Asn Arg  Pro Ala Arg 
    1235                 1240                 1245             


Ile Glu  Asn Gly Gln Arg Tyr  Arg Phe Thr Leu Gly  Ile Asp Arg 
    1250                 1255                 1260             


Asp Arg  Glu Arg Arg Lys Glu  Arg Ala Trp Val Ala  Arg Glu Ala 
    1265                 1270                 1275             


Val Arg  Ile Asp Glu Asn Arg  Ser Lys 
    1280                 1285         


<210>  886
<211>  1373
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  886

Met Ala Lys His Leu Arg Pro Ile Gly Glu Ser Tyr Thr Asp Phe Leu 
1               5                   10                  15      


Asp Glu Thr Glu Phe Val Arg Leu Gly Arg Gly Leu His Arg Gly His 
            20                  25                  30          


His Gly Val Gln Ile Pro Pro Thr Glu Leu Pro Ser Tyr Leu Ala Glu 
        35                  40                  45              


Tyr Arg Lys Ala Leu Met Arg Gln Val Val Ala Val Leu Asp Lys Val 
    50                  55                  60                  


Val Gly Lys Arg Arg Arg Leu Ser Gly Met His Pro Glu Ala Tyr Arg 
65                  70                  75                  80  


Asp Arg Val His Leu Ala Glu Ala Leu Trp Val Arg Leu Val Ala Arg 
                85                  90                  95      


Val Lys Glu Ile Gly Thr Pro Pro Asp Pro Ser Glu Leu Leu Asp Leu 
            100                 105                 110         


Arg Arg Met Trp Asn Ala Lys Ala His Pro Tyr Ala Glu Tyr Asp Val 
        115                 120                 125             


Val Pro Arg Ala Pro Leu Asn Asp Gly Asn Gly Gln Lys Ile Leu Glu 
    130                 135                 140                 


Cys Arg Glu Val Asp Asp Pro Lys Ile Glu Arg Ser Asp Phe Glu Gly 
145                 150                 155                 160 


Arg Trp His Gly Arg Phe Trp Gln Ser Glu Pro Gly Pro Val Asp Tyr 
                165                 170                 175     


Asn Ala Ile Ala Asp Arg Ile Phe Ala His Leu Phe Asp Gln Glu Ala 
            180                 185                 190         


Val Ile Gly Gly Gly Pro Arg Arg Glu Gly Asn Val Thr Val Pro Asp 
        195                 200                 205             


Glu Asp Ile Asn Gly Gln Pro Gly Pro Ala Thr Gly Lys Gly Leu Ile 
    210                 215                 220                 


Ile Ala Arg Gly Gln Ser Ile Val Lys Ser Ala Ser Asp Pro Arg Arg 
225                 230                 235                 240 


Ser Ser Lys Lys Val Gln Arg Thr Trp Asp Lys Ala Val Glu Arg Arg 
                245                 250                 255     


Tyr Phe Gly Asp Asp Gly Lys Gly Gly Ser Asp Ile Ala Lys Ala Ile 
            260                 265                 270         


Tyr Glu Glu Leu Gly Asp Pro Ala Thr Leu Ala Asp Pro Ile Tyr Ala 
        275                 280                 285             


Ser Trp Phe Gly Ser Arg Leu Tyr Asp His Phe Gly Ser Phe Lys Asn 
    290                 295                 300                 


Ser Leu Pro Leu Glu Leu Lys Asp Pro Phe Lys Glu Gln Ile Trp Ala 
305                 310                 315                 320 


Leu His Asn Ser Val Arg Gln Phe Tyr Gln Arg Met Ala Lys Ser Asp 
                325                 330                 335     


Arg Phe Arg Leu Ala Leu Gln Asn Ala Arg Ser Glu Val Pro Asp Arg 
            340                 345                 350         


Ser Glu Leu Leu Ala Leu Leu Pro Lys Asp His Asp His Leu Leu Leu 
        355                 360                 365             


Val Leu Gly Gly Lys Lys Lys Asn Ala Glu Met Ser Glu Leu Ile Arg 
    370                 375                 380                 


Leu Gly Lys Leu Phe Val His Ala Ser Asp Val Leu His Asp Phe Asp 
385                 390                 395                 400 


Ala Asn Asp Ala Ala Ala Leu Asp Ala Phe Lys Arg Arg Met Ser Phe 
                405                 410                 415     


Leu Ala Thr Ser Ile Gly Gln Ser Glu Ile Lys Gln Thr Glu Thr Phe 
            420                 425                 430         


Ala Arg Thr Trp Arg Gly Ala Val Gly Leu Thr Leu Arg Thr Val Lys 
        435                 440                 445             


Gly Leu Ala Asp Pro Arg Gly Ile Ile Gly Thr Pro Asp Asn Arg Asp 
    450                 455                 460                 


Leu Gly Thr Ala Gly Pro Met Lys Asp Ala Phe Asn Lys Phe Asp Gln 
465                 470                 475                 480 


Pro His Phe Gln Gln His Met Thr Ile Ile Phe Gly Asn Lys Glu Leu 
                485                 490                 495     


Gln Ala Glu Gly Asn Pro Thr Arg Ser Ser Val Phe Thr Ala Asn Gly 
            500                 505                 510         


Asp Lys Asp His Gln Ala Glu Leu Leu Trp Gly Phe Leu Cys Val Val 
        515                 520                 525             


Arg Ser Val Arg Asn Arg Thr Asn His Tyr Asn Val Arg Arg Ala Leu 
    530                 535                 540                 


Leu Arg Leu Leu Asp Glu Gly Ile Val Ser Pro Met Pro Ser Asp Pro 
545                 550                 555                 560 


Lys Lys Glu Arg Val Glu Asn Arg Asn Leu Cys Thr Val Ser Pro Thr 
                565                 570                 575     


Ala Leu Glu Ala Phe Arg Arg Leu Leu Asn Phe Asp Leu Ala Ile Gln 
            580                 585                 590         


Lys Glu Ala Val Arg Thr Ala Leu Glu Gln Ala Lys Ala Ser Glu Phe 
        595                 600                 605             


Val Glu Glu Gly Lys Leu Arg Gly Leu Val Ser Glu Leu Ala Gly Thr 
    610                 615                 620                 


Glu Asp Met Pro Ala Leu His Ile Pro Arg Phe Ser Ala Val Met Asp 
625                 630                 635                 640 


Lys Val Arg Arg Leu Ala Asp Asn Arg Asp Val Gly Leu Asp Pro Ile 
                645                 650                 655     


Leu Ser Thr Leu Gln Arg Ser Leu Pro Pro Thr Asp Lys Gln Ala Glu 
            660                 665                 670         


Ser Asp Ala Ala Arg Cys Arg Tyr Arg Leu Leu Leu Glu Leu Tyr Lys 
        675                 680                 685             


Ser Gly Phe Arg Ser Trp Phe Ser Gly Ile Gln Ser Asn Glu Glu Asn 
    690                 695                 700                 


Asn Arg Glu Ile Cys His Trp Ala Val Lys Gln Val Gly Arg Ala Lys 
705                 710                 715                 720 


Asp Ala Arg Lys Ser Glu Tyr Asp Lys Lys Thr Lys Arg His Tyr Arg 
                725                 730                 735     


Ser Pro Asn Ser Leu Ile Asp Asp Leu Gly Leu Asp Lys Phe Asp Asp 
            740                 745                 750         


Leu Thr Asp Leu Leu Glu Ala Leu Ala Ser Gln Ser Thr Arg Glu His 
        755                 760                 765             


Asp Gln Asn Leu Lys Tyr Val Pro Asp Ala Arg Val Gln Ser Gln Met 
    770                 775                 780                 


Ser Asn Arg Ile Glu Glu Phe Arg Gln Glu Leu Phe Ala His Ile Phe 
785                 790                 795                 800 


Thr Lys Tyr Leu Asp Thr His Asp Phe Gly Trp Ile Gly Ala Ile Glu 
                805                 810                 815     


Val Arg Arg Glu Ala Cys Asp Leu Ala Asp Val Val Ser Ala Phe Glu 
            820                 825                 830         


Val Arg Asp Gln Lys Phe Asp Ala Asp Trp His Ser Gln Phe Tyr Ala 
        835                 840                 845             


Trp Leu Tyr Met Val Pro Pro Ile Glu Ala Ser Arg Leu Arg His Gln 
    850                 855                 860                 


Met Arg Lys Ser Ala Val Met Asp Asp Lys Trp Ser Thr Thr Leu Glu 
865                 870                 875                 880 


Leu Thr Ser Gly Asp Arg Lys Thr Arg Asp Asp His Ala Gln Asp Val 
                885                 890                 895     


Leu Ala Asp Met Asp Arg Leu Phe Ser Leu Tyr Thr Lys Val Gln Ala 
            900                 905                 910         


Ala Gly Phe Asn Gly Gln Glu His Glu Ser Ala Leu Gly Ser Lys Ser 
        915                 920                 925             


Leu Phe Tyr Glu Asp Gly Asn Gln Phe Asp Glu Val Tyr Ser Pro Asp 
    930                 935                 940                 


Thr Glu Thr His Asn Lys Thr Phe Pro Gly Thr Arg Arg Gly Leu Arg 
945                 950                 955                 960 


Gln Leu Val Arg Tyr Ala His Leu Pro Ala Leu Glu Gly Val Phe Lys 
                965                 970                 975     


Lys His Arg Ile Thr Lys Ala Glu Val Glu Thr Phe Val Ala Leu Tyr 
            980                 985                 990         


Asp Glu Asn Arg Arg Asp Pro Gly  Ser Val Ala His Met  Leu Arg Arg 
        995                 1000                 1005             


Glu Lys  Leu Arg Thr Glu Ile  Leu Arg Ser Ile His  Asp Gly Pro 
    1010                 1015                 1020             


Lys Pro  Lys Asp Lys Asp Phe  Trp Pro Lys Leu Glu  Ala Lys Cys 
    1025                 1030                 1035             


Leu Glu  Tyr Arg Thr Val Ala  Thr Glu Thr Ala Ile  Tyr Asn Phe 
    1040                 1045                 1050             


Gln Ala  Asn Ala Ala Arg Leu  Asn Asp His Ala Arg  Leu His Gln 
    1055                 1060                 1065             


Ile Val  Met Arg Val Val Ala  Arg Leu Thr Asp Tyr  Ala Leu Ile 
    1070                 1075                 1080             


Trp Glu  Arg Asp Arg Leu Phe  Ala Phe Val Gly Met  Leu Tyr Arg 
    1085                 1090                 1095             


Gln Thr  Gly Gly Thr Gly Ile  Asn Pro Ala Met Arg  His Ala Glu 
    1100                 1105                 1110             


Lys Thr  Asn Ala Pro Pro Arg  Ile Gly Ile Leu Val  Ser Asp Ser 
    1115                 1120                 1125             


Ala Leu  Ala Lys Lys Leu Asn  Ser Asn Ser Ala Glu  Val Phe Ile 
    1130                 1135                 1140             


Pro Tyr  Leu Asp Thr Glu Thr  Gly Phe Asp Ala Pro  Arg Phe Asp 
    1145                 1150                 1155             


Asp Leu  Cys Thr Leu Leu Ser  His Glu His Ala Lys  Glu Phe Arg 
    1160                 1165                 1170             


Phe His  Phe Leu Glu Val Gly  Glu Glu Asn Ser Lys  Asp Glu Ala 
    1175                 1180                 1185             


Arg Arg  Leu Asn Glu Glu Thr  Met Gly His Arg Lys  Arg Pro Ala 
    1190                 1195                 1200             


Phe Lys  Arg Gly Thr Arg Arg  Gln Gly Ile Arg Asn  Asp Leu Ala 
    1205                 1210                 1215             


His His  Asn Val Leu Asp Leu  Ala Gly Gly Ala Gly  Pro Asn Leu 
    1220                 1225                 1230             


Thr Tyr  Val Val Asn Ala Val  Arg Ser Leu Leu Ser  Tyr Asp Arg 
    1235                 1240                 1245             


Lys Leu  Lys Asn Ala Val Pro  Lys Ser Ile Lys Arg  Ile Leu Gly 
    1250                 1255                 1260             


Glu Glu  Gly Leu Ile Ile Glu  Trp Gln Met Asn Tyr  Asp Arg Leu 
    1265                 1270                 1275             


Lys Lys  Pro Thr Val Tyr Pro  Asn Val Glu Thr His  Leu Thr Met 
    1280                 1285                 1290             


Val Pro  Pro Arg His Met Thr  Ala Pro Val Ser Phe  Thr Leu Pro 
    1295                 1300                 1305             


Arg Ala  Ser Val Arg Leu Ala  Ser Met Val Lys Ala  Val Phe Asp 
    1310                 1315                 1320             


Phe Gly  Ser Ser Gly Tyr Gly  Glu Glu Arg Met Ile  Gly Gly Arg 
    1325                 1330                 1335             


Thr Ala  Lys Gln Ala Val Tyr  Pro Asp Asp Phe Thr  Arg Arg Phe 
    1340                 1345                 1350             


Pro Gln  Thr Pro Met Gly Leu  Lys Gln Ala Thr Arg  Leu Val Phe 
    1355                 1360                 1365             


Ala Ser  Glu Asn Ser 
    1370             


<210>  887
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  887

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Thr Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  888
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  888

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Pro Gly Thr Asp Thr 
            20                  25                  30          


Ile Gly Leu Lys Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Asp Lys Pro Lys Lys 
    50                  55                  60                  


Trp Lys Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Glu Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Ser Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Met Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Tyr Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ser Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Gln Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Phe 
            660                 665                 670         


Ile Arg Lys Asn Phe Pro Glu Asp Ile Ser Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val Tyr Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Asp Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Asp Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asn  Ser Glu Lys Lys Glu  Ala Tyr Gln Lys Ile  Glu Val Asn 
    1100                 1105                 1110             


Gly Asp  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Val  Tyr Ala Pro Asp Glu  Lys Gly Asp 
    1130                 1135                 1140             


Ile Leu  Lys Glu Gln Cys Thr  Lys Gly Gly Ala Gly  Gly Lys Ile 
    1145                 1150                 1155             


Ser Ala  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Lys Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Lys Gln 
    1250                 1255                 1260             


Thr Thr  Ser Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Ser Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Lys  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Val Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Gly Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Pro Asn 
    1370                 1375                 1380         


<210>  889
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  889

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  890
<211>  1385
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  890

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Lys Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn Gln Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Glu 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Ile Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Asn Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Val Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Phe Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Gln Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Arg Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Val Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asp Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Met Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Ile Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Cys Ile  Ser Ser Ile Lys Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Thr Leu Ile Thr Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Leu Leu Tyr  Tyr Pro Asp 
    1310                 1315                 1320             


Ile Glu  Ser Asn Val Lys Ile  Leu Leu Arg Lys Asp  Asn Phe Asn 
    1325                 1330                 1335             


Gln Asn  Lys Asp Lys Lys Asn  Val Asn Asn Arg Lys  Thr Lys Asn 
    1340                 1345                 1350             


Asn Asn  Lys Asn Gly Asn Arg  Asn Arg Asp Lys Asn  Ser Gly Gly 
    1355                 1360                 1365             


Asp Gly  Leu Thr Tyr Asn Pro  Phe Leu Asn Leu Ile  Phe Asp Leu 
    1370                 1375                 1380             


Pro Glu  
    1385 


<210>  891
<211>  1177
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  891

Met Gly Thr Gly Lys Tyr Arg Ile Thr Lys Ile Gly Arg Asn Trp Lys 
1               5                   10                  15      


Glu Asn Glu Asn Lys Asn Lys Lys Arg Ile Ile Leu Lys Arg Ile Val 
            20                  25                  30          


Ser Asp Gly Glu Val Lys Tyr Val Asn Glu Asn Asp Asn Val Asp Ile 
        35                  40                  45              


Asp Ile Thr Glu Thr Tyr Tyr Gly Ile Leu Ser Asn Asn Lys Ala Lys 
    50                  55                  60                  


Phe Leu Gly Ser Asn Glu Gln Phe Leu Phe Lys Val Asn Lys Met Asp 
65                  70                  75                  80  


Arg Asn Ile Lys Asn Asp Tyr Val Ile Ile Lys Asp Tyr Thr Glu Glu 
                85                  90                  95      


Glu Phe Glu Lys Phe Asp Lys Lys Ile Phe Phe Ser Arg Lys Ile Lys 
            100                 105                 110         


Ile Asn Asn Glu Asp Arg Glu Lys Ile Cys Arg Asn Phe Tyr Glu Asp 
        115                 120                 125             


Glu Arg Glu Ile Met Lys Lys Arg Leu Glu Glu Ala Lys Asn Phe Asn 
    130                 135                 140                 


Asn Ile Ile Phe Asn Ile Cys Asn Lys Ile Phe Lys Leu Glu Tyr Leu 
145                 150                 155                 160 


Asp Tyr Thr Asp Glu Lys Val Tyr Lys Ile Phe Gln Lys Glu Ile Lys 
                165                 170                 175     


Phe Glu Asp Ile Lys Asn Leu Lys Glu Ala Phe Lys Lys Gln Glu Asn 
            180                 185                 190         


Gly Leu Glu Thr Asp Lys Leu Leu Ala Ile Ser Phe Asn Lys Lys Arg 
        195                 200                 205             


Asn Asn Ile Leu Leu Glu Phe Ile Gln Gln Ile Val Arg Gln Lys Phe 
    210                 215                 220                 


Glu Lys Glu Lys Glu Leu Glu Asn Trp Phe Ser His Glu Gly Glu Lys 
225                 230                 235                 240 


Tyr Cys Lys Glu Ile Phe Lys Ile Tyr Ser Asn Met Ser Gln Lys Glu 
                245                 250                 255     


Lys Tyr Ser Lys Leu Leu Gly His Arg Asn Lys Asn Ile Ala Ser Ile 
            260                 265                 270         


Ser Glu Lys Lys Glu Thr Leu Gln Arg Arg Leu Lys Leu Gly Asn Tyr 
        275                 280                 285             


Ser Asp Tyr Asp Leu Arg Lys Tyr Tyr Gln Lys Asp Tyr Lys Glu Glu 
    290                 295                 300                 


Ala Ile Lys Glu Leu Lys Asp Lys Asn Lys Glu Glu Leu Glu Arg Glu 
305                 310                 315                 320 


Ile Glu Glu Leu Ile Lys Lys Asn Tyr Lys Ile Asp Lys Leu Cys Asp 
                325                 330                 335     


Glu Ile Ser Asn Leu Glu Phe Phe Phe Val Glu Ser Lys Lys Glu Asn 
            340                 345                 350         


Lys Asp Lys Met Ser Glu Ile Ile Val Lys Ile Lys Glu His Tyr Lys 
        355                 360                 365             


Lys Asn Val Asn Val Glu Glu Glu Leu Lys Asn Lys Glu Lys Tyr Ile 
    370                 375                 380                 


Leu Ser Leu Ile His Asn Tyr Val Lys Gly Arg Tyr Arg Lys Cys Leu 
385                 390                 395                 400 


Glu Leu Gln Gln Lys Glu Asn Val Asp Phe Glu Asn Leu Gly Lys Arg 
                405                 410                 415     


Ile Lys Glu Ile Phe Asp Ser Asn Glu Val Thr Lys Lys Leu Lys Lys 
            420                 425                 430         


Ser Ile Ile Asn Lys Val Asn Ser Tyr Lys Ile Phe Glu Met Lys Phe 
        435                 440                 445             


Gln Asn Pro Asn Ile Glu Ser Ser Asp Asp Leu Glu Ile Leu Lys Ala 
    450                 455                 460                 


Glu Glu Thr Phe Leu Asn Lys Leu Ser Thr Ala Val Ser Lys Val Gly 
465                 470                 475                 480 


Tyr Thr Leu Asn Ile Leu Leu Gly Val Ser Ser Glu Glu Asp Ile Leu 
                485                 490                 495     


Lys Asn Tyr Asn Met Val Gly Lys Leu Cys Asn Asn Asn Ser Thr Thr 
            500                 505                 510         


Glu Ile Tyr Lys Val Tyr Pro Glu Leu Glu Lys Asn Glu Lys Leu Leu 
        515                 520                 525             


Gln Gly Met Ile His Phe Ile Gln Gly Leu Arg Gln Gln Ser Leu His 
    530                 535                 540                 


Pro Lys Ile Ser Trp Asn Phe Glu Thr Glu Asn Leu Lys Pro Glu Lys 
545                 550                 555                 560 


Leu Glu Arg Leu Lys Glu Lys Lys Asn Ile Lys Ile Arg Asp Cys Val 
                565                 570                 575     


Val His Glu Tyr Asn Leu Asp Lys Lys Glu Lys Asn Glu Val Glu Ile 
            580                 585                 590         


Lys Glu Tyr Phe Glu Lys Ile Glu Lys Lys Leu Pro Asn Tyr Phe Ile 
        595                 600                 605             


Glu Lys Tyr Glu Ser Asn Asn Val Phe Asn Ile Tyr Arg Asp Ser Val 
    610                 615                 620                 


Asp Lys Ile Met Glu Val Val Lys Lys Phe Asn Phe Lys Glu Asp Asn 
625                 630                 635                 640 


Thr Ile Asp Tyr Leu Phe Pro Lys Phe His Lys Ile Tyr Lys Lys Met 
                645                 650                 655     


Cys Lys Leu Glu Asn Ile Thr Cys Lys Ser Glu Asn Thr Asp Asp Arg 
            660                 665                 670         


Gln Asn Gly Ala Arg Lys Tyr Leu Leu Gln Thr Ile Tyr Tyr Tyr Tyr 
        675                 680                 685             


Phe Gln Tyr Glu Ile Glu Asn Asn Arg Asn Asn Ile Phe Lys Tyr Tyr 
    690                 695                 700                 


Arg Asn Lys Ile Lys Thr Glu Lys Asn Ser Tyr Arg Asp Lys Asn Ile 
705                 710                 715                 720 


Glu Ile Leu Tyr Arg Asn Ile Gln Arg Glu Gly Met Leu Asn Asn Arg 
                725                 730                 735     


Leu Leu Gln Met Asn Asn Glu Trp Ile Glu Phe Ile Met Ile Gln Phe 
            740                 745                 750         


Ile Glu Phe Ile Ser Ile Lys Lys Leu Asn Trp Ile Leu Asp Asp Leu 
        755                 760                 765             


Ser Glu Tyr Arg Lys Lys Glu Lys Leu Asp Glu Asn Asp Lys Asn Arg 
    770                 775                 780                 


Leu Leu Lys Ile Leu Lys Gln Lys Met Asn Lys Asn Ile Thr Tyr Ser 
785                 790                 795                 800 


Asn Asp Ser Tyr Val Phe Ile Ser Leu Ala Gln Phe Leu Asp Leu Lys 
                805                 810                 815     


Glu Ile Ser Asn Leu Ile His Asp Ile Lys Lys Phe Val Gln Phe Arg 
            820                 825                 830         


Glu Lys Asn Ile Ser Lys Tyr Lys Pro Glu Lys Asn Lys Val Tyr Ile 
        835                 840                 845             


Glu Glu Leu Arg Lys Ile Ser Tyr Ile Leu Lys Val Met Leu Glu His 
    850                 855                 860                 


Lys Glu Arg Val Ile Gln Lys His Tyr Leu Glu Ser Tyr Asp Glu Asp 
865                 870                 875                 880 


Ile Ser Ile Met Tyr Gly Lys Asp Ile Glu Lys Lys Asp Ile Lys Asp 
                885                 890                 895     


Ile Glu Ile Lys Ile Lys Asn Lys Asn Gln Glu Val Ile Asn Gln Pro 
            900                 905                 910         


Leu Tyr Lys Ser Gly Asn Asp Gly Asn Ser Ser Trp Ile Val Leu Tyr 
        915                 920                 925             


Gly Ile Glu Gln Ala Lys Arg Asn Gly Thr Phe Lys Phe Phe Glu Gly 
    930                 935                 940                 


Phe Phe Asn Leu Asn Glu Asp Ile Lys Leu Cys Lys Lys Asp Ile Lys 
945                 950                 955                 960 


Lys Tyr Glu Lys Leu Tyr Asn Glu Lys Glu Glu Asn Gln Lys Lys Val 
                965                 970                 975     


Asp Glu Tyr Ile Phe Tyr Glu Arg Asn Ser Tyr Ile Glu Lys Val Asn 
            980                 985                 990         


Asn Asn Ile Asn Ile Glu Lys Thr  Asn Asn Asn Lys Gln  Leu Phe Tyr 
        995                 1000                 1005             


Tyr Tyr  Lys Asn Met Ile Tyr  Gly Asp Gly Leu Lys  Lys Gly Tyr 
    1010                 1015                 1020             


Asp Phe  Ile Asn Asp Ile Tyr  Ser His Tyr Leu Ser  Trp Ala Tyr 
    1025                 1030                 1035             


Arg Ile  Glu Arg Asp Cys Lys  Ile Tyr Lys Ile Lys  Glu Tyr Glu 
    1040                 1045                 1050             


Asn Lys  Lys Asn Phe Asn Glu  Tyr Lys Phe Lys Glu  Tyr Lys Ser 
    1055                 1060                 1065             


Ile Lys  Asn Phe Arg Asn Glu  Ile Ala His Phe Asn  Tyr Phe Gln 
    1070                 1075                 1080             


Lys Thr  Asn Lys Ser Leu Leu  Glu Leu Leu Asn Asn  Phe Tyr Asp 
    1085                 1090                 1095             


Ile Phe  Asp Tyr Asn Leu Lys  Tyr Gln Arg Asp Val  Gln Lys Val 
    1100                 1105                 1110             


Ile Asn  Asn Ile Phe Glu Lys  Tyr Gln Val Ile Arg  Glu Asp Gly 
    1115                 1120                 1125             


Gly Pro  Val Ile Phe Tyr Cys  Lys Ile Glu Lys Lys  Leu Lys Leu 
    1130                 1135                 1140             


Ser Glu  Asn Ile Ile Pro Lys  Lys His Ser Lys Tyr  Pro Glu Ile 
    1145                 1150                 1155             


Lys Leu  Ile His Glu Lys Tyr  Val Glu Phe Phe Lys  Lys Leu Phe 
    1160                 1165                 1170             


Glu Tyr  Lys Lys 
    1175         


<210>  892
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  892

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Ser Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Val Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Thr Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Lys Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Val Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Lys Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Lys Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Val Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Leu Lys Glu Leu Lys Glu Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn Tyr Arg Met Gln Gln Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Lys Lys Asp Glu Lys Phe Asn Asp Lys Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Thr Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Glu Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Lys  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  893
<211>  1245
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  893

Met Lys Ile Ser Lys Val Asn His Val Lys Thr Gly Val Ser Ala Lys 
1               5                   10                  15      


Pro Ala Ile Glu Gly Gly Met Leu Tyr Asp Tyr Pro Ser Lys Glu Gly 
            20                  25                  30          


Gly Ser Lys Asp Leu Arg Lys His Ile Glu Glu Val Asn Arg Lys Ala 
        35                  40                  45              


Gln Ile Leu Tyr Asn Val Phe Asn Gln Val Lys Glu Lys Asp Lys Lys 
    50                  55                  60                  


Gln Asn Ser Val Lys Asp Ala Leu Lys Ile Ala Asn Ala Tyr Ile Asn 
65                  70                  75                  80  


Ser Thr Val Ile Phe Gly Ile Lys Lys Glu Phe Pro Glu Asn Lys Ile 
                85                  90                  95      


Cys Asn Asn Phe Ser Tyr Ala Val Asn Arg Pro Ile Arg Leu Gly Lys 
            100                 105                 110         


Glu Asn Val Phe Ile Thr Ser Ile Ser Val Ser Val Lys Glu Lys Ser 
        115                 120                 125             


Ala Lys Glu Ser Ala Glu Tyr Ile Val Asn Asn Tyr Leu Arg Asn Ser 
    130                 135                 140                 


Leu Arg Arg Asp Lys Arg Ala Ala Glu Thr Ile Val Arg Ile Leu Thr 
145                 150                 155                 160 


Ala Leu Tyr Asp Gly Lys Asn Tyr Glu Lys Leu Ile Lys Lys Ile Glu 
                165                 170                 175     


Arg Glu Asp Leu Ala Ala Val Val Ser Ala Val Ser Arg Asp Tyr Leu 
            180                 185                 190         


Lys Asp Gly Glu Leu Glu Lys Ile Ala Val Ser Ile Glu Lys Gln Lys 
        195                 200                 205             


Val Leu Val Gln Val Gly Lys Asp Gly Tyr Leu Ile Pro Ser Gly Ala 
    210                 215                 220                 


Glu His Glu Lys Lys Ala Tyr Ile Phe Asn Phe Met Lys Lys Tyr Ala 
225                 230                 235                 240 


Glu Ser Asp Glu Glu Gly Gln Arg Lys Met Leu Asn His Met Lys Asp 
                245                 250                 255     


Leu Ile Arg Leu Tyr Tyr Thr Glu Glu Glu Val Val Ser Ser Glu Ile 
            260                 265                 270         


Leu Asp Leu Ile Asn Ser Arg Asp Asn Thr Pro Phe Ser Gln Lys Asp 
        275                 280                 285             


Ile Ile Arg Ser Tyr Asn Glu Gln Ile Ala Glu Lys Val Ser Ala Phe 
    290                 295                 300                 


Leu Val Glu Arg Tyr Gln Lys Thr Leu Lys Asp Ala Lys Ser Glu Asp 
305                 310                 315                 320 


Glu Glu Gly Trp Val Arg Tyr Ile Ser Asp Lys Ala Glu Lys Leu Leu 
                325                 330                 335     


Ser Val Lys Asn Leu Thr Gln Asp Arg Ile His Cys Asp Tyr Leu Phe 
            340                 345                 350         


Lys Lys Thr Trp Glu Glu Trp Thr Ser Phe Ile Ala Lys Lys Tyr Ile 
        355                 360                 365             


Asp Leu Gly Lys Ala Thr Tyr Asn Phe Ala Met Gly Asp Ile Ser Lys 
    370                 375                 380                 


Val Ser Lys Gly Glu Ser Val Ala Phe Gly Thr Val Asn Glu Gly Phe 
385                 390                 395                 400 


Glu Thr Gly Ile Ser Ser Phe Asp Tyr Glu Arg Met Lys Ala Glu Asp 
                405                 410                 415     


Ser Leu Asn Arg Ala Met Ile Lys Tyr Ile Ser Phe Ala Val Asn Ile 
            420                 425                 430         


Phe Asp Ala Ser Val Arg Asn Pro Glu Gln Arg Thr Gly Gly Lys Glu 
        435                 440                 445             


Asp Ile Leu Leu Leu Lys Pro Glu Asn Ile Val Met Tyr Glu Asp Ala 
    450                 455                 460                 


Val Lys Arg Val Leu Arg Tyr Phe Gly Gly Ile Ser Lys Phe Ser Glu 
465                 470                 475                 480 


Ser Ser Leu Asp Val Ser Asp Lys Asn Gly Phe Phe Thr Ala Leu Lys 
                485                 490                 495     


Asp Glu Leu Tyr Ala Ala Arg Asn Tyr Ala Phe His Tyr Val Thr Gly 
            500                 505                 510         


Glu Ala Glu Lys Arg Glu Lys Pro Val Val Thr Thr Leu Leu Asp Thr 
        515                 520                 525             


Glu Tyr Met Leu Val Gly Ser Ile Phe Arg Lys Lys Tyr Phe Ser Asn 
    530                 535                 540                 


Asn Val Pro Met Phe Tyr Arg Thr Ala Asp Ile Asp Asn Leu Met Ser 
545                 550                 555                 560 


Arg Leu Tyr Lys Ser Asn Arg Val Ile Leu Ala Gln Met Pro Ser Phe 
                565                 570                 575     


Asn Lys Val Leu Ser Arg Asn Ala Val Val Asp Phe Ala Asn Ala Tyr 
            580                 585                 590         


Leu Ala Gly Asp Ser Lys Arg Glu Met Ser Gln Pro Glu Ile Ser Glu 
        595                 600                 605             


Gln Phe Arg Ser Ser Phe Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Tyr 
    610                 615                 620                 


Asp Phe Ile Leu Lys Glu Asp Leu Leu Glu Arg Phe Lys Asn Gly Val 
625                 630                 635                 640 


Glu Cys Ala Gln Ala Ser Ala Ile Lys Lys Glu Asn Asn Ser Arg Lys 
                645                 650                 655     


His Val Ala Met Lys Asn Ala Tyr Arg Asp Phe Met Ser Arg Ala Asp 
            660                 665                 670         


Lys Leu Thr Lys Thr Lys Gly Ile Thr Phe Gly Gln Phe Cys Gln Glu 
        675                 680                 685             


Ile Met Thr Glu Tyr Asn Gln Gln Asn Ser Gln Lys Gln Lys Lys Pro 
    690                 695                 700                 


Ser Ala Val Glu Lys Thr Tyr Val Val Lys Gly Gln Thr Arg Thr Ser 
705                 710                 715                 720 


Val Arg Glu Val Glu Asp Lys Glu Gln Ile Tyr Lys His Tyr Arg Thr 
                725                 730                 735     


Leu Leu Tyr Ala Gly Ile Arg Glu Ala Phe Leu Ile Tyr Leu Lys Glu 
            740                 745                 750         


Glu Ala Ala Phe Gly Phe Leu Arg Ser Pro Lys Asp Gly Arg Glu Lys 
        755                 760                 765             


Phe Arg Asp Leu Lys Glu Glu Asp Phe Ser Gln Gly Trp Thr Thr Glu 
    770                 775                 780                 


Cys Tyr Thr Lys Leu Lys Asp Ala Ile Ile Glu Asp Lys Glu Leu Ser 
785                 790                 795                 800 


Ser Trp Tyr Val Thr Ala His Phe Met Asn Gln Lys His Leu Asn His 
                805                 810                 815     


Leu Ile Gly Glu Ile Lys Asn Tyr Val Gln Phe Ile Asp Asp Ile Glu 
            820                 825                 830         


Lys Arg Ala Lys Val Thr Gly Asn Arg Val Cys Ser Thr Glu Glu Lys 
        835                 840                 845             


Met Gly Lys Phe Thr Ser Leu Leu Glu Val Leu Glu Phe Cys Lys Leu 
    850                 855                 860                 


Phe Cys Gly Gln Val Ser Asn Asn Leu Glu Asp Tyr Phe Ala Asn Asn 
865                 870                 875                 880 


Glu Glu Tyr Ala Lys Tyr Val Ala Gly Phe Val Asp Tyr Gly Gly Thr 
                885                 890                 895     


Ser Ala Ala Leu Leu Gln Ala Phe Cys Arg Glu Asn Lys Glu Leu Asn 
            900                 905                 910         


Tyr Tyr Asp Glu Leu Asn Pro Ile Pro Asn Arg Asn Ile Ile Leu Ser 
        915                 920                 925             


Leu Leu Tyr Gly Asn Thr Ala Val Leu Ser Ser Ser Met Lys Lys Val 
    930                 935                 940                 


Thr Leu Gln Glu Val Lys Gly Tyr Gln Lys Asn Lys Glu Ser Leu Ser 
945                 950                 955                 960 


Gly Val Phe Lys Asn Gly Ala Cys Lys Asp Glu Asn Glu Gln Arg Lys 
                965                 970                 975     


Met Ser Asn Tyr Gln Lys Gln Lys Asn Arg Ile Glu Phe Val Asp Val 
            980                 985                 990         


Leu Thr Leu Thr Glu Leu Leu Asn  Asp Leu Tyr Gly Gln  Leu Ile Ser 
        995                 1000                 1005             


Tyr Ser  Tyr Leu Arg Glu Arg  Asp Leu Met Phe Met  Gln Leu Gly 
    1010                 1015                 1020             


Phe Tyr  Tyr Thr Lys Leu Phe  His Thr Ser Ser Val  Pro Ala Gln 
    1025                 1030                 1035             


Asp Lys  Leu Arg Val Leu Ser  Gly Asp Cys Asp Ile  Lys Asp Gly 
    1040                 1045                 1050             


Ala Val  Leu Tyr Gln Ile Ala  Ala Met Tyr Ser Tyr  Asp Leu Pro 
    1055                 1060                 1065             


Ile Tyr  Gly Ile Ser Lys Gln  Gly Val Ala Val Arg  Lys Lys Ser 
    1070                 1075                 1080             


Gly Val  Ser Thr Gly Ala Lys  Leu Asn Gln Phe Ser  Thr Glu Tyr 
    1085                 1090                 1095             


Cys Gly  Gly Lys Trp Asp Ile  Tyr Thr Asn Gly Leu  Tyr Phe Phe 
    1100                 1105                 1110             


Glu Asp  Val Asp Gly Arg His  Lys Asp Tyr Val Glu  Val Arg Asn 
    1115                 1120                 1125             


Tyr Ile  Glu His Phe Lys Tyr  Phe Ala Asp His Lys  Lys Ser Ile 
    1130                 1135                 1140             


Leu Asp  Leu Tyr Ser Asp Leu  Tyr Asn Gly Phe Phe  Ser Tyr Asp 
    1145                 1150                 1155             


Thr Lys  Leu Lys Lys Ser Met  Ser Phe Val Leu Pro  Asn Ile Leu 
    1160                 1165                 1170             


Leu Ser  His Phe Val Asn Ala  Lys Leu Ser Tyr Glu  Lys Asp Val 
    1175                 1180                 1185             


Val Gln  Lys Asn Ser Glu Ser  Tyr Arg Arg Ala Arg  Ile Val Ile 
    1190                 1195                 1200             


Arg Glu  Lys Asp Ile Lys Ser  Asp Phe Leu Thr Tyr  Lys Asn Lys 
    1205                 1210                 1215             


Glu Asn  Ser Lys Ala Phe Tyr  Val Pro Ala Arg Asn  Asp Val Phe 
    1220                 1225                 1230             


Leu Lys  Glu Val Leu Asp Met  Ile Ser Phe Lys Arg  
    1235                 1240                 1245 


<210>  894
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  894

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  895
<211>  1202
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  895

Met Arg Ile Ile Arg Pro Tyr Gly Arg Ser Ala Thr Arg Pro Gly Ala 
1               5                   10                  15      


Gly Asp Gly Ala Ala Arg Val Arg Val Leu Arg Leu Arg Glu Val Pro 
            20                  25                  30          


Gly Gly Gly Gly Ser Ala Glu Arg Glu Ile Ala Pro Phe Ala Ser Ser 
        35                  40                  45              


Glu Asp Ala Leu Val Ile Ala Gln Trp Ile Ser Thr Ile Asp Lys Ile 
    50                  55                  60                  


Ala Thr Lys Pro Lys Gly Asp Lys Lys Pro Thr Gln Ala Gln Arg Asp 
65                  70                  75                  80  


Leu Arg Asp Leu Arg Glu Arg Leu Gly Lys Ala Gly Trp Asp Phe Ile 
                85                  90                  95      


Val Glu Lys Lys Leu Leu Pro Gly Leu Ala Ala Asp Ala Asp Gly Tyr 
            100                 105                 110         


Phe Lys Lys Leu Trp Asp Phe Lys Ile Ala Pro Tyr Pro Asp Gly Thr 
        115                 120                 125             


Tyr Thr Pro Pro Glu Gly Lys Gln Pro Pro Ser Pro Lys Gly Arg Trp 
    130                 135                 140                 


Tyr Ala Arg Phe Ala Gly Asp Val Ala Pro Glu Asp Val Asn Ala Ala 
145                 150                 155                 160 


Glu Val Ala Ala Ser Ile His Glu His Leu Tyr Thr Ala Ala Tyr Arg 
                165                 170                 175     


Met Ala Asp Gly Arg Pro Asn His Pro Met Gly Arg Ile Glu Ala Arg 
            180                 185                 190         


Ala Ala Ser Ile Ala Ala Asn Ser Leu Ser Leu Glu Arg Ala Gly Ala 
        195                 200                 205             


Arg Glu Arg Thr Trp Thr Asp Asp Asp Arg Arg Ser Tyr Glu Glu Lys 
    210                 215                 220                 


Gly Gly Asn Ile Ala Glu Gln Ile Arg Gln Ala Ala Thr Ala Gln Glu 
225                 230                 235                 240 


Ser Ala His Arg Arg Val Gly Val Asp Val Ala Ala Arg Val Leu His 
                245                 250                 255     


Glu Ala Trp Pro Lys Leu Phe Asp Gly Glu Ala Leu Ser Phe Lys Asp 
            260                 265                 270         


Ala Arg Asp Arg Ser Pro Gly Leu Val Asp Leu His Glu Ala Ile Arg 
        275                 280                 285             


Asp Arg Tyr Ser Arg Thr Leu Lys Arg His Gly Lys Asp Gln Lys Ala 
    290                 295                 300                 


His Gly Glu His Arg Arg Lys Val Ser Thr Leu Leu Pro Ala Thr Met 
305                 310                 315                 320 


Glu Gly Leu Phe Ala Leu Val Asp Ser Thr Leu Glu Asn Arg Asp Leu 
                325                 330                 335     


Ala Ala Leu Val Arg Leu Gly Lys Val Ile His Tyr Gln Ala Ala Thr 
            340                 345                 350         


Ala Gln Asp Thr Pro Ala Asp Val Val Asn His Trp Pro Ala Ala Asp 
        355                 360                 365             


Ala Ile Ala Ala Ser His Tyr Trp Ser Ser Asp Gly Gln Ala Glu Ile 
    370                 375                 380                 


Lys Arg Asn Glu Ala Phe Val Arg Ile Trp Arg His Ser Leu Ala Leu 
385                 390                 395                 400 


Ala Arg Gln Thr Leu Val Asp Trp Ala Asp Pro Gly Gly Arg Ile Asn 
                405                 410                 415     


Thr Asp Ile Leu Leu Gly Gly Gly Ile Thr Gln Ala Ile Gly Thr Cys 
            420                 425                 430         


Phe Asp Pro Arg His His Glu Arg Lys Leu Lys Leu Leu Phe Gly Ser 
        435                 440                 445             


Arg Ser Ala Leu Phe Thr Asp Ser Arg Asp Asp Ala Val Lys Lys Glu 
    450                 455                 460                 


Thr Leu Arg Val Ala Leu Lys Gly Val Ala Asp Leu Arg His Ser Ala 
465                 470                 475                 480 


Phe His Phe Lys Gly Leu Gly Gly Phe Ser Gln Ala Leu His Glu Leu 
                485                 490                 495     


Ser Ala Ser Gly Asp Val Leu Ala Lys Ile Arg Asp Leu Trp Val Glu 
            500                 505                 510         


Asp Ile Gln Gly Arg Ala Glu Arg Leu Arg Gln Thr Met Val Gly Ala 
        515                 520                 525             


His Phe Asp Cys Phe Phe Lys Lys Glu Gln Asn Arg Lys Leu Phe Glu 
    530                 535                 540                 


Ala Val Ile Gly Ala Ala Gly Asp Val Pro Leu Pro Arg Phe Arg Arg 
545                 550                 555                 560 


Leu Leu Glu Arg Ala His Asn Ile Ala Gly Thr Gly Ala Ile Lys Leu 
                565                 570                 575     


Lys Leu Pro Pro Pro Ala Asn Arg Leu Ala Leu Gln Glu Gln Pro Ala 
            580                 585                 590         


Arg Leu Cys Gln Tyr Val Ala Leu Lys Leu Leu Tyr Glu His Pro Phe 
        595                 600                 605             


Arg Gly Trp Leu Gly Gly Leu Asp Ala Ala Thr Ile Asn Gly Phe Ile 
    610                 615                 620                 


Asp Arg Ala Val Glu Arg Thr Glu Gln Ala Ala Arg Ser Ile Asn Ala 
625                 630                 635                 640 


Gly Arg Asn Lys Asp Arg Arg Ala Leu Ile Thr Ala Lys Ala Arg Ala 
                645                 650                 655     


Leu Gly Arg Leu Ala Asp Gly Glu Arg Ile Gln Asp Phe Leu Glu Arg 
            660                 665                 670         


Leu Thr Ala Glu Thr Ala Ser Glu Met Arg Val Gln Arg Gly Tyr Ala 
        675                 680                 685             


Ser Asp Ala Glu Ser Ala Arg Glu Gln Ala Gly Tyr Ile Asp Glu Leu 
    690                 695                 700                 


Leu Cys Asp Val Leu Ala Gln Ala Phe Glu Thr Tyr Leu Asp Gln Gln 
705                 710                 715                 720 


Gly Phe Arg Phe Val Thr His Leu Arg Pro Asp Ala Ala Gln Pro Gly 
                725                 730                 735     


Ser Pro Val Cys Ala Leu Asp Ser Leu Ser Pro Ala Ala Val Asp Thr 
            740                 745                 750         


Thr Val Ala Asp Trp Gln Ala Ile Leu Tyr Phe Leu Leu His Leu Val 
        755                 760                 765             


Pro Val Glu Glu Ala Gly Arg Leu Leu His Gln Ile Arg Lys Trp Asp 
    770                 775                 780                 


Ile Leu Ala Gly Lys Ala Glu Gly Ala Pro Leu Arg Thr Thr Lys Ser 
785                 790                 795                 800 


Asn Val Ala Pro Ile Thr Lys Ala Leu Glu Leu Tyr Leu Asp Met His 
                805                 810                 815     


Asp Ala Lys Phe Thr Gly Gly Glu Ala Leu Gln Val Ile Asp Asp Phe 
            820                 825                 830         


Lys Gln Leu Phe Ala Asn Lys Ala Leu Phe Asp Glu Val Phe Pro Ala 
        835                 840                 845             


Thr Ala Ala Gly Ala Glu Asp Glu Arg Leu Pro Leu Arg Gly Leu Arg 
    850                 855                 860                 


Glu Ile Leu Arg Phe Gly Asn Leu Glu Arg Leu Leu Pro Ile Phe Gln 
865                 870                 875                 880 


Gln His Arg Ile Ser Gln Val Asp Val Glu Lys Val Arg Ala Asp Glu 
                885                 890                 895     


Asn Ala Asn Ser Ser Ser Ser Pro Ile Ala Asp Ala Gln Ala Lys Arg 
            900                 905                 910         


Glu Thr Leu His Glu Lys Trp Ser Lys Lys Arg Lys Glu Phe Ser Glu 
        915                 920                 925             


Ser Asp Arg Arg Ala Tyr Val Glu Ala Leu Ala Phe Val Met Val His 
    930                 935                 940                 


Arg His Leu Ala Ala Gln Val Arg Leu Val Asn His Val Arg Leu His 
945                 950                 955                 960 


His Leu Met Met Ala Val Leu Gly Arg Leu Val Asp Phe Ser Gly Leu 
                965                 970                 975     


Trp Glu Arg Asp Leu Tyr Phe Ala Met Leu Ala Leu Leu Ser Arg Gln 
            980                 985                 990         


Gly Leu Ser Pro Gln Gln Val Phe  Gln Gly Asp Gly Leu  Asn Lys Leu 
        995                 1000                 1005             


Glu Arg  Gly Gln Val Val Glu  Ala Cys Arg Asn Leu  Asp Leu Thr 
    1010                 1015                 1020             


Val Arg  Ala Asp Leu Ala Pro  His Phe Gly Ser Pro  Asp Ser Asp 
    1025                 1030                 1035             


Phe Glu  Ala Leu Val Arg Ile  Arg Asn Thr Phe Ala  His Phe Asn 
    1040                 1045                 1050             


Met Leu  Arg Gly Asn Ala Ala  Pro Asp Leu Thr Lys  Cys Ile Asn 
    1055                 1060                 1065             


Asp Ala  Arg Glu Leu Met Ala  Tyr Asp Arg Lys Leu  Lys Asn Ala 
    1070                 1075                 1080             


Val Ala  Gln Ala Val Ile Glu  Leu Leu Ala Arg Asp  Gly Phe Ala 
    1085                 1090                 1095             


Leu Arg  Trp Thr Met Asp Ala  Thr Ser Ala Asp His  Met Leu Asn 
    1100                 1105                 1110             


Cys Ala  Arg Val Ala Thr Arg  Gln Ala Lys His Leu  Gly Ser Glu 
    1115                 1120                 1125             


Ser Ile  Arg Glu Ser Leu His  Gly Pro Cys Phe Val  Glu Met Val 
    1130                 1135                 1140             


Ala Val  Leu Phe Gly Gly Gln  Met Ser Ala Ser Asp  Cys Asp Val 
    1145                 1150                 1155             


Ser Gln  Leu Pro Leu Asp Leu  Ile Asp Trp Glu Lys  Val Gly Arg 
    1160                 1165                 1170             


Pro Arg  Glu Gly Gly Ala Gly  Lys Arg Arg Ile Pro  Gln Gly Lys 
    1175                 1180                 1185             


Ala His  Pro Gly Arg Arg His  Arg Arg Lys Val Pro  Arg Glu 
    1190                 1195                 1200         


<210>  896
<211>  949
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  896

Met Pro His Gln Lys Lys Met Ala Glu Arg Ile Lys Phe Val Asn Tyr 
1               5                   10                  15      


Gly Tyr Tyr Leu Arg Leu Lys Lys Asn Cys Ala Asp Ser Phe Glu Tyr 
            20                  25                  30          


Tyr Trp Cys Asp Tyr Ile Lys Glu Phe Ile Glu Glu Asn Tyr Val Thr 
        35                  40                  45              


Lys Ile Lys Glu Ala Lys Gly Lys Asn Gly Arg Gln Leu Thr Glu Glu 
    50                  55                  60                  


Asn Cys Asn Ser Glu Ala Met Leu Ser Lys Cys Trp His Asp Met Ile 
65                  70                  75                  80  


Arg His Met Cys Ala Lys Tyr Met Asp Leu Gly Lys Ala Val Tyr His 
                85                  90                  95      


Phe Met Leu Pro Gly Lys Ala Glu Gly Asn Asp Leu Cys Leu Asp Arg 
            100                 105                 110         


Leu Asn Asp Ser Phe Ser Lys Gly Ile Thr Ser Phe Asp Tyr Glu Asn 
        115                 120                 125             


Ile Lys Ala Glu Glu Asn Leu Gln Lys Ala Met Phe Gly Val Leu Val 
    130                 135                 140                 


Ser Gly Thr Phe Asn Phe Ser Arg Ser Val Ala Asp Tyr Ser Gly Pro 
145                 150                 155                 160 


Ala Ala Ala Lys Leu Ala Lys Glu Leu Arg Ala Glu Gly Lys Thr Leu 
                165                 170                 175     


Asn Glu Asp Val Leu Met Val Asp Glu Ala His Leu Lys Ala Ile Leu 
            180                 185                 190         


Tyr Ser Asp Ala Lys Arg Lys Leu Leu Arg Tyr Phe Gly Gly Ser Ser 
        195                 200                 205             


Ala Cys Glu Ala Leu Gly Leu Asp Lys Asp Lys Met Val Leu Glu Phe 
    210                 215                 220                 


Arg Gln Ile Phe Arg Gly Leu Arg Asn Ser Ala Phe His Tyr Thr Asp 
225                 230                 235                 240 


Gly Lys Lys Ala Asp Ile Lys Phe Asp Val Thr Arg Gln Leu Trp Ile 
                245                 250                 255     


Gln Asp Val Gln Ala Asn Lys Gln Leu Ile Leu Asp Lys Tyr Tyr Ser 
            260                 265                 270         


Asn Asn Val Cys Arg Tyr Tyr Lys Pro Glu Met Val Lys Lys Leu Ile 
        275                 280                 285             


Gly Asn Leu Tyr His Gly Tyr Val Glu Gln Glu Ala Gln Ile Pro Ala 
    290                 295                 300                 


Phe Arg Thr Val Trp Lys Arg Lys Asp Phe Ala Lys Tyr Leu Asn Asp 
305                 310                 315                 320 


Ser Asn Phe Leu Pro Val Asn Ile Lys Asn Asp Val Lys Glu Arg Thr 
                325                 330                 335     


Val Phe Glu Gly Ala Leu Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg 
            340                 345                 350         


Lys Tyr Thr Val Gly Gln Asp Ala Pro Lys Tyr Phe Phe Glu Ala Val 
        355                 360                 365             


Arg Ala Tyr Ser Asp Glu His Ala Lys Asn Lys Gln Asp Pro Tyr Ala 
    370                 375                 380                 


Asn Gln Ala Lys Asn Phe Trp Asp Tyr Val Glu Lys Leu Gln Lys Ser 
385                 390                 395                 400 


Tyr Glu Lys Gly Thr Leu Thr Phe Gly Ala Val Cys Gln Thr Ile Met 
                405                 410                 415     


Thr Glu Phe Val Gln Gln Asn Ser Lys Ala Thr Glu Lys Glu Gly Glu 
            420                 425                 430         


Ile Tyr Gln His Phe Lys Val Leu Phe Pro Leu Cys Met Gln Arg Gly 
        435                 440                 445             


Phe Glu Lys Tyr Val Lys Glu Lys His Gly Tyr Leu Leu Lys Pro Trp 
    450                 455                 460                 


Leu Asp Thr Val Val Arg Glu Asn Val Leu Gln Asp Ala Ala Ile Thr 
465                 470                 475                 480 


Cys Phe Asp Asp Leu Met Arg Asp Ala Glu Asp Arg Glu Tyr Ser Trp 
                485                 490                 495     


Tyr Val Val Ala His Phe Ile His Pro Lys Lys Leu Asn His Phe Val 
            500                 505                 510         


Gly Ala Leu Lys Asp Tyr Leu Gln Phe Lys Gln Asp Ile Phe Arg Arg 
        515                 520                 525             


Cys Ser Phe Ala Asn Ile Tyr Ser Glu Gly Glu Leu Ser Gln Lys Lys 
    530                 535                 540                 


Ala Met Leu Ala Glu Lys Glu Ala Glu Ile Ser Glu Ile Leu Arg Val 
545                 550                 555                 560 


Met Glu Phe Val Arg Gly Ile Thr Gly Arg Val Ser Lys Thr Phe Ser 
                565                 570                 575     


Asp Tyr Tyr Glu Asn Glu Glu Val Tyr Ala Asn Tyr Leu Gly Lys Tyr 
            580                 585                 590         


Ile Asp Phe Pro Lys Thr Asp Gly Ile Ser Val Phe Glu Ser Phe Arg 
        595                 600                 605             


Asp Phe Cys Thr Asn Thr Leu Pro Asp Gly Asn Val Leu Asp Val Tyr 
    610                 615                 620                 


Met Asp Glu Lys Asn Pro Arg Leu Leu Lys Asn Val Glu Leu Ala Arg 
625                 630                 635                 640 


Met Tyr Ala Gly Gly Asp Val Ala Leu Lys Lys Arg Lys Arg Ile Thr 
                645                 650                 655     


Ala Lys Asp Leu Gln Arg Tyr Tyr Gly Asn Glu Val Ala Val Gln Lys 
            660                 665                 670         


Ile Leu Gln Lys Gly Leu Cys Ser Thr Arg Glu Glu Gln Gln Arg Val 
        675                 680                 685             


Leu Glu Gln Gln Asn Leu Arg Gly Arg Ile Thr Leu Asn Asp Val Thr 
    690                 695                 700                 


Glu Ile Gln Glu Ile Ile Ser Asp Met Leu Ser Gln Leu Val Thr Phe 
705                 710                 715                 720 


Ser Tyr Phe Arg Glu Arg Asp Gln Met Tyr Leu Leu Leu Gly Phe Tyr 
                725                 730                 735     


Tyr Met Ala Leu Gln Thr Asn Arg Gly Ser Ser Trp Gly Asn Glu Thr 
            740                 745                 750         


Ile Asp Phe Cys Ala Gly Lys Lys Ile Ser Ile Lys Gln Gly Trp Val 
        755                 760                 765             


Leu His Gln Val Arg Ser Val Phe Thr Tyr Gly Leu Lys Leu Tyr Ser 
    770                 775                 780                 


Glu Leu Asp Glu Lys Gly Val Gly Gly Gln Leu Ser Ser Lys Ile Val 
785                 790                 795                 800 


Ala Phe Glu Arg Val His Arg Thr Ser Leu Ala Cys Ala Leu Arg Leu 
                805                 810                 815     


Phe Met Asp Glu Asn Cys Ser Arg Arg Ala Val Asp Val Arg Asn Tyr 
            820                 825                 830         


Val Asp His Phe Lys Tyr Tyr Phe Lys Ala Asp Arg Ser Ile Met Glu 
        835                 840                 845             


Leu Tyr Ser Ala Tyr Tyr Asp Cys Phe Phe Asp Tyr Ser Thr Lys Met 
    850                 855                 860                 


Arg Lys Ser Val Leu Leu Asn Phe Ile Ser Ile Leu Glu Arg His Phe 
865                 870                 875                 880 


Val Val Ser Lys Leu Arg Val Asn Cys Leu Glu Glu Arg Cys Ser Val 
                885                 890                 895     


Ser Phe Ala Glu Ser Leu Lys Ser Glu Lys Phe Thr Tyr Lys Leu Glu 
            900                 905                 910         


Ala Asp Ala Asn Lys Lys Ser Lys Glu Gln Thr Val Glu Phe Pro Ala 
        915                 920                 925             


Arg Asp Lys Glu Phe Leu Glu Ser Leu Gln Ala Glu Leu Glu Tyr Lys 
    930                 935                 940                 


Glu Gly Tyr Asn Ser 
945                 


<210>  897
<211>  1130
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  897

Met Lys Val Ser Lys Val Lys Val Lys Val Gly Ala Gly Arg Ser Ser 
1               5                   10                  15      


Glu Arg Met Val Phe Met Arg Arg Thr Ser Lys Ile Gly Ser Leu Val 
            20                  25                  30          


Tyr Glu Asp Glu Gln Arg Asn Gly Lys Pro Glu Thr Asp Asp Lys Thr 
        35                  40                  45              


Thr Ser Ile Leu Pro Asp Lys Lys Arg Asp Ser Phe Ile Leu Ser Ile 
    50                  55                  60                  


Val Asn Lys Thr Ile Pro Lys Lys Glu Ile Val Lys Lys Asn Leu Gly 
65                  70                  75                  80  


Lys Gly Phe Val Asn Glu Tyr Tyr Asn Ala Ile Ala Gly Ile Ile Asp 
                85                  90                  95      


Ser Phe Leu Glu Lys Lys Ile Val Asp Arg Lys His Tyr Ile Ile Val 
            100                 105                 110         


Asn Lys Leu Thr Glu Glu Glu Ile Lys Gln Tyr Leu Asn His Arg Phe 
        115                 120                 125             


Gln Glu Ala Asn Tyr Lys Tyr Val Arg Asp Lys Glu Glu Val Asn Phe 
    130                 135                 140                 


Asn Leu Pro Lys Leu Leu Lys Glu Ser Ala Lys Ser Asn Ser Thr Ala 
145                 150                 155                 160 


Pro Leu Gln Pro Tyr Lys Glu Trp Ala Glu Trp His Ile Glu Thr Lys 
                165                 170                 175     


Ser Val Arg Leu Ile Arg Ser Ile Gln Asn Asn Arg Leu Val Ile Asp 
            180                 185                 190         


Thr Gln Glu Glu Ala Glu Asn Met Ser Pro Arg Lys Arg Ala Leu Leu 
        195                 200                 205             


Lys Trp Glu Asn Glu Phe Leu Leu Ser His Lys Leu Asp Leu Gln Asp 
    210                 215                 220                 


Val Glu Lys Thr Tyr Leu Ile Asp Asp Leu Ile His Ala Leu His Glu 
225                 230                 235                 240 


Val Thr Tyr Thr Thr Asn Asp Lys Gly Phe Ile Asn Gly Asn Glu Tyr 
                245                 250                 255     


His Arg Phe Leu Lys Lys Ala Leu Gln Ser His Gln Gln Asn Ile Phe 
            260                 265                 270         


Gly Ser Arg Glu Thr Pro Asn Lys Val Asn Arg Glu Asn Ala Glu Leu 
        275                 280                 285             


Tyr Ser Tyr Asn Met Glu Val Val Lys Tyr Leu Glu His Tyr Phe Pro 
    290                 295                 300                 


Ile Lys Lys Thr Asn Arg Arg Asn Thr Leu Asp Thr Lys Asp Tyr Tyr 
305                 310                 315                 320 


Leu Asn Gly Ile Asn Ile Lys Asp Arg Val Arg Lys Gln Leu Glu Asn 
                325                 330                 335     


Ala Val Arg Asn Asn Leu Val Arg Gln Gly Lys Tyr Thr Leu His Thr 
            340                 345                 350         


Leu Thr Thr Asp Thr Ala Asn Ser Asp Asn Leu Ser Lys Ile Lys Ala 
        355                 360                 365             


Asp Glu Gly Phe Ala Leu Thr Met Leu Asn Gln Cys Ala Phe Ala Ala 
    370                 375                 380                 


Asn Asn Val Arg Asn Ile Ile Asp Pro Thr Gln Val Glu Asp Ile Leu 
385                 390                 395                 400 


Leu Asp Arg Pro Phe Asn Glu Ser Leu Glu Lys Phe Asn Ser Ala Gln 
                405                 410                 415     


Met Leu His Leu Ser Ser Phe Phe Asp Val Lys Glu Phe Asn Glu Pro 
            420                 425                 430         


Leu Arg Ala Ile Arg Asp Ala Val Ala Lys Ile Arg His Asn Ile Ile 
        435                 440                 445             


His Tyr Lys Val Asn Ala Leu Asn Val Ile Phe Lys Ile Glu Thr Phe 
    450                 455                 460                 


Gly Ser Thr Glu Lys Gln Tyr Lys Asp Thr Ile Phe Gly Ser Leu Leu 
465                 470                 475                 480 


Gln Ala Asp Met Met Asn Val Ser Glu Ser Leu Ala Lys Gln Leu Met 
                485                 490                 495     


Thr Gly Asn Val Leu Glu Tyr Tyr Pro Met Leu Glu Leu Lys Ser Phe 
            500                 505                 510         


Phe Ser Lys Asn Ser Ile Ser Leu Tyr Arg Ser Val Ile Pro Phe Ala 
        515                 520                 525             


Pro Gly Phe Lys Arg Val Met Lys Lys Gly Glu Asn Tyr Gln Asn Ala 
    530                 535                 540                 


Asn Asn Lys Asp Asp Lys Ser Lys Tyr Tyr Asn Leu Lys Ile Glu Ser 
545                 550                 555                 560 


Phe Leu Pro Gln Glu Ser Phe Thr Lys Glu Ala Tyr Asp Ala Arg Tyr 
                565                 570                 575     


Phe Leu Leu Lys Leu Ile Tyr Asn Asn Ile Phe Leu Pro Lys Phe Thr 
            580                 585                 590         


Glu Ser Thr Asp Trp Phe Lys Ser Thr Val Asn Gly Val Ile Ala Leu 
        595                 600                 605             


Asn Arg Glu Glu Asn Val Arg Lys Gly Lys Lys His Lys Ile Ala Phe 
    610                 615                 620                 


Ala Glu Ile Arg Leu Met Asp Ser Arg Asp Thr Ile Gly Thr Tyr Ala 
625                 630                 635                 640 


Ala Tyr Leu Gln Ser Cys Ala Ile Ile Glu Ala Asn Lys Lys Pro Asp 
                645                 650                 655     


Ala Ala Lys Asp Glu Thr Val Leu Leu Asn Phe Glu Lys Leu Ile Leu 
            660                 665                 670         


Gln Ile Phe Ile Lys Gly Phe Asp Asp Phe Leu Arg Arg Tyr Gly Met 
        675                 680                 685             


Leu Lys Phe Val Gln Gln Pro Ser Leu Gln Phe Lys Ser Gly Ala Lys 
    690                 695                 700                 


Asp Glu Thr Lys Gln Arg Lys Asp Trp Ala Lys Glu Val Glu Gly Ser 
705                 710                 715                 720 


Leu His Ala Pro Val Asn Asp Ile Asn Pro Thr Glu Ser Ser His Ile 
                725                 730                 735     


Ser Phe Tyr Val Phe Cys Lys Leu Leu Asp Ala Pro His Leu Asn Asp 
            740                 745                 750         


Leu Arg Asn Glu Leu Ile Lys Tyr Tyr Arg Ser Gln Ser His Arg Pro 
        755                 760                 765             


Gln Lys Ile Lys Asn Ile Lys Tyr Leu Leu Ser Ile Ile Glu Leu Cys 
    770                 775                 780                 


Leu Leu Ser Val Asp Ala Ser Glu Leu Asn Lys Leu Phe Thr Asp Ala 
785                 790                 795                 800 


Asp Asn Ser Ile Asn Asp Arg Leu Leu Ala Phe Leu Glu Lys Asn Lys 
                805                 810                 815     


Thr Val Ala Asp Tyr Glu Asp Leu Tyr Thr Gln Ser Asp Asn Glu Thr 
            820                 825                 830         


Met Val Leu His Arg Thr Ile Ala Lys Ala Tyr Lys Tyr Gly Thr Arg 
        835                 840                 845             


Lys Val Leu Glu Gln Val Ile Asp Ser Asp Pro Ser Tyr Arg Val Thr 
    850                 855                 860                 


Val Ser Glu Tyr Glu Glu Trp Lys Asn Leu Lys Glu Asn Val Glu Glu 
865                 870                 875                 880 


Trp Ile Ala Cys Arg Glu Lys Leu His Ala Lys Trp Val Lys Val Glu 
                885                 890                 895     


Arg Val Pro Lys Met Lys Glu Gly Glu Met Lys Asp Asp Met Lys Glu 
            900                 905                 910         


Tyr Val Glu Val Cys Ser Thr Ile Asp Arg Tyr Asn Trp Leu Asp Asn 
        915                 920                 925             


Lys Val His Leu Glu His Ile Asn Lys Leu His Asn Leu Thr Ile Asp 
    930                 935                 940                 


Leu Leu Gly Arg Met Ala Gly Phe Asn Thr Leu Phe Glu Arg Asp Leu 
945                 950                 955                 960 


Gln Tyr Tyr Cys Asn Cys Asn Glu Lys Val Arg Ser Leu Leu Lys Pro 
                965                 970                 975     


Glu Ser Ser Glu Gly Phe Asp Phe Ser Lys Gly Leu Pro Lys Phe Thr 
            980                 985                 990         


Glu Glu Gln Asn Ser Ile Leu Phe  Gln Thr Phe Leu Val  Glu Gly Tyr 
        995                 1000                 1005             


Arg Asp  Thr Arg Asn Phe Val  Ala His Phe Asn Phe  Leu Asn Ser 
    1010                 1015                 1020             


Phe Glu  Asp Ser Tyr Ser Lys  Asn Arg Tyr Ser Leu  Ile Asp Val 
    1025                 1030                 1035             


Ile Asn  Arg Leu Arg Lys Gln  Phe Lys Tyr Asp Arg  Lys Leu Lys 
    1040                 1045                 1050             


Asn Ala  Val Ser Lys Ala Ile  Ile Lys Leu Phe Glu  Lys His Gly 
    1055                 1060                 1065             


Met Val  Leu Thr Phe Ser Phe  Glu Gly Asp His Glu  Leu Val Val 
    1070                 1075                 1080             


Lys Asp  Val Phe Pro Arg Lys  Ile Ile His Phe Ser  Lys Leu Lys 
    1085                 1090                 1095             


Leu Asp  Lys Lys Ile Glu Gln  Lys Pro Lys Val Glu  Thr Asp Met 
    1100                 1105                 1110             


Val Pro  Lys Glu Phe Cys Ala  Met Cys Lys Phe Leu  Leu Glu Leu 
    1115                 1120                 1125             


Lys Lys  
    1130 


<210>  898
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  898

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  899
<211>  949
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  899

Met Pro His Gln Lys Lys Met Ala Glu Arg Ile Lys Phe Val Asn Tyr 
1               5                   10                  15      


Gly Tyr Tyr Leu Arg Leu Lys Lys Asn Cys Ala Asp Ser Phe Glu Tyr 
            20                  25                  30          


Tyr Trp Cys Asp Tyr Ile Lys Glu Phe Ile Glu Glu Asn Tyr Val Thr 
        35                  40                  45              


Lys Ile Lys Glu Ala Lys Gly Lys Asn Gly Arg Gln Leu Thr Glu Glu 
    50                  55                  60                  


Asn Cys Asn Ser Glu Ala Met Leu Ser Lys Cys Trp His Asp Met Ile 
65                  70                  75                  80  


Arg His Met Cys Ala Lys Tyr Met Asp Leu Gly Lys Ala Val Tyr His 
                85                  90                  95      


Phe Met Leu Pro Gly Lys Ala Glu Gly Asn Asp Leu Cys Leu Asp Arg 
            100                 105                 110         


Leu Asn Asp Ser Phe Ser Lys Gly Ile Thr Ser Phe Asp Tyr Glu Asn 
        115                 120                 125             


Ile Lys Ala Glu Glu Asn Leu Gln Lys Ala Met Phe Gly Val Leu Val 
    130                 135                 140                 


Ser Gly Thr Phe Asn Phe Ser Arg Ser Val Ala Asp Tyr Ser Gly Pro 
145                 150                 155                 160 


Ala Ala Ala Lys Leu Ala Lys Glu Leu Arg Ala Glu Gly Lys Thr Leu 
                165                 170                 175     


Asn Glu Asp Val Leu Met Val Asp Glu Ala His Leu Lys Ala Ile Leu 
            180                 185                 190         


Tyr Ser Asp Ala Lys Arg Lys Leu Leu Arg Tyr Phe Gly Gly Ser Ser 
        195                 200                 205             


Ala Cys Glu Ala Leu Gly Leu Asp Lys Asp Lys Met Val Leu Glu Phe 
    210                 215                 220                 


Arg Gln Ile Phe Arg Gly Leu Arg Asn Ser Ala Phe His Tyr Thr Asp 
225                 230                 235                 240 


Gly Lys Lys Ala Asp Ile Lys Phe Asp Val Thr Arg Gln Leu Trp Ile 
                245                 250                 255     


Gln Asp Val Gln Ala Asn Lys Gln Leu Ile Leu Asp Lys Tyr Tyr Ser 
            260                 265                 270         


Asn Asn Val Cys Arg Tyr Tyr Lys Pro Glu Met Val Lys Lys Leu Ile 
        275                 280                 285             


Gly Asn Leu Tyr His Gly Tyr Val Glu Gln Glu Ala Gln Ile Pro Ala 
    290                 295                 300                 


Phe Arg Thr Val Trp Lys Arg Lys Asp Phe Ala Lys Tyr Leu Asn Asp 
305                 310                 315                 320 


Ser Asn Phe Leu Pro Val Asn Ile Lys Asn Asp Val Lys Glu Arg Thr 
                325                 330                 335     


Val Phe Glu Gly Ala Leu Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg 
            340                 345                 350         


Lys Tyr Thr Val Gly Gln Asp Ala Pro Lys Tyr Phe Phe Glu Ala Val 
        355                 360                 365             


Arg Ala Tyr Ser Asp Glu His Ala Lys Asn Lys Gln Asp Pro Tyr Ala 
    370                 375                 380                 


Asn Gln Ala Lys Asn Phe Trp Asp Tyr Val Glu Lys Leu Gln Lys Ser 
385                 390                 395                 400 


Tyr Glu Lys Gly Thr Leu Thr Phe Gly Ala Val Cys Gln Thr Ile Met 
                405                 410                 415     


Thr Glu Phe Val Gln Gln Asn Ser Lys Ala Thr Glu Lys Glu Gly Glu 
            420                 425                 430         


Ile Tyr Gln His Phe Lys Val Leu Phe Pro Leu Cys Met Gln Arg Gly 
        435                 440                 445             


Phe Glu Lys Tyr Val Lys Glu Lys His Gly Tyr Leu Leu Lys Pro Trp 
    450                 455                 460                 


Leu Asp Thr Val Val Arg Glu Asn Val Leu Gln Asp Ala Ala Ile Thr 
465                 470                 475                 480 


Cys Phe Asp Asp Leu Met Arg Asp Ala Glu Asp Arg Glu Tyr Ser Trp 
                485                 490                 495     


Tyr Val Val Ala His Phe Ile His Pro Lys Lys Leu Asn His Phe Val 
            500                 505                 510         


Gly Ala Leu Lys Asp Tyr Leu Gln Phe Lys Gln Asp Ile Phe Arg Arg 
        515                 520                 525             


Cys Ser Phe Ala Asn Ile Tyr Ser Glu Gly Glu Leu Ser Gln Lys Lys 
    530                 535                 540                 


Ala Met Leu Ala Glu Lys Glu Ala Glu Ile Ser Glu Ile Leu Arg Val 
545                 550                 555                 560 


Met Glu Phe Val Arg Gly Ile Thr Gly Arg Val Ser Lys Thr Phe Ser 
                565                 570                 575     


Asp Tyr Tyr Glu Asn Glu Glu Val Tyr Ala Asn Tyr Leu Gly Lys Tyr 
            580                 585                 590         


Ile Asp Phe Pro Lys Thr Asp Gly Ile Ser Val Phe Glu Ser Phe Arg 
        595                 600                 605             


Asp Phe Cys Thr Asn Thr Leu Pro Asp Gly Asn Val Leu Asp Val Tyr 
    610                 615                 620                 


Met Asp Glu Lys Asn Pro Arg Leu Leu Lys Asn Val Glu Leu Ala Arg 
625                 630                 635                 640 


Met Tyr Ala Gly Gly Asp Val Ala Leu Lys Lys Arg Lys Arg Ile Thr 
                645                 650                 655     


Ala Lys Asp Leu Gln Arg Tyr Tyr Gly Asn Glu Val Ala Val Gln Lys 
            660                 665                 670         


Ile Leu Gln Lys Gly Leu Cys Ser Thr Arg Glu Glu Gln Gln Arg Val 
        675                 680                 685             


Leu Glu Gln Gln Asn Leu Arg Gly Arg Ile Thr Leu Asn Asp Val Thr 
    690                 695                 700                 


Glu Ile Gln Glu Ile Ile Ser Asp Met Leu Ser Gln Leu Val Thr Phe 
705                 710                 715                 720 


Ser Tyr Phe Arg Glu Arg Asp Gln Met Tyr Leu Leu Leu Gly Phe Tyr 
                725                 730                 735     


Tyr Met Ala Leu Gln Thr Asn Arg Gly Ser Ser Trp Gly Asn Glu Thr 
            740                 745                 750         


Ile Asp Phe Cys Ala Gly Lys Lys Ile Ser Ile Lys Gln Gly Trp Val 
        755                 760                 765             


Leu His Gln Val Arg Ser Val Phe Thr Tyr Gly Leu Lys Leu Tyr Ser 
    770                 775                 780                 


Glu Leu Asp Glu Lys Gly Val Gly Gly Gln Leu Ser Ser Lys Ile Val 
785                 790                 795                 800 


Ala Phe Glu Arg Val His Arg Thr Ser Leu Ala Cys Ala Leu Arg Leu 
                805                 810                 815     


Phe Met Asp Glu Asn Cys Ser Arg Arg Ala Val Asp Val Arg Asn Tyr 
            820                 825                 830         


Val Asp His Phe Lys Tyr Tyr Phe Lys Ala Asp Arg Ser Ile Met Glu 
        835                 840                 845             


Leu Tyr Ser Ala Tyr Tyr Asp Cys Phe Phe Asp Tyr Ser Thr Lys Met 
    850                 855                 860                 


Arg Lys Ser Val Leu Leu Asn Phe Ile Ser Ile Leu Glu Arg His Phe 
865                 870                 875                 880 


Val Val Ser Lys Leu Arg Val Asn Cys Leu Glu Glu Arg Cys Ser Val 
                885                 890                 895     


Ser Phe Ala Glu Ser Leu Lys Ser Glu Lys Phe Thr Tyr Lys Leu Glu 
            900                 905                 910         


Ala Asp Ala Asn Lys Lys Ser Lys Glu Gln Thr Val Glu Phe Pro Ala 
        915                 920                 925             


Arg Asp Lys Glu Phe Leu Glu Ser Leu Gln Ala Glu Leu Glu Tyr Lys 
    930                 935                 940                 


Glu Gly Tyr Asn Ser 
945                 


<210>  900
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  900

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  901
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  901

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  902
<211>  949
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  902

Met Pro His Gln Lys Lys Met Ala Glu Arg Ile Lys Phe Val Asn Tyr 
1               5                   10                  15      


Gly Tyr Tyr Leu Arg Leu Lys Lys Asn Cys Ala Asp Ser Phe Glu Tyr 
            20                  25                  30          


Tyr Trp Cys Asp Tyr Ile Lys Glu Phe Ile Glu Glu Asn Tyr Val Thr 
        35                  40                  45              


Lys Ile Lys Glu Ala Lys Gly Lys Asn Gly Arg Gln Leu Thr Glu Glu 
    50                  55                  60                  


Asn Cys Asn Ser Glu Ala Met Leu Ser Lys Cys Trp His Asp Met Ile 
65                  70                  75                  80  


Arg His Met Cys Ala Lys Tyr Met Asp Leu Gly Lys Ala Val Tyr His 
                85                  90                  95      


Phe Met Leu Pro Gly Lys Ala Glu Gly Asn Asp Leu Cys Leu Asp Arg 
            100                 105                 110         


Leu Asn Asp Ser Phe Ser Lys Gly Ile Thr Ser Phe Asp Tyr Glu Asn 
        115                 120                 125             


Ile Lys Ala Glu Glu Asn Leu Gln Lys Ala Met Phe Gly Val Leu Val 
    130                 135                 140                 


Ser Gly Thr Phe Asn Phe Ser Arg Ser Val Ala Asp Tyr Ser Gly Pro 
145                 150                 155                 160 


Ala Ala Ala Lys Leu Ala Lys Glu Leu Arg Ala Glu Gly Lys Thr Leu 
                165                 170                 175     


Asn Glu Asp Val Leu Met Val Asp Glu Ala His Leu Lys Ala Ile Leu 
            180                 185                 190         


Tyr Ser Asp Ala Lys Arg Lys Leu Leu Arg Tyr Phe Gly Gly Ser Ser 
        195                 200                 205             


Ala Cys Glu Ala Leu Gly Leu Asp Lys Asp Lys Met Val Leu Glu Phe 
    210                 215                 220                 


Arg Gln Ile Phe Arg Gly Leu Arg Asn Ser Ala Phe His Tyr Thr Asp 
225                 230                 235                 240 


Gly Lys Lys Ala Asp Ile Lys Phe Asp Val Thr Arg Gln Leu Trp Ile 
                245                 250                 255     


Gln Asp Val Gln Ala Asn Lys Gln Leu Ile Leu Asp Lys Tyr Tyr Ser 
            260                 265                 270         


Asn Asn Val Cys Arg Tyr Tyr Lys Pro Glu Met Val Lys Lys Leu Ile 
        275                 280                 285             


Gly Asn Leu Tyr His Gly Tyr Val Glu Gln Glu Ala Gln Ile Pro Ala 
    290                 295                 300                 


Phe Arg Thr Val Trp Lys Arg Lys Asp Phe Ala Lys Tyr Leu Asn Asp 
305                 310                 315                 320 


Ser Asn Phe Leu Pro Val Asn Ile Lys Asn Asp Val Lys Glu Arg Thr 
                325                 330                 335     


Val Phe Glu Gly Ala Leu Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg 
            340                 345                 350         


Lys Tyr Thr Val Gly Gln Asp Ala Pro Lys Tyr Phe Phe Glu Ala Val 
        355                 360                 365             


Arg Ala Tyr Ser Asp Glu His Ala Lys Asn Lys Gln Asp Pro Tyr Ala 
    370                 375                 380                 


Asn Gln Ala Lys Asn Phe Trp Asp Tyr Val Glu Lys Leu Gln Lys Ser 
385                 390                 395                 400 


Tyr Glu Lys Gly Thr Leu Thr Phe Gly Ala Val Cys Gln Thr Ile Met 
                405                 410                 415     


Thr Glu Phe Val Gln Gln Asn Ser Lys Ala Thr Glu Lys Glu Gly Glu 
            420                 425                 430         


Ile Tyr Gln His Phe Lys Val Leu Phe Pro Leu Cys Met Gln Arg Gly 
        435                 440                 445             


Phe Glu Lys Tyr Val Lys Glu Lys His Gly Tyr Leu Leu Lys Pro Trp 
    450                 455                 460                 


Leu Asp Thr Val Val Arg Glu Asn Val Leu Gln Asp Ala Ala Ile Thr 
465                 470                 475                 480 


Cys Phe Asp Asp Leu Met Arg Asp Ala Glu Asp Arg Glu Tyr Ser Trp 
                485                 490                 495     


Tyr Val Val Ala His Phe Ile His Pro Lys Lys Leu Asn His Phe Val 
            500                 505                 510         


Gly Ala Leu Lys Asp Tyr Leu Gln Phe Lys Gln Asp Ile Phe Arg Arg 
        515                 520                 525             


Cys Ser Phe Ala Asn Ile Tyr Ser Glu Gly Glu Leu Ser Gln Lys Lys 
    530                 535                 540                 


Ala Met Leu Ala Glu Lys Glu Ala Glu Ile Ser Glu Ile Leu Arg Val 
545                 550                 555                 560 


Met Glu Phe Val Arg Gly Ile Thr Gly Arg Val Ser Lys Thr Phe Ser 
                565                 570                 575     


Asp Tyr Tyr Glu Asn Glu Glu Val Tyr Ala Asn Tyr Leu Gly Lys Tyr 
            580                 585                 590         


Ile Asp Phe Pro Lys Thr Asp Gly Ile Ser Val Phe Glu Ser Phe Arg 
        595                 600                 605             


Asp Phe Cys Thr Asn Thr Leu Pro Asp Gly Asn Val Leu Asp Val Tyr 
    610                 615                 620                 


Met Asp Glu Lys Asn Pro Arg Leu Leu Lys Asn Val Glu Leu Ala Arg 
625                 630                 635                 640 


Met Tyr Ala Gly Gly Asp Val Ala Leu Lys Lys Arg Lys Arg Ile Thr 
                645                 650                 655     


Ala Lys Asp Leu Gln Arg Tyr Tyr Gly Asn Glu Val Ala Val Gln Lys 
            660                 665                 670         


Ile Leu Gln Lys Gly Leu Cys Ser Thr Arg Glu Glu Gln Gln Arg Val 
        675                 680                 685             


Leu Glu Gln Gln Asn Leu Arg Gly Arg Ile Thr Leu Asn Asp Val Thr 
    690                 695                 700                 


Glu Ile Gln Glu Ile Ile Ser Asp Met Leu Ser Gln Leu Val Thr Phe 
705                 710                 715                 720 


Ser Tyr Phe Arg Glu Arg Asp Gln Met Tyr Leu Leu Leu Gly Phe Tyr 
                725                 730                 735     


Tyr Met Ala Leu Gln Thr Asn Arg Gly Ser Ser Trp Gly Asn Glu Thr 
            740                 745                 750         


Ile Asp Phe Cys Ala Gly Lys Lys Ile Ser Ile Lys Gln Gly Trp Val 
        755                 760                 765             


Leu His Gln Val Arg Ser Val Phe Thr Tyr Gly Leu Lys Leu Tyr Ser 
    770                 775                 780                 


Glu Leu Asp Glu Lys Gly Val Gly Gly Gln Leu Ser Ser Lys Ile Val 
785                 790                 795                 800 


Ala Phe Glu Arg Val His Arg Thr Ser Leu Ala Cys Ala Leu Arg Leu 
                805                 810                 815     


Phe Met Asp Glu Asn Cys Ser Arg Arg Ala Val Asp Val Arg Asn Tyr 
            820                 825                 830         


Val Asp His Phe Lys Tyr Tyr Phe Lys Ala Asp Arg Ser Ile Met Glu 
        835                 840                 845             


Leu Tyr Ser Ala Tyr Tyr Asp Cys Phe Phe Asp Tyr Ser Thr Lys Met 
    850                 855                 860                 


Arg Lys Ser Val Leu Leu Asn Phe Ile Ser Ile Leu Glu Arg His Phe 
865                 870                 875                 880 


Val Val Ser Lys Leu Arg Val Asn Cys Leu Glu Glu Arg Cys Ser Val 
                885                 890                 895     


Ser Phe Ala Glu Ser Leu Lys Ser Glu Lys Phe Thr Tyr Lys Leu Glu 
            900                 905                 910         


Ala Asp Ala Asn Lys Lys Ser Lys Glu Gln Thr Val Glu Phe Pro Ala 
        915                 920                 925             


Arg Asp Lys Glu Phe Leu Glu Ser Leu Gln Ala Glu Leu Glu Tyr Lys 
    930                 935                 940                 


Glu Gly Tyr Asn Ser 
945                 


<210>  903
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  903

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Tyr Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Glu 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Ala Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Ser Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Lys Ile Leu Lys Tyr Thr Glu Ser Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Lys Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Leu Lys Glu Leu Lys Glu Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn Tyr Thr Met Gln Gln Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Lys Lys Asp Glu Lys Phe Asn Asp Glu Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asn Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Lys Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Glu Lys Leu Thr Thr  Asn Arg Asn Ser Lys  Glu Leu Cys 
    1130                 1135                 1140             


Lys Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Glu  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  904
<211>  949
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  904

Met Pro His Gln Lys Lys Met Ala Glu Arg Ile Lys Phe Val Asn Tyr 
1               5                   10                  15      


Gly Tyr Tyr Leu Arg Leu Lys Lys Asn Cys Ala Asp Ser Phe Glu Tyr 
            20                  25                  30          


Tyr Trp Cys Asp Tyr Ile Lys Glu Phe Ile Glu Glu Asn Tyr Val Thr 
        35                  40                  45              


Lys Ile Lys Glu Ala Lys Gly Lys Asn Gly Arg Gln Leu Thr Glu Glu 
    50                  55                  60                  


Asn Cys Asn Ser Glu Ala Met Leu Ser Lys Cys Trp His Asp Met Ile 
65                  70                  75                  80  


Arg His Met Cys Ala Lys Tyr Met Asp Leu Gly Lys Ala Val Tyr His 
                85                  90                  95      


Phe Met Leu Pro Gly Lys Ala Glu Gly Asn Asp Leu Cys Leu Asp Arg 
            100                 105                 110         


Leu Asn Asp Ser Phe Ser Lys Gly Ile Thr Ser Phe Asp Tyr Glu Asn 
        115                 120                 125             


Ile Lys Ala Glu Glu Asn Leu Gln Lys Ala Met Phe Gly Val Leu Val 
    130                 135                 140                 


Ser Gly Thr Phe Asn Phe Ser Arg Ser Val Ala Asp Tyr Ser Gly Pro 
145                 150                 155                 160 


Ala Ala Ala Lys Leu Ala Lys Glu Leu Arg Ala Glu Gly Lys Thr Leu 
                165                 170                 175     


Asn Glu Asp Val Leu Met Val Asp Glu Ala His Leu Lys Ala Ile Leu 
            180                 185                 190         


Tyr Ser Asp Ala Lys Arg Lys Leu Leu Arg Tyr Phe Gly Gly Ser Ser 
        195                 200                 205             


Ala Cys Glu Ala Leu Gly Leu Asp Lys Asp Lys Met Val Leu Glu Phe 
    210                 215                 220                 


Arg Gln Ile Phe Arg Gly Leu Arg Asn Ser Ala Phe His Tyr Thr Asp 
225                 230                 235                 240 


Gly Lys Lys Ala Asp Ile Lys Phe Asp Val Thr Arg Gln Leu Trp Ile 
                245                 250                 255     


Gln Asp Val Gln Ala Asn Lys Gln Leu Ile Leu Asp Lys Tyr Tyr Ser 
            260                 265                 270         


Asn Asn Val Cys Arg Tyr Tyr Lys Pro Glu Met Val Lys Lys Leu Ile 
        275                 280                 285             


Gly Asn Leu Tyr His Gly Tyr Val Glu Gln Glu Ala Gln Ile Pro Ala 
    290                 295                 300                 


Phe Arg Thr Val Trp Lys Arg Lys Asp Phe Ala Lys Tyr Leu Asn Asp 
305                 310                 315                 320 


Ser Asn Phe Leu Pro Val Asn Ile Lys Asn Asp Val Lys Glu Arg Thr 
                325                 330                 335     


Val Phe Glu Gly Ala Leu Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg 
            340                 345                 350         


Lys Tyr Thr Val Gly Gln Asp Ala Pro Lys Tyr Phe Phe Glu Ala Val 
        355                 360                 365             


Arg Ala Tyr Ser Asp Glu His Ala Lys Asn Lys Gln Asp Pro Tyr Ala 
    370                 375                 380                 


Asn Gln Ala Lys Asn Phe Trp Asp Tyr Val Glu Lys Leu Gln Lys Ser 
385                 390                 395                 400 


Tyr Glu Lys Gly Thr Leu Thr Phe Gly Ala Val Cys Gln Thr Ile Met 
                405                 410                 415     


Thr Glu Phe Val Gln Gln Asn Ser Lys Ala Thr Glu Lys Glu Gly Glu 
            420                 425                 430         


Ile Tyr Gln His Phe Lys Val Leu Phe Pro Leu Cys Met Gln Arg Gly 
        435                 440                 445             


Phe Glu Lys Tyr Val Lys Glu Lys His Gly Tyr Leu Leu Lys Pro Trp 
    450                 455                 460                 


Leu Asp Thr Val Val Arg Glu Asn Val Leu Gln Asp Ala Ala Ile Thr 
465                 470                 475                 480 


Cys Phe Asp Asp Leu Met Arg Asp Ala Glu Asp Arg Glu Tyr Ser Trp 
                485                 490                 495     


Tyr Val Val Ala His Phe Ile His Pro Lys Lys Leu Asn His Phe Val 
            500                 505                 510         


Gly Ala Leu Lys Asp Tyr Leu Gln Phe Lys Gln Asp Ile Phe Arg Arg 
        515                 520                 525             


Cys Ser Phe Ala Asn Ile Tyr Ser Glu Gly Glu Leu Ser Gln Lys Lys 
    530                 535                 540                 


Ala Met Leu Ala Glu Lys Glu Ala Glu Ile Ser Glu Ile Leu Arg Val 
545                 550                 555                 560 


Met Glu Phe Val Arg Gly Ile Thr Gly Arg Val Ser Lys Thr Phe Ser 
                565                 570                 575     


Asp Tyr Tyr Glu Asn Glu Glu Val Tyr Ala Asn Tyr Leu Gly Lys Tyr 
            580                 585                 590         


Ile Asp Phe Pro Lys Thr Asp Gly Ile Ser Val Phe Glu Ser Phe Arg 
        595                 600                 605             


Asp Phe Cys Thr Asn Thr Leu Pro Asp Gly Asn Val Leu Asp Val Tyr 
    610                 615                 620                 


Met Asp Glu Lys Asn Pro Arg Leu Leu Lys Asn Val Glu Leu Ala Arg 
625                 630                 635                 640 


Met Tyr Ala Gly Gly Asp Val Ala Leu Lys Lys Arg Lys Arg Ile Thr 
                645                 650                 655     


Ala Lys Asp Leu Gln Arg Tyr Tyr Gly Asn Glu Val Ala Val Gln Lys 
            660                 665                 670         


Ile Leu Gln Lys Gly Leu Cys Ser Thr Arg Glu Glu Gln Gln Arg Val 
        675                 680                 685             


Leu Glu Gln Gln Asn Leu Arg Gly Arg Ile Thr Leu Asn Asp Val Thr 
    690                 695                 700                 


Glu Ile Gln Glu Ile Ile Ser Asp Met Leu Ser Gln Leu Val Thr Phe 
705                 710                 715                 720 


Ser Tyr Phe Arg Glu Arg Asp Gln Met Tyr Leu Leu Leu Gly Phe Tyr 
                725                 730                 735     


Tyr Met Ala Leu Gln Thr Asn Arg Gly Ser Ser Trp Gly Asn Glu Thr 
            740                 745                 750         


Ile Asp Phe Cys Ala Gly Lys Lys Ile Ser Ile Lys Gln Gly Trp Val 
        755                 760                 765             


Leu His Gln Val Arg Ser Val Phe Thr Tyr Gly Leu Lys Leu Tyr Ser 
    770                 775                 780                 


Glu Leu Asp Glu Lys Gly Val Gly Gly Gln Leu Ser Ser Lys Ile Val 
785                 790                 795                 800 


Ala Phe Glu Arg Val His Arg Thr Ser Leu Ala Cys Ala Leu Arg Leu 
                805                 810                 815     


Phe Met Asp Glu Asn Cys Ser Arg Arg Ala Val Asp Val Arg Asn Tyr 
            820                 825                 830         


Val Asp His Phe Lys Tyr Tyr Phe Lys Ala Asp Arg Ser Ile Met Glu 
        835                 840                 845             


Leu Tyr Ser Ala Tyr Tyr Asp Cys Phe Phe Asp Tyr Ser Thr Lys Met 
    850                 855                 860                 


Arg Lys Ser Val Leu Leu Asn Phe Ile Ser Ile Leu Glu Arg His Phe 
865                 870                 875                 880 


Val Val Ser Lys Leu Arg Val Asn Cys Leu Glu Glu Arg Cys Ser Val 
                885                 890                 895     


Ser Phe Ala Glu Ser Leu Lys Ser Glu Lys Phe Thr Tyr Lys Leu Glu 
            900                 905                 910         


Ala Asp Ala Asn Lys Lys Ser Lys Glu Gln Thr Val Glu Phe Pro Ala 
        915                 920                 925             


Arg Asp Lys Glu Phe Leu Glu Ser Leu Gln Ala Glu Leu Glu Tyr Lys 
    930                 935                 940                 


Glu Gly Tyr Asn Ser 
945                 


<210>  905
<211>  1380
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  905

Met Lys Leu Ser Lys Glu Lys Gln Ile Arg Ser Ala Val Ala Asn Lys 
1               5                   10                  15      


Glu Lys Asn Thr Glu Gly Val Leu Tyr Arg Phe Pro Gly Asp Asp Ile 
            20                  25                  30          


Gly Gly Val Gln Ala Gln Met Leu Val Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Leu Gly Asn Lys Pro Lys Glu 
    50                  55                  60                  


Trp Met Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Lys Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Ala Ile Asn Asp Ile Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Lys Glu Ala Asp Lys Lys Ile Arg Asn Met Ser Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Asn Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Ser Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Gly Asn Gln Glu Phe Asp Ser Ile Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Asp Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Ser Ile Gln Asp Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Ile Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Glu Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Asp Gly Leu Asn Glu Phe Met Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Glu Glu Lys Arg Ala Glu Val Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Ser His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Val Asn Lys Gly Lys Phe Tyr Val Trp 
305                 310                 315                 320 


Lys Lys His Glu Cys Gly Lys Lys Glu Asn Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Val Glu Ala Glu Ala Glu Ser Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Ile Phe Phe Glu Asn Asp Thr Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Thr Gly Thr Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Lys Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asn Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Gln Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Leu 
            660                 665                 670         


Val Arg Thr Val Phe Pro Glu Tyr Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Asn Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Arg Thr Leu Arg Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Lys 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Glu Asn Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Cys Ala Gln Asp 
            900                 905                 910         


Ile Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu 
        915                 920                 925             


Leu Ser Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Lys Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Lys Phe Ser Glu Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Thr Asn Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Gly  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Glu Lys Pro Glu  Glu Tyr Glu Lys Ile  Glu Ala Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Ile  Tyr Ala Pro Glu Lys  Asn Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Gln Gly Arg Val Gly  Ala Lys Val 
    1145                 1150                 1155             


Thr Ser  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Glu Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Met Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Val Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Val Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Glu Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asn Ala 
    1280                 1285                 1290             


Lys Asp  Lys Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Asp  Ala Glu Asp Ala Asp  Ser Lys Lys Pro Val  Ile Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Glu  Asp Glu Asp 
    1325                 1330                 1335             


Lys Gln  Lys Gly Lys Glu Asn  Arg Gly Lys Lys Asn  Thr Glu Thr 
    1340                 1345                 1350             


Arg Ser  Asp Ala Glu Lys Asn  Asn Asn Glu Arg Leu  Ser Tyr Asn 
    1355                 1360                 1365             


Pro Phe  Ala Asn Phe Asp Phe  Lys Leu Pro Asn Lys  
    1370                 1375                 1380 


<210>  906
<211>  1245
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  906

Met Lys Ile Ser Lys Val Asn His Val Lys Thr Gly Val Ser Ala Lys 
1               5                   10                  15      


Pro Ala Ile Glu Gly Gly Met Leu Tyr Asp Tyr Pro Ser Lys Glu Gly 
            20                  25                  30          


Gly Ser Lys Asp Leu Arg Lys His Ile Glu Glu Val Asn Arg Lys Ala 
        35                  40                  45              


Gln Ile Leu Tyr Asn Val Phe Asn Gln Val Lys Glu Lys Asp Lys Lys 
    50                  55                  60                  


Gln Asn Ser Val Lys Asp Ala Leu Lys Ile Ala Asn Ala Tyr Ile Asn 
65                  70                  75                  80  


Ser Thr Val Ile Phe Gly Ile Lys Lys Glu Phe Pro Glu Asn Lys Ile 
                85                  90                  95      


Cys Asn Asn Phe Ser Tyr Ala Val Asn Arg Pro Ile Arg Leu Gly Lys 
            100                 105                 110         


Glu Asn Val Phe Ile Thr Ser Ile Ser Val Ser Val Lys Glu Lys Ser 
        115                 120                 125             


Ala Lys Glu Ser Ala Glu Tyr Ile Val Asn Asn Tyr Leu Arg Asn Ser 
    130                 135                 140                 


Leu Arg Arg Asp Lys Arg Ala Ala Glu Thr Ile Val Arg Ile Leu Thr 
145                 150                 155                 160 


Ala Leu Tyr Asp Gly Lys Asn Tyr Glu Lys Leu Ile Lys Lys Ile Glu 
                165                 170                 175     


Arg Glu Asp Leu Ala Ala Val Val Ser Ala Val Ser Arg Asp Tyr Leu 
            180                 185                 190         


Lys Asp Gly Glu Leu Glu Lys Ile Ala Val Ser Ile Glu Lys Gln Lys 
        195                 200                 205             


Val Leu Val Gln Val Gly Lys Asp Gly Tyr Leu Ile Pro Ser Gly Ala 
    210                 215                 220                 


Glu His Glu Lys Lys Ala Tyr Ile Phe Asn Phe Met Lys Lys Tyr Ala 
225                 230                 235                 240 


Glu Ser Asp Glu Glu Gly Gln Arg Lys Met Leu Asn His Met Lys Asp 
                245                 250                 255     


Leu Ile Arg Leu Tyr Tyr Thr Glu Glu Glu Val Val Ser Ser Glu Ile 
            260                 265                 270         


Leu Asp Leu Ile Asn Ser Arg Asp Asn Thr Pro Phe Ser Gln Lys Asp 
        275                 280                 285             


Ile Ile Arg Ser Tyr Asn Glu Gln Ile Ala Glu Lys Val Ser Ala Phe 
    290                 295                 300                 


Leu Val Glu Arg Tyr Gln Lys Thr Leu Lys Asp Ala Lys Ser Glu Asp 
305                 310                 315                 320 


Glu Glu Gly Trp Val Arg Tyr Ile Ser Asp Lys Ala Glu Lys Leu Leu 
                325                 330                 335     


Ser Val Lys Asn Leu Thr Gln Asp Arg Ile His Cys Asp Tyr Leu Phe 
            340                 345                 350         


Lys Lys Thr Trp Glu Glu Trp Thr Ser Phe Ile Ala Lys Lys Tyr Ile 
        355                 360                 365             


Asp Leu Gly Lys Ala Thr Tyr Asn Phe Ala Met Gly Asp Ile Ser Lys 
    370                 375                 380                 


Val Ser Lys Gly Glu Ser Val Ala Phe Gly Thr Val Asn Glu Gly Phe 
385                 390                 395                 400 


Glu Thr Gly Ile Ser Ser Phe Asp Tyr Glu Arg Met Lys Ala Glu Asp 
                405                 410                 415     


Ser Leu Asn Arg Ala Met Ile Lys Tyr Ile Ser Phe Ala Val Asn Ile 
            420                 425                 430         


Phe Asp Ala Ser Val Arg Asn Pro Glu Gln Arg Thr Gly Gly Lys Glu 
        435                 440                 445             


Asp Ile Leu Leu Leu Lys Pro Glu Asn Ile Val Met Tyr Glu Asp Ala 
    450                 455                 460                 


Val Lys Arg Val Leu Arg Tyr Phe Gly Gly Ile Ser Lys Phe Ser Glu 
465                 470                 475                 480 


Ser Ser Leu Asp Val Ser Asp Lys Asn Gly Phe Phe Thr Ala Leu Lys 
                485                 490                 495     


Asp Glu Leu Tyr Ala Ala Arg Asn Tyr Ala Phe His Tyr Val Thr Gly 
            500                 505                 510         


Glu Ala Glu Lys Arg Glu Lys Pro Val Val Thr Thr Leu Leu Asp Thr 
        515                 520                 525             


Glu Tyr Met Leu Val Gly Ser Ile Phe Arg Lys Lys Tyr Phe Ser Asn 
    530                 535                 540                 


Asn Val Pro Met Phe Tyr Arg Thr Ala Asp Ile Asp Asn Leu Met Ser 
545                 550                 555                 560 


Arg Leu Tyr Lys Ser Asn Arg Val Ile Leu Ala Gln Met Pro Ser Phe 
                565                 570                 575     


Asn Lys Val Leu Ser Arg Asn Ala Val Val Asp Phe Ala Asn Ala Tyr 
            580                 585                 590         


Leu Ala Gly Asp Ser Lys Arg Glu Met Ser Gln Pro Glu Ile Ser Glu 
        595                 600                 605             


Gln Phe Arg Ser Ser Phe Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Tyr 
    610                 615                 620                 


Asp Phe Ile Leu Lys Glu Asp Leu Leu Glu Arg Phe Lys Asn Gly Val 
625                 630                 635                 640 


Glu Cys Ala Gln Ala Ser Ala Ile Lys Lys Glu Asn Asn Ser Arg Lys 
                645                 650                 655     


His Val Ala Met Lys Asn Ala Tyr Arg Asp Phe Met Ser Arg Ala Asp 
            660                 665                 670         


Lys Leu Thr Lys Thr Lys Gly Ile Thr Phe Gly Gln Phe Cys Gln Glu 
        675                 680                 685             


Ile Met Thr Glu Tyr Asn Gln Gln Asn Ser Gln Lys Gln Lys Lys Pro 
    690                 695                 700                 


Ser Ala Val Glu Lys Thr Tyr Val Val Lys Gly Gln Thr Arg Thr Ser 
705                 710                 715                 720 


Val Arg Glu Val Glu Asp Lys Glu Gln Ile Tyr Lys His Tyr Arg Thr 
                725                 730                 735     


Leu Leu Tyr Ala Gly Ile Arg Glu Ala Phe Leu Ile Tyr Leu Lys Glu 
            740                 745                 750         


Glu Ala Ala Phe Gly Phe Leu Arg Ser Pro Lys Asp Gly Arg Glu Lys 
        755                 760                 765             


Phe Arg Asp Leu Lys Glu Glu Asp Phe Ser Gln Gly Trp Thr Thr Glu 
    770                 775                 780                 


Cys Tyr Thr Lys Leu Lys Asp Ala Ile Ile Glu Asp Lys Glu Leu Ser 
785                 790                 795                 800 


Ser Trp Tyr Val Thr Ala His Phe Met Asn Gln Lys His Leu Asn His 
                805                 810                 815     


Leu Ile Gly Glu Ile Lys Asn Tyr Val Gln Phe Ile Asp Asp Ile Glu 
            820                 825                 830         


Lys Arg Ala Lys Val Thr Gly Asn Arg Val Cys Ser Thr Glu Glu Lys 
        835                 840                 845             


Met Gly Lys Phe Thr Ser Leu Leu Glu Val Leu Glu Phe Cys Lys Leu 
    850                 855                 860                 


Phe Cys Gly Gln Val Ser Asn Asn Leu Glu Asp Tyr Phe Ala Asn Asn 
865                 870                 875                 880 


Glu Glu Tyr Ala Lys Tyr Val Ala Gly Phe Val Asp Tyr Gly Gly Thr 
                885                 890                 895     


Ser Ala Ala Leu Leu Gln Ala Phe Cys Arg Glu Asn Lys Glu Leu Asn 
            900                 905                 910         


Tyr Tyr Asp Glu Leu Asn Pro Ile Pro Asn Arg Asn Ile Ile Leu Ser 
        915                 920                 925             


Leu Leu Tyr Gly Asn Thr Ala Val Leu Ser Ser Ser Met Lys Lys Val 
    930                 935                 940                 


Thr Leu Gln Glu Val Lys Gly Tyr Gln Lys Asn Lys Glu Ser Leu Ser 
945                 950                 955                 960 


Gly Val Phe Lys Asn Gly Ala Cys Lys Asp Glu Asn Glu Gln Arg Lys 
                965                 970                 975     


Met Ser Asn Tyr Gln Lys Gln Lys Asn Arg Ile Glu Phe Val Asp Val 
            980                 985                 990         


Leu Thr Leu Thr Glu Leu Leu Asn  Asp Leu Tyr Gly Gln  Leu Ile Ser 
        995                 1000                 1005             


Tyr Ser  Tyr Leu Arg Glu Arg  Asp Leu Met Phe Met  Gln Leu Gly 
    1010                 1015                 1020             


Phe Tyr  Tyr Thr Lys Leu Phe  His Thr Ser Ser Val  Pro Ala Gln 
    1025                 1030                 1035             


Asp Lys  Leu Arg Val Leu Ser  Gly Asp Cys Asp Ile  Lys Asp Gly 
    1040                 1045                 1050             


Ala Val  Leu Tyr Gln Ile Ala  Ala Met Tyr Ser Tyr  Asp Leu Pro 
    1055                 1060                 1065             


Ile Tyr  Gly Ile Ser Lys Gln  Gly Val Ala Val Arg  Lys Lys Ser 
    1070                 1075                 1080             


Gly Val  Ser Thr Gly Ala Lys  Leu Asn Gln Phe Ser  Thr Glu Tyr 
    1085                 1090                 1095             


Cys Gly  Gly Lys Trp Asp Ile  Tyr Thr Asn Gly Leu  Tyr Phe Phe 
    1100                 1105                 1110             


Glu Asp  Val Asp Gly Arg His  Lys Asp Tyr Val Glu  Val Arg Asn 
    1115                 1120                 1125             


Tyr Ile  Glu His Phe Lys Tyr  Phe Ala Asp His Lys  Lys Ser Ile 
    1130                 1135                 1140             


Leu Asp  Leu Tyr Ser Asp Leu  Tyr Asn Gly Phe Phe  Ser Tyr Asp 
    1145                 1150                 1155             


Thr Lys  Leu Lys Lys Ser Met  Ser Phe Val Leu Pro  Asn Ile Leu 
    1160                 1165                 1170             


Leu Ser  His Phe Val Asn Ala  Lys Leu Ser Tyr Glu  Lys Asp Val 
    1175                 1180                 1185             


Val Gln  Lys Asn Ser Glu Ser  Tyr Arg Arg Ala Arg  Ile Val Ile 
    1190                 1195                 1200             


Arg Glu  Lys Asp Ile Lys Ser  Asp Phe Leu Thr Tyr  Lys Asn Lys 
    1205                 1210                 1215             


Glu Asn  Ser Lys Ala Phe Tyr  Val Pro Ala Arg Asn  Asp Val Phe 
    1220                 1225                 1230             


Leu Lys  Glu Val Leu Asp Met  Ile Ser Phe Lys Arg  
    1235                 1240                 1245 


<210>  907
<211>  1373
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  907

Met Ala Lys His Leu Arg Pro Ile Gly Glu Ser Tyr Thr Asp Phe Leu 
1               5                   10                  15      


Asp Glu Thr Glu Phe Val Arg Leu Gly Arg Gly Leu His Arg Gly His 
            20                  25                  30          


His Gly Val Gln Ile Pro Pro Thr Glu Leu Pro Ser Tyr Leu Ala Glu 
        35                  40                  45              


Tyr Arg Lys Ala Leu Met Arg Gln Val Val Ala Val Leu Asp Lys Val 
    50                  55                  60                  


Val Gly Lys Arg Arg Arg Leu Ser Gly Met His Pro Glu Ala Tyr Arg 
65                  70                  75                  80  


Asp Arg Val His Leu Ala Glu Ala Leu Trp Val Arg Leu Val Ala Arg 
                85                  90                  95      


Val Lys Glu Ile Gly Thr Pro Pro Asp Pro Ser Glu Leu Leu Asp Leu 
            100                 105                 110         


Arg Arg Met Trp Asn Ala Lys Ala His Pro Tyr Ala Glu Tyr Asp Val 
        115                 120                 125             


Val Pro Arg Ala Pro Leu Asn Asp Gly Asn Gly Gln Lys Ile Leu Glu 
    130                 135                 140                 


Cys Arg Glu Val Asp Asp Pro Lys Ile Glu Arg Ser Asp Phe Glu Gly 
145                 150                 155                 160 


Arg Trp His Gly Arg Phe Trp Gln Ser Glu Pro Gly Pro Val Asp Tyr 
                165                 170                 175     


Asn Ala Ile Ala Asp Arg Ile Phe Ala His Leu Phe Asp Gln Glu Ala 
            180                 185                 190         


Val Ile Gly Gly Gly Pro Arg Arg Glu Gly Asn Val Thr Val Pro Asp 
        195                 200                 205             


Glu Asp Ile Asn Gly Gln Pro Gly Pro Ala Thr Gly Lys Gly Leu Ile 
    210                 215                 220                 


Ile Ala Arg Gly Gln Ser Ile Val Lys Ser Ala Ser Asp Pro Arg Arg 
225                 230                 235                 240 


Ser Ser Lys Lys Val Gln Arg Thr Trp Asp Lys Ala Val Glu Arg Arg 
                245                 250                 255     


Tyr Phe Gly Asp Asp Gly Lys Gly Gly Ser Asp Ile Ala Lys Ala Ile 
            260                 265                 270         


Tyr Glu Glu Leu Gly Asp Pro Ala Thr Leu Ala Asp Pro Ile Tyr Ala 
        275                 280                 285             


Ser Trp Phe Gly Ser Arg Leu Tyr Asp His Phe Gly Ser Phe Lys Asn 
    290                 295                 300                 


Ser Leu Pro Leu Glu Leu Lys Asp Pro Phe Lys Glu Gln Ile Trp Ala 
305                 310                 315                 320 


Leu His Asn Ser Val Arg Gln Phe Tyr Gln Arg Met Ala Lys Ser Asp 
                325                 330                 335     


Arg Phe Arg Leu Ala Leu Gln Asn Ala Arg Ser Glu Val Pro Asp Arg 
            340                 345                 350         


Ser Glu Leu Leu Ala Leu Leu Pro Lys Asp His Asp His Leu Leu Leu 
        355                 360                 365             


Val Leu Gly Gly Lys Lys Lys Asn Ala Glu Met Ser Glu Leu Ile Arg 
    370                 375                 380                 


Leu Gly Lys Leu Phe Val His Ala Ser Asp Val Leu His Asp Phe Asp 
385                 390                 395                 400 


Ala Asn Asp Ala Ala Ala Leu Asp Ala Phe Lys Arg Arg Met Ser Phe 
                405                 410                 415     


Leu Ala Thr Ser Ile Gly Gln Ser Glu Ile Lys Gln Thr Glu Thr Phe 
            420                 425                 430         


Ala Arg Thr Trp Arg Gly Ala Val Gly Leu Thr Leu Arg Thr Val Lys 
        435                 440                 445             


Gly Leu Ala Asp Pro Arg Gly Ile Ile Gly Thr Pro Asp Asn Arg Asp 
    450                 455                 460                 


Leu Gly Thr Ala Gly Pro Met Lys Asp Ala Phe Asn Lys Phe Asp Gln 
465                 470                 475                 480 


Pro His Phe Gln Gln His Met Thr Ile Ile Phe Gly Asn Lys Glu Leu 
                485                 490                 495     


Gln Ala Glu Gly Asn Pro Thr Arg Ser Ser Val Phe Thr Ala Asn Gly 
            500                 505                 510         


Asp Lys Asp His Gln Ala Glu Leu Leu Trp Gly Phe Leu Cys Val Val 
        515                 520                 525             


Arg Ser Val Arg Asn Arg Thr Asn His Tyr Asn Val Arg Arg Ala Leu 
    530                 535                 540                 


Leu Arg Leu Leu Asp Glu Gly Ile Val Ser Pro Met Pro Ser Asp Pro 
545                 550                 555                 560 


Lys Lys Glu Arg Val Glu Asn Arg Asn Leu Cys Thr Val Ser Pro Thr 
                565                 570                 575     


Ala Leu Glu Ala Phe Arg Arg Leu Leu Asn Phe Asp Leu Ala Ile Gln 
            580                 585                 590         


Lys Glu Ala Val Arg Thr Ala Leu Glu Gln Ala Lys Ala Ser Glu Phe 
        595                 600                 605             


Val Glu Glu Gly Lys Leu Arg Gly Leu Val Ser Glu Leu Ala Gly Thr 
    610                 615                 620                 


Glu Asp Met Pro Ala Leu His Ile Pro Arg Phe Ser Ala Val Met Asp 
625                 630                 635                 640 


Lys Val Arg Arg Leu Ala Asp Asn Arg Asp Val Gly Leu Asp Pro Ile 
                645                 650                 655     


Leu Ser Thr Leu Gln Arg Ser Leu Pro Pro Thr Asp Lys Gln Ala Glu 
            660                 665                 670         


Ser Asp Ala Ala Arg Cys Arg Tyr Arg Leu Leu Leu Glu Leu Tyr Lys 
        675                 680                 685             


Ser Gly Phe Arg Ser Trp Phe Ser Gly Ile Gln Ser Asn Glu Glu Asn 
    690                 695                 700                 


Asn Arg Glu Ile Cys His Trp Ala Val Lys Gln Val Gly Arg Ala Lys 
705                 710                 715                 720 


Asp Ala Arg Lys Ser Glu Tyr Asp Lys Lys Thr Lys Arg His Tyr Arg 
                725                 730                 735     


Ser Pro Asn Ser Leu Ile Asp Asp Leu Gly Leu Asp Lys Phe Asp Asp 
            740                 745                 750         


Leu Thr Asp Leu Leu Glu Ala Leu Ala Ser Gln Ser Thr Arg Glu His 
        755                 760                 765             


Asp Gln Asn Leu Lys Tyr Val Pro Asp Ala Arg Val Gln Ser Gln Met 
    770                 775                 780                 


Ser Asn Arg Ile Glu Glu Phe Arg Gln Glu Leu Phe Ala His Ile Phe 
785                 790                 795                 800 


Thr Lys Tyr Leu Asp Thr His Asp Phe Gly Trp Ile Gly Ala Ile Glu 
                805                 810                 815     


Val Arg Arg Glu Ala Cys Asp Leu Ala Asp Val Val Ser Ala Phe Glu 
            820                 825                 830         


Val Arg Asp Gln Lys Phe Asp Ala Asp Trp His Ser Gln Phe Tyr Ala 
        835                 840                 845             


Trp Leu Tyr Met Val Pro Pro Ile Glu Ala Ser Arg Leu Arg His Gln 
    850                 855                 860                 


Met Arg Lys Ser Ala Val Met Asp Asp Lys Trp Ser Thr Thr Leu Glu 
865                 870                 875                 880 


Leu Thr Ser Gly Asp Arg Lys Thr Arg Asp Asp His Ala Gln Asp Val 
                885                 890                 895     


Leu Ala Asp Met Asp Arg Leu Phe Ser Leu Tyr Thr Lys Val Gln Ala 
            900                 905                 910         


Ala Gly Phe Asn Gly Gln Glu His Glu Ser Ala Leu Gly Ser Lys Ser 
        915                 920                 925             


Leu Phe Tyr Glu Asp Gly Asn Gln Phe Asp Glu Val Tyr Ser Pro Asp 
    930                 935                 940                 


Thr Glu Thr His Asn Lys Thr Phe Pro Gly Thr Arg Arg Gly Leu Arg 
945                 950                 955                 960 


Gln Leu Val Arg Tyr Ala His Leu Pro Ala Leu Glu Gly Val Phe Lys 
                965                 970                 975     


Lys His Arg Ile Thr Lys Ala Glu Val Glu Thr Phe Val Ala Leu Tyr 
            980                 985                 990         


Asp Glu Asn Arg Arg Asp Pro Gly  Ser Val Ala His Met  Leu Arg Arg 
        995                 1000                 1005             


Glu Lys  Leu Arg Thr Glu Ile  Leu Arg Ser Ile His  Asp Gly Pro 
    1010                 1015                 1020             


Lys Pro  Lys Asp Lys Asp Phe  Trp Pro Lys Leu Glu  Ala Lys Cys 
    1025                 1030                 1035             


Leu Glu  Tyr Arg Thr Val Ala  Thr Glu Thr Ala Ile  Tyr Asn Phe 
    1040                 1045                 1050             


Gln Ala  Asn Ala Ala Arg Leu  Asn Asp His Ala Arg  Leu His Gln 
    1055                 1060                 1065             


Ile Val  Met Arg Val Val Ala  Arg Leu Thr Asp Tyr  Ala Leu Ile 
    1070                 1075                 1080             


Trp Glu  Arg Asp Arg Leu Phe  Ala Phe Val Gly Met  Leu Tyr Arg 
    1085                 1090                 1095             


Gln Thr  Gly Gly Thr Gly Ile  Asn Pro Ala Met Arg  His Ala Glu 
    1100                 1105                 1110             


Lys Thr  Asn Ala Pro Pro Arg  Ile Gly Ile Leu Val  Ser Asp Ser 
    1115                 1120                 1125             


Ala Leu  Ala Lys Lys Leu Asn  Ser Asn Ser Ala Glu  Val Phe Ile 
    1130                 1135                 1140             


Pro Tyr  Leu Asp Thr Glu Thr  Gly Phe Asp Ala Pro  Arg Phe Asp 
    1145                 1150                 1155             


Asp Leu  Cys Thr Leu Leu Ser  His Glu His Ala Lys  Glu Phe Arg 
    1160                 1165                 1170             


Phe His  Phe Leu Glu Val Gly  Glu Glu Asn Ser Lys  Asp Glu Ala 
    1175                 1180                 1185             


Arg Arg  Leu Asn Glu Glu Thr  Met Gly His Arg Lys  Arg Pro Ala 
    1190                 1195                 1200             


Phe Lys  Arg Gly Thr Arg Arg  Gln Gly Ile Arg Asn  Asp Leu Ala 
    1205                 1210                 1215             


His His  Asn Val Leu Asp Leu  Ala Gly Gly Ala Gly  Pro Asn Leu 
    1220                 1225                 1230             


Thr Tyr  Val Val Asn Ala Val  Arg Ser Leu Leu Ser  Tyr Asp Arg 
    1235                 1240                 1245             


Lys Leu  Lys Asn Ala Val Pro  Lys Ser Ile Lys Arg  Ile Leu Gly 
    1250                 1255                 1260             


Glu Glu  Gly Leu Ile Ile Glu  Trp Gln Met Asn Tyr  Asp Arg Leu 
    1265                 1270                 1275             


Lys Lys  Pro Thr Val Tyr Pro  Asn Val Glu Thr His  Leu Thr Met 
    1280                 1285                 1290             


Val Pro  Pro Arg His Met Thr  Ala Pro Val Ser Phe  Thr Leu Pro 
    1295                 1300                 1305             


Arg Ala  Ser Val Arg Leu Ala  Ser Met Val Lys Ala  Val Phe Asp 
    1310                 1315                 1320             


Phe Gly  Ser Ser Gly Tyr Gly  Glu Glu Arg Met Ile  Gly Gly Arg 
    1325                 1330                 1335             


Thr Ala  Lys Gln Ala Val Tyr  Pro Asp Asp Phe Thr  Arg Arg Phe 
    1340                 1345                 1350             


Pro Gln  Thr Pro Met Gly Leu  Lys Gln Ala Thr Arg  Leu Val Phe 
    1355                 1360                 1365             


Ala Ser  Glu Asn Ser 
    1370             


<210>  908
<211>  1373
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  908

Met Ala Lys His Leu Arg Pro Ile Gly Glu Ser Tyr Thr Asp Phe Leu 
1               5                   10                  15      


Asp Glu Thr Glu Phe Val Arg Leu Gly Arg Gly Leu His Arg Gly His 
            20                  25                  30          


His Gly Val Gln Ile Pro Pro Thr Glu Leu Pro Ser Tyr Leu Ala Glu 
        35                  40                  45              


Tyr Arg Lys Ala Leu Met Arg Gln Val Val Ala Val Leu Asp Lys Val 
    50                  55                  60                  


Val Gly Lys Arg Arg Arg Leu Ser Gly Met His Pro Glu Ala Tyr Arg 
65                  70                  75                  80  


Asp Arg Val His Leu Ala Glu Ala Leu Trp Val Arg Leu Val Ala Arg 
                85                  90                  95      


Val Lys Glu Ile Gly Thr Pro Pro Asp Pro Ser Glu Leu Leu Asp Leu 
            100                 105                 110         


Arg Arg Met Trp Asn Ala Lys Ala His Pro Tyr Ala Glu Tyr Asp Val 
        115                 120                 125             


Val Pro Arg Ala Pro Leu Asn Asp Gly Asn Gly Gln Lys Ile Leu Glu 
    130                 135                 140                 


Cys Arg Glu Val Asp Asp Pro Lys Ile Glu Arg Ser Asp Phe Glu Gly 
145                 150                 155                 160 


Arg Trp His Gly Arg Phe Trp Gln Ser Glu Pro Gly Pro Val Asp Tyr 
                165                 170                 175     


Asn Ala Ile Ala Asp Arg Ile Phe Ala His Leu Phe Asp Gln Glu Ala 
            180                 185                 190         


Val Ile Gly Gly Gly Pro Arg Arg Glu Gly Asn Val Thr Val Pro Asp 
        195                 200                 205             


Glu Asp Ile Asn Gly Gln Pro Gly Pro Ala Thr Gly Lys Gly Leu Ile 
    210                 215                 220                 


Ile Ala Arg Gly Gln Ser Ile Val Lys Ser Ala Ser Asp Pro Arg Arg 
225                 230                 235                 240 


Ser Ser Lys Lys Val Gln Arg Thr Trp Asp Lys Ala Val Glu Arg Arg 
                245                 250                 255     


Tyr Phe Gly Asp Asp Gly Lys Gly Gly Ser Asp Ile Ala Lys Ala Ile 
            260                 265                 270         


Tyr Glu Glu Leu Gly Asp Pro Ala Thr Leu Ala Asp Pro Ile Tyr Ala 
        275                 280                 285             


Ser Trp Phe Gly Ser Arg Leu Tyr Asp His Phe Gly Ser Phe Lys Asn 
    290                 295                 300                 


Ser Leu Pro Leu Glu Leu Lys Asp Pro Phe Lys Glu Gln Ile Trp Ala 
305                 310                 315                 320 


Leu His Asn Ser Val Arg Gln Phe Tyr Gln Arg Met Ala Lys Ser Asp 
                325                 330                 335     


Arg Phe Arg Leu Ala Leu Gln Asn Ala Arg Ser Glu Val Pro Asp Arg 
            340                 345                 350         


Ser Glu Leu Leu Ala Leu Leu Pro Lys Asp His Asp His Leu Leu Leu 
        355                 360                 365             


Val Leu Gly Gly Lys Lys Lys Asn Ala Glu Met Ser Glu Leu Ile Arg 
    370                 375                 380                 


Leu Gly Lys Leu Phe Val His Ala Ser Asp Val Leu His Asp Phe Asp 
385                 390                 395                 400 


Ala Asn Asp Ala Ala Ala Leu Asp Ala Phe Lys Arg Arg Met Ser Phe 
                405                 410                 415     


Leu Ala Thr Ser Ile Gly Gln Ser Glu Ile Lys Gln Thr Glu Thr Phe 
            420                 425                 430         


Ala Arg Thr Trp Arg Gly Ala Val Gly Leu Thr Leu Arg Thr Val Lys 
        435                 440                 445             


Gly Leu Ala Asp Pro Arg Gly Ile Ile Gly Thr Pro Asp Asn Arg Asp 
    450                 455                 460                 


Leu Gly Thr Ala Gly Pro Met Lys Asp Ala Phe Asn Lys Phe Asp Gln 
465                 470                 475                 480 


Pro His Phe Gln Gln His Met Thr Ile Ile Phe Gly Asn Lys Glu Leu 
                485                 490                 495     


Gln Ala Glu Gly Asn Pro Thr Arg Ser Ser Val Phe Thr Ala Asn Gly 
            500                 505                 510         


Asp Lys Asp His Gln Ala Glu Leu Leu Trp Gly Phe Leu Cys Val Val 
        515                 520                 525             


Arg Ser Val Arg Asn Arg Thr Asn His Tyr Asn Val Arg Arg Ala Leu 
    530                 535                 540                 


Leu Arg Leu Leu Asp Glu Gly Ile Val Ser Pro Met Pro Ser Asp Pro 
545                 550                 555                 560 


Lys Lys Glu Arg Val Glu Asn Arg Asn Leu Cys Thr Val Ser Pro Thr 
                565                 570                 575     


Ala Leu Glu Ala Phe Arg Arg Leu Leu Asn Phe Asp Leu Ala Ile Gln 
            580                 585                 590         


Lys Glu Ala Val Arg Thr Ala Leu Glu Gln Ala Lys Ala Ser Glu Phe 
        595                 600                 605             


Val Glu Glu Gly Lys Leu Arg Gly Leu Val Ser Glu Leu Ala Gly Thr 
    610                 615                 620                 


Glu Asp Met Pro Ala Leu His Ile Pro Arg Phe Ser Ala Val Met Asp 
625                 630                 635                 640 


Lys Val Arg Arg Leu Ala Asp Asn Arg Asp Val Gly Leu Asp Pro Ile 
                645                 650                 655     


Leu Ser Thr Leu Gln Arg Ser Leu Pro Pro Thr Asp Lys Gln Ala Glu 
            660                 665                 670         


Ser Asp Ala Ala Arg Cys Arg Tyr Arg Leu Leu Leu Glu Leu Tyr Lys 
        675                 680                 685             


Ser Gly Phe Arg Ser Trp Phe Ser Gly Ile Gln Ser Asn Glu Glu Asn 
    690                 695                 700                 


Asn Arg Glu Ile Cys His Trp Ala Val Lys Gln Val Gly Arg Ala Lys 
705                 710                 715                 720 


Asp Ala Arg Lys Ser Glu Tyr Asp Lys Lys Thr Lys Arg His Tyr Arg 
                725                 730                 735     


Ser Pro Asn Ser Leu Ile Asp Asp Leu Gly Leu Asp Lys Phe Asp Asp 
            740                 745                 750         


Leu Thr Asp Leu Leu Glu Ala Leu Ala Ser Gln Ser Thr Arg Glu His 
        755                 760                 765             


Asp Gln Asn Leu Lys Tyr Val Pro Asp Ala Arg Val Gln Ser Gln Met 
    770                 775                 780                 


Ser Asn Arg Ile Glu Glu Phe Arg Gln Glu Leu Phe Ala His Ile Phe 
785                 790                 795                 800 


Thr Lys Tyr Leu Asp Thr His Asp Phe Gly Trp Ile Gly Ala Ile Glu 
                805                 810                 815     


Val Arg Arg Glu Ala Cys Asp Leu Ala Asp Val Val Ser Ala Phe Glu 
            820                 825                 830         


Val Arg Asp Gln Lys Phe Asp Ala Asp Trp His Ser Gln Phe Tyr Ala 
        835                 840                 845             


Trp Leu Tyr Met Val Pro Pro Ile Glu Ala Ser Arg Leu Arg His Gln 
    850                 855                 860                 


Met Arg Lys Ser Ala Val Met Asp Asp Lys Trp Ser Thr Thr Leu Glu 
865                 870                 875                 880 


Leu Thr Ser Gly Asp Arg Lys Thr Arg Asp Asp His Ala Gln Asp Val 
                885                 890                 895     


Leu Ala Asp Met Asp Arg Leu Phe Ser Leu Tyr Thr Lys Val Gln Ala 
            900                 905                 910         


Ala Gly Phe Asn Gly Gln Glu His Glu Ser Ala Leu Gly Ser Lys Ser 
        915                 920                 925             


Leu Phe Tyr Glu Asp Gly Asn Gln Phe Asp Glu Val Tyr Ser Pro Asp 
    930                 935                 940                 


Thr Glu Thr His Asn Lys Thr Phe Pro Gly Thr Arg Arg Gly Leu Arg 
945                 950                 955                 960 


Gln Leu Val Arg Tyr Ala His Leu Pro Ala Leu Glu Gly Val Phe Lys 
                965                 970                 975     


Lys His Arg Ile Thr Lys Ala Glu Val Glu Thr Phe Val Ala Leu Tyr 
            980                 985                 990         


Asp Glu Asn Arg Arg Asp Pro Gly  Ser Val Ala His Met  Leu Arg Arg 
        995                 1000                 1005             


Glu Lys  Leu Arg Thr Glu Ile  Leu Arg Ser Ile His  Asp Gly Pro 
    1010                 1015                 1020             


Lys Pro  Lys Asp Lys Asp Phe  Trp Pro Lys Leu Glu  Ala Lys Cys 
    1025                 1030                 1035             


Leu Glu  Tyr Arg Thr Val Ala  Thr Glu Thr Ala Ile  Tyr Asn Phe 
    1040                 1045                 1050             


Gln Ala  Asn Ala Ala Arg Leu  Asn Asp His Ala Arg  Leu His Gln 
    1055                 1060                 1065             


Ile Val  Met Arg Val Val Ala  Arg Leu Thr Asp Tyr  Ala Leu Ile 
    1070                 1075                 1080             


Trp Glu  Arg Asp Arg Leu Phe  Ala Phe Val Gly Met  Leu Tyr Arg 
    1085                 1090                 1095             


Gln Thr  Gly Gly Thr Gly Ile  Asn Pro Ala Met Arg  His Ala Glu 
    1100                 1105                 1110             


Lys Thr  Asn Ala Pro Pro Arg  Ile Gly Ile Leu Val  Ser Asp Ser 
    1115                 1120                 1125             


Ala Leu  Ala Lys Lys Leu Asn  Ser Asn Ser Ala Glu  Val Phe Ile 
    1130                 1135                 1140             


Pro Tyr  Leu Asp Thr Glu Thr  Gly Phe Asp Ala Pro  Arg Phe Asp 
    1145                 1150                 1155             


Asp Leu  Cys Thr Leu Leu Ser  His Glu His Ala Lys  Glu Phe Arg 
    1160                 1165                 1170             


Phe His  Phe Leu Glu Val Gly  Glu Glu Asn Ser Lys  Asp Glu Ala 
    1175                 1180                 1185             


Arg Arg  Leu Asn Glu Glu Thr  Met Gly His Arg Lys  Arg Pro Ala 
    1190                 1195                 1200             


Phe Lys  Arg Gly Thr Arg Arg  Gln Gly Ile Arg Asn  Asp Leu Ala 
    1205                 1210                 1215             


His His  Asn Val Leu Asp Leu  Ala Gly Gly Ala Gly  Pro Asn Leu 
    1220                 1225                 1230             


Thr Tyr  Val Val Asn Ala Val  Arg Ser Leu Leu Ser  Tyr Asp Arg 
    1235                 1240                 1245             


Lys Leu  Lys Asn Ala Val Pro  Lys Ser Ile Lys Arg  Ile Leu Gly 
    1250                 1255                 1260             


Glu Glu  Gly Leu Ile Ile Glu  Trp Gln Met Asn Tyr  Asp Arg Leu 
    1265                 1270                 1275             


Lys Lys  Pro Thr Val Tyr Pro  Asn Val Glu Thr His  Leu Thr Met 
    1280                 1285                 1290             


Val Pro  Pro Arg His Met Thr  Ala Pro Val Ser Phe  Thr Leu Pro 
    1295                 1300                 1305             


Arg Ala  Ser Val Arg Leu Ala  Ser Met Val Lys Ala  Val Phe Asp 
    1310                 1315                 1320             


Phe Gly  Ser Ser Gly Tyr Gly  Glu Glu Arg Met Ile  Gly Gly Arg 
    1325                 1330                 1335             


Thr Ala  Lys Gln Ala Val Tyr  Pro Asp Asp Phe Thr  Arg Arg Phe 
    1340                 1345                 1350             


Pro Gln  Thr Pro Met Gly Leu  Lys Gln Ala Thr Arg  Leu Val Phe 
    1355                 1360                 1365             


Ala Ser  Glu Asn Ser 
    1370             


<210>  909
<211>  1287
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  909

Met Arg Ile Gly Lys Val Gln Gly Arg Thr Phe Thr Gly Phe Asp Asn 
1               5                   10                  15      


Ala Arg Gly Lys Thr Leu Arg Arg Arg Leu Leu Thr Arg Pro Asp Asn 
            20                  25                  30          


Glu Ala Arg Ser Leu Ser Glu His Leu Ala His Asp Pro Lys Ala Leu 
        35                  40                  45              


Ile Gly Gln Ala Ile Ser Arg Ile Asp Thr Ile Tyr Gln Lys Pro Lys 
    50                  55                  60                  


Thr Gly Lys Pro Thr Pro Glu Gln Phe Gly His Arg Asp Thr Leu Gly 
65                  70                  75                  80  


Trp Ala Tyr Trp Lys Leu Leu Val Ala Ser Tyr Pro Glu Val Glu Gly 
                85                  90                  95      


His Arg Asp Leu Phe Val Arg Arg Leu His Pro Tyr Gly Asp Thr Pro 
            100                 105                 110         


Pro Lys Ser His Gly Gln Lys Glu Gly Glu His Gln Lys Gly Gly Lys 
        115                 120                 125             


Pro Gln Leu Glu Gly Arg Trp His Gly Val Met Ala Gln His Gly Lys 
    130                 135                 140                 


Asn Pro Asp Gln Ile Ala Ala Arg Leu Phe Asp His Leu His Asn Ser 
145                 150                 155                 160 


Glu Leu Arg Phe Gly Gly Thr Ala Ser Gly Glu Pro Arg Thr Arg Pro 
                165                 170                 175     


Gly Lys Glu Ala Thr Pro Thr Gly Leu Ile Gly Ala Arg Ala Lys Thr 
            180                 185                 190         


Ile Glu His Ser Val Leu Pro Arg Asp Ala Lys Arg Phe Val Ala Glu 
        195                 200                 205             


Trp Arg Gly Glu Asp Gln Glu Arg Tyr Ala Gly Ala Arg Asp Ile Ala 
    210                 215                 220                 


Ala Ala Ile Ser Ala Gly Leu Asn Asp Lys Asp Gln Lys Ser Gly Ser 
225                 230                 235                 240 


Gly Arg Lys Ser Ala Val Ile Gly Lys Leu Leu Ser Asp His Leu Glu 
                245                 250                 255     


Thr Leu Thr Gly Asn Arg Lys Cys Arg Phe Asp Pro Lys Ser Thr Ala 
            260                 265                 270         


Glu Thr Leu Glu Leu Arg Asp Gly Glu Ser Val Asp Asp Arg Arg Arg 
        275                 280                 285             


Ile Leu Glu Leu His Ala Glu Val Lys Ala Thr Tyr Lys Arg Met Ala 
    290                 295                 300                 


Ala Trp Lys Pro Ala Lys Leu Pro Arg Asn Ser Asp Glu Leu Phe Arg 
305                 310                 315                 320 


Leu Val Arg Gln Gln Ala Asp Asn Arg Ile Leu Asn His Leu Val Arg 
                325                 330                 335     


Val Gly Arg Ile Ser Val Tyr Ser Glu Gln Ser Asp Ala Leu Ser Glu 
            340                 345                 350         


Ser Gln Phe Trp Thr Ser Gly Gly Gln Thr Gln Ile Lys Glu Ser Glu 
        355                 360                 365             


Val Phe Ala Arg Leu Trp Ile Gly Ala Ile Ser Arg Ala Ser Tyr Ser 
    370                 375                 380                 


Met Lys Ala Trp Leu Glu Pro Glu Gly Thr Val Phe Asn Pro Ser Ile 
385                 390                 395                 400 


Asn Asp Phe Asp Val Thr Ser Ser His Asn Thr Asn Arg Ile Leu Glu 
                405                 410                 415     


Asp Ser Gly Arg Leu Ser Asn Ala Met Ala Arg Arg Ala Ile Tyr Phe 
            420                 425                 430         


Gly Glu Thr Pro Glu Phe Asp Ala Leu Gly Glu Glu Asp Gln Arg Val 
        435                 440                 445             


Leu Val Lys Lys Cys Leu Asp Ala Leu Ser Ala Cys Arg Asn Arg Thr 
    450                 455                 460                 


Phe His His Gly Gln Arg Ala Lys Phe Leu Lys Glu Val Arg Lys Gly 
465                 470                 475                 480 


Leu Lys Glu Lys Glu Ala Asp Ser Ala Gly Pro Ala Ala Trp Glu Gly 
                485                 490                 495     


Ile Arg Glu Val Ile Gln Ala Asp Ala Arg Asn Leu Gly Ala Arg Leu 
            500                 505                 510         


Leu Gln Asp Leu Thr Gly Ala Lys Val His Ser Phe Ala Thr Asp Pro 
        515                 520                 525             


Glu Phe Arg His Leu Tyr Glu Ser Val Ala Ala Thr Leu Thr Ala Gly 
    530                 535                 540                 


Gly Glu Leu Glu Ala Ala Leu Pro Arg Leu Lys Asn Val Leu Lys Arg 
545                 550                 555                 560 


Ala Glu Gly Val Arg Cys Tyr Leu Asp Thr Pro Ser Gln Arg Arg Glu 
                565                 570                 575     


Gly Asp Glu Ser Leu Ile Ala Arg Leu Pro Val Ala Pro Val Pro Arg 
            580                 585                 590         


Glu Leu Asp Asp Ala Ala Thr Lys Ala Arg His Ser Ala Leu Leu Arg 
        595                 600                 605             


Leu Tyr Asp Gly Pro Phe Arg Pro Trp Ala Thr Glu Leu Arg Gly Glu 
    610                 615                 620                 


Arg Leu Ser Asp Tyr Ala Ala Arg Ala Lys Arg Leu Ala Thr Arg Leu 
625                 630                 635                 640 


Ala Lys Ser Thr Asn Thr Ala Ser Pro Tyr Pro Asp Ser Val Glu Gly 
                645                 650                 655     


Arg Ser Val Arg Leu Arg Asp Pro Ile Thr Ala Asp Thr Ala Pro Glu 
            660                 665                 670         


Thr Leu Lys Thr Tyr Leu Ser Ala Leu Thr Ala Glu Thr Ala Thr Glu 
        675                 680                 685             


Phe Arg Val Gln Lys Gly Tyr Glu Ser Asp Gly Glu Lys Ala Lys Glu 
    690                 695                 700                 


Gln Ala Glu Phe Ile Glu Asp Phe Arg Arg Asp Met Ile Ala Leu Ala 
705                 710                 715                 720 


Phe Gln Asp Phe Ile Arg Asp His Gly Phe Ala Trp Leu Leu Asp Ile 
                725                 730                 735     


Ala Ser Lys Ala Glu Pro Ser Asn Asp Ala Pro Asn Leu Pro Asp Pro 
            740                 745                 750         


Val Asp Thr Gly Lys Asp Thr Val Phe Glu Asp Trp Gln Ala Leu Leu 
        755                 760                 765             


Tyr Leu Phe Leu His Phe Val Pro Ala Asp Asp Val Ser Gln Leu Leu 
    770                 775                 780                 


His Gln Leu Arg Lys Trp Asp Ala Leu Gln Asp Lys Tyr Glu Leu Ala 
785                 790                 795                 800 


Glu Pro Gly Glu Thr Leu Gly Gln Thr Lys Ala Asp Thr Arg Lys Ile 
                805                 810                 815     


Val Gly Gln Phe Arg Asp Cys Leu Thr Leu Phe Leu Lys Thr Gly Asp 
            820                 825                 830         


Ala Arg Phe Asp Gly Glu Gly Val Glu Leu Pro Leu Ser Asp Phe Gln 
        835                 840                 845             


Glu Leu Phe Glu Ser Pro Ala Thr Phe Lys Glu Leu Phe Leu Ala Glu 
    850                 855                 860                 


Pro Ala Glu Asn Asp Ala Ser Glu Thr Asp Asp Gln Asp Ala Pro Gly 
865                 870                 875                 880 


Glu Lys His Arg Val Thr Arg Thr Arg Arg Gly Leu Arg Gln Ile Leu 
                885                 890                 895     


Arg Tyr Asn His Met Pro Val Leu Arg Asp Leu Phe Leu Ala His Lys 
            900                 905                 910         


Val Thr Asp Ala Glu Val Asp Gly Leu Gln Ala Leu Glu Val Asp Asp 
        915                 920                 925             


Pro Gln Thr Gly Glu Ser Gln Ile Gly Ala Ala Gln Arg Ile Arg Thr 
    930                 935                 940                 


Glu Ile His His His Thr Ser Asn Asp Lys Gln Ile Ser Glu Ala Lys 
945                 950                 955                 960 


Val Glu Glu Tyr Arg Arg Ala Leu Ser Thr Ile Glu Arg His Arg Phe 
                965                 970                 975     


Leu Val Gly Arg Val Tyr Leu Gly Asp His Ile Arg Val His Lys Leu 
            980                 985                 990         


Met Met Asp Val Met Gly Arg Leu  Val Asp Phe Ala Gly  Ala Trp Glu 
        995                 1000                 1005             


Arg Glu  Ala Ala Asp Gly Asp  Arg Lys Gly Phe Ile  Ser Arg Ala 
    1010                 1015                 1020             


Ile Ala  Leu Pro Glu Val Ala  Glu Gly Tyr Ala Ala  Asp Arg Leu 
    1025                 1030                 1035             


Lys Thr  Val Ala Arg Arg Val  Leu Asp Asp Gly Glu  Ala Arg Arg 
    1040                 1045                 1050             


Ile Arg  Asn Asp Leu Gly His  Phe Asn Asp Leu Ala  Pro Thr Ser 
    1055                 1060                 1065             


Gly Pro  Ala Asn Leu Thr Phe  Val Val Asn Arg Ala  Arg Arg Met 
    1070                 1075                 1080             


Met Arg  His Asp Arg Lys Arg  Lys Asn Ala Val Thr  Lys Ser Val 
    1085                 1090                 1095             


Ile Glu  Ile Leu Asn Arg Gln  Gly Leu Gly Ile Glu  Trp Thr Met 
    1100                 1105                 1110             


Arg Asn  His Glu Leu Cys Glu  Ala Lys Leu Trp Gln  Asn Pro Val 
    1115                 1120                 1125             


Lys His  Leu Gly Phe Ala Thr  Leu Glu Gly Arg Gly  Lys Lys Trp 
    1130                 1135                 1140             


Arg Arg  Pro Phe Glu Ala Arg  Tyr Gly Asp Ala Tyr  Met Ala Met 
    1145                 1150                 1155             


Val Ala  Gln Leu Phe Asp Gly  Thr Val Thr Ser Pro  Pro Ala Lys 
    1160                 1165                 1170             


Gly Pro  Pro Gln Ser Gly Lys  Ser Gly Gly Lys Pro  Gly Lys Gly 
    1175                 1180                 1185             


Ala Glu  Gly Gly Ala Lys Glu  Lys Ser Arg Ser Pro  Thr Arg Met 
    1190                 1195                 1200             


Glu Glu  Gly Gly Val Tyr Glu  Gly Arg Val Ala Lys  Ala Lys Ser 
    1205                 1210                 1215             


Asp Lys  Gly Phe Gly Phe Leu  Leu Val Glu Gly Ala  Gln Glu Glu 
    1220                 1225                 1230             


Ile Phe  Leu His Ile Tyr Gly  Ile Ser Gly Asn Arg  Pro Ala Arg 
    1235                 1240                 1245             


Ile Glu  Asn Gly Gln Arg Tyr  Arg Phe Thr Leu Gly  Ile Asp Arg 
    1250                 1255                 1260             


Asp Arg  Glu Arg Arg Lys Glu  Arg Ala Trp Val Ala  Arg Glu Ala 
    1265                 1270                 1275             


Val Arg  Ile Asp Glu Asn Arg  Ser Lys 
    1280                 1285         


<210>  910
<211>  1373
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  910

Met Ala Lys His Leu Arg Pro Ile Gly Glu Ser Tyr Thr Asp Phe Leu 
1               5                   10                  15      


Asp Glu Thr Glu Phe Val Arg Leu Gly Arg Gly Leu His Arg Gly His 
            20                  25                  30          


His Gly Val Gln Ile Pro Pro Thr Glu Leu Pro Ser Tyr Leu Ala Glu 
        35                  40                  45              


Tyr Arg Lys Ala Leu Met Arg Gln Val Val Ala Val Leu Asp Lys Val 
    50                  55                  60                  


Val Gly Lys Arg Arg Arg Leu Ser Gly Met His Pro Glu Ala Tyr Arg 
65                  70                  75                  80  


Asp Arg Val His Leu Ala Glu Ala Leu Trp Val Arg Leu Val Ala Arg 
                85                  90                  95      


Val Lys Glu Ile Gly Thr Pro Pro Asp Pro Ser Glu Leu Leu Asp Leu 
            100                 105                 110         


Arg Arg Met Trp Asn Ala Lys Ala His Pro Tyr Ala Glu Tyr Asp Val 
        115                 120                 125             


Val Pro Arg Ala Pro Leu Asn Asp Gly Asn Gly Gln Lys Ile Leu Glu 
    130                 135                 140                 


Cys Arg Glu Val Asp Asp Pro Lys Ile Glu Arg Ser Asp Phe Glu Gly 
145                 150                 155                 160 


Arg Trp His Gly Arg Phe Trp Gln Ser Glu Pro Gly Pro Val Asp Tyr 
                165                 170                 175     


Asn Ala Ile Ala Asp Arg Ile Phe Ala His Leu Phe Asp Gln Glu Ala 
            180                 185                 190         


Val Ile Gly Gly Gly Pro Arg Arg Glu Gly Asn Val Thr Val Pro Asp 
        195                 200                 205             


Glu Asp Ile Asn Gly Gln Pro Gly Pro Ala Thr Gly Lys Gly Leu Ile 
    210                 215                 220                 


Ile Ala Arg Gly Gln Ser Ile Val Lys Ser Ala Ser Asp Pro Arg Arg 
225                 230                 235                 240 


Ser Ser Lys Lys Val Gln Arg Thr Trp Asp Lys Ala Val Glu Arg Arg 
                245                 250                 255     


Tyr Phe Gly Asp Asp Gly Lys Gly Gly Ser Asp Ile Ala Lys Ala Ile 
            260                 265                 270         


Tyr Glu Glu Leu Gly Asp Pro Ala Thr Leu Ala Asp Pro Ile Tyr Ala 
        275                 280                 285             


Ser Trp Phe Gly Ser Arg Leu Tyr Asp His Phe Gly Ser Phe Lys Asn 
    290                 295                 300                 


Ser Leu Pro Leu Glu Leu Lys Asp Pro Phe Lys Glu Gln Ile Trp Ala 
305                 310                 315                 320 


Leu His Asn Ser Val Arg Gln Phe Tyr Gln Arg Met Ala Lys Ser Asp 
                325                 330                 335     


Arg Phe Arg Leu Ala Leu Gln Asn Ala Arg Ser Glu Val Pro Asp Arg 
            340                 345                 350         


Ser Glu Leu Leu Ala Leu Leu Pro Lys Asp His Asp His Leu Leu Leu 
        355                 360                 365             


Val Leu Gly Gly Lys Lys Lys Asn Ala Glu Met Ser Glu Leu Ile Arg 
    370                 375                 380                 


Leu Gly Lys Leu Phe Val His Ala Ser Asp Val Leu His Asp Phe Asp 
385                 390                 395                 400 


Ala Asn Asp Ala Ala Ala Leu Asp Ala Phe Lys Arg Arg Met Ser Phe 
                405                 410                 415     


Leu Ala Thr Ser Ile Gly Gln Ser Glu Ile Lys Gln Thr Glu Thr Phe 
            420                 425                 430         


Ala Arg Thr Trp Arg Gly Ala Val Gly Leu Thr Leu Arg Thr Val Lys 
        435                 440                 445             


Gly Leu Ala Asp Pro Arg Gly Ile Ile Gly Thr Pro Asp Asn Arg Asp 
    450                 455                 460                 


Leu Gly Thr Ala Gly Pro Met Lys Asp Ala Phe Asn Lys Phe Asp Gln 
465                 470                 475                 480 


Pro His Phe Gln Gln His Met Thr Ile Ile Phe Gly Asn Lys Glu Leu 
                485                 490                 495     


Gln Ala Glu Gly Asn Pro Thr Arg Ser Ser Val Phe Thr Ala Asn Gly 
            500                 505                 510         


Asp Lys Asp His Gln Ala Glu Leu Leu Trp Gly Phe Leu Cys Val Val 
        515                 520                 525             


Arg Ser Val Arg Asn Arg Thr Asn His Tyr Asn Val Arg Arg Ala Leu 
    530                 535                 540                 


Leu Arg Leu Leu Asp Glu Gly Ile Val Ser Pro Met Pro Ser Asp Pro 
545                 550                 555                 560 


Lys Lys Glu Arg Val Glu Asn Arg Asn Leu Cys Thr Val Ser Pro Thr 
                565                 570                 575     


Ala Leu Glu Ala Phe Arg Arg Leu Leu Asn Phe Asp Leu Ala Ile Gln 
            580                 585                 590         


Lys Glu Ala Val Arg Thr Ala Leu Glu Gln Ala Lys Ala Ser Glu Phe 
        595                 600                 605             


Val Glu Glu Gly Lys Leu Arg Gly Leu Val Ser Glu Leu Ala Gly Thr 
    610                 615                 620                 


Glu Asp Met Pro Ala Leu His Ile Pro Arg Phe Ser Ala Val Met Asp 
625                 630                 635                 640 


Lys Val Arg Arg Leu Ala Asp Asn Arg Asp Val Gly Leu Asp Pro Ile 
                645                 650                 655     


Leu Ser Thr Leu Gln Arg Ser Leu Pro Pro Thr Asp Lys Gln Ala Glu 
            660                 665                 670         


Ser Asp Ala Ala Arg Cys Arg Tyr Arg Leu Leu Leu Glu Leu Tyr Lys 
        675                 680                 685             


Ser Gly Phe Arg Ser Trp Phe Ser Gly Ile Gln Ser Asn Glu Glu Asn 
    690                 695                 700                 


Asn Arg Glu Ile Cys His Trp Ala Val Lys Gln Val Gly Arg Ala Lys 
705                 710                 715                 720 


Asp Ala Arg Lys Ser Glu Tyr Asp Lys Lys Thr Lys Arg His Tyr Arg 
                725                 730                 735     


Ser Pro Asn Ser Leu Ile Asp Asp Leu Gly Leu Asp Lys Phe Asp Asp 
            740                 745                 750         


Leu Thr Asp Leu Leu Glu Ala Leu Ala Ser Gln Ser Thr Arg Glu His 
        755                 760                 765             


Asp Gln Asn Leu Lys Tyr Val Pro Asp Ala Arg Val Gln Ser Gln Met 
    770                 775                 780                 


Ser Asn Arg Ile Glu Glu Phe Arg Gln Glu Leu Phe Ala His Ile Phe 
785                 790                 795                 800 


Thr Lys Tyr Leu Asp Thr His Asp Phe Gly Trp Ile Gly Ala Ile Glu 
                805                 810                 815     


Val Arg Arg Glu Ala Cys Asp Leu Ala Asp Val Val Ser Ala Phe Glu 
            820                 825                 830         


Val Arg Asp Gln Lys Phe Asp Ala Asp Trp His Ser Gln Phe Tyr Ala 
        835                 840                 845             


Trp Leu Tyr Met Val Pro Pro Ile Glu Ala Ser Arg Leu Arg His Gln 
    850                 855                 860                 


Met Arg Lys Ser Ala Val Met Asp Asp Lys Trp Ser Thr Thr Leu Glu 
865                 870                 875                 880 


Leu Thr Ser Gly Asp Arg Lys Thr Arg Asp Asp His Ala Gln Asp Val 
                885                 890                 895     


Leu Ala Asp Met Asp Arg Leu Phe Ser Leu Tyr Thr Lys Val Gln Ala 
            900                 905                 910         


Ala Gly Phe Asn Gly Gln Glu His Glu Ser Ala Leu Gly Ser Lys Ser 
        915                 920                 925             


Leu Phe Tyr Glu Asp Gly Asn Gln Phe Asp Glu Val Tyr Ser Pro Asp 
    930                 935                 940                 


Thr Glu Thr His Asn Lys Thr Phe Pro Gly Thr Arg Arg Gly Leu Arg 
945                 950                 955                 960 


Gln Leu Val Arg Tyr Ala His Leu Pro Ala Leu Glu Gly Val Phe Lys 
                965                 970                 975     


Lys His Arg Ile Thr Lys Ala Glu Val Glu Thr Phe Val Ala Leu Tyr 
            980                 985                 990         


Asp Glu Asn Arg Arg Asp Pro Gly  Ser Val Ala His Met  Leu Arg Arg 
        995                 1000                 1005             


Glu Lys  Leu Arg Thr Glu Ile  Leu Arg Ser Ile His  Asp Gly Pro 
    1010                 1015                 1020             


Lys Pro  Lys Asp Lys Asp Phe  Trp Pro Lys Leu Glu  Ala Lys Cys 
    1025                 1030                 1035             


Leu Glu  Tyr Arg Thr Val Ala  Thr Glu Thr Ala Ile  Tyr Asn Phe 
    1040                 1045                 1050             


Gln Ala  Asn Ala Ala Arg Leu  Asn Asp His Ala Arg  Leu His Gln 
    1055                 1060                 1065             


Ile Val  Met Arg Val Val Ala  Arg Leu Thr Asp Tyr  Ala Leu Ile 
    1070                 1075                 1080             


Trp Glu  Arg Asp Arg Leu Phe  Ala Phe Val Gly Met  Leu Tyr Arg 
    1085                 1090                 1095             


Gln Thr  Gly Gly Thr Gly Ile  Asn Pro Ala Met Arg  His Ala Glu 
    1100                 1105                 1110             


Lys Thr  Asn Ala Pro Pro Arg  Ile Gly Ile Leu Val  Ser Asp Ser 
    1115                 1120                 1125             


Ala Leu  Ala Lys Lys Leu Asn  Ser Asn Ser Ala Glu  Val Phe Ile 
    1130                 1135                 1140             


Pro Tyr  Leu Asp Thr Glu Thr  Gly Phe Asp Ala Pro  Arg Phe Asp 
    1145                 1150                 1155             


Asp Leu  Cys Thr Leu Leu Ser  His Glu His Ala Lys  Glu Phe Arg 
    1160                 1165                 1170             


Phe His  Phe Leu Glu Val Gly  Glu Glu Asn Ser Lys  Asp Glu Ala 
    1175                 1180                 1185             


Arg Arg  Leu Asn Glu Glu Thr  Met Gly His Arg Lys  Arg Pro Ala 
    1190                 1195                 1200             


Phe Lys  Arg Gly Thr Arg Arg  Gln Gly Ile Arg Asn  Asp Leu Ala 
    1205                 1210                 1215             


His His  Asn Val Leu Asp Leu  Ala Gly Gly Ala Gly  Pro Asn Leu 
    1220                 1225                 1230             


Thr Tyr  Val Val Asn Ala Val  Arg Ser Leu Leu Ser  Tyr Asp Arg 
    1235                 1240                 1245             


Lys Leu  Lys Asn Ala Val Pro  Lys Ser Ile Lys Arg  Ile Leu Gly 
    1250                 1255                 1260             


Glu Glu  Gly Leu Ile Ile Glu  Trp Gln Met Asn Tyr  Asp Arg Leu 
    1265                 1270                 1275             


Lys Lys  Pro Thr Val Tyr Pro  Asn Val Glu Thr His  Leu Thr Met 
    1280                 1285                 1290             


Val Pro  Pro Arg His Met Thr  Ala Pro Val Ser Phe  Thr Leu Pro 
    1295                 1300                 1305             


Arg Ala  Ser Val Arg Leu Ala  Ser Met Val Lys Ala  Val Phe Asp 
    1310                 1315                 1320             


Phe Gly  Ser Ser Gly Tyr Gly  Glu Glu Arg Met Ile  Gly Gly Arg 
    1325                 1330                 1335             


Thr Ala  Lys Gln Ala Val Tyr  Pro Asp Asp Phe Thr  Arg Arg Phe 
    1340                 1345                 1350             


Pro Gln  Thr Pro Met Gly Leu  Lys Gln Ala Thr Arg  Leu Val Phe 
    1355                 1360                 1365             


Ala Ser  Glu Asn Ser 
    1370             


<210>  911
<211>  1170
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  911

Met Lys Ile Thr Lys Asn Thr Lys Asn Gly Lys Leu Glu Phe Tyr Arg 
1               5                   10                  15      


Asp Val Lys Glu Gly Gly Leu Arg Asp Pro Lys Ser Lys Thr Ile Trp 
            20                  25                  30          


Thr Ser Glu Thr Ile Lys Arg Leu Asp Ile Asn Lys Ser Leu Lys Gly 
        35                  40                  45              


Arg Ile Leu Ala Tyr Gly Thr Ser Leu Gly Ser Ser Asn Pro Tyr Ser 
    50                  55                  60                  


Val Phe Val Asp Ser Leu Ile Arg Glu Asn Lys Glu Ile Ser Leu Ser 
65                  70                  75                  80  


Glu Leu Lys Arg Glu Gln Cys Lys Lys Glu Asn Val Gln Lys Tyr Leu 
                85                  90                  95      


Ser Ala Tyr Gly Arg Met Ile Asn Tyr Cys Thr Glu Glu Asn Thr Ser 
            100                 105                 110         


Leu Gly Asn Leu Leu Val Glu Tyr Gly Asn Gly Ala Glu Ile Ser Glu 
        115                 120                 125             


Ala Leu Val Gln Ile Lys Lys Gln Ile Leu Lys Leu Lys Arg His Lys 
    130                 135                 140                 


Lys Lys Ser Leu Leu Asp Ser Phe Met Asn Asn Lys Ile Pro Phe Lys 
145                 150                 155                 160 


Leu Thr Asn Gly Lys Leu Glu Pro Ala Thr Asp Lys Met Ser Arg Leu 
                165                 170                 175     


Phe Ser Leu Leu Glu Glu Asp Gly Val Asp Lys Asn Lys Phe Glu Lys 
            180                 185                 190         


Tyr Lys Thr Trp Tyr Gln Tyr Glu Val Leu Lys Lys Arg Leu Asp Leu 
        195                 200                 205             


Ile Cys Glu Glu His Phe Ser Ala Ala Glu Arg Lys Pro Arg Val Leu 
    210                 215                 220                 


Ala Lys Lys Ile Tyr Ser Ala Val Lys Leu Tyr Asn Lys Glu Lys Ala 
225                 230                 235                 240 


Asn Ser Asp Val Ile Lys Asn Lys Asp Asp Ala His Ser Leu Phe Leu 
                245                 250                 255     


Asp Glu Ile Arg Asp His Phe Arg Lys Tyr Phe Pro Val Thr Gly Lys 
            260                 265                 270         


Lys Gly Leu Ser Ser Gly Gly Asp Ser Glu Lys Leu Asn Ser Leu Ala 
        275                 280                 285             


Ser Glu Lys Asn Val Lys Tyr Tyr Tyr Ser Asp Lys Tyr Val Phe Gln 
    290                 295                 300                 


Gln Val Trp Arg Gln Ile Val Asn Gln Leu Thr Ala Gly Leu Ile Gln 
305                 310                 315                 320 


Tyr Gly Lys Leu Ser Tyr Tyr Phe His Asp Lys Glu Asn His Thr Trp 
                325                 330                 335     


Gln Glu Glu Lys Leu Asn Ser Glu Gly Met Gln Glu Ile Gln Val Arg 
            340                 345                 350         


Glu Thr Phe Lys Lys Gln Leu Phe Leu Ser Val Val Trp Ser Val Asn 
        355                 360                 365             


Lys Leu Asn Tyr Phe Phe Gln Tyr Gly Gly Glu Asn Pro Lys Met Leu 
    370                 375                 380                 


Tyr Gln Val Lys Tyr Asp Glu Asp Cys Ile Ala Gly Asp Ile Ile Glu 
385                 390                 395                 400 


Glu Leu Arg Lys Ala Asp Phe Ser Arg Phe Cys Tyr Asp Asp Pro Ile 
                405                 410                 415     


Lys Asn Asn Tyr Ile His Arg Phe Met His Gly Ile Lys Glu Glu Pro 
            420                 425                 430         


Glu Lys Phe Glu Leu Leu Phe Asp Lys Met Ser Val Ser Tyr Pro Leu 
        435                 440                 445             


Glu Glu Glu Asp Lys Asn Pro Glu Glu Ile Leu Lys Val Leu Gln Glu 
    450                 455                 460                 


Ile Asn Cys Ser Val Thr Asp Leu Arg His Ser Ile Ile His Tyr Gln 
465                 470                 475                 480 


Lys Asp Val Val Tyr Gln Glu Thr Gln Gly Pro Lys Tyr Pro Lys Ala 
                485                 490                 495     


Ser Glu Phe Leu Arg Arg Asp Ile Asp Asn Ile Glu Asn Cys Phe Leu 
            500                 505                 510         


Glu Gln Ile Arg Ser Met Ser Leu Ala Glu Tyr Tyr Pro Leu Asp Leu 
        515                 520                 525             


Leu Gln Lys Val Phe Lys Asp Cys Asn Leu Asn Phe Gln Leu Tyr Ala 
    530                 535                 540                 


Ser Gln Val Pro Met Val Pro Ser Phe Gln Lys Val Phe Gly Lys Gly 
545                 550                 555                 560 


Val Asn Leu Tyr Lys Ala Asp Gln Lys Ser Gly Ser Leu Lys Trp Tyr 
                565                 570                 575     


Met Glu Glu Arg Lys Asp Pro Glu Ala Lys Leu Ala Thr Leu Ala Tyr 
            580                 585                 590         


Arg Asn Phe Ile Gln Leu Ile Tyr Tyr His Gly Phe Leu Pro Ala Val 
        595                 600                 605             


Glu Lys Asn Asn Ala Leu Val Thr Asp Phe Ile Asn Glu Thr Val Glu 
    610                 615                 620                 


Trp Asn Gln Glu Arg Ser Leu Gln Ser Gln Arg Glu Asp Pro Glu Thr 
625                 630                 635                 640 


Lys Tyr Ile Asn Phe Ser Lys Tyr Arg Tyr Gln Gly Met Pro Glu Phe 
                645                 650                 655     


Gln Asn Lys Ser Leu Leu Glu Tyr Met Ser Glu Leu Gln Arg Asp Gln 
            660                 665                 670         


Ser Asn Lys Glu Lys Glu Asp Ser Lys Ala Gly Val Pro Glu Asp Lys 
        675                 680                 685             


Lys Lys Arg Tyr Tyr Thr Lys Phe Ile Gln Asp Ile Phe Ala Phe Ser 
    690                 695                 700                 


Phe Gly Ser Phe Leu Asn Ser Lys Leu Asn Glu Cys Arg Glu Asp Leu 
705                 710                 715                 720 


Leu Gln Pro Arg Tyr Gln Glu Ile Lys Thr Asn Glu Asp Arg Glu Gln 
                725                 730                 735     


Arg Leu Lys Lys Leu Leu Glu Asp Leu Glu Met Lys Thr Asn Ile Lys 
            740                 745                 750         


Asn Gly Ser Pro Thr Gln Leu Ala Met Tyr Pro Phe Leu Lys Leu Leu 
        755                 760                 765             


Asp Gln Arg Gly Leu Asn Gln Leu Leu His Gln Phe Ile Arg Cys Ser 
    770                 775                 780                 


Ala Ser Val Lys Ser Gly Phe Met Gln Asp Asp Lys Ala Leu Asn Leu 
785                 790                 795                 800 


Asn Arg Glu Ile Glu Glu Leu Ile Ala Leu Val Ala Phe Thr Lys Arg 
                805                 810                 815     


Pro Leu Met Asn Thr Glu Ala Tyr Ser Arg Ala Ile Glu Met Leu Ser 
            820                 825                 830         


Glu Thr Phe Ile Glu Gly Glu Ile Lys Asp Tyr Ala Asp Leu Tyr Tyr 
        835                 840                 845             


Gln Ser Asp Gln Glu His Ser Val Leu His Arg Asn Ile Ala Tyr Met 
    850                 855                 860                 


Gly Gly Thr Gly Val Ile Ala Leu Tyr Ser Asp Val Leu Arg Asp Cys 
865                 870                 875                 880 


Tyr Arg Val Lys Lys Thr Asp Tyr Val Glu Tyr Lys Lys Ala Asn Ser 
                885                 890                 895     


Lys Glu Asn Gly Arg Gln Phe Thr Arg Ile Gly Glu Asp Gln Lys Arg 
            900                 905                 910         


Leu Gln Asp Leu His Glu Ser Leu Ile Gly Arg Tyr Asn Ser Gly Gln 
        915                 920                 925             


Ile Gln Glu Tyr Lys Lys Leu Leu Arg Lys Thr His Glu Tyr Asn Val 
    930                 935                 940                 


Leu Lys Lys Arg Ile Thr Phe Glu Asn Met Tyr Glu Ile Tyr Gln Leu 
945                 950                 955                 960 


His Thr Glu Leu Leu Gly Arg Leu Ala Ser Phe Ala Glu Asp Trp Glu 
                965                 970                 975     


Arg Asp Met Leu Phe Leu Leu Thr Gly Leu Glu Ser Arg Gly Leu Ile 
            980                 985                 990         


Glu Asp Arg Val Glu Lys Ile Phe  Leu Lys Asp Lys Gly  Gly Val Val 
        995                 1000                 1005             


Ala Lys  Met Asn Lys Asn Leu  Lys Asp Asn Glu Lys  Leu Leu Lys 
    1010                 1015                 1020             


Ser Leu  Tyr Cys Arg Glu Asp  Gln Glu Ser Thr Asp  Phe Trp Lys 
    1025                 1030                 1035             


Thr Phe  His Val Arg Asn Ala  Val Ala His Phe Asn  His Phe Thr 
    1040                 1045                 1050             


Gln Lys  Ser Gln Ser Lys Gly  Gly Ser Val Val Tyr  Gln Arg Ser 
    1055                 1060                 1065             


Ile Glu  Glu Leu Ile Asn Arg  Ile Arg Gly Leu Leu  Ala Tyr Asp 
    1070                 1075                 1080             


Met Lys  Arg Gln Asn Ala Val  Thr Gln Ala Val Gln  Lys Ile Phe 
    1085                 1090                 1095             


Asp Lys  His Gln Met Ile Ile  Lys Phe Lys Pro Val  Thr Ile Asn 
    1100                 1105                 1110             


Ser Asp  Pro Glu Lys Trp Val  Gly Thr Trp Asn Ile  Glu Phe Gly 
    1115                 1120                 1125             


Ile Asp  Cys Ile Arg Ser Lys  Asn Ile Val His Phe  Lys Asn Leu 
    1130                 1135                 1140             


Ser Asp  Arg Ile Cys Leu Ile  Glu Ala His Asp Arg  Asn Thr Ile 
    1145                 1150                 1155             


Lys Ala  Ile Glu Lys Leu Met  Lys Phe Lys Tyr Asn  
    1160                 1165                 1170 


<210>  912
<211>  949
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  912

Met Pro His Gln Lys Lys Met Ala Glu Arg Ile Lys Phe Val Asn Tyr 
1               5                   10                  15      


Gly Tyr Tyr Leu Arg Leu Lys Lys Asn Cys Ala Asp Ser Phe Glu Tyr 
            20                  25                  30          


Tyr Trp Cys Asp Tyr Ile Lys Glu Phe Ile Glu Glu Asn Tyr Val Thr 
        35                  40                  45              


Lys Ile Lys Glu Ala Lys Gly Lys Asn Gly Arg Gln Leu Thr Glu Glu 
    50                  55                  60                  


Asn Cys Asn Ser Glu Ala Met Leu Ser Lys Cys Trp His Asp Met Ile 
65                  70                  75                  80  


Arg His Met Cys Ala Lys Tyr Met Asp Leu Gly Lys Ala Val Tyr His 
                85                  90                  95      


Phe Met Leu Pro Gly Lys Ala Glu Gly Asn Asp Leu Cys Leu Asp Arg 
            100                 105                 110         


Leu Asn Asp Ser Phe Ser Lys Gly Ile Thr Ser Phe Asp Tyr Glu Asn 
        115                 120                 125             


Ile Lys Ala Glu Glu Asn Leu Gln Lys Ala Met Phe Gly Val Leu Val 
    130                 135                 140                 


Ser Gly Thr Phe Asn Phe Ser Arg Ser Val Ala Asp Tyr Ser Gly Pro 
145                 150                 155                 160 


Ala Ala Ala Lys Leu Ala Lys Glu Leu Arg Ala Glu Gly Lys Thr Leu 
                165                 170                 175     


Asn Glu Asp Val Leu Met Val Asp Glu Ala His Leu Lys Ala Ile Leu 
            180                 185                 190         


Tyr Ser Asp Ala Lys Arg Lys Leu Leu Arg Tyr Phe Gly Gly Ser Ser 
        195                 200                 205             


Ala Cys Glu Ala Leu Gly Leu Asp Lys Asp Lys Met Val Leu Glu Phe 
    210                 215                 220                 


Arg Gln Ile Phe Arg Gly Leu Arg Asn Ser Ala Phe His Tyr Thr Asp 
225                 230                 235                 240 


Gly Lys Lys Ala Asp Ile Lys Phe Asp Val Thr Arg Gln Leu Trp Ile 
                245                 250                 255     


Gln Asp Val Gln Ala Asn Lys Gln Leu Ile Leu Asp Lys Tyr Tyr Ser 
            260                 265                 270         


Asn Asn Val Cys Arg Tyr Tyr Lys Pro Glu Met Val Lys Lys Leu Ile 
        275                 280                 285             


Gly Asn Leu Tyr His Gly Tyr Val Glu Gln Glu Ala Gln Ile Pro Ala 
    290                 295                 300                 


Phe Arg Thr Val Trp Lys Arg Lys Asp Phe Ala Lys Tyr Leu Asn Asp 
305                 310                 315                 320 


Ser Asn Phe Leu Pro Val Asn Ile Lys Asn Asp Val Lys Glu Arg Thr 
                325                 330                 335     


Val Phe Glu Gly Ala Leu Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg 
            340                 345                 350         


Lys Tyr Thr Val Gly Gln Asp Ala Pro Lys Tyr Phe Phe Glu Ala Val 
        355                 360                 365             


Arg Ala Tyr Ser Asp Glu His Ala Lys Asn Lys Gln Asp Pro Tyr Ala 
    370                 375                 380                 


Asn Gln Ala Lys Asn Phe Trp Asp Tyr Val Glu Lys Leu Gln Lys Ser 
385                 390                 395                 400 


Tyr Glu Lys Gly Thr Leu Thr Phe Gly Ala Val Cys Gln Thr Ile Met 
                405                 410                 415     


Thr Glu Phe Val Gln Gln Asn Ser Lys Ala Thr Glu Lys Glu Gly Glu 
            420                 425                 430         


Ile Tyr Gln His Phe Lys Val Leu Phe Pro Leu Cys Met Gln Arg Gly 
        435                 440                 445             


Phe Glu Lys Tyr Val Lys Glu Lys His Gly Tyr Leu Leu Lys Pro Trp 
    450                 455                 460                 


Leu Asp Thr Val Val Arg Glu Asn Val Leu Gln Asp Ala Ala Ile Thr 
465                 470                 475                 480 


Cys Phe Asp Asp Leu Met Arg Asp Ala Glu Asp Arg Glu Tyr Ser Trp 
                485                 490                 495     


Tyr Val Val Ala His Phe Ile His Pro Lys Lys Leu Asn His Phe Val 
            500                 505                 510         


Gly Ala Leu Lys Asp Tyr Leu Gln Phe Lys Gln Asp Ile Phe Arg Arg 
        515                 520                 525             


Cys Ser Phe Ala Asn Ile Tyr Ser Glu Gly Glu Leu Ser Gln Lys Lys 
    530                 535                 540                 


Ala Met Leu Ala Glu Lys Glu Ala Glu Ile Ser Glu Ile Leu Arg Val 
545                 550                 555                 560 


Met Glu Phe Val Arg Gly Ile Thr Gly Arg Val Ser Lys Thr Phe Ser 
                565                 570                 575     


Asp Tyr Tyr Glu Asn Glu Glu Val Tyr Ala Asn Tyr Leu Gly Lys Tyr 
            580                 585                 590         


Ile Asp Phe Pro Lys Thr Asp Gly Ile Ser Val Phe Glu Ser Phe Arg 
        595                 600                 605             


Asp Phe Cys Thr Asn Thr Leu Pro Asp Gly Asn Val Leu Asp Val Tyr 
    610                 615                 620                 


Met Asp Glu Lys Asn Pro Arg Leu Leu Lys Asn Val Glu Leu Ala Arg 
625                 630                 635                 640 


Met Tyr Ala Gly Gly Asp Val Ala Leu Lys Lys Arg Lys Arg Ile Thr 
                645                 650                 655     


Ala Lys Asp Leu Gln Arg Tyr Tyr Gly Asn Glu Val Ala Val Gln Lys 
            660                 665                 670         


Ile Leu Gln Lys Gly Leu Cys Ser Thr Arg Glu Glu Gln Gln Arg Val 
        675                 680                 685             


Leu Glu Gln Gln Asn Leu Arg Gly Arg Ile Thr Leu Asn Asp Val Thr 
    690                 695                 700                 


Glu Ile Gln Glu Ile Ile Ser Asp Met Leu Ser Gln Leu Val Thr Phe 
705                 710                 715                 720 


Ser Tyr Phe Arg Glu Arg Asp Gln Met Tyr Leu Leu Leu Gly Phe Tyr 
                725                 730                 735     


Tyr Met Ala Leu Gln Thr Asn Arg Gly Ser Ser Trp Gly Asn Glu Thr 
            740                 745                 750         


Ile Asp Phe Cys Ala Gly Lys Lys Ile Ser Ile Lys Gln Gly Trp Val 
        755                 760                 765             


Leu His Gln Val Arg Ser Val Phe Thr Tyr Gly Leu Lys Leu Tyr Ser 
    770                 775                 780                 


Glu Leu Asp Glu Lys Gly Val Gly Gly Gln Leu Ser Ser Lys Ile Val 
785                 790                 795                 800 


Ala Phe Glu Arg Val His Arg Thr Ser Leu Ala Cys Ala Leu Arg Leu 
                805                 810                 815     


Phe Met Asp Glu Asn Cys Ser Arg Arg Ala Val Asp Val Arg Asn Tyr 
            820                 825                 830         


Val Asp His Phe Lys Tyr Tyr Phe Lys Ala Asp Arg Ser Ile Met Glu 
        835                 840                 845             


Leu Tyr Ser Ala Tyr Tyr Asp Cys Phe Phe Asp Tyr Ser Thr Lys Met 
    850                 855                 860                 


Arg Lys Ser Val Leu Leu Asn Phe Ile Ser Ile Leu Glu Arg His Phe 
865                 870                 875                 880 


Val Val Ser Lys Leu Arg Val Asn Cys Leu Glu Glu Arg Cys Ser Val 
                885                 890                 895     


Ser Phe Ala Glu Ser Leu Lys Ser Glu Lys Phe Thr Tyr Lys Leu Glu 
            900                 905                 910         


Ala Asp Ala Asn Lys Lys Ser Lys Glu Gln Thr Val Glu Phe Pro Ala 
        915                 920                 925             


Arg Asp Lys Glu Phe Leu Glu Ser Leu Gln Ala Glu Leu Glu Tyr Lys 
    930                 935                 940                 


Glu Gly Tyr Asn Ser 
945                 


<210>  913
<211>  949
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  913

Met Pro His Gln Lys Lys Met Ala Glu Arg Ile Lys Phe Val Asn Tyr 
1               5                   10                  15      


Gly Tyr Tyr Leu Arg Leu Lys Lys Asn Cys Ala Asp Ser Phe Glu Tyr 
            20                  25                  30          


Tyr Trp Cys Asp Tyr Ile Lys Glu Phe Ile Glu Glu Asn Tyr Val Thr 
        35                  40                  45              


Lys Ile Lys Glu Ala Lys Gly Lys Asn Gly Arg Gln Leu Thr Glu Glu 
    50                  55                  60                  


Asn Cys Asn Ser Glu Ala Met Leu Ser Lys Cys Trp His Asp Met Ile 
65                  70                  75                  80  


Arg His Met Cys Ala Lys Tyr Met Asp Leu Gly Lys Ala Val Tyr His 
                85                  90                  95      


Phe Met Leu Pro Gly Lys Ala Glu Gly Asn Asp Leu Cys Leu Asp Arg 
            100                 105                 110         


Leu Asn Asp Ser Phe Ser Lys Gly Ile Thr Ser Phe Asp Tyr Glu Asn 
        115                 120                 125             


Ile Lys Ala Glu Glu Asn Leu Gln Lys Ala Met Phe Gly Val Leu Val 
    130                 135                 140                 


Ser Gly Thr Phe Asn Phe Ser Arg Ser Val Ala Asp Tyr Ser Gly Pro 
145                 150                 155                 160 


Ala Ala Ala Lys Leu Ala Lys Glu Leu Arg Ala Glu Gly Lys Thr Leu 
                165                 170                 175     


Asn Glu Asp Val Leu Met Val Asp Glu Ala His Leu Lys Ala Ile Leu 
            180                 185                 190         


Tyr Ser Asp Ala Lys Arg Lys Leu Leu Arg Tyr Phe Gly Gly Ser Ser 
        195                 200                 205             


Ala Cys Glu Ala Leu Gly Leu Asp Lys Asp Lys Met Val Leu Glu Phe 
    210                 215                 220                 


Arg Gln Ile Phe Arg Gly Leu Arg Asn Ser Ala Phe His Tyr Thr Asp 
225                 230                 235                 240 


Gly Lys Lys Ala Asp Ile Lys Phe Asp Val Thr Arg Gln Leu Trp Ile 
                245                 250                 255     


Gln Asp Val Gln Ala Asn Lys Gln Leu Ile Leu Asp Lys Tyr Tyr Ser 
            260                 265                 270         


Asn Asn Val Cys Arg Tyr Tyr Lys Pro Glu Met Val Lys Lys Leu Ile 
        275                 280                 285             


Gly Asn Leu Tyr His Gly Tyr Val Glu Gln Glu Ala Gln Ile Pro Ala 
    290                 295                 300                 


Phe Arg Thr Val Trp Lys Arg Lys Asp Phe Ala Lys Tyr Leu Asn Asp 
305                 310                 315                 320 


Ser Asn Phe Leu Pro Val Asn Ile Lys Asn Asp Val Lys Glu Arg Thr 
                325                 330                 335     


Val Phe Glu Gly Ala Leu Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg 
            340                 345                 350         


Lys Tyr Thr Val Gly Gln Asp Ala Pro Lys Tyr Phe Phe Glu Ala Val 
        355                 360                 365             


Arg Ala Tyr Ser Asp Glu His Ala Lys Asn Lys Gln Asp Pro Tyr Ala 
    370                 375                 380                 


Asn Gln Ala Lys Asn Phe Trp Asp Tyr Val Glu Lys Leu Gln Lys Ser 
385                 390                 395                 400 


Tyr Glu Lys Gly Thr Leu Thr Phe Gly Ala Val Cys Gln Thr Ile Met 
                405                 410                 415     


Thr Glu Phe Val Gln Gln Asn Ser Lys Ala Thr Glu Lys Glu Gly Glu 
            420                 425                 430         


Ile Tyr Gln His Phe Lys Val Leu Phe Pro Leu Cys Met Gln Arg Gly 
        435                 440                 445             


Phe Glu Lys Tyr Val Lys Glu Lys His Gly Tyr Leu Leu Lys Pro Trp 
    450                 455                 460                 


Leu Asp Thr Val Val Arg Glu Asn Val Leu Gln Asp Ala Ala Ile Thr 
465                 470                 475                 480 


Cys Phe Asp Asp Leu Met Arg Asp Ala Glu Asp Arg Glu Tyr Ser Trp 
                485                 490                 495     


Tyr Val Val Ala His Phe Ile His Pro Lys Lys Leu Asn His Phe Val 
            500                 505                 510         


Gly Ala Leu Lys Asp Tyr Leu Gln Phe Lys Gln Asp Ile Phe Arg Arg 
        515                 520                 525             


Cys Ser Phe Ala Asn Ile Tyr Ser Glu Gly Glu Leu Ser Gln Lys Lys 
    530                 535                 540                 


Ala Met Leu Ala Glu Lys Glu Ala Glu Ile Ser Glu Ile Leu Arg Val 
545                 550                 555                 560 


Met Glu Phe Val Arg Gly Ile Thr Gly Arg Val Ser Lys Thr Phe Ser 
                565                 570                 575     


Asp Tyr Tyr Glu Asn Glu Glu Val Tyr Ala Asn Tyr Leu Gly Lys Tyr 
            580                 585                 590         


Ile Asp Phe Pro Lys Thr Asp Gly Ile Ser Val Phe Glu Ser Phe Arg 
        595                 600                 605             


Asp Phe Cys Thr Asn Thr Leu Pro Asp Gly Asn Val Leu Asp Val Tyr 
    610                 615                 620                 


Met Asp Glu Lys Asn Pro Arg Leu Leu Lys Asn Val Glu Leu Ala Arg 
625                 630                 635                 640 


Met Tyr Ala Gly Gly Asp Val Ala Leu Lys Lys Arg Lys Arg Ile Thr 
                645                 650                 655     


Ala Lys Asp Leu Gln Arg Tyr Tyr Gly Asn Glu Val Ala Val Gln Lys 
            660                 665                 670         


Ile Leu Gln Lys Gly Leu Cys Ser Thr Arg Glu Glu Gln Gln Arg Val 
        675                 680                 685             


Leu Glu Gln Gln Asn Leu Arg Gly Arg Ile Thr Leu Asn Asp Val Thr 
    690                 695                 700                 


Glu Ile Gln Glu Ile Ile Ser Asp Met Leu Ser Gln Leu Val Thr Phe 
705                 710                 715                 720 


Ser Tyr Phe Arg Glu Arg Asp Gln Met Tyr Leu Leu Leu Gly Phe Tyr 
                725                 730                 735     


Tyr Met Ala Leu Gln Thr Asn Arg Gly Ser Ser Trp Gly Asn Glu Thr 
            740                 745                 750         


Ile Asp Phe Cys Ala Gly Lys Lys Ile Ser Ile Lys Gln Gly Trp Val 
        755                 760                 765             


Leu His Gln Val Arg Ser Val Phe Thr Tyr Gly Leu Lys Leu Tyr Ser 
    770                 775                 780                 


Glu Leu Asp Glu Lys Gly Val Gly Gly Gln Leu Ser Ser Lys Ile Val 
785                 790                 795                 800 


Ala Phe Glu Arg Val His Arg Thr Ser Leu Ala Cys Ala Leu Arg Leu 
                805                 810                 815     


Phe Met Asp Glu Asn Cys Ser Arg Arg Ala Val Asp Val Arg Asn Tyr 
            820                 825                 830         


Val Asp His Phe Lys Tyr Tyr Phe Lys Ala Asp Arg Ser Ile Met Glu 
        835                 840                 845             


Leu Tyr Ser Ala Tyr Tyr Asp Cys Phe Phe Asp Tyr Ser Thr Lys Met 
    850                 855                 860                 


Arg Lys Ser Val Leu Leu Asn Phe Ile Ser Ile Leu Glu Arg His Phe 
865                 870                 875                 880 


Val Val Ser Lys Leu Arg Val Asn Cys Leu Glu Glu Arg Cys Ser Val 
                885                 890                 895     


Ser Phe Ala Glu Ser Leu Lys Ser Glu Lys Phe Thr Tyr Lys Leu Glu 
            900                 905                 910         


Ala Asp Ala Asn Lys Lys Ser Lys Glu Gln Thr Val Glu Phe Pro Ala 
        915                 920                 925             


Arg Asp Lys Glu Phe Leu Glu Ser Leu Gln Ala Glu Leu Glu Tyr Lys 
    930                 935                 940                 


Glu Gly Tyr Asn Ser 
945                 


<210>  914
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  914

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  915
<211>  1187
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  915

Met Lys Ile Ile Arg Pro Tyr Gly Ser Ser Ser Thr Asp Leu Asn Glu 
1               5                   10                  15      


Arg Ser Leu Ser Asp Lys Asn Glu Gln Lys Gln Glu Ile Thr Leu Tyr 
            20                  25                  30          


Cys Thr Glu His Glu Glu Leu Val Ile Ala Gln Trp Ile Ser Ile Ile 
        35                  40                  45              


Asp Lys Ile Ile Ile Lys Pro Lys Gln Asp Lys Ala Pro Ser Asp Glu 
    50                  55                  60                  


Gln Arg Ser Ala Arg Thr Lys Ile Gly Glu Ala Ala Trp Lys Leu Ile 
65                  70                  75                  80  


Ile Ala Asp Met Arg Leu Lys Thr Arg Asp Thr Ala Arg Leu Ala His 
                85                  90                  95      


Leu Ala Arg Leu Trp Asn Phe Lys Ile His Pro Tyr Gly Thr Lys Thr 
            100                 105                 110         


Gly Asn Gln Asn Ser Asn His Gly Arg Pro Leu Pro Ser Ile Lys Gly 
        115                 120                 125             


Arg Trp Tyr Lys Val Phe Val Gly Asp Asn Val Pro Val Glu Asp Ile 
    130                 135                 140                 


Asn Pro Gln Asp Thr Ala Gln Arg Ile Ser Glu His Leu Tyr Glu Ala 
145                 150                 155                 160 


Glu Tyr Arg Ile Lys Leu Gly His Pro Lys Arg Arg Lys Gly Leu Ile 
                165                 170                 175     


Gln Ala Arg Ala Glu Ser Ile Lys Lys Asn Val Pro Ser Lys Lys Gln 
            180                 185                 190         


Pro Ala Thr Gln Pro Thr Trp Ser Asp Gly Asp Ile Glu Arg Tyr Thr 
        195                 200                 205             


Lys His Gly Asp Val Ala Ala Ala Ile Trp Asn Lys Ala Thr Glu Cys 
    210                 215                 220                 


Glu Thr Asn Lys Lys Pro Val Arg Leu Asp Ile Ala Ala Ala Cys Leu 
225                 230                 235                 240 


Tyr Asp His Trp Ala Lys Ile Phe Phe Asp Pro Ala Thr Lys Ala Val 
                245                 250                 255     


Leu Asn Ile Thr Gln Ala Lys Asp Lys Glu Pro Asn Leu Tyr Ala Leu 
            260                 265                 270         


His Met Ala Ile Lys Arg Thr Tyr Thr Arg Ile Leu Lys Asn His Arg 
        275                 280                 285             


Lys Asn Thr Lys Asp Gln Gln Asn Lys Asn Ala Asn Asn Asn Arg Lys 
    290                 295                 300                 


Ile Ser Ser Ile Leu Pro Arg Asp Met Gln Glu Leu Leu Arg Met Ser 
305                 310                 315                 320 


Arg Asp Gln Lys Asp Asn Thr Asp Ile Ala Ser Leu Val Arg Leu Gly 
                325                 330                 335     


Lys Ile Ile His Tyr Thr Ala Ser Asp Asn Asp His Asp Asn Thr Lys 
            340                 345                 350         


Asn Ile Ile Ala Asn Trp Pro Gln Asp Val Ser Gln Ser Arg Phe Trp 
        355                 360                 365             


Thr Ser Asp Gly Gln Ala Glu Ile Lys Arg Ala Glu Ser Phe Val Arg 
    370                 375                 380                 


Val Trp Arg Arg Thr Leu Ser Tyr Ala Thr Leu Thr Leu Arg Asn Trp 
385                 390                 395                 400 


Ala Ser Ile Glu Ala Glu Asp Ala Glu Gln Asp Leu Leu Gly Ser Gly 
                405                 410                 415     


Asp Ala Ile Ala Gly Ala Ile Glu Lys Ile Lys His Asn Tyr Asp His 
            420                 425                 430         


Asp Thr Phe Lys Lys Lys Thr Glu Leu Leu Phe Gly Lys Arg Ala Ala 
        435                 440                 445             


Ser Leu Leu Ser Asp Lys Asp Lys Asn Thr Glu Leu Leu Asn Phe Ala 
    450                 455                 460                 


Leu Lys Gly Ala Arg Asp Leu Arg Asn Ala Ser Phe His Phe Lys Gly 
465                 470                 475                 480 


Leu Gly Met Phe Ile Lys Gln Leu Glu Ala Leu Glu Gln Asp Ser Arg 
                485                 490                 495     


Ala Lys Asp Leu Trp Glu Gln Asp Asn Ala Asp Tyr Ala Glu Ser Ile 
            500                 505                 510         


Arg Ala Lys Leu Lys Gly Ala His Ala Glu Phe Phe Phe Thr Gln Thr 
        515                 520                 525             


Gln Asn Glu Gln Leu Leu Thr Leu Leu Ala Lys Pro Asn Glu Asn Ala 
    530                 535                 540                 


Leu Pro Leu Pro Arg Phe Ser Arg Val Leu Leu Arg Ala Glu Asn Thr 
545                 550                 555                 560 


Arg Asp Thr Asn Asn Pro Cys Gln Leu Pro Ala Pro Thr Asn Arg Thr 
                565                 570                 575     


Glu Leu Glu Glu Asn Pro Ala Arg Leu Cys Gln Tyr Thr Ala Leu Lys 
            580                 585                 590         


Ser Val Tyr Glu Lys Asp Phe Arg Val Trp Leu Thr Glu Lys Lys Gly 
        595                 600                 605             


Asp Ala Leu His Asn Trp Ile Asp Ser Ala Ile Lys Arg Thr Thr Lys 
    610                 615                 620                 


Ala Ala Arg Thr Ile Asn Gly Lys Lys Asp Glu Asn Asn Arg Asp Leu 
625                 630                 635                 640 


Ile Ile Ser Lys Ala Ala Gly Leu Pro Lys Pro Lys Ala Glu Asp Gly 
                645                 650                 655     


Ile Ala Gln Phe Leu Phe Lys Leu Ser Ala Ala Thr Ala Ser Glu Met 
            660                 665                 670         


Arg Val Gln Arg Gly Tyr Glu Ser Asp Gly Glu Lys Ala Lys Glu Gln 
        675                 680                 685             


Ala Glu Tyr Ile Asp Glu Phe Leu Cys Asp Val Ile Ala Leu Ala Leu 
    690                 695                 700                 


Ala Asp Tyr Leu Lys Glu Lys Gly Leu Gln Trp Leu Ala Ala Leu Lys 
705                 710                 715                 720 


Pro Asp Gln Pro Lys Ala Tyr Gln Met Ser Tyr Leu Glu Lys Ile Pro 
                725                 730                 735     


Leu Pro Lys Leu Thr Asp Arg Ser Glu Glu Trp Gln Ala Thr Leu Tyr 
            740                 745                 750         


Leu Leu Leu His Met Ile Pro Val Glu Asp Ala Gly Lys Leu Leu His 
        755                 760                 765             


Gln Ile Lys Lys Trp Glu Ile Thr Ala Ser Arg Pro Thr Ala Ser Lys 
    770                 775                 780                 


Ser Lys Thr Leu Glu Ser Leu Thr Pro Leu Leu Arg Val Leu His Leu 
785                 790                 795                 800 


Tyr Leu Asp Met His Asp Ala Lys Phe Glu Gly Gly Met Ser Leu Ala 
                805                 810                 815     


Ser Cys Glu Lys Phe Ser Ala Phe Phe Glu Thr Gln Gly Gly Phe Asp 
            820                 825                 830         


Thr Ile Phe Pro Lys Asp Pro Ser Pro Asp Ala Gln Asp Arg Ile Pro 
        835                 840                 845             


Lys Arg Gly Leu Arg Glu Val Met Arg Phe Gly His Phe Pro Leu Leu 
    850                 855                 860                 


Gln Lys Ile Ser Thr Lys Lys Ile Thr Asn Glu Met Ile Glu Glu Met 
865                 870                 875                 880 


Leu Glu Gln Glu Lys Ile Ala Pro Ser Glu Lys Leu Ser Lys Ile Ala 
                885                 890                 895     


Lys Ala Gln His Gln Arg Glu Asp Ile His Lys Lys Trp Ala Lys Ala 
            900                 905                 910         


Pro Lys Asn Leu Ser Asn Asn Asp Lys Arg Ala Tyr Cys Glu Ala Leu 
        915                 920                 925             


Arg Ile Val Ile Asn His Arg Lys Asn Ala Ala Gln Val Asn Leu Val 
    930                 935                 940                 


Asn His Val Arg Ile His Arg Leu Leu Met Ser Val Leu Ala Arg Leu 
945                 950                 955                 960 


Leu Asp Tyr Ser Gly Leu Phe Glu Arg Asp Leu Tyr Phe Val Thr Leu 
                965                 970                 975     


Ala His Ile His Leu Ala Arg Lys Lys Thr Asp Asp Phe Ser Thr Asn 
            980                 985                 990         


Lys Glu Asn Arg Asp Lys Ile Arg  Asp Lys Leu Lys Asn  Gly Gln Ile 
        995                 1000                 1005             


Ile Glu  Ser Leu Asn Ile Val  Asn Gln Asn Glu Asp  Ala Lys Thr 
    1010                 1015                 1020             


Leu Cys  Glu Asn Ile Ala His  His Phe Gly Ser Val  Trp Glu Glu 
    1025                 1030                 1035             


Asn Asn  Asn Ile Gln Ile Ile  Arg Asn Asn Leu Ser  His Phe Asn 
    1040                 1045                 1050             


Met Leu  Glu Leu Asn Gln Pro  Ile Pro Asp Leu Thr  His Trp Val 
    1055                 1060                 1065             


Asn Gln  Thr Arg Lys Leu Val  Ala Tyr Asp Arg Lys  Leu Lys Asn 
    1070                 1075                 1080             


Ala Val  Ser Gln Ser Val Asn  Glu Leu Leu Gln Arg  Glu Gly Ile 
    1085                 1090                 1095             


Ile Ile  Asp Trp Val Met Asn  Lys Asp His Gln Leu  Glu Asn Pro 
    1100                 1105                 1110             


Ser Val  Thr Thr Ala Tyr Ala  Thr His Leu Lys Thr  Lys Ser Ile 
    1115                 1120                 1125             


Gln Glu  Ala Leu His Gly Glu  Asp Tyr Ile His Met  Val Val Ala 
    1130                 1135                 1140             


Leu Leu  Lys Gly His Ile Ser  Pro Lys Ile Thr Asp  Ile Thr Thr 
    1145                 1150                 1155             


Thr Ser  Ile Asp Glu Ile Leu  Arg Glu Asn Ala Pro  Lys Asn Lys 
    1160                 1165                 1170             


Asn Tyr  Gly Asn Lys Asn His  Arg Asn His Ala Lys  Arg Pro 
    1175                 1180                 1185         


<210>  916
<211>  978
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  916

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val 
        


<210>  917
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  917

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Gly Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  918
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  918

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Gly Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  919
<211>  1220
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  919

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Pro Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asp Leu Cys Lys Glu Glu Asn Arg Glu 
65                  70                  75                  80  


Trp Ile Val Glu Asp Leu Thr Lys Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Lys Asn Pro Lys Glu Lys Arg Glu Glu Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Asn Lys Asn Ser Ile Lys 
        115                 120                 125             


Ile Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Ser Ala Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Glu Ala Tyr Ile Arg Glu Met Ile Ser Asn Leu Val Leu Arg 
                165                 170                 175     


Lys Leu Lys Lys Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Cys 
            180                 185                 190         


Lys Met Gln Met Thr Glu Ile Thr Ile Ser Leu Met Ser Ala Ile Cys 
        195                 200                 205             


Leu Tyr Gly Asn Val Glu Ser Phe Asp Pro Val Ile Leu Lys Ala Phe 
    210                 215                 220                 


Phe Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln 
225                 230                 235                 240 


Ile Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu 
                245                 250                 255     


Lys Asp Gly Lys His Leu Leu Ile Pro Ala Asn Ala Asp His Arg Lys 
            260                 265                 270         


Lys Lys Tyr Val Phe Glu Phe Met Arg Lys Tyr Ala Ala Ala Glu Glu 
        275                 280                 285             


Lys Glu Lys Arg Glu Ile Thr Glu His Ile Gln Asn Leu Ile Gly Leu 
    290                 295                 300                 


Tyr Phe Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser 
305                 310                 315                 320 


Asn Met Thr Glu Ser His Asn Cys Ile Ser Gly Glu Ile Glu Glu Ile 
                325                 330                 335     


Phe Asn Glu Ile Glu Glu Leu Glu Asn Ser Ser Lys Gln Lys Arg Glu 
            340                 345                 350         


Glu Lys Lys Lys Thr Arg Glu Glu Leu Asp Lys Ile Gln Glu Ser Arg 
        355                 360                 365             


Lys Gly Asn Lys Arg Asn Thr Asn Ser Asn Asn Gln Asn Tyr Lys Asn 
    370                 375                 380                 


Asn Lys Thr Asp Ser Asp Lys Lys Glu Asn Gln Ala Asp Ala Asn Glu 
385                 390                 395                 400 


Asn Lys Leu Lys Glu Asn Glu Leu Arg Asp Lys Ile Arg Arg Leu Ser 
                405                 410                 415     


Lys Glu Leu Glu Asn Leu Asp Ser Glu Val Arg Ile Lys Lys Glu Lys 
            420                 425                 430         


Leu Lys Asn Thr Thr Val Lys Glu Met Ala Leu Lys Tyr Arg Ala Ala 
        435                 440                 445             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Arg Gly Glu Ile 
    450                 455                 460                 


Lys Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
465                 470                 475                 480 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                485                 490                 495     


Arg Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            500                 505                 510         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        515                 520                 525             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Ala Leu Glu Gly Glu Ser 
    530                 535                 540                 


Val Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
545                 550                 555                 560 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                565                 570                 575     


Glu Glu Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            580                 585                 590         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        595                 600                 605             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    610                 615                 620                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
625                 630                 635                 640 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                645                 650                 655     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            660                 665                 670         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        675                 680                 685             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Glu Leu Thr 
    690                 695                 700                 


Glu Tyr Phe Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
705                 710                 715                 720 


Glu Lys Tyr Tyr Thr Asn Asn Val Trp Lys Tyr Tyr Asp Ile Glu Val 
                725                 730                 735     


Ile Asn Asn Ile Met Gly Lys Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            740                 745                 750         


Ala Gln Val Pro Ala Phe Asn Asn Ile Ile Ser Arg Pro Ala Leu Pro 
        755                 760                 765             


Gln Leu Met Asp Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    770                 775                 780                 


Asn Cys Pro Asp Arg Asp Val Ile Lys Lys Tyr Trp Ser Ser Leu Phe 
785                 790                 795                 800 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Glu 
                805                 810                 815     


Lys Pro Glu Asp Asn Ile Lys Glu Arg Phe Phe Arg Ala Met Glu Lys 
            820                 825                 830         


Glu Ser Gly Gln Ala Lys Asp Gly Lys Glu Gln Lys Ala Trp Glu Ser 
        835                 840                 845             


Phe Glu Asn Arg Ile Asp Gln Ile Gly Arg Glu Arg Ser Phe Gly Ala 
    850                 855                 860                 


Ile Cys Gln Gly Leu Met Val Glu Tyr Met Leu Gln Asn Arg Asp Ile 
865                 870                 875                 880 


Ser Met Val Gln Thr Glu Thr Gly Asp Gly Lys Thr Asn Lys Lys Gln 
                885                 890                 895     


Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Ile Cys Ile Arg Ser Ala 
            900                 905                 910         


Phe Thr Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro Val 
        915                 920                 925             


Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Gln Thr Asp Gly 
    930                 935                 940                 


Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Glu Thr Phe Asn Asp 
945                 950                 955                 960 


Ala Glu Ser Gly Ser Phe Trp Tyr Met Ala Ala His Phe Ile Asn Gln 
                965                 970                 975     


Lys Tyr Leu Asn His Leu Ile Gly Ser Ile Arg Asn Tyr Leu Gln Phe 
            980                 985                 990         


Thr Glu Asp Ile Glu Asp Arg Ala  Leu Ser Leu Gly Asp  Cys Val Asp 
        995                 1000                 1005             


Asn Lys  Arg Glu Glu Lys Asn  Leu Arg Tyr Arg Asn  Thr Leu Glu 
    1010                 1015                 1020             


Ile Leu  Glu Phe Val Ala Gln  Phe Cys Glu Arg Thr  Thr Asn Val 
    1025                 1030                 1035             


Met Glu  Asp Tyr Phe Glu Ser  Asn Gln Glu Tyr Ala  Ala Tyr Leu 
    1040                 1045                 1050             


Ser Gly  Phe Val Asp Tyr Asn  Val Ser Lys Lys Glu  Thr Asp Ile 
    1055                 1060                 1065             


Glu Lys  Ala Leu Tyr Gly Phe  Cys Arg Gln Lys Phe  Lys Val Asp 
    1070                 1075                 1080             


Gly Lys  Glu Tyr Met Ala Gly  Ile Tyr Tyr Asp Gly  Glu Asn Leu 
    1085                 1090                 1095             


Ile Pro  Asn Arg Asn Ile Ile  Arg Ala Asn Met Tyr  Gly Asn Val 
    1100                 1105                 1110             


Ser Cys  Leu Lys Pro Tyr Met  Asp Arg Ile Thr Leu  Lys Glu Ile 
    1115                 1120                 1125             


Arg Thr  Met Tyr Ala Asp Gln  Asn Lys Leu Asp Ile  Val Leu Lys 
    1130                 1135                 1140             


Glu Gly  Val Cys Arg Thr Glu  Glu Glu Gln Lys Ala  Tyr Arg Glu 
    1145                 1150                 1155             


Tyr Gln  Asn Glu Lys Asn Arg  Ile Glu Leu Phe Asp  Leu Cys Thr 
    1160                 1165                 1170             


Tyr Thr  Gln Ile Leu Asn Asp  Met Gln Ala Lys Leu  Ile Gly Trp 
    1175                 1180                 1185             


Ser Tyr  Met Arg Glu Arg Asp  Leu Met Tyr Tyr Gln  Leu Gly Tyr 
    1190                 1195                 1200             


Tyr Tyr  Thr Lys Leu Phe Trp  Thr Asp Ala Ile Ser  Glu Glu Asp 
    1205                 1210                 1215             


Ala Arg  
    1220 


<210>  920
<211>  1380
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  920

Met Lys Leu Ser Lys Glu Lys Gln Ile Arg Ser Ala Val Ala Asn Lys 
1               5                   10                  15      


Glu Lys Asn Thr Glu Gly Val Leu Tyr Arg Phe Pro Gly Asp Asp Ile 
            20                  25                  30          


Gly Gly Val Gln Ala Gln Met Leu Val Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Leu Gly Asn Lys Pro Lys Glu 
    50                  55                  60                  


Trp Met Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Lys Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Ala Ile Asn Asp Ile Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Lys Glu Ala Asp Lys Lys Ile Arg Asn Met Ser Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Asn Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Ser Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Gly Asn Gln Glu Phe Asp Ser Ile Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Asp Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Ser Ile Gln Asp Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Ile Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Glu Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Asp Gly Leu Asn Glu Phe Met Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Glu Glu Lys Arg Ala Glu Val Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Ile His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Val Asn Lys Gly Lys Phe Tyr Val Trp 
305                 310                 315                 320 


Lys Lys His Glu Cys Gly Lys Lys Glu Asn Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Val Glu Ala Glu Ala Glu Ser Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Ile Phe Phe Glu Asn Asp Thr Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Thr Gly Thr Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Lys Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asn Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Gln Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Leu 
            660                 665                 670         


Val Arg Thr Val Phe Pro Glu Tyr Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Asn Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Arg Thr Leu Arg Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Lys 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Glu Asn Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Cys Ala Gln Asp 
            900                 905                 910         


Ile Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu 
        915                 920                 925             


Leu Ser Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Lys Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Lys Phe Ser Glu Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Thr Asn Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Gly  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Glu Lys Pro Glu  Glu Tyr Glu Lys Ile  Glu Ala Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Ile  Tyr Ala Pro Glu Lys  Asn Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Gln Gly Arg Val Gly  Ala Lys Val 
    1145                 1150                 1155             


Thr Ser  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Glu Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Met Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Val Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Val Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Glu Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asn Ala 
    1280                 1285                 1290             


Lys Asp  Lys Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Asp  Ala Glu Asp Ala Asp  Ser Lys Lys Pro Val  Ile Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Glu  Asp Glu Asp 
    1325                 1330                 1335             


Lys Gln  Lys Gly Lys Glu Asn  Arg Gly Lys Lys Asn  Thr Glu Thr 
    1340                 1345                 1350             


Arg Ser  Asp Ala Glu Lys Asn  Asn Asn Glu Arg Leu  Ser Tyr Asn 
    1355                 1360                 1365             


Pro Phe  Ala Asn Phe Asp Phe  Lys Leu Pro Asn Lys  
    1370                 1375                 1380 


<210>  921
<211>  1102
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  921

Met Arg Val Ser Lys Val Lys Val Asp Asn Lys Asn Met Val Leu Met 
1               5                   10                  15      


Arg Arg Thr Thr Gly Asn Gly Ala Leu Val Tyr Glu Gly Glu Thr Ser 
            20                  25                  30          


Asn Arg Thr Ile Glu Ile Leu Pro Lys Gln Lys Ile Gln Ser Phe Ser 
        35                  40                  45              


Leu Ser Ile Glu Asn Lys Thr Leu Ile Lys Arg Asp Ser Leu Lys Gly 
    50                  55                  60                  


Thr Val Gln Lys Asn Lys Tyr Asp Val Ile Arg Ala Ile Ile Lys Tyr 
65                  70                  75                  80  


Asn Arg Phe Pro Asp Arg Ile Ser Ala Glu Glu Val Leu Pro Phe Leu 
                85                  90                  95      


Asn His Lys Phe Gln Asn Glu Ile Lys Tyr Tyr Asn Asp Asn Lys Leu 
            100                 105                 110         


His Ser Phe Leu Leu Thr Ser Leu Ile Val Glu Ala Val Lys Glu Lys 
        115                 120                 125             


Asn Pro Gln Lys Leu Gln Pro Tyr Phe Asp Trp Glu Glu Trp Tyr Ile 
    130                 135                 140                 


Ser Asn Lys Ser Asn Ala Leu Ile Lys Ser Ile Glu Asn Asn Lys Ile 
145                 150                 155                 160 


Asp Ser Glu Lys Lys Asp Ser Lys Arg Lys Lys Thr Leu Gln Thr Trp 
                165                 170                 175     


Ala Ala Glu Tyr Thr Asp Asn Gly Ser Ile Asp Leu Ser Glu Tyr His 
            180                 185                 190         


Asn Ile Tyr Asp Ile Asp Thr Leu Val Arg Ala Leu Ile Lys Ala Asp 
        195                 200                 205             


Lys Gly Glu Leu Lys Glu Asp Gly Thr Pro Lys Asn Ala Asn Ala Phe 
    210                 215                 220                 


His Arg Asn Leu Lys Arg Thr Leu Gln Asp His Gln Lys Thr Val Phe 
225                 230                 235                 240 


Gly Thr Arg Glu Ala Ser Asn Met Thr Asn Arg Glu Asn Asp Gln Leu 
                245                 250                 255     


Ala Val Tyr His Leu Glu Val Val Lys Tyr Leu Glu His Tyr Phe Ser 
            260                 265                 270         


Val Lys Ser Thr Gln Arg Arg Asn Thr Arg Ala Asp Ile Asp Tyr Tyr 
        275                 280                 285             


Leu Lys Ala Glu Thr Ile Lys Asn Ile Ile Thr Lys Gln Leu Leu Asn 
    290                 295                 300                 


Ala Val Arg Asn Tyr Leu Leu Gln Gln Gly Lys Ala Gln His His Lys 
305                 310                 315                 320 


Phe Ala Glu Ile Lys Pro Asp Ser Asn Ser Leu Thr Glu Ile Lys Arg 
                325                 330                 335     


Asn Glu Ala Phe Val Leu Asn Met Ile Asp Ala Cys Gly Phe Ala Ala 
            340                 345                 350         


Asn Asn Ile Arg Asn Ile Val Asp Ala Glu Gln Ile Asn Asp Ile Leu 
        355                 360                 365             


Ser Lys Lys Glu Tyr Val Gln Ser Leu Asp Ser Asn Arg Val Asn Asn 
    370                 375                 380                 


Gln Leu Phe Lys Phe Phe Phe Gly Thr Asp Leu Pro Glu Thr Ala Thr 
385                 390                 395                 400 


Asp Lys Val Lys Thr Leu Trp Ala Met Arg Gly Ala Val Gln Gln Ile 
                405                 410                 415     


Arg Asn Lys Val Val His Tyr Lys Gln Lys Ala Leu Asp Ala Ile Phe 
            420                 425                 430         


Asn Val Thr Asp Phe Glu Tyr Pro Ser Phe Asn Asn Ser Ile Tyr Thr 
        435                 440                 445             


Asp Thr Ile Tyr Lys Asp Cys Leu Glu Thr Glu Leu Gln Lys Leu Pro 
    450                 455                 460                 


Glu Ala Phe Ala Gln Gln Leu Lys Thr Gly Gly Ala Leu Thr Tyr Tyr 
465                 470                 475                 480 


Pro Phe Asp Asp Leu Lys Thr Leu Leu Asn Lys Val Ala Phe Ser Leu 
                485                 490                 495     


Cys Arg Ser Val Val Pro Phe Ala Pro Gly Phe Lys Lys Val Gln Lys 
            500                 505                 510         


Gln Gly Gln Asn Tyr Gln Asn Ala His Lys Glu Asn Phe Tyr Asn Leu 
        515                 520                 525             


Asp Leu Lys Ser Tyr Leu Pro Lys Glu Lys Phe Asp Glu Glu Ala Tyr 
    530                 535                 540                 


Asn Ala Arg Tyr Phe Leu Leu Lys Leu Ile Tyr Asn Asn Leu Phe Leu 
545                 550                 555                 560 


Ser Asp Phe Thr Gly Asn Arg Glu Gln Phe Ser Ala Thr Val Asn Tyr 
                565                 570                 575     


Ile Leu Lys Arg Asn Lys Lys Gln Ala Glu Asn Ser Arg Arg Pro Lys 
            580                 585                 590         


Ala Tyr Ala Phe Glu Ala Val Arg Gln Met Lys Lys Glu Glu Ser Ile 
        595                 600                 605             


Thr Ser Tyr Met Ala Tyr Ala Gln Asn Gln Leu Met Val Glu Lys Asn 
    610                 615                 620                 


Lys Lys Glu Asp Asp Lys Pro Glu Asp Ile Arg Ile Asn Phe Glu Lys 
625                 630                 635                 640 


Phe Val Leu Gln Val Phe Ile Lys Gly Phe Asp Asp Phe Leu Leu Asn 
                645                 650                 655     


Glu Lys Phe Lys Phe Ile Ala Thr Pro Cys Phe Gln Leu Ser Lys Glu 
            660                 665                 670         


Asn Thr Lys Gln Gln Gln Ala Asp Val Leu Asn Gln Phe Glu Gln Arg 
        675                 680                 685             


Ile Ile Lys Glu Cys Arg Phe Gln Ser His Thr Ile Lys Ala Glu Glu 
    690                 695                 700                 


Ala Lys His Val Ala Phe Phe Thr Phe Cys Lys Leu Leu Asp Ala Thr 
705                 710                 715                 720 


His Leu Ser Asn Leu Arg Asn Glu Leu Ile Lys Phe Lys Gln Ser Ser 
                725                 730                 735     


Lys Gln Phe Glu Leu Cys His Val Leu Glu Ile Ile Glu Leu Ser Leu 
            740                 745                 750         


Leu Asn Ala Asp Val Val Pro Ala Asp Tyr Arg Glu Leu Tyr Ala Asn 
        755                 760                 765             


Lys Val Thr Cys Leu Asn Arg Val Arg Pro Phe Ile Ala Asp Gly Val 
    770                 775                 780                 


Asp Ile Thr Lys Trp Ser Gly Leu Phe Ile Gln Thr Asp Asn Glu Thr 
785                 790                 795                 800 


Pro Val Ile His Ala Asn Val Glu Leu Thr Val Lys Tyr Gly Thr Thr 
                805                 810                 815     


Lys Leu Leu Glu Gln Leu Ile Ala Lys Gly Ala Ser Phe Lys Leu Ser 
            820                 825                 830         


Glu Ser Asp Phe Asn Leu Trp Asn Ser Ala Lys Asp Thr Ile Lys Glu 
        835                 840                 845             


Val Ile Asn Lys Arg Leu Ser Leu His Lys Gln Trp Glu Asp Ala Ile 
    850                 855                 860                 


Arg Lys Asp Lys Glu Glu Lys Asn Lys Arg Val Lys Thr Arg Ser Asn 
865                 870                 875                 880 


Phe Ala Gln Gln Phe Ile Asn Lys Glu Arg Asp Ser Tyr Phe Asp Leu 
                885                 890                 895     


Cys Asp Tyr Ile Asp Ala Tyr Asn Trp Tyr Asp Ser Lys Leu His Phe 
            900                 905                 910         


Val Asn Leu Ile Arg Leu His His Leu Thr Ile Asp Ile Leu Gly Arg 
        915                 920                 925             


Met Val Gly Phe Val Ala Ile Trp Glu Arg Asp Phe Gln Tyr Met Thr 
    930                 935                 940                 


Glu Ser Ile Ser Pro Met Asn Ser Ser Lys Glu Leu Asp Phe Thr Lys 
945                 950                 955                 960 


Gly Phe Pro Leu Leu Lys Gly Ile Gln Leu Asp Tyr Tyr Lys Arg Ile 
                965                 970                 975     


Phe Leu Ser Gly Asn Tyr Arg Asp Ile Arg Asn Tyr Ile Ala His Phe 
            980                 985                 990         


Asn Tyr Leu Thr Asp Ser Lys Phe  Ser Met Ile Asp Leu  Ile Asn Glu 
        995                 1000                 1005             


Leu Arg  Glu Leu Leu Ser Tyr  Asp Arg Lys Leu Lys  Asn Ala Val 
    1010                 1015                 1020             


Asn Lys  Ala Phe Ile Asp Leu  Phe Asp Lys Gln Gly  Met Val Leu 
    1025                 1030                 1035             


Lys Leu  Lys Leu Asn Asp Ala  His Arg Phe Glu Ile  Glu Ser Val 
    1040                 1045                 1050             


Glu Pro  Lys Leu Leu Tyr His  Leu Gly Thr Thr Pro  Ala Arg Asp 
    1055                 1060                 1065             


Pro Ile  Ser Thr Tyr Gln Val  Lys Pro Gln Tyr Cys  Asp Met Cys 
    1070                 1075                 1080             


Lys Ala  Leu Leu Glu Ile Lys  Asn Ser Ser Arg Leu  Asn Asn Val 
    1085                 1090                 1095             


Ile Ile  Ser Leu 
    1100         


<210>  922
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  922

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Ile Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Leu Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Phe Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Phe Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Arg Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Lys Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Glu 
        755                 760                 765             


Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Ile Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1400                 1405                 1410         


<210>  923
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  923

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Pro Gly Thr Asp Thr 
            20                  25                  30          


Ile Gly Leu Lys Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Asp Lys Pro Lys Lys 
    50                  55                  60                  


Trp Lys Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Glu Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Ser Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Met Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Tyr Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ser Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Lys Asp Arg Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Lys Glu Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Gln Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Phe 
            660                 665                 670         


Ile Arg Lys Asn Phe Pro Glu Asp Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Asp Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Asp Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asn  Ser Glu Lys Lys Glu  Ala Tyr Gln Lys Ile  Glu Val Asn 
    1100                 1105                 1110             


Gly Asp  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Val  Tyr Ala Pro Asp Glu  Lys Gly Asp 
    1130                 1135                 1140             


Ile Leu  Lys Glu Gln Cys Thr  Lys Gly Gly Ala Gly  Gly Glu Ile 
    1145                 1150                 1155             


Ser Ala  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Lys Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Lys Gln 
    1250                 1255                 1260             


Thr Thr  Ser Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Ser Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Lys  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Val Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Gly Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Pro Asn 
    1370                 1375                 1380         


<210>  924
<211>  1248
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  924

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Thr Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Asp Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Ser Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val His Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Ile Asp Arg Lys  Ser Val Val 
    1235                 1240                 1245             


<210>  925
<211>  1185
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  925

Met Arg Ile Ile Lys Pro Tyr Gly Arg Ser Val Val Glu Lys Ala Gly 
1               5                   10                  15      


Pro Gly Arg Leu Ala Arg Ala Val Ser Leu His Pro Asp Pro Ala Arg 
            20                  25                  30          


Gly Val Glu Leu Asp Asn Arg Lys Ser Val Val Glu Phe Ala Ala Ser 
        35                  40                  45              


His Asp Arg Leu Val Ile Ala Gln Trp Ile Ser Thr Ile Asp Lys Ile 
    50                  55                  60                  


Ala Arg Lys Pro Val Gly Glu Ala Ala Ala Thr Pro Gln Gln Ala Glu 
65                  70                  75                  80  


Phe Arg Arg Arg Leu Gly Asp Ala Ala Trp Thr Leu Ile Glu Arg Arg 
                85                  90                  95      


Ala Leu Leu Thr Gly Leu Asn Asp Pro Ala Val Lys Ala Arg Leu Arg 
            100                 105                 110         


Arg Leu Trp Glu Phe Lys Ile Ala Pro Tyr Lys Thr Ala Arg Ala Val 
        115                 120                 125             


Ala Lys Thr Gly Thr Arg Pro Pro Arg Leu Lys Gly Trp Trp Phe Arg 
    130                 135                 140                 


Arg Phe Ala Gly Asp Val Glu Glu Val Asp Lys Val Asp Ala Asp Ala 
145                 150                 155                 160 


Val Ala Leu Ala Ile His Glu His Leu Tyr Ser Ala Gln Tyr Gln Met 
                165                 170                 175     


Arg Val Asp Asp Arg Thr Arg Leu Ser Gly Leu Ile Ala Ala Arg Ala 
            180                 185                 190         


Glu Ser Ile Ala Gly Asn Val Leu Gln Pro His Ala Ala Ala Arg Asp 
        195                 200                 205             


Lys Asp Gly Gly Trp Ser Glu Asp Asp Gln Arg Arg Tyr Ala Ala Ala 
    210                 215                 220                 


Gly Asp Val Ala Arg Glu Ile Arg Ser Ala Ala Glu Ala Arg Glu Arg 
225                 230                 235                 240 


Gly Asp Gly Lys Ile Gly Pro Arg Arg Val Thr Ser Glu Val Ala Gly 
                245                 250                 255     


Ala Ala Leu Phe Glu His Tyr Ala Arg Leu Phe Arg Gly Ala Asp Gly 
            260                 265                 270         


Lys Ala Met Gly Val Ala Gln Ala Arg Asp Gln Glu Ser Gly Leu Phe 
        275                 280                 285             


Asn Leu His Met Ala Val Lys Asp Cys Tyr Ala Arg Ile Leu Lys Gly 
    290                 295                 300                 


His Gly Lys Asp Leu Ala Lys His Gly Glu Gly Arg Arg Arg Val Ser 
305                 310                 315                 320 


Thr Leu Leu Pro Pro Thr Ser Val Asp Leu Phe Arg Leu Leu Asp Ala 
                325                 330                 335     


Met Leu Asp Asn Arg Asp Leu Asn Ala Leu Val Arg Leu Gly Lys Val 
            340                 345                 350         


Ile His Tyr Glu Ser Ala Gly Ala Gly Val Asp Arg Pro Ala Asp Val 
        355                 360                 365             


Val Asp His Trp Pro Ala Asp Val Ala Asp Ser Asp Tyr Trp Thr Ser 
    370                 375                 380                 


Asp Gly Gln Ala Arg Ile Lys Arg Asn Glu Ala Leu Val Arg Val Trp 
385                 390                 395                 400 


Arg His Val Leu Ala Leu Ala Ser Arg Thr Leu Thr Asp Trp Ala Asp 
                405                 410                 415     


Pro Lys Gly Met Ile Gly Gly Asp Ile Leu Leu Lys Asp Ser Val Glu 
            420                 425                 430         


Thr Ala Ile Ala Asn Phe Asp Ala Glu Ser Tyr Lys Arg Lys Ile Glu 
        435                 440                 445             


Val Leu Phe Gly Gly Arg Ala Ala Leu Phe Asp Gly Asp Gly Asp Glu 
    450                 455                 460                 


Ala Phe Glu Lys Asp Val Leu Arg Phe Ala Leu His Gly Val Ala Ala 
465                 470                 475                 480 


Leu Arg Asn Ala Ala Phe His Phe Lys Gly Val Gly Gly Phe Ala Glu 
                485                 490                 495     


Ala Leu Lys Thr Leu Gly Pro Arg Gln Asp Pro Arg Val Thr Ala Ala 
            500                 505                 510         


Val Asp Gly Leu Trp Arg Thr Asp Glu Glu Gly Arg Gly Arg Arg Leu 
        515                 520                 525             


Leu Ala Thr Met Arg Gly Ala His Phe Glu Ser Phe Phe Asp Gln Arg 
    530                 535                 540                 


Gln Asn Arg Arg Leu Ala Gln Ala Leu Ser Arg Ala Ser Glu Glu Ser 
545                 550                 555                 560 


Leu Pro Leu Pro Arg Phe Ala Val Met Leu Arg Arg Ala Glu Asn Ala 
                565                 570                 575     


Trp Asp Arg Leu Gly Leu Pro Lys Thr Ala Asn Arg Ala Asp Leu Glu 
            580                 585                 590         


Ala Pro Ala Arg His Cys Gln Tyr Val Ala Leu Lys Leu Leu Tyr Glu 
        595                 600                 605             


Arg Pro Phe Arg Ala Trp Leu Ala Glu Arg Asp Ala Ala Thr Leu Asn 
    610                 615                 620                 


Arg Phe Ile Val Cys Ala Val Glu Arg Ala Thr Lys Ala Ala Arg Met 
625                 630                 635                 640 


Leu Asn Pro Gly Ala Ser Arg Glu Leu Ala Glu Ala Ile Thr Ala Lys 
                645                 650                 655     


Ala Ala Asp Leu Gly Arg Leu Gly Asn Asp Asp Ser Val Glu Asp Phe 
            660                 665                 670         


Phe Phe Arg Leu Ser Ala Glu Thr Ala Gly Glu Ala Arg Val Gln Arg 
        675                 680                 685             


Gly Tyr Glu Ser Asp Ala Glu Asn Ala Arg Ala Gln Ala Ser His Ile 
    690                 695                 700                 


Glu Asn Leu Lys Ala Asp Leu Val Ala Leu Ala Phe Arg Asp Tyr Leu 
705                 710                 715                 720 


Gln Lys Ala Asp Phe Glu Phe Ala Leu Lys Leu Arg Gly Asp Glu Pro 
                725                 730                 735     


Leu Pro Thr Lys Pro Met Cys Ala Leu Asp Glu Ala Asp Phe Val Glu 
            740                 745                 750         


Gly Glu Ala Ser Ser Ala Glu Pro Pro Cys Glu Leu Tyr Phe Leu Leu 
        755                 760                 765             


His Leu Val Pro Val Asp Glu Val Gly Lys Leu Leu His Gln Leu Arg 
    770                 775                 780                 


Lys Trp Gln Ile Leu Ala Pro Pro Ala Pro Ala Ala Thr Gly Gly Pro 
785                 790                 795                 800 


Thr Thr Ala Ala Thr Val Ala Glu Ile Arg Leu Ala Leu Glu Leu Tyr 
                805                 810                 815     


Leu Asp Met His Asp Ala Lys Phe Glu Gly Gly Ala Ala Leu Val Gly 
            820                 825                 830         


Val Glu Pro Phe Lys Arg Leu Phe Glu Gly Asp Gly Leu Phe Gly Arg 
        835                 840                 845             


Ile Phe Glu Arg Pro Ala Gly Asp Arg Pro Gly Ala Glu Asp Asp Arg 
    850                 855                 860                 


Arg Leu Pro Arg Arg Gly Leu Arg Glu Ile Met Arg Phe Gly His Leu 
865                 870                 875                 880 


Arg Pro Leu Leu Pro Ile Phe Asp Lys Gln Pro Ile Arg Ala Asp Glu 
                885                 890                 895     


Val Ala Ala Tyr Leu Asp Ala Glu Gln Val Pro Asp Gly Gly Lys Ser 
            900                 905                 910         


Glu Ile Ala Arg Arg Gln Glu Arg Arg Glu Ala Leu His Glu Lys Trp 
        915                 920                 925             


Ala Arg Arg Arg Arg Glu Phe Ser Asp Asp Asp Arg Arg Ala Tyr Glu 
    930                 935                 940                 


Glu Ala Leu Arg Phe Val Glu Glu His Arg His Arg Ala Ala Arg Val 
945                 950                 955                 960 


Thr Leu Thr Asp His Val Arg Leu His Arg Leu Leu Met Ala Val Leu 
                965                 970                 975     


Gly Arg Leu Val Asp Tyr Ser Gly Leu Trp Glu Arg Asp Leu Tyr Phe 
            980                 985                 990         


Val Ala Leu Ala Leu Ile His Gln  Ala Gly Arg Arg Leu  Asp Glu Ile 
        995                 1000                 1005             


Phe Ala  Ala Asp Gly Leu Ala  Met Leu Arg Glu Gly  Arg Val Val 
    1010                 1015                 1020             


Glu Ala  Leu Arg Lys Leu Ala  Asp Ile Asp Ala Ala  Arg Ala Ile 
    1025                 1030                 1035             


Ala Ala  Glu Val Lys Arg Arg  Phe Asp Gly Ala Pro  Asp Ala Ala 
    1040                 1045                 1050             


Ser Arg  Val Val Lys Ile Arg  Asn Ala Phe Ala His  Phe Asn Met 
    1055                 1060                 1065             


Leu Arg  Pro Lys Arg Gly Gly  Ala Thr Ala Ala Leu  Asp Leu Thr 
    1070                 1075                 1080             


Ala Ala  Val Asn Asp Gly Arg  Glu Leu Met Ala Tyr  Asp Arg Lys 
    1085                 1090                 1095             


Leu Lys  Asn Ala Val Ser Arg  Ser Ile Ala Glu Leu  Leu Glu Arg 
    1100                 1105                 1110             


Glu Gly  Leu Ala Val Ala Trp  Ser Val Asn Glu His  Arg Leu Glu 
    1115                 1120                 1125             


Ala Thr  Arg Val Ser Thr Arg  Gln Ala Ser His Leu  Ala Asn Ser 
    1130                 1135                 1140             


Gly Leu  Arg Glu Asp Leu His  Gly Ala Gly Tyr Val  Ala Thr Val 
    1145                 1150                 1155             


Ala Glu  Leu Phe Gly Arg Thr  Ala Ala Lys Pro Ala  Ala Pro Leu 
    1160                 1165                 1170             


Ala Arg  Arg Glu Asn Arg Thr  Ala Arg Gly Gly Arg  
    1175                 1180                 1185 


<210>  926
<211>  1167
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  926

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Gly Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn 
    1160                 1165         


<210>  927
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  927

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Thr Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  928
<211>  1380
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  928

Met Lys Leu Ser Lys Glu Lys Gln Ile Arg Ser Ala Val Ala Asn Lys 
1               5                   10                  15      


Glu Lys Asn Thr Glu Gly Val Leu Tyr Arg Phe Pro Gly Asp Asp Ile 
            20                  25                  30          


Gly Gly Val Gln Ala Gln Met Leu Val Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Leu Gly Asn Lys Pro Lys Glu 
    50                  55                  60                  


Trp Met Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Lys Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Ala Ile Asn Asp Ile Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Lys Glu Ala Asp Lys Lys Ile Arg Asn Met Ser Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Asn Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Ser Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Gly Asn Gln Glu Phe Asp Ser Ile Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Asp Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Ser Ile Gln Asp Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Ile Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Glu Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Asp Gly Leu Asn Glu Phe Met Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Glu Glu Lys Arg Ala Glu Val Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Ser His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Val Asn Lys Gly Lys Phe Tyr Val Trp 
305                 310                 315                 320 


Lys Lys His Glu Cys Gly Lys Lys Glu Asn Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Val Glu Ala Glu Ala Glu Ser Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Ile Phe Phe Glu Asn Asp Thr Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Thr Gly Thr Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Lys Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asn Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Gln Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Leu 
            660                 665                 670         


Val Arg Thr Val Phe Pro Glu Tyr Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Asn Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Arg Thr Leu Arg Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Lys 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Glu Asn Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Cys Ala Gln Asp 
            900                 905                 910         


Ile Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu 
        915                 920                 925             


Leu Ser Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Lys Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Lys Phe Ser Glu Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Thr Asn Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Gly  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Glu Lys Pro Glu  Glu Tyr Glu Lys Ile  Glu Ala Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Ile  Tyr Ala Pro Glu Lys  Asn Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Gln Gly Arg Val Gly  Ala Lys Val 
    1145                 1150                 1155             


Thr Ser  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Glu Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Met Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Val Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Val Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Glu Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asn Ala 
    1280                 1285                 1290             


Lys Asp  Lys Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Asp  Ala Glu Asp Ala Asp  Ser Lys Lys Pro Val  Ile Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Glu  Asp Glu Asp 
    1325                 1330                 1335             


Lys Gln  Lys Gly Lys Glu Asn  Arg Gly Lys Lys Asn  Thr Glu Thr 
    1340                 1345                 1350             


Arg Ser  Asp Ala Glu Lys Asn  Asn Asn Glu Arg Leu  Ser Tyr Asn 
    1355                 1360                 1365             


Pro Phe  Ala Asn Phe Asp Phe  Lys Leu Pro Asn Lys  
    1370                 1375                 1380 


<210>  929
<211>  1102
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  929

Met Arg Val Ser Lys Val Lys Val Asp Asn Lys Asn Met Val Leu Met 
1               5                   10                  15      


Arg Arg Thr Thr Gly Asn Gly Ala Leu Val Tyr Glu Gly Glu Thr Ser 
            20                  25                  30          


Asn Arg Thr Ile Glu Ile Leu Pro Lys Gln Lys Ile Gln Ser Phe Ser 
        35                  40                  45              


Leu Ser Ile Glu Asn Lys Thr Leu Ile Lys Arg Asp Ser Leu Lys Gly 
    50                  55                  60                  


Thr Val Gln Lys Asn Lys Tyr Asp Val Ile Arg Ala Ile Ile Lys Tyr 
65                  70                  75                  80  


Asn Arg Phe Pro Asp Arg Ile Ser Ala Glu Glu Val Leu Pro Phe Leu 
                85                  90                  95      


Asn His Lys Phe Gln Asn Glu Ile Lys Tyr Tyr Asn Asp Asn Lys Leu 
            100                 105                 110         


His Ser Phe Leu Leu Thr Ser Leu Ile Val Glu Ala Val Lys Glu Lys 
        115                 120                 125             


Asn Pro Gln Lys Leu Gln Pro Tyr Phe Asp Trp Glu Glu Trp Tyr Ile 
    130                 135                 140                 


Ser Asn Lys Ser Asn Ala Leu Ile Lys Ser Ile Glu Asn Asn Lys Ile 
145                 150                 155                 160 


Asp Ser Glu Lys Lys Asp Ser Lys Arg Lys Lys Thr Leu Gln Thr Trp 
                165                 170                 175     


Ala Ala Glu Tyr Thr Asp Asn Gly Ser Ile Asp Leu Ser Glu Tyr His 
            180                 185                 190         


Asn Ile Tyr Asp Ile Asp Thr Leu Val Arg Ala Leu Ile Lys Ala Asp 
        195                 200                 205             


Lys Gly Glu Leu Lys Glu Asp Gly Thr Pro Lys Asn Ala Asn Ala Phe 
    210                 215                 220                 


His Arg Asn Leu Lys Arg Thr Leu Gln Asp His Gln Lys Thr Val Phe 
225                 230                 235                 240 


Gly Thr Arg Glu Ala Ser Asn Met Thr Asn Arg Glu Asn Asp Gln Leu 
                245                 250                 255     


Ala Val Tyr His Leu Glu Val Val Lys Tyr Leu Glu His Tyr Phe Ser 
            260                 265                 270         


Val Lys Ser Thr Gln Arg Arg Asn Thr Arg Ala Asp Ile Asp Tyr Tyr 
        275                 280                 285             


Leu Lys Ala Glu Thr Ile Lys Asn Ile Ile Thr Lys Gln Leu Leu Asn 
    290                 295                 300                 


Ala Val Arg Asn Tyr Leu Leu Gln Gln Gly Lys Ala Gln His His Lys 
305                 310                 315                 320 


Phe Ala Glu Ile Lys Pro Asp Ser Asn Ser Leu Thr Glu Ile Lys Arg 
                325                 330                 335     


Asn Glu Ala Phe Val Leu Asn Met Ile Asp Ala Cys Gly Phe Ala Ala 
            340                 345                 350         


Asn Asn Ile Arg Asn Ile Val Asp Ala Glu Gln Ile Asn Asp Ile Leu 
        355                 360                 365             


Ser Lys Lys Glu Tyr Val Gln Ser Leu Asp Ser Asn Arg Val Asn Asn 
    370                 375                 380                 


Gln Leu Phe Lys Phe Phe Phe Gly Thr Asp Leu Pro Glu Thr Ala Thr 
385                 390                 395                 400 


Asp Lys Val Lys Thr Leu Trp Ala Met Arg Gly Ala Val Gln Gln Ile 
                405                 410                 415     


Arg Asn Lys Val Val His Tyr Lys Gln Lys Ala Leu Asp Ala Ile Phe 
            420                 425                 430         


Asn Val Thr Asp Phe Glu Tyr Pro Ser Phe Asn Asn Ser Ile Tyr Thr 
        435                 440                 445             


Asp Thr Ile Tyr Lys Asp Cys Leu Glu Thr Glu Leu Gln Lys Leu Pro 
    450                 455                 460                 


Glu Ala Phe Ala Gln Gln Leu Lys Thr Gly Gly Ala Leu Thr Tyr Tyr 
465                 470                 475                 480 


Pro Phe Asp Asp Leu Lys Thr Leu Leu Asn Lys Val Ala Phe Ser Leu 
                485                 490                 495     


Cys Arg Ser Val Val Pro Phe Ala Pro Gly Phe Lys Lys Val Gln Lys 
            500                 505                 510         


Gln Gly Gln Asn Tyr Gln Asn Ala His Lys Glu Asn Phe Tyr Asn Leu 
        515                 520                 525             


Asp Leu Lys Ser Tyr Leu Pro Lys Glu Lys Phe Asp Glu Glu Ala Tyr 
    530                 535                 540                 


Asn Ala Arg Tyr Phe Leu Leu Lys Leu Ile Tyr Asn Asn Leu Phe Leu 
545                 550                 555                 560 


Ser Asp Phe Thr Gly Asn Arg Glu Gln Phe Ser Ala Thr Val Asn Tyr 
                565                 570                 575     


Ile Leu Lys Arg Asn Lys Lys Gln Ala Glu Asn Ser Arg Arg Pro Lys 
            580                 585                 590         


Ala Tyr Ala Phe Glu Ala Val Arg Gln Met Lys Lys Glu Glu Ser Ile 
        595                 600                 605             


Thr Ser Tyr Met Ala Tyr Ala Gln Asn Gln Leu Met Val Glu Lys Asn 
    610                 615                 620                 


Lys Lys Glu Asp Asp Lys Pro Glu Asp Ile Arg Ile Asn Phe Glu Lys 
625                 630                 635                 640 


Phe Val Leu Gln Val Phe Ile Lys Gly Phe Asp Asp Phe Leu Leu Asn 
                645                 650                 655     


Glu Lys Phe Lys Phe Ile Ala Thr Pro Cys Phe Gln Leu Ser Lys Glu 
            660                 665                 670         


Asn Thr Lys Gln Gln Gln Ala Asp Val Leu Asn Gln Phe Glu Gln Arg 
        675                 680                 685             


Ile Ile Lys Glu Cys Arg Phe Gln Ser His Thr Ile Lys Ala Glu Glu 
    690                 695                 700                 


Ala Lys His Val Ala Phe Phe Thr Phe Cys Lys Leu Leu Asp Ala Thr 
705                 710                 715                 720 


His Leu Ser Asn Leu Arg Asn Glu Leu Ile Lys Phe Lys Gln Ser Ser 
                725                 730                 735     


Lys Gln Phe Glu Leu Cys His Val Leu Glu Ile Ile Glu Leu Ser Leu 
            740                 745                 750         


Leu Asn Ala Asp Val Val Pro Ala Asp Tyr Arg Glu Leu Tyr Ala Asn 
        755                 760                 765             


Lys Val Thr Cys Leu Asn Arg Val Arg Pro Phe Ile Ala Asp Gly Val 
    770                 775                 780                 


Asp Ile Thr Lys Trp Ser Gly Leu Phe Ile Gln Thr Asp Asn Glu Thr 
785                 790                 795                 800 


Pro Val Ile His Ala Asn Val Glu Leu Thr Val Lys Tyr Gly Thr Thr 
                805                 810                 815     


Lys Leu Leu Glu Gln Leu Ile Ala Lys Gly Ala Ser Phe Lys Leu Ser 
            820                 825                 830         


Glu Ser Asp Phe Asn Leu Trp Asn Ser Ala Lys Asp Thr Ile Lys Glu 
        835                 840                 845             


Val Ile Asn Lys Arg Leu Ser Leu His Lys Gln Trp Glu Asp Ala Ile 
    850                 855                 860                 


Arg Lys Asp Lys Glu Glu Lys Asn Lys Arg Val Lys Thr Arg Ser Asn 
865                 870                 875                 880 


Phe Ala Gln Gln Phe Ile Asn Lys Glu Arg Asp Ser Tyr Phe Asp Leu 
                885                 890                 895     


Cys Asp Tyr Ile Asp Ala Tyr Asn Trp Tyr Asp Ser Lys Leu His Phe 
            900                 905                 910         


Val Asn Leu Ile Arg Leu His His Leu Thr Ile Asp Ile Leu Gly Arg 
        915                 920                 925             


Met Val Gly Phe Val Ala Ile Trp Glu Arg Asp Phe Gln Tyr Met Thr 
    930                 935                 940                 


Glu Ser Ile Ser Pro Met Asn Ser Ser Lys Glu Leu Asp Phe Thr Lys 
945                 950                 955                 960 


Gly Phe Pro Leu Leu Lys Gly Ile Gln Leu Asp Tyr Tyr Lys Arg Ile 
                965                 970                 975     


Phe Leu Ser Gly Asn Tyr Arg Asp Ile Arg Asn Tyr Ile Ala His Phe 
            980                 985                 990         


Asn Tyr Leu Thr Asp Ser Lys Phe  Ser Met Ile Asp Leu  Ile Asn Glu 
        995                 1000                 1005             


Leu Arg  Glu Leu Leu Ser Tyr  Asp Arg Lys Leu Lys  Asn Ala Val 
    1010                 1015                 1020             


Asn Lys  Ala Phe Ile Asp Leu  Phe Asp Lys Gln Gly  Met Val Leu 
    1025                 1030                 1035             


Lys Leu  Lys Leu Asn Asp Ala  His Arg Phe Glu Ile  Glu Ser Val 
    1040                 1045                 1050             


Glu Pro  Lys Leu Leu Tyr His  Leu Gly Thr Thr Pro  Ala Arg Asp 
    1055                 1060                 1065             


Pro Ile  Ser Thr Tyr Gln Val  Lys Pro Gln Tyr Cys  Asp Met Cys 
    1070                 1075                 1080             


Lys Ala  Leu Leu Glu Ile Lys  Asn Ser Ser Arg Leu  Asn Asn Val 
    1085                 1090                 1095             


Ile Ile  Ser Leu 
    1100         


<210>  930
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  930

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  931
<211>  1169
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  931

Met Lys Ile Thr Lys Arg Lys Trp Glu Asp Val Pro Pro Leu Phe Phe 
1               5                   10                  15      


His Arg Asp Lys Asp Ser Gly Arg Leu Ile Arg Gln Asp Asp Arg Glu 
            20                  25                  30          


His Asp Tyr Thr Asp Glu Leu Phe Arg Lys Thr Thr Val Asp Ser Ile 
        35                  40                  45              


Phe Ile Arg Ser Leu Gln Asn Arg Leu Leu Arg Ser Gln Asp Lys Glu 
    50                  55                  60                  


Gly Asn Lys Ile Gly Arg Asn Glu Ile Thr Glu Leu Val Glu Asn Leu 
65                  70                  75                  80  


Cys Lys Gly Ala Glu Ile Gln Lys Ser Ile Asp Glu Ile Lys Asp Ser 
                85                  90                  95      


Lys Ser Asn Val Lys Ala Leu Cys Asp Lys Thr Leu Thr Asp Tyr Gly 
            100                 105                 110         


Lys Ser Phe Ala Ala Glu Glu Gly Arg Thr Thr Leu Tyr Glu Ala Ile 
        115                 120                 125             


Leu Asn Leu Ala Lys Gly Asn Ala Ile Gln Lys Ala Met Ala Glu Ala 
    130                 135                 140                 


Glu Leu Lys Gln Ile His Glu Ala Leu Lys Lys Glu Lys Glu Asp Arg 
145                 150                 155                 160 


Ile Asn Arg Val Gln Asn Ser Ile Lys Asn Asn Lys Ile Pro Leu Lys 
                165                 170                 175     


Val Asn Glu Asp Gly Thr Ile Ser Ala Asn Asn Asp Arg Ala Ser Trp 
            180                 185                 190         


Leu Leu Glu Leu Leu Lys Pro Val Ala Ser Glu His Asp Lys Gly Asp 
        195                 200                 205             


Arg Tyr Pro Val Leu Thr Glu Met Glu Gly Ile Val Ser Phe Asp Lys 
    210                 215                 220                 


Leu Cys Glu Glu Val Arg Asn Lys Ile His Gly Arg Lys Gly Arg Thr 
225                 230                 235                 240 


Arg Ser Ile Ala Met Ser Val Asp Glu Ala Val Lys Glu Tyr Leu Lys 
                245                 250                 255     


Glu Leu Trp Lys Lys His Ala Asp Arg His Arg Asp Met Arg Tyr Tyr 
            260                 265                 270         


Phe Gln Ala Val Lys Glu Tyr Phe Lys Glu Asn Phe Pro Ile Arg Thr 
        275                 280                 285             


Lys Gln Lys Gly Ala Gly Ile Arg Gln Ser Leu Leu Lys Glu Asp Thr 
    290                 295                 300                 


Val Val Ala Arg Leu Leu Asp Pro Lys His Met Ala Lys Ala Val Arg 
305                 310                 315                 320 


Arg Lys Leu Ile Asn Gln Ser Thr Gln Met His Ile Leu Tyr Gly Lys 
                325                 330                 335     


Leu Tyr Glu Tyr Cys Cys Arg Glu Asp Arg Asn Leu Pro Val Asn Ser 
            340                 345                 350         


Glu Thr Leu Gln Leu Ile Gln Val Leu Glu Ala Val Lys Lys Gln Leu 
        355                 360                 365             


Met Thr Ala Val Leu Trp Ser Val Ser Arg Leu Cys Tyr Phe Tyr Glu 
    370                 375                 380                 


Phe Tyr Ser Gly Asp Ile Leu Leu Ala Glu Glu Tyr Arg Arg Asp Phe 
385                 390                 395                 400 


Leu Asn Gln Lys Asn Asp His Lys Asp Ile Gln Ala Cys Lys Glu Lys 
                405                 410                 415     


Leu Gln Asp Phe Phe Pro Leu Ala Glu Leu Gln Glu Lys Ile Arg Glu 
            420                 425                 430         


Cys Ala Asp Lys Asp Ile Asn Asn Ile Lys Asp Lys Ile Thr Asn Asp 
        435                 440                 445             


Val Leu Ala Cys Asn Asn Leu Leu Glu Glu Cys Val Phe Cys Ile Ser 
    450                 455                 460                 


Lys Leu Arg Asn Asn Ile Phe His Tyr Lys Asn Leu Ser Phe Thr Gln 
465                 470                 475                 480 


Ala Leu Lys His Ile Ala Asn Glu Ile Lys Glu Glu Asp Ile Pro Ile 
                485                 490                 495     


Ile Leu Arg Leu Tyr Lys Gln Asp Cys Glu Asn Val Asn Lys Ala Phe 
            500                 505                 510         


Ala Asn Arg Ile Ser Ser Met Asn Leu Pro Leu Tyr Tyr Ser Thr Glu 
        515                 520                 525             


Phe Leu Leu Arg Ile Phe Lys Lys Gln Gly Ala Glu Leu Ser Leu Tyr 
    530                 535                 540                 


Ser Thr Lys Asn Gln Met Thr Pro Ser Phe Lys Arg Val Tyr Glu Arg 
545                 550                 555                 560 


Gly Lys Asn Leu Arg Leu Glu Tyr Glu Arg Glu Pro Met Arg Ser Asn 
                565                 570                 575     


Ile Ala Asn Glu Tyr Asp Lys Asp Pro Gln Ser Asp Tyr Trp Met Arg 
            580                 585                 590         


Trp Phe Ser Gln Phe Ala Thr Gly Thr Val Asp Thr Asn Ala Gly Ile 
        595                 600                 605             


Lys Gly Glu Met Glu Asp Tyr Pro His Ala Ser Val Asn Leu Gly Ile 
    610                 615                 620                 


Glu Ile Glu Ala Gly Thr Asn Ile Asp Ala Gln Arg Ala Met Arg Asn 
625                 630                 635                 640 


Leu Leu Gln Leu Ile Tyr Lys His His Phe Leu Pro Glu Val Gln Lys 
                645                 650                 655     


Asp Glu Thr Val Val Thr Asp Val Ile Pro Lys Val Leu Glu Arg Asn 
            660                 665                 670         


Arg Lys Leu Ser Glu Val Arg Asn Arg Ser Asp Lys Thr Tyr Gly Tyr 
        675                 680                 685             


Lys Glu Ile Glu Glu Leu Cys Lys Lys Asn Lys Gly Lys Lys Asp Ser 
    690                 695                 700                 


Leu Ser Glu Leu Met Lys Asp Leu Gln Arg Lys Val Ser Glu Thr Glu 
705                 710                 715                 720 


Lys Glu Lys Arg Glu Leu Ala Arg Glu Lys Thr Asp Tyr Ala Gln Arg 
                725                 730                 735     


Phe Ile Leu Asp Ile Phe Ala Glu Ala Phe Cys Asn Phe Met Asp Glu 
            740                 745                 750         


Arg Tyr Glu Asp Glu Tyr Gln Glu Ile Met Ser Pro Ile Lys Asn Glu 
        755                 760                 765             


Glu Glu Ala Lys Lys Trp Thr Glu Met Phe Thr Asp Lys Ala Asp Lys 
    770                 775                 780                 


Asp Asn Lys Asp Lys Leu Leu Val Leu Lys Thr Ser Phe Asp Lys Asp 
785                 790                 795                 800 


Asn Val Glu Lys Tyr Leu Leu Val Leu Tyr Pro Leu Met Arg Leu Leu 
                805                 810                 815     


Asp Asp Lys Glu Leu Ser Glu Leu Gln Gln Gln Met Leu Arg Phe Arg 
            820                 825                 830         


Ala Ser Val Ser Gly Trp Gln Gly Gly Thr Asp Phe Ser Glu Asp Ile 
        835                 840                 845             


Ala Met Ala Glu Lys Ile Glu Glu Leu Ala Glu Leu Val Lys Leu Thr 
    850                 855                 860                 


Glu Pro Glu Ser Gln Tyr Ala Glu Glu Ala Trp Lys Asn Arg Ala Ile 
865                 870                 875                 880 


Gly Val Phe Glu Gln Phe Val Glu Gly Lys Met Ala Glu Tyr Gly Thr 
                885                 890                 895     


Phe Tyr Ile Gln Asn Asp Ser Leu Thr Gln Val Pro Arg Gly Asn Met 
            900                 905                 910         


Arg Lys Leu Leu Arg Ser Gly Val Ile Gly Val Tyr Asn Lys Val Leu 
        915                 920                 925             


Ala Ser Cys Lys Gln Ala Thr Lys Ala Asp Tyr Gly Ala Tyr Ser Gly 
    930                 935                 940                 


Asp His Trp Ser Ile Glu Asp Pro Asp Gly Asn Pro Ile Lys Ser Ala 
945                 950                 955                 960 


Glu Gln Ala Gln Ala Leu Leu Gln Arg Leu His Lys Lys Tyr Thr Glu 
                965                 970                 975     


Ser Pro Ser Gln Phe Ser Asp Asp Asp His Lys Leu Tyr Asp Lys Thr 
            980                 985                 990         


Leu Arg Gln Leu Asp Ala Tyr Asn  Arg Ala Met Lys Asn  Leu Ser Phe 
        995                 1000                 1005             


Gly Ser  Leu Tyr Glu Ile Cys  Arg Ile His Met Glu  Thr Leu Ser 
    1010                 1015                 1020             


Arg Trp  Val Gly Phe Val Gln  Asp Trp Glu Arg Asp  Met Tyr Phe 
    1025                 1030                 1035             


Leu Leu  Leu Ala Trp Thr Lys  Gln Gly Lys Leu Leu  Asn Val Thr 
    1040                 1045                 1050             


Glu Thr  Asp Val Ile Glu Ile  Phe Glu Lys Gly Ser  Val Ile Tyr 
    1055                 1060                 1065             


Lys Met  Asn Lys Lys Leu Lys  Asn Gly Asp Arg Tyr  Ala Phe Thr 
    1070                 1075                 1080             


Ser Ile  Tyr Arg Asn Asn Asn  Asp Glu Lys Leu Glu  Phe Leu Gln 
    1085                 1090                 1095             


Ile Arg  Asn Phe Ile Ala His  Leu His Leu Leu Arg  Lys Ser Glu 
    1100                 1105                 1110             


Trp Lys  Gly Asp Lys Lys Ala  Gly Tyr Ser Val Ile  Glu Asp Tyr 
    1115                 1120                 1125             


Ile Asn  Lys Leu Arg Phe Leu  Leu Ser Tyr Asp Gln  Lys Arg Met 
    1130                 1135                 1140             


Asn Ala  Val Thr Lys Ala Met  Gln Gln Ile Phe Glu  Lys His Lys 
    1145                 1150                 1155             


Val Ile  Val Lys Phe Met Val  Glu Lys Gly Gly 
    1160                 1165                 


<210>  932
<211>  1049
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  932

Met Lys Ala Leu Cys Asp Lys Thr Leu Thr Ala Tyr Gly Lys Ser Phe 
1               5                   10                  15      


Ala Ala Glu Glu Gly Gly Thr Thr Leu Tyr Glu Ala Ile Leu Asn Leu 
            20                  25                  30          


Ala Asn Gly Asn Ala Ile Gln Lys Ala Met Ala Glu Ala Glu Leu Lys 
        35                  40                  45              


Lys Ile Gln Lys Ala Leu Lys Lys Glu Lys Glu Asp Arg Ile Asn Arg 
    50                  55                  60                  


Val Arg Asn Ser Ile Arg Lys Asn Lys Ile Pro Leu Lys Val Asn Ala 
65                  70                  75                  80  


Asp Gly Thr Ile Ser Ala Asn Asn Asp Arg Ala Ala Trp Leu Leu Glu 
                85                  90                  95      


Leu Leu Lys Pro Val Ala Ser Glu His Asp Lys Asp Asp Arg Tyr Pro 
            100                 105                 110         


Val Leu Thr Glu Met Glu Glu Ile Val Ser Phe Asp Lys Leu Cys Glu 
        115                 120                 125             


Glu Val Arg Lys Lys Ile Gln Ser Cys Lys Ser Gly Ala Arg Ser Arg 
    130                 135                 140                 


Ala Met Leu Ala Asp Glu Ala Val Lys Glu Tyr Leu Lys Ala Leu Trp 
145                 150                 155                 160 


Glu Lys His Thr Asp Arg His Arg Asp Met Arg Tyr Tyr Phe Gln Ala 
                165                 170                 175     


Val Lys Glu Tyr Phe Asn Lys Asn Phe Pro Ile Arg Thr Lys Gln Arg 
            180                 185                 190         


Gly Ala Ser Ile Arg Gln Arg Leu Leu Met Glu Glu Thr Val Val Thr 
        195                 200                 205             


Arg Leu Leu Asn Pro Lys His Met Ala Lys Ala Val Arg Arg Lys Leu 
    210                 215                 220                 


Ile Asn Gln Ser Thr Gln Met His Ile Leu Tyr Gly Lys Leu Tyr Glu 
225                 230                 235                 240 


Tyr Cys Cys Arg Lys Gly Arg Asn Leu Pro Val Asn Ser Glu Thr Leu 
                245                 250                 255     


Gln Leu Ile Gln Val Leu Glu Ala Val Lys Lys Gln Leu Met Thr Ala 
            260                 265                 270         


Val Ser Trp Ser Val Ser Arg Leu Cys Tyr Phe Tyr Glu Phe Tyr Ile 
        275                 280                 285             


Gly Asp Ile Leu Leu Ala Gly Lys Tyr Arg Arg Asp Phe Leu Ile Lys 
    290                 295                 300                 


Gln Asn Asn Asn Arg Lys Asp Ile Gln Ala Cys Lys Glu Lys Leu Gln 
305                 310                 315                 320 


Asp Phe Phe Gln Leu Ala Glu Leu Gln Glu Lys Ile Lys Glu Ser Ala 
                325                 330                 335     


Asp Glu Asp Ile Asn Leu Thr Glu Thr Ile Thr Asn Asp Ala Leu Val 
            340                 345                 350         


Cys Asn Lys Leu Leu Glu Glu Cys Ala Phe Cys Ile Ser Lys Leu Arg 
        355                 360                 365             


Asn Asn Ile Phe His Tyr Lys Asn Leu Gly Phe Thr Gln Ala Leu Lys 
    370                 375                 380                 


His Ile Ala Asn Glu Ile Lys Lys Glu Asp Val Pro Val Leu Leu Arg 
385                 390                 395                 400 


Leu Tyr Lys Gln Asp Cys Glu Asn Leu Asn Asn Ala Phe Ala Ser Arg 
                405                 410                 415     


Ile Ser Ser Met Asn Ile Pro Leu Tyr Tyr Ser Thr Glu Phe Leu Leu 
            420                 425                 430         


Arg Ile Phe Lys Lys Gln Gly Val Glu Leu Ser Leu Tyr Ser Ala Lys 
        435                 440                 445             


Tyr Gln Met Thr Pro Ser Phe Lys Arg Val Tyr Glu Arg Gly Lys Asn 
    450                 455                 460                 


Leu Arg Leu Glu Tyr Glu Arg Glu Ser Met Arg Ser Asn Ile Ala Asn 
465                 470                 475                 480 


Glu Asp Gly Asn Asp Leu Gln Asn Gly Asn Trp Leu Arg Trp Phe Ser 
                485                 490                 495     


Gln Leu Glu Ala Gly Ile Val Asp Thr Asp Ala Gly Met Lys Gly Asp 
            500                 505                 510         


Ile Gly Asp Tyr Pro Asp Thr Ser Ala Asp Leu Gly Ile Glu Ala Glu 
        515                 520                 525             


Thr Gly Thr Asn Thr Asp Ala Gln Arg Ala Met Arg Asn Leu Leu Gln 
    530                 535                 540                 


Leu Ile Tyr Lys Tyr His Phe Leu Pro Glu Val Gln Lys Asn Glu Asn 
545                 550                 555                 560 


Ile Val Thr Asp Leu Ile Pro Lys Val Leu Glu Arg Asn Arg Lys Leu 
                565                 570                 575     


Ser Glu Ile Arg Asn Arg Ser Asn Arg Thr Tyr Asp Tyr Gly Tyr Lys 
            580                 585                 590         


Glu Ile Glu Glu Leu Tyr Lys Lys Asn Lys Gly Lys Lys Asp Ser Leu 
        595                 600                 605             


Ser Glu Leu Leu Lys Asp Leu Gln Arg Lys Val Ser Glu Thr Glu Lys 
    610                 615                 620                 


Glu Asn Gln Glu Leu Ala Arg Glu Lys Thr Asp Tyr Ala Gln Arg Phe 
625                 630                 635                 640 


Ile Leu Asp Ile Phe Ala Glu Ala Phe Ser Asn Phe Met Asp Asp Arg 
                645                 650                 655     


Tyr Glu Asp Glu Tyr Gln Glu Ile Met Asn Pro Lys Lys Asp Glu Glu 
            660                 665                 670         


Lys Ala Lys Lys Trp Ala Glu Leu Phe Thr Glu Lys Ala Asp Lys Asp 
        675                 680                 685             


Asn Arg Lys Asp Glu Pro Leu Val Leu Lys Thr Ser Phe Asp Lys Asp 
    690                 695                 700                 


Asn Ile Glu Lys Phe Leu Leu Val Leu Tyr Pro Leu Met Arg Leu Leu 
705                 710                 715                 720 


Asp Asp Lys Glu Leu Ser Glu Leu Gln Gln Gln Met Leu Arg Phe Arg 
                725                 730                 735     


Ala Ser Val Ser Gly Trp Gln Gly Ser Thr Asp Phe Asn Glu Asp Ile 
            740                 745                 750         


Ala Met Ala Glu Lys Ile Glu Glu Leu Ala Glu Leu Val Lys Leu Thr 
        755                 760                 765             


Glu Pro Glu Ser Gln Cys Ala Glu Val Ser Trp Lys Asn Arg Ala Ile 
    770                 775                 780                 


Glu Val Phe Glu Gln Phe Val Glu Gly Lys Met Ala Glu Tyr Gly Ala 
785                 790                 795                 800 


Phe Tyr Leu Gln Ser Asp Thr Leu Thr Pro Val Pro Arg Arg Asn Met 
                805                 810                 815     


Lys Glu Leu Leu Arg Ser Gly Ile Met Gly Val Phe Lys Lys Val Leu 
            820                 825                 830         


Leu Ser His Met Gln Ala Thr Lys Lys Asp Tyr Gly Val Tyr Ser Gly 
        835                 840                 845             


Glu His Trp Asn Ile Asp Asp Pro Ala Gly Asn Pro Ile Lys Ser Ala 
    850                 855                 860                 


Glu Gln Ala His Ala Leu Leu Gln Arg Leu His Asn Lys Tyr Thr Glu 
865                 870                 875                 880 


Ser Pro Ser Gln Phe Ser Tyr Glu Asp Tyr Lys Leu Tyr Asp Arg Thr 
                885                 890                 895     


Ile Arg Gln Leu Asp Glu Tyr Asn Gln Ala Lys Lys Asn Leu Ser Phe 
            900                 905                 910         


Gly Ser Leu Tyr Glu Val Cys Arg Ile Leu Leu Asp Met Leu Ser Arg 
        915                 920                 925             


Trp Val Gly Phe Val Gln Asp Trp Glu Arg Asp Met Tyr Phe Leu Leu 
    930                 935                 940                 


Leu Ala Trp Ala Lys Gln Gly Lys Leu His Asn Val Thr Glu Thr Asp 
945                 950                 955                 960 


Val Leu Glu Val Phe Asn Glu Gly Arg Val Ile Cys Lys Leu Asn Lys 
                965                 970                 975     


Lys Leu Lys Asp Gly Asp Trp His Ala Phe Ala Ser Ile Tyr Cys Asn 
            980                 985                 990         


Asn Ser Gly Glu Lys Leu Glu Phe  Leu Gln Val Arg Asn  Phe Ile Ala 
        995                 1000                 1005             


His Leu  His Leu Leu Arg Glu  Ser Glu Trp Asn Gly  Asp Glu Lys 
    1010                 1015                 1020             


Thr Gly  Cys Ser Ala Ile Glu  Asp Tyr Ile Asn Lys  Leu Arg Phe 
    1025                 1030                 1035             


Leu Leu  Ser Tyr Asp Gln Lys  Arg Met Asn Ala 
    1040                 1045                 


<210>  933
<211>  1373
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  933

Met Ala Lys His Leu Arg Pro Ile Gly Glu Ser Tyr Thr Asp Phe Leu 
1               5                   10                  15      


Asp Glu Thr Glu Phe Val Arg Leu Gly Arg Gly Leu His Arg Gly His 
            20                  25                  30          


His Gly Val Gln Ile Pro Pro Thr Glu Leu Pro Ser Tyr Leu Ala Glu 
        35                  40                  45              


Tyr Arg Lys Ala Leu Met Arg Gln Val Val Ala Val Leu Asp Lys Val 
    50                  55                  60                  


Val Gly Lys Arg Arg Arg Leu Ser Gly Met His Pro Glu Ala Tyr Arg 
65                  70                  75                  80  


Asp Arg Val His Leu Ala Glu Ala Leu Trp Val Arg Leu Val Ala Arg 
                85                  90                  95      


Val Lys Glu Ile Gly Thr Pro Pro Asp Pro Ser Glu Leu Leu Asp Leu 
            100                 105                 110         


Arg Arg Met Trp Asn Ala Lys Ala His Pro Tyr Ala Glu Tyr Asp Val 
        115                 120                 125             


Val Pro Arg Ala Pro Leu Asn Asp Gly Asn Gly Gln Lys Ile Leu Glu 
    130                 135                 140                 


Cys Arg Glu Val Asp Asp Pro Lys Ile Glu Arg Ser Asp Phe Glu Gly 
145                 150                 155                 160 


Arg Trp His Gly Arg Phe Trp Gln Ser Glu Pro Gly Pro Val Asp Tyr 
                165                 170                 175     


Asn Ala Ile Ala Asp Arg Ile Phe Ala His Leu Phe Asp Gln Glu Ala 
            180                 185                 190         


Val Ile Gly Gly Gly Pro Arg Arg Glu Gly Asn Val Thr Val Pro Asp 
        195                 200                 205             


Glu Asp Ile Asn Gly Gln Pro Gly Pro Ala Thr Gly Lys Gly Leu Ile 
    210                 215                 220                 


Ile Ala Arg Gly Gln Ser Ile Val Lys Ser Ala Ser Asp Pro Arg Arg 
225                 230                 235                 240 


Ser Ser Lys Lys Val Gln Arg Thr Trp Asp Lys Ala Val Glu Arg Arg 
                245                 250                 255     


Tyr Phe Gly Asp Asp Gly Lys Gly Gly Ser Asp Ile Ala Lys Ala Ile 
            260                 265                 270         


Tyr Glu Glu Leu Gly Asp Pro Ala Thr Leu Ala Asp Pro Ile Tyr Ala 
        275                 280                 285             


Ser Trp Phe Gly Ser Arg Leu Tyr Asp His Phe Gly Ser Phe Lys Asn 
    290                 295                 300                 


Ser Leu Pro Leu Glu Leu Lys Asp Pro Phe Lys Glu Gln Ile Trp Ala 
305                 310                 315                 320 


Leu His Asn Ser Val Arg Gln Phe Tyr Gln Arg Met Ala Lys Ser Asp 
                325                 330                 335     


Arg Phe Arg Leu Ala Leu Gln Asn Ala Arg Ser Glu Val Pro Asp Arg 
            340                 345                 350         


Ser Glu Leu Leu Ala Leu Leu Pro Lys Asp His Asp His Leu Leu Leu 
        355                 360                 365             


Val Leu Gly Gly Lys Lys Lys Asn Ala Glu Met Ser Glu Leu Ile Arg 
    370                 375                 380                 


Leu Gly Lys Leu Phe Val His Ala Ser Asp Val Leu His Asp Phe Asp 
385                 390                 395                 400 


Ala Asn Asp Ala Ala Ala Leu Asp Ala Phe Lys Arg Arg Met Ser Phe 
                405                 410                 415     


Leu Ala Thr Ser Ile Gly Gln Ser Glu Ile Lys Gln Thr Glu Thr Phe 
            420                 425                 430         


Ala Arg Thr Trp Arg Gly Ala Val Gly Leu Thr Leu Arg Thr Val Lys 
        435                 440                 445             


Gly Leu Ala Asp Pro Arg Gly Ile Ile Gly Thr Pro Asp Asn Arg Asp 
    450                 455                 460                 


Leu Gly Thr Ala Gly Pro Met Lys Asp Ala Phe Asn Lys Phe Asp Gln 
465                 470                 475                 480 


Pro His Phe Gln Gln His Met Thr Ile Ile Phe Gly Asn Lys Glu Leu 
                485                 490                 495     


Gln Ala Glu Gly Asn Pro Thr Arg Ser Ser Val Phe Thr Ala Asn Gly 
            500                 505                 510         


Asp Lys Asp His Gln Ala Glu Leu Leu Trp Gly Phe Leu Cys Val Val 
        515                 520                 525             


Arg Ser Val Arg Asn Arg Thr Asn His Tyr Asn Val Arg Arg Ala Leu 
    530                 535                 540                 


Leu Arg Leu Leu Asp Glu Gly Ile Val Ser Pro Met Pro Ser Asp Pro 
545                 550                 555                 560 


Lys Lys Glu Arg Val Glu Asn Arg Asn Leu Cys Thr Val Ser Pro Thr 
                565                 570                 575     


Ala Leu Glu Ala Phe Arg Arg Leu Leu Asn Phe Asp Leu Ala Ile Gln 
            580                 585                 590         


Lys Glu Ala Val Arg Thr Ala Leu Glu Gln Ala Lys Ala Ser Glu Phe 
        595                 600                 605             


Val Glu Glu Gly Lys Leu Arg Gly Leu Val Ser Glu Leu Ala Gly Thr 
    610                 615                 620                 


Glu Asp Met Pro Ala Leu His Ile Pro Arg Phe Ser Ala Val Met Asp 
625                 630                 635                 640 


Lys Val Arg Arg Leu Ala Asp Asn Arg Asp Val Gly Leu Asp Pro Ile 
                645                 650                 655     


Leu Ser Thr Leu Gln Arg Ser Leu Pro Pro Thr Asp Lys Gln Ala Glu 
            660                 665                 670         


Ser Asp Ala Ala Arg Cys Arg Tyr Arg Leu Leu Leu Glu Leu Tyr Lys 
        675                 680                 685             


Ser Gly Phe Arg Ser Trp Phe Ser Gly Ile Gln Ser Asn Glu Glu Asn 
    690                 695                 700                 


Asn Arg Glu Ile Cys His Trp Ala Val Lys Gln Val Gly Arg Ala Lys 
705                 710                 715                 720 


Asp Ala Arg Lys Ser Glu Tyr Asp Lys Lys Thr Lys Arg His Tyr Arg 
                725                 730                 735     


Ser Pro Asn Ser Leu Ile Asp Asp Leu Gly Leu Asp Lys Phe Asp Asp 
            740                 745                 750         


Leu Thr Asp Leu Leu Glu Ala Leu Ala Ser Gln Ser Thr Arg Glu His 
        755                 760                 765             


Asp Gln Asn Leu Lys Tyr Val Pro Asp Ala Arg Val Gln Ser Gln Met 
    770                 775                 780                 


Ser Asn Arg Ile Glu Glu Phe Arg Gln Glu Leu Phe Ala His Ile Phe 
785                 790                 795                 800 


Thr Lys Tyr Leu Asp Thr His Asp Phe Gly Trp Ile Gly Ala Ile Glu 
                805                 810                 815     


Val Arg Arg Glu Ala Cys Asp Leu Ala Asp Val Val Ser Ala Phe Glu 
            820                 825                 830         


Val Arg Asp Gln Lys Phe Asp Ala Asp Trp His Ser Gln Phe Tyr Ala 
        835                 840                 845             


Trp Leu Tyr Met Val Pro Pro Ile Glu Ala Ser Arg Leu Arg His Gln 
    850                 855                 860                 


Met Arg Lys Ser Ala Val Met Asp Asp Lys Trp Ser Thr Thr Leu Glu 
865                 870                 875                 880 


Leu Thr Ser Gly Asp Arg Lys Thr Arg Asp Asp His Ala Gln Asp Val 
                885                 890                 895     


Leu Ala Asp Met Asp Arg Leu Phe Ser Leu Tyr Thr Lys Val Gln Ala 
            900                 905                 910         


Ala Gly Phe Asn Gly Gln Glu His Glu Ser Ala Leu Gly Ser Lys Ser 
        915                 920                 925             


Leu Phe Tyr Glu Asp Gly Asn Gln Phe Asp Glu Val Tyr Ser Pro Asp 
    930                 935                 940                 


Thr Glu Thr His Asn Lys Thr Phe Pro Gly Thr Arg Arg Gly Leu Arg 
945                 950                 955                 960 


Gln Leu Val Arg Tyr Ala His Leu Pro Ala Leu Glu Gly Val Phe Lys 
                965                 970                 975     


Lys His Arg Ile Thr Lys Ala Glu Val Glu Thr Phe Val Ala Leu Tyr 
            980                 985                 990         


Asp Glu Asn Arg Arg Asp Pro Gly  Ser Val Ala His Met  Leu Arg Arg 
        995                 1000                 1005             


Glu Lys  Leu Arg Thr Glu Ile  Leu Arg Ser Ile His  Asp Gly Pro 
    1010                 1015                 1020             


Lys Pro  Lys Asp Lys Asp Phe  Trp Pro Lys Leu Glu  Ala Lys Cys 
    1025                 1030                 1035             


Leu Glu  Tyr Arg Thr Val Ala  Thr Glu Thr Ala Ile  Tyr Asn Phe 
    1040                 1045                 1050             


Gln Ala  Asn Ala Ala Arg Leu  Asn Asp His Ala Arg  Leu His Gln 
    1055                 1060                 1065             


Ile Val  Met Arg Val Val Ala  Arg Leu Thr Asp Tyr  Ala Leu Ile 
    1070                 1075                 1080             


Trp Glu  Arg Asp Arg Leu Phe  Ala Phe Val Gly Met  Leu Tyr Arg 
    1085                 1090                 1095             


Gln Thr  Gly Gly Thr Gly Ile  Asn Pro Ala Met Arg  His Ala Glu 
    1100                 1105                 1110             


Lys Thr  Asn Ala Pro Pro Arg  Ile Gly Ile Leu Val  Ser Asp Ser 
    1115                 1120                 1125             


Ala Leu  Ala Lys Lys Leu Asn  Ser Asn Ser Ala Glu  Val Phe Ile 
    1130                 1135                 1140             


Pro Tyr  Leu Asp Thr Glu Thr  Gly Phe Asp Ala Pro  Arg Phe Asp 
    1145                 1150                 1155             


Asp Leu  Cys Thr Leu Leu Ser  His Glu His Ala Lys  Glu Phe Arg 
    1160                 1165                 1170             


Phe His  Phe Leu Glu Val Gly  Glu Glu Asn Ser Lys  Asp Glu Ala 
    1175                 1180                 1185             


Arg Arg  Leu Asn Glu Glu Thr  Met Gly His Arg Lys  Arg Pro Ala 
    1190                 1195                 1200             


Phe Lys  Arg Gly Thr Arg Arg  Gln Gly Ile Arg Asn  Asp Leu Ala 
    1205                 1210                 1215             


His His  Asn Val Leu Asp Leu  Ala Gly Gly Ala Gly  Pro Asn Leu 
    1220                 1225                 1230             


Thr Tyr  Val Val Asn Ala Val  Arg Ser Leu Leu Ser  Tyr Asp Arg 
    1235                 1240                 1245             


Lys Leu  Lys Asn Ala Val Pro  Lys Ser Ile Lys Arg  Ile Leu Gly 
    1250                 1255                 1260             


Glu Glu  Gly Leu Ile Ile Glu  Trp Gln Met Asn Tyr  Asp Arg Leu 
    1265                 1270                 1275             


Lys Lys  Pro Thr Val Tyr Pro  Asn Val Glu Thr His  Leu Thr Met 
    1280                 1285                 1290             


Val Pro  Pro Arg His Met Thr  Ala Pro Val Ser Phe  Thr Leu Pro 
    1295                 1300                 1305             


Arg Ala  Ser Val Arg Leu Ala  Ser Met Val Lys Ala  Val Phe Asp 
    1310                 1315                 1320             


Phe Gly  Ser Ser Gly Tyr Gly  Glu Glu Arg Met Ile  Gly Gly Arg 
    1325                 1330                 1335             


Thr Ala  Lys Gln Ala Val Tyr  Pro Asp Asp Phe Thr  Arg Arg Phe 
    1340                 1345                 1350             


Pro Gln  Thr Pro Met Gly Leu  Lys Gln Ala Thr Arg  Leu Val Phe 
    1355                 1360                 1365             


Ala Ser  Glu Asn Ser 
    1370             


<210>  934
<211>  1287
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  934

Met Arg Ile Gly Lys Val Gln Gly Arg Thr Phe Thr Gly Phe Asp Asn 
1               5                   10                  15      


Ala Arg Gly Lys Thr Leu Arg Arg Arg Leu Leu Thr Arg Pro Asp Asn 
            20                  25                  30          


Glu Ala Arg Ser Leu Ser Glu His Leu Ala His Asp Pro Lys Ala Leu 
        35                  40                  45              


Ile Gly Gln Ala Ile Ser Arg Ile Asp Thr Ile Tyr Gln Lys Pro Lys 
    50                  55                  60                  


Thr Gly Lys Pro Thr Pro Glu Gln Phe Gly His Arg Asp Thr Leu Gly 
65                  70                  75                  80  


Trp Ala Tyr Trp Lys Leu Leu Val Ala Ser Tyr Pro Glu Val Glu Gly 
                85                  90                  95      


His Arg Asp Leu Phe Val Arg Arg Leu His Pro Tyr Gly Asp Thr Pro 
            100                 105                 110         


Pro Lys Ser His Gly Gln Lys Glu Gly Glu His Gln Lys Gly Gly Lys 
        115                 120                 125             


Pro Gln Leu Glu Gly Arg Trp His Gly Val Met Ala Gln His Gly Lys 
    130                 135                 140                 


Asn Pro Asp Gln Ile Ala Ala Arg Leu Phe Asp His Leu His Asn Ser 
145                 150                 155                 160 


Glu Leu Arg Phe Gly Gly Thr Ala Ser Gly Glu Pro Arg Thr Arg Pro 
                165                 170                 175     


Gly Lys Glu Ala Thr Pro Thr Gly Leu Ile Gly Ala Arg Ala Lys Thr 
            180                 185                 190         


Ile Glu His Ser Val Leu Pro Arg Asp Ala Lys Arg Phe Val Ala Glu 
        195                 200                 205             


Trp Arg Gly Glu Asp Gln Glu Arg Tyr Ala Gly Ala Arg Asp Ile Ala 
    210                 215                 220                 


Ala Ala Ile Ser Ala Gly Leu Asn Asp Lys Asp Gln Lys Ser Gly Ser 
225                 230                 235                 240 


Gly Arg Lys Ser Ala Val Ile Gly Lys Leu Leu Ser Asp His Leu Glu 
                245                 250                 255     


Thr Leu Thr Gly Asn Arg Lys Cys Arg Phe Asp Pro Lys Ser Thr Ala 
            260                 265                 270         


Glu Thr Leu Glu Leu Arg Asp Gly Glu Ser Val Asp Asp Arg Arg Arg 
        275                 280                 285             


Ile Leu Glu Leu His Ala Glu Val Lys Ala Thr Tyr Lys Arg Met Ala 
    290                 295                 300                 


Ala Trp Lys Pro Ala Lys Leu Pro Arg Asn Ser Asp Glu Leu Phe Arg 
305                 310                 315                 320 


Leu Val Arg Gln Gln Ala Asp Asn Arg Ile Leu Asn His Leu Val Arg 
                325                 330                 335     


Val Gly Arg Ile Ser Val Tyr Ser Glu Gln Ser Asp Ala Leu Ser Glu 
            340                 345                 350         


Ser Gln Phe Trp Thr Ser Gly Gly Gln Thr Gln Ile Lys Glu Ser Glu 
        355                 360                 365             


Val Phe Ala Arg Leu Trp Ile Gly Ala Ile Ser Arg Ala Ser Tyr Ser 
    370                 375                 380                 


Met Lys Ala Trp Leu Glu Pro Glu Gly Thr Val Phe Asn Pro Ser Ile 
385                 390                 395                 400 


Asn Asp Phe Asp Val Thr Ser Ser His Asn Thr Asn Arg Ile Leu Glu 
                405                 410                 415     


Asp Ser Gly Arg Leu Ser Asn Ala Met Ala Arg Arg Ala Ile Tyr Phe 
            420                 425                 430         


Gly Glu Thr Pro Glu Phe Asp Ala Leu Gly Glu Glu Asp Gln Arg Val 
        435                 440                 445             


Leu Val Lys Lys Cys Leu Asp Ala Leu Ser Ala Cys Arg Asn Arg Thr 
    450                 455                 460                 


Phe His His Gly Gln Arg Ala Lys Phe Leu Lys Glu Val Arg Lys Gly 
465                 470                 475                 480 


Leu Lys Glu Lys Glu Ala Asp Ser Ala Gly Pro Ala Ala Trp Glu Gly 
                485                 490                 495     


Ile Arg Glu Val Ile Gln Ala Asp Ala Arg Asn Leu Gly Ala Arg Leu 
            500                 505                 510         


Leu Gln Asp Leu Thr Gly Ala Lys Val His Ser Phe Ala Thr Asp Pro 
        515                 520                 525             


Glu Phe Arg His Leu Tyr Glu Ser Val Ala Ala Thr Leu Thr Ala Gly 
    530                 535                 540                 


Gly Glu Leu Glu Ala Ala Leu Pro Arg Leu Lys Asn Val Leu Lys Arg 
545                 550                 555                 560 


Ala Glu Gly Val Arg Cys Tyr Leu Asp Thr Pro Ser Gln Arg Arg Glu 
                565                 570                 575     


Gly Asp Glu Ser Leu Ile Ala Arg Leu Pro Val Ala Pro Val Pro Arg 
            580                 585                 590         


Glu Leu Asp Asp Ala Ala Thr Lys Ala Arg His Ser Ala Leu Leu Arg 
        595                 600                 605             


Leu Tyr Asp Gly Pro Phe Arg Pro Trp Ala Thr Glu Leu Arg Gly Glu 
    610                 615                 620                 


Arg Leu Ser Asp Tyr Ala Ala Arg Ala Lys Arg Leu Ala Thr Arg Leu 
625                 630                 635                 640 


Ala Lys Ser Thr Asn Thr Ala Ser Pro Tyr Pro Asp Ser Val Glu Gly 
                645                 650                 655     


Arg Ser Val Arg Leu Arg Asp Pro Ile Thr Ala Asp Thr Ala Pro Glu 
            660                 665                 670         


Thr Leu Lys Thr Tyr Leu Ser Ala Leu Thr Ala Glu Thr Ala Thr Glu 
        675                 680                 685             


Phe Arg Val Gln Lys Gly Tyr Glu Ser Asp Gly Glu Lys Ala Lys Glu 
    690                 695                 700                 


Gln Ala Glu Phe Ile Glu Asp Phe Arg Arg Asp Met Ile Ala Leu Ala 
705                 710                 715                 720 


Phe Gln Asp Phe Ile Arg Asp His Gly Phe Ala Trp Leu Leu Asp Ile 
                725                 730                 735     


Ala Ser Lys Ala Glu Pro Ser Asn Asp Ala Pro Asn Leu Pro Asp Pro 
            740                 745                 750         


Val Asp Thr Gly Lys Asp Thr Val Phe Glu Asp Trp Gln Ala Leu Leu 
        755                 760                 765             


Tyr Leu Phe Leu His Phe Val Pro Ala Asp Asp Val Ser Gln Leu Leu 
    770                 775                 780                 


His Gln Leu Arg Lys Trp Asp Ala Leu Gln Asp Lys Tyr Glu Leu Ala 
785                 790                 795                 800 


Glu Pro Gly Glu Thr Leu Gly Gln Thr Lys Ala Asp Thr Arg Lys Ile 
                805                 810                 815     


Val Gly Gln Phe Arg Asp Cys Leu Thr Leu Phe Leu Lys Thr Gly Asp 
            820                 825                 830         


Ala Arg Phe Asp Gly Glu Gly Val Glu Leu Pro Leu Ser Asp Phe Gln 
        835                 840                 845             


Glu Leu Phe Glu Ser Pro Ala Thr Phe Lys Glu Leu Phe Leu Ala Glu 
    850                 855                 860                 


Pro Ala Glu Asn Asp Ala Ser Glu Thr Asp Asp Gln Asp Ala Pro Gly 
865                 870                 875                 880 


Glu Lys His Arg Val Thr Arg Thr Arg Arg Gly Leu Arg Gln Ile Leu 
                885                 890                 895     


Arg Tyr Asn His Met Pro Val Leu Arg Asp Leu Phe Leu Ala His Lys 
            900                 905                 910         


Val Thr Asp Ala Glu Val Asp Gly Leu Gln Ala Leu Glu Val Asp Asp 
        915                 920                 925             


Pro Gln Thr Gly Glu Ser Gln Ile Gly Ala Ala Gln Arg Ile Arg Thr 
    930                 935                 940                 


Glu Ile His His His Thr Ser Asn Asp Lys Gln Ile Ser Glu Ala Lys 
945                 950                 955                 960 


Val Glu Glu Tyr Arg Arg Ala Leu Ser Thr Ile Glu Arg His Arg Phe 
                965                 970                 975     


Leu Val Gly Arg Val Tyr Leu Gly Asp His Ile Arg Val His Lys Leu 
            980                 985                 990         


Met Met Asp Val Met Gly Arg Leu  Val Asp Phe Ala Gly  Ala Trp Glu 
        995                 1000                 1005             


Arg Glu  Ala Ala Asp Gly Asp  Arg Lys Gly Phe Ile  Ser Arg Ala 
    1010                 1015                 1020             


Ile Ala  Leu Pro Glu Val Ala  Glu Gly Tyr Ala Ala  Asp Arg Leu 
    1025                 1030                 1035             


Lys Thr  Val Ala Arg Arg Val  Leu Asp Asp Gly Glu  Ala Arg Arg 
    1040                 1045                 1050             


Ile Arg  Asn Asp Leu Gly His  Phe Asn Asp Leu Ala  Pro Thr Ser 
    1055                 1060                 1065             


Gly Pro  Ala Asn Leu Thr Phe  Val Val Asn Arg Ala  Arg Arg Met 
    1070                 1075                 1080             


Met Arg  His Asp Arg Lys Arg  Lys Asn Ala Val Thr  Lys Ser Val 
    1085                 1090                 1095             


Ile Glu  Ile Leu Asn Arg Gln  Gly Leu Gly Ile Glu  Trp Thr Met 
    1100                 1105                 1110             


Arg Asn  His Glu Leu Cys Glu  Ala Lys Leu Trp Gln  Asn Pro Val 
    1115                 1120                 1125             


Lys His  Leu Gly Phe Ala Thr  Leu Glu Gly Arg Gly  Lys Lys Trp 
    1130                 1135                 1140             


Arg Arg  Pro Phe Glu Ala Arg  Tyr Gly Asp Ala Tyr  Met Ala Met 
    1145                 1150                 1155             


Val Ala  Gln Leu Phe Asp Gly  Thr Val Thr Ser Pro  Pro Ala Lys 
    1160                 1165                 1170             


Gly Pro  Pro Gln Ser Gly Lys  Ser Gly Gly Lys Pro  Gly Lys Gly 
    1175                 1180                 1185             


Ala Glu  Gly Gly Ala Lys Glu  Lys Ser Arg Ser Pro  Thr Arg Met 
    1190                 1195                 1200             


Glu Glu  Gly Gly Val Tyr Glu  Gly Arg Val Ala Lys  Ala Lys Ser 
    1205                 1210                 1215             


Asp Lys  Gly Phe Gly Phe Leu  Leu Val Glu Gly Ala  Gln Glu Glu 
    1220                 1225                 1230             


Ile Phe  Leu His Ile Tyr Gly  Ile Ser Gly Asn Arg  Pro Ala Arg 
    1235                 1240                 1245             


Ile Glu  Asn Gly Gln Arg Tyr  Arg Phe Thr Leu Gly  Ile Asp Arg 
    1250                 1255                 1260             


Asp Arg  Glu Arg Arg Lys Glu  Arg Ala Trp Val Ala  Arg Glu Ala 
    1265                 1270                 1275             


Val Arg  Ile Asp Glu Asn Arg  Ser Lys 
    1280                 1285         


<210>  935
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  935

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Leu Tyr Gln Ile Val  Ser Ala Phe Asn Phe  Gly Ser Lys 
    1205                 1210                 1215             


Leu Leu  Tyr Ile Ser Glu Asp  Gly Arg Trp Lys Met  Ala Gly Gly 
    1220                 1225                 1230             


Ala Phe  Pro Gly Lys Tyr Gly  Arg Phe Glu Asn Asp  Tyr Asn His 
    1235                 1240                 1245             


Arg Thr  Ser Leu Ser Lys Val  Ile Arg Leu Phe Glu  Asn Glu Ser 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ile Ile Tyr  Trp Arg Asp Tyr Val  Asp His Met 
    1265                 1270                 1275             


Lys Tyr  Tyr Val Asn Gln Asn  Gln Ser Ile Met Glu  Ile Tyr Ser 
    1280                 1285                 1290             


Ala Phe  Tyr Ser Lys Val Leu  Gly Tyr Ser Ala Lys  Leu Arg Lys 
    1295                 1300                 1305             


Ser Val  Val Phe Asn Leu Gln  Ala Ala Leu Glu Lys  His His Ile 
    1310                 1315                 1320             


Asn Pro  Glu Cys Ile Trp Met  Thr Ser Asp Gly Lys  Cys Ala Asp 
    1325                 1330                 1335             


Ile Lys  Leu Met Lys Asn Leu  Glu Ser Gln Lys Phe  Thr Tyr Lys 
    1340                 1345                 1350             


Leu Ala  Lys Arg Glu Gly Glu  Lys Thr Glu Arg Lys  Ile Cys Met 
    1355                 1360                 1365             


Asn Ala  Leu Asn Glu Asn Phe  Leu Lys Thr Ile Arg  Thr Ser Leu 
    1370                 1375                 1380             


Glu Tyr  Lys Lys 
    1385         


<210>  936
<211>  1102
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  936

Met Arg Val Ser Lys Val Lys Val Asp Asn Lys Asn Met Val Leu Met 
1               5                   10                  15      


Arg Arg Thr Thr Gly Asn Gly Ala Leu Val Tyr Glu Gly Glu Thr Ser 
            20                  25                  30          


Asn Arg Thr Ile Glu Ile Leu Pro Lys Gln Lys Ile Gln Ser Phe Ser 
        35                  40                  45              


Leu Ser Ile Glu Asn Lys Thr Leu Ile Lys Arg Asp Ser Leu Lys Gly 
    50                  55                  60                  


Thr Val Gln Lys Asn Lys Tyr Asp Val Ile Arg Ala Ile Ile Lys Tyr 
65                  70                  75                  80  


Asn Arg Phe Pro Asp Arg Ile Ser Ala Glu Glu Val Leu Pro Phe Leu 
                85                  90                  95      


Asn His Lys Phe Gln Asn Glu Ile Lys Tyr Tyr Asn Asp Asn Lys Leu 
            100                 105                 110         


His Ser Phe Leu Leu Thr Ser Leu Ile Val Glu Ala Val Lys Glu Lys 
        115                 120                 125             


Asn Pro Gln Lys Leu Gln Pro Tyr Phe Asp Trp Glu Glu Trp Tyr Ile 
    130                 135                 140                 


Ser Asn Lys Ser Asn Ala Leu Ile Lys Ser Ile Glu Asn Asn Lys Ile 
145                 150                 155                 160 


Asp Ser Glu Lys Lys Asp Ser Lys Arg Lys Lys Thr Leu Gln Thr Trp 
                165                 170                 175     


Ala Ala Glu Tyr Thr Asp Asn Gly Ser Ile Asp Leu Ser Glu Tyr His 
            180                 185                 190         


Asn Ile Tyr Asp Ile Asp Thr Leu Val Arg Ala Leu Ile Lys Ala Asp 
        195                 200                 205             


Lys Gly Glu Leu Lys Glu Asp Gly Thr Pro Lys Asn Ala Asn Ala Phe 
    210                 215                 220                 


His Arg Asn Leu Lys Arg Thr Leu Gln Asp His Gln Lys Thr Val Phe 
225                 230                 235                 240 


Gly Thr Arg Glu Ala Ser Asn Met Thr Asn Arg Glu Asn Asp Gln Leu 
                245                 250                 255     


Ala Val Tyr His Leu Glu Val Val Lys Tyr Leu Glu His Tyr Phe Ser 
            260                 265                 270         


Val Lys Ser Thr Gln Arg Arg Asn Thr Arg Ala Asp Ile Asp Tyr Tyr 
        275                 280                 285             


Leu Lys Ala Glu Thr Ile Lys Asn Ile Ile Thr Lys Gln Leu Leu Asn 
    290                 295                 300                 


Ala Val Arg Asn Tyr Leu Leu Gln Gln Gly Lys Ala Gln His His Lys 
305                 310                 315                 320 


Phe Ala Glu Ile Lys Pro Asp Ser Asn Ser Leu Thr Glu Ile Lys Arg 
                325                 330                 335     


Asn Glu Ala Phe Val Leu Asn Met Ile Asp Ala Cys Gly Phe Ala Ala 
            340                 345                 350         


Asn Asn Ile Arg Asn Ile Val Asp Ala Glu Gln Ile Asn Asp Ile Leu 
        355                 360                 365             


Ser Lys Lys Glu Tyr Val Gln Ser Leu Asp Ser Asn Arg Val Asn Asn 
    370                 375                 380                 


Gln Leu Phe Lys Phe Phe Phe Gly Thr Asp Leu Pro Glu Thr Ala Thr 
385                 390                 395                 400 


Asp Lys Val Lys Thr Leu Trp Ala Met Arg Gly Ala Val Gln Gln Ile 
                405                 410                 415     


Arg Asn Lys Val Val His Tyr Lys Gln Lys Ala Leu Asp Ala Ile Phe 
            420                 425                 430         


Asn Val Thr Asp Phe Glu Tyr Pro Ser Phe Asn Asn Ser Ile Tyr Thr 
        435                 440                 445             


Asp Thr Ile Tyr Lys Asp Cys Leu Glu Thr Glu Leu Gln Lys Leu Pro 
    450                 455                 460                 


Glu Ala Phe Ala Gln Gln Leu Lys Thr Gly Gly Ala Leu Thr Tyr Tyr 
465                 470                 475                 480 


Pro Phe Asp Asp Leu Lys Thr Leu Leu Asn Lys Val Ala Phe Ser Leu 
                485                 490                 495     


Cys Arg Ser Val Val Pro Phe Ala Pro Gly Phe Lys Lys Val Gln Lys 
            500                 505                 510         


Gln Gly Gln Asn Tyr Gln Asn Ala His Lys Glu Asn Phe Tyr Asn Leu 
        515                 520                 525             


Asp Leu Lys Ser Tyr Leu Pro Lys Glu Lys Phe Asp Glu Glu Ala Tyr 
    530                 535                 540                 


Asn Ala Arg Tyr Phe Leu Leu Lys Leu Ile Tyr Asn Asn Leu Phe Leu 
545                 550                 555                 560 


Ser Asp Phe Thr Gly Asn Arg Glu Gln Phe Ser Ala Thr Val Asn Tyr 
                565                 570                 575     


Ile Leu Lys Arg Asn Lys Lys Gln Ala Glu Asn Ser Arg Arg Pro Lys 
            580                 585                 590         


Ala Tyr Ala Phe Glu Ala Val Arg Gln Met Lys Lys Glu Glu Ser Ile 
        595                 600                 605             


Thr Ser Tyr Met Ala Tyr Ala Gln Asn Gln Leu Met Val Glu Lys Asn 
    610                 615                 620                 


Lys Lys Glu Asp Asp Lys Pro Glu Asp Ile Arg Ile Asn Phe Glu Lys 
625                 630                 635                 640 


Phe Val Leu Gln Val Phe Ile Lys Gly Phe Asp Asp Phe Leu Leu Asn 
                645                 650                 655     


Glu Lys Phe Lys Phe Ile Ala Thr Pro Cys Phe Gln Leu Ser Lys Glu 
            660                 665                 670         


Asn Thr Lys Gln Gln Gln Ala Asp Val Leu Asn Gln Phe Glu Gln Arg 
        675                 680                 685             


Ile Ile Lys Glu Cys Arg Phe Gln Ser His Thr Ile Lys Ala Glu Glu 
    690                 695                 700                 


Ala Lys His Val Ala Phe Phe Thr Phe Cys Lys Leu Leu Asp Ala Thr 
705                 710                 715                 720 


His Leu Ser Asn Leu Arg Asn Glu Leu Ile Lys Phe Lys Gln Ser Ser 
                725                 730                 735     


Lys Gln Phe Glu Leu Cys His Val Leu Glu Ile Ile Glu Leu Ser Leu 
            740                 745                 750         


Leu Asn Ala Asp Val Val Pro Ala Asp Tyr Arg Glu Leu Tyr Ala Asn 
        755                 760                 765             


Lys Val Thr Cys Leu Asn Arg Val Arg Pro Phe Ile Ala Asp Gly Val 
    770                 775                 780                 


Asp Ile Thr Lys Trp Ser Gly Leu Phe Ile Gln Thr Asp Asn Glu Thr 
785                 790                 795                 800 


Pro Val Ile His Ala Asn Val Glu Leu Thr Val Lys Tyr Gly Thr Thr 
                805                 810                 815     


Lys Leu Leu Glu Gln Leu Ile Ala Lys Gly Ala Ser Phe Lys Leu Ser 
            820                 825                 830         


Glu Ser Asp Phe Asn Leu Trp Asn Ser Ala Lys Asp Thr Ile Lys Glu 
        835                 840                 845             


Val Ile Asn Lys Arg Leu Ser Leu His Lys Gln Trp Glu Asp Ala Ile 
    850                 855                 860                 


Arg Lys Asp Lys Glu Glu Lys Asn Lys Arg Val Lys Thr Arg Ser Asn 
865                 870                 875                 880 


Phe Ala Gln Gln Phe Ile Asn Lys Glu Arg Asp Ser Tyr Phe Asp Leu 
                885                 890                 895     


Cys Asp Tyr Ile Asp Ala Tyr Asn Trp Tyr Asp Ser Lys Leu His Phe 
            900                 905                 910         


Val Asn Leu Ile Arg Leu His His Leu Thr Ile Asp Ile Leu Gly Arg 
        915                 920                 925             


Met Val Gly Phe Val Ala Ile Trp Glu Arg Asp Phe Gln Tyr Met Thr 
    930                 935                 940                 


Glu Ser Ile Ser Pro Met Asn Ser Ser Lys Glu Leu Asp Phe Thr Lys 
945                 950                 955                 960 


Gly Phe Pro Leu Leu Lys Gly Ile Gln Leu Asp Tyr Tyr Lys Arg Ile 
                965                 970                 975     


Phe Leu Ser Gly Asn Tyr Arg Asp Ile Arg Asn Tyr Ile Ala His Phe 
            980                 985                 990         


Asn Tyr Leu Thr Asp Ser Lys Phe  Ser Met Ile Asp Leu  Ile Asn Glu 
        995                 1000                 1005             


Leu Arg  Glu Leu Leu Ser Tyr  Asp Arg Lys Leu Lys  Asn Ala Val 
    1010                 1015                 1020             


Asn Lys  Ala Phe Ile Asp Leu  Phe Asp Lys Gln Gly  Met Val Leu 
    1025                 1030                 1035             


Lys Leu  Lys Leu Asn Asp Ala  His Arg Phe Glu Ile  Glu Ser Val 
    1040                 1045                 1050             


Glu Pro  Lys Leu Leu Tyr His  Leu Gly Thr Thr Pro  Ala Arg Asp 
    1055                 1060                 1065             


Pro Ile  Ser Thr Tyr Gln Val  Lys Pro Gln Tyr Cys  Asp Met Cys 
    1070                 1075                 1080             


Lys Ala  Leu Leu Glu Ile Lys  Asn Ser Ser Arg Leu  Asn Asn Val 
    1085                 1090                 1095             


Ile Ile  Ser Leu 
    1100         


<210>  937
<211>  1102
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  937

Met Arg Val Ser Lys Val Lys Val Asp Asn Lys Asn Met Val Leu Met 
1               5                   10                  15      


Arg Arg Thr Thr Gly Asn Gly Ala Leu Val Tyr Glu Gly Glu Thr Ser 
            20                  25                  30          


Asn Arg Thr Ile Glu Ile Leu Pro Lys Gln Lys Ile Gln Ser Phe Ser 
        35                  40                  45              


Leu Ser Ile Glu Asn Lys Thr Leu Ile Lys Arg Asp Ser Leu Lys Gly 
    50                  55                  60                  


Thr Val Gln Lys Asn Lys Tyr Asp Val Ile Arg Ala Ile Ile Lys Tyr 
65                  70                  75                  80  


Asn Arg Phe Pro Asp Arg Ile Ser Ala Glu Glu Val Leu Pro Phe Leu 
                85                  90                  95      


Asn His Lys Phe Gln Asn Glu Ile Lys Tyr Tyr Asn Asp Asn Lys Leu 
            100                 105                 110         


His Ser Phe Leu Leu Thr Ser Leu Ile Val Glu Ala Val Lys Glu Lys 
        115                 120                 125             


Asn Pro Gln Lys Leu Gln Pro Tyr Phe Asp Trp Glu Glu Trp Tyr Ile 
    130                 135                 140                 


Ser Asn Lys Ser Asn Ala Leu Ile Lys Ser Ile Glu Asn Asn Lys Ile 
145                 150                 155                 160 


Asp Ser Glu Lys Lys Asp Ser Lys Arg Lys Lys Thr Leu Gln Thr Trp 
                165                 170                 175     


Ala Ala Glu Tyr Thr Asp Asn Gly Ser Ile Asp Leu Ser Glu Tyr His 
            180                 185                 190         


Asn Ile Tyr Asp Ile Asp Thr Leu Val Arg Ala Leu Ile Lys Ala Asp 
        195                 200                 205             


Lys Gly Glu Leu Lys Glu Asp Gly Thr Pro Lys Asn Ala Asn Ala Phe 
    210                 215                 220                 


His Arg Asn Leu Lys Arg Thr Leu Gln Asp His Gln Lys Thr Val Phe 
225                 230                 235                 240 


Gly Thr Arg Glu Ala Ser Asn Met Thr Asn Arg Glu Asn Asp Gln Leu 
                245                 250                 255     


Ala Val Tyr His Leu Glu Val Val Lys Tyr Leu Glu His Tyr Phe Ser 
            260                 265                 270         


Val Lys Ser Thr Gln Arg Arg Asn Thr Arg Ala Asp Ile Asp Tyr Tyr 
        275                 280                 285             


Leu Lys Ala Glu Thr Ile Lys Asn Ile Ile Thr Lys Gln Leu Leu Asn 
    290                 295                 300                 


Ala Val Arg Asn Tyr Leu Leu Gln Gln Gly Lys Ala Gln His His Lys 
305                 310                 315                 320 


Phe Ala Glu Ile Lys Pro Asp Ser Asn Ser Leu Thr Glu Ile Lys Arg 
                325                 330                 335     


Asn Glu Ala Phe Val Leu Asn Met Ile Asp Ala Cys Gly Phe Ala Ala 
            340                 345                 350         


Asn Asn Ile Arg Asn Ile Val Asp Ala Glu Gln Ile Asn Asp Ile Leu 
        355                 360                 365             


Ser Lys Lys Glu Tyr Val Gln Ser Leu Asp Ser Asn Arg Val Asn Asn 
    370                 375                 380                 


Gln Leu Phe Lys Phe Phe Phe Gly Thr Asp Leu Pro Glu Thr Ala Thr 
385                 390                 395                 400 


Asp Lys Val Lys Thr Leu Trp Ala Met Arg Gly Ala Val Gln Gln Ile 
                405                 410                 415     


Arg Asn Lys Val Val His Tyr Lys Gln Lys Ala Leu Asp Ala Ile Phe 
            420                 425                 430         


Asn Val Thr Asp Phe Glu Tyr Pro Ser Phe Asn Asn Ser Ile Tyr Thr 
        435                 440                 445             


Asp Thr Ile Tyr Lys Asp Cys Leu Glu Thr Glu Leu Gln Lys Leu Pro 
    450                 455                 460                 


Glu Ala Phe Ala Gln Gln Leu Lys Thr Gly Gly Ala Leu Thr Tyr Tyr 
465                 470                 475                 480 


Pro Phe Asp Asp Leu Lys Thr Leu Leu Asn Lys Val Ala Phe Ser Leu 
                485                 490                 495     


Cys Arg Ser Val Val Pro Phe Ala Pro Gly Phe Lys Lys Val Gln Lys 
            500                 505                 510         


Gln Gly Gln Asn Tyr Gln Asn Ala His Lys Glu Asn Phe Tyr Asn Leu 
        515                 520                 525             


Asp Leu Lys Ser Tyr Leu Pro Lys Glu Lys Phe Asp Glu Glu Ala Tyr 
    530                 535                 540                 


Asn Ala Arg Tyr Phe Leu Leu Lys Leu Ile Tyr Asn Asn Leu Phe Leu 
545                 550                 555                 560 


Ser Asp Phe Thr Gly Asn Arg Glu Gln Phe Ser Ala Thr Val Asn Tyr 
                565                 570                 575     


Ile Leu Lys Arg Asn Lys Lys Gln Ala Glu Asn Ser Arg Arg Pro Lys 
            580                 585                 590         


Ala Tyr Ala Phe Glu Ala Val Arg Gln Met Lys Lys Glu Glu Ser Ile 
        595                 600                 605             


Thr Ser Tyr Met Ala Tyr Ala Gln Asn Gln Leu Met Val Glu Lys Asn 
    610                 615                 620                 


Lys Lys Glu Asp Asp Lys Pro Glu Asp Ile Arg Ile Asn Phe Glu Lys 
625                 630                 635                 640 


Phe Val Leu Gln Val Phe Ile Lys Gly Phe Asp Asp Phe Leu Leu Asn 
                645                 650                 655     


Glu Lys Phe Lys Phe Ile Ala Thr Pro Cys Phe Gln Leu Ser Lys Glu 
            660                 665                 670         


Asn Thr Lys Gln Gln Gln Ala Asp Val Leu Asn Gln Phe Glu Gln Arg 
        675                 680                 685             


Ile Ile Lys Glu Cys Arg Phe Gln Ser His Thr Ile Lys Ala Glu Glu 
    690                 695                 700                 


Ala Lys His Val Ala Phe Phe Thr Phe Cys Lys Leu Leu Asp Ala Thr 
705                 710                 715                 720 


His Leu Ser Asn Leu Arg Asn Glu Leu Ile Lys Phe Lys Gln Ser Ser 
                725                 730                 735     


Lys Gln Phe Glu Leu Cys His Val Leu Glu Ile Ile Glu Leu Ser Leu 
            740                 745                 750         


Leu Asn Ala Asp Val Val Pro Ala Asp Tyr Arg Glu Leu Tyr Ala Asn 
        755                 760                 765             


Lys Val Thr Cys Leu Asn Arg Val Arg Pro Phe Ile Ala Asp Gly Val 
    770                 775                 780                 


Asp Ile Thr Lys Trp Ser Gly Leu Phe Ile Gln Thr Asp Asn Glu Thr 
785                 790                 795                 800 


Pro Val Ile His Ala Asn Val Glu Leu Thr Val Lys Tyr Gly Thr Thr 
                805                 810                 815     


Lys Leu Leu Glu Gln Leu Ile Ala Lys Gly Ala Ser Phe Lys Leu Ser 
            820                 825                 830         


Glu Ser Asp Phe Asn Leu Trp Asn Ser Ala Lys Asp Thr Ile Lys Glu 
        835                 840                 845             


Val Ile Asn Lys Arg Leu Ser Leu His Lys Gln Trp Glu Asp Ala Ile 
    850                 855                 860                 


Arg Lys Asp Lys Glu Glu Lys Asn Lys Arg Val Lys Thr Arg Ser Asn 
865                 870                 875                 880 


Phe Ala Gln Gln Phe Ile Asn Lys Glu Arg Asp Ser Tyr Phe Asp Leu 
                885                 890                 895     


Cys Asp Tyr Ile Asp Ala Tyr Asn Trp Tyr Asp Ser Lys Leu His Phe 
            900                 905                 910         


Val Asn Leu Ile Arg Leu His His Leu Thr Ile Asp Ile Leu Gly Arg 
        915                 920                 925             


Met Val Gly Phe Val Ala Ile Trp Glu Arg Asp Phe Gln Tyr Met Thr 
    930                 935                 940                 


Glu Ser Ile Ser Pro Met Asn Ser Ser Lys Glu Leu Asp Phe Thr Lys 
945                 950                 955                 960 


Gly Phe Pro Leu Leu Lys Gly Ile Gln Leu Asp Tyr Tyr Lys Arg Ile 
                965                 970                 975     


Phe Leu Ser Gly Asn Tyr Arg Asp Ile Arg Asn Tyr Ile Ala His Phe 
            980                 985                 990         


Asn Tyr Leu Thr Asp Ser Lys Phe  Ser Met Ile Asp Leu  Ile Asn Glu 
        995                 1000                 1005             


Leu Arg  Glu Leu Leu Ser Tyr  Asp Arg Lys Leu Lys  Asn Ala Val 
    1010                 1015                 1020             


Asn Lys  Ala Phe Ile Asp Leu  Phe Asp Lys Gln Gly  Met Val Leu 
    1025                 1030                 1035             


Lys Leu  Lys Leu Asn Asp Ala  His Arg Phe Glu Ile  Glu Ser Val 
    1040                 1045                 1050             


Glu Pro  Lys Leu Leu Tyr His  Leu Gly Thr Thr Pro  Ala Arg Asp 
    1055                 1060                 1065             


Pro Ile  Ser Thr Tyr Gln Val  Lys Pro Gln Tyr Cys  Asp Met Cys 
    1070                 1075                 1080             


Lys Ala  Leu Leu Glu Ile Lys  Asn Ser Ser Arg Leu  Asn Asn Val 
    1085                 1090                 1095             


Ile Ile  Ser Leu 
    1100         


<210>  938
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  938

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  939
<211>  1053
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  939

Met Lys Val Ser Lys Val Asn His Arg Arg Ala Ala Val Ala Val Asn 
1               5                   10                  15      


Lys Lys Ser Val Thr Val Asn Gly Ile Leu Tyr Asp Ala Pro Val Lys 
            20                  25                  30          


Lys Asn Val Lys Thr Gly Asn Met Ser Ala Tyr Val Ser Ser Lys Tyr 
        35                  40                  45              


Val Ile Asp Asn Val Val Lys Asn Ser Ser Arg Leu Tyr Ser Pro Phe 
    50                  55                  60                  


Ser Ser Lys Arg Ile Val Ile Asp Arg Glu Lys Ile Arg Ile Ala Asp 
65                  70                  75                  80  


Arg Leu Lys Gln Cys Tyr Val Asn Phe Val Lys Tyr Tyr Leu Ser Asn 
                85                  90                  95      


Gly Ser Leu Asn Glu Gln Gln Met Arg Phe Asn Pro Asn Asn Thr Tyr 
            100                 105                 110         


Met Ala Asp Ser Arg Val His Phe Cys Val Pro Ser Gly Ile Asp Ile 
        115                 120                 125             


Glu Ser Leu Ile Asn Ser Ile Val Asp Ser Ser Leu Arg Lys Ser Leu 
    130                 135                 140                 


Lys Arg Thr Tyr Arg Phe Glu Thr Asn Tyr Gly Glu Lys Asn Thr Phe 
145                 150                 155                 160 


Asn Leu Pro Asp Leu Val Lys Lys Ser Ile Lys Ile Tyr Cys Thr Asp 
                165                 170                 175     


Glu Lys Arg Lys Leu Asn Asp Arg Glu Glu Gln Glu Met Tyr Val Leu 
            180                 185                 190         


Phe Ser Tyr Met Tyr Glu Asp Lys Tyr Lys Asp Arg Gln Lys Val Leu 
        195                 200                 205             


Ile Ala Asn Ser Ile Ser Asn Gln Ala Thr Lys Val Lys Val Cys Asp 
    210                 215                 220                 


Asp Glu Ser Arg Leu Ile Lys Leu Ser Ile Ala Asp Thr Lys Lys Lys 
225                 230                 235                 240 


Pro Leu Trp Asp Phe Ile Val Asp Tyr Ala Asn Ser Asp Lys Asn Gly 
                245                 250                 255     


Gln Tyr Thr Ile Leu Arg Asn Ile Arg Lys Ser Ile Val Leu Phe Val 
            260                 265                 270         


Cys Gly Val Asp Val Tyr Arg Asn Ile Glu Asn Asn Asp Asn Leu Asp 
        275                 280                 285             


Ile Trp Lys Trp Glu Glu Tyr Gly Ile Gln Glu Ser Gln Leu Phe Val 
    290                 295                 300                 


Lys Ile Glu Asn Cys Tyr Thr Thr Lys Gly Glu Asp Ile Ala Leu Asn 
305                 310                 315                 320 


Glu Ile Arg Asn Val Asn Leu Asp His Tyr Met Lys Ala Ile Gly Val 
                325                 330                 335     


Leu Asp Asp Glu Arg Ser Lys Phe Trp Phe Gln His Tyr Glu Asn Thr 
            340                 345                 350         


Ile Glu Ala Leu Phe Ser Lys Lys Ser Lys Arg Lys Ile Glu Arg Ile 
        355                 360                 365             


Lys Thr Ala Tyr Leu Cys Glu Tyr Leu Trp Lys Asn Phe Cys Ser Tyr 
    370                 375                 380                 


Val Ala Leu Lys Tyr Val Asp Leu Gly Lys Gly Val Tyr His Phe Thr 
385                 390                 395                 400 


Met Ser Asp Lys Leu Ser Leu Met Asn Lys Asn Thr Asn Glu Asn Gly 
                405                 410                 415     


Ile Lys Phe Gly Glu Val Asp Ser Arg Phe Asn Lys Gly Ile Ser Ser 
            420                 425                 430         


Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Thr Ile Asp Arg Asn Ile 
        435                 440                 445             


Ser Thr Tyr Thr Thr Phe Ala Thr Asn Ile Phe Ala Lys Ser Val Ile 
    450                 455                 460                 


Lys Asp Ser Tyr Arg Gln Lys Lys Ala Gly Asn Ser Asp Ala Leu Gln 
465                 470                 475                 480 


Tyr Asp Asp Glu Thr Tyr Tyr Asn Arg Lys Ala Met Asn Pro Tyr Ala 
                485                 490                 495     


Leu Lys Arg Val Leu Arg Tyr Trp Gly Gly Gln Ser Arg Trp Lys Ser 
            500                 505                 510         


Glu Leu Glu Glu Leu Asn Val Ala Glu Leu Cys Ile Asp Ile Lys Asn 
        515                 520                 525             


Arg Leu Ser Lys Ile Arg Asn Ser Gly Val His Tyr Thr Ser Thr Ser 
    530                 535                 540                 


Ala Leu Lys Gly Asn Asp Asp Asp Ser Ile Val Gly Met Leu Ile Lys 
545                 550                 555                 560 


Lys Asp Phe Asp Asp Ile Lys Asp Val Tyr Ala Ser Lys Tyr Tyr Ser 
                565                 570                 575     


Asn Asn Val Trp Met Phe Tyr Asn Thr Asp Lys Ile Ser Lys Met Met 
            580                 585                 590         


Glu Tyr Leu Tyr Gln Asp Asp Ser Asn Ile Arg Asp Ala Gln Ile Pro 
        595                 600                 605             


Ala Phe Asn Ser Val Ile Lys Arg Lys Asp Met Ala Glu Val Ile Glu 
    610                 615                 620                 


Lys Ile Val Lys Lys Asn Ser Tyr Lys Thr Ile Lys Glu Pro Tyr Gln 
625                 630                 635                 640 


Arg Glu Lys Tyr Arg Ser Cys Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
                645                 650                 655     


Tyr Asn Arg Phe Ile Lys Gln Asp Asn Leu Lys Asp Gln Val Ile Gln 
            660                 665                 670         


Ile Ile Asp Ser Asn Thr Glu Leu Ile Gly Asp Asn Ser Arg Ala Val 
        675                 680                 685             


Asp Asn Leu Lys Lys Arg Ile His Asp Val Asp Ser Gln Thr Met Ser 
    690                 695                 700                 


Phe Gly Glu Leu Cys Gln Val Ile Met Thr Asp Tyr Asn Met Gln Asn 
705                 710                 715                 720 


Gln Glu Asn Lys Ser Ile Lys Ser Lys Glu Arg Gln Asp Lys Asp Arg 
                725                 730                 735     


Lys Asn Gly Ile Asp Asn Ser Tyr Lys His Phe Pro Leu Leu Leu His 
            740                 745                 750         


His Leu Ile Lys Val Ser Phe Leu Lys Phe Ile Lys Thr Asp Glu Lys 
        755                 760                 765             


Leu Ala Phe Ile Arg Glu Pro Arg Ile Thr Glu Trp Asp Lys Thr Leu 
    770                 775                 780                 


Glu Gln Phe Glu Ala Gln Ile Gln Thr Val Asp Ile Tyr Asn Ser Leu 
785                 790                 795                 800 


Lys Met Met Val Ala Glu Asn Lys Ser Leu Leu Asp Trp Tyr Thr Leu 
                805                 810                 815     


Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asp Val 
            820                 825                 830         


Lys Asn Tyr Ile Gln Tyr Leu Ser Asn Ile Asp Lys Arg Ala Gly Ser 
        835                 840                 845             


Val Lys Asn Asn Lys Ser Ala Ser Thr Glu Val Lys Ile Arg Gln Tyr 
    850                 855                 860                 


Ser Glu Ile Val Arg Ile Leu Asp Phe Ser Leu Gln Tyr Ile Gly Arg 
865                 870                 875                 880 


Val Ser Asn Asp Val Thr Asp Tyr Phe Val Asp Glu Asp Glu Tyr Ala 
                885                 890                 895     


Ala Phe Leu Ser Lys Tyr Val Glu Phe Ser Gly Asn Asp Ile Val Ser 
            900                 905                 910         


Met Lys Ala Phe Cys Gln Ser Arg Thr Ala Asn Gly Lys His Thr Ile 
        915                 920                 925             


Gly Leu Tyr Cys Asp Gly Ala Asn Pro Ile Met Asn Arg Asn Ile Ala 
    930                 935                 940                 


Tyr Ala Lys Met Tyr Gly Asn Asp Glu Ile Leu Ser Tyr Ile Tyr Asn 
945                 950                 955                 960 


Lys Val Thr Lys Lys Asp Ile Glu Lys Tyr Tyr Val Ser Gln Asp Asn 
                965                 970                 975     


Leu Glu Lys Val Phe Ala Asp Gly Lys Cys Gln Asp Val Gln Gln Gln 
            980                 985                 990         


Asn Ala Leu Cys Asp Phe Gln Lys  Met Lys Asn His Ile  Glu Leu Thr 
        995                 1000                 1005             


Glu Val  Ser Ile Tyr Thr Asp  Ile Leu Asn Asp Phe  Met Ala Gln 
    1010                 1015                 1020             


Phe Ile  Ser Trp Ala Tyr Leu  Arg Glu Arg Asp Leu  Met Tyr Phe 
    1025                 1030                 1035             


Gln Leu  Gly Leu Asn Tyr Ile  Arg Cys Phe Met Val  His Met Asn 
    1040                 1045                 1050             


<210>  940
<211>  1102
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  940

Met Arg Val Ser Lys Val Lys Val Asp Asn Lys Asn Met Val Leu Met 
1               5                   10                  15      


Arg Arg Thr Thr Gly Asn Gly Ala Leu Val Tyr Glu Gly Glu Thr Ser 
            20                  25                  30          


Asn Arg Thr Ile Glu Ile Leu Pro Lys Gln Lys Ile Gln Ser Phe Ser 
        35                  40                  45              


Leu Ser Ile Glu Asn Lys Thr Leu Ile Lys Arg Asp Ser Leu Lys Gly 
    50                  55                  60                  


Thr Val Gln Lys Asn Lys Tyr Asp Val Ile Arg Ala Ile Ile Lys Tyr 
65                  70                  75                  80  


Asn Arg Phe Pro Asp Arg Ile Ser Ala Glu Glu Val Leu Pro Phe Leu 
                85                  90                  95      


Asn His Lys Phe Gln Asn Glu Ile Lys Tyr Tyr Asn Asp Asn Lys Leu 
            100                 105                 110         


His Ser Phe Leu Leu Thr Ser Leu Ile Val Glu Ala Val Lys Glu Lys 
        115                 120                 125             


Asn Pro Gln Lys Leu Gln Pro Tyr Phe Asp Trp Glu Glu Trp Tyr Ile 
    130                 135                 140                 


Ser Asn Lys Ser Asn Ala Leu Ile Lys Ser Ile Glu Asn Asn Lys Ile 
145                 150                 155                 160 


Asp Ser Glu Lys Lys Asp Ser Lys Arg Lys Lys Thr Leu Gln Thr Trp 
                165                 170                 175     


Ala Ala Glu Tyr Thr Asp Asn Gly Ser Ile Asp Leu Ser Glu Tyr His 
            180                 185                 190         


Asn Ile Tyr Asp Ile Asp Thr Leu Val Arg Ala Leu Ile Lys Ala Asp 
        195                 200                 205             


Lys Gly Glu Leu Lys Glu Asp Gly Thr Pro Lys Asn Ala Asn Ala Phe 
    210                 215                 220                 


His Arg Asn Leu Lys Arg Thr Leu Gln Asp His Gln Lys Thr Val Phe 
225                 230                 235                 240 


Gly Thr Arg Glu Ala Ser Asn Met Thr Asn Arg Glu Asn Asp Gln Leu 
                245                 250                 255     


Ala Val Tyr His Leu Glu Val Val Lys Tyr Leu Glu His Tyr Phe Ser 
            260                 265                 270         


Val Lys Ser Thr Gln Arg Arg Asn Thr Arg Ala Asp Ile Asp Tyr Tyr 
        275                 280                 285             


Leu Lys Ala Glu Thr Ile Lys Asn Ile Ile Thr Lys Gln Leu Leu Asn 
    290                 295                 300                 


Ala Val Arg Asn Tyr Leu Leu Gln Gln Gly Lys Ala Gln His His Lys 
305                 310                 315                 320 


Phe Ala Glu Ile Lys Pro Asp Ser Asn Ser Leu Thr Glu Ile Lys Arg 
                325                 330                 335     


Asn Glu Ala Phe Val Leu Asn Met Ile Asp Ala Cys Gly Phe Ala Ala 
            340                 345                 350         


Asn Asn Ile Arg Asn Ile Val Asp Ala Glu Gln Ile Asn Asp Ile Leu 
        355                 360                 365             


Ser Lys Lys Glu Tyr Val Gln Ser Leu Asp Ser Asn Arg Val Asn Asn 
    370                 375                 380                 


Gln Leu Phe Lys Phe Phe Phe Gly Thr Asp Leu Pro Glu Thr Ala Thr 
385                 390                 395                 400 


Asp Lys Val Lys Thr Leu Trp Ala Met Arg Gly Ala Val Gln Gln Ile 
                405                 410                 415     


Arg Asn Lys Val Val His Tyr Lys Gln Lys Ala Leu Asp Ala Ile Phe 
            420                 425                 430         


Asn Val Thr Asp Phe Glu Tyr Pro Ser Phe Asn Asn Ser Ile Tyr Thr 
        435                 440                 445             


Asp Thr Ile Tyr Lys Asp Cys Leu Glu Thr Glu Leu Gln Lys Leu Pro 
    450                 455                 460                 


Glu Ala Phe Ala Gln Gln Leu Lys Thr Gly Gly Ala Leu Thr Tyr Tyr 
465                 470                 475                 480 


Pro Phe Asp Asp Leu Lys Thr Leu Leu Asn Lys Val Ala Phe Ser Leu 
                485                 490                 495     


Cys Arg Ser Val Val Pro Phe Ala Pro Gly Phe Lys Lys Val Gln Lys 
            500                 505                 510         


Gln Gly Gln Asn Tyr Gln Asn Ala His Lys Glu Asn Phe Tyr Asn Leu 
        515                 520                 525             


Asp Leu Lys Ser Tyr Leu Pro Lys Glu Lys Phe Asp Glu Glu Ala Tyr 
    530                 535                 540                 


Asn Ala Arg Tyr Phe Leu Leu Lys Leu Ile Tyr Asn Asn Leu Phe Leu 
545                 550                 555                 560 


Ser Asp Phe Thr Gly Asn Arg Glu Gln Phe Ser Ala Thr Val Asn Tyr 
                565                 570                 575     


Ile Leu Lys Arg Asn Lys Lys Gln Ala Glu Asn Ser Arg Arg Pro Lys 
            580                 585                 590         


Ala Tyr Ala Phe Glu Ala Val Arg Gln Met Lys Lys Glu Glu Ser Ile 
        595                 600                 605             


Thr Ser Tyr Met Ala Tyr Ala Gln Asn Gln Leu Met Val Glu Lys Asn 
    610                 615                 620                 


Lys Lys Glu Asp Asp Lys Pro Glu Asp Ile Arg Ile Asn Phe Glu Lys 
625                 630                 635                 640 


Phe Val Leu Gln Val Phe Ile Lys Gly Phe Asp Asp Phe Leu Leu Asn 
                645                 650                 655     


Glu Lys Phe Lys Phe Ile Ala Thr Pro Cys Phe Gln Leu Ser Lys Glu 
            660                 665                 670         


Asn Thr Lys Gln Gln Gln Ala Asp Val Leu Asn Gln Phe Glu Gln Arg 
        675                 680                 685             


Ile Ile Lys Glu Cys Arg Phe Gln Ser His Thr Ile Lys Ala Glu Glu 
    690                 695                 700                 


Ala Lys His Val Ala Phe Phe Thr Phe Cys Lys Leu Leu Asp Ala Thr 
705                 710                 715                 720 


His Leu Ser Asn Leu Arg Asn Glu Leu Ile Lys Phe Lys Gln Ser Ser 
                725                 730                 735     


Lys Gln Phe Glu Leu Cys His Val Leu Glu Ile Ile Glu Leu Ser Leu 
            740                 745                 750         


Leu Asn Ala Asp Val Val Pro Ala Asp Tyr Arg Glu Leu Tyr Ala Asn 
        755                 760                 765             


Lys Val Thr Cys Leu Asn Arg Val Arg Pro Phe Ile Ala Asp Gly Val 
    770                 775                 780                 


Asp Ile Thr Lys Trp Ser Gly Leu Phe Ile Gln Thr Asp Asn Glu Thr 
785                 790                 795                 800 


Pro Val Ile His Ala Asn Val Glu Leu Thr Val Lys Tyr Gly Thr Thr 
                805                 810                 815     


Lys Leu Leu Glu Gln Leu Ile Ala Lys Gly Ala Ser Phe Lys Leu Ser 
            820                 825                 830         


Glu Ser Asp Phe Asn Leu Trp Asn Ser Ala Lys Asp Thr Ile Lys Glu 
        835                 840                 845             


Val Ile Asn Lys Arg Leu Ser Leu His Lys Gln Trp Glu Asp Ala Ile 
    850                 855                 860                 


Arg Lys Asp Lys Glu Glu Lys Asn Lys Arg Val Lys Thr Arg Ser Asn 
865                 870                 875                 880 


Phe Ala Gln Gln Phe Ile Asn Lys Glu Arg Asp Ser Tyr Phe Asp Leu 
                885                 890                 895     


Cys Asp Tyr Ile Asp Ala Tyr Asn Trp Tyr Asp Ser Lys Leu His Phe 
            900                 905                 910         


Val Asn Leu Ile Arg Leu His His Leu Thr Ile Asp Ile Leu Gly Arg 
        915                 920                 925             


Met Val Gly Phe Val Ala Ile Trp Glu Arg Asp Phe Gln Tyr Met Thr 
    930                 935                 940                 


Glu Ser Ile Ser Pro Met Asn Ser Ser Lys Glu Leu Asp Phe Thr Lys 
945                 950                 955                 960 


Gly Phe Pro Leu Leu Lys Gly Ile Gln Leu Asp Tyr Tyr Lys Arg Ile 
                965                 970                 975     


Phe Leu Ser Gly Asn Tyr Arg Asp Ile Arg Asn Tyr Ile Ala His Phe 
            980                 985                 990         


Asn Tyr Leu Thr Asp Ser Lys Phe  Ser Met Ile Asp Leu  Ile Asn Glu 
        995                 1000                 1005             


Leu Arg  Glu Leu Leu Ser Tyr  Asp Arg Lys Leu Lys  Asn Ala Val 
    1010                 1015                 1020             


Asn Lys  Ala Phe Ile Asp Leu  Phe Asp Lys Gln Gly  Met Val Leu 
    1025                 1030                 1035             


Lys Leu  Lys Leu Asn Asp Ala  His Arg Phe Glu Ile  Glu Ser Val 
    1040                 1045                 1050             


Glu Pro  Lys Leu Leu Tyr His  Leu Gly Thr Thr Pro  Ala Arg Asp 
    1055                 1060                 1065             


Pro Ile  Ser Thr Tyr Gln Val  Lys Pro Gln Tyr Cys  Asp Met Cys 
    1070                 1075                 1080             


Lys Ala  Leu Leu Glu Ile Lys  Asn Ser Ser Arg Leu  Asn Asn Val 
    1085                 1090                 1095             


Ile Ile  Ser Leu 
    1100         


<210>  941
<211>  1188
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  941

Leu Ser Cys Ala Ile Lys Lys Thr Leu Arg Lys Glu Val Lys Leu Glu 
1               5                   10                  15      


Asn Gly Cys Arg Met Gln Met Thr Glu Ile Thr Ile Ser Leu Met Ser 
            20                  25                  30          


Ala Ile Cys Leu Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu 
        35                  40                  45              


Lys Ala Phe Phe Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr 
    50                  55                  60                  


Val Glu Gln Ile Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys 
65                  70                  75                  80  


Val Val Glu Lys Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp 
                85                  90                  95      


His Arg Lys Lys Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala 
            100                 105                 110         


Ala Asp Glu Lys Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu 
        115                 120                 125             


Ile Gly Leu Tyr Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn 
    130                 135                 140                 


Cys Phe Ser Asp Met Ile Glu Ser His Asn Cys Ile Cys Gly Lys Ile 
145                 150                 155                 160 


Glu Glu Ile Leu Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Gln 
                165                 170                 175     


Lys Lys Glu Lys Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys 
            180                 185                 190         


Tyr Arg Ala Ala Val Asn Tyr Leu Ala Asp Glu Val Arg Lys Thr Val 
        195                 200                 205             


Leu Gly Glu Ile Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr 
    210                 215                 220                 


Trp Ile Glu Tyr Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser 
225                 230                 235                 240 


Arg Asn Lys Glu Arg Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His 
                245                 250                 255     


Ile Trp Lys Glu Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met 
            260                 265                 270         


Gly Lys Gly Val Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Ala Leu 
        275                 280                 285             


Glu Gly Gly Ser Val Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn 
    290                 295                 300                 


Gly Val Ser Gly Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu 
305                 310                 315                 320 


Glu Arg Glu Met Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala 
                325                 330                 335     


Arg Ala Val Thr Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp 
            340                 345                 350         


Val Leu Leu Met Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys 
        355                 360                 365             


Glu Glu Arg Gln Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr 
    370                 375                 380                 


Leu Tyr Ala Asp Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln 
385                 390                 395                 400 


Ser Arg Phe Arg Glu Lys Gly Asp Ser Leu Val Asn Leu Tyr Ser Gly 
                405                 410                 415     


Glu Asp Leu Tyr Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn 
            420                 425                 430         


Ile Thr Phe His Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys 
        435                 440                 445             


His Asp Leu Ala Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr 
    450                 455                 460                 


Glu Leu Phe Arg Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr 
465                 470                 475                 480 


Asp Ala Glu Val Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg 
                485                 490                 495     


Lys Tyr Arg Ala Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg 
            500                 505                 510         


Pro Glu Leu Pro Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu 
        515                 520                 525             


Arg Arg Leu Met Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp 
    530                 535                 540                 


Ser Ala Leu Phe Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu 
545                 550                 555                 560 


Gln Glu Gln Lys Arg Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg 
                565                 570                 575     


Ala Ile Lys Lys Leu Ser Gly Gln Glu Lys Gly Asp Lys Glu Gln Lys 
            580                 585                 590         


Ala Trp Glu Ser Phe Glu Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg 
        595                 600                 605             


Ser Phe Gly Ala Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln 
    610                 615                 620                 


Asn Ser Asp Ile Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala 
625                 630                 635                 640 


Asn Asn Lys Lys Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn 
                645                 650                 655     


Cys Ile Ser Glu Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Lys Glu 
            660                 665                 670         


Leu Arg Thr Pro Val Leu Thr Ala Lys Glu Trp Ser Lys Glu Glu Phe 
        675                 680                 685             


Cys Arg Ala Asp Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys 
    690                 695                 700                 


Glu Thr Phe Asn Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala 
705                 710                 715                 720 


His Phe Ile Asn Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg 
                725                 730                 735     


Asn Tyr Leu Gln Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu 
            740                 745                 750         


Gly Asp Cys Val Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg 
        755                 760                 765             


Asn Thr Val Glu Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr 
    770                 775                 780                 


Thr Asn Val Met Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu 
785                 790                 795                 800 


Tyr Leu Ser Gly Phe Val Asp Tyr Asn Ile Thr Lys Lys Glu Thr Asp 
                805                 810                 815     


Ile Glu Lys Ala Leu Tyr Ser Phe Cys Lys Gln Lys Phe Lys Val Asp 
            820                 825                 830         


Gly Lys Glu Tyr Met Ala Gly Ile Tyr Tyr Asp Gly Glu Asn Leu Ile 
        835                 840                 845             


Pro Asn Arg Asn Ile Ile Arg Ala Asn Met Tyr Gly Asn Thr Ser Cys 
    850                 855                 860                 


Leu Lys Pro Cys Met Asp Arg Ile Thr Leu Lys Glu Ile Arg Thr Met 
865                 870                 875                 880 


Tyr Ala Asp Gln Asn Lys Leu Asp Leu Val Leu Lys Glu Gly Val Cys 
                885                 890                 895     


His Thr Glu Glu Glu Gln Lys Ala Tyr Arg Glu Tyr Gln Asn Glu Lys 
            900                 905                 910         


Asn Arg Ile Glu Leu Phe Asp Val Cys Thr Tyr Thr Gln Ile Leu Asn 
        915                 920                 925             


Asp Met Gln Ala Arg Leu Ile Gly Trp Ser Tyr Met Arg Glu Arg Asp 
    930                 935                 940                 


Leu Met Tyr Tyr Gln Leu Gly Tyr Tyr Tyr Thr Lys Leu Phe Trp Thr 
945                 950                 955                 960 


Asp Ser Ile Ser Glu Glu Asp Ala Arg Arg Arg Leu Val Gly Asn Leu 
                965                 970                 975     


Val Asn Val Glu Asp Gly Ala Ile Leu Tyr Gln Ile Leu Ala Phe Asn 
            980                 985                 990         


Ser Tyr Asn Leu Pro Ile Ile Ala  Asn Lys Asn Asn Thr  Val Thr Leu 
        995                 1000                 1005             


Leu Lys  Asp Glu Gly Ser Ile  Gly Gly Lys Ala Ile  Thr Ala Phe 
    1010                 1015                 1020             


Phe Lys  Asn Tyr Glu Asn Ala  Glu Met Ile Tyr Glu  Glu Ala Leu 
    1025                 1030                 1035             


Asp Leu  Phe Glu Asn Met Asp  Glu His Ala Ala Ile  Ile Asn Thr 
    1040                 1045                 1050             


Arg Asn  Tyr Ile Glu His Phe  Lys Tyr Phe Ile Lys  Ser Asp Arg 
    1055                 1060                 1065             


Ser Met  Met Asp Leu Tyr Ser  Glu Ile Tyr Asp Arg  Phe Phe Arg 
    1070                 1075                 1080             


His Asp  His Asn Arg Lys Lys  Asn Val Pro Asp Ser  Leu Lys Asn 
    1085                 1090                 1095             


Val Leu  Ala Asp Asn Phe Met  Ile Val Asp Ile Asp  Met Glu Leu 
    1100                 1105                 1110             


Gly Ser  Lys Lys Val Gly Glu  Lys Lys Lys Gly Phe  Arg Glu Tyr 
    1115                 1120                 1125             


Lys Ala  Ala Arg Ile Glu Phe  Thr Asp Ser Gly Ile  Arg Ser Thr 
    1130                 1135                 1140             


Asp Met  Thr Tyr Thr Ile Lys  Pro Asp Ile Lys Asp  Asn Lys Lys 
    1145                 1150                 1155             


Asp Glu  Lys Val Leu Val Pro  Ala Arg Ser Glu Val  Phe Leu Lys 
    1160                 1165                 1170             


Gln Phe  Arg Lys Ile Leu Glu  Tyr Arg Ile Gln Asp  Lys Thr Gln 
    1175                 1180                 1185             


<210>  942
<211>  1394
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  942

Met Arg Ile Leu Gln Ser Lys Gly Arg Ser Phe Thr Thr Phe Ser Ala 
1               5                   10                  15      


Glu Ser Ile Gly Met Thr Arg Gly Leu Glu Pro Asp Asp Thr Gln Ser 
            20                  25                  30          


Ala Ala Lys Trp Leu Asp Glu Gly Glu Lys Arg Ile Ala Pro Val Arg 
        35                  40                  45              


Ile Pro Val Phe Leu Lys Glu Asp Pro Asp Leu Ile Ile Arg Gln Val 
    50                  55                  60                  


Val Ser Val Leu Asp Lys Val Ile Arg Lys Thr Lys Ile Leu Arg Asp 
65                  70                  75                  80  


Leu Pro Leu Gln Thr Tyr Val Asp Arg Thr Leu Leu Ala Glu Glu Leu 
                85                  90                  95      


Trp Gln Arg Ile Thr Asp Arg Ile Arg Gln Ser His Asp Gly Glu Ile 
            100                 105                 110         


Thr Pro Ala Asp Leu Asp Ala Tyr Lys Ser Arg Trp Ser Trp Lys Val 
        115                 120                 125             


His Pro Tyr Ala Lys Asn Pro Pro Asp Pro Ser Asn Pro Lys Gly Asp 
    130                 135                 140                 


Gln Asn Ala Val Leu Ile Leu Lys Asn Gly Asp Arg Leu Pro Ser Pro 
145                 150                 155                 160 


Thr Asp Ser Arg Gly Arg Trp His Gly Ala Leu Trp Lys Thr Thr Ser 
                165                 170                 175     


Asp Gly Asp Pro Asp Tyr Ala Ser Thr Ala Asn Ala Ile Ile Asn His 
            180                 185                 190         


Ile Phe Ser Asn Glu Val Leu Ile Gly Gly His Tyr Leu Ser Asp Trp 
        195                 200                 205             


Ser Gly Lys Gly Ser Lys Ser Ser Val Gly Leu Ala Glu Arg Arg Gly 
    210                 215                 220                 


Asp Ser Ile Arg Ser Ser Thr Pro Asp Leu Lys Leu Pro Ile Gly Pro 
225                 230                 235                 240 


Gly Ala Ser Ala Arg Leu Leu Leu Asp Leu Asp Asp Gln Asn Ala Lys 
                245                 250                 255     


Pro Ile Ile Lys Leu Phe Phe His Gln Asp Ile Ala Ala Lys Ile Tyr 
            260                 265                 270         


Ala Phe Val Leu Glu Arg Ala Arg Val Asp Gly Pro Arg Lys Pro Asn 
        275                 280                 285             


Val Ala Phe Ser Val Arg Ser Ser Asp Phe Gly Arg Leu Leu Ser Lys 
    290                 295                 300                 


His Phe Gly Asp Val Pro Asn His Arg Asp Phe Asp Asp Glu Thr Lys 
305                 310                 315                 320 


Ile Lys Ile Val Ala Phe Tyr Asp Arg Val Lys Arg Tyr Tyr Ala Ala 
                325                 330                 335     


Leu Ser Lys Ser Glu Ser Phe Arg Arg Ala Ile Ala Lys Ala Glu Ile 
            340                 345                 350         


Ser Lys Leu Glu Ala Ile Leu Pro Arg Asp Lys Ser His Leu Leu Ala 
        355                 360                 365             


Val Leu Ala Gly Lys Glu Arg Asn Thr Glu Ile Ser Ser Leu Ile Arg 
    370                 375                 380                 


Phe Gly Lys Leu Val Gly His Ala Cys Asp Ile Ser Pro Val Val Glu 
385                 390                 395                 400 


Val Gln Thr Ala Phe Asp Asn Asn Val Arg His Leu Ala Thr Ser Asp 
                405                 410                 415     


Gly Gln Ser Glu Ile Lys Arg Asn Glu Asn Phe Thr Arg Val Trp Arg 
            420                 425                 430         


Thr Ser Val Ala Phe Ser Leu Arg Thr Leu Asp Ser Trp Leu Lys Pro 
        435                 440                 445             


Asp Trp Pro Lys Leu Thr Glu Asp Glu Ala Arg Arg Arg Asn Asp Arg 
    450                 455                 460                 


Asn Pro Gly Gly Gln Gln Ile Asn Lys Ser Ala Leu Glu Arg Asp Ile 
465                 470                 475                 480 


Ala Gln Met Ser Tyr Ile Lys Thr Ile Ala Gly Glu Glu Pro Val Glu 
                485                 490                 495     


Gly Phe Leu Asn Gly Ala Gly Ile Ile Phe Gly Ser Lys His Val Glu 
            500                 505                 510         


Phe Glu Gly Glu Ala Ala Arg Arg Cys Glu Ile Phe Ala Gln Gly Asp 
        515                 520                 525             


Lys Ala Lys Asn Arg Glu Leu Val Trp Ala Trp Leu Arg Leu Ala Ala 
    530                 535                 540                 


Glu Met Arg His Arg Thr Asn His Phe Ser Thr Lys Pro Arg Leu Val 
545                 550                 555                 560 


Ser Leu Met Gln Lys Gly Val Leu Ser Pro Thr Arg Asp Asn Pro Gly 
                565                 570                 575     


Asn Phe Glu Asn Arg Lys Gly Asn Glu Val Gln Gln Ala Ala Leu Asp 
            580                 585                 590         


Ala Phe Gly Gln Leu Leu Ser Phe Asp Ile Asn Tyr Gln Ala Ile Leu 
        595                 600                 605             


Leu Val Asn Asp Phe Asn Arg Leu Gln Val Thr Arg Tyr Thr Ser Asp 
    610                 615                 620                 


Gly Gln Phe Lys Asp Val Leu Arg Arg Ala Leu Ser Thr Asp Asp Asp 
625                 630                 635                 640 


Pro Val Ile Thr Thr Pro Lys Phe Met Ser Val Leu Arg Lys Ala Lys 
                645                 650                 655     


Gly Ile Phe Asp His Asp Leu Glu Ser Ala Pro Glu Trp Ser Lys Phe 
            660                 665                 670         


Leu Gly Ser Leu Asp Leu Thr Ala Leu Ser Ala Ala Pro Asp Gly Pro 
        675                 680                 685             


Asn Gln Phe Lys Ile Gly Leu Leu Arg His Leu Phe Ala Thr Asp Phe 
    690                 695                 700                 


Gln Ser Trp Leu Ala Arg Lys Ala Asn Thr Lys Asp Gln Ile Gln Ala 
705                 710                 715                 720 


Ala Val Val Ala Val Ser Glu Asp Lys Asn Arg Arg Thr Leu Asp Val 
                725                 730                 735     


Leu Lys Asn Glu Glu Ser Arg Val Tyr Ala Val Ala Glu Thr Ala Ala 
            740                 745                 750         


Lys Met Leu Ile Phe Ala Lys Ala Asp Ser Phe Ser Glu Leu Ala Ala 
        755                 760                 765             


Leu Val Met Ser Met Ala Phe Ala Glu Asp Asn Thr Arg Lys Ser Tyr 
    770                 775                 780                 


Lys Pro Lys Pro Glu Glu Gln Ser Lys Arg Ser Thr Trp Val Asp Asp 
785                 790                 795                 800 


Phe Gln Arg Asp Leu Phe Val Tyr Leu Phe Asn His Tyr Leu Asn Thr 
                805                 810                 815     


Gln Ser Leu His Trp Ile Phe Asp Val Thr Asp Leu Val Gly Asp Gly 
            820                 825                 830         


Glu Ala Arg Thr Val Thr Leu Phe Asp Leu Gly Ala Gly Arg Trp Ser 
        835                 840                 845             


Leu Glu Ser Lys Pro Trp His Ser Gln Phe Tyr Ala Trp Leu Tyr Leu 
    850                 855                 860                 


Thr Pro Val Asp Glu Val Ala Leu Leu Arg Asn Gln Met Arg Arg Met 
865                 870                 875                 880 


Leu Ile Leu Glu Lys Lys Gly Gly Ser Asn Glu Thr Pro Ala Leu Arg 
                885                 890                 895     


Asp Leu Asp Arg Leu Met Thr Leu Tyr Ile Ala Val Ser Ser Ala Gly 
            900                 905                 910         


Phe Asp Gly Thr Glu His Ile Gln Thr Thr Ala Glu Asp Asp Lys Arg 
        915                 920                 925             


Phe Arg Leu Tyr Gly Gly Leu Leu Tyr Glu Asp Ala Val Gln Phe Glu 
    930                 935                 940                 


Lys Val Tyr Ser Ala Ala Ala Asp Thr Asn Asp Gln Ser Leu Pro Gly 
945                 950                 955                 960 


Thr Arg Arg Gly Leu Arg Gln Ile Ala Arg Leu Gly His Ile Ser Val 
                965                 970                 975     


Leu Lys Gly Ile Phe Glu Lys His Leu Ile Thr Pro Asp Glu Val Ser 
            980                 985                 990         


Thr Leu Ile Glu Thr Lys Lys Ala  Lys Ser Phe Lys Asp  Ala Thr Lys 
        995                 1000                 1005             


Arg Ala  Lys Leu His Asn Glu  Ile Val Thr Leu Ser  Lys Gly Phe 
    1010                 1015                 1020             


Lys Pro  Asp Ile His Gln Leu  Asp Lys Lys Cys Lys  Glu Tyr Lys 
    1025                 1030                 1035             


Asp Leu  Ser Ala Glu Ile Thr  Val His Asn Phe Lys  Ala Ala Gly 
    1040                 1045                 1050             


Ala Arg  Leu Thr Glu His Ala  Arg Leu His Gln Leu  Leu Met Arg 
    1055                 1060                 1065             


Val Ile  Ser Arg Leu Ala Asp  Phe Thr Leu Ile Trp  Glu Arg Asp 
    1070                 1075                 1080             


Arg Asn  Tyr Val Leu Leu Ala  Leu Ile Tyr Pro Lys  Leu Leu His 
    1085                 1090                 1095             


Pro Asp  Glu Asn Ala Pro Arg  Leu His Arg Arg Asp  Gly Lys Val 
    1100                 1105                 1110             


Gly Phe  Leu Leu Pro Pro Glu  Thr Thr Lys Thr Met  Arg Ala Ala 
    1115                 1120                 1125             


His Ala  Pro Leu Ser Asp Asn  Asp Lys Arg Lys Leu  Ser Arg Glu 
    1130                 1135                 1140             


Ile Ala  Leu Thr Ser Glu Asn  Val Glu Glu Gly Phe  Leu Pro Leu 
    1145                 1150                 1155             


Trp Asp  Asp Asp Met Gly Tyr  Arg Leu Thr Gly Tyr  Pro Ile His 
    1160                 1165                 1170             


Leu Ala  Leu Leu Glu Met Asp  Lys Arg Asp Ala Phe  Ala Arg Phe 
    1175                 1180                 1185             


Phe Asp  Arg Ser Glu Thr Glu  Asn Pro Leu Asp Val  Ala Glu Arg 
    1190                 1195                 1200             


Ala Arg  Ile Lys Arg Gly Thr  Gly Asn Ser Ser Pro  Leu Gln Arg 
    1205                 1210                 1215             


Arg Gln  Leu Thr Phe Lys Asp  Gly Lys Arg Arg Ile  Arg Asn Asp 
    1220                 1225                 1230             


Phe Ala  His Phe Asn Val Ile  Val Ser Asp Arg Lys  Arg Val Ser 
    1235                 1240                 1245             


Leu Thr  Tyr Leu Met Asn Ala  Val Arg Ser Leu Val  Ala Tyr Asp 
    1250                 1255                 1260             


Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ala Val Ala  Asp Ile Leu 
    1265                 1270                 1275             


Val Asp  Glu Gly Leu Asp Ile  Ser Trp Glu Met Thr  Gly Asp Arg 
    1280                 1285                 1290             


Leu Arg  Asn Pro Val Val Val  Pro Arg Leu Glu Thr  Asn Leu Lys 
    1295                 1300                 1305             


Lys Val  Arg Lys His Arg Gly  Leu Ala Asp Pro Gln  Phe Val Leu 
    1310                 1315                 1320             


Pro Leu  Ala Ser Val Arg Tyr  Thr Ser Met Val Lys  Ala Leu Phe 
    1325                 1330                 1335             


Asp Phe  Gln Ala Gly Gly Tyr  Arg Lys Glu Ile Ile  Val Gly Gln 
    1340                 1345                 1350             


Glu Thr  Lys Gln Arg Gly Glu  Leu Gly Tyr Pro Val  Glu Leu Arg 
    1355                 1360                 1365             


Val Leu  Leu Gly Ser Leu Gly  Ala Asp Met Pro Asp  Asp Val Leu 
    1370                 1375                 1380             


Gly Met  Lys Leu Tyr Val Ile  Gln Pro Gln Lys 
    1385                 1390                 


<210>  943
<211>  1330
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  943

Met Lys Arg Glu Lys Asn Ile Thr Ile Met Lys Ile Ser Lys Val Asn 
1               5                   10                  15      


His Arg Arg Thr Ala Val Ala Leu Asn Gly Asp Lys Ser Glu Leu Gly 
            20                  25                  30          


Gly Ile Leu Tyr Glu Ala Pro Val Gln Lys Asp Lys Asn Gly Asn Tyr 
        35                  40                  45              


Asn Asp Val Ile Ala Glu Thr Gly Lys Val Val Asn Glu Ala Leu Asp 
    50                  55                  60                  


Lys Lys Ser Arg Leu Tyr Thr Pro Phe Asn Asn Gln Lys Val Ile Ile 
65                  70                  75                  80  


Asp Lys Asn Leu Gln Arg Tyr Ala Asn Asn Leu Lys Arg Cys Tyr Ile 
                85                  90                  95      


Asn Phe Val Lys Gln Tyr Val Asn Asn Lys Ser Phe Asn Tyr Lys Ala 
            100                 105                 110         


Met Gln Phe Ile Pro Asp Ile Gln Asn Pro Lys Thr Asn Asp Ala Val 
        115                 120                 125             


Asn Tyr Arg Thr Asp Arg Asp Asn Val Tyr Asn Lys Asn Lys Tyr Tyr 
    130                 135                 140                 


Asp Lys Gln Thr Lys Ser Lys Ser Lys Lys Phe Ile Tyr Glu Lys Ile 
145                 150                 155                 160 


Val Ile Pro Gln Asn Glu Gln Asn Ile Val Ile Ser Ala Leu Val Asn 
                165                 170                 175     


Cys Ser Leu Arg Lys Ser Leu Arg Lys Asp Val Ser Tyr Lys Thr Lys 
            180                 185                 190         


Ser Gly Glu Ile Lys Thr Tyr Asn Leu Pro Glu Leu Val Lys Lys Ser 
        195                 200                 205             


Met Arg Phe Tyr Cys Leu Glu Gly Gln Arg Glu Pro Asp Glu Lys Glu 
    210                 215                 220                 


Lys Tyr Glu Met Tyr Ile Leu Phe Ser Tyr Met Lys Glu Asp Lys Arg 
225                 230                 235                 240 


Thr Lys Asn Thr Asp Leu Leu Val Lys Ser Ile Ser Asn Gln Asn Thr 
                245                 250                 255     


Lys Val Lys Val Glu Asp Ile Asp Gly Asn Lys Leu Leu Lys Leu Ser 
            260                 265                 270         


Ile Ala Asp Thr Lys Lys Lys Pro Leu Trp Glu Tyr Leu Ile Lys Tyr 
        275                 280                 285             


Ala Asp Ser Ser Arg Gln Arg Glu Leu Met Tyr Asp Ile Arg Lys Lys 
    290                 295                 300                 


Ile Ile Leu Tyr Val Ala Gly Ile Glu Glu Tyr Glu Asn Ile Lys Glu 
305                 310                 315                 320 


Asp Ser Gly Leu Ser Lys Val Ser Trp Ser Lys Tyr Asn Ile Ser Asp 
                325                 330                 335     


Asn Lys Met Phe Phe Asp Ile Asn Ser Cys Thr Asp Lys Arg Lys Gln 
            340                 345                 350         


Asn Leu Glu Ile Lys Ile Arg Glu Ala Asn Ile Glu His Tyr Arg Asn 
        355                 360                 365             


Ala Ser Ser Lys Leu Cys Asp Asp Glu Ser Ile Phe Trp Phe Gln His 
    370                 375                 380                 


Phe Glu Gly Val Ile Glu Thr Leu Phe Ser Lys Lys Ser Lys Ile Ser 
385                 390                 395                 400 


Glu Glu Arg Leu Gly Cys Thr Tyr Ile Cys Asp Tyr Leu Trp Lys Asp 
                405                 410                 415     


Phe Leu Ser Tyr Leu Ala Ala Lys Tyr Ile Asp Leu Gly Lys Gly Val 
            420                 425                 430         


Tyr His Phe Thr Met Lys Asp Lys Leu Asp Met Leu Asn Lys Asn Glu 
        435                 440                 445             


Ala Val Thr Asp Leu Arg Phe Gly Ile Val Ser Glu Lys Tyr Glu Lys 
    450                 455                 460                 


Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Glu Leu 
465                 470                 475                 480 


Asp Arg Asn Ile Ala Ala Tyr Val Thr Phe Ala Ala Asp Ile Phe Ala 
                485                 490                 495     


Lys Ser Val Ile Lys Ser Asp Tyr Arg Thr Lys Lys Asp Asn Asn Ser 
            500                 505                 510         


Asp Val Leu Gln Tyr Ser Asp Lys Glu Phe Arg Asn Ser Glu Val Ile 
        515                 520                 525             


Arg Asp Asn Ala Glu Lys Asn Ile Leu Gln Tyr Trp Gly Gly Tyr Ser 
    530                 535                 540                 


Arg Trp Gly Thr Glu Asn Ser Lys Leu Pro Glu Asn Asn Lys Val Ser 
545                 550                 555                 560 


Asp Phe Gly Lys Leu Asn Val Ser Asp Leu Cys Ile Asp Ile Lys Lys 
                565                 570                 575     


His Leu Ala Gly Ile Arg Asn Ser Ser Val His Tyr Thr Thr Lys Ile 
            580                 585                 590         


Lys Asn Glu Ser Ala Ala Asp Gly Ser Asn Val Lys Ile Leu Phe Glu 
        595                 600                 605             


Lys Asp Leu Ala Asp Ile Asn Ile Ile Tyr Ala Asp Lys Tyr Tyr Ser 
    610                 615                 620                 


Asn Asn Val Trp Met Phe Tyr Ser Leu Glu Asp Ile Asn Lys Leu Ile 
625                 630                 635                 640 


Ala Phe Leu Tyr Lys Glu Lys Arg Val Ile Arg Gln Val Gln Ile Pro 
                645                 650                 655     


Ser Phe Ser Arg Ile Leu Lys Arg Lys Ala Met Gln Asp Val Ile Asn 
            660                 665                 670         


Glu Ile Phe Lys Asp Asp Phe Asp Glu Asn Ile Val Asn Pro Glu Leu 
        675                 680                 685             


Lys Glu Lys Tyr Arg Asn Ser Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
    690                 695                 700                 


Tyr Asn Ala Phe Ile Ile Gln Pro Glu Leu Lys Glu Lys Phe Lys Asp 
705                 710                 715                 720 


Lys Ile Lys Thr Met Lys Ser Glu Leu Tyr Asn Lys Leu Lys Thr Ile 
                725                 730                 735     


Asp Lys Lys Glu Tyr Lys Ala Leu Tyr Cys Met Leu Ser Asn Glu Glu 
            740                 745                 750         


Ser Ala Leu Lys Asn Phe Ala Asp Arg Ile Tyr Ser Val Asp Gly Asp 
        755                 760                 765             


Asn Val Ser Phe Ala Asp Ile Cys Lys Ile Leu Met Thr Asp Tyr Asn 
    770                 775                 780                 


Met Gln Asn Gln Glu Lys Lys Asn Ile Glu Ser Met Glu Gln Lys Lys 
785                 790                 795                 800 


Lys Asn Lys Gly Lys Asp Glu Asn Tyr Lys His Phe Pro Leu Leu Leu 
                805                 810                 815     


His Lys Val Leu Lys Glu Leu Phe Ile Glu Tyr Leu Lys Gln Thr His 
            820                 825                 830         


Glu Leu Glu Phe Leu Arg Asn Asn Ile Cys Ile Lys Ser Asp Val Thr 
        835                 840                 845             


Met Glu Ser Phe Glu Ser Gln Ile Lys Gly Val Glu Ile Tyr Lys Asp 
    850                 855                 860                 


Leu Lys Glu Lys Ile Asp Lys Asn Asn Ser Leu Leu Asp Trp Tyr Val 
865                 870                 875                 880 


Ile Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asn 
                885                 890                 895     


Ile Lys Asn Tyr Ile Gln Phe Ala Thr Asn Ile Asp Lys Arg Ala Glu 
            900                 905                 910         


Ser Val Lys Asn Leu Thr Glu Ser Gly Met Val Lys Arg Ile Gln Tyr 
        915                 920                 925             


Tyr Asp Asp Ile Val Arg Thr Leu Glu Phe Ser Ala Gln Tyr Ile Gly 
    930                 935                 940                 


Lys Ile Ser Asn Asn Ile Asn Asp Tyr Phe Asn Ser Glu Asp Glu Tyr 
945                 950                 955                 960 


Val Ser Phe Leu Ser Lys Tyr Val Gly Phe Ile Asn Asp Lys Ser Glu 
                965                 970                 975     


Asp Val Leu Thr Glu Leu Lys Asp Phe Cys Arg Glu Lys Ile Asn Asn 
            980                 985                 990         


Gly Ser Gln Ile Ile Gly Ile Tyr  Tyr Gly Gly Asp Asn  Val Ile Ile 
        995                 1000                 1005             


Asn Arg  Asn Val Ile Tyr Ala  Gln Met Tyr Ser Asn  Ala Glu Val 
    1010                 1015                 1020             


Phe Ser  Asn Ile Tyr Lys Lys  Val Thr Lys Asn Asp  Ile Ile Asn 
    1025                 1030                 1035             


Tyr Tyr  Glu Lys Gln Asn Asp  Leu Lys Asp Val Phe  Lys Ser Gly 
    1040                 1045                 1050             


Val Cys  Gln Asn Glu Asp Glu  Gln Arg Ser Leu Cys  Glu Phe Gln 
    1055                 1060                 1065             


Gln Leu  Lys Asn Arg Ile Glu  Leu Thr Glu Leu Ser  Thr Tyr Ala 
    1070                 1075                 1080             


Asp Met  Val Asn Asp Phe Met  Ala Gln Phe Val Glu  Trp Ala Tyr 
    1085                 1090                 1095             


Leu Arg  Glu Arg Asp Leu Met  Tyr Phe Gln Leu Gly  Ile His Tyr 
    1100                 1105                 1110             


Ile Arg  Leu Phe Tyr Ser Asp  Asn Val Leu Asp Glu  Lys Tyr His 
    1115                 1120                 1125             


Lys Leu  Ser Asp Asn Val Ile  Asp Ile Glu Glu Gly  Ala Leu Leu 
    1130                 1135                 1140             


Tyr Gln  Ile Val Ala Met Tyr  Asp Tyr Glu Leu Arg  Ile Phe Glu 
    1145                 1150                 1155             


Thr Asp  Asn Ser Gly Asn Ala  Lys Arg Ile Gly Gln  Gly Gly Pro 
    1160                 1165                 1170             


Gly Lys  Ser Ile Pro Val Phe  Leu Lys Lys Tyr Cys  Ser Gly Thr 
    1175                 1180                 1185             


Asp Val  Tyr Glu Cys Gly Leu  Glu Leu Phe Glu Asp  Ile Asn Gln 
    1190                 1195                 1200             


His Glu  His Ile Ile Arg Phe  Arg Asn Asp Ile Ala  His Met Arg 
    1205                 1210                 1215             


Tyr Met  Ser Asn Gln Ala Met  Asn Ile Met Ser Ile  Val Ser Asn 
    1220                 1225                 1230             


Ile Tyr  Lys Ser Phe Phe Ala  Tyr Asp Thr Lys Leu  Lys Lys Ser 
    1235                 1240                 1245             


Ile Ser  Leu Val Phe Lys Asn  Ile Leu Met Arg Tyr  Gly Val Ile 
    1250                 1255                 1260             


Ala Asp  Leu Val Phe Ser Tyr  Asn Asn Lys Asn Gln  Ser Ile Lys 
    1265                 1270                 1275             


Asp Asp  Met Asp Ile Asn Ile  Ile Asn Ile Lys Asn  Leu Lys Ser 
    1280                 1285                 1290             


Asp Lys  Tyr Val Tyr Lys Ile  Val Asn Glu Asp Ile  Val Lys Gln 
    1295                 1300                 1305             


Val Glu  Ile Glu Ile Arg Asn  Gln Val Phe Leu Glu  Gln Leu His 
    1310                 1315                 1320             


Asn Leu  Leu Tyr Phe Ser Arg  
    1325                 1330 


<210>  944
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  944

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Thr Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Asp Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Ser Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val His Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1400                 1405                 1410         


<210>  945
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  945

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  946
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  946

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Ile  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  947
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  947

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  948
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  948

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Gly Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn Tyr Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Gly Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Gly Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Ser Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  949
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  949

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Pro Gly Thr Asp Thr 
            20                  25                  30          


Ile Gly Leu Lys Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Asp Lys Pro Lys Lys 
    50                  55                  60                  


Trp Lys Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Glu Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Ser Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Met Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Tyr Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ser Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Gln Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Leu Tyr Asn Ser Val Phe 
            660                 665                 670         


Ile Arg Lys Asn Phe Pro Glu Asp Ile Ser Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val Tyr Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Asp Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Asp Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asn  Ser Glu Lys Lys Glu  Ala Tyr Gln Lys Ile  Glu Val Asn 
    1100                 1105                 1110             


Gly Asp  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Val  Tyr Ala Pro Asp Glu  Lys Gly Asp 
    1130                 1135                 1140             


Ile Leu  Lys Glu Gln Cys Thr  Lys Gly Gly Ala Gly  Gly Lys Ile 
    1145                 1150                 1155             


Ser Ala  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Lys Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Lys Gln 
    1250                 1255                 1260             


Thr Thr  Ser Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Ser Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Lys  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Val Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Gly Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Pro Asn 
    1370                 1375                 1380         


<210>  950
<211>  1330
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  950

Met Lys Arg Glu Lys Asn Ile Thr Ile Met Lys Ile Ser Lys Val Asn 
1               5                   10                  15      


His Arg Arg Thr Ala Val Ala Leu Asn Gly Asp Lys Ser Glu Leu Gly 
            20                  25                  30          


Gly Ile Leu Tyr Glu Ala Pro Val Gln Lys Asp Lys Asn Gly Asn Tyr 
        35                  40                  45              


Asn Asp Val Ile Ala Glu Thr Gly Lys Val Val Asn Glu Ala Leu Asp 
    50                  55                  60                  


Lys Lys Ser Arg Leu Tyr Thr Pro Phe Asn Asn Gln Lys Val Ile Ile 
65                  70                  75                  80  


Asp Lys Asn Leu Gln Arg Tyr Ala Asn Asn Leu Lys Arg Cys Tyr Ile 
                85                  90                  95      


Asn Phe Val Lys Gln Tyr Val Asn Asn Lys Ser Phe Asn Tyr Lys Ala 
            100                 105                 110         


Met Gln Phe Ile Pro Asp Ile Gln Asn Pro Lys Thr Asn Asp Ala Val 
        115                 120                 125             


Asn Tyr Arg Thr Asp Arg Asp Asn Val Tyr Asn Lys Asn Lys Tyr Tyr 
    130                 135                 140                 


Asp Lys Gln Thr Lys Ser Lys Ser Lys Lys Phe Ile Tyr Glu Lys Ile 
145                 150                 155                 160 


Val Ile Pro Gln Asn Glu Gln Asn Ile Val Ile Ser Ala Leu Val Asn 
                165                 170                 175     


Cys Ser Leu Arg Lys Ser Leu Arg Lys Asp Val Ser Tyr Lys Thr Lys 
            180                 185                 190         


Ser Gly Glu Ile Lys Thr Tyr Asn Leu Pro Glu Leu Val Lys Lys Ser 
        195                 200                 205             


Met Arg Phe Tyr Cys Leu Glu Gly Gln Arg Glu Pro Asp Glu Lys Glu 
    210                 215                 220                 


Lys Tyr Glu Met Tyr Ile Leu Phe Ser Tyr Met Lys Glu Asp Lys Arg 
225                 230                 235                 240 


Thr Lys Asn Thr Asp Leu Leu Val Lys Ser Ile Ser Asn Gln Asn Thr 
                245                 250                 255     


Lys Val Lys Val Glu Asp Ile Asp Gly Asn Lys Leu Leu Lys Leu Ser 
            260                 265                 270         


Ile Ala Asp Thr Lys Lys Lys Pro Leu Trp Glu Tyr Leu Ile Lys Tyr 
        275                 280                 285             


Ala Asp Ser Ser Arg Gln Arg Glu Leu Met Tyr Asp Ile Arg Lys Lys 
    290                 295                 300                 


Ile Ile Leu Tyr Val Ala Gly Ile Glu Glu Tyr Glu Asn Ile Lys Glu 
305                 310                 315                 320 


Asp Ser Gly Leu Ser Lys Val Ser Trp Ser Lys Tyr Asn Ile Ser Asp 
                325                 330                 335     


Asn Lys Met Phe Phe Asp Ile Asn Ser Cys Thr Asp Lys Arg Lys Gln 
            340                 345                 350         


Asn Leu Glu Ile Lys Ile Arg Glu Ala Asn Ile Glu His Tyr Arg Asn 
        355                 360                 365             


Ala Ser Ser Lys Leu Cys Asp Asp Glu Ser Ile Phe Trp Phe Gln His 
    370                 375                 380                 


Phe Glu Gly Val Ile Glu Thr Leu Phe Ser Lys Lys Ser Lys Ile Ser 
385                 390                 395                 400 


Glu Glu Arg Leu Gly Cys Ala Tyr Ile Cys Asp Tyr Leu Trp Lys Asp 
                405                 410                 415     


Phe Leu Ser Tyr Leu Ala Ala Lys Tyr Ile Asp Leu Gly Lys Gly Val 
            420                 425                 430         


Tyr His Phe Thr Met Lys Asp Lys Leu Asp Met Leu Asn Lys Asn Glu 
        435                 440                 445             


Ala Ile Thr Asp Leu Arg Phe Gly Ile Val Ser Glu Lys Tyr Glu Lys 
    450                 455                 460                 


Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Glu Leu 
465                 470                 475                 480 


Asp Arg Asn Ile Ala Ala Tyr Val Thr Phe Ala Ala Asp Ile Phe Ala 
                485                 490                 495     


Lys Ser Val Ile Lys Ser Asp Tyr Arg Thr Lys Lys Asp Asn Asn Ser 
            500                 505                 510         


Asp Val Leu Gln Tyr Ser Asp Lys Glu Phe Arg Asn Ser Glu Val Ile 
        515                 520                 525             


Arg Asp Asn Ala Glu Lys Asn Ile Leu Gln Tyr Trp Gly Gly Tyr Ser 
    530                 535                 540                 


Arg Trp Gly Thr Glu Asn Ser Lys Leu Pro Glu Asn Asn Lys Val Ser 
545                 550                 555                 560 


Asp Phe Asp Lys Leu Asp Val Ser Asp Leu Cys Ile Asp Ile Lys Lys 
                565                 570                 575     


His Leu Ala Gly Ile Arg Asn Ser Ser Val His Tyr Thr Thr Lys Ile 
            580                 585                 590         


Lys Asn Glu Ser Ala Ala Asp Gly Ser Asn Val Lys Ile Leu Phe Glu 
        595                 600                 605             


Lys Asp Leu Ala Asp Ile Asn Ile Ile Tyr Ala Asp Lys Tyr Tyr Ser 
    610                 615                 620                 


Asn Asn Val Trp Met Phe Tyr Ser Leu Glu Asp Ile Asn Lys Leu Ile 
625                 630                 635                 640 


Ala Phe Leu Tyr Lys Glu Lys Arg Val Ile Arg Gln Val Gln Ile Pro 
                645                 650                 655     


Ser Phe Ser Arg Ile Leu Lys Arg Lys Ala Met Gln Asp Val Ile Asn 
            660                 665                 670         


Glu Ile Phe Lys Asp Asp Phe Asp Glu Asn Ile Val Asn Pro Glu Leu 
        675                 680                 685             


Lys Glu Lys Tyr Arg Asn Ser Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
    690                 695                 700                 


Tyr Asn Ala Phe Ile Ile Gln Pro Glu Leu Lys Glu Lys Phe Lys Asp 
705                 710                 715                 720 


Lys Ile Lys Thr Met Lys Ser Glu Leu Tyr Asn Lys Leu Lys Thr Ile 
                725                 730                 735     


Asp Lys Lys Glu Tyr Lys Ala Leu Tyr Cys Met Leu Ser Asn Glu Glu 
            740                 745                 750         


Ser Ala Leu Lys Asn Phe Ala Asp Arg Ile Tyr Ser Val Asp Gly Asp 
        755                 760                 765             


Asn Val Ser Phe Ala Asp Ile Cys Lys Ile Leu Met Thr Asp Tyr Asn 
    770                 775                 780                 


Met Gln Asn Gln Glu Lys Lys Asn Ile Glu Ser Met Glu Gln Lys Lys 
785                 790                 795                 800 


Lys Asn Lys Gly Lys Asp Glu Asn Tyr Lys His Phe Pro Leu Leu Leu 
                805                 810                 815     


His Lys Val Leu Lys Glu Leu Phe Ile Glu Tyr Leu Lys Gln Thr His 
            820                 825                 830         


Glu Leu Glu Phe Leu Arg Asn Asn Ile Cys Ile Lys Ser Asp Val Thr 
        835                 840                 845             


Met Glu Ser Phe Glu Ser Gln Ile Lys Gly Val Glu Ile Tyr Lys Asp 
    850                 855                 860                 


Leu Lys Glu Lys Ile Asp Lys Asn Asn Ser Leu Leu Asp Trp Tyr Val 
865                 870                 875                 880 


Ile Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asn 
                885                 890                 895     


Ile Lys Asn Tyr Ile Gln Phe Ala Thr Asn Ile Asp Lys Arg Ala Glu 
            900                 905                 910         


Ser Val Lys Asn Leu Thr Glu Ser Gly Met Val Lys Arg Ile Gln Tyr 
        915                 920                 925             


Tyr Asp Asp Ile Val Arg Thr Leu Glu Phe Ser Ala Gln Tyr Ile Gly 
    930                 935                 940                 


Lys Ile Ser Asn Asn Ile Asn Asp Tyr Phe Asn Ser Glu Asp Glu Tyr 
945                 950                 955                 960 


Val Ser Phe Leu Ser Lys Tyr Val Gly Phe Ile Asn Asp Lys Ser Glu 
                965                 970                 975     


Asp Val Leu Thr Glu Leu Lys Asp Phe Cys Arg Glu Lys Ile Asn Asn 
            980                 985                 990         


Gly Ser Gln Ile Ile Gly Ile Tyr  Tyr Gly Gly Asp Asn  Val Ile Ile 
        995                 1000                 1005             


Asn Arg  Asn Val Ile Tyr Ala  Gln Met Tyr Ser Asn  Ala Glu Val 
    1010                 1015                 1020             


Phe Ser  Asn Ile Tyr Lys Lys  Val Thr Lys Asn Asp  Ile Ile Asn 
    1025                 1030                 1035             


Tyr Tyr  Glu Lys Gln Asn Asp  Leu Lys Asp Val Phe  Lys Ser Gly 
    1040                 1045                 1050             


Val Cys  Gln Asn Glu Asp Glu  Gln Arg Ser Leu Cys  Glu Phe Gln 
    1055                 1060                 1065             


Gln Leu  Lys Asn Arg Ile Glu  Leu Thr Glu Leu Ser  Thr Tyr Ala 
    1070                 1075                 1080             


Asp Met  Val Asn Asp Phe Met  Ala Gln Phe Val Glu  Trp Ala Tyr 
    1085                 1090                 1095             


Leu Arg  Glu Arg Asp Leu Met  Tyr Phe Gln Leu Gly  Ile His Tyr 
    1100                 1105                 1110             


Ile Arg  Leu Phe Tyr Ser Asp  Asn Val Leu Asp Glu  Lys Tyr His 
    1115                 1120                 1125             


Lys Leu  Ser Asp Asn Val Ile  Asp Ile Glu Glu Gly  Ala Leu Leu 
    1130                 1135                 1140             


Tyr Gln  Ile Val Ala Met Tyr  Asp Tyr Glu Leu Arg  Ile Phe Glu 
    1145                 1150                 1155             


Thr Asp  Asn Ser Gly Asn Ala  Lys Arg Ile Gly Gln  Gly Gly Pro 
    1160                 1165                 1170             


Gly Lys  Ser Ile Pro Val Phe  Leu Lys Lys Tyr Cys  Asn Gly Thr 
    1175                 1180                 1185             


Asp Val  Tyr Glu Cys Gly Leu  Glu Leu Phe Glu Asp  Ile Asn Gln 
    1190                 1195                 1200             


His Glu  His Ile Ile Arg Phe  Arg Asn Asp Ile Ala  His Met Arg 
    1205                 1210                 1215             


Tyr Met  Ser Asn Gln Ala Met  Asn Ile Met Ser Ile  Val Ser Asn 
    1220                 1225                 1230             


Ile Tyr  Lys Ser Phe Phe Ala  Tyr Asp Thr Lys Leu  Lys Lys Ser 
    1235                 1240                 1245             


Ile Ser  Leu Val Phe Lys Asn  Ile Leu Met Arg Tyr  Gly Val Ile 
    1250                 1255                 1260             


Ala Asp  Leu Val Phe Ser Tyr  Asn Asn Lys Asn Gln  Ser Ile Lys 
    1265                 1270                 1275             


Asp Asp  Met Asp Ile Asn Ile  Ile Asn Ile Lys Asn  Leu Lys Ser 
    1280                 1285                 1290             


Asp Lys  Tyr Val Tyr Lys Ile  Val Asn Glu Asp Ile  Val Lys Gln 
    1295                 1300                 1305             


Val Glu  Ile Glu Ile Arg Asn  Gln Val Phe Leu Glu  Gln Leu His 
    1310                 1315                 1320             


Asn Leu  Leu Tyr Phe Ser Arg  
    1325                 1330 


<210>  951
<211>  1345
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  951

Met Lys Ile Ser Lys Glu Ser His Arg Lys Thr Gly Val Leu Ile Asn 
1               5                   10                  15      


Asn Ser Gly Ala Glu Gly Ile Leu Tyr Lys Asp Pro Leu Lys Ser Asn 
            20                  25                  30          


Glu Lys Ile Glu Asp Val Val Asn Ala Arg Ala Asn Ser Thr Lys Arg 
        35                  40                  45              


Leu Phe Asn Leu Phe Gly Thr Gly Glu Glu Ser Lys Asp Ile Ser Lys 
    50                  55                  60                  


Asn Ala Lys Glu Val Ala Lys Thr Val Asn Arg Ala Ile Gly Asn Leu 
65                  70                  75                  80  


Lys Ala Asn Lys Lys Phe Asn Lys Lys Glu Arg Ile Asn Ser Glu Leu 
                85                  90                  95      


Lys Val Glu Gln Leu Val Glu Glu Ile Ile Asn Asn Lys Lys Phe Asp 
            100                 105                 110         


Phe Lys Glu His Asp Val Asp Glu Ala Leu Asp Arg Leu Leu Lys Lys 
        115                 120                 125             


Ser Phe Arg Val Ala Pro Tyr Lys Gly Ala Val Arg Thr Leu Leu Met 
    130                 135                 140                 


Ser Thr Leu Val Glu Lys Lys Glu Leu Ser Val Glu Glu Asn Asp Lys 
145                 150                 155                 160 


Val Gln Asn Tyr Phe Ile Lys Lys Leu Val Ala Glu Tyr Asp Lys Thr 
                165                 170                 175     


Leu Ile Lys Arg Gln Ile Pro Lys Ala Leu Val Asn Gln Asn Met Val 
            180                 185                 190         


Ile Gln Pro Ser Ser Asn Asp Gly Thr Leu Val Ile Ala Glu Thr Asn 
        195                 200                 205             


Lys Ser Lys Glu Thr Lys Leu Thr Glu Lys Asp Ala Phe Arg Leu Phe 
    210                 215                 220                 


Leu Arg Asp Tyr Ala Thr Leu Asp Asp Lys Leu Arg His Glu Met Arg 
225                 230                 235                 240 


Leu Lys Leu Arg Arg Leu Val Asp Leu Tyr Phe Tyr Gly Glu Glu Ala 
                245                 250                 255     


Val Ile Lys Glu Asp Phe Asp Glu Trp Glu Ile His Glu Lys Arg Lys 
            260                 265                 270         


Ala Asp Thr Ala Leu Phe Val Asp Lys Ala Thr Lys Ile Lys Val Leu 
        275                 280                 285             


Lys Asn Gly Val Lys Arg Glu Ile Leu Asp Val Asp Thr Thr Leu Asp 
    290                 295                 300                 


Ala Ile Arg Gly Lys Asn Ile Ser Cys Tyr Arg Lys Ser Val Ser Ile 
305                 310                 315                 320 


Val Lys Asp Asn Asn Thr Gly Tyr Phe Asp Ser Glu Ala Leu Asn Lys 
                325                 330                 335     


Phe Trp Ile His His Ile Glu Asn Glu Val Glu Arg Ile Tyr Gly His 
            340                 345                 350         


Leu Lys Asn Asp Thr Gly Asn Tyr Lys Phe Gln Leu Gly Tyr Leu Ser 
        355                 360                 365             


Glu Lys Val Trp Lys Gly Ile Ile Asn Tyr Leu Ser Ile Lys Tyr Ile 
    370                 375                 380                 


Ala Glu Gly Lys Ala Val Tyr His Tyr Ala Met Lys Ala Leu Ser Arg 
385                 390                 395                 400 


Asp Asp Thr Thr Lys Thr Phe Gly Lys Val Asp Glu Lys Tyr Leu Lys 
                405                 410                 415     


Gly Ile Ser Ser Phe Glu Tyr Glu Arg Ile Lys Ala Glu Glu Thr Leu 
            420                 425                 430         


Gln Arg Glu Cys Ala Val Asn Val Ala Phe Ala Ala Asn His Leu Ala 
        435                 440                 445             


Asn Ala Thr Val Gln Leu Asp Asp Ile Asn Thr Asp Phe Leu Leu Leu 
    450                 455                 460                 


Lys Asn Lys Glu Pro Gln Glu Asp Ser Lys Lys Lys Gly Ile Lys Ser 
465                 470                 475                 480 


Leu Ala Glu Cys Ala Ser Ala Lys Pro Asn Thr Leu Arg Asn Ile Leu 
                485                 490                 495     


Gln Phe Phe Gly Gly Lys Ser Thr Trp Glu Asp Phe Asp Phe Ser Gly 
            500                 505                 510         


Tyr Asp Glu Ile Glu Leu Leu Asn Asp Met Lys Glu Met Ile Tyr Ser 
        515                 520                 525             


Leu Arg Asn Met Ser Phe His Phe Lys Thr Glu Asn Val Asn Glu Gly 
    530                 535                 540                 


Lys Trp Asn Thr Glu Leu Ile Gly Arg Met Phe Ala His Asp Cys Asp 
545                 550                 555                 560 


Arg Ala Ser Ile Val Gln Lys Asn Lys Leu Tyr Ser Asn Asn Ala Ala 
                565                 570                 575     


Met Phe Tyr Asn Ser Ser Asp Leu Ala Lys Leu Leu Asp Lys Leu Tyr 
            580                 585                 590         


Asn His Tyr Asn Glu Arg Ala Ser Gln Val Pro Ser Phe Asn Thr Val 
        595                 600                 605             


Phe Val Arg Lys Asn Phe Pro Glu Tyr Leu Lys Gln Gln Gln Ile Ser 
    610                 615                 620                 


Pro Ala Leu Ser Ala Glu Asp Thr Leu Lys Trp Gln Ser Ala Val Tyr 
625                 630                 635                 640 


Tyr Leu Tyr Lys Glu Ile Tyr Tyr Asn Ala Phe Leu Gln Asp Lys Glu 
                645                 650                 655     


Ser Phe Asn Leu Leu Lys Gln Tyr Val Arg Asn Leu Asp Glu His Cys 
            660                 665                 670         


Gln Asp Lys Asn Gln Ala Gly Ala Asn Arg Asp Phe Lys Ala Ala Phe 
        675                 680                 685             


Glu Ile Tyr Ser Glu Ser Gly Ser Met Ser Ala Thr Cys Gln Met Ile 
    690                 695                 700                 


Met Thr Glu Tyr Asn Asn Gln Asn Lys Gly Asn Arg Val Gly Ile Ser 
705                 710                 715                 720 


Gly Arg Thr Asn Ser Asp Asp Lys Leu Ile Phe Gln His Tyr Lys Met 
                725                 730                 735     


Ile Leu Phe Asp Gly Leu Lys Ala Ala Phe Ser Glu Tyr Leu Lys Lys 
            740                 745                 750         


Asn Gly Glu Val Tyr Asp Phe Ile Lys Thr Pro Lys Leu Val Thr Ile 
        755                 760                 765             


Leu Val Asp Ala Asp Val Phe Leu Gly Asp Tyr Lys Ser His Gln Tyr 
    770                 775                 780                 


Asp Ser Leu Val Glu Asn Val Lys Thr Asn Pro Glu Leu Gln Lys Trp 
785                 790                 795                 800 


Tyr Val Thr Gly Arg Leu Leu Asn Pro Lys Gln Val Asn Gln Leu Ile 
                805                 810                 815     


Gly Thr Phe Arg Ser Tyr Val Gln Tyr Val Asn Asp Val Met Arg Arg 
            820                 825                 830         


Ala Lys Gln Val Lys Asn Pro Leu Thr Asp Glu Thr Ile Ser Ile Asp 
        835                 840                 845             


Val Asp Asn Ile Ile Lys Val Leu Asp Ile Cys Thr Lys Leu Asn Gly 
    850                 855                 860                 


Ala Thr Ser Asn Lys Ile Asp Asp Tyr Phe Asp Asn Gly Asp Glu Tyr 
865                 870                 875                 880 


Ala Lys Tyr Leu Gly Asn Phe Val Asp Phe Gly Leu Arg Asp Asp Val 
                885                 890                 895     


Asn Leu Ala Asn Ala Lys Leu Ala Gly Phe Cys Asn Gln Glu Val Asp 
            900                 905                 910         


Gly Gln Lys Ile Gly Ile Tyr His Asp Gly Thr Asn Pro Val Leu Asn 
        915                 920                 925             


Arg Asn Val Val Leu Cys Lys Leu Tyr Gly Ala Ser Asp Val Val Ala 
    930                 935                 940                 


Gln Ala Gly Ile Leu Pro Val Asp Phe Glu Ile Ile Lys Lys Tyr Met 
945                 950                 955                 960 


Gln Leu Ser Gly Glu Ile Lys Glu Tyr Gln Leu Thr Gly Val Cys Lys 
                965                 970                 975     


Thr Lys Glu Asp Gln Gln Arg Leu Lys Lys Tyr Gln Glu Leu Lys Asn 
            980                 985                 990         


Met Val Glu Leu Arg Asn Ile Val  Asp Tyr Ser Glu Leu  Val Asp Glu 
        995                 1000                 1005             


Leu Gln  Gly Gln Leu Ile Asn  Trp Gly Tyr Leu Arg  Glu Arg Asp 
    1010                 1015                 1020             


Leu Met  Tyr Phe Gln Leu Gly  Phe His Tyr Leu Ala  Leu Asn Asn 
    1025                 1030                 1035             


Glu Ser  Lys Lys Pro Glu Gly  Tyr Glu Lys Ala Gly  Asp Ile Asn 
    1040                 1045                 1050             


Gly Ala  Ile Leu Tyr Gln Ile  Val Ala Met Tyr Thr  Asn Gly Leu 
    1055                 1060                 1065             


Ser Leu  Ile Asp Ala Thr Gly  Lys Ser Lys Gly Asn  Ala Lys Ala 
    1070                 1075                 1080             


Ser Ala  Gly Ala Lys Ile Gly  Ser Phe Cys Ser Tyr  Ser Lys Ser 
    1085                 1090                 1095             


Leu Arg  Asn Val Pro Gly Asp  Thr Lys Glu Glu Ile  Asp Pro Ile 
    1100                 1105                 1110             


Tyr His  Ala Gly Leu Glu Leu  Phe Glu Asn Ile Asn  Glu His Asp 
    1115                 1120                 1125             


Gln Cys  Val Ala Leu Arg Asn  Tyr Ile Glu His Phe  His Tyr Tyr 
    1130                 1135                 1140             


Ala Lys  Met Asp Arg Ser Leu  Leu Asp Ile Tyr Ser  Glu Val Phe 
    1145                 1150                 1155             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Ala Lys  Asn Val Pro 
    1160                 1165                 1170             


Asn Met  Leu Tyr Asn Ile Leu  Leu Gln His Leu Val  Val Pro Ser 
    1175                 1180                 1185             


Phe Glu  Phe Asn Ser Gly Glu  Lys Lys Leu Gly Asp  His Asn Ser 
    1190                 1195                 1200             


Leu Ser  Lys Lys Arg Ala Thr  Ile Ser Leu Lys Ser  Glu Asn Gly 
    1205                 1210                 1215             


Leu Ala  Ser Glu Lys Phe Thr  Tyr Lys Ile Gly Asp  Lys Lys Asn 
    1220                 1225                 1230             


Pro Ile  Lys Leu Ser Ala Arg  Ser Asn Asp Tyr Leu  Ser Asp Val 
    1235                 1240                 1245             


Ala Ala  Ile Leu Tyr Tyr Pro  Asp Lys Ala Pro Thr  Gly Val Val 
    1250                 1255                 1260             


Arg Asp  Thr Val Lys Glu Asp  Asn Ser Ala Lys Glu  Gln Gly Lys 
    1265                 1270                 1275             


Lys Ser  Lys Asp Phe Ala Gly  Pro Arg Asn Asn Lys  Asn Asn Asn 
    1280                 1285                 1290             


Tyr His  Gly His Asn Asn Gly  Tyr Asn Asn Gln Lys  Arg Asp Tyr 
    1295                 1300                 1305             


Ser Lys  Gln Asn Glu Asn Glu  His Ser Gly Ser Leu  Ser Thr Gly 
    1310                 1315                 1320             


Leu Phe  Asp Ala Ala Asn Tyr  Lys Lys Asp Arg His  Asn Asn Asn 
    1325                 1330                 1335             


Gln Asn  Tyr Lys Lys Arg Lys  
    1340                 1345 


<210>  952
<211>  1225
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  952

Met Lys Ile Thr Lys Arg Lys Trp Gly Glu His His Pro Pro Leu Tyr 
1               5                   10                  15      


Phe Tyr Arg Asp Glu Asp Ser Gly Arg Leu Leu Ala Gln Asn Asp Arg 
            20                  25                  30          


Lys Gln Asp Tyr Thr Asp Thr Leu Phe Asn Asp Ile Ala Gln Asp Thr 
        35                  40                  45              


Phe Glu Arg Ser Leu Arg Asn Arg Leu Leu Lys Thr Pro Glu Lys Gly 
    50                  55                  60                  


Asp Lys Arg Phe Tyr Ser Asn Glu Ile Val Lys Leu Val Glu Lys Leu 
65                  70                  75                  80  


Cys Gln Gly Ala Asp Val Ala Glu Ile Met Lys Ser Met Glu Arg Ser 
                85                  90                  95      


Glu Lys Leu Arg Pro Lys Asn Glu Lys Glu Ile Lys Asn Leu Lys Lys 
            100                 105                 110         


Gln Leu Tyr Gly Thr Leu Ser Glu Tyr Gly Lys Arg Tyr Thr Ala Pro 
        115                 120                 125             


Glu Gly Ala Met Thr Leu Asn Asp Ala Leu Phe Tyr Leu Val Glu Gly 
    130                 135                 140                 


Asn Pro Leu Lys Gln Ala Met Ala Lys Ala Glu Leu Gly Lys Ile Arg 
145                 150                 155                 160 


Glu Ala Leu Ile Lys Glu Lys Glu Asn Arg Ile Asn Arg Val Arg Tyr 
                165                 170                 175     


Ser Ile Lys Asn Asn Lys Ile Pro Leu Arg Ile Gln Glu Asp Gly Gly 
            180                 185                 190         


Ile Thr Pro Asn Asn Asp Arg Ala Ala Trp Leu Leu Gly Leu Met Lys 
        195                 200                 205             


Pro Ala Asp Pro Ala Lys Gly Ile Thr Asp Cys Tyr Pro Leu Leu Gly 
    210                 215                 220                 


Glu Leu Glu Glu Val Phe Asp Phe Asp Lys Leu Ser Lys Thr Leu His 
225                 230                 235                 240 


Glu Lys Ile Ser Arg Cys Gln Gly Arg Pro Arg Ser Ile Ala Met Ala 
                245                 250                 255     


Val Asp Glu Ala Leu Lys Gln Tyr Leu Arg Glu Leu Trp Glu Lys Ser 
            260                 265                 270         


Pro Ser Arg Gln Gln Asp Leu Lys Tyr Tyr Phe Gln Ala Val Gln Glu 
        275                 280                 285             


Tyr Phe Lys Asp Asn Phe Pro Ile Arg Thr Lys Arg Met Gly Ala Arg 
    290                 295                 300                 


Leu Arg Gln Glu Leu Leu Lys Asp Lys Thr Ser Leu Ser Arg Leu Leu 
305                 310                 315                 320 


Glu Pro Lys His Met Ala Asn Ala Val Arg Arg Arg Leu Ile Asn Gln 
                325                 330                 335     


Ser Thr Gln Met His Ile Leu Tyr Gly Lys Leu Tyr Ala Tyr Cys Cys 
            340                 345                 350         


Gly Glu Asp Gly Arg Leu Leu Val Asn Ser Glu Thr Leu Gln Arg Ile 
        355                 360                 365             


Gln Val His Glu Ala Val Lys Lys Gln Ala Met Thr Ala Val Leu Trp 
    370                 375                 380                 


Ser Ile Ser Arg Leu Arg Tyr Phe Tyr Gln Phe Glu Asp Gly Asp Ile 
385                 390                 395                 400 


Leu Ser Asn Lys Asn Pro Ile Lys Asp Phe Arg Asp Lys Phe Leu Arg 
                405                 410                 415     


Asp Thr Asn Lys Tyr Thr His Glu Asp Val Glu Ala Cys Lys Glu Lys 
            420                 425                 430         


Leu Gln Asp Phe Phe Pro Leu Lys Glu Leu Gln Glu Lys Ile Lys Glu 
        435                 440                 445             


Asp Ala Lys Gly Leu Gln Glu Thr Asp Asn Lys Gln Ala Asp Thr Thr 
    450                 455                 460                 


Asp Phe Lys Ala Ile Gly His Ile Val Arg Asp Asp Arg Lys Leu Cys 
465                 470                 475                 480 


Asn Gln Leu Leu Ala Glu Cys Val Ser Cys Ile Gly Glu Leu Arg His 
                485                 490                 495     


His Ile Phe His Tyr Lys Asn Val Thr Leu Ile Gln Ala Leu Lys Arg 
            500                 505                 510         


Ile Ala Asp Lys Val Lys Pro Glu Asp Leu Ser Val Leu Arg Ala Ile 
        515                 520                 525             


Tyr Leu Leu Asp Arg Arg Asn Leu Lys Lys Ala Phe Ala Lys Arg Ile 
    530                 535                 540                 


Ser Ser Met Asn Leu Pro Leu Tyr Tyr Arg Glu Asp Leu Leu Ser Arg 
545                 550                 555                 560 


Ile Phe Lys Lys Glu Gly Thr Ala Phe Phe Leu Tyr Ser Ala Lys Ile 
                565                 570                 575     


Gln Met Thr Pro Ser Phe Gln Arg Val Tyr Glu Arg Gly Lys Asn Leu 
            580                 585                 590         


Arg Arg Glu Phe Glu Cys Glu Arg Met Lys Ala Glu Ala Ser Asn Gly 
        595                 600                 605             


Gln Asn Gly Gln Asp Gly Asp Arg Leu Lys Trp Phe Arg Gln Leu Ala 
    610                 615                 620                 


Ala Gly Asp Ser Ala Asp Thr His Phe Asn Trp Ala Val Glu Ala Tyr 
625                 630                 635                 640 


Ala Glu Ser Ala Ala Asp Val Glu Asn Asn Val Glu Phe Asp Thr Asp 
                645                 650                 655     


Val Asp Ala Gln Arg Ala Leu Arg Asn Leu Leu Leu Leu Ile Tyr Arg 
            660                 665                 670         


His His Phe Leu Pro Glu Val Gln Lys Asp Glu Thr Leu Val Thr Gly 
        675                 680                 685             


Lys Ile His Lys Val Leu Glu Arg Asn Arg Gln Leu Ser Glu Gly Gln 
    690                 695                 700                 


Gly Pro Asn Gln Gly Lys Ala His Gly Tyr Ser Val Ile Glu Glu Leu 
705                 710                 715                 720 


Tyr His Glu Gly Met Pro Leu Ser Asp Leu Met Lys Gln Leu Gln Arg 
                725                 730                 735     


Arg Ile Ser Glu Thr Glu Arg Glu Ser Arg Glu Leu Ala Gln Glu Lys 
            740                 745                 750         


Thr Asp Tyr Ala Gln Arg Phe Ile Leu Asp Ile Phe Ala Glu Ala Phe 
        755                 760                 765             


Asn Asp Phe Leu Glu Ala His Tyr Gly Glu Glu Tyr Leu Glu Ile Met 
    770                 775                 780                 


Ser Pro Arg Lys Asp Ala Glu Ala Ala Lys Lys Trp Val Lys Glu Ser 
785                 790                 795                 800 


Lys Thr Val Asp Leu Lys Thr Ser Ile Asp Glu Lys Glu Pro Glu Gly 
                805                 810                 815     


His Leu Leu Val Leu Tyr Pro Val Leu Arg Leu Leu Asp Glu Arg Glu 
            820                 825                 830         


Leu Gly Glu Leu Gln Gln Gln Met Ile Arg Tyr Arg Thr Ser Leu Ala 
        835                 840                 845             


Ser Trp Gln Gly Glu Ser Asn Phe Ser Glu Glu Ile Arg Ile Ala Gly 
    850                 855                 860                 


Gln Ile Glu Glu Leu Thr Glu Leu Val Lys Leu Thr Glu Pro Glu Pro 
865                 870                 875                 880 


Gln Phe Ala Glu Glu Val Trp Gly Lys Arg Ala Lys Glu Ala Phe Glu 
                885                 890                 895     


Asp Phe Ile Glu Gly Asn Met Lys Asn Tyr Glu Ala Phe Tyr Leu Gln 
            900                 905                 910         


Ser Asp Asn Asn Thr Pro Val Tyr Arg Arg Asn Met Ser Arg Leu Leu 
        915                 920                 925             


Arg Ser Gly Leu Met Gly Val Tyr Gln Lys Val Leu Ala Ser His Lys 
    930                 935                 940                 


Gln Ala Leu Lys Arg Asp Tyr Leu Leu Trp Ser Glu Lys His Trp Asn 
945                 950                 955                 960 


Val Lys Asp Glu Asn Gly Ala Asp Ile Ser Ser Ala Glu Gln Ala Gln 
                965                 970                 975     


Cys Leu Leu Gln Arg Leu His Arg Lys Tyr Ala Glu Ser Pro Ser Arg 
            980                 985                 990         


Phe Thr Glu Glu Asp Cys Lys Leu  Tyr Glu Lys Val Leu  Arg Arg Leu 
        995                 1000                 1005             


Glu Asp  Tyr Asn Gln Ala Val  Lys Asn Leu Ser Phe  Ser Ser Leu 
    1010                 1015                 1020             


Tyr Glu  Ile Cys Val Leu Asn  Leu Glu Ile Leu Ser  Arg Trp Val 
    1025                 1030                 1035             


Gly Phe  Val Gln Asp Trp Glu  Arg Asp Met Tyr Phe  Leu Leu Leu 
    1040                 1045                 1050             


Ala Trp  Val Arg Gln Gly Lys  Leu Asp Gly Ile Lys  Glu Glu Asp 
    1055                 1060                 1065             


Val Arg  Asp Ile Phe Ser Glu  Gly Asn Ile Ile Arg  Asn Leu Val 
    1070                 1075                 1080             


Asp Thr  Leu Lys Gly Glu Asn  Met Asn Ala Phe Glu  Ser Val Tyr 
    1085                 1090                 1095             


Phe Pro  Glu Asn Lys Gly Ser  Lys Tyr Leu Gly Val  Arg Asn Asp 
    1100                 1105                 1110             


Val Ala  His Leu Asp Leu Met  Arg Lys Asn Gly Trp  Arg Leu Glu 
    1115                 1120                 1125             


Ala Gly  Lys Thr Cys Ser Val  Met Glu Asp Tyr Ile  Asn Arg Leu 
    1130                 1135                 1140             


Arg Phe  Leu Leu Ser Tyr Asp  Gln Lys Arg Met Asn  Ala Val Thr 
    1145                 1150                 1155             


Lys Thr  Leu Gln Gln Ile Phe  Asp Arg His Lys Val  Lys Ile Arg 
    1160                 1165                 1170             


Phe Thr  Val Glu Lys Gly Gly  Met Leu Lys Ile Glu  Asp Val Thr 
    1175                 1180                 1185             


Ala Asp  Lys Ile Ala His Leu  Lys Gly Ser Arg Leu  Ser Gly Ile 
    1190                 1195                 1200             


Glu Ile  Leu Ser His Gly Glu  Arg Phe Ile Asp Thr  Leu Lys Ala 
    1205                 1210                 1215             


Leu Met  Val Tyr Pro Arg Gly  
    1220                 1225 


<210>  953
<211>  1163
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  953

Met Gly Ser Gly Lys Tyr Arg Ile Thr Lys Ile Ala Arg Lys Trp Asp 
1               5                   10                  15      


Lys Asn Glu Asn Trp Glu Lys Ile Ile Leu Lys Arg Ile Val Gly Asn 
            20                  25                  30          


Lys Lys Ile Lys Tyr Val Asn Glu Asn Asn Asn Lys Asp Val Asp Ile 
        35                  40                  45              


Thr Asp Thr Tyr Tyr Asn Ile Leu Ser Lys Asn Asn Ser Lys Phe Leu 
    50                  55                  60                  


Gly Ser Glu Glu Gln Phe Leu Phe Lys Val Asn Lys Met Asp Arg Asn 
65                  70                  75                  80  


Ile Lys Asn Asp Tyr Val Ile Ile Lys Asp Tyr Asn Asp Glu Glu Phe 
                85                  90                  95      


Glu Lys Phe Asp Lys Lys Ile Phe Phe Ser Arg Lys Ile Lys Val Asn 
            100                 105                 110         


Asn Glu Asp Arg Glu Lys Ile Cys Arg Asn Phe Tyr Glu Asp Glu Arg 
        115                 120                 125             


Glu Ile Met Lys Lys Arg Leu Glu Glu Ala Lys Asn Phe Asn Asn Ile 
    130                 135                 140                 


Ile Phe Asn Ile Cys Asn Lys Ile Phe Lys Leu Glu Tyr Leu Asp Tyr 
145                 150                 155                 160 


Thr Asp Glu Lys Val Tyr Lys Ile Phe Gln Asn Glu Ile Lys Val Lys 
                165                 170                 175     


Asp Val Lys Asn Leu Lys Glu Ala Phe Lys Gln Gln Glu Lys Gly Leu 
            180                 185                 190         


Glu Thr Asp Lys Leu Leu Ala Ile Ser Phe Asn Lys Asn Arg Asn Asn 
        195                 200                 205             


Ile Leu Leu Glu Phe Val Gln Gln Ile Thr Lys Gln Glu Phe Lys Asn 
    210                 215                 220                 


Gln Lys Glu Leu Glu Asn Trp Phe Ser His Ser Gly Glu Lys Tyr Cys 
225                 230                 235                 240 


Lys Lys Ile Phe Lys Ile Tyr Ser Asn Met Ser Gln Lys Glu Lys Tyr 
                245                 250                 255     


Ser Lys Leu Leu Gly His Lys Asn Lys Ser Ile Ala Ser Ile Ser Glu 
            260                 265                 270         


Lys Lys Glu Thr Leu Gln Arg Arg Leu Lys Leu Gly Asn Tyr Ser Asn 
        275                 280                 285             


Tyr Asp Leu Arg Lys Tyr Tyr Gln Lys Asp Tyr Lys Glu Glu Ala Ile 
    290                 295                 300                 


Arg Glu Leu Lys Asp Lys Asn Lys Glu Glu Leu Glu Arg Glu Ile Glu 
305                 310                 315                 320 


Lys Leu Ile Lys Glu Asn Tyr Lys Ile Asp Glu Leu Cys Asp Glu Ile 
                325                 330                 335     


Ser Asn Leu Glu Phe Ser Phe Val Asp Ser Lys Lys Glu Asn Lys Asp 
            340                 345                 350         


Lys Met Ser Glu Ile Ile Val Lys Ile Lys Glu His Tyr Lys Asn Asn 
        355                 360                 365             


Val Asn Ile Glu Glu Arg Leu Glu Asn Lys Glu Lys Tyr Ile Leu Ser 
    370                 375                 380                 


Met Ile His Asn Tyr Val Lys Gly Arg Tyr Arg Lys Cys Leu Glu Leu 
385                 390                 395                 400 


Gln Gln Lys Glu Asn Val Asp Phe Glu Asn Leu Glu Lys Arg Ile Lys 
                405                 410                 415     


Glu Ile Phe Asp Ser Asn Glu Val Thr Lys Lys Leu Lys Lys Ser Ile 
            420                 425                 430         


Ile Asn Lys Val Asn Ser Tyr Lys Ile Phe Glu Met Lys Phe Gln Asn 
        435                 440                 445             


Pro Asn Ile Glu Ser Ser Asp Asp Leu Glu Ile Leu Lys Ala Glu Glu 
    450                 455                 460                 


Thr Phe Leu Asn Lys Leu Ser Thr Ala Val Ser Lys Val Gly Tyr Thr 
465                 470                 475                 480 


Leu Asn Thr Leu Leu Glu Val Asn Pro Glu Lys Asp Ile Leu Glu Lys 
                485                 490                 495     


Tyr Glu Glu Val Glu Lys Leu Cys Thr Asn Asn Ser Ile Lys Asn Leu 
            500                 505                 510         


Cys Thr Val Tyr Ser Glu Ile Asn Asn Asn Glu Lys Leu Leu Lys Gly 
        515                 520                 525             


Met Ile Tyr Phe Ile Gln Gly Leu Arg Gln Gln Val Leu His Pro Lys 
    530                 535                 540                 


Ile Leu Trp Glu Lys Asn Val His Lys Ala Glu Lys Val Lys Glu Lys 
545                 550                 555                 560 


Glu Lys Ile Val Ile Arg Phe Gln Asn Glu Gly Lys Ala Tyr Asn Lys 
                565                 570                 575     


Lys Arg Ile Glu Glu Tyr Phe Glu Asn Ile Leu Glu Lys Ile Pro Asn 
            580                 585                 590         


Tyr Phe Ile Glu Lys Tyr Glu Ser Asn Asn Val Phe Asn Ile Tyr Arg 
        595                 600                 605             


Asn Phe Ile Asp Glu Ile Phe Glu Ile Ile Asp Lys Phe Asp Phe Lys 
    610                 615                 620                 


Glu Ser Asn Ser Ile Ser Tyr Leu Phe Pro Lys Phe His Lys Ile Tyr 
625                 630                 635                 640 


Lys Arg Ile Cys Lys Ser Glu Asn Ile Asn Asp Arg Gln Asn Gly Ala 
                645                 650                 655     


Arg Lys Tyr Leu Leu Gln Thr Ile Tyr Tyr Tyr Tyr Phe Gln Tyr Glu 
            660                 665                 670         


Ile Glu Asn Asn Lys Asn Asp Ile Phe Lys Tyr Leu Asn Leu Tyr Lys 
        675                 680                 685             


Ser Lys Ile Lys Ala Lys Lys Ile Ser Tyr Ser His Ile Ile Asp Asn 
    690                 695                 700                 


Lys Asp Val Asn Asn Lys Asn Ile Glu Ile Leu Tyr Arg Asn Ile Gln 
705                 710                 715                 720 


Arg Glu Gly Met Leu Asn Asn Arg Leu Leu Gln Met Asn Asn Glu Trp 
                725                 730                 735     


Ile Glu Phe Met Val Val Gln Phe Ser Glu Phe Leu Thr Asn Lys Lys 
            740                 745                 750         


Leu Asn Trp Ile Leu Asp Asp Leu Ser Glu Tyr Lys Lys Lys Glu Lys 
        755                 760                 765             


Leu Asp Glu Asn Asp Lys Asn Lys Leu Leu Lys Thr Leu Lys Gln Lys 
    770                 775                 780                 


Met Asn Lys Lys Ile Thr Tyr Ser Asn Asp Ser Tyr Val Phe Ile Ser 
785                 790                 795                 800 


Leu Ala Gln Phe Leu Asp Leu Lys Glu Ile Ser Asn Leu Ile His Asp 
                805                 810                 815     


Ile Lys Lys Phe Ile Gln Phe Arg Glu Lys Asn Val Ser Lys Tyr Lys 
            820                 825                 830         


Pro Glu Lys Asn Lys Leu Tyr Ile Lys Glu Leu Arg Lys Val Leu Tyr 
        835                 840                 845             


Ile Leu Lys Val Met Leu Glu His Lys Glu Arg Val Ile Gln Lys His 
    850                 855                 860                 


Tyr Leu Glu Ser Tyr Asp Glu Asn Ile Ser Ile Ile Tyr Gly Lys Asp 
865                 870                 875                 880 


Ile Glu Arg Lys Asp Ile Lys Asp Ile Lys Ile Lys Ile Lys Asn Glu 
                885                 890                 895     


Asn Gln Glu Val Ile Asn Gln Pro Leu Tyr Lys Ser Gly Asn Asp Glu 
            900                 905                 910         


Asn Ser Ser Trp Ile Val Leu Tyr Gly Ile Glu Gln Ala Lys Arg Asn 
        915                 920                 925             


Gly Thr Phe Lys Phe Phe Glu Gly Phe Phe Asn Leu Asn Asp Asp Ile 
    930                 935                 940                 


Lys Leu Cys Lys Glu Asn Ile Glu Lys Tyr Glu Glu Leu Tyr Asn Glu 
945                 950                 955                 960 


Lys Glu Glu Asn Gln Arg Lys Val Asp Glu Tyr Ile Ser Ser Glu Glu 
                965                 970                 975     


Asn Asn Asn Ile Asp Glu Ile Glu Glu Ile Asn Asn Asn Lys Gln Leu 
            980                 985                 990         


Phe Tyr Tyr Tyr Lys Asn Met Ile  Tyr Gly Asp Gly Leu  Lys Lys Gly 
        995                 1000                 1005             


Tyr Asp  Phe Ile Asn Asp Ile  Tyr Ser His Tyr Leu  Ser Trp Ala 
    1010                 1015                 1020             


Tyr Arg  Val Glu Arg Asp Cys  Lys Ile Tyr Lys Ile  Lys Glu Tyr 
    1025                 1030                 1035             


Glu Asn  Lys Lys Asn Phe Asn  Glu Tyr Lys Phe Lys  Glu Tyr Lys 
    1040                 1045                 1050             


Ser Ile  Lys Asn Phe Arg Asn  Glu Ile Ala His Phe  Asn Tyr Phe 
    1055                 1060                 1065             


Gln Lys  Thr Asn Lys Ser Leu  Leu Glu Leu Leu Asn  Asp Phe Tyr 
    1070                 1075                 1080             


Asp Ile  Phe Asp Tyr Asn Leu  Lys Tyr Gln Arg Asp  Val Gln Lys 
    1085                 1090                 1095             


Val Ile  Asn Asn Ile Phe Glu  Lys Tyr Gln Ile Val  Arg Lys Asp 
    1100                 1105                 1110             


Arg Gly  Pro Val Val Phe Tyr  Cys Lys Thr Asp Lys  Lys Leu Lys 
    1115                 1120                 1125             


Leu Ser  Glu Asn Ile Ile Pro  Lys Lys His Leu Lys  Tyr Pro Glu 
    1130                 1135                 1140             


Ile Lys  Leu Ile His Glu Lys  Tyr Val Glu Phe Phe  Lys Lys Leu 
    1145                 1150                 1155             


Phe Glu  Tyr Lys Lys 
    1160             


<210>  954
<211>  1197
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  954

Met Lys Val Thr Lys Ile Asp Gly Ile Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Arg Tyr Thr Gly Asn Phe Asn Ile Lys Asn Glu 
            20                  25                  30          


Met Lys Glu Arg Leu Glu Lys Leu Lys Glu Leu Lys Leu Ser Asn Tyr 
        35                  40                  45              


Val Lys Asn Pro Glu Asn Val Lys Asn Lys Asp Lys Asn Lys Glu Lys 
    50                  55                  60                  


Glu Thr Lys Ser Arg Arg Glu Asn Leu Lys Lys Tyr Phe Ser Glu Ile 
65                  70                  75                  80  


Ile Leu Arg Lys Lys Glu Glu Lys Tyr Leu Leu Lys Lys Thr Arg Lys 
                85                  90                  95      


Phe Lys Asn Ile Thr Glu Glu Ile Asn Tyr Asp Asp Ile Lys Lys Arg 
            100                 105                 110         


Glu Asn Gln Gln Lys Ile Phe Asp Val Leu Lys Glu Leu Leu Glu Gln 
        115                 120                 125             


Arg Ile Asn Glu Asn Asp Lys Glu Glu Ile Leu Asn Phe Asp Ser Val 
    130                 135                 140                 


Lys Leu Lys Glu Val Phe Gly Glu Asp Phe Ile Lys Lys Glu Ser Lys 
145                 150                 155                 160 


Ile Lys Ala Ile Glu Glu Ser Leu Glu Lys Asn Arg Ala Asp Tyr Arg 
                165                 170                 175     


Lys Asp Tyr Val Glu Leu Glu Asn Glu Lys Tyr Glu Asp Val Lys Gly 
            180                 185                 190         


Gln Asn Lys Arg Ser Leu Val Phe Glu Tyr Tyr Lys Asn Pro Glu Asn 
        195                 200                 205             


Arg Glu Lys Phe Lys Glu Asn Ile Lys Tyr Ala Phe Glu Asn Leu Tyr 
    210                 215                 220                 


Thr Glu Glu Asn Ile Lys Asn Leu Tyr Ser Glu Ile Glu Glu Ile Phe 
225                 230                 235                 240 


Gly Lys Val His Leu Lys Ser Lys Val Arg Asp Phe Tyr Gln Asn Arg 
                245                 250                 255     


Ile Ile Gly Glu Ser Glu Phe Ser Glu Lys Asp Glu Glu Gly Ile Ser 
            260                 265                 270         


Ile Leu Tyr Lys Gln Ile Ile Asn Ser Val Glu Lys Lys Glu Lys Phe 
        275                 280                 285             


Val Glu Phe Leu Gln Lys Val Lys Ile Lys Asp Leu Thr Arg Ser Gln 
    290                 295                 300                 


Ile Phe Tyr Lys Tyr Phe Leu Glu Asn Glu Glu Leu Asn Asp Glu Asn 
305                 310                 315                 320 


Ile Lys Tyr Val Phe Ser Tyr Phe Val Glu Ile Glu Val Asn Lys Leu 
                325                 330                 335     


Leu Lys Glu Asn Val Tyr Lys Thr Lys Lys Phe Asn Glu Gly Asn Lys 
            340                 345                 350         


Tyr Arg Val Lys Asn Ile Phe Asn Tyr Asp Lys Leu Lys Asn Leu Val 
        355                 360                 365             


Val Tyr Lys Leu Glu Asn Lys Leu Asn Asn Tyr Ile Arg Asn Cys Gly 
    370                 375                 380                 


Lys Tyr Asn Tyr His Met Glu Asn Gly Cys Val Ala Thr Ser Asp Thr 
385                 390                 395                 400 


Asn Met Lys Asn Arg Gln Thr Glu Ala Phe Leu Arg Ser Ile Leu Gly 
                405                 410                 415     


Val Ser Ser Phe Gly Tyr Phe Ser Leu Arg Asn Ile Leu Gly Val Asn 
            420                 425                 430         


Asp Asn Asp Phe Tyr Glu Ile Glu Glu Glu Leu Thr Glu Asp Glu Arg 
        435                 440                 445             


Lys Asn Glu Asn Phe Ile Leu Lys Lys Ala Lys Glu Asp Ile Thr Ser 
    450                 455                 460                 


Lys Asn Ile Phe Glu Lys Val Val Asp Lys Ser Phe Glu Lys Lys Gly 
465                 470                 475                 480 


Ile Tyr Gln Ile Lys Glu Asn Leu Lys Met Phe Tyr Gly Asn Ser Phe 
                485                 490                 495     


Asp Lys Val Asp Lys Asp Glu Leu Lys Lys Phe Phe Val Asn Met Leu 
            500                 505                 510         


Glu Ala Ile Thr Ser Val Arg His Arg Ile Val His Tyr Asn Ile Asn 
        515                 520                 525             


Thr Asn Ser Glu Asn Ile Phe Asp Phe Ser Asn Ile Glu Val Ser Lys 
    530                 535                 540                 


Leu Leu Lys Asn Ile Phe Glu Lys Glu Ile Asp Thr Arg Glu Leu Lys 
545                 550                 555                 560 


Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Gly Val Phe Asp Tyr Trp 
                565                 570                 575     


Glu Ser Trp Lys Ile Lys Lys Tyr Leu Glu Asn Ile Glu Phe Lys Phe 
            580                 585                 590         


Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys Leu Tyr Asn 
        595                 600                 605             


Arg Ile Asp Asn Leu Lys Gly Asn Asn Ala Leu Asn Leu Gly Tyr Ile 
    610                 615                 620                 


Asn Ile Pro Lys Arg Lys Glu Ala Lys Asp Ser Gln Ile Tyr Leu Leu 
625                 630                 635                 640 


Lys Asn Ile Tyr Tyr Gly Glu Phe Val Glu Lys Phe Val Asn Asp Asn 
                645                 650                 655     


Lys Asn Phe Glu Lys Ile Val Lys Glu Ile Ile Glu Ile Asn Arg Gly 
            660                 665                 670         


Ala Gly Thr Asn Lys Lys Thr Gly Phe Tyr Lys Leu Glu Lys Phe Glu 
        675                 680                 685             


Thr Leu Lys Ala Asn Thr Pro Ile Glu Tyr Leu Glu Lys Leu Gln Ser 
    690                 695                 700                 


Leu His Lys Ile Ser Tyr Asp Lys Glu Lys Ile Glu Glu Asp Lys Asp 
705                 710                 715                 720 


Ile Tyr Val Asp Phe Val Gln Lys Ile Phe Leu Lys Gly Phe Val Asn 
                725                 730                 735     


Tyr Leu Lys Lys Leu Asp Ser Leu Lys Ser Leu Asn Leu Leu Asn Leu 
            740                 745                 750         


Arg Lys Asp Glu Thr Ile Thr Asp Lys Lys Ser Phe His Asp Glu Lys 
        755                 760                 765             


Leu Lys Leu Trp Glu Asn Ser Gly Ser Asn Leu Ser Lys Met Pro Glu 
    770                 775                 780                 


Glu Ile Tyr Glu Tyr Val Lys Lys Ile Lys Ile Ser Asn Ile Asn Tyr 
785                 790                 795                 800 


Asn Asp Arg Met Ser Ile Phe Tyr Leu Leu Leu Lys Leu Ile Asp Tyr 
                805                 810                 815     


Arg Glu Leu Thr Asn Leu Arg Gly Asn Leu Glu Lys Tyr Glu Ser Met 
            820                 825                 830         


Asn Lys Asn Lys Ile Tyr Ser Gly Glu Leu Thr Ile Ile Asn Leu Val 
        835                 840                 845             


Asn Leu Asp Asn Asn Lys Val Arg Thr Asn Phe Ser Leu Glu Ala Glu 
    850                 855                 860                 


Asp Ile Gly Lys Phe Leu Lys Ser Ser Ile Thr Ile Lys Asn Ile Ala 
865                 870                 875                 880 


Gln Leu Asn Asn Phe Ser Lys Ile Phe Ala Asp Gly Glu Asn Val Ile 
                885                 890                 895     


Lys His Arg Ser Phe Tyr Asn Ile Lys Lys Tyr Gly Ile Leu Asp Leu 
            900                 905                 910         


Leu Glu Lys Met Ile Ala Arg Ala Asp Leu Lys Ile Ser Lys Glu Glu 
        915                 920                 925             


Ile Lys Lys Tyr Glu Asn Leu Gln Asn Glu Leu Lys Arg Asn Asp Phe 
    930                 935                 940                 


Tyr Lys Ile Gln Glu Gln Ile His Arg Asn Tyr Asn Gln Lys Pro Phe 
945                 950                 955                 960 


Ser Ile Lys Lys Ile Glu Asn Lys Lys Asp Phe Glu Lys Tyr Lys Lys 
                965                 970                 975     


Val Ile Glu Lys Ile Gln Asp Tyr Thr Gln Leu Lys Asn Lys Ile Glu 
            980                 985                 990         


Phe Asn Asp Leu Asn Leu Leu Gln  Ser Leu Ile Phe Arg  Ile Leu His 
        995                 1000                 1005             


Arg Leu  Ala Gly Tyr Thr Ser  Leu Trp Glu Arg Asp  Leu Gln Phe 
    1010                 1015                 1020             


Lys Leu  Lys Gly Glu Phe Pro  Glu Asp Lys Tyr Ile  Asp Glu Ile 
    1025                 1030                 1035             


Phe Asn  Ser Asp Gly Asn Asn  Asn Gln Lys Tyr Lys  His Gly Gly 
    1040                 1045                 1050             


Ile Thr  Asp Lys Tyr Ala Asn  Phe Leu Ile Glu Lys  Glu Glu Glu 
    1055                 1060                 1065             


Lys Ser  Gly Glu Ile Leu Lys  Lys Lys Gln Arg Lys  Lys Lys Ile 
    1070                 1075                 1080             


Lys Glu  Asp Leu Glu Ile Arg  Asn Tyr Ile Ala His  Phe Asn Tyr 
    1085                 1090                 1095             


Leu Pro  Asn Ala Glu Lys Ser  Ile Leu Glu Ile Leu  Glu Glu Leu 
    1100                 1105                 1110             


Arg Glu  Leu Leu Lys His Asp  Arg Lys Leu Lys Asn  Ala Val Met 
    1115                 1120                 1125             


Lys Ser  Ile Lys Asp Ile Phe  Lys Glu Tyr Gly Phe  Ile Val Glu 
    1130                 1135                 1140             


Phe Thr  Ile Ser His Thr Lys  Asn Gly Lys Lys Ile  Lys Val Cys 
    1145                 1150                 1155             


Ser Val  Lys Ser Glu Lys Ile  Lys His Leu Lys Asn  Asn Glu Leu 
    1160                 1165                 1170             


Ile Thr  Thr Arg Asn Ser Glu  Asp Leu Cys Asp Leu  Val Lys Ile 
    1175                 1180                 1185             


Met Leu  Glu Tyr Lys Lys Leu  Gln Lys 
    1190                 1195         


<210>  955
<211>  1085
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  955

Met Lys Val Thr Lys Ala Glu Lys Leu Arg Val Ala Val Ser Arg Lys 
1               5                   10                  15      


Leu Asn Asn Glu Asp Lys Arg Ala Val Leu Tyr Lys Thr Pro Asn Pro 
            20                  25                  30          


Gly Gln Thr Cys Gly Thr Val Lys Lys Gln Leu Ala Asn Arg Val Glu 
        35                  40                  45              


Arg Ala Asn Lys Leu Tyr Gly Val Phe Phe Arg Ser Asp Val Pro Glu 
    50                  55                  60                  


Thr Leu Gln Tyr His Phe Glu Glu Leu Val Thr Tyr Ala Ala Gln Ser 
65                  70                  75                  80  


Thr Ser Pro Asn Glu Phe Arg Gln Lys Ala Ser Gln Tyr Arg Glu Cys 
                85                  90                  95      


Glu Lys Lys Asp Lys Phe Gly Lys Met Arg Lys Tyr Pro Ile Phe Arg 
            100                 105                 110         


Cys Ser Tyr Ala Pro Ser Gly Lys Asn Met Lys Lys Val Met Glu Leu 
        115                 120                 125             


Tyr Val Arg Glu Arg Met Lys Asp Glu Trp Gln Ser Gln Ala Tyr Arg 
    130                 135                 140                 


Thr Ala Ala Ile Glu Ile Leu Leu Cys Ile Cys Asn Lys Asp Phe Ser 
145                 150                 155                 160 


Lys Gln Leu Ser Arg Val Asp Ala Arg Ile Phe Ala Asp Phe Tyr Asn 
                165                 170                 175     


Ala Ser Lys Ala Cys Pro Gln Pro Tyr Ile Gly Lys Ser Thr Gly Val 
            180                 185                 190         


Leu Glu Ala Ala Phe Thr Ser Val Met Lys Gln Met Ser Leu His Ala 
        195                 200                 205             


Lys Ala Asn Ala Ser Asn Lys Ile Trp Trp Leu Gln Asn Gln Leu Arg 
    210                 215                 220                 


Thr Ile Glu Leu Asn Lys Lys Ile Val Lys Ile Ser Asp Phe Lys Tyr 
225                 230                 235                 240 


Glu Tyr Ala Thr Glu Asp Arg Met Arg Ala Ile Leu Val Arg Met Arg 
                245                 250                 255     


Lys Ser Leu Lys Arg Gly Thr Asn Gly Asp Ile Ala Val Ala Leu Leu 
            260                 265                 270         


Gln Gly Ile Ala Gln Met Asn Gly Lys Thr Leu Ser Gly Val Leu Glu 
        275                 280                 285             


Glu Leu Ser Ala Asn Ser Glu Thr Lys Glu Gln Leu Ile Lys Phe Leu 
    290                 295                 300                 


Lys Ala Val His Glu Asp Tyr His Lys Thr Pro Ile Leu Lys Ala Ile 
305                 310                 315                 320 


Arg Asn Gln Asp Val Lys Val Gln Val His Glu Val Asp Pro Val Ser 
                325                 330                 335     


Pro Glu Gly Arg Ala Leu Asp Leu Ala Ser Ile Asn Val Ser Lys Gly 
            340                 345                 350         


Asn Glu Arg Lys Lys Tyr Lys Val Ala Leu Thr Gln Thr Leu Gly Asn 
        355                 360                 365             


Tyr Ala Lys Ser Pro Lys Asp Ala Thr Gln Thr Leu Lys Ala Ile Lys 
    370                 375                 380                 


Gly Val Leu Leu Asp Tyr Phe Met Trp Leu Asp Ser Asp Val Lys Ala 
385                 390                 395                 400 


Glu Phe Leu Glu Asp Asn Asn Leu Trp Lys Ile Pro Asn Arg Thr Glu 
                405                 410                 415     


Glu Tyr Phe Asp Asn Asn Phe Val Pro Ile Asp Asp Lys Lys Asp Asp 
            420                 425                 430         


Lys Ile Glu Ala Ile Glu Asp Phe Ala Ser Ile Trp Arg Gln Glu Arg 
        435                 440                 445             


Val Lys Asn Ser Arg Ile Lys Ala Arg Met Asn Tyr Val Asn Cys Gly 
    450                 455                 460                 


Lys Tyr Gln Gln Leu Ile Lys Gln Glu Thr Asp Asp Phe Arg Ile Cys 
465                 470                 475                 480 


Trp Ile Ser Tyr Ala Lys Asp Phe Val Glu Lys Asn Tyr Val Ser Lys 
                485                 490                 495     


Asn Arg Gln Phe Thr Gln Gly Asp Cys Phe Ser Thr Lys Met Leu Leu 
            500                 505                 510         


Glu Cys Trp Lys Glu Ile Ile Arg Phe Ile Cys Gly Lys Tyr Ile Asp 
        515                 520                 525             


Ile Gly Lys Ala Val Tyr His Phe Ala Met Pro Glu Thr Met Asn Ala 
    530                 535                 540                 


Arg Asp Ser Leu Ala Tyr Gly Val Leu Gly Glu Lys Tyr Lys Glu Gly 
545                 550                 555                 560 


Ile Ser Ser Phe Asp Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln 
                565                 570                 575     


Arg Asp Ile Ala Lys Ala Ala Val Ala Ala Ile His Ala Phe Ser Gly 
            580                 585                 590         


Ser Val Ile Asp Asp Lys Lys Pro Val Glu Asp Ile Leu Phe Ile Lys 
        595                 600                 605             


Asp Glu Glu Leu Gln Glu His Ala Lys Ala Asp Asp Val Ile Val Lys 
    610                 615                 620                 


Gln Ile Leu Arg Phe Tyr Gly Gly Phe Ser Ser Val Glu Gly Arg Glu 
625                 630                 635                 640 


Lys Leu Glu Gly Met Ala Leu Ala Lys Glu Val Leu Ser Gln Leu Lys 
                645                 650                 655     


Ala Ile Arg Asn Glu Asn Phe His Phe Thr Gln Gly Lys Arg Lys Asn 
            660                 665                 670         


Val Glu Glu Asn Ile Pro Leu Thr Lys Ala Leu Trp Glu Asn Glu Glu 
        675                 680                 685             


Lys Val Tyr Arg Gln Thr Val Lys Glu Thr Tyr Tyr Ser Asn Asn Val 
    690                 695                 700                 


Ser Met Phe Tyr Ser Gln Glu Val Ile Gln Lys Leu Val Ala Glu Leu 
705                 710                 715                 720 


Tyr Gln Asn Asn Asn Val Ala Glu Ala Gln Ile Pro Ala Phe Arg Thr 
                725                 730                 735     


Ile Trp Lys Arg Lys Asp Leu Pro Glu Tyr Ile Gly Ser Leu Asn Ile 
            740                 745                 750         


Ser Trp Asp Lys Thr Glu Pro Lys Gln Val Ile Tyr Glu Gly Ala Leu 
        755                 760                 765             


Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Lys Ser Gly 
    770                 775                 780                 


Glu Ala Lys Lys Leu Phe Phe Asp Ala Val Met Asp Asn Ala Thr Glu 
785                 790                 795                 800 


Met Glu Lys Ser Ser Asn Ala Asp Ser Arg Asn Gln Glu Lys Lys Ala 
                805                 810                 815     


Leu Ala Asn Ala Gly Lys Asn Phe Arg Asp Tyr Val Asn Gly Leu Asn 
            820                 825                 830         


Ala Ser Thr Leu Gly Glu Val Cys Gln Phe Ile Gln Asn Glu Tyr Asn 
        835                 840                 845             


Gln Gln Asn Arg Gly Lys Gln Glu Gln Glu Ile Tyr Lys His Phe Lys 
    850                 855                 860                 


Met Leu Leu Pro Ile Cys Met Arg Lys Ala Phe Gln Arg Tyr Ile Asp 
865                 870                 875                 880 


Glu Lys His Ser Phe Ile Lys Lys Pro Gly Glu Leu Pro Gln Thr Thr 
                885                 890                 895     


Glu Asp Tyr Leu Glu Asn Val Lys Val Ala Cys Pro Glu Lys Lys Ile 
            900                 905                 910         


Lys Leu Gly Arg Trp Phe Thr Phe Ala His Phe Ile His Pro Arg Glu 
        915                 920                 925             


Leu Asn Phe Leu Ile Gly Asp Phe Lys Asn Tyr Ile Gln Tyr Arg Glu 
    930                 935                 940                 


Asp Val Leu Arg Arg Ser Glu His Ala Gly Gln Phe Ser Asp Thr Thr 
945                 950                 955                 960 


Glu Arg Asp Gly Glu Lys Ala Val Val Asp His Ala Val Gln Lys Ala 
                965                 970                 975     


Lys Asp Ile Leu Gly Val Leu Glu Phe Val Arg His Ile Ser Gly Arg 
            980                 985                 990         


Val Ser Asn Glu Phe Thr Asp Tyr  Tyr Ala Asp Arg Ala  Glu Tyr Asp 
        995                 1000                 1005             


Glu Tyr  Met Ala Lys Tyr Phe  Glu Pro Asp Val Gln  Ile Glu Gln 
    1010                 1015                 1020             


Tyr Asp  Leu Tyr Gly Asp Ala  Lys Asn Ala Lys Val  Ile Arg Asn 
    1025                 1030                 1035             


Ile Ser  Ile Asn Lys Tyr Lys  Glu Lys Phe Arg Leu  Lys Arg Ile 
    1040                 1045                 1050             


Pro Ser  Glu Tyr Thr Leu Ser  Leu Glu Glu Leu Ala  Glu Cys Ile 
    1055                 1060                 1065             


Pro Asp  Glu Arg Gly Arg Asp  Glu Ala Asp Ser Glu  Arg Ile Ala 
    1070                 1075                 1080             


Asp Ala  
    1085 


<210>  956
<211>  1152
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  956

Met Cys Met Lys Ile Thr Lys Ile Asp Gly Ile Ser His Lys Lys Tyr 
1               5                   10                  15      


Lys Glu Lys Gly Lys Leu Ile Lys Ser Asn Glu Ile Glu Lys Asp Ile 
            20                  25                  30          


Thr Glu Glu Arg Phe Asn Asp Ile Glu Ala Lys Thr Thr Glu Leu Phe 
        35                  40                  45              


Gln Lys Thr Leu Asp Phe Tyr Val Lys Asn Tyr Glu Asn Ser Glu Asp 
    50                  55                  60                  


Gln Asn Lys Glu Arg Arg Glu Lys Ala Lys Asn Tyr Phe Ser Lys Val 
65                  70                  75                  80  


Lys Ile Leu Val Asp Asn Lys Lys Ile Thr Ile Cys Asn Glu Asn Thr 
                85                  90                  95      


Glu Lys Met Glu Ile Glu Asp Phe Asn Glu Tyr Asp Val Arg Asn Arg 
            100                 105                 110         


Lys Phe Phe Asn Val Leu Asn Lys Ile Leu Asn Arg Glu Asn Cys Thr 
        115                 120                 125             


Glu Glu Asp Leu Glu Val Phe Glu Asn Asp Leu Gln Lys Arg Ile Gly 
    130                 135                 140                 


Arg Ile Lys Ser Ile Lys Asn Ser Leu Glu Glu Asn Lys Ala His Phe 
145                 150                 155                 160 


Lys Lys Glu Ser Ile Asn Asn Asn Ile Asn Tyr Asp Lys Val Lys Gly 
                165                 170                 175     


Asn Asn Lys Arg Ser Ile Phe Tyr Glu Tyr Tyr Lys Asn Ser Leu Lys 
            180                 185                 190         


His Gln Glu Tyr Ile Asn Asn Ile Phe Glu Ala Phe Asp Lys Leu Tyr 
        195                 200                 205             


Ser Asn Ser His Glu Ala Met Asn Asn Leu Phe Ser Glu Ile Thr Lys 
    210                 215                 220                 


Asp Ser Lys Asp Arg Asn Ile Arg Lys Ile Arg Glu Ala Tyr His Glu 
225                 230                 235                 240 


Ile Leu Asn Lys Asn Lys Thr Glu Phe Gly Glu Glu Leu Tyr Lys Lys 
                245                 250                 255     


Ile Gln Asp Asn Arg Asn Asn Phe Asp Lys Leu Leu Glu Ile Glu Pro 
            260                 265                 270         


Glu Ile Lys Glu Leu Thr Lys Ser Gln Ile Phe Tyr Lys Tyr Tyr Ile 
        275                 280                 285             


Asp Lys Val Asn Leu Asp Glu Thr Ser Ile Lys His Cys Phe Cys His 
    290                 295                 300                 


Leu Val Glu Ile Glu Val Asn Gln Leu Leu Lys Asn Tyr Val Tyr Ser 
305                 310                 315                 320 


Lys Arg Asn Ile Asn Lys Glu Lys Leu Glu Asn Ile Phe Glu Tyr Cys 
                325                 330                 335     


Lys Leu Arg Asn Leu Val Lys Asn Lys Leu Val Asn Lys Leu Asn Asn 
            340                 345                 350         


Tyr Ile Arg Asn Cys Gly Lys Tyr Asn Ala Tyr Ile Ser Asn Asn Asp 
        355                 360                 365             


Val Val Val Asn Ser Glu Lys Ile Ser Glu Ile Arg Thr Lys Glu Ala 
    370                 375                 380                 


Phe Leu Arg Ser Ile Ile Gly Val Ser Ser Ser Ala Tyr Phe Ser Leu 
385                 390                 395                 400 


Arg Asn Ile Leu Asn Thr Asp Asn Thr Gln Asp Ile Thr Asn Lys Val 
                405                 410                 415     


Asp Lys Glu Val Asp Lys Leu Tyr Gln Glu Asn Lys Lys Ile Glu Leu 
            420                 425                 430         


Glu Glu Ile Leu Lys Leu Phe Phe Gly Asn Tyr Phe Asp Ile Asn Asn 
        435                 440                 445             


Gln Gln Glu Ile Lys Val Phe Leu Met Asn Ile Asp Lys Ile Ile Ser 
    450                 455                 460                 


Ser Ile Arg His Glu Ile Ile His Phe Lys Met Glu Thr Asn Ala Gln 
465                 470                 475                 480 


Asn Ile Phe Asp Phe Asn Asn Val Asn Leu Gly Asn Thr Ala Lys Asn 
                485                 490                 495     


Ile Phe Ser Asn Glu Ile Asn Glu Glu Lys Ile Lys Phe Lys Ile Phe 
            500                 505                 510         


Lys Gln Leu Asn Ser Ala Asn Val Phe Asp Tyr Leu Ser Asn Lys Asp 
        515                 520                 525             


Ile Thr Glu Tyr Met Asp Lys Val Val Phe Ser Phe Thr Asn Arg Asn 
    530                 535                 540                 


Val Ser Phe Val Pro Ser Phe Thr Lys Ile Tyr Asn Arg Val Gln Asp 
545                 550                 555                 560 


Leu Ala Asn Ser Leu Glu Ile Lys Glu Trp Lys Ile Pro Asp Glu Ser 
                565                 570                 575     


Glu Gly Lys Asp Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly 
            580                 585                 590         


Lys Phe Leu Asp Lys Phe Leu Asn Glu Glu Asn Gly Ile Phe Ile Ser 
        595                 600                 605             


Ile Lys Asp Lys Ile Ile Glu Leu Asn Lys Asn Gln Asn Glu Asp Lys 
    610                 615                 620                 


His Cys Lys Phe Lys Lys Phe Glu Ser Val Asn Glu Lys Asn Pro Lys 
625                 630                 635                 640 


Lys Tyr Leu Glu Ile Ile Gln Ser Leu Tyr Met Ile Asn Ile Glu Lys 
                645                 650                 655     


Ile Asn Ser Glu Arg Lys Asn Val Phe Leu Asp Phe Ile Gln Arg Ile 
            660                 665                 670         


Phe Leu Lys Gly Phe Phe Glu Phe Ile Lys Asn Asp Tyr Asn Tyr Leu 
        675                 680                 685             


Leu Glu Leu Lys Lys Val Gln Asp Lys Lys Asn Ile Phe Asp Ser Lys 
    690                 695                 700                 


Met Ser Glu Tyr Ile Ala Gly Glu Lys Thr Leu Glu Tyr Met Glu Glu 
705                 710                 715                 720 


Ile Asn Glu Ile Ile Gln Asp Ile Lys Ile Thr Glu Ile Asp Lys Ile 
                725                 730                 735     


Leu Asn Gln Thr Asp Lys Ile Asn Cys Phe Tyr Leu Leu Leu Lys Leu 
            740                 745                 750         


Leu Asn Tyr Lys Glu Ile Thr Glu Leu Lys Gly Asn Leu Glu Lys Tyr 
        755                 760                 765             


Gln Ile Leu Ser Lys Thr Asn Val Tyr Glu Lys Glu Leu Met Leu Leu 
    770                 775                 780                 


Asn Ile Val Asn Leu Asp Asn Asn Lys Val Lys Ile Glu Asn Phe Lys 
785                 790                 795                 800 


Ile Ser Ala Glu Glu Ile Gly Lys Phe Ile Glu Lys Ile Asn Ile Glu 
                805                 810                 815     


Glu Ile Asn Lys Lys Ile Lys Thr Phe Glu Glu Leu Arg Asn Phe Glu 
            820                 825                 830         


Lys Gly Glu Asn Thr Gly Glu Tyr Tyr Asn Ile Tyr Ser Asp Asp Lys 
        835                 840                 845             


Asn Ile Lys Asn Ile Arg Asn Leu Tyr Asn Ile Lys Lys Tyr Gly Met 
    850                 855                 860                 


Leu Asp Leu Leu Glu Lys Ile Ser Glu Lys Thr Asn Tyr Cys Ile Lys 
865                 870                 875                 880 


Lys Lys Asp Leu Glu Glu Tyr Ser Lys Leu Arg Lys Gln Leu Glu Asp 
                885                 890                 895     


Lys Lys Lys Glu Asn Glu Lys Ile Glu Asp Glu Lys Thr Asn Phe Tyr 
            900                 905                 910         


Lys Ile Gln Glu Tyr Leu His Ser Lys Tyr Gln Gln Glu Pro Lys Lys 
        915                 920                 925             


Ile Leu Trp Lys Asn Asn Lys Asn Asp Tyr Glu Lys Tyr Lys Lys Ser 
    930                 935                 940                 


Ile Glu Asn Ile Glu Lys Tyr Val His Leu Lys Asn Lys Ile Glu Phe 
945                 950                 955                 960 


Asn Glu Leu Asn Leu Leu Gln Ser Leu Leu Leu Lys Ile Leu His Arg 
                965                 970                 975     


Leu Val Gly Phe Thr Ser Ile Trp Glu Arg Asp Leu Arg Phe Arg Leu 
            980                 985                 990         


Thr Gly Glu Phe Pro Asp Glu Leu  Asp Ile Glu Asp Ile  Phe Asp His 
        995                 1000                 1005             


Arg Lys  Arg Tyr Lys Gly Thr  Gly Gly Gly Ile Cys  Lys Lys Tyr 
    1010                 1015                 1020             


Asp Arg  Phe Ile Asn Thr Tyr  Thr Glu Tyr Lys Asn  Asn Asn Lys 
    1025                 1030                 1035             


Met Lys  Asn Val Lys Phe Ala  Asp Asn Asn Pro Val  Arg Asn Tyr 
    1040                 1045                 1050             


Ile Ala  His Phe Asn Tyr Leu  Pro Asn Pro Lys Tyr  Ser Ile Leu 
    1055                 1060                 1065             


Lys Met  Met Glu Lys Leu Arg  Lys Leu Leu Asp Tyr  Asp Arg Lys 
    1070                 1075                 1080             


Leu Lys  Asn Ala Val Met Lys  Ser Ile Lys Asp Ile  Leu Glu Glu 
    1085                 1090                 1095             


Tyr Gly  Phe Lys Ala Glu Phe  Ile Ile Asn Ser Asp  Lys Glu Ile 
    1100                 1105                 1110             


Ile Leu  Asn Pro Val Lys Ser  Val Glu Ile Ile His  Leu Gly Lys 
    1115                 1120                 1125             


Glu Asp  Leu Lys Ser Arg Arg  Asn Ser Glu Asp Leu  Cys Lys Leu 
    1130                 1135                 1140             


Val Lys  Ala Met Leu Glu Tyr  Ser Glu 
    1145                 1150         


<210>  957
<211>  1185
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  957

Met Arg Ile Ile Lys Pro Tyr Gly Arg Ser Val Val Glu Lys Ala Gly 
1               5                   10                  15      


Pro Gly Arg Leu Ala Arg Ala Val Ser Leu His Pro Asp Pro Ala Arg 
            20                  25                  30          


Gly Val Glu Leu Asp Asn Arg Lys Ser Val Val Glu Phe Ala Ala Ser 
        35                  40                  45              


His Asp Arg Leu Val Ile Ala Gln Trp Ile Ser Thr Ile Asp Lys Ile 
    50                  55                  60                  


Ala Arg Lys Pro Val Gly Glu Ala Ala Ala Thr Pro Gln Gln Ala Glu 
65                  70                  75                  80  


Phe Arg Arg Arg Leu Gly Asp Ala Ala Trp Thr Leu Ile Glu Arg Arg 
                85                  90                  95      


Ala Leu Leu Thr Gly Leu Asn Asp Pro Ala Val Lys Ala Arg Leu Arg 
            100                 105                 110         


Arg Leu Trp Glu Phe Lys Ile Ala Pro Tyr Lys Thr Ala Arg Ala Val 
        115                 120                 125             


Ala Lys Thr Gly Thr Arg Pro Pro Arg Leu Lys Gly Trp Trp Phe Arg 
    130                 135                 140                 


Arg Phe Ala Gly Asp Val Glu Glu Val Asp Lys Val Asp Ala Asp Ala 
145                 150                 155                 160 


Val Ala Leu Ala Ile His Glu His Leu Tyr Ser Ala Gln Tyr Gln Met 
                165                 170                 175     


Arg Val Asp Asp Arg Thr Arg Leu Ser Gly Leu Ile Ala Ala Arg Ala 
            180                 185                 190         


Glu Ser Ile Ala Gly Asn Val Leu Gln Pro His Ala Ala Ala Arg Asp 
        195                 200                 205             


Lys Asp Gly Gly Trp Ser Glu Asp Asp Gln Arg Arg Tyr Ala Ala Ala 
    210                 215                 220                 


Gly Asp Val Ala Arg Glu Ile Arg Ser Ala Ala Glu Ala Arg Glu Arg 
225                 230                 235                 240 


Gly Asp Gly Lys Ile Gly Pro Arg Arg Val Thr Ser Glu Val Ala Gly 
                245                 250                 255     


Ala Ala Leu Phe Glu His Tyr Ala Arg Leu Phe Arg Gly Ala Asp Gly 
            260                 265                 270         


Lys Ala Met Gly Val Ala Gln Ala Arg Asp Gln Glu Ser Gly Leu Phe 
        275                 280                 285             


Asn Leu His Met Ala Val Lys Asp Cys Tyr Ala Arg Ile Leu Lys Gly 
    290                 295                 300                 


His Gly Lys Asp Leu Ala Lys His Gly Glu Gly Arg Arg Arg Val Ser 
305                 310                 315                 320 


Thr Leu Leu Pro Pro Thr Ser Val Asp Leu Phe Arg Leu Leu Asp Ala 
                325                 330                 335     


Met Leu Asp Asn Arg Asp Leu Asn Ala Leu Val Arg Leu Gly Lys Val 
            340                 345                 350         


Ile His Tyr Glu Ser Ala Gly Ala Gly Val Asp Arg Pro Ala Asp Val 
        355                 360                 365             


Val Asp His Trp Pro Ala Asp Val Ala Asp Ser Asp Tyr Trp Thr Ser 
    370                 375                 380                 


Asp Gly Gln Ala Arg Ile Lys Arg Asn Glu Ala Leu Val Arg Val Trp 
385                 390                 395                 400 


Arg His Val Leu Ala Leu Ala Ser Arg Thr Leu Thr Asp Trp Ala Asp 
                405                 410                 415     


Pro Lys Gly Met Ile Gly Gly Asp Ile Leu Leu Lys Asp Ser Val Glu 
            420                 425                 430         


Thr Ala Ile Ala Asn Phe Asp Ala Glu Ser Tyr Lys Arg Lys Ile Glu 
        435                 440                 445             


Val Leu Phe Gly Gly Arg Ala Ala Leu Phe Asp Gly Asp Gly Asp Glu 
    450                 455                 460                 


Ala Phe Glu Lys Asp Val Leu Arg Phe Ala Leu His Gly Val Ala Ala 
465                 470                 475                 480 


Leu Arg Asn Ala Ala Phe His Phe Lys Gly Val Gly Gly Phe Ala Glu 
                485                 490                 495     


Ala Leu Lys Thr Leu Gly Pro Arg Gln Asp Pro Arg Val Thr Ala Ala 
            500                 505                 510         


Val Asp Gly Leu Trp Arg Thr Asp Glu Glu Gly Arg Gly Arg Arg Leu 
        515                 520                 525             


Leu Ala Thr Met Arg Gly Ala His Phe Glu Ser Phe Phe Asp Gln Arg 
    530                 535                 540                 


Gln Asn Arg Arg Leu Ala Gln Ala Leu Ser Arg Ala Ser Glu Glu Ser 
545                 550                 555                 560 


Leu Pro Leu Pro Arg Phe Ala Val Met Leu Arg Arg Ala Glu Asn Ala 
                565                 570                 575     


Trp Asp Arg Leu Gly Leu Pro Lys Thr Ala Asn Arg Ala Asp Leu Glu 
            580                 585                 590         


Ala Pro Ala Arg His Cys Gln Tyr Val Ala Leu Lys Leu Leu Tyr Glu 
        595                 600                 605             


Arg Pro Phe Arg Ala Trp Leu Ala Glu Arg Asp Ala Ala Thr Leu Asn 
    610                 615                 620                 


Arg Phe Ile Val Cys Ala Val Glu Arg Ala Thr Lys Ala Ala Arg Met 
625                 630                 635                 640 


Leu Asn Pro Gly Ala Ser Arg Glu Leu Ala Glu Ala Ile Thr Ala Lys 
                645                 650                 655     


Ala Ala Asp Leu Gly Arg Leu Gly Asn Asp Asp Ser Val Glu Asp Phe 
            660                 665                 670         


Phe Phe Arg Leu Ser Ala Glu Thr Ala Gly Glu Ala Arg Val Gln Arg 
        675                 680                 685             


Gly Tyr Glu Ser Asp Ala Glu Asn Ala Arg Ala Gln Ala Ser His Ile 
    690                 695                 700                 


Glu Asn Leu Lys Ala Asp Leu Val Ala Leu Ala Phe Arg Asp Tyr Leu 
705                 710                 715                 720 


Gln Lys Ala Asp Phe Glu Phe Ala Leu Lys Leu Arg Gly Asp Glu Pro 
                725                 730                 735     


Leu Pro Thr Lys Pro Met Cys Ala Leu Asp Glu Ala Asp Phe Val Glu 
            740                 745                 750         


Gly Glu Ala Ser Ser Ala Glu Pro Pro Cys Glu Leu Tyr Phe Leu Leu 
        755                 760                 765             


His Leu Val Pro Val Asp Glu Val Gly Lys Leu Leu His Gln Leu Arg 
    770                 775                 780                 


Lys Trp Gln Ile Leu Ala Pro Pro Ala Pro Ala Ala Thr Gly Gly Pro 
785                 790                 795                 800 


Thr Thr Ala Ala Thr Val Ala Glu Ile Arg Leu Ala Leu Glu Leu Tyr 
                805                 810                 815     


Leu Asp Met His Asp Ala Lys Phe Glu Gly Gly Ala Ala Leu Val Gly 
            820                 825                 830         


Val Glu Pro Phe Lys Arg Leu Phe Glu Gly Asp Gly Leu Phe Gly Arg 
        835                 840                 845             


Ile Phe Glu Arg Pro Ala Gly Asp Arg Pro Gly Ala Glu Asp Asp Arg 
    850                 855                 860                 


Arg Leu Pro Arg Arg Gly Leu Arg Glu Ile Met Arg Phe Gly His Leu 
865                 870                 875                 880 


Arg Pro Leu Leu Pro Ile Phe Asp Lys Gln Pro Ile Arg Ala Asp Glu 
                885                 890                 895     


Val Ala Ala Tyr Leu Asp Ala Glu Gln Val Pro Asp Gly Gly Lys Ser 
            900                 905                 910         


Glu Ile Ala Arg Arg Gln Glu Arg Arg Glu Ala Leu His Glu Lys Trp 
        915                 920                 925             


Ala Arg Arg Arg Arg Glu Phe Ser Asp Asp Asp Arg Arg Ala Tyr Glu 
    930                 935                 940                 


Glu Ala Leu Arg Phe Val Glu Glu His Arg His Arg Ala Ala Arg Val 
945                 950                 955                 960 


Thr Leu Thr Asp His Val Arg Leu His Arg Leu Leu Met Ala Val Leu 
                965                 970                 975     


Gly Arg Leu Val Asp Tyr Ser Gly Leu Trp Glu Arg Asp Leu Tyr Phe 
            980                 985                 990         


Val Ala Leu Ala Leu Ile His Gln  Ala Gly Arg Arg Leu  Asp Glu Ile 
        995                 1000                 1005             


Phe Ala  Ala Asp Gly Leu Ala  Met Leu Arg Glu Gly  Arg Val Val 
    1010                 1015                 1020             


Glu Ala  Leu Arg Lys Leu Ala  Asp Ile Asp Ala Ala  Arg Ala Ile 
    1025                 1030                 1035             


Ala Ala  Glu Val Lys Arg Arg  Phe Asp Gly Ala Pro  Asp Ala Ala 
    1040                 1045                 1050             


Ser Arg  Val Val Lys Ile Arg  Asn Ala Phe Ala His  Phe Asn Met 
    1055                 1060                 1065             


Leu Arg  Pro Lys Arg Gly Gly  Ala Thr Ala Ala Leu  Asp Leu Thr 
    1070                 1075                 1080             


Ala Ala  Val Asn Asp Gly Arg  Glu Leu Met Ala Tyr  Asp Arg Lys 
    1085                 1090                 1095             


Leu Lys  Asn Ala Val Ser Arg  Ser Ile Ala Glu Leu  Leu Glu Arg 
    1100                 1105                 1110             


Glu Gly  Leu Ala Val Ala Trp  Ser Val Asn Glu His  Arg Leu Glu 
    1115                 1120                 1125             


Ala Thr  Arg Val Ser Thr Arg  Gln Ala Ser His Leu  Ala Asn Ser 
    1130                 1135                 1140             


Gly Leu  Arg Glu Asp Leu His  Gly Ala Gly Tyr Val  Ala Thr Val 
    1145                 1150                 1155             


Ala Glu  Leu Phe Gly Arg Thr  Ala Ala Lys Pro Ala  Ala Pro Leu 
    1160                 1165                 1170             


Ala Arg  Arg Glu Asn Arg Thr  Ala Arg Gly Gly Arg  
    1175                 1180                 1185 


<210>  958
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  958

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Pro Gly Thr Asp Thr 
            20                  25                  30          


Ile Gly Leu Lys Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Asp Lys Pro Lys Lys 
    50                  55                  60                  


Trp Lys Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Glu Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Ser Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Met Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Tyr Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ser Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Gln Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Phe 
            660                 665                 670         


Ile Arg Lys Asn Phe Pro Glu Asp Ile Ser Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val Tyr Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Asp Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Asp Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asn  Ser Glu Lys Lys Glu  Ala Tyr Gln Lys Ile  Glu Val Asn 
    1100                 1105                 1110             


Gly Asp  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Val  Tyr Ala Pro Asp Glu  Lys Gly Asp 
    1130                 1135                 1140             


Ile Leu  Lys Glu Gln Cys Thr  Lys Gly Gly Ala Gly  Gly Lys Ile 
    1145                 1150                 1155             


Ser Ala  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Lys Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Lys Gln 
    1250                 1255                 1260             


Thr Thr  Ser Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Ser Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Lys  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Val Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Gly Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Pro Asn 
    1370                 1375                 1380         


<210>  959
<211>  1340
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  959

Val Pro Pro Ala Phe Pro Gly Glu Val Phe Glu Ala Ser Gly Glu Ile 
1               5                   10                  15      


Gly Gly Gln Ala Leu Arg Gln Pro Gly Leu Ser Pro Trp Arg Glu Arg 
            20                  25                  30          


Lys Asp Gln Arg Asn Arg Ala Cys Gln Pro Pro Gly Arg Arg Pro Tyr 
        35                  40                  45              


Ala Ala Thr Arg Asn Ser Gly Arg Ser Arg Asp Asp Met Leu Ile Val 
    50                  55                  60                  


Lys Pro Tyr Gly Arg Ser Glu Ala Ala Arg Gly Glu Asp Gly Ala Leu 
65                  70                  75                  80  


Arg Arg Gln Leu Arg Leu Arg Pro Asp Asp Ala Gly Pro Leu Ala Leu 
                85                  90                  95      


Pro Glu Phe Ala Glu Thr His Pro Glu Leu Val Val Ala Gln Trp Ile 
            100                 105                 110         


Ser Ala Ile Asp Lys Ile Ala Ala Lys Pro Arg Gly Gln Ala Lys Pro 
        115                 120                 125             


Thr Pro Glu Gln Arg Arg Leu Arg Asn Met Leu Gly Gly Ala Ala Trp 
    130                 135                 140                 


Glu Leu Leu Ala Arg Lys His Phe Pro Gln Asp Arg Leu Glu Glu Leu 
145                 150                 155                 160 


Gly Lys Leu Trp Arg Arg Lys Leu His Pro Tyr Gly Asp Gly Glu Ser 
                165                 170                 175     


Asp His Ala Ser Gly Arg Glu Lys Gly Arg Trp Tyr Ala Arg Phe Ala 
            180                 185                 190         


Gly Glu Thr Ala Pro Gly Asp Ile Gly Lys Asp Lys Ser Ala Glu Ile 
        195                 200                 205             


Ala Gly Lys Ile Glu Glu His Leu His Glu Thr Glu Tyr Arg Ile Gly 
    210                 215                 220                 


Gly Gly Arg Pro Asn Lys Arg Arg Gly Arg Ile Ala Ala Arg Ala Glu 
225                 230                 235                 240 


Ser Ile Ala Gly Asn Val Val Thr Thr Val Ser Glu Pro Pro Lys Ala 
                245                 250                 255     


Gly Trp Thr Asp Ala Asp Leu Glu Arg Tyr Arg Thr Ala Gly Asp Val 
            260                 265                 270         


Ala Ala Lys Ile Arg Ala Ala Ala Gln Ala Leu Glu Thr Glu Asn Arg 
        275                 280                 285             


Arg Val Gly Pro Arg Ala Ala Ala Glu Ala Leu Tyr Ala His Tyr Gly 
    290                 295                 300                 


Lys Leu Phe Ala Gly Gly Asp Gly Ala Ala Leu Ala Val Ala Lys Ala 
305                 310                 315                 320 


Arg Glu Arg Glu Pro Gly Leu Phe Ala Leu His Val Ala Val Arg Glu 
                325                 330                 335     


Thr Tyr Thr Arg Ile Leu Lys Asn His Gly Lys Asp Arg Gln Glu His 
            340                 345                 350         


Gly Ala Arg Arg Arg Lys Val Ser Ala Leu Leu Pro Gly Asp Met Glu 
        355                 360                 365             


Ala Leu Phe Arg Leu Ala Gly Ala Met Gly Arg Asn Arg Asp Leu Asn 
    370                 375                 380                 


Ala Leu Val Arg Leu Gly Lys Leu Val His Tyr Glu Ala Ala Pro Ala 
385                 390                 395                 400 


Pro Glu Ala Glu Ser Ala Thr Gly Asp Glu Pro Val Tyr Ala Val Asp 
                405                 410                 415     


Arg Trp Pro Gly Asp Asp Ala Ile Arg Arg Ser Arg Tyr Arg Thr Ser 
            420                 425                 430         


Ala Gly Gln Ala Glu Ile Lys Arg Asn Glu Ala Phe Val Arg Ile Trp 
        435                 440                 445             


Arg Gly Ala Gly Ala Leu Ala Gln Arg Thr Leu Thr Asp Trp Ala Asp 
    450                 455                 460                 


Pro Glu Gly Asp Ile Asp Arg Asp Ile Leu Gly Gly Pro Glu Ile Glu 
465                 470                 475                 480 


Lys Ala Cys Gly Ala Glu Phe Asn Glu Asn Ala Tyr Arg Ala Lys Leu 
                485                 490                 495     


Pro Ile Leu Phe Gly Ser Arg Ala Glu Leu Phe Asp Asp Ala Glu Gly 
            500                 505                 510         


Pro Gly Ile Leu Arg Leu Ala Leu Glu Gly Trp Thr Gly Leu Arg Asn 
        515                 520                 525             


Gly Ser Phe His Phe Lys Gly Arg Ala Gly Phe Ala Arg Ala Leu Arg 
    530                 535                 540                 


Ala Gly Leu Ala Gly Gly Glu Pro Ser Glu Ala Val Ala Ala Leu Val 
545                 550                 555                 560 


Gly Arg Asp Ala Ala Glu Arg Arg Ala Arg Leu Leu Ala Ser Leu Arg 
                565                 570                 575     


Ala Ala His Val Glu Tyr Cys Tyr Thr Gln Glu Gln Leu Gly Ala Leu 
            580                 585                 590         


Phe Asp Ala Leu Ala Asn Gly Ala Pro Ala Val Ser Pro Leu Pro Arg 
        595                 600                 605             


Phe Arg Arg Val Leu Ala Arg Ala Glu Asn Ala Trp Arg Arg Gly Lys 
    610                 615                 620                 


Phe Arg Leu Arg Leu Pro Gly Pro Glu Asn Arg Arg Asp Met Glu Ala 
625                 630                 635                 640 


Ser Pro Gly Arg Leu Ala Arg Tyr Ile Val Leu Lys Thr Leu Tyr Glu 
                645                 650                 655     


Arg Ala Phe Pro Arg Trp Leu Glu Ala Gln Glu Ala Glu Thr Leu Asn 
            660                 665                 670         


Gly Trp Ile Gly Arg Ala Ala Asp Arg Ala Thr Ala Ala Ala Arg His 
        675                 680                 685             


Ile Asn Lys Asp Glu Glu Ala Ala Ala Arg Met Ala Gly Leu Val Arg 
    690                 695                 700                 


Leu Ala Asp Asp Glu Arg Ile Ala Asp Phe Thr Asp Arg Leu Ala Ala 
705                 710                 715                 720 


Gln Thr Ala Ser Glu Tyr Arg Val Gln Arg Gly Tyr Asp Ser Asp Pro 
                725                 730                 735     


Leu Ala Ala Arg Lys Gln Ala Lys His Ile Glu Asp Leu Arg Cys Asp 
            740                 745                 750         


Val Val Gly Gln Ala Phe Glu Ala Tyr Leu Ala Asp Glu Ala Arg Lys 
        755                 760                 765             


Leu Thr Trp Met Met Asn Asp Pro Pro Gly Gly Pro Leu Pro Asp Glu 
    770                 775                 780                 


Lys Lys Ala Ser Leu Glu Thr Ala Ala Pro Pro Ala Glu Asp Ala Gly 
785                 790                 795                 800 


Thr Glu Ala Glu Glu Asp Trp Leu Ala Arg Leu Tyr Phe Leu Leu His 
                805                 810                 815     


Met Leu Pro Val Glu Thr Ala Gly Gly Leu Arg His Gln Leu Arg Lys 
            820                 825                 830         


Trp Ser Val Leu Glu Glu Lys Ala Lys Pro Gly Glu Ser Ala Pro Asp 
        835                 840                 845             


Lys Asp Val Val Ala Ile Glu Arg Ile Phe Asp Leu Tyr Leu Asp Met 
    850                 855                 860                 


His Asp Ala Arg Phe Glu Gly Gly Asp Gly Val Ala Gly Ala Glu Ala 
865                 870                 875                 880 


Leu Ser Gly Leu Phe Ala Ser Pro Ala Gln Phe Arg Arg Val Cys Pro 
                885                 890                 895     


Glu Gly Gly Ala Gly Gly Gly Ser His Val Pro Trp Arg Gly Leu Arg 
            900                 905                 910         


Glu Met Leu Arg Phe Gly Gly Gly Glu Pro Arg Leu Met Trp Ala Phe 
        915                 920                 925             


Gly Lys Trp Pro Ile Gly Ala Gly Met Val Asp Gly Leu Glu Ala Leu 
    930                 935                 940                 


Glu Ala Thr Val Ala Glu Ala His Thr Gln Arg Glu Asp Leu His Ala 
945                 950                 955                 960 


Lys Trp Ala Gly Lys Lys Gly Phe Ser Arg Lys Asp Arg Asp Asp Tyr 
                965                 970                 975     


Arg Ala Ala Leu Glu Thr Val Val Ala His Arg His Leu Ala Ala His 
            980                 985                 990         


Val Gln Leu Val Asn His Ala Arg  Leu His Arg Leu Ala  Met Ala Val 
        995                 1000                 1005             


Leu Ala  Arg Leu Ala Asp Tyr  Ala Gly Leu Trp Glu  Arg Asp Leu 
    1010                 1015                 1020             


Tyr Phe  Ala Thr Met Ala Phe  Ile Arg Leu Glu Asn  Arg Lys Pro 
    1025                 1030                 1035             


Glu Asp  Val Phe Arg Ser Lys  Gly Leu Glu Arg Leu  Arg Glu Gly 
    1040                 1045                 1050             


Arg Ile  Val Asp Ala Leu Lys  Glu Leu Lys Lys Asn  Ala Asp Gly 
    1055                 1060                 1065             


Ser Glu  Ser Ala Val Gly Thr  Ala Leu Gln Arg Leu  Phe Gly Lys 
    1070                 1075                 1080             


Gly Phe  Leu Thr Gly Gly Gly  Thr Val Ser Val Arg  Arg Asp Leu 
    1085                 1090                 1095             


Leu His  Phe Asn Met Leu Gln  Arg Lys Glu Asn Glu  Pro Phe Asn 
    1100                 1105                 1110             


Leu Thr  Thr Ala Val Asn Asp  Thr Arg Arg Leu Met  Ala Tyr Asp 
    1115                 1120                 1125             


Arg Lys  Leu Lys Asn Ala Val  Ser Arg Ser Ile Ile  Glu Leu Leu 
    1130                 1135                 1140             


Ala Arg  Glu Gly Leu Gly Leu  Ala Trp Glu Met Lys  Asp His Glu 
    1145                 1150                 1155             


Leu Ala  Gly Ala Thr Leu Glu  Ser Arg Gln Ala Val  His Leu Gly 
    1160                 1165                 1170             


Gly Ala  Lys Val Asp Arg Gly  Pro Ile Thr Glu Asp  Leu His Gly 
    1175                 1180                 1185             


Pro Glu  Phe Thr Ala Met Ala  Ala Ala Leu Phe Gly  Gly Glu Ala 
    1190                 1195                 1200             


Arg Ala  Ala Thr Gly Ala Ala  Glu Ala Ala Thr Gly  Arg Pro Asn 
    1205                 1210                 1215             


Arg Arg  Glu Arg Lys Ser Gly  Gly Ala Arg Pro Arg  Ala Ala Arg 
    1220                 1225                 1230             


Pro Ala  Lys Ala Pro Pro Ala  Pro Thr Pro Arg Leu  Leu Pro Ala 
    1235                 1240                 1245             


Thr Gly  Glu Arg Val Glu Gly  Val Leu Ile Glu Glu  Lys Thr Arg 
    1250                 1255                 1260             


Lys Gly  Gly Trp Lys Ala Ala  Val Glu Thr Gly Gly  Arg Arg Ile 
    1265                 1270                 1275             


Val Gly  Asp Ile Tyr Asn Ser  Gly Glu Val Pro Pro  Asp Ala Gly 
    1280                 1285                 1290             


Pro Gly  Leu Glu Ala Glu Met  Val Val Arg Val Ala  Asn Pro Ala 
    1295                 1300                 1305             


Asn Ala  Ser Phe Leu Trp Leu  Ser Pro Asp Val Glu  Glu Arg Leu 
    1310                 1315                 1320             


Lys Lys  Gly Ala Gly Pro Arg  Arg Gly Gly Arg Pro  Ala Gly Arg 
    1325                 1330                 1335             


Arg Arg  
    1340 


<210>  960
<211>  1039
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  960

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Phe Glu Asn Lys Ser Glu Glu Gln Phe Ser Lys Gln Ser Phe Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Lys Lys Asn Gly Lys Val Arg Leu Lys Ser Asn Asp 
        35                  40                  45              


Leu Arg Lys His Val Met Asp Cys Asn Lys Asn Ala Gln Asn Leu Tyr 
    50                  55                  60                  


Asn Val Ile Asn Pro Glu Phe Asp Phe Cys Lys Asp Lys Asn Arg Lys 
65                  70                  75                  80  


Lys Val Phe Glu Asp Leu Ala Lys Asn Phe Asn Leu Val Leu Cys Ser 
                85                  90                  95      


Ala Leu Arg Ser Val Asp Thr Ser Ile Ser Asp Pro Lys Glu Arg Ala 
            100                 105                 110         


Lys Glu Glu Thr Ala Phe Ile Leu Asn Met Asp Lys Glu Gly Ile Lys 
        115                 120                 125             


Thr Lys Lys Asp Ser Met Lys Ser Glu Asn Leu Ile Val Glu Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Asp Asn Gly Thr Glu Lys Thr Lys Lys Ala Glu Ser 
145                 150                 155                 160 


Pro Glu Leu Lys Glu Gln Arg Arg Lys Glu Gln Glu Ala Glu Ile Leu 
                165                 170                 175     


Lys Met Thr Glu Glu Leu Val Leu Arg Lys Leu Lys Lys Thr Leu Arg 
            180                 185                 190         


Arg Asn Ala Thr Leu Asp Asp Glu Ser Lys Met Gln Met Thr Glu Ile 
        195                 200                 205             


Ala Ile Ser Leu Met Lys Ala Ile Cys Val His Gly Asn Ala Gly Ser 
    210                 215                 220                 


Phe Asp Pro Val Ile Leu Lys Thr Phe Phe Lys Glu Ile Asp Lys Asp 
225                 230                 235                 240 


Tyr Met Lys Asn Glu Gln Met Glu Glu Ile Val Arg Ser Ile Glu Ser 
                245                 250                 255     


Gln Ser Val Lys Val Lys Val Ala Glu Lys Asp Gly Lys Tyr Leu Leu 
            260                 265                 270         


Leu Pro Ala Asn Ala Asp His Arg Lys Lys Lys Tyr Ala Phe Glu Phe 
        275                 280                 285             


Met Arg Lys Tyr Ala Ala Ala Glu Ala Glu Gly Lys Gln Glu Leu Thr 
    290                 295                 300                 


Glu His Ile Gln Ala Leu Ile Gly Leu Tyr Leu Cys Gly Glu Ser Glu 
305                 310                 315                 320 


Tyr Gln Asp Ala Lys Asn Cys Phe Tyr Asp Met Val Glu Asn His Glu 
                325                 330                 335     


Cys Met Ser Gly Glu Ile Glu Glu Ile Cys Asn Thr Ile Glu Glu Leu 
            340                 345                 350         


Lys Asn Leu Ser Arg Gln Lys Arg Glu Glu Arg Lys Glu Ile Lys Glu 
        355                 360                 365             


Lys Ile Arg Lys Ile Glu Lys Ser Gly Lys Gly Asp Lys Arg Thr Pro 
    370                 375                 380                 


Asn Asn Asn Ser Asn Lys Ser Tyr Lys Asn Asp Lys Lys Asp Asn Asp 
385                 390                 395                 400 


Asn Lys Glu Asn Asp Ile Asn Leu Asn Glu Asn Asp Leu Lys Lys Ala 
                405                 410                 415     


Ile Glu Glu Ile Asp Lys Glu Leu Ala Lys Ile Pro Leu Glu Ile Cys 
            420                 425                 430         


Ile Asn Asn Glu Lys Leu Asn Asn Ala Val Ile Lys Thr Met Ser Val 
        435                 440                 445             


Lys Tyr Arg Ala Ala Val Lys Tyr Leu Val Ser Lys Val Lys Lys Thr 
    450                 455                 460                 


Val Leu Gly Glu Ile Lys Glu Lys Lys Asp Cys Ser Cys Ala Asp Leu 
465                 470                 475                 480 


Tyr Trp Ile Asp Tyr Ile Asp Asn Thr Val Lys Lys Leu Leu Leu Asp 
                485                 490                 495     


Ser Arg Asn Lys Gly Met Tyr Arg Tyr Glu Ile Ser Phe Leu Ser Asn 
            500                 505                 510         


His Ile Trp Lys Glu Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu 
        515                 520                 525             


Leu Gly Lys Gly Val Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Ala 
    530                 535                 540                 


Leu Glu Gly Lys Pro Val Ser Val Cys Glu Val Lys Pro Glu Tyr Arg 
545                 550                 555                 560 


Lys Gly Ile Ser Gly Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Ser 
                565                 570                 575     


Leu Asp Arg Glu Met Glu Glu Tyr Val Leu Phe Ala Val Asn Asn Phe 
            580                 585                 590         


Ala Arg Ala Ala Ala Pro Glu Asn Glu Arg Glu Lys Pro Gly His Glu 
        595                 600                 605             


Asp Val Leu Ile Met Lys Thr Ser Asp Glu Leu Ile Ala Glu Asn Lys 
    610                 615                 620                 


Lys Asn Gln Glu Pro Ile Val Leu Tyr Lys Asp Ala Asp Arg Arg Ile 
625                 630                 635                 640 


Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg Glu Lys Glu Asp Ser 
                645                 650                 655     


Phe Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr Lys Glu Ile Arg Asn 
            660                 665                 670         


Glu Leu Tyr Thr Val Arg Asn Ile Thr Phe His Tyr Thr Thr Lys Ala 
        675                 680                 685             


Glu Lys Asp Gln Ile Gln Lys His Glu Met Ala Glu Tyr Phe Phe Lys 
    690                 695                 700                 


Glu Glu Leu Ala Asp Ile Ser Gly Val Phe Arg Lys Lys Tyr Tyr Ser 
705                 710                 715                 720 


Asn Asn Val Trp Lys Phe Tyr Asp Val Glu Val Ile Asn Asp Leu Met 
                725                 730                 735     


Asp Lys Ile Tyr Ser Gly Arg Lys Tyr Arg Ala Ala Gln Ile Pro Ala 
            740                 745                 750         


Phe Asn Lys Ile Ile Ser Arg Pro Ala Leu Pro Gln Ile Ile Asn Gly 
        755                 760                 765             


Phe Val Lys Gly Asn Ser Leu Lys Lys Ile Met Asn Tyr Pro Asp Arg 
    770                 775                 780                 


Glu Ile Ile Lys Gln Tyr Trp Ser Ala Leu Phe Phe Val Leu Lys Glu 
785                 790                 795                 800 


Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Glu Asn Leu Glu Glu Asn 
                805                 810                 815     


Ile Arg Glu Arg Phe Leu Arg Val Leu Ala Arg Lys Leu Glu Glu Thr 
            820                 825                 830         


Ser Asp Ala Lys Glu Gln Lys Ala Trp Glu Ser Phe Asp Lys Arg Ile 
        835                 840                 845             


Ser Glu Ile Gly Arg Glu Arg Ser Phe Gly Glu Ile Cys Gln Gly Leu 
    850                 855                 860                 


Met Ile Glu Tyr Met Leu Gln Asn Asn Asp Ser Pro Met Val Arg Lys 
865                 870                 875                 880 


Glu Asn Ile His Lys Arg Thr Lys Ser Arg Asp Thr Gln Ile Tyr Lys 
                885                 890                 895     


His Tyr Arg Thr Leu Leu Tyr Ile Cys Ile Arg Asp Ala Phe Ile Glu 
            900                 905                 910         


Tyr Leu Lys Glu Lys Trp Gln Gly Leu Arg Glu Pro Val Leu Ile Lys 
        915                 920                 925             


Lys Glu Trp Ser Glu Glu Glu Phe Cys His Ser Asp Asn Val Glu His 
    930                 935                 940                 


Leu Ser Leu Tyr Asp His Leu Lys Asp Leu Phe His Ser Thr Ala Ser 
945                 950                 955                 960 


Gly Pro Ser Trp Tyr Ile Ala Ala His Phe Ile Asn Pro Lys Tyr Leu 
                965                 970                 975     


Asn His Leu Ile Gly Ser Ile Arg Asn Tyr Leu Gln Phe Thr Glu Asp 
            980                 985                 990         


Ile Glu Arg Arg Ala Val Ser Leu  Glu Lys Cys Val Asp  Asn Glu Arg 
        995                 1000                 1005             


Glu Glu  Lys Asn Leu Arg Tyr  Arg Asn Thr Leu Glu  Ile Leu Glu 
    1010                 1015                 1020             


Phe Val  Leu Gln Phe Cys Gly  Lys Lys Thr Lys Gly  Met Glu Asp 
    1025                 1030                 1035             


Lys 
    


<210>  961
<211>  1049
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  961

Met Lys Ala Leu Cys Asp Lys Thr Leu Thr Ala Tyr Gly Lys Ser Phe 
1               5                   10                  15      


Ala Ala Glu Glu Gly Gly Thr Thr Leu Tyr Glu Ala Ile Leu Asn Leu 
            20                  25                  30          


Ala Asn Gly Asn Ala Ile Gln Lys Ala Met Ala Glu Ala Glu Leu Lys 
        35                  40                  45              


Lys Ile Gln Lys Ala Leu Lys Lys Glu Lys Glu Asp Arg Ile Asn Arg 
    50                  55                  60                  


Val Arg Asn Ser Ile Arg Lys Asn Lys Ile Pro Leu Lys Val Asn Ala 
65                  70                  75                  80  


Asp Gly Thr Ile Ser Ala Asn Asn Asp Arg Ala Ala Trp Leu Leu Glu 
                85                  90                  95      


Leu Leu Lys Pro Val Ala Ser Glu His Asp Lys Asp Asp Arg Tyr Pro 
            100                 105                 110         


Val Leu Thr Glu Met Glu Glu Ile Val Ser Phe Asp Lys Leu Cys Glu 
        115                 120                 125             


Glu Val Arg Lys Lys Ile Gln Ser Cys Lys Ser Gly Ala Arg Ser Arg 
    130                 135                 140                 


Ala Met Leu Ala Asp Glu Ala Val Lys Glu Tyr Leu Lys Ala Leu Trp 
145                 150                 155                 160 


Glu Lys His Thr Asp Arg His Arg Asp Met Arg Tyr Tyr Phe Gln Ala 
                165                 170                 175     


Val Lys Glu Tyr Phe Asn Lys Asn Phe Pro Ile Arg Thr Lys Gln Arg 
            180                 185                 190         


Gly Ala Ser Ile Arg Gln Arg Leu Leu Met Glu Glu Thr Val Val Thr 
        195                 200                 205             


Arg Leu Leu Asn Pro Lys His Met Ala Lys Ala Val Arg Arg Lys Leu 
    210                 215                 220                 


Ile Asn Gln Ser Thr Gln Met His Ile Leu Tyr Gly Lys Leu Tyr Glu 
225                 230                 235                 240 


Tyr Cys Cys Arg Lys Gly Arg Asn Leu Pro Val Asn Ser Glu Thr Leu 
                245                 250                 255     


Gln Leu Ile Gln Val Leu Glu Ala Val Lys Lys Gln Leu Met Thr Ala 
            260                 265                 270         


Val Ser Trp Ser Val Ser Arg Leu Cys Tyr Phe Tyr Glu Phe Tyr Ile 
        275                 280                 285             


Gly Asp Ile Leu Leu Ala Gly Lys Tyr Arg Arg Asp Phe Leu Ile Lys 
    290                 295                 300                 


Gln Asn Asn Asn Arg Lys Asp Ile Gln Ala Cys Lys Glu Lys Leu Gln 
305                 310                 315                 320 


Asp Phe Phe Gln Leu Ala Glu Leu Gln Glu Lys Ile Lys Glu Ser Ala 
                325                 330                 335     


Asp Glu Asp Ile Asn Leu Thr Glu Thr Ile Thr Asn Asp Ala Leu Val 
            340                 345                 350         


Cys Asn Lys Leu Leu Glu Glu Cys Ala Phe Cys Ile Ser Lys Leu Arg 
        355                 360                 365             


Asn Asn Ile Phe His Tyr Lys Asn Leu Gly Phe Thr Gln Ala Leu Lys 
    370                 375                 380                 


His Ile Ala Asn Glu Ile Lys Lys Glu Asp Val Pro Val Leu Leu Arg 
385                 390                 395                 400 


Leu Tyr Lys Gln Asp Cys Glu Asn Leu Asn Asn Ala Phe Ala Ser Arg 
                405                 410                 415     


Ile Ser Ser Met Asn Ile Pro Leu Tyr Tyr Ser Thr Glu Phe Leu Leu 
            420                 425                 430         


Arg Ile Phe Lys Lys Gln Gly Val Glu Leu Ser Leu Tyr Ser Ala Lys 
        435                 440                 445             


Tyr Gln Met Thr Pro Ser Phe Lys Arg Val Tyr Glu Arg Gly Lys Asn 
    450                 455                 460                 


Leu Arg Leu Glu Tyr Glu Arg Glu Ser Met Arg Ser Asn Ile Ala Asn 
465                 470                 475                 480 


Glu Asp Gly Asn Asp Leu Gln Asn Gly Asn Trp Leu Arg Trp Phe Ser 
                485                 490                 495     


Gln Leu Glu Ala Gly Ile Val Asp Thr Asp Ala Gly Met Lys Gly Asp 
            500                 505                 510         


Ile Gly Asp Tyr Pro Asp Thr Ser Ala Asp Leu Gly Ile Glu Ala Glu 
        515                 520                 525             


Thr Gly Thr Asn Thr Asp Ala Gln Arg Ala Met Arg Asn Leu Leu Gln 
    530                 535                 540                 


Leu Ile Tyr Lys Tyr His Phe Leu Pro Glu Val Gln Lys Asn Glu Asn 
545                 550                 555                 560 


Ile Val Thr Asp Leu Ile Pro Lys Val Leu Glu Arg Asn Arg Lys Leu 
                565                 570                 575     


Ser Glu Ile Arg Asn Arg Ser Asn Arg Thr Tyr Asp Tyr Gly Tyr Lys 
            580                 585                 590         


Glu Ile Glu Glu Leu Tyr Lys Lys Asn Lys Gly Lys Lys Asp Ser Leu 
        595                 600                 605             


Ser Glu Leu Leu Lys Asp Leu Gln Arg Lys Val Ser Glu Thr Glu Lys 
    610                 615                 620                 


Glu Asn Gln Glu Leu Ala Arg Glu Lys Thr Asp Tyr Ala Gln Arg Phe 
625                 630                 635                 640 


Ile Leu Asp Ile Phe Ala Glu Ala Phe Ser Asn Phe Met Asp Asp Arg 
                645                 650                 655     


Tyr Glu Asp Glu Tyr Gln Glu Ile Met Asn Pro Lys Lys Asp Glu Glu 
            660                 665                 670         


Lys Ala Lys Lys Trp Ala Glu Leu Phe Thr Glu Lys Ala Asp Lys Asp 
        675                 680                 685             


Asn Arg Lys Asp Glu Pro Leu Val Leu Lys Thr Ser Phe Asp Lys Asp 
    690                 695                 700                 


Asn Ile Glu Lys Phe Leu Leu Val Leu Tyr Pro Leu Met Arg Leu Leu 
705                 710                 715                 720 


Asp Asp Lys Glu Leu Ser Glu Leu Gln Gln Gln Met Leu Arg Phe Arg 
                725                 730                 735     


Ala Ser Val Ser Gly Trp Gln Gly Ser Thr Asp Phe Asn Glu Asp Ile 
            740                 745                 750         


Ala Met Ala Glu Lys Ile Glu Glu Leu Ala Glu Leu Val Lys Leu Thr 
        755                 760                 765             


Glu Pro Glu Ser Gln Cys Ala Glu Val Ser Trp Lys Asn Arg Ala Ile 
    770                 775                 780                 


Glu Val Phe Glu Gln Phe Val Glu Gly Lys Met Ala Glu Tyr Gly Ala 
785                 790                 795                 800 


Phe Tyr Leu Gln Ser Asp Thr Leu Thr Pro Val Pro Arg Arg Asn Met 
                805                 810                 815     


Lys Glu Leu Leu Arg Ser Gly Ile Met Gly Val Phe Lys Lys Val Leu 
            820                 825                 830         


Leu Ser His Met Gln Ala Thr Lys Lys Asp Tyr Gly Val Tyr Ser Gly 
        835                 840                 845             


Glu His Trp Asn Ile Asp Asp Pro Ala Gly Asn Pro Ile Lys Ser Ala 
    850                 855                 860                 


Glu Gln Ala His Ala Leu Leu Gln Arg Leu His Asn Lys Tyr Thr Glu 
865                 870                 875                 880 


Ser Pro Ser Gln Phe Ser Tyr Glu Asp Tyr Lys Leu Tyr Asp Arg Thr 
                885                 890                 895     


Ile Arg Gln Leu Asp Glu Tyr Asn Gln Ala Lys Lys Asn Leu Ser Phe 
            900                 905                 910         


Gly Ser Leu Tyr Glu Val Cys Arg Ile Leu Leu Asp Met Leu Ser Arg 
        915                 920                 925             


Trp Val Gly Phe Val Gln Asp Trp Glu Arg Asp Met Tyr Phe Leu Leu 
    930                 935                 940                 


Leu Ala Trp Ala Lys Gln Gly Lys Leu His Asn Val Thr Glu Thr Asp 
945                 950                 955                 960 


Val Leu Glu Val Phe Asn Glu Gly Arg Val Ile Cys Lys Leu Asn Lys 
                965                 970                 975     


Lys Leu Lys Asp Gly Asp Trp His Ala Phe Ala Ser Ile Tyr Cys Asn 
            980                 985                 990         


Asn Ser Gly Glu Lys Leu Glu Phe  Leu Gln Val Arg Asn  Phe Ile Ala 
        995                 1000                 1005             


His Leu  His Leu Leu Arg Glu  Ser Glu Trp Asn Gly  Asp Glu Lys 
    1010                 1015                 1020             


Thr Gly  Cys Ser Ala Ile Glu  Asp Tyr Ile Asn Lys  Leu Arg Phe 
    1025                 1030                 1035             


Leu Leu  Ser Tyr Asp Gln Lys  Arg Met Asn Ala 
    1040                 1045                 


<210>  962
<211>  1315
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  962

Met Ile Ile Ile Lys Lys Phe Gly Arg Ser Val Ile Thr Gln Asp Lys 
1               5                   10                  15      


Asn Thr Asp Asn Lys Arg Glu Arg Glu Leu Asp Thr Ser Ala Arg Ala 
            20                  25                  30          


Lys Ala Lys Ser Gln Asn Ser Gln Val Phe Pro Phe Leu Asn Lys Lys 
        35                  40                  45              


Glu Asp Phe Ile Asn Leu Trp Ile Ser Glu Phe Asp Lys Leu Ile Tyr 
    50                  55                  60                  


Lys Pro Lys Gly Asp Asp Lys Pro Thr Lys Glu Met Tyr Thr Leu Arg 
65                  70                  75                  80  


Glu Ala Ala Gly Lys Gly Phe Leu Asn Tyr Trp Asn Gln Met Pro Met 
                85                  90                  95      


Val Ser Lys Lys Asp Gly Ala Phe Ser Asp Met Trp Met Ser Lys Val 
            100                 105                 110         


His Pro Tyr Gly Arg Gly Ile Thr Glu Phe Ser Pro Pro Leu Gln Leu 
        115                 120                 125             


Glu Lys Leu Ile Asp Gln Gly Leu Leu Ser Ala Met Gly Gly Ser Glu 
    130                 135                 140                 


Pro Leu Lys Asn Cys His Trp Asn Arg Val Thr Ser Asn Val Phe Lys 
145                 150                 155                 160 


Gly Leu Lys Val Gln Leu Asp Ile Leu Glu Ala Gln Ala Lys Asn Thr 
                165                 170                 175     


Phe Val Ile Lys Asn Lys Thr Asn Ser Lys Arg Asn Arg Pro Ala Ser 
            180                 185                 190         


Gln Asn Ile Lys Glu Phe Leu Leu Thr Asp Glu Thr Ala Phe Ile Asn 
        195                 200                 205             


Leu Trp Ile Ser Glu Phe Asp Lys Leu Ile Leu Lys Pro Gln Gly His 
    210                 215                 220                 


Asn Lys Pro Thr Glu Lys Met Tyr Asn Leu Arg Gln Gln Ala Gly Val 
225                 230                 235                 240 


Ala Phe Leu Asn Tyr Trp Lys Lys Lys Pro Leu Ile Pro Trp Ala Asn 
                245                 250                 255     


Ser Glu Ser Phe Pro Asp Lys Trp Met Leu Lys Val His Pro Tyr Gly 
            260                 265                 270         


Asp Lys Thr Ser Asn Asn Arg Ser Glu Thr Leu Ile Lys Ser Lys Trp 
        275                 280                 285             


Gly Ser Val Met Arg Ala Lys Glu Cys Leu Ser Asp Asp Gln Trp Glu 
    290                 295                 300                 


Gln Val Ala Phe Asn Val Tyr Ser His Leu Tyr Gly Asn Gln Lys Thr 
305                 310                 315                 320 


Leu Asn Gly Lys Asn Lys Glu Ile Gly Leu Ile Ala Ala Arg Ala Asn 
                325                 330                 335     


Ser Ile Lys Gln Asn Val Pro Ser Tyr Thr Leu Asp Lys Asp Asn Asn 
            340                 345                 350         


Phe Leu Ser Asp Lys Lys Asp Lys Leu Arg Tyr Ile Ala Ala Leu Arg 
        355                 360                 365             


Gly Glu Gly Ile Lys Trp Glu Glu Val Lys Asp Arg Tyr Lys Trp Lys 
    370                 375                 380                 


Glu Leu Thr Gln Leu Ile Asn Ile Glu Glu Ile Asp Ser Thr Asp Ile 
385                 390                 395                 400 


Ala Lys Arg Lys Gln His Leu Ala Glu Cys Phe Tyr Thr His His Gly 
                405                 410                 415     


Arg Ile Phe Gly Asp Ile Gln Lys Ser Lys Ile Glu Asp Lys Asp Cys 
            420                 425                 430         


Phe Leu Tyr His Ser Leu Val Lys Glu Ile Leu Phe Glu Cys Ile Glu 
        435                 440                 445             


Lys Lys Gln Asp Phe Leu Asn Asp Thr Glu Val His Gln Arg Leu Ile 
    450                 455                 460                 


Tyr Lys Glu Asn Asn Arg Ile Met Ala Thr Ala Val Ser Ile Gly Lys 
465                 470                 475                 480 


Leu Ile His Tyr Gln Gly Gly Ile Glu Ala Ile Gly Asn Lys Glu Asp 
                485                 490                 495     


Leu Val Asn Ser Lys Phe Leu Thr Asp Ala Gly Leu Thr Glu Ile Lys 
            500                 505                 510         


Gln Asn Glu Ser Phe Val Arg Gln Trp Leu Glu Leu Ile Ala Ile Ala 
        515                 520                 525             


Asn Thr Thr Leu Ser Gln Leu Val Asp Pro Asp Gly Lys His Glu Asp 
    530                 535                 540                 


Ile Phe Ala Ala Thr Ser Phe Asp Asp Ala Leu Lys Gly Leu Asn Asn 
545                 550                 555                 560 


Ile Ser Asp Phe Asp Ser Lys Phe Lys Leu Leu Phe Gly Glu Asn His 
                565                 570                 575     


Arg Leu Tyr Asp Asp Asp Thr Glu Arg Gln Lys Leu Leu Arg Ile Ile 
            580                 585                 590         


Tyr Asp Thr Ile Ser Ala Leu Arg Asn Ala Ser Phe His Phe Lys Asn 
        595                 600                 605             


Ile Gln Gly Phe Asn Lys Ala Leu Glu Asp Asn Leu Ser Thr Lys Gly 
    610                 615                 620                 


Arg Arg Gln Lys Gly Val Val Asp Lys Ile Ile Glu Tyr Thr Lys Val 
625                 630                 635                 640 


His Gln Gln Lys Gln His Glu Leu Leu Ile Ala Asp Leu Lys Ala Ala 
                645                 650                 655     


Asn Val Glu Asp Tyr Leu Ser Gln Leu Gln Leu Asp Tyr Leu Phe Glu 
            660                 665                 670         


Val Val Cys Lys Gly Glu Arg Glu Leu Leu Asp Met Pro Lys Phe Ser 
        675                 680                 685             


Lys Leu Leu Leu Arg Ala Gly Glu Ile Gly Glu Lys Ile Ile Ser Pro 
    690                 695                 700                 


Val Asn Ala Thr Ala Met Glu His Pro Ala Tyr Gln Phe Cys Phe Ile 
705                 710                 715                 720 


Ser Leu Lys Met Leu Tyr Asp Gln Asp Phe Val Asn Trp Leu Lys Lys 
                725                 730                 735     


Gln Ser Asn Lys Asn Ile Ala Ser Trp Met Asp Ser Ala Lys Thr Arg 
            740                 745                 750         


Ala Thr Asn Ala Ala Lys Lys Ile Phe Arg Asn Gly Thr Asn Ile Ser 
        755                 760                 765             


Ser Lys Met Ala Arg Leu Arg Asn Ile Val Glu Asp Glu Thr Leu Val 
    770                 775                 780                 


Glu Tyr Phe Ser Phe Ile Thr Ala Glu Thr Ala Asn Glu Phe Gln Val 
785                 790                 795                 800 


Gln Gln Gln Lys Asn Arg Tyr Gln Ser Asn Ser Ala Ser Ala Lys Glu 
                805                 810                 815     


Gln Ser Asn Phe Val Glu Gln Phe Lys Gln Asp Phe Leu Ile Tyr Ala 
            820                 825                 830         


Phe Lys Gly Tyr Ile Gly Asp Ile Lys Phe Gly Lys Leu Asp Gln Gly 
        835                 840                 845             


Glu Lys Leu Leu Lys Cys Asn Ala Lys Gly Ser Leu Leu Pro Glu Asn 
    850                 855                 860                 


Asn Arg Ser Asp Thr Gly Ala Glu Asp Ile Glu Arg Pro Trp Leu Tyr 
865                 870                 875                 880 


Leu Val Leu His Leu Val Pro Ile Glu Val Val Asn Arg Ile Thr Leu 
                885                 890                 895     


Gln Ile Lys Lys His Ser Val Leu Thr Asn Ser Thr Leu Asp Asp Thr 
            900                 905                 910         


Arg Ala Ala Tyr Thr Asp Ile His Gln Ala Phe Ser Leu Tyr Leu Gly 
        915                 920                 925             


Val His Gly Ala Ile Leu Gly Leu Gln Ser Leu Ser Asn Glu Pro Glu 
    930                 935                 940                 


Leu Gln Val Phe Phe Glu Lys Glu Ser Asp Phe Asn Asn Leu Phe Thr 
945                 950                 955                 960 


Asp Asn Gly Glu Gly Leu Val Pro Val Lys Gly Leu Arg Asp Ile Leu 
                965                 970                 975     


Arg Phe Gly Asn Leu Glu Gln Leu Lys Lys Met Phe Ser Asp Lys Lys 
            980                 985                 990         


Val Ala Ser Asp Asp Ile Thr Asn  Leu Lys Glu Tyr Leu  Glu Ala Thr 
        995                 1000                 1005             


Gly Gly  Lys Ser Lys Ile Ala  Arg Ala Gln Glu Lys  Arg Ile Glu 
    1010                 1015                 1020             


Leu His  Lys Thr Leu Thr Glu  Leu Pro Lys Arg Leu  Thr Lys Pro 
    1025                 1030                 1035             


Arg Val  Lys Gln Thr Gly Ile  Asp Thr Tyr Glu Lys  Asn Asn Asn 
    1040                 1045                 1050             


Ile Ser  Ile Ser Gly Ser Ile  Ser Glu Tyr Arg Lys  Asp Leu Lys 
    1055                 1060                 1065             


Cys Ile  Val Ser Tyr Arg Glu  Leu Lys Asn Lys Ile  Tyr Leu Tyr 
    1070                 1075                 1080             


Asn Val  Lys Gln Ala His Gln  Leu Ile Met Ala Thr  Gln Ala Arg 
    1085                 1090                 1095             


Leu Leu  Gly Tyr Ser Gln Ile  Arg Glu Arg Asp Leu  Tyr Phe Val 
    1100                 1105                 1110             


Leu Leu  Thr Gln Leu Met Leu  Arg Gly Val Thr Leu  Glu Lys Glu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Asp Lys Asp  Lys Leu Asn Ala Leu  Asp Thr Asp 
    1130                 1135                 1140             


Thr Val  Leu Asp Glu Glu Glu  Lys Lys Lys Leu Glu  Lys Gln Ile 
    1145                 1150                 1155             


Lys Pro  Glu Arg Ser Leu Lys  Asp Leu Val Glu Lys  Gly Leu Ile 
    1160                 1165                 1170             


Phe Leu  Ala Leu Asp Gln Leu  Ser Ser Ser Asp Lys  Asp Leu Lys 
    1175                 1180                 1185             


Ala Ile  His Ser Glu Ile Glu  Asp Met Phe Val Gly  Val Ser Pro 
    1190                 1195                 1200             


Asp Ser  Asp Asn Arg Asn Leu  Arg Asn Arg Leu Ala  His Phe Lys 
    1205                 1210                 1215             


Asp Leu  Gly Asn Lys Asn Leu  Ile Asn Ile Thr Ser  Gln Ile Asn 
    1220                 1225                 1230             


Glu Val  Arg Lys Met Met Ser  Tyr Asp Arg Lys Leu  Lys Asn Ala 
    1235                 1240                 1245             


Val Ser  Lys Ser Met Ile Asp  Leu Phe Glu Arg Tyr  Asn Leu Ile 
    1250                 1255                 1260             


Leu Ser  Phe Lys Val Gln Ser  His Lys Leu Gln Leu  Lys Asn Leu 
    1265                 1270                 1275             


Lys Ser  Lys Gln Ile Thr His  Leu Asn Asn Lys Gly  Ile Thr Glu 
    1280                 1285                 1290             


Asn Leu  Leu Ser Asp Asp Tyr  Phe Ser Val Ile Lys  Arg Leu Leu 
    1295                 1300                 1305             


Leu Thr  Glu Gln Asn Pro Glu  
    1310                 1315 


<210>  963
<211>  1225
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  963

Met Lys Ile Thr Lys Arg Lys Trp Gly Glu His His Pro Pro Leu Tyr 
1               5                   10                  15      


Phe Tyr Arg Asp Glu Asp Ser Gly Arg Leu Leu Ala Gln Asn Asp Arg 
            20                  25                  30          


Lys Gln Asp Tyr Thr Asp Thr Leu Phe Asn Asp Ile Ala Gln Asp Thr 
        35                  40                  45              


Phe Glu Arg Ser Leu Arg Asn Arg Leu Leu Lys Thr Pro Glu Lys Gly 
    50                  55                  60                  


Asp Lys Arg Phe Tyr Ser Asn Glu Ile Val Lys Leu Val Glu Lys Leu 
65                  70                  75                  80  


Cys Gln Gly Ala Asp Val Ala Glu Ile Met Lys Ser Met Glu Arg Ser 
                85                  90                  95      


Glu Lys Leu Arg Pro Lys Asn Glu Lys Glu Ile Lys Asn Leu Lys Lys 
            100                 105                 110         


Gln Leu Tyr Gly Thr Leu Ser Glu Tyr Gly Lys Arg Tyr Thr Ala Pro 
        115                 120                 125             


Glu Gly Ala Met Thr Leu Asn Asp Ala Leu Phe Tyr Leu Val Glu Gly 
    130                 135                 140                 


Asn Pro Leu Lys Gln Ala Met Ala Lys Ala Glu Leu Gly Lys Ile Arg 
145                 150                 155                 160 


Glu Ala Leu Ile Lys Glu Lys Glu Asn Arg Ile Asn Arg Val Arg Tyr 
                165                 170                 175     


Ser Ile Lys Asn Asn Lys Ile Pro Leu Arg Ile Gln Glu Asp Gly Gly 
            180                 185                 190         


Ile Thr Pro Asn Asn Asp Arg Ala Ala Trp Leu Leu Gly Leu Met Lys 
        195                 200                 205             


Pro Ala Asp Pro Ala Lys Gly Ile Thr Asp Cys Tyr Pro Leu Leu Gly 
    210                 215                 220                 


Glu Leu Glu Glu Val Phe Asp Phe Asp Lys Leu Ser Lys Thr Leu His 
225                 230                 235                 240 


Glu Lys Ile Ser Arg Cys Gln Gly Arg Pro Arg Ser Ile Ala Met Ala 
                245                 250                 255     


Val Asp Glu Ala Leu Lys Gln Tyr Leu Arg Glu Leu Trp Glu Lys Ser 
            260                 265                 270         


Pro Ser Arg Gln Gln Asp Leu Lys Tyr Tyr Phe Gln Ala Val Gln Glu 
        275                 280                 285             


Tyr Phe Lys Asp Asn Phe Pro Ile Arg Thr Lys Arg Met Gly Ala Arg 
    290                 295                 300                 


Leu Arg Gln Glu Leu Leu Lys Asp Lys Thr Ser Leu Ser Arg Leu Leu 
305                 310                 315                 320 


Glu Pro Lys His Met Ala Asn Ala Val Arg Arg Arg Leu Ile Asn Gln 
                325                 330                 335     


Ser Thr Gln Met His Ile Leu Tyr Gly Lys Leu Tyr Ala Tyr Cys Cys 
            340                 345                 350         


Gly Glu Asp Gly Arg Leu Leu Val Asn Ser Glu Thr Leu Gln Arg Ile 
        355                 360                 365             


Gln Val His Glu Ala Val Lys Lys Gln Ala Met Thr Ala Val Leu Trp 
    370                 375                 380                 


Ser Ile Ser Arg Leu Arg Tyr Phe Tyr Gln Phe Glu Asp Gly Asp Ile 
385                 390                 395                 400 


Leu Ser Asn Lys Asn Pro Ile Lys Asp Phe Arg Asp Lys Phe Leu Arg 
                405                 410                 415     


Asp Thr Asn Lys Tyr Thr His Glu Asp Val Glu Ala Cys Lys Glu Lys 
            420                 425                 430         


Leu Gln Asp Phe Phe Pro Leu Lys Glu Leu Gln Glu Lys Ile Lys Glu 
        435                 440                 445             


Asp Ala Lys Gly Leu Gln Glu Thr Asp Asn Lys Gln Ala Asp Thr Thr 
    450                 455                 460                 


Asp Phe Lys Ala Ile Gly His Ile Val Arg Asp Asp Arg Lys Leu Cys 
465                 470                 475                 480 


Asn Gln Leu Leu Ala Glu Cys Val Ser Cys Ile Gly Glu Leu Arg His 
                485                 490                 495     


His Ile Phe His Tyr Lys Asn Val Thr Leu Ile Gln Ala Leu Lys Arg 
            500                 505                 510         


Ile Ala Asp Lys Val Lys Pro Glu Asp Leu Ser Val Leu Arg Ala Ile 
        515                 520                 525             


Tyr Leu Leu Asp Arg Arg Asn Leu Lys Lys Ala Phe Ala Lys Arg Ile 
    530                 535                 540                 


Ser Ser Met Asn Leu Pro Leu Tyr Tyr Arg Glu Asp Leu Leu Ser Arg 
545                 550                 555                 560 


Ile Phe Lys Lys Glu Gly Thr Ala Phe Phe Leu Tyr Ser Ala Lys Ile 
                565                 570                 575     


Gln Met Thr Pro Ser Phe Gln Arg Val Tyr Glu Arg Gly Lys Asn Leu 
            580                 585                 590         


Arg Arg Glu Phe Glu Cys Glu Arg Met Lys Ala Glu Ala Ser Asn Gly 
        595                 600                 605             


Gln Asn Gly Gln Asp Gly Asp Arg Leu Lys Trp Phe Arg Gln Leu Ala 
    610                 615                 620                 


Ala Gly Asp Ser Ala Asp Thr His Phe Asn Trp Ala Val Glu Ala Tyr 
625                 630                 635                 640 


Ala Glu Ser Ala Ala Asp Val Glu Asn Asn Val Glu Phe Asp Thr Asp 
                645                 650                 655     


Val Asp Ala Gln Arg Ala Leu Arg Asn Leu Leu Leu Leu Ile Tyr Arg 
            660                 665                 670         


His His Phe Leu Pro Glu Val Gln Lys Asp Glu Thr Leu Val Thr Gly 
        675                 680                 685             


Lys Ile His Lys Val Leu Glu Arg Asn Arg Gln Leu Ser Glu Gly Gln 
    690                 695                 700                 


Gly Pro Asn Gln Gly Lys Ala His Gly Tyr Ser Val Ile Glu Glu Leu 
705                 710                 715                 720 


Tyr His Glu Gly Met Pro Leu Ser Asp Leu Met Lys Gln Leu Gln Arg 
                725                 730                 735     


Arg Ile Ser Glu Thr Glu Arg Glu Ser Arg Glu Leu Ala Gln Glu Lys 
            740                 745                 750         


Thr Asp Tyr Ala Gln Arg Phe Ile Leu Asp Ile Phe Ala Glu Ala Phe 
        755                 760                 765             


Asn Asp Phe Leu Glu Ala His Tyr Gly Glu Glu Tyr Leu Glu Ile Met 
    770                 775                 780                 


Ser Pro Arg Lys Asp Ala Glu Ala Ala Lys Lys Trp Val Lys Glu Ser 
785                 790                 795                 800 


Lys Thr Val Asp Leu Lys Thr Ser Ile Asp Glu Lys Glu Pro Glu Gly 
                805                 810                 815     


His Leu Leu Val Leu Tyr Pro Val Leu Arg Leu Leu Asp Glu Arg Glu 
            820                 825                 830         


Leu Gly Glu Leu Gln Gln Gln Met Ile Arg Tyr Arg Thr Ser Leu Ala 
        835                 840                 845             


Ser Trp Gln Gly Glu Ser Asn Phe Ser Glu Glu Ile Arg Ile Ala Gly 
    850                 855                 860                 


Gln Ile Glu Glu Leu Thr Glu Leu Val Lys Leu Thr Glu Pro Glu Pro 
865                 870                 875                 880 


Gln Phe Ala Glu Glu Val Trp Gly Lys Arg Ala Lys Glu Ala Phe Glu 
                885                 890                 895     


Asp Phe Ile Glu Gly Asn Met Lys Asn Tyr Glu Ala Phe Tyr Leu Gln 
            900                 905                 910         


Ser Asp Asn Asn Thr Pro Val Tyr Arg Arg Asn Met Ser Arg Leu Leu 
        915                 920                 925             


Arg Ser Gly Leu Met Gly Val Tyr Gln Lys Val Leu Ala Ser His Lys 
    930                 935                 940                 


Gln Ala Leu Lys Arg Asp Tyr Leu Leu Trp Ser Glu Lys His Trp Asn 
945                 950                 955                 960 


Val Lys Asp Glu Asn Gly Ala Asp Ile Ser Ser Ala Glu Gln Ala Gln 
                965                 970                 975     


Cys Leu Leu Gln Arg Leu His Arg Lys Tyr Ala Glu Ser Pro Ser Arg 
            980                 985                 990         


Phe Thr Glu Glu Asp Cys Lys Leu  Tyr Glu Lys Val Leu  Arg Arg Leu 
        995                 1000                 1005             


Glu Asp  Tyr Asn Gln Ala Val  Lys Asn Leu Ser Phe  Ser Ser Leu 
    1010                 1015                 1020             


Tyr Glu  Ile Cys Val Leu Asn  Leu Glu Ile Leu Ser  Arg Trp Val 
    1025                 1030                 1035             


Gly Phe  Val Gln Asp Trp Glu  Arg Asp Met Tyr Phe  Leu Leu Leu 
    1040                 1045                 1050             


Ala Trp  Val Arg Gln Gly Lys  Leu Asp Gly Ile Lys  Glu Glu Asp 
    1055                 1060                 1065             


Val Arg  Asp Ile Phe Ser Glu  Gly Asn Ile Ile Arg  Asn Leu Val 
    1070                 1075                 1080             


Asp Thr  Leu Lys Gly Glu Asn  Met Asn Ala Phe Glu  Ser Val Tyr 
    1085                 1090                 1095             


Phe Pro  Glu Asn Lys Gly Ser  Lys Tyr Leu Gly Val  Arg Asn Asp 
    1100                 1105                 1110             


Val Ala  His Leu Asp Leu Met  Arg Lys Asn Gly Trp  Arg Leu Glu 
    1115                 1120                 1125             


Ala Gly  Lys Thr Cys Ser Val  Met Glu Asp Tyr Ile  Asn Arg Leu 
    1130                 1135                 1140             


Arg Phe  Leu Leu Ser Tyr Asp  Gln Lys Arg Met Asn  Ala Val Thr 
    1145                 1150                 1155             


Lys Thr  Leu Gln Gln Ile Phe  Asp Arg His Lys Val  Lys Ile Arg 
    1160                 1165                 1170             


Phe Thr  Val Glu Lys Gly Gly  Met Leu Lys Ile Glu  Asp Val Thr 
    1175                 1180                 1185             


Ala Asp  Lys Ile Ala His Leu  Lys Gly Ser Arg Leu  Ser Gly Ile 
    1190                 1195                 1200             


Glu Ile  Leu Ser His Gly Glu  Arg Phe Ile Asp Thr  Leu Lys Ala 
    1205                 1210                 1215             


Leu Met  Val Tyr Pro Arg Gly  
    1220                 1225 


<210>  964
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  964

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  965
<211>  1208
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  965

Met Leu Ile Val Lys Pro Tyr Gly Trp Ser Lys Ala Gly Arg Gly Glu 
1               5                   10                  15      


Asp Gly Thr Leu Arg Arg Gln Leu Arg Leu Arg Pro Asp Asn Ala Gly 
            20                  25                  30          


Pro Leu Ala Phe Pro Glu Phe Ala Glu Thr His Pro Glu Leu Ile Val 
        35                  40                  45              


Ala Gln Trp Ile Ser Ala Ile Asp Lys Ile Ala Ala Lys Pro Arg Gly 
    50                  55                  60                  


Gln Ala Lys Pro Thr Pro Glu Gln Arg Arg Leu Arg Asn Ile Leu Gly 
65                  70                  75                  80  


Asp Ala Ala Trp Glu Leu Leu Ala Arg Lys His Leu Pro Glu Asp Arg 
                85                  90                  95      


Leu Glu Glu Leu Gly Lys Val Trp Arg Arg Lys Leu His Pro Tyr Gly 
            100                 105                 110         


Gly Glu Glu Asp Asp Arg Ala Ser Gly Arg Glu Lys Gly Arg Trp Tyr 
        115                 120                 125             


Ala Arg Phe Ala Gly Glu Thr Ala Pro Gly Gly Ile Gly Lys Ala Glu 
    130                 135                 140                 


Ala Ala Glu Ile Ala Gly Lys Ile Glu Glu His Leu His Glu Thr Glu 
145                 150                 155                 160 


Tyr Arg Ile Asp Gly Gly Arg Pro Asp Lys Arg Lys Gly Arg Val Ala 
                165                 170                 175     


Thr Arg Ala Ala Ser Ile Ala Gly Asn Val Val Thr Ala Val Ser Glu 
            180                 185                 190         


Leu Gln Gln Ala Gly Trp Thr Glu Asp Asp Leu Glu Arg Tyr Arg Ala 
        195                 200                 205             


Ala Gly Asp Val Ala Thr Ala Ile Lys Ser Ala Ala Glu Asp Leu Glu 
    210                 215                 220                 


Ser Lys Asn Arg Arg Val Gly Pro Arg Ala Ala Ala Glu Ala Leu Tyr 
225                 230                 235                 240 


Ala His Tyr Gly Thr Leu Phe Ala Asp Glu Asp Gly Thr Ala Leu Ala 
                245                 250                 255     


Val Ala Lys Ala Arg Glu Arg Glu Pro Gly Leu Phe Ala Leu His Met 
            260                 265                 270         


Ala Val Arg Glu Thr Tyr Thr Arg Met Leu Lys Asn His Gly Lys Asp 
        275                 280                 285             


Arg Gln Glu His Gly Ala Arg Arg Arg Lys Val Ser Ala Leu Leu Pro 
    290                 295                 300                 


Gly Asp Met Glu Ala Leu Phe Arg Leu Ala Gly Ala Met Gly Arg Asn 
305                 310                 315                 320 


Arg Asp Leu Asn Ala Leu Val Arg Leu Gly Lys Leu Ile His Tyr Glu 
                325                 330                 335     


Ala Ala Pro Ala Pro Asp Ala Glu Ser Ala Thr Gly Asp Glu Pro Val 
            340                 345                 350         


Tyr Ala Val Asp Arg Trp Pro Gly Asp Glu Ala Ile Arg Arg Ser Arg 
        355                 360                 365             


Tyr Arg Thr Ser Ala Gly Gln Ala Glu Ile Lys Arg Asn Glu Ala Phe 
    370                 375                 380                 


Val Arg Ile Trp Arg Gly Ala Gly Ala Leu Ala Gln Arg Thr Leu Thr 
385                 390                 395                 400 


Asp Trp Ala Asp Pro Asp Gly Asp Ile Asp Arg Asp Ile Leu Gly Gly 
                405                 410                 415     


Pro Glu Ile Lys Lys Ala Cys Gly Ala Glu Phe Asn Asp Gly Ala Tyr 
            420                 425                 430         


Arg Ala Lys Leu Pro Ile Leu Phe Gly Ser Arg Ala Glu Leu Phe Asp 
        435                 440                 445             


Asp Ala Glu Gly Pro Gly Ile Leu Arg Leu Ala Leu Glu Gly Trp Thr 
    450                 455                 460                 


Gly Leu Arg Asn Gly Ser Phe His Phe Lys Gly Arg Ala Gly Phe Ala 
465                 470                 475                 480 


Arg Ala Leu Arg Thr Gly Leu Ala Gly Gly Glu Pro Ser Glu Ala Val 
                485                 490                 495     


Ala Glu Leu Val Arg Met Asp Ala Ala Glu Arg Arg Ala Arg Leu Leu 
            500                 505                 510         


Ala Thr Leu Arg Ala Ala His Val Glu Tyr Cys Tyr Ala Gln Glu Gln 
        515                 520                 525             


Leu Gly Ala Leu Phe Asp Ala Leu Ala Asn Gly Ala Pro Ala Val Ser 
    530                 535                 540                 


Pro Leu Pro Arg Phe Arg Arg Val Leu Ala Arg Ala Glu Asn Ala Trp 
545                 550                 555                 560 


Arg Arg Gly Lys Phe Arg Leu Arg Leu Pro Gly Pro Glu Asn Arg Arg 
                565                 570                 575     


Asp Met Glu Ala Ser Pro Gly Arg Leu Ala Arg Tyr Ile Val Leu Lys 
            580                 585                 590         


Thr Leu Tyr Glu Arg Ala Phe Pro Arg Trp Leu Glu Ala Arg Glu Ala 
        595                 600                 605             


Glu Thr Leu Asn Gly Trp Ile Asp Arg Ala Ala Asp Arg Ala Thr Val 
    610                 615                 620                 


Ala Ala Arg His Ile Asn Lys Asp Glu Asp Ala Ala Ala Arg Met Ala 
625                 630                 635                 640 


Gly Leu Val Arg Leu Ala Asp Gly Glu Gly Ile Ala Asp Phe Thr Asp 
                645                 650                 655     


Arg Leu Ala Ala Gln Thr Ala Ser Glu Tyr Arg Val Gln Arg Gly Tyr 
            660                 665                 670         


Asp Ser Asp Pro Ala Val Ala Arg Lys Gln Ala Lys His Ile Glu Asp 
        675                 680                 685             


Leu Arg Cys Asp Val Met Gly Gln Ala Phe Glu Ala Tyr Leu Ala Asp 
    690                 695                 700                 


Glu Ala Arg Lys Leu Ala Trp Thr Met Asn Asp Pro Pro Gly Gly Pro 
705                 710                 715                 720 


Leu Pro Asp Glu Lys Lys Ala Ser Leu Glu Thr Ala Ala Pro Pro Ala 
                725                 730                 735     


Glu Asp Ala Gly Ala Glu Ala Glu Glu Asp Trp Leu Ala Arg Leu Tyr 
            740                 745                 750         


Phe Leu Leu His Met Leu Pro Val Glu Ala Val Gly Gly Leu Arg His 
        755                 760                 765             


Gln Leu His Lys Trp Ser Val Leu Glu Arg Ala Pro Asp Ala Asp Val 
    770                 775                 780                 


Gly Ala Val Glu Arg Ile Leu Gly Leu Tyr Leu Asp Met His Asp Ala 
785                 790                 795                 800 


Lys Phe Glu Gly Gly Lys Gly Val Val Gly Ala Glu Ala Leu Thr Asp 
                805                 810                 815     


Leu Phe Thr Ser Pro Ala Gln Phe Arg Arg Val Cys Pro Glu Asp Gly 
            820                 825                 830         


Ala Gly Asp Asp Gly His Val Pro Trp Arg Gly Leu Arg Glu Met Leu 
        835                 840                 845             


Arg Phe Gly Gly Gly Glu Pro Arg Leu Met Trp Ala Phe Arg Glu Trp 
    850                 855                 860                 


Pro Ile Gly Ala Gly Met Val Asp Gly Leu Glu Ala Leu Glu Ala Thr 
865                 870                 875                 880 


Val Ala Glu Ala His Lys Gln Arg Glu Asp Leu His Ala Lys Trp Ala 
                885                 890                 895     


Gly Lys Lys Gly Phe Ser Arg Lys Asp Lys Asp Glu Tyr Arg Ala Ala 
            900                 905                 910         


Leu Glu Thr Val Val Val His Arg His Leu Ala Ala His Val Gln Leu 
        915                 920                 925             


Val Asn His Ala Arg Leu His Arg Leu Ala Met Ala Val Leu Ala Arg 
    930                 935                 940                 


Leu Ala Asp Tyr Ala Gly Leu Trp Glu Arg Asp Leu Tyr Phe Thr Thr 
945                 950                 955                 960 


Leu Ala Leu Ile Arg Leu Glu Asn Gly Lys Pro Glu Asp Val Phe Arg 
                965                 970                 975     


Ser Ala Gly Phe Lys Arg Leu Arg Glu Gly Arg Ile Val Asp Ala Leu 
            980                 985                 990         


Lys Glu Leu Lys Lys Asn Ala Asp  Gly Ser Glu Ser Ala  Val Glu Thr 
        995                 1000                 1005             


Ala Leu  Gln Arg Leu Phe Gly  Lys Gly Phe Leu Lys  Gly Gly Gly 
    1010                 1015                 1020             


Thr Val  Ser Val Arg Arg Asp  Leu Leu His Phe Asn  Met Leu Gln 
    1025                 1030                 1035             


Arg Lys  Ala Asn Glu Pro Phe  Asn Leu Thr Thr Ala  Val Asn Asp 
    1040                 1045                 1050             


Thr Arg  Arg Leu Met Ala Tyr  Asp Arg Lys Leu Lys  Asn Ala Val 
    1055                 1060                 1065             


Ser Arg  Ser Ile Ile Glu Leu  Leu Ala Arg Glu Gly  Leu Asp Leu 
    1070                 1075                 1080             


Ala Trp  Glu Met Lys Asp His  Lys Leu Ala Gly Ala  Ala Leu Glu 
    1085                 1090                 1095             


Ser Arg  Gln Ala Val His Leu  Gly Gly Ala Lys Val  Gly Gly Gly 
    1100                 1105                 1110             


Pro Ile  Thr Glu Asp Leu His  Gly Pro Glu Phe Thr  Ala Met Ala 
    1115                 1120                 1125             


Ala Ala  Leu Phe Gly Gly Glu  Ala Arg Ala Ala Thr  Asp Ala Ala 
    1130                 1135                 1140             


Glu Ala  Ala Thr Gly Arg Pro  Asp Arg Arg Glu Arg  Lys Ser Gly 
    1145                 1150                 1155             


Gly Ala  Ser Pro Arg Pro Ala  Arg Pro Ala Lys Thr  Leu Pro Ala 
    1160                 1165                 1170             


Pro Thr  Pro Arg Leu Leu Pro  Ala Ala Gly Glu Arg  Val Glu Gly 
    1175                 1180                 1185             


Val Leu  Val Glu Glu Lys Thr  Arg Lys Gly Gly Trp  Lys Ala Ala 
    1190                 1195                 1200             


Val Glu  Ile Gly Gly 
    1205             


<210>  966
<211>  1165
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  966

Met Gly Ser Gly Lys Tyr Arg Ile Thr Lys Ile Ala Arg Lys Trp Asp 
1               5                   10                  15      


Lys Asn Glu Asn Trp Glu Lys Ile Ile Leu Lys Arg Ile Val Asp Asn 
            20                  25                  30          


Lys Lys Ile Lys Tyr Val Asn Glu Asn Asn Asn Lys Asp Val Asp Ile 
        35                  40                  45              


Thr Asp Thr Tyr Tyr Ser Ile Leu Ser Lys Asn Asn Ser Lys Phe Leu 
    50                  55                  60                  


Gly Ser Glu Glu Gln Phe Ile Phe Lys Val Asn Lys Met Lys Arg Asn 
65                  70                  75                  80  


Ile Lys Asn Asp Cys Val Ile Ile Lys Asp Tyr Thr Glu Glu Glu Phe 
                85                  90                  95      


Glu Lys Phe Asp Lys Lys Ile Phe Phe Ser Arg Lys Ile Lys Val Asn 
            100                 105                 110         


Asn Glu Asp Arg Glu Lys Ile Cys Arg Asn Phe Tyr Glu Asp Glu Arg 
        115                 120                 125             


Glu Ile Met Lys Lys Arg Leu Glu Glu Ala Lys Asn Phe Asn Asn Ile 
    130                 135                 140                 


Ile Phe Asn Ile Cys Asn Lys Ile Phe Lys Leu Glu Tyr Ile Asp Tyr 
145                 150                 155                 160 


Thr Asp Glu Lys Val Tyr Glu Ile Phe Gln Lys Glu Ile Lys Phe Glu 
                165                 170                 175     


Asp Ile Lys Asn Leu Lys Glu Ala Phe Lys Gln Gln Glu Asn Gly Leu 
            180                 185                 190         


Glu Thr Asp Lys Leu Leu Thr Ile Ser Phe Asn Lys Lys Arg Ser Asn 
        195                 200                 205             


Val Leu Leu Glu Phe Ile Gln Gln Ile Val Lys Gln Asn Phe Glu Asn 
    210                 215                 220                 


Glu Lys Glu Leu Glu Asn Trp Phe Ser His Asp Gly Glu Lys Tyr Cys 
225                 230                 235                 240 


Lys Glu Ile Phe Lys Ile Tyr Ser Asn Met Ser Gln Lys Glu Lys Tyr 
                245                 250                 255     


Ser Lys Leu Leu Gly His Asn Asp Lys Ser Ile Ala Ser Asn Ser Glu 
            260                 265                 270         


Lys Arg Glu Thr Leu Gln Arg Arg Leu Lys Leu Gly Asp Tyr Ser Lys 
        275                 280                 285             


Tyr Asp Leu Lys Lys Tyr Tyr Gln Lys Asp Tyr Lys Glu Glu Ala Ile 
    290                 295                 300                 


Asn Glu Leu Glu Asp Lys Ser Lys Glu Glu Leu Glu Lys Glu Val Glu 
305                 310                 315                 320 


Glu Ile Ile Lys Lys Asn Tyr Lys Ile Asp Lys Leu Cys Asp Glu Ile 
                325                 330                 335     


Ser Asn Leu Glu Phe Ser Phe Val Asp Ser Lys Lys Glu Asn Lys Asp 
            340                 345                 350         


Lys Met Ser Glu Ile Ile Val Lys Ile Lys Glu His Tyr Lys Asn Asn 
        355                 360                 365             


Val Asn Val Glu Glu Glu Leu Glu Asn Lys Glu Lys Tyr Ile Leu Ser 
    370                 375                 380                 


Met Ile His Asn Tyr Ile Lys Gly Arg Tyr Arg Lys Cys Leu Glu Leu 
385                 390                 395                 400 


Gln Gln Lys Glu Asn Val Asp Phe Glu Asn Leu Gly Lys Arg Ile Lys 
                405                 410                 415     


Glu Ile Phe Asp Ser Asn Lys Val Thr Glu Lys Leu Lys Lys Ser Ile 
            420                 425                 430         


Leu Asn Lys Val Asn Asn Tyr Lys Ile Phe Glu Thr Lys Phe Gln Asn 
        435                 440                 445             


Pro Asn Ile Glu Ser Ser Asp Asp Leu Glu Ile Leu Lys Ala Glu Glu 
    450                 455                 460                 


Thr Phe Leu Asn Lys Leu Ser Thr Ala Val Ser Lys Val Gly Tyr Ile 
465                 470                 475                 480 


Leu Asn Ile Leu Leu Glu Ile His Phe Arg Asn Asp Ile Leu Gln Asp 
                485                 490                 495     


Tyr Asn Gln Val Glu Lys Leu Trp Lys Ser Asp Ser Phe Gln Lys Ile 
            500                 505                 510         


Cys Ala Ile Tyr Pro Glu Ile Asn Asn Asp Glu Lys Leu Leu Lys Gly 
        515                 520                 525             


Met Ile Tyr Phe Ile Gln Gly Leu Arg Gln Gln Val Leu His Pro Lys 
    530                 535                 540                 


Ile Leu Trp Glu Lys Gln Asn Ile Tyr Asn Ala Glu Asn Ile Lys Glu 
545                 550                 555                 560 


Lys Glu Lys Ile Val Ser Val Arg Leu Gln Asn Glu Gly Glu Ala Tyr 
                565                 570                 575     


Asn Lys Lys Gly Ile Gln Asn Tyr Phe Glu Asn Val Leu Lys Lys Ile 
            580                 585                 590         


Pro Asp Tyr Phe Ile Glu Lys Tyr Glu Ser Ser Asn Val Phe Asn Ile 
        595                 600                 605             


Tyr Arg Asn Phe Val Asp Lys Ile Met Glu Val Val Lys Asn Phe Asn 
    610                 615                 620                 


Phe Lys Glu Asn Asn Thr Ile Asp Tyr Leu Phe Pro Lys Phe His Lys 
625                 630                 635                 640 


Ile Tyr Lys Arg Met Cys Lys Leu Glu Asn Ile Asp Asp Arg Gln Asn 
                645                 650                 655     


Gly Ala Arg Lys Tyr Leu Leu Gln Ile Ile Tyr Tyr Tyr Tyr Phe Gln 
            660                 665                 670         


Tyr Glu Ile Glu Asn Asp Lys Asn Asn Ile Ser Lys Tyr Leu Asn Leu 
        675                 680                 685             


Tyr Arg Asn Lys Ile Lys Val Lys Lys Ile Ser Tyr Ser Tyr Ile Thr 
    690                 695                 700                 


Asp Asn Lys Ala Val Asn Asn Lys Asn Ile Glu Ile Leu Tyr Arg Asn 
705                 710                 715                 720 


Ile Gln Arg Glu Gly Met Leu Asn Asn Lys Leu Ser Gln Met Asn Lys 
                725                 730                 735     


Glu Trp Ile Glu Phe Ile Val Val Gln Phe Ser Glu Phe Leu Thr Asn 
            740                 745                 750         


Lys Lys Leu Asn Trp Ile Leu Asp Asn Leu Ser Gly Tyr Lys Lys Lys 
        755                 760                 765             


Glu Lys Leu Asp Glu Asn Asp Lys Asn Arg Leu Leu Lys Ile Leu Lys 
    770                 775                 780                 


Gln Lys Met Asn Lys Lys Ile Ile Tyr Ser Asn Asp Ser Tyr Ala Phe 
785                 790                 795                 800 


Ile Ser Leu Ala Gln Phe Leu Asp Leu Lys Glu Ile Ser Asn Leu Ile 
                805                 810                 815     


His Asp Ile Lys Lys Phe Ile Gln Phe Arg Glu Lys Asn Val Ser Lys 
            820                 825                 830         


Tyr Lys Pro Glu Lys Asn Lys Leu Tyr Ile Lys Glu Leu Arg Lys Val 
        835                 840                 845             


Leu Tyr Ile Leu Lys Val Met Leu Glu His Lys Glu Arg Val Ile Gln 
    850                 855                 860                 


Lys His Tyr Leu Glu Ser Tyr Asp Glu Asn Ile Ser Ile Ile Tyr Gly 
865                 870                 875                 880 


Lys Asp Ile Glu Arg Lys Asp Ile Lys Asp Ile Lys Ile Lys Ile Lys 
                885                 890                 895     


Asn Glu Asn Gln Glu Ile Ile Asn Gln Pro Leu Tyr Lys Ser Gly Asn 
            900                 905                 910         


Asp Glu Asn Ser Ser Trp Ile Val Leu Tyr Gly Ile Glu Gln Ala Lys 
        915                 920                 925             


Arg Asn Gly Thr Phe Lys Phe Phe Glu Gly Phe Phe Asn Leu Asn Asp 
    930                 935                 940                 


Asp Ile Lys Leu Cys Lys Glu Asn Ile Glu Lys Tyr Glu Glu Leu Tyr 
945                 950                 955                 960 


Asn Glu Lys Glu Glu Asn Gln Arg Lys Val Asp Glu Tyr Ile Ser Ser 
                965                 970                 975     


Glu Glu Asn Asn Asn Ile Asp Glu Ile Lys Glu Ile Asn Asn Asn Lys 
            980                 985                 990         


Gln Leu Phe Tyr Tyr Tyr Lys Asn  Met Ile Tyr Gly Asp  Gly Leu Lys 
        995                 1000                 1005             


Lys Gly  Tyr Asp Phe Ile Asn  Asp Ile Tyr Ser His  Tyr Leu Ser 
    1010                 1015                 1020             


Trp Ala  Tyr Arg Val Glu Arg  Asp Cys Lys Ile Tyr  Lys Ile Lys 
    1025                 1030                 1035             


Glu Tyr  Glu Asn Lys Lys Asn  Phe Asn Glu Tyr Lys  Phe Lys Glu 
    1040                 1045                 1050             


Tyr Lys  Ser Ile Lys Asn Phe  Arg Asn Glu Ile Ala  His Phe Asn 
    1055                 1060                 1065             


Tyr Phe  Gln Lys Thr Asn Lys  Ser Leu Leu Glu Leu  Leu Asn Asp 
    1070                 1075                 1080             


Phe Tyr  Asp Ile Phe Asp Tyr  Asn Leu Lys Tyr Gln  Arg Asp Val 
    1085                 1090                 1095             


Gln Asn  Val Ile Asn Asn Ile  Phe Glu Lys Tyr Gln  Ile Val Arg 
    1100                 1105                 1110             


Lys Asp  Gly Gly Pro Val Val  Phe Tyr Cys Lys Thr  Asp Lys Lys 
    1115                 1120                 1125             


Leu Lys  Leu Ser Glu Asn Leu  Val Pro Lys Lys His  Ser Lys Tyr 
    1130                 1135                 1140             


Pro Glu  Ile Lys Leu Ile His  Glu Lys Tyr Val Met  Phe Phe Arg 
    1145                 1150                 1155             


Lys Leu  Phe Glu Tyr Lys Lys  
    1160                 1165 


<210>  967
<211>  1298
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  967

Met Thr Arg Ala Ala Leu Asp Gln Glu Val Ile Met Arg Ile Gly Lys 
1               5                   10                  15      


Val Gln Gly Arg Thr Phe Thr Gly Phe Asp Asn Ala Arg Gly Lys Thr 
            20                  25                  30          


Leu Arg Arg Arg Leu Leu Thr Arg Pro Asp Asn Glu Ala Arg Ser Leu 
        35                  40                  45              


Ser Glu His Leu Ala His Asp Pro Lys Ala Leu Ile Gly Gln Ala Ile 
    50                  55                  60                  


Ser Arg Ile Asp Thr Ile Tyr Gln Lys Pro Lys Thr Gly Lys Pro Thr 
65                  70                  75                  80  


Pro Glu Gln Phe Gly His Arg Asp Thr Leu Gly Trp Ala Tyr Trp Lys 
                85                  90                  95      


Leu Leu Val Ala Ser Tyr Pro Glu Val Glu Gly His Arg Asp Leu Phe 
            100                 105                 110         


Val Arg Arg Leu His Pro Tyr Gly Asp Thr Pro Pro Lys Ser His Gly 
        115                 120                 125             


Gln Lys Glu Gly Glu His Gln Lys Gly Gly Lys Pro Gln Leu Glu Gly 
    130                 135                 140                 


Arg Trp His Gly Val Met Ala Gln His Gly Lys Asn Pro Asp Gln Ile 
145                 150                 155                 160 


Ala Ala Arg Leu Phe Asp His Leu His Asn Ser Glu Leu Arg Phe Gly 
                165                 170                 175     


Gly Thr Ala Ser Gly Glu Pro Arg Thr Arg Pro Gly Lys Glu Ala Thr 
            180                 185                 190         


Pro Thr Gly Leu Ile Gly Ala Arg Ala Lys Thr Ile Glu His Ser Val 
        195                 200                 205             


Leu Pro Arg Asp Ala Lys Arg Phe Val Ala Glu Trp Arg Gly Glu Asp 
    210                 215                 220                 


Gln Glu Arg Tyr Ala Gly Ala Arg Asp Ile Ala Ala Ala Ile Ser Ala 
225                 230                 235                 240 


Gly Leu Asn Asp Lys Asp Gln Lys Ser Gly Ser Gly Arg Lys Ser Ala 
                245                 250                 255     


Val Ile Gly Lys Leu Leu Ser Asp His Leu Glu Thr Leu Thr Gly Asn 
            260                 265                 270         


Arg Lys Cys Arg Phe Asp Pro Lys Ser Thr Ala Glu Thr Leu Glu Leu 
        275                 280                 285             


Arg Asp Gly Glu Ser Val Asp Asp Arg Arg Arg Ile Leu Glu Leu His 
    290                 295                 300                 


Ala Glu Val Lys Ala Thr Tyr Lys Arg Met Ala Ala Trp Lys Pro Ala 
305                 310                 315                 320 


Lys Leu Pro Arg Asn Ser Asp Glu Leu Phe Arg Leu Val Arg Gln Gln 
                325                 330                 335     


Ala Asp Asn Arg Ile Leu Asn His Leu Val Arg Val Gly Arg Ile Ser 
            340                 345                 350         


Val Tyr Ser Glu Gln Ser Asp Ala Leu Ser Glu Ser Gln Phe Trp Thr 
        355                 360                 365             


Ser Gly Gly Gln Thr Gln Ile Lys Glu Ser Glu Val Phe Ala Arg Leu 
    370                 375                 380                 


Trp Ile Gly Ala Ile Ser Arg Ala Ser Tyr Ser Met Lys Ala Trp Leu 
385                 390                 395                 400 


Glu Pro Glu Gly Thr Val Phe Asn Pro Ser Ile Asn Asp Phe Asp Val 
                405                 410                 415     


Thr Ser Ser His Asn Thr Asn Arg Ile Leu Glu Asp Ser Gly Arg Leu 
            420                 425                 430         


Ser Asn Ala Met Ala Arg Arg Ala Ile Tyr Phe Gly Glu Thr Pro Glu 
        435                 440                 445             


Phe Asp Ala Leu Gly Glu Glu Asp Gln Arg Val Leu Val Lys Lys Cys 
    450                 455                 460                 


Leu Asp Ala Leu Ser Ala Cys Arg Asn Arg Thr Phe His His Gly Gln 
465                 470                 475                 480 


Arg Ala Lys Phe Leu Lys Glu Val Arg Lys Gly Leu Lys Glu Lys Glu 
                485                 490                 495     


Ala Asp Ser Ala Gly Pro Ala Ala Trp Glu Gly Ile Arg Glu Val Ile 
            500                 505                 510         


Gln Ala Asp Ala Arg Asn Leu Gly Ala Arg Leu Leu Gln Asp Leu Thr 
        515                 520                 525             


Gly Ala Lys Val His Ser Phe Ala Thr Asp Pro Glu Phe Arg His Leu 
    530                 535                 540                 


Tyr Glu Ser Val Ala Ala Thr Leu Thr Ala Gly Gly Glu Leu Glu Ala 
545                 550                 555                 560 


Ala Leu Pro Arg Leu Lys Asn Val Leu Lys Arg Ala Glu Gly Val Arg 
                565                 570                 575     


Cys Tyr Leu Asp Thr Pro Ser Gln Arg Arg Glu Gly Asp Glu Ser Leu 
            580                 585                 590         


Ile Ala Arg Leu Pro Val Ala Pro Val Pro Arg Glu Leu Asp Asp Ala 
        595                 600                 605             


Ala Thr Lys Ala Arg His Ser Ala Leu Leu Arg Leu Tyr Asp Gly Pro 
    610                 615                 620                 


Phe Arg Pro Trp Ala Thr Glu Leu Arg Gly Glu Arg Leu Ser Asp Tyr 
625                 630                 635                 640 


Ala Ala Arg Ala Lys Arg Leu Ala Thr Arg Leu Ala Lys Ser Thr Asn 
                645                 650                 655     


Thr Ala Ser Pro Tyr Pro Asp Ser Val Glu Gly Arg Ser Val Arg Leu 
            660                 665                 670         


Arg Asp Pro Ile Thr Ala Asp Thr Ala Pro Glu Thr Leu Lys Thr Tyr 
        675                 680                 685             


Leu Ser Ala Leu Thr Ala Glu Thr Ala Thr Glu Phe Arg Val Gln Lys 
    690                 695                 700                 


Gly Tyr Glu Ser Asp Gly Glu Lys Ala Lys Glu Gln Ala Glu Phe Ile 
705                 710                 715                 720 


Glu Asp Phe Arg Arg Asp Met Ile Ala Leu Ala Phe Gln Asp Phe Ile 
                725                 730                 735     


Arg Asp His Gly Phe Ala Trp Leu Leu Asp Ile Ala Ser Lys Ala Glu 
            740                 745                 750         


Pro Ser Asn Asp Ala Pro Asn Leu Pro Asp Pro Val Asp Thr Gly Lys 
        755                 760                 765             


Asp Thr Val Phe Glu Asp Trp Gln Ala Leu Leu Tyr Leu Phe Leu His 
    770                 775                 780                 


Phe Val Pro Ala Asp Asp Val Ser Gln Leu Leu His Gln Leu Arg Lys 
785                 790                 795                 800 


Trp Asp Ala Leu Gln Asp Lys Tyr Glu Leu Ala Glu Pro Gly Glu Thr 
                805                 810                 815     


Leu Gly Gln Thr Lys Ala Asp Thr Arg Lys Ile Val Gly Gln Phe Arg 
            820                 825                 830         


Asp Cys Leu Thr Leu Phe Leu Lys Thr Gly Asp Ala Arg Phe Asp Gly 
        835                 840                 845             


Glu Gly Val Glu Leu Pro Leu Ser Asp Phe Gln Glu Leu Phe Glu Ser 
    850                 855                 860                 


Pro Ala Thr Phe Lys Glu Leu Phe Leu Ala Glu Pro Ala Glu Asn Asp 
865                 870                 875                 880 


Ala Ser Glu Thr Asp Asp Gln Asp Ala Pro Gly Glu Lys His Arg Val 
                885                 890                 895     


Thr Arg Thr Arg Arg Gly Leu Arg Gln Ile Leu Arg Tyr Asn His Met 
            900                 905                 910         


Pro Val Leu Arg Asp Leu Phe Leu Ala His Lys Val Thr Asp Ala Glu 
        915                 920                 925             


Val Asp Gly Leu Gln Ala Leu Glu Val Asp Asp Pro Gln Thr Gly Glu 
    930                 935                 940                 


Ser Gln Ile Gly Ala Ala Gln Arg Ile Arg Thr Glu Ile His His His 
945                 950                 955                 960 


Thr Ser Asn Asp Lys Gln Ile Ser Glu Ala Lys Val Glu Glu Tyr Arg 
                965                 970                 975     


Arg Ala Leu Ser Thr Ile Glu Arg His Arg Phe Leu Val Gly Arg Val 
            980                 985                 990         


Tyr Leu Gly Asp His Ile Arg Val  His Lys Leu Met Met  Asp Val Met 
        995                 1000                 1005             


Gly Arg  Leu Val Asp Phe Ala  Gly Ala Trp Glu Arg  Glu Ala Ala 
    1010                 1015                 1020             


Asp Gly  Asp Arg Lys Gly Phe  Ile Ser Arg Ala Ile  Ala Leu Pro 
    1025                 1030                 1035             


Glu Val  Ala Glu Gly Tyr Ala  Ala Asp Arg Leu Lys  Thr Val Ala 
    1040                 1045                 1050             


Arg Arg  Val Leu Asp Asp Gly  Glu Ala Arg Arg Ile  Arg Asn Asp 
    1055                 1060                 1065             


Leu Gly  His Phe Asn Asp Leu  Ala Pro Thr Ser Gly  Pro Ala Asn 
    1070                 1075                 1080             


Leu Thr  Phe Val Val Asn Arg  Ala Arg Arg Met Met  Arg His Asp 
    1085                 1090                 1095             


Arg Lys  Arg Lys Asn Ala Val  Thr Lys Ser Val Ile  Glu Ile Leu 
    1100                 1105                 1110             


Asn Arg  Gln Gly Leu Gly Ile  Glu Trp Thr Met Arg  Asn His Glu 
    1115                 1120                 1125             


Leu Cys  Glu Ala Lys Leu Trp  Gln Asn Pro Val Lys  His Leu Gly 
    1130                 1135                 1140             


Phe Ala  Thr Leu Glu Gly Arg  Gly Lys Lys Trp Arg  Arg Pro Phe 
    1145                 1150                 1155             


Glu Ala  Arg Tyr Gly Asp Ala  Tyr Met Ala Met Val  Ala Gln Leu 
    1160                 1165                 1170             


Phe Asp  Gly Thr Val Thr Ser  Pro Pro Ala Lys Gly  Pro Pro Gln 
    1175                 1180                 1185             


Ser Gly  Lys Ser Gly Gly Lys  Pro Gly Lys Gly Ala  Glu Gly Gly 
    1190                 1195                 1200             


Ala Lys  Glu Lys Ser Arg Ser  Pro Thr Arg Met Glu  Glu Gly Gly 
    1205                 1210                 1215             


Val Tyr  Glu Gly Arg Val Ala  Lys Ala Lys Ser Asp  Lys Gly Phe 
    1220                 1225                 1230             


Gly Phe  Leu Leu Val Glu Gly  Ala Gln Glu Glu Ile  Phe Leu His 
    1235                 1240                 1245             


Ile Tyr  Gly Ile Ser Gly Asn  Arg Pro Ala Arg Ile  Glu Asn Gly 
    1250                 1255                 1260             


Gln Arg  Tyr Arg Phe Thr Leu  Gly Ile Asp Arg Asp  Arg Glu Arg 
    1265                 1270                 1275             


Arg Lys  Glu Arg Ala Trp Val  Ala Arg Glu Ala Val  Arg Ile Asp 
    1280                 1285                 1290             


Glu Asn  Arg Ser Lys 
    1295             


<210>  968
<211>  1419
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  968

Val Arg Thr Pro Phe Leu Arg Ser Ser Phe Thr Ser Arg Leu Cys Leu 
1               5                   10                  15      


Leu Gly Arg Thr Ala Ser Gly Gln Cys Cys Val Ile Glu Tyr Pro Ile 
            20                  25                  30          


Glu Tyr Pro Cys Val Lys Gly Leu Ala Lys Arg Ser Ala Ile Met Ala 
        35                  40                  45              


Lys His Leu Arg Pro Ile Gly Glu Ser Tyr Thr Asp Phe Leu Asp Glu 
    50                  55                  60                  


Thr Glu Phe Val Arg Leu Gly Arg Gly Leu His Arg Gly His His Gly 
65                  70                  75                  80  


Val Gln Ile Pro Pro Thr Glu Leu Pro Ser Tyr Leu Ala Glu Tyr Arg 
                85                  90                  95      


Lys Ala Leu Met Arg Gln Val Val Ala Val Leu Asp Lys Val Val Gly 
            100                 105                 110         


Lys Arg Arg Arg Leu Ser Gly Met His Pro Glu Ala Tyr Arg Asp Arg 
        115                 120                 125             


Val His Leu Ala Glu Ala Leu Trp Val Arg Leu Val Ala Arg Val Lys 
    130                 135                 140                 


Glu Ile Gly Thr Pro Pro Asp Pro Ser Glu Leu Leu Asp Leu Arg Arg 
145                 150                 155                 160 


Met Trp Asn Ala Lys Ala His Pro Tyr Ala Glu Tyr Asp Val Val Pro 
                165                 170                 175     


Arg Ala Pro Leu Asn Asp Gly Asn Gly Gln Lys Ile Leu Glu Cys Arg 
            180                 185                 190         


Glu Val Asp Asp Pro Lys Ile Glu Arg Ser Asp Phe Glu Gly Arg Trp 
        195                 200                 205             


His Gly Arg Phe Trp Gln Ser Glu Pro Gly Pro Val Asp Tyr Asn Ala 
    210                 215                 220                 


Ile Ala Asp Arg Ile Phe Ala His Leu Phe Asp Gln Glu Ala Val Ile 
225                 230                 235                 240 


Gly Gly Gly Pro Arg Arg Glu Gly Asn Val Thr Val Pro Asp Glu Asp 
                245                 250                 255     


Ile Asn Gly Gln Pro Gly Pro Ala Thr Gly Lys Gly Leu Ile Ile Ala 
            260                 265                 270         


Arg Gly Gln Ser Ile Val Lys Ser Ala Ser Asp Pro Arg Arg Ser Ser 
        275                 280                 285             


Lys Lys Val Gln Arg Thr Trp Asp Lys Ala Val Glu Arg Arg Tyr Phe 
    290                 295                 300                 


Gly Asp Asp Gly Lys Gly Gly Ser Asp Ile Ala Lys Ala Ile Tyr Glu 
305                 310                 315                 320 


Glu Leu Gly Asp Pro Ala Thr Leu Ala Asp Pro Ile Tyr Ala Ser Trp 
                325                 330                 335     


Phe Gly Ser Arg Leu Tyr Asp His Phe Gly Ser Phe Lys Asn Ser Leu 
            340                 345                 350         


Pro Leu Glu Leu Lys Asp Pro Phe Lys Glu Gln Ile Trp Ala Leu His 
        355                 360                 365             


Asn Ser Val Arg Gln Phe Tyr Gln Arg Met Ala Lys Ser Asp Arg Phe 
    370                 375                 380                 


Arg Leu Ala Leu Gln Asn Ala Arg Ser Glu Val Pro Asp Arg Ser Glu 
385                 390                 395                 400 


Leu Leu Ala Leu Leu Pro Lys Asp His Asp His Leu Leu Leu Val Leu 
                405                 410                 415     


Gly Gly Lys Lys Lys Asn Ala Glu Met Ser Glu Leu Ile Arg Leu Gly 
            420                 425                 430         


Lys Leu Phe Val His Ala Ser Asp Val Leu His Asp Phe Asp Ala Asn 
        435                 440                 445             


Asp Ala Ala Ala Leu Asp Ala Phe Lys Arg Arg Met Ser Phe Leu Ala 
    450                 455                 460                 


Thr Ser Ile Gly Gln Ser Glu Ile Lys Gln Thr Glu Thr Phe Ala Arg 
465                 470                 475                 480 


Thr Trp Arg Gly Ala Val Gly Leu Thr Leu Arg Thr Val Lys Gly Leu 
                485                 490                 495     


Ala Asp Pro Arg Gly Ile Ile Gly Thr Pro Asp Asn Arg Asp Leu Gly 
            500                 505                 510         


Thr Ala Gly Pro Met Lys Asp Ala Phe Asn Lys Phe Asp Gln Pro His 
        515                 520                 525             


Phe Gln Gln His Met Thr Ile Ile Phe Gly Asn Lys Glu Leu Gln Ala 
    530                 535                 540                 


Glu Gly Asn Pro Thr Arg Ser Ser Val Phe Thr Ala Asn Gly Asp Lys 
545                 550                 555                 560 


Asp His Gln Ala Glu Leu Leu Trp Gly Phe Leu Cys Val Val Arg Ser 
                565                 570                 575     


Val Arg Asn Arg Thr Asn His Tyr Asn Val Arg Arg Ala Leu Leu Arg 
            580                 585                 590         


Leu Leu Asp Glu Gly Ile Val Ser Pro Met Pro Ser Asp Pro Lys Lys 
        595                 600                 605             


Glu Arg Val Glu Asn Arg Asn Leu Cys Thr Val Ser Pro Thr Ala Leu 
    610                 615                 620                 


Glu Ala Phe Arg Arg Leu Leu Asn Phe Asp Leu Ala Ile Gln Lys Glu 
625                 630                 635                 640 


Ala Val Arg Thr Ala Leu Glu Gln Ala Lys Ala Ser Glu Phe Val Glu 
                645                 650                 655     


Glu Gly Lys Leu Arg Gly Leu Val Ser Glu Leu Ala Gly Thr Glu Asp 
            660                 665                 670         


Met Pro Ala Leu His Ile Pro Arg Phe Ser Ala Val Met Asp Lys Val 
        675                 680                 685             


Arg Arg Leu Ala Asp Asn Arg Asp Val Gly Leu Asp Pro Ile Leu Ser 
    690                 695                 700                 


Thr Leu Gln Arg Ser Leu Pro Pro Thr Asp Lys Gln Ala Glu Ser Asp 
705                 710                 715                 720 


Ala Ala Arg Cys Arg Tyr Arg Leu Leu Leu Glu Leu Tyr Lys Ser Gly 
                725                 730                 735     


Phe Arg Ser Trp Phe Ser Gly Ile Gln Ser Asn Glu Glu Asn Asn Arg 
            740                 745                 750         


Glu Ile Cys His Trp Ala Val Lys Gln Val Gly Arg Ala Lys Asp Ala 
        755                 760                 765             


Arg Lys Ser Glu Tyr Asp Lys Lys Thr Lys Arg His Tyr Arg Ser Pro 
    770                 775                 780                 


Asn Ser Leu Ile Asp Asp Leu Gly Leu Asp Lys Phe Asp Asp Leu Thr 
785                 790                 795                 800 


Asp Leu Leu Glu Ala Leu Ala Ser Gln Ser Thr Arg Glu His Asp Gln 
                805                 810                 815     


Asn Leu Lys Tyr Val Pro Asp Ala Arg Val Gln Ser Gln Met Ser Asn 
            820                 825                 830         


Arg Ile Glu Glu Phe Arg Gln Glu Leu Phe Ala His Ile Phe Thr Lys 
        835                 840                 845             


Tyr Leu Asp Thr His Asp Phe Gly Trp Ile Gly Ala Ile Glu Val Arg 
    850                 855                 860                 


Arg Glu Ala Cys Asp Leu Ala Asp Val Val Ser Ala Phe Glu Val Arg 
865                 870                 875                 880 


Asp Gln Lys Phe Asp Ala Asp Trp His Ser Gln Phe Tyr Ala Trp Leu 
                885                 890                 895     


Tyr Met Val Pro Pro Ile Glu Ala Ser Arg Leu Arg His Gln Met Arg 
            900                 905                 910         


Lys Ser Ala Val Met Asp Asp Lys Trp Ser Thr Thr Leu Glu Leu Thr 
        915                 920                 925             


Ser Gly Asp Arg Lys Thr Arg Asp Asp His Ala Gln Asp Val Leu Ala 
    930                 935                 940                 


Asp Met Asp Arg Leu Phe Ser Leu Tyr Thr Lys Val Gln Ala Ala Gly 
945                 950                 955                 960 


Phe Asn Gly Gln Glu His Glu Ser Ala Leu Gly Ser Lys Ser Leu Phe 
                965                 970                 975     


Tyr Glu Asp Gly Asn Gln Phe Asp Glu Val Tyr Ser Pro Asp Thr Glu 
            980                 985                 990         


Thr His Asn Lys Thr Phe Pro Gly  Thr Arg Arg Gly Leu  Arg Gln Leu 
        995                 1000                 1005             


Val Arg  Tyr Ala His Leu Pro  Ala Leu Glu Gly Val  Phe Lys Lys 
    1010                 1015                 1020             


His Arg  Ile Thr Lys Ala Glu  Val Glu Thr Phe Val  Ala Leu Tyr 
    1025                 1030                 1035             


Asp Glu  Asn Arg Arg Asp Pro  Gly Ser Val Ala His  Met Leu Arg 
    1040                 1045                 1050             


Arg Glu  Lys Leu Arg Thr Glu  Ile Leu Arg Ser Ile  His Asp Gly 
    1055                 1060                 1065             


Pro Lys  Pro Lys Asp Lys Asp  Phe Trp Pro Lys Leu  Glu Ala Lys 
    1070                 1075                 1080             


Cys Leu  Glu Tyr Arg Thr Val  Ala Thr Glu Thr Ala  Ile Tyr Asn 
    1085                 1090                 1095             


Phe Gln  Ala Asn Ala Ala Arg  Leu Asn Asp His Ala  Arg Leu His 
    1100                 1105                 1110             


Gln Ile  Val Met Arg Val Val  Ala Arg Leu Thr Asp  Tyr Ala Leu 
    1115                 1120                 1125             


Ile Trp  Glu Arg Asp Arg Leu  Phe Ala Phe Val Gly  Met Leu Tyr 
    1130                 1135                 1140             


Arg Gln  Thr Gly Gly Thr Gly  Ile Asn Pro Ala Met  Arg His Ala 
    1145                 1150                 1155             


Glu Lys  Thr Asn Ala Pro Pro  Arg Ile Gly Ile Leu  Val Ser Asp 
    1160                 1165                 1170             


Ser Ala  Leu Ala Lys Lys Leu  Asn Ser Asn Ser Ala  Glu Val Phe 
    1175                 1180                 1185             


Ile Pro  Tyr Leu Asp Thr Glu  Thr Gly Phe Asp Ala  Pro Arg Phe 
    1190                 1195                 1200             


Asp Asp  Leu Cys Thr Leu Leu  Ser His Glu His Ala  Lys Glu Phe 
    1205                 1210                 1215             


Arg Phe  His Phe Leu Glu Val  Gly Glu Glu Asn Ser  Lys Asp Glu 
    1220                 1225                 1230             


Ala Arg  Arg Leu Asn Glu Glu  Thr Met Gly His Arg  Lys Arg Pro 
    1235                 1240                 1245             


Ala Phe  Lys Arg Gly Thr Arg  Arg Gln Gly Ile Arg  Asn Asp Leu 
    1250                 1255                 1260             


Ala His  His Asn Val Leu Asp  Leu Ala Gly Gly Ala  Gly Pro Asn 
    1265                 1270                 1275             


Leu Thr  Tyr Val Val Asn Ala  Val Arg Ser Leu Leu  Ser Tyr Asp 
    1280                 1285                 1290             


Arg Lys  Leu Lys Asn Ala Val  Pro Lys Ser Ile Lys  Arg Ile Leu 
    1295                 1300                 1305             


Gly Glu  Glu Gly Leu Ile Ile  Glu Trp Gln Met Asn  Tyr Asp Arg 
    1310                 1315                 1320             


Leu Lys  Lys Pro Thr Val Tyr  Pro Asn Val Glu Thr  His Leu Thr 
    1325                 1330                 1335             


Met Val  Pro Pro Arg His Met  Thr Ala Pro Val Ser  Phe Thr Leu 
    1340                 1345                 1350             


Pro Arg  Ala Ser Val Arg Leu  Ala Ser Met Val Lys  Ala Val Phe 
    1355                 1360                 1365             


Asp Phe  Gly Ser Ser Gly Tyr  Gly Glu Glu Arg Met  Ile Gly Gly 
    1370                 1375                 1380             


Arg Thr  Ala Lys Gln Ala Val  Tyr Pro Asp Asp Phe  Thr Arg Arg 
    1385                 1390                 1395             


Phe Pro  Gln Thr Pro Met Gly  Leu Lys Gln Ala Thr  Arg Leu Val 
    1400                 1405                 1410             


Phe Ala  Ser Glu Asn Ser 
    1415                 


<210>  969
<211>  1282
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  969

Met Gln Ser Pro Glu Ala Leu Ala Pro Ala Ala Arg Gly Ala Trp Asn 
1               5                   10                  15      


Gly Gly Lys Ala Met Arg Ile Val Arg Pro Tyr Gly Glu Ser Arg Ala 
            20                  25                  30          


Gly Ala Gly Ala Glu Gly Pro Arg Arg Arg Val Leu Val Asp Thr Thr 
        35                  40                  45              


Pro Gln Arg Gln Ala His Asp Ile Pro Ala Phe Ala Gly Ser His Asp 
    50                  55                  60                  


Ala Leu Val Leu Ala Gln Trp Ile Ser Leu Leu Asp Arg Ile Ala Thr 
65                  70                  75                  80  


Lys Pro Ser Asp Asn Asn Gly Pro Thr Asp Arg Gln Arg Ala Phe Arg 
                85                  90                  95      


Asp Arg Leu Gly Glu Ala Ala Trp Ala Gln Ile Cys Ala Ser Asp Arg 
            100                 105                 110         


Ile Asp Pro Ala Gly Arg Ala His Leu Glu Thr Leu Trp Arg Phe Lys 
        115                 120                 125             


Thr His Pro Tyr Gly Asn Ala Lys Tyr Arg Pro Arg Lys Thr Lys Asp 
    130                 135                 140                 


Gly Gln Thr Lys Pro Asp Pro Asp Pro Arg Gly Arg Trp Tyr Arg Arg 
145                 150                 155                 160 


Phe Val Gly Asp Val Ala Pro Glu Gln Ala Asp Val Asn Ala Ile Ala 
                165                 170                 175     


Arg Leu Met Asp Arg His Leu His Val Ala Glu Leu Arg Met Asp Pro 
            180                 185                 190         


Asp Arg Pro Asp Lys Cys Lys Gly Val Ile Gln Ala Arg Ala Glu Ser 
        195                 200                 205             


Ile Ala Gly Asn Val Pro Gln Glu Asn Pro Arg Pro Pro Gln Arg Asp 
    210                 215                 220                 


Arg Asp Gln Thr Thr Ala Glu Arg Tyr Phe Ala Ala Asp Asp Val Ala 
225                 230                 235                 240 


Lys Arg Ile Phe Lys Ala Ala Arg Glu Arg Glu Gln Ser Glu Asn Gly 
                245                 250                 255     


Ala Thr Lys Val Pro Val Arg Arg Ser Phe Ala Ala Glu Ile Leu His 
            260                 265                 270         


Ala His Phe Ala Lys Val Phe Gly Pro Asp Val Arg Glu Ile Glu Gln 
        275                 280                 285             


Ala Arg Lys Arg Asp Pro Ala Leu Leu Asp Leu His Met Ala Val Lys 
    290                 295                 300                 


Asp Val Tyr Arg Lys Leu Ile Lys Arg Arg Ala Ala Pro Lys Lys Met 
305                 310                 315                 320 


Arg Leu Ala Gln Ala Leu Pro Lys Ser Arg His Asp Leu Leu Arg Leu 
                325                 330                 335     


Leu Gly His His Asp Arg Asn Arg Asp Leu Ala Ala Leu Ile Arg His 
            340                 345                 350         


Gly Lys Leu Ile His Tyr Thr Ala Ala Asp Leu Ala Ala Arg Asp Ala 
        355                 360                 365             


Gly Gly Ala Gln Glu Pro Gly Asp Arg Pro Ala His Val Leu Thr His 
    370                 375                 380                 


Trp Pro Asp Asp Leu Ser Thr Ser Arg Tyr Leu Thr Ser Glu Gly Gln 
385                 390                 395                 400 


Ser Ala Ile Lys Arg Ser Glu Ala Phe Val Arg His Trp Arg His Thr 
                405                 410                 415     


Ile Ala Leu Ala Ala Leu Thr Leu Arg Asp Trp Ala Ser Met Gly Lys 
            420                 425                 430         


Asp Ile Gly Asp Val Leu Gly Asn Ser Asn Lys Val Gln Glu Ala Thr 
        435                 440                 445             


Gly Lys Gly Asn Phe Arg Ala Asp Met His Asp Ala Lys Val Arg Pro 
    450                 455                 460                 


Leu Phe Gly Ala Arg Ala Ser Leu Phe Pro Ser Asp Asp Asp Ala Gly 
465                 470                 475                 480 


Arg Lys Ala Leu Leu Ala Ser Val Ile Arg Ala Gly Ile Lys Leu Arg 
                485                 490                 495     


Asn Asn Ser Phe His Phe Thr Gly Arg Gly Gly Phe Leu Ala Ala Leu 
            500                 505                 510         


Lys Gly Leu Gly Ser Asp Asp Val Leu Thr Lys Glu Val Arg Ala Ala 
        515                 520                 525             


Ala Leu Ala Leu Trp Arg Glu Asp Ala Gly Ala Arg Ala Gly Arg Val 
    530                 535                 540                 


Arg Ala Ser Leu Thr Ala Val His Ala Pro Asn Tyr Phe Asp Glu Arg 
545                 550                 555                 560 


Gln Asn Arg Val Ile Val Glu Leu Leu Glu Gln Glu Pro Gly Gln Gln 
                565                 570                 575     


Arg Glu Pro Leu Pro Leu Pro Arg Phe Arg Arg Met Leu Ser Arg Ala 
            580                 585                 590         


Glu Gly Ala Trp Lys Gly Lys Ala Gln Leu Arg Leu Pro Lys Thr Ala 
        595                 600                 605             


Asn Arg Val Glu Leu Gln Asp Pro Ala Arg Arg Cys Arg Tyr Val Val 
    610                 615                 620                 


Leu Lys Met Leu Tyr Glu Arg Pro Phe Arg Asp Trp Leu Ala Ala Arg 
625                 630                 635                 640 


Thr His Val Glu Val Asn Arg Trp Ile Asp Arg Ala Leu Lys Arg Ser 
                645                 650                 655     


Thr Glu Ala Ala Gln Thr Asn Tyr Gly Lys Arg Leu Asp Asp Ala Gln 
            660                 665                 670         


Lys Ala Leu Ile Val Ala Lys Ala Asn Lys Leu Pro Arg Leu Ser Glu 
        675                 680                 685             


Gly Arg Arg Ile His Asp Phe Phe Tyr Asp Leu Ser Ser Ala Thr Ala 
    690                 695                 700                 


Ala Glu Met Arg Val Gln Arg Gly Tyr Gly His Asp Gly Glu Ala Ala 
705                 710                 715                 720 


Arg Glu Gln Ala Ser His Ile Asp Asp Leu Leu Cys Asp Val Val Ala 
                725                 730                 735     


Leu Ala Phe Glu Glu Trp Leu His Ala Pro Gln Asp Val Arg Gly Pro 
            740                 745                 750         


Leu Ser Trp Leu Ile Asp Leu Glu Pro Gly Thr Leu Leu Pro Gly Lys 
        755                 760                 765             


Gln Cys Asp Leu Asn Glu Ile Pro Leu Thr Ala Asp Met Lys Gly Pro 
    770                 775                 780                 


Glu Asp Trp Gln Ala Ala Leu Tyr Leu Phe Leu His Leu Val Pro Val 
785                 790                 795                 800 


Gly Glu Ala Ser Arg Leu Leu His Gln Leu Ala Lys Trp Ser Ile Thr 
                805                 810                 815     


Ser Gln Leu Ser Asp Lys Leu Ser Glu Ala Glu Glu Arg Ser Leu Thr 
            820                 825                 830         


Ala Leu Ile Gln Thr Leu Leu Phe Tyr Leu Asp Met His Asp Ala Lys 
        835                 840                 845             


Phe Glu Gly Gly Glu Ala Leu Thr Gly Cys Glu Pro Phe Lys Asp Leu 
    850                 855                 860                 


Phe Glu Ser Pro Ala Gly Phe Glu Lys Val Phe Pro Ala Asp Asn Glu 
865                 870                 875                 880 


Ser Pro Leu Glu Gly Trp Val Pro Lys Arg Gly Leu Arg Glu Ile Met 
                885                 890                 895     


Arg Phe Gly His Arg Arg Leu Val Ala Gly Leu Ala Gln Asp Asp Arg 
            900                 905                 910         


Val Thr Asp Ala Glu Val Asp Ala Phe Leu Arg Val Glu Met Gly Thr 
        915                 920                 925             


Gly Glu Asp Ser Ile Ala Lys Leu Gln Ala Gly Arg Glu Lys Val Asp 
    930                 935                 940                 


Glu Ala Trp Ser Lys Lys Arg Arg Gly Gly Gly Lys Lys Gly Gln Lys 
945                 950                 955                 960 


Lys Ser Asp Ile Thr Ser Glu Met Leu Arg Glu Tyr Val Glu Ala Ile 
                965                 970                 975     


Ala Gly Ile Ala Arg His Arg Arg Met Gly Ala Arg Val Thr Leu Thr 
            980                 985                 990         


Glu Leu Val Thr Leu His Arg Val  Leu Met Ser Val Met  Gly Arg Leu 
        995                 1000                 1005             


Ala Asp  Tyr Ala Gly Met Phe  Glu Arg Asp Leu Tyr  Phe Ala Met 
    1010                 1015                 1020             


Leu Gly  Cys Leu Ala Thr Glu  Arg Ser Glu Ala Ala  Lys Val Leu 
    1025                 1030                 1035             


Asn Pro  Ala Gly Gln Asp Lys  Leu Ser Ser Gly Gln  Ile Ile Asp 
    1040                 1045                 1050             


Ala Leu  Arg Thr Leu Pro Asp  Tyr Arg Tyr Lys Gln  Ala Ala Ser 
    1055                 1060                 1065             


Arg Asp  Gly Pro Gln Val Ala  Ala Thr Ile Lys Glu  Leu Phe Gly 
    1070                 1075                 1080             


Lys Asn  Val Ala Glu Leu His  Ala Phe Arg Ser Arg  Gln Thr Asn 
    1085                 1090                 1095             


Glu Thr  Thr Arg Thr Ser Glu  Asn Pro Arg Gly Pro  Asp Val Asp 
    1100                 1105                 1110             


Glu His  Ala Lys Phe Glu Ser  Leu Ile Ala Ile Arg  Asn Asp Leu 
    1115                 1120                 1125             


Ser His  Leu Asn Ser Leu Asn  Ser Asp Ser Tyr Thr  Leu Asp Leu 
    1130                 1135                 1140             


Thr Ala  Leu Val Asn Gln Thr  Arg Thr Leu Met Ser  Tyr Asp Arg 
    1145                 1150                 1155             


Lys Leu  Lys Asn Ala Val Ser  Gln Ser Ile Lys Glu  Leu Leu Leu 
    1160                 1165                 1170             


Arg Gln  Ser Ile Arg Leu Lys  Trp Gly Thr Thr Asp  Arg His Glu 
    1175                 1180                 1185             


Leu Ala  Asp Ala Lys Ile Ala  Gly Lys Met Ala Lys  His Leu Gly 
    1190                 1195                 1200             


Gly Arg  Lys Leu His Leu Gln  Thr Gly Asp Lys Pro  Glu Val Ile 
    1205                 1210                 1215             


Ser Glu  Asn Leu Cys Ser Glu  His His Leu Lys Ala  Val Ala Lys 
    1220                 1225                 1230             


Leu Phe  Ala Gly Lys Ala Asp  Ile Ala Ser Asp Val  Ala Asp Leu 
    1235                 1240                 1245             


Asp Leu  Asn Thr Val Asp Trp  Ala Thr Pro Asn Glu  Lys Gly Lys 
    1250                 1255                 1260             


Gly Ser  Gln His Ala Pro Ser  Pro Gly Arg Pro Gly  Ser Pro Lys 
    1265                 1270                 1275             


Ala Pro  Arg Arg 
    1280         


<210>  970
<211>  1439
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  970

Met Ala Gly Arg Glu Ile Val Ser Met Lys Ile Thr Lys Val Asn Tyr 
1               5                   10                  15      


Val His Ala Gly Ile Val Arg Glu Gln Asp Pro Arg Asn Gly Lys Leu 
            20                  25                  30          


Tyr Lys Tyr Glu Gly Tyr Gln Ser Gly Lys Asp Thr Gly Ile Glu Ala 
        35                  40                  45              


His Ile Arg Asn Arg Val Glu Ala Ser Gln Lys Leu Phe Ser Ile Leu 
    50                  55                  60                  


Asn Pro Asp Lys Lys Glu Ser Asp Asp Lys Asn Gly Lys Glu Ser Pro 
65                  70                  75                  80  


Glu Gly Ala Asn Gln Lys Gly Ala Gln Lys Gly Ser Asn Gln Ala Glu 
                85                  90                  95      


Ala Gln Glu Lys Thr Glu Glu Glu Lys Lys Ala Glu Glu Glu Glu Lys 
            100                 105                 110         


Arg Lys Lys Glu Leu Glu Lys Gln Lys Asn Ile His Asp Phe Ile Arg 
        115                 120                 125             


Gly Ser Leu Lys Thr Leu Asp Asp Ser Ile Lys Lys Ala Cys Glu Asn 
    130                 135                 140                 


Ala Lys Glu Gly Ser Ser Ala Ala Ala Phe Ala Arg Glu Leu Asp Asp 
145                 150                 155                 160 


Leu Phe Ser Tyr Arg Asn Ala Arg Phe Val Lys Ser Pro Asp Ser Ser 
                165                 170                 175     


Leu Cys Ser Ala Glu Glu Phe Glu Asn Gly Val Gln Glu Phe Val Asp 
            180                 185                 190         


His Tyr Val Arg Arg Pro Leu Thr Ala Thr Val Lys Ser Pro Asp Lys 
        195                 200                 205             


Lys Arg Ser Ile Asp Leu Asn Gln Val Ala Tyr Arg Leu Phe Leu Leu 
    210                 215                 220                 


Tyr Met Thr Ala Gly Lys Asp Glu Ala Gln Tyr Asn Gln Arg Leu Ser 
225                 230                 235                 240 


Glu Ile Asn Gln Glu Asp Arg Asn Ala Phe Tyr Asp Arg Val Leu Glu 
                245                 250                 255     


Ser Tyr Thr Lys Glu Gly Gln Ile Glu Arg Leu Val Thr Ser Ile Ser 
            260                 265                 270         


Asn Lys Thr Val Pro Val Ala Val Asn Glu Ile Asp Gly His Phe Leu 
        275                 280                 285             


Leu Gln Pro Ala Asn Ala Glu Gln Lys Lys Asn Lys Asp Glu Tyr Ser 
    290                 295                 300                 


Ala His His Leu Phe Asp Phe Met Lys Glu Tyr Cys Gly Thr Asp Glu 
305                 310                 315                 320 


Asn Gly Arg Asp Arg Met Val Ser His Ile Arg Tyr Leu Ile Ala Cys 
                325                 330                 335     


Tyr Phe Tyr Gly Lys Ser Thr Val Asp Thr Tyr Ala Ala Gly Gly Cys 
            340                 345                 350         


Leu Lys Asp Ser Phe Lys Gly Leu Ala Gly Asp Gly Ser Val Ser Met 
        355                 360                 365             


Tyr Phe Ser Glu Glu Leu His Glu Lys Leu Tyr Glu Lys Ser Ile Asp 
    370                 375                 380                 


Lys Asp Gly Asn Pro Asn Pro Arg Lys Phe Val Glu Val Asn Gly Ala 
385                 390                 395                 400 


Leu Lys Pro Leu Leu Lys Glu Ala Phe Lys Lys Arg Ile Ile Asp Cys 
                405                 410                 415     


Asn Met Ser Leu Ser Asp Pro Arg Asp Lys Tyr Trp Ile Leu Glu Phe 
            420                 425                 430         


Ile Ser Lys Gln Thr Glu Lys Glu Leu Asp His Ser Lys Leu Arg Pro 
        435                 440                 445             


Glu Asp Leu Asn Asn Tyr Lys Leu Ser Lys Thr Ile Met Asn Ser Trp 
    450                 455                 460                 


Arg Ser Tyr Ile Ser Asp Gln Tyr Ile Ser Met Gly Lys Ala Val Tyr 
465                 470                 475                 480 


His Phe Val Met Gly Lys Asp Ala Ala Leu Ser Lys Arg Pro Asn Val 
                485                 490                 495     


Thr Val Ser Phe Lys Asp Val Lys Asn Glu Phe Thr Lys Gly Ile Thr 
            500                 505                 510         


Ser Phe Glu Tyr Glu Arg Ile Ser Ala Ala Glu Ser Leu Asp Arg Ala 
        515                 520                 525             


Ser Ala Arg Tyr Ile Thr Phe Ala Tyr Asn Asn Phe Arg Arg Ala Val 
    530                 535                 540                 


Leu Lys Ser Phe Ser Glu Thr Ala Asp Gly Asp Glu Asp Ile Leu Asn 
545                 550                 555                 560 


Ile Thr Asp Asp Asn Lys Ile Met Asp Leu Thr Arg Glu Asp Ser Thr 
                565                 570                 575     


Arg Cys Ile Leu Gln Phe Phe Gly Gly Ala Ser Thr Trp Pro Glu Asn 
            580                 585                 590         


Ile Val Asn Lys Asp Arg Met Glu Phe Leu His Thr Met Met Gln Gly 
        595                 600                 605             


Ile Thr Tyr Cys Arg Asn Asn Ala Phe His Phe Ser Val Asn Ser Lys 
    610                 615                 620                 


Ala Thr Glu Met Asp Pro Leu Gly Asn Glu Ile Phe Glu Tyr Glu Lys 
625                 630                 635                 640 


Asp His Leu Gly Gln Val Leu Arg Lys Gln Tyr Tyr Ser Asn Asn Val 
                645                 650                 655     


Pro Met Phe Tyr Ala Val Lys Asp Ile Asp Gly Leu Met Asp Tyr Leu 
            660                 665                 670         


Tyr Gln His Asn Val His Ser Ala Gly Gln Ile Pro Ser Phe Arg Arg 
        675                 680                 685             


Leu Phe Lys Ser Gly Glu Glu Leu Phe Met Ser Leu Glu Leu Ser Thr 
    690                 695                 700                 


Glu Ser Phe Leu His Gly Ala Pro Lys Glu Thr Phe Lys Lys Leu Trp 
705                 710                 715                 720 


Pro Ser Phe Tyr Phe Val Cys Lys Glu Ile Tyr Tyr Tyr Gly Phe Leu 
                725                 730                 735     


Asn Asp Asn Asn Ala Arg Asn Leu Phe Leu Glu Ala Val Ala Asp Ile 
            740                 745                 750         


Gly Asn Ala Asp Tyr Asp Lys Lys His Gln Asn Ala Met Ser Asp Phe 
        755                 760                 765             


Thr Lys Arg Ile Asn Gly Ile Ala Gly Val Asn Ile Tyr Asn Thr His 
    770                 775                 780                 


Lys Asp Ala Asp Pro Phe Val Lys Val Ser Leu Pro Gln Asp Asp Ser 
785                 790                 795                 800 


Ser Leu Thr Leu Asp Val Ile Cys Gln Thr Leu Met Thr Glu Tyr Glu 
                805                 810                 815     


Gln Gln Asn Asn Gly Lys Thr Val Ile Ala Lys Phe Gly Glu Glu Lys 
            820                 825                 830         


Lys Phe Lys His Tyr Arg Asp Leu Leu Tyr Ser Gly Leu Ala Leu Ala 
        835                 840                 845             


Phe Val Asn Tyr Leu Lys Arg Gln Ala Ala Tyr Ala Phe Leu Leu Ala 
    850                 855                 860                 


Pro Lys Asp Arg Thr Glu Thr Phe Ala Lys Leu Ser Glu Glu Glu Phe 
865                 870                 875                 880 


Thr Gly Ser Trp Asn Asn Ile His Val Phe Asp His Phe Leu Glu Lys 
                885                 890                 895     


Glu Lys Ile Leu Ser Lys Lys Gln Lys Gln Arg Met Lys Gly Asn Ile 
            900                 905                 910         


Glu Ala Pro Lys Glu Lys Lys Ala Leu Asp Ser Tyr Leu Thr Ala Trp 
        915                 920                 925             


Tyr Leu Thr Ala His Phe Leu Ser Ser Arg Gln Leu Asn Leu Leu Val 
    930                 935                 940                 


Gly Ala Phe Arg Ser Tyr Ile Gln Tyr Lys Glu Asn Ile Glu Trp Arg 
945                 950                 955                 960 


Ala Ala Thr Leu Asn His Gly Asp Ala Lys Tyr Asn Lys Asp Val Lys 
                965                 970                 975     


Gly Thr Ile Asn Thr Cys Lys Ser Ile Val Glu Ile Leu Glu Leu Val 
            980                 985                 990         


Arg Asn Phe Ser Gly Lys Phe Ser  Asn Glu Ile Thr Asp  Tyr Phe Thr 
        995                 1000                 1005             


Thr Glu  Asp Glu Tyr Ala Glu  Tyr Val Gly Lys Phe  Val Asp Leu 
    1010                 1015                 1020             


Gly Glu  Ala Pro Thr Lys Asp  Thr Leu Leu Arg Phe  Ala Asn Thr 
    1025                 1030                 1035             


Gln Val  Leu Asn Gly Gln Lys  Ile Gly Ile Tyr Ala  Asp Ala Glu 
    1040                 1045                 1050             


Asn Leu  Ile Met Leu Arg Gly  Ile Ala Ile Ala Lys  Met Phe Gly 
    1055                 1060                 1065             


Asn Ala  Asp Leu Leu Ala Lys  Cys Trp Asn Lys Ile  Thr Phe Glu 
    1070                 1075                 1080             


Glu Tyr  Glu Ala Tyr Tyr Glu  Gln Gln Leu Lys Leu  Thr Asp Tyr 
    1085                 1090                 1095             


Tyr Lys  Asn Gly Arg Cys Thr  Ser Glu Glu Glu Leu  Lys Asp Leu 
    1100                 1105                 1110             


Leu Gly  Tyr Gln Lys Met Lys  Asn Arg Leu Glu Leu  Tyr Ser Val 
    1115                 1120                 1125             


Ser Glu  Tyr Thr Glu Ile Leu  Asn Asp Leu Tyr Ser  Gln Leu Val 
    1130                 1135                 1140             


Ser Trp  Ser Tyr Leu Arg Glu  Arg Asp Phe Met Tyr  Met Leu Leu 
    1145                 1150                 1155             


Gly Tyr  His Tyr Ile Glu Leu  Tyr Tyr Thr Asp Arg  Val Pro Glu 
    1160                 1165                 1170             


Asn Asp  Leu Ser Arg Arg Met  Thr Gly Ser Cys Val  Leu Glu Asp 
    1175                 1180                 1185             


Asn Ile  Gly Lys His Ser Gly  Asn Asp Ala Ala Pro  Ala Ser Val 
    1190                 1195                 1200             


Glu Tyr  Phe Trp Asn Ile Thr  Asp Gly Ala Ile Leu  Tyr Glu Ile 
    1205                 1210                 1215             


Leu Ala  Ala Asn Asp Arg Thr  Ile Pro Leu Val Lys  Ala Asn Ala 
    1220                 1225                 1230             


Lys Lys  Pro Ser Gly Phe Glu  Ala Ser Thr Lys Gly  Thr Ile Gly 
    1235                 1240                 1245             


Ser Arg  Tyr Gly Asn Ile Met  Ser Thr Phe Arg Glu  Ser Ala Phe 
    1250                 1255                 1260             


Asp Phe  Thr Asp Gly Leu Asp  Leu Phe Val Arg Thr  Thr Ala Lys 
    1265                 1270                 1275             


Ala Asn  Lys Val Lys Gly Gln  Asp Glu Tyr Asp Asp  Cys Val Ser 
    1280                 1285                 1290             


Phe Arg  Asn Ala Ile Asp His  Phe Lys Tyr Phe Ser  Lys Pro Lys 
    1295                 1300                 1305             


Glu Ser  Met Val Glu Met Tyr  Arg Arg Val Tyr Asp  Glu Phe Phe 
    1310                 1315                 1320             


Thr Tyr  Asp Val Lys Leu Arg  Lys Ser Val Ser Phe  Ile Phe Lys 
    1325                 1330                 1335             


Asn Ile  Leu Ala Asp His Phe  Val Val Ala Asp Thr  Ala Met Arg 
    1340                 1345                 1350             


Ala Asp  His Gln Arg Ile Tyr  Asn Leu Tyr Ser Thr  Lys Lys Asp 
    1355                 1360                 1365             


Val Lys  Pro Val Val Ser Glu  Arg Lys Ser Cys Gly  Phe Ser Ile 
    1370                 1375                 1380             


Lys Asp  Ser Leu Lys Ser Met  Lys Phe Thr Tyr Lys  Phe Arg Asp 
    1385                 1390                 1395             


Val His  Asp Val Lys Asp Lys  Val Tyr Glu Tyr Lys  Trp Asp Glu 
    1400                 1405                 1410             


Thr Phe  Leu Asn Thr Leu Gln  Arg Ile Leu Glu Tyr  Ser Glu Pro 
    1415                 1420                 1425             


Asp Pro  Glu Leu Lys Glu Ile  Leu Gly Thr Asp 
    1430                 1435                 


<210>  971
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  971

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Pro Gly Thr Asp Thr 
            20                  25                  30          


Ile Gly Leu Lys Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Asp Lys Pro Lys Lys 
    50                  55                  60                  


Trp Lys Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Glu Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Ser Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Val Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Ser Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Met Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Tyr Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ser Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asp Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Gln Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Phe 
            660                 665                 670         


Ile Arg Lys Asn Phe Pro Glu Asp Ile Ser Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val Tyr Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Asp Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Asp Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asn  Ser Glu Lys Lys Glu  Ala Tyr Gln Lys Ile  Glu Val Asn 
    1100                 1105                 1110             


Gly Asp  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Val  Tyr Ala Pro Asp Glu  Lys Gly Asp 
    1130                 1135                 1140             


Ile Leu  Lys Glu Gln Cys Thr  Lys Gly Gly Ala Gly  Gly Lys Ile 
    1145                 1150                 1155             


Ser Ala  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Lys Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Lys Gln 
    1250                 1255                 1260             


Thr Thr  Ser Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Ser Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Lys  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Val Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Gly Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Pro Asn 
    1370                 1375                 1380         


<210>  972
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  972

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  973
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  973

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Tyr Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  974
<211>  1101
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  974

Met Lys Leu Ser Lys Glu Lys Tyr Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Glu Tyr Ile Arg Ser Ala Val Ala Asn Glu Lys Gln 
        35                  40                  45              


Asn Ile Gly Gly Val Leu Tyr His Ala His Gly Thr Asp Thr Ile Asp 
    50                  55                  60                  


Leu Gln Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Gly Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Thr Asp Arg Val Arg Arg Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Ile Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Glu Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Tyr Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Leu Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Glu Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Gly  Ser Lys Arg Cys Met  Thr Ile Pro Glu Ser  Arg Arg Arg 
    1070                 1075                 1080             


Ala Asp  Cys Leu Ile Arg Val  Arg Arg Ala Gly Lys  Leu Leu Thr 
    1085                 1090                 1095             


Gln Thr  Gly 
    1100     


<210>  975
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  975

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  976
<211>  1234
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  976

Met Arg Ile Ile Lys Pro Tyr Gly Arg Ser Lys Thr Lys Arg Tyr Ser 
1               5                   10                  15      


Ser Gly Thr Glu Arg Arg Leu Gln Pro Asn Pro Ala Leu Arg Asp Gly 
            20                  25                  30          


Glu Ala Met Asp Ala Asp Gly Leu Ser Ile Gly Pro Phe Ala Glu Ser 
        35                  40                  45              


His Asp Ser Leu Val Ile Gly Gln Trp Ile Ser Thr Ile Asp Lys Ile 
    50                  55                  60                  


Ala Thr Lys Pro Lys Gly Lys Gly Lys Ala Thr Gln Glu Gln Arg Asn 
65                  70                  75                  80  


Val Arg Ser Ala Leu Gly Ala Ala Cys Trp Ala Arg Leu Val His Pro 
                85                  90                  95      


Asp Gly Thr Phe Gly Ala Leu Asp Ser Glu Arg Met Asn Trp Ala Arg 
            100                 105                 110         


Asn Thr Trp Glu Arg Arg Leu His Pro Tyr Ser Asp Lys Asn Phe Val 
        115                 120                 125             


Thr Asn Gly Arg Glu Lys Thr Pro Asp Ser Lys Ala His Trp Phe Asn 
    130                 135                 140                 


Arg Phe Cys Lys Gly Leu Ser Val Gln Glu Val Thr Asp Pro Ser Val 
145                 150                 155                 160 


Ala Gly Asp Val Ala Gln Ser Ile Glu Glu His Leu Thr Lys Asp Ala 
                165                 170                 175     


Phe Arg Arg Gly Gly Gly Thr Arg Arg Ser Pro Lys Ala Ser Ala Ser 
            180                 185                 190         


Arg Ala Gly Leu Ile Ala Val Arg Ala Asp Ser Ile Thr Lys Asn Ala 
        195                 200                 205             


Leu Arg Phe Pro Gly Ala Asp Ile Ala Glu Gln Arg Glu His Gly Trp 
    210                 215                 220                 


Thr Glu Glu Asp Ile Ala Arg Tyr Val Ala Lys Ser Asp Pro Val Ala 
225                 230                 235                 240 


Gln Ile Tyr Lys Ala Val Leu Asp Ala Glu Pro Asp Gly Gln Arg Val 
                245                 250                 255     


Arg Trp Ser Ile Ala Ala Glu Arg Leu Tyr Ala His Tyr Ala Arg Val 
            260                 265                 270         


Phe Thr Ala Pro Asp Ile Val Leu Asp Arg Lys Asp Ala Asp Lys Ile 
        275                 280                 285             


Leu Arg Gly Val Leu Ala Leu His Glu Ala Leu Arg Gln Leu Tyr Arg 
    290                 295                 300                 


His Arg Leu Lys Arg His Arg Arg Lys Pro Val His Val Thr Val Leu 
305                 310                 315                 320 


Leu Pro Arg Asp Ile Arg Asp Ala Leu Thr Met Ile Ser Arg Gln Gln 
                325                 330                 335     


Asp Asn Ser Asp Leu Asn Ala Leu Val Arg Leu Gly Lys Val Ile His 
            340                 345                 350         


His Glu Ala Ala Asp Gln Ala Gly Val Glu Ser Val Ala Lys Ile Ile 
        355                 360                 365             


Gly Asn Trp Pro Glu Asp Val Ser Arg Ser Tyr Tyr Trp Thr Ser Asp 
    370                 375                 380                 


Gly Gln Thr Glu Ile Lys Arg Thr Glu Ala Phe Val Arg Ala Trp Arg 
385                 390                 395                 400 


Gly Pro Ile Ala His Ala Gln Arg Thr Leu Ala Asp Trp Val Asp Pro 
                405                 410                 415     


Asp Arg Leu Ser Val Lys Ser Asp Ser Ala Glu Ala Lys Pro Pro Asp 
            420                 425                 430         


Met Leu Gly Ala Lys Phe Asp Asp Ala Leu Ala Gln Leu Asp Asp Asp 
        435                 440                 445             


Ala Ala Ile Thr Lys Ala Arg Leu Leu Phe Gly Thr Arg Ser Asp Ala 
    450                 455                 460                 


Leu Gly Gly Pro Asp Pro Lys Ala Val Leu Arg Leu Thr Lys Arg Ala 
465                 470                 475                 480 


Leu Ser Lys Leu Arg Asn Ala Ala Phe His Phe Lys Gly Met Gly Gly 
                485                 490                 495     


Phe Val Gln Asp Met Thr Leu Lys Ile Leu Pro Ser Gly Ser Glu Asp 
            500                 505                 510         


Cys Glu Val Leu Glu Arg Val His Ala Leu Trp His Ala Asp Gln Lys 
        515                 520                 525             


Asp Arg Met Ile Arg Val Lys Asp Ala Leu Val Gly Ala His Ala Glu 
    530                 535                 540                 


Val Tyr Leu Asn Gln Pro Gln Met Asn Gln Leu Trp Glu Leu Leu Gly 
545                 550                 555                 560 


Ala Gln Glu Ser Lys Ile Ala Leu Pro Arg Phe Asn Arg Val Ile Ala 
                565                 570                 575     


Arg Ala Ala His Ala Trp Thr Ser Lys Glu Asp Arg Leu Ala Leu Pro 
            580                 585                 590         


Asp Ser Ala Ser Ser Lys Asp Leu Glu Ala Gln Pro Ala Arg Arg Cys 
        595                 600                 605             


Gln Tyr Val Leu Ile Lys Met Val Tyr Glu Arg Gly Phe Arg Thr Trp 
    610                 615                 620                 


Leu Thr Ser Arg Ser Ala Asp Asp Leu Asn Ile Trp Ile Lys Gln Ala 
625                 630                 635                 640 


Thr Asp His Thr Thr Glu Ala Ala Lys Glu Phe His Lys His Gln Val 
                645                 650                 655     


Ser Lys Glu Glu Leu Ala Gln Ile Ser Ala Arg Ser Ala Gly Leu Val 
            660                 665                 670         


Lys Leu Glu Pro Gly Glu Gly Phe Ala Lys Phe Leu Phe Lys Met Thr 
        675                 680                 685             


Ala Leu Thr Thr Thr Glu Phe Arg Val Gln Lys Gly Tyr Thr His Asp 
    690                 695                 700                 


Ala Gly Arg Ala Arg Glu Gln Ala Ser Phe Leu Asp Asp Leu His Cys 
705                 710                 715                 720 


Asp Leu Val Ala Leu Ala Phe Asp Thr Tyr Leu Lys Asp Lys Lys Leu 
                725                 730                 735     


Gly Trp Leu Tyr Arg Leu Arg Gln Asp Glu Ser Pro Gly Asn Pro Gln 
            740                 745                 750         


Ser Ser Ala Ala Asp Leu Pro Leu Gly Ser Val Ala Ser Ala Gln Asp 
        755                 760                 765             


Trp Gln Ala Val Leu Tyr Leu Val Leu His Leu Ile Pro Val Asp Asp 
    770                 775                 780                 


Val Gly Arg Leu Leu His Arg Trp Arg Trp Trp Ser Asn Lys Tyr Asp 
785                 790                 795                 800 


Asp Glu His Leu Pro Ala Glu Gly Leu Gln Leu Ala Glu Ala Phe Thr 
                805                 810                 815     


Leu Tyr Leu Asp Met His Asp Ala Lys Phe Asp Gly Ala Glu Ala Ile 
            820                 825                 830         


Thr Gly Ser Ala Ala Phe His Asp Leu Phe Asp Ser Asp Thr Thr Arg 
        835                 840                 845             


Lys Gln Val Phe Pro Asp Ala Leu Ala Ala Glu Ala Glu Gly Pro Arg 
    850                 855                 860                 


Gln Ile Met Gln Arg Gly Leu Arg Glu Met Leu Arg Phe Gly Asp Met 
865                 870                 875                 880 


Ala Ser Phe Ala Pro Val Phe Ala Gly Arg Lys Val Thr Ala Glu Gln 
                885                 890                 895     


Val Lys Glu Trp Gln Asn Leu Asp Ala Gln Val Ala Ala Ala His Glu 
            900                 905                 910         


Thr Arg Lys Lys Val His Glu Asp Tyr Lys Arg Gly Leu Arg Pro Ser 
        915                 920                 925             


Thr Glu Asn Glu Arg Leu Leu Glu Gln Lys Tyr Asp Leu Ala Ala Tyr 
    930                 935                 940                 


Val Lys Ala Val Lys Thr Ile Thr Arg His Lys Arg Leu Ser His His 
945                 950                 955                 960 


Val Lys Leu Thr Asn His Val Arg Leu His Gln Ile Val Met Arg Val 
                965                 970                 975     


Leu Gly Arg Leu Val Asp Tyr Ala Gly Leu Trp Glu Arg Asp Val Tyr 
            980                 985                 990         


Phe Val Leu Leu Ala Leu Ile Cys  Leu Arg Gly Gln Thr  Pro Arg Asp 
        995                 1000                 1005             


Val Phe  Gln Asn Ala Tyr Gly  Arg Lys Ala Leu Arg  Gly Gly Gln 
    1010                 1015                 1020             


Ile Arg  Lys Ala Val Gln Asn  Leu Glu Pro Glu Tyr  Lys Thr Ala 
    1025                 1030                 1035             


Leu Glu  Arg His Phe Gly Thr  Gly Ala Phe Glu Glu  Gly Gly Val 
    1040                 1045                 1050             


Val Thr  Ile Arg Asn Asp Leu  Ala His Leu Asn Met  Met Gly Arg 
    1055                 1060                 1065             


Ala Ala  Arg Ser Asp Asp Ala  Arg Val Pro Leu Asp  Leu Thr Cys 
    1070                 1075                 1080             


Gln Ile  Asp Arg Thr Arg Arg  Leu Met Ser Tyr Asp  Arg Lys Leu 
    1085                 1090                 1095             


Gln Asn  Ser Val Ser Lys Ser  Val Thr Asp Leu Met  Glu Arg Glu 
    1100                 1105                 1110             


Lys Ile  Arg Leu Ser Phe Arg  Leu Asp Lys Gly Lys  Leu Thr Gln 
    1115                 1120                 1125             


Ala Thr  Val Lys Ala Asp Leu  Ile Lys His Phe Lys  Arg Lys Glu 
    1130                 1135                 1140             


Leu Thr  Glu Asn Leu His Asp  Pro Leu Phe Leu Gly  Met Val Ala 
    1145                 1150                 1155             


Asp Val  Tyr Gly Gly Thr Val  Gly Gln Leu Gln Asn  Asp Leu Thr 
    1160                 1165                 1170             


Asp Ala  Gln Asp Ile Ala Ala  Val Val Asn Gln Thr  Phe Ala Ala 
    1175                 1180                 1185             


Val Lys  Ala Glu Gln Asp Ala  Arg Arg Arg Pro Arg  Asn Asn Arg 
    1190                 1195                 1200             


Ala Gln  Ser Gln Asn Pro Gly  Gly Gly Thr Arg Arg  Asn Gly Gly 
    1205                 1210                 1215             


Lys Glu  Lys Tyr Gly Lys His  Pro Lys Gly Lys Arg  Thr Asp Arg 
    1220                 1225                 1230             


His 
    


<210>  977
<211>  1330
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  977

Met Lys Arg Glu Lys Asn Ile Thr Ile Met Lys Ile Ser Lys Val Asn 
1               5                   10                  15      


His Arg Arg Met Ala Val Ala Leu Asn Gly Asp Lys Ser Glu Leu Gly 
            20                  25                  30          


Gly Ile Leu Tyr Glu Ala Pro Val Gln Lys Asp Lys Asn Gly Asn Tyr 
        35                  40                  45              


Asn Asp Val Ile Ala Glu Thr Gly Lys Val Val Asn Glu Ala Leu Asp 
    50                  55                  60                  


Lys Lys Ser Arg Leu Tyr Thr Pro Phe Asn Asn Gln Lys Val Ile Ile 
65                  70                  75                  80  


Asp Lys Asn Leu Gln Arg Tyr Ala Asn Asn Leu Lys Arg Cys Tyr Ile 
                85                  90                  95      


Asn Phe Val Lys Gln Tyr Val Asn Asn Lys Ser Phe Asn Tyr Lys Ala 
            100                 105                 110         


Met Gln Phe Ile Pro Asp Ile Gln Asn Pro Lys Thr Asn Asp Ala Val 
        115                 120                 125             


Asn Tyr Arg Thr Asp Arg Asp Asn Val Tyr Asn Lys Asn Lys Tyr Tyr 
    130                 135                 140                 


Asp Lys Gln Thr Lys Ser Lys Ser Lys Lys Phe Ile Tyr Glu Lys Ile 
145                 150                 155                 160 


Val Ile Pro Gln Asn Glu Gln Asn Ile Val Ile Ser Ala Leu Val Asn 
                165                 170                 175     


Cys Ser Leu Arg Lys Ser Leu Arg Lys Asp Val Ser Tyr Lys Thr Lys 
            180                 185                 190         


Ser Gly Glu Ile Lys Thr Tyr Asn Leu Pro Glu Leu Val Lys Lys Ser 
        195                 200                 205             


Met Arg Phe Tyr Cys Leu Glu Gly Gln Arg Glu Pro Asp Glu Lys Glu 
    210                 215                 220                 


Lys Tyr Glu Met Tyr Ile Leu Phe Ser Tyr Met Lys Glu Asp Lys Arg 
225                 230                 235                 240 


Thr Lys Asn Thr Asp Leu Leu Val Lys Ser Ile Ser Asn Gln Asn Thr 
                245                 250                 255     


Lys Val Lys Val Glu Asp Ile Asp Gly Asn Lys Leu Leu Lys Leu Ser 
            260                 265                 270         


Ile Ala Asp Thr Lys Lys Lys Pro Leu Trp Glu Tyr Leu Ile Lys Tyr 
        275                 280                 285             


Ala Asp Ser Ser Arg Gln Arg Glu Leu Met Tyr Asp Ile Arg Lys Lys 
    290                 295                 300                 


Ile Val Leu Tyr Val Val Gly Ile Glu Glu Tyr Glu Asn Ile Lys Glu 
305                 310                 315                 320 


Asp Ser Gly Leu Ser Lys Val Ser Trp Ser Lys Tyr Asn Ile Ser Asp 
                325                 330                 335     


Asn Lys Met Phe Val Asp Ile Asn Ser Cys Thr Asp Lys Arg Lys Gln 
            340                 345                 350         


Asn Leu Glu Leu Lys Ile Arg Glu Ala Asn Ile Glu His Tyr Arg Asn 
        355                 360                 365             


Ala Ser Ser Lys Leu Cys Asp Asp Glu Ser Ile Phe Trp Phe Gln His 
    370                 375                 380                 


Phe Glu Gly Val Ile Glu Thr Leu Phe Ser Lys Lys Ser Lys Ile Ser 
385                 390                 395                 400 


Glu Glu Arg Leu Gly Cys Ala Tyr Ile Cys Asp Tyr Leu Trp Lys Asp 
                405                 410                 415     


Phe Leu Ser Tyr Leu Ala Ala Lys Tyr Ile Asp Leu Gly Lys Gly Val 
            420                 425                 430         


Tyr His Phe Thr Met Lys Asp Lys Leu Asp Met Leu Asn Lys Asn Glu 
        435                 440                 445             


Ala Val Thr Asp Leu Arg Phe Gly Ile Val Ser Glu Lys Tyr Glu Lys 
    450                 455                 460                 


Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Glu Leu 
465                 470                 475                 480 


Asp Arg Asn Ile Ala Ala Tyr Val Thr Phe Ala Ala Asp Ile Phe Ala 
                485                 490                 495     


Lys Ser Val Ile Lys Ser Asp Tyr Arg Thr Lys Lys Asp Asn Asn Ser 
            500                 505                 510         


Asp Val Leu Gln Tyr Ser Asp Lys Glu Phe Arg Asn Ser Glu Val Ile 
        515                 520                 525             


Arg Asp Asn Ala Glu Lys Asn Ile Leu Gln Tyr Trp Gly Gly Tyr Ser 
    530                 535                 540                 


Arg Trp Gly Thr Glu Asn Ser Lys Leu Pro Glu Asn Asn Lys Val Ser 
545                 550                 555                 560 


Asp Phe Gly Lys Leu Asp Val Ser Asp Leu Cys Ile Asp Ile Lys Lys 
                565                 570                 575     


His Leu Ala Gly Ile Arg Asn Ser Ser Val His Tyr Thr Thr Lys Ile 
            580                 585                 590         


Lys Asn Glu Ser Ala Ala Asp Gly Ser Asn Val Lys Ile Leu Phe Glu 
        595                 600                 605             


Lys Asp Leu Ala Asp Ile Asn Ile Ile Tyr Ala Asp Lys Tyr Tyr Ser 
    610                 615                 620                 


Asn Asn Val Trp Met Phe Tyr Ser Leu Glu Asp Ile Asn Lys Leu Ile 
625                 630                 635                 640 


Ala Phe Leu Tyr Lys Glu Lys Arg Val Ile Arg Gln Val Gln Ile Pro 
                645                 650                 655     


Ser Phe Ser Arg Ile Leu Lys Arg Lys Ala Met Gln Asp Val Ile Asn 
            660                 665                 670         


Glu Ile Phe Lys Asp Asp Phe Asp Glu Asn Ile Val Asn Pro Glu Leu 
        675                 680                 685             


Lys Glu Lys Tyr Arg Asn Ser Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
    690                 695                 700                 


Tyr Asn Ala Phe Ile Ile Gln Pro Glu Leu Lys Glu Lys Phe Lys Asp 
705                 710                 715                 720 


Lys Ile Lys Thr Met Lys Ser Glu Leu Tyr Asn Lys Leu Lys Thr Ile 
                725                 730                 735     


Asp Lys Lys Glu Tyr Lys Ala Leu Tyr Cys Met Leu Ser Asn Glu Glu 
            740                 745                 750         


Ser Ala Leu Lys Asn Phe Ala Asp Arg Ile Tyr Ser Val Asp Gly Asp 
        755                 760                 765             


Asn Val Ser Phe Ala Asp Ile Cys Lys Ile Leu Met Thr Asp Tyr Asn 
    770                 775                 780                 


Met Gln Asn Gln Glu Lys Lys Asn Ile Glu Ser Met Glu Gln Lys Lys 
785                 790                 795                 800 


Lys Asn Lys Gly Lys Asp Glu Asn Tyr Lys His Phe Pro Leu Leu Leu 
                805                 810                 815     


His Lys Val Leu Lys Glu Leu Phe Ile Glu Tyr Leu Lys Gln Thr His 
            820                 825                 830         


Glu Leu Glu Phe Leu Arg Asn Asn Ile Cys Ile Lys Ser Asp Val Thr 
        835                 840                 845             


Met Glu Ser Phe Glu Ser Gln Ile Lys Gly Val Glu Ile Tyr Lys Asp 
    850                 855                 860                 


Leu Lys Glu Lys Ile Asp Lys Asn Asn Ser Leu Leu Asp Trp Tyr Val 
865                 870                 875                 880 


Ile Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asn 
                885                 890                 895     


Ile Lys Asn Tyr Ile Gln Phe Ala Thr Asn Ile Asp Lys Arg Ala Glu 
            900                 905                 910         


Ser Val Lys Asn Leu Thr Glu Ser Gly Met Val Lys Arg Ile Gln Tyr 
        915                 920                 925             


Tyr Asp Asp Ile Val Arg Thr Leu Glu Phe Ser Ala Gln Tyr Ile Gly 
    930                 935                 940                 


Lys Ile Ser Asn Asn Ile Asn Asp Tyr Phe Asn Ser Glu Asp Glu Tyr 
945                 950                 955                 960 


Val Ser Phe Leu Ser Lys Tyr Val Gly Phe Ile Asn Asp Lys Ser Glu 
                965                 970                 975     


Asp Val Leu Thr Glu Leu Lys Asp Phe Cys Arg Glu Lys Ile Asn Asn 
            980                 985                 990         


Gly Ser Gln Ile Ile Gly Ile Tyr  Tyr Gly Gly Asp Asn  Val Ile Ile 
        995                 1000                 1005             


Asn Arg  Asn Val Ile Tyr Ala  Gln Met Tyr Ser Asn  Ala Glu Val 
    1010                 1015                 1020             


Phe Ser  Asn Ile Tyr Lys Lys  Val Thr Lys Asn Asp  Ile Ile Asn 
    1025                 1030                 1035             


Tyr Tyr  Glu Lys Gln Asn Asp  Leu Lys Asp Val Phe  Lys Ser Gly 
    1040                 1045                 1050             


Val Cys  Gln Asn Glu Gly Glu  Gln Arg Ser Leu Cys  Glu Phe Gln 
    1055                 1060                 1065             


Gln Leu  Lys Asn Arg Ile Glu  Leu Thr Glu Leu Ser  Thr Tyr Ala 
    1070                 1075                 1080             


Asp Met  Val Asn Asp Phe Met  Ala Gln Phe Val Glu  Trp Ala Tyr 
    1085                 1090                 1095             


Leu Arg  Glu Arg Asp Leu Met  Tyr Phe Gln Leu Gly  Ile His Tyr 
    1100                 1105                 1110             


Ile Arg  Leu Phe Tyr Ser Asp  Asn Val Leu Asp Glu  Lys Tyr His 
    1115                 1120                 1125             


Lys Leu  Ser Asp Asn Val Ile  Asp Ile Glu Glu Gly  Ala Leu Leu 
    1130                 1135                 1140             


Tyr Gln  Ile Val Ala Met Tyr  Asp Tyr Glu Leu Arg  Ile Phe Glu 
    1145                 1150                 1155             


Thr Asp  Asn Ser Gly Asn Ala  Lys Arg Ile Gly Gln  Gly Gly Pro 
    1160                 1165                 1170             


Gly Lys  Ser Ile Pro Val Phe  Leu Lys Lys Tyr Cys  Asn Gly Thr 
    1175                 1180                 1185             


Asp Val  Tyr Glu Cys Gly Leu  Glu Leu Phe Glu Asp  Ile Asn Gln 
    1190                 1195                 1200             


His Glu  Asn Ile Ile Gly Phe  Arg Asn Asp Ile Ala  His Met Arg 
    1205                 1210                 1215             


Tyr Met  Ser Asn Gln Ala Met  Asn Ile Met Ser Ile  Val Ser Asn 
    1220                 1225                 1230             


Ile Tyr  Lys Ser Phe Phe Val  Tyr Asp Thr Lys Leu  Lys Lys Ser 
    1235                 1240                 1245             


Ile Ser  Leu Val Phe Lys Asn  Ile Leu Met Arg Tyr  Gly Val Ile 
    1250                 1255                 1260             


Ala Asp  Leu Val Phe Ser Tyr  Asn Asn Lys Asn Gln  Ser Ile Lys 
    1265                 1270                 1275             


Asp Asp  Met Asp Ile Asn Ile  Ile Asn Ile Lys Asn  Leu Lys Ser 
    1280                 1285                 1290             


Asp Lys  Tyr Val Tyr Lys Ile  Val Asn Glu Asp Ile  Val Lys Gln 
    1295                 1300                 1305             


Val Glu  Ile Glu Ile Arg Asn  Gln Val Phe Leu Glu  Gln Leu His 
    1310                 1315                 1320             


Asn Leu  Leu Tyr Phe Ser Arg  
    1325                 1330 


<210>  978
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  978

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu Tyr Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Asn Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Tyr Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Leu Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Val Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Val 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Arg Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Lys Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Val Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Leu Lys Glu Leu Lys Glu Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn Tyr Arg Met Gln Gln Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Lys Lys Asp Glu Lys Phe Asn Asp Lys Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Lys Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Val Lys Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Lys Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Glu  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  979
<211>  1366
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  979

Met Lys Leu Ser Lys Glu Asn His Ile Arg Ser Ala Val Val Ile Ser 
1               5                   10                  15      


Gly Lys Glu Gly Asn Ile Ala Gly Thr Leu Tyr Lys Ile Pro Gly Glu 
            20                  25                  30          


Gly Thr Val Asp Leu Lys Lys Arg Met Leu Glu Arg Asp Lys Ala Val 
        35                  40                  45              


Lys Ser Leu Tyr Asn Ile Phe Asn Gln Ile Gln Leu Gly Asn Glu Pro 
    50                  55                  60                  


Lys Glu Trp Lys Glu Asn Arg Asn Leu Ser Thr Glu Glu Asn Thr Arg 
65                  70                  75                  80  


Arg Met His Gln Lys Lys Val Lys Ile Gln Asn Tyr Lys Met Lys Lys 
                85                  90                  95      


Ala Cys Ser Arg Tyr Val Asn Thr Ile Ser Arg Thr Ile Asn Glu Leu 
            100                 105                 110         


Leu Phe Phe Tyr Lys Thr Thr Lys Thr Thr Gln Asn Asn Lys Val Lys 
        115                 120                 125             


Tyr Asp Lys Leu Lys Met Met His Lys Asn Glu Asp Ile Ile Ser Lys 
    130                 135                 140                 


Met Lys Asn Glu Asn Ile Leu Gln Gln Phe Lys Val Glu Gly Lys Asn 
145                 150                 155                 160 


Gly Lys Leu Glu Lys Gly Lys Leu Glu Asp Phe Val Thr Leu Ala Leu 
                165                 170                 175     


Arg Ser Ser Leu Val Val Ser Arg Tyr Lys Gly Lys Asp Phe Asp Ser 
            180                 185                 190         


Val Ala Ala Val Ala Val Phe Leu Glu Asn Ile Gly Asn Asn Asn Ile 
        195                 200                 205             


Ser His Glu Asp Glu Arg Thr Ile Asn Ile Leu Leu Asp Leu Ile Arg 
    210                 215                 220                 


Glu Asp Phe Thr Lys Leu Asn Pro Asn Ile Asp Asn Thr Met Gly Ala 
225                 230                 235                 240 


Arg Leu Ile Arg Ser Val Thr Asn Gln Asn Met Leu Val Gln Pro Gln 
                245                 250                 255     


Asn Asp Arg Phe Ser Phe Pro Cys Val His Asp Ser Gly Lys Ser Lys 
            260                 265                 270         


Val Ser Asn Lys Asn Val Glu Lys Ser Gly Leu Asp Asn Phe Leu Leu 
        275                 280                 285             


Asp Tyr Ala Asn Leu Asp Lys Asp Ile Arg Glu Asn Tyr Leu Arg Lys 
    290                 295                 300                 


Leu Arg Arg Ile Ile Asp Ile Tyr Phe Ser Ala Pro Ile Thr Tyr Gln 
305                 310                 315                 320 


Lys Asp Met Asp Val Ala Leu Ser Glu Val Val Val Lys Asp Lys Phe 
                325                 330                 335     


Asp Val Trp Lys Lys His Asn Glu Gly Lys Lys Asp Asn Asn Thr Phe 
            340                 345                 350         


Val Lys Val Pro Glu Val Leu Ile Lys Ala Glu Thr Asp His Glu Lys 
        355                 360                 365             


Leu Asp Thr Val Ile Glu Lys Gln Ala Arg Lys Glu Leu Ala Asp Arg 
    370                 375                 380                 


Val Arg Glu Gln Asn Met Thr Cys Tyr Arg Tyr Thr Gln Ala Val Val 
385                 390                 395                 400 


Lys Lys Tyr Asn Ala Lys Glu Ala Leu Phe Phe Glu Asn Asp Asp Ile 
                405                 410                 415     


Asn Gln Tyr Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu 
            420                 425                 430         


Lys Ser Cys Lys Ile Gly Thr Leu Phe Lys Leu His Asn Gly Tyr Leu 
        435                 440                 445             


Ile Glu Lys Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr 
    450                 455                 460                 


Ile Ala Leu Gly Lys Val Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp 
465                 470                 475                 480 


Asn Asp Asn Lys Val Lys Arg Leu Gly Asp Ile Ser Glu Lys Ile Arg 
                485                 490                 495     


Ser Gly Ile Thr Ser Phe Asp Tyr Glu Met Leu Lys Ala Gln Glu Thr 
            500                 505                 510         


Leu Gln Arg Glu Leu Ala Val Asn Val Ala Phe Ser Ala Asn Asn Leu 
        515                 520                 525             


Ala Arg Ala Val Cys Asn Met Ser Ala Leu Ser Asp Lys Thr Ser Asp 
    530                 535                 540                 


Phe Leu Leu Trp Gln Pro Asp Asp Ile Asn Asn Lys Met Lys Lys Ser 
545                 550                 555                 560 


Thr Gly Asn Asp Glu Asp Asn Glu Lys Asn Lys Arg Ala Val Cys Ala 
                565                 570                 575     


Val Leu Gln Phe Phe Gly Gly Lys Ser Leu Trp Asn Asp Val Asp Phe 
            580                 585                 590         


Glu Lys Ala Tyr Lys Asn Ala Gly Lys His Gly Tyr Gly Val Tyr Phe 
        595                 600                 605             


Ile Asn Asp Leu Arg Lys Ala Ile Phe Ala Ala Arg Asn Glu Ser Phe 
    610                 615                 620                 


His Phe Lys Thr Ala Ser Val Asn Asn Glu Lys Trp Asn Val Glu Phe 
625                 630                 635                 640 


Leu Gly Arg Met Phe Glu Lys Glu Thr Glu Phe Cys Leu Asp Ile Glu 
                645                 650                 655     


Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Met Phe Tyr Lys Ser Ser 
            660                 665                 670         


Asn Leu Glu Lys Met Leu Asn His Phe Tyr Ser Lys Asn Ile Ser Arg 
        675                 680                 685             


Ala Ala Gln Val Leu Ser Tyr Asn Thr Val Phe Val Arg Lys Thr Phe 
    690                 695                 700                 


Pro Glu Tyr Val Asn Asn Val Leu Lys Tyr Lys Lys Pro Gly Thr Asp 
705                 710                 715                 720 


Ala Glu Ile Leu Asp Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu Leu Lys 
                725                 730                 735     


Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Lys Asp Ala Phe Lys Tyr 
            740                 745                 750         


Phe Glu Asn Ala Val Tyr Asn Leu Asn Ser Lys Asn Ile Asn His Asp 
        755                 760                 765             


Ser Ser Gly Gln Lys Leu Ser Arg Asp Glu Met Lys Arg Lys Lys Ala 
    770                 775                 780                 


Ala Glu Ser Phe Gln Arg Arg Phe Val Glu Ile Lys Arg Val Ser Asp 
785                 790                 795                 800 


Ser Ser Ile Ser Tyr Val Cys Gln Val Phe Met Thr Asp Tyr Asn Gln 
                805                 810                 815     


Gln Asn Asn Gln Asn Lys Lys Val Arg Ser Ser Asn Asp Ser Leu Leu 
            820                 825                 830         


Asp Lys Pro Ile Tyr Gln His Phe Lys Met Leu Leu Lys Glu Thr Ile 
        835                 840                 845             


Lys Ser Ala Phe Ala Ala Tyr Leu Lys Asp Asn Asn Asn Lys Asp Leu 
    850                 855                 860                 


Phe Gly Phe Ile Gly Glu Pro Leu Lys Ile Asn Lys Asn Asp Asp Val 
865                 870                 875                 880 


Lys Val Ile Lys Lys Glu Glu Phe Leu Pro Asp Trp Lys Ser Glu Lys 
                885                 890                 895     


Tyr Ser Leu Leu Ile Glu Lys Val Lys Lys Ser Pro Lys Leu Gln Met 
            900                 905                 910         


Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met 
        915                 920                 925             


Ala Gly Ser Met Arg Ser Tyr Leu Gln Tyr Val Ser Asp Ile Asn Arg 
    930                 935                 940                 


Arg Ala Asn Val Val Gly Asn Lys Leu His Val Glu Val Leu Asp Lys 
945                 950                 955                 960 


Asp Thr Val Lys Asp Trp Ile Gln Val Ile Glu Val Cys Leu Leu Leu 
                965                 970                 975     


Ala Ser Arg Thr Ser Asn Gln Phe Asp Asp Tyr Phe Asn Asp Gly Asp 
            980                 985                 990         


Asp Tyr Ala Gly Tyr Leu Lys Ser  Tyr Val Asp Phe Ser  Asp Lys Asn 
        995                 1000                 1005             


Met Pro  Ser Ala Tyr Ser Ala  Leu Val Tyr Phe Ser  Asp Gln Gly 
    1010                 1015                 1020             


Lys Ile  Asp Leu Tyr Ile Asp  Pro Lys Asn Pro Lys  Ile Asn Arg 
    1025                 1030                 1035             


Asn Ile  Val Gln Ser Lys Leu  Phe Ala Ala Asp His  Ile Leu Gly 
    1040                 1045                 1050             


Asn Gly  Gln Ile Val Gln Pro  Val Ser Lys Asp Asp  Ile Ala Glu 
    1055                 1060                 1065             


Phe Tyr  Asn Leu Lys Ala Lys  Ile Ala Asp Ser Lys  Ile Lys Gly 
    1070                 1075                 1080             


Glu Asn  Ile Ser Glu Lys Glu  Gln Arg Asn Ile Leu  Arg Tyr Gln 
    1085                 1090                 1095             


Arg Leu  Lys Asn Lys Val Glu  Leu Arg Asp Ile Val  Glu Tyr Gly 
    1100                 1105                 1110             


Glu Ile  Ile Asn Glu Leu Leu  Gly Gln Leu Ile Asn  Trp Ser Phe 
    1115                 1120                 1125             


Met Arg  Glu Arg Asp Leu Leu  Tyr Phe Gln Leu Gly  Phe His Tyr 
    1130                 1135                 1140             


Asn Cys  Leu Arg Asn Asn Ser  Glu Lys Pro Glu Glu  Tyr Lys Lys 
    1145                 1150                 1155             


Ile Glu  Ala Asp Asp Ile Ser  Ile Asn Asp Ala Val  Leu Tyr Gln 
    1160                 1165                 1170             


Ile Ile  Gly Met Tyr Val Asn  Gly Ile Pro Val Tyr  Thr Ser Asp 
    1175                 1180                 1185             


Asn Asn  Lys Leu Lys Gly Glu  Cys Ala Asn Gly Gly  Ala Gly Gly 
    1190                 1195                 1200             


Lys Ile  Thr Ala Phe Cys Glu  Tyr Ser Glu Tyr Leu  Gly Phe Lys 
    1205                 1210                 1215             


Lys Ala  Thr Leu Tyr Glu Ser  Gly Leu Glu Leu Phe  Glu Val Leu 
    1220                 1225                 1230             


Ala Glu  His Asp Asp Ile Ile  Lys Leu Arg Asn Gly  Ile Glu His 
    1235                 1240                 1245             


Phe Lys  Tyr Tyr Leu Gly Asn  Tyr Arg Ser Ile Met  Ser Leu Tyr 
    1250                 1255                 1260             


Ser Glu  Val Phe Asp Arg Phe  Phe Thr Tyr Asp Leu  Lys Tyr Gln 
    1265                 1270                 1275             


Lys Asn  Val Leu Asn Leu Leu  Gln Asn Ile Leu Leu  Arg His Asn 
    1280                 1285                 1290             


Ile Val  Ile Val Pro Glu Phe  Glu Ser Gly Thr Lys  Lys Val Gly 
    1295                 1300                 1305             


Lys Asn  Ile Lys Gln Ser Ala  Lys Ile Ser Ile Lys  Asn Ile Gln 
    1310                 1315                 1320             


Ser Asp  Lys Phe Thr Tyr Lys  Ile Lys Gly Gly Thr  Thr Ser Ile 
    1325                 1330                 1335             


Asp Ala  Lys Asp Asp Arg Tyr  Leu Glu Thr Ile Lys  Lys Ile Leu 
    1340                 1345                 1350             


Tyr Tyr  Pro Glu Tyr Asp Lys  Asp Ser Gly Gly Val  Cys 
    1355                 1360                 1365     


<210>  980
<211>  1432
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  980

Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser Val Thr 
1               5                   10                  15      


Glu Asn Lys Asn Glu Glu Gln Leu Ser Arg Gln Ser Leu Leu Tyr Tyr 
            20                  25                  30          


Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp Leu Glu 
        35                  40                  45              


Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr Asn Val 
    50                  55                  60                  


Ile Thr Pro Glu Ile Asp Leu Cys Lys Glu Glu Asn Arg Glu Trp Ile 
65                  70                  75                  80  


Val Glu Asp Leu Thr Lys Asn Phe Asn Ala Val Ile Asn Asn Ala Leu 
                85                  90                  95      


Arg Ser Ile Lys Asn Pro Lys Glu Lys Arg Glu Glu Arg Val Glu Lys 
            100                 105                 110         


Glu Val Ala Phe Ile Leu Asn Leu Asn Lys Asn Ser Ile Lys Ile Lys 
        115                 120                 125             


Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe Ser Ala 
    130                 135                 140                 


Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser Lys Glu 
145                 150                 155                 160 


Glu Ala Tyr Ile Arg Glu Met Ile Ser Asn Leu Val Leu Arg Lys Leu 
                165                 170                 175     


Lys Lys Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Cys Lys Met 
            180                 185                 190         


Gln Met Thr Glu Ile Thr Ile Ser Leu Met Ser Ala Ile Cys Leu Tyr 
        195                 200                 205             


Gly Asn Val Glu Ser Phe Asp Pro Val Ile Leu Lys Ala Phe Phe Glu 
    210                 215                 220                 


Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile Val 
225                 230                 235                 240 


Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys Asp 
                245                 250                 255     


Gly Lys His Leu Leu Ile Pro Ala Asn Ala Asp His Arg Lys Lys Lys 
            260                 265                 270         


Tyr Val Phe Glu Phe Met Arg Lys Tyr Ala Ala Ala Glu Glu Lys Glu 
        275                 280                 285             


Lys Arg Glu Ile Thr Glu His Ile Gln Asn Leu Ile Gly Leu Tyr Leu 
    290                 295                 300                 


Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asn Met 
305                 310                 315                 320 


Thr Glu Ser His Asn Cys Ile Ser Gly Glu Ile Glu Glu Ile Phe Asn 
                325                 330                 335     


Glu Ile Glu Glu Leu Glu Asn Ser Ser Lys Gln Lys Arg Glu Glu Lys 
            340                 345                 350         


Lys Lys Thr Arg Glu Glu Leu Asp Lys Ile Gln Glu Ser Arg Lys Gly 
        355                 360                 365             


Asn Lys Arg Asn Thr Asn Ser Asn Asn Gln Asn Tyr Lys Asn Asn Lys 
    370                 375                 380                 


Thr Asp Ser Asp Lys Lys Glu Asn Gln Ala Asp Ala Asn Glu Asn Lys 
385                 390                 395                 400 


Leu Lys Glu Asn Glu Leu Arg Asp Lys Arg Arg Arg Leu Ser Lys Glu 
                405                 410                 415     


Leu Glu Asn Leu Asp Ser Glu Val Arg Ile Lys Lys Glu Lys Leu Lys 
            420                 425                 430         


Asn Thr Thr Val Lys Glu Met Ala Leu Lys Tyr Arg Ala Ala Val Asn 
        435                 440                 445             


Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile Lys Glu 
    450                 455                 460                 


Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr Ile Asp 
465                 470                 475                 480 


Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp Arg Tyr 
                485                 490                 495     


Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu Trp Thr 
            500                 505                 510         


Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val Tyr His 
        515                 520                 525             


Phe Ala Ile Pro Asp Leu Ser Gly Ala Leu Glu Gly Glu Ser Val Ser 
    530                 535                 540                 


Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly Phe Asp 
545                 550                 555                 560 


Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met Glu Lys 
                565                 570                 575     


Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr Pro Glu 
            580                 585                 590         


Glu Glu Arg Glu Lys Pro Gly His Glu Asp Val Leu Leu Met Lys Thr 
        595                 600                 605             


Leu Ser Glu Ile Glu Glu Ser Gln Thr Glu Glu Glu Arg Gln Lys Lys 
    610                 615                 620                 


His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp Ala Asp 
625                 630                 635                 640 


Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg Lys Lys 
                645                 650                 655     


Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr Lys Glu 
            660                 665                 670         


Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His Tyr Thr 
        675                 680                 685             


Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Glu Leu Thr Glu Tyr 
    690                 695                 700                 


Phe Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg Glu Lys 
705                 710                 715                 720 


Tyr Tyr Thr Asn Asn Val Trp Lys Tyr Tyr Asp Ile Glu Val Ile Asn 
                725                 730                 735     


Asn Ile Met Gly Lys Ile Tyr Cys Gly Arg Lys Tyr Arg Ala Ala Gln 
            740                 745                 750         


Val Pro Ala Phe Asn Asn Ile Ile Ser Arg Pro Ala Leu Pro Gln Leu 
        755                 760                 765             


Met Asp Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met Asn Cys 
    770                 775                 780                 


Pro Asp Arg Asp Val Ile Lys Lys Tyr Trp Ser Ser Leu Phe Phe Val 
785                 790                 795                 800 


Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Glu Lys Pro 
                805                 810                 815     


Glu Asp Asn Ile Lys Glu Arg Phe Phe Arg Ala Met Glu Lys Glu Ser 
            820                 825                 830         


Gly Gln Ala Lys Asp Gly Lys Glu Gln Lys Ala Trp Glu Ser Phe Glu 
        835                 840                 845             


Asn Arg Ile Asp Gln Ile Gly Arg Glu Arg Ser Phe Gly Ala Ile Cys 
    850                 855                 860                 


Gln Gly Leu Met Val Glu Tyr Met Leu Gln Asn Arg Asp Ile Ser Met 
865                 870                 875                 880 


Val Gln Thr Glu Thr Gly Asp Gly Lys Thr Asn Lys Lys Gln Ile Tyr 
                885                 890                 895     


Lys His Tyr Arg Thr Leu Leu Tyr Ile Cys Ile Arg Ser Ala Phe Thr 
            900                 905                 910         


Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro Val Leu Thr 
        915                 920                 925             


Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Gln Thr Asp Gly Leu Lys 
    930                 935                 940                 


His Leu Ser Leu Phe Asp His Leu Lys Glu Thr Phe Asn Asp Ala Glu 
945                 950                 955                 960 


Ser Gly Ser Phe Trp Tyr Met Ala Ala His Phe Ile Asn Gln Lys Tyr 
                965                 970                 975     


Leu Asn His Leu Ile Gly Ser Ile Arg Asn Tyr Leu Gln Phe Thr Glu 
            980                 985                 990         


Asp Ile Glu Asp Arg Ala Leu Ser  Leu Gly Asp Cys Val  Asp Asn Lys 
        995                 1000                 1005             


Arg Glu  Glu Lys Asn Leu Arg  Tyr Arg Asn Thr Leu  Glu Ile Leu 
    1010                 1015                 1020             


Glu Phe  Val Ala Gln Phe Cys  Glu Arg Thr Thr Asn  Val Met Glu 
    1025                 1030                 1035             


Asp Tyr  Phe Glu Ser Asn Gln  Glu Tyr Ala Ala Tyr  Leu Ser Gly 
    1040                 1045                 1050             


Phe Val  Asp Tyr Asn Val Ser  Lys Lys Glu Thr Asp  Ile Glu Lys 
    1055                 1060                 1065             


Ala Leu  Tyr Gly Phe Cys Arg  Gln Lys Phe Lys Val  Asp Gly Lys 
    1070                 1075                 1080             


Glu Tyr  Met Ala Gly Ile Tyr  Tyr Asp Gly Glu Asn  Leu Ile Pro 
    1085                 1090                 1095             


Asn Arg  Asn Ile Ile Arg Ala  Asn Met Tyr Gly Asn  Val Ser Cys 
    1100                 1105                 1110             


Leu Lys  Pro Tyr Met Asp Arg  Ile Thr Leu Lys Glu  Ile Arg Thr 
    1115                 1120                 1125             


Met Tyr  Ala Asp Gln Asn Lys  Leu Asp Thr Val Leu  Lys Glu Gly 
    1130                 1135                 1140             


Val Cys  Arg Thr Glu Glu Glu  Gln Lys Ala Tyr Arg  Glu Tyr Gln 
    1145                 1150                 1155             


Asn Glu  Lys Asn Arg Ile Glu  Leu Phe Asp Leu Cys  Thr Tyr Thr 
    1160                 1165                 1170             


Gln Ile  Leu Asn Asp Ile Gln  Ala Lys Leu Ile Gly  Trp Ser Tyr 
    1175                 1180                 1185             


Met Arg  Glu Arg Asp Leu Met  Tyr Tyr Gln Leu Gly  Tyr Tyr Tyr 
    1190                 1195                 1200             


Thr Lys  Leu Phe Trp Thr Asp  Ser Ile Ser Glu Glu  Asp Ala Arg 
    1205                 1210                 1215             


Arg Arg  Leu Met Gly Glu Leu  Val Asn Val Glu Asp  Gly Val Ile 
    1220                 1225                 1230             


Leu Tyr  Gln Ile Leu Ala Phe  Asn Ser Tyr Asn Leu  Pro Ile Ile 
    1235                 1240                 1245             


Ala Asn  Lys Asn Asn Thr Val  Thr Phe Leu Lys Gly  Glu Gly Ser 
    1250                 1255                 1260             


Ile Gly  Gly Lys Ala Ile Thr  Ala Phe Leu Lys Asn  Tyr Glu Asn 
    1265                 1270                 1275             


Ala Glu  Arg Ile Tyr Glu Glu  Ala Leu Asp Leu Phe  Glu Asn Thr 
    1280                 1285                 1290             


Asp Glu  His Ala Ala Ile Ile  Asn Thr Arg Asn Tyr  Ile Glu His 
    1295                 1300                 1305             


Phe Lys  Tyr Phe Ile Lys Ser  Asp Arg Ser Met Met  Asp Leu Tyr 
    1310                 1315                 1320             


Ser Glu  Val Tyr Asp Arg Phe  Phe Arg His Asp His  Asn Arg Lys 
    1325                 1330                 1335             


Lys Asn  Val Pro Asp Ser Leu  Lys Asn Val Leu Ala  Asp Asn Phe 
    1340                 1345                 1350             


Met Ile  Ala Asp Ile Ser Met  Glu Leu Gly Ser Lys  Lys Val Gly 
    1355                 1360                 1365             


Glu Lys  Lys Lys Gly Phe Arg  Glu His Lys Ala Ala  Arg Ile Glu 
    1370                 1375                 1380             


Phe Thr  Asp Arg Gly Ile Arg  Ser Thr Asp Met Thr  Tyr Thr Val 
    1385                 1390                 1395             


Lys Pro  Asp Pro Lys Asp Ser  Lys Lys Asp Glu Lys  Val Leu Val 
    1400                 1405                 1410             


Pro Ala  Arg Ser Glu Val Phe  Leu Lys Gln Phe Gln  Lys Ile Leu 
    1415                 1420                 1425             


Glu Tyr  Arg Ile 
    1430         


<210>  981
<211>  1281
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  981

Met Lys Leu Ile Arg Arg Arg Ile Ser Gly Asn Ser Val Asp Gln Lys 
1               5                   10                  15      


Ile Thr Ala Ala Phe Tyr Arg Asp Ile Ser Gln Gly Leu Leu Tyr Tyr 
            20                  25                  30          


Asp Ser Glu Asp Asn Asp Cys Thr Asp Lys Val Ile Glu Ser Met Asp 
        35                  40                  45              


Phe Glu Arg Ser Trp Arg Gly Arg Ile Leu Lys Asn Gly Glu Asp Asp 
    50                  55                  60                  


Lys Asn Pro Phe Tyr Met Phe Val Lys Gly Leu Val Gly Ser Asn Asp 
65                  70                  75                  80  


Lys Ile Val Cys Glu Pro Ile Asp Val Asp Gly Asp Pro Asp Asn Leu 
                85                  90                  95      


Asp Ile Leu Ile Asn Lys Asn Leu Thr Gly Phe Gly Arg Asn Leu Lys 
            100                 105                 110         


Ala Pro Asp Ser Asn Asp Thr Leu Glu Asn Leu Ile Arg Lys Ile Gln 
        115                 120                 125             


Ala Gly Ile Pro Glu Glu Glu Val Leu Pro Glu Leu Lys Lys Ile Lys 
    130                 135                 140                 


Glu Met Ile Gln Lys Asp Ile Val Asn Arg Lys Glu Gln Leu Leu Lys 
145                 150                 155                 160 


Ser Ile Lys Asn Asn Arg Ile Pro Phe Ser Leu Glu Gly Ser Lys Leu 
                165                 170                 175     


Val Pro Ser Thr Lys Lys Met Lys Trp Leu Phe Lys Leu Ile Asp Val 
            180                 185                 190         


Pro Asn Lys Thr Phe Asn Glu Lys Met Leu Glu Lys Tyr Trp Glu Ile 
        195                 200                 205             


Tyr Asp Tyr Asp Lys Leu Lys Ala Asn Ile Thr Asn Arg Leu Asp Lys 
    210                 215                 220                 


Thr Asp Lys Lys Ala Arg Ser Ile Ser Arg Ala Val Ser Glu Glu Leu 
225                 230                 235                 240 


Arg Glu Tyr His Lys Asn Leu Arg Thr Asn Tyr Asn Arg Phe Val Ser 
                245                 250                 255     


Gly Asp Arg Pro Ala Ala Gly Leu Asp Asn Gly Gly Ser Ala Lys Tyr 
            260                 265                 270         


Asn Pro Asp Lys Glu Glu Phe Leu Leu Phe Leu Lys Glu Val Glu Gln 
        275                 280                 285             


Tyr Phe Lys Lys Tyr Phe Pro Val Lys Ser Lys His Ser Asn Lys Ser 
    290                 295                 300                 


Lys Asp Lys Ser Leu Val Asp Lys Tyr Lys Asn Tyr Cys Ser Tyr Lys 
305                 310                 315                 320 


Val Val Lys Lys Glu Val Asn Arg Ser Ile Ile Asn Gln Leu Val Ala 
                325                 330                 335     


Gly Leu Ile Gln Gln Gly Lys Leu Leu Tyr Tyr Phe Tyr Tyr Asn Asp 
            340                 345                 350         


Thr Trp Gln Glu Asp Phe Leu Asn Ser Tyr Gly Leu Ser Tyr Ile Gln 
        355                 360                 365             


Val Glu Glu Ala Phe Lys Lys Ser Val Met Thr Ser Leu Ser Trp Gly 
    370                 375                 380                 


Ile Asn Arg Leu Thr Ser Phe Phe Ile Asp Asp Ser Asn Thr Val Lys 
385                 390                 395                 400 


Phe Asp Asp Ile Thr Thr Lys Lys Ala Lys Glu Ala Ile Glu Ser Asn 
                405                 410                 415     


Tyr Phe Asn Lys Leu Arg Thr Cys Ser Arg Met Gln Asp His Phe Lys 
            420                 425                 430         


Glu Lys Leu Ala Phe Phe Tyr Pro Val Tyr Val Lys Asp Lys Lys Asp 
        435                 440                 445             


Arg Pro Asp Asp Asp Ile Glu Asn Leu Ile Val Leu Val Lys Asn Ala 
    450                 455                 460                 


Ile Glu Ser Val Ser Tyr Leu Arg Asn Arg Thr Phe His Phe Lys Glu 
465                 470                 475                 480 


Ser Ser Leu Leu Glu Leu Leu Lys Glu Leu Asp Asp Lys Asn Ser Gly 
                485                 490                 495     


Gln Asn Lys Ile Asp Tyr Ser Val Ala Ala Glu Phe Ile Lys Arg Asp 
            500                 505                 510         


Ile Glu Asn Leu Tyr Asp Val Phe Arg Glu Gln Ile Arg Ser Leu Gly 
        515                 520                 525             


Ile Ala Glu Tyr Tyr Lys Ala Asp Met Ile Ser Asp Cys Phe Lys Thr 
    530                 535                 540                 


Cys Gly Leu Glu Phe Ala Leu Tyr Ser Pro Lys Asn Ser Leu Met Pro 
545                 550                 555                 560 


Ala Phe Lys Asn Val Tyr Lys Arg Gly Ala Asn Leu Asn Lys Ala Tyr 
                565                 570                 575     


Ile Arg Asp Lys Gly Pro Lys Glu Thr Gly Asp Gln Gly Gln Asn Ser 
            580                 585                 590         


Tyr Lys Ala Leu Glu Glu Tyr Arg Glu Leu Thr Trp Tyr Ile Glu Val 
        595                 600                 605             


Lys Asn Asn Asp Gln Ser Tyr Asn Ala Tyr Lys Asn Leu Leu Gln Leu 
    610                 615                 620                 


Ile Tyr Tyr His Ala Phe Leu Pro Glu Val Arg Glu Asn Glu Ala Leu 
625                 630                 635                 640 


Ile Thr Asp Phe Ile Asn Arg Thr Lys Glu Trp Asn Arg Lys Glu Thr 
                645                 650                 655     


Glu Glu Arg Leu Asn Thr Lys Asn Asn Lys Lys His Lys Asn Phe Asp 
            660                 665                 670         


Glu Asn Asp Asp Ile Thr Val Asn Thr Tyr Arg Tyr Glu Ser Ile Pro 
        675                 680                 685             


Asp Tyr Gln Gly Glu Ser Leu Asp Asp Tyr Leu Lys Val Leu Gln Arg 
    690                 695                 700                 


Lys Gln Met Ala Arg Ala Lys Glu Val Asn Glu Lys Glu Glu Gly Asn 
705                 710                 715                 720 


Asn Asn Tyr Ile Gln Phe Ile Arg Asp Val Val Val Trp Ala Phe Gly 
                725                 730                 735     


Ala Tyr Leu Glu Asn Lys Leu Lys Asn Tyr Lys Asn Glu Leu Gln Pro 
            740                 745                 750         


Pro Leu Ser Lys Glu Asn Ile Gly Leu Asn Asp Thr Leu Lys Glu Leu 
        755                 760                 765             


Phe Pro Glu Glu Lys Val Lys Ser Pro Phe Asn Ile Lys Cys Arg Phe 
    770                 775                 780                 


Ser Ile Ser Thr Phe Ile Asp Asn Lys Gly Lys Ser Thr Asp Asn Thr 
785                 790                 795                 800 


Ser Ala Glu Ala Val Lys Thr Asp Gly Lys Glu Asp Glu Lys Asp Lys 
                805                 810                 815     


Lys Asn Ile Lys Arg Lys Asp Leu Leu Cys Phe Tyr Leu Phe Leu Arg 
            820                 825                 830         


Leu Leu Asp Glu Asn Glu Ile Cys Lys Leu Gln His Gln Phe Ile Lys 
        835                 840                 845             


Tyr Arg Cys Ser Leu Lys Glu Arg Arg Phe Pro Gly Asn Arg Thr Glu 
    850                 855                 860                 


Leu Glu Lys Glu Thr Glu Leu Leu Ala Glu Leu Glu Glu Leu Met Glu 
865                 870                 875                 880 


Leu Val Arg Phe Thr Met Pro Ser Ile Pro Glu Ile Ser Ala Lys Ala 
                885                 890                 895     


Glu Ser Gly Tyr Asp Thr Met Ile Lys Lys Tyr Phe Lys Asp Phe Ile 
            900                 905                 910         


Glu Lys Lys Val Phe Lys Asn Pro Lys Thr Ser Asn Leu Tyr Tyr His 
        915                 920                 925             


Ser Asp Ser Lys Thr Pro Val Thr Arg Lys Tyr Met Ala Leu Leu Met 
    930                 935                 940                 


Arg Ser Ala Pro Leu His Leu Tyr Lys Asp Ile Phe Lys Gly Tyr Tyr 
945                 950                 955                 960 


Leu Ile Thr Lys Lys Glu Cys Leu Glu Tyr Ile Lys Leu Ser Asn Ile 
                965                 970                 975     


Ile Lys Asp Tyr Gln Asn Ser Leu Asn Glu Leu His Glu Gln Leu Glu 
            980                 985                 990         


Arg Ile Lys Leu Lys Ser Glu Lys  Gln Asn Gly Lys Asp  Ser Leu Tyr 
        995                 1000                 1005             


Leu Asp  Lys Lys Asp Phe Tyr  Lys Val Lys Glu Tyr  Val Glu Asn 
    1010                 1015                 1020             


Leu Glu  Gln Val Ala Arg Tyr  Lys His Leu Gln His  Lys Ile Asn 
    1025                 1030                 1035             


Phe Glu  Ser Leu Tyr Arg Ile  Phe Arg Ile His Val  Asp Ile Ala 
    1040                 1045                 1050             


Ala Arg  Met Val Gly Tyr Thr  Gln Asp Trp Glu Arg  Asp Met His 
    1055                 1060                 1065             


Phe Leu  Phe Lys Ala Leu Val  Tyr Asn Gly Val Leu  Glu Glu Arg 
    1070                 1075                 1080             


Lys Phe  Glu Ala Ile Phe Asn  Asn Asn Asp Gly Arg  Ile Val Lys 
    1085                 1090                 1095             


Lys Ile  Gln Asn Asn Leu Asn  Asn Lys Asn Arg Glu  Leu Val Ser 
    1100                 1105                 1110             


Met Leu  Cys Trp Asn Lys Lys  Leu Asn Lys Asn Glu  Phe Gly Ala 
    1115                 1120                 1125             


Ile Ile  Trp Lys Arg Asn Pro  Ile Ala His Leu Asn  His Phe Thr 
    1130                 1135                 1140             


Gln Thr  Glu Gln Asn Ser Lys  Ser Ser Leu Glu Ser  Leu Ile Asn 
    1145                 1150                 1155             


Ser Leu  Arg Ile Leu Leu Ala  Tyr Asp Arg Lys Arg  Gln Asn Ala 
    1160                 1165                 1170             


Val Thr  Lys Thr Ile Asn Asp  Leu Leu Leu Asn Asp  Tyr His Ile 
    1175                 1180                 1185             


Arg Ile  Lys Trp Glu Gly Arg  Val Asp Glu Gly Gln  Ile Tyr Phe 
    1190                 1195                 1200             


Asn Ile  Lys Glu Lys Glu Asp  Ile Glu Asn Glu Pro  Ile Ile His 
    1205                 1210                 1215             


Leu Lys  His Leu His Lys Lys  Asp Cys Tyr Ile Tyr  Lys Asn Ser 
    1220                 1225                 1230             


Tyr Met  Phe Asp Lys Gln Lys  Glu Trp Ile Cys Asn  Gly Ile Lys 
    1235                 1240                 1245             


Glu Glu  Val Tyr Asp Lys Ser  Ile Leu Lys Cys Ile  Gly Asn Leu 
    1250                 1255                 1260             


Phe Lys  Phe Asp Tyr Glu Asp  Lys Asn Lys Ser Ser  Ala Asn Pro 
    1265                 1270                 1275             


Lys His  Thr 
    1280     


<210>  982
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  982

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Ser Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Lys Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Lys Lys Asp Glu Lys Phe Asn Asp Lys Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Val Lys Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Glu 
    1100                 1105                 1110             


Ile Gln  Ser Leu Lys Ser Glu  Glu Ile Val His Leu  Lys Lys Leu 
    1115                 1120                 1125             


Lys Leu  Lys Asp Asn Asp Lys  Lys Lys Glu Pro Ile  Lys Thr Tyr 
    1130                 1135                 1140             


Arg Asn  Ser Lys Glu Leu Cys  Lys Leu Val Lys Val  Met Phe Glu 
    1145                 1150                 1155             


Tyr Lys  Met Glu Glu Lys Ser  Ser Glu Lys 
    1160                 1165             


<210>  983
<211>  1264
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  983

Met Lys Val Ser Lys Val Asn His Arg Arg Ala Ala Val Ala Val Asn 
1               5                   10                  15      


Lys Lys Ser Val Thr Val Asn Gly Ile Leu Tyr Asp Ala Pro Val Lys 
            20                  25                  30          


Lys Asn Val Lys Thr Gly Asn Met Ser Ala Tyr Val Ser Ser Lys Tyr 
        35                  40                  45              


Val Ile Asp Asn Val Val Lys Asn Ser Ser Arg Leu Tyr Ser Pro Phe 
    50                  55                  60                  


Ser Ser Lys Arg Ile Val Ile Asp Arg Glu Lys Ile Arg Ile Ala Asp 
65                  70                  75                  80  


Arg Leu Lys Gln Cys Tyr Val Asn Phe Val Lys Tyr Tyr Leu Ser Asn 
                85                  90                  95      


Gly Ser Leu Asn Glu Gln Gln Met Arg Phe Asn Pro Asn Asn Thr Tyr 
            100                 105                 110         


Met Ala Asp Ser Arg Val His Phe Cys Val Pro Ser Gly Ile Asp Ile 
        115                 120                 125             


Glu Ser Leu Ile Asn Ser Ile Val Asp Ser Ser Leu Arg Lys Ser Leu 
    130                 135                 140                 


Lys Arg Thr Tyr Arg Phe Glu Thr Asn Tyr Gly Glu Lys Asn Thr Phe 
145                 150                 155                 160 


Asn Leu Pro Asp Leu Val Lys Lys Ser Ile Lys Ile Tyr Cys Thr Asp 
                165                 170                 175     


Glu Lys Arg Lys Leu Asn Asp Arg Glu Glu Gln Glu Met Tyr Val Leu 
            180                 185                 190         


Phe Ser Tyr Met Tyr Glu Asp Lys Tyr Lys Asp Arg Gln Lys Val Leu 
        195                 200                 205             


Ile Ala Asn Ser Ile Ser Asn Gln Ala Thr Lys Val Lys Val Cys Asp 
    210                 215                 220                 


Asp Glu Ser Arg Leu Ile Lys Leu Ser Ile Ala Asp Thr Lys Lys Lys 
225                 230                 235                 240 


Pro Leu Trp Asp Phe Ile Val Asp Tyr Ala Asn Ser Asp Lys Asn Gly 
                245                 250                 255     


Gln Tyr Thr Ile Leu Arg Asn Ile Arg Lys Ser Ile Val Leu Phe Val 
            260                 265                 270         


Cys Gly Val Asp Val Tyr Arg Asn Ile Glu Asn Asn Asp Asn Leu Asp 
        275                 280                 285             


Ile Trp Lys Trp Glu Glu Tyr Gly Ile Gln Glu Ser Gln Leu Phe Val 
    290                 295                 300                 


Lys Ile Glu Asn Cys Tyr Thr Thr Lys Gly Glu Asp Ile Ala Leu Asn 
305                 310                 315                 320 


Glu Ile Arg Asn Val Asn Leu Asp His Tyr Met Lys Ala Ile Gly Val 
                325                 330                 335     


Leu Asp Asp Glu Arg Ser Lys Phe Trp Phe Gln His Tyr Glu Asn Thr 
            340                 345                 350         


Ile Glu Ala Leu Phe Ser Lys Lys Ser Lys Arg Lys Ile Glu Arg Ile 
        355                 360                 365             


Lys Thr Ala Tyr Leu Cys Glu Tyr Leu Trp Lys Asn Phe Cys Ser Tyr 
    370                 375                 380                 


Val Ala Leu Lys Tyr Val Asp Leu Gly Lys Gly Val Tyr His Phe Thr 
385                 390                 395                 400 


Met Ser Asp Lys Leu Ser Leu Met Asn Lys Asn Thr Asn Glu Asn Gly 
                405                 410                 415     


Ile Lys Phe Gly Glu Val Asp Ser Arg Phe Asn Lys Gly Ile Ser Ser 
            420                 425                 430         


Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Thr Ile Asp Arg Asn Ile 
        435                 440                 445             


Ser Thr Tyr Thr Thr Phe Ala Thr Asn Ile Phe Ala Lys Ser Val Ile 
    450                 455                 460                 


Lys Asp Ser Tyr Arg Gln Lys Lys Ala Gly Asn Ser Asp Ala Leu Gln 
465                 470                 475                 480 


Tyr Asp Asp Glu Thr Tyr Tyr Asn Arg Lys Ala Met Asn Pro Tyr Ala 
                485                 490                 495     


Leu Lys Arg Val Leu Arg Tyr Trp Gly Gly Gln Ser Arg Trp Lys Ser 
            500                 505                 510         


Glu Leu Glu Glu Leu Asn Val Ala Glu Leu Cys Ile Asp Ile Lys Asn 
        515                 520                 525             


Arg Leu Ser Lys Ile Arg Asn Ser Gly Val His Tyr Thr Ser Thr Ser 
    530                 535                 540                 


Ala Leu Lys Gly Asn Asp Asp Asp Ser Ile Val Gly Met Leu Ile Lys 
545                 550                 555                 560 


Lys Asp Phe Asp Asp Ile Lys Asp Val Tyr Ala Ser Lys Tyr Tyr Ser 
                565                 570                 575     


Asn Asn Val Trp Met Phe Tyr Asn Thr Asp Lys Ile Ser Lys Met Met 
            580                 585                 590         


Glu Tyr Leu Tyr Gln Asp Asp Ser Asn Ile Arg Asp Ala Gln Ile Pro 
        595                 600                 605             


Ala Phe Asn Ser Val Ile Lys Arg Lys Asp Met Ala Glu Val Ile Glu 
    610                 615                 620                 


Lys Ile Val Lys Lys Asn Ser Tyr Lys Thr Ile Lys Glu Pro Tyr Gln 
625                 630                 635                 640 


Arg Glu Lys Tyr Arg Ser Cys Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
                645                 650                 655     


Tyr Asn Arg Phe Ile Lys Gln Asp Asn Leu Lys Asp Gln Val Ile Gln 
            660                 665                 670         


Ile Ile Asp Ser Asn Thr Glu Leu Ile Gly Asp Asn Ser Arg Ala Val 
        675                 680                 685             


Asp Asn Leu Lys Lys Arg Ile His Asp Val Asp Ser Gln Thr Met Ser 
    690                 695                 700                 


Phe Gly Glu Leu Cys Gln Val Ile Met Thr Asp Tyr Asn Met Gln Asn 
705                 710                 715                 720 


Gln Glu Asn Lys Ser Ile Lys Ser Lys Glu Arg Gln Asp Lys Asp Arg 
                725                 730                 735     


Lys Asn Gly Ile Asp Asn Ser Tyr Lys His Phe Pro Leu Leu Leu His 
            740                 745                 750         


His Leu Ile Lys Val Ser Phe Leu Lys Phe Ile Lys Thr Asp Glu Lys 
        755                 760                 765             


Leu Ala Phe Ile Arg Glu Pro Arg Ile Thr Glu Trp Asp Lys Thr Leu 
    770                 775                 780                 


Glu Gln Phe Glu Ala Gln Ile Gln Thr Val Asp Ile Tyr Asn Ser Leu 
785                 790                 795                 800 


Lys Met Met Val Ala Glu Asn Lys Ser Leu Leu Asp Trp Tyr Thr Leu 
                805                 810                 815     


Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asp Val 
            820                 825                 830         


Lys Asn Tyr Ile Gln Tyr Leu Ser Asn Ile Asp Lys Arg Ala Gly Ser 
        835                 840                 845             


Val Lys Asn Asn Lys Ser Ala Ser Thr Glu Val Lys Ile Arg Gln Tyr 
    850                 855                 860                 


Ser Glu Ile Val Arg Ile Leu Asp Phe Ser Leu Gln Tyr Ile Gly Arg 
865                 870                 875                 880 


Val Ser Asn Asp Val Thr Asp Tyr Phe Val Asp Glu Asp Glu Tyr Ala 
                885                 890                 895     


Ala Phe Leu Ser Lys Tyr Val Glu Phe Ser Gly Asn Asp Ile Val Ser 
            900                 905                 910         


Met Lys Ala Phe Cys Gln Ser Arg Thr Ala Asn Gly Lys His Thr Ile 
        915                 920                 925             


Gly Leu Tyr Cys Asp Gly Ala Asn Pro Ile Met Asn Arg Asn Ile Ala 
    930                 935                 940                 


Tyr Ala Lys Met Tyr Gly Asn Asp Glu Ile Leu Ser Tyr Ile Tyr Asn 
945                 950                 955                 960 


Lys Val Thr Lys Lys Asp Ile Glu Lys Tyr Tyr Val Ser Gln Asp Asn 
                965                 970                 975     


Leu Glu Lys Val Phe Ala Asp Gly Lys Cys Gln Asp Val Gln Gln Gln 
            980                 985                 990         


Asn Ala Leu Cys Asp Phe Gln Lys  Met Lys Asn His Ile  Glu Leu Thr 
        995                 1000                 1005             


Glu Val  Ser Ile Tyr Thr Asp  Ile Leu Asn Asp Phe  Met Ala Gln 
    1010                 1015                 1020             


Phe Ile  Ser Trp Ala Tyr Leu  Arg Glu Arg Asp Leu  Met Tyr Phe 
    1025                 1030                 1035             


Gln Leu  Gly Leu Asn Tyr Ile  Arg Met Phe Tyr Gly  Thr Tyr Glu 
    1040                 1045                 1050             


Leu Glu  Glu Lys Tyr Tyr Lys  Leu His Gly Glu Asn  Ile Asn Ile 
    1055                 1060                 1065             


Glu Lys  Gly Ala Leu Leu Tyr  Gln Ile Val Ala Met  Tyr Ser His 
    1070                 1075                 1080             


Glu Leu  Pro Ile Tyr Lys Val  Asp Glu Ser Gly Ile  Ala Ile Leu 
    1085                 1090                 1095             


Ala Glu  Lys Gln Gly Ser Ser  Gly Ala Ser Ile Lys  Ser Phe Val 
    1100                 1105                 1110             


Thr Glu  Tyr Cys Lys Glu Glu  Met Lys Lys Ala Tyr  Thr Tyr Glu 
    1115                 1120                 1125             


Asn Gly  Leu Glu Leu Phe Glu  Asp Val Asn Gln His  Asp Asp Arg 
    1130                 1135                 1140             


Asn Asp  Phe Ala His Met Arg  Tyr Met Ser Ala Arg  Asp Lys Ser 
    1145                 1150                 1155             


Ile Met  Asp Ile Val Ser Glu  Ile Tyr Asn Gly Phe  Phe Ile Tyr 
    1160                 1165                 1170             


Asp Thr  Lys Leu Lys Lys Ser  Val Ser Phe Ile Phe  Lys Asn Ile 
    1175                 1180                 1185             


Leu Met  Arg Tyr Ala Val Asp  Val Asn Ile Glu Phe  Cys His Lys 
    1190                 1195                 1200             


Gly Asp  Asn Glu Asp Thr Asn  Asn Leu Ile Arg Ile  Lys Asp Glu 
    1205                 1210                 1215             


Val Gly  Leu Tyr Ser Asp Lys  Tyr Thr Tyr Lys Val  Glu Asp Asn 
    1220                 1225                 1230             


Asp Thr  Val Asp Ile Glu Val  Arg Asn Ser Glu Phe  Leu Glu Gln 
    1235                 1240                 1245             


Leu Lys  Lys Leu Leu Glu Tyr  Lys Lys Glu Ser Glu  Gly Ser Glu 
    1250                 1255                 1260             


Leu 
    


<210>  984
<211>  1426
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  984

Met Gly Glu Phe Ser Leu Lys Gln Lys Asn Thr Arg Val Arg Ile Asp 
1               5                   10                  15      


Arg Val Gly Arg Lys Arg His Met Asp Phe Gly Thr Ser Arg Thr Cys 
            20                  25                  30          


Cys Ile Phe Gly Asp Ala Arg Arg Val Lys Lys Tyr Thr Arg Ala Glu 
        35                  40                  45              


Glu Ser Arg Met Lys Ile Ser Lys Glu Asn His Lys Arg Thr Ala Val 
    50                  55                  60                  


Ala Val Lys Glu Asn Arg Val Gly Gly Val Val Tyr Lys Val Pro Gly 
65                  70                  75                  80  


Ser Ser Glu Ile Asp Leu Asn Lys Tyr Leu Ala Lys Arg Ser Val Asp 
                85                  90                  95      


Thr Lys Ile Leu Tyr Asn Ile Phe Asn Gln Ile Gln Ala Gly Thr Ala 
            100                 105                 110         


Pro Ser Glu Tyr Glu Trp Lys Asp Tyr Leu Ser Glu Thr Glu Asn Lys 
        115                 120                 125             


Lys Arg Glu Ala Gln Lys Thr Ile Gln Lys Lys Asn Tyr Glu Leu Arg 
    130                 135                 140                 


Ser Ala Cys Gly Asp Tyr Ala Lys Lys Ala Asn Phe Val Ile Gly Lys 
145                 150                 155                 160 


Ile Ile Phe Ser Glu Lys Pro Lys Arg Ile Leu Ser Asp Glu Gln Ile 
                165                 170                 175     


Ile Phe Asn Met Lys Val Gln Arg Leu Ser Lys Phe Lys Gly Arg Leu 
            180                 185                 190         


Glu Asp Phe Val Leu Leu Thr Leu Arg Lys Ser Leu Ile Val Ser Thr 
        195                 200                 205             


Tyr Asn Glu Glu Val Phe Asp Ser Arg Asn Ala Thr Thr Val Phe Leu 
    210                 215                 220                 


Lys Asn Ile Gly Lys Glu Asn Ile Ser Ala Asp Asp Glu Arg Gln Ile 
225                 230                 235                 240 


Lys Gln Leu Leu Ala Leu Ile Arg Glu Asp Tyr Asn Lys Trp Asn Leu 
                245                 250                 255     


Asp Glu Gln Ser Ser Asp Lys Met Tyr Ser Asp Lys Lys Glu Ser Lys 
            260                 265                 270         


Gly Thr Ile Val Ile Arg Ser Ile Glu Tyr Gln Asn Met Val Ile Gln 
        275                 280                 285             


Pro Lys Glu Asp Arg Leu Cys Leu Ser Glu Ile Ser Asn Val Gly Lys 
    290                 295                 300                 


Asn Thr Lys Thr Lys Gln Thr Glu Lys Ala Gly Leu Glu Ala Phe Leu 
305                 310                 315                 320 


Thr Glu Tyr Ala Gln Ile Asp Ala Asn Ser Arg Met Glu Tyr Leu Lys 
                325                 330                 335     


Lys Leu Arg Arg Leu Leu Asp Thr Tyr Phe Ala Ala Pro Phe Ser Tyr 
            340                 345                 350         


Ile Lys Gly Ala Glu Val Ser Leu Pro Glu Asn Ile Asn Phe Ser Ser 
        355                 360                 365             


Glu Leu Lys Val Trp Glu Arg His Ala Ala Ala Lys Lys Val Asn Ile 
    370                 375                 380                 


Tyr Phe Val Glu Ile Pro Glu Ala Leu Leu Lys Ala Glu Gln Asn Asn 
385                 390                 395                 400 


Asn Met Ile Asp Lys Val Glu Lys Glu His Ser Leu Glu Gln Leu Arg 
                405                 410                 415     


Thr Asp Ile Arg Cys Arg Asn Ile Val Cys Tyr His Phe Ala Asn Ala 
            420                 425                 430         


Val Ala Ala Asp Glu Arg Tyr His Thr Leu Phe Phe Glu Asn Met Ser 
        435                 440                 445             


Met Asn Gln Tyr Trp Ile His His Met Glu Asn Ala Val Glu Arg Ile 
    450                 455                 460                 


Leu Lys Lys Cys Asn Val Gly Thr Leu Phe Lys Leu Gln Ile Gly Tyr 
465                 470                 475                 480 


Leu Ser Glu Lys Val Trp Lys Asp Leu Leu Asn Leu Leu Ser Ile Lys 
                485                 490                 495     


Tyr Ile Ala Leu Gly Lys Ala Val Tyr His Phe Ala Leu Asp Asp Ile 
            500                 505                 510         


Trp Asn Asp Val Ser Asp Lys Lys Leu Gly Lys Ile Asn Ala Asn Thr 
        515                 520                 525             


Leu Lys Gly Ile Ser Ser Phe Asp Tyr Glu Met Leu Lys Ala Gln Glu 
    530                 535                 540                 


Asp Leu Gln Arg Glu Met Ala Val Gly Val Ala Phe Ser Thr Asn Asn 
545                 550                 555                 560 


Leu Ser Arg Ala Thr Cys Gln Met Asn Asn Leu Ala Asp Arg Glu Ser 
                565                 570                 575     


Asp Phe Leu Leu Trp Asp Glu Lys Val Ile Ala Lys His Ile Lys Ser 
            580                 585                 590         


Thr Glu Lys Gly Glu Ile Leu Ser Ala Ile Leu Gln Phe Phe Gly Gly 
        595                 600                 605             


Arg Ser Ser Trp Asp Glu Ser Leu Phe Glu Asn Ala Tyr Ser Asp Phe 
    610                 615                 620                 


Asn Tyr Glu Leu Gln Phe Leu Asn Asp Leu Lys Arg Ala Ile Tyr Ala 
625                 630                 635                 640 


Ala Arg Asn Glu Thr Phe His Phe Lys Thr Ala Ala Ile Asp Glu Gly 
                645                 650                 655     


Ser Trp Asn Thr Arg Leu Phe Gly Asn Met Phe Glu Lys Glu Ala Gly 
            660                 665                 670         


Ile Cys Leu Asp Val Glu Lys Asn Lys Phe Tyr Ser Asn Asn Leu Ala 
        675                 680                 685             


Leu Phe Tyr Thr Gln Lys Asp Leu Arg Val Ile Leu Asp Glu Leu Tyr 
    690                 695                 700                 


Gly Lys Glu Cys Phe Arg Ala Ala Gln Ile Pro Ser Tyr Asn Thr Ile 
705                 710                 715                 720 


Leu Pro Arg Lys Ser Phe Pro Asp Phe Leu Lys Gln Leu Leu Lys Leu 
                725                 730                 735     


His Glu Pro Ala Tyr Asp Leu Ala Ile Arg Asp Gln Trp Tyr Ser Ala 
            740                 745                 750         


Cys Tyr Tyr Leu Phe Lys Glu Val Tyr Tyr Asn Leu Phe Leu Gln Ser 
        755                 760                 765             


Ser Ser Ala Lys Glu Leu Phe Glu Asp Ala Val Lys Glu Leu Arg Gly 
    770                 775                 780                 


Ala Asp Glu Lys Gln Lys Arg Ala Val Glu Asn Phe Lys Lys Arg Tyr 
785                 790                 795                 800 


Arg Glu Ile Ser Ile Ser Ala Ser Leu Ala Asp Ile Cys Gln Ser Phe 
                805                 810                 815     


Met Thr Glu Tyr Asn Gln Gln Asn Asn Lys Asp Arg Lys Val Arg Ser 
            820                 825                 830         


Ala Asn Asp Gly Met Phe Asn Glu Pro Ile Tyr Gln His Tyr Arg Met 
        835                 840                 845             


Leu Leu Arg Glu Ala Leu Lys Val Ala Phe Ala Ser Tyr Ile Lys Asn 
    850                 855                 860                 


Asn Lys Glu Leu Glu Phe Val Phe Asn Pro Thr Lys Asn Leu Phe Asn 
865                 870                 875                 880 


Val Thr Ser Asp Ser Phe Leu Pro Asn Trp Ser Ser Gly Lys Tyr Asp 
                885                 890                 895     


Ser Leu Ile Ser Glu Val Lys Asn Ser Pro Glu Leu Gln Lys Trp Tyr 
            900                 905                 910         


Ile Val Gly Lys Phe Met Asn Ala Arg Met Leu Asn Leu Thr Ile Gly 
        915                 920                 925             


Ser Met Arg Ser Tyr Cys Gln Tyr Val Asn Asp Ile Gln Lys Arg Ala 
    930                 935                 940                 


Ala Ser Leu Gly Gly Arg Gln Leu His Leu Phe Val Gly Asn Val Glu 
945                 950                 955                 960 


Gln Val Lys Lys Trp Ile Gln Val Leu Glu Cys Cys Leu Leu Leu Ser 
                965                 970                 975     


Val Arg Ile Ser Asn Glu Phe Lys Asp Tyr Phe Lys Asp Glu Asp Ala 
            980                 985                 990         


Tyr Ala Ser Tyr Leu Lys Gly Tyr  Val Asp Phe Lys Asp  Ser Ile Met 
        995                 1000                 1005             


Pro Ser  Asp Tyr Ser Ala Leu  Leu Ala Phe Ser Asp  Glu Gly Lys 
    1010                 1015                 1020             


Ile Asp  Leu Tyr Val Asp Ala  Ser Asn Pro Lys Val  Asn Arg Asn 
    1025                 1030                 1035             


Ile Ile  Gln Ser Lys Leu Tyr  Ala Pro Asp Leu Val  Leu Lys Lys 
    1040                 1045                 1050             


Val Val  Lys Lys Ile Ser Lys  Asp Glu Cys Arg Glu  Phe Asn Val 
    1055                 1060                 1065             


Lys Lys  Glu Gln Ile Leu Gln  Ile Lys Asn Lys Gly  Asp Glu Val 
    1070                 1075                 1080             


Ser Trp  Glu Glu Gln Gln Arg  Ile Leu Glu Tyr Gln  Lys Leu Lys 
    1085                 1090                 1095             


Asn Arg  Val Glu Leu Arg Asp  Leu Ser Glu Tyr Gly  Glu Leu Ile 
    1100                 1105                 1110             


Asn Glu  Leu Leu Gly Gln Leu  Ile Asn Trp Ser Tyr  Leu Arg Glu 
    1115                 1120                 1125             


Arg Asp  Leu Leu Tyr Phe Gln  Leu Gly Phe His Tyr  Ser Cys Leu 
    1130                 1135                 1140             


Met Asn  Lys Ser Lys Lys Pro  Asp Ala Tyr Lys Thr  Ile Cys Ile 
    1145                 1150                 1155             


Asp Asp  Thr Ala Ser Ile Glu  Asn Ala Val Leu Tyr  Gln Ile Ile 
    1160                 1165                 1170             


Ala Met  Tyr Ile Asn Gly Phe  Pro Val Tyr Val Pro  Glu Lys Gly 
    1175                 1180                 1185             


Lys Leu  Lys Ala Gln Cys Lys  Ala Gly Ser Val Gly  Gln Lys Val 
    1190                 1195                 1200             


Gly Ala  Phe Cys Arg Trp Ala  Ser Arg Val Glu Glu  Asn Glu Tyr 
    1205                 1210                 1215             


Glu Leu  Tyr Asn Ala Gly Leu  Glu Leu Phe Glu Val  Val Lys Glu 
    1220                 1225                 1230             


His Ser  Asn Val Ile Asp Leu  Arg Asn Lys Phe Asp  His Phe Lys 
    1235                 1240                 1245             


Tyr Tyr  Gln Gly Asn Asp Ser  Ile Leu Ser Leu Tyr  Gly Glu Ile 
    1250                 1255                 1260             


Phe Asp  Arg Phe Phe Thr Tyr  Asp Met Lys Tyr Arg  Lys Asn Val 
    1265                 1270                 1275             


Leu Asn  His Leu Gln Asn Ile  Leu Leu Arg His Asn  Val Val Ile 
    1280                 1285                 1290             


Lys Pro  Val Ile Ser Lys Asp  Lys Lys Glu Val Gly  Lys Gly Glu 
    1295                 1300                 1305             


Thr Lys  Asp Gly Ala Ser Phe  Leu Leu Glu Glu Val  Ser Ser Asp 
    1310                 1315                 1320             


Arg Phe  Thr Tyr Lys Val Lys  Asp Gly Glu Arg Lys  Leu Asp Val 
    1325                 1330                 1335             


Lys Asn  Arg Leu Tyr Leu Glu  Thr Val Arg Asp Ile  Leu Tyr Phe 
    1340                 1345                 1350             


Pro Asn  Lys Ala Val Asn Asp  Lys Gly Glu Asp Val  Val Val Arg 
    1355                 1360                 1365             


Ser Gln  Lys Ala Gln Asp Ser  Asn Glu Lys Lys Val  Asp Arg Asp 
    1370                 1375                 1380             


Lys Asn  His Asp Lys Ile Lys  Asn Gly Asn Trp Lys  Lys Gly Gly 
    1385                 1390                 1395             


Asn Asn  Gln Arg Arg Lys Pro  Lys Ser Glu Glu Ala  Tyr Ser Asp 
    1400                 1405                 1410             


Arg Ile  Thr Trp Asn Pro Phe  Ala Gly Ile Lys Leu  Asp 
    1415                 1420                 1425     


<210>  985
<211>  1200
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  985

Met Asp Ala Asp Gly Leu Ser Ile Gly Pro Phe Ala Glu Ser His Asp 
1               5                   10                  15      


Ser Leu Val Ile Gly Gln Trp Ile Ser Thr Ile Asp Lys Ile Ala Thr 
            20                  25                  30          


Lys Pro Lys Gly Lys Gly Lys Ala Thr Gln Glu Gln Arg Asn Val Arg 
        35                  40                  45              


Ser Ala Leu Gly Ala Ala Cys Trp Ala Arg Leu Val His Pro Asp Gly 
    50                  55                  60                  


Thr Phe Gly Ala Leu Asp Ser Glu Arg Met Asn Trp Ala Arg Asn Thr 
65                  70                  75                  80  


Trp Glu Arg Arg Leu His Pro Tyr Ser Asp Lys Asn Phe Val Thr Asn 
                85                  90                  95      


Gly Arg Glu Lys Thr Pro Asp Ser Lys Ala His Trp Phe Asn Arg Phe 
            100                 105                 110         


Cys Lys Gly Leu Ser Val Gln Glu Val Thr Asp Pro Ser Val Ala Gly 
        115                 120                 125             


Asp Val Ala Gln Ser Ile Glu Glu His Leu Thr Lys Asp Ala Phe Arg 
    130                 135                 140                 


Arg Gly Gly Gly Thr Arg Arg Ser Pro Lys Ala Ser Ala Ser Arg Ala 
145                 150                 155                 160 


Gly Leu Ile Ala Val Arg Ala Asp Ser Ile Thr Lys Asn Ala Leu Arg 
                165                 170                 175     


Phe Pro Gly Ala Asp Ile Ala Glu Gln Arg Glu His Gly Trp Thr Glu 
            180                 185                 190         


Glu Asp Ile Ala Arg Tyr Val Ala Lys Ser Asp Pro Val Ala Gln Ile 
        195                 200                 205             


Tyr Lys Ala Val Leu Asp Ala Glu Pro Asp Gly Gln Arg Val Arg Trp 
    210                 215                 220                 


Ser Ile Ala Ala Glu Arg Leu Tyr Ala His Tyr Ala Arg Val Phe Thr 
225                 230                 235                 240 


Ala Pro Asp Ile Val Leu Asp Arg Lys Asp Ala Asp Lys Ile Leu Arg 
                245                 250                 255     


Gly Val Leu Ala Leu His Glu Ala Leu Arg Gln Leu Tyr Arg His Arg 
            260                 265                 270         


Leu Lys Arg His Arg Arg Lys Pro Val His Val Thr Val Leu Leu Pro 
        275                 280                 285             


Arg Asp Ile Arg Asp Ala Leu Thr Met Ile Ser Arg Gln Gln Asp Asn 
    290                 295                 300                 


Ser Asp Leu Asn Ala Leu Val Arg Leu Gly Lys Val Ile His His Glu 
305                 310                 315                 320 


Ala Ala Asp Gln Ala Gly Val Glu Ser Val Ala Lys Ile Ile Gly Asn 
                325                 330                 335     


Trp Pro Glu Asp Val Ser Arg Ser Tyr Tyr Trp Thr Ser Asp Gly Gln 
            340                 345                 350         


Thr Glu Ile Lys Arg Thr Glu Ala Phe Val Arg Ala Trp Arg Gly Pro 
        355                 360                 365             


Ile Ala His Ala Gln Arg Thr Leu Ala Asp Trp Val Asp Pro Asp Arg 
    370                 375                 380                 


Leu Ser Val Lys Ser Asp Ser Ala Glu Ala Lys Pro Pro Asp Met Leu 
385                 390                 395                 400 


Gly Ala Lys Phe Asp Asp Ala Leu Ala Gln Leu Asp Asp Asp Ala Ala 
                405                 410                 415     


Ile Thr Lys Ala Arg Leu Leu Phe Gly Thr Arg Ser Asp Ala Leu Gly 
            420                 425                 430         


Gly Pro Asp Pro Lys Ala Val Leu Arg Leu Thr Lys Arg Ala Leu Ser 
        435                 440                 445             


Lys Leu Arg Asn Ala Ala Phe His Phe Lys Gly Met Gly Gly Phe Val 
    450                 455                 460                 


Gln Asp Met Thr Leu Lys Ile Leu Pro Ser Gly Ser Glu Asp Cys Glu 
465                 470                 475                 480 


Val Leu Glu Arg Val His Ala Leu Trp His Ala Asp Gln Lys Asp Arg 
                485                 490                 495     


Met Ile Arg Val Lys Asp Ala Leu Val Gly Ala His Ala Glu Val Tyr 
            500                 505                 510         


Leu Asn Gln Pro Gln Met Asn Gln Leu Trp Glu Leu Leu Gly Ala Gln 
        515                 520                 525             


Glu Ser Lys Ile Ala Leu Pro Arg Phe Asn Arg Val Ile Ala Arg Ala 
    530                 535                 540                 


Ala His Ala Trp Thr Ser Lys Glu Asp Arg Leu Ala Leu Pro Asp Ser 
545                 550                 555                 560 


Ala Ser Ser Lys Asp Leu Glu Ala Gln Pro Ala Arg Arg Cys Gln Tyr 
                565                 570                 575     


Val Leu Ile Lys Met Val Tyr Glu Arg Gly Phe Arg Thr Trp Leu Thr 
            580                 585                 590         


Ser Arg Ser Ala Asp Asp Leu Asn Ile Trp Ile Lys Gln Ala Thr Asp 
        595                 600                 605             


His Thr Thr Glu Ala Ala Lys Glu Phe His Lys His Gln Val Ser Lys 
    610                 615                 620                 


Glu Glu Leu Ala Gln Ile Ser Ala Arg Ser Ala Gly Leu Val Lys Leu 
625                 630                 635                 640 


Glu Pro Gly Glu Gly Phe Ala Lys Phe Leu Phe Lys Met Thr Ala Leu 
                645                 650                 655     


Thr Thr Thr Glu Phe Arg Val Gln Lys Gly Tyr Thr His Asp Ala Gly 
            660                 665                 670         


Arg Ala Arg Glu Gln Ala Ser Phe Leu Asp Asp Leu His Cys Asp Leu 
        675                 680                 685             


Val Ala Leu Ala Phe Asp Thr Tyr Leu Lys Asp Lys Lys Leu Gly Trp 
    690                 695                 700                 


Leu Tyr Arg Leu Arg Gln Asp Glu Ser Pro Gly Asn Pro Gln Ser Ser 
705                 710                 715                 720 


Ala Ala Asp Leu Pro Leu Gly Ser Val Ala Ser Ala Gln Asp Trp Gln 
                725                 730                 735     


Ala Val Leu Tyr Leu Val Leu His Leu Ile Pro Val Asp Asp Val Gly 
            740                 745                 750         


Arg Leu Leu His Arg Trp Arg Trp Trp Ser Asn Lys Tyr Asp Asp Glu 
        755                 760                 765             


His Leu Pro Ala Glu Gly Leu Gln Leu Ala Glu Ala Phe Thr Leu Tyr 
    770                 775                 780                 


Leu Asp Met His Asp Ala Lys Phe Asp Gly Ala Glu Ala Ile Thr Gly 
785                 790                 795                 800 


Ser Ala Ala Phe His Asp Leu Phe Asp Ser Asp Thr Thr Arg Lys Gln 
                805                 810                 815     


Val Phe Pro Asp Ala Leu Ala Ala Glu Ala Glu Gly Pro Arg Gln Ile 
            820                 825                 830         


Met Gln Arg Gly Leu Arg Glu Met Leu Arg Phe Gly Asp Met Ala Ser 
        835                 840                 845             


Phe Ala Pro Val Phe Ala Gly Arg Lys Val Thr Ala Glu Gln Val Lys 
    850                 855                 860                 


Glu Trp Gln Asn Leu Asp Ala Gln Val Ala Ala Ala His Glu Thr Arg 
865                 870                 875                 880 


Lys Lys Val His Glu Asp Tyr Lys Arg Gly Leu Arg Pro Ser Thr Glu 
                885                 890                 895     


Asn Glu Arg Leu Leu Glu Gln Lys Tyr Asp Leu Ala Ala Tyr Val Lys 
            900                 905                 910         


Ala Val Lys Thr Ile Thr Arg His Lys Arg Leu Ser His His Val Lys 
        915                 920                 925             


Leu Thr Asn His Val Arg Leu His Gln Ile Val Met Arg Val Leu Gly 
    930                 935                 940                 


Arg Leu Val Asp Tyr Ala Gly Leu Trp Glu Arg Asp Val Tyr Phe Val 
945                 950                 955                 960 


Leu Leu Ala Leu Ile Cys Leu Arg Gly Gln Thr Pro Arg Asp Val Phe 
                965                 970                 975     


Gln Asn Ala Tyr Gly Arg Lys Ala Leu Arg Gly Gly Gln Ile Arg Lys 
            980                 985                 990         


Ala Val Gln Asn Leu Glu Pro Glu  Tyr Lys Thr Ala Leu  Glu Arg His 
        995                 1000                 1005             


Phe Gly  Thr Gly Ala Phe Glu  Glu Gly Gly Val Val  Thr Ile Arg 
    1010                 1015                 1020             


Asn Asp  Leu Ala His Leu Asn  Met Met Gly Arg Ala  Ala Arg Ser 
    1025                 1030                 1035             


Asp Asp  Ala Arg Val Pro Leu  Asp Leu Thr Cys Gln  Ile Asp Arg 
    1040                 1045                 1050             


Thr Arg  Arg Leu Met Ser Tyr  Asp Arg Lys Leu Gln  Asn Ser Val 
    1055                 1060                 1065             


Ser Lys  Ser Val Thr Asp Leu  Met Glu Arg Glu Lys  Ile Arg Leu 
    1070                 1075                 1080             


Ser Phe  Arg Leu Asp Lys Gly  Lys Leu Thr Gln Ala  Thr Val Lys 
    1085                 1090                 1095             


Ala Asp  Leu Ile Lys His Phe  Lys Arg Lys Glu Leu  Thr Glu Asn 
    1100                 1105                 1110             


Leu His  Asp Pro Leu Phe Leu  Gly Met Val Ala Asp  Val Tyr Gly 
    1115                 1120                 1125             


Gly Thr  Val Gly Gln Leu Gln  Asn Asp Leu Thr Asp  Ala Gln Asp 
    1130                 1135                 1140             


Ile Ala  Ala Val Val Asn Gln  Thr Phe Ala Ala Val  Lys Ala Glu 
    1145                 1150                 1155             


Gln Asp  Ala Arg Arg Arg Pro  Arg Asn Asn Arg Ala  Gln Ser Gln 
    1160                 1165                 1170             


Asn Pro  Gly Gly Gly Thr Arg  Arg Asn Gly Gly Lys  Glu Lys Tyr 
    1175                 1180                 1185             


Gly Lys  His Pro Lys Gly Lys  Arg Thr Asp Arg His  
    1190                 1195                 1200 


<210>  986
<211>  1101
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  986

Met Arg Ile Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Ile Tyr Ser Glu 
            20                  25                  30          


Gln Ala Val Ser Asn Glu Thr Asn Asn Ile Leu Pro Val Lys Lys Met 
        35                  40                  45              


Asp Ser Phe Asn Leu Ser Ile Leu Asn Lys Thr Ile Ile Lys Phe Glu 
    50                  55                  60                  


Thr Val Lys Lys Gln Lys Leu Asn Leu Asp Gln Tyr Lys Ile Val Glu 
65                  70                  75                  80  


Lys Ile Phe Lys Tyr Pro Lys Gln Glu Leu Pro Lys Gln Ile Asn Ala 
                85                  90                  95      


Glu Glu Ile Leu Gln Phe Leu Asn His Lys Phe Gln Glu Pro Val Lys 
            100                 105                 110         


Tyr Trp Lys Asn Gly Lys Glu Glu Ser Phe Asn Leu Thr Leu Leu Ile 
        115                 120                 125             


Val Glu Ala Val Lys Thr Gln Glu Lys Arg Lys Leu Gln Pro Tyr Tyr 
    130                 135                 140                 


Asp Trp Lys Thr Trp Tyr Ile Gln Thr Lys Ser Asp Leu Leu Lys Lys 
145                 150                 155                 160 


Ser Ile Glu Asn Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg 
                165                 170                 175     


Lys Lys Ala Leu Leu Ala Trp Glu Thr Glu Phe Thr Thr Ser Gly Ser 
            180                 185                 190         


Ile Asp Leu Thr His Phe His Lys Val Tyr Met Thr Asp Val Leu Cys 
        195                 200                 205             


Thr Ala Leu Gln Lys Val Glu Pro Ser Ala Asp Glu Arg Gly Lys Met 
    210                 215                 220                 


Asn Ser Asn Ala Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Asn His 
225                 230                 235                 240 


Gln Pro Ala Ile Phe Gly Thr Arg Glu Ala Pro Asn Glu Val Asn Arg 
                245                 250                 255     


Ala Asp Asn Gln Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu 
            260                 265                 270         


Glu His Tyr Phe Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Ala Asp 
        275                 280                 285             


Asp Ile Ser His Tyr Leu Lys Ala Gln Thr Leu Lys Thr Thr Ile Glu 
    290                 295                 300                 


Lys Gln Leu Val Asn Ala Ile Arg Ala Asn Ile Ile Gln Gln Gly Lys 
305                 310                 315                 320 


Thr Asn His His Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile 
                325                 330                 335     


Arg Ile Lys Thr Asn Glu Ala Phe Val Leu Asn Leu Ile Gly Thr Cys 
            340                 345                 350         


Ala Phe Ala Ala Asn Asn Ile Arg Asn Met Val Asp Lys Glu Gln Ile 
        355                 360                 365             


Ser Asp Ile Leu Gly Lys Arg Glu Phe Ile Asp Ser Leu Thr Lys Ser 
    370                 375                 380                 


Arg Ile Ser Ser Gln Leu Tyr Ser Phe Phe Phe Gly Glu Asn Leu Ser 
385                 390                 395                 400 


Thr Asn Lys Ala Glu Lys Glu Thr Gln Leu Trp Gly Ile Arg Gly Ala 
                405                 410                 415     


Val Gln Gln Ile Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu 
            420                 425                 430         


Thr Thr Ile Phe Asn Ile Cys Lys Phe Glu Asn Pro Thr Asp Ala Asp 
        435                 440                 445             


Pro Lys Gln Gln Thr Asn Tyr Val Asp Ser Ile Tyr Lys Thr Leu Phe 
    450                 455                 460                 


Ile Lys Glu Leu Glu Lys Ile Pro Glu Ala Phe Ala Gln Gln Leu Lys 
465                 470                 475                 480 


Thr Gly Gly Ala Leu Ser Tyr Tyr Thr Val Glu Asn Leu Lys Thr Leu 
                485                 490                 495     


Leu Thr Thr Phe Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala 
            500                 505                 510         


Pro Gly Phe Lys Lys Val Leu Asn Gly Gly Ile Asn Tyr Gln Asn Ala 
        515                 520                 525             


Lys Gln Asp Glu Ser Phe Tyr Glu Leu Met Leu Glu Arg Tyr Leu Arg 
    530                 535                 540                 


Lys Glu Asn Phe Ala Glu Glu Ala Tyr Asn Ala Arg Tyr Phe Leu Leu 
545                 550                 555                 560 


Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Lys Phe Thr Ala Asp Arg 
                565                 570                 575     


Lys Ala Phe Ala Asp Ser Val Gly Phe Val Gln Leu Gln Asn Arg Lys 
            580                 585                 590         


Gln Ala Glu Asn Ser Lys Arg Pro Lys Ala Phe Ala Phe Glu Ala Val 
        595                 600                 605             


Arg Pro Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala Tyr Val 
    610                 615                 620                 


Gln Ser Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys Ala Thr 
625                 630                 635                 640 


Asp Glu Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val Phe Ile 
                645                 650                 655     


Lys Gly Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe Val Gln 
            660                 665                 670         


Val Pro Gln Pro Gln Leu Thr Thr Thr Asp Ser Asn Gln Gln Lys Ala 
        675                 680                 685             


Asp Lys Leu Asn Gln Leu Glu Ala Ser Ile Thr Ala Asp Cys Lys Leu 
    690                 695                 700                 


Thr Ala Gln Tyr Ala Lys Thr Asp Asp Ala Thr His Ile Ala Phe Tyr 
705                 710                 715                 720 


Val Phe Cys Lys Leu Leu Asp Ala Gly His Leu Ser Asn Leu Arg Asn 
                725                 730                 735     


Glu Leu Ile Lys Phe Arg Gly Ser Val Lys Asp Phe Asp Phe His His 
            740                 745                 750         


Leu Leu Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val Val Pro 
        755                 760                 765             


Thr Asp Tyr Arg Asp Leu Tyr Ser Ser Gly Ala Asp Cys Leu Ala Arg 
    770                 775                 780                 


Leu Arg Pro Phe Ile Glu Gln Gly Ala Asp Ile Lys Asn Trp Ser Asp 
785                 790                 795                 800 


Leu Tyr Val Gln Thr Asp Lys Gln Thr Pro Val Ile His Ala Gly Ile 
                805                 810                 815     


Glu Leu Ser Val Lys Tyr Gly Thr Thr Ala Leu Leu Glu Gln Leu Ile 
            820                 825                 830         


Thr Cys Asn Pro Lys Phe Arg Val Met Glu Asp Asn Phe Thr Lys Trp 
        835                 840                 845             


Ser Ala Gln Lys Lys Glu Ile Glu Glu Lys Val Asn Lys His Thr Asn 
    850                 855                 860                 


Leu His Gln Gln Trp Val Glu Ala Lys Glu Lys Asp Asp Arg Glu Arg 
865                 870                 875                 880 


Val Lys Ser Lys Lys Asn Phe Val Arg Glu Tyr Val Lys Lys Asn Tyr 
                885                 890                 895     


Val Asp Tyr Ile Asn Asn Cys Ile Glu Ile Asn Asn Tyr Asn Trp Leu 
            900                 905                 910         


Asp Asn Lys Leu His Phe Val His Leu Asn His Leu His His Leu Thr 
        915                 920                 925             


Ile Asp Ile Leu Gly Arg Met Ala Gly Phe Val Ala Leu Trp Glu Arg 
    930                 935                 940                 


Asp Phe Gln Tyr Ile Thr Lys Tyr Thr Ala Ala Lys Glu Gly Thr Asp 
945                 950                 955                 960 


Ala Leu Ser Phe Asp Gly Gly Leu Pro Arg Leu Lys Asp Lys Gln Glu 
                965                 970                 975     


Tyr Tyr Asn Lys Leu Phe Leu Ser Asp Lys Tyr Thr Lys Val Arg Asn 
            980                 985                 990         


His Ile Ala His Phe Asn Tyr Leu  Thr Lys Asp Ala Ala  Asp Phe Ala 
        995                 1000                 1005             


Leu Leu  Asp Leu Ile Asn Glu  Leu Arg Glu Leu Leu  His Tyr Gly 
    1010                 1015                 1020             


Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ala Phe Ile  Asp Leu Phe 
    1025                 1030                 1035             


Glu Lys  His Gly Met Ile Leu  Lys Leu Lys Leu Asn  Thr Asp His 
    1040                 1045                 1050             


Gln Leu  Val Val Glu Ser Ile  Glu Pro Lys Lys Ile  Tyr His Leu 
    1055                 1060                 1065             


Gly Ser  Thr Ala Lys Asp Lys  Pro Glu Tyr Gln Tyr  Thr Thr Asn 
    1070                 1075                 1080             


Gln Val  Met Thr Val Tyr Cys  Asn Met Cys Arg Ser  Leu Leu Glu 
    1085                 1090                 1095             


Met Lys  Lys 
    1100     


<210>  987
<211>  1183
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  987

Met Phe Ser Lys Ser Lys Lys Phe Ile Tyr Glu Lys Ile Val Ile Pro 
1               5                   10                  15      


Gln Asn Glu Gln Asn Ile Val Ile Ser Ala Leu Val Asn Cys Ser Leu 
            20                  25                  30          


Arg Lys Ser Leu Arg Lys Asp Val Ser Tyr Lys Thr Lys Ser Gly Glu 
        35                  40                  45              


Ile Lys Thr Tyr Asn Leu Pro Glu Leu Val Lys Lys Ser Met Arg Phe 
    50                  55                  60                  


Tyr Cys Leu Glu Gly Gln Arg Glu Pro Asp Glu Lys Glu Lys Tyr Glu 
65                  70                  75                  80  


Met Tyr Ile Leu Phe Ser Tyr Met Lys Glu Asp Lys Arg Thr Lys Asn 
                85                  90                  95      


Thr Asp Leu Leu Val Lys Ser Ile Ser Asn Gln Asn Thr Lys Val Lys 
            100                 105                 110         


Val Glu Asp Ile Asp Gly Asn Lys Leu Leu Lys Leu Ser Ile Ala Asp 
        115                 120                 125             


Thr Lys Lys Lys Pro Leu Trp Glu Tyr Leu Ile Lys Tyr Ala Asp Ser 
    130                 135                 140                 


Ser Arg Gln Arg Glu Leu Met Tyr Asp Ile Arg Lys Lys Ile Ile Leu 
145                 150                 155                 160 


Tyr Val Ala Gly Ile Glu Glu Tyr Glu Asn Ile Lys Glu Asp Ser Gly 
                165                 170                 175     


Leu Ser Lys Val Ser Trp Ser Lys Tyr Asn Ile Ser Asp Asn Lys Met 
            180                 185                 190         


Phe Phe Asp Ile Asn Ser Cys Thr Asp Lys Arg Lys Gln Asn Leu Glu 
        195                 200                 205             


Ile Lys Ile Arg Glu Ala Asn Ile Glu His Tyr Arg Asn Ala Ser Ser 
    210                 215                 220                 


Lys Leu Cys Asp Asp Glu Ser Ile Phe Trp Phe Gln His Phe Glu Gly 
225                 230                 235                 240 


Val Ile Glu Thr Leu Phe Ser Lys Lys Ser Lys Ile Ser Glu Glu Arg 
                245                 250                 255     


Leu Gly Cys Ala Tyr Ile Cys Asp Tyr Leu Trp Lys Asp Phe Leu Ser 
            260                 265                 270         


Tyr Leu Ala Thr Lys Tyr Ile Asp Leu Gly Lys Gly Val Tyr His Phe 
        275                 280                 285             


Thr Met Lys Asp Lys Leu Asp Met Leu Asn Lys Asn Glu Ala Val Thr 
    290                 295                 300                 


Asp Leu Arg Phe Gly Ile Val Ser Glu Lys Tyr Glu Lys Gly Ile Thr 
305                 310                 315                 320 


Ser Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Glu Leu Asp Arg Asn 
                325                 330                 335     


Ile Ala Ala Tyr Val Thr Phe Ala Ala Asp Ile Phe Ala Lys Ser Val 
            340                 345                 350         


Ile Lys Ser Asp Tyr Arg Thr Lys Lys Asp Asn Asn Ser Asp Val Leu 
        355                 360                 365             


Gln Tyr Ser Asp Lys Glu Phe Arg Asn Ser Glu Val Ile Arg Asp Asn 
    370                 375                 380                 


Ala Glu Lys Asn Ile Leu Gln Tyr Trp Gly Gly Tyr Ser Arg Trp Gly 
385                 390                 395                 400 


Thr Glu Asn Ser Lys Leu Pro Glu Asn Asn Lys Val Ser Asp Phe Gly 
                405                 410                 415     


Lys Leu Asp Val Ser Asp Leu Cys Ile Asp Ile Lys Lys His Leu Ala 
            420                 425                 430         


Gly Ile Arg Asn Ser Ser Val His Tyr Thr Thr Lys Ile Lys Asn Glu 
        435                 440                 445             


Ser Ala Ala Asp Gly Ser Asn Val Lys Ile Leu Phe Glu Lys Asp Leu 
    450                 455                 460                 


Ala Asp Ile Asn Ile Ile Tyr Ala Asp Lys Tyr Tyr Ser Asn Asn Val 
465                 470                 475                 480 


Trp Met Phe Tyr Ser Leu Glu Asp Ile Asn Lys Leu Ile Ala Phe Leu 
                485                 490                 495     


Tyr Lys Glu Lys Arg Val Ile Arg Gln Val Gln Ile Pro Ser Phe Ser 
            500                 505                 510         


Arg Ile Leu Lys Arg Lys Ala Met Gln Asp Val Ile Asn Glu Ile Phe 
        515                 520                 525             


Lys Asp Asp Phe Asp Glu Asn Ile Val Asn Pro Glu Leu Lys Glu Lys 
    530                 535                 540                 


Tyr Arg Asn Ser Leu Tyr Phe Met Leu Lys Glu Ile Tyr Tyr Asn Ala 
545                 550                 555                 560 


Phe Ile Ile Gln Pro Glu Leu Lys Glu Lys Phe Lys Asp Lys Ile Lys 
                565                 570                 575     


Thr Met Thr Ser Glu Leu Tyr Asn Lys Leu Lys Thr Ile Asp Lys Lys 
            580                 585                 590         


Glu Tyr Lys Ala Leu Tyr Cys Met Leu Ser Asn Glu Glu Ser Ala Leu 
        595                 600                 605             


Lys Asn Phe Ala Asp Arg Ile Tyr Ser Val Asp Gly Asp Asn Val Ser 
    610                 615                 620                 


Phe Ala Asp Ile Cys Lys Ile Leu Met Thr Asp Tyr Asn Met Gln Asn 
625                 630                 635                 640 


Gln Glu Lys Lys Asn Ile Glu Ser Met Glu Gln Lys Lys Lys Asn Lys 
                645                 650                 655     


Gly Lys Asp Glu Asn Tyr Lys His Phe Pro Leu Leu Leu His Lys Val 
            660                 665                 670         


Leu Lys Glu Leu Phe Ile Glu Tyr Leu Lys Gln Thr His Glu Leu Glu 
        675                 680                 685             


Phe Leu Arg Asn Asn Ile Cys Ile Lys Ser Asp Val Thr Met Glu Ser 
    690                 695                 700                 


Phe Glu Ser Gln Ile Lys Gly Val Glu Ile Tyr Lys Asp Leu Lys Glu 
705                 710                 715                 720 


Lys Ile Asp Lys Asn Asn Ser Leu Leu Asp Trp Tyr Val Ile Ala His 
                725                 730                 735     


Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asn Ile Lys Asn 
            740                 745                 750         


Tyr Ile Gln Phe Ala Thr Asn Ile Asp Lys Arg Ala Glu Ser Val Lys 
        755                 760                 765             


Asn Leu Ile Glu Ser Gly Met Val Lys Arg Ile Gln Tyr Tyr Asp Asp 
    770                 775                 780                 


Ile Val Arg Thr Leu Glu Phe Ser Ala Gln Tyr Ile Gly Lys Ile Ser 
785                 790                 795                 800 


Asn Asn Ile Asn Asp Tyr Phe Asn Ser Glu Asp Glu Tyr Val Ser Phe 
                805                 810                 815     


Leu Ser Lys Tyr Val Gly Phe Ile Asn Asp Lys Ser Glu Asp Val Leu 
            820                 825                 830         


Thr Glu Leu Lys Asp Phe Cys Arg Glu Lys Ile Asn Asn Gly Ser Gln 
        835                 840                 845             


Ile Ile Gly Ile Tyr Tyr Gly Gly Asp Asn Val Ile Ile Asn Arg Asn 
    850                 855                 860                 


Val Ile Tyr Ala Gln Met Tyr Ser Asn Ala Glu Val Phe Ser Asn Ile 
865                 870                 875                 880 


Tyr Lys Lys Val Thr Lys Asn Asp Ile Ile Asn Tyr Tyr Glu Lys Gln 
                885                 890                 895     


Asn Asp Leu Lys Asp Val Phe Lys Ser Gly Val Cys Gln Asn Glu Gly 
            900                 905                 910         


Glu Gln Arg Ser Leu Cys Glu Phe Gln Gln Leu Lys Asn Arg Ile Glu 
        915                 920                 925             


Leu Thr Glu Leu Ser Thr Tyr Ala Asp Met Val Asn Asp Phe Met Ala 
    930                 935                 940                 


Gln Phe Val Glu Trp Ala Tyr Leu Arg Glu Arg Asp Leu Met Tyr Phe 
945                 950                 955                 960 


Gln Leu Gly Ile His Tyr Ile Arg Leu Phe Tyr Ser Asp Asn Val Leu 
                965                 970                 975     


Asp Glu Lys Tyr His Lys Leu Ser Asp Asn Val Ile Asp Ile Glu Glu 
            980                 985                 990         


Gly Ala Leu Leu Tyr Gln Ile Val  Ala Met Tyr Asp Tyr  Glu Leu Arg 
        995                 1000                 1005             


Ile Phe  Glu Thr Asp Asn Ser  Gly Asn Ala Lys Arg  Ile Gly Gln 
    1010                 1015                 1020             


Gly Gly  Pro Gly Lys Ser Ile  Pro Val Phe Leu Lys  Lys Tyr Cys 
    1025                 1030                 1035             


Asn Gly  Thr Asp Val Tyr Glu  Cys Gly Leu Glu Leu  Phe Glu Asp 
    1040                 1045                 1050             


Ile Asn  Gln His Glu His Ile  Ile Arg Phe Arg Asn  Asp Ile Ala 
    1055                 1060                 1065             


His Met  Arg Tyr Met Ser Asn  Gln Ala Met Asn Ile  Met Ser Ile 
    1070                 1075                 1080             


Val Ser  Asn Ile Tyr Lys Ser  Phe Phe Val Tyr Asp  Thr Lys Leu 
    1085                 1090                 1095             


Lys Lys  Ser Ile Ser Leu Val  Phe Lys Asn Ile Leu  Met Arg Tyr 
    1100                 1105                 1110             


Gly Val  Ile Ala Asp Leu Val  Phe Ser Tyr Asn Asn  Lys Asn Gln 
    1115                 1120                 1125             


Ser Ile  Lys Asp Asp Met Asp  Ile Asn Ile Ile Asn  Ile Lys Asn 
    1130                 1135                 1140             


Leu Lys  Ser Asp Lys Tyr Val  Tyr Lys Ile Val Asn  Glu Asp Ile 
    1145                 1150                 1155             


Val Lys  Gln Val Glu Ile Glu  Ile Arg Asn Gln Val  Phe Leu Glu 
    1160                 1165                 1170             


Gln Leu  His Asn Leu Leu Tyr  Phe Ser Arg 
    1175                 1180             


<210>  988
<211>  1353
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  988

Met Lys Val Thr Lys Ala Glu Lys Leu Arg Val Ala Val Ser Arg Lys 
1               5                   10                  15      


Leu Asn Asn Glu Asp Lys Arg Ala Val Leu Tyr Lys Thr Pro Asn Pro 
            20                  25                  30          


Gly Gln Thr Cys Gly Thr Val Lys Lys Gln Leu Ala Asn Arg Val Glu 
        35                  40                  45              


Arg Ala Asn Lys Leu Tyr Gly Val Phe Phe Arg Ser Asp Val Pro Glu 
    50                  55                  60                  


Thr Leu Gln Tyr His Phe Glu Glu Leu Val Thr Tyr Ala Ala Gln Ser 
65                  70                  75                  80  


Thr Ser Pro Asn Glu Phe Arg Gln Lys Ala Ser Gln Tyr Arg Glu Cys 
                85                  90                  95      


Glu Lys Lys Asp Lys Phe Gly Lys Met Arg Lys Tyr Pro Ile Phe Arg 
            100                 105                 110         


Cys Ser Tyr Ala Pro Ser Gly Lys Asn Met Lys Lys Val Met Glu Leu 
        115                 120                 125             


Tyr Val Arg Glu Arg Met Lys Asp Glu Trp Gln Ser Gln Ala Tyr Arg 
    130                 135                 140                 


Thr Ala Ala Ile Glu Ile Leu Leu Cys Ile Cys Asn Lys Asp Phe Ser 
145                 150                 155                 160 


Lys Gln Leu Ser Arg Val Asp Ala Arg Ile Phe Ala Asp Phe Tyr Asn 
                165                 170                 175     


Ala Ser Lys Ala Cys Pro Gln Pro Tyr Ile Gly Lys Ser Thr Gly Val 
            180                 185                 190         


Leu Glu Ala Ala Phe Thr Ser Val Met Lys Gln Met Ser Leu His Ala 
        195                 200                 205             


Lys Ala Asn Ala Ser Asn Lys Ile Trp Trp Leu Gln Asn Gln Leu Arg 
    210                 215                 220                 


Thr Ile Glu Leu Asn Lys Lys Ile Val Lys Ile Ser Asp Phe Lys Tyr 
225                 230                 235                 240 


Glu Tyr Ala Thr Glu Asp Arg Met Arg Ala Ile Leu Val Arg Met Arg 
                245                 250                 255     


Lys Ser Leu Lys Arg Gly Thr Asn Gly Asp Ile Ala Val Ala Leu Leu 
            260                 265                 270         


Gln Gly Ile Ala Gln Met Asn Gly Lys Thr Leu Ser Gly Val Leu Glu 
        275                 280                 285             


Glu Leu Ser Ala Asn Ser Glu Thr Lys Glu Gln Leu Ile Lys Phe Leu 
    290                 295                 300                 


Lys Ala Val His Glu Asp Tyr His Lys Thr Pro Ile Leu Lys Ala Ile 
305                 310                 315                 320 


Arg Asn Gln Asp Val Lys Val Gln Val His Glu Val Asp Pro Val Ser 
                325                 330                 335     


Pro Glu Gly Arg Ala Leu Asp Leu Ala Ser Ile Asn Val Ser Lys Gly 
            340                 345                 350         


Asn Glu Arg Lys Lys Tyr Lys Val Ala Leu Thr Gln Thr Leu Gly Asn 
        355                 360                 365             


Tyr Ala Lys Ser Pro Lys Asp Ala Thr Gln Thr Leu Lys Ala Ile Lys 
    370                 375                 380                 


Gly Val Leu Leu Asp Tyr Phe Met Trp Leu Asp Ser Asp Val Lys Ala 
385                 390                 395                 400 


Glu Phe Leu Glu Asp Asn Asn Leu Trp Lys Ile Pro Asn Arg Thr Glu 
                405                 410                 415     


Glu Tyr Phe Asp Asn Asn Phe Val Pro Ile Asp Asp Lys Lys Asp Asp 
            420                 425                 430         


Lys Ile Glu Ala Ile Glu Asp Phe Ala Ser Ile Trp Arg Gln Glu Arg 
        435                 440                 445             


Val Lys Asn Ser Arg Ile Lys Ala Arg Met Asn Tyr Val Asn Cys Gly 
    450                 455                 460                 


Lys Tyr Gln Gln Leu Ile Lys Gln Glu Thr Asp Asp Phe Arg Ile Cys 
465                 470                 475                 480 


Trp Ile Ser Tyr Ala Lys Asp Phe Val Glu Lys Asn Tyr Val Ser Lys 
                485                 490                 495     


Asn Arg Gln Phe Thr Gln Gly Asp Cys Phe Ser Thr Lys Met Leu Leu 
            500                 505                 510         


Glu Cys Trp Lys Glu Ile Ile Arg Phe Ile Cys Gly Lys Tyr Ile Asp 
        515                 520                 525             


Ile Gly Lys Ala Val Tyr His Phe Ala Met Pro Glu Thr Met Asn Ala 
    530                 535                 540                 


Arg Asp Ser Leu Ala Tyr Gly Val Leu Gly Glu Lys Tyr Lys Glu Gly 
545                 550                 555                 560 


Ile Ser Ser Phe Asp Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln 
                565                 570                 575     


Arg Asp Ile Ala Lys Ala Ala Val Ala Ala Ile His Ala Phe Ser Gly 
            580                 585                 590         


Ser Val Ile Asp Asp Lys Lys Pro Val Glu Asp Ile Leu Phe Ile Lys 
        595                 600                 605             


Asp Glu Glu Leu Gln Glu His Ala Lys Ala Asp Asp Val Ile Val Lys 
    610                 615                 620                 


Gln Ile Leu Arg Phe Tyr Gly Gly Phe Ser Ser Val Glu Gly Arg Glu 
625                 630                 635                 640 


Lys Leu Glu Gly Met Ala Leu Ala Lys Glu Val Leu Ser Gln Leu Lys 
                645                 650                 655     


Ala Ile Arg Asn Glu Asn Phe His Phe Thr Gln Gly Lys Arg Lys Asn 
            660                 665                 670         


Val Glu Glu Asn Ile Pro Leu Thr Lys Ala Leu Trp Glu Asn Glu Glu 
        675                 680                 685             


Lys Val Tyr Arg Gln Thr Val Lys Glu Thr Tyr Tyr Ser Asn Asn Val 
    690                 695                 700                 


Ser Met Phe Tyr Ser Gln Glu Val Ile Gln Lys Leu Val Ala Glu Leu 
705                 710                 715                 720 


Tyr Gln Asn Asn Asn Val Ala Glu Ala Gln Ile Pro Ala Phe Arg Thr 
                725                 730                 735     


Ile Trp Lys Arg Lys Asp Leu Pro Glu Tyr Ile Gly Ser Leu Asn Ile 
            740                 745                 750         


Ser Trp Asp Lys Thr Glu Pro Lys Gln Val Ile Tyr Glu Gly Ala Leu 
        755                 760                 765             


Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Lys Ser Gly 
    770                 775                 780                 


Glu Ala Lys Lys Leu Phe Phe Asp Ala Val Met Asp Asn Ala Thr Glu 
785                 790                 795                 800 


Met Glu Lys Ser Ser Asn Ala Asp Ser Arg Asn Gln Glu Lys Lys Ala 
                805                 810                 815     


Leu Ala Asn Ala Gly Lys Asn Phe Arg Asp Tyr Val Asn Gly Leu Asn 
            820                 825                 830         


Ala Ser Thr Leu Gly Glu Val Cys Gln Phe Ile Gln Asn Glu Tyr Asn 
        835                 840                 845             


Gln Gln Asn Arg Gly Lys Gln Glu Gln Glu Ile Tyr Lys His Phe Lys 
    850                 855                 860                 


Met Leu Leu Pro Ile Cys Met Arg Lys Ala Phe Gln Arg Tyr Ile Asp 
865                 870                 875                 880 


Glu Lys His Ser Phe Ile Lys Lys Pro Gly Glu Leu Pro Gln Thr Thr 
                885                 890                 895     


Glu Asp Tyr Leu Glu Asn Val Lys Val Ala Cys Pro Glu Lys Lys Ile 
            900                 905                 910         


Lys Leu Gly Arg Trp Phe Thr Phe Ala His Phe Ile His Pro Arg Glu 
        915                 920                 925             


Leu Asn Phe Leu Ile Gly Asp Phe Lys Asn Tyr Ile Gln Tyr Arg Glu 
    930                 935                 940                 


Asp Val Leu Arg Arg Ser Glu His Ala Gly Gln Phe Ser Asp Thr Thr 
945                 950                 955                 960 


Glu Arg Asp Gly Glu Lys Ala Val Val Asp His Ala Val Gln Lys Ala 
                965                 970                 975     


Lys Asp Ile Leu Gly Val Leu Glu Phe Val Arg His Ile Ser Gly Arg 
            980                 985                 990         


Val Ser Asn Glu Phe Thr Asp Tyr  Tyr Ala Asp Arg Ala  Glu Tyr Asp 
        995                 1000                 1005             


Glu Tyr  Met Ala Lys Tyr Phe  Glu Pro Asp Val Gln  Ile Glu Gln 
    1010                 1015                 1020             


Tyr Asp  Leu Tyr Gly Asp Ala  Lys Asn Ala Lys Val  Ile Arg Asn 
    1025                 1030                 1035             


Ile Glu  Leu Ala Arg Met Tyr  Ala Gly Asp Ser Leu  Met Ser Ala 
    1040                 1045                 1050             


Ser Tyr  Arg Lys Ile Thr Lys  Lys Glu Ile Glu Thr  Tyr Tyr Ala 
    1055                 1060                 1065             


Lys Lys  Asp Glu Ile Ala Gln  Leu Gln Ser Gln Gly  Ile Cys Asn 
    1070                 1075                 1080             


Ser Lys  Lys Glu Gln Glu Asp  Ile Val Ala Phe Gln  Lys Leu Lys 
    1085                 1090                 1095             


Asn Arg  Ile Thr Leu Asn Glu  Val Thr Asp Leu Trp  Ser Leu Val 
    1100                 1105                 1110             


Asn Glu  Leu Leu Gly Asn Leu  Val Ser Leu Ala Tyr  Leu Arg Glu 
    1115                 1120                 1125             


Arg Asp  Glu Met Tyr Leu Phe  Leu Gly Phe Tyr Tyr  Met Ala Leu 
    1130                 1135                 1140             


Arg His  Pro Glu Gly Trp Thr  Asn Glu Ile Met Asn  Ser Val Ser 
    1145                 1150                 1155             


Asn Glu  Lys Tyr Ala Val Lys  Glu Gly Leu Val Leu  Tyr Gln Thr 
    1160                 1165                 1170             


Val Ala  Val Phe Asp Phe Gly  Thr Lys Leu Leu Phe  Gln Asn Asp 
    1175                 1180                 1185             


Asn Gln  Lys Trp Glu Glu Thr  Thr Gly Tyr Lys Trp  Gln His Phe 
    1190                 1195                 1200             


Ile Asp  Asn His Lys Glu Ser  Tyr Ala Cys Ile Leu  Pro Leu Phe 
    1205                 1210                 1215             


Glu Ile  Ala Lys Cys Glu Thr  Glu Ala Arg Ala Val  Arg Asn Tyr 
    1220                 1225                 1230             


Val Asp  His Phe Lys Tyr Tyr  Ser Asn Glu Asp Arg  Ser Ile Leu 
    1235                 1240                 1245             


Glu Leu  Tyr Gly Lys Phe Tyr  Thr His Leu Phe Gly  Tyr Ser Thr 
    1250                 1255                 1260             


Arg Leu  Arg Lys Ser Val Leu  Gln Ile Leu Ala Gln  Thr Leu Glu 
    1265                 1270                 1275             


Lys His  Gly Ile Ser Ala Gly  Ile Gln Phe Asp Gly  Thr Thr Val 
    1280                 1285                 1290             


Lys Ala  Thr Arg Cys Asp Met  Lys Ser Val Glu Phe  Thr Tyr Lys 
    1295                 1300                 1305             


Tyr Glu  Glu Lys Leu Asn Glu  Gln Lys Thr Val Leu  Arg Thr Ile 
    1310                 1315                 1320             


Ser Leu  Pro Ala Lys Ser Glu  Gly Phe Ile Thr Ala  Val Cys Glu 
    1325                 1330                 1335             


Met Leu  Lys Gln Lys Lys Gly  Asp His Thr Glu Asn  Thr Leu Cys 
    1340                 1345                 1350             


<210>  989
<211>  1159
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  989

Met Lys Val Thr Lys Val Gly Gly Ile Ser His Lys Lys Tyr Thr Ser 
1               5                   10                  15      


Glu Gly Arg Leu Val Lys Ser Glu Ser Glu Glu Asn Arg Thr Asp Glu 
            20                  25                  30          


Arg Leu Ser Ala Leu Leu Asn Met Arg Leu Asp Met Tyr Ile Lys Asn 
        35                  40                  45              


Pro Ser Asn Thr Glu Thr Lys Glu Asn Lys Lys Arg Ile Gly Lys Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Met Val Tyr Leu Lys Asp Asn Thr Leu 
65                  70                  75                  80  


Ser Leu Lys Asn Gly Lys Lys Glu Asn Ile Asp Arg Glu Tyr Ser Glu 
                85                  90                  95      


Thr Asp Ile Ser Glu Tyr Asp Val Arg Asp Ser Lys Asn Phe Ala Val 
            100                 105                 110         


Leu Lys Lys Ile Tyr Leu Asn Glu Asn Val Asn Ser Glu Glu Leu Glu 
        115                 120                 125             


Val Phe Arg Lys Asp Ile Lys Lys Lys Leu Asn Lys Ile Asn Ser Leu 
    130                 135                 140                 


Lys Tyr Ser Phe Glu Lys Asn Lys Ala Asn Tyr Gln Lys Ile Asn Glu 
145                 150                 155                 160 


Asn Asn Ile Glu Lys Val Glu Gly Lys Ser Lys Arg Asn Ile Ile Tyr 
                165                 170                 175     


Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asp Ala Tyr Val Ser Asn Val 
            180                 185                 190         


Lys Glu Ala Phe Asp Lys Leu Tyr Lys Glu Glu Asp Ile Ala Lys Leu 
        195                 200                 205             


Val Leu Lys Ile Glu Asn Leu Thr Lys Leu Glu Lys Ser Lys Ile Arg 
    210                 215                 220                 


Glu Phe Tyr His Glu Ile Ile Gly Arg Lys Asn Asp Lys Glu Asn Phe 
225                 230                 235                 240 


Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Met Lys Glu 
                245                 250                 255     


Leu Ile Glu Lys Val Pro Asn Met Ser Glu Leu Lys Lys Ser Gln Val 
            260                 265                 270         


Phe Tyr Lys Tyr Tyr Leu Asn Lys Glu Glu Leu Asn Asp Lys Asn Ile 
        275                 280                 285             


Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln Leu Leu 
    290                 295                 300                 


Lys Asn Tyr Val Tyr Lys Gly Leu Ser Asn Ile Ser Asn Asp Lys Ile 
305                 310                 315                 320 


Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu Asn Lys 
                325                 330                 335     


Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys Tyr Asn 
            340                 345                 350         


Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile Ala Arg 
        355                 360                 365             


Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val Ser Ser 
    370                 375                 380                 


Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn Glu Asn 
385                 390                 395                 400 


Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn Lys Gly 
                405                 410                 415     


Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn Glu Asn 
            420                 425                 430         


Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser Tyr Asp 
        435                 440                 445             


Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala Asn Ile 
    450                 455                 460                 


Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe Asn Leu 
465                 470                 475                 480 


Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala Pro Ser 
                485                 490                 495     


Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys Lys Leu 
            500                 505                 510         


Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe Arg Tyr 
        515                 520                 525             


Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg Phe Glu 
    530                 535                 540                 


Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys Leu Tyr 
545                 550                 555                 560 


Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp Lys Thr 
                565                 570                 575     


Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp Ala Gln 
            580                 585                 590         


Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn Tyr Phe 
        595                 600                 605             


Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Lys Glu Ile Ile Glu 
    610                 615                 620                 


Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr Lys Leu 
625                 630                 635                 640 


Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr Leu Ala 
                645                 650                 655     


Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp Glu Glu 
            660                 665                 670         


Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu Lys Gly 
        675                 680                 685             


Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile Tyr Ile 
    690                 695                 700                 


Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys Gln Glu 
705                 710                 715                 720 


Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile Glu Ile 
                725                 730                 735     


Pro His Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly Asn Ile 
            740                 745                 750         


Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu Lys Leu 
        755                 760                 765             


Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu Lys Tyr 
    770                 775                 780                 


Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu Leu Ile 
785                 790                 795                 800 


Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe Glu Leu 
                805                 810                 815     


Glu Val Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn Lys Ile 
            820                 825                 830         


Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile Tyr Phe 
        835                 840                 845             


Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile Lys Lys 
    850                 855                 860                 


Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala Lys Tyr 
865                 870                 875                 880 


Lys Ile Ser Leu Lys Glu Leu Lys Glu Tyr Ser Asn Lys Lys Asn Glu 
                885                 890                 895     


Ile Glu Lys Asn Tyr Arg Met Gln Gln Asn Leu His Arg Lys Tyr Ala 
            900                 905                 910         


Arg Pro Lys Lys Asp Glu Lys Phe Asn Asp Lys Asp Tyr Lys Glu Tyr 
        915                 920                 925             


Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys Asn Lys 
    930                 935                 940                 


Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu Lys Ile 
945                 950                 955                 960 


Leu His Arg Ile Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp Leu Arg 
                965                 970                 975     


Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu Glu Ile 
            980                 985                 990         


Phe Asn Phe Asp Asn Ser Lys Asn  Val Lys Tyr Lys Ser  Gly Gln Ile 
        995                 1000                 1005             


Val Glu  Lys Tyr Ile Asn Phe  Tyr Lys Glu Leu Tyr  Lys Asp Asn 
    1010                 1015                 1020             


Val Glu  Lys Arg Ser Ile Tyr  Ser Asp Lys Lys Val  Lys Lys Leu 
    1025                 1030                 1035             


Lys Gln  Glu Lys Lys Asp Leu  Tyr Ile Arg Asn Tyr  Ile Ala His 
    1040                 1045                 1050             


Phe Asn  Tyr Ile Pro His Ala  Glu Ile Ser Leu Leu  Glu Val Leu 
    1055                 1060                 1065             


Glu Asn  Leu Arg Lys Leu Leu  Ser Tyr Asp Arg Lys  Leu Lys Asn 
    1070                 1075                 1080             


Ala Val  Met Lys Ser Val Val  Asp Ile Leu Lys Glu  Tyr Gly Phe 
    1085                 1090                 1095             


Val Ala  Thr Phe Lys Ile Gly  Ala Asp Lys Lys Ile  Gly Ile Gln 
    1100                 1105                 1110             


Thr Leu  Glu Ser Glu Lys Ile  Val His Leu Lys Asn  Leu Lys Lys 
    1115                 1120                 1125             


Lys Lys  Leu Met Thr Asp Arg  Asn Ser Glu Glu Leu  Cys Lys Leu 
    1130                 1135                 1140             


Val Lys  Val Met Phe Glu Tyr  Lys Met Glu Glu Lys  Lys Ser Glu 
    1145                 1150                 1155             


Asn 
    


<210>  990
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  990

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Tyr Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  991
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  991

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Asn Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Tyr Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Val 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Met 
    690                 695                 700                 


Tyr Ile Gly Asn Asp Glu Gln Ile Asn Thr Ser Leu Ala Gly Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Lys Ile Leu Lys Tyr Thr Glu Ser Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Lys Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Lys Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Glu 
        915                 920                 925             


Ser Tyr Lys Gln Ala Ile Lys Asn Ile Glu Glu Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Arg Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Glu Asn Lys  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Lys Phe Tyr Lys Glu  Leu His Gln 
    1010                 1015                 1020             


Asn Asp  Glu Val Lys Ile Asn  Lys Tyr Ser Ser Ala  Asn Ile Lys 
    1025                 1030                 1035             


Val Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Met Asn Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Lys Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Lys Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Glu  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  992
<211>  1143
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  992

Met Arg Val Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Val Tyr Ser Gly 
            20                  25                  30          


Gln Pro Val Ser Asn Glu Thr Cys Asn Ile Leu Pro Glu Lys Lys Arg 
        35                  40                  45              


Gln Ser Phe Asp Leu Ser Ile Glu Asn Lys Thr Leu Lys Arg Arg Asp 
    50                  55                  60                  


Asp Val Asp Lys Thr Lys Lys Gly Lys Tyr Asp Ile Val Arg Lys Ile 
65                  70                  75                  80  


Ile Lys Tyr Gly Glu Leu Pro Gln Ser Ile Asn Asp Val Asp Ile Leu 
                85                  90                  95      


Glu Phe Leu Asn His Lys Phe Gln Lys Pro Val Lys Tyr Trp Lys Asn 
            100                 105                 110         


Gly Lys Glu Glu Ser Phe Asn Leu Thr Leu Leu Ile Val Glu Ala Val 
        115                 120                 125             


Lys Thr Gln Asp Arg Gln Lys Leu Gln Pro Tyr Tyr Asp Trp Lys Thr 
    130                 135                 140                 


Trp Tyr Ile Gln Thr Lys Ser Asp Leu Leu Lys Lys Ser Ile Glu Asn 
145                 150                 155                 160 


Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg Lys Lys Ala Leu 
                165                 170                 175     


Leu Ala Trp Glu Thr Glu Phe Thr Thr Ser Gly Lys Ile Asp Leu Thr 
            180                 185                 190         


His Tyr His Lys Val Tyr Met Thr Asp Val Leu Cys Thr Ala Leu Gln 
        195                 200                 205             


Lys Val Glu Pro Ser Thr Asp Lys Lys Gly Lys Ile Asn Thr Asn Ala 
    210                 215                 220                 


Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Thr His Gln Pro Ala Ile 
225                 230                 235                 240 


Phe Gly Thr Arg Gln Ala Pro Asn Asn Val Asn Arg Ala Asp Asp Arg 
                245                 250                 255     


Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu Glu His Tyr Phe 
            260                 265                 270         


Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Ala Asp Asp Ile Glu His 
        275                 280                 285             


Tyr Leu Lys Thr Gln Thr Leu Lys Thr Thr Ile Glu Lys Gln Leu Val 
    290                 295                 300                 


Asn Ala Ile Arg Ala Asn Ile Ile Gln Gln Gly Lys Thr Asn His His 
305                 310                 315                 320 


Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile Arg Ile Lys Thr 
                325                 330                 335     


Asn Glu Ala Phe Val Leu Asn Leu Thr Gly Thr Cys Ala Phe Ala Ala 
            340                 345                 350         


Asn Asn Ile Arg Asn Met Val Asp Asn Glu Gln Thr Asn Asp Ile Leu 
        355                 360                 365             


Gly Lys Gly Asp Phe Ile Lys Ser Leu Leu Lys Asp Asn Thr Asn Gly 
    370                 375                 380                 


Gln Leu Tyr Ser Phe Phe Phe Gly Glu Ser Leu Ser Thr Asn Lys Ala 
385                 390                 395                 400 


Glu Lys Glu Thr Gln Leu Trp Gly Ile Arg Gly Ala Val Gln Gln Ile 
                405                 410                 415     


Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu Lys Thr Val Phe 
            420                 425                 430         


Asn Ile Ser Asn Phe Glu Asn Pro Thr Ile Thr Asp Pro Lys Gln Gln 
        435                 440                 445             


Thr Asn Tyr Ala Asp Thr Ile Tyr Lys Ala Leu Phe Ile Lys Glu Leu 
    450                 455                 460                 


Glu Lys Ile Pro Asn Ala Phe Ala Gln Gln Leu Lys Thr Gly Gly Ala 
465                 470                 475                 480 


Leu Ser Tyr Tyr Thr Ile Glu Asn Leu Lys Ser Leu Leu Thr Thr Phe 
                485                 490                 495     


Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala Pro Gly Phe Lys 
            500                 505                 510         


Lys Val Phe Asn Gly Gly Ile Asn Tyr Gln Asn Ala Lys Gln Asp Glu 
        515                 520                 525             


Ser Phe Tyr Glu Leu Met Leu Glu Arg Tyr Leu Arg Lys Glu Asn Phe 
    530                 535                 540                 


Ala Glu Glu Ala Tyr Asn Ala Arg Tyr Phe Leu Leu Lys Leu Ile Tyr 
545                 550                 555                 560 


Asn Asn Leu Phe Leu Pro Gly Phe Thr Arg Asp Arg Lys Ala Phe Ala 
                565                 570                 575     


Asp Ser Val Gly Phe Val Gln Met Gln Asn Lys Lys Gln Ala Glu Lys 
            580                 585                 590         


Val Asn Pro Lys Lys Arg Glu Ala Tyr Ala Phe Glu Ala Val Arg Pro 
        595                 600                 605             


Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala Tyr Val Gln Ser 
    610                 615                 620                 


Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys Ala Thr Asp Glu 
625                 630                 635                 640 


Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val Phe Val Lys Gly 
                645                 650                 655     


Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe Val Gln Val Pro 
            660                 665                 670         


Gln Pro Gln Leu Thr Ala Thr Ala Ser Asn Gln Gln Lys Ala Asp Lys 
        675                 680                 685             


Leu Asn Gln Leu Glu Ala Ser Ile Thr Ala Asp Cys Lys Leu Thr Pro 
    690                 695                 700                 


Gln Tyr Ala Lys Ala Asp Asn Ala Thr His Ile Ala Phe Tyr Val Phe 
705                 710                 715                 720 


Cys Lys Leu Leu Asp Ala Gly His Leu Ser Asn Leu Arg Asn Glu Leu 
                725                 730                 735     


Ile Lys Phe Arg Glu Ser Val Asn Glu Phe Lys Phe His His Leu Leu 
            740                 745                 750         


Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val Val Pro Thr Asp 
        755                 760                 765             


Tyr Arg Asp Leu Tyr Ser Ser Glu Ala Asp Cys Leu Ala Arg Leu Arg 
    770                 775                 780                 


Pro Phe Ile Glu Gln Gly Ala Asp Ile Thr Asn Trp Ser Asp Leu Phe 
785                 790                 795                 800 


Val Gln Ser Asp Lys His Ser Pro Val Ile His Ala Asn Ile Glu Leu 
                805                 810                 815     


Ser Val Lys Tyr Gly Thr Thr Lys Leu Leu Glu Gln Ile Ile Asn Lys 
            820                 825                 830         


Asp Pro Gln Phe Lys Thr Thr Glu Ala Asn Phe Thr Ala Trp Asn Thr 
        835                 840                 845             


Ala Gln Lys Ser Ile Glu Gln Leu Ile Lys Gln Arg Glu Asp His His 
    850                 855                 860                 


Glu Gln Trp Val Lys Ala Lys Asn Ala Asp Asp Lys Glu Lys Gln Glu 
865                 870                 875                 880 


Arg Lys Arg Glu Lys Ser Asn Phe Ala Gln Lys Phe Ile Glu Lys His 
                885                 890                 895     


Gly Asp Asp Tyr Leu Asp Ile Cys Asp Tyr Ile Asn Thr Tyr Asn Trp 
            900                 905                 910         


Leu Asp Asn Lys Met His Phe Val His Leu Asn Arg Leu His Gly Leu 
        915                 920                 925             


Thr Ile Glu Leu Leu Gly Arg Met Ala Gly Phe Val Ala Leu Phe Asp 
    930                 935                 940                 


Arg Asp Phe Gln Met Leu Asp Ala Lys Arg Ile Ser Asp Leu Tyr Gln 
945                 950                 955                 960 


Leu Lys Ser Phe Ile Ser Phe Arg Glu Ile Thr Ser Glu Leu Asp Lys 
                965                 970                 975     


Asn Asn Asp Ile Thr Glu Ile Asn Leu Ile Lys Asp Lys Glu Ile Ile 
            980                 985                 990         


Lys Arg Asp Gly Thr Pro Ile Thr  Glu Ala Asp Arg Asn  Ser Leu Lys 
        995                 1000                 1005             


Ser Cys  Ile Gln Ser Lys Arg  Glu Tyr Tyr Gln Lys  Thr Tyr Phe 
    1010                 1015                 1020             


Lys Glu  His Thr Asn Pro Phe  Thr Asp Arg Asn Tyr  Ile Ala His 
    1025                 1030                 1035             


Phe Asn  Tyr Leu Ser Thr Asn  Thr Gly Asn His Ser  Leu Ile Lys 
    1040                 1045                 1050             


Leu Ile  Asn Lys Leu Arg Asp  Leu Leu His Tyr Asp  Arg Lys Leu 
    1055                 1060                 1065             


Lys Asn  Ala Val Ser Lys Ala  Phe Ile Asp Leu Phe  Asp Lys His 
    1070                 1075                 1080             


Gly Met  Ile Leu Lys Leu Lys  Leu Asn Thr Asp His  Gln Leu Glu 
    1085                 1090                 1095             


Val Glu  Ser Leu Glu Pro Lys  Lys Ile Tyr His Leu  Gly Ser Ser 
    1100                 1105                 1110             


Ala Lys  Asp Lys Pro Glu Tyr  Gln Tyr Cys Thr Asn  Gln Val Met 
    1115                 1120                 1125             


Met Ala  Tyr Cys Asn Met Cys  Arg Ser Leu Leu Glu  Met Lys Lys 
    1130                 1135                 1140             


<210>  993
<211>  1125
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  993

Leu Lys Arg Thr Tyr Arg Phe Glu Thr Asn Tyr Gly Glu Lys Asn Thr 
1               5                   10                  15      


Phe Asn Leu Pro Asp Leu Val Lys Lys Ser Ile Lys Ile Tyr Cys Thr 
            20                  25                  30          


Asp Glu Lys Arg Lys Leu Asn Asp Arg Glu Glu Gln Glu Met Tyr Val 
        35                  40                  45              


Leu Phe Ser Tyr Met Tyr Glu Asp Lys Tyr Lys Asp Arg Gln Lys Val 
    50                  55                  60                  


Leu Ile Ala Asn Ser Ile Ser Asn Gln Ala Thr Lys Val Lys Val Cys 
65                  70                  75                  80  


Asp Asp Glu Ser Arg Leu Ile Lys Leu Ser Ile Ala Asp Thr Lys Lys 
                85                  90                  95      


Lys Pro Leu Trp Asp Phe Ile Val Asp Tyr Ala Asn Ser Asp Lys Asn 
            100                 105                 110         


Gly Gln Tyr Thr Ile Leu Arg Asn Ile Arg Lys Ser Ile Val Leu Phe 
        115                 120                 125             


Val Cys Gly Val Asp Val Tyr Arg Asn Ile Glu Asn Asn Asp Asn Leu 
    130                 135                 140                 


Asp Ile Trp Lys Trp Glu Glu Tyr Gly Ile Gln Glu Ser Gln Leu Phe 
145                 150                 155                 160 


Val Lys Ile Glu Asn Cys Tyr Thr Thr Lys Gly Glu Asp Ile Ala Leu 
                165                 170                 175     


Asn Glu Ile Arg Asn Val Asn Leu Asp His Tyr Met Lys Ala Ile Gly 
            180                 185                 190         


Val Leu Asp Asp Glu Arg Ser Lys Phe Trp Phe Gln His Tyr Glu Asn 
        195                 200                 205             


Thr Ile Glu Ala Leu Phe Ser Lys Lys Ser Lys Arg Lys Ile Glu Arg 
    210                 215                 220                 


Ile Lys Thr Ala Tyr Leu Cys Glu Tyr Leu Trp Lys Asn Phe Cys Ser 
225                 230                 235                 240 


Tyr Val Ala Leu Lys Tyr Val Asp Leu Gly Lys Gly Val Tyr His Phe 
                245                 250                 255     


Thr Met Ser Asp Lys Leu Ser Leu Met Asn Lys Asn Thr Asn Glu Asn 
            260                 265                 270         


Gly Ile Lys Phe Gly Glu Val Asp Ser Arg Phe Asn Lys Gly Ile Ser 
        275                 280                 285             


Ser Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Thr Ile Asp Arg Asn 
    290                 295                 300                 


Ile Ser Thr Tyr Thr Thr Phe Ala Thr Asn Ile Phe Ala Lys Ser Val 
305                 310                 315                 320 


Ile Lys Asp Ser Tyr Arg Gln Lys Lys Ala Gly Asn Ser Asp Ala Leu 
                325                 330                 335     


Gln Tyr Asp Asp Glu Thr Tyr Tyr Asn Arg Lys Ala Met Asn Pro Tyr 
            340                 345                 350         


Ala Leu Lys Arg Val Leu Arg Tyr Trp Gly Gly Gln Ser Arg Trp Lys 
        355                 360                 365             


Ser Glu Leu Glu Glu Leu Asn Val Ala Glu Leu Cys Ile Asp Ile Lys 
    370                 375                 380                 


Asn Arg Leu Ser Lys Ile Arg Asn Ser Gly Val His Tyr Thr Ser Thr 
385                 390                 395                 400 


Ser Ala Leu Lys Gly Asn Asp Asp Asp Ser Ile Val Gly Met Leu Ile 
                405                 410                 415     


Lys Lys Asp Phe Asp Asp Ile Lys Asp Val Tyr Ala Ser Lys Tyr Tyr 
            420                 425                 430         


Ser Asn Asn Val Trp Met Phe Tyr Asn Thr Asp Lys Ile Ser Lys Met 
        435                 440                 445             


Met Glu Tyr Leu Tyr Gln Asp Asp Ser Asn Ile Arg Asp Ala Gln Ile 
    450                 455                 460                 


Pro Ala Phe Asn Ser Val Ile Lys Arg Lys Asp Met Ala Glu Val Ile 
465                 470                 475                 480 


Glu Lys Ile Val Lys Lys Asn Ser Tyr Lys Thr Ile Lys Glu Pro Tyr 
                485                 490                 495     


Gln Arg Glu Lys Tyr Arg Ser Cys Leu Tyr Phe Met Leu Lys Glu Ile 
            500                 505                 510         


Tyr Tyr Asn Arg Phe Ile Lys Gln Asp Asn Leu Lys Asp Gln Val Ile 
        515                 520                 525             


Gln Ile Ile Asp Ser Asn Thr Glu Leu Ile Gly Asp Asn Ser Arg Ala 
    530                 535                 540                 


Val Asp Asn Leu Lys Lys Arg Ile His Asp Val Asp Ser Gln Thr Met 
545                 550                 555                 560 


Ser Phe Gly Glu Leu Cys Gln Val Ile Met Thr Asp Tyr Asn Met Gln 
                565                 570                 575     


Asn Gln Glu Asn Lys Ser Ile Lys Ser Lys Glu Arg Gln Asp Lys Asp 
            580                 585                 590         


Arg Lys Asn Gly Ile Asp Asn Ser Tyr Lys His Phe Pro Leu Leu Leu 
        595                 600                 605             


His His Leu Ile Lys Val Ser Phe Leu Lys Phe Ile Lys Thr Asp Glu 
    610                 615                 620                 


Lys Leu Ala Phe Ile Arg Glu Pro Arg Ile Thr Glu Trp Asp Lys Thr 
625                 630                 635                 640 


Leu Glu Gln Phe Glu Ala Gln Ile Gln Thr Val Asp Ile Tyr Asn Ser 
                645                 650                 655     


Leu Lys Met Met Val Ala Glu Asn Lys Ser Leu Leu Asp Trp Tyr Thr 
            660                 665                 670         


Leu Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asp 
        675                 680                 685             


Val Lys Asn Tyr Ile Gln Tyr Leu Ser Asn Ile Asp Lys Arg Ala Gly 
    690                 695                 700                 


Ser Val Lys Asn Asn Lys Ser Ala Ser Thr Glu Val Lys Ile Arg Gln 
705                 710                 715                 720 


Tyr Ser Glu Ile Val Arg Ile Leu Asp Phe Ser Leu Gln Tyr Ile Gly 
                725                 730                 735     


Arg Val Ser Asn Asp Val Thr Asp Tyr Phe Val Asp Glu Asp Glu Tyr 
            740                 745                 750         


Ala Ala Phe Leu Ser Lys Tyr Val Glu Phe Ser Gly Asn Asp Ile Val 
        755                 760                 765             


Ser Met Lys Ala Phe Cys Gln Ser Arg Thr Ala Asn Gly Lys His Thr 
    770                 775                 780                 


Ile Gly Leu Tyr Cys Asp Gly Ala Asn Pro Ile Met Asn Arg Asn Ile 
785                 790                 795                 800 


Ala Tyr Ala Lys Met Tyr Gly Asn Asp Glu Ile Leu Ser Tyr Ile Tyr 
                805                 810                 815     


Asn Lys Val Thr Lys Lys Asp Ile Glu Lys Tyr Tyr Val Ser Gln Asp 
            820                 825                 830         


Asn Leu Glu Lys Val Phe Ala Asp Gly Lys Cys Gln Asp Val Gln Gln 
        835                 840                 845             


Gln Asn Ala Leu Cys Asp Phe Gln Lys Met Lys Asn His Ile Glu Leu 
    850                 855                 860                 


Thr Glu Val Ser Ile Tyr Thr Asp Ile Leu Asn Asp Phe Met Ala Gln 
865                 870                 875                 880 


Phe Ile Ser Trp Ala Tyr Leu Arg Glu Arg Asp Leu Met Tyr Phe Gln 
                885                 890                 895     


Leu Gly Leu Asn Tyr Ile Arg Met Phe Tyr Gly Thr Tyr Glu Leu Glu 
            900                 905                 910         


Glu Lys Tyr Tyr Lys Leu His Gly Glu Asn Ile Asn Ile Glu Lys Gly 
        915                 920                 925             


Ala Leu Leu Tyr Gln Ile Val Ala Met Tyr Ser His Glu Leu Pro Ile 
    930                 935                 940                 


Tyr Lys Val Asp Glu Ser Gly Ile Ala Ile Leu Ala Glu Lys Gln Gly 
945                 950                 955                 960 


Ser Ser Gly Ala Ser Ile Lys Ser Phe Val Thr Glu Tyr Cys Lys Glu 
                965                 970                 975     


Glu Met Lys Lys Ala Tyr Thr Tyr Glu Asn Gly Leu Glu Leu Phe Glu 
            980                 985                 990         


Asp Val Asn Gln His Asp Asp Leu  Ser Lys Leu Arg Asn  Asp Phe Ala 
        995                 1000                 1005             


His Met  Arg Tyr Met Ser Ala  Arg Asp Lys Ser Ile  Met Asp Ile 
    1010                 1015                 1020             


Val Ser  Glu Ile Tyr Asn Gly  Phe Phe Ile Tyr Asp  Thr Lys Leu 
    1025                 1030                 1035             


Lys Lys  Ser Val Ser Phe Ile  Phe Lys Asn Ile Leu  Met Arg Tyr 
    1040                 1045                 1050             


Ala Val  Asp Val Asn Ile Glu  Phe Cys His Lys Gly  Asp Asn Glu 
    1055                 1060                 1065             


Asp Thr  Asn Asn Leu Ile Arg  Ile Lys Asp Glu Val  Gly Leu Tyr 
    1070                 1075                 1080             


Ser Asp  Lys Tyr Thr Tyr Lys  Val Glu Asp Asn Asp  Thr Val Asp 
    1085                 1090                 1095             


Ile Glu  Val Arg Asn Ser Glu  Phe Leu Glu Gln Leu  Lys Lys Leu 
    1100                 1105                 1110             


Leu Glu  Tyr Lys Lys Glu Ser  Glu Gly Ser Glu Leu  
    1115                 1120                 1125 


<210>  994
<211>  1125
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  994

Leu Lys Arg Thr Tyr Arg Phe Glu Thr Asn Tyr Gly Glu Lys Asn Thr 
1               5                   10                  15      


Phe Asn Leu Pro Asp Leu Val Lys Lys Ser Ile Lys Ile Tyr Cys Thr 
            20                  25                  30          


Asp Glu Lys Arg Lys Leu Asn Asp Arg Glu Glu Gln Glu Met Tyr Val 
        35                  40                  45              


Leu Phe Ser Tyr Met Tyr Glu Asp Lys Tyr Lys Asp Arg Gln Lys Val 
    50                  55                  60                  


Leu Ile Ala Asn Ser Ile Ser Asn Gln Ala Thr Lys Val Lys Val Cys 
65                  70                  75                  80  


Asp Asp Glu Ser Arg Leu Ile Lys Leu Ser Ile Ala Asp Thr Lys Lys 
                85                  90                  95      


Lys Pro Leu Trp Asp Phe Ile Val Asp Tyr Ala Asn Ser Asp Lys Asn 
            100                 105                 110         


Gly Gln Tyr Thr Ile Leu Arg Asn Ile Arg Lys Ser Ile Val Leu Phe 
        115                 120                 125             


Val Cys Gly Val Asp Val Tyr Arg Asn Ile Glu Asn Asn Asp Asn Leu 
    130                 135                 140                 


Asp Ile Trp Lys Trp Glu Glu Tyr Gly Ile Gln Glu Ser Gln Leu Phe 
145                 150                 155                 160 


Val Lys Ile Glu Asn Cys Tyr Thr Thr Lys Gly Glu Asp Ile Ala Leu 
                165                 170                 175     


Asn Glu Ile Arg Asn Val Asn Leu Asp His Tyr Met Lys Ala Ile Gly 
            180                 185                 190         


Val Leu Asp Asp Glu Arg Ser Lys Phe Trp Phe Gln His Tyr Glu Asn 
        195                 200                 205             


Thr Ile Glu Ala Leu Phe Ser Lys Lys Ser Lys Arg Lys Ile Glu Arg 
    210                 215                 220                 


Ile Lys Thr Ala Tyr Leu Cys Glu Tyr Leu Trp Lys Asn Phe Cys Ser 
225                 230                 235                 240 


Tyr Val Ala Leu Lys Tyr Val Asp Leu Gly Lys Gly Val Tyr His Phe 
                245                 250                 255     


Thr Met Ser Asp Lys Leu Ser Leu Met Asn Lys Asn Thr Asn Glu Asn 
            260                 265                 270         


Gly Ile Lys Phe Gly Glu Val Asp Ser Arg Phe Asn Lys Gly Ile Ser 
        275                 280                 285             


Ser Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Thr Ile Asp Arg Asn 
    290                 295                 300                 


Ile Ser Thr Tyr Thr Thr Phe Ala Thr Asn Ile Phe Ala Lys Ser Val 
305                 310                 315                 320 


Ile Lys Asp Ser Tyr Arg Gln Lys Lys Ala Gly Asn Ser Asp Ala Leu 
                325                 330                 335     


Gln Tyr Asp Asp Glu Thr Tyr Tyr Asn Arg Lys Ala Met Asn Pro Tyr 
            340                 345                 350         


Ala Leu Lys Arg Val Leu Arg Tyr Trp Gly Gly Gln Ser Arg Trp Lys 
        355                 360                 365             


Ser Glu Leu Glu Glu Leu Asn Val Ala Glu Leu Cys Ile Asp Ile Lys 
    370                 375                 380                 


Asn Arg Leu Ser Lys Ile Arg Asn Ser Gly Val His Tyr Thr Ser Thr 
385                 390                 395                 400 


Ser Ala Leu Lys Gly Asn Asp Asp Asp Ser Ile Val Gly Met Leu Ile 
                405                 410                 415     


Lys Lys Asp Phe Asp Asp Ile Lys Asp Val Tyr Ala Ser Lys Tyr Tyr 
            420                 425                 430         


Ser Asn Asn Val Trp Met Phe Tyr Asn Thr Asp Lys Ile Ser Lys Met 
        435                 440                 445             


Met Glu Tyr Leu Tyr Gln Asp Asp Ser Asn Ile Arg Asp Ala Gln Ile 
    450                 455                 460                 


Pro Ala Phe Asn Ser Val Ile Lys Arg Lys Asp Met Ala Glu Val Ile 
465                 470                 475                 480 


Glu Lys Ile Val Lys Lys Asn Ser Tyr Lys Thr Ile Lys Glu Pro Tyr 
                485                 490                 495     


Gln Arg Glu Lys Tyr Arg Ser Cys Leu Tyr Phe Met Leu Lys Glu Ile 
            500                 505                 510         


Tyr Tyr Asn Arg Phe Ile Lys Gln Asp Asn Leu Lys Asp Gln Val Ile 
        515                 520                 525             


Gln Ile Ile Asp Ser Asn Thr Glu Leu Ile Gly Asp Asn Ser Arg Ala 
    530                 535                 540                 


Val Asp Asn Leu Lys Lys Arg Ile His Asp Val Asp Ser Gln Thr Met 
545                 550                 555                 560 


Ser Phe Gly Glu Leu Cys Gln Val Ile Met Thr Asp Tyr Asn Met Gln 
                565                 570                 575     


Asn Gln Glu Asn Lys Ser Ile Lys Ser Lys Glu Arg Gln Asp Lys Asp 
            580                 585                 590         


Arg Lys Asn Gly Ile Asp Asn Ser Tyr Lys His Phe Pro Leu Leu Leu 
        595                 600                 605             


His His Leu Ile Lys Val Ser Phe Leu Lys Phe Ile Lys Thr Asp Glu 
    610                 615                 620                 


Lys Leu Ala Phe Ile Arg Glu Pro Arg Ile Thr Glu Trp Asp Lys Thr 
625                 630                 635                 640 


Leu Glu Gln Phe Glu Ala Gln Ile Gln Thr Val Asp Ile Tyr Asn Ser 
                645                 650                 655     


Leu Lys Met Met Val Ala Glu Asn Lys Ser Leu Leu Asp Trp Tyr Thr 
            660                 665                 670         


Leu Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asp 
        675                 680                 685             


Val Lys Asn Tyr Ile Gln Tyr Leu Ser Asn Ile Asp Lys Arg Ala Gly 
    690                 695                 700                 


Ser Val Lys Asn Asn Lys Ser Ala Ser Thr Glu Val Lys Ile Arg Gln 
705                 710                 715                 720 


Tyr Ser Glu Ile Val Arg Ile Leu Asp Phe Ser Leu Gln Tyr Ile Gly 
                725                 730                 735     


Arg Val Ser Asn Asp Val Thr Asp Tyr Phe Val Asp Glu Asp Glu Tyr 
            740                 745                 750         


Ala Ala Phe Leu Ser Lys Tyr Val Glu Phe Ser Gly Asn Asp Ile Val 
        755                 760                 765             


Ser Met Lys Ala Phe Cys Gln Ser Arg Thr Ala Asn Gly Lys His Thr 
    770                 775                 780                 


Ile Gly Leu Tyr Cys Asp Gly Ala Asn Pro Ile Met Asn Arg Asn Ile 
785                 790                 795                 800 


Ala Tyr Ala Lys Met Tyr Gly Asn Asp Glu Ile Leu Ser Tyr Ile Tyr 
                805                 810                 815     


Asn Lys Val Thr Lys Lys Asp Ile Glu Lys Tyr Tyr Val Ser Gln Asp 
            820                 825                 830         


Asn Leu Glu Lys Val Phe Ala Asp Gly Lys Cys Gln Asp Val Gln Gln 
        835                 840                 845             


Gln Asn Ala Leu Cys Asp Phe Gln Lys Met Lys Asn His Ile Glu Leu 
    850                 855                 860                 


Thr Glu Val Ser Ile Tyr Thr Asp Ile Leu Asn Asp Phe Met Ala Gln 
865                 870                 875                 880 


Phe Ile Ser Trp Ala Tyr Leu Arg Glu Arg Asp Leu Met Tyr Phe Gln 
                885                 890                 895     


Leu Gly Leu Asn Tyr Ile Arg Met Phe Tyr Gly Thr Tyr Glu Leu Glu 
            900                 905                 910         


Glu Lys Tyr Tyr Lys Leu His Gly Glu Asn Ile Asn Ile Glu Lys Gly 
        915                 920                 925             


Ala Leu Leu Tyr Gln Ile Val Ala Met Tyr Ser His Glu Leu Pro Ile 
    930                 935                 940                 


Tyr Lys Val Asp Glu Ser Gly Ile Ala Ile Leu Ala Glu Lys Gln Gly 
945                 950                 955                 960 


Ser Ser Gly Ala Ser Ile Lys Ser Phe Val Thr Glu Tyr Cys Lys Glu 
                965                 970                 975     


Glu Met Lys Lys Ala Tyr Thr Tyr Glu Asn Gly Leu Glu Leu Phe Glu 
            980                 985                 990         


Asp Val Asn Gln His Asp Asp Leu  Ser Lys Leu Arg Asn  Asp Phe Ala 
        995                 1000                 1005             


His Met  Arg Tyr Met Ser Ala  Arg Asp Lys Ser Ile  Met Asp Ile 
    1010                 1015                 1020             


Val Ser  Glu Ile Tyr Asn Gly  Phe Phe Ile Tyr Asp  Thr Lys Leu 
    1025                 1030                 1035             


Lys Lys  Ser Val Ser Phe Ile  Phe Lys Asn Ile Leu  Met Arg Tyr 
    1040                 1045                 1050             


Ala Val  Asp Val Asn Ile Glu  Phe Cys His Lys Gly  Asp Asn Glu 
    1055                 1060                 1065             


Asp Thr  Asn Asn Leu Ile Arg  Ile Lys Asp Glu Val  Gly Leu Tyr 
    1070                 1075                 1080             


Ser Asp  Lys Tyr Thr Tyr Lys  Val Glu Asp Asn Asp  Thr Val Asp 
    1085                 1090                 1095             


Ile Glu  Val Arg Asn Ser Glu  Phe Leu Glu Gln Leu  Lys Lys Leu 
    1100                 1105                 1110             


Leu Glu  Tyr Lys Lys Glu Ser  Glu Gly Ser Glu Leu  
    1115                 1120                 1125 


<210>  995
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  995

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Gly Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  996
<211>  1152
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  996

Met Leu Arg Arg Met Cys Met Lys Ile Thr Lys Ile Asp Gly Ile Ser 
1               5                   10                  15      


His Lys Lys Tyr Lys Glu Lys Gly Lys Leu Ile Lys Asn Asn Asp Thr 
            20                  25                  30          


Ala Lys Asp Ile Ile Glu Glu Arg Phe Asn Asp Ile Glu Lys Lys Thr 
        35                  40                  45              


Lys Glu Leu Phe Gln Lys Thr Leu Asp Phe Tyr Val Lys Asn Tyr Glu 
    50                  55                  60                  


Lys Cys Lys Glu Gln Asn Lys Glu Arg Arg Glu Lys Ala Lys Asn Tyr 
65                  70                  75                  80  


Phe Ser Lys Val Lys Ile Leu Val Asp Asn Lys Lys Ile Thr Ile Cys 
                85                  90                  95      


Asn Glu Asn Thr Glu Lys Met Glu Ile Glu Asp Phe Asn Glu Tyr Asp 
            100                 105                 110         


Val Lys Ser Gly Lys Tyr Phe Asn Val Leu Asn Lys Ile Leu Asn Gly 
        115                 120                 125             


Glu Asn Tyr Thr Glu Glu Asp Leu Glu Val Phe Glu Asn Asp Leu Gln 
    130                 135                 140                 


Lys Arg Ile Gly Arg Ile Lys Ser Ile Lys Asn Ser Leu Glu Glu Asn 
145                 150                 155                 160 


Lys Ala His Phe Lys Lys Glu Ser Ile Asn Asn Asn Ile Ile Tyr Asp 
                165                 170                 175     


Arg Val Lys Gly Asn Asn Lys Lys Ser Leu Phe Tyr Glu Tyr Tyr Arg 
            180                 185                 190         


Ile Ser Ser Lys His Gln Glu Tyr Val Asn Asn Ile Phe Glu Ala Phe 
        195                 200                 205             


Asp Lys Leu Tyr Ser Asn Ser His Glu Ala Met Asn Asn Leu Phe Ser 
    210                 215                 220                 


Glu Ile Thr Lys Asp Ser Lys Asp Arg Asn Ile Arg Lys Ile Arg Gly 
225                 230                 235                 240 


Ala Tyr His Glu Ile Leu Asn Lys Asn Lys Thr Glu Phe Gly Glu Glu 
                245                 250                 255     


Leu Tyr Lys Lys Ile Gln Asp Asn Arg Asn Asn Phe Asn Lys Leu Leu 
            260                 265                 270         


Glu Ile Glu Pro Glu Ile Lys Glu Leu Thr Lys Ser Gln Ile Phe Tyr 
        275                 280                 285             


Lys Tyr Tyr Ile Asp Lys Val Asn Leu Asp Glu Thr Ser Ile Lys His 
    290                 295                 300                 


Cys Phe Cys His Leu Val Glu Ile Glu Val Asn Gln Leu Leu Lys Asn 
305                 310                 315                 320 


Tyr Val Tyr Ser Lys Arg Asn Ile Asn Lys Glu Lys Leu Glu Asn Ile 
                325                 330                 335     


Phe Glu Tyr Cys Lys Leu Arg Asn Leu Val Lys Asn Lys Leu Val Asn 
            340                 345                 350         


Lys Leu Asn Asn Tyr Ile Arg Asn Cys Gly Lys Tyr Asn Ala Tyr Ile 
        355                 360                 365             


Ser Asn Asn Asp Val Val Val Asn Ser Glu Lys Ile Ser Glu Ile Arg 
    370                 375                 380                 


Thr Lys Glu Ala Phe Leu Arg Ser Ile Ile Gly Val Ser Ser Ser Ala 
385                 390                 395                 400 


Tyr Phe Ser Leu Arg Asn Ile Leu Asn Ser Asn Asn Thr Gln Asp Ile 
                405                 410                 415     


Thr Asn Asp Arg Ile Leu Lys Gln Glu Leu Asp Asp Ile Tyr Gln Glu 
            420                 425                 430         


Asn Asn Lys Lys Asn Lys Leu Glu Lys Asn Leu Lys Leu Phe Phe Gly 
        435                 440                 445             


Asn Tyr Phe Asp Val Met Arg Glu Ser Glu Ile Arg Glu Phe Phe Thr 
    450                 455                 460                 


Asn Ile Arg Asp Ile Ile Lys Arg Ile Arg Asn Lys Ile Ile His Phe 
465                 470                 475                 480 


Glu Met Glu Ala Asn Ala Gln Asn Ile Phe Asp Phe Asn Asn Ile Asn 
                485                 490                 495     


Leu Gly Asn Thr Ala Lys Asn Ile Phe Asn Asn Glu Ile Asn Glu Glu 
            500                 505                 510         


Lys Ile Lys Phe Lys Ile Phe Lys Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Asp Tyr Leu Ser Asn Lys Asp Ile Arg Glu Tyr Met Gly Lys Asp Val 
    530                 535                 540                 


Phe Ser Phe Ile Asn Arg Asn Ile Ser Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Ile Tyr Asn Arg Val Gln Asp Leu Ala Asn Ser Leu Glu Ile Lys Glu 
                565                 570                 575     


Trp Lys Ile Pro Asp Glu Ser Glu Gly Lys Asp Val Gln Ile Tyr Leu 
            580                 585                 590         


Leu Lys Asn Ile Tyr Tyr Gly Lys Phe Leu Asp Lys Phe Leu Asn Glu 
        595                 600                 605             


Glu Asn Gly Ile Phe Ile Ser Ile Lys Asp Lys Ile Ile Glu Leu Asn 
    610                 615                 620                 


Arg Asn Gln Asn Lys Arg Thr Gly Phe Tyr Lys Leu Glu Lys Phe Glu 
625                 630                 635                 640 


Lys Ile Glu Glu Thr Asn Pro Lys Lys Tyr Leu Glu Ile Ile Gln Ser 
                645                 650                 655     


Leu Tyr Met Ile Asn Ile Glu Glu Ile Asp Ser Glu Gly Lys Asn Ile 
            660                 665                 670         


Phe Leu Asp Phe Ile Gln Lys Ile Phe Leu Lys Gly Phe Phe Glu Phe 
        675                 680                 685             


Ile Lys Asn Asp Tyr Asn Tyr Leu Leu Glu Leu Lys Lys Val Gln Asp 
    690                 695                 700                 


Lys Lys Asn Ile Phe Asp Ser Lys Met Leu Glu Tyr Ile Thr Gly Glu 
705                 710                 715                 720 


Lys Thr Leu Glu Asp Met Glu Glu Ile Asn Glu Ile Ile Gln Asp Ile 
                725                 730                 735     


Lys Ile Thr Glu Ile Asp Lys Ile Leu Asn Gln Thr Asp Lys Ile Asn 
            740                 745                 750         


Cys Phe Tyr Leu Leu Leu Lys Leu Leu Asn Tyr Lys Glu Ile Thr Glu 
        755                 760                 765             


Leu Lys Gly Asn Leu Glu Lys Tyr Gln Ile Leu Ser Lys Thr Asn Val 
    770                 775                 780                 


Tyr Glu Lys Glu Leu Met Leu Leu Asn Ile Val Asn Leu Asp Asn Asn 
785                 790                 795                 800 


Lys Val Lys Ile Glu Asn Phe Lys Ile Ser Ala Glu Glu Ile Gly Lys 
                805                 810                 815     


Phe Ile Glu Lys Ile Asn Ile Glu Glu Ile Asn Lys Asn Lys Lys Ile 
            820                 825                 830         


Lys Thr Phe Glu Glu Leu Arg Asn Phe Glu Lys Gly Glu Asn Thr Gly 
        835                 840                 845             


Glu Tyr Tyr Asn Ile Tyr Ser Asp Asp Lys Asn Ile Lys Asn Ile Arg 
    850                 855                 860                 


Asn Leu Tyr Asn Ile Lys Lys Tyr Gly Met Leu Asp Leu Leu Glu Lys 
865                 870                 875                 880 


Ile Ser Glu Lys Ile Asn Tyr Cys Ile Lys Lys Lys Asp Leu Glu Glu 
                885                 890                 895     


Tyr Ser Lys Leu Arg Lys Gln Leu Glu Asp Glu Lys Thr Asp Phe Tyr 
            900                 905                 910         


Lys Ile Gln Lys Tyr Leu His Ser Lys Tyr Gln Gln Lys Pro Lys Lys 
        915                 920                 925             


Ile Leu Trp Lys Asn Asn Lys Asn Asp Tyr Glu Lys Tyr Lys Lys Ser 
    930                 935                 940                 


Ile Glu Asn Ile Glu Lys Tyr Val His Leu Lys Asn Lys Ile Glu Phe 
945                 950                 955                 960 


Asn Glu Leu Asn Leu Leu Gln Ser Leu Leu Leu Lys Ile Leu His Arg 
                965                 970                 975     


Leu Val Gly Phe Thr Ser Ile Trp Glu Arg Asp Leu Arg Phe Arg Leu 
            980                 985                 990         


Thr Gly Glu Phe Ser Asp Glu Leu  Asp Val Glu Asp Ile  Phe Asp His 
        995                 1000                 1005             


Arg Lys  Arg Tyr Lys Gly Thr  Gly Gly Gly Ile Cys  Lys Lys Tyr 
    1010                 1015                 1020             


Asp Arg  Phe Ile Asn Thr Tyr  Thr Glu Tyr Lys Asn  Asn Asn Lys 
    1025                 1030                 1035             


Met Lys  Asn Val Lys Phe Asp  Asp Asn Thr Pro Val  Arg Asn Tyr 
    1040                 1045                 1050             


Ile Ala  His Phe Asn Tyr Leu  Pro Asn Pro Lys Tyr  Ser Ile Leu 
    1055                 1060                 1065             


Lys Met  Met Glu Lys Leu Arg  Lys Leu Leu Asp Tyr  Asp Arg Lys 
    1070                 1075                 1080             


Leu Lys  Asn Ala Val Met Lys  Ser Ile Lys Asp Ile  Leu Glu Glu 
    1085                 1090                 1095             


Tyr Gly  Phe Lys Ala Glu Phe  Ile Ile Asn Ser Asp  Lys Glu Ile 
    1100                 1105                 1110             


Ile Leu  Asn Leu Val Lys Ser  Val Glu Ile Ile His  Leu Gly Lys 
    1115                 1120                 1125             


Glu Asp  Leu Lys Ser His Arg  Asn Ser Glu Asp Leu  Cys Lys Leu 
    1130                 1135                 1140             


Val Lys  Ala Met Leu Glu Tyr  Ser Lys 
    1145                 1150         


<210>  997
<211>  1315
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  997

Met Ile Ile Ile Lys Lys Phe Gly Arg Ser Val Ile Thr Gln Asp Lys 
1               5                   10                  15      


Asn Thr Asp Asn Lys Arg Glu Arg Glu Leu Asp Thr Ser Ala Arg Ala 
            20                  25                  30          


Lys Ala Lys Ser Gln Asn Ser Gln Val Phe Pro Phe Leu Asn Lys Lys 
        35                  40                  45              


Glu Asp Phe Ile Asn Leu Trp Ile Ser Glu Phe Asp Lys Leu Ile Tyr 
    50                  55                  60                  


Lys Pro Lys Gly Asp Asp Lys Pro Thr Lys Glu Met Tyr Thr Leu Arg 
65                  70                  75                  80  


Glu Ala Ala Gly Lys Gly Phe Leu Asn Tyr Trp Asn Gln Met Pro Met 
                85                  90                  95      


Val Ser Lys Lys Asp Gly Ala Phe Ser Asp Met Trp Met Ser Lys Val 
            100                 105                 110         


His Pro Tyr Gly Arg Gly Ile Thr Glu Phe Ser Pro Pro Leu Gln Leu 
        115                 120                 125             


Glu Lys Leu Ile Asp Gln Gly Leu Leu Ser Ala Met Gly Gly Ser Glu 
    130                 135                 140                 


Pro Leu Lys Asn Cys His Trp Asn Arg Val Thr Ser Asn Val Phe Lys 
145                 150                 155                 160 


Gly Leu Lys Val Gln Leu Asp Ile Leu Glu Ala Gln Ala Lys Asn Thr 
                165                 170                 175     


Phe Val Ile Lys Asn Lys Thr Asn Ser Lys Arg Asn Arg Pro Ala Ser 
            180                 185                 190         


Gln Asn Ile Lys Glu Phe Leu Leu Thr Asp Glu Thr Ala Phe Ile Asn 
        195                 200                 205             


Leu Trp Ile Ser Glu Phe Asp Lys Leu Ile Leu Lys Pro Gln Gly His 
    210                 215                 220                 


Asn Lys Pro Thr Glu Lys Met Tyr Asn Leu Arg Gln Gln Ala Gly Val 
225                 230                 235                 240 


Ala Phe Leu Asn Tyr Trp Lys Lys Lys Pro Leu Ile Pro Trp Ala Asn 
                245                 250                 255     


Ser Glu Ser Phe Pro Asp Lys Trp Met Leu Lys Val His Pro Tyr Gly 
            260                 265                 270         


Asp Lys Thr Ser Asn Asn Arg Ser Glu Thr Leu Ile Lys Ser Lys Trp 
        275                 280                 285             


Gly Ser Val Met Arg Ala Lys Glu Cys Leu Ser Asp Asp Gln Trp Glu 
    290                 295                 300                 


Gln Val Ala Phe Asn Val Tyr Ser His Leu Tyr Gly Asn Gln Lys Thr 
305                 310                 315                 320 


Leu Asn Gly Lys Asn Lys Glu Ile Gly Leu Ile Ala Ala Arg Ala Asn 
                325                 330                 335     


Ser Ile Lys Gln Asn Val Pro Ser Tyr Thr Leu Asp Lys Asp Asn Asn 
            340                 345                 350         


Phe Leu Ser Asp Lys Lys Asp Lys Leu Arg Tyr Ile Ala Ala Leu Arg 
        355                 360                 365             


Gly Glu Gly Ile Lys Trp Glu Glu Val Lys Asp Arg Tyr Lys Trp Lys 
    370                 375                 380                 


Glu Leu Thr Gln Leu Ile Asn Ile Glu Glu Ile Asp Ser Thr Asp Ile 
385                 390                 395                 400 


Ala Lys Arg Lys Gln His Leu Ala Glu Cys Phe Tyr Thr His His Gly 
                405                 410                 415     


Arg Ile Phe Gly Asp Ile Gln Asn Ser Lys Ile Glu Asp Lys Asp Cys 
            420                 425                 430         


Phe Leu Tyr His Ser Leu Val Lys Glu Ile Leu Phe Glu Cys Ile Glu 
        435                 440                 445             


Lys Lys Gln Asp Phe Leu Asn Asp Thr Glu Val His Gln Arg Leu Ile 
    450                 455                 460                 


Tyr Lys Glu Asn Asn Arg Ile Met Ala Thr Ala Val Ser Ile Gly Lys 
465                 470                 475                 480 


Leu Ile His Tyr Gln Gly Gly Ile Glu Ala Ile Gly Asn Lys Glu Asp 
                485                 490                 495     


Leu Val Asn Ser Lys Phe Leu Thr Asp Ala Gly Leu Thr Glu Ile Lys 
            500                 505                 510         


Gln Asn Glu Ser Phe Val Arg Gln Trp Leu Glu Leu Ile Ala Ile Ala 
        515                 520                 525             


Asn Thr Thr Leu Ser Gln Leu Val Asp Pro Asp Gly Lys His Glu Asp 
    530                 535                 540                 


Ile Phe Ala Ala Thr Ser Phe Asp Asp Ala Leu Lys Gly Leu Asn Asn 
545                 550                 555                 560 


Ile Ser Asp Phe Asp Ser Lys Phe Lys Leu Leu Phe Gly Glu Asn His 
                565                 570                 575     


Arg Leu Tyr Asp Asp Asp Thr Glu Arg Gln Lys Leu Leu Arg Ile Ile 
            580                 585                 590         


Tyr Asp Thr Ile Ser Ala Leu Arg Asn Ala Ser Phe His Phe Lys Asn 
        595                 600                 605             


Ile Gln Gly Phe Asn Lys Ala Leu Glu Asp Asn Leu Ser Thr Lys Gly 
    610                 615                 620                 


Arg Arg Gln Lys Gly Val Val Asp Lys Ile Ile Glu Tyr Thr Lys Val 
625                 630                 635                 640 


His Gln Gln Lys Gln His Glu Leu Leu Ile Ala Asp Leu Lys Ala Ala 
                645                 650                 655     


Asn Val Glu Asp Tyr Leu Ser Gln Leu Gln Leu Asp Tyr Leu Phe Glu 
            660                 665                 670         


Val Val Cys Lys Gly Glu Arg Glu Leu Leu Asp Met Pro Lys Phe Ser 
        675                 680                 685             


Lys Leu Leu Leu Arg Ala Gly Glu Ile Gly Glu Lys Ile Ile Ser Pro 
    690                 695                 700                 


Val Asn Ala Thr Ala Met Glu His Pro Ala Tyr Gln Cys Cys Phe Ile 
705                 710                 715                 720 


Ser Leu Lys Met Leu Tyr Asp Gln Asp Phe Val Asn Trp Leu Lys Lys 
                725                 730                 735     


Gln Ser Asn Lys Asn Ile Ala Ser Trp Met Asp Ser Ala Lys Thr Arg 
            740                 745                 750         


Ala Thr Asn Ala Ala Lys Lys Ile Phe Arg Asn Gly Thr Asn Ile Ser 
        755                 760                 765             


Ser Lys Met Ala Arg Leu Arg Asn Ile Val Glu Asp Glu Thr Leu Val 
    770                 775                 780                 


Glu Tyr Phe Ser Phe Ile Thr Ala Glu Thr Ala Asn Glu Phe Gln Val 
785                 790                 795                 800 


Gln Gln Gln Lys Asn Arg Tyr Gln Ser Asn Ser Ala Ser Ala Lys Glu 
                805                 810                 815     


Gln Ser Asn Phe Val Glu Gln Phe Lys Gln Asp Phe Leu Ile Tyr Ala 
            820                 825                 830         


Phe Lys Gly Tyr Ile Gly Asp Ile Lys Phe Gly Lys Leu Asp Gln Gly 
        835                 840                 845             


Glu Lys Leu Leu Lys Cys Asn Ala Lys Gly Ser Leu Leu Pro Glu Asn 
    850                 855                 860                 


Asn Arg Ser Asp Thr Gly Ala Glu Asp Ile Glu Arg Pro Trp Leu Tyr 
865                 870                 875                 880 


Leu Val Leu His Leu Val Pro Ile Glu Val Val Asn Arg Ile Thr Leu 
                885                 890                 895     


Gln Ile Lys Lys His Ser Val Leu Thr Asn Ser Thr Leu Asp Asp Thr 
            900                 905                 910         


Arg Ala Ala Tyr Thr Asp Ile His Gln Ala Phe Ser Leu Tyr Leu Gly 
        915                 920                 925             


Val His Gly Ala Ile Leu Gly Leu Gln Ser Leu Ser Asn Glu Pro Glu 
    930                 935                 940                 


Leu Gln Val Phe Phe Glu Lys Glu Ser Asp Phe Asn Asn Leu Phe Thr 
945                 950                 955                 960 


Asp Asn Gly Glu Gly Leu Val Pro Val Lys Gly Leu Arg Asp Ile Leu 
                965                 970                 975     


Arg Phe Gly Asn Leu Glu Gln Leu Lys Lys Met Phe Ser Asp Lys Lys 
            980                 985                 990         


Val Ala Ser Asp Asp Ile Thr Asn  Leu Lys Glu Tyr Leu  Glu Ala Thr 
        995                 1000                 1005             


Gly Gly  Lys Ser Lys Ile Ala  Arg Ala Gln Glu Lys  Arg Ile Glu 
    1010                 1015                 1020             


Leu His  Lys Thr Leu Thr Glu  Leu Pro Lys Arg Leu  Thr Lys Pro 
    1025                 1030                 1035             


Arg Val  Lys Gln Thr Gly Ile  Asp Thr Tyr Glu Lys  Asn Asn Asn 
    1040                 1045                 1050             


Ile Ser  Ile Ser Gly Ser Ile  Ser Glu Tyr Arg Lys  Asp Leu Lys 
    1055                 1060                 1065             


Cys Ile  Val Ser Tyr Arg Glu  Leu Lys Asn Lys Ile  Tyr Leu Tyr 
    1070                 1075                 1080             


Asn Val  Lys Gln Ala His Gln  Leu Ile Met Ala Thr  Gln Ala Arg 
    1085                 1090                 1095             


Leu Leu  Gly Tyr Ser Gln Ile  Arg Glu Arg Asp Leu  Tyr Phe Val 
    1100                 1105                 1110             


Leu Leu  Thr Gln Leu Met Leu  Arg Gly Val Thr Leu  Glu Lys Glu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Asp Lys Asp  Lys Leu Asn Ala Leu  Asp Thr Asp 
    1130                 1135                 1140             


Thr Val  Leu Asp Glu Glu Glu  Lys Lys Lys Leu Glu  Lys Gln Ile 
    1145                 1150                 1155             


Lys Pro  Glu Arg Ser Leu Lys  Asp Leu Val Glu Lys  Gly Leu Ile 
    1160                 1165                 1170             


Phe Leu  Ala Leu Asp Gln Leu  Ser Ser Ser Asp Lys  Asp Leu Lys 
    1175                 1180                 1185             


Ala Ile  His Ser Glu Ile Glu  Asp Met Phe Val Gly  Val Ser Pro 
    1190                 1195                 1200             


Asp Ser  Asp Asn Arg Asn Leu  Arg Asn Arg Leu Ala  His Phe Lys 
    1205                 1210                 1215             


Asp Leu  Gly Asn Lys Asn Leu  Ile Asn Ile Thr Ser  Gln Ile Asn 
    1220                 1225                 1230             


Glu Val  Arg Lys Met Met Ser  Tyr Asp Arg Lys Leu  Lys Asn Ala 
    1235                 1240                 1245             


Val Ser  Lys Ser Met Ile Asp  Leu Phe Glu Arg Tyr  Asn Leu Ile 
    1250                 1255                 1260             


Leu Ser  Phe Lys Val Gln Ser  His Lys Leu Gln Leu  Lys Asn Leu 
    1265                 1270                 1275             


Lys Ser  Lys Gln Ile Thr His  Leu Asn Asn Lys Gly  Ile Thr Glu 
    1280                 1285                 1290             


Asn Leu  Leu Ser Asp Asp Tyr  Val Ser Val Ile Lys  Arg Leu Leu 
    1295                 1300                 1305             


Leu Thr  Glu Gln Asn Pro Glu  
    1310                 1315 


<210>  998
<211>  1373
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  998

Met Ala Lys His Leu Arg Pro Ile Gly Glu Ser Tyr Thr Asp Phe Leu 
1               5                   10                  15      


Asp Glu Thr Glu Phe Val Arg Leu Gly Arg Gly Leu His Arg Gly His 
            20                  25                  30          


His Gly Val Gln Ile Pro Pro Thr Glu Leu Pro Ser Tyr Leu Ala Glu 
        35                  40                  45              


Tyr Arg Lys Ala Leu Met Arg Gln Val Val Ala Val Leu Asp Lys Val 
    50                  55                  60                  


Val Gly Lys Arg Arg Arg Leu Ser Gly Met His Pro Glu Ala Tyr Arg 
65                  70                  75                  80  


Asp Arg Val His Leu Ala Glu Ala Leu Trp Val Arg Leu Val Ala Arg 
                85                  90                  95      


Val Lys Glu Ile Gly Thr Pro Pro Asp Pro Ser Glu Leu Leu Asp Leu 
            100                 105                 110         


Arg Arg Met Trp Asn Ala Lys Ala His Pro Tyr Ala Glu Tyr Asp Val 
        115                 120                 125             


Val Pro Arg Ala Pro Leu Asn Asp Gly Asn Gly Gln Lys Ile Leu Glu 
    130                 135                 140                 


Cys Arg Glu Val Asp Asp Pro Lys Ile Glu Arg Ser Asp Phe Glu Gly 
145                 150                 155                 160 


Arg Trp His Gly Arg Phe Trp Gln Ser Glu Pro Gly Pro Val Asp Tyr 
                165                 170                 175     


Asn Ala Ile Ala Asp Arg Ile Phe Ala His Leu Phe Asp Gln Glu Ala 
            180                 185                 190         


Val Ile Gly Gly Gly Pro Arg Arg Glu Gly Asn Val Thr Val Pro Asp 
        195                 200                 205             


Glu Asp Ile Asn Gly Gln Pro Gly Pro Ala Thr Gly Lys Gly Leu Ile 
    210                 215                 220                 


Ile Ala Arg Gly Gln Ser Ile Val Lys Ser Ala Ser Asp Pro Arg Arg 
225                 230                 235                 240 


Ser Ser Lys Lys Val Gln Arg Thr Trp Asp Lys Ala Val Glu Arg Arg 
                245                 250                 255     


Tyr Phe Gly Asp Asp Gly Lys Gly Gly Ser Asp Ile Ala Lys Ala Ile 
            260                 265                 270         


Tyr Glu Glu Leu Gly Asp Pro Ala Thr Leu Ala Asp Pro Ile Tyr Ala 
        275                 280                 285             


Ser Trp Phe Gly Ser Arg Leu Tyr Asp His Phe Gly Ser Phe Lys Asn 
    290                 295                 300                 


Ser Leu Pro Leu Glu Leu Lys Asp Pro Phe Lys Glu Gln Ile Trp Ala 
305                 310                 315                 320 


Leu His Asn Ser Val Arg Gln Phe Tyr Gln Arg Met Ala Lys Ser Asp 
                325                 330                 335     


Arg Phe Arg Leu Ala Leu Gln Asn Ala Arg Ser Glu Val Pro Asp Arg 
            340                 345                 350         


Ser Glu Leu Leu Ala Leu Leu Pro Lys Asp His Asp His Leu Leu Leu 
        355                 360                 365             


Val Leu Gly Gly Lys Lys Lys Asn Ala Glu Met Ser Glu Leu Ile Arg 
    370                 375                 380                 


Leu Gly Lys Leu Phe Val His Ala Ser Asp Val Leu His Asp Phe Asp 
385                 390                 395                 400 


Ala Asn Asp Ala Ala Ala Leu Asp Ala Phe Lys Arg Arg Met Ser Phe 
                405                 410                 415     


Leu Ala Thr Ser Ile Gly Gln Ser Glu Ile Lys Gln Thr Glu Thr Phe 
            420                 425                 430         


Ala Arg Thr Trp Arg Gly Ala Val Gly Leu Thr Leu Arg Thr Val Lys 
        435                 440                 445             


Gly Leu Ala Asp Pro Arg Gly Ile Ile Gly Thr Pro Asp Asn Arg Asp 
    450                 455                 460                 


Leu Gly Thr Ala Gly Pro Met Lys Asp Ala Phe Asn Lys Phe Asp Gln 
465                 470                 475                 480 


Pro His Phe Gln Gln His Met Thr Ile Ile Phe Gly Asn Lys Glu Leu 
                485                 490                 495     


Gln Ala Glu Gly Asn Pro Thr Arg Ser Ser Val Phe Thr Ala Asn Gly 
            500                 505                 510         


Asp Lys Asp His Gln Ala Glu Leu Leu Trp Gly Phe Leu Cys Val Val 
        515                 520                 525             


Arg Ser Val Arg Asn Arg Thr Asn His Tyr Asn Val Arg Arg Ala Leu 
    530                 535                 540                 


Phe Arg Leu Leu Asp Glu Gly Ile Val Ser Pro Met Pro Ser Asp Pro 
545                 550                 555                 560 


Lys Lys Glu Arg Val Glu Asn Arg Asn Leu Cys Thr Val Ser Pro Thr 
                565                 570                 575     


Ala Leu Glu Ala Phe Arg Arg Leu Leu Asn Phe Asp Leu Ala Ile Gln 
            580                 585                 590         


Lys Glu Ala Val Arg Thr Ala Leu Glu Gln Ala Lys Ala Ser Glu Phe 
        595                 600                 605             


Val Glu Glu Gly Lys Leu Arg Gly Leu Val Ser Glu Leu Ala Gly Thr 
    610                 615                 620                 


Glu Asp Met Pro Ala Leu His Ile Pro Arg Phe Ser Ala Val Met Asp 
625                 630                 635                 640 


Lys Val Arg Arg Leu Ala Asp Asn Arg Asp Val Gly Leu Asp Pro Ile 
                645                 650                 655     


Leu Ser Thr Leu Gln Arg Ser Leu Pro Pro Thr Asp Lys Gln Ala Glu 
            660                 665                 670         


Ser Asp Ala Ala Arg Cys Arg Tyr Arg Leu Leu Leu Glu Leu Tyr Lys 
        675                 680                 685             


Ser Gly Phe Arg Ser Trp Phe Ser Gly Ile Gln Ser Asn Glu Glu Asn 
    690                 695                 700                 


Asn Arg Glu Ile Cys His Trp Ala Val Lys Gln Val Gly Arg Ala Lys 
705                 710                 715                 720 


Asp Ala Arg Lys Ser Glu Tyr Asp Lys Lys Thr Lys Arg His Tyr Arg 
                725                 730                 735     


Ser Pro Asn Ser Leu Ile Asp Asp Leu Gly Leu Asp Lys Phe Asp Asp 
            740                 745                 750         


Leu Thr Asp Leu Leu Glu Ala Leu Ala Ser Gln Ser Thr Arg Glu His 
        755                 760                 765             


Asp Gln Asn Leu Lys Tyr Val Pro Asp Ala Arg Val Gln Ser Gln Met 
    770                 775                 780                 


Ser Asn Arg Ile Glu Glu Phe Arg Gln Glu Leu Phe Ala His Ile Phe 
785                 790                 795                 800 


Thr Lys Tyr Leu Asp Thr His Asp Phe Gly Trp Ile Gly Ala Ile Glu 
                805                 810                 815     


Val Arg Arg Glu Ala Cys Asp Leu Ala Asp Val Val Ser Ala Phe Glu 
            820                 825                 830         


Val Arg Asp Gln Lys Phe Asp Ala Asp Trp His Ser Gln Phe Tyr Ala 
        835                 840                 845             


Trp Leu Tyr Met Val Pro Pro Ile Glu Ala Ser Arg Leu Arg His Gln 
    850                 855                 860                 


Met Arg Lys Ser Ala Val Met Asp Asp Lys Trp Ser Thr Thr Leu Glu 
865                 870                 875                 880 


Leu Thr Ser Gly Asp Arg Lys Thr Arg Asp Asp His Ala Gln Asp Val 
                885                 890                 895     


Leu Ala Asp Met Asp Arg Leu Phe Ser Leu Tyr Thr Lys Val Gln Ala 
            900                 905                 910         


Ala Gly Phe Asn Gly Gln Glu His Glu Ser Ala Leu Gly Ser Lys Ser 
        915                 920                 925             


Leu Phe Tyr Glu Asp Gly Asn Gln Phe Asp Glu Val Tyr Ser Pro Asp 
    930                 935                 940                 


Thr Glu Thr His Asn Lys Thr Phe Pro Gly Thr Arg Arg Gly Leu Arg 
945                 950                 955                 960 


Gln Leu Val Arg Tyr Ala His Leu Pro Ala Leu Glu Gly Val Phe Lys 
                965                 970                 975     


Lys His Arg Ile Thr Lys Ala Glu Val Glu Thr Phe Val Ala Leu Tyr 
            980                 985                 990         


Asp Glu Asn Arg Arg Asp Pro Gly  Ser Val Ala His Met  Leu Arg Arg 
        995                 1000                 1005             


Glu Lys  Leu Arg Thr Glu Ile  Leu Arg Ser Ile His  Asp Gly Pro 
    1010                 1015                 1020             


Lys Pro  Lys Asp Lys Asp Phe  Trp Pro Lys Leu Glu  Ala Lys Cys 
    1025                 1030                 1035             


Leu Glu  Tyr Arg Thr Val Ala  Thr Glu Thr Ala Ile  Tyr Asn Phe 
    1040                 1045                 1050             


Gln Ala  Asn Ala Ala Arg Leu  Asn Asp His Ala Arg  Leu His Gln 
    1055                 1060                 1065             


Ile Val  Met Arg Val Val Ala  Arg Leu Thr Asp Tyr  Ala Leu Ile 
    1070                 1075                 1080             


Trp Glu  Arg Asp Arg Leu Phe  Ala Phe Val Gly Met  Leu Tyr Arg 
    1085                 1090                 1095             


Gln Thr  Gly Gly Thr Gly Ile  Asn Pro Ala Met Arg  His Ala Glu 
    1100                 1105                 1110             


Lys Thr  Asn Ala Pro Pro Arg  Ile Gly Ile Leu Val  Ser Asp Ser 
    1115                 1120                 1125             


Ala Leu  Ala Lys Lys Leu Asn  Ser Asn Ser Ala Glu  Val Phe Ile 
    1130                 1135                 1140             


Pro Tyr  Leu Asp Thr Glu Thr  Gly Phe Asp Ala Pro  Arg Phe Asp 
    1145                 1150                 1155             


Asp Leu  Cys Thr Leu Leu Ser  His Glu His Ala Lys  Glu Phe Arg 
    1160                 1165                 1170             


Phe His  Phe Leu Glu Val Gly  Glu Glu Asn Ser Lys  Asp Glu Ala 
    1175                 1180                 1185             


Arg Arg  Leu Asn Glu Glu Thr  Met Gly His Arg Lys  Arg Pro Ala 
    1190                 1195                 1200             


Phe Lys  Arg Gly Thr Arg Arg  Gln Gly Ile Arg Asn  Asp Leu Ala 
    1205                 1210                 1215             


His His  Asn Val Leu Asp Leu  Ala Gly Gly Ala Gly  Pro Asn Leu 
    1220                 1225                 1230             


Thr Tyr  Met Val Asn Ala Val  Arg Ser Leu Leu Ser  Tyr Asp Arg 
    1235                 1240                 1245             


Lys Leu  Lys Asn Ala Val Pro  Lys Ser Ile Lys Arg  Ile Leu Gly 
    1250                 1255                 1260             


Glu Glu  Gly Leu Ile Ile Glu  Trp Gln Met Asn Tyr  Asp Arg Leu 
    1265                 1270                 1275             


Lys Lys  Pro Thr Val Tyr Pro  Asn Val Glu Thr His  Leu Thr Met 
    1280                 1285                 1290             


Val Pro  Pro Arg His Met Thr  Ala Pro Val Ser Phe  Thr Leu Pro 
    1295                 1300                 1305             


Arg Ala  Ser Val Arg Leu Ala  Ser Met Val Lys Ala  Val Phe Asp 
    1310                 1315                 1320             


Phe Gly  Ser Ser Gly Tyr Gly  Glu Glu Arg Met Ile  Gly Gly Arg 
    1325                 1330                 1335             


Thr Ala  Lys Gln Ala Val Tyr  Pro Asp Asp Phe Thr  Arg Arg Phe 
    1340                 1345                 1350             


Pro Gln  Thr Pro Met Gly Leu  Lys Gln Ala Thr Arg  Leu Val Phe 
    1355                 1360                 1365             


Ala Ser  Glu Asn Ser 
    1370             


<210>  999
<211>  1426
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  999

Met Gly Glu Phe Ser Leu Lys Gln Lys Asn Thr Arg Val Arg Ile Asp 
1               5                   10                  15      


Arg Val Gly Arg Lys Arg His Met Asp Phe Gly Thr Ser Arg Thr Cys 
            20                  25                  30          


Cys Ile Phe Gly Asp Ala Arg Arg Val Lys Lys Tyr Thr Arg Ala Glu 
        35                  40                  45              


Glu Ser Arg Met Lys Ile Ser Lys Glu Asn His Lys Arg Thr Ala Val 
    50                  55                  60                  


Ala Val Lys Glu Asn Arg Val Gly Gly Val Val Tyr Lys Val Pro Gly 
65                  70                  75                  80  


Ser Ser Glu Ile Asp Leu Asn Lys Tyr Leu Ala Lys Arg Ser Val Asp 
                85                  90                  95      


Thr Lys Ile Leu Tyr Asn Ile Phe Asn Gln Ile Gln Ala Gly Thr Ala 
            100                 105                 110         


Pro Ser Glu Tyr Glu Trp Lys Asp Tyr Leu Ser Glu Thr Glu Asn Lys 
        115                 120                 125             


Lys Arg Glu Ala Gln Lys Thr Ile Gln Lys Lys Asn Tyr Glu Leu Arg 
    130                 135                 140                 


Ser Ala Cys Gly Asp Tyr Ala Lys Lys Ala Asn Phe Val Ile Gly Lys 
145                 150                 155                 160 


Ile Ile Phe Ser Glu Lys Pro Lys Arg Ile Leu Ser Asp Glu Gln Ile 
                165                 170                 175     


Ile Phe Asn Met Lys Val Gln Arg Leu Ser Lys Phe Lys Gly Arg Leu 
            180                 185                 190         


Glu Asp Phe Val Leu Leu Thr Leu Arg Lys Ser Leu Ile Val Ser Thr 
        195                 200                 205             


Tyr Asn Glu Glu Val Phe Asp Ser Arg Asn Ala Thr Thr Val Phe Leu 
    210                 215                 220                 


Lys Asn Ile Gly Lys Glu Asn Ile Ser Ala Asp Asp Glu Arg Gln Ile 
225                 230                 235                 240 


Lys Gln Leu Leu Ala Leu Ile Arg Glu Asp Tyr Asn Lys Trp Asn Leu 
                245                 250                 255     


Asp Glu Gln Ser Ser Asp Lys Met Tyr Ser Asp Lys Lys Glu Ser Lys 
            260                 265                 270         


Gly Thr Ile Val Ile Arg Ser Ile Glu Tyr Gln Asn Met Val Ile Gln 
        275                 280                 285             


Pro Lys Glu Asp Arg Leu Cys Leu Ser Glu Ile Ser Asn Val Gly Lys 
    290                 295                 300                 


Asn Thr Lys Thr Lys Gln Thr Glu Lys Ala Gly Leu Glu Ala Phe Leu 
305                 310                 315                 320 


Thr Glu Tyr Ala Gln Ile Asp Ala Asn Ser Arg Met Glu Tyr Leu Lys 
                325                 330                 335     


Lys Leu Arg Arg Leu Leu Asp Thr Tyr Phe Ala Ala Pro Phe Ser Tyr 
            340                 345                 350         


Ile Lys Gly Ala Glu Val Ser Leu Pro Glu Asn Ile Asn Phe Ser Ser 
        355                 360                 365             


Glu Leu Lys Val Trp Glu Arg His Ala Ala Ala Lys Lys Val Asn Ile 
    370                 375                 380                 


Tyr Phe Val Glu Ile Pro Glu Ala Leu Leu Lys Ala Glu Gln Asn Asn 
385                 390                 395                 400 


Asn Met Ile Asp Lys Val Glu Lys Glu His Ser Leu Glu Gln Leu Arg 
                405                 410                 415     


Thr Asp Ile Arg Cys Arg Asn Ile Val Cys Tyr His Phe Ala Asn Ala 
            420                 425                 430         


Val Ala Ala Asp Glu Arg Tyr His Thr Leu Phe Phe Glu Asn Met Ser 
        435                 440                 445             


Met Asn Gln Tyr Trp Ile His His Met Glu Asn Ala Val Glu Arg Ile 
    450                 455                 460                 


Leu Lys Lys Cys Asn Val Gly Thr Leu Phe Lys Leu Gln Ile Gly Tyr 
465                 470                 475                 480 


Leu Ser Glu Lys Val Trp Lys Asp Leu Leu Asn Leu Leu Ser Ile Lys 
                485                 490                 495     


Tyr Ile Ala Leu Gly Lys Ala Val Tyr His Phe Ala Leu Asp Asp Ile 
            500                 505                 510         


Trp Asn Asp Val Ser Asp Lys Lys Leu Gly Lys Ile Asn Ala Asn Thr 
        515                 520                 525             


Leu Lys Gly Ile Ser Ser Phe Asp Tyr Glu Met Leu Lys Ala Gln Glu 
    530                 535                 540                 


Asp Leu Gln Arg Glu Met Ala Val Gly Val Ala Phe Ser Thr Asn Asn 
545                 550                 555                 560 


Leu Ser Arg Ala Thr Cys Gln Met Asn Asn Leu Ala Asp Arg Glu Ser 
                565                 570                 575     


Asp Phe Leu Leu Trp Asp Glu Lys Val Ile Ala Lys His Ile Lys Ser 
            580                 585                 590         


Thr Glu Lys Gly Glu Ile Leu Ser Ala Ile Leu Gln Phe Phe Gly Gly 
        595                 600                 605             


Arg Ser Ser Trp Asp Glu Ser Leu Phe Glu Asn Ala Tyr Ser Asp Phe 
    610                 615                 620                 


Asn Tyr Glu Leu Gln Phe Leu Asn Asp Leu Lys Arg Ala Ile Tyr Ala 
625                 630                 635                 640 


Ala Arg Asn Glu Thr Phe His Phe Lys Thr Ala Ala Ile Asp Glu Gly 
                645                 650                 655     


Ser Trp Asn Thr Arg Leu Phe Gly Asn Met Phe Glu Lys Glu Ala Gly 
            660                 665                 670         


Ile Cys Leu Asp Val Glu Lys Asn Lys Phe Tyr Ser Asn Asn Leu Ala 
        675                 680                 685             


Leu Phe Tyr Thr Gln Lys Asp Leu Arg Val Ile Leu Asp Glu Leu Tyr 
    690                 695                 700                 


Gly Lys Glu Cys Phe Arg Ala Ala Gln Ile Pro Ser Tyr Asn Thr Ile 
705                 710                 715                 720 


Leu Pro Arg Lys Ser Phe Pro Asp Phe Leu Lys Gln Leu Leu Lys Leu 
                725                 730                 735     


His Glu Pro Ala Tyr Asp Leu Ala Ile Arg Asp Gln Trp Tyr Ser Ala 
            740                 745                 750         


Cys Tyr Tyr Leu Phe Lys Glu Val Tyr Tyr Asn Leu Phe Leu Gln Ser 
        755                 760                 765             


Ser Ser Ala Lys Glu Leu Phe Glu Asp Ala Val Lys Glu Leu Arg Gly 
    770                 775                 780                 


Ala Asp Glu Lys Gln Lys Arg Ala Val Glu Asn Phe Lys Lys Arg Tyr 
785                 790                 795                 800 


Arg Glu Ile Ser Ile Ser Ala Ser Leu Ala Asp Ile Cys Gln Ser Phe 
                805                 810                 815     


Met Thr Glu Tyr Asn Gln Gln Asn Asn Lys Asp Arg Lys Val Arg Ser 
            820                 825                 830         


Ala Asn Asp Gly Met Phe Asn Glu Pro Ile Tyr Gln His Tyr Arg Met 
        835                 840                 845             


Leu Leu Arg Glu Ala Leu Lys Val Ala Phe Ala Ser Tyr Ile Lys Asn 
    850                 855                 860                 


Asn Lys Glu Leu Glu Phe Val Phe Asn Pro Thr Lys Asn Leu Phe Asn 
865                 870                 875                 880 


Val Thr Ser Asp Ser Phe Leu Pro Asn Trp Ser Ser Gly Lys Tyr Asp 
                885                 890                 895     


Ser Leu Ile Ser Glu Val Lys Asn Ser Pro Glu Leu Gln Lys Trp Tyr 
            900                 905                 910         


Ile Val Gly Lys Phe Met Asn Ala Arg Met Leu Asn Leu Thr Ile Gly 
        915                 920                 925             


Ser Met Arg Ser Tyr Cys Gln Tyr Val Asn Asp Ile Gln Lys Arg Ala 
    930                 935                 940                 


Ala Ser Leu Gly Gly Arg Gln Leu His Leu Phe Val Gly Asn Val Glu 
945                 950                 955                 960 


Gln Val Lys Lys Trp Ile Gln Val Leu Glu Cys Cys Leu Leu Leu Ser 
                965                 970                 975     


Val Arg Ile Ser Asn Glu Phe Lys Asp Tyr Phe Lys Asp Glu Asp Ala 
            980                 985                 990         


Tyr Ala Ser Tyr Leu Lys Gly Tyr  Val Asp Phe Lys Asp  Ser Ile Met 
        995                 1000                 1005             


Pro Ser  Asp Tyr Ser Ala Leu  Leu Ala Phe Ser Asp  Glu Gly Lys 
    1010                 1015                 1020             


Ile Asp  Leu Tyr Val Asp Ala  Ser Asn Pro Lys Val  Asn Arg Asn 
    1025                 1030                 1035             


Ile Ile  Gln Ser Lys Leu Tyr  Ala Pro Asp Leu Val  Leu Lys Lys 
    1040                 1045                 1050             


Val Val  Lys Lys Ile Ser Lys  Asp Glu Cys Arg Glu  Phe Asn Val 
    1055                 1060                 1065             


Lys Lys  Glu Gln Ile Leu Gln  Ile Lys Asn Lys Gly  Asp Glu Val 
    1070                 1075                 1080             


Ser Trp  Glu Glu Gln Gln Arg  Ile Leu Glu Tyr Gln  Lys Leu Lys 
    1085                 1090                 1095             


Asn Arg  Val Glu Leu Arg Asp  Leu Ser Glu Tyr Gly  Glu Leu Ile 
    1100                 1105                 1110             


Asn Glu  Leu Leu Gly Gln Leu  Ile Asn Trp Ser Tyr  Leu Arg Glu 
    1115                 1120                 1125             


Arg Asp  Leu Leu Tyr Phe Gln  Leu Gly Phe His Tyr  Ser Cys Leu 
    1130                 1135                 1140             


Met Asn  Lys Ser Lys Lys Pro  Asp Ala Tyr Lys Thr  Ile Cys Ile 
    1145                 1150                 1155             


Asp Asp  Thr Ala Ser Ile Glu  Asn Ala Val Leu Tyr  Gln Ile Ile 
    1160                 1165                 1170             


Ala Met  Tyr Ile Asn Gly Phe  Pro Val Tyr Val Pro  Glu Lys Gly 
    1175                 1180                 1185             


Lys Leu  Lys Ala Gln Cys Lys  Ala Gly Ser Val Gly  Gln Lys Val 
    1190                 1195                 1200             


Gly Ala  Phe Cys Arg Trp Ala  Ser Arg Val Glu Glu  Asn Glu Tyr 
    1205                 1210                 1215             


Glu Leu  Tyr Asn Ala Gly Leu  Glu Leu Phe Glu Val  Val Lys Glu 
    1220                 1225                 1230             


His Ser  Asn Val Ile Asp Leu  Arg Asn Lys Phe Asp  His Phe Lys 
    1235                 1240                 1245             


Tyr Tyr  Gln Gly Asn Asp Ser  Ile Leu Ser Leu Tyr  Gly Glu Ile 
    1250                 1255                 1260             


Phe Asp  Arg Phe Phe Thr Tyr  Asp Met Lys Tyr Arg  Lys Asn Val 
    1265                 1270                 1275             


Leu Asn  His Leu Gln Asn Ile  Leu Leu Arg His Asn  Val Val Ile 
    1280                 1285                 1290             


Lys Pro  Val Ile Ser Lys Asp  Lys Lys Glu Val Gly  Lys Gly Glu 
    1295                 1300                 1305             


Thr Lys  Asp Gly Ala Ser Phe  Leu Leu Glu Glu Val  Ser Ser Asp 
    1310                 1315                 1320             


Arg Phe  Thr Tyr Lys Val Lys  Asp Gly Glu Arg Lys  Leu Asp Val 
    1325                 1330                 1335             


Lys Asn  Arg Leu Tyr Leu Glu  Thr Val Arg Asp Ile  Leu Tyr Phe 
    1340                 1345                 1350             


Pro Asn  Lys Ala Val Asn Asp  Lys Gly Glu Asp Val  Val Val Arg 
    1355                 1360                 1365             


Ser Gln  Lys Ala Gln Asp Ser  Asn Glu Lys Lys Val  Asp Arg Asp 
    1370                 1375                 1380             


Lys Asn  His Asp Lys Ile Lys  Asn Gly Asn Trp Lys  Lys Gly Gly 
    1385                 1390                 1395             


Asn Asn  Gln Arg Arg Lys Pro  Lys Ser Glu Glu Ala  Tyr Ser Asp 
    1400                 1405                 1410             


Arg Ile  Thr Trp Asn Pro Phe  Ala Gly Ile Lys Leu  Asp 
    1415                 1420                 1425     


<210>  1000
<211>  1184
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1000

Met Arg Val Ser Lys Val Lys Val Leu Gly Asn Glu Glu Thr Lys Gly 
1               5                   10                  15      


Arg Ile Val Leu Met His Arg Ser Pro Val Lys Gly Gln Leu Ile Tyr 
            20                  25                  30          


Ser Glu Asp Ala Gly Lys Arg Asp Arg Thr Glu Asp Ile Ile Pro Glu 
        35                  40                  45              


Gln Lys Leu Glu Ser Phe His Leu Ser Ile Leu Asn Lys Thr Phe Leu 
    50                  55                  60                  


Arg Lys Glu Phe Phe Lys Lys Glu Leu Lys His Glu Ala Lys Lys Asn 
65                  70                  75                  80  


Gly Leu Lys Gly Asp Ala Glu Asp Lys Tyr Ile Ser Glu Lys Leu Lys 
                85                  90                  95      


Glu Tyr His Ser Leu Leu Gln Phe Ile Asp Asp Val Leu Ser Val Lys 
            100                 105                 110         


Tyr Asn Glu Asn Arg Lys Ala Ile Lys Phe Pro Glu Tyr Leu Thr Arg 
        115                 120                 125             


Glu Met Ile Glu Ile Phe Leu Asn His Lys Phe Arg Lys Glu Val Thr 
    130                 135                 140                 


Tyr Thr Asn Lys Asn Gly Ala Ser Val Ser Phe Leu Leu Ser Thr Leu 
145                 150                 155                 160 


Ile Leu Asn Ala Ile Glu Lys His Ser Val Ile Glu Met Gln Pro Phe 
                165                 170                 175     


Val Asp Trp Arg Asn Trp Phe Val Glu Thr Lys Ser Lys Phe Leu Lys 
            180                 185                 190         


Lys Ser Ile Ile Asn Asn Cys Ile Pro Thr Asn Gly Gly Pro Ile Ser 
        195                 200                 205             


Arg Arg Arg Glu Thr Leu Met Lys Trp Arg Asp Asp Tyr Phe Thr Asn 
    210                 215                 220                 


Ala Glu Ile Asp Leu Ala Arg Leu His Lys Lys Phe Gly Thr Asp Thr 
225                 230                 235                 240 


Leu Met Ala Ser Leu Arg Glu Val Pro Gln Thr Glu Lys Ser Gly Asn 
                245                 250                 255     


Glu Tyr His Arg Leu Leu Lys Ser Cys Leu Gln Ser His Gln Lys Lys 
            260                 265                 270         


Leu Phe Gly Lys Arg Ala Glu Gly Tyr Asp Ile Asn Arg Ala Asp Asn 
        275                 280                 285             


Gln Leu Tyr Val Tyr Asn Thr Glu Val Val Lys Tyr Met Glu His Tyr 
    290                 295                 300                 


Phe Pro Val Lys Ser Ser Lys Arg Arg Asn Ser Thr Ala Glu Ile Lys 
305                 310                 315                 320 


Tyr Tyr Leu Gln Thr Asp Thr Ile Lys Cys Cys Leu His His Gln Ile 
                325                 330                 335     


Ile Asn Ala Val Arg Gly Leu Ala Leu Arg Glu Gly Lys Phe Asn Leu 
            340                 345                 350         


His Gly Phe Asp Asp Lys Leu Ile Pro Asn Glu Arg Asn Val Ser Ser 
        355                 360                 365             


Ser Ile Leu Asn Glu Leu Lys Thr Ser Glu Gly Phe Val Leu Asn Met 
    370                 375                 380                 


Leu Gly Gly Cys Ala Phe Ala Ala Asn Cys Leu Arg Asn Ile Val Asp 
385                 390                 395                 400 


Ala Thr Gln Arg Ser Asp Leu Leu Gly Phe Arg Cys Phe Glu Val Ser 
                405                 410                 415     


Leu Lys Lys Gly Lys Ser Asn Ser Asp Leu Phe Ala Leu Phe Phe Gly 
            420                 425                 430         


Phe Gly Arg Glu Asp Met Asp Asp Asp Ser Glu Trp Glu Lys His Leu 
        435                 440                 445             


Tyr Ala Ala Arg Tyr Ser Val Ser Glu Ile Arg Asn Arg Val Ala His 
    450                 455                 460                 


Tyr His Lys Ser Ala Ile Glu Asn Ile Tyr Asn Ile Thr Asp Phe Glu 
465                 470                 475                 480 


Tyr Arg Glu Asn Ser Met Cys Ser Tyr Thr Asp Thr Lys Phe Thr Thr 
                485                 490                 495     


Ala Leu Gln Asn Glu Ile Tyr Asn Thr Pro Lys Ala Phe Ser Leu Gln 
            500                 505                 510         


Leu Met Thr Gly Lys Val Leu Glu Tyr Tyr Pro Lys Glu Lys Leu Val 
        515                 520                 525             


Ser Phe Phe Gln Lys Tyr Lys Phe Ser Leu Tyr Arg Ser Val Val Pro 
    530                 535                 540                 


Phe Ala Pro Gly Phe Lys Asn Ile Met Arg Thr Gly Val Asn Tyr Gln 
545                 550                 555                 560 


Asn Ala Thr Gln Asn Arg Leu Phe Tyr Asp Met Gly Leu Thr Ala Phe 
                565                 570                 575     


Gln Asp Lys Asp Arg Tyr Ile Asp Asp Val Glu Ala Trp Asn Ala Arg 
            580                 585                 590         


Tyr Phe Phe Met Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Arg Phe 
        595                 600                 605             


Thr Asn Asp Lys Asn Asp Leu Phe Arg Lys Thr Val Glu Gln Val Leu 
    610                 615                 620                 


Glu Val Asn Arg Ser His Met Glu Lys Val Gly Lys Asp Asp Arg Gln 
625                 630                 635                 640 


Ala Phe Gly Glu Val Arg Gln Met Arg Glu Asn Glu Thr Ala Asn Asp 
                645                 650                 655     


Tyr Met Ala Tyr Leu Gln Ser Ser Leu Arg Met Glu Lys Asn Lys Lys 
            660                 665                 670         


Glu Leu Glu Gly Asn Gly Ala Lys Arg Ile Asn Phe Glu Lys Phe Ile 
        675                 680                 685             


Leu Gln Met Phe Val Lys Gly Phe Asp Ser Phe Leu Lys Asp Gly Ala 
    690                 695                 700                 


Phe Glu Phe Val His Ser Pro Glu Asn Cys Leu Thr Gly Ser Thr Glu 
705                 710                 715                 720 


Lys Glu Arg Ala Lys Glu Arg Asn Ser Leu Cys Glu Glu Ile Gly Asn 
                725                 730                 735     


Tyr Val Arg Leu Val Ser Thr Val Ile Asp Pro Gly Lys Gly Ser His 
            740                 745                 750         


Val Ala Phe Tyr Val Phe Cys Lys Met Leu Asn Ser Val Tyr Leu Ser 
        755                 760                 765             


Asn Ile Arg Asn Glu Met Ile Lys Tyr His Lys Val Val Arg Thr Asp 
    770                 775                 780                 


Glu Leu Ala His Leu Ile Glu Ile Ile Glu Leu Cys Leu Leu Ser Ala 
785                 790                 795                 800 


Asp Ala Val Ser Gln Lys Thr Val Asn Ala Asp Lys Leu Ser His Phe 
                805                 810                 815     


Phe Ala Glu Gly Val Asn Val Asp Asp Asp Glu Asn Val Ile His Ala 
            820                 825                 830         


Ser Met Glu Thr Phe Arg Lys Tyr Gly Thr Arg Asp Leu Phe His Lys 
        835                 840                 845             


Leu Met Leu Gln Asp Asp Arg Phe Leu Val Ser Ser Asp Asp Tyr Arg 
    850                 855                 860                 


Glu Trp Glu Glu Met Lys Glu Lys Ile Glu Gly Lys Val Lys Gln Arg 
865                 870                 875                 880 


Glu Leu Leu His Ala Glu Trp Cys Glu Ala Lys Glu Lys Asp Lys Lys 
                885                 890                 895     


Ser Arg Lys Val Lys Ser Asn Ser Arg Thr Cys Phe Glu Lys Lys Phe 
            900                 905                 910         


Met Gly Ala Lys Ala Glu Glu Tyr Tyr Ser Leu Cys Asn Val Ile Asp 
        915                 920                 925             


Lys Tyr Asn Trp Leu Asp Asn Lys Leu His Leu Val His Leu Asn Lys 
    930                 935                 940                 


Leu His Asn Leu Val Ile Glu Ile Leu Gly Arg Met Val Gly Phe Thr 
945                 950                 955                 960 


Ala Leu Phe Glu Arg Asp Phe Gln Tyr Ile Cys Lys Ser Asp Ser Glu 
                965                 970                 975     


Tyr Glu Gln Leu Tyr Asn Leu Asp Phe Asn Met Gly Leu Pro Lys Phe 
            980                 985                 990         


Lys Asn Ser Ile Lys Gly Ser Gly  Lys Ala Lys Asn Ser  Thr Gln Asn 
        995                 1000                 1005             


Ile Asp  His Asn Ala Thr Gly  Ile Gly Asn Ser Ser  Asn Leu Leu 
    1010                 1015                 1020             


Lys Glu  Asn Ser Asn Gly Thr  His Tyr Cys Lys Asn  Leu Ser Gly 
    1025                 1030                 1035             


Asp Gly  Val Glu Asp Lys Leu  Lys Arg Leu Phe Leu  Tyr Asp Asp 
    1040                 1045                 1050             


Tyr Arg  Asn Val Arg Asn Phe  Val Ala His Phe Asn  Tyr Leu Thr 
    1055                 1060                 1065             


Arg Val  Glu Asp Asp Leu Gly  Gly Asn Asp Ala Val  Lys Leu Ser 
    1070                 1075                 1080             


Gly Thr  Arg Tyr Ser Leu Ile  Glu Leu Ile Asn Glu  Leu Arg Asn 
    1085                 1090                 1095             


Leu Leu  Lys Tyr Asp Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ser 
    1100                 1105                 1110             


Phe Ile  Asp Met Phe Glu Arg  His Gly Met His Val  Lys Met Lys 
    1115                 1120                 1125             


Leu Asn  His Asn His Lys Leu  Phe Val Asp Ser Ile  Ser Pro Arg 
    1130                 1135                 1140             


Lys Ile  Lys His Leu Gly Gly  Gly Tyr Lys Lys Arg  Gly Lys Asp 
    1145                 1150                 1155             


Asp Lys  Met Tyr Val Gln Thr  Thr Asn His Val Asp  Pro Leu Tyr 
    1160                 1165                 1170             


Cys Asp  Met Cys Arg Ala Leu  Leu Glu Met Lys 
    1175                 1180                 


<210>  1001
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1001

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Thr Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Tyr Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asn Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Val Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Val 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Lys Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Met 
    690                 695                 700                 


Tyr Ile Gly Asn Asp Glu Gln Ile Asn Thr Ser Leu Ala Gly Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Lys Ile Leu Lys Tyr Thr Glu Ser Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Lys Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Leu Lys Glu Leu Lys Glu Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn Tyr Thr Met Gln Gln Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Lys Lys Asp Glu Lys Phe Asn Asp Glu Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Ile Met Lys Ser  Val Val Asn Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Lys Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Lys Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Glu  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  1002
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1002

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  1003
<211>  1197
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1003

Met Lys Ile Thr Lys Ile Asp Gly Val Ser His Tyr Lys Lys Gln Asp 
1               5                   10                  15      


Lys Gly Ile Leu Lys Lys Lys Trp Arg Asp Leu Gly Glu Gly Lys Gln 
            20                  25                  30          


Arg Glu Lys Ile Glu Ala Arg Tyr Asn Lys Gln Ile Glu Ser Lys Ile 
        35                  40                  45              


Tyr Lys Glu Phe Phe Arg Leu Lys Ser Gly Lys Asp Ser Glu Arg Ile 
    50                  55                  60                  


Thr Lys Glu Lys Asn Glu Gly Ile Lys Ser Leu Tyr Tyr Leu Ile Lys 
65                  70                  75                  80  


Glu Leu Tyr Glu Gly Lys Glu Asn Asp Leu Trp Glu Leu Lys Asn Ile 
                85                  90                  95      


Asn Leu Glu Ile Leu Gly Asp Lys Glu Arg Ile Ile Lys Gly Tyr Lys 
            100                 105                 110         


Phe Lys Glu Asp Val Tyr Phe Phe Lys Glu Gly Asp Lys Glu Tyr Tyr 
        115                 120                 125             


Leu Arg Thr Leu Leu Asn Asn Leu Ile Glu Lys Ile Gln Asn Glu Asn 
    130                 135                 140                 


Arg Glu Lys Val Arg Lys Asn Lys Glu Phe Leu Asp Leu Lys Glu Ile 
145                 150                 155                 160 


Phe Lys Lys Tyr Lys Asp Arg Lys Ile Asp Leu Leu Leu Lys Ser Ile 
                165                 170                 175     


Asn Asn Asn Lys Ile Asn Leu Glu Tyr Lys Lys Glu Asn Val Asn Glu 
            180                 185                 190         


Glu Ile Tyr Gly Ile Asn Pro Thr Asn Asp Arg Glu Met Thr Phe Tyr 
        195                 200                 205             


Glu Leu Leu Lys Glu Ile Ile Glu Lys Lys Asp Glu Gln Lys Ser Ile 
    210                 215                 220                 


Leu Glu Glu Lys Leu Asp Asn Phe Asp Ile Thr Asn Phe Leu Glu Asn 
225                 230                 235                 240 


Ile Glu Lys Ile Phe Asn Glu Glu Thr Glu Ile Asn Ile Ile Lys Gly 
                245                 250                 255     


Lys Val Leu Asn Glu Leu Arg Glu Tyr Ile Lys Glu Lys Glu Glu Asn 
            260                 265                 270         


Asn Ser Asp Asn Lys Leu Lys Gln Ile Tyr Asn Leu Glu Leu Lys Lys 
        275                 280                 285             


Tyr Ile Glu Asn Asn Phe Ser Tyr Lys Lys Gln Lys Ser Lys Ser Lys 
    290                 295                 300                 


Asn Gly Lys Asn Asp Asp Leu Tyr Leu Asn Phe Leu Lys Lys Ile Met 
305                 310                 315                 320 


Phe Ile Glu Glu Ala Asp Glu Lys Lys Glu Ile Asn Lys Glu Lys Ile 
                325                 330                 335     


Lys Asn Lys Ile Asn Ser Asn Phe Lys Asn Leu Phe Val Gln His Ile 
            340                 345                 350         


Leu Asp Tyr Gly Lys Leu Leu Tyr Tyr Lys Glu Asn Asp Glu Tyr Ile 
        355                 360                 365             


Lys Asn Thr Gly Gln Leu Glu Thr Lys Asp Leu Glu Tyr Ile Lys Thr 
    370                 375                 380                 


Lys Glu Thr Leu Ile Arg Lys Met Ala Val Leu Val Ser Phe Ala Ala 
385                 390                 395                 400 


Asn Ser Tyr Tyr Asn Leu Phe Gly Arg Thr Glu Asn Asn Ile Leu Thr 
                405                 410                 415     


Gln Glu Ile Ser Asp Asp Leu Leu Leu Gly Lys Ile Glu Asn Glu Ile 
            420                 425                 430         


Tyr Ile Lys Gly Glu Arg Asn Arg Arg Tyr Val Phe Lys Glu Lys Met 
        435                 440                 445             


Leu Asn Tyr Phe Phe Asn Ser Glu Ile Phe Gly Asp Asn Lys Ile Val 
    450                 455                 460                 


Glu Val Leu Asn Ala Ile Ser Ser Ser Ile Tyr Asn Ile Arg Asn Gly 
465                 470                 475                 480 


Val Asn His Phe Asp Lys Met Ile Leu Gly Lys Cys Ser Asn Gly Ser 
                485                 490                 495     


Asp Leu Lys Asp Ser Asp Thr Ile Lys Asp Tyr Phe Asn Phe Lys Lys 
            500                 505                 510         


Lys Glu Ile Gln Gln Asp Leu Lys Asp Arg Phe Ile Ser Asn Asn Leu 
        515                 520                 525             


Gln Tyr Tyr Tyr Thr Glu Asn Glu Ile Lys Lys Tyr Phe Glu Lys Tyr 
    530                 535                 540                 


Lys Phe Glu Ile Leu Lys Thr Lys Ala Ser Phe Ala Pro Asn Phe Lys 
545                 550                 555                 560 


Arg Ile Leu Thr Lys Gly Glu Asn Leu Ser Ile Ser Lys Ser Ser Asn 
                565                 570                 575     


Asp Tyr Glu Phe Phe Lys Ala Tyr Ser Glu Ser Ser Asp Lys Asn Ser 
            580                 585                 590         


Glu Tyr Asn Glu Phe Met Lys Thr Arg Asn Phe Leu Leu Lys Glu Leu 
        595                 600                 605             


Tyr Tyr Asn Asn Phe Tyr Thr Glu Phe Leu Asn Asp Lys Ala Lys Phe 
    610                 615                 620                 


Arg Glu Ala Val Glu Lys Val Lys Lys Asn Lys Lys Arg Arg Gly Gly 
625                 630                 635                 640 


Lys Ser Tyr Asp Val Ile Gly Asn Tyr Asn Phe Ser Asp Ser Ile Ser 
                645                 650                 655     


Glu Tyr Ile Ser Tyr Ile His Lys Ser Glu Met Glu Arg Ile Glu Ile 
            660                 665                 670         


Asn Thr Glu Lys Asn Arg Lys Asp Thr Ser Lys His Ile Arg Asp Phe 
        675                 680                 685             


Ile Glu Glu Ile Phe Leu Glu Gly Phe Ile Glu Tyr Leu Asp Asn Asn 
    690                 695                 700                 


Asn Phe Lys Phe Leu Lys Asn Arg Asn Glu Val Asp Lys Glu Arg Glu 
705                 710                 715                 720 


Glu Ile Val Arg Asn Leu Asn Ile Arg Ile Glu Gly Leu Asp Ile Leu 
                725                 730                 735     


Asn Glu Asp Asp Ser Glu Ile Leu Asn Leu Tyr Leu Phe Phe Asn Met 
            740                 745                 750         


Ile Asp Asn Lys Arg Ile Ser Glu Phe Arg Asn Asp Met Ile Lys Tyr 
        755                 760                 765             


Lys Gln Phe Leu Ala Lys Arg Gln Asn Ile Asp Ser Lys Phe Leu Lys 
    770                 775                 780                 


Ile Asp Ile Glu Lys Ile Glu Ala Ile Ile Glu Phe Val Ile Ile Thr 
785                 790                 795                 800 


Lys Glu Lys Leu Glu Ile Leu Glu Asp Glu Thr Lys Glu Gln Lys Lys 
                805                 810                 815     


Asp Asn Met Asn Ala Leu Phe Asn Lys Phe Tyr Ser Ser Glu Ser Glu 
            820                 825                 830         


Tyr Asp Glu Lys Leu Lys Lys Phe Ile Glu Glu Ala Ile Leu Gly Asp 
        835                 840                 845             


Lys Lys Asn Thr Pro Phe Tyr Ser Thr Asp Gly Lys Thr Pro Ile Val 
    850                 855                 860                 


His Ser Asn Leu Glu Lys Met Lys Lys Tyr Gly Thr Glu Asn Phe Leu 
865                 870                 875                 880 


Ser Lys Val Leu Lys Asp Ser Asn Tyr Thr Leu Asn Asn Met Thr Ala 
                885                 890                 895     


Lys Glu Lys Phe Glu Ala Lys Val Ser Asp Glu Leu Lys Glu His Lys 
            900                 905                 910         


Ile Leu Glu Lys Val Asn Lys Phe Asn Lys Lys Gly Lys Ser Lys Lys 
        915                 920                 925             


Val Ile Glu Tyr Tyr Asn Asp Cys Arg Cys Tyr Leu His Lys Lys Trp 
    930                 935                 940                 


Ile Glu Lys Lys Lys Ser Glu Glu Glu Phe Glu His Lys Glu Ile Tyr 
945                 950                 955                 960 


Lys Lys Ile Ile Glu Glu Ile Arg Lys Tyr Asn Tyr Leu Glu Asn Lys 
                965                 970                 975     


Glu Lys Leu Gln Asn Val Tyr Leu Leu His Glu Ile Leu Ser Asp Leu 
            980                 985                 990         


Leu Ala Arg Asn Val Ala Phe Leu  Asn Lys Trp Glu Arg  Asp Phe Lys 
        995                 1000                 1005             


Phe Ile  Val Ile Ala Ile Lys  Gln Phe Leu Arg Glu  Asn Asp Lys 
    1010                 1015                 1020             


Glu Lys  Val Asp Glu Phe Leu  Asn Pro His Lys Ser  Asp Gly Ser 
    1025                 1030                 1035             


Arg Asp  Asn Phe Ser Val Thr  Asn Tyr Arg Ser Lys  Met Lys Ser 
    1040                 1045                 1050             


Ile Ile  Asn Asn Ile His Glu  Asn Phe Met Ser Leu  Leu Phe Leu 
    1055                 1060                 1065             


Asn Asn  Asn Leu Ala Thr Gly  Gly Met Gln Met Gly  Arg Asn Asn 
    1070                 1075                 1080             


Asn Phe  Thr Trp Gly Asn Leu  Arg Asn Tyr Ile Ala  His Phe Glu 
    1085                 1090                 1095             


Tyr Leu  His Lys Glu Lys Asp  Thr Ile Ser Phe Ile  Gly Gln Ala 
    1100                 1105                 1110             


Asn Leu  Leu Ile Lys Leu Phe  Ser Tyr Asp Lys Lys  Val Gln Asn 
    1115                 1120                 1125             


His Ile  Ile Lys Ser Met Lys  Thr Leu Leu Glu Lys  Tyr Asn Ile 
    1130                 1135                 1140             


Glu Ile  Arg Phe Glu Ile Ser  Asn Asp Arg Glu Glu  Ile Phe Glu 
    1145                 1150                 1155             


Tyr Lys  Ile Lys Tyr Ile Asn  Ser Lys Lys Gly Lys  Met Leu Gly 
    1160                 1165                 1170             


Lys Asn  Asn Glu Phe Glu Ile  Leu Glu Asn Glu Phe  Val Arg Asn 
    1175                 1180                 1185             


Val Lys  Ala Leu Leu Glu Tyr  Ser Glu 
    1190                 1195         


<210>  1004
<211>  1102
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1004

Met Arg Val Ser Lys Val Lys Val Asp Asn Lys Asn Met Val Leu Met 
1               5                   10                  15      


Arg Arg Thr Thr Gly Asn Gly Ala Leu Val Tyr Glu Gly Glu Thr Ser 
            20                  25                  30          


Asn Arg Thr Ile Glu Ile Leu Pro Lys Gln Lys Ile Gln Ser Phe Ser 
        35                  40                  45              


Leu Ser Ile Glu Asn Lys Thr Leu Ile Lys Arg Asp Ser Leu Lys Gly 
    50                  55                  60                  


Thr Val Gln Lys Asn Lys Tyr Asp Val Ile Arg Ala Ile Ile Lys Tyr 
65                  70                  75                  80  


Asn Arg Phe Pro Asp Arg Ile Ser Ala Glu Glu Val Leu Pro Phe Leu 
                85                  90                  95      


Asn His Lys Phe Gln Asn Glu Ile Lys Tyr Tyr Asn Asp Asn Lys Leu 
            100                 105                 110         


His Ser Phe Leu Leu Thr Ser Leu Ile Val Glu Ala Val Lys Glu Lys 
        115                 120                 125             


Asn Pro Gln Lys Leu Gln Pro Tyr Phe Asp Trp Glu Glu Trp Tyr Ile 
    130                 135                 140                 


Ser Asn Lys Ser Asn Ala Leu Ile Lys Ser Ile Glu Asn Asn Lys Ile 
145                 150                 155                 160 


Asp Ser Glu Lys Lys Asp Ser Lys Arg Lys Lys Thr Leu Gln Thr Trp 
                165                 170                 175     


Ala Ala Glu Tyr Thr Asp Asn Gly Ser Ile Asp Leu Ser Glu Tyr His 
            180                 185                 190         


Asn Ile Tyr Asp Ile Asp Thr Leu Val Arg Ala Leu Ile Lys Ala Asp 
        195                 200                 205             


Lys Gly Glu Leu Lys Glu Asp Gly Thr Pro Lys Asn Ala Asn Ala Phe 
    210                 215                 220                 


His Arg Asn Leu Lys Arg Thr Leu Gln Asp His Gln Lys Thr Val Phe 
225                 230                 235                 240 


Gly Thr Arg Glu Ala Ser Asn Met Thr Asn Arg Glu Asn Asp Gln Leu 
                245                 250                 255     


Ala Val Tyr His Leu Glu Val Val Lys Tyr Leu Glu His Tyr Phe Ser 
            260                 265                 270         


Val Lys Ser Thr Gln Arg Arg Asn Thr Arg Ala Asp Ile Asp Tyr Tyr 
        275                 280                 285             


Leu Lys Ala Glu Thr Ile Lys Asn Ile Ile Thr Lys Gln Leu Leu Asn 
    290                 295                 300                 


Ala Val Arg Asn Tyr Leu Leu Gln Gln Gly Lys Ala Gln His His Lys 
305                 310                 315                 320 


Phe Ala Glu Ile Lys Pro Asp Ser Asn Ser Leu Thr Glu Ile Lys Arg 
                325                 330                 335     


Asn Glu Ala Phe Val Leu Asn Met Ile Asp Ala Cys Gly Phe Ala Ala 
            340                 345                 350         


Asn Asn Ile Arg Asn Ile Val Asp Ala Glu Gln Ile Asn Asp Ile Leu 
        355                 360                 365             


Ser Lys Lys Glu Tyr Val Gln Ser Leu Asp Ser Asn Arg Val Asn Asn 
    370                 375                 380                 


Gln Leu Phe Lys Phe Phe Phe Gly Thr Asp Leu Pro Glu Thr Ala Thr 
385                 390                 395                 400 


Asp Lys Val Lys Thr Leu Trp Ala Met Arg Gly Ala Val Gln Gln Ile 
                405                 410                 415     


Arg Asn Lys Val Val His Tyr Lys Gln Lys Ala Leu Asp Ala Ile Phe 
            420                 425                 430         


Asn Val Thr Asp Phe Glu Tyr Pro Ser Phe Asn Asn Ser Ile Tyr Thr 
        435                 440                 445             


Asp Thr Ile Tyr Lys Asp Cys Leu Glu Thr Glu Leu Gln Lys Leu Pro 
    450                 455                 460                 


Glu Ala Phe Ala Gln Gln Leu Lys Thr Gly Gly Ala Leu Thr Tyr Tyr 
465                 470                 475                 480 


Pro Phe Asp Asp Leu Lys Thr Leu Leu Asn Lys Val Ala Phe Ser Leu 
                485                 490                 495     


Cys Arg Ser Val Val Pro Phe Ala Pro Gly Phe Lys Lys Val Gln Lys 
            500                 505                 510         


Gln Gly Gln Asn Tyr Gln Asn Ala His Lys Glu Asn Phe Tyr Asn Leu 
        515                 520                 525             


Asp Leu Lys Ser Tyr Leu Pro Lys Glu Lys Phe Asp Glu Glu Ala Tyr 
    530                 535                 540                 


Asn Ala Arg Tyr Phe Leu Leu Lys Leu Ile Tyr Asn Asn Leu Phe Leu 
545                 550                 555                 560 


Ser Asp Phe Thr Gly Asn Arg Glu Gln Phe Ser Ala Thr Val Asn Tyr 
                565                 570                 575     


Ile Leu Lys Arg Asn Lys Lys Gln Ala Glu Asn Ser Arg Arg Pro Lys 
            580                 585                 590         


Ala Tyr Ala Phe Glu Ala Val Arg Gln Met Lys Lys Glu Glu Ser Ile 
        595                 600                 605             


Thr Ser Tyr Met Ala Tyr Ala Gln Asn Gln Leu Met Val Glu Lys Asn 
    610                 615                 620                 


Lys Lys Glu Asp Asp Lys Pro Glu Asp Ile Arg Ile Asn Phe Glu Lys 
625                 630                 635                 640 


Phe Val Leu Gln Val Phe Ile Lys Gly Phe Asp Asp Phe Leu Leu Asn 
                645                 650                 655     


Glu Lys Phe Lys Phe Ile Ala Thr Pro Cys Phe Gln Leu Ser Lys Glu 
            660                 665                 670         


Asn Thr Lys Gln Gln Gln Ala Asp Val Leu Asn Gln Phe Glu Gln Arg 
        675                 680                 685             


Ile Ile Lys Glu Cys Arg Phe Gln Ser His Thr Ile Lys Ala Glu Glu 
    690                 695                 700                 


Ala Lys His Val Ala Phe Phe Thr Phe Cys Lys Leu Leu Asp Ala Thr 
705                 710                 715                 720 


His Leu Ser Asn Leu Arg Asn Glu Leu Ile Lys Phe Lys Gln Ser Ser 
                725                 730                 735     


Lys Gln Phe Glu Leu Cys His Val Leu Glu Ile Ile Glu Leu Ser Leu 
            740                 745                 750         


Leu Asn Ala Asp Val Val Pro Ala Asp Tyr Arg Glu Leu Tyr Ala Asn 
        755                 760                 765             


Lys Val Thr Cys Leu Asn Arg Val Arg Pro Phe Ile Ala Asp Gly Val 
    770                 775                 780                 


Asp Ile Thr Lys Trp Ser Gly Leu Phe Ile Gln Thr Asp Asn Glu Thr 
785                 790                 795                 800 


Pro Val Ile His Ala Asn Val Glu Leu Thr Val Lys Tyr Gly Thr Thr 
                805                 810                 815     


Lys Leu Leu Glu Gln Leu Ile Ala Lys Gly Ala Ser Phe Lys Leu Ser 
            820                 825                 830         


Glu Ser Asp Phe Asn Leu Trp Asn Ser Ala Lys Asp Thr Ile Lys Glu 
        835                 840                 845             


Val Ile Asn Lys Arg Leu Ser Leu His Lys Gln Trp Glu Asp Ala Ile 
    850                 855                 860                 


Arg Lys Asp Lys Glu Glu Lys Asn Lys Arg Val Lys Thr Arg Ser Asn 
865                 870                 875                 880 


Phe Ala Gln Gln Phe Ile Asn Lys Glu Arg Asp Ser Tyr Phe Asp Leu 
                885                 890                 895     


Cys Asp Tyr Ile Asp Ala Tyr Asn Trp Tyr Asp Ser Lys Leu His Phe 
            900                 905                 910         


Val Asn Leu Ile Arg Leu His His Leu Thr Ile Asp Ile Leu Gly Arg 
        915                 920                 925             


Met Val Gly Phe Val Ala Ile Trp Glu Arg Asp Phe Gln Tyr Met Thr 
    930                 935                 940                 


Glu Ser Ile Ser Pro Met Asn Ser Ser Lys Glu Leu Asp Phe Thr Lys 
945                 950                 955                 960 


Gly Phe Pro Leu Leu Lys Gly Ile Gln Leu Asp Tyr Tyr Lys Arg Ile 
                965                 970                 975     


Phe Leu Ser Gly Asn Tyr Arg Asp Ile Arg Asn Tyr Ile Ala His Phe 
            980                 985                 990         


Asn Tyr Leu Thr Asp Ser Lys Phe  Ser Met Ile Asp Leu  Ile Asn Glu 
        995                 1000                 1005             


Leu Arg  Glu Leu Leu Ser Tyr  Asp Arg Lys Leu Lys  Asn Ala Val 
    1010                 1015                 1020             


Asn Lys  Ala Phe Ile Asp Leu  Phe Asp Lys Gln Gly  Met Val Leu 
    1025                 1030                 1035             


Lys Leu  Lys Leu Asn Asp Ala  His Arg Phe Glu Ile  Glu Ser Val 
    1040                 1045                 1050             


Glu Pro  Lys Leu Leu Tyr His  Leu Gly Thr Thr Pro  Ala Arg Asp 
    1055                 1060                 1065             


Pro Ile  Ser Thr Tyr Gln Val  Lys Pro Gln Tyr Cys  Asp Met Cys 
    1070                 1075                 1080             


Lys Ala  Leu Leu Glu Ile Lys  Asn Ser Ser Arg Leu  Asn Asn Val 
    1085                 1090                 1095             


Ile Ile  Ser Leu 
    1100         


<210>  1005
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1005

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Tyr Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  1006
<211>  1432
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1006

Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser Val Thr 
1               5                   10                  15      


Glu Asn Lys Asn Glu Glu Gln Leu Ser Arg Gln Ser Leu Leu Tyr Tyr 
            20                  25                  30          


Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp Leu Glu 
        35                  40                  45              


Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr Asn Val 
    50                  55                  60                  


Ile Thr Pro Glu Ile Asp Leu Cys Lys Glu Glu Asn Arg Glu Trp Ile 
65                  70                  75                  80  


Val Glu Asp Leu Thr Lys Asn Phe Asn Ala Val Ile Asn Asn Ala Leu 
                85                  90                  95      


Arg Ser Ile Lys Asn Pro Lys Glu Lys Arg Glu Glu Arg Val Glu Lys 
            100                 105                 110         


Glu Val Ala Phe Ile Leu Asn Leu Asn Lys Asn Ser Ile Lys Ile Lys 
        115                 120                 125             


Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe Ser Ala 
    130                 135                 140                 


Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser Lys Glu 
145                 150                 155                 160 


Glu Ala Tyr Ile Arg Glu Met Ile Ser Asn Leu Val Leu Arg Lys Leu 
                165                 170                 175     


Lys Lys Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Cys Lys Met 
            180                 185                 190         


Gln Met Thr Glu Ile Thr Ile Ser Leu Met Ser Ala Ile Cys Leu Tyr 
        195                 200                 205             


Gly Asn Val Glu Ser Phe Asp Pro Val Ile Leu Lys Ala Phe Phe Glu 
    210                 215                 220                 


Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile Val 
225                 230                 235                 240 


Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys Asp 
                245                 250                 255     


Gly Lys His Leu Leu Ile Pro Ala Asn Ala Asp His Arg Lys Lys Lys 
            260                 265                 270         


Tyr Val Phe Glu Phe Met Arg Lys Tyr Ala Ala Ala Glu Glu Lys Glu 
        275                 280                 285             


Lys Arg Glu Ile Thr Glu His Ile Gln Asn Leu Ile Gly Leu Tyr Leu 
    290                 295                 300                 


Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asn Met 
305                 310                 315                 320 


Thr Glu Ser His Asn Cys Ile Ser Gly Glu Ile Glu Glu Ile Phe Asn 
                325                 330                 335     


Glu Ile Glu Glu Leu Glu Asn Ser Ser Lys Gln Lys Arg Glu Glu Lys 
            340                 345                 350         


Lys Lys Thr Arg Glu Glu Leu Asp Lys Ile Gln Glu Ser Arg Lys Gly 
        355                 360                 365             


Asn Lys Arg Asn Thr Asn Ser Asn Asn Gln Asn Tyr Lys Asn Asn Lys 
    370                 375                 380                 


Thr Asp Ser Asp Lys Lys Glu Asn Gln Ala Asp Ala Asn Glu Asn Lys 
385                 390                 395                 400 


Leu Lys Glu Asn Glu Leu Arg Asp Lys Arg Arg Arg Leu Ser Lys Glu 
                405                 410                 415     


Leu Glu Asn Leu Asp Ser Glu Val Arg Ile Lys Lys Glu Lys Leu Lys 
            420                 425                 430         


Asn Thr Thr Val Lys Glu Met Ala Leu Lys Tyr Arg Ala Ala Val Asn 
        435                 440                 445             


Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile Lys Glu 
    450                 455                 460                 


Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr Ile Asp 
465                 470                 475                 480 


Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp Arg Tyr 
                485                 490                 495     


Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu Trp Thr 
            500                 505                 510         


Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val Tyr His 
        515                 520                 525             


Phe Ala Ile Pro Asp Leu Ser Gly Ala Leu Glu Gly Glu Ser Val Ser 
    530                 535                 540                 


Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly Phe Asp 
545                 550                 555                 560 


Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met Glu Lys 
                565                 570                 575     


Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr Pro Glu 
            580                 585                 590         


Glu Glu Arg Glu Lys Pro Gly His Glu Asp Val Leu Leu Met Lys Thr 
        595                 600                 605             


Leu Ser Glu Ile Glu Glu Ser Gln Thr Glu Glu Glu Arg Gln Lys Lys 
    610                 615                 620                 


His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp Ala Asp 
625                 630                 635                 640 


Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg Lys Lys 
                645                 650                 655     


Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr Lys Glu 
            660                 665                 670         


Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His Tyr Thr 
        675                 680                 685             


Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Glu Leu Thr Glu Tyr 
    690                 695                 700                 


Phe Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg Glu Lys 
705                 710                 715                 720 


Tyr Tyr Thr Asn Asn Val Trp Lys Tyr Tyr Asp Ile Glu Val Ile Asn 
                725                 730                 735     


Asn Ile Met Gly Lys Ile Tyr Cys Gly Arg Lys Tyr Arg Ala Ala Gln 
            740                 745                 750         


Val Pro Ala Phe Asn Asn Ile Ile Ser Arg Pro Ala Leu Pro Gln Leu 
        755                 760                 765             


Met Asp Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met Asn Cys 
    770                 775                 780                 


Pro Asp Arg Asp Val Ile Lys Lys Tyr Trp Ser Ser Leu Phe Phe Val 
785                 790                 795                 800 


Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Glu Lys Pro 
                805                 810                 815     


Glu Asp Asn Ile Lys Glu Arg Phe Phe Arg Ala Met Glu Lys Glu Ser 
            820                 825                 830         


Gly Gln Ala Lys Asp Gly Lys Glu Gln Lys Ala Trp Glu Ser Phe Glu 
        835                 840                 845             


Asn Arg Ile Asp Gln Ile Gly Arg Glu Arg Ser Phe Gly Ala Ile Cys 
    850                 855                 860                 


Gln Gly Leu Met Val Glu Tyr Met Leu Gln Asn Arg Asp Ile Ser Met 
865                 870                 875                 880 


Val Gln Thr Glu Thr Gly Asp Gly Lys Thr Asn Lys Lys Gln Ile Tyr 
                885                 890                 895     


Lys His Tyr Arg Thr Leu Leu Tyr Ile Cys Ile Arg Ser Ala Phe Thr 
            900                 905                 910         


Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro Val Leu Thr 
        915                 920                 925             


Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ile Asp Gly Leu Lys 
    930                 935                 940                 


His Leu Ser Leu Phe Asp His Leu Lys Glu Thr Phe Asn Asp Ala Glu 
945                 950                 955                 960 


Thr Gly Ser Phe Trp Tyr Met Ala Ala His Phe Ile Asn Gln Lys Tyr 
                965                 970                 975     


Leu Asn His Leu Ile Gly Ser Ile Arg Asn Tyr Leu Gln Phe Thr Glu 
            980                 985                 990         


Asp Ile Glu Asp Arg Ala Leu Ser  Leu Gly Asp Cys Val  Asp Asn Lys 
        995                 1000                 1005             


Arg Glu  Glu Lys Asn Leu Arg  Tyr Arg Asn Thr Leu  Glu Ile Leu 
    1010                 1015                 1020             


Glu Phe  Val Ala Gln Phe Cys  Glu Arg Thr Thr Asn  Val Met Glu 
    1025                 1030                 1035             


Asp Tyr  Phe Glu Ser Asn Gln  Glu Tyr Ala Ala Tyr  Leu Ser Gly 
    1040                 1045                 1050             


Phe Val  Asp Tyr Asn Val Ser  Lys Lys Glu Thr Asp  Ile Glu Lys 
    1055                 1060                 1065             


Ala Leu  Tyr Gly Phe Cys Arg  Gln Lys Phe Lys Val  Asp Gly Lys 
    1070                 1075                 1080             


Glu Tyr  Met Ala Gly Ile Tyr  Tyr Asp Gly Glu Asn  Leu Ile Pro 
    1085                 1090                 1095             


Asn Arg  Asn Ile Ile Arg Ala  Asn Met Tyr Gly Asn  Val Ser Cys 
    1100                 1105                 1110             


Leu Lys  Pro Tyr Met Asp Arg  Ile Thr Leu Lys Glu  Ile Arg Thr 
    1115                 1120                 1125             


Met Tyr  Ala Asp Gln Asn Lys  Leu Asp Thr Val Leu  Lys Glu Gly 
    1130                 1135                 1140             


Val Cys  Arg Thr Glu Glu Glu  Gln Lys Ala Tyr Arg  Glu Tyr Gln 
    1145                 1150                 1155             


Asn Glu  Lys Asn Arg Ile Glu  Leu Phe Asp Leu Cys  Thr Tyr Thr 
    1160                 1165                 1170             


Gln Ile  Leu Asn Asp Met Gln  Ala Arg Leu Ile Gly  Trp Ser Tyr 
    1175                 1180                 1185             


Met Arg  Glu Arg Asp Leu Met  Tyr Tyr Gln Leu Gly  Tyr Tyr Tyr 
    1190                 1195                 1200             


Thr Lys  Leu Phe Trp Thr Asp  Ala Ile Ser Glu Glu  Asp Ala Arg 
    1205                 1210                 1215             


Arg Arg  Leu Val Gly Glu Leu  Val Asn Val Glu Asp  Gly Val Ile 
    1220                 1225                 1230             


Leu Tyr  Gln Ile Leu Ala Phe  Asn Ser Tyr Asn Leu  Pro Ile Ile 
    1235                 1240                 1245             


Ala Asn  Lys Asn Asn Thr Val  Thr Phe Leu Lys Gly  Glu Gly Ser 
    1250                 1255                 1260             


Ile Gly  Gly Lys Ala Ile Thr  Ala Phe Leu Lys Asn  Tyr Glu Asn 
    1265                 1270                 1275             


Ala Glu  Arg Ile Tyr Glu Glu  Ala Leu Asp Leu Phe  Glu Asn Thr 
    1280                 1285                 1290             


Asp Glu  His Ala Ala Ile Ile  Asn Thr Arg Asn Tyr  Ile Glu His 
    1295                 1300                 1305             


Phe Lys  Tyr Phe Ile Lys Ser  Asp Arg Ser Met Met  Asp Leu Tyr 
    1310                 1315                 1320             


Ser Glu  Val Tyr Asp Arg Phe  Phe Arg His Asp His  Asn Arg Lys 
    1325                 1330                 1335             


Lys Asn  Val Pro Asp Ser Leu  Lys Asn Val Leu Ala  Asp Asn Phe 
    1340                 1345                 1350             


Met Ile  Ala Asp Ile Ser Met  Glu Leu Gly Ser Lys  Lys Val Gly 
    1355                 1360                 1365             


Glu Lys  Lys Lys Gly Phe Arg  Glu His Lys Ala Ala  Arg Ile Glu 
    1370                 1375                 1380             


Phe Thr  Asp Lys Gly Ile Arg  Ser Thr Asp Met Thr  Tyr Thr Val 
    1385                 1390                 1395             


Lys Pro  Asp Pro Lys Asp Ser  Lys Lys Asp Glu Lys  Val Leu Val 
    1400                 1405                 1410             


Pro Ala  Arg Ser Glu Val Phe  Leu Lys Gln Phe Gln  Lys Ile Leu 
    1415                 1420                 1425             


Glu Tyr  Arg Ile 
    1430         


<210>  1007
<211>  1184
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1007

Met Arg Val Ser Lys Val Lys Val Leu Gly Asn Glu Glu Thr Lys Gly 
1               5                   10                  15      


Arg Ile Val Leu Met His Arg Ser Pro Val Lys Gly Gln Leu Ile Tyr 
            20                  25                  30          


Ser Glu Asp Ala Gly Lys Arg Asp Arg Thr Glu Asp Ile Ile Pro Glu 
        35                  40                  45              


Gln Lys Leu Glu Ser Phe His Leu Ser Ile Leu Asn Lys Thr Phe Leu 
    50                  55                  60                  


Arg Lys Glu Phe Phe Lys Lys Glu Leu Lys His Glu Ala Lys Lys Asn 
65                  70                  75                  80  


Gly Leu Lys Gly Asp Ala Glu Asp Lys Tyr Ile Ser Glu Lys Leu Lys 
                85                  90                  95      


Glu Tyr His Ser Leu Leu Gln Phe Ile Asp Asp Val Leu Ser Val Lys 
            100                 105                 110         


Tyr Asn Glu Asn Arg Lys Ala Ile Lys Phe Pro Glu Tyr Leu Thr Arg 
        115                 120                 125             


Glu Met Ile Glu Ile Phe Leu Asn His Lys Phe Arg Lys Glu Val Thr 
    130                 135                 140                 


Tyr Thr Asn Lys Asn Gly Ala Ser Val Ser Phe Leu Leu Ser Thr Leu 
145                 150                 155                 160 


Ile Leu Asn Ala Ile Glu Lys His Ser Val Ile Glu Met Gln Pro Phe 
                165                 170                 175     


Val Asp Trp Arg Asn Trp Phe Val Glu Thr Lys Ser Lys Phe Leu Lys 
            180                 185                 190         


Lys Ser Ile Ile Asn Asn Cys Ile Pro Thr Asn Gly Gly Pro Ile Ser 
        195                 200                 205             


Arg Arg Arg Glu Thr Leu Met Lys Trp Arg Asp Asp Tyr Phe Thr Asn 
    210                 215                 220                 


Ala Glu Ile Asp Leu Ala Arg Leu His Lys Lys Phe Gly Thr Asp Thr 
225                 230                 235                 240 


Leu Met Ala Ser Leu Arg Glu Val Pro Gln Thr Glu Lys Ser Gly Asn 
                245                 250                 255     


Glu Tyr His Arg Leu Leu Lys Ser Cys Leu Gln Ser His Gln Lys Lys 
            260                 265                 270         


Leu Phe Gly Lys Arg Ala Glu Gly Tyr Asp Ile Asn Arg Ala Asp Asn 
        275                 280                 285             


Gln Leu Tyr Val Tyr Asn Thr Glu Val Val Lys Tyr Met Glu His Tyr 
    290                 295                 300                 


Phe Pro Val Lys Ser Ser Lys Arg Arg Asn Ser Thr Ala Glu Ile Lys 
305                 310                 315                 320 


Tyr Tyr Leu Gln Thr Asp Thr Ile Lys Cys Cys Leu His His Gln Ile 
                325                 330                 335     


Ile Asn Ala Val Arg Gly Leu Ala Leu Arg Glu Gly Lys Phe Asn Leu 
            340                 345                 350         


His Gly Phe Asp Asp Lys Leu Ile Pro Asn Glu Arg Asn Val Ser Ser 
        355                 360                 365             


Ser Ile Leu Asn Glu Leu Lys Thr Ser Glu Gly Phe Val Leu Asn Met 
    370                 375                 380                 


Leu Gly Gly Cys Ala Phe Ala Ala Asn Cys Leu Arg Asn Ile Val Asp 
385                 390                 395                 400 


Ala Thr Gln Arg Ser Asp Leu Leu Gly Phe Arg Cys Phe Glu Val Ser 
                405                 410                 415     


Leu Lys Lys Gly Lys Ser Asn Ser Asp Leu Phe Ala Leu Phe Phe Gly 
            420                 425                 430         


Phe Gly Arg Glu Asp Met Asp Asp Asp Ser Glu Trp Glu Lys His Leu 
        435                 440                 445             


Tyr Ala Ala Arg Tyr Ser Val Ser Glu Ile Arg Asn Arg Val Ala His 
    450                 455                 460                 


Tyr His Lys Ser Ala Ile Glu Asn Ile Tyr Asn Ile Thr Asp Phe Glu 
465                 470                 475                 480 


Tyr Arg Glu Asn Ser Met Cys Ser Tyr Thr Asp Thr Lys Phe Thr Thr 
                485                 490                 495     


Ala Leu Gln Asn Glu Ile Tyr Asn Thr Pro Lys Ala Phe Ser Leu Gln 
            500                 505                 510         


Leu Met Thr Gly Lys Val Leu Glu Tyr Tyr Pro Lys Glu Lys Leu Val 
        515                 520                 525             


Ser Phe Phe Gln Lys Tyr Lys Phe Ser Leu Tyr Arg Ser Val Val Pro 
    530                 535                 540                 


Phe Ala Pro Gly Phe Lys Asn Ile Met Arg Thr Gly Val Asn Tyr Gln 
545                 550                 555                 560 


Asn Ala Thr Gln Asn Arg Leu Phe Tyr Asp Met Gly Leu Thr Ala Phe 
                565                 570                 575     


Gln Asp Lys Asp Arg Tyr Ile Asp Asp Val Glu Ala Trp Asn Ala Arg 
            580                 585                 590         


Tyr Phe Phe Met Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Arg Phe 
        595                 600                 605             


Thr Asn Asp Lys Asn Asp Leu Phe Arg Lys Thr Val Glu Gln Val Leu 
    610                 615                 620                 


Glu Val Asn Arg Ser His Met Glu Lys Val Gly Lys Asp Asp Arg Gln 
625                 630                 635                 640 


Ala Phe Gly Glu Val Arg Gln Met Arg Glu Asn Glu Thr Ala Asn Asp 
                645                 650                 655     


Tyr Met Ala Tyr Leu Gln Ser Ser Leu Arg Met Glu Lys Asn Lys Lys 
            660                 665                 670         


Glu Leu Glu Gly Asn Gly Ala Lys Arg Ile Asn Phe Glu Lys Phe Ile 
        675                 680                 685             


Leu Gln Met Phe Val Lys Gly Phe Asp Ser Phe Leu Lys Asp Gly Ala 
    690                 695                 700                 


Phe Glu Phe Val His Ser Pro Glu Asn Cys Leu Thr Gly Ser Thr Glu 
705                 710                 715                 720 


Lys Glu Arg Ala Lys Glu Arg Asn Ser Leu Cys Glu Glu Ile Gly Asn 
                725                 730                 735     


Tyr Val Arg Leu Val Ser Thr Val Ile Asp Pro Gly Lys Gly Ser His 
            740                 745                 750         


Val Ala Phe Tyr Val Phe Cys Lys Met Leu Asn Ser Val Tyr Leu Ser 
        755                 760                 765             


Asn Ile Arg Asn Glu Met Ile Lys Tyr His Lys Val Val Arg Thr Asp 
    770                 775                 780                 


Glu Leu Ala His Leu Ile Glu Ile Ile Glu Leu Cys Leu Leu Ser Ala 
785                 790                 795                 800 


Asp Ala Val Ser Gln Lys Thr Val Asn Ala Asp Lys Leu Ser His Phe 
                805                 810                 815     


Phe Ala Glu Gly Val Asn Val Asp Asp Asp Glu Asn Val Ile His Ala 
            820                 825                 830         


Ser Met Glu Thr Phe Arg Lys Tyr Gly Thr Arg Asp Leu Phe His Lys 
        835                 840                 845             


Leu Met Leu Gln Asp Asp Arg Phe Leu Val Ser Ser Asp Asp Tyr Arg 
    850                 855                 860                 


Glu Trp Glu Glu Met Lys Glu Lys Ile Glu Gly Lys Val Lys Gln Arg 
865                 870                 875                 880 


Glu Leu Leu His Ala Glu Trp Cys Glu Ala Lys Glu Lys Asp Lys Lys 
                885                 890                 895     


Ser Arg Lys Val Lys Ser Asn Ser Arg Thr Cys Phe Glu Lys Lys Phe 
            900                 905                 910         


Met Gly Ala Lys Ala Glu Glu Tyr Tyr Ser Leu Cys Asn Val Ile Asp 
        915                 920                 925             


Lys Tyr Asn Trp Leu Asp Asn Lys Leu His Leu Val His Leu Asn Lys 
    930                 935                 940                 


Leu His Asn Leu Val Ile Glu Ile Leu Gly Arg Met Val Gly Phe Thr 
945                 950                 955                 960 


Ala Leu Phe Glu Arg Asp Phe Gln Tyr Ile Cys Lys Ser Asp Ser Glu 
                965                 970                 975     


Tyr Glu Gln Leu Tyr Asn Leu Asp Phe Asn Met Gly Leu Pro Lys Phe 
            980                 985                 990         


Lys Asn Ser Ile Lys Gly Ser Gly  Lys Ala Lys Asn Ser  Thr Gln Asn 
        995                 1000                 1005             


Ile Asp  His Asn Ala Thr Gly  Ile Gly Asn Ser Ser  Asn Leu Leu 
    1010                 1015                 1020             


Lys Glu  Asn Ser Asn Gly Thr  His Tyr Cys Lys Asn  Leu Ser Gly 
    1025                 1030                 1035             


Asp Gly  Val Glu Asp Lys Leu  Lys Arg Leu Phe Leu  Tyr Asp Asp 
    1040                 1045                 1050             


Tyr Arg  Asn Val Arg Asn Phe  Val Ala His Phe Asn  Tyr Leu Thr 
    1055                 1060                 1065             


Arg Val  Glu Asp Asp Leu Gly  Gly Asn Asp Ala Val  Lys Leu Ser 
    1070                 1075                 1080             


Gly Thr  Arg Tyr Ser Leu Ile  Glu Leu Ile Asn Glu  Leu Arg Asn 
    1085                 1090                 1095             


Leu Leu  Lys Tyr Asp Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ser 
    1100                 1105                 1110             


Phe Ile  Asp Met Phe Glu Arg  His Gly Met His Val  Lys Met Lys 
    1115                 1120                 1125             


Leu Asn  His Asn His Lys Leu  Phe Val Asp Ser Ile  Ser Pro Arg 
    1130                 1135                 1140             


Lys Ile  Lys His Leu Gly Gly  Gly Tyr Lys Lys Arg  Gly Lys Asp 
    1145                 1150                 1155             


Asp Lys  Met Tyr Val Gln Thr  Thr Asn His Val Asp  Pro Leu Tyr 
    1160                 1165                 1170             


Cys Asp  Met Cys Arg Ala Leu  Leu Glu Met Lys 
    1175                 1180                 


<210>  1008
<211>  1315
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1008

Met Ile Ile Ile Lys Lys Phe Gly Arg Ser Val Ile Thr Gln Asp Lys 
1               5                   10                  15      


Asn Thr Asp Asn Lys Arg Glu Arg Glu Leu Asp Thr Ser Ala Arg Ala 
            20                  25                  30          


Lys Ala Lys Ser Gln Asn Ser Gln Val Phe Pro Phe Leu Asn Lys Lys 
        35                  40                  45              


Glu Asp Phe Ile Asn Leu Trp Ile Ser Glu Phe Asp Lys Leu Ile Tyr 
    50                  55                  60                  


Lys Pro Lys Gly Asp Asp Lys Pro Thr Lys Glu Met Tyr Thr Leu Arg 
65                  70                  75                  80  


Glu Ala Ala Gly Lys Gly Phe Leu Asn Tyr Trp Asn Gln Met Pro Met 
                85                  90                  95      


Val Ser Lys Lys Asp Gly Ala Phe Ser Asp Met Trp Met Ser Lys Val 
            100                 105                 110         


His Pro Tyr Gly Arg Gly Ile Thr Glu Phe Ser Pro Pro Leu Gln Leu 
        115                 120                 125             


Glu Lys Leu Ile Asp Gln Gly Leu Leu Ser Ala Met Gly Gly Ser Glu 
    130                 135                 140                 


Pro Leu Lys Asn Cys His Trp Asn Arg Val Thr Ser Asn Val Phe Lys 
145                 150                 155                 160 


Gly Leu Lys Val Gln Leu Asp Ile Leu Glu Ala Gln Ala Lys Asn Thr 
                165                 170                 175     


Phe Val Ile Lys Asn Lys Thr Asn Ser Lys Arg Asn Arg Pro Ala Ser 
            180                 185                 190         


Gln Asn Ile Lys Glu Phe Leu Leu Thr Asp Glu Thr Ala Phe Ile Asn 
        195                 200                 205             


Leu Trp Ile Ser Glu Phe Asp Lys Leu Ile Leu Lys Pro Gln Gly His 
    210                 215                 220                 


Asn Lys Pro Thr Glu Lys Met Tyr Asn Leu Arg Gln Gln Ala Gly Val 
225                 230                 235                 240 


Ala Phe Leu Asn Tyr Trp Lys Lys Lys Pro Leu Ile Pro Trp Ala Asn 
                245                 250                 255     


Ser Glu Ser Phe Pro Asp Lys Trp Met Leu Lys Val His Pro Tyr Gly 
            260                 265                 270         


Asp Lys Thr Ser Asn Asn Arg Ser Glu Thr Leu Ile Lys Ser Lys Trp 
        275                 280                 285             


Gly Ser Val Met Arg Ala Lys Glu Cys Leu Ser Asp Asp Gln Trp Glu 
    290                 295                 300                 


Gln Val Ala Phe Asn Val Tyr Ser His Leu Tyr Gly Asn Gln Lys Thr 
305                 310                 315                 320 


Leu Asn Gly Lys Asn Lys Glu Ile Gly Leu Ile Ala Ala Arg Ala Asn 
                325                 330                 335     


Ser Ile Lys Gln Asn Val Pro Ser Tyr Thr Leu Asp Lys Asp Asn Asn 
            340                 345                 350         


Phe Leu Ser Asp Lys Lys Asp Lys Leu Arg Tyr Ile Ala Ala Leu Arg 
        355                 360                 365             


Gly Glu Gly Ile Lys Trp Glu Glu Val Lys Asp Arg Tyr Lys Trp Lys 
    370                 375                 380                 


Glu Leu Thr Gln Leu Ile Asn Ile Glu Glu Ile Asp Ser Thr Asp Ile 
385                 390                 395                 400 


Ala Lys Arg Lys Gln His Leu Ala Glu Cys Phe Tyr Thr His His Gly 
                405                 410                 415     


Arg Ile Phe Gly Asp Ile Gln Asn Ser Lys Ile Glu Asp Lys Asp Cys 
            420                 425                 430         


Phe Leu Tyr His Ser Leu Val Lys Glu Ile Leu Phe Glu Cys Ile Glu 
        435                 440                 445             


Lys Lys Gln Asp Phe Leu Asn Asp Thr Glu Val His Gln Arg Leu Ile 
    450                 455                 460                 


Tyr Lys Glu Asn Asn Arg Ile Met Ala Thr Ala Val Ser Ile Gly Lys 
465                 470                 475                 480 


Leu Ile His Tyr Gln Gly Gly Ile Glu Ala Ile Gly Asn Lys Glu Asp 
                485                 490                 495     


Leu Val Asn Ser Lys Phe Leu Thr Asp Ala Gly Leu Thr Glu Ile Lys 
            500                 505                 510         


Gln Asn Glu Ser Phe Val Arg Gln Trp Leu Glu Leu Ile Ala Ile Ala 
        515                 520                 525             


Asn Thr Thr Leu Ser Gln Leu Val Asp Pro Asp Gly Lys His Glu Asp 
    530                 535                 540                 


Ile Phe Ala Ala Thr Ser Phe Asp Asp Ala Leu Lys Gly Leu Asn Asn 
545                 550                 555                 560 


Ile Ser Asp Phe Asp Ser Lys Phe Lys Leu Leu Phe Gly Glu Asn His 
                565                 570                 575     


Arg Leu Tyr Asp Asp Asp Thr Glu Arg Gln Lys Leu Leu Arg Ile Ile 
            580                 585                 590         


Tyr Asp Thr Ile Ser Ala Leu Arg Asn Ala Ser Phe His Phe Lys Asn 
        595                 600                 605             


Ile Gln Gly Phe Asn Lys Ala Leu Glu Asp Asn Leu Ser Thr Lys Gly 
    610                 615                 620                 


Arg Arg Gln Lys Gly Val Val Asp Lys Ile Ile Glu Tyr Thr Lys Val 
625                 630                 635                 640 


His Gln Gln Lys Gln His Glu Leu Leu Ile Ala Asp Leu Lys Ala Ala 
                645                 650                 655     


Asn Val Glu Asp Tyr Leu Ser Gln Leu Gln Leu Asp Tyr Leu Phe Glu 
            660                 665                 670         


Val Val Cys Lys Gly Glu Arg Glu Leu Leu Asp Met Pro Lys Phe Ser 
        675                 680                 685             


Lys Leu Leu Leu Arg Ala Gly Glu Ile Gly Glu Lys Ile Ile Ser Pro 
    690                 695                 700                 


Val Asn Ala Thr Ala Met Glu His Pro Ala Tyr Gln Cys Cys Phe Ile 
705                 710                 715                 720 


Ser Leu Lys Met Leu Tyr Asp Gln Asp Phe Val Asn Trp Leu Lys Lys 
                725                 730                 735     


Gln Ser Asn Lys Asn Ile Ala Ser Trp Met Asp Ser Ala Lys Thr Arg 
            740                 745                 750         


Ala Thr Asn Ala Ala Lys Lys Ile Phe Arg Asn Gly Thr Asn Ile Ser 
        755                 760                 765             


Ser Lys Met Ala Arg Leu Arg Asn Ile Val Glu Asp Glu Thr Leu Val 
    770                 775                 780                 


Glu Tyr Phe Ser Phe Ile Thr Ala Glu Thr Ala Asn Glu Phe Gln Val 
785                 790                 795                 800 


Gln Gln Gln Lys Asn Arg Tyr Gln Ser Asn Ser Ala Ser Ala Lys Glu 
                805                 810                 815     


Gln Ser Asn Phe Val Glu Gln Phe Lys Gln Asp Phe Leu Ile Tyr Ala 
            820                 825                 830         


Phe Lys Gly Tyr Ile Gly Asp Ile Lys Phe Gly Lys Leu Asp Gln Gly 
        835                 840                 845             


Glu Lys Leu Leu Lys Cys Asn Ala Lys Gly Ser Leu Leu Pro Glu Asn 
    850                 855                 860                 


Asn Arg Ser Asp Thr Gly Ala Glu Asp Ile Glu Arg Pro Trp Leu Tyr 
865                 870                 875                 880 


Leu Val Leu His Leu Val Pro Ile Glu Val Val Asn Arg Ile Thr Leu 
                885                 890                 895     


Gln Ile Lys Lys His Ser Val Leu Thr Asn Ser Thr Leu Asp Asp Thr 
            900                 905                 910         


Arg Ala Ala Tyr Thr Asp Ile His Gln Ala Phe Ser Leu Tyr Leu Gly 
        915                 920                 925             


Val His Gly Ala Ile Leu Gly Leu Gln Ser Leu Ser Asn Glu Pro Glu 
    930                 935                 940                 


Leu Gln Val Phe Phe Glu Lys Glu Ser Asp Phe Asn Asn Leu Phe Thr 
945                 950                 955                 960 


Asp Asn Gly Glu Gly Leu Val Pro Val Lys Gly Leu Arg Asp Ile Leu 
                965                 970                 975     


Arg Phe Gly Asn Leu Glu Gln Leu Lys Lys Met Phe Ser Asp Lys Lys 
            980                 985                 990         


Val Ala Ser Asp Asp Ile Thr Asn  Leu Lys Glu Tyr Leu  Glu Ala Thr 
        995                 1000                 1005             


Gly Gly  Lys Ser Lys Ile Ala  Arg Ala Gln Glu Lys  Arg Ile Glu 
    1010                 1015                 1020             


Leu His  Lys Thr Leu Thr Glu  Leu Pro Lys Arg Leu  Thr Lys Pro 
    1025                 1030                 1035             


Arg Val  Lys Gln Thr Gly Ile  Asp Thr Tyr Glu Lys  Asn Asn Asn 
    1040                 1045                 1050             


Ile Ser  Ile Ser Gly Ser Ile  Ser Glu Tyr Arg Lys  Asp Leu Lys 
    1055                 1060                 1065             


Cys Ile  Val Ser Tyr Arg Glu  Leu Lys Asn Lys Ile  Tyr Leu Tyr 
    1070                 1075                 1080             


Asn Val  Lys Gln Ala His Gln  Leu Ile Met Ala Thr  Gln Ala Arg 
    1085                 1090                 1095             


Leu Leu  Gly Tyr Ser Gln Ile  Arg Glu Arg Asp Leu  Tyr Phe Val 
    1100                 1105                 1110             


Leu Leu  Thr Gln Leu Met Leu  Arg Gly Val Thr Leu  Glu Lys Glu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Asp Lys Asp  Lys Leu Asn Ala Leu  Asp Thr Asp 
    1130                 1135                 1140             


Thr Val  Leu Asp Glu Glu Glu  Lys Lys Lys Leu Glu  Lys Gln Ile 
    1145                 1150                 1155             


Lys Pro  Glu Arg Ser Leu Lys  Asp Leu Val Glu Lys  Gly Leu Ile 
    1160                 1165                 1170             


Phe Leu  Ala Leu Asp Gln Leu  Ser Ser Ser Asp Lys  Asp Leu Lys 
    1175                 1180                 1185             


Ala Ile  His Ser Glu Ile Glu  Asp Met Phe Val Gly  Val Ser Pro 
    1190                 1195                 1200             


Asp Ser  Asp Asn Arg Asn Leu  Arg Asn Arg Leu Ala  His Phe Lys 
    1205                 1210                 1215             


Asp Leu  Gly Asn Lys Asn Leu  Ile Asn Ile Thr Ser  Gln Ile Asn 
    1220                 1225                 1230             


Glu Val  Arg Lys Met Met Ser  Tyr Asp Arg Lys Leu  Lys Asn Ala 
    1235                 1240                 1245             


Val Ser  Lys Ser Met Ile Asp  Leu Phe Glu Arg Tyr  Asn Leu Ile 
    1250                 1255                 1260             


Leu Ser  Phe Lys Val Gln Ser  His Lys Leu Gln Leu  Lys Asn Leu 
    1265                 1270                 1275             


Lys Ser  Lys Gln Ile Thr His  Leu Asn Asn Lys Gly  Ile Thr Glu 
    1280                 1285                 1290             


Asn Leu  Leu Ser Asp Asp Tyr  Val Ser Val Ile Lys  Arg Leu Leu 
    1295                 1300                 1305             


Leu Thr  Glu Gln Asn Pro Glu  
    1310                 1315 


<210>  1009
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1009

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Glu Phe Phe Ser Asn Lys Val Leu Tyr Leu Lys Asp Gly Ile Leu 
65                  70                  75                  80  


Tyr Leu Lys Asp Arg Arg Glu Lys Asn Gln Leu Gln Asn Lys Asn Tyr 
                85                  90                  95      


Ser Glu Gln Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Leu Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Asn Asp Phe Glu Lys Lys Phe Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Leu Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Ile Glu Lys Val Glu Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Phe Tyr Asn Tyr Tyr Lys Asp Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Ile Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Tyr Ile Glu 
        195                 200                 205             


Asn Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ser Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Met 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asn Val Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Ser Lys Glu Lys Leu Asn Asp Glu 
        275                 280                 285             


Asn Ile Lys Tyr Val Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Ser Phe Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asn Phe Ile 
        355                 360                 365             


Val Gly Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Thr Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Ile Lys Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Ile Ser Gly Glu Ile Asp Lys Leu Tyr Asp 
            420                 425                 430         


Asn Asn Lys Gln Asn Glu Val Lys Lys Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Ser Lys Asn Glu Ile Glu Asp Phe Phe Ser 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Thr Phe Lys Asn Ile Val 
                485                 490                 495     


Pro Ser Gln Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Thr Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Ser Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ile Lys Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Lys Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Lys Ile Leu Lys Tyr Thr Glu Ser Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Ala Phe Ser Asp Gln Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Val Lys Asp Asn Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Lys 
        915                 920                 925             


Lys Tyr Glu Lys Ala Ile Arg Asn Ile Gln Gln Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Ser Leu Leu Leu 
945                 950                 955                 960 


Arg Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Asp 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Asn Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asp  Met Glu Lys Ile Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Glu Leu  Lys Lys Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  Asn Ala Glu Val Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Lys Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Glu Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Lys  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  1010
<211>  1397
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1010

Met Gly Asn Leu Phe Gly His Lys Lys Trp Tyr Lys Ala Asp Lys Ile 
1               5                   10                  15      


Ile Lys Asp Lys Lys Gly Lys Glu Ser Thr Ile Lys Gln Glu Val Arg 
            20                  25                  30          


Ile Lys Arg Asn Tyr Ser Val Asp Arg Tyr Thr Leu Asn Thr Asn Asn 
        35                  40                  45              


Lys Glu Lys Asn Asn Ile Asn Asn Glu Asp Phe Val Asn Gln Phe Ile 
    50                  55                  60                  


Glu Tyr Lys Thr Asn Asn Asp Ile Leu Lys Lys Phe Thr Lys Lys Phe 
65                  70                  75                  80  


His Met Gly Asn Ile Leu Phe Lys Leu Lys Ala Glu Glu Ser Val Lys 
                85                  90                  95      


Glu Ile Arg Asn Tyr Asn Asp Phe Leu Glu Lys Glu Lys Ala Ile Leu 
            100                 105                 110         


Glu Ile Glu Ile Tyr Gln Gln Ser Glu Glu Leu Arg Lys Lys Glu Asn 
        115                 120                 125             


Ile Thr Lys Lys Asp Ile Ile Asn Lys Val Ile Asn Asp Gly Ile Thr 
    130                 135                 140                 


Glu Asp Ser Asn Glu Ile Asn Met Lys Ile Lys Thr Lys Lys Asn Asn 
145                 150                 155                 160 


Phe Glu Glu Ile Arg Ile Ile Ile Asn Asn Glu Ser Glu Glu Tyr Tyr 
                165                 170                 175     


Ile Lys Leu Arg Ser Leu Asn Asn Asn Glu Leu Asn Leu Lys Arg Glu 
            180                 185                 190         


Ile Tyr Glu Val Leu Lys Ser Ile Asn Ala Asn Leu Tyr Thr Phe Thr 
        195                 200                 205             


Lys Asn Ala Ile Asp Asp Thr Asp Phe Lys Lys Arg Asn Tyr Glu Asn 
    210                 215                 220                 


Phe Leu Arg Glu Asn Met Met Lys His Leu Lys Lys Asn Ile Lys Glu 
225                 230                 235                 240 


Lys Tyr Glu Ile Thr Phe Phe Lys Ser Leu Ser Asn Ser Leu Lys Lys 
                245                 250                 255     


Ile Gln Gly Asn Ile Lys Lys Asn Asp Glu Ile Ile Asn Phe Ile Lys 
            260                 265                 270         


Tyr Tyr Ser Asn Ile Asn Gly Ser Lys Thr Val Ser Glu Asn Lys Lys 
        275                 280                 285             


Lys Phe Leu Glu Lys Ile Leu Asn Thr Glu Val Ser Ile Ser Glu Asn 
    290                 295                 300                 


Asp Ile Ile Asp Phe Ile Ile Gly Glu Leu Lys Phe Phe Gly Ile Ile 
305                 310                 315                 320 


Lys Arg Ile Glu Lys Leu Gln Glu Lys Thr Val Asn Arg Thr Asp Gly 
                325                 330                 335     


Asp Ile Lys Asn Thr Tyr Val Asn Thr Tyr Val Leu Leu Asp Lys His 
            340                 345                 350         


Glu Lys Phe Lys Lys Tyr Asn Arg Asn Lys Lys Asp Thr Ile Ile Lys 
        355                 360                 365             


Ser Phe Ile Lys Asn Ile Lys Asp Asn Thr Met Lys Gln Lys Ile Asn 
    370                 375                 380                 


Gln Ile Leu Arg Lys Phe Lys Ile Glu Glu Leu Ile Glu Lys Leu Arg 
385                 390                 395                 400 


Ile Lys Asn Lys Asn Phe Asp Thr Glu Ile Phe Lys Ile Phe Lys Asp 
                405                 410                 415     


His Tyr Gln Glu Met Phe Ser Ser Glu Lys Phe Glu Glu Lys Ser Asp 
            420                 425                 430         


Glu Glu Lys Glu Leu Tyr Lys Ile Ile Tyr Arg Tyr Leu Lys Gly Arg 
        435                 440                 445             


Ile Glu Lys Ile Leu Ile Asn Glu Gln Lys Val Arg Leu Lys Lys Met 
    450                 455                 460                 


Glu Lys Ile Glu Ile Glu Lys Ile Leu Asn Glu Ser Ile Leu Ser Glu 
465                 470                 475                 480 


Lys Val Leu Lys Arg Val Lys Gln Tyr Thr Leu Glu Tyr Val Met Tyr 
                485                 490                 495     


Leu Gly Lys Leu Ile His Asn Asp Val Asn Met Thr Thr Val Asn Thr 
            500                 505                 510         


Asp Asp Phe Thr Lys Leu His Ala Glu Glu Glu Leu Asp Leu Glu Leu 
        515                 520                 525             


Ile Thr Phe Phe Ala Ser Thr Asn Met Glu Leu Asn Lys Ile Phe Asn 
    530                 535                 540                 


Gly Lys Glu Lys Ile Thr Asp Phe Phe Gly Phe Asn Leu Asn Gly Gln 
545                 550                 555                 560 


Lys Ile Thr Leu Lys Glu Lys Val Pro Asp Phe Lys Leu Asn Ile Leu 
                565                 570                 575     


Lys Lys Leu Asn Phe Ile Asn Asn Glu Asn Asn Ile Asp Glu Lys Leu 
            580                 585                 590         


Ser His Phe Tyr Ser Phe Gln Lys Glu Gly Tyr Leu Leu Arg Asn Arg 
        595                 600                 605             


Ile Leu His Asn Ser Tyr Gly Asn Ile Gln Glu Thr Lys Asn Leu Glu 
    610                 615                 620                 


Gly Glu Tyr Glu Asn Val Glu Asn Leu Ile Lys Glu Leu Lys Val Ser 
625                 630                 635                 640 


Asp Glu Glu Ile Ser Lys Ser Leu Asn Leu Asp Ile Ile Phe Glu Gly 
                645                 650                 655     


Lys Val Asp Ile Ile Asn Lys Ile Asn Ser Leu Glu Ile Gly Glu Tyr 
            660                 665                 670         


Lys Asp Lys Lys Tyr Leu Pro Ser Phe Ser Lys Ile Ile Pro Glu Ile 
        675                 680                 685             


Ile Arg Lys Phe Arg Glu Ile Asn Lys Asp Lys Leu Phe Asp Glu Glu 
    690                 695                 700                 


Ser Glu Lys Ile Ile Leu Asn Val Val Lys Tyr Val Asn Lys Ile Leu 
705                 710                 715                 720 


Tyr Glu Lys Ile Thr Ser Asn Glu Glu Asn Lys Phe Ile Lys Thr Leu 
                725                 730                 735     


Pro Asp Lys Leu Val Lys Lys Asn Asn Ile Lys Lys Glu Asn Lys Asn 
            740                 745                 750         


Leu Leu Ser Ile Glu Glu Tyr Tyr Lys Asn Ala Gln Val Ser Ser Ser 
        755                 760                 765             


Lys Gly Asp Lys Lys Ala Ile Lys Lys Tyr Gln Asn Lys Val Ile Asn 
    770                 775                 780                 


Ala Tyr Leu Glu Tyr Leu Glu Asn Thr Phe Glu Lys Val Ile Asp Phe 
785                 790                 795                 800 


Ser Asn Phe Asn Leu Asn Tyr Asn Glu Ile Lys Thr Lys Ile Glu Glu 
                805                 810                 815     


Arg Lys Asn Ser Lys Asn Lys Ile Val Ile Lys Ser Ile Pro Ile Asn 
            820                 825                 830         


Ile Asn Ile Thr Asn Asp Thr Glu Tyr Ile Ile Ser Ile Phe Ala Leu 
        835                 840                 845             


Leu Asn Asn Asn Thr Tyr Leu Asn Lys Ile Arg Asn Arg Phe Phe Ala 
    850                 855                 860                 


Thr Ser Val Trp Leu Asn Thr Gln Glu Tyr Glu Asn Leu Ile Asp Ile 
865                 870                 875                 880 


Leu Asp Lys Val Leu Ser Ile Asn Leu Leu Arg Glu Asn Asn Ile Ile 
                885                 890                 895     


Asp Ile Leu Asp Leu Lys Asn Thr Ile Ile Glu Ala Lys Ile Thr Glu 
            900                 905                 910         


Asn Asn Glu Glu Tyr Ile Arg Asn Tyr Ile Phe Glu Asn Asn Lys Glu 
        915                 920                 925             


Glu Leu Lys Lys Arg Leu Phe Cys Glu Glu Leu Asp Asn Lys Glu Asp 
    930                 935                 940                 


Val Leu Lys Ile Phe Glu Asp Lys Asn Phe Lys Phe Lys Asn Phe Ile 
945                 950                 955                 960 


Lys Lys Asn Glu Ser Gly Asn Phe Lys Ile Asn Phe Ala Ile Leu Ser 
                965                 970                 975     


Asn Leu Glu Cys His Phe Glu Leu Asp Thr Lys Lys Val Ile Gly Lys 
            980                 985                 990         


Asn Ser Lys Lys Leu Glu Ser Phe  Ile Gln Asn Thr Ile  Asp Glu Tyr 
        995                 1000                 1005             


Lys Ser  Asn Ile Arg Thr Leu  Phe Ser Ser Glu Phe  Leu Glu Lys 
    1010                 1015                 1020             


Tyr Lys  Lys Glu Ile Asp Asn  Leu Ile Gly Asp Ile  Glu Ser Glu 
    1025                 1030                 1035             


Asn Glu  Ser Lys Phe Glu Lys  Ile Tyr Tyr Pro Glu  Glu His Lys 
    1040                 1045                 1050             


Asn Glu  Leu Tyr Ile Tyr Lys  Lys Asn Leu Phe Leu  Asn Ile Gly 
    1055                 1060                 1065             


Asn Pro  Asn Phe Asp Lys Ile  Tyr Glu Ile Ile Ser  Lys Asp Ile 
    1070                 1075                 1080             


Lys Asn  Thr Asn Thr Glu Ile  Leu Phe Asp Asn Asp  Ile Arg Lys 
    1085                 1090                 1095             


Asn Lys  Ile Ser Glu Ile Asp  Ala Ile Leu Lys Asn  Leu Asn Asp 
    1100                 1105                 1110             


Lys Leu  Asn Gly Tyr Ser Asn  Asp Tyr Lys Ala Lys  Tyr Val Asn 
    1115                 1120                 1125             


Lys Leu  Lys Glu Asn Asp Asp  Phe Phe Ala Lys Asn  Ile Gln Asn 
    1130                 1135                 1140             


Glu Asn  Tyr Ser Ser Phe Gly  Glu Phe Glu Lys Asp  Tyr Asn Lys 
    1145                 1150                 1155             


Val Ser  Glu Tyr Lys Lys Ile  Arg Asp Leu Val Glu  Phe Asn Tyr 
    1160                 1165                 1170             


Leu Asn  Lys Ile Glu Ser Tyr  Leu Ile Asp Ile Asn  Trp Lys Leu 
    1175                 1180                 1185             


Ala Ile  Gln Met Ala Arg Phe  Glu Arg Asp Met His  Tyr Ile Val 
    1190                 1195                 1200             


Asn Gly  Leu Arg Glu Leu Gly  Ile Ile Lys Leu Ser  Gly Tyr Asn 
    1205                 1210                 1215             


Thr Gly  Ile Ser Arg Ala Tyr  Pro Lys Arg Asn Gly  Ser Asp Gly 
    1220                 1225                 1230             


Phe Tyr  Thr Thr Thr Ala Tyr  Tyr Lys Phe Phe Asp  Glu Glu Ser 
    1235                 1240                 1245             


Tyr Lys  Lys Phe Glu Lys Ile  Cys Tyr Gly Phe Gly  Ile Asp Leu 
    1250                 1255                 1260             


Ser Glu  Asn Ser Glu Ile Asn  Lys Pro Glu Asn Glu  Ser Ile Arg 
    1265                 1270                 1275             


Asn Tyr  Ile Ser His Phe Tyr  Ile Val Arg Asn Pro  Phe Val Asp 
    1280                 1285                 1290             


Tyr Ser  Ile Thr Glu Gln Ile  Asp Arg Val Ser Asn  Leu Leu Ser 
    1295                 1300                 1305             


Tyr Ser  Thr Arg Tyr Asn Asn  Ser Thr Tyr Ala Ser  Val Phe Glu 
    1310                 1315                 1320             


Val Phe  Lys Lys Asp Val Asp  Leu Asp Tyr Asp Lys  Leu Lys Thr 
    1325                 1330                 1335             


Lys Phe  Lys Leu Phe Asp Asp  Glu Lys Asn Asn Asp  Ile Lys Ile 
    1340                 1345                 1350             


Leu Lys  Ile Lys Asp Leu Ile  Glu Ser Lys Lys Val  Ser Val Leu 
    1355                 1360                 1365             


Glu Leu  Lys Ser Tyr Asn Ser  Asp Tyr Ile Lys Asn  Leu Ile Ile 
    1370                 1375                 1380             


Glu Leu  Leu Thr Lys Val Glu  Asn Lys Asp Glu Leu  Ser Ser 
    1385                 1390                 1395         


<210>  1011
<211>  1545
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1011

Met Lys Val Ala Lys Val Glu His Ala Arg Thr Ala Val Gly Glu Arg 
1               5                   10                  15      


Lys Glu Ile Gln Lys Asn Ser Val Gly Gly Phe Ile Tyr Asn Asp Pro 
            20                  25                  30          


Ala Gln Pro Lys Lys Lys Asn Pro Ser Glu Met Glu Val Ile Gln Asn 
        35                  40                  45              


Leu Asp Thr Arg Phe Ser Glu Leu Asn Asn Arg Ala Gln Asn Leu Lys 
    50                  55                  60                  


Phe Asn Val Phe Asn Glu Ile Gln Pro Gly Ser Ala Pro Ala Lys Pro 
65                  70                  75                  80  


Lys Lys Tyr Asp Ala Tyr Lys Ala Asp Pro Glu Phe Ser Ser Val Pro 
                85                  90                  95      


Asp Met Asp Ala Ile Glu Lys Gln Lys Ile Arg Glu Ser Cys Glu Ser 
            100                 105                 110         


Tyr Asp Val Arg Lys Gln Asn Phe Asp Arg Arg Leu Lys Tyr Lys Lys 
        115                 120                 125             


Ile Ala Glu Val Leu Asn Ile Asn Leu Ser Lys Leu Ile Phe Thr Tyr 
    130                 135                 140                 


Lys Asp Thr Gly Arg Thr Ser Lys Arg Gly Asp Lys Ile Tyr Val Val 
145                 150                 155                 160 


Ser Gly Val Gln Thr Pro Glu Lys Leu Arg Asp Leu Ala Ser Ser Tyr 
                165                 170                 175     


Lys Trp Gln Asp Glu Val Pro Glu Glu Glu Asp Ile Arg Gly Ile Cys 
            180                 185                 190         


Glu Gly Tyr Val Arg Ser Ser Leu Arg Thr Cys Val Gln Lys Val Glu 
        195                 200                 205             


Gly Ala Ser Lys Ala Glu Thr Ile Asp Leu Arg Lys Val Ile Ala Lys 
    210                 215                 220                 


Met Leu Leu Ala Met Ser Gly Gln Leu Ser Ala Glu Glu Leu Ser Leu 
225                 230                 235                 240 


Gln Glu Ile Thr Ala Phe Thr Glu Thr Leu His Glu Ala Tyr Tyr Arg 
                245                 250                 255     


Thr Asn Gln Gln Thr Leu Val Thr Arg Ser Ile Tyr His Gln Asn Met 
            260                 265                 270         


Val Val Gln Pro Asp Glu Gln Gly Val Val Ser Leu Ser Lys Val Glu 
        275                 280                 285             


Gln Asp Lys Lys Gln Lys Lys Leu Glu Ser Thr Gly Arg Ser Arg Lys 
    290                 295                 300                 


Asn Tyr Glu Lys Ala Gly Glu Met Lys Thr Leu Ser Asp Tyr Ala Val 
305                 310                 315                 320 


Leu Ser Lys Asp Glu Arg Met Val Ile Leu Arg Lys Leu Arg Arg Ile 
                325                 330                 335     


Leu Asp Ile Tyr Phe Ser His Ser Glu Lys Glu Asp Pro Lys Asn Ala 
            340                 345                 350         


Pro Leu Ala Pro Ser Ile Pro Ile Asn Asp Thr Phe Asp Val Trp Ala 
        355                 360                 365             


Asp His Glu Glu Lys Lys Gln Thr Glu Gly Met Phe Val Ser Ile Pro 
    370                 375                 380                 


Glu Val Ile Ser Ser Ala Ala Lys Glu Asn Arg Thr Leu Asp Ser Leu 
385                 390                 395                 400 


Val Ser Lys Asn Ala Phe Asp Met Leu Asn Thr Ala Ile Arg Asn His 
                405                 410                 415     


Asn Met Ala Cys Tyr Arg Tyr Thr Ile Arg Met Ile Lys Glu Asn Ala 
            420                 425                 430         


Ala Leu Phe Phe Pro Asp Asp Ala Gln Asn Thr Phe Trp Val His His 
        435                 440                 445             


Ile Glu Ser Glu Val Glu Arg Ile Leu Thr Arg Leu Thr Thr Gly Asp 
    450                 455                 460                 


Leu Phe Lys Leu Gln Thr Gly Tyr Leu Ser Glu Lys Val Trp Lys Gly 
465                 470                 475                 480 


Met Ile Asn Glu Leu Ser Ile Lys Tyr Ile Ala Ile Gly Lys Ala Val 
                485                 490                 495     


Tyr Asn Phe Ala Met Thr Gly Leu Thr Glu Asp Gly Asp Ile Asp Leu 
            500                 505                 510         


Thr Lys Met Gln Asp Val Lys Gly Ile Thr Ser Tyr Asp Tyr Glu Met 
        515                 520                 525             


Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Thr Ala Val Asn Ile Ser 
    530                 535                 540                 


Tyr Ala Ala Asn Asn Leu Ala Arg Ala Thr Val Asn Val Pro Glu Gly 
545                 550                 555                 560 


Asp Glu Asp Phe Leu Leu Trp Lys Ile His Glu Lys Glu Leu Glu Lys 
                565                 570                 575     


Asp His Phe Tyr Asn Arg Met Lys Ser Asp Asp Gly Arg Gly Thr Ile 
            580                 585                 590         


Thr Ala Ile Phe Gln Phe Phe Gly Gly Ile Ser Ser Trp Pro Glu Gly 
        595                 600                 605             


Thr Val Glu Lys Ile Met Gln Ala Tyr Ser Ala Phe Ser Gly Arg Glu 
    610                 615                 620                 


Gly Val His Phe Leu Asn Asp Leu Lys Glu Ala Ile Phe Leu Leu Arg 
625                 630                 635                 640 


Asn Lys Thr Phe His Phe Asn Ser Lys Arg Lys Lys Asp Tyr Pro Trp 
                645                 650                 655     


Asn Gln Glu Leu Ile Cys Ser Leu Phe Glu Gln Asp Leu Lys Ser Ala 
            660                 665                 670         


Asn Asp Arg Leu Lys Asp Lys Phe Tyr Ser Asn Asn Leu Pro Asp Tyr 
        675                 680                 685             


Tyr Ser Glu Glu Asp Leu Arg Arg Val Met Asp Phe Leu Tyr Ala Lys 
    690                 695                 700                 


Pro Ala Asp Arg Ala Thr Gln Val Pro Ser Phe Asn Arg Val Phe Ala 
705                 710                 715                 720 


Gly Gln Asp Tyr Gln Asp Phe Phe Ala Ala Tyr Ile Asn Gln Lys Asn 
                725                 730                 735     


His Phe Arg Gly Ala Asp Gln Ala Asp Ile Leu Ser Lys Trp Lys Ser 
            740                 745                 750         


Ala Val Phe Tyr Leu Cys Lys Glu Ile Tyr Tyr Asn Gly Phe Leu Gln 
        755                 760                 765             


Glu Gly Ser Ala Arg Lys Leu Phe Phe Thr Ala Ile Ser Asn Asn Arg 
    770                 775                 780                 


Lys Ala Leu Glu Gln Lys Asn Asn Glu Lys Lys Leu Ser Lys Asp Glu 
785                 790                 795                 800 


Arg Thr Asn Leu Gln Ala Val Lys Asp Phe Ser Lys Arg Cys Asp Thr 
                805                 810                 815     


Leu Lys Asp Asn Ser Leu Ala Glu Ile Cys Gln Ala Ile Met Thr Glu 
            820                 825                 830         


Tyr Asn Leu Gln Asn Ser Gly His Arg Lys Val Gln Ser Ser Asp Asp 
        835                 840                 845             


Glu Lys Arg Asp Ala Lys Ile Phe Gln His Phe Glu Thr Leu Leu Lys 
    850                 855                 860                 


Lys Met Leu Arg Asp Ala Phe Cys Leu Tyr Leu Gln Gln Asn Asp Arg 
865                 870                 875                 880 


Tyr Thr Phe Leu Val Lys Gln Thr Asp Ala Leu Asn Glu Lys Val Asp 
                885                 890                 895     


Gln Lys Asp Phe Leu Lys Gly Trp Gln Ser Gln Gln Tyr Ala Asp Leu 
            900                 905                 910         


Met Gln Thr Val Arg Glu Asn Pro Glu Leu Gln Ala Trp Tyr Val Cys 
        915                 920                 925             


Gly Arg Phe Leu Asn Gly Lys Thr Leu Asn Leu Leu Ser Gly Asp Leu 
    930                 935                 940                 


Arg Gln Tyr Ile Gln Phe Glu Ser Asp Val Lys Arg Arg Ala Ala Ala 
945                 950                 955                 960 


Thr Lys Asn Ala Pro Lys Asn Leu Glu His Phe Asp Ser Leu Lys Asn 
                965                 970                 975     


Asp Cys Arg Gln Ala Val Arg Val Leu Asp Val Cys Ile Gln Leu Ser 
            980                 985                 990         


Ser Val Phe Ser Lys Glu Ile Thr  Asp Tyr Phe Ser Ser  Asn Glu Glu 
        995                 1000                 1005             


Tyr Ala  Gln Tyr Leu Ser Lys  Tyr Ile Glu Tyr Ile  Asp Pro Ser 
    1010                 1015                 1020             


Ser Ser  Leu Ser Ala Phe Asp  Gln Leu Arg Asp Phe  Ser Ala Gly 
    1025                 1030                 1035             


Leu Glu  Asp Glu Val Lys Asn  Leu Tyr Met Asp Glu  Lys Asn Pro 
    1040                 1045                 1050             


Ile Pro  Asn Arg Asn Leu Ile  Met Ser Lys Leu Tyr  Gly Pro Asp 
    1055                 1060                 1065             


Arg Ile  Leu Ala Glu Ile Val  Asn Val Thr Thr Asn  Asp Ile Ala 
    1070                 1075                 1080             


Ala Tyr  Arg Ala Arg Lys Val  Glu Val Glu Glu Asn  Arg Lys Lys 
    1085                 1090                 1095             


Glu Ala  Ala Glu Thr Gly Gln  Asn Asn Val Asp Leu  Leu Ser Val 
    1100                 1105                 1110             


Ala Glu  Arg Asn Thr Phe Thr  Glu Tyr Gln Tyr Leu  Lys Asn Lys 
    1115                 1120                 1125             


Val Glu  Leu Arg Asn Val Val  Asp Tyr Gly Glu Leu  Ile Asn Glu 
    1130                 1135                 1140             


Leu His  Gly Gln Leu Val Asn  Trp Ser Phe Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Leu Leu  Tyr Phe Gln Leu Gly  Phe His Tyr Val Cys  Leu His Asn 
    1160                 1165                 1170             


Asp Ser  Ala Lys Pro Asp Ile  Tyr Arg Cys Ile Thr  Arg Lys Asn 
    1175                 1180                 1185             


Asn Ser  Gln Val Asn Gly Ala  Ile Leu Tyr Gln Leu  Ala Ala Met 
    1190                 1195                 1200             


Tyr Ile  Gln Gly Ile Pro Met  Tyr Ser Pro Ala Ala  Asn Lys Thr 
    1205                 1210                 1215             


Asp Ala  Glu Pro Thr Asp Thr  Gly Met Lys Glu Arg  Asn Gly Asn 
    1220                 1225                 1230             


Met Ser  Pro Gly Gly Lys Tyr  Arg Phe Phe Cys Asn  Tyr Ser Gly 
    1235                 1240                 1245             


Ala Met  Thr Gly Ala Ile Ala  Arg Asp Lys Asp Gly  Val Leu Gln 
    1250                 1255                 1260             


Tyr Phe  Asp Glu Ser Ile Tyr  Glu Ala Gly Leu Glu  Leu Phe Glu 
    1265                 1270                 1275             


Asn Val  Lys Glu His Glu Asn  Ile Ile Asn Leu Arg  Asp Ala Ile 
    1280                 1285                 1290             


Asp His  Phe Lys Tyr Tyr Ser  Gly Lys Thr Gly Ser  Leu Leu Asp 
    1295                 1300                 1305             


Leu Tyr  Ser Glu Val Phe Asp  Arg Phe Phe Thr Tyr  Asp Met Arg 
    1310                 1315                 1320             


Tyr Lys  Lys Asn Val Pro Asn  Leu Leu Gly Asn Ile  Leu Gln Arg 
    1325                 1330                 1335             


His Phe  Val Thr Met Arg Pro  Tyr Phe Gly Ser Ala  Lys Lys Gln 
    1340                 1345                 1350             


Val Gly  Lys Ser Glu Glu Lys  Ala Arg Ala Ser Ile  Asp Ile Ala 
    1355                 1360                 1365             


Asn Phe  Gly Leu Lys Ser Asp  Arg Phe Thr Tyr Lys  Val Lys Asp 
    1370                 1375                 1380             


Asn Asp  Gly Asp Ala Arg Lys  Trp Glu Glu Asp Ala  Arg Asn Thr 
    1385                 1390                 1395             


Asp Tyr  Leu Glu Thr Ile Gly  Arg Ile Leu Tyr Tyr  Pro Val Thr 
    1400                 1405                 1410             


Leu Pro  Asp Asp Lys Ile Ala  Glu Pro Gly Lys Gly  Lys Phe Val 
    1415                 1420                 1425             


Asp Asp  Lys Gly Lys Lys Cys  Ala Gly Arg Arg Thr  Lys Ala Asn 
    1430                 1435                 1440             


Asn Lys  Pro Ile Asn Ala Ala  Gly Lys Glu Ser Val  Glu Arg Lys 
    1445                 1450                 1455             


Gln Arg  Asn Ser Glu Asn Ala  Glu Arg Lys Leu Leu  Thr Asp Tyr 
    1460                 1465                 1470             


Lys Lys  Gly Gln Lys Val Thr  Gly Val Val Thr Asn  Ile Thr Ser 
    1475                 1480                 1485             


Phe Gly  Ala Phe Val Asp Phe  Gly Ala Glu Lys Lys  Gly Leu Val 
    1490                 1495                 1500             


His Ile  Ser Lys Met Ser His  Asp Phe Val Asn Asp  Pro His Asp 
    1505                 1510                 1515             


Ile Val  Lys Glu Gly Glu Met  Ile Thr Val Lys Ile  Ile His Ile 
    1520                 1525                 1530             


Asp Leu  Asp Asn Gly Lys Ile  Ser Leu Ser Met Ile  
    1535                 1540                 1545 


<210>  1012
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1012

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Asn Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Tyr Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Ser Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Val Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Val 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Lys Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Lys Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Leu Lys Glu Leu Lys Glu Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn Tyr Thr Met Gln Gln Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Lys Lys Asp Glu Lys Phe Asn Asp Glu Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Met Asn Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Lys Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Glu 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Glu Lys Leu Thr Thr  Asn Arg Asn Ser Lys  Glu Leu Cys 
    1130                 1135                 1140             


Lys Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Glu  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  1013
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1013

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  1014
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1014

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Thr Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Tyr Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asn Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Val Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Val 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Lys Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Met 
    690                 695                 700                 


Tyr Ile Gly Asn Asp Glu Gln Ile Asn Thr Ser Leu Ala Gly Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Lys Ile Leu Lys Tyr Thr Glu Ser Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Lys Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Leu Lys Glu Leu Lys Glu Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn Tyr Thr Met Gln Gln Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Lys Lys Asp Glu Lys Phe Asn Asp Glu Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Ile Met Lys Ser  Val Val Asn Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Lys Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Lys Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Glu  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  1015
<211>  1250
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1015

Met Lys Ile Val Lys Pro Tyr Gly Leu Ser Ala Thr Asp Lys Lys Gly 
1               5                   10                  15      


Glu Arg Tyr Leu Arg Ala Arg Leu Leu Lys Arg Asn Glu Ala Gly Glu 
            20                  25                  30          


Thr Gln Ile Pro Glu Thr Ala Phe Lys Glu His Glu Phe Gly Glu Phe 
        35                  40                  45              


Asn Gln Ser Asp Pro Arg Ile Leu Ile Gly Gln Trp Ile Ser Ile Ile 
    50                  55                  60                  


Asp Lys Ile Ile Arg Lys Pro Asn Gln Lys Asp Phe Gln Pro Lys Gly 
65                  70                  75                  80  


Met Cys Asp Arg Thr Asn Ser Pro Thr Asn Asn Asp Val Arg Arg Arg 
                85                  90                  95      


Ala Gln Val Lys Phe Arg Thr Glu Leu Gly Arg Ala Cys Trp Asn Leu 
            100                 105                 110         


Leu Glu Glu Arg Lys Leu Leu Asp Arg Lys Ala Leu Asp Asp Phe Ala 
        115                 120                 125             


Pro Ile Trp Ala Gln Lys Leu His Pro Ala Gly Asp Val Pro Glu Glu 
    130                 135                 140                 


Phe Gln Ser Asp Arg Gln Lys Lys Asn Glu Arg Gly Lys Lys Ile Trp 
145                 150                 155                 160 


Glu Asp Asn Lys Pro Val Trp Asp Asp Glu Tyr Ile Leu Asn Ile Thr 
                165                 170                 175     


Gly Leu Trp Tyr Val Arg Phe Met Gly Glu Asp Thr Lys Leu Asp Asn 
            180                 185                 190         


Glu Glu Gln Leu Asp Gln Leu Glu Phe Asp Asn Ile Ala Ala Asp Ile 
        195                 200                 205             


Phe Lys His Leu His Glu Lys Glu Phe Lys Lys His Asp Gly Glu Lys 
    210                 215                 220                 


Ser Ile Gly Leu Ile Glu Ala Arg Ala Ile Ser Val Ala Asn Ser Ser 
225                 230                 235                 240 


Pro Lys Lys His Met Glu Lys Met Trp Val Glu Gly Glu Gly Thr Lys 
                245                 250                 255     


Leu Leu Glu Ser Leu Thr Gln Glu Lys Ile Met Leu Pro Trp Thr Asp 
            260                 265                 270         


Val Asp Glu Lys Ser Phe Ile Asn Gly Lys Arg Val His Ser Leu Ala 
        275                 280                 285             


Glu Gln Ile Ser Ala Thr Asn Ala His Leu Glu Asp Gln Lys Gln Arg 
    290                 295                 300                 


Leu His Tyr Asp Ile Val Gly Gly Tyr Ile Phe Glu His Tyr Arg Lys 
305                 310                 315                 320 


Gln Phe Ile Asp Lys Asp Gly Ala Val Pro Lys Arg Val Asp Ile Ala 
                325                 330                 335     


Lys Glu Arg Phe Gly Leu Leu Ala Leu Tyr Asp Glu Val Arg Ser Leu 
            340                 345                 350         


Tyr Lys Gly Leu Ile Lys Asn Ser Asn Lys Lys Ser Leu Lys Arg Thr 
        355                 360                 365             


Leu Pro Ala Asn Asp Lys Glu Leu Phe Thr Leu Leu Arg Gln Arg His 
    370                 375                 380                 


Ala Asn Lys Ile Thr Asn Asn Leu Ile Arg Leu Gly Lys Ile Leu His 
385                 390                 395                 400 


Tyr Glu Gly Thr Val Gly Asp Gly Asp Gly Phe Gly Leu Ser Leu Asn 
                405                 410                 415     


Lys Ser Gly Asn Ile Lys Gln Gly Gly Gln Asp Ile Phe Ala Leu Asn 
            420                 425                 430         


Leu Lys Asp Ile Ala Asn Ser Ala Tyr Trp Lys Ser Asp Gly Gln Ala 
        435                 440                 445             


Asp Ile Lys Arg Thr Glu Ala Phe Val Arg Ile Trp Arg Asn Thr Ile 
    450                 455                 460                 


Ser Gln Ala Gln Arg Thr Ala Gln Thr Leu Ala Asp Pro Asp Gly Lys 
465                 470                 475                 480 


Phe Ser Lys Ala Leu Gly Arg Pro Leu Asp Val Leu Glu Asp Lys Val 
                485                 490                 495     


Ser Pro Met Leu Ser Thr Asp Asp Lys Val Met Gly Arg Ala Asn Asn 
            500                 505                 510         


Asn Ala Lys Leu Leu Phe Gly Val Gln Ala Lys Leu Phe Glu Asp Val 
        515                 520                 525             


Asp Pro Ser Asp Phe Ile Tyr Gly Thr Leu Arg Leu Leu Ala Asn Ile 
    530                 535                 540                 


Arg Asn Lys Ala Phe His Phe Asn Gly Arg Arg Ala Phe Val Gln Lys 
545                 550                 555                 560 


Met Ile Ser Gly Phe Asp Glu Asp Asn Ile Lys Asn Ile Val Thr His 
                565                 570                 575     


Glu Lys Thr Val Asp Leu Asp Gly Phe Trp Thr Gln Val Lys Ala Leu 
            580                 585                 590         


Leu Ala Ser Asp Gln Met Glu Arg Phe Lys Arg Gln Ile Ser Val Leu 
        595                 600                 605             


Glu Gly Ala Gln Phe Asn Cys Phe Ala Thr Thr Asn Gln Ile Asn Asn 
    610                 615                 620                 


Tyr Leu Lys Leu Leu Ser His Asn Glu Ser Asp Val Ser Leu Pro Arg 
625                 630                 635                 640 


Phe Asn Lys Leu Leu Thr Arg Ile Asp Asn Thr Thr Gln Lys Ile Ser 
                645                 650                 655     


Arg Thr Asn Asn Trp Phe Phe Pro Glu Pro Ala Ser His Val Asp Leu 
            660                 665                 670         


Asn Ala Phe Pro Ala Met Leu Thr Lys Phe Val Gly Leu Lys Ile Leu 
        675                 680                 685             


Tyr Glu Gly Pro Phe Arg Ala Trp Val His Lys Ile Lys Pro Glu Lys 
    690                 695                 700                 


Leu Ala Glu Tyr Arg Asn Ala Ala Ala Asp Leu Gly Ser Lys Ala Ala 
705                 710                 715                 720 


Lys Lys Ile Asn Ser Gln Ser Lys Tyr Pro Glu Leu Ile Arg Ala Lys 
                725                 730                 735     


Thr Glu Asp Leu Pro Leu Ile Ser Lys Ile Asp Thr Ile Ser Ser Tyr 
            740                 745                 750         


Met Asp Thr Leu Gln Ala Phe Gln Ala Ser Glu Gln Arg Leu Gln Lys 
        755                 760                 765             


Gly Tyr Glu Ser Asn Ser Ser Ala Ala Lys Glu Gln Ala Glu Trp Ile 
    770                 775                 780                 


Glu Asn Phe Arg Lys Asp Ile Leu Ala Arg Ala Phe Arg Asp Tyr Leu 
785                 790                 795                 800 


Asn Glu His Phe Ser Gln Leu Lys Trp Leu Leu Glu Leu Lys Lys Ala 
                805                 810                 815     


Asp Ala Pro Arg Glu Pro Gln Ala Met Pro Lys Ala Gly Ser Ala Thr 
            820                 825                 830         


Asp Gly Glu Thr Leu Ser Glu Ser Trp His Ala Ala Leu Tyr Tyr Ile 
        835                 840                 845             


Leu His Leu Val Pro Ala Tyr Glu Val Ser Arg Leu Leu His Gln Ile 
    850                 855                 860                 


Arg Lys Trp Gly Ile Leu Glu Lys Lys Ser Gly Ala Thr Asp Glu Pro 
865                 870                 875                 880 


Asp Thr Asp Val Glu Asn Leu Arg Arg Leu Leu Ile Leu Tyr Ile Glu 
                885                 890                 895     


Met Ser Glu Asp Lys His Thr Gly Glu Gly Ile Ala Leu Glu Gly Met 
            900                 905                 910         


Asp Lys Phe Tyr Asp Met Phe Lys Asp Lys Gln Thr Gly Phe Asp Lys 
        915                 920                 925             


Val Phe Lys Thr Glu Gly Ser Thr Glu Asp Val Leu Ala Ser Thr Arg 
    930                 935                 940                 


Arg Gly Leu Arg Glu Ile Leu Arg Tyr Gly Asn Lys Asn Val Leu Thr 
945                 950                 955                 960 


Val Ala Ile Gly Glu Val Lys Val Thr Asp Asn Asp Ile Thr Ala Tyr 
                965                 970                 975     


Arg Asp Gln Gln Ala Gly Ile Glu Arg Ala Gln Leu Lys Arg Lys Lys 
            980                 985                 990         


Ile His Ser Glu Leu Ile Lys Arg  Ala Gly Asp Lys Asn  Gln Gln Phe 
        995                 1000                 1005             


Val Glu  Tyr Val Thr Ala Leu  Lys Ser Ile Ile Ser  Tyr Arg Glu 
    1010                 1015                 1020             


Leu Ser  His Arg Val Asn Leu  Thr Asn Phe Val Lys  Leu His Lys 
    1025                 1030                 1035             


Ile Met  Leu Gln Val Val Ala  Arg Leu Ile Asp Tyr  Ala Gly Val 
    1040                 1045                 1050             


Trp Glu  Arg Asp Gly Tyr Phe  Ile Ala Thr Ala Leu  Met Lys Ile 
    1055                 1060                 1065             


His Gly  Lys Lys Pro Glu Asp  Val Leu Gly Asp Gly  Ala Pro Trp 
    1070                 1075                 1080             


Phe Arg  Ser Ala Gly Lys Leu  Pro Arg Thr Glu Ser  Met Asp Ile 
    1085                 1090                 1095             


Thr Phe  Leu Gly Gln Leu Ser  Arg Phe Tyr Thr Pro  Gln Leu Thr 
    1100                 1105                 1110             


Gln Ile  Arg Lys Asp Leu His  His Phe Asn Leu Val  Ala Gly Asp 
    1115                 1120                 1125             


Asp Val  Asp Leu Thr Gly Ala  Val Asn Asn Val Arg  Arg Leu Met 
    1130                 1135                 1140             


Ala Tyr  Asp Arg Lys Met Lys  Asn Ala Val Ser Lys  Ser Ile Lys 
    1145                 1150                 1155             


Glu Met  Met Asp Glu Glu Gly  Leu Phe Leu Cys Trp  Lys Met Asp 
    1160                 1165                 1170             


Ala Ser  His Asn Leu Ala Leu  Asp Pro Glu Cys Ile  Arg Asn Gly 
    1175                 1180                 1185             


Gln Lys  Val Pro Ala Ile Glu  Ser Arg Val Ile Lys  His Leu Gln 
    1190                 1195                 1200             


Lys Gly  Trp Arg Pro Lys Arg  Glu Ser Tyr Ala Ala  Arg Gln Lys 
    1205                 1210                 1215             


Asp Asn  Gln Ala Leu Ser Glu  Asn Phe His Asp Asp  Asn Phe Val 
    1220                 1225                 1230             


Arg Ala  Val Thr Cys Leu Phe  Ser Pro Asn Arg Ser  Thr Ser Ser 
    1235                 1240                 1245             


Pro Val  
    1250 


<210>  1016
<211>  1155
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1016

Met Lys Leu Thr Ala Thr Lys Asn Ser Ser Asn Ala Gln Phe Tyr Arg 
1               5                   10                  15      


Asp Lys Thr Lys Gly Gln Leu Ile Ser Thr Lys Val Asn Asn Thr Ser 
            20                  25                  30          


Lys Ile Ile Glu Lys Ser Asp Lys Thr Lys Asp Ile Ile Glu Asn Leu 
        35                  40                  45              


Asp His Lys Arg Ser Leu Lys Gly Arg Ile Leu Ile Asn Pro Asp Ser 
    50                  55                  60                  


Lys Gly Lys Ile Lys Leu Asn Thr Asn Glu Phe Lys Ile Lys Ile His 
65                  70                  75                  80  


Ile Glu Lys Ile Ile Asn Thr Leu Ile Tyr Asn Asn His Met Ser Glu 
                85                  90                  95      


Leu Tyr Asp Glu Lys Pro Thr Leu Ser Asp Asp Glu Lys Lys Asp Glu 
            100                 105                 110         


Asn Leu Lys Lys Ile Ile Asn Asn Thr Leu Ser Val Tyr Gly Lys Lys 
        115                 120                 125             


Ile Lys Tyr Asn Ser Asn Ser Lys Asn Leu Glu Glu Ile Leu Ile Cys 
    130                 135                 140                 


Tyr Phe Lys Asn Glu Asp Ile Thr Ser Glu Phe Glu Asn Ile Arg Asn 
145                 150                 155                 160 


Tyr Phe Gln Thr Val Ile Thr His Lys Lys Glu Lys Leu Val Lys Ser 
                165                 170                 175     


Ile Lys Asn Asn Lys Ile Pro Phe Asp Leu Asp Asn Asn Ser Leu Gln 
            180                 185                 190         


Pro Asn Ser Glu Lys Met Lys Trp Leu Phe Ser Phe Ile Lys Asn Gly 
        195                 200                 205             


Val Ile Thr Ala Glu Ile Lys Glu Asn Thr Phe Leu Lys Asp Ile Tyr 
    210                 215                 220                 


Lys Tyr Glu Asn Leu Glu Lys Val Leu Asn Glu Glu Leu Asn Asn Gln 
225                 230                 235                 240 


Ile Lys Asn Asn Lys Pro Val Met Thr Lys Lys Leu Tyr Gln Met Val 
                245                 250                 255     


Leu Asp Tyr Asn Gln Asp Ile Tyr Ile Asn His Ile Asn Gly Glu Asn 
            260                 265                 270         


Glu Gln Asp Ser Phe Tyr Leu Asn Glu Ile Arg Glu His Phe Arg Arg 
        275                 280                 285             


Tyr Leu Val Ile Ser Lys Lys Ser Asn Thr Lys Asn Gln Asn Gly Tyr 
    290                 295                 300                 


Asn Glu Lys Ile Lys Pro Glu Lys Ile Arg His His Ile Ala Tyr Glu 
305                 310                 315                 320 


Phe Val Thr Glu Asn Ile Gln Lys His Ile Ile Asn Gln Leu Val Ala 
                325                 330                 335     


Gly Leu Ile Gln Tyr Gly Lys Leu His His Tyr Phe Tyr Asp Lys Thr 
            340                 345                 350         


Thr Ser Ser Trp Gln Lys Glu Lys Leu Asn Ser Asp Gly Leu Ser Glu 
        355                 360                 365             


Ile Gln Val Glu Glu Ala Phe Lys Lys Gln Ile Leu Thr Ser Ile Ser 
    370                 375                 380                 


Ser Gly Ile Ala Lys Leu Asn Tyr Phe Tyr Asn His Gly Ser Gln Asn 
385                 390                 395                 400 


Glu Ser Lys Ile Asn Thr Asp Lys Asn Val Asp Val Leu Asp Ser Asp 
                405                 410                 415     


Lys Val Gln Leu Gln Leu Thr Ser Asp Thr Asp Asp Thr Glu Phe Lys 
            420                 425                 430         


Ile Ser Thr Cys Phe Pro Ile Asp Leu Ala Lys Asp Tyr Leu Asn Leu 
        435                 440                 445             


Glu Lys Phe Ile Asp Thr Ile Arg Gly Asn Ile Asp Lys Ile Arg Asn 
    450                 455                 460                 


Asn Thr Phe His Phe Lys Lys Asn Glu Leu Lys Asn Leu Phe Asn Asp 
465                 470                 475                 480 


Gly Ser Tyr Asn Asn Thr Asn Ile Thr Phe Ile Lys Glu Leu Phe Gln 
                485                 490                 495     


Arg Asp Leu Asn Ser Val Gln Glu Ser Phe Lys Glu Gln Ile Arg Ser 
            500                 505                 510         


Ser Gly Ile Thr Glu Tyr Cys Ser Phe Glu Leu Leu Lys Asn Ile Phe 
        515                 520                 525             


Gln Glu Asn Ser Phe Asp Phe Gln Leu Tyr Ser Pro Gln Tyr Pro Met 
    530                 535                 540                 


Ser Pro Ser Phe Lys Asn Ile Tyr Lys Arg Gly Cys Asn Leu Ser Asn 
545                 550                 555                 560 


Ala Thr Val Lys Asp Glu Lys Ile Lys Trp Ile Lys Pro Leu Asp Ala 
                565                 570                 575     


Asp Ala Glu Asn Asp Gly Gln Leu Ala Tyr Lys Asn Leu Leu Gln Leu 
            580                 585                 590         


Ile Tyr Tyr His Cys Phe Leu Pro Tyr Val Phe Lys Asn Glu Ser Tyr 
        595                 600                 605             


Leu Ile Lys Tyr Ile Lys Thr Thr Lys Asp Trp Asn Gln Gln Lys Ala 
    610                 615                 620                 


Lys Asn Asp Arg Gln Asn Arg His Gln Tyr Arg Tyr Glu Asn Met Pro 
625                 630                 635                 640 


Phe Tyr Asn Asn Asn Lys Phe Thr Ser Leu Asn Asp Tyr Phe Gln Asn 
                645                 650                 655     


Leu Gln Arg Leu Gln Ser Ile Tyr Glu Asn Asp Glu Asp Ala Lys His 
            660                 665                 670         


Glu Asn Tyr Tyr Leu Asp Phe Ile Gln Asp Ile Phe Leu Leu Ala Phe 
        675                 680                 685             


Asp Asn Tyr Leu Glu Asp Lys Leu Lys Asn Tyr Lys Tyr Lys Leu Ile 
    690                 695                 700                 


Phe Ser Glu Lys Leu Val Asp Ser Ser Leu Glu Ser Leu Glu Thr Leu 
705                 710                 715                 720 


Glu Lys Leu Phe Glu Lys Thr Asn Thr Ile Leu Lys Met Asn Val Asn 
                725                 730                 735     


Ser Ser Phe Glu Asn Asn Leu Asn Phe Tyr Ala Phe Leu Arg Val Leu 
            740                 745                 750         


Glu Lys Arg Glu Leu Asn Asn Leu Leu His Gln Ile Ile Lys Tyr Arg 
        755                 760                 765             


Thr Ser Lys Asn Glu Glu Ser Leu Arg Glu Ile Glu Glu Leu Ile Thr 
    770                 775                 780                 


Leu Val Gln Tyr Thr Ile Pro Leu Gln Thr Ala Asp Glu His Phe Gln 
785                 790                 795                 800 


Asn Glu Leu Lys Asn His Phe Lys Tyr Phe Phe Glu Asp Glu Asn Phe 
                805                 810                 815     


Asn Asn Asn Cys Glu Leu Tyr Tyr Gln Ser Asp Lys Lys Thr Pro Ile 
            820                 825                 830         


Ala His Arg Ser Met Ser Leu Met Gly Arg Ser Gly Ile Met Ala Leu 
        835                 840                 845             


Phe Lys Val Met Phe Ser Thr Asp Tyr Lys Ile Lys Lys Glu Asp Phe 
    850                 855                 860                 


Asp Asn Tyr Leu Lys Met Ile Asp Ser Ala Glu Leu Ile Asn Asp Glu 
865                 870                 875                 880 


Thr Pro Lys Ser Ile Gln Asp Lys Gln Lys Lys Val His Asp Leu His 
                885                 890                 895     


Arg Glu Leu Val Ser Lys Lys Ile Ile Asn Ile Lys Asn Lys Asp Glu 
            900                 905                 910         


Ile Asp Lys Leu Glu Glu Tyr Glu Lys Leu Val Lys Glu Ile Lys Glu 
        915                 920                 925             


Tyr Glu His Leu Arg His Lys Leu Thr Phe Glu Thr Leu Tyr Lys Val 
    930                 935                 940                 


Tyr Lys Ile Tyr Ile Asp Ile Ile Ser Arg Leu Ala Ser Phe Ala Glu 
945                 950                 955                 960 


Asp Trp Glu Arg Asp Met Tyr Phe Met Met Ile Ala Leu Lys Glu Leu 
                965                 970                 975     


Asn His Ile Asn Gln Asn Val Asp Ile Asp Glu Ile Phe Asn Tyr Asn 
            980                 985                 990         


Pro Val Asp Lys Lys Thr Val Ser  Gln Lys Phe Lys Glu  Asn Leu Gly 
        995                 1000                 1005             


Lys Thr  Ile Lys Asn Lys Asn  Leu Val Leu Phe Leu  Phe Trp Met 
    1010                 1015                 1020             


Asp Asn  Ser Lys Asn Asn Ser  Asn Asn Phe Leu Val  Arg Asn Ser 
    1025                 1030                 1035             


Ile Ala  His Leu Asn His Met  Asn Gln Tyr Lys Leu  Asn Asp Ala 
    1040                 1045                 1050             


His Ser  Gln Lys Asn Ile Ile  Glu Leu Ile Asn Arg  Ile Arg Ile 
    1055                 1060                 1065             


Leu Leu  Ala Tyr Asp Leu Lys  Arg Gln Asn Ser Val  Thr Lys Ser 
    1070                 1075                 1080             


Ile Ile  Glu Ile Leu Glu Lys  Gln His Asp Ile Lys  Ile Lys Phe 
    1085                 1090                 1095             


Thr Gly  Lys Lys Asp Asn Asn  Asn Tyr Asn Phe Glu  Leu Asn Ser 
    1100                 1105                 1110             


Val Glu  Ser Asp Asn Ile Ile  His Leu Lys Lys Ile  Gln Lys Asp 
    1115                 1120                 1125             


Lys Asp  Asn Lys Ile Lys Ile  Pro Thr His Asp Glu  Leu Thr Ile 
    1130                 1135                 1140             


Lys Leu  Val Glu Lys Leu Leu  Thr Phe Lys Phe Gln  
    1145                 1150                 1155 


<210>  1017
<211>  1155
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1017

Met Lys Leu Thr Ala Thr Lys Asn Ser Ser Asn Ala Gln Phe Tyr Arg 
1               5                   10                  15      


Asp Lys Thr Lys Gly Gln Leu Ile Ser Thr Lys Val Asn Asn Thr Ser 
            20                  25                  30          


Lys Ile Ile Glu Lys Ser Asp Lys Thr Lys Asp Ile Ile Glu Asn Leu 
        35                  40                  45              


Asp His Lys Arg Ser Leu Lys Gly Arg Ile Leu Ile Asn Pro Asp Ser 
    50                  55                  60                  


Lys Gly Lys Ile Lys Leu Asn Thr Asn Glu Phe Lys Ile Lys Ile His 
65                  70                  75                  80  


Ile Glu Lys Ile Ile Asn Thr Leu Ile Tyr Asn Asn His Met Ser Glu 
                85                  90                  95      


Leu Tyr Asp Glu Lys Pro Thr Leu Ser Asp Asp Glu Lys Lys Asp Glu 
            100                 105                 110         


Asn Leu Lys Lys Ile Ile Asn Asn Thr Leu Ser Val Tyr Gly Lys Lys 
        115                 120                 125             


Ile Lys Tyr Asn Ser Asn Ser Lys Asn Leu Glu Glu Ile Leu Ile Cys 
    130                 135                 140                 


Tyr Phe Lys Asn Glu Asp Ile Thr Ser Glu Phe Glu Asn Ile Arg Asn 
145                 150                 155                 160 


Tyr Phe Gln Thr Val Ile Thr His Lys Lys Glu Lys Leu Val Lys Ser 
                165                 170                 175     


Ile Lys Asn Asn Lys Ile Pro Phe Asp Leu Asp Asn Asn Ser Leu Gln 
            180                 185                 190         


Pro Asn Ser Glu Lys Met Lys Trp Leu Phe Ser Phe Ile Lys Asn Gly 
        195                 200                 205             


Val Ile Thr Ala Glu Ile Lys Glu Asn Thr Phe Leu Lys Asp Ile Tyr 
    210                 215                 220                 


Lys Tyr Glu Asn Leu Glu Lys Val Leu Asn Glu Glu Leu Asn Asn Gln 
225                 230                 235                 240 


Ile Lys Asn Asn Lys Pro Val Met Thr Lys Lys Leu Tyr Gln Met Val 
                245                 250                 255     


Leu Asp Tyr Asn Gln Asp Ile Tyr Ile Asn His Ile Asn Gly Glu Asn 
            260                 265                 270         


Glu Gln Asp Ser Phe Tyr Leu Asn Glu Ile Arg Glu His Phe Arg Arg 
        275                 280                 285             


Tyr Leu Val Ile Ser Lys Lys Ser Asn Thr Lys Asn Gln Asn Gly Tyr 
    290                 295                 300                 


Asn Glu Lys Ile Lys Pro Glu Lys Ile Arg His His Ile Ala Tyr Glu 
305                 310                 315                 320 


Phe Val Thr Glu Asn Ile Gln Lys His Ile Ile Asn Gln Leu Val Ala 
                325                 330                 335     


Gly Leu Ile Gln Tyr Gly Lys Leu His His Tyr Phe Tyr Asp Lys Thr 
            340                 345                 350         


Thr Ser Ser Trp Gln Lys Glu Lys Leu Asn Ser Asp Gly Leu Ser Glu 
        355                 360                 365             


Ile Gln Val Glu Glu Ala Phe Lys Lys Gln Ile Leu Thr Ser Ile Ser 
    370                 375                 380                 


Ser Gly Ile Ala Lys Leu Asn Tyr Phe Tyr Asn His Gly Ser Gln Asn 
385                 390                 395                 400 


Glu Ser Lys Ile Asn Thr Asp Lys Asn Val Asp Val Leu Asp Ser Asp 
                405                 410                 415     


Lys Val Gln Leu Gln Leu Thr Ser Asp Thr Asp Asp Thr Glu Phe Lys 
            420                 425                 430         


Ile Ser Thr Cys Phe Pro Ile Asp Leu Ala Lys Asp Tyr Leu Asn Leu 
        435                 440                 445             


Glu Lys Phe Ile Asp Thr Ile Arg Gly Asn Ile Asp Lys Ile Arg Asn 
    450                 455                 460                 


Asn Thr Phe His Phe Lys Lys Asn Glu Leu Lys Asn Leu Phe Asn Asp 
465                 470                 475                 480 


Gly Ser Tyr Asn Asn Thr Asn Ile Thr Phe Ile Lys Glu Leu Phe Gln 
                485                 490                 495     


Arg Asp Leu Asn Ser Val Gln Glu Ser Phe Lys Glu Gln Ile Arg Ser 
            500                 505                 510         


Ser Gly Ile Thr Glu Tyr Cys Ser Phe Glu Leu Leu Lys Asn Ile Phe 
        515                 520                 525             


Gln Glu Asn Ser Phe Asp Phe Gln Leu Tyr Ser Pro Gln Tyr Pro Met 
    530                 535                 540                 


Ser Pro Ser Phe Lys Asn Ile Tyr Lys Arg Gly Cys Asn Leu Ser Asn 
545                 550                 555                 560 


Ala Thr Val Lys Asp Glu Lys Ile Lys Trp Ile Lys Pro Leu Asp Ala 
                565                 570                 575     


Asp Ala Glu Asn Asp Gly Gln Leu Ala Tyr Lys Asn Leu Leu Gln Leu 
            580                 585                 590         


Ile Tyr Tyr His Cys Phe Leu Pro Tyr Val Phe Lys Asn Glu Ser Tyr 
        595                 600                 605             


Leu Ile Lys Tyr Ile Lys Thr Thr Lys Asp Trp Asn Gln Gln Lys Ala 
    610                 615                 620                 


Lys Asn Asp Arg Gln Asn Arg His Gln Tyr Arg Tyr Glu Asn Met Pro 
625                 630                 635                 640 


Phe Tyr Asn Asn Asn Lys Phe Thr Ser Leu Asn Asp Tyr Phe Gln Asn 
                645                 650                 655     


Leu Gln Arg Leu Gln Ser Ile Tyr Glu Asn Asp Glu Asp Ala Lys His 
            660                 665                 670         


Glu Asn Tyr Tyr Leu Asp Phe Ile Gln Asp Ile Phe Leu Leu Ala Phe 
        675                 680                 685             


Asp Asn Tyr Leu Glu Asp Lys Leu Lys Asn Tyr Lys Tyr Lys Leu Ile 
    690                 695                 700                 


Phe Ser Glu Lys Leu Val Asp Ser Ser Leu Glu Ser Leu Glu Thr Leu 
705                 710                 715                 720 


Glu Lys Leu Phe Glu Lys Thr Asn Thr Ile Leu Lys Met Asn Val Asn 
                725                 730                 735     


Ser Ser Phe Glu Asn Asn Leu Asn Phe Tyr Ala Phe Leu Arg Val Leu 
            740                 745                 750         


Glu Lys Arg Glu Leu Asn Asn Leu Leu His Gln Ile Ile Lys Tyr Arg 
        755                 760                 765             


Thr Ser Lys Asn Glu Glu Ser Leu Arg Glu Ile Glu Glu Leu Ile Thr 
    770                 775                 780                 


Leu Val Gln Tyr Thr Ile Pro Leu Gln Thr Ala Asp Glu His Phe Gln 
785                 790                 795                 800 


Asn Glu Leu Lys Asn His Phe Lys Tyr Phe Phe Glu Asp Glu Asn Phe 
                805                 810                 815     


Asn Asn Asn Cys Glu Leu Tyr Tyr Gln Ser Asp Lys Lys Thr Pro Ile 
            820                 825                 830         


Ala His Arg Ser Met Ser Leu Met Gly Arg Ser Gly Ile Met Ala Leu 
        835                 840                 845             


Phe Lys Val Met Phe Ser Thr Asp Tyr Lys Ile Lys Lys Glu Asp Phe 
    850                 855                 860                 


Asp Asn Tyr Leu Lys Met Ile Asp Ser Ala Glu Leu Ile Asn Asp Glu 
865                 870                 875                 880 


Thr Pro Lys Ser Ile Gln Asp Lys Gln Lys Lys Val His Asp Leu His 
                885                 890                 895     


Arg Glu Leu Val Ser Lys Lys Ile Ile Asn Ile Lys Asn Lys Asp Glu 
            900                 905                 910         


Ile Asp Lys Leu Glu Glu Tyr Glu Lys Leu Val Lys Glu Ile Lys Glu 
        915                 920                 925             


Tyr Glu His Leu Arg His Lys Leu Thr Phe Glu Thr Leu Tyr Lys Val 
    930                 935                 940                 


Tyr Lys Ile Tyr Ile Asp Ile Ile Ser Arg Leu Ala Ser Phe Ala Glu 
945                 950                 955                 960 


Asp Trp Glu Arg Asp Met Tyr Phe Met Met Ile Ala Leu Lys Glu Leu 
                965                 970                 975     


Asn His Ile Asn Gln Asn Val Asp Ile Asp Glu Ile Phe Asn Tyr Asn 
            980                 985                 990         


Pro Val Asp Lys Lys Thr Val Ser  Gln Lys Phe Lys Glu  Asn Leu Gly 
        995                 1000                 1005             


Lys Thr  Ile Lys Asn Lys Asn  Leu Val Leu Phe Leu  Phe Trp Met 
    1010                 1015                 1020             


Asp Asn  Ser Lys Asn Asn Ser  Asn Asn Phe Leu Val  Arg Asn Ser 
    1025                 1030                 1035             


Ile Ala  His Leu Asn His Met  Asn Gln Tyr Lys Leu  Asn Asp Ala 
    1040                 1045                 1050             


His Ser  Gln Lys Asn Ile Ile  Glu Leu Ile Asn Arg  Ile Arg Ile 
    1055                 1060                 1065             


Leu Leu  Ala Tyr Asp Leu Lys  Arg Gln Asn Ser Val  Thr Lys Ser 
    1070                 1075                 1080             


Ile Ile  Glu Ile Leu Glu Lys  Gln His Asp Ile Lys  Ile Lys Phe 
    1085                 1090                 1095             


Thr Gly  Lys Lys Asp Asn Asn  Asn Tyr Asn Phe Glu  Leu Asn Ser 
    1100                 1105                 1110             


Val Glu  Ser Asp Asn Ile Ile  His Leu Lys Lys Ile  Gln Lys Asp 
    1115                 1120                 1125             


Lys Asp  Asn Lys Ile Lys Ile  Pro Thr His Asp Glu  Leu Thr Ile 
    1130                 1135                 1140             


Lys Leu  Val Glu Lys Leu Leu  Thr Phe Lys Phe Gln  
    1145                 1150                 1155 


<210>  1018
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1018

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  1019
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1019

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  1020
<211>  1268
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1020

Met Lys Val Ser Lys Val Asn His Arg Arg Ala Ala Val Ala Val Asn 
1               5                   10                  15      


Lys Lys Ser Val Thr Val Asn Gly Ile Leu Tyr Asp Ala Pro Val Lys 
            20                  25                  30          


Lys Asn Val Lys Thr Gly Asn Met Ser Ala Tyr Val Ser Ser Lys Tyr 
        35                  40                  45              


Val Ile Asp Asn Val Val Lys Asn Ser Ser Arg Leu Tyr Ser Pro Phe 
    50                  55                  60                  


Ser Ser Lys Arg Ile Val Ile Asp Arg Glu Lys Ile Arg Ile Ala Asp 
65                  70                  75                  80  


Arg Leu Lys Gln Cys Tyr Val Asn Phe Val Lys Tyr Tyr Leu Ser Asn 
                85                  90                  95      


Gly Ser Leu Asn Glu Gln Gln Met Arg Phe Asn Pro Asn Asn Thr Tyr 
            100                 105                 110         


Met Ala Asp Ser Arg Val His Phe Cys Val Pro Ser Gly Ile Asp Ile 
        115                 120                 125             


Glu Ser Leu Ile Asn Ser Ile Val Asp Ser Ser Leu Arg Lys Ser Leu 
    130                 135                 140                 


Lys Arg Thr Tyr Arg Phe Glu Thr Asn Tyr Gly Glu Lys Asn Thr Phe 
145                 150                 155                 160 


Asn Leu Pro Asp Leu Val Lys Lys Ser Ile Lys Ile Tyr Cys Thr Asp 
                165                 170                 175     


Glu Lys Arg Lys Leu Asn Asp Arg Glu Glu Gln Glu Met Tyr Val Leu 
            180                 185                 190         


Phe Ser Tyr Met Tyr Glu Asp Lys Tyr Lys Asp Arg Gln Lys Val Leu 
        195                 200                 205             


Ile Ala Asn Ser Ile Ser Asn Gln Ala Thr Lys Val Lys Val Cys Asp 
    210                 215                 220                 


Asp Glu Ser Arg Leu Ile Lys Leu Ser Ile Ala Asp Thr Lys Lys Lys 
225                 230                 235                 240 


Pro Leu Trp Asp Phe Ile Val Asp Tyr Ala Asn Ser Asp Lys Asn Gly 
                245                 250                 255     


Gln Tyr Thr Ile Leu Arg Asn Ile Arg Lys Ser Ile Val Leu Phe Val 
            260                 265                 270         


Cys Gly Val Asp Val Tyr Arg Asn Ile Glu Asn Asn Asp Asn Leu Asp 
        275                 280                 285             


Ile Trp Lys Trp Glu Glu Tyr Gly Ile Gln Glu Ser Gln Leu Phe Val 
    290                 295                 300                 


Lys Ile Glu Asn Cys Tyr Thr Thr Lys Gly Glu Asp Ile Ala Leu Asn 
305                 310                 315                 320 


Glu Ile Arg Asn Val Asn Leu Asp His Tyr Met Lys Ala Ile Gly Val 
                325                 330                 335     


Leu Asp Asp Glu Arg Ser Lys Phe Trp Phe Gln His Tyr Glu Asn Thr 
            340                 345                 350         


Ile Glu Ala Leu Phe Ser Lys Lys Ser Lys Arg Lys Ile Glu Arg Ile 
        355                 360                 365             


Lys Thr Ala Tyr Leu Cys Glu Tyr Leu Trp Lys Asn Phe Cys Ser Tyr 
    370                 375                 380                 


Val Ala Leu Lys Tyr Val Asp Leu Gly Lys Gly Val Tyr His Phe Thr 
385                 390                 395                 400 


Met Ser Asp Lys Leu Ser Leu Met Asn Lys Asn Thr Asn Glu Asn Gly 
                405                 410                 415     


Ile Lys Phe Gly Glu Val Asp Ser Arg Phe Asn Lys Gly Ile Ser Ser 
            420                 425                 430         


Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Thr Ile Asp Arg Asn Ile 
        435                 440                 445             


Ser Thr Tyr Thr Thr Phe Ala Thr Asn Ile Phe Ala Lys Ser Val Ile 
    450                 455                 460                 


Lys Asp Ser Tyr Arg Gln Lys Lys Ala Gly Asn Ser Asp Ala Leu Gln 
465                 470                 475                 480 


Tyr Asp Asp Glu Thr Tyr Tyr Asn Arg Lys Ala Met Asn Pro Tyr Ala 
                485                 490                 495     


Leu Lys Arg Val Leu Arg Tyr Trp Gly Gly Gln Ser Arg Trp Lys Ser 
            500                 505                 510         


Glu Leu Glu Glu Leu Asn Val Ala Glu Leu Cys Ile Asp Ile Lys Asn 
        515                 520                 525             


Arg Leu Ser Lys Ile Arg Asn Ser Gly Val His Tyr Thr Ser Thr Ser 
    530                 535                 540                 


Ala Leu Lys Gly Asn Asp Asp Asp Ser Ile Val Gly Met Leu Ile Lys 
545                 550                 555                 560 


Lys Asp Phe Asp Asp Ile Lys Asp Val Tyr Ala Ser Lys Tyr Tyr Ser 
                565                 570                 575     


Asn Asn Val Trp Met Phe Tyr Asn Thr Asp Lys Ile Ser Lys Met Met 
            580                 585                 590         


Glu Tyr Leu Tyr Gln Asp Asp Ser Asn Ile Arg Asp Ala Gln Ile Pro 
        595                 600                 605             


Ala Phe Asn Ser Val Ile Lys Arg Lys Asp Met Ala Glu Val Ile Glu 
    610                 615                 620                 


Lys Ile Val Lys Lys Asn Ser Tyr Lys Thr Ile Lys Glu Pro Tyr Gln 
625                 630                 635                 640 


Arg Glu Lys Tyr Arg Ser Cys Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
                645                 650                 655     


Tyr Asn Arg Phe Ile Lys Gln Asp Asn Leu Lys Asp Gln Val Ile Gln 
            660                 665                 670         


Ile Ile Asp Ser Asn Thr Glu Leu Ile Gly Asp Asn Ser Arg Ala Val 
        675                 680                 685             


Asp Asn Leu Lys Lys Arg Ile His Asp Val Asp Ser Gln Thr Met Ser 
    690                 695                 700                 


Phe Gly Glu Leu Cys Gln Val Ile Met Thr Asp Tyr Asn Met Gln Asn 
705                 710                 715                 720 


Gln Glu Asn Lys Ser Ile Lys Ser Lys Glu Arg Gln Asp Lys Asp Arg 
                725                 730                 735     


Lys Asn Gly Ile Asp Asn Ser Tyr Lys His Phe Pro Leu Leu Leu His 
            740                 745                 750         


His Leu Ile Lys Val Ser Phe Leu Lys Phe Ile Lys Thr Asp Glu Lys 
        755                 760                 765             


Leu Ala Phe Ile Arg Glu Pro Arg Ile Thr Glu Trp Asp Lys Thr Leu 
    770                 775                 780                 


Glu Gln Phe Glu Ala Gln Ile Gln Thr Val Asp Ile Tyr Asn Ser Leu 
785                 790                 795                 800 


Lys Met Met Val Ala Glu Asn Lys Ser Leu Leu Asp Trp Tyr Thr Leu 
                805                 810                 815     


Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asp Val 
            820                 825                 830         


Lys Asn Tyr Ile Gln Tyr Leu Ser Asn Ile Asp Lys Arg Ala Gly Ser 
        835                 840                 845             


Val Lys Asn Asn Lys Ser Ala Ser Thr Glu Val Lys Ile Arg Gln Tyr 
    850                 855                 860                 


Ser Glu Ile Val Arg Ile Leu Asp Phe Ser Leu Gln Tyr Ile Gly Arg 
865                 870                 875                 880 


Val Ser Asn Asp Val Thr Asp Tyr Phe Val Asp Glu Asp Glu Tyr Ala 
                885                 890                 895     


Ala Phe Leu Ser Lys Tyr Val Glu Phe Ser Gly Asn Asp Ile Val Ser 
            900                 905                 910         


Met Lys Ala Phe Cys Gln Ser Arg Thr Ala Asn Gly Lys His Thr Ile 
        915                 920                 925             


Gly Leu Tyr Cys Asp Gly Ala Asn Pro Ile Met Asn Arg Asn Ile Ala 
    930                 935                 940                 


Tyr Ala Lys Met Tyr Gly Asn Asp Glu Ile Leu Ser Tyr Ile Tyr Asn 
945                 950                 955                 960 


Lys Val Thr Lys Lys Asp Ile Glu Lys Tyr Tyr Val Ser Gln Asp Asn 
                965                 970                 975     


Leu Glu Lys Val Phe Ala Asp Gly Lys Cys Gln Asp Val Gln Gln Gln 
            980                 985                 990         


Asn Ala Leu Cys Asp Phe Gln Lys  Met Lys Asn His Ile  Glu Leu Thr 
        995                 1000                 1005             


Glu Val  Ser Ile Tyr Thr Asp  Ile Leu Asn Asp Phe  Met Ala Gln 
    1010                 1015                 1020             


Phe Ile  Ser Trp Ala Tyr Leu  Arg Glu Arg Asp Leu  Met Tyr Phe 
    1025                 1030                 1035             


Gln Leu  Gly Leu Asn Tyr Ile  Arg Met Phe Tyr Gly  Thr Tyr Glu 
    1040                 1045                 1050             


Leu Glu  Glu Lys Tyr Tyr Lys  Leu His Gly Glu Asn  Ile Asn Ile 
    1055                 1060                 1065             


Glu Lys  Gly Ala Leu Leu Tyr  Gln Ile Val Ala Met  Tyr Ser His 
    1070                 1075                 1080             


Glu Leu  Pro Ile Tyr Lys Val  Asp Glu Ser Gly Ile  Ala Ile Leu 
    1085                 1090                 1095             


Ala Glu  Lys Gln Gly Ser Ser  Gly Ala Ser Ile Lys  Ser Phe Val 
    1100                 1105                 1110             


Thr Glu  Tyr Cys Lys Glu Glu  Met Lys Lys Ala Tyr  Thr Tyr Glu 
    1115                 1120                 1125             


Asn Gly  Leu Glu Leu Phe Glu  Asp Val Asn Gln His  Asp Asp Leu 
    1130                 1135                 1140             


Ser Lys  Leu Arg Asn Asp Phe  Ala His Met Arg Tyr  Met Ser Ala 
    1145                 1150                 1155             


Arg Asp  Lys Ser Ile Met Asp  Ile Val Ser Glu Ile  Tyr Asn Gly 
    1160                 1165                 1170             


Phe Phe  Ile Tyr Asp Thr Lys  Leu Lys Lys Ser Val  Ser Phe Ile 
    1175                 1180                 1185             


Phe Lys  Asn Ile Leu Met Arg  Tyr Ala Val Asp Val  Asn Ile Glu 
    1190                 1195                 1200             


Phe Cys  His Lys Gly Asp Asn  Glu Asp Thr Asn Asn  Leu Ile Arg 
    1205                 1210                 1215             


Ile Lys  Asp Glu Val Gly Leu  Tyr Ser Asp Lys Tyr  Thr Tyr Lys 
    1220                 1225                 1230             


Val Glu  Asp Asn Asp Thr Val  Asp Ile Glu Val Arg  Asn Ser Glu 
    1235                 1240                 1245             


Phe Leu  Glu Gln Leu Lys Lys  Leu Leu Glu Tyr Lys  Lys Glu Ser 
    1250                 1255                 1260             


Glu Gly  Ser Glu Leu 
    1265             


<210>  1021
<211>  1101
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1021

Met Arg Ile Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Ile Tyr Ser Glu 
            20                  25                  30          


Gln Ala Val Ser Asn Glu Thr Asn Asn Ile Leu Pro Val Lys Lys Met 
        35                  40                  45              


Asp Ser Phe Asn Leu Ser Ile Leu Asn Lys Thr Ile Ile Lys Phe Glu 
    50                  55                  60                  


Thr Val Lys Lys Gln Lys Leu Asn Leu Asp Gln Tyr Lys Ile Val Glu 
65                  70                  75                  80  


Lys Ile Phe Lys Tyr Pro Lys Gln Glu Leu Pro Lys Gln Ile Asn Ala 
                85                  90                  95      


Glu Glu Ile Leu Gln Phe Leu Asn His Lys Phe Gln Glu Pro Val Lys 
            100                 105                 110         


Tyr Trp Lys Asn Gly Lys Glu Glu Ser Phe Asn Leu Thr Leu Leu Ile 
        115                 120                 125             


Val Glu Ala Val Lys Thr Gln Glu Lys Arg Lys Leu Gln Pro Tyr Tyr 
    130                 135                 140                 


Asp Trp Lys Thr Trp Tyr Ile Gln Thr Lys Ser Asp Leu Leu Lys Lys 
145                 150                 155                 160 


Ser Ile Glu Asn Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg 
                165                 170                 175     


Lys Lys Ala Leu Leu Ala Trp Glu Thr Glu Phe Thr Thr Ser Gly Ser 
            180                 185                 190         


Ile Asp Leu Thr His Phe His Lys Val Tyr Met Thr Asp Val Leu Cys 
        195                 200                 205             


Thr Ala Leu Gln Lys Val Glu Pro Ser Ala Asp Glu Arg Gly Lys Met 
    210                 215                 220                 


Asn Ser Asn Ala Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Asn His 
225                 230                 235                 240 


Gln Pro Ala Ile Phe Gly Thr Arg Glu Ala Pro Asn Glu Val Asn Arg 
                245                 250                 255     


Ala Asp Asn Gln Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu 
            260                 265                 270         


Glu His Tyr Phe Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Ala Asp 
        275                 280                 285             


Asp Ile Ser His Tyr Leu Lys Ala Gln Thr Leu Lys Thr Thr Ile Glu 
    290                 295                 300                 


Lys Gln Leu Val Asn Ala Ile Arg Ala Asn Ile Ile Gln Gln Gly Lys 
305                 310                 315                 320 


Thr Asn His His Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile 
                325                 330                 335     


Arg Ile Lys Thr Asn Glu Ala Phe Val Leu Asn Leu Ile Gly Thr Cys 
            340                 345                 350         


Ala Phe Ala Ala Asn Asn Ile Arg Asn Met Val Asp Lys Glu Gln Ile 
        355                 360                 365             


Ser Asp Ile Leu Gly Lys Arg Glu Phe Ile Asp Ser Leu Thr Lys Ser 
    370                 375                 380                 


Arg Ile Ser Ser Gln Leu Tyr Ser Phe Phe Phe Gly Glu Asn Leu Ser 
385                 390                 395                 400 


Thr Asn Lys Ala Glu Lys Glu Thr Gln Leu Trp Gly Ile Arg Gly Ala 
                405                 410                 415     


Val Gln Gln Ile Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu 
            420                 425                 430         


Thr Thr Ile Phe Asn Ile Cys Lys Phe Glu Asn Pro Thr Asp Ala Asp 
        435                 440                 445             


Pro Lys Gln Gln Thr Asn Tyr Val Asp Ser Ile Tyr Lys Thr Leu Phe 
    450                 455                 460                 


Ile Lys Glu Leu Glu Lys Ile Pro Glu Ala Phe Ala Gln Gln Leu Lys 
465                 470                 475                 480 


Thr Gly Gly Ala Leu Ser Tyr Tyr Thr Val Glu Asn Leu Lys Thr Leu 
                485                 490                 495     


Leu Thr Thr Phe Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala 
            500                 505                 510         


Pro Gly Phe Lys Lys Val Leu Asn Gly Gly Ile Asn Tyr Gln Asn Ala 
        515                 520                 525             


Lys Gln Asp Glu Ser Phe Tyr Glu Leu Met Leu Glu Arg Tyr Leu Arg 
    530                 535                 540                 


Lys Glu Asn Phe Ala Glu Glu Ala Tyr Asn Ala Arg Tyr Phe Leu Leu 
545                 550                 555                 560 


Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Lys Phe Thr Ala Asp Arg 
                565                 570                 575     


Lys Ala Phe Ala Asp Ser Val Gly Phe Val Gln Leu Gln Asn Arg Lys 
            580                 585                 590         


Gln Ala Glu Asn Ser Lys Arg Pro Lys Ala Phe Ala Phe Glu Ala Val 
        595                 600                 605             


Arg Pro Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala Tyr Val 
    610                 615                 620                 


Gln Ser Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys Ala Thr 
625                 630                 635                 640 


Asp Glu Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val Phe Ile 
                645                 650                 655     


Lys Gly Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe Val Gln 
            660                 665                 670         


Val Pro Gln Pro Gln Leu Thr Thr Thr Asp Ser Asn Gln Gln Lys Ala 
        675                 680                 685             


Asp Lys Leu Asn Gln Leu Glu Ala Ser Ile Thr Ala Asp Cys Lys Leu 
    690                 695                 700                 


Thr Ala Gln Tyr Ala Lys Thr Asp Asp Ala Thr His Ile Ala Phe Tyr 
705                 710                 715                 720 


Val Phe Cys Lys Leu Leu Asp Ala Gly His Leu Ser Asn Leu Arg Asn 
                725                 730                 735     


Glu Leu Ile Lys Phe Arg Gly Ser Val Lys Asp Phe Asp Phe His His 
            740                 745                 750         


Leu Leu Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val Val Pro 
        755                 760                 765             


Thr Asp Tyr Arg Asp Leu Tyr Ser Ser Gly Ala Asp Cys Leu Ala Arg 
    770                 775                 780                 


Leu Arg Pro Phe Ile Glu Gln Gly Ala Asp Ile Lys Asn Trp Ser Asp 
785                 790                 795                 800 


Leu Tyr Val Gln Thr Asp Lys Gln Thr Pro Val Ile His Ala Gly Ile 
                805                 810                 815     


Glu Leu Ser Val Lys Tyr Gly Thr Thr Ala Leu Leu Glu Gln Leu Ile 
            820                 825                 830         


Thr Cys Asn Pro Lys Phe Arg Val Met Glu Asp Asn Phe Thr Lys Trp 
        835                 840                 845             


Ser Ala Gln Lys Lys Glu Ile Glu Glu Lys Val Asn Lys His Thr Asn 
    850                 855                 860                 


Leu His Gln Gln Trp Val Glu Ala Lys Glu Lys Asp Asp Arg Glu Arg 
865                 870                 875                 880 


Val Lys Ser Lys Lys Asn Phe Val Arg Glu Tyr Val Lys Lys Asn Tyr 
                885                 890                 895     


Val Asp Tyr Ile Asn Asn Cys Ile Glu Ile Asn Asn Tyr Asn Trp Leu 
            900                 905                 910         


Asp Asn Lys Leu His Phe Val His Leu Asn His Leu His His Leu Thr 
        915                 920                 925             


Ile Asp Ile Leu Gly Arg Met Ala Gly Phe Val Ala Leu Trp Glu Arg 
    930                 935                 940                 


Asp Phe Gln Tyr Ile Thr Lys Tyr Thr Ala Ala Lys Glu Gly Thr Asp 
945                 950                 955                 960 


Ala Leu Ser Phe Asp Gly Gly Leu Pro Arg Leu Lys Asp Lys Gln Glu 
                965                 970                 975     


Tyr Tyr Asn Lys Leu Phe Leu Ser Asp Lys Tyr Thr Lys Val Arg Asn 
            980                 985                 990         


His Ile Ala His Phe Asn Tyr Leu  Thr Lys Asp Ala Ala  Asp Phe Ala 
        995                 1000                 1005             


Leu Leu  Asp Leu Ile Asn Glu  Leu Arg Glu Leu Leu  His Tyr Gly 
    1010                 1015                 1020             


Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ala Phe Ile  Asp Leu Phe 
    1025                 1030                 1035             


Glu Lys  His Gly Met Ile Leu  Lys Leu Lys Leu Asn  Thr Asp His 
    1040                 1045                 1050             


Gln Leu  Val Val Glu Ser Ile  Glu Pro Lys Lys Ile  Tyr His Leu 
    1055                 1060                 1065             


Gly Ser  Thr Ala Lys Asp Lys  Pro Glu Tyr Gln Tyr  Thr Thr Asn 
    1070                 1075                 1080             


Gln Val  Met Thr Val Tyr Cys  Asn Met Cys Arg Ser  Leu Leu Glu 
    1085                 1090                 1095             


Met Lys  Lys 
    1100     


<210>  1022
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1022

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Thr Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Tyr Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asn Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Val Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Val 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Lys Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Met 
    690                 695                 700                 


Tyr Ile Gly Asn Asp Glu Gln Ile Asn Thr Ser Leu Ala Gly Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Lys Ile Leu Lys Tyr Thr Glu Ser Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Lys Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Leu Lys Glu Leu Lys Glu Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn Tyr Thr Met Gln Gln Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Lys Lys Asp Glu Lys Phe Asn Asp Glu Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Ile Met Lys Ser  Val Val Asn Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Lys Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Lys Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Glu  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  1023
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1023

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Tyr Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  1024
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1024

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  1025
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1025

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Gly Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Lys Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asp 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  1026
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1026

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  1027
<211>  1139
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1027

Met Lys Ile Thr Lys Ile Asp Gly Ile Ser His Lys Lys Tyr Lys Glu 
1               5                   10                  15      


Lys Gly Lys Leu Ile Lys Ser Asn Glu Ile Glu Lys Asp Val Thr Glu 
            20                  25                  30          


Glu Arg Phe Tyr Asp Ile Lys Thr Lys Thr Thr Glu Leu Phe Leu Lys 
        35                  40                  45              


Thr Leu Asp Phe Tyr Val Lys Asn Tyr Glu Gln Cys Glu Glu Gln Asn 
    50                  55                  60                  


Lys Glu Arg Arg Glu Lys Ala Lys Asn Tyr Phe Ser Lys Val Lys Leu 
65                  70                  75                  80  


Ile Ile Glu Asn Arg Lys Ile Thr Ile Phe Asn Glu Asn Thr Glu Lys 
                85                  90                  95      


Ile Glu Ile Glu Gly Phe Asn Glu Tyr Asp Val Arg Asp Glu Lys Tyr 
            100                 105                 110         


Phe Asn Val Leu Asn Lys Ile Leu Lys Glu Glu Asn Cys Thr Glu Glu 
        115                 120                 125             


Asp Leu Glu Val Phe Glu Asn Asp Leu Gln Lys Lys Leu Asn Gln Ile 
    130                 135                 140                 


Gln Ser Ile Lys Asn Ser Leu Glu Glu Asn Lys Ala His Phe Lys Lys 
145                 150                 155                 160 


Glu Ser Val Asn Asn Thr Ala Asp Arg Val Lys Gly Asn Asn Lys Lys 
                165                 170                 175     


Ser Leu Phe Tyr Glu Tyr Tyr Arg Ile Ser Ser Lys His Gln Glu Tyr 
            180                 185                 190         


Ala Asn Asn Ile Phe Glu Ala Phe Asp Lys Leu Tyr Ser Asn Ser His 
        195                 200                 205             


Glu Ala Met Asn Asn Leu Phe Ser Glu Ile Thr Lys Asp Ser Lys Asp 
    210                 215                 220                 


Arg Asn Ile Arg Lys Ile Arg Glu Ala Tyr His Glu Ile Leu Asn Lys 
225                 230                 235                 240 


Asn Lys Thr Glu Phe Gly Glu Glu Leu Tyr Lys Lys Ile Gln Asp Asn 
                245                 250                 255     


Arg Asn Asn Phe Asp Lys Leu Leu Glu Ile Glu Pro Glu Ile Lys Glu 
            260                 265                 270         


Leu Thr Lys Ser Gln Ile Phe Tyr Lys Tyr Tyr Ile Asp Lys Val Asn 
        275                 280                 285             


Leu Asp Glu Thr Ser Ile Lys His Cys Phe Cys His Leu Val Glu Ile 
    290                 295                 300                 


Glu Val Asn Gln Leu Leu Lys Asn Tyr Val Tyr Ser Lys Arg Asn Ile 
305                 310                 315                 320 


Asn Lys Glu Lys Leu Glu Asn Ile Phe Glu Tyr Cys Lys Leu Arg Asn 
                325                 330                 335     


Leu Val Lys Asn Lys Leu Val Asn Lys Leu Asn Asn Tyr Ile Arg Asn 
            340                 345                 350         


Cys Gly Lys Tyr Asn Ala Tyr Ile Ser Asn Asn Asp Val Val Val Asn 
        355                 360                 365             


Ser Glu Lys Ile Ser Glu Ile Arg Thr Lys Glu Ala Phe Leu Arg Ser 
    370                 375                 380                 


Ile Ile Gly Val Ser Ser Ser Ala Tyr Phe Ser Leu Arg Asn Ile Leu 
385                 390                 395                 400 


Asn Thr Asp Asn Thr Gln Asp Ile Thr Asn Lys Val Asp Lys Glu Val 
                405                 410                 415     


Asp Lys Leu Tyr Gln Glu Asn Lys Lys Ile Glu Leu Glu Glu Ile Leu 
            420                 425                 430         


Lys Leu Phe Phe Gly Asn Tyr Phe Asp Ile Asn Asn Gln Gln Glu Ile 
        435                 440                 445             


Lys Val Phe Leu Met Asn Ile Asp Lys Ile Ile Ser Ser Ile Arg His 
    450                 455                 460                 


Glu Ile Ile His Phe Lys Met Glu Thr Asn Ala Gln Asn Ile Phe Asp 
465                 470                 475                 480 


Phe Asn Asn Val Asn Leu Gly Asn Thr Ala Lys Asn Ile Phe Ser Asn 
                485                 490                 495     


Glu Ile Asn Glu Glu Lys Ile Lys Phe Lys Ile Phe Lys Gln Leu Asn 
            500                 505                 510         


Ser Ala Asn Val Phe Asp Tyr Leu Ser Asn Lys Asp Ile Thr Glu Tyr 
        515                 520                 525             


Met Asp Lys Val Val Phe Ser Phe Thr Asn Arg Asn Val Ser Phe Val 
    530                 535                 540                 


Pro Ser Phe Thr Lys Ile Tyr Asn Arg Val Gln Asp Leu Ala Asn Ser 
545                 550                 555                 560 


Leu Glu Ile Lys Glu Trp Lys Ile Pro Asp Glu Ser Glu Gly Lys Asp 
                565                 570                 575     


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Lys Phe Leu Asp 
            580                 585                 590         


Lys Phe Leu Asn Glu Glu Asn Gly Ile Phe Ile Ser Val Lys Asp Lys 
        595                 600                 605             


Ile Thr Gly Phe Tyr Lys Leu Glu Lys Phe Glu Lys Ile Glu Glu Thr 
    610                 615                 620                 


Asn Pro Lys Lys Tyr Leu Glu Ile Ile Gln Ser Leu Tyr Met Ile Asn 
625                 630                 635                 640 


Ile Glu Glu Ile Asp Ser Glu Gly Lys Asn Ile Phe Leu Asp Phe Ile 
                645                 650                 655     


Gln Lys Ile Phe Leu Lys Gly Phe Phe Glu Phe Ile Lys Asn Asp Tyr 
            660                 665                 670         


Asn Tyr Leu Leu Glu Leu Lys Lys Val Gln Asp Lys Lys Asn Ile Phe 
        675                 680                 685             


Asp Ser Lys Met Ser Glu Tyr Ile Ala Gly Glu Lys Thr Leu Glu Asp 
    690                 695                 700                 


Met Glu Glu Ile Asn Glu Ile Ile Gln Asp Ile Lys Ile Thr Glu Ile 
705                 710                 715                 720 


Asp Lys Ile Leu Asn Gln Thr Asp Lys Ile Asn Cys Phe Tyr Leu Leu 
                725                 730                 735     


Leu Lys Leu Leu Asn Tyr Lys Glu Ile Thr Glu Leu Lys Gly Asn Leu 
            740                 745                 750         


Glu Lys Tyr Gln Ile Leu Ser Lys Ala Asn Val Tyr Glu Lys Glu Leu 
        755                 760                 765             


Met Leu Leu Asn Ile Val Asn Leu Asp Asn Asn Lys Val Lys Ile Glu 
    770                 775                 780                 


Asn Phe Lys Ile Ser Ala Glu Glu Ile Gly Lys Phe Ile Glu Lys Ile 
785                 790                 795                 800 


Asn Ile Glu Glu Ile Asn Lys Lys Ile Lys Thr Phe Gly Glu Leu Arg 
                805                 810                 815     


Asn Phe Glu Lys Gly Glu Asn Thr Gly Glu Tyr Tyr Asn Ile Tyr Ser 
            820                 825                 830         


Asp Asp Lys Asn Ile Lys Asn Ile Arg Asn Leu Tyr Asn Ile Lys Lys 
        835                 840                 845             


Tyr Gly Met Leu Asp Leu Leu Glu Lys Ile Ser Glu Lys Thr Asn Tyr 
    850                 855                 860                 


Cys Ile Lys Lys Lys Asp Leu Lys Glu Tyr Ser Lys Leu Arg Lys Gln 
865                 870                 875                 880 


Leu Glu Asp Lys Lys Lys Glu Asn Glu Lys Ile Glu Asp Glu Lys Thr 
                885                 890                 895     


Asn Phe Tyr Lys Ile Gln Glu Tyr Leu His Ser Lys Tyr Gln Gln Glu 
            900                 905                 910         


Pro Lys Lys Ile Leu Trp Lys Lys Asn Lys Asn Asp Tyr Glu Lys Tyr 
        915                 920                 925             


Lys Lys Ser Ile Glu Asn Ile Glu Lys Tyr Val His Leu Lys Asn Lys 
    930                 935                 940                 


Ile Glu Phe Asn Glu Leu Asn Leu Leu Gln Ser Leu Leu Leu Lys Ile 
945                 950                 955                 960 


Leu His Arg Leu Ala Gly Phe Thr Ser Ile Trp Glu Arg Asp Leu Arg 
                965                 970                 975     


Phe Arg Leu Thr Gly Glu Phe Pro Asp Glu Leu Asp Val Glu Asp Ile 
            980                 985                 990         


Phe Asn His Arg Lys Arg Tyr Lys  Gly Thr Gly Lys Gly  Ile Cys Lys 
        995                 1000                 1005             


Lys Tyr  Asp Arg Phe Ile Asn  Thr His Thr Glu Tyr  Lys Asn Asn 
    1010                 1015                 1020             


Asn Lys  Met Lys Asn Val Lys  Phe Val Asp Asp Asn  Pro Val Arg 
    1025                 1030                 1035             


Asn Tyr  Ile Ala His Phe Asn  Tyr Leu Pro Thr Pro  Lys Tyr Ser 
    1040                 1045                 1050             


Ile Leu  Lys Met Met Glu Lys  Leu Arg Lys Leu Leu  Asp Tyr Asp 
    1055                 1060                 1065             


Arg Lys  Leu Lys Asn Ala Val  Met Lys Ser Ile Lys  Asp Ile Leu 
    1070                 1075                 1080             


Glu Glu  Tyr Gly Phe Lys Ala  Glu Phe Ile Ile Asn  Ser Asp Lys 
    1085                 1090                 1095             


Glu Ile  Ile Leu Asn Ser Val  Lys Ser Val Glu Ile  Ile His Leu 
    1100                 1105                 1110             


Gly Lys  Glu Asp Leu Lys Ser  His Arg Asn Ser Glu  Asp Leu Cys 
    1115                 1120                 1125             


Lys Leu  Val Lys Ala Met Leu  Glu Tyr Ser Glu 
    1130                 1135                 


<210>  1028
<211>  1256
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1028

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Lys Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn Gln Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Asn Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Gly Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Gln Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Val Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Leu 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Tyr Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Met Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Ala Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Ser Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asn 
785                 790                 795                 800 


Ser Ile Phe Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Val Ala Asn Ala Phe Ala Leu Tyr Leu Gln Asn Asn Lys Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asp Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Asp Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asn Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Met Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Glu  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Ala Gln Gly  Gly Ala Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Arg Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Lys Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Met Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Lys Tyr Phe  Thr 
    1250                 1255     


<210>  1029
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1029

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Asn Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Ile Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Ser Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Lys Ile Pro Tyr Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Asn Asp Lys Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr Tyr Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Glu Leu  Lys Lys Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Val Lys Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Lys Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Glu  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  1030
<211>  1315
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1030

Met Ile Ile Ile Lys Lys Phe Gly Arg Ser Val Ile Thr Gln Asp Lys 
1               5                   10                  15      


Asn Thr Asp Asn Lys Arg Glu Arg Glu Leu Asp Thr Ser Ala Arg Ala 
            20                  25                  30          


Lys Ala Lys Ser Gln Asn Ser Gln Val Phe Pro Phe Leu Asn Lys Lys 
        35                  40                  45              


Glu Asp Phe Ile Asn Leu Trp Ile Ser Glu Phe Asp Lys Leu Ile Tyr 
    50                  55                  60                  


Lys Pro Lys Gly Asp Asp Lys Pro Thr Lys Glu Met Tyr Thr Leu Arg 
65                  70                  75                  80  


Glu Ala Ala Gly Lys Gly Phe Leu Asn Tyr Trp Asn Gln Met Pro Met 
                85                  90                  95      


Val Ser Lys Lys Asp Gly Ala Phe Ser Asp Met Trp Met Ser Lys Val 
            100                 105                 110         


His Pro Tyr Gly Arg Gly Ile Thr Glu Phe Ser Pro Pro Leu Gln Leu 
        115                 120                 125             


Glu Lys Leu Ile Asp Gln Gly Leu Leu Ser Ala Met Gly Gly Ser Glu 
    130                 135                 140                 


Pro Leu Lys Asn Cys His Trp Asn Arg Val Thr Ser Asn Val Phe Lys 
145                 150                 155                 160 


Gly Leu Lys Val Gln Leu Asp Ile Leu Glu Ala Gln Ala Lys Asn Thr 
                165                 170                 175     


Phe Val Ile Lys Asn Lys Thr Asn Ser Lys Arg Asn Arg Pro Ala Ser 
            180                 185                 190         


Gln Asn Ile Lys Glu Phe Leu Leu Thr Asp Glu Thr Ala Phe Ile Asn 
        195                 200                 205             


Leu Trp Ile Ser Glu Phe Asp Lys Leu Ile Leu Lys Pro Gln Gly His 
    210                 215                 220                 


Asn Lys Pro Thr Glu Lys Met Tyr Asn Leu Arg Gln Gln Ala Gly Val 
225                 230                 235                 240 


Ala Phe Leu Asn Tyr Trp Lys Lys Lys Pro Leu Ile Pro Trp Ala Asn 
                245                 250                 255     


Ser Glu Ser Phe Pro Asp Lys Trp Met Leu Lys Val His Pro Tyr Gly 
            260                 265                 270         


Asp Lys Thr Ser Asn Asn Arg Ser Glu Thr Leu Ile Lys Ser Lys Trp 
        275                 280                 285             


Gly Ser Val Met Arg Ala Lys Glu Cys Leu Ser Asp Asp Gln Trp Glu 
    290                 295                 300                 


Gln Val Ala Phe Asn Val Tyr Ser His Leu Tyr Gly Asn Gln Lys Thr 
305                 310                 315                 320 


Leu Asn Gly Lys Asn Lys Glu Ile Gly Leu Ile Ala Ala Arg Ala Asn 
                325                 330                 335     


Ser Ile Lys Gln Asn Val Pro Ser Tyr Thr Leu Asp Lys Asp Asn Asn 
            340                 345                 350         


Phe Leu Ser Asp Lys Lys Asp Lys Leu Arg Tyr Ile Ala Ala Leu Arg 
        355                 360                 365             


Gly Glu Gly Ile Lys Trp Glu Glu Val Lys Asp Arg Tyr Lys Trp Lys 
    370                 375                 380                 


Glu Leu Thr Gln Leu Ile Asn Ile Glu Glu Ile Asp Ser Thr Asp Ile 
385                 390                 395                 400 


Ala Lys Arg Lys Gln His Leu Ala Glu Cys Phe Tyr Thr His His Gly 
                405                 410                 415     


Arg Ile Phe Gly Asp Ile Gln Asn Ser Lys Ile Glu Asp Lys Asp Cys 
            420                 425                 430         


Phe Leu Tyr His Ser Leu Val Lys Glu Ile Leu Phe Glu Cys Ile Glu 
        435                 440                 445             


Lys Lys Gln Asp Phe Leu Asn Asp Thr Glu Val His Gln Arg Leu Ile 
    450                 455                 460                 


Tyr Lys Glu Asn Asn Arg Ile Met Ala Thr Ala Val Ser Ile Gly Lys 
465                 470                 475                 480 


Leu Ile His Tyr Gln Gly Gly Ile Glu Ala Ile Gly Asn Lys Glu Asp 
                485                 490                 495     


Leu Val Asn Ser Lys Phe Leu Thr Asp Ala Gly Leu Thr Glu Ile Lys 
            500                 505                 510         


Gln Asn Glu Ser Phe Val Arg Gln Trp Leu Glu Leu Ile Ala Ile Ala 
        515                 520                 525             


Asn Thr Thr Leu Ser Gln Leu Val Asp Pro Asp Gly Lys His Glu Asp 
    530                 535                 540                 


Ile Phe Ala Ala Thr Ser Phe Asp Asp Ala Leu Lys Gly Leu Asn Asn 
545                 550                 555                 560 


Ile Ser Asp Phe Asp Ser Lys Phe Lys Leu Leu Phe Gly Glu Asn His 
                565                 570                 575     


Arg Leu Tyr Asp Asp Asp Thr Glu Arg Gln Lys Leu Leu Arg Ile Ile 
            580                 585                 590         


Tyr Asp Thr Ile Ser Ala Leu Arg Asn Ala Ser Phe His Phe Lys Asn 
        595                 600                 605             


Ile Gln Gly Phe Asn Lys Ala Leu Glu Asp Asn Leu Ser Thr Lys Gly 
    610                 615                 620                 


Arg Arg Gln Lys Gly Val Val Asp Lys Ile Ile Glu Tyr Thr Lys Val 
625                 630                 635                 640 


His Gln Gln Lys Gln His Glu Leu Leu Ile Ala Asp Leu Lys Ala Ala 
                645                 650                 655     


Asn Val Glu Asp Tyr Leu Ser Gln Leu Gln Leu Asp Tyr Leu Phe Glu 
            660                 665                 670         


Val Val Cys Lys Gly Glu Arg Glu Leu Leu Asp Met Pro Lys Phe Ser 
        675                 680                 685             


Lys Leu Leu Leu Arg Ala Gly Glu Ile Gly Glu Lys Ile Ile Ser Pro 
    690                 695                 700                 


Val Asn Ala Thr Ala Met Glu His Pro Ala Tyr Gln Cys Cys Phe Ile 
705                 710                 715                 720 


Ser Leu Lys Met Leu Tyr Asp Gln Asp Phe Val Asn Trp Leu Lys Lys 
                725                 730                 735     


Gln Ser Asn Lys Asn Ile Ala Ser Trp Met Asp Ser Ala Lys Thr Arg 
            740                 745                 750         


Ala Thr Asn Ala Ala Lys Lys Ile Phe Arg Asn Gly Thr Asn Ile Ser 
        755                 760                 765             


Ser Lys Met Ala Arg Leu Arg Asn Ile Val Glu Asp Glu Thr Leu Val 
    770                 775                 780                 


Glu Tyr Phe Ser Phe Ile Thr Ala Glu Thr Ala Asn Glu Phe Gln Val 
785                 790                 795                 800 


Gln Gln Gln Lys Asn Arg Tyr Gln Ser Asn Ser Ala Ser Ala Lys Glu 
                805                 810                 815     


Gln Ser Asn Phe Val Glu Gln Phe Lys Gln Asp Phe Leu Ile Tyr Ala 
            820                 825                 830         


Phe Lys Gly Tyr Ile Gly Asp Ile Lys Phe Gly Lys Leu Asp Gln Gly 
        835                 840                 845             


Glu Lys Leu Leu Lys Cys Asn Ala Lys Gly Ser Leu Leu Pro Glu Asn 
    850                 855                 860                 


Asn Arg Ser Asp Thr Gly Ala Glu Asp Ile Glu Arg Pro Trp Leu Tyr 
865                 870                 875                 880 


Leu Val Leu His Leu Val Pro Ile Glu Val Val Asn Arg Ile Thr Leu 
                885                 890                 895     


Gln Ile Lys Lys His Ser Val Leu Thr Asn Ser Thr Leu Asp Asp Thr 
            900                 905                 910         


Arg Ala Ala Tyr Thr Asp Ile His Gln Ala Phe Ser Leu Tyr Leu Gly 
        915                 920                 925             


Val His Gly Ala Ile Leu Gly Leu Gln Ser Leu Ser Asn Glu Pro Glu 
    930                 935                 940                 


Leu Gln Val Phe Phe Glu Lys Glu Ser Asp Phe Asn Asn Leu Phe Thr 
945                 950                 955                 960 


Asp Asn Gly Glu Gly Leu Val Pro Val Lys Gly Leu Arg Asp Ile Leu 
                965                 970                 975     


Arg Phe Gly Asn Leu Glu Gln Leu Lys Lys Met Phe Ser Asp Lys Lys 
            980                 985                 990         


Val Ala Ser Asp Asp Ile Thr Asn  Leu Lys Glu Tyr Leu  Glu Ala Thr 
        995                 1000                 1005             


Gly Gly  Lys Ser Lys Ile Ala  Arg Ala Gln Glu Lys  Arg Ile Glu 
    1010                 1015                 1020             


Leu His  Lys Thr Leu Thr Glu  Leu Pro Lys Arg Leu  Thr Lys Pro 
    1025                 1030                 1035             


Arg Val  Lys Gln Thr Gly Ile  Asp Thr Tyr Glu Lys  Asn Asn Asn 
    1040                 1045                 1050             


Ile Ser  Ile Ser Gly Ser Ile  Ser Glu Tyr Arg Lys  Asp Leu Lys 
    1055                 1060                 1065             


Cys Ile  Val Ser Tyr Arg Glu  Leu Lys Asn Lys Ile  Tyr Leu Tyr 
    1070                 1075                 1080             


Asn Val  Lys Gln Ala His Gln  Leu Ile Met Ala Thr  Gln Ala Arg 
    1085                 1090                 1095             


Leu Leu  Gly Tyr Ser Gln Ile  Arg Glu Arg Asp Leu  Tyr Phe Val 
    1100                 1105                 1110             


Leu Leu  Thr Gln Leu Met Leu  Arg Gly Val Thr Leu  Glu Lys Glu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Asp Lys Asp  Lys Leu Asn Ala Leu  Asp Thr Asp 
    1130                 1135                 1140             


Thr Val  Leu Asp Glu Glu Glu  Lys Lys Lys Leu Glu  Lys Gln Ile 
    1145                 1150                 1155             


Lys Pro  Glu Arg Ser Leu Lys  Asp Leu Val Glu Lys  Gly Leu Ile 
    1160                 1165                 1170             


Phe Leu  Ala Leu Asp Gln Leu  Ser Ser Ser Asp Lys  Asp Leu Lys 
    1175                 1180                 1185             


Ala Ile  His Ser Glu Ile Glu  Asp Met Phe Val Gly  Val Ser Pro 
    1190                 1195                 1200             


Asp Ser  Asp Asn Arg Asn Leu  Arg Asn Arg Leu Ala  His Phe Lys 
    1205                 1210                 1215             


Asp Leu  Gly Asn Lys Asn Leu  Ile Asn Ile Thr Ser  Gln Ile Asn 
    1220                 1225                 1230             


Glu Val  Arg Lys Met Met Ser  Tyr Asp Arg Lys Leu  Lys Asn Ala 
    1235                 1240                 1245             


Val Ser  Lys Ser Met Ile Asp  Leu Phe Glu Arg Tyr  Asn Leu Ile 
    1250                 1255                 1260             


Leu Ser  Phe Lys Val Gln Ser  His Lys Leu Gln Leu  Lys Asn Leu 
    1265                 1270                 1275             


Lys Ser  Lys Gln Ile Thr His  Leu Asn Asn Lys Gly  Ile Thr Glu 
    1280                 1285                 1290             


Asn Leu  Leu Ser Asp Asp Tyr  Val Ser Val Ile Lys  Arg Leu Leu 
    1295                 1300                 1305             


Leu Thr  Glu Gln Asn Pro Glu  
    1310                 1315 


<210>  1031
<211>  1182
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1031

Met Gly Ser Gly Lys Tyr Arg Ile Thr Lys Ile Ala Arg Lys Trp Asp 
1               5                   10                  15      


Lys Asn Glu Asn Trp Glu Lys Ile Ile Leu Lys Arg Ile Val Asp Asn 
            20                  25                  30          


Lys Lys Ile Lys Tyr Val Asn Glu Asn Asn Asn Lys Asp Val Asp Ile 
        35                  40                  45              


Thr Asp Thr Tyr Tyr Asn Ile Leu Ser Lys Asn Asn Ser Lys Phe Leu 
    50                  55                  60                  


Gly Ser Glu Glu Gln Phe Leu Phe Lys Val Asn Lys Met Asp Arg Asn 
65                  70                  75                  80  


Ile Lys Asn Asp Tyr Val Ile Ile Lys Asp Tyr Asn Glu Glu Glu Phe 
                85                  90                  95      


Glu Lys Phe Asp Lys Lys Ile Phe Phe Ser Arg Lys Ile Lys Val Asn 
            100                 105                 110         


Asn Glu Asp Arg Glu Lys Ile Cys Arg Asn Phe Tyr Glu Asp Glu Arg 
        115                 120                 125             


Glu Ile Met Lys Lys Arg Leu Glu Glu Ala Lys Asn Phe Asn Asn Ile 
    130                 135                 140                 


Ile Phe Asn Ile Cys Asn Lys Ile Phe Lys Leu Glu Tyr Ile Asp Tyr 
145                 150                 155                 160 


Thr Asp Glu Lys Val Tyr Glu Ile Phe Gln Lys Glu Ile Lys Phe Glu 
                165                 170                 175     


Asp Ile Lys Asn Leu Lys Glu Ala Phe Lys Gln Gln Glu Asn Gly Leu 
            180                 185                 190         


Glu Thr Asp Lys Leu Leu Ala Ile Ser Phe Asn Lys Lys Arg Asn Asn 
        195                 200                 205             


Val Leu Leu Glu Phe Ile Gln Gln Ile Thr Lys Gln Glu Phe Lys Asn 
    210                 215                 220                 


Gln Lys Glu Leu Glu Asn Trp Phe Ser His Ser Gly Glu Lys Tyr Cys 
225                 230                 235                 240 


Lys Glu Ile Phe Lys Ile Tyr Ser Asn Met Ser Gln Lys Glu Lys Tyr 
                245                 250                 255     


Ser Lys Leu Leu Gly His Arg Asn Lys Ser Ile Ala Ser Ile Ser Glu 
            260                 265                 270         


Lys Lys Glu Thr Leu Gln Arg Arg Leu Lys Leu Gly Asn Tyr Ser Asn 
        275                 280                 285             


Tyr Asp Leu Lys Lys Tyr Tyr Gln Lys Asn Tyr Lys Glu Lys Ala Ile 
    290                 295                 300                 


Lys Glu Leu Lys Asp Lys Asn Lys Glu Glu Phe Glu Lys Glu Ile Glu 
305                 310                 315                 320 


Gly Leu Ile Lys Lys Asn Tyr Lys Ile Asp Lys Leu Cys Glu Glu Ile 
                325                 330                 335     


Ser Asn Leu Glu Phe Ser Phe Ala Glu Ser Lys Lys Glu Asn Lys Asp 
            340                 345                 350         


Lys Met Ala Glu Ile Ile Val Lys Ile Lys Glu His Tyr Lys Asn Asn 
        355                 360                 365             


Val Asn Val Glu Lys Glu Leu Glu Asn Lys Glu Lys Tyr Ile Leu Ser 
    370                 375                 380                 


Met Ile His Asn Tyr Ile Lys Gly Arg Tyr Arg Lys Cys Leu Glu Leu 
385                 390                 395                 400 


Gln Gln Lys Glu Asn Val Asp Phe Glu Asn Leu Gly Lys Arg Ile Lys 
                405                 410                 415     


Glu Ile Phe Asp Ser Asn Glu Val Thr Glu Lys Leu Lys Lys Ser Ile 
            420                 425                 430         


Ile Asn Lys Val Asn Asn Tyr Lys Ile Phe Glu Thr Lys Phe Gln Asn 
        435                 440                 445             


Pro Asn Ile Glu Ser Ser Asp Asp Leu Glu Ile Leu Lys Ala Glu Glu 
    450                 455                 460                 


Thr Phe Leu Asn Lys Leu Ser Thr Ala Val Ser Lys Val Gly Tyr Thr 
465                 470                 475                 480 


Leu Asn Ile Leu Leu Asp Thr Arg Thr Thr Ser Lys Lys Met Asn Lys 
                485                 490                 495     


Lys Lys Ile Lys Asn Pro Asp Ile Leu Ala Gly Tyr Asn Val Thr Ile 
            500                 505                 510         


Glu Leu Leu Pro Tyr Cys Ser Phe Glu Ile Leu Tyr Ser Val Tyr Pro 
        515                 520                 525             


Glu Ile Lys Lys Asp Ile Glu Leu Leu Lys Gly Met Val Leu Phe Ile 
    530                 535                 540                 


Gln Glu Phe Arg Gln Lys Ile Leu His Pro Ser Gln Leu Leu Gly Ser 
545                 550                 555                 560 


Asn Val Lys Lys Ser Ile Ser Ile Lys Glu Lys Asp Thr Ile Val Lys 
                565                 570                 575     


Ile His Glu Asp Asn Lys Asp Asn Glu Lys Trp Glu Met Tyr Asn Lys 
            580                 585                 590         


Glu Lys Ile Arg Ser Tyr Phe Glu Asp Ile Leu Glu Lys Ile Pro Asp 
        595                 600                 605             


Tyr Phe Ile Glu Lys Tyr Glu Ser Asn Asn Val Phe Asn Ile Tyr Arg 
    610                 615                 620                 


Asp Phe Gly Val Lys Ile Met Glu Val Val Lys Asn Phe Asn Phe Lys 
625                 630                 635                 640 


Glu Asn Asn Ala Ile Asp Tyr Leu Phe Pro Lys Phe His Lys Ile Tyr 
                645                 650                 655     


Lys Arg Met Cys Lys Leu Glu Asn Ile Asp Asp Arg Gln Asn Gly Ala 
            660                 665                 670         


Arg Lys Tyr Leu Leu Gln Thr Ile Tyr Tyr Tyr Tyr Phe Gln Tyr Glu 
        675                 680                 685             


Ile Glu Asn Asp Lys Asn Asn Ile Ser Lys Tyr Leu Asn Leu Tyr Arg 
    690                 695                 700                 


Asn Glu Ile Lys Val Lys Lys Ile Ser Tyr Ser Tyr Ile Thr Asp Asn 
705                 710                 715                 720 


Lys Ala Val Asn Asn Lys Asn Ile Glu Ile Leu Tyr Arg Asn Ile Gln 
                725                 730                 735     


Arg Glu Gly Met Leu Asn Asn Arg Phe Ser Gln Met Asn Lys Glu Trp 
            740                 745                 750         


Ile Glu Phe Ile Val Val Gln Phe Ser Glu Phe Leu Thr Asn Lys Lys 
        755                 760                 765             


Leu Asn Trp Ile Leu Asp Asn Leu Ser Glu Tyr Lys Lys Lys Glu Lys 
    770                 775                 780                 


Leu Asp Glu Asn Asp Lys Asn Arg Leu Leu Lys Ile Leu Lys Gln Lys 
785                 790                 795                 800 


Met Asn Lys Lys Ile Thr Tyr Ser Asn Asp Ser Tyr Ala Phe Ile Ser 
                805                 810                 815     


Leu Ala Gln Phe Leu Asp Leu Lys Glu Ile Ser Asn Leu Ile His Asp 
            820                 825                 830         


Ile Lys Lys Phe Ile Gln Phe Arg Glu Lys Asn Val Ser Lys Tyr Lys 
        835                 840                 845             


Pro Glu Lys Asn Lys Leu Tyr Ile Glu Glu Leu Arg Lys Ile Leu Tyr 
    850                 855                 860                 


Ile Leu Lys Val Met Leu Glu His Lys Glu Arg Val Ile Gln Lys His 
865                 870                 875                 880 


Tyr Leu Glu Ser Tyr Asp Glu Asp Ile Ser Ile Met Tyr Gly Lys Asp 
                885                 890                 895     


Ile Glu Lys Lys Asp Ile Lys Asp Ile Glu Ile Lys Ile Lys Asn Lys 
            900                 905                 910         


Asn Gln Glu Val Ile Asn Gln Pro Leu Tyr Lys Ser Gly Asn Asp Glu 
        915                 920                 925             


Asn Ser Ser Trp Ile Val Leu Tyr Gly Ile Glu Gln Ala Lys Arg Asn 
    930                 935                 940                 


Gly Thr Phe Lys Phe Phe Glu Gly Phe Phe Asn Leu Asn Asp Asp Ile 
945                 950                 955                 960 


Lys Leu Cys Lys Glu Asn Ile Glu Lys Tyr Glu Glu Leu Tyr Asn Glu 
                965                 970                 975     


Lys Glu Glu Asn Gln Arg Lys Val Asp Glu Tyr Ile Ser Ser Glu Glu 
            980                 985                 990         


Asn Asn Asn Ile Asp Glu Val Lys  Glu Ile Lys Glu Ile  Asn Asn Asn 
        995                 1000                 1005             


Lys Gln  Leu Phe Tyr Tyr Tyr  Lys Asn Met Ile Tyr  Gly Asp Gly 
    1010                 1015                 1020             


Leu Lys  Lys Gly Tyr Asp Phe  Ile Asn Asp Ile Tyr  Ser His Tyr 
    1025                 1030                 1035             


Leu Ser  Trp Ala Tyr Arg Val  Glu Arg Asp Cys Lys  Ile Tyr Lys 
    1040                 1045                 1050             


Ile Lys  Glu Tyr Glu Asn Lys  Lys Asn Phe Asn Glu  Tyr Lys Phe 
    1055                 1060                 1065             


Lys Glu  Tyr Lys Ser Ile Lys  Asn Phe Arg Asn Glu  Val Ala His 
    1070                 1075                 1080             


Phe Asn  Tyr Phe Gln Lys Thr  Asp Lys Ser Leu Leu  Asp Leu Leu 
    1085                 1090                 1095             


Asn Asp  Phe Tyr Ser Ile Phe  Asp Tyr Asn Leu Lys  Tyr Gln Arg 
    1100                 1105                 1110             


Asp Val  Gln Lys Val Ile Asn  Asn Ile Phe Glu Lys  Tyr Gln Val 
    1115                 1120                 1125             


Ile Arg  Glu Asp Gly Gly Pro  Val Ile Phe Tyr Cys  Lys Ile Asp 
    1130                 1135                 1140             


Lys Lys  Leu Lys Leu Ser Glu  Asn Ile Ile Pro Lys  Lys His Leu 
    1145                 1150                 1155             


Lys Cys  Ser Lys Ile Lys Leu  Ile His Glu Lys Tyr  Val Glu Phe 
    1160                 1165                 1170             


Phe Arg  Lys Leu Phe Glu Tyr  Lys Lys 
    1175                 1180         


<210>  1032
<211>  1249
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1032

Met Tyr Met Lys Ile Thr Lys Ile Asp Gly Val Ser His Tyr Lys Glu 
1               5                   10                  15      


Lys Glu Lys Gly Val Leu Lys Gly Lys Asp Ile Leu Asn Gly Lys Ile 
            20                  25                  30          


Glu Lys Ile Val Lys Lys Arg Tyr Asp Ala Thr Ile Glu Ser Lys Ile 
        35                  40                  45              


Tyr Lys Glu Phe Ile Lys Leu Arg Lys Asn Arg Ile Glu Gln Asn Asn 
    50                  55                  60                  


Glu Lys Ser Ile Leu Lys Leu Ile Lys Leu Asn Ile Asp Lys Asn Glu 
65                  70                  75                  80  


Lys Glu Ile Lys Thr Leu Leu Leu Asn Lys Phe Lys Ile Lys Glu Lys 
                85                  90                  95      


Asn Lys Lys Tyr Asp Lys Tyr Met Leu Asp Glu Asn Lys Leu Asp Asn 
            100                 105                 110         


Asp Ile Lys Ile Tyr Glu Ser Val Glu Ser Leu Tyr Phe Leu Ile Lys 
        115                 120                 125             


Glu Ile Tyr Leu Gly Gln Asn Asn Lys Lys Trp Asn Ile Ser Lys Ile 
    130                 135                 140                 


Asp Leu Glu Lys Ile Met Glu Glu Asp Asn Asn Leu Ile Met Leu Gly 
145                 150                 155                 160 


Tyr Lys Leu Lys Lys Asn Ile Thr Glu Asn Asp Tyr Pro Tyr Leu Tyr 
                165                 170                 175     


Ser Asp Lys Asn Gly Gln Glu Ser Thr Ser Val Tyr Lys Leu Leu Lys 
            180                 185                 190         


Lys Leu Ile Glu Glu Asn Lys Asp Arg Asn Gln Asp Ile Arg Lys Ser 
        195                 200                 205             


Gln Glu Tyr Glu Lys Ile Arg Lys Asn Phe Glu Glu Tyr Lys Asn Arg 
    210                 215                 220                 


Lys Ile Asn Leu Leu Val Lys Ser Ile Lys Asn Asn Lys Ile Asn Ile 
225                 230                 235                 240 


Gln Tyr Ile Asn Asn Glu Ile Lys Ser His Asn Asn Ser Arg Glu Glu 
                245                 250                 255     


Asn Ile Ile Lys Phe Phe Lys Lys Met Ile Glu Glu Lys Asn Glu Pro 
            260                 265                 270         


Ile Leu Lys Asp Lys Leu Lys Leu Phe Lys Leu Glu Val Phe Phe Asp 
        275                 280                 285             


Glu Glu Phe Leu Glu Glu Ile Lys Lys Leu Leu Asp Ser Asp Asp Phe 
    290                 295                 300                 


Asp Lys Ser Tyr Asn Lys Lys Ile Ser Glu Leu Arg Gly Lys Ile Phe 
305                 310                 315                 320 


Asn Arg Ile Arg Glu Lys Ile Lys Asn Asn Lys Asn Arg Asp Glu Leu 
                325                 330                 335     


Glu Asn Ile Tyr Phe Leu Glu Leu Lys Lys Tyr Ile Glu Asn Asn Leu 
            340                 345                 350         


Ser His Lys Lys Glu Lys Asn Lys Asn Asn Asn Thr Gly Glu Glu Lys 
        355                 360                 365             


Ser Lys Glu Leu Tyr Leu Lys Phe Leu Lys Lys Val Leu Phe Ile Asp 
    370                 375                 380                 


Asp Asn Asn Arg Ile Ser Ile Glu Lys Leu Lys Ser Arg Ile Asp Asp 
385                 390                 395                 400 


Asn Phe Lys Asn Leu Leu Ile Gln His Val Ile Glu Tyr Gly Lys Ile 
                405                 410                 415     


Lys Tyr Tyr Val Glu Asn Asp Asp Tyr Ile Arg Asn Ile Val Lys Asn 
            420                 425                 430         


Gly Glu Leu Lys Leu Glu Thr Lys Asp Leu Glu Tyr Ile Lys Thr Lys 
        435                 440                 445             


Glu Thr Leu Ile Arg Lys Met Ala Val Leu Val Ser Phe Ala Ala Asn 
    450                 455                 460                 


Ser Tyr Tyr Asn Leu Phe Gly Ser Val Ser Glu Asp Ile Leu Gly Thr 
465                 470                 475                 480 


Glu Val Val Lys Asn Arg Arg Thr Asn Val Ile Lys Val Lys Ser Tyr 
                485                 490                 495     


Ile Phe Lys Glu Lys Met Leu Asn Tyr Phe Phe Asp Ser Glu Asp Phe 
            500                 505                 510         


Asp Ile Asn Lys Thr Ile Glu Val Leu Glu Ser Ile Ser Tyr Ser Ile 
        515                 520                 525             


Tyr Asn Ile Arg Asn Gly Val Gly His Phe Asn Lys Leu Val Leu Gly 
    530                 535                 540                 


Lys Tyr Lys Lys Lys Asp Ile Asn Thr Asn Lys Arg Val Glu Glu Asp 
545                 550                 555                 560 


Leu Asn Asn Asn Glu Glu Ile Lys Gly Tyr Phe Ile Gln Lys Arg Gly 
                565                 570                 575     


Glu Ile Glu Lys Lys Ile Lys Glu Arg Phe Leu Ser Asn Asn Leu Gln 
            580                 585                 590         


Tyr Tyr Tyr Ala Lys Glu Arg Ile Glu Asn Tyr Phe Glu Val Tyr Glu 
        595                 600                 605             


Phe Glu Ile Leu Lys Glu Lys Ile Pro Phe Ala Pro Asn Phe Lys Arg 
    610                 615                 620                 


Ile Ile Lys Lys Gly Glu Asp Leu Phe Asn Asn Lys Lys Asn Lys Lys 
625                 630                 635                 640 


Tyr Glu Tyr Phe Lys Asn Phe Asp Lys Asn Ser Ala Glu Glu Lys Lys 
                645                 650                 655     


Glu Phe Leu Lys Thr Arg Asn Phe Leu Leu Lys Glu Leu Tyr Tyr Asn 
            660                 665                 670         


Asn Phe Tyr Lys Glu Phe Leu Ser Lys Lys Glu Glu Leu Lys Lys Ile 
        675                 680                 685             


Val Ile Glu Val Lys Glu Glu Lys Lys Asn Arg Gly Asn Asn Lys Lys 
    690                 695                 700                 


Ser Gly Val Ser Phe Gln Asn Ile Asp Asp Tyr Asp Thr Lys Ile Asn 
705                 710                 715                 720 


Ile Ser Asp Tyr Ile Ala Ser Ile His Lys Lys Glu Met Glu Arg Val 
                725                 730                 735     


Glu Lys Tyr Asn Glu Glu Lys Gln Lys Asp Thr Ala Lys Tyr Ile Arg 
            740                 745                 750         


Asp Phe Val Glu Glu Ile Phe Leu Thr Gly Phe Ile Asn Tyr Leu Glu 
        755                 760                 765             


Lys Asp Glu Arg Leu His Phe Leu Lys Glu Glu Phe Ser Val Leu Cys 
    770                 775                 780                 


Asn Ser Asn Asn Asn Val Ile Asp Phe Asn Val Asn Ile Asn Glu Glu 
785                 790                 795                 800 


Lys Ile Lys Glu Phe Leu Lys Glu Asn Asp Ser Lys Thr Leu Asn Leu 
                805                 810                 815     


Tyr Leu Phe Phe Asn Met Ile Asp Ser Lys Arg Ile Ser Glu Phe Arg 
            820                 825                 830         


Asn Glu Leu Ile Lys Tyr Lys Gln Phe Thr Lys Lys Arg Leu Asp Glu 
        835                 840                 845             


Glu Lys Glu Phe Leu Gly Ile Lys Ile Glu Leu Tyr Glu Thr Leu Ile 
    850                 855                 860                 


Glu Phe Val Ile Leu Thr Arg Glu Lys Leu Asp Thr Lys Lys Ser Glu 
865                 870                 875                 880 


Glu Thr Asp Ala Trp Leu Val Asp Lys Leu Tyr Val Lys Glu Lys Asn 
                885                 890                 895     


Glu Cys Asn Glu Tyr Glu Tyr Lys Glu Tyr Glu Glu Ile Leu Lys Leu 
            900                 905                 910         


Phe Val Asp Glu Lys Ile Leu Ile Ser Lys Glu Ala Pro Tyr Tyr Ala 
        915                 920                 925             


Thr Asn Asn Lys Thr Pro Ile Ile Leu Ser Asn Phe Glu Lys Thr Arg 
    930                 935                 940                 


Lys Tyr Gly Thr Gln Asn Leu Leu Ala Lys Ile Gln Ser Ser Tyr Lys 
945                 950                 955                 960 


Tyr Asn Glu Ile Glu Lys Gln Lys Ile Glu Asn Tyr Asn Glu Lys Lys 
                965                 970                 975     


Glu Ser Glu Lys Lys Lys Lys Ser Asn Ile Glu Lys Leu Gln Asp Leu 
            980                 985                 990         


Lys Val Glu Leu His Lys Lys Trp  Glu Gln Asn Lys Ile  Thr Glu Lys 
        995                 1000                 1005             


Glu Ile  Lys Lys Tyr Asn Asp  Thr Ile Lys Glu Ile  Arg Glu Tyr 
    1010                 1015                 1020             


Asn Tyr  Leu Lys Asn Lys Glu  Glu Leu Gln Asn Val  Tyr Leu Leu 
    1025                 1030                 1035             


His Glu  Ile Leu Ser Asp Leu  Leu Ala Arg Asn Val  Ala Phe Phe 
    1040                 1045                 1050             


Asn Lys  Trp Glu Arg Asp Phe  Lys Phe Ile Val Ile  Ala Ile Lys 
    1055                 1060                 1065             


Gln Phe  Leu Arg Glu Asn Asp  Lys Glu Lys Val Glu  Asn Phe Leu 
    1070                 1075                 1080             


Asn Pro  Pro Asp Asn Ser Lys  Gly Lys Lys Val Tyr  Phe Ser Val 
    1085                 1090                 1095             


Ser Lys  Tyr Lys Asn Thr Val  Glu Asn Ile Asp Gly  Ile His Lys 
    1100                 1105                 1110             


Asn Phe  Met Asn Leu Ile Phe  Leu Asn Asn Lys Phe  Met Asn Arg 
    1115                 1120                 1125             


Lys Ile  Asp Lys Met Asn Cys  Thr Ile Trp Val Tyr  Phe Arg Asn 
    1130                 1135                 1140             


Tyr Ile  Ala His Phe Leu His  Leu His Thr Lys Asn  Glu Lys Ile 
    1145                 1150                 1155             


Ser Leu  Ile Asn Gln Met Asn  Leu Leu Ile Lys Leu  Phe Ser Tyr 
    1160                 1165                 1170             


Asp Lys  Lys Val Gln Asn His  Ile Leu Lys Ser Thr  Lys Thr Leu 
    1175                 1180                 1185             


Leu Glu  Lys Tyr Asn Ile Gln  Ile Asn Phe Glu Ile  Ser Asn Asp 
    1190                 1195                 1200             


Lys Asn  Glu Val Phe Lys Tyr  Lys Ile Lys Asn Arg  Leu Tyr Ser 
    1205                 1210                 1215             


Lys Lys  Gly Lys Met Leu Gly  Lys Asn Asn Lys Phe  Glu Ile Leu 
    1220                 1225                 1230             


Glu Asn  Glu Phe Leu Glu Asn  Val Lys Ala Met Leu  Glu Tyr Ser 
    1235                 1240                 1245             


Glu 
    


<210>  1033
<211>  1245
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1033

Met Lys Ile Ser Lys Val Asn His Val Lys Thr Gly Val Ser Ala Lys 
1               5                   10                  15      


Pro Ala Ile Glu Gly Gly Met Leu Tyr Asp Tyr Pro Ser Lys Glu Gly 
            20                  25                  30          


Gly Ser Lys Asp Leu Arg Lys His Ile Glu Glu Val Asn Arg Lys Ala 
        35                  40                  45              


Gln Ile Leu Tyr Asn Val Phe Asn Gln Val Lys Glu Lys Asp Lys Lys 
    50                  55                  60                  


Gln Asn Ser Val Lys Asp Ala Leu Lys Ile Ala Asn Ala Tyr Ile Asn 
65                  70                  75                  80  


Ser Thr Val Ile Phe Gly Ile Lys Lys Glu Phe Pro Glu Asn Lys Ile 
                85                  90                  95      


Cys Asn Asn Phe Ser Tyr Ala Val Asn Arg Pro Ile Arg Leu Gly Lys 
            100                 105                 110         


Glu Asn Val Phe Ile Thr Ser Ile Ser Val Ser Val Lys Glu Lys Ser 
        115                 120                 125             


Ala Lys Glu Ser Ala Glu Tyr Ile Val Asn Asn Tyr Leu Arg Asn Ser 
    130                 135                 140                 


Leu Arg Arg Asp Lys Arg Ala Ala Glu Thr Ile Val Arg Ile Leu Thr 
145                 150                 155                 160 


Ala Leu Tyr Asp Gly Lys Asn Tyr Glu Lys Leu Ile Lys Lys Ile Glu 
                165                 170                 175     


Arg Glu Asp Leu Ala Ala Val Val Ser Ala Val Ser Arg Asp Tyr Leu 
            180                 185                 190         


Lys Asp Gly Glu Leu Glu Lys Ile Ala Val Ser Ile Glu Lys Gln Lys 
        195                 200                 205             


Val Leu Val Gln Val Gly Lys Asp Gly Tyr Leu Ile Pro Ser Gly Ala 
    210                 215                 220                 


Glu His Glu Lys Lys Ala Tyr Ile Phe Asn Phe Met Lys Lys Tyr Ala 
225                 230                 235                 240 


Glu Ser Asp Glu Glu Gly Gln Arg Lys Met Leu Asn His Met Lys Asp 
                245                 250                 255     


Leu Ile Arg Leu Tyr Tyr Thr Glu Glu Glu Val Val Ser Ser Glu Ile 
            260                 265                 270         


Leu Asp Leu Ile Asn Ser Arg Asp Asn Thr Pro Phe Ser Gln Lys Asp 
        275                 280                 285             


Ile Ile Arg Ser Tyr Asn Glu Gln Ile Ala Glu Lys Val Ser Ala Phe 
    290                 295                 300                 


Leu Val Glu Arg Tyr Gln Lys Thr Leu Lys Asp Ala Lys Ser Glu Asp 
305                 310                 315                 320 


Glu Glu Gly Trp Val Arg Tyr Ile Ser Asp Lys Ala Glu Lys Leu Leu 
                325                 330                 335     


Ser Val Lys Asn Leu Thr Gln Asp Arg Ile His Cys Asp Tyr Leu Phe 
            340                 345                 350         


Lys Lys Thr Trp Glu Glu Trp Thr Ser Phe Ile Ala Lys Lys Tyr Ile 
        355                 360                 365             


Asp Leu Gly Lys Ala Thr Tyr Asn Phe Ala Met Gly Asp Ile Ser Lys 
    370                 375                 380                 


Val Ser Lys Gly Glu Ser Val Ala Phe Gly Thr Val Asn Glu Gly Phe 
385                 390                 395                 400 


Glu Thr Gly Ile Ser Ser Phe Asp Tyr Glu Arg Met Lys Ala Glu Asp 
                405                 410                 415     


Ser Leu Asn Arg Ala Met Ile Lys Tyr Ile Ser Phe Ala Val Asn Ile 
            420                 425                 430         


Phe Asp Ala Ser Val Arg Asn Pro Glu Gln Arg Thr Gly Gly Lys Glu 
        435                 440                 445             


Asp Ile Leu Leu Leu Lys Pro Glu Asn Ile Val Met Tyr Glu Asp Ala 
    450                 455                 460                 


Val Lys Arg Val Leu Arg Tyr Phe Gly Gly Ile Ser Lys Phe Ser Glu 
465                 470                 475                 480 


Ser Ser Leu Asp Val Ser Asp Lys Asn Gly Phe Phe Thr Ala Leu Lys 
                485                 490                 495     


Asp Glu Leu Tyr Ala Ala Arg Asn Tyr Ala Phe His Tyr Val Thr Gly 
            500                 505                 510         


Glu Ala Glu Lys Arg Glu Lys Pro Val Val Thr Thr Leu Leu Asp Thr 
        515                 520                 525             


Glu Tyr Met Leu Val Gly Ser Ile Phe Arg Lys Lys Tyr Phe Ser Asn 
    530                 535                 540                 


Asn Val Pro Met Phe Tyr Arg Thr Ala Asp Ile Asp Asn Leu Met Ser 
545                 550                 555                 560 


Arg Leu Tyr Lys Ser Asn Arg Val Ile Leu Ala Gln Met Pro Ser Phe 
                565                 570                 575     


Asn Lys Val Leu Ser Arg Asn Ala Val Val Asp Phe Ala Asn Ala Tyr 
            580                 585                 590         


Leu Ala Gly Asp Ser Lys Arg Glu Met Ser Gln Pro Glu Ile Ser Glu 
        595                 600                 605             


Gln Phe Arg Ser Ser Phe Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Tyr 
    610                 615                 620                 


Asp Phe Ile Leu Lys Glu Asp Leu Leu Glu Arg Phe Lys Asn Gly Val 
625                 630                 635                 640 


Glu Cys Ala Gln Ala Ser Ala Ile Lys Lys Glu Asn Asn Ser Arg Lys 
                645                 650                 655     


His Val Ala Met Lys Asn Ala Tyr Arg Asp Phe Met Ser Arg Ala Asp 
            660                 665                 670         


Lys Leu Thr Lys Thr Lys Gly Ile Thr Phe Gly Gln Phe Cys Gln Glu 
        675                 680                 685             


Ile Met Thr Glu Tyr Asn Gln Gln Asn Ser Gln Lys Gln Lys Lys Pro 
    690                 695                 700                 


Ser Ala Val Glu Lys Thr Tyr Val Val Lys Gly Gln Thr Arg Thr Ser 
705                 710                 715                 720 


Val Arg Glu Val Glu Asp Lys Glu Gln Ile Tyr Lys His Tyr Arg Thr 
                725                 730                 735     


Leu Leu Tyr Ala Gly Ile Arg Glu Ala Phe Leu Ile Tyr Leu Lys Glu 
            740                 745                 750         


Glu Ala Ala Phe Gly Phe Leu Arg Ser Pro Lys Asp Gly Arg Glu Lys 
        755                 760                 765             


Phe Arg Asp Leu Lys Glu Glu Asp Phe Ser Gln Gly Trp Thr Thr Glu 
    770                 775                 780                 


Cys Tyr Thr Lys Leu Lys Asp Ala Ile Ile Glu Asp Lys Glu Leu Ser 
785                 790                 795                 800 


Ser Trp Tyr Val Thr Ala His Phe Met Asn Gln Lys His Leu Asn His 
                805                 810                 815     


Leu Ile Gly Glu Ile Lys Asn Tyr Val Gln Phe Ile Asp Asp Ile Glu 
            820                 825                 830         


Lys Arg Ala Lys Val Thr Gly Asn Arg Val Cys Ser Thr Glu Glu Lys 
        835                 840                 845             


Met Gly Lys Phe Thr Ser Leu Leu Glu Val Leu Glu Phe Cys Lys Leu 
    850                 855                 860                 


Phe Cys Gly Gln Val Ser Asn Asn Leu Glu Asp Tyr Phe Ala Asn Asn 
865                 870                 875                 880 


Glu Glu Tyr Ala Lys Tyr Val Ala Gly Phe Val Asp Tyr Gly Gly Thr 
                885                 890                 895     


Ser Ala Ala Leu Leu Gln Ala Phe Cys Arg Glu Asn Lys Glu Leu Asn 
            900                 905                 910         


Tyr Tyr Asp Glu Leu Asn Pro Ile Pro Asn Arg Asn Ile Ile Leu Ser 
        915                 920                 925             


Leu Leu Tyr Gly Asn Thr Ala Val Leu Ser Ser Ser Met Lys Lys Val 
    930                 935                 940                 


Thr Leu Gln Glu Val Lys Gly Tyr Gln Lys Asn Lys Glu Ser Leu Ser 
945                 950                 955                 960 


Gly Val Phe Lys Asn Gly Ala Cys Lys Asp Glu Asn Glu Gln Arg Lys 
                965                 970                 975     


Met Ser Asn Tyr Gln Lys Gln Lys Asn Arg Ile Glu Phe Val Asp Val 
            980                 985                 990         


Leu Thr Leu Thr Glu Leu Leu Asn  Asp Leu Tyr Gly Gln  Leu Ile Ser 
        995                 1000                 1005             


Tyr Ser  Tyr Leu Arg Glu Arg  Asp Leu Met Phe Met  Gln Leu Gly 
    1010                 1015                 1020             


Phe Tyr  Tyr Thr Lys Leu Phe  His Thr Ser Ser Val  Pro Ala Gln 
    1025                 1030                 1035             


Asp Lys  Leu Arg Val Leu Ser  Gly Asp Cys Asp Ile  Lys Asp Gly 
    1040                 1045                 1050             


Ala Val  Leu Tyr Gln Ile Ala  Ala Met Tyr Ser Tyr  Asp Leu Pro 
    1055                 1060                 1065             


Ile Tyr  Gly Ile Ser Lys Gln  Gly Val Ala Val Arg  Lys Lys Ser 
    1070                 1075                 1080             


Gly Val  Ser Thr Gly Ala Lys  Leu Asn Gln Phe Ser  Thr Glu Tyr 
    1085                 1090                 1095             


Cys Gly  Gly Lys Trp Asp Ile  Tyr Thr Asn Gly Leu  Tyr Phe Phe 
    1100                 1105                 1110             


Glu Asp  Val Asp Gly Arg His  Lys Asp Tyr Val Glu  Val Arg Asn 
    1115                 1120                 1125             


Tyr Ile  Glu His Phe Lys Tyr  Phe Ala Asp His Lys  Lys Ser Ile 
    1130                 1135                 1140             


Leu Asp  Leu Tyr Ser Asp Leu  Tyr Asn Gly Phe Phe  Ser Tyr Asp 
    1145                 1150                 1155             


Thr Lys  Leu Lys Lys Ser Met  Ser Phe Val Leu Pro  Asn Ile Leu 
    1160                 1165                 1170             


Leu Ser  His Phe Val Asn Ala  Lys Leu Ser Tyr Glu  Lys Asp Val 
    1175                 1180                 1185             


Val Gln  Lys Asn Ser Glu Ser  Tyr Arg Arg Ala Arg  Ile Val Ile 
    1190                 1195                 1200             


Arg Glu  Lys Asp Ile Lys Ser  Asp Phe Leu Thr Tyr  Lys Asn Lys 
    1205                 1210                 1215             


Glu Asn  Ser Lys Ala Phe Tyr  Val Pro Ala Arg Asn  Asp Val Phe 
    1220                 1225                 1230             


Leu Lys  Glu Val Leu Asp Met  Ile Ser Phe Lys Arg  
    1235                 1240                 1245 


<210>  1034
<211>  1254
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1034

Met Glu Gly Glu Gly Val Met Lys Leu Thr Arg Arg Arg Ile Gly Gln 
1               5                   10                  15      


Glu Arg Lys Gly Glu Lys Ile Lys Ala Ala Phe Tyr Arg Asn Ile Ser 
            20                  25                  30          


Arg Gly Leu Leu Tyr Leu Asp Ser Glu Asn Cys Asp Tyr Thr Glu Cys 
        35                  40                  45              


Val Val Glu Ala Met Asp Phe Glu Arg Ser Cys Arg Gly Arg Ile Leu 
    50                  55                  60                  


Lys Asn Ala Asp Asn Glu Lys Asn Pro Phe Tyr Lys Ile Val Lys Gly 
65                  70                  75                  80  


Leu Thr Asp Lys Asp Thr Gly Ile Phe Tyr Glu Ala Ile Val Asp Asp 
                85                  90                  95      


Gly Asn Asp Ile Asp Ile Leu Ile Asn Asn Asn Ile Thr Arg Tyr Gly 
            100                 105                 110         


Lys Glu Leu Gln Ala Pro Gly Ser Thr Val Ser Phe Glu Glu Leu Ile 
        115                 120                 125             


Arg Glu Ile Gln Ser Gly Thr Ser Lys Ser Glu Ile Ile Leu Glu Leu 
    130                 135                 140                 


Glu Lys Ile Lys Arg Met Ile Gln Asp Asp Ile Gln Lys Ser Lys Asp 
145                 150                 155                 160 


Arg Leu Ile Lys Ser Ile Ala Asn Asn Arg Ile Pro Phe Ser Leu Gln 
                165                 170                 175     


Ser Asn Gly Leu Val Pro Ser Ser Lys Lys Met Lys Trp Leu Tyr Lys 
            180                 185                 190         


Ile Leu Asp Asp Asn Asn Ile Leu Lys Lys Tyr Trp Asp Lys Tyr Glu 
        195                 200                 205             


Tyr Glu Lys Leu Glu Ser Thr Leu Ile Lys Ala Ile Glu Asp Leu Gln 
    210                 215                 220                 


Tyr Lys Asn Ala Arg Leu Ile Ser Arg Thr Val Ser Gly Ala Ile Arg 
225                 230                 235                 240 


Asp Tyr His Arg Ser Leu Lys Thr Arg Tyr Thr Asn Ser Ser Leu Glu 
                245                 250                 255     


Gly Lys Ala Arg Ser Glu His Glu Ile Asn Ser Thr Glu Asn Asn Ser 
            260                 265                 270         


Glu Lys Glu Glu Phe Leu Leu Phe Leu Lys Ala Val Glu Gln His Phe 
        275                 280                 285             


Lys Lys Tyr Phe Pro Val Lys Gly Lys His Ser Thr Asp Ala Tyr Asp 
    290                 295                 300                 


Lys Ala Leu Cys Gln Ala Glu Asn Tyr Lys Leu Tyr Cys Lys Phe Asn 
305                 310                 315                 320 


Phe Val Lys Lys Glu Val Asn Arg Ser Ile Met Asn Gln Leu Val Ser 
                325                 330                 335     


Gly Leu Ile Gln His Gly Lys Leu Ile His Tyr Phe Asn Asn Asp Gly 
            340                 345                 350         


Thr Trp Asp Val Asp Phe Leu Asn Ser His Gly Leu Ser Tyr Ile Gln 
        355                 360                 365             


Val Glu Glu Ala Phe Lys Lys Ser Leu Met Ala Ser Leu Ser Trp Gly 
    370                 375                 380                 


Ile Asn Arg Leu Thr Ser Phe Tyr Tyr Asp Ile Asn Asp Thr Arg Ile 
385                 390                 395                 400 


Asn Ser Asn Glu Glu Ser Ile Val Asp Asp Ile Leu Leu Glu Ser Lys 
                405                 410                 415     


Arg His Lys Glu Leu Arg Arg Asn Tyr Tyr Asn Asp Leu Arg Ser Asn 
            420                 425                 430         


Asp Ile Lys Gln Lys Tyr Phe Arg Glu Lys Leu Ala Ala Cys Tyr Ser 
        435                 440                 445             


Ile Ile Ala Lys Asp Asp Lys Asp Lys Ile Ser Asp Asp Ile Asn Lys 
    450                 455                 460                 


Leu Ile Gly Leu Val Glu Arg Ile Arg Lys Ser Val Ala His Ile Arg 
465                 470                 475                 480 


His Ser Ser Phe His Tyr Lys Lys Val Thr Leu Pro Glu Met Leu Asn 
                485                 490                 495     


Ala Val Asn Ile Asn Tyr Ile Arg Val Glu Glu Phe Phe Ala Arg Asp 
            500                 505                 510         


Ile Glu Asn Leu Tyr Asn Ala Phe Arg Glu Lys Ile Arg Ser Leu Gly 
        515                 520                 525             


Ile Val Glu Tyr Tyr Ser Gly Ser Asp Ile Ala Glu Cys Phe Glu Lys 
    530                 535                 540                 


Cys Gly Ile Lys Phe Thr Leu Tyr Ser Pro Gln Asn Ser Leu Ile Pro 
545                 550                 555                 560 


Ser Phe Lys Lys Ile Tyr Lys Lys Gly Val Asn Leu Asn Lys Gly Tyr 
                565                 570                 575     


Arg Ala Lys Glu Asn Gln Lys Glu Pro Asn Lys His Asn Lys His Asp 
            580                 585                 590         


Glu Gln Val Asn Arg Lys Asp Leu Leu Trp Tyr Leu Glu Ile Pro Asn 
        595                 600                 605             


Asn Glu Gln Gly Leu Leu Ala Tyr Lys Asn Leu Leu Gln Ile Ile Tyr 
    610                 615                 620                 


Tyr His Ser Phe Leu Pro Glu Val Gln Lys Asn Glu Leu Leu Ile Thr 
625                 630                 635                 640 


Asn Phe Ile Asn Asn Thr Lys Glu Trp Asn Arg Val Glu Ala Lys Lys 
                645                 650                 655     


Ile Ser Glu Arg Arg Gly Lys Lys Asn Lys Ser Ser Lys His Asn Asn 
            660                 665                 670         


Glu Lys Asp Phe Lys Ala Tyr Arg Tyr Glu Ala Ile Pro Asp Tyr Gln 
        675                 680                 685             


Gly Glu Ser Leu Asp Asp Tyr Leu Lys Ile Ile Gln Arg Glu Gln Met 
    690                 695                 700                 


Ala Gln Ala Asn Glu Met Asp Glu Gly Thr Thr Asp His Asn Tyr Tyr 
705                 710                 715                 720 


Ile Arg Phe Met Gln Asp Val Val Val Trp Ala Phe Gly Asp Tyr Leu 
                725                 730                 735     


Glu Lys Leu Met Gly Arg Tyr Arg Asp Phe Leu Gln Lys Pro Ala Leu 
            740                 745                 750         


Gln Asp Val Asp Ile Tyr Asp Ala Leu Glu Glu Leu Leu Pro Glu Asp 
        755                 760                 765             


Lys Glu Lys Gly Lys Phe Pro Met Ala Cys Arg Phe Asn Met Lys Thr 
    770                 775                 780                 


Asp Glu Asn Gly Asn Thr Ile Val Tyr Thr Phe Glu Gln Ile Lys Asp 
785                 790                 795                 800 


Gln Ile Lys Asn Arg Lys Asp Leu Leu Cys Phe Tyr Leu Phe Leu Arg 
                805                 810                 815     


Leu Leu Asp Ala Arg Glu Ile Ala Lys Leu Gln His Gln Phe Ile Arg 
            820                 825                 830         


Tyr Arg Cys Ser Leu Ile Glu Arg Arg Leu Pro Asp Gly Arg Ser Asn 
        835                 840                 845             


Gln Ile Glu Asp Glu Ile Glu Leu Phe Lys Glu Leu Glu Glu Leu Met 
    850                 855                 860                 


Glu Leu Val Arg Tyr Thr Ile Pro Glu Val His Ser Leu Tyr Gly Lys 
865                 870                 875                 880 


Lys Lys Ser Val Phe Asn Val Met Ile Gln Leu His Phe Lys Glu Phe 
                885                 890                 895     


Phe Glu Val Lys Ala Leu Lys Asn Pro Glu Val Val Asn Leu Tyr Tyr 
            900                 905                 910         


Gln Leu Asp Lys Lys Thr Pro Ile Pro Arg Lys His Met Ala Leu Leu 
        915                 920                 925             


Ile Arg Ser Val Pro Leu Pro Leu Tyr Lys Asn Met Phe Lys Asn Tyr 
    930                 935                 940                 


Tyr Cys Ile Thr Glu Asn Asp Phe Lys Glu Tyr Ile Gln Thr Ser Glu 
945                 950                 955                 960 


Val Ile Glu Glu Ile Gln Asn Lys Gln Lys Glu Leu His Lys Met Leu 
                965                 970                 975     


Glu Arg Ala Arg Leu Lys Ser Pro Asn Ile Glu Lys Met Lys Asp Lys 
            980                 985                 990         


Asn Leu Trp Tyr Ile Glu Asp Lys  Asn Val Val Glu Lys  Val Ile Glu 
        995                 1000                 1005             


Tyr Glu  Glu Asn Leu Arg Ile  Ile Ala Arg Tyr Asn  Gln Ile Lys 
    1010                 1015                 1020             


Arg Lys  Ile Thr Phe Glu Ser  Leu Tyr Arg Ile Phe  Gln Ile His 
    1025                 1030                 1035             


Val Asp  Leu Cys Ala Arg Leu  Ile Gly Tyr Thr Gln  Asp Trp Glu 
    1040                 1045                 1050             


Arg Asp  Met Tyr Phe Leu Leu  Lys Ser Leu Glu Asn  Lys Gly Ile 
    1055                 1060                 1065             


Ile Arg  Asn Asn Ile Leu Asp  Arg Ile Phe Ser Arg  Asn Ile Val 
    1070                 1075                 1080             


Arg Glu  Leu Asn Asn Ile Leu  Asn Thr Asn Glu Lys  Gly Ile Leu 
    1085                 1090                 1095             


Tyr Lys  Leu Cys Trp His Lys  Glu Leu Thr Ile Asp  Asp Met Tyr 
    1100                 1105                 1110             


Asn Lys  Met Asp Ile Arg Asn  Ser Ile Ala His Leu  Asn His Phe 
    1115                 1120                 1125             


Thr Gln  Ser Trp Asn Phe Asp  Lys Pro Ser Leu Ile  Glu Met Ile 
    1130                 1135                 1140             


Asn Ala  Leu Arg Val Leu Leu  His Tyr Asp Arg Lys  Arg Gln Asn 
    1145                 1150                 1155             


Ala Val  Leu Lys Thr Ile Asn  Asp Leu Leu Leu Lys  Asp Tyr Arg 
    1160                 1165                 1170             


Ile Lys  Ile Glu Trp Glu Arg  Lys Val His Asp Thr  Gly Glu Ile 
    1175                 1180                 1185             


Lys Phe  Asp Ile Asn Gly Asp  Val Ile Asn Glu Pro  Ile Ile His 
    1190                 1195                 1200             


Leu Lys  Asn Ile His Lys Gly  Ala Lys Cys Lys Val  Tyr Asn Lys 
    1205                 1210                 1215             


Ala Tyr  Met Ile Glu Lys Gln  Arg Glu Trp Leu Cys  Asn Gly Ile 
    1220                 1225                 1230             


Arg Glu  Glu Ile Tyr Asp Lys  Asn Phe Leu Glu Cys  Ile Glu Arg 
    1235                 1240                 1245             


Leu Phe  Lys Phe Asn Tyr 
    1250                 


<210>  1035
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1035

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  1036
<211>  1245
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1036

Met Lys Ile Ser Lys Val Asn His Val Lys Thr Gly Val Ser Ala Lys 
1               5                   10                  15      


Pro Ala Ile Glu Gly Gly Met Leu Tyr Asp Tyr Pro Ser Lys Glu Gly 
            20                  25                  30          


Gly Ser Lys Asp Leu Arg Lys His Ile Glu Glu Val Asn Arg Lys Ala 
        35                  40                  45              


Gln Ile Leu Tyr Asn Val Phe Asn Gln Val Lys Glu Lys Asp Lys Lys 
    50                  55                  60                  


Gln Asn Ser Val Lys Asp Ala Leu Lys Ile Ala Asn Ala Tyr Ile Asn 
65                  70                  75                  80  


Ser Thr Val Ile Phe Gly Ile Lys Lys Glu Phe Pro Glu Asn Lys Ile 
                85                  90                  95      


Cys Asn Asn Phe Ser Tyr Ala Val Asn Arg Pro Ile Arg Leu Gly Lys 
            100                 105                 110         


Glu Asn Val Phe Ile Thr Ser Ile Ser Val Ser Val Lys Glu Lys Ser 
        115                 120                 125             


Ala Lys Glu Ser Ala Glu Tyr Ile Val Asn Asn Tyr Leu Arg Asn Ser 
    130                 135                 140                 


Leu Arg Arg Asp Lys Arg Ala Ala Glu Thr Ile Val Arg Ile Leu Thr 
145                 150                 155                 160 


Ala Leu Tyr Asp Gly Lys Asn Tyr Glu Lys Leu Ile Lys Lys Ile Glu 
                165                 170                 175     


Arg Glu Asp Leu Ala Ala Val Val Ser Ala Val Ser Arg Asp Tyr Leu 
            180                 185                 190         


Lys Asp Gly Glu Leu Glu Lys Ile Ala Val Ser Ile Glu Lys Gln Lys 
        195                 200                 205             


Val Leu Val Gln Val Gly Lys Asp Gly Tyr Leu Ile Pro Ser Gly Ala 
    210                 215                 220                 


Glu His Glu Lys Lys Ala Tyr Ile Phe Asn Phe Met Lys Lys Tyr Ala 
225                 230                 235                 240 


Glu Ser Asp Glu Glu Gly Gln Arg Lys Met Leu Asn His Met Lys Asp 
                245                 250                 255     


Leu Ile Arg Leu Tyr Tyr Thr Glu Glu Glu Val Val Ser Ser Glu Ile 
            260                 265                 270         


Leu Asp Leu Ile Asn Ser Arg Asp Asn Thr Pro Phe Ser Gln Lys Asp 
        275                 280                 285             


Ile Ile Arg Ser Tyr Asn Glu Gln Ile Ala Glu Lys Val Ser Ala Phe 
    290                 295                 300                 


Leu Val Glu Arg Tyr Gln Lys Thr Leu Lys Asp Ala Lys Ser Glu Asp 
305                 310                 315                 320 


Glu Glu Gly Trp Val Arg Tyr Ile Ser Asp Lys Ala Glu Lys Leu Leu 
                325                 330                 335     


Ser Val Lys Asn Leu Thr Gln Asp Arg Ile His Cys Asp Tyr Leu Phe 
            340                 345                 350         


Lys Lys Thr Trp Glu Glu Trp Thr Ser Phe Ile Ala Lys Lys Tyr Ile 
        355                 360                 365             


Asp Leu Gly Lys Ala Thr Tyr Asn Phe Ala Met Gly Asp Ile Ser Lys 
    370                 375                 380                 


Val Ser Lys Gly Glu Ser Val Ala Phe Gly Thr Val Asn Glu Gly Phe 
385                 390                 395                 400 


Glu Thr Gly Ile Ser Ser Phe Asp Tyr Glu Arg Met Lys Ala Glu Asp 
                405                 410                 415     


Ser Leu Asn Arg Ala Met Ile Lys Tyr Ile Ser Phe Ala Val Asn Ile 
            420                 425                 430         


Phe Asp Ala Ser Val Arg Asn Pro Glu Gln Arg Thr Gly Gly Lys Glu 
        435                 440                 445             


Asp Ile Leu Leu Leu Lys Pro Glu Asn Ile Val Met Tyr Glu Asp Ala 
    450                 455                 460                 


Val Lys Arg Val Leu Arg Tyr Phe Gly Gly Ile Ser Lys Phe Ser Glu 
465                 470                 475                 480 


Ser Ser Leu Asp Val Ser Asp Lys Asn Gly Phe Phe Thr Ala Leu Lys 
                485                 490                 495     


Asp Glu Leu Tyr Ala Ala Arg Asn Tyr Ala Phe His Tyr Val Thr Gly 
            500                 505                 510         


Glu Ala Glu Lys Arg Glu Lys Pro Val Val Thr Thr Leu Leu Asp Thr 
        515                 520                 525             


Glu Tyr Met Leu Val Gly Ser Ile Phe Arg Lys Lys Tyr Phe Ser Asn 
    530                 535                 540                 


Asn Val Pro Met Phe Tyr Arg Thr Ala Asp Ile Asp Asn Leu Met Ser 
545                 550                 555                 560 


Arg Leu Tyr Lys Ser Asn Arg Val Ile Leu Ala Gln Met Pro Ser Phe 
                565                 570                 575     


Asn Lys Val Leu Ser Arg Asn Ala Val Val Asp Phe Ala Asn Ala Tyr 
            580                 585                 590         


Leu Ala Gly Asp Ser Lys Arg Glu Met Ser Gln Pro Glu Ile Ser Glu 
        595                 600                 605             


Gln Phe Arg Ser Ser Phe Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Tyr 
    610                 615                 620                 


Asp Phe Ile Leu Lys Glu Asp Leu Leu Glu Arg Phe Lys Asn Gly Val 
625                 630                 635                 640 


Glu Cys Ala Gln Ala Ser Ala Ile Lys Lys Glu Asn Asn Ser Arg Lys 
                645                 650                 655     


His Val Ala Met Lys Asn Ala Tyr Arg Asp Phe Met Ser Arg Ala Asp 
            660                 665                 670         


Lys Leu Thr Lys Thr Lys Gly Ile Thr Phe Gly Gln Phe Cys Gln Glu 
        675                 680                 685             


Ile Met Thr Glu Tyr Asn Gln Gln Asn Ser Gln Lys Gln Lys Lys Pro 
    690                 695                 700                 


Ser Ala Val Glu Lys Thr Tyr Val Val Lys Gly Gln Thr Arg Thr Ser 
705                 710                 715                 720 


Val Arg Glu Val Glu Asp Lys Glu Gln Ile Tyr Lys His Tyr Arg Thr 
                725                 730                 735     


Leu Leu Tyr Ala Gly Ile Arg Glu Ala Phe Leu Ile Tyr Leu Lys Glu 
            740                 745                 750         


Glu Ala Ala Phe Gly Phe Leu Arg Ser Pro Lys Asp Gly Arg Glu Lys 
        755                 760                 765             


Phe Arg Asp Leu Lys Glu Glu Asp Phe Ser Gln Gly Trp Thr Thr Glu 
    770                 775                 780                 


Cys Tyr Thr Lys Leu Lys Asp Ala Ile Ile Glu Asp Lys Glu Leu Ser 
785                 790                 795                 800 


Ser Trp Tyr Val Thr Ala His Phe Met Asn Gln Lys His Leu Asn His 
                805                 810                 815     


Leu Ile Gly Glu Ile Lys Asn Tyr Val Gln Phe Ile Asp Asp Ile Glu 
            820                 825                 830         


Lys Arg Ala Lys Val Thr Gly Asn Arg Val Cys Ser Thr Glu Glu Lys 
        835                 840                 845             


Met Gly Lys Phe Thr Ser Leu Leu Glu Val Leu Glu Phe Cys Lys Leu 
    850                 855                 860                 


Phe Cys Gly Gln Val Ser Asn Asn Leu Glu Asp Tyr Phe Ala Asn Asn 
865                 870                 875                 880 


Glu Glu Tyr Ala Lys Tyr Val Ala Gly Phe Val Asp Tyr Gly Gly Thr 
                885                 890                 895     


Ser Ala Ala Leu Leu Gln Ala Phe Cys Arg Glu Asn Lys Glu Leu Asn 
            900                 905                 910         


Tyr Tyr Asp Glu Leu Asn Pro Ile Pro Asn Arg Asn Ile Ile Leu Ser 
        915                 920                 925             


Leu Leu Tyr Gly Asn Thr Ala Val Leu Ser Ser Ser Met Lys Lys Val 
    930                 935                 940                 


Thr Leu Gln Glu Val Lys Gly Tyr Gln Lys Asn Lys Glu Ser Leu Ser 
945                 950                 955                 960 


Gly Val Phe Lys Asn Gly Ala Cys Lys Asp Glu Asn Glu Gln Arg Lys 
                965                 970                 975     


Met Ser Asn Tyr Gln Lys Gln Lys Asn Arg Ile Glu Phe Val Asp Val 
            980                 985                 990         


Leu Thr Leu Thr Glu Leu Leu Asn  Asp Leu Tyr Gly Gln  Leu Ile Ser 
        995                 1000                 1005             


Tyr Ser  Tyr Leu Arg Glu Arg  Asp Leu Met Phe Met  Gln Leu Gly 
    1010                 1015                 1020             


Phe Tyr  Tyr Thr Lys Leu Phe  His Thr Ser Ser Val  Pro Ala Gln 
    1025                 1030                 1035             


Asp Lys  Leu Arg Val Leu Ser  Gly Asp Cys Asp Ile  Lys Asp Gly 
    1040                 1045                 1050             


Ala Val  Leu Tyr Gln Ile Ala  Ala Met Tyr Ser Tyr  Asp Leu Pro 
    1055                 1060                 1065             


Ile Tyr  Gly Ile Ser Lys Gln  Gly Val Ala Val Arg  Lys Lys Ser 
    1070                 1075                 1080             


Gly Val  Ser Thr Gly Ala Lys  Leu Asn Gln Phe Ser  Thr Glu Tyr 
    1085                 1090                 1095             


Cys Gly  Gly Lys Trp Asp Ile  Tyr Thr Asn Gly Leu  Tyr Phe Phe 
    1100                 1105                 1110             


Glu Asp  Val Asp Gly Arg His  Lys Asp Tyr Val Glu  Val Arg Asn 
    1115                 1120                 1125             


Tyr Ile  Glu His Phe Lys Tyr  Phe Ala Asp His Lys  Lys Ser Ile 
    1130                 1135                 1140             


Leu Asp  Leu Tyr Ser Asp Leu  Tyr Asn Gly Phe Phe  Ser Tyr Asp 
    1145                 1150                 1155             


Thr Lys  Leu Lys Lys Ser Met  Ser Phe Val Leu Pro  Asn Ile Leu 
    1160                 1165                 1170             


Leu Ser  His Phe Val Asn Ala  Lys Leu Ser Tyr Glu  Lys Asp Val 
    1175                 1180                 1185             


Val Gln  Lys Asn Ser Glu Ser  Tyr Arg Arg Ala Arg  Ile Val Ile 
    1190                 1195                 1200             


Arg Glu  Lys Asp Ile Lys Ser  Asp Phe Leu Thr Tyr  Lys Asn Lys 
    1205                 1210                 1215             


Glu Asn  Ser Lys Ala Phe Tyr  Val Pro Ala Arg Asn  Asp Val Phe 
    1220                 1225                 1230             


Leu Lys  Glu Val Leu Asp Met  Ile Ser Phe Lys Arg  
    1235                 1240                 1245 


<210>  1037
<211>  1245
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1037

Met Lys Ile Ser Lys Val Asn His Val Lys Thr Gly Val Ser Ala Lys 
1               5                   10                  15      


Pro Ala Ile Glu Gly Gly Met Leu Tyr Asp Tyr Pro Ser Lys Glu Gly 
            20                  25                  30          


Gly Ser Lys Asp Leu Arg Lys His Ile Glu Glu Val Asn Arg Lys Ala 
        35                  40                  45              


Gln Ile Leu Tyr Asn Val Phe Asn Gln Val Lys Glu Lys Asp Lys Lys 
    50                  55                  60                  


Gln Asn Ser Val Lys Asp Ala Leu Lys Ile Ala Asn Ala Tyr Ile Asn 
65                  70                  75                  80  


Ser Thr Val Ile Phe Gly Ile Lys Lys Glu Phe Pro Glu Asn Lys Ile 
                85                  90                  95      


Cys Asn Asn Phe Ser Tyr Ala Val Asn Arg Pro Ile Arg Leu Gly Lys 
            100                 105                 110         


Glu Asn Val Phe Ile Thr Ser Ile Ser Val Ser Val Lys Glu Lys Ser 
        115                 120                 125             


Ala Lys Glu Ser Ala Glu Tyr Ile Val Asn Asn Tyr Leu Arg Asn Ser 
    130                 135                 140                 


Leu Arg Arg Asp Lys Arg Ala Ala Glu Thr Ile Val Arg Ile Leu Thr 
145                 150                 155                 160 


Ala Leu Tyr Asp Gly Lys Asn Tyr Glu Lys Leu Ile Lys Lys Ile Glu 
                165                 170                 175     


Arg Glu Asp Leu Ala Ala Val Val Ser Ala Val Ser Arg Asp Tyr Leu 
            180                 185                 190         


Lys Asp Gly Glu Leu Glu Lys Ile Ala Val Ser Ile Glu Lys Gln Lys 
        195                 200                 205             


Val Leu Val Gln Val Gly Lys Asp Gly Tyr Leu Ile Pro Ser Gly Ala 
    210                 215                 220                 


Glu His Glu Lys Lys Ala Tyr Ile Phe Asn Phe Met Lys Lys Tyr Ala 
225                 230                 235                 240 


Glu Ser Asp Glu Glu Gly Gln Arg Lys Met Leu Asn His Met Lys Asp 
                245                 250                 255     


Leu Ile Arg Leu Tyr Tyr Thr Glu Glu Glu Val Val Ser Ser Glu Ile 
            260                 265                 270         


Leu Asp Leu Ile Asn Ser Arg Asp Asn Thr Pro Phe Ser Gln Lys Asp 
        275                 280                 285             


Ile Ile Arg Ser Tyr Asn Glu Gln Ile Ala Glu Lys Val Ser Ala Phe 
    290                 295                 300                 


Leu Val Glu Arg Tyr Gln Lys Thr Leu Lys Asp Ala Lys Ser Glu Asp 
305                 310                 315                 320 


Glu Glu Gly Trp Val Arg Tyr Ile Ser Asp Lys Ala Glu Lys Leu Leu 
                325                 330                 335     


Ser Val Lys Asn Leu Thr Gln Asp Arg Ile His Cys Asp Tyr Leu Phe 
            340                 345                 350         


Lys Lys Thr Trp Glu Glu Trp Thr Ser Phe Ile Ala Lys Lys Tyr Ile 
        355                 360                 365             


Asp Leu Gly Lys Ala Thr Tyr Asn Phe Ala Met Gly Asp Ile Ser Lys 
    370                 375                 380                 


Val Ser Lys Gly Glu Ser Val Ala Phe Gly Thr Val Asn Glu Gly Phe 
385                 390                 395                 400 


Glu Thr Gly Ile Ser Ser Phe Asp Tyr Glu Arg Met Lys Ala Glu Asp 
                405                 410                 415     


Ser Leu Asn Arg Ala Met Ile Lys Tyr Ile Ser Phe Ala Val Asn Ile 
            420                 425                 430         


Phe Asp Ala Ser Val Arg Asn Pro Glu Gln Arg Thr Gly Gly Lys Glu 
        435                 440                 445             


Asp Ile Leu Leu Leu Lys Pro Glu Asn Ile Val Met Tyr Glu Asp Ala 
    450                 455                 460                 


Val Lys Arg Val Leu Arg Tyr Phe Gly Gly Ile Ser Lys Phe Ser Glu 
465                 470                 475                 480 


Ser Ser Leu Asp Val Ser Asp Lys Asn Gly Phe Phe Thr Ala Leu Lys 
                485                 490                 495     


Asp Glu Leu Tyr Ala Ala Arg Asn Tyr Ala Phe His Tyr Val Thr Gly 
            500                 505                 510         


Glu Ala Glu Lys Arg Glu Lys Pro Val Val Thr Thr Leu Leu Asp Thr 
        515                 520                 525             


Glu Tyr Met Leu Val Gly Ser Ile Phe Arg Lys Lys Tyr Phe Ser Asn 
    530                 535                 540                 


Asn Val Pro Met Phe Tyr Arg Thr Ala Asp Ile Asp Asn Leu Met Ser 
545                 550                 555                 560 


Arg Leu Tyr Lys Ser Asn Arg Val Ile Leu Ala Gln Met Pro Ser Phe 
                565                 570                 575     


Asn Lys Val Leu Ser Arg Asn Ala Val Val Asp Phe Ala Asn Ala Tyr 
            580                 585                 590         


Leu Ala Gly Asp Ser Lys Arg Glu Met Ser Gln Pro Glu Ile Ser Glu 
        595                 600                 605             


Gln Phe Arg Ser Ser Phe Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Tyr 
    610                 615                 620                 


Asp Phe Ile Leu Lys Glu Asp Leu Leu Glu Arg Phe Lys Asn Gly Val 
625                 630                 635                 640 


Glu Cys Ala Gln Ala Ser Ala Ile Lys Lys Glu Asn Asn Ser Arg Lys 
                645                 650                 655     


His Val Ala Met Lys Asn Ala Tyr Arg Asp Phe Met Ser Arg Ala Asp 
            660                 665                 670         


Lys Leu Thr Lys Thr Lys Gly Ile Thr Phe Gly Gln Phe Cys Gln Glu 
        675                 680                 685             


Ile Met Thr Glu Tyr Asn Gln Gln Asn Ser Gln Lys Gln Lys Lys Pro 
    690                 695                 700                 


Ser Ala Val Glu Lys Thr Tyr Val Val Lys Gly Gln Thr Arg Thr Ser 
705                 710                 715                 720 


Val Arg Glu Val Glu Asp Lys Glu Gln Ile Tyr Lys His Tyr Arg Thr 
                725                 730                 735     


Leu Leu Tyr Ala Gly Ile Arg Glu Ala Phe Leu Ile Tyr Leu Lys Glu 
            740                 745                 750         


Glu Ala Ala Phe Gly Phe Leu Arg Ser Pro Lys Asp Gly Arg Glu Lys 
        755                 760                 765             


Phe Arg Asp Leu Lys Glu Glu Asp Phe Ser Gln Gly Trp Thr Thr Glu 
    770                 775                 780                 


Cys Tyr Thr Lys Leu Lys Asp Ala Ile Ile Glu Asp Lys Glu Leu Ser 
785                 790                 795                 800 


Ser Trp Tyr Val Thr Ala His Phe Met Asn Gln Lys His Leu Asn His 
                805                 810                 815     


Leu Ile Gly Glu Ile Lys Asn Tyr Val Gln Phe Ile Asp Asp Ile Glu 
            820                 825                 830         


Lys Arg Ala Lys Val Thr Gly Asn Arg Val Cys Ser Thr Glu Glu Lys 
        835                 840                 845             


Met Gly Lys Phe Thr Ser Leu Leu Glu Val Leu Glu Phe Cys Lys Leu 
    850                 855                 860                 


Phe Cys Gly Gln Val Ser Asn Asn Leu Glu Asp Tyr Phe Ala Asn Asn 
865                 870                 875                 880 


Glu Glu Tyr Ala Lys Tyr Val Ala Gly Phe Val Asp Tyr Gly Gly Thr 
                885                 890                 895     


Ser Ala Ala Leu Leu Gln Ala Phe Cys Arg Glu Asn Lys Glu Leu Asn 
            900                 905                 910         


Tyr Tyr Asp Glu Leu Asn Pro Ile Pro Asn Arg Asn Ile Ile Leu Ser 
        915                 920                 925             


Leu Leu Tyr Gly Asn Thr Ala Val Leu Ser Ser Ser Met Lys Lys Val 
    930                 935                 940                 


Thr Leu Gln Glu Val Lys Gly Tyr Gln Lys Asn Lys Glu Ser Leu Ser 
945                 950                 955                 960 


Gly Val Phe Lys Asn Gly Ala Cys Lys Asp Glu Asn Glu Gln Arg Lys 
                965                 970                 975     


Met Ser Asn Tyr Gln Lys Gln Lys Asn Arg Ile Glu Phe Val Asp Val 
            980                 985                 990         


Leu Thr Leu Thr Glu Leu Leu Asn  Asp Leu Tyr Gly Gln  Leu Ile Ser 
        995                 1000                 1005             


Tyr Ser  Tyr Leu Arg Glu Arg  Asp Leu Met Phe Met  Gln Leu Gly 
    1010                 1015                 1020             


Phe Tyr  Tyr Thr Lys Leu Phe  His Thr Ser Ser Val  Pro Ala Gln 
    1025                 1030                 1035             


Asp Lys  Leu Arg Val Leu Ser  Gly Asp Cys Asp Ile  Lys Asp Gly 
    1040                 1045                 1050             


Ala Val  Leu Tyr Gln Ile Ala  Ala Met Tyr Ser Tyr  Asp Leu Pro 
    1055                 1060                 1065             


Ile Tyr  Gly Ile Ser Lys Gln  Gly Val Ala Val Arg  Lys Lys Ser 
    1070                 1075                 1080             


Gly Val  Ser Thr Gly Ala Lys  Leu Asn Gln Phe Ser  Thr Glu Tyr 
    1085                 1090                 1095             


Cys Gly  Gly Lys Trp Asp Ile  Tyr Thr Asn Gly Leu  Tyr Phe Phe 
    1100                 1105                 1110             


Glu Asp  Val Asp Gly Arg His  Lys Asp Tyr Val Glu  Val Arg Asn 
    1115                 1120                 1125             


Tyr Ile  Glu His Phe Lys Tyr  Phe Ala Asp His Lys  Lys Ser Ile 
    1130                 1135                 1140             


Leu Asp  Leu Tyr Ser Asp Leu  Tyr Asn Gly Phe Phe  Ser Tyr Asp 
    1145                 1150                 1155             


Thr Lys  Leu Lys Lys Ser Met  Ser Phe Val Leu Pro  Asn Ile Leu 
    1160                 1165                 1170             


Leu Ser  His Phe Val Asn Ala  Lys Leu Ser Tyr Glu  Lys Asp Val 
    1175                 1180                 1185             


Val Gln  Lys Asn Ser Glu Ser  Tyr Arg Arg Ala Arg  Ile Val Ile 
    1190                 1195                 1200             


Arg Glu  Lys Asp Ile Lys Ser  Asp Phe Leu Thr Tyr  Lys Asn Lys 
    1205                 1210                 1215             


Glu Asn  Ser Lys Ala Phe Tyr  Val Pro Ala Arg Asn  Asp Val Phe 
    1220                 1225                 1230             


Leu Lys  Glu Val Leu Asp Met  Ile Ser Phe Lys Arg  
    1235                 1240                 1245 


<210>  1038
<211>  1184
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1038

Met Arg Val Ser Lys Val Lys Val Leu Gly Asn Glu Glu Thr Lys Gly 
1               5                   10                  15      


Arg Ile Val Leu Met His Arg Ser Pro Val Lys Gly Gln Leu Ile Tyr 
            20                  25                  30          


Ser Glu Asp Ala Gly Lys Arg Asp Arg Thr Glu Asp Ile Ile Pro Glu 
        35                  40                  45              


Gln Lys Leu Glu Ser Phe His Leu Ser Ile Leu Asn Lys Thr Phe Leu 
    50                  55                  60                  


Arg Lys Glu Phe Phe Lys Lys Glu Leu Lys His Glu Ala Lys Lys Asn 
65                  70                  75                  80  


Gly Leu Lys Gly Asp Ala Glu Asp Lys Tyr Ile Ser Glu Lys Leu Lys 
                85                  90                  95      


Glu Tyr His Ser Leu Leu Gln Phe Ile Asp Asp Val Leu Ser Val Lys 
            100                 105                 110         


Tyr Asn Glu Asn Arg Lys Ala Ile Lys Phe Pro Glu Tyr Leu Thr Arg 
        115                 120                 125             


Glu Met Ile Glu Ile Phe Leu Asn His Lys Phe Arg Lys Glu Val Thr 
    130                 135                 140                 


Tyr Thr Asn Lys Asn Gly Ala Ser Val Ser Phe Leu Leu Ser Thr Leu 
145                 150                 155                 160 


Ile Leu Asn Ala Ile Glu Lys His Ser Val Ile Glu Met Gln Pro Phe 
                165                 170                 175     


Val Asp Trp Arg Asn Trp Phe Val Glu Thr Lys Ser Lys Phe Leu Lys 
            180                 185                 190         


Lys Ser Ile Ile Asn Asn Cys Ile Pro Thr Asn Gly Gly Pro Ile Ser 
        195                 200                 205             


Arg Arg Arg Glu Thr Leu Met Lys Trp Arg Asp Asp Tyr Phe Thr Asn 
    210                 215                 220                 


Ala Glu Ile Asp Leu Ala Arg Leu His Lys Lys Phe Gly Thr Asp Thr 
225                 230                 235                 240 


Leu Met Ala Ser Leu Arg Glu Val Pro Gln Thr Glu Lys Ser Gly Asn 
                245                 250                 255     


Glu Tyr His Arg Leu Leu Lys Ser Cys Leu Gln Ser His Gln Lys Lys 
            260                 265                 270         


Leu Phe Gly Lys Arg Ala Glu Gly Tyr Asp Ile Asn Arg Ala Asp Asn 
        275                 280                 285             


Gln Leu Tyr Val Tyr Asn Thr Glu Val Val Lys Tyr Met Glu His Tyr 
    290                 295                 300                 


Phe Pro Val Lys Ser Ser Lys Arg Arg Asn Ser Thr Ala Glu Ile Lys 
305                 310                 315                 320 


Tyr Tyr Leu Gln Thr Asp Thr Ile Lys Cys Cys Leu His His Gln Ile 
                325                 330                 335     


Ile Asn Ala Val Arg Gly Leu Ala Leu Arg Glu Gly Lys Phe Asn Leu 
            340                 345                 350         


His Gly Phe Asp Asp Lys Leu Ile Pro Asn Glu Arg Asn Val Ser Ser 
        355                 360                 365             


Ser Ile Leu Asn Glu Leu Lys Thr Ser Glu Gly Phe Val Leu Asn Met 
    370                 375                 380                 


Leu Gly Gly Cys Ala Phe Ala Ala Asn Cys Leu Arg Asn Ile Val Asp 
385                 390                 395                 400 


Ala Thr Gln Arg Ser Asp Leu Leu Gly Phe Arg Cys Phe Glu Val Ser 
                405                 410                 415     


Leu Lys Lys Gly Lys Ser Asn Ser Asp Leu Phe Ala Leu Phe Phe Gly 
            420                 425                 430         


Phe Gly Arg Glu Asp Met Asp Asp Asp Ser Glu Trp Glu Lys His Leu 
        435                 440                 445             


Tyr Ala Ala Arg Tyr Ser Val Ser Glu Ile Arg Asn Arg Val Ala His 
    450                 455                 460                 


Tyr His Lys Ser Ala Ile Glu Asn Ile Tyr Asn Ile Thr Asp Phe Glu 
465                 470                 475                 480 


Tyr Arg Glu Asn Ser Met Cys Ser Tyr Thr Asp Thr Lys Phe Thr Thr 
                485                 490                 495     


Ala Leu Gln Asn Glu Ile Tyr Asn Thr Pro Lys Ala Phe Ser Leu Gln 
            500                 505                 510         


Leu Met Thr Gly Lys Val Leu Glu Tyr Tyr Pro Lys Glu Lys Leu Val 
        515                 520                 525             


Ser Phe Phe Gln Lys Tyr Lys Phe Ser Leu Tyr Arg Ser Val Val Pro 
    530                 535                 540                 


Phe Ala Pro Gly Phe Lys Asn Ile Met Arg Thr Gly Val Asn Tyr Gln 
545                 550                 555                 560 


Asn Ala Thr Gln Asn Arg Leu Phe Tyr Asp Met Gly Leu Thr Ala Phe 
                565                 570                 575     


Gln Asp Lys Asp Arg Tyr Ile Asp Asp Val Glu Ala Trp Asn Ala Arg 
            580                 585                 590         


Tyr Phe Phe Met Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Arg Phe 
        595                 600                 605             


Thr Asn Asp Lys Asn Asp Leu Phe Arg Lys Thr Val Glu Gln Val Leu 
    610                 615                 620                 


Glu Val Asn Arg Ser His Met Glu Lys Val Gly Lys Asp Asp Arg Gln 
625                 630                 635                 640 


Ala Phe Gly Glu Val Arg Gln Met Arg Glu Asn Glu Thr Ala Asn Asp 
                645                 650                 655     


Tyr Met Ala Tyr Leu Gln Ser Ser Leu Arg Met Glu Lys Asn Lys Lys 
            660                 665                 670         


Glu Leu Glu Gly Asn Gly Ala Lys Arg Ile Asn Phe Glu Lys Phe Ile 
        675                 680                 685             


Leu Gln Met Phe Val Lys Gly Phe Asp Ser Phe Leu Lys Asp Gly Ala 
    690                 695                 700                 


Phe Glu Phe Val His Ser Pro Glu Asn Cys Leu Thr Gly Ser Thr Glu 
705                 710                 715                 720 


Lys Glu Arg Ala Lys Glu Arg Asn Ser Leu Cys Glu Glu Ile Gly Asn 
                725                 730                 735     


Tyr Val Arg Leu Val Ser Thr Val Ile Asp Pro Gly Lys Gly Ser His 
            740                 745                 750         


Val Ala Phe Tyr Val Phe Cys Lys Met Leu Asn Ser Val Tyr Leu Ser 
        755                 760                 765             


Asn Ile Arg Asn Glu Met Ile Lys Tyr His Lys Val Val Arg Thr Asp 
    770                 775                 780                 


Glu Leu Ala His Leu Ile Glu Ile Ile Glu Leu Cys Leu Leu Ser Ala 
785                 790                 795                 800 


Asp Ala Val Ser Gln Lys Thr Val Asn Ala Asp Lys Leu Ser His Phe 
                805                 810                 815     


Phe Ala Glu Gly Val Asn Val Asp Asp Asp Glu Asn Val Ile His Ala 
            820                 825                 830         


Ser Met Glu Thr Phe Arg Lys Tyr Gly Thr Arg Asp Leu Phe His Lys 
        835                 840                 845             


Leu Met Leu Gln Asp Asp Arg Phe Leu Val Ser Ser Asp Asp Tyr Arg 
    850                 855                 860                 


Glu Trp Glu Glu Met Lys Glu Lys Ile Glu Gly Lys Val Lys Gln Arg 
865                 870                 875                 880 


Glu Leu Leu His Ala Glu Trp Cys Glu Ala Lys Glu Lys Asp Lys Lys 
                885                 890                 895     


Ser Arg Lys Val Lys Ser Asn Ser Arg Thr Cys Phe Glu Lys Lys Phe 
            900                 905                 910         


Met Gly Ala Lys Ala Glu Glu Tyr Tyr Ser Leu Cys Asn Val Ile Asp 
        915                 920                 925             


Lys Tyr Asn Trp Leu Asp Asn Lys Leu His Leu Val His Leu Asn Lys 
    930                 935                 940                 


Leu His Asn Leu Val Ile Glu Ile Leu Gly Arg Met Val Gly Phe Thr 
945                 950                 955                 960 


Ala Leu Phe Glu Arg Asp Phe Gln Tyr Ile Cys Lys Ser Asp Ser Glu 
                965                 970                 975     


Tyr Glu Gln Leu Tyr Asn Leu Asp Phe Asn Met Gly Leu Pro Lys Phe 
            980                 985                 990         


Lys Asn Ser Ile Lys Gly Ser Gly  Lys Ala Lys Asn Ser  Thr Gln Asn 
        995                 1000                 1005             


Ile Asp  His Asn Ala Thr Gly  Ile Gly Asn Ser Ser  Asn Leu Leu 
    1010                 1015                 1020             


Lys Glu  Asn Ser Asn Gly Thr  His Tyr Cys Lys Asn  Leu Ser Gly 
    1025                 1030                 1035             


Asp Gly  Val Glu Asp Lys Leu  Lys Arg Leu Phe Leu  Tyr Asp Asp 
    1040                 1045                 1050             


Tyr Arg  Asn Val Arg Asn Phe  Val Ala His Phe Asn  Tyr Leu Thr 
    1055                 1060                 1065             


Arg Val  Glu Asp Asp Leu Gly  Gly Asn Asp Ala Val  Lys Leu Ser 
    1070                 1075                 1080             


Gly Thr  Arg Tyr Ser Leu Ile  Glu Leu Ile Asn Glu  Leu Arg Asn 
    1085                 1090                 1095             


Leu Leu  Lys Tyr Asp Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ser 
    1100                 1105                 1110             


Phe Ile  Asp Met Phe Glu Arg  His Gly Met His Val  Lys Met Lys 
    1115                 1120                 1125             


Leu Asn  His Asn His Lys Leu  Phe Val Asp Ser Ile  Ser Pro Arg 
    1130                 1135                 1140             


Lys Ile  Lys His Leu Gly Gly  Gly Tyr Lys Lys Arg  Gly Lys Asp 
    1145                 1150                 1155             


Asp Lys  Met Tyr Val Gln Thr  Thr Asn His Val Asp  Pro Leu Tyr 
    1160                 1165                 1170             


Cys Asp  Met Cys Arg Ala Leu  Leu Glu Met Lys 
    1175                 1180                 


<210>  1039
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1039

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Thr Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Asp Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val His Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1400                 1405                 1410         


<210>  1040
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1040

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Leu Tyr Gln Ile Val  Ser Ala Phe Asn Phe  Gly Ser Lys 
    1205                 1210                 1215             


Leu Leu  Tyr Ile Ser Glu Asp  Gly Arg Trp Lys Met  Ala Gly Gly 
    1220                 1225                 1230             


Ala Phe  Pro Gly Lys Tyr Gly  Arg Phe Glu Asn Asp  Tyr Asn His 
    1235                 1240                 1245             


Arg Thr  Ser Leu Ser Lys Val  Ile Arg Leu Phe Glu  Asn Glu Ser 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ile Ile Tyr  Trp Arg Asp Tyr Val  Asp His Met 
    1265                 1270                 1275             


Lys Tyr  Tyr Val Asn Gln Asn  Gln Ser Ile Met Glu  Ile Tyr Ser 
    1280                 1285                 1290             


Ala Phe  Tyr Ser Lys Val Leu  Gly Tyr Ser Ala Lys  Leu Arg Lys 
    1295                 1300                 1305             


Ser Val  Val Phe Asn Leu Gln  Ala Ala Leu Glu Lys  His His Ile 
    1310                 1315                 1320             


Asn Pro  Glu Cys Ile Trp Met  Thr Ser Asp Gly Lys  Cys Ala Asp 
    1325                 1330                 1335             


Ile Lys  Leu Met Lys Asn Leu  Glu Ser Gln Lys Phe  Thr Tyr Lys 
    1340                 1345                 1350             


Leu Ala  Lys Arg Glu Gly Glu  Lys Thr Glu Arg Lys  Ile Cys Met 
    1355                 1360                 1365             


Asn Ala  Leu Asn Glu Asn Phe  Leu Lys Thr Ile Arg  Thr Ser Leu 
    1370                 1375                 1380             


Glu Tyr  Lys Lys 
    1385         


<210>  1041
<211>  1419
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1041

Val Arg Thr Pro Phe Leu Arg Ser Ser Phe Thr Ser Arg Leu Cys Leu 
1               5                   10                  15      


Leu Gly Arg Thr Ala Ser Gly Gln Cys Cys Val Ile Glu Tyr Pro Ile 
            20                  25                  30          


Glu Tyr Pro Cys Val Lys Gly Leu Ala Lys Arg Ser Ala Ile Met Ala 
        35                  40                  45              


Lys His Leu Arg Pro Ile Gly Glu Ser Tyr Thr Asp Phe Leu Asp Glu 
    50                  55                  60                  


Thr Glu Phe Val Arg Leu Gly Arg Gly Leu His Arg Gly His His Gly 
65                  70                  75                  80  


Val Gln Ile Pro Pro Thr Glu Leu Pro Ser Tyr Leu Ala Glu Tyr Arg 
                85                  90                  95      


Lys Ala Leu Met Arg Gln Val Val Ala Val Leu Asp Lys Val Val Gly 
            100                 105                 110         


Lys Arg Arg Arg Leu Ser Gly Met His Pro Glu Ala Tyr Arg Asp Arg 
        115                 120                 125             


Val His Leu Ala Glu Ala Leu Trp Val Arg Leu Val Ala Arg Val Lys 
    130                 135                 140                 


Glu Ile Gly Thr Pro Pro Asp Pro Ser Glu Leu Leu Asp Leu Arg Arg 
145                 150                 155                 160 


Met Trp Asn Ala Lys Ala His Pro Tyr Ala Glu Tyr Asp Val Val Pro 
                165                 170                 175     


Arg Ala Pro Leu Asn Asp Gly Asn Gly Gln Lys Ile Leu Glu Cys Arg 
            180                 185                 190         


Glu Val Asp Asp Pro Lys Ile Glu Arg Ser Asp Phe Glu Gly Arg Trp 
        195                 200                 205             


His Gly Arg Phe Trp Gln Ser Glu Pro Gly Pro Val Asp Tyr Asn Ala 
    210                 215                 220                 


Ile Ala Asp Arg Ile Phe Ala His Leu Phe Asp Gln Glu Ala Val Ile 
225                 230                 235                 240 


Gly Gly Gly Pro Arg Arg Glu Gly Asn Val Thr Val Pro Asp Glu Asp 
                245                 250                 255     


Ile Asn Gly Gln Pro Gly Pro Ala Thr Gly Lys Gly Leu Ile Ile Ala 
            260                 265                 270         


Arg Gly Gln Ser Ile Val Lys Ser Ala Ser Asp Pro Arg Arg Ser Ser 
        275                 280                 285             


Lys Lys Val Gln Arg Thr Trp Asp Lys Ala Val Glu Arg Arg Tyr Phe 
    290                 295                 300                 


Gly Asp Asp Gly Lys Gly Gly Ser Asp Ile Ala Lys Ala Ile Tyr Glu 
305                 310                 315                 320 


Glu Leu Gly Asp Pro Ala Thr Leu Ala Asp Pro Ile Tyr Ala Ser Trp 
                325                 330                 335     


Phe Gly Ser Arg Leu Tyr Asp His Phe Gly Ser Phe Lys Asn Ser Leu 
            340                 345                 350         


Pro Leu Glu Leu Lys Asp Pro Phe Lys Glu Gln Ile Trp Ala Leu His 
        355                 360                 365             


Asn Ser Val Arg Gln Phe Tyr Gln Arg Met Ala Lys Ser Asp Arg Phe 
    370                 375                 380                 


Arg Leu Ala Leu Gln Asn Ala Arg Ser Glu Val Pro Asp Arg Ser Glu 
385                 390                 395                 400 


Leu Leu Ala Leu Leu Pro Lys Asp His Asp His Leu Leu Leu Val Leu 
                405                 410                 415     


Gly Gly Lys Lys Lys Asn Ala Glu Met Ser Glu Leu Ile Arg Leu Gly 
            420                 425                 430         


Lys Leu Phe Val His Ala Ser Asp Val Leu His Asp Phe Asp Ala Asn 
        435                 440                 445             


Asp Ala Ala Ala Leu Asp Ala Phe Lys Arg Arg Met Ser Phe Leu Ala 
    450                 455                 460                 


Thr Ser Ile Gly Gln Ser Glu Ile Lys Gln Thr Glu Thr Phe Ala Arg 
465                 470                 475                 480 


Thr Trp Arg Gly Ala Val Gly Leu Thr Leu Arg Thr Val Lys Gly Leu 
                485                 490                 495     


Ala Asp Pro Arg Gly Ile Ile Gly Thr Pro Asp Asn Arg Asp Leu Gly 
            500                 505                 510         


Thr Ala Gly Pro Met Lys Asp Ala Phe Asn Lys Phe Asp Gln Pro His 
        515                 520                 525             


Phe Gln Gln His Met Thr Ile Ile Phe Gly Asn Lys Glu Leu Gln Ala 
    530                 535                 540                 


Glu Gly Asn Pro Thr Arg Ser Ser Val Phe Thr Ala Asn Gly Asp Lys 
545                 550                 555                 560 


Asp His Gln Ala Glu Leu Leu Trp Gly Phe Leu Cys Val Val Arg Ser 
                565                 570                 575     


Val Arg Asn Arg Thr Asn His Tyr Asn Val Arg Arg Ala Leu Leu Arg 
            580                 585                 590         


Leu Leu Asp Glu Gly Ile Val Ser Pro Met Pro Ser Asp Pro Lys Lys 
        595                 600                 605             


Glu Arg Val Glu Asn Arg Asn Leu Cys Thr Val Ser Pro Thr Ala Leu 
    610                 615                 620                 


Glu Ala Phe Arg Arg Leu Leu Asn Phe Asp Leu Ala Ile Gln Lys Glu 
625                 630                 635                 640 


Ala Val Arg Thr Ala Leu Glu Gln Ala Lys Ala Ser Glu Phe Val Glu 
                645                 650                 655     


Glu Gly Lys Leu Arg Gly Leu Val Ser Glu Leu Ala Gly Thr Glu Asp 
            660                 665                 670         


Met Pro Ala Leu His Ile Pro Arg Phe Ser Ala Val Met Asp Lys Val 
        675                 680                 685             


Arg Arg Leu Ala Asp Asn Arg Asp Val Gly Leu Asp Pro Ile Leu Ser 
    690                 695                 700                 


Thr Leu Gln Arg Ser Leu Pro Pro Thr Asp Lys Gln Ala Glu Ser Asp 
705                 710                 715                 720 


Ala Ala Arg Cys Arg Tyr Arg Leu Leu Leu Glu Leu Tyr Lys Ser Gly 
                725                 730                 735     


Phe Arg Ser Trp Phe Ser Gly Ile Gln Ser Asn Glu Glu Asn Asn Arg 
            740                 745                 750         


Glu Ile Cys His Trp Ala Val Lys Gln Val Gly Arg Ala Lys Asp Ala 
        755                 760                 765             


Arg Lys Ser Glu Tyr Asp Lys Lys Thr Lys Arg His Tyr Arg Ser Pro 
    770                 775                 780                 


Asn Ser Leu Ile Asp Asp Leu Gly Leu Asp Lys Phe Asp Asp Leu Thr 
785                 790                 795                 800 


Asp Leu Leu Glu Ala Leu Ala Ser Gln Ser Thr Arg Glu His Asp Gln 
                805                 810                 815     


Asn Leu Lys Tyr Val Pro Asp Ala Arg Val Gln Ser Gln Met Ser Asn 
            820                 825                 830         


Arg Ile Glu Glu Phe Arg Gln Glu Leu Phe Ala His Ile Phe Thr Lys 
        835                 840                 845             


Tyr Leu Asp Thr His Asp Phe Gly Trp Ile Gly Ala Ile Glu Val Arg 
    850                 855                 860                 


Arg Glu Ala Cys Asp Leu Ala Asp Val Val Ser Ala Phe Glu Val Arg 
865                 870                 875                 880 


Asp Gln Lys Phe Asp Ala Asp Trp His Ser Gln Phe Tyr Ala Trp Leu 
                885                 890                 895     


Tyr Met Val Pro Pro Ile Glu Ala Ser Arg Leu Arg His Gln Met Arg 
            900                 905                 910         


Lys Ser Ala Val Met Asp Asp Lys Trp Ser Thr Thr Leu Glu Leu Thr 
        915                 920                 925             


Ser Gly Asp Arg Lys Thr Arg Asp Asp His Ala Gln Asp Val Leu Ala 
    930                 935                 940                 


Asp Met Asp Arg Leu Phe Ser Leu Tyr Thr Lys Val Gln Ala Ala Gly 
945                 950                 955                 960 


Phe Asn Gly Gln Glu His Glu Ser Ala Leu Gly Ser Lys Ser Leu Phe 
                965                 970                 975     


Tyr Glu Asp Gly Asn Gln Phe Asp Glu Val Tyr Ser Pro Asp Thr Glu 
            980                 985                 990         


Thr His Asn Lys Thr Phe Pro Gly  Thr Arg Arg Gly Leu  Arg Gln Leu 
        995                 1000                 1005             


Val Arg  Tyr Ala His Leu Pro  Ala Leu Glu Gly Val  Phe Lys Lys 
    1010                 1015                 1020             


His Arg  Ile Thr Lys Ala Glu  Val Glu Thr Phe Val  Ala Leu Tyr 
    1025                 1030                 1035             


Asp Glu  Asn Arg Arg Asp Pro  Gly Ser Val Ala His  Met Leu Arg 
    1040                 1045                 1050             


Arg Glu  Lys Leu Arg Thr Glu  Ile Leu Arg Ser Ile  His Asp Gly 
    1055                 1060                 1065             


Pro Lys  Pro Lys Asp Lys Asp  Phe Trp Pro Lys Leu  Glu Ala Lys 
    1070                 1075                 1080             


Cys Leu  Glu Tyr Arg Thr Val  Ala Thr Glu Thr Ala  Ile Tyr Asn 
    1085                 1090                 1095             


Phe Gln  Ala Asn Ala Ala Arg  Leu Asn Asp His Ala  Arg Leu His 
    1100                 1105                 1110             


Gln Ile  Val Met Arg Val Val  Ala Arg Leu Thr Asp  Tyr Ala Leu 
    1115                 1120                 1125             


Ile Trp  Glu Arg Asp Arg Leu  Phe Ala Phe Val Gly  Met Leu Tyr 
    1130                 1135                 1140             


Arg Gln  Thr Gly Gly Thr Gly  Ile Asn Pro Ala Met  Arg His Ala 
    1145                 1150                 1155             


Glu Lys  Thr Asn Ala Pro Pro  Arg Ile Gly Ile Leu  Val Ser Asp 
    1160                 1165                 1170             


Ser Ala  Leu Ala Lys Lys Leu  Asn Ser Asn Ser Ala  Glu Val Phe 
    1175                 1180                 1185             


Ile Pro  Tyr Leu Asp Thr Glu  Thr Gly Phe Asp Ala  Pro Arg Phe 
    1190                 1195                 1200             


Asp Asp  Leu Cys Thr Leu Leu  Ser His Glu His Ala  Lys Glu Phe 
    1205                 1210                 1215             


Arg Phe  His Phe Leu Glu Val  Gly Glu Glu Asn Ser  Lys Asp Glu 
    1220                 1225                 1230             


Ala Arg  Arg Leu Asn Glu Glu  Thr Met Gly His Arg  Lys Arg Pro 
    1235                 1240                 1245             


Ala Phe  Lys Arg Gly Thr Arg  Arg Gln Gly Ile Arg  Asn Asp Leu 
    1250                 1255                 1260             


Ala His  His Asn Val Leu Asp  Leu Ala Gly Gly Ala  Gly Pro Asn 
    1265                 1270                 1275             


Leu Thr  Tyr Val Val Asn Ala  Val Arg Ser Leu Leu  Ser Tyr Asp 
    1280                 1285                 1290             


Arg Lys  Leu Lys Asn Ala Val  Pro Lys Ser Ile Lys  Arg Ile Leu 
    1295                 1300                 1305             


Gly Glu  Glu Gly Leu Ile Ile  Glu Trp Gln Met Asn  Tyr Asp Arg 
    1310                 1315                 1320             


Leu Lys  Lys Pro Thr Val Tyr  Pro Asn Val Glu Thr  His Leu Thr 
    1325                 1330                 1335             


Met Val  Pro Pro Arg His Met  Thr Ala Pro Val Ser  Phe Thr Leu 
    1340                 1345                 1350             


Pro Arg  Ala Ser Val Arg Leu  Ala Ser Met Val Lys  Ala Val Phe 
    1355                 1360                 1365             


Asp Phe  Gly Ser Ser Gly Tyr  Gly Glu Glu Arg Met  Ile Gly Gly 
    1370                 1375                 1380             


Arg Thr  Ala Lys Gln Ala Val  Tyr Pro Asp Asp Phe  Thr Arg Arg 
    1385                 1390                 1395             


Phe Pro  Gln Thr Pro Met Gly  Leu Lys Gln Ala Thr  Arg Leu Val 
    1400                 1405                 1410             


Phe Ala  Ser Glu Asn Ser 
    1415                 


<210>  1042
<211>  1250
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1042

Met Lys Ile Val Lys Pro Tyr Gly Leu Ser Ala Thr Asp Lys Lys Gly 
1               5                   10                  15      


Glu Arg Tyr Leu Arg Ala Arg Leu Leu Lys Arg Asn Glu Ala Gly Glu 
            20                  25                  30          


Thr Gln Ile Pro Glu Thr Ala Phe Lys Glu His Glu Phe Gly Glu Phe 
        35                  40                  45              


Asn Gln Ser Asp Pro Arg Ile Leu Ile Gly Gln Trp Ile Ser Ile Ile 
    50                  55                  60                  


Asp Lys Ile Ile Arg Lys Pro Asn Gln Lys Asp Phe Gln Pro Lys Gly 
65                  70                  75                  80  


Met Cys Asp Arg Thr Asn Ser Pro Thr Asn Asn Asp Val Arg Arg Arg 
                85                  90                  95      


Ala Gln Val Lys Phe Arg Thr Glu Leu Gly Arg Ala Cys Trp Asn Leu 
            100                 105                 110         


Leu Glu Glu Arg Lys Leu Leu Asp Arg Lys Ala Leu Asp Asp Phe Ala 
        115                 120                 125             


Pro Ile Trp Ala Gln Lys Leu His Pro Ala Gly Asp Val Pro Glu Glu 
    130                 135                 140                 


Phe Gln Ser Asp Arg Gln Lys Lys Asn Glu Arg Gly Lys Lys Ile Trp 
145                 150                 155                 160 


Glu Asp Asn Lys Pro Val Trp Asp Asp Glu Tyr Ile Leu Asn Ile Thr 
                165                 170                 175     


Gly Leu Trp Tyr Val Arg Phe Met Gly Glu Asp Thr Lys Leu Asp Asn 
            180                 185                 190         


Glu Glu Gln Leu Asp Gln Leu Glu Phe Asp Asn Ile Ala Ala Asp Ile 
        195                 200                 205             


Phe Lys His Leu His Glu Lys Glu Phe Lys Lys His Asp Gly Glu Lys 
    210                 215                 220                 


Ser Ile Gly Leu Ile Glu Ala Arg Ala Ile Ser Val Ala Asn Ser Ser 
225                 230                 235                 240 


Pro Lys Lys His Met Glu Lys Met Trp Val Glu Gly Glu Gly Thr Lys 
                245                 250                 255     


Leu Leu Glu Ser Leu Thr Gln Glu Lys Ile Met Leu Pro Trp Thr Asp 
            260                 265                 270         


Val Asp Glu Lys Ser Phe Ile Asn Gly Lys Arg Val His Ser Leu Ala 
        275                 280                 285             


Glu Gln Ile Ser Ala Thr Asn Ala His Leu Glu Asp Gln Lys Gln Arg 
    290                 295                 300                 


Leu His Tyr Asp Ile Val Gly Gly Tyr Ile Phe Glu His Tyr Arg Lys 
305                 310                 315                 320 


Gln Phe Ile Asp Lys Asp Gly Ala Val Pro Lys Arg Val Asp Ile Ala 
                325                 330                 335     


Lys Glu Arg Phe Gly Leu Leu Ala Leu Tyr Asp Glu Val Arg Ser Leu 
            340                 345                 350         


Tyr Lys Gly Leu Ile Lys Asn Ser Asn Lys Lys Ser Leu Lys Arg Thr 
        355                 360                 365             


Leu Pro Ala Asn Asp Lys Glu Leu Phe Thr Leu Leu Arg Gln Arg His 
    370                 375                 380                 


Ala Asn Lys Ile Thr Asn Asn Leu Ile Arg Leu Gly Lys Ile Leu His 
385                 390                 395                 400 


Tyr Glu Gly Thr Val Gly Asp Gly Asp Gly Phe Gly Leu Ser Leu Asn 
                405                 410                 415     


Lys Ser Gly Asn Ile Lys Gln Gly Gly Gln Asp Ile Phe Ala Leu Asn 
            420                 425                 430         


Leu Lys Asp Ile Ala Asn Ser Ala Tyr Trp Lys Ser Asp Gly Gln Ala 
        435                 440                 445             


Asp Ile Lys Arg Thr Glu Ala Phe Val Arg Ile Trp Arg Asn Thr Ile 
    450                 455                 460                 


Ser Gln Ala Gln Arg Thr Ala Gln Thr Leu Ala Asp Pro Asp Gly Lys 
465                 470                 475                 480 


Phe Ser Lys Ala Leu Gly Arg Pro Leu Asp Val Leu Glu Asp Lys Val 
                485                 490                 495     


Ser Pro Met Leu Ser Thr Asp Asp Lys Val Met Gly Arg Ala Asn Asn 
            500                 505                 510         


Asn Ala Lys Leu Leu Phe Gly Val Gln Ala Lys Leu Phe Glu Asp Val 
        515                 520                 525             


Asp Pro Ser Asp Phe Ile Tyr Gly Thr Leu Arg Leu Leu Ala Asn Ile 
    530                 535                 540                 


Arg Asn Lys Ala Phe His Phe Asn Gly Arg Arg Ala Phe Val Gln Lys 
545                 550                 555                 560 


Met Ile Ser Gly Phe Asp Glu Asp Asn Ile Lys Asn Ile Val Thr His 
                565                 570                 575     


Glu Lys Thr Val Asp Leu Asp Gly Phe Trp Thr Gln Val Lys Ala Leu 
            580                 585                 590         


Leu Ala Ser Asp Gln Met Glu Arg Phe Lys Arg Gln Ile Ser Val Leu 
        595                 600                 605             


Glu Gly Ala Gln Phe Asn Cys Phe Ala Thr Thr Asn Gln Ile Asn Asn 
    610                 615                 620                 


Tyr Leu Lys Leu Leu Ser His Asn Glu Ser Asp Val Ser Leu Pro Arg 
625                 630                 635                 640 


Phe Asn Lys Leu Leu Thr Arg Ile Asp Asn Thr Thr Gln Lys Ile Ser 
                645                 650                 655     


Arg Thr Asn Asn Trp Phe Phe Pro Glu Pro Ala Ser His Val Asp Leu 
            660                 665                 670         


Asn Ala Phe Pro Ala Met Leu Thr Lys Phe Val Gly Leu Lys Ile Leu 
        675                 680                 685             


Tyr Glu Gly Pro Phe Arg Ala Trp Val His Lys Ile Lys Pro Glu Lys 
    690                 695                 700                 


Leu Ala Glu Tyr Arg Asn Ala Ala Ala Asp Leu Gly Ser Lys Ala Ala 
705                 710                 715                 720 


Lys Lys Ile Asn Ser Gln Ser Lys Tyr Pro Glu Leu Ile Arg Ala Lys 
                725                 730                 735     


Thr Glu Asp Leu Pro Leu Ile Ser Lys Ile Asp Thr Ile Ser Ser Tyr 
            740                 745                 750         


Met Asp Thr Leu Gln Ala Phe Gln Ala Ser Glu Gln Arg Leu Gln Lys 
        755                 760                 765             


Gly Tyr Glu Ser Asn Ser Ser Ala Ala Lys Glu Gln Ala Glu Trp Ile 
    770                 775                 780                 


Glu Asn Phe Arg Lys Asp Ile Leu Ala Arg Ala Phe Arg Asp Tyr Leu 
785                 790                 795                 800 


Asn Glu His Phe Ser Gln Leu Lys Trp Leu Leu Glu Leu Lys Lys Ala 
                805                 810                 815     


Asp Ala Pro Arg Glu Pro Gln Ala Met Pro Lys Ala Gly Ser Ala Thr 
            820                 825                 830         


Asp Gly Glu Thr Leu Ser Glu Ser Trp His Ala Ala Leu Tyr Tyr Ile 
        835                 840                 845             


Leu His Leu Val Pro Ala Tyr Glu Val Ser Arg Leu Leu His Gln Ile 
    850                 855                 860                 


Arg Lys Trp Gly Ile Leu Glu Lys Lys Ser Gly Ala Thr Asp Glu Pro 
865                 870                 875                 880 


Asp Thr Asp Val Glu Asn Leu Arg Arg Leu Leu Ile Leu Tyr Ile Glu 
                885                 890                 895     


Met Ser Glu Asp Lys His Thr Gly Glu Gly Ile Ala Leu Glu Gly Met 
            900                 905                 910         


Asp Lys Phe Tyr Asp Met Phe Lys Asp Lys Gln Thr Gly Phe Asp Lys 
        915                 920                 925             


Val Phe Lys Thr Glu Gly Ser Thr Glu Asp Val Leu Ala Ser Thr Arg 
    930                 935                 940                 


Arg Gly Leu Arg Glu Ile Leu Arg Tyr Gly Asn Lys Asn Val Leu Thr 
945                 950                 955                 960 


Val Ala Ile Gly Glu Val Lys Val Thr Asp Asn Asp Ile Thr Ala Tyr 
                965                 970                 975     


Arg Asp Gln Gln Ala Gly Ile Glu Arg Ala Gln Leu Lys Arg Lys Lys 
            980                 985                 990         


Ile His Ser Glu Leu Ile Lys Arg  Ala Gly Asp Lys Asn  Gln Gln Phe 
        995                 1000                 1005             


Val Glu  Tyr Val Thr Ala Leu  Lys Ser Ile Ile Ser  Tyr Arg Glu 
    1010                 1015                 1020             


Leu Ser  His Arg Val Asn Leu  Thr Asn Phe Val Lys  Leu His Lys 
    1025                 1030                 1035             


Ile Met  Leu Gln Val Val Ala  Arg Leu Ile Asp Tyr  Ala Gly Val 
    1040                 1045                 1050             


Trp Glu  Arg Asp Gly Tyr Phe  Ile Ala Thr Ala Leu  Met Lys Ile 
    1055                 1060                 1065             


His Gly  Lys Lys Pro Glu Asp  Val Leu Gly Asp Gly  Ala Pro Trp 
    1070                 1075                 1080             


Phe Arg  Ser Ala Gly Lys Leu  Pro Arg Thr Glu Ser  Met Asp Ile 
    1085                 1090                 1095             


Thr Phe  Leu Gly Gln Leu Ser  Arg Phe Tyr Thr Pro  Gln Leu Thr 
    1100                 1105                 1110             


Gln Ile  Arg Lys Asp Leu His  His Phe Asn Leu Val  Ala Gly Asp 
    1115                 1120                 1125             


Asp Val  Asp Leu Thr Gly Ala  Val Asn Asn Val Arg  Arg Leu Met 
    1130                 1135                 1140             


Ala Tyr  Asp Arg Lys Met Lys  Asn Ala Val Ser Lys  Ser Ile Lys 
    1145                 1150                 1155             


Glu Met  Met Asp Glu Glu Gly  Leu Phe Leu Cys Trp  Lys Met Asp 
    1160                 1165                 1170             


Ala Ser  His Asn Leu Ala Leu  Asp Pro Glu Cys Ile  Arg Asn Gly 
    1175                 1180                 1185             


Gln Lys  Val Pro Ala Ile Glu  Ser Arg Val Ile Lys  His Leu Gln 
    1190                 1195                 1200             


Lys Gly  Trp Arg Pro Lys Arg  Glu Ser Tyr Ala Ala  Arg Gln Lys 
    1205                 1210                 1215             


Asp Asn  Gln Ala Leu Ser Glu  Asn Phe His Asp Asp  Asn Phe Val 
    1220                 1225                 1230             


Arg Ala  Val Thr Cys Leu Phe  Ser Pro Asn Arg Ser  Thr Ser Ser 
    1235                 1240                 1245             


Pro Val  
    1250 


<210>  1043
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1043

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  1044
<211>  1169
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1044

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Gly Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Val Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Met 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Glu 
        275                 280                 285             


Asn Val Lys Tyr Val Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Gly Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Lys Asp Asp Ile Thr Gly Lys Met Arg Gly Lys Thr Arg Ile Asp Ser 
                405                 410                 415     


Lys Thr Gly Glu Glu Lys Tyr Ile Pro Gly Glu Val Asp Gln Ile Tyr 
            420                 425                 430         


Tyr Glu Asn Lys Gln Asn Glu Val Lys Asn Lys Leu Lys Met Phe Tyr 
        435                 440                 445             


Gly Tyr Asp Phe Asp Met Asp Asn Lys Lys Glu Ile Glu Asp Phe Phe 
    450                 455                 460                 


Ala Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His 
465                 470                 475                 480 


Phe Asn Leu Asp Leu Asp Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile 
                485                 490                 495     


Val Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu 
            500                 505                 510         


Lys Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val 
        515                 520                 525             


Phe Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr 
    530                 535                 540                 


Arg Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr 
545                 550                 555                 560 


Lys Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr 
                565                 570                 575     


Trp Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile 
            580                 585                 590         


Asp Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu 
        595                 600                 605             


Asn Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu 
    610                 615                 620                 


Ile Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe 
625                 630                 635                 640 


Tyr Lys Leu Gln Lys Phe Glu Asn Leu Gln Glu Lys Thr Pro Lys Glu 
                645                 650                 655     


Tyr Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln 
            660                 665                 670         


Asp Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe 
        675                 680                 685             


Leu Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu 
    690                 695                 700                 


Ile Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys 
705                 710                 715                 720 


Lys Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn 
                725                 730                 735     


Ile Glu Ile Pro His Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu 
            740                 745                 750         


Gly Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile 
        755                 760                 765             


Leu Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu 
    770                 775                 780                 


Glu Lys Tyr Gln Ser Ala Asn Lys Glu Glu Ala Phe Ser Asp Gln Leu 
785                 790                 795                 800 


Glu Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp 
                805                 810                 815     


Phe Glu Leu Glu Ala Asp Glu Ile Gly Lys Phe Leu Asn Phe Asn Gly 
            820                 825                 830         


Asn Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys 
        835                 840                 845             


Ile Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn 
    850                 855                 860                 


Ile Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu 
865                 870                 875                 880 


Ala Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys 
                885                 890                 895     


Lys Asn Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg 
            900                 905                 910         


Lys Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr 
        915                 920                 925             


Lys Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu 
    930                 935                 940                 


Lys Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Ser Leu Leu 
945                 950                 955                 960 


Leu Arg Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg 
                965                 970                 975     


Asp Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile 
            980                 985                 990         


Glu Glu Ile Phe Asn Phe Glu Asn  Lys Lys Asn Val Lys  Tyr Lys Gly 
        995                 1000                 1005             


Gly Gln  Ile Val Glu Lys Tyr  Ile Lys Phe Tyr Lys  Glu Leu His 
    1010                 1015                 1020             


Gln Asn  Asp Glu Val Lys Ile  Asn Lys Tyr Ser Ser  Ala Asn Ile 
    1025                 1030                 1035             


Lys Val  Leu Lys Gln Glu Lys  Lys Asp Leu Tyr Ile  Arg Asn Tyr 
    1040                 1045                 1050             


Ile Ala  His Phe Asn Tyr Ile  Pro His Ala Glu Ile  Ser Leu Leu 
    1055                 1060                 1065             


Glu Val  Leu Glu Asn Leu Arg  Lys Leu Leu Ser Tyr  Asp Arg Lys 
    1070                 1075                 1080             


Leu Lys  Asn Ala Val Met Lys  Ser Val Val Asp Ile  Leu Lys Glu 
    1085                 1090                 1095             


Tyr Gly  Phe Val Ala Thr Phe  Lys Ile Gly Ala Asp  Lys Lys Ile 
    1100                 1105                 1110             


Gly Ile  Gln Thr Leu Glu Ser  Glu Lys Ile Val His  Leu Lys Lys 
    1115                 1120                 1125             


Leu Lys  Leu Lys Asp Asn Asp  Lys Lys Lys Glu Leu  Ile Lys Thr 
    1130                 1135                 1140             


Tyr Arg  Asn Ser Lys Glu Leu  Cys Lys Leu Val Lys  Val Met Phe 
    1145                 1150                 1155             


Glu Tyr  Lys Met Glu Glu Lys  Ser Ser Glu Lys 
    1160                 1165                 


<210>  1045
<211>  1191
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1045

Met Lys Val Thr Lys Ile Asp Gly Leu Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ile Glu Asp Ala Ser Gln Lys Asn Glu Thr 
            20                  25                  30          


Leu Glu Arg Leu Glu Asn Leu Lys Gly Ile Lys Leu Gly Asn Tyr Ile 
        35                  40                  45              


Lys Asn Pro Asp Lys Thr Lys Asn Lys Asp Asn Lys Lys Arg Arg Lys 
    50                  55                  60                  


Gly Leu Lys Glu Tyr Phe Ser Glu Ile Thr Leu Arg Lys Glu Asn Glu 
65                  70                  75                  80  


Lys Tyr Val Leu Leu Lys Gly Lys Lys Leu Lys Lys Ile Asn Asn Asp 
                85                  90                  95      


Ile Lys Asp Thr Asp Ile Lys Ala Lys Asp Lys Lys Glu Glu Val Phe 
            100                 105                 110         


Asp Ile Leu Lys Glu Ile Leu Lys Leu Asn Leu Leu Ala Asn Asp Ala 
        115                 120                 125             


Glu Glu Lys Ile Gln Phe Asp Ser Ile Lys Leu Lys Asn Val Phe Gly 
    130                 135                 140                 


Lys Asp Phe Val Lys Lys Glu Leu Gln Ile Lys Ser Ile Glu Glu Ser 
145                 150                 155                 160 


Leu Glu Lys Asn Lys Ala Asp Tyr Arg Lys Glu Phe Ile Glu Thr Glu 
                165                 170                 175     


Asn His Lys Tyr Gly Asn Val Lys Gly Lys Asn Lys Arg Ser Arg Ile 
            180                 185                 190         


Tyr Glu Tyr Tyr Lys Lys Ser Glu Asn His Lys Lys Phe Glu Asp Asn 
        195                 200                 205             


Ile Arg Glu Ala Phe Glu Lys Leu Tyr Thr Glu Glu Asn Ile Lys Glu 
    210                 215                 220                 


Leu Tyr Ser Lys Ile Glu Gln Val Leu Lys Lys Thr His Leu Lys Ser 
225                 230                 235                 240 


Ile Val Arg Glu Phe Tyr Gln Asn Glu Ile Ile Gly Glu Ser Glu Phe 
                245                 250                 255     


Ser Lys Lys Asn Gly Asp Gly Ile Ser Ile Leu Tyr Asn Gln Ile Lys 
            260                 265                 270         


Asp Ser Ile Lys Lys Glu Lys Asn Phe Ile Glu Phe Ile Glu Asn Ile 
        275                 280                 285             


Gly Asn Leu Glu Leu Lys Asp Leu Thr Lys Ser Gln Ile Phe Tyr Lys 
    290                 295                 300                 


Tyr Phe Leu Glu Asn Glu Glu Leu Asn Asp Glu Asn Ile Lys Phe Val 
305                 310                 315                 320 


Phe Cys Tyr Phe Val Glu Ile Glu Val Ser Asp Leu Leu Lys Gly Asn 
                325                 330                 335     


Val Tyr Lys Ala Ser Lys Ile Tyr Glu Asn Lys Ile Lys Asn Ile Phe 
            340                 345                 350         


Glu Tyr Gly Lys Leu Lys Asn Leu Ile Val Tyr Lys Leu Glu Asn Lys 
        355                 360                 365             


Leu Asn Asn Tyr Val Arg Asn Cys Gly Lys Tyr Asn Tyr His Met Glu 
    370                 375                 380                 


Asn Gly Asp Ile Ala Thr Ser Asp Ile Asn Met Arg Asn Arg Gln Thr 
385                 390                 395                 400 


Glu Ala Phe Leu Arg Ser Met Ile Gly Val Ser Ser Phe Gly Tyr Phe 
                405                 410                 415     


Ser Leu Arg Asn Ile Leu Gly Val Asn Asp Asp Asp Phe Tyr Glu Ile 
            420                 425                 430         


Glu Glu Asp Leu Thr Glu Glu Glu Arg Lys Asn Glu Ser Asn Val Leu 
        435                 440                 445             


Lys Lys Ala Lys Glu Asp Ile Thr Ser Lys Ser Ile Phe Glu Lys Val 
    450                 455                 460                 


Val Asp Lys Ser Phe Glu Lys Lys Gly Ile His Ser Ile Arg Glu Asn 
465                 470                 475                 480 


Val Lys Met Phe Tyr Gly Asp Ser Phe Asp Lys Ala Asn Glu Asp Glu 
                485                 490                 495     


Leu Lys Gln Phe Phe Val Asn Met Leu Asn Ala Ile Thr Ser Ile Arg 
            500                 505                 510         


His Arg Val Val His Tyr Asn Met Asn Thr Asn Ser Glu Asn Ile Phe 
        515                 520                 525             


Asn Phe Ser Asp Ile Glu Val Ser Arg Leu Leu Lys Ser Ile Phe Glu 
    530                 535                 540                 


Lys Glu Thr Asp Lys Arg Glu Leu Lys Leu Lys Ile Phe Arg Gln Leu 
545                 550                 555                 560 


Asn Ser Ala Gly Val Phe Asp Tyr Trp Glu Asp Trp Glu Ile Glu Lys 
                565                 570                 575     


Tyr Leu Lys Asn Ile Glu Phe Lys Phe Val Asn Lys Asn Ile Pro Phe 
            580                 585                 590         


Val Pro Ser Phe Thr Lys Leu Tyr Asn Arg Ile Asp Asp Leu Lys Gly 
        595                 600                 605             


Asn Asn Ala Leu Lys Leu Gly Ala Ile Asn Ile Pro Lys Arg Lys Glu 
    610                 615                 620                 


Ala Arg Asp Ser Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu 
625                 630                 635                 640 


Phe Ile Glu Lys Phe Val Asn Asn Asn Asp Asn Phe Glu Lys Ile Phe 
                645                 650                 655     


Arg Glu Ile Ile Glu Ile Asn Lys Asn Ala Gly Thr Asn Thr Lys Thr 
            660                 665                 670         


Lys Phe Tyr Lys Leu Glu Lys Phe Glu Thr Leu Lys Ala Asn Thr Pro 
        675                 680                 685             


Thr Glu Tyr Leu Glu Lys Leu Gln Ser Leu His Lys Ile Asn Tyr Asp 
    690                 695                 700                 


Lys Glu Lys Val Glu Glu Ala Lys Asp Ile Tyr Val Asp Phe Val Gln 
705                 710                 715                 720 


Lys Ile Phe Leu Lys Gly Phe Ile Asn Tyr Leu Gln Lys Ser Asn Ser 
                725                 730                 735     


Leu Arg Pro Leu Asn Leu Leu Asn Leu Lys Lys Asp Glu Val Ile Asn 
            740                 745                 750         


Ser Glu Lys Ser Ser Tyr Asp Glu Lys Leu Lys Gln Trp Glu Asn Asn 
        755                 760                 765             


Gly Ser Asn Leu Ser Lys Met Pro Glu Glu Ile Tyr Glu Tyr Ile Lys 
    770                 775                 780                 


Lys Ile Gln Ile Asn Lys Ile Asn Tyr Ser Asp Arg Met Ser Ile Phe 
785                 790                 795                 800 


Tyr Leu Leu Leu Lys Leu Ile Asp His Lys Glu Leu Thr Asn Leu Arg 
                805                 810                 815     


Gly Asn Leu Glu Lys Tyr Glu Ser Met Asn Lys Asn Lys Ile Tyr Ser 
            820                 825                 830         


Glu Glu Leu Asn Ile Val Asn Leu Val Ser Leu Asp Asn Asn Lys Val 
        835                 840                 845             


Arg Ala Asn Phe Ser Val Glu Ala Glu Asp Ile Gly Lys Phe Leu Lys 
    850                 855                 860                 


Thr Glu Thr Leu Ile Lys Asp Ala Arg Gln Leu Asn Asn Phe Ser Glu 
865                 870                 875                 880 


Arg Phe Ser Asp Gly Glu Asn Val Ile Lys His Arg Ser Phe Tyr Asn 
                885                 890                 895     


Ile Lys Lys Tyr Gly Ile Leu Asp Leu Leu Glu Lys Ile Val Ala Lys 
            900                 905                 910         


Ala Asp Leu Lys Ile Thr Lys Glu Glu Ile Lys Lys Tyr Glu Asn Leu 
        915                 920                 925             


Gln Lys Glu Leu Glu Lys Asn Asp Phe Tyr Lys Ile Gln Glu Lys Ile 
    930                 935                 940                 


His Arg Lys Tyr Asn Gln Lys Pro Asn Leu Ile Ser Arg Thr Glu Asn 
945                 950                 955                 960 


Lys Lys Asp Phe Asn Asp Tyr Lys Lys Ala Ile Glu Asn Ile Gln Asn 
                965                 970                 975     


Tyr Thr Gln Leu Lys Asn Lys Ile Glu Phe Asn Asp Leu Asn Leu Leu 
            980                 985                 990         


Gln Ser Leu Leu Phe Arg Ile Leu  His Arg Phe Ala Gly  Tyr Thr Ser 
        995                 1000                 1005             


Leu Trp  Glu Arg Asp Leu Gln  Phe Lys Leu Lys Gly  Glu Phe Pro 
    1010                 1015                 1020             


Glu Asp  Lys Tyr Ile Asp Glu  Ile Phe Asn Ser Asp  Gly Asn Asn 
    1025                 1030                 1035             


Asn Gln  Lys Tyr Lys Asn Gly  Gly Ile Ala Asp Lys  Tyr Ala Asp 
    1040                 1045                 1050             


Phe Leu  Ile Glu Lys Glu Glu  Glu Lys Ser Gly Glu  Ile Leu Lys 
    1055                 1060                 1065             


Lys Asn  Gln Arg Ile Lys Arg  Lys Lys Lys Ile Lys  Glu Asp Leu 
    1070                 1075                 1080             


Glu Ile  Arg Asn Tyr Ile Ala  His Phe Asn Tyr Phe  Pro Asp Ala 
    1085                 1090                 1095             


Thr Lys  Ser Ile Leu Glu Leu  Leu Glu Glu Leu Arg  Glu Leu Leu 
    1100                 1105                 1110             


Lys Tyr  Asp Arg Lys Leu Lys  Asn Ala Val Met Lys  Ser Val Lys 
    1115                 1120                 1125             


Asp Ile  Phe Lys Glu Tyr Gly  Phe Ile Val Glu Phe  Gly Ile Ser 
    1130                 1135                 1140             


His Glu  Ser Asn Ser Lys Lys  Ile Lys Val Val Asn  Val Glu Ser 
    1145                 1150                 1155             


Glu Lys  Ile Lys His Leu Lys  Asn Asn Gly Leu Val  Thr Thr Arg 
    1160                 1165                 1170             


Asn Ser  Glu Asp Leu Cys Asp  Leu Val Lys Val Met  Leu Glu Tyr 
    1175                 1180                 1185             


Lys Lys  Ser 
    1190     


<210>  1046
<211>  937
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1046

Met Lys Val Thr Lys Ile Asp Gly Leu Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ile Glu Asp Ala Ser Gln Lys Asn Glu Thr 
            20                  25                  30          


Leu Glu Arg Leu Glu Asn Leu Lys Gly Ile Lys Leu Gly Asn Tyr Ile 
        35                  40                  45              


Lys Asn Pro Asp Lys Thr Lys Asn Lys Asp Asn Lys Lys Arg Arg Lys 
    50                  55                  60                  


Gly Leu Lys Glu Tyr Phe Ser Glu Ile Thr Leu Arg Lys Glu Asn Glu 
65                  70                  75                  80  


Lys Tyr Val Leu Leu Lys Gly Lys Lys Leu Lys Lys Ile Asn Asn Asp 
                85                  90                  95      


Ile Lys Asp Thr Asp Ile Lys Ala Lys Asp Lys Lys Glu Glu Val Phe 
            100                 105                 110         


Asp Ile Leu Lys Glu Ile Leu Lys Leu Asn Leu Leu Ala Asn Asp Ala 
        115                 120                 125             


Glu Glu Lys Ile Gln Phe Asp Ser Ile Lys Leu Lys Asn Val Phe Gly 
    130                 135                 140                 


Lys Asp Phe Val Lys Lys Glu Leu Gln Ile Lys Ser Ile Glu Glu Ser 
145                 150                 155                 160 


Leu Glu Lys Asn Lys Ala Asp Tyr Arg Lys Glu Phe Ile Glu Thr Glu 
                165                 170                 175     


Asn His Lys Tyr Gly Asn Val Lys Gly Lys Asn Lys Arg Ser Arg Ile 
            180                 185                 190         


Tyr Glu Tyr Tyr Lys Lys Ser Glu Asn His Lys Lys Phe Glu Asp Asn 
        195                 200                 205             


Ile Arg Glu Ala Phe Glu Lys Leu Tyr Thr Glu Glu Asn Ile Lys Glu 
    210                 215                 220                 


Leu Tyr Ser Lys Ile Glu Gln Val Leu Lys Lys Thr His Leu Lys Ser 
225                 230                 235                 240 


Ile Val Arg Glu Phe Tyr Gln Asn Glu Ile Ile Gly Glu Ser Glu Phe 
                245                 250                 255     


Ser Lys Lys Asn Gly Asp Gly Ile Ser Ile Leu Tyr Asn Gln Ile Lys 
            260                 265                 270         


Asp Ser Ile Lys Lys Glu Lys Asn Phe Ile Glu Phe Ile Glu Asn Ile 
        275                 280                 285             


Gly Asn Leu Glu Leu Lys Asp Leu Thr Lys Ser Gln Ile Phe Tyr Lys 
    290                 295                 300                 


Tyr Phe Leu Glu Asn Glu Glu Leu Asn Asp Glu Asn Ile Lys Phe Val 
305                 310                 315                 320 


Phe Cys Tyr Phe Val Glu Ile Glu Val Ser Asp Leu Leu Lys Gly Asn 
                325                 330                 335     


Val Tyr Lys Ala Ser Lys Ile Tyr Glu Asn Lys Ile Lys Asn Ile Phe 
            340                 345                 350         


Glu Tyr Gly Lys Leu Lys Asn Leu Ile Val Tyr Lys Leu Glu Asn Lys 
        355                 360                 365             


Leu Asn Asn Tyr Val Arg Asn Cys Gly Lys Tyr Asn Tyr His Met Glu 
    370                 375                 380                 


Asn Gly Asp Ile Ala Thr Ser Asp Ile Asn Met Arg Asn Arg Gln Thr 
385                 390                 395                 400 


Glu Ala Phe Leu Arg Ser Met Ile Gly Val Ser Ser Phe Gly Tyr Phe 
                405                 410                 415     


Ser Leu Arg Asn Ile Leu Gly Val Asn Asp Asp Asp Phe Tyr Glu Ile 
            420                 425                 430         


Glu Glu Asp Leu Thr Glu Glu Glu Arg Lys Asn Glu Ser Asn Val Leu 
        435                 440                 445             


Lys Lys Ala Lys Glu Asp Ile Thr Ser Lys Ser Ile Phe Glu Lys Val 
    450                 455                 460                 


Val Asp Lys Ser Phe Glu Lys Lys Gly Ile His Ser Ile Arg Glu Asn 
465                 470                 475                 480 


Val Lys Met Phe Tyr Gly Asp Ser Phe Asp Lys Ala Asn Glu Asp Glu 
                485                 490                 495     


Leu Lys Gln Phe Phe Val Asn Met Leu Asn Ala Ile Thr Ser Ile Arg 
            500                 505                 510         


His Arg Val Val His Tyr Asn Met Asn Thr Asn Ser Glu Asn Ile Phe 
        515                 520                 525             


Asn Phe Ser Asp Ile Glu Val Ser Arg Leu Leu Lys Ser Ile Phe Glu 
    530                 535                 540                 


Lys Glu Thr Asp Lys Arg Glu Leu Lys Leu Lys Ile Phe Arg Gln Leu 
545                 550                 555                 560 


Asn Ser Ala Gly Val Phe Asp Tyr Trp Glu Asp Trp Glu Ile Glu Lys 
                565                 570                 575     


Tyr Leu Lys Asn Ile Glu Phe Lys Phe Val Asn Lys Asn Ile Pro Phe 
            580                 585                 590         


Val Pro Ser Phe Thr Lys Leu Tyr Asn Arg Ile Asp Asp Leu Lys Gly 
        595                 600                 605             


Asn Asn Ala Leu Lys Leu Gly Ala Ile Asn Ile Pro Lys Arg Lys Glu 
    610                 615                 620                 


Ala Arg Asp Ser Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu 
625                 630                 635                 640 


Phe Ile Glu Lys Phe Val Asn Asn Asn Asp Asn Phe Glu Lys Ile Phe 
                645                 650                 655     


Arg Glu Ile Ile Glu Ile Asn Lys Asn Ala Gly Thr Asn Thr Lys Thr 
            660                 665                 670         


Lys Phe Tyr Lys Leu Glu Lys Phe Glu Thr Leu Lys Ala Asn Thr Pro 
        675                 680                 685             


Thr Glu Tyr Leu Glu Lys Leu Gln Ser Leu His Lys Ile Asn Tyr Asp 
    690                 695                 700                 


Lys Glu Lys Val Glu Glu Ala Lys Asp Ile Tyr Val Asp Phe Val Gln 
705                 710                 715                 720 


Lys Ile Phe Leu Lys Gly Phe Ile Asn Tyr Leu Gln Lys Ser Asn Ser 
                725                 730                 735     


Leu Arg Pro Leu Asn Leu Leu Asn Leu Lys Lys Asp Glu Val Ile Asn 
            740                 745                 750         


Ser Glu Lys Ser Ser Tyr Asp Glu Lys Leu Lys Gln Trp Glu Asn Asn 
        755                 760                 765             


Gly Ser Asn Leu Ser Lys Met Pro Glu Glu Ile Tyr Glu Tyr Ile Lys 
    770                 775                 780                 


Lys Ile Gln Ile Asn Lys Ile Asn Tyr Ser Asp Arg Met Ser Ile Phe 
785                 790                 795                 800 


Tyr Leu Leu Leu Lys Leu Ile Asp His Lys Glu Leu Thr Asn Leu Arg 
                805                 810                 815     


Gly Asn Leu Glu Lys Tyr Glu Ser Met Asn Lys Asn Lys Ile Tyr Ser 
            820                 825                 830         


Glu Glu Leu Asn Ile Val Asn Leu Val Ser Leu Asp Asn Asn Lys Val 
        835                 840                 845             


Arg Ala Asn Phe Ser Val Glu Ala Glu Asp Ile Gly Lys Phe Leu Lys 
    850                 855                 860                 


Thr Glu Thr Leu Ile Lys Asp Ala Arg Gln Leu Asn Asn Phe Ser Glu 
865                 870                 875                 880 


Arg Phe Ser Asp Gly Glu Asn Val Ile Lys His Arg Ser Phe Tyr Asn 
                885                 890                 895     


Ile Lys Lys Tyr Gly Ile Leu Asp Leu Leu Glu Lys Ile Val Ala Lys 
            900                 905                 910         


Ala Asp Leu Lys Ile Thr Lys Glu Glu Ile Lys Lys Tyr Glu Asn Leu 
        915                 920                 925             


Gln Lys Glu Leu Glu Lys Lys Gln Glu 
    930                 935         


<210>  1047
<211>  1140
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1047

Met Cys Met Lys Ile Thr Lys Ile Asp Gly Val Ser His Tyr Lys Glu 
1               5                   10                  15      


Lys Glu Lys Gly Val Leu Lys Ala Lys Gly Val Leu Asn Glu Glu Ile 
            20                  25                  30          


Gln Lys Ile Val Lys Lys Arg Tyr Asp Lys Thr Ile Glu Ser Lys Ile 
        35                  40                  45              


Tyr Lys Glu Phe Ile Lys Leu Arg Lys Asn Arg Ile Glu Gln Asn Asn 
    50                  55                  60                  


Glu Lys Ser Ile Leu Glu Leu Ile Lys Ser Asn Ile Asp Lys Asn Glu 
65                  70                  75                  80  


Lys Glu Ile Lys Thr Leu Leu Trp Lys Asn Phe Lys Ile Lys Glu Lys 
                85                  90                  95      


Asn Lys Asn Tyr Asp Glu Tyr Ile Thr Asp Glu Ile Lys Leu Asp Asn 
            100                 105                 110         


Asp Ile Lys Ile Tyr Glu Ser Ala Glu Ser Leu Tyr Phe Phe Ile Lys 
        115                 120                 125             


Glu Val Tyr Leu Gly Glu Asn Asn Lys Lys Trp Asn Ile Ser Lys Ile 
    130                 135                 140                 


Asp Leu Glu Lys Ile Met Glu Glu Asp Asn Asn Leu Ile Met Leu Gly 
145                 150                 155                 160 


Tyr Lys Leu Lys Lys Asn Ile Thr Glu Asn Asp Tyr Pro Tyr Leu Tyr 
                165                 170                 175     


Ser Asp Lys Asn Gly Gln Glu Ser Thr Ser Val Tyr Lys Leu Leu Lys 
            180                 185                 190         


Lys Leu Ile Glu Glu Asn Lys Asp Arg Asn Gln Asp Ile Arg Glu Ser 
        195                 200                 205             


Glu Glu Tyr Arg Lys Ile Gln Lys Glu Phe Lys Glu Tyr Lys Asn Arg 
    210                 215                 220                 


Lys Ile Asn Leu Leu Val Lys Ser Ile Leu Asn Asn Lys Val Asn Ile 
225                 230                 235                 240 


Lys Tyr Asn Thr Asn Asn Asn Ser Leu Glu Asp Ser Asn Ser Lys Arg 
                245                 250                 255     


Glu Lys Glu Ile Ile Glu Phe Phe Lys Lys Met Ile Glu Glu Lys Asn 
            260                 265                 270         


Glu Pro Ile Leu Lys Asp Lys Leu Glu Leu Phe Arg Leu Glu Val Phe 
        275                 280                 285             


Phe Asp Glu Glu Phe Leu Glu Glu Ile Lys Lys Leu Leu Asp Ser Asp 
    290                 295                 300                 


Asp Ser Asp Lys Ser Asp Asn Lys Lys Ile Ala Glu Leu Arg Gly Lys 
305                 310                 315                 320 


Ile Phe Ser Arg Ile Arg Glu Lys Ile Lys Glu Asp Lys Asn Arg Asp 
                325                 330                 335     


Ile Leu Lys Asn Ile Tyr Phe Leu Glu Leu Lys Lys Tyr Ile Glu Asn 
            340                 345                 350         


Asn Leu Ser His Lys Lys Glu Lys Asn Lys Asn Asn Asn Asn Thr Gly 
        355                 360                 365             


Glu Glu Lys Arg Lys Glu Leu Tyr Leu Lys Phe Leu Lys Lys Val Leu 
    370                 375                 380                 


Phe Ile Asp Asp Asn Asn Arg Ile Ser Ile Glu Lys Leu Lys Ser Arg 
385                 390                 395                 400 


Ile Asp Asp Asn Phe Lys Asn Leu Leu Ile Gln His Val Ile Glu Tyr 
                405                 410                 415     


Gly Lys Ile Lys Tyr Tyr Val Glu Asn Asp Glu Tyr Ile Lys Asn Ile 
            420                 425                 430         


Val Lys Asn Gly Glu Leu Lys Leu Glu Thr Glu Asn Leu Glu Tyr Ile 
        435                 440                 445             


Arg Ile Arg Glu Thr Leu Ile Arg Lys Met Ala Val Leu Val Ser Phe 
    450                 455                 460                 


Ala Ala Asn Ser Phe Tyr Asn Leu Phe Glu Asn Ile Thr Ser Asp Ile 
465                 470                 475                 480 


Leu Thr Ala Asn Ile Asn Leu Asp Ser Gly Val Ile Lys Ile Gly Asn 
                485                 490                 495     


Asn Arg Leu Lys Glu Lys Phe Leu Asn Tyr Phe Phe Tyr Ser Glu Glu 
            500                 505                 510         


Ile Ser Asp Lys Glu Asp Phe Leu Lys Ala Leu Lys Asp Ser Ile Tyr 
        515                 520                 525             


Asn Val Arg Asn Gly Val Asn His Phe Asp Lys Met Ile Leu Gly Lys 
    530                 535                 540                 


Tyr Asn Asn Gly Leu Asp Leu Lys Asp Ser Asp Thr Ile Lys Asp Tyr 
545                 550                 555                 560 


Phe Asn Phe Lys Lys Lys Glu Ile Gln Gln Asp Leu Lys Asp Arg Phe 
                565                 570                 575     


Ile Ser Asn Asn Leu Gln Tyr Tyr Tyr Thr Glu Asn Glu Ile Lys Lys 
            580                 585                 590         


Tyr Phe Glu Lys Tyr Lys Phe Glu Ile Leu Lys Thr Lys Ala Ser Phe 
        595                 600                 605             


Ala Pro Asn Phe Lys Arg Ile Leu Arg Lys Gly Glu Asn Leu Ser Ile 
    610                 615                 620                 


Ser Glu Ile Ser Asp Ile Tyr Asp Phe Phe Lys Arg Tyr Ser Glu Asn 
625                 630                 635                 640 


Ser Asp Lys Ser Ser Glu Tyr Asn Glu Phe Thr Lys Thr Arg Asn Phe 
                645                 650                 655     


Leu Leu Lys Glu Leu Tyr Tyr Asn Asn Phe Tyr Arg Glu Phe Leu Ser 
            660                 665                 670         


Asp Gly Ile Lys Phe Glu Glu Ala Val Lys Lys Val Lys Lys Asn Lys 
        675                 680                 685             


Lys Asn Arg Ile Ile Gly Lys Lys Lys Ser Ala Gly Lys Ser Tyr Asp 
    690                 695                 700                 


Val Ile Glu Asp Tyr Asn Ser Leu Asp Asp Val Leu Glu Tyr Ile Ser 
705                 710                 715                 720 


Arg Ile His Lys Ser Glu Met Glu Arg Ile Glu Val Asn Thr Glu Lys 
                725                 730                 735     


Asn Arg Lys Asp Thr Ser Lys Tyr Ile Arg Asp Phe Ile Glu Glu Val 
            740                 745                 750         


Phe Leu Glu Gly Phe Ile Lys Tyr Leu Asp Asn Asn Asn Phe Asn Phe 
        755                 760                 765             


Leu Lys Asn Arg Asn Lys Ser Asp Lys Glu Arg Lys Glu Ile Val Arg 
    770                 775                 780                 


Asn Leu Asn Ile Lys Ile Glu Gly Leu Asp Ile Leu Asn Gln Asn Asp 
785                 790                 795                 800 


Ser Glu Ile Leu Asn Leu Tyr Leu Phe Phe Asn Met Ile Asp Asn Lys 
                805                 810                 815     


Arg Ile Ser Glu Phe Arg Asn Glu Met Ile Lys Tyr Lys Gln Phe Leu 
            820                 825                 830         


Thr Lys Arg Gln Asn Ile Lys Ser Lys Phe Leu Glu Ile Asp Ile Glu 
        835                 840                 845             


Lys Ile Glu Ala Ile Ile Glu Phe Val Ile Ile Thr Arg Glu Lys Leu 
    850                 855                 860                 


Glu Ile Leu Glu Asn Glu Ile Lys Glu Gln Asn Lys Asp Asn Met Asn 
865                 870                 875                 880 


Ala Leu Phe Asn Lys Phe Tyr Ser Ser Glu Ser Glu Tyr Asp Glu Cys 
                885                 890                 895     


Leu Lys Lys Phe Ile Glu Glu Thr Val Leu Asn Asp Lys Lys Asn Thr 
            900                 905                 910         


Pro Phe Tyr Ser Thr Asp Gly Lys Thr Pro Ile Val His Ser Asn Leu 
        915                 920                 925             


Glu Lys Met Arg Lys Tyr Gly Thr Glu Asn Phe Leu Ser Lys Val Leu 
    930                 935                 940                 


Lys Gly Glu Lys Tyr Thr Leu Asp Asn Met Arg Ile Lys Glu Lys Phe 
945                 950                 955                 960 


Glu Thr Glu Ala Asn Asp Lys Phe Lys Glu Gln Lys Ile Leu Glu Lys 
                965                 970                 975     


Val Asp Lys Ile Lys Gly Asn Glu Lys His Lys Lys Leu Ile Glu Tyr 
            980                 985                 990         


Tyr Asn Asp Cys Arg Cys Tyr Leu  His Lys Glu Trp Glu  Asn Lys Lys 
        995                 1000                 1005             


Asn Lys  Lys Glu Phe Glu Tyr  Lys Lys Ile Tyr Glu  Lys Ile Ile 
    1010                 1015                 1020             


Glu Glu  Ile Arg Lys Tyr Asn  Tyr Leu Glu Asn Lys  Glu Lys Leu 
    1025                 1030                 1035             


Gln Asn  Val Tyr Leu Leu His  Glu Ile Thr Ser Asp  Leu Met Ala 
    1040                 1045                 1050             


Arg Asn  Val Ala Phe Ile Asn  Lys Trp Glu Arg Asp  Phe Lys Phe 
    1055                 1060                 1065             


Leu Ser  Ile Ala Ile Lys Glu  Asn Leu Lys Asp Ser  Asn Asp Ile 
    1070                 1075                 1080             


Gln Lys  Ile Lys Glu Phe Leu  Ala Pro Ser Leu Asp  Thr Thr Ser 
    1085                 1090                 1095             


Asp Glu  Glu His Phe Asn Val  Lys Asn Tyr Ala Ser  Lys Leu Lys 
    1100                 1105                 1110             


Lys Ile  Gln Gly Leu His Asn  Asn Ile Ile Ser Leu  Ile Phe Ile 
    1115                 1120                 1125             


Lys Asn  Leu Asp Gly Trp Ser  Asn Lys Ile Asp Asn  
    1130                 1135                 1140 


<210>  1048
<211>  1234
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1048

Met Lys Ile Ile Arg Pro Tyr Gly Thr Ser Arg Ser Arg Lys Lys Asp 
1               5                   10                  15      


Glu Gly Leu Arg Arg Val Leu Ile Asp Asn Thr Pro Glu Arg Lys Glu 
            20                  25                  30          


His Pro Ile Pro Arg Phe Ala Ala Ser Arg Asp Glu Leu Val Ile Ala 
        35                  40                  45              


Gln Trp Ile Ser Thr Ile Asp Lys Ile Ala Arg Lys Pro Pro Gly Lys 
    50                  55                  60                  


Lys Lys Pro Thr Pro Ala Gln His Glu Leu Arg His Lys Leu Gly Asn 
65                  70                  75                  80  


Arg Cys Trp Met Arg Leu Ile Glu Gly Gly His Leu Pro Gly Ala Ala 
                85                  90                  95      


Glu Glu Lys Arg Lys Glu His Leu Arg Asn Leu Trp Trp Phe Lys Ile 
            100                 105                 110         


His Pro Tyr Pro Ala Lys Pro Glu Ala Pro Arg Leu Lys Asp Gly Lys 
        115                 120                 125             


Leu Pro Gly Trp Ala Glu Pro Lys Gly Pro Leu Tyr Lys Ala Phe Ile 
    130                 135                 140                 


Gly Asp Cys Glu Pro Glu Glu Ile Asp Pro Asn Lys Ala Ala Glu Ile 
145                 150                 155                 160 


Ala Ala Arg Ile Glu Arg His Leu Tyr Gly Glu Glu Ile Arg Leu Gly 
                165                 170                 175     


Ala His Ala Lys Pro Lys Arg Lys Gly Arg Ile Glu Ala Arg Ala Glu 
            180                 185                 190         


Ser Ile Glu Gly Asn Val Leu His Met Pro Asp Ala Pro Asp Ala Arg 
        195                 200                 205             


Pro Asn Gln Pro Arg Trp Thr Glu Gln Asp Lys Ala Ala Tyr Thr Gln 
    210                 215                 220                 


Pro Gly Asp Pro Ala Gln Thr Ile Arg Gln Lys Ala Glu Ala Leu Glu 
225                 230                 235                 240 


Ala Asn Lys Asp Arg Met Ser Leu Pro Ala Ala Ala Glu Val Leu Phe 
                245                 250                 255     


Ala His Trp Ala Lys Val Phe Arg Asp Pro Gln Ser Gly Arg Thr Leu 
            260                 265                 270         


Gly Val Lys Glu Ala Met Glu Thr Arg Pro Gly Leu Phe Ala Ile His 
        275                 280                 285             


Ser Ala Leu Lys Glu Cys Tyr Arg Arg Leu Leu Lys Arg Thr Arg Lys 
    290                 295                 300                 


Asp Thr Ser Ala Gln Arg Lys Ala Asn Pro Glu Glu Arg Arg Leu Ser 
305                 310                 315                 320 


Thr Leu Leu Pro Arg Asp Leu Lys Gly Ala Leu Arg Leu Ser Glu Leu 
                325                 330                 335     


Gln Ala Lys Asn Ala Glu Leu Ala Glu Leu Val Arg Leu Gly Lys Ile 
            340                 345                 350         


Ile His Tyr Ala Ala Ser Glu Gly Arg Ala Asp Arg Thr Arg Thr Ile 
        355                 360                 365             


Lys Asp His Trp Pro Asp Lys Ile Ala Glu Ser Arg Phe Trp Leu Ser 
    370                 375                 380                 


Asp Gly Gln Ala Asp Ile Lys Arg Ala Glu Ala Phe Val Arg Val Trp 
385                 390                 395                 400 


Arg His Ala Leu Val Leu Ala Gly Leu Thr Leu Lys Asp Leu Thr Gly 
                405                 410                 415     


Tyr Ser Gly Asp Ile Leu Gly Gly Lys Gly Asp Arg Asn Glu Ala Ile 
            420                 425                 430         


Ala Ala Leu Arg Ser Asp Ala Thr Lys Gln Lys His Phe Asp Glu Lys 
        435                 440                 445             


Leu Pro Val Leu Phe Gly His Arg Gln Val Leu Phe Ser Ala Leu Asp 
    450                 455                 460                 


Cys Val Glu Leu Ala Ser Gly Leu Ile Asp Gly Ala Ala Lys Leu Arg 
465                 470                 475                 480 


His Ala Val Phe His Phe Lys Gly Arg Gly Gln Phe Leu Gly Glu Leu 
                485                 490                 495     


Ser Thr Leu Asp Gln Asn Phe Pro Ala Ser Ile Gln Gln Ala Ala Glu 
            500                 505                 510         


Leu Phe Trp Glu Glu Asp Ile Lys Asp Arg Ile Asn Arg Leu Lys Asp 
        515                 520                 525             


Val Leu Thr Ala Ala His Val Gln Lys Phe Leu Thr Gln Glu Gln Ala 
    530                 535                 540                 


Glu Gln Gly Phe Gln Leu Ile Ala Asp Gln Thr Val Thr Glu Leu Pro 
545                 550                 555                 560 


Leu Pro Arg Phe Ser Arg Leu Leu Glu Arg Arg Lys Asn Ala Trp Glu 
                565                 570                 575     


Glu Thr Ile Arg Leu Pro Glu Pro Ala Asn Leu Arg Ala Leu Glu Val 
            580                 585                 590         


Pro Ala Arg Asn Cys Gln Tyr Thr Leu Leu Lys Leu Ile Tyr Glu Arg 
        595                 600                 605             


Pro Phe Arg Ala Trp Leu Lys Ser His Asp Ala Glu Ala Ile Ser Leu 
    610                 615                 620                 


Trp Ile Asp Arg Ala Val Lys Arg Ala Thr Ala Ala Ala Gln Lys Leu 
625                 630                 635                 640 


Asn Ala Ala Asp Ala Ala Gly Arg Glu Val Ile Ala Ala Arg Ala Ala 
                645                 650                 655     


Gly Leu Pro Lys Pro Ser Gly Lys Arg Asp Ile Met Asp Phe Phe Phe 
            660                 665                 670         


Asp Leu Ser Ala Ala Thr Ala Ser Glu Met Arg Val Gln Ser Gly Tyr 
        675                 680                 685             


Gln Ser Asp Arg Glu Gln Ala Arg Glu Gln Ala Gly Tyr Ile Asp Asp 
    690                 695                 700                 


Leu Leu Cys Asp Val Val Ile Leu Ala Phe Ser Asp Tyr Leu Ser Gly 
705                 710                 715                 720 


Gln Lys Leu Asp Trp Leu Leu Asp Leu Lys Leu Asp Gln Glu Pro Ser 
                725                 730                 735     


Lys Leu Pro Thr Cys Ser Leu Asp His Leu Gln Met Pro Glu Gln Gln 
            740                 745                 750         


Pro Glu Leu Val Ala Gln Pro Trp His Ala Ala Leu Tyr Leu Ile Leu 
        755                 760                 765             


His Leu Leu Pro Val Asp Ala Val Gly Gln Leu Leu His Gln Leu Phe 
    770                 775                 780                 


Lys Trp Asn Val Ala Ala Thr Arg Glu Thr Asp Leu Pro Ala Asp Glu 
785                 790                 795                 800 


Asp Glu Arg Arg Lys Arg Leu Glu Ala Thr Met Thr Leu Tyr Leu Asp 
                805                 810                 815     


Met His Asp Ala Lys Phe Glu Gly Gly Phe Ala Leu Ala Gly Cys Glu 
            820                 825                 830         


Asp Phe Ala Asp Leu Phe Lys Asp Lys Glu Ala Phe Lys Lys Phe Ser 
        835                 840                 845             


Ala Gln Ala Ser Arg Glu Glu Pro Asp Arg Arg Val Pro Gln Arg Gly 
    850                 855                 860                 


Leu Arg Glu Ile Ala Arg Phe Gly His Leu Pro Leu Val Lys Thr Leu 
865                 870                 875                 880 


Cys Arg Gly Lys Gln Ile Asp Asp Asp Thr Ile Arg Cys Val Ala Ala 
                885                 890                 895     


Met Glu Ala Ala Pro Glu Gly Gly Glu Ser Gln Ile Ala Leu Leu His 
            900                 905                 910         


Lys Thr Arg Glu Arg Leu His Ala Lys Trp Val Glu Ala Lys Arg Leu 
        915                 920                 925             


Asp Ala Lys Asp Leu Ala Glu Tyr Cys Asp Ala Ile Ala Lys Ile Ser 
    930                 935                 940                 


Glu His Arg Arg Lys Ser Asn Phe Val Asn Leu Val Asp His Val Arg 
945                 950                 955                 960 


Ala His Arg Met Val Leu Ala Pro Leu Gly Arg Leu Val Asp Tyr Ala 
                965                 970                 975     


Gly Leu Phe Glu Arg Asp Leu Tyr Phe Val Thr Leu Ala Leu Leu Lys 
            980                 985                 990         


Gln His Gly Val Arg Pro Glu Asp  Phe Phe Glu Val Ser  Asp Asp Glu 
        995                 1000                 1005             


Arg Lys  Asn Gly Leu Glu Lys  Phe Tyr Asn Gly Glu  Ile Ile Ser 
    1010                 1015                 1020             


Ala Leu  His Asn Cys Lys Val  Asp Ser Pro His Val  Ala Glu Ile 
    1025                 1030                 1035             


Arg Lys  Gln Ile Glu Leu His  Phe Thr Ala Ile Trp  Ala Pro Arg 
    1040                 1045                 1050             


Asn Pro  Ile Arg Glu Ile Arg  Asn Asp Leu Met His  Leu Lys Met 
    1055                 1060                 1065             


Leu Lys  Gly Ala Ala Pro Ala  Pro Arg Leu Thr Tyr  Trp Ile Asn 
    1070                 1075                 1080             


Gln Ala  Arg Arg Leu Met Asp  Tyr Asp Arg Lys Leu  Lys Asn Ala 
    1085                 1090                 1095             


Val Ser  Lys Ser Val Ile Asp  Leu Leu Gln Arg Glu  Gly Leu Thr 
    1100                 1105                 1110             


Leu Arg  Trp Thr Met Ser Thr  Thr Gly Gly Ala His  Asp Leu Ala 
    1115                 1120                 1125             


Gly Ala  Lys Leu Ser Ala Arg  Ser Ala Glu His Leu  Gly Ser Lys 
    1130                 1135                 1140             


Arg Leu  Thr Arg Lys Arg Ala  Gly Pro Lys Asp Lys  Glu Glu Leu 
    1145                 1150                 1155             


Ile His  Glu Arg Leu His Gly  Glu Asp Tyr Val Gly  Met Ile Ala 
    1160                 1165                 1170             


Val Ala  Phe Glu Gly Glu Pro  Val Pro Thr Ile Ser  Ile Leu Asp 
    1175                 1180                 1185             


Asp Leu  Ser Gln Val Asp Trp  Glu Ala Ser Val Ala  Val Lys Arg 
    1190                 1195                 1200             


Pro Arg  Arg Asp Arg Asp Gln  Gly Gly Pro Gln Arg  Pro Ala Ser 
    1205                 1210                 1215             


Asp Arg  Glu Lys Tyr Arg His  Gly Ser Arg Gly Arg  Glu Leu Arg 
    1220                 1225                 1230             


His 
    


<210>  1049
<211>  1373
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1049

Met Ala Lys His Leu Arg Pro Ile Gly Glu Ser Tyr Thr Asp Phe Leu 
1               5                   10                  15      


Asp Glu Thr Glu Phe Val Arg Leu Gly Arg Gly Leu His Arg Gly His 
            20                  25                  30          


His Gly Val Gln Ile Pro Pro Thr Glu Leu Pro Ser Tyr Leu Ala Glu 
        35                  40                  45              


Tyr Arg Lys Ala Leu Met Arg Gln Val Val Ala Val Leu Asp Lys Val 
    50                  55                  60                  


Val Gly Lys Arg Arg Arg Leu Ser Gly Met His Pro Glu Ala Tyr Arg 
65                  70                  75                  80  


Asp Arg Val His Leu Ala Glu Ala Leu Trp Val Arg Leu Val Ala Arg 
                85                  90                  95      


Val Lys Glu Ile Gly Thr Pro Pro Asp Pro Ser Glu Leu Leu Asp Leu 
            100                 105                 110         


Arg Arg Met Trp Asn Ala Lys Ala His Pro Tyr Ala Glu Tyr Asp Val 
        115                 120                 125             


Val Pro Arg Ala Pro Leu Asn Asp Gly Asn Gly Gln Lys Ile Leu Glu 
    130                 135                 140                 


Cys Arg Glu Val Asp Asp Pro Lys Ile Glu Arg Ser Asp Phe Glu Gly 
145                 150                 155                 160 


Arg Trp His Gly Arg Phe Trp Gln Ser Glu Pro Gly Pro Val Asp Tyr 
                165                 170                 175     


Asn Ala Ile Ala Asp Arg Ile Phe Ala His Leu Phe Asp Gln Glu Ala 
            180                 185                 190         


Val Ile Gly Gly Gly Pro Arg Arg Glu Gly Asn Val Thr Val Pro Asp 
        195                 200                 205             


Glu Asp Ile Asn Gly Gln Pro Gly Pro Ala Thr Gly Lys Gly Leu Ile 
    210                 215                 220                 


Ile Ala Arg Gly Gln Ser Ile Val Lys Ser Ala Ser Asp Pro Arg Arg 
225                 230                 235                 240 


Ser Ser Lys Lys Val Gln Arg Thr Trp Asp Lys Ala Val Glu Arg Arg 
                245                 250                 255     


Tyr Phe Gly Asp Asp Gly Lys Gly Gly Ser Asp Ile Ala Lys Ala Ile 
            260                 265                 270         


Tyr Glu Glu Leu Gly Asp Pro Ala Thr Leu Ala Asp Pro Ile Tyr Ala 
        275                 280                 285             


Ser Trp Phe Gly Ser Arg Leu Tyr Asp His Phe Gly Ser Phe Lys Asn 
    290                 295                 300                 


Ser Leu Pro Leu Glu Leu Lys Asp Pro Phe Lys Glu Gln Ile Trp Ala 
305                 310                 315                 320 


Leu His Asn Ser Val Arg Gln Phe Tyr Gln Arg Met Ala Lys Ser Asp 
                325                 330                 335     


Arg Phe Arg Leu Ala Leu Gln Asn Ala Arg Ser Glu Val Pro Asp Arg 
            340                 345                 350         


Ser Glu Leu Leu Ala Leu Leu Pro Lys Asp His Asp His Leu Leu Leu 
        355                 360                 365             


Val Leu Gly Gly Lys Lys Lys Asn Ala Glu Met Ser Glu Leu Ile Arg 
    370                 375                 380                 


Leu Gly Lys Leu Phe Val His Ala Ser Asp Val Leu His Asp Phe Asp 
385                 390                 395                 400 


Ala Asn Asp Ala Ala Ala Leu Asp Ala Phe Lys Arg Arg Met Ser Phe 
                405                 410                 415     


Leu Ala Thr Ser Ile Gly Gln Ser Glu Ile Lys Gln Thr Glu Thr Phe 
            420                 425                 430         


Ala Arg Thr Trp Arg Gly Ala Val Gly Leu Thr Leu Arg Thr Val Lys 
        435                 440                 445             


Gly Leu Ala Asp Pro Arg Gly Ile Ile Gly Thr Pro Asp Asn Arg Asp 
    450                 455                 460                 


Leu Gly Thr Ala Gly Pro Met Lys Asp Ala Phe Asn Lys Phe Asp Gln 
465                 470                 475                 480 


Pro His Phe Gln Gln His Met Thr Ile Ile Phe Gly Asn Lys Glu Leu 
                485                 490                 495     


Gln Ala Glu Gly Asn Pro Thr Arg Ser Ser Val Phe Thr Ala Asn Gly 
            500                 505                 510         


Asp Lys Asp His Gln Ala Glu Leu Leu Trp Gly Phe Leu Cys Val Val 
        515                 520                 525             


Arg Ser Val Arg Asn Arg Thr Asn His Tyr Asn Val Arg Arg Ala Leu 
    530                 535                 540                 


Leu Arg Leu Leu Asp Glu Gly Ile Val Ser Pro Met Pro Ser Asp Pro 
545                 550                 555                 560 


Lys Lys Glu Arg Val Glu Asn Arg Asn Leu Cys Thr Val Ser Pro Thr 
                565                 570                 575     


Ala Leu Glu Ala Phe Arg Arg Leu Leu Asn Phe Asp Leu Ala Ile Gln 
            580                 585                 590         


Lys Glu Ala Val Arg Thr Ala Leu Glu Gln Ala Lys Ala Ser Glu Phe 
        595                 600                 605             


Val Glu Glu Gly Lys Leu Arg Gly Leu Val Ser Glu Leu Ala Gly Thr 
    610                 615                 620                 


Glu Asp Met Pro Ala Leu His Ile Pro Arg Phe Ser Ala Val Met Asp 
625                 630                 635                 640 


Lys Val Arg Arg Leu Ala Asp Asn Arg Asp Val Gly Leu Asp Pro Ile 
                645                 650                 655     


Leu Ser Thr Leu Gln Arg Ser Leu Pro Pro Thr Asp Lys Gln Ala Glu 
            660                 665                 670         


Ser Asp Ala Ala Arg Cys Arg Tyr Arg Leu Leu Leu Glu Leu Tyr Lys 
        675                 680                 685             


Ser Gly Phe Arg Ser Trp Phe Ser Gly Ile Gln Ser Asn Glu Glu Asn 
    690                 695                 700                 


Asn Arg Glu Ile Cys His Trp Ala Val Lys Gln Val Gly Arg Ala Lys 
705                 710                 715                 720 


Asp Ala Arg Lys Ser Glu Tyr Asp Lys Lys Thr Lys Arg His Tyr Arg 
                725                 730                 735     


Ser Pro Asn Ser Leu Ile Asp Asp Leu Gly Leu Asp Lys Phe Asp Asp 
            740                 745                 750         


Leu Thr Asp Leu Leu Glu Ala Leu Ala Ser Gln Ser Thr Arg Glu His 
        755                 760                 765             


Asp Gln Asn Leu Lys Tyr Val Pro Asp Ala Arg Val Gln Ser Gln Met 
    770                 775                 780                 


Ser Asn Arg Ile Glu Glu Phe Arg Gln Glu Leu Phe Ala His Ile Phe 
785                 790                 795                 800 


Thr Lys Tyr Leu Asp Thr His Asp Phe Gly Trp Ile Gly Ala Ile Glu 
                805                 810                 815     


Val Arg Arg Glu Ala Cys Asp Leu Ala Asp Val Val Ser Ala Phe Glu 
            820                 825                 830         


Val Arg Asp Gln Lys Phe Asp Ala Asp Trp His Ser Gln Phe Tyr Ala 
        835                 840                 845             


Trp Leu Tyr Met Val Pro Pro Ile Glu Ala Ser Arg Leu Arg His Gln 
    850                 855                 860                 


Met Arg Lys Ser Ala Val Met Asp Asp Lys Trp Ser Thr Thr Leu Glu 
865                 870                 875                 880 


Leu Thr Ser Gly Asp Arg Lys Thr Arg Asp Asp His Ala Gln Asp Val 
                885                 890                 895     


Leu Ala Asp Met Asp Arg Leu Phe Ser Leu Tyr Thr Lys Val Gln Ala 
            900                 905                 910         


Ala Gly Phe Asn Gly Gln Glu His Glu Ser Ala Leu Gly Ser Lys Ser 
        915                 920                 925             


Leu Phe Tyr Glu Asp Gly Asn Gln Phe Asp Glu Val Tyr Ser Pro Asp 
    930                 935                 940                 


Thr Glu Thr His Asn Lys Thr Phe Pro Gly Thr Arg Arg Gly Leu Arg 
945                 950                 955                 960 


Gln Leu Val Arg Tyr Ala His Leu Pro Ala Leu Glu Gly Val Phe Lys 
                965                 970                 975     


Lys His Arg Ile Thr Lys Ala Glu Val Glu Thr Phe Val Ala Leu Tyr 
            980                 985                 990         


Asp Glu Asn Arg Arg Asp Pro Gly  Ser Val Ala His Met  Leu Arg Arg 
        995                 1000                 1005             


Glu Lys  Leu Arg Thr Glu Ile  Leu Arg Ser Ile His  Asp Gly Pro 
    1010                 1015                 1020             


Lys Pro  Lys Asp Lys Asp Phe  Trp Pro Lys Leu Glu  Ala Lys Cys 
    1025                 1030                 1035             


Leu Glu  Tyr Arg Thr Val Ala  Thr Glu Thr Ala Ile  Tyr Asn Phe 
    1040                 1045                 1050             


Gln Ala  Asn Ala Ala Arg Leu  Asn Asp His Ala Arg  Leu His Gln 
    1055                 1060                 1065             


Ile Val  Met Arg Val Val Ala  Arg Leu Thr Asp Tyr  Ala Leu Ile 
    1070                 1075                 1080             


Trp Glu  Arg Asp Arg Leu Phe  Ala Phe Val Gly Met  Leu Tyr Arg 
    1085                 1090                 1095             


Gln Thr  Gly Gly Thr Gly Ile  Asn Pro Ala Met Arg  His Ala Glu 
    1100                 1105                 1110             


Lys Thr  Asn Ala Pro Pro Arg  Ile Gly Ile Leu Val  Ser Asp Ser 
    1115                 1120                 1125             


Ala Leu  Ala Lys Lys Leu Asn  Ser Asn Ser Ala Glu  Val Phe Ile 
    1130                 1135                 1140             


Pro Tyr  Leu Asp Thr Glu Thr  Gly Phe Asp Ala Pro  Arg Phe Asp 
    1145                 1150                 1155             


Asp Leu  Cys Thr Leu Leu Ser  His Glu His Ala Lys  Glu Phe Arg 
    1160                 1165                 1170             


Phe His  Phe Leu Glu Val Gly  Glu Glu Asn Ser Lys  Asp Glu Ala 
    1175                 1180                 1185             


Arg Arg  Leu Asn Glu Glu Thr  Met Gly His Arg Lys  Arg Pro Ala 
    1190                 1195                 1200             


Phe Lys  Arg Gly Thr Arg Arg  Gln Gly Ile Arg Asn  Asp Leu Ala 
    1205                 1210                 1215             


His His  Asn Val Leu Asp Leu  Ala Gly Gly Ala Gly  Pro Asn Leu 
    1220                 1225                 1230             


Thr Tyr  Val Val Asn Ala Val  Arg Ser Leu Leu Ser  Tyr Asp Arg 
    1235                 1240                 1245             


Lys Leu  Lys Asn Ala Val Pro  Lys Ser Ile Lys Arg  Ile Leu Gly 
    1250                 1255                 1260             


Glu Glu  Gly Leu Ile Ile Glu  Trp Gln Met Asn Tyr  Asp Arg Leu 
    1265                 1270                 1275             


Lys Lys  Pro Thr Val Tyr Pro  Asn Val Glu Thr His  Leu Thr Met 
    1280                 1285                 1290             


Val Pro  Pro Arg His Met Thr  Ala Pro Val Ser Phe  Thr Leu Pro 
    1295                 1300                 1305             


Arg Ala  Ser Val Arg Leu Ala  Ser Met Val Lys Ala  Val Phe Asp 
    1310                 1315                 1320             


Phe Gly  Ser Ser Gly Tyr Gly  Glu Glu Arg Met Ile  Gly Gly Arg 
    1325                 1330                 1335             


Thr Ala  Lys Gln Ala Val Tyr  Pro Asp Asp Phe Thr  Arg Arg Phe 
    1340                 1345                 1350             


Pro Gln  Thr Pro Met Gly Leu  Lys Gln Ala Thr Arg  Leu Val Phe 
    1355                 1360                 1365             


Ala Ser  Glu Asn Ser 
    1370             


<210>  1050
<211>  1167
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1050

Met Lys Val Thr Lys Val Gly Gly Ile Ser His Lys Lys Tyr Thr Ser 
1               5                   10                  15      


Glu Gly Arg Leu Val Lys Ser Glu Ser Glu Glu Asn Arg Thr Asp Glu 
            20                  25                  30          


Arg Leu Ser Ala Leu Leu Asn Met Arg Leu Asp Met Tyr Ile Lys Asn 
        35                  40                  45              


Pro Ser Asn Thr Glu Thr Lys Glu Asn Lys Lys Arg Ile Gly Lys Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Met Val Tyr Leu Lys Asp Asn Thr Leu 
65                  70                  75                  80  


Ser Leu Lys Asn Gly Lys Lys Glu Asn Ile Asp Arg Glu Tyr Ser Glu 
                85                  90                  95      


Thr Asp Ile Ser Glu Tyr Asp Val Arg Asp Ser Lys Asn Phe Ala Val 
            100                 105                 110         


Leu Lys Lys Ile Tyr Leu Asn Glu Asn Val Asn Ser Glu Glu Leu Glu 
        115                 120                 125             


Val Phe Arg Lys Asp Ile Lys Lys Lys Leu Asn Lys Ile Asn Ser Leu 
    130                 135                 140                 


Lys Tyr Ser Phe Glu Lys Asn Lys Ala Asn Tyr Gln Lys Ile Asn Glu 
145                 150                 155                 160 


Asn Asn Ile Glu Lys Val Glu Gly Lys Ser Lys Arg Asn Ile Ile Tyr 
                165                 170                 175     


Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asp Ala Tyr Val Ser Asn Val 
            180                 185                 190         


Lys Glu Ala Phe Asp Lys Leu Tyr Lys Glu Glu Asp Ile Ala Lys Leu 
        195                 200                 205             


Val Leu Lys Ile Glu Asn Leu Thr Lys Leu Glu Lys Ser Lys Ile Arg 
    210                 215                 220                 


Glu Phe Tyr His Glu Ile Ile Gly Arg Lys Asn Asp Lys Glu Asn Phe 
225                 230                 235                 240 


Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Met Lys Glu 
                245                 250                 255     


Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser Gln Val 
            260                 265                 270         


Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Glu Asn Val 
        275                 280                 285             


Lys Tyr Val Phe Cys His Phe Val Glu Ile Glu Met Ser Lys Leu Leu 
    290                 295                 300                 


Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp Lys Val 
305                 310                 315                 320 


Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu Asn Lys 
                325                 330                 335     


Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys Tyr Asn 
            340                 345                 350         


Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile Ala Arg 
        355                 360                 365             


Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val Ser Ser 
    370                 375                 380                 


Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn Lys Asp 
385                 390                 395                 400 


Asp Ile Thr Gly Lys Met Arg Gly Lys Thr Arg Ile Glu Ser Lys Thr 
                405                 410                 415     


Gly Glu Glu Lys Tyr Ile Pro Gly Glu Val Asp Gln Ile Tyr Tyr Glu 
            420                 425                 430         


Asn Lys Gln Asn Glu Val Lys Asn Lys Leu Lys Met Phe Tyr Gly Tyr 
        435                 440                 445             


Asp Phe Asp Met Asp Asn Lys Lys Glu Ile Glu Asp Phe Phe Ala Asn 
    450                 455                 460                 


Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe Asn 
465                 470                 475                 480 


Leu Asp Leu Asp Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Val Pro 
                485                 490                 495     


Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys Lys 
            500                 505                 510         


Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe Arg 
        515                 520                 525             


Tyr Leu Glu Lys Asp Arg Ile Leu Asp Tyr Leu Arg Ser Thr Arg Phe 
    530                 535                 540                 


Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys Leu 
545                 550                 555                 560 


Tyr Asp Arg Ile Asp Asp Leu Lys Ile Ser Leu Asn Ile Tyr Trp Lys 
                565                 570                 575     


Thr Pro Lys Thr Asn Asp Asp Ile Lys Thr Lys Glu Ile Thr Asp Ala 
            580                 585                 590         


Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Lys Phe Leu Asp Tyr 
        595                 600                 605             


Phe Met Ser Arg Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Val Ile 
    610                 615                 620                 


Lys Leu Asn Lys Asn Asn Lys Lys Asn Val Lys Thr Gly Phe Tyr Lys 
625                 630                 635                 640 


Leu Gln Lys Phe Glu Asn Leu Glu Ala Arg Ser Pro Lys Glu Tyr Leu 
                645                 650                 655     


Ala Lys Val Gln Ser Leu Tyr Ile Ile Asn Val Ala Asn Gln Asp Glu 
            660                 665                 670         


Glu Glu Lys Asn Thr Tyr Ile Asp Phe Ile Gln Lys Val Phe Leu Lys 
        675                 680                 685             


Gly Phe Ile Thr Tyr Leu Ala Asn Asn Arg Arg Leu Ser Leu Met Tyr 
    690                 695                 700                 


Ile Gly Ser Asp Glu Glu Val Asn Asn Ser Leu Ala Glu Lys Lys Gln 
705                 710                 715                 720 


Glu Phe Asp Lys Phe Trp Arg Lys Tyr Glu Glu Asn Asn Asp Ile Glu 
                725                 730                 735     


Ile Pro Asp Glu Ile Asn Glu Phe Leu Lys Glu Ile Lys Leu Gly Lys 
            740                 745                 750         


Ile Leu Lys Asn Ser Ala Lys Leu Asn Ile Phe Tyr Leu Ile Leu Lys 
        755                 760                 765             


Leu Leu Asn Asn Lys Glu Phe Thr Asn Leu Lys Gly Asn Leu Glu Lys 
    770                 775                 780                 


Tyr His Ser Ala Asn Glu Val Asn Ile Phe Ser Asp Glu Leu Glu Leu 
785                 790                 795                 800 


Ile Asn Phe Leu Asn Leu Asp Asn Asn Lys Val Lys Glu Asp Phe Glu 
                805                 810                 815     


Phe Glu Ala Asp Glu Ile Gly Lys Phe Leu Asn Phe Asn Gly Asn Lys 
            820                 825                 830         


Ile Lys Asn Arg Glu Glu Leu Lys Lys Phe Asp Thr Thr Lys Met Tyr 
        835                 840                 845             


Phe Tyr Lys Glu Asn Ile Ile Lys Tyr Arg Ala Tyr Tyr Asn Ile Lys 
    850                 855                 860                 


Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala Gly 
865                 870                 875                 880 


Tyr Lys Ile Ser Ile Glu Glu Leu Lys Lys Tyr Ser Asn Lys Lys Asn 
                885                 890                 895     


Glu Ile Glu Lys Asn His Lys Met Gln Glu Asn Leu His Arg Lys Tyr 
            900                 905                 910         


Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Glu Ser 
        915                 920                 925             


Tyr Lys Gln Ala Ile Lys Asn Ile Glu Glu Tyr Thr His Leu Lys Asn 
    930                 935                 940                 


Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu Arg 
945                 950                 955                 960 


Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp Leu 
                965                 970                 975     


Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu Glu 
            980                 985                 990         


Ile Phe Asn Phe Glu Asn Lys Lys  Asn Met Lys Tyr Lys  Ser Gly Gln 
        995                 1000                 1005             


Ile Val  Glu Lys Tyr Ile Lys  Phe Tyr Lys Glu Leu  His Gln Asn 
    1010                 1015                 1020             


Asp Glu  Val Lys Ile Asn Lys  Tyr Ser Ser Ala Asn  Ile Lys Val 
    1025                 1030                 1035             


Leu Lys  Gln Glu Lys Lys Asp  Leu Tyr Ile Arg Asn  Tyr Ile Ala 
    1040                 1045                 1050             


His Phe  Asn Tyr Ile Pro His  Ala Glu Ile Ser Leu  Leu Glu Val 
    1055                 1060                 1065             


Leu Glu  Asn Leu Arg Lys Leu  Leu Ser Tyr Asp Arg  Lys Leu Lys 
    1070                 1075                 1080             


Asn Ala  Val Met Lys Ser Val  Val Asp Ile Leu Lys  Glu Tyr Gly 
    1085                 1090                 1095             


Phe Val  Val Lys Phe Lys Ile  Gly Ala Asp Lys Lys  Ile Glu Ile 
    1100                 1105                 1110             


Gln Ser  Leu Lys Ser Glu Glu  Ile Val His Leu Lys  Lys Leu Lys 
    1115                 1120                 1125             


Leu Lys  Asp Asn Asp Lys Lys  Lys Glu Pro Ile Lys  Thr Tyr Arg 
    1130                 1135                 1140             


Asn Ser  Lys Glu Leu Cys Lys  Leu Val Lys Val Met  Phe Glu Tyr 
    1145                 1150                 1155             


Lys Met  Glu Glu Lys Ser Ser  Glu Lys 
    1160                 1165         


<210>  1051
<211>  1234
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1051

Met Lys Ile Ile Arg Pro Tyr Gly Thr Ser Arg Ser Arg Lys Lys Asp 
1               5                   10                  15      


Glu Gly Leu Arg Arg Val Leu Ile Asp Asn Thr Pro Glu Arg Lys Glu 
            20                  25                  30          


His Pro Ile Pro Arg Phe Ala Ala Ser Arg Asp Glu Leu Val Ile Ala 
        35                  40                  45              


Gln Trp Ile Ser Thr Ile Asp Lys Ile Ala Arg Lys Pro Pro Gly Lys 
    50                  55                  60                  


Lys Lys Pro Thr Pro Ala Gln His Glu Leu Arg His Lys Leu Gly Asn 
65                  70                  75                  80  


Arg Cys Trp Met Arg Leu Ile Glu Gly Gly His Leu Pro Gly Ala Ala 
                85                  90                  95      


Glu Glu Lys Arg Lys Glu His Leu Arg Asn Leu Trp Trp Phe Lys Ile 
            100                 105                 110         


His Pro Tyr Pro Ala Lys Pro Glu Ala Pro Arg Leu Lys Asp Gly Lys 
        115                 120                 125             


Leu Pro Gly Trp Ala Glu Pro Lys Gly Pro Leu Tyr Lys Ala Phe Ile 
    130                 135                 140                 


Gly Asp Cys Glu Pro Glu Glu Ile Asp Pro Asn Lys Ala Ala Glu Ile 
145                 150                 155                 160 


Ala Ala Arg Ile Glu Arg His Leu Tyr Gly Glu Glu Ile Arg Leu Gly 
                165                 170                 175     


Ala His Ala Lys Pro Lys Arg Lys Gly Arg Ile Glu Ala Arg Ala Glu 
            180                 185                 190         


Ser Ile Glu Gly Asn Val Leu His Met Pro Asp Ala Pro Asp Ala Arg 
        195                 200                 205             


Pro Asn Gln Pro Arg Trp Thr Glu Gln Asp Lys Ala Ala Tyr Thr Gln 
    210                 215                 220                 


Pro Gly Asp Pro Ala Gln Thr Ile Arg Gln Lys Ala Glu Ala Leu Glu 
225                 230                 235                 240 


Ala Asn Lys Asp Arg Met Ser Leu Pro Ala Ala Ala Glu Val Leu Phe 
                245                 250                 255     


Ala His Trp Ala Lys Val Phe Arg Asp Pro Gln Ser Gly Arg Thr Leu 
            260                 265                 270         


Gly Val Lys Glu Ala Met Glu Thr Arg Pro Gly Leu Phe Ala Ile His 
        275                 280                 285             


Ser Ala Leu Lys Glu Cys Tyr Arg Arg Leu Leu Lys Arg Thr Arg Lys 
    290                 295                 300                 


Asp Thr Ser Ala Gln Arg Lys Ala Asn Pro Glu Glu Arg Arg Leu Ser 
305                 310                 315                 320 


Thr Leu Leu Pro Arg Asp Leu Lys Gly Ala Leu Arg Leu Ser Glu Leu 
                325                 330                 335     


Gln Ala Lys Asn Ala Glu Leu Ala Glu Leu Val Arg Leu Gly Lys Ile 
            340                 345                 350         


Ile His Tyr Ala Ala Ser Glu Gly Arg Ala Asp Arg Thr Arg Thr Ile 
        355                 360                 365             


Lys Asp His Trp Pro Asp Lys Ile Ala Glu Ser Arg Phe Trp Leu Ser 
    370                 375                 380                 


Asp Gly Gln Ala Asp Ile Lys Arg Ala Glu Ala Phe Val Arg Val Trp 
385                 390                 395                 400 


Arg His Ala Leu Val Leu Ala Gly Leu Thr Leu Lys Asp Leu Thr Gly 
                405                 410                 415     


Tyr Ser Gly Asp Ile Leu Gly Gly Lys Gly Asp Arg Asn Glu Ala Ile 
            420                 425                 430         


Ala Ala Leu Arg Ser Asp Ala Thr Lys Gln Lys His Phe Asp Glu Lys 
        435                 440                 445             


Leu Pro Val Leu Phe Gly His Arg Gln Val Leu Phe Ser Ala Leu Asp 
    450                 455                 460                 


Cys Val Glu Leu Ala Ser Gly Leu Ile Asp Gly Ala Ala Lys Leu Arg 
465                 470                 475                 480 


His Ala Val Phe His Phe Lys Gly Arg Gly Gln Phe Leu Gly Glu Leu 
                485                 490                 495     


Ser Thr Leu Asp Gln Asn Phe Pro Ala Ser Ile Gln Gln Ala Ala Glu 
            500                 505                 510         


Leu Phe Trp Glu Glu Asp Ile Lys Asp Arg Ile Asn Arg Leu Lys Asp 
        515                 520                 525             


Val Leu Thr Ala Ala His Val Gln Lys Phe Leu Thr Gln Glu Gln Ala 
    530                 535                 540                 


Glu Gln Gly Phe Gln Leu Ile Ala Asp Gln Thr Val Thr Glu Leu Pro 
545                 550                 555                 560 


Leu Pro Arg Phe Ser Arg Leu Leu Glu Arg Arg Lys Asn Ala Trp Glu 
                565                 570                 575     


Glu Thr Ile Arg Leu Pro Glu Pro Ala Asn Leu Arg Ala Leu Glu Val 
            580                 585                 590         


Pro Ala Arg Asn Cys Gln Tyr Thr Leu Leu Lys Leu Ile Tyr Glu Arg 
        595                 600                 605             


Pro Phe Arg Ala Trp Leu Lys Ser His Asp Ala Glu Ala Ile Ser Leu 
    610                 615                 620                 


Trp Ile Asp Arg Ala Val Lys Arg Ala Thr Ala Ala Ala Gln Lys Leu 
625                 630                 635                 640 


Asn Ala Ala Asp Ala Ala Gly Arg Glu Val Ile Ala Ala Arg Ala Ala 
                645                 650                 655     


Gly Leu Pro Lys Pro Ser Gly Lys Arg Asp Ile Met Asp Phe Phe Phe 
            660                 665                 670         


Asp Leu Ser Ala Ala Thr Ala Ser Glu Met Arg Val Gln Ser Gly Tyr 
        675                 680                 685             


Gln Ser Asp Arg Glu Gln Ala Arg Glu Gln Ala Gly Tyr Ile Asp Asp 
    690                 695                 700                 


Leu Leu Cys Asp Val Val Ile Leu Ala Phe Ser Asp Tyr Leu Ser Gly 
705                 710                 715                 720 


Gln Lys Leu Asp Trp Leu Leu Asp Leu Lys Leu Asp Gln Glu Pro Ser 
                725                 730                 735     


Lys Leu Pro Thr Cys Ser Leu Asp His Leu Gln Met Pro Glu Gln Gln 
            740                 745                 750         


Pro Glu Leu Val Ala Gln Pro Trp His Ala Ala Leu Tyr Leu Ile Leu 
        755                 760                 765             


His Leu Leu Pro Val Asp Ala Val Gly Gln Leu Leu His Gln Leu Phe 
    770                 775                 780                 


Lys Trp Asn Val Ala Ala Thr Arg Glu Thr Asp Leu Pro Ala Asp Glu 
785                 790                 795                 800 


Asp Glu Arg Arg Lys Arg Leu Glu Ala Thr Met Thr Leu Tyr Leu Asp 
                805                 810                 815     


Met His Asp Ala Lys Phe Glu Gly Gly Phe Ala Leu Ala Gly Cys Glu 
            820                 825                 830         


Asp Phe Ala Asp Leu Phe Lys Asp Lys Glu Ala Phe Lys Lys Phe Ser 
        835                 840                 845             


Ala Gln Ala Ser Arg Glu Glu Pro Asp Arg Arg Val Pro Gln Arg Gly 
    850                 855                 860                 


Leu Arg Glu Ile Ala Arg Phe Gly His Leu Pro Leu Val Lys Thr Leu 
865                 870                 875                 880 


Cys Arg Gly Lys Gln Ile Asp Asp Asp Thr Ile Arg Cys Val Ala Ala 
                885                 890                 895     


Met Glu Ala Ala Pro Glu Gly Gly Glu Ser Gln Ile Ala Leu Leu His 
            900                 905                 910         


Lys Thr Arg Glu Arg Leu His Ala Lys Trp Val Glu Ala Lys Arg Leu 
        915                 920                 925             


Asp Ala Lys Asp Leu Ala Glu Tyr Cys Asp Ala Ile Ala Lys Ile Ser 
    930                 935                 940                 


Glu His Arg Arg Lys Ser Asn Phe Val Asn Leu Val Asp His Val Arg 
945                 950                 955                 960 


Ala His Arg Met Val Leu Ala Pro Leu Gly Arg Leu Val Asp Tyr Ala 
                965                 970                 975     


Gly Leu Phe Glu Arg Asp Leu Tyr Phe Val Thr Leu Ala Leu Leu Lys 
            980                 985                 990         


Gln His Gly Val Arg Pro Glu Asp  Phe Phe Glu Val Ser  Asp Asp Glu 
        995                 1000                 1005             


Arg Lys  Asn Gly Leu Glu Lys  Phe Tyr Asn Gly Glu  Ile Ile Ser 
    1010                 1015                 1020             


Ala Leu  His Asn Cys Lys Val  Asp Ser Pro His Val  Ala Glu Ile 
    1025                 1030                 1035             


Arg Lys  Gln Ile Glu Leu His  Phe Thr Ala Ile Trp  Ala Pro Arg 
    1040                 1045                 1050             


Asn Pro  Ile Arg Glu Ile Arg  Asn Asp Leu Met His  Leu Lys Met 
    1055                 1060                 1065             


Leu Lys  Gly Ala Ala Pro Ala  Pro Arg Leu Thr Tyr  Trp Ile Asn 
    1070                 1075                 1080             


Gln Ala  Arg Arg Leu Met Asp  Tyr Asp Arg Lys Leu  Lys Asn Ala 
    1085                 1090                 1095             


Val Ser  Lys Ser Val Ile Asp  Leu Leu Gln Arg Glu  Gly Leu Thr 
    1100                 1105                 1110             


Leu Arg  Trp Thr Met Ser Thr  Thr Gly Gly Ala His  Asp Leu Ala 
    1115                 1120                 1125             


Gly Ala  Lys Leu Ser Ala Arg  Ser Ala Glu His Leu  Gly Ser Lys 
    1130                 1135                 1140             


Arg Leu  Thr Arg Lys Arg Ala  Gly Pro Lys Asp Lys  Glu Glu Leu 
    1145                 1150                 1155             


Ile His  Glu Arg Leu His Gly  Glu Asp Tyr Val Gly  Met Ile Ala 
    1160                 1165                 1170             


Val Ala  Phe Glu Gly Glu Pro  Val Pro Thr Ile Ser  Ile Leu Asp 
    1175                 1180                 1185             


Asp Leu  Ser Gln Val Asp Trp  Glu Ala Ser Val Ala  Val Lys Arg 
    1190                 1195                 1200             


Pro Arg  Arg Asp Arg Asp Gln  Gly Gly Pro Gln Arg  Pro Ala Ser 
    1205                 1210                 1215             


Asp Arg  Glu Lys Tyr Arg His  Gly Ser Arg Gly Arg  Glu Leu Arg 
    1220                 1225                 1230             


His 
    


<210>  1052
<211>  1157
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1052

Met Leu Arg Arg Met Cys Met Lys Ile Thr Lys Ile Asp Gly Ile Ser 
1               5                   10                  15      


His Lys Lys Tyr Lys Glu Lys Gly Lys Leu Ile Lys Ser Asn Glu Ile 
            20                  25                  30          


Glu Lys Asp Ile Thr Glu Glu Arg Phe Asn Asp Ile Glu Ala Lys Thr 
        35                  40                  45              


Thr Glu Leu Phe Gln Lys Thr Leu Asp Phe Tyr Val Lys Asn Tyr Glu 
    50                  55                  60                  


Asn Ser Glu Asp Gln Asn Lys Glu Arg Arg Glu Lys Ala Lys Asn Tyr 
65                  70                  75                  80  


Phe Ser Lys Val Lys Ile Leu Val Asp Asn Lys Lys Ile Thr Ile Cys 
                85                  90                  95      


Asn Glu Asn Thr Glu Lys Met Glu Ile Glu Asp Phe Asn Glu Tyr Asp 
            100                 105                 110         


Val Arg Ser Gly Lys Tyr Phe Asn Val Leu Asn Lys Ile Leu Asn Gly 
        115                 120                 125             


Glu Asn Tyr Thr Glu Glu Asp Leu Glu Val Phe Glu Asn Asp Leu Gln 
    130                 135                 140                 


Lys Arg Ile Gly Arg Ile Lys Ser Ile Lys Asn Ser Leu Glu Glu Asn 
145                 150                 155                 160 


Lys Ala His Phe Lys Lys Glu Ser Ile Asn Asn Asn Ile Ile Tyr Asp 
                165                 170                 175     


Arg Val Lys Gly Asn Asn Lys Lys Ser Leu Phe Tyr Glu Tyr Tyr Arg 
            180                 185                 190         


Ile Ser Ser Lys His Gln Glu Tyr Val Asn Asn Ile Phe Glu Ala Phe 
        195                 200                 205             


Asp Lys Leu Tyr Ser Asn Ser His Glu Ala Met Asn Asn Leu Phe Ser 
    210                 215                 220                 


Glu Ile Thr Lys Asp Ser Lys Glu Arg Asn Ile Arg Lys Thr Arg Glu 
225                 230                 235                 240 


Ala Tyr His Glu Ile Leu Asn Lys Asn Lys Thr Glu Phe Gly Glu Glu 
                245                 250                 255     


Leu Tyr Lys Lys Ile Gln Asp Asn Ile Ser Asn Phe Asp Lys Leu Leu 
            260                 265                 270         


Glu Ile Glu Pro Glu Ile Lys Glu Leu Thr Lys Ser Gln Ile Phe Tyr 
        275                 280                 285             


Lys Tyr Tyr Ile Asp Lys Val Asn Leu Asp Glu Thr Thr Ile Lys His 
    290                 295                 300                 


Cys Phe Cys His Leu Val Glu Ile Glu Val Asn Gln Leu Leu Lys Asn 
305                 310                 315                 320 


Tyr Val Tyr Ser Lys Arg Asn Ile Asn Lys Glu Lys Leu Glu Asn Ile 
                325                 330                 335     


Phe Glu Tyr Cys Lys Leu Lys Asn Leu Val Lys Asn Lys Leu Val Asn 
            340                 345                 350         


Lys Leu Asn Asn Tyr Ile Arg Asn Cys Gly Lys Tyr Asn Ala Tyr Ile 
        355                 360                 365             


Ser Asn Asn Asp Val Val Val Asn Ser Glu Lys Ile Ser Glu Ile Arg 
    370                 375                 380                 


Thr Lys Glu Ala Phe Leu Arg Ser Ile Ile Gly Val Ser Ser Ser Ala 
385                 390                 395                 400 


Tyr Phe Ser Leu Arg Asn Ile Leu Asn Thr Asp Asn Thr Gln Asp Ile 
                405                 410                 415     


Thr Asn Lys Val Asp Lys Glu Val Asp Lys Leu Tyr Gln Glu Asn Lys 
            420                 425                 430         


Lys Ile Glu Leu Glu Glu Arg Leu Lys Leu Phe Phe Gly Asn Tyr Phe 
        435                 440                 445             


Asp Ile Asn Asn Gln Gln Glu Ile Lys Val Phe Leu Met Asn Ile Asp 
    450                 455                 460                 


Lys Ile Ile Ser Ser Ile Arg His Glu Ile Ile His Phe Lys Met Glu 
465                 470                 475                 480 


Thr Asn Ala Gln Asn Ile Phe Asp Phe Asn Asn Val Asn Leu Gly Asn 
                485                 490                 495     


Thr Ala Lys Asn Ile Phe Ser Asn Glu Ile Asn Glu Glu Lys Ile Lys 
            500                 505                 510         


Phe Lys Ile Phe Lys Gln Leu Asn Ser Ala Asn Ile Phe Asp Tyr Leu 
        515                 520                 525             


Ser Asn Lys Asp Ile Thr Glu Tyr Met Asp Lys Val Val Phe Ser Phe 
    530                 535                 540                 


Thr Asn Arg Asn Val Ser Phe Val Pro Ser Phe Thr Lys Ile Tyr Asn 
545                 550                 555                 560 


Arg Val Gln Asp Leu Ala Asn Ser Leu Glu Ile Lys Glu Trp Lys Ile 
                565                 570                 575     


Pro Asp Glu Ser Glu Gly Lys Asp Ala Gln Ile Tyr Leu Leu Lys Asn 
            580                 585                 590         


Ile Tyr Tyr Gly Lys Phe Leu Asp Lys Phe Leu Asn Glu Glu Asn Gly 
        595                 600                 605             


Ile Phe Ile Ser Ile Lys Asp Lys Ile Ile Glu Leu Asn Arg Asn Gln 
    610                 615                 620                 


Asn Lys Arg Thr Gly Phe Tyr Lys Leu Glu Lys Phe Glu Lys Ile Glu 
625                 630                 635                 640 


Glu Thr Asn Pro Lys Lys Tyr Leu Glu Ile Ile Gln Ser Leu Tyr Met 
                645                 650                 655     


Ile Asn Ile Glu Glu Ile Asp Ser Glu Gly Lys Asn Ile Phe Leu Asp 
            660                 665                 670         


Phe Ile Gln Lys Ile Phe Leu Lys Gly Phe Phe Glu Phe Ile Lys Asn 
        675                 680                 685             


Asp Tyr Asn Tyr Leu Leu Glu Leu Lys Lys Val Gln Asp Lys Lys Asn 
    690                 695                 700                 


Ile Phe Asp Ser Lys Met Ser Glu Tyr Ile Ala Gly Glu Lys Thr Leu 
705                 710                 715                 720 


Glu Asp Ile Gly Glu Ile Asn Glu Ile Ile Gln Lys Ile Glu Ile Thr 
                725                 730                 735     


Lys Ile Asp Lys Ile Leu Asn Gln Thr Asp Arg Ile Asn Ser Phe Tyr 
            740                 745                 750         


Leu Leu Leu Lys Leu Leu Asn Tyr Lys Glu Ile Thr Glu Leu Lys Gly 
        755                 760                 765             


Asn Leu Glu Lys Tyr Gln Ile Leu Ser Lys Thr Asn Val Tyr Glu Lys 
    770                 775                 780                 


Glu Leu Met Leu Leu Asn Ile Val Asn Leu Asp Asn Asn Lys Val Lys 
785                 790                 795                 800 


Ile Glu Asn Phe Lys Ile Ser Ala Glu Glu Ile Gly Lys Phe Ile Glu 
                805                 810                 815     


Lys Ile Asn Ile Glu Glu Ile Asn Lys Lys Ile Lys Thr Phe Glu Glu 
            820                 825                 830         


Leu Arg Asn Phe Glu Lys Gly Glu Asn Thr Gly Glu Tyr Tyr Asn Ile 
        835                 840                 845             


Tyr Ser Asp Asp Lys Asn Ile Lys Asn Ile Arg Asn Leu Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asp Leu Leu Glu Lys Ile Ser Glu Lys Thr 
865                 870                 875                 880 


Asn Tyr Cys Ile Lys Lys Lys Asp Leu Glu Glu Tyr Ser Lys Leu Arg 
                885                 890                 895     


Lys Gln Leu Glu Asp Lys Lys Lys Glu Asn Glu Lys Ile Glu Asp Glu 
            900                 905                 910         


Lys Thr Asn Phe Tyr Lys Ile Gln Glu Tyr Leu His Ser Lys Tyr Gln 
        915                 920                 925             


Gln Glu Pro Lys Lys Ile Leu Trp Lys Asn Asn Lys Asn Asp Tyr Glu 
    930                 935                 940                 


Lys Tyr Lys Lys Ser Ile Glu Asn Ile Glu Lys Tyr Val His Leu Lys 
945                 950                 955                 960 


Asn Lys Ile Glu Phe Asn Glu Leu Asn Leu Leu Gln Ser Leu Leu Leu 
                965                 970                 975     


Lys Ile Leu His Arg Leu Val Gly Phe Thr Ser Ile Trp Glu Arg Asp 
            980                 985                 990         


Leu Arg Phe Arg Leu Thr Gly Glu  Phe Pro Asp Glu Leu  Asp Ile Glu 
        995                 1000                 1005             


Asp Ile  Phe Asp His Arg Lys  Arg Tyr Lys Gly Thr  Gly Gly Gly 
    1010                 1015                 1020             


Ile Cys  Lys Lys Tyr Asp Arg  Phe Ile Asn Thr Tyr  Thr Glu Tyr 
    1025                 1030                 1035             


Lys Asn  Asn Asn Lys Met Lys  Asn Val Lys Phe Ala  Asp Asn Asn 
    1040                 1045                 1050             


Pro Val  Arg Asn Tyr Ile Ala  His Phe Asn Tyr Leu  Pro Asn Pro 
    1055                 1060                 1065             


Lys Tyr  Ser Ile Leu Lys Met  Met Glu Lys Leu Arg  Lys Leu Leu 
    1070                 1075                 1080             


Asp Tyr  Asp Arg Lys Leu Lys  Asn Ala Val Met Lys  Ser Ile Lys 
    1085                 1090                 1095             


Asp Ile  Leu Glu Glu Tyr Gly  Phe Lys Ala Glu Phe  Ile Ile Asn 
    1100                 1105                 1110             


Ser Asp  Lys Glu Ile Ile Leu  Asn Pro Val Lys Ser  Val Glu Ile 
    1115                 1120                 1125             


Ile His  Leu Gly Lys Glu Asp  Leu Lys Ser Arg Arg  Asn Ser Glu 
    1130                 1135                 1140             


Asp Leu  Cys Lys Leu Val Lys  Ala Met Leu Glu Tyr  Ser Glu 
    1145                 1150                 1155         


<210>  1053
<211>  1066
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1053

Met Lys Val Thr Lys Val Gly Gly Ile Ser His Lys Lys Tyr Thr Ser 
1               5                   10                  15      


Glu Gly Arg Leu Val Lys Ser Glu Ser Glu Glu Asn Arg Thr Asp Glu 
            20                  25                  30          


Arg Leu Ser Ala Leu Leu Asn Met Arg Leu Asp Met Tyr Ile Lys Asn 
        35                  40                  45              


Pro Ser Ser Thr Glu Thr Lys Glu Asn Gln Lys Arg Ile Gly Lys Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Met Val Tyr Leu Lys Asp Asn Thr Leu 
65                  70                  75                  80  


Ser Leu Lys Asn Gly Lys Lys Glu Asn Ile Asp Arg Glu Tyr Ser Glu 
                85                  90                  95      


Thr Asp Ile Leu Glu Ser Asp Val Arg Asp Lys Lys Asn Phe Ala Val 
            100                 105                 110         


Leu Lys Lys Ile Tyr Leu Asn Glu Asn Val Asn Ser Glu Glu Leu Glu 
        115                 120                 125             


Val Phe Arg Asn Asp Ile Lys Lys Lys Leu Asn Lys Ile Asn Ser Leu 
    130                 135                 140                 


Lys Tyr Ser Phe Glu Lys Asn Lys Ala Asn Tyr Gln Lys Ile Asn Glu 
145                 150                 155                 160 


Asn Asn Ile Glu Lys Val Glu Gly Lys Ser Lys Arg Asn Ile Ile Tyr 
                165                 170                 175     


Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asp Ala Tyr Val Ser Asn Val 
            180                 185                 190         


Lys Glu Ala Phe Asp Lys Leu Tyr Lys Glu Glu Asp Ile Ala Lys Leu 
        195                 200                 205             


Val Leu Glu Ile Glu Asn Leu Thr Lys Leu Glu Lys Tyr Lys Ile Arg 
    210                 215                 220                 


Glu Phe Tyr His Glu Ile Ile Gly Arg Lys Asn Asp Lys Glu Asn Phe 
225                 230                 235                 240 


Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Met Lys Glu 
                245                 250                 255     


Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser Gln Val 
            260                 265                 270         


Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys Asn Ile 
        275                 280                 285             


Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln Leu Leu 
    290                 295                 300                 


Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp Lys Ile 
305                 310                 315                 320 


Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu Asn Lys 
                325                 330                 335     


Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys Tyr Asn 
            340                 345                 350         


Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile Ala Arg 
        355                 360                 365             


Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val Ser Ser 
    370                 375                 380                 


Val Ser Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn Glu Asn 
385                 390                 395                 400 


Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn Lys Gly 
                405                 410                 415     


Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Leu Tyr Asp Asn Asn 
            420                 425                 430         


Arg Gln Asn Glu Val Lys Lys Asn Leu Lys Met Phe Tyr Ser Tyr Asp 
        435                 440                 445             


Phe Asn Met Asp Ser Lys Asn Glu Ile Glu Asp Phe Phe Ser Asn Ile 
    450                 455                 460                 


Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe Asn Leu 
465                 470                 475                 480 


Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala Pro Ser 
                485                 490                 495     


Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys Lys Leu 
            500                 505                 510         


Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe Arg Tyr 
        515                 520                 525             


Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg Phe Glu 
    530                 535                 540                 


Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys Leu Tyr 
545                 550                 555                 560 


Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp Lys Thr 
                565                 570                 575     


Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp Ala Gln 
            580                 585                 590         


Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn Tyr Phe 
        595                 600                 605             


Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile Ile Glu 
    610                 615                 620                 


Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr Lys Leu 
625                 630                 635                 640 


Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr Leu Ala 
                645                 650                 655     


Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp Glu Glu 
            660                 665                 670         


Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu Lys Gly 
        675                 680                 685             


Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile Tyr Ile 
    690                 695                 700                 


Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys Gln Glu 
705                 710                 715                 720 


Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile Lys Ile 
                725                 730                 735     


Pro Tyr Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly Asn Ile 
            740                 745                 750         


Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu Lys Leu 
        755                 760                 765             


Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu Lys Tyr 
    770                 775                 780                 


Gln Ser Ala Asn Lys Glu Glu Ala Phe Ser Asp Gln Leu Glu Leu Ile 
785                 790                 795                 800 


Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe Glu Leu 
                805                 810                 815     


Glu Val Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn Lys Ile 
            820                 825                 830         


Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile Tyr Phe 
        835                 840                 845             


Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile Lys Lys 
    850                 855                 860                 


Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala Lys Tyr 
865                 870                 875                 880 


Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys Asn Glu 
                885                 890                 895     


Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys Tyr Ala 
            900                 905                 910         


Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Lys Lys Tyr 
        915                 920                 925             


Glu Lys Ala Ile Arg Asn Ile Gln Gln Tyr Thr His Leu Lys Asn Lys 
    930                 935                 940                 


Val Glu Ala Gly Thr Asp Phe Leu Ala Ser Gln Met Phe Phe Asp Asn 
945                 950                 955                 960 


Asp Val Phe Val Lys Phe Lys Glu Gln Ala Glu Lys Leu Asp Ile Glu 
                965                 970                 975     


Val Pro Leu Ile Ala Gly Ile Met Pro Val Thr Asn Ala Lys Gln Ile 
            980                 985                 990         


Lys Arg Ile Ile Glu Leu Ser Lys  Cys Ser Val Pro Glu  Lys Leu Asp 
        995                 1000                 1005             


Lys Leu  Leu Glu Lys Tyr Gly  Asp Asn Pro Glu Ser  Met Lys Lys 
    1010                 1015                 1020             


Ala Gly  Ile Met Tyr Ala Ser  Glu Gln Ile Ile Glu  Leu Leu Ala 
    1025                 1030                 1035             


Tyr Gly  Ile Lys Gly Ile His  Ile Tyr Thr Met Asn  Lys Pro Glu 
    1040                 1045                 1050             


Ile Ala  Lys Glu Ile Met Lys  Asn Ile Glu Phe Ala  Arg 
    1055                 1060                 1065     


<210>  1054
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1054

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Asp Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn Tyr Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Gly Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Gly Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Lys Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Arg Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Asp Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  1055
<211>  1185
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1055

Met Arg Ile Ile Lys Pro Tyr Gly Arg Ser Val Val Glu Lys Ala Gly 
1               5                   10                  15      


Pro Gly Arg Leu Ala Arg Ala Val Ser Leu His Pro Asp Pro Ala Arg 
            20                  25                  30          


Gly Val Glu Leu Asp Asn Arg Lys Ser Val Val Glu Phe Ala Ala Ser 
        35                  40                  45              


His Asp Arg Leu Val Ile Ala Gln Trp Ile Ser Thr Ile Asp Lys Ile 
    50                  55                  60                  


Ala Arg Lys Pro Val Gly Glu Ala Ala Ala Thr Pro Gln Gln Ala Glu 
65                  70                  75                  80  


Phe Arg Arg Arg Leu Gly Asp Ala Ala Trp Thr Leu Ile Glu Arg Arg 
                85                  90                  95      


Ala Leu Leu Thr Gly Leu Asn Asp Pro Ala Val Lys Ala Arg Leu Arg 
            100                 105                 110         


Arg Leu Trp Glu Phe Lys Ile Ala Pro Tyr Lys Thr Ala Arg Ala Val 
        115                 120                 125             


Ala Lys Thr Gly Thr Arg Pro Pro Arg Leu Lys Gly Trp Trp Phe Arg 
    130                 135                 140                 


Arg Phe Ala Gly Asp Val Glu Glu Val Asp Lys Val Asp Ala Asp Ala 
145                 150                 155                 160 


Val Ala Leu Ala Ile His Glu His Leu Tyr Ser Ala Gln Tyr Gln Met 
                165                 170                 175     


Arg Val Asp Asp Arg Thr Arg Leu Ser Gly Leu Ile Ala Ala Arg Ala 
            180                 185                 190         


Glu Ser Ile Ala Gly Asn Val Leu Gln Pro His Ala Ala Ala Arg Asp 
        195                 200                 205             


Lys Asp Gly Gly Trp Ser Glu Asp Asp Gln Arg Arg Tyr Ala Ala Ala 
    210                 215                 220                 


Gly Asp Val Ala Arg Glu Ile Arg Ser Ala Ala Glu Ala Arg Glu Arg 
225                 230                 235                 240 


Gly Asp Gly Lys Ile Gly Pro Arg Arg Val Thr Ser Glu Val Ala Gly 
                245                 250                 255     


Ala Ala Leu Phe Glu His Tyr Ala Arg Leu Phe Arg Gly Ala Asp Gly 
            260                 265                 270         


Lys Ala Met Gly Val Ala Gln Ala Arg Asp Gln Glu Ser Gly Leu Phe 
        275                 280                 285             


Asn Leu His Met Ala Val Lys Asp Cys Tyr Ala Arg Ile Leu Lys Gly 
    290                 295                 300                 


His Gly Lys Asp Leu Ala Lys His Gly Glu Gly Arg Arg Arg Val Ser 
305                 310                 315                 320 


Thr Leu Leu Pro Pro Thr Ser Val Asp Leu Phe Arg Leu Leu Asp Ala 
                325                 330                 335     


Met Leu Asp Asn Arg Asp Leu Asn Ala Leu Val Arg Leu Gly Lys Val 
            340                 345                 350         


Ile His Tyr Glu Ser Ala Gly Ala Gly Val Asp Arg Pro Ala Asp Val 
        355                 360                 365             


Val Asp His Trp Pro Ala Asp Val Ala Asp Ser Asp Tyr Trp Thr Ser 
    370                 375                 380                 


Asp Gly Gln Ala Arg Ile Lys Arg Asn Glu Ala Leu Val Arg Val Trp 
385                 390                 395                 400 


Arg His Val Leu Ala Leu Ala Ser Arg Thr Leu Thr Asp Trp Ala Asp 
                405                 410                 415     


Pro Lys Gly Met Ile Gly Gly Asp Ile Leu Leu Lys Asp Ser Val Glu 
            420                 425                 430         


Thr Ala Ile Ala Asn Phe Asp Ala Glu Ser Tyr Lys Arg Lys Ile Glu 
        435                 440                 445             


Val Leu Phe Gly Gly Arg Ala Ala Leu Phe Asp Gly Asp Gly Asp Glu 
    450                 455                 460                 


Ala Phe Glu Lys Asp Val Leu Arg Phe Ala Leu His Gly Val Ala Ala 
465                 470                 475                 480 


Leu Arg Asn Ala Ala Phe His Phe Lys Gly Val Gly Gly Phe Ala Glu 
                485                 490                 495     


Ala Leu Lys Thr Leu Gly Pro Arg Gln Asp Pro Arg Val Thr Ala Ala 
            500                 505                 510         


Val Asp Gly Leu Trp Arg Thr Asp Glu Glu Gly Arg Gly Arg Arg Leu 
        515                 520                 525             


Leu Ala Thr Met Arg Gly Ala His Phe Glu Ser Phe Phe Asp Gln Arg 
    530                 535                 540                 


Gln Asn Arg Arg Leu Ala Gln Ala Leu Ser Arg Ala Ser Glu Glu Ser 
545                 550                 555                 560 


Leu Pro Leu Pro Arg Phe Ala Val Met Leu Arg Arg Ala Glu Asn Ala 
                565                 570                 575     


Trp Asp Arg Leu Gly Leu Pro Lys Thr Ala Asn Arg Ala Asp Leu Glu 
            580                 585                 590         


Ala Pro Ala Arg His Cys Gln Tyr Val Ala Leu Lys Leu Leu Tyr Glu 
        595                 600                 605             


Arg Pro Phe Arg Ala Trp Leu Ala Glu Arg Asp Ala Ala Thr Leu Asn 
    610                 615                 620                 


Arg Phe Ile Val Cys Ala Val Glu Arg Ala Thr Lys Ala Ala Arg Met 
625                 630                 635                 640 


Leu Asn Pro Gly Ala Ser Arg Glu Leu Ala Glu Ala Ile Thr Ala Lys 
                645                 650                 655     


Ala Ala Asp Leu Gly Arg Leu Gly Asn Asp Asp Ser Val Glu Asp Phe 
            660                 665                 670         


Phe Phe Arg Leu Ser Ala Glu Thr Ala Gly Glu Ala Arg Val Gln Arg 
        675                 680                 685             


Gly Tyr Glu Ser Asp Ala Glu Asn Ala Arg Ala Gln Ala Ser His Ile 
    690                 695                 700                 


Glu Asn Leu Lys Ala Asp Leu Val Ala Leu Ala Phe Arg Asp Tyr Leu 
705                 710                 715                 720 


Gln Lys Ala Asp Phe Glu Phe Ala Leu Lys Leu Arg Gly Asp Glu Pro 
                725                 730                 735     


Leu Pro Thr Lys Pro Met Cys Ala Leu Asp Glu Ala Asp Phe Val Glu 
            740                 745                 750         


Gly Glu Ala Ser Ser Ala Glu Pro Pro Cys Glu Leu Tyr Phe Leu Leu 
        755                 760                 765             


His Leu Val Pro Val Asp Glu Val Gly Lys Leu Leu His Gln Leu Arg 
    770                 775                 780                 


Lys Trp Gln Ile Leu Ala Pro Pro Ala Pro Ala Ala Thr Gly Gly Pro 
785                 790                 795                 800 


Thr Thr Ala Ala Thr Val Ala Glu Ile Arg Leu Ala Leu Glu Leu Tyr 
                805                 810                 815     


Leu Asp Met His Asp Ala Lys Phe Glu Gly Gly Ala Ala Leu Val Gly 
            820                 825                 830         


Val Glu Pro Phe Lys Arg Leu Phe Glu Gly Asp Gly Leu Phe Gly Arg 
        835                 840                 845             


Ile Phe Glu Arg Pro Ala Gly Asp Arg Pro Gly Ala Glu Asp Asp Arg 
    850                 855                 860                 


Arg Leu Pro Arg Arg Gly Leu Arg Glu Ile Met Arg Phe Gly His Leu 
865                 870                 875                 880 


Arg Pro Leu Leu Pro Ile Phe Asp Lys Gln Pro Ile Arg Ala Asp Glu 
                885                 890                 895     


Val Ala Ala Tyr Leu Asp Ala Glu Gln Val Pro Asp Gly Gly Lys Ser 
            900                 905                 910         


Glu Ile Ala Arg Arg Gln Glu Arg Arg Glu Ala Leu His Glu Lys Trp 
        915                 920                 925             


Ala Arg Arg Arg Arg Glu Phe Ser Asp Asp Asp Arg Arg Ala Tyr Glu 
    930                 935                 940                 


Glu Ala Leu Arg Phe Val Glu Glu His Arg His Arg Ala Ala Arg Val 
945                 950                 955                 960 


Thr Leu Thr Asp His Val Arg Leu His Arg Leu Leu Met Ala Val Leu 
                965                 970                 975     


Gly Arg Leu Val Asp Tyr Ser Gly Leu Trp Glu Arg Asp Leu Tyr Phe 
            980                 985                 990         


Val Ala Leu Ala Leu Ile His Gln  Ala Gly Arg Arg Leu  Asp Glu Ile 
        995                 1000                 1005             


Phe Ala  Ala Asp Gly Leu Ala  Met Leu Arg Glu Gly  Arg Val Val 
    1010                 1015                 1020             


Glu Ala  Leu Arg Lys Leu Ala  Asp Ile Asp Ala Ala  Arg Ala Ile 
    1025                 1030                 1035             


Ala Ala  Glu Val Lys Arg Arg  Phe Asp Gly Ala Pro  Asp Ala Ala 
    1040                 1045                 1050             


Ser Arg  Val Val Lys Ile Arg  Asn Ala Phe Ala His  Phe Asn Met 
    1055                 1060                 1065             


Leu Arg  Pro Lys Arg Gly Gly  Ala Thr Ala Ala Leu  Asp Leu Thr 
    1070                 1075                 1080             


Ala Ala  Val Asn Asp Gly Arg  Glu Leu Met Ala Tyr  Asp Arg Lys 
    1085                 1090                 1095             


Leu Lys  Asn Ala Val Ser Arg  Ser Ile Ala Glu Leu  Leu Glu Arg 
    1100                 1105                 1110             


Glu Gly  Leu Ala Val Ala Trp  Ser Val Asn Glu His  Arg Leu Glu 
    1115                 1120                 1125             


Ala Thr  Arg Val Ser Thr Arg  Gln Ala Ser His Leu  Ala Asn Ser 
    1130                 1135                 1140             


Gly Leu  Arg Glu Asp Leu His  Gly Ala Gly Tyr Val  Ala Thr Val 
    1145                 1150                 1155             


Ala Glu  Leu Phe Gly Arg Thr  Ala Ala Lys Pro Ala  Ala Pro Leu 
    1160                 1165                 1170             


Ala Arg  Arg Glu Asn Arg Thr  Ala Arg Gly Gly Arg  
    1175                 1180                 1185 


<210>  1056
<211>  1276
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1056

Met Lys Ile Ser Lys Val Asp His Val Lys Ser Gly Ile Asp Gln Lys 
1               5                   10                  15      


Leu Ser Ser Gln Arg Gly Met Leu Tyr Lys Gln Pro Gln Lys Lys Tyr 
            20                  25                  30          


Glu Gly Lys Gln Leu Glu Glu His Val Arg Asn Leu Ser Arg Lys Ala 
        35                  40                  45              


Lys Ala Leu Tyr Gln Val Phe Pro Val Ser Gly Asn Ser Lys Met Glu 
    50                  55                  60                  


Lys Glu Leu Gln Ile Ile Asn Ser Phe Ile Lys Asn Ile Leu Leu Arg 
65                  70                  75                  80  


Leu Asp Ser Gly Lys Thr Ser Glu Glu Ile Val Gly Tyr Ile Asn Thr 
                85                  90                  95      


Tyr Ser Val Ala Ser Gln Ile Ser Gly Asp His Ile Gln Glu Leu Val 
            100                 105                 110         


Asp Gln His Leu Lys Glu Ser Leu Arg Lys Tyr Thr Cys Val Gly Asp 
        115                 120                 125             


Lys Arg Ile Tyr Val Pro Asp Ile Ile Val Ala Leu Leu Lys Ser Lys 
    130                 135                 140                 


Phe Asn Ser Glu Thr Leu Gln Tyr Asp His Ser Glu Leu Lys Ile Leu 
145                 150                 155                 160 


Ile Asp Phe Ile Arg Glu Asp Tyr Leu Lys Glu Lys Gln Ile Lys Gln 
                165                 170                 175     


Ile Val His Ser Ile Glu Asn Asn Ser Thr Pro Leu Arg Ile Ala Glu 
            180                 185                 190         


Ile Asn Gly Gln Lys Arg Leu Ile Pro Ala Asn Val Asp Asn Pro Lys 
        195                 200                 205             


Lys Ser Tyr Ile Phe Glu Phe Leu Lys Glu Tyr Ala Gln Ser Asp Pro 
    210                 215                 220                 


Lys Gly Gln Glu Ser Leu Leu Gln His Met Arg Tyr Leu Ile Leu Leu 
225                 230                 235                 240 


Tyr Leu Tyr Gly Pro Asp Lys Ile Thr Asp Asp Tyr Cys Glu Glu Ile 
                245                 250                 255     


Glu Ala Trp Asn Phe Gly Ser Ile Val Met Asp Asn Glu Gln Leu Phe 
            260                 265                 270         


Ser Glu Glu Ala Ser Met Leu Ile Gln Asp Arg Ile Tyr Val Asn Gln 
        275                 280                 285             


Gln Ile Glu Glu Gly Arg Gln Ser Lys Asp Thr Ala Lys Val Lys Lys 
    290                 295                 300                 


Asn Lys Ser Lys Tyr Arg Met Leu Gly Asp Lys Ile Glu His Ser Ile 
305                 310                 315                 320 


Asn Glu Ser Val Val Lys His Tyr Gln Glu Ala Cys Lys Ala Val Glu 
                325                 330                 335     


Glu Lys Asp Ile Pro Trp Ile Lys Tyr Ile Ser Asp His Val Met Ser 
            340                 345                 350         


Val Tyr Ser Ser Lys Asn Arg Val Asp Leu Asp Lys Leu Ser Leu Pro 
        355                 360                 365             


Tyr Leu Ala Lys Asn Thr Trp Asn Thr Trp Ile Ser Phe Ile Ala Met 
    370                 375                 380                 


Lys Tyr Val Asp Met Gly Lys Gly Val Tyr His Phe Ala Met Ser Asp 
385                 390                 395                 400 


Val Asp Lys Val Gly Lys Gln Asp Asn Leu Ile Ile Gly Gln Ile Asp 
                405                 410                 415     


Pro Lys Phe Ser Asp Gly Ile Ser Ser Phe Asp Tyr Glu Arg Ile Lys 
            420                 425                 430         


Ala Glu Asp Asp Leu His Arg Ser Met Ser Gly Tyr Ile Ala Phe Ala 
        435                 440                 445             


Val Asn Asn Phe Ala Arg Ala Ile Cys Ser Asp Glu Phe Arg Lys Lys 
    450                 455                 460                 


Asn Arg Lys Glu Asp Val Leu Thr Val Gly Leu Asp Glu Ile Pro Leu 
465                 470                 475                 480 


Tyr Asp Asn Val Lys Arg Lys Leu Leu Gln Tyr Phe Gly Gly Ala Ser 
                485                 490                 495     


Asn Trp Asp Asp Ser Ile Ile Asp Ile Ile Asp Asp Lys Asp Leu Val 
            500                 505                 510         


Ala Cys Ile Lys Glu Asn Leu Tyr Val Ala Arg Asn Val Asn Phe His 
        515                 520                 525             


Phe Ala Gly Ser Glu Lys Val Gln Lys Lys Gln Asp Asp Ile Leu Glu 
    530                 535                 540                 


Glu Ile Val Arg Lys Glu Thr Arg Asp Ile Gly Lys His Tyr Arg Lys 
545                 550                 555                 560 


Val Phe Tyr Ser Asn Asn Val Ala Val Phe Tyr Cys Asp Glu Asp Ile 
                565                 570                 575     


Ile Lys Leu Met Asn His Leu Tyr Gln Arg Glu Lys Pro Tyr Gln Ala 
            580                 585                 590         


Gln Ile Pro Ser Tyr Asn Lys Val Ile Ser Lys Thr Tyr Leu Pro Asp 
        595                 600                 605             


Leu Ile Phe Met Leu Leu Lys Gly Lys Asn Arg Thr Lys Ile Ser Asp 
    610                 615                 620                 


Pro Ser Ile Met Asn Met Phe Arg Gly Thr Phe Tyr Phe Leu Leu Lys 
625                 630                 635                 640 


Glu Ile Tyr Tyr Asn Asp Phe Leu Gln Ala Ser Asn Leu Lys Glu Met 
                645                 650                 655     


Phe Cys Glu Gly Leu Lys Asn Asn Val Lys Asn Lys Lys Ser Glu Lys 
            660                 665                 670         


Pro Tyr Gln Asn Phe Met Arg Arg Phe Glu Glu Leu Glu Asn Met Gly 
        675                 680                 685             


Met Asp Phe Gly Glu Ile Cys Gln Gln Ile Met Thr Asp Tyr Glu Gln 
    690                 695                 700                 


Gln Asn Lys Gln Lys Lys Lys Thr Ala Thr Ala Val Met Ser Glu Lys 
705                 710                 715                 720 


Asp Lys Lys Ile Arg Thr Leu Asp Asn Asp Thr Gln Lys Tyr Lys His 
                725                 730                 735     


Phe Arg Thr Leu Leu Tyr Ile Gly Leu Arg Glu Ala Phe Ile Ile Tyr 
            740                 745                 750         


Leu Lys Asp Glu Lys Asn Lys Glu Trp Tyr Glu Phe Leu Arg Glu Pro 
        755                 760                 765             


Val Lys Arg Glu Gln Pro Glu Glu Lys Glu Phe Val Asn Lys Trp Lys 
    770                 775                 780                 


Leu Asn Gln Tyr Ser Asp Cys Ser Glu Leu Ile Leu Lys Asp Ser Leu 
785                 790                 795                 800 


Ala Ala Ala Trp Tyr Val Val Ala His Phe Ile Asn Gln Ala Gln Leu 
                805                 810                 815     


Asn His Leu Ile Gly Asp Ile Lys Asn Tyr Ile Gln Phe Ile Ser Asp 
            820                 825                 830         


Ile Asp Arg Arg Ala Lys Ser Thr Gly Asn Pro Val Ser Glu Ser Thr 
        835                 840                 845             


Glu Ile Gln Ile Glu Arg Tyr Arg Lys Ile Leu Arg Val Leu Glu Phe 
    850                 855                 860                 


Ala Lys Phe Phe Cys Gly Gln Ile Thr Asn Val Leu Thr Asp Tyr Tyr 
865                 870                 875                 880 


Gln Asp Glu Asn Asp Phe Ser Thr His Val Gly His Tyr Val Lys Phe 
                885                 890                 895     


Glu Lys Lys Asn Met Glu Pro Ala His Ala Leu Gln Ala Phe Ser Asn 
            900                 905                 910         


Ser Leu Tyr Ala Cys Gly Lys Glu Lys Lys Lys Ala Gly Phe Tyr Tyr 
        915                 920                 925             


Asp Gly Met Asn Pro Ile Val Asn Arg Asn Ile Thr Leu Ala Ser Met 
    930                 935                 940                 


Tyr Gly Asn Lys Lys Leu Leu Glu Asn Ala Met Asn Pro Val Thr Glu 
945                 950                 955                 960 


Gln Asp Ile Arg Lys Tyr Tyr Ser Leu Met Ala Glu Leu Asp Ser Val 
                965                 970                 975     


Leu Lys Asn Gly Ala Val Cys Lys Ser Glu Asp Glu Gln Lys Asn Leu 
            980                 985                 990         


Arg His Phe Gln Asn Leu Lys Asn  Arg Ile Glu Leu Val  Asp Val Leu 
        995                 1000                 1005             


Thr Leu  Ser Glu Leu Val Asn  Asp Leu Val Ala Gln  Leu Ile Gly 
    1010                 1015                 1020             


Trp Val  Tyr Ile Arg Glu Arg  Asp Met Met Tyr Leu  Gln Leu Gly 
    1025                 1030                 1035             


Leu His  Tyr Ile Lys Leu Tyr  Phe Thr Asp Ser Val  Ala Glu Asp 
    1040                 1045                 1050             


Ser Tyr  Leu Arg Thr Leu Asp  Leu Glu Glu Gly Ser  Ile Ala Asp 
    1055                 1060                 1065             


Gly Ala  Val Leu Tyr Gln Ile  Ala Ser Leu Tyr Ser  Phe Asn Leu 
    1070                 1075                 1080             


Pro Met  Tyr Val Lys Pro Asn  Lys Ser Ser Val Tyr  Cys Lys Lys 
    1085                 1090                 1095             


His Val  Asn Ser Val Ala Thr  Lys Phe Asp Ile Phe  Glu Lys Glu 
    1100                 1105                 1110             


Tyr Cys  Asn Gly Asp Glu Thr  Val Ile Glu Asn Gly  Leu Arg Leu 
    1115                 1120                 1125             


Phe Glu  Asn Ile Asn Leu His  Lys Asp Met Val Lys  Phe Arg Asp 
    1130                 1135                 1140             


Tyr Leu  Ala His Phe Lys Tyr  Phe Ala Lys Leu Asp  Glu Ser Ile 
    1145                 1150                 1155             


Leu Glu  Leu Tyr Ser Lys Ala  Tyr Asp Phe Phe Phe  Ser Tyr Asn 
    1160                 1165                 1170             


Ile Lys  Leu Lys Lys Ser Val  Ser Tyr Val Leu Thr  Asn Val Leu 
    1175                 1180                 1185             


Leu Ser  Tyr Phe Ile Asn Ala  Lys Leu Ser Phe Ser  Thr Tyr Lys 
    1190                 1195                 1200             


Ser Ser  Gly Asn Lys Thr Val  Gln His Arg Thr Thr  Lys Ile Ser 
    1205                 1210                 1215             


Val Val  Ala Gln Thr Asp Tyr  Phe Thr Tyr Lys Leu  Arg Ser Ile 
    1220                 1225                 1230             


Val Lys  Asn Lys Asn Gly Val  Glu Ser Ile Glu Asn  Asp Asp Cys 
    1235                 1240                 1245             


Arg Cys  Glu Val Val Asn Ile  Ala Ala Arg Asp Lys  Glu Phe Val 
    1250                 1255                 1260             


Asp Glu  Val Cys Asn Val Ile  Asn Tyr Asn Ser Asp  Lys 
    1265                 1270                 1275     


<210>  1057
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1057

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  1058
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1058

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  1059
<211>  1143
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1059

Met Arg Val Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Val Tyr Ser Gly 
            20                  25                  30          


Gln Pro Val Ser Asn Glu Thr Cys Asn Ile Leu Pro Glu Lys Lys Arg 
        35                  40                  45              


Gln Ser Phe Asp Leu Ser Ile Glu Asn Lys Thr Leu Lys Arg Arg Asp 
    50                  55                  60                  


Asp Val Asp Lys Thr Lys Lys Gly Lys Tyr Asp Ile Val Arg Lys Ile 
65                  70                  75                  80  


Ile Lys Tyr Gly Glu Leu Pro Gln Ser Ile Asn Asp Val Asp Ile Leu 
                85                  90                  95      


Glu Phe Leu Asn His Lys Phe Gln Lys Pro Val Lys Tyr Trp Lys Asn 
            100                 105                 110         


Gly Lys Glu Glu Ser Phe Asn Leu Thr Leu Leu Ile Val Glu Ala Val 
        115                 120                 125             


Lys Thr Gln Asp Arg Gln Lys Leu Gln Pro Tyr Tyr Asp Trp Lys Thr 
    130                 135                 140                 


Trp Tyr Ile Gln Thr Lys Ser Asp Leu Leu Lys Lys Ser Ile Glu Asn 
145                 150                 155                 160 


Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg Lys Lys Ala Leu 
                165                 170                 175     


Leu Ala Trp Glu Thr Glu Phe Thr Thr Ser Gly Lys Ile Asp Leu Thr 
            180                 185                 190         


His Tyr His Lys Val Tyr Met Thr Asp Val Leu Cys Thr Ala Leu Gln 
        195                 200                 205             


Lys Val Glu Pro Ser Thr Asp Lys Lys Gly Lys Ile Asn Thr Asn Ala 
    210                 215                 220                 


Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Thr His Gln Pro Ala Ile 
225                 230                 235                 240 


Phe Gly Thr Arg Gln Ala Pro Asn Asn Val Asn Arg Ala Asp Asp Arg 
                245                 250                 255     


Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu Glu His Tyr Phe 
            260                 265                 270         


Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Ala Asp Asp Ile Glu His 
        275                 280                 285             


Tyr Leu Lys Thr Gln Thr Leu Lys Thr Thr Ile Glu Lys Gln Leu Val 
    290                 295                 300                 


Asn Ala Ile Arg Ala Asn Ile Ile Gln Gln Gly Lys Thr Asn His His 
305                 310                 315                 320 


Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile Arg Ile Lys Thr 
                325                 330                 335     


Asn Glu Ala Phe Val Leu Asn Leu Thr Gly Thr Cys Ala Phe Ala Ala 
            340                 345                 350         


Asn Asn Ile Arg Asn Met Val Asp Asn Glu Gln Thr Asn Asp Ile Leu 
        355                 360                 365             


Gly Lys Gly Asp Phe Ile Lys Ser Leu Leu Lys Asp Asn Thr Asn Gly 
    370                 375                 380                 


Gln Leu Tyr Ser Phe Phe Phe Gly Glu Ser Leu Ser Thr Asn Lys Ala 
385                 390                 395                 400 


Glu Lys Glu Thr Gln Leu Trp Gly Ile Arg Gly Ala Val Gln Gln Ile 
                405                 410                 415     


Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu Lys Thr Val Phe 
            420                 425                 430         


Asn Ile Ser Asn Phe Glu Asn Pro Thr Ile Thr Asp Pro Lys Gln Gln 
        435                 440                 445             


Thr Asn Tyr Ala Asp Thr Ile Tyr Lys Ala Leu Phe Ile Lys Glu Leu 
    450                 455                 460                 


Glu Lys Ile Pro Asn Ala Phe Ala Gln Gln Leu Lys Thr Gly Gly Ala 
465                 470                 475                 480 


Leu Ser Tyr Tyr Thr Ile Glu Asn Leu Lys Ser Leu Leu Thr Thr Phe 
                485                 490                 495     


Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala Pro Gly Phe Lys 
            500                 505                 510         


Lys Val Phe Asn Gly Gly Ile Asn Tyr Gln Asn Ala Lys Gln Asp Glu 
        515                 520                 525             


Ser Phe Tyr Glu Leu Met Leu Glu Arg Tyr Leu Arg Lys Glu Asn Phe 
    530                 535                 540                 


Ala Glu Glu Ala Tyr Asn Ala Arg Tyr Phe Leu Leu Lys Leu Ile Tyr 
545                 550                 555                 560 


Asn Asn Leu Phe Leu Pro Gly Phe Thr Arg Asp Arg Lys Ala Phe Ala 
                565                 570                 575     


Asp Ser Val Gly Phe Val Gln Met Gln Asn Lys Lys Gln Ala Glu Lys 
            580                 585                 590         


Val Asn Pro Lys Lys Arg Glu Ala Tyr Ala Phe Glu Ala Val Arg Pro 
        595                 600                 605             


Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala Tyr Val Gln Ser 
    610                 615                 620                 


Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys Ala Thr Asp Glu 
625                 630                 635                 640 


Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val Phe Val Lys Gly 
                645                 650                 655     


Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe Val Gln Val Pro 
            660                 665                 670         


Gln Pro Gln Leu Thr Ala Thr Ala Ser Asn Gln Gln Lys Ala Asp Lys 
        675                 680                 685             


Leu Asn Gln Leu Glu Ala Ser Ile Thr Ala Asp Cys Lys Leu Thr Pro 
    690                 695                 700                 


Gln Tyr Ala Lys Ala Asp Asn Ala Thr His Ile Ala Phe Tyr Val Phe 
705                 710                 715                 720 


Cys Lys Leu Leu Asp Ala Gly His Leu Ser Asn Leu Arg Asn Glu Leu 
                725                 730                 735     


Ile Lys Phe Arg Glu Ser Val Asn Glu Phe Lys Phe His His Leu Leu 
            740                 745                 750         


Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val Val Pro Thr Asp 
        755                 760                 765             


Tyr Arg Asp Leu Tyr Ser Ser Glu Ala Asp Cys Leu Ala Arg Leu Arg 
    770                 775                 780                 


Pro Phe Ile Glu Gln Gly Ala Asp Ile Thr Asn Trp Ser Asp Leu Phe 
785                 790                 795                 800 


Val Gln Ser Asp Lys His Ser Pro Val Ile His Ala Asn Ile Glu Leu 
                805                 810                 815     


Ser Val Lys Tyr Gly Thr Thr Lys Leu Leu Glu Gln Ile Ile Asn Lys 
            820                 825                 830         


Asp Pro Gln Phe Lys Thr Thr Glu Ala Asn Phe Thr Ala Trp Asn Thr 
        835                 840                 845             


Ala Gln Lys Ser Ile Glu Gln Leu Ile Lys Gln Arg Glu Asp His His 
    850                 855                 860                 


Glu Gln Trp Val Lys Ala Lys Asn Ala Asp Asp Lys Glu Lys Gln Glu 
865                 870                 875                 880 


Arg Lys Arg Glu Lys Ser Asn Phe Ala Gln Lys Phe Ile Glu Lys His 
                885                 890                 895     


Gly Asp Asp Tyr Leu Asp Ile Cys Asp Tyr Ile Asn Thr Tyr Asn Trp 
            900                 905                 910         


Leu Asp Asn Lys Met His Phe Val His Leu Asn Arg Leu His Gly Leu 
        915                 920                 925             


Thr Ile Glu Leu Leu Gly Arg Met Ala Gly Phe Val Ala Leu Phe Asp 
    930                 935                 940                 


Arg Asp Phe Gln Met Leu Asp Ala Lys Arg Ile Ser Asp Leu Tyr Gln 
945                 950                 955                 960 


Leu Lys Ser Phe Ile Ser Phe Arg Glu Ile Thr Ser Glu Leu Asp Lys 
                965                 970                 975     


Asn Asn Asp Ile Thr Glu Ile Asn Leu Ile Lys Asp Lys Glu Ile Ile 
            980                 985                 990         


Lys Arg Asp Gly Thr Pro Ile Thr  Glu Ala Asp Arg Asn  Ser Leu Lys 
        995                 1000                 1005             


Ser Cys  Ile Gln Ser Lys Arg  Glu Tyr Tyr Gln Lys  Thr Tyr Phe 
    1010                 1015                 1020             


Lys Glu  His Thr Asn Pro Phe  Thr Asp Arg Asn Tyr  Ile Ala His 
    1025                 1030                 1035             


Phe Asn  Tyr Leu Ser Thr Asn  Thr Gly Asn His Ser  Leu Ile Lys 
    1040                 1045                 1050             


Leu Ile  Asn Lys Leu Arg Asp  Leu Leu His Tyr Asp  Arg Lys Leu 
    1055                 1060                 1065             


Lys Asn  Ala Val Ser Lys Ala  Phe Ile Asp Leu Phe  Asp Lys His 
    1070                 1075                 1080             


Gly Met  Ile Leu Lys Leu Lys  Leu Asn Thr Asp His  Gln Leu Glu 
    1085                 1090                 1095             


Val Glu  Ser Leu Glu Pro Lys  Lys Ile Tyr His Leu  Gly Ser Ser 
    1100                 1105                 1110             


Ala Lys  Asp Lys Pro Glu Tyr  Gln Tyr Cys Thr Asn  Gln Val Met 
    1115                 1120                 1125             


Met Ala  Tyr Cys Asn Met Cys  Arg Ser Leu Leu Glu  Met Lys Lys 
    1130                 1135                 1140             


<210>  1060
<211>  1391
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1060

Met Lys Ile Ser Lys Glu Gly His Lys Arg Met Ser Val Thr Leu Lys 
1               5                   10                  15      


Asn Glu Glu Val Gln Lys Asn Ala Ala Asp Lys Ala Glu Gly Gln Ile 
            20                  25                  30          


Leu Pro Leu Glu Lys Gly Gln Lys Leu Lys Thr Tyr Ile Gln Lys Arg 
        35                  40                  45              


Val Asp Ser Ser Lys Arg Leu Tyr Lys Val Leu Gly Pro Ser Ala Val 
    50                  55                  60                  


Ser Lys Leu Asn Val Ala Lys Ser Glu Ala Val Leu Lys Cys Phe Asn 
65                  70                  75                  80  


Asp Phe Met Lys Asn Ile Ile Asp Asn Asn Val Arg Val Lys Pro Ala 
                85                  90                  95      


Asp Lys Arg Asp Arg Thr Ala Val Asp Tyr Ile Gln Asn Arg Gly Phe 
            100                 105                 110         


Ser Ile Glu Val Arg Asp Gly Thr Lys Glu Asp Lys Ser Asn Glu Asn 
        115                 120                 125             


Arg Gly Lys Lys Lys Glu Gln Lys Glu Ile Lys Lys Pro Leu Ser Asp 
    130                 135                 140                 


Val Tyr Ile Asp Val Asp Glu Ala Phe Val His Glu Leu Thr Arg Leu 
145                 150                 155                 160 


His Leu Arg Gly Thr Leu Lys Lys Lys Ala Lys Ile Glu Lys Asp Gly 
                165                 170                 175     


Thr Gln Val Asp Ile Tyr Ile Pro Asp Ile Ile Glu Lys Leu Val Phe 
            180                 185                 190         


Ala Thr Thr His Gly Ser Gln Phe Asp Ser Leu Ile Ser Gln Ile Gly 
        195                 200                 205             


Glu Ala Glu Leu Thr Ala Cys Ile His Ile Ile Phe Met Asp Tyr Thr 
    210                 215                 220                 


Lys Glu Glu Gln Ile Lys Lys Ile Ala Lys Ser Ile Glu Asn Gln Asp 
225                 230                 235                 240 


Val Lys Val Gln Val Leu Gly Lys Gly Lys Asp Ala Arg Leu Gln Leu 
                245                 250                 255     


Ala Ser Ala Asp Asn Glu Lys Lys Lys Tyr Ile Phe Leu Phe Leu Glu 
            260                 265                 270         


Lys Phe Ala Cys Ala Ala Ser Glu Glu Glu Arg Asp Asn Leu Leu Arg 
        275                 280                 285             


Glu Phe Arg Glu Leu Ile Val Leu Phe Tyr Cys Gly Thr Val Pro Tyr 
    290                 295                 300                 


Glu Glu Ile Lys Glu Arg Lys Thr Arg Ile Pro Val Trp Asp Phe Ser 
305                 310                 315                 320 


Phe Leu Ser Lys Met Val Ser Asp Val Pro Leu Ser Phe Ser Gln Glu 
                325                 330                 335     


Cys Ser Glu Lys Leu Ala Glu Arg Glu Leu Leu Lys Ala Glu Thr Asp 
            340                 345                 350         


Leu Glu Arg Arg Lys Glu Asn Lys Leu Lys Ile Arg Asp Ile Asn Thr 
        355                 360                 365             


Glu Val Lys Arg Asn Leu Glu Arg Ile Val Ala Gln Arg Tyr Gln Glu 
    370                 375                 380                 


Gly Ile Lys Ile Leu Gly Asp Val Ser Gly Glu Glu Tyr Lys Glu Lys 
385                 390                 395                 400 


Arg Phe Trp Leu Glu Tyr Ile Glu Asn Asp Ala Glu Lys Val Leu Cys 
                405                 410                 415     


Ser Lys Lys Thr Leu Ser Glu Asn Lys Leu Asp Val Leu Trp Leu Cys 
            420                 425                 430         


Glu Asn Thr Trp Arg Ser Phe Leu Ser Phe Ile Cys Ser Lys Ala Val 
        435                 440                 445             


Asp Met Gly Lys Ala Val Tyr His Phe Ala Met Pro Asn Leu Glu Lys 
    450                 455                 460                 


Ile Glu Ser Gly Lys Pro Val Arg Ala Gly Glu Ile Lys Pro Gln Phe 
465                 470                 475                 480 


Arg Lys Gly Ile Thr Ser Phe Asp Tyr Glu Lys Ile Lys Ala Glu Glu 
                485                 490                 495     


Asn Leu Glu Arg Ser Phe Met Thr Ala Ile Ser Phe Ala Leu Asn Asn 
            500                 505                 510         


Phe Ser Ser Ala Val Cys Pro Pro Glu Thr Tyr Glu Lys Glu Gly Lys 
        515                 520                 525             


Glu Asp Ile Leu Phe Met Gly Asp Asp Ala Leu Gln Lys Glu Met Tyr 
    530                 535                 540                 


Pro Asn Ala Ser Trp Arg Ile Leu Gln Tyr Phe Gly Gly Ala Ser Gln 
545                 550                 555                 560 


Trp Lys Asp Ser Arg Phe Glu Glu Val Ser Asp Ser Gln Lys Ala Val 
                565                 570                 575     


Leu Ile Asn Glu Ser Phe Val Pro Glu Ile Arg Arg Ala Met Gln Leu 
            580                 585                 590         


Ile Arg Asn Ser Ala Phe His Tyr Ala Ala Ser Ala Ala Gln Ser Thr 
        595                 600                 605             


Leu Asp Ser Thr Ser Tyr Leu Val Glu Ile Phe Glu Arg Glu Lys Lys 
    610                 615                 620                 


Leu Ile Gly Ser Lys Tyr Arg Lys Lys Tyr Val Ser Asn Asn Val Pro 
625                 630                 635                 640 


Val Phe Tyr Lys Val Glu Asp Ile Asp His Leu Met Lys Ser Leu Tyr 
                645                 650                 655     


Gly Ser Gln Lys Val Leu Glu Ser Gln Ile Pro Ser Phe Arg Asn Val 
            660                 665                 670         


Ile Ser Arg Lys Ser Leu Pro Glu Leu Ile Asn Gln Tyr Phe Ile Ile 
        675                 680                 685             


Asn Gly Thr Pro Tyr Arg Lys Met Lys Asn Asp Val Ala Thr Ser Glu 
    690                 695                 700                 


Lys Phe His Ala Ala Leu Tyr Phe Val Leu Lys Glu Ile Tyr Tyr Asn 
705                 710                 715                 720 


Gly Phe Leu Gln Glu Asp Asn Leu Met Glu Arg Phe Met Asp Ser Phe 
                725                 730                 735     


His Asp Glu Leu Lys Glu Val Arg Asp Asn Thr Ser Lys Ala Ser Ala 
            740                 745                 750         


Lys Lys Val Lys Ala Met Glu Asn Phe Glu Glu Arg Ile Lys Glu Leu 
        755                 760                 765             


Arg Lys Gly Asn Lys Ser Leu Ser Phe Gly Glu Val Cys Gln Ala Ile 
    770                 775                 780                 


Met Thr Asp Tyr Asn Leu Gln Asn Asn Gln Lys Lys Val Arg Leu Asn 
785                 790                 795                 800 


Gly Lys Asp Asn Leu Pro Asp Glu Lys Tyr Lys His Phe Lys Met Leu 
                805                 810                 815     


Leu Leu Val Cys Leu Arg Arg Thr Phe Val Asp Tyr Leu Gln Lys Asp 
            820                 825                 830         


Val Glu Gly Glu Arg Phe Gly Cys Lys Phe Leu Lys Glu Pro Arg Leu 
        835                 840                 845             


Lys Glu Lys Ile Tyr Asp Asn Leu Thr Glu Glu Gln Phe Cys Asn Gly 
    850                 855                 860                 


Trp Gln Thr Asp Arg Tyr Asn Asn Leu Met Lys Gly Asp Ser Ser Tyr 
865                 870                 875                 880 


Asp Ser Trp Leu Ile Ser Trp Phe Ile Met Ala His Phe Met Thr Pro 
                885                 890                 895     


Lys His Leu Asn His Leu Arg Gly Glu Ile Lys Ser Tyr Leu Ser Tyr 
            900                 905                 910         


Val Gln Asn Ile Glu Arg Arg Arg Trp Asn Ala Thr Gly Ile Gln Ile 
        915                 920                 925             


Glu Asp Glu Lys Glu Lys Arg Lys Lys Tyr Glu Gln Val Leu Glu Val 
    930                 935                 940                 


Leu Glu Leu Ala Ala Glu Tyr Cys Gly Gln Val Ser Lys Glu Arg Thr 
945                 950                 955                 960 


Asp Tyr Tyr Glu Ser Glu Glu Glu Tyr Ala Arg His Ile Ser Arg Tyr 
                965                 970                 975     


Ile Ala Phe Asp Asp Ser Lys Ser Glu Arg Pro Leu Glu Glu Gln Leu 
            980                 985                 990         


Tyr Gly Phe Cys Asn Gln Lys Val  Ala Gly Gly Thr Ala  Asn Arg Ile 
        995                 1000                 1005             


Gly Ile  Phe Tyr Asp Gly Glu  Asn Pro Val Leu Asn  Arg Asn Val 
    1010                 1015                 1020             


Val Ile  Ala Lys Leu Tyr Gly  Thr Glu Gly Leu Leu  Ser Glu Cys 
    1025                 1030                 1035             


Leu Gln  Asp Asp Arg Val Thr  Lys Ala Asp Ile Glu  Lys Tyr Tyr 
    1040                 1045                 1050             


Lys Leu  Ala Asp Ser Asp Ser  Leu Lys Ala Val Phe  Lys Tyr Gly 
    1055                 1060                 1065             


Gly Cys  Lys Asn Gln Lys Gln  Glu Glu Glu Arg Arg  Glu Tyr Gln 
    1070                 1075                 1080             


Gln His  Lys Asn Arg Ile Glu  Leu Val Asp Ile Leu  Lys Tyr Ser 
    1085                 1090                 1095             


Asp Leu  Leu Asn Asp Phe Met  Ser Gln Leu Ile Ser  Trp Cys Tyr 
    1100                 1105                 1110             


Leu Arg  Glu Arg Asp Arg Met  Tyr Phe Gln Met Gly  Leu His Tyr 
    1115                 1120                 1125             


Ile Arg  Leu Tyr Tyr Gly Lys  Asn Ile Val Glu Lys  Asp Ser Arg 
    1130                 1135                 1140             


Phe Arg  Ile Leu Gln Ser Lys  Glu Val Arg Ala Gly  Gly Glu Arg 
    1145                 1150                 1155             


Gly Ile  His Leu Thr Asp Gly  Ala Ile Leu Tyr Gln  Leu Ala Ala 
    1160                 1165                 1170             


Ile Tyr  Thr Tyr Glu Tyr Pro  Val Tyr Ala Leu Asp  Glu Glu Gly 
    1175                 1180                 1185             


Asn Ala  Thr Val Ser Lys Lys  Ala Lys Ser Gly Ser  Thr Thr Ala 
    1190                 1195                 1200             


Asn Ser  Ile Thr Ala Phe Trp  Lys Glu Tyr Cys Glu  Gly Asp Ala 
    1205                 1210                 1215             


Ser Ala  Tyr Glu Met Gly Leu  Arg Leu Phe Glu Asn  Pro Ile Glu 
    1220                 1225                 1230             


Glu Gly  Glu Leu Ile Ser Phe  Arg Asn Tyr Ile Asp  His Phe Lys 
    1235                 1240                 1245             


Tyr Tyr  Ser Gln Arg Asp Arg  Ser Ile Leu Asp Leu  Tyr Ser Gln 
    1250                 1255                 1260             


Val Phe  Ala Thr Tyr Phe Arg  Asn Asp Lys Lys Leu  Lys Lys Ser 
    1265                 1270                 1275             


Val Thr  Phe Ile Phe Lys Asn  Ile Leu Ala Arg His  Phe Val Ile 
    1280                 1285                 1290             


Ala Lys  Thr Val Leu Asp Val  His Asp Glu Pro Lys  Lys Asp Lys 
    1295                 1300                 1305             


Arg Lys  Asp Lys Lys Asn Pro  Lys Ile Arg Thr Tyr  Lys Gln Ala 
    1310                 1315                 1320             


Glu Ile  Arg Ile Ala Glu Lys  Asp Gly Leu Glu Ser  Asp Val Thr 
    1325                 1330                 1335             


Ile His  Lys Tyr Thr Lys Glu  Asp Leu Asp Glu Ala  Tyr Lys Lys 
    1340                 1345                 1350             


Lys Ala  Glu Gly Asp Arg Asn  Ile Arg Val Pro Lys  Glu Gly Gly 
    1355                 1360                 1365             


Lys Tyr  Ser Ile Leu Leu Tyr  Asp Glu Ser Phe Ile  Glu Arg Leu 
    1370                 1375                 1380             


Tyr Arg  Ile Leu Asn Tyr His  Lys 
    1385                 1390     


<210>  1061
<211>  971
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1061

Met Lys Arg Glu Lys Asn Ile Thr Ile Met Lys Ile Ser Lys Val Asn 
1               5                   10                  15      


His Arg Arg Thr Ala Val Ala Leu Asn Gly Asp Lys Ser Glu Leu Gly 
            20                  25                  30          


Gly Ile Leu Tyr Glu Ala Pro Val Gln Lys Asp Lys Asn Gly Asn Tyr 
        35                  40                  45              


Asn Asp Val Ile Ala Glu Thr Gly Lys Val Val Asn Glu Ala Leu Asp 
    50                  55                  60                  


Lys Lys Ser Arg Leu Tyr Thr Pro Phe Asn Asn Gln Lys Val Ile Ile 
65                  70                  75                  80  


Asp Lys Asn Leu Gln Arg Tyr Ala Asn Asn Leu Lys Arg Cys Tyr Ile 
                85                  90                  95      


Asn Phe Val Lys Gln Tyr Val Asn Asn Lys Ser Phe Asn Tyr Lys Ala 
            100                 105                 110         


Met Gln Phe Ile Pro Asp Ile Gln Asn Pro Lys Thr Asn Asp Ala Val 
        115                 120                 125             


Asn Tyr Arg Thr Asp Arg Asp Asn Val Tyr Asn Lys Asn Lys Tyr Tyr 
    130                 135                 140                 


Asp Lys Gln Thr Lys Ser Lys Ser Lys Lys Phe Ile Tyr Glu Lys Ile 
145                 150                 155                 160 


Val Ile Pro Gln Asn Glu Gln Asn Ile Val Ile Ser Ala Leu Val Asn 
                165                 170                 175     


Cys Ser Leu Arg Lys Ser Leu Arg Lys Asp Val Ser Tyr Lys Thr Lys 
            180                 185                 190         


Ser Gly Glu Ile Lys Thr Tyr Asn Leu Pro Glu Leu Val Lys Lys Ser 
        195                 200                 205             


Met Arg Phe Tyr Cys Leu Glu Gly Gln Arg Glu Pro Asp Glu Lys Glu 
    210                 215                 220                 


Lys Tyr Glu Met Tyr Ile Leu Phe Ser Tyr Met Lys Glu Asp Lys Arg 
225                 230                 235                 240 


Thr Lys Asn Thr Asp Leu Leu Val Lys Ser Ile Ser Asn Gln Asn Thr 
                245                 250                 255     


Lys Val Lys Val Glu Asp Ile Asp Gly Asn Lys Leu Leu Lys Leu Ser 
            260                 265                 270         


Ile Ala Asp Thr Lys Lys Lys Pro Leu Trp Glu Tyr Leu Ile Lys Tyr 
        275                 280                 285             


Ala Asp Ser Ser Arg Gln Arg Glu Leu Met Tyr Asp Ile Arg Lys Lys 
    290                 295                 300                 


Ile Ile Leu Tyr Val Ala Gly Ile Glu Glu Tyr Glu Asn Ile Lys Glu 
305                 310                 315                 320 


Asp Ser Gly Leu Ser Lys Val Ser Trp Ser Lys Tyr Asn Ile Ser Asp 
                325                 330                 335     


Asn Lys Met Phe Phe Asp Ile Asn Ser Cys Thr Asp Lys Arg Lys Gln 
            340                 345                 350         


Asn Leu Glu Ile Lys Ile Arg Glu Ala Asn Ile Glu His Tyr Arg Asn 
        355                 360                 365             


Ala Ser Ser Lys Leu Cys Asp Asp Glu Ser Ile Phe Trp Phe Gln His 
    370                 375                 380                 


Phe Glu Gly Val Ile Glu Thr Leu Phe Ser Lys Lys Ser Lys Ile Ser 
385                 390                 395                 400 


Glu Glu Arg Leu Gly Cys Ala Tyr Ile Cys Asp Tyr Leu Trp Lys Asp 
                405                 410                 415     


Phe Leu Ser Tyr Leu Ala Ala Lys Tyr Ile Asp Leu Gly Lys Gly Val 
            420                 425                 430         


Tyr His Phe Thr Met Lys Asp Lys Leu Asp Met Leu Asn Lys Asn Glu 
        435                 440                 445             


Ala Val Thr Asp Leu Arg Phe Gly Ile Val Ser Glu Lys Tyr Glu Lys 
    450                 455                 460                 


Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Glu Leu 
465                 470                 475                 480 


Asp Arg Asn Ile Ala Ala Tyr Val Thr Phe Ala Ala Asp Ile Phe Ala 
                485                 490                 495     


Lys Ser Val Ile Lys Ser Asp Tyr Arg Thr Lys Lys Asp Asn Asn Ser 
            500                 505                 510         


Asp Val Leu Gln Tyr Ser Asp Lys Glu Phe Arg Asn Ser Glu Val Ile 
        515                 520                 525             


Arg Asp Asn Ala Glu Lys Asn Ile Leu Gln Tyr Trp Gly Gly Tyr Ser 
    530                 535                 540                 


Arg Trp Cys Thr Glu Asn Ser Lys Leu Pro Glu Asn Asn Lys Val Ser 
545                 550                 555                 560 


Asp Phe Gly Lys Leu Asp Val Ser Asp Leu Cys Ile Asp Ile Lys Lys 
                565                 570                 575     


His Leu Ala Gly Ile Arg Asn Ser Ser Val His Tyr Thr Thr Lys Ile 
            580                 585                 590         


Lys Asn Glu Ser Ala Ala Asp Gly Ser Asn Val Lys Ile Leu Phe Glu 
        595                 600                 605             


Lys Asp Leu Ala Asp Ile Asn Ile Ile Tyr Ala Asp Lys Tyr Tyr Ser 
    610                 615                 620                 


Asn Asn Val Trp Met Phe Tyr Ser Leu Glu Asp Ile Asn Lys Leu Ile 
625                 630                 635                 640 


Ala Phe Leu Tyr Lys Glu Lys Arg Val Ile Arg Gln Val Gln Ile Pro 
                645                 650                 655     


Ser Phe Ser Arg Ile Leu Lys Arg Lys Ala Met Gln Asp Val Ile Asn 
            660                 665                 670         


Glu Ile Phe Lys Asp Asp Phe Asp Glu Asn Ile Val Asn Pro Glu Leu 
        675                 680                 685             


Lys Glu Lys Tyr Arg Asn Ser Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
    690                 695                 700                 


Tyr Asn Ala Phe Ile Ile Gln Pro Glu Leu Lys Glu Lys Phe Lys Asp 
705                 710                 715                 720 


Lys Ile Lys Thr Met Lys Ser Glu Leu Tyr Asn Lys Leu Lys Thr Ile 
                725                 730                 735     


Asp Lys Lys Glu Tyr Lys Ala Leu Tyr Cys Met Leu Ser Asn Glu Glu 
            740                 745                 750         


Ser Ala Leu Lys Asn Phe Ala Asp Arg Ile Tyr Ser Val Asp Gly Asp 
        755                 760                 765             


Asn Val Ser Phe Ala Asp Ile Cys Lys Ile Leu Met Thr Asp Tyr Asn 
    770                 775                 780                 


Met Gln Asn Gln Glu Lys Lys Asn Ile Glu Ser Met Glu Gln Lys Lys 
785                 790                 795                 800 


Lys Asn Lys Gly Lys Asp Glu Asn Tyr Lys His Phe Pro Leu Leu Leu 
                805                 810                 815     


His Lys Val Leu Lys Glu Leu Phe Ile Glu Tyr Leu Lys Gln Thr His 
            820                 825                 830         


Glu Leu Glu Phe Leu Arg Asn Asn Ile Cys Ile Lys Ser Asp Val Thr 
        835                 840                 845             


Met Glu Ser Phe Glu Ser Gln Ile Lys Gly Val Glu Ile Tyr Lys Asp 
    850                 855                 860                 


Leu Lys Glu Lys Ile Asp Lys Asn Asn Ser Leu Leu Asp Trp Tyr Val 
865                 870                 875                 880 


Ile Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asn 
                885                 890                 895     


Ile Lys Asn Tyr Ile Gln Phe Ala Thr Asn Ile Asp Lys Arg Ala Glu 
            900                 905                 910         


Ser Val Lys Asn Leu Thr Glu Ser Gly Met Val Lys Arg Ile Gln Tyr 
        915                 920                 925             


Tyr Asp Asp Ile Val Arg Thr Leu Glu Phe Ser Ala Gln Tyr Ile Gly 
    930                 935                 940                 


Lys Ile Ser Asn Asn Ile Asn Asp Tyr Phe Asn Ser Glu Asp Glu Tyr 
945                 950                 955                 960 


Val Ser Phe Tyr Asn Lys Asn Thr Ile Lys Ile 
                965                 970     


<210>  1062
<211>  1101
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1062

Met Arg Ile Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Ile Tyr Ser Glu 
            20                  25                  30          


Gln Ala Val Ser Asn Glu Thr Asn Asn Ile Leu Pro Val Lys Lys Met 
        35                  40                  45              


Asp Ser Phe Asn Leu Ser Ile Leu Asn Lys Thr Ile Ile Lys Phe Glu 
    50                  55                  60                  


Thr Val Lys Lys Gln Lys Leu Asn Leu Asp Gln Tyr Lys Ile Val Glu 
65                  70                  75                  80  


Lys Ile Phe Lys Tyr Pro Lys Gln Glu Leu Pro Lys Gln Ile Asn Ala 
                85                  90                  95      


Glu Glu Ile Leu Gln Phe Leu Asn His Lys Phe Gln Glu Pro Val Lys 
            100                 105                 110         


Tyr Trp Lys Asn Gly Lys Glu Glu Ser Phe Asn Leu Thr Leu Leu Ile 
        115                 120                 125             


Val Glu Ala Val Lys Thr Gln Glu Lys Arg Lys Leu Gln Pro Tyr Tyr 
    130                 135                 140                 


Asp Trp Lys Thr Trp Tyr Ile Gln Thr Lys Ser Asp Leu Leu Lys Lys 
145                 150                 155                 160 


Ser Ile Glu Asn Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg 
                165                 170                 175     


Lys Lys Ala Leu Leu Ala Trp Glu Thr Glu Phe Thr Thr Ser Gly Ser 
            180                 185                 190         


Ile Asp Leu Thr His Phe His Lys Val Tyr Met Thr Asp Val Leu Cys 
        195                 200                 205             


Thr Ala Leu Gln Lys Val Glu Pro Ser Ala Asp Glu Arg Gly Lys Met 
    210                 215                 220                 


Asn Ser Asn Ala Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Asn His 
225                 230                 235                 240 


Gln Pro Ala Ile Phe Gly Thr Arg Glu Ala Pro Asn Glu Val Asn Arg 
                245                 250                 255     


Ala Asp Asn Gln Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu 
            260                 265                 270         


Glu His Tyr Phe Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Ala Asp 
        275                 280                 285             


Asp Ile Ser His Tyr Leu Lys Ala Gln Thr Leu Lys Thr Thr Ile Glu 
    290                 295                 300                 


Lys Gln Leu Val Asn Ala Ile Arg Ala Asn Ile Ile Gln Gln Gly Lys 
305                 310                 315                 320 


Thr Asn His His Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile 
                325                 330                 335     


Arg Ile Lys Thr Asn Glu Ala Phe Val Leu Asn Leu Ile Gly Thr Cys 
            340                 345                 350         


Ala Phe Ala Ala Asn Asn Ile Arg Asn Met Val Asp Lys Glu Gln Ile 
        355                 360                 365             


Ser Asp Ile Leu Gly Lys Arg Glu Phe Ile Asp Ser Leu Thr Lys Ser 
    370                 375                 380                 


Arg Ile Ser Ser Gln Leu Tyr Ser Phe Phe Phe Gly Glu Asn Leu Ser 
385                 390                 395                 400 


Thr Asn Lys Ala Glu Lys Glu Thr Gln Leu Trp Gly Ile Arg Gly Ala 
                405                 410                 415     


Val Gln Gln Ile Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu 
            420                 425                 430         


Thr Thr Ile Phe Asn Ile Cys Lys Phe Glu Asn Pro Thr Asp Ala Asp 
        435                 440                 445             


Pro Lys Gln Gln Thr Asn Tyr Val Asp Ser Ile Tyr Lys Thr Leu Phe 
    450                 455                 460                 


Ile Lys Glu Leu Glu Lys Ile Pro Glu Ala Phe Ala Gln Gln Leu Lys 
465                 470                 475                 480 


Thr Gly Gly Ala Leu Ser Tyr Tyr Thr Val Glu Asn Leu Lys Thr Leu 
                485                 490                 495     


Leu Thr Thr Phe Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala 
            500                 505                 510         


Pro Gly Phe Lys Lys Val Leu Asn Gly Gly Ile Asn Tyr Gln Asn Ala 
        515                 520                 525             


Lys Gln Asp Glu Ser Phe Tyr Glu Leu Met Leu Glu Arg Tyr Leu Arg 
    530                 535                 540                 


Lys Glu Asn Phe Ala Glu Glu Ala Tyr Asn Ala Arg Tyr Phe Leu Leu 
545                 550                 555                 560 


Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Lys Phe Thr Ala Asp Arg 
                565                 570                 575     


Lys Ala Phe Ala Asp Ser Val Gly Phe Val Gln Leu Gln Asn Arg Lys 
            580                 585                 590         


Gln Ala Glu Asn Ser Lys Arg Pro Lys Ala Phe Ala Phe Glu Ala Val 
        595                 600                 605             


Arg Pro Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala Tyr Val 
    610                 615                 620                 


Gln Ser Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys Ala Thr 
625                 630                 635                 640 


Asp Glu Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val Phe Ile 
                645                 650                 655     


Lys Gly Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe Val Gln 
            660                 665                 670         


Val Pro Gln Pro Gln Leu Thr Thr Thr Asp Ser Asn Gln Gln Lys Ala 
        675                 680                 685             


Asp Lys Leu Asn Gln Leu Glu Ala Ser Ile Thr Ala Asp Cys Lys Leu 
    690                 695                 700                 


Thr Ala Gln Tyr Ala Lys Thr Asp Asp Ala Thr His Ile Ala Phe Tyr 
705                 710                 715                 720 


Val Phe Cys Lys Leu Leu Asp Ala Gly His Leu Ser Asn Leu Arg Asn 
                725                 730                 735     


Glu Leu Ile Lys Phe Arg Gly Ser Val Lys Asp Phe Asp Phe His His 
            740                 745                 750         


Leu Leu Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val Val Pro 
        755                 760                 765             


Thr Asp Tyr Arg Asp Leu Tyr Ser Ser Gly Ala Asp Cys Leu Ala Arg 
    770                 775                 780                 


Leu Arg Pro Phe Ile Glu Gln Gly Ala Asp Ile Lys Asn Trp Ser Asp 
785                 790                 795                 800 


Leu Tyr Val Gln Thr Asp Lys Gln Thr Pro Val Ile His Ala Gly Ile 
                805                 810                 815     


Glu Leu Ser Val Lys Tyr Gly Thr Thr Ala Leu Leu Glu Gln Leu Ile 
            820                 825                 830         


Thr Cys Asn Pro Lys Phe Arg Val Met Glu Asp Asn Phe Thr Lys Trp 
        835                 840                 845             


Ser Ala Gln Lys Lys Glu Ile Glu Glu Lys Val Asn Lys His Thr Asn 
    850                 855                 860                 


Leu His Gln Gln Trp Val Glu Ala Lys Glu Lys Asp Asp Arg Glu Arg 
865                 870                 875                 880 


Val Lys Ser Lys Lys Asn Phe Val Arg Glu Tyr Val Lys Lys Asn Tyr 
                885                 890                 895     


Val Asp Tyr Ile Asn Asn Cys Ile Glu Ile Asn Asn Tyr Asn Trp Leu 
            900                 905                 910         


Asp Asn Lys Leu His Phe Val His Leu Asn His Leu His His Leu Thr 
        915                 920                 925             


Ile Asp Ile Leu Gly Arg Met Ala Gly Phe Val Ala Leu Trp Glu Arg 
    930                 935                 940                 


Asp Phe Gln Tyr Ile Thr Lys Tyr Thr Ala Ala Lys Glu Gly Thr Asp 
945                 950                 955                 960 


Ala Leu Ser Phe Asp Gly Gly Leu Pro Arg Leu Lys Asp Lys Gln Glu 
                965                 970                 975     


Tyr Tyr Asn Lys Leu Phe Leu Ser Asp Lys Tyr Thr Lys Val Arg Asn 
            980                 985                 990         


His Ile Ala His Phe Asn Tyr Leu  Thr Lys Asp Ala Ala  Asp Phe Ala 
        995                 1000                 1005             


Leu Leu  Asp Leu Ile Asn Glu  Leu Arg Glu Leu Leu  His Tyr Gly 
    1010                 1015                 1020             


Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ala Phe Ile  Asp Leu Phe 
    1025                 1030                 1035             


Glu Lys  His Gly Met Ile Leu  Lys Leu Lys Leu Asn  Thr Asp His 
    1040                 1045                 1050             


Gln Leu  Val Val Glu Ser Ile  Glu Pro Lys Lys Ile  Tyr His Leu 
    1055                 1060                 1065             


Gly Ser  Thr Ala Lys Asp Lys  Pro Glu Tyr Gln Tyr  Thr Thr Asn 
    1070                 1075                 1080             


Gln Val  Met Thr Val Tyr Cys  Asn Met Cys Arg Ser  Leu Leu Glu 
    1085                 1090                 1095             


Met Lys  Lys 
    1100     


<210>  1063
<211>  1185
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1063

Met Arg Ile Ile Lys Pro Tyr Gly Arg Ser Val Val Glu Lys Ala Gly 
1               5                   10                  15      


Pro Gly Arg Leu Ala Arg Ala Val Ser Leu His Pro Asp Pro Ala Arg 
            20                  25                  30          


Gly Val Glu Leu Asp Asn Arg Lys Ser Val Val Glu Phe Ala Ala Ser 
        35                  40                  45              


His Asp Arg Leu Val Ile Ala Gln Trp Ile Ser Thr Ile Asp Lys Ile 
    50                  55                  60                  


Ala Arg Lys Pro Val Gly Glu Ala Ala Ala Thr Pro Gln Gln Ala Glu 
65                  70                  75                  80  


Phe Arg Arg Arg Leu Gly Asp Ala Ala Trp Thr Leu Ile Glu Arg Arg 
                85                  90                  95      


Ala Leu Leu Thr Gly Leu Asn Asp Pro Ala Val Lys Ala Arg Leu Arg 
            100                 105                 110         


Arg Leu Trp Glu Phe Lys Ile Ala Pro Tyr Lys Thr Ala Arg Ala Val 
        115                 120                 125             


Ala Lys Thr Gly Thr Arg Pro Pro Arg Leu Lys Gly Trp Trp Phe Arg 
    130                 135                 140                 


Arg Phe Ala Gly Asp Val Glu Glu Val Asp Lys Val Asp Ala Asp Ala 
145                 150                 155                 160 


Val Ala Leu Ala Ile His Glu His Leu Tyr Ser Ala Gln Tyr Gln Met 
                165                 170                 175     


Arg Val Asp Asp Arg Thr Arg Leu Ser Gly Leu Ile Ala Ala Arg Ala 
            180                 185                 190         


Glu Ser Ile Ala Gly Asn Val Leu Gln Pro His Ala Ala Ala Arg Asp 
        195                 200                 205             


Lys Asp Gly Gly Trp Ser Glu Asp Asp Gln Arg Arg Tyr Ala Ala Ala 
    210                 215                 220                 


Gly Asp Val Ala Arg Glu Ile Arg Ser Ala Ala Glu Ala Arg Glu Arg 
225                 230                 235                 240 


Gly Asp Gly Lys Ile Gly Pro Arg Arg Val Thr Ser Glu Val Ala Gly 
                245                 250                 255     


Ala Ala Leu Phe Glu His Tyr Ala Arg Leu Phe Arg Gly Ala Asp Gly 
            260                 265                 270         


Lys Ala Met Gly Val Ala Gln Ala Arg Asp Gln Glu Ser Gly Leu Phe 
        275                 280                 285             


Asn Leu His Met Ala Val Lys Asp Cys Tyr Ala Arg Ile Leu Lys Gly 
    290                 295                 300                 


His Gly Lys Asp Leu Ala Lys His Gly Glu Gly Arg Arg Arg Val Ser 
305                 310                 315                 320 


Thr Leu Leu Pro Pro Thr Ser Val Asp Leu Phe Arg Leu Leu Asp Ala 
                325                 330                 335     


Met Leu Asp Asn Arg Asp Leu Asn Ala Leu Val Arg Leu Gly Lys Val 
            340                 345                 350         


Ile His Tyr Glu Ser Ala Gly Ala Gly Val Asp Arg Pro Ala Asp Val 
        355                 360                 365             


Val Asp His Trp Pro Ala Asp Val Ala Asp Ser Asp Tyr Trp Thr Ser 
    370                 375                 380                 


Asp Gly Gln Ala Arg Ile Lys Arg Asn Glu Ala Leu Val Arg Val Trp 
385                 390                 395                 400 


Arg His Val Leu Ala Leu Ala Ser Arg Thr Leu Thr Asp Trp Ala Asp 
                405                 410                 415     


Pro Lys Gly Met Ile Gly Gly Asp Ile Leu Leu Lys Asp Ser Val Glu 
            420                 425                 430         


Thr Ala Ile Ala Asn Phe Asp Ala Glu Ser Tyr Lys Arg Lys Ile Glu 
        435                 440                 445             


Val Leu Phe Gly Gly Arg Ala Ala Leu Phe Asp Gly Asp Gly Asp Glu 
    450                 455                 460                 


Ala Phe Glu Lys Asp Val Leu Arg Phe Ala Leu His Gly Val Ala Ala 
465                 470                 475                 480 


Leu Arg Asn Ala Ala Phe His Phe Lys Gly Val Gly Gly Phe Ala Glu 
                485                 490                 495     


Ala Leu Lys Thr Leu Gly Pro Arg Gln Asp Pro Arg Val Thr Ala Ala 
            500                 505                 510         


Val Asp Gly Leu Trp Arg Thr Asp Glu Glu Gly Arg Gly Arg Arg Leu 
        515                 520                 525             


Leu Ala Thr Met Arg Gly Ala His Phe Glu Ser Phe Phe Asp Gln Arg 
    530                 535                 540                 


Gln Asn Arg Arg Leu Ala Gln Ala Leu Ser Arg Ala Ser Glu Glu Ser 
545                 550                 555                 560 


Leu Pro Leu Pro Arg Phe Ala Val Met Leu Arg Arg Ala Glu Asn Ala 
                565                 570                 575     


Trp Asp Arg Leu Gly Leu Pro Lys Thr Ala Asn Arg Ala Asp Leu Glu 
            580                 585                 590         


Ala Pro Ala Arg His Cys Gln Tyr Val Ala Leu Lys Leu Leu Tyr Glu 
        595                 600                 605             


Arg Pro Phe Arg Ala Trp Leu Ala Glu Arg Asp Ala Ala Thr Leu Asn 
    610                 615                 620                 


Arg Phe Ile Val Cys Ala Val Glu Arg Ala Thr Lys Ala Ala Arg Met 
625                 630                 635                 640 


Leu Asn Pro Gly Ala Ser Arg Glu Leu Ala Glu Ala Ile Thr Ala Lys 
                645                 650                 655     


Ala Ala Asp Leu Gly Arg Leu Gly Asn Asp Asp Ser Val Glu Asp Phe 
            660                 665                 670         


Phe Phe Arg Leu Ser Ala Glu Thr Ala Gly Glu Ala Arg Val Gln Arg 
        675                 680                 685             


Gly Tyr Glu Ser Asp Ala Glu Asn Ala Arg Ala Gln Ala Ser His Ile 
    690                 695                 700                 


Glu Asn Leu Lys Ala Asp Leu Val Ala Leu Ala Phe Arg Asp Tyr Leu 
705                 710                 715                 720 


Gln Lys Ala Asp Phe Glu Phe Ala Leu Lys Leu Arg Gly Asp Glu Pro 
                725                 730                 735     


Leu Pro Thr Lys Pro Met Cys Ala Leu Asp Glu Ala Asp Phe Val Glu 
            740                 745                 750         


Gly Glu Ala Ser Ser Ala Glu Pro Pro Cys Glu Leu Tyr Phe Leu Leu 
        755                 760                 765             


His Leu Val Pro Val Asp Glu Val Gly Lys Leu Leu His Gln Leu Arg 
    770                 775                 780                 


Lys Trp Gln Ile Leu Ala Pro Pro Ala Pro Ala Ala Thr Gly Gly Pro 
785                 790                 795                 800 


Thr Thr Ala Ala Thr Val Ala Glu Ile Arg Leu Ala Leu Glu Leu Tyr 
                805                 810                 815     


Leu Asp Met His Asp Ala Lys Phe Glu Gly Gly Ala Ala Leu Val Gly 
            820                 825                 830         


Val Glu Pro Phe Lys Arg Leu Phe Glu Gly Asp Gly Leu Phe Gly Arg 
        835                 840                 845             


Ile Phe Glu Arg Pro Ala Gly Asp Arg Pro Gly Ala Glu Asp Asp Arg 
    850                 855                 860                 


Arg Leu Pro Arg Arg Gly Leu Arg Glu Ile Met Arg Phe Gly His Leu 
865                 870                 875                 880 


Arg Pro Leu Leu Pro Ile Phe Asp Lys Gln Pro Ile Arg Ala Asp Glu 
                885                 890                 895     


Val Ala Ala Tyr Leu Asp Ala Glu Gln Val Pro Asp Gly Gly Lys Ser 
            900                 905                 910         


Glu Ile Ala Arg Arg Gln Glu Arg Arg Glu Ala Leu His Glu Lys Trp 
        915                 920                 925             


Ala Arg Arg Arg Arg Glu Phe Ser Asp Asp Asp Arg Arg Ala Tyr Glu 
    930                 935                 940                 


Glu Ala Leu Arg Phe Val Glu Glu His Arg His Arg Ala Ala Arg Val 
945                 950                 955                 960 


Thr Leu Thr Asp His Val Arg Leu His Arg Leu Leu Met Ala Val Leu 
                965                 970                 975     


Gly Arg Leu Val Asp Tyr Ser Gly Leu Trp Glu Arg Asp Leu Tyr Phe 
            980                 985                 990         


Val Ala Leu Ala Leu Ile His Gln  Ala Gly Arg Arg Leu  Asp Glu Ile 
        995                 1000                 1005             


Phe Ala  Ala Asp Gly Leu Ala  Met Leu Arg Glu Gly  Arg Val Val 
    1010                 1015                 1020             


Glu Ala  Leu Arg Lys Leu Ala  Asp Ile Asp Ala Ala  Arg Ala Ile 
    1025                 1030                 1035             


Ala Ala  Glu Val Lys Arg Arg  Phe Asp Gly Ala Pro  Asp Ala Ala 
    1040                 1045                 1050             


Ser Arg  Val Val Lys Ile Arg  Asn Ala Phe Ala His  Phe Asn Met 
    1055                 1060                 1065             


Leu Arg  Pro Lys Arg Gly Gly  Ala Thr Ala Ala Leu  Asp Leu Thr 
    1070                 1075                 1080             


Ala Ala  Val Asn Asp Gly Arg  Glu Leu Met Ala Tyr  Asp Arg Lys 
    1085                 1090                 1095             


Leu Lys  Asn Ala Val Ser Arg  Ser Ile Ala Glu Leu  Leu Glu Arg 
    1100                 1105                 1110             


Glu Gly  Leu Ala Val Ala Trp  Ser Val Asn Glu His  Arg Leu Glu 
    1115                 1120                 1125             


Ala Thr  Arg Val Ser Thr Arg  Gln Ala Ser His Leu  Ala Asn Ser 
    1130                 1135                 1140             


Gly Leu  Arg Glu Asp Leu His  Gly Ala Gly Tyr Val  Ala Thr Val 
    1145                 1150                 1155             


Ala Glu  Leu Phe Gly Arg Thr  Ala Ala Lys Pro Ala  Ala Pro Leu 
    1160                 1165                 1170             


Ala Arg  Arg Glu Asn Arg Thr  Ala Arg Gly Gly Arg  
    1175                 1180                 1185 


<210>  1064
<211>  1176
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1064

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly 
    1175     


<210>  1065
<211>  1101
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1065

Met Arg Ile Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Ile Tyr Ser Glu 
            20                  25                  30          


Gln Ala Val Ser Asn Glu Thr Asn Asn Ile Leu Pro Val Lys Lys Met 
        35                  40                  45              


Asp Ser Phe Asn Leu Ser Ile Leu Asn Lys Thr Ile Ile Lys Phe Glu 
    50                  55                  60                  


Thr Val Lys Lys Gln Lys Leu Asn Leu Asp Gln Tyr Lys Ile Val Glu 
65                  70                  75                  80  


Lys Ile Phe Lys Tyr Pro Lys Gln Glu Leu Pro Lys Gln Ile Asn Ala 
                85                  90                  95      


Glu Glu Ile Leu Gln Phe Leu Asn His Lys Phe Gln Glu Pro Val Lys 
            100                 105                 110         


Tyr Trp Lys Asn Gly Lys Glu Glu Ser Phe Asn Leu Thr Leu Leu Ile 
        115                 120                 125             


Val Glu Ala Val Lys Thr Gln Glu Lys Arg Lys Leu Gln Pro Tyr Tyr 
    130                 135                 140                 


Asp Trp Lys Thr Trp Tyr Ile Gln Thr Lys Ser Asp Leu Leu Lys Lys 
145                 150                 155                 160 


Ser Ile Glu Asn Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg 
                165                 170                 175     


Lys Lys Ala Leu Leu Ala Trp Glu Thr Glu Phe Thr Thr Ser Gly Ser 
            180                 185                 190         


Ile Asp Leu Thr His Phe His Lys Val Tyr Met Thr Asp Val Leu Cys 
        195                 200                 205             


Thr Ala Leu Gln Lys Val Glu Pro Ser Ala Asp Glu Arg Gly Lys Met 
    210                 215                 220                 


Asn Ser Asn Ala Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Asn His 
225                 230                 235                 240 


Gln Pro Ala Ile Phe Gly Thr Arg Glu Ala Pro Asn Glu Val Asn Arg 
                245                 250                 255     


Ala Asp Asn Gln Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu 
            260                 265                 270         


Glu His Tyr Phe Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Ala Asp 
        275                 280                 285             


Asp Ile Ser His Tyr Leu Lys Ala Gln Thr Leu Lys Thr Thr Ile Glu 
    290                 295                 300                 


Lys Gln Leu Val Asn Ala Ile Arg Ala Asn Ile Ile Gln Gln Gly Lys 
305                 310                 315                 320 


Thr Asn His His Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile 
                325                 330                 335     


Arg Ile Lys Thr Asn Glu Ala Phe Val Leu Asn Leu Ile Gly Thr Cys 
            340                 345                 350         


Ala Phe Ala Ala Asn Asn Ile Arg Asn Met Val Asp Lys Glu Gln Ile 
        355                 360                 365             


Ser Asp Ile Leu Gly Lys Arg Glu Phe Ile Asp Ser Leu Thr Lys Ser 
    370                 375                 380                 


Arg Ile Ser Ser Gln Leu Tyr Ser Phe Phe Phe Gly Glu Asn Leu Ser 
385                 390                 395                 400 


Thr Asn Lys Ala Glu Lys Glu Thr Gln Leu Trp Gly Ile Arg Gly Ala 
                405                 410                 415     


Val Gln Gln Ile Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu 
            420                 425                 430         


Thr Thr Ile Phe Asn Ile Cys Lys Phe Glu Asn Pro Thr Asp Ala Asp 
        435                 440                 445             


Pro Lys Gln Gln Thr Asn Tyr Val Asp Ser Ile Tyr Lys Thr Leu Phe 
    450                 455                 460                 


Ile Lys Glu Leu Glu Lys Ile Pro Glu Ala Phe Ala Gln Gln Leu Lys 
465                 470                 475                 480 


Thr Gly Gly Ala Leu Ser Tyr Tyr Thr Val Glu Asn Leu Lys Thr Leu 
                485                 490                 495     


Leu Thr Thr Phe Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala 
            500                 505                 510         


Pro Gly Phe Lys Lys Val Leu Asn Gly Gly Ile Asn Tyr Gln Asn Ala 
        515                 520                 525             


Lys Gln Asp Glu Ser Phe Tyr Glu Leu Met Leu Glu Arg Tyr Leu Arg 
    530                 535                 540                 


Lys Glu Asn Phe Ala Glu Glu Ala Tyr Asn Ala Arg Tyr Phe Leu Leu 
545                 550                 555                 560 


Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Lys Phe Thr Ala Asp Arg 
                565                 570                 575     


Lys Ala Phe Ala Asp Ser Val Gly Phe Val Gln Leu Gln Asn Arg Lys 
            580                 585                 590         


Gln Ala Glu Asn Ser Lys Arg Pro Lys Ala Phe Ala Phe Glu Ala Val 
        595                 600                 605             


Arg Pro Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala Tyr Val 
    610                 615                 620                 


Gln Ser Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys Ala Thr 
625                 630                 635                 640 


Asp Glu Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val Phe Ile 
                645                 650                 655     


Lys Gly Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe Val Gln 
            660                 665                 670         


Val Pro Gln Pro Gln Leu Thr Thr Thr Asp Ser Asn Gln Gln Lys Ala 
        675                 680                 685             


Asp Lys Leu Asn Gln Leu Glu Ala Ser Ile Thr Ala Asp Cys Lys Leu 
    690                 695                 700                 


Thr Ala Gln Tyr Ala Lys Thr Asp Asp Ala Thr His Ile Ala Phe Tyr 
705                 710                 715                 720 


Val Phe Cys Lys Leu Leu Asp Ala Gly His Leu Ser Asn Leu Arg Asn 
                725                 730                 735     


Glu Leu Ile Lys Phe Arg Gly Ser Val Lys Asp Phe Asp Phe His His 
            740                 745                 750         


Leu Leu Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val Val Pro 
        755                 760                 765             


Thr Asp Tyr Arg Asp Leu Tyr Ser Ser Gly Ala Asp Cys Leu Ala Arg 
    770                 775                 780                 


Leu Arg Pro Phe Ile Glu Gln Gly Ala Asp Ile Lys Asn Trp Ser Asp 
785                 790                 795                 800 


Leu Tyr Val Gln Thr Asp Lys Gln Thr Pro Val Ile His Ala Gly Ile 
                805                 810                 815     


Glu Leu Ser Val Lys Tyr Gly Thr Thr Ala Leu Leu Glu Gln Leu Ile 
            820                 825                 830         


Thr Cys Asn Pro Lys Phe Arg Val Met Glu Asp Asn Phe Thr Lys Trp 
        835                 840                 845             


Ser Ala Gln Lys Lys Glu Ile Glu Glu Lys Val Asn Lys His Thr Asn 
    850                 855                 860                 


Leu His Gln Gln Trp Val Glu Ala Lys Glu Lys Asp Asp Arg Glu Arg 
865                 870                 875                 880 


Val Lys Ser Lys Lys Asn Phe Val Arg Glu Tyr Val Lys Lys Asn Tyr 
                885                 890                 895     


Val Asp Tyr Ile Asn Asn Cys Ile Glu Ile Asn Asn Tyr Asn Trp Leu 
            900                 905                 910         


Asp Asn Lys Leu His Phe Val His Leu Asn His Leu His His Leu Thr 
        915                 920                 925             


Ile Asp Ile Leu Gly Arg Met Ala Gly Phe Val Ala Leu Trp Glu Arg 
    930                 935                 940                 


Asp Phe Gln Tyr Ile Thr Lys Tyr Thr Ala Ala Lys Glu Gly Thr Asp 
945                 950                 955                 960 


Ala Leu Ser Phe Asp Gly Gly Leu Pro Arg Leu Lys Asp Lys Gln Glu 
                965                 970                 975     


Tyr Tyr Asn Lys Leu Phe Leu Ser Asp Lys Tyr Thr Lys Val Arg Asn 
            980                 985                 990         


His Ile Ala His Phe Asn Tyr Leu  Thr Lys Asp Ala Ala  Asp Phe Ala 
        995                 1000                 1005             


Leu Leu  Asp Leu Ile Asn Glu  Leu Arg Glu Leu Leu  His Tyr Gly 
    1010                 1015                 1020             


Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ala Phe Ile  Asp Leu Phe 
    1025                 1030                 1035             


Glu Lys  His Gly Met Ile Leu  Lys Leu Lys Leu Asn  Thr Asp His 
    1040                 1045                 1050             


Gln Leu  Val Val Glu Ser Ile  Glu Pro Lys Lys Ile  Tyr His Leu 
    1055                 1060                 1065             


Gly Ser  Thr Ala Lys Asp Lys  Pro Glu Tyr Gln Tyr  Thr Thr Asn 
    1070                 1075                 1080             


Gln Val  Met Thr Val Tyr Cys  Asn Met Cys Arg Ser  Leu Leu Glu 
    1085                 1090                 1095             


Met Lys  Lys 
    1100     


<210>  1066
<211>  931
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1066

Leu Lys Trp Arg Lys Asn Met Lys Leu Ser Lys Val Thr Tyr Arg Val 
1               5                   10                  15      


Lys Asp Lys Asn Ala Lys Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala 
            20                  25                  30          


Val Ala Asn Asn Ser Glu Asn Ala Gly Gly Val Leu Tyr His Val Pro 
        35                  40                  45              


Gly Val Asp Leu Ile Asp Leu Arg Glu Gln Met Leu Asp Arg Asp Arg 
    50                  55                  60                  


Ser Val Arg Leu Leu Tyr Asn Ile Phe Asn His Ile Gln Thr Gly Thr 
65                  70                  75                  80  


Lys Pro Lys Lys Trp Gly Asn Asp Glu Thr Leu Ser Val Asp Glu Asn 
                85                  90                  95      


Glu Arg Lys Ala Lys Glu Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp 
            100                 105                 110         


Arg Glu Ala Cys Ser Glu Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn 
        115                 120                 125             


Ser Val Leu Phe Tyr Ser Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg 
    130                 135                 140                 


Met Asn Asp Asn Glu Ala Ile Ile Val Lys Met Gln Tyr Glu Asn Arg 
145                 150                 155                 160 


Leu Ser His Phe Thr Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr 
                165                 170                 175     


Leu Arg Asn Ser Leu Val Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp 
            180                 185                 190         


Ser Val Asn Ala Met Val Val Phe Ile Asn Asn Ile Gly Asn Gly Asn 
        195                 200                 205             


Ile Ser Asp Lys Asp Lys Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile 
    210                 215                 220                 


Arg Asn Asp Phe Ser Lys Leu Asn Pro Asn Val Gln Ser Ser Gln Gly 
225                 230                 235                 240 


Ala Asn Met Val Arg Ser Val Arg Asn Gln Asn Met Val Val Gln Pro 
                245                 250                 255     


Gln Gly Asp Lys Val Ser Phe Pro Leu Val Ser Asp Glu Gly Lys Asn 
            260                 265                 270         


Thr Val Thr Asn Lys Asn Val Glu Lys Lys Gly Leu Asn Glu Phe Leu 
        275                 280                 285             


Leu Asn Tyr Ala Asn Leu Asp Asp Glu Glu Arg Met Glu Lys Leu Arg 
    290                 295                 300                 


Lys Leu Arg Arg Ile Ile Asp Val Tyr Phe Ser Ser Pro Ser His Tyr 
305                 310                 315                 320 


Gln Lys Asp Met Asp Ile Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys 
                325                 330                 335     


Phe Asp Val Trp Lys Lys His Glu Thr Gly Lys Lys Asn Thr Glu Leu 
            340                 345                 350         


Phe Val Asp Ile Pro Asp Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile 
        355                 360                 365             


Lys Leu Asp Ala Val Leu Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp 
    370                 375                 380                 


Ser Ile Arg Lys Gln Asn Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val 
385                 390                 395                 400 


Val Glu Lys Tyr Asn Ser Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser 
                405                 410                 415     


Ile Asn Gln Tyr Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile 
            420                 425                 430         


Leu Lys Ser Cys Lys Ala Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr 
        435                 440                 445             


Leu Thr Glu Lys Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys 
    450                 455                 460                 


Tyr Ile Ala Leu Gly Lys Val Ile Tyr Asn Phe Thr Val Asp Asp Ile 
465                 470                 475                 480 


Trp Lys Asp Lys Lys Val Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile 
                485                 490                 495     


Lys His Gly Ile Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu 
            500                 505                 510         


Ala Leu Gln Arg Glu Leu Ala Val Asn Val Ala Phe Ala Ala Asn Asn 
        515                 520                 525             


Leu Ala Arg Ala Val Cys Asp Met Thr Asn Leu Lys Asp Lys Glu Ser 
    530                 535                 540                 


Asp Phe Leu Ile Trp Asn Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn 
545                 550                 555                 560 


Lys Asp Asp Met Ala Ser Val Ser Val Val Leu Gln Phe Phe Gly Gly 
                565                 570                 575     


Lys Ser Ser Trp Asp Ile Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn 
            580                 585                 590         


Lys Tyr Asn Tyr Glu Val Cys Phe Ile Asp Asp Leu Arg Lys Ala Val 
        595                 600                 605             


Tyr Ala Ala Arg Asn Glu Ser Phe His Phe Lys Thr Ala Leu Val Asn 
    610                 615                 620                 


Asn Asp Ile Trp Asn Thr Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu 
625                 630                 635                 640 


Thr Glu Ile Cys Leu Asp Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn 
                645                 650                 655     


Leu Pro Val Phe Tyr Ser Asp Asn Asp Leu Lys Lys Met Leu Asp His 
            660                 665                 670         


Leu Tyr Asn Asn Lys Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn 
        675                 680                 685             


Ser Val Met Val Arg Lys Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu 
    690                 695                 700                 


Lys Tyr Gln Lys Pro Gly Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr 
705                 710                 715                 720 


Ser Ala Cys Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu 
                725                 730                 735     


Gln Ser Asp Glu Ala Leu Ala Leu Phe Glu Glu Ser Val Asn Asn Leu 
            740                 745                 750         


Lys Gly Asp Asn Lys Asp Gln Glu Leu Ala Val Lys Asn Phe Arg Asn 
        755                 760                 765             


Asn Tyr Lys Asn Ile Lys Ser Ser Cys Thr Ser Phe Ser Gln Val Cys 
    770                 775                 780                 


Gln Met Tyr Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys 
785                 790                 795                 800 


Val Arg Ser Ser Lys Asp Ser Ile Val Asp Lys Pro Ile Tyr Gln His 
                805                 810                 815     


Tyr Lys Leu Leu Leu Lys Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr 
            820                 825                 830         


Leu Gln His Asn Glu Glu Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys 
        835                 840                 845             


Val Asn Cys Leu Lys Glu Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp 
    850                 855                 860                 


Thr Ser Lys Lys Tyr Val Ser Leu Cys Glu Glu Val Arg Lys Ser Pro 
865                 870                 875                 880 


Glu Leu Gln Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ser Arg Ser 
                885                 890                 895     


Leu Asn Leu Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn 
            900                 905                 910         


Asp Ile Lys Arg Arg Ala Asp Gly Ile Gly Asn Glu Leu His Val Ile 
        915                 920                 925             


Ala Gln Asn 
    930     


<210>  1067
<211>  1391
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1067

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Lys Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Phe Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn Gln Ile Gln Thr Gly Thr Lys Pro Lys Glu Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Lys Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Ile Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Asn Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Val Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Phe Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Gln Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Glu Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Ala Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Lys Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Ser Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Leu Tyr Leu Gln Asn Asn Lys Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Met Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Cys Ile  Ser Ser Ile Lys Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Thr Leu Ile Thr Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Gly  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Gly Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Asn Lys Asn Lys Lys  Asn Lys Lys Asn Asn  Gly Asn Arg 
    1355                 1360                 1365             


Asp Glu  Lys Lys Asn Ser Asp  Gly Leu Thr Tyr Ser  Pro Phe Leu 
    1370                 1375                 1380             


Asp Leu  Pro Phe Glu Leu Pro  Glu 
    1385                 1390     


<210>  1068
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1068

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Asn Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Leu Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Val 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Val Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Val Lys Asp Asn Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Lys 
        915                 920                 925             


Lys Tyr Glu Lys Ala Ile Arg Asn Ile Gln Gln Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Ser Leu Leu Leu 
945                 950                 955                 960 


Arg Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Asn Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asp  Thr Glu Lys Ile Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Glu Leu  Lys Lys Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  Asn Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Ile Met Lys Ser  Ile Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Val Thr Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Glu Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Lys  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  1069
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1069

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Lys Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn Gln Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Ile Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Asn Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Val Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Phe Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Gln Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Lys Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ala Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asp Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Ile Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Met Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Glu  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Ala Gln Gly  Gly Ala Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Arg Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Lys Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Met Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Cys Ile  Ser Ser Ile Lys Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Thr Leu Ile Thr Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Ser Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Gly Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  1070
<211>  1287
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1070

Met Arg Ile Gly Lys Val Gln Gly Arg Thr Phe Thr Gly Phe Asp Asn 
1               5                   10                  15      


Ala Arg Gly Lys Thr Leu Arg Arg Arg Leu Leu Thr Arg Pro Asp Asn 
            20                  25                  30          


Glu Ala Arg Ser Leu Ser Glu His Leu Ala His Asp Pro Lys Ala Leu 
        35                  40                  45              


Ile Gly Gln Ala Ile Ser Arg Ile Asp Thr Ile Tyr Gln Lys Pro Lys 
    50                  55                  60                  


Thr Gly Lys Pro Thr Pro Glu Gln Phe Gly His Arg Asp Thr Leu Gly 
65                  70                  75                  80  


Trp Ala Tyr Trp Lys Leu Leu Val Ala Ser Tyr Pro Glu Val Glu Gly 
                85                  90                  95      


His Arg Asp Leu Phe Val Arg Arg Leu His Pro Tyr Gly Asp Thr Pro 
            100                 105                 110         


Pro Lys Ser His Gly Gln Lys Glu Gly Glu His Gln Lys Gly Gly Lys 
        115                 120                 125             


Pro Gln Leu Glu Gly Arg Trp His Gly Val Met Ala Gln His Gly Lys 
    130                 135                 140                 


Asn Pro Asp Gln Ile Ala Ala Arg Leu Phe Asp His Leu His Asn Ser 
145                 150                 155                 160 


Glu Leu Arg Phe Gly Gly Thr Ala Ser Gly Glu Pro Arg Thr Arg Pro 
                165                 170                 175     


Gly Lys Glu Ala Thr Pro Thr Gly Leu Ile Gly Ala Arg Ala Lys Thr 
            180                 185                 190         


Ile Glu His Ser Val Leu Pro Arg Asp Ala Lys Arg Phe Val Ala Glu 
        195                 200                 205             


Trp Arg Gly Glu Asp Gln Glu Arg Tyr Ala Gly Ala Arg Asp Ile Ala 
    210                 215                 220                 


Ala Ala Ile Ser Ala Gly Leu Asn Asp Lys Asp Gln Lys Ser Gly Ser 
225                 230                 235                 240 


Gly Arg Lys Ser Ala Val Ile Gly Lys Leu Leu Ser Asp His Leu Glu 
                245                 250                 255     


Thr Leu Thr Gly Asn Arg Lys Cys Arg Phe Asp Pro Lys Ser Thr Ala 
            260                 265                 270         


Glu Thr Leu Glu Leu Arg Asp Gly Glu Ser Val Asp Asp Arg Arg Arg 
        275                 280                 285             


Ile Leu Glu Leu His Ala Glu Val Lys Ala Thr Tyr Lys Arg Met Ala 
    290                 295                 300                 


Ala Trp Lys Pro Ala Lys Leu Pro Arg Asn Ser Asp Glu Leu Phe Arg 
305                 310                 315                 320 


Leu Val Arg Gln Gln Ala Asp Asn Arg Ile Leu Asn His Leu Val Arg 
                325                 330                 335     


Val Gly Arg Ile Ser Val Tyr Ser Glu Gln Ser Asp Ala Leu Ser Glu 
            340                 345                 350         


Ser Gln Phe Trp Thr Ser Gly Gly Gln Thr Gln Ile Lys Glu Ser Glu 
        355                 360                 365             


Val Phe Ala Arg Leu Trp Ile Gly Ala Ile Ser Arg Ala Ser Tyr Ser 
    370                 375                 380                 


Met Lys Ala Trp Leu Glu Pro Glu Gly Thr Val Phe Asn Pro Ser Ile 
385                 390                 395                 400 


Asn Asp Phe Asp Val Thr Ser Ser His Asn Thr Asn Arg Ile Leu Glu 
                405                 410                 415     


Asp Ser Gly Arg Leu Ser Asn Ala Met Ala Arg Arg Ala Ile Tyr Phe 
            420                 425                 430         


Gly Glu Thr Pro Glu Phe Asp Ala Leu Gly Glu Glu Asp Gln Arg Val 
        435                 440                 445             


Leu Val Lys Lys Cys Leu Asp Ala Leu Ser Ala Cys Arg Asn Arg Thr 
    450                 455                 460                 


Phe His His Gly Gln Arg Ala Lys Phe Leu Lys Glu Val Arg Lys Gly 
465                 470                 475                 480 


Leu Lys Glu Lys Glu Ala Asp Ser Ala Gly Pro Ala Ala Trp Glu Gly 
                485                 490                 495     


Ile Arg Glu Val Ile Gln Ala Asp Ala Arg Asn Leu Gly Ala Arg Leu 
            500                 505                 510         


Leu Gln Asp Leu Thr Gly Ala Lys Val His Ser Phe Ala Thr Asp Pro 
        515                 520                 525             


Glu Phe Arg His Leu Tyr Glu Ser Val Ala Ala Thr Leu Thr Ala Gly 
    530                 535                 540                 


Gly Glu Leu Glu Ala Ala Leu Pro Arg Leu Lys Asn Val Leu Lys Arg 
545                 550                 555                 560 


Ala Glu Gly Val Arg Cys Tyr Leu Asp Thr Pro Ser Gln Arg Arg Glu 
                565                 570                 575     


Gly Asp Glu Ser Leu Ile Ala Arg Leu Pro Val Ala Pro Val Pro Arg 
            580                 585                 590         


Glu Leu Asp Asp Ala Ala Thr Lys Ala Arg His Ser Ala Leu Leu Arg 
        595                 600                 605             


Leu Tyr Asp Gly Pro Phe Arg Pro Trp Ala Thr Glu Leu Arg Gly Glu 
    610                 615                 620                 


Arg Leu Ser Asp Tyr Ala Ala Arg Ala Lys Arg Leu Ala Thr Arg Leu 
625                 630                 635                 640 


Ala Lys Ser Thr Asn Thr Ala Ser Pro Tyr Pro Asp Ser Val Glu Gly 
                645                 650                 655     


Arg Ser Val Arg Leu Arg Asp Pro Ile Thr Ala Asp Thr Ala Pro Glu 
            660                 665                 670         


Thr Leu Lys Thr Tyr Leu Ser Ala Leu Thr Ala Glu Thr Ala Thr Glu 
        675                 680                 685             


Phe Arg Val Gln Lys Gly Tyr Glu Ser Asp Gly Glu Lys Ala Lys Glu 
    690                 695                 700                 


Gln Ala Glu Phe Ile Glu Asp Phe Arg Arg Asp Met Ile Ala Leu Ala 
705                 710                 715                 720 


Phe Gln Asp Phe Ile Arg Asp His Gly Phe Ala Trp Leu Leu Asp Ile 
                725                 730                 735     


Ala Ser Lys Ala Glu Pro Ser Asn Asp Ala Pro Asn Leu Pro Asp Pro 
            740                 745                 750         


Val Asp Thr Gly Lys Asp Thr Val Phe Glu Asp Trp Gln Ala Leu Leu 
        755                 760                 765             


Tyr Leu Phe Leu His Phe Val Pro Ala Asp Asp Val Ser Gln Leu Leu 
    770                 775                 780                 


His Gln Leu Arg Lys Trp Asp Ala Leu Gln Asp Lys Tyr Glu Leu Ala 
785                 790                 795                 800 


Glu Pro Gly Glu Thr Leu Gly Gln Thr Lys Ala Asp Thr Arg Lys Ile 
                805                 810                 815     


Val Gly Gln Phe Arg Asp Cys Leu Thr Leu Phe Leu Lys Thr Gly Asp 
            820                 825                 830         


Ala Arg Phe Asp Gly Glu Gly Val Glu Leu Pro Leu Ser Asp Phe Gln 
        835                 840                 845             


Glu Leu Phe Glu Ser Pro Ala Thr Phe Lys Glu Leu Phe Leu Ala Glu 
    850                 855                 860                 


Pro Ala Glu Asn Asp Ala Ser Glu Thr Asp Asp Gln Asp Ala Pro Gly 
865                 870                 875                 880 


Glu Lys His Arg Val Thr Arg Thr Arg Arg Gly Leu Arg Gln Ile Leu 
                885                 890                 895     


Arg Tyr Asn His Met Pro Val Leu Arg Asp Leu Phe Leu Ala His Lys 
            900                 905                 910         


Val Thr Asp Ala Glu Val Asp Gly Leu Gln Ala Leu Glu Val Asp Asp 
        915                 920                 925             


Pro Gln Thr Gly Glu Ser Gln Ile Gly Ala Ala Gln Arg Ile Arg Thr 
    930                 935                 940                 


Glu Ile His His His Thr Ser Asn Asp Lys Gln Ile Ser Glu Ala Lys 
945                 950                 955                 960 


Val Glu Glu Tyr Arg Arg Ala Leu Ser Thr Ile Glu Arg His Arg Phe 
                965                 970                 975     


Leu Val Gly Arg Val Tyr Leu Gly Asp His Ile Arg Val His Lys Leu 
            980                 985                 990         


Met Met Asp Val Met Gly Arg Leu  Val Asp Phe Ala Gly  Ala Trp Glu 
        995                 1000                 1005             


Arg Glu  Ala Ala Asp Gly Asp  Arg Lys Gly Phe Ile  Ser Arg Ala 
    1010                 1015                 1020             


Ile Ala  Leu Pro Glu Val Ala  Glu Gly Tyr Ala Ala  Asp Arg Leu 
    1025                 1030                 1035             


Lys Thr  Val Ala Arg Arg Val  Leu Asp Asp Gly Glu  Ala Arg Arg 
    1040                 1045                 1050             


Ile Arg  Asn Asp Leu Gly His  Phe Asn Asp Leu Ala  Pro Thr Ser 
    1055                 1060                 1065             


Gly Pro  Ala Asn Leu Thr Phe  Val Val Asn Arg Ala  Arg Arg Met 
    1070                 1075                 1080             


Met Arg  His Asp Arg Lys Arg  Lys Asn Ala Val Thr  Lys Ser Val 
    1085                 1090                 1095             


Ile Glu  Ile Leu Asn Arg Gln  Gly Leu Gly Ile Glu  Trp Thr Met 
    1100                 1105                 1110             


Arg Asn  His Glu Leu Cys Glu  Ala Lys Leu Trp Gln  Asn Pro Val 
    1115                 1120                 1125             


Lys His  Leu Gly Phe Ala Thr  Leu Glu Gly Arg Gly  Lys Lys Trp 
    1130                 1135                 1140             


Arg Arg  Pro Phe Glu Ala Arg  Tyr Gly Asp Ala Tyr  Met Ala Met 
    1145                 1150                 1155             


Val Ala  Gln Leu Phe Asp Gly  Thr Val Thr Ser Pro  Pro Ala Lys 
    1160                 1165                 1170             


Gly Pro  Pro Gln Ser Gly Lys  Ser Gly Gly Lys Pro  Gly Lys Gly 
    1175                 1180                 1185             


Ala Glu  Gly Gly Ala Lys Glu  Lys Ser Arg Ser Pro  Thr Arg Met 
    1190                 1195                 1200             


Glu Glu  Gly Gly Val Tyr Glu  Gly Arg Val Ala Lys  Ala Lys Ser 
    1205                 1210                 1215             


Asp Lys  Gly Phe Gly Phe Leu  Leu Val Glu Gly Ala  Gln Glu Glu 
    1220                 1225                 1230             


Ile Phe  Leu His Ile Tyr Gly  Ile Ser Gly Asn Arg  Pro Ala Arg 
    1235                 1240                 1245             


Ile Glu  Asn Gly Gln Arg Tyr  Arg Phe Thr Leu Gly  Ile Asp Arg 
    1250                 1255                 1260             


Asp Arg  Glu Arg Arg Lys Glu  Arg Ala Trp Val Ala  Arg Glu Ala 
    1265                 1270                 1275             


Val Arg  Ile Asp Glu Asn Arg  Ser Lys 
    1280                 1285         


<210>  1071
<211>  1373
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1071

Met Ala Lys His Leu Arg Pro Ile Gly Glu Ser Tyr Thr Asp Phe Leu 
1               5                   10                  15      


Asp Glu Thr Glu Phe Val Arg Leu Gly Arg Gly Leu His Arg Gly His 
            20                  25                  30          


His Gly Val Gln Ile Pro Pro Thr Glu Leu Pro Ser Tyr Leu Ala Glu 
        35                  40                  45              


Tyr Arg Lys Ala Leu Met Arg Gln Val Val Ala Val Leu Asp Lys Val 
    50                  55                  60                  


Val Gly Lys Arg Arg Arg Leu Ser Gly Met His Pro Glu Ala Tyr Arg 
65                  70                  75                  80  


Asp Arg Val His Leu Ala Glu Ala Leu Trp Val Arg Leu Val Ala Arg 
                85                  90                  95      


Val Lys Glu Ile Gly Thr Pro Pro Asp Pro Ser Glu Leu Leu Asp Leu 
            100                 105                 110         


Arg Arg Met Trp Asn Ala Lys Ala His Pro Tyr Ala Glu Tyr Asp Val 
        115                 120                 125             


Val Pro Arg Ala Pro Leu Asn Asp Gly Asn Gly Gln Lys Ile Leu Glu 
    130                 135                 140                 


Cys Arg Glu Val Asp Asp Pro Lys Ile Glu Arg Ser Asp Phe Glu Gly 
145                 150                 155                 160 


Arg Trp His Gly Arg Phe Trp Gln Ser Glu Pro Gly Pro Val Asp Tyr 
                165                 170                 175     


Asn Ala Ile Ala Asp Arg Ile Phe Ala His Leu Phe Asp Gln Glu Ala 
            180                 185                 190         


Val Ile Gly Gly Gly Pro Arg Arg Glu Gly Asn Val Thr Val Pro Asp 
        195                 200                 205             


Glu Asp Ile Asn Gly Gln Pro Gly Pro Ala Thr Gly Lys Gly Leu Ile 
    210                 215                 220                 


Ile Ala Arg Gly Gln Ser Ile Val Lys Ser Ala Ser Asp Pro Arg Arg 
225                 230                 235                 240 


Ser Ser Lys Lys Val Gln Arg Thr Trp Asp Lys Ala Val Glu Arg Arg 
                245                 250                 255     


Tyr Phe Gly Asp Asp Gly Lys Gly Gly Ser Asp Ile Ala Lys Ala Ile 
            260                 265                 270         


Tyr Glu Glu Leu Gly Asp Pro Ala Thr Leu Ala Asp Pro Ile Tyr Ala 
        275                 280                 285             


Ser Trp Phe Gly Ser Arg Leu Tyr Asp His Phe Gly Ser Phe Lys Asn 
    290                 295                 300                 


Ser Leu Pro Leu Glu Leu Lys Asp Pro Phe Lys Glu Gln Ile Trp Ala 
305                 310                 315                 320 


Leu His Asn Ser Val Arg Gln Phe Tyr Gln Arg Met Ala Lys Ser Asp 
                325                 330                 335     


Arg Phe Arg Leu Ala Leu Gln Asn Ala Arg Ser Glu Val Pro Asp Arg 
            340                 345                 350         


Ser Glu Leu Leu Ala Leu Leu Pro Lys Asp His Asp His Leu Leu Leu 
        355                 360                 365             


Val Leu Gly Gly Lys Lys Lys Asn Ala Glu Met Ser Glu Leu Ile Arg 
    370                 375                 380                 


Leu Gly Lys Leu Phe Val His Ala Ser Asp Val Leu His Asp Phe Asp 
385                 390                 395                 400 


Ala Asn Asp Ala Ala Ala Leu Asp Ala Phe Lys Arg Arg Met Ser Phe 
                405                 410                 415     


Leu Ala Thr Ser Ile Gly Gln Ser Glu Ile Lys Gln Thr Glu Thr Phe 
            420                 425                 430         


Ala Arg Thr Trp Arg Gly Ala Val Gly Leu Thr Leu Arg Thr Val Lys 
        435                 440                 445             


Gly Leu Ala Asp Pro Arg Gly Ile Ile Gly Thr Pro Asp Asn Arg Asp 
    450                 455                 460                 


Leu Gly Thr Ala Gly Pro Met Lys Asp Ala Phe Asn Lys Phe Asp Gln 
465                 470                 475                 480 


Pro His Phe Gln Gln His Met Thr Ile Ile Phe Gly Asn Lys Glu Leu 
                485                 490                 495     


Gln Ala Glu Gly Asn Pro Thr Arg Ser Ser Val Phe Thr Ala Asn Gly 
            500                 505                 510         


Asp Lys Asp His Gln Ala Glu Leu Leu Trp Gly Phe Leu Cys Val Val 
        515                 520                 525             


Arg Ser Val Arg Asn Arg Thr Asn His Tyr Asn Val Arg Arg Ala Leu 
    530                 535                 540                 


Leu Arg Leu Leu Asp Glu Gly Ile Val Ser Pro Met Pro Ser Asp Pro 
545                 550                 555                 560 


Lys Lys Glu Arg Val Glu Asn Arg Asn Leu Cys Thr Val Ser Pro Thr 
                565                 570                 575     


Ala Leu Glu Ala Phe Arg Arg Leu Leu Asn Phe Asp Leu Ala Ile Gln 
            580                 585                 590         


Lys Glu Ala Val Arg Thr Ala Leu Glu Gln Ala Lys Ala Ser Glu Phe 
        595                 600                 605             


Val Glu Glu Gly Lys Leu Arg Gly Leu Val Ser Glu Leu Ala Gly Thr 
    610                 615                 620                 


Glu Asp Met Pro Ala Leu His Ile Pro Arg Phe Ser Ala Val Met Asp 
625                 630                 635                 640 


Lys Val Arg Arg Leu Ala Asp Asn Arg Asp Val Gly Leu Asp Pro Ile 
                645                 650                 655     


Leu Ser Thr Leu Gln Arg Ser Leu Pro Pro Thr Asp Lys Gln Ala Glu 
            660                 665                 670         


Ser Asp Ala Ala Arg Cys Arg Tyr Arg Leu Leu Leu Glu Leu Tyr Lys 
        675                 680                 685             


Ser Gly Phe Arg Ser Trp Phe Ser Gly Ile Gln Ser Asn Glu Glu Asn 
    690                 695                 700                 


Asn Arg Glu Ile Cys His Trp Ala Val Lys Gln Val Gly Arg Ala Lys 
705                 710                 715                 720 


Asp Ala Arg Lys Ser Glu Tyr Asp Lys Lys Thr Lys Arg His Tyr Arg 
                725                 730                 735     


Ser Pro Asn Ser Leu Ile Asp Asp Leu Gly Leu Asp Lys Phe Asp Asp 
            740                 745                 750         


Leu Thr Asp Leu Leu Glu Ala Leu Ala Ser Gln Ser Thr Arg Glu His 
        755                 760                 765             


Asp Gln Asn Leu Lys Tyr Val Pro Asp Ala Arg Val Gln Ser Gln Met 
    770                 775                 780                 


Ser Asn Arg Ile Glu Glu Phe Arg Gln Glu Leu Phe Ala His Ile Phe 
785                 790                 795                 800 


Thr Lys Tyr Leu Asp Thr His Asp Phe Gly Trp Ile Gly Ala Ile Glu 
                805                 810                 815     


Val Arg Arg Glu Ala Cys Asp Leu Ala Asp Val Val Ser Ala Phe Glu 
            820                 825                 830         


Val Arg Asp Gln Lys Phe Asp Ala Asp Trp His Ser Gln Phe Tyr Ala 
        835                 840                 845             


Trp Leu Tyr Met Val Pro Pro Ile Glu Ala Ser Arg Leu Arg His Gln 
    850                 855                 860                 


Met Arg Lys Ser Ala Val Met Asp Asp Lys Trp Ser Thr Thr Leu Glu 
865                 870                 875                 880 


Leu Thr Ser Gly Asp Arg Lys Thr Arg Asp Asp His Ala Gln Asp Val 
                885                 890                 895     


Leu Ala Asp Met Asp Arg Leu Phe Ser Leu Tyr Thr Lys Val Gln Ala 
            900                 905                 910         


Ala Gly Phe Asn Gly Gln Glu His Glu Ser Ala Leu Gly Ser Lys Ser 
        915                 920                 925             


Leu Phe Tyr Glu Asp Gly Asn Gln Phe Asp Glu Val Tyr Ser Pro Asp 
    930                 935                 940                 


Thr Glu Thr His Asn Lys Thr Phe Pro Gly Thr Arg Arg Gly Leu Arg 
945                 950                 955                 960 


Gln Leu Val Arg Tyr Ala His Leu Pro Ala Leu Glu Gly Val Phe Lys 
                965                 970                 975     


Lys His Arg Ile Thr Lys Ala Glu Val Glu Thr Phe Val Ala Leu Tyr 
            980                 985                 990         


Asp Glu Asn Arg Arg Asp Pro Gly  Ser Val Ala His Met  Leu Arg Arg 
        995                 1000                 1005             


Glu Lys  Leu Arg Thr Glu Ile  Leu Arg Ser Ile His  Asp Gly Pro 
    1010                 1015                 1020             


Lys Pro  Lys Asp Lys Asp Phe  Trp Pro Lys Leu Glu  Ala Lys Cys 
    1025                 1030                 1035             


Leu Glu  Tyr Arg Thr Val Ala  Thr Glu Thr Ala Ile  Tyr Asn Phe 
    1040                 1045                 1050             


Gln Ala  Asn Ala Ala Arg Leu  Asn Asp His Ala Arg  Leu His Gln 
    1055                 1060                 1065             


Ile Val  Met Arg Val Val Ala  Arg Leu Thr Asp Tyr  Ala Leu Ile 
    1070                 1075                 1080             


Trp Glu  Arg Asp Arg Leu Phe  Ala Phe Val Gly Met  Leu Tyr Arg 
    1085                 1090                 1095             


Gln Thr  Gly Gly Thr Gly Ile  Asn Pro Ala Met Arg  His Ala Glu 
    1100                 1105                 1110             


Lys Thr  Asn Ala Pro Pro Arg  Ile Gly Ile Leu Val  Ser Asp Ser 
    1115                 1120                 1125             


Ala Leu  Ala Lys Lys Leu Asn  Ser Asn Ser Ala Glu  Val Phe Ile 
    1130                 1135                 1140             


Pro Tyr  Leu Asp Thr Glu Thr  Gly Phe Asp Ala Pro  Arg Phe Asp 
    1145                 1150                 1155             


Asp Leu  Cys Thr Leu Leu Ser  His Glu His Ala Lys  Glu Phe Arg 
    1160                 1165                 1170             


Phe His  Phe Leu Glu Val Gly  Glu Glu Asn Ser Lys  Asp Glu Ala 
    1175                 1180                 1185             


Arg Arg  Leu Asn Glu Glu Thr  Met Gly His Arg Lys  Arg Pro Ala 
    1190                 1195                 1200             


Phe Lys  Arg Gly Thr Arg Arg  Gln Gly Ile Arg Asn  Asp Leu Ala 
    1205                 1210                 1215             


His His  Asn Val Leu Asp Leu  Ala Gly Gly Ala Gly  Pro Asn Leu 
    1220                 1225                 1230             


Thr Tyr  Val Val Asn Ala Val  Arg Ser Leu Leu Ser  Tyr Asp Arg 
    1235                 1240                 1245             


Lys Leu  Lys Asn Ala Val Pro  Lys Ser Ile Lys Arg  Ile Leu Gly 
    1250                 1255                 1260             


Glu Glu  Gly Leu Ile Ile Glu  Trp Gln Met Asn Tyr  Asp Arg Leu 
    1265                 1270                 1275             


Lys Lys  Pro Thr Val Tyr Pro  Asn Val Glu Thr His  Leu Thr Met 
    1280                 1285                 1290             


Val Pro  Pro Arg His Met Thr  Ala Pro Val Ser Phe  Thr Leu Pro 
    1295                 1300                 1305             


Arg Ala  Ser Val Arg Leu Ala  Ser Met Val Lys Ala  Val Phe Asp 
    1310                 1315                 1320             


Phe Gly  Ser Ser Gly Tyr Gly  Glu Glu Arg Met Ile  Gly Gly Arg 
    1325                 1330                 1335             


Thr Ala  Lys Gln Ala Val Tyr  Pro Asp Asp Phe Thr  Arg Arg Phe 
    1340                 1345                 1350             


Pro Gln  Thr Pro Met Gly Leu  Lys Gln Ala Thr Arg  Leu Val Phe 
    1355                 1360                 1365             


Ala Ser  Glu Asn Ser 
    1370             


<210>  1072
<211>  1113
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1072

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Pro Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Lys Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Asp Ile Gln Lys Ile Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Lys Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Cys Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Thr Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Phe 
                325                 330                 335     


Asn Gly Leu Glu Glu Leu Glu Asn Leu Ser Gln Gln Lys Lys Glu Lys 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Arg Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Cys Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Lys 
                405                 410                 415     


Arg Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Ala Leu Glu Gly Glu Ser 
    450                 455                 460                 


Val Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Glu Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Ala Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Leu Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Arg Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Lys Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Lys Gly Asp Lys Glu Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Glu Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Ser Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Lys Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Ala Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Val Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Glu Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Met Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ile Gly  Arg Ala Ser Cys Arg  Glu Arg Val 
    1100                 1105                 1110             


<210>  1073
<211>  1386
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1073

Val Gly Glu Gln Gln Tyr Asp Gly Thr Arg Gly Ile Val Tyr Tyr Asp 
1               5                   10                  15      


Pro Ser Gln Gly Val Glu Leu Gly Asn Asn Tyr Leu Arg Arg Asp Gly 
            20                  25                  30          


His Ile Gly Asn Ser Leu Pro Asp Val Lys Gln Leu Val Lys Lys Arg 
        35                  40                  45              


Ser Asp Glu Ser Ala Asn Leu Tyr Ser Val Leu Asn Arg Asn Thr Val 
    50                  55                  60                  


Ile Phe Thr Lys Asp Lys Asn Lys Gln Lys Val Ile Lys Arg Ile Ile 
65                  70                  75                  80  


Asn Asp Phe Ser Ser Ile Phe Thr Gly Asn Gly Lys Lys Asp Gln His 
                85                  90                  95      


Leu Leu Phe Asn Gly Val Asn Val Cys Asp Tyr Asn Ala Val Ser Gln 
            100                 105                 110         


Tyr Met Lys Cys Glu Glu Lys Pro Asp Ile Asp Ser Leu Gly Tyr Glu 
        115                 120                 125             


Ser Asp Glu Lys Leu Ala Gln Asp Ile Val Ala His Ala Leu Arg Asn 
    130                 135                 140                 


Ser Leu Arg Arg Lys Ile Val Trp Lys Lys Lys Ala Tyr Tyr Leu Pro 
145                 150                 155                 160 


Asp Ile Ala Val Lys Leu Leu Leu Ala Val Gly Ile Arg Ala Asp Lys 
                165                 170                 175     


Glu Glu Tyr Lys Leu Ile Pro Arg Glu Glu Val Leu Ala Phe Val Gly 
            180                 185                 190         


Tyr Val Arg Val Asp Arg Ile Asn Lys Gln Ser Arg Trp Lys Asn Gly 
        195                 200                 205             


Asn Lys Ile Thr Arg Gln Glu Asp Met Val Ala Ser Ile Arg Lys Lys 
    210                 215                 220                 


Asp Val Lys Val Gln Val Phe Asp Lys Ala Gly Lys His Met Leu Met 
225                 230                 235                 240 


Leu Ser Asn Ser Glu Asn Val Lys Lys Arg Tyr Val Ala Asp Phe Leu 
                245                 250                 255     


Lys Ser Phe Ala Val Cys Ala Asp Glu Gly Glu Gln Asn Gln Met Ile 
            260                 265                 270         


Phe Gln Ile Arg Arg Leu Ile Val Leu Phe Val Tyr Gly Ser Asn Gln 
        275                 280                 285             


Tyr Ala Ala Phe Ser Asp Lys Asn Pro Trp Gly Lys Ile Pro Gly Leu 
    290                 295                 300                 


Gly Glu Lys Ala Asp Ile Phe Gly Asp Ile Leu Glu Lys Asp Asn Met 
305                 310                 315                 320 


Gly Asn Ile Ile Ala Arg Lys Val Ile Thr Glu Asp Thr Phe Thr Glu 
                325                 330                 335     


Ile Ala Asn Ser Lys Gly Lys Glu Ser Asn Arg Ala Val His Leu Asp 
            340                 345                 350         


Phe Asp Ala Lys Ile Arg Gln Ile Met Ile Ser His Tyr Lys Ala Ala 
        355                 360                 365             


Glu Ser Lys Ile Ile Glu Glu Lys Gly Ile Glu Asp Ser Gly Asp Ser 
    370                 375                 380                 


Leu Phe Trp Ile Ser His Phe Glu Thr Val Val Glu Gln Phe Val Lys 
385                 390                 395                 400 


Ile Arg Lys Lys Arg Lys Phe Asn Asp Tyr Arg Cys Val Arg Ile Cys 
                405                 410                 415     


Asn Met Leu Trp Glu Glu Trp Leu Ser Tyr Ile Ala Leu Lys Tyr Met 
            420                 425                 430         


Asp Leu Gly Lys Ala Val Tyr Tyr Phe Gly Thr Pro Asp Leu Tyr Ala 
        435                 440                 445             


Leu Asp Ser Arg Gln Pro Val Lys Ile Gly Pro Val Gln Glu Arg Tyr 
    450                 455                 460                 


Ala Asp Gly Leu Thr Ser Phe Asp Tyr Glu Lys Ile Lys Ala Glu Glu 
465                 470                 475                 480 


Thr Leu Val Arg Asn Phe Ala Thr Ala Val Thr Phe Ala Glu Asn Ala 
                485                 490                 495     


Phe Ser Asn Ala Val Val Arg Glu Glu Tyr Arg Leu Gly Phe Asp Lys 
            500                 505                 510         


Arg Glu Gly Asp Arg Ala Asp Val Leu Gly Tyr Ser Asp Ser Gln Phe 
        515                 520                 525             


Lys Asp Lys Asp Ile Ile Asn Glu Asn Ala Trp Lys Arg Val Met Gly 
    530                 535                 540                 


Tyr Phe Gly Gly Ala Ala Ile Trp Lys Asp Met Lys Ile Asn Gly Ser 
545                 550                 555                 560 


Gly Glu Gln Glu Pro Lys Phe Leu Asn Glu Ile Arg Lys His Ile Ala 
                565                 570                 575     


Asn Ile Arg Asn Ala Asn Phe His Phe Ser Thr Asp Arg Asn Pro Ile 
            580                 585                 590         


Leu Ser Asp Asn Asn Thr Tyr Ala Lys Lys Leu Phe Ser Gly Glu Tyr 
        595                 600                 605             


Gly Arg Ile Asn Gln Leu Ile Gly Glu Lys Tyr Leu Ser Asn Asn Ile 
    610                 615                 620                 


Leu Ala Phe Tyr Pro Ala Ala Ser Ser Val Glu Gly Met Glu Thr Gly 
625                 630                 635                 640 


Leu Tyr Pro Leu Met Lys Lys Leu Tyr Cys His Val Val Glu Arg Glu 
                645                 650                 655     


Ala Gln Ile Pro Ala Phe Asn His Ile Ile Lys Lys Lys Asp Val Arg 
            660                 665                 670         


Val Phe Val Glu Glu Phe Leu Leu Lys Asp Glu Ser Val Lys Asn Lys 
        675                 680                 685             


Ser Val Lys Asn Ser Ile Phe Ser Asp Thr Lys Leu Thr Asp Lys Tyr 
    690                 695                 700                 


Leu Ser Gly Leu Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Tyr Gly Phe 
705                 710                 715                 720 


Leu Ser Glu Asn Asp Leu Met Val Lys Phe Asp Asn Ala Leu Lys Gln 
                725                 730                 735     


Ile Lys Asn Lys Val Asp Glu Glu Asn Asp Lys Leu Lys Lys Glu Lys 
            740                 745                 750         


Asp Ser Lys Asp Thr Ser Glu Lys Lys Ala Met Asn Asn Phe Ile Lys 
        755                 760                 765             


Arg Tyr Asp Glu Ile Lys Asp Lys Met Thr Phe Gly Gln Met Cys Gln 
    770                 775                 780                 


Gln Ile Met Thr Asp Tyr Asn Met Gln Asn Gln Lys Gln Lys Glu Val 
785                 790                 795                 800 


Pro Ser Thr Ala Lys Ser Lys Trp Asn Ala Gln Asn Gly Asn Lys Pro 
                805                 810                 815     


Leu Tyr Lys His Tyr Val Leu Ile Leu Gln Gln Cys Ile Arg Arg Ala 
            820                 825                 830         


Phe Glu Glu Tyr Leu Asp Ser Asp Glu Val Phe Gly Phe Leu Lys Val 
        835                 840                 845             


Pro Lys Ile Phe Gln Ala Asp Phe Glu Ala Glu Leu Ile Ser Lys Glu 
    850                 855                 860                 


Lys Ala Glu Glu Phe Ile Arg Asn Ile Pro Ser Gly Ile Cys Leu Phe 
865                 870                 875                 880 


Glu Lys Val Ala Val Met Gly Lys Glu Ile Glu Gln Lys Lys Asp Lys 
                885                 890                 895     


Val Asn Ile Arg Gln Asp Ile Gln Leu Met Tyr Asp Trp Tyr Val Thr 
            900                 905                 910         


Ala His Phe Met Ser Ala Lys Gln Ile Asn Met Leu Ile Gly Asp Ile 
        915                 920                 925             


Arg Ser Tyr Lys Gln Tyr Val Asn Asn Ile Tyr Glu Arg Ala Lys Asn 
    930                 935                 940                 


Thr Gly Asn Thr Thr Ala Ala Asp Arg Ile Leu Asp Thr Ser Leu Val 
945                 950                 955                 960 


Ser Arg Tyr Ser Asp Ile Leu Ser Val Leu Glu Phe Val Leu Gln Phe 
                965                 970                 975     


Val Gly Lys Thr Ser Arg Asn Ile Glu Asp Tyr Phe Asp Thr Gln Glu 
            980                 985                 990         


Glu Tyr Ala Lys Tyr Ile Ala Asn  Tyr Val Asp Phe Asp  Ala Phe Leu 
        995                 1000                 1005             


Gly Glu  Ala Asp Ser Glu Gly  Asn Lys Tyr Lys Ala  Ala Leu Gln 
    1010                 1015                 1020             


Glu Phe  Cys Arg Gln Met Val  Glu Ser Ala Lys Ser  Thr Asp Lys 
    1025                 1030                 1035             


Ala Leu  Gly Ile Tyr Tyr Asp  Val Lys Asn Pro Val  Pro Asn Arg 
    1040                 1045                 1050             


Asn Met  Val Tyr Ser Leu Leu  Tyr Gly Asp Lys His  Met Leu Ser 
    1055                 1060                 1065             


Ala Val  Met Lys Lys Val Arg  Glu Asn Gly Thr Phe  Arg Ile Thr 
    1070                 1075                 1080             


Gln Glu  Glu Ile Val Gln Tyr  Tyr Glu Met Arg Asn  Gln Leu Ser 
    1085                 1090                 1095             


Ser Val  Phe Lys Arg Gly Ser  Cys Ile Ser Asp Asp  Glu Gln Lys 
    1100                 1105                 1110             


Leu Leu  Lys Glu Phe Gln Asn  Leu Lys Asn Arg Ile  Glu Leu Leu 
    1115                 1120                 1125             


Asp Ile  Gln Thr Tyr Thr Glu  Leu Leu Asn Asp Ile  Met Ala Gln 
    1130                 1135                 1140             


Met Val  Ser Trp Ala Tyr Leu  Arg Glu Arg Asp Leu  Met Tyr Tyr 
    1145                 1150                 1155             


Gln Leu  Gly Tyr His Tyr Val  Arg Leu Phe Tyr Thr  Asp Lys Val 
    1160                 1165                 1170             


Thr Glu  Ala Lys Tyr His Thr  Leu Arg Gly Asp Lys  Ile Asn Ile 
    1175                 1180                 1185             


Glu Glu  Gly Ala Leu Leu Tyr  Gln Ile Ile Ala Leu  Tyr Asp His 
    1190                 1195                 1200             


Met Leu  Pro Leu Tyr Gly Val  Asp Lys Glu Gly Lys  Ala Phe Val 
    1205                 1210                 1215             


Ala Leu  Lys Arg Gly Thr Pro  Gly Lys Gly Met Thr  Pro Phe Met 
    1220                 1225                 1230             


Lys Glu  Tyr Cys Gln Glu Lys  Asp Thr Asn Asn Pro  Tyr Val Tyr 
    1235                 1240                 1245             


Tyr Gly  Gly Ile Arg Leu Phe  Glu Asp Lys Asp Lys  His Asp Lys 
    1250                 1255                 1260             


Phe Val  Phe Leu Arg Asp Tyr  Ile Ala His Met Lys  Tyr His Thr 
    1265                 1270                 1275             


Leu His  Asp Lys Ser Ile Trp  Asp Leu Phe Gly Glu  Met Tyr Asn 
    1280                 1285                 1290             


Gly Phe  Leu Arg Tyr Asp Thr  Lys Leu Lys Lys Ser  Val Ser Tyr 
    1295                 1300                 1305             


Ile Ser  Lys Asn Ile Leu Glu  Arg Tyr Phe Val Val  Leu Asn Thr 
    1310                 1315                 1320             


Ser Met  Glu Gln Gly Lys Gly  Ser Val Arg Gly Thr  Val Phe Ser 
    1325                 1330                 1335             


Val Glu  Lys Ile Thr Ser Asp  Thr Phe Thr Tyr Lys  Tyr Lys Asp 
    1340                 1345                 1350             


Gly Asn  Lys Lys Glu His Arg  Val Glu Val Pro Cys  Arg Ser Asp 
    1355                 1360                 1365             


Ile Phe  Leu Lys Gln Leu Glu  Glu Leu Leu Ala Tyr  Lys Arg Lys 
    1370                 1375                 1380             


Arg Leu  Ile 
    1385     


<210>  1074
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1074

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Ser Gly Ile Ser 
1               5                   10                  15      


Val Thr Glu Asn Lys Asn Glu Glu Gln Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Lys Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Lys Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Cys Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Thr Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Phe Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Val Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Met Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Phe 
                325                 330                 335     


Asn Gly Leu Glu Glu Leu Glu Asn Leu Ser Gln Gln Lys Lys Glu Lys 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Asn Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Arg Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Glu 
                405                 410                 415     


Arg Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Ala Leu Glu Gly Gly Ser 
    450                 455                 460                 


Val Ser Ile Cys Glu Val Lys Pro Glu Tyr Lys Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Val Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Ala Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Asp Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Glu Lys Gln Arg Ala Trp Glu Ser 
        755                 760                 765             


Phe Glu Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Val Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Ser Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Glu Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Arg Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Val Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Ser Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Glu Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Thr Gln  
    1355                 1360 


<210>  1075
<211>  1184
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1075

Met Arg Val Ser Lys Val Lys Val Leu Gly Asn Glu Glu Thr Lys Gly 
1               5                   10                  15      


Arg Ile Val Leu Met His Arg Ser Pro Val Lys Gly Gln Leu Ile Tyr 
            20                  25                  30          


Ser Glu Asp Ala Gly Lys Arg Asp Arg Thr Glu Asp Ile Ile Pro Glu 
        35                  40                  45              


Gln Lys Leu Glu Ser Phe His Leu Ser Ile Leu Asn Lys Thr Phe Leu 
    50                  55                  60                  


Arg Lys Glu Phe Phe Lys Lys Glu Leu Lys His Glu Ala Lys Lys Asn 
65                  70                  75                  80  


Gly Leu Lys Gly Asp Ala Glu Asp Lys Tyr Ile Ser Glu Lys Leu Lys 
                85                  90                  95      


Glu Tyr His Ser Leu Leu Gln Phe Ile Asp Asp Val Leu Ser Val Lys 
            100                 105                 110         


Tyr Asn Glu Asn Arg Lys Ala Ile Lys Phe Pro Glu Tyr Leu Thr Arg 
        115                 120                 125             


Glu Met Ile Glu Ile Phe Leu Asn His Lys Phe Arg Lys Glu Val Thr 
    130                 135                 140                 


Tyr Thr Asn Lys Asn Gly Ala Ser Val Ser Phe Leu Leu Ser Thr Leu 
145                 150                 155                 160 


Ile Leu Asn Ala Ile Glu Lys His Ser Val Ile Glu Met Gln Pro Phe 
                165                 170                 175     


Val Asp Trp Arg Asn Trp Phe Val Glu Thr Lys Ser Lys Phe Leu Lys 
            180                 185                 190         


Lys Ser Ile Ile Asn Asn Cys Ile Pro Thr Asn Gly Gly Pro Ile Ser 
        195                 200                 205             


Arg Arg Arg Glu Thr Leu Met Lys Trp Arg Asp Asp Tyr Phe Thr Asn 
    210                 215                 220                 


Ala Glu Ile Asp Leu Ala Arg Leu His Lys Lys Phe Gly Thr Asp Thr 
225                 230                 235                 240 


Leu Met Ala Ser Leu Arg Glu Val Pro Gln Thr Glu Lys Ser Gly Asn 
                245                 250                 255     


Glu Tyr His Arg Leu Leu Lys Ser Cys Leu Gln Ser His Gln Lys Lys 
            260                 265                 270         


Leu Phe Gly Lys Arg Ala Glu Gly Tyr Asp Ile Asn Arg Ala Asp Asn 
        275                 280                 285             


Gln Leu Tyr Val Tyr Asn Thr Glu Val Val Lys Tyr Met Glu His Tyr 
    290                 295                 300                 


Phe Pro Val Lys Ser Ser Lys Arg Arg Asn Ser Thr Ala Glu Ile Lys 
305                 310                 315                 320 


Tyr Tyr Leu Gln Thr Asp Thr Ile Lys Cys Cys Leu His His Gln Ile 
                325                 330                 335     


Ile Asn Ala Val Arg Gly Leu Ala Leu Arg Glu Gly Lys Phe Asn Leu 
            340                 345                 350         


His Gly Phe Asp Asp Lys Leu Ile Pro Asn Glu Arg Asn Val Ser Ser 
        355                 360                 365             


Ser Ile Leu Asn Glu Leu Lys Thr Ser Glu Gly Phe Val Leu Asn Met 
    370                 375                 380                 


Leu Gly Gly Cys Ala Phe Ala Ala Asn Cys Leu Arg Asn Ile Val Asp 
385                 390                 395                 400 


Ala Thr Gln Arg Ser Asp Leu Leu Gly Phe Arg Cys Phe Glu Val Ser 
                405                 410                 415     


Leu Lys Lys Gly Lys Ser Asn Ser Asp Leu Phe Ala Leu Phe Phe Gly 
            420                 425                 430         


Phe Gly Arg Glu Asp Met Asp Asp Asp Ser Glu Trp Glu Lys His Leu 
        435                 440                 445             


Tyr Ala Ala Arg Tyr Ser Val Ser Glu Ile Arg Asn Arg Val Ala His 
    450                 455                 460                 


Tyr His Lys Ser Ala Ile Glu Asn Ile Tyr Asn Ile Thr Asp Phe Glu 
465                 470                 475                 480 


Tyr Arg Glu Asn Ser Met Cys Ser Tyr Thr Asp Thr Lys Phe Thr Thr 
                485                 490                 495     


Ala Leu Gln Asn Glu Ile Tyr Asn Thr Pro Lys Ala Phe Ser Leu Gln 
            500                 505                 510         


Leu Met Thr Gly Lys Val Leu Glu Tyr Tyr Pro Lys Glu Lys Leu Val 
        515                 520                 525             


Ser Phe Phe Gln Lys Tyr Lys Phe Ser Leu Tyr Arg Ser Val Val Pro 
    530                 535                 540                 


Phe Ala Pro Gly Phe Lys Asn Ile Met Arg Thr Gly Val Asn Tyr Gln 
545                 550                 555                 560 


Asn Ala Thr Gln Asn Arg Leu Phe Tyr Asp Met Gly Leu Thr Ala Phe 
                565                 570                 575     


Gln Asp Lys Asp Arg Tyr Ile Asp Asp Val Glu Ala Trp Asn Ala Arg 
            580                 585                 590         


Tyr Phe Phe Met Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Arg Phe 
        595                 600                 605             


Thr Asn Asp Lys Asn Asp Leu Phe Arg Lys Thr Val Glu Gln Val Leu 
    610                 615                 620                 


Glu Val Asn Arg Ser His Met Glu Lys Val Gly Lys Asp Asp Arg Gln 
625                 630                 635                 640 


Ala Phe Gly Glu Val Arg Gln Met Arg Glu Asn Glu Thr Ala Asn Asp 
                645                 650                 655     


Tyr Met Ala Tyr Leu Gln Ser Ser Leu Arg Met Glu Lys Asn Lys Lys 
            660                 665                 670         


Glu Leu Glu Gly Asn Gly Ala Lys Arg Ile Asn Phe Glu Lys Phe Ile 
        675                 680                 685             


Leu Gln Met Phe Val Lys Gly Phe Asp Ser Phe Leu Lys Asp Gly Ala 
    690                 695                 700                 


Phe Glu Phe Val His Ser Pro Glu Asn Cys Leu Thr Gly Ser Thr Glu 
705                 710                 715                 720 


Lys Glu Arg Ala Lys Glu Arg Asn Ser Leu Cys Glu Glu Ile Gly Asn 
                725                 730                 735     


Tyr Val Arg Leu Val Ser Thr Val Ile Asp Pro Gly Lys Gly Ser His 
            740                 745                 750         


Val Ala Phe Tyr Val Phe Cys Lys Met Leu Asn Ser Val Tyr Leu Ser 
        755                 760                 765             


Asn Ile Arg Asn Glu Met Ile Lys Tyr His Lys Val Val Arg Thr Asp 
    770                 775                 780                 


Glu Leu Ala His Leu Ile Glu Ile Ile Glu Leu Cys Leu Leu Ser Ala 
785                 790                 795                 800 


Asp Ala Val Ser Gln Lys Thr Val Asn Ala Asp Lys Leu Ser His Phe 
                805                 810                 815     


Phe Ala Glu Gly Val Asn Val Asp Asp Asp Glu Asn Val Ile His Ala 
            820                 825                 830         


Ser Met Glu Thr Phe Arg Lys Tyr Gly Thr Arg Asp Leu Phe His Lys 
        835                 840                 845             


Leu Met Leu Gln Asp Asp Arg Phe Leu Val Ser Ser Asp Asp Tyr Arg 
    850                 855                 860                 


Glu Trp Glu Glu Met Lys Glu Lys Ile Glu Gly Lys Val Lys Gln Arg 
865                 870                 875                 880 


Glu Leu Leu His Ala Glu Trp Cys Glu Ala Lys Glu Lys Asp Lys Lys 
                885                 890                 895     


Ser Arg Lys Val Lys Ser Asn Ser Arg Thr Cys Phe Glu Lys Lys Phe 
            900                 905                 910         


Met Gly Ala Lys Ala Glu Glu Tyr Tyr Ser Leu Cys Asn Val Ile Asp 
        915                 920                 925             


Lys Tyr Asn Trp Leu Asp Asn Lys Leu His Leu Val His Leu Asn Lys 
    930                 935                 940                 


Leu His Asn Leu Val Ile Glu Ile Leu Gly Arg Met Val Gly Phe Thr 
945                 950                 955                 960 


Ala Leu Phe Glu Arg Asp Phe Gln Tyr Ile Cys Lys Ser Asp Ser Glu 
                965                 970                 975     


Tyr Glu Gln Leu Tyr Asn Leu Asp Phe Asn Met Gly Leu Pro Lys Phe 
            980                 985                 990         


Lys Asn Ser Ile Lys Gly Ser Gly  Lys Ala Lys Asn Ser  Thr Gln Asn 
        995                 1000                 1005             


Ile Asp  His Asn Ala Thr Gly  Ile Gly Asn Ser Ser  Asn Leu Leu 
    1010                 1015                 1020             


Lys Glu  Asn Ser Asn Gly Thr  His Tyr Cys Lys Asn  Leu Ser Gly 
    1025                 1030                 1035             


Asp Gly  Val Glu Asp Lys Leu  Lys Arg Leu Phe Leu  Tyr Asp Asp 
    1040                 1045                 1050             


Tyr Arg  Asn Val Arg Asn Phe  Val Ala His Phe Asn  Tyr Leu Thr 
    1055                 1060                 1065             


Arg Val  Glu Asp Asp Leu Gly  Gly Asn Asp Ala Val  Lys Leu Ser 
    1070                 1075                 1080             


Gly Thr  Arg Tyr Ser Leu Ile  Glu Leu Ile Asn Glu  Leu Arg Asn 
    1085                 1090                 1095             


Leu Leu  Lys Tyr Asp Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ser 
    1100                 1105                 1110             


Phe Ile  Asp Met Phe Glu Arg  His Gly Met His Val  Lys Met Lys 
    1115                 1120                 1125             


Leu Asn  His Asn His Lys Leu  Phe Val Asp Ser Ile  Ser Pro Arg 
    1130                 1135                 1140             


Lys Ile  Lys His Leu Gly Gly  Gly Tyr Lys Lys Arg  Gly Lys Asp 
    1145                 1150                 1155             


Asp Lys  Met Tyr Val Gln Thr  Thr Asn His Val Asp  Pro Leu Tyr 
    1160                 1165                 1170             


Cys Asp  Met Cys Arg Ala Leu  Leu Glu Met Lys 
    1175                 1180                 


<210>  1076
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1076

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Lys Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Phe Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn Gln Ile Gln Thr Gly Thr Lys Pro Lys Glu Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Lys Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Ile Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Asn Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Val Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Phe Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Gln Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Lys Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ala Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asp Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Ile Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Met Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Glu  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Ala Gln Gly  Gly Ala Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Arg Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Lys Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Met Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Cys Ile  Ser Ser Ile Lys Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Thr Leu Ile Thr Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Ser Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Gly Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  1077
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1077

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  1078
<211>  1245
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1078

Met Arg Ile Val Arg Pro Tyr Gly Arg Ser Phe Val Asp His Asp Pro 
1               5                   10                  15      


Gly Gly Ala Leu Gln Arg Lys Val Glu Leu Arg Ala Pro Val Ser Ala 
            20                  25                  30          


Glu Gly Gly Pro Arg Gln Leu Asp Leu Gly His Phe Ala Leu Thr His 
        35                  40                  45              


Asp Glu Leu Val Ile Ala Gln Trp Val Ser Cys Ile Asp Lys Ile Ala 
    50                  55                  60                  


Thr Lys Pro Arg Glu Gly Arg Glu Pro Ser Gly Asp Gln Arg Glu Phe 
65                  70                  75                  80  


Arg His His Leu Gly Asn Ala Ala Trp Gly His Leu Glu Thr His Gly 
                85                  90                  95      


Leu Leu Ser Gly Leu Arg Asp Pro Gln Lys Arg Ala Arg Leu Ala Lys 
            100                 105                 110         


Leu Trp Gln Met Lys Ile Ala Pro Tyr Asp Phe Ser Ala Arg Thr Arg 
        115                 120                 125             


Arg Ser Arg Gly Pro Gln Gly Val Asp Ala Pro Ala Lys Gly Arg Trp 
    130                 135                 140                 


Phe Gly Val Phe Ala Gly Asp Val Ser Val Gln Glu Ala Asp Cys Gly 
145                 150                 155                 160 


Ala Ile Val Ala Arg Ile His Glu His Leu Tyr Glu Ser Gln Tyr Arg 
                165                 170                 175     


Leu Gly Glu Glu Thr Pro Leu Arg Ser Ala Gly Leu Ile Ala Arg Arg 
            180                 185                 190         


Ala Gly Ala Ile Thr Thr Ser Val Ala Pro Asp Ala Ala Lys Pro Ser 
        195                 200                 205             


Val Ala Thr Trp Ser Glu Ala Asp Leu Ala Arg Tyr Arg Ser Ala Gly 
    210                 215                 220                 


Asp Val Ala Cys Lys Ile Arg Arg Ala Ala Arg Glu Arg Glu Gln Gly 
225                 230                 235                 240 


Arg Asp Gly Ala Gly Thr Arg Arg Val Thr Asn Ser Val Ala Gly Lys 
                245                 250                 255     


Val Leu Phe Asp His Trp Arg Ala Leu Phe Ser Asp Glu Gly Gly Thr 
            260                 265                 270         


Val Arg Ser Phe Arg Asp Val Glu Gly His Asp Pro Gly Leu Ala Ala 
        275                 280                 285             


Leu His Asn Ala Val Arg Glu Cys Tyr Ala Arg Ile Leu Lys Arg His 
    290                 295                 300                 


Lys Lys Lys Pro Pro Gly Arg Asp Ala Gly Pro Glu Ser Ser Ala Ile 
305                 310                 315                 320 


Leu Arg Ala Leu Pro Arg Asp Met Asp Ala Leu Leu Thr Arg Ile Asp 
                325                 330                 335     


Ser Gly Arg Arg Asn Arg Asp Leu Ala Ala Lys Val Arg Leu Gly Lys 
            340                 345                 350         


Leu Ile His Tyr Thr Ala Ser Asp Pro Ala His Asp Arg Ala Gly Ala 
        355                 360                 365             


Val Ala Glu Arg Trp Pro Gly Asp Val Ala Asp Ser Arg Tyr Arg Thr 
    370                 375                 380                 


Ser Ala Gly Gln Ala Glu Ile Lys Arg Asn Glu Ala Phe Val Arg Val 
385                 390                 395                 400 


Trp Arg His Val Leu Val Leu Ala Ala Arg Thr Leu Glu Asn Trp Ala 
                405                 410                 415     


Asp Pro Glu Asn Arg Ile Asn Arg Asp Ile Leu Ser Ser Gly Gly Ala 
            420                 425                 430         


Lys Ala Ala Cys Glu Gln Phe Glu Ser Ser Arg Phe Met His Lys Cys 
        435                 440                 445             


Asn Val Leu Phe Gly Glu Arg Ala Gly His Phe Ile Gly Gln Asp Asp 
    450                 455                 460                 


Ala Ala Leu Gln Lys Ala Val Leu Glu Leu Ala Leu Glu Arg Leu Gly 
465                 470                 475                 480 


Gln Leu Arg Asn Arg Ser Phe His Phe Thr Gly Arg Gly Gly Phe Leu 
                485                 490                 495     


Glu Val Leu Gln Gln Leu Gly Gln Pro Ala Glu Lys Ala Pro Cys Gln 
            500                 505                 510         


Ser Ala His Asp Arg Thr Met Ala Ser Leu Arg Ala Leu Trp Arg Asp 
        515                 520                 525             


Asp Asp Glu Gly Arg Gly Gly Arg Leu Lys Ala Thr Met Thr Gly Ala 
    530                 535                 540                 


His Phe Glu Thr Phe Leu Asp Glu Ala Gln Ile Arg Arg Phe Phe Asp 
545                 550                 555                 560 


Gln Val Ser Thr Gly Gln Glu Ala Glu Pro Pro Leu Pro Arg Phe Gly 
                565                 570                 575     


Arg Val Leu Gln Arg Ala Lys Asn Thr Arg Asp Ala Gln Ser Asp Leu 
            580                 585                 590         


Arg Pro His Leu Pro Asp Pro Gly Asn Met Arg Thr Leu Glu Asp Pro 
        595                 600                 605             


Ala Arg Leu Cys Gln Tyr Thr Ala Leu Lys Leu Leu Tyr Ala Lys Pro 
    610                 615                 620                 


Phe Arg Thr Trp Leu Ala Glu Ala Asp Ser Ala Val Ile Asn Pro Phe 
625                 630                 635                 640 


Ile Glu Ala Ala Val Thr Arg Ala Arg Arg Glu Ala Gln Lys Ile Trp 
                645                 650                 655     


Ala Ala Arg Thr Gly His His Gly Val Asp Glu Glu Ala Lys Ala Leu 
            660                 665                 670         


Ile Gln Pro Arg Met Ala Met Ile Gly Arg Leu Ala Pro Gly Glu Asn 
        675                 680                 685             


Ile Gln Thr Leu Phe Phe Arg Met Ser Ala Glu Thr Ala Thr Glu Met 
    690                 695                 700                 


Arg Val Gln Ala Gly Tyr Glu Ser Asp Pro Asp Ala Ala Arg Glu Gln 
705                 710                 715                 720 


Ala Glu Phe Ile Glu Asn Leu Lys Cys Asp Val Ile Ala Gln Ala Phe 
                725                 730                 735     


Met Arg Phe Leu Asp Glu Ala Gly Phe Asp Phe Leu Leu Thr Leu Asp 
            740                 745                 750         


Ala Arg Ala Ala Arg Pro Glu Ser Ala Arg Phe Asp Leu Ala Met Leu 
        755                 760                 765             


Asp Ala Ala Ala Arg Ala Glu Glu Pro Gln Asp Trp Met Leu Val Leu 
    770                 775                 780                 


Tyr Phe Leu Leu His Leu Val Pro Val Asp Glu Ala Gly Arg Leu Leu 
785                 790                 795                 800 


His Gln Leu Arg Lys Trp Glu Ile Leu Ala Gly Pro Glu Glu Ala Gly 
                805                 810                 815     


Ala Arg Thr Gly Ala Asp Ala Ala Asn Ser Thr Leu Ser Gly Leu Tyr 
            820                 825                 830         


Gln Val Leu Asp Leu Tyr Leu Asp Met His Asp Ala Lys Phe Ser Gly 
        835                 840                 845             


Gly Ala Ala Leu Tyr Gly Ala Arg His Phe Arg Asn Leu Phe Glu Asp 
    850                 855                 860                 


Glu Ala Asp Phe Asp Arg Leu Phe Pro Val Ala Asp Ala Gly Glu Glu 
865                 870                 875                 880 


Asp Lys Arg Ile Pro Leu Arg Gly Leu Arg Glu Ile Leu Arg Phe Gly 
                885                 890                 895     


Asp Arg Ala Thr Leu Glu Ala Ile Tyr Ala Gln Asn Arg Ile Arg Pro 
            900                 905                 910         


Ala Glu Val Ala Glu Val Leu Asp Leu Glu Ala Pro Asp Ala Asp Gly 
        915                 920                 925             


Met Ser Arg Ile Ala Gly His His Ala Arg Arg Glu Lys Leu His Ala 
    930                 935                 940                 


Gln Trp Val Glu Ala Lys Gln Ser Phe Asp Asp Asp Ala Val Arg Asp 
945                 950                 955                 960 


Tyr Phe Val Ala Leu Gly Gln Val Val Arg His Arg His Leu Ala Ala 
                965                 970                 975     


Arg Ala Arg Leu Val Asp His Val Arg Leu His Arg Leu Met Met Asn 
            980                 985                 990         


Val Leu Gly Arg Leu Ala Asp Phe  Ala Gly Leu Trp Glu  Arg Asp Val 
        995                 1000                 1005             


Tyr Phe  Val Met Leu Ala Thr  Leu Tyr Glu Gln Gly  Thr Ser Pro 
    1010                 1015                 1020             


Ala Ala  Val Leu Asn Cys Glu  Ala Arg Arg Lys Leu  Ser Gln Gly 
    1025                 1030                 1035             


Arg Ile  Val Glu Val Ile Arg  Ala Leu Lys Pro Val  Asp Gly Gly 
    1040                 1045                 1050             


Ala Leu  Tyr Ala Ala Ile Thr  Gly His Phe Pro Gly  Phe Asp Thr 
    1055                 1060                 1065             


Arg Arg  Asn Asp Asp Pro Val  Gln Leu Arg Asn Asn  Phe Ala His 
    1070                 1075                 1080             


Phe Asn  Met Leu Arg Gln Gly  His Met Pro Asp Leu  Thr Ala Cys 
    1085                 1090                 1095             


Val Asn  Arg Ala Arg Arg Leu  Met Ala Tyr Asp Arg  Lys Leu Lys 
    1100                 1105                 1110             


Asn Ala  Val Ser Lys Ala Val  Ile Glu Leu Leu Ala  Arg Glu Gly 
    1115                 1120                 1125             


Leu Thr  Leu Ser Trp Arg Met  Asp Ala Arg Gly Pro  Gln His Asp 
    1130                 1135                 1140             


Leu Thr  Glu Ala Arg Ile Thr  Ala Arg Thr Ala Thr  His Leu Gly 
    1145                 1150                 1155             


Gly Ile  Arg Leu Thr Gln Arg  Gly Gly Ser Thr Gly  Ser Arg Pro 
    1160                 1165                 1170             


Phe Pro  Leu Thr Glu Ala Leu  His Gly Thr Gly Phe  Ala Arg Met 
    1175                 1180                 1185             


Val Ala  Gln Leu Phe Ala Gly  Gln Asp Arg Pro Ser  Arg Cys Val 
    1190                 1195                 1200             


Ser Gln  Asp Asp Pro Thr Thr  Ile Glu Arg Ala Pro  Ala Arg Asn 
    1205                 1210                 1215             


Thr Asn  Arg Lys Glu Ser Ala  Lys Lys Arg Met Lys  Pro Gly Arg 
    1220                 1225                 1230             


Asp Gly  Gly Arg Arg His Glu  Lys Ser Arg Arg Gly  
    1235                 1240                 1245 


<210>  1079
<211>  1245
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1079

Met Arg Ile Val Arg Pro Tyr Gly Arg Ser Phe Val Asp His Asp Pro 
1               5                   10                  15      


Gly Gly Ala Leu Gln Arg Lys Val Glu Leu Arg Ala Pro Val Ser Ala 
            20                  25                  30          


Glu Gly Gly Pro Arg Gln Leu Asp Leu Gly His Phe Ala Leu Thr His 
        35                  40                  45              


Asp Glu Leu Val Ile Ala Gln Trp Val Ser Cys Ile Asp Lys Ile Ala 
    50                  55                  60                  


Thr Lys Pro Arg Glu Gly Arg Glu Pro Ser Gly Asp Gln Arg Glu Phe 
65                  70                  75                  80  


Arg His His Leu Gly Asn Ala Ala Trp Gly His Leu Glu Thr His Gly 
                85                  90                  95      


Leu Leu Ser Gly Leu Arg Asp Pro Gln Lys Arg Ala Arg Leu Ala Lys 
            100                 105                 110         


Leu Trp Gln Met Lys Ile Ala Pro Tyr Asp Phe Ser Ala Arg Thr Arg 
        115                 120                 125             


Arg Ser Arg Gly Pro Gln Gly Val Asp Ala Pro Ala Lys Gly Arg Trp 
    130                 135                 140                 


Phe Gly Val Phe Ala Gly Asp Val Ser Val Gln Glu Ala Asp Cys Gly 
145                 150                 155                 160 


Ala Ile Val Ala Arg Ile His Glu His Leu Tyr Glu Ser Gln Tyr Arg 
                165                 170                 175     


Leu Gly Glu Glu Thr Pro Leu Arg Ser Ala Gly Leu Ile Ala Arg Arg 
            180                 185                 190         


Ala Gly Ala Ile Thr Thr Ser Val Ala Pro Asp Ala Ala Lys Pro Ser 
        195                 200                 205             


Val Ala Thr Trp Ser Glu Ala Asp Leu Ala Arg Tyr Arg Ser Ala Gly 
    210                 215                 220                 


Asp Val Ala Cys Lys Ile Arg Arg Ala Ala Arg Glu Arg Glu Gln Gly 
225                 230                 235                 240 


Arg Asp Gly Ala Gly Thr Arg Arg Val Thr Asn Ser Val Ala Gly Lys 
                245                 250                 255     


Val Leu Phe Asp His Trp Arg Ala Leu Phe Ser Asp Glu Gly Gly Thr 
            260                 265                 270         


Val Arg Ser Phe Arg Asp Val Glu Gly His Asp Pro Gly Leu Ala Ala 
        275                 280                 285             


Leu His Asn Ala Val Arg Glu Cys Tyr Ala Arg Ile Leu Lys Arg His 
    290                 295                 300                 


Lys Lys Lys Pro Pro Gly Arg Asp Ala Gly Pro Glu Ser Ser Ala Ile 
305                 310                 315                 320 


Leu Arg Ala Leu Pro Arg Asp Met Asp Ala Leu Leu Thr Arg Ile Asp 
                325                 330                 335     


Ser Gly Arg Arg Asn Arg Asp Leu Ala Ala Lys Val Arg Leu Gly Lys 
            340                 345                 350         


Leu Ile His Tyr Thr Ala Ser Asp Pro Ala His Asp Arg Ala Gly Ala 
        355                 360                 365             


Val Ala Glu Arg Trp Pro Gly Asp Val Ala Asp Ser Arg Tyr Arg Thr 
    370                 375                 380                 


Ser Ala Gly Gln Ala Glu Ile Lys Arg Asn Glu Ala Phe Val Arg Val 
385                 390                 395                 400 


Trp Arg His Val Leu Val Leu Ala Ala Arg Thr Leu Glu Asn Trp Ala 
                405                 410                 415     


Asp Pro Glu Asn Arg Ile Asn Arg Asp Ile Leu Ser Ser Gly Gly Ala 
            420                 425                 430         


Lys Ala Ala Cys Glu Gln Phe Glu Ser Ser Arg Phe Met His Lys Cys 
        435                 440                 445             


Asn Val Leu Phe Gly Glu Arg Ala Gly His Phe Ile Gly Gln Asp Asp 
    450                 455                 460                 


Ala Ala Leu Gln Lys Ala Val Leu Glu Leu Ala Leu Glu Arg Leu Gly 
465                 470                 475                 480 


Gln Leu Arg Asn Arg Ser Phe His Phe Thr Gly Arg Gly Gly Phe Leu 
                485                 490                 495     


Glu Val Leu Gln Gln Leu Gly Gln Pro Ala Glu Lys Ala Pro Cys Gln 
            500                 505                 510         


Ser Ala His Asp Arg Thr Met Ala Ser Leu Arg Ala Leu Trp Arg Asp 
        515                 520                 525             


Asp Asp Glu Gly Arg Gly Gly Arg Leu Lys Ala Thr Met Thr Gly Ala 
    530                 535                 540                 


His Phe Glu Thr Phe Leu Asp Glu Ala Gln Ile Arg Arg Phe Phe Asp 
545                 550                 555                 560 


Gln Val Ser Thr Gly Gln Glu Ala Glu Pro Pro Leu Pro Arg Phe Gly 
                565                 570                 575     


Arg Val Leu Gln Arg Ala Lys Asn Thr Arg Asp Ala Gln Ser Asp Leu 
            580                 585                 590         


Arg Pro His Leu Pro Asp Pro Gly Asn Met Arg Thr Leu Glu Asp Pro 
        595                 600                 605             


Ala Arg Leu Cys Gln Tyr Thr Ala Leu Lys Leu Leu Tyr Ala Lys Pro 
    610                 615                 620                 


Phe Arg Thr Trp Leu Ala Glu Ala Asp Ser Ala Val Ile Asn Pro Phe 
625                 630                 635                 640 


Ile Glu Ala Ala Val Thr Arg Ala Arg Arg Glu Ala Gln Lys Ile Trp 
                645                 650                 655     


Ala Ala Arg Thr Gly His His Gly Val Asp Glu Glu Ala Lys Ala Leu 
            660                 665                 670         


Ile Gln Pro Arg Met Ala Met Ile Gly Arg Leu Ala Pro Gly Glu Asn 
        675                 680                 685             


Ile Gln Thr Leu Phe Phe Arg Met Ser Ala Glu Thr Ala Thr Glu Met 
    690                 695                 700                 


Arg Val Gln Ala Gly Tyr Glu Ser Asp Pro Asp Ala Ala Arg Glu Gln 
705                 710                 715                 720 


Ala Glu Phe Ile Glu Asn Leu Lys Cys Asp Val Ile Ala Gln Ala Phe 
                725                 730                 735     


Met Arg Phe Leu Asp Glu Ala Gly Phe Asp Phe Leu Leu Thr Leu Asp 
            740                 745                 750         


Ala Arg Ala Ala Arg Pro Glu Ser Ala Arg Phe Asp Leu Ala Met Leu 
        755                 760                 765             


Asp Ala Ala Ala Arg Ala Glu Glu Pro Gln Asp Trp Met Leu Val Leu 
    770                 775                 780                 


Tyr Phe Leu Leu His Leu Val Pro Val Asp Glu Ala Gly Arg Leu Leu 
785                 790                 795                 800 


His Gln Leu Arg Lys Trp Glu Ile Leu Ala Gly Pro Glu Glu Ala Gly 
                805                 810                 815     


Ala Arg Thr Gly Ala Asp Ala Ala Asn Ser Thr Leu Ser Gly Leu Tyr 
            820                 825                 830         


Gln Val Leu Asp Leu Tyr Leu Asp Met His Asp Ala Lys Phe Ser Gly 
        835                 840                 845             


Gly Ala Ala Leu Tyr Gly Ala Arg His Phe Arg Asn Leu Phe Glu Asp 
    850                 855                 860                 


Glu Ala Asp Phe Asp Arg Leu Phe Pro Val Ala Asp Ala Gly Glu Glu 
865                 870                 875                 880 


Asp Lys Arg Ile Pro Leu Arg Gly Leu Arg Glu Ile Leu Arg Phe Gly 
                885                 890                 895     


Asp Arg Ala Thr Leu Glu Ala Ile Tyr Ala Gln Asn Arg Ile Arg Pro 
            900                 905                 910         


Ala Glu Val Ala Glu Val Leu Asp Leu Glu Ala Pro Asp Ala Asp Gly 
        915                 920                 925             


Met Ser Arg Ile Ala Gly His His Ala Arg Arg Glu Lys Leu His Ala 
    930                 935                 940                 


Gln Trp Val Glu Ala Lys Gln Ser Phe Asp Asp Asp Ala Val Arg Asp 
945                 950                 955                 960 


Tyr Phe Val Ala Leu Gly Gln Val Val Arg His Arg His Leu Ala Ala 
                965                 970                 975     


Arg Ala Arg Leu Val Asp His Val Arg Leu His Arg Leu Met Met Asn 
            980                 985                 990         


Val Leu Gly Arg Leu Ala Asp Phe  Ala Gly Leu Trp Glu  Arg Asp Val 
        995                 1000                 1005             


Tyr Phe  Val Met Leu Ala Thr  Leu Tyr Glu Gln Gly  Thr Ser Pro 
    1010                 1015                 1020             


Ala Ala  Val Leu Asn Cys Glu  Ala Arg Arg Lys Leu  Ser Gln Gly 
    1025                 1030                 1035             


Arg Ile  Val Glu Val Ile Arg  Ala Leu Lys Pro Val  Asp Gly Gly 
    1040                 1045                 1050             


Ala Leu  Tyr Ala Ala Ile Thr  Gly His Phe Pro Gly  Phe Asp Thr 
    1055                 1060                 1065             


Arg Arg  Asn Asp Asp Pro Val  Gln Leu Arg Asn Asn  Phe Ala His 
    1070                 1075                 1080             


Phe Asn  Met Leu Arg Gln Gly  His Met Pro Asp Leu  Thr Ala Cys 
    1085                 1090                 1095             


Val Asn  Arg Ala Arg Arg Leu  Met Ala Tyr Asp Arg  Lys Leu Lys 
    1100                 1105                 1110             


Asn Ala  Val Ser Lys Ala Val  Ile Glu Leu Leu Ala  Arg Glu Gly 
    1115                 1120                 1125             


Leu Thr  Leu Ser Trp Arg Met  Asp Ala Arg Gly Pro  Gln His Asp 
    1130                 1135                 1140             


Leu Thr  Glu Ala Arg Ile Thr  Ala Arg Thr Ala Thr  His Leu Gly 
    1145                 1150                 1155             


Gly Ile  Arg Leu Thr Gln Arg  Gly Gly Ser Thr Gly  Ser Arg Pro 
    1160                 1165                 1170             


Phe Pro  Leu Thr Glu Ala Leu  His Gly Thr Gly Phe  Ala Arg Met 
    1175                 1180                 1185             


Val Ala  Gln Leu Phe Ala Gly  Gln Asp Arg Pro Ser  Arg Cys Val 
    1190                 1195                 1200             


Ser Gln  Asp Asp Pro Thr Thr  Ile Glu Arg Ala Pro  Ala Arg Asn 
    1205                 1210                 1215             


Thr Asn  Arg Lys Glu Ser Ala  Lys Lys Arg Met Lys  Pro Gly Arg 
    1220                 1225                 1230             


Asp Gly  Gly Arg Arg His Glu  Lys Ser Arg Arg Gly  
    1235                 1240                 1245 


<210>  1080
<211>  1287
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1080

Met Arg Ile Gly Lys Val Gln Gly Arg Thr Phe Thr Gly Phe Asp Asn 
1               5                   10                  15      


Ala Arg Gly Lys Thr Leu Arg Arg Arg Leu Leu Thr Arg Pro Asp Asn 
            20                  25                  30          


Glu Ala Arg Ser Leu Ser Glu His Leu Ala His Asp Pro Lys Ala Leu 
        35                  40                  45              


Ile Gly Gln Ala Ile Ser Arg Ile Asp Thr Ile Tyr Gln Lys Pro Lys 
    50                  55                  60                  


Thr Gly Lys Pro Thr Pro Glu Gln Phe Gly His Arg Asp Thr Leu Gly 
65                  70                  75                  80  


Trp Ala Tyr Trp Lys Leu Leu Val Ala Ser Tyr Pro Glu Val Glu Gly 
                85                  90                  95      


His Arg Asp Leu Phe Val Arg Arg Leu His Pro Tyr Gly Asp Thr Pro 
            100                 105                 110         


Pro Lys Ser His Gly Gln Lys Glu Gly Glu His Gln Lys Gly Gly Lys 
        115                 120                 125             


Pro Gln Leu Glu Gly Arg Trp His Gly Val Met Ala Gln His Gly Lys 
    130                 135                 140                 


Asn Pro Asp Gln Ile Ala Ala Arg Leu Phe Asp His Leu His Asn Ser 
145                 150                 155                 160 


Glu Leu Arg Phe Gly Gly Thr Ala Ser Gly Glu Pro Arg Thr Arg Pro 
                165                 170                 175     


Gly Lys Glu Ala Thr Pro Thr Gly Leu Ile Gly Ala Arg Ala Lys Thr 
            180                 185                 190         


Ile Glu His Ser Val Leu Pro Arg Asp Ala Lys Arg Phe Val Ala Glu 
        195                 200                 205             


Trp Arg Gly Glu Asp Gln Glu Arg Tyr Ala Gly Ala Arg Asp Ile Ala 
    210                 215                 220                 


Ala Ala Ile Ser Ala Gly Leu Asn Asp Lys Asp Gln Lys Ser Gly Ser 
225                 230                 235                 240 


Gly Arg Lys Ser Ala Val Ile Gly Lys Leu Leu Ser Asp His Leu Glu 
                245                 250                 255     


Thr Leu Thr Gly Asn Arg Lys Cys Arg Phe Asp Pro Lys Ser Thr Ala 
            260                 265                 270         


Glu Thr Leu Glu Leu Arg Asp Gly Glu Ser Val Asp Asp Arg Arg Arg 
        275                 280                 285             


Ile Leu Glu Leu His Ala Glu Val Lys Ala Thr Tyr Lys Arg Met Ala 
    290                 295                 300                 


Ala Trp Lys Pro Ala Lys Leu Pro Arg Asn Ser Asp Glu Leu Phe Arg 
305                 310                 315                 320 


Leu Val Arg Gln Gln Ala Asp Asn Arg Ile Leu Asn His Leu Val Arg 
                325                 330                 335     


Val Gly Arg Ile Ser Val Tyr Ser Glu Gln Ser Asp Ala Leu Ser Glu 
            340                 345                 350         


Ser Gln Phe Trp Thr Ser Gly Gly Gln Thr Gln Ile Lys Glu Ser Glu 
        355                 360                 365             


Val Phe Ala Arg Leu Trp Ile Gly Ala Ile Ser Arg Ala Ser Tyr Ser 
    370                 375                 380                 


Met Lys Ala Trp Leu Glu Pro Glu Gly Thr Val Phe Asn Pro Ser Ile 
385                 390                 395                 400 


Asn Asp Phe Asp Val Thr Ser Ser His Asn Thr Asn Arg Ile Leu Glu 
                405                 410                 415     


Asp Ser Gly Arg Leu Ser Asn Ala Met Ala Arg Arg Ala Ile Tyr Phe 
            420                 425                 430         


Gly Glu Thr Pro Glu Phe Asp Ala Leu Gly Glu Glu Asp Gln Arg Val 
        435                 440                 445             


Leu Val Lys Lys Cys Leu Asp Ala Leu Ser Ala Cys Arg Asn Arg Thr 
    450                 455                 460                 


Phe His His Gly Gln Arg Ala Lys Phe Leu Lys Glu Val Arg Lys Gly 
465                 470                 475                 480 


Leu Lys Glu Lys Glu Ala Asp Ser Ala Gly Pro Ala Ala Trp Glu Gly 
                485                 490                 495     


Ile Arg Glu Val Ile Gln Ala Asp Ala Arg Asn Leu Gly Ala Arg Leu 
            500                 505                 510         


Leu Gln Asp Leu Thr Gly Ala Lys Val His Ser Phe Ala Thr Asp Pro 
        515                 520                 525             


Glu Phe Arg His Leu Tyr Glu Ser Val Ala Ala Thr Leu Thr Ala Gly 
    530                 535                 540                 


Gly Glu Leu Glu Ala Ala Leu Pro Arg Leu Lys Asn Val Leu Lys Arg 
545                 550                 555                 560 


Ala Glu Gly Val Arg Cys Tyr Leu Asp Thr Pro Ser Gln Arg Arg Glu 
                565                 570                 575     


Gly Asp Glu Ser Leu Ile Ala Arg Leu Pro Val Ala Pro Val Pro Arg 
            580                 585                 590         


Glu Leu Asp Asp Ala Ala Thr Lys Ala Arg His Ser Ala Leu Leu Arg 
        595                 600                 605             


Leu Tyr Asp Gly Pro Phe Arg Pro Trp Ala Thr Glu Leu Arg Gly Glu 
    610                 615                 620                 


Arg Leu Ser Asp Tyr Ala Ala Arg Ala Lys Arg Leu Ala Thr Arg Leu 
625                 630                 635                 640 


Ala Lys Ser Thr Asn Thr Ala Ser Pro Tyr Pro Asp Ser Val Glu Gly 
                645                 650                 655     


Arg Ser Val Arg Leu Arg Asp Pro Ile Thr Ala Asp Thr Ala Pro Glu 
            660                 665                 670         


Thr Leu Lys Thr Tyr Leu Ser Ala Leu Thr Ala Glu Thr Ala Thr Glu 
        675                 680                 685             


Phe Arg Val Gln Lys Gly Tyr Glu Ser Asp Gly Glu Lys Ala Lys Glu 
    690                 695                 700                 


Gln Ala Glu Phe Ile Glu Asp Phe Arg Arg Asp Met Ile Ala Leu Ala 
705                 710                 715                 720 


Phe Gln Asp Phe Ile Arg Asp His Gly Phe Ala Trp Leu Leu Asp Ile 
                725                 730                 735     


Ala Ser Lys Ala Glu Pro Ser Asn Asp Ala Pro Asn Leu Pro Asp Pro 
            740                 745                 750         


Val Asp Thr Gly Lys Asp Thr Val Phe Glu Asp Trp Gln Ala Leu Leu 
        755                 760                 765             


Tyr Leu Phe Leu His Phe Val Pro Ala Asp Asp Val Ser Gln Leu Leu 
    770                 775                 780                 


His Gln Leu Arg Lys Trp Asp Ala Leu Gln Asp Lys Tyr Glu Leu Ala 
785                 790                 795                 800 


Glu Pro Gly Glu Thr Leu Gly Gln Thr Lys Ala Asp Thr Arg Lys Ile 
                805                 810                 815     


Val Gly Gln Phe Arg Asp Cys Leu Thr Leu Phe Leu Lys Thr Gly Asp 
            820                 825                 830         


Ala Arg Phe Asp Gly Glu Gly Val Glu Leu Pro Leu Ser Asp Phe Gln 
        835                 840                 845             


Glu Leu Phe Glu Ser Pro Ala Thr Phe Lys Glu Leu Phe Leu Ala Glu 
    850                 855                 860                 


Pro Ala Glu Asn Asp Ala Ser Glu Thr Asp Asp Gln Asp Ala Pro Gly 
865                 870                 875                 880 


Glu Lys His Arg Val Thr Arg Thr Arg Arg Gly Leu Arg Gln Ile Leu 
                885                 890                 895     


Arg Tyr Asn His Met Pro Val Leu Arg Asp Leu Phe Leu Ala His Lys 
            900                 905                 910         


Val Thr Asp Ala Glu Val Asp Gly Leu Gln Ala Leu Glu Val Asp Asp 
        915                 920                 925             


Pro Gln Thr Gly Glu Ser Gln Ile Gly Ala Ala Gln Arg Ile Arg Thr 
    930                 935                 940                 


Glu Ile His His His Thr Ser Asn Asp Lys Gln Ile Ser Glu Ala Lys 
945                 950                 955                 960 


Val Glu Glu Tyr Arg Arg Ala Leu Ser Thr Ile Glu Arg His Arg Phe 
                965                 970                 975     


Leu Val Gly Arg Val Tyr Leu Gly Asp His Ile Arg Val His Lys Leu 
            980                 985                 990         


Met Met Asp Val Met Gly Arg Leu  Val Asp Phe Ala Gly  Ala Trp Glu 
        995                 1000                 1005             


Arg Glu  Ala Ala Asp Gly Asp  Arg Lys Gly Phe Ile  Ser Arg Ala 
    1010                 1015                 1020             


Ile Ala  Leu Pro Glu Val Ala  Glu Gly Tyr Ala Ala  Asp Arg Leu 
    1025                 1030                 1035             


Lys Thr  Val Ala Arg Arg Val  Leu Asp Asp Gly Glu  Ala Arg Arg 
    1040                 1045                 1050             


Ile Arg  Asn Asp Leu Gly His  Phe Asn Asp Leu Ala  Pro Thr Ser 
    1055                 1060                 1065             


Gly Pro  Ala Asn Leu Thr Phe  Val Val Asn Arg Ala  Arg Arg Met 
    1070                 1075                 1080             


Met Arg  His Asp Arg Lys Arg  Lys Asn Ala Val Thr  Lys Ser Val 
    1085                 1090                 1095             


Ile Glu  Ile Leu Asn Arg Gln  Gly Leu Gly Ile Glu  Trp Thr Met 
    1100                 1105                 1110             


Arg Asn  His Glu Leu Cys Glu  Ala Lys Leu Trp Gln  Asn Pro Val 
    1115                 1120                 1125             


Lys His  Leu Gly Phe Ala Thr  Leu Glu Gly Arg Gly  Lys Lys Trp 
    1130                 1135                 1140             


Arg Arg  Pro Phe Glu Ala Arg  Tyr Gly Asp Ala Tyr  Met Ala Met 
    1145                 1150                 1155             


Val Ala  Gln Leu Phe Asp Gly  Thr Val Thr Ser Pro  Pro Ala Lys 
    1160                 1165                 1170             


Gly Pro  Pro Gln Ser Gly Lys  Ser Gly Gly Lys Pro  Gly Lys Gly 
    1175                 1180                 1185             


Ala Glu  Gly Gly Ala Lys Glu  Lys Ser Arg Ser Pro  Thr Arg Met 
    1190                 1195                 1200             


Glu Glu  Gly Gly Val Tyr Glu  Gly Arg Val Ala Lys  Ala Lys Ser 
    1205                 1210                 1215             


Asp Lys  Gly Phe Gly Phe Leu  Leu Val Glu Gly Ala  Gln Glu Glu 
    1220                 1225                 1230             


Ile Phe  Leu His Ile Tyr Gly  Ile Ser Gly Asn Arg  Pro Ala Arg 
    1235                 1240                 1245             


Ile Glu  Asn Gly Gln Arg Tyr  Arg Phe Thr Leu Gly  Ile Asp Arg 
    1250                 1255                 1260             


Asp Arg  Glu Arg Arg Lys Glu  Arg Ala Trp Val Ala  Arg Glu Ala 
    1265                 1270                 1275             


Val Arg  Ile Asp Glu Asn Arg  Ser Lys 
    1280                 1285         


<210>  1081
<211>  1169
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1081

Met Gly Ser Gly Lys Tyr Arg Ile Thr Lys Ile Ala Arg Asp Trp Asp 
1               5                   10                  15      


Glu Asn Lys Lys Arg Ile Ile Leu Lys Arg Ile Val Ser Asp Gly Glu 
            20                  25                  30          


Val Lys Tyr Val Asn Glu Asn Asn Asn Val Asp Ile Asp Ile Thr Glu 
        35                  40                  45              


Thr Tyr Tyr Arg Ile Leu Ser Asn Asn Lys Ala Lys Phe Leu Gly Ser 
    50                  55                  60                  


Asn Glu Gln Phe Ile Phe Lys Val Asn Lys Met Lys Arg Asn Ile Lys 
65                  70                  75                  80  


Asn Asp Cys Val Ile Ile Lys Asp Tyr Thr Glu Glu Glu Phe Glu Lys 
                85                  90                  95      


Leu Asp Lys Lys Ile Phe Phe Ser Arg Lys Ile Lys Val Asn Asn Lys 
            100                 105                 110         


Asp Arg Glu Lys Ile Cys Arg Asn Phe Tyr Glu Asp Glu Arg Glu Ile 
        115                 120                 125             


Met Lys Lys Arg Leu Glu Glu Ala Lys Lys Phe Asn Asn Ile Ile Phe 
    130                 135                 140                 


Asn Ile Cys Asn Lys Ile Phe Lys Leu Glu Tyr Leu Asp Tyr Thr Asp 
145                 150                 155                 160 


Glu Lys Val Tyr Lys Ile Phe Gln Asn Glu Ile Lys Val Lys Asp Val 
                165                 170                 175     


Lys Asn Leu Lys Glu Ala Phe Lys Gln Gln Glu Lys Gly Leu Glu Thr 
            180                 185                 190         


Asp Lys Leu Leu Ala Ile Ser Phe Asn Lys Lys Arg Asn Asn Ile Leu 
        195                 200                 205             


Leu Glu Phe Ile Gln Gln Ile Ala Lys Gln Glu Phe Glu Asn Gln Lys 
    210                 215                 220                 


Glu Leu Glu Asn Trp Phe Ser Tyr Gly Gly Glu Lys Tyr Cys Lys Glu 
225                 230                 235                 240 


Ile Phe Lys Ile Tyr Ser Asn Met Ser Gln Lys Glu Lys Tyr Phe Lys 
                245                 250                 255     


Leu Leu Gly His Arg Asn Gln Gly Ile Ala Ser Ile Tyr Asp Glu Lys 
            260                 265                 270         


Lys Glu Thr Leu Gln Arg Arg Leu Lys Leu Gly Asp Tyr Ser Lys Tyr 
        275                 280                 285             


Asp Leu Lys Arg Tyr Tyr Gln Lys Asp Tyr Lys Glu Glu Ala Ile Lys 
    290                 295                 300                 


Glu Leu Lys Asp Lys Asn Lys Glu Gly Leu Glu Arg Glu Ile Glu Glu 
305                 310                 315                 320 


Leu Ile Lys Lys Asn Tyr Lys Ile Asp Lys Leu Cys Asp Glu Ile Ser 
                325                 330                 335     


Asn Leu Glu Phe Ser Phe Val Glu Ser Lys Lys Glu Asn Lys Asp Lys 
            340                 345                 350         


Met Ser Glu Ile Ile Val Lys Ile Lys Glu His Tyr Lys Lys Asn Val 
        355                 360                 365             


Asn Val Glu Glu Glu Leu Glu Asn Lys Glu Lys Tyr Ile Leu Ser Ile 
    370                 375                 380                 


Ile His Asn Tyr Val Lys Gly Arg Tyr Arg Lys Cys Leu Glu Leu Gln 
385                 390                 395                 400 


Gln Lys Glu Asn Val Asp Phe Glu Asn Leu Glu Lys Arg Ile Lys Glu 
                405                 410                 415     


Ile Phe Asp Ser Asn Glu Val Thr Lys Lys Leu Lys Lys Ser Ile Ile 
            420                 425                 430         


Asn Lys Val Asn Ser Tyr Lys Ile Phe Glu Met Lys Phe Gln Asn Pro 
        435                 440                 445             


Asn Val Glu Ser Ser Asp Asp Leu Glu Ile Leu Lys Ala Glu Glu Thr 
    450                 455                 460                 


Phe Leu Asn Lys Leu Ser Thr Ala Val Ser Lys Val Gly Tyr Ile Leu 
465                 470                 475                 480 


Asn Ile Leu Leu Glu Ile His Phe Arg Asn Asp Ile Leu Gln Asp Tyr 
                485                 490                 495     


Asn Gln Val Glu Lys Leu Trp Lys Ser Asp Ser Phe Gln Lys Ile Cys 
            500                 505                 510         


Ala Ile Tyr Pro Glu Ile Asn Asn Asp Glu Lys Leu Leu Lys Gly Met 
        515                 520                 525             


Ile Tyr Phe Ile Gln Gly Leu Arg Gln Gln Val Leu His Pro Lys Ile 
    530                 535                 540                 


Leu Trp Glu Lys Gln Asn Ile Tyr Asn Ala Glu Asn Ile Lys Glu Lys 
545                 550                 555                 560 


Glu Lys Ile Val Ser Val Lys Leu Gln Asn Glu Gly Glu Ala Tyr Asn 
                565                 570                 575     


Lys Lys Gly Ile Gln Asn Tyr Phe Glu Asn Val Leu Lys Lys Ile Pro 
            580                 585                 590         


Asp Tyr Phe Ile Glu Lys Tyr Glu Ser Asn Asn Val Phe Asn Ile Tyr 
        595                 600                 605             


Arg Asn Ser Val Asp Lys Ile Met Glu Val Val Lys Asn Phe Asn Phe 
    610                 615                 620                 


Lys Glu Asn Asn Thr Ile Asp Tyr Leu Phe Pro Lys Phe His Lys Ile 
625                 630                 635                 640 


Tyr Lys Arg Met Cys Lys Ser Glu Asn Ile Asp Asp Arg Gln Asn Gly 
                645                 650                 655     


Ala Arg Lys Tyr Leu Leu Gln Thr Ile Tyr Tyr Tyr Tyr Phe Gln Tyr 
            660                 665                 670         


Glu Ile Glu Asn Asp Lys Asn Asn Met Ser Lys Tyr Leu Asn Leu Tyr 
        675                 680                 685             


Arg Asn Lys Ile Lys Val Lys Lys Ile Ser Tyr Ser Tyr Ile Ile Asp 
    690                 695                 700                 


Asn Lys Ala Val Asn Asn Lys Asn Ile Glu Ile Leu Tyr Arg Asn Ile 
705                 710                 715                 720 


Gln Arg Glu Gly Met Leu Asn Asn Arg Leu Leu Gln Met Asn Asn Glu 
                725                 730                 735     


Trp Ile Glu Phe Ile Val Val Gln Phe Ser Glu Phe Leu Thr Lys Lys 
            740                 745                 750         


Lys Leu Asn Trp Ile Leu Asp Asp Leu Ser Glu Tyr Lys Lys Lys Glu 
        755                 760                 765             


Lys Leu Asp Glu Asn Asp Lys Asn Glu Leu Leu Lys Ile Phe Lys Gln 
    770                 775                 780                 


Lys Met Asn Lys Asn Ile Thr Tyr Ser Asn Asp Ser Tyr Ala Phe Ile 
785                 790                 795                 800 


Ser Leu Ala Gln Phe Leu Asp Leu Lys Glu Ile Ser Asn Leu Ile His 
                805                 810                 815     


Asp Ile Lys Lys Phe Val Gln Phe Arg Glu Lys Asn Ile Leu Lys Tyr 
            820                 825                 830         


Asn Pro Glu Lys Asn Lys Ile Tyr Ile Glu Glu Leu Arg Lys Ile Leu 
        835                 840                 845             


Tyr Ile Leu Lys Val Met Leu Glu His Lys Glu Arg Val Ile Gln Lys 
    850                 855                 860                 


His Tyr Leu Gly Ser Tyr Asp Glu Asp Ile Ser Ile Met Tyr Gly Lys 
865                 870                 875                 880 


Asp Ile Glu Lys Lys Asp Ile Lys Asp Ile Glu Ile Lys Ile Lys Asn 
                885                 890                 895     


Lys Asn Gln Glu Val Ile Asn Gln Pro Leu Tyr Lys Ser Gly Asn Asp 
            900                 905                 910         


Glu Asn Ser Ser Trp Ile Ile Leu Tyr Gly Ile Glu Gln Ala Lys Arg 
        915                 920                 925             


Asn Gly Thr Phe Lys Phe Phe Glu Gly Phe Phe Asn Leu Asn Asp Asp 
    930                 935                 940                 


Ile Lys Leu Cys Lys Glu Asp Ile Glu Lys Tyr Glu Lys Leu Tyr Asn 
945                 950                 955                 960 


Glu Lys Glu Glu Asn Gln Lys Lys Val Asp Glu Tyr Ile Ser Lys Leu 
                965                 970                 975     


Asn Asn Asp Ile Glu Lys Ile Asn Asn Asp Ile Asn Ile Glu Lys Thr 
            980                 985                 990         


Asn Asp Asn Lys Gln Leu Phe Tyr  Tyr Tyr Lys Asn Met  Ile Tyr Gly 
        995                 1000                 1005             


Asp Gly  Leu Lys Lys Gly Tyr  Asp Phe Ile Asn Asp  Ile Tyr Ser 
    1010                 1015                 1020             


His Tyr  Leu Ser Trp Ala Tyr  Arg Ile Glu Arg Asp  Cys Lys Ile 
    1025                 1030                 1035             


Tyr Lys  Ile Lys Glu Tyr Glu  Asn Lys Lys Asn Phe  Asn Glu Tyr 
    1040                 1045                 1050             


Lys Phe  Lys Glu Tyr Lys Ser  Ile Lys Tyr Phe Arg  Asn Glu Ile 
    1055                 1060                 1065             


Ala His  Phe Asn Tyr Phe Gln  Lys Thr Asn Lys Ser  Leu Leu Glu 
    1070                 1075                 1080             


Leu Leu  Asn Asn Phe Tyr Asp  Ile Phe Asp Tyr Asn  Leu Lys Tyr 
    1085                 1090                 1095             


Gln Arg  Asp Val Gln Lys Val  Ile Asn Asn Ile Phe  Glu Lys Tyr 
    1100                 1105                 1110             


Gln Val  Ile Arg Glu Asp Gly  Gly Pro Val Ile Phe  Tyr Cys Lys 
    1115                 1120                 1125             


Ile Asp  Lys Lys Leu Lys Leu  Ser Glu Asn Ile Ile  Pro Lys Lys 
    1130                 1135                 1140             


His Leu  Lys Cys Ser Lys Ile  Lys Leu Ile His Glu  Lys Tyr Val 
    1145                 1150                 1155             


Glu Phe  Phe Arg Lys Leu Phe  Glu Tyr Lys Lys 
    1160                 1165                 


<210>  1082
<211>  1169
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1082

Met Gly Ser Gly Lys Tyr Arg Ile Thr Lys Ile Ala Arg Asp Trp Asp 
1               5                   10                  15      


Glu Asn Lys Lys Arg Ile Ile Leu Lys Arg Ile Val Ser Asp Gly Glu 
            20                  25                  30          


Val Lys Tyr Val Asn Glu Asn Asn Asn Val Asp Ile Asp Ile Thr Glu 
        35                  40                  45              


Thr Tyr Tyr Arg Ile Leu Ser Asn Asn Lys Ala Lys Phe Leu Gly Ser 
    50                  55                  60                  


Asn Glu Gln Phe Ile Phe Lys Val Asn Lys Met Lys Arg Asn Ile Lys 
65                  70                  75                  80  


Asn Asp Cys Val Ile Ile Lys Asp Tyr Thr Glu Glu Glu Phe Glu Lys 
                85                  90                  95      


Leu Asp Lys Lys Ile Phe Phe Ser Arg Lys Ile Lys Val Asn Asn Lys 
            100                 105                 110         


Asp Arg Glu Lys Ile Cys Arg Asn Phe Tyr Glu Asp Glu Arg Glu Ile 
        115                 120                 125             


Met Lys Lys Arg Leu Glu Glu Ala Lys Lys Phe Asn Asn Ile Ile Phe 
    130                 135                 140                 


Asn Ile Cys Asn Lys Ile Phe Lys Leu Glu Tyr Leu Asp Tyr Thr Asp 
145                 150                 155                 160 


Glu Lys Val Tyr Lys Ile Phe Gln Asn Glu Ile Lys Val Lys Asp Val 
                165                 170                 175     


Lys Asn Leu Lys Glu Ala Phe Lys Gln Gln Glu Lys Gly Leu Glu Thr 
            180                 185                 190         


Asp Lys Leu Leu Ala Ile Ser Phe Asn Lys Lys Arg Asn Asn Ile Leu 
        195                 200                 205             


Leu Glu Phe Ile Gln Gln Ile Ala Lys Gln Glu Phe Glu Asn Gln Lys 
    210                 215                 220                 


Glu Leu Glu Asn Trp Phe Ser Tyr Gly Gly Glu Lys Tyr Cys Lys Glu 
225                 230                 235                 240 


Ile Phe Lys Ile Tyr Ser Asn Met Ser Gln Lys Glu Lys Tyr Phe Lys 
                245                 250                 255     


Leu Leu Gly His Arg Asn Gln Gly Ile Ala Ser Ile Tyr Asp Glu Lys 
            260                 265                 270         


Lys Glu Thr Leu Gln Arg Arg Leu Lys Leu Gly Asp Tyr Ser Lys Tyr 
        275                 280                 285             


Asp Leu Lys Arg Tyr Tyr Gln Lys Asp Tyr Lys Glu Glu Ala Ile Lys 
    290                 295                 300                 


Glu Leu Lys Asp Lys Asn Lys Glu Gly Leu Glu Arg Glu Ile Glu Glu 
305                 310                 315                 320 


Leu Ile Lys Lys Asn Tyr Lys Ile Asp Lys Leu Cys Asp Glu Ile Ser 
                325                 330                 335     


Asn Leu Glu Phe Ser Phe Val Glu Ser Lys Lys Glu Asn Lys Asp Lys 
            340                 345                 350         


Met Ser Glu Ile Ile Val Lys Ile Lys Glu His Tyr Lys Lys Asn Val 
        355                 360                 365             


Asn Val Glu Glu Glu Leu Glu Asn Lys Glu Lys Tyr Ile Leu Ser Ile 
    370                 375                 380                 


Ile His Asn Tyr Val Lys Gly Arg Tyr Arg Lys Cys Leu Glu Leu Gln 
385                 390                 395                 400 


Gln Lys Glu Asn Val Asp Phe Glu Asn Leu Glu Lys Arg Ile Lys Glu 
                405                 410                 415     


Ile Phe Asp Ser Asn Glu Val Thr Lys Lys Leu Lys Lys Ser Ile Ile 
            420                 425                 430         


Asn Lys Val Asn Ser Tyr Lys Ile Phe Glu Met Lys Phe Gln Asn Pro 
        435                 440                 445             


Asn Val Glu Ser Ser Asp Asp Leu Glu Ile Leu Lys Ala Glu Glu Thr 
    450                 455                 460                 


Phe Leu Asn Lys Leu Ser Thr Ala Val Ser Lys Val Gly Tyr Ile Leu 
465                 470                 475                 480 


Asn Ile Leu Leu Glu Ile His Phe Arg Asn Asp Ile Leu Gln Asp Tyr 
                485                 490                 495     


Asn Gln Val Glu Lys Leu Trp Lys Ser Asp Ser Phe Gln Lys Ile Cys 
            500                 505                 510         


Ala Ile Tyr Pro Glu Ile Asn Asn Asp Glu Lys Leu Leu Lys Gly Met 
        515                 520                 525             


Ile Tyr Phe Ile Gln Gly Leu Arg Gln Gln Val Leu His Pro Lys Ile 
    530                 535                 540                 


Leu Trp Glu Lys Gln Asn Ile Tyr Asn Ala Glu Asn Ile Lys Glu Lys 
545                 550                 555                 560 


Glu Lys Ile Val Ser Val Lys Leu Gln Asn Glu Gly Glu Ala Tyr Asn 
                565                 570                 575     


Lys Lys Gly Ile Gln Asn Tyr Phe Glu Asn Val Leu Lys Lys Ile Pro 
            580                 585                 590         


Asp Tyr Phe Ile Glu Lys Tyr Glu Ser Asn Asn Val Phe Asn Ile Tyr 
        595                 600                 605             


Arg Asn Ser Val Asp Lys Ile Met Glu Val Val Lys Asn Phe Asn Phe 
    610                 615                 620                 


Lys Glu Asn Asn Thr Ile Asp Tyr Leu Phe Pro Lys Phe His Lys Ile 
625                 630                 635                 640 


Tyr Lys Arg Met Cys Lys Ser Glu Asn Ile Asp Asp Arg Gln Asn Gly 
                645                 650                 655     


Ala Arg Lys Tyr Leu Leu Gln Thr Ile Tyr Tyr Tyr Tyr Phe Gln Tyr 
            660                 665                 670         


Glu Ile Glu Asn Asp Lys Asn Asn Met Ser Lys Tyr Leu Asn Leu Tyr 
        675                 680                 685             


Arg Asn Lys Ile Lys Val Lys Lys Ile Ser Tyr Ser Tyr Ile Ile Asp 
    690                 695                 700                 


Asn Lys Ala Val Asn Asn Lys Asn Ile Glu Ile Leu Tyr Arg Asn Ile 
705                 710                 715                 720 


Gln Arg Glu Gly Met Leu Asn Asn Arg Leu Leu Gln Met Asn Asn Glu 
                725                 730                 735     


Trp Ile Glu Phe Ile Val Val Gln Phe Ser Glu Phe Leu Thr Lys Lys 
            740                 745                 750         


Lys Leu Asn Trp Ile Leu Asp Asp Leu Ser Glu Tyr Lys Lys Lys Glu 
        755                 760                 765             


Lys Leu Asp Glu Asn Asp Lys Asn Glu Leu Leu Lys Ile Phe Lys Gln 
    770                 775                 780                 


Lys Met Asn Lys Asn Ile Thr Tyr Ser Asn Asp Ser Tyr Ala Phe Ile 
785                 790                 795                 800 


Ser Leu Ala Gln Phe Leu Asp Leu Lys Glu Ile Ser Asn Leu Ile His 
                805                 810                 815     


Asp Ile Lys Lys Phe Val Gln Phe Arg Glu Lys Asn Ile Leu Lys Tyr 
            820                 825                 830         


Asn Pro Glu Lys Asn Lys Ile Tyr Ile Glu Glu Leu Arg Lys Ile Leu 
        835                 840                 845             


Tyr Ile Leu Lys Val Met Leu Glu His Lys Glu Arg Val Ile Gln Lys 
    850                 855                 860                 


His Tyr Leu Gly Ser Tyr Asp Glu Asp Ile Ser Ile Met Tyr Gly Lys 
865                 870                 875                 880 


Asp Ile Glu Lys Lys Asp Ile Lys Asp Ile Glu Ile Lys Ile Lys Asn 
                885                 890                 895     


Lys Asn Gln Glu Val Ile Asn Gln Pro Leu Tyr Lys Ser Gly Asn Asp 
            900                 905                 910         


Glu Asn Ser Ser Trp Ile Ile Leu Tyr Gly Ile Glu Gln Ala Lys Arg 
        915                 920                 925             


Asn Gly Thr Phe Lys Phe Phe Glu Gly Phe Phe Asn Leu Asn Asp Asp 
    930                 935                 940                 


Ile Lys Leu Cys Lys Glu Asp Ile Glu Lys Tyr Glu Lys Leu Tyr Asn 
945                 950                 955                 960 


Glu Lys Glu Glu Asn Gln Lys Lys Val Asp Glu Tyr Ile Ser Lys Leu 
                965                 970                 975     


Asn Asn Asp Ile Glu Lys Ile Asn Asn Asp Ile Asn Ile Glu Lys Thr 
            980                 985                 990         


Asn Asp Asn Lys Gln Leu Phe Tyr  Tyr Tyr Lys Asn Met  Ile Tyr Gly 
        995                 1000                 1005             


Asp Gly  Leu Lys Lys Gly Tyr  Asp Phe Ile Asn Asp  Ile Tyr Ile 
    1010                 1015                 1020             


Tyr Tyr  Leu Ser Trp Ala Tyr  Arg Ile Glu Arg Asp  Cys Lys Ile 
    1025                 1030                 1035             


Tyr Lys  Ile Lys Glu Tyr Glu  Asn Lys Lys Asn Phe  Asn Glu Tyr 
    1040                 1045                 1050             


Lys Phe  Lys Glu Tyr Lys Ser  Ile Lys Tyr Phe Arg  Asn Glu Ile 
    1055                 1060                 1065             


Ala His  Phe Asn Tyr Phe Gln  Lys Thr Asn Lys Ser  Leu Leu Glu 
    1070                 1075                 1080             


Leu Leu  Asn Asn Phe Tyr Asp  Ile Phe Asp Tyr Asn  Leu Lys Tyr 
    1085                 1090                 1095             


Gln Arg  Asp Val Gln Lys Val  Ile Asn Asn Ile Phe  Glu Lys Tyr 
    1100                 1105                 1110             


Gln Val  Ile Arg Glu Asp Gly  Gly Pro Val Ile Phe  Tyr Cys Lys 
    1115                 1120                 1125             


Ile Asp  Lys Lys Leu Lys Leu  Ser Glu Asn Ile Ile  Pro Lys Lys 
    1130                 1135                 1140             


His Leu  Lys Cys Ser Lys Ile  Lys Leu Ile His Glu  Lys Tyr Val 
    1145                 1150                 1155             


Glu Phe  Phe Arg Lys Leu Phe  Glu Tyr Lys Lys 
    1160                 1165                 


<210>  1083
<211>  1373
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1083

Met Ala Lys His Leu Arg Pro Ile Gly Glu Ser Tyr Thr Asp Phe Leu 
1               5                   10                  15      


Asp Glu Thr Glu Phe Val Arg Leu Gly Arg Gly Leu His Arg Gly His 
            20                  25                  30          


His Gly Val Gln Ile Pro Pro Thr Glu Leu Pro Ser Tyr Leu Ala Glu 
        35                  40                  45              


Tyr Arg Lys Ala Leu Met Arg Gln Val Val Ala Val Leu Asp Lys Val 
    50                  55                  60                  


Val Gly Lys Arg Arg Arg Leu Ser Gly Met His Pro Glu Ala Tyr Arg 
65                  70                  75                  80  


Asp Arg Val His Leu Ala Glu Ala Leu Trp Val Arg Leu Val Ala Arg 
                85                  90                  95      


Val Lys Glu Ile Gly Thr Pro Pro Asp Pro Ser Glu Leu Leu Asp Leu 
            100                 105                 110         


Arg Arg Met Trp Asn Ala Lys Ala His Pro Tyr Ala Glu Tyr Asp Val 
        115                 120                 125             


Val Pro Arg Ala Pro Leu Asn Asp Gly Asn Gly Gln Lys Ile Leu Glu 
    130                 135                 140                 


Cys Arg Glu Val Asp Asp Pro Lys Ile Glu Arg Ser Asp Phe Glu Gly 
145                 150                 155                 160 


Arg Trp His Gly Arg Phe Trp Gln Ser Glu Pro Gly Pro Val Asp Tyr 
                165                 170                 175     


Asn Ala Ile Ala Asp Arg Ile Phe Ala His Leu Phe Asp Gln Glu Ala 
            180                 185                 190         


Val Ile Gly Gly Gly Pro Arg Arg Glu Gly Asn Val Thr Val Pro Asp 
        195                 200                 205             


Glu Asp Ile Asn Gly Gln Pro Gly Pro Ala Thr Gly Lys Gly Leu Ile 
    210                 215                 220                 


Ile Ala Arg Gly Gln Ser Ile Val Lys Ser Ala Ser Asp Pro Arg Arg 
225                 230                 235                 240 


Ser Ser Lys Lys Val Gln Arg Thr Trp Asp Lys Ala Val Glu Arg Arg 
                245                 250                 255     


Tyr Phe Gly Asp Asp Gly Lys Gly Gly Ser Asp Ile Ala Lys Ala Ile 
            260                 265                 270         


Tyr Glu Glu Leu Gly Asp Pro Ala Thr Leu Ala Asp Pro Ile Tyr Ala 
        275                 280                 285             


Ser Trp Phe Gly Ser Arg Leu Tyr Asp His Phe Gly Ser Phe Lys Asn 
    290                 295                 300                 


Ser Leu Pro Leu Glu Leu Lys Asp Pro Phe Lys Glu Gln Ile Trp Ala 
305                 310                 315                 320 


Leu His Asn Ser Val Arg Gln Phe Tyr Gln Arg Met Ala Lys Ser Asp 
                325                 330                 335     


Arg Phe Arg Leu Ala Leu Gln Asn Ala Arg Ser Glu Val Pro Asp Arg 
            340                 345                 350         


Ser Glu Leu Leu Ala Leu Leu Pro Lys Asp His Asp His Leu Leu Leu 
        355                 360                 365             


Val Leu Gly Gly Lys Lys Lys Asn Ala Glu Met Ser Glu Leu Ile Arg 
    370                 375                 380                 


Leu Gly Lys Leu Phe Val His Ala Ser Asp Val Leu His Asp Phe Asp 
385                 390                 395                 400 


Ala Asn Asp Ala Ala Ala Leu Asp Ala Phe Lys Arg Arg Met Ser Phe 
                405                 410                 415     


Leu Ala Thr Ser Ile Gly Gln Ser Glu Ile Lys Gln Thr Glu Thr Phe 
            420                 425                 430         


Ala Arg Thr Trp Arg Gly Ala Val Gly Leu Thr Leu Arg Thr Val Lys 
        435                 440                 445             


Gly Leu Ala Asp Pro Arg Gly Ile Ile Gly Thr Pro Asp Asn Arg Asp 
    450                 455                 460                 


Leu Gly Thr Ala Gly Pro Met Lys Asp Ala Phe Asn Lys Phe Asp Gln 
465                 470                 475                 480 


Pro His Phe Gln Gln His Met Thr Ile Ile Phe Gly Asn Lys Glu Leu 
                485                 490                 495     


Gln Ala Glu Gly Asn Pro Thr Arg Ser Ser Leu Phe Thr Ala Asn Gly 
            500                 505                 510         


Asp Lys Asp His Gln Ala Glu Leu Leu Trp Gly Phe Leu Cys Val Val 
        515                 520                 525             


Arg Ser Val Arg Asn Arg Thr Asn His Tyr Asn Val Arg Arg Ala Leu 
    530                 535                 540                 


Leu Arg Leu Leu Asp Glu Gly Ile Val Ser Pro Met Pro Ser Asp Pro 
545                 550                 555                 560 


Lys Lys Glu Arg Val Glu Asn Arg Asn Leu Cys Thr Val Ser Pro Thr 
                565                 570                 575     


Ala Leu Glu Ala Phe Arg Arg Leu Leu Asn Phe Asp Leu Ala Ile Gln 
            580                 585                 590         


Lys Glu Ala Val Arg Thr Ala Leu Glu Gln Ala Lys Ala Ser Glu Phe 
        595                 600                 605             


Val Glu Glu Gly Lys Leu Arg Gly Leu Val Ser Glu Leu Ala Gly Thr 
    610                 615                 620                 


Glu Asp Met Pro Ala Leu His Ile Pro Arg Phe Ser Ala Val Met Asp 
625                 630                 635                 640 


Lys Val Arg Arg Leu Ala Asp Asn Arg Asp Val Gly Leu Asp Pro Ile 
                645                 650                 655     


Leu Ser Thr Leu Gln Arg Ser Leu Pro Pro Thr Asp Lys Gln Ala Glu 
            660                 665                 670         


Ser Asp Ala Ala Arg Cys Arg Tyr Arg Leu Leu Leu Glu Leu Tyr Lys 
        675                 680                 685             


Ser Gly Phe Arg Ser Trp Phe Ser Gly Ile Gln Ser Asn Glu Glu Asn 
    690                 695                 700                 


Asn Arg Glu Ile Cys His Trp Ala Val Lys Gln Val Gly Arg Ala Lys 
705                 710                 715                 720 


Asp Ala Arg Lys Ser Glu Tyr Asp Lys Lys Thr Lys Arg His Tyr Arg 
                725                 730                 735     


Ser Pro Asn Ser Leu Ile Asp Asp Leu Gly Leu Asp Lys Phe Asp Asp 
            740                 745                 750         


Leu Thr Asp Leu Leu Glu Ala Leu Ala Ser Gln Ser Thr Arg Glu His 
        755                 760                 765             


Asp Gln Asn Leu Lys Tyr Val Pro Asp Ala Arg Val Gln Ser Gln Met 
    770                 775                 780                 


Ser Asn Arg Ile Glu Glu Phe Arg Gln Glu Leu Phe Ala His Ile Phe 
785                 790                 795                 800 


Thr Lys Tyr Leu Asp Thr His Asp Phe Gly Trp Ile Gly Ala Ile Glu 
                805                 810                 815     


Val Arg Arg Glu Ala Cys Asp Leu Ala Asp Val Val Ser Ala Phe Glu 
            820                 825                 830         


Val Arg Asp Gln Lys Phe Asp Ala Asp Trp His Ser Gln Phe Tyr Ala 
        835                 840                 845             


Trp Leu Tyr Met Val Pro Pro Ile Glu Ala Ser Arg Leu Arg His Gln 
    850                 855                 860                 


Met Arg Lys Ser Ala Val Met Asp Asp Lys Trp Ser Thr Thr Leu Glu 
865                 870                 875                 880 


Leu Thr Ser Gly Asp Arg Lys Thr Arg Asp Asp His Ala Gln Asp Val 
                885                 890                 895     


Leu Ala Asp Met Asp Arg Leu Phe Ser Leu Tyr Thr Lys Val Gln Ala 
            900                 905                 910         


Ala Gly Phe Asn Gly Gln Glu His Glu Ser Ala Leu Gly Ser Lys Ser 
        915                 920                 925             


Leu Phe Tyr Glu Asp Gly Asn Gln Phe Asp Glu Val Tyr Ser Pro Asp 
    930                 935                 940                 


Thr Glu Thr His Asn Lys Thr Phe Pro Gly Thr Arg Arg Gly Leu Arg 
945                 950                 955                 960 


Gln Leu Val Arg Tyr Ala His Leu Pro Ala Leu Glu Gly Val Phe Lys 
                965                 970                 975     


Lys His Arg Ile Thr Lys Ala Glu Val Glu Thr Phe Val Ala Leu Tyr 
            980                 985                 990         


Asp Glu Asn Arg Arg Asp Pro Gly  Ser Val Ala His Met  Leu Arg Arg 
        995                 1000                 1005             


Glu Lys  Leu Arg Thr Glu Ile  Leu Arg Ser Ile His  Asp Gly Pro 
    1010                 1015                 1020             


Lys Pro  Lys Asp Lys Asp Phe  Trp Pro Lys Leu Glu  Ala Lys Cys 
    1025                 1030                 1035             


Leu Glu  Tyr Arg Thr Val Ala  Thr Glu Thr Ala Ile  Tyr Asn Phe 
    1040                 1045                 1050             


Gln Ala  Asn Ala Ala Arg Leu  Asn Asp His Ala Arg  Leu His Gln 
    1055                 1060                 1065             


Ile Val  Met Arg Val Val Ala  Arg Leu Thr Asp Tyr  Ala Leu Ile 
    1070                 1075                 1080             


Trp Glu  Arg Asp Arg Leu Phe  Ala Phe Val Gly Met  Leu Tyr Arg 
    1085                 1090                 1095             


Gln Thr  Gly Gly Thr Gly Ile  Asn Pro Ala Met Arg  His Ala Glu 
    1100                 1105                 1110             


Lys Thr  Asn Ala Pro Pro Arg  Ile Gly Ile Leu Val  Ser Asp Ser 
    1115                 1120                 1125             


Ala Leu  Ala Lys Lys Leu Asn  Ser Asn Ser Ala Glu  Val Phe Ile 
    1130                 1135                 1140             


Pro Tyr  Leu Asp Thr Glu Thr  Gly Phe Asp Ala Pro  Arg Phe Asp 
    1145                 1150                 1155             


Asp Leu  Cys Thr Leu Leu Ser  His Glu His Ala Lys  Glu Phe Arg 
    1160                 1165                 1170             


Phe His  Phe Leu Glu Val Gly  Glu Glu Asn Ser Lys  Asp Glu Ala 
    1175                 1180                 1185             


Arg Arg  Leu Asn Glu Glu Thr  Met Gly His Arg Lys  Arg Pro Ala 
    1190                 1195                 1200             


Phe Lys  Arg Gly Thr Arg Arg  Gln Gly Ile Arg Asn  Asp Leu Ala 
    1205                 1210                 1215             


His His  Asn Val Leu Asp Leu  Ala Gly Gly Ala Gly  Pro Asn Leu 
    1220                 1225                 1230             


Thr Tyr  Val Val Asn Ala Val  Arg Ser Leu Leu Ser  Tyr Asp Arg 
    1235                 1240                 1245             


Lys Leu  Lys Asn Ala Val Pro  Lys Ser Ile Lys Arg  Ile Leu Gly 
    1250                 1255                 1260             


Glu Glu  Gly Leu Ile Ile Glu  Trp Gln Met Asn Tyr  Asp Arg Leu 
    1265                 1270                 1275             


Lys Lys  Pro Thr Val Tyr Pro  Asn Val Glu Thr His  Leu Thr Met 
    1280                 1285                 1290             


Val Pro  Pro Arg His Met Thr  Ala Pro Val Ser Phe  Thr Leu Pro 
    1295                 1300                 1305             


Arg Ala  Ser Val Arg Leu Ala  Ser Met Val Lys Ala  Val Phe Asp 
    1310                 1315                 1320             


Phe Gly  Ser Ser Gly Tyr Gly  Glu Glu Arg Met Ile  Gly Gly Arg 
    1325                 1330                 1335             


Thr Ala  Lys Gln Ala Val Tyr  Pro Asp Asp Phe Thr  Arg Arg Phe 
    1340                 1345                 1350             


Pro Gln  Thr Pro Met Gly Leu  Lys Gln Ala Thr Arg  Leu Val Phe 
    1355                 1360                 1365             


Ala Ser  Glu Asn Ser 
    1370             


<210>  1084
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1084

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Asn Glu Lys Asn Thr Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Tyr Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asn Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Asp Leu Asp Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Lys Ile Pro Tyr Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Ala Phe Ser Asp Gln Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Leu Lys Glu Leu Lys Glu Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asn Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Lys Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Lys  Glu Leu Cys 
    1130                 1135                 1140             


Lys Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Glu  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  1085
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1085

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Gly Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Val Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Leu Tyr Gln Ile Val  Ser Ala Phe Asn Phe  Gly Ser Lys 
    1205                 1210                 1215             


Leu Leu  Tyr Ile Ser Glu Asp  Gly Arg Trp Lys Met  Ala Gly Gly 
    1220                 1225                 1230             


Ala Phe  Pro Gly Lys Tyr Gly  Arg Phe Glu Asn Asp  Tyr Asn His 
    1235                 1240                 1245             


Arg Thr  Ser Leu Ser Lys Val  Ile Arg Leu Phe Glu  Asn Glu Ser 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ile Ile Tyr  Trp Arg Asp Tyr Val  Asp His Met 
    1265                 1270                 1275             


Lys Tyr  Tyr Val Asn Gln Asn  Gln Ser Ile Met Glu  Ile Tyr Ser 
    1280                 1285                 1290             


Ala Phe  Tyr Ser Lys Val Leu  Gly Tyr Ser Ala Lys  Leu Arg Lys 
    1295                 1300                 1305             


Ser Val  Val Phe Asn Leu Gln  Ala Ala Leu Glu Lys  His His Ile 
    1310                 1315                 1320             


Asn Pro  Glu Cys Ile Trp Met  Thr Ser Asp Gly Lys  Cys Ala Asp 
    1325                 1330                 1335             


Ile Lys  Leu Met Lys Asn Leu  Glu Ser Gln Lys Phe  Thr Tyr Lys 
    1340                 1345                 1350             


Leu Ala  Lys Arg Glu Gly Glu  Lys Thr Glu Arg Lys  Ile Cys Met 
    1355                 1360                 1365             


Asn Ala  Leu Asn Glu Asn Phe  Leu Lys Thr Ile Arg  Thr Ser Leu 
    1370                 1375                 1380             


Glu Tyr  Lys Lys 
    1385         


<210>  1086
<211>  1190
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1086

Met Leu Ile Ile Lys Pro Tyr Gly Arg Ser Gln Thr Gln Leu Ala Ser 
1               5                   10                  15      


Asp Ser Gln Arg Ile Arg Leu His Leu Pro Ser Gly Gln Ala Gln Ala 
            20                  25                  30          


Glu Pro Val Lys Glu Leu Gln Lys Asn Leu Asp Phe Val Met Ala Gln 
        35                  40                  45              


Trp Ile Ser Val Ile Asp Lys Ile Ile Ser Lys Lys Pro Pro His Tyr 
    50                  55                  60                  


Asp Lys Ser Lys Ser Arg Asp Ser Ala Thr Pro Arg Ile Ser Glu Thr 
65                  70                  75                  80  


Gln Tyr Ser Ala Arg Lys Ala Leu Gly Thr Ala Ala Leu Gln Cys Ile 
                85                  90                  95      


Glu Lys Asn Phe Gly Glu Leu Ser Val Gly Gln Arg Lys His Trp Ala 
            100                 105                 110         


Trp Lys Val His Pro Tyr Asp Cys Thr Asn Leu Ala Ala His Gln Asp 
        115                 120                 125             


Lys Asp Arg Ile Thr Gly Arg Trp Tyr Ser Gln Phe Val Gly Asp Ile 
    130                 135                 140                 


Gln Pro Thr Lys Ile Thr Leu Leu Ile Ala Glu Thr Ile Ala Gln Lys 
145                 150                 155                 160 


Ile Phe Asp His Leu Tyr Val Lys Ala Leu Arg Pro Ala Thr Ser Ile 
                165                 170                 175     


Ser Thr His Ala Gln Gly His Ser Thr His Gln Leu His Thr Ile Tyr 
            180                 185                 190         


Arg Asn Val His Ala Leu Lys Ser Pro Lys Lys Ser Thr Cys Thr Thr 
        195                 200                 205             


Ser Asp Ser Asp Leu Val Ser Asp Ser Asp Trp Glu Lys Tyr Phe Leu 
    210                 215                 220                 


Ser Gly Asp Val Val Ala Gln Ile Tyr Gln Thr Leu Asn Glu Lys Tyr 
225                 230                 235                 240 


Thr Lys Asn Asp Lys Thr Lys Ser Leu Pro Lys Ala Lys Pro Thr Thr 
                245                 250                 255     


Pro Ser Thr Gly Ser Lys Ser Pro His Leu Asn Asp Arg Ala Thr Ile 
            260                 265                 270         


Ala Lys His Leu Phe Asp His Tyr Ala Lys Val Phe Ala Ala Gln Gly 
        275                 280                 285             


Gly Ala Pro Thr Pro Val Lys Asp Leu Leu Ser Glu Thr His Pro Gln 
    290                 295                 300                 


His Ala Gln Trp Leu Val His Gln Ser Ile Lys Ala Thr Tyr Lys Ala 
305                 310                 315                 320 


Leu Phe Asp Asn Ala Ser Ile Pro Gly Leu Lys His Ile Gln His Lys 
                325                 330                 335     


Leu Pro Ala Asn Ser Ala Thr Met Arg Leu Leu Val Glu Asn Arg Arg 
            340                 345                 350         


Lys Asn His Asp Val Gly His Leu Val Arg Leu Gly Lys Val Leu His 
        355                 360                 365             


Tyr Glu Ala Ala Glu Arg Gly Lys Val Pro Ser Ala Cys Trp Ser Asp 
    370                 375                 380                 


Ile Ser Thr Pro Ala Val Ala Glu Gly Ser Ala Phe Trp Leu Ser Glu 
385                 390                 395                 400 


Gly Gln Ala Glu Ile Lys Arg Ser Glu Ala Leu Val Arg Ser Phe Lys 
                405                 410                 415     


Gln Ala Ile Thr His Ala Gly His Thr Leu Ser Gln Leu Ser Gly Trp 
            420                 425                 430         


Ala Gly Asp Ser Asp Ile Phe Leu Lys Ala Ser Lys Ala Ala Glu Gln 
        435                 440                 445             


Ala Tyr Ala Asn Thr Val Glu Gln Gln Leu Thr Leu Leu Tyr Gly Arg 
    450                 455                 460                 


Ala Cys Ser Glu Leu Phe Pro Ser Ser Tyr Ala Pro Gly Gly Asn Leu 
465                 470                 475                 480 


Lys Ala Ala Met Gln Ala Leu Leu Ala Gln Ser Ile Glu Ala Trp Ala 
                485                 490                 495     


Gln Leu Arg His Ala Ser Phe His Phe Lys Gly Lys Gln Gly Phe Leu 
            500                 505                 510         


Glu Lys Leu Gln Thr Gly Leu Ser Thr Asn Gly Thr Asn Thr Gln Glu 
        515                 520                 525             


Leu Asp Ala Val Ala Gln Lys Leu Trp Ala Gln Asp Trp Gln Gln Arg 
    530                 535                 540                 


Gln Glu Arg Ile Lys Ala Ser Leu Glu Ala Ala His Cys Leu Asp Tyr 
545                 550                 555                 560 


Leu Ser Gln Ala Gln Leu Asn Ala Ile Tyr Gln Ser Ile Ser Gly Ala 
                565                 570                 575     


Ser His Ala Arg Met Gly Ala Thr Leu Asp Met Pro Arg Leu Asn Arg 
            580                 585                 590         


Val Leu Thr Arg Ala Gln Asn Thr Ser Asp Val Gln Glu Thr Glu Lys 
        595                 600                 605             


Leu Pro Ser Pro Ala Lys Arg Gln Asp Leu Glu Asn Ser His Ala Gln 
    610                 615                 620                 


Arg Cys Arg Tyr Val Leu Leu Lys Leu Leu Tyr Glu Gln Asp Phe Ser 
625                 630                 635                 640 


Val Trp Leu Gln Asn Lys Ser His Lys Glu Val Ser Lys Trp Ile Gln 
                645                 650                 655     


Lys Ser Ile Glu Arg Ser Ser Asn Ala Ala Arg Lys Leu Asn Glu Lys 
            660                 665                 670         


Gly Leu Gln Ser Ala Asp Thr Ile His Ala Lys Ala Glu Arg Leu Trp 
        675                 680                 685             


Arg Lys Gln Ala Gln Ala Pro Thr Thr Lys Pro Ala Ser Gln Ser Asn 
    690                 695                 700                 


Pro Ile Ala Arg Phe Phe His Asp Leu Ala Ala Ala Thr Ala Ser Glu 
705                 710                 715                 720 


Phe Arg Val Gln Arg His Tyr Ala Ser Asp Ser Lys Gln Ala Gln Gln 
                725                 730                 735     


Gln Ala Ala Phe Ile Asp Asp Leu Lys Cys Asp Val Val Ala Arg Ala 
            740                 745                 750         


Phe Leu Ala Tyr Leu Arg Ser Lys Arg Pro Trp Leu Leu Gln Asp Leu 
        755                 760                 765             


Val Val Gln Asn Thr Pro Ser Arg Ile Ser Asp Leu Pro Thr Tyr Ala 
    770                 775                 780                 


Glu Glu Ser Arg His Gln Val Asp Ile Trp Gln Lys Arg Leu Tyr Phe 
785                 790                 795                 800 


Leu Leu His Met Val Pro Val Gly Val Val Ser Gln Leu Met His Gln 
                805                 810                 815     


Leu Arg Lys Trp Gln Val Leu Ser Ser Gln Ala Glu Ala Ser Lys Thr 
            820                 825                 830         


Pro Glu Asp Gln Thr Leu Tyr Ser Asn Cys Leu Gln Val Met Val Leu 
        835                 840                 845             


Tyr Leu Asp Met His Asp Ala Lys Phe Asp Gly Gly Thr Ala Ile Leu 
    850                 855                 860                 


Ile Asp Asp Thr Arg Arg Gln Thr Leu Gln Ser Cys Phe Glu Arg Glu 
865                 870                 875                 880 


Lys Asp Phe Ala Ser Cys Phe Pro Ser Asn Val Lys Pro Ser Leu Ser 
                885                 890                 895     


Gly Asp Ala His Ile Pro Leu Arg Gly Leu Arg Glu Met Leu Arg Phe 
            900                 905                 910         


Gly Gly Ala Asn Val Leu Thr Pro Val Phe Gln Gln His Pro Ile Thr 
        915                 920                 925             


Ala Ala Glu Cys Val Asn Trp Gln Glu Leu Glu Thr Lys Ile Asn Glu 
    930                 935                 940                 


Ala Gln Lys Thr Arg Glu Ala Leu His Ala Glu Trp Val Lys Asn Arg 
945                 950                 955                 960 


Lys Gly Phe Thr Lys Gln Thr Glu Tyr Glu Gln Ala Leu Asp Thr Cys 
                965                 970                 975     


Thr His His Arg His Leu Ala His Arg Val Arg Leu Val Asp His Leu 
            980                 985                 990         


Gln Leu His His Leu Leu Met Ala  Val Leu Ala Arg Leu  Ala Asp Tyr 
        995                 1000                 1005             


Ala Gly  Leu Trp Glu Arg Asp  Leu Tyr Phe Val Ser  Leu Ala Leu 
    1010                 1015                 1020             


Cys Tyr  His Lys Arg Leu Asn  Pro Ala Gln Ile Phe  Gly Glu Ser 
    1025                 1030                 1035             


Gly Lys  His Gly Asn Tyr Phe  Asp Gly Gly Glu Ile  Val Glu Ala 
    1040                 1045                 1050             


Val Arg  Lys Glu Ser Ser Cys  Asp Lys Val Ile Gln  Lys Lys Ala 
    1055                 1060                 1065             


Lys Asp  Leu Phe Gly Thr Asn  Cys Glu Arg Gly Asp  Leu Lys Val 
    1070                 1075                 1080             


Asn Ile  Arg Asn Ala Leu Ser  His Phe Asn Met Leu  Arg His Pro 
    1085                 1090                 1095             


Lys Gly  Gln Pro Asp Pro Ala  Pro Ile Asp Leu Thr  His Trp Val 
    1100                 1105                 1110             


Asn Gln  Thr Arg Cys Leu Met  Ala Tyr Asp Arg Lys  Leu Lys Asn 
    1115                 1120                 1125             


Ala Val  Ser Gln Ser Val Met  Glu Leu Leu Ala Arg  Glu Gly Leu 
    1130                 1135                 1140             


Val Leu  Thr Trp Gln Thr Asn  Ser Glu His Gln Leu  Val Leu Gln 
    1145                 1150                 1155             


Arg Val  Glu Ser Gln Lys Ile  Ala His Leu Gly Ala  Lys Gln Gly 
    1160                 1165                 1170             


Arg Glu  Ser His His Ser Glu  Ala Tyr Cys Ala Met  Val Lys Gln 
    1175                 1180                 1185             


Val Phe  
    1190 


<210>  1087
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1087

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  1088
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1088

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  1089
<211>  1245
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1089

Met Arg Ile Val Arg Pro Tyr Gly Arg Ser Phe Val Asp His Asp Pro 
1               5                   10                  15      


Gly Gly Ala Leu Gln Arg Lys Val Glu Leu Arg Ala Pro Val Ser Ala 
            20                  25                  30          


Glu Gly Gly Pro Arg Gln Leu Asp Leu Gly His Phe Ala Leu Thr His 
        35                  40                  45              


Asp Glu Leu Val Ile Ala Gln Trp Val Ser Cys Ile Asp Lys Ile Ala 
    50                  55                  60                  


Thr Lys Pro Arg Glu Gly Arg Glu Pro Ser Gly Asp Gln Arg Glu Phe 
65                  70                  75                  80  


Arg His His Leu Gly Asn Ala Ala Trp Gly His Leu Glu Thr His Gly 
                85                  90                  95      


Leu Leu Ser Gly Leu Arg Asp Pro Gln Lys Arg Ala Arg Leu Ala Lys 
            100                 105                 110         


Leu Trp Gln Met Lys Ile Ala Pro Tyr Asp Phe Ser Ala Arg Thr Arg 
        115                 120                 125             


Arg Ser Arg Gly Pro Gln Gly Val Asp Ala Pro Ala Lys Gly Arg Trp 
    130                 135                 140                 


Phe Gly Val Phe Ala Gly Asp Val Ser Val Gln Glu Ala Asp Cys Gly 
145                 150                 155                 160 


Ala Ile Val Ala Arg Ile His Glu His Leu Tyr Glu Ser Gln Tyr Arg 
                165                 170                 175     


Leu Gly Glu Glu Thr Pro Leu Arg Ser Ala Gly Leu Ile Ala Arg Arg 
            180                 185                 190         


Ala Gly Ala Ile Thr Thr Ser Val Ala Pro Asp Ala Ala Lys Pro Ser 
        195                 200                 205             


Val Ala Thr Trp Ser Glu Ala Asp Leu Ala Arg Tyr Arg Ser Ala Gly 
    210                 215                 220                 


Asp Val Ala Cys Lys Ile Arg Arg Ala Ala Arg Glu Arg Glu Gln Gly 
225                 230                 235                 240 


Arg Asp Gly Ala Gly Thr Arg Arg Val Thr Asn Ser Val Ala Gly Lys 
                245                 250                 255     


Val Leu Phe Asp His Trp Arg Ala Leu Phe Ser Asp Glu Gly Gly Thr 
            260                 265                 270         


Val Arg Ser Phe Arg Asp Val Glu Gly His Asp Pro Gly Leu Ala Ala 
        275                 280                 285             


Leu His Asn Ala Val Arg Glu Cys Tyr Ala Arg Ile Leu Lys Arg His 
    290                 295                 300                 


Lys Lys Lys Pro Pro Gly Arg Asp Ala Gly Pro Glu Ser Ser Ala Ile 
305                 310                 315                 320 


Leu Arg Ala Leu Pro Arg Asp Met Asp Ala Leu Leu Thr Arg Ile Asp 
                325                 330                 335     


Ser Gly Arg Arg Asn Arg Asp Leu Ala Ala Lys Val Arg Leu Gly Lys 
            340                 345                 350         


Leu Ile His Tyr Thr Ala Ser Asp Pro Ala His Asp Arg Ala Gly Ala 
        355                 360                 365             


Val Ala Glu Arg Trp Pro Gly Asp Val Ala Asp Ser Arg Tyr Arg Thr 
    370                 375                 380                 


Ser Ala Gly Gln Ala Glu Ile Lys Arg Asn Glu Ala Phe Val Arg Val 
385                 390                 395                 400 


Trp Arg His Val Leu Val Leu Ala Ala Arg Thr Leu Glu Asn Trp Ala 
                405                 410                 415     


Asp Pro Glu Asn Arg Ile Asn Arg Asp Ile Leu Ser Ser Gly Gly Ala 
            420                 425                 430         


Lys Ala Ala Cys Glu Gln Phe Glu Ser Ser Arg Phe Met His Lys Cys 
        435                 440                 445             


Asn Val Leu Phe Gly Glu Arg Ala Gly His Phe Ile Gly Gln Asp Asp 
    450                 455                 460                 


Ala Ala Leu Gln Lys Ala Val Leu Glu Leu Ala Leu Glu Arg Leu Gly 
465                 470                 475                 480 


Gln Leu Arg Asn Arg Ser Phe His Phe Thr Gly Arg Gly Gly Phe Leu 
                485                 490                 495     


Glu Val Leu Gln Gln Leu Gly Gln Pro Ala Glu Lys Ala Pro Cys Gln 
            500                 505                 510         


Ser Ala His Asp Arg Thr Met Ala Ser Leu Arg Ala Leu Trp Arg Asp 
        515                 520                 525             


Asp Asp Glu Gly Arg Gly Gly Arg Leu Lys Ala Thr Met Thr Gly Ala 
    530                 535                 540                 


His Phe Glu Thr Phe Leu Asp Glu Ala Gln Ile Arg Arg Phe Phe Asp 
545                 550                 555                 560 


Gln Val Ser Thr Gly Gln Glu Ala Glu Pro Pro Leu Pro Arg Phe Gly 
                565                 570                 575     


Arg Val Leu Gln Arg Ala Lys Asn Thr Arg Asp Ala Gln Ser Asp Leu 
            580                 585                 590         


Arg Pro His Leu Pro Asp Pro Gly Asn Met Arg Thr Leu Glu Asp Pro 
        595                 600                 605             


Ala Arg Leu Cys Gln Tyr Thr Ala Leu Lys Leu Leu Tyr Ala Lys Pro 
    610                 615                 620                 


Phe Arg Thr Trp Leu Ala Glu Ala Asp Ser Ala Val Ile Asn Pro Phe 
625                 630                 635                 640 


Ile Glu Ala Ala Val Thr Arg Ala Arg Arg Glu Ala Gln Lys Ile Trp 
                645                 650                 655     


Ala Ala Arg Thr Gly His His Gly Val Asp Glu Glu Ala Lys Ala Leu 
            660                 665                 670         


Ile Gln Pro Arg Met Ala Met Ile Gly Arg Leu Ala Pro Gly Glu Asn 
        675                 680                 685             


Ile Gln Thr Leu Phe Phe Arg Met Ser Ala Glu Thr Ala Thr Glu Met 
    690                 695                 700                 


Arg Val Gln Ala Gly Tyr Glu Ser Asp Pro Asp Ala Ala Arg Glu Gln 
705                 710                 715                 720 


Ala Glu Phe Ile Glu Asn Leu Lys Cys Asp Val Ile Ala Gln Ala Phe 
                725                 730                 735     


Met Arg Phe Leu Asp Glu Ala Gly Phe Asp Phe Leu Leu Thr Leu Asp 
            740                 745                 750         


Ala Arg Ala Ala Arg Pro Glu Ser Ala Arg Phe Asp Leu Ala Met Leu 
        755                 760                 765             


Asp Ala Ala Ala Arg Ala Glu Glu Pro Gln Asp Trp Met Leu Val Leu 
    770                 775                 780                 


Tyr Phe Leu Leu His Leu Val Pro Val Asp Glu Ala Gly Arg Leu Leu 
785                 790                 795                 800 


His Gln Leu Arg Lys Trp Glu Ile Leu Ala Gly Pro Glu Glu Ala Gly 
                805                 810                 815     


Ala Arg Thr Gly Ala Asp Ala Ala Asn Ser Thr Leu Ser Gly Leu Tyr 
            820                 825                 830         


Gln Val Leu Asp Leu Tyr Leu Asp Met His Asp Ala Lys Phe Ser Gly 
        835                 840                 845             


Gly Ala Ala Leu Tyr Gly Ala Arg His Phe Arg Asn Leu Phe Glu Asp 
    850                 855                 860                 


Glu Ala Asp Phe Asp Arg Leu Phe Pro Val Ala Asp Ala Gly Glu Glu 
865                 870                 875                 880 


Asp Lys Arg Ile Pro Leu Arg Gly Leu Arg Glu Ile Leu Arg Phe Gly 
                885                 890                 895     


Asp Arg Ala Thr Leu Glu Ala Ile Tyr Ala Gln Asn Arg Ile Arg Pro 
            900                 905                 910         


Ala Glu Val Ala Glu Val Leu Asp Leu Glu Ala Pro Asp Ala Asp Gly 
        915                 920                 925             


Met Ser Arg Ile Ala Gly His His Ala Arg Arg Glu Lys Leu His Ala 
    930                 935                 940                 


Gln Trp Val Glu Ala Lys Gln Ser Phe Asp Asp Asp Ala Val Arg Asp 
945                 950                 955                 960 


Tyr Phe Val Ala Leu Gly Gln Val Val Arg His Arg His Leu Ala Ala 
                965                 970                 975     


Arg Ala Arg Leu Val Asp His Val Arg Leu His Arg Leu Met Met Asn 
            980                 985                 990         


Val Leu Gly Arg Leu Ala Asp Phe  Ala Gly Leu Trp Glu  Arg Asp Val 
        995                 1000                 1005             


Tyr Phe  Val Met Leu Ala Thr  Leu Tyr Glu Gln Gly  Thr Ser Pro 
    1010                 1015                 1020             


Ala Ala  Val Leu Asn Cys Glu  Ala Arg Arg Lys Leu  Ser Gln Gly 
    1025                 1030                 1035             


Arg Ile  Val Glu Val Ile Arg  Ala Leu Lys Pro Val  Asp Gly Gly 
    1040                 1045                 1050             


Ala Leu  Tyr Ala Ala Ile Thr  Gly His Phe Pro Gly  Phe Asp Thr 
    1055                 1060                 1065             


Arg Arg  Asn Asp Asp Pro Val  Gln Leu Arg Asn Asn  Phe Ala His 
    1070                 1075                 1080             


Phe Asn  Met Leu Arg Gln Gly  His Met Pro Asp Leu  Thr Ala Cys 
    1085                 1090                 1095             


Val Asn  Arg Ala Arg Arg Leu  Met Ala Tyr Asp Arg  Lys Leu Lys 
    1100                 1105                 1110             


Asn Ala  Val Ser Lys Ala Val  Ile Glu Leu Leu Ala  Arg Glu Gly 
    1115                 1120                 1125             


Leu Thr  Leu Ser Trp Arg Met  Asp Ala Arg Gly Pro  Gln His Asp 
    1130                 1135                 1140             


Leu Thr  Glu Ala Arg Ile Thr  Ala Arg Thr Ala Thr  His Leu Gly 
    1145                 1150                 1155             


Gly Ile  Arg Leu Thr Gln Arg  Gly Gly Ser Thr Gly  Ser Arg Pro 
    1160                 1165                 1170             


Phe Pro  Leu Thr Glu Ala Leu  His Gly Thr Gly Phe  Ala Arg Met 
    1175                 1180                 1185             


Val Ala  Gln Leu Phe Ala Gly  Gln Asp Arg Pro Ser  Arg Cys Val 
    1190                 1195                 1200             


Ser Gln  Asp Asp Pro Thr Thr  Ile Glu Arg Ala Pro  Ala Arg Asn 
    1205                 1210                 1215             


Thr Asn  Arg Lys Glu Ser Ala  Lys Lys Arg Met Lys  Pro Gly Arg 
    1220                 1225                 1230             


Asp Gly  Gly Arg Arg His Glu  Lys Ser Arg Arg Gly  
    1235                 1240                 1245 


<210>  1090
<211>  1245
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1090

Met Arg Ile Val Arg Pro Tyr Gly Arg Ser Phe Val Asp His Asp Pro 
1               5                   10                  15      


Gly Gly Ala Leu Gln Arg Lys Val Glu Leu Arg Ala Pro Val Ser Ala 
            20                  25                  30          


Glu Gly Gly Pro Arg Gln Leu Asp Leu Gly His Phe Ala Leu Thr His 
        35                  40                  45              


Asp Glu Leu Val Ile Ala Gln Trp Val Ser Cys Ile Asp Lys Ile Ala 
    50                  55                  60                  


Thr Lys Pro Arg Glu Gly Arg Glu Pro Ser Gly Asp Gln Arg Glu Phe 
65                  70                  75                  80  


Arg His His Leu Gly Asn Ala Ala Trp Gly His Leu Glu Thr His Gly 
                85                  90                  95      


Leu Leu Ser Gly Leu Arg Asp Pro Gln Lys Arg Ala Arg Leu Ala Lys 
            100                 105                 110         


Leu Trp Gln Met Lys Ile Ala Pro Tyr Asp Phe Ser Ala Arg Thr Arg 
        115                 120                 125             


Arg Ser Arg Gly Pro Gln Gly Val Asp Ala Pro Ala Lys Gly Arg Trp 
    130                 135                 140                 


Phe Gly Val Phe Ala Gly Asp Val Ser Val Gln Glu Ala Asp Cys Gly 
145                 150                 155                 160 


Ala Ile Val Ala Arg Ile His Glu His Leu Tyr Glu Ser Gln Tyr Arg 
                165                 170                 175     


Leu Gly Glu Glu Thr Pro Leu Arg Ser Ala Gly Leu Ile Ala Arg Arg 
            180                 185                 190         


Ala Gly Ala Ile Thr Thr Ser Val Ala Pro Asp Ala Ala Lys Pro Ser 
        195                 200                 205             


Val Ala Thr Trp Ser Glu Ala Asp Leu Ala Arg Tyr Arg Ser Ala Gly 
    210                 215                 220                 


Asp Val Ala Cys Lys Ile Arg Arg Ala Ala Arg Glu Arg Glu Gln Gly 
225                 230                 235                 240 


Arg Asp Gly Ala Gly Thr Arg Arg Val Thr Asn Ser Val Ala Gly Lys 
                245                 250                 255     


Val Leu Phe Asp His Trp Arg Ala Leu Phe Ser Asp Glu Gly Gly Thr 
            260                 265                 270         


Val Arg Ser Phe Arg Asp Val Glu Gly His Asp Pro Gly Leu Ala Ala 
        275                 280                 285             


Leu His Asn Ala Val Arg Glu Cys Tyr Ala Arg Ile Leu Lys Arg His 
    290                 295                 300                 


Lys Lys Lys Pro Pro Gly Arg Asp Ala Gly Pro Glu Ser Ser Ala Ile 
305                 310                 315                 320 


Leu Arg Ala Leu Pro Arg Asp Met Asp Ala Leu Leu Thr Arg Ile Asp 
                325                 330                 335     


Ser Gly Arg Arg Asn Arg Asp Leu Ala Ala Lys Val Arg Leu Gly Lys 
            340                 345                 350         


Leu Ile His Tyr Thr Ala Ser Asp Pro Ala His Asp Arg Ala Gly Ala 
        355                 360                 365             


Val Ala Glu Arg Trp Pro Gly Asp Val Ala Asp Ser Arg Tyr Arg Thr 
    370                 375                 380                 


Ser Ala Gly Gln Ala Glu Ile Lys Arg Asn Glu Ala Phe Val Arg Val 
385                 390                 395                 400 


Trp Arg His Val Leu Val Leu Ala Ala Arg Thr Leu Glu Asn Trp Ala 
                405                 410                 415     


Asp Pro Glu Asn Arg Ile Asn Arg Asp Ile Leu Ser Ser Gly Gly Ala 
            420                 425                 430         


Lys Ala Ala Cys Glu Gln Phe Glu Ser Ser Arg Phe Met His Lys Cys 
        435                 440                 445             


Asn Val Leu Phe Gly Glu Arg Ala Gly His Phe Ile Gly Gln Asp Asp 
    450                 455                 460                 


Ala Ala Leu Gln Lys Ala Val Leu Glu Leu Ala Leu Glu Arg Leu Gly 
465                 470                 475                 480 


Gln Leu Arg Asn Arg Ser Phe His Phe Thr Gly Arg Gly Gly Phe Leu 
                485                 490                 495     


Glu Val Leu Gln Gln Leu Gly Gln Pro Ala Glu Lys Ala Pro Cys Gln 
            500                 505                 510         


Ser Ala His Asp Arg Thr Met Ala Ser Leu Arg Ala Leu Trp Arg Asp 
        515                 520                 525             


Asp Asp Glu Gly Arg Gly Gly Arg Leu Lys Ala Thr Met Thr Gly Ala 
    530                 535                 540                 


His Phe Glu Thr Phe Leu Asp Glu Ala Gln Ile Arg Arg Phe Phe Asp 
545                 550                 555                 560 


Gln Val Ser Thr Gly Gln Glu Ala Glu Pro Pro Leu Pro Arg Phe Gly 
                565                 570                 575     


Arg Val Leu Gln Arg Ala Lys Asn Thr Arg Asp Ala Gln Ser Asp Leu 
            580                 585                 590         


Arg Pro His Leu Pro Asp Pro Gly Asn Met Arg Thr Leu Glu Asp Pro 
        595                 600                 605             


Ala Arg Leu Cys Gln Tyr Thr Ala Leu Lys Leu Leu Tyr Ala Lys Pro 
    610                 615                 620                 


Phe Arg Thr Trp Leu Ala Glu Ala Asp Ser Ala Val Ile Asn Pro Phe 
625                 630                 635                 640 


Ile Glu Ala Ala Val Thr Arg Ala Arg Arg Glu Ala Gln Lys Ile Trp 
                645                 650                 655     


Ala Ala Arg Thr Gly His His Gly Val Asp Glu Glu Ala Lys Ala Leu 
            660                 665                 670         


Ile Gln Pro Arg Met Ala Met Ile Gly Arg Leu Ala Pro Gly Glu Asn 
        675                 680                 685             


Ile Gln Thr Leu Phe Phe Arg Met Ser Ala Glu Thr Ala Thr Glu Met 
    690                 695                 700                 


Arg Val Gln Ala Gly Tyr Glu Ser Asp Pro Asp Ala Ala Arg Glu Gln 
705                 710                 715                 720 


Ala Glu Phe Ile Glu Asn Leu Lys Cys Asp Val Ile Ala Gln Ala Phe 
                725                 730                 735     


Met Arg Phe Leu Asp Glu Ala Gly Phe Asp Phe Leu Leu Thr Leu Asp 
            740                 745                 750         


Ala Arg Ala Ala Arg Pro Glu Ser Ala Arg Phe Asp Leu Ala Met Leu 
        755                 760                 765             


Asp Ala Ala Ala Arg Ala Glu Glu Pro Gln Asp Trp Met Leu Val Leu 
    770                 775                 780                 


Tyr Phe Leu Leu His Leu Val Pro Val Asp Glu Ala Gly Arg Leu Leu 
785                 790                 795                 800 


His Gln Leu Arg Lys Trp Glu Ile Leu Ala Gly Pro Glu Glu Ala Gly 
                805                 810                 815     


Ala Arg Thr Gly Ala Asp Ala Ala Asn Ser Thr Leu Ser Gly Leu Tyr 
            820                 825                 830         


Gln Val Leu Asp Leu Tyr Leu Asp Met His Asp Ala Lys Phe Ser Gly 
        835                 840                 845             


Gly Ala Ala Leu Tyr Gly Ala Arg His Phe Arg Asn Leu Phe Glu Asp 
    850                 855                 860                 


Glu Ala Asp Phe Asp Arg Leu Phe Pro Val Ala Asp Ala Gly Glu Glu 
865                 870                 875                 880 


Asp Lys Arg Ile Pro Leu Arg Gly Leu Arg Glu Ile Leu Arg Phe Gly 
                885                 890                 895     


Asp Arg Ala Thr Leu Glu Ala Ile Tyr Ala Gln Asn Arg Ile Arg Pro 
            900                 905                 910         


Ala Glu Val Ala Glu Val Leu Asp Leu Glu Ala Pro Asp Ala Asp Gly 
        915                 920                 925             


Met Ser Arg Ile Ala Gly His His Ala Arg Arg Glu Lys Leu His Ala 
    930                 935                 940                 


Gln Trp Val Glu Ala Lys Gln Ser Phe Asp Asp Asp Ala Val Arg Asp 
945                 950                 955                 960 


Tyr Phe Val Ala Leu Gly Gln Val Val Arg His Arg His Leu Ala Ala 
                965                 970                 975     


Arg Ala Arg Leu Val Asp His Val Arg Leu His Arg Leu Met Met Asn 
            980                 985                 990         


Val Leu Gly Arg Leu Ala Asp Phe  Ala Gly Leu Trp Glu  Arg Asp Val 
        995                 1000                 1005             


Tyr Phe  Val Met Leu Ala Thr  Leu Tyr Glu Gln Gly  Thr Ser Pro 
    1010                 1015                 1020             


Ala Ala  Val Leu Asn Cys Glu  Ala Arg Arg Lys Leu  Ser Gln Gly 
    1025                 1030                 1035             


Arg Ile  Val Glu Val Ile Arg  Ala Leu Lys Pro Val  Asp Gly Gly 
    1040                 1045                 1050             


Ala Leu  Tyr Ala Ala Ile Thr  Gly His Phe Pro Gly  Phe Asp Thr 
    1055                 1060                 1065             


Arg Arg  Asn Asp Asp Pro Val  Gln Leu Arg Asn Asn  Phe Ala His 
    1070                 1075                 1080             


Phe Asn  Met Leu Arg Gln Gly  His Met Pro Asp Leu  Thr Ala Cys 
    1085                 1090                 1095             


Val Asn  Arg Ala Arg Arg Leu  Met Ala Tyr Asp Arg  Lys Leu Lys 
    1100                 1105                 1110             


Asn Ala  Val Ser Lys Ala Val  Ile Glu Leu Leu Ala  Arg Glu Gly 
    1115                 1120                 1125             


Leu Thr  Leu Ser Trp Arg Met  Asp Ala Arg Gly Pro  Gln His Asp 
    1130                 1135                 1140             


Leu Thr  Glu Ala Arg Ile Thr  Ala Arg Thr Ala Thr  His Leu Gly 
    1145                 1150                 1155             


Gly Ile  Arg Leu Thr Gln Arg  Gly Gly Ser Thr Gly  Ser Arg Pro 
    1160                 1165                 1170             


Phe Pro  Leu Thr Glu Ala Leu  His Gly Thr Gly Phe  Ala Arg Met 
    1175                 1180                 1185             


Val Ala  Gln Leu Phe Ala Gly  Gln Asp Arg Pro Ser  Arg Cys Val 
    1190                 1195                 1200             


Ser Gln  Asp Asp Pro Thr Thr  Ile Glu Arg Ala Pro  Ala Arg Asn 
    1205                 1210                 1215             


Thr Asn  Arg Lys Glu Ser Ala  Lys Lys Arg Met Lys  Pro Gly Arg 
    1220                 1225                 1230             


Asp Gly  Gly Arg Arg His Glu  Lys Ser Arg Arg Gly  
    1235                 1240                 1245 


<210>  1091
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1091

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Thr Glu Asn Lys Asn Glu Glu Gln Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Arg Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Leu Lys Lys Asn Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Lys Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Cys Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Ile Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Gln Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Ala Leu Glu Gly Glu Ser 
    450                 455                 460                 


Val Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Glu Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Ala Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Arg Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Lys Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Lys Gly Asp Lys Glu Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Glu Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Ser Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Lys Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Glu Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Val Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Thr Gln  
    1355                 1360 


<210>  1092
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1092

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  1093
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1093

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  1094
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1094

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys His Lys 
    210                 215                 220                 


Ile Arg Gly Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Val 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Lys Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Ser Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Lys Ile Leu Lys Tyr Thr Glu Ser Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Gln Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asp 
            820                 825                 830         


Lys Val Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Lys Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Arg Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Lys 
        915                 920                 925             


Lys Tyr Glu Lys Ala Ile Arg Asn Ile Gln Gln Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Arg Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Glu Asn Lys  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Lys Phe Tyr Lys Glu  Leu His Gln 
    1010                 1015                 1020             


Asn Asp  Glu Val Lys Ile Asn  Lys Tyr Ser Ser Val  Asn Ile Lys 
    1025                 1030                 1035             


Val Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Ile Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Thr Lys Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Glu 
    1100                 1105                 1110             


Ile Gln  Ser Leu Lys Ser Glu  Glu Ile Val His Leu  Lys Lys Leu 
    1115                 1120                 1125             


Lys Leu  Lys Asp Asn Asp Lys  Lys Lys Glu Pro Ile  Lys Thr Tyr 
    1130                 1135                 1140             


Arg Asn  Ser Lys Glu Leu Cys  Glu Leu Val Lys Ile  Met Phe Glu 
    1145                 1150                 1155             


Tyr Lys  Met Glu Glu Lys Lys  Ser Glu Asn 
    1160                 1165             


<210>  1095
<211>  1195
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1095

Met Lys Leu Thr Lys Ser Lys Asn Ala Gln Glu Ala Phe Phe Tyr Arg 
1               5                   10                  15      


Asn Thr His Met Gly Lys Leu Tyr Met Arg Ser Ala Phe Ser Glu Asp 
            20                  25                  30          


Lys Thr Asp Ser Thr Ile Asp Asn Leu Pro Phe Lys Glu Ser Leu Ala 
        35                  40                  45              


Arg Arg Ile Leu Leu Arg Cys Asp Lys Thr Lys Ser His Lys Gln Asn 
    50                  55                  60                  


Pro Phe Lys Ser Phe Met Glu Glu Leu Ile Asp Lys Glu Lys Ala Val 
65                  70                  75                  80  


Leu Pro Ser Lys Glu Val Ile Gly Tyr Asp Lys Thr Phe Gln Ala Val 
                85                  90                  95      


Arg Tyr Phe Ser Pro Tyr Gly Arg Ala Leu Arg Ile Gly Gln Gly Gly 
            100                 105                 110         


Asn Gly Ile Thr Phe Glu Lys Leu Leu Ile Glu His Tyr Asp Asn Asn 
        115                 120                 125             


Lys Asp Ile Ser Glu Glu Leu Lys Lys Ile Ser Ala Met Leu Lys Leu 
    130                 135                 140                 


Arg Arg Thr Tyr Lys Lys Asp His Leu Lys Lys Ser Ile Lys Asn Asn 
145                 150                 155                 160 


Lys Ile Val Phe Pro Leu Val Ile Asn Glu Ala Asn Thr Ser Lys Ile 
                165                 170                 175     


Gly Lys Gly Glu Trp Leu Leu Asp Phe Ile Asn Asn Glu Lys Lys Phe 
            180                 185                 190         


Thr Asp Tyr Lys Asn Trp Tyr Asp Tyr Ala Lys Leu Tyr Glu Thr Lys 
        195                 200                 205             


Leu Lys Pro Leu Gln Thr Asn Leu Gly Tyr Leu Lys Asn Pro Gln Val 
    210                 215                 220                 


Trp Gly Gly Leu Leu Tyr Ala Glu Val Lys Lys Tyr His His Glu Leu 
225                 230                 235                 240 


Tyr Lys Thr Lys Lys Ser Glu Leu Asn Cys Glu Lys Lys Leu Gln Glu 
                245                 250                 255     


Phe Gly Phe Tyr Leu Asn Glu Val Gln Asp Tyr Phe Arg His Tyr Phe 
            260                 265                 270         


Gly Ser Ser Lys Ala Gly Lys Ser Leu Asn Lys Ala Ala Lys Ile Asp 
        275                 280                 285             


Arg Leu Ile Glu Ile Lys Glu Gly Ala Val Glu Glu Ser Tyr Met Tyr 
    290                 295                 300                 


Lys Trp Ile Lys Ala His Ile Thr Asn Lys Ile Thr Ala Leu Leu Ile 
305                 310                 315                 320 


Gln Asn Gly Lys Phe Met His Tyr Lys Val Glu His Pro Thr Ser Asp 
                325                 330                 335     


Ile Leu Ser Asn Ile Gln Ile Glu Glu Ser Phe Lys Lys Gln Leu Phe 
            340                 345                 350         


Leu Ser Ile Ala Trp Ala Thr Thr Arg Leu Asn Tyr Phe Phe Asp Tyr 
        355                 360                 365             


Gly Ser Asn Asn Asp Val Leu Leu Gly Glu Pro Lys Asn Asn Ser Thr 
    370                 375                 380                 


Val Gly Thr Asn Ile Gln Gly Asp Ile Leu Ser Glu Phe Asp Glu Asp 
385                 390                 395                 400 


Thr Thr Leu Lys Asn Ile Tyr Gln Lys Asn Ile Lys Asn Thr Lys Ala 
                405                 410                 415     


Tyr Met Glu Tyr Phe Leu Ala Glu Leu Lys Lys Ser Glu Asn Asn Asn 
            420                 425                 430         


Lys Asn Val Phe Gln Glu Lys Val Cys Thr Thr Phe Pro Ile His Ile 
        435                 440                 445             


Gln Glu Asn Asn Ser Asp Asp Thr Ile Glu Ala Leu Leu Asp Ile Leu 
    450                 455                 460                 


Asp Ala Ala Lys Glu Ser Ile Ser Tyr Leu Arg Asn Asn Val Phe His 
465                 470                 475                 480 


Pro Gln Lys Glu Tyr Leu Tyr Glu Leu Thr Leu Pro Glu Lys Ile Lys 
                485                 490                 495     


Gly Ile Val Glu Lys Asp Tyr Phe Ala Lys Thr Lys Glu Val Met Lys 
            500                 505                 510         


Thr Asp Ile Ser Gln Ile Asn Ser Cys Phe Lys Glu Lys Ile Arg Ser 
        515                 520                 525             


Ala Leu Ile Ala Asp Val Tyr Pro Leu Glu Ile Leu Gln Asn Leu Phe 
    530                 535                 540                 


Thr Asn Cys Lys Leu Ser Phe Tyr Leu Tyr Ala Pro Lys Tyr Glu Leu 
545                 550                 555                 560 


Met Pro Ala Phe Arg Lys Val Tyr Gln Arg Gly Ala Asn Leu Cys Ser 
                565                 570                 575     


Gln Gly Gly Thr Gln Arg Asn Leu Ser Trp Phe Tyr Asn Lys Pro Val 
            580                 585                 590         


Val Ser Arg Gly Ala Asp Gly Leu Arg Asp Ile Asn Asp Ile Lys Gln 
        595                 600                 605             


Trp Gln Ala Tyr Lys Asn Leu Leu Gln Met Ile Tyr Glu His Ser Phe 
    610                 615                 620                 


Leu Pro Ala Val His Glu Asp Glu Ser Leu Ile Thr Lys Tyr Ile Tyr 
625                 630                 635                 640 


Glu Thr Ile Gln Gln Ser Gln Glu Ala Ser Arg Asp Arg Asn Lys Glu 
                645                 650                 655     


Tyr Cys Phe Arg Tyr Arg Asn Met Pro Lys Tyr Lys Ser Ser Ser Leu 
            660                 665                 670         


Ala Ala Tyr Met Ser Asn Leu Gln Arg Leu Gln Ser Ala Glu Glu Ser 
        675                 680                 685             


Asn Gln His Asp Asp Thr Lys Ser Lys Thr Asp Asn Lys Asn Tyr Tyr 
    690                 695                 700                 


Ile Asp Phe Val Gln Asp Phe Phe Val Arg Ala Phe Asp Arg Tyr Leu 
705                 710                 715                 720 


Glu Gly His Leu Ser Ser Ile Lys Arg Tyr Leu Leu Pro Asp Ala Gly 
                725                 730                 735     


Asn Lys Leu His Val Thr Glu Lys Glu Asp Val Glu Thr Thr Leu Ser 
            740                 745                 750         


Gln Leu Phe Gln Lys Glu Asn Pro Thr Ile Cys Met Lys Asp Ala Asn 
        755                 760                 765             


Val Ile Asn Glu Asn Asp Glu Phe Cys Leu Leu Phe Tyr Pro Phe Leu 
    770                 775                 780                 


Arg Met Leu Glu Arg Arg Glu Leu Ser Asn Leu Gln His Gln Val Ile 
785                 790                 795                 800 


Arg Tyr Arg Cys Ser Phe Lys His Arg Leu Ser Ile Glu Val Asp Ser 
                805                 810                 815     


Ser Glu Lys Leu Glu Arg Leu Ile Ala Met Leu Ile Phe Thr Phe Pro 
            820                 825                 830         


Asp His Ile Asp Glu Glu Asp Cys Tyr Lys Asp Met Val Lys Lys Tyr 
        835                 840                 845             


Phe Gly Lys Phe Val Glu Gly Ser Leu Lys Asp Tyr Leu Asp Leu Tyr 
    850                 855                 860                 


Phe Gln Ser Gly Glu Lys Leu Ile Gln Gln Lys Ser Met Leu Ala Leu 
865                 870                 875                 880 


Met Arg Thr Gly Ser Met Ala Leu Tyr Ser Glu Met Phe Ser Pro Ile 
                885                 890                 895     


Tyr Lys Ile Thr Ser Glu Asp Tyr Asn Lys Tyr Lys Ser Tyr Cys Gln 
            900                 905                 910         


Leu Gly Glu Asn Pro Gly Gly Lys Gln Leu Ser Pro Ile Glu Gln Ala 
        915                 920                 925             


Gln Gln Gln Leu Ala Ser Leu His Gln Glu Leu Cys Glu Glu Lys Ser 
    930                 935                 940                 


Ile Ser Lys Asp Asn Glu Lys Leu Arg Lys Tyr Lys Glu Cys Leu Val 
945                 950                 955                 960 


Leu Val His Glu Tyr Ser Glu Leu Arg Arg Lys Leu Thr Phe Asp Leu 
                965                 970                 975     


Leu Tyr Glu Ile His Leu Ile His Val Asp Ile Leu Gly Arg Phe Ala 
            980                 985                 990         


Ser Phe Ala Ala Asp Trp Glu Arg  Asp Met His Phe Leu  Leu Leu Gly 
        995                 1000                 1005             


Leu Tyr  Gly Leu Gly Gln Gln  Asn Gln Ile Asp Lys  Leu Leu Ser 
    1010                 1015                 1020             


Phe Lys  Ser Gln Glu Glu Val  Asp Asn Ile Phe Arg  Tyr Met Arg 
    1025                 1030                 1035             


Arg Glu  Lys Ser Met Thr Ala  Lys Phe Lys Asn Ala  Leu Lys Asn 
    1040                 1045                 1050             


Glu Ile  Asn Arg Lys Thr Leu  Glu Glu Leu Cys Leu  Tyr Asn Cys 
    1055                 1060                 1065             


Gln Asp  Gly Leu Asp Lys Val  Ile Asn Val Arg Asn  Thr Leu Ala 
    1070                 1075                 1080             


His Leu  Asn His Met Thr Gln  Ile Ser Tyr Lys Asn  Glu Tyr Gln 
    1085                 1090                 1095             


Lys Ser  Ile Phe Glu Leu Leu  Thr Ala Ile Ser Lys  Leu Leu Asn 
    1100                 1105                 1110             


Tyr Asp  Leu Lys Arg Lys Asn  Ser Val Thr Arg Val  Leu Lys Ala 
    1115                 1120                 1125             


Leu Leu  Asn Lys Tyr His Ile  Lys Leu Ser Leu Tyr  Gln Lys Asn 
    1130                 1135                 1140             


Asp Asp  Tyr Glu Cys Ile Ser  Ile Lys Ser Glu Glu  Ile Val His 
    1145                 1150                 1155             


Leu Lys  Asn Leu Arg Ile Arg  Glu Asn Lys Lys Arg  Ile Glu Leu 
    1160                 1165                 1170             


Pro Ala  Gln Asp Val Leu Phe  Val Glu Cys Val Ala  Lys Leu Leu 
    1175                 1180                 1185             


Asp Phe  Ser Tyr Asn Lys Lys  
    1190                 1195 


<210>  1096
<211>  1191
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1096

Met Lys Val Thr Lys Ile Asp Gly Leu Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ile Glu Asp Ala Ser Gln Lys Asn Glu Thr 
            20                  25                  30          


Leu Glu Arg Leu Glu Asn Leu Lys Gly Ile Lys Leu Gly Ser Tyr Ile 
        35                  40                  45              


Lys Asn Pro Asp Lys Thr Lys Asn Lys Asp Asn Lys Lys Arg Arg Lys 
    50                  55                  60                  


Gly Leu Lys Glu Tyr Phe Ser Glu Ile Thr Leu Arg Lys Glu Asn Glu 
65                  70                  75                  80  


Lys Tyr Val Leu Leu Lys Gly Lys Lys Leu Lys Lys Ile Asn Asn Asp 
                85                  90                  95      


Ile Lys Asp Thr Asp Ile Lys Ala Lys Asp Lys Lys Glu Glu Val Phe 
            100                 105                 110         


Asp Ile Leu Lys Glu Ile Leu Lys Leu Asn Leu Leu Ala Asn Asp Ala 
        115                 120                 125             


Glu Glu Lys Ile Gln Phe Asp Ser Ile Lys Leu Lys Asn Val Phe Gly 
    130                 135                 140                 


Lys Asp Phe Ala Lys Lys Glu Leu Gln Ile Lys Ser Ile Glu Glu Ser 
145                 150                 155                 160 


Leu Glu Lys Asn Arg Ala Asp Tyr Arg Lys Glu Phe Ile Glu Ile Glu 
                165                 170                 175     


Asn His Lys Tyr Gly Asn Val Lys Gly Lys Asn Lys Arg Ser Arg Ile 
            180                 185                 190         


Tyr Glu Tyr Tyr Lys Lys Ser Glu Asn His Lys Lys Phe Glu Asp Asn 
        195                 200                 205             


Ile Arg Glu Ala Phe Glu Lys Leu Tyr Thr Glu Glu Asn Ile Lys Lys 
    210                 215                 220                 


Leu Tyr Ser Lys Ile Glu Glu Val Leu Lys Lys Thr His Leu Lys Ser 
225                 230                 235                 240 


Ile Val Arg Glu Phe Tyr Lys Asn Glu Ile Ile Gly Glu Ser Glu Phe 
                245                 250                 255     


Ser Lys Lys Asn Gly Asp Gly Ile Ser Ile Leu Tyr Asn Gln Ile Lys 
            260                 265                 270         


Asp Ser Ile Lys Lys Glu Glu Asn Phe Ile Glu Phe Ile Glu Asn Ile 
        275                 280                 285             


Gly Asn Leu Glu Leu Lys Asp Leu Thr Lys Ser Gln Ile Phe Tyr Lys 
    290                 295                 300                 


Tyr Phe Leu Glu Asn Glu Glu Leu Asn Asp Glu Asn Ile Lys Phe Val 
305                 310                 315                 320 


Phe Cys Tyr Phe Val Glu Ile Glu Val Ser Asp Leu Leu Lys Gly Asn 
                325                 330                 335     


Val Tyr Lys Val Ser Lys Ile Tyr Glu Asn Lys Ile Lys Asn Ile Phe 
            340                 345                 350         


Glu Tyr Asp Lys Leu Lys Lys Leu Val Ile Asn Lys Leu Glu Asn Lys 
        355                 360                 365             


Leu Asn Asn Tyr Val Arg Asn Cys Gly Lys Tyr Asn Tyr His Met Glu 
    370                 375                 380                 


Asn Gly Asp Ile Ala Thr Ser Asp Ile Asn Met Arg Asn Arg Gln Thr 
385                 390                 395                 400 


Glu Ala Phe Leu Arg Ser Met Ile Gly Val Ser Ser Phe Gly Tyr Phe 
                405                 410                 415     


Ser Leu Arg Asn Ile Leu Gly Val Asn Asp Asp Asp Phe Tyr Glu Ile 
            420                 425                 430         


Glu Glu Asp Leu Thr Glu Glu Glu Arg Lys Asn Glu Ser Asn Val Leu 
        435                 440                 445             


Lys Lys Val Lys Glu Asp Ile Ala Ser Lys Ser Ile Phe Glu Lys Val 
    450                 455                 460                 


Val Asp Lys Ser Phe Gln Lys Lys Gly Ile Tyr Asn Ile Lys Glu Asn 
465                 470                 475                 480 


Leu Lys Met Phe Tyr Gly Asp Ser Phe Asp Asp Ala Asp Glu Asp Glu 
                485                 490                 495     


Leu Lys Gln Phe Phe Val Asn Met Leu Asn Ala Ile Thr Ser Ile Arg 
            500                 505                 510         


His Arg Val Val His Tyr Ser Met Asn Thr Asn Ser Glu Asn Ile Phe 
        515                 520                 525             


Asn Phe Ser Asp Ile Glu Val Ser Arg Leu Leu Lys Ser Ile Phe Glu 
    530                 535                 540                 


Lys Glu Thr Asp Lys Arg Glu Leu Lys Leu Lys Ile Phe Arg Gln Leu 
545                 550                 555                 560 


Asn Ser Ala Gly Val Phe Asp Tyr Trp Glu Asn Trp Glu Ile Glu Lys 
                565                 570                 575     


Tyr Leu Glu Asn Ile Lys Phe Glu Phe Val Asn Lys Asn Ile Pro Phe 
            580                 585                 590         


Val Pro Ser Phe Thr Lys Leu Tyr Asn Arg Ile Asp Asn Leu Lys Gly 
        595                 600                 605             


Ser Asn Ala Leu Asn Leu Gly Phe Ile Asn Ile Pro Lys Arg Lys Glu 
    610                 615                 620                 


Ala Arg Asp Ser Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu 
625                 630                 635                 640 


Phe Val Glu Lys Phe Val Asp Asn Asn Asp Asn Phe Glu Lys Ile Phe 
                645                 650                 655     


Arg Glu Ile Ile Glu Ile Asn Lys Asn Ala Gly Thr Asn Thr Lys Thr 
            660                 665                 670         


Lys Phe Tyr Lys Leu Glu Lys Phe Glu Thr Leu Lys Ala Asn Thr Pro 
        675                 680                 685             


Thr Glu Tyr Leu Glu Lys Leu Gln Ser Leu His Gln Ile Asn Tyr Asp 
    690                 695                 700                 


Arg Glu Lys Ile Glu Gly Asp Lys Asp Ile Tyr Val Asp Phe Val Gln 
705                 710                 715                 720 


Lys Ile Phe Leu Lys Gly Phe Ile Asn Tyr Leu Gln Lys Ser Asn Ser 
                725                 730                 735     


Leu Lys Pro Leu Asn Leu Leu Asn Leu Lys Lys Asp Glu Val Ile Asn 
            740                 745                 750         


Ser Glu Lys Ser Ser Tyr Asp Glu Lys Leu Lys Gln Trp Glu Asn Asn 
        755                 760                 765             


Gly Ser Lys Leu Ser Glu Met Pro Lys Glu Ile Tyr Lys Tyr Ile Lys 
    770                 775                 780                 


Glu Ile Asn Ile Asn Glu Thr Asn Tyr Ser Asp Arg Met Ser Ile Phe 
785                 790                 795                 800 


Tyr Leu Leu Leu Lys Leu Ile Asp His Lys Glu Leu Thr Asn Leu Arg 
                805                 810                 815     


Gly Asn Leu Glu Lys Tyr Glu Ser Met Asn Lys Asn Lys Ile Tyr Ser 
            820                 825                 830         


Glu Glu Leu Asn Ile Val Asn Leu Val Ser Leu Asp Asn Asn Lys Val 
        835                 840                 845             


Arg Thr Asn Phe Ser Val Glu Ala Glu Asp Ile Gly Lys Phe Leu Lys 
    850                 855                 860                 


Thr Glu Thr Leu Ile Lys Asp Ala Arg Gln Leu Asn Asn Phe Ser Glu 
865                 870                 875                 880 


Arg Phe Ser Asp Gly Glu Asn Val Ile Lys His Arg Ser Phe Tyr Asn 
                885                 890                 895     


Ile Lys Lys Tyr Gly Ile Leu Asp Leu Leu Glu Lys Ile Val Ala Lys 
            900                 905                 910         


Ala Asp Leu Lys Ile Ala Lys Glu Glu Ile Lys Lys Tyr Glu Asn Leu 
        915                 920                 925             


Gln Lys Glu Leu Glu Lys Asn Asp Phe Tyr Lys Ile Gln Glu Asn Ile 
    930                 935                 940                 


His Arg Lys Tyr Asn Gln Lys Pro Asn Leu Ile Leu Arg Thr Glu Asn 
945                 950                 955                 960 


Lys Lys Asp Phe Asn Asn Tyr Lys Lys Ala Ile Glu Asn Ile Gln Asn 
                965                 970                 975     


Tyr Thr Gln Leu Lys Asn Lys Ile Glu Phe Asn Asp Leu Asn Leu Leu 
            980                 985                 990         


Gln Ser Leu Leu Phe Arg Ile Leu  His Arg Leu Ala Gly  Tyr Thr Ser 
        995                 1000                 1005             


Leu Trp  Glu Arg Asp Leu Gln  Phe Lys Leu Lys Gly  Glu Phe Pro 
    1010                 1015                 1020             


Glu Asp  Lys Tyr Ile Asp Glu  Ile Phe Asn Ser Asp  Gly Asn Asn 
    1025                 1030                 1035             


Asn Gln  Lys Tyr Lys Asn Gly  Gly Ile Ala Asp Lys  Tyr Ala Asp 
    1040                 1045                 1050             


Phe Leu  Ile Glu Lys Glu Glu  Glu Lys Ser Gly Glu  Ile Leu Lys 
    1055                 1060                 1065             


Lys Asn  Gln Arg Asn Lys Arg  Lys Lys Lys Ile Lys  Glu Asp Leu 
    1070                 1075                 1080             


Glu Ile  Arg Asn Tyr Ile Ala  His Phe Asn Tyr Phe  Pro Asp Ala 
    1085                 1090                 1095             


Thr Lys  Ser Ile Leu Glu Leu  Leu Glu Glu Leu Arg  Glu Leu Leu 
    1100                 1105                 1110             


Lys Tyr  Asp Arg Lys Leu Lys  Asn Ala Val Met Lys  Ser Val Lys 
    1115                 1120                 1125             


Asp Ile  Phe Lys Glu Tyr Gly  Phe Ile Val Glu Phe  Gly Ile Ser 
    1130                 1135                 1140             


His Glu  Ser Asp Ser Lys Lys  Ile Lys Val Cys Asp  Val Lys Ser 
    1145                 1150                 1155             


Glu Glu  Ile Lys His Leu Lys  Asn Asn Gly Leu Val  Thr Thr Arg 
    1160                 1165                 1170             


Asn Ser  Lys Asp Leu Cys Asn  Leu Val Lys Val Met  Leu Glu Tyr 
    1175                 1180                 1185             


Lys Lys  Ser 
    1190     


<210>  1097
<211>  1307
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1097

Met Lys Phe Thr Lys Val Asp Asp Ser Arg Thr Phe Arg Lys Asn Glu 
1               5                   10                  15      


Asn Asn Ser Gly Lys Ile Ile Lys Tyr Glu Gly Thr Ile Asp Glu Asn 
            20                  25                  30          


Ser Lys Tyr Val Glu Cys Ser Leu Glu Ala Lys Lys Asn Ala Tyr Ile 
        35                  40                  45              


Ala Asn Asn Leu Asn Lys Leu Leu Tyr Thr Ser Leu Ala Lys Lys Val 
    50                  55                  60                  


Glu Lys Thr Lys Asn Lys Asp Thr Lys Ala Asn Gln Met Leu Ser Ile 
65                  70                  75                  80  


Leu Lys Gln Ile Ser Val Asp Lys Asn Asp Lys Val Tyr Met Ser Asp 
                85                  90                  95      


Lys Asn Ile Ala Lys Ile Lys Ser Ile Tyr Asp Ser Val Ile Lys Ser 
            100                 105                 110         


Gly Lys Asn Leu Asp Cys Val Leu Ala Thr Phe Ser Lys Asp Asp Asn 
        115                 120                 125             


His Phe Gly Phe Ile Lys Asn Ala Ile Arg Asp Ile Cys Leu Asn Ser 
    130                 135                 140                 


Asn Asn Gln Thr Phe Gln Leu Lys Phe Asp Leu Ser Ala Glu Lys Leu 
145                 150                 155                 160 


Ile Asn Tyr Cys Tyr His Glu Glu Asp Thr Asp Val Ser Phe Tyr Tyr 
                165                 170                 175     


Lys Arg Lys Asn Gln Ile Glu Lys Lys Ala Asn Ile Ile Ile Asp Ser 
            180                 185                 190         


Ile Ala Tyr Asn Ser Ile Ala Val Arg Asp Ile Glu Lys Ile Phe Thr 
        195                 200                 205             


Glu Tyr Glu Asn Gln Asn Lys Asp Ile Lys Lys Asp Asp Ser Ile Glu 
    210                 215                 220                 


Lys Lys Ile Glu Lys Leu Leu Asp Ile Tyr Gln Ile Glu Lys Leu Ile 
225                 230                 235                 240 


Ala Ser Ile Lys Val Phe Phe Cys Asp Glu Lys Ala Leu Glu Asp Lys 
                245                 250                 255     


Glu Ser Asn Asn Ile Glu Asn Ile Ala Phe Leu Asp Ile Val Glu Asp 
            260                 265                 270         


His Ile Lys Tyr Asn Lys Ile Asp Asp Asn Tyr Lys Phe Arg Asp Lys 
        275                 280                 285             


Glu Asn Gln Phe Leu Asp Lys Lys Ser Gly Lys Val Lys Glu Lys Gln 
    290                 295                 300                 


Gln Leu Ile Arg Asn Lys Ile Ile Lys Lys Ile Phe Phe Thr Phe Gln 
305                 310                 315                 320 


Leu Asn Ser Ile Glu Ile Lys Gln Ala Trp Glu Lys Gln Lys Asp Gln 
                325                 330                 335     


His Glu Lys Thr Pro Leu Lys Tyr Ile Asp Asp Phe Val Lys Glu Tyr 
            340                 345                 350         


Leu Asp Lys His Phe Pro Ile Lys Asn Thr Lys Ser Arg Trp Ser Leu 
        355                 360                 365             


Asp Asp Leu Asn Lys Asp Lys Ile Phe Tyr Phe Cys Lys Cys Arg Tyr 
    370                 375                 380                 


Tyr Asn Lys Arg Thr Thr Ser Asn Ile Leu Lys Ser Arg Ile Lys Glu 
385                 390                 395                 400 


Ser Asp Ser Gly Gln Ile Phe Asn Ser Ile Asp Leu Glu Lys Asn His 
                405                 410                 415     


Ile Asp Asn Val Leu Gln Arg Lys Met Ser Ala Ile Ile Ala Tyr Ala 
            420                 425                 430         


Gly Asn Asp Tyr Asn Ser Lys Ile Val Glu Lys Leu Lys Lys Ile Tyr 
        435                 440                 445             


Lys Thr Asp Leu Glu Glu Gln Leu Ser Glu Ile Glu Val Lys Met Gln 
    450                 455                 460                 


Ser Ile Pro Ala Phe Ile Asp Glu Lys Gly Ser Glu Val Lys Ile Phe 
465                 470                 475                 480 


Asp Gly Lys Ile Asn Lys Tyr Lys Lys Asp Leu Asp Ser Lys Met Lys 
                485                 490                 495     


Val Met Glu Val Tyr Lys Asn Tyr Leu Lys Asp Asp Phe Val Ser Thr 
            500                 505                 510         


Gly Ile Lys Glu Asn Cys Lys Ile Val Lys Glu Glu Val Asn Leu Leu 
        515                 520                 525             


Glu Lys Lys Lys Asp Glu Ile Leu Ser Tyr Leu Glu Asp Ser Leu Ser 
    530                 535                 540                 


Lys Ile Asp Asn Glu Ile Ser Arg Lys Asp Ile Leu Gly Lys Asn Lys 
545                 550                 555                 560 


Thr Lys Leu Glu Glu Tyr Ile Ala Arg Leu Ser Glu Thr Asn Gln Ile 
                565                 570                 575     


Leu Phe Lys Gln Ser Ile Phe Glu Arg Arg Cys Ile Phe Ala Ile Arg 
            580                 585                 590         


Asn Thr Asn Ile His Phe Lys Arg Lys Leu Asp Thr Thr Ile Leu Glu 
        595                 600                 605             


Lys Ser Asp Asn Gln Glu Ile Lys Thr Asn Ile Leu Ser Glu Tyr Arg 
    610                 615                 620                 


Asn Lys Ile Ser Glu Leu Pro Ser Ile Ala Ile Ser Asn Ala Tyr Asp 
625                 630                 635                 640 


Asn Asn Val Ile Asn Thr Trp Gly Leu Glu Lys Thr Val Glu Phe Leu 
                645                 650                 655     


Ser Asp Asn Asn Leu Phe Tyr Val Ala Lys Glu Asn Lys Cys Pro Ser 
            660                 665                 670         


Phe Lys Arg Leu Val Asn Tyr Cys Lys Asp Met Asn Val Ala Ile Asp 
        675                 680                 685             


Lys Gly Lys Leu Lys Arg Asp Lys Val Glu Leu Pro Asn Leu Ile Ile 
    690                 695                 700                 


Glu Ile Ala Asn Leu His Lys Gln Asn Ser Ser Thr Ile Gln Tyr Lys 
705                 710                 715                 720 


Asn Tyr Met Met Lys Leu Leu Tyr Tyr Gly Lys Ser Glu Glu Leu Ala 
                725                 730                 735     


Lys Gly Leu Lys Ser Tyr Ile Asn Lys Ser Leu Lys Asp Tyr Lys Leu 
            740                 745                 750         


Glu Glu Gln Leu Lys Lys Phe Asp Phe Gln Asn Ile Ser Thr Asn Gln 
        755                 760                 765             


Ala Met Tyr Asp Lys Phe Leu Gln Ile Asp Asp Leu Asp Thr Leu Lys 
    770                 775                 780                 


Glu Tyr Val Gln Arg Val Lys Ser Tyr Leu Gln Leu Glu Glu Gly Lys 
785                 790                 795                 800 


Glu Phe Lys Ala Leu Asp Lys Leu Glu Ile Glu Val Val Ser Asn Lys 
                805                 810                 815     


Phe Leu Asn Asp Tyr Lys Lys Gln Ile Glu Cys Ile Leu Lys Ser Glu 
            820                 825                 830         


Asp Val Glu Asn Lys Lys Leu Asn Lys Asp Asp Ile Leu Asp Val Phe 
        835                 840                 845             


Ser Glu Gly Leu Glu Asn Ala Ser Tyr Asn Ile Ser Ile Pro Lys Phe 
    850                 855                 860                 


Asn Glu Leu Thr Glu Asn Ser Asn Glu Ile Met Phe Ile Ser Leu Leu 
865                 870                 875                 880 


Lys Tyr Leu Ser Lys Arg Arg Leu Ser Glu Leu Leu Gln Asn Leu Leu 
                885                 890                 895     


Ser Tyr Lys Val His Arg Asn Lys Phe Asn Met Asn Gly Lys Ile Tyr 
            900                 905                 910         


Gly Ala Phe Asp Leu Asp Ile Leu Ile Glu Met Thr Gln Ile Tyr Met 
        915                 920                 925             


Ile Thr Tyr Asn Asn Thr Ser Ile Asn Asp Val Asp Glu Glu Lys Tyr 
    930                 935                 940                 


Val Asn Met Leu Asn Gly Phe Leu Glu Lys Asn Phe Lys Glu Tyr Asn 
945                 950                 955                 960 


Lys Ile Phe Ser Gln Asn Gly Glu Asn Glu Arg Lys Ile Leu Tyr Ala 
                965                 970                 975     


Asp Glu Glu Asn Pro Val Lys Phe Tyr Gln Ile Ile Glu Ala Asp Arg 
            980                 985                 990         


Glu Asn Ile Leu Asp Lys Tyr Lys  Asp Tyr Tyr Glu Asn  His Lys Ile 
        995                 1000                 1005             


Ser Tyr  Glu Glu Val Thr Arg  Phe Asn Glu Leu Glu  Lys Glu Val 
    1010                 1015                 1020             


Ala Ile  Ala Leu Asp Lys Lys  Asn Asn Ile Lys Ile  Glu Val Ile 
    1025                 1030                 1035             


Lys Ala  Ser Lys Asn Leu Tyr  Lys Val Ser Lys Ser  Ile Lys Lys 
    1040                 1045                 1050             


Leu Glu  Glu Arg Lys Ala Gly  Tyr Arg Glu Lys Asn  Glu Ile Glu 
    1055                 1060                 1065             


Glu Lys  Arg Leu Ser Lys Glu  Lys Asn Ile Lys Thr  Ile Lys Thr 
    1070                 1075                 1080             


Ile Lys  Asn Ser Ile Lys Leu  Leu Lys Lys Glu Tyr  Thr Asp Glu 
    1085                 1090                 1095             


Tyr Lys  Lys Ile Leu Glu Tyr  Asn Arg Leu Lys Asn  Arg Ile Leu 
    1100                 1105                 1110             


Phe Thr  Asp Val Arg Lys Met  Asn Ser Leu Leu Cys  Asp Leu Tyr 
    1115                 1120                 1125             


Gly Lys  Phe Asn Gly Leu Ile  Ala Ile Tyr Glu Lys  Asn Leu Tyr 
    1130                 1135                 1140             


Tyr Ser  Leu Ser Asp Glu Asp  Lys Arg Lys Val Asp  Asp Ala Val 
    1145                 1150                 1155             


Asn Arg  Asp Asn Met Phe Asp  Phe Ile Lys Lys Lys  Lys Asp Ser 
    1160                 1165                 1170             


Trp His  Lys Glu Asn Ile Glu  Ser Asn Asn Gly Lys  Asn Lys Glu 
    1175                 1180                 1185             


Asn Cys  Pro Tyr Gly Asn Ile  Met Leu Asp Glu Asn  Asp Tyr Ser 
    1190                 1195                 1200             


Asn Arg  Asn Lys Phe Ala His  Phe Asp Tyr Leu Thr  Gly Asn Asp 
    1205                 1210                 1215             


Lys Asp  Asn Asp Asn Phe Ala  Cys Gln Leu Asn Lys  Leu Arg Lys 
    1220                 1225                 1230             


Leu Leu  Arg Gly Asp Arg Lys  Leu Lys Asn Ile Val  Thr Lys Val 
    1235                 1240                 1245             


Val Ile  Ala Thr Phe Glu Lys  His Gly Leu Gln Ile  Asp Met Lys 
    1250                 1255                 1260             


Phe Asn  Asn Asn His Glu Ile  Tyr Arg Met Gln Val  Glu Arg Met 
    1265                 1270                 1275             


Glu Met  Gln Asp Glu Tyr Leu  Asn His Phe Glu Val  Val Lys Ile 
    1280                 1285                 1290             


Glu Asp  Cys Phe Leu Glu Met  Ile Lys Glu Val Leu  Lys Ile 
    1295                 1300                 1305         


<210>  1098
<211>  1364
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1098

Met Pro Arg Gly Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg 
1               5                   10                  15      


Pro Gly Ile Ser Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg 
            20                  25                  30          


Gln Ser Leu Leu Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu 
        35                  40                  45              


Glu Ser Lys Asp Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala 
    50                  55                  60                  


Gln Lys Leu Tyr Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp 
65                  70                  75                  80  


Glu Asn Arg Gln Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala 
                85                  90                  95      


Val Ile Asn Asn Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys 
            100                 105                 110         


Glu Gln Arg Val Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys 
        115                 120                 125             


Lys Ser Ile Lys Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu 
    130                 135                 140                 


Ile Val Lys Phe Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys 
145                 150                 155                 160 


Gly Thr Gly Ser Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu 
                165                 170                 175     


Val Leu Arg Lys Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu 
            180                 185                 190         


Asn Gly Tyr Arg Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser 
        195                 200                 205             


Ala Ile Cys Leu Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu 
    210                 215                 220                 


Lys Ala Phe Phe Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr 
225                 230                 235                 240 


Val Glu Gln Ile Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys 
                245                 250                 255     


Val Val Glu Lys Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp 
            260                 265                 270         


His Arg Lys Lys Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala 
        275                 280                 285             


Ala Asp Glu Lys Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu 
    290                 295                 300                 


Ile Gly Leu Tyr Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn 
305                 310                 315                 320 


Arg Phe Ser Asp Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile 
                325                 330                 335     


Glu Glu Ile Leu Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys 
            340                 345                 350         


Lys Lys Glu Asn Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys 
        355                 360                 365             


Tyr Arg Ala Ala Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val 
    370                 375                 380                 


Leu Gly Glu Ile Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr 
385                 390                 395                 400 


Trp Ile Glu Tyr Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser 
                405                 410                 415     


Arg Asn Lys Asp Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His 
            420                 425                 430         


Ile Trp Lys Glu Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met 
        435                 440                 445             


Gly Lys Gly Val Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu 
    450                 455                 460                 


Glu Gly Glu Pro Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn 
465                 470                 475                 480 


Gly Val Ser Gly Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu 
                485                 490                 495     


Glu Arg Glu Met Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala 
            500                 505                 510         


Arg Ala Val Thr Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp 
        515                 520                 525             


Val Leu Leu Met Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys 
    530                 535                 540                 


Glu Glu Arg Gln Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr 
545                 550                 555                 560 


Leu Tyr Ala Asp Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln 
                565                 570                 575     


Ser Arg Phe Arg Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly 
            580                 585                 590         


Glu Asp Leu Tyr Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn 
        595                 600                 605             


Ile Thr Phe His Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys 
    610                 615                 620                 


His Asp Leu Ala Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr 
625                 630                 635                 640 


Glu Leu Phe Arg Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr 
                645                 650                 655     


Asp Val Glu Val Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg 
            660                 665                 670         


Lys Tyr Arg Ala Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg 
        675                 680                 685             


Pro Glu Leu Pro Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu 
    690                 695                 700                 


Arg Arg Leu Met Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp 
705                 710                 715                 720 


Ser Ala Leu Phe Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu 
                725                 730                 735     


Gln Glu Gln Lys Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg 
            740                 745                 750         


Ala Ile Glu Lys Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys 
        755                 760                 765             


Ala Trp Glu Ser Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg 
    770                 775                 780                 


Ser Phe Gly Ala Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln 
785                 790                 795                 800 


Asn Ser Asp Ile Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala 
                805                 810                 815     


Asn Asn Lys Lys Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn 
            820                 825                 830         


Cys Ile Arg Glu Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu 
        835                 840                 845             


Leu Arg Thr Pro Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe 
    850                 855                 860                 


Cys Arg Ala Asp Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys 
865                 870                 875                 880 


Lys Thr Phe Asn Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala 
                885                 890                 895     


His Phe Ile Asn Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg 
            900                 905                 910         


Asn Tyr Leu Gln Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu 
        915                 920                 925             


Gly Asp Cys Val Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg 
    930                 935                 940                 


Asn Thr Leu Glu Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr 
945                 950                 955                 960 


Thr Asn Val Met Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu 
                965                 970                 975     


Tyr Leu Ser Gly Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp 
            980                 985                 990         


Ile Glu Lys Ala Leu Tyr Ser Phe  Cys Lys Gln Lys Phe  Lys Val Asp 
        995                 1000                 1005             


Gly Lys  Glu Tyr Met Ala Gly  Ile Tyr Tyr Asp Gly  Glu Asn Leu 
    1010                 1015                 1020             


Ile Pro  Asn Arg Asn Ile Ile  Arg Ala Asn Met Tyr  Gly Asn Thr 
    1025                 1030                 1035             


Ser Cys  Leu Lys Pro Cys Met  Asp Arg Ile Thr Leu  Lys Glu Ile 
    1040                 1045                 1050             


Arg Thr  Met Tyr Ala Asp Gln  Asn Lys Leu Asp Leu  Val Leu Lys 
    1055                 1060                 1065             


Glu Gly  Val Cys His Thr Glu  Glu Glu Gln Lys Ala  Tyr Arg Glu 
    1070                 1075                 1080             


Tyr Gln  Asn Glu Lys Asn Arg  Ile Glu Leu Phe Asp  Val Cys Thr 
    1085                 1090                 1095             


Tyr Thr  Gln Ile Leu Asn Asp  Met Gln Ala Arg Leu  Ile Gly Trp 
    1100                 1105                 1110             


Ser Tyr  Met Arg Glu Arg Asp  Leu Met Tyr Tyr Gln  Leu Gly Tyr 
    1115                 1120                 1125             


Tyr Tyr  Thr Lys Leu Phe Trp  Thr Asp Ser Ile Ser  Glu Glu Asp 
    1130                 1135                 1140             


Ala Arg  Arg Arg Leu Val Gly  Asn Leu Val Asn Val  Glu Asp Gly 
    1145                 1150                 1155             


Ala Ile  Leu Tyr Gln Ile Leu  Ala Phe Asn Ser Tyr  Asn Leu Pro 
    1160                 1165                 1170             


Ile Ile  Ala Asn Lys Asn Asn  Thr Val Thr Leu Leu  Lys Asp Glu 
    1175                 1180                 1185             


Gly Ser  Ile Gly Gly Lys Ala  Ile Thr Ala Phe Phe  Lys Asn Tyr 
    1190                 1195                 1200             


Glu Asn  Ala Glu Met Ile Tyr  Glu Glu Ala Leu Asp  Leu Phe Glu 
    1205                 1210                 1215             


Asn Met  Asp Glu His Ala Ala  Ile Ile Asn Thr Arg  Asn Tyr Ile 
    1220                 1225                 1230             


Glu His  Phe Lys Tyr Phe Ile  Lys Ser Asp Arg Ser  Met Met Asp 
    1235                 1240                 1245             


Leu Tyr  Ser Glu Ile Tyr Asp  Arg Phe Phe Arg His  Asp His Asn 
    1250                 1255                 1260             


Arg Lys  Lys Asn Val Pro Asp  Ser Leu Lys Asn Val  Leu Ala Asp 
    1265                 1270                 1275             


Asn Phe  Met Ile Val Asp Ile  Asp Met Glu Leu Gly  Ser Lys Lys 
    1280                 1285                 1290             


Val Gly  Glu Lys Lys Lys Gly  Phe Arg Glu His Lys  Ala Ala Arg 
    1295                 1300                 1305             


Ile Glu  Phe Thr Asp Ser Gly  Ile Arg Ser Thr Asp  Met Thr Tyr 
    1310                 1315                 1320             


Thr Ile  Lys Pro Asp Ile Lys  Asp Asn Lys Lys Asp  Lys Lys Val 
    1325                 1330                 1335             


Leu Val  Pro Ala Arg Ser Glu  Val Phe Leu Lys Gln  Phe Arg Lys 
    1340                 1345                 1350             


Ile Leu  Glu Tyr Arg Ile Gln  Asp Lys Ile Gln 
    1355                 1360                 


<210>  1099
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1099

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Gly Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn Tyr Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Gly Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Gly Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Ser Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  1100
<211>  1315
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1100

Met Ile Ile Ile Lys Lys Phe Gly Arg Ser Val Ile Thr Gln Asp Lys 
1               5                   10                  15      


Asn Thr Asp Asn Lys Arg Glu Arg Glu Leu Asp Thr Ser Ala Arg Ala 
            20                  25                  30          


Lys Ala Lys Ser Gln Asn Ser Gln Val Phe Pro Phe Leu Asn Lys Lys 
        35                  40                  45              


Glu Asp Phe Ile Asn Leu Trp Ile Ser Glu Phe Asp Lys Leu Ile Tyr 
    50                  55                  60                  


Lys Pro Lys Gly Asp Asp Lys Pro Thr Lys Glu Met Tyr Thr Leu Arg 
65                  70                  75                  80  


Glu Ala Ala Gly Lys Gly Phe Leu Asn Tyr Trp Asn Gln Met Pro Met 
                85                  90                  95      


Val Ser Lys Lys Asp Gly Ala Phe Ser Asp Met Trp Met Ser Lys Val 
            100                 105                 110         


His Pro Tyr Gly Arg Gly Ile Thr Glu Phe Ser Pro Pro Leu Gln Leu 
        115                 120                 125             


Glu Lys Leu Ile Asp Gln Gly Leu Leu Ser Ala Met Gly Gly Ser Glu 
    130                 135                 140                 


Pro Leu Lys Asn Cys His Trp Asn Arg Val Thr Ser Asn Val Phe Lys 
145                 150                 155                 160 


Gly Leu Lys Val Gln Leu Asp Ile Leu Glu Ala Gln Ala Lys Asn Thr 
                165                 170                 175     


Phe Val Ile Lys Asn Lys Thr Asn Ser Lys Arg Asn Arg Pro Ala Ser 
            180                 185                 190         


Gln Asn Ile Lys Glu Phe Leu Leu Thr Asp Glu Thr Ala Phe Ile Asn 
        195                 200                 205             


Leu Trp Ile Ser Glu Phe Asp Lys Leu Ile Leu Lys Pro Gln Gly His 
    210                 215                 220                 


Asn Lys Pro Thr Glu Lys Met Tyr Asn Leu Arg Gln Gln Ala Gly Val 
225                 230                 235                 240 


Ala Phe Leu Asn Tyr Trp Lys Lys Lys Pro Leu Ile Pro Trp Ala Asn 
                245                 250                 255     


Ser Glu Ser Phe Pro Asp Lys Trp Met Leu Lys Val His Pro Tyr Gly 
            260                 265                 270         


Asp Lys Thr Ser Asn Asn Arg Ser Glu Thr Leu Ile Lys Ser Lys Trp 
        275                 280                 285             


Gly Ser Val Met Arg Ala Lys Glu Cys Leu Ser Asp Asp Gln Trp Glu 
    290                 295                 300                 


Gln Val Ala Phe Asn Val Tyr Ser His Leu Tyr Gly Asn Gln Lys Thr 
305                 310                 315                 320 


Leu Asn Gly Lys Asn Lys Glu Ile Gly Leu Ile Ala Ala Arg Ala Asn 
                325                 330                 335     


Ser Ile Lys Gln Asn Val Pro Ser Tyr Thr Leu Asp Lys Asp Asn Asn 
            340                 345                 350         


Phe Leu Ser Asp Lys Lys Asp Lys Leu Arg Tyr Ile Ala Ala Leu Arg 
        355                 360                 365             


Gly Glu Gly Ile Lys Trp Glu Glu Val Lys Asp Arg Tyr Lys Trp Lys 
    370                 375                 380                 


Glu Leu Thr Gln Leu Ile Asn Ile Glu Glu Ile Asp Ser Thr Asp Ile 
385                 390                 395                 400 


Ala Lys Arg Lys Gln His Leu Ala Glu Cys Phe Tyr Thr His His Gly 
                405                 410                 415     


Arg Ile Phe Gly Asp Ile Gln Asn Ser Lys Ile Glu Asp Lys Asp Cys 
            420                 425                 430         


Phe Leu Tyr His Ser Leu Val Lys Glu Ile Leu Phe Glu Cys Ile Glu 
        435                 440                 445             


Lys Lys Gln Asp Phe Leu Asn Asp Thr Glu Val His Gln Arg Leu Ile 
    450                 455                 460                 


Tyr Lys Glu Asn Asn Arg Ile Met Ala Thr Ala Val Ser Ile Gly Lys 
465                 470                 475                 480 


Leu Ile His Tyr Gln Gly Gly Ile Glu Ala Ile Gly Asn Lys Glu Asp 
                485                 490                 495     


Leu Val Asn Ser Lys Phe Leu Thr Asp Ala Gly Leu Thr Glu Ile Lys 
            500                 505                 510         


Gln Asn Glu Ser Phe Val Arg Gln Trp Leu Glu Leu Ile Ala Ile Ala 
        515                 520                 525             


Asn Thr Thr Leu Ser Gln Leu Val Asp Pro Asp Gly Lys His Glu Asp 
    530                 535                 540                 


Ile Phe Ala Ala Thr Ser Phe Asp Asp Ala Leu Lys Gly Leu Asn Asn 
545                 550                 555                 560 


Ile Ser Asp Phe Asp Ser Lys Phe Lys Leu Leu Phe Gly Glu Asn His 
                565                 570                 575     


Arg Leu Tyr Asp Asp Asp Thr Glu Arg Gln Lys Leu Leu Arg Ile Ile 
            580                 585                 590         


Tyr Asp Thr Ile Ser Ala Leu Arg Asn Ala Ser Phe His Phe Lys Asn 
        595                 600                 605             


Ile Gln Gly Phe Asn Lys Ala Leu Glu Asp Asn Leu Ser Thr Lys Gly 
    610                 615                 620                 


Arg Arg Gln Lys Gly Val Val Asp Lys Ile Ile Glu Tyr Thr Lys Val 
625                 630                 635                 640 


His Gln Gln Lys Gln His Glu Leu Leu Ile Ala Asp Leu Lys Ala Ala 
                645                 650                 655     


Asn Val Glu Asp Tyr Leu Ser Gln Leu Gln Leu Asp Tyr Leu Phe Glu 
            660                 665                 670         


Val Val Cys Lys Gly Glu Arg Glu Leu Leu Asp Met Pro Lys Phe Ser 
        675                 680                 685             


Lys Leu Leu Leu Arg Ala Gly Glu Ile Gly Glu Lys Ile Ile Ser Pro 
    690                 695                 700                 


Val Asn Ala Thr Ala Met Glu His Pro Ala Tyr Gln Cys Cys Phe Ile 
705                 710                 715                 720 


Ser Leu Lys Met Leu Tyr Asp Gln Asp Phe Val Asn Trp Leu Lys Lys 
                725                 730                 735     


Gln Ser Asn Lys Asn Ile Ala Ser Trp Met Asp Ser Ala Lys Thr Arg 
            740                 745                 750         


Ala Thr Asn Ala Ala Lys Lys Ile Phe Arg Asn Gly Thr Asn Ile Ser 
        755                 760                 765             


Ser Lys Met Ala Arg Leu Arg Asn Ile Val Glu Asp Glu Thr Leu Val 
    770                 775                 780                 


Glu Tyr Phe Ser Phe Ile Thr Ala Glu Thr Ala Asn Glu Phe Gln Val 
785                 790                 795                 800 


Gln Gln Gln Lys Asn Arg Tyr Gln Ser Asn Ser Ala Ser Ala Lys Glu 
                805                 810                 815     


Gln Ser Asn Phe Val Glu Gln Phe Lys Gln Asp Phe Leu Ile Tyr Ala 
            820                 825                 830         


Phe Lys Gly Tyr Ile Gly Asp Ile Lys Phe Gly Lys Leu Asp Gln Gly 
        835                 840                 845             


Glu Lys Leu Leu Lys Cys Asn Ala Lys Gly Ser Leu Leu Pro Glu Asn 
    850                 855                 860                 


Asn Arg Ser Asp Thr Gly Ala Glu Asp Ile Glu Arg Pro Trp Leu Tyr 
865                 870                 875                 880 


Leu Val Leu His Leu Val Pro Ile Glu Val Val Asn Arg Ile Thr Leu 
                885                 890                 895     


Gln Ile Lys Lys His Ser Val Leu Thr Asn Ser Thr Leu Asp Asp Thr 
            900                 905                 910         


Arg Ala Ala Tyr Thr Asp Ile His Gln Ala Phe Ser Leu Tyr Leu Gly 
        915                 920                 925             


Val His Gly Ala Ile Leu Gly Leu Gln Ser Leu Ser Asn Glu Pro Glu 
    930                 935                 940                 


Leu Gln Val Phe Phe Glu Lys Glu Ser Asp Phe Asn Asn Leu Phe Thr 
945                 950                 955                 960 


Asp Asn Gly Glu Gly Leu Val Pro Val Lys Gly Leu Arg Asp Ile Leu 
                965                 970                 975     


Arg Phe Gly Asn Leu Glu Gln Leu Lys Lys Met Phe Ser Asp Lys Lys 
            980                 985                 990         


Val Ala Ser Asp Asp Ile Thr Asn  Leu Lys Glu Tyr Leu  Glu Ala Thr 
        995                 1000                 1005             


Gly Gly  Lys Ser Lys Ile Ala  Arg Ala Gln Glu Lys  Arg Ile Glu 
    1010                 1015                 1020             


Leu His  Lys Thr Leu Thr Glu  Leu Pro Lys Arg Leu  Thr Lys Pro 
    1025                 1030                 1035             


Arg Val  Lys Gln Thr Gly Ile  Asp Thr Tyr Glu Lys  Asn Asn Asn 
    1040                 1045                 1050             


Ile Ser  Ile Ser Gly Ser Ile  Ser Glu Tyr Arg Lys  Asp Leu Lys 
    1055                 1060                 1065             


Cys Ile  Val Ser Tyr Arg Glu  Leu Lys Asn Lys Ile  Tyr Leu Tyr 
    1070                 1075                 1080             


Asn Val  Lys Gln Ala His Gln  Leu Ile Met Ala Thr  Gln Ala Arg 
    1085                 1090                 1095             


Leu Leu  Gly Tyr Ser Gln Ile  Arg Glu Arg Asp Leu  Tyr Phe Val 
    1100                 1105                 1110             


Leu Leu  Thr Gln Leu Met Leu  Arg Gly Val Thr Leu  Glu Lys Glu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Asp Lys Asp  Lys Leu Asn Ala Leu  Asp Thr Asp 
    1130                 1135                 1140             


Thr Val  Leu Asp Glu Glu Glu  Lys Lys Lys Leu Glu  Lys Gln Ile 
    1145                 1150                 1155             


Lys Pro  Glu Arg Ser Leu Lys  Asp Leu Val Glu Lys  Gly Leu Ile 
    1160                 1165                 1170             


Phe Leu  Ala Leu Asp Gln Leu  Ser Ser Ser Asp Lys  Asp Leu Lys 
    1175                 1180                 1185             


Ala Ile  His Ser Glu Ile Glu  Asp Met Phe Val Gly  Val Ser Pro 
    1190                 1195                 1200             


Asp Ser  Asp Asn Arg Asn Leu  Arg Asn Arg Leu Ala  His Phe Lys 
    1205                 1210                 1215             


Asp Leu  Gly Asn Lys Asn Leu  Ile Asn Ile Thr Ser  Gln Ile Asn 
    1220                 1225                 1230             


Glu Val  Arg Lys Met Met Ser  Tyr Asp Arg Lys Leu  Lys Asn Ala 
    1235                 1240                 1245             


Val Ser  Lys Ser Met Ile Asp  Leu Phe Glu Arg Tyr  Asn Leu Ile 
    1250                 1255                 1260             


Leu Ser  Phe Lys Val Gln Ser  His Lys Leu Gln Leu  Lys Asn Leu 
    1265                 1270                 1275             


Lys Ser  Lys Gln Ile Thr His  Leu Asn Asn Lys Gly  Ile Thr Glu 
    1280                 1285                 1290             


Asn Leu  Leu Ser Asp Asp Tyr  Val Ser Val Ile Lys  Arg Leu Leu 
    1295                 1300                 1305             


Leu Thr  Glu Gln Asn Pro Glu  
    1310                 1315 


<210>  1101
<211>  1101
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1101

Met Arg Ile Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Ile Tyr Ser Glu 
            20                  25                  30          


Gln Ala Val Ser Asn Glu Thr Asn Asn Ile Leu Pro Val Lys Lys Met 
        35                  40                  45              


Asp Ser Phe Asn Leu Ser Ile Leu Asn Lys Thr Ile Ile Lys Phe Glu 
    50                  55                  60                  


Thr Val Lys Lys Gln Lys Leu Asn Leu Asp Gln Tyr Lys Ile Val Glu 
65                  70                  75                  80  


Lys Ile Phe Lys Tyr Pro Lys Gln Glu Leu Pro Lys Gln Ile Asn Ala 
                85                  90                  95      


Glu Glu Ile Leu Gln Phe Leu Asn His Lys Phe Gln Glu Pro Val Lys 
            100                 105                 110         


Tyr Trp Lys Asn Gly Lys Glu Glu Ser Phe Asn Leu Thr Leu Leu Ile 
        115                 120                 125             


Val Glu Ala Val Lys Thr Gln Glu Lys Arg Lys Leu Gln Pro Tyr Tyr 
    130                 135                 140                 


Asp Trp Lys Thr Trp Tyr Ile Gln Thr Lys Ser Asp Leu Leu Lys Lys 
145                 150                 155                 160 


Ser Ile Glu Asn Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg 
                165                 170                 175     


Lys Lys Ala Leu Leu Ala Trp Glu Thr Glu Phe Thr Thr Ser Gly Ser 
            180                 185                 190         


Ile Asp Leu Thr His Phe His Lys Val Tyr Met Thr Asp Val Leu Cys 
        195                 200                 205             


Thr Ala Leu Gln Lys Val Glu Pro Ser Ala Asp Glu Arg Gly Lys Met 
    210                 215                 220                 


Asn Ser Asn Ala Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Asn His 
225                 230                 235                 240 


Gln Pro Ala Ile Phe Gly Thr Arg Glu Ala Pro Asn Glu Val Asn Arg 
                245                 250                 255     


Ala Asp Asn Gln Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu 
            260                 265                 270         


Glu His Tyr Phe Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Ala Asp 
        275                 280                 285             


Asp Ile Ser His Tyr Leu Lys Ala Gln Thr Leu Lys Thr Thr Ile Glu 
    290                 295                 300                 


Lys Gln Leu Val Asn Ala Ile Arg Ala Asn Ile Ile Gln Gln Gly Lys 
305                 310                 315                 320 


Thr Asn His His Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile 
                325                 330                 335     


Arg Ile Lys Thr Asn Glu Ala Phe Val Leu Asn Leu Ile Gly Thr Cys 
            340                 345                 350         


Ala Phe Ala Ala Asn Asn Ile Arg Asn Met Val Asp Lys Glu Gln Ile 
        355                 360                 365             


Ser Asp Ile Leu Gly Lys Arg Glu Phe Ile Asp Ser Leu Thr Lys Ser 
    370                 375                 380                 


Arg Ile Ser Ser Gln Leu Tyr Ser Phe Phe Phe Gly Glu Asn Leu Ser 
385                 390                 395                 400 


Thr Asn Lys Ala Glu Lys Glu Thr Gln Leu Trp Gly Ile Arg Gly Ala 
                405                 410                 415     


Val Gln Gln Ile Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu 
            420                 425                 430         


Thr Thr Ile Phe Asn Ile Cys Lys Phe Glu Asn Pro Thr Asp Ala Asp 
        435                 440                 445             


Pro Lys Gln Gln Thr Asn Tyr Val Asp Ser Ile Tyr Lys Thr Leu Phe 
    450                 455                 460                 


Ile Lys Glu Leu Glu Lys Ile Pro Glu Ala Phe Ala Gln Gln Leu Lys 
465                 470                 475                 480 


Thr Gly Gly Ala Leu Ser Tyr Tyr Thr Val Glu Asn Leu Lys Thr Leu 
                485                 490                 495     


Leu Thr Thr Phe Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala 
            500                 505                 510         


Pro Gly Phe Lys Lys Val Leu Asn Gly Gly Ile Asn Tyr Gln Asn Ala 
        515                 520                 525             


Lys Gln Asp Glu Ser Phe Tyr Glu Leu Met Leu Glu Arg Tyr Leu Arg 
    530                 535                 540                 


Lys Glu Asn Phe Ala Glu Glu Ala Tyr Asn Ala Arg Tyr Phe Leu Leu 
545                 550                 555                 560 


Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Lys Phe Thr Ala Asp Arg 
                565                 570                 575     


Lys Ala Phe Ala Asp Ser Val Gly Phe Val Gln Leu Gln Asn Arg Lys 
            580                 585                 590         


Gln Ala Glu Asn Ser Lys Arg Pro Lys Ala Phe Ala Phe Glu Ala Val 
        595                 600                 605             


Arg Pro Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala Tyr Val 
    610                 615                 620                 


Gln Ser Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys Ala Thr 
625                 630                 635                 640 


Asp Glu Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val Phe Ile 
                645                 650                 655     


Lys Gly Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe Val Gln 
            660                 665                 670         


Val Pro Gln Pro Gln Leu Thr Thr Thr Asp Ser Asn Gln Gln Lys Ala 
        675                 680                 685             


Asp Lys Leu Asn Gln Leu Glu Ala Ser Ile Thr Ala Asp Cys Lys Leu 
    690                 695                 700                 


Thr Ala Gln Tyr Ala Lys Thr Asp Asp Ala Thr His Ile Ala Phe Tyr 
705                 710                 715                 720 


Val Phe Cys Lys Leu Leu Asp Ala Gly His Leu Ser Asn Leu Arg Asn 
                725                 730                 735     


Glu Leu Ile Lys Phe Arg Gly Ser Val Lys Asp Phe Asp Phe His His 
            740                 745                 750         


Leu Leu Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val Val Pro 
        755                 760                 765             


Thr Asp Tyr Arg Asp Leu Tyr Ser Ser Gly Ala Asp Cys Leu Ala Arg 
    770                 775                 780                 


Leu Arg Pro Phe Ile Glu Gln Gly Ala Asp Ile Lys Asn Trp Ser Asp 
785                 790                 795                 800 


Leu Tyr Val Gln Thr Asp Lys Gln Thr Pro Val Ile His Ala Gly Ile 
                805                 810                 815     


Glu Leu Ser Val Lys Tyr Gly Thr Thr Ala Leu Leu Glu Gln Leu Ile 
            820                 825                 830         


Thr Cys Asn Pro Lys Phe Arg Val Met Glu Asp Asn Phe Thr Lys Trp 
        835                 840                 845             


Ser Ala Gln Lys Lys Glu Ile Glu Glu Lys Val Asn Lys His Thr Asn 
    850                 855                 860                 


Leu His Gln Gln Trp Val Glu Ala Lys Glu Lys Asp Asp Arg Glu Arg 
865                 870                 875                 880 


Val Lys Ser Lys Lys Asn Phe Val Arg Glu Tyr Val Lys Lys Asn Tyr 
                885                 890                 895     


Val Asp Tyr Ile Asn Asn Cys Ile Glu Ile Asn Asn Tyr Asn Trp Leu 
            900                 905                 910         


Asp Asn Lys Leu His Phe Val His Leu Asn His Leu His His Leu Thr 
        915                 920                 925             


Ile Asp Ile Leu Gly Arg Met Ala Gly Phe Val Ala Leu Trp Glu Arg 
    930                 935                 940                 


Asp Phe Gln Tyr Ile Thr Lys Tyr Thr Ala Ala Lys Glu Gly Thr Asp 
945                 950                 955                 960 


Ala Leu Ser Phe Asp Gly Gly Leu Pro Arg Leu Lys Asp Lys Gln Glu 
                965                 970                 975     


Tyr Tyr Asn Lys Leu Phe Leu Ser Asp Lys Tyr Thr Lys Val Arg Asn 
            980                 985                 990         


His Ile Ala His Phe Asn Tyr Leu  Thr Lys Asp Ala Ala  Asp Phe Ala 
        995                 1000                 1005             


Leu Leu  Asp Leu Ile Asn Glu  Leu Arg Glu Leu Leu  His Tyr Gly 
    1010                 1015                 1020             


Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ala Phe Ile  Asp Leu Phe 
    1025                 1030                 1035             


Glu Lys  His Gly Met Ile Leu  Lys Leu Lys Leu Asn  Thr Asp His 
    1040                 1045                 1050             


Gln Leu  Val Val Glu Ser Ile  Glu Pro Lys Lys Ile  Tyr His Leu 
    1055                 1060                 1065             


Gly Ser  Thr Ala Lys Asp Lys  Pro Glu Tyr Gln Tyr  Thr Thr Asn 
    1070                 1075                 1080             


Gln Val  Met Thr Val Tyr Cys  Asn Met Cys Arg Ser  Leu Leu Glu 
    1085                 1090                 1095             


Met Lys  Lys 
    1100     


<210>  1102
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1102

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Gly Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  1103
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1103

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Pro Gly Thr Asp Thr 
            20                  25                  30          


Ile Asp Leu Lys Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Lys Val Phe Asn Gln Ile Gln Val Gly Asn Lys Pro Lys Lys 
    50                  55                  60                  


Trp Lys Lys Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Glu Tyr Val Glu Ser Ser Gln Arg Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Glu Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Ser Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Met Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Tyr Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ser Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Lys Asp Arg Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Lys Glu Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Gln Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Phe 
            660                 665                 670         


Ile Arg Lys Asn Phe Pro Glu Asp Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Ala 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Asp Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Val Tyr Cys  Lys Ile Lys Gly Lys  Asp Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asn  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asn  Ser Glu Lys Lys Glu  Ala Tyr Gln Lys Ile  Glu Val Asn 
    1100                 1105                 1110             


Gly Asp  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Ala Val  Tyr Ala Pro Asp Glu  Lys Gly Asp 
    1130                 1135                 1140             


Ile Leu  Lys Glu Gln Cys Thr  Lys Gly Gly Ala Gly  Gly Lys Ile 
    1145                 1150                 1155             


Ser Ala  Phe Asn Arg Tyr Ser  Glu Tyr Leu Gly Leu  Asp Lys Leu 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Asp  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Val Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Lys Gln 
    1250                 1255                 1260             


Thr Thr  Ser Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Ser Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Lys  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Val Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Gly Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Pro Asn 
    1370                 1375                 1380         


<210>  1104
<211>  1183
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1104

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Pro Val Ser  Tyr Thr His 
    1160                 1165                 1170             


Leu Arg  Ala His Glu Thr Glu  Leu His Leu 
    1175                 1180             


<210>  1105
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1105

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Val Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Gly Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Lys Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Lys Ile Leu Lys Tyr Thr Glu Ser Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Glu Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Leu Lys Glu Leu Lys Glu Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn Tyr Thr Met Gln Gln Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Lys Lys Asp Glu Lys Phe Asn Asp Glu Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Lys Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Lys  Glu Leu Cys 
    1130                 1135                 1140             


Glu Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Glu  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  1106
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1106

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  1107
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1107

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Pro Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  1108
<211>  1284
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1108

Met Ile Ile Gly Gly Ile Asn Met Lys Leu Thr Arg Arg Arg Ile Ser 
1               5                   10                  15      


Gln Glu Arg Lys Asn Gln Lys Leu Thr Ala Ala Phe Tyr Arg Asp Met 
            20                  25                  30          


Asp His Gly Leu Leu Tyr Val Asp Ser Glu Asp Glu Asp Arg Thr Glu 
        35                  40                  45              


Tyr Val Val Ser Ser Met Asp Phe Glu Arg Ser Trp Arg Gly Arg Ile 
    50                  55                  60                  


Leu Lys Asn Gly Glu Asp Asn Lys Asn Pro Phe Tyr Glu Phe Val Lys 
65                  70                  75                  80  


Gly Leu Val Gly Ser Asn Glu Ile Ile Cys Lys Pro Ile Thr Asn Asp 
                85                  90                  95      


Asn Asn Thr Asp Ile Asn Glu Lys Ile Lys Lys Tyr Ile Thr Glu Phe 
            100                 105                 110         


Gly Arg Asn Leu Lys Ala Pro Gly Ser Glu Val Thr Leu Glu Lys Leu 
        115                 120                 125             


Ile Leu Asn Ile Gln Ser Gly Thr Ser Glu Asn Glu Val Arg Pro Glu 
    130                 135                 140                 


Leu Glu Lys Ile Lys Asp Met Ile Lys Lys Asp Ile Glu Lys Arg Lys 
145                 150                 155                 160 


Asp Glu Leu Ile Lys Ser Ile Thr Asn Asn His Ile Pro Phe Met Leu 
                165                 170                 175     


Asp Glu Asp Lys Leu Val Pro Ser Thr Lys Lys Met Lys Trp Leu Tyr 
            180                 185                 190         


Lys Phe Leu Asn Gly Pro Asp Lys Ser Leu Asn Leu Gln Met Phe Asp 
        195                 200                 205             


Glu Tyr Trp Ile Lys Tyr Gly Tyr Lys Asn Leu Glu Glu Lys Ile Ile 
    210                 215                 220                 


Lys Glu Ile Asn Ser Leu Pro Glu Lys Asn Ala Arg Ser Ile Ser Arg 
225                 230                 235                 240 


Ala Val Ser Lys Thr Val Arg Glu Tyr Asn Arg Asn Phe Arg Ile Asn 
                245                 250                 255     


Tyr Met Val Pro Glu Asn Glu Asn Ala Glu Ala Asp Ser Asp Tyr Glu 
            260                 265                 270         


Gly Phe Leu Leu Phe Leu Lys Ala Val Glu Gln His Phe Lys Lys Tyr 
        275                 280                 285             


Tyr Pro Val Lys Ser Lys Asp Ser Ser Glu Val Arg Asp Lys Asn Leu 
    290                 295                 300                 


Cys Glu Glu Lys Asn Tyr Lys Phe Tyr Cys Ser Tyr Asn Phe Val Lys 
305                 310                 315                 320 


Asn Glu Val Lys Arg Ser Ile Ile Asn Gln Leu Val Ser Gly Leu Ile 
                325                 330                 335     


Gln Gln Gly Lys Leu Leu His Tyr Phe Tyr Lys Asp Gly Ile Trp Gln 
            340                 345                 350         


Gln Asp Phe Leu Asn Ser Tyr Gly Leu Ser Tyr Ile Gln Val Glu Glu 
        355                 360                 365             


Ser Phe Lys Lys Ser Leu Met Thr Ser Leu Ser Trp Gly Ile Asn Arg 
    370                 375                 380                 


Leu Thr Ser Phe Phe Ile Asp Val Gly Thr Asp Glu Asn Glu Glu Lys 
385                 390                 395                 400 


Thr Val Gln Asn Lys Lys Gln Lys Asn Asn Arg Lys Ile Asp Asp Ile 
                405                 410                 415     


Leu Ser Asp Lys Ser Asn Leu Arg Ala Ile Phe Asn Asp Leu Arg Ser 
            420                 425                 430         


Asn Thr Glu Leu Gln Lys His Phe Lys Glu Lys Leu Ala Phe Cys Tyr 
        435                 440                 445             


Pro Ile Phe Ile Lys Val Lys Lys Glu Lys Met Phe Asp Asp Ile Glu 
    450                 455                 460                 


Lys Leu Ile Lys Leu Val Glu Glu Ala Arg Glu Ser Val Ala Tyr Leu 
465                 470                 475                 480 


Arg His Arg Cys Phe His Tyr Lys Asp Val Thr Ile Thr Glu Met Leu 
                485                 490                 495     


Lys Ala Leu Asn Asn Asn Thr Glu Thr Asp Lys Thr Glu Asp Ile Asp 
            500                 505                 510         


Tyr Ser Val Ala Ala Glu Tyr Phe Leu Arg Asp Ile Asn Asn Leu Tyr 
        515                 520                 525             


Asp Ala Phe Arg Glu Gln Ile Arg Ser Ser Gly Ile Ala Asp Tyr Tyr 
    530                 535                 540                 


Pro Ala Asp Ile Ile Ser Gly Cys Phe Lys Lys Cys Gly Leu Gln Phe 
545                 550                 555                 560 


Val Leu Tyr Ser Pro Gln Asn Ser Leu Met Pro Ser Phe Lys Asn Ile 
                565                 570                 575     


Tyr Lys Arg Gly Ser Asn Leu Tyr Lys Ala Tyr Gln Glu Glu Lys Glu 
            580                 585                 590         


Gln Lys Asp Lys Glu Tyr Lys Arg His Asn Thr Asn Ile Val Gln Glu 
        595                 600                 605             


Glu Ser Lys Glu Leu Ser Trp Tyr Ile Glu Val Ser Asp Thr Glu Gln 
    610                 615                 620                 


Gly Lys Thr Ala Tyr Arg Asn Leu Leu Gln Leu Ile Tyr Tyr His Ala 
625                 630                 635                 640 


Phe Leu Pro Glu Val Arg Glu Asn Glu Ser Leu Ile Thr Val Tyr Phe 
                645                 650                 655     


Ala Lys Thr Lys Glu Trp Asn Arg Lys Val Ala Glu Thr Lys Ala Lys 
            660                 665                 670         


Lys Lys Asn Ala Gly Lys Thr Tyr Lys Asp Lys Pro Ile Arg Ala Tyr 
        675                 680                 685             


Arg Tyr Glu Ala Ile Pro Asp Tyr Val Gly Glu Arg Leu Asp Asp Tyr 
    690                 695                 700                 


Phe Lys Ile Leu Gln Arg Glu Gln Met Ala Lys Ala Lys Asp Val Asn 
705                 710                 715                 720 


Glu Gly Asn Ala Glu Asn Asn Asn Tyr Ile Gln Phe Ile Arg Asp Val 
                725                 730                 735     


Val Val Trp Ala Phe Gly Ala Tyr Leu Glu Glu Arg Leu Glu Lys Tyr 
            740                 745                 750         


Lys Lys Asp Leu Gln Ser Ser His Ser Gln Lys Asp Lys Lys Asp Val 
        755                 760                 765             


Asn Asp Ala Leu Lys Glu Leu Phe Pro Asp Asp Lys Asp Lys Arg Gln 
    770                 775                 780                 


Phe Phe Met Lys Cys Lys Phe Thr Asp Val Leu Ile Asn Asp Val Gly 
785                 790                 795                 800 


Glu Asn Asn Gln Ile Thr Glu Met Glu Asp Leu Glu Thr Ser Lys Glu 
                805                 810                 815     


Gln Gln Asn Arg Glu Ile Lys Arg Lys Asp Leu Leu Cys Phe Tyr Leu 
            820                 825                 830         


Phe Leu Arg Leu Leu Asp Glu Arg Glu Ile Ser Gly Leu Lys His Gln 
        835                 840                 845             


Phe Val Arg Tyr Arg Cys Ser Leu Lys Glu Arg Arg Leu Pro Asp Asn 
    850                 855                 860                 


Arg Lys Asp Val Asp Glu Glu Ile Val Leu Leu Glu Glu Leu Glu Glu 
865                 870                 875                 880 


Leu Met Glu Leu Val Ser Tyr Thr Met Pro Ser Val Pro Glu Leu Ser 
                885                 890                 895     


Gly Lys Ala Glu Ser Gly Leu Asp Leu Val Ile Ser Lys Tyr Phe Lys 
            900                 905                 910         


Asp Phe Phe Glu Lys Ser Ala Leu Lys Asn Gln Asp Ile Met Lys Leu 
        915                 920                 925             


Tyr Tyr Gln Ser Asp Asn Lys Thr Pro Val Phe Arg Lys Tyr Met Ala 
    930                 935                 940                 


Leu Leu Met Arg Ser Ala Pro Leu Gln Leu Tyr Lys Asp Met Phe Arg 
945                 950                 955                 960 


Asn Tyr Tyr Ile Ile Thr Glu Lys Glu Cys Gln Glu Tyr Ile Lys Thr 
                965                 970                 975     


Ser Gln Asp Ile Asp Ala Phe Gln Cys Lys Leu Asn Glu Leu His Lys 
            980                 985                 990         


Glu Leu Glu His Val Arg Leu Lys  Thr Val Glu Asp Lys  Lys Gly Lys 
        995                 1000                 1005             


Ile Phe  Tyr Tyr Leu Ala Gly  Ser Asp Ala Glu Arg  Val Lys Glu 
    1010                 1015                 1020             


Tyr Glu  Asp Thr Leu Ser Lys  Val Val Arg Tyr Lys  Arg Leu Gln 
    1025                 1030                 1035             


His Lys  Leu Thr Phe Glu Ser  Leu Tyr Thr Ile Phe  Lys Ile His 
    1040                 1045                 1050             


Val Asp  Ile Ala Ala Arg Met  Val Gly Tyr Thr Glu  Asp Trp Glu 
    1055                 1060                 1065             


Arg Asp  Met Leu Phe Leu Phe  Lys Ser Leu Glu Tyr  Asn Glu Lys 
    1070                 1075                 1080             


Leu Asn  Glu Gly Val Val Glu  Lys Ile Phe Asn Asn  Lys Asp Glu 
    1085                 1090                 1095             


Lys Gly  His Ile Val Lys Lys  Leu Lys Asp Asn Leu  Asn Ser Glu 
    1100                 1105                 1110             


Asp Lys  Glu Lys Ile Glu Ile  Leu Cys Trp His Lys  Glu Ile Thr 
    1115                 1120                 1125             


Asp Lys  Asn Phe Val Glu Ile  Ile Trp Ile Arg Asn  Pro Ile Ala 
    1130                 1135                 1140             


His Leu  Asn His Phe Met Gln  Thr Val Lys Asn Pro  Lys Arg Ser 
    1145                 1150                 1155             


Leu Glu  Lys Met Ile Asn Ala  Leu Cys Val Leu Leu  Ser Tyr Asp 
    1160                 1165                 1170             


Arg Lys  Arg Gln Asn Ser Val  Thr Lys Thr Ile Asn  Asp Leu Leu 
    1175                 1180                 1185             


Leu Asn  Glu Tyr His Val Lys  Ile Lys Trp Lys Arg  Trp Val Asp 
    1190                 1195                 1200             


Lys Asn  Cys Asn Ile Tyr Tyr  Tyr Ile Asp Glu Gln  Asn Ile Glu 
    1205                 1210                 1215             


Asn Glu  Pro Ile Leu His Ile  Lys His Leu His Met  Gly Glu Lys 
    1220                 1225                 1230             


Cys His  Val Asn Arg Asn Ala  Asp Met Phe Asp Arg  Gln Lys Glu 
    1235                 1240                 1245             


Trp Leu  Arg Asn Gly Ile Thr  Glu Glu Val Tyr Asp  Lys Ser Met 
    1250                 1255                 1260             


Leu Gly  Cys Ile Cys Arg Leu  Phe Lys Phe Asp Tyr  Asn Asp Leu 
    1265                 1270                 1275             


Tyr Gly  Ala Asn Arg Gln 
    1280                 


<210>  1109
<211>  1216
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1109

Met Lys Gly Val Pro Asn Met Lys Ile Thr Lys Arg Lys Trp Glu Asp 
1               5                   10                  15      


Val Pro Pro Leu Phe Phe His Arg Asp Lys Asp Ser Gly Arg Leu Ile 
            20                  25                  30          


Arg Gln Asp Asp Arg Glu His Asp Tyr Thr Asp Glu Leu Phe Arg Lys 
        35                  40                  45              


Thr Thr Val Asp Ser Ile Phe Ile Arg Ser Leu Gln Asn Arg Leu Leu 
    50                  55                  60                  


Arg Ser Gln Asp Lys Glu Gly Asn Lys Ile Gly Arg Asn Glu Ile Thr 
65                  70                  75                  80  


Glu Leu Val Glu Asn Leu Cys Lys Gly Ala Glu Ile Gln Lys Ser Ile 
                85                  90                  95      


Asp Glu Ile Lys Asp Ser Lys Ser Asn Val Lys Ala Leu Cys Asp Lys 
            100                 105                 110         


Thr Leu Thr Asp Tyr Gly Lys Ser Phe Ala Ala Glu Glu Gly Arg Thr 
        115                 120                 125             


Thr Leu Tyr Glu Ala Ile Leu Asn Leu Ala Lys Gly Asn Ala Ile Gln 
    130                 135                 140                 


Lys Ala Met Ala Glu Ala Glu Leu Lys Gln Ile His Glu Ala Leu Lys 
145                 150                 155                 160 


Lys Glu Lys Glu Asp Arg Ile Asn Arg Val Gln Asn Ser Ile Lys Asn 
                165                 170                 175     


Asn Lys Ile Pro Leu Lys Val Asn Glu Asp Gly Thr Ile Ser Ala Asn 
            180                 185                 190         


Asn Asp Arg Ala Ser Trp Leu Leu Glu Leu Leu Lys Pro Val Ala Ser 
        195                 200                 205             


Glu His Asp Lys Gly Asp Arg Tyr Pro Val Leu Thr Glu Met Glu Gly 
    210                 215                 220                 


Ile Val Ser Phe Asp Lys Leu Cys Glu Glu Val Arg Asn Lys Ile His 
225                 230                 235                 240 


Gly Arg Lys Gly Arg Thr Arg Ser Ile Ala Met Ser Val Asp Glu Ala 
                245                 250                 255     


Val Lys Glu Tyr Leu Lys Glu Leu Trp Lys Lys His Ala Asp Arg His 
            260                 265                 270         


Arg Asp Met Arg Tyr Tyr Phe Gln Ala Val Lys Glu Tyr Phe Lys Glu 
        275                 280                 285             


Asn Phe Pro Ile Arg Thr Lys Gln Lys Gly Ala Gly Ile Arg Gln Ser 
    290                 295                 300                 


Leu Leu Lys Glu Asp Thr Val Val Ala Arg Leu Leu Asp Pro Lys His 
305                 310                 315                 320 


Met Ala Lys Ala Val Arg Arg Lys Leu Ile Asn Gln Ser Thr Gln Met 
                325                 330                 335     


His Ile Leu Tyr Gly Lys Leu Tyr Glu Tyr Cys Cys Arg Glu Asp Arg 
            340                 345                 350         


Asn Leu Pro Val Asn Ser Glu Thr Leu Gln Leu Ile Gln Val Leu Glu 
        355                 360                 365             


Ala Val Lys Lys Gln Leu Met Thr Ala Val Leu Trp Ser Val Ser Arg 
    370                 375                 380                 


Leu Cys Tyr Phe Tyr Glu Phe Tyr Ser Gly Asp Ile Leu Leu Ala Glu 
385                 390                 395                 400 


Glu Tyr Arg Arg Asp Phe Leu Asn Gln Lys Asn Asp His Lys Asp Ile 
                405                 410                 415     


Gln Ala Cys Lys Glu Lys Leu Gln Asp Phe Phe Pro Leu Ala Glu Leu 
            420                 425                 430         


Gln Glu Lys Ile Arg Glu Cys Ala Asp Lys Asp Ile Asn Asn Ile Lys 
        435                 440                 445             


Asp Lys Ile Thr Asn Asp Val Leu Ala Cys Asn Asn Leu Leu Glu Glu 
    450                 455                 460                 


Cys Val Phe Cys Ile Ser Lys Leu Arg Asn Asn Ile Phe His Tyr Lys 
465                 470                 475                 480 


Asn Leu Ser Phe Thr Gln Ala Leu Lys His Ile Ala Asn Glu Ile Lys 
                485                 490                 495     


Glu Glu Asp Ile Pro Ile Ile Leu Arg Leu Tyr Lys Gln Asp Cys Glu 
            500                 505                 510         


Asn Val Asn Lys Ala Phe Ala Asn Arg Ile Ser Ser Met Asn Leu Pro 
        515                 520                 525             


Leu Tyr Tyr Ser Thr Glu Phe Leu Leu Arg Ile Phe Lys Lys Gln Gly 
    530                 535                 540                 


Ala Glu Leu Ser Leu Tyr Ser Thr Lys Asn Gln Met Thr Pro Ser Phe 
545                 550                 555                 560 


Lys Arg Val Tyr Glu Arg Gly Lys Asn Leu Arg Leu Glu Tyr Glu Arg 
                565                 570                 575     


Glu Pro Met Arg Ser Asn Ile Ala Asn Glu Tyr Asp Lys Asp Pro Gln 
            580                 585                 590         


Ser Asp Tyr Trp Met Arg Trp Phe Ser Gln Phe Ala Thr Gly Thr Val 
        595                 600                 605             


Asp Thr Asn Ala Gly Ile Lys Gly Glu Met Glu Asp Tyr Pro His Ala 
    610                 615                 620                 


Ser Val Asn Leu Gly Ile Glu Ile Glu Ala Gly Thr Asn Ile Asp Ala 
625                 630                 635                 640 


Gln Arg Ala Met Arg Asn Leu Leu Gln Leu Ile Tyr Lys His His Phe 
                645                 650                 655     


Leu Pro Glu Val Gln Lys Asp Glu Thr Val Val Thr Asp Val Ile Pro 
            660                 665                 670         


Lys Val Leu Glu Arg Asn Arg Lys Leu Ser Glu Val Arg Asn Arg Ser 
        675                 680                 685             


Asp Lys Thr Tyr Gly Tyr Lys Glu Ile Glu Glu Leu Cys Lys Lys Asn 
    690                 695                 700                 


Lys Gly Lys Lys Asp Ser Leu Ser Glu Leu Met Lys Asp Leu Gln Arg 
705                 710                 715                 720 


Lys Val Ser Glu Thr Glu Lys Glu Lys Arg Glu Leu Ala Arg Glu Lys 
                725                 730                 735     


Thr Asp Tyr Ala Gln Arg Phe Ile Leu Asp Ile Phe Ala Glu Ala Phe 
            740                 745                 750         


Cys Asn Phe Met Asp Glu Arg Tyr Glu Asp Glu Tyr Gln Glu Ile Met 
        755                 760                 765             


Ser Pro Ile Lys Asn Glu Glu Glu Ala Lys Lys Trp Thr Glu Met Phe 
    770                 775                 780                 


Thr Asp Lys Ala Asp Lys Asp Asn Lys Asp Lys Leu Leu Val Leu Lys 
785                 790                 795                 800 


Thr Ser Phe Asp Lys Asp Asn Val Glu Lys Tyr Leu Leu Val Leu Tyr 
                805                 810                 815     


Pro Leu Met Arg Leu Leu Asp Asp Lys Glu Leu Ser Glu Leu Gln Gln 
            820                 825                 830         


Gln Met Leu Arg Phe Arg Ala Ser Val Ser Gly Trp Gln Gly Gly Thr 
        835                 840                 845             


Asp Phe Ser Glu Asp Ile Ala Met Ala Glu Lys Ile Glu Glu Leu Ala 
    850                 855                 860                 


Glu Leu Val Lys Leu Thr Glu Pro Glu Ser Gln Tyr Ala Glu Glu Ala 
865                 870                 875                 880 


Trp Lys Asn Arg Ala Ile Gly Val Phe Glu Gln Phe Val Glu Gly Lys 
                885                 890                 895     


Met Ala Glu Tyr Gly Thr Phe Tyr Ile Gln Asn Asp Ser Leu Thr Gln 
            900                 905                 910         


Val Pro Arg Gly Asn Met Arg Lys Leu Leu Arg Ser Gly Val Ile Gly 
        915                 920                 925             


Val Tyr Asn Lys Val Leu Ala Ser Cys Lys Gln Ala Thr Lys Ala Asp 
    930                 935                 940                 


Tyr Gly Ala Tyr Ser Gly Asp His Trp Ser Ile Glu Asp Pro Asp Gly 
945                 950                 955                 960 


Asn Pro Ile Lys Ser Ala Glu Gln Ala Gln Ala Leu Leu Gln Arg Leu 
                965                 970                 975     


His Lys Lys Tyr Thr Glu Ser Pro Ser Gln Phe Ser Asp Asp Asp His 
            980                 985                 990         


Lys Leu Tyr Asp Lys Thr Leu Arg  Gln Leu Asp Ala Tyr  Asn Arg Ala 
        995                 1000                 1005             


Met Lys  Asn Leu Ser Phe Gly  Ser Leu Tyr Glu Ile  Cys Arg Ile 
    1010                 1015                 1020             


His Met  Glu Thr Leu Ser Arg  Trp Val Gly Phe Val  Gln Asp Trp 
    1025                 1030                 1035             


Glu Arg  Asp Met Tyr Phe Leu  Leu Leu Ala Trp Thr  Lys Gln Gly 
    1040                 1045                 1050             


Lys Leu  Leu Asn Val Thr Glu  Thr Asp Val Ile Glu  Ile Phe Glu 
    1055                 1060                 1065             


Lys Gly  Ser Val Ile Tyr Lys  Met Asn Lys Lys Leu  Lys Asn Gly 
    1070                 1075                 1080             


Asp Arg  Tyr Ala Phe Thr Ser  Ile Tyr Arg Asn Asn  Asn Asp Glu 
    1085                 1090                 1095             


Lys Leu  Glu Phe Leu Gln Ile  Arg Asn Phe Ile Ala  His Leu His 
    1100                 1105                 1110             


Leu Leu  Arg Lys Ser Glu Trp  Lys Gly Asp Lys Lys  Ala Gly Tyr 
    1115                 1120                 1125             


Ser Val  Ile Glu Asp Tyr Ile  Asn Lys Leu Arg Phe  Leu Leu Ser 
    1130                 1135                 1140             


Tyr Asp  Gln Lys Arg Met Asn  Ala Val Thr Lys Ala  Met Gln Gln 
    1145                 1150                 1155             


Ile Phe  Glu Lys His Lys Val  Ile Val Lys Phe Met  Val Glu Lys 
    1160                 1165                 1170             


Gly Gly  Met Leu Lys Val Lys  Asp Val Lys Pro Gly  Ile Ile Glu 
    1175                 1180                 1185             


His Leu  Lys Gln Thr Lys Arg  Ile Glu Ile Pro Cys  His Gly Glu 
    1190                 1195                 1200             


Arg Phe  Thr Asp Ser Leu Leu  Val Leu Met Lys Tyr  Gln 
    1205                 1210                 1215     


<210>  1110
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1110

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  1111
<211>  1358
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1111

Met Lys Ile Ser Lys Glu Gly His Lys Arg Met Ser Val Thr Leu Lys 
1               5                   10                  15      


Lys Glu Asn Met Gln Lys Asn Asp Ala Asp Lys Thr Lys Gly Gln Ile 
            20                  25                  30          


Leu Pro Leu Pro Glu Gly Glu Gly Leu Glu Lys Tyr Ile Gln Lys Arg 
        35                  40                  45              


Val Ala Asn Thr Gln Lys Leu Tyr Lys Val Leu Gly Pro Ser Ala Val 
    50                  55                  60                  


Ser Val Pro Asn Glu Lys Glu Lys Glu Thr Ile Asp Cys Phe Asn Asp 
65                  70                  75                  80  


Phe Ile Lys Asn Ile Ile Leu Lys Asn Val Asn Thr Gln Pro Ala Glu 
                85                  90                  95      


Lys Arg Asn Arg Asn Ala Val Glu Tyr Met Lys Thr Lys Gly Asn Val 
            100                 105                 110         


Asn Thr Val Phe Ile Asp Val Asp Arg Lys Cys Ile His Lys Leu Val 
        115                 120                 125             


Pro Leu His Leu Arg Gly Thr Leu Lys Lys Tyr Val Lys Ile Glu Lys 
    130                 135                 140                 


Asp Gly Gln Arg Ile Glu Val Tyr Ile Pro Asp Val Ile Glu Lys Leu 
145                 150                 155                 160 


Val Phe Ala Val Ala His Gly Thr Gln Phe Asp His Leu Ile Ala Glu 
                165                 170                 175     


Ile Glu Glu Glu Glu Leu Ile Val Cys Leu His Met Ile Phe Lys Asp 
            180                 185                 190         


Tyr Thr Lys Glu Asp Ile Ile Ala Asn Thr Ala Lys Ser Ile Glu Lys 
        195                 200                 205             


Gln Asp Val Lys Val Gln Val Leu Gly Thr Gly Glu Asp Ala Arg Leu 
    210                 215                 220                 


Gln Leu Ala Ser Ala Asp Asn Glu Lys Lys Lys Tyr Ile Phe Leu Phe 
225                 230                 235                 240 


Leu Lys Lys Phe Ala Cys Ala Val Ser Glu Lys Glu Arg Asn Asp Leu 
                245                 250                 255     


Leu Arg Glu Phe Arg Glu Leu Leu Val Leu Phe Tyr Cys Gly Thr Ala 
            260                 265                 270         


Ala Tyr Glu Glu Val Lys Glu Trp Lys Asn Gly Ile Pro Ile Trp Asp 
        275                 280                 285             


Phe Asp Phe Leu Ser Lys Met Val Ser Asp Ile Ser Trp Phe Phe Ser 
    290                 295                 300                 


Gln Glu Cys Ser Glu Lys Leu Met Glu Arg Glu Gln Leu Arg Arg Glu 
305                 310                 315                 320 


Lys Asp Lys Asp Lys Lys Arg Gln Asn Lys Ser Lys Ile Lys Asp Ile 
                325                 330                 335     


Asp Val Glu Val Lys Gly Ile Leu Ala Asn Leu Ile Thr Glu Arg Tyr 
            340                 345                 350         


Arg Glu Ser Ile Lys Leu Leu Gln Ser Leu Leu Gly Glu Glu Glu Tyr 
        355                 360                 365             


Lys Glu Lys Cys Phe Trp Leu Glu Tyr Ile Glu Asn Asp Ala Glu Lys 
    370                 375                 380                 


Ile Leu Cys Ser Lys Lys Ala Leu Thr Glu Asn Lys Leu Asp Thr Val 
385                 390                 395                 400 


Trp Leu Cys Asn Asn Thr Trp Arg Asn Phe Leu Ser Phe Leu Cys Ser 
                405                 410                 415     


Lys Ala Val Asp Met Gly Lys Ala Val Tyr His Phe Ala Met Pro Asp 
            420                 425                 430         


Leu Glu Gln Leu Glu Ser Gly Glu Pro Ile Lys Ala Gly Met Ile Lys 
        435                 440                 445             


Pro Gln Phe Gln Gln Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys 
    450                 455                 460                 


Ala Glu Glu Asn Leu Glu Arg Ser Phe Met Thr Ala Ile Ser Phe Ala 
465                 470                 475                 480 


Leu Asn Asn Phe Ser Ala Ala Val Cys Pro Pro Glu Thr Tyr Glu Lys 
                485                 490                 495     


Lys Asn Lys Glu Asp Val Leu Phe Met Gly Asp Lys Asp Leu Arg Glu 
            500                 505                 510         


Glu Met Tyr Pro Asn Ala Ser Trp His Ile Met Gln Tyr Phe Gly Gly 
        515                 520                 525             


Ile Ser Gln Trp Lys Asp Ser Cys Phe Glu Asp Ile Val Met Leu Glu 
    530                 535                 540                 


Asp Ala Asp Leu Asn Glu Glu Phe Val Leu Glu Val Lys Gly Ala Met 
545                 550                 555                 560 


Ser Leu Ile Arg Asn Ser Ala Phe His Tyr Ala Ala Ser Ala Ala Gln 
                565                 570                 575     


Gly Thr Leu Asp Lys Gly Ser Tyr Leu Val Glu Leu Phe Glu Arg Glu 
            580                 585                 590         


Arg Asp Asn Leu Gly Ser Lys Tyr Arg Lys Lys Tyr Val Ser Asn Asn 
        595                 600                 605             


Val Pro Met Phe Tyr Lys Val Glu Asp Ile Asp Arg Leu Met His Cys 
    610                 615                 620                 


Leu Tyr Gly Glu Gln Lys Val Leu Glu Ser Gln Ile Pro Ser Phe Arg 
625                 630                 635                 640 


Asn Val Ile Thr Arg Lys Ser Leu Pro Asp Ile Ile Val Lys Phe Val 
                645                 650                 655     


Lys Gly Lys Pro Tyr Gly Lys Ile Gln Lys Asn Val Glu Thr Ala Ser 
            660                 665                 670         


Lys Phe His Ser Ala Leu Tyr Phe Val Leu Lys Glu Ile Tyr Tyr Asn 
        675                 680                 685             


Gly Phe Leu Gln Glu Glu Asn Leu Met Glu Arg Phe Met Val Ser Phe 
    690                 695                 700                 


Asn Asn Glu Trp Asn Lys Val Lys Glu Ser Ser Gly Asn Lys Lys Lys 
705                 710                 715                 720 


Glu Ala Ala Met Lys Asp Phe Ser Arg Arg Ile Ser Glu Leu Gln Gln 
                725                 730                 735     


Asn Gly Lys Arg Leu Thr Phe Gly Glu Leu Cys Gln Ala Ile Met Thr 
            740                 745                 750         


Asp Tyr Asn Met Gln Asn Asn Gln Lys Lys Val Arg Leu Asn Lys Lys 
        755                 760                 765             


Asp Asn Leu Pro Asp Glu Lys Tyr Lys His Phe Lys Met Leu Leu Leu 
    770                 775                 780                 


Val Cys Leu Arg Glu Thr Phe Ile Asp Tyr Leu Lys Lys Asp Val Ala 
785                 790                 795                 800 


Gly Glu Lys Phe Asp Cys Ala Phe Leu Arg Glu Pro Gly Leu Lys Glu 
                805                 810                 815     


Asn Val Tyr Glu Asn Leu Thr Glu Glu Gln Phe Cys Lys Gly Trp Lys 
            820                 825                 830         


Ile Asp Arg Tyr Lys Asn Leu Ile Asn Glu Asn Gly Gln Tyr Asp Ser 
        835                 840                 845             


Trp Leu Ile Ser Trp Phe Ile Leu Ala His Phe Met Thr Pro Lys His 
    850                 855                 860                 


Leu Asn His Leu Cys Gly Glu Ile Lys Ser Tyr Leu Ser Tyr Val His 
865                 870                 875                 880 


Asn Ile Glu Arg Arg Arg Phe Asp Ala Met Arg Val Gln Val Glu Glu 
                885                 890                 895     


Asn Lys Glu Lys Arg Gln Lys Tyr Glu Gln Val Leu Glu Ile Leu Asn 
            900                 905                 910         


Leu Ala Ala Glu Tyr Cys Gly Gln Val Ser Asn Glu Arg Thr Asp Tyr 
        915                 920                 925             


Tyr Glu Ser Glu Glu Glu Tyr Ala Arg His Ile Ser Met Tyr Val Ala 
    930                 935                 940                 


Phe Glu Glu Lys Asn Ser Glu Arg Pro Leu Glu Glu Gln Leu Tyr Gly 
945                 950                 955                 960 


Phe Cys Asn Gln Lys Ala Asp Gly Gly Pro Ala Ser Arg Ile Gly Ile 
                965                 970                 975     


Phe Tyr Asp Gly Glu Asn Pro Ile Leu Asn Arg Asn Val Val Leu Thr 
            980                 985                 990         


Lys Leu Tyr Gly Ala Glu Arg Leu  Leu Ser Glu Cys Leu  Gln Lys Glu 
        995                 1000                 1005             


Arg Val  Thr Lys Ala Glu Ile  Glu Lys His Tyr Lys  His Thr Lys 
    1010                 1015                 1020             


Lys Leu  Glu Ala Val Phe Lys  Tyr Gly Thr Cys Lys  Asn Gln Glu 
    1025                 1030                 1035             


Gln Glu  Gln Glu Arg Arg Thr  Tyr Gln Gln Gln Lys  Asn Arg Ile 
    1040                 1045                 1050             


Glu Leu  Val Asp Ile Leu Lys  Tyr Ser Asp Leu Leu  Asn Asp Phe 
    1055                 1060                 1065             


Met Ser  Gln Leu Ile Ser Trp  Cys Tyr Leu Arg Glu  Arg Asp Arg 
    1070                 1075                 1080             


Met Tyr  Phe Gln Ile Gly Leu  His Tyr Ile Arg Leu  Tyr Tyr Gly 
    1085                 1090                 1095             


Glu Asn  Leu Val Glu Lys Asn  Ser Lys Phe Arg Val  Leu Gln Ser 
    1100                 1105                 1110             


Lys Glu  Ala Lys Ala Gly Glu  Lys Lys Gly Ile Asn  Leu Val Asp 
    1115                 1120                 1125             


Gly Ala  Val Leu Tyr Gln Ile  Ala Ala Ile Tyr Thr  Tyr Glu Tyr 
    1130                 1135                 1140             


Pro Val  Tyr Ala Leu Asp Glu  Ala Gly Asn Ala Ile  Val Ser Lys 
    1145                 1150                 1155             


Ala Ala  Lys Ile Gly Ser Thr  Thr Ala Asn Gly Ile  Asn Ala Phe 
    1160                 1165                 1170             


Trp Lys  Glu Tyr Cys Asn Glu  Asp Ala Ser Thr Tyr  Glu Val Gly 
    1175                 1180                 1185             


Leu Ser  Leu Phe Glu Asn Pro  Leu Glu Glu Lys Glu  Leu Ile Glu 
    1190                 1195                 1200             


Phe Arg  Asn Tyr Ile Asp His  Phe Lys Tyr Tyr Ser  Arg Arg Asp 
    1205                 1210                 1215             


Arg Ser  Ile Leu Asn Leu Tyr  Ser Gln Val Phe Ala  Asn Tyr Phe 
    1220                 1225                 1230             


Arg His  Asp Arg Lys Leu Lys  Lys Ser Val Thr Phe  Ile Leu Lys 
    1235                 1240                 1245             


Asn Ile  Leu Ala Arg His Phe  Ile Ile Ala Arg Thr  Val Leu Ala 
    1250                 1255                 1260             


Glu Val  Glu Val Glu Lys Lys  Asp Gly Arg Lys Asp  Lys Lys Asn 
    1265                 1270                 1275             


Pro Ile  Ile Arg Lys Tyr Ser  Gln Thr Glu Ile Arg  Ile Pro Thr 
    1280                 1285                 1290             


Glu Asn  Gly Leu Gln Ser Asp  Asp Thr Leu His Lys  Tyr Thr Lys 
    1295                 1300                 1305             


Glu Asp  Val Asp Asn Glu Tyr  Lys Lys Lys Met Asn  Asn Ser Lys 
    1310                 1315                 1320             


Gly Glu  Lys Gly Lys Ile Pro  Pro Lys Glu Gly Gly  Lys Tyr Ser 
    1325                 1330                 1335             


Ile Pro  Met Tyr Asp Glu Lys  Phe Ile Gln Arg Leu  Tyr Cys Ile 
    1340                 1345                 1350             


Leu Asn  Tyr Ala Lys 
    1355             


<210>  1112
<211>  1197
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1112

Met Gln Ile Ile Lys Pro Tyr Gly Arg Ser His Val Glu Glu Asn Arg 
1               5                   10                  15      


Ala Ala Gly Thr Arg Arg Val Leu Ser Leu Arg Leu Asp Pro Glu Lys 
            20                  25                  30          


Arg Met Asp Ile Val Glu Phe Ala Arg Ser His Glu Lys Leu Val Val 
        35                  40                  45              


Ala Gln Trp Ile Ser Thr Ile Asp Lys Ile Ala Ser Lys Pro Ala Gly 
    50                  55                  60                  


Glu Asn Gly Pro Thr Glu Glu Gln Arg Ala Phe Arg Gln Arg Leu Gly 
65                  70                  75                  80  


Asp Ala Ala Trp Thr Leu Leu Glu Ala Lys Gly Leu Leu Pro Gly Val 
                85                  90                  95      


Lys Gln Pro Glu Val Lys Gln Gln Leu Ala Lys Leu Trp Lys Val Lys 
            100                 105                 110         


Ile Ala Pro Tyr Gly Thr Ala Arg Tyr Arg Ala Glu Lys Asn Arg Lys 
        115                 120                 125             


Pro Pro Ser Val Arg Gly Arg Trp Tyr Asp His Phe Ser Glu Gly Val 
    130                 135                 140                 


Ala Asp Val Ala Asn Val Asp Ala Ala Glu Val Ala Lys Lys Ile His 
145                 150                 155                 160 


Glu His Leu Tyr Ile Ala Gly Tyr Arg Ile Gly Thr Gly Val Arg Asn 
                165                 170                 175     


Arg Arg Gln Gly His Ile Ala Ala Arg Ala Lys Ser Ile Ala Val Asn 
            180                 185                 190         


Val Leu Arg Thr Gly Leu Pro Ala Tyr Gly Gly Gly Val Gly Ala Gly 
        195                 200                 205             


Trp Met Ala Glu Asp Arg Asp Ser Tyr Ala Lys Ala Gly Asn Phe Val 
    210                 215                 220                 


Gln Glu Ile Arg Leu Ala Ala Glu Arg Arg Glu Arg Gly Glu Asp Lys 
225                 230                 235                 240 


Ala Gly Thr Leu Arg Val Thr Ser Ser Ile Ala Gly Lys Ala Leu Phe 
                245                 250                 255     


Glu His Tyr Ala Arg Leu Phe Lys Arg Ala Asp Gly Lys Ala Leu Ser 
            260                 265                 270         


Ile Arg Glu Ala Arg Glu Arg Thr Pro Gly Leu Phe Asn Leu His Met 
        275                 280                 285             


Ala Val Lys Asp Cys Tyr Ser Arg Ile Leu Lys Asn His Lys Lys Asp 
    290                 295                 300                 


Leu Lys Ala His Gly Asp Arg Arg Arg Lys Val Ser Ala Leu Leu Pro 
305                 310                 315                 320 


Ser Thr Met Asp Gly Leu Phe Ala Leu Leu Asp Ala Lys Arg Thr Asn 
                325                 330                 335     


Arg Asp Leu Asn Thr Leu Val Arg Leu Gly Lys Val Ile His Tyr Lys 
            340                 345                 350         


Ser Ser Gly Gly Val Glu Asp Trp Pro Ser Asp Pro Val His Asn Trp 
        355                 360                 365             


Pro Ala Asp Val Thr Arg Ser Phe Phe Trp Thr Ser Asp Gly Gln Ala 
    370                 375                 380                 


Ile Met Lys Arg Asn Glu Ala Phe Val Arg Val Trp Arg His Val Leu 
385                 390                 395                 400 


Ala Leu Ala Ser Arg Thr Leu Thr Asp Trp Ala Asp Pro Asp Gly Lys 
                405                 410                 415     


Ile Arg Ser Asp Ile Leu Leu Ser Gly Pro Ile Glu Arg Ala Thr Gly 
            420                 425                 430         


Asp Cys Phe Asp Asn Gly Asn Tyr Ala Arg Lys Leu Ala Leu Leu Phe 
        435                 440                 445             


Gly Ser Arg Ala Asp Ile Phe Gln Cys Ala Gly Asp Asp Ala Val Gln 
    450                 455                 460                 


Lys Asn Val Leu Arg His Ala Leu Glu Gly Ile Ala Gly Leu Arg His 
465                 470                 475                 480 


Ser Ser Phe His Phe Lys Gly Leu Gly Gly Phe Ala Asp Ala Leu Thr 
                485                 490                 495     


Arg Ser Gln Phe Ala Leu Asp Glu Asn Val Ile Gly Ala Val Arg Gln 
            500                 505                 510         


Leu Trp Gln Ala Asp Val Gly Gly Arg Ala Gly Gln Leu Leu Lys Thr 
        515                 520                 525             


Met Arg Ala Ala His Phe Glu Tyr Phe Leu Gly Glu Ser Gln Asn Arg 
    530                 535                 540                 


Lys Leu Leu Ala Val Leu Ser Asn Ala Glu Ser Ala Leu Ile Pro Leu 
545                 550                 555                 560 


Pro Arg Phe Ser Lys Met Leu Glu Arg Ala Gln Asn Ala Trp Arg Asp 
                565                 570                 575     


Gly Lys Asp Gly Leu Arg Leu Pro Lys Pro Ala Asn Arg Thr Asp Arg 
            580                 585                 590         


Glu Asn Pro Ala Arg Leu Cys Gln Tyr Ala Ala Leu Lys Leu Leu Tyr 
        595                 600                 605             


Glu Arg Ala Phe Arg Asn Trp Leu Tyr Glu Arg Ser Ala Glu Ser Leu 
    610                 615                 620                 


Asn Arg Phe Ile Asp Arg Ala Val Glu Arg Ala Thr Ala Ala Ala Arg 
625                 630                 635                 640 


Asp Leu Asn Ala Arg Asp Asp Glu Asp Arg Arg Asp Ile Ile Val Ala 
                645                 650                 655     


Lys Ala Ala Thr Leu Gly Arg Leu Ala Asp Gly Glu Thr Val Glu Thr 
            660                 665                 670         


Phe Phe Phe Lys Leu Ser Ala Gln Thr Ala Ser Glu Met Arg Val Gln 
        675                 680                 685             


Arg Gly Tyr Asp Ser Asp Ala Asp Arg Ala Arg Glu Gln Ala Gly Tyr 
    690                 695                 700                 


Ile Glu Asn Leu Lys Ser Asp Val Val Val Leu Ala Phe Gly Ala Tyr 
705                 710                 715                 720 


Leu Lys Glu Ala Ser Phe Asp Phe Leu Leu Lys Leu Ser Pro Asp Ala 
                725                 730                 735     


Pro Lys Pro Glu Lys Pro Leu Cys Ile Leu Asp Gly Met Arg Arg Asp 
            740                 745                 750         


Glu Gly Asp Arg Pro Ala Glu Asn Trp Gln Met Thr Leu Tyr Phe Leu 
        755                 760                 765             


Ile His Leu Val Pro Val Asp Glu Ile Gly Lys Leu Leu His Gln Met 
    770                 775                 780                 


Arg Lys Trp Glu Ser Leu Ala Ala Lys Pro Val Met Ala Asp Pro Asp 
785                 790                 795                 800 


Arg Arg Gln Leu Asp Lys Ser Thr Ile Ala Asp Asn Val Arg Lys Val 
                805                 810                 815     


Gln Ser Val Leu Glu Leu Tyr Leu Asp Met His Asp Ala Lys Phe Asp 
            820                 825                 830         


Gly Glu Ala Ala Leu Ile Gly Thr Gly Ala Phe Lys Lys Leu Tyr Glu 
        835                 840                 845             


Pro Glu Asp Leu Phe Asp Arg Ile Phe Pro Arg Gln Phe Gly Ala Asp 
    850                 855                 860                 


Asp Asp Arg Arg Ile Pro Arg Arg Gly Leu Arg Glu Ile Met Arg Phe 
865                 870                 875                 880 


Gly His Leu Gln Val Leu Arg Pro Val Phe Gln Lys His Pro Ile Gln 
                885                 890                 895     


Leu Ala Lys Val Glu Lys Phe Phe Ala Ala Glu Glu Arg Gln Asp Glu 
            900                 905                 910         


Gly Lys Ser Val Ile Ala Arg Gln Gln Glu Arg Arg Glu Ile Leu His 
        915                 920                 925             


Glu Lys Trp Ala Arg Asn Lys Lys Gly Phe Ser Ala Asp Asp Arg Gln 
    930                 935                 940                 


Ala Tyr Glu Glu Ala Leu Ala Ala Val Ile Arg Tyr Arg His Leu Ala 
945                 950                 955                 960 


Ala His Val Thr Leu Thr Asp His Val Arg Leu His Arg Leu Leu Met 
                965                 970                 975     


Ile Val Leu Gly Arg Leu Val Asp Tyr Ser Gly Leu Trp Glu Arg Asp 
            980                 985                 990         


Leu Tyr Phe Val Ala Leu Ala Leu  Ile Tyr Glu Val Gly  Cys Arg Pro 
        995                 1000                 1005             


Glu Asp  Val Phe Glu Lys Glu  Gly Leu Glu Phe Leu  Lys Asn Gly 
    1010                 1015                 1020             


Arg Ile  Val Gly Ala Leu Arg  Lys Leu Lys Gln Thr  Ser Ala Ala 
    1025                 1030                 1035             


His Ala  Val Val Asp Arg Leu  Ser Arg His Phe Gly  Ala Val His 
    1040                 1045                 1050             


Gly Lys  Glu Asn Arg Ala Val  Glu Ile Arg Asn Gly  Phe Ala His 
    1055                 1060                 1065             


Phe Asp  Met Leu Arg Ser Thr  Asn Arg Pro Val Asp  Leu Thr Ala 
    1070                 1075                 1080             


Cys Val  Asn Asp Ala Arg Asn  Leu Met Ala Tyr Asp  Arg Lys Leu 
    1085                 1090                 1095             


Lys Asn  Ala Val Ser Gln Ser  Ile Ala Glu Phe Leu  Ser Arg Glu 
    1100                 1105                 1110             


Gly Leu  Val Ile Ala Trp Ala  Ile Thr Pro Asp His  Arg Leu Gly 
    1115                 1120                 1125             


Thr Ala  Thr Leu Glu Thr Arg  Gln Ala Arg His Leu  Gly Gly Ser 
    1130                 1135                 1140             


Ser Ile  Leu Glu Asp Leu His  Gly Asn Gly Phe Val  Gln Met Val 
    1145                 1150                 1155             


Ala Ala  Leu Phe Asp Arg Cys  Thr Pro Arg Arg Pro  Ser Gly Gly 
    1160                 1165                 1170             


Glu Asn  Gln Arg Gly Gly Lys  Ser Ala Pro Gly Lys  Ser Arg Ala 
    1175                 1180                 1185             


Met Gln  Asn His Glu Ser His  Arg Pro 
    1190                 1195         


<210>  1113
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1113

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  1114
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1114

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  1115
<211>  1311
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1115

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Gln Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Lys Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Asp Ile Gln Arg Ile Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Lys Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Thr Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Ile Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Ile Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Gln Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Lys 
                405                 410                 415     


Arg Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Ile Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Ala Leu Glu Gly Glu Ser 
    450                 455                 460                 


Val Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Glu Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Ala Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Lys Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Lys Asp Asp Glu Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Ser Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Lys Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Ala Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Val Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Glu Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Asp 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Lys Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly 
    1310     


<210>  1116
<211>  1394
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1116

Met Arg Ile Leu Gln Ser Lys Gly Arg Ser Phe Thr Thr Phe Ser Ala 
1               5                   10                  15      


Glu Ser Ile Gly Met Thr Arg Gly Leu Glu Pro Asp Asp Thr Gln Ser 
            20                  25                  30          


Ala Ala Lys Trp Leu Asp Glu Gly Glu Lys Arg Ile Ala Pro Val Arg 
        35                  40                  45              


Ile Pro Val Phe Leu Lys Glu Asp Pro Asp Leu Ile Ile Arg Gln Val 
    50                  55                  60                  


Val Ser Val Leu Asp Lys Val Ile Arg Lys Thr Lys Ile Leu Arg Asp 
65                  70                  75                  80  


Leu Pro Leu Gln Thr Tyr Val Asp Arg Thr Leu Leu Ala Glu Glu Leu 
                85                  90                  95      


Trp Gln Arg Ile Thr Asp Arg Ile Arg Gln Ser His Asp Gly Glu Ile 
            100                 105                 110         


Thr Pro Ala Asp Leu Asp Ala Tyr Lys Ser Arg Trp Ser Trp Lys Val 
        115                 120                 125             


His Pro Tyr Ala Lys Asn Pro Pro Asp Pro Ser Asn Pro Lys Gly Asp 
    130                 135                 140                 


Gln Asn Ala Val Leu Ile Leu Lys Asn Gly Asp Arg Leu Pro Ser Pro 
145                 150                 155                 160 


Thr Asp Ser Arg Gly Arg Trp His Gly Ala Leu Trp Lys Thr Thr Ser 
                165                 170                 175     


Asp Gly Asp Pro Asp Tyr Ala Ser Thr Ala Asn Ala Ile Ile Asn His 
            180                 185                 190         


Ile Phe Ser Asn Glu Val Leu Ile Gly Gly His Tyr Leu Ser Asp Trp 
        195                 200                 205             


Ser Gly Lys Gly Ser Lys Ser Ser Val Gly Leu Ala Glu Arg Arg Gly 
    210                 215                 220                 


Asp Ser Ile Arg Ser Ser Thr Pro Asp Leu Lys Leu Pro Ile Gly Pro 
225                 230                 235                 240 


Gly Ala Ser Ala Arg Leu Leu Leu Asp Leu Asp Asp Gln Asn Ala Lys 
                245                 250                 255     


Pro Ile Ile Lys Leu Phe Phe His Gln Asp Ile Ala Ala Lys Ile Tyr 
            260                 265                 270         


Ala Phe Val Leu Glu Arg Ala Arg Val Asp Gly Pro Arg Lys Pro Asn 
        275                 280                 285             


Val Ala Phe Ser Val Arg Ser Ser Asp Phe Gly Arg Leu Leu Ser Lys 
    290                 295                 300                 


His Phe Gly Asp Val Pro Asn His Arg Asp Phe Asp Asp Glu Thr Lys 
305                 310                 315                 320 


Ile Lys Ile Val Ala Phe Tyr Asp Arg Val Lys Arg Tyr Tyr Ala Ala 
                325                 330                 335     


Leu Ser Lys Ser Glu Ser Phe Arg Arg Ala Ile Ala Lys Ala Glu Ile 
            340                 345                 350         


Ser Lys Leu Glu Ala Ile Leu Pro Arg Asp Lys Ser His Leu Leu Ala 
        355                 360                 365             


Val Leu Ala Gly Lys Glu Arg Asn Thr Glu Ile Ser Ser Leu Ile Arg 
    370                 375                 380                 


Phe Gly Lys Leu Val Gly His Ala Cys Asp Ile Ser Pro Val Val Glu 
385                 390                 395                 400 


Val Gln Thr Ala Phe Asp Asn Asn Val Arg His Leu Ala Thr Ser Asp 
                405                 410                 415     


Gly Gln Ser Glu Ile Lys Arg Asn Glu Asn Phe Thr Arg Val Trp Arg 
            420                 425                 430         


Thr Ser Val Ala Phe Ser Leu Arg Thr Leu Asp Ser Trp Leu Lys Pro 
        435                 440                 445             


Asp Trp Pro Lys Leu Thr Glu Asp Glu Ala Arg Arg Arg Asn Asp Arg 
    450                 455                 460                 


Asn Pro Gly Gly Gln Gln Ile Asn Lys Ser Ala Leu Glu Arg Asp Ile 
465                 470                 475                 480 


Ala Gln Met Arg Tyr Ile Lys Thr Ile Ala Gly Glu Glu Pro Val Glu 
                485                 490                 495     


Gly Phe Leu Asn Gly Ala Gly Ile Ile Phe Gly Ser Lys His Val Glu 
            500                 505                 510         


Phe Glu Gly Glu Ala Ala Arg Arg Cys Glu Ile Phe Ala Gln Gly Asp 
        515                 520                 525             


Lys Ala Lys Asn Arg Glu Leu Val Trp Ala Trp Leu Arg Leu Ala Ala 
    530                 535                 540                 


Glu Met Arg His Arg Thr Asn His Phe Ser Thr Lys Pro Arg Leu Val 
545                 550                 555                 560 


Ser Leu Met Gln Lys Gly Val Leu Ser Pro Thr Arg Asp Asn Pro Gly 
                565                 570                 575     


Asn Phe Glu Asn Arg Lys Gly Asn Glu Val Gln Gln Ala Ala Leu Asp 
            580                 585                 590         


Ala Phe Gly Gln Leu Leu Ser Phe Asp Ile Asn Tyr Gln Ala Ile Leu 
        595                 600                 605             


Leu Val Asn Asp Phe Asn Arg Leu Gln Val Thr Arg Tyr Thr Ser Asp 
    610                 615                 620                 


Gly Gln Phe Lys Asp Val Leu Arg Arg Ala Leu Ser Thr Asp Asp Asp 
625                 630                 635                 640 


Pro Val Ile Thr Thr Pro Lys Phe Met Ser Val Leu Arg Lys Ala Lys 
                645                 650                 655     


Gly Ile Phe Asp His Asp Leu Glu Ser Ala Pro Glu Trp Ser Lys Phe 
            660                 665                 670         


Leu Gly Ser Leu Asp Leu Thr Ala Leu Ser Ala Ala Pro Asp Gly Pro 
        675                 680                 685             


Asn Gln Phe Lys Ile Gly Leu Leu Arg His Leu Phe Ala Thr Asp Phe 
    690                 695                 700                 


Gln Ser Trp Leu Ala Arg Lys Ala Asn Thr Lys Asp Gln Ile Gln Ala 
705                 710                 715                 720 


Ala Val Val Ala Val Ser Glu Asp Lys Asn Arg Arg Thr Leu Asp Val 
                725                 730                 735     


Leu Lys Asn Glu Glu Ser Arg Val Tyr Ala Val Ala Glu Thr Ala Ala 
            740                 745                 750         


Lys Met Leu Ile Phe Ala Lys Ala Asp Ser Phe Ser Glu Leu Ala Ala 
        755                 760                 765             


Leu Val Met Ser Met Ala Phe Ala Glu Asp Asn Thr Arg Lys Ser Tyr 
    770                 775                 780                 


Lys Pro Lys Pro Glu Glu Gln Ser Lys Arg Ser Thr Trp Val Asp Asp 
785                 790                 795                 800 


Phe Gln Arg Asp Leu Phe Val Tyr Leu Phe Asn His Tyr Leu Asn Thr 
                805                 810                 815     


Gln Ser Leu His Trp Ile Phe Asp Val Thr Asp Leu Val Gly Asp Gly 
            820                 825                 830         


Glu Ala Arg Thr Val Thr Leu Phe Asp Leu Gly Ala Gly Arg Trp Ser 
        835                 840                 845             


Leu Glu Ser Lys Pro Trp His Ser Gln Phe Tyr Ala Trp Leu Tyr Leu 
    850                 855                 860                 


Thr Pro Val Asp Glu Val Ala Leu Leu Arg Asn Gln Met Arg Arg Met 
865                 870                 875                 880 


Leu Ile Leu Glu Lys Lys Gly Gly Ser Asn Glu Thr Pro Ala Leu Arg 
                885                 890                 895     


Asp Leu Asp Arg Leu Met Thr Leu Tyr Ile Ala Val Ser Ser Ala Gly 
            900                 905                 910         


Phe Asp Gly Thr Glu His Ile Gln Thr Thr Ala Glu Asp Asp Lys Arg 
        915                 920                 925             


Phe Arg Leu Tyr Gly Gly Leu Leu Tyr Glu Asp Ala Val Gln Phe Glu 
    930                 935                 940                 


Lys Val Tyr Ser Ala Ala Ala Asp Thr Asn Asp Gln Ser Leu Pro Gly 
945                 950                 955                 960 


Thr Arg Arg Gly Leu Arg Gln Ile Ala Arg Leu Gly His Ile Ser Val 
                965                 970                 975     


Leu Lys Gly Ile Phe Glu Lys His Leu Ile Thr Pro Asp Glu Val Ser 
            980                 985                 990         


Thr Leu Ile Glu Thr Lys Lys Ala  Lys Ser Phe Lys Asp  Ala Thr Lys 
        995                 1000                 1005             


Arg Ala  Lys Leu His Asn Glu  Ile Val Thr Leu Ser  Lys Gly Phe 
    1010                 1015                 1020             


Lys Pro  Asp Ile His Gln Leu  Asp Lys Lys Cys Lys  Glu Tyr Lys 
    1025                 1030                 1035             


Asp Leu  Ser Ala Glu Ile Thr  Val His Asn Phe Lys  Ala Ala Gly 
    1040                 1045                 1050             


Ala Arg  Leu Thr Glu His Ala  Arg Leu His Gln Leu  Leu Met Arg 
    1055                 1060                 1065             


Val Ile  Ser Arg Leu Ala Asp  Phe Thr Leu Ile Trp  Glu Arg Asp 
    1070                 1075                 1080             


Arg Asn  Tyr Val Leu Leu Ala  Leu Ile Tyr Pro Lys  Leu Leu His 
    1085                 1090                 1095             


Pro Asp  Glu Asn Ala Pro Arg  Leu His Arg Arg Asp  Gly Lys Val 
    1100                 1105                 1110             


Gly Phe  Leu Leu Pro Pro Glu  Thr Thr Lys Thr Met  Arg Ala Ala 
    1115                 1120                 1125             


His Ala  Pro Leu Ser Asp Asn  Asp Lys Arg Lys Leu  Ser Arg Glu 
    1130                 1135                 1140             


Ile Ala  Leu Thr Ser Glu Asn  Val Glu Glu Gly Phe  Leu Pro Leu 
    1145                 1150                 1155             


Trp Asp  Asp Asp Met Gly Tyr  Arg Leu Thr Gly Tyr  Pro Ile His 
    1160                 1165                 1170             


Leu Ala  Leu Leu Glu Met Asp  Lys Arg Asp Ala Phe  Ala Arg Phe 
    1175                 1180                 1185             


Phe Asp  Arg Ser Glu Thr Glu  Asn Pro Leu Asp Val  Ala Glu Arg 
    1190                 1195                 1200             


Ala Arg  Ile Lys Arg Gly Thr  Gly Asn Ser Ser Pro  Leu Gln Arg 
    1205                 1210                 1215             


Arg Gln  Leu Thr Phe Lys Asp  Gly Lys Arg Arg Ile  Arg Asn Asp 
    1220                 1225                 1230             


Phe Ala  His Phe Asn Val Ile  Val Ser Asp Arg Lys  Arg Val Ser 
    1235                 1240                 1245             


Leu Thr  Tyr Leu Met Asn Ala  Val Arg Ser Leu Val  Ala Tyr Asp 
    1250                 1255                 1260             


Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ala Val Ala  Asp Ile Leu 
    1265                 1270                 1275             


Val Asp  Glu Gly Leu Asp Ile  Ser Trp Glu Met Thr  Gly Asp Arg 
    1280                 1285                 1290             


Leu Arg  Asn Pro Val Val Val  Pro Arg Leu Glu Thr  Asn Leu Lys 
    1295                 1300                 1305             


Lys Val  Arg Lys His Arg Gly  Leu Ala Asp Pro Gln  Phe Val Leu 
    1310                 1315                 1320             


Pro Leu  Ala Ser Val Arg Tyr  Thr Ser Met Val Lys  Ala Leu Phe 
    1325                 1330                 1335             


Asp Phe  Gln Ala Gly Gly Tyr  Arg Lys Glu Ile Ile  Val Gly Gln 
    1340                 1345                 1350             


Glu Thr  Lys Gln Arg Gly Glu  Leu Gly Tyr Pro Val  Glu Leu Arg 
    1355                 1360                 1365             


Val Leu  Leu Gly Ser Leu Gly  Ala Asp Met Pro Asp  Asp Val Leu 
    1370                 1375                 1380             


Gly Met  Lys Leu Tyr Val Ile  Gln Pro Gln Lys 
    1385                 1390                 


<210>  1117
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1117

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  1118
<211>  1092
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1118

Met Leu Lys Ile Phe Phe Lys Asp Ser Ile Pro His Tyr Leu Tyr Phe 
1               5                   10                  15      


Asp Leu Lys Phe Ser Asn Tyr Tyr Leu Thr Phe Ala Cys Asn Phe Asp 
            20                  25                  30          


Leu Asn Arg Phe Glu Met Lys Phe Ser Lys Val Lys Ile Gly Lys Val 
        35                  40                  45              


Pro Tyr Ser Phe Tyr Arg Asp Arg Lys Lys Gly Val Leu Leu Arg Gly 
    50                  55                  60                  


Glu Asp Ile Asn Cys Gln Ser Lys Asn Leu Leu Met Lys Tyr Arg Gly 
65                  70                  75                  80  


Ser His Phe Asp Met Ser Ile Ile Asp Ile Thr Leu Ala Lys Glu Ile 
                85                  90                  95      


Pro Gly Arg Lys Asn Arg Asn Thr Tyr Val Glu Ser Ile Ile Asn Asn 
            100                 105                 110         


Ile Val Lys Asn Asn Lys Gln Ser Tyr Cys Pro Lys Leu Thr Pro Asp 
        115                 120                 125             


Glu Val Arg Asn Ser Leu Asn Ala Lys Phe Arg Asn Lys Ile Lys Tyr 
    130                 135                 140                 


Tyr Pro Asp Asn Thr Ile Glu Tyr Lys Glu Phe Ser Leu Val Asp Leu 
145                 150                 155                 160 


Ile Cys Glu Tyr Ser Leu Thr Asn Asp Ile Glu Val Leu Lys Pro Tyr 
                165                 170                 175     


Leu Asp Trp Ser Lys Trp Tyr Leu Asn Arg Lys Leu Lys Tyr Phe Phe 
            180                 185                 190         


Lys Ser Val Ala His Asn Lys Ile Asp Leu Ser Tyr Leu Ile Ser Asp 
        195                 200                 205             


Thr Gln Ser Lys Arg Lys Arg Val Leu Ile Ser Leu Tyr Asn Leu Gly 
    210                 215                 220                 


Met Glu Lys Arg Lys Ile Val Tyr Tyr Glu Lys Leu Glu Lys Thr Tyr 
225                 230                 235                 240 


Asn Phe Pro Thr Leu Cys Asn Arg Phe Glu Val Ile Ile Thr Asn Cys 
                245                 250                 255     


Asp Ile Lys Asn Gln Leu Pro Ser Asn Ile Gln Ile Lys Lys Ala Leu 
            260                 265                 270         


Gln Glu His Gln Lys Thr Ile Phe Gly Thr Arg Glu Asn Pro Leu Asn 
        275                 280                 285             


Arg Asn Asp Asp Tyr Leu Ala Ile Tyr Asn Asn Glu Val Val Lys Tyr 
    290                 295                 300                 


Phe Glu Arg Tyr Phe Pro Val Lys Arg Thr Lys Arg Arg Tyr Ser Leu 
305                 310                 315                 320 


Asn Leu Met Lys His Tyr Leu Ser Ser Gln Thr Ile Ile Ser Thr Ile 
                325                 330                 335     


Arg Arg Gln Phe Glu Asn Ser Ile Arg Val Tyr Ile Met Gln Val Lys 
            340                 345                 350         


Arg Ile Lys Ile His Asn Val Lys Leu Lys Arg Leu Asn Ser Ser Ile 
        355                 360                 365             


Leu Ser Arg Ile Lys Leu Asn Asp Asp Phe Ile Ser Asn Ile Gln Ile 
    370                 375                 380                 


Ile Ser Ala Phe Ala Thr Ser Asn Leu Arg Asn Ile Phe Asn Leu Ser 
385                 390                 395                 400 


Phe Tyr Ala Asp Phe Tyr Asp Ala Asn Met Phe Ile Gln Leu Asn Leu 
                405                 410                 415     


Lys Asn Ile Asn Lys Asp Ile Phe Lys Met Tyr Phe Asp Glu Asp Phe 
            420                 425                 430         


Asn Ser Asn Asn Ser Thr Tyr Leu Ala Leu Arg Ser Ser Leu Ile Phe 
        435                 440                 445             


Gln Glu Asn Ser Ile Leu Pro Tyr Tyr Ser Asp Ile Ile Lys Glu Leu 
    450                 455                 460                 


Phe Asp Lys Glu Phe Phe Thr Tyr Pro Asp Asn Tyr Lys Asp Asp Asn 
465                 470                 475                 480 


Asn Gly Lys Asn Leu Phe Tyr Lys Asp Thr Ile Phe Lys Asp Tyr Leu 
                485                 490                 495     


Glu Lys Asp Ile Asp Leu Ile Pro Lys Tyr Phe Ala Asp Ile Leu Lys 
            500                 505                 510         


Asn Lys Gly Ile Thr Ser Tyr Tyr Ser Ile Glu Asp Leu Ile Ser Ile 
        515                 520                 525             


Phe Ser Asn His Lys Leu Ser Leu Asn Ala Glu Ile Lys Ala Phe Ala 
    530                 535                 540                 


Pro Ser Phe Glu Arg Ile Phe Asn Ser Gly Cys Asn Tyr Gln Thr Lys 
545                 550                 555                 560 


Thr His Asp Lys His Phe Leu Asn Ile Thr Asn Tyr Tyr Pro Lys Asp 
                565                 570                 575     


Tyr Leu Asn Gln Glu Thr Lys Glu Glu Phe Ser Ala Arg Tyr Ser Leu 
            580                 585                 590         


Leu Lys Phe Ile Tyr Glu Tyr Leu Phe Leu His Asp Phe Asn Asp Ile 
        595                 600                 605             


Arg Leu Met Asn Val Ser Lys Tyr Ile Ile Asp Lys Asn Ser Gln Tyr 
    610                 615                 620                 


Ala Glu Glu Lys His Lys Ala Asp Lys Tyr Ala Tyr Lys Ser Met Lys 
625                 630                 635                 640 


Ile Met Thr Glu Lys Gln Ser Val Met Met Tyr Leu Ser Asn Ile Lys 
                645                 650                 655     


Lys Met Ile Glu Asn Glu Asn Ile Ile Lys Asn His Asn Tyr Ser Tyr 
            660                 665                 670         


Tyr Asn Lys Gly Asn Lys Asn Tyr Ser Glu Lys Phe Leu Ile Asp Ile 
        675                 680                 685             


Phe Val Lys Ala Phe Asp Val Phe Leu Asn Gln Phe Ser Lys His Ile 
    690                 695                 700                 


Ile His Lys Thr His Lys Gln Thr Pro Lys Asn Thr Ile Asn Leu Asn 
705                 710                 715                 720 


Ile Lys Glu Thr Ser Ile Asn Pro Asn Asn Ser Ser His Ile Arg Phe 
                725                 730                 735     


Tyr Ile Phe Ala Lys Leu Leu Asp Glu Tyr Asn Leu Asn Lys Leu Arg 
            740                 745                 750         


Asn Glu Ile Ile Lys Tyr Lys Asn Leu Lys Ile Leu Thr Glu Ile Ile 
        755                 760                 765             


Asp Lys Ser Tyr Lys Ile Asp Glu Arg Leu Lys Thr Asp Tyr Leu Ile 
    770                 775                 780                 


Glu Ile Thr Glu Leu Cys Leu Leu Lys Leu Arg Ser Gln Arg Lys Ile 
785                 790                 795                 800 


Glu Phe Asn Tyr Ile Glu Asn Trp Ile Asp Ile Lys Leu Leu Asn Tyr 
                805                 810                 815     


Thr Asn Ile Asp Asn Tyr Asp Lys Ile Asp Thr Gln Lys Ile Lys Ser 
            820                 825                 830         


Asn Leu Tyr Tyr Ile Lys Lys Tyr Ser Thr Glu Lys Ile Phe Asp Phe 
        835                 840                 845             


Leu Phe Asn Gln Tyr Pro Gln Tyr Lys Val Ser Tyr Ser Asp Ile Ile 
    850                 855                 860                 


Lys Tyr Lys Glu Tyr Leu His Asn Glu Glu Asn Gly His Arg Ile Ile 
865                 870                 875                 880 


Asp Asn Ile Tyr Tyr Thr Lys Tyr Asn Ile His Lys Ser Trp Val His 
                885                 890                 895     


Lys Thr Phe Lys Ala Tyr Asp Ile Thr Glu Asp Glu Leu Ile Phe Asn 
            900                 905                 910         


Pro His Ser Leu Glu Tyr Lys Asn Leu Ile His Gln Leu Gln Glu Phe 
        915                 920                 925             


Asp Ser Leu Glu Arg Lys Ile His Leu Thr His Leu Lys Glu Ser Ser 
    930                 935                 940                 


Gln Leu Leu Asn Glu Ile Phe Gln Lys Leu Ile Arg Tyr Ile Thr Ile 
945                 950                 955                 960 


Leu Asp Arg Asp Lys Glu Tyr Leu Lys Gly Glu Ile Leu Asn Tyr Asn 
                965                 970                 975     


Thr Ser His Phe Asn Gln Gln Ile His Tyr Ile Arg His Leu Asn Tyr 
            980                 985                 990         


Tyr Phe Asp Lys Asp Phe Lys Tyr  Ser Ile Ile Asp Leu  Ile Asn Tyr 
        995                 1000                 1005             


Thr Arg  Glu Ile Met Thr Tyr  Asn Arg Ala Ile Lys  Asn Ser Val 
    1010                 1015                 1020             


Tyr Lys  Ser Ile Ile Lys Ile  Phe Glu Asp Asn Gly  Met Glu Leu 
    1025                 1030                 1035             


Lys Met  Thr His Asn Ile Glu  Thr Tyr Lys Leu Glu  Ile Gln Tyr 
    1040                 1045                 1050             


Ile Arg  Pro Lys Arg Ile Tyr  His Leu Lys Thr Thr  Pro Arg Lys 
    1055                 1060                 1065             


Gly Asn  Ile Tyr Glu Tyr Met  Val Ser Gln Glu Tyr  Cys Asp Phe 
    1070                 1075                 1080             


Cys Arg  Thr Leu Met Glu Met  Lys Ser 
    1085                 1090         


<210>  1119
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1119

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  1120
<211>  1385
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1120

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Pro Gly Thr Asp Thr 
            20                  25                  30          


Ile Asp Leu Asn Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Thr Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Asp Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Glu Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Gly Leu Phe Val Asn Ile 
                325                 330                 335     


Pro Asp Val Leu Met Lys Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Ile Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Ser Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg 
465                 470                 475                 480 


Asn Gly Ile Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Tyr Glu Asn 
                485                 490                 495     


Leu Gln Arg Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu 
            500                 505                 510         


Ala Arg Ala Val Cys Asp Met Ser Asn Leu Lys Asp Arg Glu Ser Asp 
        515                 520                 525             


Phe Leu Leu Trp Lys Lys Glu Asp Ile Ala Asp Lys Leu Lys Asn Lys 
    530                 535                 540                 


Asp Asp Met Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys 
545                 550                 555                 560 


Ser Ser Trp Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn 
                565                 570                 575     


Lys Tyr Asn Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile 
            580                 585                 590         


Tyr Cys Ala Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn 
        595                 600                 605             


Asn Glu Lys Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu 
    610                 615                 620                 


Thr Glu Phe Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn 
625                 630                 635                 640 


Leu Tyr Met Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Gln 
                645                 650                 655     


Leu Tyr Ser Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn 
            660                 665                 670         


Ser Val Phe Ile Arg Lys Asn Phe Pro Glu Asp Ile Thr Asn Val Leu 
        675                 680                 685             


Arg Tyr Gln Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr 
    690                 695                 700                 


Ser Ala Cys Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu 
705                 710                 715                 720 


Gln Ser Asp Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu 
                725                 730                 735     


Ser Trp Asp Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn 
            740                 745                 750         


His Phe Ser Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys 
        755                 760                 765             


Gln Ile Tyr Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys 
    770                 775                 780                 


Val Arg Ser Ser Asn Asp Ser Ile Phe Asp Lys Pro Ile Tyr His His 
785                 790                 795                 800 


Tyr Lys Val Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr 
                805                 810                 815     


Leu Lys Tyr Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys 
            820                 825                 830         


Ala Asn Glu Ile Arg Lys Ile Asp Lys Glu Arg Phe Leu Pro Asp Trp 
        835                 840                 845             


Thr Ser Thr Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln 
    850                 855                 860                 


Glu Leu Gln Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser 
865                 870                 875                 880 


Leu Asn Leu Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr 
                885                 890                 895     


Asp Ile Lys Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser 
            900                 905                 910         


Val Gln Asp Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val 
        915                 920                 925             


Cys Ser Leu Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe 
    930                 935                 940                 


Asn Asp Lys Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe 
945                 950                 955                 960 


Ser Asn Ala Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser 
                965                 970                 975     


Asn Glu Glu Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val 
            980                 985                 990         


Asn Arg Asn Ile Val His Ser Lys  Leu Phe Ala Ala Asp  His Ile Leu 
        995                 1000                 1005             


Arg Asp  Ile Val Glu Pro Val  Ser Lys Asp Asn Ile  Glu Glu Phe 
    1010                 1015                 1020             


Tyr Asp  Gln Lys Ala Glu Ile  Val Tyr Cys Lys Ile  Lys Gly Lys 
    1025                 1030                 1035             


Asp Ile  Thr Ala Glu Glu Gln  Lys Ala Val Leu Lys  Tyr Gln Lys 
    1040                 1045                 1050             


Leu Lys  Asn Arg Val Glu Leu  Arg Asp Ile Val Glu  Tyr Gly Glu 
    1055                 1060                 1065             


Ile Ile  Asn Glu Leu Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met 
    1070                 1075                 1080             


Arg Glu  Arg Asp Leu Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn 
    1085                 1090                 1095             


Cys Leu  Arg Asn Asn Ser Glu  Lys Lys Glu Ala Tyr  Gln Lys Ile 
    1100                 1105                 1110             


Glu Val  Asn Gly Asp Ser Ile  Lys Asp Ala Ile Leu  Tyr Gln Ile 
    1115                 1120                 1125             


Ile Gly  Met Tyr Val Asn Gly  Val Ala Val Tyr Ala  Pro Asp Glu 
    1130                 1135                 1140             


Lys Gly  Asp Ile Leu Lys Glu  Gln Cys Thr Lys Gly  Gly Ala Gly 
    1145                 1150                 1155             


Gly Lys  Ile Ser Ala Phe Asn  Arg Tyr Ser Glu Tyr  Leu Gly Leu 
    1160                 1165                 1170             


Asp Lys  Leu Thr Leu Tyr Asn  Ala Gly Leu Glu Ile  Phe Glu Val 
    1175                 1180                 1185             


Val Ala  Glu His Asp Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp 
    1190                 1195                 1200             


His Phe  Lys Tyr Tyr Leu Gly  Asp Tyr Arg Ser Met  Leu Ser Ile 
    1205                 1210                 1215             


Tyr Ser  Glu Val Phe Asp Arg  Phe Phe Thr Tyr Asp  Ile Lys Tyr 
    1220                 1225                 1230             


Gln Lys  Asn Val Leu Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His 
    1235                 1240                 1245             


Asn Val  Ile Val Glu Pro Val  Leu Glu Ser Gly Phe  Lys Thr Ile 
    1250                 1255                 1260             


Gly Lys  Gln Thr Thr Ser Gly  Ala Lys Leu Ser Ile  Arg Ser Ile 
    1265                 1270                 1275             


Lys Ser  Asp Thr Phe Gln Tyr  Lys Val Lys Gly Gly  Ser Leu Ile 
    1280                 1285                 1290             


Thr Asp  Ala Lys Asp Glu Arg  Tyr Leu Lys Thr Ile  Arg Lys Ile 
    1295                 1300                 1305             


Leu Tyr  Tyr Val Glu Asn Glu  Glu Asp Asn Leu Lys  Lys Ser Val 
    1310                 1315                 1320             


Val Val  Thr Asn Ala Asp Lys  Tyr Glu Lys Asn Lys  Glu Ser Asp 
    1325                 1330                 1335             


Asp Gln  Asn Lys Gln Lys Glu  Lys Lys Asn Lys Asp  Asn Lys Gly 
    1340                 1345                 1350             


Lys Lys  Asn Glu Glu Thr Lys  Ser Asp Ala Gly Lys  Asn Asn Asn 
    1355                 1360                 1365             


Glu Arg  Leu Ser Tyr Asn Pro  Phe Ala Asn Leu Asn  Phe Lys Leu 
    1370                 1375                 1380             


Pro Asn  
    1385 


<210>  1121
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1121

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  1122
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1122

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  1123
<211>  1315
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1123

Met Ile Ile Ile Lys Lys Phe Gly Arg Ser Val Ile Thr Gln Asp Lys 
1               5                   10                  15      


Asn Thr Asp Asn Lys Arg Glu Arg Glu Leu Asp Thr Ser Ala Arg Ala 
            20                  25                  30          


Lys Ala Lys Ser Gln Asn Ser Gln Val Phe Pro Phe Leu Asn Lys Lys 
        35                  40                  45              


Glu Asp Phe Ile Asn Leu Trp Ile Ser Glu Phe Asp Lys Leu Ile Tyr 
    50                  55                  60                  


Lys Pro Lys Gly Asp Asp Lys Pro Thr Lys Glu Met Tyr Thr Leu Arg 
65                  70                  75                  80  


Glu Ala Ala Gly Lys Gly Phe Leu Asn Tyr Trp Asn Gln Met Pro Met 
                85                  90                  95      


Val Ser Lys Lys Asp Gly Ala Phe Ser Asp Met Trp Met Ser Lys Val 
            100                 105                 110         


His Pro Tyr Gly Arg Gly Ile Thr Glu Phe Ser Pro Pro Leu Gln Leu 
        115                 120                 125             


Glu Lys Leu Ile Asp Gln Gly Leu Leu Ser Ala Met Gly Gly Ser Glu 
    130                 135                 140                 


Pro Leu Lys Asn Cys His Trp Asn Arg Val Thr Ser Asn Val Phe Lys 
145                 150                 155                 160 


Gly Leu Lys Val Gln Leu Asp Ile Leu Glu Ala Gln Ala Lys Asn Thr 
                165                 170                 175     


Phe Val Ile Lys Asn Lys Thr Asn Ser Lys Arg Asn Arg Pro Ala Ser 
            180                 185                 190         


Gln Asn Ile Lys Glu Phe Leu Leu Thr Asp Glu Thr Ala Phe Ile Asn 
        195                 200                 205             


Leu Trp Ile Ser Glu Phe Asp Lys Leu Ile Leu Lys Pro Gln Gly His 
    210                 215                 220                 


Asn Lys Pro Thr Glu Lys Met Tyr Asn Leu Arg Gln Gln Ala Gly Val 
225                 230                 235                 240 


Ala Phe Leu Asn Tyr Trp Lys Lys Lys Pro Leu Ile Pro Trp Ala Asn 
                245                 250                 255     


Ser Glu Ser Phe Pro Asp Lys Trp Met Leu Lys Val His Pro Tyr Gly 
            260                 265                 270         


Asp Lys Thr Ser Asn Asn Arg Ser Glu Thr Leu Ile Lys Ser Lys Trp 
        275                 280                 285             


Gly Ser Val Met Arg Ala Lys Glu Cys Leu Ser Asp Asp Gln Trp Glu 
    290                 295                 300                 


Gln Val Ala Phe Asn Val Tyr Ser His Leu Tyr Gly Asn Gln Lys Thr 
305                 310                 315                 320 


Leu Asn Gly Lys Asn Lys Glu Ile Gly Leu Ile Ala Ala Arg Ala Asn 
                325                 330                 335     


Ser Ile Lys Gln Asn Val Pro Ser Tyr Thr Leu Asp Lys Asp Asn Asn 
            340                 345                 350         


Phe Leu Ser Asp Lys Lys Asp Lys Leu Arg Tyr Ile Ala Ala Leu Arg 
        355                 360                 365             


Gly Glu Gly Ile Lys Trp Glu Glu Val Lys Asp Arg Tyr Lys Trp Lys 
    370                 375                 380                 


Glu Leu Thr Gln Leu Ile Asn Ile Glu Glu Ile Asp Ser Thr Asp Ile 
385                 390                 395                 400 


Ala Lys Arg Lys Gln His Leu Ala Glu Cys Phe Tyr Thr His His Gly 
                405                 410                 415     


Arg Ile Phe Gly Asp Ile Gln Asn Ser Lys Ile Glu Asp Lys Asp Cys 
            420                 425                 430         


Phe Leu Tyr His Ser Leu Val Lys Glu Ile Leu Phe Glu Cys Ile Glu 
        435                 440                 445             


Lys Lys Gln Asp Phe Leu Asn Asp Thr Glu Val His Gln Arg Leu Ile 
    450                 455                 460                 


Tyr Lys Glu Asn Asn Arg Ile Met Ala Thr Ala Val Ser Ile Gly Lys 
465                 470                 475                 480 


Leu Ile His Tyr Gln Gly Gly Ile Glu Ala Ile Gly Asn Lys Glu Asp 
                485                 490                 495     


Leu Val Asn Ser Lys Phe Leu Thr Asp Ala Gly Leu Thr Glu Ile Lys 
            500                 505                 510         


Gln Asn Glu Ser Phe Val Arg Gln Trp Leu Glu Leu Ile Ala Ile Ala 
        515                 520                 525             


Asn Thr Thr Leu Ser Gln Leu Val Asp Pro Asp Gly Lys His Glu Asp 
    530                 535                 540                 


Ile Phe Ala Ala Thr Ser Phe Asp Asp Ala Leu Lys Gly Leu Asn Asn 
545                 550                 555                 560 


Ile Ser Asp Phe Asp Ser Lys Phe Lys Leu Leu Phe Gly Glu Asn His 
                565                 570                 575     


Arg Leu Tyr Asp Asp Asp Thr Glu Arg Gln Lys Leu Leu Arg Ile Ile 
            580                 585                 590         


Tyr Asp Thr Ile Ser Ala Leu Arg Asn Ala Ser Phe His Phe Lys Asn 
        595                 600                 605             


Ile Gln Gly Phe Asn Lys Ala Leu Glu Asp Asn Leu Ser Thr Lys Gly 
    610                 615                 620                 


Arg Arg Gln Lys Gly Val Val Asp Lys Ile Ile Glu Tyr Thr Lys Val 
625                 630                 635                 640 


His Gln Gln Lys Gln His Glu Leu Leu Ile Ala Asp Leu Lys Ala Ala 
                645                 650                 655     


Asn Val Glu Asp Tyr Leu Ser Gln Leu Gln Leu Asp Tyr Leu Phe Glu 
            660                 665                 670         


Val Val Cys Lys Gly Glu Arg Glu Leu Leu Asp Met Pro Lys Phe Ser 
        675                 680                 685             


Lys Leu Leu Leu Arg Ala Gly Glu Ile Gly Glu Lys Ile Ile Ser Pro 
    690                 695                 700                 


Val Asn Ala Thr Ala Met Glu His Pro Ala Tyr Gln Cys Cys Phe Ile 
705                 710                 715                 720 


Ser Leu Lys Met Leu Tyr Asp Gln Asp Phe Val Asn Trp Leu Lys Lys 
                725                 730                 735     


Gln Ser Asn Lys Asn Ile Ala Ser Trp Met Asp Ser Ala Lys Thr Arg 
            740                 745                 750         


Ala Thr Asn Ala Ala Lys Lys Ile Phe Arg Asn Gly Thr Asn Ile Ser 
        755                 760                 765             


Ser Lys Met Ala Arg Leu Arg Asn Ile Val Glu Asp Glu Thr Leu Val 
    770                 775                 780                 


Glu Tyr Phe Ser Phe Ile Thr Ala Glu Thr Ala Asn Glu Phe Gln Val 
785                 790                 795                 800 


Gln Gln Gln Lys Asn Arg Tyr Gln Ser Asn Ser Ala Ser Ala Lys Glu 
                805                 810                 815     


Gln Ser Asn Phe Val Glu Gln Phe Lys Gln Asp Phe Leu Ile Tyr Ala 
            820                 825                 830         


Phe Lys Gly Tyr Ile Gly Asp Ile Lys Phe Gly Lys Leu Asp Gln Gly 
        835                 840                 845             


Glu Lys Leu Leu Lys Cys Asn Ala Lys Gly Ser Leu Leu Pro Glu Asn 
    850                 855                 860                 


Asn Arg Ser Asp Thr Gly Ala Glu Asp Ile Glu Arg Pro Trp Leu Tyr 
865                 870                 875                 880 


Leu Val Leu His Leu Val Pro Ile Glu Val Val Asn Arg Ile Thr Leu 
                885                 890                 895     


Gln Ile Lys Lys His Ser Val Leu Thr Asn Ser Thr Leu Asp Asp Thr 
            900                 905                 910         


Arg Ala Ala Tyr Thr Asp Ile His Gln Ala Phe Ser Leu Tyr Leu Gly 
        915                 920                 925             


Val His Gly Ala Ile Leu Gly Leu Gln Ser Leu Ser Asn Glu Pro Glu 
    930                 935                 940                 


Leu Gln Val Phe Phe Glu Lys Glu Ser Asp Phe Asn Asn Leu Phe Thr 
945                 950                 955                 960 


Asp Asn Gly Glu Gly Leu Val Pro Val Lys Gly Leu Arg Asp Ile Leu 
                965                 970                 975     


Arg Phe Gly Asn Leu Glu Gln Leu Lys Lys Met Phe Ser Asp Lys Lys 
            980                 985                 990         


Val Ala Ser Asp Asp Ile Thr Asn  Leu Lys Glu Tyr Leu  Glu Ala Thr 
        995                 1000                 1005             


Gly Gly  Lys Ser Lys Ile Ala  Arg Ala Gln Glu Lys  Arg Ile Glu 
    1010                 1015                 1020             


Leu His  Lys Thr Leu Thr Glu  Leu Pro Lys Arg Leu  Thr Lys Pro 
    1025                 1030                 1035             


Arg Val  Lys Gln Thr Gly Ile  Asp Thr Tyr Glu Lys  Asn Asn Asn 
    1040                 1045                 1050             


Ile Ser  Ile Ser Gly Ser Ile  Ser Glu Tyr Arg Lys  Asp Leu Lys 
    1055                 1060                 1065             


Cys Ile  Val Ser Tyr Arg Glu  Leu Lys Asn Lys Ile  Tyr Leu Tyr 
    1070                 1075                 1080             


Asn Val  Lys Gln Ala His Gln  Leu Ile Met Ala Thr  Gln Ala Arg 
    1085                 1090                 1095             


Leu Leu  Gly Tyr Ser Gln Ile  Arg Glu Arg Asp Leu  Tyr Phe Val 
    1100                 1105                 1110             


Leu Leu  Thr Gln Leu Met Leu  Arg Gly Val Thr Leu  Glu Lys Glu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Asp Lys Asp  Lys Leu Asn Ala Leu  Asp Thr Asp 
    1130                 1135                 1140             


Thr Val  Leu Asp Glu Glu Glu  Lys Lys Lys Leu Glu  Lys Gln Ile 
    1145                 1150                 1155             


Lys Pro  Glu Arg Ser Leu Lys  Asp Leu Val Glu Lys  Gly Leu Ile 
    1160                 1165                 1170             


Phe Leu  Ala Leu Asp Gln Leu  Ser Ser Ser Asp Lys  Asp Leu Lys 
    1175                 1180                 1185             


Ala Ile  His Ser Glu Ile Glu  Asp Met Phe Val Gly  Val Ser Pro 
    1190                 1195                 1200             


Asp Ser  Asp Asn Arg Asn Leu  Arg Asn Arg Leu Ala  His Phe Lys 
    1205                 1210                 1215             


Asp Leu  Gly Asn Lys Asn Leu  Ile Asn Ile Thr Ser  Gln Ile Asn 
    1220                 1225                 1230             


Glu Val  Arg Lys Met Met Ser  Tyr Asp Arg Lys Leu  Lys Asn Ala 
    1235                 1240                 1245             


Val Ser  Lys Ser Met Ile Asp  Leu Phe Glu Arg Tyr  Asn Leu Ile 
    1250                 1255                 1260             


Leu Ser  Phe Lys Val Gln Ser  His Lys Leu Gln Leu  Lys Asn Leu 
    1265                 1270                 1275             


Lys Ser  Lys Gln Ile Thr His  Leu Asn Asn Lys Gly  Ile Thr Glu 
    1280                 1285                 1290             


Asn Leu  Leu Ser Asp Asp Tyr  Val Ser Val Ile Lys  Arg Leu Leu 
    1295                 1300                 1305             


Leu Thr  Glu Gln Asn Pro Glu  
    1310                 1315 


<210>  1124
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1124

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Thr Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Asp Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Ser Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val His Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Leu Asn 
    1400                 1405                 1410         


<210>  1125
<211>  1157
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1125

Met Leu Arg Arg Met Cys Met Lys Ile Thr Lys Ile Asp Gly Ile Ser 
1               5                   10                  15      


His Lys Lys Tyr Lys Glu Lys Gly Lys Leu Ile Lys Ser Asn Glu Ile 
            20                  25                  30          


Glu Lys Asp Ile Thr Glu Glu Arg Phe Asn Asp Ile Glu Ala Lys Thr 
        35                  40                  45              


Thr Glu Leu Phe Gln Lys Thr Leu Asp Phe Tyr Val Lys Asn Tyr Glu 
    50                  55                  60                  


Asn Ser Glu Asp Gln Asn Lys Glu Arg Arg Glu Lys Ala Lys Asn Tyr 
65                  70                  75                  80  


Phe Ser Lys Val Lys Ile Leu Val Asp Asn Lys Lys Ile Thr Ile Cys 
                85                  90                  95      


Asn Glu Asn Thr Glu Lys Met Glu Ile Glu Asp Phe Asn Glu Tyr Asp 
            100                 105                 110         


Val Arg Ser Gly Lys Tyr Phe Asn Val Leu Asn Lys Ile Leu Asn Gly 
        115                 120                 125             


Glu Asn Tyr Thr Glu Glu Asp Leu Glu Val Phe Glu Asn Asp Leu Gln 
    130                 135                 140                 


Lys Arg Ile Gly Arg Ile Lys Ser Ile Lys Asn Ser Leu Glu Glu Asn 
145                 150                 155                 160 


Lys Ala His Phe Lys Lys Glu Ser Ile Asn Asn Asn Ile Ile Tyr Asp 
                165                 170                 175     


Arg Val Lys Gly Asn Asn Lys Lys Ser Leu Phe Tyr Glu Tyr Tyr Arg 
            180                 185                 190         


Ile Ser Ser Lys His Gln Glu Tyr Val Asn Asn Ile Phe Glu Ala Phe 
        195                 200                 205             


Asp Lys Leu Tyr Ser Asn Ser His Glu Ala Met Asn Asn Leu Phe Ser 
    210                 215                 220                 


Glu Ile Thr Lys Asp Ser Lys Glu Arg Asn Ile Arg Lys Thr Arg Glu 
225                 230                 235                 240 


Ala Tyr His Glu Ile Leu Asn Lys Asn Lys Thr Glu Phe Gly Glu Glu 
                245                 250                 255     


Leu Tyr Lys Lys Ile Gln Asp Asn Ile Ser Asn Phe Asp Lys Leu Leu 
            260                 265                 270         


Glu Ile Glu Pro Glu Ile Lys Glu Leu Thr Lys Ser Gln Ile Phe Tyr 
        275                 280                 285             


Lys Tyr Tyr Ile Asp Lys Val Asn Leu Asp Glu Thr Thr Ile Lys His 
    290                 295                 300                 


Cys Phe Cys His Leu Val Glu Ile Glu Val Asn Gln Leu Leu Lys Asn 
305                 310                 315                 320 


Tyr Val Tyr Ser Lys Arg Asn Ile Asn Lys Glu Lys Leu Glu Asn Ile 
                325                 330                 335     


Phe Glu Tyr Cys Lys Leu Lys Asn Leu Val Lys Asn Lys Leu Val Asn 
            340                 345                 350         


Lys Leu Asn Asn Tyr Ile Arg Asn Cys Gly Lys Tyr Asn Ala Tyr Ile 
        355                 360                 365             


Ser Asn Asn Asp Val Val Val Asn Ser Glu Lys Ile Ser Glu Ile Arg 
    370                 375                 380                 


Thr Lys Glu Ala Phe Leu Arg Ser Ile Ile Gly Val Ser Ser Ser Ala 
385                 390                 395                 400 


Tyr Phe Ser Leu Arg Asn Ile Leu Asn Thr Asp Asn Thr Gln Asp Ile 
                405                 410                 415     


Thr Asn Lys Val Asp Lys Glu Val Asp Lys Leu Tyr Gln Glu Asn Lys 
            420                 425                 430         


Lys Ile Glu Leu Glu Glu Arg Leu Lys Leu Phe Phe Gly Asn Tyr Phe 
        435                 440                 445             


Asp Ile Asn Asn Gln Gln Glu Ile Lys Val Phe Leu Met Asn Ile Asp 
    450                 455                 460                 


Lys Ile Ile Ser Ser Ile Arg His Glu Ile Ile His Phe Lys Met Glu 
465                 470                 475                 480 


Thr Asn Ala Gln Asn Ile Phe Asp Phe Asn Asn Val Asn Leu Gly Asn 
                485                 490                 495     


Thr Ala Lys Asn Ile Phe Ser Asn Glu Ile Asn Glu Glu Lys Ile Lys 
            500                 505                 510         


Phe Lys Ile Phe Lys Gln Leu Asn Ser Ala Asn Ile Phe Asp Tyr Leu 
        515                 520                 525             


Ser Asn Lys Asp Ile Thr Glu Tyr Met Asp Lys Val Val Phe Ser Phe 
    530                 535                 540                 


Thr Asn Arg Asn Val Ser Phe Val Pro Ser Phe Thr Lys Ile Tyr Asn 
545                 550                 555                 560 


Arg Val Gln Asp Leu Ala Asn Ser Leu Glu Ile Lys Glu Trp Lys Ile 
                565                 570                 575     


Pro Asp Glu Ser Glu Gly Lys Asp Ala Gln Ile Tyr Leu Leu Lys Asn 
            580                 585                 590         


Ile Tyr Tyr Gly Lys Phe Leu Asp Lys Phe Leu Asn Glu Glu Asn Gly 
        595                 600                 605             


Ile Phe Ile Ser Ile Lys Asp Lys Ile Ile Glu Leu Asn Arg Asn Gln 
    610                 615                 620                 


Asn Lys Arg Thr Gly Phe Tyr Lys Leu Glu Lys Phe Glu Lys Ile Glu 
625                 630                 635                 640 


Glu Thr Asn Pro Lys Lys Tyr Leu Glu Ile Ile Gln Ser Leu Tyr Met 
                645                 650                 655     


Ile Asn Ile Glu Glu Ile Asp Ser Glu Gly Lys Asn Ile Phe Leu Asp 
            660                 665                 670         


Phe Ile Gln Lys Ile Phe Leu Lys Gly Phe Phe Glu Phe Ile Lys Asn 
        675                 680                 685             


Asp Tyr Asn Tyr Leu Leu Glu Leu Lys Lys Val Gln Asp Lys Lys Asn 
    690                 695                 700                 


Ile Phe Asp Ser Lys Met Ser Glu Tyr Ile Ala Gly Glu Lys Thr Leu 
705                 710                 715                 720 


Glu Asp Ile Gly Glu Ile Asn Glu Ile Ile Gln Lys Ile Glu Ile Thr 
                725                 730                 735     


Lys Ile Asp Lys Ile Leu Asn Gln Thr Asp Arg Ile Asn Ser Phe Tyr 
            740                 745                 750         


Leu Leu Leu Lys Leu Leu Asn Tyr Lys Glu Ile Thr Glu Leu Lys Gly 
        755                 760                 765             


Asn Leu Glu Lys Tyr Gln Ile Leu Ser Lys Thr Asn Val Tyr Glu Lys 
    770                 775                 780                 


Glu Leu Met Leu Leu Asn Ile Val Asn Leu Asp Asn Asn Lys Val Lys 
785                 790                 795                 800 


Ile Glu Asn Phe Lys Ile Ser Ala Glu Glu Ile Gly Lys Phe Ile Glu 
                805                 810                 815     


Lys Ile Asn Ile Glu Glu Ile Asn Lys Lys Ile Lys Thr Phe Glu Glu 
            820                 825                 830         


Leu Arg Asn Phe Glu Lys Gly Glu Asn Thr Gly Glu Tyr Tyr Asn Ile 
        835                 840                 845             


Tyr Ser Asp Asp Lys Asn Ile Lys Asn Ile Arg Asn Leu Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asp Leu Leu Glu Lys Ile Ser Glu Lys Thr 
865                 870                 875                 880 


Asn Tyr Cys Ile Lys Lys Lys Asp Leu Glu Glu Tyr Ser Lys Leu Arg 
                885                 890                 895     


Lys Gln Leu Glu Asp Lys Lys Lys Glu Asn Glu Lys Ile Glu Asp Glu 
            900                 905                 910         


Lys Thr Asn Phe Tyr Lys Ile Gln Glu Tyr Leu His Ser Lys Tyr Gln 
        915                 920                 925             


Gln Glu Pro Lys Lys Ile Leu Trp Lys Asn Asn Lys Asn Asp Tyr Glu 
    930                 935                 940                 


Lys Tyr Lys Lys Ser Ile Glu Asn Ile Glu Lys Tyr Val His Leu Lys 
945                 950                 955                 960 


Asn Lys Ile Glu Phe Asn Glu Leu Asn Leu Leu Gln Ser Leu Leu Leu 
                965                 970                 975     


Lys Ile Leu His Arg Leu Val Gly Phe Thr Ser Ile Trp Glu Arg Asp 
            980                 985                 990         


Leu Arg Phe Arg Leu Thr Gly Glu  Phe Pro Asp Glu Leu  Asp Ile Glu 
        995                 1000                 1005             


Asp Ile  Phe Asp His Arg Lys  Arg Tyr Lys Gly Thr  Gly Gly Gly 
    1010                 1015                 1020             


Ile Cys  Lys Lys Tyr Asp Arg  Phe Ile Asn Thr Tyr  Thr Glu Tyr 
    1025                 1030                 1035             


Lys Asn  Asn Asn Lys Met Lys  Asn Val Lys Phe Ala  Asp Asn Asn 
    1040                 1045                 1050             


Pro Val  Arg Asn Tyr Ile Ala  His Phe Asn Tyr Leu  Pro Asn Pro 
    1055                 1060                 1065             


Lys Tyr  Ser Ile Leu Lys Met  Met Glu Lys Leu Arg  Lys Leu Leu 
    1070                 1075                 1080             


Asp Tyr  Asp Arg Lys Leu Lys  Asn Ala Val Met Lys  Ser Ile Lys 
    1085                 1090                 1095             


Asp Ile  Leu Glu Glu Tyr Gly  Phe Lys Ala Glu Phe  Ile Ile Asn 
    1100                 1105                 1110             


Ser Asp  Lys Glu Ile Ile Leu  Asn Pro Val Lys Ser  Val Glu Ile 
    1115                 1120                 1125             


Ile His  Leu Gly Lys Glu Asp  Leu Lys Ser Arg Arg  Asn Ser Glu 
    1130                 1135                 1140             


Asp Leu  Cys Lys Leu Val Lys  Ala Met Leu Glu Tyr  Ser Glu 
    1145                 1150                 1155         


<210>  1126
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1126

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Lys Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Val Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Phe Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Lys Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Thr Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Cys Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Lys Phe Val Lys Asn Ser Lys Asp Phe Phe Lys Ile Thr Asp Glu Val 
    610                 615                 620                 


Ile Lys Ile Asn Lys Gln Ile Asn Gln Lys Thr Gly Tyr Tyr Lys Tyr 
625                 630                 635                 640 


Gln Lys Phe Glu Asn Ile Glu Lys Thr Val Pro Val Glu Tyr Leu Ala 
                645                 650                 655     


Ile Ile Gln Ser Arg Asp Met Ile Asn Asn Gln Asp Lys Glu Glu Lys 
            660                 665                 670         


Asn Thr Tyr Ile Asp Phe Val Gln Gln Ile Phe Leu Lys Gly Phe Ile 
        675                 680                 685             


Asp Tyr Leu Asn Lys Asn Asn Leu Lys Tyr Ile Glu Asn Asn Asn Asn 
    690                 695                 700                 


Asn Asn Asp Ile Phe Ser Arg Ile Lys Ile Lys Lys Asp Ser Lys Glu 
705                 710                 715                 720 


Arg Tyr Asp Lys Ile Leu Lys Asn Tyr Glu Lys Asn Asn Arg Asn Lys 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Lys Ile Leu Lys Tyr Thr Glu Ser Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Ala Phe Ser Asp Gln Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Leu Lys Glu Leu Lys Glu Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn Tyr Thr Met Gln Gln Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Lys Lys Asp Glu Lys Phe Asn Asp Glu Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asn Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Lys Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Lys  Glu Leu Cys 
    1130                 1135                 1140             


Glu Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Glu  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  1127
<211>  1373
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1127

Met Ala Lys His Leu Arg Pro Ile Gly Glu Ser Tyr Thr Asp Phe Leu 
1               5                   10                  15      


Asp Glu Thr Glu Phe Val Arg Leu Gly Arg Gly Leu His Arg Gly His 
            20                  25                  30          


His Gly Val Gln Ile Pro Pro Thr Glu Leu Pro Ser Tyr Leu Ala Glu 
        35                  40                  45              


Tyr Arg Lys Ala Leu Met Arg Gln Val Val Ala Val Leu Asp Lys Val 
    50                  55                  60                  


Val Gly Lys Arg Arg Arg Leu Ser Gly Met His Pro Glu Ala Tyr Arg 
65                  70                  75                  80  


Asp Arg Val His Leu Ala Glu Ala Leu Trp Val Arg Leu Val Ala Arg 
                85                  90                  95      


Val Lys Glu Ile Gly Thr Pro Pro Asp Pro Ser Glu Leu Leu Asp Leu 
            100                 105                 110         


Arg Arg Met Trp Asn Ala Lys Ala His Pro Tyr Ala Glu Tyr Asp Val 
        115                 120                 125             


Val Pro Arg Ala Pro Leu Asn Asp Gly Asn Gly Gln Lys Ile Leu Glu 
    130                 135                 140                 


Cys Arg Glu Val Asp Asp Pro Lys Ile Glu Arg Ser Asp Phe Glu Gly 
145                 150                 155                 160 


Arg Trp His Gly Arg Phe Trp Gln Ser Glu Pro Gly Pro Val Asp Tyr 
                165                 170                 175     


Asn Ala Ile Ala Asp Arg Ile Phe Ala His Leu Phe Asp Gln Glu Ala 
            180                 185                 190         


Val Ile Gly Gly Gly Pro Arg Arg Glu Gly Asn Val Thr Val Pro Asp 
        195                 200                 205             


Glu Asp Ile Asn Gly Gln Pro Gly Pro Ala Thr Gly Lys Gly Leu Ile 
    210                 215                 220                 


Ile Ala Arg Gly Gln Ser Ile Val Lys Ser Ala Ser Asp Pro Arg Arg 
225                 230                 235                 240 


Ser Ser Lys Lys Val Gln Arg Thr Trp Asp Lys Ala Val Glu Arg Arg 
                245                 250                 255     


Tyr Phe Gly Asp Asp Gly Lys Gly Gly Ser Asp Ile Ala Lys Ala Ile 
            260                 265                 270         


Tyr Glu Glu Leu Gly Asp Pro Ala Thr Leu Ala Asp Pro Ile Tyr Ala 
        275                 280                 285             


Ser Trp Phe Gly Ser Arg Leu Tyr Asp His Phe Gly Ser Phe Lys Asn 
    290                 295                 300                 


Ser Leu Pro Leu Glu Leu Lys Asp Pro Phe Lys Glu Gln Ile Trp Ala 
305                 310                 315                 320 


Leu His Asn Ser Val Arg Gln Phe Tyr Gln Arg Met Ala Lys Ser Asp 
                325                 330                 335     


Arg Phe Arg Leu Ala Leu Gln Asn Ala Arg Ser Glu Val Pro Asp Arg 
            340                 345                 350         


Ser Glu Leu Leu Ala Leu Leu Pro Lys Asp His Asp His Leu Leu Leu 
        355                 360                 365             


Val Leu Gly Gly Lys Lys Lys Asn Ala Glu Met Ser Glu Leu Ile Arg 
    370                 375                 380                 


Leu Gly Lys Leu Phe Val His Ala Ser Asp Val Leu His Asp Phe Asp 
385                 390                 395                 400 


Ala Asn Asp Ala Ala Ala Leu Asp Ala Phe Lys Arg Arg Met Ser Phe 
                405                 410                 415     


Leu Ala Thr Ser Ile Gly Gln Ser Glu Ile Lys Gln Thr Glu Thr Phe 
            420                 425                 430         


Ala Arg Thr Trp Arg Gly Ala Val Gly Leu Thr Leu Arg Thr Val Lys 
        435                 440                 445             


Gly Leu Ala Asp Pro Arg Gly Ile Ile Gly Thr Pro Asp Asn Arg Asp 
    450                 455                 460                 


Leu Gly Thr Ala Gly Pro Met Lys Asp Ala Phe Asn Lys Phe Asp Gln 
465                 470                 475                 480 


Pro His Phe Gln Gln His Met Thr Ile Ile Phe Gly Asn Lys Glu Leu 
                485                 490                 495     


Gln Ala Glu Gly Asn Pro Thr Arg Ser Ser Val Phe Thr Ala Asn Gly 
            500                 505                 510         


Asp Lys Asp His Gln Ala Glu Leu Leu Trp Gly Phe Leu Cys Val Val 
        515                 520                 525             


Arg Ser Val Arg Asn Arg Thr Asn His Tyr Asn Val Arg Arg Ala Leu 
    530                 535                 540                 


Leu Arg Leu Leu Asp Glu Gly Ile Val Ser Pro Met Pro Ser Asp Pro 
545                 550                 555                 560 


Lys Lys Glu Arg Val Glu Asn Arg Asn Leu Cys Thr Val Ser Pro Thr 
                565                 570                 575     


Ala Leu Glu Ala Phe Arg Arg Leu Leu Asn Phe Asp Leu Ala Ile Gln 
            580                 585                 590         


Lys Glu Ala Val Arg Thr Ala Leu Glu Gln Ala Lys Ala Ser Glu Phe 
        595                 600                 605             


Val Glu Glu Gly Lys Leu Arg Gly Leu Val Ser Glu Leu Ala Gly Thr 
    610                 615                 620                 


Glu Asp Met Pro Ala Leu His Ile Pro Arg Phe Ser Ala Val Met Asp 
625                 630                 635                 640 


Lys Val Arg Arg Leu Ala Asp Asn Arg Asp Val Gly Leu Asp Pro Ile 
                645                 650                 655     


Leu Ser Thr Leu Gln Arg Ser Leu Pro Pro Thr Asp Lys Gln Ala Glu 
            660                 665                 670         


Ser Asp Ala Ala Arg Cys Arg Tyr Arg Leu Leu Leu Glu Leu Tyr Lys 
        675                 680                 685             


Ser Gly Phe Arg Ser Trp Phe Ser Gly Ile Gln Ser Asn Glu Glu Asn 
    690                 695                 700                 


Asn Arg Glu Ile Cys His Trp Ala Val Lys Gln Val Gly Arg Ala Lys 
705                 710                 715                 720 


Asp Ala Arg Lys Ser Glu Tyr Asp Lys Lys Thr Lys Arg His Tyr Arg 
                725                 730                 735     


Ser Pro Asn Ser Leu Ile Asp Asp Leu Gly Leu Asp Lys Phe Asp Asp 
            740                 745                 750         


Leu Thr Asp Leu Leu Glu Ala Leu Ala Ser Gln Ser Thr Arg Glu His 
        755                 760                 765             


Asp Gln Asn Leu Lys Tyr Val Pro Asp Ala Arg Val Gln Ser Gln Met 
    770                 775                 780                 


Ser Asn Arg Ile Glu Glu Phe Arg Gln Glu Leu Phe Ala His Ile Phe 
785                 790                 795                 800 


Thr Lys Tyr Leu Asp Thr His Asp Phe Gly Trp Ile Gly Ala Ile Glu 
                805                 810                 815     


Val Arg Arg Glu Ala Cys Asp Leu Ala Asp Val Val Ser Ala Phe Glu 
            820                 825                 830         


Val Arg Asp Gln Lys Phe Asp Ala Asp Trp His Ser Gln Phe Tyr Ala 
        835                 840                 845             


Trp Leu Tyr Met Val Pro Pro Ile Glu Ala Ser Arg Leu Arg His Gln 
    850                 855                 860                 


Met Arg Lys Ser Ala Val Met Asp Asp Lys Trp Ser Thr Thr Leu Glu 
865                 870                 875                 880 


Leu Thr Ser Gly Asp Arg Lys Thr Arg Asp Asp His Ala Gln Asp Val 
                885                 890                 895     


Leu Ala Asp Met Asp Arg Leu Phe Ser Leu Tyr Thr Lys Val Gln Ala 
            900                 905                 910         


Ala Gly Phe Asn Gly Gln Glu His Glu Ser Ala Leu Gly Ser Lys Ser 
        915                 920                 925             


Leu Phe Tyr Glu Asp Gly Asn Gln Phe Asp Glu Val Tyr Ser Pro Asp 
    930                 935                 940                 


Thr Glu Thr His Asn Lys Thr Phe Pro Gly Thr Arg Arg Gly Leu Arg 
945                 950                 955                 960 


Gln Leu Val Arg Tyr Ala His Leu Pro Ala Leu Glu Gly Val Phe Lys 
                965                 970                 975     


Lys His Arg Ile Thr Lys Ala Glu Val Glu Thr Phe Val Ala Leu Tyr 
            980                 985                 990         


Asp Glu Asn Arg Arg Asp Pro Gly  Ser Val Ala His Met  Leu Arg Arg 
        995                 1000                 1005             


Glu Lys  Leu Arg Thr Glu Ile  Leu Arg Ser Ile His  Asp Gly Pro 
    1010                 1015                 1020             


Lys Pro  Lys Asp Lys Asp Phe  Trp Pro Lys Leu Glu  Ala Lys Cys 
    1025                 1030                 1035             


Leu Glu  Tyr Arg Thr Val Ala  Thr Glu Thr Ala Ile  Tyr Asn Phe 
    1040                 1045                 1050             


Gln Ala  Asn Ala Ala Arg Leu  Asn Asp His Ala Arg  Leu His Gln 
    1055                 1060                 1065             


Ile Val  Met Arg Val Val Ala  Arg Leu Thr Asp Tyr  Ala Leu Ile 
    1070                 1075                 1080             


Trp Glu  Arg Asp Arg Leu Phe  Ala Phe Val Gly Met  Leu Tyr Arg 
    1085                 1090                 1095             


Gln Thr  Gly Gly Thr Gly Ile  Asn Pro Ala Met Arg  His Ala Glu 
    1100                 1105                 1110             


Lys Thr  Asn Ala Pro Pro Arg  Ile Gly Ile Leu Val  Ser Asp Ser 
    1115                 1120                 1125             


Ala Leu  Ala Lys Lys Leu Asn  Ser Asn Ser Ala Glu  Val Phe Ile 
    1130                 1135                 1140             


Pro Tyr  Leu Asp Thr Glu Thr  Gly Phe Asp Ala Pro  Arg Phe Asp 
    1145                 1150                 1155             


Asp Leu  Cys Thr Leu Leu Ser  His Glu His Ala Lys  Glu Phe Arg 
    1160                 1165                 1170             


Phe His  Phe Leu Glu Val Gly  Glu Glu Asn Ser Lys  Asp Glu Ala 
    1175                 1180                 1185             


Arg Arg  Leu Asn Glu Glu Thr  Met Gly His Arg Lys  Arg Pro Ala 
    1190                 1195                 1200             


Phe Lys  Arg Gly Thr Arg Arg  Gln Gly Ile Arg Asn  Asp Leu Ala 
    1205                 1210                 1215             


His His  Asn Val Leu Asp Leu  Ala Gly Gly Ala Gly  Pro Asn Leu 
    1220                 1225                 1230             


Thr Tyr  Val Val Asn Ala Val  Arg Ser Leu Leu Ser  Tyr Asp Arg 
    1235                 1240                 1245             


Lys Leu  Lys Asn Ala Val Pro  Lys Ser Ile Lys Arg  Ile Leu Gly 
    1250                 1255                 1260             


Glu Glu  Gly Leu Ile Ile Glu  Trp Gln Met Asn Tyr  Asp Arg Leu 
    1265                 1270                 1275             


Lys Lys  Pro Thr Val Tyr Pro  Asn Val Glu Thr His  Leu Thr Met 
    1280                 1285                 1290             


Val Pro  Pro Arg His Met Thr  Ala Pro Val Ser Phe  Thr Leu Pro 
    1295                 1300                 1305             


Arg Ala  Ser Val Arg Leu Ala  Ser Met Val Lys Ala  Val Phe Asp 
    1310                 1315                 1320             


Phe Gly  Ser Ser Gly Tyr Gly  Glu Glu Arg Met Ile  Gly Gly Arg 
    1325                 1330                 1335             


Thr Ala  Lys Gln Ala Val Tyr  Pro Asp Asp Phe Thr  Arg Arg Phe 
    1340                 1345                 1350             


Pro Gln  Thr Pro Met Gly Leu  Lys Gln Ala Thr Arg  Leu Val Phe 
    1355                 1360                 1365             


Ala Ser  Glu Asn Ser 
    1370             


<210>  1128
<211>  1287
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1128

Met Arg Ile Gly Lys Val Gln Gly Arg Thr Phe Thr Gly Phe Asp Asn 
1               5                   10                  15      


Ala Arg Gly Lys Thr Leu Arg Arg Arg Leu Leu Thr Arg Pro Asp Asn 
            20                  25                  30          


Glu Ala Arg Ser Leu Ser Glu His Leu Ala His Asp Pro Lys Ala Leu 
        35                  40                  45              


Ile Gly Gln Ala Ile Ser Arg Ile Asp Thr Ile Tyr Gln Lys Pro Lys 
    50                  55                  60                  


Thr Gly Lys Pro Thr Pro Glu Gln Phe Gly His Arg Asp Thr Leu Gly 
65                  70                  75                  80  


Trp Ala Tyr Trp Lys Leu Leu Val Ala Ser Tyr Pro Glu Val Glu Gly 
                85                  90                  95      


His Arg Asp Leu Phe Val Arg Arg Leu His Pro Tyr Gly Asp Thr Pro 
            100                 105                 110         


Pro Lys Ser His Gly Gln Lys Glu Gly Glu His Gln Lys Gly Gly Lys 
        115                 120                 125             


Pro Gln Leu Glu Gly Arg Trp His Gly Val Met Ala Gln His Gly Lys 
    130                 135                 140                 


Asn Pro Asp Gln Ile Ala Ala Arg Leu Phe Asp His Leu His Asn Ser 
145                 150                 155                 160 


Glu Leu Arg Phe Gly Gly Thr Ala Ser Gly Glu Pro Arg Thr Arg Pro 
                165                 170                 175     


Gly Lys Glu Ala Thr Pro Thr Gly Leu Ile Gly Ala Arg Ala Lys Thr 
            180                 185                 190         


Ile Glu His Ser Val Leu Pro Arg Asp Ala Lys Arg Phe Val Ala Glu 
        195                 200                 205             


Trp Arg Gly Glu Asp Gln Glu Arg Tyr Ala Gly Ala Arg Asp Ile Ala 
    210                 215                 220                 


Ala Ala Ile Ser Ala Gly Leu Asn Asp Lys Asp Gln Lys Ser Gly Ser 
225                 230                 235                 240 


Gly Arg Lys Ser Ala Val Ile Gly Lys Leu Leu Ser Asp His Leu Glu 
                245                 250                 255     


Thr Leu Thr Gly Asn Arg Lys Cys Arg Phe Asp Pro Lys Ser Thr Ala 
            260                 265                 270         


Glu Thr Leu Glu Leu Arg Asp Gly Glu Ser Val Asp Asp Arg Arg Arg 
        275                 280                 285             


Ile Leu Glu Leu His Ala Glu Val Lys Ala Thr Tyr Lys Arg Met Ala 
    290                 295                 300                 


Ala Trp Lys Pro Ala Lys Leu Pro Arg Asn Ser Asp Glu Leu Phe Arg 
305                 310                 315                 320 


Leu Val Arg Gln Gln Ala Asp Asn Arg Ile Leu Asn His Leu Val Arg 
                325                 330                 335     


Val Gly Arg Ile Ser Val Tyr Ser Glu Gln Ser Asp Ala Leu Ser Glu 
            340                 345                 350         


Ser Gln Phe Trp Thr Ser Gly Gly Gln Thr Gln Ile Lys Glu Ser Glu 
        355                 360                 365             


Val Phe Ala Arg Leu Trp Ile Gly Ala Ile Ser Arg Ala Ser Tyr Ser 
    370                 375                 380                 


Met Lys Ala Trp Leu Glu Pro Glu Gly Thr Val Phe Asn Pro Ser Ile 
385                 390                 395                 400 


Asn Asp Phe Asp Val Thr Ser Ser His Asn Thr Asn Arg Ile Leu Glu 
                405                 410                 415     


Asp Ser Gly Arg Leu Ser Asn Ala Met Ala Arg Arg Ala Ile Tyr Phe 
            420                 425                 430         


Gly Glu Thr Pro Glu Phe Asp Ala Leu Gly Glu Glu Asp Gln Arg Val 
        435                 440                 445             


Leu Val Lys Lys Cys Leu Asp Ala Leu Ser Ala Cys Arg Asn Arg Thr 
    450                 455                 460                 


Phe His His Gly Gln Arg Ala Lys Phe Leu Lys Glu Val Arg Lys Gly 
465                 470                 475                 480 


Leu Lys Glu Lys Glu Ala Asp Ser Ala Gly Pro Ala Ala Trp Glu Gly 
                485                 490                 495     


Ile Arg Glu Val Ile Gln Ala Asp Ala Arg Asn Leu Gly Ala Arg Leu 
            500                 505                 510         


Leu Gln Asp Leu Thr Gly Ala Lys Val His Ser Phe Ala Thr Asp Pro 
        515                 520                 525             


Glu Phe Arg His Leu Tyr Glu Ser Val Ala Ala Thr Leu Thr Ala Gly 
    530                 535                 540                 


Gly Glu Leu Glu Ala Ala Leu Pro Arg Leu Lys Asn Val Leu Lys Arg 
545                 550                 555                 560 


Ala Glu Gly Val Arg Cys Tyr Leu Asp Thr Pro Ser Gln Arg Arg Glu 
                565                 570                 575     


Gly Asp Glu Ser Leu Ile Ala Arg Leu Pro Val Ala Pro Val Pro Arg 
            580                 585                 590         


Glu Leu Asp Asp Ala Ala Thr Lys Ala Arg His Ser Ala Leu Leu Arg 
        595                 600                 605             


Leu Tyr Asp Gly Pro Phe Arg Pro Trp Ala Thr Glu Leu Arg Gly Glu 
    610                 615                 620                 


Arg Leu Ser Asp Tyr Ala Ala Arg Ala Lys Arg Leu Ala Thr Arg Leu 
625                 630                 635                 640 


Ala Lys Ser Thr Asn Thr Ala Ser Pro Tyr Pro Asp Ser Val Glu Gly 
                645                 650                 655     


Arg Ser Val Arg Leu Arg Asp Pro Ile Thr Ala Asp Thr Ala Pro Glu 
            660                 665                 670         


Thr Leu Lys Thr Tyr Leu Ser Ala Leu Thr Ala Glu Thr Ala Thr Glu 
        675                 680                 685             


Phe Arg Val Gln Lys Gly Tyr Glu Ser Asp Gly Glu Lys Ala Lys Glu 
    690                 695                 700                 


Gln Ala Glu Phe Ile Glu Asp Phe Arg Arg Asp Met Ile Ala Leu Ala 
705                 710                 715                 720 


Phe Gln Asp Phe Ile Arg Asp His Gly Phe Ala Trp Leu Leu Asp Ile 
                725                 730                 735     


Ala Ser Lys Ala Glu Pro Ser Asn Asp Ala Pro Asn Leu Pro Asp Pro 
            740                 745                 750         


Val Asp Thr Gly Lys Asp Thr Val Phe Glu Asp Trp Gln Ala Leu Leu 
        755                 760                 765             


Tyr Leu Phe Leu His Phe Val Pro Ala Asp Asp Val Ser Gln Leu Leu 
    770                 775                 780                 


His Gln Leu Arg Lys Trp Asp Ala Leu Gln Asp Lys Tyr Glu Leu Ala 
785                 790                 795                 800 


Glu Pro Gly Glu Thr Leu Gly Gln Thr Lys Ala Asp Thr Arg Lys Ile 
                805                 810                 815     


Val Gly Gln Phe Arg Asp Cys Leu Thr Leu Phe Leu Lys Thr Gly Asp 
            820                 825                 830         


Ala Arg Phe Asp Gly Glu Gly Val Glu Leu Pro Leu Ser Asp Phe Gln 
        835                 840                 845             


Glu Leu Phe Glu Ser Pro Ala Thr Phe Lys Glu Leu Phe Leu Ala Glu 
    850                 855                 860                 


Pro Ala Glu Asn Asp Ala Ser Glu Thr Asp Asp Gln Asp Ala Pro Gly 
865                 870                 875                 880 


Glu Lys His Arg Val Thr Arg Thr Arg Arg Gly Leu Arg Gln Ile Leu 
                885                 890                 895     


Arg Tyr Asn His Met Pro Val Leu Arg Asp Leu Phe Leu Ala His Lys 
            900                 905                 910         


Val Thr Asp Ala Glu Val Asp Gly Leu Gln Ala Leu Glu Val Asp Asp 
        915                 920                 925             


Pro Gln Thr Gly Glu Ser Gln Ile Gly Ala Ala Gln Arg Ile Arg Thr 
    930                 935                 940                 


Glu Ile His His His Thr Ser Asn Asp Lys Gln Ile Ser Glu Ala Lys 
945                 950                 955                 960 


Val Glu Glu Tyr Arg Arg Ala Leu Ser Thr Ile Glu Arg His Arg Phe 
                965                 970                 975     


Leu Val Gly Arg Val Tyr Leu Gly Asp His Ile Arg Val His Lys Leu 
            980                 985                 990         


Met Met Asp Val Met Gly Arg Leu  Val Asp Phe Ala Gly  Ala Trp Glu 
        995                 1000                 1005             


Arg Glu  Ala Ala Asp Gly Asp  Arg Lys Gly Phe Ile  Ser Arg Ala 
    1010                 1015                 1020             


Ile Ala  Leu Pro Glu Val Ala  Glu Gly Tyr Ala Ala  Asp Arg Leu 
    1025                 1030                 1035             


Lys Thr  Val Ala Arg Arg Val  Leu Asp Asp Gly Glu  Ala Arg Arg 
    1040                 1045                 1050             


Ile Arg  Asn Asp Leu Gly His  Phe Asn Asp Leu Ala  Pro Thr Ser 
    1055                 1060                 1065             


Gly Pro  Ala Asn Leu Thr Phe  Val Val Asn Arg Ala  Arg Arg Met 
    1070                 1075                 1080             


Met Arg  His Asp Arg Lys Arg  Lys Asn Ala Val Thr  Lys Ser Val 
    1085                 1090                 1095             


Ile Glu  Ile Leu Asn Arg Gln  Gly Leu Gly Ile Glu  Trp Thr Met 
    1100                 1105                 1110             


Arg Asn  His Glu Leu Cys Glu  Ala Lys Leu Trp Gln  Asn Pro Val 
    1115                 1120                 1125             


Lys His  Leu Gly Phe Ala Thr  Leu Glu Gly Arg Gly  Lys Lys Trp 
    1130                 1135                 1140             


Arg Arg  Pro Phe Glu Ala Arg  Tyr Gly Asp Ala Tyr  Met Ala Met 
    1145                 1150                 1155             


Val Ala  Gln Leu Phe Asp Gly  Thr Val Thr Ser Pro  Pro Ala Lys 
    1160                 1165                 1170             


Gly Pro  Pro Gln Ser Gly Lys  Ser Gly Gly Lys Pro  Gly Lys Gly 
    1175                 1180                 1185             


Ala Glu  Gly Gly Ala Lys Glu  Lys Ser Arg Ser Pro  Thr Arg Met 
    1190                 1195                 1200             


Glu Glu  Gly Gly Val Tyr Glu  Gly Arg Val Ala Lys  Ala Lys Ser 
    1205                 1210                 1215             


Asp Lys  Gly Phe Gly Phe Leu  Leu Val Glu Gly Ala  Gln Glu Glu 
    1220                 1225                 1230             


Ile Phe  Leu His Ile Tyr Gly  Ile Ser Gly Asn Arg  Pro Ala Arg 
    1235                 1240                 1245             


Ile Glu  Asn Gly Gln Arg Tyr  Arg Phe Thr Leu Gly  Ile Asp Arg 
    1250                 1255                 1260             


Asp Arg  Glu Arg Arg Lys Glu  Arg Ala Trp Val Ala  Arg Glu Ala 
    1265                 1270                 1275             


Val Arg  Ile Asp Glu Asn Arg  Ser Lys 
    1280                 1285         


<210>  1129
<211>  1065
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1129

Leu Leu Phe Leu Trp Ile Ile Glu Glu Val Ile Tyr Glu Ile Ile Lys 
1               5                   10                  15      


Leu Tyr Lys Asn Leu Lys Glu Glu Ile Ile Met Gly Asn Leu Phe Gly 
            20                  25                  30          


Tyr Lys Arg Trp Tyr Glu Val Arg Asp Lys Glu Asp Tyr Lys Ile Lys 
        35                  40                  45              


Arg Lys Val Lys Val Lys Arg Asn Tyr Asp Gly Asn Lys Tyr Ile Leu 
    50                  55                  60                  


Asn Ile Asn Glu Asn Asn Asn Lys Glu Lys Ile Asn Asp Asn Lys Phe 
65                  70                  75                  80  


Ile Arg Glu Phe Val Asn Tyr Lys Lys Asn Asp Asn Val Leu Ile Glu 
                85                  90                  95      


Phe Lys Arg Lys Phe His Ala Gly Asn Ile Leu Phe Lys Leu Lys Gly 
            100                 105                 110         


Lys Glu Arg Ile Lys Arg Ile Glu Asn Asp Asp Asp Phe Leu Lys Thr 
        115                 120                 125             


Glu Glu Val Val Leu Tyr Ile Glu Val Tyr Gly Lys Ser Glu Lys Leu 
    130                 135                 140                 


Lys Ala Leu Gly Ile Thr Lys Lys Lys Ile Ile Asp Glu Ala Ile Lys 
145                 150                 155                 160 


Gln Gly Ile Thr Lys Asp Asp Lys Lys Ile Glu Ile Lys Arg Gln Lys 
                165                 170                 175     


Ile Glu Ile Asn Ile Arg Asp Lys Cys Thr Asn Lys Thr Val Asp Asp 
            180                 185                 190         


Cys Ser Val Ile Leu Arg Ile Ile Glu Asn Asp Glu Leu Glu Thr Lys 
        195                 200                 205             


Lys Ser Ile Tyr Glu Ile Phe Lys Asn Ile Asn Met Asn Leu Tyr Lys 
    210                 215                 220                 


Ile Ile Glu Lys Ile Ile Val Asn Lys Thr Glu Lys Val Phe Glu Asn 
225                 230                 235                 240 


Arg Tyr Tyr Lys Glu Tyr Leu Lys Glu Lys Leu Leu Glu Asp Asn Gln 
                245                 250                 255     


Ile Asn Ile Ile Leu Thr Asn Phe Met Lys Ile Arg Glu Lys Ile Glu 
            260                 265                 270         


Ser Asn Pro Glu Ile Met Gly Phe Val Lys Phe Tyr Phe Asn Val Gly 
        275                 280                 285             


Gly Asp Lys Lys Lys Ser Glu Asn Lys Lys Met Leu Val Glu Lys Ile 
    290                 295                 300                 


Leu Asn Ile Asn Val Asp Leu Thr Val Glu Asp Ile Val Asp Phe Ile 
305                 310                 315                 320 


Val Lys Glu Leu Lys Phe Trp Asp Ile Thr Lys Arg Ile Glu Lys Leu 
                325                 330                 335     


Gln Glu Lys Thr Val Asn Arg Thr Asp Glu Asp Ile Lys Lys Thr Tyr 
            340                 345                 350         


Ile Asn Thr Tyr Val Ser Leu Asp Lys His Glu Lys Phe Lys Lys Tyr 
        355                 360                 365             


Asn Arg Asn Lys Lys Asp Thr Ile Val Lys Ser Phe Ile Lys Asp Ile 
    370                 375                 380                 


Lys Asp Asn Thr Met Lys Gln Lys Ile Asn Gln Ile Leu Arg Lys Phe 
385                 390                 395                 400 


Lys Ile Glu Glu Leu Ile Glu Lys Leu Arg Ile Glu Asn Lys Asn Phe 
                405                 410                 415     


Asp Thr Glu Ile Phe Arg Ile Phe Lys Asp His Tyr Gln Glu Met Phe 
            420                 425                 430         


Ser Ser Glu Lys Phe Glu Glu Lys Ser Asp Glu Glu Lys Glu Leu Tyr 
        435                 440                 445             


Lys Ile Ile Tyr Arg Tyr Leu Lys Gly Arg Ile Glu Lys Ile Leu Ile 
    450                 455                 460                 


Asn Gly Glu Lys Val Arg Leu Lys Lys Met Glu Lys Ile Glu Ile Glu 
465                 470                 475                 480 


Lys Ile Leu Asn Glu Ser Ile Leu Ser Glu Lys Ile Leu Lys Arg Ile 
                485                 490                 495     


Lys Gln Tyr Thr Leu Glu His Ile Met Tyr Leu Gly Lys Leu Arg His 
            500                 505                 510         


Asn Asp Ile Val Lys Met Thr Val Asn Thr Asn Asp Phe Ser Arg Leu 
        515                 520                 525             


His Ala Lys Glu Glu Leu Asp Leu Glu Leu Ile Thr Phe Phe Ala Ser 
    530                 535                 540                 


Thr Asn Met Glu Leu Asn Lys Ile Phe Asn Gly Lys Glu Lys Ile Thr 
545                 550                 555                 560 


Asp Phe Phe Gly Phe Asn Leu Asn Gly Gln Lys Ile Thr Leu Lys Glu 
                565                 570                 575     


Lys Val Pro Ser Phe Lys Leu Asn Ile Leu Lys Lys Leu Asn Phe Ile 
            580                 585                 590         


Asn Asn Glu Asn Asn Ile Asp Glu Lys Leu Ser His Phe Tyr Ser Phe 
        595                 600                 605             


Gln Lys Glu Gly Tyr Leu Leu Arg Asn Lys Ile Leu His Asn Ser Tyr 
    610                 615                 620                 


Gly Asn Ile Gln Glu Thr Ile Asn Leu Lys Gly Glu Tyr Glu Asn Ile 
625                 630                 635                 640 


Glu Asn Leu Ile Lys Glu Leu Lys Val Asn Asn Glu Glu Ile Ser Lys 
                645                 650                 655     


Ser Leu Asn Leu Asp Ile Ile Phe Glu Gly Lys Val Asp Ile Ile Asn 
            660                 665                 670         


Lys Ile Asn Ser Leu Glu Ile Gly Glu Tyr Lys Asp Lys Lys Tyr Leu 
        675                 680                 685             


Pro Ser Phe Ser Lys Ile Val Pro Glu Ile Thr Arg Lys Phe Arg Glu 
    690                 695                 700                 


Ile Asn Lys Asp Lys Ser Phe Asp Ile Glu Ser Glu Lys Ile Ile Leu 
705                 710                 715                 720 


Asn Ala Val Gln Tyr Val Asn Lys Ile Leu Tyr Glu Lys Ile Thr Ser 
                725                 730                 735     


Asn Glu Glu Asn Glu Phe Ile Lys Thr Leu Pro Asp Lys Leu Val Lys 
            740                 745                 750         


Lys Asn Asn Asn Lys Glu Asn Lys Asn Ser Leu Ser Ile Glu Glu Tyr 
        755                 760                 765             


Tyr Lys Asn Ala Gln Val Ser Ser Ser Lys Gly Asp Lys Lys Ala Ile 
    770                 775                 780                 


Lys Lys Tyr Gln Asn Lys Val Thr Asn Ala Tyr Ile Glu Tyr Leu Glu 
785                 790                 795                 800 


Asn Thr Phe Ala Glu Val Ile Asn Phe Ser Asn Phe Asn Leu Asn Phe 
                805                 810                 815     


Asp Glu Ile Lys Thr Lys Ile Glu Glu Arg Lys Asp Ser Lys Asn Lys 
            820                 825                 830         


Ile Val Ile Asp Ser Ile Ser Thr Asn Ile Asn Ile Thr Asn Asp Thr 
        835                 840                 845             


Glu Tyr Ile Ile Ser Ile Phe Ala Leu Leu Asn Asn Asn Thr Tyr Ile 
    850                 855                 860                 


Asn Lys Ile Arg Asn Arg Phe Phe Ala Thr Ser Val Trp Leu Glu Lys 
865                 870                 875                 880 


Gln Asn Ser Thr Lys Glu Tyr Asp Tyr Glu Asn Ile Ile Ser Ile Leu 
                885                 890                 895     


Asp Glu Ile Ile Gln Leu Asn Thr Leu Arg Asn Glu Cys Ile Ile Glu 
            900                 905                 910         


Asn Trp Asn Ser Asn Leu Lys Glu Phe Ile Gln Lys Met Leu Asp Val 
        915                 920                 925             


Glu Lys Glu Ile Gly Asn Phe Glu Ile Lys Thr Lys Lys Glu Ile Phe 
    930                 935                 940                 


Glu Ile His Tyr Glu Glu Ile Lys Lys Asp Met Ile Val Lys Ile Asn 
945                 950                 955                 960 


Asp Asn Lys Ile Gln Lys Ile Leu Asn Lys Tyr Leu Lys Glu Ile Thr 
                965                 970                 975     


Gly Phe Ser Ser Asn Asn Glu Tyr Met Phe Lys Asn Leu Gly Lys Leu 
            980                 985                 990         


Thr Leu Glu Glu Arg Asp Phe Ile  Leu Pro Asn Lys Lys  Leu Ile Glu 
        995                 1000                 1005             


Lys Asn  Ile Asp Glu Ile Ile  Gly Glu Lys Leu Asp  Ala Ile Lys 
    1010                 1015                 1020             


Glu Lys  Ile Leu Leu Arg Lys  Val Phe Ser Ser Lys  Phe Leu Glu 
    1025                 1030                 1035             


Lys Tyr  Lys Lys Glu Ile Asp  Asn Leu Ile Glu Asp  Thr Glu Ser 
    1040                 1045                 1050             


Glu Asn  Lys Asn Lys Phe Glu  Lys Ile Tyr Tyr Pro  
    1055                 1060                 1065 


<210>  1130
<211>  1157
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1130

Met Leu Arg Arg Met Cys Met Lys Ile Thr Lys Ile Asp Gly Ile Ser 
1               5                   10                  15      


His Lys Lys Tyr Lys Glu Lys Gly Lys Leu Ile Lys Ser Asn Glu Ile 
            20                  25                  30          


Glu Lys Asp Ile Thr Glu Glu Arg Phe Asn Asp Ile Glu Ala Lys Thr 
        35                  40                  45              


Thr Glu Leu Phe Gln Lys Thr Leu Asp Phe Tyr Val Lys Asn Tyr Glu 
    50                  55                  60                  


Asn Ser Glu Asp Gln Asn Lys Glu Arg Arg Glu Lys Ala Lys Asn Tyr 
65                  70                  75                  80  


Phe Ser Lys Val Lys Ile Leu Val Asp Asn Lys Lys Ile Thr Ile Cys 
                85                  90                  95      


Asn Glu Asn Thr Glu Lys Met Glu Ile Glu Asp Phe Asn Glu Tyr Asp 
            100                 105                 110         


Val Arg Ser Gly Lys Tyr Phe Asn Val Leu Asn Lys Ile Leu Asn Gly 
        115                 120                 125             


Glu Asn Tyr Thr Glu Glu Asp Leu Glu Val Phe Glu Asn Asp Leu Gln 
    130                 135                 140                 


Lys Arg Ile Gly Arg Ile Lys Ser Ile Lys Asn Ser Leu Glu Glu Asn 
145                 150                 155                 160 


Lys Ala His Phe Lys Lys Glu Ser Ile Asn Asn Asn Ile Ile Tyr Asp 
                165                 170                 175     


Arg Val Lys Gly Asn Asn Lys Lys Ser Leu Phe Tyr Glu Tyr Tyr Arg 
            180                 185                 190         


Ile Ser Ser Lys His Gln Glu Tyr Val Asn Asn Ile Phe Glu Ala Phe 
        195                 200                 205             


Asp Lys Leu Tyr Ser Asn Ser His Glu Ala Met Asn Asn Leu Phe Ser 
    210                 215                 220                 


Glu Ile Thr Lys Asp Ser Lys Glu Arg Asn Ile Arg Lys Thr Arg Glu 
225                 230                 235                 240 


Ala Tyr His Glu Ile Leu Asn Lys Asn Lys Thr Glu Phe Gly Glu Glu 
                245                 250                 255     


Leu Tyr Lys Lys Ile Gln Asp Asn Ile Ser Asn Phe Asp Lys Leu Leu 
            260                 265                 270         


Glu Ile Glu Pro Glu Ile Lys Glu Leu Thr Lys Ser Gln Ile Phe Tyr 
        275                 280                 285             


Lys Tyr Tyr Ile Asp Lys Val Asn Leu Asp Glu Thr Thr Ile Lys His 
    290                 295                 300                 


Cys Phe Cys His Leu Val Glu Ile Glu Val Asn Gln Leu Leu Lys Asn 
305                 310                 315                 320 


Tyr Val Tyr Ser Lys Arg Asn Ile Asn Lys Glu Lys Leu Glu Asn Ile 
                325                 330                 335     


Phe Glu Tyr Cys Lys Leu Lys Asn Leu Val Lys Asn Lys Leu Val Asn 
            340                 345                 350         


Lys Leu Asn Asn Tyr Ile Arg Asn Cys Gly Lys Tyr Asn Ala Tyr Ile 
        355                 360                 365             


Ser Asn Asn Asp Val Val Val Asn Ser Glu Lys Ile Ser Glu Ile Arg 
    370                 375                 380                 


Thr Lys Glu Ala Phe Leu Arg Ser Ile Ile Gly Val Ser Ser Ser Ala 
385                 390                 395                 400 


Tyr Phe Ser Leu Arg Asn Ile Leu Asn Thr Asp Asn Thr Gln Asp Ile 
                405                 410                 415     


Thr Asn Lys Val Asp Lys Glu Val Asp Lys Leu Tyr Gln Glu Asn Lys 
            420                 425                 430         


Lys Ile Glu Leu Glu Glu Arg Leu Lys Leu Phe Phe Gly Asn Tyr Phe 
        435                 440                 445             


Asp Ile Asn Asn Gln Gln Glu Ile Lys Val Phe Leu Met Asn Ile Asp 
    450                 455                 460                 


Lys Ile Ile Ser Ser Ile Arg His Glu Ile Ile His Phe Lys Met Glu 
465                 470                 475                 480 


Thr Asn Ala Gln Asn Ile Phe Asp Phe Asn Asn Val Asn Leu Gly Asn 
                485                 490                 495     


Thr Ala Lys Asn Ile Phe Ser Asn Glu Ile Asn Glu Glu Lys Ile Lys 
            500                 505                 510         


Phe Lys Ile Phe Lys Gln Leu Asn Ser Ala Asn Ile Phe Asp Tyr Leu 
        515                 520                 525             


Ser Asn Lys Asp Ile Thr Glu Tyr Met Asp Lys Val Val Phe Ser Phe 
    530                 535                 540                 


Thr Asn Arg Asn Val Ser Phe Val Pro Ser Phe Thr Lys Ile Tyr Asn 
545                 550                 555                 560 


Arg Val Gln Asp Leu Ala Asn Ser Leu Glu Ile Lys Glu Trp Lys Ile 
                565                 570                 575     


Pro Asp Glu Ser Glu Gly Lys Asp Ala Gln Ile Tyr Leu Leu Lys Asn 
            580                 585                 590         


Ile Tyr Tyr Gly Lys Phe Leu Asp Lys Phe Leu Asn Glu Glu Asn Gly 
        595                 600                 605             


Ile Phe Ile Ser Ile Lys Asp Lys Ile Ile Glu Leu Asn Arg Asn Gln 
    610                 615                 620                 


Asn Lys Arg Thr Gly Phe Tyr Lys Leu Glu Lys Phe Glu Lys Ile Glu 
625                 630                 635                 640 


Glu Thr Asn Pro Lys Lys Tyr Leu Glu Ile Ile Gln Ser Leu Tyr Met 
                645                 650                 655     


Ile Asn Ile Glu Glu Ile Asp Ser Glu Gly Lys Asn Ile Phe Leu Asp 
            660                 665                 670         


Phe Ile Gln Lys Ile Phe Leu Lys Gly Phe Phe Glu Phe Ile Lys Asn 
        675                 680                 685             


Asp Tyr Asn Tyr Leu Leu Glu Leu Lys Lys Val Gln Asp Lys Lys Asn 
    690                 695                 700                 


Ile Phe Asp Ser Lys Met Ser Glu Tyr Ile Ala Gly Glu Lys Thr Leu 
705                 710                 715                 720 


Glu Asp Ile Gly Glu Ile Asn Glu Ile Ile Gln Lys Ile Glu Ile Thr 
                725                 730                 735     


Lys Ile Asp Lys Ile Leu Asn Gln Thr Asp Arg Ile Asn Ser Phe Tyr 
            740                 745                 750         


Leu Leu Leu Lys Leu Leu Asn Tyr Lys Glu Ile Thr Glu Leu Lys Gly 
        755                 760                 765             


Asn Leu Glu Lys Tyr Gln Ile Leu Ser Lys Thr Asn Val Tyr Glu Lys 
    770                 775                 780                 


Glu Leu Met Leu Leu Asn Ile Val Asn Leu Asp Asn Asn Lys Val Lys 
785                 790                 795                 800 


Ile Glu Asn Phe Lys Ile Ser Ala Glu Glu Ile Gly Lys Phe Ile Glu 
                805                 810                 815     


Lys Ile Asn Ile Glu Glu Ile Asn Lys Lys Ile Lys Thr Phe Glu Glu 
            820                 825                 830         


Leu Arg Asn Phe Glu Lys Gly Glu Asn Thr Gly Glu Tyr Tyr Asn Ile 
        835                 840                 845             


Tyr Ser Asp Asp Lys Asn Ile Lys Asn Ile Arg Asn Leu Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asp Leu Leu Glu Lys Ile Ser Glu Lys Thr 
865                 870                 875                 880 


Asn Tyr Cys Ile Lys Lys Lys Asp Leu Glu Glu Tyr Ser Lys Leu Arg 
                885                 890                 895     


Lys Gln Leu Glu Asp Lys Lys Lys Glu Asn Glu Lys Ile Glu Asp Glu 
            900                 905                 910         


Lys Thr Asn Phe Tyr Lys Ile Gln Glu Tyr Leu His Ser Lys Tyr Gln 
        915                 920                 925             


Gln Glu Pro Lys Lys Ile Leu Trp Lys Asn Asn Lys Asn Asp Tyr Glu 
    930                 935                 940                 


Lys Tyr Lys Lys Ser Ile Glu Asn Ile Glu Lys Tyr Val His Leu Lys 
945                 950                 955                 960 


Asn Lys Ile Glu Phe Asn Glu Leu Asn Leu Leu Gln Ser Leu Leu Leu 
                965                 970                 975     


Lys Ile Leu His Arg Leu Val Gly Phe Thr Ser Ile Trp Glu Arg Asp 
            980                 985                 990         


Leu Arg Phe Arg Leu Thr Gly Glu  Phe Pro Asp Glu Leu  Asp Ile Glu 
        995                 1000                 1005             


Asp Ile  Phe Asp His Arg Lys  Arg Tyr Lys Gly Thr  Gly Gly Gly 
    1010                 1015                 1020             


Ile Cys  Lys Lys Tyr Asp Arg  Phe Ile Asn Thr Tyr  Thr Glu Tyr 
    1025                 1030                 1035             


Lys Asn  Asn Asn Lys Met Lys  Asn Val Lys Phe Ala  Asp Asn Asn 
    1040                 1045                 1050             


Pro Val  Arg Asn Tyr Ile Ala  His Phe Asn Tyr Leu  Pro Asn Pro 
    1055                 1060                 1065             


Lys Tyr  Ser Ile Leu Lys Met  Met Glu Lys Leu Arg  Lys Leu Leu 
    1070                 1075                 1080             


Asp Tyr  Asp Arg Lys Leu Lys  Asn Ala Val Met Lys  Ser Ile Lys 
    1085                 1090                 1095             


Asp Ile  Leu Glu Glu Tyr Gly  Phe Lys Ala Glu Phe  Ile Ile Asn 
    1100                 1105                 1110             


Ser Asp  Lys Glu Ile Ile Leu  Asn Pro Val Lys Ser  Val Glu Ile 
    1115                 1120                 1125             


Ile His  Leu Gly Lys Glu Asp  Leu Lys Ser Arg Arg  Asn Ser Glu 
    1130                 1135                 1140             


Asp Leu  Cys Lys Leu Val Lys  Ala Met Leu Glu Tyr  Ser Glu 
    1145                 1150                 1155         


<210>  1131
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1131

Met Lys Ile Thr Lys Ile Asp Gly Ile Ser His Lys Lys Tyr Ile Lys 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Lys Thr Asp Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Thr Ile Arg Leu Asp Thr Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Glu Phe Phe Ser Asn Lys Val Leu Tyr Leu Lys Asp Gly Ile Leu 
65                  70                  75                  80  


Tyr Leu Lys Asp Arg Arg Glu Lys Asn Gln Leu Gln Asn Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Leu Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Gly Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Lys Asp Asp Ile Thr Gly Lys Met Arg Gly Lys Thr Arg Ile Asp Ser 
                405                 410                 415     


Lys Thr Gly Glu Glu Lys Tyr Ile Pro Gly Glu Val Asp Gln Ile Tyr 
            420                 425                 430         


Tyr Glu Asn Lys Gln Asn Glu Val Lys Asn Lys Leu Lys Met Phe Tyr 
        435                 440                 445             


Gly Tyr Asp Phe Asp Met Asp Asn Lys Lys Glu Ile Glu Asp Phe Phe 
    450                 455                 460                 


Ala Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His 
465                 470                 475                 480 


Phe Asn Leu Asp Leu Asp Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile 
                485                 490                 495     


Val Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu 
            500                 505                 510         


Lys Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val 
        515                 520                 525             


Phe Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr 
    530                 535                 540                 


Arg Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr 
545                 550                 555                 560 


Lys Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr 
                565                 570                 575     


Trp Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile 
            580                 585                 590         


Asp Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu 
        595                 600                 605             


Asn Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu 
    610                 615                 620                 


Ile Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe 
625                 630                 635                 640 


Tyr Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Lys 
                645                 650                 655     


Tyr Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln 
            660                 665                 670         


Asp Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe 
        675                 680                 685             


Leu Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu 
    690                 695                 700                 


Met Tyr Ile Gly Asn Asp Glu Gln Ile Asn Thr Ser Leu Ala Gly Lys 
705                 710                 715                 720 


Lys Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn 
                725                 730                 735     


Ile Glu Ile Pro His Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu 
            740                 745                 750         


Gly Lys Ile Leu Lys Tyr Thr Glu Ser Leu Asn Met Phe Tyr Leu Ile 
        755                 760                 765             


Leu Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu 
    770                 775                 780                 


Glu Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu 
785                 790                 795                 800 


Glu Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp 
                805                 810                 815     


Phe Glu Leu Glu Ala Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly 
            820                 825                 830         


Asn Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Lys Lys 
        835                 840                 845             


Ile Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn 
    850                 855                 860                 


Ile Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys 
865                 870                 875                 880 


Ala Lys Tyr Lys Ile Ser Leu Lys Glu Leu Lys Glu Tyr Ser Asn Lys 
                885                 890                 895     


Lys Asn Glu Ile Glu Lys Asn Tyr Thr Met Gln Gln Asn Leu His Arg 
            900                 905                 910         


Lys Tyr Ala Arg Pro Lys Lys Asp Glu Lys Phe Asn Asp Glu Asp Tyr 
        915                 920                 925             


Lys Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu 
    930                 935                 940                 


Lys Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu 
945                 950                 955                 960 


Leu Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg 
                965                 970                 975     


Asp Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile 
            980                 985                 990         


Glu Glu Ile Phe Asn Phe Asp Asn  Ser Lys Asn Val Lys  Tyr Lys Ser 
        995                 1000                 1005             


Gly Gln  Ile Val Glu Lys Tyr  Ile Asn Phe Tyr Lys  Glu Leu Tyr 
    1010                 1015                 1020             


Lys Asp  Asn Val Glu Lys Arg  Ser Ile Tyr Ser Asp  Lys Lys Val 
    1025                 1030                 1035             


Lys Lys  Leu Lys Gln Glu Lys  Lys Asp Leu Tyr Ile  Arg Asn Tyr 
    1040                 1045                 1050             


Ile Ala  His Phe Asn Tyr Ile  Pro His Ala Glu Ile  Ser Leu Leu 
    1055                 1060                 1065             


Glu Val  Leu Glu Asn Leu Arg  Lys Leu Leu Ser Tyr  Asp Arg Lys 
    1070                 1075                 1080             


Leu Lys  Asn Ala Ile Met Lys  Ser Val Val Asp Ile  Leu Lys Glu 
    1085                 1090                 1095             


Tyr Gly  Phe Val Ala Thr Phe  Lys Ile Gly Ala Asp  Lys Lys Ile 
    1100                 1105                 1110             


Gly Ile  Gln Thr Leu Glu Ser  Glu Lys Ile Val His  Leu Lys Asn 
    1115                 1120                 1125             


Leu Lys  Lys Lys Lys Leu Met  Thr Asp Arg Asn Ser  Glu Glu Leu 
    1130                 1135                 1140             


Cys Lys  Leu Val Lys Val Met  Phe Glu Tyr Lys Met  Glu Glu Lys 
    1145                 1150                 1155             


Asn Leu  Lys Thr Lys Lys Cys  Lys Val Ile 
    1160                 1165             


<210>  1132
<211>  1175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1132

Met Leu Ser Asn Ala Glu His Pro Lys Lys Arg Phe Val Val Asp Phe 
1               5                   10                  15      


Ile Lys Arg Tyr Ala Asn Leu Glu Arg Thr Ala Gln Val Glu Glu Leu 
            20                  25                  30          


Leu His Ile Lys Lys Leu Met Val Met Phe Val Tyr Gly Glu Lys Glu 
        35                  40                  45              


Pro Glu Phe Tyr Asn Lys Glu Asn Pro Tyr Lys Arg Leu Asp Glu Thr 
    50                  55                  60                  


Asp Glu Arg Ile Phe Cys Glu Asp Ala Lys Asn Ile Leu Glu Gln Ile 
65                  70                  75                  80  


Glu Gln Asn Ser Asn Asn Gly Lys Trp Lys Asp Asn Lys Lys Leu His 
                85                  90                  95      


Ile Gln Leu Gly Glu Ser Phe Arg Lys Glu Leu Phe Lys Arg Tyr Lys 
            100                 105                 110         


Gln Met Glu Asp Trp Leu Ser Glu Gln Tyr Lys Val Glu Lys Asp Gly 
        115                 120                 125             


Leu Ile Ala Asn Lys Gly Tyr Asp Leu Thr Asn Lys Asn Leu Met Arg 
    130                 135                 140                 


Ala Lys Glu Asp Leu Tyr Trp Ile Ile Ile Phe Glu Glu Asn Ile Glu 
145                 150                 155                 160 


Ser Tyr Phe Lys Arg Trp Asn Lys Arg Ser Leu Lys Asn Cys Arg Cys 
                165                 170                 175     


Ser Trp Ile Val Asn Arg Leu Trp Asn Glu Trp Asn Ser Leu Ile Cys 
            180                 185                 190         


Met Lys Tyr Ile Asp Leu Gly Lys Ala Val Phe Asn Phe Ala Met Pro 
        195                 200                 205             


Asp Leu His Asp Leu Ser Asp Gly Glu Ile Lys Leu Gly Thr Val Leu 
    210                 215                 220                 


Pro Glu Tyr Gln Glu Gly Ile Thr Ser Phe Asp Tyr Glu Met Val Lys 
225                 230                 235                 240 


Ala Lys Glu Asn Ile Thr Arg Asp Ile Ala Thr Ser Ile Val Phe Ala 
                245                 250                 255     


Ala Asn Thr Phe Ser Asn Ala Val Ile Lys Arg Glu Tyr Arg Glu Gln 
            260                 265                 270         


Pro Asp Lys Asn Ile Arg Asn Asp Val Leu Val Tyr Asp Glu Glu Val 
        275                 280                 285             


Phe Gln Asn Arg Glu Ala Val Gln Glu Asn Ala Phe Lys His Ile Phe 
    290                 295                 300                 


Gln Tyr Phe Gly Gly Ala Ser Thr Trp His Gly Leu Asp Phe Leu Phe 
305                 310                 315                 320 


Ala Gln Thr Ser Gly Val Asp Thr Glu Lys Asn Thr Tyr Val Ile Glu 
                325                 330                 335     


Gly Lys Asp Pro Val Thr Gln Glu Lys Phe Lys Lys Asn Phe Ala Phe 
            340                 345                 350         


Ala Ile Lys Gln Cys Ile Ala Ala Leu Arg Asn Asn Ser Phe His Tyr 
        355                 360                 365             


Thr Thr Asp Arg Lys Phe Val Ala Asp Asp Asn Ile Leu Ile Glu Lys 
    370                 375                 380                 


Gln Ile Ala Asp Tyr Leu Phe Lys Glu Glu Tyr Ser Arg Leu Pro Lys 
385                 390                 395                 400 


Met Phe Ala Glu Lys Tyr Phe Ser Asn Asn Val Pro Leu Phe Phe Asp 
                405                 410                 415     


Asn Glu Asp Ile Phe Lys Leu Ala Asn Tyr Leu Tyr Cys Gly Glu Ser 
            420                 425                 430         


Val Arg Glu Ala Gln Val Pro Ala Phe Ala Ser Val Ile Lys Arg Lys 
        435                 440                 445             


Tyr Ile Asp Glu Phe Leu Phe Thr Ser Asp Ala Glu Glu Lys Pro Phe 
    450                 455                 460                 


Ile Ser Met Glu Gln Glu Glu Ile Lys Lys Ile Tyr Thr Asn Glu Asp 
465                 470                 475                 480 


Ile Arg Asn Ile Phe Phe Ser Ala Met Tyr Phe Ile Leu Lys Glu Ile 
                485                 490                 495     


Tyr Tyr Tyr Gly Phe Leu Lys Ser Lys Asp Leu Met Glu Arg Phe Ser 
            500                 505                 510         


Lys Ala Phe Glu Gln Tyr Tyr Gln Asn Met Met Asn Asn Lys Arg Asn 
        515                 520                 525             


Lys Glu Tyr Phe Ala Val Asp Asn Phe Lys Lys His Leu Asp Glu Leu 
    530                 535                 540                 


Lys Asn Lys Asn Lys Asn Ile Thr Phe Gly Glu Phe Cys Gln Gln Ile 
545                 550                 555                 560 


Met Thr Asp Tyr Asn Met Gln Asn Gln Asp Leu Lys Asp Val Met Thr 
                565                 570                 575     


Ile Asn Lys Glu Asn Glu Leu Lys Arg Lys Gly Glu Lys Glu Lys Tyr 
            580                 585                 590         


Lys His Tyr Val Leu Ile Leu Tyr Lys Ile Met Gly Asn Ala Phe Lys 
        595                 600                 605             


Lys Tyr Leu Glu Thr Phe Ser Asn Gly Lys Glu Asn Val Tyr Ala Phe 
    610                 615                 620                 


Leu Lys Arg Pro Lys Tyr Ile Leu Ser Asp Asn Lys Ile Ile Ser Leu 
625                 630                 635                 640 


Lys Asp Phe Asp Asp Arg Ser Ile Asn Glu Phe Ile Asn Lys Met Ser 
                645                 650                 655     


Gln Lys Val Lys Ile Lys Ile Tyr Gln Ser Leu Gln Asn Ser Val Thr 
            660                 665                 670         


Lys Tyr Asn Leu Tyr Ala Trp Tyr Met Thr Ala His Phe Leu Ala Gly 
        675                 680                 685             


Lys Gln Leu Asn Leu Leu Ile Gly Asp Phe Lys Ala Phe Lys Gln Tyr 
    690                 695                 700                 


Ile Arg Lys Ile Lys Gln Arg Ala Glu Asn Thr Gly Asn Ala His Lys 
705                 710                 715                 720 


Glu Met Asn Lys Asp Ile Ile Glu Asp Ile Val Glu Tyr Cys Asp Lys 
                725                 730                 735     


Val Ile Lys Ile Leu Glu Phe Val Leu Gln Phe Lys Gly Arg Ile Thr 
            740                 745                 750         


Ala Asn Lys Glu Asp Tyr Phe Ala Asp Glu Glu Glu Tyr Ala Glu Tyr 
        755                 760                 765             


Met Leu Asn Phe Ile Asp Tyr Ser Glu Phe Ile Thr Asn Asn Lys Ile 
    770                 775                 780                 


Asn Gly Lys Val Asp Tyr Ala Thr Ala Leu Lys Glu Tyr Cys Lys Gln 
785                 790                 795                 800 


Asn Met Glu Asn Thr Asn Ser Thr Asp Glu Ile Met Gly Ile Tyr Tyr 
                805                 810                 815     


Asp Gln Lys Asn Leu Ile Leu Asn Arg Asn Val Val Tyr Ser Lys Leu 
            820                 825                 830         


Tyr Gly Glu Ser His Met Leu His His Cys Leu Cys Gly Ala Asp Tyr 
        835                 840                 845             


Asp Tyr Arg Val Lys Gly Glu Asp Ile Gln Asn Tyr Tyr Asp Leu Arg 
    850                 855                 860                 


Lys Asp Leu Asn Asn Val Phe Lys Asn Gly Lys Cys Thr Ser Lys Asp 
865                 870                 875                 880 


Asp Gln Ile Lys Leu Lys Gln Phe Gln Asn Leu Lys Asn Lys Ile Glu 
                885                 890                 895     


Leu Tyr Asp Ile Lys Thr Tyr Thr Asp Leu Val Asn Asp Ile Ile Ala 
            900                 905                 910         


Gln Phe Val Ser Trp Ala Tyr Leu Arg Glu Arg Asp Leu Leu Tyr Phe 
        915                 920                 925             


Gln Leu Gly Tyr His Tyr Ile Lys Leu Phe Trp Lys Asn Glu Thr Asp 
    930                 935                 940                 


Thr Glu Lys Cys Lys Leu Lys Glu Gln Tyr Asn Lys Leu Ser Phe Lys 
945                 950                 955                 960 


Asp Lys Asn Lys Asn Val Ile Asn Ile Thr Glu Gly Ala Leu Leu His 
                965                 970                 975     


Gln Ile Val Ala Val Tyr Asp Tyr Thr Leu Pro Ile Ile Asn Gly Ser 
            980                 985                 990         


Arg Glu Lys Thr Glu His Asn Lys  Ile Ala Leu Ala Ser  Gly Thr Ser 
        995                 1000                 1005             


Gly Thr  Ser Leu Ile Asn Phe  Ile Thr Asn Tyr Cys  Asn Glu Glu 
    1010                 1015                 1020             


Ala Lys  Thr Gly Lys Ala Glu  Thr Tyr Asn Asp Gly  Leu Asp Phe 
    1025                 1030                 1035             


Phe Gly  Lys Glu Ile Asn Arg  Asp Gly Phe Ile Leu  Asp Arg Lys 
    1040                 1045                 1050             


Asp Ile  Ala His Met Lys Tyr  Tyr Ile Phe His Glu  Lys Ser Ile 
    1055                 1060                 1065             


Met Glu  Met Phe Ala Asp Met  Tyr Asn Gly Phe Leu  Met Tyr Asp 
    1070                 1075                 1080             


Thr Lys  Leu Lys Lys Ser Val  Ser Phe Val Ser His  Asn Ile Leu 
    1085                 1090                 1095             


Ala Arg  Tyr Phe Ile Ile Met  Lys Thr Glu Met His  His Ala Ser 
    1100                 1105                 1110             


Glu Glu  Asn Glu Lys Phe Gly  Phe Asp Val Thr Leu  Tyr Ser Asp 
    1115                 1120                 1125             


Lys Phe  Thr Tyr Lys Tyr Glu  Glu Thr Cys Glu Asp  Glu Gln Lys 
    1130                 1135                 1140             


Glu Gly  Glu Glu Lys Gln Lys  Lys Val Asn Val Asp  Ala Arg Ser 
    1145                 1150                 1155             


Glu Glu  Phe Leu Glu Ile Val  Lys Arg Ile Leu Glu  Tyr Lys Glu 
    1160                 1165                 1170             


Cys Lys  
    1175 


<210>  1133
<211>  1250
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1133

Met Lys Ile Thr Lys Ile Asp Gly Val Ser His Tyr Lys Glu Lys Glu 
1               5                   10                  15      


Lys Gly Val Leu Lys Gly Lys Asp Ile Leu Asn Gly Lys Ile Glu Lys 
            20                  25                  30          


Ile Val Lys Lys Arg Tyr Asp Ala Thr Ile Glu Ser Lys Ile Tyr Lys 
        35                  40                  45              


Glu Phe Ile Lys Leu Arg Lys Asn Arg Ile Glu Gln Asn Asn Glu Lys 
    50                  55                  60                  


Ser Ile Leu Lys Leu Ile Lys Leu Asn Ile Asp Lys Asn Glu Lys Glu 
65                  70                  75                  80  


Ile Lys Thr Leu Leu Leu Asn Lys Phe Lys Ile Lys Glu Lys Asn Lys 
                85                  90                  95      


Lys Tyr Asp Lys Tyr Met Leu Asp Glu Asn Lys Leu Asp Asn Asp Ile 
            100                 105                 110         


Lys Ile Tyr Glu Ser Val Glu Ser Leu Tyr Cys Leu Ile Lys Glu Ile 
        115                 120                 125             


Tyr Leu Gly Gln Asn Asn Lys Lys Trp Asn Ile Ser Lys Ile Asp Leu 
    130                 135                 140                 


Glu Lys Ile Met Glu Glu Asp Asn Asn Leu Ile Met Leu Gly Tyr Lys 
145                 150                 155                 160 


Leu Lys Lys Asn Ile Thr Glu Asn Asp Tyr Pro Tyr Leu Tyr Ser Asp 
                165                 170                 175     


Lys Asn Gly Gln Glu Ser Thr Ser Val Tyr Lys Leu Leu Lys Lys Leu 
            180                 185                 190         


Ile Glu Glu Asn Lys Asp Arg Asn Gln Asp Ile Arg Lys Ser Gln Glu 
        195                 200                 205             


Tyr Glu Lys Ile Arg Lys Asn Phe Glu Glu Tyr Lys Asn Arg Lys Ile 
    210                 215                 220                 


Asn Leu Leu Val Lys Ser Ile Lys Asn Asn Lys Ile Asn Ile Gln Tyr 
225                 230                 235                 240 


Ile Asn Asn Glu Ile Lys Ser His Asn Asn Ser Arg Glu Glu Asn Ile 
                245                 250                 255     


Ile Lys Phe Phe Lys Lys Met Ile Glu Glu Lys Asn Glu Pro Ile Leu 
            260                 265                 270         


Lys Asp Lys Leu Lys Leu Phe Lys Leu Glu Val Phe Phe Asp Glu Glu 
        275                 280                 285             


Phe Leu Glu Glu Ile Lys Lys Leu Leu Asp Ser Asp Asp Phe Asp Lys 
    290                 295                 300                 


Ser Tyr Asn Lys Lys Ile Ser Glu Leu Arg Gly Lys Ile Phe Asn Arg 
305                 310                 315                 320 


Ile Arg Glu Lys Ile Lys Asn Asn Lys Asn Arg Asp Glu Leu Glu Asn 
                325                 330                 335     


Ile Tyr Phe Leu Glu Leu Lys Lys Tyr Ile Glu Asn Asn Leu Ser His 
            340                 345                 350         


Lys Lys Glu Lys Asn Lys Asn Asn Asn Asn Asn Thr Gly Glu Glu Lys 
        355                 360                 365             


Ser Lys Glu Leu Tyr Leu Lys Phe Leu Lys Lys Val Leu Phe Ile Asp 
    370                 375                 380                 


Asp Asn Asn Arg Ile Ser Ile Glu Lys Leu Lys Ser Arg Ile Asp Asp 
385                 390                 395                 400 


Asn Phe Lys Asn Leu Leu Ile Gln His Val Ile Glu Tyr Gly Lys Ile 
                405                 410                 415     


Lys Tyr Tyr Val Glu Asn Asp Asp Tyr Ile Arg Asn Ile Val Lys Asn 
            420                 425                 430         


Gly Glu Leu Lys Leu Glu Thr Lys Asp Leu Glu Tyr Ile Lys Thr Lys 
        435                 440                 445             


Glu Thr Leu Ile Arg Lys Met Ala Val Leu Val Ser Phe Ala Ala Asn 
    450                 455                 460                 


Ser Tyr Tyr Asn Leu Phe Gly Ser Val Ser Glu Asp Ile Leu Gly Thr 
465                 470                 475                 480 


Glu Val Val Lys Asn Arg Arg Thr Asn Val Ile Lys Val Lys Ser Tyr 
                485                 490                 495     


Ile Phe Lys Glu Lys Met Leu Asn Tyr Phe Phe Asp Ser Glu Asp Phe 
            500                 505                 510         


Asp Ile Asn Lys Thr Ile Glu Val Leu Glu Ser Ile Ser Tyr Ser Ile 
        515                 520                 525             


Tyr Asn Ile Arg Asn Gly Val Gly His Phe Asn Lys Leu Val Leu Gly 
    530                 535                 540                 


Lys Tyr Lys Lys Lys Asp Ile Asn Thr Asn Lys Arg Val Glu Glu Asp 
545                 550                 555                 560 


Leu Asn Asn Asn Glu Glu Ile Lys Gly Tyr Phe Ile Gln Lys Arg Gly 
                565                 570                 575     


Glu Ile Glu Lys Lys Ile Lys Glu Arg Phe Leu Ser Asn Asn Leu Gln 
            580                 585                 590         


Tyr Tyr Tyr Ala Lys Glu Arg Ile Glu Asn Tyr Phe Glu Val Tyr Glu 
        595                 600                 605             


Phe Glu Ile Leu Lys Glu Lys Ile Pro Phe Ala Pro Asn Phe Lys Arg 
    610                 615                 620                 


Ile Ile Lys Lys Gly Glu Asp Leu Phe Asn Asn Lys Lys Asn Lys Lys 
625                 630                 635                 640 


Tyr Glu Tyr Phe Lys Asn Phe Asp Lys Asn Ser Ala Glu Glu Lys Lys 
                645                 650                 655     


Glu Phe Leu Lys Thr Arg Asn Phe Leu Leu Lys Glu Leu Tyr Tyr Asn 
            660                 665                 670         


Asn Phe Tyr Lys Glu Phe Leu Ser Lys Lys Glu Glu Leu Lys Lys Ile 
        675                 680                 685             


Val Ile Glu Val Lys Glu Glu Lys Lys Asn Arg Gly Asn Asn Lys Lys 
    690                 695                 700                 


Ser Gly Val Ser Phe Gln Asn Ile Asp Asp Tyr Asp Thr Lys Ile Asn 
705                 710                 715                 720 


Ile Ser Asp Tyr Ile Ala Ser Ile His Lys Lys Glu Met Glu Arg Val 
                725                 730                 735     


Glu Lys Tyr Asn Glu Glu Lys Gln Lys Asp Thr Ala Lys Tyr Ile Arg 
            740                 745                 750         


Asp Phe Val Glu Glu Ile Phe Leu Thr Gly Phe Ile Asn Tyr Leu Glu 
        755                 760                 765             


Lys Asp Glu Arg Leu His Phe Leu Lys Glu Glu Phe Ser Val Leu Cys 
    770                 775                 780                 


Asn Ser Asn Asn Asn Val Ile Asp Phe Asn Val Asn Ile Asn Glu Glu 
785                 790                 795                 800 


Lys Ile Lys Glu Phe Leu Lys Glu Asn Asp Ser Lys Thr Leu Asn Leu 
                805                 810                 815     


Tyr Leu Phe Phe Asn Met Ile Asp Ser Lys Arg Ile Ser Glu Phe Arg 
            820                 825                 830         


Asn Glu Leu Ile Lys Tyr Lys Gln Phe Thr Lys Lys Arg Leu Asp Glu 
        835                 840                 845             


Glu Lys Glu Phe Leu Gly Ile Lys Ile Glu Leu Tyr Glu Thr Leu Ile 
    850                 855                 860                 


Glu Phe Val Ile Leu Thr Arg Glu Lys Leu Asp Thr Lys Lys Ser Glu 
865                 870                 875                 880 


Glu Thr Asp Ala Trp Leu Val Asp Lys Leu Tyr Val Lys Glu Lys Asn 
                885                 890                 895     


Glu Cys Asn Glu Tyr Glu Tyr Lys Glu Tyr Glu Glu Ile Leu Lys Leu 
            900                 905                 910         


Phe Val Asp Glu Lys Ile Leu Ile Ser Lys Glu Ala Pro Tyr Tyr Ala 
        915                 920                 925             


Thr Asn Asn Lys Thr Pro Ile Ile Leu Ser Asn Phe Glu Lys Thr Arg 
    930                 935                 940                 


Lys Tyr Gly Thr Gln Asn Leu Leu Ala Lys Ile Gln Ser Ser Tyr Lys 
945                 950                 955                 960 


Tyr Asn Glu Ile Glu Lys Gln Lys Ile Glu Asn Tyr Asn Glu Lys Lys 
                965                 970                 975     


Glu Ser Glu Lys Lys Lys Lys Ser Asn Ile Glu Lys Leu Gln Asp Leu 
            980                 985                 990         


Lys Val Glu Leu His Lys Lys Trp  Glu Gln Asn Lys Ile  Thr Glu Lys 
        995                 1000                 1005             


Glu Ile  Lys Lys Tyr Asn Asp  Thr Ile Lys Glu Ile  Arg Glu Tyr 
    1010                 1015                 1020             


Asn Tyr  Leu Lys Asn Lys Glu  Glu Leu Gln Asn Val  Tyr Leu Leu 
    1025                 1030                 1035             


His Glu  Ile Leu Ser Asp Leu  Leu Ala Arg Asn Val  Ala Phe Phe 
    1040                 1045                 1050             


Asn Lys  Trp Glu Arg Asp Phe  Lys Phe Ile Val Ile  Ala Ile Lys 
    1055                 1060                 1065             


Gln Phe  Leu Arg Glu Asn Asp  Lys Glu Lys Val Asn  Glu Phe Leu 
    1070                 1075                 1080             


Asn Pro  His Lys Ser Asp Gly  Ser Arg Asp Asn Phe  Ser Val Thr 
    1085                 1090                 1095             


Asn Tyr  Arg Ser Lys Met Lys  Ser Ile Ile Asn Asn  Ile His Glu 
    1100                 1105                 1110             


Asn Phe  Met Ser Leu Leu Phe  Leu Asn Asn Asn Leu  Ala Thr Gly 
    1115                 1120                 1125             


Gly Ile  Gln Met Gly Arg Asn  Asn Asn Phe Thr Trp  Gly Asn Leu 
    1130                 1135                 1140             


Arg Asn  Tyr Ile Ala His Phe  Glu Tyr Leu His Lys  Glu Lys Asp 
    1145                 1150                 1155             


Thr Ile  Ser Phe Ile Gly Gln  Ala Asn Leu Leu Ile  Lys Leu Phe 
    1160                 1165                 1170             


Ser Tyr  Asp Lys Lys Val Gln  Asn His Ile Ile Lys  Ser Met Lys 
    1175                 1180                 1185             


Thr Leu  Leu Glu Lys Tyr Asn  Ile Glu Ile Arg Phe  Glu Ile Ser 
    1190                 1195                 1200             


Asn Asp  Ser Glu Glu Ile Phe  Glu Tyr Lys Ile Lys  Tyr Ile Asn 
    1205                 1210                 1215             


Ser Lys  Lys Gly Lys Met Leu  Gly Lys Asn Asn Glu  Phe Glu Ile 
    1220                 1225                 1230             


Leu Glu  Asn Glu Phe Val Arg  Asn Val Lys Ala Leu  Leu Glu Tyr 
    1235                 1240                 1245             


Ser Lys  
    1250 


<210>  1134
<211>  1399
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1134

Met Gly Asn Leu Phe Gly His Lys Arg Trp Tyr Glu Val Ser Asp Arg 
1               5                   10                  15      


Gly Asp Asn Lys Ile Lys Arg Lys Val Lys Val Lys Arg Asn Tyr Asp 
            20                  25                  30          


Gly Asn Lys Tyr Ile Leu Asn Ile Asn Glu Asn Asn Asn Lys Glu Lys 
        35                  40                  45              


Ile Asp Asn Asn Lys Phe Ile Arg Glu Phe Val Asn Tyr Lys Lys Asn 
    50                  55                  60                  


Asp Asn Val Leu Ile Glu Phe Lys Arg Lys Phe His Ala Gly Asn Ile 
65                  70                  75                  80  


Leu Phe Lys Leu Lys Gly Asn Lys Arg Ser Ile Glu Asp Ser Asn Asp 
                85                  90                  95      


Phe Leu Lys Thr Glu Glu Ile Ile Leu Asp Lys Glu Val Tyr Gly Gln 
            100                 105                 110         


Ser Glu Lys Leu Arg Asn Glu Lys Gly Ile Thr Lys Gln Asp Ile Leu 
        115                 120                 125             


Lys Glu Ile Ile Asp Lys Gly Ile Asp Lys Ser Asn Asp Lys Ile Leu 
    130                 135                 140                 


Val Lys Thr Lys Phe Gly Lys Glu Ile Thr Ile Asn Phe Thr Asp Glu 
145                 150                 155                 160 


Asp Lys Lys Asn Lys Lys Glu Tyr Gln Ile Thr Leu Lys Ile Ile Pro 
                165                 170                 175     


Glu Asn Glu Leu Lys Ile Lys Arg Glu Val Tyr Asn Val Phe Lys Ile 
            180                 185                 190         


Ile Asn Met Asn Leu Tyr Gln Ile Ile Lys Arg Ile Ile Glu Asn Lys 
        195                 200                 205             


Glu Ile Phe Lys Asn Arg Tyr Tyr Asp Glu Ile Leu Lys Glu Lys Leu 
    210                 215                 220                 


Ser Lys Asn Asn Gln Ile Ile Asn Thr Leu Thr Asn Leu Asn Lys Ile 
225                 230                 235                 240 


Arg Lys Glu Ile Arg Asp Asn Arg Asp Asn Ile Ile Gly Phe Val Lys 
                245                 250                 255     


Phe Tyr Leu Asn Val Ser Gly Asp Lys Lys Lys Ser Glu Asn Lys Lys 
            260                 265                 270         


Met Phe Val Glu Lys Ile Leu Asn Thr Asn Val Asp Leu Thr Val Glu 
        275                 280                 285             


Asp Ile Val Asp Phe Ile Val Lys Glu Leu Lys Phe Trp Asn Ile Thr 
    290                 295                 300                 


Lys Arg Ile Glu Lys Val Lys Lys Phe Asn Asn Glu Phe Leu Glu Asn 
305                 310                 315                 320 


Arg Arg Asn Arg Thr Tyr Ile Lys Ser Tyr Val Leu Leu Asp Lys His 
                325                 330                 335     


Glu Lys Phe Lys Ile Glu Arg Glu Asn Lys Lys Asp Lys Ile Val Lys 
            340                 345                 350         


Phe Phe Val Glu Asn Ile Lys Asn Asn Ser Ile Lys Glu Lys Ile Glu 
        355                 360                 365             


Lys Ile Leu Ala Glu Phe Lys Ile Asp Glu Leu Thr Lys Lys Leu Glu 
    370                 375                 380                 


Lys Glu Leu Lys Lys Gly Asn Cys Asp Thr Glu Ile Phe Gly Ile Phe 
385                 390                 395                 400 


Lys Lys His Tyr Lys Val Asn Phe Asp Ser Lys Lys Phe Ser Asn Lys 
                405                 410                 415     


Ser Asp Glu Glu Lys Glu Leu Tyr Lys Ile Ile Tyr Arg Tyr Leu Lys 
            420                 425                 430         


Gly Arg Ile Glu Lys Ile Leu Ile Asn Glu Gln Lys Val Arg Leu Lys 
        435                 440                 445             


Lys Met Glu Lys Ile Glu Ile Glu Lys Ile Leu Asp Glu Ser Val Leu 
    450                 455                 460                 


Ser Glu Lys Ile Leu Lys Arg Val Lys Gln Tyr Thr Leu Glu His Ile 
465                 470                 475                 480 


Met Tyr Leu Gly Lys Leu Ile His Asn Lys Ile Asn Met Ala Thr Val 
                485                 490                 495     


Asn Thr Asn Asp Phe Phe Arg Leu His Ala Lys Glu Glu Leu Asp Leu 
            500                 505                 510         


Glu Leu Ile Thr Phe Phe Ala Ser Thr Asn Met Glu Leu Asn Lys Ile 
        515                 520                 525             


Phe Ser Arg Glu Asn Ile Asn Asn Asp Glu Asn Ile Asp Phe Phe Gly 
    530                 535                 540                 


Gly Asp Arg Glu Lys Asn Tyr Val Leu Asp Lys Lys Asn Leu Asn Ser 
545                 550                 555                 560 


Lys Ile Lys Ile Ile Arg Asp Leu Asp Phe Ile Asp Asn Lys Asn Asn 
                565                 570                 575     


Ile Thr Asn Asn Phe Ile Ser Lys Phe Thr Lys Ile Gly Thr Asn Glu 
            580                 585                 590         


Arg Asn Arg Ile Leu His Ala Ser Ser Lys Glu Arg Asp Leu Gln Gly 
        595                 600                 605             


Thr Gln Asp Asp Tyr Asn Lys Val Ile Asn Ile Ile Gln Asn Leu Lys 
    610                 615                 620                 


Ile Ser Asp Glu Glu Val Ser Lys Ala Leu Asn Leu Asp Val Val Phe 
625                 630                 635                 640 


Lys Asp Lys Lys Asn Ile Ile Thr Lys Ile Asn Asp Ile Glu Ile Ser 
                645                 650                 655     


Glu Glu Asn Asn Ser Val Ile Lys Tyr Leu Pro Ser Phe Ser Lys Val 
            660                 665                 670         


Leu Pro Glu Ile Leu Asn Leu Tyr Lys Asn Lys Asn Lys Asn Asn Pro 
        675                 680                 685             


Phe Asp Thr Thr Glu Thr Glu Arg Ile Ile Leu Asn Ala Leu Ile Tyr 
    690                 695                 700                 


Val Asn Lys Glu Leu Tyr Lys Lys Leu Ile Leu Glu Lys Asn Leu Glu 
705                 710                 715                 720 


Glu Asn Glu Ser Lys Asn Lys Phe Leu Lys Glu Leu Lys Lys Asn Leu 
                725                 730                 735     


Gly Gly Thr Asp Glu Ile Asp Glu Asn Ile Ile Glu Ser Tyr Tyr Lys 
            740                 745                 750         


Asn Thr Gln Ile Ser Ala Ser Lys Gly Asn Asn Lys Ala Ile Lys Lys 
        755                 760                 765             


Tyr Gln Lys Lys Ile Ile Glu Cys Tyr Ile Lys Tyr Leu Glu Glu Asn 
    770                 775                 780                 


Tyr Arg Glu Leu Phe Asp Phe Ser Asp Phe Lys Met Asn Ile Gln Glu 
785                 790                 795                 800 


Ile Lys Lys Gln Ile Lys Glu Ile Asn Asp Asn Lys Thr Tyr Lys Arg 
                805                 810                 815     


Ile Thr Ile Lys Thr Ser Asp Lys Ser Ile Val Ile Asn Asp Asp Phe 
            820                 825                 830         


Glu Tyr Ile Ile Ser Ile Phe Ala Leu Leu Asn Ser Asn Ala Val Ile 
        835                 840                 845             


Asn Lys Ile Arg Asn Arg Phe Phe Ala Thr Ser Val Trp Leu Asp Thr 
    850                 855                 860                 


Ser Glu Tyr Gln Asn Ile Ile Asn Ile Leu Asp Glu Ile Met Gln Leu 
865                 870                 875                 880 


Asn Thr Leu Arg Asn Glu Cys Ile Thr Glu Asn Trp Asn Leu Asn Leu 
                885                 890                 895     


Glu Glu Phe Ile Gln Lys Met Lys Glu Ile Glu Lys Asp Phe Asp Asp 
            900                 905                 910         


Phe Lys Ile Gln Thr Lys Lys Asp Ile Phe Asn Gly Asn Tyr Glu Ser 
        915                 920                 925             


Ile Lys Asn Asn Val Leu Ser Lys Phe Ile Gly Phe Ser Asp Val Gln 
    930                 935                 940                 


Lys Ile Leu Glu Glu Lys Leu Asn Asn Leu Ile Asp Phe Glu Asn Asp 
945                 950                 955                 960 


Asn Glu Ile Lys Lys Ser Val Asn Leu Asp Ser Leu Asn Pro Asp Glu 
                965                 970                 975     


Arg Arg Asn Leu Met Pro Asn Ile Asn Pro Lys Lys Gly Gly Ile Asp 
            980                 985                 990         


Leu Ile Lys Glu Ile Asp Lys Leu  Ile Val Ile Glu Lys  Asn Asn Ile 
        995                 1000                 1005             


Glu Lys  Asn Ile Leu Leu Lys  Ile Ile Phe Asn Ser  Asp Phe Leu 
    1010                 1015                 1020             


Glu Lys  Tyr Lys Lys Glu Ile  Asp Asn Leu Ile Glu  Asp Thr Glu 
    1025                 1030                 1035             


Ser Glu  Asn Lys Asn Lys Phe  Glu Lys Ile Tyr Tyr  Pro Glu Glu 
    1040                 1045                 1050             


His Lys  Asn Glu Leu Tyr Ile  Tyr Lys Lys Asn Leu  Phe Leu Asn 
    1055                 1060                 1065             


Ile Gly  Asn Pro Asn Phe Asp  Lys Ile Tyr Glu Leu  Ile Ser Lys 
    1070                 1075                 1080             


Asp Ile  Lys Asn Ala Asn Thr  Glu Ile Leu Phe Asn  Asp Asp Ile 
    1085                 1090                 1095             


Arg Lys  Asn Lys Ile Ala Glu  Ile Asp Val Ile Leu  Lys Asn Leu 
    1100                 1105                 1110             


Asn Asp  Lys Leu Asn Gly Tyr  Ser Lys Glu Tyr Lys  Glu Lys Tyr 
    1115                 1120                 1125             


Ile Lys  Lys Leu Lys Glu Asn  Gln Glu Asn Ser Asp  Phe Phe Thr 
    1130                 1135                 1140             


Lys Asn  Ile Gln Asn Glu Asn  Tyr Asn Ser Phe Glu  Glu Phe Lys 
    1145                 1150                 1155             


Glu Asp  Tyr Asn Lys Val Ser  Glu Tyr Lys Lys Ile  Arg Asp Leu 
    1160                 1165                 1170             


Val Glu  Phe Asn Tyr Leu Asn  Lys Ile Glu Ser Tyr  Leu Ile Asp 
    1175                 1180                 1185             


Ile Asn  Trp Lys Leu Ala Ile  Gln Met Ala Arg Phe  Glu Arg Asp 
    1190                 1195                 1200             


Met His  Tyr Ile Val Asn Gly  Leu Asp Tyr Leu Tyr  Ile Ile Arg 
    1205                 1210                 1215             


Leu Glu  Lys Asp Arg Asn Gln  Asp Arg Ser Ser Pro  Tyr Pro Lys 
    1220                 1225                 1230             


Tyr Lys  Asn Gly Val Leu Asp  Tyr Thr Lys Ser Tyr  Tyr Asn Phe 
    1235                 1240                 1245             


Lys Asp  Tyr Gln Glu Phe Met  Asp Ile Cys Ser Lys  Phe Gly Ile 
    1250                 1255                 1260             


Asp Leu  Ser Glu Asn Ser Glu  Ile Asn Lys Pro Glu  Asn Glu Ser 
    1265                 1270                 1275             


Ile Arg  Asn Tyr Ile Ser His  Phe Tyr Ile Val Arg  Asn Pro Phe 
    1280                 1285                 1290             


Val Asp  Tyr Ser Ile Ala Glu  Gln Ile Asp Arg Val  Ser Asn Leu 
    1295                 1300                 1305             


Leu Ser  Tyr Ser Thr Arg Tyr  Asn Asn Ser Thr Tyr  Ala Ser Val 
    1310                 1315                 1320             


Phe Glu  Val Phe Lys Lys Asp  Val Asp Leu Asp Tyr  Asp Lys Leu 
    1325                 1330                 1335             


Lys Thr  Lys Phe Lys Leu Phe  Asp Asp Glu Lys Asn  Asp Asp Ile 
    1340                 1345                 1350             


Lys Ile  Leu Glu Ile Lys Asn  Leu Ile Glu Ser Lys  Lys Val Ser 
    1355                 1360                 1365             


Val Leu  Glu Leu Glu Ser Tyr  Asn Ser Asp Tyr Ile  Lys Asn Leu 
    1370                 1375                 1380             


Ile Ile  Glu Leu Leu Thr Lys  Val Glu Asn Lys Asp  Glu Ile Ser 
    1385                 1390                 1395             


Ser 
    


<210>  1135
<211>  1330
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1135

Met Lys Arg Glu Lys Asn Ile Thr Ile Met Lys Ile Ser Lys Val Asn 
1               5                   10                  15      


His Arg Arg Thr Ala Val Ala Leu Asn Gly Asp Lys Ser Glu Leu Gly 
            20                  25                  30          


Gly Ile Leu Tyr Glu Ala Pro Val Gln Lys Asp Arg Asn Gly Asn Tyr 
        35                  40                  45              


Asn Asp Val Ile Ala Glu Thr Gly Lys Val Val Asn Glu Ala Leu Asp 
    50                  55                  60                  


Lys Lys Ser Arg Leu Tyr Thr Pro Phe Asn Asn Gln Lys Val Ile Ile 
65                  70                  75                  80  


Asp Lys Asn Leu Gln Arg Tyr Ala Asn Asn Leu Lys Arg Cys Tyr Ile 
                85                  90                  95      


Asn Phe Val Lys Gln Tyr Val Asn Asn Lys Ser Phe Asn Tyr Lys Ala 
            100                 105                 110         


Met Gln Phe Ile Pro Asp Ile Gln Asn Pro Lys Thr Asn Asp Ala Val 
        115                 120                 125             


Asn Tyr Arg Thr Asp Arg Asp Asn Val Tyr Asn Lys Asn Lys Tyr Tyr 
    130                 135                 140                 


Asp Lys Gln Thr Lys Ser Lys Ser Lys Lys Phe Ile Tyr Glu Lys Ile 
145                 150                 155                 160 


Val Ile Pro Gln Asn Glu Gln Asn Ile Val Ile Ser Ala Leu Val Asn 
                165                 170                 175     


Cys Ser Leu Arg Lys Ser Leu Arg Lys Asp Val Ser Tyr Lys Thr Lys 
            180                 185                 190         


Ser Gly Glu Ile Lys Thr Tyr Asn Leu Pro Glu Leu Val Lys Lys Ser 
        195                 200                 205             


Met Arg Phe Tyr Cys Leu Glu Gly Gln Arg Glu Pro Asp Glu Lys Glu 
    210                 215                 220                 


Lys Tyr Glu Met Tyr Ile Leu Phe Ser Tyr Met Lys Glu Asp Lys Arg 
225                 230                 235                 240 


Thr Lys Asn Thr Asp Leu Leu Val Lys Ser Ile Ser Asn Gln Asn Thr 
                245                 250                 255     


Lys Val Lys Val Glu Asp Ile Asp Gly Asn Lys Leu Leu Lys Leu Ser 
            260                 265                 270         


Ile Ala Asp Thr Lys Lys Lys Pro Leu Trp Glu Tyr Leu Ile Lys Tyr 
        275                 280                 285             


Ala Asp Ser Ser Arg Gln Arg Glu Leu Met Tyr Asp Ile Arg Lys Lys 
    290                 295                 300                 


Ile Ile Leu Tyr Val Ala Gly Ile Glu Glu Tyr Glu Asn Ile Lys Glu 
305                 310                 315                 320 


Asp Ser Gly Leu Ser Lys Val Ser Trp Ser Lys Tyr Asn Ile Ser Asp 
                325                 330                 335     


Asn Lys Met Phe Phe Asp Ile Asn Ser Cys Thr Asp Lys Arg Lys Gln 
            340                 345                 350         


Asn Leu Glu Ile Lys Ile Arg Glu Ala Asn Ile Glu His Tyr Arg Asn 
        355                 360                 365             


Ala Ser Ser Lys Leu Cys Asp Asp Glu Ser Ile Phe Trp Phe Gln His 
    370                 375                 380                 


Phe Glu Gly Val Ile Glu Thr Leu Phe Ser Lys Lys Ser Lys Ile Ser 
385                 390                 395                 400 


Glu Glu Arg Leu Gly Cys Ala Tyr Ile Cys Asp Tyr Leu Trp Lys Asp 
                405                 410                 415     


Phe Leu Ser Tyr Leu Ala Ala Lys Tyr Ile Asp Leu Gly Lys Gly Val 
            420                 425                 430         


Tyr His Phe Thr Met Lys Asp Lys Leu Asp Met Leu Asn Lys Asn Glu 
        435                 440                 445             


Ala Val Thr Asp Leu Arg Phe Gly Ile Val Ser Glu Lys Tyr Glu Lys 
    450                 455                 460                 


Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Glu Leu 
465                 470                 475                 480 


Asp Arg Asn Ile Ala Ala Tyr Val Thr Phe Ala Ala Asp Ile Phe Ala 
                485                 490                 495     


Lys Ser Val Ile Lys Ser Asp Tyr Arg Thr Lys Lys Asp Asn Asn Ser 
            500                 505                 510         


Asp Val Leu Gln Tyr Ser Asp Lys Glu Phe Arg Asn Ser Glu Val Ile 
        515                 520                 525             


Arg Asp Asn Ala Glu Lys Asn Ile Leu Gln Tyr Trp Gly Gly Tyr Ser 
    530                 535                 540                 


Arg Trp Gly Thr Glu Asn Ser Lys Leu Pro Glu Asn Asn Lys Val Ser 
545                 550                 555                 560 


Asp Phe Gly Lys Leu Asp Val Ser Asp Leu Cys Ile Asp Ile Lys Lys 
                565                 570                 575     


His Leu Ala Gly Ile Arg Asn Ser Ser Val His Tyr Thr Thr Lys Ile 
            580                 585                 590         


Lys Asn Glu Ser Ala Ala Asp Gly Ser Asn Val Lys Ile Leu Phe Glu 
        595                 600                 605             


Lys Asp Leu Ala Asp Ile Asn Ile Ile Tyr Ala Asp Lys Tyr Tyr Ser 
    610                 615                 620                 


Asn Asn Val Trp Met Phe Tyr Ser Leu Glu Asp Ile Asn Lys Leu Ile 
625                 630                 635                 640 


Ala Phe Leu Tyr Lys Glu Lys Arg Val Ile Arg Gln Val Gln Ile Pro 
                645                 650                 655     


Ser Phe Ser Arg Ile Leu Lys Arg Lys Ala Met Gln Asp Val Ile Asn 
            660                 665                 670         


Glu Ile Phe Lys Asp Asp Phe Asp Glu Asn Ile Val Asn Pro Glu Leu 
        675                 680                 685             


Lys Glu Lys Tyr Arg Asn Ser Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
    690                 695                 700                 


Tyr Asn Ala Phe Ile Ile Gln Pro Glu Leu Lys Glu Lys Phe Lys Asp 
705                 710                 715                 720 


Lys Ile Lys Ile Met Lys Ser Glu Leu Tyr Asn Lys Leu Lys Thr Ile 
                725                 730                 735     


Asp Lys Lys Glu Tyr Lys Ala Leu Tyr Cys Met Leu Ser Asn Glu Glu 
            740                 745                 750         


Ser Ala Leu Lys Asn Phe Ala Asp Arg Ile Tyr Ser Val Asp Gly Asp 
        755                 760                 765             


Asn Val Ser Phe Ala Asp Ile Cys Lys Ile Leu Met Thr Asp Tyr Asn 
    770                 775                 780                 


Met Gln Asn Gln Glu Lys Lys Asn Ile Glu Ser Met Glu Gln Lys Lys 
785                 790                 795                 800 


Lys Asn Lys Gly Lys Asp Glu Asn Tyr Lys His Phe Pro Leu Leu Leu 
                805                 810                 815     


His Lys Val Leu Lys Glu Leu Phe Ile Glu Tyr Leu Lys Gln Thr His 
            820                 825                 830         


Glu Leu Glu Phe Leu Arg Asn Asn Ile Cys Ile Lys Ser Asp Val Thr 
        835                 840                 845             


Met Glu Ser Phe Glu Ser Gln Ile Lys Gly Val Glu Ile Tyr Lys Asp 
    850                 855                 860                 


Leu Lys Glu Lys Ile Asp Lys Asn Asn Ser Leu Leu Asp Trp Tyr Val 
865                 870                 875                 880 


Ile Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asn 
                885                 890                 895     


Ile Lys Asn Tyr Ile Gln Phe Ala Thr Asn Ile Asp Lys Arg Ala Glu 
            900                 905                 910         


Ser Val Lys Asn Leu Thr Glu Ser Gly Met Val Lys Arg Ile Gln Tyr 
        915                 920                 925             


Tyr Asp Asp Ile Val Arg Thr Leu Glu Phe Ser Ala Gln Tyr Ile Gly 
    930                 935                 940                 


Lys Ile Ser Asn Asn Ile Asn Asp Tyr Phe Asn Ser Glu Asp Glu Tyr 
945                 950                 955                 960 


Val Ser Phe Leu Ser Lys Tyr Val Gly Phe Ile Asn Asp Lys Ser Glu 
                965                 970                 975     


Asp Val Leu Thr Glu Leu Lys Asp Phe Cys Arg Glu Lys Ile Asn Asn 
            980                 985                 990         


Gly Ser Gln Ile Ile Gly Ile Tyr  Tyr Gly Gly Asp Asn  Val Ile Ile 
        995                 1000                 1005             


Asn Arg  Asn Val Ile Tyr Ala  Gln Met Tyr Ser Asn  Ala Glu Val 
    1010                 1015                 1020             


Phe Ser  Asn Ile Tyr Lys Lys  Val Thr Lys Asn Asp  Ile Ile Asn 
    1025                 1030                 1035             


Tyr Tyr  Glu Lys Gln Asn Asp  Leu Lys Asp Val Phe  Lys Ser Gly 
    1040                 1045                 1050             


Val Cys  Gln Asn Glu Gly Glu  Gln Arg Ser Leu Cys  Glu Phe Gln 
    1055                 1060                 1065             


Gln Leu  Lys Asn Arg Ile Glu  Leu Thr Glu Leu Ser  Thr Tyr Ala 
    1070                 1075                 1080             


Asp Met  Val Asn Asp Phe Met  Ala Gln Phe Val Glu  Trp Ala Tyr 
    1085                 1090                 1095             


Leu Arg  Glu Arg Asp Leu Met  Tyr Phe Gln Leu Gly  Ile His Tyr 
    1100                 1105                 1110             


Ile Arg  Leu Phe Tyr Ser Asp  Asn Val Leu Asp Glu  Lys Tyr His 
    1115                 1120                 1125             


Lys Leu  Arg Asp Asn Val Ile  Asp Ile Glu Glu Gly  Ala Leu Leu 
    1130                 1135                 1140             


Tyr Gln  Ile Val Ala Met Tyr  Asp Tyr Glu Leu Arg  Ile Phe Glu 
    1145                 1150                 1155             


Thr Asp  Asn Ser Gly Asn Ala  Lys Arg Ile Gly Gln  Gly Gly Pro 
    1160                 1165                 1170             


Gly Lys  Ser Ile Pro Val Phe  Leu Lys Lys Tyr Cys  Asn Gly Thr 
    1175                 1180                 1185             


Asp Val  Tyr Glu Cys Gly Leu  Glu Leu Phe Glu Asp  Ile Asn Gln 
    1190                 1195                 1200             


His Glu  His Ile Ile Arg Phe  Arg Asn Asp Ile Ala  His Met Arg 
    1205                 1210                 1215             


Tyr Met  Ser Asn Gln Ala Met  Asn Ile Met Ser Ile  Val Ser Asn 
    1220                 1225                 1230             


Ile Tyr  Lys Ser Phe Phe Val  Tyr Asp Thr Lys Leu  Lys Lys Ser 
    1235                 1240                 1245             


Ile Ser  Leu Val Phe Lys Asn  Ile Leu Met Arg Tyr  Gly Val Ile 
    1250                 1255                 1260             


Ala Asp  Leu Val Phe Ser Tyr  Asn Asn Lys Asn Gln  Ser Ile Lys 
    1265                 1270                 1275             


Asp Asp  Met Asp Ile Asn Ile  Ile Asn Ile Lys Asn  Leu Lys Ser 
    1280                 1285                 1290             


Asp Lys  Tyr Val Tyr Lys Ile  Val Asn Glu Asp Ile  Val Lys Gln 
    1295                 1300                 1305             


Val Glu  Ile Glu Ile Arg Asn  Gln Val Phe Leu Glu  Gln Leu His 
    1310                 1315                 1320             


Asn Leu  Leu Tyr Phe Ser Arg  
    1325                 1330 


<210>  1136
<211>  1312
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1136

Met Lys Phe Ser Lys Val Gly His Val Arg Thr Ala Val Ser Val Thr 
1               5                   10                  15      


Asp Asn Gly Val Glu Gly Ile Ile Tyr Glu Asn Pro Ala Val Asp Gly 
            20                  25                  30          


Asn Tyr Pro Val Gln Asn Leu Asn Glu Arg Phe Asp Ile Leu Asn Arg 
        35                  40                  45              


Asn Ala Lys Ala Leu Tyr Arg Ile Phe Val Pro Ala Lys Gly Lys Glu 
    50                  55                  60                  


Cys Asp Ala Ala Lys Thr Val Arg Lys Lys Gly Glu Asp Leu Ile Arg 
65                  70                  75                  80  


Ala Leu Leu Lys Thr Gly Gly Ser Asp Pro Thr Gly Ala Gln Leu Ala 
                85                  90                  95      


Phe Leu Lys Ser Thr Ile Ile Ala Ser Tyr Ala Leu Ser Asp Ala Glu 
            100                 105                 110         


Ala Tyr Ala Ile Gly Ile Leu Val Arg Gln Ser Leu Arg Gln Ser Leu 
        115                 120                 125             


Arg Arg Glu Val Lys Lys Asp Gly Lys Glu Ile Arg Val Pro Asp Val 
    130                 135                 140                 


Ile Glu Gly Ile Leu Ser Ala Leu Val Leu Val Ser Asp Arg Asp Ile 
145                 150                 155                 160 


Ser Gly Tyr Leu Glu Lys Ile Asp Gly Leu Gly Glu Glu Ala Ile Ile 
                165                 170                 175     


Val Phe Leu Gln Ile Leu Asn Glu Asp Tyr Asn Lys Asp Leu Gln Lys 
            180                 185                 190         


Lys Asn Thr Val Lys Ser Leu Gln Arg Gln Asn Val Lys Ala Gln Pro 
        195                 200                 205             


Leu Gln Glu Lys Glu Ser Phe Leu Leu Arg Pro Ala Asp Ala Gly His 
    210                 215                 220                 


Pro Lys Lys Arg Tyr Arg Phe Asp Phe Met Thr Glu Tyr Ala Gly Ala 
225                 230                 235                 240 


Asp Gln Ala Ala Lys Glu Glu Met Leu Val Arg Ile Arg Gln Leu Ile 
                245                 250                 255     


Leu Leu Phe Phe Ser Gly Lys Glu Ala Tyr Glu Glu Ala Ser Gly Lys 
            260                 265                 270         


Asp Cys Gly Val Asn Ala Arg Ser Phe Gly Ala Leu Leu Pro Gln Pro 
        275                 280                 285             


Glu Glu Tyr Phe Leu Gly Asn Ser Val Phe His Asp Tyr Tyr Arg Gln 
    290                 295                 300                 


Ile Asp Ala Tyr Leu Ser Glu Ile Ala Cys Tyr Glu Glu Glu Glu Lys 
305                 310                 315                 320 


Glu Ile Glu Ala Lys Phe Lys Arg Tyr Glu Asp Lys Lys Asp Ser Leu 
                325                 330                 335     


Ala Glu Ile Lys Lys Lys Lys Gly Lys Ala Gly Arg Arg Ile Asp Glu 
            340                 345                 350         


Cys Tyr Glu Lys Ile Arg Ala Leu Ala Ser Gln Thr Ile Thr Asp Ala 
        355                 360                 365             


Tyr Arg Gln Ala Val Lys Glu Asp Leu Asp Gly Ser Asp Ile Phe Trp 
    370                 375                 380                 


Ile Asp Tyr Leu Gln Lys Asp Ala Val Arg Gln Phe Gly Lys Gly Lys 
385                 390                 395                 400 


Arg Ile Pro Glu Tyr Lys Leu Ser Ala Arg Tyr Leu Cys Lys His Ala 
                405                 410                 415     


Trp Asp Gly Trp Thr Ala Phe Leu Ser Arg Lys Tyr Val Asp Leu Gly 
            420                 425                 430         


Lys Ala Val Tyr His Phe Ala Met Pro Asp Leu Tyr Asn Met Asp Pro 
        435                 440                 445             


Asp Ser Glu Val Ile Met Gly Glu Val Arg Pro Glu Tyr Arg Lys Gly 
    450                 455                 460                 


Leu Ser Thr Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Asn Leu Asp 
465                 470                 475                 480 


Arg Asp Ile Ser Thr Ala Val Ser Phe Ala Val Asn Ser Phe Ser Arg 
                485                 490                 495     


Ser Ile Cys Gly Tyr Glu Arg Lys Glu Gly His Glu Asp Val Leu Leu 
            500                 505                 510         


Leu Asn Asp Thr Gln Leu Lys Glu Asp Leu Leu Asp Asp Ala Gly Lys 
        515                 520                 525             


Arg Val Leu Arg Phe Phe Gly Gly Ile His Ala Trp Glu Ser Asn Glu 
    530                 535                 540                 


Glu Ile Ser Leu Tyr Ala Ala Asp Asp Lys Gly Tyr Glu Leu Val Lys 
545                 550                 555                 560 


Pro Met Gln Gln Met Leu Tyr Ala Val Arg Asn Ser Ala Phe His Tyr 
                565                 570                 575     


Thr Gly Lys Asp Asp Pro Ala Gly Tyr Gly Asp Thr Ala Leu Leu Glu 
            580                 585                 590         


Thr Met Phe Gly Gln Glu Glu Glu Trp Leu Gly Lys Ile Leu Arg Lys 
        595                 600                 605             


Lys Tyr Phe Ser Asn Asn Ala His Lys Phe Tyr Lys Asn Ser Asp Ile 
    610                 615                 620                 


Thr Arg Leu Met Asp Phe Leu Tyr Lys Glu Gln Pro Val Arg Pro Pro 
625                 630                 635                 640 


Gln Ile Pro Ser Phe Asn Arg Ile Met Asn Arg Asn Ser Ala Tyr Gln 
                645                 650                 655     


His Pro Lys Ile Val Lys Gly Arg Ser Lys Ser Arg Val Ser Gly Gly 
            660                 665                 670         


Glu Ile Lys Tyr Thr Glu Met Phe Lys Gly Thr Leu Phe Phe Leu Leu 
        675                 680                 685             


Lys Glu Ile Tyr Tyr Tyr Gly Phe Leu Gln Glu Lys Asp Val Thr Gln 
    690                 695                 700                 


Arg Phe Leu Asp Phe Val Lys Asp Pro Val Asn Lys Ser Ala Ala Gln 
705                 710                 715                 720 


Asn Lys Glu Ala Tyr Glu Asp Phe Leu Asn Arg Ile Gly Lys Ile Gly 
                725                 730                 735     


Glu Asn Ala Asp Leu Gly Gln Ile Cys Gln Thr Ile Met Thr Asp Tyr 
            740                 745                 750         


Glu Met Gln Asn His Asp Lys Arg Val Lys Lys Gly Asp Ser Arg Asp 
        755                 760                 765             


Leu Gly Ser Tyr Lys His Phe Arg Thr Leu Leu Tyr Ile Phe Ile Arg 
    770                 775                 780                 


Glu Thr Phe Val Glu Tyr Leu Thr Lys Ser Glu Arg Ala Asp Leu Phe 
785                 790                 795                 800 


Ala Phe Ile Arg Glu Pro Ala Arg Leu Asp Pro Glu Pro Gly Glu Glu 
                805                 810                 815     


Asp Phe Cys Ser Gly Trp Thr Cys Thr Met Tyr Asp Gly Ile Leu Glu 
            820                 825                 830         


Glu Glu Glu Lys Arg Glu Met Leu Lys Trp Tyr Val Thr Gly His Phe 
        835                 840                 845             


Leu Thr Pro Lys Gln Leu Asn His Leu Ile Gly Asp Phe Lys Thr Tyr 
    850                 855                 860                 


Ile Trp Tyr Val Arg Asp Ile Glu Arg Arg Ala Ala Asp Thr Lys Asn 
865                 870                 875                 880 


Arg Ser Tyr Pro Asp Arg Ala Glu Asp Lys Ala Ser Leu Ala Met Gln 
                885                 890                 895     


Ile Leu Arg Ile Leu Glu Phe Ala Met Tyr Phe Cys Gly Gln Thr Ser 
            900                 905                 910         


Asn Leu Val Asp Asp Tyr Phe Ser Asp Lys Glu Asp Tyr Ala Gln Thr 
        915                 920                 925             


Leu Ala Glu Val Val Ser Phe Lys Asp Lys His Tyr Pro Asp Cys Arg 
    930                 935                 940                 


Ser Ala Leu Lys Ala Phe Cys Gly Arg Lys Ile Pro Val Thr Leu Thr 
945                 950                 955                 960 


Asp Gly Asn Gly Lys Lys Arg Thr Glu Ala Val Gln Cys Gly Ile Tyr 
                965                 970                 975     


His Asp Gly Met Asn Pro Ile Ala Asn Arg Asn Val Ile Leu Ala Ser 
            980                 985                 990         


Met Tyr Ser Ser Ile Pro Ile Leu  Gly Arg Val Thr Asp  Pro Ile Thr 
        995                 1000                 1005             


Glu Arg  Asp Ile Arg Ala Tyr  Tyr Gln Lys Gln Ala  Asp Asn Ala 
    1010                 1015                 1020             


Lys Tyr  Ile Lys Thr Gly Lys  Cys Asp Ser Lys Glu  Glu Gln Glu 
    1025                 1030                 1035             


Ser Leu  Arg Glu Tyr Gln Asn  Val Lys Asn Arg Thr  Glu Met Asn 
    1040                 1045                 1050             


Asp Leu  Ile Thr Phe Ala Asp  Met Thr Asn Asp Leu  Ile Ser Gln 
    1055                 1060                 1065             


Leu Val  Ser Trp Ala Tyr Phe  Arg Glu Arg Asp Leu  Met Tyr Tyr 
    1070                 1075                 1080             


Gln Leu  Gly Tyr Tyr Tyr Thr  Lys Leu Tyr Tyr Thr  Asp Thr Val 
    1085                 1090                 1095             


Pro Ala  Asp Asp Leu Arg Arg  Lys Leu Thr Gly Lys  Gly Ile His 
    1100                 1105                 1110             


Ile Thr  Asp Gly Ala Ile Leu  Tyr Gln Ile Ala Ala  Leu Tyr Thr 
    1115                 1120                 1125             


Tyr Gly  Leu Pro Val Phe Ser  Val Asn Lys Lys Gly  Glu Ala Glu 
    1130                 1135                 1140             


Ala Pro  Ser Lys Ala Gly Ser  Ser Gln Gly Ala Ser  Val Arg Thr 
    1145                 1150                 1155             


Phe Val  Lys His Tyr Cys His  Glu Ser Met Gln Asp  Ala Pro Thr 
    1160                 1165                 1170             


Tyr Phe  Asp Gly Leu Phe Leu  Phe Glu Asp Ile Ser  Ala His Asp 
    1175                 1180                 1185             


Asp Ile  Ile Ala Cys Arg Asn  Tyr Ile Asp His Phe  Lys Tyr Tyr 
    1190                 1195                 1200             


Ala Gly  Pro Glu Lys Ser Ile  Leu Asp Leu Tyr Ser  Asp Met Tyr 
    1205                 1210                 1215             


Asp Arg  Phe Phe Asp Tyr Ser  Leu Asn Phe Lys Lys  Ser Ile Ser 
    1220                 1225                 1230             


Phe Ile  Leu Pro Asn Ile Leu  Gln Arg Tyr Phe Val  Thr Leu Arg 
    1235                 1240                 1245             


Thr Gly  Val Glu Lys Glu Val  Val Thr Arg Gly Gly  Lys Glu Arg 
    1250                 1255                 1260             


Thr Arg  Ala Arg Ile Lys Val  Lys Asp Ala Val Ser  Asp Lys Leu 
    1265                 1270                 1275             


Thr Tyr  Lys Val Gly Glu Lys  Asp Glu Pro Val Leu  Val Asp Ala 
    1280                 1285                 1290             


Arg Asn  Lys Val Phe Leu Glu  Ser Val Arg Arg Leu  Leu Glu Tyr 
    1295                 1300                 1305             


Arg Ile  Thr Lys 
    1310         


<210>  1137
<211>  1093
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1137

Met Thr Lys Glu Lys Arg Ser Asn Lys Trp Ala Phe Leu Leu Tyr Gln 
1               5                   10                  15      


Glu Ser Ala Pro Glu His Tyr Leu Asp Val Leu Glu Asn Met His Ile 
            20                  25                  30          


Pro Phe Val Leu Ser Pro Trp His Asp Lys Asp Ile Asn Lys Glu Thr 
        35                  40                  45              


Gly Glu Phe Lys Lys Ala His Lys His Gly Ala Leu Tyr Phe Asp Ser 
    50                  55                  60                  


Leu Lys Ser Tyr Ser Gln Val Ser Glu Leu His Asp Leu Leu Leu Lys 
65                  70                  75                  80  


Leu Glu Phe Ile Tyr Val Tyr Lys Leu Thr Asp Ile Leu Glu Ile Pro 
                85                  90                  95      


Asn Cys Ser Asp Asn Ser Asp Arg Leu Leu Glu Phe Ile Ile Leu Cys 
            100                 105                 110         


Arg Gly Ile Glu Glu Ile Leu Phe Phe Phe Trp Asp Val Phe Asp Arg 
        115                 120                 125             


Tyr Trp Asp Asn Phe Phe Glu Tyr Met Tyr Glu Phe Asp Trp Tyr Tyr 
    130                 135                 140                 


Trp Arg Thr Arg Arg Asp Leu Arg Glu Asn Leu Val His Gly Val Leu 
145                 150                 155                 160 


Asp Glu Arg Gly Ile Glu Phe Leu Ile Phe Leu Thr Arg Asn Leu Ser 
                165                 170                 175     


Lys Val Phe Ser Gly Arg Ile Asn Ala Leu Gln Asn Ser Met Leu Ser 
            180                 185                 190         


Leu Asp Gly Ser Leu His Phe Val Asn Ile Arg Asn Thr Arg Ile Phe 
        195                 200                 205             


His Lys Arg Phe Pro Gln Arg Ile Lys Lys Tyr Leu Ser Asn Pro Asp 
    210                 215                 220                 


Asp Lys Ile Tyr Lys Lys Ala Phe Glu Ser Ser Asn Ile Ser Cys Tyr 
225                 230                 235                 240 


Ala Thr Ile Glu Phe Asp Gly Glu Lys Tyr Ile Ala Val Asn Gly Ile 
                245                 250                 255     


Ala Leu Asp Gly Asn Lys Asn Arg Ile Leu Asn Glu Phe Lys Lys Val 
            260                 265                 270         


Leu Glu Ser Phe Asp Lys Lys Ser Val Lys Ile Val Asp Ile Ala Asp 
        275                 280                 285             


Gly Val Arg Tyr Tyr Leu Asn Asp Leu Lys Arg Tyr Ile Glu Tyr Lys 
    290                 295                 300                 


Asp Phe Val Ser Gln Asn Val Asp Lys Lys Asn Arg Arg Met Phe Thr 
305                 310                 315                 320 


Cys Cys Glu Arg Lys Leu Phe Ala Lys Leu Arg Glu Glu Asn Asn Gly 
                325                 330                 335     


Val Glu Ile Lys Asp Ile Ser Thr Arg Gln Lys Ile His Leu Ser Thr 
            340                 345                 350         


Thr Lys Ser Pro Cys Ala Met Cys Gln Arg Glu Ile Lys Val Asn Ser 
        355                 360                 365             


Tyr Lys Ile Phe Glu Met Lys Phe Gln Asn Pro Asn Ile Glu Ser Ser 
    370                 375                 380                 


Asp Asp Leu Glu Ile Leu Lys Ala Glu Glu Thr Phe Leu Asn Lys Leu 
385                 390                 395                 400 


Ser Thr Ala Val Ser Lys Val Gly Tyr Thr Leu Asn Thr Leu Leu Glu 
                405                 410                 415     


Val Asn Pro Glu Lys Asp Ile Leu Glu Lys Tyr Glu Glu Val Glu Lys 
            420                 425                 430         


Leu Cys Thr Asn Asn Ser Ile Lys Asn Leu Cys Thr Val Tyr Ser Glu 
        435                 440                 445             


Ile Asn Asn Asn Glu Lys Leu Leu Lys Gly Met Ile Tyr Phe Ile Gln 
    450                 455                 460                 


Gly Leu Arg Gln Gln Val Leu His Pro Lys Ile Leu Trp Glu Lys Asn 
465                 470                 475                 480 


Val His Lys Ala Glu Lys Val Lys Glu Lys Glu Lys Ile Val Ile Arg 
                485                 490                 495     


Phe Gln Asn Glu Gly Lys Ala Tyr Asn Lys Lys Arg Ile Glu Glu Tyr 
            500                 505                 510         


Phe Glu Asn Ile Leu Glu Lys Ile Pro Asn Tyr Phe Ile Glu Lys Tyr 
        515                 520                 525             


Glu Ser Asn Asn Val Phe Asn Ile Tyr Arg Asn Phe Ile Asp Glu Ile 
    530                 535                 540                 


Phe Glu Ile Ile Asp Lys Phe Asp Phe Lys Glu Ser Asn Ser Ile Ser 
545                 550                 555                 560 


Tyr Leu Phe Pro Lys Phe His Lys Ile Tyr Lys Arg Ile Cys Lys Ser 
                565                 570                 575     


Glu Asn Ile Asn Asp Arg Gln Asn Gly Ala Arg Lys Tyr Leu Leu Gln 
            580                 585                 590         


Thr Ile Tyr Tyr Tyr Tyr Phe Gln Tyr Glu Ile Glu Asn Asn Lys Asn 
        595                 600                 605             


Asp Ile Phe Lys Tyr Leu Asn Leu Tyr Lys Ser Lys Ile Lys Ala Lys 
    610                 615                 620                 


Lys Ile Ser Tyr Ser His Ile Ile Asp Asn Lys Asp Val Asn Asn Lys 
625                 630                 635                 640 


Asn Ile Glu Ile Leu Tyr Arg Asn Ile Gln Arg Glu Gly Met Leu Asn 
                645                 650                 655     


Asn Arg Leu Leu Gln Met Asn Asn Glu Trp Ile Glu Phe Met Val Val 
            660                 665                 670         


Gln Phe Ser Glu Phe Leu Thr Asn Lys Lys Leu Asn Trp Ile Leu Asp 
        675                 680                 685             


Asp Leu Ser Glu Tyr Lys Lys Lys Glu Lys Leu Asp Glu Asn Asp Lys 
    690                 695                 700                 


Asn Lys Leu Leu Lys Thr Leu Lys Gln Lys Met Asn Lys Lys Ile Thr 
705                 710                 715                 720 


Tyr Ser Asn Asp Ser Tyr Val Phe Ile Ser Leu Ala Gln Phe Leu Asp 
                725                 730                 735     


Leu Lys Glu Ile Ser Asn Leu Ile His Asp Ile Lys Lys Phe Ile Gln 
            740                 745                 750         


Phe Arg Glu Lys Asn Val Ser Lys Tyr Lys Pro Glu Lys Asn Lys Leu 
        755                 760                 765             


Tyr Ile Lys Glu Leu Arg Lys Val Leu Tyr Ile Leu Lys Val Met Leu 
    770                 775                 780                 


Glu His Lys Glu Arg Val Ile Gln Lys His Tyr Leu Glu Ser Tyr Asp 
785                 790                 795                 800 


Glu Asn Ile Ser Ile Ile Tyr Gly Lys Asp Ile Glu Arg Lys Asp Ile 
                805                 810                 815     


Lys Asp Ile Lys Ile Lys Ile Lys Asn Glu Asn Gln Glu Val Ile Asn 
            820                 825                 830         


Gln Pro Leu Tyr Lys Ser Gly Asn Asp Glu Asn Ser Ser Trp Ile Val 
        835                 840                 845             


Leu Tyr Gly Ile Glu Gln Ala Lys Arg Asn Gly Thr Phe Lys Phe Phe 
    850                 855                 860                 


Glu Gly Phe Phe Asn Leu Asn Asp Asp Ile Lys Leu Cys Lys Glu Asn 
865                 870                 875                 880 


Ile Glu Lys Tyr Glu Glu Leu Tyr Asn Glu Lys Glu Glu Asn Gln Arg 
                885                 890                 895     


Lys Val Asp Glu Tyr Ile Ser Ser Glu Glu Asn Asn Asn Ile Asp Glu 
            900                 905                 910         


Ile Glu Glu Ile Asn Asn Asn Lys Gln Leu Phe Tyr Tyr Tyr Lys Asn 
        915                 920                 925             


Met Ile Tyr Gly Asp Gly Leu Lys Lys Gly Tyr Asp Phe Ile Asn Asp 
    930                 935                 940                 


Ile Tyr Ser His Tyr Leu Ser Trp Ala Tyr Arg Val Glu Arg Asp Cys 
945                 950                 955                 960 


Lys Ile Tyr Lys Ile Lys Glu Tyr Glu Asn Lys Lys Asn Phe Asn Glu 
                965                 970                 975     


Tyr Lys Phe Lys Glu Tyr Lys Ser Ile Lys Asn Phe Arg Asn Glu Ile 
            980                 985                 990         


Ala His Phe Asn Tyr Phe Gln Lys  Thr Asn Lys Ser Leu  Leu Glu Leu 
        995                 1000                 1005             


Leu Asn  Asp Phe Tyr Asp Ile  Phe Asp Tyr Asn Leu  Lys Tyr Gln 
    1010                 1015                 1020             


Arg Asp  Val Gln Lys Val Ile  Asn Asn Ile Phe Glu  Lys Tyr Gln 
    1025                 1030                 1035             


Ile Val  Arg Lys Asp Arg Gly  Pro Val Val Phe Tyr  Cys Lys Thr 
    1040                 1045                 1050             


Asp Lys  Lys Leu Lys Leu Ser  Glu Asn Ile Ile Pro  Lys Lys His 
    1055                 1060                 1065             


Leu Lys  Tyr Pro Glu Ile Lys  Leu Ile His Glu Lys  Tyr Val Glu 
    1070                 1075                 1080             


Phe Phe  Lys Lys Leu Phe Glu  Tyr Lys Lys 
    1085                 1090             


<210>  1138
<211>  1184
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1138

Met Arg Val Ser Lys Val Lys Val Leu Gly Asn Glu Glu Thr Lys Gly 
1               5                   10                  15      


Arg Ile Val Leu Met His Arg Ser Pro Val Lys Gly Gln Leu Ile Tyr 
            20                  25                  30          


Ser Glu Asp Ala Gly Lys Arg Asp Arg Thr Glu Asp Ile Ile Pro Glu 
        35                  40                  45              


Gln Lys Leu Glu Ser Phe His Leu Ser Ile Leu Asn Lys Thr Phe Leu 
    50                  55                  60                  


Arg Lys Glu Phe Phe Lys Lys Glu Leu Lys His Glu Ala Lys Lys Asn 
65                  70                  75                  80  


Gly Leu Lys Gly Asp Ala Glu Asp Lys Tyr Ile Ser Glu Lys Leu Lys 
                85                  90                  95      


Glu Tyr His Ser Leu Leu Gln Phe Ile Asp Asp Val Leu Ser Val Lys 
            100                 105                 110         


Tyr Asn Glu Asn Arg Lys Ala Ile Lys Phe Pro Glu Tyr Leu Thr Arg 
        115                 120                 125             


Glu Met Ile Glu Ile Phe Leu Asn His Lys Phe Arg Lys Glu Val Thr 
    130                 135                 140                 


Tyr Thr Asn Lys Asn Gly Ala Ser Val Ser Phe Leu Leu Ser Thr Leu 
145                 150                 155                 160 


Ile Leu Asn Ala Ile Glu Lys His Ser Val Ile Glu Met Gln Pro Phe 
                165                 170                 175     


Val Asp Trp Arg Asn Trp Phe Val Glu Thr Lys Ser Lys Phe Leu Lys 
            180                 185                 190         


Lys Ser Ile Ile Asn Asn Cys Ile Pro Thr Asn Gly Gly Pro Ile Ser 
        195                 200                 205             


Arg Arg Arg Glu Thr Leu Met Lys Trp Arg Asp Asp Tyr Phe Thr Asn 
    210                 215                 220                 


Ala Glu Ile Asp Leu Ala Arg Leu His Lys Lys Phe Gly Thr Asp Thr 
225                 230                 235                 240 


Leu Met Ala Ser Leu Arg Glu Val Pro Gln Thr Glu Lys Ser Gly Asn 
                245                 250                 255     


Glu Tyr His Arg Leu Leu Lys Ser Cys Leu Gln Ser His Gln Lys Lys 
            260                 265                 270         


Leu Phe Gly Lys Arg Ala Glu Gly Tyr Asp Ile Asn Arg Ala Asp Asn 
        275                 280                 285             


Gln Leu Tyr Val Tyr Asn Thr Glu Val Val Lys Tyr Met Glu His Tyr 
    290                 295                 300                 


Phe Pro Val Lys Ser Ser Lys Arg Arg Asn Ser Thr Ala Glu Ile Lys 
305                 310                 315                 320 


Tyr Tyr Leu Gln Thr Asp Thr Ile Lys Cys Cys Leu His His Gln Ile 
                325                 330                 335     


Ile Asn Ala Val Arg Gly Leu Ala Leu Arg Glu Gly Lys Phe Asn Leu 
            340                 345                 350         


His Gly Phe Asp Asp Lys Leu Ile Pro Asn Glu Arg Asn Val Ser Ser 
        355                 360                 365             


Ser Ile Leu Asn Glu Leu Lys Thr Ser Glu Gly Phe Val Leu Asn Met 
    370                 375                 380                 


Leu Gly Gly Cys Ala Phe Ala Ala Asn Cys Leu Arg Asn Ile Val Asp 
385                 390                 395                 400 


Ala Thr Gln Arg Ser Asp Leu Leu Gly Phe Arg Cys Phe Glu Val Ser 
                405                 410                 415     


Leu Lys Lys Gly Lys Ser Asn Ser Asp Leu Phe Ala Leu Phe Phe Gly 
            420                 425                 430         


Phe Gly Arg Glu Asp Met Asp Asp Asp Ser Glu Trp Glu Lys His Leu 
        435                 440                 445             


Tyr Ala Ala Arg Tyr Ser Val Ser Glu Ile Arg Asn Arg Val Ala His 
    450                 455                 460                 


Tyr His Lys Ser Ala Ile Glu Asn Ile Tyr Asn Ile Thr Asp Phe Glu 
465                 470                 475                 480 


Tyr Arg Glu Asn Ser Met Cys Ser Tyr Thr Asp Thr Lys Phe Thr Thr 
                485                 490                 495     


Ala Leu Gln Asn Glu Ile Tyr Asn Thr Pro Lys Ala Phe Ser Leu Gln 
            500                 505                 510         


Leu Met Thr Gly Lys Val Leu Glu Tyr Tyr Pro Lys Glu Lys Leu Val 
        515                 520                 525             


Ser Phe Phe Gln Lys Tyr Lys Phe Ser Leu Tyr Arg Ser Val Val Pro 
    530                 535                 540                 


Phe Ala Pro Gly Phe Lys Asn Ile Met Arg Thr Gly Val Asn Tyr Gln 
545                 550                 555                 560 


Asn Ala Thr Gln Asn Ser Leu Phe Tyr Asp Met Gly Leu Thr Ala Phe 
                565                 570                 575     


Gln Asp Lys Asp Arg Tyr Ile Asp Asp Val Glu Ala Trp Asn Ala Arg 
            580                 585                 590         


Tyr Phe Phe Met Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Arg Phe 
        595                 600                 605             


Thr Asn Asp Lys Asn Asp Leu Phe Arg Lys Thr Val Glu Gln Val Leu 
    610                 615                 620                 


Glu Val Asn Arg Ser His Met Glu Lys Val Gly Lys Asp Asp Arg Lys 
625                 630                 635                 640 


Ala Phe Gly Glu Val Arg Gln Met Arg Glu Asn Glu Thr Ala Asn Asp 
                645                 650                 655     


Tyr Met Ala Tyr Leu Gln Ser Ser Leu Arg Met Glu Lys Asn Lys Lys 
            660                 665                 670         


Glu Leu Glu Gly Asn Gly Ala Lys Arg Ile Asn Phe Glu Lys Phe Ile 
        675                 680                 685             


Leu Gln Met Phe Val Lys Gly Phe Asp Ser Phe Leu Lys Asp Gly Ala 
    690                 695                 700                 


Phe Glu Phe Val His Ser Pro Glu Asn Cys Leu Thr Gly Ser Thr Glu 
705                 710                 715                 720 


Lys Glu Arg Ala Lys Glu Arg Asn Ser Leu Cys Glu Glu Ile Gly Asn 
                725                 730                 735     


Tyr Val Arg Leu Val Ser Thr Val Ile Asp Pro Gly Lys Gly Ser His 
            740                 745                 750         


Val Ala Phe Tyr Val Phe Cys Lys Met Leu Asn Ser Val Tyr Leu Ser 
        755                 760                 765             


Asn Ile Arg Asn Glu Met Ile Lys Tyr His Lys Val Val Arg Thr Asp 
    770                 775                 780                 


Glu Leu Ala His Leu Ile Glu Ile Ile Glu Leu Cys Leu Leu Ser Ala 
785                 790                 795                 800 


Asp Ala Val Ser Gln Lys Thr Val Asn Ala Asp Lys Leu Ser His Phe 
                805                 810                 815     


Phe Ala Glu Gly Val Asn Val Asp Asp Asp Glu Asn Val Ile His Ala 
            820                 825                 830         


Ser Met Glu Thr Phe Arg Lys Tyr Gly Thr Arg Asp Leu Phe His Lys 
        835                 840                 845             


Leu Met Leu Gln Asp Asp Arg Phe Leu Val Ser Ser Asp Asp Tyr Arg 
    850                 855                 860                 


Glu Trp Glu Glu Met Lys Glu Lys Ile Glu Gly Lys Val Lys Gln Arg 
865                 870                 875                 880 


Glu Leu Leu His Ala Glu Trp Cys Glu Ala Lys Glu Lys Asp Lys Lys 
                885                 890                 895     


Ser Arg Lys Val Lys Ser Asn Ser Arg Thr Cys Phe Glu Lys Lys Phe 
            900                 905                 910         


Met Gly Ala Lys Ala Glu Glu Tyr Tyr Ser Leu Cys Lys Val Ile Asp 
        915                 920                 925             


Lys Tyr Asn Trp Leu Asp Asn Lys Leu His Leu Val His Leu Asn Lys 
    930                 935                 940                 


Leu His Asn Leu Val Ile Glu Ile Leu Gly Arg Met Val Gly Phe Thr 
945                 950                 955                 960 


Ala Leu Phe Glu Arg Asp Phe Gln Tyr Ile Cys Lys Ser Asp Ser Glu 
                965                 970                 975     


Tyr Glu Gln Leu Tyr Asn Leu Asp Phe Asn Met Gly Leu Pro Lys Phe 
            980                 985                 990         


Lys Asn Ser Ile Lys Gly Ser Gly  Lys Ala Lys Asn Ser  Thr Gln Asn 
        995                 1000                 1005             


Ile Asp  His Asn Ala Thr Gly  Ile Gly Asn Ser Ser  Asn Leu Leu 
    1010                 1015                 1020             


Lys Glu  Asn Ser Asn Gly Thr  His Tyr Cys Lys Asn  Leu Ser Gly 
    1025                 1030                 1035             


Asp Gly  Val Glu Asp Lys Leu  Lys Arg Leu Phe Leu  Tyr Asp Asp 
    1040                 1045                 1050             


Tyr Arg  Asn Val Arg Asn Phe  Val Ala His Phe Asn  Tyr Leu Thr 
    1055                 1060                 1065             


Arg Val  Glu Asp Asp Leu Gly  Gly Asn Asp Ala Val  Lys Leu Ser 
    1070                 1075                 1080             


Gly Thr  Arg Tyr Ser Leu Ile  Glu Leu Ile Asn Glu  Leu Arg Asn 
    1085                 1090                 1095             


Leu Leu  Lys Tyr Asp Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ser 
    1100                 1105                 1110             


Phe Ile  Asp Met Phe Glu Arg  His Gly Met His Val  Lys Met Lys 
    1115                 1120                 1125             


Leu Asn  His Asn His Lys Leu  Phe Val Asp Ser Ile  Ser Pro Arg 
    1130                 1135                 1140             


Lys Ile  Lys His Leu Gly Gly  Gly Tyr Lys Lys Arg  Gly Lys Asp 
    1145                 1150                 1155             


Asp Lys  Met Tyr Val Gln Thr  Thr Asn His Val Asp  Pro Leu Tyr 
    1160                 1165                 1170             


Cys Asp  Met Cys Arg Ala Leu  Leu Glu Met Lys 
    1175                 1180                 


<210>  1139
<211>  1240
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (925)..(1010)
<223>  Xaa can be any naturally occurring amino acid

<400>  1139

Met Arg Val Ser Lys Val Lys Val Leu Gly Asn Glu Glu Thr Lys Gly 
1               5                   10                  15      


Arg Ile Val Leu Met His Arg Ser Pro Val Lys Gly Gln Leu Ile Tyr 
            20                  25                  30          


Ser Glu Asp Ala Gly Lys Arg Asp Arg Thr Glu Asp Ile Ile Pro Glu 
        35                  40                  45              


Gln Lys Leu Glu Ser Phe His Leu Ser Ile Leu Asn Lys Thr Phe Leu 
    50                  55                  60                  


Arg Lys Glu Phe Phe Lys Lys Glu Leu Lys His Glu Ala Lys Lys Asn 
65                  70                  75                  80  


Gly Leu Lys Gly Asp Ala Glu Asp Lys Tyr Ile Ser Glu Lys Leu Lys 
                85                  90                  95      


Glu Tyr His Ser Leu Leu Gln Phe Ile Asp Asp Val Leu Ser Val Lys 
            100                 105                 110         


Tyr Asn Glu Asn Arg Lys Ala Ile Lys Phe Pro Glu Tyr Leu Thr Arg 
        115                 120                 125             


Glu Met Ile Glu Ile Phe Leu Asn His Lys Phe Arg Lys Glu Val Thr 
    130                 135                 140                 


Tyr Thr Asn Lys Asn Gly Ala Ser Val Ser Phe Leu Leu Ser Thr Leu 
145                 150                 155                 160 


Ile Leu Asn Ala Ile Glu Lys His Ser Val Ile Glu Met Gln Pro Phe 
                165                 170                 175     


Val Asp Trp Arg Asn Trp Phe Val Glu Thr Lys Ser Lys Phe Leu Lys 
            180                 185                 190         


Lys Ser Ile Ile Asn Asn Cys Ile Pro Thr Asn Gly Gly Pro Ile Ser 
        195                 200                 205             


Arg Arg Arg Glu Thr Leu Met Lys Trp Arg Asp Asp Tyr Phe Thr Asn 
    210                 215                 220                 


Ala Glu Ile Asp Leu Ala Arg Leu His Lys Lys Phe Gly Thr Asp Thr 
225                 230                 235                 240 


Leu Met Ala Ser Leu Arg Glu Val Pro Gln Thr Glu Lys Ser Gly Asn 
                245                 250                 255     


Glu Tyr His Arg Leu Leu Lys Ser Cys Leu Gln Ser His Gln Lys Lys 
            260                 265                 270         


Leu Phe Gly Lys Arg Ala Glu Gly Tyr Asp Ile Asn Arg Ala Asp Asn 
        275                 280                 285             


Gln Leu Tyr Val Tyr Asn Thr Glu Val Val Lys Tyr Met Glu His Tyr 
    290                 295                 300                 


Phe Pro Val Lys Ser Ser Lys Arg Arg Asn Ser Thr Ala Glu Ile Lys 
305                 310                 315                 320 


Tyr Tyr Leu Gln Thr Asp Thr Ile Lys Cys Cys Leu His His Gln Ile 
                325                 330                 335     


Ile Asn Ala Val Arg Gly Leu Ala Leu Arg Glu Gly Lys Phe Asn Leu 
            340                 345                 350         


His Gly Phe Asp Asp Lys Leu Ile Pro Asn Glu Arg Asn Val Ser Ser 
        355                 360                 365             


Ser Ile Leu Asn Glu Leu Lys Thr Ser Glu Gly Phe Val Leu Asn Met 
    370                 375                 380                 


Leu Gly Gly Cys Ala Phe Ala Ala Asn Cys Leu Arg Asn Ile Val Asp 
385                 390                 395                 400 


Ala Thr Gln Arg Ser Asp Leu Leu Gly Phe Arg Cys Phe Glu Val Ser 
                405                 410                 415     


Leu Lys Lys Gly Lys Ser Asn Ser Asp Leu Phe Ala Leu Phe Phe Gly 
            420                 425                 430         


Phe Gly Arg Glu Asp Met Asp Asp Asp Ser Glu Trp Glu Lys His Leu 
        435                 440                 445             


Tyr Ala Ala Arg Tyr Ser Val Ser Glu Ile Arg Asn Arg Val Ala His 
    450                 455                 460                 


Tyr His Lys Ser Ala Ile Glu Asn Ile Tyr Asn Ile Thr Asp Phe Glu 
465                 470                 475                 480 


Tyr Arg Glu Asn Ser Met Cys Ser Tyr Thr Asp Thr Lys Phe Thr Thr 
                485                 490                 495     


Ala Leu Gln Asn Glu Ile Tyr Asn Thr Pro Lys Ala Phe Ser Leu Gln 
            500                 505                 510         


Leu Met Thr Gly Lys Val Leu Glu Tyr Tyr Pro Lys Glu Lys Leu Val 
        515                 520                 525             


Ser Phe Phe Gln Lys Tyr Lys Phe Ser Leu Tyr Arg Ser Val Val Pro 
    530                 535                 540                 


Phe Ala Pro Gly Phe Lys Asn Ile Met Arg Thr Gly Val Asn Tyr Gln 
545                 550                 555                 560 


Asn Ala Thr Gln Asn Arg Leu Phe Tyr Asp Met Gly Leu Thr Ala Phe 
                565                 570                 575     


Gln Asp Lys Asp Arg Tyr Ile Asp Asp Val Glu Ala Trp Asn Ala Arg 
            580                 585                 590         


Tyr Phe Phe Met Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Arg Phe 
        595                 600                 605             


Thr Asn Asp Lys Asn Asp Leu Phe Arg Lys Thr Val Glu Gln Val Leu 
    610                 615                 620                 


Glu Val Asn Arg Ser His Met Glu Lys Val Gly Lys Asp Asp Arg Gln 
625                 630                 635                 640 


Ala Phe Gly Glu Val Arg Gln Met Arg Glu Asn Glu Thr Ala Asn Asp 
                645                 650                 655     


Tyr Met Ala Tyr Leu Gln Ser Ser Leu Arg Met Glu Lys Asn Lys Lys 
            660                 665                 670         


Glu Leu Glu Gly Asn Gly Ala Lys Arg Ile Asn Phe Glu Lys Phe Ile 
        675                 680                 685             


Leu Gln Met Phe Val Lys Gly Phe Asp Ser Phe Leu Lys Asp Gly Ala 
    690                 695                 700                 


Phe Glu Phe Val His Ser Pro Glu Asn Cys Leu Thr Gly Ser Thr Glu 
705                 710                 715                 720 


Lys Glu Arg Ala Lys Glu Arg Asn Ser Leu Cys Glu Glu Ile Gly Asn 
                725                 730                 735     


Tyr Val Arg Leu Val Ser Thr Val Ile Asp Pro Gly Lys Gly Ser His 
            740                 745                 750         


Val Ala Phe Tyr Val Phe Cys Lys Met Leu Asn Ser Val Tyr Leu Ser 
        755                 760                 765             


Asn Ile Arg Asn Glu Met Ile Lys Tyr His Lys Val Val Arg Thr Asp 
    770                 775                 780                 


Glu Leu Ala His Leu Ile Glu Ile Ile Glu Leu Cys Leu Leu Ser Ala 
785                 790                 795                 800 


Asp Ala Val Ser Gln Lys Thr Val Asn Ala Asp Lys Leu Ser His Phe 
                805                 810                 815     


Phe Ala Glu Gly Val Asn Val Asp Asp Asp Glu Asn Val Ile His Ala 
            820                 825                 830         


Ser Met Glu Thr Phe Arg Lys Tyr Gly Thr Arg Asp Leu Phe His Lys 
        835                 840                 845             


Leu Met Leu Gln Asp Asp Arg Phe Leu Val Ser Ser Asp Asp Tyr Arg 
    850                 855                 860                 


Glu Trp Glu Glu Met Lys Glu Lys Ile Glu Gly Lys Val Lys Gln Arg 
865                 870                 875                 880 


Glu Leu Leu His Ala Glu Trp Cys Glu Ala Lys Glu Lys Asp Lys Lys 
                885                 890                 895     


Ser Arg Lys Val Lys Ser Asn Ser Arg Thr Cys Phe Glu Lys Lys Phe 
            900                 905                 910         


Met Gly Ala Lys Ala Glu Glu Tyr Tyr Ser Leu Cys Xaa Xaa Xaa Xaa 
        915                 920                 925             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    930                 935                 940                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
945                 950                 955                 960 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                965                 970                 975     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            980                 985                 990         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
        995                 1000                 1005             


Xaa Xaa  Arg Met Val Gly Phe  Thr Ala Leu Phe Glu  Arg Asp Phe 
    1010                 1015                 1020             


Gln Tyr  Ile Cys Lys Ser Asp  Ser Glu Tyr Glu Gln  Leu Tyr Asn 
    1025                 1030                 1035             


Leu Asp  Phe Asn Met Gly Leu  Pro Lys Phe Lys Asn  Ser Ile Lys 
    1040                 1045                 1050             


Gly Ser  Gly Lys Ala Lys Asn  Ser Thr Gln Asn Ile  Asp His Asn 
    1055                 1060                 1065             


Ala Thr  Gly Ile Gly Asn Ser  Ser Asn Leu Leu Lys  Glu Asn Ser 
    1070                 1075                 1080             


Asn Gly  Thr His Tyr Cys Lys  Asn Leu Ser Gly Asp  Gly Val Glu 
    1085                 1090                 1095             


Asp Lys  Leu Lys Arg Leu Phe  Leu Tyr Asp Asp Tyr  Arg Asn Val 
    1100                 1105                 1110             


Arg Asn  Phe Val Ala His Phe  Asn Tyr Leu Thr Arg  Val Glu Asp 
    1115                 1120                 1125             


Asp Leu  Gly Gly Asn Asp Ala  Val Lys Leu Ser Gly  Thr Arg Tyr 
    1130                 1135                 1140             


Ser Leu  Ile Glu Leu Ile Asn  Glu Leu Arg Asn Leu  Leu Lys Tyr 
    1145                 1150                 1155             


Asp Arg  Lys Leu Lys Asn Ala  Val Ser Lys Ser Phe  Ile Asp Met 
    1160                 1165                 1170             


Phe Glu  Arg His Gly Met His  Val Lys Met Lys Leu  Asn His Asn 
    1175                 1180                 1185             


His Lys  Leu Phe Val Asp Ser  Ile Ser Pro Arg Lys  Ile Lys His 
    1190                 1195                 1200             


Leu Gly  Gly Gly Tyr Lys Lys  Arg Gly Lys Asp Asp  Lys Met Tyr 
    1205                 1210                 1215             


Val Gln  Thr Thr Asn His Val  Asp Pro Leu Tyr Cys  Asp Met Cys 
    1220                 1225                 1230             


Arg Ala  Leu Leu Glu Met Lys  
    1235                 1240 


<210>  1140
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1140

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Ile Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Asp Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Tyr Leu Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Lys Asn Tyr Lys Trp Arg Glu Ser Cys 
                85                  90                  95      


Ser Glu Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Thr 
        115                 120                 125             


Lys Asp Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Glu Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Gly Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Glu Thr Gly Leu Leu Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Thr Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Ile Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Lys Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  1141
<211>  1284
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1141

Met Ile Ile Gly Gly Ile Asn Met Lys Leu Thr Arg Arg Arg Ile Ser 
1               5                   10                  15      


Gln Glu Arg Lys Asn Gln Lys Leu Thr Ala Ala Phe Tyr Arg Asp Met 
            20                  25                  30          


Asp His Gly Leu Leu Tyr Val Asp Ser Glu Asp Glu Asp Arg Thr Glu 
        35                  40                  45              


Tyr Val Val Ser Ser Met Asp Phe Glu Arg Ser Trp Arg Gly Arg Ile 
    50                  55                  60                  


Leu Lys Asn Gly Glu Asp Asn Lys Asn Pro Phe Tyr Glu Phe Val Lys 
65                  70                  75                  80  


Gly Leu Val Gly Ser Asn Glu Ile Ile Cys Lys Pro Ile Thr Asn Asp 
                85                  90                  95      


Asn Asn Thr Asp Ile Asn Glu Lys Ile Lys Lys Tyr Ile Thr Glu Phe 
            100                 105                 110         


Gly Arg Asn Leu Lys Ala Pro Gly Ser Glu Val Thr Leu Glu Lys Leu 
        115                 120                 125             


Ile Leu Asn Ile Gln Ser Gly Thr Ser Glu Asn Glu Val Arg Pro Glu 
    130                 135                 140                 


Leu Glu Lys Ile Lys Asp Met Ile Lys Lys Asp Ile Glu Lys Arg Lys 
145                 150                 155                 160 


Asp Glu Leu Ile Lys Ser Ile Thr Asn Asn His Ile Pro Phe Met Leu 
                165                 170                 175     


Asp Glu Asp Lys Leu Val Pro Ser Thr Lys Lys Met Lys Trp Leu Tyr 
            180                 185                 190         


Lys Phe Leu Asn Gly Pro Asp Lys Ser Leu Asn Leu Gln Met Phe Asp 
        195                 200                 205             


Glu Tyr Trp Ile Lys Tyr Gly Tyr Lys Asn Leu Glu Glu Lys Ile Ile 
    210                 215                 220                 


Lys Glu Ile Asn Ser Leu Pro Glu Lys Asn Ala Arg Ser Ile Ser Arg 
225                 230                 235                 240 


Ala Val Ser Lys Thr Val Arg Glu Tyr Asn Arg Asn Phe Arg Ile Asn 
                245                 250                 255     


Tyr Met Val Pro Glu Asn Glu Asn Ala Glu Ala Asp Ser Asp Tyr Glu 
            260                 265                 270         


Gly Phe Leu Leu Phe Leu Lys Ala Val Glu Gln His Phe Lys Lys Tyr 
        275                 280                 285             


Tyr Pro Val Lys Ser Lys Asp Ser Ser Glu Val Arg Asp Lys Asn Leu 
    290                 295                 300                 


Cys Glu Glu Lys Asn Tyr Lys Phe Tyr Cys Ser Tyr Asn Phe Val Lys 
305                 310                 315                 320 


Asn Glu Val Lys Arg Ser Ile Ile Asn Gln Leu Val Ser Gly Leu Ile 
                325                 330                 335     


Gln Gln Gly Lys Leu Leu His Tyr Phe Tyr Lys Asp Gly Ile Trp Gln 
            340                 345                 350         


Gln Asp Phe Leu Asn Ser Tyr Gly Leu Ser Tyr Ile Gln Val Glu Glu 
        355                 360                 365             


Ser Phe Lys Lys Ser Leu Met Thr Ser Leu Ser Trp Gly Ile Asn Arg 
    370                 375                 380                 


Leu Thr Ser Phe Phe Ile Asp Val Gly Thr Asp Glu Asn Glu Glu Lys 
385                 390                 395                 400 


Thr Val Gln Asn Lys Lys Gln Lys Asn Asn Arg Lys Ile Asp Asp Ile 
                405                 410                 415     


Leu Ser Asp Lys Ser Asn Leu Arg Ala Ile Phe Asn Asp Leu Arg Ser 
            420                 425                 430         


Asn Thr Glu Leu Gln Lys His Phe Lys Glu Lys Leu Ala Phe Cys Tyr 
        435                 440                 445             


Pro Ile Phe Ile Lys Val Lys Lys Glu Lys Met Phe Asp Asp Ile Glu 
    450                 455                 460                 


Lys Leu Ile Lys Leu Val Glu Glu Ala Arg Glu Ser Val Ala Tyr Leu 
465                 470                 475                 480 


Arg His Arg Cys Phe His Tyr Lys Asp Val Thr Ile Thr Glu Met Leu 
                485                 490                 495     


Lys Ala Leu Asn Asn Asn Thr Glu Thr Asp Lys Thr Glu Asp Ile Asp 
            500                 505                 510         


Tyr Ser Val Ala Ala Glu Tyr Phe Leu Arg Asp Ile Asn Asn Leu Tyr 
        515                 520                 525             


Asp Ala Phe Arg Glu Gln Ile Arg Ser Ser Gly Ile Ala Asp Tyr Tyr 
    530                 535                 540                 


Pro Ala Asp Ile Ile Ser Gly Cys Phe Lys Lys Cys Gly Leu Gln Phe 
545                 550                 555                 560 


Val Leu Tyr Ser Pro Gln Asn Ser Leu Met Pro Ser Phe Lys Asn Ile 
                565                 570                 575     


Tyr Lys Arg Gly Ser Asn Leu Tyr Lys Ala Tyr Gln Glu Glu Lys Glu 
            580                 585                 590         


Gln Lys Asp Lys Glu Tyr Lys Arg His Asn Thr Asn Ile Val Gln Glu 
        595                 600                 605             


Glu Ser Lys Glu Leu Ser Trp Tyr Ile Glu Val Ser Asp Thr Glu Gln 
    610                 615                 620                 


Gly Lys Thr Ala Tyr Arg Asn Leu Leu Gln Leu Ile Tyr Tyr His Ala 
625                 630                 635                 640 


Phe Leu Pro Glu Val Arg Glu Asn Glu Ser Leu Ile Thr Val Tyr Phe 
                645                 650                 655     


Ala Lys Thr Lys Glu Trp Asn Arg Lys Val Ala Glu Thr Lys Ala Lys 
            660                 665                 670         


Lys Lys Asn Ala Gly Lys Thr Tyr Lys Asp Lys Pro Ile Arg Ala Tyr 
        675                 680                 685             


Arg Tyr Glu Ala Ile Pro Asp Tyr Val Gly Glu Arg Leu Asp Asp Tyr 
    690                 695                 700                 


Phe Lys Ile Leu Gln Arg Glu Gln Met Ala Lys Ala Lys Asp Val Asn 
705                 710                 715                 720 


Glu Gly Asn Ala Glu Asn Asn Asn Tyr Ile Gln Phe Ile Arg Asp Val 
                725                 730                 735     


Val Val Trp Ala Phe Gly Ala Tyr Leu Glu Glu Arg Leu Glu Lys Tyr 
            740                 745                 750         


Lys Lys Asp Leu Gln Ser Ser His Ser Gln Lys Asp Lys Lys Asp Val 
        755                 760                 765             


Asn Asp Ala Leu Lys Glu Leu Phe Pro Asp Asp Lys Asp Lys Arg Gln 
    770                 775                 780                 


Phe Phe Met Lys Cys Lys Phe Thr Asp Val Leu Ile Asn Asp Val Gly 
785                 790                 795                 800 


Glu Asn Asn Gln Ile Thr Glu Met Glu Asp Leu Glu Thr Ser Lys Glu 
                805                 810                 815     


Gln Gln Asn Arg Glu Ile Lys Arg Lys Asp Leu Leu Cys Phe Tyr Leu 
            820                 825                 830         


Phe Leu Arg Leu Leu Asp Glu Arg Glu Ile Ser Gly Leu Lys His Gln 
        835                 840                 845             


Phe Val Arg Tyr Arg Cys Ser Leu Lys Glu Arg Arg Leu Pro Asp Asn 
    850                 855                 860                 


Arg Lys Asp Val Asp Glu Glu Ile Val Leu Leu Glu Glu Leu Glu Glu 
865                 870                 875                 880 


Leu Met Glu Leu Val Ser Tyr Thr Met Pro Ser Val Pro Glu Leu Ser 
                885                 890                 895     


Gly Lys Ala Glu Ser Gly Leu Asp Leu Val Ile Ser Lys Tyr Phe Lys 
            900                 905                 910         


Asp Phe Phe Glu Lys Ser Ala Leu Lys Asn Gln Asp Ile Met Lys Leu 
        915                 920                 925             


Tyr Tyr Gln Ser Asp Asn Lys Thr Pro Val Phe Arg Lys Tyr Met Ala 
    930                 935                 940                 


Leu Leu Met Arg Ser Ala Pro Leu Gln Leu Tyr Lys Asp Met Phe Arg 
945                 950                 955                 960 


Asn Tyr Tyr Ile Ile Thr Glu Lys Glu Cys Gln Glu Tyr Ile Lys Thr 
                965                 970                 975     


Ser Gln Asp Ile Asp Ala Phe Gln Cys Lys Leu Asn Glu Leu His Lys 
            980                 985                 990         


Glu Leu Glu His Val Arg Leu Lys  Thr Val Glu Asp Lys  Lys Gly Lys 
        995                 1000                 1005             


Ile Phe  Tyr Tyr Leu Ala Gly  Ser Asp Ala Glu Arg  Val Lys Glu 
    1010                 1015                 1020             


Tyr Glu  Asp Thr Leu Ser Lys  Val Val Arg Tyr Lys  Arg Leu Gln 
    1025                 1030                 1035             


His Lys  Leu Thr Phe Glu Ser  Leu Tyr Thr Ile Phe  Lys Ile His 
    1040                 1045                 1050             


Val Asp  Ile Ala Ala Arg Met  Val Gly Tyr Thr Glu  Asp Trp Glu 
    1055                 1060                 1065             


Arg Asp  Met Leu Phe Leu Phe  Lys Ser Leu Glu Tyr  Asn Glu Lys 
    1070                 1075                 1080             


Leu Asn  Glu Gly Val Val Glu  Lys Ile Phe Asn Asn  Lys Asp Glu 
    1085                 1090                 1095             


Lys Gly  His Ile Val Lys Lys  Leu Lys Asp Asn Leu  Asn Ser Glu 
    1100                 1105                 1110             


Asp Lys  Glu Lys Ile Glu Ile  Leu Cys Trp His Lys  Glu Ile Thr 
    1115                 1120                 1125             


Asp Lys  Asn Phe Val Glu Ile  Ile Trp Ile Arg Asn  Pro Ile Ala 
    1130                 1135                 1140             


His Leu  Asn His Phe Met Gln  Thr Val Lys Asn Pro  Lys Arg Ser 
    1145                 1150                 1155             


Leu Glu  Lys Met Ile Asn Ala  Leu Cys Val Leu Leu  Ser Tyr Asp 
    1160                 1165                 1170             


Arg Lys  Arg Gln Asn Ser Val  Thr Lys Thr Ile Asn  Asp Leu Leu 
    1175                 1180                 1185             


Leu Asn  Glu Tyr His Val Lys  Ile Lys Trp Lys Arg  Trp Val Asp 
    1190                 1195                 1200             


Lys Asn  Cys Asn Ile Tyr Tyr  Tyr Ile Asp Glu Gln  Asn Ile Glu 
    1205                 1210                 1215             


Asn Glu  Pro Ile Leu His Ile  Lys His Leu His Met  Gly Glu Lys 
    1220                 1225                 1230             


Cys His  Val Asn Arg Asn Ala  Asp Met Phe Asp Arg  Gln Lys Glu 
    1235                 1240                 1245             


Trp Leu  Arg Asn Gly Ile Thr  Glu Glu Val Tyr Asp  Lys Ser Met 
    1250                 1255                 1260             


Leu Gly  Cys Ile Cys Arg Leu  Phe Lys Phe Asp Tyr  Asn Asp Leu 
    1265                 1270                 1275             


Tyr Gly  Ala Asn Arg Gln 
    1280                 


<210>  1142
<211>  1284
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1142

Met Ile Ile Gly Gly Ile Asn Met Lys Leu Thr Arg Arg Arg Ile Ser 
1               5                   10                  15      


Gln Glu Arg Lys Asn Gln Lys Leu Thr Ala Ala Phe Tyr Arg Asp Met 
            20                  25                  30          


Asp His Gly Leu Leu Tyr Val Asp Ser Glu Asp Glu Asp Arg Thr Glu 
        35                  40                  45              


Tyr Val Val Ser Ser Met Asp Phe Glu Arg Ser Trp Arg Gly Arg Ile 
    50                  55                  60                  


Leu Lys Asn Gly Glu Asp Asn Lys Asn Pro Phe Tyr Glu Phe Val Lys 
65                  70                  75                  80  


Gly Leu Val Gly Ser Asn Glu Ile Ile Cys Lys Pro Ile Thr Asn Asp 
                85                  90                  95      


Asn Asn Thr Asp Ile Asn Glu Lys Ile Lys Lys Tyr Ile Thr Glu Phe 
            100                 105                 110         


Gly Arg Asn Leu Lys Ala Pro Gly Ser Glu Val Thr Leu Glu Lys Leu 
        115                 120                 125             


Ile Leu Asn Ile Gln Ser Gly Thr Ser Glu Asn Glu Val Arg Pro Glu 
    130                 135                 140                 


Leu Glu Lys Ile Lys Asp Met Ile Lys Lys Asp Ile Glu Lys Arg Lys 
145                 150                 155                 160 


Asp Glu Leu Ile Lys Ser Ile Thr Asn Asn His Ile Pro Phe Met Leu 
                165                 170                 175     


Asp Glu Asp Lys Leu Val Pro Ser Thr Lys Lys Met Lys Trp Leu Tyr 
            180                 185                 190         


Lys Phe Leu Asn Gly Pro Asp Lys Ser Leu Asn Leu Gln Met Phe Asp 
        195                 200                 205             


Glu Tyr Trp Ile Lys Tyr Gly Tyr Lys Asn Leu Glu Glu Lys Ile Ile 
    210                 215                 220                 


Lys Glu Ile Asn Ser Leu Pro Glu Lys Asn Ala Arg Ser Ile Ser Arg 
225                 230                 235                 240 


Ala Val Ser Lys Thr Val Arg Glu Tyr Asn Arg Asn Phe Arg Ile Asn 
                245                 250                 255     


Tyr Met Val Pro Glu Asn Glu Asn Ala Glu Ala Asp Ser Asp Tyr Glu 
            260                 265                 270         


Gly Phe Leu Leu Phe Leu Lys Ala Val Glu Gln His Phe Lys Lys Tyr 
        275                 280                 285             


Tyr Pro Val Lys Ser Lys Asp Ser Ser Glu Val Arg Asp Lys Asn Leu 
    290                 295                 300                 


Cys Glu Glu Lys Asn Tyr Lys Phe Tyr Cys Ser Tyr Asn Phe Val Lys 
305                 310                 315                 320 


Asn Glu Val Lys Arg Ser Ile Ile Asn Gln Leu Val Ser Gly Leu Ile 
                325                 330                 335     


Gln Gln Gly Lys Leu Leu His Tyr Phe Tyr Lys Asp Gly Ile Trp Gln 
            340                 345                 350         


Gln Asp Phe Leu Asn Ser Tyr Gly Leu Ser Tyr Ile Gln Val Glu Glu 
        355                 360                 365             


Ser Phe Lys Lys Ser Leu Met Thr Ser Leu Ser Trp Gly Ile Asn Arg 
    370                 375                 380                 


Leu Thr Ser Phe Phe Ile Asp Val Gly Thr Asp Glu Asn Glu Glu Lys 
385                 390                 395                 400 


Thr Val Gln Asn Lys Lys Gln Lys Asn Asn Arg Lys Ile Asp Asp Ile 
                405                 410                 415     


Leu Ser Asp Lys Ser Asn Leu Arg Ala Ile Phe Asn Asp Leu Arg Ser 
            420                 425                 430         


Asn Thr Glu Leu Gln Lys His Phe Lys Glu Lys Leu Ala Phe Cys Tyr 
        435                 440                 445             


Pro Ile Phe Ile Lys Val Lys Lys Glu Lys Met Phe Asp Asp Ile Glu 
    450                 455                 460                 


Lys Leu Ile Lys Leu Val Glu Glu Ala Arg Glu Ser Val Ala Tyr Leu 
465                 470                 475                 480 


Arg His Arg Cys Phe His Tyr Lys Asp Val Thr Ile Thr Glu Met Leu 
                485                 490                 495     


Lys Ala Leu Asn Asn Asn Thr Glu Thr Asp Lys Thr Glu Asp Ile Asp 
            500                 505                 510         


Tyr Ser Val Ala Ala Glu Tyr Phe Leu Arg Asp Ile Asn Asn Leu Tyr 
        515                 520                 525             


Asp Ala Phe Arg Glu Gln Ile Arg Ser Ser Gly Ile Ala Asp Tyr Tyr 
    530                 535                 540                 


Pro Ala Asp Ile Ile Ser Gly Cys Phe Lys Lys Cys Gly Leu Gln Phe 
545                 550                 555                 560 


Val Leu Tyr Ser Pro Gln Asn Ser Leu Met Pro Ser Phe Lys Asn Ile 
                565                 570                 575     


Tyr Lys Arg Gly Ser Asn Leu Tyr Lys Ala Tyr Gln Glu Glu Lys Glu 
            580                 585                 590         


Gln Lys Asp Lys Glu Tyr Lys Arg His Asn Thr Asn Ile Val Gln Glu 
        595                 600                 605             


Glu Ser Lys Glu Leu Ser Trp Tyr Ile Glu Val Ser Asp Thr Glu Gln 
    610                 615                 620                 


Gly Lys Thr Ala Tyr Arg Asn Leu Leu Gln Leu Ile Tyr Tyr His Ala 
625                 630                 635                 640 


Phe Leu Pro Glu Val Arg Glu Asn Glu Ser Leu Ile Thr Val Tyr Phe 
                645                 650                 655     


Ala Lys Thr Lys Glu Trp Asn Arg Lys Val Ala Glu Thr Lys Ala Lys 
            660                 665                 670         


Lys Lys Asn Ala Gly Lys Thr Tyr Lys Asp Lys Pro Ile Arg Ala Tyr 
        675                 680                 685             


Arg Tyr Glu Ala Ile Pro Asp Tyr Val Gly Glu Arg Leu Asp Asp Tyr 
    690                 695                 700                 


Phe Lys Ile Leu Gln Arg Glu Gln Met Ala Lys Ala Lys Asp Val Asn 
705                 710                 715                 720 


Glu Gly Asn Ala Glu Asn Asn Asn Tyr Ile Gln Phe Ile Arg Asp Val 
                725                 730                 735     


Val Val Trp Ala Phe Gly Ala Tyr Leu Glu Glu Arg Leu Glu Lys Tyr 
            740                 745                 750         


Lys Lys Asp Leu Gln Ser Ser His Ser Gln Lys Asp Lys Lys Asp Val 
        755                 760                 765             


Asn Asp Ala Leu Lys Glu Leu Phe Pro Asp Asp Lys Asp Lys Arg Gln 
    770                 775                 780                 


Phe Phe Met Lys Cys Lys Phe Thr Asp Val Leu Ile Asn Asp Val Gly 
785                 790                 795                 800 


Glu Asn Asn Gln Ile Thr Glu Met Glu Asp Leu Glu Thr Ser Lys Glu 
                805                 810                 815     


Gln Gln Asn Arg Glu Ile Lys Arg Lys Asp Leu Leu Cys Phe Tyr Leu 
            820                 825                 830         


Phe Leu Arg Leu Leu Asp Glu Arg Glu Ile Ser Gly Leu Lys His Gln 
        835                 840                 845             


Phe Val Arg Tyr Arg Cys Ser Leu Lys Glu Arg Arg Leu Pro Asp Asn 
    850                 855                 860                 


Arg Lys Asp Val Asp Glu Glu Ile Val Leu Leu Glu Glu Leu Glu Glu 
865                 870                 875                 880 


Leu Met Glu Leu Val Ser Tyr Thr Met Pro Ser Val Pro Glu Leu Ser 
                885                 890                 895     


Gly Lys Ala Glu Ser Gly Leu Asp Leu Val Ile Ser Lys Tyr Phe Lys 
            900                 905                 910         


Asp Phe Phe Glu Lys Ser Ala Leu Lys Asn Gln Asp Ile Met Lys Leu 
        915                 920                 925             


Tyr Tyr Gln Ser Asp Asn Lys Thr Pro Val Phe Arg Lys Tyr Met Ala 
    930                 935                 940                 


Leu Leu Met Arg Ser Ala Pro Leu Gln Leu Tyr Lys Asp Met Phe Arg 
945                 950                 955                 960 


Asn Tyr Tyr Ile Ile Thr Glu Lys Glu Cys Gln Glu Tyr Ile Lys Thr 
                965                 970                 975     


Ser Gln Asp Ile Asp Ala Phe Gln Cys Lys Leu Asn Glu Leu His Lys 
            980                 985                 990         


Glu Leu Glu His Val Arg Leu Lys  Thr Val Glu Asp Lys  Lys Gly Lys 
        995                 1000                 1005             


Ile Phe  Tyr Tyr Leu Ala Gly  Ser Asp Ala Glu Arg  Val Lys Glu 
    1010                 1015                 1020             


Tyr Glu  Asp Thr Leu Ser Lys  Val Val Arg Tyr Lys  Arg Leu Gln 
    1025                 1030                 1035             


His Lys  Leu Thr Phe Glu Ser  Leu Tyr Thr Ile Phe  Lys Ile His 
    1040                 1045                 1050             


Val Asp  Ile Ala Ala Arg Met  Val Gly Tyr Thr Glu  Asp Trp Glu 
    1055                 1060                 1065             


Arg Asp  Met Leu Phe Leu Phe  Lys Ser Leu Glu Tyr  Asn Glu Lys 
    1070                 1075                 1080             


Leu Asn  Glu Gly Val Val Glu  Lys Ile Phe Asn Asn  Lys Asp Glu 
    1085                 1090                 1095             


Lys Gly  His Ile Val Lys Lys  Leu Lys Asp Asn Leu  Asn Ser Glu 
    1100                 1105                 1110             


Asp Lys  Glu Lys Ile Glu Ile  Leu Cys Trp His Lys  Glu Ile Thr 
    1115                 1120                 1125             


Asp Lys  Asn Phe Val Glu Ile  Ile Trp Ile Arg Asn  Pro Ile Ala 
    1130                 1135                 1140             


His Leu  Asn His Phe Met Gln  Thr Val Lys Asn Pro  Lys Arg Ser 
    1145                 1150                 1155             


Leu Glu  Lys Met Ile Asn Ala  Leu Cys Val Leu Leu  Ser Tyr Asp 
    1160                 1165                 1170             


Arg Lys  Arg Gln Asn Ser Val  Thr Lys Thr Ile Asn  Asp Leu Leu 
    1175                 1180                 1185             


Leu Asn  Glu Tyr His Val Lys  Ile Lys Trp Lys Arg  Trp Val Asp 
    1190                 1195                 1200             


Lys Asn  Cys Asn Ile Tyr Tyr  Tyr Ile Asp Glu Gln  Asn Ile Glu 
    1205                 1210                 1215             


Asn Glu  Pro Ile Leu His Ile  Lys His Leu His Met  Gly Glu Lys 
    1220                 1225                 1230             


Cys His  Val Asn Arg Asn Ala  Asp Met Phe Asp Arg  Gln Lys Glu 
    1235                 1240                 1245             


Trp Leu  Arg Asn Gly Ile Thr  Glu Glu Val Tyr Asp  Lys Ser Met 
    1250                 1255                 1260             


Leu Gly  Cys Ile Cys Arg Leu  Phe Lys Phe Asp Tyr  Asn Asp Leu 
    1265                 1270                 1275             


Tyr Gly  Ala Asn Arg Gln 
    1280                 


<210>  1143
<211>  1188
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1143

Met Lys Val Thr Lys Ile Asp Gly Leu Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Phe Arg Asn Asn Lys Asn Ile Asn Glu Ile 
            20                  25                  30          


Lys Glu Arg Leu Lys Lys Leu Lys Glu Leu Lys Leu Asp Asn Tyr Ile 
        35                  40                  45              


Lys Asn Pro Glu Asn Val Lys Asn Lys Asp Lys Asp Ala Glu Lys Glu 
    50                  55                  60                  


Thr Lys Ile Arg Arg Thr Asn Leu Lys Lys Tyr Phe Ser Glu Ile Ile 
65                  70                  75                  80  


Leu Arg Lys Glu Asp Glu Lys Tyr Ile Leu Lys Lys Thr Lys Lys Phe 
                85                  90                  95      


Lys Asp Ile Asn Gln Glu Ile Asp Tyr Tyr Asp Val Lys Ser Lys Lys 
            100                 105                 110         


Asn Gln Gln Glu Ile Phe Asp Val Leu Lys Glu Ile Leu Glu Leu Lys 
        115                 120                 125             


Ile Lys Glu Thr Glu Lys Glu Glu Ile Ile Thr Phe Asp Ser Glu Lys 
    130                 135                 140                 


Leu Lys Lys Val Phe Gly Glu Asp Phe Val Lys Lys Glu Ala Lys Ile 
145                 150                 155                 160 


Lys Ala Ile Glu Lys Ser Leu Lys Ile Asn Lys Ala Asn Tyr Lys Lys 
                165                 170                 175     


Asp Ser Ile Lys Ile Gly Asp Asp Lys Tyr Ser Asn Val Lys Gly Glu 
            180                 185                 190         


Asn Lys Arg Ser Arg Ile Tyr Glu Tyr Tyr Lys Lys Ser Glu Asn Leu 
        195                 200                 205             


Lys Lys Phe Glu Glu Asn Ile Arg Glu Ala Phe Glu Lys Leu Tyr Thr 
    210                 215                 220                 


Glu Glu Asn Ile Lys Glu Leu Tyr Ser Lys Ile Glu Glu Val Leu Lys 
225                 230                 235                 240 


Lys Thr His Leu Lys Ser Ile Val Arg Glu Phe Tyr Gln Asn Glu Ile 
                245                 250                 255     


Ile Gly Glu Ser Glu Phe Ser Glu Lys Gly Glu Asp Gly Ile Ser Ile 
            260                 265                 270         


Leu Tyr Asn Gln Ile Ile Arg Ser Asn Glu Lys Lys Glu Lys Phe Val 
        275                 280                 285             


Lys Phe Leu Glu Asn Ile Glu Asn Leu Gln Leu Lys Glu Leu Thr Lys 
    290                 295                 300                 


Ser Gln Ile Phe Tyr Lys Tyr Phe Leu Glu Asn Glu Glu Leu Asp Asp 
305                 310                 315                 320 


Glu Asn Ile Lys Asn Val Phe Cys Tyr Phe Val Glu Ile Glu Val Asn 
                325                 330                 335     


Asp Leu Leu Lys Gly Asn Val Tyr Arg Val Ser Lys Ile Tyr Glu Asn 
            340                 345                 350         


Lys Ile Lys Asn Ile Phe Glu Tyr Asn Lys Leu Lys Lys Leu Val Ile 
        355                 360                 365             


Asn Lys Leu Glu Asn Lys Leu Asn Asn Tyr Val Arg Asn Cys Gly Lys 
    370                 375                 380                 


Tyr Asn Tyr His Met Glu Asn Gly Asp Ile Ala Thr Ser Asp Ile Asn 
385                 390                 395                 400 


Met Arg Asn Arg Gln Lys Glu Ala Phe Leu Arg Ser Met Ile Gly Val 
                405                 410                 415     


Ser Ser Phe Gly Tyr Phe Ser Leu Arg Asn Ile Leu Gly Val Asn Asp 
            420                 425                 430         


Asp Asp Phe Tyr Glu Ile Glu Glu Asp Leu Thr Glu Asp Glu Arg Lys 
        435                 440                 445             


Lys Glu Ser Ser Thr Leu Lys Lys Val Lys Glu Asp Ile Ala Asn Lys 
    450                 455                 460                 


Ser Ile Phe Glu Lys Val Val Asp Lys Ser Phe Gln Lys Lys Gly Ile 
465                 470                 475                 480 


Tyr Asp Ile Lys Glu Asn Leu Lys Met Phe Tyr Gly Asp Ser Phe Asp 
                485                 490                 495     


Asp Ala Asp Glu Asp Glu Leu Lys Gln Phe Phe Val Asn Met Leu Asn 
            500                 505                 510         


Ala Ile Thr Ser Ile Arg His Arg Val Val His Tyr Asn Met Asn Thr 
        515                 520                 525             


Asn Ser Glu Asn Ile Phe Asn Phe Ser Asp Ile Glu Val Ser Arg Leu 
    530                 535                 540                 


Leu Lys Asn Ile Phe Glu Lys Glu Thr Asp Lys Arg Glu Leu Lys Leu 
545                 550                 555                 560 


Lys Ile Phe Arg Gln Leu Asn Ser Ala Gly Val Phe Asp Tyr Trp Glu 
                565                 570                 575     


Ser Trp Lys Ile Lys Lys Tyr Leu Glu Asn Ile Glu Phe Lys Phe Val 
            580                 585                 590         


Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys Leu Tyr Asn Arg 
        595                 600                 605             


Ile Asp Asn Leu Lys Gly Ser Asn Ala Leu Asn Leu Gly Tyr Ile Asn 
    610                 615                 620                 


Ile Pro Lys Arg Lys Glu Ala Arg Asp Ser Gln Ile Tyr Leu Leu Lys 
625                 630                 635                 640 


Asn Ile Tyr Tyr Gly Glu Phe Val Glu Glu Phe Val Asn Asn Asn Asp 
                645                 650                 655     


Asn Phe Glu Lys Ile Phe Arg Glu Ile Ile Glu Ile Asn Lys Asn Ala 
            660                 665                 670         


Gly Thr Asn Thr Lys Thr Lys Phe Tyr Lys Leu Glu Lys Phe Glu Thr 
        675                 680                 685             


Leu Lys Ala Asn Thr Pro Thr Glu Tyr Leu Glu Lys Leu Gln Ser Leu 
    690                 695                 700                 


His Gln Ile Asn Tyr Asp Arg Glu Lys Ile Glu Glu Asp Lys Asp Ile 
705                 710                 715                 720 


Tyr Val Asp Phe Val Gln Lys Ile Phe Leu Lys Gly Phe Ile Asn Tyr 
                725                 730                 735     


Leu Gln Glu Ser Gly Ser Leu Lys Tyr Leu Leu Asn Leu Glu Lys Ser 
            740                 745                 750         


Glu Val Ile Ala Asn Lys Lys Ser Ser Tyr Asp Glu Lys Leu Lys Leu 
        755                 760                 765             


Trp Gln Asn Asn Gly Ser Asn Leu Ser Lys Met Pro Glu Glu Ile Tyr 
    770                 775                 780                 


Glu Tyr Ile Lys Lys Ile Lys Ile Asn Lys Ile Asn Tyr Ser Asp Arg 
785                 790                 795                 800 


Met Ser Ile Phe Tyr Leu Leu Leu Lys Leu Ile Asp Tyr Arg Glu Leu 
                805                 810                 815     


Thr Asn Leu Arg Gly Asn Leu Glu Lys Tyr Glu Ser Met Asn Lys Asn 
            820                 825                 830         


Glu Ile Tyr Ser Glu Glu Leu Asn Ile Val Asn Leu Val Ser Leu Asp 
        835                 840                 845             


Asn Asn Lys Val Arg Ala Asn Phe Asn Leu Lys Pro Glu Asp Ile Gly 
    850                 855                 860                 


Lys Phe Leu Lys Thr Glu Thr Ser Ile Arg Asn Ile Asn Gln Leu Asn 
865                 870                 875                 880 


Asn Phe Ser Glu Ile Phe Ala Asp Gly Glu Asn Val Ile Lys His Arg 
                885                 890                 895     


Ser Phe Tyr Asn Ile Lys Lys Tyr Gly Ile Leu Asp Leu Leu Glu Lys 
            900                 905                 910         


Ile Val Asp Lys Ala Asp Leu Lys Ile Thr Lys Glu Glu Ile Lys Lys 
        915                 920                 925             


Tyr Glu Asn Leu Gln Asn Glu Leu Lys Arg Asn Asp Phe Tyr Lys Ile 
    930                 935                 940                 


Gln Glu Arg Ile His Lys Asn Tyr Asn Gln Lys Pro Phe Leu Ile Lys 
945                 950                 955                 960 


Asn Asn Glu Lys Asp Phe Asn Asp Tyr Lys Lys Ala Ile Glu Asn Ile 
                965                 970                 975     


Gln Asn Tyr Thr Gln Leu Lys Asn Lys Ile Glu Phe Asn Asp Leu Asn 
            980                 985                 990         


Leu Leu Gln Ser Leu Leu Phe Arg  Ile Leu His Arg Leu  Ala Gly Tyr 
        995                 1000                 1005             


Thr Ser  Leu Trp Glu Arg Asp  Leu Gln Phe Lys Leu  Lys Gly Glu 
    1010                 1015                 1020             


Tyr Pro  Glu Asp Lys Tyr Ile  Asp Glu Ile Phe Asn  Phe Asp Asn 
    1025                 1030                 1035             


Ser Lys  Asn Glu Lys Tyr Lys  Asn Gly Ala Ile Val  Phe Lys Tyr 
    1040                 1045                 1050             


Val Asp  Phe Leu Ile Glu Lys  Lys Glu Gly Lys Arg  Ala Arg Thr 
    1055                 1060                 1065             


Lys Lys  Ile Asn Lys Lys Ser  Glu Glu Lys Gly Leu  Glu Ile Arg 
    1070                 1075                 1080             


Asn Tyr  Ile Ala His Phe Asn  Tyr Ile Pro Asp Ala  Thr Lys Ser 
    1085                 1090                 1095             


Ile Leu  Glu Ile Leu Glu Glu  Leu Arg Asn Leu Leu  Lys Tyr Asp 
    1100                 1105                 1110             


Arg Lys  Leu Lys Asn Ala Val  Met Lys Ser Ile Lys  Asp Ile Phe 
    1115                 1120                 1125             


Lys Lys  Tyr Gly Phe Ile Ile  Glu Leu Lys Ile Pro  His Val Asn 
    1130                 1135                 1140             


Asn Ser  Glu Lys Ile Glu Val  Leu Asn Val Asp Ser  Glu Lys Ile 
    1145                 1150                 1155             


Lys His  Leu Lys Asn Asn Gly  Leu Val Thr Thr Arg  Asn Ser Glu 
    1160                 1165                 1170             


Asp Leu  Cys Glu Leu Ile Lys  Met Met Leu Glu Tyr  Lys Lys Ser 
    1175                 1180                 1185             


<210>  1144
<211>  1155
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1144

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Asn Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys His Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Asn Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Lys Ile Glu Met Ser Gln 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Lys Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Asn Phe Tyr Glu Lys Asp Val Ile Ile Lys Tyr Leu Lys Asn Thr Lys 
    530                 535                 540                 


Phe Asn Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Asn Lys Ile Glu Asp Leu Arg Asn Thr Leu Lys Phe Phe Trp 
                565                 570                 575     


Ser Val Pro Lys Asp Lys Glu Glu Lys Asp Ala Gln Ile Tyr Leu Leu 
            580                 585                 590         


Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn Tyr Phe Met Ser Asn Asn 
        595                 600                 605             


Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile Ile Glu Leu Asn Lys Asn 
    610                 615                 620                 


Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr Lys Leu Gln Lys Phe Glu 
625                 630                 635                 640 


Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr Leu Ala Asn Ile Gln Ser 
                645                 650                 655     


Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp Glu Glu Glu Lys Asp Thr 
            660                 665                 670         


His Ile Asp Phe Ile Gln Lys Ile Phe Leu Lys Gly Phe Met Thr Tyr 
        675                 680                 685             


Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile Tyr Ile Gly Ser Asp Glu 
    690                 695                 700                 


Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys Gln Glu Phe Asp Lys Phe 
705                 710                 715                 720 


Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile Lys Ile Pro Tyr Glu Ile 
                725                 730                 735     


Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly Asn Ile Leu Lys Tyr Thr 
            740                 745                 750         


Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu Lys Leu Leu Asn His Lys 
        755                 760                 765             


Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu Lys Tyr Gln Ser Ala Asn 
    770                 775                 780                 


Lys Glu Glu Thr Phe Ser Asp Gln Leu Glu Leu Ile Asn Leu Leu Asn 
785                 790                 795                 800 


Leu Asp Asn Asn Arg Val Thr Glu Asp Phe Glu Leu Glu Ala Asp Glu 
                805                 810                 815     


Ile Gly Lys Phe Leu Asn Phe Asn Gly Asn Lys Ile Lys Asp Arg Lys 
            820                 825                 830         


Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile Tyr Phe Asp Gly Glu Asn 
        835                 840                 845             


Ile Ile Lys His Arg Ala Phe Tyr Asn Ile Lys Lys Tyr Gly Met Leu 
    850                 855                 860                 


Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala Lys Tyr Lys Ile Ser Leu 
865                 870                 875                 880 


Lys Glu Leu Lys Glu Tyr Ser Asn Lys Lys Asn Glu Ile Glu Lys Asn 
                885                 890                 895     


Tyr Thr Met Gln Gln Asn Leu His Arg Lys Tyr Ala Arg Pro Lys Lys 
            900                 905                 910         


Asp Glu Lys Phe Asn Asp Glu Asp Tyr Lys Glu Tyr Glu Lys Ala Ile 
        915                 920                 925             


Gly Asn Ile Gln Lys Tyr Thr His Leu Lys Asn Lys Val Glu Phe Asn 
    930                 935                 940                 


Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu Lys Ile Leu His Arg Leu 
945                 950                 955                 960 


Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp Leu Arg Phe Arg Leu Lys 
                965                 970                 975     


Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu Glu Ile Phe Asn Phe Asp 
            980                 985                 990         


Asn Ser Lys Asn Val Lys Tyr Lys  Ser Gly Gln Ile Val  Glu Lys Tyr 
        995                 1000                 1005             


Ile Asn  Phe Tyr Lys Glu Leu  Tyr Lys Asp Asn Val  Glu Lys Arg 
    1010                 1015                 1020             


Ser Ile  Tyr Ser Asp Lys Lys  Val Lys Lys Leu Lys  Gln Glu Lys 
    1025                 1030                 1035             


Lys Asp  Leu Tyr Ile Arg Asn  Tyr Ile Ala His Phe  Asn Tyr Ile 
    1040                 1045                 1050             


Pro His  Ala Glu Ile Ser Leu  Leu Glu Val Leu Glu  Asn Leu Arg 
    1055                 1060                 1065             


Lys Leu  Leu Ser Tyr Asp Arg  Lys Leu Lys Asn Ala  Val Met Lys 
    1070                 1075                 1080             


Ser Val  Val Asp Ile Leu Lys  Glu Tyr Gly Phe Val  Ala Lys Phe 
    1085                 1090                 1095             


Lys Ile  Gly Ala Asp Lys Lys  Ile Gly Ile Gln Thr  Leu Glu Ser 
    1100                 1105                 1110             


Glu Lys  Ile Val His Leu Lys  Asn Leu Lys Lys Lys  Lys Leu Met 
    1115                 1120                 1125             


Thr Asp  Arg Asn Ser Glu Glu  Leu Cys Lys Leu Val  Lys Val Met 
    1130                 1135                 1140             


Phe Glu  Tyr Lys Met Glu Glu  Lys Lys Ser Glu Asn  
    1145                 1150                 1155 


<210>  1145
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1145

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Leu Tyr Gln Ile Val  Ser Ala Phe Asn Phe  Gly Ser Lys 
    1205                 1210                 1215             


Leu Leu  Tyr Ile Ser Glu Asp  Gly Arg Trp Lys Met  Ala Gly Gly 
    1220                 1225                 1230             


Ala Phe  Pro Gly Lys Tyr Gly  Arg Phe Glu Asn Asp  Tyr Asn His 
    1235                 1240                 1245             


Arg Thr  Ser Leu Ser Lys Val  Ile Arg Leu Phe Glu  Asn Glu Ser 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ile Ile Tyr  Trp Arg Asp Tyr Val  Asp His Met 
    1265                 1270                 1275             


Lys Tyr  Tyr Val Asn Gln Asn  Gln Ser Ile Met Glu  Ile Tyr Ser 
    1280                 1285                 1290             


Ala Phe  Tyr Ser Lys Val Leu  Gly Tyr Ser Ala Lys  Leu Arg Lys 
    1295                 1300                 1305             


Ser Val  Val Phe Asn Leu Gln  Ala Ala Leu Glu Lys  His His Ile 
    1310                 1315                 1320             


Asn Pro  Glu Cys Ile Trp Met  Thr Ser Asp Gly Lys  Cys Ala Asp 
    1325                 1330                 1335             


Ile Lys  Leu Met Lys Asn Leu  Glu Ser Gln Lys Phe  Thr Tyr Lys 
    1340                 1345                 1350             


Leu Ala  Lys Arg Glu Gly Glu  Lys Thr Glu Arg Lys  Ile Cys Met 
    1355                 1360                 1365             


Asn Ala  Leu Asn Glu Asn Phe  Leu Lys Thr Ile Arg  Thr Ser Leu 
    1370                 1375                 1380             


Glu Tyr  Lys Lys 
    1385         


<210>  1146
<211>  1247
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1146

Met Lys Ile Thr Lys Arg Lys Trp Gly Glu His His Pro Pro Leu Tyr 
1               5                   10                  15      


Phe Tyr Arg Asp Glu Asp Ser Gly Arg Leu Leu Ala Gln Asn Asp Arg 
            20                  25                  30          


Lys Gln Asp Tyr Thr Asp Thr Leu Phe Asn Asp Ile Ala Gln Asp Thr 
        35                  40                  45              


Phe Glu Arg Ser Leu Arg Asn Arg Leu Leu Lys Thr Pro Glu Lys Gly 
    50                  55                  60                  


Asp Lys Arg Phe Tyr Ser Asn Glu Ile Val Lys Leu Val Glu Lys Leu 
65                  70                  75                  80  


Cys Gln Gly Ala Asp Val Ala Glu Ile Met Lys Ser Met Glu Arg Ser 
                85                  90                  95      


Glu Lys Leu Arg Pro Lys Asn Glu Lys Glu Ile Lys Asn Leu Lys Lys 
            100                 105                 110         


Gln Leu Asp Gly Thr Leu Ser Glu Tyr Gly Lys Arg Tyr Thr Ala Pro 
        115                 120                 125             


Glu Gly Ala Met Thr Leu Asn Asp Ala Leu Phe Tyr Leu Val Glu Gly 
    130                 135                 140                 


Asn Pro Leu Lys Gln Ala Met Ala Lys Ala Glu Leu Gly Lys Ile Arg 
145                 150                 155                 160 


Glu Ala Leu Ile Lys Glu Lys Glu Asn Arg Ile Asn Arg Val Arg Tyr 
                165                 170                 175     


Ser Ile Lys Asn Asn Lys Ile Pro Leu Arg Ile Gln Glu Asp Gly Gly 
            180                 185                 190         


Ile Thr Pro Asn Asn Asp Arg Ala Ala Trp Leu Leu Gly Leu Met Lys 
        195                 200                 205             


Pro Ala Asp Pro Ala Lys Gly Ile Thr Asp Cys Tyr Pro Leu Leu Gly 
    210                 215                 220                 


Glu Leu Glu Glu Val Phe Asp Phe Asp Lys Leu Ser Lys Thr Leu His 
225                 230                 235                 240 


Glu Lys Ile Ser Arg Cys Gln Gly Arg Pro Arg Ser Ile Ala Met Ala 
                245                 250                 255     


Val Asp Glu Ala Leu Lys Gln Tyr Leu Arg Glu Leu Trp Glu Lys Ser 
            260                 265                 270         


Pro Ser Arg Gln Gln Asp Leu Lys Tyr Tyr Phe Gln Ala Val Gln Glu 
        275                 280                 285             


Tyr Phe Lys Asp Asn Phe Pro Ile Arg Thr Lys Arg Met Gly Ala Arg 
    290                 295                 300                 


Leu Arg Gln Glu Leu Leu Lys Asp Lys Thr Ser Leu Ser Arg Leu Leu 
305                 310                 315                 320 


Glu Pro Lys His Met Ala Asn Ala Val Arg Arg Arg Leu Ile Asn Gln 
                325                 330                 335     


Ser Thr Gln Met His Ile Leu Tyr Gly Lys Leu Tyr Ala Tyr Cys Cys 
            340                 345                 350         


Gly Glu Asp Gly Arg Leu Leu Val Asn Ser Glu Thr Leu Gln Arg Ile 
        355                 360                 365             


Gln Val His Glu Ala Val Lys Lys Gln Ala Met Thr Ala Val Leu Trp 
    370                 375                 380                 


Ser Ile Ser Arg Leu Arg Tyr Phe Tyr Gln Phe Glu Asp Gly Asp Ile 
385                 390                 395                 400 


Leu Ser Asn Lys Asn Pro Ile Lys Asp Phe Arg Asp Lys Phe Leu Arg 
                405                 410                 415     


Asp Thr Asn Lys Tyr Thr His Glu Asp Val Glu Ala Cys Lys Glu Lys 
            420                 425                 430         


Leu Gln Asp Phe Phe Pro Leu Lys Glu Leu Gln Glu Lys Ile Lys Glu 
        435                 440                 445             


Asp Ala Lys Gly Leu Gln Glu Thr Asp Asn Lys Gln Ala Asp Thr Thr 
    450                 455                 460                 


Asp Phe Lys Ala Ile Gly His Ile Val Arg Asp Asp Arg Lys Leu Cys 
465                 470                 475                 480 


Asn Gln Leu Leu Ala Glu Cys Val Ser Cys Ile Gly Glu Leu Arg His 
                485                 490                 495     


His Ile Phe His Tyr Lys Asn Val Thr Leu Ile Gln Ala Leu Lys Arg 
            500                 505                 510         


Ile Ala Asp Lys Val Lys Pro Glu Glu Leu Ser Val Leu Arg Ala Ile 
        515                 520                 525             


Tyr Leu Leu Asp Arg Arg Asn Leu Lys Lys Ala Phe Ala Lys Arg Ile 
    530                 535                 540                 


Ser Ser Met Asn Leu Pro Leu Tyr Tyr Arg Glu Asp Leu Leu Ser Arg 
545                 550                 555                 560 


Ile Phe Lys Lys Glu Gly Thr Ala Phe Phe Leu Tyr Ser Ala Lys Ile 
                565                 570                 575     


Gln Met Thr Pro Ser Phe Gln Arg Val Tyr Glu Arg Gly Lys Asn Leu 
            580                 585                 590         


Arg Arg Glu Phe Glu Cys Glu Arg Met Lys Ala Glu Ala Ser Asn Gly 
        595                 600                 605             


Gln Asn Gly Gln Asp Gly Asp Arg Leu Lys Trp Phe Arg Gln Leu Ala 
    610                 615                 620                 


Ala Gly Asp Ser Ala Asp Thr His Phe Asn Trp Ala Val Glu Ala Tyr 
625                 630                 635                 640 


Ala Glu Ser Ala Ala Asp Val Glu Asn Asn Val Glu Phe Asp Thr Asp 
                645                 650                 655     


Val Asp Ala Gln Arg Ala Leu Arg Asn Leu Leu Leu Leu Ile Tyr Arg 
            660                 665                 670         


His His Phe Leu Pro Glu Val Gln Lys Asp Glu Thr Leu Val Thr Gly 
        675                 680                 685             


Lys Ile His Lys Val Leu Glu Arg Asn Arg Gln Leu Ser Glu Gly Gln 
    690                 695                 700                 


Gly Pro Asn Gln Gly Lys Ala His Gly Tyr Ser Val Ile Glu Glu Leu 
705                 710                 715                 720 


Tyr His Glu Gly Met Pro Leu Ser Asp Leu Met Lys Gln Leu Gln Arg 
                725                 730                 735     


Arg Ile Ser Glu Thr Glu Arg Glu Ser Arg Glu Leu Ala Gln Glu Lys 
            740                 745                 750         


Thr Asp Tyr Ala Gln Arg Phe Ile Leu Asp Ile Phe Ala Glu Ala Phe 
        755                 760                 765             


Asn Asp Phe Leu Glu Ala His Tyr Gly Glu Glu Tyr Leu Glu Ile Met 
    770                 775                 780                 


Ser Pro Arg Lys Asp Ala Glu Ala Ala Lys Lys Trp Val Lys Glu Ser 
785                 790                 795                 800 


Lys Thr Val Asp Leu Lys Thr Ser Ile Asp Glu Lys Glu Pro Glu Gly 
                805                 810                 815     


His Leu Leu Val Leu Tyr Pro Val Leu Arg Leu Leu Asp Glu Arg Glu 
            820                 825                 830         


Leu Gly Glu Leu Gln Gln Gln Met Ile Arg Tyr Arg Thr Ser Leu Ala 
        835                 840                 845             


Ser Trp Gln Gly Glu Ser Asn Phe Ser Glu Glu Ile Arg Ile Ala Gly 
    850                 855                 860                 


Gln Ile Glu Glu Leu Thr Glu Leu Val Lys Leu Thr Glu Pro Glu Pro 
865                 870                 875                 880 


Gln Phe Ala Glu Glu Val Trp Gly Lys Arg Ala Lys Glu Ala Phe Glu 
                885                 890                 895     


Asp Phe Ile Glu Gly Asn Met Lys Asn Tyr Glu Ala Phe Tyr Leu Gln 
            900                 905                 910         


Ser Asp Asn Asn Thr Pro Val Tyr Arg Arg Asn Met Ser Arg Leu Leu 
        915                 920                 925             


Arg Ser Gly Leu Met Gly Val Tyr Gln Lys Val Leu Ala Ser His Lys 
    930                 935                 940                 


Gln Ala Leu Lys Arg Asp Tyr Leu Leu Trp Ser Glu Lys His Trp Asn 
945                 950                 955                 960 


Val Lys Asp Glu Asn Gly Val Asp Ile Ser Ser Ala Glu Gln Ala Gln 
                965                 970                 975     


Cys Leu Leu Gln Arg Leu His Arg Lys Tyr Ala Glu Ser Pro Ser Arg 
            980                 985                 990         


Phe Thr Glu Glu Asp Cys Lys Leu  Tyr Glu Lys Val Leu  Arg Arg Leu 
        995                 1000                 1005             


Glu Asp  Tyr Asn Gln Ala Val  Lys Asn Leu Ser Phe  Ser Ser Leu 
    1010                 1015                 1020             


Tyr Glu  Ile Cys Val Leu Asn  Leu Glu Ile Leu Ser  Arg Trp Val 
    1025                 1030                 1035             


Gly Phe  Val Gln Asp Trp Glu  Arg Asp Met Tyr Phe  Leu Leu Leu 
    1040                 1045                 1050             


Ala Trp  Val Arg Gln Gly Lys  Leu Asp Gly Ile Lys  Glu Lys Asp 
    1055                 1060                 1065             


Val Ser  Gly Ile Phe Tyr Lys  Gly Ser Ile Ile Cys  Lys Leu Phe 
    1070                 1075                 1080             


Asn Thr  Leu Glu Gly Gly Asn  Trp Ala Ala Phe Ala  Ser Ile Tyr 
    1085                 1090                 1095             


Cys Pro  Gly Ser Lys Arg Thr  Lys Phe Leu Lys Val  Asn Asn Asp 
    1100                 1105                 1110             


Val His  Ala Thr Ala Pro Leu  Ser His Glu Lys Cys  Gln Tyr Glu 
    1115                 1120                 1125             


Phe Leu  Val Ala Arg Asn Met  Ile Ala His Leu Asp  Leu Met Arg 
    1130                 1135                 1140             


Lys Asn  Gly Trp Arg Leu Glu  Ala Gly Lys Thr Cys  Ser Val Met 
    1145                 1150                 1155             


Glu Asp  Tyr Ile Asn Arg Leu  Arg Phe Leu Leu Ser  Tyr Asp Gln 
    1160                 1165                 1170             


Lys Arg  Met Asn Ala Val Thr  Lys Thr Leu Gln Gln  Ile Phe Asp 
    1175                 1180                 1185             


Arg His  Lys Val Lys Ile Arg  Phe Thr Val Glu Lys  Gly Gly Met 
    1190                 1195                 1200             


Leu Lys  Ile Glu Asp Val Thr  Ala Asp Lys Ile Ala  His Leu Lys 
    1205                 1210                 1215             


Gly Ser  Arg Leu Ser Gly Ile  Glu Ile Pro Ser His  Gly Glu Arg 
    1220                 1225                 1230             


Phe Ile  Asp Thr Leu Lys Ala  Leu Met Val Tyr Pro  Arg Gly 
    1235                 1240                 1245         


<210>  1147
<211>  1287
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1147

Met Arg Ile Gly Lys Val Gln Gly Arg Thr Phe Thr Gly Phe Asp Asn 
1               5                   10                  15      


Ala Arg Gly Lys Thr Leu Arg Arg Arg Leu Leu Thr Arg Pro Asp Asn 
            20                  25                  30          


Glu Ala Arg Ser Leu Ser Glu His Leu Ala His Asp Pro Lys Ala Leu 
        35                  40                  45              


Ile Gly Gln Ala Ile Ser Arg Ile Asp Thr Ile Tyr Gln Lys Pro Lys 
    50                  55                  60                  


Thr Gly Lys Pro Thr Pro Glu Gln Phe Gly His Arg Asp Thr Leu Gly 
65                  70                  75                  80  


Trp Ala Tyr Trp Lys Leu Leu Val Ala Ser Tyr Pro Glu Val Glu Gly 
                85                  90                  95      


His Arg Asp Leu Phe Val Arg Arg Leu His Pro Tyr Gly Asp Thr Pro 
            100                 105                 110         


Pro Lys Ser His Gly Gln Lys Glu Gly Glu His Gln Lys Gly Gly Lys 
        115                 120                 125             


Pro Gln Leu Glu Gly Arg Trp His Gly Val Met Ala Gln His Gly Lys 
    130                 135                 140                 


Asn Pro Asp Gln Ile Ala Ala Arg Leu Phe Asp His Leu His Asn Ser 
145                 150                 155                 160 


Glu Leu Arg Phe Gly Gly Thr Ala Ser Gly Glu Pro Arg Thr Arg Pro 
                165                 170                 175     


Gly Lys Glu Ala Thr Pro Thr Gly Leu Ile Gly Ala Arg Ala Lys Thr 
            180                 185                 190         


Ile Glu His Ser Val Leu Pro Arg Asp Ala Lys Arg Phe Val Ala Glu 
        195                 200                 205             


Trp Arg Gly Glu Asp Gln Glu Arg Tyr Ala Gly Ala Arg Asp Ile Ala 
    210                 215                 220                 


Ala Ala Ile Ser Ala Gly Leu Asn Asp Lys Asp Gln Lys Ser Gly Ser 
225                 230                 235                 240 


Gly Arg Lys Ser Ala Val Ile Gly Lys Leu Leu Ser Asp His Leu Glu 
                245                 250                 255     


Thr Leu Thr Gly Asn Arg Lys Cys Arg Phe Asp Pro Lys Ser Thr Ala 
            260                 265                 270         


Glu Thr Leu Glu Leu Arg Asp Gly Glu Ser Val Asp Asp Arg Arg Arg 
        275                 280                 285             


Ile Leu Glu Leu His Ala Glu Val Lys Ala Thr Tyr Lys Arg Met Ala 
    290                 295                 300                 


Ala Trp Lys Pro Ala Lys Leu Pro Arg Asn Ser Asp Glu Leu Phe Arg 
305                 310                 315                 320 


Leu Val Arg Gln Gln Ala Asp Asn Arg Ile Leu Asn His Leu Val Arg 
                325                 330                 335     


Val Gly Arg Ile Ser Val Tyr Ser Glu Gln Ser Asp Ala Leu Ser Glu 
            340                 345                 350         


Ser Gln Phe Trp Thr Ser Gly Gly Gln Thr Gln Ile Lys Glu Ser Glu 
        355                 360                 365             


Val Phe Ala Arg Leu Trp Ile Gly Ala Ile Ser Arg Ala Ser Tyr Ser 
    370                 375                 380                 


Met Lys Ala Trp Leu Glu Pro Glu Gly Thr Val Phe Asn Pro Ser Ile 
385                 390                 395                 400 


Asn Asp Phe Asp Val Thr Ser Ser His Asn Thr Asn Arg Ile Leu Glu 
                405                 410                 415     


Asp Ser Gly Arg Leu Ser Asn Ala Met Ala Arg Arg Ala Ile Tyr Phe 
            420                 425                 430         


Gly Glu Thr Pro Glu Phe Asp Ala Leu Gly Glu Glu Asp Gln Arg Val 
        435                 440                 445             


Leu Val Lys Lys Cys Leu Asp Ala Leu Ser Ala Cys Arg Asn Arg Thr 
    450                 455                 460                 


Phe His His Gly Gln Arg Ala Lys Phe Leu Lys Glu Val Arg Lys Gly 
465                 470                 475                 480 


Leu Lys Glu Lys Glu Ala Asp Ser Ala Gly Pro Ala Ala Trp Glu Gly 
                485                 490                 495     


Ile Arg Glu Val Ile Gln Ala Asp Ala Arg Asn Leu Gly Ala Arg Leu 
            500                 505                 510         


Leu Gln Asp Leu Thr Gly Ala Lys Val His Ser Phe Ala Thr Asp Pro 
        515                 520                 525             


Glu Phe Arg His Leu Tyr Glu Ser Val Ala Ala Thr Leu Thr Ala Gly 
    530                 535                 540                 


Gly Glu Leu Glu Ala Ala Leu Pro Arg Leu Lys Asn Val Leu Lys Arg 
545                 550                 555                 560 


Ala Glu Gly Val Arg Cys Tyr Leu Asp Thr Pro Ser Gln Arg Arg Glu 
                565                 570                 575     


Gly Asp Glu Ser Leu Ile Ala Arg Leu Pro Val Ala Pro Val Pro Arg 
            580                 585                 590         


Glu Leu Asp Asp Ala Ala Thr Lys Ala Arg His Ser Ala Leu Leu Arg 
        595                 600                 605             


Leu Tyr Asp Gly Pro Phe Arg Pro Trp Ala Thr Glu Leu Arg Gly Glu 
    610                 615                 620                 


Arg Leu Ser Asp Tyr Ala Ala Arg Ala Lys Arg Leu Ala Thr Arg Leu 
625                 630                 635                 640 


Ala Lys Ser Thr Asn Thr Ala Ser Pro Tyr Pro Asp Ser Val Glu Gly 
                645                 650                 655     


Arg Ser Val Arg Leu Arg Asp Pro Ile Thr Ala Asp Thr Ala Pro Glu 
            660                 665                 670         


Thr Leu Lys Thr Tyr Leu Ser Ala Leu Thr Ala Glu Thr Ala Thr Glu 
        675                 680                 685             


Phe Arg Val Gln Lys Gly Tyr Glu Ser Asp Gly Glu Lys Ala Lys Glu 
    690                 695                 700                 


Gln Ala Glu Phe Ile Glu Asp Phe Arg Arg Asp Met Ile Ala Leu Ala 
705                 710                 715                 720 


Phe Gln Asp Phe Ile Arg Asp His Gly Phe Ala Trp Leu Leu Asp Ile 
                725                 730                 735     


Ala Ser Lys Ala Glu Pro Ser Asn Asp Ala Pro Asn Leu Pro Asp Pro 
            740                 745                 750         


Val Asp Thr Gly Lys Asp Thr Val Phe Glu Asp Trp Gln Ala Leu Leu 
        755                 760                 765             


Tyr Leu Phe Leu His Phe Val Pro Ala Asp Asp Val Ser Gln Leu Leu 
    770                 775                 780                 


His Gln Leu Arg Lys Trp Asp Ala Leu Gln Asp Lys Tyr Glu Leu Ala 
785                 790                 795                 800 


Glu Pro Gly Glu Thr Leu Gly Gln Thr Lys Ala Asp Thr Arg Lys Ile 
                805                 810                 815     


Val Gly Gln Phe Arg Asp Cys Leu Thr Leu Phe Leu Lys Thr Gly Asp 
            820                 825                 830         


Ala Arg Phe Asp Gly Glu Gly Val Glu Leu Pro Leu Ser Asp Phe Gln 
        835                 840                 845             


Glu Leu Phe Glu Ser Pro Ala Thr Phe Lys Glu Leu Phe Leu Ala Glu 
    850                 855                 860                 


Pro Ala Glu Asn Asp Ala Ser Glu Thr Asp Asp Gln Asp Ala Pro Gly 
865                 870                 875                 880 


Glu Lys His Arg Val Thr Arg Thr Arg Arg Gly Leu Arg Gln Ile Leu 
                885                 890                 895     


Arg Tyr Asn His Met Pro Val Leu Arg Asp Leu Phe Leu Ala His Lys 
            900                 905                 910         


Val Thr Asp Ala Glu Val Asp Gly Leu Gln Ala Leu Glu Val Asp Asp 
        915                 920                 925             


Pro Gln Thr Gly Glu Ser Gln Ile Gly Ala Ala Gln Arg Ile Arg Thr 
    930                 935                 940                 


Glu Ile His His His Thr Ser Asn Asp Lys Gln Ile Ser Glu Ala Lys 
945                 950                 955                 960 


Val Glu Glu Tyr Arg Arg Ala Leu Ser Thr Ile Glu Arg His Arg Phe 
                965                 970                 975     


Leu Val Gly Arg Val Tyr Leu Gly Asp His Ile Arg Val His Lys Leu 
            980                 985                 990         


Met Met Asp Val Met Gly Arg Leu  Val Asp Phe Ala Gly  Ala Trp Glu 
        995                 1000                 1005             


Arg Glu  Ala Ala Asp Gly Asp  Arg Lys Gly Phe Ile  Ser Arg Ala 
    1010                 1015                 1020             


Ile Ala  Leu Pro Glu Val Ala  Glu Gly Tyr Ala Ala  Asp Arg Leu 
    1025                 1030                 1035             


Lys Thr  Val Ala Arg Arg Val  Leu Asp Asp Gly Glu  Ala Arg Arg 
    1040                 1045                 1050             


Ile Arg  Asn Asp Leu Gly His  Phe Asn Asp Leu Ala  Pro Thr Ser 
    1055                 1060                 1065             


Gly Pro  Ala Asn Leu Thr Phe  Val Val Asn Arg Ala  Arg Arg Met 
    1070                 1075                 1080             


Met Arg  His Asp Arg Lys Arg  Lys Asn Ala Val Thr  Lys Ser Val 
    1085                 1090                 1095             


Ile Glu  Ile Leu Asn Arg Gln  Gly Leu Gly Ile Glu  Trp Thr Met 
    1100                 1105                 1110             


Arg Asn  His Glu Leu Cys Glu  Ala Lys Leu Trp Gln  Asn Pro Val 
    1115                 1120                 1125             


Lys His  Leu Gly Phe Ala Thr  Leu Glu Gly Arg Gly  Lys Lys Trp 
    1130                 1135                 1140             


Arg Arg  Pro Phe Glu Ala Arg  Tyr Gly Asp Ala Tyr  Met Ala Met 
    1145                 1150                 1155             


Val Ala  Gln Leu Phe Asp Gly  Thr Val Thr Ser Pro  Pro Ala Lys 
    1160                 1165                 1170             


Gly Pro  Pro Gln Ser Gly Lys  Ser Gly Gly Lys Pro  Gly Lys Gly 
    1175                 1180                 1185             


Ala Glu  Gly Gly Ala Lys Glu  Lys Ser Arg Ser Pro  Thr Arg Met 
    1190                 1195                 1200             


Glu Glu  Gly Gly Val Tyr Glu  Gly Arg Val Ala Lys  Ala Lys Ser 
    1205                 1210                 1215             


Asp Lys  Gly Phe Gly Phe Leu  Leu Val Glu Gly Ala  Gln Glu Glu 
    1220                 1225                 1230             


Ile Phe  Leu His Ile Tyr Gly  Ile Ser Gly Asn Arg  Pro Ala Arg 
    1235                 1240                 1245             


Ile Glu  Asn Gly Gln Arg Tyr  Arg Phe Thr Leu Gly  Ile Asp Arg 
    1250                 1255                 1260             


Asp Arg  Glu Arg Arg Lys Glu  Arg Ala Trp Val Ala  Arg Glu Ala 
    1265                 1270                 1275             


Val Arg  Ile Asp Glu Asn Arg  Ser Lys 
    1280                 1285         


<210>  1148
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1148

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Ile Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Asp Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Tyr Leu Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Lys Asn Tyr Lys Trp Arg Glu Ser Cys 
                85                  90                  95      


Ser Glu Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Thr 
        115                 120                 125             


Lys Asp Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Glu Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Gly Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Glu Thr Gly Leu Leu Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Thr Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Ile Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Lys Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  1149
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1149

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Pro 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Leu Tyr Gln Ile Val  Ser Ala Phe Asn Phe  Gly Ser Lys 
    1205                 1210                 1215             


Leu Leu  Tyr Ile Ser Glu Asp  Gly Arg Trp Lys Met  Ala Gly Gly 
    1220                 1225                 1230             


Ala Phe  Pro Gly Lys Tyr Gly  Arg Phe Glu Asn Asp  Tyr Asn His 
    1235                 1240                 1245             


Arg Thr  Ser Leu Ser Lys Val  Ile Arg Leu Phe Glu  Asn Glu Ser 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ile Ile Tyr  Trp Arg Asp Tyr Val  Asp His Met 
    1265                 1270                 1275             


Lys Tyr  Tyr Val Asn Gln Asn  Gln Ser Ile Met Glu  Ile Tyr Ser 
    1280                 1285                 1290             


Ala Phe  Tyr Ser Lys Val Leu  Gly Tyr Ser Ala Lys  Leu Arg Lys 
    1295                 1300                 1305             


Ser Val  Val Phe Asn Leu Gln  Ala Ala Leu Glu Lys  His His Ile 
    1310                 1315                 1320             


Asn Pro  Glu Cys Ile Trp Met  Thr Ser Asp Gly Lys  Cys Ala Asp 
    1325                 1330                 1335             


Ile Lys  Leu Met Lys Asn Leu  Glu Ser Gln Lys Phe  Thr Tyr Lys 
    1340                 1345                 1350             


Leu Ala  Lys Arg Glu Gly Glu  Lys Thr Glu Arg Lys  Ile Cys Met 
    1355                 1360                 1365             


Asn Ala  Leu Asn Glu Asn Phe  Leu Lys Thr Ile Arg  Thr Ser Leu 
    1370                 1375                 1380             


Glu Tyr  Lys Lys 
    1385         


<210>  1150
<211>  1211
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1150

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Ile Val  Ser Asp Ser Gln Cys  Phe 
    1205                 1210     


<210>  1151
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1151

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Asn Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys His Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Asn Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Glu 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Val Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Thr Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Lys Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Glu  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  1152
<211>  1330
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1152

Met Lys Arg Glu Lys Asn Ile Thr Ile Met Lys Ile Ser Lys Val Asn 
1               5                   10                  15      


His Arg Arg Met Ala Val Ala Leu Asn Gly Asp Lys Ser Glu Leu Gly 
            20                  25                  30          


Gly Ile Leu Tyr Glu Ala Pro Val Gln Lys Asp Lys Asn Gly Asn Tyr 
        35                  40                  45              


Asn Asp Val Ile Ala Glu Thr Gly Lys Val Val Asn Glu Ala Leu Asp 
    50                  55                  60                  


Lys Lys Ser Arg Leu Tyr Thr Pro Phe Asn Asn Gln Lys Val Ile Ile 
65                  70                  75                  80  


Asp Lys Asn Leu Gln Arg Tyr Ala Asn Asn Leu Lys Arg Cys Tyr Ile 
                85                  90                  95      


Asn Phe Val Lys Gln Tyr Val Asn Asn Lys Ser Phe Asn Tyr Lys Ala 
            100                 105                 110         


Met Gln Phe Ile Pro Asp Ile Gln Asn Pro Lys Thr Asn Asp Ala Val 
        115                 120                 125             


Asn Tyr Arg Thr Asp Arg Asp Asn Val Tyr Asn Lys Asn Lys Tyr Tyr 
    130                 135                 140                 


Asp Lys Gln Thr Lys Ser Lys Ser Lys Lys Phe Ile Tyr Glu Lys Ile 
145                 150                 155                 160 


Val Ile Pro Gln Asn Glu Gln Asn Ile Val Ile Ser Ala Leu Val Asn 
                165                 170                 175     


Cys Ser Leu Arg Lys Ser Leu Arg Lys Asp Val Ser Tyr Lys Thr Lys 
            180                 185                 190         


Ser Gly Glu Ile Lys Thr Tyr Asn Leu Pro Glu Leu Val Lys Lys Ser 
        195                 200                 205             


Met Arg Phe Tyr Cys Leu Glu Gly Gln Arg Glu Pro Asp Glu Lys Glu 
    210                 215                 220                 


Lys Tyr Glu Met Tyr Ile Leu Phe Ser Tyr Met Lys Glu Asp Lys Arg 
225                 230                 235                 240 


Thr Lys Asn Thr Asp Leu Leu Val Lys Ser Ile Ser Asn Gln Asn Thr 
                245                 250                 255     


Lys Val Lys Val Glu Asp Ile Asp Gly Asn Lys Leu Leu Lys Leu Ser 
            260                 265                 270         


Ile Ala Asp Thr Lys Lys Glu Pro Leu Trp Glu Tyr Leu Ile Lys Tyr 
        275                 280                 285             


Ala Asp Ser Ser Arg Gln Arg Glu Leu Met Tyr Asp Ile Arg Lys Lys 
    290                 295                 300                 


Ile Val Leu Tyr Val Ala Gly Ile Glu Glu Tyr Glu Asn Ile Lys Glu 
305                 310                 315                 320 


Asp Ser Gly Leu Ser Lys Val Ser Trp Ser Lys Tyr Asn Ile Ser Asp 
                325                 330                 335     


Asn Lys Met Phe Phe Asp Ile Asn Ser Cys Thr Asp Lys Arg Lys Gln 
            340                 345                 350         


Asn Leu Glu Ile Lys Ile Arg Glu Ala Asn Ile Glu His Tyr Arg Asn 
        355                 360                 365             


Ala Ser Ser Lys Leu Cys Asp Asp Glu Ser Ile Phe Trp Phe Gln His 
    370                 375                 380                 


Phe Glu Gly Val Ile Glu Thr Leu Phe Ser Lys Lys Ser Lys Ile Ser 
385                 390                 395                 400 


Glu Glu Arg Leu Gly Cys Ala Tyr Ile Cys Asp Tyr Leu Trp Lys Asp 
                405                 410                 415     


Phe Leu Ser Tyr Leu Ala Ala Lys Tyr Ile Asp Leu Gly Lys Gly Val 
            420                 425                 430         


Tyr His Phe Thr Met Lys Asp Lys Leu Asp Met Leu Asn Lys Asn Glu 
        435                 440                 445             


Ala Val Thr Asp Leu Arg Phe Gly Ile Val Ser Glu Lys Tyr Glu Lys 
    450                 455                 460                 


Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Glu Leu 
465                 470                 475                 480 


Asp Arg Asn Ile Ala Ala Tyr Val Thr Phe Ala Ala Asp Ile Phe Ala 
                485                 490                 495     


Lys Ser Val Ile Lys Ser Asp Tyr Arg Thr Lys Lys Asp Asn Asn Ser 
            500                 505                 510         


Asp Val Leu Gln Tyr Ser Asp Lys Glu Phe Arg Asn Ser Glu Val Ile 
        515                 520                 525             


Arg Asp Asn Ala Glu Lys Asn Ile Leu Gln Tyr Trp Gly Gly Tyr Ser 
    530                 535                 540                 


Arg Trp Gly Thr Glu Asn Ser Lys Leu Pro Glu Asn Asn Lys Val Ser 
545                 550                 555                 560 


Asp Phe Gly Lys Leu Asp Val Ser Asp Leu Cys Ile Asp Ile Lys Lys 
                565                 570                 575     


His Leu Ala Gly Ile Arg Asn Ser Ser Val His Tyr Thr Thr Lys Ile 
            580                 585                 590         


Lys Asn Glu Ser Ala Ala Asp Gly Ser Asn Val Lys Ile Leu Phe Glu 
        595                 600                 605             


Lys Asp Leu Ala Asp Ile Asn Ile Ile Tyr Ala Asp Lys Tyr Tyr Ser 
    610                 615                 620                 


Asn Asn Val Trp Met Phe Tyr Ser Leu Glu Asp Ile Asn Lys Leu Ile 
625                 630                 635                 640 


Ala Phe Leu Tyr Lys Glu Lys Arg Val Ile Arg Gln Val Gln Ile Pro 
                645                 650                 655     


Ser Phe Ser Arg Ile Leu Lys Arg Lys Ala Met Gln Asp Val Ile Asn 
            660                 665                 670         


Glu Ile Phe Lys Asp Asp Phe Asp Glu Asn Ile Val Asn Pro Glu Leu 
        675                 680                 685             


Lys Glu Lys Tyr Arg Asn Ser Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
    690                 695                 700                 


Tyr Asn Ala Phe Ile Ile Gln Pro Glu Leu Lys Glu Lys Phe Lys Asp 
705                 710                 715                 720 


Lys Ile Lys Thr Met Lys Ser Glu Leu Tyr Asn Lys Leu Lys Thr Ile 
                725                 730                 735     


Asp Lys Lys Glu Tyr Lys Ala Leu Tyr Cys Met Leu Ser Asn Glu Glu 
            740                 745                 750         


Ser Ala Leu Lys Asn Phe Ala Asp Arg Ile Tyr Ser Val Asp Gly Asp 
        755                 760                 765             


Asn Val Ser Phe Ala Asp Ile Cys Lys Ile Leu Met Thr Asp Tyr Asn 
    770                 775                 780                 


Met Gln Asn Gln Glu Lys Lys Asn Ile Glu Ser Met Glu Gln Lys Lys 
785                 790                 795                 800 


Lys Asn Lys Gly Lys Asp Glu Asn Tyr Lys His Phe Pro Leu Leu Leu 
                805                 810                 815     


His Lys Val Leu Lys Glu Leu Phe Ile Glu Tyr Leu Lys Gln Thr His 
            820                 825                 830         


Glu Leu Glu Phe Leu Arg Asn Asn Ile Cys Ile Lys Ser Asp Val Thr 
        835                 840                 845             


Met Glu Ser Phe Glu Ser Gln Ile Lys Gly Val Glu Ile Tyr Lys Asp 
    850                 855                 860                 


Leu Lys Glu Lys Ile Asp Lys Asn Asn Ser Leu Leu Asp Trp Tyr Val 
865                 870                 875                 880 


Ile Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asn 
                885                 890                 895     


Ile Lys Asn Tyr Ile Gln Phe Ala Thr Asn Ile Asp Lys Arg Ala Glu 
            900                 905                 910         


Ser Val Lys Asn Leu Thr Glu Ser Gly Met Val Lys Arg Ile Gln Tyr 
        915                 920                 925             


Tyr Asp Asp Ile Val Arg Thr Leu Glu Phe Ser Ala Gln Tyr Ile Gly 
    930                 935                 940                 


Lys Ile Ser Asn Asn Ile Asn Asp Tyr Phe Asn Ser Glu Asp Glu Tyr 
945                 950                 955                 960 


Val Ser Phe Leu Ser Lys Tyr Val Gly Phe Ile Asn Asp Lys Ser Glu 
                965                 970                 975     


Asp Val Leu Thr Glu Leu Lys Asp Phe Cys Arg Glu Lys Ile Asn Asn 
            980                 985                 990         


Gly Ser Gln Ile Ile Gly Ile Tyr  Tyr Gly Gly Asp Asn  Val Ile Ile 
        995                 1000                 1005             


Asn Arg  Asn Val Ile Tyr Ala  Gln Met Tyr Ser Asn  Ala Glu Val 
    1010                 1015                 1020             


Phe Ser  Asn Ile Tyr Lys Lys  Val Thr Lys Asn Asp  Ile Ile Asn 
    1025                 1030                 1035             


Tyr Tyr  Glu Lys Gln Asn Asp  Leu Lys Asp Val Phe  Lys Arg Gly 
    1040                 1045                 1050             


Val Cys  Gln Asn Glu Gly Glu  Gln Arg Ser Leu Cys  Glu Phe Gln 
    1055                 1060                 1065             


Gln Leu  Lys Asn Arg Ile Glu  Leu Thr Glu Leu Ser  Thr Tyr Ala 
    1070                 1075                 1080             


Asp Met  Val Asn Asp Phe Met  Ala Gln Phe Val Glu  Trp Ala Tyr 
    1085                 1090                 1095             


Leu Arg  Glu Arg Asp Leu Met  Tyr Phe Gln Leu Gly  Ile His Tyr 
    1100                 1105                 1110             


Ile Arg  Leu Phe Tyr Ser Asp  Asn Val Leu Asp Glu  Lys Tyr His 
    1115                 1120                 1125             


Lys Leu  Ser Asp Asn Val Ile  Asp Ile Glu Glu Gly  Ala Leu Leu 
    1130                 1135                 1140             


Tyr Gln  Ile Val Ala Met Tyr  Asp Tyr Glu Leu Arg  Ile Phe Glu 
    1145                 1150                 1155             


Thr Asp  Asn Ser Gly Asn Ala  Lys Arg Ile Gly Gln  Gly Gly Pro 
    1160                 1165                 1170             


Gly Lys  Ser Ile Pro Val Phe  Leu Lys Lys Tyr Cys  Asn Gly Thr 
    1175                 1180                 1185             


Asp Val  Tyr Glu Cys Gly Leu  Glu Leu Phe Glu Asp  Ile Asn Gln 
    1190                 1195                 1200             


His Glu  His Ile Ile Arg Phe  Arg Asn Asp Ile Ala  His Met Arg 
    1205                 1210                 1215             


Tyr Met  Ser Asn Gln Ala Met  Asn Ile Met Ser Ile  Val Ser Asn 
    1220                 1225                 1230             


Ile Tyr  Lys Ser Phe Phe Val  Tyr Asp Thr Lys Leu  Lys Lys Ser 
    1235                 1240                 1245             


Ile Ser  Leu Val Phe Lys Asn  Ile Leu Met Arg Tyr  Gly Val Ile 
    1250                 1255                 1260             


Ala Asp  Leu Val Phe Ser Tyr  Asn Asn Lys Asn Gln  Ser Ile Lys 
    1265                 1270                 1275             


Asp Asp  Met Asp Ile Asn Ile  Ile Asn Ile Lys Asn  Leu Lys Ser 
    1280                 1285                 1290             


Asp Lys  Tyr Val Tyr Lys Ile  Val Asn Glu Asp Ile  Val Lys Gln 
    1295                 1300                 1305             


Val Glu  Ile Glu Ile Arg Asn  Gln Val Phe Leu Glu  Gln Leu His 
    1310                 1315                 1320             


Asn Leu  Leu Tyr Phe Ser Arg  
    1325                 1330 


<210>  1153
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1153

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Lys Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn Gln Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Ile Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Asn Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Val Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Phe Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Gln Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Lys Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ala Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asp Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Ile Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Met Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Glu  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Ala Gln Gly  Gly Ala Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Arg Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Lys Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Met Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Cys Ile  Ser Ser Ile Lys Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Thr Leu Ile Thr Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Ser Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Gly Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  1154
<211>  1354
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1154

Leu Lys Trp Arg Lys Asn Met Lys Leu Ser Lys Val Thr Tyr Arg Val 
1               5                   10                  15      


Lys Asp Lys Asn Ala Lys Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala 
            20                  25                  30          


Val Ala Asn Asn Ser Glu Asn Ala Gly Gly Val Leu Tyr His Val Pro 
        35                  40                  45              


Gly Val Asp Leu Ile Asp Leu Arg Glu Gln Met Leu Asp Arg Asp Arg 
    50                  55                  60                  


Ser Val Arg Leu Leu Tyr Asn Ile Phe Asn His Ile Gln Thr Gly Thr 
65                  70                  75                  80  


Lys Pro Lys Lys Trp Gly Asn Asp Glu Thr Leu Ser Val Asp Glu Asn 
                85                  90                  95      


Glu Arg Lys Ala Lys Glu Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp 
            100                 105                 110         


Arg Glu Ala Cys Ser Glu Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn 
        115                 120                 125             


Ser Val Leu Phe Tyr Ser Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg 
    130                 135                 140                 


Met Asn Asp Asn Glu Ala Ile Ile Val Lys Met Gln Tyr Glu Asn Arg 
145                 150                 155                 160 


Leu Ser His Phe Thr Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr 
                165                 170                 175     


Leu Arg Asn Ser Leu Val Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp 
            180                 185                 190         


Ser Val Asn Ala Met Val Val Phe Ile Asn Asn Ile Gly Asn Gly Asn 
        195                 200                 205             


Ile Ser Asp Lys Asp Lys Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile 
    210                 215                 220                 


Arg Asn Asp Phe Ser Lys Leu Asn Pro Asn Val Gln Ser Ser Gln Gly 
225                 230                 235                 240 


Ala Asn Met Val Arg Ser Val Arg Asn Gln Asn Met Val Val Gln Pro 
                245                 250                 255     


Gln Gly Asp Lys Val Ser Phe Pro Leu Val Ser Asp Glu Gly Lys Asn 
            260                 265                 270         


Thr Val Thr Asn Lys Asn Val Glu Lys Lys Gly Leu Asn Glu Phe Leu 
        275                 280                 285             


Leu Asn Tyr Ala Asn Leu Asp Asp Glu Glu Arg Met Glu Lys Leu Arg 
    290                 295                 300                 


Lys Leu Arg Arg Ile Ile Asp Val Tyr Phe Ser Ser Pro Ser His Tyr 
305                 310                 315                 320 


Gln Lys Asp Met Asp Ile Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys 
                325                 330                 335     


Phe Asp Val Trp Lys Lys His Glu Thr Gly Lys Lys Asn Thr Glu Leu 
            340                 345                 350         


Phe Val Asp Ile Pro Asp Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile 
        355                 360                 365             


Lys Leu Asp Ala Val Leu Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp 
    370                 375                 380                 


Ser Ile Arg Lys Gln Asn Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val 
385                 390                 395                 400 


Val Glu Lys Tyr Asn Ser Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser 
                405                 410                 415     


Ile Asn Gln Tyr Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile 
            420                 425                 430         


Leu Lys Ser Cys Lys Ala Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr 
        435                 440                 445             


Leu Thr Glu Lys Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys 
    450                 455                 460                 


Tyr Ile Ala Leu Gly Lys Val Ile Tyr Asn Phe Thr Val Asp Asp Ile 
465                 470                 475                 480 


Trp Lys Asp Lys Lys Val Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile 
                485                 490                 495     


Lys His Gly Ile Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu 
            500                 505                 510         


Ala Leu Gln Arg Glu Leu Ala Val Asn Val Ala Phe Ala Ala Asn Asn 
        515                 520                 525             


Leu Ala Arg Ala Val Cys Asp Met Thr Asn Leu Lys Asp Lys Glu Ser 
    530                 535                 540                 


Asp Phe Leu Ile Trp Asn Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn 
545                 550                 555                 560 


Lys Asp Asp Met Ala Ser Val Ser Val Val Leu Gln Phe Phe Gly Gly 
                565                 570                 575     


Lys Ser Ser Trp Asp Ile Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn 
            580                 585                 590         


Lys Tyr Asn Tyr Glu Val Cys Phe Ile Asp Asp Leu Arg Lys Ala Val 
        595                 600                 605             


Tyr Ala Ala Arg Asn Glu Ser Phe His Phe Lys Thr Ala Leu Val Asn 
    610                 615                 620                 


Asn Asp Ile Trp Asn Thr Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu 
625                 630                 635                 640 


Thr Glu Ile Cys Leu Asp Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn 
                645                 650                 655     


Leu Pro Val Phe Tyr Ser Asp Asn Asp Leu Lys Lys Met Leu Asp His 
            660                 665                 670         


Leu Tyr Asn Asn Lys Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn 
        675                 680                 685             


Ser Val Met Val Arg Lys Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu 
    690                 695                 700                 


Lys Tyr Gln Lys Pro Gly Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr 
705                 710                 715                 720 


Ser Ala Cys Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu 
                725                 730                 735     


Gln Ser Asp Glu Ala Leu Ala Leu Phe Glu Glu Ser Val Asn Asn Leu 
            740                 745                 750         


Lys Gly Asp Asn Lys Asp Gln Glu Leu Ala Val Lys Asn Phe Arg Asn 
        755                 760                 765             


Asn Tyr Lys Asn Ile Lys Ser Ser Cys Thr Ser Phe Ser Gln Val Cys 
    770                 775                 780                 


Gln Met Tyr Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys 
785                 790                 795                 800 


Val Arg Ser Ser Lys Asp Ser Ile Val Asp Lys Pro Ile Tyr Gln His 
                805                 810                 815     


Tyr Lys Leu Leu Leu Lys Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr 
            820                 825                 830         


Leu Gln His Asn Glu Glu Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys 
        835                 840                 845             


Val Asn Cys Leu Lys Glu Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp 
    850                 855                 860                 


Thr Ser Lys Lys Tyr Val Ser Leu Cys Glu Glu Val Arg Lys Ser Pro 
865                 870                 875                 880 


Glu Leu Gln Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ser Arg Ser 
                885                 890                 895     


Leu Asn Leu Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn 
            900                 905                 910         


Asp Ile Lys Arg Arg Ala Asp Gly Ile Gly Asn Glu Leu His Val Ile 
        915                 920                 925             


Ala Gln Asn Leu Asp Val Val Asn Lys Trp Val Gln Val Ile Glu Val 
    930                 935                 940                 


Cys Leu Leu Leu Ser Ser Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe 
945                 950                 955                 960 


Tyr Asp Lys Asp Asp Tyr Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe 
                965                 970                 975     


Asp Asn Ser Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser 
            980                 985                 990         


Asp Gln Gly Lys Val Asp Leu Tyr  Val Asp Pro Ser Asn  Pro Lys Val 
        995                 1000                 1005             


Asn Arg  Asn Ile Val Gln Ser  Lys Leu Phe Ala Ala  Asp Tyr Ile 
    1010                 1015                 1020             


Leu Arg  Asp Ile Ile Glu Pro  Val Ser Lys Asp Glu  Ile Glu Asp 
    1025                 1030                 1035             


Phe Tyr  Asn Gln Lys Asp Glu  Ile Thr Thr Cys Lys  Ile Lys Gly 
    1040                 1045                 1050             


Ala Glu  Leu Thr Asp Glu Glu  Gln Lys Lys Ile Leu  Lys Tyr Gln 
    1055                 1060                 1065             


Lys Leu  Lys Asn Arg Val Glu  Leu Arg Asp Val Val  Glu Tyr Gly 
    1070                 1075                 1080             


Glu Ile  Ile Asn Glu Leu Leu  Gly Gln Leu Ile Asn  Trp Ser Phe 
    1085                 1090                 1095             


Met Arg  Glu Arg Asp Leu Leu  Tyr Phe Gln Leu Gly  Phe His Tyr 
    1100                 1105                 1110             


Asn Cys  Leu Arg Asn Asp Ser  Ala Lys Pro Glu Glu  Tyr Lys Asn 
    1115                 1120                 1125             


Leu Val  Leu Asp Asp Ile Ser  Ile Lys Asp Ala Ile  Leu His Gln 
    1130                 1135                 1140             


Ile Ile  Gly Val Tyr Val Asn  Gly Val Ala Ile Tyr  Ala Pro Gly 
    1145                 1150                 1155             


Lys Asp  Lys Asn Lys Leu Glu  Ser Gln Cys Val Lys  Gly Arg Val 
    1160                 1165                 1170             


Gly Gly  Lys Ile Gly Ala Phe  Cys Gly Tyr Ser Leu  Tyr Leu Lys 
    1175                 1180                 1185             


Leu Ala  Ala Asp Thr Leu Tyr  Asn Ala Gly Leu Glu  Val Phe Glu 
    1190                 1195                 1200             


Val Leu  Pro Glu His Glu Asp  Ile Ile Asn Leu Arg  Asn Gly Ile 
    1205                 1210                 1215             


Asp His  Phe Lys Phe Tyr Leu  Gly Gly Tyr Arg Ser  Ile Ile Ser 
    1220                 1225                 1230             


Leu Tyr  Ser Glu Val Phe Asp  Arg Phe Phe Thr Tyr  Asp Met Lys 
    1235                 1240                 1245             


Tyr Gln  Lys Asn Val Leu Asn  Leu Leu Gln Asn Ile  Leu Leu Arg 
    1250                 1255                 1260             


His Asn  Val Ile Ile Glu Pro  Ile Phe Glu Ser Gly  Ile Lys Lys 
    1265                 1270                 1275             


Ile Gly  Lys Asp Thr Lys Pro  Cys Ala Lys Leu Ser  Ile Arg Ser 
    1280                 1285                 1290             


Ile Ile  Ser Asp Ser Phe Glu  Tyr Lys Ile Lys Asp  Gly Asn Leu 
    1295                 1300                 1305             


Ile Ala  Asp Ala Lys Asp Lys  Arg Tyr Leu Glu Thr  Ile Lys Lys 
    1310                 1315                 1320             


Ile Leu  Phe Tyr Pro Glu Val  Glu Pro Glu Val Arg  Ile Leu Ser 
    1325                 1330                 1335             


Ser Lys  Asp Ser Phe Glu Gln  Asn Asn Gln Tyr Gly  Tyr Met Lys 
    1340                 1345                 1350             


Glu 
    


<210>  1155
<211>  1101
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1155

Met Arg Ile Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Ile Tyr Ser Glu 
            20                  25                  30          


Gln Ala Val Ser Asn Glu Thr Asn Asn Ile Leu Pro Val Lys Lys Met 
        35                  40                  45              


Asp Ser Phe Asn Leu Ser Ile Leu Asn Lys Thr Ile Ile Lys Phe Glu 
    50                  55                  60                  


Thr Val Lys Lys Gln Lys Leu Asn Leu Asp Gln Tyr Lys Ile Val Glu 
65                  70                  75                  80  


Lys Ile Phe Lys Tyr Pro Lys Gln Glu Leu Pro Lys Gln Ile Asn Ala 
                85                  90                  95      


Glu Glu Ile Leu Gln Phe Leu Asn His Lys Phe Gln Glu Pro Val Lys 
            100                 105                 110         


Tyr Trp Lys Asn Gly Lys Glu Glu Ser Phe Asn Leu Thr Leu Leu Ile 
        115                 120                 125             


Val Glu Ala Val Lys Thr Gln Glu Lys Arg Lys Leu Gln Pro Tyr Tyr 
    130                 135                 140                 


Asp Trp Lys Thr Trp Tyr Ile Gln Thr Lys Ser Asp Leu Leu Lys Lys 
145                 150                 155                 160 


Ser Ile Glu Asn Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg 
                165                 170                 175     


Lys Lys Ala Leu Leu Ala Trp Glu Thr Glu Phe Thr Thr Ser Gly Ser 
            180                 185                 190         


Ile Asp Leu Thr His Phe His Lys Val Tyr Met Thr Asp Val Leu Cys 
        195                 200                 205             


Thr Ala Leu Gln Lys Val Glu Pro Ser Ala Asp Glu Arg Gly Lys Met 
    210                 215                 220                 


Asn Ser Asn Ala Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Asn His 
225                 230                 235                 240 


Gln Pro Ala Ile Phe Gly Thr Arg Glu Ala Pro Asn Glu Val Asn Arg 
                245                 250                 255     


Ala Asp Asn Gln Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu 
            260                 265                 270         


Glu His Tyr Phe Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Ala Asp 
        275                 280                 285             


Asp Ile Ser His Tyr Leu Lys Ala Gln Thr Leu Lys Thr Thr Ile Glu 
    290                 295                 300                 


Lys Gln Leu Val Asn Ala Ile Arg Ala Asn Ile Ile Gln Gln Gly Lys 
305                 310                 315                 320 


Thr Asn His His Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile 
                325                 330                 335     


Arg Ile Lys Thr Asn Glu Ala Phe Val Leu Asn Leu Ile Gly Thr Cys 
            340                 345                 350         


Ala Phe Ala Ala Asn Asn Ile Arg Asn Met Val Asp Lys Glu Gln Ile 
        355                 360                 365             


Ser Asp Ile Leu Gly Lys Arg Glu Phe Ile Asp Ser Leu Thr Lys Ser 
    370                 375                 380                 


Arg Ile Ser Ser Gln Leu Tyr Ser Phe Phe Phe Gly Glu Asn Leu Ser 
385                 390                 395                 400 


Thr Asn Lys Ala Glu Lys Glu Thr Gln Leu Trp Gly Ile Arg Gly Ala 
                405                 410                 415     


Val Gln Gln Ile Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu 
            420                 425                 430         


Thr Thr Ile Phe Asn Ile Cys Lys Phe Glu Asn Pro Thr Asp Ala Asp 
        435                 440                 445             


Pro Lys Gln Gln Thr Asn Tyr Val Asp Ser Ile Tyr Lys Thr Leu Phe 
    450                 455                 460                 


Ile Lys Glu Leu Glu Lys Ile Pro Glu Ala Phe Ala Gln Gln Leu Lys 
465                 470                 475                 480 


Thr Gly Gly Ala Leu Ser Tyr Tyr Thr Val Glu Asn Leu Lys Thr Leu 
                485                 490                 495     


Leu Thr Thr Phe Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala 
            500                 505                 510         


Pro Gly Phe Lys Lys Val Leu Asn Gly Gly Ile Asn Tyr Gln Asn Ala 
        515                 520                 525             


Lys Gln Asp Glu Ser Phe Tyr Glu Leu Met Leu Glu Arg Tyr Leu Arg 
    530                 535                 540                 


Lys Glu Asn Phe Ala Glu Glu Ala Tyr Asn Ala Arg Tyr Phe Leu Leu 
545                 550                 555                 560 


Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Lys Phe Thr Ala Asp Arg 
                565                 570                 575     


Lys Ala Phe Ala Asp Ser Val Gly Phe Val Gln Leu Gln Asn Arg Lys 
            580                 585                 590         


Gln Ala Glu Asn Ser Lys Arg Pro Lys Ala Phe Ala Phe Glu Ala Val 
        595                 600                 605             


Arg Pro Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala Tyr Val 
    610                 615                 620                 


Gln Ser Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys Ala Thr 
625                 630                 635                 640 


Asp Glu Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val Phe Ile 
                645                 650                 655     


Lys Gly Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe Val Gln 
            660                 665                 670         


Val Pro Gln Pro Gln Leu Thr Thr Thr Asp Ser Asn Gln Gln Lys Ala 
        675                 680                 685             


Asp Lys Leu Asn Gln Leu Glu Ala Ser Ile Thr Ala Asp Cys Lys Leu 
    690                 695                 700                 


Thr Ala Gln Tyr Ala Lys Thr Asp Asp Ala Thr His Ile Ala Phe Tyr 
705                 710                 715                 720 


Val Phe Cys Lys Leu Leu Asp Ala Gly His Leu Ser Asn Leu Arg Asn 
                725                 730                 735     


Glu Leu Ile Lys Phe Arg Gly Ser Val Lys Asp Phe Asp Phe His His 
            740                 745                 750         


Leu Leu Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val Val Pro 
        755                 760                 765             


Thr Asp Tyr Arg Asp Leu Tyr Ser Ser Gly Ala Asp Cys Leu Ala Arg 
    770                 775                 780                 


Leu Arg Pro Phe Ile Glu Gln Gly Ala Asp Ile Lys Asn Trp Ser Asp 
785                 790                 795                 800 


Leu Tyr Val Gln Thr Asp Lys Gln Thr Pro Val Ile His Ala Gly Ile 
                805                 810                 815     


Glu Leu Ser Val Lys Tyr Gly Thr Thr Ala Leu Leu Glu Gln Leu Ile 
            820                 825                 830         


Thr Cys Asn Pro Lys Phe Arg Val Met Glu Asp Asn Phe Thr Lys Trp 
        835                 840                 845             


Ser Ala Gln Lys Lys Glu Ile Glu Glu Lys Val Asn Lys His Thr Asn 
    850                 855                 860                 


Leu His Gln Gln Trp Val Glu Ala Lys Glu Lys Asp Asp Arg Glu Arg 
865                 870                 875                 880 


Val Lys Ser Lys Lys Asn Phe Val Arg Glu Tyr Val Lys Lys Asn Tyr 
                885                 890                 895     


Val Asp Tyr Ile Asn Asn Cys Ile Glu Ile Asn Asn Tyr Asn Trp Leu 
            900                 905                 910         


Asp Asn Lys Leu His Phe Val His Leu Asn His Leu His His Leu Thr 
        915                 920                 925             


Ile Asp Ile Leu Gly Arg Met Ala Gly Phe Val Ala Leu Trp Glu Arg 
    930                 935                 940                 


Asp Phe Gln Tyr Ile Thr Lys Tyr Thr Ala Ala Lys Glu Gly Thr Asp 
945                 950                 955                 960 


Ala Leu Ser Phe Asp Gly Gly Leu Pro Arg Leu Lys Asp Lys Gln Glu 
                965                 970                 975     


Tyr Tyr Asn Lys Leu Phe Leu Ser Asp Lys Tyr Thr Lys Val Arg Asn 
            980                 985                 990         


His Ile Ala His Phe Asn Tyr Leu  Thr Lys Asp Ala Ala  Asp Phe Ala 
        995                 1000                 1005             


Leu Leu  Asp Leu Ile Asn Glu  Leu Arg Glu Leu Leu  His Tyr Gly 
    1010                 1015                 1020             


Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ala Phe Ile  Asp Leu Phe 
    1025                 1030                 1035             


Glu Lys  His Gly Met Ile Leu  Lys Leu Lys Leu Asn  Thr Asp His 
    1040                 1045                 1050             


Gln Leu  Val Val Glu Ser Ile  Glu Pro Lys Lys Ile  Tyr His Leu 
    1055                 1060                 1065             


Gly Ser  Thr Ala Lys Asp Lys  Pro Glu Tyr Gln Tyr  Thr Thr Asn 
    1070                 1075                 1080             


Gln Val  Met Thr Val Tyr Cys  Asn Met Cys Arg Ser  Leu Leu Glu 
    1085                 1090                 1095             


Met Lys  Lys 
    1100     


<210>  1156
<211>  1388
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1156

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Arg Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn His Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Lys Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Lys Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Asp Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Val Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Ser Ile  Arg Ser Ile Ile Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Asn Leu Ile Ala Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Arg  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Glu Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Lys Lys Asn Lys Lys  Asn Asn Gly Asn Arg  Asp Glu Lys 
    1355                 1360                 1365             


Lys Asn  Ser Asp Gly Leu Thr  Tyr Asn Pro Phe Leu  Asn Leu Pro 
    1370                 1375                 1380             


Phe Glu  Leu Pro Glu 
    1385             


<210>  1157
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1157

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Tyr Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Ser Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Val Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Val 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Lys Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Lys Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Leu Lys Glu Leu Lys Glu Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn Tyr Thr Met Gln Gln Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Lys Lys Asp Glu Lys Phe Asn Asp Glu Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Asn Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asp  Thr Glu Lys Ile Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Glu Leu  Lys Lys Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  Asn Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Met Asn Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Val Thr Phe Lys  Ile Glu Lys Asp Lys  Lys Ile Arg 
    1100                 1105                 1110             


Ile Glu  Ser Leu Lys Ser Glu  Glu Val Val His Leu  Lys Lys Leu 
    1115                 1120                 1125             


Lys Leu  Lys Asp Asn Asp Lys  Lys Lys Glu Pro Ile  Lys Thr Tyr 
    1130                 1135                 1140             


Arg Asn  Ser Lys Glu Leu Cys  Lys Leu Val Lys Val  Met Phe Glu 
    1145                 1150                 1155             


Tyr Lys  Met Lys Glu Lys Lys  Ser Glu Asn 
    1160                 1165             


<210>  1158
<211>  1391
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1158

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Lys Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn Gln Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Glu 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Ile Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Asn Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Val Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Phe Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Gln Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asn Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Glu Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ser Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asn Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe Tyr Asp Lys Asp Asp Tyr 
945                 950                 955                 960 


Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe Asp Asn Ser Asp Met Pro 
                965                 970                 975     


Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser Asp Gln Gly Lys Val Asp 
            980                 985                 990         


Leu Tyr Val Asp Pro Ser Asn Pro  Lys Val Asn Arg Asn  Ile Val Gln 
        995                 1000                 1005             


Ser Lys  Leu Phe Ala Ala Asp  Tyr Ile Leu Arg Asp  Ile Ile Glu 
    1010                 1015                 1020             


Pro Val  Ser Lys Asp Glu Ile  Glu Asp Phe Tyr Asn  Gln Lys Asp 
    1025                 1030                 1035             


Glu Ile  Thr Thr Cys Lys Ile  Lys Gly Ala Glu Leu  Thr Asp Glu 
    1040                 1045                 1050             


Glu Gln  Lys Lys Ile Leu Lys  Tyr Gln Lys Leu Lys  Asn Arg Val 
    1055                 1060                 1065             


Glu Leu  Arg Asp Val Val Glu  Tyr Gly Glu Ile Ile  Asn Glu Leu 
    1070                 1075                 1080             


Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met Arg Glu  Arg Asp Leu 
    1085                 1090                 1095             


Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn Cys Leu  Arg Asn Asp 
    1100                 1105                 1110             


Ser Ala  Lys Pro Glu Glu Tyr  Lys Asn Leu Val Leu  Asp Asp Ile 
    1115                 1120                 1125             


Ser Ile  Lys Asp Ala Ile Leu  His Gln Ile Ile Gly  Met Tyr Val 
    1130                 1135                 1140             


Asn Gly  Val Ala Ile Tyr Ala  Pro Gly Lys Asp Lys  Asn Lys Leu 
    1145                 1150                 1155             


Glu Ser  Gln Cys Val Lys Gly  Arg Val Gly Gly Lys  Ile Gly Ala 
    1160                 1165                 1170             


Phe Cys  Gly Tyr Ser Leu Tyr  Leu Lys Leu Ala Ala  Asp Thr Leu 
    1175                 1180                 1185             


Tyr Asn  Ala Gly Leu Glu Val  Phe Glu Val Leu Pro  Glu His Glu 
    1190                 1195                 1200             


Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp His Phe  Lys Phe Tyr 
    1205                 1210                 1215             


Leu Gly  Gly Tyr Arg Ser Ile  Ile Ser Leu Tyr Ser  Glu Val Phe 
    1220                 1225                 1230             


Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr Gln Lys  Asn Val Leu 
    1235                 1240                 1245             


Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His Asn Val  Ile Ile Glu 
    1250                 1255                 1260             


Pro Ile  Phe Glu Ser Gly Ile  Lys Lys Ile Gly Lys  Asp Thr Lys 
    1265                 1270                 1275             


Pro Cys  Ala Lys Leu Cys Ile  Ser Ser Ile Lys Ser  Asp Ser Phe 
    1280                 1285                 1290             


Glu Tyr  Lys Ile Lys Asp Gly  Thr Leu Ile Thr Asp  Ala Lys Asp 
    1295                 1300                 1305             


Lys Gly  Tyr Leu Glu Thr Ile  Lys Lys Ile Leu Phe  Tyr Pro Glu 
    1310                 1315                 1320             


Val Glu  Pro Glu Val Arg Ile  Leu Ser Ser Lys Asp  Ser Phe Glu 
    1325                 1330                 1335             


Gln Asn  Asn Gln Tyr Gly Tyr  Met Lys Gly Lys Ser  Glu Asn Asn 
    1340                 1345                 1350             


Lys Asn  Asn Lys Asn Lys Lys  Asn Lys Lys Asn Asn  Gly Asn Arg 
    1355                 1360                 1365             


Asp Glu  Lys Lys Asn Ser Asp  Gly Leu Thr Tyr Ser  Pro Phe Phe 
    1370                 1375                 1380             


Asp Leu  Pro Phe Glu Leu Pro  Glu 
    1385                 1390     


<210>  1159
<211>  1247
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1159

Met His Val Met Val Ile Ser Leu Ile Ile Val Glu Ile Gly Pro Ile 
1               5                   10                  15      


Glu Ile Lys Ala Asn Leu Phe Gln Arg Glu Trp Ser Asp Ile Val Pro 
            20                  25                  30          


Ile Val His Leu Tyr Leu Trp Lys Pro Pro Trp Tyr Cys Leu Gln Leu 
        35                  40                  45              


Leu Thr Ala Phe Ile Leu Ser Leu Ser Val Arg Phe Leu Met Lys Tyr 
    50                  55                  60                  


Val Lys Pro Tyr Gly Arg Ser Lys Thr Val Leu Val Glu Gly Lys Lys 
65                  70                  75                  80  


Thr Arg Leu Leu Ser Arg Arg Lys Lys Gly Asn Glu Val Glu Thr Ser 
                85                  90                  95      


Ser Phe Asp Ala Phe Tyr Ala Ser Asp Pro Ser Phe Val Leu Ser Arg 
            100                 105                 110         


Leu Ile Ser Glu Phe Asp Lys Val Ala Ala Lys Pro Arg Gln Gly Glu 
        115                 120                 125             


Leu Pro Ser Lys Arg Gln Phe Gln Phe Arg Ser Asp Leu Gly Ala Glu 
    130                 135                 140                 


Ile Trp Glu His Phe Lys Leu Lys Pro Trp Phe Thr Asp Lys Pro Glu 
145                 150                 155                 160 


Tyr Trp Ala Lys Leu Trp Lys Thr Lys Leu His Pro Tyr Gly Arg Glu 
                165                 170                 175     


Val Lys Asp Asp Pro Lys Thr Ala Pro Asn Arg Arg Pro Ala Lys Asp 
            180                 185                 190         


Glu Arg Gln Gly Arg Leu Tyr Lys Lys Tyr Phe Gly Ile Thr Pro Pro 
        195                 200                 205             


Asp Gln Ile Asn Ala Ala Ser Leu Pro Ser Met Ile Glu Gln Glu Leu 
    210                 215                 220                 


Phe Val His Gly Thr Thr Gly Ala Gly Asp Thr Pro Gly Gly Gly Val 
225                 230                 235                 240 


Gly Gln Arg Gly Lys Ile Thr Gln His Ala Arg Thr Leu Ser Ser Asn 
                245                 250                 255     


Ala His Ser Leu Glu Arg Val Lys Gly Thr Ala Ala Pro Trp Glu Ala 
            260                 265                 270         


Met Asp Leu Glu Asp Tyr Lys Asn Tyr Gly Asp Val Ala Gly Glu Ile 
        275                 280                 285             


Ile Gln Ala Leu Lys Val Lys Lys Glu Lys Pro Lys Ser Gly Arg Ser 
    290                 295                 300                 


Ala Lys Pro Phe Thr Pro Ser Pro Ala Phe Phe Ala Ser Ile Leu His 
305                 310                 315                 320 


Asp His Tyr Ala Arg Val Phe Gln Arg Asp Glu Val Arg Pro Gly Ser 
                325                 330                 335     


Asn Gln Glu Pro Met Ser Ile Lys Glu Val Lys Gln Asn Ala Ala Tyr 
            340                 345                 350         


Thr Gly Leu Phe Glu Leu His Glu Ala Ile Cys Asp Phe Tyr Lys Asn 
        355                 360                 365             


Ala Ala Arg Ser Arg Asn Arg Gln Leu Asp Ser Met Ile Val Ala Leu 
    370                 375                 380                 


Pro Lys Asn Met Asp Asp Leu Phe Lys Arg Leu Arg Met Arg Arg Val 
385                 390                 395                 400 


Asn Gln Ser Leu Asn Ser Met Ile Arg Leu Gly Lys Val Ile His Tyr 
                405                 410                 415     


Ser Ala Ala Ser Ser Glu Asp Glu Asp Ser Pro Arg Asp Val Val Lys 
            420                 425                 430         


Asn Trp Pro Ser Asp Ile Asp Asn Ser Pro Tyr Trp Leu Ser Glu Gly 
        435                 440                 445             


Met Ala Lys Ile Lys Arg Asn Glu Ala Phe Val Arg Val Trp Arg Thr 
    450                 455                 460                 


Ala Ile Ser His Ala Ala His Gly Leu Arg Thr Trp Val Ala Ile Asp 
465                 470                 475                 480 


Gly His Glu Val Asp Gly Leu Pro Val Asp Leu Leu Leu Gln Asp Gly 
                485                 490                 495     


Arg Glu Phe Ile Ser Asn Phe Phe Glu Asn Glu Leu Phe Gln Lys Gln 
            500                 505                 510         


Ala Gly Phe Tyr Phe Gly Asp Arg Ala Lys His Phe Gly Thr Asn Ala 
        515                 520                 525             


Asp Glu Arg Glu Ala Gly Leu Lys Leu Met Ala Phe Thr Leu Ser Arg 
    530                 535                 540                 


Tyr Arg Asn Ser Gly Phe His Phe Asn Gly Arg Gly Gly Phe Val Arg 
545                 550                 555                 560 


Met Leu Lys Pro Gln Glu Asp Gln Asn Tyr Gln Gly Ser Asp Val Phe 
                565                 570                 575     


Leu Asn Ile Leu Asn Glu Asp Val Ala Arg Leu Glu Glu Arg Asn Lys 
            580                 585                 590         


Glu Val Leu Arg Ala Val Gln Ile Glu Thr Phe Thr Lys Gln His Glu 
        595                 600                 605             


Leu Asp Lys Ile Tyr Glu Glu Ile Ser Gln Gly Arg Gly Ser Gly Thr 
    610                 615                 620                 


Leu Ala Pro Arg Phe Asn Arg Val Leu Gln Arg Val Lys Asn Ala Trp 
625                 630                 635                 640 


Thr Lys Glu Lys Leu Pro Lys Asp Ile Asp Thr Lys Thr Ala Leu Arg 
                645                 650                 655     


Leu Pro Asp Pro Arg Asn His Ile Asp Leu Lys Asn Pro Val Leu Lys 
            660                 665                 670         


Ala Gln Tyr Leu Ala Leu Lys Leu Val Tyr Glu Thr Gly Phe Arg His 
        675                 680                 685             


Trp Met Thr His Lys Val Gly Ala Asp Leu Thr Pro Trp Ile Asp Gln 
    690                 695                 700                 


Ala Val Lys Arg Ala His Ala Ala Met Lys Glu Leu Asn Asp Gln Asn 
705                 710                 715                 720 


Asp Glu Phe Glu Ile Val Thr Lys Ile Ala Gly Leu Val Glu Leu Gly 
                725                 730                 735     


Ala Glu Asp Ser Ile Glu Glu Phe His Asp Gln Leu Ala Glu Lys Ala 
            740                 745                 750         


Ala Ala Val Ser Pro Leu Gln Ser Asn Tyr Ser Asn Glu Gln Asp Lys 
        755                 760                 765             


Met Ser Arg Gln Ser Ser His Ile Asp Asp Leu Arg Thr Asp Val Phe 
    770                 775                 780                 


Ala Ile Ala Phe Glu Asp Tyr Leu Lys Glu Gln Gly Phe Glu Phe Leu 
785                 790                 795                 800 


Leu Thr Leu Pro Lys Glu Arg Asp Thr Gly Leu Gly Ala Gly Ala Ala 
                805                 810                 815     


Leu Ile Asp Asp Leu Pro Arg Val Asp Thr Asn Pro Val Gly Trp Asp 
            820                 825                 830         


Leu Tyr His Gly Arg Leu Tyr Ala Ile Leu His Leu Ile Pro Ala Gly 
        835                 840                 845             


Thr Val Asn Ala Leu Ala His Gln Leu Arg Lys Trp Glu Val Leu Asp 
    850                 855                 860                 


Thr Arg Gly Glu Ala Leu His Leu Lys Thr Leu Glu Thr Asn Pro Glu 
865                 870                 875                 880 


Glu Lys Asp Ala Thr Leu Arg Val Arg Glu Leu Leu Asp Leu Tyr Leu 
                885                 890                 895     


Thr Met Arg Asp Asp Lys Phe Thr Glu Gly Ala Trp Ile Asp Val Gly 
            900                 905                 910         


Glu Glu Leu Arg Glu Val Phe Asp Ser Glu Glu Thr Met Arg Arg Val 
        915                 920                 925             


Phe Pro Thr Ala Ser Ala Glu Thr Asp Glu His Ile Pro Ile Arg Gly 
    930                 935                 940                 


Leu Arg Glu Leu Leu Arg Thr Gly Ser His Glu Val Leu Gly Gln Ile 
945                 950                 955                 960 


Tyr Gln Lys His Lys Ile Thr Ser Arg Asp Leu Glu Lys Leu Gly Ala 
                965                 970                 975     


Phe Ser Lys Ser Asn Val Glu Asn Leu His Lys Ser Tyr Gly Asp Leu 
            980                 985                 990         


His Ala Asp Trp Val Glu Lys Lys  Lys Glu Phe Lys Glu  Ile Glu Lys 
        995                 1000                 1005             


Tyr Asn  Asp Ile Ala Gln Gln  Leu Asp Ala Tyr Arg  Ser Ile Arg 
    1010                 1015                 1020             


Asn Phe  Val Gln Leu Asn Thr  His Leu Arg Thr Tyr  Arg Leu Met 
    1025                 1030                 1035             


Met Asp  Val Val Gly Arg Phe  Val Asp Leu Ala Gly  Met Phe Glu 
    1040                 1045                 1050             


Arg Asp  Val Tyr Phe Val Met  Leu Ala Leu Ile Tyr  Arg Ala Gly 
    1055                 1060                 1065             


Gly Asp  Ser Gln Asn Ala Leu  Glu Thr Val Phe Glu  Asn Glu Gly 
    1070                 1075                 1080             


Lys Gly  Met Leu Lys Ser Gly  Arg Val Phe Ala Ala  Cys Ser His 
    1085                 1090                 1095             


Phe Leu  Glu Pro Glu Asp Lys  Gln His Val Val Leu  Thr Arg Leu 
    1100                 1105                 1110             


Glu Ile  Phe Phe Gly Lys Lys  Phe Trp Asp Ser Gly  Gln Pro Glu 
    1115                 1120                 1125             


Ser Glu  Val Gly Gln Val Asn  Arg Arg Pro Val Lys  Ala Arg Asn 
    1130                 1135                 1140             


Asp Phe  Ala His Phe Asn Val  Leu Leu Val Gln Glu  Asn Asn Lys 
    1145                 1150                 1155             


Phe Lys  Thr Pro Asn Leu Thr  His Leu Met Asn Arg  Ala Arg Asp 
    1160                 1165                 1170             


Met Val  Ala Tyr Asp Arg Lys  Leu Arg Asn Ser Leu  Ser Lys Ser 
    1175                 1180                 1185             


Ile Ser  Asp Leu Leu Ala Lys  Ser Gly Leu Gln Ile  Ser Trp Asn 
    1190                 1195                 1200             


Thr Asp  Lys His Thr Leu Val  Asp Ala Lys Val Ser  Ser Leu Glu 
    1205                 1210                 1215             


Ile Asn  His Leu Gly Gly Met  Gly Arg Thr Glu Lys  Leu Asn Asn 
    1220                 1225                 1230             


Ala Gln  Phe Val Ala Met Val  Gly Glu Leu Phe Ala  Pro Glu 
    1235                 1240                 1245         


<210>  1160
<211>  1000
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1160

Met Ala Leu Lys Tyr Arg Ala Ala Val Asn Tyr Leu Ala Asp Glu Val 
1               5                   10                  15      


Gly Lys Thr Val Leu Gly Glu Ile Arg Glu Lys Lys Val Arg Ser Cys 
            20                  25                  30          


Ala Asp Leu Tyr Trp Ile Glu Tyr Ile Asp Ser Thr Val Glu Lys Leu 
        35                  40                  45              


Leu Leu Lys Ser Arg Asn Lys Asp Gly Tyr Arg Tyr Glu Ile Gly Phe 
    50                  55                  60                  


Leu Ser Lys His Ile Trp Lys Glu Trp Thr Gln Tyr Ile Ser Gly Lys 
65                  70                  75                  80  


Tyr Ile Glu Met Gly Lys Gly Val Tyr His Phe Ala Ile Pro Asp Leu 
                85                  90                  95      


Ser Gly Asn Leu Glu Gly Glu Pro Ile Ser Ile Cys Glu Val Lys Pro 
            100                 105                 110         


Glu Tyr Arg Asn Gly Val Ser Gly Phe Asp Tyr Glu Arg Ile Arg Ala 
        115                 120                 125             


Glu Glu Ser Leu Glu Arg Glu Met Glu Lys Tyr Val Leu Phe Ala Val 
    130                 135                 140                 


Asn Asn Phe Ala Arg Ala Val Thr Pro Glu Glu Glu Arg Glu Lys Ser 
145                 150                 155                 160 


Gly His Glu Asp Val Leu Leu Met Lys Thr Leu Ser Glu Ile Glu Glu 
                165                 170                 175     


Ser Gln Thr Lys Glu Glu Arg Gln Lys Lys His Asp Asn Asn Val Lys 
            180                 185                 190         


Asn Ala Ile Thr Leu Tyr Ala Asp Ala Asp Arg Arg Ile Leu Gln Phe 
        195                 200                 205             


Phe Gly Gly Gln Ser Arg Phe Arg Glu Lys Glu Asp Ser Leu Ile Asn 
    210                 215                 220                 


Leu Tyr Ser Gly Glu Asp Leu Tyr Lys Glu Ile Arg Lys Glu Leu Tyr 
225                 230                 235                 240 


Ala Ile Arg Asn Ile Thr Phe His Tyr Thr Thr Lys Ala Asp Lys Asp 
                245                 250                 255     


Gln Thr Gln Lys His Asp Leu Ala Glu Tyr Leu Phe Glu Glu Glu Phe 
            260                 265                 270         


Ser Asp Ile Thr Glu Leu Phe Arg Glu Lys Tyr Tyr Ala Asn Asn Val 
        275                 280                 285             


Trp Lys Tyr Tyr Asp Val Glu Val Ile Asn Thr Ile Met Glu Asn Ile 
    290                 295                 300                 


Tyr Cys Gly Arg Lys Tyr Arg Ala Ala Gln Val Pro Ala Phe Lys Asn 
305                 310                 315                 320 


Ile Ile Ser Arg Pro Glu Leu Pro Gln Val Met Asn Gly Phe Val Lys 
                325                 330                 335     


Gly Asn Ser Leu Arg Arg Leu Met Asn Cys Pro Asp Arg Asp Val Ile 
            340                 345                 350         


Asn Lys Tyr Trp Ser Ala Leu Phe Phe Val Leu Lys Glu Leu Tyr Tyr 
        355                 360                 365             


Tyr Asp Phe Leu Gln Glu Gln Lys Lys Pro Glu Asp Asn Val Lys Glu 
    370                 375                 380                 


Arg Phe Phe Arg Ala Ile Glu Lys Leu Ser Gly Gln Glu Asn Asp Asp 
385                 390                 395                 400 


Lys Lys Gln Lys Ala Trp Glu Ser Phe Gly Asn Arg Ile Asp Gln Ile 
                405                 410                 415     


Gly Arg Asp Arg Ser Phe Gly Ala Ile Cys Gln Gly Leu Met Ile Glu 
            420                 425                 430         


Tyr Met Leu Gln Asn Ser Asp Ile Ser Met Val Gln Thr Glu Thr Asp 
        435                 440                 445             


Asn Gly Lys Ala Asn Asn Lys Lys Gln Ile Tyr Lys His Tyr Arg Thr 
    450                 455                 460                 


Leu Leu Tyr Asn Cys Ile Arg Glu Ala Phe Ile Glu Tyr Leu Arg Glu 
465                 470                 475                 480 


Lys Trp Glu Glu Leu Arg Thr Pro Val Leu Thr Val Lys Glu Trp Ser 
                485                 490                 495     


Lys Glu Glu Phe Cys Arg Ala Asp Gly Leu Lys His Leu Ser Leu Phe 
            500                 505                 510         


Asp His Leu Lys Lys Thr Phe Asn Asp Ala Glu Ser Gly Ser Ser Trp 
        515                 520                 525             


Tyr Met Ala Ala His Phe Ile Asn Gln Lys Tyr Leu Asn His Leu Leu 
    530                 535                 540                 


Gly Ser Ile Arg Asn Tyr Leu Gln Phe Thr Glu Asp Ile Glu Asp Arg 
545                 550                 555                 560 


Ala Ile Ser Leu Gly Asp Cys Val Asp Asn Lys Arg Glu Glu Lys Asn 
                565                 570                 575     


Leu Arg Tyr Arg Asn Thr Leu Glu Ile Leu Glu Phe Val Ala Gln Phe 
            580                 585                 590         


Cys Glu Arg Thr Thr Asn Val Met Glu Asp Tyr Phe Glu Ser Asn Gln 
        595                 600                 605             


Glu Tyr Ala Glu Tyr Leu Ser Gly Phe Val Asp Tyr Asn Thr Thr Lys 
    610                 615                 620                 


Lys Glu Thr Asp Ile Glu Lys Ala Leu Tyr Ser Phe Cys Lys Gln Lys 
625                 630                 635                 640 


Phe Lys Val Asp Gly Lys Glu Tyr Met Ala Gly Ile Tyr Tyr Asp Gly 
                645                 650                 655     


Glu Asn Leu Ile Pro Asn Arg Asn Ile Ile Arg Ala Asn Met Tyr Gly 
            660                 665                 670         


Asn Thr Ser Cys Leu Lys Pro Cys Met Asp Arg Ile Thr Leu Lys Glu 
        675                 680                 685             


Ile Arg Thr Met Tyr Ala Asp Gln Asn Lys Leu Asp Leu Val Leu Lys 
    690                 695                 700                 


Glu Gly Val Cys His Thr Glu Glu Glu Gln Lys Ala Tyr Arg Glu Tyr 
705                 710                 715                 720 


Gln Asn Glu Lys Asn Arg Ile Glu Leu Phe Asp Val Cys Thr Tyr Thr 
                725                 730                 735     


Gln Ile Leu Asn Asp Met Gln Ala Arg Leu Ile Gly Trp Ser Tyr Met 
            740                 745                 750         


Arg Glu Arg Asp Leu Met Tyr Tyr Gln Leu Gly Tyr Tyr Tyr Thr Lys 
        755                 760                 765             


Leu Phe Trp Thr Asp Ser Ile Ser Glu Glu Asp Ala Arg Arg Arg Leu 
    770                 775                 780                 


Val Gly Asn Leu Val Asn Val Glu Asp Gly Ala Ile Leu Tyr Gln Ile 
785                 790                 795                 800 


Leu Ala Phe Asn Ser Tyr Asn Leu Pro Ile Ile Ala Asn Lys Asn Asn 
                805                 810                 815     


Thr Val Thr Leu Leu Lys Asp Glu Gly Ser Ile Gly Gly Lys Ala Ile 
            820                 825                 830         


Thr Ala Phe Phe Lys Asn Tyr Glu Asn Ala Glu Met Ile Tyr Glu Glu 
        835                 840                 845             


Ala Leu Asp Leu Phe Glu Asn Met Asp Glu His Ala Ala Ile Ile Asn 
    850                 855                 860                 


Thr Arg Asn Tyr Ile Glu His Phe Lys Tyr Phe Ile Lys Ser Asp Arg 
865                 870                 875                 880 


Ser Met Met Asp Leu Tyr Ser Glu Ile Tyr Asp Arg Phe Phe Arg His 
                885                 890                 895     


Asp His Asn Arg Lys Lys Asn Val Pro Asp Ser Leu Lys Asn Val Leu 
            900                 905                 910         


Ala Asp Asn Phe Met Ile Val Asp Ile Asp Met Glu Leu Gly Ser Lys 
        915                 920                 925             


Lys Val Gly Glu Lys Lys Lys Gly Phe Arg Glu His Lys Ala Ala Arg 
    930                 935                 940                 


Ile Glu Phe Thr Asp Ser Gly Ile Arg Ser Thr Asp Met Thr Tyr Thr 
945                 950                 955                 960 


Ile Lys Pro Asp Ile Lys Asp Asn Lys Lys Asp Lys Lys Val Leu Val 
                965                 970                 975     


Pro Ala Arg Ser Glu Val Phe Leu Lys Gln Phe Arg Lys Ile Leu Glu 
            980                 985                 990         


Tyr Arg Ile Gln Asp Lys Ile Gln  
        995                 1000 


<210>  1161
<211>  1284
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1161

Met Ile Ile Gly Gly Ile Asn Met Lys Leu Thr Arg Arg Arg Ile Ser 
1               5                   10                  15      


Gln Glu Arg Lys Asn Gln Lys Leu Thr Ala Ala Phe Tyr Arg Asp Met 
            20                  25                  30          


Asp His Gly Leu Leu Tyr Val Asp Ser Glu Asp Glu Asp Arg Thr Glu 
        35                  40                  45              


Tyr Val Val Ser Ser Met Asp Phe Glu Arg Ser Trp Arg Gly Arg Ile 
    50                  55                  60                  


Leu Lys Asn Gly Glu Asp Asn Lys Asn Pro Phe Tyr Glu Phe Val Lys 
65                  70                  75                  80  


Gly Leu Val Gly Ser Asn Glu Ile Ile Cys Lys Pro Ile Thr Asn Asp 
                85                  90                  95      


Asn Asn Thr Asp Ile Asn Glu Lys Ile Lys Lys Tyr Ile Thr Glu Phe 
            100                 105                 110         


Gly Arg Asn Leu Lys Ala Pro Gly Ser Glu Val Thr Leu Glu Lys Leu 
        115                 120                 125             


Ile Leu Asn Ile Gln Ser Gly Thr Ser Glu Asn Glu Val Arg Pro Glu 
    130                 135                 140                 


Leu Glu Lys Ile Lys Asp Met Ile Lys Lys Asp Ile Glu Lys Arg Lys 
145                 150                 155                 160 


Asp Glu Leu Ile Lys Ser Ile Thr Asn Asn His Ile Pro Phe Met Leu 
                165                 170                 175     


Asp Glu Asp Lys Leu Val Pro Ser Thr Lys Lys Met Lys Trp Leu Tyr 
            180                 185                 190         


Lys Phe Leu Asn Gly Pro Asp Lys Ser Leu Asn Leu Gln Met Phe Asp 
        195                 200                 205             


Glu Tyr Trp Thr Lys Tyr Gly Tyr Lys Asn Leu Glu Glu Lys Ile Ile 
    210                 215                 220                 


Lys Glu Ile Asn Ser Leu Pro Glu Lys Asn Ala Arg Ser Ile Ser Arg 
225                 230                 235                 240 


Ala Val Ser Lys Thr Val Arg Glu Tyr Asn Arg Asn Phe Arg Ile Asn 
                245                 250                 255     


Tyr Met Val Pro Glu Asn Glu Asn Ala Glu Ala Asp Ser Asp Tyr Glu 
            260                 265                 270         


Gly Phe Leu Leu Phe Leu Lys Ala Val Glu Gln His Phe Lys Lys Tyr 
        275                 280                 285             


Tyr Pro Val Lys Ser Lys Asp Ser Asn Glu Val Arg Asp Lys Asn Leu 
    290                 295                 300                 


Cys Glu Glu Lys Asn Tyr Lys Phe Tyr Cys Ser Tyr Asn Phe Val Lys 
305                 310                 315                 320 


Asn Glu Val Lys Arg Ser Ile Ile Asn Gln Leu Val Ser Gly Leu Ile 
                325                 330                 335     


Gln Gln Gly Lys Leu Leu His Tyr Phe Tyr Lys Asp Gly Ile Trp Gln 
            340                 345                 350         


Gln Asp Phe Leu Asn Ser Tyr Gly Leu Ser Tyr Ile Gln Val Glu Glu 
        355                 360                 365             


Ser Phe Lys Lys Ser Leu Met Thr Ser Leu Ser Trp Gly Ile Asn Arg 
    370                 375                 380                 


Leu Thr Ser Phe Phe Ile Asp Val Gly Thr Asp Glu Asn Glu Glu Lys 
385                 390                 395                 400 


Thr Val Gln Asn Lys Lys Gln Lys Asn Asn Arg Lys Ile Asp Asp Ile 
                405                 410                 415     


Leu Ser Asp Lys Ser Asn Leu Arg Ala Ile Phe Asn Asp Leu Arg Ser 
            420                 425                 430         


Asn Thr Glu Leu Gln Lys His Phe Lys Glu Lys Leu Ala Phe Cys Tyr 
        435                 440                 445             


Pro Ile Phe Ile Lys Val Lys Lys Glu Lys Met Phe Asp Asp Ile Glu 
    450                 455                 460                 


Lys Leu Ile Lys Leu Val Glu Glu Ala Arg Glu Ser Val Ala Tyr Leu 
465                 470                 475                 480 


Arg His Arg Cys Phe His Tyr Lys Asp Val Thr Ile Thr Glu Met Leu 
                485                 490                 495     


Lys Ala Leu Asn Asn Asn Thr Glu Thr Asp Lys Thr Glu Asp Ile Asp 
            500                 505                 510         


Tyr Ser Val Ala Ala Glu Tyr Phe Leu Arg Asp Ile Asn Asn Leu Tyr 
        515                 520                 525             


Asp Ala Phe Arg Glu Gln Ile Arg Ser Ser Gly Ile Ala Asp Tyr Tyr 
    530                 535                 540                 


Pro Ala Asp Ile Ile Ser Gly Cys Phe Lys Lys Cys Gly Leu Gln Phe 
545                 550                 555                 560 


Val Leu Tyr Ser Pro Gln Asn Ser Leu Met Pro Ser Phe Lys Asn Ile 
                565                 570                 575     


Tyr Lys Arg Gly Ser Asn Leu Tyr Lys Ala Tyr Gln Glu Glu Lys Glu 
            580                 585                 590         


Gln Lys Asp Lys Glu Tyr Lys Arg His Asn Thr Asn Ile Val Gln Glu 
        595                 600                 605             


Glu Ser Lys Glu Leu Ser Trp Tyr Ile Glu Val Ser Asp Thr Glu Gln 
    610                 615                 620                 


Gly Lys Thr Ala Tyr Arg Asn Leu Leu Gln Leu Ile Tyr Tyr His Ala 
625                 630                 635                 640 


Phe Leu Pro Glu Val Arg Glu Asn Glu Ser Leu Ile Thr Val Tyr Phe 
                645                 650                 655     


Ala Lys Thr Lys Glu Trp Asn Arg Lys Val Ala Glu Thr Lys Ala Lys 
            660                 665                 670         


Lys Lys Asn Ala Gly Lys Thr Tyr Lys Asp Lys Pro Ile Arg Ala Tyr 
        675                 680                 685             


Arg Tyr Glu Ala Ile Pro Asp Tyr Val Gly Glu Arg Leu Asp Asp Tyr 
    690                 695                 700                 


Phe Lys Ile Leu Gln Arg Glu Gln Met Ala Lys Ala Lys Asp Val Asn 
705                 710                 715                 720 


Glu Gly Asn Ala Glu Asn Asn Asn Tyr Ile Gln Phe Ile Arg Asp Val 
                725                 730                 735     


Val Val Trp Ala Phe Gly Ala Tyr Leu Glu Glu Arg Leu Glu Lys Tyr 
            740                 745                 750         


Lys Lys Asp Leu Gln Ser Ser His Ser Gln Lys Asp Lys Lys Asp Val 
        755                 760                 765             


Asn Asp Ala Leu Lys Glu Leu Phe Pro Asp Asp Lys Asp Lys Arg Gln 
    770                 775                 780                 


Phe Phe Met Lys Cys Lys Phe Thr Asp Val Leu Ile Asn Asp Val Gly 
785                 790                 795                 800 


Glu Asn Asn Gln Ile Thr Glu Met Glu Asp Leu Glu Thr Ser Lys Glu 
                805                 810                 815     


Gln Gln Asn Arg Glu Ile Lys Arg Lys Asp Leu Leu Cys Phe Tyr Leu 
            820                 825                 830         


Phe Leu Arg Leu Leu Asp Glu Arg Glu Ile Ser Gly Leu Lys His Gln 
        835                 840                 845             


Phe Val Arg Tyr Arg Cys Ser Leu Lys Glu Arg Arg Leu Pro Asp Asn 
    850                 855                 860                 


Arg Lys Asp Val Asp Glu Glu Ile Val Leu Leu Glu Glu Leu Glu Glu 
865                 870                 875                 880 


Leu Met Glu Leu Val Ser Tyr Thr Met Pro Ser Val Pro Glu Leu Ser 
                885                 890                 895     


Gly Lys Ala Glu Ser Gly Leu Asp Leu Val Ile Ser Lys Tyr Phe Lys 
            900                 905                 910         


Asp Phe Phe Glu Lys Ser Ala Leu Lys Asn Gln Asp Ile Met Lys Leu 
        915                 920                 925             


Tyr Tyr Gln Ser Asp Asn Lys Thr Pro Val Phe Arg Lys Tyr Met Ala 
    930                 935                 940                 


Leu Leu Met Arg Ser Ala Pro Leu Gln Leu Tyr Lys Asp Met Phe Arg 
945                 950                 955                 960 


Asn Tyr Tyr Ile Ile Thr Glu Lys Glu Cys Gln Glu Tyr Ile Lys Thr 
                965                 970                 975     


Ser Gln Asp Ile Asp Ala Phe Gln Cys Lys Leu Asn Glu Leu His Lys 
            980                 985                 990         


Glu Leu Glu His Val Arg Leu Lys  Ser Val Glu Asp Lys  Lys Gly Lys 
        995                 1000                 1005             


Ile Phe  Tyr Tyr Leu Ala Gly  Ser Asp Ala Glu Arg  Val Lys Glu 
    1010                 1015                 1020             


Tyr Glu  Asp Thr Leu Ser Lys  Val Val Arg Tyr Lys  Arg Leu Gln 
    1025                 1030                 1035             


His Lys  Leu Thr Phe Glu Ser  Leu Tyr Thr Ile Phe  Lys Ile His 
    1040                 1045                 1050             


Val Asp  Ile Ala Ala Arg Met  Val Gly Tyr Thr Glu  Asp Trp Glu 
    1055                 1060                 1065             


Arg Asp  Met Leu Phe Leu Phe  Lys Ser Leu Glu Tyr  Asn Glu Lys 
    1070                 1075                 1080             


Leu Asn  Glu Gly Val Val Glu  Lys Ile Phe Asn Asn  Lys Asp Glu 
    1085                 1090                 1095             


Lys Gly  His Ile Val Lys Lys  Leu Lys Asp Asn Leu  Asn Ser Glu 
    1100                 1105                 1110             


Asp Lys  Glu Lys Ile Gly Ile  Leu Cys Trp His Lys  Glu Ile Thr 
    1115                 1120                 1125             


Asp Lys  Asn Phe Val Glu Ile  Ile Trp Ile Arg Asn  Pro Ile Ala 
    1130                 1135                 1140             


His Leu  Asn His Phe Met Gln  Thr Val Lys Asn Pro  Lys Arg Ser 
    1145                 1150                 1155             


Leu Glu  Lys Met Ile Asn Ala  Leu Cys Val Leu Leu  Ser Tyr Asp 
    1160                 1165                 1170             


Arg Lys  Arg Gln Asn Ser Val  Thr Lys Thr Ile Asn  Asp Leu Leu 
    1175                 1180                 1185             


Leu Asn  Glu Tyr His Val Lys  Ile Lys Trp Lys Arg  Trp Val Asp 
    1190                 1195                 1200             


Lys Asn  Cys Asn Ile Tyr Tyr  Tyr Ile Asp Glu Gln  Asn Ile Glu 
    1205                 1210                 1215             


Asn Glu  Pro Ile Leu His Ile  Lys His Leu His Met  Gly Glu Lys 
    1220                 1225                 1230             


Cys His  Val Asn Arg Asn Ala  Asp Met Phe Asp Arg  Gln Lys Glu 
    1235                 1240                 1245             


Trp Leu  Arg Asn Gly Ile Thr  Glu Glu Val Tyr Asp  Lys Ser Met 
    1250                 1255                 1260             


Leu Gly  Cys Ile Cys Arg Leu  Phe Lys Phe Asp Tyr  Asn Asp Leu 
    1265                 1270                 1275             


Tyr Gly  Ala Asn Arg Gln 
    1280                 


<210>  1162
<211>  1284
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1162

Met Ile Ile Gly Gly Ile Asn Met Lys Leu Thr Arg Arg Arg Ile Ser 
1               5                   10                  15      


Gln Glu Arg Lys Asn Gln Lys Leu Thr Ala Ala Phe Tyr Arg Asp Met 
            20                  25                  30          


Asp His Gly Leu Leu Tyr Val Asp Ser Glu Asp Glu Asp Arg Thr Glu 
        35                  40                  45              


Tyr Val Val Ser Ser Met Asp Phe Glu Arg Ser Trp Arg Gly Arg Ile 
    50                  55                  60                  


Leu Lys Asn Gly Glu Asp Asn Lys Asn Pro Phe Tyr Glu Phe Val Lys 
65                  70                  75                  80  


Gly Leu Val Gly Ser Asn Glu Ile Ile Cys Lys Pro Ile Thr Asn Asp 
                85                  90                  95      


Asn Asn Thr Asp Ile Asn Glu Lys Ile Lys Lys Tyr Ile Thr Glu Phe 
            100                 105                 110         


Gly Arg Asn Leu Lys Ala Pro Gly Ser Glu Val Thr Leu Glu Lys Leu 
        115                 120                 125             


Ile Leu Asn Ile Gln Ser Gly Thr Ser Glu Asn Glu Val Arg Pro Glu 
    130                 135                 140                 


Leu Glu Lys Ile Lys Asp Met Ile Lys Lys Asp Ile Glu Lys Arg Lys 
145                 150                 155                 160 


Asp Glu Leu Ile Lys Ser Ile Thr Asn Asn His Ile Pro Phe Met Leu 
                165                 170                 175     


Asp Glu Asp Lys Leu Val Pro Ser Thr Lys Lys Met Lys Trp Leu Tyr 
            180                 185                 190         


Lys Phe Leu Asn Gly Pro Asp Lys Ser Leu Asn Leu Gln Met Phe Asp 
        195                 200                 205             


Glu Tyr Trp Thr Lys Tyr Gly Tyr Lys Asn Leu Glu Glu Lys Ile Ile 
    210                 215                 220                 


Lys Glu Ile Asn Ser Leu Pro Glu Lys Asn Ala Arg Ser Ile Ser Arg 
225                 230                 235                 240 


Ala Val Ser Lys Thr Val Arg Glu Tyr Asn Arg Asn Phe Arg Ile Asn 
                245                 250                 255     


Tyr Met Val Pro Glu Asn Glu Asn Ala Glu Ala Asp Ser Asp Tyr Glu 
            260                 265                 270         


Gly Phe Leu Leu Phe Leu Lys Ala Val Glu Gln His Phe Lys Lys Tyr 
        275                 280                 285             


Tyr Pro Val Lys Ser Lys Asp Ser Asn Glu Val Arg Asp Lys Asn Leu 
    290                 295                 300                 


Cys Glu Glu Lys Asn Tyr Lys Phe Tyr Cys Ser Tyr Asn Phe Val Lys 
305                 310                 315                 320 


Asn Glu Val Lys Arg Ser Ile Ile Asn Gln Leu Val Ser Gly Leu Ile 
                325                 330                 335     


Gln Gln Gly Lys Leu Leu His Tyr Phe Tyr Lys Asp Gly Ile Trp Gln 
            340                 345                 350         


Gln Asp Phe Leu Asn Ser Tyr Gly Leu Ser Tyr Ile Gln Val Glu Glu 
        355                 360                 365             


Ser Phe Lys Lys Ser Leu Met Thr Ser Leu Ser Trp Gly Ile Asn Arg 
    370                 375                 380                 


Leu Thr Ser Phe Phe Ile Asp Val Gly Thr Asp Glu Asn Glu Glu Lys 
385                 390                 395                 400 


Thr Val Gln Asn Lys Lys Gln Lys Asn Asn Arg Lys Ile Asp Asp Ile 
                405                 410                 415     


Leu Ser Asp Lys Ser Asn Leu Arg Ala Ile Phe Asn Asp Leu Arg Ser 
            420                 425                 430         


Asn Thr Glu Leu Gln Lys His Phe Lys Glu Lys Leu Ala Phe Cys Tyr 
        435                 440                 445             


Pro Ile Phe Ile Lys Val Lys Lys Glu Lys Met Phe Asp Asp Ile Glu 
    450                 455                 460                 


Lys Leu Ile Lys Leu Val Glu Glu Ala Arg Glu Ser Val Ala Tyr Leu 
465                 470                 475                 480 


Arg His Arg Cys Phe His Tyr Lys Asp Val Thr Ile Thr Glu Met Leu 
                485                 490                 495     


Lys Ala Leu Asn Asn Asn Thr Glu Thr Asp Lys Thr Glu Asp Ile Asp 
            500                 505                 510         


Tyr Ser Val Ala Ala Glu Tyr Phe Leu Arg Asp Ile Asn Asn Leu Tyr 
        515                 520                 525             


Asp Ala Phe Arg Glu Gln Ile Arg Ser Ser Gly Ile Ala Asp Tyr Tyr 
    530                 535                 540                 


Pro Ala Asp Ile Ile Ser Gly Cys Phe Lys Lys Cys Gly Leu Gln Phe 
545                 550                 555                 560 


Val Leu Tyr Ser Pro Gln Asn Ser Leu Met Pro Ser Phe Lys Asn Ile 
                565                 570                 575     


Tyr Lys Arg Gly Ser Asn Leu Tyr Lys Ala Tyr Gln Glu Glu Lys Glu 
            580                 585                 590         


Gln Lys Asp Lys Glu Tyr Lys Arg His Asn Thr Asn Ile Val Gln Glu 
        595                 600                 605             


Glu Ser Lys Glu Leu Ser Trp Tyr Ile Glu Val Ser Asp Thr Glu Gln 
    610                 615                 620                 


Gly Lys Thr Ala Tyr Arg Asn Leu Leu Gln Leu Ile Tyr Tyr His Ala 
625                 630                 635                 640 


Phe Leu Pro Glu Val Arg Glu Asn Glu Ser Leu Ile Thr Val Tyr Phe 
                645                 650                 655     


Ala Lys Thr Lys Glu Trp Asn Arg Lys Val Ala Glu Thr Lys Ala Lys 
            660                 665                 670         


Lys Lys Asn Ala Gly Lys Thr Tyr Lys Asp Lys Pro Ile Arg Ala Tyr 
        675                 680                 685             


Arg Tyr Glu Ala Ile Pro Asp Tyr Val Gly Glu Arg Leu Asp Asp Tyr 
    690                 695                 700                 


Phe Lys Ile Leu Gln Arg Glu Gln Met Ala Lys Ala Lys Asp Val Asn 
705                 710                 715                 720 


Glu Gly Asn Ala Glu Asn Asn Asn Tyr Ile Gln Phe Ile Arg Asp Val 
                725                 730                 735     


Val Val Trp Ala Phe Gly Ala Tyr Leu Glu Glu Arg Leu Glu Lys Tyr 
            740                 745                 750         


Lys Lys Asp Leu Gln Ser Ser His Ser Gln Lys Asp Lys Lys Asp Val 
        755                 760                 765             


Asn Asp Ala Leu Lys Glu Leu Phe Pro Asp Asp Lys Asp Lys Arg Gln 
    770                 775                 780                 


Phe Phe Met Lys Cys Lys Phe Thr Asp Val Leu Ile Asn Asp Val Gly 
785                 790                 795                 800 


Glu Asn Asn Gln Ile Thr Glu Met Glu Asp Leu Glu Thr Ser Lys Glu 
                805                 810                 815     


Gln Gln Asn Arg Glu Ile Lys Arg Lys Asp Leu Leu Cys Phe Tyr Leu 
            820                 825                 830         


Phe Leu Arg Leu Leu Asp Glu Arg Glu Ile Ser Gly Leu Lys His Gln 
        835                 840                 845             


Phe Val Arg Tyr Arg Cys Ser Leu Lys Glu Arg Arg Leu Pro Asp Asn 
    850                 855                 860                 


Arg Lys Asp Val Asp Glu Glu Ile Val Leu Leu Glu Glu Leu Glu Glu 
865                 870                 875                 880 


Leu Met Glu Leu Val Ser Tyr Thr Met Pro Ser Val Pro Glu Leu Ser 
                885                 890                 895     


Gly Lys Ala Glu Ser Gly Leu Asp Leu Val Ile Ser Lys Tyr Phe Lys 
            900                 905                 910         


Asp Phe Phe Glu Lys Ser Ala Leu Lys Asn Gln Asp Ile Met Lys Leu 
        915                 920                 925             


Tyr Tyr Gln Ser Asp Asn Lys Thr Pro Val Phe Arg Lys Tyr Met Ala 
    930                 935                 940                 


Leu Leu Met Arg Ser Ala Pro Leu Gln Leu Tyr Lys Asp Met Phe Arg 
945                 950                 955                 960 


Asn Tyr Tyr Ile Ile Thr Glu Lys Glu Cys Gln Glu Tyr Ile Lys Thr 
                965                 970                 975     


Ser Gln Asp Ile Asp Ala Phe Gln Cys Lys Leu Asn Glu Leu His Lys 
            980                 985                 990         


Glu Leu Glu His Val Arg Leu Lys  Ser Val Glu Asp Lys  Lys Gly Lys 
        995                 1000                 1005             


Ile Phe  Tyr Tyr Leu Ala Gly  Ser Asp Ala Glu Arg  Val Lys Glu 
    1010                 1015                 1020             


Tyr Glu  Asp Thr Leu Ser Lys  Val Val Arg Tyr Lys  Arg Leu Gln 
    1025                 1030                 1035             


His Lys  Leu Thr Phe Glu Ser  Leu Tyr Thr Ile Phe  Lys Ile His 
    1040                 1045                 1050             


Val Asp  Ile Ala Ala Arg Met  Val Gly Tyr Thr Glu  Asp Trp Glu 
    1055                 1060                 1065             


Arg Asp  Met Leu Phe Leu Phe  Lys Ser Leu Glu Tyr  Asn Glu Lys 
    1070                 1075                 1080             


Leu Asn  Glu Gly Val Val Glu  Lys Ile Phe Asn Asn  Lys Asp Glu 
    1085                 1090                 1095             


Lys Gly  His Ile Val Lys Lys  Leu Lys Asp Asn Leu  Asn Ser Glu 
    1100                 1105                 1110             


Asp Lys  Glu Lys Ile Gly Ile  Leu Cys Trp His Lys  Glu Ile Thr 
    1115                 1120                 1125             


Asp Lys  Asn Phe Val Glu Ile  Ile Trp Ile Arg Asn  Pro Ile Ala 
    1130                 1135                 1140             


His Leu  Asn His Phe Met Gln  Thr Val Lys Asn Pro  Lys Arg Ser 
    1145                 1150                 1155             


Leu Glu  Lys Met Ile Asn Ala  Leu Cys Val Leu Leu  Ser Tyr Asp 
    1160                 1165                 1170             


Arg Lys  Arg Gln Asn Ser Val  Thr Lys Thr Ile Asn  Asp Leu Leu 
    1175                 1180                 1185             


Leu Asn  Glu Tyr His Val Lys  Ile Lys Trp Lys Arg  Trp Val Asp 
    1190                 1195                 1200             


Lys Asn  Cys Asn Ile Tyr Tyr  Tyr Ile Asp Glu Gln  Asn Ile Glu 
    1205                 1210                 1215             


Asn Glu  Pro Ile Leu His Ile  Lys His Leu His Met  Gly Glu Lys 
    1220                 1225                 1230             


Cys His  Val Asn Arg Asn Ala  Asp Met Phe Asp Arg  Gln Lys Glu 
    1235                 1240                 1245             


Trp Leu  Arg Asn Gly Ile Thr  Glu Glu Val Tyr Asp  Lys Ser Met 
    1250                 1255                 1260             


Leu Gly  Cys Ile Cys Arg Leu  Phe Lys Phe Asp Tyr  Asn Asp Leu 
    1265                 1270                 1275             


Tyr Gly  Ala Asn Arg Gln 
    1280                 


<210>  1163
<211>  920
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1163

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Gly Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu 
        915                 920 


<210>  1164
<211>  1366
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1164

Met Lys Leu Ser Lys Glu Asn His Ile Arg Ser Ala Val Val Ile Ser 
1               5                   10                  15      


Gly Lys Glu Gly Asn Ile Ala Gly Thr Leu Tyr Lys Ile Pro Gly Glu 
            20                  25                  30          


Gly Thr Val Asp Leu Lys Lys Arg Met Leu Glu Arg Asp Lys Ala Val 
        35                  40                  45              


Lys Ser Leu Tyr Asn Ile Phe Asn Gln Ile Gln Leu Gly Asn Glu Pro 
    50                  55                  60                  


Lys Glu Trp Lys Glu Asn Arg Asn Leu Ser Thr Glu Glu Asn Thr Arg 
65                  70                  75                  80  


Arg Met His Gln Lys Lys Val Lys Ile Gln Asn Tyr Lys Met Lys Lys 
                85                  90                  95      


Ala Cys Ser Arg Tyr Val Asn Thr Ile Ser Arg Thr Ile Asn Glu Leu 
            100                 105                 110         


Leu Phe Phe Tyr Lys Thr Thr Lys Thr Thr Gln Asn Asn Lys Val Lys 
        115                 120                 125             


Tyr Asp Lys Leu Lys Met Met His Lys Asn Glu Asp Ile Ile Ser Lys 
    130                 135                 140                 


Met Lys Asn Glu Asn Ile Leu Gln Gln Phe Lys Val Glu Gly Lys Asn 
145                 150                 155                 160 


Gly Lys Leu Glu Lys Gly Lys Leu Glu Asp Phe Val Thr Leu Ala Leu 
                165                 170                 175     


Arg Ser Ser Leu Val Val Ser Arg Tyr Lys Gly Lys Asp Phe Asp Ser 
            180                 185                 190         


Val Ala Ala Val Ala Val Phe Leu Glu Asn Ile Gly Asn Asn Asn Ile 
        195                 200                 205             


Ser His Glu Asp Glu Arg Thr Ile Asn Ile Leu Leu Asp Leu Ile Arg 
    210                 215                 220                 


Glu Asp Phe Thr Lys Leu Asn Pro Asn Ile Asp Asn Thr Met Gly Ala 
225                 230                 235                 240 


Arg Leu Ile Arg Ser Val Thr Asn Gln Asn Met Leu Val Gln Pro Gln 
                245                 250                 255     


Asn Asp Arg Phe Ser Phe Pro Cys Val His Asp Ser Gly Lys Ser Lys 
            260                 265                 270         


Val Ser Asn Lys Asn Val Glu Lys Ser Gly Leu Asp Asn Phe Leu Leu 
        275                 280                 285             


Asp Tyr Ala Asn Leu Asp Lys Asp Ile Arg Glu Asn Tyr Leu Arg Lys 
    290                 295                 300                 


Leu Arg Arg Ile Ile Asp Ile Tyr Phe Ser Ala Pro Ile Thr Tyr Gln 
305                 310                 315                 320 


Lys Asp Met Asp Val Ala Leu Ser Glu Val Val Val Lys Asp Lys Phe 
                325                 330                 335     


Asp Val Trp Lys Lys His Asn Glu Gly Lys Lys Asp Ser Asn Thr Phe 
            340                 345                 350         


Val Lys Val Pro Glu Val Leu Ile Lys Ala Glu Arg Asp His Glu Lys 
        355                 360                 365             


Leu Asp Thr Val Ile Glu Lys Gln Ala Arg Lys Glu Leu Ala Asp Arg 
    370                 375                 380                 


Val Arg Lys Gln Asn Met Thr Cys Tyr Arg Tyr Thr Gln Ala Val Val 
385                 390                 395                 400 


Lys Lys Tyr Asn Ala Lys Glu Ala Leu Phe Phe Glu Asn Asp Asp Ile 
                405                 410                 415     


Asn Gln Tyr Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu 
            420                 425                 430         


Lys Ser Cys Lys Ile Gly Thr Leu Phe Lys Leu His Asn Gly Tyr Leu 
        435                 440                 445             


Ile Glu Lys Val Trp Lys Asp Val Ile Asn Leu Ile Ser Ile Lys Tyr 
    450                 455                 460                 


Ile Ala Leu Gly Lys Val Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp 
465                 470                 475                 480 


Asn Asp Asn Lys Val Lys Arg Leu Gly Asp Ile Ser Glu Lys Ile Arg 
                485                 490                 495     


Ser Gly Ile Thr Ser Phe Asp Tyr Glu Met Leu Lys Ala Gln Glu Thr 
            500                 505                 510         


Leu Gln Arg Glu Leu Ala Val Asn Val Ala Phe Ser Ala Asn Asn Leu 
        515                 520                 525             


Ala Arg Ala Val Cys Asn Met Ser Asp Leu Ser Asp Lys Thr Ser Asp 
    530                 535                 540                 


Phe Leu Leu Trp Gln Pro Asp Asp Ile Asn Asn Lys Met Lys Lys Ser 
545                 550                 555                 560 


Thr Gly Asn Asp Glu Asn Asn Glu Lys Asn Lys Arg Ala Val Cys Ala 
                565                 570                 575     


Val Leu Gln Phe Phe Gly Gly Lys Ser Leu Trp Asn Val Val Asp Phe 
            580                 585                 590         


Glu Lys Ala Tyr Lys Asn Ala Gly Lys His Gly Tyr Gly Val Tyr Phe 
        595                 600                 605             


Ile Asn Asp Leu Arg Lys Ala Ile Phe Ala Ala Arg Asn Glu Ser Phe 
    610                 615                 620                 


His Phe Lys Thr Ala Ser Val Asn Asn Glu Lys Trp Asp Val Glu Phe 
625                 630                 635                 640 


Leu Gly Arg Met Phe Glu Lys Glu Thr Glu Phe Cys Leu Asp Ile Glu 
                645                 650                 655     


Lys Glu Arg Phe Tyr Ser Asn Asn Leu Pro Met Phe Tyr Lys Ser Ser 
            660                 665                 670         


Asn Leu Glu Lys Met Leu Asn His Phe Tyr Ser Lys Asn Ile Ser Arg 
        675                 680                 685             


Thr Ala Gln Val Leu Ser Tyr Asn Thr Val Phe Val Arg Lys Thr Phe 
    690                 695                 700                 


Pro Glu Tyr Leu Asn Asn Val Leu Lys Tyr Lys Lys Pro Gly Thr Asp 
705                 710                 715                 720 


Ala Glu Ile Leu Asp Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu Leu Lys 
                725                 730                 735     


Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Lys Asp Ala Phe Lys Tyr 
            740                 745                 750         


Phe Glu Asn Ala Val Tyr Asn Leu Asn Ser Lys Asn Ile Asn His Asp 
        755                 760                 765             


Ser Leu Gly Lys Lys Leu Asn Arg Asp Glu Met Lys Arg Lys Lys Ala 
    770                 775                 780                 


Ala Glu Ser Phe Gln Arg Arg Phe Val Glu Ile Lys Arg Val Ser Asp 
785                 790                 795                 800 


Ser Ser Ile Ser Tyr Val Cys Gln Val Phe Met Thr Asp Tyr Asn Gln 
                805                 810                 815     


Gln Asn Asn Gln Asn Lys Lys Val Arg Ser Ser Asn Asp Ser Leu Leu 
            820                 825                 830         


Asp Lys Pro Ile Tyr Gln His Phe Lys Met Leu Leu Lys Glu Thr Ile 
        835                 840                 845             


Lys Ser Ala Phe Ala Ala Tyr Leu Lys Asp Asn Asn Asn Lys Asp Leu 
    850                 855                 860                 


Phe Gly Phe Ile Gly Glu Pro Leu Lys Ile Asn Lys Asn Asp Asp Val 
865                 870                 875                 880 


Lys Val Ile Lys Lys Glu Glu Phe Leu Pro Asp Trp Lys Ser Glu Lys 
                885                 890                 895     


Tyr Ser Leu Leu Ile Glu Lys Val Lys Lys Ser Pro Lys Leu Gln Met 
            900                 905                 910         


Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met 
        915                 920                 925             


Ala Gly Ser Met Arg Ser Tyr Leu Gln Tyr Val Ser Asp Ile Asn Lys 
    930                 935                 940                 


Arg Ala Asn Val Met Gly Ser Lys Leu His Val Glu Val Leu Asp Lys 
945                 950                 955                 960 


Asp Thr Val Lys Asp Trp Ile Gln Val Ile Glu Val Cys Leu Leu Leu 
                965                 970                 975     


Ala Ser Arg Thr Ser Asn Gln Phe Asp Asp Tyr Phe Asn Asp Gly Asp 
            980                 985                 990         


Asp Tyr Ala Gly Tyr Leu Lys Ser  Tyr Val Asp Phe Ser  Asp Glu Asn 
        995                 1000                 1005             


Met Pro  Ser Ala Tyr Ser Ala  Leu Val Tyr Phe Ser  Asp Gln Gly 
    1010                 1015                 1020             


Lys Ile  Asp Leu Tyr Val Asp  Pro Lys Asn Pro Lys  Ile Asn Arg 
    1025                 1030                 1035             


Asn Ile  Val Gln Ser Lys Leu  Phe Ala Ala Asp His  Ile Leu Gly 
    1040                 1045                 1050             


Asn Gly  Arg Ile Val Gln Pro  Val Ser Lys Asp Asp  Ile Val Glu 
    1055                 1060                 1065             


Phe Tyr  Asn Leu Lys Ala Lys  Ile Ala Asp Ser Lys  Ile Lys Gly 
    1070                 1075                 1080             


Glu Asn  Ile Ser Glu Lys Glu  Gln Arg Asn Ile Ile  Arg Tyr Gln 
    1085                 1090                 1095             


Arg Leu  Lys Asn Lys Val Glu  Leu Arg Asp Ile Val  Glu Tyr Gly 
    1100                 1105                 1110             


Glu Ile  Ile Asn Glu Leu Leu  Gly Gln Leu Ile Asn  Trp Ser Phe 
    1115                 1120                 1125             


Met Arg  Glu Arg Asp Leu Leu  Tyr Phe Gln Leu Gly  Phe His Tyr 
    1130                 1135                 1140             


Asn Cys  Leu Arg Asn Asn Ser  Glu Lys Pro Glu Glu  Tyr Lys Arg 
    1145                 1150                 1155             


Ile Glu  Ala Asp Asp Ile Ser  Ile Asn Asp Ala Val  Leu Tyr Gln 
    1160                 1165                 1170             


Ile Ile  Gly Met Tyr Val Asn  Gly Ile Pro Val Tyr  Thr Ser Asp 
    1175                 1180                 1185             


Asn Asn  Lys Leu Lys Gly Lys  Cys Val Asn Gly Gly  Ala Gly Gly 
    1190                 1195                 1200             


Lys Ile  Ala Ala Val Cys Glu  Tyr Ser Glu Tyr Leu  Gly Phe Lys 
    1205                 1210                 1215             


Lys Ala  Thr Leu Tyr Glu Ser  Gly Leu Glu Val Phe  Glu Val Leu 
    1220                 1225                 1230             


Ala Glu  His Asp Asp Ile Ile  Lys Leu Arg Asn Gly  Ile Glu His 
    1235                 1240                 1245             


Phe Lys  Tyr Tyr Leu Gly Asn  Tyr Arg Ser Ile Met  Ser Leu Tyr 
    1250                 1255                 1260             


Ser Glu  Val Phe Asp Arg Phe  Phe Thr Tyr Asp Leu  Lys Tyr Gln 
    1265                 1270                 1275             


Lys Asn  Val Leu Asn Leu Leu  Gln Asn Ile Leu Leu  Arg His Asn 
    1280                 1285                 1290             


Ile Val  Ile Val Pro Glu Phe  Glu Ser Gly Thr Lys  Lys Val Gly 
    1295                 1300                 1305             


Lys Asn  Ile Lys Gln Ala Ala  Lys Ile Ser Ile Lys  Asn Ile Gln 
    1310                 1315                 1320             


Ser Asp  Lys Phe Thr Tyr Lys  Ile Lys Gly Gly Thr  Ala Ser Ile 
    1325                 1330                 1335             


Asp Ala  Lys Asp Asp Arg Tyr  Leu Glu Thr Ile Lys  Lys Ile Leu 
    1340                 1345                 1350             


Tyr Tyr  Pro Glu Tyr Asp Lys  Asp Ser Gly Gly Val  Cys 
    1355                 1360                 1365     


<210>  1165
<211>  1170
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1165

Met Lys Ile Thr Lys Asn Thr Lys Asn Gly Lys Leu Glu Phe Tyr Arg 
1               5                   10                  15      


Asp Val Lys Glu Gly Gly Leu Arg Asp Pro Lys Ser Lys Thr Ile Trp 
            20                  25                  30          


Thr Ser Glu Thr Ile Lys Arg Leu Asp Ile Asn Lys Ser Leu Lys Gly 
        35                  40                  45              


Arg Ile Leu Ala Tyr Gly Thr Ser Leu Gly Ser Ser Asn Pro Tyr Ser 
    50                  55                  60                  


Val Phe Val Asp Ser Leu Ile Arg Glu Asn Lys Glu Ile Ser Leu Ser 
65                  70                  75                  80  


Glu Leu Lys Arg Glu Gln Cys Lys Lys Glu Asn Val Gln Lys Tyr Leu 
                85                  90                  95      


Ser Ala Tyr Gly Arg Met Ile Asn Tyr Cys Thr Glu Glu Asn Thr Ser 
            100                 105                 110         


Leu Gly Asn Leu Leu Val Glu Tyr Gly Asn Gly Ala Glu Ile Ser Glu 
        115                 120                 125             


Ala Leu Val Gln Ile Lys Lys Gln Ile Leu Lys Leu Lys Arg His Lys 
    130                 135                 140                 


Lys Lys Ser Leu Leu Asp Ser Phe Met Asn Asn Lys Ile Pro Phe Lys 
145                 150                 155                 160 


Leu Thr Asn Gly Lys Leu Glu Pro Ala Thr Asp Lys Met Ser Arg Leu 
                165                 170                 175     


Phe Ser Leu Leu Glu Glu Asp Gly Val Asp Lys Asn Lys Phe Glu Lys 
            180                 185                 190         


Tyr Lys Thr Trp Tyr Gln Tyr Glu Val Leu Lys Lys Arg Leu Asp Leu 
        195                 200                 205             


Ile Cys Glu Glu His Phe Ser Ala Ala Glu Arg Lys Pro Arg Val Leu 
    210                 215                 220                 


Ala Lys Lys Ile Tyr Ser Ala Val Lys Leu Tyr Asn Lys Glu Lys Ala 
225                 230                 235                 240 


Asn Ser Asp Val Ile Lys Asn Lys Asp Asp Ala His Ser Leu Phe Leu 
                245                 250                 255     


Asp Glu Ile Arg Asp His Phe Arg Lys Tyr Phe Pro Val Thr Gly Lys 
            260                 265                 270         


Lys Gly Leu Ser Ser Gly Gly Asp Ser Glu Lys Leu Asn Ser Leu Ala 
        275                 280                 285             


Ser Glu Lys Asn Val Lys Tyr Tyr Tyr Ser Asp Lys Tyr Val Phe Gln 
    290                 295                 300                 


Gln Val Trp Arg Gln Ile Val Asn Gln Leu Thr Ala Gly Leu Ile Gln 
305                 310                 315                 320 


Tyr Gly Lys Leu Ser Tyr Tyr Phe His Asp Lys Glu Asn His Thr Trp 
                325                 330                 335     


Gln Glu Glu Lys Leu Asn Ser Glu Gly Met Gln Glu Ile Gln Val Arg 
            340                 345                 350         


Glu Thr Phe Lys Lys Gln Leu Phe Leu Ser Val Val Trp Ser Val Asn 
        355                 360                 365             


Lys Leu Asn Tyr Phe Phe Gln Tyr Gly Gly Glu Asn Pro Lys Met Leu 
    370                 375                 380                 


Tyr Gln Val Lys Tyr Asp Glu Asp Cys Ile Ala Gly Asp Ile Ile Glu 
385                 390                 395                 400 


Glu Leu Arg Lys Ala Asp Phe Ser Arg Phe Cys Tyr Asp Asp Pro Ile 
                405                 410                 415     


Lys Asn Asn Tyr Ile His Arg Phe Met His Gly Ile Lys Glu Glu Pro 
            420                 425                 430         


Glu Lys Phe Glu Leu Leu Phe Asp Lys Met Ser Val Ser Tyr Pro Leu 
        435                 440                 445             


Glu Glu Glu Asp Lys Asn Pro Glu Glu Ile Leu Lys Val Leu Gln Glu 
    450                 455                 460                 


Ile Asn Cys Ser Val Thr Asp Leu Arg His Ser Ile Ile His Tyr Gln 
465                 470                 475                 480 


Lys Asp Val Val Tyr Gln Glu Thr Gln Gly Pro Lys Tyr Pro Lys Ala 
                485                 490                 495     


Ser Glu Phe Leu Arg Arg Asp Ile Asp Asn Ile Glu Asn Cys Phe Leu 
            500                 505                 510         


Glu Gln Ile Arg Ser Met Ser Leu Ala Glu Tyr Tyr Pro Leu Asp Leu 
        515                 520                 525             


Leu Gln Lys Val Phe Lys Asp Cys Asn Leu Asn Phe Gln Leu Tyr Ala 
    530                 535                 540                 


Ser Gln Val Pro Met Val Pro Ser Phe Gln Lys Val Phe Gly Lys Gly 
545                 550                 555                 560 


Val Asn Leu Tyr Lys Ala Asp Gln Lys Ser Gly Ser Leu Lys Trp Tyr 
                565                 570                 575     


Met Glu Glu Arg Lys Asp Pro Glu Ala Lys Leu Ala Thr Leu Ala Tyr 
            580                 585                 590         


Arg Asn Phe Ile Gln Leu Ile Tyr Tyr His Gly Phe Leu Pro Ala Val 
        595                 600                 605             


Glu Lys Asn Asn Ala Leu Val Thr Asp Phe Ile Asn Glu Thr Val Glu 
    610                 615                 620                 


Trp Asn Gln Glu Arg Ser Leu Gln Ser Gln Arg Glu Asp Pro Glu Thr 
625                 630                 635                 640 


Lys Tyr Ile Asn Phe Ser Lys Tyr Arg Tyr Gln Gly Met Pro Glu Phe 
                645                 650                 655     


Gln Asn Lys Ser Leu Leu Glu Tyr Met Ser Glu Leu Gln Arg Asp Gln 
            660                 665                 670         


Ser Asn Lys Glu Lys Glu Asp Ser Lys Ala Gly Val Pro Glu Asp Lys 
        675                 680                 685             


Lys Lys Arg Tyr Tyr Thr Lys Phe Ile Gln Asp Ile Phe Ala Phe Ser 
    690                 695                 700                 


Phe Gly Ser Phe Leu Asn Ser Lys Leu Asn Glu Cys Arg Glu Asp Leu 
705                 710                 715                 720 


Leu Gln Pro Arg Tyr Gln Glu Ile Lys Thr Asn Glu Asp Arg Glu Gln 
                725                 730                 735     


Arg Leu Lys Lys Leu Leu Glu Asp Leu Glu Met Lys Thr Asn Ile Lys 
            740                 745                 750         


Asn Gly Ser Pro Thr Gln Leu Ala Met Tyr Pro Phe Leu Lys Leu Leu 
        755                 760                 765             


Asp Gln Arg Gly Leu Asn Gln Leu Leu His Gln Phe Ile Arg Cys Ser 
    770                 775                 780                 


Ala Ser Val Lys Ser Gly Phe Met Gln Asp Asp Lys Ala Leu Asn Leu 
785                 790                 795                 800 


Asn Arg Glu Ile Glu Glu Leu Ile Ala Leu Val Ala Phe Thr Lys Arg 
                805                 810                 815     


Pro Leu Met Asn Thr Glu Ala Tyr Ser Arg Ala Ile Glu Met Leu Ser 
            820                 825                 830         


Glu Thr Phe Ile Glu Gly Glu Ile Lys Asp Tyr Ala Asp Leu Tyr Tyr 
        835                 840                 845             


Gln Ser Asp Gln Glu His Ser Val Leu His Arg Asn Ile Ala Tyr Met 
    850                 855                 860                 


Gly Gly Thr Gly Val Ile Ala Leu Tyr Ser Asp Val Leu Arg Asp Cys 
865                 870                 875                 880 


Tyr Arg Val Lys Lys Thr Asp Tyr Val Glu Tyr Lys Lys Ala Asn Ser 
                885                 890                 895     


Lys Glu Asn Gly Arg Gln Phe Thr Arg Ile Gly Glu Asp Gln Lys Arg 
            900                 905                 910         


Leu Gln Asp Leu His Glu Ser Leu Ile Gly Arg Tyr Asn Ser Gly Gln 
        915                 920                 925             


Ile Gln Glu Tyr Lys Lys Leu Leu Arg Lys Thr His Glu Tyr Asn Val 
    930                 935                 940                 


Leu Lys Lys Arg Ile Thr Phe Glu Asn Met Tyr Glu Ile Tyr Gln Leu 
945                 950                 955                 960 


His Thr Glu Leu Leu Gly Arg Leu Ala Ser Phe Ala Glu Asp Trp Glu 
                965                 970                 975     


Arg Asp Met Leu Phe Leu Leu Thr Gly Leu Glu Ser Arg Gly Leu Ile 
            980                 985                 990         


Glu Asp Arg Val Glu Lys Ile Phe  Leu Lys Asp Lys Gly  Gly Val Val 
        995                 1000                 1005             


Ala Lys  Met Asn Lys Asn Leu  Lys Asp Asn Glu Lys  Leu Leu Lys 
    1010                 1015                 1020             


Ser Leu  Tyr Cys Arg Glu Asp  Gln Glu Ser Thr Asp  Phe Trp Lys 
    1025                 1030                 1035             


Thr Phe  His Val Arg Asn Ala  Val Ala His Phe Asn  His Phe Thr 
    1040                 1045                 1050             


Gln Lys  Ser Gln Ser Lys Gly  Gly Ser Val Val Tyr  Gln Arg Ser 
    1055                 1060                 1065             


Ile Glu  Glu Leu Ile Asn Arg  Ile Arg Gly Leu Leu  Ala Tyr Asp 
    1070                 1075                 1080             


Met Lys  Arg Gln Asn Ala Val  Thr Gln Ala Val Gln  Lys Ile Phe 
    1085                 1090                 1095             


Asp Lys  His Gln Met Ile Ile  Lys Phe Lys Pro Val  Thr Ile Asn 
    1100                 1105                 1110             


Ser Asp  Pro Glu Lys Trp Val  Gly Thr Trp Asn Ile  Glu Phe Gly 
    1115                 1120                 1125             


Ile Asp  Cys Ile Arg Ser Lys  Asn Ile Val His Phe  Lys Asn Leu 
    1130                 1135                 1140             


Ser Asp  Arg Ile Cys Leu Ile  Glu Ala His Asp Arg  Asn Thr Ile 
    1145                 1150                 1155             


Lys Ala  Ile Glu Lys Leu Met  Lys Phe Lys Tyr Asn  
    1160                 1165                 1170 


<210>  1166
<211>  1315
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1166

Met Ile Ile Ile Lys Lys Phe Gly Arg Ser Val Ile Thr Gln Asp Lys 
1               5                   10                  15      


Asn Thr Asp Asn Lys Arg Glu Arg Glu Leu Asp Thr Ser Ala Arg Ala 
            20                  25                  30          


Lys Ala Lys Ser Gln Asn Ser Gln Val Phe Pro Phe Leu Asn Lys Lys 
        35                  40                  45              


Glu Asp Phe Ile Asn Leu Trp Ile Ser Glu Phe Asp Lys Leu Ile Tyr 
    50                  55                  60                  


Lys Pro Lys Gly Asp Asp Lys Pro Thr Lys Glu Met Tyr Thr Leu Arg 
65                  70                  75                  80  


Glu Ala Ala Gly Lys Gly Phe Leu Asn Tyr Trp Asn Gln Met Pro Met 
                85                  90                  95      


Val Ser Lys Lys Asp Gly Ala Phe Ser Asp Met Trp Met Ser Lys Val 
            100                 105                 110         


His Pro Tyr Gly Arg Gly Ile Thr Glu Phe Ser Pro Pro Leu Gln Leu 
        115                 120                 125             


Glu Lys Leu Ile Asp Gln Gly Leu Leu Ser Ala Met Gly Gly Ser Glu 
    130                 135                 140                 


Pro Leu Lys Asn Cys His Trp Asn Arg Val Thr Ser Asn Val Phe Lys 
145                 150                 155                 160 


Gly Leu Lys Val Gln Leu Asp Ile Leu Glu Ala Gln Ala Lys Asn Thr 
                165                 170                 175     


Phe Val Ile Lys Asn Lys Thr Asn Ser Lys Arg Asn Arg Pro Ala Ser 
            180                 185                 190         


Gln Asn Ile Lys Glu Phe Leu Leu Thr Asp Glu Thr Ala Phe Ile Asn 
        195                 200                 205             


Leu Trp Ile Ser Glu Phe Asp Lys Leu Ile Leu Lys Pro Gln Gly His 
    210                 215                 220                 


Asn Lys Pro Thr Glu Lys Met Tyr Asn Leu Arg Gln Gln Ala Gly Val 
225                 230                 235                 240 


Ala Phe Leu Asn Tyr Trp Lys Lys Lys Pro Leu Ile Pro Trp Ala Asn 
                245                 250                 255     


Ser Glu Ser Phe Pro Asp Lys Trp Met Leu Lys Val His Pro Tyr Gly 
            260                 265                 270         


Asp Lys Thr Ser Asn Asn Arg Ser Glu Thr Leu Ile Lys Ser Lys Trp 
        275                 280                 285             


Gly Ser Val Met Arg Ala Lys Glu Cys Leu Ser Asp Asp Gln Trp Glu 
    290                 295                 300                 


Gln Val Ala Phe Asn Val Tyr Ser His Leu Tyr Gly Asn Gln Lys Thr 
305                 310                 315                 320 


Leu Asn Gly Lys Asn Lys Glu Ile Gly Leu Ile Ala Ala Arg Ala Asn 
                325                 330                 335     


Ser Ile Lys Gln Asn Val Pro Ser Tyr Thr Leu Asp Lys Asp Asn Asn 
            340                 345                 350         


Phe Leu Ser Asp Lys Lys Asp Lys Leu Arg Tyr Ile Ala Ala Leu Arg 
        355                 360                 365             


Gly Glu Gly Ile Lys Trp Glu Glu Val Lys Asp Arg Tyr Lys Trp Lys 
    370                 375                 380                 


Glu Leu Thr Gln Leu Ile Asn Ile Glu Glu Ile Asp Ser Thr Asp Ile 
385                 390                 395                 400 


Ala Lys Arg Lys Gln His Leu Ala Glu Cys Phe Tyr Thr His His Gly 
                405                 410                 415     


Arg Ile Phe Gly Asp Ile Gln Asn Ser Lys Ile Glu Asp Lys Asp Cys 
            420                 425                 430         


Phe Leu Tyr His Ser Leu Val Lys Glu Ile Leu Phe Glu Cys Ile Glu 
        435                 440                 445             


Lys Lys Gln Asp Phe Leu Asn Asp Thr Glu Val His Gln Arg Leu Ile 
    450                 455                 460                 


Tyr Lys Glu Asn Asn Arg Ile Met Ala Thr Ala Val Ser Ile Gly Lys 
465                 470                 475                 480 


Leu Ile His Tyr Gln Gly Gly Ile Glu Ala Ile Gly Asn Lys Glu Asp 
                485                 490                 495     


Leu Val Asn Ser Lys Phe Leu Thr Asp Ala Gly Leu Thr Glu Ile Lys 
            500                 505                 510         


Gln Asn Glu Ser Phe Val Arg Gln Trp Leu Glu Leu Ile Ala Ile Ala 
        515                 520                 525             


Asn Thr Thr Leu Ser Gln Leu Val Asp Pro Asp Gly Lys His Glu Asp 
    530                 535                 540                 


Ile Phe Ala Ala Thr Ser Phe Asp Asp Ala Leu Lys Gly Leu Asn Asn 
545                 550                 555                 560 


Ile Ser Asp Phe Asp Ser Lys Phe Lys Leu Leu Phe Gly Glu Asn His 
                565                 570                 575     


Arg Leu Tyr Asp Asp Asp Thr Glu Arg Gln Lys Leu Leu Arg Ile Ile 
            580                 585                 590         


Tyr Asp Thr Ile Ser Ala Leu Arg Asn Ala Ser Phe His Phe Lys Asn 
        595                 600                 605             


Ile Gln Gly Phe Asn Lys Ala Leu Glu Asp Asn Leu Ser Thr Lys Gly 
    610                 615                 620                 


Arg Arg Gln Lys Gly Val Val Asp Lys Ile Ile Glu Tyr Thr Lys Val 
625                 630                 635                 640 


His Gln Gln Lys Gln His Glu Leu Leu Ile Ala Asp Leu Lys Ala Ala 
                645                 650                 655     


Asn Val Glu Asp Tyr Leu Ser Gln Leu Gln Leu Asp Tyr Leu Phe Glu 
            660                 665                 670         


Val Val Cys Lys Gly Glu Arg Glu Leu Leu Asp Met Pro Lys Phe Ser 
        675                 680                 685             


Lys Leu Leu Leu Arg Ala Gly Glu Ile Gly Glu Lys Ile Ile Ser Pro 
    690                 695                 700                 


Val Asn Ala Thr Ala Met Glu His Pro Ala Tyr Gln Cys Cys Phe Ile 
705                 710                 715                 720 


Ser Leu Lys Met Leu Tyr Asp Gln Asp Phe Val Asn Trp Leu Lys Lys 
                725                 730                 735     


Gln Ser Asn Lys Asn Ile Ala Ser Trp Met Asp Ser Ala Lys Thr Arg 
            740                 745                 750         


Ala Thr Asn Ala Ala Lys Lys Ile Phe Arg Asn Gly Thr Asn Ile Ser 
        755                 760                 765             


Ser Lys Met Ala Arg Leu Arg Asn Ile Val Glu Asp Glu Thr Leu Val 
    770                 775                 780                 


Glu Tyr Phe Ser Phe Ile Thr Ala Glu Thr Ala Asn Glu Phe Gln Val 
785                 790                 795                 800 


Gln Gln Gln Lys Asn Arg Tyr Gln Ser Asn Ser Ala Ser Ala Lys Glu 
                805                 810                 815     


Gln Ser Asn Phe Val Glu Gln Phe Lys Gln Asp Phe Leu Ile Tyr Ala 
            820                 825                 830         


Phe Lys Gly Tyr Ile Gly Asp Ile Lys Phe Gly Lys Leu Asp Gln Gly 
        835                 840                 845             


Glu Lys Leu Leu Lys Cys Asn Ala Lys Gly Ser Leu Leu Pro Glu Asn 
    850                 855                 860                 


Asn Arg Ser Asp Thr Gly Ala Glu Asp Ile Glu Arg Pro Trp Leu Tyr 
865                 870                 875                 880 


Leu Val Leu His Leu Val Pro Ile Glu Val Val Asn Arg Ile Thr Leu 
                885                 890                 895     


Gln Ile Lys Lys His Ser Val Leu Thr Asn Ser Thr Leu Asp Asp Thr 
            900                 905                 910         


Arg Ala Ala Tyr Thr Asp Ile His Gln Ala Phe Ser Leu Tyr Leu Gly 
        915                 920                 925             


Val His Gly Ala Ile Leu Gly Leu Gln Ser Leu Ser Asn Glu Pro Glu 
    930                 935                 940                 


Leu Gln Val Phe Phe Glu Lys Glu Ser Asp Phe Asn Asn Leu Phe Thr 
945                 950                 955                 960 


Asp Asn Gly Glu Gly Leu Val Pro Val Lys Gly Leu Arg Asp Ile Leu 
                965                 970                 975     


Arg Phe Gly Asn Leu Glu Gln Leu Lys Lys Met Phe Ser Asp Lys Lys 
            980                 985                 990         


Val Ala Ser Asp Asp Ile Thr Asn  Leu Lys Glu Tyr Leu  Glu Ala Thr 
        995                 1000                 1005             


Gly Gly  Lys Ser Lys Ile Ala  Arg Ala Gln Glu Lys  Arg Ile Glu 
    1010                 1015                 1020             


Leu His  Lys Thr Leu Thr Glu  Leu Pro Lys Arg Leu  Thr Lys Pro 
    1025                 1030                 1035             


Arg Val  Lys Gln Thr Gly Ile  Asp Thr Tyr Glu Lys  Asn Asn Asn 
    1040                 1045                 1050             


Ile Ser  Ile Ser Gly Ser Ile  Ser Glu Tyr Arg Lys  Asp Leu Lys 
    1055                 1060                 1065             


Cys Ile  Val Ser Tyr Arg Glu  Leu Lys Asn Lys Ile  Tyr Leu Tyr 
    1070                 1075                 1080             


Asn Val  Lys Gln Ala His Gln  Leu Ile Met Ala Thr  Gln Ala Arg 
    1085                 1090                 1095             


Leu Leu  Gly Tyr Ser Gln Ile  Arg Glu Arg Asp Leu  Tyr Phe Val 
    1100                 1105                 1110             


Leu Leu  Thr Gln Leu Met Leu  Arg Gly Val Thr Leu  Glu Lys Glu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Asp Lys Asp  Lys Leu Asn Ala Leu  Asp Thr Asp 
    1130                 1135                 1140             


Thr Val  Leu Asp Glu Glu Glu  Lys Lys Lys Leu Glu  Lys Gln Ile 
    1145                 1150                 1155             


Lys Pro  Glu Arg Ser Leu Lys  Asp Leu Val Glu Lys  Gly Leu Ile 
    1160                 1165                 1170             


Phe Leu  Ala Leu Asp Gln Leu  Ser Ser Ser Asp Lys  Asp Leu Lys 
    1175                 1180                 1185             


Ala Ile  His Ser Glu Ile Glu  Asp Met Phe Val Gly  Val Ser Pro 
    1190                 1195                 1200             


Asp Ser  Asp Asn Arg Asn Leu  Arg Asn Arg Leu Ala  His Phe Lys 
    1205                 1210                 1215             


Asp Leu  Gly Asn Lys Asn Leu  Ile Asn Ile Thr Ser  Gln Ile Asn 
    1220                 1225                 1230             


Glu Val  Arg Lys Met Met Ser  Tyr Asp Arg Lys Leu  Lys Asn Ala 
    1235                 1240                 1245             


Val Ser  Lys Ser Met Ile Asp  Leu Phe Glu Arg Tyr  Asn Leu Ile 
    1250                 1255                 1260             


Leu Ser  Phe Lys Val Gln Ser  His Lys Leu Gln Leu  Lys Asn Leu 
    1265                 1270                 1275             


Lys Ser  Lys Gln Ile Thr His  Leu Asn Asn Lys Gly  Ile Thr Glu 
    1280                 1285                 1290             


Asn Leu  Leu Ser Asp Asp Tyr  Val Ser Val Ile Lys  Arg Leu Leu 
    1295                 1300                 1305             


Leu Thr  Glu Gln Asn Pro Glu  
    1310                 1315 


<210>  1167
<211>  1298
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1167

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Thr Glu Asn Lys Asn Glu Glu Gln Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Lys Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Arg Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Leu Lys Lys Asn Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Ser Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Cys Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Thr Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Ile Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Gln Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Lys 
                405                 410                 415     


Arg Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Ile Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Ala Leu Glu Gly Glu Ser 
    450                 455                 460                 


Val Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Lys Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Glu Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Ala Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Arg Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Lys Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Lys Gly Asp Lys Glu Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Glu Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Ser Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Lys Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Ala Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Val Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Glu Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Met Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg 
    1295             


<210>  1168
<211>  1104
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1168

Met Arg Ile Val Lys Pro His Gly Thr Ser Glu Thr His Phe Asp Lys 
1               5                   10                  15      


Glu Gly Arg Ile Arg Arg Tyr Val His Ser Asp Ser Phe Pro Cys Glu 
            20                  25                  30          


Pro Leu Glu Pro Lys Glu Phe Ala Thr Arg His Pro Lys Leu Val Ile 
        35                  40                  45              


Ala Gln Trp Val Ser Cys Ile Asp Lys Val Ile Thr Arg Pro His Gly 
    50                  55                  60                  


Asp Gly Leu Pro Ser Glu Thr Gln Trp Ser Leu Arg Asn Gly Leu Gly 
65                  70                  75                  80  


Lys Ala Ala Trp Asp Leu Ile Val Glu Arg Gly Leu Leu Asp Ala Pro 
                85                  90                  95      


Glu Lys Arg Leu Lys Arg Phe Glu Arg Gln Trp Trp Ala Arg Ile His 
            100                 105                 110         


Pro Tyr Gly Asn Glu Thr Asp Ala Asn Thr Pro Arg Asn Pro Tyr Gly 
        115                 120                 125             


His Trp Tyr Arg Ser Leu Ala Gly Gly Val Asp Ile Ala Glu Phe Asp 
    130                 135                 140                 


Pro Ala Thr Val Ala Asn Met Ile Tyr Ala His Leu Tyr Glu Asn Ala 
145                 150                 155                 160 


Ser Arg Thr His Pro Glu His Gly Pro Arg Arg Ser Gly Leu Ile Pro 
                165                 170                 175     


Glu Arg Ser Glu Ser Ile Ala Lys Ser Val Pro Ala Arg Thr Ala Pro 
            180                 185                 190         


Gly Gly Gly Arg Leu Ser Pro Pro Trp Asp Ala Ser Asp Gly Ala Ile 
        195                 200                 205             


Tyr Leu Glu Ala Gly Asp Val Ala Ala Thr Met Leu Glu Arg Leu Glu 
    210                 215                 220                 


Lys His Phe Gly Glu Arg His Ala Lys Leu Arg Arg Ile Cys Ala Ala 
225                 230                 235                 240 


Thr Leu Ala Glu His Leu Thr Arg Leu Arg Arg Glu Val Leu His Ile 
                245                 250                 255     


Ser Asp Gly Asp Arg Leu Pro Glu Ser Leu Tyr Gln Leu His Glu Gln 
            260                 265                 270         


Val Arg Arg Ser Tyr Ser Asp Ile Leu Lys Gly Asp Gln Arg Tyr Leu 
        275                 280                 285             


Ser Lys Lys Leu Pro Ser Ser Gly Asp Gln Leu Val Ser Leu Val Glu 
    290                 295                 300                 


Ser Lys Arg Leu Asn Arg Glu Val Ala Ala Leu Ile Arg Leu Gly Arg 
305                 310                 315                 320 


Val Ile His Tyr Glu Ser Thr Ala Glu Asn Gly Pro Ser His Thr Ser 
                325                 330                 335     


Asn Val Leu Asp His Trp Pro Ser Gln Thr Asp Ser Ser Arg Phe Trp 
            340                 345                 350         


Leu Ser Ala Gly Gln Thr Glu Ile Lys Arg Asn Glu Ala Phe Val Arg 
        355                 360                 365             


Ile Trp Arg Gly Ile Leu Ala Arg Ala Ala Arg Thr Ala Thr Asp Trp 
    370                 375                 380                 


Ala Asp Pro Glu Arg Ala Ile Pro Arg Asp Val Leu Gly Ala Lys Gln 
385                 390                 395                 400 


Leu Ser Glu Ala Val Thr Asn Ile Thr Asp Thr Ala Phe Asp Arg Lys 
                405                 410                 415     


Ala Lys Leu Leu Phe Gly Asn Arg Ser Asp Leu Leu Thr Ser Leu Pro 
            420                 425                 430         


Leu Glu Arg Lys Arg Gln Val Leu Asp Leu Ala Leu Arg Gly Leu Gly 
        435                 440                 445             


Gln Leu Arg Asn Asn Ala Phe His Phe Val Gly Leu Glu Ala Phe Leu 
    450                 455                 460                 


Ala Ser Leu Arg Gly Leu Asp Gly Ile Ala Asp Ala Asp Thr Arg Thr 
465                 470                 475                 480 


Val Leu Asp His Ile Trp Arg Asp Asp Thr Lys Asp Arg Asn Thr Arg 
                485                 490                 495     


Leu Val Gln Thr Ile Arg Ala Ser Asn Ala Pro Ala Tyr Phe Ser Arg 
            500                 505                 510         


Gln Glu Met Glu Gly Phe Val Ser Ser Ile Ala Arg Thr Pro Ala Val 
        515                 520                 525             


Phe Leu Glu Leu Pro Ala Phe Gly Arg Ile Leu Arg Arg Ala Ser Val 
    530                 535                 540                 


Ala Trp Thr Ile Asp Arg Tyr Arg Leu Thr Leu Pro Ala Pro Lys Ala 
545                 550                 555                 560 


Val Gly Glu Pro Val Ala Ala Glu Cys Gln Arg Val Cys Leu Gly Leu 
                565                 570                 575     


Ile Tyr Asp Arg Ala Phe Gly Asp Trp Leu Gln Val Leu Glu Thr Glu 
            580                 585                 590         


Arg Leu Arg Asp Cys Val Asp Arg Ala Val Thr Arg Ala Ser Val Glu 
        595                 600                 605             


Ala Arg Arg Val Thr Arg Asp Asp Thr Val Asn Ala Arg Thr Ile Gly 
    610                 615                 620                 


Lys Phe Lys Ile Thr Gln Gly Asp Thr Leu Glu Ser Phe Phe Ser Arg 
625                 630                 635                 640 


Leu Thr Ala Ala Val Thr Arg Glu Leu Arg Gln Thr Asp Ala Arg Lys 
                645                 650                 655     


Gln Thr Lys Arg Ala Ala Ser Lys His Leu Asp Asp Leu Arg Cys Asp 
            660                 665                 670         


Val Val Ala Gln Leu Phe Glu Ile Tyr Leu Lys Glu Ala Asp Leu Gly 
        675                 680                 685             


Trp Leu Leu Ser Gly Phe Gln Thr Arg Lys Pro Thr Gly Ala Ser Lys 
    690                 695                 700                 


Thr Asp Ala Ala Phe Cys Pro Pro Pro Ser Ser Ala Gln Thr Phe Gln 
705                 710                 715                 720 


Ala Trp Glu Pro Ile Leu Tyr Phe Ile Leu His Leu Val Pro Val Asp 
                725                 730                 735     


Thr Thr Thr Arg Leu Ala His Gln Val Gly Arg Phe Arg Asp Gly Gly 
            740                 745                 750         


Gln Ile Asp Thr Gly Leu Ile Glu Gly Leu Gln Arg Thr Leu Asp Leu 
        755                 760                 765             


Tyr Arg Val Met His Asp Ala Lys Phe Ala Gly Ala Ala Ser Gly Leu 
    770                 775                 780                 


Arg Pro Asp Glu Met Arg Ser Ile Leu Leu Lys Thr Gly Leu Tyr Ser 
785                 790                 795                 800 


Gly Ala Thr Glu Gly Thr Glu Leu Ala Phe Glu Thr Arg Gly Leu Arg 
                805                 810                 815     


Glu Phe Phe Arg Phe Gly Asp His His Leu Phe Thr Thr Asp Phe Ala 
            820                 825                 830         


Gln Asn Pro Val Thr Arg Asp Gln Phe His Glu Ile Lys Ser Leu Arg 
        835                 840                 845             


Ala Asp Leu Ala Leu Ala Gln Asp Arg Arg Ser Ala Leu His Ala Glu 
    850                 855                 860                 


Trp Val Ser Asn Gly Lys Ala Leu Ser Gly Ala Lys His Asp Glu Tyr 
865                 870                 875                 880 


Arg Ala Leu Leu Asn Arg Ile Glu Arg Gly Arg His Leu Ser Asp His 
                885                 890                 895     


Ala Glu Leu Arg Asp His Leu Arg Leu His Gly Ile Leu Ile Asp Val 
            900                 905                 910         


Leu Ala Arg Leu Leu Asp Phe Ala Gly Gln Trp Glu Arg Asp Leu Tyr 
        915                 920                 925             


Phe Thr Thr Leu Ala Leu Ile His Leu Ala Gly Thr Thr Pro Gln Asp 
    930                 935                 940                 


Ala Phe Asp Asp Arg Arg Gly Trp His Ala Val Arg Thr Gly Gln Ile 
945                 950                 955                 960 


Leu Ala Ala Leu Arg Ser Thr Arg Asp Thr Pro Glu Met Gln Asp Ile 
                965                 970                 975     


Leu Ala Lys Leu Ala Met Val Phe Asn Ile Asp Met Pro Gly Val Arg 
            980                 985                 990         


Gly Ala Asn Val Arg Thr Arg Asn  Asp Leu Ala His Phe  Asn Cys Leu 
        995                 1000                 1005             


His Thr  Pro Ala Ala Ser Ile  Asp Leu Thr Ala Leu  Ile Asn Arg 
    1010                 1015                 1020             


Thr Arg  Ala Leu Met His Tyr  Asp Arg Lys Gln Glu  Asn Ala Val 
    1025                 1030                 1035             


Ser Lys  Ser Val Ile Glu Leu  Leu Asp Arg His Lys  Leu Val Leu 
    1040                 1045                 1050             


Ser Trp  Thr Phe Ser Gly Gly  Gln Leu Gly Lys Ser  Thr Val Arg 
    1055                 1060                 1065             


Pro Lys  Val Ile Arg His Leu  Glu Gln Pro Glu Val  Lys Glu Cys 
    1070                 1075                 1080             


Leu Val  Ser Thr Ala Phe Ser  Ala Ala Val Gly Arg  Leu Phe Gly 
    1085                 1090                 1095             


Ala Thr  Glu Lys Asp Gly 
    1100                 


<210>  1169
<211>  1032
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1169

Met Lys Val Thr Lys Ala Glu Lys Leu Arg Val Ala Val Ser Arg Lys 
1               5                   10                  15      


Leu Asn Asn Glu Asp Lys Arg Ala Val Leu Tyr Lys Thr Pro Asn Pro 
            20                  25                  30          


Gly Gln Thr Cys Gly Thr Val Lys Lys Gln Leu Ala Asn Arg Val Glu 
        35                  40                  45              


Arg Ala Asn Lys Leu Tyr Gly Val Phe Phe Arg Ser Asp Val Pro Glu 
    50                  55                  60                  


Thr Leu Gln Tyr His Phe Glu Glu Leu Val Thr Tyr Ala Ala Gln Ser 
65                  70                  75                  80  


Thr Ser Pro Asn Glu Phe Arg Gln Lys Ala Ser Gln Tyr Arg Glu Cys 
                85                  90                  95      


Glu Lys Lys Asp Lys Phe Gly Lys Met Arg Lys Tyr Pro Ile Phe Arg 
            100                 105                 110         


Cys Ser Tyr Ala Pro Ser Gly Lys Asn Met Lys Lys Val Met Glu Leu 
        115                 120                 125             


Tyr Val Arg Glu Arg Met Lys Asp Glu Trp Gln Ser Gln Ala Tyr Arg 
    130                 135                 140                 


Thr Ala Ala Ile Glu Ile Leu Leu Cys Ile Cys Asn Lys Asp Phe Ser 
145                 150                 155                 160 


Lys Gln Leu Ser Arg Val Asp Ala Arg Ile Phe Ala Asp Phe Tyr Asn 
                165                 170                 175     


Ala Ser Lys Ala Cys Pro Gln Pro Tyr Ile Gly Lys Ser Thr Gly Val 
            180                 185                 190         


Leu Glu Ala Ala Phe Thr Ser Val Met Lys Gln Met Ser Leu His Ala 
        195                 200                 205             


Lys Ala Asn Ala Ser Asn Lys Ile Trp Trp Leu Gln Asn Gln Leu Arg 
    210                 215                 220                 


Thr Ile Glu Leu Asn Lys Lys Ile Val Lys Ile Ser Asp Phe Lys Tyr 
225                 230                 235                 240 


Glu Tyr Ala Thr Glu Asp Arg Met Arg Ala Ile Leu Val Arg Met Arg 
                245                 250                 255     


Lys Ser Leu Lys Arg Gly Thr Asn Gly Asp Ile Ala Val Ala Leu Leu 
            260                 265                 270         


Gln Gly Ile Ala Gln Met Asn Gly Lys Thr Leu Ser Gly Val Leu Glu 
        275                 280                 285             


Glu Leu Ser Ala Asn Ser Glu Thr Lys Glu Gln Leu Ile Lys Phe Leu 
    290                 295                 300                 


Lys Ala Val His Glu Asp Tyr His Lys Thr Pro Ile Leu Lys Ala Ile 
305                 310                 315                 320 


Arg Asn Gln Asp Val Lys Val Gln Val His Glu Val Asp Pro Val Ser 
                325                 330                 335     


Pro Glu Gly Arg Ala Leu Asp Leu Ala Ser Ile Asn Val Ser Lys Gly 
            340                 345                 350         


Asn Glu Arg Lys Lys Tyr Lys Val Ala Leu Thr Gln Thr Leu Gly Asn 
        355                 360                 365             


Tyr Ala Lys Ser Pro Lys Asp Ala Thr Gln Thr Leu Lys Ala Ile Lys 
    370                 375                 380                 


Gly Val Leu Leu Asp Tyr Phe Met Trp Leu Asp Ser Asp Val Lys Ala 
385                 390                 395                 400 


Glu Phe Leu Glu Asp Asn Asn Leu Trp Lys Ile Pro Asn Arg Thr Glu 
                405                 410                 415     


Glu Tyr Phe Asp Asn Asn Phe Val Pro Ile Asp Asp Lys Lys Asp Asp 
            420                 425                 430         


Lys Ile Glu Ala Ile Glu Asp Phe Ala Ser Ile Trp Arg Gln Glu Arg 
        435                 440                 445             


Val Lys Asn Ser Arg Ile Lys Ala Arg Met Asn Tyr Val Asn Cys Gly 
    450                 455                 460                 


Lys Tyr Gln Gln Leu Ile Lys Gln Glu Thr Asp Asp Phe Arg Ile Cys 
465                 470                 475                 480 


Trp Ile Ser Tyr Ala Lys Asp Phe Val Glu Lys Asn Tyr Val Ser Lys 
                485                 490                 495     


Asn Arg Gln Phe Thr Gln Gly Asp Cys Phe Ser Thr Lys Met Leu Leu 
            500                 505                 510         


Glu Cys Trp Lys Glu Ile Ile Arg Phe Ile Cys Gly Lys Tyr Ile Asp 
        515                 520                 525             


Ile Gly Lys Ala Val Tyr His Phe Ala Met Pro Glu Thr Met Asn Ala 
    530                 535                 540                 


Arg Asp Ser Leu Ala Tyr Gly Val Leu Gly Glu Lys Tyr Lys Glu Gly 
545                 550                 555                 560 


Ile Ser Ser Phe Asp Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln 
                565                 570                 575     


Arg Asp Ile Ala Lys Ala Ala Val Ala Ala Ile His Ala Phe Ser Gly 
            580                 585                 590         


Ser Val Ile Asp Asp Lys Lys Pro Val Glu Asp Ile Leu Phe Ile Lys 
        595                 600                 605             


Asp Glu Glu Leu Gln Glu His Ala Lys Ala Asp Asp Val Ile Val Lys 
    610                 615                 620                 


Gln Ile Leu Arg Phe Tyr Gly Gly Phe Ser Ser Val Glu Gly Arg Glu 
625                 630                 635                 640 


Lys Leu Glu Gly Met Ala Leu Ala Lys Glu Val Leu Ser Gln Leu Lys 
                645                 650                 655     


Ala Ile Arg Asn Glu Asn Phe His Phe Thr Gln Gly Lys Arg Lys Asn 
            660                 665                 670         


Val Glu Glu Asn Ile Pro Leu Thr Lys Ala Leu Trp Glu Asn Glu Glu 
        675                 680                 685             


Lys Val Tyr Arg Gln Thr Val Lys Glu Thr Tyr Tyr Ser Asn Asn Val 
    690                 695                 700                 


Ser Met Phe Tyr Ser Gln Glu Val Ile Gln Lys Leu Val Ala Glu Leu 
705                 710                 715                 720 


Tyr Gln Asn Asn Asn Val Ala Glu Ala Gln Ile Pro Ala Phe Arg Thr 
                725                 730                 735     


Ile Trp Lys Arg Lys Asp Leu Pro Glu Tyr Ile Gly Ser Leu Asn Ile 
            740                 745                 750         


Ser Trp Asp Lys Thr Glu Pro Lys Gln Val Ile Tyr Glu Gly Ala Leu 
        755                 760                 765             


Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Lys Ser Gly 
    770                 775                 780                 


Glu Ala Lys Lys Leu Phe Phe Asp Ala Val Met Asp Asn Ala Thr Glu 
785                 790                 795                 800 


Met Glu Lys Ser Ser Asn Ala Asp Ser Arg Asn Gln Glu Lys Lys Ala 
                805                 810                 815     


Leu Ala Asn Ala Gly Lys Asn Phe Arg Asp Tyr Val Asn Gly Leu Asn 
            820                 825                 830         


Ala Ser Thr Leu Gly Glu Val Cys Gln Phe Ile Gln Asn Glu Tyr Asn 
        835                 840                 845             


Gln Gln Asn Arg Gly Lys Gln Glu Gln Glu Ile Tyr Lys His Phe Lys 
    850                 855                 860                 


Met Leu Leu Pro Ile Cys Met Arg Lys Ala Phe Gln Arg Tyr Ile Asp 
865                 870                 875                 880 


Glu Lys His Ser Phe Ile Lys Lys Pro Gly Glu Leu Pro Gln Thr Thr 
                885                 890                 895     


Glu Asp Tyr Leu Glu Asn Val Lys Val Ala Cys Pro Glu Lys Lys Ile 
            900                 905                 910         


Lys Leu Gly Arg Trp Phe Thr Phe Ala His Phe Ile His Pro Arg Glu 
        915                 920                 925             


Leu Asn Phe Leu Ile Gly Asp Phe Lys Asn Tyr Ile Gln Tyr Arg Glu 
    930                 935                 940                 


Asp Val Leu Arg Arg Ser Glu His Ala Gly Gln Phe Ser Asp Thr Thr 
945                 950                 955                 960 


Glu Arg Asp Gly Glu Lys Ala Val Val Asp His Ala Val Gln Lys Ala 
                965                 970                 975     


Lys Asp Ile Leu Gly Val Leu Glu Phe Val Arg His Ile Ser Gly Arg 
            980                 985                 990         


Val Ser Asn Glu Phe Thr Asp Tyr  Tyr Ala Asp Arg Ala  Glu Tyr Asp 
        995                 1000                 1005             


Glu Tyr  Met Ala Lys Tyr Phe  Glu Pro Asp Val Gln  Ile Glu Gln 
    1010                 1015                 1020             


Tyr Asp  Leu Tyr Gly Asp Ala  Lys Asn 
    1025                 1030         


<210>  1170
<211>  1298
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1170

Met Thr Arg Ala Ala Leu Asp Gln Glu Val Ile Met Arg Ile Gly Lys 
1               5                   10                  15      


Val Gln Gly Arg Thr Phe Thr Gly Phe Asp Asn Ala Arg Gly Lys Thr 
            20                  25                  30          


Leu Arg Arg Arg Leu Leu Thr Arg Pro Asp Asn Glu Ala Arg Ser Leu 
        35                  40                  45              


Ser Glu His Leu Ala His Asp Pro Lys Ala Leu Ile Gly Gln Ala Ile 
    50                  55                  60                  


Ser Arg Ile Asp Thr Ile Tyr Gln Lys Pro Lys Thr Gly Lys Pro Thr 
65                  70                  75                  80  


Pro Glu Gln Phe Gly His Arg Asp Thr Leu Gly Trp Ala Tyr Trp Lys 
                85                  90                  95      


Leu Leu Val Ala Ser Tyr Pro Glu Val Glu Gly His Arg Asp Leu Phe 
            100                 105                 110         


Val Arg Arg Leu His Pro Tyr Gly Asp Thr Pro Pro Lys Ser His Gly 
        115                 120                 125             


Gln Lys Glu Gly Glu His Gln Lys Gly Gly Lys Pro Gln Leu Glu Gly 
    130                 135                 140                 


Arg Trp His Gly Val Met Ala Gln His Gly Lys Asn Pro Asp Gln Ile 
145                 150                 155                 160 


Ala Ala Arg Leu Phe Asp His Leu His Asn Ser Glu Leu Arg Phe Gly 
                165                 170                 175     


Gly Thr Ala Ser Gly Glu Pro Arg Thr Arg Pro Gly Lys Glu Ala Thr 
            180                 185                 190         


Pro Thr Gly Leu Ile Gly Ala Arg Ala Lys Thr Ile Glu His Ser Val 
        195                 200                 205             


Leu Pro Arg Asp Ala Lys Arg Phe Val Ala Glu Trp Arg Gly Glu Asp 
    210                 215                 220                 


Gln Glu Arg Tyr Ala Gly Ala Arg Asp Ile Ala Ala Ala Ile Ser Ala 
225                 230                 235                 240 


Gly Leu Asn Asp Lys Asp Gln Lys Ser Gly Ser Gly Arg Lys Ser Ala 
                245                 250                 255     


Val Ile Gly Lys Leu Leu Ser Asp His Leu Glu Thr Leu Thr Gly Asn 
            260                 265                 270         


Arg Lys Cys Arg Phe Asp Pro Lys Ser Thr Ala Glu Thr Leu Glu Leu 
        275                 280                 285             


Arg Asp Gly Glu Ser Val Asp Asp Arg Arg Arg Ile Leu Glu Leu His 
    290                 295                 300                 


Ala Glu Val Lys Ala Thr Tyr Lys Arg Met Ala Ala Trp Lys Pro Ala 
305                 310                 315                 320 


Lys Leu Pro Arg Asn Ser Asp Glu Leu Phe Arg Leu Val Arg Gln Gln 
                325                 330                 335     


Ala Asp Asn Arg Ile Leu Asn His Leu Val Arg Val Gly Arg Ile Ser 
            340                 345                 350         


Val Tyr Ser Glu Gln Ser Asp Ala Leu Ser Glu Ser Gln Phe Trp Thr 
        355                 360                 365             


Ser Gly Gly Gln Thr Gln Ile Lys Glu Ser Glu Val Phe Ala Arg Leu 
    370                 375                 380                 


Trp Ile Gly Ala Ile Ser Arg Ala Ser Tyr Ser Met Lys Ala Trp Leu 
385                 390                 395                 400 


Glu Pro Glu Gly Thr Val Phe Asn Pro Ser Ile Asn Asp Phe Asp Val 
                405                 410                 415     


Thr Ser Ser His Asn Thr Asn Arg Ile Leu Glu Asp Ser Gly Arg Leu 
            420                 425                 430         


Ser Asn Ala Met Ala Arg Arg Ala Ile Tyr Phe Gly Glu Thr Pro Glu 
        435                 440                 445             


Phe Asp Ala Leu Gly Glu Glu Asp Gln Arg Val Leu Val Lys Lys Cys 
    450                 455                 460                 


Leu Asp Ala Leu Ser Ala Cys Arg Asn Arg Thr Phe His His Gly Gln 
465                 470                 475                 480 


Arg Ala Lys Phe Leu Lys Glu Val Arg Lys Gly Leu Lys Glu Lys Glu 
                485                 490                 495     


Ala Asp Ser Ala Gly Pro Ala Ala Trp Glu Gly Ile Arg Glu Val Ile 
            500                 505                 510         


Gln Ala Asp Ala Arg Asn Leu Gly Ala Arg Leu Leu Gln Asp Leu Thr 
        515                 520                 525             


Gly Ala Lys Val His Ser Phe Ala Thr Asp Pro Glu Phe Arg His Leu 
    530                 535                 540                 


Tyr Glu Ser Val Ala Ala Thr Leu Thr Ala Gly Gly Glu Leu Glu Ala 
545                 550                 555                 560 


Ala Leu Pro Arg Leu Lys Asn Val Leu Lys Arg Ala Glu Gly Val Arg 
                565                 570                 575     


Cys Tyr Leu Asp Thr Pro Ser Gln Arg Arg Glu Gly Asp Glu Ser Leu 
            580                 585                 590         


Ile Ala Arg Leu Pro Val Ala Pro Val Pro Arg Glu Leu Asp Asp Ala 
        595                 600                 605             


Ala Thr Lys Ala Arg His Ser Ala Leu Leu Arg Leu Tyr Asp Gly Pro 
    610                 615                 620                 


Phe Arg Pro Trp Ala Thr Glu Leu Arg Gly Glu Arg Leu Ser Asp Tyr 
625                 630                 635                 640 


Ala Ala Arg Ala Lys Arg Leu Ala Thr Arg Leu Ala Lys Ser Thr Asn 
                645                 650                 655     


Thr Ala Ser Pro Tyr Pro Asp Ser Val Glu Gly Arg Ser Val Arg Leu 
            660                 665                 670         


Arg Asp Pro Ile Thr Ala Asp Thr Ala Pro Glu Thr Leu Lys Thr Tyr 
        675                 680                 685             


Leu Ser Ala Leu Thr Ala Glu Thr Ala Thr Glu Phe Arg Val Gln Lys 
    690                 695                 700                 


Gly Tyr Glu Ser Asp Gly Glu Lys Ala Lys Glu Gln Ala Glu Phe Ile 
705                 710                 715                 720 


Glu Asp Phe Arg Arg Asp Met Ile Ala Leu Ala Phe Gln Asp Phe Ile 
                725                 730                 735     


Arg Asp His Gly Phe Ala Trp Leu Leu Asp Ile Ala Ser Lys Ala Glu 
            740                 745                 750         


Pro Ser Asn Asp Ala Pro Asn Leu Pro Asp Pro Val Asp Thr Gly Lys 
        755                 760                 765             


Asp Thr Val Phe Glu Asp Trp Gln Ala Leu Leu Tyr Leu Phe Leu His 
    770                 775                 780                 


Phe Val Pro Ala Asp Asp Val Ser Gln Leu Leu His Gln Leu Arg Lys 
785                 790                 795                 800 


Trp Asp Ala Leu Gln Asp Lys Tyr Glu Leu Ala Glu Pro Gly Glu Thr 
                805                 810                 815     


Leu Gly Gln Thr Lys Ala Asp Thr Arg Lys Ile Val Gly Gln Phe Arg 
            820                 825                 830         


Asp Cys Leu Thr Leu Phe Leu Lys Thr Gly Asp Ala Arg Phe Asp Gly 
        835                 840                 845             


Glu Gly Val Glu Leu Pro Leu Ser Asp Phe Gln Glu Leu Phe Glu Ser 
    850                 855                 860                 


Pro Ala Thr Phe Lys Glu Leu Phe Leu Ala Glu Pro Ala Glu Asn Asp 
865                 870                 875                 880 


Ala Ser Glu Thr Asp Asp Gln Asp Ala Pro Gly Glu Lys His Arg Val 
                885                 890                 895     


Thr Arg Thr Arg Arg Gly Leu Arg Gln Ile Leu Arg Tyr Asn His Met 
            900                 905                 910         


Pro Val Leu Arg Asp Leu Phe Leu Ala His Lys Val Thr Asp Ala Glu 
        915                 920                 925             


Val Asp Gly Leu Gln Ala Leu Glu Val Asp Asp Pro Gln Thr Gly Glu 
    930                 935                 940                 


Ser Gln Ile Gly Ala Ala Gln Arg Ile Arg Thr Glu Ile His His His 
945                 950                 955                 960 


Thr Ser Asn Asp Lys Gln Ile Ser Glu Ala Lys Val Glu Glu Tyr Arg 
                965                 970                 975     


Arg Ala Leu Ser Thr Ile Glu Arg His Arg Phe Leu Val Gly Arg Val 
            980                 985                 990         


Tyr Leu Gly Asp His Ile Arg Val  His Lys Leu Met Met  Asp Val Met 
        995                 1000                 1005             


Gly Arg  Leu Val Asp Phe Ala  Gly Ala Trp Glu Arg  Glu Ala Ala 
    1010                 1015                 1020             


Asp Gly  Asp Arg Lys Gly Phe  Ile Ser Arg Ala Ile  Ala Leu Pro 
    1025                 1030                 1035             


Glu Val  Ala Glu Gly Tyr Ala  Ala Asp Arg Leu Lys  Thr Val Ala 
    1040                 1045                 1050             


Arg Arg  Val Leu Asp Asp Gly  Glu Ala Arg Arg Ile  Arg Asn Asp 
    1055                 1060                 1065             


Leu Gly  His Phe Asn Asp Leu  Ala Pro Thr Ser Gly  Pro Ala Asn 
    1070                 1075                 1080             


Leu Thr  Phe Val Val Asn Arg  Ala Arg Arg Met Met  Arg His Asp 
    1085                 1090                 1095             


Arg Lys  Arg Lys Asn Ala Val  Thr Lys Ser Val Ile  Glu Ile Leu 
    1100                 1105                 1110             


Asn Arg  Gln Gly Leu Gly Ile  Glu Trp Thr Met Arg  Asn His Glu 
    1115                 1120                 1125             


Leu Cys  Glu Ala Lys Leu Trp  Gln Asn Pro Val Lys  His Leu Gly 
    1130                 1135                 1140             


Phe Ala  Thr Leu Glu Gly Arg  Gly Lys Lys Trp Arg  Arg Pro Phe 
    1145                 1150                 1155             


Glu Ala  Arg Tyr Gly Asp Ala  Tyr Met Ala Met Val  Ala Gln Leu 
    1160                 1165                 1170             


Phe Asp  Gly Thr Val Thr Ser  Pro Pro Ala Lys Gly  Pro Pro Gln 
    1175                 1180                 1185             


Ser Gly  Lys Ser Gly Gly Lys  Pro Gly Lys Gly Ala  Glu Gly Gly 
    1190                 1195                 1200             


Ala Lys  Glu Lys Ser Arg Ser  Pro Thr Arg Met Glu  Glu Gly Gly 
    1205                 1210                 1215             


Val Tyr  Glu Gly Arg Val Ala  Lys Ala Lys Ser Asp  Lys Gly Phe 
    1220                 1225                 1230             


Gly Phe  Leu Leu Val Glu Gly  Ala Gln Glu Glu Ile  Phe Leu His 
    1235                 1240                 1245             


Ile Tyr  Gly Ile Ser Gly Asn  Arg Pro Ala Arg Ile  Glu Asn Gly 
    1250                 1255                 1260             


Gln Arg  Tyr Arg Phe Thr Leu  Gly Ile Asp Arg Asp  Arg Glu Arg 
    1265                 1270                 1275             


Arg Lys  Glu Arg Ala Trp Val  Ala Arg Glu Ala Val  Arg Ile Asp 
    1280                 1285                 1290             


Glu Asn  Arg Ser Lys 
    1295             


<210>  1171
<211>  1025
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1171

Met Leu Ser Phe Leu Ser Gly Lys Tyr Ile Ala Thr Gly Lys Ala Val 
1               5                   10                  15      


Trp His Phe Ala Met Lys Glu Gly Ile Glu Asp Glu Thr Lys Asp Leu 
            20                  25                  30          


Asn Leu Ser Arg Ile Arg Glu Asp Val Arg Arg Gly Leu Thr Ser Phe 
        35                  40                  45              


Asp Tyr Glu Gln Ile Lys Ala Glu Glu Val Leu Gln Arg Asp Met Ala 
    50                  55                  60                  


Val Tyr Val Ala Phe Ala Ser Asn His Leu Ser Ser Ala Thr Val Asp 
65                  70                  75                  80  


Leu Ser Ile Leu Asp Gly Glu Glu Gly Lys Glu Asp Phe Leu Leu Leu 
                85                  90                  95      


Lys Arg Glu Asp Leu Glu Lys Ser Arg Arg Pro Tyr Leu Arg Arg Asn 
            100                 105                 110         


Leu Leu Gln Phe Phe Gly Gly Glu Ser Thr Trp Gln Asp Phe Ser Phe 
        115                 120                 125             


Glu Lys Tyr Tyr Gln Glu Tyr Ser Ser Ala Asn Ser Thr Gln Tyr Asp 
    130                 135                 140                 


Asp Leu Ser Leu Leu Ser Asp Leu Gln Gln Ile Val Tyr Ala Ala Arg 
145                 150                 155                 160 


Asn Glu Ser Phe His Phe Asp Thr Arg Arg Arg Asn Pro Gly Asn Trp 
                165                 170                 175     


Asn Gln Ser Leu Ile Ser Ala Met Phe Ala His Asp Cys Lys Thr Ala 
            180                 185                 190         


Ser Thr Leu Gln Lys Glu Lys Phe Tyr Ser Asn Asn Leu Pro Met Phe 
        195                 200                 205             


Tyr Gly Glu Lys Asp Leu Leu Asp Leu Leu Arg Val Leu Tyr Gly Lys 
    210                 215                 220                 


Gln Thr Ala Arg Ala Ser Gln Val Pro Ser Phe Asn Lys Val Val Val 
225                 230                 235                 240 


Arg Arg Asn Phe Ser Asn Phe Ile Ser Asp Asn Leu Asn Trp Lys Asn 
                245                 250                 255     


Ile Asn Phe Thr Gly Glu Gly Ser Val Ala Leu Lys Glu Gln Phe Asp 
            260                 265                 270         


Ser Ala Leu Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Leu Phe Leu 
        275                 280                 285             


Gln Gly Arg Gly Ser Gly Ala Ala Phe Asp Val Lys Gly Glu Phe Ile 
    290                 295                 300                 


Lys Trp Cys Leu Asp Glu Lys Asn Gly Lys Gln Asn Ala Glu Ala Phe 
305                 310                 315                 320 


Lys Ser Phe Lys Ser Arg Val Glu Glu Ile Ile Ser Ser Lys Lys Asp 
                325                 330                 335     


Ile Thr Leu Pro Glu Ile Cys Gln Arg Ile Met Thr Asp Tyr Asn Leu 
            340                 345                 350         


Tyr Asn Asn Gly Thr Arg Lys Val Lys Ser Asp Ser Val Lys Gln Asn 
        355                 360                 365             


Met Pro Asp Ser Tyr Asp His Phe Lys Met Leu Leu Leu Lys Gly Leu 
    370                 375                 380                 


Arg Glu Val Phe Ala Ser Tyr Ile Cys Ala Glu Phe Ala Val Leu Lys 
385                 390                 395                 400 


Asn Pro Arg Tyr Arg Glu Lys Pro Asp Ala Asp Ala Phe Leu Pro Asp 
                405                 410                 415     


Tyr Ser Ser Pro Thr Tyr Ser Thr Leu Ile Glu Arg Val Lys Gly Asn 
            420                 425                 430         


Pro Glu Leu Gln Lys Trp Tyr Val Val Gly Arg Leu Leu Asn Pro Arg 
        435                 440                 445             


Gln Ala Asn Phe Phe Val Gly Val Leu Arg Gln Tyr Ile Gln Tyr Thr 
    450                 455                 460                 


Gly Gln Ile Arg Arg Arg Ala Val Glu Thr Gly Ser Arg Met Val Asp 
465                 470                 475                 480 


Thr Ala Ser Ala Lys Ala Leu Lys Gly Tyr Ala Asn Val Leu Glu Val 
                485                 490                 495     


Cys Ile Gln Leu Ala Gly Met Thr Thr Asn Cys Leu Thr Asp Tyr Phe 
            500                 505                 510         


Asp Asp Lys Asp Asp Tyr Ala Arg His Ile Ser Arg Tyr Leu Asp Phe 
        515                 520                 525             


Glu Gly Ile Tyr Pro Gly Ile Ser Ile Ser Ala Gln Leu Glu Asn Phe 
    530                 535                 540                 


Cys Asn Glu Asn Ala Thr Asp Ile Asp Gln Ser Gly Val Ala Gly Ser 
545                 550                 555                 560 


Asn Ser Ala Asn Glu Ser Gly Ser Asp Glu Leu Lys Arg Leu Gly Val 
                565                 570                 575     


Phe Tyr Asp Ala Glu Asn Pro Ile Leu Asn Arg Asn Ile Leu Leu Ser 
            580                 585                 590         


Lys Ile Tyr Gly Thr Glu Lys Ile Leu Val Asn Ile Glu Lys Asn Arg 
        595                 600                 605             


Lys Ile Thr Arg Asp Glu Ile Arg Ala Phe Tyr Glu Gln Arg Glu Lys 
    610                 615                 620                 


Ile Gly Asp Tyr Arg Leu Thr Gly Lys Cys Ser Thr Glu Glu Gln Gln 
625                 630                 635                 640 


Arg Ala Leu Lys Lys Tyr Gln Glu Ile Lys Asn Arg Val Glu Phe Arg 
                645                 650                 655     


Asp Leu Val Glu Tyr Glu Glu Ile Val Asp Glu Met Gln Ala Gln Met 
            660                 665                 670         


Ile Asp Trp Cys Tyr Leu Arg Glu Arg Asp Leu Met Tyr Phe Gln Leu 
        675                 680                 685             


Gly Phe His Tyr Met Cys Leu Cys Asn Ser Ser Ser Lys Ala Glu Leu 
    690                 695                 700                 


Tyr Arg Gly Ile Glu Lys Asp Gly Arg Lys Ile Asp Gly Ala Ile Leu 
705                 710                 715                 720 


Tyr Gln Ile Ala Ala Met Tyr Ile Asn Gly Leu Pro Ile Tyr Ala Val 
                725                 730                 735     


Glu Lys Gly Lys Ile Lys Arg Lys Ser Glu Ser Met Ser Ala Gly Gly 
            740                 745                 750         


Lys Ile Arg Val Phe Leu Asn Tyr Ala Gly Ala Cys Val Glu Gln Ala 
        755                 760                 765             


Ala Ser Ser Lys Glu Ala Glu Ala Pro Ile Ser Ala Asp Ala Ala Glu 
    770                 775                 780                 


Arg Phe Tyr Leu Ala Gly Met Glu Leu Phe Glu Asn Thr Gln Glu His 
785                 790                 795                 800 


Asp Asn Ile Val Ala Leu Arg Asn Tyr Ile Glu His Phe His Tyr Tyr 
                805                 810                 815     


Val His Gln Asp Arg Ser Leu Leu Asp Leu Tyr Gly Glu Ile Phe Asp 
            820                 825                 830         


Arg Phe Phe Thr Tyr Asp Met Lys Tyr Gln Lys Asn Val Cys Asn Ile 
        835                 840                 845             


Leu Tyr Asn Ile Leu Met His His Phe Val Arg Pro Ala Phe Thr Phe 
    850                 855                 860                 


Ser Lys Ala Glu Lys Gln Val Gly Lys Ile Thr Lys Asp Arg Ala Ser 
865                 870                 875                 880 


Ile Ser Leu Val Glu Lys Lys Gly Leu Ser Ser Glu Lys Met Thr Tyr 
                885                 890                 895     


Lys Leu Ala Ser Pro Asn Lys Lys Gln Gln Gly Asn Thr Ser Ser Ala 
            900                 905                 910         


Asp Ile Gly Ser Ala Glu Glu Ala Lys Lys Met Asp Leu Pro Ala Lys 
        915                 920                 925             


Ser Arg Asp Phe Leu Glu Gly Val Ala Val Leu Leu Ser Tyr Pro Asp 
    930                 935                 940                 


Glu Pro Gly Asp Val Val Ser Glu Glu Arg His Asn Asn Arg Gln Ser 
945                 950                 955                 960 


Tyr Thr Thr Thr Lys Thr Glu Glu Asn Asp Asn Ser Arg Gly Lys Asp 
                965                 970                 975     


Gln Arg Arg Asn Asn Ser Gly Thr Gln Glu Thr Asn Trp Lys Gly Arg 
            980                 985                 990         


Gly Ala Asn Ala Asp Asn Arg Pro  Ser Gly Gly Gln Gly  Lys Ser Gly 
        995                 1000                 1005             


Ser Phe  Gly Thr Ser Leu Ala  Asp Leu Leu Lys Asp  Phe Lys Phe 
    1010                 1015                 1020             


Asp Glu  
    1025 


<210>  1172
<211>  1227
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1172

Met Val Val Ser Thr Lys Tyr Val Val Asp Asp Val Val Arg Asn Ser 
1               5                   10                  15      


Ser Arg Leu Tyr Ser Pro Phe Asn Ser Lys Lys Leu Ile Ile Asp Asp 
            20                  25                  30          


Lys Thr Lys Val Val Ala Asn Ser Leu Arg Gln His Phe Lys Asn Phe 
        35                  40                  45              


Val Lys Ile Tyr Leu Asn Cys Glu Ser Ile Asp Glu Gln Gln Met Lys 
    50                  55                  60                  


Phe Thr Pro Asp Asn Lys Tyr Leu Met Asp Asn Arg Val Arg Ile Ser 
65                  70                  75                  80  


Leu Pro Ser Asp Val Asn Glu Glu Lys Leu Val Glu Ala Ile Val Asn 
                85                  90                  95      


Ser Ser Leu Arg Lys Ser Leu Asn Lys Lys Cys Asn Ile Gln Ile Lys 
            100                 105                 110         


Ala Gly Leu Arg Glu Thr Phe Asp Ile Pro Glu Leu Ile Lys Lys Ala 
        115                 120                 125             


Ile Lys Ile Tyr Cys Ile Asp Glu Lys Arg Asn Leu Asn Asp Ala Glu 
    130                 135                 140                 


Lys Leu Asp Met Tyr Ala Leu Phe Ser Phe Met Tyr Glu Asp Lys Tyr 
145                 150                 155                 160 


Lys Asn Arg Gln Lys Lys Leu Ile Ile Asn Ser Ile Ser Asn Gln Val 
                165                 170                 175     


Thr Lys Val Lys Val Cys Glu Asn Gly Asn Arg Leu Leu Lys Leu Ser 
            180                 185                 190         


Ile Ala Asp Thr Lys Lys Lys Pro Leu Trp Asp Phe Met Ile Glu Tyr 
        195                 200                 205             


Ser Asn Ser Asp Lys Lys Lys Gln Asp Thr Met Leu Arg Asn Ile Arg 
    210                 215                 220                 


Lys Ser Ile Val Leu Phe Val Cys Gly Val Glu Asn Tyr Lys Asn Ile 
225                 230                 235                 240 


Glu Asn Asp Asn Lys Leu Asp Ile Cys Ser Trp Asp Gly Tyr Asp Ile 
                245                 250                 255     


Asn Glu Asn Gln Gln Phe Val Cys Val Asn Thr Asn Asn Ser Asn Asp 
            260                 265                 270         


Asp Tyr Phe Ile Ser Ser Thr Glu Leu Arg Arg Ala Asn Leu Asp His 
        275                 280                 285             


Tyr Met Lys Ala Val Ala Lys Leu Asn Asp Asp Arg Asn Lys Phe Trp 
    290                 295                 300                 


Phe Gln His Phe Glu Ser Val Ile Glu Thr Phe Phe Ser Lys Lys Ala 
305                 310                 315                 320 


Lys Arg Asn Ile Glu Arg Ile Lys Ser Ala Tyr Leu Cys Glu Tyr Leu 
                325                 330                 335     


Trp Arg Asp Phe Cys Ser Tyr Val Ala Leu Lys Tyr Val Asp Leu Gly 
            340                 345                 350         


Lys Gly Val Tyr His Phe Thr Met Ala Asp Lys Leu Ala Leu Ile Asn 
        355                 360                 365             


Arg Asn Lys Tyr Glu Lys Ser Ile Ile Phe Gly Glu Ile Glu Ser Arg 
    370                 375                 380                 


Tyr Asn Asn Gly Ile Ser Ser Phe Asp Tyr Glu Arg Ile Lys Ala Glu 
385                 390                 395                 400 


Glu Leu Phe Glu Arg Asn Ile Ser Thr Tyr Thr Thr Phe Ala Thr Asn 
                405                 410                 415     


Ile Phe Ser Lys Ala Val Val Gln Asp Asp Tyr Ile Lys Asn His Asn 
            420                 425                 430         


Lys Ala Ser Asp Val Leu Gln Tyr Ser Asp Lys Glu Phe Ser Asp Ser 
        435                 440                 445             


Lys Val Leu Arg Asn Asp Ala Met Lys Arg Ile Leu Gln Tyr Trp Gly 
    450                 455                 460                 


Gly Gln Ser Arg Trp Asn Asn Thr Leu Asn Lys Ile Asn Val Asp Thr 
465                 470                 475                 480 


Leu Cys Ile Asp Ile Lys Glu His Leu Ser Asn Ile Arg Asn Ser Ser 
                485                 490                 495     


Val His Tyr Thr Ser Lys Val Ser Leu Ser Gly Asp Lys Asn Glu Ser 
            500                 505                 510         


Ile Val Tyr Met Leu Phe Lys Lys Asp Phe Ala Glu Ile Arg Asn Ile 
        515                 520                 525             


Phe Ala Ser Lys Tyr Tyr Ser Asn Asn Val Trp Met Phe Tyr Ser Ile 
    530                 535                 540                 


Glu Lys Ile Asn Gly Leu Met Glu Tyr Leu Tyr Gly Asp Asn Ser Thr 
545                 550                 555                 560 


Val Ile Asp Ala Gln Ile Pro Ala Tyr Asn Asn Ile Ile Lys Arg Lys 
                565                 570                 575     


Asn Ile Ala Asp Val Ile Glu Lys Ile Ile Lys Lys Asn Ser Tyr Lys 
            580                 585                 590         


Thr Ile Asn Glu Leu Glu Leu Ile Lys Lys Tyr Arg Ala Cys Leu Tyr 
        595                 600                 605             


Phe Ile Leu Lys Glu Ile Tyr Tyr Asn Arg Phe Ile Lys Gln Glu Asn 
    610                 615                 620                 


Leu Lys Glu Gln Phe Ile Gln Phe Val Asp Asn Asp Asn Asn Leu Leu 
625                 630                 635                 640 


Asp Asp Asn Lys Asn Ala Val Glu Ser Phe Arg Arg Arg Ile His Asp 
                645                 650                 655     


Ile Asp Asn Ser Leu Met Ser Phe Gly Glu Met Cys Gln Phe Ile Met 
            660                 665                 670         


Thr Asp Tyr Asn Met Gln Asn Gln Gly Asn Lys Ser Ile Lys Ser Lys 
        675                 680                 685             


Asp Arg Gln Asn Glu Asp Lys Lys Lys Gly Ile Asp Gly Ser Tyr Lys 
    690                 695                 700                 


His Phe Pro Leu Leu Leu Tyr His Val Ile Lys Glu Leu Phe Leu Lys 
705                 710                 715                 720 


Tyr Ile Lys Thr Asp Glu Lys Ile Val Phe Ile Arg Glu Pro Ala Asn 
                725                 730                 735     


Ile Gly Ser Val Lys Thr Gln Asp Glu Phe Glu Thr His Ile Ser Thr 
            740                 745                 750         


Leu Gly Leu Tyr Lys Thr Leu Lys Glu Lys Val Asp Ser Asn Met Ser 
        755                 760                 765             


Leu Leu Asp Trp Tyr Thr Leu Ser His Phe Leu Met Pro Lys Gln Leu 
    770                 775                 780                 


Asn Tyr Leu Ile Gly Asp Ile Lys Asn Tyr Ile Gln Tyr Leu Arg Asn 
785                 790                 795                 800 


Ile Asp Lys Arg Ala Glu Ser Val Gly Asn Asn Lys Ala Tyr Asp Ile 
                805                 810                 815     


Asp Gly Lys Ile Asn Asn Tyr Tyr Asp Ile Val Tyr Val Leu Asp Phe 
            820                 825                 830         


Ser Leu Gln Tyr Ile Gly Arg Ile Ser Asn Glu Ile Thr Asp Tyr Phe 
        835                 840                 845             


Ala Asp Glu Asp Glu Tyr Ala Leu Phe Met Ser Gln Phe Val Asp Phe 
    850                 855                 860                 


Ser Ser Asp Asn Ile Val Gly Leu Lys Thr Phe Cys Asn Glu Lys Thr 
865                 870                 875                 880 


Ser Asn Gly Lys His Thr Ile Gly Leu Tyr Cys Asp Gly Ala Asn Pro 
                885                 890                 895     


Ile Met Asn Arg Asn Ile Ala Tyr Ala Lys Met Tyr Ser Asn Asp Lys 
            900                 905                 910         


Ile Leu Ser Arg Thr Tyr Ser Lys Val Thr Ile Lys Glu Ile Glu Arg 
        915                 920                 925             


Tyr Tyr Arg Ile Gln Asp Asp Leu Lys Asn Val Phe Glu Asn Gly Val 
    930                 935                 940                 


Cys Lys Asn Lys Asp Gln Gln Lys Glu Leu Cys Asp Phe Gln Lys Ile 
945                 950                 955                 960 


Lys Asn His Ile Glu Leu Thr Glu Ile Ser Ile Tyr Thr Asn Ile Leu 
                965                 970                 975     


Asn Asp Phe Met Ser Gln Phe Ile Ser Trp Ser Tyr Leu Arg Glu Arg 
            980                 985                 990         


Asp Leu Met Tyr Phe Gln Leu Gly  Met His Tyr Leu Arg  Leu Tyr Tyr 
        995                 1000                 1005             


Gly Thr  Asn Glu Leu Glu Thr  Lys Tyr Asn Lys Leu  Val Gly Glu 
    1010                 1015                 1020             


Ser Val  Asn Ile Glu Lys Gly  Ala Leu Leu Tyr Gln  Ile Ala Ala 
    1025                 1030                 1035             


Met Tyr  Thr Tyr Lys Leu Pro  Ile Tyr Lys Val Asp  Lys Asn Gly 
    1040                 1045                 1050             


Ser Ala  Val Leu Ala Glu Lys  Gln Gly Gly Thr Gly  Ala Ser Val 
    1055                 1060                 1065             


Thr Ser  Phe Val Thr Glu Tyr  Cys Lys Glu Asn Met  Arg Asp Ala 
    1070                 1075                 1080             


Ile Ile  Tyr Glu Lys Gly Leu  Glu Leu Phe Glu Asp  Val Lys Gln 
    1085                 1090                 1095             


His Lys  Lys Trp Ser Asp Phe  Arg Asn Asp Ile Ala  His Met Arg 
    1100                 1105                 1110             


Tyr Ile  Ser Asp Arg Asp Lys  Ser Ile Met Asp Ile  Ile Ser Glu 
    1115                 1120                 1125             


Ile Tyr  Gly Gly Phe Phe Thr  Tyr Asp Ile Lys Leu  Lys Lys Ser 
    1130                 1135                 1140             


Ile Pro  Val Ile Phe Lys Asn  Ile Leu Met Arg Tyr  Ala Val Asp 
    1145                 1150                 1155             


Ala Asn  Leu Asn Phe Leu His  Lys Glu Asn Arg Lys  Leu Lys Asp 
    1160                 1165                 1170             


Thr Leu  Ile Asn Ile Arg Ala  Asp Lys Gly Leu Val  Ser Asp Lys 
    1175                 1180                 1185             


Tyr Thr  Tyr Lys Ile Gly Glu  Lys Asp Thr Val Asp  Ile Glu Val 
    1190                 1195                 1200             


Arg Asn  Asp Lys Phe Leu Leu  Gln Leu Arg Lys Leu  Leu Glu Tyr 
    1205                 1210                 1215             


Lys Ile  Arg Val Asn Gly Asn  Val Leu 
    1220                 1225         


<210>  1173
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1173

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Gly Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  1174
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1174

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Gly Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  1175
<211>  1382
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1175

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Asp Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn Tyr Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Gly Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Gly Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Lys Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Arg Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Asp Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Lys Tyr  Gln Lys Asn 
    1220                 1225                 1230             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1235                 1240                 1245             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1250                 1255                 1260             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1265                 1270                 1275             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1280                 1285                 1290             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1295                 1300                 1305             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1310                 1315                 1320             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1325                 1330                 1335             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1340                 1345                 1350             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1355                 1360                 1365             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1370                 1375                 1380         


<210>  1176
<211>  1353
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1176

Met Lys Val Thr Lys Ala Glu Lys Leu Arg Val Ala Val Ser Arg Lys 
1               5                   10                  15      


Leu Asn Asn Glu Asp Lys Arg Ala Val Leu Tyr Lys Thr Pro Asn Pro 
            20                  25                  30          


Gly Gln Thr Cys Gly Thr Val Lys Lys Gln Leu Ala Asn Arg Val Glu 
        35                  40                  45              


Arg Ala Asn Lys Leu Tyr Gly Val Phe Phe Arg Ser Asp Val Pro Glu 
    50                  55                  60                  


Thr Leu Gln Tyr His Phe Glu Glu Leu Val Thr Tyr Ala Ala Gln Ser 
65                  70                  75                  80  


Thr Ser Pro Asn Glu Phe Arg Gln Lys Ala Ser Gln Tyr Arg Glu Cys 
                85                  90                  95      


Glu Lys Lys Asp Lys Phe Gly Lys Met Arg Lys Tyr Pro Ile Phe Arg 
            100                 105                 110         


Cys Ser Tyr Ala Pro Ser Gly Lys Asn Met Lys Lys Val Met Glu Leu 
        115                 120                 125             


Tyr Val Arg Glu Arg Met Lys Asp Glu Trp Gln Ser Gln Ala Tyr Arg 
    130                 135                 140                 


Thr Ala Ala Ile Glu Ile Leu Leu Cys Ile Cys Asn Lys Asp Phe Ser 
145                 150                 155                 160 


Lys Gln Leu Ser Arg Val Asp Ala Arg Ile Phe Ala Asp Phe Tyr Asn 
                165                 170                 175     


Ala Ser Lys Ala Cys Pro Gln Pro Tyr Ile Gly Lys Ser Thr Gly Val 
            180                 185                 190         


Leu Glu Ala Ala Phe Thr Ser Val Met Lys Gln Met Ser Leu His Ala 
        195                 200                 205             


Lys Ala Asn Ala Ser Asn Lys Ile Trp Trp Leu Gln Asn Gln Leu Arg 
    210                 215                 220                 


Thr Ile Glu Leu Asn Lys Lys Ile Val Lys Ile Ser Asp Phe Lys Tyr 
225                 230                 235                 240 


Glu Tyr Ala Thr Glu Asp Arg Met Arg Ala Ile Leu Val Arg Met Arg 
                245                 250                 255     


Lys Ser Leu Lys Arg Gly Thr Asn Gly Asp Ile Ala Val Ala Leu Leu 
            260                 265                 270         


Gln Gly Ile Ala Gln Met Asn Gly Lys Thr Leu Ser Gly Val Leu Glu 
        275                 280                 285             


Glu Leu Ser Ala Asn Ser Glu Thr Lys Glu Gln Leu Ile Lys Phe Leu 
    290                 295                 300                 


Lys Ala Val His Glu Asp Tyr His Lys Thr Pro Ile Leu Lys Ala Ile 
305                 310                 315                 320 


Arg Asn Gln Asp Val Lys Val Gln Val His Glu Val Asp Pro Val Ser 
                325                 330                 335     


Pro Glu Gly Arg Ala Leu Asp Leu Ala Ser Ile Asn Val Ser Lys Gly 
            340                 345                 350         


Asn Glu Arg Lys Lys Tyr Lys Val Ala Leu Thr Gln Thr Leu Gly Asn 
        355                 360                 365             


Tyr Ala Lys Ser Pro Lys Asp Ala Thr Gln Thr Leu Lys Ala Ile Lys 
    370                 375                 380                 


Gly Val Leu Leu Asp Tyr Phe Met Trp Leu Asp Ser Asp Val Lys Ala 
385                 390                 395                 400 


Glu Phe Leu Glu Asp Asn Asn Leu Trp Lys Ile Pro Asn Arg Thr Glu 
                405                 410                 415     


Glu Tyr Phe Asp Asn Asn Phe Val Pro Ile Asp Asp Lys Lys Asp Asp 
            420                 425                 430         


Lys Ile Glu Ala Ile Glu Asp Phe Ala Ser Ile Trp Arg Gln Glu Arg 
        435                 440                 445             


Val Lys Asn Ser Arg Ile Lys Ala Arg Met Asn Tyr Val Asn Cys Gly 
    450                 455                 460                 


Lys Tyr Gln Gln Leu Ile Lys Gln Glu Thr Asp Asp Phe Arg Ile Cys 
465                 470                 475                 480 


Trp Ile Ser Tyr Ala Lys Asp Phe Val Glu Lys Asn Tyr Val Ser Lys 
                485                 490                 495     


Asn Arg Gln Phe Thr Gln Gly Asp Cys Phe Ser Thr Lys Met Leu Leu 
            500                 505                 510         


Glu Cys Trp Lys Glu Ile Ile Arg Phe Ile Cys Gly Lys Tyr Ile Asp 
        515                 520                 525             


Ile Gly Lys Ala Val Tyr His Phe Ala Met Pro Glu Thr Met Asn Ala 
    530                 535                 540                 


Arg Asp Ser Leu Ala Tyr Gly Val Leu Gly Glu Lys Tyr Lys Glu Gly 
545                 550                 555                 560 


Ile Ser Ser Phe Asp Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln 
                565                 570                 575     


Arg Asp Ile Ala Lys Ala Ala Val Ala Ala Ile His Ala Phe Ser Gly 
            580                 585                 590         


Ser Val Ile Asp Asp Lys Lys Pro Val Glu Asp Ile Leu Phe Ile Lys 
        595                 600                 605             


Asp Glu Glu Leu Gln Glu His Ala Lys Ala Asp Asp Val Ile Val Lys 
    610                 615                 620                 


Gln Ile Leu Arg Phe Tyr Gly Gly Phe Ser Ser Val Glu Gly Arg Glu 
625                 630                 635                 640 


Lys Leu Glu Gly Met Ala Leu Ala Lys Glu Val Leu Ser Gln Leu Lys 
                645                 650                 655     


Ala Ile Arg Asn Glu Asn Phe His Phe Thr Gln Gly Lys Arg Lys Asn 
            660                 665                 670         


Val Glu Glu Asn Ile Pro Leu Thr Lys Ala Leu Trp Glu Asn Glu Glu 
        675                 680                 685             


Lys Val Tyr Arg Gln Thr Val Lys Glu Thr Tyr Tyr Ser Asn Asn Val 
    690                 695                 700                 


Ser Met Phe Tyr Ser Gln Glu Val Ile Gln Lys Leu Val Ala Glu Leu 
705                 710                 715                 720 


Tyr Gln Asn Asn Asn Val Ala Glu Ala Gln Ile Pro Ala Phe Arg Thr 
                725                 730                 735     


Ile Trp Lys Arg Lys Asp Leu Pro Glu Tyr Ile Gly Ser Leu Asn Ile 
            740                 745                 750         


Ser Trp Asp Lys Thr Glu Pro Lys Gln Val Ile Tyr Glu Gly Ala Leu 
        755                 760                 765             


Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Lys Ser Gly 
    770                 775                 780                 


Glu Ala Lys Lys Leu Phe Phe Asp Ala Val Met Asp Asn Ala Thr Glu 
785                 790                 795                 800 


Met Glu Lys Ser Ser Asn Ala Asp Ser Arg Asn Gln Glu Lys Lys Ala 
                805                 810                 815     


Leu Ala Asn Ala Gly Lys Asn Phe Arg Asp Tyr Val Asn Gly Leu Asn 
            820                 825                 830         


Ala Ser Thr Leu Gly Glu Val Cys Gln Phe Ile Gln Asn Glu Tyr Asn 
        835                 840                 845             


Gln Gln Asn Arg Gly Lys Gln Glu Gln Glu Ile Tyr Lys His Phe Lys 
    850                 855                 860                 


Met Leu Leu Pro Ile Cys Met Arg Lys Ala Phe Gln Arg Tyr Ile Asp 
865                 870                 875                 880 


Glu Lys His Ser Phe Ile Lys Lys Pro Gly Glu Leu Pro Gln Thr Thr 
                885                 890                 895     


Glu Asp Tyr Leu Glu Asn Val Lys Val Ala Cys Pro Glu Lys Lys Ile 
            900                 905                 910         


Lys Leu Gly Arg Trp Phe Thr Phe Ala His Phe Ile His Pro Arg Glu 
        915                 920                 925             


Leu Asn Phe Leu Ile Gly Asp Phe Lys Asn Tyr Ile Gln Tyr Arg Glu 
    930                 935                 940                 


Asp Val Leu Arg Arg Ser Glu His Ala Gly Gln Phe Ser Asp Thr Thr 
945                 950                 955                 960 


Glu Arg Asp Gly Glu Lys Ala Val Val Asp His Ala Val Gln Lys Ala 
                965                 970                 975     


Lys Asp Ile Leu Gly Val Leu Glu Phe Val Arg His Ile Ser Gly Arg 
            980                 985                 990         


Val Ser Asn Glu Phe Thr Asp Tyr  Tyr Ala Asp Arg Ala  Glu Tyr Asp 
        995                 1000                 1005             


Glu Tyr  Met Ala Lys Tyr Phe  Glu Pro Asp Val Gln  Ile Glu Gln 
    1010                 1015                 1020             


Tyr Asp  Leu Tyr Gly Asp Ala  Lys Asn Ala Lys Val  Ile Arg Asn 
    1025                 1030                 1035             


Ile Glu  Leu Ala Arg Met Tyr  Ala Gly Asp Ser Leu  Met Ser Ala 
    1040                 1045                 1050             


Ser Tyr  Arg Lys Ile Thr Lys  Lys Glu Ile Glu Thr  Tyr Tyr Ala 
    1055                 1060                 1065             


Lys Lys  Asp Glu Ile Ala Gln  Leu Gln Ser Gln Gly  Ile Cys Asn 
    1070                 1075                 1080             


Ser Lys  Lys Glu Gln Glu Asp  Ile Val Ala Phe Gln  Lys Leu Lys 
    1085                 1090                 1095             


Asn Arg  Ile Thr Leu Asn Glu  Val Thr Asp Leu Trp  Ser Leu Val 
    1100                 1105                 1110             


Asn Glu  Leu Leu Gly Asn Leu  Val Ser Leu Ala Tyr  Leu Arg Glu 
    1115                 1120                 1125             


Arg Asp  Glu Met Tyr Leu Phe  Leu Gly Phe Tyr Tyr  Met Ala Leu 
    1130                 1135                 1140             


Arg His  Pro Glu Gly Trp Thr  Asn Glu Ile Met Asn  Ser Val Ser 
    1145                 1150                 1155             


Asn Glu  Lys Tyr Ala Val Lys  Glu Gly Leu Val Leu  Tyr Gln Thr 
    1160                 1165                 1170             


Val Ala  Val Phe Asp Phe Gly  Thr Lys Leu Leu Phe  Gln Asn Asp 
    1175                 1180                 1185             


Asn Gln  Lys Trp Glu Glu Thr  Thr Gly Tyr Lys Trp  Gln His Phe 
    1190                 1195                 1200             


Ile Asp  Asn His Lys Glu Ser  Tyr Ala Cys Ile Leu  Pro Leu Phe 
    1205                 1210                 1215             


Glu Ile  Ala Lys Cys Glu Thr  Glu Ala Arg Ala Val  Arg Asn Tyr 
    1220                 1225                 1230             


Val Asp  His Phe Lys Tyr Tyr  Ser Asn Glu Asp Arg  Ser Ile Leu 
    1235                 1240                 1245             


Glu Leu  Tyr Gly Lys Phe Tyr  Thr His Leu Phe Gly  Tyr Ser Thr 
    1250                 1255                 1260             


Arg Leu  Arg Lys Ser Val Leu  Gln Ile Leu Ala Gln  Thr Leu Glu 
    1265                 1270                 1275             


Lys His  Gly Ile Ser Ala Gly  Ile Gln Phe Asp Gly  Thr Thr Val 
    1280                 1285                 1290             


Lys Ala  Thr Arg Cys Asp Met  Lys Ser Val Glu Phe  Thr Tyr Lys 
    1295                 1300                 1305             


Tyr Glu  Glu Lys Leu Asn Glu  Gln Lys Thr Val Leu  Arg Thr Ile 
    1310                 1315                 1320             


Ser Leu  Pro Ala Lys Ser Glu  Gly Phe Ile Thr Ala  Val Cys Glu 
    1325                 1330                 1335             


Met Leu  Lys Gln Lys Lys Gly  Asp His Thr Glu Asn  Thr Leu Cys 
    1340                 1345                 1350             


<210>  1177
<211>  1385
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1177

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Pro Gly Thr Asp Thr 
            20                  25                  30          


Ile Asp Leu Asn Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Thr Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Asp Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Glu Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Gly Leu Phe Val Asn Ile 
                325                 330                 335     


Pro Asp Val Leu Met Lys Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Ile Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Ser Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg 
465                 470                 475                 480 


Asn Gly Ile Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Tyr Glu Asn 
                485                 490                 495     


Leu Gln Arg Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu 
            500                 505                 510         


Ala Arg Ala Val Cys Asp Met Ser Asn Leu Lys Asp Arg Glu Ser Asp 
        515                 520                 525             


Phe Leu Leu Trp Lys Lys Glu Asp Ile Ala Asp Lys Leu Lys Asn Lys 
    530                 535                 540                 


Asp Asp Met Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys 
545                 550                 555                 560 


Ser Ser Trp Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn 
                565                 570                 575     


Lys Tyr Asn Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile 
            580                 585                 590         


Tyr Cys Ala Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn 
        595                 600                 605             


Asn Glu Lys Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu 
    610                 615                 620                 


Thr Glu Phe Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn 
625                 630                 635                 640 


Leu Tyr Met Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Gln 
                645                 650                 655     


Leu Tyr Ser Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn 
            660                 665                 670         


Ser Val Phe Ile Arg Lys Asn Phe Pro Glu Asp Ile Thr Asn Val Leu 
        675                 680                 685             


Arg Tyr Gln Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr 
    690                 695                 700                 


Ser Ala Cys Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu 
705                 710                 715                 720 


Gln Ser Asp Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu 
                725                 730                 735     


Ser Trp Asp Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn 
            740                 745                 750         


His Phe Ser Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys 
        755                 760                 765             


Gln Ile Tyr Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys 
    770                 775                 780                 


Val Arg Ser Ser Asn Asp Ser Ile Phe Asp Lys Pro Ile Tyr His His 
785                 790                 795                 800 


Tyr Lys Val Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr 
                805                 810                 815     


Leu Lys Tyr Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys 
            820                 825                 830         


Ala Asn Glu Ile Arg Lys Ile Asp Lys Glu Arg Phe Leu Pro Asp Trp 
        835                 840                 845             


Thr Ser Thr Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln 
    850                 855                 860                 


Glu Leu Gln Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser 
865                 870                 875                 880 


Leu Asn Leu Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr 
                885                 890                 895     


Asp Ile Lys Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser 
            900                 905                 910         


Val Gln Asp Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val 
        915                 920                 925             


Cys Ser Leu Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe 
    930                 935                 940                 


Asn Asp Lys Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe 
945                 950                 955                 960 


Ser Asn Ala Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser 
                965                 970                 975     


Asn Glu Glu Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val 
            980                 985                 990         


Asn Arg Asn Ile Val His Ser Lys  Leu Phe Ala Ala Asp  His Ile Leu 
        995                 1000                 1005             


Arg Asp  Ile Val Glu Pro Val  Ser Lys Asp Asn Ile  Glu Glu Phe 
    1010                 1015                 1020             


Tyr Asp  Gln Lys Ala Glu Ile  Val Tyr Cys Lys Ile  Lys Gly Lys 
    1025                 1030                 1035             


Asp Ile  Thr Ala Glu Glu Gln  Lys Ala Val Leu Lys  Tyr Gln Lys 
    1040                 1045                 1050             


Leu Lys  Asn Arg Val Glu Leu  Arg Asp Ile Val Glu  Tyr Gly Glu 
    1055                 1060                 1065             


Ile Ile  Asn Glu Leu Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met 
    1070                 1075                 1080             


Arg Glu  Arg Asp Leu Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn 
    1085                 1090                 1095             


Cys Leu  Arg Asn Asn Ser Glu  Lys Lys Glu Ala Tyr  Gln Lys Ile 
    1100                 1105                 1110             


Glu Val  Asn Gly Asp Ser Ile  Lys Asp Ala Ile Leu  Tyr Gln Ile 
    1115                 1120                 1125             


Ile Gly  Met Tyr Val Asn Gly  Val Ala Val Tyr Ala  Pro Asp Glu 
    1130                 1135                 1140             


Lys Gly  Asp Ile Leu Lys Glu  Gln Cys Thr Lys Gly  Gly Ala Gly 
    1145                 1150                 1155             


Gly Lys  Ile Ser Ala Phe Asn  Arg Tyr Ser Glu Tyr  Leu Gly Leu 
    1160                 1165                 1170             


Asp Lys  Leu Thr Leu Tyr Asn  Ala Gly Leu Glu Ile  Phe Glu Val 
    1175                 1180                 1185             


Val Ala  Glu His Asp Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp 
    1190                 1195                 1200             


His Phe  Lys Tyr Tyr Leu Gly  Asp Tyr Arg Ser Met  Leu Ser Ile 
    1205                 1210                 1215             


Tyr Ser  Glu Val Phe Asp Arg  Phe Phe Thr Tyr Asp  Ile Lys Tyr 
    1220                 1225                 1230             


Gln Lys  Asn Val Leu Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His 
    1235                 1240                 1245             


Asn Val  Ile Val Glu Pro Val  Leu Glu Ser Gly Phe  Lys Thr Ile 
    1250                 1255                 1260             


Gly Lys  Gln Thr Thr Ser Gly  Ala Lys Leu Ser Ile  Arg Ser Ile 
    1265                 1270                 1275             


Lys Ser  Asp Thr Phe Gln Tyr  Lys Val Lys Gly Gly  Ser Leu Ile 
    1280                 1285                 1290             


Thr Asp  Ala Lys Asp Glu Arg  Tyr Leu Lys Thr Ile  Arg Lys Ile 
    1295                 1300                 1305             


Leu Tyr  Tyr Val Glu Asn Glu  Glu Asp Asn Leu Lys  Lys Ser Val 
    1310                 1315                 1320             


Val Val  Thr Asn Ala Asp Lys  Tyr Glu Lys Asn Lys  Glu Ser Asp 
    1325                 1330                 1335             


Asp Gln  Asn Lys Gln Lys Glu  Lys Lys Asn Lys Asp  Asn Lys Gly 
    1340                 1345                 1350             


Lys Lys  Asn Glu Glu Thr Lys  Ser Asp Ala Gly Lys  Asn Asn Asn 
    1355                 1360                 1365             


Glu Arg  Leu Ser Tyr Asn Pro  Phe Ala Asn Leu Asn  Phe Lys Leu 
    1370                 1375                 1380             


Pro Asn  
    1385 


<210>  1178
<211>  1197
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1178

Met Gln Ile Ile Lys Pro Tyr Gly Arg Ser His Val Glu Glu Asn Arg 
1               5                   10                  15      


Ala Ala Gly Thr Arg Arg Val Leu Ser Leu Arg Leu Asp Pro Glu Lys 
            20                  25                  30          


Arg Met Asp Ile Val Glu Phe Ala Arg Ser His Glu Lys Leu Val Val 
        35                  40                  45              


Ala Gln Trp Ile Ser Thr Ile Asp Lys Ile Ala Ser Lys Pro Ala Gly 
    50                  55                  60                  


Glu Asn Gly Pro Thr Glu Glu Gln Arg Ala Phe Arg Gln Arg Leu Gly 
65                  70                  75                  80  


Asp Ala Ala Trp Thr Leu Leu Glu Ala Lys Gly Leu Leu Pro Gly Val 
                85                  90                  95      


Lys Gln Pro Glu Val Lys Gln Gln Leu Ala Lys Leu Trp Lys Val Lys 
            100                 105                 110         


Ile Ala Pro Tyr Gly Thr Ala Arg Tyr Arg Ala Glu Lys Asn Arg Lys 
        115                 120                 125             


Pro Pro Ser Val Arg Gly Arg Trp Tyr Asp His Phe Ser Glu Gly Val 
    130                 135                 140                 


Ala Asp Val Ala Asn Val Asp Ala Ala Glu Val Ala Lys Lys Ile His 
145                 150                 155                 160 


Glu His Leu Tyr Ile Ala Gly Tyr Arg Ile Gly Thr Gly Val Arg Asn 
                165                 170                 175     


Arg Arg Gln Gly His Ile Ala Ala Arg Ala Lys Ser Ile Ala Val Asn 
            180                 185                 190         


Val Leu Arg Thr Gly Leu Pro Ala Tyr Gly Gly Gly Val Gly Ala Gly 
        195                 200                 205             


Trp Met Ala Glu Asp Arg Asp Ser Tyr Ala Lys Ala Gly Asn Phe Val 
    210                 215                 220                 


Gln Glu Ile Arg Leu Ala Ala Glu Arg Arg Glu Arg Gly Glu Asp Lys 
225                 230                 235                 240 


Ala Gly Thr Leu Arg Val Thr Ser Ser Ile Ala Gly Lys Ala Leu Phe 
                245                 250                 255     


Glu His Tyr Ala Arg Leu Phe Lys Arg Ala Asp Gly Lys Ala Leu Ser 
            260                 265                 270         


Ile Arg Glu Ala Arg Glu Arg Thr Pro Gly Leu Phe Asn Leu His Met 
        275                 280                 285             


Ala Val Lys Asp Cys Tyr Ser Arg Ile Leu Lys Asn His Lys Lys Asp 
    290                 295                 300                 


Leu Lys Ala His Gly Asp Arg Arg Arg Lys Val Ser Ala Leu Leu Pro 
305                 310                 315                 320 


Ser Thr Met Asp Gly Leu Phe Ala Leu Leu Asp Ala Lys Arg Thr Asn 
                325                 330                 335     


Arg Asp Leu Asn Thr Leu Val Arg Leu Gly Lys Val Ile His Tyr Lys 
            340                 345                 350         


Ser Ser Gly Gly Val Glu Asp Trp Pro Ser Asp Pro Val His Asn Trp 
        355                 360                 365             


Pro Ala Asp Val Thr Arg Ser Phe Phe Trp Thr Ser Asp Gly Gln Ala 
    370                 375                 380                 


Ile Met Lys Arg Asn Glu Ala Phe Val Arg Val Trp Arg His Val Leu 
385                 390                 395                 400 


Ala Leu Ala Ser Arg Thr Leu Thr Asp Trp Ala Asp Pro Asp Gly Lys 
                405                 410                 415     


Ile Arg Ser Asp Ile Leu Leu Ser Gly Pro Ile Glu Arg Ala Thr Gly 
            420                 425                 430         


Asp Cys Phe Asp Asn Gly Asn Tyr Ala Arg Lys Leu Ala Leu Leu Phe 
        435                 440                 445             


Gly Ser Arg Ala Asp Ile Phe Gln Cys Ala Gly Asp Asp Ala Val Gln 
    450                 455                 460                 


Lys Asn Val Leu Arg His Ala Leu Glu Gly Ile Ala Gly Leu Arg His 
465                 470                 475                 480 


Ser Ser Phe His Phe Lys Gly Leu Gly Gly Phe Ala Asp Ala Leu Thr 
                485                 490                 495     


Arg Ser Gln Phe Ala Leu Asp Glu Asn Val Ile Gly Ala Val Arg Gln 
            500                 505                 510         


Leu Trp Gln Ala Asp Val Gly Gly Arg Ala Gly Gln Leu Leu Lys Thr 
        515                 520                 525             


Met Arg Ala Ala His Phe Glu Tyr Phe Leu Gly Glu Ser Gln Asn Arg 
    530                 535                 540                 


Lys Leu Leu Ala Val Leu Ser Asn Ala Glu Ser Ala Leu Ile Pro Leu 
545                 550                 555                 560 


Pro Arg Phe Ser Lys Met Leu Glu Arg Ala Gln Asn Ala Trp Arg Asp 
                565                 570                 575     


Gly Lys Asp Gly Leu Arg Leu Pro Lys Pro Ala Asn Arg Thr Asp Arg 
            580                 585                 590         


Glu Asn Pro Ala Arg Leu Cys Gln Tyr Ala Ala Leu Lys Leu Leu Tyr 
        595                 600                 605             


Glu Arg Ala Phe Arg Asn Trp Leu Tyr Glu Arg Ser Ala Glu Ser Leu 
    610                 615                 620                 


Asn Arg Phe Ile Asp Arg Ala Val Glu Arg Ala Thr Ala Ala Ala Arg 
625                 630                 635                 640 


Asp Leu Asn Ala Arg Asp Asp Glu Asp Arg Arg Asp Ile Ile Val Ala 
                645                 650                 655     


Lys Ala Ala Thr Leu Gly Arg Leu Ala Asp Gly Glu Thr Val Glu Thr 
            660                 665                 670         


Phe Phe Phe Lys Leu Ser Ala Gln Thr Ala Ser Glu Met Arg Val Gln 
        675                 680                 685             


Arg Gly Tyr Asp Ser Asp Ala Asp Arg Ala Arg Glu Gln Ala Gly Tyr 
    690                 695                 700                 


Ile Glu Asn Leu Lys Ser Asp Val Val Val Leu Ala Phe Gly Ala Tyr 
705                 710                 715                 720 


Leu Lys Glu Ala Ser Phe Asp Phe Leu Leu Lys Leu Ser Pro Asp Ala 
                725                 730                 735     


Pro Lys Pro Glu Lys Pro Leu Cys Ile Leu Asp Gly Met Arg Arg Asp 
            740                 745                 750         


Glu Gly Asp Arg Pro Ala Glu Asn Trp Gln Met Thr Leu Tyr Phe Leu 
        755                 760                 765             


Ile His Leu Val Pro Val Asp Glu Ile Gly Lys Leu Leu His Gln Met 
    770                 775                 780                 


Arg Lys Trp Glu Ser Leu Ala Ala Lys Pro Val Met Ala Asp Pro Asp 
785                 790                 795                 800 


Arg Arg Gln Leu Asp Lys Ser Thr Ile Ala Asp Asn Val Arg Lys Val 
                805                 810                 815     


Gln Ser Val Leu Glu Leu Tyr Leu Asp Met His Asp Ala Lys Phe Asp 
            820                 825                 830         


Gly Glu Ala Ala Leu Ile Gly Thr Gly Ala Phe Lys Lys Leu Tyr Glu 
        835                 840                 845             


Pro Glu Asp Leu Phe Asp Arg Ile Phe Pro Arg Gln Phe Gly Ala Asp 
    850                 855                 860                 


Asp Asp Arg Arg Ile Pro Arg Arg Gly Leu Arg Glu Ile Met Arg Phe 
865                 870                 875                 880 


Gly His Leu Gln Val Leu Arg Pro Val Phe Gln Lys His Pro Ile Gln 
                885                 890                 895     


Leu Ala Lys Val Glu Lys Phe Phe Ala Ala Glu Glu Arg Gln Asp Glu 
            900                 905                 910         


Gly Lys Ser Val Ile Ala Arg Gln Gln Glu Arg Arg Glu Ile Leu His 
        915                 920                 925             


Glu Lys Trp Ala Arg Asn Lys Lys Gly Phe Ser Ala Asp Asp Arg Gln 
    930                 935                 940                 


Ala Tyr Glu Glu Ala Leu Ala Ala Val Ile Arg Tyr Arg His Leu Ala 
945                 950                 955                 960 


Ala His Val Thr Leu Thr Asp His Val Arg Leu His Arg Leu Leu Met 
                965                 970                 975     


Ile Val Leu Gly Arg Leu Val Asp Tyr Ser Gly Leu Trp Glu Arg Asp 
            980                 985                 990         


Leu Tyr Phe Val Ala Leu Ala Leu  Ile Tyr Glu Val Gly  Cys Arg Pro 
        995                 1000                 1005             


Glu Asp  Val Phe Glu Lys Glu  Gly Leu Glu Phe Leu  Lys Asn Gly 
    1010                 1015                 1020             


Arg Ile  Val Gly Ala Leu Arg  Lys Leu Lys Gln Thr  Ser Ala Ala 
    1025                 1030                 1035             


His Ala  Val Val Asp Arg Leu  Ser Arg His Phe Gly  Ala Val His 
    1040                 1045                 1050             


Gly Lys  Glu Asn Arg Ala Val  Glu Ile Arg Asn Gly  Phe Ala His 
    1055                 1060                 1065             


Phe Asp  Met Leu Arg Ser Thr  Asn Arg Pro Val Asp  Leu Thr Ala 
    1070                 1075                 1080             


Cys Val  Asn Asp Ala Arg Asn  Leu Met Ala Tyr Asp  Arg Lys Leu 
    1085                 1090                 1095             


Lys Asn  Ala Val Ser Gln Ser  Ile Ala Glu Phe Leu  Ser Arg Glu 
    1100                 1105                 1110             


Gly Leu  Val Ile Ala Trp Ala  Ile Thr Pro Asp His  Arg Leu Gly 
    1115                 1120                 1125             


Thr Ala  Thr Leu Glu Thr Arg  Gln Ala Arg His Leu  Gly Gly Ser 
    1130                 1135                 1140             


Ser Ile  Leu Glu Asp Leu His  Gly Asn Gly Phe Val  Gln Met Val 
    1145                 1150                 1155             


Ala Ala  Leu Phe Asp Arg Cys  Thr Pro Arg Arg Pro  Ser Gly Gly 
    1160                 1165                 1170             


Glu Asn  Gln Arg Gly Gly Lys  Ser Ala Pro Gly Lys  Ser Arg Ala 
    1175                 1180                 1185             


Met Gln  Asn His Glu Ser His  Arg Pro 
    1190                 1195         


<210>  1179
<211>  1184
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1179

Met Arg Val Ser Lys Val Lys Val Leu Gly Asn Glu Glu Thr Lys Gly 
1               5                   10                  15      


Arg Ile Val Leu Met His Arg Ser Pro Val Lys Gly Gln Leu Ile Tyr 
            20                  25                  30          


Ser Glu Asp Ala Gly Lys Arg Asp Arg Thr Glu Asp Ile Ile Pro Glu 
        35                  40                  45              


Gln Lys Leu Glu Ser Phe His Leu Ser Ile Leu Asn Lys Thr Phe Leu 
    50                  55                  60                  


Arg Lys Glu Phe Phe Lys Lys Glu Leu Lys His Glu Ala Lys Lys Asn 
65                  70                  75                  80  


Gly Leu Lys Gly Asp Ala Glu Asp Lys Tyr Ile Ser Glu Lys Leu Lys 
                85                  90                  95      


Glu Tyr His Ser Leu Leu Gln Phe Ile Asp Asp Val Leu Ser Val Lys 
            100                 105                 110         


Tyr Asn Glu Asn Arg Lys Ala Ile Lys Phe Pro Glu Tyr Leu Thr Arg 
        115                 120                 125             


Glu Met Ile Glu Ile Phe Leu Asn His Lys Phe Arg Lys Glu Val Thr 
    130                 135                 140                 


Tyr Thr Asn Lys Asn Gly Ala Ser Val Ser Phe Leu Leu Ser Thr Leu 
145                 150                 155                 160 


Ile Leu Asn Ala Ile Glu Lys His Ser Val Ile Glu Met Gln Pro Phe 
                165                 170                 175     


Val Asp Trp Arg Asn Trp Phe Val Glu Thr Lys Ser Lys Phe Leu Lys 
            180                 185                 190         


Lys Ser Ile Ile Asn Asn Cys Ile Pro Thr Asn Gly Gly Pro Ile Ser 
        195                 200                 205             


Arg Arg Arg Glu Thr Leu Met Lys Trp Arg Asp Asp Tyr Phe Thr Asn 
    210                 215                 220                 


Ala Glu Ile Asp Leu Ala Arg Leu His Lys Lys Phe Gly Thr Asp Thr 
225                 230                 235                 240 


Leu Met Ala Ser Leu Arg Glu Val Pro Gln Thr Glu Lys Ser Gly Asn 
                245                 250                 255     


Glu Tyr His Arg Leu Leu Lys Ser Cys Leu Gln Ser His Gln Lys Lys 
            260                 265                 270         


Leu Phe Gly Lys Arg Ala Glu Gly Tyr Asp Ile Asn Arg Ala Asp Asn 
        275                 280                 285             


Gln Leu Tyr Val Tyr Asn Thr Glu Val Val Lys Tyr Met Glu His Tyr 
    290                 295                 300                 


Phe Pro Val Lys Ser Ser Lys Arg Arg Asn Ser Thr Ala Glu Ile Lys 
305                 310                 315                 320 


Tyr Tyr Leu Gln Thr Asp Thr Ile Lys Cys Cys Leu His His Gln Ile 
                325                 330                 335     


Ile Asn Ala Val Arg Gly Leu Ala Leu Arg Glu Gly Lys Phe Asn Leu 
            340                 345                 350         


His Gly Phe Asp Asp Lys Leu Ile Pro Asn Glu Arg Asn Val Ser Ser 
        355                 360                 365             


Ser Ile Leu Asn Glu Leu Lys Thr Ser Glu Gly Phe Val Leu Asn Met 
    370                 375                 380                 


Leu Gly Gly Cys Ala Phe Ala Ala Asn Cys Leu Arg Asn Ile Val Asp 
385                 390                 395                 400 


Ala Thr Gln Arg Ser Asp Leu Leu Gly Phe Arg Cys Phe Glu Val Ser 
                405                 410                 415     


Leu Lys Lys Gly Lys Ser Asn Ser Asp Leu Phe Ala Leu Phe Phe Gly 
            420                 425                 430         


Phe Gly Arg Glu Asp Met Asp Asp Asp Ser Glu Trp Glu Lys His Leu 
        435                 440                 445             


Tyr Ala Ala Arg Tyr Ser Val Ser Glu Ile Arg Asn Arg Val Ala His 
    450                 455                 460                 


Tyr His Lys Ser Ala Ile Glu Asn Ile Tyr Asn Ile Thr Asp Phe Glu 
465                 470                 475                 480 


Tyr Arg Glu Asn Ser Met Cys Ser Tyr Thr Asp Thr Lys Phe Thr Thr 
                485                 490                 495     


Ala Leu Gln Asn Glu Ile Tyr Asn Thr Pro Lys Ala Phe Ser Leu Gln 
            500                 505                 510         


Leu Met Thr Gly Lys Val Leu Glu Tyr Tyr Pro Lys Glu Lys Leu Val 
        515                 520                 525             


Ser Phe Phe Gln Lys Tyr Lys Phe Ser Leu Tyr Arg Ser Val Val Pro 
    530                 535                 540                 


Phe Ala Pro Gly Phe Lys Asn Ile Met Arg Thr Gly Val Asn Tyr Gln 
545                 550                 555                 560 


Asn Ala Thr Gln Asn Arg Leu Phe Tyr Asp Met Gly Leu Thr Ala Phe 
                565                 570                 575     


Gln Asp Lys Asp Arg Tyr Ile Asp Asp Val Glu Ala Trp Asn Ala Arg 
            580                 585                 590         


Tyr Phe Phe Met Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Arg Phe 
        595                 600                 605             


Thr Asn Asp Lys Asn Asp Leu Phe Arg Lys Thr Val Glu Gln Val Leu 
    610                 615                 620                 


Glu Val Asn Arg Ser His Met Glu Lys Val Gly Lys Asp Asp Arg Gln 
625                 630                 635                 640 


Ala Phe Gly Glu Val Arg Gln Met Arg Glu Asn Glu Thr Ala Asn Asp 
                645                 650                 655     


Tyr Met Ala Tyr Leu Gln Ser Ser Leu Arg Met Glu Lys Asn Lys Lys 
            660                 665                 670         


Glu Leu Glu Gly Asn Gly Ala Lys Arg Ile Asn Phe Glu Lys Phe Ile 
        675                 680                 685             


Leu Gln Met Phe Val Lys Gly Phe Asp Ser Phe Leu Lys Asp Gly Ala 
    690                 695                 700                 


Phe Glu Phe Val His Ser Pro Glu Asn Cys Leu Thr Gly Ser Thr Glu 
705                 710                 715                 720 


Lys Glu Arg Ala Lys Glu Arg Asn Ser Leu Cys Glu Glu Ile Gly Asn 
                725                 730                 735     


Tyr Val Arg Leu Val Ser Thr Val Ile Asp Pro Gly Lys Gly Ser His 
            740                 745                 750         


Val Ala Phe Tyr Val Phe Cys Lys Met Leu Asn Ser Val Tyr Leu Ser 
        755                 760                 765             


Asn Ile Arg Asn Glu Met Ile Lys Tyr His Lys Val Val Arg Thr Asp 
    770                 775                 780                 


Glu Leu Ala His Leu Ile Glu Ile Ile Glu Leu Cys Leu Leu Ser Ala 
785                 790                 795                 800 


Asp Ala Val Ser Gln Lys Thr Val Asn Ala Asp Lys Leu Ser His Phe 
                805                 810                 815     


Phe Ala Glu Gly Val Asn Val Asp Asp Asp Glu Asn Val Ile His Ala 
            820                 825                 830         


Ser Met Glu Thr Phe Arg Lys Tyr Gly Thr Arg Asp Leu Phe His Lys 
        835                 840                 845             


Leu Met Leu Gln Asp Asp Arg Phe Leu Val Ser Ser Asp Asp Tyr Arg 
    850                 855                 860                 


Glu Trp Glu Glu Met Lys Glu Lys Ile Glu Gly Lys Val Lys Gln Arg 
865                 870                 875                 880 


Glu Leu Leu His Ala Glu Trp Cys Glu Ala Lys Glu Lys Asp Lys Lys 
                885                 890                 895     


Ser Arg Lys Val Lys Ser Asn Ser Arg Thr Cys Phe Glu Lys Lys Phe 
            900                 905                 910         


Met Gly Ala Lys Ala Glu Glu Tyr Tyr Ser Leu Cys Asn Val Ile Asp 
        915                 920                 925             


Lys Tyr Asn Trp Leu Asp Asn Lys Leu His Leu Val His Leu Asn Lys 
    930                 935                 940                 


Leu His Asn Leu Val Ile Glu Ile Leu Gly Arg Met Val Gly Phe Thr 
945                 950                 955                 960 


Ala Leu Phe Glu Arg Asp Phe Gln Tyr Ile Cys Lys Ser Asp Ser Glu 
                965                 970                 975     


Tyr Glu Gln Leu Tyr Asn Leu Asp Phe Asn Met Gly Leu Pro Lys Phe 
            980                 985                 990         


Lys Asn Ser Ile Lys Gly Ser Gly  Lys Ala Lys Asn Ser  Thr Gln Asn 
        995                 1000                 1005             


Ile Asp  His Asn Ala Thr Gly  Ile Gly Asn Ser Ser  Asn Leu Leu 
    1010                 1015                 1020             


Lys Glu  Asn Ser Asn Gly Thr  His Tyr Cys Lys Asn  Leu Ser Gly 
    1025                 1030                 1035             


Asp Gly  Val Glu Asp Lys Leu  Lys Arg Leu Phe Leu  Tyr Asp Asp 
    1040                 1045                 1050             


Tyr Arg  Asn Val Arg Asn Phe  Val Ala His Phe Asn  Tyr Leu Thr 
    1055                 1060                 1065             


Arg Val  Glu Asp Asp Leu Gly  Gly Asn Asp Ala Val  Lys Leu Ser 
    1070                 1075                 1080             


Gly Thr  Arg Tyr Ser Leu Ile  Glu Leu Ile Asn Glu  Leu Arg Asn 
    1085                 1090                 1095             


Leu Leu  Lys Tyr Asp Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ser 
    1100                 1105                 1110             


Phe Ile  Asp Met Phe Glu Arg  His Gly Met His Val  Lys Met Lys 
    1115                 1120                 1125             


Leu Asn  His Asn His Lys Leu  Phe Val Asp Ser Ile  Ser Pro Arg 
    1130                 1135                 1140             


Lys Ile  Lys His Leu Gly Gly  Gly Tyr Lys Lys Arg  Gly Lys Asp 
    1145                 1150                 1155             


Asp Lys  Met Tyr Val Gln Thr  Thr Asn His Val Asp  Pro Leu Tyr 
    1160                 1165                 1170             


Cys Asp  Met Cys Arg Ala Leu  Leu Glu Met Lys 
    1175                 1180                 


<210>  1180
<211>  1105
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1180

Met Glu Lys Asp Asn Asn Leu Ile Met Leu Gly Tyr Lys Leu Lys Lys 
1               5                   10                  15      


Asn Ile Lys Glu Asp Glu Tyr Pro Tyr Leu Tyr Lys Asn Lys Asn Lys 
            20                  25                  30          


Gln Lys Ser Thr Pro Leu Tyr Thr Leu Leu Lys Lys Leu Ile Glu Lys 
        35                  40                  45              


Asn Lys Asn Ser Asn Gln Asn Ile Arg Glu Ser Glu Glu Tyr Glu Lys 
    50                  55                  60                  


Ile Gln Lys Asp Phe Lys Glu Tyr Lys Asn Ile Lys Ile Asn Leu Leu 
65                  70                  75                  80  


Val Lys Ser Ile Leu Asn Asn Lys Val Asn Ile Lys Tyr Asn Thr Ser 
                85                  90                  95      


Asn Asn Asn Ile Glu Glu Ser Asn Ser Lys Arg Glu Lys Glu Ile Ile 
            100                 105                 110         


Glu Phe Phe Lys Lys Met Ile Glu Glu Lys Asn Lys Ser Ile Leu Lys 
        115                 120                 125             


Asp Lys Leu Lys Leu Phe Arg Leu Glu Val Phe Phe Asp Glu Glu Phe 
    130                 135                 140                 


Leu Glu Glu Ile Lys Lys Leu Leu Asp Asn Asp Asn Leu Asp Lys Ser 
145                 150                 155                 160 


Asp Asn Lys Lys Ile Ala Glu Leu Arg Gly Lys Ile Phe Ser Arg Ile 
                165                 170                 175     


Arg Glu Lys Ile Lys Glu Asp Lys Asn Arg Asp Ile Leu Lys Asn Ile 
            180                 185                 190         


Tyr Phe Leu Glu Leu Lys Lys Tyr Ile Glu Asn Asn Leu Ser His Lys 
        195                 200                 205             


Lys Glu Asn Asn Lys Lys Asn Asn Asn Ile Gly Glu Glu Lys Ser Lys 
    210                 215                 220                 


Glu Leu Tyr Leu Lys Phe Leu Lys Lys Val Leu Phe Ile Asp Asp Asn 
225                 230                 235                 240 


Asn Arg Ile Ser Ile Glu Lys Leu Lys Ser Arg Ile Asp Asp Asn Phe 
                245                 250                 255     


Lys Asn Leu Leu Ile Gln His Val Ile Glu Tyr Gly Lys Ile Lys Tyr 
            260                 265                 270         


Tyr Val Glu Asn Asp Asp Tyr Ile Lys Asn Ile Val Lys Asn Gly Glu 
        275                 280                 285             


Leu Lys Leu Glu Thr Glu Asn Leu Glu Tyr Ile Arg Val Arg Glu Thr 
    290                 295                 300                 


Leu Ile Arg Lys Met Ala Val Leu Val Ser Phe Ala Ala Asn Ser Phe 
305                 310                 315                 320 


Tyr Asn Leu Phe Glu Asn Ile Thr Ser Asp Ile Leu Thr Ala Asn Ile 
                325                 330                 335     


Asn Leu Asp Ser Asp Val Ile Lys Ile Gly Asn Asn Arg Leu Lys Glu 
            340                 345                 350         


Lys Phe Leu Asn Tyr Phe Phe Tyr Ser Glu Glu Ile Ser Asp Lys Glu 
        355                 360                 365             


Asp Phe Leu Lys Ala Leu Lys Asp Ser Ile Tyr Asn Val Arg Asn Gly 
    370                 375                 380                 


Val Asn His Phe Asp Lys Met Ile Leu Gly Lys Tyr Asn Asn Arg Leu 
385                 390                 395                 400 


Asp Leu Lys Asp Ser Asn Thr Ile Lys Asp Tyr Phe Asn Phe Lys Lys 
                405                 410                 415     


Lys Glu Ile Lys Gln Asp Leu Lys Asp Arg Phe Ile Ser Asn Asn Leu 
            420                 425                 430         


Gln Tyr Tyr Tyr Thr Glu Asn Glu Ile Lys Lys Tyr Phe Glu Lys Tyr 
        435                 440                 445             


Lys Phe Glu Ile Leu Lys Thr Lys Ala Ser Phe Ala Pro Asn Phe Lys 
    450                 455                 460                 


Arg Ile Leu Arg Lys Gly Glu Asn Leu Ser Ile Ser Glu Ile Ser Asp 
465                 470                 475                 480 


Ile Tyr Asp Phe Phe Lys Arg Tyr Ser Glu Asn Ser Asp Lys Ser Ser 
                485                 490                 495     


Glu Tyr Asn Glu Phe Thr Lys Thr Arg Asn Phe Leu Leu Lys Glu Leu 
            500                 505                 510         


Tyr Tyr Asn Asn Phe Tyr Arg Glu Phe Leu Ser Asp Arg Thr Lys Phe 
        515                 520                 525             


Glu Glu Ala Val Lys Lys Val Lys Asn Asn Lys Lys Asn Arg Ile Ile 
    530                 535                 540                 


Asp Asn Arg Lys Ser Ala Gly Lys Ser Tyr Asp Val Ile Glu Asp Tyr 
545                 550                 555                 560 


Asn Ser Ser Asp Asp Val Leu Glu Tyr Ile Ser Arg Ile His Lys Ser 
                565                 570                 575     


Glu Met Glu Arg Ile Glu Val Asn Thr Glu Lys Asn Arg Lys Asp Thr 
            580                 585                 590         


Ser Lys Tyr Ile Arg Asp Phe Ile Glu Glu Val Phe Leu Glu Gly Phe 
        595                 600                 605             


Ile Lys Tyr Leu Asp Asn Asn Asn Phe Asn Phe Leu Lys Asn Arg Asn 
    610                 615                 620                 


Lys Ala Asp Lys Glu Arg Lys Glu Ile Val Arg Asn Leu Asn Ile Lys 
625                 630                 635                 640 


Ile Glu Gly Leu Asp Ile Leu Asn Gln Asn Asp Ser Glu Ile Leu Asn 
                645                 650                 655     


Leu Tyr Leu Phe Phe Asn Met Ile Asp Asn Lys Arg Ile Ser Glu Phe 
            660                 665                 670         


Arg Asn Glu Met Ile Lys Tyr Lys Gln Phe Leu Thr Lys Arg Gln Asn 
        675                 680                 685             


Ile Lys Ser Lys Phe Leu Glu Ile Asp Ile Glu Lys Ile Glu Ala Ile 
    690                 695                 700                 


Ile Glu Phe Val Ile Ile Thr Arg Gly Lys Leu Glu Ile Leu Glu Gly 
705                 710                 715                 720 


Glu Thr Lys Glu Gln Lys Lys Asp Asn Met Asn Ala Leu Phe Asn Lys 
                725                 730                 735     


Phe Tyr Ser Ser Glu Ser Glu Tyr Asp Glu Ser Leu Lys Lys Phe Ile 
            740                 745                 750         


Glu Glu Thr Val Leu Asn Asp Lys Lys Asn Thr Pro Phe Tyr Ser Thr 
        755                 760                 765             


Asp Gly Lys Thr Pro Ile Val His Ser Asn Leu Glu Lys Met Arg Lys 
    770                 775                 780                 


Tyr Gly Thr Glu Asn Phe Leu Ser Lys Val Leu Lys Asp Glu Lys Tyr 
785                 790                 795                 800 


Thr Leu Asp Asn Met Lys Ile Lys Glu Lys Phe Glu Thr Lys Val Asn 
                805                 810                 815     


Asp Lys Phe Lys Glu Gln Lys Ile Leu Glu Lys Val Asp Lys Ile Lys 
            820                 825                 830         


Gly Asn Glu Lys His Lys Lys Leu Ile Glu Tyr Tyr Asn Asp Cys Arg 
        835                 840                 845             


Cys Tyr Leu His Gly Glu Trp Ile Glu Asn Lys Lys Asn Lys Glu Glu 
    850                 855                 860                 


Phe Glu Tyr Lys Glu Ile Tyr Glu Lys Ile Ile Glu Glu Ile Arg Lys 
865                 870                 875                 880 


Tyr Asn Tyr Leu Glu Asn Lys Glu Lys Leu Gln Asn Val Tyr Leu Leu 
                885                 890                 895     


His Glu Ile Thr Ser Asp Leu Met Ala Arg Asn Val Ala Phe Ile Asn 
            900                 905                 910         


Lys Trp Glu Arg Asp Phe Lys Phe Leu Ser Ile Ala Ile Lys Glu Asn 
        915                 920                 925             


Leu Lys Asp Ser Asn Asp Ile Gln Lys Ile Glu Glu Phe Leu Asn Pro 
    930                 935                 940                 


Ser Leu Asp Thr Thr Ser Asp Glu Glu His Phe Asn Val Lys Asn Tyr 
945                 950                 955                 960 


Ala Ser Lys Leu Lys Asn Ile Gln Gly Leu His Asn Asn Ile Ile Ser 
                965                 970                 975     


Leu Ile Phe Ile Lys Asn Leu Asp Gly Trp Asn Asn Lys Ile Asp Asn 
            980                 985                 990         


Phe Lys Trp Leu Gly Phe Arg Asn  Tyr Ile Ser His Phe  Asn His Ile 
        995                 1000                 1005             


Asn Gly  Glu Asn Ser Lys Glu  Ser Phe Ile Asn Gln  Leu Asn Arg 
    1010                 1015                 1020             


Leu Val  Leu Leu Phe Ser Tyr  Asp Lys Lys Val Gln  Asn His Ile 
    1025                 1030                 1035             


Thr Lys  Ser Ile Lys Thr Ile  Leu Glu Lys Tyr Asn  Ile Asp Ile 
    1040                 1045                 1050             


Glu Phe  Lys Ile Ser Asp Asp  Ser Lys Asn Phe Phe  Glu Tyr Gln 
    1055                 1060                 1065             


Ile Ser  Asn Ile Asn Ser Lys  Lys Gly Lys Met Leu  Gly Lys Glu 
    1070                 1075                 1080             


Asn Tyr  Phe Glu Leu Leu Asp  Lys Glu Phe Val Gln  Asn Val Lys 
    1085                 1090                 1095             


Lys Met  Leu Glu Tyr Glu Asp  
    1100                 1105 


<210>  1181
<211>  1228
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1181

Met Lys Val Ser Lys Val Asn His Arg Arg Ala Ala Val Ala Val Asn 
1               5                   10                  15      


Lys Lys Ser Val Thr Val Asn Gly Ile Leu Tyr Asp Ala Pro Val Lys 
            20                  25                  30          


Lys Asn Val Lys Thr Gly Asn Met Ser Ala Tyr Val Ser Ser Lys Tyr 
        35                  40                  45              


Val Ile Asp Asn Val Val Lys Asn Ser Ser Arg Leu Tyr Ser Pro Phe 
    50                  55                  60                  


Ser Ser Lys Arg Ile Val Ile Asp Arg Glu Lys Ile Arg Ile Ala Asp 
65                  70                  75                  80  


Arg Leu Lys Gln Cys Tyr Val Asn Phe Val Lys Tyr Tyr Leu Ser Asn 
                85                  90                  95      


Gly Ser Leu Asn Glu Gln Gln Met Arg Phe Asn Pro Asn Asn Thr Tyr 
            100                 105                 110         


Met Ala Asp Ser Arg Val His Phe Cys Val Pro Ser Gly Ile Asp Ile 
        115                 120                 125             


Glu Ser Leu Ile Asn Ser Ile Val Asp Ser Ser Leu Arg Lys Ser Leu 
    130                 135                 140                 


Lys Arg Thr Tyr Arg Phe Glu Thr Asn Tyr Gly Glu Lys Asn Thr Phe 
145                 150                 155                 160 


Asn Leu Pro Asp Leu Val Lys Lys Ser Ile Lys Ile Tyr Cys Thr Asp 
                165                 170                 175     


Glu Lys Arg Lys Leu Asn Asp Arg Glu Glu Gln Glu Met Tyr Val Leu 
            180                 185                 190         


Phe Ser Tyr Met Tyr Glu Asp Lys Tyr Lys Asp Arg Gln Lys Val Leu 
        195                 200                 205             


Ile Ala Asn Ser Ile Ser Asn Gln Ala Thr Lys Val Lys Val Cys Asp 
    210                 215                 220                 


Asp Glu Ser Arg Leu Ile Lys Leu Ser Ile Ala Asp Thr Lys Lys Lys 
225                 230                 235                 240 


Pro Leu Trp Asp Phe Ile Val Asp Tyr Ala Asn Ser Asp Lys Asn Gly 
                245                 250                 255     


Gln Tyr Thr Ile Leu Arg Asn Ile Arg Lys Ser Ile Val Leu Phe Val 
            260                 265                 270         


Cys Gly Val Asp Val Tyr Arg Asn Ile Glu Asn Asn Asp Asn Leu Asp 
        275                 280                 285             


Ile Trp Lys Trp Glu Glu Tyr Gly Ile Gln Glu Ser Gln Leu Phe Val 
    290                 295                 300                 


Lys Ile Glu Asn Cys Tyr Thr Thr Lys Gly Glu Asp Ile Ala Leu Asn 
305                 310                 315                 320 


Glu Ile Arg Asn Val Asn Leu Asp His Tyr Met Lys Ala Ile Gly Val 
                325                 330                 335     


Leu Asp Asp Glu Arg Ser Lys Phe Trp Phe Gln His Tyr Glu Asn Thr 
            340                 345                 350         


Ile Glu Ala Leu Phe Ser Lys Lys Ser Lys Arg Lys Ile Glu Arg Ile 
        355                 360                 365             


Lys Thr Ala Tyr Leu Cys Glu Tyr Leu Trp Lys Asn Phe Cys Ser Tyr 
    370                 375                 380                 


Val Ala Leu Lys Tyr Val Asp Leu Gly Lys Gly Val Tyr His Phe Thr 
385                 390                 395                 400 


Met Ser Asp Lys Leu Ser Leu Met Asn Lys Asn Thr Asn Glu Asn Gly 
                405                 410                 415     


Ile Lys Phe Gly Glu Val Asp Ser Arg Phe Asn Lys Gly Ile Ser Ser 
            420                 425                 430         


Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Thr Ile Asp Arg Asn Ile 
        435                 440                 445             


Ser Thr Tyr Thr Thr Phe Ala Thr Asn Ile Phe Ala Lys Ser Val Ile 
    450                 455                 460                 


Lys Asp Ser Tyr Arg Gln Lys Lys Ala Gly Asn Ser Asp Ala Leu Gln 
465                 470                 475                 480 


Tyr Asp Asp Glu Thr Tyr Lys Asn Arg Leu Ser Lys Ile Arg Asn Ser 
                485                 490                 495     


Gly Val His Tyr Thr Ser Thr Ser Ala Leu Lys Gly Asn Asp Asp Asp 
            500                 505                 510         


Ser Ile Val Gly Met Leu Ile Lys Lys Asp Phe Asp Asp Ile Lys Asp 
        515                 520                 525             


Val Tyr Ala Ser Lys Tyr Tyr Ser Asn Asn Val Trp Met Phe Tyr Asn 
    530                 535                 540                 


Thr Asp Lys Ile Ser Lys Met Met Glu Tyr Leu Tyr Gln Asp Asp Ser 
545                 550                 555                 560 


Asn Ile Arg Asp Ala Gln Ile Pro Ala Phe Asn Ser Val Ile Lys Arg 
                565                 570                 575     


Lys Asp Met Ala Glu Val Ile Glu Lys Ile Val Lys Lys Asn Ser Tyr 
            580                 585                 590         


Lys Thr Ile Lys Glu Pro Tyr Gln Arg Glu Lys Tyr Arg Ser Cys Leu 
        595                 600                 605             


Tyr Phe Met Leu Lys Glu Ile Tyr Tyr Asn Arg Phe Ile Lys Gln Asp 
    610                 615                 620                 


Asn Leu Lys Asp Gln Val Ile Gln Ile Ile Asp Ser Asn Thr Glu Leu 
625                 630                 635                 640 


Ile Gly Asp Asn Ser Arg Ala Val Asp Asn Leu Lys Lys Arg Ile His 
                645                 650                 655     


Asp Val Asp Ser Gln Thr Met Ser Phe Gly Glu Leu Cys Gln Val Ile 
            660                 665                 670         


Met Thr Asp Tyr Asn Met Gln Asn Gln Glu Asn Lys Ser Ile Lys Ser 
        675                 680                 685             


Lys Glu Arg Gln Asp Lys Asp Arg Lys Asn Gly Ile Asp Asn Ser Tyr 
    690                 695                 700                 


Lys His Phe Pro Leu Leu Leu His His Leu Ile Lys Val Ser Phe Leu 
705                 710                 715                 720 


Lys Phe Ile Lys Thr Asp Glu Lys Leu Ala Phe Ile Arg Glu Pro Arg 
                725                 730                 735     


Ile Thr Glu Trp Asp Lys Thr Leu Glu Gln Phe Glu Ala Gln Ile Gln 
            740                 745                 750         


Thr Val Asp Ile Tyr Asn Ser Leu Lys Met Met Val Ala Glu Asn Lys 
        755                 760                 765             


Ser Leu Leu Asp Trp Tyr Thr Leu Ala His Phe Leu Met Pro Lys Gln 
    770                 775                 780                 


Leu Asn His Leu Ile Gly Asp Val Lys Asn Tyr Ile Gln Tyr Leu Ser 
785                 790                 795                 800 


Asn Ile Asp Lys Arg Ala Gly Ser Val Lys Asn Asn Lys Ser Ala Ser 
                805                 810                 815     


Thr Glu Val Lys Ile Arg Gln Tyr Ser Glu Ile Val Arg Ile Leu Asp 
            820                 825                 830         


Phe Ser Leu Gln Tyr Ile Gly Arg Val Ser Asn Asp Val Thr Asp Tyr 
        835                 840                 845             


Phe Val Asp Glu Asp Glu Tyr Ala Ala Phe Leu Ser Lys Tyr Val Glu 
    850                 855                 860                 


Phe Ser Gly Asn Asp Ile Val Ser Met Lys Ala Phe Cys Gln Ser Arg 
865                 870                 875                 880 


Thr Ala Asn Gly Lys His Thr Ile Gly Leu Tyr Cys Asp Gly Ala Asn 
                885                 890                 895     


Pro Ile Met Asn Arg Asn Ile Ala Tyr Ala Lys Met Tyr Gly Asn Asp 
            900                 905                 910         


Glu Ile Leu Ser Tyr Ile Tyr Asn Lys Val Thr Lys Lys Asp Ile Glu 
        915                 920                 925             


Lys Tyr Tyr Val Ser Gln Asp Asn Leu Glu Lys Val Phe Ala Asp Gly 
    930                 935                 940                 


Lys Cys Gln Asp Val Gln Gln Gln Asn Ala Leu Cys Asp Phe Gln Lys 
945                 950                 955                 960 


Met Lys Asn His Ile Glu Leu Thr Glu Val Ser Ile Tyr Thr Asp Ile 
                965                 970                 975     


Leu Asn Asp Phe Met Ala Gln Phe Ile Ser Trp Ala Tyr Leu Arg Glu 
            980                 985                 990         


Arg Asp Leu Met Tyr Phe Gln Leu  Gly Leu Asn Tyr Ile  Arg Met Phe 
        995                 1000                 1005             


Tyr Gly  Thr Tyr Glu Leu Glu  Glu Lys Tyr Tyr Lys  Leu His Gly 
    1010                 1015                 1020             


Glu Asn  Ile Asn Ile Glu Lys  Gly Ala Leu Leu Tyr  Gln Ile Val 
    1025                 1030                 1035             


Ala Met  Tyr Ser His Glu Leu  Pro Ile Tyr Lys Val  Asp Glu Ser 
    1040                 1045                 1050             


Gly Ile  Ala Ile Leu Ala Glu  Lys Gln Gly Ser Ser  Gly Ala Ser 
    1055                 1060                 1065             


Ile Lys  Ser Phe Val Thr Glu  Tyr Cys Lys Glu Glu  Met Lys Lys 
    1070                 1075                 1080             


Ala Tyr  Thr Tyr Glu Asn Gly  Leu Glu Leu Phe Glu  Asp Val Asn 
    1085                 1090                 1095             


Gln His  Asp Asp Leu Ser Lys  Leu Arg Asn Asp Phe  Ala His Met 
    1100                 1105                 1110             


Arg Tyr  Met Ser Ala Arg Asp  Lys Ser Ile Met Asp  Ile Val Ser 
    1115                 1120                 1125             


Glu Ile  Tyr Asn Gly Phe Phe  Ile Tyr Asp Thr Lys  Leu Lys Lys 
    1130                 1135                 1140             


Ser Val  Ser Phe Ile Phe Lys  Asn Ile Leu Met Arg  Tyr Ala Val 
    1145                 1150                 1155             


Asp Val  Asn Ile Glu Phe Cys  His Lys Gly Asp Asn  Glu Asp Thr 
    1160                 1165                 1170             


Asn Asn  Leu Ile Arg Ile Lys  Asp Glu Val Gly Leu  Tyr Ser Asp 
    1175                 1180                 1185             


Lys Tyr  Thr Tyr Lys Val Glu  Asp Asn Asp Thr Val  Asp Ile Glu 
    1190                 1195                 1200             


Val Arg  Asn Ser Glu Phe Leu  Glu Gln Leu Lys Lys  Leu Leu Glu 
    1205                 1210                 1215             


Tyr Lys  Lys Glu Ser Glu Gly  Ser Glu Leu 
    1220                 1225             


<210>  1182
<211>  1237
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1182

Leu Lys Trp Asp Lys Leu Arg Ser Lys Arg Thr Tyr Phe Arg Cys Glu 
1               5                   10                  15      


Trp Gly Asn Ile Ala Pro Met Asp His Leu Tyr Val Trp Lys Pro Pro 
            20                  25                  30          


Trp Tyr Cys Leu Gln Leu Thr Thr Ala Phe Ile Leu Ser Leu Ser Val 
        35                  40                  45              


Arg Phe Leu Met Lys Tyr Val Lys Pro Tyr Gly Arg Ser Lys Thr Val 
    50                  55                  60                  


Leu Val Glu Gly Lys Lys Thr Arg Leu Leu Ser Arg Arg Lys Lys Gly 
65                  70                  75                  80  


Asn Glu Val Glu Thr Ser Ser Phe Asp Ala Phe Tyr Ala Ser Asp Pro 
                85                  90                  95      


Ser Phe Val Leu Ser Arg Leu Ile Ser Glu Phe Asp Lys Val Ala Ala 
            100                 105                 110         


Lys Pro Arg Gln Gly Glu Leu Pro Ser Lys Arg Gln Phe Gln Phe Arg 
        115                 120                 125             


Ser Asp Leu Gly Ala Glu Ile Trp Glu His Phe Lys Leu Lys Pro Trp 
    130                 135                 140                 


Phe Thr Asp Lys Pro Glu Tyr Trp Ala Lys Leu Trp Lys Thr Lys Leu 
145                 150                 155                 160 


His Pro Tyr Gly Arg Glu Val Lys Asp Asp Pro Lys Thr Ala Pro Asn 
                165                 170                 175     


Arg Arg Pro Ala Lys Asp Glu Arg Gln Gly Arg Leu Tyr Lys Lys Tyr 
            180                 185                 190         


Phe Gly Ile Thr Pro Pro Asp Gln Ile Asn Ala Ala Ser Leu Pro Ser 
        195                 200                 205             


Met Ile Glu Gln Glu Leu Phe Val His Gly Thr Thr Gly Ala Gly Asp 
    210                 215                 220                 


Thr Pro Gly Gly Gly Val Gly Gln Arg Gly Lys Ile Thr Gln His Ala 
225                 230                 235                 240 


Arg Thr Leu Ser Ser Asn Ala His Ser Leu Glu Arg Val Lys Gly Thr 
                245                 250                 255     


Ala Ala Pro Trp Glu Ala Met Asp Leu Glu Asp Tyr Lys Asn Tyr Gly 
            260                 265                 270         


Asp Val Ala Gly Glu Ile Ile Gln Ala Leu Lys Val Lys Lys Glu Lys 
        275                 280                 285             


Pro Lys Ser Gly Arg Ser Ala Lys Pro Phe Thr Pro Ser Pro Ala Phe 
    290                 295                 300                 


Phe Ala Ser Ile Leu His Asp His Tyr Ala Arg Val Phe Gln Arg Asp 
305                 310                 315                 320 


Glu Val Arg Pro Gly Ser Asn Gln Glu Pro Met Ser Ile Lys Glu Val 
                325                 330                 335     


Lys Gln Asn Ala Ala Tyr Thr Gly Leu Phe Glu Leu His Glu Ala Ile 
            340                 345                 350         


Cys Asp Phe Tyr Lys Asn Ala Ala Arg Ser Arg Asn Arg Gln Leu Asp 
        355                 360                 365             


Ser Met Ile Val Ala Leu Pro Lys Asn Met Asp Asp Leu Phe Lys Arg 
    370                 375                 380                 


Leu Arg Met Arg Arg Val Asn Gln Ser Leu Asn Ser Met Ile Arg Leu 
385                 390                 395                 400 


Gly Lys Val Ile His Tyr Ser Ala Ala Ser Ser Glu Asp Glu Asp Ser 
                405                 410                 415     


Pro Arg Asp Val Val Lys Asn Trp Pro Ser Asp Ile Asp Asn Ser Pro 
            420                 425                 430         


Tyr Trp Leu Ser Glu Gly Met Ala Lys Ile Lys Arg Asn Glu Ala Phe 
        435                 440                 445             


Val Arg Val Trp Arg Thr Ala Ile Ser His Ala Ala His Gly Leu Arg 
    450                 455                 460                 


Thr Trp Val Ala Ile Asp Gly His Glu Val Asp Gly Leu Pro Val Asp 
465                 470                 475                 480 


Leu Leu Leu Gln Asp Gly Arg Glu Phe Ile Ser Asp Phe Phe Glu Asn 
                485                 490                 495     


Glu Leu Phe Gln Lys Gln Ala Gly Phe Tyr Phe Gly Asp Arg Ala Lys 
            500                 505                 510         


His Phe Gly Thr Asn Ala Asp Glu Arg Glu Ala Gly Leu Lys Leu Met 
        515                 520                 525             


Ala Phe Thr Leu Ser Arg Tyr Arg Asn Ser Gly Phe His Phe Asn Gly 
    530                 535                 540                 


Arg Gly Gly Phe Val Arg Met Leu Lys Pro Gln Glu Asp Gln Asn Tyr 
545                 550                 555                 560 


Gln Gly Ser Asp Val Phe Leu Asn Ile Leu Asn Glu Asp Val Ala Arg 
                565                 570                 575     


Leu Glu Glu Arg Asn Lys Glu Val Leu Arg Ala Val Gln Ile Lys Thr 
            580                 585                 590         


Phe Thr Lys Gln His Glu Leu Asp Lys Ile Tyr Glu Glu Ile Ser Gln 
        595                 600                 605             


Gly Arg Gly Ser Gly Thr Leu Ala Pro Arg Phe Asn Arg Val Leu Gln 
    610                 615                 620                 


Arg Val Lys Asn Ala Trp Thr Lys Glu Lys Leu Pro Lys Asp Ile Asp 
625                 630                 635                 640 


Thr Lys Thr Ala Leu Arg Leu Pro Asp Pro Arg Asn His Ile Asp Leu 
                645                 650                 655     


Lys Asn Pro Val Leu Lys Ala Gln Tyr Leu Ala Leu Lys Leu Val Tyr 
            660                 665                 670         


Glu Thr Gly Phe Arg His Trp Met Thr His Lys Val Gly Ala Asp Leu 
        675                 680                 685             


Thr Pro Trp Ile Asp Gln Ala Val Lys Arg Ala His Ala Ala Met Lys 
    690                 695                 700                 


Glu Leu Asn Asp Gln Asn Asp Glu Phe Glu Ile Val Thr Lys Ile Ala 
705                 710                 715                 720 


Gly Leu Val Glu Leu Gly Ala Glu Asp Ser Ile Glu Glu Phe His Asp 
                725                 730                 735     


Gln Leu Ala Glu Lys Ala Ala Ala Val Ser Pro Leu Gln Ser Asn Tyr 
            740                 745                 750         


Ser Asn Glu Gln Asp Lys Met Ser Arg Gln Ser Ser His Ile Asp Asp 
        755                 760                 765             


Leu Arg Thr Asp Val Phe Ala Ile Ala Phe Glu Asp Tyr Leu Lys Glu 
    770                 775                 780                 


Gln Gly Phe Glu Phe Leu Leu Thr Leu Pro Lys Glu Arg Asp Thr Gly 
785                 790                 795                 800 


Leu Gly Ala Gly Ala Ala Leu Ile Asp Asp Leu Pro Arg Val Asp Thr 
                805                 810                 815     


Asn Pro Val Gly Trp Asp Leu Tyr His Gly Arg Leu Tyr Ala Ile Leu 
            820                 825                 830         


His Leu Ile Pro Ala Gly Thr Val Asn Ala Leu Ala His Gln Leu Arg 
        835                 840                 845             


Lys Trp Glu Val Leu Asp Thr Arg Gly Glu Ala Leu His Leu Lys Thr 
    850                 855                 860                 


Leu Glu Thr Asn Pro Glu Glu Lys Asp Ala Thr Leu Arg Val Arg Glu 
865                 870                 875                 880 


Leu Leu Asp Leu Tyr Leu Thr Met Arg Asp Asp Lys Phe Thr Glu Gly 
                885                 890                 895     


Ala Trp Ile Asp Val Gly Glu Glu Leu Arg Glu Val Phe Asp Ser Glu 
            900                 905                 910         


Glu Thr Met Arg Arg Val Phe Pro Thr Ala Ser Ala Glu Thr Asp Glu 
        915                 920                 925             


His Ile Pro Ile Arg Gly Leu Arg Glu Leu Leu Arg Thr Gly Ser His 
    930                 935                 940                 


Glu Val Leu Gly Gln Ile Tyr Gln Lys His Lys Ile Thr Ser Arg Asp 
945                 950                 955                 960 


Leu Glu Lys Leu Gly Ala Phe Ser Lys Ser Asn Val Glu Asn Leu His 
                965                 970                 975     


Lys Ser Tyr Gly Asp Leu His Ala Asp Trp Val Glu Lys Lys Lys Glu 
            980                 985                 990         


Phe Lys Glu Ile Glu Lys Tyr Asn  Asp Ile Ala Gln Gln  Leu Asp Ala 
        995                 1000                 1005             


Tyr Arg  Ser Ile Arg Asn Phe  Val Gln Leu Asn Thr  His Leu Arg 
    1010                 1015                 1020             


Thr Tyr  Arg Leu Met Met Asp  Val Val Gly Arg Phe  Val Asp Leu 
    1025                 1030                 1035             


Ala Gly  Met Phe Glu Arg Asp  Val Tyr Phe Val Met  Leu Ala Leu 
    1040                 1045                 1050             


Ile Tyr  Arg Ala Gly Gly Asp  Ser Gln Asn Ala Leu  Glu Thr Val 
    1055                 1060                 1065             


Phe Glu  Asn Glu Gly Lys Gly  Met Leu Lys Ser Gly  Arg Val Phe 
    1070                 1075                 1080             


Ala Ala  Cys Ser His Phe Leu  Glu Pro Glu Asp Lys  Gln His Val 
    1085                 1090                 1095             


Val Leu  Thr Arg Leu Glu Ile  Phe Phe Gly Lys Lys  Phe Trp Asp 
    1100                 1105                 1110             


Ser Gly  Gln Pro Glu Ser Glu  Val Gly Gln Val Asn  Arg Arg Pro 
    1115                 1120                 1125             


Val Lys  Ala Arg Asn Asp Phe  Ala His Phe Asn Val  Leu Leu Val 
    1130                 1135                 1140             


Gln Glu  Asn Asn Lys Phe Lys  Thr Pro Asn Leu Thr  His Leu Met 
    1145                 1150                 1155             


Asn Arg  Ala Arg Asp Met Val  Ala Tyr Asp Arg Lys  Leu Arg Asn 
    1160                 1165                 1170             


Ser Leu  Ser Lys Ser Ile Ser  Asp Leu Leu Ala Lys  Ser Gly Leu 
    1175                 1180                 1185             


Gln Ile  Ser Trp Asn Thr Asp  Lys His Thr Leu Val  Asp Ala Lys 
    1190                 1195                 1200             


Val Ser  Ser Leu Glu Ile Asn  His Leu Gly Gly Met  Gly Arg Thr 
    1205                 1210                 1215             


Glu Lys  Leu Asn Asn Ala Gln  Phe Val Ala Met Val  Gly Glu Leu 
    1220                 1225                 1230             


Phe Ala  Pro Glu 
    1235         


<210>  1183
<211>  1385
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1183

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Pro Gly Thr Asp Thr 
            20                  25                  30          


Ile Asp Leu Asn Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Thr Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Asp Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Glu Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Gly Leu Phe Val Asn Ile 
                325                 330                 335     


Pro Asp Val Leu Met Lys Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Ile Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Ser Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg 
465                 470                 475                 480 


Asn Gly Ile Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Tyr Glu Asn 
                485                 490                 495     


Leu Gln Arg Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu 
            500                 505                 510         


Ala Arg Ala Val Cys Asp Met Ser Asn Leu Lys Asp Arg Glu Ser Asp 
        515                 520                 525             


Phe Leu Leu Trp Lys Lys Glu Asp Ile Ala Asp Lys Leu Lys Asn Lys 
    530                 535                 540                 


Asp Asp Met Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys 
545                 550                 555                 560 


Ser Ser Trp Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn 
                565                 570                 575     


Lys Tyr Asn Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile 
            580                 585                 590         


Tyr Cys Ala Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn 
        595                 600                 605             


Asn Glu Lys Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu 
    610                 615                 620                 


Thr Glu Phe Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn 
625                 630                 635                 640 


Leu Tyr Met Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Gln 
                645                 650                 655     


Leu Tyr Ser Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn 
            660                 665                 670         


Ser Val Phe Ile Arg Lys Asn Phe Pro Glu Asp Ile Thr Asn Val Leu 
        675                 680                 685             


Arg Tyr Gln Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr 
    690                 695                 700                 


Ser Ala Cys Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu 
705                 710                 715                 720 


Gln Ser Asp Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu 
                725                 730                 735     


Ser Trp Asp Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn 
            740                 745                 750         


His Phe Ser Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys 
        755                 760                 765             


Gln Ile Tyr Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys 
    770                 775                 780                 


Val Arg Ser Ser Asn Asp Ser Ile Phe Asp Lys Pro Ile Tyr His His 
785                 790                 795                 800 


Tyr Lys Val Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr 
                805                 810                 815     


Leu Lys Tyr Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys 
            820                 825                 830         


Ala Asn Glu Ile Arg Lys Ile Asp Lys Glu Arg Phe Leu Pro Asp Trp 
        835                 840                 845             


Thr Ser Thr Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln 
    850                 855                 860                 


Glu Leu Gln Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser 
865                 870                 875                 880 


Leu Asn Leu Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr 
                885                 890                 895     


Asp Ile Lys Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser 
            900                 905                 910         


Val Gln Asp Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val 
        915                 920                 925             


Cys Ser Leu Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe 
    930                 935                 940                 


Asn Asp Lys Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe 
945                 950                 955                 960 


Ser Asn Ala Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser 
                965                 970                 975     


Asn Glu Glu Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val 
            980                 985                 990         


Asn Arg Asn Ile Val His Ser Lys  Leu Phe Ala Ala Asp  His Ile Leu 
        995                 1000                 1005             


Arg Asp  Ile Val Glu Pro Val  Ser Lys Asp Asn Ile  Glu Glu Phe 
    1010                 1015                 1020             


Tyr Asp  Gln Lys Ala Glu Ile  Val Tyr Cys Lys Ile  Lys Gly Lys 
    1025                 1030                 1035             


Asp Ile  Thr Ala Glu Glu Gln  Lys Ala Val Leu Lys  Tyr Gln Lys 
    1040                 1045                 1050             


Leu Lys  Asn Arg Val Glu Leu  Arg Asp Ile Val Glu  Tyr Gly Glu 
    1055                 1060                 1065             


Ile Ile  Asn Glu Leu Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met 
    1070                 1075                 1080             


Arg Glu  Arg Asp Leu Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn 
    1085                 1090                 1095             


Cys Leu  Arg Asn Asn Ser Glu  Lys Lys Glu Ala Tyr  Gln Lys Ile 
    1100                 1105                 1110             


Glu Val  Asn Gly Asp Ser Ile  Lys Asp Ala Ile Leu  Tyr Gln Ile 
    1115                 1120                 1125             


Ile Gly  Met Tyr Val Asn Gly  Val Ala Val Tyr Ala  Pro Asp Glu 
    1130                 1135                 1140             


Lys Gly  Asp Ile Leu Lys Glu  Gln Cys Thr Lys Gly  Gly Ala Gly 
    1145                 1150                 1155             


Gly Lys  Ile Ser Ala Phe Asn  Arg Tyr Ser Glu Tyr  Leu Gly Leu 
    1160                 1165                 1170             


Asp Lys  Leu Thr Leu Tyr Asn  Ala Gly Leu Glu Ile  Phe Glu Val 
    1175                 1180                 1185             


Val Ala  Glu His Asp Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp 
    1190                 1195                 1200             


His Phe  Lys Tyr Tyr Leu Gly  Asp Tyr Arg Ser Met  Leu Ser Ile 
    1205                 1210                 1215             


Tyr Ser  Glu Val Phe Asp Arg  Phe Phe Thr Tyr Asp  Ile Lys Tyr 
    1220                 1225                 1230             


Gln Lys  Asn Val Leu Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His 
    1235                 1240                 1245             


Asn Val  Ile Val Glu Pro Val  Leu Glu Ser Gly Phe  Lys Thr Ile 
    1250                 1255                 1260             


Gly Lys  Gln Thr Thr Ser Gly  Ala Lys Leu Ser Ile  Arg Ser Ile 
    1265                 1270                 1275             


Lys Ser  Asp Thr Phe Gln Tyr  Lys Val Lys Gly Gly  Ser Leu Ile 
    1280                 1285                 1290             


Thr Asp  Ala Lys Asp Glu Arg  Tyr Leu Lys Thr Ile  Arg Lys Ile 
    1295                 1300                 1305             


Leu Tyr  Tyr Val Glu Asn Glu  Glu Asp Asn Leu Lys  Lys Ser Val 
    1310                 1315                 1320             


Val Val  Thr Asn Ala Asp Lys  Tyr Glu Lys Asn Lys  Glu Ser Asp 
    1325                 1330                 1335             


Asp Gln  Asn Lys Gln Lys Glu  Lys Lys Asn Lys Asp  Asn Lys Gly 
    1340                 1345                 1350             


Lys Lys  Asn Glu Glu Thr Lys  Ser Asp Ala Gly Lys  Asn Asn Asn 
    1355                 1360                 1365             


Glu Arg  Leu Ser Tyr Asn Pro  Phe Ala Asn Leu Asn  Phe Lys Leu 
    1370                 1375                 1380             


Pro Asn  
    1385 


<210>  1184
<211>  1385
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1184

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Pro Gly Thr Asp Thr 
            20                  25                  30          


Ile Asp Leu Asn Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Thr Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Asp Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Glu Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Gly Leu Phe Val Asn Ile 
                325                 330                 335     


Pro Asp Val Leu Met Lys Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Ile Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Ser Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg 
465                 470                 475                 480 


Asn Gly Ile Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Tyr Glu Asn 
                485                 490                 495     


Leu Gln Arg Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu 
            500                 505                 510         


Ala Arg Ala Val Cys Asp Met Ser Asn Leu Lys Asp Arg Glu Ser Asp 
        515                 520                 525             


Phe Leu Leu Trp Lys Lys Glu Asp Ile Ala Asp Lys Leu Lys Asn Lys 
    530                 535                 540                 


Asp Asp Met Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys 
545                 550                 555                 560 


Ser Ser Trp Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn 
                565                 570                 575     


Lys Tyr Asn Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile 
            580                 585                 590         


Tyr Cys Ala Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn 
        595                 600                 605             


Asn Glu Lys Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu 
    610                 615                 620                 


Thr Glu Phe Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn 
625                 630                 635                 640 


Leu Tyr Met Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Gln 
                645                 650                 655     


Leu Tyr Ser Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn 
            660                 665                 670         


Ser Val Phe Ile Arg Lys Asn Phe Pro Glu Asp Ile Thr Asn Val Leu 
        675                 680                 685             


Arg Tyr Gln Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr 
    690                 695                 700                 


Ser Ala Cys Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu 
705                 710                 715                 720 


Gln Ser Asp Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu 
                725                 730                 735     


Ser Trp Asp Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn 
            740                 745                 750         


His Phe Ser Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys 
        755                 760                 765             


Gln Ile Tyr Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys 
    770                 775                 780                 


Val Arg Ser Ser Asn Asp Ser Ile Phe Asp Lys Pro Ile Tyr His His 
785                 790                 795                 800 


Tyr Lys Val Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr 
                805                 810                 815     


Leu Lys Tyr Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys 
            820                 825                 830         


Ala Asn Glu Ile Arg Lys Ile Asp Lys Glu Arg Phe Leu Pro Asp Trp 
        835                 840                 845             


Thr Ser Thr Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln 
    850                 855                 860                 


Glu Leu Gln Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser 
865                 870                 875                 880 


Leu Asn Leu Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr 
                885                 890                 895     


Asp Ile Lys Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser 
            900                 905                 910         


Val Gln Asp Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val 
        915                 920                 925             


Cys Ser Leu Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe 
    930                 935                 940                 


Asn Asp Lys Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe 
945                 950                 955                 960 


Ser Asn Ala Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser 
                965                 970                 975     


Asn Glu Glu Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val 
            980                 985                 990         


Asn Arg Asn Ile Val His Ser Lys  Leu Phe Ala Ala Asp  His Ile Leu 
        995                 1000                 1005             


Arg Asp  Ile Val Glu Pro Val  Ser Lys Asp Asn Ile  Glu Glu Phe 
    1010                 1015                 1020             


Tyr Asp  Gln Lys Ala Glu Ile  Val Tyr Cys Lys Ile  Lys Gly Lys 
    1025                 1030                 1035             


Asp Ile  Thr Ala Glu Glu Gln  Lys Ala Val Leu Lys  Tyr Gln Lys 
    1040                 1045                 1050             


Leu Lys  Asn Arg Val Glu Leu  Arg Asp Ile Val Glu  Tyr Gly Glu 
    1055                 1060                 1065             


Ile Ile  Asn Glu Leu Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met 
    1070                 1075                 1080             


Arg Glu  Arg Asp Leu Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn 
    1085                 1090                 1095             


Cys Leu  Arg Asn Asn Ser Glu  Lys Lys Glu Ala Tyr  Gln Lys Ile 
    1100                 1105                 1110             


Glu Val  Asn Gly Asp Ser Ile  Lys Asp Ala Ile Leu  Tyr Gln Ile 
    1115                 1120                 1125             


Ile Gly  Met Tyr Val Asn Gly  Val Ala Val Tyr Ala  Pro Asp Glu 
    1130                 1135                 1140             


Lys Gly  Asp Ile Leu Lys Glu  Gln Cys Thr Lys Gly  Gly Ala Gly 
    1145                 1150                 1155             


Gly Lys  Ile Ser Ala Phe Asn  Arg Tyr Ser Glu Tyr  Leu Gly Leu 
    1160                 1165                 1170             


Asp Lys  Leu Thr Leu Tyr Asn  Ala Gly Leu Glu Ile  Phe Glu Val 
    1175                 1180                 1185             


Val Ala  Glu His Asp Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp 
    1190                 1195                 1200             


His Phe  Lys Tyr Tyr Leu Gly  Asp Tyr Arg Ser Met  Leu Ser Ile 
    1205                 1210                 1215             


Tyr Ser  Glu Val Phe Asp Arg  Phe Phe Thr Tyr Asp  Ile Lys Tyr 
    1220                 1225                 1230             


Gln Lys  Asn Val Leu Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His 
    1235                 1240                 1245             


Asn Val  Ile Val Glu Pro Val  Leu Glu Ser Gly Phe  Lys Thr Ile 
    1250                 1255                 1260             


Gly Lys  Gln Thr Thr Ser Gly  Ala Lys Leu Ser Ile  Arg Ser Ile 
    1265                 1270                 1275             


Lys Ser  Asp Thr Phe Gln Tyr  Lys Val Lys Gly Gly  Ser Leu Ile 
    1280                 1285                 1290             


Thr Asp  Ala Lys Asp Glu Arg  Tyr Leu Lys Thr Ile  Arg Lys Ile 
    1295                 1300                 1305             


Leu Tyr  Tyr Val Glu Asn Glu  Glu Asp Asn Leu Lys  Lys Ser Val 
    1310                 1315                 1320             


Val Val  Thr Asn Ala Asp Lys  Tyr Glu Lys Asn Lys  Glu Ser Asp 
    1325                 1330                 1335             


Asp Gln  Asn Lys Gln Lys Glu  Lys Lys Asn Lys Asp  Asn Lys Gly 
    1340                 1345                 1350             


Lys Lys  Asn Glu Glu Thr Lys  Ser Asp Ala Gly Lys  Asn Asn Asn 
    1355                 1360                 1365             


Glu Arg  Leu Ser Tyr Asn Pro  Phe Ala Asn Leu Asn  Phe Lys Leu 
    1370                 1375                 1380             


Pro Asn  
    1385 


<210>  1185
<211>  1385
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1185

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Pro Gly Thr Asp Thr 
            20                  25                  30          


Ile Asp Leu Asn Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Thr Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Asp Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Glu Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Gly Leu Phe Val Asn Ile 
                325                 330                 335     


Pro Asp Val Leu Met Lys Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Ile Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Ser Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg 
465                 470                 475                 480 


Asn Gly Ile Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Tyr Glu Asn 
                485                 490                 495     


Leu Gln Arg Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu 
            500                 505                 510         


Ala Arg Ala Val Cys Asp Met Ser Asn Leu Lys Asp Arg Glu Ser Asp 
        515                 520                 525             


Phe Leu Leu Trp Lys Lys Glu Asp Ile Ala Asp Lys Leu Lys Asn Lys 
    530                 535                 540                 


Asp Asp Met Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys 
545                 550                 555                 560 


Ser Ser Trp Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn 
                565                 570                 575     


Lys Tyr Asn Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile 
            580                 585                 590         


Tyr Cys Ala Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn 
        595                 600                 605             


Asn Glu Lys Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu 
    610                 615                 620                 


Thr Glu Phe Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn 
625                 630                 635                 640 


Leu Tyr Met Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Gln 
                645                 650                 655     


Leu Tyr Ser Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn 
            660                 665                 670         


Ser Val Phe Ile Arg Lys Asn Phe Pro Glu Asp Ile Thr Asn Val Leu 
        675                 680                 685             


Arg Tyr Gln Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr 
    690                 695                 700                 


Ser Ala Cys Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu 
705                 710                 715                 720 


Gln Ser Asp Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu 
                725                 730                 735     


Ser Trp Asp Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn 
            740                 745                 750         


His Phe Ser Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys 
        755                 760                 765             


Gln Ile Tyr Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys 
    770                 775                 780                 


Val Arg Ser Ser Asn Asp Ser Ile Phe Asp Lys Pro Ile Tyr His His 
785                 790                 795                 800 


Tyr Lys Val Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr 
                805                 810                 815     


Leu Lys Tyr Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys 
            820                 825                 830         


Ala Asn Glu Ile Arg Lys Ile Asp Lys Glu Arg Phe Leu Pro Asp Trp 
        835                 840                 845             


Thr Ser Thr Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln 
    850                 855                 860                 


Glu Leu Gln Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser 
865                 870                 875                 880 


Leu Asn Leu Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr 
                885                 890                 895     


Asp Ile Lys Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser 
            900                 905                 910         


Val Gln Asp Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val 
        915                 920                 925             


Cys Ser Leu Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe 
    930                 935                 940                 


Asn Asp Lys Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe 
945                 950                 955                 960 


Ser Asn Ala Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser 
                965                 970                 975     


Asn Glu Glu Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val 
            980                 985                 990         


Asn Arg Asn Ile Val His Ser Lys  Leu Phe Ala Ala Asp  His Ile Leu 
        995                 1000                 1005             


Arg Asp  Ile Val Glu Pro Val  Ser Lys Asp Asn Ile  Glu Glu Phe 
    1010                 1015                 1020             


Tyr Asp  Gln Lys Ala Glu Ile  Val Tyr Cys Lys Ile  Lys Gly Lys 
    1025                 1030                 1035             


Asp Ile  Thr Ala Glu Glu Gln  Lys Ala Val Leu Lys  Tyr Gln Lys 
    1040                 1045                 1050             


Leu Lys  Asn Arg Val Glu Leu  Arg Asp Ile Val Glu  Tyr Gly Glu 
    1055                 1060                 1065             


Ile Ile  Asn Glu Leu Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met 
    1070                 1075                 1080             


Arg Glu  Arg Asp Leu Leu Tyr  Phe Gln Leu Gly Phe  His Tyr Asn 
    1085                 1090                 1095             


Cys Leu  Arg Asn Asn Ser Glu  Lys Lys Glu Ala Tyr  Gln Lys Ile 
    1100                 1105                 1110             


Glu Val  Asn Gly Asp Ser Ile  Lys Asp Ala Ile Leu  Tyr Gln Ile 
    1115                 1120                 1125             


Ile Gly  Met Tyr Val Asn Gly  Val Ala Val Tyr Ala  Pro Asp Glu 
    1130                 1135                 1140             


Lys Gly  Asp Ile Leu Lys Glu  Gln Cys Thr Lys Gly  Gly Ala Gly 
    1145                 1150                 1155             


Gly Lys  Ile Ser Ala Phe Asn  Arg Tyr Ser Glu Tyr  Leu Gly Leu 
    1160                 1165                 1170             


Asp Lys  Leu Thr Leu Tyr Asn  Ala Gly Leu Glu Ile  Phe Glu Val 
    1175                 1180                 1185             


Val Ala  Glu His Asp Asp Ile  Ile Asn Leu Arg Asn  Gly Ile Asp 
    1190                 1195                 1200             


His Phe  Lys Tyr Tyr Leu Gly  Asp Tyr Arg Ser Met  Leu Ser Ile 
    1205                 1210                 1215             


Tyr Ser  Glu Val Phe Asp Arg  Phe Phe Thr Tyr Asp  Ile Lys Tyr 
    1220                 1225                 1230             


Gln Lys  Asn Val Leu Asn Leu  Leu Gln Asn Ile Leu  Leu Arg His 
    1235                 1240                 1245             


Asn Val  Ile Val Glu Pro Val  Leu Glu Ser Gly Phe  Lys Thr Ile 
    1250                 1255                 1260             


Gly Lys  Gln Thr Thr Ser Gly  Ala Lys Leu Ser Ile  Arg Ser Ile 
    1265                 1270                 1275             


Lys Ser  Asp Thr Phe Gln Tyr  Lys Val Lys Gly Gly  Ser Leu Ile 
    1280                 1285                 1290             


Thr Asp  Ala Lys Asp Glu Arg  Tyr Leu Lys Thr Ile  Arg Lys Ile 
    1295                 1300                 1305             


Leu Tyr  Tyr Val Glu Asn Glu  Glu Asp Asn Leu Lys  Lys Ser Val 
    1310                 1315                 1320             


Val Val  Thr Asn Ala Asp Lys  Tyr Glu Lys Asn Lys  Glu Ser Asp 
    1325                 1330                 1335             


Asp Gln  Asn Lys Gln Lys Glu  Lys Lys Asn Lys Asp  Asn Lys Gly 
    1340                 1345                 1350             


Lys Lys  Asn Glu Glu Thr Lys  Ser Asp Ala Gly Lys  Asn Asn Asn 
    1355                 1360                 1365             


Glu Arg  Leu Ser Tyr Asn Pro  Phe Ala Asn Leu Asn  Phe Lys Leu 
    1370                 1375                 1380             


Pro Asn  
    1385 


<210>  1186
<211>  1104
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1186

Met Arg Ile Val Lys Pro His Gly Thr Ser Glu Thr His Phe Asp Lys 
1               5                   10                  15      


Glu Gly Arg Ile Arg Arg Tyr Val His Ser Asp Ser Phe Pro Cys Glu 
            20                  25                  30          


Pro Leu Glu Pro Lys Glu Phe Ala Thr Arg His Pro Lys Leu Val Ile 
        35                  40                  45              


Ala Gln Trp Val Ser Cys Ile Asp Lys Val Ile Thr Arg Pro His Gly 
    50                  55                  60                  


Asp Gly Leu Pro Ser Glu Thr Gln Trp Ser Leu Arg Asn Gly Leu Gly 
65                  70                  75                  80  


Lys Ala Ala Trp Asp Leu Ile Val Glu Arg Gly Leu Leu Asp Ala Pro 
                85                  90                  95      


Glu Lys Arg Leu Lys Arg Phe Glu Arg Gln Trp Trp Ala Arg Ile His 
            100                 105                 110         


Pro Tyr Gly Asn Glu Thr Asp Ala Asn Thr Pro Arg Asn Pro Tyr Gly 
        115                 120                 125             


His Trp Tyr Arg Ser Leu Ala Gly Gly Val Asp Ile Ala Glu Phe Asp 
    130                 135                 140                 


Pro Ala Thr Val Ala Asn Met Ile Tyr Ala His Leu Tyr Glu Asn Ala 
145                 150                 155                 160 


Ser Arg Thr His Pro Glu His Gly Pro Arg Arg Ser Gly Leu Ile Pro 
                165                 170                 175     


Glu Arg Ser Glu Ser Ile Ala Lys Ser Val Pro Ala Arg Thr Ala Pro 
            180                 185                 190         


Gly Gly Gly Arg Leu Ser Pro Pro Trp Asp Ala Ser Asp Gly Ala Ile 
        195                 200                 205             


Tyr Leu Glu Ala Gly Asp Val Ala Ala Thr Met Leu Glu Arg Leu Glu 
    210                 215                 220                 


Lys His Phe Gly Glu Arg His Ala Lys Leu Arg Arg Ile Cys Ala Ala 
225                 230                 235                 240 


Thr Leu Ala Glu His Leu Thr Arg Leu Arg Arg Glu Val Leu His Ile 
                245                 250                 255     


Ser Asp Gly Asp Arg Leu Pro Glu Ser Leu Tyr Gln Leu His Glu Gln 
            260                 265                 270         


Val Arg Arg Ser Tyr Ser Asp Ile Leu Lys Gly Asp Gln Arg Tyr Leu 
        275                 280                 285             


Ser Lys Lys Leu Pro Ser Ser Gly Asp Gln Leu Val Ser Leu Val Glu 
    290                 295                 300                 


Ser Lys Arg Leu Asn Arg Glu Val Ala Ala Leu Ile Arg Leu Gly Arg 
305                 310                 315                 320 


Val Ile His Tyr Glu Ser Thr Ala Glu Asn Gly Pro Ser His Thr Ser 
                325                 330                 335     


Asn Val Leu Asp His Trp Pro Ser Gln Thr Asp Ser Ser Arg Phe Trp 
            340                 345                 350         


Leu Ser Ala Gly Gln Thr Glu Ile Lys Arg Asn Glu Ala Phe Val Arg 
        355                 360                 365             


Ile Trp Arg Gly Ile Leu Ala Arg Ala Ala Arg Thr Ala Thr Asp Trp 
    370                 375                 380                 


Ala Asp Pro Glu Arg Ala Ile Pro Arg Asp Val Leu Gly Ala Lys Gln 
385                 390                 395                 400 


Leu Ser Glu Ala Val Thr Asn Ile Thr Asp Thr Ala Phe Asp Arg Lys 
                405                 410                 415     


Ala Lys Leu Leu Phe Gly Asn Arg Ser Asp Leu Leu Thr Ser Leu Pro 
            420                 425                 430         


Leu Glu Arg Lys Arg Gln Val Leu Asp Leu Ala Leu Arg Gly Leu Gly 
        435                 440                 445             


Gln Leu Arg Asn Asn Ala Phe His Phe Val Gly Leu Glu Ala Phe Leu 
    450                 455                 460                 


Ala Ser Leu Arg Gly Leu Asp Gly Ile Ala Asp Ala Asp Thr Arg Thr 
465                 470                 475                 480 


Val Leu Asp His Ile Trp Arg Asp Asp Thr Lys Asp Arg Asn Thr Arg 
                485                 490                 495     


Leu Val Gln Thr Ile Arg Ala Ser Asn Ala Pro Ala Tyr Phe Ser Arg 
            500                 505                 510         


Gln Glu Met Glu Gly Phe Val Ser Ser Ile Ala Arg Thr Pro Ala Val 
        515                 520                 525             


Phe Leu Glu Leu Pro Ala Phe Gly Arg Ile Leu Arg Arg Ala Ser Val 
    530                 535                 540                 


Ala Trp Thr Ile Asp Arg Tyr Arg Leu Thr Leu Pro Ala Pro Lys Ala 
545                 550                 555                 560 


Val Gly Glu Pro Val Ala Ala Glu Cys Gln Arg Val Cys Leu Gly Leu 
                565                 570                 575     


Ile Tyr Asp Arg Ala Phe Gly Asp Trp Leu Gln Val Leu Glu Thr Glu 
            580                 585                 590         


Arg Leu Arg Asp Cys Val Asp Arg Ala Val Thr Arg Ala Ser Val Glu 
        595                 600                 605             


Ala Arg Arg Val Thr Arg Asp Asp Thr Val Asn Ala Arg Thr Ile Gly 
    610                 615                 620                 


Lys Phe Lys Ile Thr Gln Gly Asp Thr Leu Glu Ser Phe Phe Ser Arg 
625                 630                 635                 640 


Leu Thr Ala Ala Val Thr Arg Glu Leu Arg Gln Thr Asp Ala Arg Lys 
                645                 650                 655     


Gln Thr Lys Arg Ala Ala Ser Lys His Leu Asp Asp Leu Arg Cys Asp 
            660                 665                 670         


Val Val Ala Gln Leu Phe Glu Ile Tyr Leu Lys Glu Ala Asp Leu Gly 
        675                 680                 685             


Trp Leu Leu Ser Gly Phe Gln Thr Arg Lys Pro Thr Gly Ala Ser Lys 
    690                 695                 700                 


Thr Asp Ala Ala Phe Cys Pro Pro Pro Ser Ser Ala Gln Thr Phe Gln 
705                 710                 715                 720 


Ala Trp Glu Pro Ile Leu Tyr Phe Ile Leu His Leu Val Pro Val Asp 
                725                 730                 735     


Thr Thr Thr Arg Leu Ala His Gln Val Gly Arg Phe Arg Asp Gly Gly 
            740                 745                 750         


Gln Ile Asp Thr Gly Leu Ile Glu Gly Leu Gln Arg Thr Leu Asp Leu 
        755                 760                 765             


Tyr Arg Val Met His Asp Ala Lys Phe Ala Gly Ala Ala Ser Gly Leu 
    770                 775                 780                 


Arg Pro Asp Glu Met Arg Ser Ile Leu Leu Lys Thr Gly Leu Tyr Ser 
785                 790                 795                 800 


Gly Ala Thr Glu Gly Thr Glu Leu Ala Phe Glu Thr Arg Gly Leu Arg 
                805                 810                 815     


Glu Phe Phe Arg Phe Gly Asp His His Leu Phe Thr Thr Asp Phe Ala 
            820                 825                 830         


Gln Asn Pro Val Thr Arg Asp Gln Phe His Glu Ile Lys Ser Leu Arg 
        835                 840                 845             


Ala Asp Leu Ala Leu Ala Gln Asp Arg Arg Ser Ala Leu His Ala Glu 
    850                 855                 860                 


Trp Val Ser Asn Gly Lys Ala Leu Ser Gly Ala Lys His Asp Glu Tyr 
865                 870                 875                 880 


Arg Ala Leu Leu Asn Arg Ile Glu Arg Gly Arg His Leu Ser Asp His 
                885                 890                 895     


Ala Glu Leu Arg Asp His Leu Arg Leu His Gly Ile Leu Ile Asp Val 
            900                 905                 910         


Leu Ala Arg Leu Leu Asp Phe Ala Gly Gln Trp Glu Arg Asp Leu Tyr 
        915                 920                 925             


Phe Thr Thr Leu Ala Leu Ile His Leu Ala Gly Thr Thr Pro Gln Asp 
    930                 935                 940                 


Ala Phe Asp Asp Arg Arg Gly Trp His Ala Val Arg Thr Gly Gln Ile 
945                 950                 955                 960 


Leu Ala Ala Leu Arg Ser Thr Arg Asp Thr Pro Glu Met Gln Asp Ile 
                965                 970                 975     


Leu Ala Lys Leu Ala Met Val Phe Asn Ile Asp Met Pro Gly Val Arg 
            980                 985                 990         


Gly Ala Asn Val Arg Thr Arg Asn  Asp Leu Ala His Phe  Asn Cys Leu 
        995                 1000                 1005             


His Thr  Pro Ala Ala Ser Ile  Asp Leu Thr Ala Leu  Ile Asn Arg 
    1010                 1015                 1020             


Thr Arg  Ala Leu Met His Tyr  Asp Arg Lys Gln Glu  Asn Ala Val 
    1025                 1030                 1035             


Ser Lys  Ser Val Ile Glu Leu  Leu Asp Arg His Lys  Leu Val Leu 
    1040                 1045                 1050             


Ser Trp  Thr Phe Ser Gly Gly  Gln Leu Gly Lys Ser  Thr Val Arg 
    1055                 1060                 1065             


Pro Lys  Val Ile Arg His Leu  Glu Gln Pro Glu Val  Lys Glu Cys 
    1070                 1075                 1080             


Leu Val  Ser Thr Ala Phe Ser  Ala Ala Val Gly Arg  Leu Phe Gly 
    1085                 1090                 1095             


Ala Thr  Glu Lys Asp Gly 
    1100                 


<210>  1187
<211>  1385
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1187

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Pro Gly Thr Asp Thr 
            20                  25                  30          


Ile Asp Leu Lys Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Lys Val Phe Asn Gln Ile Gln Val Gly Asn Lys Pro Lys Lys 
    50                  55                  60                  


Trp Lys Lys Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Thr Glu Tyr Val Glu Ser Ser Gln Arg Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Tyr Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Asp Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Glu Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Gly Leu Phe Val Asn Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Ile Leu Ala Asp Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Ser Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg 
465                 470                 475                 480 


Asn Gly Ile Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Tyr Glu Asn 
                485                 490                 495     


Leu Gln Arg Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu 
            500                 505                 510         


Ala Arg Ala Val Cys Asp Met Ser Asn Leu Lys Asp Arg Glu Ser Asp 
        515                 520                 525             


Phe Leu Leu Trp Lys Lys Glu Asp Ile Ala Asp Lys Leu Lys Asn Lys 
    530                 535                 540                 


Asp Asp Met Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys 
545                 550                 555                 560 


Ser Ser Trp Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn 
                565                 570                 575     


Lys Tyr Asn Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile 
            580                 585                 590         


Tyr Cys Ala Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn 
        595                 600                 605             


Asn Glu Lys Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu 
    610                 615                 620                 


Thr Glu Phe Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn 
625                 630                 635                 640 


Leu Tyr Met Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Gln 
                645                 650                 655     


Leu Tyr Ser Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn 
            660                 665                 670         


Ser Val Phe Ile Arg Lys Asn Phe Pro Glu Asp Ile Thr Asn Val Leu 
        675                 680                 685             


Arg Tyr Gln Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr 
    690                 695                 700                 


Ser Ala Cys Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu 
705                 710                 715                 720 


Gln Ser Asp Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu 
                725                 730                 735     


Ser Trp Asp Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn 
            740                 745                 750         


His Phe Ser Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys 
        755                 760                 765             


Gln Ile Tyr Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys 
    770                 775                 780                 


Val Arg Ser Ser Asn Asp Ser Ile Phe Asp Lys Pro Ile Tyr Gln His 
785                 790                 795                 800 


Tyr Lys Val Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr 
                805                 810                 815     


Leu Lys Tyr Asn Lys Asn Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys 
            820                 825                 830         


Ala Asn Glu Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp 
        835                 840                 845             


Thr Ser Thr Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln 
    850                 855                 860                 


Glu Leu Gln Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser 
865                 870                 875                 880 


Leu Asn Leu Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr 
                885                 890                 895     


Asp Ile Lys Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser 
            900                 905                 910         


Val Gln Asp Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val 
        915                 920                 925             


Cys Ser Leu Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe 
    930                 935                 940                 


Asn Asp Lys Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe 
945                 950                 955                 960 


Ser Asn Ala Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser 
                965                 970                 975     


Asn Glu Glu Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val 
            980                 985                 990         


Asn Arg Asn Ile Val His Ser Lys  Leu Phe Ala Ala Asp  His Ile Leu 
        995                 1000                 1005             


Arg Asp  Ile Val Glu Pro Val  Ser Lys Gly Asp Ile  Glu Glu Phe 
    1010                 1015                 1020             


Tyr Asp  Gln Lys Ala Glu Ile  Val Tyr Cys Lys Ile  Lys Gly Lys 
    1025                 1030                 1035             


Asp Ile  Thr Ala Glu Glu Gln  Lys Ala Val Leu Lys  Tyr Gln Lys 
    1040                 1045                 1050             


Leu Lys  Asn Arg Val Glu Leu  Arg Asp Ile Val Glu  Tyr Gly Glu 
    1055                 1060                 1065             


Ile Ile  Asn Glu Leu Leu Gly  Gln Leu Ile Asn Trp  Ser Phe Met 
    1070                 1075                 1080             


Arg Glu  Arg Asp Leu Leu Tyr  Phe Gln Ile Gly Phe  His Tyr Asn 
    1085                 1090                 1095             


Cys Leu  Arg Asn Asp Ser Lys  Lys Pro Glu Glu Tyr  Glu Lys Ile 
    1100                 1105                 1110             


Glu Ile  Asp Glu Asn Ser Ile  Lys Gly Ala Ile Leu  Tyr Gln Ile 
    1115                 1120                 1125             


Ile Gly  Met Tyr Val Asn Gly  Val Ala Val Tyr Ala  Pro Glu Lys 
    1130                 1135                 1140             


Gly Gly  Asn Lys Leu Lys Glu  Gln Cys Val Lys Gly  Gly Val Gly 
    1145                 1150                 1155             


Val Lys  Val Asp Ala Phe Lys  Arg Tyr Ser Glu His  Leu Gly Leu 
    1160                 1165                 1170             


His Lys  Glu Thr Leu Tyr Asn  Ala Gly Leu Glu Ile  Phe Glu Ile 
    1175                 1180                 1185             


Ile Glu  Glu His Glu Asp Val  Ile Asn Leu Arg Asn  Ser Ile Asp 
    1190                 1195                 1200             


His Phe  Lys Tyr Tyr Leu Gly  Lys Tyr Arg Ser Met  Leu Ser Ile 
    1205                 1210                 1215             


Tyr Ser  Glu Val Phe Asp Arg  Phe Phe Thr Tyr Asp  Met Lys Tyr 
    1220                 1225                 1230             


Gln Lys  Asn Val Leu Tyr Leu  Leu Gln Asn Ile Leu  Leu Arg His 
    1235                 1240                 1245             


Asn Val  Ile Val Glu Pro Val  Phe Glu Ser Gly Val  Lys Thr Ile 
    1250                 1255                 1260             


Gly Asp  Gln Thr Lys Pro Cys  Ala Lys Leu Ser Ile  Lys Ser Ile 
    1265                 1270                 1275             


Lys Ser  Ala Ala Phe Glu Tyr  Lys Val Lys Gly Gly  Thr Leu Val 
    1280                 1285                 1290             


Thr Asp  Ala Lys Asp Glu Arg  Tyr Leu Glu Thr Ile  Arg Lys Ile 
    1295                 1300                 1305             


Leu Tyr  Tyr Ala Asp Asp Glu  Asp Ser Asn Ala Lys  Lys Pro Ala 
    1310                 1315                 1320             


Ile Val  Thr Asn Ala Asp Lys  Tyr Glu Lys Asn Lys  Glu Ser Asp 
    1325                 1330                 1335             


Asp Gln  Asn Lys Gln Lys Glu  Lys Lys Asn Lys Asp  Asn Lys Gly 
    1340                 1345                 1350             


Lys Lys  Asn Glu Glu Thr Lys  Ser Asp Ala Gly Lys  Asn Asn Asn 
    1355                 1360                 1365             


Glu Arg  Leu Ser Tyr Asn Pro  Phe Ala Asn Leu Asn  Phe Lys Leu 
    1370                 1375                 1380             


Ser Asn  
    1385 


<210>  1188
<211>  1373
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1188

Met Ala Lys His Leu Arg Pro Ile Gly Glu Ser Tyr Thr Asp Phe Leu 
1               5                   10                  15      


Asp Glu Thr Glu Phe Val Arg Leu Gly Arg Gly Leu His Arg Gly His 
            20                  25                  30          


His Gly Val Gln Ile Pro Pro Thr Glu Leu Pro Ser Tyr Leu Ala Glu 
        35                  40                  45              


Tyr Arg Lys Ala Leu Met Arg Gln Val Val Ala Val Leu Asp Lys Val 
    50                  55                  60                  


Val Gly Lys Arg Arg Arg Leu Ser Gly Met His Pro Glu Ala Tyr Arg 
65                  70                  75                  80  


Asp Arg Val His Leu Ala Glu Ala Leu Trp Val Arg Leu Val Ala Arg 
                85                  90                  95      


Val Lys Glu Ile Gly Thr Pro Pro Asp Pro Ser Glu Leu Leu Asp Leu 
            100                 105                 110         


Arg Arg Met Trp Asn Ala Lys Ala His Pro Tyr Ala Glu Tyr Asp Val 
        115                 120                 125             


Val Pro Arg Ala Pro Leu Asn Asp Gly Asn Gly Gln Lys Ile Leu Glu 
    130                 135                 140                 


Cys Arg Glu Val Asp Asp Pro Lys Ile Glu Arg Ser Asp Phe Glu Gly 
145                 150                 155                 160 


Arg Trp His Gly Arg Phe Trp Gln Ser Glu Pro Gly Pro Val Asp Tyr 
                165                 170                 175     


Asn Ala Ile Ala Asp Arg Ile Phe Ala His Leu Phe Asp Gln Glu Ala 
            180                 185                 190         


Val Ile Gly Gly Gly Pro Arg Arg Glu Gly Asn Val Thr Val Pro Asp 
        195                 200                 205             


Glu Asp Ile Asn Gly Gln Pro Gly Pro Ala Thr Gly Lys Gly Leu Ile 
    210                 215                 220                 


Ile Ala Arg Gly Gln Ser Ile Val Lys Ser Ala Ser Asp Pro Arg Arg 
225                 230                 235                 240 


Ser Ser Lys Lys Val Gln Arg Thr Trp Asp Lys Ala Val Glu Arg Arg 
                245                 250                 255     


Tyr Phe Gly Asp Asp Gly Lys Gly Gly Ser Asp Ile Ala Lys Ala Ile 
            260                 265                 270         


Tyr Glu Glu Leu Gly Asp Pro Ala Thr Leu Ala Asp Pro Ile Tyr Ala 
        275                 280                 285             


Ser Trp Phe Gly Ser Arg Leu Tyr Asp His Phe Gly Ser Phe Lys Asn 
    290                 295                 300                 


Ser Leu Pro Leu Glu Leu Lys Asp Pro Phe Lys Glu Gln Ile Trp Ala 
305                 310                 315                 320 


Leu His Asn Ser Val Arg Gln Phe Tyr Gln Arg Met Ala Lys Ser Asp 
                325                 330                 335     


Arg Phe Arg Leu Ala Leu Gln Asn Ala Arg Ser Glu Val Pro Asp Arg 
            340                 345                 350         


Ser Glu Leu Leu Ala Leu Leu Pro Lys Asp His Asp His Leu Leu Leu 
        355                 360                 365             


Val Leu Gly Gly Lys Lys Lys Asn Ala Glu Met Ser Glu Leu Ile Arg 
    370                 375                 380                 


Leu Gly Lys Leu Phe Val His Ala Ser Asp Val Leu His Asp Phe Asp 
385                 390                 395                 400 


Ala Asn Asp Ala Ala Ala Leu Asp Ala Phe Lys Arg Arg Met Ser Phe 
                405                 410                 415     


Leu Ala Thr Ser Ile Gly Gln Ser Glu Ile Lys Gln Thr Glu Thr Phe 
            420                 425                 430         


Ala Arg Thr Trp Arg Gly Ala Val Gly Leu Thr Leu Arg Thr Val Lys 
        435                 440                 445             


Gly Leu Ala Asp Pro Arg Gly Ile Ile Gly Thr Pro Asp Asn Arg Asp 
    450                 455                 460                 


Leu Gly Thr Ala Gly Pro Met Lys Asp Ala Phe Asn Lys Phe Asp Gln 
465                 470                 475                 480 


Pro His Phe Gln Gln His Met Thr Ile Ile Phe Gly Asn Lys Glu Leu 
                485                 490                 495     


Gln Ala Glu Gly Asn Pro Thr Arg Ser Ser Val Phe Thr Ala Asn Gly 
            500                 505                 510         


Asp Lys Asp His Gln Ala Glu Leu Leu Trp Gly Phe Leu Cys Val Val 
        515                 520                 525             


Arg Ser Val Arg Asn Arg Thr Asn His Tyr Asn Val Arg Arg Ala Leu 
    530                 535                 540                 


Leu Arg Leu Leu Asp Glu Gly Ile Val Ser Pro Met Pro Ser Asp Pro 
545                 550                 555                 560 


Lys Lys Glu Arg Val Glu Asn Arg Asn Leu Cys Thr Val Ser Pro Thr 
                565                 570                 575     


Ala Leu Glu Ala Phe Arg Arg Leu Leu Asn Phe Asp Leu Ala Ile Gln 
            580                 585                 590         


Lys Glu Ala Val Arg Thr Ala Leu Glu Gln Ala Lys Ala Ser Glu Phe 
        595                 600                 605             


Val Glu Glu Gly Lys Leu Arg Gly Leu Val Ser Glu Leu Ala Gly Thr 
    610                 615                 620                 


Glu Asp Met Pro Ala Leu His Ile Pro Arg Phe Ser Ala Val Met Asp 
625                 630                 635                 640 


Lys Val Arg Arg Leu Ala Asp Asn Arg Asp Val Gly Leu Asp Pro Ile 
                645                 650                 655     


Leu Ser Thr Leu Gln Arg Ser Leu Pro Pro Thr Asp Lys Gln Ala Glu 
            660                 665                 670         


Ser Asp Ala Ala Arg Cys Arg Tyr Arg Leu Leu Leu Glu Leu Tyr Lys 
        675                 680                 685             


Ser Gly Phe Arg Ser Trp Phe Ser Gly Ile Gln Ser Asn Glu Glu Asn 
    690                 695                 700                 


Asn Arg Glu Ile Cys His Trp Ala Val Lys Gln Val Gly Arg Ala Lys 
705                 710                 715                 720 


Asp Ala Arg Lys Ser Glu Tyr Asp Lys Lys Thr Lys Arg His Tyr Arg 
                725                 730                 735     


Ser Pro Asn Ser Leu Ile Asp Asp Leu Gly Leu Asp Lys Phe Asp Asp 
            740                 745                 750         


Leu Thr Asp Leu Leu Glu Ala Leu Ala Ser Gln Ser Thr Arg Glu His 
        755                 760                 765             


Asp Gln Asn Leu Lys Tyr Val Pro Asp Ala Arg Val Gln Ser Gln Met 
    770                 775                 780                 


Ser Asn Arg Ile Glu Glu Phe Arg Gln Glu Leu Phe Ala His Ile Phe 
785                 790                 795                 800 


Thr Lys Tyr Leu Asp Thr His Asp Phe Gly Trp Ile Gly Ala Ile Glu 
                805                 810                 815     


Val Arg Arg Glu Ala Cys Asp Leu Ala Asp Val Val Ser Ala Phe Glu 
            820                 825                 830         


Val Arg Asp Gln Lys Phe Asp Ala Asp Trp His Ser Gln Phe Tyr Ala 
        835                 840                 845             


Trp Leu Tyr Met Val Pro Pro Ile Glu Ala Ser Arg Leu Arg His Gln 
    850                 855                 860                 


Met Arg Lys Ser Ala Val Met Asp Asp Lys Trp Ser Thr Thr Leu Glu 
865                 870                 875                 880 


Leu Thr Ser Gly Asp Arg Lys Thr Arg Asp Asp His Ala Gln Asp Val 
                885                 890                 895     


Leu Ala Asp Met Asp Arg Leu Phe Ser Leu Tyr Thr Lys Val Gln Ala 
            900                 905                 910         


Ala Gly Phe Asn Gly Gln Glu His Glu Ser Ala Leu Gly Ser Lys Ser 
        915                 920                 925             


Leu Phe Tyr Glu Asp Gly Asn Gln Phe Asp Glu Val Tyr Ser Pro Asp 
    930                 935                 940                 


Thr Glu Thr His Asn Lys Thr Phe Pro Gly Thr Arg Arg Gly Leu Arg 
945                 950                 955                 960 


Gln Leu Val Arg Tyr Ala His Leu Pro Ala Leu Glu Gly Val Phe Lys 
                965                 970                 975     


Lys His Arg Ile Thr Lys Ala Glu Val Glu Thr Phe Val Ala Leu Tyr 
            980                 985                 990         


Asp Glu Asn Arg Arg Asp Pro Gly  Ser Val Ala His Met  Leu Arg Arg 
        995                 1000                 1005             


Glu Lys  Leu Arg Thr Glu Ile  Leu Arg Ser Ile His  Asp Gly Pro 
    1010                 1015                 1020             


Lys Pro  Lys Asp Lys Asp Phe  Trp Pro Lys Leu Glu  Ala Lys Cys 
    1025                 1030                 1035             


Leu Glu  Tyr Arg Thr Val Ala  Thr Glu Thr Ala Ile  Tyr Asn Phe 
    1040                 1045                 1050             


Gln Ala  Asn Ala Ala Arg Leu  Asn Asp His Ala Arg  Leu His Gln 
    1055                 1060                 1065             


Ile Val  Met Arg Val Val Ala  Arg Leu Thr Asp Tyr  Ala Leu Ile 
    1070                 1075                 1080             


Trp Glu  Arg Asp Arg Leu Phe  Ala Phe Val Gly Met  Leu Tyr Arg 
    1085                 1090                 1095             


Gln Thr  Gly Gly Thr Gly Ile  Asn Pro Ala Met Arg  His Ala Glu 
    1100                 1105                 1110             


Lys Thr  Asn Ala Pro Pro Arg  Ile Gly Ile Leu Val  Ser Asp Ser 
    1115                 1120                 1125             


Ala Leu  Ala Lys Lys Leu Asn  Ser Asn Ser Ala Glu  Val Phe Ile 
    1130                 1135                 1140             


Pro Tyr  Leu Asp Thr Glu Thr  Gly Phe Asp Ala Pro  Arg Phe Asp 
    1145                 1150                 1155             


Asp Leu  Cys Thr Leu Leu Ser  His Glu His Ala Lys  Glu Phe Arg 
    1160                 1165                 1170             


Phe His  Phe Leu Glu Val Gly  Glu Glu Asn Ser Lys  Asp Glu Ala 
    1175                 1180                 1185             


Arg Arg  Leu Asn Glu Glu Thr  Met Gly His Arg Lys  Arg Pro Ala 
    1190                 1195                 1200             


Phe Lys  Arg Gly Thr Arg Arg  Gln Gly Ile Arg Asn  Asp Leu Ala 
    1205                 1210                 1215             


His His  Asn Val Leu Asp Leu  Ala Gly Gly Ala Gly  Pro Asn Leu 
    1220                 1225                 1230             


Thr Tyr  Val Val Asn Ala Val  Arg Ser Leu Leu Ser  Tyr Asp Arg 
    1235                 1240                 1245             


Lys Leu  Lys Asn Ala Val Pro  Lys Ser Ile Lys Arg  Ile Leu Gly 
    1250                 1255                 1260             


Glu Glu  Gly Leu Ile Ile Glu  Trp Gln Met Asn Tyr  Asp Arg Leu 
    1265                 1270                 1275             


Lys Lys  Pro Thr Val Tyr Pro  Asn Val Glu Thr His  Leu Thr Met 
    1280                 1285                 1290             


Val Pro  Pro Arg His Met Thr  Ala Pro Val Ser Phe  Thr Leu Pro 
    1295                 1300                 1305             


Arg Ala  Ser Val Arg Leu Ala  Ser Met Val Lys Ala  Val Phe Asp 
    1310                 1315                 1320             


Phe Gly  Ser Ser Gly Tyr Gly  Glu Glu Arg Met Ile  Gly Gly Arg 
    1325                 1330                 1335             


Thr Ala  Lys Gln Ala Val Tyr  Pro Asp Asp Phe Thr  Arg Arg Phe 
    1340                 1345                 1350             


Pro Gln  Thr Pro Met Gly Leu  Lys Gln Ala Thr Arg  Leu Val Phe 
    1355                 1360                 1365             


Ala Ser  Glu Asn Ser 
    1370             


<210>  1189
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1189

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Gly Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  1190
<211>  1184
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1190

Met Arg Val Ser Lys Val Lys Val Leu Gly Asn Glu Glu Thr Lys Gly 
1               5                   10                  15      


Arg Ile Val Leu Met His Arg Ser Pro Val Lys Gly Gln Leu Ile Tyr 
            20                  25                  30          


Ser Glu Asp Ala Gly Lys Arg Asp Arg Thr Glu Asp Ile Ile Pro Glu 
        35                  40                  45              


Gln Lys Leu Glu Ser Phe His Leu Ser Ile Leu Asn Lys Thr Phe Leu 
    50                  55                  60                  


Arg Lys Glu Phe Phe Lys Lys Glu Leu Lys His Glu Ala Lys Lys Asn 
65                  70                  75                  80  


Gly Leu Lys Gly Asp Ala Glu Asp Lys Tyr Ile Ser Glu Lys Leu Lys 
                85                  90                  95      


Glu Tyr His Ser Leu Leu Gln Phe Ile Asp Asp Val Leu Ser Val Lys 
            100                 105                 110         


Tyr Asn Glu Asn Arg Lys Ala Ile Lys Phe Pro Glu Tyr Leu Thr Arg 
        115                 120                 125             


Glu Met Ile Glu Ile Phe Leu Asn His Lys Phe Arg Lys Glu Val Thr 
    130                 135                 140                 


Tyr Thr Asn Lys Asn Gly Ala Ser Val Ser Phe Leu Leu Ser Thr Leu 
145                 150                 155                 160 


Ile Leu Asn Ala Ile Glu Lys His Ser Val Ile Glu Met Gln Pro Phe 
                165                 170                 175     


Val Asp Trp Arg Asn Trp Phe Val Glu Thr Lys Ser Lys Phe Leu Lys 
            180                 185                 190         


Lys Ser Ile Ile Asn Asn Cys Ile Pro Thr Asn Gly Gly Pro Ile Ser 
        195                 200                 205             


Arg Arg Arg Glu Thr Leu Met Lys Trp Arg Asp Asp Tyr Phe Thr Asn 
    210                 215                 220                 


Ala Glu Ile Asp Leu Ala Arg Leu His Lys Lys Phe Gly Thr Asp Thr 
225                 230                 235                 240 


Leu Met Ala Ser Leu Arg Glu Val Pro Gln Thr Glu Lys Ser Gly Asn 
                245                 250                 255     


Glu Tyr His Arg Leu Leu Lys Ser Cys Leu Gln Ser His Gln Lys Lys 
            260                 265                 270         


Leu Phe Gly Lys Arg Ala Glu Gly Tyr Asp Ile Asn Arg Ala Asp Asn 
        275                 280                 285             


Gln Leu Tyr Val Tyr Asn Thr Glu Val Val Lys Tyr Met Glu His Tyr 
    290                 295                 300                 


Phe Pro Val Lys Ser Ser Lys Arg Arg Asn Ser Thr Ala Glu Ile Lys 
305                 310                 315                 320 


Tyr Tyr Leu Gln Thr Asp Thr Ile Lys Cys Cys Leu His His Gln Ile 
                325                 330                 335     


Ile Asn Ala Val Arg Gly Leu Ala Leu Arg Glu Gly Lys Phe Asn Leu 
            340                 345                 350         


His Gly Phe Asp Asp Lys Leu Ile Pro Asn Glu Arg Asn Val Ser Ser 
        355                 360                 365             


Ser Ile Leu Asn Glu Leu Lys Thr Ser Glu Gly Phe Val Leu Asn Met 
    370                 375                 380                 


Leu Gly Gly Cys Ala Phe Ala Ala Asn Cys Leu Arg Asn Ile Val Asp 
385                 390                 395                 400 


Ala Thr Gln Arg Ser Asp Leu Leu Gly Phe Arg Cys Phe Glu Val Ser 
                405                 410                 415     


Leu Lys Lys Gly Lys Ser Asn Ser Asp Leu Phe Ala Leu Phe Phe Gly 
            420                 425                 430         


Phe Gly Arg Glu Asp Met Asp Asp Asp Ser Glu Trp Glu Lys His Leu 
        435                 440                 445             


Tyr Ala Ala Arg Tyr Ser Val Ser Glu Ile Arg Asn Arg Val Ala His 
    450                 455                 460                 


Tyr His Lys Ser Ala Ile Glu Asn Ile Tyr Asn Ile Thr Asp Phe Glu 
465                 470                 475                 480 


Tyr Arg Glu Asn Ser Met Cys Ser Tyr Thr Asp Thr Lys Phe Thr Thr 
                485                 490                 495     


Ala Leu Gln Asn Glu Ile Tyr Asn Thr Pro Lys Ala Phe Ser Leu Gln 
            500                 505                 510         


Leu Met Thr Gly Lys Val Leu Glu Tyr Tyr Pro Lys Glu Lys Leu Val 
        515                 520                 525             


Ser Phe Phe Gln Lys Tyr Lys Phe Ser Leu Tyr Arg Ser Val Val Pro 
    530                 535                 540                 


Phe Ala Pro Gly Phe Lys Asn Ile Met Arg Thr Gly Val Asn Tyr Gln 
545                 550                 555                 560 


Asn Ala Thr Gln Asn Arg Leu Phe Tyr Asp Met Gly Leu Thr Ala Phe 
                565                 570                 575     


Gln Asp Lys Asp Arg Tyr Ile Asp Asp Val Glu Ala Trp Asn Ala Arg 
            580                 585                 590         


Tyr Phe Phe Met Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Arg Phe 
        595                 600                 605             


Thr Asn Asp Lys Asn Asp Leu Phe Arg Lys Thr Val Glu Gln Val Leu 
    610                 615                 620                 


Glu Val Asn Arg Ser His Met Glu Lys Val Gly Lys Asp Asp Arg Gln 
625                 630                 635                 640 


Ala Phe Gly Glu Val Arg Gln Met Arg Glu Asn Glu Thr Ala Asn Asp 
                645                 650                 655     


Tyr Met Ala Tyr Leu Gln Ser Ser Leu Arg Met Glu Lys Asn Lys Lys 
            660                 665                 670         


Glu Leu Glu Gly Asn Gly Ala Lys Arg Ile Asn Phe Glu Lys Phe Ile 
        675                 680                 685             


Leu Gln Met Phe Val Lys Gly Phe Asp Ser Phe Leu Lys Asp Gly Ala 
    690                 695                 700                 


Phe Glu Phe Val His Ser Pro Glu Asn Cys Leu Thr Gly Ser Thr Glu 
705                 710                 715                 720 


Lys Glu Arg Ala Lys Glu Arg Asn Ser Leu Cys Glu Glu Ile Gly Asn 
                725                 730                 735     


Tyr Val Arg Leu Val Ser Thr Val Ile Asp Pro Gly Lys Gly Ser His 
            740                 745                 750         


Val Ala Phe Tyr Val Phe Cys Lys Met Leu Asn Ser Val Tyr Leu Ser 
        755                 760                 765             


Asn Ile Arg Asn Glu Met Ile Lys Tyr His Lys Val Val Arg Thr Asp 
    770                 775                 780                 


Glu Leu Ala His Leu Ile Glu Ile Ile Glu Leu Cys Leu Leu Ser Ala 
785                 790                 795                 800 


Asp Ala Val Ser Gln Lys Thr Val Asn Ala Asp Lys Leu Ser His Phe 
                805                 810                 815     


Phe Ala Glu Gly Val Asn Val Asp Asp Asp Glu Asn Val Ile His Ala 
            820                 825                 830         


Ser Met Glu Thr Phe Arg Lys Tyr Gly Thr Arg Asp Leu Phe His Lys 
        835                 840                 845             


Leu Met Leu Gln Asp Asp Arg Phe Leu Val Ser Ser Asp Asp Tyr Arg 
    850                 855                 860                 


Glu Trp Glu Glu Met Lys Glu Lys Ile Glu Gly Lys Val Lys Gln Arg 
865                 870                 875                 880 


Glu Leu Leu His Ala Glu Trp Cys Glu Ala Lys Glu Lys Asp Lys Lys 
                885                 890                 895     


Ser Arg Lys Val Lys Ser Asn Ser Arg Thr Cys Phe Glu Lys Lys Phe 
            900                 905                 910         


Met Gly Ala Lys Ala Glu Glu Tyr Tyr Ser Leu Cys Asn Val Ile Asp 
        915                 920                 925             


Lys Tyr Asn Trp Leu Asp Asn Lys Leu His Leu Val His Leu Asn Lys 
    930                 935                 940                 


Leu His Asn Leu Val Ile Glu Ile Leu Gly Arg Met Val Gly Phe Thr 
945                 950                 955                 960 


Ala Leu Phe Glu Arg Asp Phe Gln Tyr Ile Cys Lys Ser Asp Ser Glu 
                965                 970                 975     


Tyr Glu Gln Leu Tyr Asn Leu Asp Phe Asn Met Gly Leu Pro Lys Phe 
            980                 985                 990         


Lys Asn Ser Ile Lys Gly Ser Gly  Lys Ala Lys Asn Ser  Thr Gln Asn 
        995                 1000                 1005             


Ile Asp  His Asn Ala Thr Gly  Ile Gly Asn Ser Ser  Asn Leu Leu 
    1010                 1015                 1020             


Lys Glu  Asn Ser Asn Gly Thr  His Tyr Cys Lys Asn  Leu Ser Gly 
    1025                 1030                 1035             


Asp Gly  Val Glu Asp Lys Leu  Lys Arg Leu Phe Leu  Tyr Asp Asp 
    1040                 1045                 1050             


Tyr Arg  Asn Val Arg Asn Phe  Val Ala His Phe Asn  Tyr Leu Thr 
    1055                 1060                 1065             


Arg Val  Glu Asp Asp Leu Gly  Gly Asn Asp Ala Val  Lys Leu Ser 
    1070                 1075                 1080             


Gly Thr  Arg Tyr Ser Leu Ile  Glu Leu Ile Asn Glu  Leu Arg Asn 
    1085                 1090                 1095             


Leu Leu  Lys Tyr Asp Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ser 
    1100                 1105                 1110             


Phe Ile  Asp Met Phe Glu Arg  His Gly Met His Val  Lys Met Lys 
    1115                 1120                 1125             


Leu Asn  His Asn His Lys Leu  Phe Val Asp Ser Ile  Ser Pro Arg 
    1130                 1135                 1140             


Lys Ile  Lys His Leu Gly Gly  Gly Tyr Lys Lys Arg  Gly Lys Asp 
    1145                 1150                 1155             


Asp Lys  Met Tyr Val Gln Thr  Thr Asn His Val Asp  Pro Leu Tyr 
    1160                 1165                 1170             


Cys Asp  Met Cys Arg Ala Leu  Leu Glu Met Lys 
    1175                 1180                 


<210>  1191
<211>  949
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1191

Met Pro His Gln Lys Lys Met Ala Glu Arg Ile Lys Phe Val Asn Tyr 
1               5                   10                  15      


Gly Tyr Tyr Leu Arg Leu Lys Lys Asn Cys Ala Asp Ser Phe Glu Tyr 
            20                  25                  30          


Tyr Trp Cys Asp Tyr Ile Lys Glu Phe Ile Glu Glu Asn Tyr Val Thr 
        35                  40                  45              


Lys Ile Lys Glu Ala Lys Gly Lys Asn Gly Arg Gln Leu Thr Glu Glu 
    50                  55                  60                  


Asn Cys Asn Ser Glu Ala Met Leu Ser Lys Cys Trp His Asp Met Ile 
65                  70                  75                  80  


Arg His Met Cys Ala Lys Tyr Met Asp Leu Gly Lys Ala Val Tyr His 
                85                  90                  95      


Phe Met Leu Pro Gly Lys Ala Glu Gly Asn Asp Leu Cys Leu Asp Arg 
            100                 105                 110         


Leu Asn Asp Ser Phe Ser Lys Gly Ile Thr Ser Phe Asp Tyr Glu Asn 
        115                 120                 125             


Ile Lys Ala Glu Glu Asn Leu Gln Lys Ala Met Phe Gly Val Leu Val 
    130                 135                 140                 


Ser Gly Thr Phe Asn Phe Ser Arg Ser Val Ala Asp Tyr Ser Gly Pro 
145                 150                 155                 160 


Ala Ala Ala Lys Leu Ala Lys Glu Leu Arg Ala Glu Gly Lys Thr Leu 
                165                 170                 175     


Asn Glu Asp Val Leu Met Val Asp Glu Ala His Leu Lys Ala Ile Leu 
            180                 185                 190         


Tyr Ser Asp Ala Lys Arg Lys Leu Leu Arg Tyr Phe Gly Gly Ser Ser 
        195                 200                 205             


Ala Cys Glu Ala Leu Gly Leu Asp Lys Asp Lys Met Val Leu Glu Phe 
    210                 215                 220                 


Arg Gln Ile Phe Arg Gly Leu Arg Asn Ser Ala Phe His Tyr Thr Asp 
225                 230                 235                 240 


Gly Lys Lys Ala Asp Ile Lys Phe Asp Val Thr Arg Gln Leu Trp Ile 
                245                 250                 255     


Gln Asp Val Gln Ala Asn Lys Gln Leu Ile Leu Asp Lys Tyr Tyr Ser 
            260                 265                 270         


Asn Asn Val Cys Arg Tyr Tyr Lys Pro Glu Met Val Lys Lys Leu Ile 
        275                 280                 285             


Gly Asn Leu Tyr His Gly Tyr Val Glu Gln Glu Ala Gln Ile Pro Ala 
    290                 295                 300                 


Phe Arg Thr Val Trp Lys Arg Lys Asp Phe Ala Lys Tyr Leu Asn Asp 
305                 310                 315                 320 


Ser Asn Phe Leu Pro Val Asn Ile Lys Asn Asp Val Lys Glu Arg Thr 
                325                 330                 335     


Val Phe Glu Gly Ala Leu Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg 
            340                 345                 350         


Lys Tyr Thr Val Gly Gln Asp Ala Pro Lys Tyr Phe Phe Glu Ala Val 
        355                 360                 365             


Arg Ala Tyr Ser Asp Glu His Ala Lys Asn Lys Gln Asp Pro Tyr Ala 
    370                 375                 380                 


Asn Gln Ala Lys Asn Phe Trp Asp Tyr Val Glu Lys Leu Gln Lys Ser 
385                 390                 395                 400 


Tyr Glu Lys Gly Thr Leu Thr Phe Gly Ala Val Cys Gln Thr Ile Met 
                405                 410                 415     


Thr Glu Phe Val Gln Gln Asn Ser Lys Ala Thr Glu Lys Glu Gly Glu 
            420                 425                 430         


Ile Tyr Gln His Phe Lys Val Leu Phe Pro Leu Cys Met Gln Arg Gly 
        435                 440                 445             


Phe Glu Lys Tyr Val Lys Glu Lys His Gly Tyr Leu Leu Lys Pro Trp 
    450                 455                 460                 


Leu Asp Thr Val Val Arg Glu Asn Val Leu Gln Asp Ala Ala Ile Thr 
465                 470                 475                 480 


Cys Phe Asp Asp Leu Met Arg Asp Ala Glu Asp Arg Glu Tyr Ser Trp 
                485                 490                 495     


Tyr Val Val Ala His Phe Ile His Pro Lys Lys Leu Asn His Phe Val 
            500                 505                 510         


Gly Ala Leu Lys Asp Tyr Leu Gln Phe Lys Gln Asp Ile Phe Arg Arg 
        515                 520                 525             


Cys Ser Phe Ala Asn Ile Tyr Ser Glu Gly Glu Leu Ser Gln Lys Lys 
    530                 535                 540                 


Ala Met Leu Ala Glu Lys Glu Ala Glu Ile Ser Glu Ile Leu Arg Val 
545                 550                 555                 560 


Met Glu Phe Val Arg Gly Ile Thr Gly Arg Val Ser Lys Thr Phe Ser 
                565                 570                 575     


Asp Tyr Tyr Glu Asn Glu Glu Val Tyr Ala Asn Tyr Leu Gly Lys Tyr 
            580                 585                 590         


Ile Asp Phe Pro Lys Thr Asp Gly Ile Ser Val Phe Glu Ser Phe Arg 
        595                 600                 605             


Asp Phe Cys Thr Asn Thr Leu Pro Asp Gly Asn Val Leu Asp Val Tyr 
    610                 615                 620                 


Met Asp Glu Lys Asn Pro Arg Leu Leu Lys Asn Val Glu Leu Ala Arg 
625                 630                 635                 640 


Met Tyr Ala Gly Gly Asp Val Ala Leu Lys Lys Arg Lys Arg Ile Thr 
                645                 650                 655     


Ala Lys Asp Leu Gln Arg Tyr Tyr Gly Asn Glu Val Ala Val Gln Lys 
            660                 665                 670         


Ile Leu Gln Lys Gly Leu Cys Ser Thr Arg Glu Glu Gln Gln Arg Val 
        675                 680                 685             


Leu Glu Gln Gln Asn Leu Arg Gly Arg Ile Thr Leu Asn Asp Val Thr 
    690                 695                 700                 


Glu Ile Gln Glu Ile Ile Ser Asp Met Leu Ser Gln Leu Val Thr Phe 
705                 710                 715                 720 


Ser Tyr Phe Arg Glu Arg Asp Gln Met Tyr Leu Leu Leu Gly Phe Tyr 
                725                 730                 735     


Tyr Met Ala Leu Gln Thr Asn Arg Gly Ser Ser Trp Gly Asn Glu Thr 
            740                 745                 750         


Ile Asp Phe Cys Ala Gly Lys Lys Ile Ser Ile Lys Gln Gly Trp Val 
        755                 760                 765             


Leu His Gln Val Arg Ser Val Phe Thr Tyr Gly Leu Lys Leu Tyr Ser 
    770                 775                 780                 


Glu Leu Asp Glu Lys Gly Val Gly Gly Gln Leu Ser Ser Lys Ile Val 
785                 790                 795                 800 


Ala Phe Glu Arg Val His Arg Thr Ser Leu Ala Cys Ala Leu Arg Leu 
                805                 810                 815     


Phe Met Asp Glu Asn Cys Ser Arg Arg Ala Val Asp Val Arg Asn Tyr 
            820                 825                 830         


Val Asp His Phe Lys Tyr Tyr Phe Lys Ala Asp Arg Ser Ile Met Glu 
        835                 840                 845             


Leu Tyr Ser Ala Tyr Tyr Asp Cys Phe Phe Asp Tyr Ser Thr Lys Met 
    850                 855                 860                 


Arg Lys Ser Val Leu Leu Asn Phe Ile Ser Ile Leu Glu Arg His Phe 
865                 870                 875                 880 


Val Val Ser Lys Leu Arg Val Asn Cys Leu Glu Glu Arg Cys Ser Val 
                885                 890                 895     


Ser Phe Ala Glu Ser Leu Lys Ser Glu Lys Phe Thr Tyr Lys Leu Glu 
            900                 905                 910         


Ala Asp Ala Asn Lys Lys Ser Lys Glu Gln Thr Val Glu Phe Pro Ala 
        915                 920                 925             


Arg Asp Lys Glu Phe Leu Glu Ser Leu Gln Ala Glu Leu Glu Tyr Lys 
    930                 935                 940                 


Glu Gly Tyr Asn Ser 
945                 


<210>  1192
<211>  1101
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1192

Met Arg Ile Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Ile Tyr Ser Glu 
            20                  25                  30          


Gln Ala Val Ser Asn Glu Thr Asn Asn Ile Leu Pro Val Lys Lys Met 
        35                  40                  45              


Asp Ser Phe Asn Leu Ser Ile Leu Asn Lys Thr Ile Ile Lys Phe Glu 
    50                  55                  60                  


Thr Val Lys Lys Gln Lys Leu Asn Leu Asp Gln Tyr Lys Ile Val Glu 
65                  70                  75                  80  


Lys Ile Phe Lys Tyr Pro Lys Gln Glu Leu Pro Lys Gln Ile Asn Ala 
                85                  90                  95      


Glu Glu Ile Leu Gln Phe Leu Asn His Lys Phe Gln Glu Pro Val Lys 
            100                 105                 110         


Tyr Trp Lys Asn Gly Lys Glu Glu Ser Phe Asn Leu Thr Leu Leu Ile 
        115                 120                 125             


Val Glu Ala Val Lys Thr Gln Glu Lys Arg Lys Leu Gln Pro Tyr Tyr 
    130                 135                 140                 


Asp Trp Lys Thr Trp Tyr Ile Gln Thr Lys Ser Asp Leu Leu Lys Lys 
145                 150                 155                 160 


Ser Ile Glu Asn Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg 
                165                 170                 175     


Lys Lys Ala Leu Leu Ala Trp Glu Thr Glu Phe Thr Thr Ser Gly Ser 
            180                 185                 190         


Ile Asp Leu Thr His Phe His Lys Val Tyr Met Thr Asp Val Leu Cys 
        195                 200                 205             


Thr Ala Leu Gln Lys Val Glu Pro Ser Ala Asp Glu Arg Gly Lys Met 
    210                 215                 220                 


Asn Ser Asn Ala Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Asn His 
225                 230                 235                 240 


Gln Pro Ala Ile Phe Gly Thr Arg Glu Ala Pro Asn Glu Val Asn Arg 
                245                 250                 255     


Ala Asp Asn Gln Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu 
            260                 265                 270         


Glu His Tyr Phe Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Ala Asp 
        275                 280                 285             


Asp Ile Ser His Tyr Leu Lys Ala Gln Thr Leu Lys Thr Thr Ile Glu 
    290                 295                 300                 


Lys Gln Leu Val Asn Ala Ile Arg Ala Asn Ile Ile Gln Gln Gly Lys 
305                 310                 315                 320 


Thr Asn His His Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile 
                325                 330                 335     


Arg Ile Lys Thr Asn Glu Ala Phe Val Leu Asn Leu Ile Gly Thr Cys 
            340                 345                 350         


Ala Phe Ala Ala Asn Asn Ile Arg Asn Met Val Asp Lys Glu Gln Ile 
        355                 360                 365             


Ser Asp Ile Leu Gly Lys Arg Glu Phe Ile Asp Ser Leu Thr Lys Ser 
    370                 375                 380                 


Arg Ile Ser Ser Gln Leu Tyr Ser Phe Phe Phe Gly Glu Asn Leu Ser 
385                 390                 395                 400 


Thr Asn Lys Ala Glu Lys Glu Thr Gln Leu Trp Gly Ile Arg Gly Ala 
                405                 410                 415     


Val Gln Gln Ile Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu 
            420                 425                 430         


Thr Thr Ile Phe Asn Ile Cys Lys Phe Glu Asn Pro Thr Asp Ala Asp 
        435                 440                 445             


Pro Lys Gln Gln Thr Asn Tyr Val Asp Ser Ile Tyr Lys Thr Leu Phe 
    450                 455                 460                 


Ile Lys Glu Leu Glu Lys Ile Pro Glu Ala Phe Ala Gln Gln Leu Lys 
465                 470                 475                 480 


Thr Gly Gly Ala Leu Ser Tyr Tyr Thr Val Glu Asn Leu Lys Thr Leu 
                485                 490                 495     


Leu Thr Thr Phe Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala 
            500                 505                 510         


Pro Gly Phe Lys Lys Val Leu Asn Gly Gly Ile Asn Tyr Gln Asn Ala 
        515                 520                 525             


Lys Gln Asp Glu Ser Phe Tyr Glu Leu Met Leu Glu Arg Tyr Leu Arg 
    530                 535                 540                 


Lys Glu Asn Phe Ala Glu Glu Ala Tyr Asn Ala Arg Tyr Phe Leu Leu 
545                 550                 555                 560 


Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Lys Phe Thr Ala Asp Arg 
                565                 570                 575     


Lys Ala Phe Ala Asp Ser Val Gly Phe Val Gln Leu Gln Asn Arg Lys 
            580                 585                 590         


Gln Ala Glu Asn Ser Lys Arg Pro Lys Ala Phe Ala Phe Glu Ala Val 
        595                 600                 605             


Arg Pro Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala Tyr Val 
    610                 615                 620                 


Gln Ser Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys Ala Thr 
625                 630                 635                 640 


Asp Glu Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val Phe Ile 
                645                 650                 655     


Lys Gly Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe Val Gln 
            660                 665                 670         


Val Pro Gln Pro Gln Leu Thr Thr Thr Asp Ser Asn Gln Gln Lys Ala 
        675                 680                 685             


Asp Lys Leu Asn Gln Leu Glu Ala Ser Ile Thr Ala Asp Cys Lys Leu 
    690                 695                 700                 


Thr Ala Gln Tyr Ala Lys Thr Asp Asp Ala Thr His Ile Ala Phe Tyr 
705                 710                 715                 720 


Val Phe Cys Lys Leu Leu Asp Ala Gly His Leu Ser Asn Leu Arg Asn 
                725                 730                 735     


Glu Leu Ile Lys Phe Arg Gly Ser Val Lys Asp Phe Asp Phe His His 
            740                 745                 750         


Leu Leu Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val Val Pro 
        755                 760                 765             


Thr Asp Tyr Arg Asp Leu Tyr Ser Ser Gly Ala Asp Cys Leu Ala Arg 
    770                 775                 780                 


Leu Arg Pro Phe Ile Glu Gln Gly Ala Asp Ile Lys Asn Trp Ser Asp 
785                 790                 795                 800 


Leu Tyr Val Gln Thr Asp Lys Gln Thr Pro Val Ile His Ala Gly Ile 
                805                 810                 815     


Glu Leu Ser Val Lys Tyr Gly Thr Thr Ala Leu Leu Glu Gln Leu Ile 
            820                 825                 830         


Thr Cys Asn Pro Lys Phe Arg Val Met Glu Asp Asn Phe Thr Lys Trp 
        835                 840                 845             


Ser Ala Gln Lys Lys Glu Ile Glu Glu Lys Val Asn Lys His Thr Asn 
    850                 855                 860                 


Leu His Gln Gln Trp Val Glu Ala Lys Glu Lys Asp Asp Arg Glu Arg 
865                 870                 875                 880 


Val Lys Ser Lys Lys Asn Phe Val Arg Glu Tyr Val Lys Lys Asn Tyr 
                885                 890                 895     


Val Asp Tyr Ile Asn Asn Cys Ile Glu Ile Asn Asn Tyr Asn Trp Leu 
            900                 905                 910         


Asp Asn Lys Leu His Phe Val His Leu Asn His Leu His His Leu Thr 
        915                 920                 925             


Ile Asp Ile Leu Gly Arg Met Ala Gly Phe Val Ala Leu Trp Glu Arg 
    930                 935                 940                 


Asp Phe Gln Tyr Ile Thr Lys Tyr Thr Ala Ala Lys Glu Gly Thr Asp 
945                 950                 955                 960 


Ala Leu Ser Phe Asp Gly Gly Leu Pro Arg Leu Lys Asp Lys Gln Glu 
                965                 970                 975     


Tyr Tyr Asn Lys Leu Phe Leu Ser Asp Lys Tyr Thr Lys Val Arg Asn 
            980                 985                 990         


His Ile Ala His Phe Asn Tyr Leu  Thr Lys Asp Ala Ala  Asp Phe Ala 
        995                 1000                 1005             


Leu Leu  Asp Leu Ile Asn Glu  Leu Arg Glu Leu Leu  His Tyr Gly 
    1010                 1015                 1020             


Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ala Phe Ile  Asp Leu Phe 
    1025                 1030                 1035             


Glu Lys  His Gly Met Ile Leu  Lys Leu Lys Leu Asn  Thr Asp His 
    1040                 1045                 1050             


Gln Leu  Val Val Glu Ser Ile  Glu Pro Lys Lys Ile  Tyr His Leu 
    1055                 1060                 1065             


Gly Ser  Thr Ala Lys Asp Lys  Pro Glu Tyr Gln Tyr  Thr Thr Asn 
    1070                 1075                 1080             


Gln Val  Met Thr Val Tyr Cys  Asn Met Cys Arg Ser  Leu Leu Glu 
    1085                 1090                 1095             


Met Lys  Lys 
    1100     


<210>  1193
<211>  1184
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1193

Met Arg Val Ser Lys Val Lys Val Leu Gly Asn Glu Glu Thr Lys Gly 
1               5                   10                  15      


Arg Ile Val Leu Met His Arg Ser Pro Val Lys Gly Gln Leu Ile Tyr 
            20                  25                  30          


Ser Glu Asp Ala Gly Lys Arg Asp Arg Thr Glu Asp Ile Ile Pro Glu 
        35                  40                  45              


Gln Lys Leu Glu Ser Phe His Leu Ser Ile Leu Asn Lys Thr Phe Leu 
    50                  55                  60                  


Arg Lys Glu Phe Phe Lys Lys Glu Leu Lys His Glu Ala Lys Lys Asn 
65                  70                  75                  80  


Gly Leu Lys Gly Asp Ala Glu Asp Lys Tyr Ile Ser Glu Lys Leu Lys 
                85                  90                  95      


Glu Tyr His Ser Leu Leu Gln Phe Ile Asp Asp Val Leu Ser Val Lys 
            100                 105                 110         


Tyr Asn Glu Asn Arg Lys Ala Ile Lys Phe Pro Glu Tyr Leu Thr Arg 
        115                 120                 125             


Glu Met Ile Glu Ile Phe Leu Asn His Lys Phe Arg Lys Glu Val Thr 
    130                 135                 140                 


Tyr Thr Asn Lys Asn Gly Ala Ser Val Ser Phe Leu Leu Ser Thr Leu 
145                 150                 155                 160 


Ile Leu Asn Ala Ile Glu Lys His Ser Val Ile Glu Met Gln Pro Phe 
                165                 170                 175     


Val Asp Trp Arg Asn Trp Phe Val Glu Thr Lys Ser Lys Phe Leu Lys 
            180                 185                 190         


Lys Ser Ile Ile Asn Asn Cys Ile Pro Thr Asn Gly Gly Pro Ile Ser 
        195                 200                 205             


Arg Arg Arg Glu Thr Leu Met Lys Trp Arg Asp Asp Tyr Phe Thr Asn 
    210                 215                 220                 


Ala Glu Ile Asp Leu Ala Arg Leu His Lys Lys Phe Gly Thr Asp Thr 
225                 230                 235                 240 


Leu Met Ala Ser Leu Arg Glu Val Pro Gln Thr Glu Lys Ser Gly Asn 
                245                 250                 255     


Glu Tyr His Arg Leu Leu Lys Ser Cys Leu Gln Ser His Gln Lys Lys 
            260                 265                 270         


Leu Phe Gly Lys Arg Ala Glu Gly Tyr Asp Ile Asn Arg Ala Asp Asn 
        275                 280                 285             


Gln Leu Tyr Val Tyr Asn Thr Glu Val Val Lys Tyr Met Glu His Tyr 
    290                 295                 300                 


Phe Pro Val Lys Ser Ser Lys Arg Arg Asn Ser Thr Ala Glu Ile Lys 
305                 310                 315                 320 


Tyr Tyr Leu Gln Thr Asp Thr Ile Lys Cys Cys Leu His His Gln Ile 
                325                 330                 335     


Ile Asn Ala Val Arg Gly Leu Ala Leu Arg Glu Gly Lys Phe Asn Leu 
            340                 345                 350         


His Gly Phe Asp Asp Lys Leu Ile Pro Asn Glu Arg Asn Val Ser Ser 
        355                 360                 365             


Ser Ile Leu Asn Glu Leu Lys Thr Ser Glu Gly Phe Val Leu Asn Met 
    370                 375                 380                 


Leu Gly Gly Cys Ala Phe Ala Ala Asn Cys Leu Arg Asn Ile Val Asp 
385                 390                 395                 400 


Ala Thr Gln Arg Ser Asp Leu Leu Gly Phe Arg Cys Phe Glu Val Ser 
                405                 410                 415     


Leu Lys Lys Gly Lys Ser Asn Ser Asp Leu Phe Ala Leu Phe Phe Gly 
            420                 425                 430         


Phe Gly Arg Glu Asp Met Asp Asp Asp Ser Glu Trp Glu Lys His Leu 
        435                 440                 445             


Tyr Ala Ala Arg Tyr Ser Val Ser Glu Ile Arg Asn Arg Val Ala His 
    450                 455                 460                 


Tyr His Lys Ser Ala Ile Glu Asn Ile Tyr Asn Ile Thr Asp Phe Glu 
465                 470                 475                 480 


Tyr Arg Glu Asn Ser Met Cys Ser Tyr Thr Asp Thr Lys Phe Thr Thr 
                485                 490                 495     


Ala Leu Gln Asn Glu Ile Tyr Asn Thr Pro Lys Ala Phe Ser Leu Gln 
            500                 505                 510         


Leu Met Thr Gly Lys Val Leu Glu Tyr Tyr Pro Lys Glu Lys Leu Val 
        515                 520                 525             


Ser Phe Phe Gln Lys Tyr Lys Phe Ser Leu Tyr Arg Ser Val Val Pro 
    530                 535                 540                 


Phe Ala Pro Gly Phe Lys Asn Ile Met Arg Thr Gly Val Asn Tyr Gln 
545                 550                 555                 560 


Asn Ala Thr Gln Asn Arg Leu Phe Tyr Asp Met Gly Leu Thr Ala Phe 
                565                 570                 575     


Gln Asp Lys Asp Arg Tyr Ile Asp Asp Val Glu Ala Trp Asn Ala Arg 
            580                 585                 590         


Tyr Phe Phe Met Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Arg Phe 
        595                 600                 605             


Thr Asn Asp Lys Asn Asp Leu Phe Arg Lys Thr Val Glu Gln Val Leu 
    610                 615                 620                 


Glu Val Asn Arg Ser His Met Glu Lys Val Gly Lys Asp Asp Arg Gln 
625                 630                 635                 640 


Ala Phe Gly Glu Val Arg Gln Met Arg Glu Asn Glu Thr Ala Asn Asp 
                645                 650                 655     


Tyr Met Ala Tyr Leu Gln Ser Ser Leu Arg Met Glu Lys Asn Lys Lys 
            660                 665                 670         


Glu Leu Glu Gly Asn Gly Ala Lys Arg Ile Asn Phe Glu Lys Phe Ile 
        675                 680                 685             


Leu Gln Met Phe Val Lys Gly Phe Asp Ser Phe Leu Lys Asp Gly Ala 
    690                 695                 700                 


Phe Glu Phe Val His Ser Pro Glu Asn Cys Leu Thr Gly Ser Thr Glu 
705                 710                 715                 720 


Lys Glu Arg Ala Lys Glu Arg Asn Ser Leu Cys Glu Glu Ile Gly Asn 
                725                 730                 735     


Tyr Val Arg Leu Val Ser Thr Val Ile Asp Pro Gly Lys Gly Ser His 
            740                 745                 750         


Val Ala Phe Tyr Val Phe Cys Lys Met Leu Asn Ser Val Tyr Leu Ser 
        755                 760                 765             


Asn Ile Arg Asn Glu Met Ile Lys Tyr His Lys Val Val Arg Thr Asp 
    770                 775                 780                 


Glu Leu Ala His Leu Ile Glu Ile Ile Glu Leu Cys Leu Leu Ser Ala 
785                 790                 795                 800 


Asp Ala Val Ser Gln Lys Thr Val Asn Ala Asp Lys Leu Ser His Phe 
                805                 810                 815     


Phe Ala Glu Gly Val Asn Val Asp Asp Asp Glu Asn Val Ile His Ala 
            820                 825                 830         


Ser Met Glu Thr Phe Arg Lys Tyr Gly Thr Arg Asp Leu Phe His Lys 
        835                 840                 845             


Leu Met Leu Gln Asp Asp Arg Phe Leu Val Ser Ser Asp Asp Tyr Arg 
    850                 855                 860                 


Glu Trp Glu Glu Met Lys Glu Lys Ile Glu Gly Lys Val Lys Gln Arg 
865                 870                 875                 880 


Glu Leu Leu His Ala Glu Trp Cys Glu Ala Lys Glu Lys Asp Lys Lys 
                885                 890                 895     


Ser Arg Lys Val Lys Ser Asn Ser Arg Thr Cys Phe Glu Lys Lys Phe 
            900                 905                 910         


Met Gly Ala Lys Ala Glu Glu Tyr Tyr Ser Leu Cys Asn Val Ile Asp 
        915                 920                 925             


Lys Tyr Asn Trp Leu Asp Asn Lys Leu His Leu Val His Leu Asn Lys 
    930                 935                 940                 


Leu His Asn Leu Val Ile Glu Ile Leu Gly Arg Met Val Gly Phe Thr 
945                 950                 955                 960 


Ala Leu Phe Glu Arg Asp Phe Gln Tyr Ile Cys Lys Ser Asp Ser Glu 
                965                 970                 975     


Tyr Glu Gln Leu Tyr Asn Leu Asp Phe Asn Met Gly Leu Pro Lys Phe 
            980                 985                 990         


Lys Asn Ser Ile Lys Gly Ser Gly  Lys Ala Lys Asn Ser  Thr Gln Asn 
        995                 1000                 1005             


Ile Asp  His Asn Ala Thr Gly  Ile Gly Asn Ser Ser  Asn Leu Leu 
    1010                 1015                 1020             


Lys Glu  Asn Ser Asn Gly Thr  His Tyr Cys Lys Asn  Leu Ser Gly 
    1025                 1030                 1035             


Asp Gly  Val Glu Asp Lys Leu  Lys Arg Leu Phe Leu  Tyr Asp Asp 
    1040                 1045                 1050             


Tyr Arg  Asn Val Arg Asn Phe  Val Ala His Phe Asn  Tyr Leu Thr 
    1055                 1060                 1065             


Arg Val  Glu Asp Asp Leu Gly  Gly Asn Asp Ala Val  Lys Leu Ser 
    1070                 1075                 1080             


Gly Thr  Arg Tyr Ser Leu Ile  Glu Leu Ile Asn Glu  Leu Arg Asn 
    1085                 1090                 1095             


Leu Leu  Lys Tyr Asp Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ser 
    1100                 1105                 1110             


Phe Ile  Asp Met Phe Glu Arg  His Gly Met His Val  Lys Met Lys 
    1115                 1120                 1125             


Leu Asn  His Asn His Lys Leu  Phe Val Asp Ser Ile  Ser Pro Arg 
    1130                 1135                 1140             


Lys Ile  Lys His Leu Gly Gly  Gly Tyr Lys Lys Arg  Gly Lys Asp 
    1145                 1150                 1155             


Asp Lys  Met Tyr Val Gln Thr  Thr Asn His Val Asp  Pro Leu Tyr 
    1160                 1165                 1170             


Cys Asp  Met Cys Arg Ala Leu  Leu Glu Met Lys 
    1175                 1180                 


<210>  1194
<211>  1425
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1194

Met Lys Leu Ser Lys Val Asp Arg Ile Arg Val Ala Val Gly Lys Thr 
1               5                   10                  15      


Gly Lys Thr Glu Asn Gly Asn Ser Gln Gly Arg Gly Val Leu Tyr Arg 
            20                  25                  30          


Ser Pro Lys Gly Asn Lys Thr Val Ala Val Asp Ala Val Val Glu Glu 
        35                  40                  45              


Arg Ile Arg Asn Ala Asn Arg Leu Tyr Ser Ala Phe Phe Arg Cys Ala 
    50                  55                  60                  


Tyr Pro Glu Glu Pro Glu Arg His Phe Glu Glu Ile Ile Lys Arg Met 
65                  70                  75                  80  


Ala Thr Gly Lys Lys Ser Gly Ala Gln Ile Leu Lys Glu Tyr Ile Gly 
                85                  90                  95      


Tyr Glu Gly Gln Lys Asn Arg Lys Pro Tyr Thr Phe Tyr Val Asn Lys 
            100                 105                 110         


Cys Ala Tyr Arg Pro Ala Gly Lys Glu Leu Gly Gln Val Leu Arg Leu 
        115                 120                 125             


Phe Val Lys Glu Arg Leu Gly Gln Asn Trp Gln Asn Pro Glu Ala Ala 
    130                 135                 140                 


Glu Ala Ala Val Ala Leu Leu Thr Cys Leu Cys Glu Gly Lys Thr Asn 
145                 150                 155                 160 


Arg Tyr Thr Glu Asn Thr Ala Asp Gly Pro Val Leu Thr Glu Leu Ser 
                165                 170                 175     


Glu Gln Thr Val Thr Gln Leu Glu Gln Val Ser Arg Leu Gly Gly Ser 
            180                 185                 190         


Ile Leu Val Pro Lys Thr Glu Arg Leu Glu Thr Ile Val Thr Val Ile 
        195                 200                 205             


Leu Arg Leu Thr Ala Glu Gln Cys Asn Thr Ser Leu Tyr Val Asn Gly 
    210                 215                 220                 


Gly Thr Lys Glu Ala Gln Asp Ala Asp Leu Glu Lys Gln Ile Ala Leu 
225                 230                 235                 240 


Leu Lys Ser Leu Gln Thr Lys Pro Leu Leu Leu Lys Glu Arg Phe Asp 
                245                 250                 255     


Lys Val Thr Lys Gln Thr Ile Arg Asp Glu Gln Lys Leu Ser Glu Phe 
            260                 265                 270         


Ser Tyr Lys Asp Ala Thr Lys Glu Arg Met Glu Ala Val Val Val Arg 
        275                 280                 285             


Met Arg Lys Thr Leu Lys Lys Gly Ala Ser Arg Glu Val Ala Val Glu 
    290                 295                 300                 


Leu Leu Gln Ala Leu Ala Gln Tyr Asp Gly Lys Thr Trp Asp Gly Trp 
305                 310                 315                 320 


Leu Thr Gln Met Leu Glu Thr Glu Ala Ser Lys Lys Lys Leu Lys Asp 
                325                 330                 335     


Phe Ile Leu Ala Val Asn Lys Asp Phe His His Phe His Val Ile Lys 
            340                 345                 350         


Ser Val Lys Asn Thr Ala Val Ala Val Ser His Ser Glu Asp Asn Thr 
        355                 360                 365             


Leu Gln Leu Ser Gly Ala Lys Lys Lys Thr Lys Gly Ala Met Gln Asp 
    370                 375                 380                 


Ala Leu Phe Ala Tyr Ala Gln Ser Glu Glu Ser Ser Asp Glu Thr Leu 
385                 390                 395                 400 


His Arg Ile Lys Arg Ile Leu Phe Thr Tyr Val Leu Gly Gly Arg Gln 
                405                 410                 415     


Asp Asn Thr Leu Arg Leu Thr Glu Lys Thr His Leu Ala Lys Glu Leu 
            420                 425                 430         


Leu Trp Lys Phe Arg Gly Thr Gly Ala Gly Leu Phe Asp Ala Asp Phe 
        435                 440                 445             


Val Pro Glu Glu Glu Arg Ala Gly Glu Ser Gly Arg Lys Ala Gly Ser 
    450                 455                 460                 


Tyr Thr Asp Leu Gly Cys Leu Phe Ala Glu Asp Asp Gly Ile Arg Asn 
465                 470                 475                 480 


Gln Arg Arg Ile Ala Asp Arg Ile Asn Tyr Val Asn Tyr Gly Asn Tyr 
                485                 490                 495     


Leu Arg Met Arg Lys Ala Ala Glu Asp Glu Phe Thr Leu Phe Trp Cys 
            500                 505                 510         


Ala Tyr Ile Lys Asp Tyr Ile Glu Glu Asn Tyr Val Thr Lys Ile Arg 
        515                 520                 525             


Glu Ala Lys Arg Thr Gly Gly Lys Arg Arg Leu Lys Glu Thr Asp Cys 
    530                 535                 540                 


Glu Ala Glu Arg Met Met Glu Lys Cys Trp His Asp Ile Ile Arg Tyr 
545                 550                 555                 560 


Ile Cys Gly Lys Tyr Ile His Ile Gly Lys Ala Val Tyr His Phe Ala 
                565                 570                 575     


Ile Pro Glu Asp Leu Leu Ala Asn Pro Gly Glu Val Arg Ser Phe Gly 
            580                 585                 590         


Asp Val His Ala Lys Tyr Ala Asp Gly Ile Thr Ser Phe Asp Tyr Glu 
        595                 600                 605             


Asp Ile Lys Ala Glu Glu Asn Leu Gln Lys Ser Ile Phe Asn Val Leu 
    610                 615                 620                 


Val Ser Ala Val Ala Asn Tyr Ser Arg Ser Val Val Asp Leu Ser Ser 
625                 630                 635                 640 


Glu Arg Ala Glu Glu Leu Arg Arg Leu Pro Gly Asn Glu Arg Leu Asn 
                645                 650                 655     


Glu Asp Val Leu Met Met Lys Glu Thr His Leu Lys Glu Leu Leu Leu 
            660                 665                 670         


Pro Asp Ala Lys Lys Arg Leu Leu Arg Tyr Phe Gly Gly Tyr Ser Ala 
        675                 680                 685             


Cys Glu Gly Leu Ser Gly Val Thr Ser Glu Glu Leu Ala Trp Glu Met 
    690                 695                 700                 


Arg Thr Val Leu Ser Thr Leu Arg Asn Glu Ser Phe His Tyr Thr Phe 
705                 710                 715                 720 


Gly Lys Lys Lys Lys Leu Asp Tyr Lys Val Ala Lys Gln Leu Trp Met 
                725                 730                 735     


Gln Ala Ile Arg Ala Asn Arg Gln Leu Ile Leu Asp Lys Tyr Tyr Ser 
            740                 745                 750         


Asn Asn Thr Cys Arg Tyr Tyr Ser Pro Asn Ser Ile Lys Ala Leu Ile 
        755                 760                 765             


Glu Gln Gly Tyr Arg Ser Tyr Glu Glu Arg Glu Ala Gln Ile Pro Ala 
    770                 775                 780                 


Phe Lys Thr Val Trp Lys Lys Ala Glu Leu Ala Lys Tyr Leu Ala Asp 
785                 790                 795                 800 


Lys Lys Val Met Pro Ala Glu Ile Ser Gly Glu Glu Lys Glu Arg Val 
                805                 810                 815     


Ile Phe Gln Gly Ala Phe Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg 
            820                 825                 830         


Glu Phe Thr Val Gly Asn Thr Ala Ala Lys Tyr Phe Phe Asp Ala Val 
        835                 840                 845             


Glu Arg Tyr Cys Lys Glu Asn Glu Thr Gly Pro Tyr Lys Asn Pro Ala 
    850                 855                 860                 


Lys Ser Phe Asn Asp Tyr Val Asn Gly Ala Phe Asn Asn Lys Gly Val 
865                 870                 875                 880 


Lys Val Gln Lys Gly Leu Ser Asp Leu Tyr Arg Glu Gly Lys Ile Thr 
                885                 890                 895     


Phe Gly Val Val Cys Gln Thr Ile Met Ala Glu Tyr Thr Gln Gln Asn 
            900                 905                 910         


Glu Lys Ser Glu Gly Glu Ala Ile Tyr Gln His Phe Lys Met Leu Phe 
        915                 920                 925             


Pro Leu Cys Met Arg Lys Gly Phe Gln Lys Tyr Val Glu Glu Lys His 
    930                 935                 940                 


Lys Glu Leu Leu Gln Pro Val Ile Arg Glu Met Gly Ser Arg Glu Asp 
945                 950                 955                 960 


Phe Leu Thr Asn Ile His Ile Gly Cys Phe Asp Asp Phe Cys Arg Glu 
                965                 970                 975     


Asp Gly Met Tyr Glu Tyr Asp Trp Phe Val Val Ala His Leu Ile His 
            980                 985                 990         


Pro Lys Arg Leu Asn Glu Leu Val  Gly Asn Leu Lys Asp  Tyr Met Gln 
        995                 1000                 1005             


Phe Lys  Gln Asp Ile Leu Arg  Arg Ala Asp Tyr Val  Glu Gln Phe 
    1010                 1015                 1020             


Thr Lys  Glu Glu Leu Ala Ala  Met Lys Ala Arg Thr  Glu Glu Lys 
    1025                 1030                 1035             


Leu Gln  Lys Ile Ser Gly Ile  Leu Arg Val Ala Glu  Phe Val Arg 
    1040                 1045                 1050             


Gly Ile  Ala Gly Arg Val Ser  Asn Thr Phe Ser Asp  Tyr Tyr Glu 
    1055                 1060                 1065             


Ser Glu  Glu Ala Tyr Ala Ser  Tyr Leu Glu Gln Tyr  Ile Glu Phe 
    1070                 1075                 1080             


Pro Arg  Ile Lys Gly Ser Thr  Val Phe Glu Ser Phe  Arg Asp Phe 
    1085                 1090                 1095             


Cys Val  Asn Thr Leu Pro Gly  Gly Ala Val Met Asp  Val Tyr Met 
    1100                 1105                 1110             


Asp Glu  Lys Asn Pro Arg Ile  Leu Arg Asn Val Glu  Val Ala Arg 
    1115                 1120                 1125             


Met Tyr  Ala Gly Gly Asp Ile  Gly Leu Arg Thr Arg  Lys Lys Val 
    1130                 1135                 1140             


Thr Ala  Glu Glu Leu Lys Arg  Tyr Tyr Gln Asn Glu  Ala Glu Val 
    1145                 1150                 1155             


Ala Ala  Leu Leu Lys Ala Gly  Leu Cys Ala Thr Ala  Glu Asp Gln 
    1160                 1165                 1170             


Lys Arg  Val Lys Ala Gln Gln  Glu Leu Arg Asn Arg  Ile Thr Leu 
    1175                 1180                 1185             


Thr Asp  Val Thr Glu Ile Gln  Glu Val Ile Asn Asp  Leu Leu Ser 
    1190                 1195                 1200             


Gln Leu  Val Thr Phe Ser Tyr  Phe Arg Glu Arg Asp  Glu Met Tyr 
    1205                 1210                 1215             


Leu Leu  Leu Gly Phe Tyr Tyr  Met Ala Leu Gln Ser  Asp Gly Asp 
    1220                 1225                 1230             


Trp Gly  Glu Glu Leu Arg Val  Phe Asp Gly Lys Lys  Leu Gln Val 
    1235                 1240                 1245             


Glu Asn  Gly Phe Val Leu Tyr  Gln Leu Leu Ser Ala  Phe Thr Tyr 
    1250                 1255                 1260             


Gly Leu  Asn Met Tyr Ser Glu  Ala Ala Pro Asp Gly  Lys Gly Gly 
    1265                 1270                 1275             


Ser Gln  Ala Gly Lys Ile Gly  Glu Phe Ile Lys Ala  His Pro Asn 
    1280                 1285                 1290             


Ser Trp  Asp Arg Ala Leu Arg  Leu Phe Val Asp Asp  Gly Ala Cys 
    1295                 1300                 1305             


Glu Glu  Val Ser Arg Lys Ala  Arg Asn Tyr Val Asp  His Phe Arg 
    1310                 1315                 1320             


Tyr Tyr  Val Lys Pro Asp Arg  Ser Ile Met Asp Leu  Tyr Ala Val 
    1325                 1330                 1335             


Tyr His  Glu Tyr Phe Phe Asp  Tyr Ser Thr Lys Met  Arg Lys Ser 
    1340                 1345                 1350             


Val Leu  Gln Asn Phe Ala Ser  Ile Leu Glu Arg Tyr  Phe Val Leu 
    1355                 1360                 1365             


Thr Lys  Phe Lys Leu Gly Gly  Glu Arg Gly Ala Gln  Thr Leu Glu 
    1370                 1375                 1380             


Ala Glu  Leu Ser Gly Asp Lys  Phe Thr Tyr Lys Leu  Ser Asp Thr 
    1385                 1390                 1395             


Lys Ala  Lys Pro Val Val Leu  Pro Ala Arg Asn Lys  Glu Phe Leu 
    1400                 1405                 1410             


Glu Asn  Leu Lys Asn Glu Leu  Asn Tyr Arg Gln Glu  
    1415                 1420                 1425 


<210>  1195
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1195

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Ser Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Val Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Thr Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Lys Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Val Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Lys Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Lys Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Val Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Leu Lys Glu Leu Lys Glu Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn Tyr Arg Met Gln Gln Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Lys Lys Asp Glu Lys Phe Asn Asp Lys Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Thr Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Glu Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Lys  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  1196
<211>  1177
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1196

Met Gly Thr Gly Lys Tyr Arg Ile Thr Lys Ile Gly Arg Asn Trp Lys 
1               5                   10                  15      


Glu Asn Glu Asn Lys Asn Lys Lys Arg Ile Ile Leu Lys Arg Ile Val 
            20                  25                  30          


Ser Asp Gly Glu Val Lys Tyr Val Asn Glu Asn Asp Asn Val Asp Ile 
        35                  40                  45              


Asp Ile Thr Glu Thr Tyr Tyr Gly Ile Leu Ser Asn Asn Lys Ala Lys 
    50                  55                  60                  


Phe Leu Gly Ser Asn Glu Gln Phe Leu Phe Lys Val Asn Lys Met Asp 
65                  70                  75                  80  


Arg Asn Ile Lys Asn Asp Tyr Val Ile Ile Lys Asp Tyr Thr Glu Glu 
                85                  90                  95      


Glu Phe Glu Lys Phe Asp Lys Lys Ile Phe Phe Ser Arg Lys Ile Lys 
            100                 105                 110         


Ile Asn Asn Glu Asp Arg Glu Lys Ile Cys Arg Asn Phe Tyr Glu Asp 
        115                 120                 125             


Glu Arg Glu Ile Met Lys Lys Arg Leu Glu Glu Ala Lys Asn Phe Asn 
    130                 135                 140                 


Asn Ile Ile Phe Asn Ile Cys Asn Lys Ile Phe Lys Leu Glu Tyr Leu 
145                 150                 155                 160 


Asp Tyr Thr Asp Glu Lys Val Tyr Lys Ile Phe Gln Lys Glu Ile Lys 
                165                 170                 175     


Phe Glu Asp Ile Lys Asn Leu Lys Glu Ala Phe Lys Lys Gln Glu Asn 
            180                 185                 190         


Gly Leu Glu Thr Asp Lys Leu Leu Ala Ile Ser Phe Asn Lys Lys Arg 
        195                 200                 205             


Asn Asn Ile Leu Leu Glu Phe Ile Gln Gln Ile Val Arg Gln Lys Phe 
    210                 215                 220                 


Glu Lys Glu Lys Glu Leu Glu Asn Trp Phe Ser His Glu Gly Glu Lys 
225                 230                 235                 240 


Tyr Cys Lys Glu Ile Phe Lys Ile Tyr Ser Asn Met Ser Gln Lys Glu 
                245                 250                 255     


Lys Tyr Ser Lys Leu Leu Gly His Arg Asn Lys Asn Ile Ala Ser Ile 
            260                 265                 270         


Ser Glu Lys Lys Glu Thr Leu Gln Arg Arg Leu Lys Leu Gly Asn Tyr 
        275                 280                 285             


Ser Asp Tyr Asp Leu Arg Lys Tyr Tyr Gln Lys Asp Tyr Lys Glu Glu 
    290                 295                 300                 


Ala Ile Lys Glu Leu Lys Asp Lys Asn Lys Glu Glu Leu Glu Arg Glu 
305                 310                 315                 320 


Ile Glu Glu Leu Ile Lys Lys Asn Tyr Lys Ile Asp Lys Leu Cys Asp 
                325                 330                 335     


Glu Ile Ser Asn Leu Glu Phe Phe Phe Val Glu Ser Lys Lys Glu Asn 
            340                 345                 350         


Lys Asp Lys Met Ser Glu Ile Ile Val Lys Ile Lys Glu His Tyr Lys 
        355                 360                 365             


Lys Asn Val Asn Val Glu Glu Glu Leu Lys Asn Lys Glu Lys Tyr Ile 
    370                 375                 380                 


Leu Ser Leu Ile His Asn Tyr Val Lys Gly Arg Tyr Arg Lys Cys Leu 
385                 390                 395                 400 


Glu Leu Gln Gln Lys Glu Asn Val Asp Phe Glu Asn Leu Gly Lys Arg 
                405                 410                 415     


Ile Lys Glu Ile Phe Asp Ser Asn Glu Val Thr Lys Lys Leu Lys Lys 
            420                 425                 430         


Ser Ile Ile Asn Lys Val Asn Ser Tyr Lys Ile Phe Glu Met Lys Phe 
        435                 440                 445             


Gln Asn Pro Asn Ile Glu Ser Ser Asp Asp Leu Glu Ile Leu Lys Ala 
    450                 455                 460                 


Glu Glu Thr Phe Leu Asn Lys Leu Ser Thr Ala Val Ser Lys Val Gly 
465                 470                 475                 480 


Tyr Thr Leu Asn Ile Leu Leu Gly Val Ser Ser Glu Glu Asp Ile Leu 
                485                 490                 495     


Lys Asn Tyr Asn Met Val Gly Lys Leu Cys Asn Asn Asn Ser Thr Thr 
            500                 505                 510         


Glu Ile Tyr Lys Val Tyr Pro Glu Leu Glu Lys Asn Glu Lys Leu Leu 
        515                 520                 525             


Gln Gly Met Ile His Phe Ile Gln Gly Leu Arg Gln Gln Ser Leu His 
    530                 535                 540                 


Pro Lys Ile Ser Trp Asn Phe Glu Thr Glu Asn Leu Lys Pro Glu Lys 
545                 550                 555                 560 


Leu Glu Arg Leu Lys Glu Lys Lys Asn Ile Lys Ile Arg Asp Cys Val 
                565                 570                 575     


Val His Glu Tyr Asn Leu Asp Lys Lys Glu Lys Asn Glu Val Glu Ile 
            580                 585                 590         


Lys Glu Tyr Phe Glu Lys Ile Glu Lys Lys Leu Pro Asn Tyr Phe Ile 
        595                 600                 605             


Glu Lys Tyr Glu Ser Asn Asn Val Phe Asn Ile Tyr Arg Asp Ser Val 
    610                 615                 620                 


Asp Lys Ile Met Glu Val Val Lys Lys Phe Asn Phe Lys Glu Asp Asn 
625                 630                 635                 640 


Thr Ile Asp Tyr Leu Phe Pro Lys Phe His Lys Ile Tyr Lys Lys Met 
                645                 650                 655     


Cys Lys Leu Glu Asn Ile Thr Cys Lys Ser Glu Asn Thr Asp Asp Arg 
            660                 665                 670         


Gln Asn Gly Ala Arg Lys Tyr Leu Leu Gln Thr Ile Tyr Tyr Tyr Tyr 
        675                 680                 685             


Phe Gln Tyr Glu Ile Glu Asn Asn Arg Asn Asn Ile Phe Lys Tyr Tyr 
    690                 695                 700                 


Arg Asn Lys Ile Lys Thr Glu Lys Asn Ser Tyr Arg Asp Lys Asn Ile 
705                 710                 715                 720 


Glu Ile Leu Tyr Arg Asn Ile Gln Arg Glu Gly Met Leu Asn Asn Arg 
                725                 730                 735     


Leu Leu Gln Met Asn Asn Glu Trp Ile Glu Phe Ile Met Ile Gln Phe 
            740                 745                 750         


Ile Glu Phe Ile Ser Ile Lys Lys Leu Asn Trp Ile Leu Asp Asp Leu 
        755                 760                 765             


Ser Glu Tyr Arg Lys Lys Glu Lys Leu Asp Glu Asn Asp Lys Asn Arg 
    770                 775                 780                 


Leu Leu Lys Ile Leu Lys Gln Lys Met Asn Lys Asn Ile Thr Tyr Ser 
785                 790                 795                 800 


Asn Asp Ser Tyr Val Phe Ile Ser Leu Ala Gln Phe Leu Asp Leu Lys 
                805                 810                 815     


Glu Ile Ser Asn Leu Ile His Asp Ile Lys Lys Phe Val Gln Phe Arg 
            820                 825                 830         


Glu Lys Asn Ile Ser Lys Tyr Lys Pro Glu Lys Asn Lys Val Tyr Ile 
        835                 840                 845             


Glu Glu Leu Arg Lys Ile Ser Tyr Ile Leu Lys Val Met Leu Glu His 
    850                 855                 860                 


Lys Glu Arg Val Ile Gln Lys His Tyr Leu Glu Ser Tyr Asp Glu Asp 
865                 870                 875                 880 


Ile Ser Ile Met Tyr Gly Lys Asp Ile Glu Lys Lys Asp Ile Lys Asp 
                885                 890                 895     


Ile Glu Ile Lys Ile Lys Asn Lys Asn Gln Glu Val Ile Asn Gln Pro 
            900                 905                 910         


Leu Tyr Lys Ser Gly Asn Asp Gly Asn Ser Ser Trp Ile Val Leu Tyr 
        915                 920                 925             


Gly Ile Glu Gln Ala Lys Arg Asn Gly Thr Phe Lys Phe Phe Glu Gly 
    930                 935                 940                 


Phe Phe Asn Leu Asn Glu Asp Ile Lys Leu Cys Lys Lys Asp Ile Lys 
945                 950                 955                 960 


Lys Tyr Glu Lys Leu Tyr Asn Glu Lys Glu Glu Asn Gln Lys Lys Val 
                965                 970                 975     


Asp Glu Tyr Ile Phe Tyr Glu Arg Asn Ser Tyr Ile Glu Lys Val Asn 
            980                 985                 990         


Asn Asn Ile Asn Ile Glu Lys Thr  Asn Asn Asn Lys Gln  Leu Phe Tyr 
        995                 1000                 1005             


Tyr Tyr  Lys Asn Met Ile Tyr  Gly Asp Gly Leu Lys  Lys Gly Tyr 
    1010                 1015                 1020             


Asp Phe  Ile Asn Asp Ile Tyr  Ser His Tyr Leu Ser  Trp Ala Tyr 
    1025                 1030                 1035             


Arg Ile  Glu Arg Asp Cys Lys  Ile Tyr Lys Ile Lys  Glu Tyr Glu 
    1040                 1045                 1050             


Asn Lys  Lys Asn Phe Asn Glu  Tyr Lys Phe Lys Glu  Tyr Lys Ser 
    1055                 1060                 1065             


Ile Lys  Asn Phe Arg Asn Glu  Ile Ala His Phe Asn  Tyr Phe Gln 
    1070                 1075                 1080             


Lys Thr  Asn Lys Ser Leu Leu  Glu Leu Leu Asn Asn  Phe Tyr Asp 
    1085                 1090                 1095             


Ile Phe  Asp Tyr Asn Leu Lys  Tyr Gln Arg Asp Val  Gln Lys Val 
    1100                 1105                 1110             


Ile Asn  Asn Ile Phe Glu Lys  Tyr Gln Val Ile Arg  Glu Asp Gly 
    1115                 1120                 1125             


Gly Pro  Val Ile Phe Tyr Cys  Lys Ile Glu Lys Lys  Leu Lys Leu 
    1130                 1135                 1140             


Ser Glu  Asn Ile Ile Pro Lys  Lys His Ser Lys Tyr  Pro Glu Ile 
    1145                 1150                 1155             


Lys Leu  Ile His Glu Lys Tyr  Val Glu Phe Phe Lys  Lys Leu Phe 
    1160                 1165                 1170             


Glu Tyr  Lys Lys 
    1175         


<210>  1197
<211>  1381
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1197

Met Gly Asn Leu Phe Gly His Lys Arg Trp Tyr Glu Val Ser Asp Arg 
1               5                   10                  15      


Gly Asp Asn Lys Ile Lys Arg Lys Val Lys Val Lys Arg Asn Tyr Asp 
            20                  25                  30          


Gly Asn Lys Tyr Ile Leu Asn Ile Asn Glu Asn Asn Asn Lys Glu Lys 
        35                  40                  45              


Ile Asp Asn Asn Lys Phe Ile Arg Glu Phe Val Asn Tyr Lys Lys Asn 
    50                  55                  60                  


Asp Asn Val Leu Ile Glu Phe Lys Arg Lys Phe His Ala Gly Asn Ile 
65                  70                  75                  80  


Leu Phe Lys Leu Lys Gly Asn Lys Arg Ser Ile Glu Asp Thr Asn Gly 
                85                  90                  95      


Phe Leu Lys Thr Glu Glu Ile Ile Leu Asp Lys Glu Val Tyr Gly Gln 
            100                 105                 110         


Ser Glu Lys Leu Arg Asn Glu Lys Gly Ile Thr Lys Gln Asp Ile Leu 
        115                 120                 125             


Lys Glu Ile Ile Asp Lys Gly Ile Asp Lys Ser Asn Asp Lys Ile Leu 
    130                 135                 140                 


Val Lys Thr Lys Phe Gly Lys Glu Ile Thr Ile Asn Phe Thr Asp Glu 
145                 150                 155                 160 


Asp Lys Lys Asn Lys Asn Glu Tyr Gln Ile Thr Leu Lys Ile Ile Pro 
                165                 170                 175     


Glu Asn Glu Leu Lys Ile Lys Arg Glu Val Tyr Asp Val Phe Lys Ile 
            180                 185                 190         


Ile Asn Met Asp Leu Tyr Gln Ile Ile Lys Glu Ile Ile Glu Asn Glu 
        195                 200                 205             


Val Glu Lys Val Phe Lys Asn Arg Tyr Tyr Glu Glu Tyr Leu Lys Glu 
    210                 215                 220                 


Lys Leu Leu Glu Asp Asn Gln Ile Asn Val Ile Leu Thr Asn Phe Met 
225                 230                 235                 240 


Glu Ile Arg Glu Lys Ile Lys Ser Asn Leu Glu Ile Met Gly Phe Val 
                245                 250                 255     


Lys Phe Tyr Leu Asn Val Gly Gly Asp Lys Lys Lys Ser Glu Asn Lys 
            260                 265                 270         


Lys Met Phe Val Glu Lys Ile Leu Asn Ile Asn Val Asp Leu Thr Glu 
        275                 280                 285             


Glu Asp Ile Val Asp Phe Ile Val Lys Glu Leu Lys Phe Trp Asn Ile 
    290                 295                 300                 


Thr Lys Arg Ile Glu Lys Val Lys Glu Phe Asn Asn Lys Ser Leu Glu 
305                 310                 315                 320 


Asn Arg Arg Asn Arg Thr Tyr Ile Lys Ser Tyr Val Leu Leu Asp Lys 
                325                 330                 335     


His Glu Lys Phe Lys Arg Asp Arg Glu Asn Lys Lys Asp Ile Ile Val 
            340                 345                 350         


Lys Ser Phe Ile Lys Asp Ile Lys Asn Asn Thr Met Glu Gln Lys Ile 
        355                 360                 365             


Asn Gln Ile Leu Arg Lys Phe Lys Ile Lys Glu Leu Thr Lys Lys Leu 
    370                 375                 380                 


Glu Lys Asn Thr Glu Asn Lys Asn Phe Asp Thr Glu Ile Phe Gly Ile 
385                 390                 395                 400 


Phe Lys Lys His Tyr Lys Val Asn Phe Asp Ser Lys Lys Phe Ser Asn 
                405                 410                 415     


Lys Ser Asp Glu Glu Lys Glu Leu Tyr Lys Ile Ile Tyr Arg Tyr Leu 
            420                 425                 430         


Lys Gly Arg Ile Glu Lys Ile Leu Ile Asn Glu Gln Lys Val Arg Leu 
        435                 440                 445             


Lys Lys Met Glu Lys Ile Glu Ile Glu Lys Ile Leu Asn Glu Ser Ile 
    450                 455                 460                 


Leu Ser Glu Lys Val Leu Lys Arg Val Lys Gln Tyr Thr Leu Glu His 
465                 470                 475                 480 


Val Met Tyr Leu Gly Lys Leu Ile His Asn Asp Val Asn Met Thr Thr 
                485                 490                 495     


Val Asn Thr Asp Asp Phe Thr Lys Leu His Ala Lys Glu Glu Leu Asp 
            500                 505                 510         


Leu Glu Leu Ile Thr Phe Phe Ala Ser Thr Asn Met Glu Leu Asn Lys 
        515                 520                 525             


Ile Phe Asn Gly Lys Glu Lys Ile Thr Asp Phe Phe Gly Phe Asn Leu 
    530                 535                 540                 


Asn Gly Gln Lys Ile Thr Leu Lys Glu Lys Val Pro Asn Phe Lys Leu 
545                 550                 555                 560 


Asn Ile Leu Lys Lys Leu Asn Phe Ile Asn Asn Glu Asn Asn Ile Asp 
                565                 570                 575     


Glu Lys Leu Ser His Phe Tyr Ser Phe Gln Lys Glu Gly Tyr Leu Leu 
            580                 585                 590         


Arg Asn Arg Ile Leu His Asn Ser Tyr Gly Asn Ile Gln Glu Thr Lys 
        595                 600                 605             


Asn Leu Glu Gly Glu Tyr Glu Asn Val Glu Asn Leu Ile Lys Glu Leu 
    610                 615                 620                 


Lys Val Asn Asp Glu Glu Ile Ser Lys Ser Leu Asn Leu Asp Ile Ile 
625                 630                 635                 640 


Phe Glu Gly Lys Val Asp Ile Ile Asn Lys Ile Asn Ser Leu Glu Ile 
                645                 650                 655     


Gly Glu Tyr Lys Asp Lys Lys Tyr Leu Leu Ser Phe Ser Lys Ile Val 
            660                 665                 670         


Pro Glu Ile Met Arg Lys Phe Arg Glu Ile Asn Lys Asp Lys Ser Phe 
        675                 680                 685             


Asp Ile Glu Ser Glu Lys Ile Ile Leu Asn Ala Val Gln Tyr Val Asn 
    690                 695                 700                 


Lys Ile Leu Tyr Glu Lys Ile Thr Ser Asn Glu Glu Asn Glu Phe Ile 
705                 710                 715                 720 


Lys Thr Leu Pro Asp Lys Leu Val Lys Lys Asn Asn Asn Lys Glu Asn 
                725                 730                 735     


Lys Asn Ser Leu Ser Ile Glu Glu Tyr Tyr Lys Asn Ala Gln Ile Ser 
            740                 745                 750         


Ser Ser Lys Gly Asp Lys Lys Ala Ile Lys Lys Tyr Gln Asn Lys Val 
        755                 760                 765             


Thr Asn Ala Tyr Ile Glu Tyr Leu Glu Asn Thr Phe Ala Glu Val Ile 
    770                 775                 780                 


Asp Phe Ser Asn Phe Asn Leu Asn Phe Asp Glu Ile Lys Thr Lys Ile 
785                 790                 795                 800 


Glu Glu Arg Lys Tyr Ser Lys Ser Lys Ile Thr Val Asp Ser Ile Ser 
                805                 810                 815     


Thr Asn Ile Asn Ile Thr Asn Asp Ile Glu Tyr Ile Ile Ser Ile Phe 
            820                 825                 830         


Ala Leu Leu Asn Ser Asn Thr Tyr Ile Asn Lys Ile Arg Asn Arg Phe 
        835                 840                 845             


Phe Ala Thr Ser Val Trp Leu Glu Lys Gln Asn Ser Thr Lys Glu Tyr 
    850                 855                 860                 


Asp Tyr Lys Asn Ile Ile Ser Ile Leu Asp Glu Val Leu Leu Thr Asn 
865                 870                 875                 880 


Leu Leu Arg Glu Asn Asn Ile Thr Asp Ile Leu Asp Leu Lys Asn Ala 
                885                 890                 895     


Ile Ile Asp Ala Lys Ile Val Glu Asn Asp Glu Ala Tyr Ile Lys Asn 
            900                 905                 910         


Tyr Ile Phe Glu Ser Asn Glu Glu Lys Leu Lys Lys Arg Leu Phe Cys 
        915                 920                 925             


Glu Glu Leu Ile Asp Lys Glu Asp Ile Arg Lys Ile Phe Glu Asp Lys 
    930                 935                 940                 


Asn Phe Lys Phe Lys Asn Phe Ile Lys Lys Thr Gly Asn Glu Asn Phe 
945                 950                 955                 960 


Thr Ile Asp Phe Asp Ile Leu Phe Asn Leu Glu Cys Asn Ser Glu Leu 
                965                 970                 975     


Asn Ala Lys Lys Val Ile Gly Gln Asn Ser Gln Arg Leu Asn Leu Phe 
            980                 985                 990         


Ile Lys Asn Thr Ile Asp Glu Tyr  Lys Ser Lys Ile Lys  Thr Ser Phe 
        995                 1000                 1005             


Ser Ser  Glu Phe Leu Gly Lys  Tyr Lys Lys Glu Ile  Asp Asn Leu 
    1010                 1015                 1020             


Val Glu  Asp Thr Glu Ser Glu  Asn Lys Asn Lys Phe  Glu Lys Ile 
    1025                 1030                 1035             


Tyr Tyr  Pro Glu Glu His Lys  Asn Glu Leu Tyr Ile  Tyr Lys Lys 
    1040                 1045                 1050             


Asn Leu  Phe Leu Asn Ile Gly  Asn Pro Asn Phe Asp  Lys Ile Tyr 
    1055                 1060                 1065             


Gly Leu  Ile Ser Lys Asp Ile  Lys Asn Val Asp Thr  Lys Ile Leu 
    1070                 1075                 1080             


Phe Asp  Asp Asp Ile Arg Lys  Asn Lys Ile Ser Glu  Ile Asp Ala 
    1085                 1090                 1095             


Ile Leu  Lys Asn Leu Asn Asp  Lys Leu Asn Gly Tyr  Ser Asn Asp 
    1100                 1105                 1110             


Tyr Lys  Ala Lys Tyr Val Asn  Lys Leu Lys Glu Asn  Asp Asp Phe 
    1115                 1120                 1125             


Phe Ala  Lys Asn Ile Gln Asn  Glu Asn Tyr Ser Ser  Phe Gly Glu 
    1130                 1135                 1140             


Phe Glu  Lys Asp Tyr Asn Lys  Val Ser Glu Tyr Lys  Lys Ile Arg 
    1145                 1150                 1155             


Asp Leu  Val Glu Phe Asn Tyr  Leu Asn Lys Ile Glu  Ser Tyr Leu 
    1160                 1165                 1170             


Ile Asp  Ile Asn Trp Lys Leu  Ala Ile Gln Met Ala  Arg Phe Glu 
    1175                 1180                 1185             


Arg Asp  Met His Tyr Ile Val  Asn Gly Leu Arg Glu  Leu Gly Ile 
    1190                 1195                 1200             


Ile Lys  Leu Asn Gly Tyr Asn  Thr Gly Ile Ser Arg  Ala Tyr Pro 
    1205                 1210                 1215             


Lys Arg  Asn Gly Ser Gly Asp  Phe Tyr Thr Thr Thr  Ala Tyr Tyr 
    1220                 1225                 1230             


Lys Phe  Phe Asp Glu Glu Ser  Tyr Lys Lys Phe Glu  Lys Ile Cys 
    1235                 1240                 1245             


Tyr Lys  Phe Gly Ile Asp Leu  Ser Glu Asn Ser Glu  Ile Asn Lys 
    1250                 1255                 1260             


Pro Glu  Asn Glu Ser Ile Arg  Asn Tyr Ile Ser His  Phe Tyr Ile 
    1265                 1270                 1275             


Val Arg  Asn Pro Phe Val Asp  Tyr Ser Ile Ala Glu  Gln Ile Asp 
    1280                 1285                 1290             


Arg Val  Ser Asn Leu Leu Ser  Tyr Ser Thr Arg Tyr  Asn Asn Ser 
    1295                 1300                 1305             


Thr Tyr  Ala Ser Val Phe Glu  Val Phe Lys Lys Asp  Val Asp Leu 
    1310                 1315                 1320             


Asp Tyr  Asp Glu Leu Lys Lys  Lys Phe Lys Leu Ile  Gly Asn Asn 
    1325                 1330                 1335             


Asp Ile  Leu Glu Arg Leu Met  Lys Pro Lys Lys Val  Ser Val Leu 
    1340                 1345                 1350             


Glu Leu  Glu Ser Tyr Asn Ser  Asn Tyr Val Lys Asn  Leu Ile Ile 
    1355                 1360                 1365             


Lys Leu  Leu Thr Lys Arg Lys  Asn Thr Asn Asp Thr  Leu 
    1370                 1375                 1380     


<210>  1198
<211>  1155
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1198

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Glu Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Asn Glu Lys Asn Thr Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Arg Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Val Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Ile Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Leu Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Ile Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Asn Phe Tyr Glu Lys Asp Val Ile Ile Lys Tyr Leu Lys Asn Thr Lys 
    530                 535                 540                 


Phe Asn Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Asn Lys Ile Asp Asp Leu Arg Asn Thr Leu Lys Phe Ser Trp 
                565                 570                 575     


Lys Ile Pro Lys Asp Lys Glu Glu Lys Asp Ala Gln Ile Tyr Leu Leu 
            580                 585                 590         


Lys Asn Ile Cys Tyr Gly Glu Phe Leu Asn Lys Phe Val Lys Asn Ser 
        595                 600                 605             


Lys Asp Phe Phe Lys Ile Thr Asp Glu Val Ile Lys Ile Asn Lys Gln 
    610                 615                 620                 


Arg Asn Gln Lys Thr Gly Tyr Tyr Lys Tyr Gln Lys Phe Glu Asn Ile 
625                 630                 635                 640 


Glu Lys Thr Val Pro Val Glu Tyr Leu Ala Ile Ile Gln Ser Arg Asp 
                645                 650                 655     


Met Ile Asn Asn Gln Asp Lys Glu Glu Lys Asn Thr Tyr Ile Asp Phe 
            660                 665                 670         


Val Gln Gln Ile Phe Leu Lys Gly Phe Ile Asp Tyr Leu Asn Lys Asn 
        675                 680                 685             


Asn Leu Lys Tyr Ile Glu Asn Asn Asn Asn Asn Asn Asp Ile Phe Ser 
    690                 695                 700                 


Arg Ile Lys Ile Lys Lys Asp Ser Lys Glu Arg Tyr Asp Lys Ile Leu 
705                 710                 715                 720 


Lys Asn Tyr Glu Lys Asn Asn Arg Asn Lys Glu Ile Pro His Glu Ile 
                725                 730                 735     


Asn Glu Phe Val Arg Glu Ile Lys Leu Gly Lys Ile Leu Lys Tyr Thr 
            740                 745                 750         


Glu Ser Leu Asn Met Phe Tyr Leu Ile Leu Lys Leu Leu Asn His Lys 
        755                 760                 765             


Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu Lys Tyr Gln Ser Ala Asn 
    770                 775                 780                 


Lys Glu Glu Ala Phe Ser Asp Gln Leu Glu Leu Ile Asn Leu Leu Asn 
785                 790                 795                 800 


Leu Asp Asn Asn Arg Val Thr Glu Asp Phe Glu Leu Glu Ala Asp Glu 
                805                 810                 815     


Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn Lys Ile Lys Asp Arg Lys 
            820                 825                 830         


Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile Tyr Phe Asp Gly Glu Asn 
        835                 840                 845             


Ile Ile Lys His Arg Ala Phe Tyr Asn Ile Lys Lys Tyr Gly Met Leu 
    850                 855                 860                 


Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala Lys Tyr Lys Ile Ser Leu 
865                 870                 875                 880 


Lys Glu Leu Lys Glu Tyr Ser Asn Lys Lys Asn Glu Ile Glu Lys Asn 
                885                 890                 895     


Tyr Thr Met Gln Gln Asn Leu His Arg Lys Tyr Ala Arg Pro Lys Lys 
            900                 905                 910         


Asp Glu Lys Phe Asn Asp Glu Asp Tyr Lys Glu Tyr Glu Lys Ala Ile 
        915                 920                 925             


Gly Asn Ile Gln Lys Tyr Thr His Leu Lys Asn Lys Val Glu Phe Asn 
    930                 935                 940                 


Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu Lys Ile Leu His Arg Leu 
945                 950                 955                 960 


Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp Leu Arg Phe Arg Leu Lys 
                965                 970                 975     


Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu Glu Ile Phe Asn Phe Asp 
            980                 985                 990         


Asn Ser Lys Asn Val Lys Tyr Lys  Ser Gly Gln Ile Val  Glu Lys Tyr 
        995                 1000                 1005             


Ile Asn  Phe Tyr Lys Glu Leu  Tyr Lys Asp Asn Val  Glu Lys Arg 
    1010                 1015                 1020             


Ser Ile  Tyr Ser Asp Lys Lys  Val Lys Lys Leu Lys  Gln Glu Lys 
    1025                 1030                 1035             


Lys Asp  Leu Tyr Ile Arg Asn  Tyr Ile Ala His Phe  Asn Tyr Ile 
    1040                 1045                 1050             


Pro His  Ala Glu Ile Ser Leu  Leu Glu Val Leu Glu  Asn Leu Arg 
    1055                 1060                 1065             


Lys Leu  Leu Ser Tyr Asp Arg  Lys Leu Lys Asn Ala  Val Met Lys 
    1070                 1075                 1080             


Ser Val  Val Asn Ile Leu Lys  Glu Tyr Gly Phe Val  Ala Lys Phe 
    1085                 1090                 1095             


Lys Ile  Gly Ala Asp Lys Lys  Ile Gly Ile Gln Thr  Leu Glu Ser 
    1100                 1105                 1110             


Glu Lys  Ile Val His Leu Lys  Asn Leu Lys Lys Lys  Lys Leu Met 
    1115                 1120                 1125             


Thr Asp  Arg Asn Ser Lys Glu  Leu Cys Glu Leu Val  Lys Val Met 
    1130                 1135                 1140             


Phe Glu  Tyr Lys Met Glu Glu  Lys Lys Ser Glu Asn  
    1145                 1150                 1155 


<210>  1199
<211>  1432
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1199

Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser Val Thr 
1               5                   10                  15      


Glu Asn Lys Asn Glu Glu Gln Leu Ser Arg Gln Ser Leu Leu Tyr Tyr 
            20                  25                  30          


Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp Leu Glu 
        35                  40                  45              


Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr Asn Val 
    50                  55                  60                  


Ile Thr Pro Glu Ile Asp Leu Cys Lys Glu Glu Asn Arg Glu Trp Ile 
65                  70                  75                  80  


Val Glu Asp Leu Thr Lys Asn Phe Asn Ala Val Ile Asn Asn Ala Leu 
                85                  90                  95      


Arg Ser Ile Lys Asn Pro Lys Glu Lys Arg Glu Glu Arg Val Glu Lys 
            100                 105                 110         


Glu Val Ala Phe Ile Leu Asn Leu Asn Lys Asn Ser Ile Lys Ile Lys 
        115                 120                 125             


Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe Ser Ala 
    130                 135                 140                 


Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser Lys Glu 
145                 150                 155                 160 


Glu Ala Tyr Ile Arg Glu Met Ile Ser Asn Leu Val Leu Arg Lys Leu 
                165                 170                 175     


Lys Lys Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Cys Lys Met 
            180                 185                 190         


Gln Met Thr Glu Ile Thr Ile Ser Leu Met Ser Ala Ile Cys Leu Tyr 
        195                 200                 205             


Gly Asn Val Glu Ser Phe Asp Pro Val Ile Leu Lys Ala Phe Phe Glu 
    210                 215                 220                 


Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile Val 
225                 230                 235                 240 


Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys Asp 
                245                 250                 255     


Gly Lys His Leu Leu Ile Pro Ala Asn Ala Asp His Arg Lys Lys Lys 
            260                 265                 270         


Tyr Val Phe Glu Phe Met Arg Lys Tyr Ala Ala Ala Glu Glu Lys Glu 
        275                 280                 285             


Lys Arg Glu Ile Thr Glu His Ile Gln Asn Leu Ile Gly Leu Tyr Leu 
    290                 295                 300                 


Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asn Met 
305                 310                 315                 320 


Thr Glu Ser His Asn Cys Ile Ser Gly Glu Ile Glu Glu Ile Phe Asn 
                325                 330                 335     


Glu Ile Glu Glu Leu Glu Asn Ser Ser Lys Gln Lys Arg Glu Glu Lys 
            340                 345                 350         


Lys Lys Thr Arg Glu Glu Leu Asp Lys Ile Gln Glu Ser Arg Lys Gly 
        355                 360                 365             


Asn Lys Arg Asn Thr Asn Ser Asn Asn Gln Asn Tyr Lys Asn Asn Lys 
    370                 375                 380                 


Thr Asp Ser Asp Lys Lys Glu Asn Gln Ala Asp Ala Asn Glu Asn Lys 
385                 390                 395                 400 


Leu Lys Glu Asn Glu Leu Arg Asp Lys Arg Arg Arg Leu Ser Lys Glu 
                405                 410                 415     


Leu Glu Asn Leu Asp Ser Glu Val Arg Ile Lys Lys Glu Lys Leu Lys 
            420                 425                 430         


Asn Thr Thr Val Lys Glu Met Ala Leu Lys Tyr Arg Ala Ala Val Asn 
        435                 440                 445             


Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile Lys Glu 
    450                 455                 460                 


Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr Ile Asp 
465                 470                 475                 480 


Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp Arg Tyr 
                485                 490                 495     


Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu Trp Thr 
            500                 505                 510         


Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val Tyr His 
        515                 520                 525             


Phe Ala Ile Pro Asp Leu Ser Gly Ala Leu Glu Gly Glu Ser Val Ser 
    530                 535                 540                 


Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly Phe Asp 
545                 550                 555                 560 


Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met Glu Lys 
                565                 570                 575     


Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr Pro Glu 
            580                 585                 590         


Glu Glu Arg Glu Lys Pro Gly His Glu Asp Val Leu Leu Met Lys Thr 
        595                 600                 605             


Leu Ser Glu Ile Glu Glu Ser Gln Thr Glu Glu Glu Arg Gln Lys Lys 
    610                 615                 620                 


His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp Ala Asp 
625                 630                 635                 640 


Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg Lys Lys 
                645                 650                 655     


Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr Lys Glu 
            660                 665                 670         


Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His Tyr Thr 
        675                 680                 685             


Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Glu Leu Thr Glu Tyr 
    690                 695                 700                 


Phe Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg Glu Lys 
705                 710                 715                 720 


Tyr Tyr Thr Asn Asn Val Trp Lys Tyr Tyr Asp Ile Glu Val Ile Asn 
                725                 730                 735     


Asn Ile Met Gly Lys Ile Tyr Cys Gly Arg Lys Tyr Arg Ala Ala Gln 
            740                 745                 750         


Val Pro Ala Phe Asn Asn Ile Ile Ser Arg Pro Ala Leu Pro Gln Leu 
        755                 760                 765             


Met Asp Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met Asn Cys 
    770                 775                 780                 


Pro Asp Arg Asp Val Ile Lys Lys Tyr Trp Ser Ser Leu Phe Phe Val 
785                 790                 795                 800 


Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Glu Lys Pro 
                805                 810                 815     


Glu Asp Asn Ile Lys Glu Arg Phe Phe Arg Ala Met Glu Lys Glu Ser 
            820                 825                 830         


Gly Gln Ala Lys Asp Gly Lys Glu Gln Lys Ala Trp Glu Ser Phe Glu 
        835                 840                 845             


Asn Arg Ile Asp Gln Ile Gly Arg Glu Arg Ser Phe Gly Ala Ile Cys 
    850                 855                 860                 


Gln Gly Leu Met Val Glu Tyr Met Leu Gln Asn Arg Asp Ile Ser Met 
865                 870                 875                 880 


Val Gln Thr Glu Thr Gly Asp Gly Lys Thr Asn Lys Lys Gln Ile Tyr 
                885                 890                 895     


Lys His Tyr Arg Thr Leu Leu Tyr Ile Cys Ile Arg Ser Ala Phe Thr 
            900                 905                 910         


Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro Val Leu Thr 
        915                 920                 925             


Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Gln Thr Asp Gly Leu Lys 
    930                 935                 940                 


His Leu Ser Leu Phe Asp His Leu Lys Glu Thr Phe Asn Asp Ala Glu 
945                 950                 955                 960 


Ser Gly Ser Phe Trp Tyr Met Ala Ala His Phe Ile Asn Gln Lys Tyr 
                965                 970                 975     


Leu Asn His Leu Ile Gly Ser Ile Arg Asn Tyr Leu Gln Phe Thr Glu 
            980                 985                 990         


Asp Ile Glu Asp Arg Ala Leu Ser  Leu Gly Asp Cys Val  Asp Asn Lys 
        995                 1000                 1005             


Arg Glu  Glu Lys Asn Leu Arg  Tyr Arg Asn Thr Leu  Glu Ile Leu 
    1010                 1015                 1020             


Glu Phe  Val Ala Gln Phe Cys  Glu Arg Thr Thr Asn  Val Met Glu 
    1025                 1030                 1035             


Asp Tyr  Phe Glu Ser Asn Gln  Glu Tyr Ala Ala Tyr  Leu Ser Gly 
    1040                 1045                 1050             


Phe Val  Asp Tyr Asn Val Ser  Lys Lys Glu Thr Asp  Ile Glu Lys 
    1055                 1060                 1065             


Ala Leu  Tyr Gly Phe Cys Arg  Gln Lys Phe Lys Val  Asp Gly Lys 
    1070                 1075                 1080             


Glu Tyr  Met Ala Gly Ile Tyr  Tyr Asp Gly Glu Asn  Leu Ile Pro 
    1085                 1090                 1095             


Asn Arg  Asn Ile Ile Arg Ala  Asn Met Tyr Gly Asn  Val Ser Cys 
    1100                 1105                 1110             


Leu Lys  Pro Tyr Met Asp Arg  Ile Thr Leu Lys Glu  Ile Arg Thr 
    1115                 1120                 1125             


Met Tyr  Ala Asp Gln Asn Lys  Leu Asp Thr Val Leu  Lys Glu Gly 
    1130                 1135                 1140             


Val Cys  Arg Thr Glu Glu Glu  Gln Lys Ala Tyr Arg  Glu Tyr Gln 
    1145                 1150                 1155             


Asn Glu  Lys Asn Arg Ile Glu  Leu Phe Asp Leu Cys  Thr Tyr Thr 
    1160                 1165                 1170             


Gln Ile  Leu Asn Asp Ile Gln  Ala Lys Leu Ile Gly  Trp Ser Tyr 
    1175                 1180                 1185             


Met Arg  Glu Arg Asp Leu Met  Tyr Tyr Gln Leu Gly  Tyr Tyr Tyr 
    1190                 1195                 1200             


Thr Lys  Leu Phe Trp Thr Asp  Ser Ile Ser Glu Glu  Asp Ala Arg 
    1205                 1210                 1215             


Arg Arg  Leu Met Gly Glu Leu  Val Asn Val Glu Asp  Gly Val Ile 
    1220                 1225                 1230             


Leu Tyr  Gln Ile Leu Ala Phe  Asn Ser Tyr Asn Leu  Pro Ile Ile 
    1235                 1240                 1245             


Ala Asn  Lys Asn Asn Thr Val  Thr Phe Leu Lys Gly  Glu Gly Ser 
    1250                 1255                 1260             


Ile Gly  Gly Lys Ala Ile Thr  Ala Phe Leu Lys Asn  Tyr Glu Asn 
    1265                 1270                 1275             


Ala Glu  Arg Ile Tyr Glu Glu  Ala Leu Asp Leu Phe  Glu Asn Thr 
    1280                 1285                 1290             


Asp Glu  His Ala Ala Ile Ile  Asn Thr Arg Asn Tyr  Ile Glu His 
    1295                 1300                 1305             


Phe Lys  Tyr Phe Ile Lys Ser  Asp Arg Ser Met Met  Asp Leu Tyr 
    1310                 1315                 1320             


Ser Glu  Val Tyr Asp Arg Phe  Phe Arg His Asp His  Asn Arg Lys 
    1325                 1330                 1335             


Lys Asn  Val Pro Asp Ser Leu  Lys Asn Val Leu Ala  Asp Asn Phe 
    1340                 1345                 1350             


Met Ile  Ala Asp Ile Ser Met  Glu Leu Gly Ser Lys  Lys Val Gly 
    1355                 1360                 1365             


Glu Lys  Lys Lys Gly Phe Arg  Glu His Lys Ala Ala  Arg Ile Glu 
    1370                 1375                 1380             


Phe Thr  Asp Arg Gly Ile Arg  Ser Thr Asp Met Thr  Tyr Thr Val 
    1385                 1390                 1395             


Lys Pro  Asp Pro Lys Asp Ser  Lys Lys Asp Glu Lys  Val Leu Val 
    1400                 1405                 1410             


Pro Ala  Arg Ser Glu Val Phe  Leu Lys Gln Phe Gln  Lys Ile Leu 
    1415                 1420                 1425             


Glu Tyr  Arg Ile 
    1430         


<210>  1200
<211>  1186
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1200

Met Arg Gly Gly His Met Lys Ile Thr Lys Ile Asp Gly Ile Ser His 
1               5                   10                  15      


Tyr Lys Lys Gln Asp Lys Gly Val Leu Arg Glu Lys Ile Ser Lys Glu 
            20                  25                  30          


Asp Leu Ile Glu Lys Lys Gln Arg Asp Ile Ile Glu Arg Arg Tyr Asn 
        35                  40                  45              


Lys Gln Ile Glu Ser Lys Ile Tyr Lys Glu Phe Phe Arg Leu Lys Gly 
    50                  55                  60                  


Ser Lys Arg Ile Thr Glu Glu Lys Asp Lys Ser Ile Lys Ser Leu Tyr 
65                  70                  75                  80  


Tyr Leu Ile Lys Glu Leu Tyr Glu Gly Lys Glu Asn Asn Leu Trp Glu 
                85                  90                  95      


Leu Lys Asn Ile Asn Leu Glu Ile Leu Asp Asp Lys Glu Ser Val Ile 
            100                 105                 110         


Lys Gly Tyr Lys Phe Lys Glu Asn Val Tyr Phe Phe Lys Glu Gly Asp 
        115                 120                 125             


Lys Glu Tyr His Leu Arg Thr Leu Phe Asn Asn Leu Ile Glu Lys Ile 
    130                 135                 140                 


Gln Asn Glu Asn Arg Glu Lys Val Arg Lys Asn Lys Glu Phe Leu Asp 
145                 150                 155                 160 


Leu Lys Glu Ile Phe Lys Lys Tyr Lys Asp Arg Lys Ile Tyr Leu Leu 
                165                 170                 175     


Leu Lys Ser Ile Asn Asn Asn Lys Ile Asn Ile Glu Tyr Lys Lys Glu 
            180                 185                 190         


Asn Ala Asn Glu Glu Ile Tyr Gly Ile Asn Pro Thr Asn Asp Arg Glu 
        195                 200                 205             


Lys Ile Phe Tyr Glu Leu Leu Lys Glu Ile Ile Glu Lys Lys Gly Glu 
    210                 215                 220                 


Pro Lys Ser Ile Leu Glu Glu Lys Leu Asn Asp Phe Asp Ile Thr Asn 
225                 230                 235                 240 


Phe Leu Glu Asn Ile Glu Lys Ile Phe Asn Glu Glu Ile Glu Val Asn 
                245                 250                 255     


Ile Ile Lys Gly Lys Val Leu Asn Glu Leu Arg Glu Tyr Ile Lys Glu 
            260                 265                 270         


Lys Glu Glu Asn Asn Ser Asp Asn Lys Leu Lys Lys Ile Tyr Asn Leu 
        275                 280                 285             


Glu Leu Lys Lys Tyr Ile Glu Asn Asn Phe Ser Tyr Lys Lys Gln Lys 
    290                 295                 300                 


Ser Lys Ser Lys Asn Gly Lys Asn Asp Asp Leu Tyr Leu Asn Phe Leu 
305                 310                 315                 320 


Lys Lys Ile Met Phe Ile Lys Glu Val Asp Glu Lys Lys Lys Ile Asn 
                325                 330                 335     


Lys Glu Lys Phe Lys Asn Lys Ile Asn Ser Asn Phe Lys Asn Leu Phe 
            340                 345                 350         


Val Gln His Ile Leu Asp Tyr Gly Lys Leu Leu Tyr Tyr Lys Glu Asn 
        355                 360                 365             


Asp Lys Tyr Ile Lys Asn Thr Gly Gln Leu Glu Thr Lys Asp Leu Glu 
    370                 375                 380                 


Tyr Ile Lys Thr Lys Glu Thr Leu Ile Arg Lys Met Ala Val Leu Val 
385                 390                 395                 400 


Ser Phe Ala Thr Asn Ser Tyr Tyr Asn Leu Phe Gly Lys Ile Glu Asn 
                405                 410                 415     


Asn Ile Pro Thr Gln Gly Ile Ser Asp Asp Leu Leu Leu Gly Lys Val 
            420                 425                 430         


Glu Ser Asp Ile Tyr Ile Asn Gly Glu Arg Asn Arg Arg Tyr Val Phe 
        435                 440                 445             


Lys Glu Lys Met Leu Asn Tyr Phe Phe Lys Phe Glu Ile Phe Asn Asp 
    450                 455                 460                 


Asn Lys Met Val Asp Ile Leu Asn Ser Ile Ser Ser Ser Ile Tyr Asn 
465                 470                 475                 480 


Ile Arg Asn Gly Val Asn His Phe Asp Lys Ile Asn Leu Gly Gln Tyr 
                485                 490                 495     


Asn Asn Leu Asp Leu Ser Glu Ile Lys Lys Tyr Phe Ile Glu Lys Arg 
            500                 505                 510         


Asn Lys Ile Lys Glu Lys Val Lys Glu Lys Phe Leu Ser Asn Asn Leu 
        515                 520                 525             


Gln Tyr Tyr Tyr Ala Lys Glu Glu Ile Glu Asn Tyr Phe Lys Val Tyr 
    530                 535                 540                 


Glu Phe Glu Ile Leu Lys Glu Lys Ile Pro Phe Ser Pro Asn Phe Lys 
545                 550                 555                 560 


Arg Ile Ile Lys Lys Gly Glu Asp Leu Phe Asn Asn Lys Asn Asn Lys 
                565                 570                 575     


Lys Tyr Glu Tyr Phe Lys Asn Phe Asp Lys Asn Asn Asp Asp Glu Lys 
            580                 585                 590         


Lys Glu Phe Leu Arg Thr Arg Asn Phe Leu Leu Lys Glu Leu Tyr Tyr 
        595                 600                 605             


Asn Asn Phe Tyr Lys Glu Phe Phe Ser Glu Arg Lys Lys Tyr Glu Phe 
    610                 615                 620                 


Lys Lys Ile Ile Thr Glu Val Lys Glu Glu Lys Lys Asn Arg Gly Asn 
625                 630                 635                 640 


Thr Asn Ser Lys Lys Ser Gly Val Ser Phe Gln Ser Ile Asp Asp Tyr 
                645                 650                 655     


Asn Thr Lys Ile Ser Ile Ser Asp Tyr Ile Ala Ser Ile His Lys Lys 
            660                 665                 670         


Glu Met Glu Arg Val Glu Lys Tyr Asn Glu Glu Lys Gln Lys Asp Thr 
        675                 680                 685             


Ala Lys Tyr Ile Arg Asp Phe Val Glu Glu Ile Phe Leu Thr Gly Phe 
    690                 695                 700                 


Ile Asn Tyr Leu Glu Lys Asp Lys Arg Leu His Phe Leu Lys Glu Glu 
705                 710                 715                 720 


Phe Ser Ile Leu Tyr Asn Asn Asn Asn Asn Val Ile Asp Phe Asn Val 
                725                 730                 735     


Asn Ile Asn Glu Lys Lys Ile Lys Glu Phe Leu Lys Glu Asn Asp Ser 
            740                 745                 750         


Lys Thr Leu Asn Leu Tyr Leu Phe Phe Asn Met Ile Asp Ser Lys Arg 
        755                 760                 765             


Ile Ser Glu Phe Arg Asn Glu Leu Ile Lys Tyr Lys Gln Phe Thr Lys 
    770                 775                 780                 


Lys Arg Leu Asn Lys Glu Lys Glu Phe Leu Gly Ile Lys Ile Glu Leu 
785                 790                 795                 800 


Tyr Glu Thr Leu Ile Glu Phe Val Ile Leu Thr Arg Glu Lys Leu Tyr 
                805                 810                 815     


Thr Glu Lys Ser Glu Glu Thr Asp Ala Trp Leu Val Asp Lys Leu Tyr 
            820                 825                 830         


Ile Lys Asp Asn Asn Gly Tyr Lys Glu Tyr Glu Glu Ile Leu Asn Leu 
        835                 840                 845             


Phe Val Asp Glu Lys Ile Leu Ser Leu Lys Glu Ala Pro Tyr Tyr Ala 
    850                 855                 860                 


Thr Asp Asn Lys Thr Pro Ile Ile Leu Ser Asn Phe Glu Lys Thr Arg 
865                 870                 875                 880 


Lys Tyr Gly Thr Gln Ser Leu Leu Ser Glu Ile Gln Ser Lys Tyr Lys 
                885                 890                 895     


Tyr Ser Lys Val Glu Lys Glu Asn Ile Glu Asp His Asn Lys Lys Glu 
            900                 905                 910         


Glu Ile Glu Lys Lys Glu Lys Ser Asn Ile Glu Glu Leu Tyr Asp Leu 
        915                 920                 925             


Lys Ala Glu Leu His Lys Lys Trp Glu Lys Asn Lys Ile Thr Glu Asn 
    930                 935                 940                 


Glu Thr Lys Glu Tyr Ile Asn Ile Ile Lys Lys Ile Arg Lys Tyr Ser 
945                 950                 955                 960 


Tyr Leu Lys Asn Lys Glu Glu Leu Gln Asn Val Tyr Leu Leu His Glu 
                965                 970                 975     


Ile Leu Ser Asp Leu Leu Ala Arg Asn Val Ala Phe Phe Asn Lys Trp 
            980                 985                 990         


Glu Arg Asp Phe Lys Phe Ile Val  Ile Ala Ile Lys Gln  Phe Leu Arg 
        995                 1000                 1005             


Glu Asn  Asp Lys Gln Lys Val  Asp Glu Phe Leu Asn  Pro His Lys 
    1010                 1015                 1020             


Leu Asp  Gly Ser Arg Asp Asn  Phe Ser Val Thr Asn  Tyr Arg Ser 
    1025                 1030                 1035             


Lys Met  Lys Ser Val Ile Asp  Asn Ile His Glu Asn  Phe Met Ser 
    1040                 1045                 1050             


Leu Leu  Phe Leu Asn Asn Asn  Leu Ala Thr Gly Gly  Ile Gln Val 
    1055                 1060                 1065             


Gly Arg  Asn Asn Asn Phe Thr  Trp Gly His Leu Arg  Asn Tyr Ile 
    1070                 1075                 1080             


Ala His  Phe Glu Tyr Leu His  Lys Glu Lys Glu Thr  Met Ser Phe 
    1085                 1090                 1095             


Ile Asn  Gln Ala Asn Leu Leu  Ile Lys Leu Phe Ser  Tyr Asp Lys 
    1100                 1105                 1110             


Lys Val  Gln Asn His Ile Ile  Lys Ser Met Lys Thr  Leu Leu Glu 
    1115                 1120                 1125             


Lys Tyr  Asn Ile Glu Ile Gly  Phe Glu Val Ser Asn  Asp Asn Glu 
    1130                 1135                 1140             


Glu Ile  Phe Glu Tyr Lys Ile  Lys Tyr Ile Asn Ser  Lys Lys Gly 
    1145                 1150                 1155             


Lys Ile  Leu Gly Lys Asn Asn  Lys Phe Glu Ile Leu  Glu Asp Glu 
    1160                 1165                 1170             


Phe Leu  Glu Asn Val Lys Thr  Leu Leu Glu Tyr Ser  Lys 
    1175                 1180                 1185     


<210>  1201
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1201

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Gly Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Gly Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Tyr Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Ser Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Glu 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Thr Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Lys Ile Leu Lys Tyr Thr Glu Ser Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Ala Phe Ser Asp Gln Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Val Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Lys 
        915                 920                 925             


Lys Tyr Glu Lys Ala Ile Arg Asn Ile Gln Gln Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Ser Leu Leu Leu 
945                 950                 955                 960 


Arg Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Asp 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Asn Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Ser Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asp  Thr Glu Lys Ile Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Glu Leu  Lys Lys Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  Asn Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Thr Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Glu Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Lys  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  1202
<211>  1174
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1202

Met Gly Ser Gly Lys Tyr Arg Ile Thr Lys Ile Ala Arg Lys Trp Asp 
1               5                   10                  15      


Lys Asn Trp Glu Lys Ile Ile Leu Lys Arg Ile Val Gly Asp Lys Lys 
            20                  25                  30          


Ile Lys Tyr Val Asn Glu Asn Asn Asn Lys Asp Val Asp Ile Thr Asp 
        35                  40                  45              


Thr Tyr Tyr Asn Ile Leu Ser Lys Asn Asn Ser Lys Phe Leu Gly Ser 
    50                  55                  60                  


Lys Glu Gln Phe Ile Phe Lys Val Asn Lys Met Lys Arg Asn Ile Lys 
65                  70                  75                  80  


Asn Asp Cys Val Ile Ile Lys Asp Tyr Thr Glu Glu Glu Phe Glu Lys 
                85                  90                  95      


Phe Glu Glu Asn Asn Asn Lys Ile Phe Lys Lys Ser Ile Ile Val Lys 
            100                 105                 110         


Glu Gln Gly Lys Asp Val Glu Lys Glu Lys Ile Cys Arg Asn Phe Tyr 
        115                 120                 125             


Lys Asp Glu Arg Glu Ile Met Lys Lys Arg Leu Lys Glu Ala Lys Asn 
    130                 135                 140                 


Phe Ser Asn Ile Ile Phe Asn Ile Cys Asn Lys Ile Phe Lys Leu Glu 
145                 150                 155                 160 


Tyr Leu Asp Tyr Thr Asp Glu Lys Val Tyr Glu Ile Phe Gln Asn Glu 
                165                 170                 175     


Ile Lys Val Lys Asp Val Lys Asn Leu Lys Glu Ala Phe Lys Gln Gln 
            180                 185                 190         


Glu Lys Gly Leu Glu Thr Asp Lys Leu Leu Ala Ile Ser Phe Asn Lys 
        195                 200                 205             


Lys Arg Asn Asn Ile Leu Leu Glu Phe Ile Gln Gln Ile Ala Lys Gln 
    210                 215                 220                 


Glu Phe Glu Asn Gln Lys Glu Leu Glu Asn Trp Phe Ser Tyr Gly Gly 
225                 230                 235                 240 


Glu Lys Tyr Cys Lys Glu Ile Phe Lys Ile Tyr Ser Asn Met Ser Gln 
                245                 250                 255     


Lys Glu Lys Tyr Phe Lys Leu Leu Gly His Arg Asn Gln Gly Ile Ala 
            260                 265                 270         


Ser Ile Tyr Asp Glu Lys Lys Glu Thr Leu Gln Arg Arg Leu Lys Leu 
        275                 280                 285             


Gly Asp Tyr Ser Lys Tyr Asp Leu Lys Arg Tyr Tyr Gln Lys Asp Tyr 
    290                 295                 300                 


Lys Glu Glu Ala Ile Gln Glu Leu Lys Asp Lys Ser Lys Glu Glu Leu 
305                 310                 315                 320 


Glu Lys Glu Ile Glu Asp Ile Ile Lys Glu Asn Tyr Lys Ile Asp Glu 
                325                 330                 335     


Leu Cys Gly Glu Ile Ser Asn Leu Glu Phe Ser Phe Val Asp Ser Lys 
            340                 345                 350         


Lys Glu Asn Lys Asp Lys Met Ser Glu Ile Ile Val Lys Ile Lys Glu 
        355                 360                 365             


His Tyr Lys Lys Asn Val Asn Val Glu Lys Glu Leu Lys Asn Lys Glu 
    370                 375                 380                 


Lys Tyr Ile Leu Ser Leu Ile His Asn Tyr Val Lys Gly Arg Tyr Arg 
385                 390                 395                 400 


Lys Cys Leu Glu Leu Gln Gln Lys Glu Asn Val Asp Phe Glu Asn Leu 
                405                 410                 415     


Gly Lys Arg Ile Lys Glu Ile Phe Asp Ser Asn Glu Val Thr Lys Lys 
            420                 425                 430         


Leu Lys Lys Ser Ile Ile Asn Lys Val Asn Ser Tyr Lys Ile Phe Glu 
        435                 440                 445             


Met Lys Phe Gln Asn Pro Asn Ile Glu Ser Ser Asp Asp Leu Glu Ile 
    450                 455                 460                 


Leu Lys Ala Glu Glu Thr Phe Leu Asn Lys Leu Ser Thr Ala Val Ser 
465                 470                 475                 480 


Lys Val Gly Tyr Thr Leu Asn Ile Leu Leu Glu Val Ser Ser Glu Lys 
                485                 490                 495     


Asp Ile Leu Glu Asn Tyr Asn Met Val Gly Glu Leu Cys Asn Asn Asn 
            500                 505                 510         


Ser Thr Thr Glu Ile Tyr Lys Val Tyr Pro Glu Leu Glu Lys Asn Glu 
        515                 520                 525             


Lys Leu Leu Gln Gly Met Ile His Phe Ile Gln Gly Leu Arg Gln Gln 
    530                 535                 540                 


Ser Leu His Pro Lys Ile Leu Trp Asn Phe Glu Thr Lys Asn Leu Lys 
545                 550                 555                 560 


Pro Glu Lys Leu Glu Arg Leu Lys Glu Lys Lys Ser Ile Lys Met Arg 
                565                 570                 575     


Asp Cys Val Val His Glu Asp Ser Leu Asp Lys Lys Glu Lys Asn Glu 
            580                 585                 590         


Val Glu Ile Lys Lys Tyr Phe Glu Lys Ile Glu Glu Lys Leu Pro Asn 
        595                 600                 605             


Tyr Phe Ile Glu Lys Tyr Glu Ser Asn Asn Val Phe Asn Ile Tyr Arg 
    610                 615                 620                 


Asn Phe Ile Asp Lys Ile Met Glu Val Val Lys Asn Phe Asn Phe Lys 
625                 630                 635                 640 


Glu Asn Asn Thr Ile Asp Tyr Leu Phe Pro Lys Phe His Lys Ile Tyr 
                645                 650                 655     


Lys Arg Met Cys Lys Ser Glu Asn Ile Asp Asp Arg Gln Asn Gly Ala 
            660                 665                 670         


Arg Lys Tyr Leu Leu Gln Thr Ile Tyr Tyr Tyr Tyr Phe Gln Tyr Glu 
        675                 680                 685             


Ile Glu Asn Asp Lys Asn Asn Met Ser Lys Tyr Leu Asn Leu Tyr Lys 
    690                 695                 700                 


Asn Lys Ile Lys Val Lys Lys Ile Ser Tyr Ser Tyr Ile Ile Asp Asn 
705                 710                 715                 720 


Lys Ala Val Asn Asn Lys Asn Ile Glu Ile Leu Tyr Arg Asn Ile Gln 
                725                 730                 735     


Arg Glu Gly Met Leu Asn Asn Arg Leu Ser Gln Met Asn Asn Glu Trp 
            740                 745                 750         


Ile Glu Phe Ile Val Val Gln Phe Ser Glu Phe Leu Thr Asn Lys Lys 
        755                 760                 765             


Leu Asn Trp Ile Leu Asp Asp Leu Ser Glu Tyr Lys Lys Lys Glu Lys 
    770                 775                 780                 


Leu Asp Glu Asn Asn Lys Asn Lys Leu Leu Lys Ile Leu Lys Gln Lys 
785                 790                 795                 800 


Met Asn Lys Lys Ile Thr Tyr Ser Asn Asp Ser Tyr Val Phe Ile Ser 
                805                 810                 815     


Leu Thr Gln Phe Leu Asp Leu Lys Glu Ile Ser Asn Leu Ile His Asp 
            820                 825                 830         


Ile Lys Lys Phe Ile Gln Phe Arg Glu Lys Asn Val Ser Lys Tyr Lys 
        835                 840                 845             


Pro Glu Lys Asn Lys Leu Tyr Ile Glu Glu Leu Arg Lys Ile Leu Tyr 
    850                 855                 860                 


Ile Ser Lys Val Val Leu Glu His Lys Glu Arg Val Met Gln Lys His 
865                 870                 875                 880 


Tyr Leu Glu Ser Tyr Asp Glu Asp Ile Ser Ile Met Tyr Gly Lys Gly 
                885                 890                 895     


Ile Glu Lys Lys Asp Ile Lys Asp Ile Glu Ile Lys Ile Lys Asn Lys 
            900                 905                 910         


Asn Gln Glu Val Ile Asn Gln Pro Leu Tyr Lys Ser Gly Asn Asp Glu 
        915                 920                 925             


Asn Asn Ser Trp Ile Ile Leu Tyr Gly Ile Glu Gln Ala Lys Arg Asn 
    930                 935                 940                 


Gly Thr Phe Lys Phe Phe Glu Gly Phe Phe Asn Leu Asn Asp Asp Ile 
945                 950                 955                 960 


Lys Leu Cys Lys Glu Asp Ile Glu Lys Tyr Glu Lys Leu Tyr Asn Glu 
                965                 970                 975     


Lys Glu Glu Asn Gln Lys Lys Val Asp Glu Tyr Ile Ser Lys Leu Asn 
            980                 985                 990         


Asn Asp Ile Glu Lys Ile Asn Asn  Asp Asn Asn Asp Ile  Asn Ile Glu 
        995                 1000                 1005             


Lys Thr  Asn Asn Asn Lys Gln  Leu Phe Tyr Tyr Tyr  Lys Asn Met 
    1010                 1015                 1020             


Ile Tyr  Gly Asp Gly Leu Lys  Lys Gly Tyr Asp Phe  Ile Asn Asp 
    1025                 1030                 1035             


Ile Tyr  Ser His Tyr Leu Ser  Trp Ala Tyr Arg Ile  Glu Arg Asp 
    1040                 1045                 1050             


Tyr Ser  Ile Tyr Lys Val Glu  Ala Tyr Asn Gly Lys  Ile Lys Asn 
    1055                 1060                 1065             


Phe Arg  Asn Glu Val Ala His  Phe Asn Tyr Phe Gln  Lys Thr Asp 
    1070                 1075                 1080             


Lys Ser  Leu Leu Asp Leu Leu  Asn Asp Phe Tyr Ser  Ile Phe Asp 
    1085                 1090                 1095             


Tyr Asn  Leu Lys Tyr Gln Arg  Asp Val Gln Lys Val  Ile Asn Asn 
    1100                 1105                 1110             


Ile Phe  Glu Lys Tyr Gln Val  Ile Arg Glu Asp Gly  Gly Ser Val 
    1115                 1120                 1125             


Ile Phe  Tyr Cys Lys Ile Glu  Lys Lys Leu Lys Leu  Ser Glu Asn 
    1130                 1135                 1140             


Ile Ile  Pro Lys Lys His Leu  Lys Tyr Pro Glu Ile  Lys Leu Ile 
    1145                 1150                 1155             


His Glu  Lys Tyr Val Glu Phe  Phe Arg Lys Leu Phe  Glu Tyr Lys 
    1160                 1165                 1170             


Lys 
    


<210>  1203
<211>  1331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1203

Leu Asn Thr Asn Asn Lys Asp Lys Asn Asn Ile Asn Asn Glu Asp Phe 
1               5                   10                  15      


Val Asn Gln Phe Ile Glu Tyr Lys Thr Asn Asn Asp Ile Phe Lys Lys 
            20                  25                  30          


Phe Thr Arg Lys Phe His Met Gly Asn Ile Leu Phe Lys Leu Lys Ala 
        35                  40                  45              


Lys Glu Ser Lys Asn Lys Ala Val Leu Glu Ile Arg Asn Tyr Ser His 
    50                  55                  60                  


Phe Leu Glu Thr Glu Lys Ala Val Leu Glu Ile Glu Ile Tyr Gln Gln 
65                  70                  75                  80  


Ser Glu Lys Leu Ile Glu Glu Glu Asn Ile Thr Lys Lys Asp Ile Ile 
                85                  90                  95      


Asp Lys Ala Ile Lys Glu Lys Ile Thr Glu Asp Ser Asn Glu Ile Lys 
            100                 105                 110         


Met Gln Val Lys Leu Lys Glu Asn Lys Ser Lys Glu Ile Lys Ile Ser 
        115                 120                 125             


Ile Asn Lys Glu Thr Glu Glu Tyr His Ile Lys Leu Lys Ser Ile Asn 
    130                 135                 140                 


Asn Asp Glu Leu Asn Leu Lys Arg Glu Ile Tyr Glu Ile Leu Lys Ser 
145                 150                 155                 160 


Ile Asn Ala Asn Leu Tyr Ile Ile Thr Lys Asn Ala Ile Ser Asn Ala 
                165                 170                 175     


Asp Phe Lys Lys Arg Asn Tyr Glu Asn Phe Leu Arg Glu Asn Ile Met 
            180                 185                 190         


Glu His Leu Lys Lys Asn Ile Gly Glu Lys Ser Lys Ile Thr Phe Leu 
        195                 200                 205             


Lys Ser Leu Ser Asn Ser Leu Lys Lys Leu Gln Gly Asn Ile Lys Glu 
    210                 215                 220                 


Asn Asp Glu Ile Ile Asn Phe Ile Lys Tyr Tyr Ser Asn Ile Asn Gly 
225                 230                 235                 240 


Cys Lys Thr Val Ser Glu Asn Lys Lys Asn Phe Leu Glu Lys Ile Leu 
                245                 250                 255     


Asn Thr Glu Val Ser Val Ser Glu Asn Asp Ile Ile Asp Phe Ile Ile 
            260                 265                 270         


Gly Glu Leu Lys Phe Tyr Gly Ile Ile Lys Arg Ile Glu Lys Leu Gln 
        275                 280                 285             


Glu Lys Thr Ala Asp Arg Thr Asp Glu Asp Ile Glu Asn Thr Tyr Ile 
    290                 295                 300                 


Glu Ser Tyr Val Leu Leu Asp Lys His Glu Lys Phe Lys Lys Tyr Asn 
305                 310                 315                 320 


Arg Asn Lys Lys Asp Glu Ile Val Lys Leu Phe Val Lys Asp Ile His 
                325                 330                 335     


Asn Asp Lys Met Glu Glu Lys Ile Asn Gln Ile Leu Ser Lys Phe Lys 
            340                 345                 350         


Ile Lys Glu Leu Thr Lys Lys Leu Glu Lys Asn Thr Glu Asn Lys Asn 
        355                 360                 365             


Phe Asp Thr Glu Ile Phe Gly Ile Phe Lys Lys His Tyr Lys Val Asn 
    370                 375                 380                 


Phe Asp Ser Lys Lys Phe Glu Asn Lys Ser Asp Glu Glu Lys Glu Leu 
385                 390                 395                 400 


Tyr Lys Ile Ile Tyr Arg Tyr Leu Lys Gly Arg Ile Glu Lys Ile Leu 
                405                 410                 415     


Ile Asn Glu Glu Lys Ile Lys Thr Lys Glu Leu Lys Ile Asn Lys Ile 
            420                 425                 430         


Leu Asp Glu Lys Lys Leu Ser Glu Lys Val Leu Lys Arg Val Lys Gln 
        435                 440                 445             


Tyr Thr Leu Glu His Ile Met Tyr Leu Gly Lys Leu Arg His Asn Asp 
    450                 455                 460                 


Ile Val Lys Ile Thr Val Asn Thr Asp Asp Phe Ser Arg Leu His Ala 
465                 470                 475                 480 


Lys Glu Glu Leu Asp Leu Glu Leu Ile Thr Phe Phe Ala Ser Thr Asn 
                485                 490                 495     


Met Glu Leu Asn Lys Ile Phe Glu Ile Asn Lys Glu Lys Asn Asp Phe 
            500                 505                 510         


Phe Gly Asp Ser Phe Lys Ile Asn Asp Thr Lys Val Leu Leu Lys Asn 
        515                 520                 525             


Glu Val Thr Ser Ser Lys Leu Tyr Ile Leu Lys Asn Leu Asn Phe Ile 
    530                 535                 540                 


Asp Asn Glu Asn Lys Val Lys Lys Glu Glu Phe Ile Ser Lys Phe Ile 
545                 550                 555                 560 


Thr Ile Gly Val Asn Glu Arg Asn Arg Ile Leu His Ala Asn Thr Lys 
                565                 570                 575     


Glu Ile Ala Leu Lys Gly Lys Gln Asp Asn Tyr Asp Lys Val Ile Asn 
            580                 585                 590         


Ile Ile Lys Asn Leu Lys Ile Ser Asp Glu Glu Val Ser Lys Ala Leu 
        595                 600                 605             


Asn Leu Asp Val Val Phe Lys Asn Lys Lys Asp Ile Ile Thr Lys Ile 
    610                 615                 620                 


Asn Asp Ile Arg Ile Ser Glu Glu Asn Ser Asn Asp Ile Lys Tyr Leu 
625                 630                 635                 640 


Pro Ser Phe Ser Lys Ile Leu Pro Glu Ile Leu Asn Leu Tyr Arg Asn 
                645                 650                 655     


Asn Pro Lys Asn Glu Pro Phe Asp Thr Ile Glu Thr Glu Lys Ile Val 
            660                 665                 670         


Leu Asn Ala Leu Ile Tyr Val Asn Lys Glu Leu Tyr Lys Lys Leu Ile 
        675                 680                 685             


Leu Glu Asp Asp Leu Gln Glu Asn Arg Ser Lys Asn Ile Phe Leu Gln 
    690                 695                 700                 


Glu Leu Lys Lys Thr Leu Gly Gly Thr Asp Glu Ile Asp Glu Asn Ile 
705                 710                 715                 720 


Ile Glu Asn Tyr Tyr Lys Asn Ala Gln Ile Ser Ala Ser Lys Gly Asn 
                725                 730                 735     


Asn Lys Ala Ile Lys Lys Tyr Gln Lys Lys Ile Ile Glu Cys Tyr Ile 
            740                 745                 750         


Glu Tyr Leu Arg Lys Asn Tyr Glu Lys Gln Thr Ser Asp Lys Ser Ile 
        755                 760                 765             


Val Ile Asn Asn Asp Phe Glu Tyr Ile Ile Ser Ile Phe Ala Leu Leu 
    770                 775                 780                 


Asn Asn Asn Ile Val Ile Asn Lys Ile Arg Asn Arg Phe Phe Ala Thr 
785                 790                 795                 800 


Ser Val Trp Leu Asn Thr Ser Glu Tyr Gln Asn Ile Ile Asp Ile Leu 
                805                 810                 815     


Asp Glu Ile Met Gln Ile Asn Ile Leu Lys Ser Glu Tyr Ile Thr Ser 
            820                 825                 830         


Asn Trp Lys Glu Asn Leu Glu Glu Phe Ile Arg Lys Thr Lys Asn Lys 
        835                 840                 845             


Glu Ile Glu Leu His Gln Ser Lys Lys Glu Phe Phe Asp Asn Asn Tyr 
    850                 855                 860                 


Lys Glu Ile Lys Lys Asp Met Ile Val Lys Ile Asn Asp Asn Lys Ile 
865                 870                 875                 880 


Gln Lys Ile Leu Asn Lys Tyr Leu Lys Glu Ile Thr Gly Phe Ser Ser 
                885                 890                 895     


Asn Asn Glu Tyr Met Phe Lys Asn Leu Gly Lys Leu Thr Leu Glu Glu 
            900                 905                 910         


Arg Asp Phe Ile Leu Ser Asn Lys Asn Asn Lys Lys Leu Ile Glu Lys 
        915                 920                 925             


Asn Ile Asp Glu Ile Ile Gly Glu Lys Leu Asp Ala Ile Lys Glu Lys 
    930                 935                 940                 


Ile Leu Leu Arg Lys Val Phe Ser Ser Lys Phe Leu Glu Lys Tyr Lys 
945                 950                 955                 960 


Lys Glu Ile Asp Asn Leu Val Glu Ser Thr Glu Ser Lys Asn Glu Asn 
                965                 970                 975     


Lys Phe Glu Lys Ile Tyr Tyr Pro Lys Glu His Lys Asn Glu Leu Tyr 
            980                 985                 990         


Ile Tyr Lys Lys Asn Leu Phe Leu  Asn Ile Gly Asn Pro  Asn Phe Asp 
        995                 1000                 1005             


Lys Ile  Tyr Gly Leu Ile Ser  Lys Asp Ile Lys Asn  Val Asp Thr 
    1010                 1015                 1020             


Lys Ile  Leu Phe Asp Asp Asp  Ile Arg Lys Asn Lys  Ile Ser Glu 
    1025                 1030                 1035             


Ile Asp  Ala Ile Leu Lys Asn  Leu Asn Asp Lys Leu  Asn Gly Tyr 
    1040                 1045                 1050             


Ser Asn  Asp Tyr Lys Ala Lys  Tyr Val Asn Lys Leu  Lys Glu Asn 
    1055                 1060                 1065             


Asp Asp  Phe Phe Ala Lys Asn  Ile Gln Asn Glu Asn  Tyr Ser Ser 
    1070                 1075                 1080             


Phe Gly  Glu Phe Glu Lys Asp  Tyr Asn Lys Val Ser  Glu Tyr Lys 
    1085                 1090                 1095             


Lys Ile  Arg Asp Leu Val Glu  Phe Asn Tyr Leu Asn  Lys Ile Glu 
    1100                 1105                 1110             


Ser Tyr  Leu Ile Asp Ile Asn  Trp Lys Leu Ala Ile  Gln Met Ala 
    1115                 1120                 1125             


Arg Phe  Glu Arg Asp Met His  Tyr Ile Val Asn Gly  Leu Arg Glu 
    1130                 1135                 1140             


Leu Gly  Ile Ile Lys Leu Asn  Gly Tyr Asn Thr Gly  Ile Ser Arg 
    1145                 1150                 1155             


Ala Tyr  Pro Lys Arg Asn Gly  Ser Gly Asp Phe Tyr  Ala Thr Thr 
    1160                 1165                 1170             


Ala Tyr  Tyr Lys Phe Phe Asp  Glu Glu Ser Tyr Lys  Lys Phe Glu 
    1175                 1180                 1185             


Lys Ile  Cys Tyr Gly Phe Gly  Ile Asp Leu Ser Glu  Asn Ser Glu 
    1190                 1195                 1200             


Ile Asn  Lys Pro Glu Asn Lys  Ser Ile Arg Asn Tyr  Ile Ser His 
    1205                 1210                 1215             


Phe Tyr  Ile Val Arg Asn Pro  Phe Val Asp Tyr Ser  Ile Ala Glu 
    1220                 1225                 1230             


Gln Ile  Asp Arg Val Ser Asn  Leu Leu Ser Tyr Ser  Thr Arg Tyr 
    1235                 1240                 1245             


Asn Asn  Ser Thr Tyr Ala Ser  Val Phe Glu Val Phe  Lys Lys Asp 
    1250                 1255                 1260             


Val Asn  Leu Asp Tyr Asp Lys  Leu Lys Thr Lys Phe  Lys Leu Phe 
    1265                 1270                 1275             


Asp Asp  Glu Lys Asn Asp Asp  Ile Lys Ile Leu Lys  Ile Glu Asp 
    1280                 1285                 1290             


Leu Ile  Glu Ser Lys Lys Val  Ser Val Leu Glu Leu  Glu Ser Tyr 
    1295                 1300                 1305             


Asn Ser  Asp Tyr Val Lys Asn  Leu Ile Ile Glu Leu  Leu Thr Lys 
    1310                 1315                 1320             


Ile Glu  Asn Thr Asn Asp Thr  Leu 
    1325                 1330     


<210>  1204
<211>  949
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1204

Met Pro His Gln Lys Lys Met Ala Glu Arg Ile Lys Phe Val Asn Tyr 
1               5                   10                  15      


Gly Tyr Tyr Leu Arg Leu Lys Lys Asn Cys Ala Asp Ser Phe Glu Tyr 
            20                  25                  30          


Tyr Trp Cys Asp Tyr Ile Lys Glu Phe Ile Glu Glu Asn Tyr Val Thr 
        35                  40                  45              


Lys Ile Lys Glu Ala Lys Gly Lys Asn Gly Arg Gln Leu Thr Glu Glu 
    50                  55                  60                  


Asn Cys Asn Ser Glu Ala Met Leu Ser Lys Cys Trp His Asp Met Ile 
65                  70                  75                  80  


Arg His Met Cys Ala Lys Tyr Met Asp Leu Gly Lys Ala Val Tyr His 
                85                  90                  95      


Phe Met Leu Pro Gly Lys Ala Glu Gly Asn Asp Leu Cys Leu Asp Arg 
            100                 105                 110         


Leu Asn Asp Ser Phe Ser Lys Gly Ile Thr Ser Phe Asp Tyr Glu Asn 
        115                 120                 125             


Ile Lys Ala Glu Glu Asn Leu Gln Lys Ala Met Phe Gly Val Leu Val 
    130                 135                 140                 


Ser Gly Thr Phe Asn Phe Ser Arg Ser Val Ala Asp Tyr Ser Gly Pro 
145                 150                 155                 160 


Ala Ala Ala Lys Leu Ala Lys Glu Leu Arg Ala Glu Gly Lys Thr Leu 
                165                 170                 175     


Asn Glu Asp Val Leu Met Val Asp Glu Ala His Leu Lys Ala Ile Leu 
            180                 185                 190         


Tyr Ser Asp Ala Lys Arg Lys Leu Leu Arg Tyr Phe Gly Gly Ser Ser 
        195                 200                 205             


Ala Cys Glu Ala Leu Gly Leu Asp Lys Asp Lys Met Val Leu Glu Phe 
    210                 215                 220                 


Arg Gln Ile Phe Arg Gly Leu Arg Asn Ser Ala Phe His Tyr Thr Asp 
225                 230                 235                 240 


Gly Lys Lys Ala Asp Ile Lys Phe Asp Val Thr Arg Gln Leu Trp Ile 
                245                 250                 255     


Gln Asp Val Gln Ala Asn Lys Gln Leu Ile Leu Asp Lys Tyr Tyr Ser 
            260                 265                 270         


Asn Asn Val Cys Arg Tyr Tyr Lys Pro Glu Met Val Lys Lys Leu Ile 
        275                 280                 285             


Gly Asn Leu Tyr His Gly Tyr Val Glu Gln Glu Ala Gln Ile Pro Ala 
    290                 295                 300                 


Phe Arg Thr Val Trp Lys Arg Lys Asp Phe Ala Lys Tyr Leu Asn Asp 
305                 310                 315                 320 


Ser Asn Phe Leu Pro Val Asn Ile Lys Asn Asp Val Lys Glu Arg Thr 
                325                 330                 335     


Val Phe Glu Gly Ala Leu Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg 
            340                 345                 350         


Lys Tyr Thr Val Gly Gln Asp Ala Pro Lys Tyr Phe Phe Glu Ala Val 
        355                 360                 365             


Arg Ala Tyr Ser Asp Glu His Ala Lys Asn Lys Gln Asp Pro Tyr Ala 
    370                 375                 380                 


Asn Gln Ala Lys Asn Phe Trp Asp Tyr Val Glu Lys Leu Gln Lys Ser 
385                 390                 395                 400 


Tyr Glu Lys Gly Thr Leu Thr Phe Gly Ala Val Cys Gln Thr Ile Met 
                405                 410                 415     


Thr Glu Phe Val Gln Gln Asn Ser Lys Ala Thr Glu Lys Glu Gly Glu 
            420                 425                 430         


Ile Tyr Gln His Phe Lys Val Leu Phe Pro Leu Cys Met Gln Arg Gly 
        435                 440                 445             


Phe Glu Lys Tyr Val Lys Glu Lys His Gly Tyr Leu Leu Lys Pro Trp 
    450                 455                 460                 


Leu Asp Thr Val Val Arg Glu Asn Val Leu Gln Asp Ala Ala Ile Thr 
465                 470                 475                 480 


Cys Phe Asp Asp Leu Met Arg Asp Ala Glu Asp Arg Glu Tyr Ser Trp 
                485                 490                 495     


Tyr Val Val Ala His Phe Ile His Pro Lys Lys Leu Asn His Phe Val 
            500                 505                 510         


Gly Ala Leu Lys Asp Tyr Leu Gln Phe Lys Gln Asp Ile Phe Arg Arg 
        515                 520                 525             


Cys Ser Phe Ala Asn Ile Tyr Ser Glu Gly Glu Leu Ser Gln Lys Lys 
    530                 535                 540                 


Ala Met Leu Ala Glu Lys Glu Ala Glu Ile Ser Glu Ile Leu Arg Val 
545                 550                 555                 560 


Met Glu Phe Val Arg Gly Ile Thr Gly Arg Val Ser Lys Thr Phe Ser 
                565                 570                 575     


Asp Tyr Tyr Glu Asn Glu Glu Val Tyr Ala Asn Tyr Leu Gly Lys Tyr 
            580                 585                 590         


Ile Asp Phe Pro Lys Thr Asp Gly Ile Ser Val Phe Glu Ser Phe Arg 
        595                 600                 605             


Asp Phe Cys Thr Asn Thr Leu Pro Asp Gly Asn Val Leu Asp Val Tyr 
    610                 615                 620                 


Met Asp Glu Lys Asn Pro Arg Leu Leu Lys Asn Val Glu Leu Ala Arg 
625                 630                 635                 640 


Met Tyr Ala Gly Gly Asp Val Ala Leu Lys Lys Arg Lys Arg Ile Thr 
                645                 650                 655     


Ala Lys Asp Leu Gln Arg Tyr Tyr Gly Asn Glu Val Ala Val Gln Lys 
            660                 665                 670         


Ile Leu Gln Lys Gly Leu Cys Ser Thr Arg Glu Glu Gln Gln Arg Val 
        675                 680                 685             


Leu Glu Gln Gln Asn Leu Arg Gly Arg Ile Thr Leu Asn Asp Val Thr 
    690                 695                 700                 


Glu Ile Gln Glu Ile Ile Ser Asp Met Leu Ser Gln Leu Val Thr Phe 
705                 710                 715                 720 


Ser Tyr Phe Arg Glu Arg Asp Gln Met Tyr Leu Leu Leu Gly Phe Tyr 
                725                 730                 735     


Tyr Met Ala Leu Gln Thr Asn Arg Gly Ser Ser Trp Gly Asn Glu Thr 
            740                 745                 750         


Ile Asp Phe Cys Ala Gly Lys Lys Ile Ser Ile Lys Gln Gly Trp Val 
        755                 760                 765             


Leu His Gln Val Arg Ser Val Phe Thr Tyr Gly Leu Lys Leu Tyr Ser 
    770                 775                 780                 


Glu Leu Asp Glu Lys Gly Val Gly Gly Gln Leu Ser Ser Lys Ile Val 
785                 790                 795                 800 


Ala Phe Glu Arg Val His Arg Thr Ser Leu Ala Cys Ala Leu Arg Leu 
                805                 810                 815     


Phe Met Asp Glu Asn Cys Ser Arg Arg Ala Val Asp Val Arg Asn Tyr 
            820                 825                 830         


Val Asp His Phe Lys Tyr Tyr Phe Lys Ala Asp Arg Ser Ile Met Glu 
        835                 840                 845             


Leu Tyr Ser Ala Tyr Tyr Asp Cys Phe Phe Asp Tyr Ser Thr Lys Met 
    850                 855                 860                 


Arg Lys Ser Val Leu Leu Asn Phe Ile Ser Ile Leu Glu Arg His Phe 
865                 870                 875                 880 


Val Val Ser Lys Leu Arg Val Asn Cys Leu Glu Glu Arg Cys Ser Val 
                885                 890                 895     


Ser Phe Ala Glu Ser Leu Lys Ser Glu Lys Phe Thr Tyr Lys Leu Glu 
            900                 905                 910         


Ala Asp Ala Asn Lys Lys Ser Lys Glu Gln Thr Val Glu Phe Pro Ala 
        915                 920                 925             


Arg Asp Lys Glu Phe Leu Glu Ser Leu Gln Ala Glu Leu Glu Tyr Lys 
    930                 935                 940                 


Glu Gly Tyr Asn Ser 
945                 


<210>  1205
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1205

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Gly Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  1206
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1206

Met Lys Leu Thr Gln Ser Arg Gln Ser Lys Gly Ala Gln Phe Phe Arg 
1               5                   10                  15      


Asp Val Ser Lys Gly Gln Leu Val Leu Asn Asn Asn Ile Asp Asn Thr 
            20                  25                  30          


Asp Asn Val Ile Gln Ser Leu Pro Tyr Glu Lys Ser Tyr Ile Gly Arg 
        35                  40                  45              


Ile Leu Tyr Lys Ser Ser Asn Ser Asp Lys Asp Asn Asp Gln Asn Pro 
    50                  55                  60                  


Phe Asn Ser Phe Val Arg Gln Leu Val Lys Asn Gln Asn Lys Glu Arg 
65                  70                  75                  80  


Lys Leu Thr Ser Tyr Ile Asn Leu Asn Asp Lys Asn Asn Lys Lys Leu 
                85                  90                  95      


Ser Lys Asp Asp Phe Lys Asn Gln Ile Asn Thr His Leu Ser Phe Tyr 
            100                 105                 110         


Gly Arg Asn Leu Lys Val Asp Ala Asp Ser Pro Thr Leu Lys Glu Ile 
        115                 120                 125             


Leu Leu Gln Tyr Tyr Asp Gly Asn Asn Asp Ala Glu Asn Glu Leu Lys 
    130                 135                 140                 


Lys Leu Ala Asn Tyr Ile Ser Asn Leu Ala Lys Lys Lys Thr Glu Lys 
145                 150                 155                 160 


Leu Lys Lys Ser Ile Lys Asn Asn Lys Ile Pro Phe Glu Pro Asp Gly 
                165                 170                 175     


Glu Lys Leu Lys Leu Thr Ser Asp Lys Met Lys Leu Leu Phe Asp Phe 
            180                 185                 190         


Leu Lys Lys Asp Gly Val Glu Leu Thr Ser Tyr Glu Lys Phe Gln Lys 
        195                 200                 205             


Asp Tyr Lys Phe Ser Asp Leu Ala Asn Lys Ile Glu Ser Ile Ile Ser 
    210                 215                 220                 


Asn Asp Lys Asn Ser Val Asp Lys Lys Pro Phe Pro Thr Lys Lys Ile 
225                 230                 235                 240 


Tyr Gln Thr Val Ser Asp Tyr Asp Tyr Asp Phe Arg Lys Lys Asn Glu 
                245                 250                 255     


Asp Asn Asp Leu Tyr Leu Phe Tyr Ala Lys Glu Val Lys Asn Tyr Phe 
            260                 265                 270         


Lys Arg Leu Phe Ile Asp Lys Lys Leu Ser Lys Lys Gln Tyr Glu Glu 
        275                 280                 285             


Ile Lys Ser Gln Asn Tyr Lys Ser Glu Lys Tyr Ile Phe Gly Gln Val 
    290                 295                 300                 


Lys Arg Tyr Ile Ile Asn Gln Leu Val Gln Gly Leu Ile Leu Tyr Gly 
305                 310                 315                 320 


Lys Ile Met His Tyr Cys Tyr Asp Thr Asp Ala Lys Gln Phe Asn Val 
                325                 330                 335     


Glu Ile Asn Ser Asp Thr Leu Thr Tyr Ile Gln Val Glu Glu Ala Phe 
            340                 345                 350         


Lys Lys Gln Ile Tyr Leu Ser Leu Ser Trp Ala Ile Thr Arg Leu Asn 
        355                 360                 365             


Tyr Phe Phe Asn Tyr Gly Ser Gln Asn Glu Glu Asn Leu Asp Lys Asp 
    370                 375                 380                 


Lys Lys Glu Gly Asp Ile Leu Leu Ala Lys Thr Phe Arg Asp Lys Phe 
385                 390                 395                 400 


Tyr Glu Lys Val Phe Asn Asn Asn Glu Lys Asp Asp Asp Gly Ile Ser 
                405                 410                 415     


Pro Lys Asp Glu Leu Tyr Ala Lys Ile Ser Thr Cys Phe Ala Ile Asn 
            420                 425                 430         


Ser Lys Asp Asn Asn Asp Asp Asp Ile Lys Lys Leu Leu Glu Asp Cys 
        435                 440                 445             


Cys Ser Ser Val Ala Asn Ile Arg His Asn Val Phe His Phe Lys Lys 
    450                 455                 460                 


Glu Asn Ile Phe Glu Ile Leu Glu Glu Ile Lys Leu Asp Ser Gln Ile 
465                 470                 475                 480 


Ser Lys Glu Leu Leu Asn Arg Asp Ile Leu Asn Ile Gln Lys Cys Phe 
                485                 490                 495     


Lys Glu Gln Ile Arg Ser Thr Ala Leu Thr Asp Tyr Tyr Ser Phe Glu 
            500                 505                 510         


Leu Leu Glu Lys Val Phe Lys Asn Glu Lys Leu Glu Phe Phe Leu Tyr 
        515                 520                 525             


Ser Ser Gln Tyr Pro Met Met Pro Ser Phe Lys Lys Ile His Lys Arg 
    530                 535                 540                 


Gly Cys Asn Ile Ser Lys Ser Pro Asn Gln Thr Lys Glu Ile Lys Trp 
545                 550                 555                 560 


Leu Ile Glu Leu Asp Ser Glu Ile Asp Asn Glu Gly Lys Leu Ala Tyr 
                565                 570                 575     


Lys Asn Leu Leu Gln Leu Ile Tyr Tyr His Ser Phe Leu Pro Ala Ile 
            580                 585                 590         


Lys Lys Asp Glu Lys Leu Val Thr Glu Phe Ile Asn Lys Thr Lys Gln 
        595                 600                 605             


Trp Asn Lys Thr Lys Ser Ile Ala Ser Gln Lys Ala Lys Lys Ala Lys 
    610                 615                 620                 


Asn Lys Lys Ile Asn Tyr Tyr Glu Phe Lys Tyr Ser Asn Met Pro Arg 
625                 630                 635                 640 


Phe Glu Tyr Gly Ile Pro Leu Lys Asp Tyr Leu Glu Glu Leu Gln Arg 
                645                 650                 655     


Gln Gln Ser Ile Arg Glu Asn Asp Glu Asp Lys Lys Asp Lys Asp Asn 
            660                 665                 670         


Tyr Tyr Val Glu Phe Val Gln Asp Ile Phe Val Phe Ala Phe Asp Ser 
        675                 680                 685             


Tyr Leu Leu Lys Ile Ile Ser Ala Tyr Asp Cys Tyr Glu Glu Leu Ile 
    690                 695                 700                 


His Pro Lys Leu Lys Thr Lys Glu Glu Ser Lys Glu Thr Leu Glu Lys 
705                 710                 715                 720 


Leu Phe Asn Glu Ser Asn Pro Ile Leu Lys Ile Lys Thr Asn Leu Asn 
                725                 730                 735     


Pro Asp Thr Lys Phe Ile Thr Met Tyr Pro Phe Phe Arg Leu Leu Asp 
            740                 745                 750         


Gln Arg Glu Leu Asn Ile Leu Leu His Gln Phe Ile Arg Tyr Cys Ser 
        755                 760                 765             


Ser Thr Gln Lys Arg Ser Asn Thr Asn Asp Glu Thr Leu Asn Thr Leu 
    770                 775                 780                 


Thr Gln Ile Glu Glu Leu Ile Thr Leu Val Gln Phe Thr Ile Pro Leu 
785                 790                 795                 800 


Gln Thr Lys Asp Val His Phe Lys Ser Ala Met Glu Lys Tyr Phe Ser 
                805                 810                 815     


Glu Phe Phe Glu Asn Lys Asp Pro Gln Asn Tyr Asp Asp Phe Tyr Leu 
            820                 825                 830         


Gln Gly Ser Lys Lys Glu Glu Asp Lys Leu Val Lys His Arg Ser Met 
        835                 840                 845             


Ser Leu Val Ala Arg Ser Gly Ala Met Ala Leu Tyr Thr Lys Met Phe 
    850                 855                 860                 


Ser Ser Ile Tyr Gln Ile Asn Lys Ser Asp Tyr Glu Lys Tyr Lys Asp 
865                 870                 875                 880 


Ile Tyr Thr Ile Lys Asn Asn Ser Glu Val Thr Lys Ile Glu Glu Met 
                885                 890                 895     


Gln Asn Arg Leu Gln Gln Leu His Glu Lys Leu Val Arg Ile Lys Leu 
            900                 905                 910         


Ile Ser Asp Thr Gln Leu Asn Asp Ile Lys Lys Tyr Gln Thr Leu Ala 
        915                 920                 925             


Lys Gln Ile Lys Glu Tyr Glu Asn Leu Arg His Lys Leu Thr Phe Glu 
    930                 935                 940                 


Ser Leu Tyr Arg Ile His Gln Leu His Val Glu Ile Leu Gly Arg Phe 
945                 950                 955                 960 


Ala Ala Phe Ala Asn Asp Trp Glu Arg Asp Met Phe Phe Met Phe Thr 
                965                 970                 975     


Ala Leu Glu Asn Arg Gly Lys Ile Asn Phe Lys Leu Lys Pro Ile Phe 
            980                 985                 990         


Asn Arg Gly Lys Val Val Gly Asn  Leu Asn Asn Lys Leu  Lys Asp Asp 
        995                 1000                 1005             


Ala Arg  Lys Leu Phe Phe Glu  Leu Cys Trp Ser Asn  Glu Ile Tyr 
    1010                 1015                 1020             


Asp Lys  Asp Lys Asp Asp Asn  Ser Asn Gly Asp Tyr  Ile Tyr Asp 
    1025                 1030                 1035             


Arg Leu  Leu Ile Arg Asn Tyr  Cys Ala His Leu Asn  His Met Thr 
    1040                 1045                 1050             


Gln Phe  Lys Lys Asn Asn Glu  Thr Gln Pro Ser Ile  Ile Gly Tyr 
    1055                 1060                 1065             


Ile Asn  Lys Leu Arg Val Leu  Leu Ala Tyr Asp Ile  Lys Arg Gln 
    1070                 1075                 1080             


Asn Ala  Val Thr Lys Ala Val  Lys Glu Ile Leu Glu  Lys His Tyr 
    1085                 1090                 1095             


Lys Val  Lys Leu Thr Leu Lys  Arg Ser Asp Asp Asn  Pro Asp Lys 
    1100                 1105                 1110             


Phe Val  Ile Ala Asn Leu Glu  Ser Asp Glu Ile Thr  His Leu Lys 
    1115                 1120                 1125             


Asn Leu  Lys Asn Pro Val Ile  Ile Glu Asp Asn Asp  Lys Phe Met 
    1130                 1135                 1140             


Ile Ser  Leu Ile Arg Lys Leu  Leu Ile Phe Lys Phe  Glu Ser Ala 
    1145                 1150                 1155             


Asn Val  Lys 
    1160     


<210>  1207
<211>  1143
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1207

Met Arg Val Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Val Tyr Ser Gly 
            20                  25                  30          


Gln Pro Val Ser Asn Glu Thr Cys Asn Ile Leu Pro Glu Lys Lys Arg 
        35                  40                  45              


Gln Ser Phe Asp Leu Ser Ile Glu Asn Lys Thr Leu Lys Arg Arg Asp 
    50                  55                  60                  


Asp Val Asp Lys Thr Lys Lys Gly Lys Tyr Asp Ile Val Arg Lys Ile 
65                  70                  75                  80  


Ile Lys Tyr Gly Glu Leu Pro Gln Ser Ile Asn Asp Val Asp Ile Leu 
                85                  90                  95      


Glu Phe Leu Asn His Lys Phe Gln Lys Pro Val Lys Tyr Trp Lys Asn 
            100                 105                 110         


Gly Lys Glu Glu Ser Phe Asn Leu Thr Leu Leu Ile Val Glu Ala Val 
        115                 120                 125             


Lys Thr Gln Asp Arg Gln Lys Leu Gln Pro Tyr Tyr Asp Trp Lys Thr 
    130                 135                 140                 


Trp Tyr Ile Gln Thr Lys Ser Asp Leu Phe Lys Lys Ser Ile Glu Asn 
145                 150                 155                 160 


Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg Lys Lys Ala Leu 
                165                 170                 175     


Leu Ala Trp Glu Thr Glu Phe Thr Thr Ser Gly Lys Ile Asp Leu Thr 
            180                 185                 190         


His Tyr His Lys Val Tyr Met Thr Asp Val Leu Cys Thr Ala Leu Gln 
        195                 200                 205             


Lys Val Glu Pro Ser Thr Asp Lys Lys Gly Lys Ile Asn Thr Asn Ala 
    210                 215                 220                 


Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Thr His Gln Pro Ala Ile 
225                 230                 235                 240 


Phe Gly Thr Arg Gln Ala Pro Asn Asn Val Asn Arg Ala Asp Asp Arg 
                245                 250                 255     


Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu Glu His Tyr Phe 
            260                 265                 270         


Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Ala Asp Asp Ile Glu His 
        275                 280                 285             


Tyr Leu Lys Thr Gln Thr Leu Lys Thr Thr Ile Glu Lys Gln Leu Val 
    290                 295                 300                 


Asn Ala Ile Arg Ala Asn Ile Ile Gln Gln Gly Lys Thr Asn His His 
305                 310                 315                 320 


Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile Arg Ile Lys Thr 
                325                 330                 335     


Asn Glu Ala Phe Val Leu Asn Leu Thr Gly Thr Cys Ala Phe Ala Ala 
            340                 345                 350         


Asn Asn Ile Arg Asn Met Val Asp Asn Glu Gln Thr Asn Asp Ile Leu 
        355                 360                 365             


Gly Lys Gly Asp Phe Ile Lys Ser Leu Leu Lys Asp Asn Thr Asn Gly 
    370                 375                 380                 


Gln Leu Tyr Ser Phe Phe Phe Gly Glu Ser Leu Ser Thr Asn Lys Ala 
385                 390                 395                 400 


Glu Lys Glu Thr Gln Leu Trp Gly Ile Arg Gly Ala Val Gln Gln Ile 
                405                 410                 415     


Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu Lys Thr Val Phe 
            420                 425                 430         


Asn Ile Ser Asn Phe Glu Asn Pro Thr Ile Thr Asp Pro Lys Gln Gln 
        435                 440                 445             


Thr Asn Tyr Ala Asp Thr Ile Tyr Lys Ala Leu Phe Ile Lys Glu Leu 
    450                 455                 460                 


Glu Lys Ile Pro Asn Ala Phe Ala Gln Gln Leu Lys Thr Gly Gly Ala 
465                 470                 475                 480 


Leu Ser Tyr Tyr Thr Ile Glu Asn Leu Lys Ser Leu Leu Thr Thr Phe 
                485                 490                 495     


Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala Pro Gly Phe Lys 
            500                 505                 510         


Lys Val Phe Asn Gly Gly Ile Asn Tyr Gln Asn Ala Lys Gln Asp Glu 
        515                 520                 525             


Ser Phe Tyr Glu Leu Met Leu Glu Arg Tyr Leu Arg Lys Glu Asn Phe 
    530                 535                 540                 


Ala Glu Glu Ala Tyr Asn Ala Arg Tyr Phe Leu Leu Lys Leu Ile Tyr 
545                 550                 555                 560 


Asn Asn Leu Phe Leu Pro Gly Phe Thr Arg Asp Arg Lys Ala Phe Ala 
                565                 570                 575     


Asp Ser Val Gly Phe Val Gln Met Gln Asn Lys Lys Gln Ala Glu Lys 
            580                 585                 590         


Val Asn Pro Lys Lys Arg Glu Ala Tyr Ala Phe Glu Ala Val Arg Pro 
        595                 600                 605             


Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala Tyr Val Gln Ser 
    610                 615                 620                 


Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys Ala Thr Asp Glu 
625                 630                 635                 640 


Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val Phe Val Lys Gly 
                645                 650                 655     


Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe Val Gln Val Pro 
            660                 665                 670         


Gln Pro Gln Leu Thr Ala Thr Ala Ser Asn Gln Gln Lys Ala Asp Lys 
        675                 680                 685             


Leu Asn Gln Leu Glu Ala Ser Ile Thr Ala Asp Cys Lys Leu Thr Pro 
    690                 695                 700                 


Gln Tyr Ala Lys Ala Asp Asn Ala Thr His Ile Ala Phe Tyr Val Phe 
705                 710                 715                 720 


Cys Lys Leu Leu Asp Ala Gly His Leu Ser Asn Leu Arg Asn Glu Leu 
                725                 730                 735     


Ile Lys Phe Arg Glu Ser Val Asn Glu Phe Lys Phe His His Leu Leu 
            740                 745                 750         


Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val Val Pro Thr Asp 
        755                 760                 765             


Tyr Arg Asp Leu Tyr Ser Ser Glu Ala Asp Cys Leu Ala Arg Leu Arg 
    770                 775                 780                 


Pro Phe Ile Glu Gln Gly Ala Asp Ile Thr Asn Trp Ser Asp Leu Phe 
785                 790                 795                 800 


Val Gln Ser Asp Lys His Ser Pro Val Ile His Ala Asn Ile Glu Leu 
                805                 810                 815     


Ser Val Lys Tyr Gly Thr Thr Lys Leu Leu Glu Gln Ile Ile Asn Lys 
            820                 825                 830         


Asp Pro Gln Phe Lys Thr Thr Glu Ala Asn Phe Thr Ala Trp Asn Thr 
        835                 840                 845             


Ala Gln Lys Ser Ile Glu Gln Leu Ile Lys Gln Arg Glu Asp His His 
    850                 855                 860                 


Glu Gln Trp Val Lys Ala Lys Asn Ala Asp Asp Lys Glu Lys Gln Glu 
865                 870                 875                 880 


Arg Lys Arg Glu Lys Ser Asn Phe Ala Gln Lys Phe Ile Glu Lys His 
                885                 890                 895     


Gly Asp Asp Tyr Leu Asp Ile Cys Asp Tyr Ile Asn Thr Tyr Asn Trp 
            900                 905                 910         


Leu Asp Asn Lys Met His Phe Val His Leu Asn Arg Leu His Gly Leu 
        915                 920                 925             


Thr Ile Glu Leu Leu Gly Arg Met Ala Gly Phe Val Ala Leu Phe Asp 
    930                 935                 940                 


Arg Asp Phe Gln Met Leu Asp Ala Lys Arg Ile Ser Asp Leu Tyr Gln 
945                 950                 955                 960 


Leu Lys Ser Phe Ile Ser Phe Arg Glu Ile Thr Ser Glu Leu Asp Lys 
                965                 970                 975     


Asn Asn Asp Ile Thr Glu Ile Asn Leu Ile Lys Asp Lys Glu Ile Ile 
            980                 985                 990         


Lys Arg Asp Gly Thr Pro Ile Thr  Glu Ala Asp Arg Asn  Ser Leu Lys 
        995                 1000                 1005             


Ser Cys  Ile Gln Ser Lys Arg  Glu Tyr Tyr Gln Lys  Thr Tyr Phe 
    1010                 1015                 1020             


Lys Glu  His Thr Asn Pro Phe  Thr Asp Arg Asn Tyr  Ile Ala His 
    1025                 1030                 1035             


Phe Asn  Tyr Leu Ser Thr Asn  Thr Gly Asn His Ser  Leu Ile Lys 
    1040                 1045                 1050             


Leu Ile  Asn Lys Leu Arg Asp  Leu Leu His Tyr Asp  Arg Lys Leu 
    1055                 1060                 1065             


Lys Asn  Ala Val Ser Lys Ala  Phe Ile Asp Leu Phe  Asp Lys His 
    1070                 1075                 1080             


Gly Met  Ile Leu Lys Leu Lys  Leu Asn Thr Asp His  Gln Leu Glu 
    1085                 1090                 1095             


Val Glu  Ser Leu Glu Pro Lys  Lys Ile Tyr His Leu  Gly Ser Ser 
    1100                 1105                 1110             


Ala Lys  Asp Lys Pro Glu Tyr  Gln Tyr Cys Thr Asn  Gln Val Met 
    1115                 1120                 1125             


Met Ala  Tyr Cys Asn Met Cys  Arg Ser Leu Leu Glu  Met Lys Lys 
    1130                 1135                 1140             


<210>  1208
<211>  1186
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1208

Met Lys Val Thr Lys Ile Asp Gly Leu Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ile Glu Asp Ala Ser Gln Lys Asn Glu Thr 
            20                  25                  30          


Leu Glu Arg Leu Glu Lys Leu Lys Glu Ile Lys Leu Gly Asn Tyr Ile 
        35                  40                  45              


Lys Asn Pro Asp Lys Thr Lys Asp Lys Asp Asn Lys Lys Arg Arg Lys 
    50                  55                  60                  


Gly Leu Lys Glu Tyr Phe Ser Glu Ile Thr Leu Arg Lys Glu Asn Glu 
65                  70                  75                  80  


Lys Tyr Val Leu Leu Lys Gly Lys Lys Leu Lys Lys Ile Asn Asn Asp 
                85                  90                  95      


Ile Lys Asp Thr Asp Ile Lys Val Lys Tyr Lys Lys Glu Glu Val Phe 
            100                 105                 110         


Asp Val Leu Lys Lys Ile Leu Lys Leu Asn Leu Leu Ala Asn Asp Val 
        115                 120                 125             


Glu Glu Lys Ile Gln Phe Asp Ser Ile Lys Leu Lys Asn Val Phe Gly 
    130                 135                 140                 


Lys Asp Phe Val Lys Lys Glu Leu Gln Ile Lys Ser Ile Glu Glu Ser 
145                 150                 155                 160 


Leu Glu Lys Asn Lys Ala Asp Tyr Arg Lys Glu Phe Ile Glu Ile Glu 
                165                 170                 175     


Asn Asp Lys Tyr Gly Asn Val Lys Gly Glu Asn Lys Lys Asn Arg Ile 
            180                 185                 190         


Tyr Glu Tyr Tyr Lys Lys Ser Glu Thr His Glu Lys Phe Arg Lys Asn 
        195                 200                 205             


Ile Ile Glu Ala Phe Glu Lys Leu Tyr Lys Lys Asp Asp Ile Glu Lys 
    210                 215                 220                 


Leu Tyr Thr Gln Ile Ile Glu Ile Ser Lys Lys Met His Leu Lys Ser 
225                 230                 235                 240 


Lys Val Arg Glu Leu Tyr Lys Asn Val Ile Ile Lys Arg Ser Cys Asp 
                245                 250                 255     


Asp Phe Ser Lys Lys Asn Lys Glu Gly Ile Ser Val Leu Tyr Ser Gln 
            260                 265                 270         


Ile Met Asn Ser Val Lys Lys Asn Glu Lys Phe Val Lys Phe Val Lys 
        275                 280                 285             


Asn Ile Glu Leu Lys Asp Leu Thr Lys Ser Gln Ile Phe Tyr Lys Tyr 
    290                 295                 300                 


Phe Leu Glu Asn Glu Glu Leu Asn Asp Glu Asn Ile Lys Asn Ile Phe 
305                 310                 315                 320 


Cys Tyr Phe Val Glu Ile Glu Val Ser Asp Leu Leu Lys Gly Asn Val 
                325                 330                 335     


Tyr Lys Val Ser Lys Ile Tyr Glu Asn Lys Ile Lys Asn Ile Phe Glu 
            340                 345                 350         


Tyr Asn Lys Leu Lys Lys Leu Val Ile Asn Lys Leu Glu Asn Lys Leu 
        355                 360                 365             


Asn Asn Tyr Val Arg Asn Cys Gly Lys Tyr Asn Tyr His Met Glu Asn 
    370                 375                 380                 


Gly Asp Ile Ala Thr Ser Asp Ile Asn Met Arg Asn Arg Gln Thr Glu 
385                 390                 395                 400 


Ala Phe Leu Arg Ser Met Ile Gly Val Ser Ser Phe Gly Tyr Phe Ser 
                405                 410                 415     


Leu Arg Asn Ile Leu Gly Val Asn Asp Asp Asp Phe Tyr Glu Ile Glu 
            420                 425                 430         


Glu Asp Leu Thr Glu Glu Glu Arg Lys Asn Glu Ser Asn Val Leu Lys 
        435                 440                 445             


Lys Ala Lys Glu Asp Ile Thr Ser Lys Ser Ile Phe Glu Lys Val Val 
    450                 455                 460                 


Asp Lys Ser Phe Glu Lys Lys Gly Ile His Ser Ile Arg Glu Asn Val 
465                 470                 475                 480 


Lys Met Phe Tyr Gly Asp Ser Phe Asp Lys Ala Asn Glu Asp Glu Leu 
                485                 490                 495     


Lys Gln Phe Phe Val Asn Met Leu Asn Ala Ile Thr Ser Ile Arg His 
            500                 505                 510         


Arg Val Val His Tyr Asn Met Asn Thr Asn Ser Glu Asn Ile Phe Asn 
        515                 520                 525             


Phe Ser Asp Ile Glu Val Ser Arg Leu Leu Lys Ser Ile Phe Glu Lys 
    530                 535                 540                 


Glu Thr Asp Lys Arg Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn 
545                 550                 555                 560 


Ser Ala Gly Val Phe Asp Tyr Trp Glu Asn Trp Lys Ile Lys Lys Tyr 
                565                 570                 575     


Leu Glu Asn Met Lys Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val 
            580                 585                 590         


Pro Ser Phe Thr Lys Leu Tyr Asn Arg Ile Asp Asn Leu Lys Gly Ser 
        595                 600                 605             


Asn Ala Leu Asn Leu Gly Tyr Ile Asn Ile Pro Lys Arg Lys Glu Ala 
    610                 615                 620                 


Arg Asp Ser Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Lys Phe 
625                 630                 635                 640 


Val Glu Glu Phe Ile Lys Asn Asn Asp Asn Phe Glu Lys Ile Phe Arg 
                645                 650                 655     


Glu Ile Ile Glu Ile Asn Lys Asn Ala Gly Thr Asn Lys Gln Thr Asn 
            660                 665                 670         


Phe Tyr Lys Leu Glu Lys Phe Glu Lys Leu Lys Ala Asn Thr Pro Thr 
        675                 680                 685             


Glu Tyr Leu Glu Lys Leu Gln Ser Leu His Lys Ile Asn Tyr Asn Arg 
    690                 695                 700                 


Glu Lys Ile Glu Glu Asp Lys Asp Ile Tyr Val Asp Phe Val Gln Lys 
705                 710                 715                 720 


Ile Phe Leu Lys Gly Phe Ile Ser Tyr Leu Gln Lys Ser Asn Ser Leu 
                725                 730                 735     


Lys Pro Leu Asn Leu Leu Asn Leu Lys Lys Asp Glu Val Ile Asn Ser 
            740                 745                 750         


Glu Lys Ser Phe Tyr Asp Glu Lys Leu Lys Gln Trp Glu Asn Asn Gly 
        755                 760                 765             


Ser Asn Leu Ser Glu Met Pro Lys Glu Ile Tyr Lys Tyr Ile Lys Glu 
    770                 775                 780                 


Ile Lys Ile Asn Lys Thr Asn Tyr Ser Asp Arg Met Ser Ile Phe Tyr 
785                 790                 795                 800 


Leu Leu Leu Lys Leu Ile Asp His Lys Glu Leu Thr Asn Leu Arg Gly 
                805                 810                 815     


Asn Leu Glu Lys Tyr Glu Ser Met Asn Lys Asn Lys Ile Tyr Ser Glu 
            820                 825                 830         


Glu Leu Asn Ile Val Asn Leu Val Ser Leu Asp Asn Asn Lys Val Arg 
        835                 840                 845             


Thr Asn Phe Ser Val Glu Ala Glu Asp Ile Gly Lys Phe Leu Lys Thr 
    850                 855                 860                 


Glu Thr Ser Ile Lys Asn Ile Asn Gln Leu Asn Asn Phe Ser Gly Ile 
865                 870                 875                 880 


Phe Ala Asp Gly Glu Asn Val Ile Lys His Arg Ser Phe Tyr Asn Ile 
                885                 890                 895     


Lys Lys Tyr Gly Ile Leu Asp Leu Leu Glu Lys Ile Val Ala Lys Ala 
            900                 905                 910         


Asp Leu Lys Ile Ala Lys Glu Glu Ile Lys Lys Tyr Glu Asn Leu Gln 
        915                 920                 925             


Asn Glu Leu Lys Arg Asn Asp Phe Tyr Lys Ile Gln Glu Lys Ile His 
    930                 935                 940                 


Arg Lys Tyr Asn Gln Lys Pro Asn Leu Ile Leu Arg Thr Glu Asn Lys 
945                 950                 955                 960 


Lys Asp Phe Asn Asp Tyr Lys Lys Ala Ile Glu Asn Ile Gln Asn Tyr 
                965                 970                 975     


Thr Gln Leu Lys Asn Lys Ile Glu Phe Asn Asp Leu Asn Leu Leu Gln 
            980                 985                 990         


Gly Leu Leu Phe Arg Ile Leu His  Arg Leu Ala Gly Tyr  Thr Ser Leu 
        995                 1000                 1005             


Trp Glu  Arg Asp Leu Gln Phe  Lys Leu Lys Gly Glu  Phe Pro Glu 
    1010                 1015                 1020             


Asp Lys  Tyr Ile Asp Glu Ile  Phe Asn Ser Asp Arg  Asn Asn Asn 
    1025                 1030                 1035             


Gln Lys  Tyr Lys Ser Gly Gly  Ile Ala Tyr Lys Tyr  Val Asp Phe 
    1040                 1045                 1050             


Leu Ile  Glu Lys Glu Glu Gly  Lys Arg Ala Gly Lys  Asn Lys Val 
    1055                 1060                 1065             


Lys Lys  Arg Ser Glu Lys Glu  Gly Ser Phe Ile Ile  Arg Asn Tyr 
    1070                 1075                 1080             


Ile Ala  His Phe Asn Tyr Ile  Pro Asp Ala Glu Lys  Ser Ile Leu 
    1085                 1090                 1095             


Glu Ile  Leu Glu Glu Leu Arg  Glu Leu Leu Lys Tyr  Asp Arg Lys 
    1100                 1105                 1110             


Leu Lys  Asn Ala Val Met Lys  Ser Val Lys Asp Ile  Phe Lys Glu 
    1115                 1120                 1125             


Tyr Gly  Phe Ile Val Glu Phe  Arg Ile Ser His Glu  Ser Asn Ser 
    1130                 1135                 1140             


Lys Lys  Ile Lys Val Leu Asp  Val Lys Ser Glu Lys  Ile Lys His 
    1145                 1150                 1155             


Leu Lys  Asn Asn Gly Leu Val  Thr Thr Lys Asn Ser  Glu Asp Leu 
    1160                 1165                 1170             


Cys Glu  Leu Val Lys Val Met  Leu Glu Tyr Lys Lys  Ser 
    1175                 1180                 1185     


<210>  1209
<211>  1345
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1209

Met Lys Val Thr Lys Ala Glu Lys Leu Arg Val Ala Val Ser Arg Lys 
1               5                   10                  15      


Leu Asn Asn Glu Asp Lys Arg Ala Val Leu Tyr Lys Thr Pro Asn Pro 
            20                  25                  30          


Gly Gln Thr Cys Gly Thr Val Lys Lys Gln Leu Ala Asn Arg Val Glu 
        35                  40                  45              


Arg Ala Asn Lys Leu Tyr Gly Val Phe Phe Arg Ser Asp Val Pro Glu 
    50                  55                  60                  


Thr Leu Gln Tyr His Phe Glu Glu Leu Val Thr Tyr Ala Ala Gln Ser 
65                  70                  75                  80  


Thr Ser Pro Asn Glu Phe Arg Gln Lys Ala Ser Gln Tyr Arg Glu Cys 
                85                  90                  95      


Glu Lys Lys Asp Lys Phe Gly Lys Met Arg Lys Tyr Pro Ile Phe Arg 
            100                 105                 110         


Cys Ser Tyr Ala Pro Ser Gly Lys Asn Met Lys Lys Val Met Glu Leu 
        115                 120                 125             


Tyr Val Arg Glu Arg Met Lys Asp Glu Trp Gln Ser Gln Ala Tyr Arg 
    130                 135                 140                 


Thr Ala Ala Ile Glu Ile Leu Leu Cys Ile Cys Asn Lys Asp Phe Ser 
145                 150                 155                 160 


Lys Gln Leu Ser Arg Val Asp Ala Arg Ile Phe Ala Asp Phe Tyr Asn 
                165                 170                 175     


Ala Ser Lys Ala Cys Pro Gln Pro Tyr Ile Gly Lys Ser Thr Gly Val 
            180                 185                 190         


Leu Glu Ala Ala Phe Thr Ser Val Met Lys Gln Met Ser Leu His Ala 
        195                 200                 205             


Lys Ala Asn Ala Ser Asn Lys Ile Trp Trp Leu Gln Asn Gln Leu Arg 
    210                 215                 220                 


Thr Ile Glu Leu Asn Lys Lys Ile Val Lys Ile Ser Asp Phe Lys Tyr 
225                 230                 235                 240 


Glu Tyr Ala Thr Glu Asp Arg Met Arg Ala Ile Leu Val Arg Met Arg 
                245                 250                 255     


Lys Ser Leu Lys Arg Gly Thr Asn Gly Asp Ile Ala Val Ala Leu Leu 
            260                 265                 270         


Gln Gly Ile Ala Gln Met Asn Gly Lys Thr Leu Ser Gly Val Leu Glu 
        275                 280                 285             


Glu Leu Ser Ala Asn Ser Glu Thr Lys Glu Gln Leu Ile Lys Phe Leu 
    290                 295                 300                 


Lys Ala Val His Glu Asp Tyr His Lys Thr Pro Ile Leu Lys Ala Ile 
305                 310                 315                 320 


Arg Asn Gln Asp Val Lys Val Gln Val His Glu Val Asp Pro Val Ser 
                325                 330                 335     


Pro Glu Gly Arg Ala Leu Asp Leu Ala Ser Ile Asn Val Ser Lys Gly 
            340                 345                 350         


Asn Glu Arg Lys Lys Tyr Lys Val Ala Leu Thr Gln Thr Leu Gly Asn 
        355                 360                 365             


Tyr Ala Lys Ser Pro Lys Asp Ala Thr Gln Thr Leu Lys Ala Ile Lys 
    370                 375                 380                 


Gly Val Leu Leu Asp Tyr Phe Met Trp Leu Asp Ser Asp Val Lys Ala 
385                 390                 395                 400 


Glu Phe Leu Glu Asp Asn Asn Leu Trp Lys Ile Pro Asn Arg Thr Glu 
                405                 410                 415     


Glu Tyr Phe Asp Asn Asn Phe Val Pro Ile Asp Asp Lys Lys Asp Asp 
            420                 425                 430         


Lys Ile Glu Ala Ile Glu Asp Phe Ala Ser Ile Trp Arg Gln Glu Arg 
        435                 440                 445             


Val Lys Asn Ser Arg Ile Lys Ala Arg Met Asn Tyr Val Asn Cys Gly 
    450                 455                 460                 


Lys Tyr Gln Gln Leu Ile Lys Gln Glu Thr Asp Asp Phe Arg Ile Cys 
465                 470                 475                 480 


Trp Ile Ser Tyr Ala Lys Asp Phe Val Glu Lys Asn Tyr Val Ser Lys 
                485                 490                 495     


Asn Arg Gln Phe Thr Gln Gly Asp Cys Phe Ser Thr Lys Met Leu Leu 
            500                 505                 510         


Glu Cys Trp Lys Glu Ile Ile Arg Phe Ile Cys Gly Lys Tyr Ile Asp 
        515                 520                 525             


Ile Gly Lys Ala Val Tyr His Phe Ala Met Pro Glu Thr Met Asn Ala 
    530                 535                 540                 


Arg Asp Ser Leu Ala Tyr Gly Val Leu Gly Glu Lys Tyr Lys Glu Gly 
545                 550                 555                 560 


Ile Ser Ser Phe Asp Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln 
                565                 570                 575     


Arg Asp Ile Ala Lys Ala Ala Val Ala Ala Ile His Ala Phe Ser Gly 
            580                 585                 590         


Ser Val Ile Asp Asp Lys Lys Pro Val Glu Asp Ile Leu Phe Ile Lys 
        595                 600                 605             


Asp Glu Glu Leu Gln Glu His Ala Lys Ala Asp Asp Val Ile Val Lys 
    610                 615                 620                 


Gln Ile Leu Arg Phe Tyr Gly Gly Phe Ser Ser Val Glu Gly Arg Glu 
625                 630                 635                 640 


Lys Leu Glu Gly Met Ala Leu Ala Lys Glu Val Leu Ser Gln Leu Lys 
                645                 650                 655     


Ala Ile Arg Asn Glu Asn Phe His Phe Thr Gln Gly Lys Arg Lys Asn 
            660                 665                 670         


Val Glu Glu Asn Ile Pro Leu Thr Lys Ala Leu Trp Glu Asn Glu Glu 
        675                 680                 685             


Lys Val Tyr Arg Gln Thr Val Lys Glu Thr Tyr Tyr Ser Asn Asn Val 
    690                 695                 700                 


Ser Met Phe Tyr Ser Gln Glu Val Ile Gln Lys Leu Val Ala Glu Leu 
705                 710                 715                 720 


Tyr Gln Asn Asn Asn Val Ala Glu Ala Gln Ile Pro Ala Phe Arg Thr 
                725                 730                 735     


Ile Trp Lys Arg Lys Asp Leu Pro Glu Tyr Ile Gly Ser Leu Asn Ile 
            740                 745                 750         


Ser Trp Asp Lys Thr Glu Pro Lys Gln Val Ile Tyr Glu Gly Ala Leu 
        755                 760                 765             


Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Lys Ser Gly 
    770                 775                 780                 


Glu Ala Lys Lys Leu Phe Phe Asp Ala Val Met Asp Asn Ala Thr Glu 
785                 790                 795                 800 


Met Glu Lys Ser Ser Asn Ala Asp Ser Arg Asn Gln Glu Lys Lys Ala 
                805                 810                 815     


Leu Ala Asn Ala Gly Lys Asn Phe Arg Asp Tyr Val Asn Gly Leu Asn 
            820                 825                 830         


Ala Ser Thr Leu Gly Glu Val Cys Gln Phe Ile Gln Asn Glu Tyr Asn 
        835                 840                 845             


Gln Gln Asn Arg Gly Lys Gln Glu Gln Glu Ile Tyr Lys His Phe Lys 
    850                 855                 860                 


Met Leu Leu Pro Ile Cys Met Arg Lys Ala Phe Gln Arg Tyr Ile Asp 
865                 870                 875                 880 


Glu Lys His Ser Phe Ile Lys Lys Pro Gly Glu Leu Pro Gln Thr Thr 
                885                 890                 895     


Glu Asp Tyr Leu Glu Asn Val Lys Val Ala Cys Pro Glu Lys Lys Ile 
            900                 905                 910         


Lys Leu Gly Arg Trp Phe Thr Phe Ala His Phe Ile His Pro Arg Glu 
        915                 920                 925             


Leu Asn Phe Leu Ile Gly Asp Phe Lys Asn Tyr Ile Gln Tyr Arg Glu 
    930                 935                 940                 


Asp Val Leu Arg Arg Ser Glu His Ala Gly Gln Phe Ser Asp Thr Thr 
945                 950                 955                 960 


Glu Arg Asp Gly Glu Lys Ala Val Val Asp His Ala Val Gln Lys Ala 
                965                 970                 975     


Lys Asp Ile Leu Gly Val Leu Glu Phe Val Arg His Ile Ser Gly Arg 
            980                 985                 990         


Val Ser Asn Glu Phe Thr Asp Tyr  Tyr Ala Asp Arg Ala  Glu Tyr Asp 
        995                 1000                 1005             


Glu Tyr  Met Ala Lys Tyr Phe  Glu Pro Asp Val Gln  Ile Glu Gln 
    1010                 1015                 1020             


Tyr Asp  Leu Tyr Gly Asp Ala  Lys Asn Ala Lys Val  Ile Arg Asn 
    1025                 1030                 1035             


Ile Glu  Leu Ala Arg Met Tyr  Ala Gly Asp Ser Leu  Met Ser Ala 
    1040                 1045                 1050             


Ser Tyr  Arg Lys Ile Thr Lys  Lys Glu Ile Glu Thr  Tyr Tyr Ala 
    1055                 1060                 1065             


Lys Lys  Asp Glu Ile Ala Gln  Leu Gln Ser Gln Gly  Ile Cys Asn 
    1070                 1075                 1080             


Ser Lys  Lys Glu Gln Glu Asp  Ile Val Ala Phe Gln  Lys Leu Lys 
    1085                 1090                 1095             


Asn Arg  Ile Thr Leu Asn Glu  Val Thr Asp Leu Trp  Ser Leu Val 
    1100                 1105                 1110             


Asn Glu  Leu Leu Gly Asn Leu  Val Ser Leu Ala Tyr  Leu Arg Glu 
    1115                 1120                 1125             


Arg Asp  Glu Met Tyr Leu Phe  Leu Gly Phe Tyr Tyr  Met Ala Leu 
    1130                 1135                 1140             


Arg His  Pro Glu Gly Trp Thr  Asn Glu Ile Met Asn  Ser Val Ser 
    1145                 1150                 1155             


Asn Glu  Lys Tyr Ala Val Lys  Glu Gly Leu Val Leu  Tyr Gln Thr 
    1160                 1165                 1170             


Val Ala  Val Phe Asp Phe Gly  Thr Lys Leu Leu Phe  Gln Asn Asp 
    1175                 1180                 1185             


Asn Gln  Lys Trp Glu Glu Thr  Thr Gly Tyr Lys Trp  Gln His Phe 
    1190                 1195                 1200             


Ile Asp  Asn His Lys Glu Ser  Tyr Ala Cys Ile Leu  Pro Leu Phe 
    1205                 1210                 1215             


Glu Ile  Ala Lys Cys Glu Thr  Glu Ala Arg Ala Val  Arg Asn Tyr 
    1220                 1225                 1230             


Val Asp  His Phe Lys Tyr Tyr  Ser Asn Glu Asp Arg  Ser Ile Leu 
    1235                 1240                 1245             


Glu Leu  Tyr Gly Lys Phe Tyr  Thr His Leu Phe Gly  Tyr Ser Thr 
    1250                 1255                 1260             


Arg Leu  Arg Lys Ser Val Leu  Gln Ile Leu Ala Gln  Thr Leu Glu 
    1265                 1270                 1275             


Lys His  Gly Ile Ser Ala Gly  Ile Gln Phe Asp Gly  Thr Thr Val 
    1280                 1285                 1290             


Lys Ala  Thr Arg Cys Asp Met  Lys Ser Val Glu Phe  Thr Tyr Lys 
    1295                 1300                 1305             


Tyr Glu  Glu Lys Leu Asn Glu  Gln Lys Thr Val Leu  Arg Thr Ile 
    1310                 1315                 1320             


Ser Leu  Pro Ala Lys Ser Glu  Gly Phe Ile Thr Ala  Val Cys Glu 
    1325                 1330                 1335             


Met Leu  Lys Gln Lys Lys Gly  
    1340                 1345 


<210>  1210
<211>  1200
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1210

Met Asp Ala Asp Gly Leu Ser Ile Gly Pro Phe Ala Glu Ser His Asp 
1               5                   10                  15      


Ser Leu Val Ile Gly Gln Trp Ile Ser Thr Ile Asp Lys Ile Ala Thr 
            20                  25                  30          


Lys Pro Lys Gly Lys Gly Lys Ala Thr Gln Glu Gln Arg Asn Val Arg 
        35                  40                  45              


Ser Ala Leu Gly Ala Ala Cys Trp Ala Arg Leu Val His Pro Asp Gly 
    50                  55                  60                  


Thr Phe Gly Ala Leu Asp Ser Glu Arg Met Asn Trp Ala Arg Asn Thr 
65                  70                  75                  80  


Trp Glu Arg Arg Leu His Pro Tyr Ser Asp Lys Asn Phe Val Thr Asn 
                85                  90                  95      


Gly Arg Glu Lys Thr Pro Asp Ser Lys Ala His Trp Phe Asn Arg Phe 
            100                 105                 110         


Cys Lys Gly Leu Ser Val Gln Glu Val Thr Asp Pro Ser Val Ala Gly 
        115                 120                 125             


Asp Val Ala Gln Ser Ile Glu Glu His Leu Thr Lys Asp Ala Phe Arg 
    130                 135                 140                 


Arg Gly Gly Gly Thr Arg Arg Ser Pro Lys Ala Ser Ala Ser Arg Ala 
145                 150                 155                 160 


Gly Leu Ile Ala Val Arg Ala Asp Ser Ile Thr Lys Asn Ala Leu Arg 
                165                 170                 175     


Phe Pro Gly Ala Asp Ile Ala Glu Gln Arg Glu His Gly Trp Thr Glu 
            180                 185                 190         


Glu Asp Ile Ala Arg Tyr Val Ala Lys Ser Asp Pro Val Ala Gln Ile 
        195                 200                 205             


Tyr Lys Ala Val Leu Asp Ala Glu Pro Asp Gly Gln Arg Val Arg Trp 
    210                 215                 220                 


Ser Ile Ala Ala Glu Arg Leu Tyr Ala His Tyr Ala Arg Val Phe Thr 
225                 230                 235                 240 


Ala Pro Asp Ile Val Leu Asp Arg Lys Asp Ala Asp Lys Ile Leu Arg 
                245                 250                 255     


Gly Val Leu Ala Leu His Glu Ala Leu Arg Gln Leu Tyr Arg His Arg 
            260                 265                 270         


Leu Lys Arg His Arg Arg Lys Pro Val His Val Thr Val Leu Leu Pro 
        275                 280                 285             


Arg Asp Ile Arg Asp Ala Leu Thr Met Ile Ser Arg Gln Gln Asp Asn 
    290                 295                 300                 


Ser Asp Leu Asn Ala Leu Val Arg Leu Gly Lys Val Ile His His Glu 
305                 310                 315                 320 


Ala Ala Asp Gln Ala Gly Val Glu Ser Val Ala Lys Ile Ile Gly Asn 
                325                 330                 335     


Trp Pro Glu Asp Val Ser Arg Ser Tyr Tyr Trp Thr Ser Asp Gly Gln 
            340                 345                 350         


Thr Glu Ile Lys Arg Thr Glu Ala Phe Val Arg Ala Trp Arg Gly Pro 
        355                 360                 365             


Ile Ala His Ala Gln Arg Thr Leu Ala Asp Trp Val Asp Pro Asp Arg 
    370                 375                 380                 


Leu Ser Val Lys Ser Asp Ser Ala Glu Ala Lys Pro Pro Asp Met Leu 
385                 390                 395                 400 


Gly Ala Lys Phe Asp Asp Ala Leu Ala Gln Leu Asp Asp Asp Ala Ala 
                405                 410                 415     


Ile Thr Lys Ala Arg Leu Leu Phe Gly Thr Arg Ser Asp Ala Leu Gly 
            420                 425                 430         


Gly Pro Asp Pro Lys Ala Val Leu Arg Leu Thr Lys Arg Ala Leu Ser 
        435                 440                 445             


Lys Leu Arg Asn Ala Ala Phe His Phe Lys Gly Met Gly Gly Phe Val 
    450                 455                 460                 


Gln Asp Met Thr Leu Lys Ile Leu Pro Ser Gly Ser Glu Asp Cys Glu 
465                 470                 475                 480 


Val Leu Glu Arg Val His Ala Leu Trp His Ala Asp Gln Lys Asp Arg 
                485                 490                 495     


Met Ile Arg Val Lys Asp Ala Leu Val Gly Ala His Ala Glu Val Tyr 
            500                 505                 510         


Leu Asn Gln Pro Gln Met Asn Gln Leu Trp Glu Leu Leu Gly Ala Gln 
        515                 520                 525             


Glu Ser Lys Ile Ala Leu Pro Arg Phe Asn Arg Val Ile Ala Arg Ala 
    530                 535                 540                 


Ala His Ala Trp Thr Ser Lys Glu Asp Arg Leu Ala Leu Pro Asp Ser 
545                 550                 555                 560 


Ala Ser Ser Lys Asp Leu Glu Ala Gln Pro Ala Arg Arg Cys Gln Tyr 
                565                 570                 575     


Val Leu Ile Lys Met Val Tyr Glu Arg Gly Phe Arg Thr Trp Leu Thr 
            580                 585                 590         


Ser Arg Ser Ala Asp Asp Leu Asn Ile Trp Ile Lys Gln Ala Thr Asp 
        595                 600                 605             


His Thr Thr Glu Ala Ala Lys Glu Phe His Lys His Gln Val Ser Lys 
    610                 615                 620                 


Glu Glu Leu Ala Gln Ile Ser Ala Arg Ser Ala Gly Leu Val Lys Leu 
625                 630                 635                 640 


Glu Pro Gly Glu Gly Phe Ala Lys Phe Leu Phe Lys Met Thr Ala Leu 
                645                 650                 655     


Thr Thr Thr Glu Phe Arg Val Gln Lys Gly Tyr Thr His Asp Ala Gly 
            660                 665                 670         


Arg Ala Arg Glu Gln Ala Ser Phe Leu Asp Asp Leu His Cys Asp Leu 
        675                 680                 685             


Val Ala Leu Ala Phe Asp Thr Tyr Leu Lys Asp Lys Lys Leu Gly Trp 
    690                 695                 700                 


Leu Tyr Arg Leu Arg Gln Asp Glu Ser Pro Gly Asn Pro Gln Ser Ser 
705                 710                 715                 720 


Ala Ala Asp Leu Pro Leu Gly Ser Val Ala Ser Ala Gln Asp Trp Gln 
                725                 730                 735     


Ala Val Leu Tyr Leu Val Leu His Leu Ile Pro Val Asp Asp Val Gly 
            740                 745                 750         


Arg Leu Leu His Arg Trp Arg Trp Trp Ser Asn Lys Tyr Asp Asp Glu 
        755                 760                 765             


His Leu Pro Ala Glu Gly Leu Gln Leu Ala Glu Ala Phe Thr Leu Tyr 
    770                 775                 780                 


Leu Asp Met His Asp Ala Lys Phe Asp Gly Ala Glu Ala Ile Thr Gly 
785                 790                 795                 800 


Ser Ala Ala Phe His Asp Leu Phe Asp Ser Asp Thr Thr Arg Lys Gln 
                805                 810                 815     


Val Phe Pro Asp Ala Leu Ala Ala Glu Ala Glu Gly Pro Arg Gln Ile 
            820                 825                 830         


Met Gln Arg Gly Leu Arg Glu Met Leu Arg Phe Gly Asp Met Ala Ser 
        835                 840                 845             


Phe Ala Pro Val Phe Ala Gly Arg Lys Val Thr Ala Glu Gln Val Lys 
    850                 855                 860                 


Glu Trp Gln Asn Leu Asp Ala Gln Val Ala Ala Ala His Glu Thr Arg 
865                 870                 875                 880 


Lys Lys Val His Glu Asp Tyr Lys Arg Gly Leu Arg Pro Ser Thr Glu 
                885                 890                 895     


Asn Glu Arg Leu Leu Glu Gln Lys Tyr Asp Leu Ala Ala Tyr Val Lys 
            900                 905                 910         


Ala Val Lys Thr Ile Thr Arg His Lys Arg Leu Ser His His Val Lys 
        915                 920                 925             


Leu Thr Asn His Val Arg Leu His Gln Ile Val Met Arg Val Leu Gly 
    930                 935                 940                 


Arg Leu Val Asp Tyr Ala Gly Leu Trp Glu Arg Asp Val Tyr Phe Val 
945                 950                 955                 960 


Leu Leu Ala Leu Ile Cys Leu Arg Gly Gln Thr Pro Arg Asp Val Phe 
                965                 970                 975     


Gln Asn Ala Tyr Gly Arg Lys Ala Leu Arg Gly Gly Gln Ile Arg Lys 
            980                 985                 990         


Ala Val Gln Asn Leu Glu Pro Glu  Tyr Lys Thr Ala Leu  Glu Arg His 
        995                 1000                 1005             


Phe Gly  Thr Gly Ala Phe Glu  Glu Gly Gly Val Val  Thr Ile Arg 
    1010                 1015                 1020             


Asn Asp  Leu Ala His Leu Asn  Met Met Gly Arg Ala  Ala Arg Ser 
    1025                 1030                 1035             


Asp Asp  Ala Arg Val Pro Leu  Asp Leu Thr Cys Gln  Ile Asp Arg 
    1040                 1045                 1050             


Thr Arg  Arg Leu Met Ser Tyr  Asp Arg Lys Leu Gln  Asn Ser Val 
    1055                 1060                 1065             


Ser Lys  Ser Val Thr Asp Leu  Met Glu Arg Glu Lys  Ile Arg Leu 
    1070                 1075                 1080             


Ser Phe  Arg Leu Asp Lys Gly  Lys Leu Thr Gln Ala  Thr Val Lys 
    1085                 1090                 1095             


Ala Asp  Leu Ile Lys His Phe  Lys Arg Lys Glu Leu  Thr Glu Asn 
    1100                 1105                 1110             


Leu His  Asp Pro Leu Phe His  Gly Met Val Ala Asp  Val Tyr Gly 
    1115                 1120                 1125             


Gly Thr  Val Gly Gln Leu Gln  Asn Asp Leu Thr Asp  Ala Gln Asp 
    1130                 1135                 1140             


Ile Ala  Ala Val Val Asn Gln  Thr Phe Ala Ala Val  Lys Ala Glu 
    1145                 1150                 1155             


Gln Asp  Ala Arg Arg Arg Pro  Arg Asn Asn Arg Ala  Gln Ser Gln 
    1160                 1165                 1170             


Asn Pro  Gly Gly Gly Thr Arg  Arg Asn Gly Gly Lys  Glu Lys Tyr 
    1175                 1180                 1185             


Gly Lys  His Pro Lys Gly Lys  Arg Thr Asp Arg His  
    1190                 1195                 1200 


<210>  1211
<211>  1315
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1211

Met Ala Glu Thr Leu Thr Phe Thr Asn Leu Tyr Asp Ile Leu Thr Leu 
1               5                   10                  15      


Ile Asp Ser Gly Leu Asn Leu His Ile Asn Leu Gly Val Ile Ile Met 
            20                  25                  30          


Lys Leu Thr Arg Arg Arg Ile Ser Gly Asn Ser Val Asp Gln Lys Ile 
        35                  40                  45              


Thr Ala Ala Phe Tyr Arg Asp Met Ser Gln Gly Leu Leu Tyr Tyr Asp 
    50                  55                  60                  


Ser Glu Asp Asn Asp Cys Thr Asp Lys Val Ile Glu Ser Met Asp Phe 
65                  70                  75                  80  


Glu Arg Ser Trp Arg Gly Arg Ile Leu Lys Asn Gly Glu Asp Asp Lys 
                85                  90                  95      


Asn Pro Phe Tyr Met Phe Val Lys Gly Leu Val Gly Ser Asn Asp Lys 
            100                 105                 110         


Ile Val Cys Glu Pro Ile Asp Val Asp Ser Asp Pro Asp Asn Leu Asp 
        115                 120                 125             


Ile Leu Ile Asn Lys Asn Leu Thr Gly Phe Gly Arg Asn Leu Lys Ala 
    130                 135                 140                 


Pro Asp Ser Asn Asp Thr Leu Glu Asn Leu Ile Arg Lys Ile Gln Ala 
145                 150                 155                 160 


Gly Ile Pro Glu Glu Glu Val Leu Pro Glu Leu Lys Lys Ile Lys Glu 
                165                 170                 175     


Met Ile Gln Lys Asp Ile Val Asn Arg Lys Glu Gln Leu Leu Lys Ser 
            180                 185                 190         


Ile Lys Asn Asn Arg Ile Pro Phe Ser Leu Glu Gly Ser Lys Leu Val 
        195                 200                 205             


Pro Ser Thr Lys Lys Met Lys Trp Leu Phe Lys Leu Ile Asp Val Pro 
    210                 215                 220                 


Asn Lys Thr Phe Asn Glu Lys Met Leu Glu Lys Tyr Trp Glu Ile Tyr 
225                 230                 235                 240 


Asp Tyr Asp Lys Leu Glu Ala Asn Ile Thr Asn Arg Leu Asp Lys Thr 
                245                 250                 255     


Asp Lys Asn Ala Arg Ser Ile Ser Arg Ala Val Ser Asp Glu Leu Arg 
            260                 265                 270         


Glu Tyr His Lys Tyr Leu Arg Thr Asn Tyr Asn Arg Phe Val Ser Gly 
        275                 280                 285             


Asp Arg Pro Ala Ala Gly Leu Asp Asn Gly Gly Ser Ala Lys Tyr Asn 
    290                 295                 300                 


Pro Asp Lys Glu Glu Phe Leu Leu Phe Leu Lys Glu Val Glu Gln Tyr 
305                 310                 315                 320 


Phe Lys Lys Tyr Phe Pro Val Lys Ser Lys His Ser Asn Lys Ser Lys 
                325                 330                 335     


Asp Lys Ser Leu Val Asp Lys Tyr Lys Asn Tyr Cys Ser Tyr Lys Val 
            340                 345                 350         


Val Lys Lys Glu Val Asn Arg Ser Ile Ile Asn Gln Leu Val Ala Gly 
        355                 360                 365             


Leu Ile Gln Gln Gly Lys Leu Leu Tyr Tyr Phe Tyr Tyr Asn Asp Thr 
    370                 375                 380                 


Trp Gln Glu Asp Phe Leu Asn Ser Tyr Gly Leu Ser Tyr Ile Gln Val 
385                 390                 395                 400 


Glu Glu Ala Phe Lys Lys Ser Val Met Thr Ser Leu Ser Trp Gly Ile 
                405                 410                 415     


Asn Arg Leu Thr Ser Phe Phe Ile Asp Asp Ser Asn Thr Val Lys Phe 
            420                 425                 430         


Asp Asp Ile Thr Thr Lys Arg Ala Lys Glu Ala Ile Glu Ser Asn Tyr 
        435                 440                 445             


Phe Asn Lys Leu Arg Thr Cys Ser Arg Met Gln Asp His Phe Lys Glu 
    450                 455                 460                 


Lys Leu Ala Phe Phe Tyr Pro Val Tyr Val Lys Asp Lys Lys Asp Arg 
465                 470                 475                 480 


Pro Asp Asp Ile Glu Lys Leu Ile Val Leu Val Lys Asn Ala Ile Glu 
                485                 490                 495     


Ser Val Ser Tyr Leu Arg Asn Arg Ile Phe His Phe Lys Lys Ser Ser 
            500                 505                 510         


Leu Leu Glu Leu Leu Lys Glu Leu Asp Asp Lys Asn Ser Gly Gln Asp 
        515                 520                 525             


Lys Ile Asp Tyr Ser Val Ala Ala Glu Phe Ile Lys Arg Asp Ile Glu 
    530                 535                 540                 


Asn Leu Tyr Asp Val Phe Arg Glu Gln Ile Arg Ser Leu Gly Ile Ala 
545                 550                 555                 560 


Glu Tyr Tyr Lys Ala Asp Met Ile Ser Asp Cys Phe Lys Thr Cys Gly 
                565                 570                 575     


Leu Glu Phe Ala Leu Tyr Ser Pro Lys Asn Ser Leu Met Pro Ala Phe 
            580                 585                 590         


Lys Asn Val Tyr Lys Arg Gly Ala Asn Leu Asn Lys Ala Tyr Ile Arg 
        595                 600                 605             


Asp Lys Gly Pro Lys Glu Thr Gly Asp Gln Gly Gln Asn Ser Tyr Lys 
    610                 615                 620                 


Ala Leu Glu Glu Tyr Arg Glu Leu Thr Trp Tyr Ile Glu Val Lys Asn 
625                 630                 635                 640 


Asn Asp Gln Ser Tyr Asn Ala Tyr Lys Asn Leu Leu Gln Leu Ile Tyr 
                645                 650                 655     


Tyr His Ala Phe Leu Pro Glu Val Arg Glu Asn Glu Ala Leu Ile Thr 
            660                 665                 670         


Asp Phe Ile Asn Arg Thr Lys Glu Trp Asn Arg Lys Glu Thr Glu Glu 
        675                 680                 685             


Arg Leu Asn Thr Lys Asn Asn Lys Lys His Lys Asn Phe Asp Glu Asn 
    690                 695                 700                 


Asp Asp Ile Thr Val Asn Thr Tyr Arg Tyr Glu Ser Ile Pro Asp Tyr 
705                 710                 715                 720 


Gln Gly Glu Ser Leu Asp Asp Tyr Leu Lys Val Leu Gln Arg Lys Gln 
                725                 730                 735     


Met Ala Arg Ala Lys Glu Val Asn Glu Lys Glu Glu Gly Asn Asn Asn 
            740                 745                 750         


Tyr Ile Gln Phe Ile Arg Asp Val Val Val Trp Ala Phe Gly Ala Tyr 
        755                 760                 765             


Leu Glu Asn Lys Leu Lys Asn Tyr Lys Asn Glu Leu Gln Pro Pro Leu 
    770                 775                 780                 


Ser Lys Glu Asn Ile Gly Leu Asn Asp Thr Leu Lys Glu Leu Phe Pro 
785                 790                 795                 800 


Glu Glu Lys Val Lys Ser Pro Phe Asn Ile Lys Cys Arg Phe Ser Ile 
                805                 810                 815     


Ser Thr Phe Ile Asp Asn Lys Gly Lys Ser Thr Asp Asn Thr Ser Ala 
            820                 825                 830         


Glu Ala Val Lys Thr Asp Gly Lys Glu Asp Glu Lys Asp Lys Lys Asn 
        835                 840                 845             


Ile Lys Arg Lys Asp Leu Leu Cys Phe Tyr Leu Phe Leu Arg Leu Leu 
    850                 855                 860                 


Asp Glu Asn Glu Ile Cys Lys Leu Gln His Gln Phe Ile Lys Tyr Arg 
865                 870                 875                 880 


Cys Ser Leu Lys Glu Arg Arg Phe Pro Gly Asn Arg Thr Glu Leu Glu 
                885                 890                 895     


Lys Glu Thr Glu Leu Leu Ala Glu Leu Glu Glu Leu Met Glu Leu Val 
            900                 905                 910         


Arg Phe Thr Met Pro Ser Ile Pro Glu Ile Ser Ala Lys Ala Glu Ser 
        915                 920                 925             


Gly Tyr Asp Thr Met Ile Lys Lys Tyr Phe Lys Asp Phe Ile Glu Lys 
    930                 935                 940                 


Lys Val Phe Lys Asn Pro Lys Thr Ser Asn Leu Tyr Tyr His Ser Asp 
945                 950                 955                 960 


Ser Lys Thr Pro Val Thr Arg Lys Tyr Met Ala Leu Leu Met Arg Ser 
                965                 970                 975     


Ala Pro Leu His Leu Tyr Lys Asp Ile Phe Lys Gly Tyr Tyr Leu Ile 
            980                 985                 990         


Thr Lys Lys Glu Cys Leu Glu Tyr  Ile Lys Leu Ser Asn  Ile Ile Lys 
        995                 1000                 1005             


Asp Tyr  Gln Asn Ser Leu Asn  Glu Leu His Glu Gln  Leu Glu Arg 
    1010                 1015                 1020             


Ile Lys  Leu Lys Ser Glu Lys  Gln Asn Gly Lys Asp  Ser Leu Tyr 
    1025                 1030                 1035             


Leu Asp  Lys Lys Asp Phe Tyr  Lys Val Lys Glu Tyr  Val Glu Asn 
    1040                 1045                 1050             


Leu Glu  Gln Val Ala Arg Tyr  Lys His Leu Gln His  Lys Ile Asn 
    1055                 1060                 1065             


Phe Glu  Thr Leu Tyr Arg Ile  Phe Arg Ile His Val  Asp Ile Ala 
    1070                 1075                 1080             


Ala Arg  Met Val Gly Tyr Thr  Gln Asp Trp Glu Arg  Asp Met His 
    1085                 1090                 1095             


Phe Leu  Phe Lys Ala Leu Val  Tyr Asn Gly Val Leu  Glu Glu Arg 
    1100                 1105                 1110             


Arg Phe  Glu Ala Ile Phe Asn  Asn Asn Asp Asp Asn  Asn Asp Gly 
    1115                 1120                 1125             


Arg Ile  Val Lys Lys Ile Gln  Asn Asn Leu Asn Asn  Lys Asn Arg 
    1130                 1135                 1140             


Glu Leu  Val Ser Met Leu Cys  Trp Asn Lys Lys Leu  Asn Lys Asn 
    1145                 1150                 1155             


Glu Phe  Gly Ala Ile Ile Trp  Lys Arg Asn Pro Ile  Ala His Leu 
    1160                 1165                 1170             


Asn His  Phe Thr Gln Thr Glu  Gln Asn Ser Lys Ser  Ser Leu Glu 
    1175                 1180                 1185             


Ser Leu  Ile Asn Ser Leu Arg  Ile Leu Leu Ala Tyr  Asp Arg Lys 
    1190                 1195                 1200             


Arg Gln  Asn Ala Val Thr Lys  Thr Ile Asn Asp Leu  Leu Leu Asn 
    1205                 1210                 1215             


Asp Tyr  His Ile Arg Ile Lys  Trp Glu Gly Arg Val  Asp Glu Gly 
    1220                 1225                 1230             


Gln Ile  Tyr Phe Asn Ile Lys  Glu Lys Glu Asp Ile  Glu Asn Glu 
    1235                 1240                 1245             


Pro Ile  Ile His Leu Lys His  Leu His Lys Lys Asp  Cys Tyr Ile 
    1250                 1255                 1260             


Tyr Lys  Asn Ser Tyr Met Phe  Asp Lys Gln Lys Glu  Trp Ile Cys 
    1265                 1270                 1275             


Asn Gly  Ile Lys Glu Glu Val  Tyr Asp Lys Ser Ile  Leu Lys Cys 
    1280                 1285                 1290             


Ile Gly  Asn Leu Phe Lys Phe  Asp Tyr Glu Asp Lys  Asn Lys Ser 
    1295                 1300                 1305             


Ser Ala  Asn Pro Lys His Thr  
    1310                 1315 


<210>  1212
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1212

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  1213
<211>  1193
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1213

Met Lys Val Thr Lys Ile Asp Gly Ile Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Phe Thr Gly His Phe Asn Ile Lys Asn Glu 
            20                  25                  30          


Met Lys Glu Arg Leu Glu Lys Leu Lys Glu Leu Lys Leu Ser Asn Tyr 
        35                  40                  45              


Val Lys Asn Pro Glu Asn Val Lys Asn Lys Asp Lys Asn Lys Glu Lys 
    50                  55                  60                  


Glu Thr Lys Ser Arg Arg Glu Asn Leu Lys Lys Tyr Phe Ser Glu Ile 
65                  70                  75                  80  


Ile Leu Arg Lys Lys Glu Glu Lys Tyr Leu Leu Lys Lys Thr Arg Lys 
                85                  90                  95      


Phe Lys Asn Ile Thr Glu Glu Ile Asn Tyr Asp Asp Ile Lys Lys Gly 
            100                 105                 110         


Glu Asn Gln Gln Lys Ile Phe Asp Ile Leu Lys Glu Leu Leu Lys Gln 
        115                 120                 125             


Arg Ile Asn Glu Asn Asp Asn Glu Glu Ile Leu Asn Phe Asp Ser Val 
    130                 135                 140                 


Lys Leu Lys Glu Ala Phe Gly Glu Asp Phe Ile Lys Lys Glu Leu Lys 
145                 150                 155                 160 


Ile Lys Ala Ile Glu Glu Ser Leu Glu Lys Asn Arg Ala Asp Tyr Arg 
                165                 170                 175     


Lys Asp Phe Val Glu Leu Glu Asn Gly Lys Tyr Glu Asp Val Lys Gly 
            180                 185                 190         


Gln Asn Lys Arg Ser Ile Val Phe Glu Tyr Tyr Lys Asn Pro Glu Asn 
        195                 200                 205             


Gln Glu Lys Phe Lys Glu Asn Ile Lys Tyr Ala Phe Glu Asn Leu Tyr 
    210                 215                 220                 


Thr Glu Glu Asn Ile Lys Asn Leu Tyr Ser Glu Ile Lys Glu Ile Phe 
225                 230                 235                 240 


Glu Lys Val His Leu Lys Ser Lys Val Arg Tyr Phe Tyr Gln Asn Glu 
                245                 250                 255     


Ile Ile Gly Glu Ser Glu Phe Ser Glu Lys Asp Glu Glu Gly Ile Ser 
            260                 265                 270         


Ile Leu Tyr Lys Gln Ile Ile Asn Ser Val Glu Lys Lys Glu Lys Phe 
        275                 280                 285             


Ile Glu Phe Leu Gln Lys Val Lys Ile Lys Asp Leu Thr Lys Ser Gln 
    290                 295                 300                 


Ile Phe Tyr Lys Tyr Phe Val Glu Asn Glu Glu Leu Asn Asp Glu Asn 
305                 310                 315                 320 


Ile Lys Tyr Ile Phe Ser Tyr Phe Val Glu Ile Glu Val Asn Lys Leu 
                325                 330                 335     


Leu Lys Glu Asn Val Tyr Lys Ile Lys Arg Phe Asn Glu Gly Asn Lys 
            340                 345                 350         


Lys Arg Ile Glu Asn Ile Phe Glu Tyr Gly Lys Leu Lys Lys Leu Ile 
        355                 360                 365             


Val Tyr Lys Leu Glu Asn Lys Leu Asn Asn Tyr Val Arg Asn Cys Gly 
    370                 375                 380                 


Lys Tyr Asn Tyr His Met Glu Asn Gly Asp Ile Ala Thr Ser Asp Ile 
385                 390                 395                 400 


Asn Met Lys Asn Arg Gln Thr Glu Ala Phe Leu Arg Ser Ile Leu Gly 
                405                 410                 415     


Val Ser Ser Phe Gly Tyr Phe Ser Leu Arg Asn Ile Leu Gly Val Asn 
            420                 425                 430         


Asp Asp Asp Phe Tyr Lys Ile Glu Lys Glu Leu Thr Glu Asp Glu Arg 
        435                 440                 445             


Lys Lys Asn Phe Ile Leu Lys Lys Ala Lys Glu Asp Phe Thr Ser Lys 
    450                 455                 460                 


Asn Ile Phe Lys Lys Val Ile Asp Lys Ser Phe Glu Lys Lys Gly Ile 
465                 470                 475                 480 


Tyr Gln Ile Lys Glu Asn Leu Lys Met Phe Tyr Gly Asp Ser Phe Asp 
                485                 490                 495     


Asn Ala Asp Lys Asp Glu Leu Lys Lys Phe Phe Val Asn Met Leu Glu 
            500                 505                 510         


Ala Ile Thr Ser Ile Arg His Arg Ile Val His Tyr Asn Ile Asn Thr 
        515                 520                 525             


Asn Ser Glu Asn Ile Phe Asn Phe Ser Asp Thr Glu Val Ser Arg Leu 
    530                 535                 540                 


Leu Lys Ser Ile Phe Glu Lys Glu Thr Asp Lys Arg Glu Leu Lys Leu 
545                 550                 555                 560 


Lys Ile Phe Arg Gln Leu Asn Ser Ala Gly Val Phe Asp Tyr Trp Glu 
                565                 570                 575     


Asn Trp Lys Ile Lys Lys Tyr Leu Glu Asn Ile Lys Phe Glu Phe Val 
            580                 585                 590         


Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys Leu Tyr Asn Arg 
        595                 600                 605             


Ile Asp Asp Leu Lys Ala Gly Asn Ala Leu Lys Leu Gly Asn His Ile 
    610                 615                 620                 


Ile Ile Pro Lys Arg Lys Glu Ala Arg Asp Ser Gln Ile Tyr Leu Leu 
625                 630                 635                 640 


Lys Asn Ile Tyr Tyr Gly Glu Phe Val Glu Lys Phe Val Asn Asn Asn 
                645                 650                 655     


Asp Asn Phe Glu Lys Ile Phe Arg Glu Ile Ile Lys Ile Asn Lys Asn 
            660                 665                 670         


Ala Gly Thr Asn Thr Glu Thr Lys Phe Tyr Lys Leu Glu Lys Phe Glu 
        675                 680                 685             


Thr Leu Lys Ala Asn Thr Pro Thr Glu Tyr Leu Glu Lys Leu Gln Ser 
    690                 695                 700                 


Leu His Lys Ile Ser Tyr Asp Lys Glu Lys Ile Glu Glu Asp Lys Asp 
705                 710                 715                 720 


Val Tyr Val Asp Phe Val Gln Lys Ile Phe Leu Lys Gly Phe Val Asn 
                725                 730                 735     


Tyr Leu Lys Lys Leu Asp Ser Leu Lys Ser Leu Asn Leu Leu Asn Leu 
            740                 745                 750         


Arg Lys Asp Glu Val Ile Thr Asp Lys Lys Ser Phe Tyr Asp Glu Lys 
        755                 760                 765             


Leu Lys Leu Trp Glu Asn Ser Gly Ser Asn Leu Ser Lys Ile Pro Glu 
    770                 775                 780                 


Glu Ile Tyr Glu Tyr Val Lys Lys Ile Lys Ile Ser Asn Ile Asn Tyr 
785                 790                 795                 800 


Asn Asp Arg Met Ser Ile Phe Tyr Leu Leu Leu Lys Leu Ile Asp Tyr 
                805                 810                 815     


Arg Glu Leu Thr Asn Leu Arg Gly Asn Leu Glu Lys Tyr Glu Ser Met 
            820                 825                 830         


Asn Lys Asn Lys Ile Tyr Ser Glu Glu Leu Thr Ile Ile Asn Leu Val 
        835                 840                 845             


Asn Leu Asp Asn Asn Lys Val Arg Thr Asn Phe Ser Leu Glu Ala Glu 
    850                 855                 860                 


Asp Ile Gly Lys Phe Leu Lys Ser Ser Ile Thr Ile Lys Asn Ile Ala 
865                 870                 875                 880 


Gln Leu Asn Asn Phe Ser Glu Ile Phe Ala Asp Gly Glu Asn Val Ile 
                885                 890                 895     


Lys His Arg Ser Phe Tyr Asn Ile Lys Lys Tyr Gly Ile Leu Asp Leu 
            900                 905                 910         


Leu Glu Lys Ile Val Asp Lys Ala Asp Leu Lys Ile Thr Lys Glu Glu 
        915                 920                 925             


Ile Lys Lys Tyr Glu Asn Leu Gln Asn Glu Leu Lys Arg Asn Asp Phe 
    930                 935                 940                 


Tyr Lys Ile Gln Glu Arg Ile His Lys Asn Tyr Asn Gln Lys Pro Phe 
945                 950                 955                 960 


Leu Ile Lys Asn Asn Glu Lys Asp Phe Asn Asp Tyr Lys Lys Ala Ile 
                965                 970                 975     


Glu Asn Ile Gln Asn Tyr Thr Gln Leu Lys Asn Lys Ile Glu Phe Asn 
            980                 985                 990         


Asp Leu Asn Leu Leu Gln Ser Leu  Leu Phe Arg Ile Leu  His Arg Leu 
        995                 1000                 1005             


Ala Gly  Tyr Thr Ser Leu Trp  Glu Arg Asp Leu Gln  Phe Lys Leu 
    1010                 1015                 1020             


Lys Gly  Glu Tyr Pro Glu Asp  Lys Tyr Ile Asp Glu  Ile Phe Asn 
    1025                 1030                 1035             


Phe Asp  Asn Ser Lys Asn Glu  Lys Tyr Lys Asn Gly  Ala Ile Val 
    1040                 1045                 1050             


Phe Lys  Tyr Val Asp Phe Leu  Ile Glu Lys Lys Glu  Gly Lys Arg 
    1055                 1060                 1065             


Ala Gly  Thr Lys Lys Ile Asn  Lys Lys Ser Glu Glu  Lys Gly Leu 
    1070                 1075                 1080             


Glu Ile  Arg Asn Tyr Ile Ala  His Phe Asn Tyr Ile  Pro Asp Ala 
    1085                 1090                 1095             


Thr Lys  Ser Ile Leu Glu Ile  Leu Glu Glu Leu Arg  Asn Leu Leu 
    1100                 1105                 1110             


Lys Tyr  Asp Arg Lys Leu Lys  Asn Ala Val Met Lys  Ser Ile Lys 
    1115                 1120                 1125             


Asp Ile  Phe Lys Glu Tyr Gly  Phe Ile Val Glu Phe  Thr Ile Ser 
    1130                 1135                 1140             


His Thr  Lys Asn Gly Lys Lys  Ile Lys Val Cys Ser  Val Lys Ser 
    1145                 1150                 1155             


Glu Lys  Ile Lys His Leu Lys  Asn Asn Glu Leu Ile  Thr Thr Arg 
    1160                 1165                 1170             


Asn Ser  Glu Asp Leu Cys Asp  Leu Val Lys Ile Met  Leu Glu Tyr 
    1175                 1180                 1185             


Lys Lys  Leu Gln Lys 
    1190             


<210>  1214
<211>  1162
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1214

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Glu 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Gly Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Lys Asp Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Arg Ile Asp Ser 
                405                 410                 415     


Lys Thr Gly Glu Glu Lys Tyr Ile Pro Gly Glu Val Asp Gln Ile Tyr 
            420                 425                 430         


Tyr Glu Asn Lys Gln Asn Glu Val Lys Asn Lys Leu Lys Met Phe Tyr 
        435                 440                 445             


Gly Tyr Asp Phe Asp Met Asp Asn Lys Lys Glu Ile Glu Asp Phe Phe 
    450                 455                 460                 


Ala Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His 
465                 470                 475                 480 


Phe Asn Leu Asp Leu Asp Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile 
                485                 490                 495     


Val Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu 
            500                 505                 510         


Lys Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val 
        515                 520                 525             


Phe Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr 
    530                 535                 540                 


Arg Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr 
545                 550                 555                 560 


Lys Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr 
                565                 570                 575     


Trp Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile 
            580                 585                 590         


Asp Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu 
        595                 600                 605             


Asn Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Lys Glu 
    610                 615                 620                 


Ile Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe 
625                 630                 635                 640 


Tyr Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu 
                645                 650                 655     


Tyr Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln 
            660                 665                 670         


Asp Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe 
        675                 680                 685             


Leu Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu 
    690                 695                 700                 


Ile Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys 
705                 710                 715                 720 


Lys Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn 
                725                 730                 735     


Ile Lys Ile Pro Tyr Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu 
            740                 745                 750         


Gly Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile 
        755                 760                 765             


Leu Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu 
    770                 775                 780                 


Glu Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu 
785                 790                 795                 800 


Glu Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp 
                805                 810                 815     


Phe Glu Leu Glu Ala Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly 
            820                 825                 830         


Asn Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys 
        835                 840                 845             


Ile Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn 
    850                 855                 860                 


Ile Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys 
865                 870                 875                 880 


Ala Gly Tyr Lys Ile Ser Ile Glu Glu Leu Lys Lys Tyr Ser Asn Lys 
                885                 890                 895     


Lys Asn Glu Ile Glu Lys Asn His Lys Met Gln Glu Asn Leu His Arg 
            900                 905                 910         


Lys Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr 
        915                 920                 925             


Glu Ser Tyr Lys Gln Ala Ile Lys Asn Ile Glu Glu Tyr Thr His Leu 
    930                 935                 940                 


Lys Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu 
945                 950                 955                 960 


Leu Arg Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg 
                965                 970                 975     


Asp Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile 
            980                 985                 990         


Glu Glu Ile Phe Asn Phe Glu Asn  Lys Lys Asn Val Lys  Tyr Lys Ser 
        995                 1000                 1005             


Gly Gln  Ile Val Glu Lys Tyr  Ile Lys Phe Tyr Lys  Glu Leu His 
    1010                 1015                 1020             


Gln Asn  Asp Glu Val Lys Ile  Asn Lys Tyr Ser Ser  Ala Asn Ile 
    1025                 1030                 1035             


Lys Val  Leu Lys Gln Glu Lys  Lys Asp Leu Tyr Ile  Arg Asn Tyr 
    1040                 1045                 1050             


Ile Ala  His Phe Asn Tyr Ile  Pro His Ala Glu Ile  Ser Leu Leu 
    1055                 1060                 1065             


Glu Val  Leu Glu Asn Leu Arg  Lys Leu Leu Ser Tyr  Asp Arg Lys 
    1070                 1075                 1080             


Leu Lys  Asn Ala Val Met Lys  Ser Val Val Asp Ile  Leu Lys Glu 
    1085                 1090                 1095             


Tyr Gly  Phe Val Val Lys Phe  Lys Ile Gly Ala Asp  Lys Lys Ile 
    1100                 1105                 1110             


Gly Ile  Gln Thr Leu Glu Ser  Glu Lys Ile Val His  Leu Lys Asn 
    1115                 1120                 1125             


Leu Lys  Lys Lys Lys Leu Met  Thr Asp Arg Asn Ser  Glu Glu Leu 
    1130                 1135                 1140             


Cys Lys  Leu Val Lys Val Met  Phe Glu Tyr Lys Met  Glu Glu Lys 
    1145                 1150                 1155             


Lys Ser  Glu Asn 
    1160         


<210>  1215
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1215

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  1216
<211>  1243
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (6)..(64)
<223>  Xaa can be any naturally occurring amino acid

<400>  1216

Met Leu Gln Lys Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
1               5                   10                  15      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        35                  40                  45              


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Asp Ser Lys Lys Gln Asn Lys Gly Asp Ala Ser Ser Ala Ala Glu Asn 
65                  70                  75                  80  


Ser Glu Asn Gln Thr Thr Arg Thr Pro Lys Ala Ser Lys Asp Trp Ile 
                85                  90                  95      


Arg Ile Val Gln Gln Met Tyr Arg Lys Glu Asn Ile Arg Arg Tyr Arg 
            100                 105                 110         


Leu Ser Ile Lys Thr Ile Lys Ala Tyr Ser Asn Glu Ala Ser Ser Asp 
        115                 120                 125             


Thr Ile Thr Asp Asp Glu Val Thr Thr Val Lys Asp Leu Thr Ser Ser 
    130                 135                 140                 


Thr Glu Leu Ser Ile Val Glu Lys Thr Pro Tyr Phe Gln Asp Glu Ser 
145                 150                 155                 160 


Ile Asn Met Phe Trp Ile Arg Tyr Ile Glu Lys Ser Val Glu Arg Ile 
                165                 170                 175     


Tyr Asn Asn Phe Arg Ser Leu Asp Asp Tyr Arg Leu Ser Val Gly Tyr 
            180                 185                 190         


Leu Ser Glu Lys Val Trp Lys Gly Ile Phe Ser Phe Leu Ser Gly Lys 
        195                 200                 205             


Tyr Ile Ala Thr Gly Lys Ala Val Tyr His Phe Ala Phe Gln Glu Leu 
    210                 215                 220                 


Ser Pro Gln Lys Glu Glu Ala Asp Thr Ser Gln Ile Val Glu Asn Thr 
225                 230                 235                 240 


Gln Thr Gln Glu Thr Gln Asn Ser Gln Asn Ser Gln Val Ala Arg Asn 
                245                 250                 255     


Lys Gly Lys Asn Lys Gly Arg Lys Lys Gln His Gln Lys Ala Val Ser 
            260                 265                 270         


Lys Arg Ala Met Ile Gly Ala Ala Glu Gln Ala Arg Asn Asn Thr Ala 
        275                 280                 285             


Asn Ile Val Lys Asn Thr Ile Ala Asn Ser Thr Asp Thr Ile Asp Ser 
    290                 295                 300                 


Lys Pro Arg Leu Glu Asp Ser Thr Val Ser Leu Asp Leu Gly Lys Ile 
305                 310                 315                 320 


Arg Glu Asn Leu Lys Ser Gly Leu Asn Ser Phe Asp Tyr Glu Met Leu 
                325                 330                 335     


Lys Ala Glu Glu Asp Leu Gln Arg Ser Thr Ala Val Tyr Val Ala Phe 
            340                 345                 350         


Ala Ala Asn His Leu Ser Ala Ala Thr Val Asp Leu Ala Leu Leu Glu 
        355                 360                 365             


Gly Glu Glu Gly Lys Glu Asp Phe Leu Thr Leu Lys Arg Lys Asp Leu 
    370                 375                 380                 


Ala Arg Val Val Lys Thr Pro Leu Arg Arg Asn Ile Leu Gln Phe Phe 
385                 390                 395                 400 


Gly Gly Glu Ser Met Trp Gly Asp Phe Cys Phe Glu Asp Tyr Tyr Arg 
                405                 410                 415     


Lys Pro Asn Lys Asn Gln Tyr Asp Asp Leu Asp Phe Leu Asp Asp Leu 
            420                 425                 430         


Lys Thr Ile Ile Phe Ala Met Arg Asn Glu Ser Phe His Phe Glu Thr 
        435                 440                 445             


Arg Arg Glu Asn Lys Gly Thr Trp Asn Gln Asn Leu Ile Thr Ala Met 
    450                 455                 460                 


Phe Glu His Asp Cys Ala Ala Ala Ser Lys Leu Gln Lys Glu Lys Phe 
465                 470                 475                 480 


Phe Ala Asn Asn Leu Pro Met Phe Tyr Asp Glu Thr Thr Leu Asp Thr 
                485                 490                 495     


Leu Leu Lys Ala Leu Tyr Lys Asn Gln Thr Ser Arg Ala Ser Gln Val 
            500                 505                 510         


Pro Ser Phe Asn Arg Val Val Val Arg Asn Asp Phe Ser Asp Phe Ile 
        515                 520                 525             


His Asp Asn Leu Lys Trp Asn Ile Ser Phe Glu Glu Asn Ser Val Ser 
    530                 535                 540                 


Arg Lys Lys Gln Phe Asp Ser Ala Leu Tyr Tyr Leu Phe Lys Glu Ile 
545                 550                 555                 560 


Tyr Tyr Asn Leu Phe Leu Gln Gly Lys Gly Leu Asn Gly Lys Phe Asp 
                565                 570                 575     


Val Lys Lys Glu Phe Ile Asn Trp Cys Asp Asp Glu Lys Asn Gly Glu 
            580                 585                 590         


Glu Asn His His Ala Phe Glu Ser Phe Thr Ser Arg Val Asn Thr Ile 
        595                 600                 605             


Asn Gly Ser Lys Asp Asp Ile Thr Leu Ala Glu Ile Cys Gln Arg Ile 
    610                 615                 620                 


Met Thr Asp Tyr Asn Leu Tyr Asn Asn Lys Ser His Lys Val Arg Ser 
625                 630                 635                 640 


Ser Phe Ala Lys Asn Lys Lys Ala Asp Asn Tyr Asp His Tyr Lys Met 
                645                 650                 655     


Leu Leu Tyr Lys Gly Leu Arg Glu Val Phe Ala Val Tyr Ile Asn Asn 
            660                 665                 670         


Val Phe His Asp Leu Glu Leu Tyr Lys Pro Ile Tyr Arg Asp Lys Pro 
        675                 680                 685             


Ser Ala Glu Asn Phe Leu Pro Asp Tyr Ser Ala Ser Thr Tyr Asp Ser 
    690                 695                 700                 


Leu Val Lys Lys Val Gln Gly Asn Ala Glu Leu Gln Lys Trp Tyr Ile 
705                 710                 715                 720 


Ile Gly Arg Leu Leu Asn Pro Arg Gln Val Asn Leu Phe Ile Gly Ser 
                725                 730                 735     


Leu Arg Gln Tyr Ile Gln Tyr Thr Glu Gln Ile Gln Arg Arg Ala Lys 
            740                 745                 750         


Asp Thr Lys Thr Lys Thr Ala Phe Leu Lys Ser Ser Lys Asn Tyr Phe 
        755                 760                 765             


Leu Tyr Glu Lys Val Leu Glu Val Cys Ile Gln Leu Ser Gly Thr Thr 
    770                 775                 780                 


Thr Asn Arg Leu Glu Asp Tyr Phe Asp Asp Glu Asp Asp Tyr Ala Arg 
785                 790                 795                 800 


His Val Ala Met Tyr Leu Asp Phe Glu Gly Ala Tyr Pro Gly Ile Asp 
                805                 810                 815     


Ile Ser Ala Gln Leu Lys Gln Phe Cys Ser Glu Asn Ile Asp Thr Ile 
            820                 825                 830         


Asn Arg Glu Thr Gly Asn Gly Pro Glu Ile Thr Asn Ile His Asp Met 
        835                 840                 845             


Asn Gly Ser Asn Glu Leu Lys Ser Leu Gly Ile Phe Tyr Asp Glu Asn 
    850                 855                 860                 


Asn Pro Ile Leu Asn Arg Asn Ile Leu Leu Ala Lys Ile Tyr Gly Thr 
865                 870                 875                 880 


Glu Arg Val Leu Ser Lys Ile Met Arg Asp Arg Lys Val Thr Lys Glu 
                885                 890                 895     


Asp Ile Leu Asp Phe Tyr Ser Gln Arg Lys Leu Ile Glu Glu Tyr Arg 
            900                 905                 910         


Ile Thr Gly Lys Cys Lys Thr Lys Asp Gln Gln Lys Ala Leu Lys Lys 
        915                 920                 925             


Tyr Gln Glu Ile Lys Asn Lys Val Glu Leu Tyr Asn Ile Val Glu Tyr 
    930                 935                 940                 


Glu Glu Ile Ile Asp Glu Ile His Ala Gln Met Ile Asp Trp Cys Tyr 
945                 950                 955                 960 


Met Arg Glu Arg Asp Leu Met Tyr Phe Gln Leu Gly Phe His Tyr Thr 
                965                 970                 975     


Cys Leu Asn Asn Asn Ser Ser Lys Ala Glu Trp Tyr Lys Arg Ile Glu 
            980                 985                 990         


His Asp Ala Arg Ile Ile Glu Gly  Ala Ile Leu Tyr Gln  Ile Ala Ala 
        995                 1000                 1005             


Met Tyr  Ile Val Gly Ile Pro  Ile Tyr Thr Phe Lys  Asp Asn Asn 
    1010                 1015                 1020             


Leu Leu  Cys Glu Pro Glu Ser  Gln Pro Val Trp Met  Lys Ile Asn 
    1025                 1030                 1035             


Arg Phe  Ile Asp Tyr Ser Ile  Gly Cys Leu Lys Gln  Ser Pro Pro 
    1040                 1045                 1050             


Phe Ser  Ser Thr Asp Arg Glu  Ile Ser Val Asp Glu  Ala Gln Ser 
    1055                 1060                 1065             


Ile Tyr  Phe Ala Gly Met Glu  Leu Phe Glu Asn Ile  Lys Glu His 
    1070                 1075                 1080             


Asp Asn  Ile Val Ala Leu Arg  Asn Tyr Ile Glu His  Phe His Tyr 
    1085                 1090                 1095             


Tyr Ala  His Leu Asp Arg Ser  Leu Leu Asp Ile Cys  Ser Glu Ile 
    1100                 1105                 1110             


Phe Asp  Arg Phe Phe Ser Tyr  Asp Leu Lys Tyr Gln  Lys Asn Val 
    1115                 1120                 1125             


Val Val  Arg Ile Tyr Asn Ile  Leu Met His His Phe  Val Lys Pro 
    1130                 1135                 1140             


Val Phe  Ala Phe Ser Thr Gly  Gln Lys Ser Val Gly  Thr Arg Lys 
    1145                 1150                 1155             


Glu Ala  Ile Thr Lys Asn Arg  Ala Thr Ile Thr Leu  Arg Gln Gly 
    1160                 1165                 1170             


Arg Gly  Leu Tyr Ser Glu Lys  Met Asn Tyr Lys Val  Tyr Lys Thr 
    1175                 1180                 1185             


Asn Asp  Ser Lys Asn Asn Asp  Lys Glu Lys Glu Lys  Lys Asn Asn 
    1190                 1195                 1200             


Asn Ser  Glu Ser Lys Asn Asn  Ser Asn Met Ile Val  Ser Glu Lys 
    1205                 1210                 1215             


Thr Thr  Leu Asp Ala Lys Ser  Arg Asp Phe Leu Asp  Gly Val Ser 
    1220                 1225                 1230             


Met Leu  Leu Thr Tyr Pro Asp  Cys Leu Arg 
    1235                 1240             


<210>  1217
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1217

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Val Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Glu Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Phe Tyr Asn Tyr Tyr Lys Asp Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Ile Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Thr Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Arg Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Glu 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Lys Ile Pro Tyr Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Ala Phe Ser Asp Gln Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Val Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Lys Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Arg Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Lys 
        915                 920                 925             


Lys Tyr Glu Lys Ala Ile Arg Asn Ile Gln Gln Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Ser Leu Leu Leu 
945                 950                 955                 960 


Arg Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Asn Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asp  Thr Glu Lys Ile Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Glu Leu  Lys Lys Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  Asn Ala Glu Val Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Ile Met Lys Ser  Ile Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Thr Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Glu 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Glu Arg Leu Met Thr  Asn Arg Asn Ser Lys  Glu Leu Cys 
    1130                 1135                 1140             


Lys Leu  Val Lys Ile Met Phe  Glu Tyr Lys Met Lys  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  1218
<211>  953
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1218

Met Lys Leu Ser Lys Glu Lys His Ile Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Val Leu Tyr His Val Leu Gly Thr Asp Thr 
            20                  25                  30          


Ile Gly Leu Lys Asp Gln Met Leu Ile Arg Asp Arg Asp Val Lys Gln 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Asp Lys Pro Lys Lys 
    50                  55                  60                  


Trp Lys Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Glu Ser Ser Gln Arg Thr Ile Asn Asp Val Leu Phe 
            100                 105                 110         


Tyr Ser Tyr Met Glu Ala Asp Lys Lys Ile Arg Asn Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Ile Lys Met Gln Glu Val Thr Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Asn Ser Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Glu Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Ser Phe Pro Gln Val Ser Asp Lys Glu Lys Lys Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ile Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Asp Lys Glu Lys Phe Asn Val Trp 
305                 310                 315                 320 


Lys Lys Tyr Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Ala Gly Arg Val Arg Arg 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Ser Leu Phe Phe Glu Asn Asp Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Met Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asp Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Tyr Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ser Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Lys Asp Arg Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Lys Glu Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Asn Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asn Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Pro Val Ser Glu Leu Arg Asn Met Leu Asp Gln Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Phe 
            660                 665                 670         


Ile Arg Lys Asn Phe Pro Glu Asp Ile Thr Asn Val Leu Arg Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Asp Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Lys Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asn Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Asn His Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Ala Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ser Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu 
865                 870                 875                 880 


Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Phe Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser 
945                 950             


<210>  1219
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1219

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  1220
<211>  1143
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1220

Met Arg Val Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Val Tyr Ser Gly 
            20                  25                  30          


Gln Pro Val Ser Asn Glu Thr Cys Asn Ile Leu Pro Glu Lys Lys Arg 
        35                  40                  45              


Gln Ser Phe Asp Leu Ser Ile Glu Asn Lys Thr Leu Lys Arg Arg Asp 
    50                  55                  60                  


Asp Val Asp Lys Thr Lys Lys Gly Lys Tyr Asp Ile Val Arg Lys Ile 
65                  70                  75                  80  


Ile Lys Tyr Gly Glu Leu Pro Gln Ser Ile Asn Asp Val Asp Ile Leu 
                85                  90                  95      


Glu Phe Leu Asn His Lys Phe Gln Lys Pro Val Lys Tyr Trp Lys Asn 
            100                 105                 110         


Gly Lys Glu Glu Ser Phe Asn Leu Thr Leu Leu Ile Val Glu Ala Val 
        115                 120                 125             


Lys Thr Gln Asp Arg Gln Lys Leu Gln Pro Tyr Tyr Asp Trp Lys Thr 
    130                 135                 140                 


Trp Tyr Ile Gln Thr Lys Ser Asp Leu Leu Lys Lys Ser Ile Glu Asn 
145                 150                 155                 160 


Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg Lys Lys Ala Leu 
                165                 170                 175     


Leu Ala Trp Glu Thr Glu Phe Thr Thr Ser Gly Lys Ile Asp Leu Thr 
            180                 185                 190         


His Tyr His Lys Val Tyr Met Thr Asp Val Leu Cys Thr Ala Leu Gln 
        195                 200                 205             


Lys Val Glu Pro Ser Thr Asp Lys Lys Gly Lys Ile Asn Thr Asn Ala 
    210                 215                 220                 


Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Thr His Gln Pro Ala Ile 
225                 230                 235                 240 


Phe Gly Thr Arg Gln Ala Pro Asn Asn Val Asn Arg Ala Asp Asp Arg 
                245                 250                 255     


Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu Glu His Tyr Phe 
            260                 265                 270         


Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Ala Asp Asp Ile Glu His 
        275                 280                 285             


Tyr Leu Lys Thr Gln Thr Leu Lys Thr Thr Ile Glu Lys Gln Leu Val 
    290                 295                 300                 


Asn Ala Ile Arg Ala Asn Ile Ile Gln Gln Gly Lys Thr Asn His His 
305                 310                 315                 320 


Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile Arg Ile Lys Thr 
                325                 330                 335     


Asn Glu Ala Phe Val Leu Asn Leu Thr Gly Thr Cys Ala Phe Ala Ala 
            340                 345                 350         


Asn Asn Ile Arg Asn Met Val Asp Asn Glu Gln Thr Asn Asp Ile Leu 
        355                 360                 365             


Gly Lys Gly Asp Phe Ile Lys Ser Leu Leu Lys Asp Asn Thr Asn Gly 
    370                 375                 380                 


Gln Leu Tyr Ser Phe Phe Phe Gly Glu Ser Leu Ser Thr Asn Lys Ala 
385                 390                 395                 400 


Glu Lys Glu Thr Gln Leu Trp Gly Ile Arg Gly Ala Val Gln Gln Ile 
                405                 410                 415     


Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu Lys Thr Val Phe 
            420                 425                 430         


Asn Ile Ser Asn Phe Glu Asn Pro Thr Ile Thr Asp Pro Lys Gln Gln 
        435                 440                 445             


Thr Asn Tyr Ala Asp Thr Ile Tyr Lys Ala Leu Phe Ile Lys Glu Leu 
    450                 455                 460                 


Glu Lys Ile Pro Asn Ala Phe Ala Gln Gln Leu Lys Thr Gly Gly Ala 
465                 470                 475                 480 


Leu Ser Tyr Tyr Thr Ile Glu Asn Leu Lys Ser Leu Leu Thr Thr Phe 
                485                 490                 495     


Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala Pro Gly Phe Lys 
            500                 505                 510         


Lys Val Phe Asn Gly Gly Ile Asn Tyr Gln Asn Ala Lys Gln Asp Glu 
        515                 520                 525             


Ser Phe Tyr Glu Leu Met Leu Glu Arg Tyr Leu Arg Lys Glu Asn Phe 
    530                 535                 540                 


Ala Glu Glu Ala Tyr Asn Ala Arg Tyr Phe Leu Leu Lys Leu Ile Tyr 
545                 550                 555                 560 


Asn Asn Leu Phe Leu Pro Gly Phe Thr Arg Asp Arg Lys Ala Phe Ala 
                565                 570                 575     


Asp Ser Val Gly Phe Val Gln Met Gln Asn Lys Lys Gln Ala Glu Lys 
            580                 585                 590         


Val Asn Pro Lys Lys Arg Glu Ala Tyr Ala Phe Glu Ala Val Arg Pro 
        595                 600                 605             


Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala Tyr Val Gln Ser 
    610                 615                 620                 


Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys Ala Thr Asp Glu 
625                 630                 635                 640 


Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val Phe Val Lys Gly 
                645                 650                 655     


Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe Val Gln Val Pro 
            660                 665                 670         


Gln Pro Gln Leu Thr Ala Thr Ala Ser Asn Gln Gln Lys Ala Asp Lys 
        675                 680                 685             


Leu Asn Gln Leu Glu Ala Ser Ile Thr Ala Asp Cys Lys Leu Thr Pro 
    690                 695                 700                 


Gln Tyr Ala Lys Ala Asp Asn Ala Thr His Ile Ala Phe Tyr Val Phe 
705                 710                 715                 720 


Cys Lys Leu Leu Asp Ala Gly His Leu Ser Asn Leu Arg Asn Glu Leu 
                725                 730                 735     


Ile Lys Phe Arg Glu Ser Val Asn Glu Phe Lys Phe His His Leu Leu 
            740                 745                 750         


Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val Val Pro Thr Asp 
        755                 760                 765             


Tyr Arg Asp Leu Tyr Ser Ser Glu Ala Asp Cys Leu Ala Arg Leu Arg 
    770                 775                 780                 


Pro Phe Ile Glu Gln Gly Ala Asp Ile Thr Asn Trp Ser Asp Leu Phe 
785                 790                 795                 800 


Val Gln Ser Asp Lys His Ser Pro Val Ile His Ala Asn Ile Glu Leu 
                805                 810                 815     


Ser Val Lys Tyr Gly Thr Thr Lys Leu Leu Glu Gln Ile Ile Asn Lys 
            820                 825                 830         


Asp Pro Gln Phe Lys Thr Thr Glu Ala Asn Phe Thr Ala Trp Asn Thr 
        835                 840                 845             


Ala Gln Lys Ser Ile Glu Gln Leu Ile Lys Gln Arg Glu Asp His His 
    850                 855                 860                 


Glu Gln Trp Val Lys Ala Lys Asn Ala Asp Asp Lys Glu Lys Gln Glu 
865                 870                 875                 880 


Arg Lys Arg Glu Lys Ser Asn Phe Ala Gln Lys Phe Ile Glu Lys His 
                885                 890                 895     


Gly Asp Asp Tyr Leu Asp Ile Cys Asp Tyr Ile Asn Thr Tyr Asn Trp 
            900                 905                 910         


Leu Asp Asn Lys Met His Phe Val His Leu Asn Arg Leu His Gly Leu 
        915                 920                 925             


Thr Ile Glu Leu Leu Gly Arg Met Ala Gly Phe Val Ala Leu Phe Asp 
    930                 935                 940                 


Arg Asp Phe Gln Met Leu Asp Ala Lys Arg Ile Ser Asp Leu Tyr Gln 
945                 950                 955                 960 


Leu Lys Ser Phe Ile Ser Phe Arg Glu Ile Thr Ser Glu Leu Asp Lys 
                965                 970                 975     


Asn Asn Asp Ile Thr Glu Ile Asn Leu Ile Lys Asp Lys Glu Ile Ile 
            980                 985                 990         


Lys Arg Asp Gly Thr Pro Ile Thr  Glu Ala Asp Arg Asn  Ser Leu Lys 
        995                 1000                 1005             


Ser Cys  Ile Gln Ser Lys Arg  Glu Tyr Tyr Gln Lys  Thr Tyr Phe 
    1010                 1015                 1020             


Lys Glu  His Thr Asn Pro Phe  Thr Asp Arg Asn Tyr  Ile Ala His 
    1025                 1030                 1035             


Phe Asn  Tyr Leu Ser Thr Asn  Thr Gly Asn His Ser  Leu Ile Lys 
    1040                 1045                 1050             


Leu Ile  Asn Lys Leu Arg Asp  Leu Leu His Tyr Asp  Arg Lys Leu 
    1055                 1060                 1065             


Lys Asn  Ala Val Ser Lys Ala  Phe Ile Asp Leu Phe  Asp Lys His 
    1070                 1075                 1080             


Gly Met  Ile Leu Lys Leu Lys  Leu Asn Thr Asp His  Gln Leu Glu 
    1085                 1090                 1095             


Val Glu  Ser Leu Glu Pro Lys  Lys Ile Tyr His Leu  Gly Ser Ser 
    1100                 1105                 1110             


Ala Lys  Asp Lys Pro Glu Tyr  Gln Tyr Cys Thr Asn  Gln Val Met 
    1115                 1120                 1125             


Met Ala  Tyr Cys Asn Met Cys  Arg Ser Leu Leu Glu  Met Lys Lys 
    1130                 1135                 1140             


<210>  1221
<211>  989
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1221

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Thr Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Leu Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Lys Ile Leu Lys Tyr Thr Glu Ser Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Ala Phe Ser Asp Gln Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Glu 
        915                 920                 925             


Asn Tyr Lys Arg Ala Ile Lys Asn Ile Glu Glu Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Arg Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln 
            980                 985                 


<210>  1222
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1222

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Tyr Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Glu 
        275                 280                 285             


Asn Val Lys Tyr Val Phe Cys His Phe Val Glu Ile Glu Met Ser Gln 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Val Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Val 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Lys Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Met 
    690                 695                 700                 


Tyr Ile Gly Asn Asp Glu Gln Ile Asn Thr Ser Leu Ala Gly Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Lys Ile Leu Lys Tyr Thr Glu Ser Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Lys Lys Asp Glu Lys Phe Asn Asp Glu Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Thr Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Glu Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Lys  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  1223
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1223

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Leu Tyr Gln Ile Val  Ser Ala Phe Asn Phe  Gly Ser Lys 
    1205                 1210                 1215             


Leu Leu  Tyr Ile Ser Glu Asp  Gly Arg Trp Lys Met  Ala Gly Gly 
    1220                 1225                 1230             


Ala Phe  Pro Gly Lys Tyr Gly  Arg Phe Glu Asn Asp  Tyr Asn His 
    1235                 1240                 1245             


Arg Thr  Ser Leu Ser Lys Val  Ile Arg Leu Phe Glu  Asn Glu Ser 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ile Ile Tyr  Trp Arg Asp Tyr Val  Asp His Met 
    1265                 1270                 1275             


Lys Tyr  Tyr Val Asn Gln Asn  Gln Ser Ile Met Glu  Ile Tyr Ser 
    1280                 1285                 1290             


Ala Phe  Tyr Ser Lys Val Leu  Gly Tyr Ser Ala Lys  Leu Arg Lys 
    1295                 1300                 1305             


Ser Val  Val Phe Asn Leu Gln  Ala Ala Leu Glu Lys  His His Ile 
    1310                 1315                 1320             


Asn Pro  Glu Cys Ile Trp Met  Thr Ser Asp Gly Lys  Cys Ala Asp 
    1325                 1330                 1335             


Ile Lys  Leu Met Lys Asn Leu  Glu Ser Gln Lys Phe  Thr Tyr Lys 
    1340                 1345                 1350             


Leu Ala  Lys Arg Glu Gly Glu  Lys Thr Glu Arg Lys  Ile Cys Met 
    1355                 1360                 1365             


Asn Ala  Leu Asn Glu Asn Phe  Leu Lys Thr Ile Arg  Thr Ser Leu 
    1370                 1375                 1380             


Glu Tyr  Lys Lys 
    1385         


<210>  1224
<211>  1254
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1224

Met Glu Gly Glu Gly Val Met Lys Leu Thr Arg Arg Arg Ile Gly Gln 
1               5                   10                  15      


Glu Arg Lys Gly Glu Lys Ile Lys Ala Ala Phe Tyr Arg Asn Ile Ser 
            20                  25                  30          


Arg Gly Leu Leu Tyr Leu Asp Ser Glu Asn Cys Asp Tyr Thr Glu Cys 
        35                  40                  45              


Val Val Glu Ala Met Asp Phe Glu Arg Ser Cys Arg Gly Arg Ile Leu 
    50                  55                  60                  


Lys Asn Ala Asp Asn Glu Lys Asn Pro Phe Tyr Lys Ile Val Lys Gly 
65                  70                  75                  80  


Leu Thr Asp Lys Asp Thr Gly Ile Phe Tyr Glu Ala Ile Val Asp Asp 
                85                  90                  95      


Gly Asn Asp Ile Asp Ile Leu Ile Asn Asn Asn Ile Thr Arg Tyr Gly 
            100                 105                 110         


Lys Glu Leu Gln Ala Pro Gly Ser Thr Val Ser Phe Glu Glu Leu Ile 
        115                 120                 125             


Arg Glu Ile Gln Ser Gly Thr Ser Lys Ser Glu Ile Ile Leu Glu Leu 
    130                 135                 140                 


Glu Lys Ile Lys Arg Met Ile Gln Asp Asp Ile Gln Lys Ser Lys Asp 
145                 150                 155                 160 


Arg Leu Ile Lys Ser Ile Ala Asn Asn Arg Ile Pro Phe Ser Leu Gln 
                165                 170                 175     


Ser Asn Gly Leu Val Pro Ser Ser Lys Lys Met Lys Trp Leu Tyr Lys 
            180                 185                 190         


Ile Leu Asp Asp Asn Asn Ile Leu Lys Lys Tyr Trp Asp Lys Tyr Glu 
        195                 200                 205             


Tyr Glu Lys Leu Glu Ser Thr Leu Ile Lys Ala Ile Glu Asp Leu Gln 
    210                 215                 220                 


Tyr Lys Asn Ala Arg Leu Ile Ser Arg Thr Val Ser Gly Ala Ile Arg 
225                 230                 235                 240 


Asp Tyr His Arg Ser Leu Lys Thr Arg Tyr Thr Asn Ser Ser Leu Glu 
                245                 250                 255     


Gly Lys Ala Arg Ser Glu His Glu Ile Asn Ser Thr Glu Asn Asn Ser 
            260                 265                 270         


Glu Lys Glu Glu Phe Leu Leu Phe Leu Lys Ala Val Glu Gln His Phe 
        275                 280                 285             


Lys Lys Tyr Phe Pro Val Lys Gly Lys His Ser Thr Asp Ala Tyr Asp 
    290                 295                 300                 


Lys Ala Leu Cys Gln Ala Glu Asn Tyr Lys Leu Tyr Cys Lys Phe Asn 
305                 310                 315                 320 


Phe Val Lys Lys Glu Val Asn Arg Ser Ile Met Asn Gln Leu Val Ser 
                325                 330                 335     


Gly Leu Ile Gln His Gly Lys Leu Ile His Tyr Phe Asn Asn Asp Gly 
            340                 345                 350         


Thr Trp Asp Val Asp Phe Leu Asn Ser His Gly Leu Ser Tyr Ile Gln 
        355                 360                 365             


Val Glu Glu Ala Phe Lys Lys Ser Leu Met Ala Ser Leu Ser Trp Gly 
    370                 375                 380                 


Ile Asn Arg Leu Thr Ser Phe Tyr Tyr Asp Ile Asn Asp Thr Arg Ile 
385                 390                 395                 400 


Asn Ser Asn Glu Glu Ser Ile Val Asp Asp Ile Leu Leu Glu Ser Lys 
                405                 410                 415     


Arg His Lys Glu Leu Arg Arg Asn Tyr Tyr Asn Asp Leu Arg Ser Asn 
            420                 425                 430         


Asp Ile Lys Gln Lys Tyr Phe Arg Glu Lys Leu Ala Ala Cys Tyr Ser 
        435                 440                 445             


Ile Ile Ala Lys Asp Asp Lys Asp Lys Ile Ser Asp Asp Ile Asn Lys 
    450                 455                 460                 


Leu Ile Gly Leu Val Glu Arg Ile Arg Lys Ser Val Ala His Ile Arg 
465                 470                 475                 480 


His Ser Ser Phe His Tyr Lys Lys Val Thr Leu Pro Glu Met Leu Asn 
                485                 490                 495     


Ala Val Asn Ile Asn Tyr Ile Arg Val Glu Glu Phe Phe Ala Arg Asp 
            500                 505                 510         


Ile Glu Asn Leu Tyr Asn Ala Phe Arg Glu Lys Ile Arg Ser Leu Gly 
        515                 520                 525             


Ile Val Glu Tyr Tyr Ser Gly Ser Asp Ile Ala Glu Cys Phe Glu Lys 
    530                 535                 540                 


Cys Gly Ile Lys Phe Thr Leu Tyr Ser Pro Gln Asn Ser Leu Ile Pro 
545                 550                 555                 560 


Ser Phe Lys Lys Ile Tyr Lys Lys Gly Val Asn Leu Asn Lys Gly Tyr 
                565                 570                 575     


Arg Ala Lys Glu Asn Gln Lys Glu Pro Asn Lys His Asn Lys His Asp 
            580                 585                 590         


Glu Gln Val Asn Arg Lys Asp Leu Leu Trp Tyr Leu Glu Ile Pro Asn 
        595                 600                 605             


Asn Glu Gln Gly Leu Leu Ala Tyr Lys Asn Leu Leu Gln Ile Ile Tyr 
    610                 615                 620                 


Tyr His Ser Phe Leu Pro Glu Val Gln Lys Asn Glu Leu Leu Ile Thr 
625                 630                 635                 640 


Asn Phe Ile Asn Asn Thr Lys Glu Trp Asn Arg Val Glu Ala Lys Lys 
                645                 650                 655     


Ile Ser Glu Arg Arg Gly Lys Lys Asn Lys Ser Ser Lys His Asn Asn 
            660                 665                 670         


Glu Lys Asp Phe Lys Ala Tyr Arg Tyr Glu Ala Ile Pro Asp Tyr Gln 
        675                 680                 685             


Gly Glu Ser Leu Asp Asp Tyr Leu Lys Ile Ile Gln Arg Glu Gln Met 
    690                 695                 700                 


Ala Gln Ala Asn Glu Met Asp Glu Gly Thr Thr Asp His Asn Tyr Tyr 
705                 710                 715                 720 


Ile Arg Phe Met Gln Asp Val Val Val Trp Ala Phe Gly Asp Tyr Leu 
                725                 730                 735     


Glu Lys Leu Met Gly Arg Tyr Arg Asp Phe Leu Gln Lys Pro Ala Leu 
            740                 745                 750         


Gln Asp Val Asp Ile Tyr Asp Ala Leu Glu Glu Leu Leu Pro Glu Asp 
        755                 760                 765             


Lys Glu Lys Gly Lys Phe Pro Met Ala Cys Arg Phe Asn Met Lys Thr 
    770                 775                 780                 


Asp Glu Asn Gly Asn Thr Ile Val Tyr Thr Phe Glu Gln Ile Lys Asp 
785                 790                 795                 800 


Gln Ile Lys Asn Arg Lys Asp Leu Leu Cys Phe Tyr Leu Phe Leu Arg 
                805                 810                 815     


Leu Leu Asp Ala Arg Glu Ile Ala Lys Leu Gln His Gln Phe Ile Arg 
            820                 825                 830         


Tyr Arg Cys Ser Leu Ile Glu Arg Arg Leu Pro Asp Gly Arg Ser Asn 
        835                 840                 845             


Gln Ile Glu Asp Glu Ile Glu Leu Phe Lys Glu Leu Glu Glu Leu Met 
    850                 855                 860                 


Glu Leu Val Arg Tyr Thr Ile Pro Glu Val His Ser Leu Tyr Gly Lys 
865                 870                 875                 880 


Lys Lys Ser Val Phe Asn Val Met Ile Gln Leu His Phe Lys Glu Phe 
                885                 890                 895     


Phe Glu Val Lys Ala Leu Lys Asn Pro Glu Val Val Asn Leu Tyr Tyr 
            900                 905                 910         


Gln Leu Asp Lys Lys Thr Pro Ile Pro Arg Lys His Met Ala Leu Leu 
        915                 920                 925             


Ile Arg Ser Val Pro Leu Pro Leu Tyr Lys Asn Met Phe Lys Asn Tyr 
    930                 935                 940                 


Tyr Cys Ile Thr Glu Asn Asp Phe Lys Glu Tyr Ile Gln Thr Ser Glu 
945                 950                 955                 960 


Val Ile Glu Glu Ile Gln Asn Lys Gln Lys Glu Leu His Lys Met Leu 
                965                 970                 975     


Glu Arg Ala Arg Leu Lys Ser Pro Asn Ile Glu Lys Met Lys Asp Lys 
            980                 985                 990         


Asn Leu Trp Tyr Ile Glu Asp Lys  Asn Val Val Glu Lys  Val Ile Glu 
        995                 1000                 1005             


Tyr Glu  Glu Asn Leu Arg Ile  Ile Ala Arg Tyr Asn  Gln Ile Lys 
    1010                 1015                 1020             


Arg Lys  Ile Thr Phe Glu Ser  Leu Tyr Arg Ile Phe  Gln Ile His 
    1025                 1030                 1035             


Val Asp  Leu Cys Ala Arg Leu  Ile Gly Tyr Thr Gln  Asp Trp Glu 
    1040                 1045                 1050             


Arg Asp  Met Tyr Phe Leu Leu  Lys Ser Leu Glu Asn  Lys Gly Ile 
    1055                 1060                 1065             


Ile Arg  Asn Asn Ile Leu Asp  Arg Ile Phe Ser Arg  Asn Ile Val 
    1070                 1075                 1080             


Arg Glu  Leu Asn Asn Ile Leu  Asn Thr Asn Glu Lys  Gly Ile Leu 
    1085                 1090                 1095             


Tyr Lys  Leu Cys Trp His Lys  Glu Leu Thr Ile Asp  Asp Met Tyr 
    1100                 1105                 1110             


Asn Lys  Met Asp Ile Arg Asn  Ser Ile Ala His Leu  Asn His Phe 
    1115                 1120                 1125             


Thr Gln  Ser Trp Asn Phe Asp  Lys Pro Ser Leu Ile  Glu Met Ile 
    1130                 1135                 1140             


Asn Ala  Leu Arg Val Leu Leu  His Tyr Asp Arg Lys  Arg Gln Asn 
    1145                 1150                 1155             


Ala Val  Leu Lys Thr Ile Asn  Asp Leu Leu Leu Lys  Asp Tyr Arg 
    1160                 1165                 1170             


Ile Lys  Ile Glu Trp Glu Arg  Lys Val His Asp Thr  Gly Glu Ile 
    1175                 1180                 1185             


Lys Phe  Asp Ile Asn Gly Asp  Val Ile Asn Glu Pro  Ile Ile His 
    1190                 1195                 1200             


Leu Lys  Asn Ile His Lys Gly  Ala Lys Cys Lys Val  Tyr Asn Lys 
    1205                 1210                 1215             


Ala Tyr  Met Ile Glu Lys Gln  Arg Glu Trp Leu Cys  Asn Gly Ile 
    1220                 1225                 1230             


Arg Glu  Glu Ile Tyr Asp Lys  Asn Phe Leu Glu Cys  Ile Glu Arg 
    1235                 1240                 1245             


Leu Phe  Lys Phe Asn Tyr 
    1250                 


<210>  1225
<211>  1254
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1225

Met Glu Gly Glu Gly Val Met Lys Leu Thr Arg Arg Arg Ile Gly Gln 
1               5                   10                  15      


Glu Arg Lys Gly Glu Lys Ile Lys Ala Ala Phe Tyr Arg Asn Ile Ser 
            20                  25                  30          


Arg Gly Leu Leu Tyr Leu Asp Ser Glu Asn Cys Asp Tyr Thr Glu Cys 
        35                  40                  45              


Val Val Glu Ala Met Asp Phe Glu Arg Ser Cys Arg Gly Arg Ile Leu 
    50                  55                  60                  


Lys Asn Ala Asp Asn Glu Lys Asn Pro Phe Tyr Lys Ile Val Lys Gly 
65                  70                  75                  80  


Leu Thr Asp Lys Asp Thr Gly Ile Phe Tyr Glu Ala Ile Val Asp Asp 
                85                  90                  95      


Gly Asn Asp Ile Asp Ile Leu Ile Asn Asn Asn Ile Thr Arg Tyr Gly 
            100                 105                 110         


Lys Glu Leu Gln Ala Pro Gly Ser Thr Val Ser Phe Glu Glu Leu Ile 
        115                 120                 125             


Arg Glu Ile Gln Ser Gly Thr Ser Lys Ser Glu Ile Ile Leu Glu Leu 
    130                 135                 140                 


Glu Lys Ile Lys Arg Met Ile Gln Asp Asp Ile Gln Lys Ser Lys Asp 
145                 150                 155                 160 


Arg Leu Ile Lys Ser Ile Ala Asn Asn Arg Ile Pro Phe Ser Leu Gln 
                165                 170                 175     


Ser Asn Gly Leu Val Pro Ser Ser Lys Lys Met Lys Trp Leu Tyr Lys 
            180                 185                 190         


Ile Leu Asp Asp Asn Asn Ile Leu Lys Lys Tyr Trp Asp Lys Tyr Glu 
        195                 200                 205             


Tyr Glu Lys Leu Glu Ser Thr Leu Ile Lys Ala Ile Glu Asp Leu Gln 
    210                 215                 220                 


Tyr Lys Asn Ala Arg Leu Ile Ser Arg Thr Val Ser Gly Ala Ile Arg 
225                 230                 235                 240 


Asp Tyr His Arg Ser Leu Lys Thr Arg Tyr Thr Asn Ser Ser Leu Glu 
                245                 250                 255     


Gly Lys Ala Arg Ser Glu His Glu Ile Asn Ser Thr Glu Asn Asn Ser 
            260                 265                 270         


Glu Lys Glu Glu Phe Leu Leu Phe Leu Lys Ala Val Glu Gln His Phe 
        275                 280                 285             


Lys Lys Tyr Phe Pro Val Lys Gly Lys His Ser Thr Asp Ala Tyr Asp 
    290                 295                 300                 


Lys Ala Leu Cys Gln Ala Glu Asn Tyr Lys Leu Tyr Cys Lys Phe Asn 
305                 310                 315                 320 


Phe Val Lys Lys Glu Val Asn Arg Ser Ile Met Asn Gln Leu Val Ser 
                325                 330                 335     


Gly Leu Ile Gln His Gly Lys Leu Ile His Tyr Phe Asn Asn Asp Gly 
            340                 345                 350         


Thr Trp Asp Val Asp Phe Leu Asn Ser His Gly Leu Ser Tyr Ile Gln 
        355                 360                 365             


Val Glu Glu Ala Phe Lys Lys Ser Leu Met Ala Ser Leu Ser Trp Gly 
    370                 375                 380                 


Ile Asn Arg Leu Thr Ser Phe Tyr Tyr Asp Ile Asn Asp Thr Arg Ile 
385                 390                 395                 400 


Asn Ser Asn Glu Glu Ser Ile Val Asp Asp Ile Leu Leu Glu Ser Lys 
                405                 410                 415     


Arg His Lys Glu Leu Arg Arg Asn Tyr Tyr Asn Asp Leu Arg Ser Asn 
            420                 425                 430         


Asp Ile Lys Gln Lys Tyr Phe Arg Glu Lys Leu Ala Ala Cys Tyr Ser 
        435                 440                 445             


Ile Ile Ala Lys Asp Asp Lys Asp Lys Ile Ser Asp Asp Ile Asn Lys 
    450                 455                 460                 


Leu Ile Gly Leu Val Glu Arg Ile Arg Lys Ser Val Ala His Ile Arg 
465                 470                 475                 480 


His Ser Ser Phe His Tyr Lys Lys Val Thr Leu Pro Glu Met Leu Asn 
                485                 490                 495     


Ala Val Asn Ile Asn Tyr Ile Arg Val Glu Glu Phe Phe Ala Arg Asp 
            500                 505                 510         


Ile Glu Asn Leu Tyr Asn Ala Phe Arg Glu Lys Ile Arg Ser Leu Gly 
        515                 520                 525             


Ile Val Glu Tyr Tyr Ser Gly Ser Asp Ile Ala Glu Cys Phe Glu Lys 
    530                 535                 540                 


Cys Gly Ile Lys Phe Thr Leu Tyr Ser Pro Gln Asn Ser Leu Ile Pro 
545                 550                 555                 560 


Ser Phe Lys Lys Ile Tyr Lys Lys Gly Val Asn Leu Asn Lys Gly Tyr 
                565                 570                 575     


Arg Ala Lys Glu Asn Gln Lys Glu Pro Asn Lys His Asn Lys His Asp 
            580                 585                 590         


Glu Gln Val Asn Arg Lys Asp Leu Leu Trp Tyr Leu Glu Ile Pro Asn 
        595                 600                 605             


Asn Glu Gln Gly Leu Leu Ala Tyr Lys Asn Leu Leu Gln Ile Ile Tyr 
    610                 615                 620                 


Tyr His Ser Phe Leu Pro Glu Val Gln Lys Asn Glu Leu Leu Ile Thr 
625                 630                 635                 640 


Asn Phe Ile Asn Asn Thr Lys Glu Trp Asn Arg Val Glu Ala Lys Lys 
                645                 650                 655     


Ile Ser Glu Arg Arg Gly Lys Lys Asn Lys Ser Ser Lys His Asn Asn 
            660                 665                 670         


Glu Lys Asp Phe Lys Ala Tyr Arg Tyr Glu Ala Ile Pro Asp Tyr Gln 
        675                 680                 685             


Gly Glu Ser Leu Asp Asp Tyr Leu Lys Ile Ile Gln Arg Glu Gln Met 
    690                 695                 700                 


Ala Gln Ala Asn Glu Met Asp Glu Gly Thr Thr Asp His Asn Tyr Tyr 
705                 710                 715                 720 


Ile Arg Phe Met Gln Asp Val Val Val Trp Ala Phe Gly Asp Tyr Leu 
                725                 730                 735     


Glu Lys Leu Met Gly Arg Tyr Arg Asp Phe Leu Gln Lys Pro Ala Leu 
            740                 745                 750         


Gln Asp Val Asp Ile Tyr Asp Ala Leu Glu Glu Leu Leu Pro Glu Asp 
        755                 760                 765             


Lys Glu Lys Gly Lys Phe Pro Met Ala Cys Arg Phe Asn Met Lys Thr 
    770                 775                 780                 


Asp Glu Asn Gly Asn Thr Ile Val Tyr Thr Phe Glu Gln Ile Lys Asp 
785                 790                 795                 800 


Gln Ile Lys Asn Arg Lys Asp Leu Leu Cys Phe Tyr Leu Phe Leu Arg 
                805                 810                 815     


Leu Leu Asp Ala Arg Glu Ile Ala Lys Leu Gln His Gln Phe Ile Arg 
            820                 825                 830         


Tyr Arg Cys Ser Leu Ile Glu Arg Arg Leu Pro Asp Gly Arg Ser Asn 
        835                 840                 845             


Gln Ile Glu Asp Glu Ile Glu Leu Phe Lys Glu Leu Glu Glu Leu Met 
    850                 855                 860                 


Glu Leu Val Arg Tyr Thr Ile Pro Glu Val His Ser Leu Tyr Gly Lys 
865                 870                 875                 880 


Lys Lys Ser Val Phe Asn Val Met Ile Gln Leu His Phe Lys Glu Phe 
                885                 890                 895     


Phe Glu Val Lys Ala Leu Lys Asn Pro Glu Val Val Asn Leu Tyr Tyr 
            900                 905                 910         


Gln Leu Asp Lys Lys Thr Pro Ile Pro Arg Lys His Met Ala Leu Leu 
        915                 920                 925             


Ile Arg Ser Val Pro Leu Pro Leu Tyr Lys Asn Met Phe Lys Asn Tyr 
    930                 935                 940                 


Tyr Cys Ile Thr Glu Asn Asp Phe Lys Glu Tyr Ile Gln Thr Ser Glu 
945                 950                 955                 960 


Val Ile Glu Glu Ile Gln Asn Lys Gln Lys Glu Leu His Lys Met Leu 
                965                 970                 975     


Glu Arg Ala Arg Leu Lys Ser Pro Asn Ile Glu Lys Met Lys Asp Lys 
            980                 985                 990         


Asn Leu Trp Tyr Ile Glu Asp Lys  Asn Val Val Glu Lys  Val Ile Glu 
        995                 1000                 1005             


Tyr Glu  Glu Asn Leu Arg Ile  Ile Ala Arg Tyr Asn  Gln Ile Lys 
    1010                 1015                 1020             


Arg Lys  Ile Thr Phe Glu Ser  Leu Tyr Arg Ile Phe  Gln Ile His 
    1025                 1030                 1035             


Val Asp  Leu Cys Ala Arg Leu  Ile Gly Tyr Thr Gln  Asp Trp Glu 
    1040                 1045                 1050             


Arg Asp  Met Tyr Phe Leu Leu  Lys Ser Leu Glu Asn  Lys Gly Ile 
    1055                 1060                 1065             


Ile Arg  Asn Asn Ile Leu Asp  Arg Ile Phe Ser Arg  Asn Ile Val 
    1070                 1075                 1080             


Arg Glu  Leu Asn Asn Ile Leu  Asn Thr Asn Glu Lys  Gly Ile Leu 
    1085                 1090                 1095             


Tyr Lys  Leu Cys Trp His Lys  Glu Leu Thr Ile Asp  Asp Met Tyr 
    1100                 1105                 1110             


Asn Lys  Met Asp Ile Arg Asn  Ser Ile Ala His Leu  Asn His Phe 
    1115                 1120                 1125             


Thr Gln  Ser Trp Asn Phe Asp  Lys Pro Ser Leu Ile  Glu Met Ile 
    1130                 1135                 1140             


Asn Ala  Leu Arg Val Leu Leu  His Tyr Asp Arg Lys  Arg Gln Asn 
    1145                 1150                 1155             


Ala Val  Leu Lys Thr Ile Asn  Asp Leu Leu Leu Lys  Asp Tyr Arg 
    1160                 1165                 1170             


Ile Lys  Ile Glu Trp Glu Arg  Lys Val His Asp Thr  Gly Glu Ile 
    1175                 1180                 1185             


Lys Phe  Asp Ile Asn Gly Asp  Val Ile Asn Glu Pro  Ile Ile His 
    1190                 1195                 1200             


Leu Lys  Asn Ile His Lys Gly  Ala Lys Cys Lys Val  Tyr Asn Lys 
    1205                 1210                 1215             


Ala Tyr  Met Ile Glu Lys Gln  Arg Glu Trp Leu Cys  Asn Gly Ile 
    1220                 1225                 1230             


Arg Glu  Glu Ile Tyr Asp Lys  Asn Phe Leu Glu Cys  Ile Glu Arg 
    1235                 1240                 1245             


Leu Phe  Lys Phe Asn Tyr 
    1250                 


<210>  1226
<211>  1184
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1226

Met Arg Val Ser Lys Val Lys Val Leu Gly Asn Glu Glu Thr Lys Gly 
1               5                   10                  15      


Arg Ile Val Leu Met His Arg Ser Pro Val Lys Gly Gln Leu Ile Tyr 
            20                  25                  30          


Ser Glu Asp Ala Gly Lys Arg Asp Arg Thr Glu Asp Ile Ile Pro Glu 
        35                  40                  45              


Gln Lys Leu Glu Ser Phe His Leu Ser Ile Leu Asn Lys Thr Phe Leu 
    50                  55                  60                  


Arg Lys Glu Phe Phe Lys Lys Glu Leu Lys His Glu Ala Lys Lys Asn 
65                  70                  75                  80  


Gly Leu Lys Gly Asp Ala Glu Asp Lys Tyr Ile Ser Glu Lys Leu Lys 
                85                  90                  95      


Glu Tyr His Ser Leu Leu Gln Phe Ile Asp Asp Val Leu Ser Val Lys 
            100                 105                 110         


Tyr Asn Glu Asn Arg Lys Ala Ile Lys Phe Pro Glu Tyr Leu Thr Arg 
        115                 120                 125             


Glu Met Ile Glu Ile Phe Leu Asn His Lys Phe Arg Lys Glu Val Thr 
    130                 135                 140                 


Tyr Thr Asn Lys Asn Gly Ala Ser Val Ser Phe Leu Leu Ser Thr Leu 
145                 150                 155                 160 


Ile Leu Asn Ala Ile Glu Lys His Ser Val Ile Glu Met Gln Pro Phe 
                165                 170                 175     


Val Asp Trp Arg Asn Trp Phe Val Glu Thr Lys Ser Lys Phe Leu Lys 
            180                 185                 190         


Lys Ser Ile Ile Asn Asn Cys Ile Pro Thr Asn Gly Gly Pro Ile Ser 
        195                 200                 205             


Arg Arg Arg Glu Thr Leu Met Lys Trp Arg Asp Asp Tyr Phe Thr Asn 
    210                 215                 220                 


Ala Glu Ile Asp Leu Ala Arg Leu His Lys Lys Phe Gly Thr Asp Thr 
225                 230                 235                 240 


Leu Met Ala Ser Leu Arg Glu Val Pro Gln Thr Glu Lys Ser Gly Asn 
                245                 250                 255     


Glu Tyr His Arg Leu Leu Lys Ser Cys Leu Gln Ser His Gln Lys Lys 
            260                 265                 270         


Leu Phe Gly Lys Arg Ala Glu Gly Tyr Asp Ile Asn Arg Ala Asp Asn 
        275                 280                 285             


Gln Leu Tyr Val Tyr Asn Thr Glu Val Val Lys Tyr Met Glu His Tyr 
    290                 295                 300                 


Phe Pro Val Lys Ser Ser Lys Arg Arg Asn Ser Thr Ala Glu Ile Lys 
305                 310                 315                 320 


Tyr Tyr Leu Gln Thr Asp Thr Ile Lys Cys Cys Leu His His Gln Ile 
                325                 330                 335     


Ile Asn Ala Val Arg Gly Leu Ala Leu Arg Glu Gly Lys Phe Asn Leu 
            340                 345                 350         


His Gly Phe Asp Asp Lys Leu Ile Pro Asn Glu Arg Asn Val Ser Ser 
        355                 360                 365             


Ser Ile Leu Asn Glu Leu Lys Thr Ser Glu Gly Phe Val Leu Asn Met 
    370                 375                 380                 


Leu Gly Gly Cys Ala Phe Ala Ala Asn Cys Leu Arg Asn Ile Val Asp 
385                 390                 395                 400 


Ala Thr Gln Arg Ser Asp Leu Leu Gly Phe Arg Cys Phe Glu Val Ser 
                405                 410                 415     


Leu Lys Lys Gly Lys Ser Asn Ser Asp Leu Phe Ala Leu Phe Phe Gly 
            420                 425                 430         


Phe Gly Arg Glu Asp Met Asp Asp Asp Ser Glu Trp Glu Lys His Leu 
        435                 440                 445             


Tyr Ala Ala Arg Tyr Ser Val Ser Glu Ile Arg Asn Arg Val Ala His 
    450                 455                 460                 


Tyr His Lys Ser Ala Ile Glu Asn Ile Tyr Asn Ile Thr Asp Phe Glu 
465                 470                 475                 480 


Tyr Arg Glu Asn Ser Met Cys Ser Tyr Thr Asp Thr Lys Phe Thr Thr 
                485                 490                 495     


Ala Leu Gln Asn Glu Ile Tyr Asn Thr Pro Lys Ala Phe Ser Leu Gln 
            500                 505                 510         


Leu Met Thr Gly Lys Val Leu Glu Tyr Tyr Pro Lys Glu Lys Leu Val 
        515                 520                 525             


Ser Phe Phe Gln Lys Tyr Lys Phe Ser Leu Tyr Arg Ser Val Val Pro 
    530                 535                 540                 


Phe Ala Pro Gly Phe Lys Asn Ile Met Arg Thr Gly Val Asn Tyr Gln 
545                 550                 555                 560 


Asn Ala Thr Gln Asn Arg Leu Phe Tyr Asp Met Gly Leu Thr Ala Phe 
                565                 570                 575     


Gln Asp Lys Asp Arg Tyr Ile Asp Asp Val Glu Ala Trp Asn Ala Arg 
            580                 585                 590         


Tyr Phe Phe Met Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Arg Phe 
        595                 600                 605             


Thr Asn Asp Lys Asn Asp Leu Phe Arg Lys Thr Val Glu Gln Val Leu 
    610                 615                 620                 


Glu Val Asn Arg Ser His Met Glu Lys Val Gly Lys Asp Asp Arg Gln 
625                 630                 635                 640 


Ala Phe Gly Glu Val Arg Gln Met Arg Glu Asn Glu Thr Ala Asn Asp 
                645                 650                 655     


Tyr Met Ala Tyr Leu Gln Ser Ser Leu Arg Met Glu Lys Asn Lys Lys 
            660                 665                 670         


Glu Leu Glu Gly Asn Gly Ala Lys Arg Ile Asn Phe Glu Lys Phe Ile 
        675                 680                 685             


Leu Gln Met Phe Val Lys Gly Phe Asp Ser Phe Leu Lys Asp Gly Ala 
    690                 695                 700                 


Phe Glu Phe Val His Ser Pro Glu Asn Cys Leu Thr Gly Ser Thr Glu 
705                 710                 715                 720 


Lys Glu Arg Ala Lys Glu Arg Asn Ser Leu Cys Glu Glu Ile Gly Asn 
                725                 730                 735     


Tyr Val Arg Leu Val Ser Thr Val Ile Asp Pro Gly Lys Gly Ser His 
            740                 745                 750         


Val Ala Phe Tyr Val Phe Cys Lys Met Leu Asn Ser Val Tyr Leu Ser 
        755                 760                 765             


Asn Ile Arg Asn Glu Met Ile Lys Tyr His Lys Val Val Arg Thr Asp 
    770                 775                 780                 


Glu Leu Ala His Leu Ile Glu Ile Ile Glu Leu Cys Leu Leu Ser Ala 
785                 790                 795                 800 


Asp Ala Val Ser Gln Lys Thr Val Asn Ala Asp Lys Leu Ser His Phe 
                805                 810                 815     


Phe Ala Glu Gly Val Asn Val Asp Asp Asp Glu Asn Val Ile His Ala 
            820                 825                 830         


Ser Met Glu Thr Phe Arg Lys Tyr Gly Thr Arg Asp Leu Phe His Lys 
        835                 840                 845             


Leu Met Leu Gln Asp Asp Arg Phe Leu Val Ser Ser Asp Asp Tyr Arg 
    850                 855                 860                 


Glu Trp Glu Glu Met Lys Glu Lys Ile Glu Gly Lys Val Lys Gln Arg 
865                 870                 875                 880 


Glu Leu Leu His Ala Glu Trp Cys Glu Ala Lys Glu Lys Asp Lys Lys 
                885                 890                 895     


Ser Arg Lys Val Lys Ser Asn Ser Arg Thr Cys Phe Glu Lys Lys Phe 
            900                 905                 910         


Met Gly Ala Lys Ala Glu Glu Tyr Tyr Ser Leu Cys Asn Val Ile Asp 
        915                 920                 925             


Lys Tyr Asn Trp Leu Asp Asn Lys Leu His Leu Val His Leu Asn Lys 
    930                 935                 940                 


Leu His Asn Leu Val Ile Glu Ile Leu Gly Arg Met Val Gly Phe Thr 
945                 950                 955                 960 


Ala Leu Phe Glu Arg Asp Phe Gln Tyr Ile Cys Lys Ser Asp Ser Glu 
                965                 970                 975     


Tyr Glu Gln Leu Tyr Asn Leu Asp Phe Asn Met Gly Leu Pro Lys Phe 
            980                 985                 990         


Lys Asn Ser Ile Lys Gly Ser Gly  Lys Ala Lys Asn Ser  Thr Gln Asn 
        995                 1000                 1005             


Ile Asp  His Asn Ala Thr Gly  Ile Gly Asn Ser Ser  Asn Leu Leu 
    1010                 1015                 1020             


Lys Glu  Asn Ser Asn Gly Thr  His Tyr Cys Lys Asn  Leu Ser Gly 
    1025                 1030                 1035             


Asp Gly  Val Glu Asp Lys Leu  Lys Arg Leu Phe Leu  Tyr Asp Asp 
    1040                 1045                 1050             


Tyr Arg  Asn Val Arg Asn Phe  Val Ala His Phe Asn  Tyr Leu Thr 
    1055                 1060                 1065             


Arg Val  Glu Asp Asp Leu Gly  Gly Asn Asp Ala Val  Lys Leu Ser 
    1070                 1075                 1080             


Gly Thr  Arg Tyr Ser Leu Ile  Glu Leu Ile Asn Glu  Leu Arg Asn 
    1085                 1090                 1095             


Leu Leu  Lys Tyr Asp Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ser 
    1100                 1105                 1110             


Phe Ile  Asp Met Phe Glu Arg  His Gly Met His Val  Lys Met Lys 
    1115                 1120                 1125             


Leu Asn  His Asn His Lys Leu  Phe Val Asp Ser Ile  Ser Pro Arg 
    1130                 1135                 1140             


Lys Ile  Lys His Leu Gly Gly  Gly Tyr Lys Lys Arg  Gly Lys Asp 
    1145                 1150                 1155             


Asp Lys  Met Tyr Val Gln Thr  Thr Asn His Val Asp  Pro Leu Tyr 
    1160                 1165                 1170             


Cys Asp  Met Cys Arg Ala Leu  Leu Glu Met Lys 
    1175                 1180                 


<210>  1227
<211>  1221
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1227

Met Leu Ile Ile Lys Pro Tyr Gly Arg Ser His Val Glu Thr Thr Ala 
1               5                   10                  15      


Glu Ser Arg Lys Arg Val Leu Arg Leu Thr Asp Ala Pro Asp Ile Pro 
            20                  25                  30          


Gln Asp Ile Lys Asp Phe Ala His Thr Asp Pro Arg Leu Val Ile Ala 
        35                  40                  45              


Gln Trp Ile Ser Ala Ile Asp Lys Ile Ala Thr Lys Pro Gln Gly Asp 
    50                  55                  60                  


Gly Gly Ala Thr Glu Glu Gln Arg Ala Leu Arg Lys Lys Leu Gly Asn 
65                  70                  75                  80  


Ala Ala Trp Ala His Ile Arg Ala Asn Gly Leu Val Ser Glu Leu Gln 
                85                  90                  95      


Asp Asp Glu His Ala Lys Tyr Leu Thr Thr Leu Trp Trp Ser Lys Ile 
            100                 105                 110         


Glu Pro Tyr Gly Asp Gln Asn Tyr Lys Gly Lys Arg Lys Pro Pro Ser 
        115                 120                 125             


Pro Lys Gly Arg Trp Tyr Lys Arg Phe Ala Gly Glu Ala Glu Pro His 
    130                 135                 140                 


Glu Ile Asn Ala Pro Lys Met Val Glu Gln Leu His Glu His Leu Tyr 
145                 150                 155                 160 


Glu Ala Glu Tyr Arg Leu Asp Pro Asp Ala Lys Lys Lys Arg Leu Gly 
                165                 170                 175     


Arg Ile Ala Ala Arg Ala Asp Ser Ile Glu Gln Asn Val Leu Lys Pro 
            180                 185                 190         


Pro Ala Gln Met Asn Ala Thr Trp Asp Glu Ser Asp Glu Ala Ala Tyr 
        195                 200                 205             


Val Lys Gly Val Asp Val Ala Arg Thr Ile Tyr Asn Leu Ala Lys Lys 
    210                 215                 220                 


Leu Ala Asp Asn Lys Asp Lys Ser Gly Lys Ser Gly Pro Arg Arg Met 
225                 230                 235                 240 


Asn Pro Lys Asp Ala Gly Ala Glu Leu Tyr Val His Tyr Gly Arg Leu 
                245                 250                 255     


Phe Arg Asp Glu Lys Gly Asn Val Leu Thr Ile Glu Cys Ala Arg Lys 
            260                 265                 270         


Gln His Ala Gly Leu Phe Asn Leu His Met Ala Val Lys Asp Phe Tyr 
        275                 280                 285             


Thr Arg Arg Leu Lys His Asn Lys Arg Lys Glu Asn Thr Pro His Ser 
    290                 295                 300                 


Leu Pro Thr Asn Gly Asp Ala Leu Phe Ala Leu Leu Lys Lys Gly Gln 
305                 310                 315                 320 


Arg Asn Arg Asp Val Asn Ser Leu Val Arg Leu Gly Lys Val Ile His 
                325                 330                 335     


Tyr Glu Met Ser Lys Gln Val Trp Gln Ala Asp Val Pro Leu Asp Asp 
            340                 345                 350         


Pro Ala Gln Glu Gln Thr Arg Leu Asn Gly Leu Met Lys Gln Trp Ser 
        355                 360                 365             


Ser Ala Asp Arg Phe Lys Ala His Trp Pro Asp Ala Ile Asn Asp Ser 
    370                 375                 380                 


His Phe Trp Thr Ser Asp Gly Gln Ser Glu Ile Gln Arg His Glu Ala 
385                 390                 395                 400 


Phe Val Arg Ile Trp Arg His Thr Ile Ala Phe Ala Asn Arg Thr Leu 
                405                 410                 415     


Thr Asp Trp Val Tyr Pro Gly Asp His Ile Asp His Asp Ile Phe Glu 
            420                 425                 430         


Gly Lys Lys Ile Asp Asn Ala Val Ala Arg Val Ser Asp Glu Gln His 
        435                 440                 445             


Arg Arg Lys Leu Asp Leu Leu Phe Gly Lys Arg Val Pro Asp Leu Leu 
    450                 455                 460                 


Ala His Ser Asp Gly Ala Arg Leu Leu Thr Ala Ala Ile Gln Arg Ala 
465                 470                 475                 480 


Ala Tyr Leu Arg Asn Arg Ser Leu His Phe Thr Asp Lys Arg Val Phe 
                485                 490                 495     


Ala Thr Ala Leu Ser Arg Leu Ser Asp Gly Val Ser Asn Gln Val Lys 
            500                 505                 510         


Ser Ala Leu Arg Thr Leu Trp Gln Ala Asp Gln Asp Asp Gln Ala Val 
        515                 520                 525             


Ser Leu Lys Lys Thr Met Thr Ala Ser His Ser Pro Ala Tyr Phe Asp 
    530                 535                 540                 


Glu Glu Lys Asn Arg Gln Leu Phe Glu Ala Ile Ile Thr Thr Ala Pro 
545                 550                 555                 560 


Ser Leu Leu Val Leu Pro Arg Phe Arg Arg Ile Leu Ala Arg Ala Gly 
                565                 570                 575     


Asp Pro Trp Glu Lys Glu Glu Glu Arg Pro Ile Leu Pro Leu Pro Ala 
            580                 585                 590         


Asn Arg Gln Ala Leu Glu Asp Pro Ala Arg Leu Cys Gln Tyr Ser Leu 
        595                 600                 605             


Ser Lys Met Leu Tyr Glu Arg Pro Phe Arg His Trp Leu Asp Thr Arg 
    610                 615                 620                 


Gln Ser Ser Ala Ile Asn Ala Tyr Ile Glu Lys Ala Ile Ala Arg Ser 
625                 630                 635                 640 


Thr Trp Ala Ala Gln Glu Lys Asn Gly Gly Asp Lys Ser Glu Glu Glu 
                645                 650                 655     


Lys Ala Leu Ile Val Ser Lys Gln Ser Ser Leu Pro Arg Leu Asp Thr 
            660                 665                 670         


Glu Thr Gly Gly Ala His Ile Arg His Phe Phe Phe Arg Leu Ser Ala 
        675                 680                 685             


Ala Thr Ala Thr Glu Met Arg Val Gln Lys Gly Tyr Ala Ser Asn Ala 
    690                 695                 700                 


Glu Asn Ala Lys Ala Gln Ala Ser Tyr Ile Glu Lys Leu Lys Cys Thr 
705                 710                 715                 720 


Val Val Ala Leu Ala Phe Ala Asp Tyr Leu Ala Glu Ala Gly Phe Gly 
                725                 730                 735     


Phe Leu Leu Ser Leu Lys Pro Glu Thr Pro Leu Arg Asp Ser Gln Cys 
            740                 745                 750         


Asp Leu Asp Gly Leu Ser Ile Pro Ala Ser Ala Leu Glu Glu Asp Ala 
        755                 760                 765             


Gly Gln Pro Thr Gln Asp Trp Gln Thr Val Leu Tyr Phe Leu Leu His 
    770                 775                 780                 


Leu Val Pro Val Asp Glu Ala Asn Lys Leu Leu His Gln Val Arg Lys 
785                 790                 795                 800 


Trp Gln Val Leu Glu Ala Lys Pro His Gln Gly Pro Ile Thr Glu Lys 
                805                 810                 815     


Thr Lys Lys Pro Asn Gly Asp Pro Thr Ile Met Gly Thr Val Lys Ala 
            820                 825                 830         


Leu Glu Leu Tyr Leu Ser Met His Asp Ala Lys Phe Glu Gly Gly Met 
        835                 840                 845             


Ala Leu Val Gly Thr Glu Gly Phe Lys Thr Phe Tyr Glu Ser Glu Ala 
    850                 855                 860                 


Gly Phe Ala Arg Val Phe Ser Asn Pro Asp Asp Thr Ser Asp His Thr 
865                 870                 875                 880 


Val Pro Arg Arg Gly Leu Arg Glu Ile Met Arg Phe Gly His Leu Pro 
                885                 890                 895     


Leu Leu Gln Gln Ile Cys Ser Asp Gly Gln Val Thr Asp Ala Gln Ile 
            900                 905                 910         


Ala Thr Trp Gln Gln Glu Arg Ser Ala Thr Glu Gly Leu Ser Pro Ile 
        915                 920                 925             


Ala Ile His Gln His Ala Arg Glu Ala Leu His Ala Thr Tyr Thr Glu 
    930                 935                 940                 


Thr Thr Lys Lys Phe Pro Ile Glu Lys Val Arg Asp Tyr Ala Glu Ala 
945                 950                 955                 960 


Leu Ala Phe Val Ser Lys His Arg Leu Leu Ala Ala Gln Val Thr Leu 
                965                 970                 975     


Thr Asn His Val Arg Ala His Arg Leu Met Met Ala Ala Leu Ala Arg 
            980                 985                 990         


Leu Ala Asp Tyr Ala Gly Leu Trp  Glu Arg Asp Leu Tyr  Phe Val Thr 
        995                 1000                 1005             


Leu Ala  Leu Met His Gln His  Asn Leu His Pro Thr  Gln Ile Phe 
    1010                 1015                 1020             


Cys Asp  Glu Gly Leu Gly Leu  Leu Ala Gly Arg Gln  Ala Ile Thr 
    1025                 1030                 1035             


Ala Gln  Arg His Met Met Ser  Arg Glu Asp Arg Asn  Pro Val Arg 
    1040                 1045                 1050             


Ala Asp  Ile Cys Val Tyr Phe  Gly Ala Val His Glu  Lys Asp Asn 
    1055                 1060                 1065             


Pro Leu  Val Asn Ala Arg His  Asn Leu Ala His Phe  Asn Met Leu 
    1070                 1075                 1080             


Arg Gly  Gln Asp Leu Asn Leu  Thr Glu Leu Val Asn  Glu Thr Arg 
    1085                 1090                 1095             


Gln Leu  Met Ala His Asp Arg  Lys Leu Lys Asn Ala  Val Ser Gln 
    1100                 1105                 1110             


Ser Ile  Arg Glu Leu Leu Gly  Arg Glu Gly Ile Glu  Leu Ser Trp 
    1115                 1120                 1125             


Lys Met  Asn Ala Asp Ala Thr  Pro His Gln Leu His  Gly Ala Gln 
    1130                 1135                 1140             


Leu Ser  Ala Gln Arg Ala Lys  His Leu Gln Asp Arg  Lys Asp Ile 
    1145                 1150                 1155             


Thr Pro  Pro Leu Trp Glu Glu  Leu His Gly Thr Glu  Phe Val Asp 
    1160                 1165                 1170             


Met Ile  Gly Arg Leu Phe Asp  Gly Thr Arg Asp Glu  Gln Lys Gln 
    1175                 1180                 1185             


Ala Asp  Val Thr Ala Leu Asp  Ile Ala Gln Leu His  Ile Glu His 
    1190                 1195                 1200             


Lys Arg  Gly Gly Gln Arg Arg  Arg Glu Ser Gly Ser  Phe Ser Lys 
    1205                 1210                 1215             


Gln Arg  Gln 
    1220     


<210>  1228
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1228

Met Lys Ile Thr Lys Ile Asp Gly Ile Ser His Lys Lys Tyr Ile Lys 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Lys Thr Asp Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Thr Ile Arg Leu Asp Thr Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Glu Phe Phe Ser Asn Lys Val Leu Tyr Leu Lys Asp Gly Ile Leu 
65                  70                  75                  80  


Tyr Leu Lys Asp Arg Arg Glu Lys Asn Gln Leu Gln Asn Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Asn Phe 
            100                 105                 110         


Leu Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Asn Asp Phe Glu Lys Lys Leu Asp Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Leu Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Ile Lys Lys Val Glu Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Phe Tyr Asn Tyr Tyr Lys Asp Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Ile Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Asn Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Thr Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Met 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asn Val Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asn Lys Glu Lys Leu Asn Asp Glu 
        275                 280                 285             


Asn Ile Lys Tyr Val Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Ile Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Ser Phe Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Val Gly Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Ala Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Ile Lys Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Ile Ser Gly Glu Ile Asp Lys Leu Tyr Asp 
            420                 425                 430         


Asn Asn Lys Gln Asn Glu Val Lys Lys Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Ser Lys Asn Glu Ile Glu Asp Phe Phe Ser 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Lys Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Cys Ile Tyr Trp 
                565                 570                 575     


Lys Ile Pro Lys Ala Asn Asp Asn Asn Lys Thr Lys Glu Ile Thr Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ile Lys Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asn Leu Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Phe Tyr Met Ile Asp Ala Gly Asn Lys Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Ala Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Met 
    690                 695                 700                 


Tyr Ile Gly Asn Asp Glu Gln Ile Asn Thr Ser Leu Ala Gly Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Lys Ile Leu Lys Tyr Ser Glu Ser Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Ala Phe Ser Asp Gln Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Val Lys Asp Asn Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Ala Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Lys 
        915                 920                 925             


Lys Tyr Glu Lys Ala Ile Arg Asn Ile Gln Gln Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Ser Leu Leu Leu 
945                 950                 955                 960 


Arg Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Asn Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asp  Thr Glu Lys Ile Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Glu Leu  Lys Lys Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  Asn Ala Glu Val Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Ile Met Lys Ser  Ile Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Thr Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Glu 
    1100                 1105                 1110             


Ile Gln  Ser Leu Lys Ser Glu  Glu Ile Val His Leu  Lys Lys Leu 
    1115                 1120                 1125             


Lys Leu  Lys Asp Asn Asp Lys  Lys Lys Glu Pro Ile  Lys Ile Tyr 
    1130                 1135                 1140             


Arg Asn  Ser Lys Glu Leu Cys  Glu Leu Val Lys Val  Met Phe Glu 
    1145                 1150                 1155             


Tyr Lys  Met Lys Glu Lys Lys  Ser Glu Asn 
    1160                 1165             


<210>  1229
<211>  1135
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1229

Met Lys Ile Thr Lys Ile Gly Gly Ile Ser His Lys Lys Tyr Glu Glu 
1               5                   10                  15      


Lys Gly Lys Leu Ile Lys Ser Asn Glu Ile Glu Lys Asp Val Ile Glu 
            20                  25                  30          


Glu Arg Phe Ser Asn Ile Glu Ala Lys Thr Thr Glu Leu Phe Ser Lys 
        35                  40                  45              


Thr Leu Asp Phe Tyr Val Lys Asn Tyr Glu Lys Cys Glu Glu Gln Asn 
    50                  55                  60                  


Lys Glu Arg Arg Glu Lys Ala Lys Asn Tyr Phe Ser Lys Val Lys Leu 
65                  70                  75                  80  


Ile Val Asp Asn Lys Lys Ile Thr Ile Phe Asn Glu Asn Thr Glu Lys 
                85                  90                  95      


Ile Glu Ile Glu Gly Phe Asn Glu Tyr Asp Val Arg Asp Glu Lys Tyr 
            100                 105                 110         


Phe Asn Val Leu Asn Lys Ile Leu Lys Glu Glu Asn Cys Thr Glu Glu 
        115                 120                 125             


Asp Leu Glu Val Phe Glu Asn Asp Leu Gln Lys Lys Leu Asn Gln Ile 
    130                 135                 140                 


Gln Ser Ile Lys Asn Ser Leu Glu Lys Asn Lys Ala His Phe Lys Lys 
145                 150                 155                 160 


Glu Ser Ile Asn Asn Thr Thr Asp Arg Val Lys Gly Asn Asn Lys Lys 
                165                 170                 175     


Ser Leu Phe Tyr Glu Tyr Tyr Arg Asn Ser Ser Lys His Gln Glu Tyr 
            180                 185                 190         


Val Asn Asn Ile Phe Glu Ala Phe Asp Lys Leu Tyr Ser Asn Ser His 
        195                 200                 205             


Glu Asp Ile Asn Asn Leu Phe Leu Glu Ile Thr Lys Asp Ser Asn Asn 
    210                 215                 220                 


Arg Asn Ile Arg Lys Ile Arg Glu Val Tyr Asn Glu Ile Leu Asn Lys 
225                 230                 235                 240 


Asn Lys Thr Glu Phe Gly Glu Glu Leu Tyr Lys Lys Ile Gln Asp Asn 
                245                 250                 255     


Ile Ser Asn Phe Asp Lys Leu Leu Glu Ile Glu Pro Glu Ile Lys Glu 
            260                 265                 270         


Leu Thr Lys Ser Gln Ile Phe Tyr Lys Tyr Tyr Ile Asp Lys Val Ser 
        275                 280                 285             


Leu Asp Gly Thr Asn Ile Lys His Cys Phe Ser His Leu Val Glu Ile 
    290                 295                 300                 


Glu Val Asn Gln Leu Leu Lys Asn Tyr Val Tyr Ser Lys Arg Ser Thr 
305                 310                 315                 320 


Asn Lys Glu Lys Leu Glu Asn Ile Phe Glu Tyr Cys Lys Leu Arg Asn 
                325                 330                 335     


Leu Val Lys Asn Lys Leu Val Asn Lys Leu Asn Asn Tyr Ile Arg Asn 
            340                 345                 350         


Cys Gly Lys Tyr Asn Ser Tyr Ile Asn Asn Asn Asp Val Val Asn Ser 
        355                 360                 365             


Glu Lys Ile Ser Glu Ile Arg Thr Lys Glu Ala Phe Leu Arg Ser Ile 
    370                 375                 380                 


Ile Gly Val Ser Ser Ser Ala Tyr Phe Ser Leu Arg Asn Ile Leu Asn 
385                 390                 395                 400 


Thr Asp Asn Thr Gln Asp Ile Thr Asn Lys Val Lys Gly Glu Val Glu 
                405                 410                 415     


Lys Leu Tyr Gln Glu Asn Lys Lys Val Lys Leu Glu Glu Arg Leu Lys 
            420                 425                 430         


Leu Phe Phe Gly Asn Asn Phe Asp Ile Asn Asn Gln Gln Glu Ile Glu 
        435                 440                 445             


Asp Phe Leu Met Asn Ile Asp Lys Ile Ile Ser Asn Ile Arg His Glu 
    450                 455                 460                 


Ile Ile His Phe Lys Ile Glu Ala Asn Ala His Ser Ile Phe Asp Phe 
465                 470                 475                 480 


Asn Asn Val Thr Leu Gly Asn Lys Ala Lys Asn Ile Phe Asn Asn Glu 
                485                 490                 495     


Ile Asn Glu Glu Arg Ile Lys Phe Lys Ile Phe Lys Gln Leu Asn Ser 
            500                 505                 510         


Ala Asn Val Phe Asp Tyr Leu Ser Asp Glu Asn Ile Thr Glu Tyr Met 
        515                 520                 525             


Gly Lys Val Ile Phe Ser Phe Thr Asn Arg Asn Ile Pro Phe Val Pro 
    530                 535                 540                 


Ser Phe Arg Lys Ile Tyr Asn Arg Val Gln Asp Leu Ala Asn Ser Leu 
545                 550                 555                 560 


Lys Ile Lys Glu Trp Lys Ile Ser Asp Glu Ser Glu Gly Lys Asp Ala 
                565                 570                 575     


Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asp Asp 
            580                 585                 590         


Phe Leu Asn Glu Lys Asn Glu Lys Phe Ile Lys Ile Lys Asp Glu Ile 
        595                 600                 605             


Ile Glu Leu Asn Lys Asn Gln Asn Lys Ile Thr Gly Phe Tyr Lys Leu 
    610                 615                 620                 


Glu Lys Phe Glu Lys Ile Glu Glu Lys Asn Pro Lys Lys Tyr Leu Glu 
625                 630                 635                 640 


Ile Ile Gln Ser Leu Tyr Met Ile Asn Ile Glu Glu Ile Asp Asn Glu 
                645                 650                 655     


Glu Lys Asn Ile Phe Leu Asp Phe Ile Gln Lys Ile Phe Leu Lys Gly 
            660                 665                 670         


Phe Phe Glu Phe Ile Lys Asn Asn Tyr Asn Tyr Leu Leu Glu Leu Lys 
        675                 680                 685             


Lys Ile Gln Asp Lys Lys Asn Ile Phe Asp Arg Glu Met Ser Glu Tyr 
    690                 695                 700                 


Ile Ala Gly Glu Lys Thr Leu Glu Asp Ile Gly Glu Ile Asn Glu Ile 
705                 710                 715                 720 


Ile Gln Lys Ile Glu Ile Thr Lys Ile Asp Lys Ile Leu Asn Leu Thr 
                725                 730                 735     


Asp Lys Ile Asn Cys Phe Tyr Leu Leu Leu Lys Leu Leu Asn Tyr Lys 
            740                 745                 750         


Glu Ile Thr Glu Leu Lys Gly Asn Leu Glu Lys Tyr Gln Ile Leu Ser 
        755                 760                 765             


Lys Thr Asp Ile Tyr Glu Lys Glu Leu Ile Leu Leu Asn Ile Val Asn 
    770                 775                 780                 


Leu Asp Asn Asn Lys Val Lys Ile Glu Lys Phe Lys Ile Ser Ala Glu 
785                 790                 795                 800 


Glu Ile Gly Lys Phe Ile Glu Lys Ile Ser Arg Asn Lys Lys Ile Lys 
                805                 810                 815     


Thr Phe Glu Glu Leu Arg Asn Phe Glu Lys Arg Glu Asn Thr Gly Glu 
            820                 825                 830         


Tyr Tyr Asn Val Tyr Ser Asp Asp Lys Asn Ile Lys Asn Ile Arg Asn 
        835                 840                 845             


Leu Tyr Asn Ile Lys Lys Tyr Gly Met Leu Asp Leu Leu Glu Arg Ile 
    850                 855                 860                 


Ser Glu Lys Ser Asn Tyr Cys Ile Lys Lys Glu Asp Leu Lys Glu Tyr 
865                 870                 875                 880 


Asp Lys Leu Lys Lys Lys Leu Glu Asp Lys Lys Thr Asp Phe Tyr Lys 
                885                 890                 895     


Ile Gln Lys Asp Leu His Tyr Lys Tyr Gln Lys Glu Tyr Lys Asn Phe 
            900                 905                 910         


Ser Lys Lys Asn Asn Thr Glu Asp Tyr Glu Lys Tyr Lys Glu Ser Ile 
        915                 920                 925             


Glu Asn Ile Glu Lys Tyr Val His Leu Lys Asn Lys Ile Glu Phe Asn 
    930                 935                 940                 


Glu Leu Asn Leu Leu Gln Ser Leu Leu Leu Lys Ile Leu His Arg Leu 
945                 950                 955                 960 


Val Gly Phe Thr Ser Ile Trp Glu Arg Asp Leu Arg Phe Arg Leu Ile 
                965                 970                 975     


Gly Glu Phe Pro Asp Glu Leu Asp Val Glu Asp Ile Phe Asp His Arg 
            980                 985                 990         


Glu Arg Tyr Arg Gly Thr Arg Gly  Gln Ile Cys Lys Lys  Tyr Asp Gln 
        995                 1000                 1005             


Phe Ile  Ser Val His Ile Glu  Tyr Gln Asn Asn Lys  Lys Met Lys 
    1010                 1015                 1020             


Asn Ile  Lys Phe Asp Asp Asn  Asn Pro Ile Arg Asn  Tyr Ile Ala 
    1025                 1030                 1035             


His Phe  Asn Tyr Leu Pro Thr  Pro Lys Tyr Ser Ile  Leu Lys Met 
    1040                 1045                 1050             


Leu Gly  Lys Leu Arg Glu Leu  Leu Asp Tyr Asp Arg  Lys Leu Lys 
    1055                 1060                 1065             


Asn Ala  Val Met Lys Ser Ile  Lys Asp Ile Leu Glu  Glu Tyr Gly 
    1070                 1075                 1080             


Phe Lys  Ala Glu Phe Val Ile  Asn Pro Asp Lys Glu  Ile Ile Leu 
    1085                 1090                 1095             


Asn Ser  Val Lys Ser Val Glu  Ile Ile His Leu Lys  Lys Asn Asp 
    1100                 1105                 1110             


Leu Asn  Ser His Arg Asn Ser  Glu Asp Leu Cys Lys  Leu Val Lys 
    1115                 1120                 1125             


Ala Met  Leu Glu Tyr Ser Glu  
    1130                 1135 


<210>  1230
<211>  1412
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1230

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Thr Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Lys Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Lys Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Glu 
        755                 760                 765             


Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Arg Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Lys Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1100                 1105                 1110             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1115                 1120                 1125             


Asn Asp  Ser Lys Lys Pro Glu  Gly Tyr Lys Asn Ile  Lys Val Asp 
    1130                 1135                 1140             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1145                 1150                 1155             


Tyr Ile  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Gly Asp 
    1160                 1165                 1170             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1175                 1180                 1185             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1190                 1195                 1200             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1205                 1210                 1215             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1220                 1225                 1230             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1235                 1240                 1245             


Val Phe  Asp Arg Phe Phe Thr  Tyr Asp Ile Arg Tyr  Gln Lys Asn 
    1250                 1255                 1260             


Val Leu  Asn Leu Leu Gln Asn  Ile Leu Leu Arg His  Asn Val Ile 
    1265                 1270                 1275             


Val Glu  Pro Ile Leu Glu Ser  Gly Phe Lys Thr Ile  Gly Glu Gln 
    1280                 1285                 1290             


Thr Lys  Pro Gly Ala Lys Leu  Ser Ile Arg Ser Ile  Lys Ser Asp 
    1295                 1300                 1305             


Thr Phe  Gln Tyr Lys Val Lys  Gly Gly Thr Leu Ile  Thr Asp Ala 
    1310                 1315                 1320             


Lys Asp  Glu Arg Tyr Leu Glu  Thr Ile Arg Lys Ile  Leu Tyr Tyr 
    1325                 1330                 1335             


Ala Glu  Asn Glu Glu Asp Asn  Leu Lys Lys Ser Val  Val Val Thr 
    1340                 1345                 1350             


Asn Ala  Asp Lys Tyr Glu Lys  Asn Lys Glu Ser Asp  Asp Gln Asn 
    1355                 1360                 1365             


Lys Gln  Lys Glu Lys Lys Asn  Lys Asp Asn Lys Gly  Lys Lys Asn 
    1370                 1375                 1380             


Glu Glu  Thr Lys Ser Asp Ala  Glu Lys Asn Asn Asn  Glu Arg Leu 
    1385                 1390                 1395             


Ser Tyr  Asn Pro Phe Ala Asn  Leu Asn Phe Lys Leu  Ser Asn 
    1400                 1405                 1410         


<210>  1231
<211>  1284
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1231

Met Ile Ile Gly Gly Ile Asn Met Lys Leu Thr Arg Arg Arg Ile Ser 
1               5                   10                  15      


Gln Glu Arg Lys Asn Gln Lys Leu Thr Ala Ala Phe Tyr Arg Asp Met 
            20                  25                  30          


Asp His Gly Leu Leu Tyr Val Asp Ser Glu Asp Glu Asp Arg Thr Glu 
        35                  40                  45              


Tyr Val Val Ser Ser Met Asp Phe Glu Arg Ser Trp Arg Gly Arg Ile 
    50                  55                  60                  


Leu Lys Asn Gly Glu Asp Asn Lys Asn Pro Phe Tyr Glu Phe Val Lys 
65                  70                  75                  80  


Gly Leu Val Gly Ser Asn Glu Ile Ile Cys Lys Pro Ile Thr Asn Asp 
                85                  90                  95      


Asn Asn Thr Asp Ile Asn Glu Lys Ile Lys Lys Tyr Ile Thr Glu Phe 
            100                 105                 110         


Gly Arg Asn Leu Lys Ala Pro Gly Ser Glu Val Thr Leu Glu Lys Leu 
        115                 120                 125             


Ile Leu Asn Ile Gln Ser Gly Thr Ser Glu Asn Glu Val Arg Pro Glu 
    130                 135                 140                 


Leu Glu Lys Ile Lys Asp Met Ile Lys Lys Asp Ile Glu Lys Arg Lys 
145                 150                 155                 160 


Asp Glu Leu Ile Lys Ser Ile Thr Asn Asn His Ile Pro Phe Met Leu 
                165                 170                 175     


Asp Glu Asp Lys Leu Val Pro Ser Thr Lys Lys Met Lys Trp Leu Tyr 
            180                 185                 190         


Lys Phe Leu Asn Gly Pro Asp Lys Ser Leu Asn Leu Gln Met Phe Asp 
        195                 200                 205             


Glu Tyr Trp Thr Lys Tyr Gly Tyr Lys Asn Leu Glu Glu Lys Ile Ile 
    210                 215                 220                 


Lys Glu Ile Asn Ser Leu Pro Glu Lys Asn Ala Arg Ser Ile Ser Arg 
225                 230                 235                 240 


Ala Val Ser Lys Thr Val Arg Glu Tyr Asn Arg Asn Phe Arg Ile Asn 
                245                 250                 255     


Tyr Met Val Pro Glu Asn Glu Asn Ala Glu Ala Asp Ser Asp Tyr Glu 
            260                 265                 270         


Gly Phe Leu Leu Phe Leu Lys Ala Val Glu Gln His Phe Lys Lys Tyr 
        275                 280                 285             


Tyr Pro Val Lys Ser Lys Asp Ser Ser Glu Val Arg Asp Lys Asn Leu 
    290                 295                 300                 


Cys Glu Glu Lys Asn Tyr Lys Phe Tyr Cys Ser Tyr Asn Phe Val Lys 
305                 310                 315                 320 


Asn Glu Val Lys Arg Ser Ile Ile Asn Gln Leu Val Ser Gly Leu Ile 
                325                 330                 335     


Gln Gln Gly Lys Leu Leu His Tyr Phe Tyr Lys Asp Gly Ile Trp Gln 
            340                 345                 350         


Gln Asp Phe Leu Asn Ser Tyr Gly Leu Ser Tyr Ile Gln Val Glu Glu 
        355                 360                 365             


Ser Phe Lys Lys Ser Leu Met Thr Ser Leu Ser Trp Gly Ile Asn Arg 
    370                 375                 380                 


Leu Thr Ser Phe Phe Ile Asp Val Gly Thr Asp Glu Asn Glu Glu Lys 
385                 390                 395                 400 


Thr Val Gln Asn Lys Lys Gln Lys Asn Asn Arg Lys Ile Asp Asp Ile 
                405                 410                 415     


Leu Ser Asp Lys Ser Asn Leu Arg Ala Ile Phe Asn Asp Leu Arg Ser 
            420                 425                 430         


Asn Thr Glu Leu Gln Lys His Phe Lys Glu Lys Leu Ala Phe Cys Tyr 
        435                 440                 445             


Pro Ile Phe Ile Lys Val Lys Lys Glu Lys Met Phe Asp Asp Ile Glu 
    450                 455                 460                 


Lys Leu Ile Lys Leu Val Glu Glu Ala Arg Glu Ser Val Ala Tyr Leu 
465                 470                 475                 480 


Arg His Arg Cys Phe His Tyr Lys Asp Val Thr Ile Thr Glu Met Leu 
                485                 490                 495     


Lys Ala Leu Asn Asn Asn Thr Glu Thr Asp Lys Thr Glu Asp Ile Asp 
            500                 505                 510         


Tyr Ser Val Ala Ala Glu Tyr Phe Leu Arg Asp Ile Asn Asn Leu Tyr 
        515                 520                 525             


Asp Ala Phe Arg Glu Gln Ile Arg Ser Ser Gly Ile Ala Asp Tyr Tyr 
    530                 535                 540                 


Pro Ala Asp Ile Ile Ser Gly Cys Phe Lys Lys Cys Gly Leu Gln Phe 
545                 550                 555                 560 


Val Leu Tyr Ser Pro Gln Asn Ser Leu Met Pro Ser Phe Lys Asn Ile 
                565                 570                 575     


Tyr Lys Arg Gly Ser Asn Leu Tyr Lys Ala Tyr Gln Glu Glu Lys Glu 
            580                 585                 590         


Gln Lys Asp Lys Glu Tyr Lys Arg His Asn Thr Asn Ile Val Gln Glu 
        595                 600                 605             


Glu Ser Lys Glu Leu Ser Trp Tyr Ile Glu Val Ser Asp Thr Glu Gln 
    610                 615                 620                 


Gly Lys Thr Ala Tyr Arg Asn Leu Leu Gln Leu Ile Tyr Tyr His Ala 
625                 630                 635                 640 


Phe Leu Pro Glu Val Arg Glu Asn Glu Ser Leu Ile Thr Val Tyr Phe 
                645                 650                 655     


Ala Lys Thr Lys Glu Trp Asn Arg Lys Val Ala Glu Thr Lys Ala Lys 
            660                 665                 670         


Lys Lys Asn Ala Gly Lys Thr Tyr Lys Asp Lys Pro Ile Arg Ala Tyr 
        675                 680                 685             


Arg Tyr Glu Ala Ile Pro Asp Tyr Val Gly Glu Arg Leu Asp Asp Tyr 
    690                 695                 700                 


Phe Lys Ile Leu Gln Arg Glu Gln Met Ala Lys Ala Lys Asp Val Asn 
705                 710                 715                 720 


Glu Gly Asn Ala Glu Asn Asn Asn Tyr Ile Gln Phe Ile Arg Asp Val 
                725                 730                 735     


Val Val Trp Ala Phe Gly Ala Tyr Leu Glu Glu Arg Leu Glu Lys Tyr 
            740                 745                 750         


Lys Lys Asp Leu Gln Ser Ser His Ser Gln Lys Asp Lys Lys Asp Val 
        755                 760                 765             


Asn Asp Ala Leu Lys Glu Leu Phe Pro Asp Asp Lys Asp Lys Arg Gln 
    770                 775                 780                 


Phe Phe Met Lys Cys Lys Phe Thr Asp Val Leu Ile Asn Asp Val Gly 
785                 790                 795                 800 


Glu Asn Asn Gln Ile Thr Glu Met Glu Asp Leu Glu Thr Ser Lys Glu 
                805                 810                 815     


Gln Gln Asn Arg Glu Ile Lys Arg Lys Asp Leu Leu Cys Phe Tyr Leu 
            820                 825                 830         


Phe Leu Arg Leu Leu Asp Glu Arg Glu Ile Ser Gly Leu Lys His Gln 
        835                 840                 845             


Phe Val Arg Tyr Arg Cys Ser Leu Lys Glu Arg Arg Leu Pro Asp Asn 
    850                 855                 860                 


Arg Lys Asp Val Asp Glu Glu Ile Val Leu Leu Glu Glu Leu Glu Glu 
865                 870                 875                 880 


Leu Met Glu Leu Val Ser Tyr Thr Met Pro Ser Val Pro Glu Leu Ser 
                885                 890                 895     


Gly Lys Ala Glu Ser Gly Leu Asp Leu Val Ile Ser Lys Tyr Phe Lys 
            900                 905                 910         


Asp Phe Phe Glu Lys Ser Ala Leu Lys Asn Gln Asp Ile Met Lys Leu 
        915                 920                 925             


Tyr Tyr Gln Ser Asp Asn Lys Thr Pro Val Phe Arg Lys Tyr Met Ala 
    930                 935                 940                 


Leu Leu Met Arg Ser Ala Pro Leu Gln Leu Tyr Lys Asp Met Phe Arg 
945                 950                 955                 960 


Asn Tyr Tyr Ile Ile Thr Glu Lys Glu Cys Gln Glu Tyr Ile Lys Thr 
                965                 970                 975     


Ser Gln Asp Ile Asp Ala Phe Gln Cys Lys Leu Asn Glu Leu His Lys 
            980                 985                 990         


Glu Leu Glu His Val Arg Leu Lys  Thr Val Glu Asp Lys  Lys Gly Lys 
        995                 1000                 1005             


Ile Phe  Tyr Tyr Leu Ala Gly  Ser Asp Ala Glu Arg  Val Lys Glu 
    1010                 1015                 1020             


Tyr Glu  Asp Thr Leu Ser Lys  Val Val Arg Tyr Lys  Arg Leu Gln 
    1025                 1030                 1035             


His Lys  Leu Thr Phe Glu Ser  Leu Tyr Thr Ile Phe  Lys Ile His 
    1040                 1045                 1050             


Val Asp  Ile Ala Ala Arg Met  Val Gly Tyr Thr Glu  Asp Trp Glu 
    1055                 1060                 1065             


Arg Asp  Met Leu Phe Leu Phe  Lys Ser Leu Glu Tyr  Asn Glu Lys 
    1070                 1075                 1080             


Leu Asn  Glu Gly Val Val Glu  Lys Ile Phe Asn Asn  Lys Asp Glu 
    1085                 1090                 1095             


Lys Gly  His Ile Val Lys Lys  Leu Lys Asp Asn Leu  Asn Ser Glu 
    1100                 1105                 1110             


Asp Lys  Glu Lys Ile Gly Ile  Leu Cys Trp His Lys  Glu Ile Thr 
    1115                 1120                 1125             


Asp Lys  Asn Phe Val Glu Ile  Ile Trp Ile Arg Asn  Pro Ile Ala 
    1130                 1135                 1140             


His Leu  Asn His Phe Met Gln  Thr Val Lys Asn Pro  Lys Arg Ser 
    1145                 1150                 1155             


Leu Glu  Lys Met Ile Asn Ala  Leu Cys Val Leu Leu  Ser Tyr Asp 
    1160                 1165                 1170             


Arg Lys  Arg Gln Asn Ser Val  Thr Lys Thr Ile Asn  Asp Leu Leu 
    1175                 1180                 1185             


Leu Asn  Glu Tyr His Val Lys  Ile Lys Trp Lys Arg  Trp Val Asp 
    1190                 1195                 1200             


Lys Asn  Cys Asn Ile Tyr Tyr  Tyr Ile Asp Glu Gln  Asn Ile Glu 
    1205                 1210                 1215             


Asn Glu  Pro Ile Leu His Ile  Lys His Leu His Met  Gly Glu Lys 
    1220                 1225                 1230             


Cys His  Val Asn Arg Asn Ala  Asp Met Phe Asp Arg  Gln Lys Glu 
    1235                 1240                 1245             


Trp Leu  Arg Asn Gly Ile Thr  Glu Glu Val Tyr Asp  Lys Ser Met 
    1250                 1255                 1260             


Leu Gly  Cys Ile Cys Arg Leu  Phe Lys Phe Asp Tyr  Asn Asp Leu 
    1265                 1270                 1275             


Tyr Gly  Ala Asn Arg Gln 
    1280                 


<210>  1232
<211>  1256
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1232

Leu Leu Arg Met Lys Arg Glu Lys Asn Ile Thr Ile Met Lys Ile Ser 
1               5                   10                  15      


Lys Val Asn His Arg Arg Thr Ala Val Ala Leu Asn Gly Asp Lys Ser 
            20                  25                  30          


Glu Leu Gly Gly Ile Leu Tyr Glu Ala Pro Val Gln Lys Asp Arg Asn 
        35                  40                  45              


Gly Asn Tyr Asn Asp Val Ile Ala Glu Thr Gly Lys Val Val Asn Glu 
    50                  55                  60                  


Ala Leu Asp Lys Lys Ser Arg Leu Tyr Thr Pro Phe Asn Asn Gln Lys 
65                  70                  75                  80  


Val Ile Ile Asp Lys Asn Leu Gln Arg Tyr Ala Asn Asn Leu Lys Arg 
                85                  90                  95      


Cys Tyr Ile Asn Phe Val Lys Gln Tyr Val Asn Asn Lys Ser Phe Asn 
            100                 105                 110         


Tyr Lys Ala Met Gln Phe Ile Pro Asp Ile Gln Asn Pro Lys Thr Asn 
        115                 120                 125             


Asp Ala Val Asn Tyr Arg Thr Asp Arg Asp Asn Val Tyr Asn Lys Asn 
    130                 135                 140                 


Lys Tyr Tyr Asp Lys Gln Thr Lys Ser Lys Ser Lys Lys Phe Ile Tyr 
145                 150                 155                 160 


Glu Lys Ile Val Ile Pro Gln Asn Glu Gln Asn Ile Val Ile Ser Ala 
                165                 170                 175     


Leu Val Asn Cys Ser Leu Arg Lys Ser Leu Arg Lys Asp Val Ser Tyr 
            180                 185                 190         


Lys Thr Lys Ser Gly Glu Ile Lys Thr Tyr Asn Leu Pro Glu Leu Val 
        195                 200                 205             


Lys Lys Ser Met Arg Phe Tyr Cys Leu Glu Gly Gln Arg Glu Pro Asp 
    210                 215                 220                 


Glu Lys Glu Lys Tyr Glu Met Tyr Ile Leu Phe Ser Tyr Met Lys Glu 
225                 230                 235                 240 


Asp Lys Arg Thr Lys Asn Thr Asp Leu Leu Val Lys Ser Ile Ser Asn 
                245                 250                 255     


Gln Asn Thr Lys Val Lys Val Glu Asp Ile Asp Gly Asn Lys Leu Leu 
            260                 265                 270         


Lys Leu Ser Ile Ala Asp Thr Lys Lys Lys Pro Leu Trp Glu Tyr Leu 
        275                 280                 285             


Ile Lys Tyr Ala Asp Ser Ser Arg Gln Arg Glu Leu Met Tyr Asp Ile 
    290                 295                 300                 


Arg Lys Lys Ile Ile Leu Tyr Val Ala Gly Ile Glu Glu Tyr Glu Asn 
305                 310                 315                 320 


Ile Lys Glu Asp Ser Gly Leu Ser Lys Val Ser Trp Ser Lys Tyr Asn 
                325                 330                 335     


Ile Ser Asp Asn Lys Met Phe Phe Asp Ile Asn Ser Cys Thr Asp Lys 
            340                 345                 350         


Arg Lys Gln Asn Leu Glu Ile Lys Ile Arg Glu Ala Asn Ile Glu His 
        355                 360                 365             


Tyr Arg Asn Ala Ser Ser Lys Leu Cys Asp Asp Glu Ser Ile Phe Trp 
    370                 375                 380                 


Phe Gln His Phe Glu Gly Val Ile Glu Thr Leu Phe Ser Lys Lys Ser 
385                 390                 395                 400 


Lys Ile Ser Glu Glu Arg Leu Gly Cys Ala Tyr Ile Cys Asp Tyr Leu 
                405                 410                 415     


Trp Lys Asp Phe Leu Ser Tyr Leu Ala Ala Lys Tyr Ile Asp Leu Gly 
            420                 425                 430         


Lys Gly Val Tyr His Phe Thr Met Lys Asp Lys Leu Asp Met Leu Asn 
        435                 440                 445             


Lys Asn Glu Ala Val Thr Asp Leu Arg Phe Gly Ile Val Ser Glu Lys 
    450                 455                 460                 


Tyr Glu Lys Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys Ala Glu 
465                 470                 475                 480 


Glu Glu Leu Asp Arg Asn Ile Ala Ala Tyr Val Thr Phe Ala Ala Asp 
                485                 490                 495     


Ile Phe Ala Lys Ser Val Ile Lys Ser Asp Tyr Arg Thr Lys Lys Asp 
            500                 505                 510         


Asn Asn Ser Asp Val Leu Gln Tyr Ser Asp Lys Glu Phe Arg Asn Ser 
        515                 520                 525             


Glu Val Ile Arg Asp Asn Ala Glu Lys Asn Ile Leu Gln Tyr Trp Gly 
    530                 535                 540                 


Gly Tyr Ser Arg Trp Gly Thr Glu Asn Ser Lys Leu Pro Glu Asn Asn 
545                 550                 555                 560 


Lys Val Ser Asp Phe Gly Lys Leu Asp Val Ser Asp Leu Cys Ile Asp 
                565                 570                 575     


Ile Lys Lys His Leu Ala Gly Ile Arg Asn Ser Ser Val His Tyr Thr 
            580                 585                 590         


Thr Lys Ile Lys Asn Glu Ser Ala Ala Asp Gly Ser Asn Val Lys Ile 
        595                 600                 605             


Leu Phe Glu Lys Asp Leu Ala Asp Ile Asn Ile Ile Tyr Ala Asp Lys 
    610                 615                 620                 


Tyr Tyr Ser Asn Asn Val Trp Met Phe Tyr Ser Leu Glu Asp Ile Asn 
625                 630                 635                 640 


Lys Leu Ile Ala Phe Leu Tyr Lys Glu Lys Arg Val Ile Arg Gln Val 
                645                 650                 655     


Gln Ile Pro Ser Phe Ser Arg Ile Leu Lys Arg Lys Ala Met Gln Asp 
            660                 665                 670         


Val Ile Asn Glu Ile Phe Lys Asp Asp Phe Asp Glu Asn Ile Val Asn 
        675                 680                 685             


Pro Glu Leu Lys Glu Lys Tyr Arg Asn Ser Leu Tyr Phe Met Leu Lys 
    690                 695                 700                 


Glu Ile Tyr Tyr Asn Ala Phe Ile Ile Gln Pro Glu Leu Lys Glu Lys 
705                 710                 715                 720 


Phe Lys Asp Lys Ile Lys Ile Met Lys Ser Glu Leu Tyr Asn Lys Leu 
                725                 730                 735     


Lys Thr Ile Asp Lys Lys Glu Tyr Lys Ala Leu Tyr Cys Met Leu Ser 
            740                 745                 750         


Asn Glu Glu Ser Ala Leu Lys Asn Phe Ala Asp Arg Ile Tyr Ser Val 
        755                 760                 765             


Asp Gly Asp Asn Val Ser Phe Ala Asp Ile Cys Lys Ile Leu Met Thr 
    770                 775                 780                 


Asp Tyr Asn Met Gln Asn Gln Glu Lys Lys Asn Ile Glu Ser Met Glu 
785                 790                 795                 800 


Gln Lys Lys Lys Asn Lys Gly Lys Asp Glu Asn Tyr Lys His Phe Pro 
                805                 810                 815     


Leu Leu Leu His Lys Val Leu Lys Glu Leu Phe Ile Glu Tyr Leu Lys 
            820                 825                 830         


Gln Thr His Glu Leu Glu Phe Leu Arg Asn Asn Ile Cys Ile Lys Ser 
        835                 840                 845             


Asp Val Thr Met Glu Ser Phe Glu Ser Gln Ile Lys Gly Val Glu Ile 
    850                 855                 860                 


Tyr Lys Asp Leu Lys Glu Lys Ile Asp Lys Asn Asn Ser Leu Leu Asp 
865                 870                 875                 880 


Trp Tyr Val Ile Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu 
                885                 890                 895     


Ile Gly Asn Ile Lys Asn Tyr Ile Gln Phe Ala Thr Asn Ile Asp Lys 
            900                 905                 910         


Arg Ala Glu Ser Val Lys Asn Leu Thr Glu Ser Gly Met Val Lys Arg 
        915                 920                 925             


Ile Gln Tyr Tyr Asp Asp Ile Val Arg Thr Leu Glu Phe Ser Ala Gln 
    930                 935                 940                 


Tyr Ile Gly Lys Ile Ser Asn Asn Ile Asn Asp Tyr Phe Asn Ser Glu 
945                 950                 955                 960 


Asp Glu Tyr Val Ser Phe Leu Ser Lys Tyr Val Gly Phe Ile Asn Asp 
                965                 970                 975     


Lys Ser Glu Asp Val Leu Thr Glu Leu Lys Asp Phe Cys Arg Glu Lys 
            980                 985                 990         


Ile Asn Asn Gly Ser Gln Ile Ile  Gly Ile Tyr Tyr Gly  Gly Asp Asn 
        995                 1000                 1005             


Val Ile  Ile Asn Arg Asn Val  Ile Tyr Ala Gln Met  Tyr Ser Asn 
    1010                 1015                 1020             


Ala Glu  Val Phe Ser Asn Ile  Tyr Lys Lys Val Thr  Lys Asn Asp 
    1025                 1030                 1035             


Ile Ile  Asn Tyr Tyr Glu Lys  Gln Asn Asp Leu Lys  Asp Val Phe 
    1040                 1045                 1050             


Lys Ser  Gly Val Cys Gln Asn  Glu Gly Glu Gln Arg  Ser Leu Cys 
    1055                 1060                 1065             


Glu Phe  Gln Gln Leu Lys Asn  Arg Ile Glu Leu Thr  Glu Leu Ser 
    1070                 1075                 1080             


Thr Tyr  Ala Asp Met Val Asn  Asp Phe Met Ala Gln  Phe Val Glu 
    1085                 1090                 1095             


Trp Ala  Tyr Leu Arg Glu Arg  Asp Leu Met Tyr Phe  Gln Leu Gly 
    1100                 1105                 1110             


Ile His  Tyr Ile Arg Leu Phe  Tyr Ser Asp Asn Val  Leu Asp Glu 
    1115                 1120                 1125             


Lys Tyr  His Lys Leu Ser Asp  Asn Val Ile Asp Ile  Glu Glu Gly 
    1130                 1135                 1140             


Ala Leu  Leu Tyr Gln Ile Val  Ala Met Tyr Asp Tyr  Glu Leu Arg 
    1145                 1150                 1155             


Ile Phe  Glu Thr Asp Asn Ser  Gly Asn Ala Lys Arg  Ile Gly Gln 
    1160                 1165                 1170             


Gly Gly  Pro Gly Lys Ser Ile  Pro Val Phe Leu Lys  Lys Tyr Cys 
    1175                 1180                 1185             


Asn Gly  Thr Asp Val Tyr Glu  Cys Gly Leu Glu Leu  Phe Glu Asp 
    1190                 1195                 1200             


Ile Asn  Gln His Glu His Ile  Ile Arg Phe Arg Asn  Asp Ile Ala 
    1205                 1210                 1215             


His Met  Arg Tyr Met Ser Asn  Gln Ala Met Asn Ile  Met Ser Ile 
    1220                 1225                 1230             


Val Ser  Asn Ile Tyr Lys Ser  Phe Phe Val Tyr Asp  Thr Lys Leu 
    1235                 1240                 1245             


Lys Lys  Ser Ile Ser Leu Val  Phe 
    1250                 1255     


<210>  1233
<211>  1170
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1233

Met Lys Ile Thr Lys Asn Thr Lys Asn Gly Lys Leu Glu Phe Tyr Arg 
1               5                   10                  15      


Asp Val Lys Glu Gly Gly Leu Arg Asp Pro Lys Ser Lys Thr Ile Trp 
            20                  25                  30          


Thr Ser Glu Thr Ile Lys Arg Met Asp Ile Asn Lys Ser Leu Lys Gly 
        35                  40                  45              


Arg Ile Leu Ala Tyr Gly Thr Ser Leu Gly Ser Ser Asn Pro Tyr Ser 
    50                  55                  60                  


Val Phe Val Asp Ser Leu Ile Arg Glu Asn Lys Glu Ile Ser Leu Ser 
65                  70                  75                  80  


Glu Leu Lys Arg Glu Gln Cys Lys Lys Glu Asn Val Gln Lys Tyr Leu 
                85                  90                  95      


Ser Ala Tyr Gly Arg Met Ile Asn His Gly Ala Glu Glu Asn Thr Ser 
            100                 105                 110         


Leu Gly Asn Leu Leu Val Glu Tyr Gly Asn Gly Ala Glu Ile Ser Glu 
        115                 120                 125             


Ala Leu Val Gln Ile Lys Lys Gln Ile Leu Lys Leu Lys Arg His Lys 
    130                 135                 140                 


Lys Lys Ser Leu Leu Asp Ser Phe Met Asn Asn Lys Ile Pro Phe Lys 
145                 150                 155                 160 


Leu Thr Asp Gly Lys Leu Glu Pro Ala Thr Asp Lys Met Ser Arg Leu 
                165                 170                 175     


Phe Ser Leu Leu Glu Glu Asp Gly Val Asp Lys Asn Lys Phe Glu Lys 
            180                 185                 190         


Tyr Lys Thr Trp Tyr Gln Tyr Glu Val Leu Lys Glu Arg Leu Asp Leu 
        195                 200                 205             


Ile Cys Glu Glu His Phe Ser Ala Ala Glu Arg Lys Pro Arg Val Leu 
    210                 215                 220                 


Ala Lys Lys Ile Tyr Ser Ala Val Lys Leu Tyr Asn Lys Glu Lys Ala 
225                 230                 235                 240 


Asn Ser Asp Val Ile Lys Asn Lys Asp Asp Ala Tyr Ser Leu Phe Leu 
                245                 250                 255     


Asp Glu Ile Arg Asp His Phe Arg Lys Tyr Phe Pro Val Thr Gly Lys 
            260                 265                 270         


Lys Gly Leu Ser Ser Gly Gly Asp Ser Glu Lys Leu Asn Ser Leu Ala 
        275                 280                 285             


Ser Glu Lys Asn Val Lys Tyr Tyr Tyr Ser Asp Lys Tyr Val Phe Gln 
    290                 295                 300                 


Gln Val Trp Arg Gln Ile Val Asn Gln Leu Thr Ala Gly Leu Ile Gln 
305                 310                 315                 320 


Tyr Gly Lys Leu Ser Tyr Tyr Phe His Asp Lys Glu Asn His Thr Trp 
                325                 330                 335     


Gln Glu Glu Lys Leu Asn Ser Ala Gly Met Gln Glu Ile Gln Val Arg 
            340                 345                 350         


Glu Thr Phe Lys Lys Gln Leu Phe Leu Ser Val Val Trp Ser Val Asn 
        355                 360                 365             


Lys Leu Asn Tyr Phe Phe Gln Tyr Gly Gly Glu Asn Pro Lys Met Leu 
    370                 375                 380                 


Tyr Gln Val Lys Tyr Asp Glu Asp Cys Ile Ala Gly Asp Ile Ile Glu 
385                 390                 395                 400 


Glu Leu Arg Lys Ala Asp Phe Ser Arg Phe Cys Tyr Asp Asp Pro Ile 
                405                 410                 415     


Lys Asn Asn Tyr Ile His Arg Phe Met His Gly Ile Lys Glu Glu Pro 
            420                 425                 430         


Glu Lys Phe Glu Leu Leu Phe Asp Lys Met Ser Val Ser Tyr Pro Leu 
        435                 440                 445             


Glu Glu Glu Asp Lys Asn Pro Glu Glu Ile Leu Lys Val Leu Gln Glu 
    450                 455                 460                 


Ile Asn Cys Ser Val Thr Asp Leu Arg His Ser Thr Ile His Tyr Gln 
465                 470                 475                 480 


Lys Asp Val Val Tyr Gln Glu Thr Gln Gly Pro Lys Tyr Pro Lys Ala 
                485                 490                 495     


Ser Glu Phe Leu Arg Arg Asp Ile Asp Asn Ile Glu Asn Cys Phe Leu 
            500                 505                 510         


Glu Gln Ile Arg Ser Met Ser Leu Ala Glu Tyr Tyr Pro Leu Asp Leu 
        515                 520                 525             


Leu Gln Lys Val Phe Lys Asp Cys Asn Leu Asn Phe Gln Leu Tyr Ala 
    530                 535                 540                 


Ser Gln Val Pro Met Val Pro Ser Phe Gln Lys Val Phe Gly Lys Gly 
545                 550                 555                 560 


Val Asn Leu Tyr Lys Ala Asp Gln Lys Ser Asp Ser Leu Lys Trp Tyr 
                565                 570                 575     


Met Glu Val Arg Lys Asp Pro Glu Ala Lys Leu Ala Thr Leu Ala Tyr 
            580                 585                 590         


Arg Asn Phe Ile Gln Leu Ile Tyr Tyr His Gly Phe Leu Pro Ala Val 
        595                 600                 605             


Glu Lys Asn Asn Ala Leu Val Thr Asp Phe Ile Asn Glu Thr Val Glu 
    610                 615                 620                 


Trp Asn Gln Glu Arg Ser Leu Gln Arg Gln Arg Glu Asp Pro Lys Thr 
625                 630                 635                 640 


Lys Gln Ile Asn Phe Ser Lys Tyr Arg Tyr Gln Gly Met Pro Glu Phe 
                645                 650                 655     


Gln Asn Lys Ser Leu Leu Glu Tyr Met Ser Glu Leu Gln Arg Asp Gln 
            660                 665                 670         


Ser Asn Lys Glu Lys Glu Asp Ser Gln Ala Asp Val Pro Glu Asp Lys 
        675                 680                 685             


Lys Lys Arg Tyr Tyr Thr Lys Phe Ile Gln Asp Ile Phe Ala Phe Ser 
    690                 695                 700                 


Phe Gly Ser Phe Leu Asn Ser Lys Leu Asn Glu Cys Arg Glu Asp Leu 
705                 710                 715                 720 


Leu Gln Pro Arg Tyr Gln Glu Met Lys Thr Asn Glu Asp Arg Glu Gln 
                725                 730                 735     


Arg Leu Lys Lys Leu Leu Glu Asp Leu Glu Met Lys Thr Asn Ile Lys 
            740                 745                 750         


Asn Gly Ser Pro Thr Gln Leu Ala Met Tyr Pro Phe Leu Lys Leu Leu 
        755                 760                 765             


Asp Gln Arg Gly Leu Asn Gln Leu Leu His Gln Phe Ile Arg Tyr Ser 
    770                 775                 780                 


Ala Ser Val Lys Asn Ser Phe Met Gln Asp Asp Lys Ala Leu Asn Leu 
785                 790                 795                 800 


Asn Arg Glu Ile Glu Glu Leu Ile Ala Leu Val Ala Phe Thr Lys Arg 
                805                 810                 815     


Pro Leu Met Asn Thr Glu Ala Tyr Ser Lys Ala Ile Glu Met Leu Ser 
            820                 825                 830         


Glu Thr Phe Ile Glu Gly Glu Ile Lys Asp Tyr Ala Asp Leu Tyr Tyr 
        835                 840                 845             


Gln Ser Asp Gln Glu His Ser Val Leu His Arg Asn Ile Ala Tyr Met 
    850                 855                 860                 


Gly Gly Thr Gly Val Ile Ala Leu Tyr Ser Asp Val Leu Arg Asp Cys 
865                 870                 875                 880 


Tyr Arg Val Lys Lys Thr Asp Tyr Val Glu Tyr Lys Lys Ala Asn Ser 
                885                 890                 895     


Lys Glu Asn Gly Arg Gln Phe Thr Arg Ile Gly Glu Asp Gln Lys Arg 
            900                 905                 910         


Leu Gln Asp Leu His Glu Ser Leu Ile Gly Arg Tyr Asn Ser Gly Gln 
        915                 920                 925             


Ile Gln Glu Tyr Lys Lys Leu Leu Arg Lys Thr His Glu Tyr Asn Val 
    930                 935                 940                 


Leu Lys Lys Arg Ile Thr Phe Glu Asn Met Tyr Glu Ile Tyr Gln Leu 
945                 950                 955                 960 


His Thr Glu Leu Leu Gly Arg Leu Ala Ser Phe Ala Glu Asp Trp Glu 
                965                 970                 975     


Arg Asp Met Leu Phe Leu Leu Thr Gly Leu Glu Ser Arg Gly Leu Ile 
            980                 985                 990         


Glu Asp Arg Val Glu Lys Ile Phe  Leu Lys Asp Lys Gly  Gly Val Val 
        995                 1000                 1005             


Ala Lys  Met Asn Lys Asn Leu  Lys Asp Asn Glu Lys  Leu Leu Lys 
    1010                 1015                 1020             


Ser Leu  Tyr Cys Arg Glu Asp  Gln Glu Ser Thr Asp  Phe Trp Lys 
    1025                 1030                 1035             


Thr Phe  His Val Arg Asn Ala  Val Ala His Phe Asn  His Phe Thr 
    1040                 1045                 1050             


Gln Lys  Ser Gln Ser Lys Gly  Gly Ser Val Val Tyr  Gln Arg Ser 
    1055                 1060                 1065             


Ile Glu  Glu Leu Ile Asn Arg  Ile Arg Gly Leu Leu  Ala Tyr Asp 
    1070                 1075                 1080             


Met Lys  Arg Gln Asn Ala Val  Thr Gln Ala Val Gln  Lys Ile Phe 
    1085                 1090                 1095             


Asp Lys  His Gln Met Ile Ile  Lys Phe Lys Pro Val  Thr Ile Asn 
    1100                 1105                 1110             


Ser Asp  Pro Glu Lys Trp Val  Gly Thr Trp Asn Ile  Glu Phe Gly 
    1115                 1120                 1125             


Ile Asp  Cys Ile Arg Ser Lys  Asn Ile Val His Phe  Lys Asn Leu 
    1130                 1135                 1140             


Ser Asp  Arg Ile Cys Leu Ile  Glu Ala His Asp Arg  Asn Thr Ile 
    1145                 1150                 1155             


Lys Ala  Ile Glu Lys Leu Met  Lys Phe Lys Tyr Asn  
    1160                 1165                 1170 


<210>  1234
<211>  949
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1234

Met Pro His Gln Lys Lys Met Ala Glu Arg Ile Lys Phe Val Asn Tyr 
1               5                   10                  15      


Gly Tyr Tyr Leu Arg Leu Lys Lys Asn Cys Ala Asp Ser Phe Glu Tyr 
            20                  25                  30          


Tyr Trp Cys Asp Tyr Ile Lys Glu Phe Ile Glu Glu Asn Tyr Val Thr 
        35                  40                  45              


Lys Ile Lys Glu Ala Lys Gly Lys Asn Gly Arg Gln Leu Thr Glu Glu 
    50                  55                  60                  


Asn Cys Asn Ser Glu Ala Met Leu Ser Lys Cys Trp His Asp Met Ile 
65                  70                  75                  80  


Arg His Met Cys Ala Lys Tyr Met Asp Leu Gly Lys Ala Val Tyr His 
                85                  90                  95      


Phe Met Leu Pro Gly Lys Ala Glu Gly Asn Asp Leu Cys Leu Asp Arg 
            100                 105                 110         


Leu Asn Asp Ser Phe Ser Lys Gly Ile Thr Ser Phe Asp Tyr Glu Asn 
        115                 120                 125             


Ile Lys Ala Glu Glu Asn Leu Gln Lys Ala Met Phe Gly Val Leu Val 
    130                 135                 140                 


Ser Gly Thr Phe Asn Phe Ser Arg Ser Val Ala Asp Tyr Ser Gly Pro 
145                 150                 155                 160 


Ala Ala Ala Lys Leu Ala Lys Glu Leu Arg Ala Glu Gly Lys Thr Leu 
                165                 170                 175     


Asn Glu Asp Val Leu Met Val Asp Glu Ala His Leu Lys Ala Ile Leu 
            180                 185                 190         


Tyr Ser Asp Ala Lys Arg Lys Leu Leu Arg Tyr Phe Gly Gly Ser Ser 
        195                 200                 205             


Ala Cys Glu Ala Leu Gly Leu Asp Lys Asp Lys Met Val Leu Glu Phe 
    210                 215                 220                 


Arg Gln Ile Phe Arg Gly Leu Arg Asn Ser Ala Phe His Tyr Thr Asp 
225                 230                 235                 240 


Gly Lys Lys Ala Asp Ile Lys Phe Asp Val Thr Arg Gln Leu Trp Ile 
                245                 250                 255     


Gln Asp Val Gln Ala Asn Lys Gln Leu Ile Leu Asp Lys Tyr Tyr Ser 
            260                 265                 270         


Asn Asn Val Cys Arg Tyr Tyr Lys Pro Glu Met Val Lys Lys Leu Ile 
        275                 280                 285             


Gly Asn Leu Tyr His Gly Tyr Val Glu Gln Glu Ala Gln Ile Pro Ala 
    290                 295                 300                 


Phe Arg Thr Val Trp Lys Arg Lys Asp Phe Ala Lys Tyr Leu Asn Asp 
305                 310                 315                 320 


Ser Asn Phe Leu Pro Val Asn Ile Lys Asn Asp Val Lys Glu Arg Thr 
                325                 330                 335     


Val Phe Glu Gly Ala Leu Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg 
            340                 345                 350         


Lys Tyr Thr Val Gly Gln Asp Ala Pro Lys Tyr Phe Phe Glu Ala Val 
        355                 360                 365             


Arg Ala Tyr Ser Asp Glu His Ala Lys Asn Lys Gln Asp Pro Tyr Ala 
    370                 375                 380                 


Asn Gln Ala Lys Asn Phe Trp Asp Tyr Val Glu Lys Leu Gln Lys Ser 
385                 390                 395                 400 


Tyr Glu Lys Gly Thr Leu Thr Phe Gly Ala Val Cys Gln Thr Ile Met 
                405                 410                 415     


Thr Glu Phe Val Gln Gln Asn Ser Lys Ala Thr Glu Lys Glu Gly Glu 
            420                 425                 430         


Ile Tyr Gln His Phe Lys Val Leu Phe Pro Leu Cys Met Gln Arg Gly 
        435                 440                 445             


Phe Glu Lys Tyr Val Lys Glu Lys His Gly Tyr Leu Leu Lys Pro Trp 
    450                 455                 460                 


Leu Asp Thr Val Val Arg Glu Asn Val Leu Gln Asp Ala Ala Ile Thr 
465                 470                 475                 480 


Cys Phe Asp Asp Leu Met Arg Asp Ala Glu Asp Arg Glu Tyr Ser Trp 
                485                 490                 495     


Tyr Val Val Ala His Phe Ile His Pro Lys Lys Leu Asn His Phe Val 
            500                 505                 510         


Gly Ala Leu Lys Asp Tyr Leu Gln Phe Lys Gln Asp Ile Phe Arg Arg 
        515                 520                 525             


Cys Ser Phe Ala Asn Ile Tyr Ser Glu Gly Glu Leu Ser Gln Lys Lys 
    530                 535                 540                 


Ala Met Leu Ala Glu Lys Glu Ala Glu Ile Ser Glu Ile Leu Arg Val 
545                 550                 555                 560 


Met Glu Phe Val Arg Gly Ile Thr Gly Arg Val Ser Lys Thr Phe Ser 
                565                 570                 575     


Asp Tyr Tyr Glu Asn Glu Glu Val Tyr Ala Asn Tyr Leu Gly Lys Tyr 
            580                 585                 590         


Ile Asp Phe Pro Lys Thr Asp Gly Ile Ser Val Phe Glu Ser Phe Arg 
        595                 600                 605             


Asp Phe Cys Thr Asn Thr Leu Pro Asp Gly Asn Val Leu Asp Val Tyr 
    610                 615                 620                 


Met Asp Glu Lys Asn Pro Arg Leu Leu Lys Asn Val Glu Leu Ala Arg 
625                 630                 635                 640 


Met Tyr Ala Gly Gly Asp Val Ala Leu Lys Lys Arg Lys Arg Ile Thr 
                645                 650                 655     


Ala Lys Asp Leu Gln Arg Tyr Tyr Gly Asn Glu Val Ala Val Gln Lys 
            660                 665                 670         


Ile Leu Gln Lys Gly Leu Cys Ser Thr Arg Glu Glu Gln Gln Arg Val 
        675                 680                 685             


Leu Glu Gln Gln Asn Leu Arg Gly Arg Ile Thr Leu Asn Asp Val Thr 
    690                 695                 700                 


Glu Ile Gln Glu Ile Ile Ser Asp Met Leu Ser Gln Leu Val Thr Phe 
705                 710                 715                 720 


Ser Tyr Phe Arg Glu Arg Asp Gln Met Tyr Leu Leu Leu Gly Phe Tyr 
                725                 730                 735     


Tyr Met Ala Leu Gln Thr Asn Arg Gly Ser Ser Trp Gly Asn Glu Thr 
            740                 745                 750         


Ile Asp Phe Cys Ala Gly Lys Lys Ile Ser Ile Lys Gln Gly Trp Val 
        755                 760                 765             


Leu His Gln Val Arg Ser Val Phe Thr Tyr Gly Leu Lys Leu Tyr Ser 
    770                 775                 780                 


Glu Leu Asp Glu Lys Gly Val Gly Gly Gln Leu Ser Ser Lys Ile Val 
785                 790                 795                 800 


Ala Phe Glu Arg Val His Arg Thr Ser Leu Ala Cys Ala Leu Arg Leu 
                805                 810                 815     


Phe Met Asp Glu Asn Cys Ser Arg Arg Ala Val Asp Val Arg Asn Tyr 
            820                 825                 830         


Val Asp His Phe Lys Tyr Tyr Phe Lys Ala Asp Arg Ser Ile Met Glu 
        835                 840                 845             


Leu Tyr Ser Ala Tyr Tyr Asp Cys Phe Phe Asp Tyr Ser Thr Lys Met 
    850                 855                 860                 


Arg Lys Ser Val Leu Leu Asn Phe Ile Ser Ile Leu Glu Arg His Phe 
865                 870                 875                 880 


Val Val Ser Lys Leu Arg Val Asn Cys Leu Glu Glu Arg Cys Ser Val 
                885                 890                 895     


Ser Phe Ala Glu Ser Leu Lys Ser Glu Lys Phe Thr Tyr Lys Leu Glu 
            900                 905                 910         


Ala Asp Ala Asn Lys Lys Ser Lys Glu Gln Thr Val Glu Phe Pro Ala 
        915                 920                 925             


Arg Asp Lys Glu Phe Leu Glu Ser Leu Gln Ala Glu Leu Glu Tyr Lys 
    930                 935                 940                 


Glu Gly Tyr Asn Ser 
945                 


<210>  1235
<211>  1142
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1235

Met Leu Arg Arg Met Cys Met Lys Ile Thr Lys Ile Asp Gly Ile Ser 
1               5                   10                  15      


His Lys Lys Tyr Lys Glu Lys Gly Lys Leu Ile Lys Ser Asn Glu Ile 
            20                  25                  30          


Glu Lys Asp Ile Thr Glu Glu Arg Phe Asn Asp Ile Glu Ala Lys Thr 
        35                  40                  45              


Thr Glu Leu Phe Gln Lys Thr Leu Asp Phe Tyr Val Lys Asn Tyr Glu 
    50                  55                  60                  


Asn Ser Glu Asp Gln Asn Lys Glu Arg Arg Glu Lys Ala Lys Asn Tyr 
65                  70                  75                  80  


Phe Ser Lys Val Lys Ile Leu Val Asp Asn Lys Lys Ile Thr Ile Cys 
                85                  90                  95      


Asn Glu Asn Thr Glu Lys Met Glu Ile Glu Asp Phe Asn Glu Tyr Asp 
            100                 105                 110         


Val Arg Ser Gly Lys Tyr Phe Asn Val Leu Asn Lys Ile Leu Asn Gly 
        115                 120                 125             


Glu Asn Tyr Thr Glu Glu Asp Leu Glu Val Phe Glu Asn Asp Leu Gln 
    130                 135                 140                 


Lys Arg Ile Gly Arg Ile Lys Ser Ile Lys Asn Ser Leu Glu Glu Asn 
145                 150                 155                 160 


Lys Ala His Phe Lys Lys Glu Ser Ile Asn Asn Asn Ile Ile Tyr Asp 
                165                 170                 175     


Arg Val Lys Gly Asn Asn Lys Lys Ser Leu Phe Tyr Glu Tyr Tyr Arg 
            180                 185                 190         


Ile Ser Ser Lys His Gln Glu Tyr Val Asn Asn Ile Phe Glu Ala Phe 
        195                 200                 205             


Asp Lys Leu Tyr Ser Asn Ser His Glu Ala Met Asn Asn Leu Phe Ser 
    210                 215                 220                 


Glu Ile Thr Lys Asp Ser Lys Asp Arg Asn Ile Arg Lys Ile Arg Glu 
225                 230                 235                 240 


Ala Tyr His Glu Ile Leu Asn Lys Asn Lys Thr Glu Phe Gly Glu Glu 
                245                 250                 255     


Leu Tyr Lys Lys Ile Gln Asp Asn Arg Asn Asn Phe Asp Lys Leu Leu 
            260                 265                 270         


Glu Ile Glu Pro Glu Ile Lys Glu Leu Thr Lys Ser Gln Ile Phe Tyr 
        275                 280                 285             


Lys Tyr Tyr Ile Asp Lys Val Asn Leu Asp Glu Thr Ser Ile Lys His 
    290                 295                 300                 


Cys Phe Cys His Leu Val Glu Ile Glu Val Asn Gln Leu Leu Lys Asn 
305                 310                 315                 320 


Tyr Val Tyr Ser Lys Arg Asn Ile Asn Lys Glu Lys Leu Glu Asn Ile 
                325                 330                 335     


Phe Glu Tyr Cys Lys Leu Arg Asn Leu Val Lys Asn Lys Leu Val Asn 
            340                 345                 350         


Lys Leu Asn Asn Tyr Ile Arg Asn Cys Gly Lys Tyr Asn Ala Tyr Ile 
        355                 360                 365             


Ser Asn Asn Asp Val Val Val Asn Ser Glu Lys Ile Ser Glu Ile Arg 
    370                 375                 380                 


Thr Lys Glu Ala Phe Leu Arg Ser Ile Ile Gly Val Ser Ser Ser Ala 
385                 390                 395                 400 


Tyr Phe Ser Leu Arg Asn Ile Leu Asn Thr Asp Asn Thr Gln Asp Ile 
                405                 410                 415     


Thr Asn Lys Val Asp Lys Glu Val Asp Lys Leu Tyr Gln Glu Asn Lys 
            420                 425                 430         


Lys Ile Glu Leu Glu Glu Arg Leu Lys Leu Phe Phe Gly Asn Tyr Phe 
        435                 440                 445             


Asp Ile Asn Asn Gln Gln Glu Ile Lys Val Phe Leu Met Asn Ile Asp 
    450                 455                 460                 


Lys Ile Ile Ser Ser Ile Arg His Glu Ile Ile His Phe Lys Met Glu 
465                 470                 475                 480 


Ala Asn Ala Gln Asn Ile Phe Asp Phe Asn Asn Val Asn Leu Gly Asn 
                485                 490                 495     


Thr Ala Lys Asn Ile Phe Ser Asn Glu Ile Asn Glu Glu Lys Ile Lys 
            500                 505                 510         


Phe Lys Ile Phe Lys Gln Leu Asn Ser Ala Asn Val Phe Asp Tyr Leu 
        515                 520                 525             


Ser Asn Lys Asp Ile Thr Glu Tyr Met Asp Lys Ala Val Phe Ser Phe 
    530                 535                 540                 


Thr Asn Arg Asn Val Ser Phe Val Pro Ser Phe Thr Lys Ile Tyr Asn 
545                 550                 555                 560 


Arg Val Gln Asp Leu Ala Asn Ser Leu Glu Ile Lys Glu Trp Lys Ile 
                565                 570                 575     


Pro Asp Glu Ser Glu Gly Lys Asp Ala Gln Ile Tyr Leu Leu Lys Asn 
            580                 585                 590         


Ile Tyr Tyr Gly Lys Phe Leu Asp Lys Phe Leu Asn Glu Glu Asn Gly 
        595                 600                 605             


Ile Phe Ile Ser Ile Lys Asp Lys Ile Ile Glu Leu Asn Arg Asn Gln 
    610                 615                 620                 


Asn Lys Arg Thr Gly Phe Tyr Lys Leu Glu Lys Phe Glu Lys Ile Glu 
625                 630                 635                 640 


Glu Thr Asn Pro Lys Lys Tyr Leu Glu Ile Ile Gln Ser Leu Tyr Met 
                645                 650                 655     


Ile Asn Ile Glu Glu Ile Asp Ser Glu Gly Lys Asn Ile Phe Leu Asp 
            660                 665                 670         


Phe Ile Gln Lys Ile Phe Leu Lys Gly Phe Phe Glu Phe Ile Lys Asn 
        675                 680                 685             


Asp Tyr Asn Tyr Leu Leu Glu Leu Lys Lys Val Gln Asp Lys Lys Asn 
    690                 695                 700                 


Ile Phe Asp Ser Lys Met Ser Glu Tyr Ile Ala Gly Glu Lys Thr Leu 
705                 710                 715                 720 


Glu Asp Met Glu Glu Ile Asn Glu Ile Ile Gln Asp Ile Lys Ile Thr 
                725                 730                 735     


Glu Ile Asp Lys Ile Leu Asn Gln Thr Asp Arg Ile Asn Cys Phe Tyr 
            740                 745                 750         


Leu Leu Leu Lys Leu Leu Asn Tyr Lys Glu Ile Thr Glu Leu Lys Gly 
        755                 760                 765             


Asn Leu Glu Lys Tyr Gln Ile Leu Ser Lys Thr Asn Ile Tyr Glu Lys 
    770                 775                 780                 


Glu Leu Met Leu Leu Asn Ile Val Asn Leu Asp Asn Asn Lys Val Lys 
785                 790                 795                 800 


Ile Glu Asn Phe Lys Ile Ser Ala Glu Glu Ile Gly Lys Phe Ile Glu 
                805                 810                 815     


Glu Ile Asn Lys Asn Lys Lys Ile Lys Thr Phe Glu Glu Leu Arg Asn 
            820                 825                 830         


Phe Glu Lys Gly Glu Asn Thr Gly Glu Tyr Tyr Asn Ile Tyr Ser Asp 
        835                 840                 845             


Asp Lys Asn Ile Lys Asn Ile Arg Asn Leu Tyr Asn Ile Lys Lys Tyr 
    850                 855                 860                 


Gly Met Leu Asp Leu Leu Glu Lys Ile Ser Glu Lys Thr Asn Tyr Cys 
865                 870                 875                 880 


Ile Lys Lys Lys Asp Leu Glu Glu Tyr Ser Lys Leu Arg Lys Gln Leu 
                885                 890                 895     


Glu Asp Glu Lys Thr Asn Phe Tyr Glu Ile Gln Lys Tyr Leu His Phe 
            900                 905                 910         


Lys Tyr Gln Gln Lys Pro Lys Lys Ile Leu Trp Lys Asn Asn Lys Asn 
        915                 920                 925             


Asp Tyr Glu Lys Tyr Lys Lys Ser Ile Glu Asn Ile Glu Lys Tyr Val 
    930                 935                 940                 


His Leu Lys Asn Lys Ile Glu Phe Asn Glu Leu Asn Leu Leu Gln Ser 
945                 950                 955                 960 


Leu Leu Leu Lys Ile Leu His Arg Leu Val Gly Phe Thr Ser Ile Trp 
                965                 970                 975     


Glu Arg Asp Leu Arg Phe Arg Leu Thr Gly Glu Phe Pro Asp Glu Leu 
            980                 985                 990         


Asp Val Glu Asp Ile Phe Asp His  Arg Lys Arg Tyr Lys  Gly Thr Gly 
        995                 1000                 1005             


Gly Gly  Ile Cys Lys Lys Tyr  Asp Arg Phe Ile Asn  Thr Tyr Thr 
    1010                 1015                 1020             


Glu Tyr  Asn Asn Lys Met Lys  Asn Val Lys Phe Ala  Asp Asn Asn 
    1025                 1030                 1035             


Pro Val  Arg Asn Tyr Ile Ala  His Phe Asn Tyr Leu  Pro Thr Pro 
    1040                 1045                 1050             


Lys Tyr  Ser Ile Leu Lys Met  Met Glu Lys Leu Arg  Lys Leu Leu 
    1055                 1060                 1065             


Asp Tyr  Asp Arg Lys Leu Lys  Asn Ala Val Met Lys  Ser Ile Lys 
    1070                 1075                 1080             


Asp Ile  Leu Glu Glu Tyr Gly  Phe Lys Ala Glu Phe  Ile Ile Asn 
    1085                 1090                 1095             


Ser Asp  Lys Glu Ile Ile Leu  Asn Ser Val Lys Ser  Val Glu Ile 
    1100                 1105                 1110             


Ile His  Leu Gly Lys Glu Asp  Leu Lys Ser His Arg  Asn Ser Glu 
    1115                 1120                 1125             


Asp Leu  Cys Lys Leu Val Lys  Ala Met Leu Glu Tyr  Ser Lys 
    1130                 1135                 1140         


<210>  1236
<211>  1175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1236

Met Lys Val Thr Lys Ile Asp Gly Leu Ser His Lys Lys Phe Glu Asp 
1               5                   10                  15      


Glu Gly Lys Leu Val Ile Ile Glu Asp Ala Ser Gln Lys Asn Glu Thr 
            20                  25                  30          


Leu Glu Arg Leu Glu Asn Leu Lys Gly Ile Lys Leu Gly Asn Tyr Ile 
        35                  40                  45              


Lys Asn Pro Asp Lys Thr Lys Asn Lys Asp Asn Lys Lys Arg Arg Lys 
    50                  55                  60                  


Gly Leu Lys Glu Tyr Phe Ser Glu Ile Thr Leu Arg Lys Glu Asn Glu 
65                  70                  75                  80  


Lys Tyr Val Leu Leu Lys Gly Lys Lys Leu Lys Lys Ile Asn Asn Asp 
                85                  90                  95      


Ile Lys Asp Thr Asp Ile Lys Ala Lys Asp Lys Lys Glu Glu Val Phe 
            100                 105                 110         


Asp Ile Leu Lys Glu Ile Leu Lys Leu Asn Leu Leu Val Asn Asp Ala 
        115                 120                 125             


Glu Glu Lys Ile Gln Phe Asp Ser Ile Lys Leu Lys Asn Val Phe Gly 
    130                 135                 140                 


Lys Asp Phe Val Lys Lys Glu Leu Gln Ile Lys Ser Ile Glu Glu Ser 
145                 150                 155                 160 


Leu Glu Lys Asn Lys Ala Asp Tyr Arg Lys Glu Phe Ile Glu Thr Glu 
                165                 170                 175     


Asn His Lys Tyr Glu Asn Val Lys Gly Lys Asn Lys Arg Ser Arg Ile 
            180                 185                 190         


Tyr Glu Tyr Tyr Lys Lys Ser Glu Asn His Lys Lys Phe Glu Asp Asn 
        195                 200                 205             


Ile Arg Glu Ala Phe Glu Lys Leu Tyr Thr Glu Glu Asn Ile Lys Glu 
    210                 215                 220                 


Leu Tyr Ser Lys Ile Glu Gln Val Leu Lys Lys Thr His Leu Lys Ser 
225                 230                 235                 240 


Ile Val Arg Glu Phe Tyr Lys Asn Glu Ile Ile Gly Glu Ser Glu Phe 
                245                 250                 255     


Ser Lys Lys Asn Gly Asp Gly Ile Ser Ile Leu Tyr Asn Gln Ile Lys 
            260                 265                 270         


Asp Ser Ile Lys Lys Glu Glu Asn Phe Ile Glu Phe Ile Glu Asn Ile 
        275                 280                 285             


Gly Asn Leu Glu Leu Lys Asp Leu Thr Lys Ser Gln Ile Phe Tyr Lys 
    290                 295                 300                 


Tyr Phe Leu Glu Asn Glu Gly Leu Asn Asp Glu Asn Ile Lys Phe Val 
305                 310                 315                 320 


Phe Cys Tyr Phe Val Glu Ile Glu Val Ser Asp Leu Leu Lys Gly Asn 
                325                 330                 335     


Ile Tyr Lys Ala Ser Lys Ile Tyr Glu Asn Lys Ile Lys Asn Ile Phe 
            340                 345                 350         


Glu Tyr Gly Lys Leu Lys Asn Leu Ile Val Tyr Lys Leu Glu Asn Lys 
        355                 360                 365             


Leu Asn Asn Tyr Val Arg Asn Cys Gly Lys Tyr Asn Tyr His Met Glu 
    370                 375                 380                 


Asn Gly Asp Thr Ala Thr Ser Asp Ile Asn Met Arg Asn Arg Gln Thr 
385                 390                 395                 400 


Glu Ala Phe Leu Arg Ser Met Ile Gly Val Ser Ser Phe Gly Tyr Phe 
                405                 410                 415     


Ser Leu Arg Asn Ile Leu Gly Val Asn Asp Asp Asp Phe Tyr Glu Thr 
            420                 425                 430         


Glu Glu Asp Leu Thr Lys Ala Lys Lys Asp Ile Thr Ile Lys Lys Ile 
        435                 440                 445             


Phe Glu Glu Val Val Asp Lys Ser Phe Glu Lys Lys Gly Ile Tyr Ser 
    450                 455                 460                 


Ile Arg Lys Asn Val Lys Met Phe Tyr Gly Asp Ser Phe Asp Lys Ala 
465                 470                 475                 480 


Asn Glu Asp Glu Leu Lys Gln Phe Phe Val Asn Met Leu Asn Ala Ile 
                485                 490                 495     


Thr Ser Ile Arg His Arg Val Val His Tyr Asn Met Asn Thr Asn Ser 
            500                 505                 510         


Glu Asn Ile Phe Asn Phe Ser Asp Ile Glu Val Ser Arg Leu Leu Lys 
        515                 520                 525             


Asn Ile Phe Glu Lys Glu Thr Asp Lys Arg Glu Leu Lys Leu Lys Ile 
    530                 535                 540                 


Phe Arg Gln Leu Asn Ser Ala Gly Val Phe Asp Tyr Trp Glu Ser Trp 
545                 550                 555                 560 


Lys Ile Lys Lys Tyr Leu Glu Asn Ile Glu Phe Lys Phe Val Asn Lys 
                565                 570                 575     


Asn Ile Pro Phe Val Pro Ser Phe Thr Lys Leu Tyr Asn Arg Ile Asp 
            580                 585                 590         


Asn Leu Lys Gly Ser Asn Ala Leu Asn Leu Gly Tyr Ile Asn Ile Pro 
        595                 600                 605             


Lys Arg Lys Glu Val Arg Asp Ser Gln Ile Tyr Leu Leu Lys Asn Ile 
    610                 615                 620                 


Tyr Tyr Gly Glu Phe Val Glu Lys Phe Val Asn Asn Asn Asp Asn Phe 
625                 630                 635                 640 


Glu Lys Ile Phe Arg Glu Ile Ile Glu Ile Asn Lys Asn Ala Gly Thr 
                645                 650                 655     


Asn Thr Lys Thr Lys Phe Tyr Lys Leu Glu Lys Phe Glu Thr Leu Lys 
            660                 665                 670         


Ala Asn Thr Pro Thr Glu Tyr Leu Glu Lys Leu Gln Ser Leu His Gln 
        675                 680                 685             


Ile Asn Tyr Asp Arg Glu Lys Ile Glu Glu Ala Lys Asp Ile Tyr Val 
    690                 695                 700                 


Asp Phe Val Gln Lys Ile Phe Leu Lys Gly Phe Ile Asn Tyr Leu Gln 
705                 710                 715                 720 


Lys Ser Asn Ser Leu Lys Pro Leu Asn Leu Leu Asn Leu Lys Lys Asp 
                725                 730                 735     


Glu Val Ile Asn Ser Glu Lys Ser Ser Tyr Asp Glu Lys Leu Lys Gln 
            740                 745                 750         


Trp Glu Asn Asn Gly Ser Asn Leu Ser Lys Met Pro Glu Glu Ile Tyr 
        755                 760                 765             


Glu Tyr Ile Lys Lys Ile Gln Ile Asn Lys Ile Asn Tyr Ser Asp Arg 
    770                 775                 780                 


Met Ser Ile Phe Tyr Leu Leu Leu Lys Leu Ile Asp His Arg Glu Leu 
785                 790                 795                 800 


Thr Asn Leu Arg Gly Asn Leu Glu Lys Tyr Glu Ser Met Asn Lys Asn 
                805                 810                 815     


Lys Ile Tyr Ser Glu Glu Leu Asn Ile Val Asn Leu Val Ser Leu Asp 
            820                 825                 830         


Asn Asn Lys Val Arg Thr Asn Phe Ser Val Glu Ala Glu Asp Ile Gly 
        835                 840                 845             


Lys Phe Leu Lys Thr Glu Thr Leu Ile Lys Asp Ala Arg Gln Leu Asn 
    850                 855                 860                 


Asn Phe Ser Glu Arg Phe Ser Asp Gly Glu Asn Val Ile Lys His Arg 
865                 870                 875                 880 


Ser Phe Tyr Asn Ile Lys Lys Tyr Gly Ile Leu Asp Leu Leu Glu Lys 
                885                 890                 895     


Ile Val Ala Lys Ala Asn Leu Lys Ile Thr Lys Glu Glu Ile Lys Ile 
            900                 905                 910         


Tyr Lys Asn Leu Gln Lys Glu Leu Glu Lys Asn Asp Phe Tyr Lys Ile 
        915                 920                 925             


Gln Glu Lys Ile His Arg Lys Tyr Asn Gln Lys Pro Asn Leu Ile Ser 
    930                 935                 940                 


Arg Thr Glu Asn Lys Lys Asp Phe Asn Asp Tyr Lys Lys Ala Ile Glu 
945                 950                 955                 960 


Asn Ile Gln Asn Tyr Thr Gln Leu Lys Asn Lys Ile Glu Phe Asn Asp 
                965                 970                 975     


Leu Asn Leu Leu Gln Gly Leu Leu Phe Arg Ile Leu His Arg Leu Thr 
            980                 985                 990         


Gly Tyr Thr Ser Leu Trp Glu Arg  Asp Leu Gln Phe Lys  Leu Lys Gly 
        995                 1000                 1005             


Glu Phe  Pro Glu Asp Lys Tyr  Ile Asp Glu Ile Phe  Asn Ser Asp 
    1010                 1015                 1020             


Gly Asn  Asn Asn Gln Lys Tyr  Lys Asn Gly Gly Ile  Ala Asp Lys 
    1025                 1030                 1035             


Tyr Ala  Asp Phe Leu Ile Glu  Lys Glu Glu Gly Lys  Arg Ala Gly 
    1040                 1045                 1050             


Lys Asn  Lys Ile Lys Lys Arg  Ser Glu Arg Glu Arg  Ser Phe Ile 
    1055                 1060                 1065             


Ile Arg  Asn Tyr Ile Ala His  Phe Asn Tyr Ile Pro  Asp Ala Glu 
    1070                 1075                 1080             


Lys Ser  Ile Leu Glu Ile Leu  Glu Glu Leu Arg Glu  Leu Leu Lys 
    1085                 1090                 1095             


Tyr Asp  Arg Lys Gln Lys Asn  Ala Val Met Lys Ser  Val Lys Asp 
    1100                 1105                 1110             


Ile Phe  Lys Glu Tyr Gly Phe  Ile Val Glu Phe Gly  Ile Ser His 
    1115                 1120                 1125             


Glu Asn  Asn Ser Lys Lys Ile  Lys Val Cys Asp Val  Lys Ser Glu 
    1130                 1135                 1140             


Glu Ile  Lys His Leu Lys Asn  Asn Gly Leu Leu Thr  Thr Arg Asn 
    1145                 1150                 1155             


Ser Glu  Asp Leu Cys Glu Leu  Val Lys Met Met Leu  Glu Tyr Lys 
    1160                 1165                 1170             


Lys Ser  
    1175 


<210>  1237
<211>  1184
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1237

Met Arg Val Ser Lys Val Lys Val Leu Gly Asn Glu Glu Thr Lys Gly 
1               5                   10                  15      


Arg Ile Val Leu Met His Arg Ser Pro Val Lys Gly Gln Leu Ile Tyr 
            20                  25                  30          


Ser Glu Asp Ala Gly Lys Arg Asp Arg Thr Glu Asp Ile Ile Pro Glu 
        35                  40                  45              


Gln Lys Leu Glu Ser Phe His Leu Ser Ile Leu Asn Lys Thr Phe Leu 
    50                  55                  60                  


Arg Lys Glu Phe Phe Lys Lys Glu Leu Lys His Glu Ala Lys Lys Asn 
65                  70                  75                  80  


Gly Leu Lys Gly Asp Ala Glu Asp Lys Tyr Ile Ser Glu Lys Leu Lys 
                85                  90                  95      


Glu Tyr His Ser Leu Leu Gln Phe Ile Asp Asp Val Leu Ser Val Lys 
            100                 105                 110         


Tyr Asn Glu Asn Arg Lys Ala Ile Lys Phe Pro Glu Tyr Leu Thr Arg 
        115                 120                 125             


Glu Met Ile Glu Ile Phe Leu Asn His Lys Phe Arg Lys Glu Val Thr 
    130                 135                 140                 


Tyr Thr Asn Lys Asn Gly Ala Ser Val Ser Phe Leu Leu Ser Thr Leu 
145                 150                 155                 160 


Ile Leu Asn Ala Ile Glu Lys His Ser Val Ile Glu Met Gln Pro Phe 
                165                 170                 175     


Val Asp Trp Arg Asn Trp Phe Val Glu Thr Lys Ser Lys Phe Leu Lys 
            180                 185                 190         


Lys Ser Ile Ile Asn Asn Cys Ile Pro Thr Asn Gly Gly Pro Ile Ser 
        195                 200                 205             


Arg Arg Arg Glu Thr Leu Met Lys Trp Arg Asp Asp Tyr Phe Thr Asn 
    210                 215                 220                 


Ala Glu Ile Asp Leu Ala Arg Leu His Lys Lys Phe Gly Thr Asp Thr 
225                 230                 235                 240 


Leu Met Ala Ser Leu Arg Glu Val Pro Gln Thr Glu Lys Ser Gly Asn 
                245                 250                 255     


Glu Tyr His Arg Leu Leu Lys Ser Cys Leu Gln Ser His Gln Lys Lys 
            260                 265                 270         


Leu Phe Gly Lys Arg Ala Glu Gly Tyr Asp Ile Asn Arg Ala Asp Asn 
        275                 280                 285             


Gln Leu Tyr Val Tyr Asn Thr Glu Val Val Lys Tyr Met Glu His Tyr 
    290                 295                 300                 


Phe Pro Val Lys Ser Ser Lys Arg Arg Asn Ser Thr Ala Glu Ile Lys 
305                 310                 315                 320 


Tyr Tyr Leu Gln Thr Asp Thr Ile Lys Cys Cys Leu His His Gln Ile 
                325                 330                 335     


Ile Asn Ala Val Arg Gly Leu Ala Leu Arg Glu Gly Lys Phe Asn Leu 
            340                 345                 350         


His Gly Phe Asp Asp Lys Leu Ile Pro Asn Glu Arg Asn Val Ser Ser 
        355                 360                 365             


Ser Ile Leu Asn Glu Leu Lys Thr Ser Glu Gly Phe Val Leu Asn Met 
    370                 375                 380                 


Leu Gly Gly Cys Ala Phe Ala Ala Asn Cys Leu Arg Asn Ile Val Asp 
385                 390                 395                 400 


Ala Thr Gln Arg Ser Asp Leu Leu Gly Phe Arg Cys Phe Glu Val Ser 
                405                 410                 415     


Leu Lys Lys Gly Lys Ser Asn Ser Asp Leu Phe Ala Leu Phe Phe Gly 
            420                 425                 430         


Phe Gly Arg Glu Asp Met Asp Asp Asp Ser Glu Trp Glu Lys His Leu 
        435                 440                 445             


Tyr Ala Ala Arg Tyr Ser Val Ser Glu Ile Arg Asn Arg Val Ala His 
    450                 455                 460                 


Tyr His Lys Ser Ala Ile Glu Asn Ile Tyr Asn Ile Thr Asp Phe Glu 
465                 470                 475                 480 


Tyr Arg Glu Asn Ser Met Cys Ser Tyr Thr Asp Thr Lys Phe Thr Thr 
                485                 490                 495     


Ala Leu Gln Asn Glu Ile Tyr Asn Thr Pro Lys Ala Phe Ser Leu Gln 
            500                 505                 510         


Leu Met Thr Gly Lys Val Leu Glu Tyr Tyr Pro Lys Glu Lys Leu Val 
        515                 520                 525             


Ser Phe Phe Gln Lys Tyr Lys Phe Ser Leu Tyr Arg Ser Val Val Pro 
    530                 535                 540                 


Phe Ala Pro Gly Phe Lys Asn Ile Met Arg Thr Gly Val Asn Tyr Gln 
545                 550                 555                 560 


Asn Ala Thr Gln Asn Ser Leu Phe Tyr Asp Met Gly Leu Thr Ala Phe 
                565                 570                 575     


Gln Asp Lys Asp Arg Tyr Ile Asp Asp Val Glu Ala Trp Asn Ala Arg 
            580                 585                 590         


Tyr Phe Phe Met Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Arg Phe 
        595                 600                 605             


Thr Asn Asp Lys Asn Asp Leu Phe Arg Lys Thr Val Glu Gln Val Leu 
    610                 615                 620                 


Glu Val Asn Arg Ser His Met Glu Lys Val Gly Lys Asp Asp Arg Lys 
625                 630                 635                 640 


Ala Phe Gly Glu Val Arg Gln Met Arg Glu Asn Glu Thr Ala Asn Asp 
                645                 650                 655     


Tyr Met Ala Tyr Leu Gln Ser Ser Leu Arg Met Glu Lys Asn Lys Lys 
            660                 665                 670         


Glu Leu Glu Gly Asn Gly Ala Lys Arg Ile Asn Phe Glu Lys Phe Ile 
        675                 680                 685             


Leu Gln Met Phe Val Lys Gly Phe Asp Ser Phe Leu Lys Asp Gly Ala 
    690                 695                 700                 


Phe Glu Phe Val His Ser Pro Glu Asn Cys Leu Thr Gly Ser Thr Glu 
705                 710                 715                 720 


Lys Glu Arg Ala Lys Glu Arg Asn Ser Leu Cys Glu Glu Ile Gly Asn 
                725                 730                 735     


Tyr Val Arg Leu Val Ser Thr Val Ile Asp Pro Gly Lys Gly Ser His 
            740                 745                 750         


Val Ala Phe Tyr Val Phe Cys Lys Met Leu Asn Ser Val Tyr Leu Ser 
        755                 760                 765             


Asn Ile Arg Asn Glu Met Ile Lys Tyr His Lys Val Val Arg Thr Asp 
    770                 775                 780                 


Glu Leu Ala His Leu Ile Glu Ile Ile Glu Leu Cys Leu Leu Ser Ala 
785                 790                 795                 800 


Asp Ala Val Ser Gln Lys Thr Val Asn Ala Asp Lys Leu Ser His Phe 
                805                 810                 815     


Phe Ala Glu Gly Val Asn Val Asp Asp Asp Glu Asn Val Ile His Ala 
            820                 825                 830         


Ser Met Glu Thr Phe Arg Lys Tyr Gly Thr Arg Asp Leu Phe His Lys 
        835                 840                 845             


Leu Met Leu Gln Asp Asp Arg Phe Leu Val Ser Ser Asp Asp Tyr Arg 
    850                 855                 860                 


Glu Trp Glu Glu Met Lys Glu Lys Ile Glu Gly Lys Val Lys Gln Arg 
865                 870                 875                 880 


Glu Leu Leu His Ala Glu Trp Cys Glu Ala Lys Glu Lys Asp Lys Lys 
                885                 890                 895     


Ser Arg Lys Val Lys Ser Asn Ser Arg Thr Cys Phe Glu Lys Lys Phe 
            900                 905                 910         


Met Gly Ala Lys Ala Glu Glu Tyr Tyr Ser Leu Cys Lys Val Ile Asp 
        915                 920                 925             


Lys Tyr Asn Trp Leu Asp Asn Lys Leu His Leu Val His Leu Asn Lys 
    930                 935                 940                 


Leu His Asn Leu Val Ile Glu Ile Leu Gly Arg Met Val Gly Phe Thr 
945                 950                 955                 960 


Ala Leu Phe Glu Arg Asp Phe Gln Tyr Ile Cys Lys Ser Asp Ser Glu 
                965                 970                 975     


Tyr Glu Gln Leu Tyr Asn Leu Asp Phe Asn Met Gly Leu Pro Lys Phe 
            980                 985                 990         


Lys Asn Ser Ile Lys Gly Ser Gly  Lys Ala Lys Asn Ser  Thr Gln Asn 
        995                 1000                 1005             


Ile Asp  His Asn Ala Thr Gly  Ile Gly Asn Ser Ser  Asn Leu Leu 
    1010                 1015                 1020             


Lys Glu  Asn Ser Asn Gly Thr  His Tyr Cys Lys Asn  Leu Ser Gly 
    1025                 1030                 1035             


Asp Gly  Val Glu Asp Lys Leu  Lys Arg Leu Phe Leu  Tyr Asp Asp 
    1040                 1045                 1050             


Tyr Arg  Asn Val Arg Asn Phe  Val Ala His Phe Asn  Tyr Leu Thr 
    1055                 1060                 1065             


Arg Val  Glu Asp Asp Leu Gly  Gly Asn Asp Ala Val  Lys Leu Ser 
    1070                 1075                 1080             


Gly Thr  Arg Tyr Ser Leu Ile  Glu Leu Ile Asn Glu  Leu Arg Asn 
    1085                 1090                 1095             


Leu Leu  Lys Tyr Asp Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ser 
    1100                 1105                 1110             


Phe Ile  Asp Met Phe Glu Arg  His Gly Met His Val  Lys Met Lys 
    1115                 1120                 1125             


Leu Asn  His Asn His Lys Leu  Phe Val Asp Ser Ile  Ser Pro Arg 
    1130                 1135                 1140             


Lys Ile  Lys His Leu Gly Gly  Gly Tyr Lys Lys Arg  Gly Lys Asp 
    1145                 1150                 1155             


Asp Lys  Met Tyr Val Gln Thr  Thr Asn His Val Asp  Pro Leu Tyr 
    1160                 1165                 1170             


Cys Asp  Met Cys Arg Ala Leu  Leu Glu Met Lys 
    1175                 1180                 


<210>  1238
<211>  1396
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1238

Met Gly Asn Leu Phe Gly His Lys Lys Trp Tyr Lys Ala Asp Lys Ile 
1               5                   10                  15      


Ile Lys Asp Lys Lys Gly Lys Glu Ser Thr Ile Lys Gln Glu Val Arg 
            20                  25                  30          


Ile Lys Arg Asn Tyr Ser Val Asp Arg Tyr Thr Leu Asn Thr Asn Asn 
        35                  40                  45              


Lys Val Lys Asn Asn Ile Asn Asn Glu Asp Phe Val Asn Gln Phe Ile 
    50                  55                  60                  


Glu Tyr Lys Thr Asn Asn Asp Ile Phe Lys Lys Phe Thr Lys Lys Phe 
65                  70                  75                  80  


His Met Gly Asn Ile Leu Phe Lys Leu Lys Ala Glu Glu Ser Val Lys 
                85                  90                  95      


Glu Ile Arg Asn Tyr Asn Asp Phe Leu Glu Lys Glu Lys Ala Ile Leu 
            100                 105                 110         


Glu Ile Glu Ile Tyr Gln Gln Ser Glu Glu Leu Arg Lys Lys Glu Asn 
        115                 120                 125             


Ile Thr Lys Lys Asp Ile Ile Asn Lys Val Ile Asn Asp Gly Ile Thr 
    130                 135                 140                 


Glu Asp Ser Asn Glu Ile Asn Met Lys Ile Lys Thr Lys Lys Asn Asn 
145                 150                 155                 160 


Phe Glu Glu Ile Arg Ile Ile Ile Asn Asn Glu Ser Glu Glu Tyr Tyr 
                165                 170                 175     


Ile Lys Leu Arg Ser Leu Asn Asn Asn Glu Leu Asn Leu Lys Arg Glu 
            180                 185                 190         


Ile Tyr Glu Val Leu Lys Ser Ile Asn Ala Asn Leu Tyr Thr Phe Thr 
        195                 200                 205             


Lys Asn Ala Ile Asp Asp Thr Asp Phe Lys Lys Arg Asn Tyr Glu Asn 
    210                 215                 220                 


Phe Leu Arg Glu Asn Met Met Lys His Leu Lys Lys Asn Ile Lys Glu 
225                 230                 235                 240 


Lys Tyr Glu Ile Thr Phe Phe Lys Ser Leu Ser Asn Ser Leu Lys Lys 
                245                 250                 255     


Ile Gln Gly Asn Ile Lys Lys Asn Asp Glu Ile Ile Asn Phe Ile Lys 
            260                 265                 270         


Tyr Tyr Ser Asn Ile Asn Gly Ser Lys Thr Val Ser Glu Asn Lys Lys 
        275                 280                 285             


Lys Phe Leu Glu Lys Ile Leu Asn Thr Glu Val Ser Ile Ser Glu Asn 
    290                 295                 300                 


Asp Ile Ile Asp Phe Ile Ile Gly Glu Leu Lys Phe Phe Gly Ile Ile 
305                 310                 315                 320 


Lys Arg Ile Glu Lys Leu Gln Glu Lys Thr Val Asn Arg Thr Asp Gly 
                325                 330                 335     


Asp Ile Lys Asn Thr Tyr Val Asn Thr Tyr Val Leu Leu Asp Lys His 
            340                 345                 350         


Glu Lys Phe Lys Lys Tyr Asn Arg Asn Lys Lys Asp Thr Ile Ile Lys 
        355                 360                 365             


Ser Phe Ile Lys Asn Ile Lys Asp Asn Thr Met Lys Gln Lys Ile Asn 
    370                 375                 380                 


Gln Ile Leu Arg Lys Phe Lys Ile Glu Glu Leu Ile Glu Lys Leu Arg 
385                 390                 395                 400 


Ile Lys Asn Lys Asn Phe Asp Thr Glu Ile Phe Lys Ile Phe Lys Asp 
                405                 410                 415     


His Tyr Gln Glu Met Phe Ser Ser Glu Lys Phe Glu Glu Lys Ser Asp 
            420                 425                 430         


Glu Glu Lys Glu Leu Tyr Lys Ile Ile Tyr Arg Tyr Leu Lys Glu Arg 
        435                 440                 445             


Ile Glu Lys Ile Leu Ile Asn Glu Gln Lys Val Arg Leu Lys Lys Met 
    450                 455                 460                 


Glu Lys Ile Glu Ile Glu Lys Ile Leu Asn Glu Ser Ile Leu Ser Glu 
465                 470                 475                 480 


Lys Val Leu Lys Arg Val Lys Gln Tyr Thr Leu Glu Tyr Val Met Tyr 
                485                 490                 495     


Leu Gly Lys Leu Ile His Asn Asp Val Asn Met Thr Thr Val Asn Thr 
            500                 505                 510         


Asp Asp Phe Thr Lys Leu His Ala Lys Glu Glu Leu Asp Leu Glu Leu 
        515                 520                 525             


Ile Thr Phe Phe Ala Ser Thr Asn Met Glu Leu Asn Lys Ile Phe Asn 
    530                 535                 540                 


Gly Lys Glu Lys Ile Thr Asp Phe Phe Gly Phe Asn Leu Asn Gly Gln 
545                 550                 555                 560 


Lys Ile Thr Leu Lys Glu Lys Val Pro Asp Phe Lys Leu Asn Ile Leu 
                565                 570                 575     


Lys Lys Leu Asn Phe Ile Asn Asn Glu Asn Asn Ile Asp Glu Lys Leu 
            580                 585                 590         


Ser His Phe Tyr Ser Phe Gln Lys Glu Gly Tyr Leu Leu Arg Asn Arg 
        595                 600                 605             


Ile Leu His Asn Ser Tyr Gly Asn Ile Gln Glu Thr Lys Asn Leu Glu 
    610                 615                 620                 


Gly Glu Tyr Glu Asn Val Glu Asn Leu Ile Lys Glu Leu Lys Val Ser 
625                 630                 635                 640 


Asp Glu Glu Ile Ser Lys Ser Leu Asn Leu Asp Ile Ile Phe Glu Gly 
                645                 650                 655     


Lys Val Asp Ile Ile Asn Lys Ile Asn Ser Leu Glu Ile Gly Glu Tyr 
            660                 665                 670         


Lys Asp Lys Lys Tyr Leu Pro Ser Phe Ser Lys Ile Ile Pro Glu Ile 
        675                 680                 685             


Ile Arg Lys Phe Arg Glu Ile Asn Lys Asp Lys Leu Phe Asp Glu Glu 
    690                 695                 700                 


Ser Glu Lys Ile Ile Leu Asn Val Val Lys Tyr Val Asn Lys Ile Leu 
705                 710                 715                 720 


Tyr Glu Lys Ile Thr Ser Asn Glu Glu Asn Lys Phe Ile Lys Thr Leu 
                725                 730                 735     


Pro Asp Lys Leu Val Lys Lys Asn Asn Ile Lys Lys Glu Asn Lys Asn 
            740                 745                 750         


Leu Leu Ser Ile Glu Glu Tyr Tyr Lys Asn Ala Gln Val Ser Ser Ser 
        755                 760                 765             


Lys Gly Asp Lys Lys Ala Ile Lys Lys Tyr Gln Asn Lys Val Ile Asn 
    770                 775                 780                 


Ala Tyr Leu Glu Tyr Leu Glu Asn Thr Phe Glu Lys Val Ile Asp Phe 
785                 790                 795                 800 


Ser Asn Phe Asn Leu Asn Tyr Asn Glu Ile Lys Thr Lys Ile Glu Glu 
                805                 810                 815     


Arg Lys Asn Ser Lys Asn Lys Ile Val Ile Lys Ser Ile Pro Ile Asn 
            820                 825                 830         


Ile Asn Ile Thr Asn Asp Thr Glu Tyr Ile Ile Ser Ile Phe Ala Leu 
        835                 840                 845             


Leu Asn Asn Asn Thr Tyr Leu Asn Lys Ile Arg Asn Arg Phe Phe Ala 
    850                 855                 860                 


Thr Ser Val Trp Leu Asn Thr Gln Glu Tyr Glu Asn Leu Ile Asp Ile 
865                 870                 875                 880 


Leu Asp Lys Val Leu Ser Ile Asn Leu Leu Arg Glu Asn Asn Ile Ile 
                885                 890                 895     


Asp Ile Leu Asp Leu Lys Asn Thr Ile Ile Glu Ala Lys Ile Thr Glu 
            900                 905                 910         


Asn Asn Glu Glu Tyr Ile Arg Asn Tyr Ile Phe Glu Asn Asn Lys Glu 
        915                 920                 925             


Glu Leu Lys Lys Arg Leu Phe Cys Glu Glu Leu Asp Asn Lys Glu Asp 
    930                 935                 940                 


Val Leu Lys Ile Phe Glu Asp Lys Asn Phe Lys Phe Lys Asn Phe Ile 
945                 950                 955                 960 


Lys Lys Asn Glu Ser Gly Asn Phe Lys Ile Asn Phe Ala Ile Leu Ser 
                965                 970                 975     


Asn Leu Glu Cys His Phe Glu Leu Asp Thr Lys Lys Val Ile Gly Lys 
            980                 985                 990         


Asn Ser Lys Lys Leu Glu Ser Phe  Ile Gln Asn Thr Ile  Asp Glu Tyr 
        995                 1000                 1005             


Lys Ser  Asn Ile Arg Thr Leu  Phe Ser Ser Glu Phe  Leu Glu Lys 
    1010                 1015                 1020             


Tyr Lys  Lys Glu Ile Asp Asn  Leu Met Gly Asp Ile  Glu Ser Glu 
    1025                 1030                 1035             


Asn Glu  Ser Lys Phe Glu Lys  Ile Tyr Tyr Pro Glu  Glu His Lys 
    1040                 1045                 1050             


Asn Glu  Leu Tyr Ile Tyr Lys  Lys Asn Leu Phe Leu  Asn Ile Gly 
    1055                 1060                 1065             


Asn Pro  Asn Phe Asp Lys Ile  Tyr Gly Leu Ile Ser  Lys Asp Ile 
    1070                 1075                 1080             


Lys Asn  Val Asp Thr Lys Ile  Leu Phe Asp Asp Asp  Ile Arg Lys 
    1085                 1090                 1095             


Asn Lys  Ile Ser Glu Ile Asp  Ala Ile Leu Lys Asn  Leu Asn Asp 
    1100                 1105                 1110             


Lys Leu  Asn Gly Tyr Ser Asn  Asp Tyr Lys Ala Lys  Tyr Val Asn 
    1115                 1120                 1125             


Lys Leu  Lys Glu Asn Asp Asp  Phe Phe Ala Lys Asn  Ile Gln Asn 
    1130                 1135                 1140             


Glu Asn  Tyr Ser Ser Phe Gly  Glu Phe Glu Lys Asp  Tyr Asn Lys 
    1145                 1150                 1155             


Val Ser  Glu Tyr Lys Lys Ile  Arg Asp Leu Val Glu  Phe Asn Tyr 
    1160                 1165                 1170             


Leu Asn  Lys Ile Glu Ser Tyr  Leu Ile Asp Ile Asn  Trp Lys Leu 
    1175                 1180                 1185             


Ala Ile  Gln Met Ala Arg Phe  Glu Arg Asp Met His  Tyr Ile Val 
    1190                 1195                 1200             


Asn Gly  Leu Arg Glu Leu Gly  Ile Ile Lys Leu Ser  Gly Tyr Asn 
    1205                 1210                 1215             


Thr Gly  Ile Ser Arg Ala Tyr  Pro Lys Arg Asn Gly  Ser Asp Asp 
    1220                 1225                 1230             


Phe Tyr  Ala Thr Thr Ala His  Tyr Lys Phe Phe Asp  Glu Glu Ser 
    1235                 1240                 1245             


Tyr Lys  Lys Phe Glu Lys Ile  Cys Tyr Gly Phe Arg  Ile Asp Leu 
    1250                 1255                 1260             


Ser Glu  Asn Ser Glu Ile Asn  Lys Pro Glu Asn Glu  Ser Ile Arg 
    1265                 1270                 1275             


Asn Tyr  Ile Ser His Phe Tyr  Ile Val Arg Asn Pro  Phe Val Asp 
    1280                 1285                 1290             


Tyr Ser  Ile Ala Gln Gln Ile  Asp Arg Val Ser Asn  Leu Leu Ser 
    1295                 1300                 1305             


Tyr Ser  Thr Arg Tyr Asn Asn  Ser Thr Tyr Ala Gly  Val Phe Glu 
    1310                 1315                 1320             


Val Phe  Lys Lys Asp Val Asn  Leu Asp Tyr Asp Lys  Leu Lys Thr 
    1325                 1330                 1335             


Lys Phe  Lys Leu Phe Asp Asp  Glu Lys Asn Asp Asn  Ile Lys Ile 
    1340                 1345                 1350             


Leu Lys  Ile Lys Asn Leu Ile  Glu Ser Lys Lys Val  Ser Val Leu 
    1355                 1360                 1365             


Glu Leu  Glu Ser Tyr Asn Ser  Asp Tyr Val Lys Asn  Leu Ile Ile 
    1370                 1375                 1380             


Glu Leu  Leu Thr Lys Ile Glu  Asn Thr Asn Asp Thr  Leu 
    1385                 1390                 1395     


<210>  1239
<211>  1149
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1239

Met Leu Arg Arg Met Cys Met Lys Ile Thr Lys Ile Asp Gly Ile Ser 
1               5                   10                  15      


His Lys Lys Tyr Lys Glu Lys Gly Lys Leu Ile Lys Asn Asn Asp Thr 
            20                  25                  30          


Ala Lys Asp Ile Ile Glu Glu Arg Phe Asn Asp Ile Glu Lys Lys Thr 
        35                  40                  45              


Lys Glu Leu Phe Gln Lys Thr Leu Asp Phe Tyr Val Lys Asn Tyr Glu 
    50                  55                  60                  


Lys Cys Lys Glu Gln Asn Lys Glu Arg Arg Glu Lys Ala Lys Asn Tyr 
65                  70                  75                  80  


Phe Ser Lys Val Lys Ile Leu Val Asp Asn Lys Lys Ile Thr Ile Cys 
                85                  90                  95      


Asn Glu Asn Thr Glu Lys Met Glu Ile Glu Asp Phe Asn Glu Tyr Asp 
            100                 105                 110         


Val Arg Ser Gly Lys Tyr Phe Asn Val Leu Asn Lys Ile Leu Asn Gly 
        115                 120                 125             


Glu Asn Tyr Thr Glu Glu Asp Leu Glu Val Phe Glu Asn Asp Leu Gln 
    130                 135                 140                 


Lys Arg Thr Gly Arg Ile Lys Ser Ile Lys Asn Ser Leu Glu Glu Asn 
145                 150                 155                 160 


Lys Ala His Phe Lys Lys Glu Ser Ile Asn Asn Asn Ile Ile Tyr Asp 
                165                 170                 175     


Arg Val Lys Gly Asn Asn Lys Lys Ser Leu Phe Tyr Glu Tyr Tyr Arg 
            180                 185                 190         


Ile Ser Ser Lys His Gln Glu Tyr Val Asn Asn Ile Phe Glu Ala Phe 
        195                 200                 205             


Asp Lys Leu Tyr Ser Asn Ser His Glu Ala Met Asn Asn Leu Phe Ser 
    210                 215                 220                 


Glu Ile Thr Lys Asp Ser Lys Asp Arg Asn Ile Arg Lys Ile Arg Glu 
225                 230                 235                 240 


Ala Tyr His Glu Ile Leu Asn Lys Asn Lys Thr Glu Phe Gly Glu Glu 
                245                 250                 255     


Leu Tyr Lys Lys Ile Gln Asp Asn Arg Asn Asn Phe Asp Lys Leu Leu 
            260                 265                 270         


Glu Ile Glu Pro Glu Ile Lys Glu Leu Thr Lys Ser Gln Ile Phe Tyr 
        275                 280                 285             


Lys Tyr Tyr Ile Asp Lys Val Asn Leu Asp Glu Thr Ser Ile Lys His 
    290                 295                 300                 


Cys Phe Cys His Leu Val Glu Ile Glu Val Asn Gln Leu Leu Lys Asn 
305                 310                 315                 320 


Tyr Val Tyr Ser Lys Arg Asn Ile Asn Lys Glu Lys Leu Glu Asn Ile 
                325                 330                 335     


Phe Glu Tyr Cys Lys Leu Lys Asn Leu Ile Lys Asn Lys Leu Val Asn 
            340                 345                 350         


Lys Leu Asn Asn Tyr Ile Arg Asn Cys Gly Lys Tyr Asn Ala Tyr Ile 
        355                 360                 365             


Ser Asn Asn Asp Val Val Val Asn Ser Glu Lys Ile Ser Glu Ile Arg 
    370                 375                 380                 


Thr Lys Glu Ala Phe Leu Arg Ser Ile Ile Gly Val Ser Ser Ser Ala 
385                 390                 395                 400 


Tyr Phe Ser Leu Arg Asn Ile Leu Asn Thr Asp Asn Thr Gln Asp Ile 
                405                 410                 415     


Thr Asn Lys Val Asp Lys Glu Val Asp Lys Leu Tyr Gln Glu Asn Lys 
            420                 425                 430         


Lys Ile Glu Leu Glu Glu Arg Leu Lys Leu Phe Phe Gly Asn Tyr Phe 
        435                 440                 445             


Asp Ile Asn Asn Gln Gln Glu Ile Lys Val Phe Leu Met Asn Ile Asp 
    450                 455                 460                 


Lys Ile Ile Ser Ser Ile Arg His Glu Ile Ile His Phe Lys Met Glu 
465                 470                 475                 480 


Thr Asn Ala Gln Asn Ile Phe Asp Phe Asn Asn Val Asn Leu Gly Asn 
                485                 490                 495     


Thr Ala Lys Asn Ile Phe Ser Asn Glu Ile Asn Glu Glu Lys Ile Lys 
            500                 505                 510         


Phe Lys Ile Phe Lys Gln Leu Asn Ser Ala Asn Val Phe Asp Tyr Leu 
        515                 520                 525             


Ser Asn Lys Asp Ile Thr Glu Tyr Met Asp Lys Val Val Phe Ser Phe 
    530                 535                 540                 


Thr Asn Arg Asn Val Ser Phe Val Pro Ser Phe Thr Lys Ile Tyr Asn 
545                 550                 555                 560 


Arg Val Gln Asp Leu Ala Asn Ser Leu Glu Ile Lys Lys Trp Lys Ile 
                565                 570                 575     


Pro Asp Lys Ser Glu Gly Lys Asp Ala Gln Ile Tyr Leu Leu Lys Asn 
            580                 585                 590         


Ile Tyr Tyr Gly Lys Phe Leu Asp Glu Phe Leu Asn Glu Glu Asn Gly 
        595                 600                 605             


Ile Phe Ile Ser Ile Lys Asp Lys Ile Ile Glu Leu Asn Arg Asn Gln 
    610                 615                 620                 


Asn Lys Arg Thr Gly Phe Tyr Lys Leu Glu Lys Phe Glu Lys Ile Glu 
625                 630                 635                 640 


Glu Thr Asn Pro Lys Lys Tyr Leu Glu Ile Ile Gln Ser Leu Tyr Met 
                645                 650                 655     


Ile Asn Ile Glu Glu Ile Asp Ser Glu Gly Lys Asn Ile Phe Leu Asp 
            660                 665                 670         


Phe Ile Gln Lys Ile Phe Leu Lys Gly Phe Phe Glu Phe Ile Lys Asn 
        675                 680                 685             


Asn Tyr Asn Tyr Leu Leu Glu Leu Lys Lys Ile Gln Asp Lys Lys Asn 
    690                 695                 700                 


Ile Phe Asp Ser Glu Met Ser Glu Tyr Ile Ala Gly Glu Lys Thr Leu 
705                 710                 715                 720 


Glu Asp Ile Gly Glu Ile Asn Glu Ile Ile Gln Asp Ile Lys Ile Thr 
                725                 730                 735     


Glu Ile Asp Lys Ile Leu Asn Gln Thr Asp Lys Ile Asn Cys Phe Tyr 
            740                 745                 750         


Leu Leu Leu Lys Leu Leu Asn Tyr Lys Glu Ile Thr Glu Leu Lys Gly 
        755                 760                 765             


Asn Leu Glu Lys Tyr Gln Ile Leu Ser Lys Thr Asn Val Tyr Glu Lys 
    770                 775                 780                 


Glu Leu Met Leu Leu Asn Ile Val Asn Leu Asp Asn Asn Lys Val Lys 
785                 790                 795                 800 


Ile Glu Asn Phe Lys Ile Leu Ala Glu Glu Ile Gly Lys Phe Ile Glu 
                805                 810                 815     


Lys Ile Asn Ile Glu Glu Ile Asn Lys Asn Lys Lys Ile Lys Thr Phe 
            820                 825                 830         


Glu Glu Leu Arg Asn Phe Glu Lys Gly Glu Asn Thr Gly Glu Tyr Tyr 
        835                 840                 845             


Asn Ile Tyr Ser Asp Asp Lys Asn Ile Lys Asn Ile Arg Asn Leu Tyr 
    850                 855                 860                 


Asn Ile Lys Lys Tyr Gly Met Leu Asp Leu Leu Glu Lys Ile Ser Glu 
865                 870                 875                 880 


Lys Thr Asn Tyr Cys Ile Lys Lys Lys Asp Leu Glu Glu Tyr Ser Glu 
                885                 890                 895     


Leu Arg Lys Gln Leu Glu Asp Glu Lys Thr Asn Phe Tyr Lys Ile Gln 
            900                 905                 910         


Glu Tyr Leu His Ser Lys Tyr Gln Gln Lys Pro Lys Lys Ile Leu Leu 
        915                 920                 925             


Lys Asn Asn Lys Asn Asp Tyr Glu Lys Tyr Lys Lys Ser Ile Glu Asn 
    930                 935                 940                 


Ile Glu Lys Tyr Val His Leu Lys Asn Lys Ile Glu Phe Asn Glu Leu 
945                 950                 955                 960 


Asn Leu Leu Gln Ser Leu Leu Leu Lys Ile Leu His Arg Leu Val Gly 
                965                 970                 975     


Phe Thr Ser Ile Trp Glu Arg Asp Leu Arg Phe Arg Leu Ile Gly Glu 
            980                 985                 990         


Phe Pro Asp Glu Leu Asp Val Glu  Asp Ile Phe Asp His  Arg Lys Arg 
        995                 1000                 1005             


Tyr Lys  Gly Thr Gly Lys Gly  Ile Cys Lys Lys Tyr  Asp Arg Phe 
    1010                 1015                 1020             


Ile Asn  Thr His Thr Glu Tyr  Lys Asn Asn Asn Lys  Met Glu Asn 
    1025                 1030                 1035             


Val Lys  Phe Ala Asp Asn Asn  Pro Val Arg Asn Tyr  Ile Ala His 
    1040                 1045                 1050             


Phe Asn  Tyr Leu Pro Asn Pro  Lys Tyr Ser Ile Leu  Lys Met Met 
    1055                 1060                 1065             


Glu Lys  Leu Arg Lys Leu Leu  Asp Tyr Asp Arg Lys  Leu Lys Asn 
    1070                 1075                 1080             


Ala Val  Met Lys Ser Ile Lys  Asp Ile Leu Glu Glu  Tyr Gly Phe 
    1085                 1090                 1095             


Lys Ala  Glu Phe Ile Ile Asn  Ser Asp Lys Glu Ile  Ile Leu Asn 
    1100                 1105                 1110             


Leu Val  Lys Ser Val Glu Ile  Ile His Leu Gly Lys  Glu Asp Leu 
    1115                 1120                 1125             


Lys Ser  Arg Arg Asn Ser Glu  Asp Leu Cys Lys Leu  Val Lys Ala 
    1130                 1135                 1140             


Met Leu  Glu Tyr Ser Lys 
    1145                 


<210>  1240
<211>  1184
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1240

Met Arg Val Ser Lys Val Lys Val Leu Gly Asn Glu Glu Thr Lys Gly 
1               5                   10                  15      


Arg Ile Val Leu Met His Arg Ser Pro Val Lys Gly Gln Leu Ile Tyr 
            20                  25                  30          


Ser Glu Asp Ala Gly Lys Arg Asp Arg Thr Glu Asp Ile Ile Pro Glu 
        35                  40                  45              


Gln Lys Leu Glu Ser Phe His Leu Ser Ile Leu Asn Lys Thr Phe Leu 
    50                  55                  60                  


Arg Lys Glu Phe Phe Lys Lys Glu Leu Lys His Glu Ala Lys Lys Asn 
65                  70                  75                  80  


Gly Leu Lys Gly Asp Ala Glu Asp Lys Tyr Ile Ser Glu Lys Leu Lys 
                85                  90                  95      


Glu Tyr His Ser Leu Leu Gln Phe Ile Asp Asp Val Leu Ser Val Lys 
            100                 105                 110         


Tyr Asn Glu Asn Arg Lys Ala Ile Lys Phe Pro Glu Tyr Leu Thr Arg 
        115                 120                 125             


Glu Met Ile Glu Ile Phe Leu Asn His Lys Phe Arg Lys Glu Val Thr 
    130                 135                 140                 


Tyr Thr Asn Lys Asn Gly Ala Ser Val Ser Phe Leu Leu Ser Thr Leu 
145                 150                 155                 160 


Ile Leu Asn Ala Ile Glu Lys His Ser Val Ile Glu Met Gln Pro Phe 
                165                 170                 175     


Val Asp Trp Arg Asn Trp Phe Val Glu Thr Lys Ser Lys Phe Leu Lys 
            180                 185                 190         


Lys Ser Ile Ile Asn Asn Cys Ile Pro Thr Asn Gly Gly Pro Ile Ser 
        195                 200                 205             


Arg Arg Arg Glu Thr Leu Met Lys Trp Arg Asp Asp Tyr Phe Thr Asn 
    210                 215                 220                 


Ala Glu Ile Asp Leu Ala Arg Leu His Lys Lys Phe Gly Thr Asp Thr 
225                 230                 235                 240 


Leu Met Ala Ser Leu Arg Glu Val Pro Gln Thr Glu Lys Ser Gly Asn 
                245                 250                 255     


Glu Tyr His Arg Leu Leu Lys Ser Cys Leu Gln Ser His Gln Lys Lys 
            260                 265                 270         


Leu Phe Gly Lys Arg Ala Glu Gly Tyr Asp Ile Asn Arg Ala Asp Asn 
        275                 280                 285             


Gln Leu Tyr Val Tyr Asn Thr Glu Val Val Lys Tyr Met Glu His Tyr 
    290                 295                 300                 


Phe Pro Val Lys Ser Ser Lys Arg Arg Asn Ser Thr Ala Glu Ile Lys 
305                 310                 315                 320 


Tyr Tyr Leu Gln Thr Asp Thr Ile Lys Cys Cys Leu His His Gln Ile 
                325                 330                 335     


Ile Asn Ala Val Arg Gly Leu Ala Leu Arg Glu Gly Lys Phe Asn Leu 
            340                 345                 350         


His Gly Phe Asp Asp Lys Leu Ile Pro Asn Glu Arg Asn Val Ser Ser 
        355                 360                 365             


Ser Ile Leu Asn Glu Leu Lys Thr Ser Glu Gly Phe Val Leu Asn Met 
    370                 375                 380                 


Leu Gly Gly Cys Ala Phe Ala Ala Asn Cys Leu Arg Asn Ile Val Asp 
385                 390                 395                 400 


Ala Thr Gln Arg Ser Asp Leu Leu Gly Phe Arg Cys Phe Glu Val Ser 
                405                 410                 415     


Leu Lys Lys Gly Lys Ser Asn Ser Asp Leu Phe Ala Leu Phe Phe Gly 
            420                 425                 430         


Phe Gly Arg Glu Asp Met Asp Asp Asp Ser Glu Trp Glu Lys His Leu 
        435                 440                 445             


Tyr Ala Ala Arg Tyr Ser Val Ser Glu Ile Arg Asn Arg Val Ala His 
    450                 455                 460                 


Tyr His Lys Ser Ala Ile Glu Asn Ile Tyr Asn Ile Thr Asp Phe Glu 
465                 470                 475                 480 


Tyr Arg Glu Asn Ser Met Cys Ser Tyr Thr Asp Thr Lys Phe Thr Thr 
                485                 490                 495     


Ala Leu Gln Asn Glu Ile Tyr Asn Thr Pro Lys Ala Phe Ser Leu Gln 
            500                 505                 510         


Leu Met Thr Gly Lys Val Leu Glu Tyr Tyr Pro Lys Glu Lys Leu Val 
        515                 520                 525             


Ser Phe Phe Gln Lys Tyr Lys Phe Ser Leu Tyr Arg Ser Val Val Pro 
    530                 535                 540                 


Phe Ala Pro Gly Phe Lys Asn Ile Met Arg Thr Gly Val Asn Tyr Gln 
545                 550                 555                 560 


Asn Ala Thr Gln Asn Arg Leu Phe Tyr Asp Met Gly Leu Thr Ala Phe 
                565                 570                 575     


Gln Asp Lys Asp Arg Tyr Ile Asp Asp Val Glu Ala Trp Asn Ala Arg 
            580                 585                 590         


Tyr Phe Phe Met Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Arg Phe 
        595                 600                 605             


Thr Asn Asp Lys Asn Asp Leu Phe Arg Lys Thr Val Glu Gln Val Leu 
    610                 615                 620                 


Glu Val Asn Arg Ser His Met Glu Lys Val Gly Lys Asp Asp Arg Gln 
625                 630                 635                 640 


Ala Phe Gly Glu Val Arg Gln Met Arg Glu Asn Glu Thr Ala Asn Asp 
                645                 650                 655     


Tyr Met Ala Tyr Leu Gln Ser Ser Leu Arg Met Glu Lys Asn Lys Lys 
            660                 665                 670         


Glu Leu Glu Gly Asn Gly Ala Lys Arg Ile Asn Phe Glu Lys Phe Ile 
        675                 680                 685             


Leu Gln Met Phe Val Lys Gly Phe Asp Ser Phe Leu Lys Asp Gly Ala 
    690                 695                 700                 


Phe Glu Phe Val His Ser Pro Glu Asn Cys Leu Thr Gly Ser Thr Glu 
705                 710                 715                 720 


Lys Glu Arg Ala Lys Glu Arg Asn Ser Leu Cys Glu Glu Ile Gly Asn 
                725                 730                 735     


Tyr Val Arg Leu Val Ser Thr Val Ile Asp Pro Gly Lys Gly Ser His 
            740                 745                 750         


Val Ala Phe Tyr Val Phe Cys Lys Met Leu Asn Ser Val Tyr Leu Ser 
        755                 760                 765             


Asn Ile Arg Asn Glu Met Ile Lys Tyr His Lys Val Val Arg Thr Asp 
    770                 775                 780                 


Glu Leu Ala His Leu Ile Glu Ile Ile Glu Leu Cys Leu Leu Ser Ala 
785                 790                 795                 800 


Asp Ala Val Ser Gln Lys Thr Val Asn Ala Asp Lys Leu Ser His Phe 
                805                 810                 815     


Phe Ala Glu Gly Val Asn Val Asp Asp Asp Glu Asn Val Ile His Ala 
            820                 825                 830         


Ser Met Glu Thr Phe Arg Lys Tyr Gly Thr Arg Asp Leu Phe His Lys 
        835                 840                 845             


Leu Met Leu Gln Asp Asp Arg Phe Leu Val Ser Ser Asp Asp Tyr Arg 
    850                 855                 860                 


Glu Trp Glu Glu Met Lys Glu Lys Ile Glu Gly Lys Val Lys Gln Arg 
865                 870                 875                 880 


Glu Leu Leu His Ala Glu Trp Cys Glu Ala Lys Glu Lys Asp Lys Lys 
                885                 890                 895     


Ser Arg Lys Val Lys Ser Asn Ser Arg Thr Cys Phe Glu Lys Lys Phe 
            900                 905                 910         


Met Gly Ala Lys Ala Glu Glu Tyr Tyr Ser Leu Cys Asn Val Ile Asp 
        915                 920                 925             


Lys Tyr Asn Trp Leu Asp Asn Lys Leu His Leu Val His Leu Asn Lys 
    930                 935                 940                 


Leu His Asn Leu Val Ile Glu Ile Leu Gly Arg Met Val Gly Phe Thr 
945                 950                 955                 960 


Ala Leu Phe Glu Arg Asp Phe Gln Tyr Ile Cys Lys Ser Asp Ser Glu 
                965                 970                 975     


Tyr Glu Gln Leu Tyr Asn Leu Asp Phe Asn Met Gly Leu Pro Lys Phe 
            980                 985                 990         


Lys Asn Ser Ile Lys Gly Ser Gly  Lys Ala Lys Asn Ser  Thr Gln Asn 
        995                 1000                 1005             


Ile Asp  His Asn Ala Thr Gly  Ile Gly Asn Ser Ser  Asn Leu Leu 
    1010                 1015                 1020             


Lys Glu  Asn Ser Asn Gly Thr  His Tyr Cys Lys Asn  Leu Ser Gly 
    1025                 1030                 1035             


Asp Gly  Val Glu Asp Lys Leu  Lys Arg Leu Phe Leu  Tyr Asp Asp 
    1040                 1045                 1050             


Tyr Arg  Asn Val Arg Asn Phe  Val Ala His Phe Asn  Tyr Leu Thr 
    1055                 1060                 1065             


Arg Val  Glu Asp Asp Leu Gly  Gly Asn Asp Ala Val  Lys Leu Ser 
    1070                 1075                 1080             


Gly Thr  Arg Tyr Ser Leu Ile  Glu Leu Ile Asn Glu  Leu Arg Asn 
    1085                 1090                 1095             


Leu Leu  Lys Tyr Asp Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ser 
    1100                 1105                 1110             


Phe Ile  Asp Met Phe Glu Arg  His Gly Met His Val  Lys Met Lys 
    1115                 1120                 1125             


Leu Asn  His Asn His Lys Leu  Phe Val Asp Ser Ile  Ser Pro Arg 
    1130                 1135                 1140             


Lys Ile  Lys His Leu Gly Gly  Gly Tyr Lys Lys Arg  Gly Lys Asp 
    1145                 1150                 1155             


Asp Lys  Met Tyr Val Gln Thr  Thr Asn His Val Asp  Pro Leu Tyr 
    1160                 1165                 1170             


Cys Asp  Met Cys Arg Ala Leu  Leu Glu Met Lys 
    1175                 1180                 


<210>  1241
<211>  1184
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1241

Met Arg Val Ser Lys Val Lys Val Leu Gly Asn Glu Glu Thr Lys Gly 
1               5                   10                  15      


Arg Ile Val Leu Met His Arg Ser Pro Val Lys Gly Gln Leu Ile Tyr 
            20                  25                  30          


Ser Glu Asp Ala Gly Lys Arg Asp Arg Thr Glu Asp Ile Ile Pro Glu 
        35                  40                  45              


Gln Lys Leu Glu Ser Phe His Leu Ser Ile Leu Asn Lys Thr Phe Leu 
    50                  55                  60                  


Arg Lys Glu Phe Phe Lys Lys Glu Leu Lys His Glu Ala Lys Lys Asn 
65                  70                  75                  80  


Gly Leu Lys Gly Asp Ala Glu Asp Lys Tyr Ile Ser Glu Lys Leu Lys 
                85                  90                  95      


Glu Tyr His Ser Leu Leu Gln Phe Ile Asp Asp Val Leu Ser Val Lys 
            100                 105                 110         


Tyr Asn Glu Asn Arg Lys Ala Ile Lys Phe Pro Glu Tyr Leu Thr Arg 
        115                 120                 125             


Glu Met Ile Glu Ile Phe Leu Asn His Lys Phe Arg Lys Glu Val Thr 
    130                 135                 140                 


Tyr Thr Asn Lys Asn Gly Ala Ser Val Ser Phe Leu Leu Ser Thr Leu 
145                 150                 155                 160 


Ile Leu Asn Ala Ile Glu Lys His Ser Val Ile Glu Met Gln Pro Phe 
                165                 170                 175     


Val Asp Trp Arg Asn Trp Phe Val Glu Thr Lys Ser Lys Phe Leu Lys 
            180                 185                 190         


Lys Ser Ile Ile Asn Asn Cys Ile Pro Thr Asn Gly Gly Pro Ile Ser 
        195                 200                 205             


Arg Arg Arg Glu Thr Leu Met Lys Trp Arg Asp Asp Tyr Phe Thr Asn 
    210                 215                 220                 


Ala Glu Ile Asp Leu Ala Arg Leu His Lys Lys Phe Gly Thr Asp Thr 
225                 230                 235                 240 


Leu Met Ala Ser Leu Arg Glu Val Pro Gln Thr Glu Lys Ser Gly Asn 
                245                 250                 255     


Glu Tyr His Arg Leu Leu Lys Ser Cys Leu Gln Ser His Gln Lys Lys 
            260                 265                 270         


Leu Phe Gly Lys Arg Ala Glu Gly Tyr Asp Ile Asn Arg Ala Asp Asn 
        275                 280                 285             


Gln Leu Tyr Val Tyr Asn Thr Glu Val Val Lys Tyr Met Glu His Tyr 
    290                 295                 300                 


Phe Pro Val Lys Ser Ser Lys Arg Arg Asn Ser Thr Ala Glu Ile Lys 
305                 310                 315                 320 


Tyr Tyr Leu Gln Thr Asp Thr Ile Lys Cys Cys Leu His His Gln Ile 
                325                 330                 335     


Ile Asn Ala Val Arg Gly Leu Ala Leu Arg Glu Gly Lys Phe Asn Leu 
            340                 345                 350         


His Gly Phe Asp Asp Lys Leu Ile Pro Asn Glu Arg Asn Val Ser Ser 
        355                 360                 365             


Ser Ile Leu Asn Glu Leu Lys Thr Ser Glu Gly Phe Val Leu Asn Met 
    370                 375                 380                 


Leu Gly Gly Cys Ala Phe Ala Ala Asn Cys Leu Arg Asn Ile Val Asp 
385                 390                 395                 400 


Ala Thr Gln Arg Ser Asp Leu Leu Gly Phe Arg Cys Phe Glu Val Ser 
                405                 410                 415     


Leu Lys Lys Gly Lys Ser Asn Ser Asp Leu Phe Ala Leu Phe Phe Gly 
            420                 425                 430         


Phe Gly Arg Glu Asp Met Asp Asp Asp Ser Glu Trp Glu Lys His Leu 
        435                 440                 445             


Tyr Ala Ala Arg Tyr Ser Val Ser Glu Ile Arg Asn Arg Val Ala His 
    450                 455                 460                 


Tyr His Lys Ser Ala Ile Glu Asn Ile Tyr Asn Ile Thr Asp Phe Glu 
465                 470                 475                 480 


Tyr Arg Glu Asn Ser Met Cys Ser Tyr Thr Asp Thr Lys Phe Thr Thr 
                485                 490                 495     


Ala Leu Gln Asn Glu Ile Tyr Asn Thr Pro Lys Ala Phe Ser Leu Gln 
            500                 505                 510         


Leu Met Thr Gly Lys Val Leu Glu Tyr Tyr Pro Lys Glu Lys Leu Val 
        515                 520                 525             


Ser Phe Phe Gln Lys Tyr Lys Phe Ser Leu Tyr Arg Ser Val Val Pro 
    530                 535                 540                 


Phe Ala Pro Gly Phe Lys Asn Ile Met Arg Thr Gly Val Asn Tyr Gln 
545                 550                 555                 560 


Asn Ala Thr Gln Asn Arg Leu Phe Tyr Asp Met Gly Leu Thr Ala Phe 
                565                 570                 575     


Gln Asp Lys Asp Arg Tyr Ile Asp Asp Val Glu Ala Trp Asn Ala Arg 
            580                 585                 590         


Tyr Phe Phe Met Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Arg Phe 
        595                 600                 605             


Thr Asn Asp Lys Asn Asp Leu Phe Arg Lys Thr Val Glu Gln Val Leu 
    610                 615                 620                 


Glu Val Asn Arg Ser His Met Glu Lys Val Gly Lys Asp Asp Arg Gln 
625                 630                 635                 640 


Ala Phe Gly Glu Val Arg Gln Met Arg Glu Asn Glu Thr Ala Asn Asp 
                645                 650                 655     


Tyr Met Ala Tyr Leu Gln Ser Ser Leu Arg Met Glu Lys Asn Lys Lys 
            660                 665                 670         


Glu Leu Glu Gly Asn Gly Ala Lys Arg Ile Asn Phe Glu Lys Phe Ile 
        675                 680                 685             


Leu Gln Met Phe Val Lys Gly Phe Asp Ser Phe Leu Lys Asp Gly Ala 
    690                 695                 700                 


Phe Glu Phe Val His Ser Pro Glu Asn Cys Leu Thr Gly Ser Thr Glu 
705                 710                 715                 720 


Lys Glu Arg Ala Lys Glu Arg Asn Ser Leu Cys Glu Glu Ile Gly Asn 
                725                 730                 735     


Tyr Val Arg Leu Val Ser Thr Val Ile Asp Pro Gly Lys Gly Ser His 
            740                 745                 750         


Val Ala Phe Tyr Val Phe Cys Lys Met Leu Asn Ser Val Tyr Leu Ser 
        755                 760                 765             


Asn Ile Arg Asn Glu Met Ile Lys Tyr His Lys Val Val Arg Thr Asp 
    770                 775                 780                 


Glu Leu Ala His Leu Ile Glu Ile Ile Glu Leu Cys Leu Leu Ser Ala 
785                 790                 795                 800 


Asp Ala Val Ser Gln Lys Thr Val Asn Ala Asp Lys Leu Ser His Phe 
                805                 810                 815     


Phe Ala Glu Gly Val Asn Val Asp Asp Asp Glu Asn Val Ile His Ala 
            820                 825                 830         


Ser Met Glu Thr Phe Arg Lys Tyr Gly Thr Arg Asp Leu Phe His Lys 
        835                 840                 845             


Leu Met Leu Gln Asp Asp Arg Phe Leu Val Ser Ser Asp Asp Tyr Arg 
    850                 855                 860                 


Glu Trp Glu Glu Met Lys Glu Lys Ile Glu Gly Lys Val Lys Gln Arg 
865                 870                 875                 880 


Glu Leu Leu His Ala Glu Trp Cys Glu Ala Lys Glu Lys Asp Lys Lys 
                885                 890                 895     


Ser Arg Lys Val Lys Ser Asn Ser Arg Thr Cys Phe Glu Lys Lys Phe 
            900                 905                 910         


Met Gly Ala Lys Ala Glu Glu Tyr Tyr Ser Leu Cys Asn Val Ile Asp 
        915                 920                 925             


Lys Tyr Asn Trp Leu Asp Asn Lys Leu His Leu Val His Leu Asn Lys 
    930                 935                 940                 


Leu His Asn Leu Val Ile Glu Ile Leu Gly Arg Met Val Gly Phe Thr 
945                 950                 955                 960 


Ala Leu Phe Glu Arg Asp Phe Gln Tyr Ile Cys Lys Ser Asp Ser Glu 
                965                 970                 975     


Tyr Glu Gln Leu Tyr Asn Leu Asp Phe Asn Met Gly Leu Pro Lys Phe 
            980                 985                 990         


Lys Asn Ser Ile Lys Gly Ser Gly  Lys Ala Lys Asn Ser  Thr Gln Asn 
        995                 1000                 1005             


Ile Asp  His Asn Ala Thr Gly  Ile Gly Asn Ser Ser  Asn Leu Leu 
    1010                 1015                 1020             


Lys Glu  Asn Ser Asn Gly Thr  His Tyr Cys Lys Asn  Leu Ser Gly 
    1025                 1030                 1035             


Asp Gly  Val Glu Asp Lys Leu  Lys Arg Leu Phe Leu  Tyr Asp Asp 
    1040                 1045                 1050             


Tyr Arg  Asn Val Arg Asn Phe  Val Ala His Phe Asn  Tyr Leu Thr 
    1055                 1060                 1065             


Arg Val  Glu Asp Asp Leu Gly  Gly Asn Asp Ala Val  Lys Leu Ser 
    1070                 1075                 1080             


Gly Thr  Arg Tyr Ser Leu Ile  Glu Leu Ile Asn Glu  Leu Arg Asn 
    1085                 1090                 1095             


Leu Leu  Lys Tyr Asp Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ser 
    1100                 1105                 1110             


Phe Ile  Asp Met Phe Glu Arg  His Gly Met His Val  Lys Met Lys 
    1115                 1120                 1125             


Leu Asn  His Asn His Lys Leu  Phe Val Asp Ser Ile  Ser Pro Arg 
    1130                 1135                 1140             


Lys Ile  Lys His Leu Gly Gly  Gly Tyr Lys Lys Arg  Gly Lys Asp 
    1145                 1150                 1155             


Asp Lys  Met Tyr Val Gln Thr  Thr Asn His Val Asp  Pro Leu Tyr 
    1160                 1165                 1170             


Cys Asp  Met Cys Arg Ala Leu  Leu Glu Met Lys 
    1175                 1180                 


<210>  1242
<211>  1184
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1242

Met Arg Val Ser Lys Val Lys Val Leu Gly Asn Glu Glu Thr Lys Gly 
1               5                   10                  15      


Arg Ile Val Leu Met His Arg Ser Pro Val Lys Gly Gln Leu Ile Tyr 
            20                  25                  30          


Ser Glu Asp Ala Gly Lys Arg Asp Arg Thr Glu Asp Ile Ile Pro Glu 
        35                  40                  45              


Gln Lys Leu Glu Ser Phe His Leu Ser Ile Leu Asn Lys Thr Phe Leu 
    50                  55                  60                  


Arg Lys Glu Phe Phe Lys Lys Glu Leu Lys His Glu Ala Lys Lys Asn 
65                  70                  75                  80  


Gly Leu Lys Gly Asp Ala Glu Asp Lys Tyr Ile Ser Glu Lys Leu Lys 
                85                  90                  95      


Glu Tyr His Ser Leu Leu Gln Phe Ile Asp Asp Val Leu Ser Val Lys 
            100                 105                 110         


Tyr Asn Glu Asn Arg Lys Ala Ile Lys Phe Pro Glu Tyr Leu Thr Arg 
        115                 120                 125             


Glu Met Ile Glu Ile Phe Leu Asn His Lys Phe Arg Lys Glu Val Thr 
    130                 135                 140                 


Tyr Thr Asn Lys Asn Gly Ala Ser Val Ser Phe Leu Leu Ser Thr Leu 
145                 150                 155                 160 


Ile Leu Asn Ala Ile Glu Lys His Ser Val Ile Glu Met Gln Pro Phe 
                165                 170                 175     


Val Asp Trp Arg Asn Trp Phe Val Glu Thr Lys Ser Lys Phe Leu Lys 
            180                 185                 190         


Lys Ser Ile Ile Asn Asn Cys Ile Pro Thr Asn Gly Gly Pro Ile Ser 
        195                 200                 205             


Arg Arg Arg Glu Thr Leu Met Lys Trp Arg Asp Asp Tyr Phe Thr Asn 
    210                 215                 220                 


Ala Glu Ile Asp Leu Ala Arg Leu His Lys Lys Phe Gly Thr Asp Thr 
225                 230                 235                 240 


Leu Met Ala Ser Leu Arg Glu Val Pro Gln Thr Glu Lys Ser Gly Asn 
                245                 250                 255     


Glu Tyr His Arg Leu Leu Lys Ser Cys Leu Gln Ser His Gln Lys Lys 
            260                 265                 270         


Leu Phe Gly Lys Arg Ala Glu Gly Tyr Asp Ile Asn Arg Ala Asp Asn 
        275                 280                 285             


Gln Leu Tyr Val Tyr Asn Thr Glu Val Val Lys Tyr Met Glu His Tyr 
    290                 295                 300                 


Phe Pro Val Lys Ser Ser Lys Arg Arg Asn Ser Thr Ala Glu Ile Lys 
305                 310                 315                 320 


Tyr Tyr Leu Gln Thr Asp Thr Ile Lys Cys Cys Leu His His Gln Ile 
                325                 330                 335     


Ile Asn Ala Val Arg Gly Leu Ala Leu Arg Glu Gly Lys Phe Asn Leu 
            340                 345                 350         


His Gly Phe Asp Asp Lys Leu Ile Pro Asn Glu Arg Asn Val Ser Ser 
        355                 360                 365             


Ser Ile Leu Asn Glu Leu Lys Thr Ser Glu Gly Phe Val Leu Asn Met 
    370                 375                 380                 


Leu Gly Gly Cys Ala Phe Ala Ala Asn Cys Leu Arg Asn Ile Val Asp 
385                 390                 395                 400 


Ala Thr Gln Arg Ser Asp Leu Leu Gly Phe Arg Cys Phe Glu Val Ser 
                405                 410                 415     


Leu Lys Lys Gly Lys Ser Asn Ser Asp Leu Phe Ala Leu Phe Phe Gly 
            420                 425                 430         


Phe Gly Arg Glu Asp Met Asp Asp Asp Ser Glu Trp Glu Lys His Leu 
        435                 440                 445             


Tyr Ala Ala Arg Tyr Ser Val Ser Glu Ile Arg Asn Arg Val Ala His 
    450                 455                 460                 


Tyr His Lys Ser Ala Ile Glu Asn Ile Tyr Asn Ile Thr Asp Phe Lys 
465                 470                 475                 480 


Tyr Arg Glu Asn Ser Met Cys Ser Tyr Thr Asp Thr Lys Phe Thr Thr 
                485                 490                 495     


Ala Leu Gln Asn Glu Ile Tyr Asn Thr Pro Lys Ala Leu Ser Leu Gln 
            500                 505                 510         


Leu Met Thr Gly Lys Val Leu Glu Tyr Tyr Pro Lys Glu Lys Leu Val 
        515                 520                 525             


Ser Phe Phe Gln Lys Tyr Lys Phe Ser Leu Tyr Arg Ser Val Val Pro 
    530                 535                 540                 


Phe Ala Pro Gly Phe Lys Asn Ile Met Arg Thr Gly Val Asn Tyr Gln 
545                 550                 555                 560 


Asn Ala Thr Gln Asn Ser Leu Phe Tyr Asp Met Gly Leu Thr Ala Phe 
                565                 570                 575     


Gln Asp Lys Asp Arg Tyr Ile Asp Asp Val Glu Ala Trp Asn Ala Arg 
            580                 585                 590         


Tyr Phe Phe Met Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Arg Phe 
        595                 600                 605             


Thr Asn Asp Lys Asn Asp Leu Phe Arg Lys Thr Val Glu Gln Val Leu 
    610                 615                 620                 


Glu Val Asn Arg Ser His Met Glu Lys Val Gly Lys Asp Asp Arg Gln 
625                 630                 635                 640 


Ala Phe Gly Glu Val Arg Gln Met Arg Glu Asn Glu Thr Ala Asn Asp 
                645                 650                 655     


Tyr Met Ala Tyr Leu Gln Ser Ser Leu Arg Met Glu Lys Asn Lys Lys 
            660                 665                 670         


Glu Leu Glu Gly Asn Gly Ala Lys Arg Ile Asn Phe Glu Lys Phe Ile 
        675                 680                 685             


Leu Gln Met Phe Val Lys Gly Phe Asp Ser Phe Leu Lys Asp Gly Ala 
    690                 695                 700                 


Phe Glu Phe Val His Ser Pro Glu Asn Cys Leu Thr Gly Ser Thr Glu 
705                 710                 715                 720 


Lys Glu Arg Ala Lys Glu Arg Asn Ser Leu Cys Glu Glu Ile Gly Asn 
                725                 730                 735     


Tyr Val Arg Leu Val Ser Thr Val Ile Asp Pro Gly Lys Gly Ser His 
            740                 745                 750         


Val Ala Phe Tyr Val Phe Cys Lys Met Leu Asn Ser Val Tyr Leu Ser 
        755                 760                 765             


Asn Ile Arg Asn Glu Met Ile Lys Tyr His Lys Val Val Arg Thr Asp 
    770                 775                 780                 


Glu Leu Ala His Leu Ile Glu Ile Ile Glu Leu Cys Leu Leu Ser Ala 
785                 790                 795                 800 


Asp Ala Val Ser Gln Lys Thr Val Asn Ala Asp Lys Leu Ser His Phe 
                805                 810                 815     


Phe Ala Glu Gly Val Asn Val Asp Asp Asp Glu Asn Val Ile His Ala 
            820                 825                 830         


Ser Met Glu Thr Phe Arg Lys Tyr Gly Thr Arg Asp Leu Phe His Lys 
        835                 840                 845             


Leu Met Leu Gln Asp Asp Arg Phe Leu Val Ser Ser Asp Asp Tyr Arg 
    850                 855                 860                 


Glu Trp Glu Glu Met Lys Glu Lys Ile Glu Gly Lys Val Lys Gln Arg 
865                 870                 875                 880 


Glu Leu Leu His Ala Glu Trp Cys Glu Ala Lys Glu Lys Asp Lys Lys 
                885                 890                 895     


Ser Arg Lys Val Lys Ser Asn Ser Arg Thr Cys Phe Glu Lys Lys Phe 
            900                 905                 910         


Met Gly Ala Lys Ala Glu Glu Tyr Tyr Ser Leu Cys Lys Val Ile Asp 
        915                 920                 925             


Lys Tyr Asn Trp Leu Asp Asn Lys Leu His Leu Val His Leu Asn Lys 
    930                 935                 940                 


Leu His Asn Leu Val Ile Glu Ile Leu Gly Arg Met Val Gly Phe Thr 
945                 950                 955                 960 


Ala Leu Phe Glu Arg Asp Phe Gln Tyr Ile Cys Lys Ser Asp Ser Glu 
                965                 970                 975     


Tyr Glu Gln Leu Tyr Asn Leu Asp Phe Asn Met Gly Leu Pro Lys Phe 
            980                 985                 990         


Lys Asn Ser Ile Lys Gly Ser Gly  Lys Ala Lys Asn Ser  Thr Gln Asn 
        995                 1000                 1005             


Ile Asp  His Asn Ala Thr Gly  Ile Gly Asn Ser Ser  Asn Leu Leu 
    1010                 1015                 1020             


Lys Glu  Asn Ser Asn Gly Thr  His Tyr Cys Lys Asn  Leu Ser Gly 
    1025                 1030                 1035             


Asp Gly  Val Glu Asp Lys Leu  Lys Arg Leu Phe Leu  Tyr Asp Asp 
    1040                 1045                 1050             


Tyr Arg  Asn Val Arg Asn Phe  Val Ala His Phe Asn  Tyr Leu Thr 
    1055                 1060                 1065             


Arg Val  Glu Asp Asp Leu Gly  Gly Asn Asp Ala Val  Lys Leu Ser 
    1070                 1075                 1080             


Gly Thr  Arg Tyr Ser Leu Ile  Glu Leu Ile Asn Glu  Leu Arg Asn 
    1085                 1090                 1095             


Leu Leu  Lys Tyr Asp Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ser 
    1100                 1105                 1110             


Phe Ile  Asp Met Phe Glu Arg  His Gly Met His Val  Lys Met Lys 
    1115                 1120                 1125             


Leu Asn  His Asn His Lys Leu  Phe Val Asp Ser Ile  Ser Pro Arg 
    1130                 1135                 1140             


Lys Ile  Lys His Leu Gly Gly  Gly Tyr Lys Lys Arg  Gly Lys Asp 
    1145                 1150                 1155             


Asp Lys  Met Tyr Val Gln Thr  Thr Asn His Val Asp  Pro Leu Tyr 
    1160                 1165                 1170             


Cys Asp  Met Cys Arg Ala Leu  Leu Glu Met Lys 
    1175                 1180                 


<210>  1243
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1243

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Gly Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  1244
<211>  946
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1244

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Asp Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn Tyr Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Gly Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Gly Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Lys Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Arg Phe 
    930                 935                 940                 


Tyr Gln 
945     


<210>  1245
<211>  1268
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1245

Met Lys Val Ser Lys Val Asn His Arg Arg Ala Ala Val Ala Val Asn 
1               5                   10                  15      


Lys Lys Ser Val Thr Val Asn Gly Ile Leu Tyr Asp Ala Pro Val Lys 
            20                  25                  30          


Lys Asn Val Lys Thr Gly Asn Met Ser Ala Tyr Val Ser Ser Lys Tyr 
        35                  40                  45              


Val Ile Asp Asn Val Val Lys Asn Ser Ser Arg Leu Tyr Ser Pro Phe 
    50                  55                  60                  


Ser Ser Lys Arg Ile Val Ile Asp Arg Glu Lys Ile Arg Ile Ala Asp 
65                  70                  75                  80  


Arg Leu Lys Gln Cys Tyr Val Asn Phe Val Lys Tyr Tyr Leu Ser Asn 
                85                  90                  95      


Gly Ser Leu Asn Glu Gln Gln Met Arg Phe Asn Pro Asn Asn Thr Tyr 
            100                 105                 110         


Met Thr Asp Ser Arg Val His Phe Cys Ala Pro Ser Gly Ile Asp Lys 
        115                 120                 125             


Glu Ser Leu Ile Asn Ser Ile Val Asp Ser Ser Leu Arg Lys Ser Leu 
    130                 135                 140                 


Lys Arg Thr Tyr Arg Phe Glu Thr Asn Tyr Gly Glu Lys Ile Thr Phe 
145                 150                 155                 160 


Asn Leu Pro Asp Leu Val Lys Lys Ser Ile Lys Ile Tyr Cys Thr Asp 
                165                 170                 175     


Glu Lys Arg Lys Leu Asn Asp Arg Glu Glu Gln Glu Met Tyr Val Leu 
            180                 185                 190         


Phe Ser Tyr Met Tyr Glu Asp Lys Tyr Lys Asp Arg Gln Lys Val Leu 
        195                 200                 205             


Ile Ala Asn Ser Ile Ser Asn Gln Ala Thr Lys Val Lys Val Cys Asp 
    210                 215                 220                 


Asp Glu Ser Arg Leu Ile Lys Leu Ser Ile Ala Asp Thr Lys Lys Lys 
225                 230                 235                 240 


Pro Leu Trp Asp Phe Ile Val Asp Tyr Ala Asn Ser Asp Lys Asn Gly 
                245                 250                 255     


Gln Tyr Thr Ile Leu Arg Asn Ile Arg Lys Ser Ile Val Leu Phe Val 
            260                 265                 270         


Cys Gly Val Asp Val Tyr Arg Asn Ile Glu Asn Asn Asp Asn Leu Asp 
        275                 280                 285             


Ile Trp Lys Trp Glu Glu Tyr Gly Ile Gln Glu Ser Gln Leu Phe Val 
    290                 295                 300                 


Lys Ile Glu Asn Cys Tyr Thr Thr Lys Asp Glu Asp Ile Ala Leu Asn 
305                 310                 315                 320 


Glu Ile Arg Asn Val Asn Leu Asp His Tyr Met Lys Ala Ile Gly Val 
                325                 330                 335     


Leu Asp Asp Glu Arg Ser Lys Phe Trp Phe Gln His Tyr Glu Asn Thr 
            340                 345                 350         


Ile Glu Ala Leu Phe Ser Lys Lys Ser Lys Arg Lys Ile Glu Arg Ile 
        355                 360                 365             


Lys Thr Ala Tyr Leu Cys Glu Tyr Leu Trp Lys Asn Phe Cys Ser Tyr 
    370                 375                 380                 


Val Ala Leu Lys Tyr Val Asp Leu Gly Lys Gly Val Tyr His Phe Thr 
385                 390                 395                 400 


Met Ser Asp Lys Leu Ser Leu Met Asn Lys Asn Thr Asn Glu Asn Gly 
                405                 410                 415     


Ile Lys Phe Gly Glu Val Asp Ser Arg Phe Asn Lys Gly Ile Ser Ser 
            420                 425                 430         


Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu Thr Ile Asp Arg Asn Ile 
        435                 440                 445             


Ser Thr Tyr Thr Thr Phe Ala Thr Asn Ile Phe Ala Lys Ser Val Ile 
    450                 455                 460                 


Lys Asp Ser Tyr Ile Gln Lys Lys Ala Gly Asn Ser Asp Ala Leu Gln 
465                 470                 475                 480 


Tyr Asp Asp Glu Thr Tyr Tyr Asn Arg Lys Ala Met Asn Pro Asp Ala 
                485                 490                 495     


Leu Lys Arg Val Leu Gln Tyr Trp Gly Gly Gln Ser Arg Trp Lys Ser 
            500                 505                 510         


Glu Leu Glu Glu Leu Asn Val Ala Glu Leu Cys Ile Asp Ile Lys Asn 
        515                 520                 525             


Arg Leu Ser Lys Ile Arg Asn Ser Gly Val His Tyr Thr Ser Thr Ser 
    530                 535                 540                 


Thr Leu Lys Gly Asn Asp Asp Asp Ser Ile Val Gly Met Leu Ile Lys 
545                 550                 555                 560 


Lys Asp Phe Asp Asp Ile Lys Asp Val Tyr Ala Ser Lys Tyr Tyr Ser 
                565                 570                 575     


Asn Asn Val Trp Ile Phe Tyr Asn Thr Asp Lys Ile Ser Lys Met Met 
            580                 585                 590         


Glu Tyr Leu Tyr Gln Asp Asp Ser Asn Ile Arg Asp Ala Gln Ile Pro 
        595                 600                 605             


Ala Phe Asn Ser Val Ile Lys Arg Lys Asp Met Ala Glu Val Ile Glu 
    610                 615                 620                 


Lys Ile Ile Lys Lys Asn Ser Tyr Lys Thr Ile Lys Glu Pro Tyr Gln 
625                 630                 635                 640 


Arg Glu Lys Tyr Arg Ser Cys Leu Tyr Phe Met Leu Lys Glu Ile Tyr 
                645                 650                 655     


Tyr Asn Arg Phe Ile Lys Gln Asp Asp Leu Lys Asp Gln Val Ile Gln 
            660                 665                 670         


Ile Ile Asp Ser Asn Thr Glu Leu Ile Gly Asp Asn Ser Arg Ala Val 
        675                 680                 685             


Asp Asn Leu Lys Lys Arg Ile His Asp Val Asp Ser Gln Thr Met Ser 
    690                 695                 700                 


Phe Gly Glu Leu Cys Gln Val Ile Met Thr Asp Tyr Asn Met Gln Asn 
705                 710                 715                 720 


Gln Glu Asn Lys Ser Ile Lys Ser Lys Glu Arg Gln Asp Lys Asp Arg 
                725                 730                 735     


Lys Asn Gly Ile Asp Asn Ser Tyr Lys His Phe Pro Leu Leu Leu His 
            740                 745                 750         


His Leu Ile Lys Val Ser Phe Leu Lys Phe Ile Lys Thr Asp Glu Lys 
        755                 760                 765             


Leu Ala Phe Ile Arg Glu Pro Arg Ile Thr Glu Tyr Asp Lys Thr Leu 
    770                 775                 780                 


Glu Gln Phe Glu Ala Gln Ile Gln Thr Val Asp Ile Tyr Asn Ser Leu 
785                 790                 795                 800 


Lys Val Met Val Ala Glu Asn Lys Ser Leu Leu Asp Trp Tyr Thr Leu 
                805                 810                 815     


Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile Gly Asp Ile 
            820                 825                 830         


Lys Asn Tyr Ile Gln Tyr Leu Ser Asn Ile Asp Lys Arg Ala Gly Ser 
        835                 840                 845             


Val Lys Asn Asn Lys Cys Ala Ser Thr Glu Val Lys Ile Arg Gln Tyr 
    850                 855                 860                 


Ser Glu Ile Val Arg Ile Leu Asp Phe Ser Leu Gln Tyr Ile Gly Arg 
865                 870                 875                 880 


Val Ser Asn Asp Val Thr Asp Tyr Phe Val Asp Glu Asp Glu Tyr Ala 
                885                 890                 895     


Ala Phe Leu Ser Lys Tyr Val Glu Phe Ser Gly Asn Asp Thr Val Ser 
            900                 905                 910         


Met Lys Ala Phe Cys Gln Ser Arg Thr Ala Asn Gly Lys His Thr Ile 
        915                 920                 925             


Gly Leu Tyr Cys Asp Gly Ala Asn Pro Ile Met Asn Arg Asn Ile Ala 
    930                 935                 940                 


Tyr Ala Lys Met Tyr Gly Asn Asp Glu Ile Leu Ser Tyr Ile Tyr Asn 
945                 950                 955                 960 


Lys Val Thr Lys Lys Asp Ile Glu Lys Tyr Tyr Val Ser Gln Asp Asn 
                965                 970                 975     


Leu Glu Lys Val Phe Ala Asp Gly Lys Cys Gln Asp Val Gln Gln Gln 
            980                 985                 990         


Asn Ala Leu Cys Asp Phe Gln Lys  Met Lys Asn His Ile  Glu Leu Thr 
        995                 1000                 1005             


Glu Val  Ser Ile Tyr Thr Asp  Ile Leu Asn Asp Phe  Met Ala Gln 
    1010                 1015                 1020             


Phe Ile  Ser Trp Ala Tyr Leu  Arg Glu Arg Asp Leu  Met Tyr Phe 
    1025                 1030                 1035             


Gln Leu  Gly Leu Asn Tyr Ile  Arg Met Phe Tyr Gly  Thr Tyr Glu 
    1040                 1045                 1050             


Leu Glu  Glu Lys Tyr Asn Lys  Leu His Gly Glu Asn  Ile Asn Ile 
    1055                 1060                 1065             


Glu Lys  Gly Ala Leu Leu Tyr  Gln Ile Val Ala Met  Tyr Ser His 
    1070                 1075                 1080             


Glu Leu  Pro Ile Tyr Lys Val  Asp Glu Ser Asp Ile  Ala Ile Leu 
    1085                 1090                 1095             


Ala Glu  Lys Gln Gly Ser Ser  Gly Ala Ser Ile Lys  Ser Phe Val 
    1100                 1105                 1110             


Thr Glu  Tyr Cys Lys Glu Glu  Met Lys Lys Ala Tyr  Thr Tyr Glu 
    1115                 1120                 1125             


Asn Gly  Leu Glu Phe Phe Glu  Asp Val Asn Gln His  Asp Asn Leu 
    1130                 1135                 1140             


Ser Lys  Leu Arg Asn Asp Phe  Ala His Met Arg Tyr  Met Ser Ala 
    1145                 1150                 1155             


Arg Asp  Lys Ser Ile Met Asp  Ile Val Ser Glu Ile  Tyr Asn Gly 
    1160                 1165                 1170             


Phe Phe  Ile Tyr Asp Thr Lys  Leu Lys Lys Ser Val  Ser Phe Ile 
    1175                 1180                 1185             


Phe Lys  Asn Ile Leu Met Arg  Tyr Ala Val Asp Val  Asn Ile Glu 
    1190                 1195                 1200             


Phe Cys  His Lys Gly Asp Asn  Glu Asp Thr Asn Asn  Leu Ile Arg 
    1205                 1210                 1215             


Ile Lys  Asp Glu Val Gly Leu  Tyr Ser Asp Lys Tyr  Thr Tyr Lys 
    1220                 1225                 1230             


Val Glu  Asp Asn Asp Thr Val  Asp Ile Glu Val Arg  Asn Ser Glu 
    1235                 1240                 1245             


Phe Leu  Glu Gln Leu Lys Lys  Leu Leu Glu Tyr Lys  Lys Glu Ser 
    1250                 1255                 1260             


Lys Gly  Ser Glu Leu 
    1265             


<210>  1246
<211>  1265
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1246

Met Arg Ile Ile Lys Pro Tyr Gly Arg Ser Val Ile Ala Lys Glu Ser 
1               5                   10                  15      


Leu Ala Glu Arg Lys Ile Asp Leu Gly Gly Glu Pro Ser Gly Ser Lys 
            20                  25                  30          


Leu Lys Ile Tyr Ser Val Lys Glu Leu Ala Asp Asn Asp Lys Leu Val 
        35                  40                  45              


Met Ala Tyr Trp Ile Ser Val Ile Asp Arg Ile Ile Cys Lys Pro Ile 
    50                  55                  60                  


Glu Pro Arg Lys Lys Gln Thr Glu Lys Glu Lys Gln Ala Asn Gln Gly 
65                  70                  75                  80  


Ala Ala Ala Ser Arg Ala Ala Ile Gly Asp Ala Ala Trp Glu Ile Leu 
                85                  90                  95      


Gln Thr Glu Leu Ser Ala Phe Gln Ala Asn Ser Arg Tyr Lys Thr Ala 
            100                 105                 110         


Lys Glu Arg Thr Asn Asp Gln Glu Lys Leu Arg Asp Ile Trp Gln Gln 
        115                 120                 125             


Lys Ile Ala Ala Leu Ser Ser Ala Lys Lys Gln Ser Asn Phe Phe Pro 
    130                 135                 140                 


Arg Gly Arg Trp Tyr Asp Ile Phe Ala Lys Asp Cys Asn Pro Phe Lys 
145                 150                 155                 160 


Ile Ser Gln Gly Glu Ala Asp Arg Ile Ala Asp Lys Ile Ser Lys His 
                165                 170                 175     


Leu Tyr Gln Lys Ala Tyr Lys Tyr Asn Lys Ser Ser Gln Pro Val His 
            180                 185                 190         


Gln Lys Pro Gly Ala Asp Lys Arg Arg Lys Ser Cys Gly Val Leu Asn 
        195                 200                 205             


Asp Thr Leu Lys Ser Ile Ala Val Asn Ser Leu Leu Asn Ala Glu Met 
    210                 215                 220                 


His Arg Arg Arg Leu Met Pro Ile Gly Glu Asn Ile Trp Gln Glu Tyr 
225                 230                 235                 240 


Cys Ser Lys Ala Gly Glu Phe Ala Ala Glu Ile Arg Asn Asn Ile Leu 
                245                 250                 255     


Ala Ala His Asp Ser Asp Asp Lys Thr Lys Pro Tyr His Leu Ser Val 
            260                 265                 270         


Met Ala Leu Arg Asp Ile Val Trp Pro Lys Val Phe Asp Lys Ala Ser 
        275                 280                 285             


Asp Tyr Asn Ser Ala Val Lys Gly Lys Asn Lys His Leu Leu Pro Ile 
    290                 295                 300                 


His Lys Ala Val Lys Gln Val Tyr Lys Thr Ile Leu Lys Glu Ala Val 
305                 310                 315                 320 


Leu Leu His Glu Lys Gln Lys Glu Thr Phe Pro Lys Gly Ser Ala Gly 
                325                 330                 335     


Arg Asp Ala Met Leu Ala Glu Arg Arg Ala Lys Leu Ala Gly Ile Leu 
            340                 345                 350         


Pro Ala Ser Asn Glu Ala Phe Tyr Ala Leu Leu Lys Asn Lys Gln Arg 
        355                 360                 365             


Asn Ser Glu Val Asn Ser Leu Ile Arg Leu Gly Lys Val Ile His Tyr 
    370                 375                 380                 


Thr Ala Ser Lys Asn Lys Glu Tyr Asp Glu Thr Asn Ser Ile Asn Asn 
385                 390                 395                 400 


Phe Pro Asp Lys Glu Ala Ile Glu Asn Ser Pro Tyr Trp Ser Ser Gln 
                405                 410                 415     


Gly Gln Thr Glu Ile Lys Gln Asn Glu Ala Phe Val Arg Val Trp Arg 
            420                 425                 430         


Arg Ala Leu Val Phe Ala Ala His Asn Leu Lys Asn Trp Val Asp Pro 
        435                 440                 445             


Lys Gly Glu Leu Arg Asp Lys Glu Asp Arg Glu Ala Asp Ile Leu Phe 
    450                 455                 460                 


Ser Asn Phe Ala Tyr Pro Glu Lys Leu Gly Tyr Gln Asp Ile Ala Gln 
465                 470                 475                 480 


Ser Gly Arg Ser His Leu Glu Gln Lys Phe Ala Leu Ser Phe Gly Asp 
                485                 490                 495     


Ser Gly Ile Ala Ala Lys Asn Ala Ala Pro Val Glu Asn Arg Gln Ile 
            500                 505                 510         


Leu Leu Leu Ala Trp Ser Gly Leu Lys Ala Leu Arg Asn Ser Ala Phe 
        515                 520                 525             


His Phe Lys Gly Met Gly Ser Phe Val Asn Gly Ile Lys Gly Leu Ala 
    530                 535                 540                 


Gly Thr Ala Pro Gly Ala Ala Glu Phe Ala Arg Glu Leu Tyr Asn Ile 
545                 550                 555                 560 


Asp Cys Gly Lys Arg Gln Glu Arg Leu Lys Ala Val Met Gln Ala Ala 
                565                 570                 575     


Tyr Phe His Leu Tyr Phe Gly Ile Ser Gln Ile Glu Thr Ile Trp Gln 
            580                 585                 590         


Ala Ser Ala Leu Leu Ser Ala Glu Ile Leu Pro Leu Pro Lys Leu Lys 
        595                 600                 605             


Ser Val Leu Glu Arg Ala Gln Lys Ala Trp Asn Arg Asn Ile Lys Pro 
    610                 615                 620                 


Gln Thr Asp Glu Lys Leu Ser Leu Ile Leu Pro Pro Tyr Ser Thr Pro 
625                 630                 635                 640 


Gln Glu Arg Glu Ala Asp Glu Trp Ala Leu Cys Gln Tyr Asn Ala Ala 
                645                 650                 655     


Lys Ile Leu Tyr Glu Asn Gly Phe Lys Thr Trp Leu Gln Asn Leu Ser 
            660                 665                 670         


Lys Asn Gly Ser Ala Glu Leu Arg Arg Tyr Ile Glu Thr Ala Leu Ala 
        675                 680                 685             


Asn Thr Thr Ser Ala Ala Arg Ser Met Asn Ala Lys Lys Asp Glu Asp 
    690                 695                 700                 


Gly Glu Phe Val Val Ala Lys Ala Glu Lys Val Leu Ala Ala Leu Pro 
705                 710                 715                 720 


Gln Ser Gly Thr Met Glu Lys Phe Phe Ala Gly Leu Met Ser Glu Ile 
                725                 730                 735     


Thr Ala Glu Gly Arg Ile Gln Lys Gln Val Tyr Arg Asn Asp Pro Glu 
            740                 745                 750         


Lys Ala Gln Gly Phe Ser Ala Tyr Leu Glu Asn Leu Lys Cys Asp Val 
        755                 760                 765             


Ile Ala Gln Ala Phe Ser Asp Tyr Leu Ser Gly Ile Ile Asp Lys Lys 
    770                 775                 780                 


Asp Leu Phe Cys Ala Arg Glu Arg Lys Ala Ser Glu Val Gln Ala Gly 
785                 790                 795                 800 


Asn Val Phe Ser Arg Leu Ser Pro Val Lys Leu Lys Lys Pro Glu Glu 
                805                 810                 815     


Glu Trp Glu Gly Ile Leu Tyr Phe Leu Leu His Phe Met Pro Val Glu 
            820                 825                 830         


Glu Ala Gly Gly Leu Arg Gln Gln Leu Lys Lys Trp Glu Leu Ala Val 
        835                 840                 845             


Asp Ala Gly Glu Thr Lys Gly Gln Arg Glu Asp Glu Arg Lys Leu Ala 
    850                 855                 860                 


Gln Ser Val Leu Lys Ala Phe Asp Leu Tyr Ile Ala Met His Asp Ala 
865                 870                 875                 880 


Gln Phe Leu Glu Thr Lys Asp Asp Ser Leu Ala Glu Lys Leu Gly Ser 
                885                 890                 895     


Ala Gln Gly Lys Ala Ala Glu Ile Leu Ser Glu Thr Tyr Gly Asp Phe 
            900                 905                 910         


Tyr Glu Gly Gly Glu Ala Asp Phe Cys Lys Ile Phe Met Pro Ala Gly 
        915                 920                 925             


Gly Gln Lys Gly Ile Gly Thr Asp Pro Leu Leu Arg Glu Leu Arg Glu 
    930                 935                 940                 


Met Gln Arg Phe Gly Ser Arg Gly Leu Asn Glu Leu Phe Arg Lys Leu 
945                 950                 955                 960 


Gly Pro Glu Ile Lys Lys Ser Gln Val Ala Ala Trp Leu Asp Glu Glu 
                965                 970                 975     


Arg Ala Arg Arg Asp Gly Gln Gly Ile Ala Gln Ile Gln Lys Glu Lys 
            980                 985                 990         


Ile Glu Leu His Glu Gln Trp Ile  Asp Asn Pro Lys Ser  Lys Asp Trp 
        995                 1000                 1005             


Phe Trp  Phe Asp Ala Val Lys  Lys Gln Trp Arg Leu  Gly Val Lys 
    1010                 1015                 1020             


Ala Lys  Gln Tyr Gln Leu Leu  Val Asn Lys Val Thr  Arg His Arg 
    1025                 1030                 1035             


Gln Leu  Thr Ala Gln Val Thr  Leu Gln Asn Tyr Leu  Arg Leu His 
    1040                 1045                 1050             


Arg Leu  Ile Met Ala Val Leu  Gly Arg Leu Val Asp  Phe Ser Arg 
    1055                 1060                 1065             


Leu Trp  Glu Arg Asp Leu Tyr  Phe Val Leu Leu Ala  Arg Leu Tyr 
    1070                 1075                 1080             


Glu Lys  Gln Gln Glu Gly Glu  Val Lys Lys Gln Gly  Tyr Leu Lys 
    1085                 1090                 1095             


Ser Gln  Phe Arg Leu Lys Lys  Asp Gly Leu Met Lys  Asp Gly Ile 
    1100                 1105                 1110             


Tyr Phe  Leu Arg Ser Gly Gln  Ile Val Glu Ala Val  Lys Ala Leu 
    1115                 1120                 1125             


Lys Asp  Glu Met Leu Arg Gly  Glu Ile Asn Ser Val  Phe Gly Ile 
    1130                 1135                 1140             


Gly Glu  Asn Asp Asn Ser Gln  Ile Phe Leu Arg Asn  Tyr Phe Ala 
    1145                 1150                 1155             


His Leu  Ala Met Leu Ser Asn  Glu Lys Ile Ala Glu  Glu Gly Ile 
    1160                 1165                 1170             


Asp Leu  Thr Gln Ala Val Asn  Lys Ala Arg Arg Leu  Met Ala Tyr 
    1175                 1180                 1185             


Asp Arg  Lys Leu Lys Asn Ala  Val Ser Lys Ala Val  Leu Asp Leu 
    1190                 1195                 1200             


Leu Glu  Arg Glu Lys Ile Lys  Leu Gln Trp Met Lys  Val Glu Lys 
    1205                 1210                 1215             


Thr Ala  Arg Gly His Asp Leu  Ala Gln Ala Asp Ile  His Ser Asp 
    1220                 1225                 1230             


Phe Ala  Tyr His Leu Lys Lys  Ser Lys Thr Asp Lys  Ser Gln Ile 
    1235                 1240                 1245             


Lys Glu  Pro Ile Tyr Gly Asp  Asp Tyr Ile His Met  Leu Lys Ser 
    1250                 1255                 1260             


Leu Phe  
    1265 


<210>  1247
<211>  1184
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1247

Met Arg Val Ser Lys Val Lys Val Leu Gly Asn Glu Glu Thr Lys Gly 
1               5                   10                  15      


Arg Ile Val Leu Met His Arg Ser Pro Val Lys Gly Gln Leu Ile Tyr 
            20                  25                  30          


Ser Glu Asp Ala Gly Lys Arg Asp Arg Thr Glu Asp Ile Ile Pro Glu 
        35                  40                  45              


Gln Lys Leu Glu Ser Phe His Leu Ser Ile Leu Asn Lys Thr Phe Leu 
    50                  55                  60                  


Arg Lys Glu Phe Phe Lys Lys Glu Leu Lys His Glu Ala Lys Lys Asn 
65                  70                  75                  80  


Gly Leu Lys Gly Asp Ala Glu Asp Lys Tyr Ile Ser Glu Lys Leu Lys 
                85                  90                  95      


Glu Tyr His Ser Leu Leu Gln Phe Ile Asp Asp Val Leu Ser Val Lys 
            100                 105                 110         


Tyr Asn Glu Asn Arg Lys Ala Ile Lys Phe Pro Glu Tyr Leu Thr Arg 
        115                 120                 125             


Glu Met Ile Glu Ile Phe Leu Asn His Lys Phe Arg Lys Glu Val Thr 
    130                 135                 140                 


Tyr Thr Asn Lys Asn Gly Ala Ser Val Ser Phe Leu Leu Ser Thr Leu 
145                 150                 155                 160 


Ile Leu Asn Ala Ile Glu Lys His Ser Val Ile Glu Met Gln Pro Phe 
                165                 170                 175     


Val Asp Trp Arg Asn Trp Phe Val Glu Thr Lys Ser Lys Phe Leu Lys 
            180                 185                 190         


Lys Ser Ile Ile Asn Asn Cys Ile Pro Thr Asn Gly Gly Pro Ile Ser 
        195                 200                 205             


Arg Arg Arg Glu Thr Leu Met Lys Trp Arg Asp Asp Tyr Phe Thr Asn 
    210                 215                 220                 


Ala Glu Ile Asp Leu Ala Arg Leu His Lys Lys Phe Gly Thr Asp Thr 
225                 230                 235                 240 


Leu Met Ala Ser Leu Arg Glu Val Pro Gln Thr Glu Lys Ser Gly Asn 
                245                 250                 255     


Glu Tyr His Arg Leu Leu Lys Ser Cys Leu Gln Ser His Gln Lys Lys 
            260                 265                 270         


Leu Phe Gly Lys Arg Ala Glu Gly Tyr Asp Ile Asn Arg Ala Asp Asn 
        275                 280                 285             


Gln Leu Tyr Val Tyr Asn Thr Glu Val Val Lys Tyr Met Glu His Tyr 
    290                 295                 300                 


Phe Pro Val Lys Ser Ser Lys Arg Arg Asn Ser Thr Ala Glu Ile Lys 
305                 310                 315                 320 


Tyr Tyr Leu Gln Thr Asp Thr Ile Lys Cys Cys Leu His His Gln Ile 
                325                 330                 335     


Ile Asn Ala Val Arg Gly Leu Ala Leu Arg Glu Gly Lys Phe Asn Leu 
            340                 345                 350         


His Gly Phe Asp Asp Lys Leu Ile Pro Asn Glu Arg Asn Val Ser Ser 
        355                 360                 365             


Ser Ile Leu Asn Glu Leu Lys Thr Ser Glu Gly Phe Val Leu Asn Met 
    370                 375                 380                 


Leu Gly Gly Cys Ala Phe Ala Ala Asn Cys Leu Arg Asn Ile Val Asp 
385                 390                 395                 400 


Ala Thr Gln Arg Ser Asp Leu Leu Gly Phe Arg Cys Phe Glu Val Ser 
                405                 410                 415     


Leu Lys Lys Gly Lys Ser Asn Ser Asp Leu Phe Ala Leu Phe Phe Gly 
            420                 425                 430         


Phe Gly Arg Glu Asp Met Asp Asp Asp Ser Glu Trp Glu Lys His Leu 
        435                 440                 445             


Tyr Ala Ala Arg Tyr Ser Val Ser Glu Ile Arg Asn Arg Val Ala His 
    450                 455                 460                 


Tyr His Lys Ser Ala Ile Glu Asn Ile Tyr Asn Ile Thr Asp Phe Glu 
465                 470                 475                 480 


Tyr Arg Glu Asn Ser Met Cys Ser Tyr Thr Asp Thr Lys Phe Thr Thr 
                485                 490                 495     


Ala Leu Gln Asn Glu Ile Tyr Asn Thr Pro Lys Ala Phe Ser Leu Gln 
            500                 505                 510         


Leu Met Thr Gly Lys Val Leu Glu Tyr Tyr Pro Lys Glu Lys Leu Val 
        515                 520                 525             


Ser Phe Phe Gln Lys Tyr Lys Phe Ser Leu Tyr Arg Ser Val Val Pro 
    530                 535                 540                 


Phe Ala Pro Gly Phe Lys Asn Ile Met Arg Thr Gly Val Asn Tyr Gln 
545                 550                 555                 560 


Asn Ala Thr Gln Asn Arg Leu Phe Tyr Asp Met Gly Leu Thr Ala Phe 
                565                 570                 575     


Gln Asp Lys Asp Arg Tyr Ile Asp Asp Val Glu Ala Trp Asn Ala Arg 
            580                 585                 590         


Tyr Phe Phe Met Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Arg Phe 
        595                 600                 605             


Thr Asn Asp Lys Asn Asp Leu Phe Arg Lys Thr Val Glu Gln Val Leu 
    610                 615                 620                 


Glu Val Asn Arg Ser His Met Glu Lys Val Gly Lys Asp Asp Arg Gln 
625                 630                 635                 640 


Ala Phe Gly Glu Val Arg Gln Met Arg Glu Asn Glu Thr Ala Asn Asp 
                645                 650                 655     


Tyr Met Ala Tyr Leu Gln Ser Ser Leu Arg Met Glu Lys Asn Lys Lys 
            660                 665                 670         


Glu Leu Glu Gly Asn Gly Ala Lys Arg Ile Asn Phe Glu Lys Phe Ile 
        675                 680                 685             


Leu Gln Met Phe Val Lys Gly Phe Asp Ser Phe Leu Lys Asp Gly Ala 
    690                 695                 700                 


Phe Glu Phe Val His Ser Pro Glu Asn Cys Leu Thr Gly Ser Thr Glu 
705                 710                 715                 720 


Lys Glu Arg Ala Lys Glu Arg Asn Ser Leu Cys Glu Glu Ile Gly Asn 
                725                 730                 735     


Tyr Val Arg Leu Val Ser Thr Val Ile Asp Pro Gly Lys Gly Ser His 
            740                 745                 750         


Val Ala Phe Tyr Val Phe Cys Lys Met Leu Asn Ser Val Tyr Leu Ser 
        755                 760                 765             


Asn Ile Arg Asn Glu Met Ile Lys Tyr His Lys Val Val Arg Thr Asp 
    770                 775                 780                 


Glu Leu Ala His Leu Ile Glu Ile Ile Glu Leu Cys Leu Leu Ser Ala 
785                 790                 795                 800 


Asp Ala Val Ser Gln Lys Thr Val Asn Ala Asp Lys Leu Ser His Phe 
                805                 810                 815     


Phe Ala Glu Gly Val Asn Val Asp Asp Asp Glu Asn Val Ile His Ala 
            820                 825                 830         


Ser Met Glu Thr Phe Arg Lys Tyr Gly Thr Arg Asp Leu Phe His Lys 
        835                 840                 845             


Leu Met Leu Gln Asp Asp Arg Phe Leu Val Ser Ser Asp Asp Tyr Arg 
    850                 855                 860                 


Glu Trp Glu Glu Met Lys Glu Lys Ile Glu Gly Lys Val Lys Gln Arg 
865                 870                 875                 880 


Glu Leu Leu His Ala Glu Trp Cys Glu Ala Lys Glu Lys Asp Lys Lys 
                885                 890                 895     


Ser Arg Lys Val Lys Ser Asn Ser Arg Thr Cys Phe Glu Lys Lys Phe 
            900                 905                 910         


Met Gly Ala Lys Ala Glu Glu Tyr Tyr Ser Leu Cys Lys Val Ile Asp 
        915                 920                 925             


Lys Tyr Asn Trp Leu Asp Asn Lys Leu His Leu Val His Leu Asn Lys 
    930                 935                 940                 


Leu His Asn Leu Val Ile Glu Ile Leu Gly Arg Met Val Gly Phe Thr 
945                 950                 955                 960 


Ala Leu Phe Glu Arg Asp Phe Gln Tyr Ile Cys Lys Ser Asp Ser Glu 
                965                 970                 975     


Tyr Glu Gln Leu Tyr Asn Leu Asp Phe Asn Met Gly Leu Pro Lys Phe 
            980                 985                 990         


Lys Asn Ser Ile Lys Gly Ser Gly  Lys Ala Lys Asn Ser  Thr Gln Asn 
        995                 1000                 1005             


Ile Asp  His Asn Ala Thr Gly  Ile Gly Asn Ser Ser  Asn Leu Leu 
    1010                 1015                 1020             


Lys Glu  Asn Ser Asn Gly Thr  His Tyr Cys Lys Asn  Leu Ser Gly 
    1025                 1030                 1035             


Asp Gly  Val Glu Asp Lys Leu  Lys Arg Leu Phe Leu  Tyr Asp Asp 
    1040                 1045                 1050             


Tyr Arg  Asn Val Arg Asn Phe  Val Ala His Phe Asn  Tyr Leu Thr 
    1055                 1060                 1065             


Arg Val  Glu Asp Asp Leu Gly  Gly Asn Asp Ala Val  Lys Leu Ser 
    1070                 1075                 1080             


Gly Thr  Arg Tyr Ser Leu Ile  Glu Leu Ile Asn Glu  Leu Arg Asn 
    1085                 1090                 1095             


Leu Leu  Lys Tyr Asp Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ser 
    1100                 1105                 1110             


Phe Ile  Asp Met Phe Glu Arg  His Gly Met His Val  Lys Met Lys 
    1115                 1120                 1125             


Leu Asn  His Asn His Lys Leu  Phe Val Asp Ser Ile  Ser Pro Arg 
    1130                 1135                 1140             


Lys Ile  Lys His Leu Gly Gly  Gly Tyr Lys Lys Arg  Gly Lys Asp 
    1145                 1150                 1155             


Asp Lys  Met Tyr Val Gln Thr  Thr Asn His Val Asp  Pro Leu Tyr 
    1160                 1165                 1170             


Cys Asp  Met Cys Arg Ala Leu  Leu Glu Met Lys 
    1175                 1180                 


<210>  1248
<211>  966
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1248

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser 
                965     


<210>  1249
<211>  1184
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1249

Met Arg Val Ser Lys Val Lys Val Leu Gly Asn Glu Glu Thr Lys Gly 
1               5                   10                  15      


Arg Ile Val Leu Met His Arg Ser Pro Val Lys Gly Gln Leu Ile Tyr 
            20                  25                  30          


Ser Glu Asp Ala Gly Lys Arg Asp Arg Thr Glu Asp Ile Ile Pro Glu 
        35                  40                  45              


Gln Lys Leu Glu Ser Phe His Leu Ser Ile Leu Asn Lys Thr Phe Leu 
    50                  55                  60                  


Arg Lys Glu Phe Phe Lys Lys Glu Leu Lys His Glu Ala Lys Lys Asn 
65                  70                  75                  80  


Gly Leu Lys Gly Asp Ala Glu Asp Lys Tyr Ile Ser Glu Lys Leu Lys 
                85                  90                  95      


Glu Tyr His Ser Leu Leu Gln Phe Ile Asp Asp Val Leu Ser Val Lys 
            100                 105                 110         


Tyr Asn Glu Asn Arg Lys Ala Ile Lys Phe Pro Glu Tyr Leu Thr Arg 
        115                 120                 125             


Glu Met Ile Glu Ile Phe Leu Asn His Lys Phe Arg Lys Glu Val Thr 
    130                 135                 140                 


Tyr Thr Asn Lys Asn Gly Ala Ser Val Ser Phe Leu Leu Ser Thr Leu 
145                 150                 155                 160 


Ile Leu Asn Ala Ile Glu Lys His Ser Val Ile Glu Met Gln Pro Phe 
                165                 170                 175     


Val Asp Trp Arg Asn Trp Phe Val Glu Thr Lys Ser Lys Phe Leu Lys 
            180                 185                 190         


Lys Ser Ile Ile Asn Asn Cys Ile Pro Thr Asn Gly Gly Pro Ile Ser 
        195                 200                 205             


Arg Arg Arg Glu Thr Leu Met Lys Trp Arg Asp Asp Tyr Phe Thr Asn 
    210                 215                 220                 


Ala Glu Ile Asp Leu Ala Arg Leu His Lys Lys Phe Gly Thr Asp Thr 
225                 230                 235                 240 


Leu Met Ala Ser Leu Arg Glu Val Pro Gln Thr Glu Lys Ser Gly Asn 
                245                 250                 255     


Glu Tyr His Arg Leu Leu Lys Ser Cys Leu Gln Ser His Gln Lys Lys 
            260                 265                 270         


Leu Phe Gly Lys Arg Ala Glu Gly Tyr Asp Ile Asn Arg Ala Asp Asn 
        275                 280                 285             


Gln Leu Tyr Val Tyr Asn Thr Glu Val Val Lys Tyr Met Glu His Tyr 
    290                 295                 300                 


Phe Pro Val Lys Ser Ser Lys Arg Arg Asn Ser Thr Ala Glu Ile Lys 
305                 310                 315                 320 


Tyr Tyr Leu Gln Thr Asp Thr Ile Lys Cys Cys Leu His His Gln Ile 
                325                 330                 335     


Ile Asn Ala Val Arg Gly Leu Ala Leu Arg Glu Gly Lys Phe Asn Leu 
            340                 345                 350         


His Gly Phe Asp Asp Lys Leu Ile Pro Asn Glu Arg Asn Val Ser Ser 
        355                 360                 365             


Ser Ile Leu Asn Glu Leu Lys Thr Ser Glu Gly Phe Val Leu Asn Met 
    370                 375                 380                 


Leu Gly Gly Cys Ala Phe Ala Ala Asn Cys Leu Arg Asn Ile Val Asp 
385                 390                 395                 400 


Ala Thr Gln Arg Ser Asp Leu Leu Gly Phe Arg Cys Phe Glu Val Ser 
                405                 410                 415     


Leu Lys Lys Gly Lys Ser Asn Ser Asp Leu Phe Ala Leu Phe Phe Gly 
            420                 425                 430         


Phe Gly Arg Glu Asp Met Asp Asp Asp Ser Glu Trp Glu Lys His Leu 
        435                 440                 445             


Tyr Ala Ala Arg Tyr Ser Val Ser Glu Ile Arg Asn Arg Val Ala His 
    450                 455                 460                 


Tyr His Lys Ser Ala Ile Glu Asn Ile Tyr Asn Ile Thr Asp Phe Glu 
465                 470                 475                 480 


Tyr Arg Glu Asn Ser Met Cys Ser Tyr Thr Asp Thr Lys Phe Thr Thr 
                485                 490                 495     


Ala Leu Gln Asn Glu Ile Tyr Asn Thr Pro Lys Ala Phe Ser Leu Gln 
            500                 505                 510         


Leu Met Thr Gly Lys Val Leu Glu Tyr Tyr Pro Lys Glu Lys Leu Val 
        515                 520                 525             


Ser Phe Phe Gln Lys Tyr Lys Phe Ser Leu Tyr Arg Ser Val Val Pro 
    530                 535                 540                 


Phe Ala Pro Gly Phe Lys Asn Ile Met Arg Thr Gly Val Asn Tyr Gln 
545                 550                 555                 560 


Asn Ala Thr Gln Asn Arg Leu Phe Tyr Asp Met Gly Leu Thr Ala Phe 
                565                 570                 575     


Gln Asp Lys Asp Arg Tyr Ile Asp Asp Val Glu Ala Trp Asn Ala Arg 
            580                 585                 590         


Tyr Phe Phe Met Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Arg Phe 
        595                 600                 605             


Thr Asn Asp Lys Asn Asp Leu Phe Arg Lys Thr Val Glu Gln Val Leu 
    610                 615                 620                 


Glu Val Asn Arg Ser His Met Glu Lys Val Gly Lys Asp Asp Arg Gln 
625                 630                 635                 640 


Ala Phe Gly Glu Val Arg Gln Met Arg Glu Asn Glu Thr Ala Asn Asp 
                645                 650                 655     


Tyr Met Ala Tyr Leu Gln Ser Ser Leu Arg Met Glu Lys Asn Lys Lys 
            660                 665                 670         


Glu Leu Glu Gly Asn Gly Ala Lys Arg Ile Asn Phe Glu Lys Phe Ile 
        675                 680                 685             


Leu Gln Met Phe Val Lys Gly Phe Asp Ser Phe Leu Lys Asp Gly Ala 
    690                 695                 700                 


Phe Glu Phe Val His Ser Pro Glu Asn Cys Leu Thr Gly Ser Thr Glu 
705                 710                 715                 720 


Lys Glu Arg Ala Lys Glu Arg Asn Ser Leu Cys Glu Glu Ile Gly Asn 
                725                 730                 735     


Tyr Val Arg Leu Val Ser Thr Val Ile Asp Pro Gly Lys Gly Ser His 
            740                 745                 750         


Val Ala Phe Tyr Val Phe Cys Lys Met Leu Asn Ser Val Tyr Leu Ser 
        755                 760                 765             


Asn Ile Arg Asn Glu Met Ile Lys Tyr His Lys Val Val Arg Thr Asp 
    770                 775                 780                 


Glu Leu Ala His Leu Ile Glu Ile Ile Glu Leu Cys Leu Leu Ser Ala 
785                 790                 795                 800 


Asp Ala Val Ser Gln Lys Thr Val Asn Ala Asp Lys Leu Ser His Phe 
                805                 810                 815     


Phe Ala Glu Gly Val Asn Val Asp Asp Asp Glu Asn Val Ile His Ala 
            820                 825                 830         


Ser Met Glu Thr Phe Arg Lys Tyr Gly Thr Arg Asp Leu Phe His Lys 
        835                 840                 845             


Leu Met Leu Gln Asp Asp Arg Phe Leu Val Ser Ser Asp Asp Tyr Arg 
    850                 855                 860                 


Glu Trp Glu Glu Met Lys Glu Lys Ile Glu Gly Lys Val Lys Gln Arg 
865                 870                 875                 880 


Glu Leu Leu His Ala Glu Trp Cys Glu Ala Lys Glu Lys Asp Lys Lys 
                885                 890                 895     


Ser Arg Lys Val Lys Ser Asn Ser Arg Thr Cys Phe Glu Lys Lys Phe 
            900                 905                 910         


Met Gly Ala Lys Ala Glu Glu Tyr Tyr Ser Leu Cys Asn Val Ile Asp 
        915                 920                 925             


Lys Tyr Asn Trp Leu Asp Asn Lys Leu His Leu Val His Leu Asn Lys 
    930                 935                 940                 


Leu His Asn Leu Val Ile Glu Ile Leu Gly Arg Met Val Gly Phe Thr 
945                 950                 955                 960 


Ala Leu Phe Glu Arg Asp Phe Gln Tyr Ile Cys Lys Ser Asp Ser Glu 
                965                 970                 975     


Tyr Glu Gln Leu Tyr Asn Leu Asp Phe Asn Met Gly Leu Pro Lys Phe 
            980                 985                 990         


Lys Asn Ser Ile Lys Gly Ser Gly  Lys Ala Lys Asn Ser  Thr Gln Asn 
        995                 1000                 1005             


Ile Asp  His Asn Ala Thr Gly  Ile Gly Asn Ser Ser  Asn Leu Leu 
    1010                 1015                 1020             


Lys Glu  Asn Ser Asn Gly Thr  His Tyr Cys Lys Asn  Leu Ser Gly 
    1025                 1030                 1035             


Asp Gly  Val Glu Asp Lys Leu  Lys Arg Leu Phe Leu  Tyr Asp Asp 
    1040                 1045                 1050             


Tyr Arg  Asn Val Arg Asn Phe  Val Ala His Phe Asn  Tyr Leu Thr 
    1055                 1060                 1065             


Arg Val  Glu Asp Asp Leu Gly  Gly Asn Asp Ala Val  Lys Leu Ser 
    1070                 1075                 1080             


Gly Thr  Arg Tyr Ser Leu Ile  Glu Leu Ile Asn Glu  Leu Arg Asn 
    1085                 1090                 1095             


Leu Leu  Lys Tyr Asp Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ser 
    1100                 1105                 1110             


Phe Ile  Asp Met Phe Glu Arg  His Gly Met His Val  Lys Met Lys 
    1115                 1120                 1125             


Leu Asn  His Asn His Lys Leu  Phe Val Asp Ser Ile  Ser Pro Arg 
    1130                 1135                 1140             


Lys Ile  Lys His Leu Gly Gly  Gly Tyr Lys Lys Arg  Gly Lys Asp 
    1145                 1150                 1155             


Asp Lys  Met Tyr Val Gln Thr  Thr Asn His Val Asp  Pro Leu Tyr 
    1160                 1165                 1170             


Cys Asp  Met Cys Arg Ala Leu  Leu Glu Met Lys 
    1175                 1180                 


<210>  1250
<211>  1184
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1250

Met Arg Val Ser Lys Val Lys Val Leu Gly Asn Glu Glu Thr Lys Gly 
1               5                   10                  15      


Arg Ile Val Leu Met His Arg Ser Pro Val Lys Gly Gln Leu Ile Tyr 
            20                  25                  30          


Ser Glu Asp Ala Gly Lys Arg Asp Arg Thr Glu Asp Ile Ile Pro Glu 
        35                  40                  45              


Gln Lys Leu Glu Ser Phe His Leu Ser Ile Leu Asn Lys Thr Phe Leu 
    50                  55                  60                  


Arg Lys Glu Phe Phe Lys Lys Glu Leu Lys His Glu Ala Lys Lys Asn 
65                  70                  75                  80  


Gly Leu Lys Gly Asp Ala Glu Asp Lys Tyr Ile Ser Glu Lys Leu Lys 
                85                  90                  95      


Glu Tyr His Ser Leu Leu Gln Phe Ile Asp Asp Val Leu Ser Val Lys 
            100                 105                 110         


Tyr Asn Glu Asn Arg Lys Ala Ile Lys Phe Pro Glu Tyr Leu Thr Arg 
        115                 120                 125             


Glu Met Ile Glu Ile Phe Leu Asn His Lys Phe Arg Lys Glu Val Thr 
    130                 135                 140                 


Tyr Thr Asn Lys Asn Gly Ala Ser Val Ser Phe Leu Leu Ser Thr Leu 
145                 150                 155                 160 


Ile Leu Asn Ala Ile Glu Lys His Ser Val Ile Glu Met Gln Pro Phe 
                165                 170                 175     


Val Asp Trp Arg Asn Trp Phe Val Glu Thr Lys Ser Lys Phe Leu Lys 
            180                 185                 190         


Lys Ser Ile Ile Asn Asn Cys Ile Pro Thr Asn Gly Gly Pro Ile Ser 
        195                 200                 205             


Arg Arg Arg Glu Thr Leu Met Lys Trp Arg Asp Asp Tyr Phe Thr Asn 
    210                 215                 220                 


Ala Glu Ile Asp Leu Ala Arg Leu His Lys Lys Phe Gly Thr Asp Thr 
225                 230                 235                 240 


Leu Met Ala Ser Leu Arg Glu Val Pro Gln Thr Glu Lys Ser Gly Asn 
                245                 250                 255     


Glu Tyr His Arg Leu Leu Lys Ser Cys Leu Gln Ser His Gln Lys Lys 
            260                 265                 270         


Leu Phe Gly Lys Arg Ala Glu Gly Tyr Asp Ile Asn Arg Ala Asp Asn 
        275                 280                 285             


Gln Leu Tyr Val Tyr Asn Thr Glu Val Val Lys Tyr Met Glu His Tyr 
    290                 295                 300                 


Phe Pro Val Lys Ser Ser Lys Arg Arg Asn Ser Thr Ala Glu Ile Lys 
305                 310                 315                 320 


Tyr Tyr Leu Gln Thr Asp Thr Ile Lys Cys Cys Leu His His Gln Ile 
                325                 330                 335     


Ile Asn Ala Val Arg Gly Leu Ala Leu Arg Glu Gly Lys Phe Asn Leu 
            340                 345                 350         


His Gly Phe Asp Asp Lys Leu Ile Pro Asn Glu Arg Asn Val Ser Ser 
        355                 360                 365             


Ser Ile Leu Asn Glu Leu Lys Thr Ser Glu Gly Phe Val Leu Asn Met 
    370                 375                 380                 


Leu Gly Gly Cys Ala Phe Ala Ala Asn Cys Leu Arg Asn Ile Val Asp 
385                 390                 395                 400 


Ala Thr Gln Arg Ser Asp Leu Leu Gly Phe Arg Cys Phe Glu Val Ser 
                405                 410                 415     


Leu Lys Lys Gly Lys Ser Asn Ser Asp Leu Phe Ala Leu Phe Phe Gly 
            420                 425                 430         


Phe Gly Arg Glu Asp Met Asp Asp Asp Ser Glu Trp Glu Lys His Leu 
        435                 440                 445             


Tyr Ala Ala Arg Tyr Ser Val Ser Glu Ile Arg Asn Arg Val Ala His 
    450                 455                 460                 


Tyr His Lys Ser Ala Ile Glu Asn Ile Tyr Asn Ile Thr Asp Phe Glu 
465                 470                 475                 480 


Tyr Arg Glu Asn Ser Met Cys Ser Tyr Thr Asp Thr Lys Phe Thr Thr 
                485                 490                 495     


Ala Leu Gln Asn Glu Ile Tyr Asn Thr Pro Lys Ala Phe Ser Leu Gln 
            500                 505                 510         


Leu Met Thr Gly Lys Val Leu Glu Tyr Tyr Pro Lys Glu Lys Leu Val 
        515                 520                 525             


Ser Phe Phe Gln Lys Tyr Lys Phe Ser Leu Tyr Arg Ser Val Val Pro 
    530                 535                 540                 


Phe Ala Pro Gly Phe Lys Asn Ile Met Arg Thr Gly Val Asn Tyr Gln 
545                 550                 555                 560 


Asn Ala Thr Gln Asn Arg Leu Phe Tyr Asp Met Gly Leu Thr Ala Phe 
                565                 570                 575     


Gln Asp Lys Asp Arg Tyr Ile Asp Asp Val Glu Ala Trp Asn Ala Arg 
            580                 585                 590         


Tyr Phe Phe Met Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Arg Phe 
        595                 600                 605             


Thr Asn Asp Lys Asn Asp Leu Phe Arg Lys Thr Val Glu Gln Val Leu 
    610                 615                 620                 


Glu Val Asn Arg Ser His Met Glu Lys Val Gly Lys Asp Asp Arg Gln 
625                 630                 635                 640 


Ala Phe Gly Glu Val Arg Gln Met Arg Glu Asn Glu Thr Ala Asn Asp 
                645                 650                 655     


Tyr Met Ala Tyr Leu Gln Ser Ser Leu Arg Met Glu Lys Asn Lys Lys 
            660                 665                 670         


Glu Leu Glu Gly Asn Gly Ala Lys Arg Ile Asn Phe Glu Lys Phe Ile 
        675                 680                 685             


Leu Gln Met Phe Val Lys Gly Phe Asp Ser Phe Leu Lys Asp Gly Ala 
    690                 695                 700                 


Phe Glu Phe Val His Ser Pro Glu Asn Cys Leu Thr Gly Ser Thr Glu 
705                 710                 715                 720 


Lys Glu Arg Ala Lys Glu Arg Asn Ser Leu Cys Glu Glu Ile Gly Asn 
                725                 730                 735     


Tyr Val Arg Leu Val Ser Thr Val Ile Asp Pro Gly Lys Gly Ser His 
            740                 745                 750         


Val Ala Phe Tyr Val Phe Cys Lys Met Leu Asn Ser Val Tyr Leu Ser 
        755                 760                 765             


Asn Ile Arg Asn Glu Met Ile Lys Tyr His Lys Val Val Arg Thr Asp 
    770                 775                 780                 


Glu Leu Ala His Leu Ile Glu Ile Ile Glu Leu Cys Leu Leu Ser Ala 
785                 790                 795                 800 


Asp Ala Val Ser Gln Lys Thr Val Asn Ala Asp Lys Leu Ser His Phe 
                805                 810                 815     


Phe Ala Glu Gly Val Asn Val Asp Asp Asp Glu Asn Val Ile His Ala 
            820                 825                 830         


Ser Met Glu Thr Phe Arg Lys Tyr Gly Thr Arg Asp Leu Phe His Lys 
        835                 840                 845             


Leu Met Leu Gln Asp Asp Arg Phe Leu Val Ser Ser Asp Asp Tyr Arg 
    850                 855                 860                 


Glu Trp Glu Glu Met Lys Glu Lys Ile Glu Gly Lys Val Lys Gln Arg 
865                 870                 875                 880 


Glu Leu Leu His Ala Glu Trp Cys Glu Ala Lys Glu Lys Asp Lys Lys 
                885                 890                 895     


Ser Arg Lys Val Lys Ser Asn Ser Arg Thr Cys Phe Glu Lys Lys Phe 
            900                 905                 910         


Met Gly Ala Lys Ala Glu Glu Tyr Tyr Ser Leu Cys Lys Val Ile Asp 
        915                 920                 925             


Lys Tyr Asn Trp Leu Asp Asn Lys Leu His Leu Val His Leu Asn Lys 
    930                 935                 940                 


Leu His Asn Leu Val Ile Glu Ile Leu Gly Arg Met Val Gly Phe Thr 
945                 950                 955                 960 


Ala Leu Phe Glu Arg Asp Phe Gln Tyr Ile Cys Lys Ser Asp Ser Glu 
                965                 970                 975     


Tyr Glu Gln Leu Tyr Asn Leu Asp Phe Asn Met Gly Leu Pro Lys Phe 
            980                 985                 990         


Lys Asn Ser Ile Lys Gly Ser Gly  Lys Ala Lys Asn Ser  Thr Gln Asn 
        995                 1000                 1005             


Ile Asp  His Asn Ala Thr Gly  Ile Gly Asn Ser Ser  Asn Leu Leu 
    1010                 1015                 1020             


Lys Glu  Asn Ser Asn Gly Thr  His Tyr Cys Lys Asn  Leu Ser Gly 
    1025                 1030                 1035             


Asp Gly  Val Glu Asp Lys Leu  Lys Arg Leu Phe Leu  Tyr Asp Asp 
    1040                 1045                 1050             


Tyr Arg  Asn Val Arg Asn Phe  Val Ala His Phe Asn  Tyr Leu Thr 
    1055                 1060                 1065             


Arg Val  Glu Asp Asp Leu Gly  Gly Asn Asp Ala Val  Lys Leu Ser 
    1070                 1075                 1080             


Gly Thr  Arg Tyr Ser Leu Ile  Glu Leu Ile Asn Glu  Leu Arg Asn 
    1085                 1090                 1095             


Leu Leu  Lys Tyr Asp Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ser 
    1100                 1105                 1110             


Phe Ile  Asp Met Phe Glu Arg  His Gly Met His Val  Lys Met Lys 
    1115                 1120                 1125             


Leu Asn  His Asn His Lys Leu  Phe Val Asp Ser Ile  Ser Pro Arg 
    1130                 1135                 1140             


Lys Ile  Lys His Leu Gly Gly  Gly Tyr Lys Lys Arg  Gly Lys Asp 
    1145                 1150                 1155             


Asp Lys  Met Tyr Val Gln Thr  Thr Asn His Val Asp  Pro Leu Tyr 
    1160                 1165                 1170             


Cys Asp  Met Cys Arg Ala Leu  Leu Glu Met Lys 
    1175                 1180                 


<210>  1251
<211>  1287
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1251

Met Arg Ile Gly Lys Val Gln Gly Arg Thr Phe Thr Gly Phe Asp Asn 
1               5                   10                  15      


Ala Arg Gly Lys Thr Leu Arg Arg Arg Leu Leu Thr Arg Pro Asp Asn 
            20                  25                  30          


Glu Ala Arg Ser Leu Ser Glu His Leu Ala His Asp Pro Lys Ala Leu 
        35                  40                  45              


Ile Gly Gln Ala Ile Ser Arg Ile Asp Thr Ile Tyr Gln Lys Pro Lys 
    50                  55                  60                  


Thr Gly Lys Pro Thr Pro Glu Gln Phe Gly His Arg Asp Thr Leu Gly 
65                  70                  75                  80  


Trp Ala Tyr Trp Lys Leu Leu Val Ala Ser Tyr Pro Glu Val Glu Gly 
                85                  90                  95      


His Arg Asp Leu Phe Val Arg Arg Leu His Pro Tyr Gly Asp Thr Pro 
            100                 105                 110         


Pro Lys Ser His Gly Gln Lys Glu Gly Glu His Gln Lys Gly Gly Lys 
        115                 120                 125             


Pro Gln Leu Glu Gly Arg Trp His Gly Val Met Ala Gln His Gly Lys 
    130                 135                 140                 


Asn Pro Asp Gln Ile Ala Ala Arg Leu Phe Asp His Leu His Asn Ser 
145                 150                 155                 160 


Glu Leu Arg Phe Gly Gly Thr Ala Ser Gly Glu Pro Arg Thr Arg Pro 
                165                 170                 175     


Gly Lys Glu Ala Thr Pro Thr Gly Leu Ile Gly Ala Arg Ala Lys Thr 
            180                 185                 190         


Ile Glu His Ser Val Leu Pro Arg Asp Ala Lys Arg Phe Val Ala Glu 
        195                 200                 205             


Trp Arg Gly Glu Asp Gln Glu Arg Tyr Ala Gly Ala Arg Asp Ile Ala 
    210                 215                 220                 


Ala Ala Ile Ser Ala Gly Leu Asn Asp Lys Asp Gln Lys Ser Gly Ser 
225                 230                 235                 240 


Gly Arg Lys Ser Ala Val Ile Gly Lys Leu Leu Ser Asp His Leu Glu 
                245                 250                 255     


Thr Leu Thr Gly Asn Arg Lys Cys Arg Phe Asp Pro Lys Ser Thr Ala 
            260                 265                 270         


Glu Thr Leu Glu Leu Arg Asp Gly Glu Ser Val Asp Asp Arg Arg Arg 
        275                 280                 285             


Ile Leu Glu Leu His Ala Glu Val Lys Ala Thr Tyr Lys Arg Met Ala 
    290                 295                 300                 


Ala Trp Lys Pro Ala Lys Leu Pro Arg Asn Ser Asp Glu Leu Phe Arg 
305                 310                 315                 320 


Leu Val Arg Gln Gln Ala Asp Asn Arg Ile Leu Asn His Leu Val Arg 
                325                 330                 335     


Val Gly Arg Ile Ser Val Tyr Ser Glu Gln Ser Asp Ala Leu Ser Glu 
            340                 345                 350         


Ser Gln Phe Trp Thr Ser Gly Gly Gln Thr Gln Ile Lys Glu Ser Glu 
        355                 360                 365             


Val Phe Ala Arg Leu Trp Ile Gly Ala Ile Ser Arg Ala Ser Tyr Ser 
    370                 375                 380                 


Met Lys Ala Trp Leu Glu Pro Glu Gly Thr Val Phe Asn Pro Ser Ile 
385                 390                 395                 400 


Asn Asp Phe Asp Val Thr Ser Ser His Asn Thr Asn Arg Ile Leu Glu 
                405                 410                 415     


Asp Ser Gly Arg Leu Ser Asn Ala Met Ala Arg Arg Ala Ile Tyr Phe 
            420                 425                 430         


Gly Glu Thr Pro Glu Phe Asp Ala Leu Gly Glu Glu Asp Gln Arg Val 
        435                 440                 445             


Leu Val Lys Lys Cys Leu Asp Ala Leu Ser Ala Cys Arg Asn Arg Thr 
    450                 455                 460                 


Phe His His Gly Gln Arg Ala Lys Phe Leu Lys Glu Val Arg Lys Gly 
465                 470                 475                 480 


Leu Lys Glu Lys Glu Ala Asp Ser Ala Gly Pro Ala Ala Trp Glu Gly 
                485                 490                 495     


Ile Arg Glu Val Ile Gln Ala Asp Ala Arg Asn Leu Gly Ala Arg Leu 
            500                 505                 510         


Leu Gln Asp Leu Thr Gly Ala Lys Val His Ser Phe Ala Thr Asp Pro 
        515                 520                 525             


Glu Phe Arg His Leu Tyr Glu Ser Val Ala Ala Thr Leu Thr Ala Gly 
    530                 535                 540                 


Gly Glu Leu Glu Ala Ala Leu Pro Arg Leu Lys Asn Val Leu Lys Arg 
545                 550                 555                 560 


Ala Glu Gly Val Arg Cys Tyr Leu Asp Thr Pro Ser Gln Arg Arg Glu 
                565                 570                 575     


Gly Asp Glu Ser Leu Ile Ala Arg Leu Pro Val Ala Pro Val Pro Arg 
            580                 585                 590         


Glu Leu Asp Asp Ala Ala Thr Lys Ala Arg His Ser Ala Leu Leu Arg 
        595                 600                 605             


Leu Tyr Asp Gly Pro Phe Arg Pro Trp Ala Thr Glu Leu Arg Gly Glu 
    610                 615                 620                 


Arg Leu Ser Asp Tyr Ala Ala Arg Ala Lys Arg Leu Ala Thr Arg Leu 
625                 630                 635                 640 


Ala Lys Ser Thr Asn Thr Ala Ser Pro Tyr Pro Asp Ser Val Glu Gly 
                645                 650                 655     


Arg Ser Val Arg Leu Arg Asp Pro Ile Thr Ala Asp Thr Ala Pro Glu 
            660                 665                 670         


Thr Leu Lys Thr Tyr Leu Ser Ala Leu Thr Ala Glu Thr Ala Thr Glu 
        675                 680                 685             


Phe Arg Val Gln Lys Gly Tyr Glu Ser Asp Gly Glu Lys Ala Lys Glu 
    690                 695                 700                 


Gln Ala Glu Phe Ile Glu Asp Phe Arg Arg Asp Met Ile Ala Leu Ala 
705                 710                 715                 720 


Phe Gln Asp Phe Ile Arg Asp His Gly Phe Ala Trp Leu Leu Asp Ile 
                725                 730                 735     


Ala Ser Lys Ala Glu Pro Ser Asn Asp Ala Pro Asn Leu Pro Asp Pro 
            740                 745                 750         


Val Asp Thr Gly Lys Asp Thr Val Phe Glu Asp Trp Gln Ala Leu Leu 
        755                 760                 765             


Tyr Leu Phe Leu His Phe Val Pro Ala Asp Asp Val Ser Gln Leu Leu 
    770                 775                 780                 


His Gln Leu Arg Lys Trp Asp Ala Leu Gln Asp Lys Tyr Glu Leu Ala 
785                 790                 795                 800 


Glu Pro Gly Glu Thr Leu Gly Gln Thr Lys Ala Asp Thr Arg Lys Ile 
                805                 810                 815     


Val Gly Gln Phe Arg Asp Cys Leu Thr Leu Phe Leu Lys Thr Gly Asp 
            820                 825                 830         


Ala Arg Phe Asp Gly Glu Gly Val Glu Leu Pro Leu Ser Asp Phe Gln 
        835                 840                 845             


Glu Leu Phe Glu Ser Pro Ala Thr Phe Lys Glu Leu Phe Leu Ala Glu 
    850                 855                 860                 


Pro Ala Glu Asn Asp Ala Ser Glu Thr Asp Asp Gln Asp Ala Pro Gly 
865                 870                 875                 880 


Glu Lys His Arg Val Thr Arg Thr Arg Arg Gly Leu Arg Gln Ile Leu 
                885                 890                 895     


Arg Tyr Asn His Met Pro Val Leu Arg Asp Leu Phe Leu Ala His Lys 
            900                 905                 910         


Val Thr Asp Ala Glu Val Asp Gly Leu Gln Ala Leu Glu Val Asp Asp 
        915                 920                 925             


Pro Gln Thr Gly Glu Ser Gln Ile Gly Ala Ala Gln Arg Ile Arg Thr 
    930                 935                 940                 


Glu Ile His His His Thr Ser Asn Asp Lys Gln Ile Ser Glu Ala Lys 
945                 950                 955                 960 


Val Glu Glu Tyr Arg Arg Ala Leu Ser Thr Ile Glu Arg His Arg Phe 
                965                 970                 975     


Leu Val Gly Arg Val Tyr Leu Gly Asp His Ile Arg Val His Lys Leu 
            980                 985                 990         


Met Met Asp Val Met Gly Arg Leu  Val Asp Phe Ala Gly  Ala Trp Glu 
        995                 1000                 1005             


Arg Glu  Ala Ala Asp Gly Asp  Arg Lys Gly Phe Ile  Ser Arg Ala 
    1010                 1015                 1020             


Ile Ala  Leu Pro Glu Val Ala  Glu Gly Tyr Ala Ala  Asp Arg Leu 
    1025                 1030                 1035             


Lys Thr  Val Ala Arg Arg Val  Leu Asp Asp Gly Glu  Ala Arg Arg 
    1040                 1045                 1050             


Ile Arg  Asn Asp Leu Gly His  Phe Asn Asp Leu Ala  Pro Thr Ser 
    1055                 1060                 1065             


Gly Pro  Ala Asn Leu Thr Phe  Val Val Asn Arg Ala  Arg Arg Met 
    1070                 1075                 1080             


Met Arg  His Asp Arg Lys Arg  Lys Asn Ala Val Thr  Lys Ser Val 
    1085                 1090                 1095             


Ile Glu  Ile Leu Asn Arg Gln  Gly Leu Gly Ile Glu  Trp Thr Met 
    1100                 1105                 1110             


Arg Asn  His Glu Leu Cys Glu  Ala Lys Leu Trp Gln  Asn Pro Val 
    1115                 1120                 1125             


Lys His  Leu Gly Phe Ala Thr  Leu Glu Gly Arg Gly  Lys Lys Trp 
    1130                 1135                 1140             


Arg Arg  Pro Phe Glu Ala Arg  Tyr Gly Asp Ala Tyr  Met Ala Met 
    1145                 1150                 1155             


Val Ala  Gln Leu Phe Asp Gly  Thr Val Thr Ser Pro  Pro Ala Lys 
    1160                 1165                 1170             


Gly Pro  Pro Gln Ser Gly Lys  Ser Gly Gly Lys Pro  Gly Lys Gly 
    1175                 1180                 1185             


Ala Glu  Gly Gly Ala Lys Glu  Lys Ser Arg Ser Pro  Thr Arg Met 
    1190                 1195                 1200             


Glu Glu  Gly Gly Val Tyr Glu  Gly Arg Val Ala Lys  Ala Lys Ser 
    1205                 1210                 1215             


Asp Lys  Gly Phe Gly Phe Leu  Leu Val Glu Gly Ala  Gln Glu Glu 
    1220                 1225                 1230             


Ile Phe  Leu His Ile Tyr Gly  Ile Ser Gly Asn Arg  Pro Ala Arg 
    1235                 1240                 1245             


Ile Glu  Asn Gly Gln Arg Tyr  Arg Phe Thr Leu Gly  Ile Asp Arg 
    1250                 1255                 1260             


Asp Arg  Glu Arg Arg Lys Glu  Arg Ala Trp Val Ala  Arg Glu Ala 
    1265                 1270                 1275             


Val Arg  Ile Asp Glu Asn Arg  Ser Lys 
    1280                 1285         


<210>  1252
<211>  1153
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1252

Met Pro Ile Ile Lys Lys Phe Gly Arg Ser Thr Ser Ser Leu Thr Glu 
1               5                   10                  15      


Arg Thr Leu Ile Leu Gly Ala Lys Arg Thr Glu Glu His Gly Ser Val 
            20                  25                  30          


Arg Lys Ile Pro Glu Phe Leu Thr His Asp Ala Glu Ala Leu Leu Gly 
        35                  40                  45              


Gln Trp Ala Ser Ala Met Asp Lys Val Ala Ser Lys Pro Lys Gly Arg 
    50                  55                  60                  


Asp Lys Pro Ser Ala Phe Gln Arg Ser Phe Arg Glu Asp Leu Gly Ser 
65                  70                  75                  80  


Ala Ile Trp Ala Asp Leu Thr Ser Ala Asp Gly Pro Phe Ala Arg Leu 
                85                  90                  95      


Asp Glu Lys Ala Arg Asp Ile Leu His Lys Lys Trp Asp Arg Arg Ile 
            100                 105                 110         


His Pro Tyr Pro Asp Gly Thr Ala Ala Glu His Lys Pro Ala Ser Pro 
        115                 120                 125             


Lys Gly Arg Leu Tyr Ser Met Phe Ala Gly Glu Val Gly Tyr Gly Ala 
    130                 135                 140                 


Ala Asp Lys Pro Ala Ile Ala Arg Lys Ile Arg Leu His Leu Leu Gly 
145                 150                 155                 160 


Glu Glu Leu Arg Lys Ser Gly Gly Thr Arg Pro Gln Gly His Ala Val 
                165                 170                 175     


Arg Arg Ala Asn Ser Ile Glu Lys Asn Thr Leu Pro Lys Ile Lys Ala 
            180                 185                 190         


Thr Pro Val Pro Asp Trp Asp Asp Ala Asp Ile Val Thr Tyr Arg Arg 
        195                 200                 205             


His Gly Asp Val Ala Lys Ala Ile Arg Val Ala Ala Glu Val Ala Glu 
    210                 215                 220                 


Lys Glu Lys Arg Lys Val Gly Trp Arg Leu Ala Ala Ala Glu Ile Tyr 
225                 230                 235                 240 


Val His Phe Gly Lys Val Phe Thr Asn Gly Gly Arg Met Leu Ser Phe 
                245                 250                 255     


Ala Glu Ala Glu Thr Lys His Pro Gly Leu Thr Gly Leu His Arg Ala 
            260                 265                 270         


Ile Glu Asp Leu Tyr Arg Gln Arg Leu Lys Arg His Leu Lys Asp Pro 
        275                 280                 285             


Lys Leu His Ala Ser Gln Pro Gly Thr Glu Arg Leu Val Ser Val Ile 
    290                 295                 300                 


Leu Pro Glu Asp Phe Asp Ser Leu Leu Arg Ala Leu Gly Asn Arg Arg 
305                 310                 315                 320 


Gln Asn Arg Asp Ile Gly Ala Leu Ile Arg Lys Gly Arg Ile Leu His 
                325                 330                 335     


Tyr Glu Ala Gly Ala Arg Val Asn Arg Asp Asp Val Ala Trp Ile Asn 
            340                 345                 350         


Gln His Trp Pro Asp Asp Thr Thr Lys Ser Arg Tyr Trp Thr Ser Asp 
        355                 360                 365             


Gly Gln Thr Glu Ile Lys Arg His Glu Ile Phe Val Arg Ile Trp Arg 
    370                 375                 380                 


Ser Ala Leu Ala His Ala Asn Arg Thr Leu Ala Asp Trp Leu Asp Pro 
385                 390                 395                 400 


Asp Gly Lys Ala Thr Asp Ile Ala Glu Gly Gly Asn Thr Phe Glu Gln 
                405                 410                 415     


Val Leu Ala Ala Thr Gly Gln Ala Thr Val Val Gln Thr Ala Asn Leu 
            420                 425                 430         


Phe Gly Ser Arg Ala Ala Ala Leu Glu Ser His Glu Ala Ile Gln Asp 
        435                 440                 445             


Leu Ala Arg Leu Val Trp Thr Val Tyr Thr Gln Leu Arg His Asn Ser 
    450                 455                 460                 


Phe His Phe Lys Gly Val Asp Gly Phe Lys Val Ala Leu Thr Pro Lys 
465                 470                 475                 480 


Leu Ala Glu Ile Ala Pro Gly Ala Leu Gln Phe Thr Thr Asn Leu Leu 
                485                 490                 495     


Arg Gly Asp Phe Arg Asp Ser Glu Ala Arg Leu Arg Ala Val Leu Arg 
            500                 505                 510         


Ala Ala Gln Val Glu Gly Phe Leu Asp Arg Gly Arg Leu Ala Glu Ile 
        515                 520                 525             


Trp Ala Ala Leu His Pro Ala Gly Glu Ala Gly Leu Gly Pro Ala Leu 
    530                 535                 540                 


Pro Arg Phe Asn Arg Ile Val Gln Arg Val Asp Gly Thr Gly Ala Ile 
545                 550                 555                 560 


Ala Glu Leu Pro Cys Ala Val Asn Gln Phe Asp Met Ala Asn Pro Ala 
                565                 570                 575     


Ile His Cys Arg Tyr Val Val Thr Lys Leu Leu Tyr Glu Arg Gly Phe 
            580                 585                 590         


Arg Ala Trp Val Ala Met Ala Thr Thr Asp Gln Ile Asn Ala Trp Ile 
        595                 600                 605             


Lys Ser Ala Glu Asp Arg Thr Gln Lys Ala Lys Asp Glu Ile His Gly 
    610                 615                 620                 


His Pro Glu Asp Lys Ala Arg Met Val Gly Ala Leu Arg Leu Arg Asp 
625                 630                 635                 640 


Gly Gln Gly Ile Met Asp Phe Leu Ser Glu Leu Thr Ala Leu Thr Ala 
                645                 650                 655     


Thr Glu Phe Arg Val Gln Ala Gly Tyr Glu Pro Asn Arg Ala Ala Ala 
            660                 665                 670         


Gln Glu Gln Ala Glu Tyr Leu Phe His Leu Gln Cys Asp Val Leu Ala 
        675                 680                 685             


Leu Ala Phe Lys Glu Tyr Ile Arg Ala Ala Arg Leu Gly Trp Leu Ser 
    690                 695                 700                 


Asp Thr Leu Lys Pro Asp Arg Val Ala Arg Gly Val Leu Ser Asp Val 
705                 710                 715                 720 


Asp Lys Leu Ala Asp Pro Lys Ala Thr Pro Asp Phe Glu Asp Trp Gln 
                725                 730                 735     


Ala Gly Ile Tyr Ala Val Leu His Leu Val Pro Val Asp Glu Val Gly 
            740                 745                 750         


Arg Leu Leu His Gln Leu Arg Arg Trp Ala Asn Gly Gln Pro Ala Asp 
        755                 760                 765             


Glu Thr Ser Val Lys Ile Glu Arg Leu Leu Glu Leu Tyr Leu Asp Met 
    770                 775                 780                 


His Asp Asp Lys Phe Glu Gly Gly Gly Pro Leu His Asp His Pro Asp 
785                 790                 795                 800 


Leu Gln Ala Leu Phe Glu Thr Pro Asp Leu Leu Ala Gln Val Leu Pro 
                805                 810                 815     


Gln Val Gly Ala Thr Glu Asp Glu Arg Arg Arg Val Pro Leu Arg Gly 
            820                 825                 830         


Leu Arg Glu Met Leu Arg Phe Gly Asn Leu Arg Ile Leu Lys Gly Val 
        835                 840                 845             


Phe Ala Lys Ala Pro Ile Thr Thr Ala Gly Val Ala Lys Leu Ala Glu 
    850                 855                 860                 


Tyr Glu Lys Ser Arg Ala Asp Gly Leu Gly Gly Ile Asp His Ala Gln 
865                 870                 875                 880 


Gln Ile Arg Gln Lys Arg His Glu Thr Leu Ala Lys Leu Arg Met Leu 
                885                 890                 895     


Gly Pro Asp Ser Tyr Gly Asp Val Arg Asp Tyr Leu Phe Val Thr Lys 
            900                 905                 910         


Arg Ile Ile Arg His Arg Arg Leu Ala Asn His Val Arg Leu Val Asn 
        915                 920                 925             


His Val Arg Val Asn Gln Ile Leu Met Ser Val Leu Gly Arg Phe Ala 
    930                 935                 940                 


Asp Cys Ala Gly Leu Phe Glu Arg Asp Leu Tyr Phe Thr Leu Leu Ala 
945                 950                 955                 960 


Leu Ile His Glu Leu Gly Gln Lys Pro Glu Ala Gly Phe Asp Ala Lys 
                965                 970                 975     


Ala Leu Gly Lys Phe Glu Asp Gly Gln Ile Leu Thr Ala Leu Asp Arg 
            980                 985                 990         


Asn Lys Thr Pro Leu Pro Ala Ser  Ile Ala Cys Glu Leu  Gln Arg His 
        995                 1000                 1005             


Phe Gly  Leu Asp Ala Lys Gly  Ala Gly Pro Asn Arg  Lys Arg Arg 
    1010                 1015                 1020             


Asn Asp  Phe Ala His Phe Asn  Leu Leu Arg Ser Lys  Thr Pro Ile 
    1025                 1030                 1035             


Asn Leu  Thr Ala Ala Met Asn  Asp Ala Arg Ala Leu  Leu Ser His 
    1040                 1045                 1050             


Asp Arg  Lys Leu Lys Asn Ala  Val Ser Ala Ser Ile  Val Thr Leu 
    1055                 1060                 1065             


Leu Glu  Arg Glu Gln Ile Val  Ala His Trp Asn Met  Gly Thr Asp 
    1070                 1075                 1080             


His Gln  Leu Ala Asp Ala Val  Ile Gly Thr Arg Arg  Ile Val His 
    1085                 1090                 1095             


Leu Lys  Ser Ala Glu Leu Ala  Glu Asn Leu Arg Asp  Lys Arg Phe 
    1100                 1105                 1110             


Leu Thr  Leu Ile Ala Gln Leu  Phe Asn Gly Arg Val  Asn Asn Leu 
    1115                 1120                 1125             


Pro Asp  Asp Ile Ala Ala Leu  Asp Arg Pro Gly Ile  Glu Ala Leu 
    1130                 1135                 1140             


Ala Ala  Arg Val Thr Gly Gly  Gly Gly Arg 
    1145                 1150             


<210>  1253
<211>  1165
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1253

Met Gly Ser Gly Lys Tyr Arg Ile Thr Lys Ile Ala Arg Lys Trp Asp 
1               5                   10                  15      


Lys Asn Glu Asn Trp Glu Lys Ile Ile Leu Lys Arg Ile Val Asp Asn 
            20                  25                  30          


Lys Lys Ile Lys Tyr Val Asn Glu Asn Asn Asn Lys Asp Val Asp Ile 
        35                  40                  45              


Thr Asp Thr Tyr Tyr Ser Ile Leu Ser Lys Asn Asn Ser Lys Phe Leu 
    50                  55                  60                  


Gly Ser Glu Glu Gln Phe Ile Phe Lys Val Asn Lys Met Lys Arg Asn 
65                  70                  75                  80  


Ile Lys Asn Asp Cys Val Ile Ile Lys Asp Tyr Thr Glu Glu Glu Phe 
                85                  90                  95      


Glu Lys Phe Asp Lys Lys Ile Phe Phe Ser Arg Lys Ile Lys Val Asn 
            100                 105                 110         


Asn Glu Asp Arg Glu Lys Ile Cys Arg Asn Phe Tyr Glu Asp Glu Arg 
        115                 120                 125             


Glu Ile Met Lys Lys Arg Leu Glu Glu Ala Lys Asn Phe Asn Asn Ile 
    130                 135                 140                 


Ile Phe Asn Ile Cys Asn Lys Ile Phe Lys Leu Glu Tyr Ile Asp Tyr 
145                 150                 155                 160 


Thr Asp Glu Lys Val Tyr Glu Ile Phe Gln Lys Glu Ile Lys Phe Glu 
                165                 170                 175     


Asp Ile Lys Asn Leu Lys Glu Ala Phe Lys Gln Gln Glu Asn Gly Leu 
            180                 185                 190         


Glu Thr Asp Lys Leu Leu Thr Ile Ser Phe Asn Lys Lys Arg Ser Asn 
        195                 200                 205             


Val Leu Leu Glu Phe Ile Gln Gln Ile Val Lys Gln Asn Phe Glu Asn 
    210                 215                 220                 


Glu Lys Glu Leu Glu Asn Trp Phe Ser His Asp Gly Glu Lys Tyr Cys 
225                 230                 235                 240 


Lys Glu Ile Phe Lys Ile Tyr Ser Asn Met Ser Gln Lys Glu Lys Tyr 
                245                 250                 255     


Ser Lys Leu Leu Gly His Asn Asp Glu Ser Ile Ala Ser Asp Ser Glu 
            260                 265                 270         


Lys Arg Glu Thr Leu Gln Arg Arg Leu Lys Leu Gly Asp Tyr Ser Lys 
        275                 280                 285             


Tyr Asp Leu Lys Lys Tyr Tyr Gln Lys Asp Tyr Lys Glu Glu Ala Ile 
    290                 295                 300                 


Lys Glu Leu Glu Asp Lys Ser Lys Glu Glu Leu Glu Lys Glu Val Glu 
305                 310                 315                 320 


Glu Ile Ile Lys Lys Asn Tyr Lys Ile Asp Lys Leu Cys Asp Glu Ile 
                325                 330                 335     


Ser Asn Leu Glu Phe Ser Phe Val Asp Ser Lys Lys Glu Asn Lys Asp 
            340                 345                 350         


Lys Met Ser Glu Ile Ile Val Lys Ile Lys Glu His Tyr Lys Asn Asn 
        355                 360                 365             


Val Asn Val Glu Glu Glu Leu Glu Asn Lys Glu Lys Tyr Ile Leu Ser 
    370                 375                 380                 


Met Ile His Asn Tyr Ile Lys Gly Arg Tyr Arg Lys Cys Leu Glu Leu 
385                 390                 395                 400 


Gln Gln Lys Glu Asn Val Asp Phe Glu Asn Leu Gly Lys Arg Ile Lys 
                405                 410                 415     


Glu Ile Phe Asp Ser Asn Lys Val Thr Glu Lys Leu Lys Lys Ser Ile 
            420                 425                 430         


Leu Asn Lys Val Asn Asn Tyr Lys Ile Phe Glu Thr Lys Phe Gln Asn 
        435                 440                 445             


Pro Asn Ile Glu Ser Ser Asp Asp Leu Glu Ile Leu Lys Ala Glu Glu 
    450                 455                 460                 


Thr Phe Leu Asn Lys Leu Ser Thr Ala Val Ser Lys Val Gly Tyr Ile 
465                 470                 475                 480 


Leu Asn Ile Leu Leu Glu Ile His Phe Arg Asn Asp Ile Leu Gln Asp 
                485                 490                 495     


Tyr Asn Gln Val Glu Lys Leu Trp Lys Ser Asp Ser Phe Gln Lys Ile 
            500                 505                 510         


Cys Ala Ile Tyr Pro Glu Ile Asn Asn Asp Glu Lys Leu Leu Lys Gly 
        515                 520                 525             


Met Ile Tyr Phe Ile Gln Gly Leu Arg Gln Gln Val Leu His Pro Lys 
    530                 535                 540                 


Ile Leu Trp Glu Lys Gln Asn Ile Tyr Asn Ala Glu Asn Ile Lys Glu 
545                 550                 555                 560 


Lys Glu Lys Ile Val Ser Val Arg Leu Gln Asn Glu Gly Glu Ala Tyr 
                565                 570                 575     


Asn Lys Lys Gly Ile Gln Asn Tyr Phe Glu Asn Val Leu Lys Lys Ile 
            580                 585                 590         


Pro Asp Tyr Phe Ile Glu Lys Tyr Glu Ser Asn Asn Val Phe Asn Ile 
        595                 600                 605             


Tyr Arg Asn Phe Val Asp Lys Ile Met Glu Val Val Lys Asn Phe Asn 
    610                 615                 620                 


Phe Lys Glu Asn Asn Thr Ile Asp Tyr Leu Phe Pro Lys Phe His Lys 
625                 630                 635                 640 


Ile Tyr Lys Arg Met Cys Lys Leu Glu Asn Ile Asp Asp Arg Gln Asn 
                645                 650                 655     


Gly Ala Arg Lys Tyr Leu Leu Gln Ile Ile Tyr Tyr Tyr Tyr Phe Gln 
            660                 665                 670         


Tyr Glu Ile Glu Asn Asp Lys Asn Asn Ile Ser Lys Tyr Leu Asn Leu 
        675                 680                 685             


Tyr Arg Asn Lys Ile Lys Val Lys Lys Ile Ser Tyr Ser Tyr Ile Thr 
    690                 695                 700                 


Asp Asn Lys Ala Val Asn Asn Lys Asn Ile Glu Ile Leu Tyr Arg Asn 
705                 710                 715                 720 


Ile Gln Arg Glu Gly Met Leu Asn Asn Lys Leu Ser Gln Met Asn Lys 
                725                 730                 735     


Glu Trp Ile Glu Phe Ile Val Val Gln Phe Ser Glu Phe Leu Thr Asn 
            740                 745                 750         


Lys Lys Leu Asn Trp Ile Leu Asp Asn Leu Ser Glu Tyr Lys Lys Lys 
        755                 760                 765             


Glu Lys Leu Asp Glu Asn Asp Lys Asn Arg Leu Leu Lys Ile Leu Lys 
    770                 775                 780                 


Gln Lys Met Asn Lys Lys Ile Ile Tyr Ser Asn Asp Ser Tyr Ala Phe 
785                 790                 795                 800 


Ile Ser Leu Ala Gln Phe Leu Asp Leu Lys Glu Ile Ser Asn Leu Ile 
                805                 810                 815     


His Asp Ile Lys Lys Phe Ile Gln Phe Arg Glu Lys Asn Val Ser Lys 
            820                 825                 830         


Tyr Lys Pro Glu Lys Asn Lys Leu Tyr Ile Lys Glu Leu Arg Lys Val 
        835                 840                 845             


Leu Tyr Ile Leu Lys Val Met Leu Glu His Lys Glu Arg Val Ile Gln 
    850                 855                 860                 


Lys His Tyr Leu Glu Ser Tyr Asp Glu Asn Ile Ser Ile Ile Tyr Gly 
865                 870                 875                 880 


Lys Asp Ile Glu Arg Lys Asp Ile Lys Asp Ile Lys Ile Lys Ile Lys 
                885                 890                 895     


Asn Glu Asn Gln Glu Val Ile Asn Gln Pro Leu Tyr Lys Ser Gly Asn 
            900                 905                 910         


Asp Glu Asn Ser Ser Trp Ile Val Leu Tyr Gly Ile Glu Gln Ala Lys 
        915                 920                 925             


Arg Asn Gly Thr Phe Lys Phe Phe Glu Gly Phe Phe Asn Leu Asn Asp 
    930                 935                 940                 


Asp Ile Lys Leu Cys Lys Glu Asn Ile Glu Lys Tyr Glu Glu Leu Tyr 
945                 950                 955                 960 


Asn Glu Lys Glu Glu Asn Gln Arg Lys Val Asp Glu Tyr Ile Ser Ser 
                965                 970                 975     


Glu Glu Asn Asn Asn Ile Asp Glu Ile Lys Glu Ile Asn Asn Asn Lys 
            980                 985                 990         


Gln Leu Phe Tyr Tyr Tyr Lys Asn  Met Ile Tyr Gly Asp  Gly Leu Lys 
        995                 1000                 1005             


Lys Gly  Tyr Asp Phe Ile Asn  Asp Ile Tyr Ser His  Tyr Leu Ser 
    1010                 1015                 1020             


Trp Ala  Tyr Arg Val Glu Arg  Asp Cys Lys Ile Tyr  Lys Ile Lys 
    1025                 1030                 1035             


Glu Tyr  Glu Asn Lys Lys Asn  Phe Asn Glu Tyr Lys  Phe Lys Glu 
    1040                 1045                 1050             


Tyr Lys  Ser Ile Lys Asn Phe  Arg Asn Glu Ile Ala  His Phe Asn 
    1055                 1060                 1065             


Tyr Phe  Gln Lys Thr Asn Lys  Ser Leu Leu Glu Leu  Leu Asn Asp 
    1070                 1075                 1080             


Phe Tyr  Asp Ile Phe Asp Tyr  Asn Leu Lys Tyr Gln  Arg Asp Val 
    1085                 1090                 1095             


Gln Asn  Val Ile Asn Asn Ile  Phe Glu Lys Tyr Gln  Ile Val Arg 
    1100                 1105                 1110             


Lys Asp  Gly Gly Pro Val Val  Phe Tyr Cys Lys Thr  Asp Lys Lys 
    1115                 1120                 1125             


Leu Lys  Leu Ser Glu Asn Leu  Val Pro Lys Lys His  Ser Lys Tyr 
    1130                 1135                 1140             


Pro Glu  Ile Lys Leu Ile His  Glu Lys Tyr Val Met  Phe Phe Arg 
    1145                 1150                 1155             


Lys Leu  Phe Glu Tyr Lys Lys  
    1160                 1165 


<210>  1254
<211>  1360
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1254

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp Arg  Ser Met Met Asp Leu  Tyr Ser Glu 
    1235                 1240                 1245             


Ile Tyr  Asp Arg Phe Phe Arg  His Asp His Asn Arg  Lys Lys Asn 
    1250                 1255                 1260             


Val Pro  Asp Ser Leu Lys Asn  Val Leu Ala Asp Asn  Phe Met Ile 
    1265                 1270                 1275             


Val Asp  Ile Asp Met Glu Leu  Gly Ser Lys Lys Val  Gly Glu Lys 
    1280                 1285                 1290             


Lys Lys  Gly Phe Arg Glu His  Lys Ala Ala Arg Ile  Glu Phe Thr 
    1295                 1300                 1305             


Asp Ser  Gly Ile Arg Ser Thr  Asp Met Thr Tyr Thr  Ile Lys Pro 
    1310                 1315                 1320             


Asp Ile  Lys Asp Asn Lys Lys  Asp Lys Lys Val Leu  Val Pro Ala 
    1325                 1330                 1335             


Arg Ser  Glu Val Phe Leu Lys  Gln Phe Arg Lys Ile  Leu Glu Tyr 
    1340                 1345                 1350             


Arg Ile  Gln Asp Lys Ile Gln  
    1355                 1360 


<210>  1255
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1255

Met Lys Leu Thr Gln Ser Arg Gln Ser Lys Gly Ala Gln Phe Phe Arg 
1               5                   10                  15      


Asp Val Ser Lys Gly Gln Leu Val Leu Asn Asn Asn Ile Asp Asn Thr 
            20                  25                  30          


Asp Asn Val Ile Gln Ser Leu Pro Tyr Glu Lys Ser Tyr Ile Gly Arg 
        35                  40                  45              


Ile Leu Tyr Lys Ser Ser Asn Ser Asp Lys Asp Asn Asp Gln Asn Pro 
    50                  55                  60                  


Phe Asn Ser Phe Val Arg Gln Leu Val Lys Asn Gln Asn Lys Glu Arg 
65                  70                  75                  80  


Lys Leu Thr Ser Tyr Ile Asn Leu Asn Asp Lys Asn Asn Lys Lys Leu 
                85                  90                  95      


Ser Lys Asp Asp Phe Lys Asn Gln Ile Asn Thr His Leu Ser Phe Tyr 
            100                 105                 110         


Gly Arg Asn Leu Lys Val Asp Ala Asp Ser Pro Thr Leu Lys Glu Ile 
        115                 120                 125             


Leu Leu Gln Tyr Tyr Asp Gly Asn Asn Asp Ala Glu Asn Glu Leu Lys 
    130                 135                 140                 


Lys Leu Ala Asn Tyr Ile Ser Asn Leu Ala Lys Lys Lys Thr Glu Lys 
145                 150                 155                 160 


Leu Lys Lys Ser Ile Lys Asn Asn Lys Ile Pro Phe Glu Pro Asp Gly 
                165                 170                 175     


Glu Lys Leu Lys Leu Thr Ser Asp Lys Met Lys Leu Leu Phe Asp Phe 
            180                 185                 190         


Leu Lys Lys Asp Gly Val Glu Leu Thr Ser Tyr Glu Lys Phe Gln Lys 
        195                 200                 205             


Asp Tyr Lys Phe Ser Asp Leu Ala Asn Lys Ile Glu Ser Ile Ile Ser 
    210                 215                 220                 


Asn Asp Lys Asn Ser Val Asp Lys Lys Pro Phe Pro Thr Lys Lys Ile 
225                 230                 235                 240 


Tyr Gln Thr Val Ser Asp Tyr Asp Tyr Asp Phe Arg Lys Lys Asn Glu 
                245                 250                 255     


Asp Asn Asp Leu Tyr Leu Phe Tyr Ala Lys Glu Val Lys Asn Tyr Phe 
            260                 265                 270         


Lys Arg Leu Phe Ile Asp Lys Lys Leu Ser Lys Lys Gln Tyr Glu Glu 
        275                 280                 285             


Ile Lys Ser Gln Asn Tyr Lys Ser Glu Lys Tyr Ile Phe Gly Gln Val 
    290                 295                 300                 


Lys Arg Tyr Ile Ile Asn Gln Leu Val Gln Gly Leu Ile Leu Tyr Gly 
305                 310                 315                 320 


Lys Ile Met His Tyr Cys Tyr Asp Thr Asp Ala Lys Gln Phe Asn Val 
                325                 330                 335     


Glu Ile Asn Ser Asp Thr Leu Thr Tyr Ile Gln Val Glu Glu Ala Phe 
            340                 345                 350         


Lys Lys Gln Ile Tyr Leu Ser Leu Ser Trp Ala Ile Thr Arg Leu Asn 
        355                 360                 365             


Tyr Phe Phe Asn Tyr Gly Ser Gln Asn Glu Glu Asn Leu Asp Lys Asp 
    370                 375                 380                 


Lys Lys Glu Gly Asp Ile Leu Leu Ala Lys Thr Phe Arg Asp Lys Phe 
385                 390                 395                 400 


Tyr Glu Lys Val Phe Asn Asn Asn Glu Lys Asp Asp Asp Gly Ile Ser 
                405                 410                 415     


Pro Lys Asp Glu Leu Tyr Ala Lys Ile Ser Thr Cys Phe Ala Ile Asn 
            420                 425                 430         


Ser Lys Asp Asn Asn Asp Asp Asp Ile Lys Lys Leu Leu Glu Asp Cys 
        435                 440                 445             


Cys Ser Ser Val Ala Asn Ile Arg His Asn Val Phe His Phe Lys Lys 
    450                 455                 460                 


Glu Asn Ile Phe Glu Ile Leu Glu Glu Ile Lys Leu Asp Ser Gln Ile 
465                 470                 475                 480 


Ser Lys Glu Leu Leu Asn Arg Asp Ile Leu Asn Ile Gln Lys Cys Phe 
                485                 490                 495     


Lys Glu Gln Ile Arg Ser Thr Ala Leu Thr Asp Tyr Tyr Ser Phe Glu 
            500                 505                 510         


Leu Leu Glu Lys Val Phe Lys Asn Glu Lys Leu Glu Phe Phe Leu Tyr 
        515                 520                 525             


Ser Ser Gln Tyr Pro Met Met Pro Ser Phe Lys Lys Ile His Lys Arg 
    530                 535                 540                 


Gly Cys Asn Ile Ser Lys Ser Pro Asn Gln Thr Lys Glu Ile Lys Trp 
545                 550                 555                 560 


Leu Ile Glu Leu Asp Ser Glu Ile Asp Asn Glu Gly Lys Leu Ala Tyr 
                565                 570                 575     


Lys Asn Leu Leu Gln Leu Ile Tyr Tyr His Ser Phe Leu Pro Ala Ile 
            580                 585                 590         


Lys Lys Asp Glu Lys Leu Val Thr Glu Phe Ile Asn Lys Thr Lys Gln 
        595                 600                 605             


Trp Asn Lys Thr Lys Ser Ile Ala Ser Gln Lys Ala Lys Lys Ala Lys 
    610                 615                 620                 


Asn Lys Lys Ile Asn Tyr Tyr Glu Phe Lys Tyr Ser Asn Met Pro Arg 
625                 630                 635                 640 


Phe Glu Tyr Gly Ile Pro Leu Lys Asp Tyr Leu Glu Glu Leu Gln Arg 
                645                 650                 655     


Gln Gln Ser Ile Arg Glu Asn Asp Glu Asp Lys Lys Asp Lys Asp Asn 
            660                 665                 670         


Tyr Tyr Val Glu Phe Val Gln Asp Ile Phe Val Phe Ala Phe Asp Ser 
        675                 680                 685             


Tyr Leu Leu Lys Ile Ile Ser Ala Tyr Asp Cys Tyr Glu Glu Leu Ile 
    690                 695                 700                 


His Pro Lys Leu Lys Thr Lys Glu Glu Ser Lys Glu Thr Leu Glu Lys 
705                 710                 715                 720 


Leu Phe Asn Glu Ser Asn Pro Ile Leu Lys Ile Lys Thr Asn Leu Asn 
                725                 730                 735     


Pro Asp Thr Lys Phe Ile Thr Met Tyr Pro Phe Phe Arg Leu Leu Asp 
            740                 745                 750         


Gln Arg Glu Leu Asn Ile Leu Leu His Gln Phe Ile Arg Tyr Cys Ser 
        755                 760                 765             


Ser Thr Gln Lys Arg Ser Asn Thr Asn Asp Glu Thr Leu Asn Thr Leu 
    770                 775                 780                 


Thr Gln Ile Glu Glu Leu Ile Thr Leu Val Gln Phe Thr Ile Pro Leu 
785                 790                 795                 800 


Gln Thr Lys Asp Val His Phe Lys Ser Ala Met Glu Lys Tyr Phe Ser 
                805                 810                 815     


Glu Phe Phe Glu Asn Lys Asp Pro Gln Asn Tyr Asp Asp Phe Tyr Leu 
            820                 825                 830         


Gln Gly Ser Lys Lys Glu Glu Asp Lys Leu Val Lys His Arg Ser Met 
        835                 840                 845             


Ser Leu Val Ala Arg Ser Gly Ala Met Ala Leu Tyr Thr Lys Met Phe 
    850                 855                 860                 


Ser Ser Ile Tyr Gln Ile Asn Lys Ser Asp Tyr Glu Lys Tyr Lys Asp 
865                 870                 875                 880 


Ile Tyr Thr Ile Lys Asn Asn Ser Glu Val Thr Lys Ile Glu Glu Met 
                885                 890                 895     


Gln Asn Arg Leu Gln Gln Leu His Glu Lys Leu Val Arg Ile Lys Leu 
            900                 905                 910         


Ile Ser Asp Thr Gln Leu Asn Asp Ile Lys Lys Tyr Gln Thr Leu Ala 
        915                 920                 925             


Lys Gln Ile Lys Glu Tyr Glu Asn Leu Arg His Lys Leu Thr Phe Glu 
    930                 935                 940                 


Ser Leu Tyr Arg Ile His Gln Leu His Val Glu Ile Leu Gly Arg Phe 
945                 950                 955                 960 


Ala Ala Phe Ala Asn Asp Trp Glu Arg Asp Met Phe Phe Met Phe Thr 
                965                 970                 975     


Ala Leu Glu Asn Arg Gly Lys Ile Asn Phe Lys Leu Lys Pro Ile Phe 
            980                 985                 990         


Asn Arg Gly Lys Val Val Gly Asn  Leu Asn Asn Lys Leu  Lys Asp Asp 
        995                 1000                 1005             


Ala Arg  Lys Leu Phe Phe Glu  Leu Cys Trp Ser Asn  Glu Ile Tyr 
    1010                 1015                 1020             


Asp Lys  Asp Lys Asp Asp Asn  Ser Asn Gly Asp Tyr  Ile Tyr Asp 
    1025                 1030                 1035             


Arg Leu  Leu Ile Arg Asn Tyr  Cys Ala His Leu Asn  His Met Thr 
    1040                 1045                 1050             


Gln Phe  Lys Lys Asn Asn Glu  Thr Gln Pro Ser Ile  Ile Gly Tyr 
    1055                 1060                 1065             


Ile Asn  Lys Leu Arg Val Leu  Leu Ala Tyr Asp Ile  Lys Arg Gln 
    1070                 1075                 1080             


Asn Ala  Val Thr Lys Ala Val  Lys Glu Ile Leu Glu  Lys His Tyr 
    1085                 1090                 1095             


Lys Val  Lys Leu Thr Leu Lys  Arg Ser Asp Asp Asn  Pro Asp Lys 
    1100                 1105                 1110             


Phe Val  Ile Ala Asn Leu Glu  Ser Asp Glu Ile Thr  His Leu Lys 
    1115                 1120                 1125             


Asn Leu  Lys Asn Pro Val Ile  Ile Glu Asp Asn Asp  Lys Phe Met 
    1130                 1135                 1140             


Ile Ser  Leu Ile Arg Lys Leu  Leu Ile Phe Lys Phe  Glu Ser Ala 
    1145                 1150                 1155             


Asn Val  Lys 
    1160     


<210>  1256
<211>  1197
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1256

Met Gln Ile Ile Lys Pro Tyr Gly Arg Ser His Val Glu Glu Asn Arg 
1               5                   10                  15      


Ala Ala Gly Thr Arg Arg Val Leu Ser Leu Arg Leu Asp Pro Glu Lys 
            20                  25                  30          


Arg Met Asp Ile Val Glu Phe Ala Arg Ser His Glu Lys Leu Val Val 
        35                  40                  45              


Ala Gln Trp Ile Ser Thr Ile Asp Lys Ile Ala Ser Lys Pro Ala Gly 
    50                  55                  60                  


Glu Asn Gly Pro Thr Glu Glu Gln Arg Ala Phe Arg Gln Arg Leu Gly 
65                  70                  75                  80  


Asp Ala Ala Trp Thr Leu Leu Glu Ala Lys Gly Leu Leu Pro Gly Val 
                85                  90                  95      


Lys Gln Pro Glu Val Lys Gln Gln Leu Ala Lys Leu Trp Lys Val Lys 
            100                 105                 110         


Ile Ala Pro Tyr Gly Thr Ala Arg Tyr Arg Ala Glu Lys Asn Arg Lys 
        115                 120                 125             


Pro Pro Ser Val Arg Gly Arg Trp Tyr Asp His Phe Ser Glu Gly Val 
    130                 135                 140                 


Ala Asp Val Ala Asn Val Asp Ala Ala Glu Val Ala Lys Lys Ile His 
145                 150                 155                 160 


Glu His Leu Tyr Ile Ala Gly Tyr Arg Ile Gly Thr Gly Val Arg Asn 
                165                 170                 175     


Arg Arg Gln Gly His Ile Ala Ala Arg Ala Lys Ser Ile Ala Val Asn 
            180                 185                 190         


Val Leu Arg Thr Gly Leu Pro Ala Tyr Gly Gly Gly Val Gly Ala Gly 
        195                 200                 205             


Trp Met Ala Glu Asp Arg Asp Ser Tyr Ala Lys Ala Gly Asn Phe Val 
    210                 215                 220                 


Gln Glu Ile Arg Leu Ala Ala Glu Arg Arg Glu Arg Gly Glu Asp Lys 
225                 230                 235                 240 


Ala Gly Thr Leu Arg Val Thr Ser Ser Ile Ala Gly Lys Ala Leu Phe 
                245                 250                 255     


Glu His Tyr Ala Arg Leu Phe Lys Arg Ala Asp Gly Lys Ala Leu Ser 
            260                 265                 270         


Ile Arg Glu Ala Arg Glu Arg Thr Pro Gly Leu Phe Asn Leu His Met 
        275                 280                 285             


Ala Val Lys Asp Cys Tyr Ser Arg Ile Leu Lys Asn His Lys Lys Asp 
    290                 295                 300                 


Leu Lys Ala His Gly Asp Arg Arg Arg Lys Val Ser Ala Leu Leu Pro 
305                 310                 315                 320 


Ser Thr Met Asp Gly Leu Phe Ala Leu Leu Asp Ala Lys Arg Thr Asn 
                325                 330                 335     


Arg Asp Leu Asn Thr Leu Val Arg Leu Gly Lys Val Ile His Tyr Lys 
            340                 345                 350         


Ser Ser Gly Gly Val Glu Asp Trp Pro Ser Asp Pro Val His Asn Trp 
        355                 360                 365             


Pro Ala Asp Val Thr Arg Ser Phe Phe Trp Thr Ser Asp Gly Gln Ala 
    370                 375                 380                 


Ile Met Lys Arg Asn Glu Ala Phe Val Arg Val Trp Arg His Val Leu 
385                 390                 395                 400 


Ala Leu Ala Ser Arg Thr Leu Thr Asp Trp Ala Asp Pro Asp Gly Lys 
                405                 410                 415     


Ile Arg Ser Asp Ile Leu Leu Ser Gly Pro Ile Glu Arg Ala Thr Gly 
            420                 425                 430         


Asp Cys Phe Asp Asn Gly Asn Tyr Ala Arg Lys Leu Ala Leu Leu Phe 
        435                 440                 445             


Gly Ser Arg Ala Asp Ile Phe Gln Cys Ala Gly Asp Asp Ala Val Gln 
    450                 455                 460                 


Lys Asn Val Leu Arg His Ala Leu Glu Gly Ile Ala Gly Leu Arg His 
465                 470                 475                 480 


Ser Ser Phe His Phe Lys Gly Leu Gly Gly Phe Ala Asp Ala Leu Thr 
                485                 490                 495     


Arg Ser Gln Phe Ala Leu Asp Glu Asn Val Ile Gly Ala Val Arg Gln 
            500                 505                 510         


Leu Trp Gln Ala Asp Val Gly Gly Arg Ala Gly Gln Leu Leu Lys Thr 
        515                 520                 525             


Met Arg Ala Ala His Phe Glu Tyr Phe Leu Gly Glu Ser Gln Asn Arg 
    530                 535                 540                 


Lys Leu Leu Ala Val Leu Ser Asn Ala Glu Ser Ala Leu Ile Pro Leu 
545                 550                 555                 560 


Pro Arg Phe Ser Lys Met Leu Glu Arg Ala Gln Asn Ala Trp Arg Asp 
                565                 570                 575     


Gly Lys Asp Gly Leu Arg Leu Pro Lys Pro Ala Asn Arg Thr Asp Arg 
            580                 585                 590         


Glu Asn Pro Ala Arg Leu Cys Gln Tyr Ala Ala Leu Lys Leu Leu Tyr 
        595                 600                 605             


Glu Arg Ala Phe Arg Asn Trp Leu Tyr Glu Arg Ser Ala Glu Ser Leu 
    610                 615                 620                 


Asn Arg Phe Ile Asp Arg Ala Val Glu Arg Ala Thr Ala Ala Ala Arg 
625                 630                 635                 640 


Asp Leu Asn Ala Arg Asp Asp Glu Asp Arg Arg Asp Ile Ile Val Ala 
                645                 650                 655     


Lys Ala Ala Thr Leu Gly Arg Leu Ala Asp Gly Glu Thr Val Glu Thr 
            660                 665                 670         


Phe Phe Phe Lys Leu Ser Ala Gln Thr Ala Ser Glu Met Arg Val Gln 
        675                 680                 685             


Arg Gly Tyr Asp Ser Asp Ala Asp Arg Ala Arg Glu Gln Ala Gly Tyr 
    690                 695                 700                 


Ile Glu Asn Leu Lys Ser Asp Val Val Val Leu Ala Phe Gly Ala Tyr 
705                 710                 715                 720 


Leu Lys Glu Ala Ser Phe Asp Phe Leu Leu Lys Leu Ser Pro Asp Ala 
                725                 730                 735     


Pro Lys Pro Glu Lys Pro Leu Cys Ile Leu Asp Gly Met Arg Arg Asp 
            740                 745                 750         


Glu Gly Asp Arg Pro Ala Glu Asn Trp Gln Met Thr Leu Tyr Phe Leu 
        755                 760                 765             


Ile His Leu Val Pro Val Asp Glu Ile Gly Lys Leu Leu His Gln Met 
    770                 775                 780                 


Arg Lys Trp Glu Ser Leu Ala Ala Lys Pro Val Met Ala Asp Pro Asp 
785                 790                 795                 800 


Arg Arg Gln Leu Asp Lys Ser Thr Ile Ala Asp Asn Val Arg Lys Val 
                805                 810                 815     


Gln Ser Val Leu Glu Leu Tyr Leu Asp Met His Asp Ala Lys Phe Asp 
            820                 825                 830         


Gly Glu Ala Ala Leu Ile Gly Thr Gly Ala Phe Lys Lys Leu Tyr Glu 
        835                 840                 845             


Pro Glu Asp Leu Phe Asp Arg Ile Phe Pro Arg Gln Phe Gly Ala Asp 
    850                 855                 860                 


Asp Asp Arg Arg Ile Pro Arg Arg Gly Leu Arg Glu Ile Met Arg Phe 
865                 870                 875                 880 


Gly His Leu Gln Val Leu Arg Pro Val Phe Gln Lys His Pro Ile Gln 
                885                 890                 895     


Leu Ala Lys Val Glu Lys Phe Phe Ala Ala Glu Glu Arg Gln Asp Glu 
            900                 905                 910         


Gly Lys Ser Val Ile Ala Arg Gln Gln Glu Arg Arg Glu Ile Leu His 
        915                 920                 925             


Glu Lys Trp Ala Arg Asn Lys Lys Gly Phe Ser Ala Asp Asp Arg Gln 
    930                 935                 940                 


Ala Tyr Glu Glu Ala Leu Ala Ala Val Ile Arg Tyr Arg His Leu Ala 
945                 950                 955                 960 


Ala His Val Thr Leu Thr Asp His Val Arg Leu His Arg Leu Leu Met 
                965                 970                 975     


Ile Val Leu Gly Arg Leu Val Asp Tyr Ser Gly Leu Trp Glu Arg Asp 
            980                 985                 990         


Leu Tyr Phe Val Ala Leu Ala Leu  Ile Tyr Glu Val Gly  Cys Arg Pro 
        995                 1000                 1005             


Glu Asp  Val Phe Glu Lys Glu  Gly Leu Glu Phe Leu  Lys Asn Gly 
    1010                 1015                 1020             


Arg Ile  Val Gly Ala Leu Arg  Lys Leu Lys Gln Thr  Ser Ala Ala 
    1025                 1030                 1035             


His Ala  Val Val Asp Arg Leu  Ser Arg His Phe Gly  Ala Val His 
    1040                 1045                 1050             


Gly Lys  Glu Asn Arg Ala Val  Glu Ile Arg Asn Gly  Phe Ala His 
    1055                 1060                 1065             


Phe Asp  Met Leu Arg Ser Thr  Asn Arg Pro Val Asp  Leu Thr Ala 
    1070                 1075                 1080             


Cys Val  Asn Asp Ala Arg Asn  Leu Met Ala Tyr Asp  Arg Lys Leu 
    1085                 1090                 1095             


Lys Asn  Ala Val Ser Gln Ser  Ile Ala Glu Phe Leu  Ser Arg Glu 
    1100                 1105                 1110             


Gly Leu  Val Ile Ala Trp Ala  Ile Thr Pro Asp His  Arg Leu Gly 
    1115                 1120                 1125             


Thr Ala  Thr Leu Glu Thr Arg  Gln Ala Arg His Leu  Gly Gly Ser 
    1130                 1135                 1140             


Ser Ile  Leu Glu Asp Leu His  Gly Asn Gly Phe Val  Gln Met Val 
    1145                 1150                 1155             


Ala Ala  Leu Phe Asp Arg Cys  Thr Pro Arg Arg Pro  Ser Gly Gly 
    1160                 1165                 1170             


Glu Asn  Gln Arg Gly Gly Lys  Ser Ala Pro Gly Lys  Ser Arg Ala 
    1175                 1180                 1185             


Met Gln  Asn His Glu Ser His  Arg Pro 
    1190                 1195         


<210>  1257
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1257

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Asn Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys His Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Asn Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Ser Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Glu 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Val Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Thr Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Lys Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Glu  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  1258
<211>  1136
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1258

Met Arg Ile Ser Lys Val Lys Val Gln Asp Asn Asn Arg Lys Val Met 
1               5                   10                  15      


Val Leu Met His Arg Thr Thr Val Asn Gly Ala Leu Val Tyr Glu Gly 
            20                  25                  30          


Glu Thr Asn Val Arg Thr Ser Glu Ile Leu Pro Lys Lys Lys Ser Asp 
        35                  40                  45              


Ser Phe Ala Leu Ser Ile Asp Asn Lys Thr Leu Ile Lys Arg Asp Ser 
    50                  55                  60                  


Leu Lys Asp Lys Lys Gln Lys Asp Asn Tyr Asp Ile Val Lys Lys Ile 
65                  70                  75                  80  


Ile Thr Lys Arg Val Leu Pro Ile Gln Ile Ser Asp Glu Asp Val Leu 
                85                  90                  95      


Pro Val Leu Asn His Lys Phe Gln Asn Glu Ile Ile Tyr Tyr Lys Asn 
            100                 105                 110         


Asn Glu Pro Tyr Ser Phe Arg Leu Ala Ser Leu Ile Val Glu Ala Val 
        115                 120                 125             


Lys Glu Arg Asn Pro Glu Lys Leu Gln Pro Tyr Asp Asp Trp Lys Asn 
    130                 135                 140                 


Trp Tyr Ile Ser Thr Lys Ser Ser His Leu Ile Gln Ser Ile Glu Gln 
145                 150                 155                 160 


Asn Lys Ile Asp Leu Asn Gly Thr Asp Ser Lys Arg Lys Thr Ala Leu 
                165                 170                 175     


Gln Ala Trp Ala Thr Lys Tyr Thr Thr Ser Gly Ser Ile Asp Leu Ser 
            180                 185                 190         


Phe Tyr His Lys Leu Tyr Ala Ile Asp Thr Leu Ala Gly Ala Leu His 
        195                 200                 205             


Asn Thr Glu Lys Gly Glu Leu Asp Gln Glu Lys Asn Thr Pro Lys Asn 
    210                 215                 220                 


Ile Asn Leu Phe His Arg Asn Leu Lys Lys Thr Leu Gln Thr His Gln 
225                 230                 235                 240 


Lys Thr Val Phe Gly Thr Arg Glu Ala Pro Asn Val Lys Asn Arg Lys 
                245                 250                 255     


Asp Glu Gln Leu Ala Ile Tyr His Leu Glu Val Val Lys Tyr Leu Glu 
            260                 265                 270         


His Tyr Phe Ser Val Lys Ser Thr Gln Arg Lys Asn Thr Gln Ala Asp 
        275                 280                 285             


Ile Asp Tyr Tyr Leu Lys Ala Glu Thr Ile Lys Ser Thr Ile Thr Asn 
    290                 295                 300                 


Gln Leu Ser Asn Ala Val Arg Asn Tyr Leu Leu Gln Lys Gly Lys Ala 
305                 310                 315                 320 


Glu His His Lys Phe Asp Asn Thr Thr Asp Ser Ser Arg Leu Thr Glu 
                325                 330                 335     


Ile Lys Arg Asn Glu Ala Phe Val Leu Asn Met Ile Asp Ala Cys Ala 
            340                 345                 350         


Phe Ala Ala Asn Asn Ile Arg Asn Ile Val Asp Thr Glu Gln Thr Asn 
        355                 360                 365             


Asp Ile Leu Gly Lys Thr Glu Tyr Val Gln Ser Leu Lys Lys Thr Asn 
    370                 375                 380                 


Arg Val Asn Lys Gln Leu Phe Lys Phe Phe Phe Gly Thr Asp Leu Pro 
385                 390                 395                 400 


Ala Thr Asp Ser His Lys Ala Lys Thr Leu Trp Ala Met Arg Gly Ala 
                405                 410                 415     


Val Gln Gln Ile Arg Asn Val Val Ile His Tyr Lys Gln Gly Ala Leu 
            420                 425                 430         


Asp Thr Ile Phe Lys Ile Glu Lys Phe Glu Tyr Pro Asp Phe Glu Asp 
        435                 440                 445             


Gln Ser Tyr Thr Asp Thr Ile Tyr Lys Thr Cys Leu Glu Thr Glu Leu 
    450                 455                 460                 


Lys Gln Val Pro Glu Ala Phe Ala Gln Gln Leu Lys Thr Gly Gly Val 
465                 470                 475                 480 


Leu Ala Tyr Tyr Pro Tyr Asp Asp Leu Lys Ala Leu Leu Asn Thr Val 
                485                 490                 495     


Ser Phe Ser Leu Cys Arg Thr Val Val Pro Phe Ala Pro Ser Phe Lys 
            500                 505                 510         


Lys Val Gln Lys Gln Gly Gln Asn Tyr Gln Asn Ala Gln Asn Glu Asn 
        515                 520                 525             


Phe Tyr Asp Leu Val Leu Lys Ser Tyr Leu Pro Lys Glu Lys Asp Ala 
    530                 535                 540                 


Ser Lys Glu Glu Ala Tyr Asn Ala Arg Tyr Phe Leu Leu Lys Leu Ile 
545                 550                 555                 560 


Tyr Asn Asn Leu Phe Leu Arg Asn Phe Thr Glu Asn Arg Thr Gln Phe 
                565                 570                 575     


Ser Lys Thr Val Asn Tyr Ile Leu Ser Gln Asn Lys Lys Gln Ala Glu 
            580                 585                 590         


Ala Ser Lys Asn Ser Lys Ala Tyr Ala Phe Glu Ala Val Arg Gln Met 
        595                 600                 605             


Lys Glu Glu Glu Ser Ile Ser Asp Tyr Met Ala Tyr Ile Gln Ser Gln 
    610                 615                 620                 


Leu Met Leu Glu Lys Asn Lys Lys Glu Asp Asp Lys Ser Glu Asp Thr 
625                 630                 635                 640 


His Ile Asn Phe Glu Lys Phe Val Leu Gln Val Phe Ile Lys Gly Phe 
                645                 650                 655     


Asp Asp Phe Leu Gln Asp Glu Lys Phe Lys Phe Ile Ala Lys Pro Tyr 
            660                 665                 670         


Phe Gln Leu Ser Lys Asp Glu Thr Lys Gln Thr Glu Gln Leu Asn Gln 
        675                 680                 685             


Phe Glu Gln Gly Ile Ile Asn Glu Cys Arg Val Gln Ser His Ser Ile 
    690                 695                 700                 


Asn Thr Glu Glu Ala Thr His Val Ala Phe Phe Thr Phe Cys Lys Leu 
705                 710                 715                 720 


Leu Asp Ala Thr His Leu Ser Asn Leu Arg Asn Glu Leu Ile Lys Phe 
                725                 730                 735     


Lys Gln Ser Ala Lys Gln Phe Glu Leu Ser His Met Leu Glu Ile Ile 
            740                 745                 750         


Glu Leu Thr Leu Leu Asn Ala Asp Arg Val Pro Ala Asp Tyr Arg Lys 
        755                 760                 765             


Leu Tyr Glu Asn Lys Thr Asp Cys Leu Asn Arg Ile Leu Phe Phe Ile 
    770                 775                 780                 


Ala Asp Gly Ile Asp Phe Thr Lys Trp Ser Asp Leu Phe Val Gln Thr 
785                 790                 795                 800 


Asp Asn Glu Thr Pro Val Val His Ala Asn Val Glu Leu Thr Val Lys 
                805                 810                 815     


Tyr Gly Thr Ala Lys Leu Leu Glu Gln Leu Ile Ala Lys Asp Val Ser 
            820                 825                 830         


Phe Lys Leu Ser Glu Ser Asn Phe Thr Leu Trp Asp Asn Ala Lys Asp 
        835                 840                 845             


Thr Ile Glu Val Leu Ile Asn Lys Arg Leu Asp Leu His Lys Gln Trp 
    850                 855                 860                 


Glu Glu Ala Val Arg Lys Asp Lys Glu Glu Lys Asn Lys Lys Ile Lys 
865                 870                 875                 880 


Pro Arg Ser Asn Phe Ala Gln Lys Phe Ile Asn Lys Glu Gly Asn Asp 
                885                 890                 895     


Tyr Ser Glu Leu Cys Glu Tyr Ile Asp Asp Tyr Asn Trp Gln Val Asn 
            900                 905                 910         


Lys Leu His Phe Val His Leu Ser Arg Leu His His Leu Thr Ile Asp 
        915                 920                 925             


Ile Leu Gly Arg Met Ala Gly Phe Ile Ala Leu Phe Asp Arg Asp Phe 
    930                 935                 940                 


Gln Leu Phe Asp Ala Ser Arg Thr Gln Asp Pro Tyr Gln Leu Lys Ala 
945                 950                 955                 960 


Phe Val Ser Leu Ser Asn Met Ala Lys Asp Leu Asn Lys Gln Asn Asp 
                965                 970                 975     


Ile Ala Gly Ile Lys Gly Met Glu Tyr Val Val Lys Arg Asp Gly Ser 
            980                 985                 990         


Pro Ile Thr Glu Ala Asp Arg Asn  Ser Leu Lys Asp Cys  Ile Gln Asn 
        995                 1000                 1005             


Lys Arg  Glu Tyr Phe Ser Lys  Val Phe Phe Leu Lys  Gly Ser Lys 
    1010                 1015                 1020             


Gln Phe  Glu Val Arg Asn Tyr  Ile Ala His Phe Asn  Tyr Leu Ser 
    1025                 1030                 1035             


Thr Thr  Ala Glu Asn Tyr Ser  Leu Ile Asp Leu Leu  Asn Glu Ile 
    1040                 1045                 1050             


Arg Asp  Leu Leu Ser Tyr Asp  Arg Lys Leu Lys Asn  Ala Val Asn 
    1055                 1060                 1065             


Lys Ala  Phe Ile Asp Leu Phe  Asp Lys Gln Gly Met  Glu Leu Lys 
    1070                 1075                 1080             


Leu Lys  Leu Asn Ala Asn His  Arg Phe Glu Ile Glu  Ser Val Asn 
    1085                 1090                 1095             


Pro Lys  Leu Ile Tyr His Leu  Gly Thr Thr Leu Lys  Ser Glu Asp 
    1100                 1105                 1110             


Pro Ile  Ser Phe Tyr Gln Val  Lys Leu Glu Tyr Cys  Asn Met Cys 
    1115                 1120                 1125             


Arg Ala  Leu Leu Glu Met Lys  Lys 
    1130                 1135     


<210>  1259
<211>  1197
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1259

Met Gln Ile Ile Lys Pro Tyr Gly Arg Ser His Val Glu Glu Asn Arg 
1               5                   10                  15      


Ala Ala Gly Thr Arg Arg Val Leu Ser Leu Arg Leu Asp Pro Glu Lys 
            20                  25                  30          


Arg Met Asp Ile Val Glu Phe Ala Arg Ser His Glu Lys Leu Val Val 
        35                  40                  45              


Ala Gln Trp Ile Ser Thr Ile Asp Lys Ile Ala Ser Lys Pro Ala Gly 
    50                  55                  60                  


Glu Asn Gly Pro Thr Glu Glu Gln Arg Ala Phe Arg Gln Arg Leu Gly 
65                  70                  75                  80  


Asp Ala Ala Trp Thr Leu Leu Glu Ala Lys Gly Leu Leu Pro Gly Val 
                85                  90                  95      


Lys Gln Pro Glu Val Lys Gln Gln Leu Ala Lys Leu Trp Lys Val Lys 
            100                 105                 110         


Ile Ala Pro Tyr Gly Thr Ala Arg Tyr Arg Ala Glu Lys Asn Arg Lys 
        115                 120                 125             


Pro Pro Ser Val Arg Gly Arg Trp Tyr Asp His Phe Ser Glu Gly Val 
    130                 135                 140                 


Ala Asp Val Ala Asn Val Asp Ala Ala Glu Val Ala Lys Lys Ile His 
145                 150                 155                 160 


Glu His Leu Tyr Ile Ala Gly Tyr Arg Ile Gly Thr Gly Val Arg Asn 
                165                 170                 175     


Arg Arg Gln Gly His Ile Ala Ala Arg Ala Lys Ser Ile Ala Val Asn 
            180                 185                 190         


Val Leu Arg Thr Gly Leu Pro Ala Tyr Gly Gly Gly Val Gly Ala Gly 
        195                 200                 205             


Trp Met Ala Glu Asp Arg Asp Ser Tyr Ala Lys Ala Gly Asn Phe Val 
    210                 215                 220                 


Gln Glu Ile Arg Leu Ala Ala Glu Arg Arg Glu Arg Gly Glu Asp Lys 
225                 230                 235                 240 


Ala Gly Thr Leu Arg Val Thr Ser Ser Ile Ala Gly Lys Ala Leu Phe 
                245                 250                 255     


Glu His Tyr Ala Arg Leu Phe Lys Arg Ala Asp Gly Lys Ala Leu Ser 
            260                 265                 270         


Ile Arg Glu Ala Arg Glu Arg Thr Pro Gly Leu Phe Asn Leu His Met 
        275                 280                 285             


Ala Val Lys Asp Cys Tyr Ser Arg Ile Leu Lys Asn His Lys Lys Asp 
    290                 295                 300                 


Leu Lys Ala His Gly Asp Arg Arg Arg Lys Val Ser Ala Leu Leu Pro 
305                 310                 315                 320 


Ser Thr Met Asp Gly Leu Phe Ala Leu Leu Asp Ala Lys Arg Thr Asn 
                325                 330                 335     


Arg Asp Leu Asn Thr Leu Val Arg Leu Gly Lys Val Ile His Tyr Lys 
            340                 345                 350         


Ser Ser Gly Gly Val Glu Asp Trp Pro Ser Asp Pro Val His Asn Trp 
        355                 360                 365             


Pro Ala Asp Val Thr Arg Ser Phe Phe Trp Thr Ser Asp Gly Gln Ala 
    370                 375                 380                 


Ile Met Lys Arg Asn Glu Ala Phe Val Arg Val Trp Arg His Val Leu 
385                 390                 395                 400 


Ala Leu Ala Ser Arg Thr Leu Thr Asp Trp Ala Asp Pro Asp Gly Lys 
                405                 410                 415     


Ile Arg Ser Asp Ile Leu Leu Ser Gly Pro Ile Glu Arg Ala Thr Gly 
            420                 425                 430         


Asp Cys Phe Asp Asn Gly Asn Tyr Ala Arg Lys Leu Ala Leu Leu Phe 
        435                 440                 445             


Gly Ser Arg Ala Asp Ile Phe Gln Cys Ala Gly Asp Asp Ala Val Gln 
    450                 455                 460                 


Lys Asn Val Leu Arg His Ala Leu Glu Gly Ile Ala Gly Leu Arg His 
465                 470                 475                 480 


Ser Ser Phe His Phe Lys Gly Leu Gly Gly Phe Ala Asp Ala Leu Thr 
                485                 490                 495     


Arg Ser Gln Phe Ala Leu Asp Glu Asn Val Ile Gly Ala Val Arg Gln 
            500                 505                 510         


Leu Trp Gln Ala Asp Val Gly Gly Arg Ala Gly Gln Leu Leu Lys Thr 
        515                 520                 525             


Met Arg Ala Ala His Phe Glu Tyr Phe Leu Gly Glu Ser Gln Asn Arg 
    530                 535                 540                 


Lys Leu Leu Ala Val Leu Ser Asn Ala Glu Ser Ala Leu Ile Pro Leu 
545                 550                 555                 560 


Pro Arg Phe Ser Lys Met Leu Glu Arg Ala Gln Asn Ala Trp Arg Asp 
                565                 570                 575     


Gly Lys Asp Gly Leu Arg Leu Pro Lys Pro Ala Asn Arg Thr Asp Arg 
            580                 585                 590         


Glu Asn Pro Ala Arg Leu Cys Gln Tyr Ala Ala Leu Lys Leu Leu Tyr 
        595                 600                 605             


Glu Arg Ala Phe Arg Asn Trp Leu Tyr Glu Arg Ser Ala Glu Ser Leu 
    610                 615                 620                 


Asn Arg Phe Ile Asp Arg Ala Val Glu Arg Ala Thr Ala Ala Ala Arg 
625                 630                 635                 640 


Asp Leu Asn Ala Arg Asp Asp Glu Asp Arg Arg Asp Ile Ile Val Ala 
                645                 650                 655     


Lys Ala Ala Thr Leu Gly Arg Leu Ala Asp Gly Glu Thr Val Glu Thr 
            660                 665                 670         


Phe Phe Phe Lys Leu Ser Ala Gln Thr Ala Ser Glu Met Arg Val Gln 
        675                 680                 685             


Arg Gly Tyr Asp Ser Asp Ala Asp Arg Ala Arg Glu Gln Ala Gly Tyr 
    690                 695                 700                 


Ile Glu Asn Leu Lys Ser Asp Val Val Val Leu Ala Phe Gly Ala Tyr 
705                 710                 715                 720 


Leu Lys Glu Ala Ser Phe Asp Phe Leu Leu Lys Leu Ser Pro Asp Ala 
                725                 730                 735     


Pro Lys Pro Glu Lys Pro Leu Cys Ile Leu Asp Gly Met Arg Arg Asp 
            740                 745                 750         


Glu Gly Asp Arg Pro Ala Glu Asn Trp Gln Met Thr Leu Tyr Phe Leu 
        755                 760                 765             


Ile His Leu Val Pro Val Asp Glu Ile Gly Lys Leu Leu His Gln Met 
    770                 775                 780                 


Arg Lys Trp Glu Ser Leu Ala Ala Lys Pro Val Met Ala Asp Pro Asp 
785                 790                 795                 800 


Arg Arg Gln Leu Asp Lys Ser Thr Ile Ala Asp Asn Val Arg Lys Val 
                805                 810                 815     


Gln Ser Val Leu Glu Leu Tyr Leu Asp Met His Asp Ala Lys Phe Asp 
            820                 825                 830         


Gly Glu Ala Ala Leu Ile Gly Thr Gly Ala Phe Lys Lys Leu Tyr Glu 
        835                 840                 845             


Pro Glu Asp Leu Phe Asp Arg Ile Phe Pro Arg Gln Phe Gly Ala Asp 
    850                 855                 860                 


Asp Asp Arg Arg Ile Pro Arg Arg Gly Leu Arg Glu Ile Met Arg Phe 
865                 870                 875                 880 


Gly His Leu Gln Val Leu Arg Pro Val Phe Gln Lys His Pro Ile Gln 
                885                 890                 895     


Leu Ala Lys Val Glu Lys Phe Phe Ala Ala Glu Glu Arg Gln Asp Glu 
            900                 905                 910         


Gly Lys Ser Val Ile Ala Arg Gln Gln Glu Arg Arg Glu Ile Leu His 
        915                 920                 925             


Glu Lys Trp Ala Arg Asn Lys Lys Gly Phe Ser Ala Asp Asp Arg Gln 
    930                 935                 940                 


Ala Tyr Glu Glu Ala Leu Ala Ala Val Ile Arg Tyr Arg His Leu Ala 
945                 950                 955                 960 


Ala His Val Thr Leu Thr Asp His Val Arg Leu His Arg Leu Leu Met 
                965                 970                 975     


Ile Val Leu Gly Arg Leu Val Asp Tyr Ser Gly Leu Trp Glu Arg Asp 
            980                 985                 990         


Leu Tyr Phe Val Ala Leu Ala Leu  Ile Tyr Glu Val Gly  Cys Arg Pro 
        995                 1000                 1005             


Glu Asp  Val Phe Glu Lys Glu  Gly Leu Glu Phe Leu  Lys Asn Gly 
    1010                 1015                 1020             


Arg Ile  Val Gly Ala Leu Arg  Lys Leu Lys Gln Thr  Ser Ala Ala 
    1025                 1030                 1035             


His Ala  Val Val Asp Arg Leu  Ser Arg His Phe Gly  Ala Val His 
    1040                 1045                 1050             


Gly Lys  Glu Asn Arg Ala Val  Glu Ile Arg Asn Gly  Phe Ala His 
    1055                 1060                 1065             


Phe Asp  Met Leu Arg Ser Thr  Asn Arg Pro Val Asp  Leu Thr Ala 
    1070                 1075                 1080             


Cys Val  Asn Asp Ala Arg Asn  Leu Met Ala Tyr Asp  Arg Lys Leu 
    1085                 1090                 1095             


Lys Asn  Ala Val Ser Gln Ser  Ile Ala Glu Phe Leu  Ser Arg Glu 
    1100                 1105                 1110             


Gly Leu  Val Ile Ala Trp Ala  Ile Thr Pro Asp His  Arg Leu Gly 
    1115                 1120                 1125             


Thr Ala  Thr Leu Glu Thr Arg  Gln Ala Arg His Leu  Gly Gly Ser 
    1130                 1135                 1140             


Ser Ile  Leu Glu Asp Leu His  Gly Asn Gly Phe Val  Gln Met Val 
    1145                 1150                 1155             


Ala Ala  Leu Phe Asp Arg Cys  Thr Pro Arg Arg Pro  Ser Gly Gly 
    1160                 1165                 1170             


Glu Asn  Gln Arg Gly Gly Lys  Ser Ala Pro Gly Lys  Ser Arg Ala 
    1175                 1180                 1185             


Met Gln  Asn His Glu Ser His  Arg Pro 
    1190                 1195         


<210>  1260
<211>  1184
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1260

Met Arg Val Ser Lys Val Lys Val Leu Gly Asn Glu Glu Thr Lys Gly 
1               5                   10                  15      


Arg Ile Val Leu Met His Arg Ser Pro Val Lys Gly Gln Leu Ile Tyr 
            20                  25                  30          


Ser Glu Asp Ala Gly Lys Arg Asp Arg Thr Glu Asp Ile Ile Pro Glu 
        35                  40                  45              


Gln Lys Leu Glu Ser Phe His Leu Ser Ile Leu Asn Lys Thr Phe Leu 
    50                  55                  60                  


Arg Lys Glu Phe Phe Lys Lys Glu Leu Lys His Glu Ala Lys Lys Asn 
65                  70                  75                  80  


Gly Leu Lys Gly Asp Ala Glu Asp Lys Tyr Ile Ser Glu Lys Leu Lys 
                85                  90                  95      


Glu Tyr His Ser Leu Leu Gln Phe Ile Asp Asp Val Leu Ser Val Lys 
            100                 105                 110         


Tyr Asn Glu Asn Arg Lys Ala Ile Lys Phe Pro Glu Tyr Leu Thr Arg 
        115                 120                 125             


Glu Met Ile Glu Ile Phe Leu Asn His Lys Phe Arg Lys Glu Val Thr 
    130                 135                 140                 


Tyr Thr Asn Lys Asn Gly Ala Ser Val Ser Phe Leu Leu Ser Thr Leu 
145                 150                 155                 160 


Ile Leu Asn Ala Ile Glu Lys His Ser Val Ile Glu Met Gln Pro Phe 
                165                 170                 175     


Val Asp Trp Arg Asn Trp Phe Val Glu Thr Lys Ser Lys Phe Leu Lys 
            180                 185                 190         


Lys Ser Ile Ile Asn Asn Cys Ile Pro Thr Asn Gly Gly Pro Ile Ser 
        195                 200                 205             


Arg Arg Arg Glu Thr Leu Met Lys Trp Arg Asp Asp Tyr Phe Thr Asn 
    210                 215                 220                 


Ala Glu Ile Asp Leu Ala Arg Leu His Lys Lys Phe Gly Thr Asp Thr 
225                 230                 235                 240 


Leu Met Ala Ser Leu Arg Glu Val Pro Gln Thr Glu Lys Ser Gly Asn 
                245                 250                 255     


Glu Tyr His Arg Leu Leu Lys Ser Cys Leu Gln Ser His Gln Lys Lys 
            260                 265                 270         


Leu Phe Gly Lys Arg Ala Glu Gly Tyr Asp Ile Asn Arg Ala Asp Asn 
        275                 280                 285             


Gln Leu Tyr Val Tyr Asn Thr Glu Val Val Lys Tyr Met Glu His Tyr 
    290                 295                 300                 


Phe Pro Val Lys Ser Ser Lys Arg Arg Asn Ser Thr Ala Glu Ile Lys 
305                 310                 315                 320 


Tyr Tyr Leu Gln Thr Asp Thr Ile Lys Cys Cys Leu His His Gln Ile 
                325                 330                 335     


Ile Asn Ala Val Arg Gly Leu Ala Leu Arg Glu Gly Lys Phe Asn Leu 
            340                 345                 350         


His Gly Phe Asp Asp Lys Leu Ile Pro Asn Glu Arg Asn Val Ser Ser 
        355                 360                 365             


Ser Ile Leu Asn Glu Leu Lys Thr Ser Glu Gly Phe Val Leu Asn Met 
    370                 375                 380                 


Leu Gly Gly Cys Ala Phe Ala Ala Asn Cys Leu Arg Asn Ile Val Asp 
385                 390                 395                 400 


Ala Thr Gln Arg Ser Asp Leu Leu Gly Phe Arg Cys Phe Glu Val Ser 
                405                 410                 415     


Leu Lys Lys Gly Lys Ser Asn Ser Asp Leu Phe Ala Leu Phe Phe Gly 
            420                 425                 430         


Phe Gly Arg Glu Asp Met Asp Asp Asp Ser Glu Trp Glu Lys His Leu 
        435                 440                 445             


Tyr Ala Ala Arg Tyr Ser Val Ser Glu Ile Arg Asn Arg Val Ala His 
    450                 455                 460                 


Tyr His Lys Ser Ala Ile Glu Asn Ile Tyr Asn Ile Thr Asp Phe Glu 
465                 470                 475                 480 


Tyr Arg Glu Asn Ser Met Cys Ser Tyr Thr Asp Thr Lys Phe Thr Thr 
                485                 490                 495     


Ala Leu Gln Asn Glu Ile Tyr Asn Thr Pro Lys Ala Phe Ser Leu Gln 
            500                 505                 510         


Leu Met Thr Gly Lys Val Leu Glu Tyr Tyr Pro Lys Glu Lys Leu Val 
        515                 520                 525             


Ser Phe Phe Gln Lys Tyr Lys Phe Ser Leu Tyr Arg Ser Val Val Pro 
    530                 535                 540                 


Phe Ala Pro Gly Phe Lys Asn Ile Met Arg Thr Gly Val Asn Tyr Gln 
545                 550                 555                 560 


Asn Ala Thr Gln Asn Arg Leu Phe Tyr Asp Met Gly Leu Thr Ala Phe 
                565                 570                 575     


Gln Asp Lys Asp Arg Tyr Ile Asp Asp Val Glu Ala Trp Asn Ala Arg 
            580                 585                 590         


Tyr Phe Phe Met Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Arg Phe 
        595                 600                 605             


Thr Asn Asp Lys Asn Asp Leu Phe Arg Lys Thr Val Glu Gln Val Leu 
    610                 615                 620                 


Glu Val Asn Arg Ser His Met Glu Lys Val Gly Lys Asp Asp Arg Gln 
625                 630                 635                 640 


Ala Phe Gly Glu Val Arg Gln Met Arg Glu Asn Glu Thr Ala Asn Asp 
                645                 650                 655     


Tyr Met Ala Tyr Leu Gln Ser Ser Leu Arg Met Glu Lys Asn Lys Lys 
            660                 665                 670         


Glu Leu Glu Gly Asn Gly Ala Lys Arg Ile Asn Phe Glu Lys Phe Ile 
        675                 680                 685             


Leu Gln Met Phe Val Lys Gly Phe Asp Ser Phe Leu Lys Asp Gly Ala 
    690                 695                 700                 


Phe Glu Phe Val His Ser Pro Glu Asn Cys Leu Thr Gly Ser Thr Glu 
705                 710                 715                 720 


Lys Glu Arg Ala Lys Glu Arg Asn Ser Leu Cys Glu Glu Ile Gly Asn 
                725                 730                 735     


Tyr Val Arg Leu Val Ser Thr Val Ile Asp Pro Gly Lys Gly Ser His 
            740                 745                 750         


Val Ala Phe Tyr Val Phe Cys Lys Met Leu Asn Ser Val Tyr Leu Ser 
        755                 760                 765             


Asn Ile Arg Asn Glu Met Ile Lys Tyr His Lys Val Val Arg Thr Asp 
    770                 775                 780                 


Glu Leu Ala His Leu Ile Glu Ile Ile Glu Leu Cys Leu Leu Ser Ala 
785                 790                 795                 800 


Asp Ala Val Ser Gln Lys Thr Val Asn Ala Asp Lys Leu Ser His Phe 
                805                 810                 815     


Phe Ala Glu Gly Val Asn Val Asp Asp Asp Glu Asn Val Ile His Ala 
            820                 825                 830         


Ser Met Glu Thr Phe Arg Lys Tyr Gly Thr Arg Asp Leu Phe His Lys 
        835                 840                 845             


Leu Met Leu Gln Asp Asp Arg Phe Leu Val Ser Ser Asp Asp Tyr Arg 
    850                 855                 860                 


Glu Trp Glu Glu Met Lys Glu Lys Ile Glu Gly Lys Val Lys Gln Arg 
865                 870                 875                 880 


Glu Leu Leu His Ala Glu Trp Cys Glu Ala Lys Glu Lys Asp Lys Lys 
                885                 890                 895     


Ser Arg Lys Val Lys Ser Asn Ser Arg Thr Cys Phe Glu Lys Lys Phe 
            900                 905                 910         


Met Gly Ala Lys Ala Glu Glu Tyr Tyr Ser Leu Cys Asn Val Ile Asp 
        915                 920                 925             


Lys Tyr Asn Trp Leu Asp Asn Lys Leu His Leu Val His Leu Asn Lys 
    930                 935                 940                 


Leu His Asn Leu Val Ile Glu Ile Leu Gly Arg Met Val Gly Phe Thr 
945                 950                 955                 960 


Ala Leu Phe Glu Arg Asp Phe Gln Tyr Ile Cys Lys Ser Asp Ser Glu 
                965                 970                 975     


Tyr Glu Gln Leu Tyr Asn Leu Asp Phe Asn Met Gly Leu Pro Lys Phe 
            980                 985                 990         


Lys Asn Ser Ile Lys Gly Ser Gly  Lys Ala Lys Asn Ser  Thr Gln Asn 
        995                 1000                 1005             


Ile Asp  His Asn Ala Thr Gly  Ile Gly Asn Ser Ser  Asn Leu Leu 
    1010                 1015                 1020             


Lys Glu  Asn Ser Asn Gly Thr  His Tyr Cys Lys Asn  Leu Ser Gly 
    1025                 1030                 1035             


Asp Gly  Val Glu Asp Lys Leu  Lys Arg Leu Phe Leu  Tyr Asp Asp 
    1040                 1045                 1050             


Tyr Arg  Asn Val Arg Asn Phe  Val Ala His Phe Asn  Tyr Leu Thr 
    1055                 1060                 1065             


Arg Val  Glu Asp Asp Leu Gly  Gly Asn Asp Ala Val  Lys Leu Ser 
    1070                 1075                 1080             


Gly Thr  Arg Tyr Ser Leu Ile  Glu Leu Ile Asn Glu  Leu Arg Asn 
    1085                 1090                 1095             


Leu Leu  Lys Tyr Asp Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ser 
    1100                 1105                 1110             


Phe Ile  Asp Met Phe Glu Arg  His Gly Met His Val  Lys Met Lys 
    1115                 1120                 1125             


Leu Asn  His Asn His Lys Leu  Phe Val Asp Ser Ile  Ser Pro Arg 
    1130                 1135                 1140             


Lys Ile  Lys His Leu Gly Gly  Gly Tyr Lys Lys Arg  Gly Lys Asp 
    1145                 1150                 1155             


Asp Lys  Met Tyr Val Gln Thr  Thr Asn His Val Asp  Pro Leu Tyr 
    1160                 1165                 1170             


Cys Asp  Met Cys Arg Ala Leu  Leu Glu Met Lys 
    1175                 1180                 


<210>  1261
<211>  1184
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1261

Met Arg Val Ser Lys Val Lys Val Leu Gly Asn Glu Glu Thr Lys Gly 
1               5                   10                  15      


Arg Ile Val Leu Met His Arg Ser Pro Val Lys Gly Gln Leu Ile Tyr 
            20                  25                  30          


Ser Glu Asp Ala Gly Lys Arg Asp Arg Thr Glu Asp Ile Ile Pro Glu 
        35                  40                  45              


Gln Lys Leu Glu Ser Phe His Leu Ser Ile Leu Asn Lys Thr Phe Leu 
    50                  55                  60                  


Arg Lys Glu Phe Phe Lys Lys Glu Leu Lys His Glu Ala Lys Lys Asn 
65                  70                  75                  80  


Gly Leu Lys Gly Asp Ala Glu Asp Lys Tyr Ile Ser Glu Lys Leu Lys 
                85                  90                  95      


Glu Tyr His Ser Leu Leu Gln Phe Ile Asp Asp Val Leu Ser Val Lys 
            100                 105                 110         


Tyr Asn Glu Asn Arg Lys Ala Ile Lys Phe Pro Glu Tyr Leu Thr Arg 
        115                 120                 125             


Glu Met Ile Glu Ile Phe Leu Asn His Lys Phe Arg Lys Glu Val Thr 
    130                 135                 140                 


Tyr Thr Asn Lys Asn Gly Ala Ser Val Ser Phe Leu Leu Ser Thr Leu 
145                 150                 155                 160 


Ile Leu Asn Ala Ile Glu Lys His Ser Val Ile Glu Met Gln Pro Phe 
                165                 170                 175     


Val Asp Trp Arg Asn Trp Phe Val Glu Thr Lys Ser Lys Phe Leu Lys 
            180                 185                 190         


Lys Ser Ile Ile Asn Asn Cys Ile Pro Thr Asn Gly Gly Pro Ile Ser 
        195                 200                 205             


Arg Arg Arg Glu Thr Leu Met Lys Trp Arg Asp Asp Tyr Phe Thr Asn 
    210                 215                 220                 


Ala Glu Ile Asp Leu Ala Arg Leu His Lys Lys Phe Gly Thr Asp Thr 
225                 230                 235                 240 


Leu Met Ala Ser Leu Arg Glu Val Pro Gln Thr Glu Lys Ser Gly Asn 
                245                 250                 255     


Glu Tyr His Arg Leu Leu Lys Ser Cys Leu Gln Ser His Gln Lys Lys 
            260                 265                 270         


Leu Phe Gly Lys Arg Ala Glu Gly Tyr Asp Ile Asn Arg Ala Asp Asn 
        275                 280                 285             


Gln Leu Tyr Val Tyr Asn Thr Glu Val Val Lys Tyr Met Glu His Tyr 
    290                 295                 300                 


Phe Pro Val Lys Ser Ser Lys Arg Arg Asn Ser Thr Ala Glu Ile Lys 
305                 310                 315                 320 


Tyr Tyr Leu Gln Thr Asp Thr Ile Lys Cys Cys Leu His His Gln Ile 
                325                 330                 335     


Ile Asn Ala Val Arg Gly Leu Ala Leu Arg Glu Gly Lys Phe Asn Leu 
            340                 345                 350         


His Gly Phe Asp Asp Lys Leu Ile Pro Asn Glu Arg Asn Val Ser Ser 
        355                 360                 365             


Ser Ile Leu Asn Glu Leu Lys Thr Ser Glu Gly Phe Val Leu Asn Met 
    370                 375                 380                 


Leu Gly Gly Cys Ala Phe Ala Ala Asn Cys Leu Arg Asn Ile Val Asp 
385                 390                 395                 400 


Ala Thr Gln Arg Ser Asp Leu Leu Gly Phe Arg Cys Phe Glu Val Ser 
                405                 410                 415     


Leu Lys Lys Gly Lys Ser Asn Ser Asp Leu Phe Ala Leu Phe Phe Gly 
            420                 425                 430         


Phe Gly Arg Glu Asp Met Asp Asp Asp Ser Glu Trp Glu Lys His Leu 
        435                 440                 445             


Tyr Ala Ala Arg Tyr Ser Val Ser Glu Ile Arg Asn Arg Val Ala His 
    450                 455                 460                 


Tyr His Lys Ser Ala Ile Glu Asn Ile Tyr Asn Ile Thr Asp Phe Glu 
465                 470                 475                 480 


Tyr Arg Glu Asn Ser Met Cys Ser Tyr Thr Asp Thr Lys Phe Thr Thr 
                485                 490                 495     


Ala Leu Gln Asn Glu Ile Tyr Asn Thr Pro Lys Ala Phe Ser Leu Gln 
            500                 505                 510         


Leu Met Thr Gly Lys Val Leu Glu Tyr Tyr Pro Lys Glu Lys Leu Val 
        515                 520                 525             


Ser Phe Phe Gln Lys Tyr Lys Phe Ser Leu Tyr Arg Ser Val Val Pro 
    530                 535                 540                 


Phe Ala Pro Gly Phe Lys Asn Ile Met Arg Thr Gly Val Asn Tyr Gln 
545                 550                 555                 560 


Asn Ala Thr Gln Asn Arg Leu Phe Tyr Asp Met Gly Leu Thr Ala Phe 
                565                 570                 575     


Gln Asp Lys Asp Arg Tyr Ile Asp Asp Val Glu Ala Trp Asn Ala Arg 
            580                 585                 590         


Tyr Phe Phe Met Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Arg Phe 
        595                 600                 605             


Thr Asn Asp Lys Asn Asp Leu Phe Arg Lys Thr Val Glu Gln Val Leu 
    610                 615                 620                 


Glu Val Asn Arg Ser His Met Glu Lys Val Gly Lys Asp Asp Arg Gln 
625                 630                 635                 640 


Ala Phe Gly Glu Val Arg Gln Met Arg Glu Asn Glu Thr Ala Asn Asp 
                645                 650                 655     


Tyr Met Ala Tyr Leu Gln Ser Ser Leu Arg Met Glu Lys Asn Lys Lys 
            660                 665                 670         


Glu Leu Glu Gly Asn Gly Ala Lys Arg Ile Asn Phe Glu Lys Phe Ile 
        675                 680                 685             


Leu Gln Met Phe Val Lys Gly Phe Asp Ser Phe Leu Lys Asp Gly Ala 
    690                 695                 700                 


Phe Glu Phe Val His Ser Pro Glu Asn Cys Leu Thr Gly Ser Thr Glu 
705                 710                 715                 720 


Lys Glu Arg Ala Lys Glu Arg Asn Ser Leu Cys Glu Glu Ile Gly Asn 
                725                 730                 735     


Tyr Val Arg Leu Val Ser Thr Val Ile Asp Pro Gly Lys Gly Ser His 
            740                 745                 750         


Val Ala Phe Tyr Val Phe Cys Lys Met Leu Asn Ser Val Tyr Leu Ser 
        755                 760                 765             


Asn Ile Arg Asn Glu Met Ile Lys Tyr His Lys Val Val Arg Thr Asp 
    770                 775                 780                 


Glu Leu Ala His Leu Ile Glu Ile Ile Glu Leu Cys Leu Leu Ser Ala 
785                 790                 795                 800 


Asp Ala Val Ser Gln Lys Thr Val Asn Ala Asp Lys Leu Ser His Phe 
                805                 810                 815     


Phe Ala Glu Gly Val Asn Val Asp Asp Asp Glu Asn Val Ile His Ala 
            820                 825                 830         


Ser Met Glu Thr Phe Arg Lys Tyr Gly Thr Arg Asp Leu Phe His Lys 
        835                 840                 845             


Leu Met Leu Gln Asp Asp Arg Phe Leu Val Ser Ser Asp Asp Tyr Arg 
    850                 855                 860                 


Glu Trp Glu Glu Met Lys Glu Lys Ile Glu Gly Lys Val Lys Gln Arg 
865                 870                 875                 880 


Glu Leu Leu His Ala Glu Trp Cys Glu Ala Lys Glu Lys Asp Lys Lys 
                885                 890                 895     


Ser Arg Lys Val Lys Ser Asn Ser Arg Thr Cys Phe Glu Lys Lys Phe 
            900                 905                 910         


Met Gly Ala Lys Ala Glu Glu Tyr Tyr Ser Leu Cys Asn Val Ile Asp 
        915                 920                 925             


Lys Tyr Asn Trp Leu Asp Asn Lys Leu His Leu Val His Leu Asn Lys 
    930                 935                 940                 


Leu His Asn Leu Val Ile Glu Ile Leu Gly Arg Met Val Gly Phe Thr 
945                 950                 955                 960 


Ala Leu Phe Glu Arg Asp Phe Gln Tyr Ile Cys Lys Ser Asp Ser Glu 
                965                 970                 975     


Tyr Glu Gln Leu Tyr Asn Leu Asp Phe Asn Met Gly Leu Pro Lys Phe 
            980                 985                 990         


Lys Asn Ser Ile Lys Gly Ser Gly  Lys Ala Lys Asn Ser  Thr Gln Asn 
        995                 1000                 1005             


Ile Asp  His Asn Ala Thr Gly  Ile Gly Asn Ser Ser  Asn Leu Leu 
    1010                 1015                 1020             


Lys Glu  Asn Ser Asn Gly Thr  His Tyr Cys Lys Asn  Leu Ser Gly 
    1025                 1030                 1035             


Asp Gly  Val Glu Asp Lys Leu  Lys Arg Leu Phe Leu  Tyr Asp Asp 
    1040                 1045                 1050             


Tyr Arg  Asn Val Arg Asn Phe  Val Ala His Phe Asn  Tyr Leu Thr 
    1055                 1060                 1065             


Arg Val  Glu Asp Asp Leu Gly  Gly Asn Asp Ala Val  Lys Leu Ser 
    1070                 1075                 1080             


Gly Thr  Arg Tyr Ser Leu Ile  Glu Leu Ile Asn Glu  Leu Arg Asn 
    1085                 1090                 1095             


Leu Leu  Lys Tyr Asp Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ser 
    1100                 1105                 1110             


Phe Ile  Asp Met Phe Glu Arg  His Gly Met His Val  Lys Met Lys 
    1115                 1120                 1125             


Leu Asn  His Asn His Lys Leu  Phe Val Asp Ser Ile  Ser Pro Arg 
    1130                 1135                 1140             


Lys Ile  Lys His Leu Gly Gly  Gly Tyr Lys Lys Arg  Gly Lys Asp 
    1145                 1150                 1155             


Asp Lys  Met Tyr Val Gln Thr  Thr Asn His Val Asp  Pro Leu Tyr 
    1160                 1165                 1170             


Cys Asp  Met Cys Arg Ala Leu  Leu Glu Met Lys 
    1175                 1180                 


<210>  1262
<211>  1048
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1262

Met Arg Val Phe Ile Val Lys Ile Thr Lys Asn Ala Lys Asn Gly Lys 
1               5                   10                  15      


Val Gln Phe Tyr Arg Asn Met Glu Gln Gly Gly Leu Arg Asp Asn Lys 
            20                  25                  30          


Ile Arg Asn Ser Asp Asp Ile Thr Glu Ser Ala Ile Glu Gln Leu Asp 
        35                  40                  45              


Leu Lys Lys Ser Tyr Thr Gly Arg Ile Leu Ser Ala Asp Ala Gln Arg 
    50                  55                  60                  


Gly Lys Glu Asn Pro Phe Tyr Ser Phe Val Arg Ser Leu Thr Gly Glu 
65                  70                  75                  80  


Leu Asp Asp Arg Ile Pro Ile Asp Tyr Leu Arg Asp Val Lys Phe Lys 
                85                  90                  95      


Glu Ala Asp Arg Lys Cys Asp Ile Gln Cys Ser Ile Ser Lys Tyr Leu 
            100                 105                 110         


Ser His Tyr Val Lys Lys Leu Thr Cys Asp Asp Gly Ser Thr Thr Leu 
        115                 120                 125             


Glu Ser Leu Leu Leu Asp Tyr Tyr Lys Lys Ser Leu Thr Asp Glu Glu 
    130                 135                 140                 


Thr Glu Thr Lys Leu Glu Gln Ile Gln Asp Asp Ile Ser Asn Arg Leu 
145                 150                 155                 160 


Ser His Lys Lys Glu Asn Phe Lys Ile Ser Phe Gln Asn Asn Ser Ile 
                165                 170                 175     


Pro Phe Glu Lys Tyr Ala Val Thr Ala Gly Asp Thr Val Lys Phe Lys 
            180                 185                 190         


Ile His Pro Ser Ser Asn Lys Met Lys Trp Phe Phe Gly Phe Leu Gly 
        195                 200                 205             


Glu Gln Gly Val Asn Lys Glu Arg Phe Asn Asp Tyr Met Glu Met Tyr 
    210                 215                 220                 


Arg Tyr Thr Asn Leu Glu Ser Glu Leu Asn Ser Phe Thr Asp Glu His 
225                 230                 235                 240 


Phe Ser Asn Ser Asp Asn Ile Asn Gly Asp Tyr Ile Ala Lys Lys Ile 
                245                 250                 255     


Tyr Glu Ile Met Lys Glu Tyr Asn Ser Ser Leu Tyr Asn Thr Glu Lys 
            260                 265                 270         


Asn Gly Arg Ile Ser Glu Ile Gln Leu Gln Gly Tyr Ser Phe Phe Leu 
        275                 280                 285             


Asn Glu Ile Arg Asp His Phe Lys Lys Tyr Phe Pro Pro Lys Ser Asn 
    290                 295                 300                 


Lys Ser Gln Gly Arg Ser Gly Asn Lys Gly Pro Arg Ile Lys Ser Leu 
305                 310                 315                 320 


Thr Asn Ser Lys Asn Val Lys Tyr Phe Tyr Ser Lys Asp Phe Val Tyr 
                325                 330                 335     


Gln Gln Val Trp Lys His Ile Val Asn Gln Leu Val Ser Gly Leu Ile 
            340                 345                 350         


Gln Tyr Gly Lys Leu Tyr Thr Tyr Cys Val Ala Pro Gly Ser Asp Tyr 
        355                 360                 365             


His Glu Ile Asn Ser Asp Ile Met Gln Asp Ile Gln Ile Gln Glu Ala 
    370                 375                 380                 


Ile Lys Lys Gln Leu Leu Leu Ser Val Val Trp Ser Val Asp Arg Leu 
385                 390                 395                 400 


Asn Tyr Tyr Ser Asn Tyr Ala Gly Asp Lys Ile Glu Arg Met Tyr Lys 
                405                 410                 415     


Glu Asp Ser Asn Asp Ile Leu Gly Glu Leu His Lys Ser Thr Tyr Phe 
            420                 425                 430         


Gly Gly Arg Gly Asn Ser Arg Phe Ala Ser Asp Phe Ala Gln Gly Ile 
        435                 440                 445             


Ile Ser Asp Pro Glu Lys Cys Asn Lys Leu Phe Lys Lys Leu Ser Asn 
    450                 455                 460                 


Thr Phe Leu Leu Lys Gln Glu Glu Asn Asn Ser Glu Phe Leu Ile Gly 
465                 470                 475                 480 


Leu Ile His Glu Ile Val Asp Asn Leu Tyr Glu Val Arg Leu Lys Val 
                485                 490                 495     


Met His Tyr Gln Lys Gly Ala Leu Lys Phe Asn Asp Val Thr Gly Thr 
            500                 505                 510         


Val Leu Leu Glu Thr Gln Leu Arg Arg Asp Ile Asn Asn Val Gln Asn 
        515                 520                 525             


Cys Phe Gln Glu Gln Ile Arg Ser Met Asn Ile Ser Arg Tyr Tyr Ser 
    530                 535                 540                 


Pro Glu Leu Ile Asn Lys Leu Phe Thr Arg Cys Gly Leu Lys Phe Lys 
545                 550                 555                 560 


Leu Tyr Ala Ser Thr Pro Ser Met Ile Pro Ser Phe Lys Lys Val Tyr 
                565                 570                 575     


Ala Lys Gly Val Asn Leu Phe Lys Gly Asp Ser Asp Lys Glu Leu Lys 
            580                 585                 590         


Trp Tyr Leu Asp Asp Lys Gly Asn Met Gln Ser Glu Glu Ala Val Ser 
        595                 600                 605             


Val Tyr Arg Asn Leu Leu Gln Leu Ile Tyr Tyr His Val Tyr Ile Pro 
    610                 615                 620                 


Ser Ile Gly Glu Asp Asp Arg Asp Asn Leu Val Ile Pro Phe Ile Ala 
625                 630                 635                 640 


Arg Thr Ile Lys Trp Asn Lys Glu Lys Ser Tyr Glu Lys Arg Lys Asn 
                645                 650                 655     


Ser Lys Lys Asn Ser Tyr Lys Asn Lys Gly Lys Lys Ala Tyr Ile Asn 
            660                 665                 670         


Val Asn Ala Tyr Arg Tyr Glu Ser Met Pro Lys Tyr Gln Pro Gly Gln 
        675                 680                 685             


Ser Leu Ser Glu Tyr Met Ser Val Leu Gln Arg Ala Gln Ser Asp Lys 
    690                 695                 700                 


Glu Thr Thr Asn Ile Ala Thr Gly Glu Ser Gly Asp Glu Arg Lys Asn 
705                 710                 715                 720 


His Phe Thr Asn Phe Val Gln Asp Ile Phe Val Phe Ser Phe Ala Ser 
                725                 730                 735     


Phe Leu Ser Cys Lys Leu Glu Ala Tyr Glu Glu Asp Leu Leu Arg Pro 
            740                 745                 750         


Gln Ala Gln Leu Ser Thr Val Ala Ala Glu Thr Glu Lys Leu Asp His 
        755                 760                 765             


Met Leu Gln Asp Ile Arg Met Glu Val Ser Gly Gly Leu Glu Asn Gln 
    770                 775                 780                 


Ala Glu Ile Tyr Ala Met Leu Lys Leu Leu Asp Ala Lys Ala Leu Asn 
785                 790                 795                 800 


Glu Leu Leu His Gln Leu Ile Arg Tyr Arg Thr Ser Ile Ser Cys Ser 
                805                 810                 815     


Leu Gly Ala Ser Asn Pro Asp Tyr Phe Lys Asp Phe Ser Glu Ile Glu 
            820                 825                 830         


Glu Leu Ile Asn Leu Val Ala Tyr Thr Lys Pro Val Leu Val Lys Glu 
        835                 840                 845             


Glu Asn Tyr Ile Glu Val Leu Glu His Asp Phe Ser Ile Phe Met Glu 
    850                 855                 860                 


Gly Glu Pro Ser Asp Tyr Glu Asp Leu Tyr Val Gln Ser Asp Leu Asn 
865                 870                 875                 880 


Thr Thr Val Leu His Arg Asn Ile Ala Asn Met Gly Tyr Thr Gly Val 
                885                 890                 895     


Met Ala Leu Tyr Ser Asn Ile Phe Lys Asn Ser Tyr Arg Val Thr Arg 
            900                 905                 910         


Ala Asp Tyr Gln Lys Tyr Lys Asn Met Lys Thr Thr Glu Asp Lys Glu 
        915                 920                 925             


Glu Ser Val Ile Ala Ala Lys Gln Lys Lys Leu Gln Glu Met His Glu 
    930                 935                 940                 


Lys Phe Val Lys Lys Gln Arg Ile Ser Asn Phe Glu Arg Gln Gln Tyr 
945                 950                 955                 960 


Lys Asp Ala Leu Val Glu Val Gln Asn Tyr Asn His Leu Lys Arg Lys 
                965                 970                 975     


Val Thr Phe Asp Ser Met Tyr Glu Ile Tyr Gln Ile His Ala Gln Ile 
            980                 985                 990         


Leu Gly Arg Leu Ala Ser Phe Ala  Glu Asp Trp Glu Arg  Asp Met Arg 
        995                 1000                 1005             


Phe Met  Leu Thr Ala Leu Val  Glu Glu Gly Lys Ile  Asn Thr Asp 
    1010                 1015                 1020             


Ile Glu  Lys Leu Phe Tyr Lys  Gly Arg Ile Val Gly  Lys Ile Lys 
    1025                 1030                 1035             


Lys Gly  Phe Glu Cys Gly Cys  Leu Pro Phe 
    1040                 1045             


<210>  1263
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1263

Met Lys Leu Thr Gln Ser Arg Gln Ser Lys Gly Ala Gln Phe Phe Arg 
1               5                   10                  15      


Asp Val Ser Lys Gly Gln Leu Val Leu Asn Asn Asn Ile Asp Asn Thr 
            20                  25                  30          


Asp Asn Val Ile Gln Ser Leu Pro Tyr Glu Lys Ser Tyr Ile Gly Arg 
        35                  40                  45              


Ile Leu Tyr Lys Ser Ser Asn Ser Asp Lys Asp Asn Asp Gln Asn Pro 
    50                  55                  60                  


Phe Asn Ser Phe Val Arg Gln Leu Val Lys Asn Gln Asn Lys Glu Arg 
65                  70                  75                  80  


Lys Leu Thr Ser Tyr Ile Asn Leu Asn Asp Lys Asn Asn Lys Lys Leu 
                85                  90                  95      


Ser Lys Asp Asp Phe Lys Asn Gln Ile Asn Thr His Leu Ser Phe Tyr 
            100                 105                 110         


Gly Arg Asn Leu Lys Val Asp Ala Asp Ser Pro Thr Leu Lys Glu Ile 
        115                 120                 125             


Leu Leu Gln Tyr Tyr Asp Gly Asn Asn Asp Ala Glu Asn Glu Leu Lys 
    130                 135                 140                 


Lys Leu Ala Asn Tyr Ile Ser Asn Leu Ala Lys Lys Lys Thr Glu Lys 
145                 150                 155                 160 


Leu Lys Lys Ser Ile Lys Asn Asn Lys Ile Pro Phe Glu Pro Asp Gly 
                165                 170                 175     


Glu Lys Leu Lys Leu Thr Ser Asp Lys Met Lys Leu Leu Phe Asp Phe 
            180                 185                 190         


Leu Lys Lys Asp Gly Val Glu Leu Thr Ser Tyr Glu Lys Phe Gln Lys 
        195                 200                 205             


Asp Tyr Lys Phe Ser Asp Leu Ala Asn Lys Ile Glu Ser Ile Ile Ser 
    210                 215                 220                 


Asn Asp Lys Asn Ser Val Asp Lys Lys Pro Phe Pro Thr Lys Lys Ile 
225                 230                 235                 240 


Tyr Gln Thr Val Ser Asp Tyr Asp Tyr Asp Phe Arg Lys Lys Asn Glu 
                245                 250                 255     


Asp Asn Asp Leu Tyr Leu Phe Tyr Ala Lys Glu Val Lys Asn Tyr Phe 
            260                 265                 270         


Lys Arg Leu Phe Ile Asp Lys Lys Leu Ser Lys Lys Gln Tyr Glu Glu 
        275                 280                 285             


Ile Lys Ser Gln Asn Tyr Lys Ser Glu Lys Tyr Ile Phe Gly Gln Val 
    290                 295                 300                 


Lys Arg Tyr Ile Ile Asn Gln Leu Val Gln Gly Leu Ile Leu Tyr Gly 
305                 310                 315                 320 


Lys Ile Met His Tyr Cys Tyr Asp Thr Asp Ala Lys Gln Phe Asn Val 
                325                 330                 335     


Glu Ile Asn Ser Asp Thr Leu Thr Tyr Ile Gln Val Glu Glu Ala Phe 
            340                 345                 350         


Lys Lys Gln Ile Tyr Leu Ser Leu Ser Trp Ala Ile Thr Arg Leu Asn 
        355                 360                 365             


Tyr Phe Phe Asn Tyr Gly Ser Gln Asn Glu Glu Asn Leu Asp Lys Asp 
    370                 375                 380                 


Lys Lys Glu Gly Asp Ile Leu Leu Ala Lys Thr Phe Arg Asp Lys Phe 
385                 390                 395                 400 


Tyr Glu Lys Val Phe Asn Asn Asn Glu Lys Asp Asp Asp Gly Ile Ser 
                405                 410                 415     


Pro Lys Asp Glu Leu Tyr Ala Lys Ile Ser Thr Cys Phe Ala Ile Asn 
            420                 425                 430         


Ser Lys Asp Asn Asn Asp Asp Asp Ile Lys Lys Leu Leu Glu Asp Cys 
        435                 440                 445             


Cys Ser Ser Val Ala Asn Ile Arg His Asn Val Phe His Phe Lys Lys 
    450                 455                 460                 


Glu Asn Ile Phe Glu Ile Leu Glu Glu Ile Lys Leu Asp Ser Gln Ile 
465                 470                 475                 480 


Ser Lys Glu Leu Leu Asn Arg Asp Ile Leu Asn Ile Gln Lys Cys Phe 
                485                 490                 495     


Lys Glu Gln Ile Arg Ser Thr Ala Leu Thr Asp Tyr Tyr Ser Phe Glu 
            500                 505                 510         


Leu Leu Glu Lys Val Phe Lys Asn Glu Lys Leu Glu Phe Phe Leu Tyr 
        515                 520                 525             


Ser Ser Gln Tyr Pro Met Met Pro Ser Phe Lys Lys Ile His Lys Arg 
    530                 535                 540                 


Gly Cys Asn Ile Ser Lys Ser Pro Asn Gln Thr Lys Glu Ile Lys Trp 
545                 550                 555                 560 


Leu Ile Glu Leu Asp Ser Glu Ile Asp Asn Glu Gly Lys Leu Ala Tyr 
                565                 570                 575     


Lys Asn Leu Leu Gln Leu Ile Tyr Tyr His Ser Phe Leu Pro Ala Ile 
            580                 585                 590         


Lys Lys Asp Glu Lys Leu Val Thr Glu Phe Ile Asn Lys Thr Lys Gln 
        595                 600                 605             


Trp Asn Lys Thr Lys Ser Ile Ala Ser Gln Lys Ala Lys Lys Ala Lys 
    610                 615                 620                 


Asn Lys Lys Ile Asn Tyr Tyr Glu Phe Lys Tyr Ser Asn Met Pro Arg 
625                 630                 635                 640 


Phe Glu Tyr Gly Ile Pro Leu Lys Asp Tyr Leu Glu Glu Leu Gln Arg 
                645                 650                 655     


Gln Gln Ser Ile Arg Glu Asn Asp Glu Asp Lys Lys Asp Lys Asp Asn 
            660                 665                 670         


Tyr Tyr Val Glu Phe Val Gln Asp Ile Phe Val Phe Ala Phe Asp Ser 
        675                 680                 685             


Tyr Leu Leu Lys Ile Ile Ser Ala Tyr Asp Cys Tyr Glu Glu Leu Ile 
    690                 695                 700                 


His Pro Lys Leu Lys Thr Lys Glu Glu Ser Lys Glu Thr Leu Glu Lys 
705                 710                 715                 720 


Leu Phe Asn Glu Ser Asn Pro Ile Leu Lys Ile Lys Thr Asn Leu Asn 
                725                 730                 735     


Pro Asp Thr Lys Phe Ile Thr Met Tyr Pro Phe Phe Arg Leu Leu Asp 
            740                 745                 750         


Gln Arg Glu Leu Asn Ile Leu Leu His Gln Phe Ile Arg Tyr Cys Ser 
        755                 760                 765             


Ser Thr Gln Lys Arg Ser Asn Thr Asn Asp Glu Thr Leu Asn Thr Leu 
    770                 775                 780                 


Thr Gln Ile Glu Glu Leu Ile Thr Leu Val Gln Phe Thr Ile Pro Leu 
785                 790                 795                 800 


Gln Thr Lys Asp Val His Phe Lys Ser Ala Met Glu Lys Tyr Phe Ser 
                805                 810                 815     


Glu Phe Phe Glu Asn Lys Asp Pro Gln Asn Tyr Asp Asp Phe Tyr Leu 
            820                 825                 830         


Gln Gly Ser Lys Lys Glu Glu Asp Lys Leu Val Lys His Arg Ser Met 
        835                 840                 845             


Ser Leu Val Ala Arg Ser Gly Ala Met Ala Leu Tyr Thr Lys Met Phe 
    850                 855                 860                 


Ser Ser Ile Tyr Gln Ile Asn Lys Ser Asp Tyr Glu Lys Tyr Lys Asp 
865                 870                 875                 880 


Ile Tyr Thr Ile Lys Asn Asn Ser Glu Val Thr Lys Ile Glu Glu Met 
                885                 890                 895     


Gln Asn Arg Leu Gln Gln Leu His Glu Lys Leu Val Arg Ile Lys Leu 
            900                 905                 910         


Ile Ser Asp Thr Gln Leu Asn Asp Ile Lys Lys Tyr Gln Thr Leu Ala 
        915                 920                 925             


Lys Gln Ile Lys Glu Tyr Glu Asn Leu Arg His Lys Leu Thr Phe Glu 
    930                 935                 940                 


Ser Leu Tyr Arg Ile His Gln Leu His Val Glu Ile Leu Gly Arg Phe 
945                 950                 955                 960 


Ala Ala Phe Ala Asn Asp Trp Glu Arg Asp Met Phe Phe Met Phe Thr 
                965                 970                 975     


Ala Leu Glu Asn Arg Gly Lys Ile Asn Phe Lys Leu Lys Pro Ile Phe 
            980                 985                 990         


Asn Arg Gly Lys Val Val Gly Asn  Leu Asn Asn Lys Leu  Lys Asp Asp 
        995                 1000                 1005             


Ala Arg  Lys Leu Phe Phe Glu  Leu Cys Trp Ser Asn  Glu Ile Tyr 
    1010                 1015                 1020             


Asp Lys  Asp Lys Asp Asp Asn  Ser Asn Gly Asp Tyr  Ile Tyr Asp 
    1025                 1030                 1035             


Arg Leu  Leu Ile Arg Asn Tyr  Cys Ala His Leu Asn  His Met Thr 
    1040                 1045                 1050             


Gln Phe  Lys Lys Asn Asn Glu  Thr Gln Pro Ser Ile  Ile Gly Tyr 
    1055                 1060                 1065             


Ile Asn  Lys Leu Arg Val Leu  Leu Ala Tyr Asp Ile  Lys Arg Gln 
    1070                 1075                 1080             


Asn Ala  Val Thr Lys Ala Val  Lys Glu Ile Leu Glu  Lys His Tyr 
    1085                 1090                 1095             


Lys Val  Lys Leu Thr Leu Lys  Arg Ser Asp Asp Asn  Pro Asp Lys 
    1100                 1105                 1110             


Phe Val  Ile Ala Asn Leu Glu  Ser Asp Glu Ile Thr  His Leu Lys 
    1115                 1120                 1125             


Asn Leu  Lys Asn Pro Val Ile  Ile Glu Asp Asn Asp  Lys Phe Met 
    1130                 1135                 1140             


Ile Ser  Leu Ile Arg Lys Leu  Leu Ile Phe Lys Phe  Glu Ser Ala 
    1145                 1150                 1155             


Asn Val  Lys 
    1160     


<210>  1264
<211>  1179
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1264

Met Gly Ser Gly Lys Tyr Arg Ile Thr Lys Ile Ala Arg Lys Trp Asp 
1               5                   10                  15      


Lys Asn Glu Asn Trp Glu Lys Ile Ile Leu Lys Arg Ile Val Asp Asn 
            20                  25                  30          


Lys Lys Ile Lys Tyr Val Asn Glu Asn Asn Asn Lys Asp Val Asp Ile 
        35                  40                  45              


Thr Asp Thr Tyr Tyr Ser Ile Leu Ser Lys Asn Asn Ser Lys Phe Leu 
    50                  55                  60                  


Gly Ser Glu Glu Gln Phe Ile Phe Lys Val Asn Lys Met Lys Arg Asn 
65                  70                  75                  80  


Ile Lys Asn Asp Cys Val Ile Ile Lys Asp Tyr Thr Glu Glu Glu Phe 
                85                  90                  95      


Glu Lys Phe Asp Lys Lys Ile Phe Phe Ser Arg Lys Ile Lys Val Asn 
            100                 105                 110         


Asn Glu Asp Arg Glu Lys Ile Cys Arg Asn Phe Tyr Glu Asp Glu Arg 
        115                 120                 125             


Glu Ile Met Lys Lys Arg Leu Glu Glu Ala Lys Asn Phe Asn Asn Ile 
    130                 135                 140                 


Ile Phe Lys Ile Cys Asn Glu Ile Phe Asn Leu Glu Tyr Ile Asn Tyr 
145                 150                 155                 160 


Thr Asp Glu Lys Ile Tyr Lys Ile Phe Gln Glu Lys Ile Gly Phe Glu 
                165                 170                 175     


Asp Ile Lys Asn Leu Lys Glu Val Phe Lys Gln Gln Lys Lys Gly Leu 
            180                 185                 190         


Glu Thr Asp Lys Leu Leu Ala Ile Ser Phe Asn Lys Asn Arg Asn Asn 
        195                 200                 205             


Val Leu Leu Glu Phe Ile Gln Gln Ile Val Lys Gln Glu Phe Glu Asn 
    210                 215                 220                 


Lys Glu Glu Leu Lys Asn Trp Phe Ser His Glu Gly Glu Lys Tyr Cys 
225                 230                 235                 240 


Lys Glu Ile Phe Lys Ile Tyr Ser Asn Met Ser Gln Lys Glu Lys Tyr 
                245                 250                 255     


Ser Lys Leu Leu Gly His Asn Asp Lys Ser Thr Ala Ser Tyr Ser Glu 
            260                 265                 270         


Lys Arg Glu Thr Leu Gln Arg Arg Leu Lys Leu Gly Asp Tyr Ser Lys 
        275                 280                 285             


Tyr Asp Leu Lys Lys Tyr Tyr Gln Lys Asp Tyr Lys Glu Lys Ala Ile 
    290                 295                 300                 


Lys Glu Leu Lys Asp Lys Asn Lys Glu Glu Phe Glu Arg Glu Ile Glu 
305                 310                 315                 320 


Glu Ile Ile Lys Lys Asn Tyr Lys Ile Asp Lys Leu Cys Asp Glu Ile 
                325                 330                 335     


Ser Asn Leu Glu Phe Ser Phe Val Glu Ser Lys Lys Glu Asn Lys Asp 
            340                 345                 350         


Arg Met Ser Glu Ile Ile Val Lys Ile Lys Glu His Tyr Lys Lys Asn 
        355                 360                 365             


Val Asn Val Glu Glu Glu Leu Lys Asn Lys Glu Lys Tyr Ile Leu Ser 
    370                 375                 380                 


Leu Ile His Asn Tyr Val Lys Gly Arg Tyr Gly Lys Cys Leu Glu Leu 
385                 390                 395                 400 


Gln Gln Lys Glu Asn Val Asp Phe Glu Asn Leu Gly Lys Arg Ile Lys 
                405                 410                 415     


Glu Ile Phe Asp Ser Asn Glu Val Thr Glu Lys Leu Lys Lys Ser Ile 
            420                 425                 430         


Ile Asn Lys Val Asn Asn Tyr Lys Ile Phe Glu Thr Lys Phe Gln Asn 
        435                 440                 445             


Pro Asn Ile Glu Ser Ser Asp Asp Leu Glu Ile Leu Lys Ala Glu Glu 
    450                 455                 460                 


Thr Phe Leu Asn Lys Leu Ser Thr Ala Val Ser Lys Val Gly Tyr Thr 
465                 470                 475                 480 


Leu Asn Ile Leu Leu Asp Thr Arg Thr Thr Ser Lys Lys Met Asn Lys 
                485                 490                 495     


Lys Lys Ile Lys Asn Pro Asp Ile Leu Ala Gly Tyr Asn Val Thr Ile 
            500                 505                 510         


Glu Leu Leu Pro Tyr Cys Ser Phe Glu Ile Leu Tyr Asn Val Tyr Pro 
        515                 520                 525             


Glu Ile Lys Lys Asp Ile Glu Leu Leu Lys Gly Met Val Leu Phe Ile 
    530                 535                 540                 


Gln Glu Phe Arg Gln Lys Ile Leu His Pro Ser Gln Leu Leu Gly Ser 
545                 550                 555                 560 


Asn Val Lys Lys Ser Ile Ser Ile Lys Glu Lys Asp Thr Ile Val Lys 
                565                 570                 575     


Ile His Glu Asp Asn Lys Asp Asn Glu Lys Arg Glu Met Tyr Asn Lys 
            580                 585                 590         


Glu Lys Ile Arg Ser Tyr Phe Glu Asp Ile Leu Glu Lys Ile Pro Asp 
        595                 600                 605             


Tyr Phe Ile Glu Lys Tyr Glu Ser Asp Asn Val Phe Asn Ile Tyr Arg 
    610                 615                 620                 


Asp Phe Gly Val Lys Ile Met Glu Val Val Lys Asn Phe Asn Phe Lys 
625                 630                 635                 640 


Glu Asn Asn Thr Ile Asp Tyr Leu Phe Pro Lys Phe His Lys Ile Tyr 
                645                 650                 655     


Lys Arg Met Cys Lys Leu Glu Asn Ile Asp Asp Arg Gln Asn Gly Ala 
            660                 665                 670         


Arg Lys Tyr Leu Leu Gln Thr Ile Tyr Tyr Tyr Tyr Phe Gln Tyr Glu 
        675                 680                 685             


Ile Glu Asn Asp Lys Asn Asn Ile Ser Lys Tyr Leu Asn Leu Tyr Arg 
    690                 695                 700                 


Asn Lys Ile Lys Val Lys Lys Ile Ser Tyr Ser Tyr Ile Thr Asp Asn 
705                 710                 715                 720 


Lys Ala Val Asn Asn Lys Asn Ile Glu Ile Leu Tyr Arg Asn Ile Gln 
                725                 730                 735     


Arg Glu Gly Met Leu Asn Ser Arg Leu Leu Gln Met Asn Asn Glu Trp 
            740                 745                 750         


Val Glu Phe Ile Val Val Gln Phe Ser Glu Phe Leu Ala Asn Lys Lys 
        755                 760                 765             


Leu Asn Trp Ile Leu Asp Asn Leu Ser Glu Tyr Lys Lys Lys Glu Lys 
    770                 775                 780                 


Leu Asp Glu Asn Asp Lys Asn Arg Leu Leu Lys Ile Leu Lys Gln Lys 
785                 790                 795                 800 


Met Asn Lys Lys Ile Thr Tyr Ser Asn Asp Ser Tyr Ala Phe Ile Ser 
                805                 810                 815     


Leu Ala Gln Phe Leu Asp Leu Lys Glu Ile Ser His Leu Ile His Asp 
            820                 825                 830         


Ile Lys Lys Phe Ile Gln Phe Arg Glu Lys Asn Val Ser Lys Tyr Lys 
        835                 840                 845             


Pro Glu Lys Asn Lys Leu Tyr Ile Lys Glu Leu Arg Lys Val Leu Tyr 
    850                 855                 860                 


Ile Leu Lys Val Met Leu Glu His Lys Glu Arg Val Ile Gln Lys His 
865                 870                 875                 880 


Tyr Leu Glu Ser Tyr Asp Glu Asn Ile Ser Ile Ile Tyr Gly Lys Asp 
                885                 890                 895     


Ile Glu Arg Lys Asp Ile Lys Asp Ile Lys Ile Lys Ile Lys Asn Glu 
            900                 905                 910         


Asn Gln Glu Val Ile Asn Gln Pro Leu Tyr Lys Ser Gly Asn Asp Glu 
        915                 920                 925             


Asn Ser Ser Trp Ile Val Leu Tyr Gly Ile Glu Gln Ala Lys Arg Asn 
    930                 935                 940                 


Gly Thr Phe Lys Phe Phe Glu Gly Phe Phe Asn Leu Asn Asp Asp Ile 
945                 950                 955                 960 


Lys Leu Cys Lys Glu Asn Ile Glu Lys Tyr Glu Glu Leu Tyr Asn Glu 
                965                 970                 975     


Lys Glu Glu Asn Gln Arg Lys Val Asp Glu Tyr Ile Ser Ser Glu Glu 
            980                 985                 990         


Asn Asn Asn Ile Asp Glu Ile Lys  Glu Ile Asn Asn Asn  Lys Gln Leu 
        995                 1000                 1005             


Phe Tyr  Tyr Tyr Lys Asn Met  Ile Tyr Gly Asp Gly  Leu Lys Lys 
    1010                 1015                 1020             


Gly Tyr  Asp Phe Ile Asn Asp  Ile Tyr Ser His Tyr  Leu Ser Trp 
    1025                 1030                 1035             


Ala Tyr  Arg Val Glu Arg Asp  Cys Lys Ile Tyr Lys  Ile Lys Glu 
    1040                 1045                 1050             


Tyr Glu  Asn Lys Lys Asn Phe  Asn Glu Tyr Lys Phe  Lys Glu Tyr 
    1055                 1060                 1065             


Lys Ser  Ile Lys Asn Phe Arg  Asn Glu Ile Ala His  Phe Asn Tyr 
    1070                 1075                 1080             


Phe Gln  Lys Thr Asn Lys Ser  Leu Leu Glu Leu Leu  Asn Asp Phe 
    1085                 1090                 1095             


Tyr Asp  Ile Phe Asp Tyr Asn  Leu Lys Tyr Gln Arg  Asp Val Gln 
    1100                 1105                 1110             


Asn Val  Ile Asn Asn Ile Phe  Glu Lys Tyr Gln Ile  Val Arg Lys 
    1115                 1120                 1125             


Asp Gly  Gly Pro Val Val Phe  Tyr Cys Lys Thr Asp  Lys Lys Leu 
    1130                 1135                 1140             


Lys Leu  Ser Glu Asn Ile Ile  Pro Lys Lys His Leu  Lys Tyr Pro 
    1145                 1150                 1155             


Glu Ile  Lys Leu Ile His Glu  Lys Tyr Val Glu Phe  Phe Lys Lys 
    1160                 1165                 1170             


Leu Phe  Glu Tyr Lys Lys 
    1175                 


<210>  1265
<211>  1119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1265

Met Lys Gln Leu Lys Glu Val Cys Ala Tyr Ile Arg Val Ser Thr Gly 
1               5                   10                  15      


Lys Gln Glu Glu Leu Ser Pro Asp Ser Gln Leu Arg Leu Ile Lys Glu 
            20                  25                  30          


Tyr Ala Gln Ala His Asp Met Leu Leu Thr His Val Tyr Met Glu Glu 
        35                  40                  45              


His Gly Ile Ser Gly Lys Ser Ser Glu Lys Arg Pro Ala Phe Gln Glu 
    50                  55                  60                  


Met Ile Ala Ala Cys Lys Asp Lys Ser His Pro Tyr Asp Ala Val Leu 
65                  70                  75                  80  


Leu Trp Lys Phe Ser Arg Phe Ala Arg Asn Gln Asp Glu Ala Thr Tyr 
                85                  90                  95      


Tyr Lys Ser Ile Leu Arg Lys Lys Cys Asn Val Asp Val Ile Ser Ile 
            100                 105                 110         


Ser Glu Pro Ile Ile Glu Gly Met Tyr Gly Arg Leu Ile Glu Met Val 
        115                 120                 125             


Ile Glu Trp Ser Asp Glu Phe Tyr Leu Val Asn Leu Ser Gly Glu Val 
    130                 135                 140                 


Met Arg Gly Met Thr Gln Asn Ala Leu Asn Gly Gly Tyr Asn Ser Asn 
145                 150                 155                 160 


Pro Pro Ile Gly Tyr Thr Lys Lys Arg Gly Glu Ile Pro Gln Val Asp 
                165                 170                 175     


Pro Glu Arg Ala Glu Leu Val Arg His Ile Phe Arg Met Phe Thr Glu 
            180                 185                 190         


Gln His Met Ser Arg Asn Asp Ile Ala Ser Thr Leu Asn Arg Gln Gly 
        195                 200                 205             


Ile Thr Thr Asn Arg Gly Gly Arg Trp Glu Thr Arg Thr Val Thr Tyr 
    210                 215                 220                 


Ile Leu Glu Asn Pro Phe Tyr Ile Gly Lys Ile Arg Trp Asn Phe Tyr 
225                 230                 235                 240 


Asp Arg Ser Gln Asn Arg Arg Lys Asp Thr Gly Asp Val Ile Leu Ser 
                245                 250                 255     


Asp Gly Gln His Glu Pro Ile Ile Ser Ala Asp Thr Phe Ala Ala Ala 
            260                 265                 270         


Gly Arg Leu Leu Ala Lys Ala Arg Thr Thr Ser Cys Phe Gly Arg Lys 
        275                 280                 285             


Arg Ser Val Val Ala Thr Lys His Trp Leu Ser Ser Met Val Leu Cys 
    290                 295                 300                 


Ser Ser Cys Gly Ala Ser Leu Gly Tyr Asn Lys Gly Ser Gln Lys Lys 
305                 310                 315                 320 


His Ala Ala Pro Phe Phe Gln Cys Trp Lys His Ile Lys Gly Met Cys 
                325                 330                 335     


Asp His Asn Ser Tyr Ile Ser Ala Ala Ala Leu Glu Gln Met Val Ile 
            340                 345                 350         


Asp Ala Ile Ile His Phe Gly Gln Ser Phe Asp Leu Met Tyr His Phe 
        355                 360                 365             


Ser Asp Ala Pro Gln Ala Asp Asp Thr Val Tyr Leu Thr Arg Glu Leu 
    370                 375                 380                 


Ser Lys Leu Ser Glu Lys Glu Arg Arg Ile Lys Asp Ala Tyr Ile Ser 
385                 390                 395                 400 


Gly Ile Asp Ser Leu Glu Glu Tyr Arg Glu Asn Lys Trp Asp Glu Leu 
                405                 410                 415     


Glu Gln Gln Leu Ala Asp Asn His Lys Val Thr Pro Ile Lys Glu Arg 
            420                 425                 430         


Tyr Gln Gln Ile Asp Met Asn His Leu Leu Thr Val Leu Gln Asp Pro 
        435                 440                 445             


Asp Gln Asp Tyr Ile Val Lys Gly Asn Ser Leu Arg Arg Leu Met Asn 
    450                 455                 460                 


Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe Phe 
465                 470                 475                 480 


Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys Lys 
                485                 490                 495     


Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys Leu 
            500                 505                 510         


Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser Phe 
        515                 520                 525             


Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala Ile 
    530                 535                 540                 


Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile Ser 
545                 550                 555                 560 


Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys Gln 
                565                 570                 575     


Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu Ala 
            580                 585                 590         


Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro Val 
        595                 600                 605             


Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp Gly 
    610                 615                 620                 


Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn Asp 
625                 630                 635                 640 


Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn Gln 
                645                 650                 655     


Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln Phe 
            660                 665                 670         


Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val Asp 
        675                 680                 685             


Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu Ile 
    690                 695                 700                 


Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met Glu 
705                 710                 715                 720 


Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly Phe 
                725                 730                 735     


Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala Leu 
            740                 745                 750         


Tyr Ser Phe Cys Lys Gln Lys Phe Lys Val Asp Gly Lys Glu Tyr Met 
        755                 760                 765             


Ala Gly Ile Tyr Tyr Asp Gly Glu Asn Leu Ile Pro Asn Arg Asn Ile 
    770                 775                 780                 


Ile Arg Ala Asn Met Tyr Gly Asn Thr Ser Cys Leu Lys Pro Cys Met 
785                 790                 795                 800 


Asp Arg Ile Thr Leu Lys Glu Ile Arg Thr Met Tyr Ala Asp Gln Asn 
                805                 810                 815     


Lys Leu Asp Leu Val Leu Lys Glu Gly Val Cys His Thr Glu Glu Glu 
            820                 825                 830         


Gln Lys Ala Tyr Arg Glu Tyr Gln Asn Glu Lys Asn Arg Ile Glu Leu 
        835                 840                 845             


Phe Asp Val Cys Thr Tyr Thr Gln Ile Leu Asn Asp Met Gln Ala Arg 
    850                 855                 860                 


Leu Ile Gly Trp Ser Tyr Met Arg Glu Arg Asp Leu Met Tyr Tyr Gln 
865                 870                 875                 880 


Leu Gly Tyr Tyr Tyr Thr Lys Leu Phe Trp Thr Asp Ser Ile Ser Glu 
                885                 890                 895     


Glu Asp Ala Arg Arg Arg Leu Val Gly Asn Leu Val Asn Val Glu Asp 
            900                 905                 910         


Gly Ala Ile Leu Tyr Gln Ile Leu Ala Phe Asn Ser Tyr Asn Leu Pro 
        915                 920                 925             


Ile Ile Ala Asn Lys Asn Asn Thr Val Thr Leu Leu Lys Asp Glu Gly 
    930                 935                 940                 


Ser Ile Gly Gly Lys Ala Ile Thr Ala Phe Phe Lys Asn Tyr Glu Asn 
945                 950                 955                 960 


Ala Glu Met Ile Tyr Glu Glu Ala Leu Asp Leu Phe Glu Asn Met Asp 
                965                 970                 975     


Glu His Ala Ala Ile Ile Asn Thr Arg Asn Tyr Ile Glu His Phe Lys 
            980                 985                 990         


Tyr Phe Ile Lys Ser Asp Arg Ser  Met Met Asp Leu Tyr  Ser Glu Ile 
        995                 1000                 1005             


Tyr Asp  Arg Phe Phe Arg His  Asp His Asn Arg Lys  Lys Asn Val 
    1010                 1015                 1020             


Pro Asp  Ser Leu Lys Asn Val  Leu Ala Asp Asn Phe  Met Ile Val 
    1025                 1030                 1035             


Asp Ile  Asp Met Glu Leu Gly  Ser Lys Lys Val Gly  Glu Lys Lys 
    1040                 1045                 1050             


Lys Gly  Phe Arg Glu His Lys  Ala Ala Arg Ile Glu  Phe Thr Asp 
    1055                 1060                 1065             


Ser Gly  Ile Arg Ser Thr Asp  Met Thr Tyr Thr Ile  Lys Pro Asp 
    1070                 1075                 1080             


Ile Lys  Asp Asn Lys Lys Asp  Lys Lys Val Leu Val  Pro Ala Arg 
    1085                 1090                 1095             


Ser Glu  Val Phe Leu Lys Gln  Phe Arg Lys Ile Leu  Glu Tyr Arg 
    1100                 1105                 1110             


Ile Gln  Asp Lys Ile Gln 
    1115                 


<210>  1266
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1266

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Asn Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Glu Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Arg Val Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Val 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Lys Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Lys Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Lys Ile Pro Tyr Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Lys Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Leu Lys Glu Leu Lys Glu Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn Tyr Thr Met Gln Gln Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Lys Lys Asp Glu Lys Phe Asn Asp Glu Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Lys Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Lys Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Lys  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  1267
<211>  1153
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1267

Met Pro Ile Ile Lys Lys Phe Gly Arg Ser Thr Ser Ser Leu Thr Glu 
1               5                   10                  15      


Arg Thr Leu Ile Leu Gly Ala Lys Arg Thr Glu Glu His Gly Ser Val 
            20                  25                  30          


Arg Lys Ile Pro Glu Phe Leu Thr His Asp Ala Glu Ala Leu Leu Gly 
        35                  40                  45              


Gln Trp Ala Ser Ala Met Asp Lys Val Ala Ser Lys Pro Lys Gly Arg 
    50                  55                  60                  


Asp Lys Pro Ser Ala Phe Gln Arg Ser Phe Arg Glu Asp Leu Gly Ser 
65                  70                  75                  80  


Ala Ile Trp Ala Asp Leu Thr Ser Ala Asp Gly Pro Phe Ala Arg Leu 
                85                  90                  95      


Asp Glu Lys Ala Arg Asp Ile Leu His Lys Lys Trp Asp Arg Arg Ile 
            100                 105                 110         


His Pro Tyr Pro Asp Gly Thr Ala Ala Glu His Lys Pro Ala Ser Pro 
        115                 120                 125             


Lys Gly Arg Leu Tyr Ser Met Phe Ala Gly Glu Val Gly Tyr Gly Ala 
    130                 135                 140                 


Ala Asp Lys Pro Ala Ile Ala Arg Lys Ile Arg Leu His Leu Leu Gly 
145                 150                 155                 160 


Glu Glu Leu Arg Lys Ser Gly Gly Thr Arg Pro Gln Gly His Ala Val 
                165                 170                 175     


Arg Arg Ala Asn Ser Ile Glu Lys Asn Thr Leu Pro Lys Ile Lys Ala 
            180                 185                 190         


Thr Pro Val Pro Asp Trp Asp Asp Ala Asp Ile Val Thr Tyr Arg Arg 
        195                 200                 205             


His Gly Asp Val Ala Lys Ala Ile Arg Val Ala Ala Glu Val Ala Glu 
    210                 215                 220                 


Lys Glu Lys Arg Lys Val Gly Trp Arg Leu Ala Ala Ala Glu Ile Tyr 
225                 230                 235                 240 


Val His Phe Gly Lys Val Phe Thr Asn Gly Gly Arg Met Leu Ser Phe 
                245                 250                 255     


Ala Glu Ala Glu Thr Lys His Pro Gly Leu Thr Gly Leu His Arg Ala 
            260                 265                 270         


Ile Glu Asp Leu Tyr Arg Gln Arg Leu Lys Arg His Leu Lys Asp Pro 
        275                 280                 285             


Lys Leu His Ala Ser Gln Pro Gly Thr Glu Arg Leu Val Ser Val Ile 
    290                 295                 300                 


Leu Pro Glu Asp Phe Asp Ser Leu Leu Arg Ala Leu Gly Asn Arg Arg 
305                 310                 315                 320 


Gln Asn Arg Asp Ile Gly Ala Leu Ile Arg Lys Gly Arg Ile Leu His 
                325                 330                 335     


Tyr Glu Ala Gly Ala Arg Val Asn Arg Asp Asp Val Ala Trp Ile Asn 
            340                 345                 350         


Gln His Trp Pro Asp Asp Thr Thr Lys Ser Arg Tyr Trp Thr Ser Asp 
        355                 360                 365             


Gly Gln Thr Glu Ile Lys Arg His Glu Ile Phe Val Arg Ile Trp Arg 
    370                 375                 380                 


Ser Ala Leu Ala His Ala Asn Arg Thr Leu Ala Asp Trp Leu Asp Pro 
385                 390                 395                 400 


Asp Gly Lys Ala Thr Asp Ile Ala Glu Gly Gly Asn Thr Phe Glu Gln 
                405                 410                 415     


Val Leu Ala Ala Thr Gly Gln Ala Thr Val Val Gln Thr Ala Asn Leu 
            420                 425                 430         


Phe Gly Ser Arg Ala Ala Ala Leu Glu Ser His Asp Ala Ile Gln Asp 
        435                 440                 445             


Leu Ala Arg Leu Val Trp Thr Val Tyr Thr Gln Leu Arg His Asn Ser 
    450                 455                 460                 


Phe His Phe Lys Gly Val Asp Gly Phe Lys Val Ala Leu Thr Pro Lys 
465                 470                 475                 480 


Leu Ala Glu Ile Ala Pro Gly Ala Leu Gln Phe Thr Thr Asn Leu Leu 
                485                 490                 495     


Arg Gly Asp Phe Arg Asp Ser Glu Ala Arg Leu Arg Ala Val Leu Arg 
            500                 505                 510         


Ala Ala Gln Val Glu Gly Phe Leu Asp Arg Gly Arg Leu Ala Glu Ile 
        515                 520                 525             


Trp Ala Ala Leu His Pro Ala Gly Glu Ala Gly Leu Gly Pro Ala Leu 
    530                 535                 540                 


Pro Arg Phe Asn Arg Ile Val Gln Arg Val Asp Gly Thr Gly Ala Ile 
545                 550                 555                 560 


Ala Glu Leu Pro Cys Ala Val Asn Gln Phe Asp Met Ala Asn Pro Ala 
                565                 570                 575     


Ile His Cys Arg Tyr Val Val Thr Lys Leu Leu Tyr Glu Arg Gly Phe 
            580                 585                 590         


Arg Ala Trp Val Ala Met Ala Thr Thr Asp Gln Ile Asn Ala Trp Ile 
        595                 600                 605             


Lys Ser Ala Glu Asp Arg Thr Gln Lys Ala Lys Asp Glu Ile His Gly 
    610                 615                 620                 


His Pro Glu Asp Lys Ala Arg Met Val Gly Ala Leu Arg Leu Arg Asp 
625                 630                 635                 640 


Gly Gln Gly Ile Met Asp Phe Leu Ser Glu Leu Thr Ala Leu Thr Ala 
                645                 650                 655     


Thr Glu Phe Arg Val Gln Ala Gly Tyr Glu Pro Asn Arg Ala Ala Ala 
            660                 665                 670         


Gln Glu Gln Ala Glu Tyr Leu Phe His Leu Gln Cys Asp Val Leu Ala 
        675                 680                 685             


Leu Ala Phe Lys Glu Tyr Ile Arg Ala Ala Arg Leu Gly Trp Leu Ser 
    690                 695                 700                 


Asp Thr Leu Lys Pro Asp Arg Val Ala Arg Gly Val Leu Ser Asp Val 
705                 710                 715                 720 


Asp Lys Leu Ala Asp Pro Lys Ala Thr Pro Asp Phe Glu Asp Trp Gln 
                725                 730                 735     


Ala Gly Ile Tyr Ala Val Leu His Leu Val Pro Val Asp Glu Val Gly 
            740                 745                 750         


Arg Leu Leu His Gln Leu Arg Arg Trp Ala Asn Gly Gln Pro Ala Asp 
        755                 760                 765             


Glu Thr Ser Val Lys Ile Glu Arg Leu Leu Glu Leu Tyr Leu Asp Met 
    770                 775                 780                 


His Asp Asp Lys Phe Glu Gly Gly Val Pro Leu His Asp His Pro Asp 
785                 790                 795                 800 


Leu Gln Ala Leu Phe Glu Thr Pro Asp Leu Leu Ala Gln Val Leu Pro 
                805                 810                 815     


Gln Val Gly Ala Thr Glu Asp Glu Arg Arg Arg Val Pro Leu Arg Gly 
            820                 825                 830         


Leu Arg Glu Met Leu Arg Phe Gly Asn Leu Arg Ile Leu Lys Gly Val 
        835                 840                 845             


Phe Ala Lys Ala Pro Ile Thr Thr Ala Gly Val Ala Lys Leu Ala Glu 
    850                 855                 860                 


Tyr Glu Lys Ser Arg Ala Asp Gly Leu Gly Gly Ile Asp His Ala Gln 
865                 870                 875                 880 


Gln Ile Arg Gln Lys Arg His Glu Thr Leu Ala Lys Leu Arg Met Leu 
                885                 890                 895     


Gly Pro Asp Ser Tyr Gly Asp Val Arg Asp Tyr Leu Phe Val Thr Lys 
            900                 905                 910         


Arg Ile Ile Arg His Arg Arg Leu Ala Asn His Val Arg Leu Val Asn 
        915                 920                 925             


His Val Arg Val Asn Gln Ile Leu Met Ser Val Leu Gly Arg Phe Ala 
    930                 935                 940                 


Asp Cys Ala Gly Leu Phe Glu Arg Asp Leu Tyr Phe Thr Leu Leu Ala 
945                 950                 955                 960 


Leu Ile His Glu Leu Gly Gln Lys Pro Glu Ala Val Phe Asp Ala Lys 
                965                 970                 975     


Ala Leu Gly Lys Phe Glu Asp Gly Gln Ile Leu Thr Ala Leu Asp Arg 
            980                 985                 990         


Asn Lys Thr Pro Leu Pro Ala Ser  Ile Ala Cys Glu Leu  Gln Arg His 
        995                 1000                 1005             


Phe Gly  Leu Asp Ala Lys Gly  Ala Gly Pro Asn Arg  Lys Arg Arg 
    1010                 1015                 1020             


Asn Asp  Phe Ala His Phe Asn  Leu Leu Arg Ser Lys  Thr Pro Ile 
    1025                 1030                 1035             


Asn Leu  Thr Ala Ala Met Asn  Asp Ala Arg Ala Leu  Leu Ser His 
    1040                 1045                 1050             


Asp Arg  Lys Leu Lys Asn Ala  Val Ser Ala Ser Ile  Val Thr Leu 
    1055                 1060                 1065             


Leu Glu  Arg Glu Gln Ile Val  Ala His Trp Asn Met  Gly Thr Asp 
    1070                 1075                 1080             


His Gln  Leu Ala Asp Ala Val  Ile Gly Thr Arg Arg  Ile Val His 
    1085                 1090                 1095             


Leu Lys  Ser Ala Glu Leu Ala  Glu Asn Leu Arg Asp  Lys Arg Phe 
    1100                 1105                 1110             


Leu Thr  Leu Ile Ala Gln Leu  Phe Asn Gly Arg Val  Asn Asn Leu 
    1115                 1120                 1125             


Pro Asp  Asp Ile Ala Ala Leu  Asn Arg Pro Gly Ile  Glu Ala Leu 
    1130                 1135                 1140             


Ala Ala  Arg Val Thr Gly Gly  Gly Gly Arg 
    1145                 1150             


<210>  1268
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1268

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Asn Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Glu Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Gln 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Arg Leu Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Ile Lys Arg Ile Phe Glu Tyr Gln Asn Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Arg Val Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Val 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Lys Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Lys Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Lys Ile Pro Tyr Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asn Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Lys Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Leu Lys Glu Leu Lys Glu Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn Tyr Thr Met Gln Gln Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Lys Lys Asp Glu Lys Phe Asn Asp Glu Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Lys Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Lys  Glu Leu Cys 
    1130                 1135                 1140             


Glu Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Lys  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  1269
<211>  972
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1269

Met Leu Gly Asp Lys Ile Glu His Ser Ile Asn Glu Ser Val Val Lys 
1               5                   10                  15      


His Tyr Gln Glu Ala Cys Lys Ala Val Glu Glu Lys Asp Ile Pro Trp 
            20                  25                  30          


Ile Lys Tyr Ile Ser Asp His Val Met Ser Val Tyr Ser Ser Lys Asn 
        35                  40                  45              


Arg Val Asp Leu Asp Lys Leu Ser Leu Pro Tyr Leu Ala Lys Asn Thr 
    50                  55                  60                  


Trp Asn Thr Trp Ile Ser Phe Ile Ala Met Lys Tyr Val Asp Met Gly 
65                  70                  75                  80  


Lys Gly Val Tyr His Phe Ala Met Ser Asp Val Asp Lys Val Gly Lys 
                85                  90                  95      


Gln Asp Asn Leu Ile Ile Gly Gln Ile Asp Pro Lys Phe Ala Asp Gly 
            100                 105                 110         


Ile Ser Ser Phe Asp Tyr Glu Arg Ile Lys Ala Glu Asp Asp Leu His 
        115                 120                 125             


Arg Ser Met Ser Gly Tyr Ile Ala Phe Ala Val Asn Asn Phe Ala Arg 
    130                 135                 140                 


Ala Ile Cys Ser Asp Glu Phe Arg Lys Glu Asp Ser Gln Glu Asp Val 
145                 150                 155                 160 


Leu Thr Ile Gly Leu Asp Glu Ile Pro Leu Tyr Asp Asn Val Lys Arg 
                165                 170                 175     


Lys Leu Leu Gln Tyr Phe Gly Gly Ala Ser Asn Trp Asp Asp Ser Ile 
            180                 185                 190         


Met Asp Ile Ile Asp Asp Lys Asp Leu Ala Ala Cys Ile Lys Glu Asn 
        195                 200                 205             


Leu Tyr Val Ala Arg Asn Val Asn Phe His Phe Ala Gly Ser Glu Lys 
    210                 215                 220                 


Val Gln Lys Lys His Asp Asp Ile Leu Glu Glu Ile Val Arg Lys Glu 
225                 230                 235                 240 


Thr Gly Asp Ile Gly Lys His Tyr Arg Lys Val Phe Tyr Ser Asn Asn 
                245                 250                 255     


Val Ala Val Phe Tyr Arg Asp Glu Asp Ile Ile Lys Leu Met Asn His 
            260                 265                 270         


Leu Tyr Gln Lys Glu Lys Pro Tyr Gln Ala Gln Ile Pro Ser Tyr Asn 
        275                 280                 285             


Lys Val Ile Ser Lys Thr Tyr Leu Pro Asp Leu Ile Phe Met Leu Leu 
    290                 295                 300                 


Lys Gly Lys Asn Arg Thr Lys Ile Ser Asp Pro Ser Ile Met Asn Met 
305                 310                 315                 320 


Phe Arg Gly Thr Phe Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Asn Asp 
                325                 330                 335     


Phe Leu Gln Ala Ser Asn Leu Lys Glu Met Phe Arg Glu Gly Leu Lys 
            340                 345                 350         


Asn Asn Val Lys Asn Lys Lys Ser Glu Lys Pro Tyr Gln Asn Phe Met 
        355                 360                 365             


Gln Arg Phe Glu Glu Leu Glu Asn Met Gly Met Asp Phe Gly Glu Ile 
    370                 375                 380                 


Cys Gln Gln Ile Met Thr Asp Tyr Glu Gln Gln Asn Lys Gln Lys Lys 
385                 390                 395                 400 


Lys Thr Ala Thr Ala Val Met Ser Glu Lys Asp Lys Lys Ile Arg Thr 
                405                 410                 415     


Leu Asp Asn Asp Thr Gln Lys Tyr Lys His Phe Arg Thr Leu Leu Tyr 
            420                 425                 430         


Val Gly Leu Arg Glu Ala Phe Ile Ile Tyr Leu Lys Asp Glu Lys Asn 
        435                 440                 445             


Lys Glu Trp Tyr Glu Phe Leu Arg Glu Pro Val Lys Arg Glu Gln Pro 
    450                 455                 460                 


Glu Glu Lys Glu Phe Val Asn Lys Trp Lys Leu Asn Gln Tyr Ser Asp 
465                 470                 475                 480 


Cys Ser Glu Leu Ile Leu Lys Asp Pro Leu Ala Ala Ala Trp Tyr Val 
                485                 490                 495     


Ala Ala His Phe Ile Asn Gln Ala Gln Leu Asn His Leu Ile Gly Asp 
            500                 505                 510         


Ile Lys Asn Tyr Ile Gln Phe Ile Ser Asp Ile Asp Arg Arg Ala Lys 
        515                 520                 525             


Ser Thr Gly Asn Pro Val Ser Glu Ser Thr Glu Ile Gln Ile Glu Arg 
    530                 535                 540                 


Tyr Arg Lys Ile Leu Arg Val Leu Glu Phe Ala Lys Phe Phe Cys Gly 
545                 550                 555                 560 


Gln Ile Thr Asn Val Leu Thr Asp Tyr Tyr Gln Asp Glu Asn Asp Phe 
                565                 570                 575     


Ser Thr His Val Gly His Tyr Val Lys Phe Glu Lys Lys Asn Met Glu 
            580                 585                 590         


Pro Ala His Ala Leu Gln Ala Phe Ser Asn Ser Leu Tyr Ala Cys Gly 
        595                 600                 605             


Lys Glu Lys Lys Lys Ala Gly Phe Tyr Tyr Asp Gly Met Asn Pro Ile 
    610                 615                 620                 


Val Asn Arg Asn Ile Thr Leu Ala Ala Met Tyr Gly Asn Lys Lys Leu 
625                 630                 635                 640 


Leu Glu Asn Ala Met Asn Pro Val Thr Glu Gln Asp Ile Arg Lys Tyr 
                645                 650                 655     


Tyr Ser Leu Met Ala Glu Leu Asp Ser Thr Leu Lys Asn Gly Ala Val 
            660                 665                 670         


Cys Lys Ser Glu Asp Glu Gln Lys Asn Leu Arg His Phe Gln Asn Leu 
        675                 680                 685             


Lys Asn Arg Ile Glu Leu Val Asp Val Leu Thr Leu Ser Glu Leu Val 
    690                 695                 700                 


Asn Asp Leu Val Ala Gln Leu Ile Gly Trp Val Tyr Ile Arg Glu Arg 
705                 710                 715                 720 


Asp Met Met Tyr Leu Gln Leu Gly Leu His Tyr Ile Lys Leu Tyr Phe 
                725                 730                 735     


Thr Asp Ser Val Ser Glu Asp Ser Tyr Leu Arg Thr Leu Asp Leu Glu 
            740                 745                 750         


Glu Gly Ser Val Ala Asp Gly Ala Val Leu Tyr Gln Ile Ala Ser Leu 
        755                 760                 765             


Tyr Ser Phe Asn Leu Pro Met Tyr Val Lys Ser Asn Lys Ser Ser Val 
    770                 775                 780                 


Tyr Cys Lys Lys His Ala Asn Ser Val Gly Ala Lys Phe Asp Ile Phe 
785                 790                 795                 800 


Glu Lys Lys Tyr Cys Asn Arg Asp Gly Thr Val Ile Glu Asn Gly Leu 
                805                 810                 815     


Cys Leu Phe Glu Asn Ile Lys Leu His Asp Asp Leu Ala Glu Phe Arg 
            820                 825                 830         


Asp Tyr Leu Ala His Phe Lys Tyr Phe Ala Lys Leu Asp Lys Ser Ile 
        835                 840                 845             


Leu Glu Leu Tyr Ser Lys Val Tyr Asp Ser Phe Phe Ser Tyr Asn Ile 
    850                 855                 860                 


Lys Leu Lys Lys Ser Val Ser Tyr Val Phe Thr Asn Ile Leu Leu Ser 
865                 870                 875                 880 


Tyr Phe Ile Asn Ala Lys Leu Ser Phe Ser Leu Cys Gly Ile Ser Asp 
                885                 890                 895     


Tyr Lys Pro Ser Arg Asn Glu Ile Val Gln Arg Arg Ser Ala Asn Ile 
            900                 905                 910         


Ser Ile Glu Ser Val Gln Thr Asp Tyr Phe Thr Tyr Lys Leu Arg Ser 
        915                 920                 925             


Ile Val Lys Asn Lys Asn Gly Val Glu Ser Ile Glu Asn Asp Asp Arg 
    930                 935                 940                 


Lys Cys Glu Val Val Asn Ile Ala Ala Arg Asp Lys Glu Phe Val Asp 
945                 950                 955                 960 


Glu Val Cys Asn Val Ile Lys Tyr Asn Ser Asp Lys 
                965                 970         


<210>  1270
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (552)..(552)
<223>  Xaa can be any naturally occurring amino acid

<400>  1270

Met Lys Leu Thr Gln Ser Arg Gln Ser Lys Gly Ala Gln Phe Phe Arg 
1               5                   10                  15      


Asp Val Ser Lys Gly Gln Leu Val Leu Asn Asn Asn Ile Asp Asn Thr 
            20                  25                  30          


Asp Asn Val Ile Gln Ser Leu Pro Tyr Glu Lys Ser Tyr Ile Gly Arg 
        35                  40                  45              


Ile Leu Tyr Lys Ser Ser Asn Ser Asp Lys Asp Asn Asp Gln Asn Pro 
    50                  55                  60                  


Phe Asn Ser Phe Val Arg Gln Leu Val Lys Asn Gln Asn Lys Glu Arg 
65                  70                  75                  80  


Lys Leu Thr Ser Tyr Ile Asn Leu Asn Asp Lys Asn Asn Lys Lys Leu 
                85                  90                  95      


Ser Lys Asp Asp Phe Lys Asn Gln Ile Asn Thr His Leu Ser Phe Tyr 
            100                 105                 110         


Gly Arg Asn Leu Lys Val Asp Ala Asp Ser Pro Thr Leu Lys Glu Ile 
        115                 120                 125             


Leu Leu Gln Tyr Tyr Asp Gly Asn Asn Asp Ala Glu Asn Glu Leu Lys 
    130                 135                 140                 


Lys Leu Ala Asn Tyr Ile Ser Asn Leu Ala Lys Lys Lys Thr Glu Lys 
145                 150                 155                 160 


Leu Lys Lys Ser Ile Lys Asn Asn Lys Ile Pro Phe Glu Pro Asp Gly 
                165                 170                 175     


Glu Lys Leu Lys Leu Thr Ser Asp Lys Met Lys Leu Leu Phe Asp Phe 
            180                 185                 190         


Leu Lys Lys Asp Gly Val Glu Leu Thr Ser Tyr Glu Lys Phe Gln Lys 
        195                 200                 205             


Asp Tyr Lys Phe Ser Asp Leu Ala Asn Lys Ile Glu Ser Ile Ile Ser 
    210                 215                 220                 


Asn Asp Lys Asn Ser Val Asp Lys Lys Pro Phe Pro Thr Lys Lys Ile 
225                 230                 235                 240 


Tyr Gln Thr Val Ser Asp Tyr Asp Tyr Asp Phe Arg Lys Lys Asn Glu 
                245                 250                 255     


Asp Asn Asp Leu Tyr Leu Phe Tyr Ala Lys Glu Val Lys Asn Tyr Phe 
            260                 265                 270         


Lys Arg Leu Phe Ile Asp Lys Lys Leu Ser Lys Lys Gln Tyr Glu Glu 
        275                 280                 285             


Ile Lys Ser Gln Asn Tyr Lys Ser Glu Lys Tyr Ile Phe Gly Gln Val 
    290                 295                 300                 


Lys Arg Tyr Ile Ile Asn Gln Leu Val Gln Gly Leu Ile Leu Tyr Gly 
305                 310                 315                 320 


Lys Ile Met His Tyr Cys Tyr Asp Thr Asp Ala Lys Gln Phe Asn Val 
                325                 330                 335     


Glu Ile Asn Ser Asp Thr Leu Thr Tyr Ile Gln Val Glu Glu Ala Phe 
            340                 345                 350         


Lys Lys Gln Ile Tyr Leu Ser Leu Ser Trp Ala Ile Thr Arg Leu Asn 
        355                 360                 365             


Tyr Phe Phe Asn Tyr Gly Ser Gln Asn Glu Glu Asn Leu Asp Lys Asp 
    370                 375                 380                 


Lys Lys Glu Gly Asp Ile Leu Leu Ala Lys Thr Phe Arg Asp Lys Phe 
385                 390                 395                 400 


Tyr Glu Lys Val Phe Asn Asn Asn Glu Lys Asp Asp Asp Gly Ile Ser 
                405                 410                 415     


Pro Lys Asp Glu Leu Tyr Ala Lys Ile Ser Thr Cys Phe Ala Ile Asn 
            420                 425                 430         


Ser Lys Asp Asn Asn Asp Asp Asp Ile Lys Lys Leu Leu Glu Asp Cys 
        435                 440                 445             


Cys Ser Ser Val Ala Asn Ile Arg His Asn Val Phe His Phe Lys Lys 
    450                 455                 460                 


Glu Asn Ile Phe Glu Ile Leu Glu Glu Ile Lys Leu Asp Ser Gln Ile 
465                 470                 475                 480 


Ser Lys Glu Leu Leu Asn Arg Asp Ile Leu Asn Ile Gln Lys Cys Phe 
                485                 490                 495     


Lys Glu Gln Ile Arg Ser Thr Ala Leu Thr Asp Tyr Tyr Ser Phe Glu 
            500                 505                 510         


Leu Leu Glu Lys Val Phe Lys Asn Glu Lys Leu Glu Phe Phe Leu Tyr 
        515                 520                 525             


Ser Ser Gln Tyr Pro Met Met Pro Ser Phe Lys Lys Ile His Lys Arg 
    530                 535                 540                 


Gly Cys Asn Ile Ser Lys Ser Xaa Asn Gln Thr Lys Glu Ile Lys Trp 
545                 550                 555                 560 


Leu Ile Glu Leu Asp Ser Glu Ile Asp Asn Glu Gly Lys Leu Ala Tyr 
                565                 570                 575     


Lys Asn Leu Leu Gln Leu Ile Tyr Tyr His Ser Phe Leu Pro Ala Ile 
            580                 585                 590         


Lys Lys Asp Glu Lys Leu Val Thr Glu Phe Ile Asn Lys Thr Lys Gln 
        595                 600                 605             


Trp Asn Lys Thr Lys Ser Ile Ala Ser Gln Lys Ala Lys Lys Ala Lys 
    610                 615                 620                 


Asn Lys Lys Ile Asn Tyr Tyr Glu Phe Lys Tyr Ser Asn Met Pro Arg 
625                 630                 635                 640 


Phe Glu Tyr Gly Ile Pro Leu Lys Asp Tyr Leu Glu Glu Leu Gln Arg 
                645                 650                 655     


Gln Gln Ser Ile Arg Glu Asn Asp Glu Asp Lys Lys Asp Lys Asp Asn 
            660                 665                 670         


Tyr Tyr Val Glu Phe Val Gln Asp Ile Phe Val Phe Ala Phe Asp Ser 
        675                 680                 685             


Tyr Leu Leu Lys Ile Ile Ser Ala Tyr Asp Cys Tyr Glu Glu Leu Ile 
    690                 695                 700                 


His Pro Lys Leu Lys Thr Lys Glu Glu Ser Lys Glu Thr Leu Glu Lys 
705                 710                 715                 720 


Leu Phe Asn Glu Ser Asn Pro Ile Leu Lys Ile Lys Thr Asn Leu Asn 
                725                 730                 735     


Pro Asp Thr Lys Phe Ile Thr Met Tyr Pro Phe Phe Arg Leu Leu Asp 
            740                 745                 750         


Gln Arg Glu Leu Asn Ile Leu Leu His Gln Phe Ile Arg Tyr Cys Ser 
        755                 760                 765             


Ser Thr Gln Lys Arg Ser Asn Thr Asn Asp Glu Thr Leu Asn Thr Leu 
    770                 775                 780                 


Thr Gln Ile Glu Glu Leu Ile Thr Leu Val Gln Phe Thr Ile Pro Leu 
785                 790                 795                 800 


Gln Thr Lys Asp Val His Phe Lys Ser Ala Met Glu Lys Tyr Phe Ser 
                805                 810                 815     


Glu Phe Phe Glu Asn Lys Asp Pro Gln Asn Tyr Asp Asp Phe Tyr Leu 
            820                 825                 830         


Gln Gly Ser Lys Lys Glu Glu Asp Lys Leu Val Lys His Arg Ser Met 
        835                 840                 845             


Ser Leu Val Ala Arg Ser Gly Ala Met Ala Leu Tyr Thr Lys Met Phe 
    850                 855                 860                 


Ser Ser Ile Tyr Gln Ile Asn Lys Ser Asp Tyr Glu Lys Tyr Lys Asp 
865                 870                 875                 880 


Ile Tyr Thr Ile Lys Asn Asn Ser Glu Val Thr Lys Ile Glu Glu Met 
                885                 890                 895     


Gln Asn Arg Leu Gln Gln Leu His Glu Lys Leu Val Arg Ile Lys Leu 
            900                 905                 910         


Ile Ser Asp Thr Gln Leu Asn Asp Ile Lys Lys Tyr Gln Thr Leu Ala 
        915                 920                 925             


Lys Gln Ile Lys Glu Tyr Glu Asn Leu Arg His Lys Leu Thr Phe Glu 
    930                 935                 940                 


Ser Leu Tyr Arg Ile His Gln Leu His Val Glu Ile Leu Gly Arg Phe 
945                 950                 955                 960 


Ala Ala Phe Ala Asn Asp Trp Glu Arg Asp Met Phe Phe Met Phe Thr 
                965                 970                 975     


Ala Leu Glu Asn Arg Gly Lys Ile Asn Phe Lys Leu Lys Pro Ile Phe 
            980                 985                 990         


Asn Arg Gly Lys Val Val Gly Asn  Leu Asn Asn Lys Leu  Lys Asp Asp 
        995                 1000                 1005             


Ala Arg  Lys Leu Phe Phe Glu  Leu Cys Trp Ser Asn  Glu Ile Tyr 
    1010                 1015                 1020             


Asp Lys  Asp Lys Asp Asp Asn  Ser Asn Gly Asp Tyr  Ile Tyr Asp 
    1025                 1030                 1035             


Arg Leu  Leu Ile Arg Asn Tyr  Cys Ala His Leu Asn  His Met Thr 
    1040                 1045                 1050             


Gln Phe  Lys Lys Asn Asn Glu  Thr Gln Pro Ser Ile  Ile Gly Tyr 
    1055                 1060                 1065             


Ile Asn  Lys Leu Arg Val Leu  Leu Ala Tyr Asp Ile  Lys Arg Gln 
    1070                 1075                 1080             


Asn Ala  Val Thr Lys Ala Val  Lys Glu Ile Leu Glu  Lys His Tyr 
    1085                 1090                 1095             


Lys Val  Lys Leu Thr Leu Lys  Arg Ser Asp Asp Asn  Pro Asp Lys 
    1100                 1105                 1110             


Phe Val  Ile Ala Asn Leu Glu  Ser Asp Glu Ile Thr  His Leu Lys 
    1115                 1120                 1125             


Asn Leu  Lys Asn Pro Val Ile  Ile Glu Asp Asn Asp  Lys Phe Met 
    1130                 1135                 1140             


Ile Ser  Leu Ile Arg Lys Leu  Leu Ile Phe Lys Phe  Glu Ser Ala 
    1145                 1150                 1155             


Asn Val  Lys 
    1160     


<210>  1271
<211>  1354
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1271

Leu Phe Leu Trp Ile Ile Glu Glu Val Ile Tyr Glu Ile Ile Lys Leu 
1               5                   10                  15      


Tyr Lys Asn Leu Lys Glu Glu Ile Ile Met Gly Asn Leu Phe Gly Tyr 
            20                  25                  30          


Lys Lys Trp Tyr Lys Val Asp Lys Thr Ile Lys Asp Lys Lys Gly Lys 
        35                  40                  45              


Glu Ser Thr Ile Lys Gln Glu Val Arg Ile Lys Arg Asn Tyr Thr Val 
    50                  55                  60                  


Asp Arg Tyr Thr Leu Asn Thr Asn Asn Lys Glu Lys Asn Asn Ile Asn 
65                  70                  75                  80  


Asn Glu His Phe Val Asn Gln Phe Ile Glu Tyr Lys Thr Lys Asn Asp 
                85                  90                  95      


Ile Phe Glu Lys Phe Thr Arg Lys Phe His Met Gly Asn Ile Leu Phe 
            100                 105                 110         


Lys Leu Lys Gly Lys Ser Gln Lys Gly Lys Ile Ile Asn Asp Lys Asp 
        115                 120                 125             


Phe Phe Glu Thr Lys Lys Ile Val Leu Asp Lys Glu Val Tyr Gly Gln 
    130                 135                 140                 


Ser Glu Lys Leu Arg Asn Glu Lys Gly Ile Thr Lys Gln Asp Ile Leu 
145                 150                 155                 160 


Lys Glu Ile Ile Asp Lys Gly Ile Asp Lys Ser Asn Asp Lys Ile Leu 
                165                 170                 175     


Val Lys Thr Lys Phe Gly Lys Glu Ile Thr Ile Asn Phe Thr Asp Glu 
            180                 185                 190         


Asp Lys Lys Asn Lys Asn Glu Tyr Gln Ile Thr Leu Lys Ile Ile Pro 
        195                 200                 205             


Glu Asn Glu Leu Lys Ile Lys Arg Glu Val Tyr Gly Val Phe Lys Ile 
    210                 215                 220                 


Ile Asn Met Asp Leu Tyr Gln Ile Ile Lys Glu Ile Ile Lys Asn Glu 
225                 230                 235                 240 


Val Gln Lys Val Phe Gly Asn Arg Tyr Tyr Glu Glu Tyr Leu Arg Glu 
                245                 250                 255     


Lys Leu Leu Lys Asp Asp Lys Ile Gly Asp Ile Leu Thr Asn Phe Met 
            260                 265                 270         


Glu Ile Arg Lys Lys Thr Lys Ser Asn Leu Glu Ile Met Gly Phe Val 
        275                 280                 285             


Lys Phe Tyr Leu Asn Val Gly Gly Asp Lys Lys Lys Ser Glu Asn Lys 
    290                 295                 300                 


Lys Ile Phe Val Glu Lys Ile Leu Asn Ile Asn Val Asp Leu Thr Val 
305                 310                 315                 320 


Glu Asp Ile Val Asp Phe Ile Val Lys Glu Leu Lys Phe Trp Asn Ile 
                325                 330                 335     


Thr Lys Arg Ile Glu Lys Leu Gln Glu Lys Thr Val Asn Arg Ala Asp 
            340                 345                 350         


Glu Asp Ile Lys Asn Thr Tyr Val Asn Thr Tyr Val Leu Leu Asp Lys 
        355                 360                 365             


His Glu Lys Phe Lys Lys Tyr Asn Arg Asn Lys Lys Asp Thr Ile Val 
    370                 375                 380                 


Lys Ser Phe Ile Lys Asp Ile Lys Asp Asn Thr Met Lys Gln Lys Ile 
385                 390                 395                 400 


Asn Gln Ile Leu Arg Lys Phe Lys Ile Glu Glu Leu Ile Glu Lys Leu 
                405                 410                 415     


Arg Ile Glu Asn Lys Asn Phe Asp Thr Glu Ile Phe Arg Ile Phe Lys 
            420                 425                 430         


Asp His Tyr Gln Glu Met Phe Ser Ser Glu Lys Phe Glu Glu Lys Ser 
        435                 440                 445             


Asp Glu Glu Lys Glu Leu Tyr Lys Ile Ile Tyr Arg Tyr Leu Lys Gly 
    450                 455                 460                 


Arg Ile Glu Lys Ile Leu Ile Asn Glu Gln Lys Val Arg Leu Lys Lys 
465                 470                 475                 480 


Met Glu Lys Ile Glu Val Glu Lys Ile Leu Asn Glu Ser Val Leu Ser 
                485                 490                 495     


Glu Lys Ile Leu Lys Arg Val Lys Gln Tyr Thr Leu Glu His Ile Met 
            500                 505                 510         


Tyr Leu Gly Lys Leu Val His Asn Asn Ile Asp Met Thr Thr Val Asn 
        515                 520                 525             


Thr Asn Asp Phe Ser Arg Leu His Ala Lys Glu Glu Leu Asp Leu Glu 
    530                 535                 540                 


Leu Ile Thr Phe Phe Ala Ser Thr Asn Met Glu Leu Asn Lys Ile Phe 
545                 550                 555                 560 


Ser Arg Glu Asn Ile Asn Asn Asp Glu Asn Ile Asp Phe Phe Gly Gly 
                565                 570                 575     


Asp Arg Glu Lys Asn Tyr Val Leu Asp Lys Lys Asn Leu Asn Ser Lys 
            580                 585                 590         


Ile Glu Ile Ile Arg Asp Leu Asp Phe Ile Asp Asn Lys Asn Asn Ile 
        595                 600                 605             


Thr Asn Asn Phe Ile Ser Lys Phe Thr Lys Ile Gly Thr Asn Glu Arg 
    610                 615                 620                 


Asn Arg Ile Leu His Ala Ser Ser Lys Glu Arg Asp Leu Gln Gly Thr 
625                 630                 635                 640 


Gln Asp Asp Tyr Asn Lys Val Ile Asn Ile Ile Gln Asn Leu Lys Ile 
                645                 650                 655     


Ser Asp Glu Glu Val Ser Lys Ala Leu Asn Leu Asp Val Val Phe Lys 
            660                 665                 670         


Asp Lys Lys Asn Ile Ile Thr Lys Ile Asn Asp Ile Glu Ile Ser Glu 
        675                 680                 685             


Glu Asn Asn Ser Val Ile Lys Tyr Leu Pro Ser Phe Ser Lys Val Leu 
    690                 695                 700                 


Pro Glu Ile Leu Asn Leu Tyr Lys Asn Lys Asn Lys Asn Asn Pro Phe 
705                 710                 715                 720 


Asp Thr Thr Glu Thr Glu Arg Ile Met Leu Asn Ala Leu Ile Tyr Val 
                725                 730                 735     


Asn Lys Glu Leu Tyr Lys Lys Leu Ile Leu Glu Lys Asn Leu Glu Glu 
            740                 745                 750         


Asn Glu Ser Lys Asn Lys Phe Leu Lys Glu Leu Lys Lys Asn Leu Gly 
        755                 760                 765             


Gly Thr Asp Glu Ile Asp Glu Asn Ile Ile Glu Ser Tyr Tyr Lys Asn 
    770                 775                 780                 


Thr Gln Ile Ser Ala Ser Lys Gly Asn Asn Lys Ala Ile Lys Lys Tyr 
785                 790                 795                 800 


Gln Lys Lys Ile Ile Glu Cys Tyr Ile Lys Tyr Leu Glu Glu Asn Tyr 
                805                 810                 815     


Arg Glu Leu Phe Asp Phe Ser Asp Phe Lys Met Asn Ile Gln Glu Ile 
            820                 825                 830         


Lys Lys Gln Ile Lys Glu Ile Asn Asp Asn Lys Thr Tyr Lys Arg Ile 
        835                 840                 845             


Thr Ile Lys Thr Ser Asp Lys Ser Ile Val Ile Asn Asp Asp Phe Glu 
    850                 855                 860                 


Tyr Ile Ile Ser Ile Phe Ala Leu Leu Asn Asn Asn Ile Phe Ile Asn 
865                 870                 875                 880 


Lys Ile Arg Asn Arg Phe Phe Ala Thr Ser Val Trp Leu Asn Thr Ser 
                885                 890                 895     


Glu Tyr Gln Asn Ile Ile Asp Ile Leu Asp Glu Ile Met Gln Leu Asn 
            900                 905                 910         


Thr Leu Arg Asn Glu Cys Ile Thr Glu Asn Trp Asn Leu Asn Leu Glu 
        915                 920                 925             


Glu Phe Ile Gln Lys Met Lys Glu Ile Glu Lys Asp Phe Asp Asp Phe 
    930                 935                 940                 


Lys Ile Gln Thr Lys Lys Glu Ile Phe Asn Asn Tyr Tyr Glu Asp Ile 
945                 950                 955                 960 


Lys Asn Asn Ile Leu Thr Glu Phe Lys Asp Asp Ile Asn Gly Cys Asp 
                965                 970                 975     


Val Leu Glu Lys Lys Leu Glu Lys Ile Val Ile Phe Asp Asp Glu Thr 
            980                 985                 990         


Lys Phe Glu Ile Asp Lys Lys Ser  Asn Ile Leu Gln Asp  Glu Gln Arg 
        995                 1000                 1005             


Lys Leu  Ser Asn Ile Asn Lys  Lys Asp Leu Lys Lys  Lys Val Asp 
    1010                 1015                 1020             


Gln Tyr  Ile Lys Asp Lys Asp  Gln Glu Ile Lys Ser  Lys Ile Leu 
    1025                 1030                 1035             


Cys Arg  Ile Ile Phe Asn Ser  Asp Phe Leu Lys Lys  Tyr Lys Lys 
    1040                 1045                 1050             


Glu Ile  Asp Asn Leu Val Glu  Ser Thr Glu Ser Lys  Asn Glu Asn 
    1055                 1060                 1065             


Lys Phe  Glu Lys Ile Tyr Tyr  Pro Glu Glu His Lys  Asn Glu Leu 
    1070                 1075                 1080             


Tyr Ile  Tyr Lys Lys Asn Leu  Phe Leu Asn Ile Gly  Asn Pro Asn 
    1085                 1090                 1095             


Phe Asp  Lys Ile Tyr Gly Leu  Ile Ser Lys Asp Ile  Lys Ile Thr 
    1100                 1105                 1110             


Asp Ala  Lys Phe Leu Phe Asn  Ser Asp Gly Lys Asn  Ile Arg Asn 
    1115                 1120                 1125             


Asn Lys  Ile Ala Glu Ile Asp  Val Ile Leu Lys Lys  Leu Asn Asn 
    1130                 1135                 1140             


Lys Leu  Asn Gly Tyr Ser Lys  Glu Tyr Lys Glu Lys  Tyr Ile Glu 
    1145                 1150                 1155             


Lys Leu  Lys Glu Asn Asn Asp  Phe Phe Ala Lys Asn  Ile Gln Asn 
    1160                 1165                 1170             


Glu Asn  Tyr Asn Ser Phe Glu  Glu Phe Lys Glu Asp  Tyr Asn Lys 
    1175                 1180                 1185             


Val Ser  Glu Tyr Lys Lys Ile  Arg Asp Leu Val Glu  Phe Asn Tyr 
    1190                 1195                 1200             


Leu Asn  Lys Ile Glu Ser Tyr  Leu Ile Asp Ile Asn  Trp Lys Leu 
    1205                 1210                 1215             


Ala Ile  Gln Met Ala Arg Phe  Glu Arg Asp Met His  Tyr Ile Val 
    1220                 1225                 1230             


Asn Gly  Leu Lys Lys Leu Asn  Phe Ile Asn Leu Asn  Gly Tyr Asn 
    1235                 1240                 1245             


Thr Gly  Ile Ser Arg Thr Tyr  Pro Lys Tyr Asn Asp  Ser Asp Ser 
    1250                 1255                 1260             


Asn Lys  Asn Cys Lys Lys Phe  Tyr Glu Thr Thr Ala  Tyr Tyr Lys 
    1265                 1270                 1275             


Phe Phe  Asp Asp Lys Ser Tyr  Arg Glu Phe Glu Asp  Ile Cys Tyr 
    1280                 1285                 1290             


Glu Phe  Gly Ile Asp Leu Arg  Lys Asn Ser Asn Ile  Gln Ala Lys 
    1295                 1300                 1305             


Glu Glu  Arg Asn Ile Arg Asn  Tyr Ile Ser His Phe  Tyr Ile Val 
    1310                 1315                 1320             


Arg Asn  Pro Phe Ala Asp Tyr  Ser Ile Ala Glu Gln  Ile Asp Arg 
    1325                 1330                 1335             


Val Ser  Asn Leu Leu Ser Tyr  Ser Thr Arg Tyr Asn  Asn Ser Thr 
    1340                 1345                 1350             


Tyr 
    


<210>  1272
<211>  1322
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1272

Met Val Pro Asn Arg Arg Gly Lys Ser Met Lys Ile Ser Lys Val Asp 
1               5                   10                  15      


His Lys Arg Ala Ala Val Ser Val Lys Asn Lys Lys Thr Lys Gly Ile 
            20                  25                  30          


Leu Tyr Asp Asp Pro Thr Gln Gly Lys Asn Pro Ile Arg Asp Ile Gly 
        35                  40                  45              


Lys Gln Tyr Asp Val Leu Ser Asn Arg Ala Glu Gly Leu Tyr Ser Ile 
    50                  55                  60                  


Leu Asn Pro Ala Lys Gly Lys Glu Lys Glu Glu Val Lys Glu Phe Arg 
65                  70                  75                  80  


Asn Ser Ile Asn Lys Leu Ser Lys Arg Leu Leu Lys Glu Cys Ser Gly 
                85                  90                  95      


Asn Asp Pro Asp Arg Thr Val Lys Glu Gln Thr Arg Leu Leu Thr Ser 
            100                 105                 110         


Asn Ile Met Gly Ser Tyr Ile Pro Thr Lys Gly Glu Leu Tyr Asp Asp 
        115                 120                 125             


Gln Val Glu Arg Leu Ile Ser Glu Tyr Leu Lys Lys Ser Leu Cys Val 
    130                 135                 140                 


Asn Val Ser Val Asp Gly Gln Leu Tyr Tyr Leu Pro Asp Ile Leu Ala 
145                 150                 155                 160 


Asp Tyr Leu Lys Arg Leu Lys Asp Leu Pro Asp Asn Ala Gly Val Ala 
                165                 170                 175     


Glu Phe Ser Gly Ile Ile Glu Ser Thr Gly Ile Lys Lys Ile Glu Ala 
            180                 185                 190         


Leu Leu Gln Val Leu Asn Lys Asp Phe Arg Lys Pro His Arg Lys Glu 
        195                 200                 205             


Asn Thr Ile Lys Ser Ile Glu Gln Gln Val Lys Pro Val Ala Val Ile 
    210                 215                 220                 


Lys Lys Gly Asp Gly Tyr Tyr Leu Ile Pro Ser Asn Ala Glu His Pro 
225                 230                 235                 240 


Lys Lys Lys Tyr Val Phe Ser Phe Met Lys Glu Tyr Val Gly Ser Ser 
                245                 250                 255     


Glu Glu Glu Lys Arg Glu Leu Leu Ile His Met Arg Lys Leu Leu Val 
            260                 265                 270         


Leu Tyr Leu Cys Ser Thr Glu Lys Asn Glu Ala Leu Leu Val Asn Glu 
        275                 280                 285             


Asn Ser Phe Cys Asn Glu Leu Ser Leu Glu Glu Ser Ile Ala Pro Glu 
    290                 295                 300                 


Leu Glu Glu Ser Phe Asp Lys Ile Tyr Glu Leu Glu Met Lys Ser Lys 
305                 310                 315                 320 


Asp Leu Arg Asp Glu Leu Gln Ile Leu Gly Arg Lys Lys Phe Leu Gly 
                325                 330                 335     


Asp Glu Glu Arg Lys Lys Arg Gly Lys Leu Lys Ala Glu Lys Ala Ala 
            340                 345                 350         


Thr Glu Gly Glu Ile Lys Lys Glu Lys Ala Leu Ile Ala Ser Lys Ile 
        355                 360                 365             


Asp Ala Val Leu Val Ser His Phe Arg Leu Ala Ile Lys Gly Glu Asp 
    370                 375                 380                 


Ile Lys Asp Thr Asp Arg Phe Trp Ile Asp Tyr Phe Asp Gly Glu Ala 
385                 390                 395                 400 


Arg Lys Ile Leu Leu Lys Gly His Arg Val Asp Asn Tyr Lys Leu Ser 
                405                 410                 415     


Thr Leu Trp Leu Gly Lys Lys Ile Trp Asn Asn Trp Thr Ala Tyr Met 
            420                 425                 430         


Ala Glu Lys Phe Ile Asp Tyr Gly Lys Ala Val Tyr His Phe Val Leu 
        435                 440                 445             


Pro Asp Leu Leu Ala Gln Asp Met Ser Ser Ile Ser Phe Gly Glu Val 
    450                 455                 460                 


Gln Pro Glu Tyr Arg Glu Gly Ile Ser Ser Phe Glu Tyr Glu Arg Ile 
465                 470                 475                 480 


Lys Ala Lys Glu Asp Phe Glu Arg Arg Thr Ala Val Ala Ile Thr Ser 
                485                 490                 495     


Ala Val Asn Thr Phe Ser Arg Ala Val Leu Glu Arg Ile Pro Val Ser 
            500                 505                 510         


Tyr Asp Glu Arg Thr Lys Gln Lys Lys Glu Glu Asn Asp Ile Leu Phe 
        515                 520                 525             


Val Ser Gln Glu Thr Tyr Phe Pro Ala Leu Tyr Glu Asp Ala Gly Lys 
    530                 535                 540                 


Arg Val Leu Arg Tyr Phe Gly Gly Tyr Ser Thr Trp Lys Asp Asn Glu 
545                 550                 555                 560 


Asp Val Arg Phe Tyr Ala Glu Asp Glu Lys Gly Val Glu Leu Val Asp 
                565                 570                 575     


Ala Val Lys Arg Gln Leu Ala Asp Leu Arg Asn Asn Thr Phe His Tyr 
            580                 585                 590         


Thr Gly Ile Glu Gly Asp Thr Asp Thr Ala Val Ile Arg Glu Leu Phe 
        595                 600                 605             


Asn His Glu Glu Met Gln Phe Ser Gly Thr Val Lys Gln Lys Tyr Tyr 
    610                 615                 620                 


Ser Asn Asn Val Phe Arg Tyr Tyr Gly Gln Lys Glu Thr Glu Glu Leu 
625                 630                 635                 640 


Leu Asn Ile Leu Tyr Lys Lys Pro Ala Phe Val Pro Ser Gln Val Pro 
                645                 650                 655     


Ser Phe Gly Arg Leu Phe Asn Arg Asp Ser Ala Tyr Val His Asp Lys 
            660                 665                 670         


Met Leu Met Gly Lys Gly Arg Gln Arg Ile Ala Gly Lys Gly Pro Glu 
        675                 680                 685             


Glu Val Glu Ile Phe Lys Gly Thr Phe Leu Phe Leu Leu Lys Glu Ile 
    690                 695                 700                 


Tyr Tyr Asn Ala Phe Leu Gln Asp Glu Thr Cys Lys Asp Arg Phe Leu 
705                 710                 715                 720 


Lys Leu Val Phe Gly Gly Asn Ala His Ile Lys Ile Gln Asn Ser Glu 
                725                 730                 735     


Ala Leu Lys Asp Phe Gln Ser Arg Ile Lys Asn Met Gly Gln Asn Val 
            740                 745                 750         


Ser Leu Gly Glu Ile Cys Gln Gln Ile Met Thr Asp Tyr Glu Leu Gln 
        755                 760                 765             


Asn Gln Asp Lys Arg Val His Lys Ser Gly Lys Asn Asp Gln Glu Ile 
    770                 775                 780                 


Tyr Lys His Phe Arg Thr Leu Leu Tyr Leu Tyr Met Arg Glu Ala Phe 
785                 790                 795                 800 


Val Asp Tyr Leu Leu His Ser Asp Lys Ala Glu Leu Phe Arg Phe Val 
                805                 810                 815     


Arg Asn Pro Ser Val Asp Glu Ala Thr Lys Thr Ile Ile Lys Glu Asp 
            820                 825                 830         


Tyr Leu Lys Asp Trp Ser Cys Asn Thr Tyr Ile Gly Ile Met Lys Asp 
        835                 840                 845             


Glu Ser Val Leu Lys Trp Tyr Thr Met Ala His Phe Leu Ile Pro Lys 
    850                 855                 860                 


Gln Leu Asn His Leu Val Gly Ala Leu Lys Ser Tyr Glu Val Tyr Ile 
865                 870                 875                 880 


Lys Asp Ile Glu Arg Arg Ala Ala Asp Thr Gly Asn Arg Lys Ser Trp 
                885                 890                 895     


Glu Ala Ala Glu Ala Glu Ser Thr Lys Ile Arg Glu Ile Ile Lys Ile 
            900                 905                 910         


Leu Thr Phe Ser Met Asn Phe Cys Ala Lys Thr Thr Lys Asn Ile Glu 
        915                 920                 925             


Asp Tyr Phe Ser Ser Glu Glu Glu Tyr Ala Ser Thr Leu Ser Lys Phe 
    930                 935                 940                 


Val Asp Ile Lys Asn Lys Tyr Val Ser Glu Trp Ser Thr Ala Leu Lys 
945                 950                 955                 960 


Ile Phe Cys Asp Thr Thr Thr Ser Val Glu Val Ala Ser Asn Gly Lys 
                965                 970                 975     


Lys Asn Arg Lys Glu Met Arg Leu Gly Ile Tyr His Asp Gly Thr Asn 
            980                 985                 990         


Pro Ile Pro Asn Arg Asn Val Phe  Met Ala Ala Met Tyr  Gly Asp Leu 
        995                 1000                 1005             


Asn Leu  Leu Ser Ala Val Cys  Asp Lys Ala Arg Glu  Asn Asp Ile 
    1010                 1015                 1020             


Lys Asp  Tyr Tyr Arg Lys Gln  Ala Glu Leu Ala Glu  Val Phe Lys 
    1025                 1030                 1035             


Arg Gly  Lys Cys Ile Thr Arg  Glu Glu Gln Glu Ser  Leu Arg Glu 
    1040                 1045                 1050             


Phe Gln  Asn Lys Lys Asn Phe  Ile Glu Met Asn Asp  Leu Leu Ser 
    1055                 1060                 1065             


Tyr Thr  Glu Met Val Asn Asp  Leu Asn Gly Gln Leu  Val Asn Trp 
    1070                 1075                 1080             


Cys Tyr  Phe Arg Glu Arg Asp  Leu Met Tyr Met Gln  Leu Gly Val 
    1085                 1090                 1095             


His Tyr  Thr Lys Leu Phe Phe  Thr Glu Ala Val Pro  Lys Asp Asp 
    1100                 1105                 1110             


Ile Arg  Arg Thr Ile Ala Gly  Glu Gly Phe His Ile  Lys Glu Gly 
    1115                 1120                 1125             


Ala Leu  Leu Tyr Gln Ile Ala  Ala Met Tyr Thr Tyr  Gly Leu Pro 
    1130                 1135                 1140             


Leu Tyr  Gly Phe Asp Lys Lys  Gly Asn Cys Lys Ile  Thr Ile Lys 
    1145                 1150                 1155             


Ala Gly  Val Ala Ser Gly Gly  Cys Ile Gly Ala Phe  Val Lys Asn 
    1160                 1165                 1170             


Tyr Cys  Gly Glu Ser Phe Asn  Asn Pro Val Thr Tyr  Asn Glu Gly 
    1175                 1180                 1185             


Leu Tyr  Phe Phe Glu Asn Ile  Gly Asp His Asp Ser  Ile Val Glu 
    1190                 1195                 1200             


Thr Arg  Asn Tyr Ile Asp His  Phe Lys Tyr Phe Ala  Gly Gln Lys 
    1205                 1210                 1215             


Arg Ser  Ile Leu Glu Leu Tyr  Ser Glu Ile Tyr Glu  Arg Phe Phe 
    1220                 1225                 1230             


Ser Tyr  Ser Val Asn Phe Lys  Lys Ser Val Ser Phe  Ile Leu Pro 
    1235                 1240                 1245             


Asn Ile  Leu Glu Arg Tyr Phe  Val Ile Leu Arg Thr  Val Ile Lys 
    1250                 1255                 1260             


Lys Asp  Asp Arg Lys Gly His  Pro Ile Ala Ser Ile  Ser Val Thr 
    1265                 1270                 1275             


Gly Ala  Ser Ser Ala Lys Leu  Thr Tyr Lys Ile Ala  Lys Asp Glu 
    1280                 1285                 1290             


Gly Gln  Ala Glu Ile Glu Val  Leu Val Pro Ala Arg  Ser Asp Lys 
    1295                 1300                 1305             


Tyr Leu  Ala Thr Val Glu Arg  Leu Leu Met Tyr Arg  Ala Glu 
    1310                 1315                 1320         


<210>  1273
<211>  1103
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1273

Val Lys Phe Ser Lys Val Asn Asn Leu Lys Thr Ala Val Thr Leu Asp 
1               5                   10                  15      


Lys Asn Asn Asp Gly Lys Thr Gly Ile Leu Tyr Arg Asp Pro Ala Arg 
            20                  25                  30          


Lys Glu Arg Ser Val Gln Arg Asp Ile Gly Thr His Val Ser Arg Gln 
        35                  40                  45              


Ile Asp Lys Ser Lys Asn Leu Tyr Arg Leu Phe Asn Ala Ser Gln Glu 
    50                  55                  60                  


Asp Glu Glu Glu Val Pro Glu Leu Phe Phe Ala Asn Arg Leu Asn Glu 
65                  70                  75                  80  


Thr Ile Lys Lys Gln Met Ile Glu Lys Met Val Lys Ser Asp Phe Thr 
                85                  90                  95      


Ala Asp Arg Leu Cys Ser Leu Leu Lys Lys Val Ser Asp Glu Met Gly 
            100                 105                 110         


Tyr Ala Phe Ser Gln Gln Ile Ile Asp Ser Ala Ile Asn Arg Phe Leu 
        115                 120                 125             


Arg Arg Asn Leu Tyr Ile Asn Ala Ala Lys Gly Leu Lys Thr Ala Leu 
    130                 135                 140                 


Met Val Gly Phe Gly Leu Met Pro Gln Asp Gln Leu Thr Ala Glu Asp 
145                 150                 155                 160 


Lys Lys Glu Ile Glu His Phe Leu Ser Val Leu Arg Asp Asp Tyr Glu 
                165                 170                 175     


His Gln Ala Ile Ile Lys His Val Glu Lys Ser Ile Thr His Gln Asn 
            180                 185                 190         


Met Leu Ile Gln Pro Asn Lys Glu Gly Leu Phe Val Pro Ala Glu Ile 
        195                 200                 205             


Pro Gln Ala Gln Asn Arg Ser Lys Asn Glu Lys Glu Ala Phe Glu Arg 
    210                 215                 220                 


Phe Leu Leu Ser Tyr Ala Val Leu Asp Glu Lys Ile Arg His Asp Leu 
225                 230                 235                 240 


Arg Leu Arg Leu Arg Arg Leu Val Asp Leu Tyr Phe Tyr Gly Glu Ser 
                245                 250                 255     


Ala Val Lys Gln Glu Asp Phe Asp Glu Trp Lys Asp His Ala Gly His 
            260                 265                 270         


Lys Gly Asp Thr Met Pro Phe Ser Glu Lys Ala Ser Asp Leu Ile Pro 
        275                 280                 285             


Ile Ile Leu Arg Ala Gln Asp Lys Asn Leu Asp Asp Glu Ala Lys Lys 
    290                 295                 300                 


Glu Ala Lys Glu Lys Ala Lys Glu Ala Lys Thr Asp Ile Phe Arg Tyr 
305                 310                 315                 320 


Leu Arg Glu Glu Asn Thr Ser Arg Tyr Arg Arg Cys Ile Ser Ala Val 
                325                 330                 335     


Lys Asn Ala Val Asn Thr Asp Leu Tyr Phe Glu Asp Met Met Ile Asn 
            340                 345                 350         


Gln Phe Trp Ile His His Ile Glu Asp Ala Val Glu Arg Ile Cys Asp 
        355                 360                 365             


Asn Ile Arg Lys Pro Glu Ser Phe Arg Leu Cys Val Gly Tyr Leu Gly 
    370                 375                 380                 


Glu Lys Val Trp Lys Asp Cys Leu Asn Tyr Leu Ser Ile Lys Tyr Ile 
385                 390                 395                 400 


Ala Ile Gly Lys Thr Val Tyr His Tyr Ala Met Ser Ser Asp Ile Ala 
                405                 410                 415     


Asp Ser Thr Lys Ser Val Thr Leu Gly Lys Ile Ala Pro Asp Lys Met 
            420                 425                 430         


Lys Gly Leu Thr Ser Phe Asp Tyr Glu Gln Ile Lys Ala Glu Glu Thr 
        435                 440                 445             


Leu Gln Arg Ser Leu Ala Val Tyr Val Thr Phe Ala Ala Asn His Leu 
    450                 455                 460                 


Ala Gly Glu Thr Val Lys Arg Glu Asn Lys Ser Gln Lys Glu Asp Phe 
465                 470                 475                 480 


Phe Thr Leu Lys Lys Gly Asp Leu Lys Asp Gln Gln Lys Pro His Leu 
                485                 490                 495     


Arg Arg Asn Ile Phe Gln Phe Phe Gly Gly Gln Ser Arg Trp Gln Asp 
            500                 505                 510         


Phe Pro Phe Glu Lys Tyr Phe Ile Ser Glu Tyr Thr Asp Leu Asp Phe 
        515                 520                 525             


Leu Tyr Asp Leu Gln Gln Ile Leu Tyr Ser Leu Arg Asn Glu Ser Phe 
    530                 535                 540                 


His Phe Asp Thr Arg Asn His Asn Met Gly Asp Trp Asn Gln Pro Leu 
545                 550                 555                 560 


Ile Ile Ala Met Phe Glu Tyr Asp Cys Lys Gln Cys Ser Val Leu Gln 
                565                 570                 575     


Lys Ser Lys Phe Tyr Ser Asn Asn Leu Pro Met Phe Tyr Gly Gln Lys 
            580                 585                 590         


Asp Leu Glu Lys Ile Leu Lys Arg Leu Tyr Glu Val Gln Ala Gly Arg 
        595                 600                 605             


Ala Ser Gln Val Pro Ser Phe Asn Ser Val Phe Val Arg Asn Asn Phe 
    610                 615                 620                 


Lys Glu Phe Ile Arg Asn Asn Leu Gly Trp Asn Ile Asn Phe Thr Glu 
625                 630                 635                 640 


Glu Lys Ser Thr Glu Asn Leu Asp Lys Phe Glu Ser Gly Leu Tyr Tyr 
                645                 650                 655     


Leu Leu Lys Glu Ile Tyr Tyr Asn Leu Phe Leu Gln Gly Lys Gly Leu 
            660                 665                 670         


Thr Gly Asp Tyr Asp Val Lys Lys Gln Phe Ile Asn Trp Ser Arg Lys 
        675                 680                 685             


Lys Thr Asp Glu Glu His Lys Phe Ala Ala Ile Asn Phe Ser Gln Arg 
    690                 695                 700                 


Ile Lys Ser Leu Glu Glu Gly Glu Arg Glu Phe Ser Phe Ser Glu Ile 
705                 710                 715                 720 


Cys Gln Ser Ile Met Thr Glu Tyr Asn Leu Tyr Asn Asn Asn Arg Lys 
                725                 730                 735     


Val Lys Ser Asp Tyr Val Lys Lys Asn His Pro Asp Ser Tyr Ala His 
            740                 745                 750         


Tyr Lys Leu Leu Leu Tyr Lys Gly Ile Arg Glu Val Phe Ala His Tyr 
        755                 760                 765             


Ile Lys Thr Gln Phe Ser Leu Leu Ala Glu Pro Ser Leu Arg Glu Lys 
    770                 775                 780                 


Pro Ala Glu Glu Asp Phe Leu Pro Ser Tyr Thr Thr Gly Ala Tyr Lys 
785                 790                 795                 800 


Glu Leu Ile Asp Arg Val Arg Lys Asn Ile Asp Leu Gln Lys Trp Tyr 
                805                 810                 815     


Ile Leu Gly Arg Phe Leu Asn Ala Arg Gln Ala Asn Leu Leu Ile Gly 
            820                 825                 830         


Gln Val Arg His Tyr Ala Gln Tyr Ser Ser Asp Val Arg Arg Arg Ala 
        835                 840                 845             


Ala Glu Thr Arg Asn Gln Thr Leu Gln Glu Val Ser Lys Lys Glu Leu 
    850                 855                 860                 


Asp Gly Tyr Glu Lys Val Leu Asp Val Cys Ile Lys Leu Ser Gly Met 
865                 870                 875                 880 


Thr Ser Asn Asn Leu Glu Asp Tyr Phe Asp Asp Lys Asp Asp Tyr Ala 
                885                 890                 895     


Lys His Ile Ser His Tyr Leu Ala Phe Thr Glu Asp Ile Pro Gly Val 
            900                 905                 910         


Ser Leu Ser Ala Gln Leu Glu Gly Phe Cys Leu Ser Asn Thr Asp Asp 
        915                 920                 925             


Asp Glu Ser Glu Phe Ala Arg Asn Gly Ile Phe Tyr Asp Glu Met Asn 
    930                 935                 940                 


Pro Ile Ile Asn Lys Asn Ile Leu Tyr Ala Lys Leu Tyr Gly Thr Asp 
945                 950                 955                 960 


Glu Val Leu Ser Ala Ala Leu Lys Asp Arg Lys Val Thr Arg Glu Asp 
                965                 970                 975     


Ile Lys Lys Tyr His Ser Gln Lys Glu Lys Ile Ser Ala Tyr Arg Ser 
            980                 985                 990         


Ser Gly Lys Cys Lys Thr Glu Glu  Glu Gln Lys Asp Leu  Lys Gly Tyr 
        995                 1000                 1005             


Gln Glu  Leu Lys Asn Arg Val  Glu Leu Arg Asn Ile  Val Glu Tyr 
    1010                 1015                 1020             


Glu Glu  Leu Leu Asp Glu Leu  Gln Ser Gln Leu Val  Asp Trp Cys 
    1025                 1030                 1035             


Tyr Leu  Arg Glu Arg Asp Leu  Met Tyr Phe Gln Leu  Gly Phe His 
    1040                 1045                 1050             


Tyr Leu  Cys Leu Asn Gly Thr  Gly Glu Ala Pro Glu  Met Tyr Arg 
    1055                 1060                 1065             


Thr Leu  Glu Tyr Asn Gly Arg  Lys Ile Asp Gly Ala  Ile Leu Tyr 
    1070                 1075                 1080             


Gln Ile  Ala Ala Met Tyr Thr  Ser Gly Val Thr Leu  Tyr Thr Phe 
    1085                 1090                 1095             


Asn Glu  Gly Gln Glu 
    1100             


<210>  1274
<211>  1145
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1274

Met Gly Phe Val Lys Phe Tyr Leu Asn Val Asp Gly Asp Lys Lys Lys 
1               5                   10                  15      


Ser Glu Asn Lys Lys Met Phe Val Glu Lys Ile Leu Asn Ile Asn Val 
            20                  25                  30          


Asp Leu Thr Glu Glu Asp Ile Val Asp Phe Ile Val Lys Glu Leu Lys 
        35                  40                  45              


Phe Trp Asn Ile Thr Lys Arg Ile Glu Lys Leu Gln Glu Lys Thr Val 
    50                  55                  60                  


Asn Arg Thr Asp Arg Asp Ile Lys Asn Thr Tyr Val Asn Thr Tyr Val 
65                  70                  75                  80  


Leu Leu Asp Lys His Glu Lys Phe Lys Lys Tyr Asn Arg Asn Lys Lys 
                85                  90                  95      


Asp Ile Ile Val Lys Ser Phe Ile Lys Asp Ile Arg Asp Asn Thr Met 
            100                 105                 110         


Lys Gln Lys Ile Asn Gln Ile Leu Ser Lys Phe Lys Ile Lys Glu Leu 
        115                 120                 125             


Lys Lys Asn Leu Lys Glu Asn Thr Glu Asn Lys Asn Phe Asp Thr Glu 
    130                 135                 140                 


Ile Phe Gly Ile Phe Lys Thr His Tyr Gln Asn Ile Phe Ser Ser Glu 
145                 150                 155                 160 


Lys Phe Glu Asn Lys Ser Asp Glu Glu Lys Glu Leu His Lys Ile Ile 
                165                 170                 175     


Tyr Arg Tyr Leu Lys Gly Arg Ile Glu Lys Ile Leu Ile Asn Arg Glu 
            180                 185                 190         


Lys Ile Arg Leu Asn Lys Ile Glu Ile Glu Lys Ile Leu Asn Glu Asn 
        195                 200                 205             


Val Leu Ser Lys Lys Ile Leu Lys Arg Val Lys Gln Tyr Ser Leu Glu 
    210                 215                 220                 


Tyr Ile Met Tyr Leu Gly Lys Leu Val His Asn Lys Pro Val Asp Asn 
225                 230                 235                 240 


Lys Ser Val Asp Asn Asn Asn Asn Ile Asp Met Thr Thr Val Asn Thr 
                245                 250                 255     


Asn Tyr Phe Ser Lys Leu His Ala Glu Glu Glu Leu Asp Leu Glu Leu 
            260                 265                 270         


Ile Thr Phe Phe Ala Ser Thr Asn Met Glu Leu Asn Lys Ile Phe Glu 
        275                 280                 285             


Ile Asn Lys Gly Lys Asn Asp Phe Phe Gly Asp Ser Phe Lys Ile Asn 
    290                 295                 300                 


Asp Thr Lys Val Leu Leu Lys Asn Asp Val Thr Ser Ser Lys Leu Tyr 
305                 310                 315                 320 


Ile Leu Lys Asn Leu Asn Phe Ile Asp Asn Glu Asn Lys Val Lys Lys 
                325                 330                 335     


Glu Glu Phe Ile Ser Lys Phe Ile Thr Ile Gly Val Asn Glu Arg Asn 
            340                 345                 350         


Arg Ile Leu His Ala Ser Asn Lys Arg Arg Val Pro Gln Gly Thr Gln 
        355                 360                 365             


Asp Asp Tyr Lys Gly Thr Gln Asp Asp Tyr Asn Lys Val Ile Asn Ile 
    370                 375                 380                 


Ile Gln Asn Leu Lys Ile Ser Asp Glu Glu Val Ser Lys Ala Leu Asn 
385                 390                 395                 400 


Leu Asp Val Val Phe Lys Asp Lys Lys Asn Ile Ile Thr Lys Ile Asn 
                405                 410                 415     


Asp Ile Lys Ile Ser Glu Glu Asn Ser Asn Asp Ile Lys Tyr Leu Pro 
            420                 425                 430         


Ser Phe Ser Lys Ile Leu Pro Lys Ile Leu Asn Leu Tyr Arg Asn Asn 
        435                 440                 445             


Pro Arg Asn Glu Pro Phe Asp Thr Ile Glu Thr Glu Lys Ile Val Leu 
    450                 455                 460                 


Asn Ala Leu Ile Tyr Val Asn Lys Glu Leu Tyr Lys Lys Leu Ile Leu 
465                 470                 475                 480 


Glu Asp Gly Ser Gln Glu Asn Arg Ser Lys Asn Ile Phe Leu Gln Glu 
                485                 490                 495     


Leu Lys Lys Thr Leu Gly Gly Thr Asp Glu Ile Asn Glu Asn Ile Ile 
            500                 505                 510         


Glu Asn Tyr Tyr Lys Asn Ala Gln Ile Ser Ala Ser Lys Gly Asn Asn 
        515                 520                 525             


Lys Val Ile Lys Lys Tyr Gln Lys Lys Val Ile Glu Cys Tyr Ile Gly 
    530                 535                 540                 


Tyr Leu Arg Lys Asn Tyr Glu Glu Leu Phe Asp Phe Ser Asp Phe Lys 
545                 550                 555                 560 


Met Asn Ile Gln Glu Ile Lys Lys Gln Ile Lys Asp Ile Asn Asp Asn 
                565                 570                 575     


Lys Thr Tyr Glu Arg Ile Thr Ile Lys Thr Ile Asp Arg Thr Ile Val 
            580                 585                 590         


Ile Asn Asp Asp Phe Glu Tyr Ile Ile Ser Ile Phe Ala Leu Leu Asn 
        595                 600                 605             


Ser Asn Ala Val Ile Asn Lys Ile Arg Asn Arg Phe Phe Ala Thr Ser 
    610                 615                 620                 


Val Trp Leu Asn Ile Ser Lys Tyr Gln Asn Ile Ile Asn Ile Leu Asp 
625                 630                 635                 640 


Glu Ile Met Gln Ile Asn Ile Leu Lys Ser Glu Tyr Ile Thr Asp Asn 
                645                 650                 655     


Trp Lys Glu Asn Leu Glu Glu Phe Ile Arg Lys Ile Lys Asn Lys Glu 
            660                 665                 670         


Ile Glu Leu His Gln Ser Lys Lys Glu Phe Phe Asp Asn Asn Tyr Lys 
        675                 680                 685             


Glu Ile Lys Asn Asp Ile Val Asn Glu Phe Gln Asp Asn Glu Glu Ile 
    690                 695                 700                 


Lys Lys Ile Phe Asp Asn Asn Leu Lys Glu Ile Thr Glu Phe Arg Asn 
705                 710                 715                 720 


Asn Gly Ala Met Tyr Phe Lys Asn Leu Lys Glu Leu Ser Gln Ile Glu 
                725                 730                 735     


Arg Glu Phe Ile Leu Asp Asn Lys Lys Leu Phe Glu Asp Lys Ile Asp 
            740                 745                 750         


Glu Ile Ile Ile Lys Lys Gln Lys Glu Val Lys Glu Glu Ile Leu Ala 
        755                 760                 765             


Lys Lys Ile Phe Asn Ser Glu Phe Leu Glu Lys Tyr Lys Glu Glu Ile 
    770                 775                 780                 


Asp Asn Leu Val Glu Ser Thr Glu Ser Lys Asn Glu Asn Lys Phe Glu 
785                 790                 795                 800 


Lys Ile Tyr Tyr Pro Glu Glu His Lys Asn Glu Leu Tyr Ile Tyr Lys 
                805                 810                 815     


Lys Asn Leu Phe Leu Asn Ile Gly Asn Pro Asn Phe Asp Lys Ile Tyr 
            820                 825                 830         


Gly Ile Ile Ser Lys Asp Ile Lys Asn Ala Asn Thr Glu Ile Leu Phe 
        835                 840                 845             


Asp Asn Asp Ile Arg Lys Asn Lys Ile Ser Glu Ile Asp Ala Ile Leu 
    850                 855                 860                 


Lys Asn Leu Asn Asp Lys Leu Asn Gly Tyr Ser Asn Asp Tyr Lys Ala 
865                 870                 875                 880 


Lys Tyr Val Asn Glu Leu Lys Glu Asn Asp Asp Phe Phe Ala Lys Asn 
                885                 890                 895     


Met Gln Asn Glu Asn Tyr Ser Ser Phe Gly Glu Phe Glu Lys Asp Tyr 
            900                 905                 910         


Asn Lys Val Ser Glu Tyr Lys Lys Ile Arg Asp Leu Val Glu Phe Asn 
        915                 920                 925             


Tyr Leu Asn Lys Ile Glu Ser Tyr Leu Ile Asp Ile Asn Trp Lys Leu 
    930                 935                 940                 


Ala Ile Gln Met Ala Arg Phe Glu Arg Asp Met His Tyr Ile Val Asn 
945                 950                 955                 960 


Gly Leu Arg Glu Leu Gly Ile Ile Lys Leu Ser Gly Tyr Asn Thr Gly 
                965                 970                 975     


Ile Ser Arg Ala Tyr Pro Lys Arg Asn Gly Ser Asp Gly Phe Tyr Thr 
            980                 985                 990         


Thr Thr Ala Tyr Tyr Lys Phe Leu  Asp Glu Glu Ser Tyr  Lys Lys Phe 
        995                 1000                 1005             


Glu Lys  Ile Cys Tyr Gly Phe  Gly Ile Asp Leu Ser  Glu Asn Ser 
    1010                 1015                 1020             


Glu Ile  Asn Lys Pro Glu Asn  Glu Ser Ile Arg Asn  Tyr Ile Ser 
    1025                 1030                 1035             


His Phe  Tyr Ile Val Arg Asn  Pro Phe Val Asp Tyr  Ser Ile Ala 
    1040                 1045                 1050             


Glu Gln  Ile Asp Arg Val Ser  Asn Leu Leu Ser Tyr  Ser Thr Arg 
    1055                 1060                 1065             


Tyr Asn  Asn Ser Thr Tyr Ala  Ser Val Phe Glu Val  Phe Lys Lys 
    1070                 1075                 1080             


Asp Val  Asp Leu Asn Tyr Asp  Glu Leu Lys Lys Lys  Phe Lys Leu 
    1085                 1090                 1095             


Ile Gly  Asn Asn Asn Ile Leu  Glu Arg Leu Met Arg  Pro Lys Lys 
    1100                 1105                 1110             


Val Ser  Val Leu Glu Leu Glu  Ser Tyr Asn Ser Gly  Tyr Ile Lys 
    1115                 1120                 1125             


Asn Leu  Ile Ile Lys Leu Leu  Thr Lys Ile Glu Asn  Thr Asn Asp 
    1130                 1135                 1140             


Thr Leu  
    1145 


<210>  1275
<211>  1163
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1275

Met Gly Ser Gly Lys Tyr Arg Ile Thr Lys Ile Gly Arg Asp Trp Asp 
1               5                   10                  15      


Glu Asn Lys Lys Arg Ile Ile Leu Lys Arg Val Val Ser Asn Gly Lys 
            20                  25                  30          


Val Lys Tyr Ile Asn Glu Asn Asp Asn Val Asp Val Asp Ile Thr Glu 
        35                  40                  45              


Thr Tyr Tyr Gly Ile Leu Ser Asn Asn Lys Ala Lys Phe Leu Gly Ser 
    50                  55                  60                  


Asn Glu Gln Phe Ile Phe Lys Val Asn Lys Met Lys Arg Asn Ile Lys 
65                  70                  75                  80  


Asn Asp Cys Val Ile Ile Lys Asp Tyr Thr Glu Glu Glu Phe Glu Lys 
                85                  90                  95      


Leu Asp Lys Lys Ile Phe Phe Ser Arg Lys Ile Lys Val Asn Asn Glu 
            100                 105                 110         


Asp Arg Glu Lys Ile Cys Arg Asn Phe Tyr Glu Asp Glu Arg Glu Ile 
        115                 120                 125             


Met Lys Lys Arg Leu Glu Glu Ala Lys Asn Phe Asn Asn Ile Ile Phe 
    130                 135                 140                 


Asn Ile Cys Asn Lys Ile Phe Lys Leu Glu Tyr Ile Asp Tyr Thr Asp 
145                 150                 155                 160 


Glu Lys Val Tyr Glu Ile Phe Gln Lys Glu Ile Lys Phe Glu Asp Ile 
                165                 170                 175     


Lys Asn Leu Lys Glu Ala Phe Lys Gln Gln Glu Asn Gly Leu Glu Thr 
            180                 185                 190         


Asp Lys Leu Leu Thr Ile Ser Phe Asn Lys Lys Arg Ser Asn Val Leu 
        195                 200                 205             


Leu Glu Phe Ile Gln Gln Ile Val Lys Gln Asn Phe Glu Asn Glu Lys 
    210                 215                 220                 


Glu Leu Glu Asn Trp Phe Ser His Asp Gly Glu Lys Tyr Cys Lys Glu 
225                 230                 235                 240 


Ile Phe Lys Ile Tyr Ser Asn Met Ser Gln Lys Glu Lys Tyr Ser Lys 
                245                 250                 255     


Leu Leu Gly His Asn Asp Glu Ser Ile Ala Ser Asp Ser Glu Lys Arg 
            260                 265                 270         


Glu Thr Leu Gln Arg Arg Leu Lys Leu Gly Asp Tyr Ser Lys Tyr Asp 
        275                 280                 285             


Leu Lys Lys Tyr Tyr Gln Lys Asp Tyr Lys Glu Glu Ala Ile Lys Glu 
    290                 295                 300                 


Leu Glu Asp Lys Ser Lys Glu Glu Leu Glu Lys Glu Val Glu Glu Ile 
305                 310                 315                 320 


Ile Lys Lys Asn Tyr Lys Ile Asp Lys Leu Cys Asp Glu Ile Ser Asn 
                325                 330                 335     


Leu Glu Phe Ser Phe Val Asp Ser Lys Lys Glu Asn Lys Asp Lys Met 
            340                 345                 350         


Ser Glu Ile Ile Val Lys Ile Lys Glu His Tyr Lys Asn Asn Val Asn 
        355                 360                 365             


Val Glu Glu Glu Leu Glu Asn Lys Glu Lys Tyr Ile Leu Ser Met Ile 
    370                 375                 380                 


His Asn Tyr Ile Lys Gly Arg Tyr Arg Lys Cys Leu Glu Leu Gln Gln 
385                 390                 395                 400 


Lys Glu Asn Val Asp Phe Glu Asn Leu Gly Lys Arg Ile Lys Glu Ile 
                405                 410                 415     


Phe Asp Ser Asn Lys Val Thr Glu Lys Leu Lys Lys Ser Ile Leu Asn 
            420                 425                 430         


Lys Val Asn Asn Tyr Lys Ile Phe Glu Thr Lys Phe Gln Asn Pro Asn 
        435                 440                 445             


Ile Glu Ser Ser Asp Asp Leu Glu Ile Leu Lys Ala Glu Glu Thr Phe 
    450                 455                 460                 


Leu Asn Lys Leu Ser Thr Ala Val Ser Lys Val Gly Tyr Ile Leu Asn 
465                 470                 475                 480 


Ile Leu Leu Glu Ile His Phe Arg Asn Asp Ile Leu Gln Asp Tyr Asn 
                485                 490                 495     


Gln Val Glu Lys Leu Trp Lys Ser Asp Ser Phe Gln Lys Ile Cys Ala 
            500                 505                 510         


Ile Tyr Pro Glu Ile Asn Asn Asp Glu Lys Leu Leu Lys Gly Met Ile 
        515                 520                 525             


Tyr Phe Ile Gln Gly Leu Arg Gln Gln Val Leu His Pro Lys Ile Leu 
    530                 535                 540                 


Trp Glu Lys Gln Asn Ile Tyr Asn Ala Glu Asn Ile Lys Glu Lys Glu 
545                 550                 555                 560 


Lys Ile Val Ser Val Arg Leu Gln Asn Glu Gly Glu Ala Tyr Asn Lys 
                565                 570                 575     


Lys Gly Ile Gln Asn Tyr Phe Glu Asn Val Leu Lys Lys Ile Pro Asp 
            580                 585                 590         


Tyr Phe Ile Glu Lys Tyr Glu Ser Asn Asn Val Phe Asn Ile Tyr Arg 
        595                 600                 605             


Asn Phe Val Asp Lys Ile Met Glu Val Val Lys Asn Phe Asn Phe Lys 
    610                 615                 620                 


Glu Asn Asn Thr Ile Asp Tyr Leu Phe Pro Lys Phe His Lys Ile Tyr 
625                 630                 635                 640 


Lys Arg Met Cys Lys Leu Glu Asn Ile Asp Asp Arg Gln Asn Gly Ala 
                645                 650                 655     


Arg Lys Tyr Leu Leu Gln Ile Ile Tyr Tyr Tyr Tyr Phe Gln Tyr Glu 
            660                 665                 670         


Ile Glu Asn Asp Lys Asn Asn Ile Ser Lys Tyr Leu Asn Leu Tyr Arg 
        675                 680                 685             


Asn Lys Ile Lys Val Lys Lys Ile Ser Tyr Ser Tyr Ile Thr Asp Asn 
    690                 695                 700                 


Lys Ala Val Asn Asn Lys Asn Ile Glu Ile Leu Tyr Arg Asn Ile Gln 
705                 710                 715                 720 


Arg Glu Gly Met Leu Asn Asn Lys Leu Ser Gln Met Asn Lys Glu Trp 
                725                 730                 735     


Ile Glu Phe Ile Val Val Gln Phe Ser Glu Phe Leu Thr Asn Lys Lys 
            740                 745                 750         


Leu Asn Trp Ile Leu Asp Asn Leu Ser Gly Tyr Lys Lys Lys Glu Lys 
        755                 760                 765             


Leu Asp Glu Asn Asp Lys Asn Arg Leu Leu Lys Ile Leu Lys Gln Lys 
    770                 775                 780                 


Met Asn Lys Lys Ile Ile Tyr Ser Asn Asp Ser Tyr Ala Phe Ile Ser 
785                 790                 795                 800 


Leu Ala Gln Phe Leu Asp Leu Lys Glu Ile Ser Asn Leu Ile His Asp 
                805                 810                 815     


Ile Lys Lys Phe Ile Gln Phe Arg Glu Lys Asn Val Ser Lys Tyr Lys 
            820                 825                 830         


Pro Glu Lys Asn Lys Leu Tyr Ile Lys Glu Leu Arg Lys Val Leu Tyr 
        835                 840                 845             


Ile Leu Lys Val Met Leu Glu His Lys Glu Arg Val Ile Gln Lys His 
    850                 855                 860                 


Tyr Leu Glu Ser Tyr Asp Glu Asn Ile Ser Ile Ile Tyr Gly Lys Asp 
865                 870                 875                 880 


Ile Glu Arg Lys Asp Ile Lys Asp Ile Lys Ile Lys Ile Lys Asn Glu 
                885                 890                 895     


Asn Gln Glu Val Ile Asn Gln Pro Leu Tyr Lys Ser Gly Asn Asp Glu 
            900                 905                 910         


Asn Ser Ser Trp Ile Val Leu Tyr Gly Ile Glu Gln Ala Lys Arg Asn 
        915                 920                 925             


Gly Thr Phe Lys Phe Phe Glu Gly Phe Phe Asn Leu Asn Asp Asp Ile 
    930                 935                 940                 


Lys Leu Cys Lys Glu Asn Ile Glu Lys Tyr Glu Glu Leu Tyr Asn Glu 
945                 950                 955                 960 


Lys Glu Glu Asn Gln Arg Lys Val Asp Glu Tyr Ile Ser Ser Glu Glu 
                965                 970                 975     


Asn Asn Asn Ile Asp Glu Ile Lys Glu Ile Asn Asn Asn Lys Gln Leu 
            980                 985                 990         


Phe Tyr Tyr Tyr Lys Asn Met Ile  Tyr Gly Asp Gly Leu  Lys Lys Gly 
        995                 1000                 1005             


Tyr Asp  Phe Ile Asn Asp Ile  Tyr Ser His Tyr Leu  Ser Trp Ala 
    1010                 1015                 1020             


Tyr Arg  Val Glu Arg Asp Cys  Lys Ile Tyr Lys Ile  Lys Glu Tyr 
    1025                 1030                 1035             


Glu Asn  Lys Lys Asn Phe Asn  Glu Tyr Lys Phe Lys  Glu Tyr Lys 
    1040                 1045                 1050             


Ser Ile  Lys Asn Phe Arg Asn  Glu Ile Ala His Phe  Asn Tyr Phe 
    1055                 1060                 1065             


Gln Lys  Thr Asn Lys Ser Leu  Leu Glu Leu Leu Asn  Asp Phe Tyr 
    1070                 1075                 1080             


Asp Ile  Phe Asp Tyr Asn Leu  Lys Tyr Gln Arg Asp  Val Gln Asn 
    1085                 1090                 1095             


Val Ile  Asn Asn Ile Phe Glu  Lys Tyr Gln Ile Val  Arg Lys Asp 
    1100                 1105                 1110             


Gly Gly  Pro Val Val Phe Tyr  Cys Lys Thr Asp Lys  Lys Leu Lys 
    1115                 1120                 1125             


Leu Ser  Glu Asn Leu Val Pro  Lys Lys His Ser Lys  Tyr Pro Glu 
    1130                 1135                 1140             


Ile Lys  Leu Ile His Glu Lys  Tyr Val Met Phe Phe  Arg Lys Leu 
    1145                 1150                 1155             


Phe Glu  Tyr Lys Lys 
    1160             


<210>  1276
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1276

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys His Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Tyr Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Met 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Glu 
        275                 280                 285             


Asn Val Lys Tyr Val Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Val Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Thr Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Lys Ile Leu Lys Tyr Thr Glu Ser Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Lys 
        915                 920                 925             


Glu Tyr Glu Lys Ala Ile Gly Asn Ile Gln Lys Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu 
945                 950                 955                 960 


Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile Glu 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Ser Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Asn Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asn  Val Glu Lys Arg Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Lys Leu  Lys Gln Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Lys Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Lys Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Glu  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  1277
<211>  960
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1277

Leu Glu Phe Ile Gln Lys Ile Thr Lys Gln Glu Phe Lys Asn Gln Lys 
1               5                   10                  15      


Glu Leu Glu Asn Trp Phe Ser Gln Ser Gly Glu Lys Tyr Cys Lys Glu 
            20                  25                  30          


Ile Phe Lys Ile Tyr Ser Asn Met Ser Gln Lys Glu Lys Tyr Phe Lys 
        35                  40                  45              


Leu Leu Gly His Arg Asn Gln Gly Ile Ala Ser Ile Tyr Asp Glu Lys 
    50                  55                  60                  


Lys Glu Thr Leu Gln Arg Arg Leu Lys Leu Gly Asp Tyr Ser Lys Tyr 
65                  70                  75                  80  


Asp Leu Lys Lys Tyr Tyr Gln Lys Asp Tyr Lys Glu Glu Ala Ile Lys 
                85                  90                  95      


Glu Leu Lys Asp Lys Asn Lys Glu Glu Val Glu Arg Glu Ile Glu Ala 
            100                 105                 110         


Leu Ile Lys Lys Asn Tyr Lys Ile Asp Lys Leu Cys Asp Glu Ile Ser 
        115                 120                 125             


Asn Leu Glu Phe Ser Phe Val Glu Ser Lys Lys Glu Asn Lys Asp Lys 
    130                 135                 140                 


Met Ser Glu Ile Ile Val Lys Ile Lys Glu His Tyr Lys Lys Asn Val 
145                 150                 155                 160 


Asn Val Glu Glu Glu Leu Lys Asn Lys Glu Lys Tyr Ile Phe Ser Leu 
                165                 170                 175     


Ile His Asn Tyr Val Lys Gly Arg Tyr Arg Lys Cys Leu Glu Leu Gln 
            180                 185                 190         


Gln Lys Glu Asn Val Asp Phe Glu Asn Leu Glu Lys Arg Ile Lys Glu 
        195                 200                 205             


Ile Phe Asp Ser Asn Glu Val Thr Lys Lys Leu Lys Lys Ser Ile Ile 
    210                 215                 220                 


Asn Lys Val Asn Ser Tyr Lys Ile Phe Glu Met Lys Phe Gln Asn Pro 
225                 230                 235                 240 


Asn Ile Glu Ser Ser Asp Asp Leu Glu Ile Leu Lys Ala Glu Glu Thr 
                245                 250                 255     


Phe Leu Asn Lys Leu Ser Thr Ala Val Ser Lys Val Gly Tyr Thr Leu 
            260                 265                 270         


Asn Ile Leu Leu Glu Val Ser Ser Glu Lys Asp Ile Leu Glu Asn Tyr 
        275                 280                 285             


Asn Met Val Gly Lys Leu Cys Asn Asn Asn Ser Thr Thr Glu Ile Tyr 
    290                 295                 300                 


Lys Val Tyr Pro Glu Leu Glu Lys Asn Glu Lys Leu Leu Gln Gly Met 
305                 310                 315                 320 


Ile His Phe Ile Gln Gly Leu Arg Gln Gln Ser Leu His Pro Lys Ile 
                325                 330                 335     


Leu Trp Asn Phe Glu Thr Lys Asn Leu Lys Pro Glu Lys Leu Glu Arg 
            340                 345                 350         


Leu Lys Glu Lys Lys Asn Ile Lys Met Arg Asp Cys Val Val His Glu 
        355                 360                 365             


Asp Asn Leu Asp Lys Lys Glu Lys Asn Glu Val Glu Ile Lys Lys Tyr 
    370                 375                 380                 


Phe Glu Lys Ile Glu Glu Asn Leu Pro Asp Tyr Phe Ile Glu Lys Tyr 
385                 390                 395                 400 


Glu Ser Asn Asn Val Phe Asn Thr Tyr Arg Asn Phe Val Asp Lys Ile 
                405                 410                 415     


Met Glu Val Val Lys Asn Phe Asn Phe Lys Glu Asn Asn Thr Ile Asp 
            420                 425                 430         


Tyr Leu Phe Pro Lys Phe His Lys Ile Tyr Lys Arg Met Cys Lys Ser 
        435                 440                 445             


Glu Asn Ile Asp Asp Arg Gln Asn Gly Ala Arg Lys Tyr Leu Leu Gln 
    450                 455                 460                 


Thr Ile Tyr Tyr Tyr Tyr Phe Gln Tyr Glu Ile Glu Asn Asp Lys Asn 
465                 470                 475                 480 


Asn Met Ser Lys Tyr Leu Asn Leu Tyr Arg Asn Lys Ile Lys Val Lys 
                485                 490                 495     


Lys Ile Ser Tyr Ser Tyr Ile Thr Asp Asn Lys Ala Val Asn Asn Lys 
            500                 505                 510         


Asn Ile Glu Ile Leu Tyr Arg Asn Ile Gln Arg Glu Gly Met Leu Asn 
        515                 520                 525             


Asn Arg Leu Leu Gln Met Asn Asn Glu Trp Ile Glu Phe Ile Val Val 
    530                 535                 540                 


Gln Phe Ser Glu Phe Leu Thr Asn Lys Lys Leu Asn Trp Ile Leu Asp 
545                 550                 555                 560 


Asp Leu Ser Glu Tyr Lys Lys Lys Glu Lys Leu Asp Glu Asn Asp Lys 
                565                 570                 575     


Asn Glu Leu Leu Lys Ile Phe Lys Gln Lys Met Asn Lys Asn Ile Thr 
            580                 585                 590         


Tyr Ser Asn Asp Ser Tyr Val Phe Ile Ser Leu Ala Gln Phe Leu Asp 
        595                 600                 605             


Leu Lys Glu Ile Ser Asn Leu Ile His Asp Ile Lys Lys Phe Ile Gln 
    610                 615                 620                 


Phe Arg Glu Lys Asn Val Ser Lys Tyr Lys Pro Glu Lys Asn Lys Leu 
625                 630                 635                 640 


Tyr Ile Glu Glu Leu Arg Lys Ile Leu Tyr Ile Ser Lys Val Val Leu 
                645                 650                 655     


Glu His Lys Glu Arg Val Met Gln Lys His Tyr Leu Glu Ser Tyr Asp 
            660                 665                 670         


Glu Asp Ile Ser Ile Met Tyr Gly Lys Gly Ile Glu Lys Lys Asp Ile 
        675                 680                 685             


Lys Asp Ile Glu Ile Lys Ile Lys Asn Lys Asn Gln Glu Val Ile Asn 
    690                 695                 700                 


Gln Pro Leu Tyr Lys Ser Gly Asn Asp Glu Asn Asn Ser Trp Ile Ile 
705                 710                 715                 720 


Leu Tyr Gly Ile Glu Gln Ala Lys Arg Asn Gly Ala Phe Lys Phe Phe 
                725                 730                 735     


Glu Gly Phe Phe Asn Leu Asn Asp Asp Ile Lys Leu Cys Lys Glu Asn 
            740                 745                 750         


Ile Glu Lys Tyr Glu Lys Leu Tyr Asn Glu Lys Glu Glu Asn Gln Lys 
        755                 760                 765             


Lys Val Asp Glu Tyr Ile Ser Lys Leu Asn Asn Asp Ile Glu Lys Ile 
    770                 775                 780                 


Asn Asn Asp Asn Asn Asn Ile Asn Ile Glu Lys Thr Asn Asn Asn Lys 
785                 790                 795                 800 


Gln Leu Phe Tyr Tyr Tyr Lys Asn Met Ile Tyr Gly Asp Gly Leu Lys 
                805                 810                 815     


Lys Gly Tyr Asp Phe Ile Asn Asp Ile Tyr Ser His Tyr Leu Ser Trp 
            820                 825                 830         


Ala Tyr Arg Ile Glu Arg Asp Tyr Asp Ile Tyr Lys Val Arg Lys Tyr 
        835                 840                 845             


Ser Glu Ser Ile Lys Arg Phe Arg Asn Glu Ile Ala His Phe Asn Tyr 
    850                 855                 860                 


Phe Gln Lys Thr Asn Lys Ser Leu Leu Glu Leu Leu Asn Asn Phe Tyr 
865                 870                 875                 880 


Asp Ile Phe Asp Tyr Asn Leu Lys Tyr Gln Arg Asp Val Gln Lys Val 
                885                 890                 895     


Ile Asn Asn Ile Phe Glu Lys Tyr Gln Val Ile Arg Glu Asp Gly Gly 
            900                 905                 910         


Pro Val Ile Phe Tyr Cys Lys Ile Asp Lys Lys Leu Lys Leu Ser Glu 
        915                 920                 925             


Asn Ile Ile Pro Lys Lys His Leu Lys Cys Ser Lys Ile Lys Leu Ile 
    930                 935                 940                 


His Glu Lys Tyr Val Glu Phe Phe Lys Lys Leu Phe Glu Tyr Lys Lys 
945                 950                 955                 960 


<210>  1278
<211>  1184
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1278

Met Arg Val Ser Lys Val Lys Val Leu Gly Asn Glu Glu Thr Lys Gly 
1               5                   10                  15      


Arg Ile Val Leu Met His Arg Ser Pro Val Lys Gly Gln Leu Ile Tyr 
            20                  25                  30          


Ser Glu Asp Ala Gly Lys Arg Asp Arg Thr Glu Asp Ile Ile Pro Glu 
        35                  40                  45              


Gln Lys Leu Glu Ser Phe His Leu Ser Ile Leu Asn Lys Thr Phe Leu 
    50                  55                  60                  


Arg Lys Glu Phe Phe Lys Lys Glu Leu Lys His Glu Ala Lys Lys Asn 
65                  70                  75                  80  


Gly Leu Lys Gly Asp Ala Glu Asp Lys Tyr Ile Ser Glu Lys Leu Lys 
                85                  90                  95      


Glu Tyr His Ser Leu Leu Gln Phe Ile Asp Asp Val Leu Ser Val Lys 
            100                 105                 110         


Tyr Asn Glu Asn Arg Lys Ala Ile Lys Phe Pro Glu Tyr Leu Thr Arg 
        115                 120                 125             


Glu Met Ile Glu Ile Phe Leu Asn His Lys Phe Arg Lys Glu Val Thr 
    130                 135                 140                 


Tyr Thr Asn Lys Asn Gly Ala Ser Val Ser Phe Leu Leu Ser Thr Leu 
145                 150                 155                 160 


Ile Leu Asn Ala Ile Glu Lys His Ser Val Ile Glu Met Gln Pro Phe 
                165                 170                 175     


Val Asp Trp Arg Asn Trp Phe Val Glu Thr Lys Ser Lys Phe Leu Lys 
            180                 185                 190         


Lys Ser Ile Ile Asn Asn Cys Ile Pro Thr Asn Gly Gly Pro Ile Ser 
        195                 200                 205             


Arg Arg Arg Glu Thr Leu Met Lys Trp Arg Asp Asp Tyr Phe Thr Asn 
    210                 215                 220                 


Ala Glu Ile Asp Leu Ala Arg Leu His Lys Lys Phe Gly Thr Asp Thr 
225                 230                 235                 240 


Leu Met Ala Ser Leu Arg Glu Val Pro Gln Thr Glu Lys Ser Gly Asn 
                245                 250                 255     


Glu Tyr His Arg Leu Leu Lys Ser Cys Leu Gln Ser His Gln Lys Lys 
            260                 265                 270         


Leu Phe Gly Lys Arg Ala Glu Gly Tyr Asp Ile Asn Arg Ala Asp Asn 
        275                 280                 285             


Gln Leu Tyr Val Tyr Asn Thr Glu Val Val Lys Tyr Met Glu His Tyr 
    290                 295                 300                 


Phe Pro Val Lys Ser Ser Lys Arg Arg Asn Ser Thr Ala Glu Ile Lys 
305                 310                 315                 320 


Tyr Tyr Leu Gln Thr Asp Thr Ile Lys Cys Cys Leu His His Gln Ile 
                325                 330                 335     


Ile Asn Ala Val Arg Gly Leu Ala Leu Arg Glu Gly Lys Phe Asn Leu 
            340                 345                 350         


His Gly Phe Asp Asp Lys Leu Ile Pro Asn Glu Arg Asn Val Ser Ser 
        355                 360                 365             


Ser Ile Leu Asn Glu Leu Lys Thr Ser Glu Gly Phe Val Leu Asn Met 
    370                 375                 380                 


Leu Gly Gly Cys Ala Phe Ala Ala Asn Cys Leu Arg Asn Ile Val Asp 
385                 390                 395                 400 


Ala Thr Gln Arg Ser Asp Leu Leu Gly Phe Arg Cys Phe Glu Val Ser 
                405                 410                 415     


Leu Lys Lys Gly Lys Ser Asn Ser Asp Leu Phe Ala Leu Phe Phe Gly 
            420                 425                 430         


Phe Gly Arg Glu Asp Met Asp Asp Asp Ser Glu Trp Glu Lys His Leu 
        435                 440                 445             


Tyr Ala Ala Arg Tyr Ser Val Ser Glu Ile Arg Asn Arg Val Ala His 
    450                 455                 460                 


Tyr His Lys Ser Ala Ile Glu Asn Ile Tyr Asn Ile Thr Asp Phe Lys 
465                 470                 475                 480 


Tyr Arg Glu Asn Ser Met Cys Ser Tyr Thr Asp Thr Lys Phe Thr Thr 
                485                 490                 495     


Ala Leu Gln Asn Glu Ile Tyr Asn Thr Pro Lys Ala Leu Ser Leu Gln 
            500                 505                 510         


Leu Met Thr Gly Lys Val Leu Glu Tyr Tyr Pro Lys Glu Lys Leu Val 
        515                 520                 525             


Ser Phe Phe Gln Lys Tyr Lys Phe Ser Leu Tyr Arg Ser Val Val Pro 
    530                 535                 540                 


Phe Ala Pro Gly Phe Lys Asn Ile Met Arg Thr Gly Val Asn Tyr Gln 
545                 550                 555                 560 


Asn Ala Thr Gln Asn Arg Leu Phe Tyr Asp Met Gly Leu Thr Ala Phe 
                565                 570                 575     


Gln Asp Lys Asp Arg Tyr Ile Asp Asp Val Glu Ala Trp Asn Ala Arg 
            580                 585                 590         


Tyr Phe Phe Met Lys Leu Ile Tyr Asn Asn Leu Phe Leu Pro Arg Phe 
        595                 600                 605             


Thr Asn Asp Lys Asn Asp Leu Phe Arg Lys Thr Val Glu Gln Val Leu 
    610                 615                 620                 


Glu Val Asn Arg Ser His Met Glu Lys Val Gly Lys Asp Asp Arg Gln 
625                 630                 635                 640 


Ala Phe Gly Glu Val Arg Gln Met Arg Glu Asn Glu Thr Ala Asn Asp 
                645                 650                 655     


Tyr Met Ala Tyr Leu Gln Ser Ser Leu Arg Met Glu Lys Asn Lys Lys 
            660                 665                 670         


Glu Leu Glu Gly Asn Gly Ala Lys Arg Ile Asn Phe Glu Lys Phe Ile 
        675                 680                 685             


Leu Gln Met Phe Val Lys Gly Phe Asp Ser Phe Leu Lys Asp Gly Ala 
    690                 695                 700                 


Phe Glu Phe Val His Ser Pro Glu Asn Cys Leu Thr Gly Ser Thr Glu 
705                 710                 715                 720 


Lys Glu Arg Ala Lys Glu Arg Asn Ser Leu Cys Glu Glu Ile Gly Asn 
                725                 730                 735     


Tyr Val Arg Leu Val Ser Thr Val Ile Asp Pro Gly Lys Gly Ser His 
            740                 745                 750         


Val Ala Phe Tyr Val Phe Cys Lys Met Leu Asn Ser Val Tyr Leu Ser 
        755                 760                 765             


Asn Ile Arg Asn Glu Met Ile Lys Tyr His Lys Val Val Arg Thr Asp 
    770                 775                 780                 


Glu Leu Ala His Leu Ile Glu Ile Ile Glu Leu Cys Leu Leu Ser Ala 
785                 790                 795                 800 


Asp Ala Val Ser Gln Lys Thr Val Asn Ala Asp Lys Leu Ser His Phe 
                805                 810                 815     


Phe Ala Glu Gly Val Asn Val Asp Asp Asp Glu Asn Val Ile His Ala 
            820                 825                 830         


Ser Met Glu Thr Phe Arg Lys Tyr Gly Thr Arg Asp Leu Phe His Lys 
        835                 840                 845             


Leu Met Leu Gln Asp Asp Arg Phe Leu Val Ser Ser Asp Asp Tyr Arg 
    850                 855                 860                 


Glu Trp Glu Glu Met Lys Glu Lys Ile Glu Gly Lys Val Lys Gln Arg 
865                 870                 875                 880 


Glu Leu Leu His Ala Glu Trp Cys Glu Ala Lys Glu Lys Asp Lys Lys 
                885                 890                 895     


Ser Arg Lys Val Lys Ser Asn Ser Arg Thr Cys Phe Glu Lys Lys Phe 
            900                 905                 910         


Met Gly Ala Lys Ala Glu Glu Tyr Tyr Ser Leu Cys Lys Val Ile Asp 
        915                 920                 925             


Lys Tyr Asn Trp Leu Asp Asn Lys Leu His Leu Val His Leu Asn Lys 
    930                 935                 940                 


Leu His Asn Leu Val Ile Glu Ile Leu Gly Arg Met Val Gly Phe Thr 
945                 950                 955                 960 


Ala Leu Phe Glu Arg Asp Phe Gln Tyr Ile Cys Lys Ser Asp Ser Glu 
                965                 970                 975     


Tyr Glu Gln Leu Tyr Asn Leu Asp Phe Asn Met Gly Leu Pro Lys Phe 
            980                 985                 990         


Lys Asn Ser Ile Lys Gly Ser Gly  Lys Ala Lys Asn Ser  Thr Gln Asn 
        995                 1000                 1005             


Ile Asp  His Asn Ala Thr Gly  Ile Gly Asn Ser Ser  Asn Leu Leu 
    1010                 1015                 1020             


Lys Glu  Asn Ser Asn Gly Thr  His Tyr Cys Lys Asn  Leu Ser Gly 
    1025                 1030                 1035             


Asp Gly  Val Glu Asp Lys Leu  Lys Arg Leu Phe Leu  Tyr Asp Asp 
    1040                 1045                 1050             


Tyr Arg  Asn Val Arg Asn Phe  Val Ala His Phe Asn  Tyr Leu Thr 
    1055                 1060                 1065             


Arg Val  Glu Asp Asp Leu Gly  Gly Asn Asp Ala Val  Lys Leu Ser 
    1070                 1075                 1080             


Gly Thr  Arg Tyr Ser Leu Ile  Glu Leu Ile Asn Glu  Leu Arg Asn 
    1085                 1090                 1095             


Leu Leu  Lys Tyr Asp Arg Lys  Leu Lys Asn Ala Val  Ser Lys Ser 
    1100                 1105                 1110             


Phe Ile  Asp Met Phe Glu Arg  His Gly Met His Val  Lys Met Lys 
    1115                 1120                 1125             


Leu Asn  His Asn His Lys Leu  Phe Val Asp Ser Ile  Ser Pro Arg 
    1130                 1135                 1140             


Lys Ile  Lys His Leu Gly Gly  Gly Tyr Lys Lys Arg  Gly Lys Asp 
    1145                 1150                 1155             


Asp Lys  Met Tyr Val Gln Thr  Thr Asn His Val Asp  Pro Leu Tyr 
    1160                 1165                 1170             


Cys Asp  Met Cys Arg Ala Leu  Leu Glu Met Lys 
    1175                 1180                 


<210>  1279
<211>  1100
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1279

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Lys Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  
    1100 


<210>  1280
<211>  1107
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1280

Met Arg Val Ser Lys Val Lys Val Lys Asp Gly Gly Lys Asp Lys Met 
1               5                   10                  15      


Val Leu Val His Arg Lys Thr Thr Gly Ala Gln Leu Val Tyr Ser Gly 
            20                  25                  30          


Gln Ala Ile Ser Asn Glu Thr Asn Asn Ile Leu Pro Glu Lys Lys Arg 
        35                  40                  45              


Gln Ser Phe Asp Leu Ser Ile Glu Asn Lys Thr Leu Lys Arg Arg Asp 
    50                  55                  60                  


Asp Val Asp Lys Thr Lys Lys Asp Lys Tyr Asp Ile Val Arg Lys Ile 
65                  70                  75                  80  


Ile Lys Tyr Gly Glu Leu Pro Gln Ser Ile Ser Glu Val Asp Val Leu 
                85                  90                  95      


Glu Phe Leu Asn His Lys Phe Gln Glu Pro Val Lys Tyr Trp Lys Gly 
            100                 105                 110         


Asp Lys Glu Glu Ser Phe Asn Leu Thr Met Leu Ile Leu Glu Ala Val 
        115                 120                 125             


Lys Thr Gln Asp Lys Gln Lys Leu Gln Pro Tyr Asn Glu Trp Lys Lys 
    130                 135                 140                 


Trp Tyr Val Thr Thr Lys Ser Asp Leu Leu Lys Lys Ser Ile Asp Asn 
145                 150                 155                 160 


Asn Arg Ile Asp Leu Thr Glu Asn Leu Ser Lys Arg Lys Lys Ala Leu 
                165                 170                 175     


Leu Ala Trp Glu Thr Glu Phe Thr Thr Ser Gly Asn Ile Asp Leu Thr 
            180                 185                 190         


His Tyr His Lys Val Tyr Met Thr Asp Val Leu Cys Lys Met Leu Gln 
        195                 200                 205             


Glu Val Lys Pro Leu Thr Asp Glu Arg Gly Arg Ile Asn Ser Asn Ala 
    210                 215                 220                 


Tyr His Arg Gly Leu Lys Lys Ala Leu Gln Asn His Gln Pro Ala Met 
225                 230                 235                 240 


Phe Gly Thr Arg Glu Ala Pro Asn Asp Ala Asn Arg Ala Asp Asn Gln 
                245                 250                 255     


Leu Ser Ile Tyr His Leu Glu Val Val Lys Tyr Leu Glu His Tyr Phe 
            260                 265                 270         


Pro Ile Lys Thr Ser Lys Arg Arg Asn Thr Thr Asp Asp Ile Ser His 
        275                 280                 285             


Tyr Leu Lys Ala Gln Thr Leu Lys Thr Thr Ile Glu Lys Gln Leu Val 
    290                 295                 300                 


Asn Ala Ile Arg Ser Asn Ile Ile Gln Gln Gly Lys Thr Asn His His 
305                 310                 315                 320 


Glu Leu Lys Ala Asp Thr Thr Ser Asn Asp Leu Ile Arg Ile Lys Thr 
                325                 330                 335     


Asn Glu Ala Phe Val Leu Asn Leu Ile Gly Thr Cys Ala Phe Ala Ala 
            340                 345                 350         


Asn Asn Ile Arg Asn Met Val Asp Asn Glu Gln Thr Ser Asp Ile Leu 
        355                 360                 365             


Gly Lys Gly Asp Phe Ser Lys Ser Leu Leu Lys Asp Ser Ala Ser Thr 
    370                 375                 380                 


Gln Leu Tyr Ser Phe Phe Phe Glu Glu Asn Leu Ser Thr Asn Lys Val 
385                 390                 395                 400 


Glu Lys Glu Thr Gln Leu Trp Ala Ile Arg Gly Ala Val Gln Gln Ile 
                405                 410                 415     


Arg Asn Asn Val Asn His Tyr Lys Lys Asp Ala Leu Lys Thr Val Phe 
            420                 425                 430         


Asn Ile Ser Asn Phe Glu Asn Pro Thr Thr Thr Asp Pro Lys Gln Gln 
        435                 440                 445             


Thr Asn Tyr Ala Asp Thr Ile Tyr Lys Ala Arg Phe Ile Asn Glu Leu 
    450                 455                 460                 


Glu Lys Ile Pro Glu Ala Phe Ala Gln Gln Leu Lys Thr Gly Gly Ala 
465                 470                 475                 480 


Leu Ser Tyr Tyr Thr Leu Glu Asn Leu Lys Thr Leu Leu Thr Thr Phe 
                485                 490                 495     


Gln Phe Ser Leu Cys Arg Ser Thr Ile Pro Phe Ala Pro Gly Phe Lys 
            500                 505                 510         


Lys Val Phe Asn Gly Gly Ile Asn Tyr Gln Asn Ala Lys Gln Asp Glu 
        515                 520                 525             


Ser Phe Tyr Glu Leu Met Leu Glu Arg Tyr Leu Arg Lys Glu Asn Phe 
    530                 535                 540                 


Ala Glu Glu Ala Tyr Asn Ala Arg Tyr Phe Leu Leu Lys Leu Ile Tyr 
545                 550                 555                 560 


Asn Asn Leu Phe Leu Pro Lys Phe Thr Thr Tyr Arg Lys Ala Phe Ala 
                565                 570                 575     


Asp Ser Val Gly Phe Val Gln Leu Gln Asn Arg Lys Gln Ala Glu Lys 
            580                 585                 590         


Val Asn Pro Lys Lys Lys Glu Ala Tyr Ala Phe Glu Ala Val Arg Pro 
        595                 600                 605             


Met Thr Ala Ala Asp Ser Ile Ala Asp Tyr Met Ala Tyr Val Gln Ser 
    610                 615                 620                 


Glu Leu Met Gln Glu Gln Asn Lys Lys Glu Glu Lys Ala Thr Asp Glu 
625                 630                 635                 640 


Thr Arg Ile Asn Phe Glu Lys Phe Val Leu Gln Val Phe Ile Lys Gly 
                645                 650                 655     


Phe Asp Ser Phe Leu Arg Ala Lys Glu Phe Asp Phe Val Gln Val Pro 
            660                 665                 670         


Gln Gln Gln Leu Thr Thr Thr Asp Ser Asn Gln Gln Lys Ala Asp Lys 
        675                 680                 685             


Leu Asn Gly Leu Glu Ala Ser Ile Thr Ala Asp Cys Lys Leu Thr Pro 
    690                 695                 700                 


Gln Tyr Ala Lys Ala Asp Asp Ala Thr His Ile Ala Phe Tyr Val Phe 
705                 710                 715                 720 


Cys Lys Leu Leu Asp Ala Ala His Leu Ser Asn Leu Arg Asn Glu Leu 
                725                 730                 735     


Ile Lys Phe Arg Gly Ser Val Asn Glu Phe Lys Phe His His Leu Leu 
            740                 745                 750         


Glu Ile Ile Glu Ile Cys Leu Leu Ser Ala Asp Val Val Pro Thr Asp 
        755                 760                 765             


Tyr Arg Asp Leu Tyr Thr Asn Glu Ala Asp Cys Leu Ala Arg Leu Ser 
    770                 775                 780                 


Pro Phe Ile Glu Gln Gly Ala Asp Ile Lys Asn Trp Ser Asp Leu Tyr 
785                 790                 795                 800 


Val Gln Thr Asp Lys Gln Thr Pro Val Val His Ala Gly Ile Glu Leu 
                805                 810                 815     


Ser Val Lys Tyr Gly Thr Thr Ala Leu Leu Glu Gln Leu Ile Ala Arg 
            820                 825                 830         


Asn Pro Lys Phe Arg Ile Met Glu Asp Asn Phe Thr Lys Trp Ser Asn 
        835                 840                 845             


Gln Lys Lys Glu Ile Glu Glu Lys Val Asn Ile His Thr Lys Leu His 
    850                 855                 860                 


Lys Glu Trp Val Glu Ala Lys Glu Lys Asp Asp Lys Glu Arg Thr Asp 
865                 870                 875                 880 


Arg Val Lys Ser Lys Thr Asn Phe Ala Arg Lys Phe Val Ser Lys Asn 
                885                 890                 895     


Glu Val Asp Tyr Ile Asn Asn Cys Ile Glu Ile Asn Asn Tyr Asn Trp 
            900                 905                 910         


Leu Asp Asn Lys Leu His Phe Val His Leu Asn His Leu His His Leu 
        915                 920                 925             


Thr Ile Glu Ile Leu Gly Arg Met Ala Gly Phe Val Ala Leu Trp Glu 
    930                 935                 940                 


Arg Asp Phe Gln Tyr Ile Thr Lys Tyr Thr Ala Ala Lys Glu Gly Thr 
945                 950                 955                 960 


Asp Ala Leu Ser Phe Asp Gly Gly Leu Pro Arg Leu Lys Asp Lys Gln 
                965                 970                 975     


Lys Tyr Tyr Asp Lys Leu Phe Leu Ser Asp Lys Tyr Thr Lys Val Arg 
            980                 985                 990         


Asn His Ile Ala His Phe Asn Tyr  Leu Thr Lys Asp Ala  Ala Asp Phe 
        995                 1000                 1005             


Ser Leu  Ile Asp Leu Ile Asn  Glu Leu Arg Glu Leu  Leu His Tyr 
    1010                 1015                 1020             


Asp Arg  Lys Leu Lys Asn Ala  Val Ser Lys Ala Phe  Ile Lys Leu 
    1025                 1030                 1035             


Phe Glu  Lys His Gly Met Ile  Leu Lys Leu Lys Leu  Asn Asp Gly 
    1040                 1045                 1050             


His Gln  Leu Glu Leu Glu Ser  Ile Glu Pro Lys Lys  Ile Tyr His 
    1055                 1060                 1065             


Leu Gly  Ser Ser Ala Lys Asp  Lys Pro Glu Tyr Gln  Tyr Cys Thr 
    1070                 1075                 1080             


Asn Gln  Val Met Thr Ala Tyr  Cys Asn Met Cys Arg  Ser Leu Leu 
    1085                 1090                 1095             


Glu Met  Lys Lys Glu Gln Ile  Gly Leu 
    1100                 1105         


<210>  1281
<211>  1387
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1281

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Glu Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro Ile Tyr Ser Lys Gln Gln Gly Glu Pro Glu 
            900                 905                 910         


Tyr Leu Asp Thr Leu Glu Leu Glu Ser Gly Val Lys Glu Lys Asn Tyr 
        915                 920                 925             


Glu Trp Phe Thr Leu Ala His Phe Leu His Pro Val Gln Leu Asn His 
    930                 935                 940                 


Leu Val Gly Asp Leu Lys Ser Tyr Ile Gln Tyr Arg Glu Asp Ile Leu 
945                 950                 955                 960 


Arg Arg Ile Val Phe Ala Glu Gln Arg Val Tyr Ala Asp Gln Gln Lys 
                965                 970                 975     


Glu Val Gln Gln Lys Val Lys Thr Ala Lys Glu Ile Leu Glu Val Leu 
            980                 985                 990         


Glu Phe Val Arg Glu Val Ser Gly  Arg Val Ser Asn Glu  Tyr Thr Asp 
        995                 1000                 1005             


Tyr Tyr  Glu Asn Glu Glu Glu  Tyr Ala Glu Phe Leu  Tyr Gln Tyr 
    1010                 1015                 1020             


Ile Asp  Phe Arg Lys Arg Glu  Gly Lys Ser Ala Phe  Glu Ser Leu 
    1025                 1030                 1035             


Lys Tyr  Phe Cys Gln Asn Ile  Leu Asp Ser Gly Thr  Val Val Asp 
    1040                 1045                 1050             


Leu Tyr  Ala Asp Thr Glu Asn  Pro Lys Val Leu Arg  Asn Ile Glu 
    1055                 1060                 1065             


Leu Thr  Arg Met Tyr Ala Gly  Ser Asn Val Lys Ile  Pro Glu Tyr 
    1070                 1075                 1080             


Glu Lys  Ile Thr Glu Asp Glu  Ile Lys Met Tyr Tyr  Gln Glu Lys 
    1085                 1090                 1095             


Asn Ser  Val Ala Leu Ile Leu  Ser Arg Gly Leu Cys  Arg Asn Glu 
    1100                 1105                 1110             


Lys Glu  Gln Lys Lys Val Ile  Glu Phe Asn Trp Lys  Lys Lys Arg 
    1115                 1120                 1125             


Leu Thr  Leu Asn Glu Ile Thr  Asp Val Phe Ser Leu  Val Asn Asp 
    1130                 1135                 1140             


Leu Leu  Gly Lys Met Ile Ser  Phe Ser Tyr Leu Arg  Glu Arg Asp 
    1145                 1150                 1155             


Gln Met  Tyr Leu Leu Leu Gly  Phe Tyr Tyr Met Ala  Leu Cys Ala 
    1160                 1165                 1170             


Glu Asn  Lys Ser Glu Asn His  Leu Gly Trp Lys Gly  Glu Thr Leu 
    1175                 1180                 1185             


Asp Lys  Leu Glu Ser Ser Asp  Ser Lys Phe Asp Ile  Gly Gly Gly 
    1190                 1195                 1200             


Leu Val  Leu Tyr Gln Ile Val  Ser Ala Phe Asn Phe  Gly Ser Lys 
    1205                 1210                 1215             


Leu Leu  Tyr Ile Ser Glu Asp  Gly Arg Trp Lys Met  Ala Gly Gly 
    1220                 1225                 1230             


Ala Phe  Pro Gly Lys Tyr Gly  Arg Phe Glu Asn Asp  Tyr Asn His 
    1235                 1240                 1245             


Arg Thr  Ser Leu Ser Lys Val  Ile Arg Leu Phe Glu  Asn Glu Ser 
    1250                 1255                 1260             


Tyr Glu  Arg Glu Ile Ile Tyr  Trp Arg Asp Tyr Val  Asp His Met 
    1265                 1270                 1275             


Lys Tyr  Tyr Val Asn Gln Asn  Gln Ser Ile Met Glu  Ile Tyr Ser 
    1280                 1285                 1290             


Ala Phe  Tyr Ser Lys Val Leu  Gly Tyr Ser Ala Lys  Leu Arg Lys 
    1295                 1300                 1305             


Ser Val  Val Phe Asn Leu Gln  Ala Ala Leu Glu Lys  His His Ile 
    1310                 1315                 1320             


Asn Pro  Glu Cys Ile Trp Met  Thr Ser Asp Gly Lys  Cys Ala Asp 
    1325                 1330                 1335             


Ile Lys  Leu Met Lys Asn Leu  Glu Ser Gln Lys Phe  Thr Tyr Lys 
    1340                 1345                 1350             


Leu Ala  Lys Arg Glu Gly Glu  Lys Thr Glu Arg Lys  Ile Cys Met 
    1355                 1360                 1365             


Asn Ala  Leu Asn Glu Asn Phe  Leu Lys Thr Ile Arg  Thr Ser Leu 
    1370                 1375                 1380             


Glu Tyr  Lys Lys 
    1385         


<210>  1282
<211>  949
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1282

Met Arg Ile Val Arg Pro Tyr Gly Glu Ser Val Ala Pro Gly Ala Gly 
1               5                   10                  15      


Ser Glu Arg Leu Leu Arg Pro Lys Lys Gln Leu Arg Asp Gln Ile Gly 
            20                  25                  30          


Asp Ala Asp Arg Arg Ile Pro Thr Phe Ala Ala Gly His Asp Glu Leu 
        35                  40                  45              


Val Ile Ala Gln Trp Ile Ser Thr Ile Asp Lys Ile Ala Thr Lys Pro 
    50                  55                  60                  


Lys Gly Asn Lys Glu Pro Thr Pro Arg Gln Arg Ala Leu Arg Glu Lys 
65                  70                  75                  80  


Leu Gly Lys Ala Gly Trp Asp Arg Leu Val Asp Gln Lys Leu Leu Pro 
                85                  90                  95      


Gly Leu Pro Lys Asp Gln Asp Asp Tyr Leu Gly Lys Leu Trp Trp Phe 
            100                 105                 110         


Lys Ile His Pro Tyr Pro Lys Gly Thr Lys Ala Pro Lys Val Val Asn 
        115                 120                 125             


Gly Arg Glu Ile Pro Asp Pro Arg Gly Arg Trp Tyr Ser Arg Phe Val 
    130                 135                 140                 


Cys Asp Val Ala Pro Asp Asp Ile Asp Ala Ala Thr Val Ala Ala Arg 
145                 150                 155                 160 


Val His Glu His Leu His Val Ala Glu Tyr Arg His Gly Thr Glu Gln 
                165                 170                 175     


Lys His Asp Lys Gly Arg Ile Glu Arg Arg Ala Arg Ser Ile Ala Lys 
            180                 185                 190         


Asn Thr Ala Ser Leu Ala Gln Val Thr Lys Glu Arg Pro Thr Trp Thr 
        195                 200                 205             


Glu Asp Asp Val Ala Thr Tyr Ala Gln Thr Ala Gly Asp Val Ala Thr 
    210                 215                 220                 


Ala Ile Lys Gln Ala Ala Glu Ala Arg Glu Ala Asp Asn Arg Arg Val 
225                 230                 235                 240 


Gly Ala Asp Val Ala Ala Glu Val Leu Tyr Pro Ala Phe Gly Lys Leu 
                245                 250                 255     


Phe Pro Asn Lys Gly Ile Lys Glu Leu Glu Asn Gln Ser Gly Leu Pro 
            260                 265                 270         


Ala Leu His Leu Ala Ile Arg Asp Phe Tyr Gln Arg Arg Leu Lys Arg 
        275                 280                 285             


His Lys Lys Asp Gln Pro Glu His Lys Met Ala Arg Arg Lys Val Ser 
    290                 295                 300                 


Thr Leu Leu Pro Ala Asp Met Ala Gly Leu Ala Ala Met Leu Arg His 
305                 310                 315                 320 


Thr Ala Ala Asn Arg Asp Val Ala Ala Leu Val Arg Leu Gly Lys Val 
                325                 330                 335     


Ile His Tyr Glu Ala Ala Phe Ala Ala Gly Gln Lys Ala Ala Asp Gly 
            340                 345                 350         


Asp Ala Pro Ala His Val Leu Glu Lys Trp Pro Ala Glu Val Lys Ala 
        355                 360                 365             


Ser His Tyr Trp Ser Ser Glu Gly Gln Ala Glu Ile Lys Arg Asn Glu 
    370                 375                 380                 


Ala Phe Val Arg Ile Trp Arg His Ser Leu Ala Leu Ala Ala Gln Thr 
385                 390                 395                 400 


Leu Arg Asp Trp Ala Ser Pro Asp Gly Ser Phe His Thr Asp Ile Leu 
                405                 410                 415     


Ser Glu Lys Gln Phe Glu Thr Leu Thr Lys Asn Leu Asp Leu Asp His 
            420                 425                 430         


His Ala Arg Lys Leu Ala Val Leu Leu Gly Asn Arg Ala Glu Phe Phe 
        435                 440                 445             


Leu Lys Gly Arg Gly Asp Ala Phe Gln Lys Gln Thr Leu Lys Leu Ala 
    450                 455                 460                 


Leu Gln Gly Leu Thr Gln Leu Arg His Asn Ser Phe His Phe Asn Gly 
465                 470                 475                 480 


Arg Gly Gly Phe Ala Asp Ala Leu Lys Phe Thr Arg Lys Pro Glu Ile 
                485                 490                 495     


Thr Ala Asp Gln His Met Trp Asp Ala Leu Gly Ala Leu Trp Ala Thr 
            500                 505                 510         


Asp Leu Glu Glu Arg Gly Lys Arg Leu Ile Asp Thr Leu Glu Ala Ala 
        515                 520                 525             


His Leu His His Phe Phe Asp Trp Glu His Asn Lys Arg Leu Ile Gly 
    530                 535                 540                 


Ala Val Ala Arg Ala Lys Leu Ala Glu Gly Ala Glu Asp Leu Pro Leu 
545                 550                 555                 560 


Pro Arg Phe Arg Arg Leu Leu Asp Arg Ala Ala Asn Ile Arg Gly Lys 
                565                 570                 575     


Asp Gly Ile Asn Leu Arg Leu Pro Lys Pro Val Asn Arg Gln Asp Met 
            580                 585                 590         


Glu Asp Phe Pro Ala Leu His Ala Lys Tyr Val Ala Leu Lys Leu Leu 
        595                 600                 605             


Tyr Glu Asn Pro Phe Arg Gln Trp Val Gly His Arg Asp Arg Arg Asp 
    610                 615                 620                 


Leu Val Asn Lys Leu Ile Asp Arg Ala Val Arg Arg Ala Asp Lys Ala 
625                 630                 635                 640 


Ala Lys Asp Leu His Gly Lys Ala Asp Ala Asp Arg Arg Leu Ile Ile 
                645                 650                 655     


Thr Ala Lys Ala Lys Gly Leu Gly Arg Leu Gly Glu Gly Glu Lys Leu 
            660                 665                 670         


His Asp Phe Ala Phe Arg Leu Ser Arg Glu Thr Ala Ser Glu Met Arg 
        675                 680                 685             


Val Gln Arg Gly Tyr Asp Ser Asp Gly Glu Arg Ala Arg Glu Gln Ala 
    690                 695                 700                 


Ala Phe Ile Glu Glu Leu Leu Ile Asp Val Leu Ala Gln Ala Phe Asp 
705                 710                 715                 720 


His Tyr Leu Arg Lys Lys Lys Phe Asp Phe Leu Val Asp Leu Arg Ala 
                725                 730                 735     


Asp Glu Pro Arg Pro Lys Glu Pro Lys Cys Ala Leu Arg Arg Pro Val 
            740                 745                 750         


Leu Asp Ala Glu Gly Ala Ala Ala Pro Gln Trp Gln Val Leu Leu Tyr 
        755                 760                 765             


Phe Leu Leu His Leu Ile Pro Val Asp Asp Ile Gly Arg Leu Val His 
    770                 775                 780                 


Gln Ile Arg Lys Trp Asp Ile Thr Ala Gly Lys Ala Ala Gly Thr Thr 
785                 790                 795                 800 


Arg Ala Ala Asp Asp Asp Val Asp Arg Val Ala Arg Thr Leu Thr Leu 
                805                 810                 815     


Tyr Leu Asp Met His Asp Ala Lys Phe Thr Gly Asp Gln Ala Leu Gln 
            820                 825                 830         


Ala Leu Ala Pro Leu His Glu Leu Tyr Ala Ser Lys Glu Thr Phe Glu 
        835                 840                 845             


Arg Phe Phe Leu Arg Lys Ala Thr Asp Asp Asn Glu Tyr Leu Pro Arg 
    850                 855                 860                 


Arg Gly Leu Arg Glu Ile Leu Arg Phe Gly His Leu Pro Pro Leu Arg 
865                 870                 875                 880 


Ala Ile Phe Ala Ala His Lys Val Asp Asp Asp Thr Val Gln Lys Val 
                885                 890                 895     


Glu Ala Ala Glu Lys Gly Pro Leu Val Ala Ala Gln Arg Glu Arg Glu 
            900                 905                 910         


Arg Leu His Lys Leu Trp Val Asp Gln Arg Arg Lys Leu Gly Ala Glu 
        915                 920                 925             


Asp Leu Arg Cys Tyr Val Asp Thr Leu Ala Glu Val Thr Arg His Arg 
    930                 935                 940                 


His Ala Ala Ala His 
945                 


<210>  1283
<211>  1239
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1283

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Ser Ile Arg Asn Pro Lys Glu Lys Lys Glu Gln Arg Val 
            100                 105                 110         


Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser Ile Lys 
        115                 120                 125             


Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val Lys Phe 
    130                 135                 140                 


Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr Gly Ser 
145                 150                 155                 160 


Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu Arg Lys 
                165                 170                 175     


Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly Tyr Arg 
            180                 185                 190         


Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile Cys Leu 
        195                 200                 205             


Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala Phe Phe 
    210                 215                 220                 


Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu Gln Ile 
225                 230                 235                 240 


Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val Glu Lys 
                245                 250                 255     


Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg Lys Lys 
            260                 265                 270         


Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp Glu Lys 
        275                 280                 285             


Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly Leu Tyr 
    290                 295                 300                 


Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe Ser Asp 
305                 310                 315                 320 


Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
                325                 330                 335     


Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys Glu Asn 
            340                 345                 350         


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        355                 360                 365             


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    370                 375                 380                 


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
385                 390                 395                 400 


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                405                 410                 415     


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            420                 425                 430         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        435                 440                 445             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    450                 455                 460                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
465                 470                 475                 480 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                485                 490                 495     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            500                 505                 510         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        515                 520                 525             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    530                 535                 540                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
545                 550                 555                 560 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                565                 570                 575     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            580                 585                 590         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        595                 600                 605             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    610                 615                 620                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
625                 630                 635                 640 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                645                 650                 655     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            660                 665                 670         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        675                 680                 685             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    690                 695                 700                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
705                 710                 715                 720 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                725                 730                 735     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            740                 745                 750         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        755                 760                 765             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    770                 775                 780                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
785                 790                 795                 800 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                805                 810                 815     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            820                 825                 830         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        835                 840                 845             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    850                 855                 860                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
865                 870                 875                 880 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                885                 890                 895     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            900                 905                 910         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        915                 920                 925             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    930                 935                 940                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
945                 950                 955                 960 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                965                 970                 975     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            980                 985                 990         


Leu Tyr Ser Phe Cys Lys Gln Lys  Phe Lys Val Asp Gly  Lys Glu Tyr 
        995                 1000                 1005             


Met Ala  Gly Ile Tyr Tyr Asp  Gly Glu Asn Leu Ile  Pro Asn Arg 
    1010                 1015                 1020             


Asn Ile  Ile Arg Ala Asn Met  Tyr Gly Asn Thr Ser  Cys Leu Lys 
    1025                 1030                 1035             


Pro Cys  Met Asp Arg Ile Thr  Leu Lys Glu Ile Arg  Thr Met Tyr 
    1040                 1045                 1050             


Ala Asp  Gln Asn Lys Leu Asp  Leu Val Leu Lys Glu  Gly Val Cys 
    1055                 1060                 1065             


His Thr  Glu Glu Glu Gln Lys  Ala Tyr Arg Glu Tyr  Gln Asn Glu 
    1070                 1075                 1080             


Lys Asn  Arg Ile Glu Leu Phe  Asp Val Cys Thr Tyr  Thr Gln Ile 
    1085                 1090                 1095             


Leu Asn  Asp Met Gln Ala Arg  Leu Ile Gly Trp Ser  Tyr Met Arg 
    1100                 1105                 1110             


Glu Arg  Asp Leu Met Tyr Tyr  Gln Leu Gly Tyr Tyr  Tyr Thr Lys 
    1115                 1120                 1125             


Leu Phe  Trp Thr Asp Ser Ile  Ser Glu Glu Asp Ala  Arg Arg Arg 
    1130                 1135                 1140             


Leu Val  Gly Asn Leu Val Asn  Val Glu Asp Gly Ala  Ile Leu Tyr 
    1145                 1150                 1155             


Gln Ile  Leu Ala Phe Asn Ser  Tyr Asn Leu Pro Ile  Ile Ala Asn 
    1160                 1165                 1170             


Lys Asn  Asn Thr Val Thr Leu  Leu Lys Asp Glu Gly  Ser Ile Gly 
    1175                 1180                 1185             


Gly Lys  Ala Ile Thr Ala Phe  Phe Lys Asn Tyr Glu  Asn Ala Glu 
    1190                 1195                 1200             


Met Ile  Tyr Glu Glu Ala Leu  Asp Leu Phe Glu Asn  Met Asp Glu 
    1205                 1210                 1215             


His Ala  Ala Ile Ile Asn Thr  Arg Asn Tyr Ile Glu  His Phe Lys 
    1220                 1225                 1230             


Tyr Phe  Ile Lys Ser Asp 
    1235                 


<210>  1284
<211>  1212
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1284

Met Lys Ile Ser Lys Glu Gly His Lys Arg Met Ser Val Thr Leu Lys 
1               5                   10                  15      


Lys Glu Asn Met Gln Lys Asn Asp Ala Asp Lys Thr Lys Gly Gln Ile 
            20                  25                  30          


Leu Pro Leu Pro Glu Gly Glu Gly Leu Glu Lys Tyr Ile Gln Lys Arg 
        35                  40                  45              


Val Ala Asn Thr Gln Lys Leu Tyr Lys Val Leu Gly Pro Ser Ala Val 
    50                  55                  60                  


Ser Val Pro Asn Glu Lys Glu Lys Glu Thr Ile Asp Cys Phe Asn Asp 
65                  70                  75                  80  


Phe Ile Lys Asn Ile Ile Leu Lys Asn Val Asn Thr Gln Pro Ala Glu 
                85                  90                  95      


Lys Arg Asn Arg Asn Ala Val Glu Tyr Met Lys Thr Lys Gly Asn Val 
            100                 105                 110         


Asn Thr Val Phe Ile Asp Val Asp Arg Lys Cys Ile His Lys Leu Val 
        115                 120                 125             


Pro Leu His Leu Arg Gly Thr Leu Lys Lys Tyr Val Lys Ile Glu Lys 
    130                 135                 140                 


Asp Gly Gln Arg Ile Glu Val Tyr Ile Pro Asp Val Ile Glu Lys Leu 
145                 150                 155                 160 


Val Phe Ala Val Ala His Gly Thr Gln Phe Asp His Leu Ile Ala Glu 
                165                 170                 175     


Ile Glu Glu Glu Glu Leu Ile Val Cys Leu His Met Ile Phe Lys Asp 
            180                 185                 190         


Tyr Thr Lys Glu Asp Ile Ile Ala Asn Thr Ala Lys Ser Ile Glu Lys 
        195                 200                 205             


Gln Asp Val Lys Val Gln Val Leu Gly Thr Gly Glu Asp Ala Arg Leu 
    210                 215                 220                 


Gln Leu Ala Ser Ala Asp Asn Glu Lys Lys Lys Tyr Ile Phe Leu Phe 
225                 230                 235                 240 


Leu Lys Lys Phe Ala Cys Ala Val Ser Glu Lys Glu Arg Asn Asp Leu 
                245                 250                 255     


Leu Arg Glu Phe Arg Glu Leu Leu Val Leu Phe Tyr Cys Gly Thr Ala 
            260                 265                 270         


Ala Tyr Glu Glu Val Lys Glu Trp Lys Asn Gly Ile Pro Ile Trp Asp 
        275                 280                 285             


Phe Asp Phe Leu Ser Lys Met Val Ser Asp Ile Ser Trp Phe Phe Ser 
    290                 295                 300                 


Gln Glu Cys Ser Glu Lys Leu Met Glu Arg Glu Gln Leu Arg Arg Glu 
305                 310                 315                 320 


Lys Asp Lys Asp Lys Lys Arg Gln Asn Lys Ser Lys Ile Lys Asp Ile 
                325                 330                 335     


Asp Val Glu Val Lys Gly Ile Leu Ala Asn Leu Ile Thr Glu Arg Tyr 
            340                 345                 350         


Arg Glu Ser Ile Lys Leu Leu Gln Ser Leu Leu Gly Glu Glu Glu Tyr 
        355                 360                 365             


Lys Glu Lys Cys Phe Trp Leu Glu Tyr Ile Glu Asn Asp Ala Glu Lys 
    370                 375                 380                 


Ile Leu Cys Ser Lys Lys Thr Leu Thr Glu Asn Lys Leu Asp Thr Val 
385                 390                 395                 400 


Trp Leu Cys Asn Asn Thr Trp Arg Asn Phe Leu Ser Phe Leu Cys Ser 
                405                 410                 415     


Lys Ala Val Asp Met Gly Lys Ala Val Tyr His Phe Ala Met Pro Asp 
            420                 425                 430         


Leu Glu Gln Leu Glu Ser Gly Glu Pro Ile Lys Ala Gly Met Ile Lys 
        435                 440                 445             


Ser Gln Phe Gln Gln Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys 
    450                 455                 460                 


Ala Glu Glu Asn Leu Glu Arg Ser Phe Met Thr Ala Ile Ser Phe Ala 
465                 470                 475                 480 


Leu Asn Asn Phe Ser Ala Ala Val Cys Pro Pro Glu Thr Tyr Glu Lys 
                485                 490                 495     


Lys Asn Lys Glu Asp Val Leu Phe Met Gly Asp Lys Asp Leu Arg Glu 
            500                 505                 510         


Glu Met Tyr Pro Asn Ala Ser Trp His Ile Met Gln Tyr Phe Gly Gly 
        515                 520                 525             


Ile Ser Gln Trp Lys Asp Ser Cys Phe Glu Asp Ile Val Met Leu Glu 
    530                 535                 540                 


Asp Ala Asp Leu Asn Glu Glu Phe Val Leu Glu Val Lys Gly Ala Met 
545                 550                 555                 560 


Ser Leu Ile Arg Asn Ser Ala Phe His Tyr Ala Ala Ser Ala Ala Gln 
                565                 570                 575     


Gly Thr Leu Asp Lys Gly Ser Tyr Leu Val Glu Leu Phe Glu Arg Glu 
            580                 585                 590         


Arg Asp Asn Leu Gly Ser Lys Tyr Arg Lys Lys Tyr Val Ser Asn Asn 
        595                 600                 605             


Val Pro Met Phe Tyr Lys Val Glu Asp Ile Asp Arg Leu Met His Cys 
    610                 615                 620                 


Leu Tyr Gly Glu Gln Lys Val Leu Glu Ser Gln Ile Pro Ser Phe Arg 
625                 630                 635                 640 


Asn Val Ile Thr Arg Lys Ser Leu Pro Asp Ile Ile Val Lys Phe Val 
                645                 650                 655     


Lys Gly Lys Pro Tyr Gly Lys Ile Gln Lys Asn Val Glu Thr Ala Ser 
            660                 665                 670         


Lys Phe His Ser Ala Leu Tyr Phe Val Leu Lys Glu Ile Tyr Tyr Asn 
        675                 680                 685             


Gly Phe Leu Gln Glu Glu Asn Leu Met Glu Arg Phe Met Val Ser Phe 
    690                 695                 700                 


Asn Asn Glu Trp Asn Lys Val Lys Glu Ser Ser Gly Asn Lys Lys Lys 
705                 710                 715                 720 


Glu Ala Ala Met Lys Asp Phe Ser Arg Arg Ile Asn Glu Leu Gln Gln 
                725                 730                 735     


Asn Gly Lys Arg Leu Thr Phe Gly Glu Leu Cys Gln Ala Ile Met Thr 
            740                 745                 750         


Asp Tyr Asn Met Gln Asn Asn Gln Lys Lys Val Arg Leu Asn Lys Lys 
        755                 760                 765             


Asp Asn Leu Pro Asp Glu Lys Tyr Lys His Phe Lys Met Leu Leu Leu 
    770                 775                 780                 


Val Cys Leu Arg Glu Thr Phe Ile Asp Tyr Leu Lys Lys Asp Val Ala 
785                 790                 795                 800 


Gly Glu Lys Phe Asp Cys Ala Phe Leu Arg Glu Pro Gly Leu Lys Glu 
                805                 810                 815     


Asn Val Tyr Glu Asn Leu Thr Glu Glu Gln Phe Cys Lys Gly Trp Lys 
            820                 825                 830         


Ile Asp Arg Tyr Lys Asn Leu Ile Asn Glu Asn Gly Gln Tyr Asp Ser 
        835                 840                 845             


Trp Leu Ile Ser Trp Phe Ile Leu Ala His Phe Met Thr Pro Lys His 
    850                 855                 860                 


Leu Asn His Leu Cys Gly Glu Ile Lys Ser Tyr Leu Ser Tyr Val His 
865                 870                 875                 880 


Asn Ile Glu Arg Arg Arg Phe Asp Ala Met Arg Val Gln Val Glu Glu 
                885                 890                 895     


Asn Lys Glu Lys Arg Gln Lys Tyr Glu Gln Val Leu Glu Ile Leu Asn 
            900                 905                 910         


Leu Ala Ala Glu Tyr Cys Gly Gln Val Ser Asn Glu Arg Thr Asp Tyr 
        915                 920                 925             


Tyr Glu Ser Glu Glu Glu Tyr Ala Arg His Ile Ser Met Tyr Val Ala 
    930                 935                 940                 


Phe Glu Glu Lys Asn Ser Glu Arg Pro Leu Glu Glu Gln Leu Tyr Gly 
945                 950                 955                 960 


Phe Cys Asn Gln Lys Ala Asp Gly Gly Pro Ala Ser Arg Ile Gly Ile 
                965                 970                 975     


Phe Tyr Asp Gly Glu Asn Pro Ile Leu Asn Arg Asn Val Val Leu Thr 
            980                 985                 990         


Lys Leu Tyr Gly Ala Glu Arg Leu  Leu Ser Glu Cys Leu  Gln Lys Glu 
        995                 1000                 1005             


Arg Val  Thr Lys Ala Glu Ile  Glu Lys His Tyr Lys  His Thr Lys 
    1010                 1015                 1020             


Lys Leu  Glu Ala Val Phe Lys  Tyr Gly Thr Cys Lys  Asn Gln Asp 
    1025                 1030                 1035             


Gln Glu  Lys Glu Arg Arg Thr  Tyr Gln Gln Gln Lys  Asn Arg Ile 
    1040                 1045                 1050             


Glu Leu  Val Asp Ile Leu Lys  Tyr Ser Asp Leu Leu  Asn Asp Phe 
    1055                 1060                 1065             


Met Ser  Gln Leu Ile Ser Trp  Cys Tyr Leu Arg Glu  Arg Asp Arg 
    1070                 1075                 1080             


Met Tyr  Phe Gln Ile Gly Leu  His Tyr Ile Arg Leu  Tyr Tyr Gly 
    1085                 1090                 1095             


Glu Asn  Leu Val Glu Lys Asn  Ser Lys Phe Arg Val  Leu Gln Ser 
    1100                 1105                 1110             


Lys Glu  Ala Gln Ala Gly Glu  Lys Lys Gly Ile Asn  Leu Val Asp 
    1115                 1120                 1125             


Gly Ala  Val Leu Tyr Gln Ile  Ala Ala Ile Tyr Thr  Tyr Glu Tyr 
    1130                 1135                 1140             


Pro Val  Tyr Thr Leu Asp Glu  Ala Gly Asn Ala Ile  Val Ser Lys 
    1145                 1150                 1155             


Ala Ala  Lys Ile Gly Ser Thr  Thr Ala Asn Gly Ile  Asn Ala Phe 
    1160                 1165                 1170             


Trp Lys  Glu Tyr Cys Asn Glu  Asp Ala Ser Ile Tyr  Glu Val Gly 
    1175                 1180                 1185             


Leu Ser  Leu Phe Glu Asn Pro  Leu Glu Glu Lys Glu  Leu Ile Glu 
    1190                 1195                 1200             


Phe Arg  Asn Tyr Ile Asp His  Phe Lys 
    1205                 1210         


<210>  1285
<211>  1082
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1285

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu Tyr Leu Lys Asp Ser Ile Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Asn Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asp Ala Tyr Val Ser 
            180                 185                 190         


Asn Val Lys Glu Ala Phe Asp Lys Leu Tyr Lys Glu Glu Asp Ile Ala 
        195                 200                 205             


Lys Leu Val Leu Lys Ile Glu Asn Leu Thr Lys Leu Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Phe Tyr His Glu Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Lys Asp Asp Ile Thr Gly Lys Met Arg Gly Lys Thr Arg Ile Asp Ser 
                405                 410                 415     


Lys Thr Gly Glu Glu Lys Tyr Ile Pro Gly Glu Val Asp Gln Ile Tyr 
            420                 425                 430         


Tyr Glu Asn Lys Gln Asn Glu Val Lys Asn Lys Leu Lys Met Phe Tyr 
        435                 440                 445             


Gly Tyr Asp Phe Asp Met Asp Asn Lys Lys Glu Ile Glu Asp Phe Phe 
    450                 455                 460                 


Ala Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His 
465                 470                 475                 480 


Phe Asn Leu Asp Leu Asp Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile 
                485                 490                 495     


Val Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu 
            500                 505                 510         


Lys Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val 
        515                 520                 525             


Phe Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr 
    530                 535                 540                 


Arg Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr 
545                 550                 555                 560 


Lys Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr 
                565                 570                 575     


Trp Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Thr 
            580                 585                 590         


Asp Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu 
        595                 600                 605             


Asn Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ile Lys Glu 
    610                 615                 620                 


Ile Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe 
625                 630                 635                 640 


Tyr Lys Leu Gln Lys Phe Glu Asn Leu Gln Glu Lys Thr Pro Lys Glu 
                645                 650                 655     


Tyr Leu Ala Asn Ile Gln Ser Phe Tyr Met Ile Asp Ala Gly Asn Lys 
            660                 665                 670         


Asp Glu Glu Glu Lys Asp Ala Tyr Ile Asp Phe Ile Gln Lys Ile Phe 
        675                 680                 685             


Leu Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu 
    690                 695                 700                 


Ile Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys 
705                 710                 715                 720 


Lys Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn 
                725                 730                 735     


Ile Lys Ile Pro Tyr Glu Ile Asn Glu Phe Leu Arg Glu Ile Lys Leu 
            740                 745                 750         


Gly Asn Ile Leu Lys Tyr Thr Glu Arg Leu Asn Met Phe Tyr Leu Ile 
        755                 760                 765             


Leu Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu 
    770                 775                 780                 


Glu Lys Tyr Gln Ser Ala Asn Lys Glu Glu Thr Phe Ser Asp Glu Leu 
785                 790                 795                 800 


Glu Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp 
                805                 810                 815     


Phe Glu Leu Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly 
            820                 825                 830         


Asn Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Ala Asn Lys 
        835                 840                 845             


Ile Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn 
    850                 855                 860                 


Ile Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu 
865                 870                 875                 880 


Ala Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys 
                885                 890                 895     


Lys Asn Glu Ile Glu Lys Asn His Lys Met Gln Glu Asn Leu His Arg 
            900                 905                 910         


Lys Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr 
        915                 920                 925             


Lys Lys Tyr Glu Lys Ala Ile Arg Asn Ile Gln Gln Tyr Thr His Leu 
    930                 935                 940                 


Lys Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu 
945                 950                 955                 960 


Leu Lys Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg 
                965                 970                 975     


Asp Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile 
            980                 985                 990         


Glu Glu Ile Phe Asn Phe Asp Asn  Ser Lys Asn Val Lys  Tyr Lys Asn 
        995                 1000                 1005             


Gly Gln  Ile Val Glu Lys Tyr  Ile Asn Phe Tyr Lys  Glu Leu Tyr 
    1010                 1015                 1020             


Lys Asp  Asp Thr Glu Lys Ile  Ser Ile Tyr Ser Asp  Lys Lys Val 
    1025                 1030                 1035             


Lys Glu  Leu Lys Lys Glu Lys  Lys Asp Leu Tyr Ile  Arg Asn Tyr 
    1040                 1045                 1050             


Ile Ala  His Phe Asn Tyr Ile  Pro Asn Ala Glu Ile  Ser Leu Leu 
    1055                 1060                 1065             


Glu Val  Leu Glu Asn Leu Arg  Lys Leu Leu Ser Tyr  Asp Arg 
    1070                 1075                 1080         


<210>  1286
<211>  1211
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1286

Met Lys Ile Thr Lys Arg Lys Trp Glu Asp Val Pro Pro Leu Phe Phe 
1               5                   10                  15      


His Arg Asp Lys Asp Ser Gly Arg Leu Ile Arg Gln Asp Asp Arg Glu 
            20                  25                  30          


His Asp Tyr Thr Asp Glu Leu Phe Arg Lys Thr Thr Val Asp Ser Ile 
        35                  40                  45              


Phe Ile Arg Ser Leu Gln Asn Arg Leu Leu Arg Ser Gln Asp Lys Glu 
    50                  55                  60                  


Gly Asn Lys Ile Gly Arg Asn Glu Ile Thr Glu Leu Val Glu Asn Leu 
65                  70                  75                  80  


Cys Lys Gly Ala Glu Ile Gln Lys Ser Ile Asp Glu Ile Lys Asp Ser 
                85                  90                  95      


Lys Ser Asn Val Lys Ala Leu Cys Asp Lys Thr Leu Thr Asp Tyr Gly 
            100                 105                 110         


Lys Ser Phe Ala Ala Glu Glu Gly Arg Thr Thr Leu Tyr Glu Ala Ile 
        115                 120                 125             


Leu Asn Leu Ala Lys Val Asn Ala Ile Gln Lys Ala Met Ala Glu Ala 
    130                 135                 140                 


Glu Leu Lys Gln Ile His Glu Ala Leu Lys Lys Glu Lys Glu Asp Arg 
145                 150                 155                 160 


Ile Asn Arg Val Gln Asn Ser Ile Lys Asn Asn Lys Ile Pro Leu Lys 
                165                 170                 175     


Val Asn Glu Asp Gly Thr Ile Ser Ala Asn Asn Asp Arg Ala Ser Trp 
            180                 185                 190         


Leu Leu Glu Leu Leu Lys Pro Val Ala Ser Glu His Asp Lys Gly Asp 
        195                 200                 205             


Arg Tyr Pro Val Leu Thr Glu Met Glu Gly Ile Val Ser Phe Asp Lys 
    210                 215                 220                 


Leu Cys Glu Glu Val Arg Asn Lys Ile His Gly Arg Lys Gly Arg Thr 
225                 230                 235                 240 


Arg Ser Ile Ala Met Ser Val Asp Glu Ala Val Lys Glu Tyr Leu Lys 
                245                 250                 255     


Glu Leu Trp Lys Lys His Ala Asp Arg His Arg Asp Met Arg Tyr Tyr 
            260                 265                 270         


Phe Gln Ala Val Lys Glu Tyr Phe Lys Glu Asn Phe Pro Ile Arg Thr 
        275                 280                 285             


Lys Gln Lys Gly Ala Gly Ile Arg Gln Ser Leu Leu Lys Glu Asp Thr 
    290                 295                 300                 


Val Val Ala Arg Leu Leu Asp Pro Lys His Met Ala Lys Ala Val Arg 
305                 310                 315                 320 


Arg Lys Leu Ile Asn Gln Ser Thr Gln Met His Ile Leu Tyr Gly Lys 
                325                 330                 335     


Leu Tyr Glu Tyr Cys Cys Arg Glu Asp Arg Asn Leu Pro Val Asn Ser 
            340                 345                 350         


Glu Thr Leu Gln Leu Ile Gln Val Leu Glu Ala Phe Lys Lys Gln Leu 
        355                 360                 365             


Met Thr Ala Val Leu Trp Ser Val Ser Arg Leu Cys Tyr Phe Tyr Glu 
    370                 375                 380                 


Phe Tyr Ser Gly Asp Ile Leu Leu Ala Glu Glu Tyr Arg Arg Asp Phe 
385                 390                 395                 400 


Leu Asn Gln Lys Asn Asp His Lys Asp Ile Gln Ala Cys Lys Glu Lys 
                405                 410                 415     


Leu Gln Asp Phe Phe Pro Leu Ala Glu Leu Gln Glu Lys Ile Arg Glu 
            420                 425                 430         


Cys Ala Asp Lys Asp Ile Asn Asn Ile Lys Asp Lys Ile Thr Asn Asp 
        435                 440                 445             


Val Leu Ala Cys Asn Asn Leu Leu Glu Glu Cys Val Phe Cys Ile Ser 
    450                 455                 460                 


Lys Leu Arg Asn Asn Ile Phe His Tyr Lys Asn Leu Ser Phe Thr Gln 
465                 470                 475                 480 


Ala Leu Lys His Ile Ala Asn Glu Ile Lys Glu Glu Asp Ile Pro Ile 
                485                 490                 495     


Ile Leu Arg Leu Tyr Lys Gln Asp Cys Glu Asn Leu Asn Asn Ala Phe 
            500                 505                 510         


Ala Ser Arg Ile Ser Ser Met Asn Ile Pro Leu Tyr Tyr Ser Thr Glu 
        515                 520                 525             


Phe Leu Leu Arg Ile Phe Lys Lys Gln Gly Val Glu Leu Ser Leu Tyr 
    530                 535                 540                 


Ser Ala Lys Tyr Gln Met Thr Pro Ser Phe Lys Arg Val Tyr Glu Arg 
545                 550                 555                 560 


Gly Lys Asn Leu Arg Leu Glu Tyr Glu Arg Glu Ser Met Arg Ser Asn 
                565                 570                 575     


Ile Ala Asn Glu Asp Gly Asn Asp Leu Gln Asn Gly Asn Trp Leu Arg 
            580                 585                 590         


Trp Phe Ser Gln Leu Lys Ala Gly Ile Val Asp Thr Asp Ala Gly Met 
        595                 600                 605             


Lys Gly Asp Ile Gly Asp Tyr Pro Asp Thr Ser Ala Asp Leu Gly Ile 
    610                 615                 620                 


Glu Ala Glu Thr Gly Thr Asn Thr Asp Ala Gln Arg Ala Met Arg Asn 
625                 630                 635                 640 


Leu Leu Gln Leu Ile Tyr Lys Tyr His Phe Leu Pro Glu Val Gln Lys 
                645                 650                 655     


Asn Glu Asn Ile Val Thr Asp Leu Ile Pro Lys Val Leu Glu Arg Asn 
            660                 665                 670         


Arg Lys Leu Ser Glu Val Arg Asn Arg Ser Asp Lys Thr Tyr Gly Tyr 
        675                 680                 685             


Lys Glu Ile Glu Glu Leu Tyr Lys Lys Asn Lys Gly Lys Lys Asp Ser 
    690                 695                 700                 


Leu Ser Glu Leu Leu Lys Asp Leu Gln Arg Lys Val Ser Glu Thr Glu 
705                 710                 715                 720 


Lys Glu Asn Gln Glu Leu Ala Arg Glu Lys Thr Asp Tyr Ala Gln Arg 
                725                 730                 735     


Phe Ile Leu Asp Ile Phe Ala Glu Ala Phe Ser Asn Phe Met Asp Asp 
            740                 745                 750         


Arg Tyr Glu Asp Glu Tyr Gln Glu Ile Met Asn Pro Lys Lys Asp Glu 
        755                 760                 765             


Glu Lys Ala Lys Lys Trp Ala Glu Leu Phe Thr Glu Lys Ala Asp Lys 
    770                 775                 780                 


Asp Asn Arg Lys Asp Glu Pro Leu Val Leu Lys Thr Ser Phe Asp Lys 
785                 790                 795                 800 


Asp Asn Ile Glu Lys Phe Leu Leu Val Leu Tyr Pro Leu Met Arg Leu 
                805                 810                 815     


Leu Asp Asp Lys Glu Leu Ser Glu Leu Gln Gln Gln Met Leu Arg Phe 
            820                 825                 830         


Arg Ala Ser Val Ser Gly Trp Gln Gly Ser Thr Asp Phe Asn Glu Asp 
        835                 840                 845             


Ile Ala Met Ala Glu Lys Ile Glu Glu Leu Ala Glu Leu Val Lys Leu 
    850                 855                 860                 


Thr Glu Pro Glu Ser Gln Cys Ala Glu Val Ser Trp Lys Asn Arg Ala 
865                 870                 875                 880 


Ile Glu Val Phe Glu Gln Phe Val Glu Gly Lys Met Ala Glu Tyr Gly 
                885                 890                 895     


Ala Phe Tyr Leu Gln Ser Asp Thr Leu Thr Pro Val Pro Arg Arg Asn 
            900                 905                 910         


Met Lys Glu Leu Leu Arg Ser Gly Ile Met Gly Val Phe Lys Lys Val 
        915                 920                 925             


Leu Leu Ser His Met Gln Ala Thr Lys Lys Asp Tyr Gly Val Tyr Ser 
    930                 935                 940                 


Gly Glu His Trp Asn Ile Asp Asp Pro Ala Gly Asn Pro Ile Lys Ser 
945                 950                 955                 960 


Ala Glu Gln Ala His Ala Leu Leu Gln Arg Leu His Asn Lys Tyr Thr 
                965                 970                 975     


Glu Ser Pro Ser Gln Phe Ser Tyr Glu Asp Tyr Lys Leu Tyr Asp Arg 
            980                 985                 990         


Thr Ile Arg Gln Leu Asp Glu Tyr  Asn Gln Ala Lys Lys  Asn Leu Ser 
        995                 1000                 1005             


Phe Gly  Ser Leu Tyr Glu Val  Cys Arg Ile Leu Leu  Asp Met Leu 
    1010                 1015                 1020             


Ser Arg  Trp Val Gly Phe Val  Gln Asp Trp Glu Arg  Asp Met Tyr 
    1025                 1030                 1035             


Phe Leu  Leu Leu Ala Trp Ala  Lys Gln Gly Lys Leu  His Asn Val 
    1040                 1045                 1050             


Thr Glu  Thr Asp Val Leu Glu  Val Phe Asn Glu Gly  Arg Val Ile 
    1055                 1060                 1065             


Cys Lys  Leu Asn Lys Lys Leu  Lys Asp Gly Asp Trp  Tyr Ala Phe 
    1070                 1075                 1080             


Ala Ser  Ile Tyr Cys Asn Asn  Ser Gly Glu Lys Leu  Glu Phe Leu 
    1085                 1090                 1095             


Gln Val  Arg Asn Phe Ile Ala  His Leu His Leu Leu  Arg Glu Ser 
    1100                 1105                 1110             


Glu Trp  Asn Gly Asp Glu Lys  Thr Gly Cys Ser Ala  Ile Glu Asp 
    1115                 1120                 1125             


Tyr Ile  Asn Lys Leu Arg Phe  Leu Leu Ser Tyr Asp  Gln Lys Arg 
    1130                 1135                 1140             


Met Asn  Ala Val Thr Lys Ala  Met Gln Gln Ile Phe  Glu Lys His 
    1145                 1150                 1155             


Lys Val  Ile Val Lys Phe Met  Val Glu Lys Gly Gly  Met Leu Lys 
    1160                 1165                 1170             


Val Lys  Asp Val Lys Pro Gly  Ile Ile Glu His Leu  Lys Gln Thr 
    1175                 1180                 1185             


Lys Arg  Ile Glu Ile Pro Cys  His Gly Glu Arg Phe  Thr Asp Ser 
    1190                 1195                 1200             


Leu Leu  Val Leu Met Lys Tyr  Gln 
    1205                 1210     


<210>  1287
<211>  1221
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1287

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Asp Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn Tyr Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Gly Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Gly Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Lys Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Arg Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Asp Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  Ser Met Leu Ser Ile  Tyr Ser Glu 
    1205                 1210                 1215             


Val Phe  Asp 
    1220     


<210>  1288
<211>  1079
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1288

Met Arg Ile Thr Lys Val Glu Val Asn Gly Lys Lys Val Ala Ile Gln 
1               5                   10                  15      


Arg Asn Met Lys Ser Gly Arg Leu Ile Phe Asn Glu Asp Ile Thr Asp 
            20                  25                  30          


Arg Thr Glu Glu Ile Leu Arg Leu Lys Gln Asp Ser Phe Tyr Lys Ser 
        35                  40                  45              


Val Ile Asn Lys Thr Ile Cys Lys Gly Lys Asp Ala Gln Gln Ile Lys 
    50                  55                  60                  


Val Leu Phe Glu Gly Leu Leu Tyr Glu Asp Lys Gln Ser Arg Val Asn 
65                  70                  75                  80  


Leu Thr Ala Val Lys Thr Met Asp Lys Asn Lys Leu Lys Glu Leu Phe 
                85                  90                  95      


Thr Arg Arg Phe Arg Gln Glu Phe Ser Tyr Val Ser Ser Lys Glu Ser 
            100                 105                 110         


Leu Glu Gln Glu Thr Phe Asp Leu Val Asn Leu Phe Ile Lys Ala Leu 
        115                 120                 125             


Ser Glu Gln Asn Gln Tyr Val Asp Trp Thr Thr Phe Ser Asp Lys Met 
    130                 135                 140                 


Gln Pro Tyr Thr Thr Trp Val Ser His Tyr Ile Glu Phe Arg Lys Thr 
145                 150                 155                 160 


Leu Leu Glu Lys Ser Ile Arg Gln Asn Lys Ile Tyr Ser Ser Thr Ser 
                165                 170                 175     


Leu Lys Ser Gln Val Leu Ser Gln Tyr Val Asp Ala Phe Ala Arg Ser 
            180                 185                 190         


Asp Met Asp Phe Asn Leu Glu Glu Val Ala Lys Arg Tyr Lys Leu Thr 
        195                 200                 205             


Asp Leu Val Lys Lys Leu His Lys Thr Phe Asp Asp Asn Asn Gln Ile 
    210                 215                 220                 


Lys Ala Ala Gly Ile Phe His Ile Lys Ile Lys Glu Ala Leu Gln Gln 
225                 230                 235                 240 


His Glu Arg Thr Leu Phe Asn Lys Glu Gln Gln Asn Phe Lys Gln Asn 
                245                 250                 255     


Arg Glu Asp Lys Glu Leu Val Leu Phe Thr Ala Glu Val Arg Gln Tyr 
            260                 265                 270         


Ile Ala Lys Asn Phe Pro Ile Lys Lys Asp Lys Ala Lys Lys Gly Lys 
        275                 280                 285             


Arg Ile Val Leu Ser Glu Ala Lys Ile Leu His Arg Ile Lys Gln Lys 
    290                 295                 300                 


Tyr Gln Asn Ala Met Thr Gln Tyr Leu Leu Asn Glu Gly Lys Arg Ala 
305                 310                 315                 320 


Ala Tyr Lys Leu Gly Asp Asn Thr Thr Ser Glu Asp Leu Thr Asn Ile 
                325                 330                 335     


Lys Ile Gly Glu Ala Phe Ala Leu Lys Phe Leu Asn Ala Cys Phe Phe 
            340                 345                 350         


Gly Ala Asn Ser Leu Arg Asn Ile Leu Glu Val Asp Gly Asp Val Leu 
        355                 360                 365             


Ser Ser Ser Ser Phe Arg Ser Ala Val Asp Asn Met Ser Gln Asn Lys 
    370                 375                 380                 


Glu Ala Glu Ile Arg His Asn Leu Glu Leu Phe Phe Ser Gly Ile Ser 
385                 390                 395                 400 


Glu Leu Cys Lys Asn Ser Glu Glu Leu Gly Glu Val Leu Trp Gly Leu 
                405                 410                 415     


Arg Gly Ala Ile Gln Arg Ile Arg Asn Asn Leu Val His Phe Asn Glu 
            420                 425                 430         


His Ser Trp Asn Gln Ile Leu Thr Leu Gly Asp Glu Lys Ile Glu Lys 
        435                 440                 445             


Ile Asp Lys Leu Tyr Val Glu Thr Lys Phe Gln Asp Leu Phe Thr Gln 
    450                 455                 460                 


Glu Leu Lys Asn Ile Pro Ile Leu Leu Lys Glu Lys Met Leu Thr Ala 
465                 470                 475                 480 


Lys Ile Phe Asp Tyr Tyr Pro Ala Ser Lys Leu Glu Asn Ser Phe Asp 
                485                 490                 495     


Lys Tyr Ser Leu Leu Thr Ser Val Ala Pro Phe Ala Pro Ser Phe Lys 
            500                 505                 510         


Arg Val His Thr Lys Gly Cys Asp Tyr Gln Tyr Ser Arg Lys Arg Asp 
        515                 520                 525             


Tyr Asn Leu Gln Leu Lys Val Tyr Lys Glu Lys Asp Lys Phe Ser Glu 
    530                 535                 540                 


Lys Glu Ala Glu Asn Ala Tyr Tyr Asn Leu Leu Lys Ile Ile Tyr Tyr 
545                 550                 555                 560 


Gln Met Phe Leu Pro Thr Phe Thr Lys Asp Tyr Arg Leu Phe Lys Glu 
                565                 570                 575     


Ser Thr Glu Phe Val Leu Lys Ile Asn Lys Gln Arg Asp Asn Gln Pro 
            580                 585                 590         


Ser Ala Phe Glu Phe Ile Arg Pro Met Glu Glu His Glu Thr Pro Ser 
        595                 600                 605             


Asp Tyr Met Gly Tyr Ile Gln Ser Ser Leu Met Gln Gln Gln Lys Lys 
    610                 615                 620                 


Val Asp Glu Gln Gly Lys Asp Asn Phe Phe Asn Arg Tyr Ile Thr Gln 
625                 630                 635                 640 


Ile Phe Ile Lys Gly Phe Asp Ser Tyr Ile Ile Lys Asn Asp Leu Glu 
                645                 650                 655     


Phe Ser Leu Ala Pro Val Lys Gln Glu Phe Asp Ser Glu Lys Ile Asp 
            660                 665                 670         


Leu Leu Asn Phe Lys Glu Glu Ile Asp Ala Lys Tyr Ile Pro Phe Trp 
        675                 680                 685             


Val Phe Cys Lys Val Leu Asn Thr Lys Met Leu Ser Glu Leu Arg Asn 
    690                 695                 700                 


Glu Met Ile Lys Phe Ser Arg Thr Glu Leu Ser Lys Glu Lys Arg Glu 
705                 710                 715                 720 


Ala Phe Ile Glu Ala Gln Lys Ile Ile Gly Leu Ala Leu Met Thr Val 
                725                 730                 735     


Asp Arg Gly Ser Ser Glu Trp Ile Lys Val Phe Ser Arg Lys Glu Asn 
            740                 745                 750         


Trp Gln Lys Thr Met Glu Met Tyr Val Ser Gln Asp Leu Leu Asn Glu 
        755                 760                 765             


Leu Pro Tyr Val Gln Glu Asp His Glu Thr Pro Ile Leu Phe Arg Ser 
    770                 775                 780                 


Val Glu Leu Val Lys Lys His Gly Ala Glu Lys Leu Leu Ser Lys Ile 
785                 790                 795                 800 


Val Gly Asp Asn Leu Val Thr Ala Glu Asp Val Gln Phe Tyr Gln Ala 
                805                 810                 815     


Asp His Asp Ile Glu Asn Val Ile Ala Ser Lys Glu Ala Met His Lys 
            820                 825                 830         


Lys Trp Glu Arg Asp Arg Arg Lys Ala Ser Glu Asn Asp Phe Lys Lys 
        835                 840                 845             


Ser Tyr Gly Ala Lys Ile Thr Lys Ile Ser Asp Tyr Arg Trp Asn Lys 
    850                 855                 860                 


Asn Lys Val Glu Leu Asn Tyr Ile Arg Ser Leu His Asn Leu Ala Val 
865                 870                 875                 880 


Asp Leu Ile Ser Arg Leu Thr Gly Phe Met Ala Ile Ala Asp Arg Asp 
                885                 890                 895     


Phe Gln Phe Leu Cys Asn Ala Leu Leu Ala Arg Arg Glu Ala Gly Phe 
            900                 905                 910         


Arg Val Lys Ser Trp Val Asp Leu Ser Arg Arg Val Lys Phe Lys Ser 
        915                 920                 925             


Tyr Glu Val Asp Tyr Ile Asn Gly Glu Val Glu Leu Ser Asn Gln Leu 
    930                 935                 940                 


Glu Glu Thr Ser Tyr Leu Ile Gly Lys Leu Glu Glu Ile Gln Ala Phe 
945                 950                 955                 960 


Cys Ile Asn Gly Gln Tyr Asn Gly Ala Lys Ser Val Arg Asn Glu Ile 
                965                 970                 975     


Asp His Trp Asp Lys Leu Arg Gly Gly Gly Ser Gln Ser Ile Leu Glu 
            980                 985                 990         


Leu Tyr Asn Ser Val Arg Glu Leu  Val Ser Tyr Asp Arg  Lys Leu Lys 
        995                 1000                 1005             


Asn Ala  Val Thr Lys Ser Leu  Ile Asp Leu Leu Glu  Gly His Gly 
    1010                 1015                 1020             


Ile Val  Leu Thr Leu Lys Asn  Lys Ser Leu Thr Glu  Ala Ser Arg 
    1025                 1030                 1035             


His Asp  Phe Glu Ile Lys Ser  Cys Lys Pro Lys Glu  Ile Arg His 
    1040                 1045                 1050             


Leu Gly  Asn Arg Gly Val Thr  Glu Lys Gln Val Ser  Asp Glu Tyr 
    1055                 1060                 1065             


Cys Gln  Leu Val Glu Arg Leu  Leu Lys Leu Lys 
    1070                 1075                 


<210>  1289
<211>  1078
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1289

Met Lys Leu Ser Lys Val Asn Asn Thr Arg Phe Phe Lys Glu Tyr Asp 
1               5                   10                  15      


Lys Gly Ser Leu Tyr Lys Leu Asn Glu Thr Lys Lys Leu Asp Leu Asp 
            20                  25                  30          


Glu His Ile Lys Leu Arg Met Glu Ser Ser Gln Lys Thr Phe Arg Asp 
        35                  40                  45              


Ile Phe Thr Met Leu Asn Lys Asn Asn Lys Tyr Ser Lys Glu Leu Ser 
    50                  55                  60                  


Asp Ile Ile Lys Glu Tyr Ala Ile Glu Tyr Ser Lys Leu Ser Leu Gly 
65                  70                  75                  80  


Asp Ile Leu Lys Ile Asn Thr Lys Ile Lys Asn Lys Thr Ile Glu Tyr 
                85                  90                  95      


Arg Ser Leu Asn Ser Phe Asn Arg Ile Tyr Lys Glu Arg Leu Lys Arg 
            100                 105                 110         


Ile Ser Lys Lys Asp Gly Glu Leu Phe Ala Phe Asp Val Asn Lys Thr 
        115                 120                 125             


Lys Glu Ile Asn Ser Phe Phe Lys Trp Leu Asn Glu Lys Tyr Ala Lys 
    130                 135                 140                 


Asn Phe Leu Ala Lys Asn Ala Lys Lys Ser Ile Glu Asn Asn Arg Ile 
145                 150                 155                 160 


Glu Ile Ala Asp Asn Lys Glu Lys Trp Leu Arg Ser Ile Thr Ala Asp 
                165                 170                 175     


Glu Asp Lys Ile Lys Leu Glu Arg Val Tyr Lys Lys Leu Arg Phe Leu 
            180                 185                 190         


Ile Leu Gly Glu Glu Lys Ala Gln Phe Thr Asn Asn Phe Ser Lys Asp 
        195                 200                 205             


Ile Met Ile Leu Asn Asp Ile Leu Arg Lys Asp Asp Ser Lys Asn Trp 
    210                 215                 220                 


Asn Glu Ala Lys Trp Tyr Asp Ser Leu Asn Phe Val Lys Arg Ile Tyr 
225                 230                 235                 240 


Ala Gln Leu Lys Asp Asp Leu Ser Glu Glu Glu Lys Tyr Asp Tyr Glu 
                245                 250                 255     


Ile Ile Val Gly Phe Leu Lys Glu Val Ile Ile Asp Leu Lys Pro Asn 
            260                 265                 270         


Ile Asn Gly Lys Gly Thr Leu Phe Val Lys Met Tyr Asp Gly Phe Lys 
        275                 280                 285             


Asp Ser Ser Thr Val Pro Leu Glu Lys Ile Ile Asn Leu Ile Ile Asn 
    290                 295                 300                 


Lys Thr Met Gly Lys Ile Lys Asn Tyr Phe Val Ser Asn Ile Ile Ser 
305                 310                 315                 320 


Cys Gly Lys Lys Val Tyr Leu Glu Asp Thr Phe Lys Ser Ser Lys Leu 
                325                 330                 335     


Ser Gly Asn Tyr Tyr Glu Leu Gln Lys Ala Tyr Asp Glu Ile Arg Val 
            340                 345                 350         


Arg Asn Ile Thr Ala Ile Ser Phe Ala Thr Asn Thr Ile Asn Asn Leu 
        355                 360                 365             


Phe Asn Lys Glu Asp Asn Phe Lys Asp Leu Asp Asn Met Val Ile Lys 
    370                 375                 380                 


Asn Asn Asn Glu Lys Val Glu Asp Lys Tyr Lys Gly Tyr Val Asp Glu 
385                 390                 395                 400 


Lys Ile Ser Leu Phe Phe Ser Leu Glu Ala Val Lys Asp Tyr Ile Glu 
                405                 410                 415     


Asn Asn Tyr Tyr Ala Phe Val Gln Gln Val Ile Ser Asn Leu Tyr Ser 
            420                 425                 430         


Leu Arg Asn Asn Asp Phe His Phe Ile Lys Ser Gly Gln Asn Val Cys 
        435                 440                 445             


Ser Asp Lys Leu Glu Lys Phe Val Lys Ile Glu Leu Asp Asn Tyr Tyr 
    450                 455                 460                 


Lys Ile Ile Asn Gln Lys Ile Asp Ser Ile Lys Leu Asn Lys Tyr Tyr 
465                 470                 475                 480 


Lys Lys Glu Glu Leu Leu Lys Val Phe Lys Asp Ile Gln Gly Gln Lys 
                485                 490                 495     


Asn Ile Val Pro Phe Met Pro Ser Phe Arg Lys Ile Lys Lys Tyr Leu 
            500                 505                 510         


Glu Leu Ser Lys Ile Asp Ile Glu Ser Asn Ile Glu Glu Gln Gln Val 
        515                 520                 525             


Gln Lys Asn Ala Glu Ile Tyr Leu Leu Lys Glu Ile Tyr Thr Thr Val 
    530                 535                 540                 


Phe Thr Asn His Phe Leu Lys Lys Lys Phe Thr Ile Ile Glu Glu Phe 
545                 550                 555                 560 


Lys Thr Cys Ile Leu Asn Asp Asn Asp Lys Gly Lys Lys Ala Phe Thr 
                565                 570                 575     


Ser Leu Glu Gly Met Leu Gly Gly Thr Met Ala Glu Val Ala Asn Met 
            580                 585                 590         


Leu Leu Thr Lys Tyr Met Ile Asp Asn Ser Ser Leu Thr Lys Lys Val 
        595                 600                 605             


Lys Asp Asp His Leu Lys Ile Ile Leu Asn Gln Leu Val Ala Lys Glu 
    610                 615                 620                 


Phe Glu Lys Tyr Ile Glu Asp Asn Tyr Lys Phe Leu Lys Glu Asp Lys 
625                 630                 635                 640 


Asn Asn Glu Ile Asn Asp Leu Asn Lys Ile Ser Glu Glu Glu Leu Lys 
                645                 650                 655     


Gln Ile Phe Asp Tyr Lys Ile Asp Lys Ile Asp Ile Ser Phe Tyr Ile 
            660                 665                 670         


Leu Ala Arg Leu Ile Pro Asn Ser Ile Val Ser Asp Leu Ser Asn Ser 
        675                 680                 685             


Tyr Ser Lys Phe Leu Gln Phe Thr Lys Asp Ile Ala Lys Lys Phe Lys 
    690                 695                 700                 


Leu Ile Glu Gly Val Glu Ile Ser His Lys Asn Leu Leu Thr Leu Leu 
705                 710                 715                 720 


Gly Tyr Ser Glu Asp Asp Ile Asn Lys Ile Val Tyr Ser Leu Asn Met 
                725                 730                 735     


Ala Leu Glu Tyr Asn Ser Thr Tyr Gly Ile Lys Ser Asp Glu Gly Lys 
            740                 745                 750         


Ser Phe Ile Asn Glu Ile Thr Pro Phe Phe Glu Asp Gly Thr Phe Lys 
        755                 760                 765             


Asp Glu Tyr Tyr Glu Asp Ile Phe Val Gln Asp Gly Lys Asn Val Ile 
    770                 775                 780                 


Tyr His Gly Ser Ile Ile Asn Leu Glu Lys Asn Phe Ile Tyr Asp Lys 
785                 790                 795                 800 


Ile Ser Lys Ile Tyr Asn Asp Ser Ser Leu Asp Leu Lys Val Lys Lys 
                805                 810                 815     


Arg Lys Asp Lys Asp Lys Lys Glu Glu Glu Met Asp Lys Tyr Ile Ser 
            820                 825                 830         


Leu Ser Lys Asp Gly Lys Tyr Lys Asn Ile Ile Asn Ile Tyr Glu Lys 
        835                 840                 845             


Ile Ala Asn Ser Arg Asp Gln Val Thr Glu Asp Asp Trp Lys Lys Val 
    850                 855                 860                 


Asn Glu Tyr Val Ala Leu Lys Asn Arg Val Leu Leu Gln Asp Ile Ser 
865                 870                 875                 880 


Asp Tyr Ser Thr Ile Leu Thr Glu Ile Gln Ser His Leu Ile Ser Tyr 
                885                 890                 895     


Phe Tyr Lys Tyr Glu Arg Asp Thr Met Tyr Phe Leu Leu Gly Leu Asp 
            900                 905                 910         


Tyr Leu Arg Lys Ser Val Lys Lys Pro Glu Ile Asn Asn Ile Phe Ser 
        915                 920                 925             


Tyr Gln Glu Lys Gly Gly Ser Val Asn Lys Lys Leu Ser Asp Tyr Leu 
    930                 935                 940                 


Lys Asn Ser Met Asn Ala Ile Phe Lys Lys Tyr Tyr Asp Glu Tyr Ile 
945                 950                 955                 960 


Val Asn Ser Ser Lys Val Lys Ile Asp Asn Lys Thr Val Arg Asn Ser 
                965                 970                 975     


Ile Asp His Phe Asp Gly Phe Lys Lys Asp Lys Ser Phe Phe Glu Ile 
            980                 985                 990         


Ile Val Asn Thr Tyr Lys Val Leu  Gly Tyr Asp Arg Lys  Leu Gln Asn 
        995                 1000                 1005             


Ser Val  Phe Lys Lys Leu Ile  Asn Ile Leu Glu Lys  His Arg Met 
    1010                 1015                 1020             


Asp Ile  Ser Lys Cys Ile Glu  Phe Lys Ser Ser Ser  Ile Thr Leu 
    1025                 1030                 1035             


Asn Lys  Asp Lys Ala Lys Asn  Ile Glu Val Glu Ile  Lys Val Lys 
    1040                 1045                 1050             


Asp Asn  Ser Tyr Lys Ala Phe  Asn Lys Asn Glu Lys  Tyr Ser Lys 
    1055                 1060                 1065             


Ile Phe  Leu Glu Ile Leu Asp  Ser Glu Thr 
    1070                 1075             


<210>  1290
<211>  958
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1290

Met Lys Leu Ser Lys Val Thr Tyr Arg Val Lys Asp Lys Asn Ala Lys 
1               5                   10                  15      


Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala Val Ala Asn Asn Ser Glu 
            20                  25                  30          


Asn Ala Gly Gly Val Leu Tyr His Val Pro Gly Val Asp Leu Ile Asp 
        35                  40                  45              


Leu Lys Glu Gln Met Leu Asp Arg Asp Arg Ser Val Arg Leu Leu Tyr 
    50                  55                  60                  


Asn Ile Phe Asn Gln Ile Gln Thr Gly Thr Lys Pro Lys Lys Trp Gly 
65                  70                  75                  80  


Asn Asp Glu Thr Leu Ser Val Asp Glu Asn Glu Arg Lys Ala Lys Glu 
                85                  90                  95      


Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp Arg Glu Ala Cys Ser Glu 
            100                 105                 110         


Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn Ser Val Leu Phe Tyr Ser 
        115                 120                 125             


Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg Met Asn Asp Asn Glu Ala 
    130                 135                 140                 


Ile Ile Val Lys Met Gln Tyr Glu Asn Arg Leu Ser His Phe Thr Gly 
145                 150                 155                 160 


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Asn Ser Leu Val 
                165                 170                 175     


Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp Ser Val Asn Ala Met Val 
            180                 185                 190         


Val Phe Ile Asn Asn Ile Gly Asn Gly Asn Ile Ser Asp Lys Asp Lys 
        195                 200                 205             


Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile Arg Asn Asp Phe Ser Lys 
    210                 215                 220                 


Leu Asn Pro Asn Val Gln Ser Ser Gln Gly Ala Asn Met Val Arg Ser 
225                 230                 235                 240 


Val Arg Asn Gln Asn Met Val Val Gln Pro Gln Gly Asp Ile Val Ser 
                245                 250                 255     


Phe Pro Leu Val Ser Asp Glu Gly Lys Asn Thr Val Thr Asn Lys Asn 
            260                 265                 270         


Val Glu Lys Lys Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
        275                 280                 285             


Asp Asp Glu Glu Arg Met Glu Asn Leu Arg Lys Leu Arg Arg Ile Ile 
    290                 295                 300                 


Asp Val Tyr Phe Ser Ser Pro Ser His Tyr Gln Lys Asp Met Asp Ile 
305                 310                 315                 320 


Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys Phe Val Val Trp Lys Lys 
                325                 330                 335     


His Glu Thr Gly Lys Lys Asn Thr Glu Leu Phe Val Asp Ile Pro Asp 
            340                 345                 350         


Glu Leu Phe Thr Ala Glu Thr Glu Lys Ile Lys Leu Asp Ala Val Leu 
        355                 360                 365             


Glu Lys Gln Ala Arg Lys Arg Leu Thr Asp Ser Ile Arg Lys Gln Asn 
    370                 375                 380                 


Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
385                 390                 395                 400 


Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser Ile Asn Gln Tyr Trp Ile 
                405                 410                 415     


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Ser Cys Lys Ala 
            420                 425                 430         


Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr Leu Thr Glu Lys Val Trp 
        435                 440                 445             


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
    450                 455                 460                 


Val Ile Tyr Asn Phe Thr Val Asp Asp Ile Trp Lys Asp Lys Lys Val 
465                 470                 475                 480 


Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile Lys His Gly Ile Thr Ser 
                485                 490                 495     


Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu Ala Leu Gln Arg Glu Leu 
            500                 505                 510         


Ala Val Asn Val Ala Phe Ala Ala Asn Asn Leu Ala Arg Ala Val Cys 
        515                 520                 525             


Asp Met Thr Asn Leu Lys Asp Lys Glu Ser Asp Phe Leu Ile Trp Asn 
    530                 535                 540                 


Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
545                 550                 555                 560 


Val Ser Val Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
                565                 570                 575     


Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn Lys Tyr Asp Tyr Glu Val 
            580                 585                 590         


Cys Phe Ile Asp Asp Leu Arg Lys Ala Val Tyr Ala Ala Arg Asn Glu 
        595                 600                 605             


Ser Phe His Phe Lys Thr Ala Leu Val Asn Asn Asp Ile Trp Asn Thr 
    610                 615                 620                 


Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu Thr Glu Ile Cys Leu Asp 
625                 630                 635                 640 


Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Pro Val Phe Tyr Ser 
                645                 650                 655     


Asp Asn Asp Leu Lys Lys Met Leu Asp His Leu Tyr Asn Asn Lys Val 
            660                 665                 670         


Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Met Val Arg Lys 
        675                 680                 685             


Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu Lys Tyr Gln Lys Pro Gly 
    690                 695                 700                 


Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr Ser Ala Cys Tyr Tyr Leu 
705                 710                 715                 720 


Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Glu Ala Leu 
                725                 730                 735     


Ala Leu Phe Glu Glu Ser Val Asn Asn Leu Lys Gly Asp Asn Lys Asp 
            740                 745                 750         


Gln Glu Leu Ala Val Lys Asn Phe Arg Asn Asn Tyr Lys Asn Ile Lys 
        755                 760                 765             


Ser Ser Cys Thr Ser Phe Ser Gln Val Cys Gln Met Tyr Met Thr Glu 
    770                 775                 780                 


Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys Val Arg Ser Ser Lys Asp 
785                 790                 795                 800 


Ser Ile Val Asp Lys Pro Ile Tyr Gln His Tyr Lys Leu Leu Leu Lys 
                805                 810                 815     


Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr Leu Gln His Asn Lys Glu 
            820                 825                 830         


Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys Val Asn Cys Leu Lys Glu 
        835                 840                 845             


Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp Thr Ala Lys Lys Tyr Val 
    850                 855                 860                 


Ser Leu Cys Glu Glu Val Arg Lys Ser Pro Glu Leu Gln Lys Trp Tyr 
865                 870                 875                 880 


Ile Val Gly Lys Phe Leu Asn Ser Arg Ser Leu Asn Leu Met Ala Gly 
                885                 890                 895     


Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn Asp Ile Lys Arg Arg Ala 
            900                 905                 910         


Asp Gly Ile Gly Asn Glu Leu His Val Ile Ala Gln Asn Leu Asp Val 
        915                 920                 925             


Val Asp Lys Trp Val Gln Val Ile Glu Val Cys Leu Leu Leu Ser Ser 
    930                 935                 940                 


Arg Val Ser Asn Asp Lys Gly Met Tyr Ile Phe Val His Ala 
945                 950                 955             


<210>  1291
<211>  1064
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1291

Leu Ser Ile Ala Asp Thr Lys Lys Lys Pro Leu Trp Glu Tyr Leu Ile 
1               5                   10                  15      


Lys Tyr Ala Asp Ser Ser Arg Gln Arg Glu Leu Met Tyr Asp Ile Arg 
            20                  25                  30          


Lys Lys Ile Ile Leu Tyr Val Ala Gly Ile Glu Glu Tyr Glu Asn Ile 
        35                  40                  45              


Lys Glu Asp Ser Gly Leu Ser Lys Val Ser Trp Ser Lys Tyr Asn Ile 
    50                  55                  60                  


Ser Asp Asn Lys Met Phe Phe Asp Ile Asn Ser Cys Thr Asp Lys Arg 
65                  70                  75                  80  


Lys Gln Asn Leu Glu Ile Lys Ile Arg Glu Ala Asn Ile Glu His Tyr 
                85                  90                  95      


Arg Asn Ala Ser Ser Lys Leu Cys Asp Asp Glu Ser Ile Phe Trp Phe 
            100                 105                 110         


Gln His Phe Glu Gly Val Ile Glu Thr Leu Phe Ser Lys Lys Ser Lys 
        115                 120                 125             


Ile Ser Glu Glu Arg Leu Gly Cys Ala Tyr Ile Cys Asp Tyr Leu Trp 
    130                 135                 140                 


Lys Asp Phe Leu Ser Tyr Leu Ala Ala Lys Tyr Ile Asp Leu Gly Lys 
145                 150                 155                 160 


Gly Val Tyr His Phe Thr Met Lys Asp Lys Leu Asp Met Leu Asn Lys 
                165                 170                 175     


Asn Glu Ala Val Thr Asp Leu Arg Phe Gly Ile Val Ser Glu Lys Tyr 
            180                 185                 190         


Glu Lys Gly Ile Thr Ser Phe Asp Tyr Glu Arg Ile Lys Ala Glu Glu 
        195                 200                 205             


Glu Leu Asp Arg Asn Ile Ala Ala Tyr Val Thr Phe Ala Ala Asp Ile 
    210                 215                 220                 


Phe Ala Lys Ser Val Ile Lys Ser Asp Tyr Arg Thr Lys Lys Asp Asn 
225                 230                 235                 240 


Asn Ser Asp Val Leu Gln Tyr Ser Asp Lys Glu Phe Arg Asn Ser Glu 
                245                 250                 255     


Val Ile Arg Asp Asn Ala Glu Lys Asn Ile Leu Gln Tyr Trp Gly Gly 
            260                 265                 270         


Tyr Ser Arg Trp Cys Thr Glu Asn Ser Lys Leu Pro Glu Asn Asn Lys 
        275                 280                 285             


Val Ser Asp Phe Gly Lys Leu Asp Val Ser Asp Leu Cys Ile Asp Ile 
    290                 295                 300                 


Lys Lys His Leu Ala Gly Ile Arg Asn Ser Ser Val His Tyr Thr Thr 
305                 310                 315                 320 


Lys Ile Lys Asn Glu Ser Ala Ala Asp Gly Ser Asn Val Lys Ile Leu 
                325                 330                 335     


Phe Glu Lys Asp Leu Ala Asp Ile Asn Ile Ile Tyr Ala Asp Lys Tyr 
            340                 345                 350         


Tyr Ser Asn Asn Val Trp Met Phe Tyr Ser Leu Glu Asp Ile Asn Lys 
        355                 360                 365             


Leu Ile Ala Phe Leu Tyr Lys Glu Lys Arg Val Ile Arg Gln Val Gln 
    370                 375                 380                 


Ile Pro Ser Phe Ser Arg Ile Leu Lys Arg Lys Ala Met Gln Asp Val 
385                 390                 395                 400 


Ile Asn Glu Ile Phe Lys Asp Asp Phe Asp Glu Asn Ile Val Asn Pro 
                405                 410                 415     


Glu Leu Lys Glu Lys Tyr Arg Asn Ser Leu Tyr Phe Met Leu Lys Glu 
            420                 425                 430         


Ile Tyr Tyr Asn Ala Phe Ile Ile Gln Pro Glu Leu Lys Glu Lys Phe 
        435                 440                 445             


Lys Asp Lys Ile Lys Thr Met Lys Ser Glu Leu Tyr Asn Lys Leu Lys 
    450                 455                 460                 


Thr Ile Asp Lys Lys Glu Tyr Lys Ala Leu Tyr Cys Met Leu Ser Asn 
465                 470                 475                 480 


Glu Glu Ser Ala Leu Lys Asn Phe Ala Asp Arg Ile Tyr Ser Val Asp 
                485                 490                 495     


Gly Asp Asn Val Ser Phe Ala Asp Ile Cys Lys Ile Leu Met Thr Asp 
            500                 505                 510         


Tyr Asn Met Gln Asn Gln Glu Lys Lys Asn Ile Glu Ser Met Glu Gln 
        515                 520                 525             


Lys Lys Lys Asn Lys Gly Lys Asp Glu Asn Tyr Lys His Phe Pro Leu 
    530                 535                 540                 


Leu Leu His Lys Val Leu Lys Glu Leu Phe Ile Glu Tyr Leu Lys Gln 
545                 550                 555                 560 


Thr His Glu Leu Glu Phe Leu Arg Asn Asn Ile Cys Ile Lys Ser Asp 
                565                 570                 575     


Val Thr Met Glu Ser Phe Glu Ser Gln Ile Lys Gly Val Glu Ile Tyr 
            580                 585                 590         


Lys Asp Leu Lys Glu Lys Ile Asp Lys Asn Asn Ser Leu Leu Asp Trp 
        595                 600                 605             


Tyr Val Ile Ala His Phe Leu Met Pro Lys Gln Leu Asn His Leu Ile 
    610                 615                 620                 


Gly Asn Ile Lys Asn Tyr Ile Gln Phe Ala Thr Asn Ile Asp Lys Arg 
625                 630                 635                 640 


Ala Glu Ser Val Lys Asn Leu Thr Glu Ser Gly Met Val Lys Arg Ile 
                645                 650                 655     


Gln Tyr Tyr Asp Asp Ile Val Arg Thr Leu Glu Phe Ser Ala Gln Tyr 
            660                 665                 670         


Ile Gly Lys Ile Ser Asn Asn Ile Asn Asp Tyr Phe Asn Ser Glu Asp 
        675                 680                 685             


Glu Tyr Val Ser Phe Leu Ser Lys Tyr Val Gly Phe Ile Asn Asp Lys 
    690                 695                 700                 


Ser Glu Asp Val Leu Thr Glu Leu Lys Asp Phe Cys Arg Glu Lys Ile 
705                 710                 715                 720 


Asn Asn Gly Ser Gln Ile Ile Gly Ile Tyr Tyr Gly Gly Asp Asn Val 
                725                 730                 735     


Ile Ile Asn Arg Asn Val Ile Tyr Ala Gln Met Tyr Ser Asn Ala Glu 
            740                 745                 750         


Val Phe Ser Asn Ile Tyr Lys Lys Val Thr Lys Asn Asp Ile Ile Asn 
        755                 760                 765             


Tyr Tyr Glu Lys Gln Asn Asp Leu Lys Asp Val Phe Lys Ser Gly Val 
    770                 775                 780                 


Cys Gln Asn Glu Asp Glu Gln Arg Ser Leu Cys Glu Phe Gln Gln Leu 
785                 790                 795                 800 


Lys Asn Arg Ile Glu Leu Thr Glu Leu Ser Thr Tyr Ala Asp Met Val 
                805                 810                 815     


Asn Asp Phe Met Ala Gln Phe Val Glu Trp Ala Tyr Leu Arg Glu Arg 
            820                 825                 830         


Asp Leu Met Tyr Phe Gln Leu Gly Ile His Tyr Ile Arg Leu Phe Tyr 
        835                 840                 845             


Ser Asp Asn Val Leu Asp Glu Lys Tyr His Lys Leu Ser Asp Asn Val 
    850                 855                 860                 


Ile Asp Ile Glu Glu Gly Ala Leu Leu Tyr Gln Ile Val Ala Met Tyr 
865                 870                 875                 880 


Asp Tyr Glu Leu Arg Ile Phe Glu Thr Asp Asn Ser Gly Asn Ala Lys 
                885                 890                 895     


Arg Ile Gly Gln Gly Gly Pro Gly Lys Ser Ile Pro Val Phe Leu Lys 
            900                 905                 910         


Lys Tyr Cys Ser Gly Thr Asp Val Tyr Glu Cys Gly Leu Glu Leu Phe 
        915                 920                 925             


Glu Asp Ile Asn Gln His Glu His Ile Ile Arg Phe Arg Asn Asp Ile 
    930                 935                 940                 


Ala His Met Arg Tyr Met Ser Asn Gln Ala Met Asn Ile Met Ser Ile 
945                 950                 955                 960 


Val Ser Asn Ile Tyr Lys Ser Phe Phe Ala Tyr Asp Thr Lys Leu Lys 
                965                 970                 975     


Lys Ser Ile Ser Leu Val Phe Lys Asn Ile Leu Met Arg Tyr Gly Val 
            980                 985                 990         


Ile Ala Asp Leu Val Phe Ser Tyr  Asn Asn Lys Asn Gln  Ser Ile Lys 
        995                 1000                 1005             


Asp Asp  Met Asp Ile Asn Ile  Ile Asn Ile Lys Asn  Leu Lys Ser 
    1010                 1015                 1020             


Asp Lys  Tyr Val Tyr Lys Ile  Val Asn Glu Asp Ile  Val Lys Gln 
    1025                 1030                 1035             


Val Glu  Ile Glu Ile Arg Asn  Gln Val Phe Leu Glu  Arg Ser Glu 
    1040                 1045                 1050             


Glu Arg  Arg Val Gly Lys Glu  Cys Arg Ser Arg 
    1055                 1060                 


<210>  1292
<211>  1130
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1292

Met Lys Val Ser Lys Val Lys Val Lys Val Gly Ala Gly Arg Ser Ser 
1               5                   10                  15      


Glu Arg Met Val Phe Met Arg Arg Thr Ser Lys Ile Gly Ser Leu Val 
            20                  25                  30          


Tyr Glu Asp Glu Gln Arg Asn Gly Lys Pro Glu Thr Asp Asp Lys Thr 
        35                  40                  45              


Thr Ser Ile Leu Pro Asp Lys Lys Arg Asp Ser Phe Ile Leu Ser Ile 
    50                  55                  60                  


Val Asn Lys Thr Ile Pro Lys Lys Glu Ile Val Lys Lys Asn Leu Gly 
65                  70                  75                  80  


Lys Gly Phe Val Asn Glu Tyr Tyr Asn Ala Ile Ala Gly Ile Ile Asp 
                85                  90                  95      


Ser Phe Leu Glu Lys Lys Ile Val Asp Arg Lys His Tyr Ile Ile Val 
            100                 105                 110         


Asn Lys Leu Thr Glu Glu Glu Ile Lys Gln Tyr Leu Asn His Arg Phe 
        115                 120                 125             


Gln Glu Ala Asn Tyr Lys Tyr Val Arg Asp Lys Glu Glu Val Asn Phe 
    130                 135                 140                 


Asn Leu Pro Lys Leu Leu Lys Glu Ser Ala Lys Ser Asn Ser Thr Ala 
145                 150                 155                 160 


Pro Leu Gln Pro Tyr Lys Glu Trp Ala Glu Trp His Ile Glu Thr Lys 
                165                 170                 175     


Ser Val Arg Leu Ile Arg Ser Ile Gln Asn Asn Arg Leu Val Ile Asp 
            180                 185                 190         


Thr Gln Glu Glu Ala Glu Asn Met Ser Pro Arg Lys Arg Ala Leu Leu 
        195                 200                 205             


Lys Trp Glu Asn Glu Phe Leu Leu Ser His Lys Leu Asp Leu Gln Asp 
    210                 215                 220                 


Val Glu Lys Thr Tyr Leu Ile Asp Asp Leu Ile His Ala Leu His Glu 
225                 230                 235                 240 


Val Thr Tyr Thr Thr Asn Asp Lys Gly Phe Ile Asn Gly Asn Glu Tyr 
                245                 250                 255     


His Arg Phe Leu Lys Lys Ala Leu Gln Ser His Gln Gln Asn Ile Phe 
            260                 265                 270         


Gly Ser Arg Glu Thr Pro Asn Lys Val Asn Arg Glu Asn Ala Glu Leu 
        275                 280                 285             


Tyr Ser Tyr Asn Met Glu Val Val Lys Tyr Leu Glu His Tyr Phe Pro 
    290                 295                 300                 


Ile Lys Lys Thr Asn Arg Arg Asn Thr Leu Asp Thr Lys Asp Tyr Tyr 
305                 310                 315                 320 


Leu Asn Gly Ile Asn Ile Lys Asp Arg Val Arg Lys Gln Leu Glu Asn 
                325                 330                 335     


Ala Val Arg Asn Asn Leu Val Arg Gln Gly Lys Tyr Thr Leu His Thr 
            340                 345                 350         


Leu Thr Thr Asp Thr Ala Asn Ser Asp Asn Leu Ser Lys Ile Lys Ala 
        355                 360                 365             


Asp Glu Gly Phe Ala Leu Thr Met Leu Asn Gln Cys Ala Phe Ala Ala 
    370                 375                 380                 


Asn Asn Val Arg Asn Ile Ile Asp Pro Thr Gln Val Glu Asp Ile Leu 
385                 390                 395                 400 


Leu Asp Arg Pro Phe Asn Glu Ser Leu Glu Lys Phe Asn Ser Ala Gln 
                405                 410                 415     


Met Leu His Leu Ser Ser Phe Phe Asp Val Lys Glu Phe Asn Glu Pro 
            420                 425                 430         


Leu Arg Ala Ile Arg Asp Ala Val Ala Lys Ile Arg His Asn Ile Ile 
        435                 440                 445             


His Tyr Lys Val Asn Ala Leu Asn Val Ile Phe Lys Ile Glu Thr Phe 
    450                 455                 460                 


Gly Ser Thr Glu Lys Gln Tyr Lys Asp Thr Ile Phe Gly Ser Leu Leu 
465                 470                 475                 480 


Gln Ala Asp Met Met Asn Val Ser Glu Ser Leu Ala Lys Gln Leu Met 
                485                 490                 495     


Thr Gly Asn Val Leu Glu Tyr Tyr Pro Met Leu Glu Leu Lys Ser Phe 
            500                 505                 510         


Phe Ser Lys Asn Ser Ile Ser Leu Tyr Arg Ser Val Ile Pro Phe Ala 
        515                 520                 525             


Pro Gly Phe Lys Arg Val Met Lys Lys Gly Glu Asn Tyr Gln Asn Ala 
    530                 535                 540                 


Asn Asn Lys Asp Asp Lys Ser Lys Tyr Tyr Asn Leu Lys Ile Glu Ser 
545                 550                 555                 560 


Phe Leu Pro Gln Glu Ser Phe Thr Lys Glu Ala Tyr Asp Ala Arg Tyr 
                565                 570                 575     


Phe Leu Leu Lys Leu Ile Tyr Asn Asn Ile Phe Leu Pro Lys Phe Thr 
            580                 585                 590         


Glu Ser Thr Asp Trp Ser Lys Ser Thr Val Asn Gly Val Ile Ala Leu 
        595                 600                 605             


Asn Arg Glu Glu Asn Val Arg Lys Gly Lys Lys His Lys Ile Ala Phe 
    610                 615                 620                 


Ala Glu Ile Arg Leu Met Asp Ser Arg Asp Thr Ile Gly Thr Tyr Ala 
625                 630                 635                 640 


Ala Tyr Leu Gln Ser Cys Ala Ile Ile Glu Ala Asn Lys Lys Pro Asp 
                645                 650                 655     


Ala Ala Lys Asp Glu Thr Val Leu Leu Asn Phe Glu Lys Leu Ile Leu 
            660                 665                 670         


Gln Ile Phe Ile Lys Gly Phe Asp Asp Phe Leu Arg Arg Tyr Gly Met 
        675                 680                 685             


Leu Lys Phe Val Gln Gln Pro Ser Leu Gln Phe Lys Ser Gly Ala Lys 
    690                 695                 700                 


Asp Glu Thr Lys Gln Arg Lys Asp Trp Ala Lys Glu Val Glu Gly Ser 
705                 710                 715                 720 


Leu His Ala Pro Val Asn Asp Ile Asn Pro Thr Glu Ser Ser His Ile 
                725                 730                 735     


Ser Phe Tyr Val Phe Cys Lys Leu Leu Asp Ala Pro His Leu Asn Asp 
            740                 745                 750         


Leu Arg Asn Glu Leu Ile Lys Tyr Tyr Arg Ser Gln Ser His Arg Pro 
        755                 760                 765             


Gln Lys Ile Lys Asn Ile Lys Tyr Leu Leu Ser Ile Ile Glu Leu Cys 
    770                 775                 780                 


Leu Leu Ser Val Asp Ala Ser Glu Leu Asn Lys Leu Phe Thr Asp Ala 
785                 790                 795                 800 


Asp Asn Ser Ile Asn Asp Arg Leu Leu Ala Phe Leu Glu Lys Asn Lys 
                805                 810                 815     


Thr Val Ala Asp Tyr Glu Asp Leu Tyr Thr Gln Ser Asp Asn Glu Thr 
            820                 825                 830         


Met Val Leu His Arg Thr Ile Ala Lys Ala Tyr Lys Tyr Gly Thr Arg 
        835                 840                 845             


Lys Val Leu Glu Gln Val Ile Asp Ser Asp Pro Ser Tyr Arg Val Thr 
    850                 855                 860                 


Val Ser Glu Tyr Glu Glu Trp Lys Asn Leu Lys Glu Asn Val Glu Glu 
865                 870                 875                 880 


Trp Ile Ala Cys Arg Glu Lys Leu His Ala Lys Trp Val Lys Val Glu 
                885                 890                 895     


Arg Val Pro Lys Met Lys Glu Gly Glu Met Lys Asp Asp Met Lys Glu 
            900                 905                 910         


Tyr Val Glu Val Cys Ser Thr Ile Asp Arg Tyr Asn Trp Leu Asp Asn 
        915                 920                 925             


Lys Val His Leu Glu His Ile Asn Lys Leu His Asn Leu Thr Ile Asp 
    930                 935                 940                 


Leu Leu Gly Arg Met Ala Gly Phe Asn Thr Leu Phe Glu Arg Asp Leu 
945                 950                 955                 960 


Gln Tyr Tyr Cys Asn Cys Asn Glu Lys Val Arg Ser Leu Leu Lys Pro 
                965                 970                 975     


Glu Ser Ser Glu Gly Phe Asp Phe Ser Lys Gly Leu Pro Lys Phe Thr 
            980                 985                 990         


Glu Glu Gln Asn Ser Ile Leu Phe  Gln Thr Phe Leu Val  Glu Gly Tyr 
        995                 1000                 1005             


Arg Asp  Thr Arg Asn Phe Val  Ala His Phe Asn Phe  Leu Asn Ser 
    1010                 1015                 1020             


Phe Glu  Asp Ser Tyr Ser Lys  Asn Arg Tyr Ser Leu  Ile Asp Val 
    1025                 1030                 1035             


Ile Asn  Arg Leu Arg Lys Gln  Phe Lys Tyr Asp Arg  Lys Leu Lys 
    1040                 1045                 1050             


Asn Ala  Val Ser Lys Ala Ile  Ile Lys Leu Phe Glu  Lys His Gly 
    1055                 1060                 1065             


Met Val  Leu Thr Phe Ser Phe  Glu Gly Asp His Glu  Leu Val Val 
    1070                 1075                 1080             


Lys Asp  Val Phe Pro Arg Lys  Ile Ile His Phe Ser  Lys Leu Lys 
    1085                 1090                 1095             


Leu Asp  Lys Lys Ile Glu Gln  Lys Pro Lys Val Glu  Thr Asp Met 
    1100                 1105                 1110             


Val Pro  Lys Glu Phe Cys Ala  Met Cys Lys Phe Leu  Leu Glu Leu 
    1115                 1120                 1125             


Lys Lys  
    1130 


<210>  1293
<211>  1210
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1293

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Glu 
1               5                   10                  15      


Glu Gln Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile 
            20                  25                  30          


Asp Gly Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys 
        35                  40                  45              


Leu Tyr Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys 
    50                  55                  60                  


Trp Asn Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala 
65                  70                  75                  80  


Gln Gln Lys Asn Ile Lys Ile Glu Asn Tyr Lys Trp Arg Glu Ala Cys 
                85                  90                  95      


Ser Lys Tyr Val Lys Ser Ser Gln Lys Thr Ile Asn Tyr Val Ile Phe 
            100                 105                 110         


Tyr Ser Tyr Gly Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn 
        115                 120                 125             


Glu Asp Ile Leu Lys Lys Met Gln Glu Glu Glu Lys Leu Pro Lys Phe 
    130                 135                 140                 


Ser Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser 
145                 150                 155                 160 


Leu Val Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala 
                165                 170                 175     


Met Val Val Phe Leu Glu Cys Ile Gly Lys Ser Asn Ile Ser Asp His 
            180                 185                 190         


Glu Lys Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe 
        195                 200                 205             


Ser Lys Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val 
    210                 215                 220                 


Arg Ser Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg 
225                 230                 235                 240 


Phe Leu Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn 
                245                 250                 255     


Lys Asn Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala 
            260                 265                 270         


Asn Leu Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg 
        275                 280                 285             


Ile Leu Asp Val Tyr Phe Ser Ala Pro Asn Tyr Tyr Glu Lys Asp Met 
    290                 295                 300                 


Asp Ile Thr Leu Ser Asp Asn Ile Glu Lys Gly Lys Phe Asn Val Trp 
305                 310                 315                 320 


Glu Lys His Glu Cys Gly Lys Lys Val Thr Asp Leu Phe Val Asp Ile 
                325                 330                 335     


Pro Asp Val Leu Met Glu Ala Gly Ala Glu Asn Ile Lys Leu Asp Ala 
            340                 345                 350         


Val Val Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys 
        355                 360                 365             


Gln Asn Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr 
    370                 375                 380                 


Asn Ser Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr 
385                 390                 395                 400 


Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys 
                405                 410                 415     


Lys Ala Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys 
            420                 425                 430         


Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu 
        435                 440                 445             


Gly Lys Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile 
465                 470                 475                 480 


Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg 
                485                 490                 495     


Glu Leu Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala 
            500                 505                 510         


Val Cys Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu 
        515                 520                 525             


Trp Lys Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met 
    530                 535                 540                 


Ala Ser Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp 
545                 550                 555                 560 


Asp Ile Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn 
                565                 570                 575     


Tyr Glu Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala 
            580                 585                 590         


Arg Asn Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys 
        595                 600                 605             


Trp Asn Thr Glu Leu Phe Gly Lys Ile Phe Lys Arg Glu Thr Glu Phe 
    610                 615                 620                 


Cys Leu Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met 
625                 630                 635                 640 


Phe Tyr Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser 
                645                 650                 655     


Arg Ser Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile 
            660                 665                 670         


Val Arg Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln 
        675                 680                 685             


Lys Pro Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys 
    690                 695                 700                 


Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp 
705                 710                 715                 720 


Arg Ala Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp 
                725                 730                 735     


Asp Glu Glu Gln Lys Arg Ala Val Asp Asn Phe Lys Lys Tyr Phe Ser 
            740                 745                 750         


Asp Ile Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr 
        755                 760                 765             


Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser 
    770                 775                 780                 


Ser Asn Asp Ser Ile Phe Asp Gln Pro Ile Tyr Gln His Tyr Lys Val 
785                 790                 795                 800 


Leu Leu Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn 
                805                 810                 815     


Asn Lys Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu 
            820                 825                 830         


Ile Arg Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg 
        835                 840                 845             


Lys Tyr Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln 
    850                 855                 860                 


Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu 
865                 870                 875                 880 


Met Val Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys 
                885                 890                 895     


Arg Arg Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp 
            900                 905                 910         


Val Glu Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu 
        915                 920                 925             


Leu Ala Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys 
    930                 935                 940                 


Asp Asp Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val 
945                 950                 955                 960 


Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Asp Phe Ser Asn Glu Glu 
                965                 970                 975     


Gln Ser Asp Leu Tyr Val Asp Pro Lys Asn Pro Lys Val Asn Arg Asn 
            980                 985                 990         


Ile Val His Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
        995                 1000                 1005             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1010                 1015                 1020             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1025                 1030                 1035             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1040                 1045                 1050             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1055                 1060                 1065             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp Ser Phe Met  Arg Glu Arg 
    1070                 1075                 1080             


Asp Leu  Leu Tyr Phe Gln Leu  Gly Phe His Tyr Asp  Cys Leu Arg 
    1085                 1090                 1095             


Asn Asp  Ser Lys Lys Pro Glu  Arg Tyr Lys Asn Ile  Lys Val Asp 
    1100                 1105                 1110             


Glu Asn  Ser Ile Lys Asp Ala  Ile Leu Tyr Gln Ile  Ile Gly Met 
    1115                 1120                 1125             


Tyr Val  Asn Gly Val Thr Val  Tyr Ala Pro Glu Lys  Asp Asp Asp 
    1130                 1135                 1140             


Lys Leu  Lys Glu Gln Cys Val  Lys Gly Gly Val Gly  Val Lys Val 
    1145                 1150                 1155             


Ser Ala  Phe His Arg Tyr Ser  Lys Tyr Leu Gly Leu  Asn Glu Lys 
    1160                 1165                 1170             


Thr Leu  Tyr Asn Ala Gly Leu  Glu Ile Phe Glu Val  Val Ala Glu 
    1175                 1180                 1185             


His Glu  Asp Ile Ile Asn Leu  Arg Asn Gly Ile Asp  His Phe Lys 
    1190                 1195                 1200             


Tyr Tyr  Leu Gly Asp Tyr Arg  
    1205                 1210 


<210>  1294
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1294

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Lys Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Val Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Lys Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Phe Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Cys Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Lys Leu Asn Asp Glu 
        275                 280                 285             


Asn Ile Lys Tyr Val Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Ile Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Leu Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Asn Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Lys Ile Leu Lys Tyr Thr Glu Ser Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Ala Phe Ser Asp Gln Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Glu Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Lys 
        915                 920                 925             


Lys Tyr Glu Lys Ala Ile Arg Asn Ile Gln Gln Tyr Thr His Leu Lys 
    930                 935                 940                 


Asn Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Ser Leu Leu Leu 
945                 950                 955                 960 


Arg Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp 
                965                 970                 975     


Leu Arg Phe Arg Leu Lys Gly Glu Phe Pro Glu Asn Gln Tyr Ile His 
            980                 985                 990         


Glu Ile Phe Asn Phe Asp Asn Ser  Lys Asn Val Lys Tyr  Lys Asn Gly 
        995                 1000                 1005             


Gln Ile  Val Glu Lys Tyr Ile  Ser Phe Tyr Lys Glu  Leu Tyr Lys 
    1010                 1015                 1020             


Asp Asp  Met Glu Lys Ile Ser  Ile Tyr Ser Asp Lys  Lys Val Lys 
    1025                 1030                 1035             


Glu Leu  Lys Lys Glu Lys Lys  Asp Leu Tyr Ile Arg  Asn Tyr Ile 
    1040                 1045                 1050             


Ala His  Phe Asn Tyr Ile Pro  His Ala Glu Ile Ser  Leu Leu Glu 
    1055                 1060                 1065             


Val Leu  Glu Asn Leu Arg Lys  Leu Leu Ser Tyr Asp  Arg Lys Leu 
    1070                 1075                 1080             


Lys Asn  Ala Val Met Lys Ser  Val Val Asp Ile Leu  Lys Glu Tyr 
    1085                 1090                 1095             


Gly Phe  Val Ala Thr Phe Lys  Ile Gly Ala Asp Lys  Lys Ile Gly 
    1100                 1105                 1110             


Ile Gln  Thr Leu Glu Ser Glu  Lys Ile Val His Leu  Lys Asn Leu 
    1115                 1120                 1125             


Lys Lys  Lys Lys Leu Met Thr  Asp Arg Asn Ser Glu  Glu Leu Cys 
    1130                 1135                 1140             


Glu Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Lys  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  1295
<211>  1000
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1295

Val Thr Leu Tyr Phe Thr Thr Phe Arg Ile Phe Lys Lys His Tyr Lys 
1               5                   10                  15      


Val Asn Phe Asp Ser Lys Lys Phe Ser Asn Lys Ser Asp Glu Glu Lys 
            20                  25                  30          


Glu Leu Tyr Lys Ile Ile Tyr Arg Tyr Leu Lys Gly Arg Ile Glu Lys 
        35                  40                  45              


Ile Leu Ile Asn Gly Glu Lys Val Arg Leu Lys Lys Met Glu Lys Ile 
    50                  55                  60                  


Glu Ile Glu Lys Ile Leu Asn Glu Ser Ile Leu Ser Glu Lys Ile Leu 
65                  70                  75                  80  


Lys Arg Ile Lys Gln Tyr Thr Leu Glu His Ile Met Tyr Leu Gly Lys 
                85                  90                  95      


Leu Val His Asn Lys Ile Asn Met Ala Thr Val Asn Thr Asn Asp Phe 
            100                 105                 110         


Phe Arg Leu His Ala Lys Glu Glu Leu Asp Leu Glu Leu Ile Thr Phe 
        115                 120                 125             


Phe Ala Ser Thr Asn Met Glu Leu Asn Lys Ile Phe Asn Gly Lys Glu 
    130                 135                 140                 


Lys Ile Thr Asp Phe Phe Gly Phe Asn Leu Asn Gly Gln Lys Ile Thr 
145                 150                 155                 160 


Leu Lys Glu Lys Val Pro Asn Phe Lys Leu Asn Ile Leu Lys Lys Leu 
                165                 170                 175     


Asn Phe Ile Asn Asn Glu Asn Asn Ile Asp Glu Lys Leu Ser His Phe 
            180                 185                 190         


Tyr Ser Phe Gln Lys Glu Gly Tyr Leu Leu Arg Asn Arg Ile Leu His 
        195                 200                 205             


Asn Ser Tyr Glu Asn Ile Gln Glu Thr Lys Asn Leu Glu Gly Glu Tyr 
    210                 215                 220                 


Glu Asn Val Glu Asn Leu Ile Lys Lys Leu Lys Val Asn Asp Glu Glu 
225                 230                 235                 240 


Ile Ser Lys Ser Leu Asn Leu Asp Ile Ile Phe Glu Gly Lys Ala Gly 
                245                 250                 255     


Ile Ile Asn Lys Ile Asn Asn Leu Lys Ile Gly Glu Tyr Lys Asp Lys 
            260                 265                 270         


Lys Tyr Leu Pro Ser Phe Ser Lys Ile Val Pro Glu Ile Thr Arg Lys 
        275                 280                 285             


Phe Arg Glu Ile Asn Lys Asp Lys Ser Phe Asp Ile Glu Ser Glu Lys 
    290                 295                 300                 


Ile Ile Leu Asn Ala Val Gln Tyr Val Asn Lys Ile Leu Tyr Lys Lys 
305                 310                 315                 320 


Ile Thr Ser Asn Glu Glu Asn Glu Phe Ile Lys Thr Leu Pro Asp Lys 
                325                 330                 335     


Leu Val Lys Lys Asn Asn Asn Lys Glu Asn Lys Asn Ser Leu Ser Ile 
            340                 345                 350         


Glu Glu Tyr Tyr Lys Asn Ala Gln Ile Ser Ser Ser Lys Gly Asp Lys 
        355                 360                 365             


Lys Ala Ile Lys Lys Tyr Gln Asn Lys Val Thr Asn Ala Tyr Ile Glu 
    370                 375                 380                 


Tyr Leu Glu Asn Thr Phe Ala Glu Val Ile Asp Phe Ser Asn Phe Asn 
385                 390                 395                 400 


Leu Asn Phe Asp Glu Ile Lys Thr Lys Ile Glu Glu Arg Lys Tyr Ser 
                405                 410                 415     


Lys Ser Lys Ile Thr Val Asp Ser Ile Ser Thr Asn Ile Asn Ile Thr 
            420                 425                 430         


Asn Asp Ile Glu Tyr Ile Ile Ser Ile Phe Ala Leu Leu Asn Ser Asn 
        435                 440                 445             


Thr Tyr Ile Asn Lys Ile Arg Asn Arg Phe Phe Ala Thr Ser Val Trp 
    450                 455                 460                 


Leu Asn Thr Gln Lys Tyr Glu Asn Ile Ile Asp Ile Leu Asp Lys Ile 
465                 470                 475                 480 


Asp Ile Leu Asp Lys Ile Leu Ser Ile Asn Leu Leu Arg Glu Asn Asn 
                485                 490                 495     


Ile Ala Asp Ile Leu Asp Leu Lys Asn Thr Ile Ile Glu Ala Lys Ile 
            500                 505                 510         


Val Glu Asn Asn Glu Glu Cys Ile Lys Asn Tyr Ile Phe Glu Asn Asn 
        515                 520                 525             


Glu Glu Glu Leu Lys Lys Arg Leu Phe Cys Glu Glu Leu Ile Asn Lys 
    530                 535                 540                 


Glu Asp Val Leu Lys Ile Phe Glu Asp Lys Asn Phe Lys Phe Lys Asn 
545                 550                 555                 560 


Phe Ile Lys Lys Thr Gly Asn Glu Asn Phe Thr Ile Asp Phe Asp Ile 
                565                 570                 575     


Leu Phe Asn Leu Glu Cys Asn Ser Glu Leu Asn Ala Lys Lys Val Ile 
            580                 585                 590         


Gly Gln Asn Ser Gln Arg Leu Asn Leu Phe Ile Lys Asn Thr Ile Asp 
        595                 600                 605             


Glu Tyr Lys Ser Lys Ile Lys Thr Ser Phe Ser Ser Glu Phe Leu Glu 
    610                 615                 620                 


Lys Tyr Lys Lys Glu Ile Asp Asn Leu Val Glu Asp Thr Glu Ser Glu 
625                 630                 635                 640 


Asn Lys Asn Lys Phe Glu Lys Ile Tyr Tyr Pro Glu Glu His Lys Asn 
                645                 650                 655     


Glu Leu Tyr Ile Tyr Lys Lys Asn Leu Phe Leu Asn Ile Gly Asn Pro 
            660                 665                 670         


Asn Phe Asp Lys Ile Tyr Gly Leu Ile Ser Asn Asp Ile Lys Met Ala 
        675                 680                 685             


Asp Ala Lys Phe Leu Phe Asp Ser Asp Ser Lys Asp Ile Arg Asn Asn 
    690                 695                 700                 


Glu Ile Ser Lys Ile Asp Gly Ile Leu Lys Asn Leu Asn Asp Lys Leu 
705                 710                 715                 720 


Asn Gly Tyr Ser Lys Glu Tyr Lys Glu Lys Tyr Val Lys Lys Leu Lys 
                725                 730                 735     


Glu Ser Asn Asp Phe Phe Ala Lys Asn Ile Gln Asn Glu Asn Tyr Ser 
            740                 745                 750         


Ser Phe Glu Glu Phe Glu Lys Asn Tyr Asn Lys Ile Ser Glu Tyr Lys 
        755                 760                 765             


Lys Ile Arg Asp Leu Val Glu Phe Asn Tyr Leu Asn Lys Ile Glu Ser 
    770                 775                 780                 


Tyr Leu Ile Asp Ile Asn Trp Lys Leu Ala Ile Gln Met Ala Arg Phe 
785                 790                 795                 800 


Glu Arg Asp Met His Tyr Ile Val Asn Gly Leu Lys Lys Leu Asn Phe 
                805                 810                 815     


Ile Asn Leu Asn Gly Tyr Asn Thr Gly Ile Ser Arg Ala Tyr Pro Lys 
            820                 825                 830         


Tyr Asn Asp Thr Asp Ser Asn Lys Asn Cys Lys Lys Phe Tyr Glu Thr 
        835                 840                 845             


Thr Ala Tyr Tyr Lys Phe Phe Asp Asp Lys Ser Tyr Arg Glu Phe Glu 
    850                 855                 860                 


Asp Ile Cys Tyr Glu Phe Gly Ile Asp Leu Arg Lys Asn Ser Asn Ile 
865                 870                 875                 880 


Gln Ala Lys Glu Glu Arg Asn Ile Arg Asn Tyr Ile Ser His Phe Tyr 
                885                 890                 895     


Ile Val Arg Asn Pro Phe Val Asp Tyr Ser Ile Ala Glu Gln Ile Asp 
            900                 905                 910         


Arg Val Ser Asn Leu Leu Ser Tyr Ser Thr Arg Tyr Asn Asn Ser Thr 
        915                 920                 925             


Tyr Ala Ser Val Phe Glu Val Phe Lys Lys Asp Val Asp Leu Asp Tyr 
    930                 935                 940                 


Asp Glu Leu Lys Lys Lys Phe Lys Leu Ile Gly Asp Asn Asp Ile Leu 
945                 950                 955                 960 


Glu Lys Leu Met Lys Ser Lys Lys Val Ser Val Leu Glu Leu Glu Ser 
                965                 970                 975     


Tyr Asn Ser Asp Tyr Val Lys Asn Leu Ile Ile Lys Leu Leu Thr Lys 
            980                 985                 990         


Ile Glu Asn Thr Asn Asp Thr Leu  
        995                 1000 


<210>  1296
<211>  1075
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1296

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Asn Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Tyr Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Ala 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Asn Phe Tyr Glu Lys Asp Val Ile Ile Lys Tyr Leu Lys Asn Thr Lys 
    530                 535                 540                 


Phe Asn Phe Val Asn Lys Asn Ile Ser Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Asn Lys Ile Asp Asp Leu Arg Asn Thr Leu Lys Phe Ser Trp 
                565                 570                 575     


Lys Ile Pro Lys Asp Lys Glu Glu Lys Asp Ala Gln Ile Tyr Leu Leu 
            580                 585                 590         


Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn Lys Phe Val Lys Asn Ser 
        595                 600                 605             


Lys Asp Phe Phe Lys Ile Thr Asp Glu Val Ile Lys Ile Asn Lys Gln 
    610                 615                 620                 


Ile Asn Gln Lys Thr Gly Tyr Tyr Lys Tyr Gln Lys Phe Glu Asn Ile 
625                 630                 635                 640 


Glu Lys Thr Val Pro Val Glu Tyr Leu Ala Ile Ile Gln Ser Arg Asp 
                645                 650                 655     


Thr Ile Asn Asn Gln Asp Lys Glu Glu Lys Asn Thr Tyr Ile Asp Phe 
            660                 665                 670         


Val Gln Gln Ile Phe Leu Lys Gly Phe Ile Asp Tyr Leu Asn Lys Asn 
        675                 680                 685             


Asn Leu Lys Tyr Ile Glu Asn Asn Asn Asn Asn Asp Ile Phe Ser Arg 
    690                 695                 700                 


Ile Gln Ile Lys Lys Asp Ser Lys Glu Arg Tyr Asp Lys Ile Leu Lys 
705                 710                 715                 720 


Asn Tyr Glu Lys Asn Asn Arg Asn Lys Glu Ile Pro Tyr Glu Ile Asn 
                725                 730                 735     


Glu Phe Val Arg Glu Ile Lys Leu Gly Lys Ile Leu Lys Tyr Thr Glu 
            740                 745                 750         


Ser Leu Asn Met Phe Tyr Leu Ile Leu Lys Leu Leu Asn His Lys Glu 
        755                 760                 765             


Leu Thr Asn Leu Lys Gly Ser Leu Glu Lys Tyr Gln Ser Ala Asn Lys 
    770                 775                 780                 


Glu Glu Ala Phe Ser Asp Gln Leu Glu Leu Ile Asn Leu Leu Asn Leu 
785                 790                 795                 800 


Asp Asn Asn Arg Val Thr Glu Asp Phe Glu Leu Glu Ala Asp Glu Ile 
                805                 810                 815     


Gly Lys Phe Leu Asp Phe Asn Gly Asn Lys Val Lys Asp Arg Lys Glu 
            820                 825                 830         


Leu Lys Lys Phe Asp Thr Lys Lys Ile Tyr Phe Asp Gly Glu Asn Ile 
        835                 840                 845             


Ile Lys His Arg Ala Phe Tyr Asn Ile Lys Lys Tyr Gly Met Leu Asn 
    850                 855                 860                 


Leu Leu Glu Lys Ile Ser Asp Glu Ala Lys Tyr Lys Ile Ser Ile Glu 
865                 870                 875                 880 


Glu Leu Lys Asn Tyr Ser Asn Lys Lys Asn Glu Ile Glu Lys Asn His 
                885                 890                 895     


Thr Thr Gln Glu Asn Leu His Arg Lys Tyr Ala Arg Pro Arg Lys Asp 
            900                 905                 910         


Glu Lys Phe Thr Asp Glu Asp Tyr Lys Lys Tyr Glu Lys Ala Ile Arg 
        915                 920                 925             


Asn Ile Gln Gln Tyr Thr His Leu Lys Asn Lys Val Glu Phe Asn Glu 
    930                 935                 940                 


Leu Asn Leu Leu Gln Ser Leu Leu Leu Arg Ile Leu His Arg Leu Val 
945                 950                 955                 960 


Gly Tyr Thr Ser Ile Trp Glu Arg Asp Leu Arg Phe Arg Leu Lys Gly 
                965                 970                 975     


Glu Phe Pro Glu Asn Gln Tyr Ile Glu Glu Ile Phe Asn Phe Asp Asn 
            980                 985                 990         


Ser Lys Asn Val Lys Tyr Lys Asn  Gly Gln Ile Val Glu  Lys Tyr Ile 
        995                 1000                 1005             


Asn Phe  Tyr Lys Glu Leu Tyr  Lys Asp Asp Thr Glu  Lys Ile Ser 
    1010                 1015                 1020             


Ile Tyr  Ser Asp Lys Lys Val  Lys Glu Leu Lys Lys  Glu Lys Lys 
    1025                 1030                 1035             


Asp Leu  Tyr Ile Arg Asn Tyr  Ile Ala His Phe Asn  Tyr Ile Pro 
    1040                 1045                 1050             


His Ala  Glu Ile Ser Leu Leu  Glu Met Leu Glu Asn  Leu Arg Lys 
    1055                 1060                 1065             


Leu Leu  Ser Tyr Asp Arg Lys  
    1070                 1075 


<210>  1297
<211>  1169
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1297

Met Lys Ile Thr Lys Arg Lys Trp Glu Asp Val Pro Pro Leu Phe Phe 
1               5                   10                  15      


His Arg Asp Lys Asp Ser Gly Arg Leu Ile Arg Gln Asp Asp Arg Glu 
            20                  25                  30          


His Asp Tyr Thr Asp Glu Leu Phe Arg Lys Thr Thr Val Asp Ser Ile 
        35                  40                  45              


Phe Ile Arg Ser Leu Gln Asn Arg Leu Leu Arg Ser Gln Asp Lys Glu 
    50                  55                  60                  


Gly Asn Lys Ile Gly Arg Asn Glu Ile Thr Glu Leu Val Glu Asn Leu 
65                  70                  75                  80  


Cys Lys Gly Ala Glu Ile Gln Lys Ser Ile Asp Glu Ile Lys Asp Ser 
                85                  90                  95      


Lys Ser Asn Val Lys Ala Leu Cys Asp Lys Thr Leu Thr Asp Tyr Gly 
            100                 105                 110         


Lys Ser Phe Ala Ala Glu Glu Gly Arg Thr Thr Leu Tyr Glu Ala Ile 
        115                 120                 125             


Leu Asn Leu Ala Lys Gly Asn Ala Ile Gln Lys Ala Met Ala Glu Ala 
    130                 135                 140                 


Glu Leu Lys Gln Ile His Glu Ala Leu Lys Lys Glu Lys Glu Asp Arg 
145                 150                 155                 160 


Ile Asn Arg Val Gln Asn Ser Ile Lys Asn Asn Lys Ile Pro Leu Lys 
                165                 170                 175     


Val Asn Glu Asp Gly Thr Ile Ser Ala Asn Asn Asp Arg Ala Ser Trp 
            180                 185                 190         


Leu Leu Glu Leu Leu Lys Pro Val Ala Ser Glu His Asp Lys Gly Asp 
        195                 200                 205             


Arg Tyr Pro Val Leu Thr Glu Met Glu Gly Ile Val Ser Phe Asp Lys 
    210                 215                 220                 


Leu Cys Glu Glu Val Arg Asn Lys Ile His Gly Arg Lys Gly Arg Thr 
225                 230                 235                 240 


Arg Ser Ile Ala Met Ser Val Asp Glu Ala Val Lys Glu Tyr Leu Lys 
                245                 250                 255     


Glu Leu Trp Lys Lys His Ala Asp Arg His Arg Asp Met Arg Tyr Tyr 
            260                 265                 270         


Phe Gln Ala Val Lys Glu Tyr Phe Lys Glu Asn Phe Pro Ile Arg Thr 
        275                 280                 285             


Lys Gln Lys Gly Ala Gly Ile Arg Gln Ser Leu Leu Lys Glu Asp Thr 
    290                 295                 300                 


Val Val Ala Arg Leu Leu Asp Pro Lys His Met Ala Lys Ala Val Arg 
305                 310                 315                 320 


Arg Lys Leu Ile Asn Gln Ser Thr Gln Met His Ile Leu Tyr Gly Lys 
                325                 330                 335     


Leu Tyr Glu Tyr Cys Cys Arg Glu Asp Arg Asn Leu Pro Val Asn Ser 
            340                 345                 350         


Glu Thr Leu Gln Leu Ile Gln Val Leu Glu Ala Val Lys Lys Gln Leu 
        355                 360                 365             


Met Thr Ala Val Leu Trp Ser Val Ser Arg Leu Cys Tyr Phe Tyr Glu 
    370                 375                 380                 


Phe Tyr Ser Gly Asp Ile Leu Leu Ala Glu Glu Tyr Arg Arg Asp Phe 
385                 390                 395                 400 


Leu Asn Gln Lys Asn Asp His Lys Asp Ile Gln Ala Cys Lys Glu Lys 
                405                 410                 415     


Leu Gln Asp Phe Phe Pro Leu Ala Glu Leu Gln Glu Lys Ile Arg Glu 
            420                 425                 430         


Cys Ala Asp Lys Asp Ile Asn Asn Ile Lys Asp Lys Ile Thr Asn Asp 
        435                 440                 445             


Val Leu Ala Cys Asn Asn Leu Leu Glu Glu Cys Val Phe Cys Ile Ser 
    450                 455                 460                 


Lys Leu Arg Asn Asn Ile Phe His Tyr Lys Asn Leu Ser Phe Thr Gln 
465                 470                 475                 480 


Ala Leu Lys His Ile Ala Asn Glu Ile Lys Glu Glu Asp Ile Pro Ile 
                485                 490                 495     


Ile Leu Arg Leu Tyr Lys Gln Asp Cys Glu Asn Val Asn Lys Ala Phe 
            500                 505                 510         


Ala Asn Arg Ile Ser Ser Met Asn Leu Pro Leu Tyr Tyr Ser Thr Glu 
        515                 520                 525             


Phe Leu Leu Arg Ile Phe Lys Lys Gln Gly Ala Glu Leu Ser Leu Tyr 
    530                 535                 540                 


Ser Thr Lys Asn Gln Met Thr Pro Ser Phe Lys Arg Val Tyr Glu Arg 
545                 550                 555                 560 


Gly Lys Asn Leu Arg Leu Glu Tyr Glu Arg Glu Pro Met Arg Ser Asn 
                565                 570                 575     


Ile Ala Asn Glu Tyr Asp Lys Asp Pro Gln Ser Asp Tyr Trp Met Arg 
            580                 585                 590         


Trp Phe Ser Gln Phe Ala Thr Gly Thr Val Asp Thr Asn Ala Gly Ile 
        595                 600                 605             


Lys Gly Glu Met Glu Asp Tyr Pro His Ala Ser Val Asn Leu Gly Ile 
    610                 615                 620                 


Glu Ile Glu Ala Gly Thr Asn Ile Asp Ala Gln Arg Ala Met Arg Asn 
625                 630                 635                 640 


Leu Leu Gln Leu Ile Tyr Lys His His Phe Leu Pro Glu Val Gln Lys 
                645                 650                 655     


Asp Glu Thr Val Val Thr Asp Val Ile Pro Lys Val Leu Glu Arg Asn 
            660                 665                 670         


Arg Lys Leu Ser Glu Val Arg Asn Arg Ser Asp Lys Thr Tyr Gly Tyr 
        675                 680                 685             


Lys Glu Ile Glu Glu Leu Cys Lys Lys Asn Lys Gly Lys Lys Asp Ser 
    690                 695                 700                 


Leu Ser Glu Leu Met Lys Asp Leu Gln Arg Lys Val Ser Glu Thr Glu 
705                 710                 715                 720 


Lys Glu Lys Arg Glu Leu Ala Arg Glu Lys Thr Asp Tyr Ala Gln Arg 
                725                 730                 735     


Phe Ile Leu Asp Ile Phe Ala Glu Ala Phe Cys Asn Phe Met Asp Glu 
            740                 745                 750         


Arg Tyr Glu Asp Glu Tyr Gln Glu Ile Met Ser Pro Ile Lys Asn Glu 
        755                 760                 765             


Glu Glu Ala Lys Lys Trp Thr Glu Met Phe Thr Asp Lys Ala Asp Lys 
    770                 775                 780                 


Asp Asn Lys Asp Lys Leu Leu Val Leu Lys Thr Ser Phe Asp Lys Asp 
785                 790                 795                 800 


Asn Val Glu Lys Tyr Leu Leu Val Leu Tyr Pro Leu Met Arg Leu Leu 
                805                 810                 815     


Asp Asp Lys Glu Leu Ser Glu Leu Gln Gln Gln Met Leu Arg Phe Arg 
            820                 825                 830         


Ala Ser Val Ser Gly Trp Gln Gly Gly Thr Asp Phe Ser Glu Asp Ile 
        835                 840                 845             


Ala Met Ala Glu Lys Ile Glu Glu Leu Ala Glu Leu Val Lys Leu Thr 
    850                 855                 860                 


Glu Pro Glu Ser Gln Tyr Ala Glu Glu Ala Trp Lys Asn Arg Ala Ile 
865                 870                 875                 880 


Gly Val Phe Glu Gln Phe Val Glu Gly Lys Met Ala Glu Tyr Gly Thr 
                885                 890                 895     


Phe Tyr Ile Gln Asn Asp Ser Leu Thr Gln Val Pro Arg Gly Asn Met 
            900                 905                 910         


Arg Lys Leu Leu Arg Ser Gly Val Ile Gly Val Tyr Asn Lys Val Leu 
        915                 920                 925             


Ala Ser Cys Lys Gln Ala Thr Lys Ala Asp Tyr Gly Ala Tyr Ser Gly 
    930                 935                 940                 


Asp His Trp Ser Ile Glu Asp Pro Asp Gly Asn Pro Ile Lys Ser Ala 
945                 950                 955                 960 


Glu Gln Ala Gln Ala Leu Leu Gln Arg Leu His Lys Lys Tyr Thr Glu 
                965                 970                 975     


Ser Pro Ser Gln Phe Ser Asp Asp Asp His Lys Leu Tyr Asp Lys Thr 
            980                 985                 990         


Leu Arg Gln Leu Asp Ala Tyr Asn  Arg Ala Met Lys Asn  Leu Ser Phe 
        995                 1000                 1005             


Gly Ser  Leu Tyr Glu Ile Cys  Arg Ile His Met Glu  Thr Leu Ser 
    1010                 1015                 1020             


Arg Trp  Val Gly Phe Val Gln  Asp Trp Glu Arg Asp  Met Tyr Phe 
    1025                 1030                 1035             


Leu Leu  Leu Ala Trp Thr Lys  Gln Gly Lys Leu Leu  Asn Val Thr 
    1040                 1045                 1050             


Glu Thr  Asp Val Ile Glu Ile  Phe Glu Lys Gly Ser  Val Ile Tyr 
    1055                 1060                 1065             


Lys Met  Asn Lys Lys Leu Lys  Asn Gly Asp Arg Tyr  Ala Phe Thr 
    1070                 1075                 1080             


Ser Ile  Tyr Arg Asn Asn Asn  Asp Glu Lys Leu Glu  Phe Leu Gln 
    1085                 1090                 1095             


Ile Arg  Asn Phe Ile Ala His  Leu His Leu Leu Arg  Lys Ser Glu 
    1100                 1105                 1110             


Trp Lys  Gly Asp Lys Lys Ala  Gly Tyr Ser Val Ile  Glu Asp Tyr 
    1115                 1120                 1125             


Ile Asn  Lys Leu Arg Phe Leu  Leu Ser Tyr Asp Gln  Lys Arg Met 
    1130                 1135                 1140             


Asn Ala  Val Thr Lys Ala Met  Gln Gln Ile Phe Glu  Lys His Lys 
    1145                 1150                 1155             


Val Ile  Val Lys Phe Met Val  Glu Lys Gly Gly 
    1160                 1165                 


<210>  1298
<211>  1038
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1298

Leu Lys Trp Arg Lys Asn Met Lys Leu Ser Lys Val Thr Tyr Arg Val 
1               5                   10                  15      


Lys Asp Lys Asn Ala Lys Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala 
            20                  25                  30          


Val Ala Asn Asn Ser Glu Asn Ala Gly Gly Val Leu Tyr His Val Pro 
        35                  40                  45              


Gly Val Asp Leu Ile Asp Leu Lys Glu Gln Met Leu Asp Arg Asp Arg 
    50                  55                  60                  


Ser Val Arg Leu Leu Tyr Asn Ile Phe Asn Gln Ile Gln Thr Gly Thr 
65                  70                  75                  80  


Lys Pro Lys Lys Trp Gly Asn Asp Glu Thr Leu Ser Val Asp Glu Asn 
                85                  90                  95      


Glu Arg Lys Ala Lys Glu Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp 
            100                 105                 110         


Arg Glu Ala Cys Ser Glu Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn 
        115                 120                 125             


Ser Val Leu Phe Tyr Ser Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg 
    130                 135                 140                 


Met Asn Asp Asn Glu Ala Ile Ile Val Lys Met Gln Tyr Glu Asn Arg 
145                 150                 155                 160 


Leu Ser His Phe Thr Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr 
                165                 170                 175     


Leu Arg Asn Ser Leu Val Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp 
            180                 185                 190         


Ser Val Asn Ala Met Val Val Phe Ile Asn Asn Ile Gly Asn Gly Asn 
        195                 200                 205             


Ile Ser Asp Lys Asp Lys Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile 
    210                 215                 220                 


Arg Asn Asp Phe Ser Lys Leu Asn Pro Asn Val Gln Ser Ser Gln Gly 
225                 230                 235                 240 


Ala Asn Met Val Arg Ser Val Arg Asn Gln Asn Met Val Val Gln Pro 
                245                 250                 255     


Gln Gly Asp Ile Val Ser Phe Pro Leu Val Ser Asp Glu Gly Lys Asn 
            260                 265                 270         


Thr Val Thr Asn Lys Asn Val Glu Lys Lys Gly Leu Asn Glu Phe Leu 
        275                 280                 285             


Leu Asn Tyr Ala Asn Leu Asp Asp Glu Glu Arg Met Glu Asn Leu Arg 
    290                 295                 300                 


Lys Leu Arg Arg Ile Ile Asp Val Tyr Phe Ser Ser Pro Ser His Tyr 
305                 310                 315                 320 


Gln Lys Asp Met Asp Ile Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys 
                325                 330                 335     


Phe Val Val Trp Lys Lys His Glu Thr Gly Lys Lys Asn Thr Glu Leu 
            340                 345                 350         


Phe Val Asp Ile Pro Asp Glu Leu Phe Thr Ala Glu Thr Glu Lys Ile 
        355                 360                 365             


Lys Leu Asp Ala Val Leu Glu Lys Gln Ala Arg Lys Arg Leu Thr Asp 
    370                 375                 380                 


Ser Ile Arg Lys Gln Asn Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val 
385                 390                 395                 400 


Val Glu Lys Tyr Asn Ser Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser 
                405                 410                 415     


Ile Asn Gln Tyr Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile 
            420                 425                 430         


Leu Lys Ser Cys Lys Ala Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr 
        435                 440                 445             


Leu Thr Glu Lys Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys 
    450                 455                 460                 


Tyr Ile Ala Leu Gly Lys Val Ile Tyr Asn Phe Thr Val Asp Asp Ile 
465                 470                 475                 480 


Trp Lys Asp Lys Lys Val Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile 
                485                 490                 495     


Lys His Gly Ile Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu 
            500                 505                 510         


Ala Leu Gln Arg Glu Leu Ala Val Asn Val Ala Phe Ala Ala Asn Asn 
        515                 520                 525             


Leu Ala Arg Ala Val Cys Asp Met Thr Asn Leu Lys Asp Lys Glu Ser 
    530                 535                 540                 


Asp Phe Leu Ile Trp Asn Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn 
545                 550                 555                 560 


Lys Asp Asp Met Ala Ser Val Ser Val Val Leu Gln Phe Phe Gly Gly 
                565                 570                 575     


Lys Ser Ser Trp Asp Ile Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn 
            580                 585                 590         


Lys Tyr Asn Tyr Glu Val Cys Phe Ile Asp Asp Leu Arg Lys Ala Val 
        595                 600                 605             


Tyr Ala Ala Arg Asn Glu Ser Phe His Phe Lys Thr Ala Leu Val Asn 
    610                 615                 620                 


Asn Asp Ile Trp Asn Thr Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu 
625                 630                 635                 640 


Thr Glu Ile Cys Leu Asp Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn 
                645                 650                 655     


Leu Pro Val Phe Tyr Ser Asp Asn Asp Leu Lys Lys Met Leu Asp His 
            660                 665                 670         


Leu Tyr Asn Asn Lys Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn 
        675                 680                 685             


Ser Val Met Val Arg Lys Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu 
    690                 695                 700                 


Lys Tyr Gln Lys Pro Gly Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr 
705                 710                 715                 720 


Ser Ala Cys Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu 
                725                 730                 735     


Gln Ser Asp Glu Ala Leu Ala Leu Phe Glu Glu Ser Val Asn Asn Leu 
            740                 745                 750         


Lys Gly Asp Asn Lys Asp Gln Glu Leu Ala Val Lys Asn Phe Arg Asn 
        755                 760                 765             


Asn Tyr Lys Asn Ile Lys Ser Ser Cys Thr Ser Phe Ser Gln Val Cys 
    770                 775                 780                 


Gln Met Tyr Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys 
785                 790                 795                 800 


Val Arg Ser Ser Lys Asp Ser Ile Val Asp Lys Pro Ile Tyr Gln His 
                805                 810                 815     


Tyr Lys Leu Leu Leu Lys Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr 
            820                 825                 830         


Leu Gln His Asn Lys Glu Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys 
        835                 840                 845             


Val Asn Cys Leu Lys Glu Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp 
    850                 855                 860                 


Thr Ala Lys Lys Tyr Val Ser Leu Cys Glu Glu Val Arg Lys Ser Pro 
865                 870                 875                 880 


Glu Leu Gln Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ser Arg Ser 
                885                 890                 895     


Leu Asn Leu Met Ala Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Asn 
            900                 905                 910         


Asp Ile Lys Arg Arg Ala Asp Gly Ile Gly Asn Glu Leu His Val Ile 
        915                 920                 925             


Ala Gln Asn Leu Asp Val Val Asp Lys Trp Val Gln Val Ile Glu Val 
    930                 935                 940                 


Cys Leu Leu Leu Ser Ser Arg Val Ser Asn Glu Phe Glu Asp Tyr Phe 
945                 950                 955                 960 


Tyr Asp Lys Asp Asp Tyr Ala Ala Tyr Leu Lys Ser Tyr Val Asp Phe 
                965                 970                 975     


Asp Asn Ser Asp Met Pro Ser Glu Tyr Ser Ala Leu Val Glu Phe Ser 
            980                 985                 990         


Asp Gln Gly Lys Val Asp Leu Tyr  Val Asp Pro Ser Asn  Pro Lys Val 
        995                 1000                 1005             


Asn Arg  Asn Ile Val Gln Ser  Lys Leu Phe Ala Ala  Asp Tyr Ile 
    1010                 1015                 1020             


Leu Arg  Asp Ile Ile Glu Pro  Val Ser Lys Asp Glu  Ile Glu Asp 
    1025                 1030                 1035             


<210>  1299
<211>  1169
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1299

Met Lys Ile Thr Lys Arg Lys Trp Glu Asp Val Pro Pro Leu Phe Phe 
1               5                   10                  15      


His Arg Asp Lys Asp Ser Gly Arg Leu Ile Arg Gln Asp Asp Arg Glu 
            20                  25                  30          


His Asp Tyr Thr Asp Glu Leu Phe Arg Lys Thr Thr Val Asp Ser Ile 
        35                  40                  45              


Phe Ile Arg Ser Leu Gln Asn Arg Leu Leu Arg Ser Gln Asp Lys Glu 
    50                  55                  60                  


Gly Asn Lys Ile Gly Arg Asn Glu Ile Thr Glu Leu Val Glu Asn Leu 
65                  70                  75                  80  


Cys Lys Gly Ala Glu Ile Gln Lys Ser Ile Asp Glu Ile Lys Asp Ser 
                85                  90                  95      


Lys Ser Asn Val Lys Ala Leu Cys Asp Lys Thr Leu Thr Asp Tyr Gly 
            100                 105                 110         


Lys Ser Phe Ala Ala Glu Glu Gly Arg Thr Thr Leu Tyr Glu Ala Ile 
        115                 120                 125             


Leu Asn Leu Ala Lys Gly Asn Ala Ile Gln Lys Ala Met Ala Glu Ala 
    130                 135                 140                 


Glu Leu Lys Gln Ile His Glu Ala Leu Lys Lys Glu Lys Glu Asp Arg 
145                 150                 155                 160 


Ile Asn Arg Val Gln Asn Ser Ile Lys Asn Asn Lys Ile Pro Leu Lys 
                165                 170                 175     


Val Asn Glu Asp Gly Thr Ile Ser Ala Asn Asn Asp Arg Ala Ser Trp 
            180                 185                 190         


Leu Leu Glu Leu Leu Lys Pro Val Ala Ser Glu His Asp Lys Gly Asp 
        195                 200                 205             


Arg Tyr Pro Val Leu Thr Glu Met Glu Gly Ile Val Ser Phe Asp Lys 
    210                 215                 220                 


Leu Cys Glu Glu Val Arg Asn Lys Ile His Gly Arg Lys Gly Arg Thr 
225                 230                 235                 240 


Arg Ser Ile Ala Met Ser Val Asp Glu Ala Val Lys Glu Tyr Leu Lys 
                245                 250                 255     


Glu Leu Trp Lys Lys His Ala Asp Arg His Arg Asp Met Arg Tyr Tyr 
            260                 265                 270         


Phe Gln Ala Val Lys Glu Tyr Phe Lys Glu Asn Phe Pro Ile Arg Thr 
        275                 280                 285             


Lys Gln Lys Gly Ala Gly Ile Arg Gln Ser Leu Leu Lys Glu Asp Thr 
    290                 295                 300                 


Val Val Ala Arg Leu Leu Asp Pro Lys His Met Ala Lys Ala Val Arg 
305                 310                 315                 320 


Arg Lys Leu Ile Asn Gln Ser Thr Gln Met His Ile Leu Tyr Gly Lys 
                325                 330                 335     


Leu Tyr Glu Tyr Cys Cys Arg Glu Asp Arg Asn Leu Pro Val Asn Ser 
            340                 345                 350         


Glu Thr Leu Gln Leu Ile Gln Val Leu Glu Ala Val Lys Lys Gln Leu 
        355                 360                 365             


Met Thr Ala Val Leu Trp Ser Val Ser Arg Leu Cys Tyr Phe Tyr Glu 
    370                 375                 380                 


Phe Tyr Ser Gly Asp Ile Leu Leu Ala Glu Glu Tyr Arg Arg Asp Phe 
385                 390                 395                 400 


Leu Asn Gln Lys Asn Asp His Lys Asp Ile Gln Ala Cys Lys Glu Lys 
                405                 410                 415     


Leu Gln Asp Phe Phe Pro Leu Ala Glu Leu Gln Glu Lys Ile Arg Glu 
            420                 425                 430         


Cys Ala Asp Lys Asp Ile Asn Asn Ile Lys Asp Lys Ile Thr Asn Asp 
        435                 440                 445             


Val Leu Ala Cys Asn Asn Leu Leu Glu Glu Cys Val Phe Cys Ile Ser 
    450                 455                 460                 


Lys Leu Arg Asn Asn Ile Phe His Tyr Lys Asn Leu Ser Phe Thr Gln 
465                 470                 475                 480 


Ala Leu Lys His Ile Ala Asn Glu Ile Lys Glu Glu Asp Ile Pro Ile 
                485                 490                 495     


Ile Leu Arg Leu Tyr Lys Gln Asp Cys Glu Asn Val Asn Lys Ala Phe 
            500                 505                 510         


Ala Asn Arg Ile Ser Ser Met Asn Leu Pro Leu Tyr Tyr Ser Thr Glu 
        515                 520                 525             


Phe Leu Leu Arg Ile Phe Lys Lys Gln Gly Ala Glu Leu Ser Leu Tyr 
    530                 535                 540                 


Ser Thr Lys Asn Gln Met Thr Pro Ser Phe Lys Arg Val Tyr Glu Arg 
545                 550                 555                 560 


Gly Lys Asn Leu Arg Leu Glu Tyr Glu Arg Glu Pro Met Arg Ser Asn 
                565                 570                 575     


Ile Ala Asn Glu Tyr Asp Lys Asp Pro Gln Ser Asp Tyr Trp Met Arg 
            580                 585                 590         


Trp Phe Ser Gln Phe Ala Thr Gly Thr Val Asp Thr Asn Ala Gly Ile 
        595                 600                 605             


Lys Gly Glu Met Glu Asp Tyr Pro His Ala Ser Val Asn Leu Gly Ile 
    610                 615                 620                 


Glu Ile Glu Ala Gly Thr Asn Ile Asp Ala Gln Arg Ala Met Arg Asn 
625                 630                 635                 640 


Leu Leu Gln Leu Ile Tyr Lys His His Phe Leu Pro Glu Val Gln Lys 
                645                 650                 655     


Asp Glu Thr Val Val Thr Asp Val Ile Pro Lys Val Leu Glu Arg Asn 
            660                 665                 670         


Arg Lys Leu Ser Glu Val Arg Asn Arg Ser Asp Lys Thr Tyr Gly Tyr 
        675                 680                 685             


Lys Glu Ile Glu Glu Leu Cys Lys Lys Asn Lys Gly Lys Lys Asp Ser 
    690                 695                 700                 


Leu Ser Glu Leu Met Lys Asp Leu Gln Arg Lys Val Ser Glu Thr Glu 
705                 710                 715                 720 


Lys Glu Lys Arg Glu Leu Ala Arg Glu Lys Thr Asp Tyr Ala Gln Arg 
                725                 730                 735     


Phe Ile Leu Asp Ile Phe Ala Glu Ala Phe Cys Asn Phe Met Asp Glu 
            740                 745                 750         


Arg Tyr Glu Asp Glu Tyr Gln Glu Ile Met Ser Pro Ile Lys Asn Glu 
        755                 760                 765             


Glu Glu Ala Lys Lys Trp Thr Glu Met Phe Thr Asp Lys Ala Asp Lys 
    770                 775                 780                 


Asp Asn Lys Asp Lys Leu Leu Val Leu Lys Thr Ser Phe Asp Lys Asp 
785                 790                 795                 800 


Asn Val Glu Lys Tyr Leu Leu Val Leu Tyr Pro Leu Met Arg Leu Leu 
                805                 810                 815     


Asp Asp Lys Glu Leu Ser Glu Leu Gln Gln Gln Met Leu Arg Phe Arg 
            820                 825                 830         


Ala Ser Val Ser Gly Trp Gln Gly Gly Thr Asp Phe Ser Glu Asp Ile 
        835                 840                 845             


Ala Met Ala Glu Lys Ile Glu Glu Leu Ala Glu Leu Val Lys Leu Thr 
    850                 855                 860                 


Glu Pro Glu Ser Gln Tyr Ala Glu Glu Ala Trp Lys Asn Arg Ala Ile 
865                 870                 875                 880 


Gly Val Phe Glu Gln Phe Val Glu Gly Lys Met Ala Glu Tyr Gly Thr 
                885                 890                 895     


Phe Tyr Ile Gln Asn Asp Ser Leu Thr Gln Val Pro Arg Gly Asn Met 
            900                 905                 910         


Arg Lys Leu Leu Arg Ser Gly Val Ile Gly Val Tyr Asn Lys Val Leu 
        915                 920                 925             


Ala Ser Cys Lys Gln Ala Thr Lys Ala Asp Tyr Gly Ala Tyr Ser Gly 
    930                 935                 940                 


Asp His Trp Ser Ile Glu Asp Pro Asp Gly Asn Pro Ile Lys Ser Ala 
945                 950                 955                 960 


Glu Gln Ala Gln Ala Leu Leu Gln Arg Leu His Lys Lys Tyr Thr Glu 
                965                 970                 975     


Ser Pro Ser Gln Phe Ser Asp Asp Asp His Lys Leu Tyr Asp Lys Thr 
            980                 985                 990         


Leu Arg Gln Leu Asp Ala Tyr Asn  Arg Ala Met Lys Asn  Leu Ser Phe 
        995                 1000                 1005             


Gly Ser  Leu Tyr Glu Ile Cys  Arg Ile His Met Glu  Thr Leu Ser 
    1010                 1015                 1020             


Arg Trp  Val Gly Phe Val Gln  Asp Trp Glu Arg Asp  Met Tyr Phe 
    1025                 1030                 1035             


Leu Leu  Leu Ala Trp Thr Lys  Gln Gly Lys Leu Leu  Asn Val Thr 
    1040                 1045                 1050             


Glu Thr  Asp Val Ile Glu Ile  Phe Glu Lys Gly Ser  Val Ile Tyr 
    1055                 1060                 1065             


Lys Met  Asn Lys Lys Leu Lys  Asn Gly Asp Arg Tyr  Ala Phe Thr 
    1070                 1075                 1080             


Ser Ile  Tyr Arg Asn Asn Asn  Asp Glu Lys Leu Glu  Phe Leu Gln 
    1085                 1090                 1095             


Ile Arg  Asn Phe Ile Ala His  Leu His Leu Leu Arg  Lys Ser Glu 
    1100                 1105                 1110             


Trp Lys  Gly Asp Lys Lys Ala  Gly Tyr Ser Val Ile  Glu Asp Tyr 
    1115                 1120                 1125             


Ile Asn  Lys Leu Arg Phe Leu  Leu Ser Tyr Asp Gln  Lys Arg Met 
    1130                 1135                 1140             


Asn Ala  Val Thr Lys Ala Met  Gln Gln Ile Phe Glu  Lys His Lys 
    1145                 1150                 1155             


Val Ile  Val Lys Phe Met Val  Glu Lys Gly Gly 
    1160                 1165                 


<210>  1300
<211>  1169
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1300

Met Lys Ile Thr Lys Arg Lys Trp Glu Asp Val Pro Pro Leu Phe Phe 
1               5                   10                  15      


His Arg Asp Lys Asp Ser Gly Arg Leu Ile Arg Gln Asp Asp Arg Glu 
            20                  25                  30          


His Asp Tyr Thr Asp Glu Leu Phe Arg Lys Thr Thr Val Asp Ser Ile 
        35                  40                  45              


Phe Ile Arg Ser Leu Gln Asn Arg Leu Leu Arg Ser Gln Asp Lys Glu 
    50                  55                  60                  


Gly Asn Lys Ile Gly Arg Asn Glu Ile Thr Glu Leu Val Glu Asn Leu 
65                  70                  75                  80  


Cys Lys Gly Ala Glu Ile Gln Lys Ser Ile Asp Glu Ile Lys Asp Ser 
                85                  90                  95      


Lys Ser Asn Val Lys Ala Leu Cys Asp Lys Thr Leu Thr Asp Tyr Gly 
            100                 105                 110         


Lys Ser Phe Ala Ala Glu Glu Gly Arg Thr Thr Leu Tyr Glu Ala Ile 
        115                 120                 125             


Leu Asn Leu Ala Lys Gly Asn Ala Ile Gln Lys Ala Met Ala Glu Ala 
    130                 135                 140                 


Glu Leu Lys Gln Ile His Glu Ala Leu Lys Lys Glu Lys Glu Asp Arg 
145                 150                 155                 160 


Ile Asn Arg Val Gln Asn Ser Ile Lys Asn Asn Lys Ile Pro Leu Lys 
                165                 170                 175     


Val Asn Glu Asp Gly Thr Ile Ser Ala Asn Asn Asp Arg Ala Ser Trp 
            180                 185                 190         


Leu Leu Glu Leu Leu Lys Pro Val Ala Ser Glu His Asp Lys Gly Asp 
        195                 200                 205             


Arg Tyr Pro Val Leu Thr Glu Met Glu Gly Ile Val Ser Phe Asp Lys 
    210                 215                 220                 


Leu Cys Glu Glu Val Arg Asn Lys Ile His Gly Arg Lys Gly Arg Thr 
225                 230                 235                 240 


Arg Ser Ile Ala Met Ser Val Asp Glu Ala Val Lys Glu Tyr Leu Lys 
                245                 250                 255     


Glu Leu Trp Lys Lys His Ala Asp Arg His Arg Asp Met Arg Tyr Tyr 
            260                 265                 270         


Phe Gln Ala Val Lys Glu Tyr Phe Lys Glu Asn Phe Pro Ile Arg Thr 
        275                 280                 285             


Lys Gln Lys Gly Ala Gly Ile Arg Gln Ser Leu Leu Lys Glu Asp Thr 
    290                 295                 300                 


Val Val Ala Arg Leu Leu Asp Pro Lys His Met Ala Lys Ala Val Arg 
305                 310                 315                 320 


Arg Lys Leu Ile Asn Gln Ser Thr Gln Met His Ile Leu Tyr Gly Lys 
                325                 330                 335     


Leu Tyr Glu Tyr Cys Cys Arg Glu Asp Arg Asn Leu Pro Val Asn Ser 
            340                 345                 350         


Glu Thr Leu Gln Leu Ile Gln Val Leu Glu Ala Val Lys Lys Gln Leu 
        355                 360                 365             


Met Thr Ala Val Leu Trp Ser Val Ser Arg Leu Cys Tyr Phe Tyr Glu 
    370                 375                 380                 


Phe Tyr Ser Gly Asp Ile Leu Leu Ala Glu Glu Tyr Arg Arg Asp Phe 
385                 390                 395                 400 


Leu Asn Gln Lys Asn Asp His Lys Asp Ile Gln Ala Cys Lys Glu Lys 
                405                 410                 415     


Leu Gln Asp Phe Phe Pro Leu Ala Glu Leu Gln Glu Lys Ile Arg Glu 
            420                 425                 430         


Cys Ala Asp Lys Asp Ile Asn Asn Ile Lys Asp Lys Ile Thr Asn Asp 
        435                 440                 445             


Val Leu Ala Cys Asn Asn Leu Leu Glu Glu Cys Val Phe Cys Ile Ser 
    450                 455                 460                 


Lys Leu Arg Asn Asn Ile Phe His Tyr Lys Asn Leu Ser Phe Thr Gln 
465                 470                 475                 480 


Ala Leu Lys His Ile Ala Asn Glu Ile Lys Glu Glu Asp Ile Pro Ile 
                485                 490                 495     


Ile Leu Arg Leu Tyr Lys Gln Asp Cys Glu Asn Val Asn Lys Ala Phe 
            500                 505                 510         


Ala Asn Arg Ile Ser Ser Met Asn Leu Pro Leu Tyr Tyr Ser Thr Glu 
        515                 520                 525             


Phe Leu Leu Arg Ile Phe Lys Lys Gln Gly Ala Glu Leu Ser Leu Tyr 
    530                 535                 540                 


Ser Thr Lys Asn Gln Met Thr Pro Ser Phe Lys Arg Val Tyr Glu Arg 
545                 550                 555                 560 


Gly Lys Asn Leu Arg Leu Glu Tyr Glu Arg Glu Pro Met Arg Ser Asn 
                565                 570                 575     


Ile Ala Asn Glu Tyr Asp Lys Asp Pro Gln Ser Asp Tyr Trp Met Arg 
            580                 585                 590         


Trp Phe Ser Gln Phe Ala Thr Gly Thr Val Asp Thr Asn Ala Gly Ile 
        595                 600                 605             


Lys Gly Glu Met Glu Asp Tyr Pro His Ala Ser Val Asn Leu Gly Ile 
    610                 615                 620                 


Glu Ile Glu Ala Gly Thr Asn Ile Asp Ala Gln Arg Ala Met Arg Asn 
625                 630                 635                 640 


Leu Leu Gln Leu Ile Tyr Lys His His Phe Leu Pro Glu Val Gln Lys 
                645                 650                 655     


Asp Glu Thr Val Val Thr Asp Val Ile Pro Lys Val Leu Glu Arg Asn 
            660                 665                 670         


Arg Lys Leu Ser Glu Val Arg Asn Arg Ser Asp Lys Thr Tyr Gly Tyr 
        675                 680                 685             


Lys Glu Ile Glu Glu Leu Cys Lys Lys Asn Lys Gly Lys Lys Asp Ser 
    690                 695                 700                 


Leu Ser Glu Leu Met Lys Asp Leu Gln Arg Lys Val Ser Glu Thr Glu 
705                 710                 715                 720 


Lys Glu Lys Arg Glu Leu Ala Arg Glu Lys Thr Asp Tyr Ala Gln Arg 
                725                 730                 735     


Phe Ile Leu Asp Ile Phe Ala Glu Ala Phe Cys Asn Phe Met Asp Glu 
            740                 745                 750         


Arg Tyr Glu Asp Glu Tyr Gln Glu Ile Met Ser Pro Ile Lys Asn Glu 
        755                 760                 765             


Glu Glu Ala Lys Lys Trp Thr Glu Met Phe Thr Asp Lys Ala Asp Lys 
    770                 775                 780                 


Asp Asn Lys Asp Lys Leu Leu Val Leu Lys Thr Ser Phe Asp Lys Asp 
785                 790                 795                 800 


Asn Val Glu Lys Tyr Leu Leu Val Leu Tyr Pro Leu Met Arg Leu Leu 
                805                 810                 815     


Asp Asp Lys Glu Leu Ser Glu Leu Gln Gln Gln Met Leu Arg Phe Arg 
            820                 825                 830         


Ala Ser Val Ser Gly Trp Gln Gly Gly Thr Asp Phe Ser Glu Asp Ile 
        835                 840                 845             


Ala Met Ala Glu Lys Ile Glu Glu Leu Ala Glu Leu Val Lys Leu Thr 
    850                 855                 860                 


Glu Pro Glu Ser Gln Tyr Ala Glu Glu Ala Trp Lys Asn Arg Ala Ile 
865                 870                 875                 880 


Gly Val Phe Glu Gln Phe Val Glu Gly Lys Met Ala Glu Tyr Gly Thr 
                885                 890                 895     


Phe Tyr Ile Gln Asn Asp Ser Leu Thr Gln Val Pro Arg Gly Asn Met 
            900                 905                 910         


Arg Lys Leu Leu Arg Ser Gly Val Ile Gly Val Tyr Asn Lys Val Leu 
        915                 920                 925             


Ala Ser Cys Lys Gln Ala Thr Lys Ala Asp Tyr Gly Ala Tyr Ser Gly 
    930                 935                 940                 


Asp His Trp Ser Ile Glu Asp Pro Asp Gly Asn Pro Ile Lys Ser Ala 
945                 950                 955                 960 


Glu Gln Ala Gln Ala Leu Leu Gln Arg Leu His Lys Lys Tyr Thr Glu 
                965                 970                 975     


Ser Pro Ser Gln Phe Ser Asp Asp Asp His Lys Leu Tyr Asp Lys Thr 
            980                 985                 990         


Leu Arg Gln Leu Asp Ala Tyr Asn  Arg Ala Met Lys Asn  Leu Ser Phe 
        995                 1000                 1005             


Gly Ser  Leu Tyr Glu Ile Cys  Arg Ile His Met Glu  Thr Leu Ser 
    1010                 1015                 1020             


Arg Trp  Val Gly Phe Val Gln  Asp Trp Glu Arg Asp  Met Tyr Phe 
    1025                 1030                 1035             


Leu Leu  Leu Ala Trp Thr Lys  Gln Gly Lys Leu Leu  Asn Val Thr 
    1040                 1045                 1050             


Glu Thr  Asp Val Ile Glu Ile  Phe Glu Lys Gly Ser  Val Ile Tyr 
    1055                 1060                 1065             


Lys Met  Asn Lys Lys Leu Lys  Asn Gly Asp Arg Tyr  Ala Phe Thr 
    1070                 1075                 1080             


Ser Ile  Tyr Arg Asn Asn Asn  Asp Glu Lys Leu Glu  Phe Leu Gln 
    1085                 1090                 1095             


Ile Arg  Asn Phe Ile Ala His  Leu His Leu Leu Arg  Lys Ser Glu 
    1100                 1105                 1110             


Trp Lys  Gly Asp Lys Lys Ala  Gly Tyr Ser Val Ile  Glu Asp Tyr 
    1115                 1120                 1125             


Ile Asn  Lys Leu Arg Phe Leu  Leu Ser Tyr Asp Gln  Lys Arg Met 
    1130                 1135                 1140             


Asn Ala  Val Thr Lys Ala Met  Gln Gln Ile Phe Glu  Lys His Lys 
    1145                 1150                 1155             


Val Ile  Val Lys Phe Met Val  Glu Lys Gly Gly 
    1160                 1165                 


<210>  1301
<211>  1161
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1301

Met Lys Val Thr Lys Val Asp Gly Ile Ser His Lys Lys Tyr Ile Glu 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Arg Thr Ser Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Ser Ile Arg Leu Asp Ile Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu Tyr Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Asn Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Glu Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Lys Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Tyr Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Val 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Asn Phe Tyr Glu Lys Asp Val Ile Ile Lys Tyr Leu Lys Asn Thr Lys 
    530                 535                 540                 


Phe Asn Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Asn Lys Ile Asp Asp Leu Arg Asn Thr Leu Lys Phe Ser Trp 
                565                 570                 575     


Lys Ile Pro Lys Asp Lys Glu Glu Lys Asp Ala Gln Ile Tyr Leu Leu 
            580                 585                 590         


Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn Lys Phe Val Lys Asn Ser 
        595                 600                 605             


Lys Asp Phe Phe Lys Ile Thr Asp Glu Val Ile Lys Ile Asn Lys Gln 
    610                 615                 620                 


Arg Asn Gln Lys Thr Gly Tyr Tyr Lys Tyr Gln Lys Phe Glu Asn Ile 
625                 630                 635                 640 


Glu Lys Thr Val Pro Val Glu Tyr Leu Ala Ile Ile Gln Ser Arg Glu 
                645                 650                 655     


Met Ile Asn Asn Gln Asp Lys Glu Glu Lys Asn Thr Tyr Ile Asp Phe 
            660                 665                 670         


Ile Gln Gln Ile Phe Leu Lys Gly Phe Ile Asp Tyr Leu Asn Lys Asn 
        675                 680                 685             


Asn Leu Lys Tyr Ile Glu Asn Asn Asn Asn Asn Asp Ile Phe Ser Arg 
    690                 695                 700                 


Ile Gln Ile Lys Lys Asp Ser Lys Glu Arg Tyr Asp Lys Ile Leu Lys 
705                 710                 715                 720 


Asn Tyr Glu Lys Asn Asn Arg Asn Lys Glu Ile Pro His Glu Ile Asn 
                725                 730                 735     


Glu Phe Val Arg Glu Ile Lys Leu Gly Lys Ile Leu Lys Tyr Thr Glu 
            740                 745                 750         


Ser Leu Asn Met Phe Tyr Leu Ile Leu Lys Leu Leu Asn His Lys Glu 
        755                 760                 765             


Leu Thr Asn Leu Lys Gly Ser Ile Glu Lys Tyr Gln Ser Ala Asn Lys 
    770                 775                 780                 


Glu Glu Thr Phe Ser Asp Glu Leu Glu Leu Ile Asn Leu Leu Asn Leu 
785                 790                 795                 800 


Asp Asn Asn Arg Val Thr Glu Asp Phe Glu Leu Glu Ala Asp Glu Ile 
                805                 810                 815     


Gly Lys Phe Leu Asn Phe Asn Gly Asn Lys Val Lys Asp Arg Lys Glu 
            820                 825                 830         


Leu Lys Lys Phe Asp Thr Lys Lys Ile Tyr Phe Asp Gly Glu Asn Ile 
        835                 840                 845             


Ile Lys His Arg Ala Phe Tyr Asn Ile Lys Lys Tyr Gly Met Leu Asn 
    850                 855                 860                 


Leu Leu Glu Lys Ile Ser Asp Glu Ala Lys Tyr Lys Ile Ser Ile Glu 
865                 870                 875                 880 


Glu Leu Lys Asn Tyr Ser Asn Lys Lys Lys Glu Ile Glu Lys Asn His 
                885                 890                 895     


Thr Thr Gln Glu Asn Leu His Arg Lys Tyr Ala Arg Pro Arg Lys Asp 
            900                 905                 910         


Glu Lys Phe Thr Asp Glu Asp Tyr Glu Ser Tyr Lys Gln Ala Ile Lys 
        915                 920                 925             


Asn Ile Glu Glu Tyr Thr His Leu Lys Asn Lys Val Glu Phe Asn Glu 
    930                 935                 940                 


Leu Asn Leu Leu Gln Gly Leu Leu Leu Arg Ile Leu His Arg Leu Val 
945                 950                 955                 960 


Gly Tyr Thr Ser Ile Trp Glu Arg Asp Leu Arg Phe Arg Leu Lys Gly 
                965                 970                 975     


Glu Phe Pro Glu Asn Gln Tyr Ile Glu Glu Ile Phe Asn Phe Glu Asn 
            980                 985                 990         


Lys Lys Asn Val Lys Tyr Lys Ser  Gly Gln Ile Val Glu  Lys Tyr Ile 
        995                 1000                 1005             


Lys Phe  Tyr Lys Glu Leu His  Gln Asn Asp Glu Val  Lys Ile Asn 
    1010                 1015                 1020             


Lys Tyr  Ser Ser Ala Asn Ile  Lys Val Leu Lys Gln  Glu Lys Lys 
    1025                 1030                 1035             


Asp Leu  Tyr Ile Arg Asn Tyr  Ile Ala His Phe Asn  Tyr Ile Pro 
    1040                 1045                 1050             


His Ala  Glu Ile Ser Leu Leu  Glu Val Leu Glu Asn  Leu Arg Lys 
    1055                 1060                 1065             


Leu Leu  Ser Tyr Asp Arg Lys  Leu Lys Asn Ala Val  Met Lys Ser 
    1070                 1075                 1080             


Val Val  Asp Ile Leu Lys Glu  Tyr Gly Phe Val Ala  Lys Phe Lys 
    1085                 1090                 1095             


Ile Gly  Ala Asp Lys Lys Ile  Glu Ile Gln Ser Leu  Lys Ser Glu 
    1100                 1105                 1110             


Glu Ile  Val His Leu Lys Lys  Leu Lys Leu Lys Asp  Asn Asp Lys 
    1115                 1120                 1125             


Lys Lys  Glu Pro Ile Lys Thr  Tyr Arg Asn Ser Lys  Glu Leu Cys 
    1130                 1135                 1140             


Lys Leu  Val Lys Val Met Phe  Glu Tyr Lys Met Glu  Glu Lys Lys 
    1145                 1150                 1155             


Ser Glu  Asn 
    1160     


<210>  1302
<211>  979
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1302

Met Asp Val Lys Val Gln Pro Asp Leu Asn Asp Asn Ser Ile Leu Lys 
1               5                   10                  15      


Leu Ser Gly Leu Gly Asn Ile Lys Lys Glu Ala Leu Ser Asp Thr Leu 
            20                  25                  30          


Leu Arg Tyr Ala Ala Ser Ala Asp Glu Ser Asp Gln Val Leu Leu Asp 
        35                  40                  45              


Ile Lys Lys Leu Leu Phe Glu Tyr Phe Leu Pro Glu Asn Ser Lys Glu 
    50                  55                  60                  


Thr Ser Lys Tyr Thr Thr Val Gln Asn Leu Trp Asn Ile Pro Tyr Leu 
65                  70                  75                  80  


Pro Lys Ile Phe Phe Asp Tyr Gly Phe Glu Asn Glu Asp Ser Asp Asp 
                85                  90                  95      


Asp Asn Glu Cys Ala Glu Asp Ile Glu Thr Leu Cys Asp Val Glu Pro 
            100                 105                 110         


Gln Tyr Lys Ile Asn Gln His Ser Leu Lys Arg Arg Ile Arg Tyr Val 
        115                 120                 125             


Asn Tyr Gly Lys Tyr Leu Gln Met Thr Lys Asn Glu Ser Asp Arg Glu 
    130                 135                 140                 


Arg Arg Tyr Trp Ile His Tyr Ile Lys Glu Phe Val Glu Lys Asn Tyr 
145                 150                 155                 160 


Val Asp Ser Gly Arg Thr Leu Ser Glu Lys Asn Cys Tyr Ala Ser Ser 
                165                 170                 175     


Met Met Leu Asn Cys Trp Lys Glu Ile Ile Arg Tyr Leu Cys Gly Lys 
            180                 185                 190         


Tyr Ile Asp Ile Gly Lys Ala Val Phe His Phe Thr Asn Leu Thr Ala 
        195                 200                 205             


Met Pro Lys Pro Lys Asp Lys Ile Ile Tyr Gly Gln Leu Glu Glu Gln 
    210                 215                 220                 


Tyr Lys Lys Gly Ile Ser Ser Phe Asp Tyr Glu Ala Ile Lys Ala Glu 
225                 230                 235                 240 


Glu Thr Leu Gln Arg Asp Ile Val Gln Ser Val Val Ala Ala Ala Phe 
                245                 250                 255     


Ala Phe Ser Lys Ser Val Ile Asp Glu Thr Lys Met Glu Glu Cys Gln 
            260                 265                 270         


Glu Thr Asn Lys Glu Asp Ile Leu Phe Leu Ser Glu Asn Val Leu Gly 
        275                 280                 285             


Ser Leu Leu Lys Glu Asn Thr Ile Lys Leu Ile Leu Arg Phe Tyr Gly 
    290                 295                 300                 


Gly Glu Ser Ser Val Ala Gln Lys Glu Tyr Phe Asp Gln Gln Glu Ile 
305                 310                 315                 320 


Val Gln Glu Met Ile Ser His Leu Lys Ser Ile Arg Asn Glu Asn Phe 
                325                 330                 335     


His Tyr Leu Asp Gly Ala Lys Lys Asp Asn Pro His Lys Tyr Ala Ser 
            340                 345                 350         


Ile Leu Trp Lys Asn Asp Glu Met Ala Tyr Gln Lys Leu Thr Lys Gln 
        355                 360                 365             


Arg Tyr Tyr Ala Asn Asn Val Gly Leu Phe Tyr Arg Ala Glu Glu Ile 
    370                 375                 380                 


Gln Glu Leu Val Gln Glu Leu Tyr Ser Gln Lys Asn Ile Thr Glu Ala 
385                 390                 395                 400 


Gln Ile Pro Ala Phe Arg Thr Val Leu Lys Arg Lys Asp Leu Pro Gly 
                405                 410                 415     


Tyr Met Glu Glu Leu Gly Ile Leu Phe Pro Asp Asn Thr Gln Glu Lys 
            420                 425                 430         


Ser Lys Gly Asp Phe Glu Gly Thr Leu Tyr Phe Leu Met Lys Glu Ile 
        435                 440                 445             


Tyr Tyr Arg Asp Phe Ile Val Lys Asp Lys Ala Ala Ala Tyr Phe Phe 
    450                 455                 460                 


Lys Ala Val Asp Gln Asn Lys Glu Gln Ser Lys Lys Glu Asp Lys His 
465                 470                 475                 480 


Thr Glu Arg Ala Ala Glu Asn Phe His Arg Tyr Val Lys Ser Leu Glu 
                485                 490                 495     


Lys Lys Tyr Asn Lys Lys Glu Ile Ser Phe Gly Thr Val Cys Gln Tyr 
            500                 505                 510         


Ile Met Met Glu Tyr Asn Gln Gln Asn Thr Thr Lys Gln Glu Thr Glu 
        515                 520                 525             


Ile Tyr Lys His Phe Lys Met Leu Ile Ser Leu Cys Ile Arg Lys Ala 
    530                 535                 540                 


Phe Gly Asn Tyr Ile Lys Glu Thr Tyr Arg Phe Leu Phe His Pro Ile 
545                 550                 555                 560 


Tyr Ser Lys Gln Gln Gly Glu Pro Glu Tyr Leu Asp Thr Leu Glu Leu 
                565                 570                 575     


Glu Ser Gly Val Lys Glu Lys Asn Tyr Glu Trp Phe Thr Leu Ala His 
            580                 585                 590         


Phe Leu His Pro Val Gln Leu Asn His Leu Val Gly Asp Leu Lys Ser 
        595                 600                 605             


Tyr Ile Gln Tyr Arg Glu Asp Ile Leu Arg Arg Ile Val Phe Ala Glu 
    610                 615                 620                 


Gln Arg Val Tyr Ala Asp Gln Gln Lys Glu Val Gln Gln Lys Val Lys 
625                 630                 635                 640 


Thr Ala Lys Glu Ile Leu Glu Val Leu Glu Phe Val Arg Glu Val Ser 
                645                 650                 655     


Gly Arg Val Ser Asn Glu Tyr Thr Asp Tyr Tyr Glu Asn Glu Glu Glu 
            660                 665                 670         


Tyr Ala Glu Phe Leu Tyr Gln Tyr Ile Asp Phe Arg Lys Arg Glu Gly 
        675                 680                 685             


Lys Ser Ala Phe Glu Ser Leu Lys Tyr Phe Cys Gln Asn Ile Leu Asp 
    690                 695                 700                 


Ser Gly Thr Val Val Asp Leu Tyr Ala Asp Thr Glu Asn Pro Lys Val 
705                 710                 715                 720 


Leu Arg Asn Ile Glu Leu Thr Arg Met Tyr Ala Gly Ser Asn Val Lys 
                725                 730                 735     


Ile Pro Glu Tyr Glu Lys Ile Thr Glu Asp Glu Ile Lys Met Tyr Tyr 
            740                 745                 750         


Gln Glu Lys Asn Ser Val Ala Leu Ile Leu Ser Arg Gly Leu Cys Arg 
        755                 760                 765             


Asn Glu Lys Glu Gln Lys Lys Val Ile Glu Phe Asn Trp Lys Lys Lys 
    770                 775                 780                 


Arg Leu Thr Leu Asn Glu Ile Thr Asp Val Phe Ser Leu Val Asn Asp 
785                 790                 795                 800 


Leu Leu Gly Lys Met Ile Ser Phe Ser Tyr Leu Arg Glu Arg Asp Gln 
                805                 810                 815     


Met Tyr Leu Leu Leu Gly Phe Tyr Tyr Met Ala Leu Cys Ala Glu Asn 
            820                 825                 830         


Lys Ser Glu Asn His Leu Gly Trp Lys Gly Glu Thr Leu Asp Lys Leu 
        835                 840                 845             


Glu Ser Ser Asp Ser Lys Phe Asp Ile Gly Gly Gly Leu Val Leu Tyr 
    850                 855                 860                 


Gln Ile Val Ser Ala Phe Asn Phe Gly Ser Lys Leu Leu Tyr Ile Ser 
865                 870                 875                 880 


Glu Asp Gly Arg Trp Lys Met Ala Gly Gly Ala Phe Pro Gly Lys Tyr 
                885                 890                 895     


Gly Arg Phe Glu Asn Asp Tyr Asn His Arg Thr Ser Leu Ser Lys Val 
            900                 905                 910         


Ile Arg Leu Phe Glu Asn Glu Ser Tyr Glu Arg Glu Ile Ile Tyr Trp 
        915                 920                 925             


Arg Asp Tyr Val Asp His Met Lys Tyr Tyr Val Asn Gln Asn Gln Ser 
    930                 935                 940                 


Ile Met Glu Ile Tyr Ser Ala Phe Tyr Ser Lys Val Leu Gly Tyr Ser 
945                 950                 955                 960 


Ala Lys Leu Arg Lys Ser Val Tyr Leu Ile Cys Arg Leu His Leu Lys 
                965                 970                 975     


Ser Ile Ile 
            


<210>  1303
<211>  907
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1303

Val Lys Phe Ser Lys Val Asn Asn Leu Lys Thr Ala Val Thr Leu Asp 
1               5                   10                  15      


Lys Asn Asn Asp Gly Lys Thr Gly Ile Leu Tyr Arg Asp Pro Ala Arg 
            20                  25                  30          


Lys Glu Arg Ser Val Gln Arg Asp Ile Gly Thr His Val Ser Arg Gln 
        35                  40                  45              


Ile Asp Lys Ser Lys Asn Leu Tyr Arg Leu Phe Asn Ala Ser Gln Glu 
    50                  55                  60                  


Asp Glu Glu Glu Val Pro Glu Leu Phe Phe Ala Asn Arg Leu Asn Glu 
65                  70                  75                  80  


Thr Ile Lys Lys Gln Met Ile Glu Lys Met Val Lys Ser Asp Phe Thr 
                85                  90                  95      


Ala Asp Arg Leu Cys Ser Leu Leu Lys Lys Val Ser Asp Glu Met Gly 
            100                 105                 110         


Tyr Ala Phe Ser Gln Gln Ile Ile Asp Ser Ala Ile Asn Arg Phe Leu 
        115                 120                 125             


Arg Arg Asn Leu Tyr Ile Asn Ala Ala Lys Gly Leu Lys Thr Ala Leu 
    130                 135                 140                 


Met Val Gly Phe Gly Leu Met Pro Gln Asp Gln Leu Thr Ala Glu Asp 
145                 150                 155                 160 


Lys Lys Glu Ile Glu His Phe Leu Ser Val Leu Arg Asp Asp Tyr Glu 
                165                 170                 175     


His Gln Ala Ile Ile Lys His Val Glu Lys Ser Ile Thr His Gln Asn 
            180                 185                 190         


Met Leu Ile Gln Pro Asn Lys Glu Gly Leu Phe Val Pro Ala Glu Ile 
        195                 200                 205             


Pro Gln Ala Gln Asn Arg Ser Lys Asn Glu Lys Glu Ala Phe Glu Arg 
    210                 215                 220                 


Phe Leu Leu Ser Tyr Ala Val Leu Asp Glu Lys Ile Arg His Asp Leu 
225                 230                 235                 240 


Arg Leu Arg Leu Arg Arg Leu Val Asp Leu Tyr Phe Tyr Gly Glu Ser 
                245                 250                 255     


Ala Val Lys Gln Glu Asp Phe Asp Glu Trp Lys Asp His Ala Gly His 
            260                 265                 270         


Lys Gly Asp Thr Met Pro Phe Ser Glu Lys Ala Ser Asp Leu Ile Pro 
        275                 280                 285             


Ile Ile Leu Arg Ala Gln Asp Lys Asn Leu Asp Asp Glu Ala Lys Lys 
    290                 295                 300                 


Glu Ala Lys Glu Lys Ala Lys Glu Ala Lys Thr Asp Ile Phe Arg Tyr 
305                 310                 315                 320 


Leu Arg Glu Glu Asn Thr Ser Arg Tyr Arg Arg Cys Ile Ser Ala Val 
                325                 330                 335     


Lys Asn Ala Val Asn Thr Asp Leu Tyr Phe Glu Asp Met Met Ile Asn 
            340                 345                 350         


Gln Phe Trp Ile His His Ile Glu Asp Ala Val Glu Arg Ile Cys Asp 
        355                 360                 365             


Asn Ile Arg Lys Pro Glu Ser Phe Arg Leu Cys Val Gly Tyr Leu Gly 
    370                 375                 380                 


Glu Lys Val Trp Lys Asp Cys Leu Asn Tyr Leu Ser Ile Lys Tyr Ile 
385                 390                 395                 400 


Ala Ile Gly Lys Thr Val Tyr His Tyr Ala Met Ser Ser Asp Ile Ala 
                405                 410                 415     


Asp Ser Thr Lys Ser Val Thr Leu Gly Lys Ile Ala Pro Asp Lys Met 
            420                 425                 430         


Lys Gly Leu Thr Ser Phe Asp Tyr Glu Gln Ile Lys Ala Glu Glu Thr 
        435                 440                 445             


Leu Gln Arg Ser Leu Ala Val Tyr Val Thr Phe Ala Ala Asn His Leu 
    450                 455                 460                 


Ala Gly Glu Thr Val Lys Arg Glu Asn Lys Ser Gln Lys Glu Asp Phe 
465                 470                 475                 480 


Phe Thr Leu Lys Lys Gly Asp Leu Lys Asp Gln Gln Lys Pro His Leu 
                485                 490                 495     


Arg Arg Asn Ile Phe Gln Phe Phe Gly Gly Gln Ser Arg Trp Gln Asp 
            500                 505                 510         


Phe Pro Phe Glu Lys Tyr Phe Ile Ser Glu Tyr Thr Asp Leu Asp Phe 
        515                 520                 525             


Leu Tyr Asp Leu Gln Gln Ile Leu Tyr Ser Leu Arg Asn Glu Ser Phe 
    530                 535                 540                 


His Phe Asp Thr Arg Asn His Asn Met Gly Asp Trp Asn Gln Pro Leu 
545                 550                 555                 560 


Ile Ile Ala Met Phe Glu Tyr Asp Cys Lys Gln Cys Ser Val Leu Gln 
                565                 570                 575     


Lys Ser Lys Phe Tyr Ser Asn Asn Leu Pro Met Phe Tyr Gly Gln Lys 
            580                 585                 590         


Asp Leu Glu Lys Ile Leu Lys Arg Leu Tyr Glu Val Gln Ala Gly Arg 
        595                 600                 605             


Ala Ser Gln Val Pro Ser Phe Asn Ser Val Phe Val Arg Asn Asn Phe 
    610                 615                 620                 


Lys Glu Phe Ile Arg Asn Asn Leu Gly Trp Asn Ile Asn Phe Thr Glu 
625                 630                 635                 640 


Glu Lys Ser Thr Glu Asn Leu Asp Lys Phe Glu Ser Gly Leu Tyr Tyr 
                645                 650                 655     


Leu Leu Lys Glu Ile Tyr Tyr Asn Leu Phe Leu Gln Gly Lys Gly Leu 
            660                 665                 670         


Thr Gly Asp Tyr Asp Val Lys Lys Gln Phe Ile Asn Trp Ser Arg Lys 
        675                 680                 685             


Lys Thr Asp Glu Glu His Lys Phe Ala Ala Ile Asn Phe Ser Gln Arg 
    690                 695                 700                 


Ile Lys Ser Leu Glu Glu Gly Glu Arg Glu Phe Ser Phe Ser Glu Ile 
705                 710                 715                 720 


Cys Gln Ser Ile Met Thr Glu Tyr Asn Leu Tyr Asn Asn Asn Arg Lys 
                725                 730                 735     


Val Lys Ser Asp Tyr Val Lys Lys Asn His Pro Asp Ser Tyr Ala His 
            740                 745                 750         


Tyr Lys Leu Leu Leu Tyr Lys Gly Ile Arg Glu Val Phe Ala His Tyr 
        755                 760                 765             


Ile Lys Thr Gln Phe Ser Leu Leu Ala Glu Pro Ser Leu Arg Glu Lys 
    770                 775                 780                 


Pro Ala Glu Glu Asp Phe Leu Pro Ser Tyr Thr Thr Gly Ala Tyr Lys 
785                 790                 795                 800 


Glu Leu Ile Asp Arg Val Arg Lys Asn Ile Asp Leu Gln Lys Trp Tyr 
                805                 810                 815     


Ile Leu Gly Arg Phe Leu Asn Ala Arg Gln Ala Asn Leu Leu Ile Gly 
            820                 825                 830         


Gln Val Arg His Tyr Ala Gln Tyr Ser Ser Asp Val Arg Arg Arg Ala 
        835                 840                 845             


Ala Glu Thr Arg Asn Gln Thr Leu Gln Glu Val Ser Lys Lys Glu Leu 
    850                 855                 860                 


Asp Gly Tyr Glu Lys Val Leu Asp Val Cys Ile Lys Leu Ser Gly Met 
865                 870                 875                 880 


Thr Ser Asn Asn Leu Glu Asp Tyr Phe Asp Asp Lys Asp Asp Tyr Ala 
                885                 890                 895     


Lys His Ile Ser His Tyr Leu Ala Phe Thr Glu 
            900                 905         


<210>  1304
<211>  1170
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1304

Met Lys Ile Thr Lys Asn Thr Lys Asn Gly Lys Leu Glu Phe Tyr Arg 
1               5                   10                  15      


Asp Val Lys Glu Gly Gly Leu Arg Asp Pro Lys Ser Lys Thr Ile Trp 
            20                  25                  30          


Thr Ser Glu Thr Ile Lys Arg Leu Asp Ile Asn Lys Ser Leu Lys Gly 
        35                  40                  45              


Arg Ile Leu Ala Tyr Gly Thr Ser Leu Gly Ser Ser Asn Pro Tyr Ser 
    50                  55                  60                  


Val Phe Val Asp Ser Leu Ile Arg Glu Asn Lys Glu Ile Ser Leu Ser 
65                  70                  75                  80  


Glu Leu Lys Arg Glu Gln Cys Lys Lys Glu Asn Val Gln Lys Tyr Leu 
                85                  90                  95      


Ser Ala Tyr Gly Arg Met Ile Asn Tyr Cys Thr Glu Glu Asn Thr Ser 
            100                 105                 110         


Leu Gly Asn Leu Leu Val Glu Tyr Gly Asn Gly Ala Glu Ile Ser Glu 
        115                 120                 125             


Ala Leu Val Gln Ile Lys Lys Gln Ile Leu Lys Leu Lys Arg His Lys 
    130                 135                 140                 


Lys Lys Ser Leu Leu Asp Ser Phe Met Asn Asn Lys Ile Pro Phe Lys 
145                 150                 155                 160 


Leu Thr Asn Gly Lys Leu Glu Pro Ala Thr Asp Lys Met Ser Arg Leu 
                165                 170                 175     


Phe Ser Leu Leu Glu Glu Asp Gly Val Asp Lys Asn Lys Phe Glu Lys 
            180                 185                 190         


Tyr Lys Thr Trp Tyr Gln Tyr Glu Val Leu Lys Lys Arg Leu Asp Leu 
        195                 200                 205             


Ile Cys Glu Glu His Phe Ser Ala Ala Glu Arg Lys Pro Arg Val Leu 
    210                 215                 220                 


Ala Lys Lys Ile Tyr Ser Ala Val Lys Leu Tyr Asn Lys Glu Lys Ala 
225                 230                 235                 240 


Asn Ser Asp Val Ile Lys Asn Lys Asp Asp Ala His Ser Leu Phe Leu 
                245                 250                 255     


Asp Glu Ile Arg Asp His Phe Arg Lys Tyr Phe Pro Val Thr Gly Lys 
            260                 265                 270         


Lys Gly Leu Ser Ser Gly Gly Asp Ser Glu Lys Leu Asn Ser Leu Ala 
        275                 280                 285             


Ser Glu Lys Asn Val Lys Tyr Tyr Tyr Ser Asp Lys Tyr Val Phe Gln 
    290                 295                 300                 


Gln Val Trp Arg Gln Ile Val Asn Gln Leu Thr Ala Gly Leu Ile Gln 
305                 310                 315                 320 


Tyr Gly Lys Leu Ser Tyr Tyr Phe His Asp Lys Glu Asn His Thr Trp 
                325                 330                 335     


Gln Glu Glu Lys Leu Asn Ser Glu Gly Met Gln Glu Ile Gln Val Arg 
            340                 345                 350         


Glu Thr Phe Lys Lys Gln Leu Phe Leu Ser Val Val Trp Ser Val Asn 
        355                 360                 365             


Lys Leu Asn Tyr Phe Phe Gln Tyr Gly Gly Glu Asn Pro Lys Met Leu 
    370                 375                 380                 


Tyr Gln Val Lys Tyr Asp Glu Asp Cys Ile Ala Gly Asp Ile Ile Glu 
385                 390                 395                 400 


Glu Leu Arg Lys Ala Asp Phe Ser Arg Phe Cys Tyr Asp Asp Pro Ile 
                405                 410                 415     


Lys Asn Asn Tyr Ile His Arg Phe Met His Gly Ile Lys Glu Glu Pro 
            420                 425                 430         


Glu Lys Phe Glu Leu Leu Phe Asp Lys Met Ser Val Ser Tyr Pro Leu 
        435                 440                 445             


Glu Glu Glu Asp Lys Asn Pro Glu Glu Ile Leu Lys Val Leu Gln Glu 
    450                 455                 460                 


Ile Asn Cys Ser Val Thr Asp Leu Arg His Ser Ile Ile His Tyr Gln 
465                 470                 475                 480 


Lys Asp Val Val Tyr Gln Glu Thr Gln Gly Pro Lys Tyr Pro Lys Ala 
                485                 490                 495     


Ser Glu Phe Leu Arg Arg Asp Ile Asp Asn Ile Glu Asn Cys Phe Leu 
            500                 505                 510         


Glu Gln Ile Arg Ser Met Ser Leu Ala Glu Tyr Tyr Pro Leu Asp Leu 
        515                 520                 525             


Leu Gln Lys Val Phe Lys Asp Cys Asn Leu Asn Phe Gln Leu Tyr Ala 
    530                 535                 540                 


Ser Gln Val Pro Met Val Pro Ser Phe Gln Lys Val Phe Gly Lys Gly 
545                 550                 555                 560 


Val Asn Leu Tyr Lys Ala Asp Gln Lys Ser Gly Ser Leu Lys Trp Tyr 
                565                 570                 575     


Met Glu Glu Arg Lys Asp Pro Glu Ala Lys Leu Ala Thr Leu Ala Tyr 
            580                 585                 590         


Arg Asn Phe Ile Gln Leu Ile Tyr Tyr His Gly Phe Leu Pro Ala Val 
        595                 600                 605             


Glu Lys Asn Asn Ala Leu Val Thr Asp Phe Ile Asn Glu Thr Val Glu 
    610                 615                 620                 


Trp Asn Gln Glu Arg Ser Leu Gln Ser Gln Arg Glu Asp Pro Glu Thr 
625                 630                 635                 640 


Lys Tyr Ile Asn Phe Ser Lys Tyr Arg Tyr Gln Gly Met Pro Glu Phe 
                645                 650                 655     


Gln Asn Lys Ser Leu Leu Glu Tyr Met Ser Glu Leu Gln Arg Asp Gln 
            660                 665                 670         


Ser Asn Lys Glu Lys Glu Asp Ser Lys Ala Gly Val Pro Glu Asp Lys 
        675                 680                 685             


Lys Lys Arg Tyr Tyr Thr Lys Phe Ile Gln Asp Ile Phe Ala Phe Ser 
    690                 695                 700                 


Phe Gly Ser Phe Leu Asn Ser Lys Leu Asn Glu Cys Arg Glu Asp Leu 
705                 710                 715                 720 


Leu Gln Pro Arg Tyr Gln Glu Ile Lys Thr Asn Glu Asp Arg Glu Gln 
                725                 730                 735     


Arg Leu Lys Lys Leu Leu Glu Asp Leu Glu Met Lys Thr Asn Ile Lys 
            740                 745                 750         


Asn Gly Ser Pro Thr Gln Leu Ala Met Tyr Pro Phe Leu Lys Leu Leu 
        755                 760                 765             


Asp Gln Arg Gly Leu Asn Gln Leu Leu His Gln Phe Ile Arg Cys Ser 
    770                 775                 780                 


Ala Ser Val Lys Ser Gly Phe Met Gln Asp Asp Lys Ala Leu Asn Leu 
785                 790                 795                 800 


Asn Arg Glu Ile Glu Glu Leu Ile Ala Leu Val Ala Phe Thr Lys Arg 
                805                 810                 815     


Pro Leu Met Asn Thr Glu Ala Tyr Ser Arg Ala Ile Glu Met Leu Ser 
            820                 825                 830         


Glu Thr Phe Ile Glu Gly Glu Ile Lys Asp Tyr Ala Asp Leu Tyr Tyr 
        835                 840                 845             


Gln Ser Asp Gln Glu His Ser Val Leu His Arg Asn Ile Ala Tyr Met 
    850                 855                 860                 


Gly Gly Thr Gly Val Ile Ala Leu Tyr Ser Asp Val Leu Arg Asp Cys 
865                 870                 875                 880 


Tyr Arg Val Lys Lys Thr Asp Tyr Val Glu Tyr Lys Lys Ala Asn Ser 
                885                 890                 895     


Lys Glu Asn Gly Arg Gln Phe Thr Arg Ile Gly Glu Asp Gln Lys Arg 
            900                 905                 910         


Leu Gln Asp Leu His Glu Ser Leu Ile Gly Arg Tyr Asn Ser Gly Gln 
        915                 920                 925             


Ile Gln Glu Tyr Lys Lys Leu Leu Arg Lys Thr His Glu Tyr Asn Val 
    930                 935                 940                 


Leu Lys Lys Arg Ile Thr Phe Glu Asn Met Tyr Glu Ile Tyr Gln Leu 
945                 950                 955                 960 


His Thr Glu Leu Leu Gly Arg Leu Ala Ser Phe Ala Glu Asp Trp Glu 
                965                 970                 975     


Arg Asp Met Leu Phe Leu Leu Thr Gly Leu Glu Ser Arg Gly Leu Ile 
            980                 985                 990         


Glu Asp Arg Val Glu Lys Ile Phe  Leu Lys Asp Lys Gly  Gly Val Val 
        995                 1000                 1005             


Ala Lys  Met Asn Lys Asn Leu  Lys Asp Asn Glu Lys  Leu Leu Lys 
    1010                 1015                 1020             


Ser Leu  Tyr Cys Arg Glu Asp  Gln Glu Ser Thr Asp  Phe Trp Lys 
    1025                 1030                 1035             


Thr Phe  His Val Arg Asn Ala  Val Ala His Phe Asn  His Phe Thr 
    1040                 1045                 1050             


Gln Lys  Ser Gln Ser Lys Gly  Gly Ser Val Val Tyr  Gln Arg Ser 
    1055                 1060                 1065             


Ile Glu  Glu Leu Ile Asn Arg  Ile Arg Gly Leu Leu  Ala Tyr Asp 
    1070                 1075                 1080             


Met Lys  Arg Gln Asn Ala Val  Thr Gln Ala Val Gln  Lys Ile Phe 
    1085                 1090                 1095             


Asp Lys  His Gln Met Ile Ile  Lys Phe Lys Pro Val  Thr Ile Asn 
    1100                 1105                 1110             


Ser Asp  Pro Glu Lys Trp Val  Gly Thr Trp Asn Ile  Glu Phe Gly 
    1115                 1120                 1125             


Ile Asp  Cys Ile Arg Ser Lys  Asn Ile Val His Phe  Lys Asn Leu 
    1130                 1135                 1140             


Ser Asp  Arg Ile Cys Leu Ile  Glu Ala His Asp Arg  Asn Thr Ile 
    1145                 1150                 1155             


Lys Ala  Ile Glu Lys Leu Met  Lys Phe Lys Tyr Asn  
    1160                 1165                 1170 


<210>  1305
<211>  917
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1305

Val Lys Phe Ser Lys Val Asn Asn Leu Lys Thr Ala Val Thr Leu Asp 
1               5                   10                  15      


Lys Asn Asn Asp Gly Lys Thr Gly Ile Leu Tyr Arg Asp Pro Ala Arg 
            20                  25                  30          


Lys Glu Arg Ser Val Gln Arg Asp Ile Gly Thr His Val Ser Arg Gln 
        35                  40                  45              


Ile Asp Lys Ser Lys Asn Leu Tyr Arg Leu Phe Asn Ala Ser Gln Glu 
    50                  55                  60                  


Asp Glu Glu Glu Val Pro Glu Leu Phe Phe Ala Asn Arg Leu Asn Glu 
65                  70                  75                  80  


Thr Ile Lys Lys Gln Met Ile Glu Lys Met Val Lys Ser Asp Phe Thr 
                85                  90                  95      


Ala Asp Arg Leu Cys Ser Leu Leu Lys Lys Val Ser Asp Glu Met Gly 
            100                 105                 110         


Tyr Ala Phe Ser Gln Gln Ile Ile Asp Ser Ala Ile Asn Arg Phe Leu 
        115                 120                 125             


Arg Arg Asn Leu Tyr Ile Asn Ala Ala Lys Gly Leu Lys Thr Ala Leu 
    130                 135                 140                 


Met Val Gly Phe Gly Leu Met Pro Gln Asp Gln Leu Thr Ala Glu Asp 
145                 150                 155                 160 


Lys Lys Glu Ile Glu His Phe Leu Ser Val Leu Arg Asp Asp Tyr Glu 
                165                 170                 175     


His Gln Ala Ile Ile Lys His Val Glu Lys Ser Ile Thr His Gln Asn 
            180                 185                 190         


Met Leu Ile Gln Pro Asn Lys Glu Gly Leu Phe Val Pro Ala Glu Ile 
        195                 200                 205             


Pro Gln Ala Gln Asn Arg Ser Lys Asn Glu Lys Glu Ala Phe Glu Arg 
    210                 215                 220                 


Phe Leu Leu Ser Tyr Ala Val Leu Asp Glu Lys Ile Arg His Asp Leu 
225                 230                 235                 240 


Arg Leu Arg Leu Arg Arg Leu Val Asp Leu Tyr Phe Tyr Gly Glu Ser 
                245                 250                 255     


Ala Val Lys Gln Glu Asp Phe Asp Glu Trp Lys Asp His Ala Gly His 
            260                 265                 270         


Lys Gly Asp Thr Met Pro Phe Ser Glu Lys Ala Ser Asp Leu Ile Pro 
        275                 280                 285             


Ile Ile Leu Arg Ala Gln Asp Lys Asn Leu Asp Asp Glu Ala Lys Lys 
    290                 295                 300                 


Glu Ala Lys Glu Lys Ala Lys Glu Ala Lys Thr Asp Ile Phe Arg Tyr 
305                 310                 315                 320 


Leu Arg Glu Glu Asn Thr Ser Arg Tyr Arg Arg Cys Ile Ser Ala Val 
                325                 330                 335     


Lys Asn Ala Val Asn Thr Asp Leu Tyr Phe Glu Asp Met Met Ile Asn 
            340                 345                 350         


Gln Phe Trp Ile His His Ile Glu Asp Ala Val Glu Arg Ile Cys Asp 
        355                 360                 365             


Asn Ile Arg Lys Pro Glu Ser Phe Arg Leu Cys Val Gly Tyr Leu Gly 
    370                 375                 380                 


Glu Lys Val Trp Lys Asp Cys Leu Asn Tyr Leu Ser Ile Lys Tyr Ile 
385                 390                 395                 400 


Ala Ile Gly Lys Thr Val Tyr His Tyr Ala Met Ser Ser Asp Ile Ala 
                405                 410                 415     


Asp Ser Thr Lys Ser Val Thr Leu Gly Lys Ile Ala Pro Asp Lys Met 
            420                 425                 430         


Lys Gly Leu Thr Ser Phe Asp Tyr Glu Gln Ile Lys Ala Glu Glu Thr 
        435                 440                 445             


Leu Gln Arg Ser Leu Ala Val Tyr Val Thr Phe Ala Ala Asn His Leu 
    450                 455                 460                 


Ala Gly Glu Thr Val Lys Arg Glu Asn Lys Ser Gln Lys Glu Asp Phe 
465                 470                 475                 480 


Phe Thr Leu Lys Lys Gly Asp Leu Lys Asp Gln Gln Lys Pro His Leu 
                485                 490                 495     


Arg Arg Asn Ile Phe Gln Phe Phe Gly Gly Gln Ser Arg Trp Gln Asp 
            500                 505                 510         


Phe Pro Phe Glu Lys Tyr Phe Ile Ser Glu Tyr Thr Asp Leu Asp Phe 
        515                 520                 525             


Leu Tyr Asp Leu Gln Gln Ile Leu Tyr Ser Leu Arg Asn Glu Ser Phe 
    530                 535                 540                 


His Phe Asp Thr Arg Asn His Asn Met Gly Asp Trp Asn Gln Pro Leu 
545                 550                 555                 560 


Ile Ile Ala Met Phe Glu Tyr Asp Cys Lys Gln Cys Ser Val Leu Gln 
                565                 570                 575     


Lys Ser Lys Phe Tyr Ser Asn Asn Leu Pro Met Phe Tyr Gly Gln Lys 
            580                 585                 590         


Asp Leu Glu Lys Ile Leu Lys Arg Leu Tyr Glu Val Gln Ala Gly Arg 
        595                 600                 605             


Ala Ser Gln Val Pro Ser Phe Asn Ser Val Phe Val Arg Asn Asn Phe 
    610                 615                 620                 


Lys Glu Phe Ile Arg Asn Asn Leu Gly Trp Asn Ile Asn Phe Thr Glu 
625                 630                 635                 640 


Glu Lys Ser Thr Glu Asn Leu Asp Lys Phe Glu Ser Gly Leu Tyr Tyr 
                645                 650                 655     


Leu Leu Lys Glu Ile Tyr Tyr Asn Leu Phe Leu Gln Gly Lys Gly Leu 
            660                 665                 670         


Thr Gly Asp Tyr Asp Val Lys Lys Gln Phe Ile Asn Trp Ser Arg Lys 
        675                 680                 685             


Lys Thr Asp Glu Glu His Lys Phe Ala Ala Ile Asn Phe Ser Gln Arg 
    690                 695                 700                 


Ile Lys Ser Leu Glu Glu Gly Glu Arg Glu Phe Ser Phe Ser Glu Ile 
705                 710                 715                 720 


Cys Gln Ser Ile Met Thr Glu Tyr Asn Leu Tyr Asn Asn Asn Arg Lys 
                725                 730                 735     


Val Lys Ser Asp Tyr Val Lys Lys Asn His Pro Asp Ser Tyr Ala His 
            740                 745                 750         


Tyr Lys Leu Leu Leu Tyr Lys Gly Ile Arg Glu Val Phe Ala His Tyr 
        755                 760                 765             


Ile Lys Thr Gln Phe Ser Leu Leu Ala Glu Pro Ser Leu Arg Glu Lys 
    770                 775                 780                 


Pro Ala Glu Glu Asp Phe Leu Pro Ser Tyr Thr Thr Gly Ala Tyr Lys 
785                 790                 795                 800 


Glu Leu Ile Asp Arg Val Arg Lys Asn Ile Asp Leu Gln Lys Trp Tyr 
                805                 810                 815     


Ile Leu Gly Arg Phe Leu Asn Ala Arg Gln Ala Asn Leu Leu Ile Gly 
            820                 825                 830         


Gln Val Arg His Tyr Ala Gln Tyr Ser Ser Asp Val Arg Arg Arg Ala 
        835                 840                 845             


Ala Glu Thr Arg Asn Gln Thr Leu Gln Glu Val Ser Lys Lys Glu Leu 
    850                 855                 860                 


Asp Gly Tyr Glu Lys Val Leu Asp Val Cys Ile Lys Leu Ser Gly Met 
865                 870                 875                 880 


Thr Ser Asn Asn Leu Glu Asp Tyr Phe Asp Asp Lys Asp Asp Tyr Ala 
                885                 890                 895     


Lys His Ile Ser His Tyr Leu Ala Phe Thr Glu Asp Ile Pro Gly Val 
            900                 905                 910         


Ser Leu Ser Ala Gln 
        915         


<210>  1306
<211>  948
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1306

Met Arg Gly Gly Tyr Met Lys Ile Thr Lys Ile Gly Gly Ile Ser His 
1               5                   10                  15      


Lys Lys Tyr Glu Glu Lys Gly Lys Leu Ile Lys Ser Asn Glu Ile Glu 
            20                  25                  30          


Lys Asp Val Ile Glu Glu Arg Phe Asn Asp Ile Glu Lys Lys Thr Lys 
        35                  40                  45              


Glu Leu Phe Leu Lys Thr Leu Asp Ser Tyr Val Lys Asn Tyr Glu Lys 
    50                  55                  60                  


Cys Glu Glu Gln Asn Lys Glu Arg Arg Glu Lys Ala Lys Asn Tyr Phe 
65                  70                  75                  80  


Ser Lys Val Lys Leu Ile Ile Asp Asn Glu Lys Ile Thr Ile Cys Asn 
                85                  90                  95      


Glu Asn Thr Glu Lys Met Glu Ile Glu Asp Phe Asn Glu Tyr Asp Val 
            100                 105                 110         


Arg Asn Arg Lys Tyr Phe Asn Val Leu Asn Lys Ile Leu Asn Gly Glu 
        115                 120                 125             


Asn Tyr Thr Glu Glu Asp Leu Glu Val Phe Glu Asn Asp Leu Gln Lys 
    130                 135                 140                 


Lys Leu Asn Gln Ile Gln Ser Ile Lys Asn Ser Leu Glu Glu Asn Lys 
145                 150                 155                 160 


Ala His Phe Lys Lys Glu Ser Ile Asn Asn Thr Thr Asp Ile Val Lys 
                165                 170                 175     


Gly Asn Asn Lys Lys Ser Leu Phe Tyr Glu Tyr Tyr Arg Asn Ser Ser 
            180                 185                 190         


Lys His Gln Glu Tyr Val Asn Asn Ile Phe Glu Ala Phe Asp Lys Leu 
        195                 200                 205             


Tyr Ser Asn Ser His Glu Asp Ile Asn Asn Leu Phe Leu Glu Ile Thr 
    210                 215                 220                 


Lys Asp Ser Asn Asp Arg Asn Ile Arg Lys Ile Arg Glu Ala Tyr His 
225                 230                 235                 240 


Glu Ile Leu Asn Lys Asn Lys Thr Glu Phe Gly Glu Glu Leu Tyr Lys 
                245                 250                 255     


Lys Ile Gln Asp Ser Ile Ser Asn Phe Asp Lys Leu Leu Glu Ile Glu 
            260                 265                 270         


Pro Glu Ile Lys Glu Leu Thr Lys Ser Gln Ile Phe Tyr Lys Tyr Tyr 
        275                 280                 285             


Ile Asp Lys Val Asn Leu Asp Glu Thr Ser Thr Lys His Cys Phe Cys 
    290                 295                 300                 


His Leu Val Glu Ile Glu Val Asn Gln Leu Leu Arg Asn Tyr Val Tyr 
305                 310                 315                 320 


Ser Lys Arg Asn Ile Ser Lys Glu Lys Leu Lys Asn Ile Phe Glu Tyr 
                325                 330                 335     


Cys Lys Leu Lys Asn Leu Ile Lys Asn Lys Leu Val Asn Lys Leu Asn 
            340                 345                 350         


Asn Tyr Ile Arg Asn Cys Gly Lys Tyr Asn Gly Tyr Ile Ser Asn Asn 
        355                 360                 365             


Asp Val Ile Asn Ser Glu Lys Ile Ser Glu Ile Arg Thr Lys Glu Ala 
    370                 375                 380                 


Phe Leu Arg Ser Ile Ile Gly Val Ser Ser Ser Ala Tyr Phe Ser Leu 
385                 390                 395                 400 


Arg Asn Ile Leu Asn Thr Asp Asn Thr Gln Asp Ile Thr Asn Lys Val 
                405                 410                 415     


Asp Lys Glu Val Asp Lys Leu Tyr Gln Glu Asn Lys Lys Ile Glu Leu 
            420                 425                 430         


Glu Glu Arg Leu Lys Leu Phe Phe Gly Asn His Phe Asp Ile Asn Asn 
        435                 440                 445             


Gln Gln Glu Ile Lys Ala Phe Leu Met Asn Ile Asp Lys Ile Ile Ser 
    450                 455                 460                 


Ser Ile Arg His Glu Ile Ile His Phe Lys Met Glu Ala Asn Val Gln 
465                 470                 475                 480 


Asn Ile Phe Asp Phe Asn Asn Ile Asn Leu Gly Asn Lys Ala Lys Asn 
                485                 490                 495     


Ile Phe Ser Asn Glu Ile Asn Glu Glu Lys Ile Lys Phe Lys Ile Phe 
            500                 505                 510         


Lys Gln Leu Asn Ser Ala Asn Val Phe Asp Tyr Leu Ser Asp Glu Asn 
        515                 520                 525             


Ile Thr Glu Tyr Met Gly Lys Ala Val Phe Ser Phe Thr Asn Arg Asn 
    530                 535                 540                 


Ile Pro Phe Val Pro Ser Phe Thr Lys Ile Tyr Asn Lys Val Gln Asp 
545                 550                 555                 560 


Leu Ala Asn Ser Leu Glu Ile Lys Lys Trp Lys Ile Pro Asn Glu Ser 
                565                 570                 575     


Glu Gly Lys Asp Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly 
            580                 585                 590         


Lys Phe Leu Asp Glu Phe Leu Asn Glu Glu Asn Gly Ile Phe Ile Ser 
        595                 600                 605             


Ile Lys Asp Lys Ile Ile Glu Leu Asn Arg Asn Gln Asn Lys Arg Thr 
    610                 615                 620                 


Gly Phe Tyr Lys Leu Glu Lys Phe Glu Lys Ile Glu Glu Thr Asn Pro 
625                 630                 635                 640 


Lys Lys Tyr Leu Glu Ile Ile Gln Ser Leu Tyr Met Ile Asn Ile Glu 
                645                 650                 655     


Glu Ile Asp Ser Glu Gly Lys Asn Ile Phe Leu Asp Phe Ile Gln Lys 
            660                 665                 670         


Ile Phe Leu Lys Gly Phe Phe Glu Phe Ile Lys Asn Asn Tyr Asn Tyr 
        675                 680                 685             


Leu Leu Glu Leu Lys Lys Ile Gln Asp Lys Lys Asn Ile Phe Asp Arg 
    690                 695                 700                 


Lys Met Ser Glu Tyr Ile Ala Gly Glu Lys Thr Leu Glu Asp Met Glu 
705                 710                 715                 720 


Glu Ile Asn Glu Ile Ile Gln Asp Ile Lys Ile Thr Glu Ile Asp Lys 
                725                 730                 735     


Ile Leu Asn Gln Thr Asp Lys Ile Asn Cys Phe Tyr Leu Leu Leu Lys 
            740                 745                 750         


Leu Leu Asn Tyr Lys Glu Ile Thr Glu Leu Lys Gly Asn Leu Lys Lys 
        755                 760                 765             


Tyr Gln Ile Leu Ser Lys Ala Asn Val Tyr Glu Lys Glu Leu Met Leu 
    770                 775                 780                 


Leu Asn Ile Val Asn Leu Asp Asn Asn Lys Val Lys Ile Glu Asn Phe 
785                 790                 795                 800 


Lys Ile Ser Ala Glu Glu Ile Gly Lys Phe Ile Glu Lys Ile Asn Ile 
                805                 810                 815     


Glu Glu Ile Asn Lys Asn Lys Lys Ile Lys Thr Phe Glu Glu Leu Arg 
            820                 825                 830         


Thr Phe Glu Lys Ile Lys Asn Thr Gly Glu Tyr Tyr Asn Val Tyr Ser 
        835                 840                 845             


Asp Asp Lys Asn Ile Lys Asn Ile Arg Asn Leu Tyr Asn Ile Lys Lys 
    850                 855                 860                 


Tyr Gly Met Leu Asp Leu Leu Glu Arg Ile Ser Glu Lys Ala Asn Tyr 
865                 870                 875                 880 


Cys Ile Lys Lys Glu Asp Leu Lys Glu Tyr Ser Glu Leu Arg Lys Gln 
                885                 890                 895     


Leu Glu Asp Glu Lys Thr Asp Phe Tyr Lys Ile Gln Lys Asp Leu His 
            900                 905                 910         


Ser Glu Tyr Gln Lys Arg Pro Lys Asn Phe Ser Glu Lys Asn Asn Thr 
        915                 920                 925             


Lys Asp Tyr Lys Lys Tyr Lys Lys Ser Ile Arg Asn Ile Glu Lys Tyr 
    930                 935                 940                 


Val His Leu Lys 
945             


<210>  1307
<211>  1102
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1307

Met Gln Met Lys Ile Ser Lys Ile Lys Asn Ser Arg Pro Gly Ile Ser 
1               5                   10                  15      


Val Ala Glu Asn Lys Asn Glu Glu Ser Leu Ser Arg Gln Ser Leu Leu 
            20                  25                  30          


Tyr Tyr Ala Pro Val Lys Asp Gly Lys Ile Arg Leu Glu Ser Lys Asp 
        35                  40                  45              


Leu Glu Gln His Val Thr Glu Cys Asn Glu Lys Ala Gln Lys Leu Tyr 
    50                  55                  60                  


Asn Val Ile Thr Pro Glu Ile Asn Phe Tyr Arg Asp Glu Asn Arg Gln 
65                  70                  75                  80  


Lys Met Val Glu Asn Leu Ala Arg Asn Phe Asn Ala Val Ile Asn Asn 
                85                  90                  95      


Ala Leu Arg Lys Glu Glu Leu Leu Asn Pro Lys Glu Lys Lys Glu Gln 
            100                 105                 110         


Arg Val Glu Lys Glu Val Ala Phe Ile Leu Asn Leu Ser Lys Lys Ser 
        115                 120                 125             


Ile Lys Met Lys Lys Asp Val Phe Val Lys Ser Thr Asp Leu Ile Val 
    130                 135                 140                 


Lys Phe Pro Glu Asn Asn Lys Tyr Asn Lys Lys Asn Asp Lys Gly Thr 
145                 150                 155                 160 


Gly Ser Lys Glu Ala Tyr Ile Gln Lys Met Ile Ser Asp Leu Val Leu 
                165                 170                 175     


Arg Lys Leu Lys Asn Thr Leu Arg Lys Glu Val Lys Leu Glu Asn Gly 
            180                 185                 190         


Tyr Arg Met Gln Met Thr Glu Ile Ile Ile Ser Leu Met Ser Ala Ile 
        195                 200                 205             


Cys Leu Tyr Gly Asn Ala Glu Ser Phe Asp Pro Ala Ile Leu Lys Ala 
    210                 215                 220                 


Phe Phe Glu Lys Val Asp Ser Asp Tyr Thr Lys Tyr Lys Tyr Val Glu 
225                 230                 235                 240 


Gln Ile Val Lys Ser Ile Glu Ser Gln Ser Ala Lys Leu Lys Val Val 
                245                 250                 255     


Glu Lys Asp Gly Arg His Leu Leu Ile Ser Ala Asn Ala Asp His Arg 
            260                 265                 270         


Lys Lys Lys Tyr Val Phe Glu Phe Met Arg Met Tyr Ala Ala Ala Asp 
        275                 280                 285             


Glu Lys Glu Lys Arg Glu Leu Thr Glu His Ile Gln Asp Leu Ile Gly 
    290                 295                 300                 


Leu Tyr Leu Cys Gly Lys Ala Gly Tyr Glu Asn Ala Glu Asn Arg Phe 
305                 310                 315                 320 


Ser Asp Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu 
                325                 330                 335     


Ile Leu Asn Glu Leu Glu Lys Pro Glu Asn Leu Ser Gln Lys Lys Lys 
            340                 345                 350         


Glu Asn Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg 
        355                 360                 365             


Ala Ala Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly 
    370                 375                 380                 


Glu Ile Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile 
385                 390                 395                 400 


Glu Tyr Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn 
                405                 410                 415     


Lys Asp Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp 
            420                 425                 430         


Lys Glu Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys 
        435                 440                 445             


Gly Val Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly 
    450                 455                 460                 


Glu Pro Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val 
465                 470                 475                 480 


Ser Gly Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg 
                485                 490                 495     


Glu Met Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala 
            500                 505                 510         


Val Thr Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu 
        515                 520                 525             


Leu Met Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu 
    530                 535                 540                 


Arg Gln Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr 
545                 550                 555                 560 


Ala Asp Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg 
                565                 570                 575     


Phe Arg Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp 
            580                 585                 590         


Leu Tyr Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr 
        595                 600                 605             


Phe His Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp 
    610                 615                 620                 


Leu Ala Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu 
625                 630                 635                 640 


Phe Arg Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val 
                645                 650                 655     


Glu Val Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr 
            660                 665                 670         


Arg Ala Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu 
        675                 680                 685             


Leu Pro Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg 
    690                 695                 700                 


Leu Met Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala 
705                 710                 715                 720 


Leu Phe Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu 
                725                 730                 735     


Gln Lys Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile 
            740                 745                 750         


Glu Lys Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp 
        755                 760                 765             


Glu Ser Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe 
    770                 775                 780                 


Gly Ala Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser 
785                 790                 795                 800 


Asp Ile Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn 
                805                 810                 815     


Lys Lys Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile 
            820                 825                 830         


Arg Glu Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg 
        835                 840                 845             


Thr Pro Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg 
    850                 855                 860                 


Ala Asp Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr 
865                 870                 875                 880 


Phe Asn Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe 
                885                 890                 895     


Ile Asn Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr 
            900                 905                 910         


Leu Gln Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp 
        915                 920                 925             


Cys Val Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr 
    930                 935                 940                 


Leu Glu Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn 
945                 950                 955                 960 


Val Met Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu 
                965                 970                 975     


Ser Gly Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu 
            980                 985                 990         


Lys Ala Leu Tyr Ser Phe Cys Lys  Gln Lys Phe Lys Val  Asp Gly Lys 
        995                 1000                 1005             


Glu Tyr  Met Ala Gly Ile Tyr  Tyr Asp Gly Glu Asn  Leu Ile Pro 
    1010                 1015                 1020             


Asn Arg  Asn Ile Ile Arg Ala  Asn Met Tyr Gly Asn  Thr Ser Cys 
    1025                 1030                 1035             


Leu Lys  Pro Cys Met Asp Arg  Ile Thr Leu Lys Glu  Ile Arg Thr 
    1040                 1045                 1050             


Met Tyr  Ala Asp Gln Asn Lys  Leu Asp Leu Val Leu  Lys Glu Gly 
    1055                 1060                 1065             


Val Cys  His Thr Glu Glu Glu  Gln Lys Ala Tyr Arg  Glu Tyr Gln 
    1070                 1075                 1080             


Asn Glu  Lys Asn Arg Ile Glu  Leu Phe Asp Val Cys  Thr Tyr Thr 
    1085                 1090                 1095             


Gln Ile  Leu Asn 
    1100         


<210>  1308
<211>  944
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1308

Met Lys Ile Thr Lys Ile Asp Gly Ile Ser His Lys Lys Tyr Ile Lys 
1               5                   10                  15      


Glu Gly Lys Leu Val Lys Ser Thr Ser Glu Glu Asn Lys Thr Asp Glu 
            20                  25                  30          


Arg Leu Ser Glu Leu Leu Thr Ile Arg Leu Asp Thr Tyr Ile Lys Asn 
        35                  40                  45              


Pro Asp Asn Ala Ser Glu Glu Glu Asn Arg Ile Arg Arg Glu Asn Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Val Leu His Leu Lys Asp Ser Val Leu 
65                  70                  75                  80  


Tyr Leu Lys Asn Arg Asn Glu Lys Asn Ala Val Gln Asp Lys Asn Tyr 
                85                  90                  95      


Ser Glu Glu Asp Ile Ser Glu Tyr Asp Leu Lys Asn Lys Asn Ser Phe 
            100                 105                 110         


Ser Val Leu Lys Lys Ile Leu Leu Asn Glu Asp Ile Asn Ser Glu Glu 
        115                 120                 125             


Leu Glu Ile Phe Arg Lys Asp Val Glu Ala Lys Leu Asn Lys Ile Asn 
    130                 135                 140                 


Ser Leu Lys Tyr Ser Phe Glu Glu Asn Lys Ala Asn Tyr Gln Lys Ile 
145                 150                 155                 160 


Asn Glu Asn Asn Val Glu Lys Val Gly Gly Arg Ser Lys Arg Asn Ile 
                165                 170                 175     


Ile Tyr Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asn Asp Tyr Ile Asn 
            180                 185                 190         


Asn Val Gln Glu Ala Phe Asp Lys Leu Tyr Lys Lys Glu Asp Ile Glu 
        195                 200                 205             


Lys Leu Phe Phe Leu Ile Glu Asn Ser Lys Lys His Glu Lys Tyr Lys 
    210                 215                 220                 


Ile Arg Glu Tyr Tyr His Lys Ile Ile Gly Arg Lys Asn Asp Lys Glu 
225                 230                 235                 240 


Asn Phe Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Ile 
                245                 250                 255     


Lys Glu Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser 
            260                 265                 270         


Gln Val Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Lys 
        275                 280                 285             


Asn Ile Lys Tyr Ala Phe Cys His Phe Val Glu Ile Glu Met Ser Lys 
    290                 295                 300                 


Leu Leu Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp 
305                 310                 315                 320 


Lys Val Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu 
                325                 330                 335     


Asn Lys Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys 
            340                 345                 350         


Tyr Asn Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile 
        355                 360                 365             


Ala Arg Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val 
    370                 375                 380                 


Ser Ser Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn 
385                 390                 395                 400 


Glu Asn Asp Ile Thr Gly Arg Met Arg Gly Lys Thr Val Lys Asn Asn 
                405                 410                 415     


Lys Gly Glu Glu Lys Tyr Val Ser Gly Glu Val Asp Lys Ile Tyr Asn 
            420                 425                 430         


Glu Asn Lys Gln Asn Glu Val Lys Glu Asn Leu Lys Met Phe Tyr Ser 
        435                 440                 445             


Tyr Asp Phe Asn Met Asp Asn Lys Asn Glu Ile Glu Asp Phe Phe Ala 
    450                 455                 460                 


Asn Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe 
465                 470                 475                 480 


Asn Leu Glu Leu Glu Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Val 
                485                 490                 495     


Pro Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys 
            500                 505                 510         


Lys Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe 
        515                 520                 525             


Arg Tyr Leu Glu Lys Tyr Lys Ile Leu Asn Tyr Leu Lys Arg Thr Arg 
    530                 535                 540                 


Phe Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys 
545                 550                 555                 560 


Leu Tyr Ser Arg Ile Asp Asp Leu Lys Asn Ser Leu Gly Ile Tyr Trp 
                565                 570                 575     


Lys Thr Pro Lys Thr Asn Asp Asp Asn Lys Thr Lys Glu Ile Ile Asp 
            580                 585                 590         


Ala Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Glu Phe Leu Asn 
        595                 600                 605             


Tyr Phe Met Ser Asn Asn Gly Asn Phe Phe Glu Ile Ser Lys Glu Ile 
    610                 615                 620                 


Ile Glu Leu Asn Lys Asn Asp Lys Arg Asn Leu Lys Thr Gly Phe Tyr 
625                 630                 635                 640 


Lys Leu Gln Lys Phe Glu Asp Ile Gln Glu Lys Thr Pro Lys Glu Tyr 
                645                 650                 655     


Leu Ala Asn Ile Gln Ser Leu Tyr Met Ile Asn Ala Gly Asn Gln Asp 
            660                 665                 670         


Glu Glu Glu Lys Asp Thr Tyr Ile Asp Phe Ile Gln Lys Ile Phe Leu 
        675                 680                 685             


Lys Gly Phe Met Thr Tyr Leu Ala Asn Asn Gly Arg Phe Ser Leu Ile 
    690                 695                 700                 


Tyr Ile Gly Ser Asp Glu Glu Thr Ser Thr Ser Leu Ala Glu Lys Lys 
705                 710                 715                 720 


Gln Glu Phe Asp Lys Phe Leu Lys Lys Tyr Glu Gln Asn Asn Asn Ile 
                725                 730                 735     


Glu Ile Pro His Glu Ile Asn Glu Phe Val Arg Glu Ile Lys Leu Gly 
            740                 745                 750         


Lys Ile Leu Lys Tyr Thr Glu Ser Leu Asn Met Phe Tyr Leu Ile Leu 
        755                 760                 765             


Lys Leu Leu Asn His Lys Glu Leu Thr Asn Leu Lys Gly Ser Leu Glu 
    770                 775                 780                 


Lys Tyr Gln Ser Ala Asn Lys Glu Glu Ala Phe Ser Asp Gln Leu Glu 
785                 790                 795                 800 


Leu Ile Asn Leu Leu Asn Leu Asp Asn Asn Arg Val Thr Glu Asp Phe 
                805                 810                 815     


Glu Leu Glu Ala Asp Glu Ile Gly Lys Phe Leu Asp Phe Asn Gly Asn 
            820                 825                 830         


Lys Ile Lys Asp Arg Lys Glu Leu Lys Lys Phe Asp Thr Asn Lys Ile 
        835                 840                 845             


Tyr Phe Asp Gly Glu Asn Ile Ile Lys His Arg Ala Phe Tyr Asn Ile 
    850                 855                 860                 


Lys Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ser Asp Lys Ala 
865                 870                 875                 880 


Lys Tyr Lys Ile Ser Ile Glu Glu Leu Lys Asn Tyr Ser Asn Lys Lys 
                885                 890                 895     


Asn Glu Ile Glu Lys Asn His Thr Thr Gln Glu Asn Leu His Arg Lys 
            900                 905                 910         


Tyr Ala Arg Pro Thr Ser Pro His Arg Ala Gln Arg Cys Asn Cys Asn 
        915                 920                 925             


Arg Gln Leu His Gln Asn Thr Arg Met Gly Gln Lys Phe Pro Thr Arg 
    930                 935                 940                 


<210>  1309
<211>  984
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1309

Met Lys Val Thr Lys Val Gly Gly Ile Ser His Lys Lys Tyr Thr Ser 
1               5                   10                  15      


Glu Gly Arg Leu Val Lys Ser Glu Ser Glu Glu Asn Arg Thr Asp Glu 
            20                  25                  30          


Arg Leu Ser Ala Leu Leu Asn Met Arg Leu Asp Met Tyr Ile Lys Asn 
        35                  40                  45              


Pro Ser Asn Thr Glu Thr Lys Glu Asn Lys Lys Arg Ile Gly Lys Leu 
    50                  55                  60                  


Lys Lys Phe Phe Ser Asn Lys Met Val Tyr Leu Lys Asp Asn Thr Leu 
65                  70                  75                  80  


Ser Leu Lys Asn Gly Lys Lys Glu Asn Ile Asp Arg Glu Tyr Ser Glu 
                85                  90                  95      


Thr Asp Ile Ser Glu Tyr Asp Val Arg Asp Ser Lys Asn Phe Ala Val 
            100                 105                 110         


Leu Lys Lys Ile Tyr Leu Asn Glu Asn Val Asn Ser Glu Glu Leu Glu 
        115                 120                 125             


Val Phe Arg Lys Asp Ile Lys Lys Lys Leu Asn Lys Ile Asn Ser Leu 
    130                 135                 140                 


Lys Tyr Ser Phe Glu Lys Asn Lys Ala Asn Tyr Gln Lys Ile Asn Glu 
145                 150                 155                 160 


Asn Asn Ile Glu Lys Val Glu Gly Lys Ser Lys Arg Asn Ile Ile Tyr 
                165                 170                 175     


Asp Tyr Tyr Arg Glu Ser Ala Lys Arg Asp Ala Tyr Val Ser Asn Val 
            180                 185                 190         


Lys Glu Ala Phe Asp Lys Leu Tyr Lys Glu Glu Asp Ile Ala Lys Leu 
        195                 200                 205             


Val Leu Lys Ile Glu Asn Leu Thr Lys Leu Glu Lys Ser Lys Ile Arg 
    210                 215                 220                 


Glu Phe Tyr His Glu Ile Ile Gly Arg Lys Asn Asp Lys Glu Asn Phe 
225                 230                 235                 240 


Ala Lys Ile Ile Tyr Glu Glu Ile Gln Asn Val Asn Asn Met Lys Glu 
                245                 250                 255     


Leu Ile Glu Lys Val Pro Asp Met Ser Glu Leu Lys Lys Ser Gln Val 
            260                 265                 270         


Phe Tyr Lys Tyr Tyr Leu Asp Lys Glu Glu Leu Asn Asp Glu Asn Val 
        275                 280                 285             


Lys Tyr Val Phe Cys His Phe Val Glu Ile Glu Met Ser Lys Leu Leu 
    290                 295                 300                 


Lys Asn Tyr Val Tyr Lys Lys Pro Ser Asn Ile Ser Asn Asp Lys Val 
305                 310                 315                 320 


Lys Arg Ile Phe Glu Tyr Gln Ser Leu Lys Lys Leu Ile Glu Asn Lys 
                325                 330                 335     


Leu Leu Asn Lys Leu Asp Thr Tyr Val Arg Asn Cys Gly Lys Tyr Asn 
            340                 345                 350         


Tyr Tyr Leu Gln Asp Gly Glu Ile Ala Thr Ser Asp Phe Ile Ala Arg 
        355                 360                 365             


Asn Arg Gln Asn Glu Ala Phe Leu Arg Asn Ile Ile Gly Val Ser Ser 
    370                 375                 380                 


Val Ala Tyr Phe Ser Leu Arg Asn Ile Leu Glu Thr Glu Asn Lys Asp 
385                 390                 395                 400 


Asp Ile Thr Gly Lys Met Arg Gly Lys Thr Arg Ile Glu Ser Lys Thr 
                405                 410                 415     


Gly Glu Glu Lys Tyr Ile Pro Gly Glu Val Asp Gln Ile Tyr Tyr Glu 
            420                 425                 430         


Asn Lys Gln Asn Glu Val Lys Asn Lys Leu Lys Met Phe Tyr Gly Tyr 
        435                 440                 445             


Asp Phe Asp Met Asp Asn Lys Lys Glu Ile Glu Asp Phe Phe Ala Asn 
    450                 455                 460                 


Ile Asp Glu Ala Ile Ser Ser Ile Arg His Gly Ile Val His Phe Asn 
465                 470                 475                 480 


Leu Asp Leu Asp Gly Lys Asp Ile Phe Ala Phe Lys Asn Ile Val Pro 
                485                 490                 495     


Ser Glu Ile Ser Lys Lys Met Phe Gln Asn Glu Ile Asn Glu Lys Lys 
            500                 505                 510         


Leu Lys Leu Lys Ile Phe Arg Gln Leu Asn Ser Ala Asn Val Phe Arg 
        515                 520                 525             


Tyr Leu Glu Lys Asp Arg Ile Leu Asp Tyr Leu Arg Ser Thr Arg Phe 
    530                 535                 540                 


Glu Phe Val Asn Lys Asn Ile Pro Phe Val Pro Ser Phe Thr Lys Leu 
545                 550                 555                 560 


Tyr Asp Arg Ile Asp Asp Leu Lys Ile Ser Leu Asn Ile Tyr Trp Lys 
                565                 570                 575     


Thr Pro Lys Thr Asn Asp Asp Ile Lys Thr Lys Glu Ile Thr Asp Ala 
            580                 585                 590         


Gln Ile Tyr Leu Leu Lys Asn Ile Tyr Tyr Gly Lys Phe Leu Asp Tyr 
        595                 600                 605             


Phe Met Ser Arg Asn Gly Asn Phe Phe Glu Ile Ser Arg Glu Val Ile 
    610                 615                 620                 


Lys Leu Asn Lys Asn Asn Lys Lys Asn Val Lys Thr Gly Phe Tyr Lys 
625                 630                 635                 640 


Leu Gln Lys Phe Glu Asn Leu Glu Ala Arg Ser Pro Lys Glu Tyr Leu 
                645                 650                 655     


Ala Lys Val Gln Ser Leu Tyr Ile Ile Asn Val Ala Asn Gln Asp Glu 
            660                 665                 670         


Glu Glu Lys Asn Thr Tyr Ile Asp Phe Ile Gln Lys Val Phe Leu Lys 
        675                 680                 685             


Gly Phe Ile Thr Tyr Leu Ala Asn Asn Arg Arg Leu Ser Leu Met Tyr 
    690                 695                 700                 


Ile Gly Ser Asp Glu Glu Val Asn Asn Ser Leu Ala Glu Lys Lys Gln 
705                 710                 715                 720 


Glu Phe Asp Lys Phe Trp Arg Lys Tyr Glu Glu Asn Asn Asp Ile Glu 
                725                 730                 735     


Ile Pro Asp Glu Ile Asn Glu Phe Leu Lys Glu Ile Lys Leu Gly Lys 
            740                 745                 750         


Ile Leu Lys Asn Ser Ala Lys Leu Asn Ile Phe Tyr Leu Ile Leu Lys 
        755                 760                 765             


Leu Leu Asn Asn Lys Glu Phe Thr Asn Leu Lys Gly Asn Leu Glu Lys 
    770                 775                 780                 


Tyr His Ser Ala Asn Glu Val Asn Ile Phe Ser Asp Glu Leu Glu Leu 
785                 790                 795                 800 


Ile Asn Phe Leu Asn Leu Asp Asn Asn Lys Val Lys Glu Asp Phe Glu 
                805                 810                 815     


Phe Glu Ala Asp Glu Ile Gly Lys Phe Leu Asn Phe Asn Gly Asn Lys 
            820                 825                 830         


Ile Lys Asn Arg Glu Glu Leu Lys Lys Phe Asp Thr Thr Lys Met Tyr 
        835                 840                 845             


Phe Tyr Lys Glu Asn Ile Ile Lys Tyr Arg Ala Tyr Tyr Asn Ile Lys 
    850                 855                 860                 


Lys Tyr Gly Met Leu Asn Leu Leu Glu Lys Ile Ala Asp Lys Ala Gly 
865                 870                 875                 880 


Tyr Lys Ile Ser Ile Glu Glu Leu Lys Lys Tyr Ser Asn Lys Lys Asn 
                885                 890                 895     


Glu Ile Glu Lys Asn His Lys Met Gln Glu Asn Leu His Arg Lys Tyr 
            900                 905                 910         


Ala Arg Pro Arg Lys Asp Glu Lys Phe Thr Asp Glu Asp Tyr Glu Ser 
        915                 920                 925             


Tyr Lys Gln Ala Ile Lys Asn Ile Glu Glu Tyr Thr His Leu Lys Asn 
    930                 935                 940                 


Lys Val Glu Phe Asn Glu Leu Asn Leu Leu Gln Gly Leu Leu Leu Arg 
945                 950                 955                 960 


Ile Leu His Arg Leu Val Gly Tyr Thr Ser Ile Trp Glu Arg Asp Leu 
                965                 970                 975     


Arg Phe Arg Leu Lys Gly Glu Phe 
            980                 


<210>  1310
<211>  937
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1310

Met Arg Ile Ile Lys Pro Tyr Gly Arg Ser Val Val Glu Lys Ala Gly 
1               5                   10                  15      


Pro Gly Arg Leu Ala Arg Ala Val Ser Leu His Pro Asp Pro Ala Arg 
            20                  25                  30          


Gly Val Glu Leu Asp Asn Arg Lys Ser Val Val Glu Phe Ala Ala Ser 
        35                  40                  45              


His Asp Arg Leu Val Ile Ala Gln Trp Ile Ser Thr Ile Asp Lys Ile 
    50                  55                  60                  


Ala Arg Lys Pro Val Gly Glu Ala Ala Ala Thr Pro Gln Gln Ala Glu 
65                  70                  75                  80  


Phe Arg Arg Arg Leu Gly Asp Ala Ala Trp Thr Leu Ile Glu Arg Arg 
                85                  90                  95      


Ala Leu Leu Thr Gly Leu Asn Asp Pro Ala Val Lys Ala Arg Leu Arg 
            100                 105                 110         


Arg Leu Trp Glu Phe Lys Ile Ala Pro Tyr Lys Thr Ala Arg Ala Val 
        115                 120                 125             


Ala Lys Thr Gly Thr Arg Pro Pro Arg Leu Lys Gly Trp Trp Phe Arg 
    130                 135                 140                 


Arg Phe Ala Gly Asp Val Glu Glu Val Asp Lys Val Asp Ala Asp Ala 
145                 150                 155                 160 


Val Ala Leu Ala Ile His Glu His Leu Tyr Ser Ala Gln Tyr Gln Met 
                165                 170                 175     


Arg Val Asp Asp Arg Thr Arg Leu Ser Gly Leu Ile Ala Ala Arg Ala 
            180                 185                 190         


Glu Ser Ile Ala Gly Asn Val Leu Gln Pro His Ala Ala Ala Arg Asp 
        195                 200                 205             


Lys Asp Gly Gly Trp Ser Glu Asp Asp Gln Arg Arg Tyr Ala Ala Ala 
    210                 215                 220                 


Gly Asp Val Ala Arg Glu Ile Arg Ser Ala Ala Glu Ala Arg Glu Arg 
225                 230                 235                 240 


Gly Asp Gly Lys Ile Gly Pro Arg Arg Val Thr Ser Glu Val Ala Gly 
                245                 250                 255     


Ala Ala Leu Phe Glu His Tyr Ala Arg Leu Phe Arg Gly Ala Asp Gly 
            260                 265                 270         


Lys Ala Met Gly Val Ala Gln Ala Arg Asp Gln Glu Ser Gly Leu Phe 
        275                 280                 285             


Asn Leu His Met Ala Val Lys Asp Cys Tyr Ala Arg Ile Leu Lys Gly 
    290                 295                 300                 


His Gly Lys Asp Leu Ala Lys His Gly Glu Gly Arg Arg Arg Val Ser 
305                 310                 315                 320 


Thr Leu Leu Pro Pro Thr Ser Val Asp Leu Phe Arg Leu Leu Asp Ala 
                325                 330                 335     


Met Leu Asp Asn Arg Asp Leu Asn Ala Leu Val Arg Leu Gly Lys Val 
            340                 345                 350         


Ile His Tyr Glu Ser Ala Gly Ala Gly Val Asp Arg Pro Ala Asp Val 
        355                 360                 365             


Val Asp His Trp Pro Ala Asp Val Ala Asp Ser Asp Tyr Trp Thr Ser 
    370                 375                 380                 


Asp Gly Gln Ala Arg Ile Lys Arg Asn Glu Ala Leu Val Arg Val Trp 
385                 390                 395                 400 


Arg His Val Leu Ala Leu Ala Ser Arg Thr Leu Thr Asp Trp Ala Asp 
                405                 410                 415     


Pro Lys Gly Met Ile Gly Gly Asp Ile Leu Leu Lys Asp Ser Val Glu 
            420                 425                 430         


Thr Ala Ile Ala Asn Phe Asp Ala Glu Ser Tyr Lys Arg Lys Ile Glu 
        435                 440                 445             


Val Leu Phe Gly Gly Arg Ala Ala Leu Phe Asp Gly Asp Gly Asp Glu 
    450                 455                 460                 


Ala Phe Glu Lys Asp Val Leu Arg Phe Ala Leu His Gly Val Ala Ala 
465                 470                 475                 480 


Leu Arg Asn Ala Ala Phe His Phe Lys Gly Val Gly Gly Phe Ala Glu 
                485                 490                 495     


Ala Leu Lys Thr Leu Gly Pro Arg Gln Asp Pro Arg Val Thr Ala Ala 
            500                 505                 510         


Val Asp Gly Leu Trp Arg Thr Asp Glu Glu Gly Arg Gly Arg Arg Leu 
        515                 520                 525             


Leu Ala Thr Met Arg Gly Ala His Phe Glu Ser Phe Phe Asp Gln Arg 
    530                 535                 540                 


Gln Asn Arg Arg Leu Ala Gln Ala Leu Ser Arg Ala Ser Glu Glu Ser 
545                 550                 555                 560 


Leu Pro Leu Pro Arg Phe Ala Val Met Leu Arg Arg Ala Glu Asn Ala 
                565                 570                 575     


Trp Asp Arg Leu Gly Leu Pro Lys Thr Ala Asn Arg Ala Asp Leu Glu 
            580                 585                 590         


Ala Pro Ala Arg His Cys Gln Tyr Val Ala Leu Lys Leu Leu Tyr Glu 
        595                 600                 605             


Arg Pro Phe Arg Ala Trp Leu Ala Glu Arg Asp Ala Ala Thr Leu Asn 
    610                 615                 620                 


Arg Phe Ile Val Cys Ala Val Glu Arg Ala Thr Lys Ala Ala Arg Met 
625                 630                 635                 640 


Leu Asn Pro Gly Ala Ser Arg Glu Leu Ala Glu Ala Ile Thr Ala Lys 
                645                 650                 655     


Ala Ala Asp Leu Gly Arg Leu Gly Asn Asp Asp Ser Val Glu Asp Phe 
            660                 665                 670         


Phe Phe Arg Leu Ser Ala Glu Thr Ala Gly Glu Ala Arg Val Gln Arg 
        675                 680                 685             


Gly Tyr Glu Ser Asp Ala Glu Asn Ala Arg Ala Gln Ala Ser His Ile 
    690                 695                 700                 


Glu Asn Leu Lys Ala Asp Leu Val Ala Leu Ala Phe Arg Asp Tyr Leu 
705                 710                 715                 720 


Gln Lys Ala Asp Phe Glu Phe Ala Leu Lys Leu Arg Gly Asp Glu Pro 
                725                 730                 735     


Leu Pro Thr Lys Pro Met Cys Ala Leu Asp Glu Ala Asp Phe Val Glu 
            740                 745                 750         


Gly Glu Ala Ser Ser Ala Glu Pro Pro Cys Glu Leu Tyr Phe Leu Leu 
        755                 760                 765             


His Leu Val Pro Val Asp Glu Val Gly Lys Leu Leu His Gln Leu Arg 
    770                 775                 780                 


Lys Trp Gln Ile Leu Ala Pro Pro Ala Pro Ala Ala Thr Gly Gly Pro 
785                 790                 795                 800 


Thr Thr Ala Ala Thr Val Ala Glu Ile Arg Leu Ala Leu Glu Leu Tyr 
                805                 810                 815     


Leu Asp Met His Asp Ala Lys Phe Glu Gly Gly Ala Ala Leu Val Gly 
            820                 825                 830         


Val Glu Pro Phe Lys Arg Leu Phe Glu Gly Asp Gly Leu Phe Gly Arg 
        835                 840                 845             


Ile Phe Glu Arg Pro Ala Gly Asp Arg Pro Gly Ala Glu Asp Asp Arg 
    850                 855                 860                 


Arg Leu Pro Arg Arg Gly Leu Arg Glu Ile Met Arg Phe Gly His Leu 
865                 870                 875                 880 


Arg Pro Leu Leu Pro Ile Phe Asp Lys Gln Pro Ile Arg Ala Asp Glu 
                885                 890                 895     


Val Ala Ala Tyr Leu Asp Ala Glu Gln Val Pro Asp Gly Gly Lys Ser 
            900                 905                 910         


Glu Ile Ala Arg Arg Gln Glu Arg Arg Glu Ala Leu His Glu Lys Trp 
        915                 920                 925             


Ala Arg Arg Arg Arg Glu Phe Ser Asp 
    930                 935         


<210>  1311
<211>  1107
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1311

Met Lys Leu Ser Lys Glu Lys His Thr Arg Ser Ala Val Ala Asn Asn 
1               5                   10                  15      


Gly Asp Ile Lys Ser Ala Glu Val Asn Asn Gly Asn Thr Lys Ser Glu 
            20                  25                  30          


Glu Val Asn Asn Gly Asp Ile Arg Ser Ala Val Ala Asn Glu Glu Gln 
        35                  40                  45              


Asn Ile Gly Gly Ile Leu Tyr Arg Phe Pro Gly Lys Ser Ile Asp Gly 
    50                  55                  60                  


Val Lys Asp Gln Met Leu Arg Arg Asp Lys Glu Val Lys Lys Leu Tyr 
65                  70                  75                  80  


Asn Val Phe Asn Gln Ile Gln Val Gly Thr Lys Pro Lys Lys Trp Asn 
                85                  90                  95      


Asn Asp Glu Lys Leu Ser Pro Glu Glu Asn Glu Arg Arg Ala Gln Gln 
            100                 105                 110         


Lys Asn Ile Lys Met Lys Asn Tyr Lys Trp Arg Glu Ala Cys Ser Lys 
        115                 120                 125             


Tyr Val Glu Ser Ser Gln Arg Ile Ile Asn Asp Val Ile Phe Tyr Ser 
    130                 135                 140                 


Tyr Arg Lys Ala Glu Asn Lys Leu Arg Tyr Met Arg Lys Asn Glu Asp 
145                 150                 155                 160 


Ile Leu Lys Lys Met Gln Glu Ala Glu Lys Leu Ser Lys Phe Ser Gly 
                165                 170                 175     


Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr Leu Arg Lys Ser Leu Val 
            180                 185                 190         


Val Ser Lys Tyr Asp Thr Gln Glu Phe Asp Ser Val Ala Ala Met Val 
        195                 200                 205             


Val Phe Leu Glu Cys Ile Gly Lys Asn Asn Ile Ser Asp His Glu Arg 
    210                 215                 220                 


Glu Ile Val Cys Lys Leu Leu Glu Leu Ile Arg Lys Asp Phe Ser Lys 
225                 230                 235                 240 


Leu Asp Pro Asn Val Lys Gly Ser Gln Gly Ala Asn Ile Val Arg Ser 
                245                 250                 255     


Val Arg Asn Gln Asn Met Ile Val Gln Pro Gln Gly Asp Arg Phe Leu 
            260                 265                 270         


Phe Pro Gln Val Tyr Ala Lys Glu Asn Glu Thr Val Thr Asn Lys Asn 
        275                 280                 285             


Val Glu Lys Glu Gly Leu Asn Glu Phe Leu Leu Asn Tyr Ala Asn Leu 
    290                 295                 300                 


Asp Asp Glu Lys Arg Ala Glu Ser Leu Arg Lys Leu Arg Arg Ile Leu 
305                 310                 315                 320 


Asp Val Tyr Phe Ser Ala Pro Asn His Tyr Glu Lys Asp Met Asp Ile 
                325                 330                 335     


Thr Leu Ser Asp Asn Ile Glu Lys Glu Lys Phe Asn Val Trp Glu Lys 
            340                 345                 350         


His Glu Cys Gly Lys Lys Glu Thr Gly Leu Phe Val Asp Ile Pro Asp 
        355                 360                 365             


Val Leu Met Glu Ala Glu Ala Glu Asn Ile Lys Leu Asp Ala Val Val 
    370                 375                 380                 


Glu Lys Arg Glu Arg Lys Val Leu Asn Asp Arg Val Arg Lys Gln Asn 
385                 390                 395                 400 


Ile Ile Cys Tyr Arg Tyr Thr Arg Ala Val Val Glu Lys Tyr Asn Ser 
                405                 410                 415     


Asn Glu Pro Leu Phe Phe Glu Asn Asn Ala Ile Asn Gln Tyr Trp Ile 
            420                 425                 430         


His His Ile Glu Asn Ala Val Glu Arg Ile Leu Lys Asn Cys Lys Ala 
        435                 440                 445             


Gly Lys Leu Phe Lys Leu Arg Lys Gly Tyr Leu Ala Glu Lys Val Trp 
    450                 455                 460                 


Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys Tyr Ile Ala Leu Gly Lys 
465                 470                 475                 480 


Ala Val Tyr Asn Phe Ala Leu Asp Asp Ile Trp Lys Asp Lys Lys Asn 
                485                 490                 495     


Lys Glu Leu Gly Ile Val Asp Glu Arg Ile Arg Asn Gly Ile Thr Ser 
            500                 505                 510         


Phe Asp Tyr Glu Met Ile Lys Ala His Glu Asn Leu Gln Arg Glu Leu 
        515                 520                 525             


Ala Val Asp Ile Ala Phe Ser Val Asn Asn Leu Ala Arg Ala Val Cys 
    530                 535                 540                 


Asp Met Ser Asn Leu Gly Asn Lys Glu Ser Asp Phe Leu Leu Trp Lys 
545                 550                 555                 560 


Arg Asn Asp Ile Ala Asp Lys Leu Lys Asn Lys Asp Asp Met Ala Ser 
                565                 570                 575     


Val Ser Ala Val Leu Gln Phe Phe Gly Gly Lys Ser Ser Trp Asp Ile 
            580                 585                 590         


Asn Ile Phe Lys Glu Ala Tyr Lys Gly Lys Lys Lys Tyr Asn Tyr Glu 
        595                 600                 605             


Val Arg Phe Ile Asp Asp Leu Arg Lys Ala Ile Tyr Cys Ala Arg Asn 
    610                 615                 620                 


Glu Asn Phe His Phe Lys Thr Ala Leu Val Asn Asp Glu Lys Trp Asn 
625                 630                 635                 640 


Thr Glu Leu Phe Gly Lys Ile Phe Glu Arg Glu Thr Glu Phe Cys Leu 
                645                 650                 655     


Asn Val Glu Lys Asp Arg Phe Tyr Ser Asn Asn Leu Tyr Met Phe Tyr 
            660                 665                 670         


Gln Val Ser Glu Leu Arg Asn Met Leu Asp His Leu Tyr Ser Arg Ser 
        675                 680                 685             


Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn Ser Val Ile Val Arg 
    690                 695                 700                 


Thr Ala Phe Pro Glu Tyr Ile Thr Asn Val Leu Gly Tyr Gln Lys Pro 
705                 710                 715                 720 


Gly Tyr Asp Ala Asp Thr Leu Gly Lys Trp Tyr Ser Ala Cys Tyr Tyr 
                725                 730                 735     


Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu Gln Ser Asp Arg Ala 
            740                 745                 750         


Leu Gln Leu Phe Glu Lys Ser Val Lys Thr Leu Ser Trp Asp Asp Lys 
        755                 760                 765             


Lys Gln Gln Arg Ala Val Asp Asn Phe Lys Asp His Phe Ser Asp Ile 
    770                 775                 780                 


Lys Ser Ala Cys Thr Ser Leu Ala Gln Val Cys Gln Ile Tyr Met Thr 
785                 790                 795                 800 


Glu Tyr Asn Gln Gln Asn Asn Gln Ile Lys Lys Val Arg Ser Ser Asn 
                805                 810                 815     


Asp Ser Ile Phe Asp Gln Pro Val Tyr Gln His Tyr Lys Val Leu Leu 
            820                 825                 830         


Lys Lys Ala Ile Ala Asn Ala Phe Ala Asp Tyr Leu Lys Asn Asn Lys 
        835                 840                 845             


Asp Leu Phe Gly Phe Ile Gly Lys Pro Phe Lys Ala Asn Glu Ile Arg 
    850                 855                 860                 


Glu Ile Asp Lys Glu Gln Phe Leu Pro Asp Trp Thr Ser Arg Lys Tyr 
865                 870                 875                 880 


Glu Ala Leu Cys Ile Glu Val Ser Gly Ser Gln Glu Leu Gln Lys Trp 
                885                 890                 895     


Tyr Ile Val Gly Lys Phe Leu Asn Ala Met Ser Leu Asn Leu Met Val 
            900                 905                 910         


Gly Ser Met Arg Ser Tyr Ile Gln Tyr Val Thr Asp Ile Lys Arg Arg 
        915                 920                 925             


Ala Ala Ser Ile Gly Asn Glu Leu His Val Ser Val Gln Asp Val Glu 
    930                 935                 940                 


Lys Val Glu Lys Trp Val Gln Val Ile Glu Val Cys Ser Leu Leu Ala 
945                 950                 955                 960 


Ser Arg Thr Ser Asn Gln Phe Glu Asp Tyr Phe Asn Asp Lys Asp Asp 
                965                 970                 975     


Tyr Ala Arg Tyr Leu Lys Ser Tyr Val Asp Phe Ser Asn Val Asp Met 
            980                 985                 990         


Pro Ser Glu Tyr Ser Ala Leu Val  Asp Phe Ser Asn Glu  Glu Gln Ser 
        995                 1000                 1005             


Asp Leu  Tyr Val Asp Pro Lys  Asn Pro Lys Val Asn  Arg Asn Ile 
    1010                 1015                 1020             


Val His  Ser Lys Leu Phe Ala  Ala Asp His Ile Leu  Arg Asp Ile 
    1025                 1030                 1035             


Val Glu  Pro Val Ser Lys Asp  Asn Ile Glu Glu Phe  Tyr Ser Gln 
    1040                 1045                 1050             


Lys Ala  Glu Ile Ala Tyr Cys  Lys Ile Lys Gly Lys  Glu Ile Thr 
    1055                 1060                 1065             


Ala Glu  Glu Gln Lys Ala Val  Leu Lys Tyr Gln Lys  Leu Lys Asn 
    1070                 1075                 1080             


Arg Val  Glu Leu Arg Asp Ile  Val Glu Tyr Gly Glu  Ile Ile Asn 
    1085                 1090                 1095             


Glu Leu  Leu Gly Gln Leu Ile  Asn Trp 
    1100                 1105         


<210>  1312
<211>  1156
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1312

Met Lys Ile Thr Lys Asn Thr Lys Asn Gly Lys Leu Glu Phe Tyr Arg 
1               5                   10                  15      


Asp Val Lys Glu Gly Gly Leu Arg Asp Pro Lys Ser Lys Thr Ile Trp 
            20                  25                  30          


Thr Ser Glu Thr Ile Lys Arg Leu Asp Ile Asn Lys Ser Leu Lys Gly 
        35                  40                  45              


Arg Ile Leu Ala Tyr Gly Thr Ser Leu Gly Ser Ser Asn Pro Tyr Ser 
    50                  55                  60                  


Val Phe Val Asp Ser Leu Ile Arg Glu Asn Lys Glu Ile Ser Leu Ser 
65                  70                  75                  80  


Glu Leu Lys Arg Glu Gln Cys Lys Lys Glu Asn Val Gln Lys Tyr Leu 
                85                  90                  95      


Ser Ala Tyr Gly Arg Met Ile Asn His Gly Ala Glu Glu Asn Thr Ser 
            100                 105                 110         


Leu Gly Asn Leu Leu Val Glu Tyr Gly Asn Gly Ala Glu Ile Ser Glu 
        115                 120                 125             


Ala Leu Val Gln Ile Lys Lys Gln Ile Leu Lys Leu Lys Arg His Lys 
    130                 135                 140                 


Lys Lys Ser Leu Leu Asp Ser Phe Met Asn Asn Lys Ile Pro Phe Lys 
145                 150                 155                 160 


Leu Thr Asp Gly Lys Leu Glu Pro Ala Thr Asp Lys Met Ser Arg Leu 
                165                 170                 175     


Phe Ser Leu Leu Glu Glu Asp Gly Val Asp Lys Asn Lys Phe Glu Lys 
            180                 185                 190         


Tyr Lys Thr Trp Tyr Gln Tyr Glu Val Leu Lys Glu Arg Leu Asp Leu 
        195                 200                 205             


Ile Cys Glu Glu His Phe Ser Ala Ala Glu Arg Lys Pro Arg Val Leu 
    210                 215                 220                 


Ala Lys Lys Ile Tyr Ser Ala Val Lys Leu Tyr Asn Lys Glu Lys Ala 
225                 230                 235                 240 


Asn Ser Asp Val Ile Lys Asn Lys Asp Asp Ala His Ser Leu Phe Leu 
                245                 250                 255     


Asp Glu Ile Arg Asp His Phe Arg Lys Tyr Phe Pro Val Thr Gly Lys 
            260                 265                 270         


Lys Gly Leu Ser Ser Gly Gly Asp Ser Glu Lys Leu Asn Ser Leu Ala 
        275                 280                 285             


Ser Glu Lys Asn Val Lys Tyr Tyr Tyr Ser Asp Lys Tyr Val Phe Gln 
    290                 295                 300                 


Gln Val Trp Arg Gln Ile Val Asn Gln Leu Thr Ala Gly Leu Ile Gln 
305                 310                 315                 320 


Tyr Gly Lys Leu Ser Tyr Tyr Phe His Asp Lys Glu Asn His Thr Trp 
                325                 330                 335     


Gln Glu Glu Lys Leu Asn Ser Ala Gly Met Gln Glu Ile Gln Val Arg 
            340                 345                 350         


Glu Thr Phe Lys Lys Gln Leu Phe Leu Ser Val Val Trp Ser Val Asn 
        355                 360                 365             


Lys Leu Asn Tyr Phe Phe Gln Tyr Gly Gly Glu Asn Pro Lys Met Leu 
    370                 375                 380                 


Tyr Gln Val Lys Tyr Asp Glu Asp Cys Ile Ala Gly Asp Ile Ile Glu 
385                 390                 395                 400 


Glu Leu Arg Lys Ala Asp Phe Ser Arg Phe Cys Tyr Asp Asp Pro Ile 
                405                 410                 415     


Lys Asn Asn Tyr Ile His Arg Phe Met His Gly Ile Lys Glu Glu Pro 
            420                 425                 430         


Glu Lys Phe Glu Leu Leu Phe Asp Lys Met Ser Val Ser Tyr Pro Leu 
        435                 440                 445             


Glu Glu Glu Asp Lys Asn Pro Glu Glu Ile Leu Lys Val Leu Gln Glu 
    450                 455                 460                 


Ile Asn Cys Ser Val Thr Asp Leu Arg His Ser Ile Ile His Tyr Gln 
465                 470                 475                 480 


Lys Asp Val Val Tyr Gln Glu Thr Gln Gly Pro Lys Tyr Pro Lys Ala 
                485                 490                 495     


Ser Glu Phe Leu Arg Arg Asp Ile Asp Asn Ile Glu Asn Cys Phe Leu 
            500                 505                 510         


Glu Gln Ile Arg Ser Met Ser Leu Ala Glu Tyr Tyr Pro Leu Asp Leu 
        515                 520                 525             


Leu Gln Lys Val Phe Lys Asp Cys Asn Leu Asn Phe Gln Leu Tyr Ala 
    530                 535                 540                 


Ser Gln Val Pro Met Val Pro Ser Phe Gln Lys Val Phe Gly Lys Gly 
545                 550                 555                 560 


Val Asn Leu Tyr Lys Ala Asp Gln Lys Ser Asp Ser Leu Lys Trp Tyr 
                565                 570                 575     


Met Glu Glu Arg Lys Asp Ser Glu Ala Lys Leu Ala Thr Leu Ala Tyr 
            580                 585                 590         


Arg Asn Phe Ile Gln Leu Ile Tyr Tyr His Gly Phe Leu Pro Ala Val 
        595                 600                 605             


Glu Lys Asn Asn Ala Leu Val Thr Asp Phe Ile Asn Lys Thr Val Glu 
    610                 615                 620                 


Trp Asn Lys Glu Arg Ser Leu Gln Arg Gln Ser Glu Asp Pro Gly Thr 
625                 630                 635                 640 


Lys Tyr Ile Asn Ile Ser Lys Tyr Arg Tyr Gln Gly Met Pro Glu Phe 
                645                 650                 655     


Gln Asn Lys Ser Leu Leu Glu Tyr Met Ser Glu Leu Gln Arg Asp Gln 
            660                 665                 670         


Ser Asn Lys Glu Lys Glu Asp Ser Gln Ala Gly Val Pro Glu Asp Lys 
        675                 680                 685             


Lys Lys His Tyr Tyr Thr Lys Phe Ile Gln Asp Ile Phe Ala Phe Ser 
    690                 695                 700                 


Phe Gly Ser Phe Leu Asn Ser Lys Leu Asn Glu Cys Arg Glu Asp Leu 
705                 710                 715                 720 


Leu Gln Pro Arg Tyr Gln Glu Met Lys Thr Asn Glu Asp Arg Glu Gln 
                725                 730                 735     


Arg Leu Lys Lys Leu Leu Glu Asp Leu Glu Met Lys Thr Asn Ile Lys 
            740                 745                 750         


Asn Gly Ser Pro Thr Gln Leu Ala Met Tyr Pro Phe Leu Lys Leu Leu 
        755                 760                 765             


Asp Gln Arg Gly Leu Asn Gln Leu Leu His Gln Phe Ile Arg Cys Ser 
    770                 775                 780                 


Ala Ser Val Lys Ser Gly Phe Met Gln Asp Asp Lys Ala Leu Asn Leu 
785                 790                 795                 800 


Asn Arg Glu Ile Glu Glu Leu Ile Ala Leu Val Ala Phe Thr Lys Arg 
                805                 810                 815     


Pro Leu Met Asn Thr Glu Ala Tyr Ser Lys Ala Ile Glu Met Leu Ser 
            820                 825                 830         


Glu Thr Phe Ile Glu Gly Glu Ile Lys Asp Tyr Ala Asp Leu Tyr Tyr 
        835                 840                 845             


Gln Ser Asp Gln Glu His Ser Val Leu His Arg Asn Ile Ala Tyr Met 
    850                 855                 860                 


Gly Gly Thr Gly Val Ile Ala Leu Tyr Ser Asp Val Leu Arg Asp Cys 
865                 870                 875                 880 


Tyr Arg Val Lys Lys Thr Asp Tyr Val Ala Tyr Lys Lys Ala Asn Ser 
                885                 890                 895     


Lys Glu Asn Gly Arg Gln Phe Thr Arg Ile Gly Glu Asp Gln Lys Arg 
            900                 905                 910         


Leu Gln Asp Leu His Glu Ser Leu Ile Gly Arg Tyr Asn Ser Gly Gln 
        915                 920                 925             


Ile Gln Glu Tyr Lys Lys Leu Leu Arg Lys Thr His Glu Tyr Asn Ala 
    930                 935                 940                 


Leu Lys Lys Arg Ile Thr Phe Glu Thr Met Tyr Glu Ile Tyr Gln Leu 
945                 950                 955                 960 


His Thr Glu Leu Leu Gly Arg Leu Ala Ser Phe Ala Glu Asp Trp Glu 
                965                 970                 975     


Arg Asp Met Leu Phe Leu Leu Thr Gly Leu Glu Ser Arg Gly Leu Ile 
            980                 985                 990         


Glu Asp Arg Val Glu Lys Ile Phe  Leu Lys Asp Lys Gly  Gly Val Val 
        995                 1000                 1005             


Ala Lys  Met Asn Lys Asn Leu  Lys Asp Asn Glu Lys  Leu Leu Lys 
    1010                 1015                 1020             


Ser Leu  Tyr Cys Arg Glu Asp  Gln Glu Ser Thr Asp  Phe Trp Lys 
    1025                 1030                 1035             


Thr Phe  His Val Arg Asn Ala  Val Ala His Phe Asn  His Phe Thr 
    1040                 1045                 1050             


Gln Lys  Ser Gln Ser Lys Gly  Gly Ser Val Val Tyr  Gln Arg Ser 
    1055                 1060                 1065             


Ile Glu  Glu Leu Ile Asn Arg  Ile Arg Gly Leu Leu  Ala Tyr Asp 
    1070                 1075                 1080             


Met Lys  Arg Gln Asn Ala Val  Thr Gln Ala Val Gln  Lys Ile Phe 
    1085                 1090                 1095             


Asp Lys  His Gln Met Ile Ile  Lys Phe Lys Pro Val  Thr Ile Asn 
    1100                 1105                 1110             


Ser Asp  Pro Glu Lys Trp Val  Gly Thr Trp Asn Ile  Glu Phe Gly 
    1115                 1120                 1125             


Ile Asp  Cys Ile Arg Ser Lys  Asn Ile Val His Phe  Lys Asn Leu 
    1130                 1135                 1140             


Ser Asp  Arg Ile Cys Leu Ile  Glu Ala His Asp Arg  Asn 
    1145                 1150                 1155     


<210>  1313
<211>  1126
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (698)..(750)
<223>  Xaa can be any naturally occurring amino acid

<400>  1313

Met Lys Val Ser Lys Val Lys His Thr Arg Met Ala Val Ser Ala Ala 
1               5                   10                  15      


Gln Gly Val Pro Glu Gly Ile Leu Tyr Pro Asp Pro Asn Val Lys Asn 
            20                  25                  30          


Ser Asp Gly Gln Trp Ala Lys Pro Gln Val Met Asp Ile Gly Glu His 
        35                  40                  45              


Phe Asp Thr Ile Ser Glu Asn Ala Lys Glu Leu Tyr Asn Ile Leu Asn 
    50                  55                  60                  


Pro Glu Ile Pro Lys Lys Arg Tyr Gly Lys Val His Pro Ile Leu Arg 
65                  70                  75                  80  


Ser Lys Ile Gly Gly Tyr Phe Lys Lys Leu Val Glu Phe Asn Asp Gln 
                85                  90                  95      


Asp Asn Ile Asn Val Leu Glu Glu Gln Leu Lys Phe Ile Asp Gly Cys 
            100                 105                 110         


Ser Asp Asn Met Ser Ser Tyr Phe Phe Phe Tyr Lys Asp Lys Lys Lys 
        115                 120                 125             


Pro Asn Val Lys Ala Leu Val Asn Thr Tyr Leu Arg Lys Thr Leu Arg 
    130                 135                 140                 


Lys Asn Val Lys Ser Glu Glu Gly Asp Ser Ala Lys Lys Ile Tyr Leu 
145                 150                 155                 160 


Pro Thr Val Ala Glu Lys Leu Ile Asp Ala Leu Cys Phe Asp Glu Thr 
                165                 170                 175     


Thr Thr Lys Ala Glu Arg Pro Gly Val Tyr Gln Glu Arg Ile Lys Ile 
            180                 185                 190         


Phe Arg Lys Lys Asn Asp Lys Glu Leu Lys Thr Phe Leu Lys Ser Leu 
        195                 200                 205             


Asn Asn Asp Tyr Asn Arg Thr Gln Gln Lys Ala Arg Val Ile Asn Ser 
    210                 215                 220                 


Ile Lys Lys Gln Asn Val Lys Ala Lys Val Ile Glu Lys Glu Gly Leu 
225                 230                 235                 240 


Cys Leu Leu Gln Pro Ser Phe Ala Asp His Ser Lys Lys His Val Ile 
                245                 250                 255     


Phe Asp Phe Met Leu Arg Phe Ala Val Gly Thr Glu Lys Glu Arg Ser 
            260                 265                 270         


Asn Leu Leu Asn Tyr Met Arg Gly Leu Ile Val Leu Tyr Val Cys Gly 
        275                 280                 285             


Val Asn Val Tyr Asn Gly Leu Phe Thr Asp Asp Phe Ile Leu Lys Asp 
    290                 295                 300                 


Phe Ser Ala Pro Leu Ile Ser Glu Asp Leu Val Phe Cys Glu Lys Ala 
305                 310                 315                 320 


Ser Ile Leu Leu Lys Lys Gly Lys Ala Lys Asn Gln Lys Asp Phe Leu 
                325                 330                 335     


Lys Lys Ala Tyr Glu His Glu Leu Val Glu His Tyr Gln Ala Ala Leu 
            340                 345                 350         


Lys Val Phe Glu Ala Glu Ala Val Arg Asp Leu Pro Glu Cys Val Asp 
        355                 360                 365             


Lys Lys Gln Arg Val Glu Ala Val Lys Lys Lys Ile Gln Asn Glu Ser 
    370                 375                 380                 


Phe Trp Leu Asp Phe Ile Glu Gln Glu Val Lys Gly Thr Ile Asn Leu 
385                 390                 395                 400 


Ser Arg Pro Tyr Ser Glu Tyr Lys Asn Asn Ala Leu Tyr Leu Cys Arg 
                405                 410                 415     


Lys Val Trp Lys Lys Trp Thr Ala Phe Met Ala Glu Lys Tyr Ile Asp 
            420                 425                 430         


Leu Gly Lys Ala Val Tyr His Phe Ala Met Pro Asp Met Pro Ser Asp 
        435                 440                 445             


Asn Lys Glu Pro Val Lys Tyr Gly Ile Val Arg Lys Glu Tyr Glu Asn 
    450                 455                 460                 


Gly Leu Thr Ser Phe Asp Tyr Glu Arg Ile Lys Ala Val Glu Asn Met 
465                 470                 475                 480 


Glu Arg Asn Val Ser Ile Ala Val Thr Phe Ala Val Asn Asn Phe Ser 
                485                 490                 495     


Arg Ser Val Leu Lys Asn Pro Ala Gly Asp Thr Thr Asp Val Leu Phe 
            500                 505                 510         


Leu Asn Ser Gly Gln Leu Asp Gly Ser Leu Tyr Glu Asn Lys Gly His 
        515                 520                 525             


Arg Ile Leu Arg Tyr Phe Gly Gly Ala Ser Ile Trp Ala Asp Asn Asn 
    530                 535                 540                 


Thr Val Ser Glu Ala Ala Lys Asn Arg Gly Asp Ala Leu Phe Lys Glu 
545                 550                 555                 560 


Ile Lys Glu Gln Leu Glu Ser Leu Arg Asn Gly Ser Tyr His Tyr Thr 
                565                 570                 575     


Gln Lys Phe Asp Asp Val Lys Ser Asn Ile Val Pro Ala Met Leu Asp 
            580                 585                 590         


Ser Glu Lys Ala Trp Ile Gly Pro Ile Ile Arg Lys Lys Tyr Tyr Ser 
        595                 600                 605             


Asn Asn Thr His Trp Phe Tyr Pro Glu Asp Lys Leu Asn Gly Leu Met 
    610                 615                 620                 


Val Ile Leu Tyr Lys Thr Pro Ala Val Arg Gly Asp Gln Val Pro Ala 
625                 630                 635                 640 


Phe Ser Arg Leu Tyr Asn Arg Asn Thr Leu Phe Glu Glu Glu Arg Ile 
                645                 650                 655     


Phe Thr Pro Gln Phe Arg Gly Lys Ile Asn Ser Leu Gly Asn Glu Lys 
            660                 665                 670         


Ala Glu Ile Phe Lys Gly Ala Ala Phe Phe Leu Phe Lys Glu Ile Tyr 
        675                 680                 685             


Tyr Tyr Ser Phe Leu Lys Asp Asn Cys Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    690                 695                 700                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
705                 710                 715                 720 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                725                 730                 735     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Met Glu 
            740                 745                 750         


Asp Ile Ser Glu Glu Ala Thr Leu Gly Glu Leu Ala Gln Val Ile Met 
        755                 760                 765             


Thr Asp Tyr Asn Leu Gln Asn Gln Met Lys Glu Thr Ala Gln Ile Val 
    770                 775                 780                 


Ser Thr Asn Lys Val Lys Ala Ser Lys Glu Lys Tyr Lys Ala Phe Pro 
785                 790                 795                 800 


Met Ile Leu Tyr Lys Phe Met Arg Leu Thr Phe Leu Asp Phe Leu Gly 
                805                 810                 815     


Lys Asn Lys Asp Lys Phe Gly Phe Leu Tyr Glu Cys Glu Pro Gly Glu 
            820                 825                 830         


Gln Thr Glu Gln Ile Gly Ile Lys Glu Ala Asp Phe Cys Ala Glu Asn 
        835                 840                 845             


Asp Gly Gln Arg Val Glu Leu Phe Arg Lys Leu Thr Leu Glu Glu Glu 
    850                 855                 860                 


Gly Gln Lys Ser Val Ala Pro Trp Tyr Val Leu Gly His Met Ile Pro 
865                 870                 875                 880 


Pro Ala Gln Leu Asn His Leu Tyr Gly Asp Leu Arg Ser Tyr Ile Cys 
                885                 890                 895     


Tyr Leu Arg Asn Ile Asp Arg Arg Ala Asp Gln Thr Gly Asn Asp Asn 
            900                 905                 910         


Arg Val Val Thr Asp Ala Tyr Arg Lys Glu Ala Asp Tyr Phe Glu Arg 
        915                 920                 925             


Val Leu Glu Val Leu Glu Phe Cys Arg Phe Phe Cys Gly Lys Thr Ser 
    930                 935                 940                 


Lys Gln Tyr Thr Asp Tyr Tyr Pro Lys Gly Thr Tyr Ala Gly Glu Val 
945                 950                 955                 960 


Phe Lys Tyr Val Asp Val Lys Asn Tyr Leu Gly Ala Ala Ala Asp Ala 
                965                 970                 975     


Ser Asp Glu Glu Ile Leu Ala Ala Phe Cys Asp Gln Lys Ala Gly Ile 
            980                 985                 990         


Lys Asn Pro Asp Gly Thr Asp Gln  Lys Ile Lys Ile Phe  His Asp Gly 
        995                 1000                 1005             


Glu Asn  Leu Ile Leu Asn Arg  Asn Met Val Leu Ala  Ser Leu Tyr 
    1010                 1015                 1020             


Gly Thr  Asp Arg Ile Ile Gln  Asn Ala Ala Asp Lys  Val Thr Glu 
    1025                 1030                 1035             


Asp Asp  Ile Phe Glu Tyr Tyr  Lys Leu Trp Asn Thr  Leu Met Arg 
    1040                 1045                 1050             


Glu Asn  Thr Gly Val Gln Met  Gly Glu Lys Glu Arg  Cys Glu Lys 
    1055                 1060                 1065             


Asn Arg  Glu Leu Gln Asn Arg  Lys Asn His Ile Glu  Leu Val Asp 
    1070                 1075                 1080             


Ile Lys  Ile Tyr Ser Asp Ile  Leu Asn Asp Leu Met  Ile Gln Met 
    1085                 1090                 1095             


Val Ser  Trp Ala Tyr Phe Arg  Glu Arg Asp Gln Leu  Tyr Leu Ala 
    1100                 1105                 1110             


Leu Gly  Thr Gln Tyr Leu Arg  Leu Tyr Tyr Gly Asp  His 
    1115                 1120                 1125     


<210>  1314
<211>  902
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1314

Met Lys Leu Thr Lys Val Glu Lys Ala Arg Ile Ala Val Ser Arg Glu 
1               5                   10                  15      


Lys Lys Asp Ser Gly Arg Ile Ile Leu Tyr Thr Asn Pro Glu Asp Val 
            20                  25                  30          


Lys Lys Thr Ser Val Thr Thr Met Glu Gln Gln Val Ser Lys Arg Ile 
        35                  40                  45              


Asp Gln Ala Asn Lys Leu Tyr Gln Val Phe Phe Lys Ser Val Ile Pro 
    50                  55                  60                  


Val Glu Leu Asn Lys His Phe Ala Glu Ile Ser Lys Ile Ala Ala Lys 
65                  70                  75                  80  


Cys Arg Asn Thr Glu Glu Phe Tyr Lys Lys Ala Cys Gly Tyr Ser Gly 
                85                  90                  95      


Tyr Glu Trp Thr Asp Ala Lys Gln Lys Lys Arg Thr Ser Gln Ile Ser 
            100                 105                 110         


Arg Phe Ser Tyr Thr Ser Ser Gly Lys Asn Met Tyr Val Val Met Asp 
        115                 120                 125             


Asn Phe Val Lys Glu Tyr Met Val Gln Ile Trp Gln Glu Lys Asp Phe 
    130                 135                 140                 


Arg Asn Ala Ala Val Lys Ile Leu Cys Cys Ile Cys Asp Gly Lys Lys 
145                 150                 155                 160 


Phe Ala Ser Lys Leu Glu Lys Val Lys Lys Glu Ser Pro Asp Thr Leu 
                165                 170                 175     


Lys Lys Phe Ile Glu Ile Ser Gly Lys Cys Glu Gly Asn Pro Phe Val 
            180                 185                 190         


Asp Tyr Asp Thr Ser Phe Leu Glu Lys Val Phe Thr Leu Val Ile Ser 
        195                 200                 205             


Gln Met Val Lys Asn Cys Asp Arg Lys Ser Tyr Glu Gln Asp Asp Lys 
    210                 215                 220                 


Glu Lys Ile Lys Lys Ser Ile Gln Lys Glu Ile Gln Trp Leu Ser His 
225                 230                 235                 240 


Val Gln Ser Val Thr Glu Arg Ser Phe Gly Arg Glu Gly Lys Thr Tyr 
                245                 250                 255     


Leu Leu Phe Lys Ile Arg Asn Pro Tyr Ala Thr Glu Glu Arg Leu Gln 
            260                 265                 270         


Thr Val Leu Ile Arg Met Arg Lys Thr Leu Lys Arg Gly Arg Asn Arg 
        275                 280                 285             


Asp Ile Ala Ile Val Leu Leu Gln Gly Leu Ala Gln Met Asn Gln Val 
    290                 295                 300                 


Thr Phe Thr Asp Thr Val Lys His Leu Tyr Gln Glu Glu Glu Lys Ala 
305                 310                 315                 320 


Phe Cys Asp Phe Ile Asp Ala Val Asn Arg Asp Tyr Tyr Arg Val Asn 
                325                 330                 335     


Ile Val Lys Ser Val Arg Asn Met Asp Val Lys Val Gln Pro Asp Leu 
            340                 345                 350         


Asn Asp Asn Ser Ile Leu Lys Leu Ser Gly Leu Gly Asn Ile Lys Lys 
        355                 360                 365             


Glu Ala Leu Ser Asp Thr Leu Leu Arg Tyr Ala Ala Ser Ala Asp Glu 
    370                 375                 380                 


Ser Asp Gln Val Leu Leu Asp Ile Lys Lys Leu Leu Phe Glu Tyr Phe 
385                 390                 395                 400 


Leu Pro Gly Asn Ser Lys Glu Thr Ser Lys Tyr Thr Thr Val Gln Asn 
                405                 410                 415     


Leu Trp Asn Ile Pro Tyr Leu Pro Lys Ile Phe Phe Asp Tyr Gly Phe 
            420                 425                 430         


Glu Asn Glu Asp Ser Asp Asp Asp Asn Glu Cys Ala Glu Asp Ile Glu 
        435                 440                 445             


Thr Leu Cys Asp Val Glu Pro Gln Tyr Lys Ile Asn Gln His Ser Leu 
    450                 455                 460                 


Lys Arg Arg Ile Arg Tyr Val Asn Tyr Gly Lys Tyr Leu Gln Met Thr 
465                 470                 475                 480 


Lys Asn Glu Ser Asp Arg Glu Arg Arg Tyr Trp Ile His Tyr Ile Lys 
                485                 490                 495     


Glu Phe Val Glu Lys Asn Tyr Val Asp Ser Gly Arg Thr Leu Ser Glu 
            500                 505                 510         


Lys Asn Cys Tyr Ala Ser Ser Met Met Leu Asn Cys Trp Lys Glu Ile 
        515                 520                 525             


Ile Arg Tyr Leu Cys Gly Lys Tyr Ile Asp Ile Gly Lys Ala Val Phe 
    530                 535                 540                 


His Phe Thr Asn Leu Thr Ala Met Pro Lys Pro Lys Asp Lys Ile Ile 
545                 550                 555                 560 


Tyr Gly Gln Leu Glu Glu Gln Tyr Lys Lys Gly Ile Ser Ser Phe Asp 
                565                 570                 575     


Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln Arg Asp Ile Val Gln 
            580                 585                 590         


Ser Val Val Ala Ala Ala Phe Ala Phe Ser Lys Ser Val Ile Asp Glu 
        595                 600                 605             


Thr Lys Met Glu Glu Cys Gln Glu Thr Asn Lys Glu Asp Ile Leu Phe 
    610                 615                 620                 


Leu Ser Glu Asn Val Leu Gly Ser Leu Leu Lys Glu Asn Thr Ile Lys 
625                 630                 635                 640 


Leu Ile Leu Arg Phe Tyr Gly Gly Glu Ser Ser Val Ala Gln Lys Glu 
                645                 650                 655     


Tyr Phe Asp Gln Gln Glu Ile Val Gln Glu Met Ile Ser His Leu Lys 
            660                 665                 670         


Ser Ile Arg Asn Glu Asn Phe His Tyr Leu Asp Gly Ala Lys Lys Asp 
        675                 680                 685             


Asn Pro His Lys Tyr Ala Ser Ile Leu Trp Lys Asn Asp Glu Met Ala 
    690                 695                 700                 


Tyr Gln Lys Leu Thr Lys Gln Arg Tyr Tyr Ala Asn Asn Val Gly Leu 
705                 710                 715                 720 


Phe Tyr Arg Ala Glu Glu Ile Gln Glu Leu Val Gln Glu Leu Tyr Ser 
                725                 730                 735     


Gln Lys Asn Ile Thr Glu Ala Gln Ile Pro Ala Phe Arg Thr Val Leu 
            740                 745                 750         


Lys Arg Lys Asp Leu Pro Gly Tyr Met Glu Glu Leu Gly Ile Leu Phe 
        755                 760                 765             


Pro Asp Asn Thr Gln Glu Lys Ser Lys Gly Asp Phe Glu Gly Thr Leu 
    770                 775                 780                 


Tyr Phe Leu Met Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Val Lys Asp 
785                 790                 795                 800 


Lys Ala Ala Ala Tyr Phe Phe Lys Ala Val Asp Gln Asn Lys Glu Gln 
                805                 810                 815     


Ser Lys Lys Glu Asp Lys His Thr Glu Arg Ala Ala Glu Asn Phe His 
            820                 825                 830         


Arg Tyr Val Lys Ser Leu Glu Lys Lys Tyr Asn Lys Lys Glu Ile Ser 
        835                 840                 845             


Phe Gly Thr Val Cys Gln Tyr Ile Met Met Glu Tyr Asn Gln Gln Asn 
    850                 855                 860                 


Thr Thr Lys Gln Glu Thr Glu Ile Tyr Lys His Phe Lys Met Leu Ile 
865                 870                 875                 880 


Ser Leu Cys Ile Arg Lys Ala Phe Gly Asn Tyr Ile Lys Glu Thr Tyr 
                885                 890                 895     


Arg Phe Leu Phe His Pro 
            900         


<210>  1315
<211>  957
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1315

Met Thr Glu Ser His Asn Cys Ile Cys Gly Lys Ile Glu Glu Ile Leu 
1               5                   10                  15      


Asn Glu Leu Glu Lys Pro Glu Asn Phe Leu Ser Lys Lys Lys Glu Asn 
            20                  25                  30          


Leu Lys Asn Thr Thr Val Lys Val Met Ala Leu Lys Tyr Arg Ala Ala 
        35                  40                  45              


Val Asn Tyr Leu Ala Asp Glu Val Gly Lys Thr Val Leu Gly Glu Ile 
    50                  55                  60                  


Arg Glu Lys Lys Val Arg Ser Cys Ala Asp Leu Tyr Trp Ile Glu Tyr 
65                  70                  75                  80  


Ile Asp Ser Thr Val Glu Lys Leu Leu Leu Lys Ser Arg Asn Lys Asp 
                85                  90                  95      


Gly Tyr Arg Tyr Glu Ile Gly Phe Leu Ser Lys His Ile Trp Lys Glu 
            100                 105                 110         


Trp Thr Gln Tyr Ile Ser Gly Lys Tyr Ile Glu Met Gly Lys Gly Val 
        115                 120                 125             


Tyr His Phe Ala Ile Pro Asp Leu Ser Gly Asn Leu Glu Gly Glu Pro 
    130                 135                 140                 


Ile Ser Ile Cys Glu Val Lys Pro Glu Tyr Arg Asn Gly Val Ser Gly 
145                 150                 155                 160 


Phe Asp Tyr Glu Arg Ile Arg Ala Glu Glu Ser Leu Glu Arg Glu Met 
                165                 170                 175     


Glu Lys Tyr Val Leu Phe Ala Val Asn Asn Phe Ala Arg Ala Val Thr 
            180                 185                 190         


Pro Glu Glu Glu Arg Glu Lys Ser Gly His Glu Asp Val Leu Leu Met 
        195                 200                 205             


Lys Thr Leu Ser Glu Ile Glu Glu Ser Gln Thr Lys Glu Glu Arg Gln 
    210                 215                 220                 


Lys Lys His Asp Asn Asn Val Lys Asn Ala Ile Thr Leu Tyr Ala Asp 
225                 230                 235                 240 


Ala Asp Arg Arg Ile Leu Gln Phe Phe Gly Gly Gln Ser Arg Phe Arg 
                245                 250                 255     


Glu Lys Glu Asp Ser Leu Ile Asn Leu Tyr Ser Gly Glu Asp Leu Tyr 
            260                 265                 270         


Lys Glu Ile Arg Lys Glu Leu Tyr Ala Ile Arg Asn Ile Thr Phe His 
        275                 280                 285             


Tyr Thr Thr Lys Ala Asp Lys Asp Gln Thr Gln Lys His Asp Leu Ala 
    290                 295                 300                 


Glu Tyr Leu Phe Glu Glu Glu Phe Ser Asp Ile Thr Glu Leu Phe Arg 
305                 310                 315                 320 


Glu Lys Tyr Tyr Ala Asn Asn Val Trp Lys Tyr Tyr Asp Val Glu Val 
                325                 330                 335     


Ile Asn Thr Ile Met Glu Asn Ile Tyr Cys Gly Arg Lys Tyr Arg Ala 
            340                 345                 350         


Ala Gln Val Pro Ala Phe Lys Asn Ile Ile Ser Arg Pro Glu Leu Pro 
        355                 360                 365             


Gln Val Met Asn Gly Phe Val Lys Gly Asn Ser Leu Arg Arg Leu Met 
    370                 375                 380                 


Asn Cys Pro Asp Arg Asp Val Ile Asn Lys Tyr Trp Ser Ala Leu Phe 
385                 390                 395                 400 


Phe Val Leu Lys Glu Leu Tyr Tyr Tyr Asp Phe Leu Gln Glu Gln Lys 
                405                 410                 415     


Lys Pro Glu Asp Asn Val Lys Glu Arg Phe Phe Arg Ala Ile Glu Lys 
            420                 425                 430         


Leu Ser Gly Gln Glu Asn Asp Asp Lys Lys Gln Lys Ala Trp Glu Ser 
        435                 440                 445             


Phe Gly Asn Arg Ile Asp Gln Ile Gly Arg Asp Arg Ser Phe Gly Ala 
    450                 455                 460                 


Ile Cys Gln Gly Leu Met Ile Glu Tyr Met Leu Gln Asn Ser Asp Ile 
465                 470                 475                 480 


Ser Met Val Gln Thr Glu Thr Asp Asn Gly Lys Ala Asn Asn Lys Lys 
                485                 490                 495     


Gln Ile Tyr Lys His Tyr Arg Thr Leu Leu Tyr Asn Cys Ile Arg Glu 
            500                 505                 510         


Ala Phe Ile Glu Tyr Leu Arg Glu Lys Trp Glu Glu Leu Arg Thr Pro 
        515                 520                 525             


Val Leu Thr Val Lys Glu Trp Ser Lys Glu Glu Phe Cys Arg Ala Asp 
    530                 535                 540                 


Gly Leu Lys His Leu Ser Leu Phe Asp His Leu Lys Lys Thr Phe Asn 
545                 550                 555                 560 


Asp Ala Glu Ser Gly Ser Ser Trp Tyr Met Ala Ala His Phe Ile Asn 
                565                 570                 575     


Gln Lys Tyr Leu Asn His Leu Leu Gly Ser Ile Arg Asn Tyr Leu Gln 
            580                 585                 590         


Phe Thr Glu Asp Ile Glu Asp Arg Ala Ile Ser Leu Gly Asp Cys Val 
        595                 600                 605             


Asp Asn Lys Arg Glu Glu Lys Asn Leu Arg Tyr Arg Asn Thr Leu Glu 
    610                 615                 620                 


Ile Leu Glu Phe Val Ala Gln Phe Cys Glu Arg Thr Thr Asn Val Met 
625                 630                 635                 640 


Glu Asp Tyr Phe Glu Ser Asn Gln Glu Tyr Ala Glu Tyr Leu Ser Gly 
                645                 650                 655     


Phe Val Asp Tyr Asn Thr Thr Lys Lys Glu Thr Asp Ile Glu Lys Ala 
            660                 665                 670         


Leu Tyr Ser Phe Cys Lys Gln Lys Phe Lys Val Asp Gly Lys Glu Tyr 
        675                 680                 685             


Met Ala Gly Ile Tyr Tyr Asp Gly Glu Asn Leu Ile Pro Asn Arg Asn 
    690                 695                 700                 


Ile Ile Arg Ala Asn Met Tyr Gly Asn Thr Ser Cys Leu Lys Pro Cys 
705                 710                 715                 720 


Met Asp Arg Ile Thr Leu Lys Glu Ile Arg Thr Met Tyr Ala Asp Gln 
                725                 730                 735     


Asn Lys Leu Asp Leu Val Leu Lys Glu Gly Val Cys His Thr Glu Glu 
            740                 745                 750         


Glu Gln Lys Ala Tyr Arg Glu Tyr Gln Asn Glu Lys Asn Arg Ile Glu 
        755                 760                 765             


Leu Phe Asp Val Cys Thr Tyr Thr Gln Ile Leu Asn Asp Met Gln Ala 
    770                 775                 780                 


Arg Leu Ile Gly Trp Ser Tyr Met Arg Glu Arg Asp Leu Met Tyr Tyr 
785                 790                 795                 800 


Gln Leu Gly Tyr Tyr Tyr Thr Lys Leu Phe Trp Thr Asp Ser Ile Ser 
                805                 810                 815     


Glu Glu Asp Ala Arg Arg Arg Leu Val Gly Asn Leu Val Asn Val Glu 
            820                 825                 830         


Asp Gly Ala Ile Leu Tyr Gln Ile Leu Ala Phe Asn Ser Tyr Asn Leu 
        835                 840                 845             


Pro Ile Ile Ala Asn Lys Asn Asn Thr Val Thr Leu Leu Lys Asp Glu 
    850                 855                 860                 


Gly Ser Ile Gly Gly Lys Ala Ile Thr Ala Phe Phe Lys Asn Tyr Glu 
865                 870                 875                 880 


Asn Ala Glu Met Ile Tyr Glu Glu Ala Leu Asp Leu Phe Glu Asn Met 
                885                 890                 895     


Asp Glu His Ala Ala Ile Ile Asn Thr Arg Asn Tyr Ile Glu His Phe 
            900                 905                 910         


Lys Tyr Phe Ile Lys Ser Asp Arg Ser Met Met Asp Leu Tyr Ser Glu 
        915                 920                 925             


Ile Tyr Asp Arg Phe Phe Arg His Asp His Asn Arg Lys Lys Asn Val 
    930                 935                 940                 


Pro Asp Ser Ala Val Lys Thr Phe Trp Gln Thr Ile Leu 
945                 950                 955         


<210>  1316
<211>  1095
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1316

Met Lys Val Ser Lys Val Asp Asn Ile Asn His Tyr Lys Thr Lys Glu 
1               5                   10                  15      


Lys Ser Ala Leu Ile Lys Glu Asn Asn Ile Lys Glu Asp Leu Thr Thr 
            20                  25                  30          


Tyr Thr Val Asn Lys Ile Asp Glu Arg Leu Leu Lys Ser Ile Ser His 
        35                  40                  45              


Lys Asn Ser Lys Thr Asp Ile Tyr Ala Tyr Lys Asp Ile Leu Asp Lys 
    50                  55                  60                  


Phe Asp Phe Lys Lys Glu Ile Thr Glu Ile Asn Asn Asn Leu Gln Gln 
65                  70                  75                  80  


Ile Leu Lys Gln Asp Tyr Val Glu Lys Ile Ile Gly Ser Glu Glu Gly 
                85                  90                  95      


Leu Asn Thr Ile Glu Lys Asn Leu Ser Asn Lys Asp Arg Thr Ile Ser 
            100                 105                 110         


Thr Tyr Glu Asp Ile Val Leu Arg Thr Thr Lys Asn Tyr Leu Leu Asn 
        115                 120                 125             


Asn Asn Ser Ile Asp Asn Asp Lys Phe Lys Glu Leu Ala Met Tyr Ala 
    130                 135                 140                 


Leu Lys Phe Leu Val Tyr Arg Lys Asn Ile Gln Lys Pro Arg Ile Glu 
145                 150                 155                 160 


Lys Ser Leu Lys Asn Asn Lys Ile Tyr Thr Glu Tyr Thr Lys Asn Lys 
                165                 170                 175     


Asn Phe Ile Leu Ser Phe Thr Lys Glu Glu Asn Asn Val Ile Gln Ile 
            180                 185                 190         


Asp Glu Asp Lys Ile Asp Lys Leu Leu Glu Lys Tyr Glu Phe Asn Thr 
        195                 200                 205             


Cys Ile Glu Glu Ile Val Lys Ile Asp Tyr Lys Phe Asn Ser Asn Ile 
    210                 215                 220                 


Asn Lys Asp Phe Ile Ile Lys Leu Lys Asn Glu Ile Asn Asn Lys Ile 
225                 230                 235                 240 


Tyr Thr Asn Lys Lys Gln Leu Leu Asn Asn Val Asp Asn Asn Leu Ile 
                245                 250                 255     


Glu Leu Asn Gly Phe Tyr Ser Glu Leu Lys Gln Tyr Phe Asn Asn Glu 
            260                 265                 270         


Leu Ser Lys Gln Asn Asn Thr Ile Gln Ile Asn Leu His Asn Ile Phe 
        275                 280                 285             


Asn Lys Asn Val Ile Lys Asn Ile Ile Lys Ser Arg Ile Lys Asn Lys 
    290                 295                 300                 


Ile Thr Gln His Tyr Ile Leu Lys Gly Lys Leu Lys Tyr Tyr Gly Ile 
305                 310                 315                 320 


Leu Glu Lys Asn Ala Asp Thr Tyr Glu Leu Ser Leu Ile Lys Ser Lys 
                325                 330                 335     


Glu Ser Val Lys Lys Gln Phe Leu Thr Ser Ile Val Met Ala Gly Ser 
            340                 345                 350         


Lys Leu Lys Leu Ile Tyr Asp Arg Asp Asn Lys Cys Asn Asn Lys Asp 
        355                 360                 365             


Ile Tyr Lys Ile Glu Asn Leu Asp Asn Asp Leu Glu Glu Asn Leu Thr 
    370                 375                 380                 


Lys Leu Ile Ile Gly Leu Tyr Asp Phe Asp Tyr Lys Asp Leu Cys Lys 
385                 390                 395                 400 


Glu Met Phe Lys Cys Leu Ile Leu Leu Arg Asn Asn Phe Val His Phe 
                405                 410                 415     


Lys Asn Phe Thr Leu Glu Glu Met Thr Lys Ala Ile Ser Asp Ser Asp 
            420                 425                 430         


Thr Asn Gly Ile Gln Phe Glu Glu Ile Phe Lys Leu Leu Asn Lys Asp 
        435                 440                 445             


Val Lys Lys Ala Lys Glu Asn Ile Lys Leu Asn Ile Gln Asn Met Asn 
    450                 455                 460                 


Ile Phe Glu Cys Asp Asp Asp Ile Ile Asn Phe Asn Leu Ile Glu Glu 
465                 470                 475                 480 


Ile Asn Leu Cys Pro Asn Leu Cys Ser Tyr Ser Tyr Pro Ser Phe Ser 
                485                 490                 495     


Asn Val Tyr Lys Lys Gly Leu Asp Met Asn Lys Phe Phe Lys Asn Lys 
            500                 505                 510         


Tyr Lys Ile Tyr Lys Glu Lys Gly Glu Trp Thr Asp Thr Lys Tyr Leu 
        515                 520                 525             


Gly Tyr Lys Asn Tyr Leu Lys Leu Val Tyr Lys Tyr Lys Phe Leu Asn 
    530                 535                 540                 


Ser Ile His Asn Ile Lys Leu Ser Glu Ser Ile Thr Gln Ile Leu Lys 
545                 550                 555                 560 


Gln Asn Lys Glu Ala Asn Asn Asn Thr Gln Gly Tyr Lys Tyr Asn Glu 
                565                 570                 575     


Ile Asp Lys Leu Trp Lys Ala Tyr Cys Lys Asn Asn Lys Asp Lys Asp 
            580                 585                 590         


Ala His Ile His Ser Phe Phe Lys Asp Ile Gln Arg Lys Glu Met Glu 
        595                 600                 605             


Lys Ala Ser Leu Asn Glu Gln Asn Glu Ala Glu Lys Asn Gln Tyr Thr 
    610                 615                 620                 


Asp Phe Ile Arg Asp Val Tyr Ala Asn Cys Phe Asn Arg Trp Ile Thr 
625                 630                 635                 640 


Ser Lys Cys Lys Asn Lys Asn Asn Ile Asp Lys Asn Asn Val Leu Glu 
                645                 650                 655     


Lys Ile Asn Ile Lys Gly Leu Glu Lys Phe Asn Ile Asp Tyr Thr Lys 
            660                 665                 670         


Asp Glu Glu Lys Ile Tyr Leu Ile Tyr Tyr Ser Leu Phe Lys Leu Leu 
        675                 680                 685             


Asp Asn Tyr Gln Ile Gly Gln Ile Gln Ala His Leu Lys Lys Tyr Tyr 
    690                 695                 700                 


Ala Ile Asn Asn Asn Asn Asn Asn Leu Ser Phe Phe Glu Asn Leu Asn 
705                 710                 715                 720 


Ser Tyr Ala Glu Leu Ala Lys Ile Ser Thr Pro Ile Phe Asn Leu Tyr 
                725                 730                 735     


Ile Glu Asn Asn Ile Asp Lys Gln Lys Lys Lys Gly Asn Ile Glu Asp 
            740                 745                 750         


Leu Asn Asn Tyr Ile Ile Asp Thr Met Lys Asn Phe Phe Lys Glu Asp 
        755                 760                 765             


Asp Ile Leu Glu Asp Glu Leu Tyr Leu Gln Glu Asp Lys Lys Thr Pro 
    770                 775                 780                 


Ile Tyr His Lys Gly Ile Thr Asp Leu Ile Leu Ser Gly Arg Gln Glu 
785                 790                 795                 800 


Leu Phe Lys Lys Gln Tyr Gln Asn Phe Ile Thr Lys Asp Asp Ile Lys 
                805                 810                 815     


Glu Tyr Lys Glu Leu Ser Lys Glu Ile Glu Lys Ile Gln Lys Glu Arg 
            820                 825                 830         


Glu Lys Lys His Arg Ser Ile Val Ile Asn Lys Tyr Ala Leu Glu Lys 
        835                 840                 845             


Cys Asp Lys Leu Val Lys Glu Tyr Glu Ala Leu Val Lys Lys Ile Gln 
    850                 855                 860                 


Lys Tyr Asp Glu Tyr Lys Asn Lys Val Thr Phe Val Asn Phe Ser Lys 
865                 870                 875                 880 


Leu Ala Lys Leu Gln Tyr Glu Ile Leu Ser Arg Tyr Ile Gly Tyr Ala 
                885                 890                 895     


Leu Asp Trp Glu Arg Asp Met Gln Phe Leu Leu Leu Gly Ile Asn Asn 
            900                 905                 910         


Asp Ser Val Asn Lys Asp Lys Ile Asn Lys Ile Asn Ser Ile Phe Asp 
        915                 920                 925             


Gly Tyr Val Cys Asn Asn Leu Thr Asp Lys Ile Ser Lys Asn Ile Gly 
    930                 935                 940                 


Glu Glu Phe Lys Glu Phe Leu Trp Arg Ile Tyr Ser Lys Glu Lys Asn 
945                 950                 955                 960 


Leu Ile Ser Lys Lys Asp Ile Lys Ser Ile Phe Glu Ile Arg Asn Asn 
                965                 970                 975     


Ile Ala His Met Asp Ile Leu Arg Asn Asn Asn Lys Ser Met Leu Ser 
            980                 985                 990         


Tyr Ile Leu Ser Ile Gln Asn Leu  Met Ser Tyr Asp Arg  Lys Lys Arg 
        995                 1000                 1005             


Asn Ala  Ile Thr Lys Ser Ile  Ile Glu Ile Phe Glu  Arg Asn Asn 
    1010                 1015                 1020             


Met Asp  Ile Ala Phe Asp Ile  Thr Asn Tyr Gly Ser  Lys Asn Leu 
    1025                 1030                 1035             


Lys Leu  Lys Tyr Leu Lys Ser  Lys Lys Ser Gln His  Leu Lys Gly 
    1040                 1045                 1050             


Lys Ile  Lys Ser Glu Lys Asn  Glu Lys Glu Lys Asn  Lys Asn Arg 
    1055                 1060                 1065             


Thr Lys  Thr Tyr Thr Thr Lys  Val Glu Phe Tyr Val  Gln Asn Lys 
    1070                 1075                 1080             


Thr Tyr  Met Asp Met Leu Asn  Lys Phe Ile Asp Arg  
    1085                 1090                 1095 


<210>  1317
<211>  904
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1317

Leu Lys Trp Arg Lys Asn Met Lys Leu Ser Lys Val Thr Tyr Arg Val 
1               5                   10                  15      


Lys Asp Lys Asn Ala Lys Tyr Lys Lys Glu Tyr Asn Val Arg Ala Ala 
            20                  25                  30          


Val Ala Asn Asn Ser Glu Asn Ala Gly Gly Val Leu Tyr His Val Pro 
        35                  40                  45              


Gly Val Asp Leu Ile Asp Leu Arg Glu Gln Met Leu Asp Arg Asp Arg 
    50                  55                  60                  


Ser Val Arg Leu Leu Tyr Asn Ile Phe Asn His Ile Gln Thr Gly Thr 
65                  70                  75                  80  


Lys Pro Lys Lys Trp Gly Asn Asp Glu Thr Leu Ser Val Asp Glu Asn 
                85                  90                  95      


Glu Arg Lys Ala Lys Glu Gln Asn Ile Lys Ile Met Asn Tyr Lys Trp 
            100                 105                 110         


Arg Glu Ala Cys Ser Glu Tyr Ile Glu Lys Ser Gln Ser Thr Ile Asn 
        115                 120                 125             


Ser Val Leu Phe Tyr Ser Tyr Glu Glu Ser Gly Tyr Lys Thr Lys Arg 
    130                 135                 140                 


Met Asn Asp Asn Glu Ala Ile Ile Val Lys Met Gln Tyr Glu Asn Arg 
145                 150                 155                 160 


Leu Ser His Phe Thr Gly Gly Lys Leu Glu Asp Phe Val Ala Tyr Thr 
                165                 170                 175     


Leu Arg Asn Ser Leu Val Val Ser Arg Tyr Asp Asn Gln Glu Phe Asp 
            180                 185                 190         


Ser Val Asn Ala Met Val Val Phe Ile Asn Asn Ile Gly Asn Gly Asn 
        195                 200                 205             


Ile Ser Asp Lys Asp Lys Lys Thr Ile Cys Lys Leu Ala Asp Leu Ile 
    210                 215                 220                 


Arg Asn Asp Phe Ser Lys Leu Asn Pro Asn Val Gln Ser Ser Gln Gly 
225                 230                 235                 240 


Ala Asn Met Val Arg Ser Val Arg Asn Gln Asn Met Val Val Gln Pro 
                245                 250                 255     


Gln Gly Asp Lys Val Ser Phe Pro Leu Val Ser Asp Glu Gly Lys Asn 
            260                 265                 270         


Thr Val Thr Asn Lys Asn Val Glu Lys Lys Gly Leu Asn Glu Phe Leu 
        275                 280                 285             


Leu Asn Tyr Ala Asn Leu Asp Asp Glu Glu Arg Met Glu Lys Leu Arg 
    290                 295                 300                 


Lys Leu Arg Arg Ile Ile Asp Val Tyr Phe Ser Ser Pro Ser His Tyr 
305                 310                 315                 320 


Gln Lys Asp Met Asp Ile Ser Leu Ser Asp Asn Ile Asp Lys Thr Lys 
                325                 330                 335     


Phe Asp Val Trp Lys Lys His Glu Thr Gly Lys Lys Asn Thr Glu Leu 
            340                 345                 350         


Phe Val Asp Ile Pro Asp Glu Leu Leu Thr Ala Glu Thr Glu Lys Ile 
        355                 360                 365             


Lys Leu Asp Ala Val Leu Glu Lys Lys Ala Arg Lys Arg Leu Thr Asp 
    370                 375                 380                 


Ser Ile Arg Lys Gln Asn Met Ile Cys Tyr Arg Tyr Thr Arg Ala Val 
385                 390                 395                 400 


Val Glu Lys Tyr Asn Ser Thr Glu Asn Leu Phe Phe Glu Asn Asp Ser 
                405                 410                 415     


Ile Asn Gln Tyr Trp Ile His His Ile Glu Asn Ala Val Glu Arg Ile 
            420                 425                 430         


Leu Lys Ser Cys Lys Ala Glu Thr Leu Phe Lys Leu Arg Arg Gly Tyr 
        435                 440                 445             


Leu Thr Glu Lys Val Trp Lys Asp Ala Ile Asn Leu Ile Ser Ile Lys 
    450                 455                 460                 


Tyr Ile Ala Leu Gly Lys Val Ile Tyr Asn Phe Thr Val Asp Asp Ile 
465                 470                 475                 480 


Trp Lys Asp Lys Lys Val Lys Asn Leu Gly Ser Ile Asp Glu Lys Ile 
                485                 490                 495     


Lys His Gly Ile Thr Ser Phe Asp Tyr Glu Met Ile Lys Ala Gln Glu 
            500                 505                 510         


Ala Leu Gln Arg Glu Leu Ala Val Asn Val Ala Phe Ala Ala Asn Asn 
        515                 520                 525             


Leu Ala Arg Ala Val Cys Asp Met Thr Asn Leu Lys Asp Lys Glu Ser 
    530                 535                 540                 


Asp Phe Leu Ile Trp Asn Lys Lys Asp Ile Ala Asn Lys Leu Lys Asn 
545                 550                 555                 560 


Lys Asp Asp Met Ala Ser Val Ser Val Val Leu Gln Phe Phe Gly Gly 
                565                 570                 575     


Lys Ser Ser Trp Asp Ile Asp Ala Phe Arg Glu Ala Tyr Lys Gly Asn 
            580                 585                 590         


Lys Tyr Asn Tyr Glu Val Cys Phe Ile Asp Asp Leu Arg Lys Ala Val 
        595                 600                 605             


Tyr Ala Ala Arg Asn Glu Ser Phe His Phe Lys Thr Ala Leu Val Asn 
    610                 615                 620                 


Asn Asp Ile Trp Asn Thr Glu Phe Phe Gly Lys Leu Phe Ile Lys Glu 
625                 630                 635                 640 


Thr Glu Ile Cys Leu Asp Ile Glu Lys Asp Arg Phe Tyr Ser Asn Asn 
                645                 650                 655     


Leu Pro Val Phe Tyr Ser Asp Asn Asp Leu Lys Lys Met Leu Asp His 
            660                 665                 670         


Leu Tyr Asn Asn Lys Val Ser Arg Ala Ala Gln Val Pro Ser Tyr Asn 
        675                 680                 685             


Ser Val Met Val Arg Lys Tyr Phe Pro Glu Asn Ile Thr Ser Thr Leu 
    690                 695                 700                 


Lys Tyr Gln Lys Pro Gly Tyr Asp Glu Asp Thr Leu Glu Lys Trp Tyr 
705                 710                 715                 720 


Ser Ala Cys Tyr Tyr Leu Leu Lys Glu Ile Tyr Tyr Asn Ser Phe Leu 
                725                 730                 735     


Gln Ser Asp Glu Ala Leu Ala Leu Phe Glu Glu Ser Val Asn Asn Leu 
            740                 745                 750         


Lys Gly Asp Asn Lys Asp Gln Glu Leu Ala Val Lys Asn Phe Arg Asn 
        755                 760                 765             


Asn Tyr Lys Asn Ile Lys Ser Ser Cys Thr Ser Phe Ser Gln Val Cys 
    770                 775                 780                 


Gln Met Tyr Met Thr Glu Tyr Asn Gln Gln Asn Asn Gln Phe Lys Lys 
785                 790                 795                 800 


Val Arg Ser Ser Lys Asp Ser Ile Val Asp Lys Pro Ile Tyr Gln His 
                805                 810                 815     


Tyr Lys Leu Leu Leu Lys Lys Val Ile Ala Asn Ala Phe Ala Ser Tyr 
            820                 825                 830         


Leu Gln His Asn Glu Glu Leu Phe Gly Phe Ile Gly Lys Pro Leu Lys 
        835                 840                 845             


Val Asn Cys Leu Lys Glu Ile Asp Lys Glu Gln Phe Leu Pro Glu Trp 
    850                 855                 860                 


Thr Ser Lys Lys Tyr Val Ser Leu Cys Glu Glu Val Arg Lys Ser Pro 
865                 870                 875                 880 


Glu Leu Gln Lys Trp Tyr Ile Val Gly Lys Phe Leu Asn Ser Arg Ser 
                885                 890                 895     


Leu Asn Leu Met Ala Gly Ser Met 
            900                 


<210>  1318
<211>  927
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1318

Met Arg Ile Thr Lys Pro Tyr Gly Arg Thr His Val Glu Arg Asp Pro 
1               5                   10                  15      


Ser Gly Lys Thr Arg Arg Val Leu Arg Pro Arg Ser Ser Ser Asn Thr 
            20                  25                  30          


Asn Tyr Asp Ile Glu Gln Phe Ala Leu Thr His Asp Glu Leu Val Ile 
        35                  40                  45              


Ala Gln Trp Val Ser Thr Ile Asp Lys Ile Ser Thr Lys Pro Arg Gly 
    50                  55                  60                  


Lys Asn Gly Pro Thr Asp Glu Gln Arg Trp Phe Arg Lys Arg Leu Gly 
65                  70                  75                  80  


Asp Ala Ala Trp Ser Leu Leu Ile Gln Glu Lys Leu Leu Pro Gly Ala 
                85                  90                  95      


Glu Glu Pro Thr Arg Arg Glu Asp Leu His Lys Leu Trp Gly Ser Lys 
            100                 105                 110         


Ile Glu Pro Tyr Gly Ser Ala Pro Tyr Lys Pro Ser Lys Phe Lys Pro 
        115                 120                 125             


Ala Pro Pro Thr Lys Gly Arg Trp Phe Val Arg Phe Ala Gly Ala Cys 
    130                 135                 140                 


Ser Ile Ala Asp Ala Ser Ile Asp Asp Ile Val Arg Gln Val Lys Val 
145                 150                 155                 160 


His Leu Tyr Gln Ser Gly Phe Arg Leu Gly Ser Ser Val Thr Lys Lys 
                165                 170                 175     


Ser Gly Gly His Ile Ser Leu Arg Ala Lys Ser Ile Thr Ala Asn Val 
            180                 185                 190         


Ala Gly Ser Asp Ser Ser Ser Thr Arg Gly Leu Ile Ser Trp Asn Ala 
        195                 200                 205             


Ala Asp Cys Ala Arg Tyr Ala Leu Val Gly Asn Val Ala Gln Glu Ile 
    210                 215                 220                 


Arg Ala Ala Ala Glu Lys Arg Glu Arg Arg Glu Asp Gly Ala Thr Asn 
225                 230                 235                 240 


Ala Met Leu Thr His Asp Val Ala Gly Gln Val Leu Phe Asp His Tyr 
                245                 250                 255     


Ala Arg Leu Phe Pro Ala Ala Asn Gly Ser Ala Leu Thr Ile Ser Gln 
            260                 265                 270         


Ala Arg Glu Thr Glu Pro Gly Leu Phe Tyr Leu His Met Ala Val Lys 
        275                 280                 285             


Asp Cys Tyr Ala Arg Ile Leu Lys Arg Pro Arg Lys Glu Lys Asn Gln 
    290                 295                 300                 


Asn Ser Arg Arg Thr Lys Ser Gly Gly Pro Ala Gly Pro Arg His Leu 
305                 310                 315                 320 


Ser Asp Lys Asn Arg Asn Ala His Asn Thr Arg Ser Ala Leu Phe Met 
                325                 330                 335     


Arg Leu Pro Val Asn Met Glu Ser Leu Phe Ala Leu Val Glu Asn Lys 
            340                 345                 350         


Leu Ala Asn Arg Asp Leu Asn Ala Leu Val Arg Leu Gly Lys Val Ile 
        355                 360                 365             


His Tyr Asp Ala Ser Trp Gln Gly Arg Gln Gln Ser Pro Thr Pro Leu 
    370                 375                 380                 


Gly Ala Val Asp Asp Ala Asp Lys Thr Asn Ala Ile Ser Gln Asn Trp 
385                 390                 395                 400 


Ser Ala Asp Ile Ser Leu Ser His Tyr Trp Thr Ser Gln Gly Gln Asn 
                405                 410                 415     


Glu Ile Lys Phe Asn Glu Ser Phe Val Arg Val Trp Arg His Thr Ile 
            420                 425                 430         


Ala Ile Ala Ser Arg Thr Leu Val Asp Trp Ala Asp Pro Lys Arg Arg 
        435                 440                 445             


Ile Glu Ala Pro Asn Val Asp Ile Leu Leu Glu Gly Ala Ile Lys Glu 
    450                 455                 460                 


Ala Thr Gly Ala Lys Phe Asp Ala Asp Gly Tyr Ala His Lys Thr Pro 
465                 470                 475                 480 


Leu Leu Phe Gly Asn Arg Ser Ile Leu Phe Glu Asn Gly Asp Asp Gln 
                485                 490                 495     


Phe Arg Arg Glu Ile Leu Arg Phe Ala Leu Glu Gly Leu Ala His Leu 
            500                 505                 510         


Arg His Asn Ser Phe His Phe Lys Gly Leu Gly Ser Phe Ile Asp Ala 
        515                 520                 525             


Leu Val Gln Leu Thr Pro Ser Thr Asn Gln Arg Cys Leu Asp Ala Val 
    530                 535                 540                 


Arg Asp Leu Trp Thr Asp Asp Ser Ala Ser Arg Val Arg Gln Gln Ile 
545                 550                 555                 560 


Glu Thr Met Ser Ala Ala Arg Phe Asp Tyr Phe Phe Ala Pro Asp Gln 
                565                 570                 575     


Ala Gln Lys Leu Ala Asp Ala Met Ser Ser Val Asp Val Gly Thr Ile 
            580                 585                 590         


Pro Leu Pro Arg Phe Asn Arg Leu Leu Glu Arg Val Gln Asn Ala Trp 
        595                 600                 605             


Ser Glu Gly Glu Ser Arg Leu Gly Phe Pro Leu Pro Ala Asn Arg Val 
    610                 615                 620                 


Ala Leu Glu Asn Pro Ala Leu Met Cys Gln Tyr Thr Ala Leu Lys Leu 
625                 630                 635                 640 


Val Tyr Glu His Ala Phe Arg Ala Trp Leu Gln Arg Cys Ser Pro Ser 
                645                 650                 655     


Thr Leu Asn Asn Leu Ile Glu Arg Ala Ile Ala Arg Thr Thr Ser Ala 
            660                 665                 670         


Ala Arg Glu Leu Asn Ala Ala Glu Gly Gly Ala Trp Arg Glu Leu Ile 
        675                 680                 685             


Val Ala Arg Ala Ala His Ile Gly Arg Val Asp Asp Asp Gly Gly Ile 
    690                 695                 700                 


Glu Ala Phe Phe Phe Asn Leu Ser Ala Glu Thr Ala Ser Glu Met Arg 
705                 710                 715                 720 


Val Gln Arg Gly Tyr Glu Gly Asp Ser Asp Lys Ala Arg Glu Gln Ser 
                725                 730                 735     


Ala Tyr Ile Glu Lys Phe Lys Cys Asp Val Ile Ala Leu Ala Phe Asp 
            740                 745                 750         


Leu Phe Leu Arg Thr Glu Lys Leu Asp Phe Val Leu Thr Leu Ala Ile 
        755                 760                 765             


Asp Ala Ala Ile Pro Thr Val Pro Leu Cys Asp Leu Ser Arg Phe Ala 
    770                 775                 780                 


Ser Thr Lys Gly Val Ala Glu Pro Gln Pro Trp Gln Pro Ala Leu Tyr 
785                 790                 795                 800 


Phe Leu Met His Leu Val Pro Val Asp Asp Val Gly Arg Leu Leu His 
                805                 810                 815     


Gln Ile Arg Lys Ser Asp Val Leu Ala Glu Gly Asp Leu Asp Thr Arg 
            820                 825                 830         


Arg Val Pro Ser Arg Pro Gly Gly Pro Arg Thr Ser Leu Gln Lys His 
        835                 840                 845             


Ile Gln His Leu Leu Glu Val Phe Glu Leu Tyr Leu Asp Met His Asp 
    850                 855                 860                 


Ala Lys His Ser Gly Gly Phe Ser Leu Val Gly Thr Gln Pro Leu Arg 
865                 870                 875                 880 


Gly Leu Phe Glu Gln Pro Gly Leu Phe Asp Lys Val Phe Pro Glu Glu 
                885                 890                 895     


Thr Ser Gly Gln Gly Asp Asp Val Arg Ile Pro Arg Arg Gly Leu Arg 
            900                 905                 910         


Glu Val Met Arg Phe Gly His Leu Thr Ala Leu Arg Asn Ile Phe 
        915                 920                 925         


<210>  1319
<211>  986
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1319

Met Lys Val Thr Lys Ala Glu Lys Leu Arg Val Ala Val Ser Arg Lys 
1               5                   10                  15      


Leu Asn Asn Glu Asp Lys Arg Ala Val Leu Tyr Lys Thr Pro Asn Pro 
            20                  25                  30          


Gly Gln Thr Cys Gly Thr Val Lys Lys Gln Leu Ala Asn Arg Val Glu 
        35                  40                  45              


Arg Ala Asn Lys Leu Tyr Gly Val Phe Phe Arg Ser Asp Val Pro Glu 
    50                  55                  60                  


Thr Leu Gln Tyr His Phe Glu Glu Leu Val Thr Tyr Ala Ala Gln Ser 
65                  70                  75                  80  


Thr Ser Pro Asn Glu Phe Arg Gln Lys Ala Ser Gln Tyr Arg Glu Cys 
                85                  90                  95      


Glu Lys Lys Asp Lys Phe Gly Lys Met Arg Lys Tyr Pro Ile Phe Arg 
            100                 105                 110         


Cys Ser Tyr Ala Pro Ser Gly Lys Asn Met Lys Lys Val Met Glu Leu 
        115                 120                 125             


Tyr Val Arg Glu Arg Met Lys Asp Glu Trp Gln Ser Gln Ala Tyr Arg 
    130                 135                 140                 


Thr Ala Ala Ile Glu Ile Leu Leu Cys Ile Cys Asn Lys Asp Phe Ser 
145                 150                 155                 160 


Lys Gln Leu Ser Arg Val Asp Ala Arg Ile Phe Ala Asp Phe Tyr Asn 
                165                 170                 175     


Ala Ser Lys Ala Cys Pro Gln Pro Tyr Ile Gly Lys Ser Thr Gly Val 
            180                 185                 190         


Leu Glu Ala Ala Phe Thr Ser Val Met Lys Gln Met Ser Leu His Ala 
        195                 200                 205             


Lys Ala Asn Ala Ser Asn Lys Ile Trp Trp Leu Gln Asn Gln Leu Arg 
    210                 215                 220                 


Thr Ile Glu Leu Asn Lys Lys Ile Val Lys Ile Ser Asp Phe Lys Tyr 
225                 230                 235                 240 


Glu Tyr Ala Thr Glu Asp Arg Met Arg Ala Ile Leu Val Arg Met Arg 
                245                 250                 255     


Lys Ser Leu Lys Arg Gly Thr Asn Gly Asp Ile Ala Val Ala Leu Leu 
            260                 265                 270         


Gln Gly Ile Ala Gln Met Asn Gly Lys Thr Leu Ser Gly Val Leu Glu 
        275                 280                 285             


Glu Leu Ser Ala Asn Ser Glu Thr Lys Glu Gln Leu Ile Lys Phe Leu 
    290                 295                 300                 


Lys Ala Val His Glu Asp Tyr His Lys Thr Pro Ile Leu Lys Ala Ile 
305                 310                 315                 320 


Arg Asn Gln Asp Val Lys Val Gln Val His Glu Val Asp Pro Val Ser 
                325                 330                 335     


Pro Glu Gly Arg Ala Leu Asp Leu Ala Ser Ile Asn Val Ser Lys Gly 
            340                 345                 350         


Asn Glu Arg Lys Lys Tyr Lys Val Ala Leu Thr Gln Thr Leu Gly Asn 
        355                 360                 365             


Tyr Ala Lys Ser Pro Lys Asp Ala Thr Gln Thr Leu Lys Ala Ile Lys 
    370                 375                 380                 


Gly Val Leu Leu Asp Tyr Phe Met Trp Leu Asp Ser Asp Val Lys Ala 
385                 390                 395                 400 


Glu Phe Leu Glu Asp Asn Asn Leu Trp Lys Ile Pro Asn Arg Thr Glu 
                405                 410                 415     


Glu Tyr Phe Asp Asn Asn Phe Val Pro Ile Asp Asp Lys Lys Asp Asp 
            420                 425                 430         


Lys Ile Glu Ala Ile Glu Asp Phe Ala Ser Ile Trp Arg Gln Glu Arg 
        435                 440                 445             


Val Lys Asn Ser Arg Ile Lys Ala Arg Met Asn Tyr Val Asn Cys Gly 
    450                 455                 460                 


Lys Tyr Gln Gln Leu Ile Lys Gln Glu Thr Asp Asp Phe Arg Ile Cys 
465                 470                 475                 480 


Trp Ile Ser Tyr Ala Lys Asp Phe Val Glu Lys Asn Tyr Val Ser Lys 
                485                 490                 495     


Asn Arg Gln Phe Thr Gln Gly Asp Cys Phe Ser Thr Lys Met Leu Leu 
            500                 505                 510         


Glu Cys Trp Lys Glu Ile Ile Arg Phe Ile Cys Gly Lys Tyr Ile Asp 
        515                 520                 525             


Ile Gly Lys Ala Val Tyr His Phe Ala Met Pro Glu Thr Met Asn Ala 
    530                 535                 540                 


Arg Asp Ser Leu Ala Tyr Gly Val Leu Gly Glu Lys Tyr Lys Glu Gly 
545                 550                 555                 560 


Ile Ser Ser Phe Asp Tyr Glu Ala Ile Lys Ala Glu Glu Thr Leu Gln 
                565                 570                 575     


Arg Asp Ile Ala Lys Ala Ala Val Ala Ala Ile His Ala Phe Ser Gly 
            580                 585                 590         


Ser Val Ile Asp Asp Lys Lys Pro Val Glu Asp Ile Leu Phe Ile Lys 
        595                 600                 605             


Asp Glu Glu Leu Gln Glu His Ala Lys Ala Asp Asp Val Ile Val Lys 
    610                 615                 620                 


Gln Ile Leu Arg Phe Tyr Gly Gly Phe Ser Ser Val Glu Gly Arg Glu 
625                 630                 635                 640 


Lys Leu Glu Gly Met Ala Leu Ala Lys Glu Val Leu Ser Gln Leu Lys 
                645                 650                 655     


Ala Ile Arg Asn Glu Asn Phe His Phe Thr Gln Gly Lys Arg Lys Asn 
            660                 665                 670         


Val Glu Glu Asn Ile Pro Leu Thr Lys Ala Leu Trp Glu Asn Glu Glu 
        675                 680                 685             


Lys Val Tyr Arg Gln Thr Val Lys Glu Thr Tyr Tyr Ser Asn Asn Val 
    690                 695                 700                 


Ser Met Phe Tyr Ser Gln Glu Val Ile Gln Lys Leu Val Ala Glu Leu 
705                 710                 715                 720 


Tyr Gln Asn Asn Asn Val Ala Glu Ala Gln Ile Pro Ala Phe Arg Thr 
                725                 730                 735     


Ile Trp Lys Arg Lys Asp Leu Pro Glu Tyr Ile Gly Ser Leu Asn Ile 
            740                 745                 750         


Ser Trp Asp Lys Thr Glu Pro Lys Gln Val Ile Tyr Glu Gly Ala Leu 
        755                 760                 765             


Tyr Phe Leu Leu Lys Glu Ile Tyr Tyr Arg Asp Phe Ile Lys Ser Gly 
    770                 775                 780                 


Glu Ala Lys Lys Leu Phe Phe Asp Ala Val Met Asp Asn Ala Thr Glu 
785                 790                 795                 800 


Met Glu Lys Ser Ser Asn Ala Asp Ser Arg Asn Gln Glu Lys Lys Ala 
                805                 810                 815     


Leu Ala Asn Ala Gly Lys Asn Phe Arg Asp Tyr Val Asn Gly Leu Asn 
            820                 825                 830         


Ala Ser Thr Leu Gly Glu Val Cys Gln Phe Ile Gln Asn Glu Tyr Asn 
        835                 840                 845             


Gln Gln Asn Arg Gly Lys Gln Glu Gln Glu Ile Tyr Lys His Phe Lys 
    850                 855                 860                 


Met Leu Leu Pro Ile Cys Met Arg Lys Ala Phe Gln Arg Tyr Ile Asp 
865                 870                 875                 880 


Glu Lys His Ser Phe Ile Lys Lys Pro Gly Glu Leu Pro Gln Thr Thr 
                885                 890                 895     


Glu Asp Tyr Leu Glu Asn Val Lys Val Ala Cys Pro Glu Lys Lys Ile 
            900                 905                 910         


Lys Leu Gly Arg Trp Phe Thr Phe Ala His Phe Ile His Pro Arg Glu 
        915                 920                 925             


Leu Asn Phe Leu Ile Gly Asp Phe Lys Asn Tyr Ile Gln Tyr Arg Glu 
    930                 935                 940                 


Asp Val Leu Arg Arg Ser Glu His Ala Gly Gln Phe Ser Asp Thr Thr 
945                 950                 955                 960 


Glu Arg Asp Gly Glu Lys Ala Val Val Asp His Ala Val Gln Lys Ala 
                965                 970                 975     


Lys Asp Ile Leu Gly Val Leu Glu Phe Val 
            980                 985     


<210>  1320
<211>  1018
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1320

Met Gly Asn Leu Phe Gly His Lys Arg Trp Tyr Glu Val Ser Asp Arg 
1               5                   10                  15      


Gly Asp Asn Lys Ile Lys Arg Lys Val Lys Val Lys Arg Asn Tyr Asp 
            20                  25                  30          


Gly Asn Lys Tyr Ile Leu Asn Ile Asn Glu Asn Asn Asn Lys Glu Lys 
        35                  40                  45              


Ile Asp Asn Asn Lys Phe Ile Arg Glu Phe Val Asn Tyr Lys Lys Asn 
    50                  55                  60                  


Asp Asn Val Leu Ile Glu Phe Lys Arg Lys Phe His Ala Gly Asn Ile 
65                  70                  75                  80  


Leu Phe Lys Leu Lys Gly Asn Lys Arg Ser Ile Glu Asp Ser Asn Asp 
                85                  90                  95      


Phe Leu Lys Thr Glu Glu Val Val Leu Asp Lys Glu Ile Tyr Gly Gln 
            100                 105                 110         


Ser Glu Lys Leu Arg Asn Glu Lys Gly Ile Thr Lys Gln Gly Ile Leu 
        115                 120                 125             


Lys Glu Ile Ile Asp Lys Gly Ile Asn Glu Ser Asn Asp Ser Ile Leu 
    130                 135                 140                 


Ile Lys Thr Lys Phe Gly Lys Glu Ile Lys Ile Asn Phe Thr Asp Glu 
145                 150                 155                 160 


Ser Lys Lys Asn Lys Asn Glu Tyr Gln Ile Thr Leu Lys Val Ile Pro 
                165                 170                 175     


Glu Asn Glu Leu Lys Ile Lys Arg Glu Val Tyr Asp Val Phe Lys Met 
            180                 185                 190         


Ile Asn Met Asp Leu Tyr Gln Ile Ile Lys Glu Ile Ile Glu Asn Lys 
        195                 200                 205             


Val Glu Lys Leu Phe Glu Asn Arg Tyr Tyr Glu Glu Tyr Leu Arg Glu 
    210                 215                 220                 


Lys Leu Leu Glu Asp Asn Gln Ile Asn Val Ile Leu Thr Asn Phe Met 
225                 230                 235                 240 


Lys Ile Arg Glu Lys Thr Lys Ser Asn Ser Glu Ile Met Gly Phe Val 
                245                 250                 255     


Lys Phe Tyr Leu Asn Val Gly Gly Asp Lys Lys Lys Ser Glu Asn Lys 
            260                 265                 270         


Lys Met Phe Val Glu Lys Ile Leu Asn Thr Asn Val Asp Leu Thr Glu 
        275                 280                 285             


Glu Asp Ile Val Asp Phe Ile Val Lys Glu Leu Lys Phe Trp Asn Ile 
    290                 295                 300                 


Thr Lys Arg Ile Glu Lys Val Lys Glu Phe Asn Asn Lys Ser Leu Glu 
305                 310                 315                 320 


Asn Arg Arg Asn Arg Thr Tyr Ile Lys Ser Tyr Val Leu Leu Asp Lys 
                325                 330                 335     


His Glu Lys Phe Lys Arg Asp Arg Glu Asn Lys Lys Asp Lys Ile Val 
            340                 345                 350         


Lys Leu Phe Val Lys Asp Ile His Asn Asp Lys Met Glu Glu Lys Ile 
        355                 360                 365             


Asn His Ile Leu Ser Glu Phe Lys Ile Lys Glu Leu Ile Glu Lys Leu 
    370                 375                 380                 


Lys Glu Asn Thr Glu Asn Lys Asn Phe Asp Thr Glu Ile Phe Gly Ile 
385                 390                 395                 400 


Phe Lys Lys His Tyr Lys Val Asn Phe Asp Ser Lys Lys Phe Ser Asn 
                405                 410                 415     


Lys Ser Asp Glu Glu Lys Glu Leu Tyr Lys Ile Ile Tyr Arg Tyr Leu 
            420                 425                 430         


Lys Gly Arg Ile Glu Lys Ile Leu Ile Asn Gly Glu Lys Val Arg Leu 
        435                 440                 445             


Lys Lys Met Glu Lys Ile Glu Ile Glu Lys Ile Leu Asn Glu Ser Ile 
    450                 455                 460                 


Leu Ser Glu Lys Ile Leu Lys Arg Val Lys Gln Tyr Thr Leu Glu His 
465                 470                 475                 480 


Ile Met Tyr Leu Gly Lys Leu Val His Asn Lys Ile Asn Met Ala Thr 
                485                 490                 495     


Val Asn Thr Asn Asp Phe Phe Arg Leu His Ala Lys Glu Glu Leu Asp 
            500                 505                 510         


Leu Glu Leu Ile Thr Phe Phe Ala Ser Thr Asn Val Glu Leu Asn Lys 
        515                 520                 525             


Ile Phe Ser Arg Lys Asp Glu Tyr Glu Glu Asn Ile Asp Phe Phe Gly 
    530                 535                 540                 


Glu Gly Ala Phe Ser Lys Glu Lys Arg Lys Lys Ile Thr Leu Asn Lys 
545                 550                 555                 560 


Lys Ser Leu Asn Ser Lys Ile Lys Met Ile Arg Glu Leu Glu Phe Ile 
                565                 570                 575     


Asp Asn Lys Asn Glu Ile Ile Gln Glu Asn Phe Phe Asn Lys Phe Ile 
            580                 585                 590         


Lys Ile Gly Ala Asn Glu Arg Asn Arg Ile Leu His Ala Ser Asn Lys 
        595                 600                 605             


Arg Arg Val Pro Lys Gly Thr Gln Asp Asp Tyr Asn Lys Val Ile Asn 
    610                 615                 620                 


Ile Ile Gln Asn Leu Lys Ile Ser Asp Glu Glu Val Ser Lys Ala Leu 
625                 630                 635                 640 


Asn Leu Asp Val Val Phe Lys Asp Lys Lys Asn Ile Ile Thr Lys Ile 
                645                 650                 655     


Asn Asp Ile Gln Ile Ser Glu Glu Asn Asn Ser Ile Ile Lys Tyr Leu 
            660                 665                 670         


Pro Ser Phe Ser Lys Val Leu Pro Glu Ile Leu Asn Leu Tyr Lys Asn 
        675                 680                 685             


Lys Asn Lys Asn Asn Pro Phe Asp Thr Thr Glu Thr Glu Arg Ile Met 
    690                 695                 700                 


Leu Asn Ala Leu Ile Tyr Val Asn Lys Glu Leu Tyr Lys Lys Leu Ile 
705                 710                 715                 720 


Leu Glu Lys Asn Leu Glu Glu Asn Glu Ser Lys Asn Lys Phe Leu Lys 
                725                 730                 735     


Glu Leu Lys Lys Asn Leu Gly Gly Thr Asp Glu Thr Asp Glu Asn Ile 
            740                 745                 750         


Ile Glu Asn Tyr Tyr Lys Asn Thr Gln Ile Ser Ala Ser Lys Gly Asn 
        755                 760                 765             


Asn Lys Ala Ile Lys Lys Tyr Gln Lys Lys Val Ile Glu Cys Tyr Ile 
    770                 775                 780                 


Lys Tyr Leu Glu Glu Asn Tyr Arg Glu Leu Phe Asp Phe Ser Asp Phe 
785                 790                 795                 800 


Lys Met Asn Ile Glu Glu Ile Lys Lys Lys Ile Lys Asn Ile Asn Asp 
                805                 810                 815     


Asn Lys Thr Tyr Arg Gly Glu Ile Val Ile Lys Phe Asn Asp Arg Asn 
            820                 825                 830         


Ile Glu Ile Lys Asn Asp Phe Glu Tyr Val Ile Ser Ile Phe Ala Leu 
        835                 840                 845             


Leu Asn Ser Asn Ala Val Ile Asn Lys Ile Arg Asn Arg Phe Phe Ala 
    850                 855                 860                 


Thr Ser Val Trp Leu Asn Thr Ser Glu Tyr Gln Asn Ile Ile Asp Val 
865                 870                 875                 880 


Leu Asp Glu Ile Met Gln Leu Asn Thr Leu Arg Asn Glu Cys Ile Thr 
                885                 890                 895     


Glu Asn Trp Asn Leu Asn Leu Glu Glu Phe Ile Gln Lys Met Lys Asp 
            900                 905                 910         


Ile Glu Lys Glu Phe Glu Asp Phe Lys Ile Gln Thr Lys Lys Tyr Ile 
        915                 920                 925             


Phe Asn Thr Asn Tyr Glu Gly Ile Lys Ser Asn Val Leu Asn Lys Phe 
    930                 935                 940                 


Ile Gly Phe Ser Asp Val Gln Lys Ile Leu Glu Glu Lys Leu Asn Lys 
945                 950                 955                 960 


Leu Ile Glu Phe Glu Asn Asp Asn Glu Ile Lys Lys Lys Ile Asn Ser 
                965                 970                 975     


Asn Ser Leu Asp Ile Asp Glu Arg Lys Asn Leu Met Pro Asn Ile Asp 
            980                 985                 990         


Gln Lys Lys Gly Gly Ile Asp Leu  Ile Lys Glu Ile Asp  Glu Leu Ile 
        995                 1000                 1005             


Val Ile  Glu Lys Asn Asn Ile  Glu Lys Asn 
    1010                 1015             


<210>  1321
<211>  1285
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1321

Met Lys Leu Thr Arg Arg Arg Ile Ser Gly Asn Ser Val Asp Gln Lys 
1               5                   10                  15      


Ile Thr Ala Ala Phe Tyr Arg Asp Met Ser Gln Gly Leu Leu Tyr Tyr 
            20                  25                  30          


Asp Ser Glu Asp Asn Asp Cys Thr Asp Lys Val Ile Glu Ser Met Asp 
        35                  40                  45              


Phe Glu Arg Ser Trp Arg Gly Arg Ile Leu Lys Asn Gly Glu Asp Asp 
    50                  55                  60                  


Lys Asn Pro Phe Tyr Met Phe Val Lys Gly Leu Val Gly Ser Asn Asp 
65                  70                  75                  80  


Lys Ile Val Cys Glu Pro Ile Asp Val Asp Ser Asp Pro Asp Asn Leu 
                85                  90                  95      


Asp Ile Leu Ile Asn Lys Asn Leu Thr Gly Phe Gly Arg Asn Leu Lys 
            100                 105                 110         


Ala Pro Asp Ser Asn Asp Thr Leu Glu Asn Leu Ile Arg Lys Ile Gln 
        115                 120                 125             


Ala Gly Ile Pro Glu Glu Glu Val Leu Pro Glu Leu Lys Lys Ile Lys 
    130                 135                 140                 


Glu Met Ile Gln Lys Asp Ile Val Asn Arg Lys Glu Gln Leu Leu Lys 
145                 150                 155                 160 


Ser Ile Lys Asn Asn Arg Ile Pro Phe Ser Leu Glu Gly Ser Lys Leu 
                165                 170                 175     


Val Pro Ser Thr Lys Lys Met Lys Trp Leu Phe Lys Leu Ile Asp Val 
            180                 185                 190         


Pro Asn Lys Thr Phe Asn Glu Lys Met Leu Glu Lys Tyr Trp Glu Ile 
        195                 200                 205             


Tyr Asp Tyr Asp Lys Leu Lys Ala Asn Ile Thr Asn Arg Leu Asp Lys 
    210                 215                 220                 


Thr Asp Lys Lys Ala Arg Ser Ile Ser Arg Ala Val Ser Glu Glu Leu 
225                 230                 235                 240 


Arg Glu Tyr His Lys Asn Leu Arg Thr Asn Tyr Asn Arg Phe Val Ser 
                245                 250                 255     


Gly Asp Arg Pro Ala Ala Gly Leu Asp Asn Gly Gly Ser Ala Lys Tyr 
            260                 265                 270         


Asn Pro Asp Lys Glu Glu Phe Leu Leu Phe Leu Lys Glu Val Glu Gln 
        275                 280                 285             


Tyr Phe Lys Lys Tyr Phe Pro Val Lys Ser Lys His Ser Asn Lys Ser 
    290                 295                 300                 


Lys Asp Lys Ser Leu Val Asp Lys Tyr Lys Asn Tyr Cys Ser Tyr Lys 
305                 310                 315                 320 


Val Val Lys Lys Glu Val Asn Arg Ser Ile Ile Asn Gln Leu Val Ala 
                325                 330                 335     


Gly Leu Ile Gln Gln Gly Lys Leu Leu Tyr Tyr Phe Tyr Tyr Asn Asp 
            340                 345                 350         


Thr Trp Gln Glu Asp Phe Leu Asn Ser Tyr Gly Leu Ser Tyr Ile Gln 
        355                 360                 365             


Val Glu Glu Ala Phe Lys Lys Ser Val Met Thr Ser Leu Ser Trp Gly 
    370                 375                 380                 


Ile Asn Arg Leu Thr Ser Phe Phe Ile Asp Asp Ser Asn Thr Val Lys 
385                 390                 395                 400 


Phe Asp Asp Ile Thr Thr Lys Lys Ala Lys Glu Ala Ile Glu Ser Asn 
                405                 410                 415     


Tyr Phe Asn Lys Leu Arg Thr Cys Ser Arg Met Gln Asp His Phe Lys 
            420                 425                 430         


Glu Lys Leu Ala Phe Phe Tyr Pro Val Tyr Val Lys Asp Lys Lys Asp 
        435                 440                 445             


Arg Pro Asp Asp Asp Ile Glu Asn Leu Ile Val Leu Val Lys Asn Ala 
    450                 455                 460                 


Ile Glu Ser Val Ser Tyr Leu Arg Asn Arg Thr Phe His Phe Lys Glu 
465                 470                 475                 480 


Ser Ser Leu Leu Glu Leu Leu Lys Glu Leu Asp Asp Lys Asn Ser Gly 
                485                 490                 495     


Gln Asn Lys Ile Asp Tyr Ser Val Ala Ala Glu Phe Ile Lys Arg Asp 
            500                 505                 510         


Ile Glu Asn Leu Tyr Asp Val Phe Arg Glu Gln Ile Arg Ser Leu Gly 
        515                 520                 525             


Ile Ala Glu Tyr Tyr Lys Ala Asp Met Ile Ser Asp Cys Phe Lys Thr 
    530                 535                 540                 


Cys Gly Leu Glu Phe Ala Leu Tyr Ser Pro Lys Asn Ser Leu Met Pro 
545                 550                 555                 560 


Ala Phe Lys Asn Val Tyr Lys Arg Gly Ala Asn Leu Asn Lys Ala Tyr 
                565                 570                 575     


Ile Arg Asp Lys Gly Pro Lys Glu Thr Gly Asp Gln Gly Gln Asn Ser 
            580                 585                 590         


Tyr Lys Ala Leu Glu Glu Tyr Arg Glu Leu Thr Trp Tyr Ile Glu Val 
        595                 600                 605             


Lys Asn Asn Asp Gln Ser Tyr Asn Ala Tyr Lys Asn Leu Leu Gln Leu 
    610                 615                 620                 


Ile Tyr Tyr His Ala Phe Leu Pro Glu Val Arg Glu Asn Glu Ala Leu 
625                 630                 635                 640 


Ile Thr Asp Phe Ile Asn Arg Thr Lys Glu Trp Asn Arg Lys Glu Thr 
                645                 650                 655     


Glu Glu Arg Leu Asn Thr Lys Asn Asn Lys Lys His Lys Asn Phe Asp 
            660                 665                 670         


Glu Asn Asp Asp Ile Thr Val Asn Thr Tyr Arg Tyr Glu Ser Ile Pro 
        675                 680                 685             


Asp Tyr Gln Gly Glu Ser Leu Asp Asp Tyr Leu Lys Val Leu Gln Arg 
    690                 695                 700                 


Lys Gln Met Ala Arg Ala Lys Glu Val Asn Glu Lys Glu Glu Gly Asn 
705                 710                 715                 720 


Asn Asn Tyr Ile Gln Phe Ile Arg Asp Val Val Val Trp Ala Phe Gly 
                725                 730                 735     


Ala Tyr Leu Glu Asn Lys Leu Lys Asn Tyr Lys Asn Glu Leu Gln Pro 
            740                 745                 750         


Pro Leu Ser Lys Glu Asn Ile Gly Leu Asn Asp Thr Leu Lys Glu Leu 
        755                 760                 765             


Phe Pro Glu Glu Lys Val Lys Ser Pro Phe Asn Ile Lys Cys Arg Phe 
    770                 775                 780                 


Ser Ile Ser Thr Phe Ile Asp Asn Lys Gly Lys Ser Thr Asp Asn Thr 
785                 790                 795                 800 


Ser Ala Glu Ala Val Lys Thr Asp Gly Lys Glu Asp Glu Lys Asp Lys 
                805                 810                 815     


Lys Asn Ile Lys Arg Lys Asp Leu Leu Cys Phe Tyr Leu Phe Leu Arg 
            820                 825                 830         


Leu Leu Asp Glu Asn Glu Ile Cys Lys Leu Gln His Gln Phe Ile Lys 
        835                 840                 845             


Tyr Arg Cys Ser Leu Lys Glu Arg Arg Phe Pro Gly Asn Arg Thr Lys 
    850                 855                 860                 


Leu Glu Lys Glu Thr Glu Leu Leu Ala Glu Leu Glu Glu Leu Met Glu 
865                 870                 875                 880 


Leu Val Arg Phe Thr Met Pro Ser Ile Pro Glu Ile Ser Ala Lys Ala 
                885                 890                 895     


Glu Ser Gly Tyr Asp Thr Met Ile Lys Lys Tyr Phe Lys Asp Phe Ile 
            900                 905                 910         


Glu Lys Lys Val Phe Lys Asn Pro Lys Thr Ser Asn Leu Tyr Tyr His 
        915                 920                 925             


Ser Asp Ser Lys Thr Pro Val Thr Arg Lys Tyr Met Ala Leu Leu Met 
    930                 935                 940                 


Arg Ser Ala Pro Leu His Leu Tyr Lys Asp Ile Phe Lys Gly Tyr Tyr 
945                 950                 955                 960 


Leu Ile Thr Lys Lys Glu Cys Leu Glu Tyr Ile Lys Leu Ser Asn Ile 
                965                 970                 975     


Ile Lys Asp Tyr Gln Asn Ser Leu Asn Glu Leu His Glu Gln Leu Glu 
            980                 985                 990         


Arg Ile Lys Leu Lys Ser Glu Lys  Gln Asn Gly Lys Asp  Ser Leu Tyr 
        995                 1000                 1005             


Leu Asp  Lys Lys Asp Phe Tyr  Lys Val Lys Glu Tyr  Val Glu Asn 
    1010                 1015                 1020             


Leu Glu  Gln Val Ala Arg Tyr  Lys His Leu Gln His  Lys Ile Asn 
    1025                 1030                 1035             


Phe Glu  Ser Leu Tyr Arg Ile  Phe Arg Ile His Val  Asp Ile Ala 
    1040                 1045                 1050             


Ala Arg  Met Val Gly Tyr Thr  Gln Asp Trp Glu Arg  Asp Met His 
    1055                 1060                 1065             


Phe Leu  Phe Lys Ala Leu Val  Tyr Asn Gly Val Leu  Glu Glu Arg 
    1070                 1075                 1080             


Arg Phe  Glu Ala Ile Phe Asn  Asn Asn Asp Asp Asn  Asn Asp Gly 
    1085                 1090                 1095             


Arg Ile  Val Lys Lys Ile Gln  Asn Asn Leu Asn Asn  Lys Asn Arg 
    1100                 1105                 1110             


Glu Leu  Val Ser Met Leu Cys  Trp Asn Lys Lys Leu  Asn Lys Asn 
    1115                 1120                 1125             


Glu Phe  Gly Ala Ile Ile Trp  Lys Arg Asn Pro Ile  Ala His Leu 
    1130                 1135                 1140             


Asn His  Phe Thr Gln Thr Glu  Gln Asn Ser Lys Ser  Ser Leu Glu 
    1145                 1150                 1155             


Ser Leu  Ile Asn Ser Leu Arg  Ile Leu Leu Ala Tyr  Asp Arg Lys 
    1160                 1165                 1170             


Arg Gln  Asn Ala Val Thr Lys  Thr Ile Asn Asp Leu  Leu Leu Asn 
    1175                 1180                 1185             


Asp Tyr  His Ile Arg Ile Lys  Trp Glu Gly Arg Val  Asp Glu Gly 
    1190                 1195                 1200             


Gln Ile  Tyr Phe Asn Ile Lys  Glu Lys Glu Asp Ile  Glu Asn Glu 
    1205                 1210                 1215             


Pro Ile  Ile His Leu Lys His  Leu His Lys Lys Asp  Cys Tyr Ile 
    1220                 1225                 1230             


Tyr Lys  Asn Ser Tyr Met Phe  Asp Lys Gln Lys Glu  Trp Ile Cys 
    1235                 1240                 1245             


Asn Gly  Ile Lys Glu Glu Val  Tyr Asp Lys Ser Ile  Leu Lys Cys 
    1250                 1255                 1260             


Ile Gly  Asn Leu Phe Lys Phe  Asp Tyr Glu Asp Lys  Asn Lys Ser 
    1265                 1270                 1275             


Ser Ala  Asn Pro Lys His Thr  
    1280                 1285 


<210>  1322
<211>  3411
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  1322
atgagaatat caaaagtaaa agtacaggac aataaccgaa aggtgatggt attgatgcat       60

cgtacaacag ttaatggggc cttggtctat gaaggtgaaa cgaatgtaag aacttcggaa      120

attcttccca aaaagaaatc agatagtttt gctttgagta ttgacaacaa aacgcttatc      180

aaacgagatt ctctaaaaga taaaaagcaa aaagacaact atgacatagt caaaaagatt      240

attaccaaac gagtgttacc tatacaaatt tcggatgaag atgtgttacc tgttttgaat      300

cataaatttc aaaacgaaat aatctattac aaaaacaatg aaccatacag ctttcggctc      360

gcttctttga ttgtagaagc ggtgaaagag agaaatcccg aaaaactaca accttatgat      420

gattggaaaa actggtatat ttcgaccaaa agctctcacc tgattcaatc gattgaacaa      480

aataaaattg atttgaacgg aactgacagt aaacgcaaaa cagccttgca agcttgggca      540

accaaatata ctacaagtgg aagtatcgat ttatcatttt atcataaatt gtatgctatc      600

gatactttgg cgggtgcgct tcataacaca gaaaaaggag agcttgatca agaaaaaaat      660

actccaaaaa atataaacct ttttcaccgc aacttaaaaa agacattgca aacacatcaa      720

aaaacagtgt tcggtacgcg tgaagcgcct aacgtgaaaa accgaaaaga cgagcaatta      780

gccatttatc atttggaagt agtgaaatac ctcgaacatt acttttctgt taaatccact      840

caacgaaaaa atacacaagc tgatattgac tattatttga aagcagagac tataaaaagt      900

accataacca atcaattgtc gaatgccgta agaaactacc tgctgcaaaa aggcaaagcc      960

gaacatcaca aatttgacaa cactactgat agttcccggc tgacagaaat taaaagaaat     1020

gaagcttttg tacttaatat gattgatgct tgtgcttttg ctgctaataa tattcggaat     1080

attgttgata cggagcaaac gaacgacatt ttgggtaaga cagaatatgt acaaagcttg     1140

aagaaaacaa acagagtcaa taaacaattg ttcaaattct tctttggaac agatttgccg     1200

gcgacagata gccataaagc aaaaacatta tgggcaatgc gtggagctgt acaacaaatt     1260

cgtaacgtgg tgattcatta taaacaaggt gcattggata ccatctttaa gatagaaaag     1320

tttgaatatc cagattttga agatcaatct tatactgata ccatttataa aacttgtttg     1380

gaaacggagc tgaaacaagt gcccgaagct tttgcacaac aactcaaaac agggggcgtg     1440

cttgcctact atccttacga tgatttgaag gcgctgctca atacagtgtc cttttctttg     1500

tgtcgtacag tagtaccttt tgccccaagc tttaagaaag tgcaaaaaca gggacaaaac     1560

tatcagaatg ctcaaaatga aaacttctac gacttagtac ttaaaagtta tttgccaaag     1620

gaaaaggatg cgagtaagga ggaggcgtat aatgcccgct atttcttgct aaagctaatt     1680

tacaacaatt tgtttttgcg aaactttacc gagaatagaa cacaattttc caaaacggta     1740

aattatattc tctcgcagaa caagaaacag gcagaagcct caaaaaatag taaagcctat     1800

gcttttgaag ccgtaaggca aatgaaggaa gaggaaagca tctccgatta tatggcgtat     1860

atacaaagtc aactgatgct tgaaaaaaat aaaaaagaag atgataaatc ggaagatacc     1920

catatcaatt ttgaaaagtt tgtattgcag gtatttatca aaggctttga tgattttcta     1980

caggacgaga agtttaaatt tatagctaaa ccttattttc aactgtcgaa agatgaaaca     2040

aaacaaactg agcaattgaa ccaattcgaa caaggaatca tcaacgaatg tcgggttcaa     2100

tcgcattcca taaatacgga agaggctacg catgttgctt tctttacctt ctgtaaactg     2160

cttgatgcaa cccacctaag caatctgcgc aacgaattga taaagtttaa acagtcggca     2220

aaacaatttg aattgagtca tatgcttgag ataatcgaat tgactttgct caatgcagat     2280

agagttcctg cggattatag aaaattgtat gaaaataaaa cagattgctt aaaccgtata     2340

ctttttttta tagcagatgg cattgatttt accaaatggt ccgatttgtt tgtacagacc     2400

gataacgaaa caccagtggt acatgccaat gtggaactta cagtgaaata tggcacagcc     2460

aaactattgg aacaattgat tgcaaaagat gtctcattca agttgtcaga atcaaacttt     2520

accttgtggg ataatgcgaa ggataccatt gaagtactga ttaataaacg attagattta     2580

cataaacaat gggaagaagc agttagaaaa gacaaagaag aaaaaaacaa gaagataaaa     2640

ccgagatcaa attttgctca gaagtttatc aataaagaag ggaatgatta ttccgaatta     2700

tgtgaatata ttgatgatta caattggcag gttaacaaac tgcattttgt acatcttagc     2760

cgtttgcacc atcttacgat cgatattctg ggacggatgg caggatttat cgcattattt     2820

gatcgagatt ttcaattatt tgatgcatct cgaactcaag acccttatca attaaaagct     2880

tttgtcagtt taagtaatat ggcaaaagat ttaaacaaac aaaatgatat tgccggcatt     2940

aaaggtatgg agtatgttgt aaaaagagat ggatcaccaa ttacagaagc cgatagaaat     3000

tcgcttaagg attgcattca aaacaaaagg gagtattttt caaaagtctt ttttctaaaa     3060

ggaagcaaac aatttgaagt tcgtaattat attgcacatt tcaattatct gtcaacaaca     3120

gccgaaaatt attctttaat tgatttacta aacgaaataa gagatctatt gagctacgat     3180

cgcaaattga aaaatgctgt caacaaagcc tttattgatt tatttgataa acaagggatg     3240

gaattgaagt tgaaattgaa tgccaatcac cgctttgaga tagagagtgt gaacccgaag     3300

ttgatctatc atcttggaac aaccctgaaa agcgaggatc ctataagctt ctaccaggtt     3360

aaactcgaat attgcaatat gtgcagagca ttattagaaa tgaaaaaata a              3411


<210>  1323
<211>  3765
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  1323
atggaagggg agggtgttat gaaactgaca aggcgcagga taggtcagga aagaaaaggt       60

gaaaaaataa aggctgcatt ttatcgtaat atatcccgtg gtttgttata tttggattcc      120

gaaaattgtg attatacgga atgcgttgta gaagccatgg actttgaacg ttcatgccgc      180

ggacgtatct tgaaaaacgc agataacgaa aaaaaccctt tttataaaat agttaaagga      240

ttgaccgata aagatacagg catattttat gaggccattg ttgatgatgg taatgatata      300

gatatattaa taaataacaa tataacaaga tatgggaagg aattacaagc tccgggttca      360

actgtttcat ttgaagaatt aataagagaa attcaatcag gtacatcaaa aagcgaaata      420

atattggaat tagaaaaaat taaaagaatg attcaagatg atatacaaaa gagtaaagac      480

cggcttataa agtcaattgc taataatcgt atccctttct ctttacaaag caacggactg      540

gttccttcaa gtaaaaaaat gaagtggctg tataaaatac tggacgataa caatatcctt      600

aagaagtatt gggacaagta cgaatatgaa aaactggagt caactttaat caaagctatt      660

gaggatttac aatataagaa tgcccgttta atttcccgaa ctgtttccgg agccatacgg      720

gattatcata gaagtctaaa aacgagatat actaattctt ctttggaggg gaaggcacga      780

agcgagcatg agattaactc cacagaaaac aacagcgaaa aagaggaatt cttattgttt      840

cttaaggctg tagagcagca ttttaaaaaa tatttccctg ttaaaggaaa acattctaca      900

gatgcttacg ataaagcact gtgtcaggca gaaaattata aattatactg taagttcaat      960

tttgttaaaa aagaagttaa tcgctcaatc atgaatcagt tagtatcggg actaattcag     1020

catggaaaac taatacacta ttttaataat gacggaacgt gggatgttga ttttctcaat     1080

tcgcacggac tttcatatat tcaagttgaa gaagctttca agaagtctct tatggcttct     1140

ctttcttggg gaattaaccg cttgacgtca ttttattatg atattaatga tacaagaata     1200

aatagtaatg aagaaagtat agtggatgat attttactag aaagtaagag acacaaagaa     1260

ttaagacgga actattataa tgatttaaga tctaatgaca taaagcagaa atactttaga     1320

gaaaaactag ctgcttgtta ttcgataata gcaaaagatg ataaagataa aatcagcgat     1380

gatataaata aactaatcgg tttggttgaa aggattcgga agagtgttgc tcatataaga     1440

catagtagtt ttcactacaa aaaagtaact ttaccagaga tgcttaatgc agtaaatatt     1500

aactatatca gagtagaaga attctttgca cgtgacatag aaaacctata caatgcattc     1560

cgtgaaaaga tacgaagtct gggtattgtc gaatattatt ccggcagtga tattgcggag     1620

tgttttgaaa aatgcggtat taaatttact ctctattcgc cgcagaattc tttgattcca     1680

tcatttaaaa agatatacaa aaaaggtgta aacctcaata aaggatatag agcaaaggaa     1740

aatcaaaagg agccgaacaa acataataaa catgatgagc aggtcaatag aaaagattta     1800

ttatggtatc ttgagatacc aaataatgaa caaggtctgc ttgcatataa aaatctttta     1860

caaattattt attatcattc gttcttgccc gaggttcaga aaaacgaatt attgattaca     1920

aactttatca ataatacaaa ggaatggaat cgtgtagaag caaaaaaaat atcagaaaga     1980

agaggaaaaa agaataaaag cagcaagcat aataatgaaa aagattttaa agcatatcgt     2040

tatgaggcaa ttccggatta tcagggagaa tctctggacg actatctaaa aatcattcaa     2100

agagagcaga tggcacaggc aaacgagatg gatgaaggta ccaccgacca taattattat     2160

atacggttta tgcaagatgt tgtcgtatgg gcattcggtg attatttaga aaaactaatg     2220

ggaagatatc gggatttttt acagaaacct gctttacagg atgttgatat atatgatgcg     2280

ttagaagagc tgctccccga agataaagaa aaagggaagt ttcccatggc ttgcagattt     2340

aacatgaaaa cagatgagaa tggaaatact atagtttata catttgagca gattaaagat     2400

caaataaaaa acaggaaaga cctattgtgt ttctacctgt ttttacgcct tttggatgca     2460

agggaaatcg ctaaattaca gcatcaattt atacgctatc gctgttcatt aatagaacga     2520

aggcttcctg acggtcgcag taatcagatt gaagatgaaa tagaactgtt taaagaattg     2580

gaagaattaa tggagcttgt tcgttatact atacctgaag tccatagttt gtacgggaaa     2640

aagaaatcag tgtttaatgt aatgatacaa ttgcatttca aagaattctt tgaagtgaaa     2700

gccttgaaaa acccggaagt agtgaatctt tattatcaat tggataagaa aacacctata     2760

ccaagaaagc acatggcact gttaatacgg tcagttccac ttcctttgta taaaaacatg     2820

tttaaaaact attattgtat taccgaaaat gactttaagg aatacattca gacaagcgaa     2880

gtaattgaag aaattcaaaa caaacaaaaa gaactacata aaatgcttga acgggctaga     2940

ttaaaatctc ctaatattga aaaaatgaag gataaaaact tatggtatat tgaggataag     3000

aatgttgttg agaaagtaat agaatatgaa gagaatctta gaataatagc aagatataat     3060

caaataaagc gtaagatcac atttgaatct ctttatagaa tttttcaaat tcatgttgat     3120

ctttgtgcac gtttaattgg ctatacccaa gattgggaac gggatatgta tttcttgtta     3180

aagagtttag agaacaaggg aataatacga aataatattc ttgatagaat atttagtagg     3240

aatatagtaa gggaactaaa taatattctc aatactaatg agaaaggaat attatataag     3300

ttatgttggc ataaggaact tacaatagat gatatgtata ataaaatgga cattagaaat     3360

tccattgcac atttaaatca ttttacgcaa tcttggaatt ttgataaacc atcactgatt     3420

gaaatgatta atgctttacg tgtcttacta cactatgacc gtaaacgcca aaatgcagta     3480

ttaaaaacca taaatgactt gctcttaaag gattatcgta ttaaaattga gtgggagaga     3540

aaggtacatg atacaggtga aataaaattt gatattaatg gtgatgtaat aaatgagcca     3600

attatacatc tgaaaaacat tcataaaggt gcaaagtgca aagtttataa taaagcttat     3660

atgattgaga aacaaagaga atggctatgc aacggtatcc gggaagaaat atatgataaa     3720

aactttcttg aatgcattga acgtctgttt aaattcaatt attaa                     3765


<210>  1324
<211>  1062
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1324

Met Asn Phe Glu Glu Asn Gly Asn Lys Tyr Leu Phe Gly Ala Phe Leu 
1               5                   10                  15      


Asn Thr Ala Tyr Asp Asn Tyr Asn Glu Val Ile Ser His Ile Tyr Asp 
            20                  25                  30          


Val Ile Arg Arg Ile Thr Asn Asn Asn Pro Thr Glu Gln Lys Ser Ser 
        35                  40                  45              


Ser Gln Ala Leu Ala Ser Glu Glu Pro Ile Ser Ser Glu Glu Lys Glu 
    50                  55                  60                  


Lys Met Phe Phe Val Cys Thr Ile Leu Ile Ala Gly Asn Ala Thr Ser 
65                  70                  75                  80  


Arg Lys Ile Glu Ser Ile Leu Lys Arg Ala Phe Pro Phe Trp Asp Asp 
                85                  90                  95      


Phe Ile Glu Ile His Ala Ser Leu Ser Ala Gln Leu Asp Lys Thr Glu 
            100                 105                 110         


Ser Ile Phe Gln Leu Gln Lys Asn Cys Val Glu Glu Leu Phe Thr Ala 
        115                 120                 125             


Leu Glu Ser Trp Arg Asn Tyr Thr Thr His Tyr Ile His Pro Glu Ala 
    130                 135                 140                 


Ile Ala Ser Pro Thr Ile Asn Leu Leu Leu Lys Ser Cys Phe Asn Gln 
145                 150                 155                 160 


Gly Ile Lys Glu Ile Lys Lys Arg Phe Asn Thr Lys Asp Glu Gln Leu 
                165                 170                 175     


Thr His Leu Tyr Glu Pro Glu Leu Phe His Asn Lys Glu Thr Asn Lys 
            180                 185                 190         


Asp Glu Ile Lys Cys Tyr His Pro Ala Asn Tyr Tyr Arg Phe Ala Asn 
        195                 200                 205             


Glu Asn Gly Leu Leu Thr Glu Lys Gly Leu Ala Phe Phe Thr Cys Leu 
    210                 215                 220                 


Phe Leu Tyr Lys Arg Glu Ser Tyr Leu Leu Leu Asn Gln Leu Lys Gly 
225                 230                 235                 240 


Phe Lys Arg Ala Asp Glu Glu Arg Tyr Arg Met Thr Leu Glu Ala Phe 
                245                 250                 255     


Thr Val Met Arg Phe Arg Ala Pro Lys Gln Leu Leu Lys Leu Gln Gln 
            260                 265                 270         


Gln Gln Leu Asp Lys Val Ser Leu Gly Ile Ser Met Ile Asn Glu Leu 
        275                 280                 285             


Ala Lys Cys Pro Lys Glu Leu Tyr Asp Cys Leu Glu Asn Glu Lys Arg 
    290                 295                 300                 


Arg Gln Phe Glu Val Tyr Pro Asp Thr Glu Thr Thr Leu Tyr Glu Gln 
305                 310                 315                 320 


Glu Ala Ile Gly Glu Leu Ile Arg Tyr Lys Asp Arg Tyr Glu Asn Leu 
                325                 330                 335     


Met Leu Lys Ala Leu Glu His Ser Ser Glu Cys Lys Tyr Met Gly Phe 
            340                 345                 350         


Tyr Leu Ser Leu Gly Lys Cys Tyr Met Lys Cys Tyr Glu Lys His Tyr 
        355                 360                 365             


Ile Asp Gly Thr Thr Asp Asn Arg Tyr Ile Val His Ser Leu Tyr Gly 
    370                 375                 380                 


Phe Gly Arg Leu Gln Asn Ala Ser Thr Asp His Lys Asn His Leu Ser 
385                 390                 395                 400 


Ser Phe Gly Glu Glu Leu Gln Thr His Ser Gln Leu Pro Val Cys His 
                405                 410                 415     


Phe Ala Thr Glu Asp Asp Ala Ala Asp Ser Pro Thr Ser Val Pro Tyr 
            420                 425                 430         


Ile Ser Glu Ser Tyr Pro Ser Tyr Val Leu Asn Asn Asn Asn Ile Gly 
        435                 440                 445             


Ile Lys Trp Leu Asn Ser Ser Glu Lys Thr Glu Tyr Pro Asn Phe Asn 
    450                 455                 460                 


Leu Asn Glu Gly Lys Val Ser Cys Pro Ala Pro Asp Tyr Trp Leu Ser 
465                 470                 475                 480 


Lys Tyr Glu Leu Pro Ala Met Ala Phe Tyr Ala Tyr Leu Lys Glu Lys 
                485                 490                 495     


His Lys Asn Lys Leu Gln Glu Tyr Pro Ser Ile Lys Glu Leu Ile Asp 
            500                 505                 510         


Gln Ser His Pro Glu Ala Thr Lys Thr Ser Ser Ser Thr Ile Lys Asp 
        515                 520                 525             


Arg Leu Glu Glu Arg Leu Lys Arg Tyr Lys Val Asp Ala Thr Lys Lys 
    530                 535                 540                 


Leu Lys Arg Leu Ala Glu Lys Pro Asp Gly Val Gln Ser Gly Arg Leu 
545                 550                 555                 560 


Ala Asp Glu Leu Ala Arg Asp Ile Leu Trp Leu Gln Pro Ser Ser Pro 
                565                 570                 575     


Lys Glu Gly Gly Lys Asp Lys Leu Thr Gly Ala Asn Phe Gln Ala Leu 
            580                 585                 590         


Gln Tyr Ala Leu Ala Arg Tyr Asp Phe Met Arg Thr Glu Leu Pro Arg 
        595                 600                 605             


Ile Leu Thr Ala Ala Arg Leu Thr Gly Ser Asn Asn Ala His Pro Phe 
    610                 615                 620                 


Leu Asp Lys Ile Asn Pro Gln Asp Tyr Ser Arg Leu Thr Ala Tyr Tyr 
625                 630                 635                 640 


Ala Gly Tyr Leu Thr Gln Lys Ile Val Tyr Ile Asp Lys Gln Leu Glu 
                645                 650                 655     


Lys Leu Ala Arg Gly Lys Val Asn Ile Gln Phe His Pro Thr Arg Lys 
            660                 665                 670         


Leu Ile Arg Gln Ser Gln Thr Asp Ser Val Glu His Glu Lys Glu Thr 
        675                 680                 685             


Val Phe Leu Pro Arg Asn Ile Phe Thr Glu Lys Ile Glu Gln Ala Leu 
    690                 695                 700                 


Cys Gln Ile Gln Gly Asn Phe Lys Leu Asn Ile Glu Lys Ala Arg Ile 
705                 710                 715                 720 


Ser Gly Lys Lys Leu Asn Ala Ser Lys Leu Ile Leu Ile Tyr Leu Glu 
                725                 730                 735     


Leu Tyr Leu Lys Asp Glu Val Pro Glu Phe Tyr Asn Ala Lys Arg Lys 
            740                 745                 750         


Tyr Pro Cys Leu Cys Tyr Pro Leu Thr Pro Ser Glu Lys Tyr Thr Leu 
        755                 760                 765             


Lys Glu Tyr Gln Asp Thr Glu Glu Arg Ser Lys Arg Ile Asp Arg Leu 
    770                 775                 780                 


Lys Cys Phe Tyr Asn Phe Lys Glu Val Ala Glu Lys Val Tyr Leu His 
785                 790                 795                 800 


Lys Glu Leu Ser Glu Asp Glu Asn Lys Arg Tyr Arg Lys Tyr Ile Glu 
                805                 810                 815     


Val Gln Lys Val Ile Asp Asn Glu Lys Ile Ile Arg Leu Arg Lys Val 
            820                 825                 830         


Gln Asp Ile Thr Leu Tyr Leu Trp Thr Arg Leu Phe Ile Glu Glu Asn 
        835                 840                 845             


Pro Glu Gln Ile Phe Phe Ser Lys Asn Glu Lys Pro Glu Asn Ser Leu 
    850                 855                 860                 


Phe Lys Leu Arg Glu Met Asn Asn Ala Ile Leu Asp Asn Thr Thr Ser 
865                 870                 875                 880 


Arg Lys Ile Asn Ile Asn Thr Pro Asn Gly Asn Val Ser Ile Glu Asp 
                885                 890                 895     


Glu Phe Lys Ile Lys Asp Tyr Gly Arg Val Thr Ala Leu Thr Thr Glu 
            900                 905                 910         


Lys Leu Pro Gln Ser Leu Ile Lys Phe Ile Ala Ile Leu Asn Lys Pro 
        915                 920                 925             


Leu Asn Lys Lys Asp Arg Pro Leu Leu Ser Tyr Asp Tyr Ile Tyr His 
    930                 935                 940                 


Glu Thr Asn Ala Phe Tyr Arg Tyr Arg Pro Glu Ile Ile Lys Met Ala 
945                 950                 955                 960 


Gln Asp Ile Glu Asn Lys Ile Ile Asn Asp Leu Lys Ile Asn Val Lys 
                965                 970                 975     


Pro Gln Ala Glu Ser Tyr Tyr Asn Phe Arg Arg Thr Ile Gln Lys Leu 
            980                 985                 990         


Glu Asn Lys Ser Arg Asp Ile Asn  Ile Glu Leu Leu Ile  Lys Ile Arg 
        995                 1000                 1005             


Asn Ala  Phe Cys His Asn Glu  Tyr Lys Glu Leu Asp  Asn Asp Gln 
    1010                 1015                 1020             


Tyr Lys  Tyr Leu Asn Ser Leu  Phe Lys Leu Ser Ser  Asp Ile Lys 
    1025                 1030                 1035             


Gln Thr  Asp Thr Leu Ala Tyr  Leu Leu Tyr Ile Leu  Phe Glu Thr 
    1040                 1045                 1050             


Glu Tyr  Gln Lys Val Met Ile  Leu Lys 
    1055                 1060         


<210>  1325
<211>  1062
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1325

Met Asn Phe Glu Glu Asn Gly Asn Lys Tyr Leu Phe Gly Ala Phe Leu 
1               5                   10                  15      


Asn Thr Ala Tyr Asp Asn Tyr Asn Glu Val Ile Ser His Ile Tyr Asp 
            20                  25                  30          


Val Ile Arg Arg Ile Thr Asn Asn Asn Pro Thr Glu Gln Lys Ser Ser 
        35                  40                  45              


Ser Gln Ala Leu Ala Ser Glu Glu Pro Ile Ser Ser Glu Glu Lys Glu 
    50                  55                  60                  


Lys Met Phe Phe Val Cys Thr Ile Leu Ile Ala Gly Asn Ala Thr Ser 
65                  70                  75                  80  


Arg Lys Ile Glu Ser Ile Leu Lys Arg Ala Phe Pro Phe Trp Asp Asp 
                85                  90                  95      


Phe Ile Glu Ile His Ala Ser Leu Ser Ala Gln Leu Asp Lys Thr Glu 
            100                 105                 110         


Ser Ile Phe Gln Leu Gln Lys Asn Cys Val Glu Glu Leu Phe Thr Ala 
        115                 120                 125             


Leu Glu Ser Trp Arg Asn Tyr Thr Thr His Tyr Ile His Pro Glu Ala 
    130                 135                 140                 


Ile Ala Ser Pro Thr Ile Asn Leu Leu Leu Lys Ser Cys Phe Asn Gln 
145                 150                 155                 160 


Gly Ile Lys Glu Ile Lys Lys Arg Phe Asn Thr Lys Asp Glu Gln Leu 
                165                 170                 175     


Thr His Leu Tyr Glu Pro Glu Leu Phe His Asn Lys Glu Thr Asn Lys 
            180                 185                 190         


Asp Glu Ile Lys Cys Tyr His Pro Ala Asn Tyr Tyr Arg Phe Ala Asn 
        195                 200                 205             


Glu Asn Gly Leu Leu Thr Glu Lys Gly Leu Ala Phe Phe Thr Cys Leu 
    210                 215                 220                 


Phe Leu Tyr Lys Arg Glu Ser Tyr Leu Leu Leu Asn Gln Leu Lys Gly 
225                 230                 235                 240 


Phe Lys Arg Ala Asp Glu Glu Arg Tyr Arg Met Thr Leu Glu Ala Phe 
                245                 250                 255     


Thr Val Met Arg Phe Arg Ala Pro Lys Gln Leu Leu Lys Leu Gln Gln 
            260                 265                 270         


Gln Gln Leu Asp Lys Val Ser Leu Gly Ile Ser Met Ile Asn Glu Leu 
        275                 280                 285             


Ala Lys Cys Pro Lys Glu Leu Tyr Asp Cys Leu Glu Asn Glu Lys Arg 
    290                 295                 300                 


Arg Gln Phe Glu Val Tyr Pro Asp Thr Glu Thr Thr Leu Tyr Glu Gln 
305                 310                 315                 320 


Glu Ala Ile Gly Glu Leu Ile Arg Tyr Lys Asp Arg Tyr Glu Asn Leu 
                325                 330                 335     


Met Leu Lys Ala Leu Glu His Ser Ser Glu Cys Lys Tyr Met Gly Phe 
            340                 345                 350         


Tyr Leu Ser Leu Gly Lys Cys Tyr Met Lys Cys Tyr Glu Lys His Tyr 
        355                 360                 365             


Ile Asp Gly Thr Thr Asp Asn Arg Tyr Ile Val His Ser Leu Tyr Gly 
    370                 375                 380                 


Phe Gly Arg Leu Gln Asn Ala Ser Thr Asp His Lys Asn His Leu Ser 
385                 390                 395                 400 


Ser Phe Gly Glu Glu Leu Gln Thr His Ser Gln Leu Pro Val Cys His 
                405                 410                 415     


Phe Ala Thr Glu Asp Asp Ala Ala Asp Ser Pro Thr Ser Val Pro Tyr 
            420                 425                 430         


Ile Ser Glu Ser Tyr Pro Ser Tyr Val Leu Asn Asn Asn Asn Ile Gly 
        435                 440                 445             


Ile Lys Trp Leu Asn Ser Ser Glu Lys Thr Glu Tyr Pro Asn Phe Asn 
    450                 455                 460                 


Leu Asn Glu Gly Lys Val Ser Cys Pro Ala Pro Asp Tyr Trp Leu Ser 
465                 470                 475                 480 


Lys Tyr Glu Leu Pro Ala Met Ala Phe Tyr Ala Tyr Leu Lys Glu Lys 
                485                 490                 495     


His Lys Asn Lys Leu Gln Glu Tyr Pro Ser Ile Lys Glu Leu Ile Asp 
            500                 505                 510         


Gln Ser His Pro Glu Ala Thr Lys Thr Ser Ser Ser Thr Ile Lys Asp 
        515                 520                 525             


Arg Leu Glu Glu Arg Leu Lys Arg Tyr Lys Val Asp Ala Thr Lys Lys 
    530                 535                 540                 


Leu Lys Arg Leu Ala Glu Lys Pro Asp Gly Val Gln Ser Gly Arg Leu 
545                 550                 555                 560 


Ala Asp Glu Leu Ala Arg Asp Ile Leu Trp Leu Gln Pro Ser Ser Pro 
                565                 570                 575     


Lys Glu Gly Gly Lys Asp Lys Leu Thr Gly Ala Asn Phe Gln Ala Leu 
            580                 585                 590         


Gln Tyr Ala Leu Ala Arg Tyr Asp Phe Met Arg Thr Glu Leu Pro Arg 
        595                 600                 605             


Ile Leu Thr Ala Ala Arg Leu Thr Gly Ser Asn Asn Ala His Pro Phe 
    610                 615                 620                 


Leu Asp Lys Ile Asn Pro Gln Asp Tyr Ser Arg Leu Thr Ala Tyr Tyr 
625                 630                 635                 640 


Ala Gly Tyr Leu Thr Gln Lys Ile Val Tyr Ile Asp Lys Gln Leu Glu 
                645                 650                 655     


Lys Leu Ala Arg Gly Lys Val Asn Ile Gln Phe His Pro Thr Arg Lys 
            660                 665                 670         


Leu Ile Arg Gln Ser Gln Thr Asp Ser Val Glu His Glu Lys Glu Thr 
        675                 680                 685             


Val Phe Leu Pro Arg Asn Ile Phe Thr Glu Lys Ile Glu Gln Ala Leu 
    690                 695                 700                 


Cys Gln Ile Gln Gly Asn Phe Lys Leu Asn Ile Glu Lys Ala Arg Ile 
705                 710                 715                 720 


Ser Gly Lys Lys Leu Asn Ala Ser Lys Leu Ile Leu Ile Tyr Leu Glu 
                725                 730                 735     


Leu Tyr Leu Lys Asp Glu Val Pro Glu Phe Tyr Asn Ala Lys Arg Lys 
            740                 745                 750         


Tyr Pro Cys Leu Cys Tyr Pro Leu Thr Pro Ser Glu Lys Tyr Thr Leu 
        755                 760                 765             


Lys Glu Tyr Gln Asp Thr Glu Glu Arg Ser Lys Arg Ile Asp Arg Leu 
    770                 775                 780                 


Lys Cys Phe Tyr Asn Phe Lys Glu Val Ala Glu Lys Val Tyr Leu His 
785                 790                 795                 800 


Lys Glu Leu Ser Glu Asp Glu Asn Lys Arg Tyr Arg Lys Tyr Ile Glu 
                805                 810                 815     


Val Gln Lys Val Ile Asp Asn Glu Lys Ile Ile Arg Leu Arg Lys Val 
            820                 825                 830         


Gln Asp Ile Thr Leu Tyr Leu Trp Thr Arg Leu Phe Ile Glu Glu Asn 
        835                 840                 845             


Pro Glu Gln Ile Phe Phe Ser Lys Asn Glu Lys Pro Glu Asn Ser Leu 
    850                 855                 860                 


Phe Lys Leu Arg Glu Met Asn Asn Ala Ile Leu Asp Asn Thr Thr Ser 
865                 870                 875                 880 


Arg Lys Ile Asn Ile Asn Thr Pro Asn Gly Asn Val Ser Ile Glu Asp 
                885                 890                 895     


Glu Phe Lys Ile Lys Asp Tyr Gly Arg Val Thr Ala Leu Thr Thr Glu 
            900                 905                 910         


Lys Leu Pro Gln Ser Leu Ile Lys Phe Ile Ala Ile Leu Asn Lys Pro 
        915                 920                 925             


Leu Asn Lys Lys Asp Arg Pro Leu Leu Ser Tyr Asp Tyr Ile Tyr His 
    930                 935                 940                 


Glu Thr Asn Ala Phe Tyr Arg Tyr Arg Pro Glu Ile Ile Lys Met Ala 
945                 950                 955                 960 


Gln Asp Ile Glu Asn Lys Ile Ile Asn Asp Leu Lys Ile Asn Val Lys 
                965                 970                 975     


Pro Gln Ala Glu Ser Tyr Tyr Asn Phe Arg Arg Thr Ile Gln Lys Leu 
            980                 985                 990         


Glu Asn Lys Ser Arg Asp Ile Asn  Ile Glu Leu Leu Ile  Lys Ile Arg 
        995                 1000                 1005             


Asn Ala  Phe Cys His Asn Glu  Tyr Lys Glu Leu Asp  Asn Asp Gln 
    1010                 1015                 1020             


Tyr Lys  Tyr Leu Asn Ser Leu  Phe Lys Leu Ser Ser  Asp Ile Lys 
    1025                 1030                 1035             


Gln Thr  Asp Thr Leu Ala Tyr  Leu Leu Tyr Ile Leu  Phe Glu Thr 
    1040                 1045                 1050             


Glu Tyr  Gln Lys Val Met Ile  Leu Lys 
    1055                 1060         


<210>  1326
<211>  1138
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1326

Met Glu Thr Gln Glu Asn Glu Leu Phe Glu Asn Arg Arg Arg Thr Leu 
1               5                   10                  15      


Ala Asp Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Leu Ala Arg Leu 
            20                  25                  30          


Asn Ile Phe Ser Ile Asn Asn Tyr Leu Ala Lys Glu Phe Gln Gln Thr 
        35                  40                  45              


Glu Leu Lys Asp Asp Glu Leu Ile Gln Asn Gly Phe Ile Cys Ile Pro 
    50                  55                  60                  


Ser Gln Lys Asn Arg Asn Asp Asn Lys Leu Phe Glu Arg Leu Ile Arg 
65                  70                  75                  80  


Leu Met Pro Val Ile Lys Gln Phe Asp Ala Ala Arg Leu Pro Glu Asp 
                85                  90                  95      


Glu Gln Gln Ser Gly Gln Ala Glu Gly Lys Asp Ile Lys Ala Met Ala 
            100                 105                 110         


Lys Thr Leu Lys Ala Leu Phe Lys Asp Met Gln Glu Phe Arg Asn Asp 
        115                 120                 125             


Tyr Thr His Phe Tyr Ala Thr Asp Lys Gln Glu Cys Arg Lys Leu Thr 
    130                 135                 140                 


Val Leu Pro Glu Thr Ala Thr Phe Leu Lys Ala Ser Phe Ala Arg Ala 
145                 150                 155                 160 


Ile Glu Tyr Ser Lys Ser Arg Phe Lys Asp Val Leu Ser Glu Asp Asp 
                165                 170                 175     


Tyr Ser Ile Val Ala Gly Lys Glu Leu Val Ser Asp Asp Asn Thr Ile 
            180                 185                 190         


Thr Thr Glu Gly Leu Val Phe Leu Thr Ser Leu Phe Leu Asp Arg Glu 
        195                 200                 205             


Asn Ala Phe Gln Phe Ile Gly Lys Val Gln Gly Leu Lys Gly Thr Gln 
    210                 215                 220                 


Phe Lys Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ala Tyr Cys Val 
225                 230                 235                 240 


Arg Leu Pro His Asp Lys Leu Ile Ser Asp Asn Pro Ile Gln Ala Leu 
                245                 250                 255     


Leu Phe Asp Met Leu Asn Glu Leu Asn Lys Cys Pro Lys Lys Leu Tyr 
            260                 265                 270         


Asn Val Leu Ser Glu Glu Val Lys Lys Glu Phe Arg Pro Glu Leu Ser 
        275                 280                 285             


Glu Ser Gly Ile Glu Asn Met Leu Ala Asn Ser Phe Asn Asp Glu Glu 
    290                 295                 300                 


Arg Glu Lys Leu Leu Asp Glu Ile Glu Tyr Lys Glu Tyr Ile Glu Gln 
305                 310                 315                 320 


Leu Thr Ile Arg Val Arg His Ser Asn Arg Phe His Tyr Phe Ala Met 
                325                 330                 335     


Arg Phe Ile Asp Glu Gln Glu Leu Trp Pro Gly Ile Arg Phe Gln Ile 
            340                 345                 350         


Asp Leu Gly Lys Tyr Thr Leu Thr Gln Tyr Asp Lys Gln Val Leu Gly 
        355                 360                 365             


Glu Ser Ile Pro Arg Ser Val Val Glu Asn Thr Arg Ala Phe Gly Arg 
    370                 375                 380                 


Leu Ser Asn Phe Leu Thr Ala Asp Pro Asp Ser Leu Glu Gln Arg Ile 
385                 390                 395                 400 


Asp Val Asp His Arg Ala Asn Gly Phe Glu Gln Phe Ala Pro His Tyr 
                405                 410                 415     


Asn Ala Asp Ile Asn Lys Ile Gly Ile Ala Phe Thr Glu Lys Glu Gln 
            420                 425                 430         


Leu Pro Tyr Ile Val Arg Thr Lys Asn Ala Glu Thr Asn Arg Val Lys 
        435                 440                 445             


Tyr Ser Phe Lys Gln Pro Gln Pro Asp Ala Phe Ile Ser Leu His Glu 
    450                 455                 460                 


Leu Ala Lys Ala Ile Leu Leu Glu Gln Leu Gln Pro Gly Glu Ser Glu 
465                 470                 475                 480 


Lys Leu Ile Arg Ala Phe Cys Ser Thr Ala Glu Asn Lys Leu Phe Asn 
                485                 490                 495     


Pro Glu Phe Ile Glu Ser Ile Lys Trp Lys Leu Pro Asp Trp Lys Pro 
            500                 505                 510         


Phe Gln Lys Gln Cys Asp Thr Lys Lys Ser Arg Ala Tyr Ile Thr Lys 
        515                 520                 525             


Arg Asn Met Phe Ala Tyr Ala Pro Arg Asp Arg Lys Lys Leu Leu Asp 
    530                 535                 540                 


Glu Leu Leu Ala Pro Tyr Gly Leu Asn Arg Lys Gln Val Pro Glu Arg 
545                 550                 555                 560 


Ile Leu Asn Tyr Trp Leu Asn Ile Glu Glu Val His Asp Ala Arg Ser 
                565                 570                 575     


Val Asn Glu Arg Leu Leu Leu Met Lys Arg Asp Gly Leu Gln Arg Leu 
            580                 585                 590         


Lys Gln Leu Glu Lys His Arg Lys Asp Pro Ser Ile Arg Ile Pro Lys 
        595                 600                 605             


Val Gly Glu Met Ala Thr Phe Leu Ala Arg Asp Ile Val Asp Met Met 
    610                 615                 620                 


Ile Asp Gly Thr Lys Lys Lys Lys Ile Thr Ser Ile Tyr Tyr Asp Lys 
625                 630                 635                 640 


Met Gln Glu Cys Leu Ala Phe Tyr Ala Asp Ala Glu Lys Lys Gln Gln 
                645                 650                 655     


Phe Ile Asp Leu Val Cys Glu Leu Asp Leu Asn Asp Met Gly Gly His 
            660                 665                 670         


Pro Phe Leu Lys Asn Leu Asn Leu Glu Ser Ile Gly Lys Thr Ser Glu 
        675                 680                 685             


Phe Tyr Ser Arg Tyr Leu Glu Ala Lys Val Gln Lys Asp Val Ser Glu 
    690                 695                 700                 


Tyr Asn Tyr Lys Lys Cys Arg Glu Val Thr Lys Asn Val Ser Trp Met 
705                 710                 715                 720 


Val Lys Thr Phe Glu Thr Lys Val Trp Asn Glu Glu Ile Lys Lys Asn 
                725                 730                 735     


Leu Thr Glu Tyr Arg Ile Pro Ala Asp Lys Arg Asn Ile Pro Tyr Ser 
            740                 745                 750         


Ile Leu Gln Trp Glu Lys Glu Ala Ser Thr Leu Glu Glu Trp Leu His 
        755                 760                 765             


Ala Ile Asn His Gly Lys Gln Glu Gly Asp Arg Lys Arg Pro Ile Asp 
    770                 775                 780                 


Leu Pro Thr Asp Leu Phe Asp Ala Arg Leu Cys Glu Leu Met Lys Ala 
785                 790                 795                 800 


Gln Leu Gln Glu Lys Gly Gln Ser Pro Thr Glu Thr Ala Lys Tyr Asn 
                805                 810                 815     


Glu Leu Leu Lys Gln Trp Trp Ser Leu Arg Glu Asp Glu Thr Gln Pro 
            820                 825                 830         


Phe Tyr Asn Gly Ala Arg His Tyr Val Ile Lys Glu Glu Ala Val Cys 
        835                 840                 845             


Phe Thr Pro Gly Ala Gln Pro Arg Leu Thr Ser Cys Tyr Ala Asp Ala 
    850                 855                 860                 


Val Glu Glu Ala Tyr Asn Arg Leu Ser Ala Glu Arg Asn Ile Ala Arg 
865                 870                 875                 880 


Arg Asn Asp Lys Arg Leu Pro Pro Ile Gln Lys Gln Glu Met Glu Lys 
                885                 890                 895     


Thr Phe Lys Arg Ala Leu Tyr Asp Thr Glu Lys Glu Ile Arg Leu Leu 
            900                 905                 910         


Gly Glu Gln Asp Arg Ile Leu Leu Leu Met Ala Glu Gln Leu Ser Pro 
        915                 920                 925             


Gly Lys Glu Thr Leu Lys Leu Lys Thr Val Ala Gln Glu Leu Thr Arg 
    930                 935                 940                 


Ser Arg Glu Ile Lys Lys Glu Phe Ser Tyr Ile Ser Asn Tyr Asn Thr 
945                 950                 955                 960 


Gln Gly Glu Arg Leu Lys Lys Glu Glu Val Pro Pro Gln Leu Thr Leu 
                965                 970                 975     


Thr Val Thr Gly Ile Met Gln Leu Lys Asn Ser Asn Asp Leu Asn Arg 
            980                 985                 990         


Phe Ala His Asp Arg Arg Met Pro  Glu Leu Val Ala Tyr  Leu Pro Asn 
        995                 1000                 1005             


Ala Thr  Val Asp Ala Asp Lys  Leu Arg Tyr Glu Leu  Met Asp Tyr 
    1010                 1015                 1020             


Asn Lys  Ala Arg Leu Thr Val  Phe Asp Ala Val Phe  Lys Leu Glu 
    1025                 1030                 1035             


Lys Ala  Leu Ile Asp Gln Asp  Arg Glu Gly Val Ile  Thr Leu Phe 
    1040                 1045                 1050             


Thr Asp  Glu Gln Gly Glu Ala  Lys Gln Ser Arg Met  Gln His Lys 
    1055                 1060                 1065             


Pro Tyr  Leu Gln Trp Leu Leu  Asn Lys Gly Val Ile  Thr Gln Pro 
    1070                 1075                 1080             


Glu Ser  Cys Tyr Leu Asn Met  Leu Arg Asn Ser Phe  Ser His Asn 
    1085                 1090                 1095             


Gln Phe  Pro His Ile Ala Val  Ala Leu Asn Gly Thr  Glu Val Val 
    1100                 1105                 1110             


Pro Val  Lys Asn Ile Ala Ser  Thr Ile Ala Gly Ala  Tyr Lys Gln 
    1115                 1120                 1125             


Lys Ile  Glu Thr Ile Ile Gly  Lys Ile Gly 
    1130                 1135             


<210>  1327
<211>  1047
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1327

Met Glu Thr Glu Val Thr Ala Gln Asn Asn Ser Leu Thr Leu Thr Asn 
1               5                   10                  15      


Asn Pro Tyr Tyr Phe Ala His Tyr Ala Asn Met Ala Arg His Asn Ala 
            20                  25                  30          


Tyr Ile Val Leu Asn Glu Ile Asn Glu Lys Ile Tyr Asn Asn Lys Val 
        35                  40                  45              


Lys Ile Pro Glu Asp Gly Leu Ser Glu Cys Lys Leu Val Asn Ser Phe 
    50                  55                  60                  


Ser Lys Lys Asn Lys Lys Ala Asp Glu Tyr Ala Arg Ile Ile Lys Leu 
65                  70                  75                  80  


Leu Thr Glu His Tyr Pro Phe Ile Arg Phe Tyr Ala Asp Ser Ser Lys 
                85                  90                  95      


Glu Met Gly Asn Ile Pro Leu Lys Ala Tyr Leu Asp Ile Leu Asp Lys 
            100                 105                 110         


Ile Arg Asn Glu Asn Asn His Tyr Asn His Thr Ala Glu Arg Lys Glu 
        115                 120                 125             


Ile Ser Lys Ile Gln Glu Leu Phe Leu Phe Ala Lys Glu Lys Ala Lys 
    130                 135                 140                 


Gly Arg Met Ile Glu Phe Ser Pro Glu Asp Phe Asp His Leu Asn Asn 
145                 150                 155                 160 


Ser Lys Tyr Tyr Ala Met Thr Glu Asp Gly Ser Leu Thr Asn Thr Gly 
                165                 170                 175     


Ile Tyr Phe Phe Leu Cys Leu Phe Leu Glu Lys Lys His Ala Phe Gln 
            180                 185                 190         


Phe Leu Ser Arg Ile Lys Gly Phe Lys His Arg Glu Gln Lys Ser His 
        195                 200                 205             


Arg Ala Thr Leu Glu Thr Phe Thr Gln Leu Cys Cys Arg Leu Pro Tyr 
    210                 215                 220                 


Pro Lys Leu Glu Ser Ser Asp Val Ala Leu Asp Met Leu Asn Glu Ile 
225                 230                 235                 240 


Ala Arg Cys Pro Asn Ala Leu Tyr Gly Val Leu Glu Asn Lys Asp Lys 
                245                 250                 255     


Glu Thr Phe Lys Val Glu Phe Lys Asn Gly Ala Thr Asn Asn Glu Met 
            260                 265                 270         


Glu Val Pro Glu Pro Val Met Lys Arg His Asp Asp Arg Phe Pro Tyr 
        275                 280                 285             


Phe Ala Leu Arg Tyr Phe Asp Lys Ser Gln Ala Leu Asp Gly Ile Thr 
    290                 295                 300                 


Ser His Leu Gln Leu Gly Arg Arg Ile Val Ser Asp Pro His Gln Lys 
305                 310                 315                 320 


Lys Ile Gly Ala Glu Val Arg Thr His Glu Ile Leu Lys Asp Met Arg 
                325                 330                 335     


Thr Ala His Gln Leu Ala Tyr Phe Glu Thr Asp Ala Ala Lys Glu Phe 
            340                 345                 350         


Tyr Thr Asn Ile Pro Val Val Glu His Tyr Ala Pro Gln Tyr Arg Ile 
        355                 360                 365             


Val Gly Asn Arg Ile Gly Leu Phe Phe Asp Tyr Glu Cys Trp Gly Lys 
    370                 375                 380                 


Tyr Thr Val Pro Lys Glu Asn Val Lys Pro Asp Ala Ile Ile Ser Ile 
385                 390                 395                 400 


His Asp Leu Gly Ala Leu Tyr Phe Tyr Asn Arg Leu Tyr Lys Glu Gly 
                405                 410                 415     


Ser Val Lys Gln Ser Pro Lys Glu Leu Met Lys Ser Tyr Leu Glu Asn 
            420                 425                 430         


Met Asn Arg Leu Phe Asp Asp Val Lys Lys Gly Asn Ile Lys Pro Val 
        435                 440                 445             


Asn Asp Gly Glu Lys Leu Thr Pro Leu Phe Lys Ile Lys Asp Lys Glu 
    450                 455                 460                 


Asp Glu Tyr Glu Ile Arg Leu Glu Asn Leu Lys Glu Leu Ser Ala Leu 
465                 470                 475                 480 


Leu Gln Thr Glu Leu Asp Lys Arg Gly Tyr Gly Ile Glu Val Lys Asn 
                485                 490                 495     


Leu Pro Asp Val Cys Arg Glu Tyr Leu Leu Gly Tyr Lys Glu Ser Ser 
            500                 505                 510         


Ala Lys Asp Lys Ala Lys Arg Arg Phe Lys Arg Met Leu Arg Glu Thr 
        515                 520                 525             


Gln Phe Ala Leu Lys Lys Val Glu Arg Val Leu Ile Gln Glu Thr Ser 
    530                 535                 540                 


Leu Leu Ala Ser Gly Leu Lys Val Gly Glu Met Ala Gln Glu Leu Ala 
545                 550                 555                 560 


Arg Asp Ile Val Phe Leu Ile Lys Pro Lys Ile Val Lys Lys Ile Ile 
                565                 570                 575     


Lys Ser Gly Thr Asp Ala Gly Lys Glu Val Glu Cys Lys Gln Lys Ile 
            580                 585                 590         


Asn Asn Met Glu Phe Asp Val Leu Gln Lys Met Leu Ala Phe Tyr Pro 
        595                 600                 605             


Val Tyr Lys Glu Glu Ile Glu His Phe Leu Trp Thr Met Val Asn Lys 
    610                 615                 620                 


Arg Asp Pro Asn Ala Phe Ser His Pro Phe Leu Phe Arg Ala Leu Leu 
625                 630                 635                 640 


Lys Ile Lys Thr Cys Arg Asn Leu Asn Asp Phe Tyr Lys Glu Tyr Tyr 
                645                 650                 655     


Leu His Lys Gln Arg Trp Ile Glu Gly Val Ser Lys Ser Ile Thr Pro 
            660                 665                 670         


Glu Val Leu Arg Asp Asn Glu Tyr Phe Leu Lys Leu Glu Asn Gly Asn 
        675                 680                 685             


Ala Phe Pro His Asn Tyr Asn Gly Glu Ala Ile Phe Ile Pro Ser Gly 
    690                 695                 700                 


Phe Phe Asn Lys Glu Ile Thr Arg Ala Met Val Gln Ile Gly Tyr Lys 
705                 710                 715                 720 


Ile Glu Asn Pro Glu Lys Gly Ala Asn Ala Ala Tyr Trp Ile Lys Gln 
                725                 730                 735     


Tyr Phe Glu Gly Lys Ser Gln Pro Phe Tyr Asn Leu Pro Arg Tyr Tyr 
            740                 745                 750         


Asn Glu Ser Leu Gly Gly Lys Glu Pro Val Tyr Ile Glu Arg Asp Lys 
        755                 760                 765             


Leu Lys Lys Gln Ile Leu Glu Gly Asp Phe Asn Arg Leu Thr Glu Asp 
    770                 775                 780                 


Glu Gln Lys Arg Arg Lys Val Leu Ala Lys Arg Ile Arg Glu Asn Glu 
785                 790                 795                 800 


Ser Glu Ile Leu Thr Asn Gln Thr Asn Asp Arg Val Met Tyr Leu Met 
                805                 810                 815     


Ala Met Glu Leu Ile Asp Ser Glu Asn Pro Leu Lys Lys Asn Glu Ile 
            820                 825                 830         


Val Ser Val Gly Tyr Asn Ile Lys Glu Gly Thr Asn Leu Leu Asp Asn 
        835                 840                 845             


Asn Lys Val Ser Trp Asn Ile Gln Gly Arg Arg Val Val Ala Glu Leu 
    850                 855                 860                 


Pro Ile Lys Arg Tyr Gly Glu Tyr Arg Arg Phe Leu Lys Asp Arg Arg 
865                 870                 875                 880 


Leu Glu Asn Leu Leu Lys Tyr Tyr Pro Glu Gly Lys Glu Leu Gln Leu 
                885                 890                 895     


Gly Thr Leu Lys Ser Gly Glu Val Glu Glu Lys Gly Lys Lys Tyr Thr 
            900                 905                 910         


Asn Ser Asn Leu Val Asp Glu Leu Glu Leu Phe Asp Leu Lys Arg Asn 
        915                 920                 925             


Glu Leu Met Glu Gln Val Tyr Leu Phe Glu Lys Ile Leu Cys Thr Asn 
    930                 935                 940                 


Tyr Ala Asp Lys Ile Lys Ala Val Leu Pro Asp Lys Glu Arg Asn Lys 
945                 950                 955                 960 


Pro Tyr Ile Glu His Tyr His Cys Leu Met Tyr Ala Lys Asn Glu Met 
                965                 970                 975     


Lys Leu Phe Lys Glu Val Gly Glu Leu Glu His Glu His Phe Asn Glu 
            980                 985                 990         


Leu Arg Asn Lys Ile Ser His Asn  Gln Met Pro Tyr Thr  Asp Trp Leu 
        995                 1000                 1005             


Met Glu  Arg Val Ile Ala Asn  Lys Glu Glu Pro Met  Ile Thr Asn 
    1010                 1015                 1020             


Arg Ile  Val Asp Leu Ile Leu  Ser Ile Tyr Lys Glu  Leu Asn Ser 
    1025                 1030                 1035             


Gln Leu  Val Ile Ile Thr Asn  Ser Lys 
    1040                 1045         


<210>  1328
<211>  1199
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1328

Met Asn Thr Phe Ile Asp Ser Phe Ile Arg Arg Val Gln Ile Gln Asn 
1               5                   10                  15      


Gln Asn Gln Ser Trp Pro Lys Arg Pro Lys Tyr Val Arg Pro Val Glu 
            20                  25                  30          


Asn Ile Arg Pro Asp Asp Leu Ala Phe Gln Ser His Phe Thr Ala Tyr 
        35                  40                  45              


Leu Asn Met Ala Arg Gln Asn Cys Cys Ile Ile Leu Gly His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Gly Phe Lys Ala Ser Ser Val Lys Asp Thr Thr Leu Thr 
65                  70                  75                  80  


Ser Ser Pro Leu Leu Gly Gln Asn Gly Leu Leu Ser Pro Lys Lys Glu 
                85                  90                  95      


Val Ser Asp Leu Ile Arg Gly Arg Leu Leu Ser Ala Phe Pro Met Leu 
            100                 105                 110         


Asp Pro Met Ile Arg Tyr Arg Lys Ala Val Asp Lys Glu Lys Asp Asp 
        115                 120                 125             


Tyr Ala Arg Ile Ile Ile Thr Ser Glu Asp Val Ser Glu Met Leu Arg 
    130                 135                 140                 


Asp Leu Leu Asp Val Leu Ser Tyr Tyr Arg Asp Met Ala Ser His Val 
145                 150                 155                 160 


Val Phe Asn Asp Asp Arg Ser Val Ser Ala Glu Phe Ala Ser Lys Glu 
                165                 170                 175     


Lys Lys Val Ala Glu Cys Leu Asn Tyr Met Met Thr Val Ser Leu Arg 
            180                 185                 190         


Ile Val Lys Asp Arg Phe Ser Leu Ala Val Ser Asp Leu Asp Phe Tyr 
        195                 200                 205             


Asn Arg Asn Arg Tyr Met Met Val Asn Arg Lys Pro Leu Leu Asn Ala 
    210                 215                 220                 


Gly Phe Ala His Ala Val Arg Thr Glu Asp Tyr Arg Leu Thr Leu Met 
225                 230                 235                 240 


Gly Leu Val Leu Leu Cys Cys Gln Phe Ile Glu Lys Gln Tyr Ala Ser 
                245                 250                 255     


Met Phe Phe Asp Ala Leu Asp Lys His Ser Asn Gly Ala Arg Phe Tyr 
            260                 265                 270         


Gly Ile Ala Asp Ala Met Pro Met Val Asn Val Gly Thr Lys Asp Lys 
        275                 280                 285             


Pro Lys Lys Ile Pro Met Tyr Thr Gly Asp Glu Ala Gln Lys Gln Val 
    290                 295                 300                 


Gln Lys Gln Arg Met Ala Leu Arg Glu Ala Tyr Ser Val Tyr Arg Val 
305                 310                 315                 320 


Arg Ile Pro Lys Glu Arg Leu Glu Ser Thr Arg Ser Asp Met Ala Leu 
                325                 330                 335     


Ala Leu Asp Ile Leu Asn Glu Leu Gly Lys Cys Pro Glu Glu Leu Phe 
            340                 345                 350         


Glu His Leu Ser Pro Glu Asp Arg Glu Ser Phe Lys Asn Glu Glu Gly 
        355                 360                 365             


Val Leu Met Lys Arg Tyr Ser Asp Arg Phe Pro Gln Leu Ala Leu Arg 
    370                 375                 380                 


Trp Leu Asp Glu Asn Glu Lys Phe Asn Asn Leu Arg Phe His Val Thr 
385                 390                 395                 400 


Phe Gly Lys Tyr Arg Trp Leu Phe Cys Gln Asp Lys Lys Cys Ala Asp 
                405                 410                 415     


Gly Ser Val Arg Pro Arg Trp Leu Gln Lys Glu Leu Asn Gly Phe Gly 
            420                 425                 430         


Arg Ile Gln Thr Val Glu Arg Lys Arg Thr Gly Leu Glu Pro Gly Trp 
        435                 440                 445             


Asp Gly Thr Gly Leu Ile Arg Lys Phe Glu Glu Val Val Thr Asp Glu 
    450                 455                 460                 


Val Gln Lys Glu Pro Tyr Ile Thr Asp Phe Arg Thr Gln Tyr Leu Phe 
465                 470                 475                 480 


Asn Arg Asp Lys Ile Gly Ile Ser Leu Ser Glu Tyr Met Pro Gly Ile 
                485                 490                 495     


Gly Asp Ile His Ser Gly Lys Glu Trp Gly Lys His Ala Gly Val Pro 
            500                 505                 510         


Asp Phe Tyr Leu Ser Val Tyr Asp Ile Pro Ala Met Leu Phe Leu Thr 
        515                 520                 525             


Trp Leu Leu Gly Lys Asn Ser Ser Ala Val Glu Lys Leu Leu Ala Asn 
    530                 535                 540                 


Cys Lys Ala Ala Tyr Met Lys Leu Phe Asp Asp Leu Ala Lys Gly Lys 
545                 550                 555                 560 


Trp Glu Gly Glu Arg Asn Val Ser Asp Tyr Cys Ala Gly Glu Gly Thr 
                565                 570                 575     


Val Arg Tyr Thr Leu Arg Trp Tyr Asp Val Pro Met Lys Ile Arg Arg 
            580                 585                 590         


Lys Met Pro Leu Leu Gly Gly Asp Arg Asp Phe Glu Glu Lys Lys Ser 
        595                 600                 605             


Phe Glu Thr Leu Ala Gln Glu Ala Leu Thr Arg Met Leu Gln Arg Thr 
    610                 615                 620                 


Glu Asn Gln Leu Glu Lys Phe Asp Arg Asp Leu Ala Ala Ala Arg Asp 
625                 630                 635                 640 


Leu Lys Ala Asn Lys Gln Gly Lys Asp Arg Phe Val Asp Ile Arg Ala 
                645                 650                 655     


Gly Ser Leu Ala Thr Phe Leu Ala Arg Asp Ile Val Arg Leu Met Pro 
            660                 665                 670         


Val Ser Asp Asn Gly Arg Asn Lys Pro Thr Gly Leu Asn Tyr Ser Ile 
        675                 680                 685             


Val Gln Lys Ala Ile Ala Thr Tyr Lys Pro Ser Glu Gly Gly Leu Asp 
    690                 695                 700                 


Thr Leu Thr Gly Val Phe Arg Asp Ala Arg Ile Ile Gly Val Lys Gly 
705                 710                 715                 720 


Gly Ser His Pro Phe Leu Glu Arg Leu Leu Val Glu Lys Lys Pro Ser 
                725                 730                 735     


Ser Val Leu Ala Leu Tyr Arg His Tyr Leu Glu Tyr Arg Lys Glu Tyr 
            740                 745                 750         


Leu Lys Lys Ala Leu Glu Asp Glu Asn Lys Ala Glu Leu Lys Asn Leu 
        755                 760                 765             


Pro Phe Leu Lys Ser Gly Arg Gln Lys Tyr Ala Val Asp Gln Ala Asp 
    770                 775                 780                 


Tyr Ala Arg Arg Leu Ala Glu Ser Tyr Arg Asn Cys Pro Ile Tyr Leu 
785                 790                 795                 800 


Pro Thr Gly Ile Phe Thr Asp Met Leu Lys Asp Gln Leu Ala Lys Ile 
                805                 810                 815     


Asp Val Met Lys Pro Val Leu Glu Asn Asp Lys Val Asn Ala Ser Tyr 
            820                 825                 830         


Leu Ile Ala Gln Tyr Phe Glu Lys Val Glu His Asp Ser Glu Gln Pro 
        835                 840                 845             


Leu Tyr Arg Leu Lys Arg Asn Tyr Arg Val Phe Asp Leu Leu Glu Phe 
    850                 855                 860                 


Thr Asp Glu Pro Lys Tyr Trp Arg Leu Asn Glu Arg Ser Asp Lys Ala 
865                 870                 875                 880 


Gly Lys Tyr Gly Leu Ala Lys Arg Asn Ile Phe Trp Asn Arg Met Gly 
                885                 890                 895     


Glu Tyr Tyr Lys Gly Leu Lys Lys Phe Tyr Lys Gly Tyr Glu Ser Lys 
            900                 905                 910         


Arg Thr Ala Val Asp Trp Arg Glu Lys Leu Lys Ile Val Glu Ala Glu 
        915                 920                 925             


His Ala Met Trp Asn Arg Leu Lys Asp Ala Ser Gly Glu Ala Arg Leu 
    930                 935                 940                 


Lys Met Lys Asp Gly Val Phe Tyr Ser Arg Leu Leu Ser Ala Arg Lys 
945                 950                 955                 960 


Glu Tyr Asp Asp Cys Glu Arg Ala Leu Arg Arg Leu Lys Val Gln Asp 
                965                 970                 975     


Ile Val Leu Phe Leu Ala Ala Arg Glu Thr Leu Ile Leu Pro Lys Asp 
            980                 985                 990         


Lys Val Phe Arg Leu Lys Asn Leu  Ser Leu Ser Glu Gly  Asn Lys Asn 
        995                 1000                 1005             


Ile Leu  Ser Ser Ala Ile Asp  Glu Phe Ser Val Asp  Val Val Trp 
    1010                 1015                 1020             


Thr Glu  Lys Glu Gly Ala Ala  Lys Val Thr His Ser  Ala Ser Ile 
    1025                 1030                 1035             


Lys Glu  Asn Asp Val Val Ile  Lys Asn Tyr Gly Arg  Met Phe Arg 
    1040                 1045                 1050             


Leu Leu  His Asp Asp Arg Val  Lys Thr Leu Leu Pro  His Ile Tyr 
    1055                 1060                 1065             


Asp Ser  Ala Leu Ser Glu Asn  Ile Thr Gly Asp Arg  Ile Thr Val 
    1070                 1075                 1080             


Lys Asp  Asn Lys Val Ile Ile  Asp Lys Ser Leu Phe  Asp Glu Asp 
    1085                 1090                 1095             


Leu Met  Asn Tyr Asp Leu Arg  Arg His Glu Ile Cys  Glu Ile Ile 
    1100                 1105                 1110             


Leu Arg  Phe Glu Ala Ala Ser  Ile Lys Arg Phe Gly  Leu Asp Gly 
    1115                 1120                 1125             


Arg Val  Asp Phe Lys Ala Ala  Leu Asp Ala Leu Thr  Gly Arg Ser 
    1130                 1135                 1140             


Leu Leu  Asn Asp Glu Asp Ala  Arg Ile Leu Ser Ala  Ile Arg Asn 
    1145                 1150                 1155             


Ala Tyr  Asn His Asn Lys Tyr  Pro Ala Lys Gly Thr  Asp Val Lys 
    1160                 1165                 1170             


Val Asn  Val Met Ala Leu Pro  Lys Leu Thr Glu Asp  Leu Leu Arg 
    1175                 1180                 1185             


Ile Phe  Ser Asp Thr Gly Asn  Asn Arg Val Arg 
    1190                 1195                 


<210>  1329
<211>  1081
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1329

Met Gln Ala Gln Ser Leu Phe Asp Glu Tyr Lys His Leu Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Val Met Ser Ile Met Asn Ile Ile Thr Val Leu Asn His Ile 
            20                  25                  30          


His Gln Ile Ala Gly Leu Lys Arg Asn Glu Leu Gly Asp Asp Asp Asn 
        35                  40                  45              


Ile Tyr Ser His Pro Val Leu Lys Tyr Ile Ala Pro Glu Asn Asn Ser 
    50                  55                  60                  


Thr Thr Leu Pro Glu Lys Arg Asp Leu Ile Lys Glu Leu Leu Leu Glu 
65                  70                  75                  80  


Tyr Leu Pro Phe Leu Glu Ala Met Lys Asp Cys Tyr Lys Glu Val Lys 
                85                  90                  95      


Val Glu Lys Asp Lys Arg Asn Asn Lys Tyr Val Lys Asp Lys Lys Gln 
            100                 105                 110         


Val Phe Ile Arg Asn Tyr Ser Asp Ile Tyr Cys Ile Tyr Trp Thr Leu 
        115                 120                 125             


Tyr Asn Ile Phe Ser Thr Leu Ile Asn Tyr Arg Asp Lys Ser Cys His 
    130                 135                 140                 


Tyr Arg Phe Ile Pro Ser Lys Asp Gln Glu Glu Tyr Ser Lys Arg Thr 
145                 150                 155                 160 


Glu Tyr Asp Thr Val Arg Ile Ile Asn Lys Tyr Tyr Thr Tyr Ala Leu 
                165                 170                 175     


Arg Lys Thr Lys Glu Lys Tyr Gly Tyr Thr Thr Glu Gln Leu Ser Phe 
            180                 185                 190         


Ile Gln Asn Asn Arg Tyr Thr Asp Asp Lys Lys Val Asn Phe Asn Phe 
        195                 200                 205             


Phe Leu Ser Met Gln Ser Ser Asn Asn Asn Leu Ser His Val Gly Val 
    210                 215                 220                 


Ala Gln Leu Ile Cys Leu Phe Leu Gln Lys Lys Asp Val Asp Asn Phe 
225                 230                 235                 240 


Leu Glu Asn Leu Pro Ile Tyr Asp Asn Arg Tyr Cys Leu Gly Ile Asp 
                245                 250                 255     


Glu His Met Ile Ile Lys Arg Ser Leu Ala Leu His Ser Ile Lys Leu 
            260                 265                 270         


Pro Lys Glu Arg Leu Asn Ser Glu Lys Lys Asp Met Ala Ile Ala Met 
        275                 280                 285             


Asp Met Leu Asn Glu Leu Lys Arg Cys Pro Lys Glu Leu Phe Asn Thr 
    290                 295                 300                 


Leu Pro Phe Asp Lys Gln Glu Arg Phe Arg Ile Ile Ser Ser Asp His 
305                 310                 315                 320 


Lys Glu Val Leu Leu Met Arg Ser Thr Asp Arg Phe Val Pro Leu Ile 
                325                 330                 335     


Leu Gln Tyr Ile Asp Cys Asn Lys Lys Phe Lys Asp Ile Arg Phe His 
            340                 345                 350         


Val Asn Met Gly Lys Leu Arg Tyr Leu Phe Ser Pro Asn Lys Leu Cys 
        355                 360                 365             


Ile Asp Asn Gln Glu Arg Val Arg Met Leu Glu His Leu Leu Asn Gly 
    370                 375                 380                 


Tyr Gly Arg Ile Asp Glu Val Glu Tyr Leu Arg Lys Ala Pro Asn Gly 
385                 390                 395                 400 


Thr Phe Gly Asn Thr Asn Ile Pro Ile Lys Gly Phe Gly Glu Ile Glu 
                405                 410                 415     


Arg Asp Ser Ala Asp Ser Asn Asn Tyr Pro Tyr Ile Val Asp Thr His 
            420                 425                 430         


Thr His Tyr Ile Leu Asn Asn Asn Lys Val Glu Phe Cys Phe Cys Glu 
        435                 440                 445             


Asp Ser Lys Asn Lys Asn Val Phe Pro Thr Ile Glu Lys Glu Ile Asn 
    450                 455                 460                 


Gly Lys Trp Tyr Val Glu Lys Thr Ala Pro His Cys Arg Ile Ser Phe 
465                 470                 475                 480 


Phe Glu Ile Pro Ala Met Ala Phe His Met Phe Leu Cys Gly Ser Glu 
                485                 490                 495     


Lys Thr Glu Lys Leu Ile Lys Asp Val Tyr Asn Asn Tyr Ile Ser Leu 
            500                 505                 510         


Phe Asn Ala Leu Lys Asn Gly Ala Leu Thr Glu Glu Asn Tyr Lys Asp 
        515                 520                 525             


Phe Asn Ile Pro Glu Cys Asp Met Pro Lys Lys Ile Leu Asp Phe Leu 
    530                 535                 540                 


Lys Gly Lys Ala Glu Gly Lys Ser Ile Asp Gly Tyr Val Lys Asn Ile 
545                 550                 555                 560 


Leu Lys Lys Glu Leu Lys Asp Thr Arg Lys Arg Ile Glu Gln Ala Pro 
                565                 570                 575     


Ser Glu Lys Asp Gln Met Pro Ser Lys Arg Asn Lys Ile Gly Thr Lys 
            580                 585                 590         


Ser Tyr Lys Arg Val Leu Thr Gly Lys Leu Ala Asp Phe Leu Ala Lys 
        595                 600                 605             


Asp Ile Val Lys Tyr Gln Pro Thr Leu Cys Ala Gly Asp Asp Tyr Gly 
    610                 615                 620                 


Ile Asp Arg Met Thr Gly Met Asn Tyr Arg Ile Met Gln Ala Thr Ile 
625                 630                 635                 640 


Ala Thr Tyr Asn Asp Asp Asp Asp Phe Asp Thr Phe Tyr Asn Val Phe 
                645                 650                 655     


Lys Met Ala Gly Leu Val Asp Gly Asp Glu Arg Lys Asn His Pro Phe 
            660                 665                 670         


Leu Lys Lys Val Leu Leu Ser Lys Pro Gln Asn Thr Val Ala Phe Asn 
        675                 680                 685             


Ile Lys Tyr Leu Lys Glu Lys Glu Ile Tyr Leu Arg Asn Ile Glu Lys 
    690                 695                 700                 


Lys Asn Ile Ile Pro Pro Phe Val Asn Arg Glu Arg Asn Lys Trp Cys 
705                 710                 715                 720 


Glu Arg Asp Cys Glu Tyr Tyr Arg Ile Leu Gly Glu Asn Leu Leu Asp 
                725                 730                 735     


Leu Pro Ile Glu Leu Pro Arg Gln Met Phe Tyr Lys Asp Ile Arg Ala 
            740                 745                 750         


Gln Leu Glu Pro Leu Met Pro Glu Ile Asp Phe Ser Gln Thr Asn Thr 
        755                 760                 765             


Thr Tyr Leu Ile Ala Glu Tyr Leu Lys Arg Val Arg Gly Asp Asp Phe 
    770                 775                 780                 


Gln Glu Phe Tyr Ser Trp Glu Arg Asn Tyr Arg Tyr Ile Asp Phe Leu 
785                 790                 795                 800 


Lys Cys Ile Arg Asp Asp Asn Gly Arg Ile Cys Ala Gln Tyr Thr Thr 
                805                 810                 815     


Thr Glu Glu Arg Glu Ser Leu Trp Glu Asp Ser Lys Asn Arg Thr Ala 
            820                 825                 830         


Glu Tyr Lys Arg Ser Glu Glu Gln Lys Asn Glu Lys Lys Asp Lys Asn 
        835                 840                 845             


Phe Glu Asp Ser Leu Glu Glu Arg Ile Ser Ser Ser His Ile Lys Phe 
    850                 855                 860                 


Gln Asn Thr Glu Lys His Ile Arg Arg Tyr Lys Val Gln Asp Ala Leu 
865                 870                 875                 880 


Leu Phe Met Ile Ala Glu Lys Gln Phe Gly Lys Tyr Leu Asp Asp Ile 
                885                 890                 895     


Lys Ala Lys Asn Phe Lys Leu Lys Asp Ile Met Pro Asp Thr Asp Lys 
            900                 905                 910         


Gly Ile Leu Ser Glu Thr Met Pro Ile Asp Phe Thr Phe Thr Lys Lys 
        915                 920                 925             


Asn Ile Lys Tyr Asn Ile His Ala Lys Asn Leu Lys Phe Lys Glu Tyr 
    930                 935                 940                 


Gly Asp Leu Phe Ile Leu Ala Asn Asp Lys Arg Leu Glu Ser Leu Trp 
945                 950                 955                 960 


Lys Ile Leu Ala Thr Asp Thr Val Asn Lys Glu Glu Ile Ser Glu Glu 
                965                 970                 975     


Phe Ala Lys Tyr Asp Phe Cys Arg Pro Asp Ile Thr Lys Leu Val Leu 
            980                 985                 990         


Asp Phe Glu Lys Asp Val Leu Glu  Lys Tyr Pro Glu Ile  Ile Glu Glu 
        995                 1000                 1005             


Ala Glu  Lys Glu Tyr Lys Lys  Phe Asp Phe Lys Phe  Ile Leu Asp 
    1010                 1015                 1020             


Trp Leu  Ile Asn Lys Lys Lys  Leu Asn Tyr Gly Ile  Arg Asn Lys 
    1025                 1030                 1035             


Leu Leu  Leu Ile Arg Asn Ala  Phe Asn His Asn Ser  Tyr Pro Asp 
    1040                 1045                 1050             


Lys Lys  Tyr Ala Glu Val Arg  Glu Leu Pro Glu Ile  Ala Thr Asn 
    1055                 1060                 1065             


Leu Lys  Lys Thr Phe Asp Glu  Asn Ala Lys Lys Tyr  Glu 
    1070                 1075                 1080     


<210>  1330
<211>  1081
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1330

Met Gln Ala Gln Ser Leu Phe Asp Glu Tyr Lys His Leu Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Val Met Ser Ile Met Asn Ile Ile Thr Val Leu Asn His Ile 
            20                  25                  30          


His Gln Ile Ala Gly Leu Lys Arg Asn Glu Leu Gly Asp Asp Asp Asn 
        35                  40                  45              


Ile Tyr Ser His Pro Val Leu Lys Tyr Ile Ala Pro Glu Asn Asn Ser 
    50                  55                  60                  


Thr Thr Leu Pro Glu Lys Arg Asp Leu Ile Lys Glu Leu Leu Leu Glu 
65                  70                  75                  80  


Tyr Leu Pro Phe Leu Glu Ala Met Lys Asp Cys Tyr Lys Glu Val Lys 
                85                  90                  95      


Val Glu Lys Asp Lys Arg Asn Asn Lys Tyr Val Lys Asp Lys Lys Gln 
            100                 105                 110         


Val Phe Ile Arg Asn Tyr Ser Asp Ile Tyr Cys Ile Tyr Trp Thr Leu 
        115                 120                 125             


Tyr Asn Ile Phe Ser Thr Leu Ile Asn Tyr Arg Asp Lys Ser Cys His 
    130                 135                 140                 


Tyr Arg Phe Ile Pro Ser Lys Asp Gln Glu Glu Tyr Ser Lys Arg Thr 
145                 150                 155                 160 


Glu Tyr Asp Thr Val Arg Ile Ile Asn Lys Tyr Tyr Thr Tyr Ala Leu 
                165                 170                 175     


Arg Lys Thr Lys Glu Lys Tyr Gly Tyr Thr Thr Glu Gln Leu Ser Phe 
            180                 185                 190         


Ile Gln Asn Asn Arg Tyr Thr Asp Asp Lys Lys Val Asn Phe Asn Phe 
        195                 200                 205             


Phe Leu Ser Met Gln Ser Ser Asn Asn Asn Leu Ser His Val Gly Val 
    210                 215                 220                 


Ala Gln Leu Ile Cys Leu Phe Leu Gln Lys Lys Asp Val Asp Asn Phe 
225                 230                 235                 240 


Leu Glu Asn Leu Pro Ile Tyr Asp Asn Arg Tyr Cys Leu Gly Ile Asp 
                245                 250                 255     


Glu His Met Ile Ile Lys Arg Ser Leu Ala Leu His Ser Ile Lys Leu 
            260                 265                 270         


Pro Lys Glu Arg Leu Asn Ser Glu Lys Lys Asp Met Ala Ile Ala Met 
        275                 280                 285             


Asp Met Leu Asn Glu Leu Lys Arg Cys Pro Lys Glu Leu Phe Asn Thr 
    290                 295                 300                 


Leu Pro Phe Asp Lys Gln Glu Arg Phe Arg Ile Ile Ser Ser Asp His 
305                 310                 315                 320 


Lys Glu Val Leu Leu Met Arg Ser Thr Asp Arg Phe Val Pro Leu Ile 
                325                 330                 335     


Leu Gln Tyr Ile Asp Cys Asn Lys Lys Phe Lys Asp Ile Arg Phe His 
            340                 345                 350         


Val Asn Met Gly Lys Leu Arg Tyr Leu Phe Ser Pro Asn Lys Leu Cys 
        355                 360                 365             


Ile Asp Asn Gln Glu Arg Val Arg Met Leu Glu His Leu Leu Asn Gly 
    370                 375                 380                 


Tyr Gly Arg Ile Asp Glu Val Glu Tyr Leu Arg Lys Ala Pro Asn Gly 
385                 390                 395                 400 


Thr Phe Gly Asn Thr Asn Ile Pro Ile Lys Gly Phe Gly Glu Ile Glu 
                405                 410                 415     


Arg Asp Ser Ala Asp Ser Asn Asn Tyr Pro Tyr Ile Val Asp Thr His 
            420                 425                 430         


Thr His Tyr Ile Leu Asn Asn Asn Lys Val Glu Phe Cys Phe Cys Glu 
        435                 440                 445             


Asp Ser Lys Asn Lys Asn Val Phe Pro Thr Ile Glu Lys Glu Ile Asn 
    450                 455                 460                 


Gly Lys Trp Tyr Val Glu Lys Thr Ala Pro His Cys Arg Ile Ser Phe 
465                 470                 475                 480 


Phe Glu Ile Pro Ala Met Ala Phe His Met Phe Leu Cys Gly Ser Glu 
                485                 490                 495     


Lys Thr Glu Lys Leu Ile Lys Asp Val Tyr Asn Asn Tyr Ile Ser Leu 
            500                 505                 510         


Phe Asn Ala Leu Lys Asn Gly Ala Leu Thr Glu Glu Asn Tyr Lys Asp 
        515                 520                 525             


Phe Asn Ile Pro Glu Cys Asp Met Pro Lys Lys Ile Leu Asp Phe Leu 
    530                 535                 540                 


Lys Gly Lys Ala Glu Gly Lys Ser Ile Asp Gly Tyr Val Lys Asn Ile 
545                 550                 555                 560 


Leu Lys Lys Glu Leu Lys Asp Thr Arg Lys Arg Ile Glu Gln Ala Pro 
                565                 570                 575     


Ser Glu Lys Asp Gln Met Pro Ser Lys Arg Asn Lys Ile Gly Thr Lys 
            580                 585                 590         


Ser Tyr Lys Arg Val Leu Thr Gly Lys Leu Ala Asp Phe Leu Ala Lys 
        595                 600                 605             


Asp Ile Val Lys Tyr Gln Pro Thr Leu Cys Ala Gly Asp Asp Tyr Gly 
    610                 615                 620                 


Ile Asp Arg Met Thr Gly Met Asn Tyr Arg Ile Met Gln Ala Thr Ile 
625                 630                 635                 640 


Ala Thr Tyr Asn Asp Asp Asp Asp Phe Asp Thr Phe Tyr Asn Val Phe 
                645                 650                 655     


Lys Met Ala Gly Leu Val Asp Gly Asp Glu Arg Lys Asn His Pro Phe 
            660                 665                 670         


Leu Lys Lys Val Leu Leu Ser Lys Pro Gln Asn Thr Val Ala Phe Asn 
        675                 680                 685             


Ile Lys Tyr Leu Lys Glu Lys Glu Ile Tyr Leu Arg Asn Ile Glu Lys 
    690                 695                 700                 


Lys Asn Ile Ile Pro Pro Phe Val Asn Arg Glu Arg Asn Lys Trp Cys 
705                 710                 715                 720 


Glu Arg Asp Cys Glu Tyr Tyr Arg Ile Leu Gly Glu Asn Leu Leu Asp 
                725                 730                 735     


Leu Pro Ile Glu Leu Pro Arg Gln Met Phe Tyr Lys Asp Ile Arg Ala 
            740                 745                 750         


Gln Leu Glu Pro Leu Met Pro Glu Ile Asp Phe Ser Gln Thr Asn Thr 
        755                 760                 765             


Thr Tyr Leu Ile Ala Glu Tyr Leu Lys Arg Val Arg Gly Asp Asp Phe 
    770                 775                 780                 


Gln Glu Phe Tyr Ser Trp Glu Arg Asn Tyr Arg Tyr Ile Asp Phe Leu 
785                 790                 795                 800 


Lys Cys Ile Arg Asp Asp Asn Gly Arg Ile Cys Ala Gln Tyr Thr Thr 
                805                 810                 815     


Thr Glu Glu Arg Glu Ser Leu Trp Glu Asp Ser Lys Asn Arg Thr Ala 
            820                 825                 830         


Glu Tyr Lys Arg Ser Glu Glu Gln Lys Asn Glu Lys Lys Asp Lys Asn 
        835                 840                 845             


Phe Glu Asp Ser Leu Glu Glu Arg Ile Ser Ser Ser His Ile Lys Phe 
    850                 855                 860                 


Gln Asn Thr Glu Lys His Ile Arg Arg Tyr Lys Val Gln Asp Ala Leu 
865                 870                 875                 880 


Leu Phe Met Ile Ala Glu Lys Gln Phe Gly Lys Tyr Leu Asp Asp Ile 
                885                 890                 895     


Lys Ala Lys Asn Phe Lys Leu Lys Asp Ile Met Pro Asp Thr Asp Lys 
            900                 905                 910         


Gly Ile Leu Ser Glu Thr Met Pro Ile Asp Phe Thr Phe Thr Lys Lys 
        915                 920                 925             


Asn Ile Lys Tyr Asn Ile His Ala Lys Asn Leu Lys Phe Lys Glu Tyr 
    930                 935                 940                 


Gly Asp Leu Phe Ile Leu Ala Asn Asp Lys Arg Leu Glu Ser Leu Trp 
945                 950                 955                 960 


Lys Ile Leu Ala Thr Asp Thr Val Asn Lys Glu Glu Ile Ser Glu Glu 
                965                 970                 975     


Phe Ala Lys Tyr Asp Phe Cys Arg Pro Asp Ile Thr Lys Leu Val Leu 
            980                 985                 990         


Asp Phe Glu Lys Asp Val Leu Glu  Lys Tyr Pro Glu Ile  Ile Glu Glu 
        995                 1000                 1005             


Ala Glu  Lys Glu Tyr Lys Lys  Phe Asp Phe Lys Phe  Ile Leu Asp 
    1010                 1015                 1020             


Trp Leu  Ile Asn Lys Lys Lys  Leu Asn Tyr Gly Ile  Arg Asn Lys 
    1025                 1030                 1035             


Leu Leu  Leu Ile Arg Asn Ala  Phe Asn His Asn Ser  Tyr Pro Asp 
    1040                 1045                 1050             


Lys Lys  Tyr Ala Glu Val Arg  Glu Leu Pro Glu Ile  Ala Thr Asn 
    1055                 1060                 1065             


Leu Lys  Lys Thr Phe Asp Glu  Asn Ala Lys Lys Tyr  Glu 
    1070                 1075                 1080     


<210>  1331
<211>  1199
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1331

Met Asn Thr Phe Ile Asp Ser Phe Ile Arg Arg Val Gln Ile Gln Asn 
1               5                   10                  15      


Gln Asn Gln Ser Trp Pro Lys Arg Pro Lys Tyr Val Arg Pro Val Glu 
            20                  25                  30          


Asn Ile Arg Pro Asp Asp Leu Ala Phe Gln Ser His Phe Thr Ala Tyr 
        35                  40                  45              


Leu Asn Met Ala Arg Gln Asn Cys Cys Ile Ile Leu Gly His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Gly Phe Lys Ala Ser Ser Val Lys Asp Thr Thr Leu Thr 
65                  70                  75                  80  


Ser Ser Pro Leu Leu Gly Gln Asn Gly Leu Leu Ser Pro Lys Lys Glu 
                85                  90                  95      


Val Ser Asp Leu Ile Arg Gly Arg Leu Leu Ser Ala Phe Pro Met Leu 
            100                 105                 110         


Asp Pro Met Ile Arg Tyr Arg Lys Ala Val Asp Lys Glu Lys Asp Asp 
        115                 120                 125             


Tyr Ala Arg Ile Ile Ile Thr Ser Glu Asp Val Ser Glu Met Leu Arg 
    130                 135                 140                 


Asp Leu Leu Asp Val Leu Ser Tyr Tyr Arg Asp Met Ala Ser His Val 
145                 150                 155                 160 


Val Phe Asn Asp Asp Arg Ser Val Ser Ala Glu Phe Ala Ser Lys Glu 
                165                 170                 175     


Lys Lys Val Ala Glu Cys Leu Asn Tyr Met Met Thr Val Ser Leu Arg 
            180                 185                 190         


Ile Val Lys Asp Arg Phe Ser Leu Ala Val Ser Asp Leu Asp Phe Tyr 
        195                 200                 205             


Asn Arg Asn Arg Tyr Met Met Val Asn Arg Lys Pro Leu Leu Asn Ala 
    210                 215                 220                 


Gly Phe Ala His Ala Val Arg Thr Glu Asp Tyr Arg Leu Thr Leu Met 
225                 230                 235                 240 


Gly Leu Val Leu Leu Cys Cys Gln Phe Ile Glu Lys Gln Tyr Ala Ser 
                245                 250                 255     


Met Phe Phe Asp Ala Leu Asp Lys His Ser Asn Gly Ala Arg Phe Tyr 
            260                 265                 270         


Gly Ile Ala Asp Ala Met Pro Met Val Asn Val Gly Thr Lys Asp Lys 
        275                 280                 285             


Pro Lys Lys Ile Pro Met Tyr Thr Gly Asp Glu Ala Gln Lys Gln Val 
    290                 295                 300                 


Gln Lys Gln Arg Met Ala Leu Arg Glu Ala Tyr Ser Val Tyr Arg Val 
305                 310                 315                 320 


Arg Ile Pro Lys Glu Arg Leu Glu Ser Thr Arg Ser Asp Met Ala Leu 
                325                 330                 335     


Ala Leu Asp Ile Leu Asn Glu Leu Gly Lys Cys Pro Glu Glu Leu Phe 
            340                 345                 350         


Glu His Leu Ser Pro Glu Asp Arg Glu Ser Phe Lys Asn Glu Glu Gly 
        355                 360                 365             


Val Leu Met Lys Arg Tyr Ser Asp Arg Phe Pro Gln Leu Ala Leu Arg 
    370                 375                 380                 


Trp Leu Asp Glu Asn Glu Lys Phe Asn Asn Leu Arg Phe His Val Thr 
385                 390                 395                 400 


Phe Gly Lys Tyr Arg Trp Leu Phe Cys Gln Asp Lys Lys Cys Ala Asp 
                405                 410                 415     


Gly Ser Val Arg Pro Arg Trp Leu Gln Lys Glu Leu Asn Gly Phe Gly 
            420                 425                 430         


Arg Ile Gln Thr Val Glu Arg Lys Arg Thr Gly Leu Glu Pro Gly Trp 
        435                 440                 445             


Asp Gly Thr Gly Leu Ile Arg Lys Phe Glu Glu Val Val Thr Asp Glu 
    450                 455                 460                 


Val Gln Lys Glu Pro Tyr Ile Thr Asp Phe Arg Thr Gln Tyr Leu Phe 
465                 470                 475                 480 


Asn Arg Asp Lys Ile Gly Ile Ser Leu Ser Glu Tyr Met Pro Gly Ile 
                485                 490                 495     


Gly Asp Ile His Ser Gly Lys Glu Trp Gly Lys His Ala Gly Val Pro 
            500                 505                 510         


Asp Phe Tyr Leu Ser Val Tyr Asp Ile Pro Ala Met Leu Phe Leu Thr 
        515                 520                 525             


Trp Leu Leu Gly Lys Asn Ser Ser Ala Val Glu Lys Leu Leu Ala Asn 
    530                 535                 540                 


Cys Lys Ala Ala Tyr Met Lys Leu Phe Asp Asp Leu Ala Lys Gly Lys 
545                 550                 555                 560 


Trp Glu Gly Glu Arg Asn Val Ser Asp Tyr Cys Ala Gly Glu Gly Thr 
                565                 570                 575     


Val Arg Tyr Thr Leu Arg Trp Tyr Asp Val Pro Met Lys Ile Arg Arg 
            580                 585                 590         


Lys Met Pro Leu Leu Gly Gly Asp Arg Asp Phe Glu Glu Lys Lys Ser 
        595                 600                 605             


Phe Glu Thr Leu Ala Gln Glu Ala Leu Thr Arg Met Leu Gln Arg Thr 
    610                 615                 620                 


Glu Asn Gln Leu Glu Lys Phe Asp Arg Asp Leu Ala Ala Ala Arg Asp 
625                 630                 635                 640 


Leu Lys Ala Asn Lys Gln Gly Lys Asp Arg Phe Val Asp Ile Arg Ala 
                645                 650                 655     


Gly Ser Leu Ala Thr Phe Leu Ala Arg Asp Ile Val Arg Leu Met Pro 
            660                 665                 670         


Val Ser Asp Asn Gly Arg Asn Lys Pro Thr Gly Leu Asn Tyr Ser Ile 
        675                 680                 685             


Val Gln Lys Ala Ile Ala Thr Tyr Lys Pro Ser Glu Gly Gly Leu Asp 
    690                 695                 700                 


Thr Leu Thr Gly Val Phe Arg Asp Ala Arg Ile Ile Gly Val Lys Gly 
705                 710                 715                 720 


Gly Ser His Pro Phe Leu Glu Arg Leu Leu Val Glu Lys Lys Pro Ser 
                725                 730                 735     


Ser Val Leu Ala Leu Tyr Arg His Tyr Leu Glu Tyr Arg Lys Glu Tyr 
            740                 745                 750         


Leu Lys Lys Ala Leu Glu Asp Glu Asn Lys Ala Glu Leu Lys Asn Leu 
        755                 760                 765             


Pro Phe Leu Lys Ser Gly Arg Gln Lys Tyr Ala Val Asp Gln Ala Asp 
    770                 775                 780                 


Tyr Ala Arg Arg Leu Ala Glu Ser Tyr Arg Asn Cys Pro Ile Tyr Leu 
785                 790                 795                 800 


Pro Thr Gly Ile Phe Thr Asp Met Leu Lys Asp Gln Leu Ala Lys Ile 
                805                 810                 815     


Asp Val Met Lys Pro Val Leu Glu Asn Asp Lys Val Asn Ala Ser Tyr 
            820                 825                 830         


Leu Ile Ala Gln Tyr Phe Glu Lys Val Glu His Asp Ser Glu Gln Pro 
        835                 840                 845             


Leu Tyr Arg Leu Lys Arg Asn Tyr Arg Val Phe Asp Leu Leu Glu Phe 
    850                 855                 860                 


Thr Asp Glu Pro Lys Tyr Trp Arg Leu Asn Glu Arg Ser Asp Lys Ala 
865                 870                 875                 880 


Gly Lys Tyr Gly Leu Ala Lys Arg Asn Ile Phe Trp Asn Arg Met Gly 
                885                 890                 895     


Glu Tyr Tyr Lys Gly Leu Lys Lys Phe Tyr Lys Gly Tyr Glu Ser Lys 
            900                 905                 910         


Arg Thr Ala Val Asp Trp Arg Glu Lys Leu Lys Ile Val Glu Ala Glu 
        915                 920                 925             


His Ala Met Trp Asn Arg Leu Lys Asp Ala Ser Gly Glu Ala Arg Leu 
    930                 935                 940                 


Lys Met Lys Asp Gly Val Phe Tyr Ser Arg Leu Leu Ser Ala Arg Lys 
945                 950                 955                 960 


Glu Tyr Asp Asp Cys Glu Arg Ala Leu Arg Arg Leu Lys Val Gln Asp 
                965                 970                 975     


Ile Val Leu Phe Leu Ala Ala Arg Glu Thr Leu Ile Leu Pro Lys Asp 
            980                 985                 990         


Lys Val Phe Arg Leu Lys Asn Leu  Ser Leu Ser Glu Gly  Asn Lys Asn 
        995                 1000                 1005             


Ile Leu  Ser Ser Ala Ile Asp  Glu Phe Ser Val Asp  Val Val Trp 
    1010                 1015                 1020             


Thr Glu  Lys Glu Gly Ala Ala  Lys Val Thr His Ser  Ala Ser Ile 
    1025                 1030                 1035             


Lys Glu  Asn Asp Val Val Ile  Lys Asn Tyr Gly Arg  Met Phe Arg 
    1040                 1045                 1050             


Leu Leu  His Asp Asp Arg Val  Lys Thr Leu Leu Pro  His Ile Tyr 
    1055                 1060                 1065             


Asp Ser  Ala Leu Ser Glu Asn  Ile Thr Gly Asp Arg  Ile Thr Val 
    1070                 1075                 1080             


Lys Asp  Asn Lys Val Ile Ile  Asp Lys Ser Leu Phe  Asp Glu Asp 
    1085                 1090                 1095             


Leu Met  Asn Tyr Asp Leu Arg  Arg His Glu Ile Cys  Glu Ile Ile 
    1100                 1105                 1110             


Leu Arg  Phe Glu Ala Ala Ser  Ile Lys Arg Phe Gly  Leu Asp Gly 
    1115                 1120                 1125             


Arg Val  Asp Phe Lys Ala Ala  Leu Asp Ala Leu Thr  Gly Arg Ser 
    1130                 1135                 1140             


Leu Leu  Asn Asp Glu Asp Ala  Arg Ile Leu Ser Ala  Ile Arg Asn 
    1145                 1150                 1155             


Ala Tyr  Asn His Asn Lys Tyr  Pro Ala Lys Gly Thr  Asp Val Lys 
    1160                 1165                 1170             


Val Asn  Val Met Ala Leu Pro  Lys Leu Thr Glu Asp  Leu Leu Arg 
    1175                 1180                 1185             


Ile Phe  Ser Asp Thr Gly Asn  Asn Arg Val Arg 
    1190                 1195                 


<210>  1332
<211>  1254
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1332

Met Gly Asn Tyr Gln Gln Asn Trp Lys Lys Arg Arg Thr Gly Ser Gln 
1               5                   10                  15      


Pro Asn Ala Met Ser Asp Gln Leu Arg Pro Val Phe Ala Ala Tyr Leu 
            20                  25                  30          


Asn Met Ala Arg Ala Asn Leu Tyr Ser Val Leu Arg Tyr Ile Ser Val 
        35                  40                  45              


Gln Cys Gly Leu Glu Val Asn Gln Asn Glu Asp Ser Met His Glu Leu 
    50                  55                  60                  


Pro Ile Ala Lys Phe Ala Ser Asn Lys Arg Pro Glu Val Arg Gln Lys 
65                  70                  75                  80  


Ala Phe Leu Leu Leu Met Arg Asn Ile Pro Ile Leu Gln Gln Met Thr 
                85                  90                  95      


Gln Ser Gly Leu Thr Gln Gly Lys Pro Ala Asp Gly Asp Arg Pro Ala 
            100                 105                 110         


Lys Glu Lys His Leu Ala Val Glu Gln Glu Asp Leu Gln Arg Val Leu 
        115                 120                 125             


Gln Asn Leu Ile Arg Val Val Asn Phe Lys Arg Asn Leu Phe Thr His 
    130                 135                 140                 


Ala Asp His Tyr Asp Thr Asp Glu Glu Ile Glu Lys Glu Leu Gln Arg 
145                 150                 155                 160 


Glu Val Ala Leu Ser Gly Pro Leu Asn Thr Ala Phe Lys Gly Ser Lys 
                165                 170                 175     


Arg Glu Val Lys Arg Ile Phe Cys Tyr Thr Glu Lys Asp Met Asn Phe 
            180                 185                 190         


Val Asp Gln Asp Glu His Met Lys Arg Ile Pro Met Lys Asp Lys Asn 
        195                 200                 205             


Gly Asn Ile Met Gln Asp Glu Lys Gly Lys Asp Met Tyr Ile Phe Val 
    210                 215                 220                 


Glu Arg Ser Asn Trp Tyr Phe Arg Leu Tyr Asp Thr Thr Pro Asp Pro 
225                 230                 235                 240 


Val Thr Glu Met Pro Leu Ala Gln Lys Leu Thr Thr Val Gly Leu Val 
                245                 250                 255     


Phe Ile Leu Cys Lys Leu Leu His Lys Lys Tyr Ala Thr Gln Leu Val 
            260                 265                 270         


Gln Lys Thr Gly Leu Phe Arg Thr Arg Ala Gln Ser Gly Asn Ser Pro 
        275                 280                 285             


Phe Glu Lys Asn Glu Asn Glu Val Met Phe Asn Ile Phe Cys Ala His 
    290                 295                 300                 


Arg Ile Arg Leu Pro Lys Gly Arg Val Glu Ser Thr Val Ser Asn Tyr 
305                 310                 315                 320 


Ala Leu Gly Leu Asp Ile Leu Asn Glu Leu Gln Lys Cys Pro Ser Glu 
                325                 330                 335     


Leu Phe Glu Thr Leu Ser Pro Glu Asp Lys Glu Cys Phe Gln Val Lys 
            340                 345                 350         


Arg Lys Asp Asn Glu Thr Gln Pro Asp Pro Asp Asp Asp Val Asn Leu 
        355                 360                 365             


Phe Arg Arg Tyr Gly Asp Arg Phe Pro Tyr Leu Ala Met Arg Tyr Ile 
    370                 375                 380                 


Asp Ala Met Arg Gly Tyr Gln Asp Asp Tyr Lys Val Leu Glu Asp Ile 
385                 390                 395                 400 


Val Phe Gln Val Ser Leu Gly Lys Tyr Arg Phe Ser Phe Tyr Asn Arg 
                405                 410                 415     


Ala Ser Leu Asp Thr Thr Glu Lys Asp Arg Val Arg Val Leu Gln Lys 
            420                 425                 430         


Glu Ile Asn Gly Phe Gly Pro Ile Asp Lys Met Glu Gln Lys Arg Lys 
        435                 440                 445             


Glu Lys Tyr Lys Thr Ile Ile Arg Pro Ile Ser Asp Asp Pro Lys His 
    450                 455                 460                 


Leu Tyr Asp Ala Asp Thr Ala Glu Thr Gln Pro Tyr Leu Thr Asp Gln 
465                 470                 475                 480 


His Thr Ala Tyr Ala Ile Thr Gly Asn Arg Ile Gly Ile Thr Trp Asn 
                485                 490                 495     


Glu Arg Ile Gln Lys Pro Gln Ser Asn Glu Met Arg Ser Ser Ile Arg 
            500                 505                 510         


Leu Arg Trp Pro Glu Asn Glu Gln Asn Lys Val Ile Asn Ile Glu Lys 
        515                 520                 525             


Leu Asp Asn Asp Asn Cys Phe Leu Pro Asn Leu Pro Val Ser Thr Val 
    530                 535                 540                 


Asn Ile Ala Pro Arg Ala Trp Leu Ser Val His Asp Leu Pro Ala Leu 
545                 550                 555                 560 


Ile Phe Leu Arg Leu Leu Gly Gly Asp Pro Glu Ala Val Ile Lys Asp 
                565                 570                 575     


Thr Tyr Asn Arg Phe Val Leu Leu Leu Asn Ser Ile Lys Asn Gly Gln 
            580                 585                 590         


Leu Lys Pro Gln Asp Asn Lys Glu Lys Leu Leu Ala Ile Leu Ser Ala 
        595                 600                 605             


Glu Pro Tyr Lys Leu Arg Leu Ser Glu Ile Pro Lys Lys Leu Leu Asp 
    610                 615                 620                 


Tyr Leu Ser Ser Lys Gly Pro Lys Thr Gln Asp Glu Ala Asn Gln Ala 
625                 630                 635                 640 


Phe Thr Lys Trp Val Asn Lys Gln Leu Asp Gly Asp Val Gly Ile Ile 
                645                 650                 655     


Glu Lys Leu Arg Ile Arg Ile Glu Gln Phe Lys Gln Asp Leu Asn Val 
            660                 665                 670         


Val Gly Asp Lys Gln Asn Arg Ile Gly Arg Lys Gly Tyr Val Asp Ile 
        675                 680                 685             


Arg Pro Gly Ser Leu Ala Arg Tyr Ile Thr Lys Asp Ile Met Ala Met 
    690                 695                 700                 


Thr Arg Pro Asp Glu Ser Arg Lys Asn Asn Gly Lys Pro Ser Gly Leu 
705                 710                 715                 720 


Asp Phe Gly Val Leu Gln Ala Ala Ile Ala Thr Phe Lys Ala Asp Glu 
                725                 730                 735     


Ile Ala Leu Ala Lys Thr Ser Leu Gly Gly Met Ile Lys Ser Ala Ile 
            740                 745                 750         


Asn Val Asn Asn His Pro Phe Leu Asn Ser Val Leu Ser Gln Gln Val 
        755                 760                 765             


Thr Asp Thr Ile Asp Leu Tyr Ile Lys Tyr Gln Thr Ala Lys Leu Lys 
    770                 775                 780                 


Phe Phe Lys Ser Leu Arg Lys Gly Glu Lys Gly Asn Tyr Lys Asp Gln 
785                 790                 795                 800 


Trp Phe Leu Arg Glu Ala Tyr Arg Asn His Ala Ala Gln Thr Ser Glu 
                805                 810                 815     


Tyr Met Gln Gly Glu Lys Gly Leu Ala Ser Leu Tyr Leu Glu Thr Leu 
            820                 825                 830         


Gln Leu Pro Asp Gly Leu Phe Thr Asp Ala Ile His Lys Gln Leu Leu 
        835                 840                 845             


Asn Asn Glu Lys Thr Lys Asp Asn Val Glu Phe Leu Ala Ala Leu Ala 
    850                 855                 860                 


Asp Arg Glu Lys Thr Gly Gly Val Ser His Leu Ile Asn Leu Tyr Phe 
865                 870                 875                 880 


Glu Lys Val Ile Gly Asp Lys Pro Gln Ser Phe Tyr Arg Glu Met Lys 
                885                 890                 895     


Arg His Tyr Lys Val Ile Asp Trp Glu Met Phe Lys Tyr Asp Asp Glu 
            900                 905                 910         


His Pro Ile Leu Leu Thr Thr Ile Pro Pro Met Ile Tyr Ser Ser Pro 
        915                 920                 925             


Glu Lys Ile Ala Thr Leu Leu Arg Lys Gly Asp Ala Lys Glu Ser Pro 
    930                 935                 940                 


Ile Val Gln Asp Ile Asp Gln Ile Ser Asp Asn Ile Lys Arg Lys Ile 
945                 950                 955                 960 


Ser Lys Lys Trp Glu Ser Lys Pro Arg Tyr Ala Pro Ile Ser Arg Glu 
                965                 970                 975     


Glu Lys Leu Glu Leu Lys Ala Lys Leu Ile His Gln Met Arg Lys Leu 
            980                 985                 990         


Gln Gln Asn Glu Arg Asn Ile Arg  Arg Tyr Arg Asn Gln  Asp Met Leu 
        995                 1000                 1005             


Leu Phe  Glu Met Ala Lys Lys  Ile Leu Leu Ser Gly  Gly Ala Val 
    1010                 1015                 1020             


Ile Lys  Thr Asn Gly Gln Leu  Glu Arg Gly Ile Asp  Gln Phe Lys 
    1025                 1030                 1035             


Leu Gln  Asp Ile Leu Pro Pro  Ala Met Arg Gln Gly  Ser Asp Lys 
    1040                 1045                 1050             


Asp Leu  Leu Glu Gln Lys Val  Glu Phe Arg Leu Thr  Ile Asn Leu 
    1055                 1060                 1065             


Asn Asp  Glu Tyr Gly Lys Pro  Ile Lys Gly Ser Asp  Asp Lys Pro 
    1070                 1075                 1080             


Met Gln  Arg Thr Ile Ser Gln  Pro Glu Ile Lys Ile  Lys Asn Tyr 
    1085                 1090                 1095             


Gly Asp  Phe Tyr Thr Phe Leu  Tyr Asp Ser Arg Ile  Gly Thr Leu 
    1100                 1105                 1110             


Leu Ser  Gln Leu Thr Glu Asn  Gly Asp Ile Lys Arg  Asp Asp Leu 
    1115                 1120                 1125             


Glu Thr  Glu Phe Asp His Tyr  Asp Arg Gln Arg Gln  Glu Val Phe 
    1130                 1135                 1140             


Arg Leu  Leu Gln Lys Ile Glu  Arg Gln Ile Ile Lys  Ser His Pro 
    1145                 1150                 1155             


Ala Leu  Ala Asn Ser Asn Ala  Gly Lys Pro Gly Ser  Glu Phe Tyr 
    1160                 1165                 1170             


Asp Glu  Asn Gly Lys Pro Tyr  Arg Asn Ser Phe Ser  Ser Leu Leu 
    1175                 1180                 1185             


Leu Leu  Cys Lys Gln Tyr Leu  Ser Glu Gly Gly Glu  Pro Thr Asp 
    1190                 1195                 1200             


Val Ser  Asn Leu Leu Thr Glu  Ile Arg Asn Ala Phe  Ser His Asn 
    1205                 1210                 1215             


Arg Tyr  Val Lys Ser Gln Asp  Lys Gln Leu Asp Ile  Arg Thr Leu 
    1220                 1225                 1230             


Ser Leu  Pro Glu Val Ala Asp  His Ile Leu Asn Trp  Leu Arg Asn 
    1235                 1240                 1245             


His Gln  Tyr Lys Asn Glu 
    1250                 


<210>  1333
<211>  1251
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1333

Met Glu Glu Phe Asn Phe Lys Leu Lys Glu Thr Asp Tyr Thr Arg Leu 
1               5                   10                  15      


Tyr Ser Glu Gln Thr Asp Cys Lys Arg His Val Val Gly Ala Tyr Ala 
            20                  25                  30          


Asn Leu Ala Leu His Asn Met Thr Thr Val Val Asn Ser Ile Arg Gln 
        35                  40                  45              


Ala Val Gly Leu Asp Thr Ile Thr Asp Asp Thr Ile Lys Asp Ala Phe 
    50                  55                  60                  


Ser Arg Asp Ser Phe Lys Gly Leu Asp Ala Gly Asn Gln Leu Lys Leu 
65                  70                  75                  80  


Gln Asn Lys Leu Phe Arg His Phe Pro Phe Leu Arg Arg Met Lys Leu 
                85                  90                  95      


Glu Gln His Gly Thr Leu Asp Tyr Ser Lys Val Ile Asn Val Met Lys 
            100                 105                 110         


Asp Phe Ile Lys Leu Met Ser Ile Ile Arg Asp Asp Phe Ser His Tyr 
        115                 120                 125             


Cys Pro Tyr Ser Asn Lys Ser Gln Gln Thr Glu Asn Ser Ser Ile Lys 
    130                 135                 140                 


Lys Asn Ala Ser Lys Lys Leu Asp Glu Ile Phe Thr Asn Ser Val Ser 
145                 150                 155                 160 


Gln Asn Leu His Thr Ala Glu Glu Asn Glu Val Arg Asp Ser Val Gln 
                165                 170                 175     


Asn Ser Lys Thr Gln Gln Asp Lys Lys Ala Ser Thr Pro Leu Val Ser 
            180                 185                 190         


Ile Pro Met Arg Asp Asn Ala Gly Leu Thr Asp Ala Gly Ile Val Phe 
        195                 200                 205             


Phe Leu Cys Cys Phe Leu Glu Lys His Ser Ala Phe Glu Phe Leu Glu 
    210                 215                 220                 


Glu Ile Glu Phe Thr Glu Gly Leu Asn Pro Ala Asn Ala Leu Tyr Val 
225                 230                 235                 240 


Lys Glu Ile Leu Cys Met Asn Arg Ile Arg Met Thr Arg Ser Gln Ile 
                245                 250                 255     


Asp Ser Gln Met Ser Asp Thr Ala Leu Ala Leu Asp Met Met Asn Glu 
            260                 265                 270         


Leu Arg Lys Cys Pro Lys Pro Leu Tyr Asp Val Leu Asp Pro Ser Ser 
        275                 280                 285             


Arg Asn Tyr Phe Lys Asp Asp Ala Asn Leu Gln Trp Glu Glu Asp Asn 
    290                 295                 300                 


Pro Thr Gln Thr Asp Ser Gln Ser Pro Asp Ser His Asn Ile Thr Asp 
305                 310                 315                 320 


Leu Arg Ala Lys Ser Val Pro Arg Ser Thr Phe Val Arg Trp Gln Asn 
                325                 330                 335     


Arg Phe Pro Glu Met Ala Leu Cys Phe Ile Asp Leu Lys Arg Leu Phe 
            340                 345                 350         


Pro Thr Ile Arg Phe Gln Leu Arg Leu Gly Asn Tyr Arg Tyr Arg Phe 
        355                 360                 365             


Tyr Thr His Thr Ala Gln Gln Ser Leu Asp Gly Arg Glu Arg Leu Arg 
    370                 375                 380                 


Ile Leu Gln Lys Glu Leu His Gly Phe Gly Arg Ile Asp Glu Ile Glu 
385                 390                 395                 400 


Gln Thr Ile Lys Lys Glu Trp Gly Gln Tyr Ile Glu Lys Asn Thr Thr 
                405                 410                 415     


Asp Pro Lys Pro Lys Asp Gln Pro Asp Arg Thr Pro Tyr Ile Thr His 
            420                 425                 430         


Gln Arg Pro Gln Tyr Asn Ile Asn Pro Val Ser His Ser Ile Gly Leu 
        435                 440                 445             


Cys Trp Asp Phe Pro Asp Glu Lys Thr Tyr Tyr Ile Pro Glu Phe Pro 
    450                 455                 460                 


Pro Lys Lys Gln Asp Asp His Thr Gln Gln Gln Lys Cys Pro Ser Glu 
465                 470                 475                 480 


Asn Leu Ala Pro Gln Cys Tyr Leu Asn Thr Asp Glu Leu Pro Ala Leu 
                485                 490                 495     


Leu Phe Tyr Gln Tyr Ile Arg Asp Lys Tyr Arg Pro Asp Glu Asp Ser 
            500                 505                 510         


Ser Ala Glu Asn Ile Ile Trp Lys Cys Tyr Ser Asn Leu His Thr Leu 
        515                 520                 525             


Phe Ser Gln Leu Ala Asp Asn Lys Ala Ile Ser Ile Asn Glu Leu Asn 
    530                 535                 540                 


Lys Trp Glu Leu Arg Pro Ser Asp Ile Pro Ala Lys Ile Arg Lys Leu 
545                 550                 555                 560 


Met Glu Gly His Glu Arg Ser Glu Lys Glu Ile Arg Val Ser Leu Arg 
                565                 570                 575     


Arg Ser Ile Glu His Gln Leu Thr Leu Ile Lys Lys Thr Thr Lys Thr 
            580                 585                 590         


Arg Ile Ala Lys Tyr Lys Ala Ala Thr Asp Lys Glu Lys Gln Thr Asp 
        595                 600                 605             


Gln Lys Thr Thr Arg Phe Arg Pro Pro Ile Leu Thr Gly Arg Leu Ala 
    610                 615                 620                 


Gln Gln Leu Ile Asp Asp Ile Val Trp Trp Leu Pro Thr Asp Ser Pro 
625                 630                 635                 640 


Cys Arg Ser Arg Leu Thr Ser Glu Lys Tyr Asn Ile Leu Gln Ala Ser 
                645                 650                 655     


Ile Ala Leu Leu Gly Gln Trp Thr Ala Pro Ser Asp Pro Ser Gln Gln 
            660                 665                 670         


Thr Val Thr Ile Asp Asp Leu Gln Gln Met Met Glu Arg Ile Gly Leu 
        675                 680                 685             


Leu Gly Pro Asp Gly His Pro Phe Leu Ser Gln Val Phe Lys Gln Pro 
    690                 695                 700                 


Asn Gln Ser Ala Gly Ile Phe Tyr His Asn Tyr Leu Ser Ala Glu Gln 
705                 710                 715                 720 


Asp His Ile Glu Thr Leu Trp Gln Asp Phe Asp Leu Asn Leu Asp Gln 
                725                 730                 735     


Leu Ile Ser Gln Ala His Ala Lys Leu Pro Phe Val His Ile Asp Arg 
            740                 745                 750         


Pro Lys Trp Asn Val Asp Lys Ser Asn Asn Leu Pro Gln Leu Ala Gln 
        755                 760                 765             


Glu Tyr Leu Thr His Pro Leu Gln Leu Pro Leu Gly Leu Phe Ala Gln 
    770                 775                 780                 


Pro Ile Ala Gln Leu Leu Arg Asp Ile Ala Lys Gly Glu Ala Thr Glu 
785                 790                 795                 800 


Thr Trp Lys Gln Leu Thr Ala Glu Ile Asp Arg Leu Thr Gln Lys Gly 
                805                 810                 815     


Gln Pro Ser Thr Leu Lys Leu Ile Glu Leu Tyr His Lys Asn Ile Glu 
            820                 825                 830         


Glu Asp Asp Phe Gln Asn Phe Tyr Asn Ser Ser Pro Asn Ala Gly Phe 
        835                 840                 845             


Gln His His Tyr Glu Leu Phe Lys Lys Leu Tyr Asn Glu Lys Gly Arg 
    850                 855                 860                 


Ser Val Glu Glu Val Phe Asn Leu Leu Arg Gly Lys Asp Lys Ser Glu 
865                 870                 875                 880 


Glu Trp Ala Glu Asp Gln Thr Ala Leu Met Arg Lys Gln Ala Lys Gln 
                885                 890                 895     


Val Glu Gln Thr Glu His Ala Ile Arg Arg Cys Gln Ile Glu Asp Ile 
            900                 905                 910         


Val Met Leu Tyr Ala Ala Arg Asn Ile Leu Ser Pro Lys Asn Asp Gln 
        915                 920                 925             


Thr Pro Asn Gly Thr Asp Thr Ser Gln Pro Gln Lys Tyr Lys Leu Lys 
    930                 935                 940                 


His Val Gln Lys Asp Asp Glu Leu Leu Glu Arg Thr Ile Asp Phe Asp 
945                 950                 955                 960 


Trp Val Val Asp Ile Glu Gly Gln Gln Lys Thr Ile Arg Gln Gln Asn 
                965                 970                 975     


Met Lys Met Lys Asp Tyr Gly Lys Phe Tyr Lys Phe Ala Ser Asp Gly 
            980                 985                 990         


Glu Arg Leu Glu Ser Leu Leu Ala  His Leu Gly Gly Asn  Glu Phe Gln 
        995                 1000                 1005             


Arg Ala  Asp Ile Glu Ala Glu  Tyr Ala Asn Tyr Asp  Val Ser Arg 
    1010                 1015                 1020             


Ser Gln  Val Phe Arg Tyr Val  Tyr Met Leu Glu Ser  Lys Ala Tyr 
    1025                 1030                 1035             


Gln Leu  Leu Ala Lys Arg Lys  Asp Asn Pro Ile Asp  Leu Leu Asp 
    1040                 1045                 1050             


Asp Lys  Asn Ser Thr Arg Asp  Ala Phe Trp Phe Val  Ser Lys Glu 
    1055                 1060                 1065             


Gly Ile  Arg Asn Gly Phe Arg  Gly Phe Lys Glu Asn  Leu Phe Asn 
    1070                 1075                 1080             


Glu Tyr  Lys Ala Asn Asp Pro  Asp Ala Lys Ala Leu  Val Asp Ala 
    1085                 1090                 1095             


Ile Cys  Asn Phe Thr Gly Thr  Ser Ile Glu Glu Trp  Asp Ala Asn 
    1100                 1105                 1110             


Gln Asp  Thr Leu Met Lys Gln  Val Lys Ser Leu Leu  Thr Asn Glu 
    1115                 1120                 1125             


Asn Pro  Asn Glu Lys Asp Lys  Ala Leu Ile Leu Gln  Val Lys Asp 
    1130                 1135                 1140             


Tyr Cys  Met Lys Lys Lys Ile  Ala Arg Lys Ala Ile  Arg Asn Asn 
    1145                 1150                 1155             


Phe Gly  Glu Leu Ile Glu Ile  Leu Leu Arg Gly Asp  Glu Pro Ile 
    1160                 1165                 1170             


Phe Thr  Asp Asp Asp Lys Tyr  Ile Ile Gln His Ile  Arg Asn Ala 
    1175                 1180                 1185             


Phe Gly  His Asn His Tyr Leu  Lys Lys Glu Asp Glu  Tyr Asn Thr 
    1190                 1195                 1200             


Val Phe  Arg Gly Lys Glu Ala  Lys Leu Lys Leu Pro  Glu Val Ala 
    1205                 1210                 1215             


Lys Thr  Ile Lys Asp Trp Met  Gly Glu Lys Thr Thr  Lys Ala Leu 
    1220                 1225                 1230             


Ser Leu  Thr Pro Asp Thr Gln  Arg Ala Leu Pro Pro  Lys Ser Gln 
    1235                 1240                 1245             


Ala Ala  Glu 
    1250     


<210>  1334
<211>  1400
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1334

Met Pro Val Trp Gly Ala Thr Pro Ser Thr Pro Ser Tyr Ser His Phe 
1               5                   10                  15      


Cys Arg Cys Arg Ser His Pro Gln Tyr Pro Met Phe Cys Pro Ala Ala 
            20                  25                  30          


Lys Cys Arg Arg His Pro Pro Pro His Ala Val Arg Arg Lys Pro His 
        35                  40                  45              


Ser Gly Pro Pro Leu Ala Ile Glu Tyr His Ser Leu His Ser Leu Gln 
    50                  55                  60                  


Val Asn Asn Val Gln Pro Thr Pro Asn Ser Ile Ser Leu Lys Lys Lys 
65                  70                  75                  80  


Asn Leu His Pro Met Gly Leu Ile Cys Ile Phe Ala Asn Pro Lys Pro 
                85                  90                  95      


Ile Leu Tyr Pro Asn Arg Lys Thr Arg Lys Ser Ile Arg Met Asp Asn 
            100                 105                 110         


Gln Gln Ser Arg Asn Thr Asp Gly Gly Gln Pro Tyr Gly Lys Thr Gln 
        115                 120                 125             


Ala Arg Arg Lys Glu Arg Arg Ile Gln Ser Thr Asp Phe Ser Ile Gly 
    130                 135                 140                 


Leu Thr Gly Lys His Ile Phe Gly Ala Tyr Phe Asn Met Ala Arg Thr 
145                 150                 155                 160 


Asn Phe Glu Lys Thr Leu Tyr Tyr Ile Leu Pro Ile Val Gly Ile Arg 
                165                 170                 175     


Gly Lys Tyr Lys Glu Ser Asp Ile Asp Lys Met Leu His Ala Leu Tyr 
            180                 185                 190         


Leu Ile His Ser Gly Gln Ser Asp Lys Leu Thr Gly Glu Gln Lys Gly 
        195                 200                 205             


Trp Lys Lys Lys Leu Thr Leu Thr Val Glu Gln Gln Thr Arg Leu Gln 
    210                 215                 220                 


Arg Leu Leu Phe Lys His Phe Pro Val Leu Asn Pro Ile Met Ala Asp 
225                 230                 235                 240 


Thr Ala Asn Tyr Arg Ala Tyr Leu Glu Leu Asn Lys Lys Lys Ser Ser 
                245                 250                 255     


Val Gln Ser Glu Asp Glu Thr Phe Glu Gln Leu Lys Gly Ile Ser Leu 
            260                 265                 270         


Ala Asp Cys Leu Glu Leu Phe Ser Leu Ile Ser Asp Thr Leu Thr Glu 
        275                 280                 285             


Cys Arg Asn Phe Tyr Thr His Gln Asp Pro Tyr Asn Glu Pro Val Ala 
    290                 295                 300                 


Leu Glu Glu Gln Tyr Lys His Gln Ser Leu Ile Ala Ile Lys Leu Asn 
305                 310                 315                 320 


Lys Val Ile Glu Ala Ser Arg Arg Val Leu Lys Asp Arg Glu Gly Leu 
                325                 330                 335     


Thr Thr Gly Glu Val Glu Phe Leu Thr Gly Ile Asp His Arg Ile Gln 
            340                 345                 350         


Val Asp Lys Lys Asp Glu Asn Gly Asn Thr Ile Thr Glu Asn Gly Arg 
        355                 360                 365             


Ile Gln Lys Ala Phe Val Glu Tyr Asp Asp Phe Tyr Phe Lys Val Ser 
    370                 375                 380                 


Gly Thr Arg Thr Ile Gly Leu Ala Ser Tyr Pro Ala Leu Ser Asp Phe 
385                 390                 395                 400 


Gly Leu Leu Tyr Phe Cys Val Leu Phe Leu Ser Lys His Tyr Ala Lys 
                405                 410                 415     


Leu Leu Ile Asp Glu Ser Arg Leu Phe Glu Phe Ser Pro Phe Asn Glu 
            420                 425                 430         


Asn Glu Asn Phe Ile Leu Gln Glu Met Leu Ser Ile Tyr Arg Ile Arg 
        435                 440                 445             


Thr Pro Gln Pro His Arg Ile Asp Ser His Asp Asp Lys Ala Thr Leu 
    450                 455                 460                 


Ala Met Asp Ile Phe Ser Glu Leu Arg Arg Cys Pro Ile Glu Leu Tyr 
465                 470                 475                 480 


Asn Leu Leu Asp Lys Asp His Gly Gln Pro Phe Phe His Asp Glu Val 
                485                 490                 495     


Lys Arg Pro Asn Ser Phe Thr Pro Glu Val Ser Lys Arg Leu Arg Phe 
            500                 505                 510         


Asn Asp Arg Phe Pro His Leu Ala Leu Arg Tyr Ile Asp Met Ala Glu 
        515                 520                 525             


Leu Phe Gln Arg Ile Arg Phe Gln Leu Gln Leu Gly Ser Phe Arg Tyr 
    530                 535                 540                 


Lys Phe Tyr Asp Lys Leu Cys Thr Asp Gly Gln Thr Arg Val Arg Arg 
545                 550                 555                 560 


Ile Gln Lys Asp Ile Asn Gly Tyr Gly Arg Leu Gln Glu Val Asp Asp 
                565                 570                 575     


Lys Arg Trp Glu Arg Trp Gly Asp Leu Ile Gln Lys Ala Glu Glu His 
            580                 585                 590         


Pro Val Lys Leu Glu His Glu Glu Leu Tyr Leu Asp Leu Asp Gln Phe 
        595                 600                 605             


Val Gln Asp Thr Ala Glu Ser Thr Pro Tyr Ile Thr Asp Arg Arg Pro 
    610                 615                 620                 


Ser Tyr Asn Ile His Ala Asn Arg Ile Gly Leu Phe Trp Glu Glu Ser 
625                 630                 635                 640 


Lys Asp Thr Arg Gly Phe Lys Tyr Phe Asp Lys Asp Lys Val Tyr Ile 
                645                 650                 655     


Pro Glu Leu Thr Ile Thr Asn Asp Gly Lys Ala Ser Ile Lys Met Pro 
            660                 665                 670         


Pro Pro Arg Cys Thr Leu Ser Val His Asp Leu Pro Ala Leu Leu Phe 
        675                 680                 685             


Tyr Glu Tyr Leu Arg Ser Gln Thr Asp Ala Glu Tyr Lys Ser Ala Glu 
    690                 695                 700                 


Lys Ile Ile Ile Asp Thr Glu Ala Ala Tyr Arg Lys Phe Phe Ser Ala 
705                 710                 715                 720 


Val Ser Lys Gly Glu Ile Lys Pro Phe Glu Ser Pro Asp Ala Phe Asp 
                725                 730                 735     


Asp Phe Leu Arg Asp Tyr Tyr Pro Gln Ile Leu Tyr Asn Asp Ile Pro 
            740                 745                 750         


Glu Lys Ile Arg Leu Tyr Leu Ser Ser Leu Glu Pro Thr His Asn Gly 
        755                 760                 765             


Lys Pro Glu Thr Met Arg Gln Arg Leu Val Arg Leu Ala Leu Asp Gln 
    770                 775                 780                 


Leu Thr Gln Arg Gln Gln Gln Val Met Leu Arg Leu Lys His Phe Asn 
785                 790                 795                 800 


Asp Asn Ala Lys Arg Ile Gly Thr Lys Asp Asn Lys Leu Gly Lys Lys 
                805                 810                 815     


Gly Phe Ala Asp Ile Arg His Gly Val Leu Ala Arg Tyr Leu Val Gln 
            820                 825                 830         


Asp Met Met Glu Trp Gln Pro Thr Lys Asp Gly Glu Gly His Asp Lys 
        835                 840                 845             


Leu Thr Ser Leu Asn His Asn Val Leu Thr Ala Phe Leu Ala Thr Tyr 
    850                 855                 860                 


Gly Thr Pro Gln Ala Ser Leu Ala Asp Ser Asp Thr Pro Lys Leu Thr 
865                 870                 875                 880 


Leu His Glu Val Leu Gln Lys Ala Cys Leu Val Gly Gly Asn Asn Pro 
                885                 890                 895     


His Pro Phe Leu Asn Lys Val Leu Thr Tyr Asn Cys Arg Asn Ile Glu 
            900                 905                 910         


Glu Phe Tyr Lys Asn Tyr Leu Thr Ala Glu Glu Ser His Leu Gln Lys 
        915                 920                 925             


Tyr Ile Asn Thr Leu Arg Asn Asp Pro Ser Asp Gln Ala Leu Glu Ala 
    930                 935                 940                 


Leu Pro Phe Ile His His Thr Arg Ala Arg Phe Arg Glu Arg Asp Gln 
945                 950                 955                 960 


Ala Glu Ile Gln Ala Leu Ala Ala Arg Tyr Thr Thr Ile Gln Leu Pro 
                965                 970                 975     


Asp Gly Leu Phe Ala Ser Lys Ile Phe Asn Leu Leu Lys Glu Gln Tyr 
            980                 985                 990         


Thr Asp Asn Pro Asp Leu Gln Gln  Ala Leu Asn Phe Asp  Gly Pro Asp 
        995                 1000                 1005             


His Leu  Asn Pro Thr Tyr Asn  Ala Thr Tyr Leu Ile  Ala Gln Phe 
    1010                 1015                 1020             


Tyr Arg  His Glu Leu Lys Asp  Thr Ser Gln Pro Phe  Tyr Asn Thr 
    1025                 1030                 1035             


Asp Gln  Gln His Thr Thr Gln  Arg Gln Gly Gln Ala  Pro Glu Thr 
    1040                 1045                 1050             


Phe Asp  Phe Arg Arg Ala Tyr  Asp Leu Phe Ala Glu  Leu Asn Asn 
    1055                 1060                 1065             


Glu Lys  Pro Leu Phe Leu Thr  Ser Asp Gln Ile Gln  Ser Arg Leu 
    1070                 1075                 1080             


Thr Thr  Lys Arg Leu Asp Lys  Ser Gly Lys Pro Leu  Pro Gln Arg 
    1085                 1090                 1095             


Asp Ser  Asn Gly Lys Pro Gln  Arg Asp Pro Gln Gly  Asn Ile Ile 
    1100                 1105                 1110             


Tyr Gln  Arg Lys Ile Met Arg  Glu Ile Asp Lys Tyr  Val Asp Asp 
    1115                 1120                 1125             


Leu Ser  Ala Arg Asp Phe Lys  Cys Lys Gln Phe Glu  Val Pro Glu 
    1130                 1135                 1140             


Arg Arg  Glu Ala Lys Arg Glu  Lys Leu Lys Arg Met  Val Asn Glu 
    1145                 1150                 1155             


Thr Lys  Asn Thr Glu Arg Thr  Leu Arg Arg Tyr Arg  Thr Gln Asp 
    1160                 1165                 1170             


Met Val  Leu Phe Leu Leu Ala  Lys Gln Met Phe Ile  Lys Leu Leu 
    1175                 1180                 1185             


Asn Ala  Gln Asp Thr Pro Val  Asp Ala Glu Leu Met  Cys Leu Ser 
    1190                 1195                 1200             


Lys Val  Cys Asn Asp Asn Phe  Leu Arg Gln Ala Leu  Thr Phe Arg 
    1205                 1210                 1215             


Val Pro  Ile Thr Val Gly Asp  Gln Lys Val Ile Tyr  Val Glu Gln 
    1220                 1225                 1230             


Gly Asn  Met Ser Leu Val Asn  Tyr Gly Glu Phe Phe  Arg Leu Leu 
    1235                 1240                 1245             


Thr Asp  Glu Arg Leu Pro Thr  Leu Leu Lys Asn Ile  Val Asp Asp 
    1250                 1255                 1260             


Leu Val  Pro Asp Ala Gln Gly  Asp Leu Val Ile Ser  Tyr Asn Asn 
    1265                 1270                 1275             


Leu Trp  Ser Glu Leu Ala Ala  Tyr Asp Arg Gln Arg  Ser Thr Ala 
    1280                 1285                 1290             


Phe Gln  Leu Ile Gln Gln Ile  Glu Ala Leu Ala Leu  Lys Ser Asn 
    1295                 1300                 1305             


Ala Asn  Leu Tyr Asn Pro Asp  Ser Thr Glu Phe Trp  Gly Lys Gly 
    1310                 1315                 1320             


Asn Asn  Gly Pro Phe Ala Lys  Arg Asn Ser Phe Ser  Ala Leu Ile 
    1325                 1330                 1335             


Ala Leu  Ile Asp Arg Ile Asn  Thr Thr Gln Leu Thr  Asp Asp Glu 
    1340                 1345                 1350             


Arg Arg  Leu Leu Ile Ala Ile  Arg Asn Ser Phe Ala  His Asn Ser 
    1355                 1360                 1365             


Tyr Asp  Leu Asp Leu Lys Gln  Ile Asp Gly Ile Lys  Lys Leu Pro 
    1370                 1375                 1380             


Glu Val  Ala Lys Ser Ile Leu  Glu His Leu Lys Ser  Val Val Gly 
    1385                 1390                 1395             


Lys Gly  
    1400 


<210>  1335
<211>  1175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1335

Met Thr Glu Gln Asn Glu Arg Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Thr His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Asn Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro Arg Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Tyr Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Glu Lys Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Ala Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Asp Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Phe Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Asp Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Gly Glu Ile Asp Thr Arg Asp 
    530                 535                 540                 


Glu Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Ser Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Leu Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asn Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Glu Arg Ile Lys Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Asp Leu Glu Ala Trp Ser His Gly Ala Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Val Gly Ile Glu Tyr Ala Ser Pro Gly Asn 
    850                 855                 860                 


Lys Lys Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Glu Thr 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Lys Ala Asp Lys Ile Asn Ile Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Ala Lys Glu His Pro Tyr Leu Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asp Ile Arg Thr 
945                 950                 955                 960 


Asp Val His Glu Gln Gly Ser Leu Asn Val Leu Asn Arg Val Lys Pro 
                965                 970                 975     


Met Arg Leu Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val 
            980                 985                 990         


His Lys Glu Gln Ala Pro Leu Ala  Thr Val Tyr Ile Glu  Glu Arg Asp 
        995                 1000                 1005             


Thr Lys  Leu Leu Lys Gln Gly  Asn Phe Lys Ser Phe  Val Lys Asp 
    1010                 1015                 1020             


Arg Arg  Leu Asn Gly Leu Phe  Ser Phe Val Asp Thr  Gly Ala Leu 
    1025                 1030                 1035             


Ala Met  Glu Gln Tyr Pro Ile  Ser Lys Leu Arg Val  Glu Tyr Glu 
    1040                 1045                 1050             


Leu Ala  Lys Tyr Gln Thr Ala  Arg Val Cys Ala Phe  Glu Gln Thr 
    1055                 1060                 1065             


Leu Gly  Leu Glu Glu Ser Leu  Leu Thr Arg Tyr Pro  His Leu Pro 
    1070                 1075                 1080             


Asp Lys  Asn Phe Arg Lys Met  Leu Glu Ser Trp Ser  Asp Pro Leu 
    1085                 1090                 1095             


Leu Asp  Lys Trp Pro Asp Leu  His Gly Asn Val Arg  Leu Leu Ile 
    1100                 1105                 1110             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1115                 1120                 1125             


Glu Thr  Leu Phe Ser Ser Ile  Arg Lys Tyr Asp Pro  Ser Ser Pro 
    1130                 1135                 1140             


Asp Ala  Ile Glu Glu Arg Met  Gly Leu Asn Ile Ala  His Arg Leu 
    1145                 1150                 1155             


Ser Glu  Glu Val Lys Gln Ala  Lys Glu Met Val Glu  Arg Ile Ile 
    1160                 1165                 1170             


Gln Ala  
    1175 


<210>  1336
<211>  1119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1336

Met Glu Asp Asp Lys Lys Thr Thr Gly Ser Ile Ser Tyr Glu Leu Lys 
1               5                   10                  15      


Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val 
            20                  25                  30          


Tyr Ile Thr Ile Asn His Ile Asn Lys Leu Leu Glu Ile Arg Glu Ile 
        35                  40                  45              


Asp Asn Asp Glu Lys Val Leu Asp Ile Lys Ala Leu Trp Glu Lys Val 
    50                  55                  60                  


Asn Gly Asp Leu Asn Lys Thr Glu Arg Leu Arg Glu Leu Met Thr Lys 
65                  70                  75                  80  


His Phe Pro Phe Leu Glu Thr Ala Ile Tyr Thr Lys Asn Lys Glu Asp 
                85                  90                  95      


Lys Lys Glu Val Lys Gln Glu Lys Gln Ala Glu Ala Gln Ser Leu Glu 
            100                 105                 110         


Ser Leu Lys Asp Cys Leu Phe Leu Phe Leu Glu Lys Leu Gln Glu Ala 
        115                 120                 125             


Arg Asn Tyr Tyr Ser His Tyr Lys Tyr Ser Glu Phe Ser Lys Glu Pro 
    130                 135                 140                 


Glu Phe Glu Glu Gly Leu Leu Glu Lys Met Tyr Asn Ile Phe Asp Asp 
145                 150                 155                 160 


Asn Ile Gln Leu Val Ile Lys Asp Tyr Gln His Asn Lys Asp Ile Asn 
                165                 170                 175     


Pro Asp Glu Asp Phe Lys His Leu Asp Arg Lys Gly Gln Phe Lys Tyr 
            180                 185                 190         


Ser Phe Ala Asp Asn Glu Gly Asn Ile Thr Glu Ser Gly Leu Leu Phe 
        195                 200                 205             


Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Met Gln Gln 
    210                 215                 220                 


Lys Leu Arg Gly Phe Lys Asp Asn Arg Glu Ser Lys Lys Lys Met Thr 
225                 230                 235                 240 


His Glu Val Phe Cys Arg Ser Arg Met Leu Leu Pro Lys Leu Arg Leu 
                245                 250                 255     


Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu Asn Glu 
            260                 265                 270         


Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Gln Gly Lys Tyr 
        275                 280                 285             


Arg Lys Lys Phe Asn Ile Pro Phe Asp Pro Ala Asp Glu Asp Tyr Asp 
    290                 295                 300                 


Ala Glu Gln Glu Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg 
305                 310                 315                 320 


Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Tyr Asn Glu Ile Phe Thr 
                325                 330                 335     


Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile Tyr 
            340                 345                 350         


Lys Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg His Leu Thr His Lys 
        355                 360                 365             


Leu Tyr Gly Phe Glu Arg Ile Gln Glu Phe Ala Lys Gln Asn Arg Pro 
    370                 375                 380                 


Asp Glu Trp Lys Ala Ile Val Lys Asp Leu Asp Thr Tyr Glu Thr Ser 
385                 390                 395                 400 


Asn Glu Arg Tyr Ile Ser Glu Thr Thr Pro His Tyr His Leu Glu Asn 
                405                 410                 415     


Gln Lys Ile Gly Ile Arg Asn Lys Lys Lys Lys Lys Lys Lys Asn Ile 
            420                 425                 430         


Trp Pro Ser Leu Glu Thr Asn Thr Thr Val Asn Glu Arg Ser Lys Tyr 
        435                 440                 445             


Asn Leu Gly Lys Ser Phe Lys Ala Glu Ala Phe Leu Ser Val His Glu 
    450                 455                 460                 


Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Thr Lys Glu Glu Pro 
465                 470                 475                 480 


Asn Asn Lys Glu Ile Asn Ala Ser Lys Val Glu Gly Ile Ile Glu Lys 
                485                 490                 495     


Lys Ile Arg Asp Met Tyr Lys Leu Tyr Asp Thr Phe Ala Asn Gly Glu 
            500                 505                 510         


Ile Asn Ser Lys Glu Glu Leu Lys Glu Tyr Leu Lys Gly Lys Asp Ile 
        515                 520                 525             


Glu Ile Val His Leu Pro Lys Gln Met Ile Ala Ile Leu Glu Ser Lys 
    530                 535                 540                 


Pro Lys Asp Met Val Lys Glu Ala Lys Arg Lys Gln Arg Lys Met Val 
545                 550                 555                 560 


Lys Asp Thr Lys Lys Leu Leu Ala Ala Leu Glu Lys Gln Thr Gln Gly 
                565                 570                 575     


Glu Ile Glu Asp Gly Gly Arg Asn Ile Arg Leu Leu Lys Ser Gly Glu 
            580                 585                 590         


Ile Ala Arg Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln 
        595                 600                 605             


Lys Asp Asn Glu Gly Asn Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr 
    610                 615                 620                 


Glu Tyr Gln Met Leu Gln Arg Ser Leu Ala Leu Tyr Asn Lys Glu Glu 
625                 630                 635                 640 


Lys Pro Thr Arg Tyr Phe Arg Gln Val Asn Leu Ile Asn Ser Ser Asn 
                645                 650                 655     


Pro His Pro Phe Leu Lys Trp Thr Lys Trp Glu Glu Cys Asn Asn Ile 
            660                 665                 670         


Leu Ser Phe Tyr Arg Ser Tyr Leu Thr Lys Lys Ile Glu Phe Leu Asn 
        675                 680                 685             


Lys Leu Lys Pro Glu Asp Trp Glu Lys Asn Gln Tyr Phe Leu Lys Leu 
    690                 695                 700                 


Lys Glu Pro Lys Thr Asn Arg Glu Thr Leu Val Gln Gly Trp Lys Asn 
705                 710                 715                 720 


Gly Phe Asn Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg Glu Trp 
                725                 730                 735     


Phe Lys Arg His Gln Asn Asp Ser Glu Glu Tyr Lys Lys Val Glu Ala 
            740                 745                 750         


Leu Asp Arg Val Gly Leu Val Thr Lys Val Ile Pro Leu Phe Phe Lys 
        755                 760                 765             


Glu Glu Tyr Phe Lys Glu Asp Ala Gln Lys Glu Ile Asn Asn Cys Val 
    770                 775                 780                 


Gln Pro Phe Tyr Ser Phe Pro Tyr Asn Val Gly Asn Ile His Lys Pro 
785                 790                 795                 800 


Asp Glu Lys Asp Phe Leu Pro Ser Glu Glu Arg Lys Lys Leu Trp Gly 
                805                 810                 815     


Asp Lys Lys Tyr Lys Phe Lys Gly Tyr Lys Ala Lys Val Lys Ser Lys 
            820                 825                 830         


Lys Leu Thr Asp Lys Glu Lys Glu Glu Tyr Arg Ser Tyr Leu Glu Phe 
        835                 840                 845             


Gln Ser Trp Asn Lys Phe Glu Arg Glu Leu Arg Leu Val Arg Asn Gln 
    850                 855                 860                 


Asp Ile Val Thr Trp Leu Leu Cys Thr Glu Leu Ile Asp Lys Leu Lys 
865                 870                 875                 880 


Val Glu Gly Leu Asn Val Glu Glu Leu Lys Lys Leu Arg Leu Lys Asp 
                885                 890                 895     


Ile Asp Thr Asp Thr Ala Lys Gln Glu Lys Asn Asn Ile Leu Asn Arg 
            900                 905                 910         


Val Met Pro Met Gln Leu Pro Val Thr Val Tyr Glu Ile Asp Asp Ser 
        915                 920                 925             


His Asn Ile Val Lys Asp Arg Pro Leu His Thr Val Tyr Ile Glu Glu 
    930                 935                 940                 


Thr Lys Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys 
945                 950                 955                 960 


Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Val Asp Thr Ser Ser Glu 
                965                 970                 975     


Ala Glu Leu Lys Ser Lys Pro Ile Ser Lys Ser Val Val Glu Tyr Glu 
            980                 985                 990         


Leu Gly Glu Tyr Gln Asn Ala Arg  Ile Glu Thr Ile Lys  Asp Met Leu 
        995                 1000                 1005             


Leu Leu  Glu Glu Thr Leu Ile  Lys Lys Tyr Lys Thr  Leu Pro Thr 
    1010                 1015                 1020             


Asn Lys  Phe Lys Lys Met Leu  Lys Gly Trp Leu Glu  Gly Lys Asp 
    1025                 1030                 1035             


Glu Ala  Asp Lys Ala Arg Phe  Gln Asn Asp Val Asp  Leu Leu Val 
    1040                 1045                 1050             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Arg Asn 
    1055                 1060                 1065             


Arg Ile  Ala Phe Ala Asn Ile  Asn Pro Phe Ser Leu  Ser Ser Ala 
    1070                 1075                 1080             


Asn Thr  Ser Glu Glu Lys Lys  Leu Asp Ile Ala Asn  Gln Leu Lys 
    1085                 1090                 1095             


Asp Lys  Thr His Lys Thr Ile  Glu Lys Ile Ile Lys  Ile Glu Lys 
    1100                 1105                 1110             


Pro Ile  Glu Thr Lys Glu 
    1115                 


<210>  1337
<211>  1135
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1337

Met Asn Thr Val Pro Ala Ser Glu Asn Lys Gly Gln Ser Arg Thr Val 
1               5                   10                  15      


Glu Asp Asp Pro Gln Tyr Phe Gly Leu Tyr Leu Asn Leu Ala Arg Glu 
            20                  25                  30          


Asn Leu Ile Glu Val Glu Ser His Val Arg Ile Lys Phe Gly Lys Lys 
        35                  40                  45              


Lys Leu Asn Glu Glu Ser Leu Lys Gln Ser Leu Leu Cys Asp His Leu 
    50                  55                  60                  


Leu Ser Val Asp Arg Trp Thr Lys Val Tyr Gly His Ser Arg Arg Tyr 
65                  70                  75                  80  


Leu Pro Phe Leu His Tyr Phe Asp Pro Asp Ser Gln Ile Glu Lys Asp 
                85                  90                  95      


His Asp Ser Lys Thr Gly Val Asp Pro Asp Ser Ala Gln Arg Leu Ile 
            100                 105                 110         


Arg Glu Leu Tyr Ser Leu Leu Asp Phe Leu Arg Asn Asp Phe Ser His 
        115                 120                 125             


Asn Arg Leu Asp Gly Thr Thr Phe Glu His Leu Glu Val Ser Pro Asp 
    130                 135                 140                 


Ile Ser Ser Phe Ile Thr Gly Thr Tyr Ser Leu Ala Cys Gly Arg Ala 
145                 150                 155                 160 


Gln Ser Arg Phe Ala Asp Phe Phe Lys Pro Asp Asp Phe Val Leu Ala 
                165                 170                 175     


Lys Asn Arg Lys Glu Gln Leu Ile Ser Val Ala Asp Gly Lys Glu Cys 
            180                 185                 190         


Leu Thr Val Ser Gly Leu Ala Phe Phe Ile Cys Leu Phe Leu Asp Arg 
        195                 200                 205             


Glu Gln Ala Ser Gly Met Leu Ser Arg Ile Arg Gly Phe Lys Arg Thr 
    210                 215                 220                 


Asp Glu Asn Trp Ala Arg Ala Val His Glu Thr Phe Cys Asp Leu Cys 
225                 230                 235                 240 


Ile Arg His Pro His Asp Arg Leu Glu Ser Ser Asn Thr Lys Glu Ala 
                245                 250                 255     


Leu Leu Leu Asp Met Leu Asn Glu Leu Asn Arg Cys Pro Arg Ile Leu 
            260                 265                 270         


Tyr Asp Met Leu Pro Glu Glu Glu Arg Ala Gln Phe Leu Pro Ala Leu 
        275                 280                 285             


Asp Glu Asn Ser Met Asn Asn Leu Ser Glu Asn Ser Leu Asn Glu Glu 
    290                 295                 300                 


Ser Arg Leu Leu Trp Asp Gly Ser Ser Asp Trp Ala Glu Ala Leu Thr 
305                 310                 315                 320 


Lys Arg Ile Arg His Gln Asp Arg Phe Pro Tyr Leu Met Leu Arg Phe 
                325                 330                 335     


Ile Glu Glu Met Asp Leu Leu Lys Gly Ile Arg Phe Arg Val Asp Leu 
            340                 345                 350         


Gly Glu Ile Glu Leu Asp Ser Tyr Ser Lys Lys Val Gly Arg Asn Gly 
        355                 360                 365             


Glu Tyr Asp Arg Thr Ile Thr Asp His Ala Leu Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Asp Phe Gln Asn Glu Glu Glu Val Ser Arg Met Ile Ser Gly Glu 
385                 390                 395                 400 


Ala Ser Tyr Pro Val Arg Phe Ser Leu Phe Ala Pro Arg Tyr Ala Ile 
                405                 410                 415     


Tyr Asp Asn Lys Ile Gly Tyr Cys His Thr Ser Asp Pro Val Tyr Pro 
            420                 425                 430         


Lys Ser Lys Thr Gly Glu Lys Arg Ala Leu Ser Asn Pro Arg Ser Met 
        435                 440                 445             


Gly Phe Ile Ser Val His Asp Leu Arg Lys Leu Leu Leu Met Glu Leu 
    450                 455                 460                 


Leu Cys Glu Gly Ser Phe Ser Arg Met Gln Ser Asp Phe Leu Arg Lys 
465                 470                 475                 480 


Ala Asn Arg Ile Leu Asp Glu Thr Ala Glu Gly Lys Leu Gln Phe Ser 
                485                 490                 495     


Ala Leu Phe Pro Glu Met Arg His Arg Phe Ile Pro Pro Gln Asn Pro 
            500                 505                 510         


Lys Ser Lys Asp Arg Arg Glu Lys Ala Glu Thr Thr Leu Glu Lys Tyr 
        515                 520                 525             


Lys Gln Glu Ile Lys Gly Arg Lys Asp Lys Leu Asn Ser Gln Leu Leu 
    530                 535                 540                 


Ser Ala Phe Asp Met Asp Gln Arg Gln Leu Pro Ser Arg Leu Leu Asp 
545                 550                 555                 560 


Glu Trp Met Asn Ile Arg Pro Ala Ser His Ser Val Lys Leu Arg Thr 
                565                 570                 575     


Tyr Val Lys Gln Leu Asn Glu Asp Cys Arg Leu Arg Leu Gln Lys Phe 
            580                 585                 590         


Arg Lys Asp Gly Asp Gly Lys Ala Arg Ala Ile Pro Leu Val Gly Glu 
        595                 600                 605             


Met Ala Thr Phe Leu Ser Gln Asp Ile Val Arg Met Ile Ile Ser Glu 
    610                 615                 620                 


Glu Thr Lys Lys Leu Ile Thr Ser Ala Tyr Tyr Asn Glu Met Gln Arg 
625                 630                 635                 640 


Ser Leu Ala Gln Tyr Ala Gly Glu Glu Asn Arg His Gln Phe Arg Ala 
                645                 650                 655     


Ile Val Ala Glu Leu Arg Leu Leu Asp Pro Ser Ser Gly His Pro Phe 
            660                 665                 670         


Leu Ser Ala Thr Met Glu Thr Ala His Arg Tyr Thr Glu Asp Phe Tyr 
        675                 680                 685             


Lys Cys Tyr Leu Glu Lys Lys Arg Glu Trp Leu Ala Lys Thr Phe Tyr 
    690                 695                 700                 


Arg Pro Glu Gln Asp Glu Asn Thr Lys Arg Arg Ile Ser Val Phe Phe 
705                 710                 715                 720 


Val Pro Asp Gly Glu Ala Arg Lys Leu Leu Pro Leu Leu Ile Arg Arg 
                725                 730                 735     


Arg Met Lys Glu Gln Asn Asp Leu Gln Asp Trp Ile Arg Asn Lys Gln 
            740                 745                 750         


Ala His Pro Ile Asp Leu Pro Ser His Leu Phe Asp Ser Lys Ile Met 
        755                 760                 765             


Glu Leu Leu Lys Val Lys Asp Gly Lys Lys Lys Trp Asn Glu Ala Phe 
    770                 775                 780                 


Lys Asp Trp Trp Ser Thr Lys Tyr Pro Asp Gly Met Gln Pro Phe Tyr 
785                 790                 795                 800 


Gly Leu Arg Arg Glu Leu Asn Ile His Gly Lys Ser Val Ser Tyr Ile 
                805                 810                 815     


Pro Ser Asp Gly Lys Lys Phe Ala Tyr Cys Tyr Thr His Leu Met Glu 
            820                 825                 830         


Lys Thr Val Gln Asp Lys Lys Arg Glu Leu Arg Thr Ala Gly Lys Pro 
        835                 840                 845             


Val Pro Pro Asp Leu Ala Ala Asp Ile Lys Arg Ser Phe His Arg Ala 
    850                 855                 860                 


Val Asn Glu Arg Glu Phe Met Leu Arg Leu Val Gln Glu Asp Asp Arg 
865                 870                 875                 880 


Leu Met Leu Met Ala Ile Asn Lys Met Met Thr Asp Arg Glu Glu Asp 
                885                 890                 895     


Ile Leu Pro Gly Leu Lys Asn Ile Asp Ser Ile Leu Asp Glu Glu Asn 
            900                 905                 910         


Gln Phe Ser Leu Ala Val His Ala Lys Val Leu Glu Lys Glu Gly Glu 
        915                 920                 925             


Gly Gly Asp Asn Ser Leu Ser Leu Val Pro Ala Thr Ile Glu Ile Lys 
    930                 935                 940                 


Ser Lys Arg Lys Asp Trp Ser Lys Tyr Ile Arg Tyr Arg Tyr Asp Arg 
945                 950                 955                 960 


Arg Val Pro Gly Leu Met Ser His Phe Pro Glu His Lys Ala Thr Leu 
                965                 970                 975     


Asp Glu Val Lys Thr Leu Leu Gly Glu Tyr Asp Arg Cys Arg Ile Lys 
            980                 985                 990         


Ile Phe Asp Trp Ala Phe Ala Leu  Glu Gly Ala Ile Met  Ser Asp Arg 
        995                 1000                 1005             


Asp Leu  Lys Pro Tyr Leu His  Glu Ser Ser Ser Arg  Glu Gly Lys 
    1010                 1015                 1020             


Ser Gly  Glu His Ser Thr Leu  Val Lys Met Leu Val  Glu Lys Lys 
    1025                 1030                 1035             


Gly Cys  Leu Thr Pro Asp Glu  Ser Gln Tyr Leu Ile  Leu Ile Arg 
    1040                 1045                 1050             


Asn Lys  Ala Ala His Asn Gln  Phe Pro Cys Ala Ala  Glu Met Pro 
    1055                 1060                 1065             


Leu Ile  Tyr Arg Asp Val Ser  Ala Lys Val Gly Ser  Ile Glu Gly 
    1070                 1075                 1080             


Ser Ser  Ala Lys Asp Leu Pro  Glu Gly Ser Ser Leu  Val Asp Ser 
    1085                 1090                 1095             


Leu Trp  Lys Lys Tyr Glu Met  Ile Ile Arg Lys Ile  Leu Pro Ile 
    1100                 1105                 1110             


Leu Asp  Pro Glu Asn Arg Phe  Phe Gly Lys Leu Leu  Asn Asn Met 
    1115                 1120                 1125             


Ser Gln  Pro Ile Asn Asp Leu  
    1130                 1135 


<210>  1338
<211>  1142
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1338

Met Glu Asn Asn Asn Asn Thr Lys Glu Ser Thr Tyr Thr Leu Asp Asn 
1               5                   10                  15      


Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val Tyr 
            20                  25                  30          


Ile Thr Val Asn His Ile Asn Lys Thr Leu Glu Leu Lys Asn Lys Lys 
        35                  40                  45              


Asp Gln Glu Ile Ile Ile Asp Asn Asp Gln Asp Ile Leu Ala Ile Lys 
    50                  55                  60                  


Thr Leu Trp Glu Asn Val Asn Gly Asp Leu Asn Lys Thr Glu Arg Leu 
65                  70                  75                  80  


Arg Glu Leu Met Ile Lys His Phe Pro Phe Leu Glu Thr Ala Ile Tyr 
                85                  90                  95      


Ser Lys Asn Lys Glu Asp Asn Glu Glu Val Lys Gln Glu Lys Gln Ala 
            100                 105                 110         


Ala Ala Gln Ser Phe Lys Ser Leu Lys His Cys Leu Ile Leu Phe Leu 
        115                 120                 125             


Glu Lys Leu Gln Glu Ala Arg Asn Tyr Tyr Ser His Tyr Lys Tyr Ser 
    130                 135                 140                 


Glu Ser Thr Lys Glu Pro Met Leu Glu Lys Glu Leu Leu Lys Lys Met 
145                 150                 155                 160 


Tyr Asn Ile Phe Asp Glu Asn Ile Gln Leu Val Lys Lys Asp Tyr Gln 
                165                 170                 175     


His Asn Lys Asp Ile Asn Pro Asp Glu Asp Phe Lys His Leu Asp Arg 
            180                 185                 190         


Thr Glu Glu Glu Phe Asn Tyr Tyr Phe Thr Lys Asp Lys Lys Gly Asn 
        195                 200                 205             


Ile Thr Glu Ser Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys 
    210                 215                 220                 


Lys Asp Ala Ile Trp Met Gln Gln Lys Leu Arg Gly Phe Lys Asp Asn 
225                 230                 235                 240 


Arg Glu Asp Lys Lys Lys Met Thr His Glu Val Phe Cys Arg Arg Arg 
                245                 250                 255     


Ile Leu Leu Pro Lys Leu Arg Leu Glu Ser Thr Gln Thr Gln Asp Trp 
            260                 265                 270         


Ile Leu Leu Asp Met Leu Asn Glu Leu Ile Arg Cys Pro Lys Ser Leu 
        275                 280                 285             


Tyr Glu Arg Leu Gln Gly Ala Asp Arg Lys Lys Phe Asn Val Pro Phe 
    290                 295                 300                 


Asp Pro Ala Asp Glu Asp Tyr Asp Ala Glu Gln Glu Pro Phe Lys Asn 
305                 310                 315                 320 


Thr Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr 
                325                 330                 335     


Phe Asp Tyr Asn Glu Ile Phe Thr Asn Leu Arg Phe Gln Ile Asp Leu 
            340                 345                 350         


Gly Thr Tyr His Phe Ser Ile Tyr Lys Lys Arg Ile Gly Gly Leu Glu 
        355                 360                 365             


Glu Asp Arg His Leu Thr His Lys Leu Tyr Gly Phe Glu Arg Ile Gln 
    370                 375                 380                 


Glu Phe Asp Lys Gln Asn Arg Asn Asp Glu Trp Lys Ala Ile Val Lys 
385                 390                 395                 400 


Asp Leu Asp Thr Tyr Glu Thr Ser Asn Glu Pro Tyr Ile Ser Glu Thr 
                405                 410                 415     


Thr Pro His Tyr His Leu Glu Asn Gln Lys Ile Gly Ile Arg Phe Arg 
            420                 425                 430         


Asn Gly Asn Asn Asp Ile Trp Pro Ser Leu Glu Thr Tyr Gly Glu Asn 
        435                 440                 445             


Asn Glu Lys Ser Lys Tyr Lys Leu Asp Lys Gln Tyr Gln Ala Glu Ala 
    450                 455                 460                 


Phe Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu 
465                 470                 475                 480 


Leu Lys Lys Glu Asn Thr Asp Asn Gly Lys Lys Asn Lys Lys Val Arg 
                485                 490                 495     


Thr Lys Lys Lys Gly Asn Lys Asn Asn Glu Gln Glu Lys His Lys Ile 
            500                 505                 510         


Glu Glu Ile Ile Glu Asn Lys Ile Lys Asp Ile Tyr Thr Leu Tyr Asp 
        515                 520                 525             


Ala Phe Ala Asn Gly Glu Ile Asn Ser Lys Asp Glu Leu Glu Lys Tyr 
    530                 535                 540                 


Leu Lys Gly Lys Asp Ile Lys Ile Val His Leu Pro Lys Gln Met Ile 
545                 550                 555                 560 


Ala Ile Leu Glu Ser Lys Pro Lys Asp Met Val Lys Glu Ala Lys Arg 
                565                 570                 575     


Lys Gln Lys Glu Met Val Lys Asp Thr Lys Lys Leu Leu Ala Thr Leu 
            580                 585                 590         


Glu Lys Gln Thr Gln Arg Glu Ile Glu Asp Asp Gly Arg Asn Val Arg 
        595                 600                 605             


Leu Leu Lys Ser Gly Glu Ile Ala Arg Trp Leu Val Asn Asp Met Met 
    610                 615                 620                 


Arg Phe Gln Pro Val Gln Arg Asp Glu Lys Gly Glu Pro Leu Asn Asn 
625                 630                 635                 640 


Ser Lys Ala Asn Ser Thr Glu Tyr Gln Met Leu Gln Arg Ser Leu Ala 
                645                 650                 655     


Leu Tyr Ser Lys Glu Glu Lys Pro Thr Arg Tyr Phe Arg Gln Ile Asn 
            660                 665                 670         


Leu Ile Glu Ser Ser Asn Pro His Pro Phe Leu Lys Trp Thr Lys Trp 
        675                 680                 685             


Glu Glu Cys Asn Asn Ile Leu Ser Phe Tyr His Arg Tyr Leu Thr Lys 
    690                 695                 700                 


Lys Ile Glu Phe Leu Asn Glu Leu Lys Pro Ala Asp Trp Lys Asn Asn 
705                 710                 715                 720 


Gln Tyr Phe Leu Lys Leu Lys Glu Pro Lys Thr Asn Arg Glu Thr Leu 
                725                 730                 735     


Val Arg Gly Trp Lys Asn Gly Phe Asn Leu Pro Arg Gly Ile Phe Thr 
            740                 745                 750         


Lys Pro Ile Lys Asp Trp Phe Lys Arg His Glu Asn Asp Ser Glu Glu 
        755                 760                 765             


Tyr Lys Lys Val Glu Ala Leu Asp Arg Val Gly Leu Val Thr Lys Val 
    770                 775                 780                 


Ile Pro Leu Phe Phe Lys Glu Glu Tyr Ser Lys Glu Asp Thr Gln Lys 
785                 790                 795                 800 


Glu Ile Asn Asn Cys Val Gln Pro Phe Tyr Ser Phe Pro Tyr Asn Val 
                805                 810                 815     


Gly Asn Ile His Lys Leu Glu Glu Lys Asn Phe Leu His Arg Glu Glu 
            820                 825                 830         


Arg Arg Glu Leu Trp Gly Glu Lys Lys Asp Lys Phe Lys Gly Tyr Lys 
        835                 840                 845             


Glu Lys Val Lys Ser Lys Lys Leu Thr Asp Lys Glu Lys Glu Glu Tyr 
    850                 855                 860                 


Arg Ser Tyr Leu Glu Phe Gln Ser Trp Asn Lys Phe Glu Arg Glu Leu 
865                 870                 875                 880 


Arg Leu Val Arg Asn Gln Asp Ile Val Thr Trp Leu Leu Cys Thr Glu 
                885                 890                 895     


Leu Ile Asp Lys Leu Lys Val Asp Glu Leu Asn Ile Glu Glu Leu Gln 
            900                 905                 910         


Lys Leu Arg Leu Lys Asp Ile Asp Thr Asp Thr Ala Lys Lys Glu Lys 
        915                 920                 925             


Asn Asn Ile Leu Asn Lys Ile Met Pro Met Gln Leu Pro Val Thr Val 
    930                 935                 940                 


Tyr Glu Val Asp Asp Ser Tyr Lys Ile Val Lys Asp Lys Pro Leu His 
945                 950                 955                 960 


Thr Ile Tyr Ile Glu Glu Lys Glu Thr Lys Leu Leu Lys Gln Gly Asn 
                965                 970                 975     


Phe Lys Ala Leu Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe 
            980                 985                 990         


Val Asp Thr Ser Ser Glu Glu Cys  Phe Lys Asp Lys Pro  Ile Ser Lys 
        995                 1000                 1005             


Leu Val  Val Glu Tyr Glu Leu  Gly Glu Tyr Gln Glu  Ala Arg Ile 
    1010                 1015                 1020             


Glu Ile  Ile Lys Asp Met Leu  Ala Leu Glu Glu Thr  Leu Ile Asn 
    1025                 1030                 1035             


Lys Tyr  Lys Lys Asn Leu Pro  Thr Tyr Lys Phe Ser  Asp Met Leu 
    1040                 1045                 1050             


Asn Ser  Trp Leu Glu Gly Lys  Asp Gly Ala Asp Lys  Ala Arg Phe 
    1055                 1060                 1065             


Gln Asn  Asp Val Lys Leu Leu  Thr Ala Val Arg Asn  Ala Phe Ser 
    1070                 1075                 1080             


His Asn  Gln Tyr Pro Met Arg  Asn Arg Ile Ala Phe  Ala Asn Ile 
    1085                 1090                 1095             


Asn Pro  Tyr Ser Leu Ser Ser  Ala Asn Asn Ser Glu  Glu Lys Gly 
    1100                 1105                 1110             


Leu Gly  Ile Ala Asn Gln Leu  Lys Asp Ile Thr His  Arg Ile Ile 
    1115                 1120                 1125             


Gly Lys  Ile Lys Glu Ile Glu  Met Gln Ile Glu Asn  Lys Lys 
    1130                 1135                 1140         


<210>  1339
<211>  1135
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1339

Met Asn Thr Val Pro Ala Ser Glu Asn Lys Gly Gln Ser Arg Thr Val 
1               5                   10                  15      


Glu Asp Asp Pro Gln Tyr Phe Gly Leu Tyr Leu Asn Leu Ala Arg Glu 
            20                  25                  30          


Asn Leu Ile Glu Val Glu Ser His Val Arg Ile Lys Phe Gly Lys Lys 
        35                  40                  45              


Lys Leu Asn Glu Glu Ser Leu Lys Gln Ser Leu Leu Cys Asp His Leu 
    50                  55                  60                  


Leu Ser Val Asp Arg Trp Thr Lys Val Tyr Gly His Ser Arg Arg Tyr 
65                  70                  75                  80  


Leu Pro Phe Leu His Tyr Phe Asp Pro Asp Ser Gln Ile Glu Lys Asp 
                85                  90                  95      


His Asp Ser Lys Thr Gly Val Asp Pro Asp Ser Ala Gln Arg Leu Ile 
            100                 105                 110         


Arg Glu Leu Tyr Ser Leu Leu Asp Phe Leu Arg Asn Asp Phe Ser His 
        115                 120                 125             


Asn Arg Leu Asp Gly Thr Thr Phe Glu His Leu Glu Val Ser Pro Asp 
    130                 135                 140                 


Ile Ser Ser Phe Ile Thr Gly Thr Tyr Ser Leu Ala Cys Gly Arg Ala 
145                 150                 155                 160 


Gln Ser Arg Phe Ala Asp Phe Phe Lys Pro Asp Asp Phe Val Leu Ala 
                165                 170                 175     


Lys Asn Arg Lys Glu Gln Leu Ile Ser Val Ala Asp Gly Lys Glu Cys 
            180                 185                 190         


Leu Thr Val Ser Gly Leu Ala Phe Phe Ile Cys Leu Phe Leu Asp Arg 
        195                 200                 205             


Glu Gln Ala Ser Gly Met Leu Ser Arg Ile Arg Gly Phe Lys Arg Thr 
    210                 215                 220                 


Asp Glu Asn Trp Ala Arg Ala Val His Glu Thr Phe Cys Asp Leu Cys 
225                 230                 235                 240 


Ile Arg His Pro His Asp Arg Leu Glu Ser Ser Asn Thr Lys Glu Ala 
                245                 250                 255     


Leu Leu Leu Asp Met Leu Asn Glu Leu Asn Arg Cys Pro Arg Ile Leu 
            260                 265                 270         


Tyr Asp Met Leu Pro Glu Glu Glu Arg Ala Gln Phe Leu Pro Ala Leu 
        275                 280                 285             


Asp Glu Asn Ser Met Asn Asn Leu Ser Glu Asn Ser Leu Asn Glu Glu 
    290                 295                 300                 


Ser Arg Leu Leu Trp Asp Gly Ser Ser Asp Trp Ala Glu Ala Leu Thr 
305                 310                 315                 320 


Lys Arg Ile Arg His Gln Asp Arg Phe Pro Tyr Leu Met Leu Arg Phe 
                325                 330                 335     


Ile Glu Glu Met Asp Leu Leu Lys Gly Ile Arg Phe Arg Val Asp Leu 
            340                 345                 350         


Gly Glu Ile Glu Leu Asp Ser Tyr Ser Lys Lys Val Gly Arg Asn Gly 
        355                 360                 365             


Glu Tyr Asp Arg Thr Ile Thr Asp His Ala Leu Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Asp Phe Gln Asn Glu Glu Glu Val Ser Arg Met Ile Ser Gly Glu 
385                 390                 395                 400 


Ala Ser Tyr Pro Val Arg Phe Ser Leu Phe Ala Pro Arg Tyr Ala Ile 
                405                 410                 415     


Tyr Asp Asn Lys Ile Gly Tyr Cys His Thr Ser Asp Pro Val Tyr Pro 
            420                 425                 430         


Lys Ser Lys Thr Gly Glu Lys Arg Ala Leu Ser Asn Pro Arg Ser Met 
        435                 440                 445             


Gly Phe Ile Ser Val His Asp Leu Arg Lys Leu Leu Leu Met Glu Leu 
    450                 455                 460                 


Leu Cys Glu Gly Ser Phe Ser Arg Met Gln Ser Asp Phe Leu Arg Lys 
465                 470                 475                 480 


Ala Asn Arg Ile Leu Asp Glu Thr Ala Glu Gly Lys Leu Gln Phe Ser 
                485                 490                 495     


Ala Leu Phe Pro Glu Met Arg His Arg Phe Ile Pro Pro Gln Asn Pro 
            500                 505                 510         


Lys Ser Lys Asp Arg Arg Glu Lys Ala Glu Thr Thr Leu Glu Lys Tyr 
        515                 520                 525             


Lys Gln Glu Ile Lys Gly Arg Lys Asp Lys Leu Asn Ser Gln Leu Leu 
    530                 535                 540                 


Ser Ala Phe Asp Met Asp Gln Arg Gln Leu Pro Ser Arg Leu Leu Asp 
545                 550                 555                 560 


Glu Trp Met Asn Ile Arg Pro Ala Ser His Ser Val Lys Leu Arg Thr 
                565                 570                 575     


Tyr Val Lys Gln Leu Asn Glu Asp Cys Arg Leu Arg Leu Gln Lys Phe 
            580                 585                 590         


Arg Lys Asp Gly Asp Gly Lys Ala Arg Ala Ile Pro Leu Val Gly Glu 
        595                 600                 605             


Met Ala Thr Phe Leu Ser Gln Asp Ile Val Arg Met Ile Ile Ser Glu 
    610                 615                 620                 


Glu Thr Lys Lys Leu Ile Thr Ser Ala Tyr Tyr Asn Glu Met Gln Arg 
625                 630                 635                 640 


Ser Leu Ala Gln Tyr Ala Gly Glu Glu Asn Arg Arg Gln Phe Arg Ala 
                645                 650                 655     


Ile Val Ala Glu Leu Arg Leu Leu Asp Pro Ser Ser Gly His Pro Phe 
            660                 665                 670         


Leu Ser Ala Thr Met Glu Thr Ala His Arg Tyr Thr Glu Asp Phe Tyr 
        675                 680                 685             


Lys Cys Tyr Leu Glu Lys Lys Arg Glu Trp Leu Ala Lys Thr Phe Tyr 
    690                 695                 700                 


Arg Pro Glu Gln Asp Glu Asn Thr Lys Arg Arg Ile Ser Val Phe Phe 
705                 710                 715                 720 


Val Pro Asp Gly Glu Ala Arg Lys Leu Leu Pro Leu Leu Ile Arg Arg 
                725                 730                 735     


Arg Met Lys Glu Gln Asn Asp Leu Gln Asp Trp Ile Arg Asn Lys Gln 
            740                 745                 750         


Ala His Pro Ile Asp Leu Pro Ser His Leu Phe Asp Ser Lys Val Met 
        755                 760                 765             


Glu Leu Leu Lys Val Lys Asp Gly Lys Lys Lys Trp Asn Glu Ala Phe 
    770                 775                 780                 


Lys Asp Trp Trp Ser Thr Lys Tyr Pro Asp Gly Met Gln Pro Phe Tyr 
785                 790                 795                 800 


Gly Leu Arg Arg Glu Leu Asn Ile His Gly Lys Ser Val Ser Tyr Ile 
                805                 810                 815     


Pro Ser Asp Gly Lys Lys Phe Ala Asp Cys Tyr Thr His Leu Met Glu 
            820                 825                 830         


Lys Thr Val Arg Asp Lys Lys Arg Glu Leu Arg Thr Ala Gly Lys Pro 
        835                 840                 845             


Val Pro Pro Asp Leu Ala Ala Tyr Ile Lys Arg Ser Phe His Arg Ala 
    850                 855                 860                 


Val Asn Glu Arg Glu Phe Met Leu Arg Leu Val Gln Glu Asp Asp Arg 
865                 870                 875                 880 


Leu Met Leu Met Ala Ile Asn Lys Ile Met Thr Asp Arg Glu Glu Asp 
                885                 890                 895     


Ile Leu Pro Gly Leu Lys Asn Ile Asp Ser Ile Leu Asp Lys Glu Asn 
            900                 905                 910         


Gln Phe Ser Leu Ala Val His Ala Lys Val Leu Glu Lys Glu Gly Glu 
        915                 920                 925             


Gly Gly Asp Asn Ser Leu Ser Leu Val Pro Ala Thr Ile Glu Ile Lys 
    930                 935                 940                 


Ser Lys Arg Lys Asp Trp Ser Lys Tyr Ile Arg Tyr Arg Tyr Asp Arg 
945                 950                 955                 960 


Arg Val Pro Gly Leu Met Ser His Phe Pro Glu His Lys Ala Thr Leu 
                965                 970                 975     


Asp Glu Val Lys Thr Leu Leu Gly Glu Tyr Asp Arg Cys Arg Ile Lys 
            980                 985                 990         


Ile Phe Asp Trp Ala Phe Ala Leu  Glu Gly Ala Ile Met  Ser Asp Arg 
        995                 1000                 1005             


Asp Leu  Lys Pro Tyr Leu His  Glu Ser Ser Ser Arg  Glu Gly Lys 
    1010                 1015                 1020             


Ser Gly  Glu His Ser Thr Leu  Val Lys Met Leu Val  Glu Lys Lys 
    1025                 1030                 1035             


Gly Cys  Leu Thr Pro Asp Glu  Ser Gln Tyr Leu Ile  Leu Ile Arg 
    1040                 1045                 1050             


Asn Lys  Ala Ala His Asn Gln  Phe Pro Cys Ala Ala  Glu Ile Pro 
    1055                 1060                 1065             


Leu Ile  Tyr Arg Asp Val Ser  Ala Lys Val Gly Ser  Ile Glu Gly 
    1070                 1075                 1080             


Ser Ser  Ala Lys Asp Leu Pro  Glu Gly Ser Ser Leu  Val Asp Ser 
    1085                 1090                 1095             


Leu Trp  Lys Lys Tyr Glu Met  Ile Ile Arg Lys Ile  Leu Pro Ile 
    1100                 1105                 1110             


Leu Asp  Pro Glu Asn Arg Phe  Phe Gly Lys Leu Leu  Asn Asn Met 
    1115                 1120                 1125             


Ser Gln  Pro Ile Asn Asp Leu  
    1130                 1135 


<210>  1340
<211>  1175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1340

Met Thr Glu Gln Asn Glu Arg Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Thr His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Tyr Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Glu Lys Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Thr Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Ile Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Ala 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Leu Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Glu Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Gly Glu Ile Asp Thr Leu Asp 
    530                 535                 540                 


Arg Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Glu Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Ser Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Leu Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asn Tyr Pro Phe Asn Val Gly Asn Ile Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Asp Leu Glu Ala Trp Ser Gln Ser Thr Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Ala Gly Ile Lys Tyr Ala Ser Pro Gly Asn 
    850                 855                 860                 


Lys Lys Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Glu Thr 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Lys Ala Asp Lys Ile Asn Leu Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Ala Lys Glu His Pro Tyr Leu Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asp Ile Trp Thr 
945                 950                 955                 960 


Asp Val His Glu Gln Gly Ser Leu Asn Val Leu Asn Arg Val Lys Pro 
                965                 970                 975     


Met Arg Leu Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val 
            980                 985                 990         


His Lys Glu Gln Ala Pro Leu Ala  Thr Val Tyr Ile Glu  Glu Arg Asp 
        995                 1000                 1005             


Thr Lys  Leu Leu Lys Gln Gly  Asn Phe Lys Ser Phe  Val Lys Asp 
    1010                 1015                 1020             


Arg Arg  Leu Asn Gly Leu Phe  Ser Phe Val Asp Thr  Gly Gly Leu 
    1025                 1030                 1035             


Ala Met  Glu Gln Tyr Pro Ile  Ser Lys Leu Arg Val  Glu Tyr Glu 
    1040                 1045                 1050             


Leu Ala  Lys Tyr Gln Thr Ala  Arg Val Cys Ala Phe  Glu Gln Thr 
    1055                 1060                 1065             


Leu Glu  Leu Glu Glu Ser Leu  Leu Thr Arg Cys Pro  His Leu Pro 
    1070                 1075                 1080             


Asp Lys  Asn Phe Arg Lys Met  Leu Glu Ser Trp Ser  Asp Pro Leu 
    1085                 1090                 1095             


Leu Asp  Lys Trp Pro Asp Leu  His Arg Lys Val Arg  Leu Leu Ile 
    1100                 1105                 1110             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1115                 1120                 1125             


Glu Ala  Val Phe Ser Ser Ile  Arg Lys Tyr Asp Pro  Ser Ser Pro 
    1130                 1135                 1140             


Asp Ala  Ile Glu Glu Arg Met  Gly Leu Asn Ile Ala  His Arg Leu 
    1145                 1150                 1155             


Ser Glu  Glu Val Lys Gln Ala  Lys Glu Met Ala Glu  Arg Ile Ile 
    1160                 1165                 1170             


Gln Ala  
    1175 


<210>  1341
<211>  1199
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1341

Met Asn Thr Phe Ile Asp Ser Phe Ile Arg Arg Val Gln Ile Gln Asn 
1               5                   10                  15      


Gln Asn Gln Ser Trp Pro Lys Arg Pro Lys Tyr Val Arg Pro Val Glu 
            20                  25                  30          


Asn Ile Arg Pro Asp Asp Leu Ala Phe Gln Ser His Phe Thr Ala Tyr 
        35                  40                  45              


Leu Asn Met Ala Arg Gln Asn Cys Cys Ile Ile Leu Gly His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Gly Phe Lys Ala Ser Ser Val Lys Asp Thr Thr Leu Thr 
65                  70                  75                  80  


Ser Ser Pro Leu Leu Gly Gln Asn Gly Leu Leu Ser Pro Lys Lys Glu 
                85                  90                  95      


Val Ser Asp Leu Ile Arg Gly Arg Leu Leu Ser Ala Phe Pro Met Leu 
            100                 105                 110         


Asp Pro Met Ile Arg Tyr Arg Lys Ala Val Asp Lys Glu Lys Asp Asp 
        115                 120                 125             


Tyr Ala Arg Ile Ile Ile Thr Ser Glu Asp Val Ser Glu Met Leu Arg 
    130                 135                 140                 


Asp Leu Leu Asp Val Leu Ser Tyr Tyr Arg Asp Met Ala Ser His Val 
145                 150                 155                 160 


Val Phe Asn Asp Asp Arg Ser Val Ser Ala Glu Phe Ala Ser Lys Glu 
                165                 170                 175     


Lys Lys Val Ala Glu Cys Leu Asn Tyr Met Met Thr Val Ser Leu Arg 
            180                 185                 190         


Ile Val Lys Asp Arg Phe Ser Leu Ala Val Ser Asp Leu Asp Phe Tyr 
        195                 200                 205             


Asn Arg Asn Arg Tyr Met Met Val Asn Arg Lys Pro Leu Leu Asn Ala 
    210                 215                 220                 


Gly Phe Ala His Ala Val Arg Thr Glu Asp Tyr Arg Leu Thr Leu Met 
225                 230                 235                 240 


Gly Leu Val Leu Leu Cys Cys Gln Phe Ile Glu Lys Gln Tyr Ala Ser 
                245                 250                 255     


Met Phe Phe Asp Ala Leu Asp Lys His Ser Asn Gly Ala Arg Phe Tyr 
            260                 265                 270         


Gly Ile Ala Asp Ala Met Pro Met Val Asn Val Gly Thr Lys Asp Lys 
        275                 280                 285             


Pro Lys Lys Ile Pro Met Tyr Thr Gly Asp Glu Ala Gln Lys Gln Val 
    290                 295                 300                 


Gln Lys Gln Arg Met Ala Leu Arg Glu Ala Tyr Ser Val Tyr Arg Val 
305                 310                 315                 320 


Arg Ile Pro Lys Glu Arg Leu Glu Ser Thr Arg Ser Asp Met Ala Leu 
                325                 330                 335     


Ala Leu Asp Ile Leu Asn Glu Leu Gly Lys Cys Pro Glu Glu Leu Phe 
            340                 345                 350         


Glu His Leu Ser Pro Glu Asp Arg Glu Ser Phe Lys Asn Glu Glu Gly 
        355                 360                 365             


Val Leu Met Lys Arg Tyr Ser Asp Arg Phe Pro Gln Leu Ala Leu Arg 
    370                 375                 380                 


Trp Leu Asp Glu Asn Glu Lys Phe Asn Asn Leu Arg Phe His Val Thr 
385                 390                 395                 400 


Phe Gly Lys Tyr Arg Trp Leu Phe Cys Gln Asp Lys Lys Cys Ala Asp 
                405                 410                 415     


Gly Ser Val Arg Pro Arg Trp Leu Gln Lys Glu Leu Asn Gly Phe Gly 
            420                 425                 430         


Arg Ile Gln Thr Val Glu Arg Lys Arg Thr Gly Leu Glu Pro Gly Trp 
        435                 440                 445             


Asp Gly Thr Gly Leu Ile Arg Lys Phe Glu Glu Val Val Thr Asp Glu 
    450                 455                 460                 


Val Gln Lys Glu Pro Tyr Ile Thr Asp Phe Arg Thr Gln Tyr Leu Phe 
465                 470                 475                 480 


Asn Arg Asp Lys Ile Gly Ile Ser Leu Ser Glu Tyr Met Pro Gly Ile 
                485                 490                 495     


Gly Asp Ile His Ser Gly Lys Glu Trp Gly Lys His Ala Gly Val Pro 
            500                 505                 510         


Asp Phe Tyr Leu Ser Val Tyr Asp Ile Pro Ala Met Leu Phe Leu Thr 
        515                 520                 525             


Trp Leu Leu Gly Lys Asn Ser Ser Ala Val Glu Lys Leu Leu Ala Asn 
    530                 535                 540                 


Cys Lys Ala Ala Tyr Met Lys Leu Phe Asp Asp Leu Ala Lys Gly Lys 
545                 550                 555                 560 


Trp Glu Gly Glu Arg Asn Val Ser Asp Tyr Cys Ala Gly Glu Gly Thr 
                565                 570                 575     


Val Arg Tyr Thr Leu Arg Trp Tyr Asp Val Pro Met Lys Ile Arg Arg 
            580                 585                 590         


Lys Met Pro Leu Leu Gly Gly Asp Arg Asp Phe Glu Glu Lys Lys Ser 
        595                 600                 605             


Phe Glu Thr Leu Ala Gln Glu Ala Leu Thr Arg Met Leu Gln Arg Thr 
    610                 615                 620                 


Glu Asn Gln Leu Glu Lys Phe Asp Arg Asp Leu Ala Ala Ala Arg Asp 
625                 630                 635                 640 


Leu Lys Ala Asn Lys Gln Gly Lys Asp Arg Phe Val Asp Ile Arg Ala 
                645                 650                 655     


Gly Ser Leu Ala Thr Phe Leu Ala Arg Asp Ile Val Arg Leu Met Pro 
            660                 665                 670         


Val Ser Asp Asn Gly Arg Asn Lys Pro Thr Gly Leu Asn Tyr Ser Ile 
        675                 680                 685             


Val Gln Lys Ala Ile Ala Thr Tyr Lys Pro Ser Glu Gly Gly Leu Asp 
    690                 695                 700                 


Thr Leu Thr Gly Val Phe Arg Asp Ala Arg Ile Ile Gly Val Lys Gly 
705                 710                 715                 720 


Gly Ser His Pro Phe Leu Glu Arg Leu Leu Val Glu Lys Lys Pro Ser 
                725                 730                 735     


Ser Val Leu Ala Leu Tyr Arg His Tyr Leu Glu Tyr Arg Lys Glu Tyr 
            740                 745                 750         


Leu Lys Lys Ala Leu Glu Asp Glu Asn Lys Ala Glu Leu Lys Asn Leu 
        755                 760                 765             


Pro Phe Leu Lys Ser Gly Arg Gln Lys Tyr Ala Val Asp Gln Ala Asp 
    770                 775                 780                 


Tyr Ala Arg Arg Leu Ala Glu Ser Tyr Arg Asn Cys Pro Ile Tyr Leu 
785                 790                 795                 800 


Pro Thr Gly Ile Phe Thr Asp Met Leu Lys Asp Gln Leu Ala Lys Ile 
                805                 810                 815     


Asp Val Met Lys Pro Val Leu Glu Asn Asp Lys Val Asn Ala Ser Tyr 
            820                 825                 830         


Leu Ile Ala Gln Tyr Phe Glu Lys Val Glu His Asp Ser Glu Gln Pro 
        835                 840                 845             


Leu Tyr Arg Leu Lys Arg Asn Tyr Arg Val Phe Asp Leu Leu Glu Phe 
    850                 855                 860                 


Thr Asp Glu Pro Lys Tyr Trp Arg Leu Asn Glu Arg Ser Asp Lys Ala 
865                 870                 875                 880 


Gly Lys Tyr Gly Leu Ala Lys Arg Asn Ile Phe Trp Asn Arg Met Gly 
                885                 890                 895     


Glu Tyr Tyr Lys Gly Leu Lys Lys Phe Tyr Lys Gly Tyr Glu Ser Lys 
            900                 905                 910         


Arg Thr Ala Val Asp Trp Arg Glu Lys Leu Lys Ile Val Glu Ala Glu 
        915                 920                 925             


His Ala Met Trp Asn Arg Leu Lys Asp Ala Ser Gly Glu Ala Arg Leu 
    930                 935                 940                 


Lys Met Lys Asp Gly Val Phe Tyr Ser Arg Leu Leu Ser Ala Arg Lys 
945                 950                 955                 960 


Glu Tyr Asp Asp Cys Glu Arg Ala Leu Arg Arg Leu Lys Val Gln Asp 
                965                 970                 975     


Ile Val Leu Phe Leu Ala Ala Arg Glu Thr Leu Ile Leu Pro Lys Asp 
            980                 985                 990         


Lys Val Phe Arg Leu Lys Asn Leu  Ser Leu Ser Glu Gly  Asn Lys Asn 
        995                 1000                 1005             


Ile Leu  Ser Ser Ala Ile Asp  Glu Phe Ser Val Asp  Val Val Trp 
    1010                 1015                 1020             


Thr Glu  Lys Glu Gly Ala Ala  Lys Val Thr His Ser  Ala Ser Ile 
    1025                 1030                 1035             


Lys Glu  Asn Asp Val Val Ile  Lys Asn Tyr Gly Arg  Met Phe Arg 
    1040                 1045                 1050             


Leu Leu  His Asp Asp Arg Val  Lys Thr Leu Leu Pro  His Ile Tyr 
    1055                 1060                 1065             


Asp Ser  Ala Leu Ser Glu Asn  Ile Thr Gly Asp Arg  Ile Thr Val 
    1070                 1075                 1080             


Lys Asp  Asn Lys Val Ile Ile  Asp Lys Ser Leu Phe  Asp Glu Asp 
    1085                 1090                 1095             


Leu Met  Asn Tyr Asp Leu Arg  Arg His Glu Ile Cys  Glu Ile Ile 
    1100                 1105                 1110             


Leu Arg  Phe Glu Ala Ala Ser  Ile Lys Arg Phe Gly  Leu Asp Gly 
    1115                 1120                 1125             


Arg Val  Asp Phe Lys Ala Ala  Leu Asp Ala Leu Thr  Gly Arg Ser 
    1130                 1135                 1140             


Leu Leu  Asn Asp Glu Asp Ala  Arg Ile Leu Ser Ala  Ile Arg Asn 
    1145                 1150                 1155             


Ala Tyr  Asn His Asn Lys Tyr  Pro Ala Lys Gly Thr  Asp Val Lys 
    1160                 1165                 1170             


Val Asn  Val Met Ala Leu Pro  Lys Leu Thr Glu Asp  Leu Leu Arg 
    1175                 1180                 1185             


Ile Phe  Ser Asp Thr Gly Asn  Asn Arg Val Arg 
    1190                 1195                 


<210>  1342
<211>  1081
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1342

Met Gln Ala Gln Ser Leu Phe Asp Glu Tyr Lys His Leu Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Val Met Ser Ile Met Asn Ile Ile Thr Val Leu Asn His Ile 
            20                  25                  30          


His Gln Ile Ala Gly Leu Lys Arg Asn Glu Leu Gly Asp Asp Asp Asn 
        35                  40                  45              


Ile Tyr Ser His Pro Val Leu Lys Tyr Ile Ala Pro Glu Asn Asn Ser 
    50                  55                  60                  


Thr Thr Leu Pro Glu Lys Arg Asp Leu Ile Lys Glu Leu Leu Leu Glu 
65                  70                  75                  80  


Tyr Leu Pro Phe Leu Glu Ala Met Lys Asp Cys Tyr Lys Glu Val Lys 
                85                  90                  95      


Val Glu Lys Asp Lys Arg Asn Asn Lys Tyr Val Lys Asp Lys Lys Gln 
            100                 105                 110         


Val Phe Ile Arg Asn Tyr Ser Asp Ile Tyr Cys Ile Tyr Trp Thr Leu 
        115                 120                 125             


Tyr Asn Ile Phe Ser Thr Leu Ile Asn Tyr Arg Asp Lys Ser Cys His 
    130                 135                 140                 


Tyr Arg Phe Ile Pro Ser Lys Asp Gln Glu Glu Tyr Ser Lys Arg Thr 
145                 150                 155                 160 


Glu Tyr Asp Thr Val Arg Ile Ile Asn Lys Tyr Tyr Thr Tyr Ala Leu 
                165                 170                 175     


Arg Lys Thr Lys Glu Lys Tyr Gly Tyr Thr Thr Glu Gln Leu Ser Phe 
            180                 185                 190         


Ile Gln Asn Asn Arg Tyr Thr Asp Asp Lys Lys Val Asn Phe Asn Phe 
        195                 200                 205             


Phe Leu Ser Met Gln Ser Ser Asn Asn Asn Leu Ser His Val Gly Val 
    210                 215                 220                 


Ala Gln Leu Ile Cys Leu Phe Leu Gln Lys Lys Asp Val Asp Asn Phe 
225                 230                 235                 240 


Leu Glu Asn Leu Pro Ile Tyr Asp Asn Arg Tyr Cys Leu Gly Ile Asp 
                245                 250                 255     


Glu His Met Ile Ile Lys Arg Ser Leu Ala Leu His Ser Ile Lys Leu 
            260                 265                 270         


Pro Lys Glu Arg Leu Asn Ser Glu Lys Lys Asp Met Ala Ile Ala Met 
        275                 280                 285             


Asp Met Leu Asn Glu Leu Lys Arg Cys Pro Lys Glu Leu Phe Asn Thr 
    290                 295                 300                 


Leu Pro Phe Asp Lys Gln Glu Arg Phe Arg Ile Ile Ser Ser Asp His 
305                 310                 315                 320 


Lys Glu Val Leu Leu Met Arg Ser Thr Asp Arg Phe Val Pro Leu Ile 
                325                 330                 335     


Leu Gln Tyr Ile Asp Cys Asn Lys Lys Phe Lys Asp Ile Arg Phe His 
            340                 345                 350         


Val Asn Met Gly Lys Leu Arg Tyr Leu Phe Ser Pro Asn Lys Leu Cys 
        355                 360                 365             


Ile Asp Asn Gln Glu Arg Val Arg Met Leu Glu His Leu Leu Asn Gly 
    370                 375                 380                 


Tyr Gly Arg Ile Asp Glu Val Glu Tyr Leu Arg Lys Ala Pro Asn Gly 
385                 390                 395                 400 


Thr Phe Gly Asn Thr Asn Ile Pro Ile Lys Gly Phe Gly Glu Ile Glu 
                405                 410                 415     


Arg Asp Ser Ala Asp Ser Asn Asn Tyr Pro Tyr Ile Val Asp Thr His 
            420                 425                 430         


Thr His Tyr Ile Leu Asn Asn Asn Lys Val Glu Phe Cys Phe Cys Glu 
        435                 440                 445             


Asp Ser Lys Asn Lys Asn Val Phe Pro Thr Ile Glu Lys Glu Ile Asn 
    450                 455                 460                 


Gly Lys Trp Tyr Val Glu Lys Thr Ala Pro His Cys Arg Ile Ser Phe 
465                 470                 475                 480 


Phe Glu Ile Pro Ala Met Ala Phe His Met Phe Leu Cys Gly Ser Glu 
                485                 490                 495     


Lys Thr Glu Lys Leu Ile Lys Asp Val Tyr Asn Asn Tyr Ile Ser Leu 
            500                 505                 510         


Phe Asn Ala Leu Lys Asn Gly Ala Leu Thr Glu Glu Asn Tyr Lys Asp 
        515                 520                 525             


Phe Asn Ile Pro Glu Cys Asp Met Pro Lys Lys Ile Leu Asp Phe Leu 
    530                 535                 540                 


Lys Gly Lys Ala Glu Gly Lys Ser Ile Asp Gly Tyr Val Lys Asn Ile 
545                 550                 555                 560 


Leu Lys Lys Glu Leu Lys Asp Thr Arg Lys Arg Ile Glu Gln Ala Pro 
                565                 570                 575     


Ser Glu Lys Asp Gln Met Pro Ser Lys Arg Asn Lys Ile Gly Thr Lys 
            580                 585                 590         


Ser Tyr Lys Arg Val Leu Thr Gly Lys Leu Ala Asp Phe Leu Ala Lys 
        595                 600                 605             


Asp Ile Val Lys Tyr Gln Pro Thr Leu Cys Ala Gly Asp Asp Tyr Gly 
    610                 615                 620                 


Ile Asp Arg Met Thr Gly Met Asn Tyr Arg Ile Met Gln Ala Thr Ile 
625                 630                 635                 640 


Ala Thr Tyr Asn Asp Asp Asp Asp Phe Asp Thr Phe Tyr Asn Val Phe 
                645                 650                 655     


Lys Met Ala Gly Leu Val Asp Gly Asp Glu Arg Lys Asn His Pro Phe 
            660                 665                 670         


Leu Lys Lys Val Leu Leu Ser Lys Pro Gln Asn Thr Val Ala Phe Asn 
        675                 680                 685             


Ile Lys Tyr Leu Lys Glu Lys Glu Ile Tyr Leu Arg Asn Ile Glu Lys 
    690                 695                 700                 


Lys Asn Ile Ile Pro Pro Phe Val Asn Arg Glu Arg Asn Lys Trp Cys 
705                 710                 715                 720 


Glu Arg Asp Cys Glu Tyr Tyr Arg Ile Leu Gly Glu Asn Leu Leu Asp 
                725                 730                 735     


Leu Pro Ile Glu Leu Pro Arg Gln Met Phe Tyr Lys Asp Ile Arg Ala 
            740                 745                 750         


Gln Leu Glu Pro Leu Met Pro Glu Ile Asp Phe Ser Gln Thr Asn Thr 
        755                 760                 765             


Thr Tyr Leu Ile Ala Glu Tyr Leu Lys Arg Val Arg Gly Asp Asp Phe 
    770                 775                 780                 


Gln Glu Phe Tyr Ser Trp Glu Arg Asn Tyr Arg Tyr Ile Asp Phe Leu 
785                 790                 795                 800 


Lys Cys Ile Arg Asp Asp Asn Gly Arg Ile Cys Ala Gln Tyr Thr Thr 
                805                 810                 815     


Thr Glu Glu Arg Glu Ser Leu Trp Glu Asp Ser Lys Asn Arg Thr Ala 
            820                 825                 830         


Glu Tyr Lys Arg Ser Glu Glu Gln Lys Asn Glu Lys Lys Asp Lys Asn 
        835                 840                 845             


Phe Glu Asp Ser Leu Glu Glu Arg Ile Ser Ser Ser His Ile Lys Phe 
    850                 855                 860                 


Gln Asn Thr Glu Lys His Ile Arg Arg Tyr Lys Val Gln Asp Ala Leu 
865                 870                 875                 880 


Leu Phe Met Ile Ala Glu Lys Gln Phe Gly Lys Tyr Leu Asp Asp Ile 
                885                 890                 895     


Lys Ala Lys Asn Phe Lys Leu Lys Asp Ile Met Pro Asp Thr Asp Lys 
            900                 905                 910         


Gly Ile Leu Ser Glu Thr Met Pro Ile Asp Phe Thr Phe Thr Lys Lys 
        915                 920                 925             


Asn Ile Lys Tyr Asn Ile His Ala Lys Asn Leu Lys Phe Lys Glu Tyr 
    930                 935                 940                 


Gly Asp Leu Phe Ile Leu Ala Asn Asp Lys Arg Leu Glu Ser Leu Trp 
945                 950                 955                 960 


Lys Ile Leu Ala Thr Asp Thr Val Asn Lys Glu Glu Ile Ser Glu Glu 
                965                 970                 975     


Phe Ala Lys Tyr Asp Phe Cys Arg Pro Asp Ile Thr Lys Leu Val Leu 
            980                 985                 990         


Asp Phe Glu Lys Asp Val Leu Glu  Lys Tyr Pro Glu Ile  Ile Glu Glu 
        995                 1000                 1005             


Ala Glu  Lys Glu Tyr Lys Lys  Phe Asp Phe Lys Phe  Ile Leu Asp 
    1010                 1015                 1020             


Trp Leu  Ile Asn Lys Lys Lys  Leu Asn Tyr Gly Ile  Arg Asn Lys 
    1025                 1030                 1035             


Leu Leu  Leu Ile Arg Asn Ala  Phe Asn His Asn Ser  Tyr Pro Asp 
    1040                 1045                 1050             


Lys Lys  Tyr Ala Glu Val Arg  Glu Leu Pro Glu Ile  Ala Thr Asn 
    1055                 1060                 1065             


Leu Lys  Lys Thr Phe Asp Glu  Asn Ala Lys Lys Tyr  Glu 
    1070                 1075                 1080     


<210>  1343
<211>  1057
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1343

Met Thr Ile Lys Glu Gln Ser His Phe Ala Ala Tyr Tyr Asn Met Ala 
1               5                   10                  15      


Arg His Asn Met Tyr Glu Thr Leu Cys Tyr Ile Ser Lys Ile Ser Gly 
            20                  25                  30          


Ile Gln Glu Gly Glu Asp Asn Lys Glu Ser Lys Ile Glu Asp Met Gln 
        35                  40                  45              


Leu Leu Arg Val Leu Thr Thr Lys Gly His Pro Glu Glu Lys Ile Arg 
    50                  55                  60                  


Ile Glu Lys Leu Ile Tyr Lys His Leu Pro Leu Phe Arg Pro Ala Val 
65                  70                  75                  80  


Glu Asp Leu Arg Lys Lys Ser Lys Glu Asn Val Lys Ser Pro Glu Leu 
                85                  90                  95      


Leu Ala Lys Val Ile Lys Asn Trp Ala Lys Val Ile Thr Tyr Tyr Arg 
            100                 105                 110         


Asp Lys Phe Thr His Tyr Val Phe Ile Asp Lys Arg His Glu Asn Lys 
        115                 120                 125             


Glu Phe Leu Asn Ala Glu Met Ser Val Ala Asn Asp Leu Asn Gln Ile 
    130                 135                 140                 


Phe Thr Ala Ser Ala Arg Val Ile Lys Glu Arg Phe Gly Leu Ser Thr 
145                 150                 155                 160 


Glu Leu Glu Phe Leu Thr Lys Gly Arg Tyr Arg Thr Gln Thr Ile Asp 
                165                 170                 175     


Gly Lys Arg Ser Thr Lys Leu Asn Pro Asn Phe Ile Tyr Ser Leu Gln 
            180                 185                 190         


Asp Lys Asn Glu Arg Leu Asn Lys Met Gly Leu Ile Phe Leu Ala Cys 
        195                 200                 205             


Gln Leu Ile Glu Lys Lys Tyr Ala Ser Met Leu Phe Asp Gln Gln Gly 
    210                 215                 220                 


Tyr Met Gly Arg Asp Ile Tyr Phe Asp Phe Thr Pro Ala Gln Cys Lys 
225                 230                 235                 240 


Tyr Ile Arg Glu Val Phe Ser Ala His Arg Ile Val Leu Pro Arg Gly 
                245                 250                 255     


Arg Met Asp Val Glu Arg Asn Glu Ile Thr Ile Ala Met Asp Met Phe 
            260                 265                 270         


Asn Glu Leu Gly Lys Cys Pro Lys Glu Leu Phe Glu Ile Ile Ser Lys 
        275                 280                 285             


Glu Glu Gln Lys Arg Phe Arg Thr Lys Ser Glu Thr Thr Gly Glu Glu 
    290                 295                 300                 


Val Leu Leu Met Arg His Ser Asp Arg Phe Ala Thr Leu Ala Leu Gln 
305                 310                 315                 320 


Tyr Ile Asp Asn Arg Lys Val Phe Glu Lys Ile Arg Phe Gln Leu Ser 
                325                 330                 335     


Leu Gly Lys Tyr Arg Tyr Lys Phe Tyr Asp Lys Thr Cys Val Asp Gly 
            340                 345                 350         


Asp Thr His Val Arg Ile Leu Gln Lys Glu Leu Asn Gly Phe Gly Arg 
        355                 360                 365             


Ile Asn Glu Ile Glu Leu Leu Lys Glu Glu Lys Trp Gly Gly Leu Ile 
    370                 375                 380                 


Arg Lys Phe Glu Asp Ala Lys Ile Asp Thr Ala Glu Thr Lys Pro Tyr 
385                 390                 395                 400 


Ile Thr Asp Gln Tyr Pro Gln Tyr Leu Phe Asn Gly Asn Arg Ile Gly 
                405                 410                 415     


Ile Tyr Phe Asn Ser Ala His Gly Lys Ala Met Arg Asn Gly Ala Tyr 
            420                 425                 430         


Ile Pro Asp Ile Glu Ser Gly Ala His Cys Ile Gln Pro Ile Cys Trp 
        435                 440                 445             


Ile Ser Asn Tyr Glu Leu Pro Ala Leu Ile Phe His His Ile Leu Thr 
    450                 455                 460                 


Lys Asp Glu Lys Lys Ser Leu Thr Glu Lys Ile Ile Ile Asp Cys Val 
465                 470                 475                 480 


Glu Arg Tyr Lys Lys Leu Phe Asn Asp Ile Ala Glu Gly Lys Val Ala 
                485                 490                 495     


Arg Thr Gly Asn Ala Thr Ser Asp Phe Glu Met Ile Ser Lys Glu Tyr 
            500                 505                 510         


Gly Ile Glu Lys Ser Asp Ile Pro Arg Glu Leu Gln Asp Tyr Phe Asn 
        515                 520                 525             


Gly Thr Glu Arg Asp Gly Ile Glu Gln Tyr Ala Lys Ala Gln Ile Arg 
    530                 535                 540                 


Glu Met Ile Glu Glu Asn Arg Ile Arg Leu Glu Gln Phe Asn Ser Lys 
545                 550                 555                 560 


Leu Lys Lys Ile Glu Asp Gly Glu Val Lys Tyr Gly Lys Arg Asp Tyr 
                565                 570                 575     


Thr Glu Ile Arg Thr Gly Glu Leu Ala Gln Tyr Leu Ala Lys Asp Ile 
            580                 585                 590         


Val Met Phe Met Pro Lys Ala Lys Tyr Lys Pro Thr Ser Lys Asn Tyr 
        595                 600                 605             


Asn Val Met Gln Ala Leu Leu Ala Thr Phe Asn Gly Ser Glu Ser Gly 
    610                 615                 620                 


Ser Thr Leu Asp Glu Val Asp Asp Met Phe Asp Asn Ile Lys Ala Cys 
625                 630                 635                 640 


Tyr Trp Lys Asn Glu Ser Asp Asn His Pro Phe Leu Glu Tyr Val Leu 
                645                 650                 655     


Gly Glu Glu Pro Lys Asp Ile Ile Ala Phe Tyr Lys Ile Tyr Leu Glu 
            660                 665                 670         


Leu Arg Gly Glu Tyr Leu Asp Lys Cys Ile Lys Lys Met Asp Leu Ala 
        675                 680                 685             


Thr Ile Pro Phe Ile His Thr Glu Arg Lys Arg Trp Glu Lys Arg Asp 
    690                 695                 700                 


Glu Lys Phe Phe Lys Glu Leu Ala Gln Arg Tyr Ala Thr Gln Pro Ile 
705                 710                 715                 720 


Glu Leu Pro Arg Gly Leu Tyr Asp Arg Ala Ile Lys Glu Tyr Leu Lys 
                725                 730                 735     


Ser Lys Ser Ile Leu Glu Asp Val Ile Ala Gln Glu Gln Cys Asn Val 
            740                 745                 750         


Thr Tyr Leu Ile Ala Arg Tyr Met Gln Asp Val Leu Lys Asp Asp Ser 
        755                 760                 765             


Gln Gln Phe Tyr Ser Leu Pro Arg His Tyr Ser Cys Leu Ser Glu Lys 
    770                 775                 780                 


Asp Lys Tyr Leu Ser Leu Thr Glu Arg Glu Ala Ile Ala Lys Ser Asp 
785                 790                 795                 800 


Ala Leu Asn Asn Phe Lys Lys Arg Glu Arg Glu Lys Glu Asn Glu Asn 
                805                 810                 815     


Arg Arg Gly Asn Arg Arg Tyr Asn Lys Gly Glu Asn Lys Asn Thr Ile 
            820                 825                 830         


Lys Asp Arg Asp Thr Glu Glu Lys Phe Asn Ser Leu Tyr Arg Lys Met 
        835                 840                 845             


Asp Asn Asn Glu Arg Ile Leu Arg Arg Tyr Lys Val Gln Asp Met Leu 
    850                 855                 860                 


Leu Tyr Leu Leu Ala Cys Asp Ile Ile Lys Gly Ile Met Arg Glu Asp 
865                 870                 875                 880 


Phe Gly Tyr Lys Leu Ser Met Ile Thr Asp Gly Lys Asn Ser Asn Phe 
                885                 890                 895     


Phe Asp Tyr Lys Met Pro Glu Phe Lys Thr Thr Ile Thr Leu Lys Glu 
            900                 905                 910         


Gly Lys Lys Phe Thr Ile Lys Gln Gln Tyr Leu Lys Ile Lys Asn Tyr 
        915                 920                 925             


Gly Asp Phe Leu Lys Phe Ile Phe Asp Leu Arg Ile Asp Ser Leu Leu 
    930                 935                 940                 


Ser Asn Gly Thr Lys Val Glu Ile Asp Arg Asn Ile Leu Glu Asp Glu 
945                 950                 955                 960 


Leu Ser Asn Tyr Asp Gly Ser Arg Pro Lys Val Phe Glu Thr Leu Leu 
                965                 970                 975     


Met Ile Glu Lys Ile Val Val Glu Lys His Lys Glu Leu Lys Asp Leu 
            980                 985                 990         


Glu His Ile Thr Phe Gly Asp Val  Leu Asn Val Ile Lys  Met Glu Glu 
        995                 1000                 1005             


Gly Glu  Lys Lys Ile Leu Arg  Leu Ile Arg Asn Ala  Phe Ser His 
    1010                 1015                 1020             


Asn Tyr  Tyr Pro Thr Ile Lys  Asp Val Asn Tyr Asp  Asn Met Pro 
    1025                 1030                 1035             


Glu Val  Ala Glu Ser Leu Lys  Asp Ile Leu Glu Lys  Glu Ser Lys 
    1040                 1045                 1050             


Lys Leu  Thr Asn 
    1055         


<210>  1344
<211>  1057
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1344

Met Thr Ile Lys Glu Gln Ser His Phe Ala Ala Tyr Tyr Asn Met Ala 
1               5                   10                  15      


Arg His Asn Met Tyr Glu Thr Leu Cys Tyr Ile Ser Lys Ile Ser Gly 
            20                  25                  30          


Ile Gln Glu Gly Glu Asp Asn Lys Glu Ser Lys Ile Glu Asp Met Gln 
        35                  40                  45              


Leu Leu Arg Val Leu Thr Thr Lys Gly His Pro Glu Glu Lys Ile Arg 
    50                  55                  60                  


Ile Glu Lys Leu Ile Tyr Lys His Leu Pro Leu Phe Arg Pro Ala Val 
65                  70                  75                  80  


Glu Asp Leu Arg Lys Lys Ser Lys Glu Asn Val Lys Ser Pro Glu Leu 
                85                  90                  95      


Leu Ala Lys Val Ile Lys Asn Trp Ala Lys Val Ile Thr Tyr Tyr Arg 
            100                 105                 110         


Asp Lys Phe Thr His Tyr Val Phe Ile Asp Lys Arg His Glu Asn Lys 
        115                 120                 125             


Glu Phe Leu Asn Ala Glu Met Ser Val Ala Asn Asp Leu Asn Gln Ile 
    130                 135                 140                 


Phe Thr Ala Ser Ala Arg Val Ile Lys Glu Arg Phe Gly Leu Ser Thr 
145                 150                 155                 160 


Glu Leu Glu Phe Leu Thr Lys Gly Arg Tyr Arg Thr Gln Thr Ile Asp 
                165                 170                 175     


Gly Lys Arg Ser Thr Lys Leu Asn Pro Asn Phe Ile Tyr Ser Leu Gln 
            180                 185                 190         


Asp Lys Asn Glu Arg Leu Asn Lys Met Gly Leu Ile Phe Leu Ala Cys 
        195                 200                 205             


Gln Leu Ile Glu Lys Lys Tyr Ala Ser Met Leu Phe Asp Gln Gln Gly 
    210                 215                 220                 


Tyr Met Gly Arg Asp Ile Tyr Phe Asp Phe Thr Pro Ala Gln Cys Lys 
225                 230                 235                 240 


Tyr Ile Arg Glu Val Phe Ser Ala His Arg Ile Val Leu Pro Arg Gly 
                245                 250                 255     


Arg Met Asp Val Glu Arg Asn Glu Ile Thr Ile Ala Met Asp Met Phe 
            260                 265                 270         


Asn Glu Leu Gly Lys Cys Pro Lys Glu Leu Phe Glu Ile Ile Ser Lys 
        275                 280                 285             


Glu Glu Gln Lys Arg Phe Arg Thr Lys Ser Glu Thr Thr Gly Glu Glu 
    290                 295                 300                 


Val Leu Leu Met Arg His Ser Asp Arg Phe Ala Thr Leu Ala Leu Gln 
305                 310                 315                 320 


Tyr Ile Asp Asn Arg Lys Val Phe Glu Lys Ile Arg Phe Gln Leu Ser 
                325                 330                 335     


Leu Gly Lys Tyr Arg Tyr Lys Phe Tyr Asp Lys Thr Cys Val Asp Gly 
            340                 345                 350         


Asp Thr His Val Arg Ile Leu Gln Lys Glu Leu Asn Gly Phe Gly Arg 
        355                 360                 365             


Ile Asn Glu Ile Glu Leu Leu Lys Glu Glu Lys Trp Gly Gly Leu Ile 
    370                 375                 380                 


Arg Lys Phe Glu Asp Ala Lys Ile Asp Thr Ala Glu Thr Lys Pro Tyr 
385                 390                 395                 400 


Ile Thr Asp Gln Tyr Pro Gln Tyr Leu Phe Asn Gly Asn Arg Ile Gly 
                405                 410                 415     


Ile Tyr Phe Asn Ser Ala His Gly Lys Ala Met Arg Asn Gly Ala Tyr 
            420                 425                 430         


Ile Pro Asp Ile Glu Ser Gly Ala His Cys Ile Gln Pro Ile Cys Trp 
        435                 440                 445             


Ile Ser Asn Tyr Glu Leu Pro Ala Leu Ile Phe His His Ile Leu Thr 
    450                 455                 460                 


Lys Asp Glu Lys Lys Ser Leu Thr Glu Lys Ile Ile Ile Asp Cys Val 
465                 470                 475                 480 


Glu Arg Tyr Lys Lys Leu Phe Asn Asp Ile Ala Glu Gly Lys Val Ala 
                485                 490                 495     


Arg Thr Gly Asn Ala Thr Ser Asp Phe Glu Met Ile Ser Lys Glu Tyr 
            500                 505                 510         


Gly Ile Glu Lys Ser Asp Ile Pro Arg Glu Leu Gln Asp Tyr Phe Asn 
        515                 520                 525             


Gly Thr Glu Arg Asp Gly Ile Glu Gln Tyr Ala Lys Ala Gln Ile Arg 
    530                 535                 540                 


Glu Met Ile Glu Glu Asn Arg Ile Arg Leu Glu Gln Phe Asn Ser Lys 
545                 550                 555                 560 


Leu Lys Lys Ile Glu Asp Gly Glu Val Lys Tyr Gly Lys Arg Asp Tyr 
                565                 570                 575     


Thr Glu Ile Arg Thr Gly Glu Leu Ala Gln Tyr Leu Ala Lys Asp Ile 
            580                 585                 590         


Val Met Phe Met Pro Lys Ala Lys Tyr Lys Pro Thr Ser Lys Asn Tyr 
        595                 600                 605             


Asn Val Met Gln Ala Leu Leu Ala Thr Phe Asn Gly Ser Glu Ser Gly 
    610                 615                 620                 


Ser Thr Leu Asp Glu Val Asp Asp Met Phe Asp Asn Ile Lys Ala Cys 
625                 630                 635                 640 


Tyr Trp Lys Asn Glu Ser Asp Asn His Pro Phe Leu Glu Tyr Val Leu 
                645                 650                 655     


Gly Glu Glu Pro Lys Asp Ile Ile Ala Phe Tyr Lys Ile Tyr Leu Glu 
            660                 665                 670         


Leu Arg Gly Glu Tyr Leu Asp Lys Cys Ile Lys Lys Met Asp Leu Ala 
        675                 680                 685             


Thr Ile Pro Phe Ile His Thr Glu Arg Lys Arg Trp Glu Lys Arg Asp 
    690                 695                 700                 


Glu Lys Phe Phe Lys Glu Leu Ala Gln Arg Tyr Ala Thr Gln Pro Ile 
705                 710                 715                 720 


Glu Leu Pro Arg Gly Leu Tyr Asp Arg Ala Ile Lys Glu Tyr Leu Lys 
                725                 730                 735     


Ser Lys Ser Ile Leu Glu Asp Val Ile Ala Gln Glu Gln Cys Asn Val 
            740                 745                 750         


Thr Tyr Leu Ile Ala Arg Tyr Met Gln Asp Val Leu Lys Asp Asp Ser 
        755                 760                 765             


Gln Gln Phe Tyr Ser Leu Pro Arg His Tyr Ser Cys Leu Ser Glu Lys 
    770                 775                 780                 


Asp Lys Tyr Leu Ser Leu Thr Glu Arg Glu Ala Ile Ala Lys Ser Asp 
785                 790                 795                 800 


Ala Leu Asn Ser Phe Lys Lys Arg Glu Arg Glu Lys Glu Asn Glu Asn 
                805                 810                 815     


Arg Arg Gly Asn Arg Arg Tyr Asn Lys Gly Glu Asn Lys Asn Thr Ile 
            820                 825                 830         


Lys Asp Arg Asp Thr Glu Glu Lys Phe Asn Ser Leu Tyr Arg Lys Met 
        835                 840                 845             


Asp Asn Asn Glu Arg Ile Leu Arg Arg Tyr Lys Val Gln Asp Met Leu 
    850                 855                 860                 


Leu Tyr Leu Leu Ala Cys Asp Ile Ile Lys Gly Ile Met Arg Glu Asp 
865                 870                 875                 880 


Phe Gly Tyr Lys Leu Ser Met Ile Thr Asp Gly Lys Asn Ser Asn Phe 
                885                 890                 895     


Phe Asp Tyr Lys Met Pro Glu Phe Lys Thr Thr Ile Thr Leu Lys Glu 
            900                 905                 910         


Gly Lys Lys Phe Thr Ile Lys Gln Gln Tyr Leu Lys Ile Lys Asn Tyr 
        915                 920                 925             


Gly Asp Phe Leu Lys Phe Ile Phe Asp Leu Arg Ile Asp Ser Leu Leu 
    930                 935                 940                 


Ser Asn Gly Thr Lys Val Glu Ile Asp Arg Asn Ile Leu Glu Asp Glu 
945                 950                 955                 960 


Leu Ser Asn Tyr Asp Gly Ser Arg Pro Lys Val Phe Glu Thr Leu Leu 
                965                 970                 975     


Met Ile Glu Lys Ile Val Val Glu Lys His Lys Glu Leu Lys Asp Leu 
            980                 985                 990         


Glu His Ile Thr Phe Gly Asp Val  Leu Asn Val Ile Lys  Met Glu Glu 
        995                 1000                 1005             


Gly Glu  Lys Lys Ile Leu Arg  Leu Ile Arg Asn Ala  Phe Ser His 
    1010                 1015                 1020             


Asn Tyr  Tyr Pro Thr Ile Lys  Asp Val Asn Tyr Asp  Asn Met Pro 
    1025                 1030                 1035             


Glu Val  Ala Glu Ser Leu Lys  Asp Ile Leu Glu Lys  Glu Ser Lys 
    1040                 1045                 1050             


Lys Leu  Thr Asn 
    1055         


<210>  1345
<211>  1081
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1345

Met Gln Ala Gln Ser Leu Phe Asp Glu Tyr Lys His Leu Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Val Met Ser Ile Met Asn Ile Ile Thr Val Leu Asn His Ile 
            20                  25                  30          


His Gln Ile Ala Gly Leu Lys Arg Asn Glu Leu Gly Asp Asp Asp Asn 
        35                  40                  45              


Ile Tyr Ser His Pro Val Leu Lys Tyr Ile Ala Pro Glu Asn Asn Ser 
    50                  55                  60                  


Thr Thr Leu Pro Glu Lys Arg Asp Leu Ile Lys Glu Leu Leu Leu Glu 
65                  70                  75                  80  


Tyr Leu Pro Phe Leu Glu Ala Met Lys Asp Cys Tyr Lys Glu Val Lys 
                85                  90                  95      


Val Glu Lys Asp Lys Arg Asn Asn Lys Tyr Val Lys Asp Lys Lys Gln 
            100                 105                 110         


Val Phe Ile Arg Asn Tyr Ser Asp Ile Tyr Cys Ile Tyr Trp Thr Leu 
        115                 120                 125             


Tyr Asn Ile Phe Ser Thr Leu Ile Asn Tyr Arg Asp Lys Ser Cys His 
    130                 135                 140                 


Tyr Arg Phe Ile Pro Ser Lys Asp Gln Glu Glu Tyr Ser Lys Arg Thr 
145                 150                 155                 160 


Glu Tyr Asp Thr Val Arg Ile Ile Asn Lys Tyr Tyr Thr Tyr Ala Leu 
                165                 170                 175     


Arg Lys Thr Lys Glu Lys Tyr Gly Tyr Thr Thr Glu Gln Leu Ser Phe 
            180                 185                 190         


Ile Gln Asn Asn Arg Tyr Thr Asp Asp Lys Lys Val Asn Phe Asn Phe 
        195                 200                 205             


Phe Leu Ser Met Gln Ser Ser Asn Asn Asn Leu Ser His Val Gly Val 
    210                 215                 220                 


Ala Gln Leu Ile Cys Leu Phe Leu Gln Lys Lys Asp Val Asp Asn Phe 
225                 230                 235                 240 


Leu Glu Asn Leu Pro Ile Tyr Asp Asn Arg Tyr Cys Leu Gly Ile Asp 
                245                 250                 255     


Glu His Met Ile Ile Lys Arg Ser Leu Ala Leu His Ser Ile Lys Leu 
            260                 265                 270         


Pro Lys Glu Arg Leu Asn Ser Glu Lys Lys Asp Met Ala Ile Ala Met 
        275                 280                 285             


Asp Met Leu Asn Glu Leu Lys Arg Cys Pro Lys Glu Leu Phe Asn Thr 
    290                 295                 300                 


Leu Pro Phe Asp Lys Gln Glu Arg Phe Arg Ile Ile Ser Ser Asp His 
305                 310                 315                 320 


Lys Glu Val Leu Leu Met Arg Ser Thr Asp Arg Phe Val Pro Leu Ile 
                325                 330                 335     


Leu Gln Tyr Ile Asp Cys Asn Lys Lys Phe Lys Asp Ile Arg Phe His 
            340                 345                 350         


Val Asn Met Gly Lys Leu Arg Tyr Leu Phe Ser Pro Asn Lys Leu Cys 
        355                 360                 365             


Ile Asp Asn Gln Glu Arg Val Arg Met Leu Glu His Leu Leu Asn Gly 
    370                 375                 380                 


Tyr Gly Arg Ile Asp Glu Val Glu Tyr Leu Arg Lys Ala Pro Asn Gly 
385                 390                 395                 400 


Thr Phe Gly Asn Thr Asn Ile Pro Ile Lys Gly Phe Gly Glu Ile Glu 
                405                 410                 415     


Arg Asp Ser Ala Asp Ser Asn Asn Tyr Pro Tyr Ile Val Asp Thr His 
            420                 425                 430         


Thr His Tyr Ile Leu Asn Asn Asn Lys Val Glu Phe Cys Phe Cys Glu 
        435                 440                 445             


Asp Ser Lys Asn Lys Asn Val Phe Pro Thr Ile Glu Lys Glu Ile Asn 
    450                 455                 460                 


Gly Lys Trp Tyr Val Glu Lys Thr Ala Pro His Cys Arg Ile Ser Phe 
465                 470                 475                 480 


Phe Glu Ile Pro Ala Met Ala Phe His Met Phe Leu Cys Gly Ser Glu 
                485                 490                 495     


Lys Thr Glu Lys Leu Ile Lys Asp Val Tyr Asn Asn Tyr Ile Ser Leu 
            500                 505                 510         


Phe Asn Ala Leu Lys Asn Gly Ala Leu Thr Glu Glu Asn Tyr Lys Asp 
        515                 520                 525             


Phe Asn Ile Pro Glu Cys Asp Met Pro Lys Lys Ile Leu Asp Phe Leu 
    530                 535                 540                 


Lys Gly Lys Ala Glu Gly Lys Ser Ile Asp Gly Tyr Val Lys Asn Ile 
545                 550                 555                 560 


Leu Lys Lys Glu Leu Lys Asp Thr Arg Lys Arg Ile Glu Gln Ala Pro 
                565                 570                 575     


Ser Glu Lys Asp Gln Met Pro Ser Lys Arg Asn Lys Ile Gly Thr Lys 
            580                 585                 590         


Ser Tyr Lys Arg Val Leu Thr Gly Lys Leu Ala Asp Phe Leu Ala Lys 
        595                 600                 605             


Asp Ile Val Lys Tyr Gln Pro Thr Leu Cys Ala Gly Asp Asp Tyr Gly 
    610                 615                 620                 


Ile Asp Arg Met Thr Gly Met Asn Tyr Arg Ile Met Gln Ala Thr Ile 
625                 630                 635                 640 


Ala Thr Tyr Asn Asp Asp Asp Asp Phe Asp Thr Phe Tyr Asn Val Phe 
                645                 650                 655     


Lys Met Ala Gly Leu Val Asp Gly Asp Glu Arg Lys Asn His Pro Phe 
            660                 665                 670         


Leu Lys Lys Val Leu Leu Ser Lys Pro Gln Asn Thr Val Ala Phe Asn 
        675                 680                 685             


Ile Lys Tyr Leu Lys Glu Lys Glu Ile Tyr Leu Arg Asn Ile Glu Lys 
    690                 695                 700                 


Lys Asn Ile Ile Pro Pro Phe Val Asn Arg Glu Arg Asn Lys Trp Cys 
705                 710                 715                 720 


Glu Arg Asp Cys Glu Tyr Tyr Arg Ile Leu Gly Glu Asn Leu Leu Asp 
                725                 730                 735     


Leu Pro Ile Glu Leu Pro Arg Gln Met Phe Tyr Lys Asp Ile Arg Ala 
            740                 745                 750         


Gln Leu Glu Pro Leu Met Pro Glu Ile Asp Phe Ser Gln Thr Asn Thr 
        755                 760                 765             


Thr Tyr Leu Ile Ala Glu Tyr Leu Lys Arg Val Arg Gly Asp Asp Phe 
    770                 775                 780                 


Gln Glu Phe Tyr Ser Trp Glu Arg Asn Tyr Arg Tyr Ile Asp Phe Leu 
785                 790                 795                 800 


Lys Cys Ile Arg Asp Asp Asn Gly Arg Ile Cys Ala Gln Tyr Thr Thr 
                805                 810                 815     


Thr Glu Glu Arg Glu Ser Leu Trp Glu Asp Ser Lys Asn Arg Thr Ala 
            820                 825                 830         


Glu Tyr Lys Arg Ser Glu Glu Gln Lys Asn Glu Lys Lys Asp Lys Asn 
        835                 840                 845             


Phe Glu Asp Ser Leu Glu Glu Arg Ile Ser Ser Ser His Ile Lys Phe 
    850                 855                 860                 


Gln Asn Thr Glu Lys His Ile Arg Arg Tyr Lys Val Gln Asp Ala Leu 
865                 870                 875                 880 


Leu Phe Met Ile Ala Glu Lys Gln Phe Gly Lys Tyr Leu Asp Asp Ile 
                885                 890                 895     


Lys Ala Lys Asn Phe Lys Leu Lys Asp Ile Met Pro Asp Thr Asp Lys 
            900                 905                 910         


Gly Ile Leu Ser Glu Thr Met Pro Ile Asp Phe Thr Phe Thr Lys Lys 
        915                 920                 925             


Asn Ile Lys Tyr Asn Ile His Ala Lys Asn Leu Lys Phe Lys Glu Tyr 
    930                 935                 940                 


Gly Asp Leu Phe Ile Leu Ala Asn Asp Lys Arg Leu Glu Ser Leu Trp 
945                 950                 955                 960 


Lys Ile Leu Ala Thr Asp Thr Val Asn Lys Glu Glu Ile Ser Glu Glu 
                965                 970                 975     


Phe Ala Lys Tyr Asp Phe Cys Arg Pro Asp Ile Thr Lys Leu Val Leu 
            980                 985                 990         


Asp Phe Glu Lys Asp Val Leu Glu  Lys Tyr Pro Glu Ile  Ile Glu Glu 
        995                 1000                 1005             


Ala Glu  Lys Glu Tyr Lys Lys  Phe Asp Phe Lys Phe  Ile Leu Asp 
    1010                 1015                 1020             


Trp Leu  Ile Asn Lys Lys Lys  Leu Asn Tyr Gly Ile  Arg Asn Lys 
    1025                 1030                 1035             


Leu Leu  Leu Ile Arg Asn Ala  Phe Asn His Asn Ser  Tyr Pro Asp 
    1040                 1045                 1050             


Lys Lys  Tyr Ala Glu Val Arg  Glu Leu Pro Glu Ile  Ala Thr Asn 
    1055                 1060                 1065             


Leu Lys  Lys Thr Phe Asp Glu  Asn Ala Lys Lys Tyr  Glu 
    1070                 1075                 1080     


<210>  1346
<211>  1081
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1346

Met Gln Ala Gln Ser Leu Phe Asp Glu Tyr Lys His Leu Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Val Met Ser Ile Met Asn Ile Ile Thr Val Leu Asn His Ile 
            20                  25                  30          


His Gln Ile Ala Gly Leu Lys Arg Asn Glu Leu Gly Asp Asp Asp Asn 
        35                  40                  45              


Ile Tyr Ser His Pro Val Leu Lys Tyr Ile Ala Pro Glu Asn Asn Ser 
    50                  55                  60                  


Thr Thr Leu Pro Glu Lys Arg Asp Leu Ile Lys Glu Leu Leu Leu Glu 
65                  70                  75                  80  


Tyr Leu Pro Phe Leu Glu Ala Met Lys Asp Cys Tyr Lys Glu Val Lys 
                85                  90                  95      


Val Glu Lys Asp Lys Arg Asn Asn Lys Tyr Val Lys Asp Lys Lys Gln 
            100                 105                 110         


Val Phe Ile Arg Asn Tyr Ser Asp Ile Tyr Cys Ile Tyr Trp Thr Leu 
        115                 120                 125             


Tyr Asn Ile Phe Ser Thr Leu Ile Asn Tyr Arg Asp Lys Ser Cys His 
    130                 135                 140                 


Tyr Arg Phe Ile Pro Ser Lys Asp Gln Glu Glu Tyr Ser Lys Arg Thr 
145                 150                 155                 160 


Glu Tyr Asp Thr Val Arg Ile Ile Asn Lys Tyr Tyr Thr Tyr Ala Leu 
                165                 170                 175     


Arg Lys Thr Lys Glu Lys Tyr Gly Tyr Thr Thr Glu Gln Leu Ser Phe 
            180                 185                 190         


Ile Gln Asn Asn Arg Tyr Thr Asp Asp Lys Lys Val Asn Phe Asn Phe 
        195                 200                 205             


Phe Leu Ser Met Gln Ser Ser Asn Asn Asn Leu Ser His Val Gly Val 
    210                 215                 220                 


Ala Gln Leu Ile Cys Leu Phe Leu Gln Lys Lys Asp Val Asp Asn Phe 
225                 230                 235                 240 


Leu Glu Asn Leu Pro Ile Tyr Asp Asn Arg Tyr Cys Leu Gly Ile Asp 
                245                 250                 255     


Glu His Met Ile Ile Lys Arg Ser Leu Ala Leu His Ser Ile Lys Leu 
            260                 265                 270         


Pro Lys Glu Arg Leu Asn Ser Glu Lys Lys Asp Met Ala Ile Ala Met 
        275                 280                 285             


Asp Met Leu Asn Glu Leu Lys Arg Cys Pro Lys Glu Leu Phe Asn Thr 
    290                 295                 300                 


Leu Pro Phe Asp Lys Gln Glu Arg Phe Arg Ile Ile Ser Ser Asp His 
305                 310                 315                 320 


Lys Glu Val Leu Leu Met Arg Ser Thr Asp Arg Phe Val Pro Leu Ile 
                325                 330                 335     


Leu Gln Tyr Ile Asp Cys Asn Lys Lys Phe Lys Asp Ile Arg Phe His 
            340                 345                 350         


Val Asn Met Gly Lys Leu Arg Tyr Leu Phe Ser Pro Asn Lys Leu Cys 
        355                 360                 365             


Ile Asp Asn Gln Glu Arg Val Arg Met Leu Glu His Leu Leu Asn Gly 
    370                 375                 380                 


Tyr Gly Arg Ile Asp Glu Val Glu Tyr Leu Arg Lys Ala Pro Asn Gly 
385                 390                 395                 400 


Thr Phe Gly Asn Thr Asn Ile Pro Ile Lys Gly Phe Gly Glu Ile Glu 
                405                 410                 415     


Arg Asp Ser Ala Asp Ser Asn Asn Tyr Pro Tyr Ile Val Asp Thr His 
            420                 425                 430         


Thr His Tyr Ile Leu Asn Asn Asn Lys Val Glu Phe Cys Phe Cys Glu 
        435                 440                 445             


Asp Ser Lys Asn Lys Asn Val Phe Pro Thr Ile Glu Lys Glu Ile Asn 
    450                 455                 460                 


Gly Lys Trp Tyr Val Glu Lys Thr Ala Pro His Cys Arg Ile Ser Phe 
465                 470                 475                 480 


Phe Glu Ile Pro Ala Met Ala Phe His Met Phe Leu Cys Gly Ser Glu 
                485                 490                 495     


Lys Thr Glu Lys Leu Ile Lys Asp Val Tyr Asn Asn Tyr Ile Ser Leu 
            500                 505                 510         


Phe Asn Ala Leu Lys Asn Gly Ala Leu Thr Glu Glu Asn Tyr Lys Asp 
        515                 520                 525             


Phe Asn Ile Pro Glu Cys Asp Met Pro Lys Lys Ile Leu Asp Phe Leu 
    530                 535                 540                 


Lys Gly Lys Ala Glu Gly Lys Ser Ile Asp Gly Tyr Val Lys Asn Ile 
545                 550                 555                 560 


Leu Lys Lys Glu Leu Lys Asp Thr Arg Lys Arg Ile Glu Gln Ala Pro 
                565                 570                 575     


Ser Glu Lys Asp Gln Met Pro Ser Lys Arg Asn Lys Ile Gly Thr Lys 
            580                 585                 590         


Ser Tyr Lys Arg Val Leu Thr Gly Lys Leu Ala Asp Phe Leu Ala Lys 
        595                 600                 605             


Asp Ile Val Lys Tyr Gln Pro Thr Leu Cys Ala Gly Asp Asp Tyr Gly 
    610                 615                 620                 


Ile Asp Arg Met Thr Gly Met Asn Tyr Arg Ile Met Gln Ala Thr Ile 
625                 630                 635                 640 


Ala Thr Tyr Asn Asp Asp Asp Asp Phe Asp Thr Phe Tyr Asn Val Phe 
                645                 650                 655     


Lys Met Ala Gly Leu Val Asp Gly Asp Glu Arg Lys Asn His Pro Phe 
            660                 665                 670         


Leu Lys Lys Val Leu Leu Ser Lys Pro Gln Asn Thr Val Ala Phe Asn 
        675                 680                 685             


Ile Lys Tyr Leu Lys Glu Lys Glu Ile Tyr Leu Arg Asn Ile Glu Lys 
    690                 695                 700                 


Lys Asn Ile Ile Pro Pro Phe Val Asn Arg Glu Arg Asn Lys Trp Cys 
705                 710                 715                 720 


Glu Arg Asp Cys Glu Tyr Tyr Arg Ile Leu Gly Glu Asn Leu Leu Asp 
                725                 730                 735     


Leu Pro Ile Glu Leu Pro Arg Gln Met Phe Tyr Lys Asp Ile Arg Ala 
            740                 745                 750         


Gln Leu Glu Pro Leu Met Pro Glu Ile Asp Phe Ser Gln Thr Asn Thr 
        755                 760                 765             


Thr Tyr Leu Ile Ala Glu Tyr Leu Lys Arg Val Arg Gly Asp Asp Phe 
    770                 775                 780                 


Gln Glu Phe Tyr Ser Trp Glu Arg Asn Tyr Arg Tyr Ile Asp Phe Leu 
785                 790                 795                 800 


Lys Cys Ile Arg Asp Asp Asn Gly Arg Ile Cys Ala Gln Tyr Thr Thr 
                805                 810                 815     


Thr Glu Glu Arg Glu Ser Leu Trp Glu Asp Ser Lys Asn Arg Thr Ala 
            820                 825                 830         


Glu Tyr Lys Arg Ser Glu Glu Gln Lys Asn Glu Lys Lys Asp Lys Asn 
        835                 840                 845             


Phe Glu Asp Ser Leu Glu Glu Arg Ile Ser Ser Ser His Ile Lys Phe 
    850                 855                 860                 


Gln Asn Thr Glu Lys His Ile Arg Arg Tyr Lys Val Gln Asp Ala Leu 
865                 870                 875                 880 


Leu Phe Met Ile Ala Glu Lys Gln Phe Gly Lys Tyr Leu Asp Asp Ile 
                885                 890                 895     


Lys Ala Lys Asn Phe Lys Leu Lys Asp Ile Met Pro Asp Thr Asp Lys 
            900                 905                 910         


Gly Ile Leu Ser Glu Thr Met Pro Ile Asp Phe Thr Phe Thr Lys Lys 
        915                 920                 925             


Asn Ile Lys Tyr Asn Ile His Ala Lys Asn Leu Lys Phe Lys Glu Tyr 
    930                 935                 940                 


Gly Asp Leu Phe Ile Leu Ala Asn Asp Lys Arg Leu Glu Ser Leu Trp 
945                 950                 955                 960 


Lys Ile Leu Ala Thr Asp Thr Val Asn Lys Glu Glu Ile Ser Glu Glu 
                965                 970                 975     


Phe Ala Lys Tyr Asp Phe Cys Arg Pro Asp Ile Thr Lys Leu Val Leu 
            980                 985                 990         


Asp Phe Glu Lys Asp Val Leu Glu  Lys Tyr Pro Glu Ile  Ile Glu Glu 
        995                 1000                 1005             


Ala Glu  Lys Glu Tyr Lys Lys  Phe Asp Phe Lys Phe  Ile Leu Asp 
    1010                 1015                 1020             


Trp Leu  Ile Asn Lys Lys Lys  Leu Asn Tyr Gly Ile  Arg Asn Lys 
    1025                 1030                 1035             


Leu Leu  Leu Ile Arg Asn Ala  Phe Asn His Asn Ser  Tyr Pro Asp 
    1040                 1045                 1050             


Lys Lys  Tyr Ala Glu Val Arg  Glu Leu Pro Glu Ile  Ala Thr Asn 
    1055                 1060                 1065             


Leu Lys  Lys Thr Phe Asp Glu  Asn Ala Lys Lys Tyr  Glu 
    1070                 1075                 1080     


<210>  1347
<211>  1253
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1347

Met Leu Glu Ile Gln Ile Glu Lys Glu Lys Arg Gly Trp Phe Trp Ala 
1               5                   10                  15      


Met Asn Leu Thr Met Ala Leu Asn Asn Leu Glu Thr Ile Ala Lys Arg 
            20                  25                  30          


Ala Leu Asn Val Leu Gly Lys Pro Tyr Pro Ala Ser Gln Ser Glu Asp 
        35                  40                  45              


Glu Gln Thr Asn Ala Leu Lys Gln Ala Leu Asp Glu Leu Gln Lys Gln 
    50                  55                  60                  


Pro Leu Ile Cys Gln Thr Lys Ile Glu Arg Val Phe Phe Arg Ser Leu 
65                  70                  75                  80  


Pro His Leu Asn Lys Phe Arg Gln Phe Ile Glu Met Gly Gly Glu Lys 
                85                  90                  95      


Ser Ser Ala Ser Tyr Val Glu Lys Ser Ser Ser Arg Ala Asp Ala Glu 
            100                 105                 110         


Ala Thr Gln Arg Gln Ser Gly Arg Asp Phe Thr Ser Asp Asp Leu Phe 
        115                 120                 125             


Gln Leu Ala Arg Tyr Tyr Leu Lys Ser Leu Val Glu Leu Arg Asn Tyr 
    130                 135                 140                 


Phe Ala His Ser Glu His Gln Tyr Pro Lys Leu Pro Glu Ser Leu Asp 
145                 150                 155                 160 


Ile Lys Gly Val Arg Phe Pro Ser Ser Phe Glu Asn Ala Leu Phe Asn 
                165                 170                 175     


Ala Asn Val Arg Thr Val Lys Asp Arg Phe Tyr Lys Asp Asp Arg Lys 
            180                 185                 190         


Asp Ala Arg Glu Ile Glu Asn Gly Phe Leu Cys Phe Arg Pro Lys Lys 
        195                 200                 205             


Thr Val Lys Asn Arg Glu Thr Val Asp Asn Pro Glu Phe Lys Phe Arg 
    210                 215                 220                 


Leu Thr Glu Arg Asn Asp Ala Asn Gly Arg Arg Tyr Pro Thr Gln Ala 
225                 230                 235                 240 


Gly Leu Ala Phe Phe Val Ala Arg Phe Leu Glu Lys Arg Tyr Val Asp 
                245                 250                 255     


Leu Leu Phe Glu Thr Thr Asp Ala Asn Gly Val Pro Val Leu Pro Leu 
            260                 265                 270         


His Arg Pro Gln Asp Val Asp Gly Val Glu Phe Ser Leu Ala Pro Arg 
        275                 280                 285             


Arg Val Tyr Gly Leu Asn Ala Ala Arg Leu Pro Arg Arg Arg Val Glu 
    290                 295                 300                 


Thr Thr Ala Arg Pro Glu Ser Ser Asn Glu Thr Leu Gly Leu Asp Leu 
305                 310                 315                 320 


Ile Gly Tyr Leu Ala Arg Cys Pro Lys Arg Val Tyr Glu Phe Leu Ser 
                325                 330                 335     


Glu Thr Asp Arg Arg Lys Phe Arg Val Ala Ala Asp Glu Ser Asn Pro 
            340                 345                 350         


Ser Glu Gly Leu Arg Thr Arg Ser Glu Lys Arg Phe Ala Arg Leu Ala 
        355                 360                 365             


Ala Leu Cys Leu Asp Arg Met Asn Cys Phe Glu Asn Leu Arg Phe Gln 
    370                 375                 380                 


Val Asp Met Gly Gln Tyr Tyr Ser Ala Thr His Arg Arg Arg Leu Ile 
385                 390                 395                 400 


Asp Gly Thr Thr Ile Asp Asp Arg Arg Val Gly Lys Arg Val Phe Trp 
                405                 410                 415     


Phe Glu Arg Ile Gln Asn Ala Val Asp Tyr Tyr Arg Ala Glu Arg Leu 
            420                 425                 430         


Lys Pro Glu Ser Lys Tyr Phe Val Pro Thr Asp Glu Ala Glu Thr Pro 
        435                 440                 445             


Pro Glu Thr Asp Tyr Arg Val Asp Ala Tyr Pro Arg Tyr Arg Val Lys 
    450                 455                 460                 


Asn Gln Gln Leu Gly Leu Arg Leu Val Asp Ala Ser Gln Lys Asn Ala 
465                 470                 475                 480 


Pro Pro Lys Leu Ile Pro Trp Thr His Ser Ala Lys Arg Gly Ser Ala 
                485                 490                 495     


Pro Lys Thr Arg Met Lys Arg Pro Glu Phe Trp Leu Ser Gln Tyr Glu 
            500                 505                 510         


Leu Pro Ala Leu Leu Phe Val Ala Leu His Gly Lys Ala Gln Asp Ala 
        515                 520                 525             


Gln Asn Val Ile Ala Asp Tyr Gln Lys Asn Trp Arg Arg Phe Leu Glu 
    530                 535                 540                 


Asp Val Arg Asp Gly Lys Phe Asp Phe Gly Gly Gly Arg Ala Leu Arg 
545                 550                 555                 560 


Glu Thr Arg Gln Thr Phe Glu Ser Gln Tyr Gly Leu Arg Phe Asp Asp 
                565                 570                 575     


Leu Pro Asp Ser Thr Arg Ala Leu Phe Arg Ser Thr Ala Ser Asp Ser 
            580                 585                 590         


Lys Glu Leu Glu Lys Lys Arg Val Asp Ala Ala Glu Gln Thr Leu Pro 
        595                 600                 605             


Glu Arg Gln Ile Asp Arg Leu Leu Asp Glu Thr Arg Arg Arg Leu Ala 
    610                 615                 620                 


Val Leu Glu Ser Glu Thr Arg Glu Val Phe Gln Leu Gly Lys Arg Lys 
625                 630                 635                 640 


Arg Pro Ser Leu Ser Val Gly Arg Val Ala Ser Cys Leu Val Arg Asp 
                645                 650                 655     


Leu Met Arg Phe Gln Tyr Ala Thr Ser Glu Lys Ser Phe Gly Lys Ile 
            660                 665                 670         


Pro Ser Ser Pro Asp Phe Ile Ala Leu Gln Thr Ser Leu Ala Cys Phe 
        675                 680                 685             


Glu Ser Arg Gln Asn Glu Leu Leu Glu Ile Phe Lys Ala Ala Lys Leu 
    690                 695                 700                 


Ile Pro Ser Asn Phe Val Ala Pro Asn Asp Ala Glu Glu Ala Phe Phe 
705                 710                 715                 720 


Phe Ala Asp Ala Gln Asn Ala Glu Arg Ser Leu His Pro Phe Leu Gly 
                725                 730                 735     


Ala Val Val Ala Asp Ala Ala Asn Leu Arg Asp Trp Lys Ser Phe Tyr 
            740                 745                 750         


Arg Ala Tyr Leu Thr Cys Arg Leu Asn Trp Leu Arg Gly Cys Ala Pro 
        755                 760                 765             


Gln Glu Leu Arg His Thr Arg Tyr Gly Asn Arg Arg Leu Glu Lys Leu 
    770                 775                 780                 


Lys Lys Met Arg Lys Ser Gly Lys Arg Gln Thr Val Ala Gln Gln Met 
785                 790                 795                 800 


Ala Thr Arg Leu Leu Glu Gln Pro Ile Asn Leu Pro Arg Gly Leu Phe 
                805                 810                 815     


Thr Asp Leu Val Arg Ala Val Val Gln Glu Arg Phe Gly Asp Gln Leu 
            820                 825                 830         


Ala Lys Ala Thr Gln Asn Gly Ala Thr Ser Thr Asn Ala Ser Trp Leu 
        835                 840                 845             


Ile Gly Lys Val Arg Asp Trp Ser Asp Asp Ala Ser Gln Gly Phe Tyr 
    850                 855                 860                 


Ser Trp Arg Arg Asp Tyr Arg Asn Val Ala Ser Phe Lys Arg Leu Phe 
865                 870                 875                 880 


Glu Leu Cys Gly Pro Thr Val Ser Thr Ser Pro Leu Ala Phe Arg Ala 
                885                 890                 895     


Leu Asn Ser Thr Ser Pro Leu Asp Phe Arg Ala Leu Lys Glu Ala Phe 
            900                 905                 910         


Asp Ala Asn Phe Asp Ala Asn Tyr Ala Ala Ala Glu Phe Ala Lys Thr 
        915                 920                 925             


Asp His Lys Thr Asp Arg Glu Asp Trp Glu Arg Phe Ile Arg Glu Ala 
    930                 935                 940                 


Glu Ala Glu Leu Arg Glu Glu Ala Leu Glu Ala Thr Arg Gly Arg Ser 
945                 950                 955                 960 


Gln Arg Arg Pro Phe Ile Pro Arg Glu Lys Ile Glu Glu Arg Ala Ser 
                965                 970                 975     


Lys Lys Arg Lys Lys Phe Ala Asp Glu Gln Lys Ala Lys Arg Arg Ala 
            980                 985                 990         


Ala Glu His Ala Lys Ile Arg Arg  Leu Ser Asp Ala Glu  Arg Asp Ile 
        995                 1000                 1005             


Arg His  Ala Glu Ile Gln Asp  Tyr Val Leu Leu Leu  Ala Ala Ser 
    1010                 1015                 1020             


Tyr Phe  Leu Phe Glu Gly Asp  Leu Ala Lys Ile Arg  Leu Ala Asp 
    1025                 1030                 1035             


Val Tyr  Ala Ile Val Asp Asp  Ala Thr Gly Thr Val  Ser Thr Asn 
    1040                 1045                 1050             


Pro Leu  Arg Lys Leu Arg Pro  Cys Glu Val Leu Val  Asp Val Pro 
    1055                 1060                 1065             


Gly Ser  Gly Thr Cys Lys Ile  Arg Gly Glu Met Asn  Val Lys Asn 
    1070                 1075                 1080             


Ser Gly  Asn Phe Gln Arg Phe  Leu Thr Asp Gly Arg  Leu Pro Ser 
    1085                 1090                 1095             


Phe Leu  Arg Ser Leu Arg Leu  Met Gln Ala Glu Asn  Ala Glu Glu 
    1100                 1105                 1110             


Leu Ser  Tyr Ile Asp Leu Ala  Asn Glu Phe Ala Ala  Ser Asp Arg 
    1115                 1120                 1125             


Leu Gln  Arg Gly Arg Ile Phe  Ala Ala Ile Tyr Arg  Phe Glu Asn 
    1130                 1135                 1140             


Ala Cys  Phe Ser Val Phe Pro  Glu Leu Lys Asp Lys  Lys Arg Gly 
    1145                 1150                 1155             


Gly Tyr  Val Ser Phe Ala Thr  Ile Leu Thr Ser Val  Phe Pro Asn 
    1160                 1165                 1170             


Asp Glu  Glu Thr Gln Tyr Arg  Leu Leu Val Ile Arg  Asn Lys Phe 
    1175                 1180                 1185             


Met His  Gln Glu Tyr Pro Ile  Tyr Asp Ala Ser Gln  Thr Lys Asp 
    1190                 1195                 1200             


Lys Gln  Arg Trp Thr Pro Ile  Phe Asp Arg Trp Asn  Arg Glu Met 
    1205                 1210                 1215             


Trp Ala  Lys Tyr Asp Pro Lys  His Gly Arg Ala Leu  Cys Gln Cys 
    1220                 1225                 1230             


Ala Val  Asp Trp Ala Glu Pro  Tyr Phe Asp Glu Ala  Thr Lys Leu 
    1235                 1240                 1245             


Val Glu  Ser Arg Arg 
    1250             


<210>  1348
<211>  1138
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1348

Met Glu Thr Gln Glu Asn Glu Leu Phe Glu Asn Arg Arg Arg Thr Leu 
1               5                   10                  15      


Ala Asp Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Leu Ala Arg Leu 
            20                  25                  30          


Asn Ile Phe Ser Ile Asn Asn Tyr Leu Ala Lys Glu Phe Gln Gln Thr 
        35                  40                  45              


Glu Leu Lys Asp Asp Glu Leu Ile Gln Asn Gly Phe Ile Cys Ile Pro 
    50                  55                  60                  


Ser Gln Lys Asn Arg Asn Asp Asn Lys Leu Phe Glu Arg Leu Ile Arg 
65                  70                  75                  80  


Leu Met Pro Val Ile Lys Gln Phe Asp Ala Ala Arg Leu Pro Glu Asp 
                85                  90                  95      


Glu Gln Gln Ser Gly Gln Ala Glu Gly Lys Asp Ile Lys Ala Met Ala 
            100                 105                 110         


Lys Thr Leu Lys Ala Leu Phe Lys Asp Met Gln Glu Phe Arg Asn Asp 
        115                 120                 125             


Tyr Thr His Phe Tyr Ala Thr Asp Lys Gln Glu Cys Arg Lys Leu Thr 
    130                 135                 140                 


Val Leu Pro Glu Thr Ala Thr Phe Leu Lys Ala Ser Phe Ala Arg Ala 
145                 150                 155                 160 


Ile Glu Tyr Ser Lys Ser Arg Phe Lys Asp Val Leu Ser Glu Asp Asp 
                165                 170                 175     


Tyr Ser Ile Val Ala Gly Lys Glu Leu Val Ser Asp Asp Asn Thr Ile 
            180                 185                 190         


Thr Thr Glu Gly Leu Val Phe Leu Thr Ser Leu Phe Leu Asp Arg Glu 
        195                 200                 205             


Asn Ala Phe Gln Phe Ile Gly Lys Val Gln Gly Leu Lys Gly Thr Gln 
    210                 215                 220                 


Phe Lys Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ala Tyr Cys Val 
225                 230                 235                 240 


Arg Leu Pro His Asp Lys Leu Ile Ser Asp Asn Pro Ile Gln Ala Leu 
                245                 250                 255     


Leu Phe Asp Met Leu Asn Glu Leu Asn Lys Cys Pro Lys Lys Leu Tyr 
            260                 265                 270         


Asn Val Leu Ser Glu Glu Val Lys Lys Glu Phe Arg Pro Glu Leu Ser 
        275                 280                 285             


Glu Ser Gly Ile Glu Asn Met Leu Ala Asn Ser Phe Asn Asp Glu Glu 
    290                 295                 300                 


Arg Glu Lys Leu Leu Asp Glu Ile Glu Tyr Lys Glu Tyr Ile Glu Gln 
305                 310                 315                 320 


Leu Thr Ile Arg Val Arg His Ser Asn Arg Phe His Tyr Phe Ala Met 
                325                 330                 335     


Arg Phe Ile Asp Glu Gln Glu Leu Trp Pro Gly Ile Arg Phe Gln Ile 
            340                 345                 350         


Asp Leu Gly Lys Tyr Thr Leu Thr Gln Tyr Asp Lys Gln Val Leu Gly 
        355                 360                 365             


Glu Ser Ile Pro Arg Ser Val Val Glu Asn Thr Arg Ala Phe Gly Arg 
    370                 375                 380                 


Leu Ser Asn Phe Leu Thr Ala Asp Pro Asp Ser Leu Glu Gln Arg Ile 
385                 390                 395                 400 


Asp Val Asp His Arg Ala Asn Gly Phe Glu Gln Phe Ala Pro His Tyr 
                405                 410                 415     


Asn Ala Asp Ile Asn Lys Ile Gly Ile Ala Phe Thr Glu Lys Glu Gln 
            420                 425                 430         


Leu Pro Tyr Ile Val Arg Thr Lys Asn Ala Glu Thr Asn Arg Val Lys 
        435                 440                 445             


Tyr Ser Phe Lys Gln Pro Gln Pro Asp Ala Phe Ile Ser Leu His Glu 
    450                 455                 460                 


Leu Ala Lys Ala Ile Leu Leu Glu Gln Leu Gln Pro Gly Glu Ser Glu 
465                 470                 475                 480 


Lys Leu Ile Arg Ala Phe Cys Ser Thr Ala Glu Asn Lys Leu Phe Asn 
                485                 490                 495     


Pro Glu Phe Ile Glu Ser Ile Lys Trp Lys Leu Pro Asp Trp Lys Pro 
            500                 505                 510         


Phe Gln Lys Gln Cys Asp Thr Lys Lys Ser Arg Ala Tyr Ile Thr Lys 
        515                 520                 525             


Arg Asn Met Phe Ala Tyr Ala Pro Arg Asp Arg Lys Lys Leu Leu Asp 
    530                 535                 540                 


Glu Leu Leu Ala Pro Tyr Gly Leu Asn Arg Lys Gln Val Pro Glu Arg 
545                 550                 555                 560 


Ile Leu Asn Tyr Trp Leu Asn Ile Glu Glu Val His Asp Ala Arg Ser 
                565                 570                 575     


Val Asn Glu Arg Leu Leu Leu Met Lys Arg Asp Gly Leu Gln Arg Leu 
            580                 585                 590         


Lys Gln Leu Glu Lys His Arg Lys Asp Pro Ser Ile Arg Ile Pro Lys 
        595                 600                 605             


Val Gly Glu Met Ala Thr Phe Leu Ala Arg Asp Ile Val Asp Met Met 
    610                 615                 620                 


Ile Asp Gly Thr Lys Lys Lys Lys Ile Thr Ser Ile Tyr Tyr Asp Lys 
625                 630                 635                 640 


Met Gln Glu Cys Leu Ala Phe Tyr Ala Asp Ala Glu Lys Lys Gln Gln 
                645                 650                 655     


Phe Ile Asp Leu Val Cys Glu Leu Asp Leu Asn Asp Met Gly Gly His 
            660                 665                 670         


Pro Phe Leu Lys Asn Leu Asn Leu Glu Ser Ile Gly Lys Thr Ser Glu 
        675                 680                 685             


Phe Tyr Ser Arg Tyr Leu Glu Ala Lys Val Gln Lys Asp Val Ser Glu 
    690                 695                 700                 


Tyr Asn Tyr Lys Lys Cys Arg Glu Val Thr Lys Asn Val Ser Trp Met 
705                 710                 715                 720 


Val Lys Thr Phe Glu Thr Lys Val Trp Asn Glu Glu Ile Lys Lys Asn 
                725                 730                 735     


Leu Thr Glu Tyr Arg Ile Pro Ala Asp Lys Arg Asn Ile Pro Tyr Ser 
            740                 745                 750         


Ile Leu Gln Trp Glu Lys Glu Ala Ser Thr Leu Glu Glu Trp Leu His 
        755                 760                 765             


Ala Ile Asn His Gly Lys Gln Glu Gly Asp Arg Lys Arg Pro Ile Asp 
    770                 775                 780                 


Leu Pro Thr Asp Leu Phe Asp Ala Arg Leu Cys Glu Leu Met Lys Ala 
785                 790                 795                 800 


Gln Leu Gln Glu Lys Gly Gln Ser Pro Thr Glu Thr Ala Lys Tyr Asn 
                805                 810                 815     


Glu Leu Leu Lys Gln Trp Trp Ser Leu Arg Glu Asp Glu Thr Gln Pro 
            820                 825                 830         


Phe Tyr Asn Gly Ala Arg His Tyr Val Ile Lys Glu Glu Ala Val Cys 
        835                 840                 845             


Phe Thr Pro Gly Ala Gln Pro Arg Leu Thr Ser Cys Tyr Ala Asp Ala 
    850                 855                 860                 


Val Glu Glu Ala Tyr Asn Arg Leu Ser Ala Glu Arg Asn Ile Ala Arg 
865                 870                 875                 880 


Arg Asn Asp Lys Arg Leu Pro Pro Ile Gln Lys Gln Glu Met Glu Lys 
                885                 890                 895     


Thr Phe Lys Arg Ala Leu Tyr Asp Thr Glu Lys Glu Ile Arg Leu Leu 
            900                 905                 910         


Gly Glu Gln Asp Arg Ile Leu Leu Leu Met Ala Glu Gln Leu Ser Pro 
        915                 920                 925             


Gly Lys Glu Thr Leu Lys Leu Lys Thr Val Ala Gln Glu Leu Thr Arg 
    930                 935                 940                 


Ser Arg Glu Ile Lys Lys Glu Phe Ser Tyr Ile Ser Asn Tyr Asn Thr 
945                 950                 955                 960 


Gln Gly Glu Arg Leu Lys Lys Glu Glu Val Pro Pro Gln Leu Thr Leu 
                965                 970                 975     


Thr Val Thr Gly Ile Met Gln Leu Lys Asn Ser Asn Asp Leu Asn Arg 
            980                 985                 990         


Phe Ala His Asp Arg Arg Met Pro  Glu Leu Val Ala Tyr  Leu Pro Asn 
        995                 1000                 1005             


Ala Thr  Val Asp Ala Asp Lys  Leu Arg Tyr Glu Leu  Met Asp Tyr 
    1010                 1015                 1020             


Asn Lys  Ala Arg Leu Thr Val  Phe Asp Ala Val Phe  Lys Leu Glu 
    1025                 1030                 1035             


Lys Ala  Leu Ile Asp Gln Asp  Arg Glu Gly Val Ile  Thr Leu Phe 
    1040                 1045                 1050             


Thr Asp  Glu Gln Gly Glu Ala  Lys Gln Ser Arg Met  Gln His Lys 
    1055                 1060                 1065             


Pro Tyr  Leu Gln Trp Leu Leu  Asn Lys Gly Val Ile  Thr Gln Pro 
    1070                 1075                 1080             


Glu Ser  Cys Tyr Leu Asn Met  Leu Arg Asn Ser Phe  Ser His Asn 
    1085                 1090                 1095             


Gln Phe  Pro His Ile Ala Val  Ala Leu Asn Gly Thr  Glu Val Val 
    1100                 1105                 1110             


Pro Val  Lys Asn Ile Ala Ser  Thr Ile Ala Gly Ala  Tyr Lys Gln 
    1115                 1120                 1125             


Lys Ile  Glu Thr Ile Ile Gly  Lys Ile Gly 
    1130                 1135             


<210>  1349
<211>  1171
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1349

Met Asn Leu Leu Glu Lys Thr Asn Ala Ala Glu Ser Cys Phe Asn His 
1               5                   10                  15      


Thr Ile Asn Asp Gln Lys Tyr Tyr Phe Ala Gly Tyr Leu Asn Leu Ala 
            20                  25                  30          


Gln Asn Asn Ile Lys Thr Leu Glu Lys Ala Tyr Gly Glu His Phe Leu 
        35                  40                  45              


Cys Ser Gly Asn Asn Pro Ile Ile Asn Asp Leu Thr Asn Thr Asn Ser 
    50                  55                  60                  


Leu Ile Asp Trp Asp Phe Lys Met Lys Phe Leu Ser Gln Tyr Leu Pro 
65                  70                  75                  80  


Ala Ile Ser Tyr Leu Asn Leu Glu Thr Asp Leu Asn Glu Ser Phe Glu 
                85                  90                  95      


Lys Arg Lys Lys Glu Phe Thr Lys Asn Leu Ser Phe Leu Phe Asn Ala 
            100                 105                 110         


Ile Asp Leu Leu Arg Asn Phe Tyr Ser His Tyr Tyr His Ala Pro Leu 
        115                 120                 125             


Ile Asp Glu Leu Asn Ser Glu Arg Leu Ile Phe Leu Asp Lys Ile Phe 
    130                 135                 140                 


Val Ala Val Cys Ile Asn Val Lys Lys Lys Arg Met Lys Asp Asp Lys 
145                 150                 155                 160 


Thr Lys Gln Leu Leu Lys Ala Thr Leu Ile Asp Glu Leu Asp Leu Leu 
                165                 170                 175     


Leu Lys Ala Lys Lys Glu Glu Leu Leu Lys Lys Lys Lys Glu Gly Lys 
            180                 185                 190         


Lys Val Ser Thr Asp Ala Ile Ser Met Lys Asn Ser Val Leu Asn Asp 
        195                 200                 205             


Ala Phe Asn His Leu Ile Gln Leu Glu Lys Asn Ser Lys Lys Glu Ile 
    210                 215                 220                 


Pro Gly Arg Tyr Tyr Thr Ser Leu Leu Asn Asp Asn Asn Lys Tyr Thr 
225                 230                 235                 240 


Glu Asn Gly Ile Asn Ile Ser Ile Ser Gly Leu Leu Phe Leu Leu Ser 
                245                 250                 255     


Met Phe Leu Thr Lys Lys Gln Asn Glu Asp Val Arg Ser Arg Ile Phe 
            260                 265                 270         


Gly Phe Lys Gly Thr Ile Glu Ser Asp Lys Gly Ile Ser Lys Ser Asn 
        275                 280                 285             


Asn Ser Phe Arg Asn Met Ala Thr Asn Trp Val Phe Ser Tyr Leu Ser 
    290                 295                 300                 


Phe Lys Gly Met Lys Lys Gln Leu Gly Ser Thr Phe Asn Lys Glu Ser 
305                 310                 315                 320 


Leu Leu Val Gln Ile Val Asp Glu Leu Ser Lys Val Pro His Glu Val 
                325                 330                 335     


Tyr Gln Thr Leu Ser Pro Ser Arg Gln Glu Met Phe Leu Glu Asp Met 
            340                 345                 350         


Asn Glu Tyr Leu Lys Asp Gly Asn Lys Lys His Cys Leu Glu Asp Ser 
        355                 360                 365             


Ile Val Val His Pro Val Ile Lys Lys Arg Tyr Glu Asp Lys Phe Asn 
    370                 375                 380                 


Tyr Phe Ala Ile Arg Tyr Leu Asp Glu Phe Val Asp Phe Pro Ser Leu 
385                 390                 395                 400 


Arg Phe Gln Val Asn Val Gly Asn Tyr Val His Asp Arg Arg Lys Lys 
                405                 410                 415     


Thr Ile Asp Gly Thr Asn Thr Glu Thr Asp Arg Met Val Lys Glu Glu 
            420                 425                 430         


Ile Arg Ala Phe Gly Lys Leu Ser Phe Ile Ser Lys Leu Lys Ala Asp 
        435                 440                 445             


Tyr Phe Ala Lys Asp Leu Pro Ser Asp Ile Ser Trp Glu Met Tyr Pro 
    450                 455                 460                 


Asn Pro Ser Tyr Asn Phe Ser Ala Asn Asn Ile Pro Val Tyr Ile Asp 
465                 470                 475                 480 


Leu Phe Lys Ser Ser Val Ala Gly Ala Ala Asp Val Gly Lys Asp His 
                485                 490                 495     


Lys Gly Tyr Gln Ala Lys Leu Asp Leu Asp Glu Asp Gly Lys Lys Arg 
            500                 505                 510         


Asn Arg Asn Glu Gly Lys Pro Asp Lys Lys Glu Ile Ala Glu Ile Leu 
        515                 520                 525             


Phe Gly Lys Lys Asn Lys Gln Ile Leu Phe Glu Lys Pro Thr Val Leu 
    530                 535                 540                 


Leu Ser Leu Asn Glu Leu Pro Ala Met Leu Tyr Glu Val Leu Ile Glu 
545                 550                 555                 560 


Asn Gly Asp Lys Gln Asp Ile Gly Lys Arg Ile Glu Asp Lys Ile Val 
                565                 570                 575     


Glu Lys Ile Ile Ala His Tyr Asn Leu Leu Asp Gln Tyr Asp Gly Thr 
            580                 585                 590         


Thr Glu Leu Pro Gly Ser Val Ile Pro Arg Lys Leu Arg Met Gly Gly 
        595                 600                 605             


Asn Glu Lys Ser Ile Asn Ile Asp Lys Leu Leu Arg Ala Val Lys Arg 
    610                 615                 620                 


Glu Leu Glu Ile Thr Gln Glu Lys Leu Asp Leu Ile Lys Thr Asn Gln 
625                 630                 635                 640 


Lys Lys Phe Lys Ser Lys Glu Lys Asp Glu Lys Gly Asn Ser Arg Gln 
                645                 650                 655     


His Val Phe Tyr Thr Asn Glu Leu Gly Gln Glu Ala Thr Trp Ile Ala 
            660                 665                 670         


Asn Asp Met Lys Arg Phe Met Pro Lys Glu Val Lys Glu Lys Trp Arg 
        675                 680                 685             


Gly Tyr His His Ser Asn Leu Gln Lys Leu Leu Ala Leu Tyr Asp Gln 
    690                 695                 700                 


Thr Arg Asn Glu Ala Val Lys Cys Ile Thr Cys Phe Trp Asn Phe Asp 
705                 710                 715                 720 


Gln Gln Thr Ser Trp Gly Lys Gly Ile Lys Glu Ala Phe Tyr Lys Ser 
                725                 730                 735     


Thr Phe Glu Glu Phe Tyr Lys Ala Tyr Leu Glu His Arg Met Asp Val 
            740                 745                 750         


Tyr Lys Thr Leu Glu Asn Asn Leu Ile Ala Gly Lys Gly Tyr Ser Lys 
        755                 760                 765             


Leu Phe Asn Lys Glu Lys Lys Lys Ala Phe Ile Leu Phe Asp Glu His 
    770                 775                 780                 


Leu Tyr Thr Ile Pro Asp Ile Asn Thr Gln Lys Glu Arg Leu Lys Ser 
785                 790                 795                 800 


Thr Leu Phe Ile Leu Pro Arg Gly Ile Phe Asp Ser Lys Pro Thr Phe 
                805                 810                 815     


Ile Lys Gly Ile Lys Tyr Glu Glu Asp Pro Ser Cys Phe Ala Asp Trp 
            820                 825                 830         


Tyr Gln Phe Ala Asn Ala Thr Gly Asn Gln Tyr Gln Arg Phe Tyr Asp 
        835                 840                 845             


Leu Pro Arg Ser Tyr Thr Ser Leu Phe Glu Glu Thr Lys Lys Asn Asn 
    850                 855                 860                 


Glu Gly Leu Ile Glu Asn Lys Lys Gly Leu Ser Ala Lys Glu Gln Leu 
865                 870                 875                 880 


Asp Phe Phe Lys Met Arg Gln Asp Leu Lys Ile Lys Lys Ile Lys Thr 
                885                 890                 895     


Gln Asp Leu Phe Leu Phe Met Ile Val Arg Asp Leu Tyr Lys Lys Val 
            900                 905                 910         


Phe Asp His Thr Leu Pro Leu Glu Ile Gly Leu Arg Asp Met Tyr Gln 
        915                 920                 925             


Thr Pro Ala Glu Arg Gln Ala Asn Tyr Asp Leu Ala Val Lys Gln Ser 
    930                 935                 940                 


Gln Arg Thr Glu Gly Asp Asn Ser Asp Asn Leu Tyr Asn Tyr Asn Phe 
945                 950                 955                 960 


Leu Trp Asn Leu Thr Ile Pro Phe Glu Tyr Asp Lys Ile Lys Glu Pro 
                965                 970                 975     


Gln Val Lys Leu Lys Asp Val Gly Lys Phe Tyr Lys Phe Ala Ala Asp 
            980                 985                 990         


Glu Lys Val Gln Thr Ile Leu Ser  Tyr Ser Asp Arg Glu  Trp Ser Lys 
        995                 1000                 1005             


Leu Asp  Leu Glu Lys Glu Leu  Glu Leu Met Pro Thr  Ser Tyr Glu 
    1010                 1015                 1020             


Val Ile  Arg Arg Glu Gln Leu  Leu Arg Asp Ile Gln  Gln Phe Glu 
    1025                 1030                 1035             


Lys Arg  Ile Leu Glu Asn Tyr  Pro Ser Asp Gly Asn  Ala His Pro 
    1040                 1045                 1050             


Ala Asp  Leu Glu Lys Glu Asp  Lys Asp Lys Lys Cys  Phe Pro Asn 
    1055                 1060                 1065             


Phe Asn  Leu Tyr Leu Leu Lys  Gly Ile Ile Ile Lys  Asn Asn Leu 
    1070                 1075                 1080             


Ala Ser  Glu Glu Glu Arg Gln  Trp Phe Glu Gln Val  His Leu Asp 
    1085                 1090                 1095             


Lys Thr  Pro Phe Tyr Pro Glu  Val Glu Thr Lys Ser  Ser Ile Ile 
    1100                 1105                 1110             


Gln Ser  Ala Tyr Leu Leu Leu  Leu Ile Arg Asn Lys  Met Leu His 
    1115                 1120                 1125             


Asn Gln  Leu Pro Ser Lys Gln  Asn Phe Glu Phe Met  Thr Thr Leu 
    1130                 1135                 1140             


Tyr Pro  Phe Glu Gly Tyr Glu  Ser Tyr Ser Thr Tyr  Leu Leu Phe 
    1145                 1150                 1155             


Val Thr  Lys Lys Thr Ile Glu  Cys Leu Ser Ser Ala  Met 
    1160                 1165                 1170     


<210>  1350
<211>  1062
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1350

Met Asn Phe Glu Glu Asn Gly Asn Lys Tyr Leu Phe Gly Ala Phe Leu 
1               5                   10                  15      


Asn Thr Ala Tyr Asp Asn Tyr Asn Glu Val Ile Ser His Ile Tyr Asp 
            20                  25                  30          


Val Ile Arg Arg Ile Thr Asn Asn Asn Pro Thr Glu Gln Lys Ser Ser 
        35                  40                  45              


Ser Gln Ala Leu Ala Ser Glu Glu Pro Ile Ser Ser Glu Glu Lys Glu 
    50                  55                  60                  


Lys Met Phe Phe Val Cys Thr Ile Leu Ile Ala Gly Asn Ala Thr Ser 
65                  70                  75                  80  


Arg Lys Ile Glu Ser Ile Leu Lys Arg Ala Phe Pro Phe Trp Asp Asp 
                85                  90                  95      


Phe Ile Glu Ile His Ala Ser Leu Ser Ala Gln Leu Asp Lys Thr Glu 
            100                 105                 110         


Ser Ile Phe Gln Leu Gln Lys Asn Cys Val Glu Glu Leu Phe Thr Ala 
        115                 120                 125             


Leu Glu Ser Trp Arg Asn Tyr Thr Thr His Tyr Ile His Pro Glu Ala 
    130                 135                 140                 


Ile Ala Ser Pro Thr Ile Asn Leu Leu Leu Lys Ser Cys Phe Asn Gln 
145                 150                 155                 160 


Gly Ile Lys Glu Ile Lys Lys Arg Phe Asn Thr Lys Asp Glu Gln Leu 
                165                 170                 175     


Thr His Leu Tyr Glu Pro Glu Leu Phe His Asn Lys Glu Thr Asn Lys 
            180                 185                 190         


Asp Glu Ile Lys Cys Tyr His Pro Ala Asn Tyr Tyr Arg Phe Ala Asn 
        195                 200                 205             


Glu Asn Gly Leu Leu Thr Glu Lys Gly Leu Ala Phe Phe Thr Cys Leu 
    210                 215                 220                 


Phe Leu Tyr Lys Arg Glu Ser Tyr Leu Leu Leu Asn Gln Leu Lys Gly 
225                 230                 235                 240 


Phe Lys Arg Ala Asp Glu Glu Arg Tyr Arg Met Thr Leu Glu Ala Phe 
                245                 250                 255     


Thr Val Met Arg Phe Arg Ala Pro Lys Gln Leu Leu Lys Leu Gln Gln 
            260                 265                 270         


Gln Gln Leu Asp Lys Val Ser Leu Gly Ile Ser Met Ile Asn Glu Leu 
        275                 280                 285             


Ala Lys Cys Pro Lys Glu Leu Tyr Asp Cys Leu Glu Asn Glu Lys Arg 
    290                 295                 300                 


Arg Gln Phe Glu Val Tyr Pro Asp Thr Glu Thr Thr Leu Tyr Glu Gln 
305                 310                 315                 320 


Glu Ala Ile Gly Glu Leu Ile Arg Tyr Lys Asp Arg Tyr Glu Asn Leu 
                325                 330                 335     


Met Leu Lys Ala Leu Glu His Ser Ser Glu Cys Lys Tyr Met Gly Phe 
            340                 345                 350         


Tyr Leu Ser Leu Gly Lys Cys Tyr Met Lys Cys Tyr Glu Lys His Tyr 
        355                 360                 365             


Ile Asp Gly Thr Thr Asp Asn Arg Tyr Ile Val His Ser Leu Tyr Gly 
    370                 375                 380                 


Phe Gly Arg Leu Gln Asn Ala Ser Thr Asp His Lys Asn His Leu Ser 
385                 390                 395                 400 


Ser Phe Gly Glu Glu Leu Gln Thr His Ser Gln Leu Pro Val Cys His 
                405                 410                 415     


Phe Ala Thr Glu Asp Asp Ala Ala Asp Ser Pro Thr Ser Val Pro Tyr 
            420                 425                 430         


Ile Ser Glu Ser Tyr Pro Ser Tyr Val Leu Asn Asn Asn Asn Ile Gly 
        435                 440                 445             


Ile Lys Trp Leu Asn Ser Ser Glu Lys Thr Glu Tyr Pro Asn Phe Asn 
    450                 455                 460                 


Leu Asn Glu Gly Lys Val Ser Cys Pro Ala Pro Asp Tyr Trp Leu Ser 
465                 470                 475                 480 


Lys Tyr Glu Leu Pro Ala Met Ala Phe Tyr Ala Tyr Leu Lys Glu Lys 
                485                 490                 495     


His Lys Asn Lys Leu Gln Glu Tyr Pro Ser Ile Lys Glu Leu Ile Asp 
            500                 505                 510         


Gln Ser His Pro Glu Ala Thr Lys Thr Ser Ser Ser Thr Ile Lys Asp 
        515                 520                 525             


Arg Leu Glu Glu Arg Leu Lys Arg Tyr Lys Val Asp Ala Thr Lys Lys 
    530                 535                 540                 


Leu Lys Arg Leu Ala Glu Lys Pro Asp Gly Val Gln Ser Gly Arg Leu 
545                 550                 555                 560 


Ala Asp Glu Leu Ala Arg Asp Ile Leu Trp Leu Gln Pro Ser Ser Pro 
                565                 570                 575     


Lys Glu Gly Gly Lys Asp Lys Leu Thr Gly Ala Asn Phe Gln Ala Leu 
            580                 585                 590         


Gln Tyr Ala Leu Ala Arg Tyr Asp Phe Met Arg Thr Glu Leu Pro Arg 
        595                 600                 605             


Ile Leu Thr Ala Ala Arg Leu Thr Gly Ser Asn Asn Ala His Pro Phe 
    610                 615                 620                 


Leu Asp Lys Ile Asn Pro Gln Asp Tyr Ser Arg Leu Thr Ala Tyr Tyr 
625                 630                 635                 640 


Ala Gly Tyr Leu Thr Gln Lys Ile Val Tyr Ile Asp Lys Gln Leu Glu 
                645                 650                 655     


Lys Leu Ala Arg Gly Lys Val Asn Ile Gln Phe His Pro Thr Arg Lys 
            660                 665                 670         


Leu Ile Arg Gln Ser Gln Thr Asp Ser Val Glu His Glu Lys Glu Thr 
        675                 680                 685             


Val Phe Leu Pro Arg Asn Ile Phe Thr Glu Lys Ile Glu Gln Ala Leu 
    690                 695                 700                 


Cys Gln Ile Gln Gly Asn Phe Lys Leu Asn Ile Glu Lys Ala Arg Ile 
705                 710                 715                 720 


Ser Gly Lys Lys Leu Asn Ala Ser Lys Leu Ile Leu Ile Tyr Leu Glu 
                725                 730                 735     


Leu Tyr Leu Lys Asp Glu Val Pro Glu Phe Tyr Asn Ala Lys Arg Lys 
            740                 745                 750         


Tyr Pro Cys Leu Cys Tyr Pro Leu Thr Pro Ser Glu Lys Tyr Thr Leu 
        755                 760                 765             


Lys Glu Tyr Gln Asp Thr Glu Glu Arg Ser Lys Arg Ile Asp Arg Leu 
    770                 775                 780                 


Lys Cys Phe Tyr Asn Phe Lys Glu Val Ala Glu Lys Val Tyr Leu His 
785                 790                 795                 800 


Lys Glu Leu Ser Glu Asp Glu Asn Lys Arg Tyr Arg Lys Tyr Ile Glu 
                805                 810                 815     


Val Gln Lys Val Ile Asp Asn Glu Lys Ile Ile Arg Leu Arg Lys Val 
            820                 825                 830         


Gln Asp Ile Thr Leu Tyr Leu Trp Thr Arg Leu Phe Ile Glu Glu Asn 
        835                 840                 845             


Pro Glu Gln Ile Phe Phe Ser Lys Asn Glu Lys Pro Glu Asn Ser Leu 
    850                 855                 860                 


Phe Lys Leu Arg Glu Met Asn Asn Ala Ile Leu Asp Asn Thr Thr Ser 
865                 870                 875                 880 


Arg Lys Ile Asn Ile Asn Thr Pro Asn Gly Asn Val Ser Ile Glu Asp 
                885                 890                 895     


Glu Phe Lys Ile Lys Asp Tyr Gly Arg Val Thr Ala Leu Thr Thr Glu 
            900                 905                 910         


Lys Leu Pro Gln Ser Leu Ile Lys Phe Ile Ala Ile Leu Asn Lys Pro 
        915                 920                 925             


Leu Asn Lys Lys Asp Arg Pro Leu Leu Ser Tyr Asp Tyr Ile Tyr His 
    930                 935                 940                 


Glu Thr Asn Ala Phe Tyr Arg Tyr Arg Pro Glu Ile Ile Lys Met Ala 
945                 950                 955                 960 


Gln Asp Ile Glu Asn Lys Ile Ile Asn Asp Leu Lys Ile Asn Val Lys 
                965                 970                 975     


Pro Gln Ala Glu Ser Tyr Tyr Asn Phe Arg Arg Thr Ile Gln Lys Leu 
            980                 985                 990         


Glu Asn Lys Ser Arg Asp Ile Asn  Ile Glu Leu Leu Ile  Lys Ile Arg 
        995                 1000                 1005             


Asn Ala  Phe Cys His Asn Glu  Tyr Lys Glu Leu Asp  Asn Asp Gln 
    1010                 1015                 1020             


Tyr Lys  Tyr Leu Asn Ser Leu  Phe Lys Leu Ser Ser  Asp Ile Lys 
    1025                 1030                 1035             


Gln Thr  Asp Thr Leu Ala Tyr  Leu Leu Tyr Ile Leu  Phe Glu Thr 
    1040                 1045                 1050             


Glu Tyr  Gln Lys Val Met Ile  Leu Lys 
    1055                 1060         


<210>  1351
<211>  1171
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1351

Met Asn Leu Leu Glu Lys Thr Asn Ala Ala Glu Ser Cys Phe Asn His 
1               5                   10                  15      


Thr Ile Asn Asp Gln Lys Tyr Tyr Phe Ala Gly Tyr Leu Asn Leu Ala 
            20                  25                  30          


Gln Asn Asn Ile Lys Thr Leu Glu Lys Ala Tyr Gly Glu His Phe Leu 
        35                  40                  45              


Cys Ser Gly Asn Asn Pro Ile Ile Asn Asp Leu Thr Asn Thr Asn Ser 
    50                  55                  60                  


Leu Ile Asp Trp Asp Phe Lys Met Lys Phe Leu Ser Gln Tyr Leu Pro 
65                  70                  75                  80  


Ala Ile Ser Tyr Leu Asn Leu Glu Thr Asp Leu Asn Glu Ser Phe Glu 
                85                  90                  95      


Lys Arg Lys Lys Glu Phe Thr Lys Asn Leu Ser Phe Leu Phe Asn Ala 
            100                 105                 110         


Ile Asp Leu Leu Arg Asn Phe Tyr Ser His Tyr Tyr His Ala Pro Leu 
        115                 120                 125             


Ile Asp Glu Leu Asn Ser Glu Arg Leu Ile Phe Leu Asp Lys Ile Phe 
    130                 135                 140                 


Val Ala Val Cys Ile Asn Val Lys Lys Lys Arg Met Lys Asp Asp Lys 
145                 150                 155                 160 


Thr Lys Gln Leu Leu Lys Ala Thr Leu Ile Asp Glu Leu Asp Leu Leu 
                165                 170                 175     


Leu Lys Ala Lys Lys Glu Glu Leu Leu Lys Lys Lys Lys Glu Gly Lys 
            180                 185                 190         


Lys Val Ser Thr Asp Ala Ile Ser Met Lys Asn Ser Val Leu Asn Asp 
        195                 200                 205             


Ala Phe Asn His Leu Ile Gln Leu Glu Lys Asn Ser Lys Lys Glu Ile 
    210                 215                 220                 


Pro Gly Arg Tyr Tyr Thr Ser Leu Leu Asn Asp Asn Asn Lys Tyr Thr 
225                 230                 235                 240 


Glu Asn Gly Ile Asn Ile Ser Ile Ser Gly Leu Leu Phe Leu Leu Ser 
                245                 250                 255     


Met Phe Leu Thr Lys Lys Gln Asn Glu Asp Val Arg Ser Arg Ile Phe 
            260                 265                 270         


Gly Phe Lys Gly Thr Ile Glu Ser Asp Lys Gly Ile Ser Lys Ser Asn 
        275                 280                 285             


Asn Ser Phe Arg Asn Met Ala Thr Asn Trp Val Phe Ser Tyr Leu Ser 
    290                 295                 300                 


Phe Lys Gly Met Lys Lys Gln Leu Gly Ser Thr Phe Asn Lys Glu Ser 
305                 310                 315                 320 


Leu Leu Val Gln Ile Val Asp Glu Leu Ser Lys Val Pro His Glu Val 
                325                 330                 335     


Tyr Gln Thr Leu Ser Pro Ser Arg Gln Glu Met Phe Leu Glu Asp Met 
            340                 345                 350         


Asn Glu Tyr Leu Lys Asp Gly Asn Lys Lys His Cys Leu Glu Asp Ser 
        355                 360                 365             


Ile Val Val His Pro Val Ile Lys Lys Arg Tyr Glu Asp Lys Phe Asn 
    370                 375                 380                 


Tyr Phe Ala Ile Arg Tyr Leu Asp Glu Phe Val Asp Phe Pro Ser Leu 
385                 390                 395                 400 


Arg Phe Gln Val Asn Val Gly Asn Tyr Val His Asp Arg Arg Lys Lys 
                405                 410                 415     


Thr Ile Asp Gly Thr Asn Thr Glu Thr Asp Arg Met Val Lys Glu Glu 
            420                 425                 430         


Ile Arg Ala Phe Gly Lys Leu Ser Phe Ile Ser Lys Leu Lys Ala Asp 
        435                 440                 445             


Tyr Phe Ala Lys Asp Leu Pro Ser Asp Ile Ser Trp Glu Met Tyr Pro 
    450                 455                 460                 


Asn Pro Ser Tyr Asn Phe Ser Ala Asn Asn Ile Pro Val Tyr Ile Asp 
465                 470                 475                 480 


Leu Phe Lys Ser Ser Val Ala Gly Ala Ala Asp Val Gly Lys Asp His 
                485                 490                 495     


Lys Gly Tyr Gln Ala Lys Leu Asp Leu Asp Glu Asp Gly Lys Lys Arg 
            500                 505                 510         


Asn Arg Asn Glu Gly Lys Pro Asp Lys Lys Glu Ile Ala Glu Ile Leu 
        515                 520                 525             


Phe Gly Lys Lys Asn Lys Gln Ile Leu Phe Glu Lys Pro Thr Val Leu 
    530                 535                 540                 


Leu Ser Leu Asn Glu Leu Pro Ala Met Leu Tyr Glu Val Leu Ile Glu 
545                 550                 555                 560 


Asn Gly Asp Lys Gln Asp Ile Gly Lys Arg Ile Glu Asp Lys Ile Val 
                565                 570                 575     


Glu Lys Ile Ile Ala His Tyr Asn Leu Leu Asp Gln Tyr Asp Gly Thr 
            580                 585                 590         


Thr Glu Leu Pro Gly Ser Val Ile Pro Arg Lys Leu Arg Met Gly Gly 
        595                 600                 605             


Asn Glu Lys Ser Ile Asn Ile Asp Lys Leu Leu Arg Ala Val Lys Arg 
    610                 615                 620                 


Glu Leu Glu Ile Thr Gln Glu Lys Leu Asp Leu Ile Lys Thr Asn Gln 
625                 630                 635                 640 


Lys Lys Phe Lys Ser Lys Glu Lys Asp Glu Lys Gly Asn Ser Arg Gln 
                645                 650                 655     


His Val Phe Tyr Thr Asn Glu Leu Gly Gln Glu Ala Thr Trp Ile Ala 
            660                 665                 670         


Asn Asp Met Lys Arg Phe Met Pro Lys Glu Val Lys Glu Lys Trp Arg 
        675                 680                 685             


Gly Tyr His His Ser Asn Leu Gln Lys Leu Leu Ala Leu Tyr Asp Gln 
    690                 695                 700                 


Thr Arg Asn Glu Ala Val Lys Cys Ile Thr Cys Phe Trp Asn Phe Asp 
705                 710                 715                 720 


Gln Gln Thr Ser Trp Gly Lys Gly Ile Lys Glu Ala Phe Tyr Lys Ser 
                725                 730                 735     


Thr Phe Glu Glu Phe Tyr Lys Ala Tyr Leu Glu His Arg Met Asp Val 
            740                 745                 750         


Tyr Lys Thr Leu Glu Asn Asn Leu Ile Ala Gly Lys Gly Tyr Ser Lys 
        755                 760                 765             


Leu Phe Asn Lys Glu Lys Lys Lys Ala Phe Ile Leu Phe Asp Glu His 
    770                 775                 780                 


Leu Tyr Thr Ile Pro Asp Ile Asn Thr Gln Lys Glu Arg Leu Lys Ser 
785                 790                 795                 800 


Thr Leu Phe Ile Leu Pro Arg Gly Ile Phe Asp Ser Lys Pro Thr Phe 
                805                 810                 815     


Ile Lys Gly Ile Lys Tyr Glu Glu Asp Pro Ser Cys Phe Ala Asp Trp 
            820                 825                 830         


Tyr Gln Phe Ala Asn Ala Thr Gly Asn Gln Tyr Gln Arg Phe Tyr Asp 
        835                 840                 845             


Leu Pro Arg Ser Tyr Thr Ser Leu Phe Glu Glu Thr Lys Lys Asn Asn 
    850                 855                 860                 


Glu Gly Leu Ile Glu Asn Lys Lys Gly Leu Ser Ala Lys Glu Gln Leu 
865                 870                 875                 880 


Asp Phe Phe Lys Met Arg Gln Asp Leu Lys Ile Lys Lys Ile Lys Thr 
                885                 890                 895     


Gln Asp Leu Phe Leu Phe Met Ile Val Arg Asp Leu Tyr Lys Lys Val 
            900                 905                 910         


Phe Asp His Thr Leu Pro Leu Glu Ile Gly Leu Arg Asp Met Tyr Gln 
        915                 920                 925             


Thr Pro Ala Glu Arg Gln Ala Asn Tyr Asp Leu Ala Val Lys Gln Ser 
    930                 935                 940                 


Gln Arg Thr Glu Gly Asp Asn Ser Asp Asn Leu Tyr Asn Tyr Asn Phe 
945                 950                 955                 960 


Leu Trp Asn Leu Thr Ile Pro Phe Glu Tyr Asp Lys Ile Lys Glu Pro 
                965                 970                 975     


Gln Val Lys Leu Lys Asp Val Gly Lys Phe Tyr Lys Phe Ala Ala Asp 
            980                 985                 990         


Glu Lys Val Gln Thr Ile Leu Ser  Tyr Ser Asp Arg Glu  Trp Ser Lys 
        995                 1000                 1005             


Leu Asp  Leu Glu Lys Glu Leu  Glu Leu Met Pro Thr  Ser Tyr Glu 
    1010                 1015                 1020             


Val Ile  Arg Arg Glu Gln Leu  Leu Arg Asp Ile Gln  Gln Phe Glu 
    1025                 1030                 1035             


Lys Arg  Ile Leu Glu Asn Tyr  Pro Ser Asp Gly Asn  Ala His Pro 
    1040                 1045                 1050             


Ala Asp  Leu Glu Lys Glu Asp  Lys Asp Lys Lys Cys  Phe Pro Asn 
    1055                 1060                 1065             


Phe Asn  Leu Tyr Leu Leu Lys  Gly Ile Ile Ile Lys  Asn Asn Leu 
    1070                 1075                 1080             


Ala Ser  Glu Glu Glu Arg Gln  Trp Phe Glu Gln Val  His Leu Asp 
    1085                 1090                 1095             


Lys Thr  Pro Phe Tyr Pro Glu  Val Glu Thr Lys Ser  Ser Ile Ile 
    1100                 1105                 1110             


Gln Ser  Ala Tyr Leu Leu Leu  Leu Ile Arg Asn Lys  Met Leu His 
    1115                 1120                 1125             


Asn Gln  Leu Pro Ser Lys Gln  Asn Phe Glu Phe Met  Thr Thr Leu 
    1130                 1135                 1140             


Tyr Pro  Phe Glu Gly Tyr Glu  Ser Tyr Ser Thr Tyr  Leu Leu Phe 
    1145                 1150                 1155             


Val Thr  Lys Lys Thr Ile Glu  Cys Leu Ser Ser Ala  Met 
    1160                 1165                 1170     


<210>  1352
<211>  1119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1352

Met Glu Asp Asp Lys Lys Thr Thr Glu Ser Ile Arg Tyr Glu Leu Lys 
1               5                   10                  15      


Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val 
            20                  25                  30          


Tyr Ile Thr Val Asn His Ile Asn Lys Met Leu Glu Glu Gly Glu Ile 
        35                  40                  45              


Asn Arg Asp Gly Tyr Glu Asn Thr Leu Glu Asn Ser Trp Asn Glu Ile 
    50                  55                  60                  


Lys Asp Ile Asn Lys Lys Asp Arg Leu Ser Lys Leu Ile Ile Lys His 
65                  70                  75                  80  


Phe Pro Phe Leu Glu Ala Thr Thr Tyr Arg Arg Asn Pro Thr Asp Thr 
                85                  90                  95      


Thr Lys Gln Lys Glu Glu Lys Gln Ala Glu Ala Gln Ser Leu Glu Ser 
            100                 105                 110         


Leu Lys Glu Ser Phe Phe Val Phe Ile Tyr Lys Leu Arg Asp Leu Arg 
        115                 120                 125             


Asn His Tyr Ser His Tyr Lys His Ser Lys Ser Leu Glu Arg Pro Lys 
    130                 135                 140                 


Phe Glu Glu Asp Leu Leu Lys Lys Met Tyr Asn Ile Phe Asn Ala Ser 
145                 150                 155                 160 


Ile Arg Leu Val Lys Glu Asp Tyr Gln Tyr Asn Lys Asn Ile Asn Pro 
                165                 170                 175     


Lys Lys Asp Phe Lys His Leu Asp Arg Lys Arg Lys Gly Lys Phe Tyr 
            180                 185                 190         


Tyr Ser Phe Ala Asp Asn Lys Gly Asn Ile Thr Glu Ser Gly Leu Leu 
        195                 200                 205             


Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Val Gln 
    210                 215                 220                 


Lys Lys Leu Glu Gly Phe Lys Cys Ser Asn Glu Ser Tyr Gln Lys Met 
225                 230                 235                 240 


Thr Asn Glu Val Phe Cys Arg Ser Arg Met Leu Leu Pro Lys Leu Arg 
                245                 250                 255     


Leu Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu Asn 
            260                 265                 270         


Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Gln Gly Asn 
        275                 280                 285             


Asp Arg Glu Lys Phe Arg Val Pro Phe Asp Pro Val Asp Glu Asp Tyr 
    290                 295                 300                 


Asp Ala Glu Gln Glu Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp 
305                 310                 315                 320 


Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Tyr Asn Glu Ile Phe 
                325                 330                 335     


Thr Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile 
            340                 345                 350         


Tyr Lys Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg His Leu Thr His 
        355                 360                 365             


Lys Leu Tyr Gly Phe Glu Arg Ile Gln Glu Phe Asp Lys Gln Asn Arg 
    370                 375                 380                 


Pro Asp Glu Trp Lys Ala Ile Val Lys Asp Ser Asp Thr Phe Lys Lys 
385                 390                 395                 400 


Lys Glu Glu Lys Glu Glu Glu Lys Pro Tyr Ile Ser Glu Thr Thr Pro 
                405                 410                 415     


His Tyr His Leu Glu Asn Lys Lys Ile Gly Ile Ala Phe Lys Asn His 
            420                 425                 430         


Asn Ile Trp Pro Ser Thr Gln Thr Glu Leu Thr Asn Asn Lys Arg Lys 
        435                 440                 445             


Lys Tyr Asn Leu Gly Thr Ser Ile Lys Ala Glu Ala Phe Leu Ser Val 
    450                 455                 460                 


His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Lys Thr Glu 
465                 470                 475                 480 


Asn Thr Lys Asn Asp Asn Lys Val Glu Gly Lys Lys Glu Thr Lys Lys 
                485                 490                 495     


Gln Glu Lys His Asn Ile Glu Ala Ile Ile Glu Ser Lys Ile Lys Asp 
            500                 505                 510         


Met Tyr Ala Leu Tyr Asp Ala Phe Ala Asn Gly Glu Ile Asn Ser Glu 
        515                 520                 525             


Lys Glu Leu Glu Glu Tyr Leu Lys Gly Lys Asp Ile Glu Ile Val His 
    530                 535                 540                 


Leu Pro Lys Gln Met Ile Ala Ile Leu Lys Asn Lys His Lys Asp Met 
545                 550                 555                 560 


Val Glu Lys Ala Glu Asp Lys Gln Glu Lys Met Lys Leu Ala Thr Glu 
                565                 570                 575     


Asn Arg Leu Lys Thr Leu Asp Lys Gln Leu Lys Gly Lys Ile Gln Asn 
            580                 585                 590         


Gly Lys Lys Tyr Asn Ser Ala Pro Lys Ser Gly Glu Ile Ala Ser Trp 
        595                 600                 605             


Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln Arg Asp Glu Asn 
    610                 615                 620                 


Gly Glu Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln Leu 
625                 630                 635                 640 


Leu Gln Arg Thr Leu Ala Phe Phe Gly Ser Glu His Glu Arg Leu Ala 
                645                 650                 655     


Pro Tyr Phe Lys Gln Thr Asn Leu Ile Glu Ser Ser Asn Pro His Pro 
            660                 665                 670         


Phe Leu Asn Asp Thr Glu Trp Glu Lys Cys Ser Asn Ile Leu Ser Phe 
        675                 680                 685             


Tyr Arg Ser Tyr Leu Lys Ala Lys Lys Asn Phe Leu Glu Ser Leu Lys 
    690                 695                 700                 


Pro Glu Asp Trp Glu Lys Asn Gln Tyr Phe Leu Met Leu Lys Glu Pro 
705                 710                 715                 720 


Lys Thr Asn Arg Lys Thr Leu Val Gln Gly Trp Lys Asn Gly Phe Asn 
                725                 730                 735     


Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg Lys Trp Phe Met Glu 
            740                 745                 750         


His Trp Lys Asn Ile Lys Val Asp Asp Ser Lys Arg Val Gly Leu Val 
        755                 760                 765             


Ala Lys Val Ile Pro Leu Phe Phe Ser Glu Lys Tyr Lys Asp Ser Val 
    770                 775                 780                 


Gln Pro Phe Tyr Asn Tyr Pro Phe Asn Val Gly Asp Val Asn Lys Pro 
785                 790                 795                 800 


Lys Glu Glu Asp Phe Leu His Arg Lys Asp Arg Ile Glu Leu Trp Asp 
                805                 810                 815     


Lys Lys Lys Val Gly Phe Lys Gly Tyr Lys Ala Lys Glu Lys Pro Lys 
            820                 825                 830         


Glu Met Thr Asp Glu Glu Lys Lys Glu His Arg Ser Tyr Leu Glu Phe 
        835                 840                 845             


Gln Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Val Arg Asn Gln 
    850                 855                 860                 


Asp Ile Val Thr Trp Leu Leu Cys Thr Glu Leu Ile Asp Lys Leu Lys 
865                 870                 875                 880 


Val Glu Gly Leu Asn Val Glu Glu Leu Gln Lys Leu Arg Leu Lys Asp 
                885                 890                 895     


Ile Asn Thr Asp Thr Ala Lys Lys Glu Lys Asn Asn Ile Leu Asn Arg 
            900                 905                 910         


Val Met Pro Met Glu Leu Pro Val Thr Val Tyr Glu Val Asn Lys Ala 
        915                 920                 925             


Ser Asn Ile Ile Lys Asn Lys Pro Leu His Thr Ile Tyr Ile Lys Glu 
    930                 935                 940                 


Ala Lys Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys 
945                 950                 955                 960 


Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Val Asp Thr Ser Ser Lys 
                965                 970                 975     


Ala Glu Ser Glu Ser Asn Thr Ile Ser Lys Ser Arg Val Glu Tyr Glu 
            980                 985                 990         


Leu Val Glu Tyr Gln Lys Ala Arg  Ile Glu Ile Ile Lys  Asp Met Leu 
        995                 1000                 1005             


Ala Leu  Glu Lys Thr Leu Ile  Asp Lys Tyr Asn Ser  Leu Asp Thr 
    1010                 1015                 1020             


Asp Asn  Phe Asn Lys Met Leu  Thr Asp Trp Leu Glu  Leu Lys Gly 
    1025                 1030                 1035             


Glu Pro  Asp Lys Ala Ser Phe  Gln Asn Asp Val Asp  Leu Leu Ile 
    1040                 1045                 1050             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Arg Asn 
    1055                 1060                 1065             


Arg Ile  Ala Phe Ala Asn Ile  Asn Pro Phe Ser Leu  Ser Ser Ala 
    1070                 1075                 1080             


Asp Thr  Ser Glu Glu Lys Gly  Leu Gly Ile Ala Asn  Gln Leu Lys 
    1085                 1090                 1095             


Asp Lys  Thr His Lys Thr Ile  Glu Lys Ile Ile Glu  Ile Glu Lys 
    1100                 1105                 1110             


Pro Ile  Glu Thr Lys Glu 
    1115                 


<210>  1353
<211>  1150
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1353

Met Met Glu Lys Glu Asn Val Gln Gly Ser His Ile Tyr Tyr Glu His 
1               5                   10                  15      


Thr Asp Lys Cys Phe Trp Ala Ala Phe Tyr Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Leu Thr Ile Ala His Ile Asn Ser Phe Val Asn Ser Lys Lys 
        35                  40                  45              


Gly Ile Asn Asn Asp Asp Lys Val Leu Asp Ile Ile Asp Asp Trp Ser 
    50                  55                  60                  


Lys Phe Asp Asn Asp Leu Leu Met Gly Ala Arg Leu Asn Lys Leu Ile 
65                  70                  75                  80  


Phe Lys His Phe Pro Phe Leu Lys Ala Pro Leu Tyr Glu Leu Ala Lys 
                85                  90                  95      


Gln Glu Ala Leu Lys Gln Tyr Lys Lys Glu Gln Gln Lys Tyr Gly Lys 
            100                 105                 110         


Lys Gly Lys Lys Lys Glu Val Phe Ile Gln Glu Ala Met Ala Asn Ala 
        115                 120                 125             


Phe Lys Met Glu Asp Val Arg Lys Thr Leu Arg Glu Phe Leu Lys Gln 
    130                 135                 140                 


Leu Glu Asp Leu Arg Asn His Phe Ser His Tyr Asn Tyr Asn Ser Pro 
145                 150                 155                 160 


Ala Glu Lys Thr Glu Val Lys Phe Asp Asn Gly Phe Cys Asn Lys Leu 
                165                 170                 175     


Tyr Tyr Val Phe Asp Ala Ala Leu Gln Met Val Lys Asp Asp Asn Arg 
            180                 185                 190         


Met Asn Pro Glu Ile Asn Met Gln Thr Asp Phe Glu His Leu Val Arg 
        195                 200                 205             


Leu Gly Arg Asn Arg Lys Ile Pro Asn Thr Phe Lys Tyr Asn Phe Thr 
    210                 215                 220                 


Asn Ser Asp Gly Thr Ile Asn Asn Asn Gly Leu Leu Phe Phe Val Ser 
225                 230                 235                 240 


Leu Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Lys 
                245                 250                 255     


Gly Phe Lys Gly Gly Thr Glu Asn Tyr Met Arg Met Thr Asn Glu Val 
            260                 265                 270         


Phe Cys Arg Asn Arg Met Val Ile Pro Lys Leu Arg Leu Glu Thr Asp 
        275                 280                 285             


Tyr Asp Asn His Gln Leu Met Phe Asp Met Leu Asn Glu Leu Val Arg 
    290                 295                 300                 


Cys Pro Leu Ser Leu Tyr Lys Arg Leu Lys Lys Glu Asp Gln Asp Lys 
305                 310                 315                 320 


Phe Arg Val Pro Ile Glu Phe Leu Asp Glu Ala Asn Glu Ala Asp Asn 
                325                 330                 335     


Pro Tyr Gln Glu Asn Ala Asn Ser Asp Glu Asn Pro Thr Glu Glu Thr 
            340                 345                 350         


Asp Pro Leu Lys Asn Thr Leu Val Arg His Gln His Arg Phe Pro Tyr 
        355                 360                 365             


Phe Val Leu Arg Tyr Phe Asp Leu Asn Glu Val Phe Lys Gln Leu Arg 
    370                 375                 380                 


Phe Gln Ile Asn Leu Gly Cys Tyr His Phe Ser Ile Tyr Asp Lys Thr 
385                 390                 395                 400 


Ile Gly Glu Arg Thr Glu Lys Arg His Leu Thr Arg Thr Leu Phe Gly 
                405                 410                 415     


Phe Asp Arg Leu Gln Asn Phe Ser Val Lys Leu Gln Pro Gln His Trp 
            420                 425                 430         


Lys Asn Met Val Lys His Leu Asp Thr Glu Glu Ser Ser Asp Lys Pro 
        435                 440                 445             


Tyr Leu Ser Asp Ala Met Pro His Tyr Gln Ile Glu Asn Glu Lys Ile 
    450                 455                 460                 


Gly Ile His Phe Leu Lys Thr Asp Thr Glu Lys Lys Glu Thr Val Trp 
465                 470                 475                 480 


Pro Ser Leu Glu Val Glu Glu Val Ser Ser Asn Arg Asn Lys Tyr Lys 
                485                 490                 495     


Ser Glu Lys Asn Leu Thr Ala Asp Ala Phe Leu Ser Thr His Glu Leu 
            500                 505                 510         


Leu Pro Met Met Phe Tyr Tyr Gln Leu Leu Ser Ser Glu Glu Lys Thr 
        515                 520                 525             


Arg Ala Ala Ala Gly Asp Lys Val Gln Gly Val Leu Gln Ser Tyr Arg 
    530                 535                 540                 


Lys Lys Ile Phe Asp Ile Tyr Asp Asp Phe Ala Asn Gly Thr Ile Asn 
545                 550                 555                 560 


Ser Met Gln Lys Leu Asp Glu Arg Leu Ala Lys Asp Asn Leu Leu Ser 
                565                 570                 575     


Gly Asn Met Pro Gln Gln Met Leu Ala Ile Leu Glu His Gln Glu Pro 
            580                 585                 590         


Asp Met Glu Gln Lys Ala Lys Glu Lys Arg Asp Arg Leu Ile Thr Glu 
        595                 600                 605             


Thr Glu Glu Arg Ile Asp Lys Leu Asn Ala Gln Phe Lys Gln Lys Val 
    610                 615                 620                 


Arg Ile Gly Lys Arg Arg Ala Asp Leu Pro Lys Val Gly Cys Ile Ala 
625                 630                 635                 640 


Asp Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Ala Lys Arg Ser 
                645                 650                 655     


Ala Asp Asn Thr Gly Val Pro Gly Ser Lys Ala Asn Ser Thr Glu Tyr 
            660                 665                 670         


Arg Leu Leu Gln Glu Ala Leu Ala Phe Tyr Ser Thr Tyr Lys Asp Arg 
        675                 680                 685             


Leu Glu Pro Tyr Phe Arg Gln Val Asn Leu Ile Gly Gly Thr Asn Pro 
    690                 695                 700                 


His Pro Phe Leu His Asn Val Lys Trp Gln Lys Cys Asn His Leu Leu 
705                 710                 715                 720 


Ser Phe Tyr Tyr Ala Tyr Leu Asn Ala Lys Lys Arg Tyr Leu Ser His 
                725                 730                 735     


Leu Ser Pro Ala Asp Trp Gln Lys His Gln His Phe Leu Leu Leu Lys 
            740                 745                 750         


Val Arg Lys Asp Ile Gln Asn Glu Lys Lys Asp Trp Lys Lys Ser Leu 
        755                 760                 765             


Val Ala Gly Trp Lys Asn Gly Phe Asn Leu Pro Arg Gly Leu Phe Thr 
    770                 775                 780                 


Glu Ser Ile Lys Thr Trp Phe Ser Thr Tyr Ala Asp Lys Val Gln Ile 
785                 790                 795                 800 


Thr Asp Thr Lys Leu Phe Glu Asn Arg Val Gly Leu Ile Ala Lys Leu 
                805                 810                 815     


Ile Pro Leu Tyr Tyr Asp Lys Val Tyr Asn Asp Lys Pro Gln Pro Phe 
            820                 825                 830         


Tyr Gln Tyr Pro Phe Asn Ile Asn Asp Arg Tyr Lys Pro Glu Asp Ala 
        835                 840                 845             


Arg Lys Gln Phe Thr Ala Ala Ser Ser Lys Leu Trp Asn Glu Lys Lys 
    850                 855                 860                 


Thr Arg Tyr Lys Asn Ala Gln Pro Glu Gln Leu Lys Lys Lys Lys Asp 
865                 870                 875                 880 


Leu Gln Tyr Leu Asp Phe Leu Ser Trp Lys Lys Leu Glu Arg Glu Leu 
                885                 890                 895     


Arg Met Leu Arg Asn Gln Asp Met Met Val Trp Leu Met Cys Lys Asp 
            900                 905                 910         


Leu Phe Ala Gln Cys Thr Val Glu Gly Val Glu Phe Ala Asp Leu Lys 
        915                 920                 925             


Leu Ser Gln Leu Glu Val Asp Val Thr Val Gln Asp Asn Leu Asn Val 
    930                 935                 940                 


Leu Asn Asn Val Ser Ser Met Ile Leu Pro Leu Ser Val Tyr Pro Leu 
945                 950                 955                 960 


Asp Ala Gln Gly Asn Ile Arg Arg Asn Ser Lys Pro Leu Tyr Thr Val 
                965                 970                 975     


Tyr Val Gln Glu Lys Asn Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys 
            980                 985                 990         


Ser Leu Leu Lys Asp Arg Arg Leu  Asn Gly Leu Phe Ser  Phe Ile Pro 
        995                 1000                 1005             


Ala Glu  Gly Glu Asp Leu Gln  Gln His Pro Leu Thr  Lys Asn Arg 
    1010                 1015                 1020             


Leu Glu  Tyr Glu Leu Ser Ile  Tyr Gln Thr Met Arg  Ile Ser Val 
    1025                 1030                 1035             


Phe Glu  Gln Thr Leu Gln Leu  Glu Lys Ala Ile Leu  Thr Arg Asn 
    1040                 1045                 1050             


Lys Thr  Leu Cys Gly Asn Asn  Phe Asn Asn Leu Leu  Asn Ser Trp 
    1055                 1060                 1065             


Ser Glu  His Arg Thr Asp Lys  Lys Thr Leu Gln Pro  Asp Ile Asp 
    1070                 1075                 1080             


Phe Leu  Ile Ala Val Arg Asn  Ala Phe Ser His Asn  Gln Tyr Pro 
    1085                 1090                 1095             


Met Ser  Thr Asn Thr Val Met  Glu Asp Ile Glu Lys  Phe Asn Ile 
    1100                 1105                 1110             


Arg Thr  Ser Arg Leu Ala Asp  Lys Asp Gly Leu Gly  Ile Ala Ser 
    1115                 1120                 1125             


Gln Leu  Ala Lys Lys Thr Lys  Asp Ala Ala Ser Arg  Leu Gln Asn 
    1130                 1135                 1140             


Ile Ile  Asn Gly Gly Thr Asn  
    1145                 1150 


<210>  1354
<211>  1062
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1354

Met Asn Phe Glu Glu Asn Gly Asn Lys Tyr Leu Phe Gly Ala Phe Leu 
1               5                   10                  15      


Asn Thr Ala Tyr Asp Asn Tyr Asn Glu Val Ile Ser His Ile Tyr Asp 
            20                  25                  30          


Val Ile Arg Arg Ile Thr Asn Asn Asn Pro Thr Glu Gln Lys Ser Ser 
        35                  40                  45              


Ser Gln Ala Leu Ala Ser Glu Glu Pro Ile Ser Ser Glu Glu Lys Glu 
    50                  55                  60                  


Lys Met Phe Phe Val Cys Thr Ile Leu Ile Ala Gly Asn Ala Thr Ser 
65                  70                  75                  80  


Arg Lys Ile Glu Ser Ile Leu Lys Arg Ala Phe Pro Phe Trp Asp Asp 
                85                  90                  95      


Phe Ile Glu Ile His Ala Ser Leu Ser Ala Gln Leu Asp Lys Thr Glu 
            100                 105                 110         


Ser Ile Phe Gln Leu Gln Lys Asn Cys Val Glu Glu Leu Phe Thr Ala 
        115                 120                 125             


Leu Glu Ser Trp Arg Asn Tyr Thr Thr His Tyr Ile His Pro Glu Ala 
    130                 135                 140                 


Ile Ala Ser Pro Thr Ile Asn Leu Leu Leu Lys Ser Cys Phe Asn Gln 
145                 150                 155                 160 


Gly Ile Lys Glu Ile Lys Lys Arg Phe Asn Thr Lys Asp Glu Gln Leu 
                165                 170                 175     


Thr His Leu Tyr Glu Pro Glu Leu Phe His Asn Lys Glu Thr Asn Lys 
            180                 185                 190         


Asp Glu Ile Lys Cys Tyr His Pro Ala Asn Tyr Tyr Arg Phe Ala Asn 
        195                 200                 205             


Glu Asn Gly Leu Leu Thr Glu Lys Gly Leu Ala Phe Phe Thr Cys Leu 
    210                 215                 220                 


Phe Leu Tyr Lys Arg Glu Ser Tyr Leu Leu Leu Asn Gln Leu Lys Gly 
225                 230                 235                 240 


Phe Lys Arg Ala Asp Glu Glu Arg Tyr Arg Met Thr Leu Glu Ala Phe 
                245                 250                 255     


Thr Val Met Arg Phe Arg Ala Pro Lys Gln Leu Leu Lys Leu Gln Gln 
            260                 265                 270         


Gln Gln Leu Asp Lys Val Ser Leu Gly Ile Ser Met Ile Asn Glu Leu 
        275                 280                 285             


Ala Lys Cys Pro Lys Glu Leu Tyr Asp Cys Leu Glu Asn Glu Lys Arg 
    290                 295                 300                 


Arg Gln Phe Glu Val Tyr Pro Asp Thr Glu Thr Thr Leu Tyr Glu Gln 
305                 310                 315                 320 


Glu Ala Ile Gly Glu Leu Ile Arg Tyr Lys Asp Arg Tyr Glu Asn Leu 
                325                 330                 335     


Met Leu Lys Ala Leu Glu His Ser Ser Glu Cys Lys Tyr Met Gly Phe 
            340                 345                 350         


Tyr Leu Ser Leu Gly Lys Cys Tyr Met Lys Cys Tyr Glu Lys His Tyr 
        355                 360                 365             


Ile Asp Gly Thr Thr Asp Asn Arg Tyr Ile Val His Ser Leu Tyr Gly 
    370                 375                 380                 


Phe Gly Arg Leu Gln Asn Ala Ser Thr Asp His Lys Asn His Leu Ser 
385                 390                 395                 400 


Ser Phe Gly Glu Glu Leu Gln Thr His Ser Gln Leu Pro Val Cys His 
                405                 410                 415     


Phe Ala Thr Glu Asp Asp Ala Ala Asp Ser Pro Thr Ser Val Pro Tyr 
            420                 425                 430         


Ile Ser Glu Ser Tyr Pro Ser Tyr Val Leu Asn Asn Asn Asn Ile Gly 
        435                 440                 445             


Ile Lys Trp Leu Asn Ser Ser Glu Lys Thr Glu Tyr Pro Asn Phe Asn 
    450                 455                 460                 


Leu Asn Glu Gly Lys Val Ser Cys Pro Ala Pro Asp Tyr Trp Leu Ser 
465                 470                 475                 480 


Lys Tyr Glu Leu Pro Ala Met Ala Phe Tyr Ala Tyr Leu Lys Glu Lys 
                485                 490                 495     


His Lys Asn Lys Leu Gln Glu Tyr Pro Ser Ile Lys Glu Leu Ile Asp 
            500                 505                 510         


Gln Ser His Pro Glu Ala Thr Lys Thr Ser Ser Ser Thr Ile Lys Asp 
        515                 520                 525             


Arg Leu Glu Glu Arg Leu Lys Arg Tyr Lys Val Asp Ala Thr Lys Lys 
    530                 535                 540                 


Leu Lys Arg Leu Ala Glu Lys Pro Asp Gly Val Gln Ser Gly Arg Leu 
545                 550                 555                 560 


Ala Asp Glu Leu Ala Arg Asp Ile Leu Trp Leu Gln Pro Ser Ser Pro 
                565                 570                 575     


Lys Glu Gly Gly Lys Asp Lys Leu Thr Gly Ala Asn Phe Gln Ala Leu 
            580                 585                 590         


Gln Tyr Ala Leu Ala Arg Tyr Asp Phe Met Arg Thr Glu Leu Pro Arg 
        595                 600                 605             


Ile Leu Thr Ala Ala Arg Leu Thr Gly Ser Asn Asn Ala His Pro Phe 
    610                 615                 620                 


Leu Asp Lys Ile Asn Pro Gln Asp Tyr Ser Arg Leu Thr Ala Tyr Tyr 
625                 630                 635                 640 


Ala Gly Tyr Leu Thr Gln Lys Ile Val Tyr Ile Asp Lys Gln Leu Glu 
                645                 650                 655     


Lys Leu Ala Arg Gly Lys Val Asn Ile Gln Phe His Pro Thr Arg Lys 
            660                 665                 670         


Leu Ile Arg Gln Ser Gln Thr Asp Ser Val Glu His Glu Lys Glu Thr 
        675                 680                 685             


Val Phe Leu Pro Arg Asn Ile Phe Thr Glu Lys Ile Glu Gln Ala Leu 
    690                 695                 700                 


Cys Gln Ile Gln Gly Asn Phe Lys Leu Asn Ile Glu Lys Ala Arg Ile 
705                 710                 715                 720 


Ser Gly Lys Lys Leu Asn Ala Ser Lys Leu Ile Leu Ile Tyr Leu Glu 
                725                 730                 735     


Leu Tyr Leu Lys Asp Glu Val Pro Glu Phe Tyr Asn Ala Lys Arg Lys 
            740                 745                 750         


Tyr Pro Cys Leu Cys Tyr Pro Leu Thr Pro Ser Glu Lys Tyr Thr Leu 
        755                 760                 765             


Lys Glu Tyr Gln Asp Thr Glu Glu Arg Ser Lys Arg Ile Asp Arg Leu 
    770                 775                 780                 


Lys Cys Phe Tyr Asn Phe Lys Glu Val Ala Glu Lys Val Tyr Leu His 
785                 790                 795                 800 


Lys Glu Leu Ser Glu Asp Glu Asn Lys Arg Tyr Arg Lys Tyr Ile Glu 
                805                 810                 815     


Val Gln Lys Val Ile Asp Asn Glu Lys Ile Ile Arg Leu Arg Lys Val 
            820                 825                 830         


Gln Asp Ile Thr Leu Tyr Leu Trp Thr Arg Leu Phe Ile Glu Glu Asn 
        835                 840                 845             


Pro Glu Gln Ile Phe Phe Ser Lys Asn Glu Lys Pro Glu Asn Ser Leu 
    850                 855                 860                 


Phe Lys Leu Arg Glu Met Asn Asn Ala Ile Leu Asp Asn Thr Thr Ser 
865                 870                 875                 880 


Arg Lys Ile Asn Ile Asn Thr Pro Asn Gly Asn Val Ser Ile Glu Asp 
                885                 890                 895     


Glu Phe Lys Ile Lys Asp Tyr Gly Arg Val Thr Ala Leu Thr Thr Glu 
            900                 905                 910         


Lys Leu Pro Gln Ser Leu Ile Lys Phe Ile Ala Ile Leu Asn Lys Pro 
        915                 920                 925             


Leu Asn Lys Lys Asp Arg Pro Leu Leu Ser Tyr Asp Tyr Ile Tyr His 
    930                 935                 940                 


Glu Thr Asn Ala Phe Tyr Arg Tyr Arg Pro Glu Ile Ile Lys Met Ala 
945                 950                 955                 960 


Gln Asp Ile Glu Asn Lys Ile Ile Asn Asp Leu Lys Ile Asn Val Lys 
                965                 970                 975     


Pro Gln Ala Glu Ser Tyr Tyr Asn Phe Arg Arg Thr Ile Gln Lys Leu 
            980                 985                 990         


Glu Asn Lys Ser Arg Asp Ile Asn  Ile Glu Leu Leu Ile  Lys Ile Arg 
        995                 1000                 1005             


Asn Ala  Phe Cys His Asn Glu  Tyr Lys Glu Leu Asp  Asn Asp Gln 
    1010                 1015                 1020             


Tyr Lys  Tyr Leu Asn Ser Leu  Phe Lys Leu Ser Ser  Asp Ile Lys 
    1025                 1030                 1035             


Gln Thr  Asp Thr Leu Ala Tyr  Leu Leu Tyr Ile Leu  Phe Glu Thr 
    1040                 1045                 1050             


Glu Tyr  Gln Lys Val Met Ile  Leu Lys 
    1055                 1060         


<210>  1355
<211>  1047
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1355

Met Glu Thr Glu Val Thr Ala Gln Asn Asn Ser Leu Thr Leu Thr Asn 
1               5                   10                  15      


Asn Pro Tyr Tyr Phe Ala His Tyr Ala Asn Met Ala Arg His Asn Ala 
            20                  25                  30          


Tyr Ile Val Leu Asn Glu Ile Asn Glu Lys Ile Tyr Asn Asn Lys Val 
        35                  40                  45              


Lys Ile Pro Glu Asp Gly Leu Ser Glu Cys Lys Leu Val Asn Ser Phe 
    50                  55                  60                  


Ser Lys Lys Asn Lys Lys Ala Asp Glu Tyr Ala Arg Ile Ile Lys Leu 
65                  70                  75                  80  


Leu Thr Glu His Tyr Pro Phe Ile Arg Phe Tyr Ala Asp Ser Ser Lys 
                85                  90                  95      


Glu Met Gly Asn Ile Pro Leu Lys Ala Tyr Leu Asp Ile Leu Asp Lys 
            100                 105                 110         


Ile Arg Asn Glu Asn Asn His Tyr Asn His Thr Ala Glu Arg Lys Glu 
        115                 120                 125             


Ile Ser Lys Ile Gln Glu Leu Phe Leu Phe Ala Lys Glu Lys Ala Lys 
    130                 135                 140                 


Gly Arg Met Ile Glu Phe Ser Pro Glu Asp Phe Asp His Leu Asn Asn 
145                 150                 155                 160 


Ser Lys Tyr Tyr Ala Met Thr Glu Asp Gly Ser Leu Thr Asn Thr Gly 
                165                 170                 175     


Ile Tyr Phe Phe Leu Cys Leu Phe Leu Glu Lys Lys His Ala Phe Gln 
            180                 185                 190         


Phe Leu Ser Arg Ile Lys Gly Phe Lys His Arg Glu Gln Lys Ser His 
        195                 200                 205             


Arg Ala Thr Leu Glu Thr Phe Thr Gln Leu Cys Cys Arg Leu Pro Tyr 
    210                 215                 220                 


Pro Lys Leu Glu Ser Ser Asp Val Ala Leu Asp Met Leu Asn Glu Ile 
225                 230                 235                 240 


Ala Arg Cys Pro Asn Ala Leu Tyr Gly Val Leu Glu Asn Lys Asp Lys 
                245                 250                 255     


Glu Thr Phe Lys Val Glu Phe Lys Asn Gly Ala Thr Asn Asn Glu Met 
            260                 265                 270         


Glu Val Pro Glu Pro Val Met Lys Arg His Asp Asp Arg Phe Pro Tyr 
        275                 280                 285             


Phe Ala Leu Arg Tyr Phe Asp Lys Ser Gln Ala Leu Asp Gly Ile Thr 
    290                 295                 300                 


Ser His Leu Gln Leu Gly Arg Arg Ile Val Ser Asp Pro His Gln Lys 
305                 310                 315                 320 


Lys Ile Gly Ala Glu Val Arg Thr His Glu Ile Leu Lys Asp Met Arg 
                325                 330                 335     


Thr Ala His Gln Leu Ala Tyr Phe Glu Thr Asp Ala Ala Lys Glu Phe 
            340                 345                 350         


Tyr Thr Asn Ile Pro Val Val Glu His Tyr Ala Pro Gln Tyr Arg Ile 
        355                 360                 365             


Val Gly Asn Arg Ile Gly Leu Phe Phe Asp Tyr Glu Cys Trp Gly Lys 
    370                 375                 380                 


Tyr Thr Val Pro Lys Glu Asn Val Lys Pro Asp Ala Ile Ile Ser Ile 
385                 390                 395                 400 


His Asp Leu Gly Ala Leu Tyr Phe Tyr Asn Arg Leu Tyr Lys Glu Gly 
                405                 410                 415     


Ser Val Lys Gln Ser Pro Lys Glu Leu Met Lys Ser Tyr Leu Glu Asn 
            420                 425                 430         


Met Asn Arg Leu Phe Asp Asp Val Lys Lys Gly Asn Ile Lys Pro Val 
        435                 440                 445             


Asn Asp Gly Glu Lys Leu Thr Pro Leu Phe Lys Ile Lys Asp Lys Glu 
    450                 455                 460                 


Asp Glu Tyr Glu Ile Arg Leu Glu Asn Leu Lys Glu Leu Ser Ala Leu 
465                 470                 475                 480 


Leu Gln Thr Glu Leu Asp Lys Arg Gly Tyr Gly Ile Glu Val Lys Asn 
                485                 490                 495     


Leu Pro Asp Val Cys Arg Glu Tyr Leu Leu Gly Tyr Lys Glu Ser Ser 
            500                 505                 510         


Ala Lys Asp Lys Ala Lys Arg Arg Phe Lys Arg Met Leu Arg Glu Thr 
        515                 520                 525             


Gln Phe Ala Leu Lys Lys Val Glu Arg Val Leu Ile Gln Glu Thr Ser 
    530                 535                 540                 


Leu Leu Ala Ser Gly Leu Lys Val Gly Glu Met Ala Gln Glu Leu Ala 
545                 550                 555                 560 


Arg Asp Ile Val Phe Leu Ile Lys Pro Lys Ile Val Lys Lys Ile Ile 
                565                 570                 575     


Lys Ser Gly Thr Asp Ala Gly Lys Glu Val Glu Cys Lys Gln Lys Ile 
            580                 585                 590         


Asn Asn Met Glu Phe Asp Val Leu Gln Lys Met Leu Ala Phe Tyr Pro 
        595                 600                 605             


Val Tyr Lys Glu Glu Ile Glu His Phe Leu Trp Thr Met Val Asn Lys 
    610                 615                 620                 


Arg Asp Pro Asn Ala Phe Ser His Pro Phe Leu Phe Arg Ala Leu Leu 
625                 630                 635                 640 


Lys Ile Lys Thr Cys Arg Asn Leu Asn Asp Phe Tyr Lys Glu Tyr Tyr 
                645                 650                 655     


Leu His Lys Gln Arg Trp Ile Glu Gly Val Ser Lys Ser Ile Thr Pro 
            660                 665                 670         


Glu Val Leu Arg Asp Asn Glu Tyr Phe Leu Lys Leu Glu Asn Gly Asn 
        675                 680                 685             


Ala Phe Pro His Asn Tyr Asn Gly Glu Ala Ile Phe Ile Pro Ser Gly 
    690                 695                 700                 


Phe Phe Asn Lys Glu Ile Thr Arg Ala Met Val Gln Ile Gly Tyr Lys 
705                 710                 715                 720 


Ile Glu Asn Pro Glu Lys Gly Ala Asn Ala Ala Tyr Trp Ile Lys Gln 
                725                 730                 735     


Tyr Phe Glu Gly Lys Ser Gln Pro Phe Tyr Asn Leu Pro Arg Tyr Tyr 
            740                 745                 750         


Asn Glu Ser Leu Gly Gly Lys Glu Pro Val Tyr Ile Glu Arg Asp Lys 
        755                 760                 765             


Leu Lys Lys Gln Ile Leu Glu Gly Asp Phe Asn Arg Leu Thr Glu Asp 
    770                 775                 780                 


Glu Gln Lys Arg Arg Lys Val Leu Ala Lys Arg Ile Arg Glu Asn Glu 
785                 790                 795                 800 


Ser Glu Ile Leu Thr Asn Gln Thr Asn Asp Arg Val Met Tyr Leu Met 
                805                 810                 815     


Ala Met Glu Leu Ile Asp Ser Glu Asn Pro Leu Lys Lys Asn Glu Ile 
            820                 825                 830         


Val Ser Val Gly Tyr Asn Ile Lys Glu Gly Thr Asn Leu Leu Asp Asn 
        835                 840                 845             


Asn Lys Val Ser Trp Asn Ile Gln Gly Arg Arg Val Val Ala Glu Leu 
    850                 855                 860                 


Pro Ile Lys Arg Tyr Gly Glu Tyr Arg Arg Phe Leu Lys Asp Arg Arg 
865                 870                 875                 880 


Leu Glu Asn Leu Leu Lys Tyr Tyr Pro Glu Gly Lys Glu Leu Gln Leu 
                885                 890                 895     


Gly Thr Leu Lys Ser Gly Glu Val Glu Glu Lys Gly Lys Lys Tyr Thr 
            900                 905                 910         


Asn Ser Asn Leu Val Asp Glu Leu Glu Leu Phe Asp Leu Lys Arg Asn 
        915                 920                 925             


Glu Leu Met Glu Gln Val Tyr Leu Phe Glu Lys Ile Leu Cys Thr Asn 
    930                 935                 940                 


Tyr Ala Asp Lys Ile Lys Ala Val Leu Pro Asp Lys Glu Arg Asn Lys 
945                 950                 955                 960 


Pro Tyr Ile Glu His Tyr His Cys Leu Met Tyr Ala Lys Asn Glu Met 
                965                 970                 975     


Lys Leu Phe Lys Glu Val Gly Glu Leu Glu His Glu His Phe Asn Glu 
            980                 985                 990         


Leu Arg Asn Lys Ile Ser His Asn  Gln Met Pro Tyr Thr  Asp Trp Leu 
        995                 1000                 1005             


Met Glu  Arg Val Ile Ala Asn  Lys Glu Glu Pro Met  Ile Thr Asn 
    1010                 1015                 1020             


Arg Ile  Val Asp Leu Ile Leu  Ser Ile Tyr Lys Glu  Leu Asn Ser 
    1025                 1030                 1035             


Gln Leu  Val Ile Ile Thr Asn  Ser Lys 
    1040                 1045         


<210>  1356
<211>  1140
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1356

Met Glu Asn Asp Gln Gln Ile Leu Glu Asn Arg Arg Arg Thr Leu Ala 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Ser Asn His Leu Ala Thr Ser Phe Glu Gln Lys Ala 
        35                  40                  45              


Leu His Glu Glu Gly Gln Ile Pro Ala Ser Phe Leu Cys Asn Lys Ser 
    50                  55                  60                  


Ile Lys Lys Ile Asn Trp Asn His Val Tyr Ser Lys Ala Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Ile Phe Asp Ala Asp Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Arg Glu Thr Ser Asp Lys Glu Gly Lys Asp Phe Thr Ala Met Asn Glu 
            100                 105                 110         


Thr Leu Lys Leu Val Phe Asp Glu Leu Gln Ala Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Ala Asp Ser Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Val Glu Leu Ala Asp Phe Leu Thr Val Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Ala Asp Asp Asp Tyr 
                165                 170                 175     


Ala Val Val Glu Ser Lys Gln Ile Val Thr Pro Asp Asn Gln Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Ile Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Val Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Leu Ala Tyr Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asp Leu Arg Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Glu 
            260                 265                 270         


Val Ile Thr Glu Glu Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Glu Glu Glu Arg 
    290                 295                 300                 


Glu Lys Ile Leu Asp Glu Ile Asp Tyr Glu Asp Tyr Ile Glu Ser Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg His Ser Asn Arg Phe Pro Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Glu Lys Tyr Asn Lys Gln Phe Asp Gly Glu 
        355                 360                 365             


Ala Thr Glu Arg Lys Val Val Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asn Gln Glu Thr Val Glu Leu Lys Ile Asp Ser Ala 
385                 390                 395                 400 


Gln Arg Thr Asn Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Glu Ala Arg Leu Leu 
            420                 425                 430         


Thr Lys Ala Lys Pro Glu Ser Lys Val Ser Tyr Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Lys Ala Glu Glu Met Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Lys Val Asn Asp Ser Gln Leu Met Asn Met Gln Phe Ile Asp Glu 
                485                 490                 495     


Ile Lys Glu Gln Leu Pro Ala Asp Trp Asn Glu Phe Gly Lys Arg Ser 
            500                 505                 510         


Asp Ser Lys Lys Lys Lys Ala Tyr Thr Asn Ala Ala Arg Gln Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Lys Val Leu Ala Asn Tyr Gln Leu 
    530                 535                 540                 


Asn Asp Lys Gln Val Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Val 
545                 550                 555                 560 


Lys Glu Val Asp Asp Ser Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Met Glu Lys His Lys Val 
            580                 585                 590         


Asp Lys Ser Ala Arg Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Thr Asp Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Tyr 
625                 630                 635                 640 


Ala Asp Asn Glu Lys Lys Ala Thr Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Lys Asp Gly His Pro Phe Leu Ala Asn Ile Asn 
            660                 665                 670         


Leu Arg Gln Ile Arg Lys Thr Ser Gln Leu Tyr Glu Leu Tyr Leu Val 
        675                 680                 685             


Glu Lys Ala Asn Lys Gln Val Lys Lys Met Asn Pro Lys Thr Gln Arg 
    690                 695                 700                 


Thr Asn Asn Val Asp Glu Ser Trp Met Met Lys Ser Phe Tyr Ala Lys 
705                 710                 715                 720 


Glu Trp Asn Glu Glu Met Gly Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Thr Asn Ile Pro Phe Thr Ile Arg Gln Trp Glu Glu Lys 
            740                 745                 750         


Glu Lys His Asn Leu Gln Ala Trp Leu His Asn Ile Thr Lys Gly Lys 
        755                 760                 765             


Thr Ser Lys Asp Gly Lys Lys Ala Val Asp Leu Pro Thr Asn Leu Phe 
    770                 775                 780                 


Asp Asp Thr Leu Cys Glu Leu Leu Arg Glu Ala Leu Ile Asn Glu Gly 
785                 790                 795                 800 


Ile Asp Ala Thr Pro Thr Thr Lys Tyr Asn Glu Leu Leu Lys His Trp 
                805                 810                 815     


Trp Thr Ala Arg Glu Asp Ser Thr Gln Asp Phe Tyr Leu Ser Glu Arg 
            820                 825                 830         


Gln Tyr Asp Ile Tyr Asp Glu Lys Val Cys Phe Thr Ile Asn Ser Ser 
        835                 840                 845             


Ala His Phe Ala Asp Tyr Tyr Ala Pro Ala Leu Ser Lys Ala Tyr Ser 
    850                 855                 860                 


Arg Leu Arg Ala Glu Arg Asp Val Ala Arg Arg Thr Asp Lys Arg Leu 
865                 870                 875                 880 


Pro Pro Val Glu Arg Lys Asp Val Glu Arg Val Phe Lys Asn Thr Ile 
                885                 890                 895     


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
            900                 905                 910         


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asn Gln Gln Gln Leu Lys 
        915                 920                 925             


Leu Ser Lys Met Asp Ser Leu Leu Asn Glu Thr Lys Arg Ile Glu Gln 
    930                 935                 940                 


Val Ile Asn Thr Gln Leu Ser Phe Asp Gln Lys Gly Lys Glu Ile Lys 
945                 950                 955                 960 


Asp Lys Thr Asn Leu Glu Ile Val Lys Thr Ile Val Ala Glu Arg Lys 
                965                 970                 975     


Gln Lys Asn Tyr Thr Glu Met Arg Lys Tyr Val His Asp Arg Arg Leu 
            980                 985                 990         


Pro Glu Leu Phe Glu Tyr Ile Asp  Gly Asn Glu Leu Pro  Leu Asp Met 
        995                 1000                 1005             


Leu Leu  Asn Glu Leu Arg Ala  Tyr Asn Thr Ala Lys  Gln Val Val 
    1010                 1015                 1020             


Phe Asp  Thr Val Phe Ala Leu  Glu Lys Lys Ile Ile  Glu Thr Asp 
    1025                 1030                 1035             


Pro Glu  Gly Leu Lys Gln Leu  Asn Val Ser Lys Asp  Gly Gln Ile 
    1040                 1045                 1050             


Gln Thr  Gly Asn Ile Gln His  Lys Pro Tyr Val Gln  Trp Leu Glu 
    1055                 1060                 1065             


Asn Lys  Gly Leu Ile Thr Asp  Lys Asp Lys Gln Phe  Ile Asn Met 
    1070                 1075                 1080             


Val Arg  Asn Ser Phe Ser His  Asn Gln Phe Pro Gln  Arg Ser Thr 
    1085                 1090                 1095             


Val Glu  Leu Leu Met Pro Val  Trp Gln Asn Thr Asn  Ile Ala Leu 
    1100                 1105                 1110             


Gln Ile  Ala Arg Glu Tyr Gln  Gln Leu Ile Val Asp  Ile Ile Glu 
    1115                 1120                 1125             


Lys Ser  Leu His Pro His Lys  Gln His Gln Met Val  
    1130                 1135                 1140 


<210>  1357
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1357

Met Glu Thr Lys Gln Gln Val Gly Lys Gly Ile Ser Tyr Asp His Arg 
1               5                   10                  15      


Arg Pro Asp Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asp Gly Val Ile Gln Glu Phe Ala Met Arg Leu Asn Arg 
        35                  40                  45              


Glu Tyr Asp Pro Glu Asn Lys Asn Gln Ser Leu Phe Ser Tyr Phe Asn 
    50                  55                  60                  


Ile Asn Ala Ser Phe Thr Asp Trp Glu Arg Gly Val Asn Ile Leu Lys 
65                  70                  75                  80  


Glu Tyr Trp Pro Met Met Glu Phe Ile Asp Arg Pro Ala Thr Asp Lys 
                85                  90                  95      


Gln Phe Glu Ala Glu Lys Pro Glu Asn Arg Glu Ala Ala Lys Arg Lys 
            100                 105                 110         


Tyr Phe Leu Ala Thr Leu Gly Ala Leu Leu Thr Ser Ile Lys Asp Leu 
        115                 120                 125             


Arg His Tyr Tyr Thr His Tyr Tyr His Pro Pro Val His Leu Asn Asp 
    130                 135                 140                 


Asp Leu Phe Leu Phe Leu Asp His Ala Leu Leu Tyr Thr Ala Phe Asp 
145                 150                 155                 160 


Val Lys Lys Thr Lys Met Lys Asp Asp Lys Thr Arg Gln Leu Leu Asn 
                165                 170                 175     


Gln Asn Leu Ser Leu Glu Leu Glu Lys Leu Lys Lys Leu Lys Val Glu 
            180                 185                 190         


Glu Leu Lys Lys Lys Lys Glu Lys Gly Ile Lys Val Asn Leu Gln Asp 
        195                 200                 205             


Glu Lys Gly Ile Leu Asn Ala Ile Tyr Asn Asp Ala Phe Ala His Ile 
    210                 215                 220                 


Ile Thr Lys Glu Lys Asp Ser Asp Lys Asp Lys Leu Glu Thr Arg Tyr 
225                 230                 235                 240 


Lys Ser Ile Leu Pro Gln Asp Glu Ala Ala Glu Thr Gly Ile Asn Ile 
                245                 250                 255     


Ser Ile Ser Gly Leu Ile Phe Leu Leu Ser Leu Phe Leu Ser Arg Lys 
            260                 265                 270         


Glu Ile Glu Gln Leu Lys Ser Asn Ile Glu Gly Tyr Lys Gly Lys Val 
        275                 280                 285             


Leu Asn Ile Glu Thr Glu Val Asp Arg Lys His Asn Ser Leu Lys Tyr 
    290                 295                 300                 


Met Ala Thr His Trp Val Phe Ser Ile Leu Ala Phe Lys Gly Leu Lys 
305                 310                 315                 320 


Gln Arg Leu Thr Asn Ser Phe Glu Lys Glu Ser Leu Leu Ile Gln Met 
                325                 330                 335     


Met Asp Glu Leu Asn Lys Val Pro Asp Glu Leu Tyr Gln Thr Leu Ser 
            340                 345                 350         


Glu Thr Ala Lys Lys Glu Phe Leu Glu Asp Ile Asn Glu Tyr Val Ser 
        355                 360                 365             


Glu Gly Asp Asp Asn Glu Lys Ala Thr Tyr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Ser Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gln Phe Pro Thr Leu Lys Phe Gln Ile Phe Val Gly 
                405                 410                 415     


Gln Tyr Leu His Asp Asn Arg Pro Lys Thr Leu Ala Ser Asn Gly Met 
            420                 425                 430         


Thr Ala Gln Arg Met Ile Lys Glu Lys Ile Asn Leu Phe Gly Asn Leu 
        435                 440                 445             


Ser Glu Val Thr Lys His Lys Ser Asp Phe Phe Glu Lys Glu Ser Ala 
    450                 455                 460                 


Ala Gln Gly Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Trp Ala Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Val Tyr Ile Asp Met Ile Gly Lys Glu Gly Lys Ala 
                485                 490                 495     


Lys Glu Ile Gln Val Gln Ile Asn Lys Tyr Arg Lys Gln Leu Asn Pro 
            500                 505                 510         


Ala Pro Gln Arg Asp Lys Arg Ile Ser Lys Lys Glu Ile Ile Glu Gln 
        515                 520                 525             


Leu Tyr Lys Glu Lys Val Val Tyr Gly Asp Pro Thr Leu Met Leu Ser 
    530                 535                 540                 


Ala Asn Glu Leu Met Ala Leu Leu Tyr Glu Leu Ile Val Asn Gly Lys 
545                 550                 555                 560 


Ser Gly Ala Glu Leu Glu Asn Lys Ile Val Glu Gln Ile Ile Ala Arg 
                565                 570                 575     


Tyr Glu Gln Ile Glu Ala Tyr Asp Pro Thr Thr Gln Gln Leu Pro Thr 
            580                 585                 590         


Asn Gln Met Pro His Lys Leu Gln Lys Ser Arg Lys Asp Ser Lys Val 
        595                 600                 605             


Thr Asp Thr Asp Lys Leu Leu Lys Thr Ile Asp Lys Glu Ile Asp Glu 
    610                 615                 620                 


Gly Asn Lys Lys Leu Glu Leu Ile Ala Cys His Arg Lys Glu Trp Glu 
625                 630                 635                 640 


Glu Ala Glu Gln Arg Lys Lys Ser Gly Lys Arg Asn Asn Pro Gly Thr 
                645                 650                 655     


Lys Ser Arg Lys His Leu Phe Tyr Ala Ser Glu Met Gly Glu Glu Ala 
            660                 665                 670         


Thr Trp Ile Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Pro Ala Arg 
        675                 680                 685             


Ala Glu Trp Lys Gly Thr His His Ser Glu Leu Gln Arg Leu Leu Ala 
    690                 695                 700                 


Phe Tyr Ser Thr Gln Arg Leu Glu Ala Trp Gln Leu Val Glu Ser Val 
705                 710                 715                 720 


Trp Thr Ala Asn Thr His Ser Phe Trp Glu Glu Asn Phe Lys Glu Ala 
                725                 730                 735     


Phe Tyr Lys Pro Glu Phe Glu Asn Phe Tyr Gly Ala Tyr Ile Glu Ile 
            740                 745                 750         


Arg Thr Lys Ile Leu Thr Thr Cys Arg Ser Ile Leu Glu Asn Asn Pro 
        755                 760                 765             


Glu Ala Thr Met Asn Asn Asp Thr Glu Lys Glu Trp Asp Lys Val Phe 
    770                 775                 780                 


Thr Leu Phe Asp Lys Arg Leu Tyr Arg Thr Ser Thr Thr Asp Glu Gln 
785                 790                 795                 800 


Lys Lys Gln Leu Leu Thr Lys Pro Phe Ala Phe Pro Arg Gly Leu Phe 
                805                 810                 815     


Asp Asp Lys Pro Thr Phe Leu Pro Gly Ser Lys Pro Asn Glu Asn Pro 
            820                 825                 830         


Glu Arg Phe Ala Ala Trp Tyr Ser Tyr Gly Tyr Thr Tyr Ser Gly Lys 
        835                 840                 845             


Phe Gln Ser Phe Tyr Asp Met Pro Arg Asn Tyr Ser Asp Trp Tyr Lys 
    850                 855                 860                 


Lys Leu Lys Glu Asp Gly Lys Leu Pro Arg Leu Asp Lys Lys Thr Glu 
865                 870                 875                 880 


Gln Glu Lys Ile Leu Arg Phe Arg Met Asp Cys Asp Leu Asn Ile Lys 
                885                 890                 895     


His Ile Arg Phe Gln Asp Ile Tyr Val Lys Leu Met Val Asp Ser Leu 
            900                 905                 910         


Tyr Lys Ala Val Phe Gly Gln Gln Pro Glu Phe Asp Leu Ser His Leu 
        915                 920                 925             


Tyr Asp Thr Arg Ser Glu Arg Tyr Glu Asn Asn Thr Ile Ala Gln Arg 
    930                 935                 940                 


Gln Lys Ser Arg Gln Glu Gly Asp Asn Ser Asp Asn Ala Ile Asn Glu 
945                 950                 955                 960 


Asn Tyr Val Trp Asn Lys Thr Phe Ala Ile Ser Leu Tyr Asn Gly Arg 
                965                 970                 975     


Ile Thr Glu Ser Gln Val Lys Leu Lys Asp Val Gly Lys Phe Arg Arg 
            980                 985                 990         


Phe Ala Thr Asp Pro Arg Val Gln  Thr Leu Ile Ser Tyr  Asp Asp Thr 
        995                 1000                 1005             


Arg Thr  Trp Thr Lys Leu Glu  Ile Glu Asn Glu Leu  Asp Asn Lys 
    1010                 1015                 1020             


Ala Asp  Ala Tyr Glu Pro Ile  Arg Arg Thr Gln Ser  Leu Lys Ala 
    1025                 1030                 1035             


Ile Gln  Gln Leu Glu Lys Asn  Ile Leu Lys Lys Asn  Gly Phe Asn 
    1040                 1045                 1050             


Gly Lys  Gln His Pro Glu Glu  Leu Lys His Asn Gly  Asn Pro Asn 
    1055                 1060                 1065             


Phe Arg  Lys Tyr Ile Ala Asn  Gly Leu Leu Lys His  Arg Thr Asp 
    1070                 1075                 1080             


Ile Arg  Gln Glu Glu Leu Ala  Leu Ile Ser Asp Thr  Glu Phe Gln 
    1085                 1090                 1095             


Glu Ile  Gly Leu Glu Arg Ile  Arg Gln Thr Asn Pro  Leu Ile Gln 
    1100                 1105                 1110             


Lys Ala  Tyr Leu Leu Ile Leu  Leu Arg Asn Lys Phe  Gly His Asn 
    1115                 1120                 1125             


Gln Leu  Pro Asp Gln Glu His  Phe Arg Leu Met Arg  Ser Ile Tyr 
    1130                 1135                 1140             


Pro Tyr  Asn Gln Gln Glu Ser  Tyr Ser Ala Tyr Phe  Asn His Val 
    1145                 1150                 1155             


Ile Thr  Gln Ile Ile Glu Glu  Leu Asn Thr 
    1160                 1165             


<210>  1358
<211>  1094
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1358

Met Glu Ala Asn Glu Gln Asn Gln Glu Asn Arg Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Asn Asn His Ile Ala Ala Asp Phe Gly Gln Ala Val 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ser Gly Phe Leu Cys Asn Lys Glu 
    50                  55                  60                  


Ile Lys Lys Leu Asn Trp Asn His Ile Tyr Ala Lys Thr Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ile Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Val Asn Ser Asp Lys Glu Gly Lys Asp Phe Ala Ala Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Ser Glu Leu Gln Asp Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Glu Asn Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Ala Glu Leu Thr Asp Met Leu Thr Ile Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Thr Asp Ala Asp Tyr 
                165                 170                 175     


Glu Leu Val Glu Thr Lys Gln Val Val Thr Thr Gly Asn Ile Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Met Phe Leu Glu Arg Glu His 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asn Leu Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Gly 
            260                 265                 270         


Val Ile Thr Asp Glu Glu Lys Met Gln Phe Arg Pro Glu Leu Asp Glu 
        275                 280                 285             


Leu Asp Ile Glu Lys Leu Ile Ala Asn Ser Thr Asn Asp Asp Glu Arg 
    290                 295                 300                 


Glu Arg Ile Leu Asp Glu Ile Gly Tyr Glu Glu Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg Tyr Asn Asn Arg Phe Pro Tyr Phe Ala Met Arg 
                325                 330                 335     


Phe Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Arg Tyr Thr Lys Gln Leu Ala Gly Glu 
        355                 360                 365             


Gln Thr Glu Arg Val Val Gln Glu Asn Val Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asp Pro Glu Leu Ile Gln Gln Lys Ile Asp Asn Gln 
385                 390                 395                 400 


Gln Arg Thr Asp Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Ile Ala Ile Leu Ile 
            420                 425                 430         


Pro Lys Ser Lys Pro Glu Ser Lys Val Gly Asn Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Asp Tyr Leu Gln Lys Gly Lys Ala Glu Glu Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Ile Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Leu Lys Leu Pro Ala Asn Trp Asn Glu Phe Ala Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asp Ala Ala Met Glu Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Asp Val Leu Ile Thr Tyr Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Asp Val Glu Asp Asn Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Leu Glu Lys His Lys Leu 
            580                 585                 590         


Asp Lys Ser Val Lys Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Met Val Ser Lys Glu Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Ala Asp Thr Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Val Leu Glu Gly Asp Gly His Pro Phe Leu Thr Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Glu Leu Tyr Met Asn 
        675                 680                 685             


Ala Lys Val Gln Tyr Leu Ile Gln Phe Tyr Lys Pro Ser Lys Asp Lys 
    690                 695                 700                 


Val Asp Lys Arg Gly Arg Pro Thr Thr Glu Val Lys Leu Pro Pro Leu 
705                 710                 715                 720 


Asp Lys Arg Ser Asn Ile Pro Phe Thr Ile Arg Gln Trp Asp Glu Lys 
                725                 730                 735     


Glu Lys Tyr Asn Leu Asn Ala Trp Leu Arg Asn Val Thr Val Gly Lys 
            740                 745                 750         


Asn Thr Lys Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe 
        755                 760                 765             


Asp Glu Thr Leu Cys Asp Leu Leu Ser Gln Gln Leu Asp Ala Arg Thr 
    770                 775                 780                 


Val Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Leu Trp 
785                 790                 795                 800 


Trp Lys Thr Arg Asp Asp Ala Thr Gln Asp Phe Tyr Gln Ser Glu Arg 
                805                 810                 815     


Glu Tyr Asp Ile Tyr Glu Glu Lys Val Glu Phe Lys Ile Asp Ser Ser 
            820                 825                 830         


Gly His Phe Ala Asp Tyr Tyr Lys Lys Ala Leu Ser Lys Ala Tyr Asn 
        835                 840                 845             


Arg Leu Lys Ala Glu Arg Glu Ile Ala Arg Arg Thr Asn Lys Arg Leu 
    850                 855                 860                 


Pro Pro Ile Glu His Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile 
865                 870                 875                 880 


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
                885                 890                 895     


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asp Ser Gly Asn Leu Lys 
            900                 905                 910         


Leu Ser Thr Ile Lys Thr Ser Leu Asn Asn Thr Thr Gln Ile Lys Gln 
        915                 920                 925             


Lys Ile Leu Asn Lys Thr Ile Val Ala Glu Arg Lys Gln Lys Asn Tyr 
    930                 935                 940                 


Thr Glu Leu Arg Lys Tyr Val His Asp Arg Arg Leu Pro Asn Leu Phe 
945                 950                 955                 960 


Glu Tyr Val Glu Ala Asp Glu Ile Leu Leu Glu Trp Leu Leu Asp Glu 
                965                 970                 975     


Leu Met Ala Tyr Asn Ala Ala Lys Gln Gln Val Phe Asp Thr Ile Phe 
            980                 985                 990         


Met Leu Glu Lys Arg Ile Ile Glu  Thr Asp Pro Gln Glu  Leu Lys Ser 
        995                 1000                 1005             


Leu Phe  Thr Asn Glu Lys Gly  Gln Val Gln Thr Gly  Asn Ile Gln 
    1010                 1015                 1020             


His Lys  Pro Tyr Val Gln Trp  Leu Lys Asn Lys Gly  Leu Ile Asn 
    1025                 1030                 1035             


His Asn  Glu Lys Leu Phe Ile  Asn Met Val Arg Asn  Cys Phe Ser 
    1040                 1045                 1050             


His Asn  Gln Phe Pro Gln Arg  Glu Thr Met Glu Leu  Leu Ile Ser 
    1055                 1060                 1065             


Glu Trp  Gly Ala Gly Lys Ile  Ala Thr Gln Ile Leu  Thr Val Tyr 
    1070                 1075                 1080             


Asn Gln  Leu Ile Thr Asn Ile  Ile Asn Lys Ile 
    1085                 1090                 


<210>  1359
<211>  1175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1359

Met Thr Glu Gln Asn Glu Arg Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Thr His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Tyr Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Glu Lys Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Thr Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Ile Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Ala 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Leu Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Glu Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Gly Glu Ile Asp Thr Leu Asp 
    530                 535                 540                 


Arg Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Glu Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Ser Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Leu Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asn Tyr Pro Phe Asn Val Gly Asn Ile Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Asp Leu Glu Ala Trp Ser Gln Ser Thr Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Ala Gly Ile Lys Tyr Ala Ser Pro Gly Asn 
    850                 855                 860                 


Lys Lys Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Glu Thr 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Lys Ala Asp Lys Ile Asn Leu Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Ala Lys Glu His Pro Tyr Leu Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asp Ile Arg Thr 
945                 950                 955                 960 


Asp Val Gln Glu Gln Gly Ser Leu Asn Val Leu Asn His Val Lys Pro 
                965                 970                 975     


Met Arg Leu Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val 
            980                 985                 990         


His Lys Glu Glu Ala Pro Leu Ala  Thr Val Tyr Ile Glu  Glu Arg Asp 
        995                 1000                 1005             


Thr Lys  Leu Leu Lys Gln Gly  Asn Phe Lys Ser Phe  Val Lys Asp 
    1010                 1015                 1020             


Arg Arg  Leu Asn Gly Leu Phe  Ser Phe Val Asp Thr  Gly Ala Leu 
    1025                 1030                 1035             


Ala Met  Glu Gln Tyr Pro Ile  Ser Lys Leu Arg Val  Glu Tyr Glu 
    1040                 1045                 1050             


Leu Ala  Lys Tyr Gln Thr Ala  Arg Val Cys Ala Phe  Glu Gln Thr 
    1055                 1060                 1065             


Leu Glu  Leu Glu Glu Ser Leu  Leu Thr Arg Tyr Pro  His Leu Pro 
    1070                 1075                 1080             


Asp Lys  Asn Phe Arg Lys Met  Leu Glu Ser Trp Ser  Asp Pro Leu 
    1085                 1090                 1095             


Leu Asp  Lys Trp Pro Asp Leu  His Arg Lys Val Arg  Leu Leu Ile 
    1100                 1105                 1110             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1115                 1120                 1125             


Glu Ala  Val Phe Ser Ser Ile  Arg Lys Tyr Asp Pro  Ser Ser Pro 
    1130                 1135                 1140             


Asp Ala  Ile Glu Glu Arg Met  Gly Leu Asn Ile Ala  His Arg Leu 
    1145                 1150                 1155             


Ser Glu  Glu Val Lys Gln Ala  Lys Glu Thr Val Glu  Arg Ile Ile 
    1160                 1165                 1170             


Gln Ala  
    1175 


<210>  1360
<211>  1165
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1360

Met Lys Asn Gln Asn Thr Leu Pro Ser Asn Pro Thr Asp Ile Leu Lys 
1               5                   10                  15      


Asp Lys Pro Phe Trp Ala Ala Phe Phe Asn Leu Ala Arg His Asn Val 
            20                  25                  30          


Tyr Leu Thr Val Asn His Ile Asn Lys Leu Leu Asp Leu Glu Lys Leu 
        35                  40                  45              


Tyr Asn Lys Asp Lys His Lys Glu Ile Phe Glu His Glu Asp Ile Phe 
    50                  55                  60                  


Asn Ile Ser Asp Asp Val Met Asn Asp Val Asn Ser Asn Gly Lys Lys 
65                  70                  75                  80  


Arg Lys Leu Asp Ile Lys Lys Ile Trp Ala Asn Leu Asp Thr Asp Leu 
                85                  90                  95      


Thr Arg Lys Tyr Gln Leu Arg Glu Leu Ile Leu Lys His Phe Pro Phe 
            100                 105                 110         


Ile Gln Pro Ala Ile Ile Gly Ala Gln Thr Lys Glu Arg Thr Thr Ile 
        115                 120                 125             


Asp Lys Asp Lys Arg Ser Thr Ser Thr Ser Asn Asp Ser Leu Lys Pro 
    130                 135                 140                 


Thr Gly Glu Gly Asp Ile Asn Asp Pro Leu Ser Leu Ser Asn Val Lys 
145                 150                 155                 160 


Ser Ile Phe Phe Arg Leu Leu Gln Met Leu Glu Gln Leu Arg Asn Tyr 
                165                 170                 175     


Tyr Ser His Val Lys His Ser Lys Ser Ala Thr Met Pro Asn Phe Asp 
            180                 185                 190         


Glu Gly Leu Leu Lys Ser Met Tyr Asn Ile Phe Ile Asp Ser Val Asn 
        195                 200                 205             


Lys Val Lys Glu Asp Tyr Ser Ser Asn Ser Val Ile Asp Pro Asn Thr 
    210                 215                 220                 


Ser Phe Ser His Leu Ile Ser Lys Asp Glu Gln Gly Glu Ile Lys Pro 
225                 230                 235                 240 


Cys Arg Tyr Ser Phe Thr Ser Lys Asp Gly Ser Ile Asn Ala Ser Gly 
                245                 250                 255     


Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys Gln Asp Ser Ile Trp 
            260                 265                 270         


Met Gln Lys Lys Ile Pro Gly Phe Lys Lys Thr Ser Glu Asn Tyr Met 
        275                 280                 285             


Lys Met Thr Asn Glu Val Phe Cys Arg Asn His Ile Leu Leu Pro Lys 
    290                 295                 300                 


Met Arg Leu Glu Thr Val Tyr Asp Lys Asp Trp Met Leu Leu Asp Met 
305                 310                 315                 320 


Leu Asn Glu Val Val Arg Cys Pro Leu Ser Leu Tyr Lys Arg Leu Ala 
                325                 330                 335     


Pro Ala Asp Gln Asn Lys Phe Lys Val Pro Glu Lys Ser Ser Asp Asn 
            340                 345                 350         


Ala Asn Arg Gln Glu Asp Asp Asn Pro Phe Ser Arg Ile Leu Val Arg 
        355                 360                 365             


His Gln Asn Arg Phe Pro Tyr Phe Ala Leu Arg Phe Phe Asp Leu Asn 
    370                 375                 380                 


Glu Val Phe Thr Thr Leu Arg Phe Gln Ile Asn Leu Gly Cys Tyr His 
385                 390                 395                 400 


Phe Ala Ile Cys Lys Lys Gln Ile Gly Asp Lys Lys Glu Val His His 
                405                 410                 415     


Leu Thr Arg Thr Leu Tyr Gly Phe Ser Arg Leu Gln Asn Phe Thr Gln 
            420                 425                 430         


Asn Thr Arg Pro Glu Glu Trp Asn Thr Leu Val Lys Thr Thr Glu Pro 
        435                 440                 445             


Ser Ser Gly Asn Asp Gly Lys Thr Val Gln Gly Val Pro Leu Pro Tyr 
    450                 455                 460                 


Ile Ser Tyr Thr Ile Pro His Tyr Gln Ile Glu Asn Glu Lys Ile Gly 
465                 470                 475                 480 


Ile Lys Ile Phe Asp Gly Asp Thr Ala Val Asp Thr Asp Ile Trp Pro 
                485                 490                 495     


Ser Val Ser Thr Glu Lys Gln Leu Asn Lys Pro Asp Lys Tyr Thr Leu 
            500                 505                 510         


Thr Pro Gly Phe Lys Ala Asp Val Phe Leu Ser Val His Glu Leu Leu 
        515                 520                 525             


Pro Met Met Phe Tyr Tyr Gln Leu Leu Leu Cys Glu Gly Met Leu Lys 
    530                 535                 540                 


Thr Asp Ala Gly Asn Ala Val Glu Lys Val Leu Ile Asp Thr Arg Asn 
545                 550                 555                 560 


Ala Ile Phe Asn Leu Tyr Asp Ala Phe Val Gln Glu Lys Ile Asn Thr 
                565                 570                 575     


Ile Thr Asp Leu Glu Asn Tyr Leu Gln Asp Lys Pro Ile Leu Ile Gly 
            580                 585                 590         


His Leu Pro Lys Gln Met Ile Asp Leu Leu Lys Gly His Gln Arg Asp 
        595                 600                 605             


Met Leu Lys Ala Val Glu Gln Lys Lys Ala Met Leu Ile Lys Asp Thr 
    610                 615                 620                 


Glu Arg Arg Leu Glu Arg Leu Asn Lys Gln Pro Glu Gln Lys Pro Asn 
625                 630                 635                 640 


Val Ala Ala Lys Asn Thr Gly Thr Leu Leu Arg Asn Gly Gln Ile Ala 
                645                 650                 655     


Asp Trp Leu Val Lys Asp Met Met Arg Phe Gln Pro Val Lys Arg Asp 
            660                 665                 670         


Lys Glu Gly Asn Pro Ile Asn Cys Ser Lys Ala Asn Ser Thr Glu Tyr 
        675                 680                 685             


Gln Met Leu Gln Arg Ala Phe Ala Phe Tyr Thr Thr Asp Ser Tyr Arg 
    690                 695                 700                 


Leu Pro Arg Tyr Phe Glu Gln Leu His Leu Ile Asn Cys Asp Asn Ser 
705                 710                 715                 720 


His Leu Phe Leu Ser Arg Phe Glu Tyr Asp Lys Gln Pro Asn Leu Ile 
                725                 730                 735     


Ala Phe Tyr Ala Ala Tyr Leu Glu Ala Lys Leu Glu Phe Leu Asn Glu 
            740                 745                 750         


Leu Gln Pro Gln Asn Trp Ala Ser Asp Asn Tyr Phe Leu Leu Leu Arg 
        755                 760                 765             


Ala Pro Lys Asn Asp Arg Gln Lys Leu Ala Glu Gly Trp Lys Asn Gly 
    770                 775                 780                 


Phe Asn Leu Pro Arg Gly Leu Phe Thr Glu Lys Ile Lys Thr Trp Phe 
785                 790                 795                 800 


Asn Glu His Lys Thr Ile Val Asp Ile Ser Asp Cys Asp Ile Phe Lys 
                805                 810                 815     


Asn Arg Val Gly Gln Val Ala Arg Leu Ile Pro Val Phe Phe Asp Lys 
            820                 825                 830         


Lys Phe Lys Asp His Ser Gln Pro Phe Tyr Thr Tyr Asn Phe Asn Val 
        835                 840                 845             


Gly Asn Val Ser Lys Ile Thr Glu Ala Asn Tyr Leu Ser Lys Glu Lys 
    850                 855                 860                 


Arg Glu Asn Leu Phe Lys Ser Tyr Gln Asn Lys Phe Lys Asn Asn Ile 
865                 870                 875                 880 


Pro Ala Glu Lys Thr Lys Glu Tyr Arg Glu Tyr Lys Asn Phe Ser Ser 
                885                 890                 895     


Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys Asn Gln Asp Ile 
            900                 905                 910         


Leu Thr Trp Leu Met Cys Lys Asn Leu Phe Asp Glu Lys Ile Lys Pro 
        915                 920                 925             


Lys Lys Asp Ile Leu Glu Pro Arg Ile Ala Val Ser Tyr Ile Lys Leu 
    930                 935                 940                 


Asp Ser Leu Gln Thr Asn Thr Ser Thr Ala Gly Ser Leu Asn Ala Leu 
945                 950                 955                 960 


Ala Lys Val Val Pro Met Thr Leu Ala Ile His Ile Asp Ser Pro Lys 
                965                 970                 975     


Pro Lys Gly Lys Ala Gly Asn Asn Glu Lys Glu Asn Lys Glu Phe Thr 
            980                 985                 990         


Val Tyr Ile Lys Glu Glu Gly Thr  Lys Leu Leu Lys Trp  Gly Asn Phe 
        995                 1000                 1005             


Lys Thr  Leu Leu Ala Asp Arg  Arg Ile Lys Gly Leu  Phe Ser Tyr 
    1010                 1015                 1020             


Ile Glu  His Asp Asp Ile Asn  Leu Glu Lys Tyr Pro  Leu Thr Lys 
    1025                 1030                 1035             


Tyr Gln  Val Asp Ser Glu Leu  Asp Leu Tyr Gln Lys  Tyr Arg Ile 
    1040                 1045                 1050             


Asp Ile  Phe Lys Gln Thr Leu  Asp Leu Glu Ala Gln  Leu Leu Asp 
    1055                 1060                 1065             


Lys Tyr  Ser Asp Leu Asn Thr  Asp Asn Phe Asn Gln  Met Leu Ser 
    1070                 1075                 1080             


Gly Trp  Ser Glu Lys Glu Gly  Ile Pro Arg Asn Ile  Lys Gln Asp 
    1085                 1090                 1095             


Val Ala  Phe Leu Ile Gly Val  Arg Asn Gly Phe Ser  His Asn Gln 
    1100                 1105                 1110             


Tyr Pro  Asp Ser Lys Arg Ile  Ala Phe Ser Arg Ile  Lys Lys Phe 
    1115                 1120                 1125             


Asn Pro  Lys Thr Ser Ser Leu  Gln Glu Ser Glu Gly  Leu Asn Ile 
    1130                 1135                 1140             


Ala Lys  Gln Met Tyr Glu Glu  Ala Gln Gln Val Val  Asn Lys Ile 
    1145                 1150                 1155             


Lys Asn  Ile Glu Ser Phe Asp  
    1160                 1165 


<210>  1361
<211>  1011
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1361

Met Thr Glu Gln Asn Glu Arg Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Phe Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Ala His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Asn Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Tyr Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Gly Thr Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Ser Glu Thr Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Phe Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Asp Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Gly Glu Ile Asp Thr Leu Asp 
    530                 535                 540                 


Arg Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Lys Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Ser Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Leu Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Asp Leu Glu Ala Trp Ala His Ser Ala Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Val Gly Ile Glu Tyr Ala Ser Arg Glu Asn 
    850                 855                 860                 


Lys Lys Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Glu Thr 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Lys Thr Asp Lys Ile Asn Ile Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Thr Lys Glu His Pro Tyr Leu Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asn Ile Arg Thr 
945                 950                 955                 960 


Asp Val Gln Glu Gln Gly Ser Leu Asn Val Leu Asn His Val Lys Pro 
                965                 970                 975     


Met Ala Cys Pro Trp Ser Cys Thr Glu Pro Thr Ala Glu Ala Met Tyr 
            980                 985                 990         


Thr Arg Ser Arg Leu Leu Trp Arg  Arg Ser Ile Ser Lys  Lys Gly Thr 
        995                 1000                 1005             


Pro Ser  Cys 
    1010     


<210>  1362
<211>  1119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1362

Met Thr Glu Gln Asn Glu Arg Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Thr His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Tyr Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Glu Lys Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Thr Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Ile Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Leu Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Glu Glu Val 
            500                 505                 510         


Ser Ala Glu Lys Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Gly Glu Ile Asp Thr Leu Asp 
    530                 535                 540                 


Arg Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Glu Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Ser Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Tyr Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Leu Ala Lys Leu Lys Lys Glu Ile Leu Glu Ala 
        835                 840                 845             


Lys Glu His Pro Tyr His Asp Phe Lys Ser Trp Gln Lys Phe Glu Arg 
    850                 855                 860                 


Glu Leu Arg Leu Val Lys Asn Gln Asp Ile Ile Thr Trp Met Met Cys 
865                 870                 875                 880 


Arg Asp Leu Met Glu Glu Asn Lys Val Glu Gly Leu Asp Thr Gly Thr 
                885                 890                 895     


Leu Tyr Leu Lys Asp Ile Arg Thr Glu Val Gln Glu Gln Gly Ser Leu 
            900                 905                 910         


Asn Val Leu Ser His Val Lys Pro Met Arg Leu Pro Val Val Val Tyr 
        915                 920                 925             


Arg Ala Asp Ser Arg Gly His Val His Lys Glu Glu Ala Pro Leu Ala 
    930                 935                 940                 


Thr Val Tyr Ile Glu Glu Arg Asp Thr Lys Leu Leu Lys Gln Gly Asn 
945                 950                 955                 960 


Phe Lys Ser Phe Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe 
                965                 970                 975     


Val Asp Thr Gly Gly Leu Ala Met Glu Gln Tyr Pro Ile Ser Lys Leu 
            980                 985                 990         


Arg Val Glu Tyr Glu Leu Ala Lys  Tyr Gln Thr Ala Arg  Val Cys Ala 
        995                 1000                 1005             


Phe Glu  Gln Thr Leu Glu Leu  Glu Glu Ser Leu Leu  Thr Arg Tyr 
    1010                 1015                 1020             


Pro His  Leu Pro Asp Lys Asn  Phe Arg Lys Met Leu  Glu Ser Trp 
    1025                 1030                 1035             


Ser Asp  Pro Leu Leu Asp Lys  Trp Pro Asp Leu Gln  Arg Glu Val 
    1040                 1045                 1050             


Arg Leu  Leu Ile Ala Val Arg  Asn Ala Phe Ser His  Asn Gln Tyr 
    1055                 1060                 1065             


Pro Met  Tyr Asp Glu Thr Leu  Phe Ser Ser Ile Arg  Lys Tyr Asp 
    1070                 1075                 1080             


Pro Ser  Ser Pro Asp Ala Ile  Glu Glu Arg Met Gly  Leu Asn Ile 
    1085                 1090                 1095             


Ala His  Arg Leu Ser Glu Glu  Val Lys Gln Ala Lys  Glu Met Ala 
    1100                 1105                 1110             


Glu Arg  Ile Ile Gln Ala 
    1115                 


<210>  1363
<211>  1199
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1363

Met Asn Thr Phe Ile Asp Ser Phe Ile Arg Arg Val Gln Ile Gln Asn 
1               5                   10                  15      


Gln Asn Gln Ser Trp Pro Lys Arg Pro Lys Tyr Val Arg Pro Val Glu 
            20                  25                  30          


Asn Ile Arg Pro Asp Asp Leu Ala Phe Gln Ser His Phe Thr Ala Tyr 
        35                  40                  45              


Leu Asn Met Ala Arg Gln Asn Cys Cys Ile Ile Leu Gly His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Gly Phe Lys Ala Ser Ser Val Lys Asp Thr Thr Leu Thr 
65                  70                  75                  80  


Ser Ser Pro Leu Leu Gly Gln Asn Gly Leu Leu Ser Pro Lys Lys Glu 
                85                  90                  95      


Val Ser Asp Leu Ile Arg Gly Arg Leu Leu Ser Ala Phe Pro Met Leu 
            100                 105                 110         


Asp Pro Met Ile Arg Tyr Arg Lys Ala Val Asp Lys Glu Lys Asp Asp 
        115                 120                 125             


Tyr Ala Arg Ile Ile Ile Thr Ser Glu Asp Val Ser Glu Met Leu Arg 
    130                 135                 140                 


Asp Leu Leu Asp Val Leu Ser Tyr Tyr Arg Asp Met Ala Ser His Val 
145                 150                 155                 160 


Val Phe Asn Asp Asp Arg Ser Val Ser Ala Glu Phe Ala Ser Lys Glu 
                165                 170                 175     


Lys Lys Val Ala Glu Cys Leu Asn Tyr Met Met Thr Val Ser Leu Arg 
            180                 185                 190         


Ile Val Lys Asp Arg Phe Ser Leu Ala Val Ser Asp Leu Asp Phe Tyr 
        195                 200                 205             


Asn Arg Asn Arg Tyr Met Met Val Asn Arg Lys Pro Leu Leu Asn Ala 
    210                 215                 220                 


Gly Phe Ala His Ala Val Arg Thr Glu Asp Tyr Arg Leu Thr Leu Met 
225                 230                 235                 240 


Gly Leu Val Leu Leu Cys Cys Gln Phe Ile Glu Lys Gln Tyr Ala Ser 
                245                 250                 255     


Met Phe Phe Asp Ala Leu Asp Lys His Ser Asn Gly Ala Arg Phe Tyr 
            260                 265                 270         


Gly Ile Ala Asp Ala Met Pro Met Val Asn Val Gly Thr Lys Asp Lys 
        275                 280                 285             


Pro Lys Lys Ile Pro Met Tyr Thr Gly Asp Glu Ala Gln Lys Gln Val 
    290                 295                 300                 


Gln Lys Gln Arg Met Ala Leu Arg Glu Ala Tyr Ser Val Tyr Arg Val 
305                 310                 315                 320 


Arg Ile Pro Lys Glu Arg Leu Glu Ser Thr Arg Ser Asp Met Ala Leu 
                325                 330                 335     


Ala Leu Asp Ile Leu Asn Glu Leu Gly Lys Cys Pro Glu Glu Leu Phe 
            340                 345                 350         


Glu His Leu Ser Pro Glu Asp Arg Glu Ser Phe Lys Asn Glu Glu Gly 
        355                 360                 365             


Val Leu Met Lys Arg Tyr Ser Asp Arg Phe Pro Gln Leu Ala Leu Arg 
    370                 375                 380                 


Trp Leu Asp Glu Asn Glu Lys Phe Asn Asn Leu Arg Phe His Val Thr 
385                 390                 395                 400 


Phe Gly Lys Tyr Arg Trp Leu Phe Cys Gln Asp Lys Lys Cys Ala Asp 
                405                 410                 415     


Gly Ser Val Arg Pro Arg Trp Leu Gln Lys Glu Leu Asn Gly Phe Gly 
            420                 425                 430         


Arg Ile Gln Thr Val Glu Arg Lys Arg Thr Gly Leu Glu Pro Gly Trp 
        435                 440                 445             


Asp Gly Thr Gly Leu Ile Arg Lys Phe Glu Glu Val Val Thr Asp Glu 
    450                 455                 460                 


Val Gln Lys Glu Pro Tyr Ile Thr Asp Phe Arg Thr Gln Tyr Leu Phe 
465                 470                 475                 480 


Asn Arg Asp Lys Ile Gly Ile Ser Leu Ser Glu Tyr Met Pro Gly Ile 
                485                 490                 495     


Gly Asp Ile His Ser Gly Lys Glu Trp Gly Lys His Ala Gly Val Pro 
            500                 505                 510         


Asp Phe Tyr Leu Ser Val Tyr Asp Ile Pro Ala Met Leu Phe Leu Thr 
        515                 520                 525             


Trp Leu Leu Gly Lys Asn Ser Ser Ala Val Glu Lys Leu Leu Ala Asn 
    530                 535                 540                 


Cys Lys Ala Ala Tyr Met Lys Leu Phe Asp Asp Leu Ala Lys Gly Lys 
545                 550                 555                 560 


Trp Glu Gly Glu Arg Asn Val Ser Asp Tyr Cys Ala Gly Glu Gly Thr 
                565                 570                 575     


Val Arg Tyr Thr Leu Arg Trp Tyr Asp Val Pro Met Lys Ile Arg Arg 
            580                 585                 590         


Lys Met Pro Leu Leu Gly Gly Asp Arg Asp Phe Glu Glu Lys Lys Ser 
        595                 600                 605             


Phe Glu Thr Leu Ala Gln Glu Ala Leu Thr Arg Met Leu Gln Arg Thr 
    610                 615                 620                 


Glu Asn Gln Leu Glu Lys Phe Asp Arg Asp Leu Ala Ala Ala Arg Asp 
625                 630                 635                 640 


Leu Lys Ala Asn Lys Gln Gly Lys Asp Arg Phe Val Asp Ile Arg Ala 
                645                 650                 655     


Gly Ser Leu Ala Thr Phe Leu Ala Arg Asp Ile Val Arg Leu Met Pro 
            660                 665                 670         


Val Ser Asp Asn Gly Arg Asn Lys Pro Thr Gly Leu Asn Tyr Ser Ile 
        675                 680                 685             


Val Gln Lys Ala Ile Ala Thr Tyr Lys Pro Ser Glu Gly Gly Leu Asp 
    690                 695                 700                 


Thr Leu Thr Gly Val Phe Arg Asp Ala Arg Ile Ile Gly Val Lys Gly 
705                 710                 715                 720 


Gly Ser His Pro Phe Leu Glu Arg Leu Leu Val Glu Lys Lys Pro Ser 
                725                 730                 735     


Ser Val Leu Ala Leu Tyr Arg His Tyr Leu Glu Tyr Arg Lys Glu Tyr 
            740                 745                 750         


Leu Lys Lys Ala Leu Glu Asp Glu Asn Lys Ala Glu Leu Lys Asn Leu 
        755                 760                 765             


Pro Phe Leu Lys Ser Gly Arg Gln Lys Tyr Ala Val Asp Gln Ala Asp 
    770                 775                 780                 


Tyr Ala Arg Arg Leu Ala Glu Ser Tyr Arg Asn Cys Pro Ile Tyr Leu 
785                 790                 795                 800 


Pro Thr Gly Ile Phe Thr Asp Met Leu Lys Asp Gln Leu Ala Lys Ile 
                805                 810                 815     


Asp Val Met Lys Pro Val Leu Glu Asn Asp Lys Val Asn Ala Ser Tyr 
            820                 825                 830         


Leu Ile Ala Gln Tyr Phe Glu Lys Val Glu His Asp Ser Glu Gln Pro 
        835                 840                 845             


Leu Tyr Arg Leu Lys Arg Asn Tyr Arg Val Phe Asp Leu Leu Glu Phe 
    850                 855                 860                 


Thr Asp Glu Pro Lys Tyr Trp Arg Leu Asn Glu Arg Ser Asp Lys Ala 
865                 870                 875                 880 


Gly Lys Tyr Gly Leu Ala Lys Arg Asn Ile Phe Trp Asn Arg Met Gly 
                885                 890                 895     


Glu Tyr Tyr Lys Gly Leu Lys Lys Phe Tyr Lys Gly Tyr Glu Ser Lys 
            900                 905                 910         


Arg Thr Ala Val Asp Trp Arg Glu Lys Leu Lys Ile Val Glu Ala Glu 
        915                 920                 925             


His Ala Met Trp Asn Arg Leu Lys Asp Ala Ser Gly Glu Ala Arg Leu 
    930                 935                 940                 


Lys Met Lys Asp Gly Val Phe Tyr Ser Arg Leu Leu Ser Ala Arg Lys 
945                 950                 955                 960 


Glu Tyr Asp Asp Cys Glu Arg Ala Leu Arg Arg Leu Lys Val Gln Asp 
                965                 970                 975     


Ile Val Leu Phe Leu Ala Ala Arg Glu Thr Leu Ile Leu Pro Lys Asp 
            980                 985                 990         


Lys Val Phe Arg Leu Lys Asn Leu  Ser Leu Ser Glu Gly  Asn Lys Asn 
        995                 1000                 1005             


Ile Leu  Ser Ser Ala Ile Asp  Glu Phe Ser Val Asp  Val Val Trp 
    1010                 1015                 1020             


Thr Glu  Lys Glu Gly Ala Ala  Lys Val Thr His Ser  Ala Ser Ile 
    1025                 1030                 1035             


Lys Glu  Asn Asp Val Val Ile  Lys Asn Tyr Gly Arg  Met Phe Arg 
    1040                 1045                 1050             


Leu Leu  His Asp Asp Arg Val  Lys Thr Leu Leu Pro  His Ile Tyr 
    1055                 1060                 1065             


Asp Ser  Ala Leu Ser Glu Asn  Ile Thr Gly Asp Arg  Ile Thr Val 
    1070                 1075                 1080             


Lys Asp  Asn Lys Val Ile Ile  Asp Lys Ser Leu Phe  Asp Glu Asp 
    1085                 1090                 1095             


Leu Met  Asn Tyr Asp Leu Arg  Arg His Glu Ile Cys  Glu Ile Ile 
    1100                 1105                 1110             


Leu Arg  Phe Glu Ala Ala Ser  Ile Lys Arg Phe Gly  Leu Asp Gly 
    1115                 1120                 1125             


Arg Val  Asp Phe Lys Ala Ala  Leu Asp Ala Leu Thr  Gly Arg Ser 
    1130                 1135                 1140             


Leu Leu  Asn Asp Glu Asp Ala  Arg Ile Leu Ser Ala  Ile Arg Asn 
    1145                 1150                 1155             


Ala Tyr  Asn His Asn Lys Tyr  Pro Ala Lys Gly Thr  Asp Val Lys 
    1160                 1165                 1170             


Val Asn  Val Met Ala Leu Pro  Lys Leu Thr Glu Asp  Leu Leu Arg 
    1175                 1180                 1185             


Ile Phe  Ser Asp Thr Gly Asn  Asn Arg Val Arg 
    1190                 1195                 


<210>  1364
<211>  1057
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1364

Met Thr Ile Lys Glu Gln Ser His Phe Ala Ala Tyr Tyr Asn Met Ala 
1               5                   10                  15      


Arg His Asn Met Tyr Glu Thr Leu Cys Tyr Ile Ser Lys Ile Ser Gly 
            20                  25                  30          


Ile Gln Glu Gly Glu Asp Asn Lys Glu Ser Lys Ile Glu Asp Met Gln 
        35                  40                  45              


Leu Leu Arg Val Leu Thr Thr Lys Gly His Pro Glu Glu Lys Ile Arg 
    50                  55                  60                  


Ile Glu Lys Leu Ile Tyr Lys His Leu Pro Leu Phe Arg Pro Ala Val 
65                  70                  75                  80  


Glu Asp Leu Arg Lys Lys Ser Lys Glu Asn Val Lys Ser Pro Glu Leu 
                85                  90                  95      


Leu Ala Lys Val Ile Lys Asn Trp Ala Lys Val Ile Thr Tyr Tyr Arg 
            100                 105                 110         


Asp Lys Phe Thr His Tyr Val Phe Ile Asp Lys Arg His Glu Asn Lys 
        115                 120                 125             


Glu Phe Leu Asn Ala Glu Met Ser Val Ala Asn Asp Leu Asn Gln Ile 
    130                 135                 140                 


Phe Thr Ala Ser Ala Arg Val Ile Lys Glu Arg Phe Gly Leu Ser Thr 
145                 150                 155                 160 


Glu Leu Glu Phe Leu Thr Lys Gly Arg Tyr Arg Thr Gln Thr Ile Asp 
                165                 170                 175     


Gly Lys Arg Ser Thr Lys Leu Asn Pro Asn Phe Ile Tyr Ser Leu Gln 
            180                 185                 190         


Asp Lys Asn Glu Arg Leu Asn Lys Met Gly Leu Ile Phe Leu Ala Cys 
        195                 200                 205             


Gln Leu Ile Glu Lys Lys Tyr Ala Ser Met Leu Phe Asp Gln Gln Gly 
    210                 215                 220                 


Tyr Met Gly Arg Asp Ile Tyr Phe Asp Phe Thr Pro Ala Gln Cys Lys 
225                 230                 235                 240 


Tyr Ile Arg Glu Val Phe Ser Ala His Arg Ile Val Leu Pro Arg Gly 
                245                 250                 255     


Arg Met Asp Val Glu Arg Asn Glu Ile Thr Ile Ala Met Asp Met Phe 
            260                 265                 270         


Asn Glu Leu Gly Lys Cys Pro Lys Glu Leu Phe Glu Ile Ile Ser Lys 
        275                 280                 285             


Glu Glu Gln Lys Arg Phe Arg Thr Lys Ser Glu Thr Thr Gly Glu Glu 
    290                 295                 300                 


Val Leu Leu Met Arg His Ser Asp Arg Phe Ala Thr Leu Ala Leu Gln 
305                 310                 315                 320 


Tyr Ile Asp Asn Arg Lys Val Phe Glu Lys Ile Arg Phe Gln Leu Ser 
                325                 330                 335     


Leu Gly Lys Tyr Arg Tyr Lys Phe Tyr Asp Lys Thr Cys Val Asp Gly 
            340                 345                 350         


Asp Thr His Val Arg Ile Leu Gln Lys Glu Leu Asn Gly Phe Gly Arg 
        355                 360                 365             


Ile Asn Glu Ile Glu Leu Leu Lys Glu Glu Lys Trp Gly Gly Leu Ile 
    370                 375                 380                 


Arg Lys Phe Glu Asp Ala Lys Ile Asp Thr Ala Glu Thr Lys Pro Tyr 
385                 390                 395                 400 


Ile Thr Asp Gln Tyr Pro Gln Tyr Leu Phe Asn Gly Asn Arg Ile Gly 
                405                 410                 415     


Ile Tyr Phe Asn Ser Ala His Gly Lys Ala Met Arg Asn Gly Ala Tyr 
            420                 425                 430         


Ile Pro Asp Ile Glu Ser Gly Ala His Cys Ile Gln Pro Ile Cys Trp 
        435                 440                 445             


Ile Ser Asn Tyr Glu Leu Pro Ala Leu Ile Phe His His Ile Leu Thr 
    450                 455                 460                 


Lys Asp Glu Lys Lys Ser Leu Thr Glu Lys Ile Ile Ile Asp Cys Val 
465                 470                 475                 480 


Glu Arg Tyr Lys Lys Leu Phe Asn Asp Ile Ala Glu Gly Lys Val Ala 
                485                 490                 495     


Arg Thr Gly Asn Ala Thr Ser Asp Phe Glu Met Ile Ser Lys Glu Tyr 
            500                 505                 510         


Gly Ile Glu Lys Ser Asp Ile Pro Arg Glu Leu Gln Asp Tyr Phe Asn 
        515                 520                 525             


Gly Thr Glu Arg Asp Gly Ile Glu Gln Tyr Ala Lys Ala Gln Ile Arg 
    530                 535                 540                 


Glu Met Ile Glu Glu Asn Arg Ile Arg Leu Glu Gln Phe Asn Ser Lys 
545                 550                 555                 560 


Leu Lys Lys Ile Glu Asp Gly Glu Val Lys Tyr Gly Lys Arg Asp Tyr 
                565                 570                 575     


Thr Glu Ile Arg Thr Gly Glu Leu Ala Gln Tyr Leu Ala Lys Asp Ile 
            580                 585                 590         


Val Met Phe Met Pro Lys Ala Lys Tyr Lys Pro Thr Ser Lys Asn Tyr 
        595                 600                 605             


Asn Val Met Gln Ala Leu Leu Ala Thr Phe Asn Gly Ser Glu Ser Gly 
    610                 615                 620                 


Ser Thr Leu Asp Glu Val Asp Asp Met Phe Asp Asn Ile Lys Ala Cys 
625                 630                 635                 640 


Tyr Trp Lys Asn Glu Ser Asp Asn His Pro Phe Leu Glu Tyr Val Leu 
                645                 650                 655     


Gly Glu Glu Pro Lys Asp Ile Ile Ala Phe Tyr Lys Ile Tyr Leu Glu 
            660                 665                 670         


Leu Arg Gly Glu Tyr Leu Asp Lys Cys Ile Lys Lys Met Asp Leu Ala 
        675                 680                 685             


Thr Ile Pro Phe Ile His Thr Glu Arg Lys Arg Trp Glu Lys Arg Asp 
    690                 695                 700                 


Glu Lys Phe Phe Lys Glu Leu Ala Gln Arg Tyr Ala Thr Gln Pro Ile 
705                 710                 715                 720 


Glu Leu Pro Arg Gly Leu Tyr Asp Arg Ala Ile Lys Glu Tyr Leu Lys 
                725                 730                 735     


Ser Lys Ser Ile Leu Glu Asp Val Ile Ala Gln Glu Gln Cys Asn Val 
            740                 745                 750         


Thr Tyr Leu Ile Ala Arg Tyr Met Gln Asp Val Leu Lys Asp Asp Ser 
        755                 760                 765             


Gln Gln Phe Tyr Ser Leu Pro Arg His Tyr Ser Cys Leu Ser Glu Lys 
    770                 775                 780                 


Asp Lys Tyr Leu Ser Leu Thr Glu Arg Glu Ala Ile Ala Lys Ser Asp 
785                 790                 795                 800 


Ala Leu Asn Ser Phe Lys Lys Arg Glu Arg Glu Lys Glu Asn Glu Asn 
                805                 810                 815     


Arg Arg Gly Asn Arg Arg Tyr Asn Lys Gly Glu Asn Lys Asn Thr Ile 
            820                 825                 830         


Lys Asp Arg Asp Thr Glu Glu Lys Phe Asn Ser Leu Tyr Arg Lys Met 
        835                 840                 845             


Asp Asn Asn Glu Arg Ile Leu Arg Arg Tyr Lys Val Gln Asp Met Leu 
    850                 855                 860                 


Leu Tyr Leu Leu Ala Cys Asp Ile Ile Lys Gly Ile Met Arg Glu Asp 
865                 870                 875                 880 


Phe Gly Tyr Lys Leu Ser Met Ile Thr Asp Gly Lys Asn Ser Asn Phe 
                885                 890                 895     


Phe Asp Tyr Lys Met Pro Glu Phe Lys Thr Thr Ile Thr Leu Lys Glu 
            900                 905                 910         


Gly Lys Lys Phe Thr Ile Lys Gln Gln Tyr Leu Lys Ile Lys Asn Tyr 
        915                 920                 925             


Gly Asp Phe Leu Lys Phe Ile Phe Asp Leu Arg Ile Asp Ser Leu Leu 
    930                 935                 940                 


Ser Asn Gly Thr Lys Val Glu Ile Asp Arg Asn Ile Leu Glu Asp Glu 
945                 950                 955                 960 


Leu Ser Asn Tyr Asp Gly Ser Arg Pro Lys Val Phe Glu Thr Leu Leu 
                965                 970                 975     


Met Ile Glu Lys Ile Val Val Glu Lys His Lys Glu Leu Lys Asp Leu 
            980                 985                 990         


Glu His Ile Thr Phe Gly Asp Val  Leu Asn Val Ile Lys  Met Glu Glu 
        995                 1000                 1005             


Gly Glu  Lys Lys Ile Leu Arg  Leu Ile Arg Asn Ala  Phe Ser His 
    1010                 1015                 1020             


Asn Tyr  Tyr Pro Thr Ile Lys  Asp Val Asn Tyr Asp  Asn Met Pro 
    1025                 1030                 1035             


Glu Val  Ala Glu Ser Leu Lys  Asp Ile Leu Glu Lys  Glu Ser Lys 
    1040                 1045                 1050             


Lys Leu  Thr Asn 
    1055         


<210>  1365
<211>  1165
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1365

Met Lys Asn Gln Asn Ser Leu Pro Ser Asn Pro Thr Asp Ile Leu Glu 
1               5                   10                  15      


Asp Lys Pro Phe Trp Ala Ala Phe Phe Asn Leu Ala Arg His Asn Val 
            20                  25                  30          


Tyr Leu Thr Val Asn His Ile Asn Lys Leu Leu Asp Leu Glu Lys Leu 
        35                  40                  45              


Tyr Asn Lys Asp Lys His Lys Glu Ile Phe Glu His Glu Asp Ile Phe 
    50                  55                  60                  


Asn Ile Ser Asp Asp Val Met Asn Asp Ala Asn Ser Asn Gly Lys Lys 
65                  70                  75                  80  


Arg Lys Leu Asp Ile Lys Lys Ile Trp Asp Asp Leu Asp Thr Asp Leu 
                85                  90                  95      


Thr Arg Lys Tyr Leu Leu Arg Glu Leu Ile Leu Lys His Phe Pro Phe 
            100                 105                 110         


Ile Gln Pro Ala Ile Ile Gly Thr Gln Thr Lys Glu Arg Thr Thr Ile 
        115                 120                 125             


Asp Lys Asp Lys Lys Arg Thr Ser Thr Ser Asn Asp Ser Leu Lys Gln 
    130                 135                 140                 


Thr Gly Glu Gly Asp Ile Asn Asp Pro Leu Ser Leu Ser Asn Val Lys 
145                 150                 155                 160 


Ser Met Phe Phe Arg Leu Leu Gln Met Leu Glu Gln Leu Arg Asn Tyr 
                165                 170                 175     


Tyr Ser His Val Lys His Ser Lys Ser Ala Thr Met Pro Asn Phe Asp 
            180                 185                 190         


Glu Gly Leu Leu Lys Ser Met Tyr Asn Ile Phe Ile Asp Ser Val Asn 
        195                 200                 205             


Lys Val Lys Glu Asp Tyr Ser Ser Asn Ser Val Ile Asp Pro Asn Thr 
    210                 215                 220                 


Ser Phe Ser His Leu Ile Tyr Lys Asp Lys Tyr Gly Glu Ile Lys Pro 
225                 230                 235                 240 


Cys Arg Tyr Pro Phe Thr Ser Lys Asp Gly Ser Ile Asn Ala Ser Gly 
                245                 250                 255     


Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys Gln Asp Ser Ile Trp 
            260                 265                 270         


Met Gln Lys Lys Ile Pro Gly Phe Lys Lys Ala Ser Glu Asn Tyr Met 
        275                 280                 285             


Lys Met Thr Asn Glu Val Phe Cys Arg Asn His Ile Leu Leu Pro Lys 
    290                 295                 300                 


Met Arg Leu Glu Ala Val Tyr Asp Lys Asp Trp Met Leu Leu Asp Met 
305                 310                 315                 320 


Leu Asn Glu Val Val Arg Cys Pro Leu Ser Leu Tyr Lys Arg Leu Thr 
                325                 330                 335     


Pro Ala Asp Gln Asn Lys Phe Lys Val Pro Glu Lys Ser Ser Asp Asn 
            340                 345                 350         


Ala Asn Gln Gln Glu Asp Asp Asn Pro Phe Ser Arg Ile Leu Val Arg 
        355                 360                 365             


His Gln Asn Arg Phe Pro Tyr Phe Val Leu Arg Phe Phe Asp Leu Asn 
    370                 375                 380                 


Glu Val Phe Thr Thr Leu Arg Phe Gln Ile Asn Leu Gly Cys Tyr His 
385                 390                 395                 400 


Phe Ala Ile Tyr Lys Lys Gln Ile Gly Asp Lys Lys Glu Val His His 
                405                 410                 415     


Leu Thr Arg Thr Leu Tyr Gly Phe Ser Arg Leu Gln Asn Phe Thr Gln 
            420                 425                 430         


Asn Thr Arg Pro Glu Glu Trp Asn Thr Leu Val Lys Thr Thr Glu Pro 
        435                 440                 445             


Ser Ser Gly Asn Asp Gly Lys Met Val Gln Gly Val Pro Leu Pro Tyr 
    450                 455                 460                 


Ile Ser Tyr Thr Ile Pro His Tyr Gln Ile Glu Asn Glu Lys Ile Gly 
465                 470                 475                 480 


Ile Lys Ile Phe Gly Glu Asp Thr Ala Val Asp Thr Asp Ile Trp Pro 
                485                 490                 495     


Ser Val Ser Thr Glu Lys Gln Leu Asn Lys Pro Asp Lys Tyr Thr Leu 
            500                 505                 510         


Thr Pro Gly Phe Lys Ala Asp Val Phe Leu Ser Val His Glu Leu Leu 
        515                 520                 525             


Pro Met Met Phe Tyr Tyr Gln Leu Leu Leu Cys Glu Gly Met Leu Lys 
    530                 535                 540                 


Thr Asp Ala Gly Asn Ala Val Glu Lys Val Leu Ile Asp Thr Arg Asn 
545                 550                 555                 560 


Ala Ile Phe Asn Leu Tyr Asp Ala Phe Val Gln Glu Lys Ile Asn Thr 
                565                 570                 575     


Ile Thr Asp Leu Glu Asn Tyr Leu Gln Asp Lys Pro Ile Leu Ile Gly 
            580                 585                 590         


His Leu Pro Lys Gln Met Ile Asp Leu Leu Lys Gly His Gln Arg Asp 
        595                 600                 605             


Met Leu Lys Ala Val Glu Gln Lys Lys Ala Met Leu Ile Lys Asp Thr 
    610                 615                 620                 


Glu Arg Arg Leu Glu Arg Leu Asn Lys Gln Pro Glu Gln Lys Pro Asn 
625                 630                 635                 640 


Val Ala Ala Lys Asn Thr Gly Thr Leu Leu Arg Asn Gly Gln Ile Ala 
                645                 650                 655     


Asp Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Lys Arg Asp 
            660                 665                 670         


Lys Glu Gly Asn Pro Ile Asn Cys Ser Lys Ala Asn Ser Thr Glu Tyr 
        675                 680                 685             


Gln Met Leu Gln Arg Ala Phe Ala Phe Tyr Thr Thr Asp Ser Tyr Arg 
    690                 695                 700                 


Leu Pro Arg Tyr Phe Glu Gln Leu His Leu Ile Asn Cys Asp Asn Ser 
705                 710                 715                 720 


His Leu Phe Leu Ser Arg Phe Glu Tyr Asp Lys Gln Pro Asn Leu Ile 
                725                 730                 735     


Ala Phe Tyr Ala Ala Tyr Leu Glu Ala Lys Leu Glu Phe Leu Asn Glu 
            740                 745                 750         


Leu Gln Pro Gln Asn Trp Ala Ser Asp Asn Tyr Phe Leu Leu Leu Arg 
        755                 760                 765             


Ala Pro Lys Asn Asp Arg Gln Lys Leu Ala Glu Gly Trp Lys Asn Gly 
    770                 775                 780                 


Phe Asn Leu Pro Arg Gly Leu Phe Thr Glu Lys Ile Lys Thr Trp Phe 
785                 790                 795                 800 


Asn Glu His Lys Thr Ile Val Asp Ile Ser Asp Cys Asp Ile Phe Lys 
                805                 810                 815     


Asn Arg Val Gly Gln Val Ala Arg Leu Ile Pro Val Phe Phe Asp Lys 
            820                 825                 830         


Lys Phe Lys Asp His Ser Gln Pro Phe Tyr Arg Tyr Asn Phe Asn Val 
        835                 840                 845             


Gly Asn Val Ser Lys Pro Thr Glu Ala Asn Tyr Leu Ser Lys Gly Lys 
    850                 855                 860                 


Arg Glu Glu Leu Phe Lys Ser Tyr Gln Asn Lys Phe Lys Asn Asn Ile 
865                 870                 875                 880 


Pro Ala Glu Lys Thr Lys Glu Tyr Arg Glu Tyr Lys Asn Phe Ser Ser 
                885                 890                 895     


Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys Asn Gln Asp Ile 
            900                 905                 910         


Leu Thr Trp Leu Met Cys Lys Asn Leu Phe Asp Glu Lys Ile Lys Pro 
        915                 920                 925             


Gln Lys Asp Ile Leu Glu Pro Arg Ile Ala Val Ser Tyr Ile Lys Leu 
    930                 935                 940                 


Asp Ser Leu Gln Thr Asn Thr Ser Thr Ala Gly Ser Leu Asn Ala Leu 
945                 950                 955                 960 


Ala Lys Val Val Pro Met Thr Leu Ala Ile His Ile Asp Ser Pro Lys 
                965                 970                 975     


Pro Lys Gly Lys Ala Arg Asn Asn Glu Lys Glu Asn Lys Glu Phe Thr 
            980                 985                 990         


Val Tyr Ile Lys Glu Glu Gly Thr  Lys Leu Leu Lys Trp  Gly Asn Phe 
        995                 1000                 1005             


Lys Thr  Leu Leu Ala Asp Arg  Arg Ile Lys Gly Leu  Phe Ser Tyr 
    1010                 1015                 1020             


Ile Glu  His Asp Asp Ile Asn  Leu Glu Lys Tyr Pro  Leu Thr Lys 
    1025                 1030                 1035             


Tyr Gln  Val Asp Ser Glu Leu  Asp Leu Tyr Gln Lys  Tyr Arg Ile 
    1040                 1045                 1050             


Asp Ile  Phe Lys Gln Thr Leu  Asp Leu Glu Ala Gln  Leu Leu Asp 
    1055                 1060                 1065             


Lys Tyr  Ser Asp Leu Asn Thr  Asp Asn Phe Tyr Gln  Met Leu Ile 
    1070                 1075                 1080             


Gly Trp  Arg Lys Lys Glu Gly  Ile Pro Arg Asp Ile  Lys Glu Asp 
    1085                 1090                 1095             


Thr Asp  Phe Leu Lys Asp Val  Arg Asn Ala Phe Ser  His Asn Gln 
    1100                 1105                 1110             


Tyr Pro  Asp Ser Lys Lys Ile  Ala Phe Ser Arg Ile  Arg Lys Phe 
    1115                 1120                 1125             


Asn Pro  Lys Glu Leu Ile Leu  Glu Glu Lys Lys Gly  Leu Ser Ile 
    1130                 1135                 1140             


Ala Lys  Gln Met Tyr Glu Glu  Val Glu Lys Val Val  Asn Arg Ile 
    1145                 1150                 1155             


Lys Glu  Ile Glu Leu Phe Asp  
    1160                 1165 


<210>  1366
<211>  1165
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1366

Met Lys Asn Gln Asn Ser Leu Pro Ser Asn Pro Thr Asp Ile Leu Glu 
1               5                   10                  15      


Asp Lys Pro Phe Trp Ala Ala Phe Phe Asn Leu Ala Arg His Asn Val 
            20                  25                  30          


Tyr Leu Thr Val Asn His Ile Asn Lys Leu Leu Asp Leu Glu Lys Leu 
        35                  40                  45              


Tyr Asn Lys Asp Lys His Lys Glu Ile Phe Glu His Glu Asp Ile Phe 
    50                  55                  60                  


Asn Ile Ser Asp Asp Val Met Asn Asp Ala Asn Ser Asn Gly Lys Lys 
65                  70                  75                  80  


Arg Lys Leu Asp Ile Lys Lys Ile Trp Asp Asp Leu Asp Thr Asp Leu 
                85                  90                  95      


Thr Arg Lys Tyr Leu Leu Arg Glu Leu Ile Leu Lys His Phe Pro Phe 
            100                 105                 110         


Ile Gln Pro Ala Ile Ile Gly Thr Gln Thr Lys Glu Arg Thr Thr Ile 
        115                 120                 125             


Asp Lys Asp Lys Lys Arg Thr Ser Thr Ser Asn Asp Ser Leu Lys Gln 
    130                 135                 140                 


Thr Gly Glu Gly Asp Ile Asn Asp Pro Leu Ser Leu Ser Asn Val Lys 
145                 150                 155                 160 


Ser Met Phe Phe Arg Leu Leu Gln Met Leu Glu Gln Leu Arg Asn Tyr 
                165                 170                 175     


Tyr Ser His Val Lys His Ser Lys Ser Ala Thr Met Pro Asn Phe Asp 
            180                 185                 190         


Glu Gly Leu Leu Lys Ser Met Tyr Asn Ile Phe Ile Asp Ser Val Asn 
        195                 200                 205             


Lys Val Lys Glu Asp Tyr Ser Ser Asn Ser Val Ile Asp Pro Asn Thr 
    210                 215                 220                 


Ser Phe Ser His Leu Ile Tyr Lys Asp Lys Tyr Gly Glu Ile Lys Pro 
225                 230                 235                 240 


Cys Arg Tyr Pro Phe Thr Ser Lys Asp Gly Ser Ile Asn Ala Ser Gly 
                245                 250                 255     


Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys Gln Asp Ser Ile Trp 
            260                 265                 270         


Met Gln Lys Lys Ile Pro Gly Phe Lys Lys Ala Ser Glu Asn Tyr Met 
        275                 280                 285             


Lys Met Thr Asn Glu Val Phe Cys Arg Asn His Ile Leu Leu Pro Lys 
    290                 295                 300                 


Met Arg Leu Glu Ala Val Tyr Asp Lys Asp Trp Met Leu Leu Asp Met 
305                 310                 315                 320 


Leu Asn Glu Val Val Arg Cys Pro Leu Ser Leu Tyr Lys Arg Leu Thr 
                325                 330                 335     


Pro Ala Asp Gln Asn Lys Phe Lys Val Pro Glu Lys Ser Ser Asp Asn 
            340                 345                 350         


Ala Asn Gln Gln Glu Asp Asp Asn Pro Phe Ser Arg Ile Leu Val Arg 
        355                 360                 365             


His Gln Asn Arg Phe Pro Tyr Phe Val Leu Arg Phe Phe Asp Leu Asn 
    370                 375                 380                 


Glu Val Phe Thr Thr Leu Arg Phe Gln Ile Asn Leu Gly Cys Tyr His 
385                 390                 395                 400 


Phe Ala Ile Tyr Lys Lys Gln Ile Gly Asp Lys Lys Glu Val His His 
                405                 410                 415     


Leu Thr Arg Thr Leu Tyr Gly Phe Ser Arg Leu Gln Asn Phe Thr Gln 
            420                 425                 430         


Asn Thr Arg Pro Glu Glu Trp Asn Thr Leu Val Lys Thr Thr Glu Pro 
        435                 440                 445             


Ser Ser Gly Asn Asp Gly Lys Met Val Gln Gly Val Pro Leu Pro Tyr 
    450                 455                 460                 


Ile Ser Tyr Thr Ile Pro His Tyr Gln Ile Glu Asn Glu Lys Ile Gly 
465                 470                 475                 480 


Ile Lys Ile Phe Gly Glu Asp Thr Ala Val Asp Thr Asp Ile Trp Pro 
                485                 490                 495     


Ser Val Ser Thr Glu Lys Gln Leu Asn Lys Pro Asp Lys Tyr Thr Leu 
            500                 505                 510         


Thr Pro Gly Phe Lys Ala Asp Val Phe Leu Ser Val His Glu Leu Leu 
        515                 520                 525             


Pro Met Met Phe Tyr Tyr Gln Leu Leu Leu Cys Glu Gly Met Leu Lys 
    530                 535                 540                 


Thr Asp Ala Gly Asn Ala Val Glu Lys Val Leu Ile Asp Thr Arg Asn 
545                 550                 555                 560 


Ala Ile Phe Asn Leu Tyr Asp Ala Phe Val Gln Glu Lys Ile Asn Thr 
                565                 570                 575     


Ile Thr Asp Leu Glu Asn Tyr Leu Gln Asp Lys Pro Ile Leu Ile Gly 
            580                 585                 590         


His Leu Pro Lys Gln Met Ile Asp Leu Leu Lys Gly His Gln Arg Asp 
        595                 600                 605             


Met Leu Lys Ala Val Glu Gln Lys Lys Ala Met Leu Ile Lys Asp Thr 
    610                 615                 620                 


Glu Arg Arg Leu Glu Arg Leu Asn Lys Gln Pro Glu Gln Lys Pro Asn 
625                 630                 635                 640 


Val Ala Ala Lys Asn Thr Gly Thr Leu Leu Arg Asn Gly Gln Ile Ala 
                645                 650                 655     


Asp Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Lys Arg Asp 
            660                 665                 670         


Lys Glu Gly Asn Pro Ile Asn Cys Ser Lys Ala Asn Ser Thr Glu Tyr 
        675                 680                 685             


Gln Met Leu Gln Arg Ala Phe Ala Phe Tyr Thr Thr Asp Ser Tyr Arg 
    690                 695                 700                 


Leu Pro Arg Tyr Phe Glu Gln Leu His Leu Ile Asn Cys Asp Asn Ser 
705                 710                 715                 720 


His Leu Phe Leu Ser Arg Phe Glu Tyr Asp Lys Gln Pro Asn Leu Ile 
                725                 730                 735     


Ala Phe Tyr Ala Ala Tyr Leu Glu Ala Lys Leu Glu Phe Leu Asn Glu 
            740                 745                 750         


Leu Gln Pro Gln Asn Trp Ala Ser Asp Asn Tyr Phe Leu Leu Leu Arg 
        755                 760                 765             


Ala Pro Lys Asn Asp Arg Gln Lys Leu Ala Glu Gly Trp Lys Asn Gly 
    770                 775                 780                 


Phe Asn Leu Pro Arg Gly Leu Phe Thr Glu Lys Ile Lys Thr Trp Phe 
785                 790                 795                 800 


Asn Glu His Lys Thr Ile Val Asp Ile Ser Asp Cys Asp Ile Phe Lys 
                805                 810                 815     


Asn Arg Val Gly Gln Val Ala Arg Leu Ile Pro Val Phe Phe Asp Lys 
            820                 825                 830         


Lys Phe Lys Asp His Ser Gln Pro Phe Tyr Arg Tyr Asn Phe Asn Val 
        835                 840                 845             


Gly Asn Val Ser Lys Pro Thr Glu Ala Asn Tyr Leu Ser Lys Gly Lys 
    850                 855                 860                 


Arg Glu Glu Leu Phe Lys Ser Tyr Gln Asn Lys Phe Lys Asn Asn Ile 
865                 870                 875                 880 


Pro Ala Glu Lys Thr Lys Glu Tyr Arg Glu Tyr Lys Asn Phe Ser Ser 
                885                 890                 895     


Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys Asn Gln Asp Ile 
            900                 905                 910         


Leu Thr Trp Leu Met Cys Lys Asn Leu Phe Asp Glu Lys Ile Lys Pro 
        915                 920                 925             


Gln Lys Asp Ile Leu Glu Pro Arg Ile Ala Val Ser Tyr Ile Lys Leu 
    930                 935                 940                 


Asp Ser Leu Gln Thr Asn Thr Ser Thr Ala Gly Ser Leu Asn Ala Leu 
945                 950                 955                 960 


Ala Lys Val Val Pro Met Thr Leu Ala Ile His Ile Asp Ser Pro Lys 
                965                 970                 975     


Pro Lys Gly Lys Ala Arg Asn Asn Glu Lys Glu Asn Lys Glu Phe Thr 
            980                 985                 990         


Val Tyr Ile Lys Glu Glu Gly Thr  Lys Leu Leu Lys Trp  Gly Asn Phe 
        995                 1000                 1005             


Lys Thr  Leu Leu Ala Asp Arg  Arg Ile Lys Gly Leu  Phe Ser Tyr 
    1010                 1015                 1020             


Ile Glu  His Asp Asp Ile Asn  Leu Glu Lys Tyr Pro  Leu Thr Lys 
    1025                 1030                 1035             


Tyr Gln  Val Asp Ser Glu Leu  Asp Leu Tyr Gln Lys  Tyr Arg Ile 
    1040                 1045                 1050             


Asp Ile  Phe Lys Gln Thr Leu  Asp Leu Glu Ala Gln  Leu Leu Asp 
    1055                 1060                 1065             


Lys Tyr  Ser Asp Leu Asn Thr  Asp Asn Phe Tyr Gln  Met Leu Ile 
    1070                 1075                 1080             


Gly Trp  Arg Lys Lys Glu Gly  Ile Pro Arg Asp Ile  Lys Glu Asp 
    1085                 1090                 1095             


Thr Asp  Phe Leu Lys Asp Val  Arg Asn Ala Phe Ser  His Asn Gln 
    1100                 1105                 1110             


Tyr Pro  Asp Ser Lys Lys Ile  Ala Phe Ser Arg Ile  Arg Lys Phe 
    1115                 1120                 1125             


Asn Pro  Lys Glu Leu Ile Leu  Glu Glu Lys Lys Gly  Leu Ser Ile 
    1130                 1135                 1140             


Ala Lys  Gln Met Tyr Glu Glu  Val Glu Lys Val Val  Asn Arg Ile 
    1145                 1150                 1155             


Lys Glu  Ile Glu Leu Phe Asp  
    1160                 1165 


<210>  1367
<211>  1119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1367

Met Lys Glu Glu Glu Ile Pro Val Val Ser Thr Tyr Asn Lys Asp Asp 
1               5                   10                  15      


Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val Tyr 
            20                  25                  30          


Ile Thr Ile Asn His Ile Asn Lys Leu Leu Glu Ile Arg Glu Ile Asp 
        35                  40                  45              


Asn Asp Glu Lys Val Leu Asp Ile Lys Ala Leu Trp Gln Lys Val Asn 
    50                  55                  60                  


Lys Asp Leu Asn Gln Lys Ala Arg Leu Arg Glu Leu Met Thr Lys His 
65                  70                  75                  80  


Phe Pro Phe Leu Glu Thr Ala Ile Tyr Ser Lys Asn Lys Glu Asp Lys 
                85                  90                  95      


Glu Glu Val Lys Gln Glu Lys Gln Ala Thr Ala Gln Ser Phe Lys Ser 
            100                 105                 110         


Leu Glu His Cys Leu Phe Leu Phe Leu Glu Lys Leu Gln Glu Ala Arg 
        115                 120                 125             


Asn Tyr Tyr Ser His Tyr Lys Tyr Ser Glu Ser Thr Lys Glu Pro Val 
    130                 135                 140                 


Leu Glu Lys Glu Leu Leu Lys Lys Met Tyr Asn Ile Phe Asp Asn Asn 
145                 150                 155                 160 


Ile Gln Leu Val Ile Lys Asp Tyr Gln His Asn Lys Asp Ile Asn Pro 
                165                 170                 175     


Asp Glu Asp Phe Lys His Leu Asp Arg Thr Glu Lys Glu Phe Asn Tyr 
            180                 185                 190         


Tyr Phe Thr Gln Asp Lys Lys Gly Lys Ile Thr Glu Ser Gly Leu Leu 
        195                 200                 205             


Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Met Gln 
    210                 215                 220                 


Gln Lys Leu Thr Gly Phe Lys Asp Asn Arg Glu Asn Asn Lys Gln Met 
225                 230                 235                 240 


Thr His Glu Val Phe Cys Arg Ser Arg Ile Leu Met Pro Lys Leu Arg 
                245                 250                 255     


Leu Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu Asn 
            260                 265                 270         


Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Lys Gly Glu 
        275                 280                 285             


Asp Arg Lys Lys Phe Glu Val Pro Phe Asp Ser Thr Asp Glu Asp Tyr 
    290                 295                 300                 


Asp Ala Glu Gln Asp Pro Phe Lys Asn Thr Leu Ile Arg His Gln Asp 
305                 310                 315                 320 


Arg Phe Pro Tyr Phe Ile Leu Arg Tyr Phe Asp Tyr Asn Glu Ile Phe 
                325                 330                 335     


Lys Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile 
            340                 345                 350         


Tyr Lys Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg His Leu Thr His 
        355                 360                 365             


Lys Leu Tyr Gly Phe Glu Arg Ile Gln Glu Phe Thr Lys Gln His Arg 
    370                 375                 380                 


Pro Asp Asp Trp Lys Ala Ile Val Lys Asp Phe Asp Thr Tyr Glu Thr 
385                 390                 395                 400 


Ser Glu Glu Pro Tyr Ile Ser Glu Thr Thr Pro His Tyr His Leu Glu 
                405                 410                 415     


Asn Gln Lys Ile Gly Ile Arg Phe Lys Asn Asp Asn Asp Lys Ile Trp 
            420                 425                 430         


Pro Ser Leu Glu Thr Asn Gly Glu Asn Asn Glu Lys Ser Lys Tyr Lys 
        435                 440                 445             


Leu Asp Lys Gln Tyr Gln Ala Glu Ala Phe Leu Ser Val His Glu Leu 
    450                 455                 460                 


Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Lys Lys Glu Glu Pro Asn 
465                 470                 475                 480 


Asn Asp Lys Lys Asn Ala Ser Arg Val Glu Gly Phe Ile Lys Arg Glu 
                485                 490                 495     


Ile Arg Asp Ile Phe Lys Leu Tyr Asp Ala Phe Ala Asn Asp Glu Ile 
            500                 505                 510         


Asn Asn Ile Asp Asp Leu Lys Lys Tyr Tyr Lys Asp Lys Asn Val Glu 
        515                 520                 525             


Ile Arg His Leu Pro Lys Gln Met Ile Ala Ile Leu Glu Ser Lys Pro 
    530                 535                 540                 


Lys Asp Met Ala Lys Glu Ala Lys Arg Lys Gln Lys Glu Met Val Lys 
545                 550                 555                 560 


Asp Thr Lys Lys Leu Leu Ala Thr Leu Glu Lys Gln Thr Gln Lys Glu 
                565                 570                 575     


Lys Glu Asp Asp Gly Arg Asn Val Lys Leu Leu Lys Ser Gly Glu Ile 
            580                 585                 590         


Ala Arg Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln Lys 
        595                 600                 605             


Asp Asn Glu Gly Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu 
    610                 615                 620                 


Tyr Gln Met Leu Gln Arg Ser Leu Ala Leu Tyr Asn Lys Glu Glu Lys 
625                 630                 635                 640 


Pro Thr Arg Tyr Phe Arg Gln Val Asn Leu Ile Glu Ser Ser Asn Pro 
                645                 650                 655     


His Pro Phe Leu Lys Trp Thr Lys Trp Glu Glu Cys Asn Asn Ile Leu 
            660                 665                 670         


Thr Phe Tyr His Arg Tyr Leu Thr Lys Lys Ile Glu Phe Leu Asn Lys 
        675                 680                 685             


Leu Lys Pro Glu Asp Trp Lys Lys Asn Gln Tyr Phe Leu Lys Val Lys 
    690                 695                 700                 


Glu Pro Lys Thr Asn Arg Glu Thr Leu Val Gln Gly Trp Lys Asn Gly 
705                 710                 715                 720 


Phe Asn Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg Glu Trp Phe 
                725                 730                 735     


Glu Arg His Gln Asn Asp Ser Glu Glu Tyr Lys Lys Val Glu Lys Leu 
            740                 745                 750         


Asn Lys Ala Gly Leu Val Thr Lys Val Ile Pro Leu Phe Phe Lys Glu 
        755                 760                 765             


Glu Pro Phe Lys Glu Asp Thr Lys Lys Glu Ile Asn Asp Trp Val Gln 
    770                 775                 780                 


Pro Phe Tyr Ser Phe Pro Tyr Asn Val Gly Asn Ile His Lys Pro Lys 
785                 790                 795                 800 


Glu Glu Asp Phe Leu His Arg Glu Glu Arg Ile Glu Leu Trp Asp Lys 
                805                 810                 815     


Lys Lys Asp Lys Phe Lys Gly Tyr Lys Glu Lys Ile Lys Ser Lys Lys 
            820                 825                 830         


Leu Thr Glu Lys Glu Lys Glu Glu Phe Arg Ser Tyr Leu Glu Phe Gln 
        835                 840                 845             


Ser Trp Asn Lys Phe Glu Arg Glu Leu Arg Leu Val Arg Asn Gln Asp 
    850                 855                 860                 


Ile Val Thr Trp Leu Leu Cys Lys Glu Leu Ile Asp Lys Leu Lys Ile 
865                 870                 875                 880 


Asp Glu Leu Asn Ile Glu Glu Leu Lys Lys Leu Arg Leu Asn Asn Ile 
                885                 890                 895     


Asp Thr Asp Thr Ala Lys Lys Glu Lys Asn Asn Ile Leu Asn Arg Val 
            900                 905                 910         


Met Pro Met Glu Leu Pro Val Thr Val Tyr Glu Val Asn Lys Ala Gly 
        915                 920                 925             


Asn Ile Ile Lys Asp Lys Pro Leu His Thr Ile Tyr Ile Lys Glu Ser 
    930                 935                 940                 


Lys Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys Asp 
945                 950                 955                 960 


Arg Arg Leu Asn Gly Leu Phe Ser Phe Val Lys Thr Asn Ser Glu Ala 
                965                 970                 975     


Glu Ser Lys Arg Asn Pro Ile Ser Lys Leu Arg Val Glu His Glu Leu 
            980                 985                 990         


Arg Glu Tyr Gln Lys Ala Arg Ile  Glu Ile Ile Lys Asp  Met Leu Ala 
        995                 1000                 1005             


Leu Glu  Lys Thr Leu Ile Asp  Asn Tyr Asn Ser Leu  Asp Thr Asp 
    1010                 1015                 1020             


Asn Phe  His Asn Met Leu Thr  Gly Trp Leu Glu Leu  Lys Gly Glu 
    1025                 1030                 1035             


Val Asn  Lys Ala Lys Phe Asn  Asn Asp Val Arg Leu  Leu Thr Ala 
    1040                 1045                 1050             


Val Arg  Asn Ala Phe Ser His  Asn Gln Tyr Pro Met  Tyr Asp Glu 
    1055                 1060                 1065             


Asn Leu  Phe Val Asn Ile Glu  Arg Phe Ser Leu Ser  Ser Ser Lys 
    1070                 1075                 1080             


Ile Leu  Glu Ser Lys Gly Leu  Ser Ile Ala Val Lys  Leu Lys Glu 
    1085                 1090                 1095             


Glu Val  Ser Lys Ile Val Lys  Lys Ile Gln Glu Glu  Glu Asp Gly 
    1100                 1105                 1110             


Lys Lys  Glu Lys Glu Thr 
    1115                 


<210>  1368
<211>  1119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1368

Met Lys Glu Glu Glu Ile Pro Val Val Ser Thr Tyr Asn Lys Asp Asp 
1               5                   10                  15      


Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val Tyr 
            20                  25                  30          


Ile Thr Ile Asn His Ile Asn Lys Leu Leu Glu Ile Arg Glu Ile Asp 
        35                  40                  45              


Asn Asp Glu Lys Val Leu Asp Ile Lys Ala Leu Trp Gln Lys Val Asn 
    50                  55                  60                  


Lys Asp Leu Asn Gln Lys Ala Arg Leu Arg Glu Leu Met Thr Lys His 
65                  70                  75                  80  


Phe Pro Phe Leu Glu Thr Ala Ile Tyr Ser Lys Asn Lys Glu Asp Lys 
                85                  90                  95      


Glu Glu Val Lys Gln Glu Lys Gln Ala Thr Ala Gln Ser Phe Lys Ser 
            100                 105                 110         


Leu Glu His Cys Leu Phe Leu Phe Leu Glu Lys Leu Gln Glu Ala Arg 
        115                 120                 125             


Asn Tyr Tyr Ser His Tyr Lys Tyr Ser Glu Ser Thr Lys Glu Pro Val 
    130                 135                 140                 


Leu Glu Lys Glu Leu Leu Lys Lys Met Tyr Asn Ile Phe Asp Asn Asn 
145                 150                 155                 160 


Ile Gln Leu Val Ile Lys Asp Tyr Gln His Asn Lys Asp Ile Asn Pro 
                165                 170                 175     


Asp Glu Asp Phe Lys His Leu Asp Arg Thr Glu Lys Glu Phe Asn Tyr 
            180                 185                 190         


Tyr Phe Thr Gln Asp Lys Lys Gly Lys Ile Thr Glu Ser Gly Leu Leu 
        195                 200                 205             


Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Met Gln 
    210                 215                 220                 


Gln Lys Leu Thr Gly Phe Lys Asp Asn Arg Glu Asn Asn Lys Gln Met 
225                 230                 235                 240 


Thr His Glu Val Phe Cys Arg Ser Arg Ile Leu Met Pro Lys Leu Arg 
                245                 250                 255     


Leu Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu Asn 
            260                 265                 270         


Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Lys Gly Glu 
        275                 280                 285             


Asp Arg Lys Lys Phe Glu Val Pro Phe Asp Ser Thr Asp Glu Asp Tyr 
    290                 295                 300                 


Asp Ala Glu Gln Asp Pro Phe Lys Asn Thr Leu Ile Arg His Gln Asp 
305                 310                 315                 320 


Arg Phe Pro Tyr Phe Ile Leu Arg Tyr Phe Asp Tyr Asn Glu Ile Phe 
                325                 330                 335     


Lys Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile 
            340                 345                 350         


Tyr Lys Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg His Leu Thr His 
        355                 360                 365             


Lys Leu Tyr Gly Phe Glu Arg Ile Gln Glu Phe Thr Lys Gln His Arg 
    370                 375                 380                 


Pro Asp Asp Trp Lys Ala Ile Val Lys Asp Phe Asp Thr Tyr Glu Thr 
385                 390                 395                 400 


Ser Glu Glu Pro Tyr Ile Ser Glu Thr Thr Pro His Tyr His Leu Glu 
                405                 410                 415     


Asn Gln Lys Ile Gly Ile Arg Phe Lys Asn Asp Asn Asp Lys Ile Trp 
            420                 425                 430         


Pro Ser Leu Glu Thr Asn Gly Glu Asn Asn Glu Lys Ser Lys Tyr Lys 
        435                 440                 445             


Leu Asp Lys Gln Tyr Gln Ala Glu Ala Phe Leu Ser Val His Glu Leu 
    450                 455                 460                 


Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Lys Lys Glu Glu Pro Asn 
465                 470                 475                 480 


Asn Asp Lys Lys Asn Ala Ser Arg Val Glu Gly Phe Ile Lys Arg Glu 
                485                 490                 495     


Ile Arg Asp Ile Phe Lys Leu Tyr Asp Ala Phe Ala Asn Asp Glu Ile 
            500                 505                 510         


Asn Asn Ile Asp Asp Leu Lys Lys Tyr Tyr Lys Asp Lys Asn Val Glu 
        515                 520                 525             


Ile Arg His Leu Pro Lys Gln Met Ile Ala Ile Leu Glu Ser Lys Pro 
    530                 535                 540                 


Lys Asp Met Ala Lys Glu Ala Lys Arg Lys Gln Lys Glu Met Val Lys 
545                 550                 555                 560 


Asp Thr Lys Lys Leu Leu Ala Thr Leu Glu Lys Gln Thr Gln Lys Glu 
                565                 570                 575     


Lys Glu Asp Asp Gly Arg Asn Val Lys Leu Leu Lys Ser Gly Glu Ile 
            580                 585                 590         


Ala Arg Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln Lys 
        595                 600                 605             


Asp Asn Glu Gly Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu 
    610                 615                 620                 


Tyr Gln Met Leu Gln Arg Ser Leu Ala Leu Tyr Asn Lys Glu Glu Lys 
625                 630                 635                 640 


Pro Thr Arg Tyr Phe Arg Gln Val Asn Leu Ile Glu Ser Ser Asn Pro 
                645                 650                 655     


His Pro Phe Leu Lys Trp Thr Lys Trp Glu Glu Cys Asn Asn Ile Leu 
            660                 665                 670         


Thr Phe Tyr His Arg Tyr Leu Thr Lys Lys Ile Glu Phe Leu Asn Lys 
        675                 680                 685             


Leu Lys Pro Glu Asp Trp Lys Lys Asn Gln Tyr Phe Leu Lys Val Lys 
    690                 695                 700                 


Glu Pro Lys Thr Asn Arg Glu Thr Leu Val Gln Gly Trp Lys Asn Gly 
705                 710                 715                 720 


Phe Asn Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg Glu Trp Phe 
                725                 730                 735     


Glu Arg His Gln Asn Asp Ser Glu Glu Tyr Lys Lys Val Glu Lys Leu 
            740                 745                 750         


Asn Lys Ala Gly Leu Val Thr Lys Val Ile Pro Leu Phe Phe Lys Glu 
        755                 760                 765             


Glu Pro Phe Lys Glu Asp Thr Lys Lys Glu Ile Asn Asp Trp Val Gln 
    770                 775                 780                 


Pro Phe Tyr Ser Phe Pro Tyr Asn Val Gly Asn Ile His Lys Pro Lys 
785                 790                 795                 800 


Glu Glu Asp Phe Leu His Arg Glu Glu Arg Ile Glu Leu Trp Asp Lys 
                805                 810                 815     


Lys Lys Asp Lys Phe Lys Gly Tyr Lys Glu Lys Ile Lys Ser Lys Lys 
            820                 825                 830         


Leu Thr Glu Lys Glu Lys Glu Glu Phe Arg Ser Tyr Leu Glu Phe Gln 
        835                 840                 845             


Ser Trp Asn Lys Phe Glu Arg Glu Leu Arg Leu Val Arg Asn Gln Asp 
    850                 855                 860                 


Ile Val Thr Trp Leu Leu Cys Lys Glu Leu Ile Asp Lys Leu Lys Ile 
865                 870                 875                 880 


Asp Glu Leu Asn Ile Glu Glu Leu Lys Lys Leu Arg Leu Asn Asn Ile 
                885                 890                 895     


Asp Thr Asp Thr Ala Lys Lys Glu Lys Asn Asn Ile Leu Asn Arg Val 
            900                 905                 910         


Met Pro Met Glu Leu Pro Val Thr Val Tyr Glu Val Asn Lys Ala Gly 
        915                 920                 925             


Asn Ile Ile Lys Asp Lys Pro Leu His Thr Ile Tyr Ile Lys Glu Ser 
    930                 935                 940                 


Lys Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys Asp 
945                 950                 955                 960 


Arg Arg Leu Asn Gly Leu Phe Ser Phe Val Lys Thr Asn Ser Glu Ala 
                965                 970                 975     


Glu Ser Lys Arg Asn Pro Ile Ser Lys Leu Arg Val Glu His Glu Leu 
            980                 985                 990         


Arg Glu Tyr Gln Lys Ala Arg Ile  Glu Ile Ile Lys Asp  Met Leu Ala 
        995                 1000                 1005             


Leu Glu  Lys Thr Leu Ile Asp  Asn Tyr Asn Ser Leu  Asp Thr Asp 
    1010                 1015                 1020             


Asn Phe  His Asn Met Leu Thr  Gly Trp Leu Glu Leu  Lys Gly Glu 
    1025                 1030                 1035             


Val Asn  Lys Ala Lys Phe Asn  Asn Asp Val Arg Leu  Leu Thr Ala 
    1040                 1045                 1050             


Val Arg  Asn Ala Phe Ser His  Asn Gln Tyr Pro Met  Tyr Asp Glu 
    1055                 1060                 1065             


Asn Leu  Phe Val Asn Ile Glu  Arg Phe Ser Leu Ser  Ser Ser Lys 
    1070                 1075                 1080             


Ile Leu  Glu Ser Lys Gly Leu  Ser Ile Ala Val Lys  Leu Lys Glu 
    1085                 1090                 1095             


Glu Val  Ser Lys Ile Val Lys  Lys Ile Gln Glu Glu  Glu Asp Gly 
    1100                 1105                 1110             


Lys Lys  Glu Lys Glu Thr 
    1115                 


<210>  1369
<211>  1253
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1369

Met Leu Glu Ile Gln Ile Glu Lys Glu Lys Arg Gly Trp Phe Trp Ala 
1               5                   10                  15      


Met Asn Leu Thr Met Ala Leu Asn Asn Leu Glu Thr Ile Ala Lys Arg 
            20                  25                  30          


Ala Leu Asn Val Leu Gly Lys Pro Tyr Pro Ala Ser Gln Ser Glu Asp 
        35                  40                  45              


Glu Gln Thr Asn Ala Leu Lys Gln Ala Leu Asp Glu Leu Gln Lys Gln 
    50                  55                  60                  


Pro Leu Ile Cys Gln Thr Lys Ile Glu Arg Val Phe Phe Arg Ser Leu 
65                  70                  75                  80  


Pro His Leu Asn Lys Phe Arg Gln Phe Ile Glu Met Gly Gly Glu Lys 
                85                  90                  95      


Ser Ser Ala Ser Tyr Val Glu Lys Ser Ser Ser Arg Ala Asp Ala Glu 
            100                 105                 110         


Ala Thr Gln Arg Gln Ser Gly Arg Asp Phe Thr Ser Asp Asp Leu Phe 
        115                 120                 125             


Gln Leu Ala Arg Tyr Tyr Leu Lys Ser Leu Val Glu Leu Arg Asn Tyr 
    130                 135                 140                 


Phe Ala His Ser Glu His Gln Tyr Pro Lys Leu Pro Glu Ser Leu Asp 
145                 150                 155                 160 


Ile Lys Gly Val Arg Phe Pro Ser Ser Phe Glu Asn Ala Leu Phe Asn 
                165                 170                 175     


Ala Asn Val Arg Thr Val Lys Asp Arg Phe Tyr Lys Asp Asp Arg Lys 
            180                 185                 190         


Asp Ala Arg Glu Ile Glu Asn Gly Phe Leu Cys Phe Arg Pro Lys Lys 
        195                 200                 205             


Thr Val Lys Asn Arg Glu Thr Val Asp Asn Pro Glu Phe Lys Phe Arg 
    210                 215                 220                 


Leu Thr Glu Arg Asn Asp Ala Asn Gly Arg Arg Tyr Pro Thr Gln Ala 
225                 230                 235                 240 


Gly Leu Ala Phe Phe Val Ala Arg Phe Leu Glu Lys Arg Tyr Val Asp 
                245                 250                 255     


Leu Leu Phe Glu Thr Thr Asp Ala Asn Gly Val Pro Val Leu Pro Leu 
            260                 265                 270         


His Arg Pro Gln Asp Val Asp Gly Val Glu Phe Ser Leu Ala Pro Arg 
        275                 280                 285             


Arg Val Tyr Gly Leu Asn Ala Ala Arg Leu Pro Arg Arg Arg Val Glu 
    290                 295                 300                 


Thr Thr Ala Arg Pro Glu Ser Ser Asn Glu Thr Leu Gly Leu Asp Leu 
305                 310                 315                 320 


Ile Gly Tyr Leu Ala Arg Cys Pro Lys Arg Val Tyr Glu Phe Leu Ser 
                325                 330                 335     


Glu Thr Asp Arg Arg Lys Phe Arg Val Ala Ala Asp Glu Ser Asn Pro 
            340                 345                 350         


Ser Glu Gly Leu Arg Thr Arg Ser Glu Lys Arg Phe Ala Arg Leu Ala 
        355                 360                 365             


Ala Leu Cys Leu Asp Arg Met Asn Cys Phe Glu Asn Leu Arg Phe Gln 
    370                 375                 380                 


Val Asp Met Gly Gln Tyr Tyr Ser Ala Thr His Arg Arg Arg Leu Ile 
385                 390                 395                 400 


Asp Gly Thr Thr Ile Asp Asp Arg Arg Val Gly Lys Arg Val Phe Trp 
                405                 410                 415     


Phe Glu Arg Ile Gln Asn Ala Val Asp Tyr Tyr Arg Ala Glu Arg Leu 
            420                 425                 430         


Lys Pro Glu Ser Lys Tyr Phe Val Pro Thr Asp Glu Ala Glu Thr Pro 
        435                 440                 445             


Pro Glu Thr Asp Tyr Arg Val Asp Ala Tyr Pro Arg Tyr Arg Val Lys 
    450                 455                 460                 


Asn Gln Gln Leu Gly Leu Arg Leu Val Asp Ala Ser Gln Lys Asn Ala 
465                 470                 475                 480 


Pro Pro Lys Leu Ile Pro Trp Thr His Ser Ala Lys Arg Gly Ser Ala 
                485                 490                 495     


Pro Lys Thr Arg Met Lys Arg Pro Glu Phe Trp Leu Ser Gln Tyr Glu 
            500                 505                 510         


Leu Pro Ala Leu Leu Phe Val Ala Leu His Gly Lys Ala Gln Asp Ala 
        515                 520                 525             


Gln Asn Val Ile Ala Asp Tyr Gln Lys Asn Trp Arg Arg Phe Leu Glu 
    530                 535                 540                 


Asp Val Arg Asp Gly Lys Phe Asp Phe Gly Gly Gly Arg Ala Leu Arg 
545                 550                 555                 560 


Glu Thr Arg Gln Thr Phe Glu Ser Gln Tyr Gly Leu Arg Phe Asp Asp 
                565                 570                 575     


Leu Pro Asp Ser Thr Arg Ala Leu Phe Arg Ser Thr Ala Ser Asp Ser 
            580                 585                 590         


Lys Glu Leu Glu Lys Lys Arg Val Asp Ala Ala Glu Gln Thr Leu Pro 
        595                 600                 605             


Glu Arg Gln Ile Asp Arg Leu Leu Asp Glu Thr Arg Arg Arg Leu Ala 
    610                 615                 620                 


Val Leu Glu Ser Glu Thr Arg Glu Val Phe Gln Leu Gly Lys Arg Lys 
625                 630                 635                 640 


Arg Pro Ser Leu Ser Val Gly Arg Val Ala Ser Cys Leu Val Arg Asp 
                645                 650                 655     


Leu Met Arg Phe Gln Tyr Ala Thr Ser Glu Lys Ser Phe Gly Lys Ile 
            660                 665                 670         


Pro Ser Ser Pro Asp Phe Ile Ala Leu Gln Thr Ser Leu Ala Cys Phe 
        675                 680                 685             


Glu Ser Arg Gln Asn Glu Leu Leu Glu Ile Phe Lys Ala Ala Lys Leu 
    690                 695                 700                 


Ile Pro Ser Asn Phe Val Ala Pro Asn Asp Ala Glu Glu Ala Phe Phe 
705                 710                 715                 720 


Phe Ala Asp Ala Gln Asn Ala Glu Arg Ser Leu His Pro Phe Leu Gly 
                725                 730                 735     


Ala Val Val Ala Asp Ala Ala Asn Leu Arg Asp Trp Lys Ser Phe Tyr 
            740                 745                 750         


Arg Ala Tyr Leu Thr Cys Arg Leu Asn Trp Leu Arg Gly Cys Ala Pro 
        755                 760                 765             


Gln Glu Leu Arg His Thr Arg Tyr Gly Asn Arg Arg Leu Glu Lys Leu 
    770                 775                 780                 


Lys Lys Met Arg Lys Ser Gly Lys Arg Gln Thr Val Ala Gln Gln Met 
785                 790                 795                 800 


Ala Thr Arg Leu Leu Glu Gln Pro Ile Asn Leu Pro Arg Gly Leu Phe 
                805                 810                 815     


Thr Asp Leu Val Arg Ala Val Val Gln Glu Arg Phe Gly Asp Gln Leu 
            820                 825                 830         


Ala Lys Ala Thr Gln Asn Gly Ala Thr Ser Thr Asn Ala Ser Trp Leu 
        835                 840                 845             


Ile Gly Lys Val Arg Asp Trp Ser Asp Asp Ala Ser Gln Gly Phe Tyr 
    850                 855                 860                 


Ser Trp Arg Arg Asp Tyr Arg Asn Val Ala Ser Phe Lys Arg Leu Phe 
865                 870                 875                 880 


Glu Leu Cys Gly Pro Thr Val Ser Thr Ser Pro Leu Ala Phe Arg Ala 
                885                 890                 895     


Leu Asn Ser Thr Ser Pro Leu Asp Phe Arg Ala Leu Lys Glu Ala Phe 
            900                 905                 910         


Asp Ala Asn Phe Asp Ala Asn Tyr Ala Ala Ala Glu Phe Ala Lys Thr 
        915                 920                 925             


Asp His Lys Thr Asp Arg Glu Asp Trp Glu Arg Phe Ile Arg Glu Ala 
    930                 935                 940                 


Glu Ala Glu Leu Arg Glu Glu Ala Leu Glu Ala Thr Arg Gly Arg Ser 
945                 950                 955                 960 


Gln Arg Arg Pro Phe Ile Pro Arg Glu Lys Ile Glu Glu Arg Ala Ser 
                965                 970                 975     


Lys Lys Arg Lys Lys Phe Ala Asp Glu Gln Lys Ala Lys Arg Arg Ala 
            980                 985                 990         


Ala Glu His Ala Lys Ile Arg Arg  Leu Ser Asp Ala Glu  Arg Asp Ile 
        995                 1000                 1005             


Arg His  Ala Glu Ile Gln Asp  Tyr Val Leu Leu Leu  Ala Ala Ser 
    1010                 1015                 1020             


Tyr Phe  Leu Phe Glu Gly Asp  Leu Ala Lys Ile Arg  Leu Ala Asp 
    1025                 1030                 1035             


Val Tyr  Ala Ile Val Asp Asp  Ala Thr Gly Thr Val  Ser Thr Asn 
    1040                 1045                 1050             


Pro Leu  Arg Lys Leu Arg Pro  Cys Glu Val Leu Val  Asp Val Pro 
    1055                 1060                 1065             


Gly Ser  Gly Thr Cys Lys Ile  Arg Gly Glu Met Asn  Val Lys Asn 
    1070                 1075                 1080             


Ser Gly  Asn Phe Gln Arg Phe  Leu Thr Asp Gly Arg  Leu Pro Ser 
    1085                 1090                 1095             


Phe Leu  Arg Ser Leu Arg Leu  Met Gln Ala Glu Asn  Ala Glu Glu 
    1100                 1105                 1110             


Leu Ser  Tyr Ile Asp Leu Ala  Asn Glu Phe Ala Ala  Ser Asp Arg 
    1115                 1120                 1125             


Leu Gln  Arg Gly Arg Ile Phe  Ala Ala Ile Tyr Arg  Phe Glu Asn 
    1130                 1135                 1140             


Ala Cys  Phe Ser Val Phe Pro  Glu Leu Lys Asp Lys  Lys Arg Gly 
    1145                 1150                 1155             


Gly Tyr  Val Ser Phe Ala Thr  Ile Leu Thr Ser Val  Phe Pro Asn 
    1160                 1165                 1170             


Asp Glu  Glu Thr Gln Tyr Arg  Leu Leu Val Ile Arg  Asn Lys Phe 
    1175                 1180                 1185             


Met His  Gln Glu Tyr Pro Ile  Tyr Asp Ala Ser Gln  Thr Lys Asp 
    1190                 1195                 1200             


Lys Gln  Arg Trp Thr Pro Ile  Phe Asp Arg Trp Asn  Arg Glu Met 
    1205                 1210                 1215             


Trp Ala  Lys Tyr Asp Pro Lys  His Gly Arg Ala Leu  Cys Gln Cys 
    1220                 1225                 1230             


Ala Val  Asp Trp Ala Glu Pro  Tyr Phe Asp Glu Ala  Thr Lys Leu 
    1235                 1240                 1245             


Val Glu  Ser Arg Arg 
    1250             


<210>  1370
<211>  1057
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1370

Met Thr Ile Lys Glu Gln Ser His Phe Ala Ala Tyr Tyr Asn Met Ala 
1               5                   10                  15      


Arg His Asn Met Tyr Glu Thr Leu Cys Tyr Ile Ser Lys Ile Ser Gly 
            20                  25                  30          


Ile Gln Glu Gly Glu Asp Asn Lys Glu Ser Lys Ile Glu Asp Met Gln 
        35                  40                  45              


Leu Leu Arg Val Leu Thr Thr Lys Gly His Pro Glu Glu Lys Ile Arg 
    50                  55                  60                  


Ile Glu Lys Leu Ile Tyr Lys His Leu Pro Leu Phe Arg Pro Ala Val 
65                  70                  75                  80  


Glu Asp Leu Arg Lys Lys Ser Lys Glu Asn Val Lys Ser Pro Glu Leu 
                85                  90                  95      


Leu Ala Lys Val Ile Lys Asn Trp Ala Lys Val Ile Thr Tyr Tyr Arg 
            100                 105                 110         


Asp Lys Phe Thr His Tyr Val Phe Ile Asp Lys Arg His Glu Asn Lys 
        115                 120                 125             


Glu Phe Leu Asn Ala Glu Met Ser Val Ala Asn Asp Leu Asn Gln Ile 
    130                 135                 140                 


Phe Thr Ala Ser Ala Arg Val Ile Lys Glu Arg Phe Gly Leu Ser Thr 
145                 150                 155                 160 


Glu Leu Glu Phe Leu Thr Lys Gly Arg Tyr Arg Thr Gln Thr Ile Asp 
                165                 170                 175     


Gly Lys Arg Ser Thr Lys Leu Asn Pro Asn Phe Ile Tyr Ser Leu Gln 
            180                 185                 190         


Asp Lys Asn Glu Arg Leu Asn Lys Met Gly Leu Ile Phe Leu Ala Cys 
        195                 200                 205             


Gln Leu Ile Glu Lys Lys Tyr Ala Ser Met Leu Phe Asp Gln Gln Gly 
    210                 215                 220                 


Tyr Met Gly Arg Asp Ile Tyr Phe Asp Phe Thr Pro Ala Gln Cys Lys 
225                 230                 235                 240 


Tyr Ile Arg Glu Val Phe Ser Ala His Arg Ile Val Leu Pro Arg Gly 
                245                 250                 255     


Arg Met Asp Val Glu Arg Asn Glu Ile Thr Ile Ala Met Asp Met Phe 
            260                 265                 270         


Asn Glu Leu Gly Lys Cys Pro Lys Glu Leu Phe Glu Ile Ile Ser Lys 
        275                 280                 285             


Glu Glu Gln Lys Arg Phe Arg Thr Lys Ser Glu Thr Thr Gly Glu Glu 
    290                 295                 300                 


Val Leu Leu Met Arg His Ser Asp Arg Phe Ala Thr Leu Ala Leu Gln 
305                 310                 315                 320 


Tyr Ile Asp Asn Arg Lys Val Phe Glu Lys Ile Arg Phe Gln Leu Ser 
                325                 330                 335     


Leu Gly Lys Tyr Arg Tyr Lys Phe Tyr Asp Lys Thr Cys Val Asp Gly 
            340                 345                 350         


Asp Thr His Val Arg Ile Leu Gln Lys Glu Leu Asn Gly Phe Gly Arg 
        355                 360                 365             


Ile Asn Glu Ile Glu Leu Leu Lys Glu Glu Lys Trp Gly Gly Leu Ile 
    370                 375                 380                 


Arg Lys Phe Glu Asp Ala Lys Ile Asp Thr Ala Glu Thr Lys Pro Tyr 
385                 390                 395                 400 


Ile Thr Asp Gln Tyr Pro Gln Tyr Leu Phe Asn Gly Asn Arg Ile Gly 
                405                 410                 415     


Ile Tyr Phe Asn Ser Ala His Gly Lys Ala Met Arg Asn Gly Ala Tyr 
            420                 425                 430         


Ile Pro Asp Ile Glu Ser Gly Ala His Cys Ile Gln Pro Ile Cys Trp 
        435                 440                 445             


Ile Ser Asn Tyr Glu Leu Pro Ala Leu Ile Phe His His Ile Leu Thr 
    450                 455                 460                 


Lys Asp Glu Lys Lys Ser Leu Thr Glu Lys Ile Ile Ile Asp Cys Val 
465                 470                 475                 480 


Glu Arg Tyr Lys Lys Leu Phe Asn Asp Ile Ala Glu Gly Lys Val Ala 
                485                 490                 495     


Arg Thr Gly Asn Ala Thr Ser Asp Phe Glu Met Ile Ser Lys Glu Tyr 
            500                 505                 510         


Gly Ile Glu Lys Ser Asp Ile Pro Arg Glu Leu Gln Asp Tyr Phe Asn 
        515                 520                 525             


Gly Thr Glu Arg Asp Gly Ile Glu Gln Tyr Ala Lys Ala Gln Ile Arg 
    530                 535                 540                 


Glu Met Ile Glu Glu Asn Arg Ile Arg Leu Glu Gln Phe Asn Ser Lys 
545                 550                 555                 560 


Leu Lys Lys Ile Glu Asp Gly Glu Val Lys Tyr Gly Lys Arg Asp Tyr 
                565                 570                 575     


Thr Glu Ile Arg Thr Gly Glu Leu Ala Gln Tyr Leu Ala Lys Asp Ile 
            580                 585                 590         


Val Met Phe Met Pro Lys Ala Lys Tyr Lys Pro Thr Ser Lys Asn Tyr 
        595                 600                 605             


Asn Val Met Gln Ala Leu Leu Ala Thr Phe Asn Gly Ser Glu Ser Gly 
    610                 615                 620                 


Ser Thr Leu Asp Glu Val Asp Asp Met Phe Asp Asn Ile Lys Ala Cys 
625                 630                 635                 640 


Tyr Trp Lys Asn Glu Ser Asp Asn His Pro Phe Leu Glu Tyr Val Leu 
                645                 650                 655     


Gly Glu Glu Pro Lys Asp Ile Ile Ala Phe Tyr Lys Ile Tyr Leu Glu 
            660                 665                 670         


Leu Arg Gly Glu Tyr Leu Asp Lys Cys Ile Lys Lys Met Asp Leu Ala 
        675                 680                 685             


Thr Ile Pro Phe Ile His Thr Glu Arg Lys Arg Trp Glu Lys Arg Asp 
    690                 695                 700                 


Glu Lys Phe Phe Lys Glu Leu Ala Gln Arg Tyr Ala Thr Gln Pro Ile 
705                 710                 715                 720 


Glu Leu Pro Arg Gly Leu Tyr Asp Arg Ala Ile Lys Glu Tyr Leu Lys 
                725                 730                 735     


Ser Lys Ser Ile Leu Glu Asp Val Ile Ala Gln Glu Gln Cys Asn Val 
            740                 745                 750         


Thr Tyr Leu Ile Ala Arg Tyr Met Gln Asp Val Leu Lys Asp Asp Ser 
        755                 760                 765             


Gln Gln Phe Tyr Ser Leu Pro Arg His Tyr Ser Cys Leu Ser Glu Lys 
    770                 775                 780                 


Asp Lys Tyr Leu Ser Leu Thr Glu Arg Glu Ala Ile Ala Lys Ser Asp 
785                 790                 795                 800 


Ala Leu Asn Ser Phe Lys Lys Arg Glu Arg Glu Lys Glu Asn Glu Asn 
                805                 810                 815     


Arg Arg Gly Asn Arg Arg Tyr Asn Lys Gly Glu Asn Lys Asn Thr Ile 
            820                 825                 830         


Lys Asp Arg Asp Thr Glu Glu Lys Phe Asn Ser Leu Tyr Arg Lys Met 
        835                 840                 845             


Asp Asn Asn Glu Arg Ile Leu Arg Arg Tyr Lys Val Gln Asp Met Leu 
    850                 855                 860                 


Leu Tyr Leu Leu Ala Cys Asp Ile Ile Lys Gly Ile Met Arg Glu Asp 
865                 870                 875                 880 


Phe Gly Tyr Lys Leu Ser Met Ile Thr Asp Gly Lys Asn Ser Asn Phe 
                885                 890                 895     


Phe Asp Tyr Lys Met Pro Glu Phe Lys Thr Thr Ile Thr Leu Lys Glu 
            900                 905                 910         


Gly Lys Lys Phe Thr Ile Lys Gln Gln Tyr Leu Lys Ile Lys Asn Tyr 
        915                 920                 925             


Gly Asp Phe Leu Lys Phe Ile Phe Asp Leu Arg Ile Asp Ser Leu Leu 
    930                 935                 940                 


Ser Asn Gly Thr Lys Val Glu Ile Asp Arg Asn Ile Leu Glu Asp Glu 
945                 950                 955                 960 


Leu Ser Asn Tyr Asp Gly Ser Arg Pro Lys Val Phe Glu Thr Leu Leu 
                965                 970                 975     


Met Ile Glu Lys Ile Val Val Glu Lys His Lys Glu Leu Lys Asp Leu 
            980                 985                 990         


Glu His Ile Thr Phe Gly Asp Val  Leu Asn Val Ile Lys  Met Glu Glu 
        995                 1000                 1005             


Gly Glu  Lys Lys Ile Leu Arg  Leu Ile Arg Asn Ala  Phe Ser His 
    1010                 1015                 1020             


Asn Tyr  Tyr Pro Thr Ile Lys  Asp Val Asn Tyr Asp  Asn Met Pro 
    1025                 1030                 1035             


Glu Val  Ala Glu Ser Leu Lys  Asp Ile Leu Glu Lys  Glu Ser Lys 
    1040                 1045                 1050             


Lys Leu  Thr Asn 
    1055         


<210>  1371
<211>  1199
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1371

Met Asn Thr Phe Ile Asp Ser Phe Ile Arg Arg Val Gln Ile Gln Asn 
1               5                   10                  15      


Gln Asn Gln Ser Trp Pro Lys Arg Pro Lys Tyr Val Arg Pro Val Glu 
            20                  25                  30          


Asn Ile Arg Pro Asp Asp Leu Ala Phe Gln Ser His Phe Thr Ala Tyr 
        35                  40                  45              


Leu Asn Met Ala Arg Gln Asn Cys Cys Ile Ile Leu Gly His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Gly Phe Lys Ala Ser Ser Val Lys Asp Thr Thr Leu Thr 
65                  70                  75                  80  


Ser Ser Pro Leu Leu Gly Gln Asn Gly Leu Leu Ser Pro Lys Lys Glu 
                85                  90                  95      


Val Ser Asp Leu Ile Arg Gly Arg Leu Leu Ser Ala Phe Pro Met Leu 
            100                 105                 110         


Asp Pro Met Ile Arg Tyr Arg Lys Ala Val Asp Lys Glu Lys Asp Asp 
        115                 120                 125             


Tyr Ala Arg Ile Ile Ile Thr Ser Glu Asp Val Ser Glu Met Leu Arg 
    130                 135                 140                 


Asp Leu Leu Asp Val Leu Ser Tyr Tyr Arg Asp Met Ala Ser His Val 
145                 150                 155                 160 


Val Phe Asn Asp Asp Arg Ser Val Ser Ala Glu Phe Ala Ser Lys Glu 
                165                 170                 175     


Lys Lys Val Ala Glu Cys Leu Asn Tyr Met Met Thr Val Ser Leu Arg 
            180                 185                 190         


Ile Val Lys Asp Arg Phe Ser Leu Ala Val Ser Asp Leu Asp Phe Tyr 
        195                 200                 205             


Asn Arg Asn Arg Tyr Met Met Val Asn Arg Lys Pro Leu Leu Asn Ala 
    210                 215                 220                 


Gly Phe Ala His Ala Val Arg Thr Glu Asp Tyr Arg Leu Thr Leu Met 
225                 230                 235                 240 


Gly Leu Val Leu Leu Cys Cys Gln Phe Ile Glu Lys Gln Tyr Ala Ser 
                245                 250                 255     


Met Phe Phe Asp Ala Leu Asp Lys His Ser Asn Gly Ala Arg Phe Tyr 
            260                 265                 270         


Gly Ile Ala Asp Ala Met Pro Met Val Asn Val Gly Thr Lys Asp Lys 
        275                 280                 285             


Pro Lys Lys Ile Pro Met Tyr Thr Gly Asp Glu Ala Gln Lys Gln Val 
    290                 295                 300                 


Gln Lys Gln Arg Met Ala Leu Arg Glu Ala Tyr Ser Val Tyr Arg Val 
305                 310                 315                 320 


Arg Ile Pro Lys Glu Arg Leu Glu Ser Thr Arg Ser Asp Met Ala Leu 
                325                 330                 335     


Ala Leu Asp Ile Leu Asn Glu Leu Gly Lys Cys Pro Glu Glu Leu Phe 
            340                 345                 350         


Glu His Leu Ser Pro Glu Asp Arg Glu Ser Phe Lys Asn Glu Glu Gly 
        355                 360                 365             


Val Leu Met Lys Arg Tyr Ser Asp Arg Phe Pro Gln Leu Ala Leu Arg 
    370                 375                 380                 


Trp Leu Asp Glu Asn Glu Lys Phe Asn Asn Leu Arg Phe His Val Thr 
385                 390                 395                 400 


Phe Gly Lys Tyr Arg Trp Leu Phe Cys Gln Asp Lys Lys Cys Ala Asp 
                405                 410                 415     


Gly Ser Val Arg Pro Arg Trp Leu Gln Lys Glu Leu Asn Gly Phe Gly 
            420                 425                 430         


Arg Ile Gln Thr Val Glu Arg Lys Arg Thr Gly Leu Glu Pro Gly Trp 
        435                 440                 445             


Asp Gly Thr Gly Leu Ile Arg Lys Phe Glu Glu Val Val Thr Asp Glu 
    450                 455                 460                 


Val Gln Lys Glu Pro Tyr Ile Thr Asp Phe Arg Thr Gln Tyr Leu Phe 
465                 470                 475                 480 


Asn Arg Asp Lys Ile Gly Ile Ser Leu Ser Glu Tyr Met Pro Gly Ile 
                485                 490                 495     


Gly Asp Ile His Ser Gly Lys Glu Trp Gly Lys His Ala Gly Val Pro 
            500                 505                 510         


Asp Phe Tyr Leu Ser Val Tyr Asp Ile Pro Ala Met Leu Phe Leu Thr 
        515                 520                 525             


Trp Leu Leu Gly Lys Asn Ser Ser Ala Val Glu Lys Leu Leu Ala Asn 
    530                 535                 540                 


Cys Lys Ala Ala Tyr Met Lys Leu Phe Asp Asp Leu Ala Lys Gly Lys 
545                 550                 555                 560 


Trp Glu Gly Glu Arg Asn Val Ser Asp Tyr Cys Ala Gly Glu Gly Thr 
                565                 570                 575     


Val Arg Tyr Thr Leu Arg Trp Tyr Asp Val Pro Met Lys Ile Arg Arg 
            580                 585                 590         


Lys Met Pro Leu Leu Gly Gly Asp Arg Asp Phe Glu Glu Lys Lys Ser 
        595                 600                 605             


Phe Glu Thr Leu Ala Gln Glu Ala Leu Thr Arg Met Leu Gln Arg Thr 
    610                 615                 620                 


Glu Asn Gln Leu Glu Lys Phe Asp Arg Asp Leu Ala Ala Ala Arg Asp 
625                 630                 635                 640 


Leu Lys Ala Asn Lys Gln Gly Lys Asp Arg Phe Val Asp Ile Arg Ala 
                645                 650                 655     


Gly Ser Leu Ala Thr Phe Leu Ala Arg Asp Ile Val Arg Leu Met Pro 
            660                 665                 670         


Val Ser Asp Asn Gly Arg Asn Lys Pro Thr Gly Leu Asn Tyr Ser Ile 
        675                 680                 685             


Val Gln Lys Ala Ile Ala Thr Tyr Lys Pro Ser Glu Gly Gly Leu Asp 
    690                 695                 700                 


Thr Leu Thr Gly Val Phe Arg Asp Ala Arg Ile Ile Gly Val Lys Gly 
705                 710                 715                 720 


Gly Ser His Pro Phe Leu Glu Arg Leu Leu Val Glu Lys Lys Pro Ser 
                725                 730                 735     


Ser Val Leu Ala Leu Tyr Arg His Tyr Leu Glu Tyr Arg Lys Glu Tyr 
            740                 745                 750         


Leu Lys Lys Ala Leu Glu Asp Glu Asn Lys Ala Glu Leu Lys Asn Leu 
        755                 760                 765             


Pro Phe Leu Lys Ser Gly Arg Gln Lys Tyr Ala Val Asp Gln Ala Asp 
    770                 775                 780                 


Tyr Ala Arg Arg Leu Ala Glu Ser Tyr Arg Asn Cys Pro Ile Tyr Leu 
785                 790                 795                 800 


Pro Thr Gly Ile Phe Thr Asp Met Leu Lys Asp Gln Leu Ala Lys Ile 
                805                 810                 815     


Asp Val Met Lys Pro Val Leu Glu Asn Asp Lys Val Asn Ala Ser Tyr 
            820                 825                 830         


Leu Ile Ala Gln Tyr Phe Glu Lys Val Glu His Asp Ser Glu Gln Pro 
        835                 840                 845             


Leu Tyr Arg Leu Lys Arg Asn Tyr Arg Val Phe Asp Leu Leu Glu Phe 
    850                 855                 860                 


Thr Asp Glu Pro Lys Tyr Trp Arg Leu Asn Glu Arg Ser Asp Lys Ala 
865                 870                 875                 880 


Gly Lys Tyr Gly Leu Ala Lys Arg Asn Ile Phe Trp Asn Arg Met Gly 
                885                 890                 895     


Glu Tyr Tyr Lys Gly Leu Lys Lys Phe Tyr Lys Gly Tyr Glu Ser Lys 
            900                 905                 910         


Arg Thr Ala Val Asp Trp Arg Glu Lys Leu Lys Ile Val Glu Ala Glu 
        915                 920                 925             


His Ala Met Trp Asn Arg Leu Lys Asp Ala Ser Gly Glu Ala Arg Leu 
    930                 935                 940                 


Lys Met Lys Asp Gly Val Phe Tyr Ser Arg Leu Leu Ser Ala Arg Lys 
945                 950                 955                 960 


Glu Tyr Asp Asp Cys Glu Arg Ala Leu Arg Arg Leu Lys Val Gln Asp 
                965                 970                 975     


Ile Val Leu Phe Leu Ala Ala Arg Glu Thr Leu Ile Leu Pro Lys Asp 
            980                 985                 990         


Lys Val Phe Arg Leu Lys Asn Leu  Ser Leu Ser Glu Gly  Asn Lys Asn 
        995                 1000                 1005             


Ile Leu  Ser Ser Ala Ile Asp  Glu Phe Ser Val Asp  Val Val Trp 
    1010                 1015                 1020             


Thr Glu  Lys Glu Gly Ala Ala  Lys Val Thr His Ser  Ala Ser Ile 
    1025                 1030                 1035             


Lys Glu  Asn Asp Val Val Ile  Lys Asn Tyr Gly Arg  Met Phe Arg 
    1040                 1045                 1050             


Leu Leu  His Asp Asp Arg Val  Lys Thr Leu Leu Pro  His Ile Tyr 
    1055                 1060                 1065             


Asp Ser  Ala Leu Ser Glu Asn  Ile Thr Gly Asp Arg  Ile Thr Val 
    1070                 1075                 1080             


Lys Asp  Asn Lys Val Ile Ile  Asp Lys Ser Leu Phe  Asp Glu Asp 
    1085                 1090                 1095             


Leu Met  Asn Tyr Asp Leu Arg  Arg His Glu Ile Cys  Glu Ile Ile 
    1100                 1105                 1110             


Leu Arg  Phe Glu Ala Ala Ser  Ile Lys Arg Phe Gly  Leu Asp Gly 
    1115                 1120                 1125             


Arg Val  Asp Phe Lys Ala Ala  Leu Asp Ala Leu Thr  Gly Arg Ser 
    1130                 1135                 1140             


Leu Leu  Asn Asp Glu Asp Ala  Arg Ile Leu Ser Ala  Ile Arg Asn 
    1145                 1150                 1155             


Ala Tyr  Asn His Asn Lys Tyr  Pro Ala Lys Gly Thr  Asp Val Lys 
    1160                 1165                 1170             


Val Asn  Val Met Ala Leu Pro  Lys Leu Thr Glu Asp  Leu Leu Arg 
    1175                 1180                 1185             


Ile Phe  Ser Asp Thr Gly Asn  Asn Arg Val Arg 
    1190                 1195                 


<210>  1372
<211>  1081
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1372

Met Gln Ala Gln Ser Leu Phe Asp Glu Tyr Lys His Leu Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Val Met Ser Ile Met Asn Ile Ile Thr Val Leu Asn His Ile 
            20                  25                  30          


His Gln Ile Ala Gly Leu Lys Arg Asn Glu Leu Gly Asp Asp Asp Asn 
        35                  40                  45              


Ile Tyr Ser His Pro Val Leu Lys Tyr Ile Ala Pro Glu Asn Asn Ser 
    50                  55                  60                  


Thr Thr Leu Pro Glu Lys Arg Asp Leu Ile Lys Glu Leu Leu Leu Glu 
65                  70                  75                  80  


Tyr Leu Pro Phe Leu Glu Ala Met Lys Asp Cys Tyr Lys Glu Val Lys 
                85                  90                  95      


Val Glu Lys Asp Lys Arg Asn Asn Lys Tyr Val Lys Asp Lys Lys Gln 
            100                 105                 110         


Val Phe Ile Arg Asn Tyr Ser Asp Ile Tyr Cys Ile Tyr Trp Thr Leu 
        115                 120                 125             


Tyr Asn Ile Phe Ser Thr Leu Ile Asn Tyr Arg Asp Lys Ser Cys His 
    130                 135                 140                 


Tyr Arg Phe Ile Pro Ser Lys Asp Gln Glu Glu Tyr Ser Lys Arg Thr 
145                 150                 155                 160 


Glu Tyr Asp Thr Val Arg Ile Ile Asn Lys Tyr Tyr Thr Tyr Ala Leu 
                165                 170                 175     


Arg Lys Thr Lys Glu Lys Tyr Gly Tyr Thr Thr Glu Gln Leu Ser Phe 
            180                 185                 190         


Ile Gln Asn Asn Arg Tyr Thr Asp Asp Lys Lys Val Asn Phe Asn Phe 
        195                 200                 205             


Phe Leu Ser Met Gln Ser Ser Asn Asn Asn Leu Ser His Val Gly Val 
    210                 215                 220                 


Ala Gln Leu Ile Cys Leu Phe Leu Gln Lys Lys Asp Val Asp Asn Phe 
225                 230                 235                 240 


Leu Glu Asn Leu Pro Ile Tyr Asp Asn Arg Tyr Cys Leu Gly Ile Asp 
                245                 250                 255     


Glu His Met Ile Ile Lys Arg Ser Leu Ala Leu His Ser Ile Lys Leu 
            260                 265                 270         


Pro Lys Glu Arg Leu Asn Ser Glu Lys Lys Asp Met Ala Ile Ala Met 
        275                 280                 285             


Asp Met Leu Asn Glu Leu Lys Arg Cys Pro Lys Glu Leu Phe Asn Thr 
    290                 295                 300                 


Leu Pro Phe Asp Lys Gln Glu Arg Phe Arg Ile Ile Ser Ser Asp His 
305                 310                 315                 320 


Lys Glu Val Leu Leu Met Arg Ser Thr Asp Arg Phe Val Pro Leu Ile 
                325                 330                 335     


Leu Gln Tyr Ile Asp Cys Asn Lys Lys Phe Lys Asp Ile Arg Phe His 
            340                 345                 350         


Val Asn Met Gly Lys Leu Arg Tyr Leu Phe Ser Pro Asn Lys Leu Cys 
        355                 360                 365             


Ile Asp Asn Gln Glu Arg Val Arg Met Leu Glu His Leu Leu Asn Gly 
    370                 375                 380                 


Tyr Gly Arg Ile Asp Glu Val Glu Tyr Leu Arg Lys Ala Pro Asn Gly 
385                 390                 395                 400 


Thr Phe Gly Asn Thr Asn Ile Pro Ile Lys Gly Phe Gly Glu Ile Glu 
                405                 410                 415     


Arg Asp Ser Ala Asp Ser Asn Asn Tyr Pro Tyr Ile Val Asp Thr His 
            420                 425                 430         


Thr His Tyr Ile Leu Asn Asn Asn Lys Val Glu Phe Cys Phe Cys Glu 
        435                 440                 445             


Asp Ser Lys Asn Lys Asn Val Phe Pro Thr Ile Glu Lys Glu Ile Asn 
    450                 455                 460                 


Gly Lys Trp Tyr Val Glu Lys Thr Ala Pro His Cys Arg Ile Ser Phe 
465                 470                 475                 480 


Phe Glu Ile Pro Ala Met Ala Phe His Met Phe Leu Cys Gly Ser Glu 
                485                 490                 495     


Lys Thr Glu Lys Leu Ile Lys Asp Val Tyr Asn Asn Tyr Ile Ser Leu 
            500                 505                 510         


Phe Asn Ala Leu Lys Asn Gly Ala Leu Thr Glu Glu Asn Tyr Lys Asp 
        515                 520                 525             


Phe Asn Ile Pro Glu Cys Asp Met Pro Lys Lys Ile Leu Asp Phe Leu 
    530                 535                 540                 


Lys Gly Lys Ala Glu Gly Lys Ser Ile Asp Gly Tyr Val Lys Asn Ile 
545                 550                 555                 560 


Leu Lys Lys Glu Leu Lys Asp Thr Arg Lys Arg Ile Glu Gln Ala Pro 
                565                 570                 575     


Ser Glu Lys Asp Gln Met Pro Ser Lys Arg Asn Lys Ile Gly Thr Lys 
            580                 585                 590         


Ser Tyr Lys Arg Val Leu Thr Gly Lys Leu Ala Asp Phe Leu Ala Lys 
        595                 600                 605             


Asp Ile Val Lys Tyr Gln Pro Thr Leu Cys Ala Gly Asp Asp Tyr Gly 
    610                 615                 620                 


Ile Asp Arg Met Thr Gly Met Asn Tyr Arg Ile Met Gln Ala Thr Ile 
625                 630                 635                 640 


Ala Thr Tyr Asn Asp Asp Asp Asp Phe Asp Thr Phe Tyr Asn Val Phe 
                645                 650                 655     


Lys Met Ala Gly Leu Val Asp Gly Asp Glu Arg Lys Asn His Pro Phe 
            660                 665                 670         


Leu Lys Lys Val Leu Leu Ser Lys Pro Gln Asn Thr Val Ala Phe Asn 
        675                 680                 685             


Ile Lys Tyr Leu Lys Glu Lys Glu Ile Tyr Leu Arg Asn Ile Glu Lys 
    690                 695                 700                 


Lys Asn Ile Ile Pro Pro Phe Val Asn Arg Glu Arg Asn Lys Trp Cys 
705                 710                 715                 720 


Glu Arg Asp Cys Glu Tyr Tyr Arg Ile Leu Gly Glu Asn Leu Leu Asp 
                725                 730                 735     


Leu Pro Ile Glu Leu Pro Arg Gln Met Phe Tyr Lys Asp Ile Arg Ala 
            740                 745                 750         


Gln Leu Glu Pro Leu Met Pro Glu Ile Asp Phe Ser Gln Thr Asn Thr 
        755                 760                 765             


Thr Tyr Leu Ile Ala Glu Tyr Leu Lys Arg Val Arg Gly Asp Asp Phe 
    770                 775                 780                 


Gln Glu Phe Tyr Ser Trp Glu Arg Asn Tyr Arg Tyr Ile Asp Phe Leu 
785                 790                 795                 800 


Lys Cys Ile Arg Asp Asp Asn Gly Arg Ile Cys Ala Gln Tyr Thr Thr 
                805                 810                 815     


Thr Glu Glu Arg Glu Ser Leu Trp Glu Asp Ser Lys Asn Arg Thr Ala 
            820                 825                 830         


Glu Tyr Lys Arg Ser Glu Glu Gln Lys Asn Glu Lys Lys Asp Lys Asn 
        835                 840                 845             


Phe Glu Asp Ser Leu Glu Glu Arg Ile Ser Ser Ser His Ile Lys Phe 
    850                 855                 860                 


Gln Asn Thr Glu Lys His Ile Arg Arg Tyr Lys Val Gln Asp Ala Leu 
865                 870                 875                 880 


Leu Phe Met Ile Ala Glu Lys Gln Phe Gly Lys Tyr Leu Asp Asp Ile 
                885                 890                 895     


Lys Ala Lys Asn Phe Lys Leu Lys Asp Ile Met Pro Asp Thr Asp Lys 
            900                 905                 910         


Gly Ile Leu Ser Glu Thr Met Pro Ile Asp Phe Thr Phe Thr Lys Lys 
        915                 920                 925             


Asn Ile Lys Tyr Asn Ile His Ala Lys Asn Leu Lys Phe Lys Glu Tyr 
    930                 935                 940                 


Gly Asp Leu Phe Ile Leu Ala Asn Asp Lys Arg Leu Glu Ser Leu Trp 
945                 950                 955                 960 


Lys Ile Leu Ala Thr Asp Thr Val Asn Lys Glu Glu Ile Ser Glu Glu 
                965                 970                 975     


Phe Ala Lys Tyr Asp Phe Cys Arg Pro Asp Ile Thr Lys Leu Val Leu 
            980                 985                 990         


Asp Phe Glu Lys Asp Val Leu Glu  Lys Tyr Pro Glu Ile  Ile Glu Glu 
        995                 1000                 1005             


Ala Glu  Lys Glu Tyr Lys Lys  Phe Asp Phe Lys Phe  Ile Leu Asp 
    1010                 1015                 1020             


Trp Leu  Ile Asn Lys Lys Lys  Leu Asn Tyr Gly Ile  Arg Asn Lys 
    1025                 1030                 1035             


Leu Leu  Leu Ile Arg Asn Ala  Phe Asn His Asn Ser  Tyr Pro Asp 
    1040                 1045                 1050             


Lys Lys  Tyr Ala Glu Val Arg  Glu Leu Pro Glu Ile  Ala Thr Asn 
    1055                 1060                 1065             


Leu Lys  Lys Thr Phe Asp Glu  Asn Ala Lys Lys Tyr  Glu 
    1070                 1075                 1080     


<210>  1373
<211>  1128
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1373

Met Glu Ile Leu Thr Ile Pro Glu Val Ile Lys Cys Arg Thr Leu Ser 
1               5                   10                  15      


Asp Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Val Leu Asn Ile Ser Asn His Ile Ala Lys Glu Phe Lys Leu Pro Leu 
        35                  40                  45              


Leu Pro Glu Glu Ala His Leu Lys Asn Ser Phe Leu Cys Lys Lys Glu 
    50                  55                  60                  


Asn Lys Lys Ile Asp Trp Asn His Val Tyr Ala Arg Thr Ile Arg Phe 
65                  70                  75                  80  


Leu Ser Val Met Lys Val Phe Asp Ala Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Lys Thr Ile Asp Trp Glu Gly Lys Asp Phe Ala Ser Met Cys Asp 
            100                 105                 110         


Thr Leu Asn Ile Val Phe Ser Glu Leu Gln Glu Phe Ser Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Glu Thr Lys Arg Lys Thr Thr Val 
    130                 135                 140                 


Ser Asp Glu Leu Ala Leu Phe Leu Arg Thr Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Glu Tyr Thr Lys Val Arg Phe Lys Gly Ile Leu Asn Asp Glu Asp Tyr 
                165                 170                 175     


Gln Leu Val Val Ser Lys Lys Met Leu Glu Thr Asn His Thr Ile Thr 
            180                 185                 190         


His Glu Gly Leu Val Phe Leu Thr Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Arg Phe Ile Arg Lys Ile His Gly Leu Ser Gly Pro Lys Asp 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Cys Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro Gln Glu Gln Phe Arg Ser Asp Asn Arg Arg Gln Ala Ile Ser 
                245                 250                 255     


Leu Glu Leu Met Asn Glu Leu Lys Lys Cys Pro Lys Val Leu Tyr His 
            260                 265                 270         


Val Ile Thr Glu Glu Trp Lys Gln Lys Leu Lys Ser Val Pro Glu Glu 
        275                 280                 285             


Leu Glu Thr Lys Asn Leu His Tyr Asn Thr Lys Lys Glu Ala Ile Ile 
    290                 295                 300                 


Glu Phe Glu Asp Tyr Asp Leu Tyr Ile Glu Ser Leu Thr Lys Gln Val 
305                 310                 315                 320 


Arg Tyr Asn Asn Arg Phe Ser Glu Phe Ala Leu Lys Tyr Ile Asp Glu 
                325                 330                 335     


Thr Gly Ile Phe Ser Glu Phe Arg Phe Gln Ile Asp Leu Gly Lys Ile 
            340                 345                 350         


Leu Val Asp Glu Tyr Leu Lys Asn Phe Asn Asp Glu Arg Val Gln Arg 
        355                 360                 365             


Cys Ile Ile Glu Asn Ala Lys Ala Phe Gly Lys Leu Asn Asp Tyr Thr 
    370                 375                 380                 


Asn Glu Thr Lys Val Met Ser Leu Ile Val Asn Gly Pro Pro Leu Lys 
385                 390                 395                 400 


Ser Phe Asp Arg Phe Ala Pro His Tyr Asn Ile Glu Ser Asn Lys Ile 
                405                 410                 415     


Gly Ile Ser Thr His Glu Val Thr Ala Lys Leu Val Pro Asn Ser Lys 
            420                 425                 430         


Gly Glu Pro Ala Lys Lys Leu His Gln Pro Leu Pro Glu Ala Phe Leu 
        435                 440                 445             


Ser Leu His Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu Gln Lys 
    450                 455                 460                 


Gly Glu Pro Glu Lys Leu Ile Asn Glu Phe Ile Leu Val Asn Asn Ser 
465                 470                 475                 480 


Lys Leu Met Asn Met Ser Phe Ile Glu Glu Val Lys Asn Gln Leu Pro 
                485                 490                 495     


Lys Glu Trp Asp Lys Phe Gln Arg Arg Thr Asn Ala Lys His Glu Leu 
            500                 505                 510         


Ala Tyr Asp Glu Asn Thr Leu Ala Phe Leu Leu Gln Arg Lys Gln Ile 
        515                 520                 525             


Leu Asn Lys Thr Leu Leu Ala Tyr Gln Leu Asn Asp Lys Gln Ile Pro 
    530                 535                 540                 


Thr Arg Ile Leu Asp Tyr Trp Leu Asn Ile Ser Asp Ala Asp Glu Glu 
545                 550                 555                 560 


Arg Ala Ile Ser Asn Arg Leu Lys Ser Ile Lys Arg Asp Cys Met Ser 
                565                 570                 575     


Arg Leu Lys Ala Leu Ser Lys Phe Asn Glu Asn Gly Asn Arg Asn Lys 
            580                 585                 590         


Ile Pro Gly Ile Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile Ile 
        595                 600                 605             


Glu Met Val Val Ser Glu Gly Lys Lys Arg Lys Ile Thr Ser Phe Tyr 
    610                 615                 620                 


Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Gly Asp Pro Asp Lys 
625                 630                 635                 640 


Lys Gln Leu Phe Ile His Ile Val Thr Lys Glu Leu Lys Leu Asn Asp 
                645                 650                 655     


Pro Gly Gly His Pro Phe Leu Asp Lys Leu Asp Leu Gln Lys Ile Asn 
            660                 665                 670         


Ser Thr Thr Gly Phe Tyr Glu Ile Tyr Leu Gln Glu Lys Gly His Lys 
        675                 680                 685             


Met Val Pro Glu Asn Asn Pro Lys Thr Gly Lys Val Ile Tyr Thr Asp 
    690                 695                 700                 


His Ser Trp Met Ala Leu Thr Phe Tyr Lys Ile Glu Phe Asn Asp Lys 
705                 710                 715                 720 


Val Asp Met Leu Met Thr Val Val Lys Leu Pro Leu Lys Lys Leu Asn 
                725                 730                 735     


Ile Pro Phe Thr Leu Arg Gln Leu Ser Gly Lys Thr Asn Asn Thr Leu 
            740                 745                 750         


Lys Gln Trp Leu Asn Asn Leu Thr Gln Gly Lys Lys Arg Asn Asp Gly 
        755                 760                 765             


Lys Arg Pro Ile Asn Leu Pro Thr Asn Leu Phe Asp Glu Arg Leu Ala 
    770                 775                 780                 


Glu Leu Leu Arg Lys Asp Leu Asp Asn Lys Lys Ile Val Tyr Trp Pro 
785                 790                 795                 800 


Tyr Ala Asn Trp Asn Glu Leu Phe Lys Thr Trp Trp Ser Ser Arg Asn 
                805                 810                 815     


Asp Gly Leu Gln Ser Phe Tyr Asn Ala Glu Arg Glu Tyr Arg Ile Phe 
            820                 825                 830         


Asp Glu Lys Val Asn Phe Tyr Pro Asn Arg Lys Glu Asn Phe Ala Asp 
        835                 840                 845             


Tyr Tyr Gln His Ala Leu Lys Leu Ala Phe Gln Lys Lys Gln Ser Lys 
    850                 855                 860                 


Arg Ile Leu Glu Gln Met Tyr Asp Gln His Leu Pro Asp Ile Leu Phe 
865                 870                 875                 880 


Asp Gln Val Glu Lys Thr Phe Arg His Thr Ile Ala Glu Thr Glu Lys 
                885                 890                 895     


Glu Ile Arg Ile Leu Gln Glu Glu Asp His Ile Met Leu Leu Met Leu 
            900                 905                 910         


Glu Ser Leu Leu Asp Asp Gly Ser Lys Gln Gln Leu Lys Leu Ser Glu 
        915                 920                 925             


Ile Arg Thr His Leu Asn Arg Thr Thr Asn Ile Arg Gln Val Val Lys 
    930                 935                 940                 


Gly Lys Leu Ser Phe Asp Asp Ser Gly Glu Leu Ile Lys Asp Asn Thr 
945                 950                 955                 960 


Lys Pro Glu Ile Val Arg Thr Val Ser Val Thr Asp Gln Arg Lys Lys 
                965                 970                 975     


Leu His Gln Leu Pro Lys Leu Ile Phe Asp Ser Arg Leu Pro Glu Leu 
            980                 985                 990         


Leu Glu Tyr Phe Pro Asp Glu Glu  Ile Gln Met Glu Ser  Leu Lys Lys 
        995                 1000                 1005             


Glu Phe  Asp Thr Tyr Asn Thr  Thr Arg Gln Val Val  Leu Asn Leu 
    1010                 1015                 1020             


Ser Phe  Asn Leu Glu Lys Met  Ile Ile Glu Lys Gly  Arg Leu Asp 
    1025                 1030                 1035             


Arg Ile  Asn Glu Leu Leu Ser  Ser Ala Thr Gly Asp  Leu Leu Thr 
    1040                 1045                 1050             


Gly His  Ile Gly His Lys Thr  Tyr Leu Thr Trp Leu  Lys Asn Arg 
    1055                 1060                 1065             


Gly Ile  Ile Asp Asn Asp Thr  Phe Ile Phe Met Asn  Met Val Gln 
    1070                 1075                 1080             


Tyr Cys  Phe Ser His Asn Gln  Tyr Pro Gln Lys Lys  Thr Met Ala 
    1085                 1090                 1095             


Arg Leu  Ile Ser Arg Trp Asp  Gln His Arg Phe Ala  Leu Gln Ile 
    1100                 1105                 1110             


Glu Ala  Thr Tyr Ile Gln Lys  Ile Ala Gly Ile Ile  Glu Asp Leu 
    1115                 1120                 1125             


<210>  1374
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1374

Met Glu Thr Lys Gln Gln Val Gly Lys Gly Ile Ser Tyr Asp His Arg 
1               5                   10                  15      


Arg Pro Asp Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asp Gly Val Ile Gln Glu Phe Ala Met Arg Leu Asn Arg 
        35                  40                  45              


Glu Tyr Asp Pro Glu Asn Lys Asn Gln Ser Leu Phe Ser Tyr Phe Asn 
    50                  55                  60                  


Ile Asn Ala Ser Phe Thr Asp Trp Glu Arg Gly Val Asn Ile Leu Lys 
65                  70                  75                  80  


Glu Tyr Trp Pro Met Met Glu Phe Ile Asp Arg Pro Ala Thr Asp Lys 
                85                  90                  95      


Gln Phe Glu Ala Glu Lys Pro Glu Asn Arg Glu Ala Ala Lys Arg Lys 
            100                 105                 110         


Tyr Phe Leu Ala Thr Leu Gly Ala Leu Leu Thr Ser Ile Lys Asp Leu 
        115                 120                 125             


Arg His Tyr Tyr Thr His Tyr Tyr His Pro Pro Val His Leu Asn Asp 
    130                 135                 140                 


Asp Leu Phe Leu Phe Leu Asp His Ala Leu Leu Tyr Thr Ala Phe Asp 
145                 150                 155                 160 


Val Lys Lys Thr Lys Met Lys Asp Asp Lys Thr Arg Gln Leu Leu Asn 
                165                 170                 175     


Gln Asn Leu Ser Leu Glu Leu Glu Lys Leu Lys Lys Leu Lys Val Glu 
            180                 185                 190         


Glu Leu Lys Lys Lys Lys Glu Lys Gly Ile Lys Val Asn Leu Gln Asp 
        195                 200                 205             


Glu Lys Gly Ile Leu Asn Ala Ile Tyr Asn Asp Ala Phe Ala His Ile 
    210                 215                 220                 


Ile Thr Lys Glu Lys Asp Ser Asp Lys Asp Lys Leu Glu Thr Arg Tyr 
225                 230                 235                 240 


Lys Ser Ile Leu Pro Gln Asp Glu Ala Ala Glu Thr Gly Ile Asn Ile 
                245                 250                 255     


Ser Ile Ser Gly Leu Ile Phe Leu Leu Ser Leu Phe Leu Ser Arg Lys 
            260                 265                 270         


Glu Ile Glu Gln Leu Lys Ser Asn Ile Glu Gly Tyr Lys Gly Lys Val 
        275                 280                 285             


Leu Asn Ile Glu Thr Glu Val Asp Arg Lys His Asn Ser Leu Lys Tyr 
    290                 295                 300                 


Met Ala Thr His Trp Val Phe Ser Ile Leu Ala Phe Lys Gly Leu Lys 
305                 310                 315                 320 


Gln Arg Leu Thr Asn Ser Phe Glu Lys Glu Ser Leu Leu Ile Gln Met 
                325                 330                 335     


Met Asp Glu Leu Asn Lys Val Pro Asp Glu Leu Tyr Gln Thr Leu Ser 
            340                 345                 350         


Glu Thr Ala Lys Lys Glu Phe Leu Glu Asp Ile Asn Glu Tyr Val Ser 
        355                 360                 365             


Glu Gly Asp Asp Asn Glu Lys Ala Thr Tyr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Ser Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gln Phe Pro Thr Leu Lys Phe Gln Ile Phe Val Gly 
                405                 410                 415     


Gln Tyr Leu His Asp Asn Arg Pro Lys Thr Leu Ala Ser Asn Gly Met 
            420                 425                 430         


Thr Ala Gln Arg Met Ile Lys Glu Lys Ile Asn Leu Phe Gly Asn Leu 
        435                 440                 445             


Ser Glu Val Thr Lys His Lys Ser Asp Phe Phe Glu Lys Glu Ser Ala 
    450                 455                 460                 


Ala Gln Gly Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Trp Ala Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Val Tyr Ile Asp Met Ile Gly Lys Glu Gly Lys Ala 
                485                 490                 495     


Lys Glu Ile Gln Val Gln Ile Asn Lys Tyr Arg Lys Gln Leu Asn Pro 
            500                 505                 510         


Ala Pro Gln Arg Asp Lys Arg Ile Ser Lys Lys Glu Ile Ile Glu Gln 
        515                 520                 525             


Leu Tyr Lys Glu Lys Val Val Tyr Gly Asp Pro Thr Leu Met Leu Ser 
    530                 535                 540                 


Ala Asn Glu Leu Met Ala Leu Leu Tyr Glu Leu Ile Val Asn Gly Lys 
545                 550                 555                 560 


Ser Gly Ala Glu Leu Glu Asn Lys Ile Val Glu Gln Ile Ile Ala Arg 
                565                 570                 575     


Tyr Glu Gln Ile Glu Ala Tyr Asp Pro Thr Thr Gln Gln Leu Pro Thr 
            580                 585                 590         


Asn Gln Met Pro His Lys Leu Gln Lys Ser Arg Lys Asp Ser Lys Val 
        595                 600                 605             


Thr Asp Thr Asp Lys Leu Leu Lys Thr Ile Asp Lys Glu Ile Asp Glu 
    610                 615                 620                 


Gly Asn Lys Lys Leu Glu Leu Ile Ala Cys His Arg Lys Glu Trp Glu 
625                 630                 635                 640 


Glu Ala Glu Gln Arg Lys Lys Ser Gly Lys Arg Asn Asn Pro Gly Thr 
                645                 650                 655     


Lys Ser Arg Lys His Leu Phe Tyr Ala Ser Glu Met Gly Glu Glu Ala 
            660                 665                 670         


Thr Trp Ile Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Pro Ala Arg 
        675                 680                 685             


Ala Glu Trp Lys Gly Thr His His Ser Glu Leu Gln Arg Leu Leu Ala 
    690                 695                 700                 


Phe Tyr Ser Thr Gln Arg Leu Glu Ala Trp Gln Leu Val Glu Ser Val 
705                 710                 715                 720 


Trp Thr Ala Asn Thr His Ser Phe Trp Glu Glu Asn Phe Lys Glu Ala 
                725                 730                 735     


Phe Tyr Lys Pro Glu Phe Glu Asn Phe Tyr Gly Ala Tyr Ile Glu Ile 
            740                 745                 750         


Arg Thr Lys Ile Leu Thr Thr Cys Arg Ser Ile Leu Glu Asn Asn Pro 
        755                 760                 765             


Glu Ala Thr Met Asn Asn Asp Thr Glu Lys Glu Trp Asp Lys Val Phe 
    770                 775                 780                 


Thr Leu Phe Asp Lys Arg Leu Tyr Arg Thr Ser Thr Thr Asp Glu Gln 
785                 790                 795                 800 


Lys Lys Gln Leu Leu Thr Lys Pro Phe Ala Phe Pro Arg Gly Leu Phe 
                805                 810                 815     


Asp Asp Lys Pro Thr Phe Leu Pro Gly Ser Lys Pro Asn Glu Asn Pro 
            820                 825                 830         


Glu Arg Phe Ala Ala Trp Tyr Ser Tyr Gly Tyr Thr Tyr Ser Gly Lys 
        835                 840                 845             


Phe Gln Ser Phe Tyr Asp Met Pro Arg Asn Tyr Ser Asp Trp Tyr Lys 
    850                 855                 860                 


Lys Leu Lys Glu Asp Gly Lys Leu Pro Arg Leu Asp Lys Lys Thr Glu 
865                 870                 875                 880 


Gln Glu Lys Ile Leu Arg Phe Arg Met Asp Cys Asp Leu Asn Ile Lys 
                885                 890                 895     


His Ile Arg Phe Gln Asp Ile Tyr Val Lys Leu Met Val Asp Ser Leu 
            900                 905                 910         


Tyr Lys Ala Val Phe Gly Gln Gln Pro Glu Phe Asp Leu Ser His Leu 
        915                 920                 925             


Tyr Asp Thr Arg Ser Glu Arg Tyr Glu Asn Asn Thr Ile Ala Gln Arg 
    930                 935                 940                 


Gln Lys Ser Arg Gln Glu Gly Asp Asn Ser Asp Asn Ala Ile Asn Glu 
945                 950                 955                 960 


Asn Tyr Val Trp Asn Lys Thr Phe Ala Ile Ser Leu Tyr Asn Gly Arg 
                965                 970                 975     


Ile Thr Glu Ser Gln Val Lys Leu Lys Asp Val Gly Lys Phe Arg Arg 
            980                 985                 990         


Phe Ala Thr Asp Pro Arg Val Gln  Thr Leu Ile Ser Tyr  Asp Asp Thr 
        995                 1000                 1005             


Arg Thr  Trp Thr Lys Leu Glu  Ile Glu Asn Glu Leu  Asp Asn Lys 
    1010                 1015                 1020             


Ala Asp  Ala Tyr Glu Pro Ile  Arg Arg Thr Gln Ser  Leu Lys Ala 
    1025                 1030                 1035             


Ile Gln  Gln Leu Glu Lys Asn  Ile Leu Lys Lys Asn  Gly Phe Asn 
    1040                 1045                 1050             


Gly Lys  Gln His Pro Glu Glu  Leu Lys His Asn Gly  Asn Pro Asn 
    1055                 1060                 1065             


Phe Arg  Lys Tyr Ile Ala Asn  Gly Leu Leu Lys His  Arg Thr Asp 
    1070                 1075                 1080             


Ile Arg  Gln Glu Glu Leu Ala  Leu Ile Ser Asp Thr  Glu Phe Gln 
    1085                 1090                 1095             


Glu Ile  Gly Leu Glu Arg Ile  Arg Gln Thr Asn Pro  Leu Ile Gln 
    1100                 1105                 1110             


Lys Ala  Tyr Leu Leu Ile Leu  Leu Arg Asn Lys Phe  Gly His Asn 
    1115                 1120                 1125             


Gln Leu  Pro Asp Gln Glu His  Phe Arg Leu Met Arg  Ser Ile Tyr 
    1130                 1135                 1140             


Pro Tyr  Asn Gln Gln Glu Ser  Tyr Ser Ala Tyr Phe  Asn His Val 
    1145                 1150                 1155             


Ile Thr  Gln Ile Ile Glu Glu  Leu Asn Thr 
    1160                 1165             


<210>  1375
<211>  1140
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1375

Met Glu Asn Asp Gln Gln Ile Leu Glu Asn Arg Arg Arg Thr Leu Ala 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Ser Asn His Leu Ala Thr Ser Phe Glu Gln Lys Ala 
        35                  40                  45              


Leu His Glu Glu Gly Gln Ile Pro Ala Ser Phe Leu Cys Asn Lys Ser 
    50                  55                  60                  


Ile Lys Lys Ile Asn Trp Asn His Val Tyr Ser Lys Ala Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Ile Phe Asp Ala Asp Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Arg Glu Thr Ser Asp Lys Glu Gly Lys Asp Phe Thr Ala Met Asn Glu 
            100                 105                 110         


Thr Leu Lys Leu Val Phe Asp Glu Leu Gln Ala Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Ala Asp Ser Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Val Glu Leu Ala Asp Phe Leu Thr Val Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Ala Asp Asp Asp Tyr 
                165                 170                 175     


Ala Val Val Glu Ser Lys Gln Ile Val Thr Pro Asp Asn Gln Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Ile Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Val Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Leu Ala Tyr Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asp Leu Arg Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Glu 
            260                 265                 270         


Val Ile Thr Glu Glu Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Glu Glu Glu Arg 
    290                 295                 300                 


Glu Lys Ile Leu Asp Glu Ile Asp Tyr Glu Asp Tyr Ile Glu Ser Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg His Ser Asn Arg Phe Pro Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Glu Lys Tyr Asn Lys Gln Phe Asp Gly Glu 
        355                 360                 365             


Ala Thr Glu Arg Lys Val Val Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asn Gln Glu Thr Val Glu Leu Lys Ile Asp Ser Ala 
385                 390                 395                 400 


Gln Arg Thr Asn Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Glu Ala Arg Leu Leu 
            420                 425                 430         


Thr Lys Ala Lys Pro Glu Ser Lys Val Ser Tyr Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Lys Ala Glu Glu Met Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Lys Val Asn Asp Ser Gln Leu Met Asn Met Gln Phe Ile Asp Glu 
                485                 490                 495     


Ile Lys Glu Gln Leu Pro Ala Asp Trp Asn Glu Phe Gly Lys Arg Ser 
            500                 505                 510         


Asp Ser Lys Lys Lys Lys Ala Tyr Thr Asn Ala Ala Arg Gln Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Lys Val Leu Ala Asn Tyr Gln Leu 
    530                 535                 540                 


Asn Asp Lys Gln Val Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Val 
545                 550                 555                 560 


Lys Glu Val Asp Asp Ser Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Met Glu Lys His Lys Val 
            580                 585                 590         


Asp Lys Ser Ala Arg Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Thr Asp Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Tyr 
625                 630                 635                 640 


Ala Asp Asn Glu Lys Lys Ala Thr Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Lys Asp Gly His Pro Phe Leu Ala Asn Ile Asn 
            660                 665                 670         


Leu Arg Gln Ile Arg Lys Thr Ser Gln Leu Tyr Glu Leu Tyr Leu Val 
        675                 680                 685             


Glu Lys Ala Asn Lys Gln Val Lys Lys Met Asn Pro Lys Thr Gln Arg 
    690                 695                 700                 


Thr Asn Asn Val Asp Glu Ser Trp Met Met Lys Ser Phe Tyr Ala Lys 
705                 710                 715                 720 


Glu Trp Asn Glu Glu Met Gly Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Thr Asn Ile Pro Phe Thr Ile Arg Gln Trp Glu Glu Lys 
            740                 745                 750         


Glu Lys His Asn Leu Gln Ala Trp Leu His Asn Ile Thr Lys Gly Lys 
        755                 760                 765             


Thr Ser Lys Asp Gly Lys Lys Ala Val Asp Leu Pro Thr Asn Leu Phe 
    770                 775                 780                 


Asp Asp Thr Leu Cys Glu Leu Leu Arg Glu Ala Leu Ile Asn Glu Gly 
785                 790                 795                 800 


Ile Asp Ala Thr Pro Thr Thr Lys Tyr Asn Glu Leu Leu Lys His Trp 
                805                 810                 815     


Trp Thr Ala Arg Glu Asp Ser Thr Gln Asp Phe Tyr Leu Ser Glu Arg 
            820                 825                 830         


Gln Tyr Asp Ile Tyr Asp Glu Lys Val Cys Phe Thr Ile Asn Ser Ser 
        835                 840                 845             


Ala His Phe Ala Asp Tyr Tyr Ala Pro Ala Leu Ser Lys Ala Tyr Ser 
    850                 855                 860                 


Arg Leu Arg Ala Glu Arg Asp Val Ala Arg Arg Thr Asp Lys Arg Leu 
865                 870                 875                 880 


Pro Pro Val Glu Arg Lys Asp Val Glu Arg Val Phe Lys Asn Thr Ile 
                885                 890                 895     


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
            900                 905                 910         


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asn Gln Gln Gln Leu Lys 
        915                 920                 925             


Leu Ser Lys Met Asp Ser Leu Leu Asn Glu Thr Lys Arg Ile Glu Gln 
    930                 935                 940                 


Val Ile Asn Thr Gln Leu Ser Phe Asp Gln Lys Gly Lys Glu Ile Lys 
945                 950                 955                 960 


Asp Lys Thr Asn Leu Glu Ile Val Lys Thr Ile Val Ala Glu Arg Lys 
                965                 970                 975     


Gln Lys Asn Tyr Thr Glu Met Arg Lys Tyr Val His Asp Arg Arg Leu 
            980                 985                 990         


Pro Glu Leu Phe Glu Tyr Ile Asp  Gly Asn Glu Leu Pro  Leu Asp Met 
        995                 1000                 1005             


Leu Leu  Asn Glu Leu Arg Ala  Tyr Asn Thr Ala Lys  Gln Val Val 
    1010                 1015                 1020             


Phe Asp  Thr Val Phe Ala Leu  Glu Lys Lys Ile Ile  Glu Thr Asp 
    1025                 1030                 1035             


Pro Glu  Gly Leu Lys Gln Leu  Asn Val Ser Lys Asp  Gly Gln Ile 
    1040                 1045                 1050             


Gln Thr  Gly Asn Ile Gln His  Lys Pro Tyr Val Gln  Trp Leu Glu 
    1055                 1060                 1065             


Asn Lys  Gly Leu Ile Thr Asp  Lys Asp Lys Gln Phe  Ile Asn Met 
    1070                 1075                 1080             


Val Arg  Asn Ser Phe Ser His  Asn Gln Phe Pro Gln  Arg Ser Thr 
    1085                 1090                 1095             


Val Glu  Leu Leu Met Pro Val  Trp Gln Asn Thr Asn  Ile Ala Leu 
    1100                 1105                 1110             


Gln Ile  Ala Arg Glu Tyr Gln  Gln Leu Ile Val Asp  Ile Ile Glu 
    1115                 1120                 1125             


Lys Ser  Leu His Pro His Lys  Gln His Gln Met Val  
    1130                 1135                 1140 


<210>  1376
<211>  1057
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1376

Met Thr Ile Lys Glu Gln Ser His Phe Ala Ala Tyr Tyr Asn Met Ala 
1               5                   10                  15      


Arg His Asn Met Tyr Glu Thr Leu Cys Tyr Ile Ser Lys Ile Ser Gly 
            20                  25                  30          


Ile Gln Glu Gly Glu Asp Asn Lys Glu Ser Lys Ile Glu Asp Met Gln 
        35                  40                  45              


Leu Leu Arg Val Leu Thr Thr Lys Gly His Pro Glu Glu Lys Ile Arg 
    50                  55                  60                  


Ile Glu Lys Leu Ile Tyr Lys His Leu Pro Leu Phe Arg Pro Ala Val 
65                  70                  75                  80  


Glu Asp Leu Arg Lys Lys Ser Lys Glu Asn Val Lys Ser Pro Glu Leu 
                85                  90                  95      


Leu Ala Lys Val Ile Lys Asn Trp Ala Lys Val Ile Thr Tyr Tyr Arg 
            100                 105                 110         


Asp Lys Phe Thr His Tyr Val Phe Ile Asp Lys Arg His Glu Asn Lys 
        115                 120                 125             


Glu Phe Leu Asn Ala Glu Met Ser Val Ala Asn Asp Leu Asn Gln Ile 
    130                 135                 140                 


Phe Thr Ala Ser Ala Arg Val Ile Lys Glu Arg Phe Gly Leu Ser Thr 
145                 150                 155                 160 


Glu Leu Glu Phe Leu Thr Lys Gly Arg Tyr Arg Thr Gln Thr Ile Asp 
                165                 170                 175     


Gly Lys Arg Ser Thr Lys Leu Asn Pro Asn Phe Ile Tyr Ser Leu Gln 
            180                 185                 190         


Asp Lys Asn Glu Arg Leu Asn Lys Met Gly Leu Ile Phe Leu Ala Cys 
        195                 200                 205             


Gln Leu Ile Glu Lys Lys Tyr Ala Ser Met Leu Phe Asp Gln Gln Gly 
    210                 215                 220                 


Tyr Met Gly Arg Asp Ile Tyr Phe Asp Phe Thr Pro Ala Gln Cys Lys 
225                 230                 235                 240 


Tyr Ile Arg Glu Val Phe Ser Ala His Arg Ile Val Leu Pro Arg Gly 
                245                 250                 255     


Arg Met Asp Val Glu Arg Asn Glu Ile Thr Ile Ala Met Asp Met Phe 
            260                 265                 270         


Asn Glu Leu Gly Lys Cys Pro Lys Glu Leu Phe Glu Ile Ile Ser Lys 
        275                 280                 285             


Glu Glu Gln Lys Arg Phe Arg Thr Lys Ser Glu Thr Thr Gly Glu Glu 
    290                 295                 300                 


Val Leu Leu Met Arg His Ser Asp Arg Phe Ala Thr Leu Ala Leu Gln 
305                 310                 315                 320 


Tyr Ile Asp Asn Arg Lys Val Phe Glu Lys Ile Arg Phe Gln Leu Ser 
                325                 330                 335     


Leu Gly Lys Tyr Arg Tyr Lys Phe Tyr Asp Lys Thr Cys Val Asp Gly 
            340                 345                 350         


Asp Thr His Val Arg Ile Leu Gln Lys Glu Leu Asn Gly Phe Gly Arg 
        355                 360                 365             


Ile Asn Glu Ile Glu Leu Leu Lys Glu Glu Lys Trp Gly Gly Leu Ile 
    370                 375                 380                 


Arg Lys Phe Glu Asp Ala Lys Ile Asp Thr Ala Glu Thr Lys Pro Tyr 
385                 390                 395                 400 


Ile Thr Asp Gln Tyr Pro Gln Tyr Leu Phe Asn Gly Asn Arg Ile Gly 
                405                 410                 415     


Ile Tyr Phe Asn Ser Ala His Gly Lys Ala Met Arg Asn Gly Ala Tyr 
            420                 425                 430         


Ile Pro Asp Ile Glu Ser Gly Ala His Cys Ile Gln Pro Ile Cys Trp 
        435                 440                 445             


Ile Ser Asn Tyr Glu Leu Pro Ala Leu Ile Phe His His Ile Leu Thr 
    450                 455                 460                 


Lys Asp Glu Lys Lys Ser Leu Thr Glu Lys Ile Ile Ile Asp Cys Val 
465                 470                 475                 480 


Glu Arg Tyr Lys Lys Leu Phe Asn Asp Ile Ala Glu Gly Lys Val Ala 
                485                 490                 495     


Arg Thr Gly Asn Ala Thr Ser Asp Phe Glu Met Ile Ser Lys Glu Tyr 
            500                 505                 510         


Gly Ile Glu Lys Ser Asp Ile Pro Arg Glu Leu Gln Asp Tyr Phe Asn 
        515                 520                 525             


Gly Thr Glu Arg Asp Gly Ile Glu Gln Tyr Ala Lys Ala Gln Ile Arg 
    530                 535                 540                 


Glu Met Ile Glu Glu Asn Arg Ile Arg Leu Glu Gln Phe Asn Ser Lys 
545                 550                 555                 560 


Leu Lys Lys Ile Glu Asp Gly Glu Val Lys Tyr Gly Lys Arg Asp Tyr 
                565                 570                 575     


Thr Glu Ile Arg Thr Gly Glu Leu Ala Gln Tyr Leu Ala Lys Asp Ile 
            580                 585                 590         


Val Met Phe Met Pro Lys Ala Lys Tyr Lys Pro Thr Ser Lys Asn Tyr 
        595                 600                 605             


Asn Val Met Gln Ala Leu Leu Ala Thr Phe Asn Gly Ser Glu Ser Gly 
    610                 615                 620                 


Ser Thr Leu Asp Glu Val Asp Asp Met Phe Asp Asn Ile Lys Ala Cys 
625                 630                 635                 640 


Tyr Trp Lys Asn Glu Ser Asp Asn His Pro Phe Leu Glu Tyr Val Leu 
                645                 650                 655     


Gly Glu Glu Pro Lys Asp Ile Ile Ala Phe Tyr Lys Ile Tyr Leu Glu 
            660                 665                 670         


Leu Arg Gly Glu Tyr Leu Asp Lys Cys Ile Lys Lys Met Asp Leu Ala 
        675                 680                 685             


Thr Ile Pro Phe Ile His Thr Glu Arg Lys Arg Trp Glu Lys Arg Asp 
    690                 695                 700                 


Glu Lys Phe Phe Lys Glu Leu Ala Gln Arg Tyr Ala Thr Gln Pro Ile 
705                 710                 715                 720 


Glu Leu Pro Arg Gly Leu Tyr Asp Arg Ala Ile Lys Glu Tyr Leu Lys 
                725                 730                 735     


Ser Lys Ser Ile Leu Glu Asp Val Ile Ala Gln Glu Gln Cys Asn Val 
            740                 745                 750         


Thr Tyr Leu Ile Ala Arg Tyr Met Gln Asp Val Leu Lys Asp Asp Ser 
        755                 760                 765             


Gln Gln Phe Tyr Ser Leu Pro Arg His Tyr Ser Cys Leu Ser Glu Lys 
    770                 775                 780                 


Asp Lys Tyr Leu Ser Leu Thr Glu Arg Glu Ala Ile Ala Lys Ser Asp 
785                 790                 795                 800 


Ala Leu Asn Ser Phe Lys Lys Arg Glu Arg Glu Lys Glu Asn Glu Asn 
                805                 810                 815     


Arg Arg Gly Asn Arg Arg Tyr Asn Lys Gly Glu Asn Lys Asn Thr Ile 
            820                 825                 830         


Lys Asp Arg Asp Thr Glu Glu Lys Phe Asn Ser Leu Tyr Arg Lys Met 
        835                 840                 845             


Asp Asn Asn Glu Arg Ile Leu Arg Arg Tyr Lys Val Gln Asp Met Leu 
    850                 855                 860                 


Leu Tyr Leu Leu Ala Cys Asp Ile Ile Lys Gly Ile Met Arg Glu Asp 
865                 870                 875                 880 


Phe Gly Tyr Lys Leu Ser Met Ile Thr Asp Gly Lys Asn Ser Asn Phe 
                885                 890                 895     


Phe Asp Tyr Lys Met Pro Glu Phe Lys Thr Thr Ile Thr Leu Lys Glu 
            900                 905                 910         


Gly Lys Lys Phe Thr Ile Lys Gln Gln Tyr Leu Lys Ile Lys Asn Tyr 
        915                 920                 925             


Gly Asp Phe Leu Lys Phe Ile Phe Asp Leu Arg Ile Asp Ser Leu Leu 
    930                 935                 940                 


Ser Asn Gly Thr Lys Val Glu Ile Asp Arg Asn Ile Leu Glu Asp Glu 
945                 950                 955                 960 


Leu Ser Asn Tyr Asp Gly Ser Arg Pro Lys Val Phe Glu Thr Leu Leu 
                965                 970                 975     


Met Ile Glu Lys Ile Val Val Glu Lys His Lys Glu Leu Lys Asp Leu 
            980                 985                 990         


Glu His Ile Thr Phe Gly Asp Val  Leu Asn Val Ile Lys  Met Glu Glu 
        995                 1000                 1005             


Gly Glu  Lys Lys Ile Leu Arg  Leu Ile Arg Asn Ala  Phe Ser His 
    1010                 1015                 1020             


Asn Tyr  Tyr Pro Thr Ile Lys  Asp Val Asn Tyr Asp  Asn Met Pro 
    1025                 1030                 1035             


Glu Val  Ala Glu Ser Leu Lys  Asp Ile Leu Glu Lys  Glu Ser Lys 
    1040                 1045                 1050             


Lys Leu  Thr Asn 
    1055         


<210>  1377
<211>  1057
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1377

Met Thr Ile Lys Glu Gln Ser His Phe Ala Ala Tyr Tyr Asn Met Ala 
1               5                   10                  15      


Arg His Asn Met Tyr Glu Thr Leu Cys Tyr Ile Ser Lys Ile Ser Gly 
            20                  25                  30          


Ile Gln Glu Gly Glu Asp Asn Lys Glu Ser Lys Ile Glu Asp Met Gln 
        35                  40                  45              


Leu Leu Arg Val Leu Thr Thr Lys Gly His Pro Glu Glu Lys Ile Arg 
    50                  55                  60                  


Ile Glu Lys Leu Ile Tyr Lys His Leu Pro Leu Phe Arg Pro Ala Val 
65                  70                  75                  80  


Glu Asp Leu Arg Lys Lys Ser Lys Glu Asn Val Lys Ser Pro Glu Leu 
                85                  90                  95      


Leu Ala Lys Val Ile Lys Asn Trp Ala Lys Val Ile Thr Tyr Tyr Arg 
            100                 105                 110         


Asp Lys Phe Thr His Tyr Val Phe Ile Asp Lys Arg His Glu Asn Lys 
        115                 120                 125             


Glu Phe Leu Asn Ala Glu Met Ser Val Ala Asn Asp Leu Asn Gln Ile 
    130                 135                 140                 


Phe Thr Ala Ser Ala Arg Val Ile Lys Glu Arg Phe Gly Leu Ser Thr 
145                 150                 155                 160 


Glu Leu Glu Phe Leu Thr Lys Gly Arg Tyr Arg Thr Gln Thr Ile Asp 
                165                 170                 175     


Gly Lys Arg Ser Thr Lys Leu Asn Pro Asn Phe Ile Tyr Ser Leu Gln 
            180                 185                 190         


Asp Lys Asn Glu Arg Leu Asn Lys Met Gly Leu Ile Phe Leu Ala Cys 
        195                 200                 205             


Gln Leu Ile Glu Lys Lys Tyr Ala Ser Met Leu Phe Asp Gln Gln Gly 
    210                 215                 220                 


Tyr Met Gly Arg Asp Ile Tyr Phe Asp Phe Thr Pro Ala Gln Cys Lys 
225                 230                 235                 240 


Tyr Ile Arg Glu Val Phe Ser Ala His Arg Ile Val Leu Pro Arg Gly 
                245                 250                 255     


Arg Met Asp Val Glu Arg Asn Glu Ile Thr Ile Ala Met Asp Met Phe 
            260                 265                 270         


Asn Glu Leu Gly Lys Cys Pro Lys Glu Leu Phe Glu Ile Ile Ser Lys 
        275                 280                 285             


Glu Glu Gln Lys Arg Phe Arg Thr Lys Ser Glu Thr Thr Gly Glu Glu 
    290                 295                 300                 


Val Leu Leu Met Arg His Ser Asp Arg Phe Ala Thr Leu Ala Leu Gln 
305                 310                 315                 320 


Tyr Ile Asp Asn Arg Lys Val Phe Glu Lys Ile Arg Phe Gln Leu Ser 
                325                 330                 335     


Leu Gly Lys Tyr Arg Tyr Lys Phe Tyr Asp Lys Thr Cys Val Asp Gly 
            340                 345                 350         


Asp Thr His Val Arg Ile Leu Gln Lys Glu Leu Asn Gly Phe Gly Arg 
        355                 360                 365             


Ile Asn Glu Ile Glu Leu Leu Lys Glu Glu Lys Trp Gly Gly Leu Ile 
    370                 375                 380                 


Arg Lys Phe Glu Asp Ala Lys Ile Asp Thr Ala Glu Thr Lys Pro Tyr 
385                 390                 395                 400 


Ile Thr Asp Gln Tyr Pro Gln Tyr Leu Phe Asn Gly Asn Arg Ile Gly 
                405                 410                 415     


Ile Tyr Phe Asn Ser Ala His Gly Lys Ala Met Arg Asn Gly Ala Tyr 
            420                 425                 430         


Ile Pro Asp Ile Glu Ser Gly Ala His Cys Ile Gln Pro Ile Cys Trp 
        435                 440                 445             


Ile Ser Asn Tyr Glu Leu Pro Ala Leu Ile Phe His His Ile Leu Thr 
    450                 455                 460                 


Lys Asp Glu Lys Lys Ser Leu Thr Glu Lys Ile Ile Ile Asp Cys Val 
465                 470                 475                 480 


Glu Arg Tyr Lys Lys Leu Phe Asn Asp Ile Ala Glu Gly Lys Val Ala 
                485                 490                 495     


Arg Thr Gly Asn Ala Thr Ser Asp Phe Glu Met Ile Ser Lys Glu Tyr 
            500                 505                 510         


Gly Ile Glu Lys Ser Asp Ile Pro Arg Glu Leu Gln Asp Tyr Phe Asn 
        515                 520                 525             


Gly Thr Glu Arg Asp Gly Ile Glu Gln Tyr Ala Lys Ala Gln Ile Arg 
    530                 535                 540                 


Glu Met Ile Glu Glu Asn Arg Ile Arg Leu Glu Gln Phe Asn Ser Lys 
545                 550                 555                 560 


Leu Lys Lys Ile Glu Asp Gly Glu Val Lys Tyr Gly Lys Arg Asp Tyr 
                565                 570                 575     


Thr Glu Ile Arg Thr Gly Glu Leu Ala Gln Tyr Leu Ala Lys Asp Ile 
            580                 585                 590         


Val Met Phe Met Pro Lys Ala Lys Tyr Lys Pro Thr Ser Lys Asn Tyr 
        595                 600                 605             


Asn Val Met Gln Ala Leu Leu Ala Thr Phe Asn Gly Ser Glu Ser Gly 
    610                 615                 620                 


Ser Thr Leu Asp Glu Val Asp Asp Met Phe Asp Asn Ile Lys Ala Cys 
625                 630                 635                 640 


Tyr Trp Lys Asn Glu Ser Asp Asn His Pro Phe Leu Glu Tyr Val Leu 
                645                 650                 655     


Gly Glu Glu Pro Lys Asp Ile Ile Ala Phe Tyr Lys Ile Tyr Leu Glu 
            660                 665                 670         


Leu Arg Gly Glu Tyr Leu Asp Lys Cys Ile Lys Lys Met Asp Leu Ala 
        675                 680                 685             


Thr Ile Pro Phe Ile His Thr Glu Arg Lys Arg Trp Glu Lys Arg Asp 
    690                 695                 700                 


Glu Lys Phe Phe Lys Glu Leu Ala Gln Arg Tyr Ala Thr Gln Pro Ile 
705                 710                 715                 720 


Glu Leu Pro Arg Gly Leu Tyr Asp Arg Ala Ile Lys Glu Tyr Leu Lys 
                725                 730                 735     


Ser Lys Ser Ile Leu Glu Asp Val Ile Ala Gln Glu Gln Cys Asn Val 
            740                 745                 750         


Thr Tyr Leu Ile Ala Arg Tyr Met Gln Asp Val Leu Lys Asp Asp Ser 
        755                 760                 765             


Gln Gln Phe Tyr Ser Leu Pro Arg His Tyr Ser Cys Leu Ser Glu Lys 
    770                 775                 780                 


Asp Lys Tyr Leu Ser Leu Thr Glu Arg Glu Ala Ile Ala Lys Ser Asp 
785                 790                 795                 800 


Ala Leu Asn Ser Phe Lys Lys Arg Glu Arg Glu Lys Glu Asn Glu Asn 
                805                 810                 815     


Arg Arg Gly Asn Arg Arg Tyr Asn Lys Gly Glu Asn Lys Asn Thr Ile 
            820                 825                 830         


Lys Asp Arg Asp Thr Glu Glu Lys Phe Asn Ser Leu Tyr Arg Lys Met 
        835                 840                 845             


Asp Asn Asn Glu Arg Ile Leu Arg Arg Tyr Lys Val Gln Asp Met Leu 
    850                 855                 860                 


Leu Tyr Leu Leu Ala Cys Asp Ile Ile Lys Gly Ile Met Arg Glu Asp 
865                 870                 875                 880 


Phe Gly Tyr Lys Leu Ser Met Ile Thr Asp Gly Lys Asn Ser Asn Phe 
                885                 890                 895     


Phe Asp Tyr Lys Met Pro Glu Phe Lys Thr Thr Ile Thr Leu Lys Glu 
            900                 905                 910         


Gly Lys Lys Phe Thr Ile Lys Gln Gln Tyr Leu Lys Ile Lys Asn Tyr 
        915                 920                 925             


Gly Asp Phe Leu Lys Phe Ile Phe Asp Leu Arg Ile Asp Ser Leu Leu 
    930                 935                 940                 


Ser Asn Gly Thr Lys Val Glu Ile Asp Arg Asn Ile Leu Glu Asp Glu 
945                 950                 955                 960 


Leu Ser Asn Tyr Asp Gly Ser Arg Pro Lys Val Phe Glu Thr Leu Leu 
                965                 970                 975     


Met Ile Glu Lys Ile Val Val Glu Lys His Lys Glu Leu Lys Asp Leu 
            980                 985                 990         


Glu His Ile Thr Phe Gly Asp Val  Leu Asn Val Ile Lys  Met Glu Glu 
        995                 1000                 1005             


Gly Glu  Lys Lys Ile Leu Arg  Leu Ile Arg Asn Ala  Phe Ser His 
    1010                 1015                 1020             


Asn Tyr  Tyr Pro Thr Ile Lys  Asp Val Asn Tyr Asp  Asn Met Pro 
    1025                 1030                 1035             


Glu Val  Ala Glu Ser Leu Lys  Asp Ile Leu Glu Lys  Glu Ser Lys 
    1040                 1045                 1050             


Lys Leu  Thr Asn 
    1055         


<210>  1378
<211>  1081
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1378

Met Gln Ala Gln Ser Leu Phe Asp Glu Tyr Lys His Leu Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Val Met Ser Ile Met Asn Ile Ile Thr Val Leu Asn His Ile 
            20                  25                  30          


His Gln Ile Ala Gly Leu Lys Arg Asn Glu Leu Gly Asp Asp Asp Asn 
        35                  40                  45              


Ile Tyr Ser His Pro Val Leu Lys Tyr Ile Ala Pro Glu Asn Asn Ser 
    50                  55                  60                  


Thr Thr Leu Pro Glu Lys Arg Asp Leu Ile Lys Glu Leu Leu Leu Glu 
65                  70                  75                  80  


Tyr Leu Pro Phe Leu Glu Ala Met Lys Asp Cys Tyr Lys Glu Val Lys 
                85                  90                  95      


Val Glu Lys Asp Lys Arg Asn Asn Lys Tyr Val Lys Asp Lys Lys Gln 
            100                 105                 110         


Val Phe Ile Arg Asn Tyr Ser Asp Ile Tyr Cys Ile Tyr Trp Thr Leu 
        115                 120                 125             


Tyr Asn Ile Phe Ser Thr Leu Ile Asn Tyr Arg Asp Lys Ser Cys His 
    130                 135                 140                 


Tyr Arg Phe Ile Pro Ser Lys Asp Gln Glu Glu Tyr Ser Lys Arg Thr 
145                 150                 155                 160 


Glu Tyr Asp Thr Val Arg Ile Ile Asn Lys Tyr Tyr Thr Tyr Ala Leu 
                165                 170                 175     


Arg Lys Thr Lys Glu Lys Tyr Gly Tyr Thr Thr Glu Gln Leu Ser Phe 
            180                 185                 190         


Ile Gln Asn Asn Arg Tyr Thr Asp Asp Lys Lys Val Asn Phe Asn Phe 
        195                 200                 205             


Phe Leu Ser Met Gln Ser Ser Asn Asn Asn Leu Ser His Val Gly Val 
    210                 215                 220                 


Ala Gln Leu Ile Cys Leu Phe Leu Gln Lys Lys Asp Val Asp Asn Phe 
225                 230                 235                 240 


Leu Glu Asn Leu Pro Ile Tyr Asp Asn Arg Tyr Cys Leu Gly Ile Asp 
                245                 250                 255     


Glu His Met Ile Ile Lys Arg Ser Leu Ala Leu His Ser Ile Lys Leu 
            260                 265                 270         


Pro Lys Glu Arg Leu Asn Ser Glu Lys Lys Asp Met Ala Ile Ala Met 
        275                 280                 285             


Asp Met Leu Asn Glu Leu Lys Arg Cys Pro Lys Glu Leu Phe Asn Thr 
    290                 295                 300                 


Leu Pro Phe Asp Lys Gln Glu Arg Phe Arg Ile Ile Ser Ser Asp His 
305                 310                 315                 320 


Lys Glu Val Leu Leu Met Arg Ser Thr Asp Arg Phe Val Pro Leu Ile 
                325                 330                 335     


Leu Gln Tyr Ile Asp Cys Asn Lys Lys Phe Lys Asp Ile Arg Phe His 
            340                 345                 350         


Val Asn Met Gly Lys Leu Arg Tyr Leu Phe Ser Pro Asn Lys Leu Cys 
        355                 360                 365             


Ile Asp Asn Gln Glu Arg Val Arg Met Leu Glu His Leu Leu Asn Gly 
    370                 375                 380                 


Tyr Gly Arg Ile Asp Glu Val Glu Tyr Leu Arg Lys Ala Pro Asn Gly 
385                 390                 395                 400 


Thr Phe Gly Asn Thr Asn Ile Pro Ile Lys Gly Phe Gly Glu Ile Glu 
                405                 410                 415     


Arg Asp Ser Ala Asp Ser Asn Asn Tyr Pro Tyr Ile Val Asp Thr His 
            420                 425                 430         


Thr His Tyr Ile Leu Asn Asn Asn Lys Val Glu Phe Cys Phe Cys Glu 
        435                 440                 445             


Asp Ser Lys Asn Lys Asn Val Phe Pro Thr Ile Glu Lys Glu Ile Asn 
    450                 455                 460                 


Gly Lys Trp Tyr Val Glu Lys Thr Ala Pro His Cys Arg Ile Ser Phe 
465                 470                 475                 480 


Phe Glu Ile Pro Ala Met Ala Phe His Met Phe Leu Cys Gly Ser Glu 
                485                 490                 495     


Lys Thr Glu Lys Leu Ile Lys Asp Val Tyr Asn Asn Tyr Ile Ser Leu 
            500                 505                 510         


Phe Asn Ala Leu Lys Asn Gly Ala Leu Thr Glu Glu Asn Tyr Lys Asp 
        515                 520                 525             


Phe Asn Ile Pro Glu Cys Asp Met Pro Lys Lys Ile Leu Asp Phe Leu 
    530                 535                 540                 


Lys Gly Lys Ala Glu Gly Lys Ser Ile Asp Gly Tyr Val Lys Asn Ile 
545                 550                 555                 560 


Leu Lys Lys Glu Leu Lys Asp Thr Arg Lys Arg Ile Glu Gln Ala Pro 
                565                 570                 575     


Ser Glu Lys Asp Gln Met Pro Ser Lys Arg Asn Lys Ile Gly Thr Lys 
            580                 585                 590         


Ser Tyr Lys Arg Val Leu Thr Gly Lys Leu Ala Asp Phe Leu Ala Lys 
        595                 600                 605             


Asp Ile Val Lys Tyr Gln Pro Thr Leu Cys Ala Gly Asp Asp Tyr Gly 
    610                 615                 620                 


Ile Asp Arg Met Thr Gly Met Asn Tyr Arg Ile Met Gln Ala Thr Ile 
625                 630                 635                 640 


Ala Thr Tyr Asn Asp Asp Asp Asp Phe Asp Thr Phe Tyr Asn Val Phe 
                645                 650                 655     


Lys Met Ala Gly Leu Val Asp Gly Asp Glu Arg Lys Asn His Pro Phe 
            660                 665                 670         


Leu Lys Lys Val Leu Leu Ser Lys Pro Gln Asn Thr Val Ala Phe Asn 
        675                 680                 685             


Ile Lys Tyr Leu Lys Glu Lys Glu Ile Tyr Leu Arg Asn Ile Glu Lys 
    690                 695                 700                 


Lys Asn Ile Ile Pro Pro Phe Val Asn Arg Glu Arg Asn Lys Trp Cys 
705                 710                 715                 720 


Glu Arg Asp Cys Glu Tyr Tyr Arg Ile Leu Gly Glu Asn Leu Leu Asp 
                725                 730                 735     


Leu Pro Ile Glu Leu Pro Arg Gln Met Phe Tyr Lys Asp Ile Arg Ala 
            740                 745                 750         


Gln Leu Glu Pro Leu Met Pro Glu Ile Asp Phe Ser Gln Thr Asn Thr 
        755                 760                 765             


Thr Tyr Leu Ile Ala Glu Tyr Leu Lys Arg Val Arg Gly Asp Asp Phe 
    770                 775                 780                 


Gln Glu Phe Tyr Ser Trp Glu Arg Asn Tyr Arg Tyr Ile Asp Phe Leu 
785                 790                 795                 800 


Lys Cys Ile Arg Asp Asp Asn Gly Arg Ile Cys Ala Gln Tyr Thr Thr 
                805                 810                 815     


Thr Glu Glu Arg Glu Ser Leu Trp Glu Asp Ser Lys Asn Arg Thr Ala 
            820                 825                 830         


Glu Tyr Lys Arg Ser Glu Glu Gln Lys Asn Glu Lys Lys Asp Lys Asn 
        835                 840                 845             


Phe Glu Asp Ser Leu Glu Glu Arg Ile Ser Ser Ser His Ile Lys Phe 
    850                 855                 860                 


Gln Asn Thr Glu Lys His Ile Arg Arg Tyr Lys Val Gln Asp Ala Leu 
865                 870                 875                 880 


Leu Phe Met Ile Ala Glu Lys Gln Phe Gly Lys Tyr Leu Asp Asp Ile 
                885                 890                 895     


Lys Ala Lys Asn Phe Lys Leu Lys Asp Ile Met Pro Asp Thr Asp Lys 
            900                 905                 910         


Gly Ile Leu Ser Glu Thr Met Pro Ile Asp Phe Thr Phe Thr Lys Lys 
        915                 920                 925             


Asn Ile Lys Tyr Asn Ile His Ala Lys Asn Leu Lys Phe Lys Glu Tyr 
    930                 935                 940                 


Gly Asp Leu Phe Ile Leu Ala Asn Asp Lys Arg Leu Glu Ser Leu Trp 
945                 950                 955                 960 


Lys Ile Leu Ala Thr Asp Thr Val Asn Lys Glu Glu Ile Ser Glu Glu 
                965                 970                 975     


Phe Ala Lys Tyr Asp Phe Cys Arg Pro Asp Ile Thr Lys Leu Val Leu 
            980                 985                 990         


Asp Phe Glu Lys Asp Val Leu Glu  Lys Tyr Pro Glu Ile  Ile Glu Glu 
        995                 1000                 1005             


Ala Glu  Lys Glu Tyr Lys Lys  Phe Asp Phe Lys Phe  Ile Leu Asp 
    1010                 1015                 1020             


Trp Leu  Ile Asn Lys Lys Lys  Leu Asn Tyr Gly Ile  Arg Asn Lys 
    1025                 1030                 1035             


Leu Leu  Leu Ile Arg Asn Ala  Phe Asn His Asn Ser  Tyr Pro Asp 
    1040                 1045                 1050             


Lys Lys  Tyr Ala Glu Val Arg  Glu Leu Pro Glu Ile  Ala Thr Asn 
    1055                 1060                 1065             


Leu Lys  Lys Thr Phe Asp Glu  Asn Ala Lys Lys Tyr  Glu 
    1070                 1075                 1080     


<210>  1379
<211>  1140
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1379

Met Glu Asn Asp Gln Gln Ile Leu Glu Asn Arg Arg Arg Thr Leu Ala 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Ser Asn His Leu Ala Thr Ser Phe Glu Gln Lys Ala 
        35                  40                  45              


Leu His Glu Glu Gly Gln Ile Pro Ala Ser Phe Leu Cys Asn Lys Ser 
    50                  55                  60                  


Ile Lys Lys Ile Asn Trp Asn His Val Tyr Ser Lys Ala Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Ile Phe Asp Ala Asp Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Arg Glu Thr Ser Asp Lys Glu Gly Lys Asp Phe Thr Ala Met Asn Glu 
            100                 105                 110         


Thr Leu Lys Leu Val Phe Asp Glu Leu Gln Ala Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Ala Asp Ser Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Val Glu Leu Ala Asp Phe Leu Thr Val Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Ala Asp Asp Asp Tyr 
                165                 170                 175     


Ala Val Val Glu Ser Lys Gln Ile Val Thr Pro Asp Asn Gln Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Ile Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Val Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Leu Ala Tyr Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asp Leu Arg Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Glu 
            260                 265                 270         


Val Ile Thr Glu Glu Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Glu Glu Glu Arg 
    290                 295                 300                 


Glu Lys Ile Leu Asp Glu Ile Asp Tyr Glu Asp Tyr Ile Glu Ser Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg His Ser Asn Arg Phe Pro Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Glu Lys Tyr Asn Lys Gln Phe Asp Gly Glu 
        355                 360                 365             


Ala Thr Glu Arg Lys Val Val Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asn Gln Glu Thr Val Glu Leu Lys Ile Asp Ser Ala 
385                 390                 395                 400 


Gln Arg Thr Asn Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Glu Ala Arg Leu Leu 
            420                 425                 430         


Thr Lys Ala Lys Pro Glu Ser Lys Val Ser Tyr Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Lys Ala Glu Glu Met Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Lys Val Asn Asp Ser Gln Leu Met Asn Met Gln Phe Ile Asp Glu 
                485                 490                 495     


Ile Lys Glu Gln Leu Pro Ala Asp Trp Asn Glu Phe Gly Lys Arg Ser 
            500                 505                 510         


Asp Ser Lys Lys Lys Lys Ala Tyr Thr Asn Ala Ala Arg Gln Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Lys Val Leu Ala Asn Tyr Gln Leu 
    530                 535                 540                 


Asn Asp Lys Gln Val Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Val 
545                 550                 555                 560 


Lys Glu Val Asp Asp Ser Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Met Glu Lys His Lys Val 
            580                 585                 590         


Asp Lys Ser Ala Arg Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Thr Asp Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Tyr 
625                 630                 635                 640 


Ala Asp Asn Glu Lys Lys Ala Thr Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Lys Asp Gly His Pro Phe Leu Ala Asn Ile Asn 
            660                 665                 670         


Leu Arg Gln Ile Arg Lys Thr Ser Gln Leu Tyr Glu Leu Tyr Leu Val 
        675                 680                 685             


Glu Lys Ala Asn Lys Gln Val Lys Lys Met Asn Pro Lys Thr Gln Arg 
    690                 695                 700                 


Thr Asn Asn Val Asp Glu Ser Trp Met Met Lys Ser Phe Tyr Ala Lys 
705                 710                 715                 720 


Glu Trp Asn Glu Glu Met Gly Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Thr Asn Ile Pro Phe Thr Ile Arg Gln Trp Glu Glu Lys 
            740                 745                 750         


Glu Lys His Asn Leu Gln Ala Trp Leu His Asn Ile Thr Lys Gly Lys 
        755                 760                 765             


Thr Ser Lys Asp Gly Lys Lys Ala Val Asp Leu Pro Thr Asn Leu Phe 
    770                 775                 780                 


Asp Asp Thr Leu Cys Glu Leu Leu Arg Glu Ala Leu Ile Asn Glu Gly 
785                 790                 795                 800 


Ile Asp Ala Thr Pro Thr Thr Lys Tyr Asn Glu Leu Leu Lys His Trp 
                805                 810                 815     


Trp Thr Ala Arg Glu Asp Ser Thr Gln Asp Phe Tyr Leu Ser Glu Arg 
            820                 825                 830         


Gln Tyr Asp Ile Tyr Asp Glu Lys Val Cys Phe Thr Ile Asn Ser Ser 
        835                 840                 845             


Ala His Phe Ala Asp Tyr Tyr Ala Pro Ala Leu Ser Lys Ala Tyr Ser 
    850                 855                 860                 


Arg Leu Arg Ala Glu Arg Asp Val Ala Arg Arg Thr Asp Lys Arg Leu 
865                 870                 875                 880 


Pro Pro Val Glu Arg Lys Asp Val Glu Arg Val Phe Lys Asn Thr Ile 
                885                 890                 895     


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
            900                 905                 910         


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asn Gln Gln Gln Leu Lys 
        915                 920                 925             


Leu Ser Lys Met Asp Ser Leu Leu Asn Glu Thr Lys Arg Ile Glu Gln 
    930                 935                 940                 


Val Ile Asn Thr Gln Leu Ser Phe Asp Gln Lys Gly Lys Glu Ile Lys 
945                 950                 955                 960 


Asp Lys Thr Asn Leu Glu Ile Val Lys Thr Ile Val Ala Glu Arg Lys 
                965                 970                 975     


Gln Lys Asn Tyr Thr Glu Met Arg Lys Tyr Val His Asp Arg Arg Leu 
            980                 985                 990         


Pro Glu Leu Phe Glu Tyr Ile Asp  Gly Asn Glu Leu Pro  Leu Asp Met 
        995                 1000                 1005             


Leu Leu  Asn Glu Leu Arg Ala  Tyr Asn Thr Ala Lys  Gln Val Val 
    1010                 1015                 1020             


Phe Asp  Thr Val Phe Ala Leu  Glu Lys Lys Ile Ile  Glu Thr Asp 
    1025                 1030                 1035             


Pro Glu  Gly Leu Lys Gln Leu  Asn Val Ser Lys Asp  Gly Gln Ile 
    1040                 1045                 1050             


Gln Thr  Gly Asn Ile Gln His  Lys Pro Tyr Val Gln  Trp Leu Glu 
    1055                 1060                 1065             


Asn Lys  Gly Leu Ile Thr Asp  Lys Asp Lys Gln Phe  Ile Asn Met 
    1070                 1075                 1080             


Val Arg  Asn Ser Phe Ser His  Asn Gln Phe Pro Gln  Arg Ser Thr 
    1085                 1090                 1095             


Val Glu  Leu Leu Met Pro Val  Trp Gln Asn Thr Asn  Ile Ala Leu 
    1100                 1105                 1110             


Gln Ile  Ala Arg Glu Tyr Gln  Gln Leu Ile Val Asp  Ile Ile Glu 
    1115                 1120                 1125             


Lys Ser  Leu His Pro His Lys  Gln His Gln Met Val  
    1130                 1135                 1140 


<210>  1380
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1380

Met Glu Thr Lys Gln Gln Val Gly Lys Gly Ile Ser Tyr Asp His Arg 
1               5                   10                  15      


Arg Pro Asp Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asp Gly Val Ile Gln Glu Phe Ala Met Arg Leu Asn Arg 
        35                  40                  45              


Glu Tyr Asp Pro Glu Asn Lys Asn Gln Ser Leu Phe Ser Tyr Phe Asn 
    50                  55                  60                  


Ile Asn Ala Ser Phe Thr Asp Trp Glu Arg Gly Val Asn Ile Leu Lys 
65                  70                  75                  80  


Glu Tyr Trp Pro Met Met Glu Phe Ile Asp Arg Pro Ala Thr Asp Lys 
                85                  90                  95      


Gln Phe Glu Ala Glu Lys Pro Glu Asn Arg Glu Ala Ala Lys Arg Lys 
            100                 105                 110         


Tyr Phe Leu Ala Thr Leu Gly Ala Leu Leu Thr Ser Ile Lys Asp Leu 
        115                 120                 125             


Arg His Tyr Tyr Thr His Tyr Tyr His Pro Pro Val His Leu Asn Asp 
    130                 135                 140                 


Asp Leu Phe Leu Phe Leu Asp His Ala Leu Leu Tyr Thr Ala Phe Asp 
145                 150                 155                 160 


Val Lys Lys Thr Lys Met Lys Asp Asp Lys Thr Arg Gln Leu Leu Asn 
                165                 170                 175     


Gln Asn Leu Ser Leu Glu Leu Glu Lys Leu Lys Lys Leu Lys Val Glu 
            180                 185                 190         


Glu Leu Lys Lys Lys Lys Glu Lys Gly Ile Lys Val Asn Leu Gln Asp 
        195                 200                 205             


Glu Lys Gly Ile Leu Asn Ala Ile Tyr Asn Asp Ala Phe Ala His Ile 
    210                 215                 220                 


Ile Thr Lys Glu Lys Asp Ser Asp Lys Asp Lys Leu Glu Thr Arg Tyr 
225                 230                 235                 240 


Lys Ser Ile Leu Pro Gln Asp Glu Ala Ala Glu Thr Gly Ile Asn Ile 
                245                 250                 255     


Ser Ile Ser Gly Leu Ile Phe Leu Leu Ser Leu Phe Leu Ser Arg Lys 
            260                 265                 270         


Glu Ile Glu Gln Leu Lys Ser Asn Ile Glu Gly Tyr Lys Gly Lys Val 
        275                 280                 285             


Leu Asn Ile Glu Thr Glu Val Asp Arg Lys His Asn Ser Leu Lys Tyr 
    290                 295                 300                 


Met Ala Thr His Trp Val Phe Ser Ile Leu Ala Phe Lys Gly Leu Lys 
305                 310                 315                 320 


Gln Arg Leu Thr Asn Ser Phe Glu Lys Glu Ser Leu Leu Ile Gln Met 
                325                 330                 335     


Met Asp Glu Leu Asn Lys Val Pro Asp Glu Leu Tyr Gln Thr Leu Ser 
            340                 345                 350         


Glu Thr Ala Lys Lys Glu Phe Leu Glu Asp Ile Asn Glu Tyr Val Ser 
        355                 360                 365             


Glu Gly Asp Asp Asn Glu Lys Ala Thr Tyr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Ser Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gln Phe Pro Thr Leu Lys Phe Gln Ile Phe Val Gly 
                405                 410                 415     


Gln Tyr Leu His Asp Asn Arg Pro Lys Thr Leu Ala Ser Asn Gly Met 
            420                 425                 430         


Thr Ala Gln Arg Met Ile Lys Glu Lys Ile Asn Leu Phe Gly Asn Leu 
        435                 440                 445             


Ser Glu Val Thr Lys His Lys Ser Asp Phe Phe Glu Lys Glu Ser Ala 
    450                 455                 460                 


Ala Gln Gly Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Trp Ala Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Val Tyr Ile Asp Met Ile Gly Lys Glu Gly Lys Ala 
                485                 490                 495     


Lys Glu Ile Gln Val Gln Ile Asn Lys Tyr Arg Lys Gln Leu Asn Pro 
            500                 505                 510         


Ala Pro Gln Arg Asp Lys Arg Ile Ser Lys Lys Glu Ile Ile Glu Gln 
        515                 520                 525             


Leu Tyr Lys Glu Lys Val Val Tyr Gly Asp Pro Thr Leu Met Leu Ser 
    530                 535                 540                 


Ala Asn Glu Leu Met Ala Leu Leu Tyr Glu Leu Ile Val Asn Gly Lys 
545                 550                 555                 560 


Ser Gly Ala Glu Leu Glu Asn Lys Ile Val Glu Gln Ile Ile Ala Arg 
                565                 570                 575     


Tyr Glu Gln Ile Glu Ala Tyr Asp Pro Thr Thr Gln Gln Leu Pro Thr 
            580                 585                 590         


Asn Gln Met Pro His Lys Leu Gln Lys Ser Arg Lys Asp Ser Lys Val 
        595                 600                 605             


Thr Asp Thr Asp Lys Leu Leu Lys Thr Ile Asp Lys Glu Ile Asp Glu 
    610                 615                 620                 


Gly Asn Lys Lys Leu Glu Leu Ile Ala Cys His Arg Lys Glu Trp Glu 
625                 630                 635                 640 


Glu Ala Glu Gln Arg Lys Lys Ser Gly Lys Arg Asn Asn Pro Gly Thr 
                645                 650                 655     


Lys Ser Arg Lys His Leu Phe Tyr Ala Ser Glu Met Gly Glu Glu Ala 
            660                 665                 670         


Thr Trp Ile Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Pro Ala Arg 
        675                 680                 685             


Ala Glu Trp Lys Gly Thr His His Ser Glu Leu Gln Arg Leu Leu Ala 
    690                 695                 700                 


Phe Tyr Ser Thr Gln Arg Leu Glu Ala Trp Gln Leu Val Glu Ser Val 
705                 710                 715                 720 


Trp Thr Ala Asn Thr His Ser Phe Trp Glu Glu Asn Phe Lys Glu Ala 
                725                 730                 735     


Phe Tyr Lys Pro Glu Phe Glu Asn Phe Tyr Gly Ala Tyr Ile Glu Ile 
            740                 745                 750         


Arg Thr Lys Ile Leu Thr Thr Cys Arg Ser Ile Leu Glu Asn Asn Pro 
        755                 760                 765             


Glu Ala Thr Met Asn Asn Asp Thr Glu Lys Glu Trp Asp Lys Val Phe 
    770                 775                 780                 


Thr Leu Phe Asp Lys Arg Leu Tyr Arg Thr Ser Thr Thr Asp Glu Gln 
785                 790                 795                 800 


Lys Lys Gln Leu Leu Thr Lys Pro Phe Ala Phe Pro Arg Gly Leu Phe 
                805                 810                 815     


Asp Asp Lys Pro Thr Phe Leu Pro Gly Ser Lys Pro Asn Glu Asn Pro 
            820                 825                 830         


Glu Arg Phe Ala Ala Trp Tyr Ser Tyr Gly Tyr Thr Tyr Ser Gly Lys 
        835                 840                 845             


Phe Gln Ser Phe Tyr Asp Met Pro Arg Asn Tyr Ser Asp Trp Tyr Lys 
    850                 855                 860                 


Lys Leu Lys Glu Asp Gly Lys Leu Pro Arg Leu Asp Lys Lys Thr Glu 
865                 870                 875                 880 


Gln Glu Lys Ile Leu Arg Phe Arg Met Asp Cys Asp Leu Asn Ile Lys 
                885                 890                 895     


His Ile Arg Phe Gln Asp Ile Tyr Val Lys Leu Met Val Asp Ser Leu 
            900                 905                 910         


Tyr Lys Ala Val Phe Gly Gln Gln Pro Glu Phe Asp Leu Ser His Leu 
        915                 920                 925             


Tyr Asp Thr Arg Ser Glu Arg Tyr Glu Asn Asn Thr Ile Ala Gln Arg 
    930                 935                 940                 


Gln Lys Ser Arg Gln Glu Gly Asp Asn Ser Asp Asn Ala Ile Asn Glu 
945                 950                 955                 960 


Asn Tyr Val Trp Asn Lys Thr Phe Ala Ile Ser Leu Tyr Asn Gly Arg 
                965                 970                 975     


Ile Thr Glu Ser Gln Val Lys Leu Lys Asp Val Gly Lys Phe Arg Arg 
            980                 985                 990         


Phe Ala Thr Asp Pro Arg Val Gln  Thr Leu Ile Ser Tyr  Asp Asp Thr 
        995                 1000                 1005             


Arg Thr  Trp Thr Lys Leu Glu  Ile Glu Asn Glu Leu  Asp Asn Lys 
    1010                 1015                 1020             


Ala Asp  Ala Tyr Glu Pro Ile  Arg Arg Thr Gln Ser  Leu Lys Ala 
    1025                 1030                 1035             


Ile Gln  Gln Leu Glu Lys Asn  Ile Leu Lys Lys Asn  Gly Phe Asn 
    1040                 1045                 1050             


Gly Lys  Gln His Pro Glu Glu  Leu Lys His Asn Gly  Asn Pro Asn 
    1055                 1060                 1065             


Phe Arg  Lys Tyr Ile Ala Asn  Gly Leu Leu Lys His  Arg Thr Asp 
    1070                 1075                 1080             


Ile Arg  Gln Glu Glu Leu Ala  Leu Ile Ser Asp Thr  Glu Phe Gln 
    1085                 1090                 1095             


Glu Ile  Gly Leu Glu Arg Ile  Arg Gln Thr Asn Pro  Leu Ile Gln 
    1100                 1105                 1110             


Lys Ala  Tyr Leu Leu Ile Leu  Leu Arg Asn Lys Phe  Gly His Asn 
    1115                 1120                 1125             


Gln Leu  Pro Asp Gln Glu His  Phe Arg Leu Met Arg  Ser Ile Tyr 
    1130                 1135                 1140             


Pro Tyr  Asn Gln Gln Glu Ser  Tyr Ser Ala Tyr Phe  Asn His Val 
    1145                 1150                 1155             


Ile Thr  Gln Ile Ile Glu Glu  Leu Asn Thr 
    1160                 1165             


<210>  1381
<211>  1057
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1381

Met Thr Ile Lys Glu Gln Ser His Phe Ala Ala Tyr Tyr Asn Met Ala 
1               5                   10                  15      


Arg His Asn Met Tyr Glu Thr Leu Cys Tyr Ile Ser Lys Ile Ser Gly 
            20                  25                  30          


Ile Gln Glu Gly Glu Asp Asn Lys Glu Ser Lys Ile Glu Asp Met Gln 
        35                  40                  45              


Leu Leu Arg Val Leu Thr Thr Lys Gly His Pro Glu Glu Lys Ile Arg 
    50                  55                  60                  


Ile Glu Lys Leu Ile Tyr Lys His Leu Pro Leu Phe Arg Pro Ala Val 
65                  70                  75                  80  


Glu Asp Leu Arg Lys Lys Ser Lys Glu Asn Val Lys Ser Pro Glu Leu 
                85                  90                  95      


Leu Ala Lys Val Ile Lys Asn Trp Ala Lys Val Ile Thr Tyr Tyr Arg 
            100                 105                 110         


Asp Lys Phe Thr His Tyr Val Phe Ile Asp Lys Arg His Glu Asn Lys 
        115                 120                 125             


Glu Phe Leu Asn Ala Glu Met Ser Val Ala Asn Asp Leu Asn Gln Ile 
    130                 135                 140                 


Phe Thr Ala Ser Ala Arg Val Ile Lys Glu Arg Phe Gly Leu Ser Thr 
145                 150                 155                 160 


Glu Leu Glu Phe Leu Thr Lys Gly Arg Tyr Arg Thr Gln Thr Ile Asp 
                165                 170                 175     


Gly Lys Arg Ser Thr Lys Leu Asn Pro Asn Phe Ile Tyr Ser Leu Gln 
            180                 185                 190         


Asp Lys Asn Glu Arg Leu Asn Lys Met Gly Leu Ile Phe Leu Ala Cys 
        195                 200                 205             


Gln Leu Ile Glu Lys Lys Tyr Ala Ser Met Leu Phe Asp Gln Gln Gly 
    210                 215                 220                 


Tyr Met Gly Arg Asp Ile Tyr Phe Asp Phe Thr Pro Ala Gln Cys Lys 
225                 230                 235                 240 


Tyr Ile Arg Glu Val Phe Ser Ala His Arg Ile Val Leu Pro Arg Gly 
                245                 250                 255     


Arg Met Asp Val Glu Arg Asn Glu Ile Thr Ile Ala Met Asp Met Phe 
            260                 265                 270         


Asn Glu Leu Gly Lys Cys Pro Lys Glu Leu Phe Glu Ile Ile Ser Lys 
        275                 280                 285             


Glu Glu Gln Lys Arg Phe Arg Thr Lys Ser Glu Thr Thr Gly Glu Glu 
    290                 295                 300                 


Val Leu Leu Met Arg His Ser Asp Arg Phe Ala Thr Leu Ala Leu Gln 
305                 310                 315                 320 


Tyr Ile Asp Asn Arg Lys Val Phe Glu Lys Ile Arg Phe Gln Leu Ser 
                325                 330                 335     


Leu Gly Lys Tyr Arg Tyr Lys Phe Tyr Asp Lys Thr Cys Val Asp Gly 
            340                 345                 350         


Asp Thr His Val Arg Ile Leu Gln Lys Glu Leu Asn Gly Phe Gly Arg 
        355                 360                 365             


Ile Asn Glu Ile Glu Leu Leu Lys Glu Glu Lys Trp Gly Gly Leu Ile 
    370                 375                 380                 


Arg Lys Phe Glu Asp Ala Lys Ile Asp Thr Ala Glu Thr Lys Pro Tyr 
385                 390                 395                 400 


Ile Thr Asp Gln Tyr Pro Gln Tyr Leu Phe Asn Gly Asn Arg Ile Gly 
                405                 410                 415     


Ile Tyr Phe Asn Ser Ala His Gly Lys Ala Met Arg Asn Gly Ala Tyr 
            420                 425                 430         


Ile Pro Asp Ile Glu Ser Gly Ala His Cys Ile Gln Pro Ile Cys Trp 
        435                 440                 445             


Ile Ser Asn Tyr Glu Leu Pro Ala Leu Ile Phe His His Ile Leu Thr 
    450                 455                 460                 


Lys Asp Glu Lys Lys Ser Leu Thr Glu Lys Ile Ile Ile Asp Cys Val 
465                 470                 475                 480 


Glu Arg Tyr Lys Lys Leu Phe Asn Asp Ile Ala Glu Gly Lys Val Ala 
                485                 490                 495     


Arg Thr Gly Asn Ala Thr Ser Asp Phe Glu Met Ile Ser Lys Glu Tyr 
            500                 505                 510         


Gly Ile Glu Lys Ser Asp Ile Pro Arg Glu Leu Gln Asp Tyr Phe Asn 
        515                 520                 525             


Gly Thr Glu Arg Asp Gly Ile Glu Gln Tyr Ala Lys Ala Gln Ile Arg 
    530                 535                 540                 


Glu Met Ile Glu Glu Asn Arg Ile Arg Leu Glu Gln Phe Asn Ser Lys 
545                 550                 555                 560 


Leu Lys Lys Ile Glu Asp Gly Glu Val Lys Tyr Gly Lys Arg Asp Tyr 
                565                 570                 575     


Thr Glu Ile Arg Thr Gly Glu Leu Ala Gln Tyr Leu Ala Lys Asp Ile 
            580                 585                 590         


Val Met Phe Met Pro Lys Ala Lys Tyr Lys Pro Thr Ser Lys Asn Tyr 
        595                 600                 605             


Asn Val Met Gln Ala Leu Leu Ala Thr Phe Asn Gly Ser Glu Ser Gly 
    610                 615                 620                 


Ser Thr Leu Asp Glu Val Asp Asp Met Phe Asp Asn Ile Lys Ala Cys 
625                 630                 635                 640 


Tyr Trp Lys Asn Glu Ser Asp Asn His Pro Phe Leu Glu Tyr Val Leu 
                645                 650                 655     


Gly Glu Glu Pro Lys Asp Ile Ile Ala Phe Tyr Lys Ile Tyr Leu Glu 
            660                 665                 670         


Leu Arg Gly Glu Tyr Leu Asp Lys Cys Ile Lys Lys Met Asp Leu Ala 
        675                 680                 685             


Thr Ile Pro Phe Ile His Thr Glu Arg Lys Arg Trp Glu Lys Arg Asp 
    690                 695                 700                 


Glu Lys Phe Phe Lys Glu Leu Ala Gln Arg Tyr Ala Thr Gln Pro Ile 
705                 710                 715                 720 


Glu Leu Pro Arg Gly Leu Tyr Asp Arg Ala Ile Lys Glu Tyr Leu Lys 
                725                 730                 735     


Ser Lys Ser Ile Leu Glu Asp Val Ile Ala Gln Glu Gln Cys Asn Val 
            740                 745                 750         


Thr Tyr Leu Ile Ala Arg Tyr Met Gln Asp Val Leu Lys Asp Asp Ser 
        755                 760                 765             


Gln Gln Phe Tyr Ser Leu Pro Arg His Tyr Ser Cys Leu Ser Glu Lys 
    770                 775                 780                 


Asp Lys Tyr Leu Ser Leu Thr Glu Arg Glu Ala Ile Ala Lys Ser Asp 
785                 790                 795                 800 


Ala Leu Asn Ser Phe Lys Lys Arg Glu Arg Glu Lys Glu Asn Glu Asn 
                805                 810                 815     


Arg Arg Gly Asn Arg Arg Tyr Asn Lys Gly Glu Asn Lys Asn Thr Ile 
            820                 825                 830         


Lys Asp Arg Asp Thr Glu Glu Lys Phe Asn Ser Leu Tyr Arg Lys Met 
        835                 840                 845             


Asp Asn Asn Glu Arg Ile Leu Arg Arg Tyr Lys Val Gln Asp Met Leu 
    850                 855                 860                 


Leu Tyr Leu Leu Ala Cys Asp Ile Ile Lys Gly Ile Met Arg Glu Asp 
865                 870                 875                 880 


Phe Gly Tyr Lys Leu Ser Met Ile Thr Asp Gly Lys Asn Ser Asn Phe 
                885                 890                 895     


Phe Asp Tyr Lys Met Pro Glu Phe Lys Thr Thr Ile Thr Leu Lys Glu 
            900                 905                 910         


Gly Lys Lys Phe Thr Ile Lys Gln Gln Tyr Leu Lys Ile Lys Asn Tyr 
        915                 920                 925             


Gly Asp Phe Leu Lys Phe Ile Phe Asp Leu Arg Ile Asp Ser Leu Leu 
    930                 935                 940                 


Ser Asn Gly Thr Lys Val Glu Ile Asp Arg Asn Ile Leu Glu Asp Glu 
945                 950                 955                 960 


Leu Ser Asn Tyr Asp Gly Ser Arg Pro Lys Val Phe Glu Thr Leu Leu 
                965                 970                 975     


Met Ile Glu Lys Ile Val Val Glu Lys His Lys Glu Leu Lys Asp Leu 
            980                 985                 990         


Glu His Ile Thr Phe Gly Asp Val  Leu Asn Val Ile Lys  Met Glu Glu 
        995                 1000                 1005             


Gly Glu  Lys Lys Ile Leu Arg  Leu Ile Arg Asn Ala  Phe Ser His 
    1010                 1015                 1020             


Asn Tyr  Tyr Pro Thr Ile Lys  Asp Val Asn Tyr Asp  Asn Met Pro 
    1025                 1030                 1035             


Glu Val  Ala Glu Ser Leu Lys  Asp Ile Leu Glu Lys  Glu Ser Lys 
    1040                 1045                 1050             


Lys Leu  Thr Asn 
    1055         


<210>  1382
<211>  1199
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1382

Met Asn Thr Phe Ile Asp Ser Phe Ile Arg Arg Val Gln Ile Gln Asn 
1               5                   10                  15      


Gln Asn Gln Ser Trp Pro Lys Arg Pro Lys Tyr Val Arg Pro Val Glu 
            20                  25                  30          


Asn Ile Arg Pro Asp Asp Leu Ala Phe Gln Ser His Phe Thr Ala Tyr 
        35                  40                  45              


Leu Asn Met Ala Arg Gln Asn Cys Cys Ile Ile Leu Gly His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Gly Phe Lys Ala Ser Ser Val Lys Asp Thr Thr Leu Thr 
65                  70                  75                  80  


Ser Ser Pro Leu Leu Gly Gln Asn Gly Leu Leu Ser Pro Lys Lys Glu 
                85                  90                  95      


Val Ser Asp Leu Ile Arg Gly Arg Leu Leu Ser Ala Phe Pro Met Leu 
            100                 105                 110         


Asp Pro Met Ile Arg Tyr Arg Lys Ala Val Asp Lys Glu Lys Asp Asp 
        115                 120                 125             


Tyr Ala Arg Ile Ile Ile Thr Ser Glu Asp Val Ser Glu Met Leu Arg 
    130                 135                 140                 


Asp Leu Leu Asp Val Leu Ser Tyr Tyr Arg Asp Met Ala Ser His Val 
145                 150                 155                 160 


Val Phe Asn Asp Asp Arg Ser Val Ser Ala Glu Phe Ala Ser Lys Glu 
                165                 170                 175     


Lys Lys Val Ala Glu Cys Leu Asn Tyr Met Met Thr Val Ser Leu Arg 
            180                 185                 190         


Ile Val Lys Asp Arg Phe Ser Leu Ala Val Ser Asp Leu Asp Phe Tyr 
        195                 200                 205             


Asn Arg Asn Arg Tyr Met Met Val Asn Arg Lys Pro Leu Leu Asn Ala 
    210                 215                 220                 


Gly Phe Ala His Ala Val Arg Thr Glu Asp Tyr Arg Leu Thr Leu Met 
225                 230                 235                 240 


Gly Leu Val Leu Leu Cys Cys Gln Phe Ile Glu Lys Gln Tyr Ala Ser 
                245                 250                 255     


Met Phe Phe Asp Ala Leu Asp Lys His Ser Asn Gly Ala Arg Phe Tyr 
            260                 265                 270         


Gly Ile Ala Asp Ala Met Pro Met Val Asn Val Gly Thr Lys Asp Lys 
        275                 280                 285             


Pro Lys Lys Ile Pro Met Tyr Thr Gly Asp Glu Ala Gln Lys Gln Val 
    290                 295                 300                 


Gln Lys Gln Arg Met Ala Leu Arg Glu Ala Tyr Ser Val Tyr Arg Val 
305                 310                 315                 320 


Arg Ile Pro Lys Glu Arg Leu Glu Ser Thr Arg Ser Asp Met Ala Leu 
                325                 330                 335     


Ala Leu Asp Ile Leu Asn Glu Leu Gly Lys Cys Pro Glu Glu Leu Phe 
            340                 345                 350         


Glu His Leu Ser Pro Glu Asp Arg Glu Ser Phe Lys Asn Glu Glu Gly 
        355                 360                 365             


Val Leu Met Lys Arg Tyr Ser Asp Arg Phe Pro Gln Leu Ala Leu Arg 
    370                 375                 380                 


Trp Leu Asp Glu Asn Glu Lys Phe Asn Asn Leu Arg Phe His Val Thr 
385                 390                 395                 400 


Phe Gly Lys Tyr Arg Trp Leu Phe Cys Gln Asp Lys Lys Cys Ala Asp 
                405                 410                 415     


Gly Ser Val Arg Pro Arg Trp Leu Gln Lys Glu Leu Asn Gly Phe Gly 
            420                 425                 430         


Arg Ile Gln Thr Val Glu Arg Lys Arg Thr Gly Leu Glu Pro Gly Trp 
        435                 440                 445             


Asp Gly Thr Gly Leu Ile Arg Lys Phe Glu Glu Val Val Thr Asp Glu 
    450                 455                 460                 


Val Gln Lys Glu Pro Tyr Ile Thr Asp Phe Arg Thr Gln Tyr Leu Phe 
465                 470                 475                 480 


Asn Arg Asp Lys Ile Gly Ile Ser Leu Ser Glu Tyr Met Pro Gly Ile 
                485                 490                 495     


Gly Asp Ile His Ser Gly Lys Glu Trp Gly Lys His Ala Gly Val Pro 
            500                 505                 510         


Asp Phe Tyr Leu Ser Val Tyr Asp Ile Pro Ala Met Leu Phe Leu Thr 
        515                 520                 525             


Trp Leu Leu Gly Lys Asn Ser Ser Ala Val Glu Lys Leu Leu Ala Asn 
    530                 535                 540                 


Cys Lys Ala Ala Tyr Met Lys Leu Phe Asp Asp Leu Ala Lys Gly Lys 
545                 550                 555                 560 


Trp Glu Gly Glu Arg Asn Val Ser Asp Tyr Cys Ala Gly Glu Gly Thr 
                565                 570                 575     


Val Arg Tyr Thr Leu Arg Trp Tyr Asp Val Pro Met Lys Ile Arg Arg 
            580                 585                 590         


Lys Met Pro Leu Leu Gly Gly Asp Arg Asp Phe Glu Glu Lys Lys Ser 
        595                 600                 605             


Phe Glu Thr Leu Ala Gln Glu Ala Leu Thr Arg Met Leu Gln Arg Thr 
    610                 615                 620                 


Glu Asn Gln Leu Glu Lys Phe Asp Arg Asp Leu Ala Ala Ala Arg Asp 
625                 630                 635                 640 


Leu Lys Ala Asn Lys Gln Gly Lys Asp Arg Phe Val Asp Ile Arg Ala 
                645                 650                 655     


Gly Ser Leu Ala Thr Phe Leu Ala Arg Asp Ile Val Arg Leu Met Pro 
            660                 665                 670         


Val Ser Asp Asn Gly Arg Asn Lys Pro Thr Gly Leu Asn Tyr Ser Ile 
        675                 680                 685             


Val Gln Lys Ala Ile Ala Thr Tyr Lys Pro Ser Glu Gly Gly Leu Asp 
    690                 695                 700                 


Thr Leu Thr Gly Val Phe Arg Asp Ala Arg Ile Ile Gly Val Lys Gly 
705                 710                 715                 720 


Gly Ser His Pro Phe Leu Glu Arg Leu Leu Val Glu Lys Lys Pro Ser 
                725                 730                 735     


Ser Val Leu Ala Leu Tyr Arg His Tyr Leu Glu Tyr Arg Lys Glu Tyr 
            740                 745                 750         


Leu Lys Lys Ala Leu Glu Asp Glu Asn Lys Ala Glu Leu Lys Asn Leu 
        755                 760                 765             


Pro Phe Leu Lys Ser Gly Arg Gln Lys Tyr Ala Val Asp Gln Ala Asp 
    770                 775                 780                 


Tyr Ala Arg Arg Leu Ala Glu Ser Tyr Arg Asn Cys Pro Ile Tyr Leu 
785                 790                 795                 800 


Pro Thr Gly Ile Phe Thr Asp Met Leu Lys Asp Gln Leu Ala Lys Ile 
                805                 810                 815     


Asp Val Met Lys Pro Val Leu Glu Asn Asp Lys Val Asn Ala Ser Tyr 
            820                 825                 830         


Leu Ile Ala Gln Tyr Phe Glu Lys Val Glu His Asp Ser Glu Gln Pro 
        835                 840                 845             


Leu Tyr Arg Leu Lys Arg Asn Tyr Arg Val Phe Asp Leu Leu Glu Phe 
    850                 855                 860                 


Thr Asp Glu Pro Lys Tyr Trp Arg Leu Asn Glu Arg Ser Asp Lys Ala 
865                 870                 875                 880 


Gly Lys Tyr Gly Leu Ala Lys Arg Asn Ile Phe Trp Asn Arg Met Gly 
                885                 890                 895     


Glu Tyr Tyr Lys Gly Leu Lys Lys Phe Tyr Lys Gly Tyr Glu Ser Lys 
            900                 905                 910         


Arg Thr Ala Val Asp Trp Arg Glu Lys Leu Lys Ile Val Glu Ala Glu 
        915                 920                 925             


His Ala Met Trp Asn Arg Leu Lys Asp Ala Ser Gly Glu Ala Arg Leu 
    930                 935                 940                 


Lys Met Lys Asp Gly Val Phe Tyr Ser Arg Leu Leu Ser Ala Arg Lys 
945                 950                 955                 960 


Glu Tyr Asp Asp Cys Glu Arg Ala Leu Arg Arg Leu Lys Val Gln Asp 
                965                 970                 975     


Ile Val Leu Phe Leu Ala Ala Arg Glu Thr Leu Ile Leu Pro Lys Asp 
            980                 985                 990         


Lys Val Phe Arg Leu Lys Asn Leu  Ser Leu Ser Glu Gly  Asn Lys Asn 
        995                 1000                 1005             


Ile Leu  Ser Ser Ala Ile Asp  Glu Phe Ser Val Asp  Val Val Trp 
    1010                 1015                 1020             


Thr Glu  Lys Glu Gly Ala Ala  Lys Val Thr His Ser  Ala Ser Ile 
    1025                 1030                 1035             


Lys Glu  Asn Asp Val Val Ile  Lys Asn Tyr Gly Arg  Met Phe Arg 
    1040                 1045                 1050             


Leu Leu  His Asp Asp Arg Val  Lys Thr Leu Leu Pro  His Ile Tyr 
    1055                 1060                 1065             


Asp Ser  Ala Leu Ser Glu Asn  Ile Thr Gly Asp Arg  Ile Thr Val 
    1070                 1075                 1080             


Lys Asp  Asn Lys Val Ile Ile  Asp Lys Ser Leu Phe  Asp Glu Asp 
    1085                 1090                 1095             


Leu Met  Asn Tyr Asp Leu Arg  Arg His Glu Ile Cys  Glu Ile Ile 
    1100                 1105                 1110             


Leu Arg  Phe Glu Ala Ala Ser  Ile Lys Arg Phe Gly  Leu Asp Gly 
    1115                 1120                 1125             


Arg Val  Asp Phe Lys Ala Ala  Leu Asp Ala Leu Thr  Gly Arg Ser 
    1130                 1135                 1140             


Leu Leu  Asn Asp Glu Asp Ala  Arg Ile Leu Ser Ala  Ile Arg Asn 
    1145                 1150                 1155             


Ala Tyr  Asn His Asn Lys Tyr  Pro Ala Lys Gly Thr  Asp Val Lys 
    1160                 1165                 1170             


Val Asn  Val Met Ala Leu Pro  Lys Leu Thr Glu Asp  Leu Leu Arg 
    1175                 1180                 1185             


Ile Phe  Ser Asp Thr Gly Asn  Asn Arg Val Arg 
    1190                 1195                 


<210>  1383
<211>  1149
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1383

Met Met Glu Lys Glu Asn Val Gln Gly Ser His Ile Tyr Tyr Glu Pro 
1               5                   10                  15      


Thr Asp Lys Cys Phe Trp Ala Ala Phe Tyr Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Leu Thr Val Ala His Ile Asn Ser Phe Val Asn Ser Lys Lys 
        35                  40                  45              


Gly Ile Asn Asn Asp Asp Lys Val Leu Asp Val Ile Asp Ala Trp Ser 
    50                  55                  60                  


Lys Phe Asp Ala Asp Leu Leu Met Gly Ala Arg Leu Asn Lys Leu Ile 
65                  70                  75                  80  


Leu Lys His Phe Pro Phe Leu Lys Ala Pro Leu Tyr Lys Gln Thr Lys 
                85                  90                  95      


Lys Glu Ala Ser Lys Gln Tyr Lys Glu Glu Asn Pro Ser Ala Asp Lys 
            100                 105                 110         


Gln Lys Ile Glu Lys Glu Ser Ala Lys Thr Ala Met Ala Asn Thr Leu 
        115                 120                 125             


Glu Leu Glu Asn Val Arg Lys Ile Leu Arg Glu Phe Leu Gln Gln Leu 
    130                 135                 140                 


Glu Asp Leu Arg Asn His Phe Ser His Tyr Asn Tyr Asn Ser Pro Asp 
145                 150                 155                 160 


Glu Lys Thr Glu Val Lys Phe Asp Asn Ser Phe Cys Asn Lys Leu Tyr 
                165                 170                 175     


Tyr Val Phe Asp Ala Ala Leu Gln Met Val Lys Asp Asp Asn Arg Met 
            180                 185                 190         


Asn Pro Glu Ile Asn Met Gln Thr Asp Phe Glu His Leu Val Arg Leu 
        195                 200                 205             


Gly Pro Asn Gly Glu Ile Ser His Ser Phe Lys Tyr Lys Phe Ile Glu 
    210                 215                 220                 


Pro Asp Gly Thr Ile Asn Asn Asn Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Lys Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Asn Tyr Met Arg Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Asn Arg Met Val Ile Pro Lys Leu Arg Leu Glu Thr Asp Tyr 
        275                 280                 285             


Asp Asn His Gln Leu Met Phe Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Leu Ser Leu Tyr Lys Arg Leu Lys Lys Glu Asp Gln Asp Lys Phe 
305                 310                 315                 320 


Gln Val Pro Ile Glu Phe Leu Asp Glu Asp Asn Glu Ala Asp Asn Gln 
                325                 330                 335     


Tyr Gln Glu Asn Ala Asn Ser Asp Glu Asn Pro Thr Glu Glu Thr Asp 
            340                 345                 350         


Pro Leu Lys Asn Thr Leu Val Arg His Gln His Arg Phe Pro Tyr Phe 
        355                 360                 365             


Val Leu Arg Tyr Phe Asp Leu Asn Glu Val Phe Lys Gln Leu Arg Phe 
    370                 375                 380                 


Gln Ile Asn Leu Gly Cys Tyr His Phe Ser Ile Tyr Asp Lys Thr Ile 
385                 390                 395                 400 


Gly Glu Arg Thr Glu Lys Arg His Leu Thr Arg Thr Leu Phe Gly Phe 
                405                 410                 415     


Asp Arg Leu Gln Asn Phe Ser Val Lys Leu Gln Pro Gln His Trp Lys 
            420                 425                 430         


Asn Met Val Lys His Leu Asp Thr Glu Glu Ser Ser Asp Lys Pro Tyr 
        435                 440                 445             


Leu Ser Asp Ala Met Pro His Tyr Gln Ile Glu Asn Glu Lys Ile Gly 
    450                 455                 460                 


Ile His Phe Leu Lys Thr Asp Thr Glu Lys Lys Glu Thr Val Trp Pro 
465                 470                 475                 480 


Ser Leu Glu Val Glu Glu Val Ser Ser Asn Arg Asn Lys Tyr Lys Ser 
                485                 490                 495     


Glu Lys Asn Leu Thr Ala Asp Ala Phe Leu Ser Thr His Glu Leu Leu 
            500                 505                 510         


Pro Met Met Phe Tyr Tyr Gln Leu Leu Ser Ser Glu Glu Lys Thr Arg 
        515                 520                 525             


Ala Ala Ala Gly Asp Lys Val Gln Gly Val Leu Gln Ser Tyr Arg Lys 
    530                 535                 540                 


Lys Ile Phe Asp Ile Tyr Asp Asp Phe Ala Asn Gly Thr Ile Asn Ser 
545                 550                 555                 560 


Met Gln Lys Leu Asp Glu Arg Leu Ala Lys Asp Asn Leu Leu Ser Gly 
                565                 570                 575     


Asn Met Pro Gln Gln Met Leu Ala Ile Leu Glu His Gln Glu Pro Asp 
            580                 585                 590         


Met Glu Gln Lys Ala Lys Glu Lys Leu Asp Leu Leu Ile Thr Glu Thr 
        595                 600                 605             


Glu Glu Arg Ile Asp Lys Leu Asn Ala Gln Phe Lys Gln Lys Val Arg 
    610                 615                 620                 


Ile Gly Lys Arg Arg Ala Gly Leu Pro Lys Val Gly Ser Ile Ala Asp 
625                 630                 635                 640 


Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Ala Lys Arg Ser Ala 
                645                 650                 655     


Asp Asn Thr Gly Val Pro Gly Ser Lys Ala Asn Ser Thr Glu Tyr Arg 
            660                 665                 670         


Leu Leu Gln Glu Ala Leu Ala Phe Tyr Ser Thr Tyr Lys Asp Arg Leu 
        675                 680                 685             


Glu Pro Tyr Phe Arg Gln Val Asn Leu Ile Gly Asp Thr Asn Pro His 
    690                 695                 700                 


Pro Phe Leu His Arg Val Asp Trp Lys Lys Cys Asn His Leu Leu Ser 
705                 710                 715                 720 


Phe Tyr His Asp Tyr Leu Glu Ala Lys Lys Arg Tyr Leu Ser Asn Leu 
                725                 730                 735     


Ser Pro Ala Asp Trp Gln Lys His Gln His Phe Leu Leu Leu Lys Val 
            740                 745                 750         


Arg Lys Asp Ile Gln Asn Glu Lys Lys Asp Trp Lys Lys Ser Leu Val 
        755                 760                 765             


Ala Gly Trp Lys Asn Gly Phe Asn Leu Pro Arg Gly Leu Phe Thr Glu 
    770                 775                 780                 


Ser Ile Lys Thr Trp Phe Ser Thr His Ala Asp Lys Val Gln Ile Thr 
785                 790                 795                 800 


Asp Thr Lys Leu Phe Glu Asn Arg Val Gly Leu Ile Ala Lys Leu Ile 
                805                 810                 815     


Pro Leu Tyr Tyr Asp Lys Val Tyr Asn Asp Lys Pro Gln Pro Phe Tyr 
            820                 825                 830         


Gln Tyr Pro Phe Asn Ile Asn Asp Arg Tyr Lys Pro Glu Asp Ala His 
        835                 840                 845             


Lys Gln Phe Thr Ala Ala Ser Ser Lys Leu Trp Asn Glu Lys Lys Met 
    850                 855                 860                 


Leu Tyr Lys Asn Ala Gln Pro Asp Ser Ser Asp Lys Ile Glu Tyr Pro 
865                 870                 875                 880 


Gln Tyr Leu Asp Phe Leu Ser Trp Lys Lys Leu Glu Arg Glu Leu Arg 
                885                 890                 895     


Met Leu Arg Asn Gln Asp Met Met Val Trp Leu Met Cys Lys Asp Leu 
            900                 905                 910         


Phe Ala Gln Cys Thr Val Glu Gly Val Glu Phe Ala Asp Leu Lys Leu 
        915                 920                 925             


Ser Gln Leu Glu Val Asp Val Thr Val Gln Asp Asn Leu Asn Val Leu 
    930                 935                 940                 


Asn Asn Val Ser Ser Met Ile Leu Pro Leu Ser Val Tyr Pro Ser Asp 
945                 950                 955                 960 


Ala Gln Gly Asn Ile Leu Arg Asn Ser Lys Pro Leu His Thr Val Tyr 
                965                 970                 975     


Val Gln Glu Lys Asn Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ser 
            980                 985                 990         


Leu Leu Lys Asp Arg Arg Leu Asn  Gly Leu Phe Ser Phe  Ile Ala Ala 
        995                 1000                 1005             


Glu Gly  Glu Asp Leu Gln Gln  His Pro Leu Thr Lys  Asn Arg Leu 
    1010                 1015                 1020             


Glu Tyr  Glu Leu Ser Ile Tyr  Gln Thr Met Arg Ile  Ser Val Phe 
    1025                 1030                 1035             


Glu Gln  Thr Leu Gln Leu Glu  Lys Ala Ile Leu Thr  Arg Asn Glu 
    1040                 1045                 1050             


Met Leu  Cys Gly Asn Asn Phe  Asn Asn Leu Leu Asn  Ser Trp Ser 
    1055                 1060                 1065             


Glu Tyr  Arg Thr Asp Lys Lys  Thr Leu Gln Pro Asp  Ile Asp Phe 
    1070                 1075                 1080             


Leu Ile  Ala Val Arg Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met 
    1085                 1090                 1095             


Ser Thr  Asn Thr Val Met Gln  Gly Ile Glu Lys Phe  Asn Ile Arg 
    1100                 1105                 1110             


Thr Ser  Arg Leu Ala Glu Lys  Asp Gly Leu Gly Ile  Ala Ser Gln 
    1115                 1120                 1125             


Leu Ala  Lys Lys Thr Lys Asp  Ala Ala Ser Arg Leu  Gln Asn Ile 
    1130                 1135                 1140             


Ile Asn  Gly Gly Thr Asn 
    1145                 


<210>  1384
<211>  1300
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1384

Met Asn Asn Ser Val Asn Ser Phe Ala Leu Val Asn Glu Ser Ser Gly 
1               5                   10                  15      


Arg Gly Lys Tyr Val Ala Gly Thr Tyr Phe Glu Ile Ala Ile His Asn 
            20                  25                  30          


Phe Phe Lys Thr Ile Asp Phe Val Leu Arg Arg Val Asn Ile Arg Lys 
        35                  40                  45              


Ser Asp Lys Gln Trp Ala Asp Gly Phe Ala His Leu Gly Asn Trp Thr 
    50                  55                  60                  


Asp Glu Arg Met Gly Lys Val Leu Glu Gln Leu Ala Leu Ala Glu Met 
65                  70                  75                  80  


Ser Pro Thr Gln Leu Ser Arg Leu Ser Arg Leu Leu Tyr His His Phe 
                85                  90                  95      


Pro Phe Phe Ser Pro Ile Met Ala Asp Ala Ala Asp His Gln Val Tyr 
            100                 105                 110         


Leu Arg Val Asn Glu Ile Lys Glu Ile Glu Gln Glu Ile Thr Glu Ser 
        115                 120                 125             


Asp Lys Lys Ile Lys Lys Asn Pro Val Asn Lys Glu Leu Val Gln Ser 
    130                 135                 140                 


Ile Asn Glu Ala Arg Ile Arg Leu Lys Ala Ala His Asn Ser Leu Glu 
145                 150                 155                 160 


Arg Gln Leu Ala Ser Thr Thr Ala Lys Glu Val Leu Ala Lys Leu Ala 
                165                 170                 175     


Val Met Ala Tyr Ala Met Asn Phe Tyr Arg Asn Gln Tyr Ser His Lys 
            180                 185                 190         


Cys His Phe Glu Thr Leu Asn Glu Lys Thr Leu Gln Glu Glu Asn Glu 
        195                 200                 205             


Gln Asn Leu Ala Phe Trp Leu Glu Val Ile Phe Lys Gly Ala Arg Ser 
    210                 215                 220                 


Ile Ile Leu Asp Arg Lys Glu His Ser Gln Glu Asp Thr Lys Phe Leu 
225                 230                 235                 240 


Thr Gln Asp Gly Asn Leu His Tyr Asn Val Asn Lys Ser Lys Lys Ser 
                245                 250                 255     


Thr Arg Asn Pro Asn Phe Tyr Phe Ser Pro Gly Lys Lys Asn Gly Gln 
            260                 265                 270         


Lys Trp Leu Ile Thr Asp Phe Gly Arg Tyr Tyr Phe Cys Ser Leu Phe 
        275                 280                 285             


Leu Gln Arg Ser Asp Ala Ile Glu Phe Gly Lys Asn Val Gly Leu Tyr 
    290                 295                 300                 


Thr Asp Ser Pro Phe Lys Leu Ser Asn Glu Glu Arg Asn Lys Leu Gln 
305                 310                 315                 320 


Leu Glu Glu Lys His Arg Ala Leu Glu Glu Gln Lys Ile Val Asp Lys 
                325                 330                 335     


Glu Gly Asp Gly His Lys Val Asn Pro Arg Ile Ile Ser Asn Thr Glu 
            340                 345                 350         


Ser Val Gln Asn Thr Ile Ile Gln Glu Met Leu Asp Val Tyr Arg Leu 
        355                 360                 365             


Arg Ile Pro Arg Glu Gly Arg Ile Asp Ala Met Met Asn Glu Gly Thr 
    370                 375                 380                 


Leu Ile Met Asp Ile Leu Asn Glu Leu Arg Arg Cys Pro Lys Ser Val 
385                 390                 395                 400 


Tyr Glu Thr Phe Ser Pro Ala Asp Lys Lys Lys Phe Asn Lys Val Gly 
                405                 410                 415     


Thr Asn Pro Asp Gly Ser Lys Ser Glu Met Lys Leu Ile Arg Tyr His 
            420                 425                 430         


Asp Arg Phe Pro Tyr Leu Ala Leu Arg Met Ile Asp Gln Thr Asn Ala 
        435                 440                 445             


Ile Gly Asp Ile Arg Phe His Leu Arg Leu Gly Leu Phe Arg Tyr Arg 
    450                 455                 460                 


Phe Tyr Asn Lys Lys Thr Ile Ser Gly Glu Leu Val Asn Pro Val Arg 
465                 470                 475                 480 


Thr Ile Gln Lys Glu Val Asn Gly Phe Gly Arg Trp Gln Asp Val Glu 
                485                 490                 495     


Glu Gly Arg Lys Ser Leu Tyr Gly Lys Tyr Phe Gln Asn Arg Ile Ile 
            500                 505                 510         


Asn Asp Asp Gly Leu Glu Gln Pro Val Pro Asp Ser Leu Gln Ser Leu 
        515                 520                 525             


Pro Tyr Ile Thr Asp Trp His Ala Ser Tyr Asn Ile His Ala Cys Arg 
    530                 535                 540                 


Ile Gly Met Ala Trp Asn Leu Ser Gln Met Glu Asp Ala Leu Tyr Leu 
545                 550                 555                 560 


Pro Pro Leu Thr Phe Asp Asp Gly Asn Asn Arg Asn Arg Lys Ala Pro 
                565                 570                 575     


Leu Asp Met Pro Ala Pro Met Cys Tyr Met Ser Ile Tyr Asp Ile Pro 
            580                 585                 590         


Ala Leu Leu Phe Tyr Asn Tyr Leu Tyr Lys Arg Tyr His Ala Glu Arg 
        595                 600                 605             


Tyr Thr Ser Ala Gly Ile Leu Thr Ala Glu Ser Ile Ile Lys Asn Lys 
    610                 615                 620                 


Tyr Asn Ala Leu Asn Val Phe Phe Glu Phe Val Thr Ser Gly Ala Asp 
625                 630                 635                 640 


Leu Asn Ser Ile Lys Lys Lys Gln Ile Asp Leu Gly Leu Ala Asp Asn 
                645                 650                 655     


Glu Leu Pro Asp Lys Ile Arg Cys Phe Ile Gly Thr Lys Lys Leu Phe 
            660                 665                 670         


Asn Ile Asp Gly Lys Pro Leu Leu Asp Lys Asn Thr Arg Glu Gln Leu 
        675                 680                 685             


Leu Lys Glu Trp Arg Pro Glu Ala Glu Leu Arg Arg His Thr Ile Asn 
    690                 695                 700                 


Arg Leu Lys Ala Ile Ile Glu Glu Asp Thr Tyr Arg Ile Glu Ser Leu 
705                 710                 715                 720 


Gly Lys Lys Arg Glu Lys Ile Glu Val Gly Gly Arg Asn Asn Arg Tyr 
                725                 730                 735     


Gly Arg Lys Gly Arg Ala Asp Ile Arg Pro Gly Ala Ile Ala Arg Tyr 
            740                 745                 750         


Ile Thr Lys Ser Leu Met Leu Trp Gln Pro Ala Met Pro Val Ala Gly 
        755                 760                 765             


Gly Gly Lys Leu Thr Ser Ala Asn His Gln Ala Leu Ala Lys Tyr Leu 
    770                 775                 780                 


Glu Glu Tyr Gly Ser Asn Asp Glu Ser Leu Asn Asn Leu His Ser Ile 
785                 790                 795                 800 


Phe Gln Arg Ala Gly Leu Ile Gly Gly Thr His Pro His Pro Phe Ile 
                805                 810                 815     


Asn Lys Val Leu Lys Gln Lys Pro Met Ser Ile Leu Gln Leu Tyr Thr 
            820                 825                 830         


Phe Tyr Leu Glu Val Glu Lys Ala Tyr Ala Glu Arg Met Leu Ala Glu 
        835                 840                 845             


Val Lys Thr Asn Thr Asp Asp Ile Thr Leu Pro Pro Phe Ala His Pro 
    850                 855                 860                 


Asn Gly Leu Arg Trp Ser Thr Thr Leu Thr Glu Ala Ala Lys Arg Tyr 
865                 870                 875                 880 


Thr Thr Val Pro Asn Glu Gln Asn Asp Ala Ser Thr Asp Ser His Arg 
                885                 890                 895     


Ala Val Met Ser Leu Pro Asp Gly Leu Phe Thr Ser His Ile Ile Ser 
            900                 905                 910         


Leu Leu Arg Gln Ala Leu Pro His Asn Ser Glu Leu Glu Pro Met Arg 
        915                 920                 925             


Lys Ile Leu Glu Gly Asn Asn Asn Met Leu Gly Ala Ala Tyr Ile Ile 
    930                 935                 940                 


Arg Phe Trp Phe Asp Gln Val Glu Gly Asp Ala Pro Gln Ala Phe Tyr 
945                 950                 955                 960 


Asn Asn Asp Gly Asp Gln Tyr Arg Arg Phe Tyr Lys Thr Leu Ser Leu 
                965                 970                 975     


Leu Asn Pro His Arg Met Lys Asn Arg Gln Leu Ile Pro Asp Tyr Phe 
            980                 985                 990         


Ser Glu Ser Glu Ile Lys Glu Leu  Leu Gln Ile Met Lys  Lys Lys Asn 
        995                 1000                 1005             


Arg Asp  Gln Leu Arg Ser Ala  Val Met Lys Ala Tyr  Gly Leu Lys 
    1010                 1015                 1020             


Glu Asn  Lys Ala Glu Asp Ile  Lys Gln Arg Gln Asn  Ala Phe Leu 
    1025                 1030                 1035             


Glu Met  Leu His Asp Val Ser  Asp Ser Glu Gln Ala  Leu His Arg 
    1040                 1045                 1050             


Tyr Arg  Ile Gln Asp Ile Cys  Leu Phe Leu Ser Gly  Arg Ser Phe 
    1055                 1060                 1065             


Leu Val  Asp Ile Leu Thr Lys  Ser Met Gly Gly Asn  Ile Glu Lys 
    1070                 1075                 1080             


Lys Thr  Leu Glu Lys Ala Lys  Glu Met His Leu Arg  Asp Phe Gly 
    1085                 1090                 1095             


Phe Asp  Asn Glu Phe Glu Phe  Leu Asp Asn Ala Lys  Ile Pro Tyr 
    1100                 1105                 1110             


Val Phe  Lys Ile Gly Asn Met  Thr Ile Ser Met Pro  Ala Met Ser 
    1115                 1120                 1125             


Phe Lys  Asn Tyr Gly Thr Ile  Phe Arg Leu Leu Gly  Asp Glu Arg 
    1130                 1135                 1140             


Leu Lys  Gln Leu Leu Glu Gly  Leu Ser Ala Met Asn  Ile Tyr Glu 
    1145                 1150                 1155             


Val Thr  Phe Asn Asp Leu Thr  Thr Glu Phe Ala Ser  Tyr Asp Gln 
    1160                 1165                 1170             


Lys Arg  Ile Glu Val Met Lys  Leu Ala Gln Asp Ile  Glu Gln Met 
    1175                 1180                 1185             


Ala Ile  Ala Gly Asn Ile Tyr  Leu Asn Asp Pro Asp  Asp Pro Arg 
    1190                 1195                 1200             


Phe Tyr  Val Lys Asp Lys Asp  Gly Asn Ser Thr Asn  Leu Ala Met 
    1205                 1210                 1215             


Arg Asn  Asn Phe Asn Ser Leu  Val His Leu Leu Ser  His Tyr Phe 
    1220                 1225                 1230             


Glu Phe  Ala Asp Phe Phe Thr  Glu Leu Arg Asn Thr  Ile Ala His 
    1235                 1240                 1245             


Asn Arg  Tyr Pro Lys Lys Tyr  Lys Asp Ala Glu Asp  Lys Asn Arg 
    1250                 1255                 1260             


Asn Pro  Tyr Ser Glu Asp Leu  Pro Ala Ala Gly Tyr  Glu Gly Val 
    1265                 1270                 1275             


Leu Pro  Pro Asn Ile Phe Ala  Ser Met Lys Gln Ile  Leu Glu Asp 
    1280                 1285                 1290             


Lys Val  Ser Glu Lys Thr Asn  
    1295                 1300 


<210>  1385
<211>  1310
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1385

Met Gly Lys Asp Tyr Lys Thr Gln Gln Pro Lys Lys Val Arg Arg Gln 
1               5                   10                  15      


Gln Lys Thr Asn Phe Ser Ile Asn Leu Thr Gly Lys His Val Phe Gly 
            20                  25                  30          


Ala Tyr Phe Asn Met Ala Arg Thr Asn Phe Val Lys Thr Ile Asn Tyr 
        35                  40                  45              


Ile Met Pro Ile Ala Gly Val Arg Gly Ser Tyr Ser Glu Asn Gln Ile 
    50                  55                  60                  


Asn Lys Met Leu His Ala Leu Phe Leu Ile Gln Ala Gly Arg Ser Gly 
65                  70                  75                  80  


Glu Leu Thr Asn Glu Gln Arg Gln Trp Glu Lys Lys Leu Arg Leu Asn 
                85                  90                  95      


Thr Glu Gln Gln Thr Arg Leu Gln Lys Leu Leu Phe Lys His Phe Pro 
            100                 105                 110         


Val Leu Gly Pro Met Met Ala Asp Val Ala Asp His Lys Ala Phe Leu 
        115                 120                 125             


Asn Lys Lys Lys Ser Lys Val Gln Thr Glu Glu Asp Lys Phe Ala Gln 
    130                 135                 140                 


Leu Lys Gly Val Ser Leu Ala Asp Cys Leu Asp Val Ile Cys Leu Met 
145                 150                 155                 160 


Ala Asp Ala Leu Thr Glu Cys Arg Asn Phe Tyr Thr His Lys Ala Pro 
                165                 170                 175     


Tyr Asn Ala Pro Ser Gln Leu Ala Ala Gln Tyr Gln His Gln Glu Met 
            180                 185                 190         


Ile Ala Lys Lys Leu Asp Lys Val Val Val Ala Cys Arg Arg Val Leu 
        195                 200                 205             


Lys Asp Arg Glu Gly Leu Ser Val Asn Glu Val Glu Phe Leu Thr Gly 
    210                 215                 220                 


Ile Asp His Leu His Gln Glu Val Val Lys Asp Glu Ser Gly Asn Val 
225                 230                 235                 240 


Lys Lys Lys Asn Gly Lys Val Met Lys Thr Phe Val Glu Tyr Asp Asp 
                245                 250                 255     


Phe Tyr Phe Lys Ile Ser Gly Lys Arg Leu Val Lys Gly Phe Thr Val 
            260                 265                 270         


Ala Val Lys Asp Asp Lys Pro Val Asn Ile Asp Thr Met Leu Pro Ala 
        275                 280                 285             


Leu Ser Asp Phe Gly Leu Leu Tyr Phe Cys Val Leu Phe Leu Ser Lys 
    290                 295                 300                 


Pro Tyr Ala Lys Leu Phe Ile Asp Glu Val Arg Leu Phe Glu Phe Ser 
305                 310                 315                 320 


Pro Phe Thr Asp Thr Glu Asn Met Ile Met Ser Glu Met Leu Ser Ile 
                325                 330                 335     


Tyr Arg Ile Arg Thr Pro Arg Leu His Lys Ile Asp Ser Arg Asp Asn 
            340                 345                 350         


Lys Ala Thr Leu Ala Met Asp Ile Phe Gly Glu Leu Arg Arg Cys Pro 
        355                 360                 365             


Ile Glu Leu Tyr Glu Leu Leu Asp Lys Asn Met Gly Gln Pro Phe Phe 
    370                 375                 380                 


His Asp Glu Val Lys His Pro Asn Ser His Thr Pro Glu Val Ser Lys 
385                 390                 395                 400 


Arg Leu Arg Tyr Asn Asp Arg Phe Pro Thr Leu Ala Leu Arg Tyr Ile 
                405                 410                 415     


Asp Glu Asn Glu Leu Phe Lys His Ile Arg Phe Gln Leu Gln Leu Gly 
            420                 425                 430         


Ala Phe Arg Tyr Arg Phe Tyr Asp Lys Glu Asp Cys Ile Asp Gly Ile 
        435                 440                 445             


Val Arg Val Arg Arg Ile Gln Lys Asp Ile Asn Gly Tyr Gly Arg Leu 
    450                 455                 460                 


Gln Glu Val Ala Asp Lys Arg Ile Glu Lys Trp Gly Asp Leu Ile Gln 
465                 470                 475                 480 


Lys Arg Glu Glu His Ala Val Lys Leu Glu His Glu Glu Leu Tyr Ile 
                485                 490                 495     


Asp Leu Asp Gln Phe Val Glu Asp Thr Ala Asp Ser Thr Pro Tyr Val 
            500                 505                 510         


Thr Asp Arg Arg Pro Ser Tyr Asn Ile His Ala Asn Arg Ile Gly Leu 
        515                 520                 525             


Tyr Trp Glu Asp Ser Gln Asn Pro Lys Ser Tyr Lys Ile Phe Asp Glu 
    530                 535                 540                 


Asn Gly Met Tyr Ile Pro Glu Leu Val Val Thr Glu Asp Glu Lys Ala 
545                 550                 555                 560 


Pro Ile Lys Met Pro Ala Pro Arg Cys Thr Leu Ser Val Tyr Asp Leu 
                565                 570                 575     


Ser Ala Met Leu Phe Tyr Glu Tyr Leu His Glu Gln Gln Asp Val Asp 
            580                 585                 590         


Thr Pro Ser Ala Glu Arg Ile Ile Ile Asp Cys Glu Asp Asp Tyr Arg 
        595                 600                 605             


Arg Phe Phe Lys Ala Val Ala Glu Gly Thr Leu Thr Pro Phe Lys Lys 
    610                 615                 620                 


Thr Lys Glu Phe Arg Glu Tyr Leu Glu Arg Glu Tyr Pro Lys Leu Arg 
625                 630                 635                 640 


Met Ala Asp Ile Pro Glu Lys Leu Gln Leu Tyr Leu Thr Ser Lys Gly 
                645                 650                 655     


Leu Thr His Asp Asn Lys Pro Glu Thr Val His Glu Arg Met Ile Arg 
            660                 665                 670         


Leu Thr Arg Glu His Leu Glu Glu Arg Glu Ile His Val Gln Arg Arg 
        675                 680                 685             


Leu Glu His Tyr Gln Glu Asp Arg Lys Met Ile Gly Glu Lys Glu Asn 
    690                 695                 700                 


Lys Tyr Gly Lys Lys Ser Phe Ala Asp Val Arg His Gly Ala Leu Ala 
705                 710                 715                 720 


Arg Tyr Leu Ala Gln Ser Met Met Glu Trp Gln Pro Thr Lys Leu Lys 
                725                 730                 735     


Asp Lys Glu Lys Gly His Asp Lys Leu Thr Gly Leu Asn Tyr Asn Val 
            740                 745                 750         


Leu Thr Ala Tyr Leu Ala Thr Tyr Gly His Pro Gln Val Ser Glu Glu 
        755                 760                 765             


Asp Phe Val Ser Leu Thr Leu Glu Gln Val Leu Thr Asn Ala His Leu 
    770                 775                 780                 


Leu Gly Gly Asn Asn Pro His Pro Phe Ile Gly Lys Val Leu Ala Leu 
785                 790                 795                 800 


Gly Asn Arg Asn Ile Glu Glu Leu Tyr Leu His Tyr Leu Glu Glu Glu 
                805                 810                 815     


Leu Lys His Ile Arg Ser Arg Lys Gln Ser Leu Leu Ser Asn Pro Ser 
            820                 825                 830         


Asp Lys Ala Leu Ser Ala Leu Pro Phe Val His Tyr Asp Arg Val Arg 
        835                 840                 845             


Phe His Glu Arg Thr Asp Glu Glu Met Arg Ala Leu Ala Ala Arg Tyr 
    850                 855                 860                 


Thr Thr Ile Gln Leu Pro Asp Gly Leu Phe Thr Pro Tyr Ile Leu Glu 
865                 870                 875                 880 


Ile Leu Lys Lys His Tyr Thr Glu Asn Thr Glu Leu Gln Asn Ala Leu 
                885                 890                 895     


Arg Gln Asp Ala Thr Ala Lys Ile Asn Pro Thr Asn Asn Ala Ala Tyr 
            900                 905                 910         


Leu Ile Thr Leu Phe Tyr Lys Thr Val Leu Lys Asp Asp Ala Gln Pro 
        915                 920                 925             


Phe Tyr Ile Ser Gly Lys Ala Tyr Thr Arg Asn Lys Asp Gly Glu Lys 
    930                 935                 940                 


Ala Glu Ala Phe Ser Phe Lys Arg Ser Tyr Glu Leu Phe Ser Val Leu 
945                 950                 955                 960 


Asn Asn Asn Lys Lys Lys Thr Phe Pro Tyr Glu Leu Leu Pro Leu Phe 
                965                 970                 975     


Leu Thr Ser Asp Glu Ile Gln Glu Arg Leu Ser Ala Lys Leu Leu Asp 
            980                 985                 990         


Asp Asn Gly Asn Pro Ile Pro Glu  Ala Gly Lys Arg Gly  Lys Pro Ala 
        995                 1000                 1005             


Thr Asp  Ile Gln Gly Asn Thr  Ile Trp Gln Arg Gln  Ile Lys Gln 
    1010                 1015                 1020             


Lys Ile  Asn Gly Tyr Val Asn  Ser Leu Ser Asp Lys  Asp Leu Lys 
    1025                 1030                 1035             


Ile Ser  Met Asn Gln Ser Trp  Lys Lys Lys Glu Glu  Glu Arg Ala 
    1040                 1045                 1050             


Ala Lys  Arg Glu Ala Met Gln  Ser Arg Leu Thr Lys  Gln Ile Asn 
    1055                 1060                 1065             


Glu Val  Lys Gly Asn Glu Arg  Thr Leu Arg Arg Tyr  Lys Thr Gln 
    1070                 1075                 1080             


Asp Met  Val Leu Phe Leu Met  Ala Lys Glu Leu Phe  Ala Thr Ile 
    1085                 1090                 1095             


Ile Ser  Asp Gln Gly Asn Glu  Val Asn Trp Lys Gln  Met Arg Leu 
    1100                 1105                 1110             


Ser Lys  Val Cys Asn Glu Ala  Phe Leu Arg Gln Thr  Leu Thr Ile 
    1115                 1120                 1125             


Arg Val  Pro Val Thr Val Gly  Asn Thr Thr Ile Tyr  Val Glu Gln 
    1130                 1135                 1140             


Glu Asn  Met Ser Leu Lys Asn  Tyr Gly Glu Phe Tyr  Arg Phe Leu 
    1145                 1150                 1155             


Thr Asp  Asp Arg Leu Met Ser  Leu Leu Asn Ile Ile  Val Glu Thr 
    1160                 1165                 1170             


Leu Lys  Pro Asn Glu Asp Gly  Glu Leu Val Ile Arg  His Thr Asp 
    1175                 1180                 1185             


Leu Met  Ser Glu Leu Ala Ser  Tyr Asp Gln Tyr Arg  Ser Thr Ile 
    1190                 1195                 1200             


Phe Lys  Leu Ile Gln Asn Ile  Glu Asn Leu Ile Ile  Lys Glu Asn 
    1205                 1210                 1215             


Ala Ala  Leu Asn Asp Pro Asp  Ala Asp Gly Phe Trp  Val Arg Lys 
    1220                 1225                 1230             


Asp Leu  Pro Lys Arg Asn Asn  Phe Ala Ser Leu Leu  Glu Leu Leu 
    1235                 1240                 1245             


Asn Gln  Leu Asn Asn Val Asp  Leu Thr Asp Asp Glu  Arg Lys Leu 
    1250                 1255                 1260             


Leu Val  Ala Ile Arg Asn Ala  Phe Ser His Asn Ser  Tyr Asn Ile 
    1265                 1270                 1275             


Asp Phe  Ser Leu Ile Arg Asp  Val Lys His Leu Pro  Glu Val Ala 
    1280                 1285                 1290             


Lys Gly  Ile Leu Gln His Leu  Gln Ser Val Leu Gly  Val Glu Gln 
    1295                 1300                 1305             


Thr Lys  
    1310 


<210>  1386
<211>  1113
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1386

Met Glu Ser Leu Ile Gln Gln Glu Glu Asn Lys Ala Arg Asn Leu Ile 
1               5                   10                  15      


Asp Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg His Asn 
            20                  25                  30          


Ile Phe Ser Ile Asn Asn His Leu Ala Ser Tyr Phe Gly Thr Ser Gly 
        35                  40                  45              


Leu Ser Asn Glu Glu Gln Ile Pro Asp Ser Phe Leu Leu Ser Ala Asp 
    50                  55                  60                  


Lys Arg Arg Asn Gln Glu Thr Lys Glu Leu Ile Lys Glu Asn Leu Leu 
65                  70                  75                  80  


Phe Glu Arg Thr Leu Arg Phe Met Pro Ile Phe Arg Ile Phe Asp Thr 
                85                  90                  95      


Glu Arg Leu Pro Lys Glu Val Arg Leu Asn Thr Glu Asn Met Glu Lys 
            100                 105                 110         


Asp Phe Asp Glu Met Arg Lys Cys Leu Lys Gln Val Phe Ser Glu Leu 
        115                 120                 125             


Asn Ile Phe Arg Asn Asp Tyr Thr His Tyr Phe Ser Thr Asn Thr Glu 
    130                 135                 140                 


Thr Thr Arg Lys Leu Gln Val Thr Pro Glu Leu Glu Glu Phe Leu Ser 
145                 150                 155                 160 


Arg Ser Phe Lys Leu Ala Ile Ala Phe Thr Lys Gln Arg Met Arg Asp 
                165                 170                 175     


Val Leu Lys Glu Glu Asp Tyr Ser Leu Val Glu Lys Lys Val Met Val 
            180                 185                 190         


Leu Pro Glu Glu Arg Val Ile Thr Thr Glu Gly Ile Val Phe Leu Ala 
        195                 200                 205             


Cys Met Phe Leu Glu Arg Glu Tyr Ala Phe Gln Phe Ile Gly Lys Val 
    210                 215                 220                 


Val Gly Leu Lys Gly Thr His Arg Asn Glu Phe Ile Ala Thr Arg Glu 
225                 230                 235                 240 


Val Leu Met Ala Tyr Cys Val Lys Leu Pro His Asp Lys Phe Ile Ser 
                245                 250                 255     


Glu Asp Ser Lys Gln Ala Leu Ile Leu Asp Ile Ala Asn Glu Leu Asn 
            260                 265                 270         


Lys Cys Pro Leu Thr Leu Tyr Asp Val Ile Thr Glu Asp Gly Arg Lys 
        275                 280                 285             


Gln Phe Arg Pro Glu Leu Thr Asp Asp Ala Lys Lys Ser Val Ile Glu 
    290                 295                 300                 


Asn Cys Ile Asn Glu Asp Leu Glu Val Asp Tyr Asp Glu Tyr Ile Gln 
305                 310                 315                 320 


Ile Leu Thr Lys Lys Val Arg Tyr Lys Asn Arg Phe Pro Tyr Phe Ala 
                325                 330                 335     


Phe Gln Tyr Ile Glu Glu Thr Lys Leu Leu Asp Asn Phe Arg Phe Ser 
            340                 345                 350         


Ile Asp Leu Gly Gln Phe Val Leu Ala Glu Tyr Glu Lys Arg Met Ala 
        355                 360                 365             


Gly Glu Pro Thr Ser Arg Ile Val Val Glu Asn Val Lys Ala Phe Lys 
    370                 375                 380                 


Tyr Leu Lys Glu Val Thr Asp Glu Asp Val Val Leu Gly Leu Met Lys 
385                 390                 395                 400 


Ser Asn Pro Pro Ser Asn Arg Phe Leu Gln Phe Ser Pro His Tyr Asn 
                405                 410                 415     


Ser Asp Asn Asn Lys Ile Gly Ile Ser Ser Lys Pro Gln Thr Ser Val 
            420                 425                 430         


Val Lys Ser Lys Gly Lys Ile Asp Ser Lys Ile Glu Tyr Lys Ile Lys 
        435                 440                 445             


Gln Pro Leu Pro Arg Ala Phe Val Ser Ile His Glu Leu Pro Lys Ile 
    450                 455                 460                 


Ile Leu Leu Asp Tyr Leu Ser Lys Gly Ser Val Val Lys Ile Ile Asn 
465                 470                 475                 480 


Ser Phe Ile Arg Thr Asn Lys Ser Ile Ile Leu Asp Val Asp Lys Ile 
                485                 490                 495     


Lys Glu Ile Lys Glu Lys Leu Pro Asn Asn Glu Val Trp Phe Pro Phe 
            500                 505                 510         


Arg Arg Met Thr Asp Ser Lys Lys His Ser Ala Tyr Ser Glu Lys Gln 
        515                 520                 525             


Lys Ala Glu Ile Leu Arg Arg Lys Lys Leu Leu Asn Glu Ile Leu Ser 
    530                 535                 540                 


Ser Tyr Ser Leu Asn Ile Lys Gln Ile Pro Ser Arg Ile Ile Asp Tyr 
545                 550                 555                 560 


Trp Leu Asn Ile Ile Asp Val Arg Lys Glu Arg Ser Phe Ser Asp Arg 
                565                 570                 575     


Ile Lys Leu Met Lys Arg Asp Cys Ala Asp Arg Tyr Lys Ala Val Lys 
            580                 585                 590         


Arg Asn Glu Lys Asp Lys Thr Val Ala Ile Pro Lys Ile Gly Glu Met 
        595                 600                 605             


Ala Thr Phe Leu Ala Lys Asp Ile Val Ala Met Ile Val Asp Glu Asp 
    610                 615                 620                 


Lys Lys Ser Lys Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys 
625                 630                 635                 640 


Leu Ala Leu Tyr Ala Asn Ile Glu Lys Lys Asn Leu Phe Ile His Leu 
                645                 650                 655     


Val Thr Asn Glu Leu Lys Leu Asn Glu Lys Gly Gly His Pro Phe Leu 
            660                 665                 670         


Lys Arg Ile Asn Leu Asn Ser Ile Thr Arg Thr Lys Glu Leu Tyr Glu 
        675                 680                 685             


Ile Tyr Leu Ser Glu Lys Ala Tyr Lys Leu Asn Ser Lys Glu Asn Asp 
    690                 695                 700                 


Glu Ser Trp Met Ser Met Thr Phe Tyr His Leu Glu Trp Asn Glu Lys 
705                 710                 715                 720 


Ala Lys Lys Lys Met Thr Lys Val Val Tyr Pro Val Asn Asp Glu Gln 
                725                 730                 735     


Ile Pro Tyr Thr Ile Lys Gln Trp Asn Lys Pro Gln Gln Pro Leu Phe 
            740                 745                 750         


Asp Arg Phe Thr Asn Glu Gln Gly Lys Ser Ser Asp Trp Val Arg Leu 
        755                 760                 765             


Lys Pro Leu Asp Leu Pro Thr Asn Leu Phe Asp Glu Glu Ile Cys Val 
    770                 775                 780                 


Gln Leu Arg Ser Arg Leu Gln Glu Ala Lys Ile Pro Phe Asp Asn Ile 
785                 790                 795                 800 


Ser Asn Tyr Ser Glu Leu Leu Lys Leu Trp Trp Lys Ser Arg Asp Asp 
                805                 810                 815     


Ser Thr Gln Pro Phe Tyr Leu Leu Glu Arg Gln Tyr Asn Ile Tyr Asp 
            820                 825                 830         


Glu Ser Val Arg Phe Thr Leu Asn Ser Lys Asn Lys Phe Lys Asp Tyr 
        835                 840                 845             


Tyr Gln Ala Ala Leu Lys Lys Val Phe Asn Gln Lys Lys Ala Glu Arg 
    850                 855                 860                 


Glu Ala Lys Arg Arg Phe Asn Lys Arg Leu Pro Asp Ile Gln Phe Lys 
865                 870                 875                 880 


Asp Val Glu Arg Val Phe Lys His Ala Ile Ala Glu Thr Glu Lys Gln 
                885                 890                 895     


Ile Arg Ile Ile Gln Glu Glu Asp Arg Ile Met Leu Leu Met Leu Glu 
            900                 905                 910         


Lys Leu Met Asp Asp Gln Gln Leu Lys Leu Gly Lys Ala Glu Thr Leu 
        915                 920                 925             


Leu Ser Ser Thr Val Pro Val Lys Gln Lys Ile Gly Asp Lys Thr Asn 
    930                 935                 940                 


Ser Ser Arg Val Ile Val Ala Gln Arg Lys Gln Lys His Tyr Thr Val 
945                 950                 955                 960 


Leu Arg Lys Tyr Gln Tyr Asp Arg Arg Leu Pro Glu Leu Phe Lys Tyr 
                965                 970                 975     


Thr Thr Glu Lys Glu Glu Leu Lys Leu Glu Trp Leu Glu Asp Glu Leu 
            980                 985                 990         


Lys Ala Tyr Asn Lys Gly Lys Leu  Lys Val Phe Asp Leu  Val Phe Ser 
        995                 1000                 1005             


Leu Glu  Lys Arg Ile Ile Glu  Val Ala Lys Gln Asp  Ile Ile Ala 
    1010                 1015                 1020             


Leu Leu  Asp Lys Ser Gly Ser  Asn Asp Ser Lys Phe  Asn Val Asp 
    1025                 1030                 1035             


His Lys  Pro Tyr Ile Lys Trp  Leu Glu Asn Met Glu  Leu Ile Asn 
    1040                 1045                 1050             


Ser Lys  Glu Ala Gly Phe Met  Lys Lys Ile Arg Asn  Ser Phe Ser 
    1055                 1060                 1065             


His Asn  Gln Phe Pro Glu Cys  Gln Thr Val Glu Leu  Met Ile Ser 
    1070                 1075                 1080             


Leu Lys  Ser Asp Ile Pro Ile  Ala Thr Gln Ile Val  Asn Glu Tyr 
    1085                 1090                 1095             


Glu Arg  Leu Ile Leu Arg Ile  Ser Ser Gln Ile Glu  Lys Met Lys 
    1100                 1105                 1110             


<210>  1387
<211>  1133
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1387

Met Glu Lys Glu Leu Ile Val Asn Glu Asn Arg Glu Arg Thr Leu Lys 
1               5                   10                  15      


Asp Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Ile Ala Lys Arg Phe Gly Phe Thr Ile 
        35                  40                  45              


Leu Pro Asn Glu Glu Arg Ile Ser Ser Ser Phe Leu Cys Asn Lys Ala 
    50                  55                  60                  


Leu Lys Asn Ala Asp Trp Asn His Ile His Ser Arg Thr Lys Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Ile Lys Val Phe Asp Ala Glu Ser Leu Pro Lys Thr Glu 
                85                  90                  95      


Tyr Asp Phe Leu Met Trp Glu Gly Lys Asn Phe Ala Leu Met Thr Asp 
            100                 105                 110         


Thr Leu Lys Ser Val Phe Ser Glu Ile Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Phe Tyr Ser Thr Glu Lys Gly Thr Ile Arg Lys Thr Lys Ile 
    130                 135                 140                 


Ser Pro Gln Leu Ala Ser Phe Leu Glu Val Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Glu Tyr Ser Lys Ile Arg Leu Lys Asp Val Leu Arg Glu Glu Asp Phe 
                165                 170                 175     


Asn Leu Val Glu Arg Leu Lys Val Cys Asn Asn Gly Ser Glu Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Cys Met Phe Leu Glu Arg Glu His 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Val Lys Gly Leu Lys Gly Thr Gln Tyr 
    210                 215                 220                 


Pro Ser Phe Ile Ala Thr Arg Glu Thr Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asp Pro Lys Gln Ser Leu Ile 
                245                 250                 255     


Leu Asp Ile Val Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Glu 
            260                 265                 270         


Ile Ile Ser Glu Glu Asp Arg Lys Gln Phe Arg Pro Glu Leu Asp Ile 
        275                 280                 285             


Lys Ser Val Asp Asn Leu Leu Lys Asn Ser Gly Lys Glu Glu Leu Leu 
    290                 295                 300                 


Asp Thr Met Glu Phe Glu Glu Tyr Met Glu Ser Leu Thr Lys Arg Val 
305                 310                 315                 320 


Arg His Ser Asn Arg Phe Pro Tyr Phe Ala Leu Arg Phe Ile Glu Glu 
                325                 330                 335     


Met Lys Leu Leu Asn Asn Met Gln Leu His Ile His Leu Gly Lys Phe 
            340                 345                 350         


Glu Leu Gln Lys Tyr Asp Lys Gln Leu Asn Asn Glu Pro Phe Glu Arg 
        355                 360                 365             


Ala Ile Ile Glu Asp Ala Lys Ala Phe Gly Tyr Leu Lys Asp Phe Asn 
    370                 375                 380                 


Asp Glu Asn Asp Ile Lys Gly Glu Ile Val Ser Gly Lys Asp Ser Glu 
385                 390                 395                 400 


Gly Phe Ala Gln Phe Ser Pro Ser Tyr Phe Leu Lys Tyr Asn Lys Ile 
                405                 410                 415     


Gly Ile Arg Tyr Lys Arg Asp Ile Pro His Leu Ile Val Asp Lys Asn 
            420                 425                 430         


Asn Ser Lys Gly Ala Tyr Asn Leu Lys Gln Pro Leu Ala Lys Ala Phe 
        435                 440                 445             


Leu Ser Ala Tyr Glu Leu Pro Lys Ile Ile Leu Met Glu Tyr Leu Gln 
    450                 455                 460                 


Lys Gly Arg Ala Gly Glu Leu Ile Asp Asp Phe Ile Gln Leu Asn Asp 
465                 470                 475                 480 


Asn Lys Ile Met Thr Trp Asp Phe Ile Glu Asn Ile Lys Ser Gln Leu 
                485                 490                 495     


Pro Asp Trp Lys Thr Phe Asn Lys Lys Ser Phe Gly Leu Lys Asp Lys 
            500                 505                 510         


Lys Gly Tyr Gln Thr Glu Glu Leu Lys Glu Leu Asn Thr Arg Lys Asn 
        515                 520                 525             


Gln Leu Asn Lys Leu Leu Ala Pro Glu Gly Leu Asn His Asn Arg Ile 
    530                 535                 540                 


Pro Glu Arg Ile Thr Asp Tyr Trp Leu Asn Ile Gly Asp Val Lys Lys 
545                 550                 555                 560 


Lys Arg Ser Phe Ser Asp His Ile Lys Leu Met Lys Arg Glu Gly Met 
                565                 570                 575     


Glu Arg Leu Lys Gln Leu Glu Lys Phe Lys Lys Glu Gly Lys Gly Lys 
            580                 585                 590         


Ile Pro Lys Val Gly Glu Met Ala Thr Phe Leu Ala Ser Asp Ile Val 
        595                 600                 605             


Asn Met Val Ile Asn Glu Glu Arg Lys Asn Lys Ile Thr Ser Phe Tyr 
    610                 615                 620                 


Tyr Asp Lys Met Gln Gln Cys Leu Ala Leu Tyr Ala Asp Ser Glu Lys 
625                 630                 635                 640 


Lys Ala Leu Phe Ile Gln Ile Ile Lys Glu Leu Lys Leu Asn Glu Glu 
                645                 650                 655     


Gly Gly His Pro Phe Leu Lys Lys Ile Asp Leu Gln Lys Ile Ser Lys 
            660                 665                 670         


Thr Ser Gln Leu Tyr Glu Leu Tyr Leu Thr Glu Lys Val Asn Lys Pro 
        675                 680                 685             


Ile Arg Glu Glu Val Phe Lys Tyr Asp Arg Lys Lys Gly Tyr Lys Val 
    690                 695                 700                 


Thr Lys Ile Ile Leu Arg Asp Lys Ser Trp Met Gly Glu Met Phe Tyr 
705                 710                 715                 720 


Thr Thr Glu Lys Ser Glu Lys Thr Gly Lys Asp Ile Thr Ile Val Arg 
                725                 730                 735     


Met Pro Glu Asn Lys Thr Glu Ile Pro Phe Thr Ile Arg Arg Trp Glu 
            740                 745                 750         


Glu Lys Gln Lys Thr Asp Leu Lys Val Trp Phe His Asn Val Thr Lys 
        755                 760                 765             


Gly Lys Asp Lys Thr Lys Asp Gly Pro Lys Ala Ile Ser Leu Pro Thr 
    770                 775                 780                 


Asp Ile Phe Asp Asp Glu Ile Cys Thr Leu Ile Lys Ile Gln Leu Asp 
785                 790                 795                 800 


Lys Ile Asn Val Lys Tyr Lys Glu Asn Leu Lys Tyr Asn Glu Leu Leu 
                805                 810                 815     


Lys Leu Trp Trp Trp Lys Ser Arg Glu Asp Asp Val Gln Asn Phe Tyr 
            820                 825                 830         


His Ser Lys Arg Leu Tyr Lys Val Tyr Asp Glu Glu Ile Asn Phe Thr 
        835                 840                 845             


Pro Asp Thr Lys Ser Thr Phe Val Glu Tyr Tyr Glu Lys Ala Leu Asn 
    850                 855                 860                 


Ser Ala Phe Glu Lys Leu Ser Lys Ala Arg Lys Lys Glu Arg Lys Thr 
865                 870                 875                 880 


His Arg Ala Leu Pro Asp Ile Asn Lys Lys Glu Val Glu Lys Val Phe 
                885                 890                 895     


Lys Arg Ala Ile Gly Glu Thr Glu Lys Asp Ile Arg Ile Leu Gln Glu 
            900                 905                 910         


Glu Asp Arg Ile Ser Ile Leu Met Leu Glu Met Leu Met Asp Asn Ala 
        915                 920                 925             


Thr Leu Lys Leu Lys Asn Ile Ser Tyr Leu Leu Asn Asp Thr Thr Arg 
    930                 935                 940                 


Ile Gln Gln Ser Ile Thr Ala His Leu Ser Phe Asp Glu Asn Gly Glu 
945                 950                 955                 960 


Ser Ile Lys Glu Gly Thr Lys Pro Thr Ile Thr Lys Thr Ile Ile Ala 
                965                 970                 975     


Asp Arg Lys Gln Lys Asn Tyr Thr Val Leu Arg Lys Phe Ile Phe Asp 
            980                 985                 990         


Arg Arg Met Pro Glu Leu Phe Glu  Tyr Tyr Ala Ser Asn  Glu Val Ala 
        995                 1000                 1005             


Leu Asp  Trp Val Thr Asp Glu  Leu Arg Ala Tyr Asn  Thr Ala Lys 
    1010                 1015                 1020             


Gln Tyr  Val Phe Asp Asn Val  Phe Asn Leu Glu Gln  Lys Leu Ile 
    1025                 1030                 1035             


Glu Lys  Asp Glu Thr Gly Ile  Lys Ala Met Tyr Thr  Asn Lys Glu 
    1040                 1045                 1050             


Gly Thr  Pro Ile Thr Gly Asn  Ile Gln Tyr Lys Pro  Tyr Val Arg 
    1055                 1060                 1065             


Trp Leu  Glu Asn Lys Gly Leu  Ile Asn Lys Asn Gln  Lys Arg Phe 
    1070                 1075                 1080             


Leu Thr  Met Thr Arg Asn Cys  Phe Ala His Asn Gln  Phe Pro Gln 
    1085                 1090                 1095             


Lys Lys  Thr Val Leu Arg Ile  Val Pro Asn Leu Thr  Asp Asn Asn 
    1100                 1105                 1110             


Ile Ala  Leu Gln Ile Ala Asp  Ala Tyr Lys Asn Ile  Thr Asp Glu 
    1115                 1120                 1125             


Ile Leu  Thr Lys Leu 
    1130             


<210>  1388
<211>  1081
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1388

Met Gln Ala Gln Ser Leu Phe Asp Glu Tyr Lys His Leu Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Val Met Ser Ile Met Asn Ile Ile Thr Val Leu Asn His Ile 
            20                  25                  30          


His Gln Ile Ala Gly Leu Lys Arg Asn Glu Leu Gly Asp Asp Asp Asn 
        35                  40                  45              


Ile Tyr Ser His Pro Val Leu Lys Tyr Ile Ala Pro Glu Asn Asn Ser 
    50                  55                  60                  


Thr Thr Leu Pro Glu Lys Arg Asp Leu Ile Lys Glu Leu Leu Leu Glu 
65                  70                  75                  80  


Tyr Leu Pro Phe Leu Glu Ala Met Lys Asp Cys Tyr Lys Glu Val Lys 
                85                  90                  95      


Val Glu Lys Asp Lys Arg Asn Asn Lys Tyr Val Lys Asp Lys Lys Gln 
            100                 105                 110         


Val Phe Ile Arg Asn Tyr Ser Asp Ile Tyr Cys Ile Tyr Trp Thr Leu 
        115                 120                 125             


Tyr Asn Ile Phe Ser Thr Leu Ile Asn Tyr Arg Asp Lys Ser Cys His 
    130                 135                 140                 


Tyr Arg Phe Ile Pro Ser Lys Asp Gln Glu Glu Tyr Ser Lys Arg Thr 
145                 150                 155                 160 


Glu Tyr Asp Thr Val Arg Ile Ile Asn Lys Tyr Tyr Thr Tyr Ala Leu 
                165                 170                 175     


Arg Lys Thr Lys Glu Lys Tyr Gly Tyr Thr Thr Glu Gln Leu Ser Phe 
            180                 185                 190         


Ile Gln Asn Asn Arg Tyr Thr Asp Asp Lys Lys Val Asn Phe Asn Phe 
        195                 200                 205             


Phe Leu Ser Met Gln Ser Ser Asn Asn Asn Leu Ser His Val Gly Val 
    210                 215                 220                 


Ala Gln Leu Ile Cys Leu Phe Leu Gln Lys Lys Asp Val Asp Asn Phe 
225                 230                 235                 240 


Leu Glu Asn Leu Pro Ile Tyr Asp Asn Arg Tyr Cys Leu Gly Ile Asp 
                245                 250                 255     


Glu His Met Ile Ile Lys Arg Ser Leu Ala Leu His Ser Ile Lys Leu 
            260                 265                 270         


Pro Lys Glu Arg Leu Asn Ser Glu Lys Lys Asp Met Ala Ile Ala Met 
        275                 280                 285             


Asp Met Leu Asn Glu Leu Lys Arg Cys Pro Lys Glu Leu Phe Asn Thr 
    290                 295                 300                 


Leu Pro Phe Asp Lys Gln Glu Arg Phe Arg Ile Ile Ser Ser Asp His 
305                 310                 315                 320 


Lys Glu Val Leu Leu Met Arg Ser Thr Asp Arg Phe Val Pro Leu Ile 
                325                 330                 335     


Leu Gln Tyr Ile Asp Cys Asn Lys Lys Phe Lys Asp Ile Arg Phe His 
            340                 345                 350         


Val Asn Met Gly Lys Leu Arg Tyr Leu Phe Ser Pro Asn Lys Leu Cys 
        355                 360                 365             


Ile Asp Asn Gln Glu Arg Val Arg Met Leu Glu His Leu Leu Asn Gly 
    370                 375                 380                 


Tyr Gly Arg Ile Asp Glu Val Glu Tyr Leu Arg Lys Ala Pro Asn Gly 
385                 390                 395                 400 


Thr Phe Gly Asn Thr Asn Ile Pro Ile Lys Gly Phe Gly Glu Ile Glu 
                405                 410                 415     


Arg Asp Ser Ala Asp Ser Asn Asn Tyr Pro Tyr Ile Val Asp Thr His 
            420                 425                 430         


Thr His Tyr Ile Leu Asn Asn Asn Lys Val Glu Phe Cys Phe Cys Glu 
        435                 440                 445             


Asp Ser Lys Asn Lys Asn Val Phe Pro Thr Ile Glu Lys Glu Ile Asn 
    450                 455                 460                 


Gly Lys Trp Tyr Val Glu Lys Thr Ala Pro His Cys Arg Ile Ser Phe 
465                 470                 475                 480 


Phe Glu Ile Pro Ala Met Ala Phe His Met Phe Leu Cys Gly Ser Glu 
                485                 490                 495     


Lys Thr Glu Lys Leu Ile Lys Asp Val Tyr Asn Asn Tyr Ile Ser Leu 
            500                 505                 510         


Phe Asn Ala Leu Lys Asn Gly Ala Leu Thr Glu Glu Asn Tyr Lys Asp 
        515                 520                 525             


Phe Asn Ile Pro Glu Cys Asp Met Pro Lys Lys Ile Leu Asp Phe Leu 
    530                 535                 540                 


Lys Gly Lys Ala Glu Gly Lys Ser Ile Asp Gly Tyr Val Lys Asn Ile 
545                 550                 555                 560 


Leu Lys Lys Glu Leu Lys Asp Thr Arg Lys Arg Ile Glu Gln Ala Pro 
                565                 570                 575     


Ser Glu Lys Asp Gln Met Pro Ser Lys Arg Asn Lys Ile Gly Thr Lys 
            580                 585                 590         


Ser Tyr Lys Arg Val Leu Thr Gly Lys Leu Ala Asp Phe Leu Ala Lys 
        595                 600                 605             


Asp Ile Val Lys Tyr Gln Pro Thr Leu Cys Ala Gly Asp Asp Tyr Gly 
    610                 615                 620                 


Ile Asp Arg Met Thr Gly Met Asn Tyr Arg Ile Met Gln Ala Thr Ile 
625                 630                 635                 640 


Ala Thr Tyr Asn Asp Asp Asp Asp Phe Asp Thr Phe Tyr Asn Val Phe 
                645                 650                 655     


Lys Met Ala Gly Leu Val Asp Gly Asp Glu Arg Lys Asn His Pro Phe 
            660                 665                 670         


Leu Lys Lys Val Leu Leu Ser Lys Pro Gln Asn Thr Val Ala Phe Asn 
        675                 680                 685             


Ile Lys Tyr Leu Lys Glu Lys Glu Ile Tyr Leu Arg Asn Ile Glu Lys 
    690                 695                 700                 


Lys Asn Ile Ile Pro Pro Phe Val Asn Arg Glu Arg Asn Lys Trp Cys 
705                 710                 715                 720 


Glu Arg Asp Cys Glu Tyr Tyr Arg Ile Leu Gly Glu Asn Leu Leu Asp 
                725                 730                 735     


Leu Pro Ile Glu Leu Pro Arg Gln Met Phe Tyr Lys Asp Ile Arg Ala 
            740                 745                 750         


Gln Leu Glu Pro Leu Met Pro Glu Ile Asp Phe Ser Gln Thr Asn Thr 
        755                 760                 765             


Thr Tyr Leu Ile Ala Glu Tyr Leu Lys Arg Val Arg Gly Asp Asp Phe 
    770                 775                 780                 


Gln Glu Phe Tyr Ser Trp Glu Arg Asn Tyr Arg Tyr Ile Asp Phe Leu 
785                 790                 795                 800 


Lys Cys Ile Arg Asp Asp Asn Gly Arg Ile Cys Ala Gln Tyr Thr Thr 
                805                 810                 815     


Thr Glu Glu Arg Glu Ser Leu Trp Glu Asp Ser Lys Asn Arg Thr Ala 
            820                 825                 830         


Glu Tyr Lys Arg Ser Glu Glu Gln Lys Asn Glu Lys Lys Asp Lys Asn 
        835                 840                 845             


Phe Glu Asp Ser Leu Glu Glu Arg Ile Ser Ser Ser His Ile Lys Phe 
    850                 855                 860                 


Gln Asn Thr Glu Lys His Ile Arg Arg Tyr Lys Val Gln Asp Ala Leu 
865                 870                 875                 880 


Leu Phe Met Ile Ala Glu Lys Gln Phe Gly Lys Tyr Leu Asp Asp Ile 
                885                 890                 895     


Lys Ala Lys Asn Phe Lys Leu Lys Asp Ile Met Pro Asp Thr Asp Lys 
            900                 905                 910         


Gly Ile Leu Ser Glu Thr Met Pro Ile Asp Phe Thr Phe Thr Lys Lys 
        915                 920                 925             


Asn Ile Lys Tyr Asn Ile His Ala Lys Asn Leu Lys Phe Lys Glu Tyr 
    930                 935                 940                 


Gly Asp Leu Phe Ile Leu Ala Asn Asp Lys Arg Leu Glu Ser Leu Trp 
945                 950                 955                 960 


Lys Ile Leu Ala Thr Asp Thr Val Asn Lys Glu Glu Ile Ser Glu Glu 
                965                 970                 975     


Phe Ala Lys Tyr Asp Phe Cys Arg Pro Asp Ile Thr Lys Leu Val Leu 
            980                 985                 990         


Asp Phe Glu Lys Asp Val Leu Glu  Lys Tyr Pro Glu Ile  Ile Glu Glu 
        995                 1000                 1005             


Ala Glu  Lys Glu Tyr Lys Lys  Phe Asp Phe Lys Phe  Ile Leu Asp 
    1010                 1015                 1020             


Trp Leu  Ile Asn Lys Lys Lys  Leu Asn Tyr Gly Ile  Arg Asn Lys 
    1025                 1030                 1035             


Leu Leu  Leu Ile Arg Asn Ala  Phe Asn His Asn Ser  Tyr Pro Asp 
    1040                 1045                 1050             


Lys Lys  Tyr Ala Glu Val Arg  Glu Leu Pro Glu Ile  Ala Thr Asn 
    1055                 1060                 1065             


Leu Lys  Lys Thr Phe Asp Glu  Asn Ala Lys Lys Tyr  Glu 
    1070                 1075                 1080     


<210>  1389
<211>  1199
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1389

Met Asn Thr Phe Ile Asp Ser Phe Ile Arg Arg Val Gln Ile Gln Asn 
1               5                   10                  15      


Gln Asn Gln Ser Trp Pro Lys Arg Pro Lys Tyr Val Arg Pro Val Glu 
            20                  25                  30          


Asn Ile Arg Pro Asp Asp Leu Ala Phe Gln Ser His Phe Thr Ala Tyr 
        35                  40                  45              


Leu Asn Met Ala Arg Gln Asn Cys Cys Ile Ile Leu Gly His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Gly Phe Lys Ala Ser Ser Val Lys Asp Thr Thr Leu Thr 
65                  70                  75                  80  


Ser Ser Pro Leu Leu Gly Gln Asn Gly Leu Leu Ser Pro Lys Lys Glu 
                85                  90                  95      


Val Ser Asp Leu Ile Arg Gly Arg Leu Leu Ser Ala Phe Pro Met Leu 
            100                 105                 110         


Asp Pro Met Ile Arg Tyr Arg Lys Ala Val Asp Lys Glu Lys Asp Asp 
        115                 120                 125             


Tyr Ala Arg Ile Ile Ile Thr Ser Glu Asp Val Ser Glu Met Leu Arg 
    130                 135                 140                 


Asp Leu Leu Asp Val Leu Ser Tyr Tyr Arg Asp Met Ala Ser His Val 
145                 150                 155                 160 


Val Phe Asn Asp Asp Arg Ser Val Ser Ala Glu Phe Ala Ser Lys Glu 
                165                 170                 175     


Lys Lys Val Ala Glu Cys Leu Asn Tyr Met Met Thr Val Ser Leu Arg 
            180                 185                 190         


Ile Val Lys Asp Arg Phe Ser Leu Ala Val Ser Asp Leu Asp Phe Tyr 
        195                 200                 205             


Asn Arg Asn Arg Tyr Met Met Val Asn Arg Lys Pro Leu Leu Asn Ala 
    210                 215                 220                 


Gly Phe Ala His Ala Val Arg Thr Glu Asp Tyr Arg Leu Thr Leu Met 
225                 230                 235                 240 


Gly Leu Val Leu Leu Cys Cys Gln Phe Ile Glu Lys Gln Tyr Ala Ser 
                245                 250                 255     


Met Phe Phe Asp Ala Leu Asp Lys His Ser Asn Gly Ala Arg Phe Tyr 
            260                 265                 270         


Gly Ile Ala Asp Ala Met Pro Met Val Asn Val Gly Thr Lys Asp Lys 
        275                 280                 285             


Pro Lys Lys Ile Pro Met Tyr Thr Gly Asp Glu Ala Gln Lys Gln Val 
    290                 295                 300                 


Gln Lys Gln Arg Met Ala Leu Arg Glu Ala Tyr Ser Val Tyr Arg Val 
305                 310                 315                 320 


Arg Ile Pro Lys Glu Arg Leu Glu Ser Thr Arg Ser Asp Met Ala Leu 
                325                 330                 335     


Ala Leu Asp Ile Leu Asn Glu Leu Gly Lys Cys Pro Glu Glu Leu Phe 
            340                 345                 350         


Glu His Leu Ser Pro Glu Asp Arg Glu Ser Phe Lys Asn Glu Glu Gly 
        355                 360                 365             


Val Leu Met Lys Arg Tyr Ser Asp Arg Phe Pro Gln Leu Ala Leu Arg 
    370                 375                 380                 


Trp Leu Asp Glu Asn Glu Lys Phe Asn Asn Leu Arg Phe His Val Thr 
385                 390                 395                 400 


Phe Gly Lys Tyr Arg Trp Leu Phe Cys Gln Asp Lys Lys Cys Ala Asp 
                405                 410                 415     


Gly Ser Val Arg Pro Arg Trp Leu Gln Lys Glu Leu Asn Gly Phe Gly 
            420                 425                 430         


Arg Ile Gln Thr Val Glu Arg Lys Arg Thr Gly Leu Glu Pro Gly Trp 
        435                 440                 445             


Asp Gly Thr Gly Leu Ile Arg Lys Phe Glu Glu Val Val Thr Asp Glu 
    450                 455                 460                 


Val Gln Lys Glu Pro Tyr Ile Thr Asp Phe Arg Thr Gln Tyr Leu Phe 
465                 470                 475                 480 


Asn Arg Asp Lys Ile Gly Ile Ser Leu Ser Glu Tyr Met Pro Gly Ile 
                485                 490                 495     


Gly Asp Ile His Ser Gly Lys Glu Trp Gly Lys His Ala Gly Val Pro 
            500                 505                 510         


Asp Phe Tyr Leu Ser Val Tyr Asp Ile Pro Ala Met Leu Phe Leu Thr 
        515                 520                 525             


Trp Leu Leu Gly Lys Asn Ser Ser Ala Val Glu Lys Leu Leu Ala Asn 
    530                 535                 540                 


Cys Lys Ala Ala Tyr Met Lys Leu Phe Asp Asp Leu Ala Lys Gly Lys 
545                 550                 555                 560 


Trp Glu Gly Glu Arg Asn Val Ser Asp Tyr Cys Ala Gly Glu Gly Thr 
                565                 570                 575     


Val Arg Tyr Thr Leu Arg Trp Tyr Asp Val Pro Met Lys Ile Arg Arg 
            580                 585                 590         


Lys Met Pro Leu Leu Gly Gly Asp Arg Asp Phe Glu Glu Lys Lys Ser 
        595                 600                 605             


Phe Glu Thr Leu Ala Gln Glu Ala Leu Thr Arg Met Leu Gln Arg Thr 
    610                 615                 620                 


Glu Asn Gln Leu Glu Lys Phe Asp Arg Asp Leu Ala Ala Ala Arg Asp 
625                 630                 635                 640 


Leu Lys Ala Asn Lys Gln Gly Lys Asp Arg Phe Val Asp Ile Arg Ala 
                645                 650                 655     


Gly Ser Leu Ala Thr Phe Leu Ala Arg Asp Ile Val Arg Leu Met Pro 
            660                 665                 670         


Val Ser Asp Asn Gly Arg Asn Lys Pro Thr Gly Leu Asn Tyr Ser Ile 
        675                 680                 685             


Val Gln Lys Ala Ile Ala Thr Tyr Lys Pro Ser Glu Gly Gly Leu Asp 
    690                 695                 700                 


Thr Leu Thr Gly Val Phe Arg Asp Ala Arg Ile Ile Gly Val Lys Gly 
705                 710                 715                 720 


Gly Ser His Pro Phe Leu Glu Arg Leu Leu Val Glu Lys Lys Pro Ser 
                725                 730                 735     


Ser Val Leu Ala Leu Tyr Arg His Tyr Leu Glu Tyr Arg Lys Glu Tyr 
            740                 745                 750         


Leu Lys Lys Ala Leu Glu Asp Glu Asn Lys Ala Glu Leu Lys Asn Leu 
        755                 760                 765             


Pro Phe Leu Lys Ser Gly Arg Gln Lys Tyr Ala Val Asp Gln Ala Asp 
    770                 775                 780                 


Tyr Ala Arg Arg Leu Ala Glu Ser Tyr Arg Asn Cys Pro Ile Tyr Leu 
785                 790                 795                 800 


Pro Thr Gly Ile Phe Thr Asp Met Leu Lys Asp Gln Leu Ala Lys Ile 
                805                 810                 815     


Asp Val Met Lys Pro Val Leu Glu Asn Asp Lys Val Asn Ala Ser Tyr 
            820                 825                 830         


Leu Ile Ala Gln Tyr Phe Glu Lys Val Glu His Asp Ser Glu Gln Pro 
        835                 840                 845             


Leu Tyr Arg Leu Lys Arg Asn Tyr Arg Val Phe Asp Leu Leu Glu Phe 
    850                 855                 860                 


Thr Asp Glu Pro Lys Tyr Trp Arg Leu Asn Glu Arg Ser Asp Lys Ala 
865                 870                 875                 880 


Gly Lys Tyr Gly Leu Ala Lys Arg Asn Ile Phe Trp Asn Arg Met Gly 
                885                 890                 895     


Glu Tyr Tyr Lys Gly Leu Lys Lys Phe Tyr Lys Gly Tyr Glu Ser Lys 
            900                 905                 910         


Arg Thr Ala Val Asp Trp Arg Glu Lys Leu Lys Ile Val Glu Ala Glu 
        915                 920                 925             


His Ala Met Trp Asn Arg Leu Lys Asp Ala Ser Gly Glu Ala Arg Leu 
    930                 935                 940                 


Lys Met Lys Asp Gly Val Phe Tyr Ser Arg Leu Leu Ser Ala Arg Lys 
945                 950                 955                 960 


Glu Tyr Asp Asp Cys Glu Arg Ala Leu Arg Arg Leu Lys Val Gln Asp 
                965                 970                 975     


Ile Val Leu Phe Leu Ala Ala Arg Glu Thr Leu Ile Leu Pro Lys Asp 
            980                 985                 990         


Lys Val Phe Arg Leu Lys Asn Leu  Ser Leu Ser Glu Gly  Asn Lys Asn 
        995                 1000                 1005             


Ile Leu  Ser Ser Ala Ile Asp  Glu Phe Ser Val Asp  Val Val Trp 
    1010                 1015                 1020             


Thr Glu  Lys Glu Gly Ala Ala  Lys Val Thr His Ser  Ala Ser Ile 
    1025                 1030                 1035             


Lys Glu  Asn Asp Val Val Ile  Lys Asn Tyr Gly Arg  Met Phe Arg 
    1040                 1045                 1050             


Leu Leu  His Asp Asp Arg Val  Lys Thr Leu Leu Pro  His Ile Tyr 
    1055                 1060                 1065             


Asp Ser  Ala Leu Ser Glu Asn  Ile Thr Gly Asp Arg  Ile Thr Val 
    1070                 1075                 1080             


Lys Asp  Asn Lys Val Ile Ile  Asp Lys Ser Leu Phe  Asp Glu Asp 
    1085                 1090                 1095             


Leu Met  Asn Tyr Asp Leu Arg  Arg His Glu Ile Cys  Glu Ile Ile 
    1100                 1105                 1110             


Leu Arg  Phe Glu Ala Ala Ser  Ile Lys Arg Phe Gly  Leu Asp Gly 
    1115                 1120                 1125             


Arg Val  Asp Phe Lys Ala Ala  Leu Asp Ala Leu Thr  Gly Arg Ser 
    1130                 1135                 1140             


Leu Leu  Asn Asp Glu Asp Ala  Arg Ile Leu Ser Ala  Ile Arg Asn 
    1145                 1150                 1155             


Ala Tyr  Asn His Asn Lys Tyr  Pro Ala Lys Gly Thr  Asp Val Lys 
    1160                 1165                 1170             


Val Asn  Val Met Ala Leu Pro  Lys Leu Thr Glu Asp  Leu Leu Arg 
    1175                 1180                 1185             


Ile Phe  Ser Asp Thr Gly Asn  Asn Arg Val Arg 
    1190                 1195                 


<210>  1390
<211>  1090
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1390

Met Asn Ile Pro Ala Leu Val Glu Asn Gln Lys Lys Tyr Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Val Met Ala Met Leu Asn Ala Gln Thr Val Leu Asp His Ile 
            20                  25                  30          


Gln Lys Val Ala Asp Ile Glu Gly Glu Gln Asn Glu Asn Asn Glu Asn 
        35                  40                  45              


Leu Trp Phe His Pro Val Met Ser His Leu Tyr Asn Ala Lys Asn Gly 
    50                  55                  60                  


Tyr Asp Lys Gln Pro Glu Lys Thr Met Phe Ile Ile Glu Arg Leu Gln 
65                  70                  75                  80  


Ser Tyr Phe Pro Phe Leu Lys Ile Met Ala Glu Ser Gln Arg Glu Tyr 
                85                  90                  95      


Ser Asn Lys Lys Asn Lys Gln Asn Arg Val Glu Val Asn Ser Asn Asp 
            100                 105                 110         


Ile Phe Glu Val Leu Lys Arg Ala Phe Gly Val Leu Lys Met Tyr Arg 
        115                 120                 125             


Asp Gln Thr Asn His Tyr Lys Thr Tyr Asp Glu Lys Leu Ile Asp Gly 
    130                 135                 140                 


Cys Glu Phe Leu Thr Arg Thr Glu Leu Pro Leu Ser Gly Met Ile Asn 
145                 150                 155                 160 


Ser Tyr Tyr Thr Val Ala Leu Arg Asn Ile Lys Glu Arg Tyr Gly Tyr 
                165                 170                 175     


Lys Thr Glu Asp Leu Ala Phe Ile Gln Asp Asn Arg Tyr Lys Phe Val 
            180                 185                 190         


Lys Asp Ala Tyr Gly Lys Arg Lys Ser Gln Val Asn Thr Gly Phe Phe 
        195                 200                 205             


Leu Ser Leu Gln Asp Tyr Asn Gly Asp Thr Thr Lys Lys Leu His Leu 
    210                 215                 220                 


Ser Gly Val Gly Ile Ala Leu Leu Ile Cys Leu Phe Leu Asp Lys Gln 
225                 230                 235                 240 


Tyr Ile Asn Leu Phe Leu Ser Arg Leu Pro Ile Phe Ser Ser Tyr Asn 
                245                 250                 255     


Ala Gln Ser Glu Glu Arg Arg Ile Ile Ile Arg Ser Phe Gly Ile Asn 
            260                 265                 270         


Ser Ile Lys Leu Pro Lys Asp Arg Ile His Ser Glu Lys Ser Asn Lys 
        275                 280                 285             


Ser Val Ala Met Asp Met Leu Asn Glu Val Lys Arg Cys Pro Asp Glu 
    290                 295                 300                 


Leu Phe Thr Thr Leu Ser Ala Glu Lys Gln Ser Arg Phe Arg Ile Ile 
305                 310                 315                 320 


Ser Asp Asp His Asn Glu Val Leu Met Lys Arg Ser Ser Asp Arg Phe 
                325                 330                 335     


Val Gln Leu Leu Leu Gln Tyr Ile Asp Tyr Gly Lys Leu Phe Lys Asn 
            340                 345                 350         


Ile Arg Phe His Val Asn Met Gly Lys Leu Arg Tyr Leu Leu Lys Ala 
        355                 360                 365             


Asp Lys Lys Cys Ile Asp Gly Gln Thr Arg Val Arg Val Ile Glu Gln 
    370                 375                 380                 


Pro Leu Asn Gly Phe Gly Arg Leu Asp Glu Val Glu Val Leu Arg Lys 
385                 390                 395                 400 


Gln Glu Asn Gly Thr Phe Gly Lys Ser Gly Ile Arg Ile Arg Asp Phe 
                405                 410                 415     


Glu Asn Met Lys Arg Asp Asp Asp Asn Pro Ala Asp Tyr Pro Tyr Ile 
            420                 425                 430         


Val Asp Ala Tyr Thr His Tyr Met Leu Glu Asn Asn Lys Val Glu Met 
        435                 440                 445             


Tyr Ile Ser Lys Asp Asp Asn Pro Ala Pro Leu Leu Pro Gly Ile Glu 
    450                 455                 460                 


Asp Asp Arg Tyr Ala Val Lys Thr Ile Pro Ser Cys Arg Met Ser Thr 
465                 470                 475                 480 


Leu Glu Phe Pro Ala Met Ala Phe His Met Phe Leu Leu Gly Ser Glu 
                485                 490                 495     


Arg Thr Glu Arg Arg Ile Lys Asp Val Tyr Asp Lys Tyr Lys Lys Leu 
            500                 505                 510         


Phe Met Ala Met His Lys Glu Glu Val Thr Ala Glu Asn Ile Ala Ser 
        515                 520                 525             


Phe Gly Ile Ala Glu Arg Asp Leu Pro Lys Lys Ile Leu Asp Ile Ile 
    530                 535                 540                 


Asn Gly Asn Ala Gln Gly Lys Asp Val Asp Ala Tyr Ile Lys Ala Thr 
545                 550                 555                 560 


Ile Asp Asp Met Ile Ala Asp Thr Glu His Arg Ile Lys Lys Leu Lys 
                565                 570                 575     


Asp Asp Arg Lys Ala Val Arg Ser Ala Asp Asn Lys Met Gly Lys Arg 
            580                 585                 590         


Cys Phe Lys Arg Ile Ser Thr Gly Lys Leu Ala Asp Phe Leu Ala Lys 
        595                 600                 605             


Asp Ile Val Met Phe Gln Pro Ser Ile Tyr Asp Gly Glu Asn Lys Ile 
    610                 615                 620                 


Thr Gly Leu Asn Tyr Arg Ile Met Gln Ser Ala Ile Ala Val Tyr Asp 
625                 630                 635                 640 


Ser Gly Asp Asp Tyr Glu Ala Lys Gln Gln Phe Arg Leu Met Phe Glu 
                645                 650                 655     


Asn Ala Gln Leu Ile Gly Lys Gly Ile Thr Glu Ala His Pro Phe Leu 
            660                 665                 670         


Tyr Lys Val Phe Ala Arg Ser Val Pro Ala Asn Ala Val Asp Phe Tyr 
        675                 680                 685             


Glu Arg Tyr Leu Ile Glu Arg Lys Tyr Tyr Leu Thr Ala Leu Phe Asn 
    690                 695                 700                 


Glu Ile Lys Lys Gly Asn Lys Val Asp Ile Pro Phe Ile Arg Arg Asn 
705                 710                 715                 720 


Gln Asn Lys Trp Lys Thr Pro Val Met Lys Thr Leu Gly Arg Ile Tyr 
                725                 730                 735     


Asn Glu Asp Leu Pro Val Glu Leu Pro Arg Gln Met Phe Asp Asp Glu 
            740                 745                 750         


Ile Lys Ser His Leu Lys Ser Leu Ser Gln Met Ser Gly Ile Asp Phe 
        755                 760                 765             


Asp Asn Ala Asn Val Thr Tyr Leu Ile Ala Glu Tyr Met Lys Arg Val 
    770                 775                 780                 


Leu Gly Asp Asp Phe Gln Asn Phe Tyr Gln Trp Asn Arg Asn Tyr Arg 
785                 790                 795                 800 


Tyr Met Asp Met Leu Lys Gly Glu Tyr Asp Ser Lys Gly Thr Leu Leu 
                805                 810                 815     


Cys Asn Phe Thr Ser Val Glu Glu Arg Glu Ala Leu Trp Lys Glu Arg 
            820                 825                 830         


Glu Asp Arg Ser Gly Ser Tyr Arg Lys Leu Ala Thr Lys Lys Ile Lys 
        835                 840                 845             


Ser Asn Arg Leu Thr Arg Asn Ala Ser Thr Asp Glu Val Asn Ser Ile 
    850                 855                 860                 


Leu Asp Lys Arg Leu Ser Asn Ser Arg Asn Glu Tyr Gln Lys Asp Glu 
865                 870                 875                 880 


Lys Ile Ile Arg Arg Tyr Lys Val Gln Asp Ala Leu Leu Phe Leu Leu 
                885                 890                 895     


Ala Lys Lys Thr Leu Thr Glu Met Ala Asp Phe Asp Gly Asn Lys Phe 
            900                 905                 910         


Lys Leu Lys Glu Ile Met Pro Asp Thr Glu Lys Gly Ile Leu Ser Glu 
        915                 920                 925             


Ile Met Pro Met Thr Phe Thr Phe Glu Lys Gly Gly Glu Arg Tyr Thr 
    930                 935                 940                 


Ile Thr Ser Glu Gly Met Lys Leu Lys Asn Tyr Gly Asp Phe Phe Val 
945                 950                 955                 960 


Leu Ala Asn Asp Lys Arg Leu Cys Lys Leu Leu Lys Ile Val Gly Ser 
                965                 970                 975     


Asn Ser Val Ser Lys Glu Asp Ile Met Glu Glu Phe Lys Lys Tyr Asp 
            980                 985                 990         


Gln Cys Arg Pro Glu Ile Ala Ser  Ile Val Phe Asn Leu  Glu Lys Trp 
        995                 1000                 1005             


Ala Phe  Asp Thr Tyr Pro Glu  Leu Ser Ala Lys Val  Asp Arg Glu 
    1010                 1015                 1020             


Glu Gln  Val Asp Phe Lys Phe  Ile Leu Asn Val Leu  Leu Asn Lys 
    1025                 1030                 1035             


Lys Asn  Ile Asn Asn Glu Gln  Ser Tyr Ile Leu Arg  Lys Ile Arg 
    1040                 1045                 1050             


Asn Ala  Phe Asp His Asn Asn  Tyr Pro Asp Lys Gly  Leu Val Glu 
    1055                 1060                 1065             


Ile Lys  Ala Leu Pro Glu Ile  Ala Met Ser Ile Lys  Lys Thr Phe 
    1070                 1075                 1080             


Gly Glu  Tyr Ala Ile Met Lys  
    1085                 1090 


<210>  1391
<211>  1324
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1391

Met Ala Thr Phe Arg Phe Thr Asp Lys Ser Val Ser Ala Thr Tyr Tyr 
1               5                   10                  15      


Asn Met Ala Arg Asp Asn Phe His Gln Thr Met Val Glu Ile Leu Ser 
            20                  25                  30          


Lys Val Gly Val Lys Gly Glu Met Glu Gln Lys Ile Asp Asn Gln Leu 
        35                  40                  45              


Asp Glu Leu Gln Lys Asp Leu Glu Asn Pro Gln Lys Glu Ser Lys Phe 
    50                  55                  60                  


Lys Leu Ser Asn Glu Lys Gln Val Lys Leu Arg Lys Leu Leu Phe Glu 
65                  70                  75                  80  


His Phe Pro Ile Leu Gly Pro Ile Met Ala Ser Val Leu Phe Arg Asn 
                85                  90                  95      


Leu Asn Lys Ser Asp Asn Lys Gln Leu Gln Thr Lys Lys Ser Asn Val 
            100                 105                 110         


Val Asp Gly Asp Val His Asp Val Ser Leu Ser Glu Cys Leu Lys Val 
        115                 120                 125             


Leu Val Val Leu Ala Lys Cys Leu Thr Asp Thr Arg Asn Tyr Phe Thr 
    130                 135                 140                 


His Tyr Asn Pro Phe Asn Ser Gln Glu Ala Leu Cys Lys Met Tyr Glu 
145                 150                 155                 160 


Arg Gln Lys Lys Val Ser Ala Tyr Leu Asp Gln Val Phe Thr Ala Ser 
                165                 170                 175     


Arg Arg Ile Asn Lys Asn Arg Lys Gly Leu Thr Ser Val Glu Met Gln 
            180                 185                 190         


Phe Ile Thr Ser Glu Ala Tyr Lys Ala Leu Lys Asp Asp Asn Asp His 
        195                 200                 205             


Phe Ile Leu Asp Glu Lys Gly Arg Lys Lys Ile Gly Lys Asn Arg Asp 
    210                 215                 220                 


Tyr Tyr Phe Ser Ile Val Gly Glu Ser Phe Ile His Lys Glu Asp Ala 
225                 230                 235                 240 


Gln Phe Ile Gln Lys Val Phe Asp Gly Val Gln Ile Phe Glu Ala Asp 
                245                 250                 255     


Ser Lys Asn Asn Ala Leu Ser Asp Phe Gly Leu Leu Tyr Leu Cys Ser 
            260                 265                 270         


Cys Phe Ile Ser Arg His Tyr Ala Arg Leu Phe Val Asp Lys Ala Gly 
        275                 280                 285             


Leu Phe Thr His Ser Pro Tyr Ser Arg Ile Asn Asn Gly Val Leu Asn 
    290                 295                 300                 


Gln Ala Thr Lys Glu Asn Asn Ile Ile Leu Glu Met Leu Ser Ile Tyr 
305                 310                 315                 320 


Arg Ile Arg Met Phe Lys Gly Asn Arg Leu Asp Ile His Asp Thr Lys 
                325                 330                 335     


Thr Ser Ile Ala Leu Asp Met Leu Asn Glu Leu Asn Arg Cys Pro Met 
            340                 345                 350         


Pro Leu Tyr Glu His Leu Ser Pro Glu Gly Lys Met Ala Phe Glu Asp 
        355                 360                 365             


Lys Val Thr Arg Pro Asn Glu Asn Thr Pro Asp Val Ser Leu Arg Leu 
    370                 375                 380                 


Arg His Thr Asp Arg Phe Pro Thr Leu Ala Leu Lys Met Ile Asp Ala 
385                 390                 395                 400 


Thr Asp Ile Leu Pro Lys Ile Arg Phe Gln Val Gln Leu Gly Thr Tyr 
                405                 410                 415     


Arg Phe Arg Phe Tyr Glu Lys Asp Cys Ile Asp Gly Asn Arg Gln Leu 
            420                 425                 430         


Arg Cys Leu Ser Lys Glu Ile Asn Gly Phe Gly Arg Leu Gln Asp Ile 
        435                 440                 445             


Glu Glu Leu Arg Lys Arg Val Trp Glu Asn Thr Thr Ser Gly Glu Gln 
    450                 455                 460                 


Glu Glu Asn Lys Ile Gln Val Lys Glu Tyr Val Ser Thr Leu Leu Glu 
465                 470                 475                 480 


Asp Glu Glu Thr Thr Leu Asp Leu Leu Gln Pro Leu Gly Asp Lys Pro 
                485                 490                 495     


Gly Asn Asn Pro Tyr Ile Thr Asp His Gln Ala Ser Tyr Asn Ile His 
            500                 505                 510         


Asn Asn Arg Ile Gly Leu Tyr Trp Glu Ser Thr Asn Pro Ala Lys Asn 
        515                 520                 525             


His Tyr Leu Cys Gly Asn Gly Leu Thr Tyr Leu Pro Thr Leu Asn Tyr 
    530                 535                 540                 


Lys Val Val Asp Ser Gly Gly Lys Ile Leu Gln Lys Ala Asp Ile Asp 
545                 550                 555                 560 


Gln Pro Ser Pro Leu Cys Ser Leu Ser Thr Tyr Glu Leu Gly Ser Leu 
                565                 570                 575     


Leu Phe Tyr His Phe Ile Tyr Lys Thr Tyr Gly Gly Lys Lys Leu Gly 
            580                 585                 590         


Met Arg Thr Ala Glu Gln Ile Ile Ile Asp Lys Tyr Asn Asn Leu Ile 
        595                 600                 605             


Arg Phe Phe Lys Glu Ile Glu Ala His Gly Arg Ser Ser Phe Tyr Ala 
    610                 615                 620                 


Thr Val Pro Gly Lys Lys Thr Asp Glu Glu Leu Gln Met Lys Leu Asp 
625                 630                 635                 640 


Asp Tyr Ala Leu Ser Ile Ser Glu Ile Pro Asp Lys Leu Arg Ile Tyr 
                645                 650                 655     


Leu Arg Asn Met Phe Val Thr Tyr Pro Ser Ser Thr Ser Ser Lys Leu 
            660                 665                 670         


Val Gly Glu Arg Leu Val Lys Val Tyr Trp Arg Leu Gln His Phe Lys 
        675                 680                 685             


Glu Asp Arg Lys Lys Ile Gly Asp Lys Asp Asn Lys Tyr Ala Lys Lys 
    690                 695                 700                 


Gly Tyr Ala Asp Ile Arg His Gly Gln Ile Ala Arg Tyr Leu Ala Glu 
705                 710                 715                 720 


Ser Ile Val Asp Trp Leu Pro Glu Ala Ala Arg Ala Arg Thr Ile Leu 
                725                 730                 735     


Thr Gly Leu Asn Phe Asn Lys Leu Gln Ala Ala Leu Ala Thr Phe Asp 
            740                 745                 750         


Gly Ser Glu Gly His Gln Phe Ser Asp Ile Gln Phe Leu Met Arg Gln 
        755                 760                 765             


Ala His Leu Leu Ser Gln Glu Cys Glu Gly Glu Gly Leu Ala Gln Val 
    770                 775                 780                 


Thr Ile Glu Gly His Pro Phe Leu Asn Gln Ile Ile Asp Met Asn Pro 
785                 790                 795                 800 


Gln Asn Ile Glu Val Phe Tyr Ser Arg Tyr Leu Glu His Glu Lys Arg 
                805                 810                 815     


His Leu Thr Lys Phe Leu Glu Val Glu Val Tyr Asn Lys Lys Asn Asn 
            820                 825                 830         


Ser Tyr Lys Tyr Leu Pro Ile Asp Asn Arg Tyr Ile Pro Thr Gly Lys 
        835                 840                 845             


Glu Val Phe Thr Phe Lys Asp Asp Ile Asp Leu Arg Ala Ile Pro Phe 
    850                 855                 860                 


Ile His Pro Asn Arg Asp Lys Trp Lys Lys Arg Asn Asp Val Phe Cys 
865                 870                 875                 880 


Lys Gln Leu Ala Lys Arg Tyr Gln Glu His Ile Glu Leu Pro Asp Gly 
                885                 890                 895     


Leu Phe Thr Arg Glu Val Ile Lys Leu Leu Arg Leu Ala Pro Glu Cys 
            900                 905                 910         


Glu Val Met Phe Asp Asn Gly Phe Lys Glu Glu Asp Cys Asn Met Ser 
        915                 920                 925             


His Leu Val Asn Leu Tyr Leu Glu Arg Val Leu Lys Asp Gln Ser Gln 
    930                 935                 940                 


Ser Tyr Tyr Gly Leu Gly Asp Lys Arg Phe Tyr Arg Ser Tyr Arg Leu 
945                 950                 955                 960 


Phe Asp Ile Leu Tyr Gly Lys Val Val Arg Asn Glu Gln Leu Pro Tyr 
                965                 970                 975     


Tyr Leu Ser Cys Asp Glu Ile Met Glu Lys Ile Gly Ser Lys Glu Gly 
            980                 985                 990         


Arg Asn Lys Val Lys Lys Glu Ile  Asp Ser Leu Val Ala  Arg Met Thr 
        995                 1000                 1005             


Asn Arg  Asp Arg Gly Asn Cys  Lys Thr Leu Glu Glu  Ala Lys Lys 
    1010                 1015                 1020             


Lys Lys  Glu Asp Ile Leu Val  Asp Ala Ile Asn Gln  Val Lys Lys 
    1025                 1030                 1035             


Asn Glu  Lys Thr Ile Arg Arg  Phe Lys Thr Gln Asp  Ile Ile Leu 
    1040                 1045                 1050             


Phe Leu  Ile Ala Lys Gln Val  Leu Ile Gln Thr Asp  Glu Thr Ile 
    1055                 1060                 1065             


Lys Asn  Asn Ala Gln Ser Gln  Ser Glu Lys Phe Val  Ala Asp Glu 
    1070                 1075                 1080             


Ser Lys  Thr Ile Cys Leu Gly  Ser Thr Asn Pro Ile  Ser Tyr Glu 
    1085                 1090                 1095             


Gln Lys  Glu Asp Leu Glu Ser  Lys His Arg Ser Gly  Leu Ala Arg 
    1100                 1105                 1110             


Met Arg  Leu Ala Asp Val Phe  Glu Gly Asp Ser Leu  Asn Ile Pro 
    1115                 1120                 1125             


Leu Asp  Gln Thr Tyr Tyr His  Thr Ile Ser Trp Ile  Leu Lys Asp 
    1130                 1135                 1140             


Ser Asp  Gly Asn Glu Val Lys  Asp Ala Lys Gly Ser  Arg Ile Lys 
    1145                 1150                 1155             


Val Val  Arg Thr Val Arg Ile  Thr Gln Glu Asp Met  Ser Ile Lys 
    1160                 1165                 1170             


Asn Tyr  Gly Arg Ile Phe Gln  Ile Leu Ser Asp Lys  Arg Leu Asp 
    1175                 1180                 1185             


Asp Leu  Leu Lys Met Leu Ile  Gln Tyr Val Glu Ser  Asn Ala Pro 
    1190                 1195                 1200             


Ile Asn  Gly Asn Ser Tyr Ser  Ile Ala Tyr Asn Asp  Val Thr Ser 
    1205                 1210                 1215             


Glu Phe  Ala Asn Phe Asp His  Leu Arg Pro Glu Val  Phe Lys Glu 
    1220                 1225                 1230             


Ile His  Arg Leu Glu Ser Glu  Ala Phe Pro Lys Leu  Glu Asp Lys 
    1235                 1240                 1245             


Gln Ser  Glu Leu Thr Tyr Ser  Phe Asn Gly Leu Met  Gly Leu Leu 
    1250                 1255                 1260             


Phe Gln  Glu Asn Ala Ala Lys  Ser Ile Ile Asn Ile  Arg Asn Ala 
    1265                 1270                 1275             


Phe Val  His Gly Ser Tyr Arg  Val Asn Asn Ile Ile  Trp Glu Gly 
    1280                 1285                 1290             


Pro Asp  Ser Gln Ser Ala Glu  Leu Val Ala Pro Asn  Val Ser Arg 
    1295                 1300                 1305             


Lys Met  Lys Asp Arg Ile Ser  Pro Lys Asp Ser Lys  Glu Thr Lys 
    1310                 1315                 1320             


Tyr 
    


<210>  1392
<211>  1300
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1392

Met Asn Asn Ser Val Asn Ser Phe Ala Leu Val Asn Glu Ser Ser Gly 
1               5                   10                  15      


Arg Gly Lys Tyr Val Ala Gly Thr Tyr Phe Glu Ile Ala Ile His Asn 
            20                  25                  30          


Phe Phe Lys Thr Ile Asp Phe Val Leu Arg Arg Val Asn Ile Arg Lys 
        35                  40                  45              


Ser Asp Lys Gln Trp Ala Asp Gly Phe Ala His Leu Gly Asn Trp Thr 
    50                  55                  60                  


Asp Glu Arg Met Gly Lys Val Leu Glu Gln Leu Ala Leu Ala Glu Met 
65                  70                  75                  80  


Ser Pro Thr Gln Leu Ser Arg Leu Ser Arg Leu Leu Tyr His His Phe 
                85                  90                  95      


Pro Phe Phe Ser Pro Ile Met Ala Asp Ala Ala Asp His Gln Val Tyr 
            100                 105                 110         


Leu Arg Val Asn Glu Ile Lys Glu Ile Glu Gln Glu Ile Thr Glu Ser 
        115                 120                 125             


Asp Lys Lys Ile Lys Lys Asn Pro Val Asn Lys Glu Leu Val Gln Ser 
    130                 135                 140                 


Ile Asn Glu Ala Arg Ile Arg Leu Lys Ala Ala His Asn Ser Leu Glu 
145                 150                 155                 160 


Arg Gln Leu Ala Ser Thr Thr Ala Lys Glu Val Leu Ala Lys Leu Ala 
                165                 170                 175     


Val Met Ala Tyr Ala Met Asn Phe Tyr Arg Asn Gln Tyr Ser His Lys 
            180                 185                 190         


Cys His Phe Glu Thr Leu Asn Glu Lys Thr Leu Gln Glu Glu Asn Glu 
        195                 200                 205             


Gln Asn Leu Ala Phe Trp Leu Glu Val Ile Phe Lys Gly Ala Arg Ser 
    210                 215                 220                 


Ile Ile Leu Asp Arg Lys Glu His Ser Gln Glu Asp Thr Lys Phe Leu 
225                 230                 235                 240 


Thr Gln Asp Gly Asn Leu His Tyr Asn Val Asn Lys Ser Lys Lys Ser 
                245                 250                 255     


Thr Arg Asn Pro Asn Phe Tyr Phe Ser Pro Gly Lys Lys Asn Gly Gln 
            260                 265                 270         


Lys Trp Leu Ile Thr Asp Phe Gly Arg Tyr Tyr Phe Cys Ser Leu Phe 
        275                 280                 285             


Leu Gln Arg Ser Asp Ala Ile Glu Phe Gly Lys Asn Val Gly Leu Tyr 
    290                 295                 300                 


Thr Asp Ser Pro Phe Lys Leu Ser Asn Glu Glu Arg Asn Lys Leu Gln 
305                 310                 315                 320 


Leu Glu Glu Lys His Arg Ala Leu Glu Glu Gln Lys Ile Val Asp Lys 
                325                 330                 335     


Glu Gly Asp Gly His Lys Val Asn Pro Arg Ile Ile Ser Asn Thr Glu 
            340                 345                 350         


Ser Val Gln Asn Thr Ile Ile Gln Glu Met Leu Asp Val Tyr Arg Leu 
        355                 360                 365             


Arg Ile Pro Arg Glu Gly Arg Ile Asp Ala Met Met Asn Glu Gly Thr 
    370                 375                 380                 


Leu Ile Met Asp Ile Leu Asn Glu Leu Arg Arg Cys Pro Lys Ser Val 
385                 390                 395                 400 


Tyr Glu Thr Phe Ser Pro Ala Asp Lys Lys Lys Phe Asn Lys Val Gly 
                405                 410                 415     


Thr Asn Pro Asp Gly Ser Lys Ser Glu Met Lys Leu Ile Arg Tyr His 
            420                 425                 430         


Asp Arg Phe Pro Tyr Leu Ala Leu Arg Met Ile Asp Gln Thr Asn Ala 
        435                 440                 445             


Ile Gly Asp Ile Arg Phe His Leu Arg Leu Gly Leu Phe Arg Tyr Arg 
    450                 455                 460                 


Phe Tyr Asn Lys Lys Thr Ile Ser Gly Glu Leu Val Asn Pro Val Arg 
465                 470                 475                 480 


Thr Ile Gln Lys Glu Val Asn Gly Phe Gly Arg Trp Gln Asp Val Glu 
                485                 490                 495     


Glu Gly Arg Lys Ser Leu Tyr Gly Lys Tyr Phe Gln Asn Arg Ile Ile 
            500                 505                 510         


Asn Asp Asp Gly Leu Glu Gln Pro Val Pro Asp Ser Leu Gln Ser Leu 
        515                 520                 525             


Pro Tyr Ile Thr Asp Trp His Ala Ser Tyr Asn Ile His Ala Cys Arg 
    530                 535                 540                 


Ile Gly Met Ala Trp Asn Leu Ser Gln Met Glu Asp Ala Leu Tyr Leu 
545                 550                 555                 560 


Pro Pro Leu Thr Phe Asp Asp Gly Asn Asn Arg Asn Arg Lys Ala Pro 
                565                 570                 575     


Leu Asp Met Pro Ala Pro Met Cys Tyr Met Ser Ile Tyr Asp Ile Pro 
            580                 585                 590         


Ala Leu Leu Phe Tyr Asn Tyr Leu Tyr Lys Arg Tyr His Ala Glu Arg 
        595                 600                 605             


Tyr Thr Ser Ala Gly Ile Leu Thr Ala Glu Ser Ile Ile Lys Asn Lys 
    610                 615                 620                 


Tyr Asn Ala Leu Asn Val Phe Phe Glu Phe Val Thr Ser Gly Ala Asp 
625                 630                 635                 640 


Leu Asn Ser Ile Lys Lys Lys Gln Ile Asp Leu Gly Leu Ala Asp Asn 
                645                 650                 655     


Glu Leu Pro Asp Lys Ile Arg Cys Phe Ile Gly Thr Lys Lys Leu Phe 
            660                 665                 670         


Asn Ile Asp Gly Lys Pro Leu Leu Asp Lys Asn Thr Arg Glu Gln Leu 
        675                 680                 685             


Leu Lys Glu Trp Arg Pro Glu Ala Glu Leu Arg Arg His Thr Ile Asn 
    690                 695                 700                 


Arg Leu Lys Ala Ile Ile Glu Glu Asp Thr Tyr Arg Ile Glu Ser Leu 
705                 710                 715                 720 


Gly Lys Lys Arg Glu Lys Ile Glu Val Gly Gly Arg Asn Asn Arg Tyr 
                725                 730                 735     


Gly Arg Lys Gly Arg Ala Asp Ile Arg Pro Gly Ala Ile Ala Arg Tyr 
            740                 745                 750         


Ile Thr Lys Ser Leu Met Leu Trp Gln Pro Ala Met Pro Val Ala Gly 
        755                 760                 765             


Gly Gly Lys Leu Thr Ser Ala Asn His Gln Ala Leu Ala Lys Tyr Leu 
    770                 775                 780                 


Glu Glu Tyr Gly Ser Asn Asp Glu Ser Leu Asn Asn Leu His Ser Ile 
785                 790                 795                 800 


Phe Gln Arg Ala Gly Leu Ile Gly Gly Thr His Pro His Pro Phe Ile 
                805                 810                 815     


Asn Lys Val Leu Lys Gln Lys Pro Met Ser Ile Leu Gln Leu Tyr Thr 
            820                 825                 830         


Phe Tyr Leu Glu Val Glu Lys Ala Tyr Ala Glu Arg Met Leu Ala Glu 
        835                 840                 845             


Val Lys Thr Asn Thr Asp Asp Ile Thr Leu Pro Pro Phe Ala His Pro 
    850                 855                 860                 


Asn Gly Leu Arg Trp Ser Thr Thr Leu Thr Glu Ala Ala Lys Arg Tyr 
865                 870                 875                 880 


Thr Thr Val Pro Asn Glu Gln Asn Asp Ala Ser Thr Asp Ser His Arg 
                885                 890                 895     


Ala Val Met Ser Leu Pro Asp Gly Leu Phe Thr Ser His Ile Ile Ser 
            900                 905                 910         


Leu Leu Arg Gln Ala Leu Pro His Asn Ser Glu Leu Glu Pro Met Arg 
        915                 920                 925             


Lys Ile Leu Glu Gly Asn Asn Asn Met Leu Gly Ala Ala Tyr Ile Ile 
    930                 935                 940                 


Arg Phe Trp Phe Asp Gln Val Glu Gly Asp Ala Pro Gln Ala Phe Tyr 
945                 950                 955                 960 


Asn Asn Asp Gly Asp Gln Tyr Arg Arg Phe Tyr Lys Thr Leu Ser Leu 
                965                 970                 975     


Leu Asn Pro His Arg Met Lys Asn Arg Gln Leu Ile Pro Asp Tyr Phe 
            980                 985                 990         


Ser Glu Ser Glu Ile Lys Glu Leu  Leu Gln Ile Met Lys  Lys Lys Asn 
        995                 1000                 1005             


Arg Asp  Gln Leu Arg Ser Ala  Val Met Lys Ala Tyr  Gly Leu Lys 
    1010                 1015                 1020             


Glu Asn  Lys Ala Glu Asp Ile  Lys Gln Arg Gln Asn  Ala Phe Leu 
    1025                 1030                 1035             


Glu Met  Leu His Asp Val Ser  Asp Ser Glu Gln Ala  Leu His Arg 
    1040                 1045                 1050             


Tyr Arg  Ile Gln Asp Ile Cys  Leu Phe Leu Ser Gly  Arg Ser Phe 
    1055                 1060                 1065             


Leu Val  Asp Ile Leu Thr Lys  Ser Met Gly Gly Asn  Ile Glu Lys 
    1070                 1075                 1080             


Lys Thr  Leu Glu Lys Ala Lys  Glu Met His Leu Arg  Asp Phe Gly 
    1085                 1090                 1095             


Phe Asp  Asn Glu Phe Glu Phe  Leu Asp Asn Ala Lys  Ile Pro Tyr 
    1100                 1105                 1110             


Val Phe  Lys Ile Gly Asn Met  Thr Ile Ser Met Pro  Ala Met Ser 
    1115                 1120                 1125             


Phe Lys  Asn Tyr Gly Thr Ile  Phe Arg Leu Leu Gly  Asp Glu Arg 
    1130                 1135                 1140             


Leu Lys  Gln Leu Leu Glu Gly  Leu Ser Ala Met Asn  Ile Tyr Glu 
    1145                 1150                 1155             


Val Thr  Phe Asn Asp Leu Thr  Thr Glu Phe Ala Ser  Tyr Asp Gln 
    1160                 1165                 1170             


Lys Arg  Ile Glu Val Met Lys  Leu Ala Gln Asp Ile  Glu Gln Met 
    1175                 1180                 1185             


Ala Ile  Ala Gly Asn Ile Tyr  Leu Asn Asp Pro Asp  Asp Pro Arg 
    1190                 1195                 1200             


Phe Tyr  Val Lys Asp Lys Asp  Gly Asn Ser Thr Asn  Leu Ala Met 
    1205                 1210                 1215             


Arg Asn  Asn Phe Asn Ser Leu  Val His Leu Leu Ser  His Tyr Phe 
    1220                 1225                 1230             


Glu Phe  Ala Asp Phe Phe Thr  Glu Leu Arg Asn Thr  Ile Ala His 
    1235                 1240                 1245             


Asn Arg  Tyr Pro Lys Lys Tyr  Lys Asp Ala Glu Asp  Lys Asn Arg 
    1250                 1255                 1260             


Asn Pro  Tyr Ser Glu Asp Leu  Pro Ala Ala Gly Tyr  Glu Gly Val 
    1265                 1270                 1275             


Leu Pro  Pro Asn Ile Phe Ala  Ser Met Lys Gln Ile  Leu Glu Asp 
    1280                 1285                 1290             


Lys Val  Ser Glu Lys Thr Asn  
    1295                 1300 


<210>  1393
<211>  1162
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1393

Met Glu Thr Thr Glu Asn Leu Lys Ser Tyr Asn Cys Gln Asn Ser Phe 
1               5                   10                  15      


Lys Arg Ile Phe Asp Phe Lys Gly Glu Ile Ala Pro Ile Ala Glu Lys 
            20                  25                  30          


Ala Cys Arg Asn Phe Glu Val Lys Ala Lys Asn Lys Val Asn Arg Glu 
        35                  40                  45              


Gln Arg Leu His Tyr Phe Ala Ile Gly His Thr Phe Lys His Ile Asp 
    50                  55                  60                  


Thr Glu Lys Leu Phe Lys Lys Thr Leu Asn Glu Glu Leu Arg Glu Lys 
65                  70                  75                  80  


Ile Pro Thr Gln Phe Leu Ala Leu Gln Ala Phe Asp Lys Ser Phe Cys 
                85                  90                  95      


Asp Glu Leu Glu Lys Ile Ile Ile Asp Lys Asp Asn Lys Lys Lys Tyr 
            100                 105                 110         


Gln Gly Ile Ile Pro Asp Ile Arg Asn Ile Asn Ser His Tyr Val His 
        115                 120                 125             


Asp Phe Gln Asn Ile Arg Leu Asp Thr Leu Ser Ser Cys Met Val Ser 
    130                 135                 140                 


Phe Ile Lys Glu Ser Phe Glu Leu Ala Ile Thr Gln Thr Tyr Leu Lys 
145                 150                 155                 160 


Glu Lys Glu Ile Ser Tyr Thr Gln Leu Ile Glu Gln Gly Asn Val Asp 
                165                 170                 175     


Lys Val Leu Val Ala Phe Met His Asp Lys Phe Tyr Pro Leu Asp Asp 
            180                 185                 190         


Lys Gly Ile Asn Leu Leu Glu Glu Ala Gln Arg Ser Leu Asp Glu Tyr 
        195                 200                 205             


Lys Thr Ile Arg Glu Lys Phe Lys Ser Leu Ser Lys Glu Asp Ala Ile 
    210                 215                 220                 


Asp Ser Leu Leu Phe Val Glu Val Asp Asn Asp Phe Asp Trp Lys Leu 
225                 230                 235                 240 


Tyr Gly Val His Pro Val Phe Lys Ile Thr Thr Gly Lys Tyr Leu Ser 
                245                 250                 255     


Phe Tyr Ala Cys Leu Phe Leu Leu Ser Met Phe Leu Tyr Lys Ser Glu 
            260                 265                 270         


Ala Glu Lys Leu Ile Gly Lys Ile Lys Gly Phe Lys Lys Gln Glu Lys 
        275                 280                 285             


Thr Glu Glu Lys Ser Lys Arg Arg Ile Phe Ser Phe Phe Ser Lys Lys 
    290                 295                 300                 


Phe Ser Ser Gln Asp Ile Asp Ser Glu Glu Asn His Leu Val Lys Phe 
305                 310                 315                 320 


Arg Asp Leu Ile Gln Tyr Leu Asn His Tyr Pro Leu Ala Trp Asn Lys 
                325                 330                 335     


Glu Leu Glu Leu Glu Ser Gln His Pro Ala Met Thr Asp Lys Leu Lys 
            340                 345                 350         


Ala Lys Ile Ile Glu Met Glu Ile Lys Arg Ser Phe Pro Ala Tyr Ser 
        355                 360                 365             


Asn Asn Glu Arg Phe His Val Phe Ala Lys Tyr Gln Ile Trp Gly Lys 
    370                 375                 380                 


Lys Tyr Phe Gly Lys Ser Ile Glu Gln Glu Tyr Ile Glu Gln Ser Phe 
385                 390                 395                 400 


Thr Glu Lys Glu Val Glu Gly Phe Asn Tyr Glu Ile Asp Ala Ser Pro 
                405                 410                 415     


Glu Leu Lys Asp Ala Asn Glu Lys Leu Asp Lys Leu Lys Ala Val Thr 
            420                 425                 430         


Gly Leu Tyr Gly Ala Lys Lys Asp Arg Asn Thr Lys Glu Ile Lys Lys 
        435                 440                 445             


Thr Glu Gly Ile Ile Asn Arg Ile Ile Arg Glu Lys Ala Pro Asn Pro 
    450                 455                 460                 


Val Lys Glu Lys Leu Lys Asn Arg Ile Glu Lys Asn Leu Leu Phe Val 
465                 470                 475                 480 


Ser Tyr Gly Arg Asn Gln Asp Arg Phe Met Asp Phe Ala Ile Arg Tyr 
                485                 490                 495     


Leu Ala Glu Thr Lys Tyr Phe Gly Glu Asp Ala Gln Phe Lys Thr Tyr 
            500                 505                 510         


Arg Phe Tyr Ser Thr Glu Glu Gln Asp Asp Glu Leu Leu Lys Leu Lys 
        515                 520                 525             


Glu Thr Gln Ser Lys Lys Glu Tyr Asp Lys Gln Lys Tyr His Gln Gly 
    530                 535                 540                 


Lys Pro Val His Phe Thr Thr Phe Lys Asp His Leu Glu His Tyr Glu 
545                 550                 555                 560 


Ser Trp Asp Thr Pro Phe Val Ile Glu Asn Asn Ala Val Gln Val Lys 
                565                 570                 575     


Leu Thr Phe Ala Thr Glu Ile Lys Lys Ile Val Ser Val Gln Arg Gly 
            580                 585                 590         


Leu Met Val Tyr Phe Leu Glu Asp Ala Leu Thr Lys Glu Ser Asp Lys 
        595                 600                 605             


Ile Glu Asn Ala Gly Lys Leu Leu Leu Glu Gly Tyr Tyr Ala Phe His 
    610                 615                 620                 


Gln Lys Glu Phe Ser Gln Cys Lys Ser Val Leu Glu Gln Ser Ser Ser 
625                 630                 635                 640 


Ile Ser Pro Glu Glu Lys Thr Ala Phe Lys Lys Leu Leu Pro Lys Arg 
                645                 650                 655     


Leu Leu Tyr His Tyr Ser Pro Ala Val Gln Asn Gly Lys Pro Gln Asn 
            660                 665                 670         


Thr Leu Val Leu Leu Leu Glu Arg Ala Thr Asp Ala Glu Lys Arg Tyr 
        675                 680                 685             


Gly Asn Leu Leu Thr Lys Ala Lys Ala Glu Gly Asn Tyr Asp Asp Phe 
    690                 695                 700                 


Val Lys Cys Asn Lys Gly Lys Gln Phe Lys Leu Gln Phe Ile Arg Lys 
705                 710                 715                 720 


Ala Trp His Leu Met Phe Phe Lys Glu Arg Tyr Met Gln Gln Ala Ala 
                725                 730                 735     


Phe Trp Gly His His Lys Arg Phe His Ile Ala Lys Asp Glu Phe Asn 
            740                 745                 750         


Asp Phe Ser Arg Phe Met Phe Ala Phe Asp Glu Val Pro His Tyr Lys 
        755                 760                 765             


Val Tyr Leu Ala Glu Met Phe Glu Lys Lys Gly Phe Phe Asp Asn Pro 
    770                 775                 780                 


Gly Phe Lys Thr Leu Phe Arg Asp Gly Val Ser Leu Asp Asp Leu Tyr 
785                 790                 795                 800 


Leu Lys Thr Lys Lys Ala Tyr Glu Ala Trp Leu Ser Lys Gln Val Ile 
                805                 810                 815     


Arg Val Gln Glu Glu Asn Lys Tyr Ala Leu Gly Asn Tyr Glu His Phe 
            820                 825                 830         


Phe Asp Asp Glu Met Phe Tyr Ile Asn Ile Ser His Phe Ile Asn Tyr 
        835                 840                 845             


Leu Glu Ala Lys Ser Gly Leu Lys Arg Asp Glu Arg Gly Leu Met Lys 
    850                 855                 860                 


Phe Thr Ala Leu Asp Asn Val Lys Phe Leu Ile Pro Glu Tyr Tyr Tyr 
865                 870                 875                 880 


Ala Asp Lys Leu Glu Lys Ala Glu Tyr Lys Thr Cys Gly Lys Leu Tyr 
                885                 890                 895     


Asn Lys Leu Lys Ser Ser Lys Leu Glu Asp Ala Leu Leu Phe Glu Met 
            900                 905                 910         


Ala Met His Tyr Leu Lys Ile Asp Lys Gln Ile Val Gln Lys Ala Lys 
        915                 920                 925             


Ser His Ala Thr Glu Ile Leu Lys Gln Asp Val Glu Phe Asp Ile Arg 
    930                 935                 940                 


Asp Leu Asn Ser Asn His Leu Tyr His Leu Met Val Pro Phe Asn Lys 
945                 950                 955                 960 


Ile Glu Ser Tyr Ile Gly Leu Ile Lys Leu Lys Glu Glu Gln Glu Glu 
                965                 970                 975     


Ser Lys Phe Lys Thr Ser Phe Leu Ala Asn Ile Val Ser Tyr Ile Glu 
            980                 985                 990         


Leu Val Lys Glu Lys Lys Glu Ile  Lys Ser Ile Tyr Lys  Thr Phe Ser 
        995                 1000                 1005             


Ala Asn  Pro Ala Lys Arg Ile  Leu Thr Phe Asp Glu  Leu Asn Lys 
    1010                 1015                 1020             


Ile Asp  Gly His Leu Ile Ser  Ser Ser Val Lys Phe  Thr Lys Leu 
    1025                 1030                 1035             


Ala Leu  Thr Leu Glu Gln Tyr  Tyr Val Asn Lys Cys  Met Leu Ser 
    1040                 1045                 1050             


Val Ile  Ala Asp His Arg Ile  Glu Tyr Gly Glu Ile  Lys Asp Leu 
    1055                 1060                 1065             


Lys Lys  Tyr Tyr Asn Thr Lys  Thr Arg Asn Lys Ala  Phe His Phe 
    1070                 1075                 1080             


Gly Val  Pro Glu Ser Ser Tyr  Asp Asn Ile Ile Ser  Lys Ile Glu 
    1085                 1090                 1095             


Gln Glu  Phe Val Arg Asn Glu  Ile Lys Ser Thr Gln  Pro His Lys 
    1100                 1105                 1110             


Phe Glu  Glu Leu Ser Lys Pro  Leu Lys Ser Ile Cys  Ser Leu Phe 
    1115                 1120                 1125             


Met Asp  Thr Ile His Asn Asn  Tyr Phe Asp Pro Ile  Glu Arg Asp 
    1130                 1135                 1140             


Gly Lys  Lys Lys His Lys Asp  Ala Glu Gln Lys Tyr  Phe Asp Thr 
    1145                 1150                 1155             


Val Ile  Ser Lys 
    1160         


<210>  1394
<211>  1171
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1394

Met Asn Leu Leu Glu Lys Thr Asn Ala Ala Glu Ser Cys Phe Asn His 
1               5                   10                  15      


Thr Ile Asn Asp Gln Lys Tyr Tyr Phe Ala Gly Tyr Leu Asn Leu Ala 
            20                  25                  30          


Gln Asn Asn Ile Lys Thr Leu Glu Lys Ala Tyr Gly Glu His Phe Leu 
        35                  40                  45              


Cys Ser Gly Asn Asn Pro Ile Ile Asn Asp Leu Thr Asn Thr Asn Ser 
    50                  55                  60                  


Leu Ile Asp Trp Asp Phe Lys Met Lys Phe Leu Ser Gln Tyr Leu Pro 
65                  70                  75                  80  


Ala Ile Ser Tyr Leu Asn Leu Glu Thr Asp Leu Asn Glu Ser Phe Glu 
                85                  90                  95      


Lys Arg Lys Lys Glu Phe Thr Lys Asn Leu Ser Phe Leu Phe Asn Ala 
            100                 105                 110         


Ile Asp Leu Leu Arg Asn Phe Tyr Ser His Tyr Tyr His Ala Pro Leu 
        115                 120                 125             


Ile Asp Glu Leu Asn Ser Glu Arg Leu Ile Phe Leu Asp Lys Ile Phe 
    130                 135                 140                 


Val Ala Val Cys Ile Asn Val Lys Lys Lys Arg Met Lys Asp Asp Lys 
145                 150                 155                 160 


Thr Lys Gln Leu Leu Lys Ala Thr Leu Ile Asp Glu Leu Asp Leu Leu 
                165                 170                 175     


Leu Lys Ala Lys Lys Glu Glu Leu Leu Lys Lys Lys Lys Glu Gly Lys 
            180                 185                 190         


Lys Val Ser Thr Asp Ala Ile Ser Met Lys Asn Ser Val Leu Asn Asp 
        195                 200                 205             


Ala Phe Asn His Leu Ile Gln Leu Glu Lys Asn Ser Lys Lys Glu Ile 
    210                 215                 220                 


Pro Gly Arg Tyr Tyr Thr Ser Leu Leu Asn Asp Asn Asn Lys Tyr Thr 
225                 230                 235                 240 


Glu Asn Gly Ile Asn Ile Ser Ile Ser Gly Leu Leu Phe Leu Leu Ser 
                245                 250                 255     


Met Phe Leu Thr Lys Lys Gln Asn Glu Asp Val Arg Ser Arg Ile Phe 
            260                 265                 270         


Gly Phe Lys Gly Thr Ile Glu Ser Asp Lys Gly Ile Ser Lys Ser Asn 
        275                 280                 285             


Asn Ser Phe Arg Asn Met Ala Thr Asn Trp Val Phe Ser Tyr Leu Ser 
    290                 295                 300                 


Phe Lys Gly Met Lys Lys Gln Leu Gly Ser Thr Phe Asn Lys Glu Ser 
305                 310                 315                 320 


Leu Leu Val Gln Ile Val Asp Glu Leu Ser Lys Val Pro His Glu Val 
                325                 330                 335     


Tyr Gln Thr Leu Ser Pro Ser Arg Gln Glu Met Phe Leu Glu Asp Met 
            340                 345                 350         


Asn Glu Tyr Leu Lys Asp Gly Asn Lys Lys His Cys Leu Glu Asp Ser 
        355                 360                 365             


Ile Val Val His Pro Val Ile Lys Lys Arg Tyr Glu Asp Lys Phe Asn 
    370                 375                 380                 


Tyr Phe Ala Ile Arg Tyr Leu Asp Glu Phe Val Asp Phe Pro Ser Leu 
385                 390                 395                 400 


Arg Phe Gln Val Asn Val Gly Asn Tyr Val His Asp Arg Arg Lys Lys 
                405                 410                 415     


Thr Ile Asp Gly Thr Asn Thr Glu Thr Asp Arg Met Val Lys Glu Glu 
            420                 425                 430         


Ile Arg Ala Phe Gly Lys Leu Ser Phe Ile Ser Lys Leu Lys Ala Asp 
        435                 440                 445             


Tyr Phe Ala Lys Asp Leu Pro Ser Asp Ile Ser Trp Glu Met Tyr Pro 
    450                 455                 460                 


Asn Pro Ser Tyr Asn Phe Ser Ala Asn Asn Ile Pro Val Tyr Ile Asp 
465                 470                 475                 480 


Leu Phe Lys Ser Ser Val Ala Gly Ala Ala Asp Val Gly Lys Asp His 
                485                 490                 495     


Lys Gly Tyr Gln Ala Lys Leu Asp Leu Asp Glu Asp Gly Lys Lys Arg 
            500                 505                 510         


Asn Arg Asn Glu Gly Lys Pro Asp Lys Lys Glu Ile Ala Glu Ile Leu 
        515                 520                 525             


Phe Gly Lys Lys Asn Lys Gln Ile Leu Phe Glu Lys Pro Thr Val Leu 
    530                 535                 540                 


Leu Ser Leu Asn Glu Leu Pro Ala Met Leu Tyr Glu Val Leu Ile Glu 
545                 550                 555                 560 


Asn Gly Asp Lys Gln Asp Ile Gly Lys Arg Ile Glu Asp Lys Ile Val 
                565                 570                 575     


Glu Lys Ile Ile Ala His Tyr Asn Leu Leu Asp Gln Tyr Asp Gly Thr 
            580                 585                 590         


Thr Glu Leu Pro Gly Ser Val Ile Pro Arg Lys Leu Arg Met Gly Gly 
        595                 600                 605             


Asn Glu Lys Ser Ile Asn Ile Asp Lys Leu Leu Arg Ala Val Lys Arg 
    610                 615                 620                 


Glu Leu Glu Ile Thr Gln Glu Lys Leu Asp Leu Ile Lys Thr Asn Gln 
625                 630                 635                 640 


Lys Lys Phe Lys Ser Lys Glu Lys Asp Glu Lys Gly Asn Ser Arg Gln 
                645                 650                 655     


His Val Phe Tyr Thr Asn Glu Leu Gly Gln Glu Ala Thr Trp Ile Ala 
            660                 665                 670         


Asn Asp Met Lys Arg Phe Met Pro Lys Glu Val Lys Glu Lys Trp Arg 
        675                 680                 685             


Gly Tyr His His Ser Asn Leu Gln Lys Leu Leu Ala Leu Tyr Asp Gln 
    690                 695                 700                 


Thr Arg Asn Glu Ala Val Lys Cys Ile Thr Cys Phe Trp Asn Phe Asp 
705                 710                 715                 720 


Gln Gln Thr Ser Trp Gly Lys Gly Ile Lys Glu Ala Phe Tyr Lys Ser 
                725                 730                 735     


Thr Phe Glu Glu Phe Tyr Lys Ala Tyr Leu Glu His Arg Met Asp Val 
            740                 745                 750         


Tyr Lys Thr Leu Glu Asn Asn Leu Ile Ala Gly Lys Gly Tyr Ser Lys 
        755                 760                 765             


Leu Phe Asn Lys Glu Lys Lys Lys Ala Phe Ile Leu Phe Asp Glu His 
    770                 775                 780                 


Leu Tyr Thr Ile Pro Asp Ile Asn Thr Gln Lys Glu Arg Leu Lys Ser 
785                 790                 795                 800 


Thr Leu Phe Ile Leu Pro Arg Gly Ile Phe Asp Ser Lys Pro Thr Phe 
                805                 810                 815     


Ile Lys Gly Ile Lys Tyr Glu Glu Asp Pro Ser Cys Phe Ala Asp Trp 
            820                 825                 830         


Tyr Gln Phe Ala Asn Ala Thr Gly Asn Gln Tyr Gln Arg Phe Tyr Asp 
        835                 840                 845             


Leu Pro Arg Ser Tyr Thr Ser Leu Phe Glu Glu Thr Lys Lys Asn Asn 
    850                 855                 860                 


Glu Gly Leu Ile Glu Asn Lys Lys Gly Leu Ser Ala Lys Glu Gln Leu 
865                 870                 875                 880 


Asp Phe Phe Lys Met Arg Gln Asp Leu Lys Ile Lys Lys Ile Lys Thr 
                885                 890                 895     


Gln Asp Leu Phe Leu Phe Met Ile Val Arg Asp Leu Tyr Lys Lys Val 
            900                 905                 910         


Phe Asp His Thr Leu Pro Leu Glu Ile Gly Leu Arg Asp Met Tyr Gln 
        915                 920                 925             


Thr Pro Ala Glu Arg Gln Ala Asn Tyr Asp Leu Ala Val Lys Gln Ser 
    930                 935                 940                 


Gln Arg Thr Glu Gly Asp Asn Ser Asp Asn Leu Tyr Asn Tyr Asn Phe 
945                 950                 955                 960 


Leu Trp Asn Leu Thr Ile Pro Phe Glu Tyr Asp Lys Ile Lys Glu Pro 
                965                 970                 975     


Gln Val Lys Leu Lys Asp Val Gly Lys Phe Tyr Lys Phe Ala Ala Asp 
            980                 985                 990         


Glu Lys Val Gln Thr Ile Leu Ser  Tyr Ser Asp Arg Glu  Trp Ser Lys 
        995                 1000                 1005             


Leu Asp  Leu Glu Lys Glu Leu  Glu Leu Met Pro Thr  Ser Tyr Glu 
    1010                 1015                 1020             


Val Ile  Arg Arg Glu Gln Leu  Leu Arg Asp Ile Gln  Gln Phe Glu 
    1025                 1030                 1035             


Lys Arg  Ile Leu Glu Asn Tyr  Pro Ser Asp Gly Asn  Ala His Pro 
    1040                 1045                 1050             


Ala Asp  Leu Glu Lys Glu Asp  Lys Asp Lys Lys Cys  Phe Pro Asn 
    1055                 1060                 1065             


Phe Asn  Leu Tyr Leu Leu Lys  Gly Ile Ile Ile Lys  Asn Asn Leu 
    1070                 1075                 1080             


Ala Ser  Glu Glu Glu Arg Gln  Trp Phe Glu Gln Val  His Leu Asp 
    1085                 1090                 1095             


Lys Thr  Pro Phe Tyr Pro Glu  Val Glu Thr Lys Ser  Ser Ile Ile 
    1100                 1105                 1110             


Gln Ser  Ala Tyr Leu Leu Leu  Leu Ile Arg Asn Lys  Met Leu His 
    1115                 1120                 1125             


Asn Gln  Leu Pro Ser Lys Gln  Asn Phe Glu Phe Met  Thr Thr Leu 
    1130                 1135                 1140             


Tyr Pro  Phe Glu Gly Tyr Glu  Ser Tyr Ser Thr Tyr  Leu Leu Phe 
    1145                 1150                 1155             


Val Thr  Lys Lys Thr Ile Glu  Cys Leu Ser Ser Ala  Met 
    1160                 1165                 1170     


<210>  1395
<211>  1103
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1395

Met Glu Asn Lys Glu Gln Asn Lys Arg Thr Trp Asp Asp Asp Pro Gln 
1               5                   10                  15      


Tyr Phe Gly Ser Tyr Leu Asn Met Ala Arg Leu Asn Ile Phe Asn Ile 
            20                  25                  30          


Ser Asn His Leu Ala Glu Lys Phe Gly Leu Thr Val Leu Asp Asp Glu 
        35                  40                  45              


Gly Lys Ile Thr Ile Ser Phe Leu Gly Asp Lys Glu Asn Lys Lys Tyr 
    50                  55                  60                  


Lys Thr Lys Gln Gly Leu Ile Tyr Ser Asn Leu Thr Arg Tyr Met Pro 
65                  70                  75                  80  


Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Glu Asn Glu Arg Asn 
                85                  90                  95      


Lys Val Lys Asn Asn Phe Gly Lys Asp Phe Asn Arg Leu Ser Asp Thr 
            100                 105                 110         


Leu Lys Ile Val Phe Lys Glu Leu Asn Glu Phe Arg Asn Asp Tyr Ser 
        115                 120                 125             


His Tyr Tyr Ser Thr Glu Lys Gln Asp Lys Arg Lys Leu Glu Ile Ser 
    130                 135                 140                 


Ser Glu Leu Asn Asp Phe Leu Ile Leu Asn Phe Ser Arg Ala Val Ser 
145                 150                 155                 160 


Tyr Thr Lys Glu Arg Phe Lys Asp Val Phe Ser Asp Glu Asp Phe Lys 
                165                 170                 175     


Ile Ala Ser Gln Thr Ile Val Val Asn Asn Asp Lys Thr Ile Thr Gln 
            180                 185                 190         


Asp Gly Ile Val Phe Leu Thr Ser Met Phe Leu Asp Arg Glu Asn Ala 
        195                 200                 205             


Phe Arg Phe Ile Asn Lys Ile Ile Gly Leu Lys Gly Thr Gln Thr Asn 
    210                 215                 220                 


Glu Phe Lys Ala Lys Arg Glu Val Leu Leu Phe Phe Cys Val Lys Leu 
225                 230                 235                 240 


Pro His Asp Lys Phe Val Ser Glu Asn Thr Glu Leu Ala Phe Ser Leu 
                245                 250                 255     


Asp Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu Tyr Asn Val 
            260                 265                 270         


Ile Thr Glu Glu Gly Lys Gln Leu Phe Arg Ser Thr Leu Glu Thr Glu 
        275                 280                 285             


Gln Ile Lys Asn Val Leu Gln Asn Ser Val Pro Asp Thr Ile Asp Asp 
    290                 295                 300                 


Tyr Glu Asn Tyr Ile Glu Ser Ile Thr Lys Lys Val Arg Asn Glu Asn 
305                 310                 315                 320 


Arg Phe Ser Tyr Phe Ala Leu Lys Tyr Ile Asp Gln Lys Glu Leu Phe 
                325                 330                 335     


Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val Leu Asp Glu 
            340                 345                 350         


Tyr Tyr Lys Gln Leu Asn Gly Lys Asp Glu Val Arg Thr Val Ile Glu 
        355                 360                 365             


Asn Ala Lys Ala Phe Gly Arg Leu Gln Asp Leu Asn Asp Glu Glu Asn 
    370                 375                 380                 


Thr Leu Lys Lys Ile Asn Thr Gly Glu Asn Lys Thr Cys Phe Asp Gln 
385                 390                 395                 400 


Phe Ala Pro His Tyr Asn Phe Asp Asp Lys Asn Asn Lys Ile Gly Ile 
                405                 410                 415     


Ser Lys Asn Glu Ile Thr Ser Lys Phe Ile Ser Lys Lys Thr Asp Lys 
            420                 425                 430         


Lys Val Lys Phe Asn Leu Leu Gln Pro Leu Pro Glu Ala Phe Leu Ser 
        435                 440                 445             


Ile His Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu Glu Gln Gly 
    450                 455                 460                 


Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn Asn Ser Lys 
465                 470                 475                 480 


Ile Ile Asn Arg Glu Phe Ile Glu Thr Ile Lys Ser Lys Leu Ser Glu 
                485                 490                 495     


Phe Asn Val Phe His Lys Arg Ser Gln Gly Arg Lys Glu Lys Arg Ala 
            500                 505                 510         


Tyr Ser Glu Gly Ala Leu Lys Tyr Leu Leu Glu Arg Lys Glu Lys Leu 
        515                 520                 525             


Asn Arg Ile Leu Ala Glu His Asn Leu Asn Val Lys Gln Ile Pro Thr 
    530                 535                 540                 


Arg Ile Leu Asp Tyr Trp Leu Asn Ile Glu Asp Val Gln Glu Lys Thr 
545                 550                 555                 560 


Ala Ile Ser Gly Arg Ile Lys Leu Met Lys Arg Asp Cys Met Asp Arg 
                565                 570                 575     


Leu Lys Ala Ile Lys Lys Lys Asn Pro Pro Lys Ile Gly Glu Met Ala 
            580                 585                 590         


Thr Phe Leu Ala Lys Asp Val Val Asp Met Ile Ile Gly Glu Glu Lys 
        595                 600                 605             


Lys Lys Lys Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu 
    610                 615                 620                 


Ala Leu Phe Ala Asp Lys Glu Lys Lys Glu Leu Phe Ile Gln Ile Cys 
625                 630                 635                 640 


Asn Glu Leu Lys Leu Asn Asn Glu Thr Asp Gly His Pro Phe Leu Lys 
                645                 650                 655     


Asn Ile Asn Leu Asn Asp Phe Arg Tyr Thr Ser Asp Leu Tyr Lys Lys 
            660                 665                 670         


Tyr Ala Glu Glu Lys Arg Leu Tyr Leu Glu Asn Asn Phe Tyr Lys Lys 
        675                 680                 685             


Gly Trp Asn Glu Lys Val Lys Lys Asp Leu Thr Met Val Val Leu Pro 
    690                 695                 700                 


His Asp Lys Ser Lys Ile Pro Phe Ser Ile Arg Gln Leu Glu Lys Glu 
705                 710                 715                 720 


Lys Thr Ser Phe Asp Lys Trp Leu Gln Tyr Val Thr Lys Gly Lys Glu 
                725                 730                 735     


Thr Thr Asp Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp 
            740                 745                 750         


Asp Thr Leu Lys Glu Leu Leu Lys Ala Glu Leu Ser Lys Asn Asn Ile 
        755                 760                 765             


Glu Phe Asp Asn Asp Ala Asn Ser Asn Glu Leu Phe Lys Thr Trp Trp 
    770                 775                 780                 


Asn Gln Cys Arg Lys Asp Asp Val Gln Glu Phe Tyr Thr Ala Glu Arg 
785                 790                 795                 800 


Glu Tyr Thr Phe Glu Lys Gly Lys Leu Thr Phe Lys Ile Asn Ser Lys 
                805                 810                 815     


Ser Lys Phe Glu Glu Tyr Ile Asn Gln Glu Phe Ile Glu Asn Ile Phe 
            820                 825                 830         


Lys Ser Lys Ser Gln Lys Arg Glu Asn Glu Asn Asn Thr Gly Arg Lys 
        835                 840                 845             


Leu Pro Pro Leu Arg Ile Lys Glu Val Thr Lys Asn Val Val Lys Lys 
    850                 855                 860                 


Ile Gly Asn Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg 
865                 870                 875                 880 


Leu Met Leu Leu Met Phe Glu Gln Leu Thr Lys Lys Glu Leu Asn Leu 
                885                 890                 895     


Lys Leu Lys Asn Thr Asp Glu Leu Leu Asn Glu Gln Ile Glu Ile Arg 
            900                 905                 910         


Glu Asn Ile Ser Gly Lys Leu Val Phe Asp Asp Phe Gly Gln Leu Ile 
        915                 920                 925             


Glu Glu Lys Lys Ser Gln Lys Thr Ile Ala Lys Asn Ile Val Glu Thr 
    930                 935                 940                 


Arg Lys Arg Lys Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Arg 
945                 950                 955                 960 


Arg Leu Pro Glu Leu Phe Glu Tyr Phe Glu Asp Glu Asp Ile Pro Met 
                965                 970                 975     


Glu Lys Ile Lys Leu Glu Leu Asp Ser Tyr Thr Lys Ala Lys Asp Ile 
            980                 985                 990         


Ile Phe Asp Leu Ala Phe Lys Leu  Glu Glu Ala Ile Ile  Lys Lys Asp 
        995                 1000                 1005             


Glu Ser  Gly Ile Lys Glu Leu  Asn Lys Asp Pro Glu  Gly Asn Ile 
    1010                 1015                 1020             


Gln Ser  Gly Asn Ile Gln His  Lys Pro Tyr Leu His  Trp Leu Leu 
    1025                 1030                 1035             


Lys Asn  Asp Leu Ile Ser Glu  Lys Glu Phe Thr Phe  Met Asn Met 
    1040                 1045                 1050             


Val Arg  Asn Thr Phe Ser His  Asn Gln Phe Pro Gln  Lys Lys Thr 
    1055                 1060                 1065             


Met Glu  Leu Phe Ile Arg His  Trp Asp Lys Gln Asn  Leu Ala Met 
    1070                 1075                 1080             


Gln Ile  Ala Glu Val Tyr Asn  Gln Lys Ile Val Glu  Ile Ala Ala 
    1085                 1090                 1095             


Lys Cys  Lys Asp Met 
    1100             


<210>  1396
<211>  1129
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1396

Met Glu Thr Asn Gln Gln Thr His Glu Asn Arg Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Asn Asn His Val Ala Thr Asp Phe Lys Arg Lys Pro 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Asp Ala Leu Leu Cys Asn Lys Thr 
    50                  55                  60                  


Ile Lys Asn Leu Asn Trp Asn His Val His Thr Arg Ala Leu Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ser Glu Ser Leu Pro Lys Asp Glu 
                85                  90                  95      


Arg Lys Asn Ser Asp Thr Glu Gly Lys Asp Phe Thr Ser Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Ser Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Asp Ser Arg Lys Leu Ile Val 
    130                 135                 140                 


Ser Pro Glu Leu Ala Asn Phe Leu Thr Ile Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Thr Tyr Thr Lys Ala Arg Met Lys Asp Val Leu Thr Asp Ala Asp Tyr 
                165                 170                 175     


Ala Leu Val Glu Asn Leu Gln Met Val Ala Thr Asp Asn Lys Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ala Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asn Gln Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Ser 
            260                 265                 270         


Ile Ile Thr Asp Lys Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Glu Asn Leu Ile Ala Asn Ser Thr Asn Asn Glu Glu Arg 
    290                 295                 300                 


Glu Arg Ile Leu Asp Glu Ile Asp Tyr Gln Asp Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg Tyr Asn Asn Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Asp Glu Lys Asn Ile Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Asn Tyr Thr Lys Gln Phe Ala Gly Glu 
        355                 360                 365             


Gln Ala Glu Arg Lys Val Leu Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asp Pro Glu Leu Ser Gln Gln Arg Ile Asp Lys Gln 
385                 390                 395                 400 


Gln Gln Thr Ala Gly Phe Glu Gln Phe Ala Pro Arg Tyr His Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Asn Ile Ala Thr Leu Thr 
            420                 425                 430         


Ala Lys Ser Lys Ala Gly Ser Lys Val Glu His Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Gln Ala Glu Glu Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Ile Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Ser Gln Leu Pro Asp Gly Trp Asn Glu Phe Asn Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asp Ser Thr Leu Arg Tyr Leu 
        515                 520                 525             


His Gln Arg Lys Thr Ile Leu Asn Thr Ile Leu Ser Lys Tyr Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Lys Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Thr Arg Leu Lys Ala Val Glu Lys His Lys Leu 
            580                 585                 590         


Asn Lys Ser Val Lys Ile Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Glu Glu Lys Lys Lys Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Thr Asn Ala Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Asn Asp Gly His Pro Phe Leu Gln Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Gln Ala Tyr Leu Ile 
        675                 680                 685             


Glu Lys Gly Asn Lys Met Val Pro Arg Leu Asn Pro Lys Thr Asn Lys 
    690                 695                 700                 


Thr Ser Lys Val Asp Glu Ser Trp Met Met Lys Gln Phe Tyr Val Lys 
705                 710                 715                 720 


Glu Trp Lys Glu Glu Ile Ala Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Ser Arg Ile Pro Phe Thr Ile Arg Gln Trp Asp Glu Lys 
            740                 745                 750         


Glu Lys Tyr Asp Leu Asn Thr Trp Leu Arg His Val Thr Val Gly Lys 
        755                 760                 765             


Asn Asn Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe Asp 
    770                 775                 780                 


Glu Ala Leu Cys Asp Leu Leu Arg Glu Gln Leu Asp Thr Lys Ile Val 
785                 790                 795                 800 


Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Ile Trp Trp 
                805                 810                 815     


Lys Thr Arg Asn Asp Asp Thr Gln Gln Phe Tyr Gln Ser Glu Arg Glu 
            820                 825                 830         


Tyr Asn Ile Tyr Asn Glu Lys Val Arg Phe Lys Ile Asp Ser Ser Ala 
        835                 840                 845             


His Phe Ala Asp Tyr Tyr Lys Asn Ala Leu Ser Arg Ala Phe Thr Arg 
    850                 855                 860                 


Leu Lys Ala Glu Arg Glu Thr Ala Arg Gln Ser Asn Lys Arg Leu Pro 
865                 870                 875                 880 


Pro Leu Glu Tyr Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile Ala 
                885                 890                 895     


Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met Ala 
            900                 905                 910         


Val Leu Met Leu Glu Arg Leu Met Asp Asn Ser Pro Asn Leu Arg Leu 
        915                 920                 925             


Ser Lys Ile Glu Thr Leu Leu Asn Asp Thr Thr Pro Ile Arg Glu Lys 
    930                 935                 940                 


Ile Ser Ala Thr Leu Ser Phe Asp Ala Ser Gly Glu Arg Ile Ser Gly 
945                 950                 955                 960 


Lys Ser Asn Pro Thr Val Thr Lys Thr Leu Val Ala Glu Arg Lys Gln 
                965                 970                 975     


Lys Asn Tyr Thr Glu Leu Arg Lys Tyr Arg Tyr Asp Arg Arg Leu Pro 
            980                 985                 990         


Glu Leu Phe Glu Tyr Val Gln Ala  Asp Glu Ile Pro Leu  Glu Trp Leu 
        995                 1000                 1005             


Leu Glu  Glu Leu Ser Ala Tyr  Asn Asn Ala Lys Gln  Gln Val Phe 
    1010                 1015                 1020             


Asp Thr  Val Phe Thr Leu Glu  Lys Lys Ile Ile Gly  Thr Asp Pro 
    1025                 1030                 1035             


Asp Gly  Leu Lys Ser Leu Phe  Thr Gly Ala Asn Gly  Glu Leu Gln 
    1040                 1045                 1050             


Thr Gly  Asn Ile Gln His Lys  Pro Tyr Val Gln Trp  Leu Thr Asn 
    1055                 1060                 1065             


Lys Gly  Leu Ile Asn Lys Glu  Glu Lys Gln Phe Ile  Asn Met Val 
    1070                 1075                 1080             


Arg Lys  Cys Phe Ser His Asn  Gln Phe Pro Gln Arg  Lys Thr Met 
    1085                 1090                 1095             


Glu Leu  Leu Ile Pro Ala Trp  Asn Glu Lys Lys Leu  Ala Leu Gln 
    1100                 1105                 1110             


Ile Ala  Thr Val Tyr Asn Gln  Leu Ile Ala Asp Leu  Thr Asn Lys 
    1115                 1120                 1125             


Ile 
    


<210>  1397
<211>  1094
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1397

Met Glu Ala Asn Glu Gln Asn Gln Glu Asn Arg Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Asn Asn His Ile Ala Ala Asp Phe Gly Gln Ala Val 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ser Gly Phe Leu Cys Asn Lys Glu 
    50                  55                  60                  


Ile Lys Lys Leu Asn Trp Asn His Ile Tyr Ala Lys Thr Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ile Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Val Asn Ser Asp Lys Glu Gly Lys Asp Phe Ala Ala Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Ser Glu Leu Gln Asp Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Glu Asn Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Ala Glu Leu Thr Asp Met Leu Thr Ile Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Thr Asp Ala Asp Tyr 
                165                 170                 175     


Glu Leu Val Glu Thr Lys Gln Val Val Thr Thr Gly Asn Ile Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Met Phe Leu Glu Arg Glu His 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asn Leu Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Gly 
            260                 265                 270         


Val Ile Thr Asp Glu Glu Lys Met Gln Phe Arg Pro Glu Leu Asp Glu 
        275                 280                 285             


Leu Asp Ile Glu Lys Leu Ile Ala Asn Ser Thr Asn Asp Asp Glu Arg 
    290                 295                 300                 


Glu Arg Ile Leu Asp Glu Ile Gly Tyr Glu Glu Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg Tyr Asn Asn Arg Phe Pro Tyr Phe Ala Met Arg 
                325                 330                 335     


Phe Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Arg Tyr Thr Lys Gln Leu Ala Gly Glu 
        355                 360                 365             


Gln Thr Glu Arg Val Val Gln Glu Asn Val Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asp Pro Glu Leu Ile Gln Gln Lys Ile Asp Asn Gln 
385                 390                 395                 400 


Gln Arg Thr Asp Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Ile Ala Ile Leu Ile 
            420                 425                 430         


Pro Lys Ser Lys Pro Glu Ser Lys Val Gly Asn Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Asp Tyr Leu Gln Lys Gly Lys Ala Glu Glu Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Ile Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Leu Lys Leu Pro Ala Asn Trp Asn Glu Phe Ala Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asp Ala Ala Met Glu Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Asp Val Leu Ile Thr Tyr Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Asp Val Glu Asp Asn Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Leu Glu Lys His Lys Leu 
            580                 585                 590         


Asp Lys Ser Val Lys Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Met Val Ser Lys Glu Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Ala Asp Thr Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Val Leu Glu Gly Asp Gly His Pro Phe Leu Thr Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Glu Leu Tyr Met Asn 
        675                 680                 685             


Ala Lys Val Gln Tyr Leu Ile Gln Phe Tyr Lys Pro Ser Lys Asp Lys 
    690                 695                 700                 


Val Asp Lys Arg Gly Arg Pro Thr Thr Glu Val Lys Leu Pro Pro Leu 
705                 710                 715                 720 


Asp Lys Arg Ser Asn Ile Pro Phe Thr Ile Arg Gln Trp Asp Glu Lys 
                725                 730                 735     


Glu Lys Tyr Asn Leu Asn Ala Trp Leu Arg Asn Val Thr Val Gly Lys 
            740                 745                 750         


Asn Thr Lys Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe 
        755                 760                 765             


Asp Glu Thr Leu Cys Asp Leu Leu Ser Gln Gln Leu Asp Ala Arg Thr 
    770                 775                 780                 


Val Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Leu Trp 
785                 790                 795                 800 


Trp Lys Thr Arg Asp Asp Ala Thr Gln Asp Phe Tyr Gln Ser Glu Arg 
                805                 810                 815     


Glu Tyr Asp Ile Tyr Glu Glu Lys Val Glu Phe Lys Ile Asp Ser Ser 
            820                 825                 830         


Gly His Phe Ala Asp Tyr Tyr Lys Lys Ala Leu Ser Lys Ala Tyr Asn 
        835                 840                 845             


Arg Leu Lys Ala Glu Arg Glu Ile Ala Arg Arg Thr Asn Lys Arg Leu 
    850                 855                 860                 


Pro Pro Ile Glu His Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile 
865                 870                 875                 880 


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
                885                 890                 895     


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asp Ser Gly Asn Leu Lys 
            900                 905                 910         


Leu Ser Thr Ile Lys Thr Ser Leu Asn Asn Thr Thr Gln Ile Lys Gln 
        915                 920                 925             


Lys Ile Leu Asn Lys Thr Ile Val Ala Glu Arg Lys Gln Lys Asn Tyr 
    930                 935                 940                 


Thr Glu Leu Arg Lys Tyr Val His Asp Arg Arg Leu Pro Asn Leu Phe 
945                 950                 955                 960 


Glu Tyr Val Glu Ala Asp Glu Ile Leu Leu Glu Trp Leu Leu Asp Glu 
                965                 970                 975     


Leu Met Ala Tyr Asn Ala Ala Lys Gln Gln Val Phe Asp Thr Ile Phe 
            980                 985                 990         


Met Leu Glu Lys Arg Ile Ile Glu  Thr Asp Pro Gln Glu  Leu Lys Ser 
        995                 1000                 1005             


Leu Phe  Thr Asn Glu Lys Gly  Gln Val Gln Thr Gly  Asn Ile Gln 
    1010                 1015                 1020             


His Lys  Pro Tyr Val Gln Trp  Leu Lys Asn Lys Gly  Leu Ile Asn 
    1025                 1030                 1035             


His Asn  Glu Lys Leu Phe Ile  Asn Met Val Arg Asn  Cys Phe Ser 
    1040                 1045                 1050             


His Asn  Gln Phe Pro Gln Arg  Glu Thr Met Glu Leu  Leu Ile Ser 
    1055                 1060                 1065             


Glu Trp  Gly Ala Gly Lys Ile  Ala Thr Gln Ile Leu  Thr Val Tyr 
    1070                 1075                 1080             


Asn Gln  Leu Ile Thr Asn Ile  Ile Asn Lys Ile 
    1085                 1090                 


<210>  1398
<211>  1047
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1398

Met Glu Glu Gln Phe Leu Gln Lys Glu Arg Asn Met Gly Asp Asn Pro 
1               5                   10                  15      


Tyr Tyr Phe Cys His Phe Ile Asn Met Ala His His Asn Val Asn Leu 
            20                  25                  30          


Ile Leu Glu Glu Ile Tyr Asn Ser Val Tyr Glu Lys Tyr Thr Gln Asp 
        35                  40                  45              


Lys Glu Glu Asn Ile Lys Ala Ile Cys Asn Ser Met Ile Ser Lys Ser 
    50                  55                  60                  


Arg Lys Asn Pro Asp Glu Lys Ala Lys Met Met Asn Met Cys Ile Arg 
65                  70                  75                  80  


His Phe Pro Phe Leu Asp Tyr Tyr Lys Glu Lys Asp Gln Asn Ser Asp 
                85                  90                  95      


Val Leu Thr Ile Leu Leu Asn Gln Phe Leu Val Pro Leu His Gly Leu 
            100                 105                 110         


Arg Asn Gln Phe Ser His Tyr Lys His Pro Gln Glu Ala Tyr Cys Ile 
        115                 120                 125             


Ser Gly Phe Asp Leu Leu Phe Glu Gln Ala Lys Thr Gly Ala Gln Met 
    130                 135                 140                 


Arg Met Lys Tyr Ser Asp Glu Asp Ile Ser Lys Val Lys Ser Lys Val 
145                 150                 155                 160 


Val Asn His Asp Ser Ile Leu Thr Glu Arg Gly Ile Leu Phe Phe Ile 
                165                 170                 175     


Cys Leu Phe Leu Asp Lys Arg Asn Ile Tyr Leu Phe Leu Ser Lys Ile 
            180                 185                 190         


Lys Gly Phe Arg Asp Arg Arg Pro Asp Glu Lys Tyr Lys Ser Ala Thr 
        195                 200                 205             


Leu Glu Val Phe Ser Gln Tyr Tyr Cys His Val Pro Tyr Arg Lys Leu 
    210                 215                 220                 


Asp Ser Ser Asp Val Ala Leu Asp Met Leu Asn Glu Leu Asn Arg Cys 
225                 230                 235                 240 


Pro Lys Ala Leu Tyr Asp Val Leu Ser Asp Glu Asp Arg Glu Arg Phe 
                245                 250                 255     


Ile Val Asp Asn Val Glu Asn Ala Asp Asn Arg Asp Glu Ile Ser Asp 
            260                 265                 270         


Glu Asp Asp Glu Glu Met Pro Arg Ser Val Met Lys Arg Ser Asp Asp 
        275                 280                 285             


Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Glu Lys Gln Asn Asn Leu 
    290                 295                 300                 


Asp Glu Ile Ser Phe His Leu Tyr Leu Gly Arg Lys Glu Ala Lys Pro 
305                 310                 315                 320 


Ala His Glu Lys Val Ile Asn Gly Glu Met Arg Thr His Lys Ile Leu 
                325                 330                 335     


Lys Asp Ile His Val Phe Gly Arg Leu Glu Asn Tyr Arg Asn Glu Glu 
            340                 345                 350         


Ile Cys Asn Ala Ile Lys Asn Arg Glu Asp Ile Glu Phe Tyr Ala Pro 
        355                 360                 365             


Ser Tyr Arg Ile Val Glu Asn Arg Ile Gly Leu Leu Leu Arg Arg Gln 
    370                 375                 380                 


Asn Asp Phe Thr Leu Glu Glu Ala Asn Glu Glu Lys Ile Phe Glu Gly 
385                 390                 395                 400 


Asn Leu Cys Pro Asp Val Ile Leu Ser Thr His Glu Leu Gly Ala Leu 
                405                 410                 415     


Phe Phe Tyr Asn Tyr Leu His Lys Lys Gly Trp Ile Glu Ser Ala Pro 
            420                 425                 430         


Tyr Leu Tyr Ile Arg Asn Phe Ile Ser Asp Phe Lys Arg Phe Ile Glu 
        435                 440                 445             


Asp Ile Lys Asn Gly Lys Leu Thr Pro Val Glu Ser Glu Asp Asp Phe 
    450                 455                 460                 


Tyr Leu Ile Lys Lys Lys Lys Arg Asp Glu Thr Lys Asp Asn Asp Lys 
465                 470                 475                 480 


Lys Ser Ile Ala Val Gln Glu Arg Arg Arg Glu Lys Leu Lys Glu Lys 
                485                 490                 495     


Leu Lys Gly Tyr His Leu Glu Pro Asp Trp Ile Pro Asp Ala Cys Arg 
            500                 505                 510         


Glu Tyr Met Leu Gly Tyr Lys Ala Asp Gln Lys Asp Tyr Tyr Thr Lys 
        515                 520                 525             


Gln Arg Phe Cys Ser Met Lys Lys Glu Thr Asp Ser Arg Ile Lys Gln 
    530                 535                 540                 


Ile Glu Ala Ile Arg Lys Arg Glu Asp Asn Ser Ile Ile Arg Gln Thr 
545                 550                 555                 560 


Arg Val Gly Glu Ile Ala Gln Glu Leu Ala Arg Asp Ile Val Phe Leu 
                565                 570                 575     


Ile Pro Pro Tyr Lys Asn Glu Lys Gly Ala Asp Thr Lys Ile Asn Asn 
            580                 585                 590         


Met Glu Phe Asp Val Leu Gln Lys Met Leu Ala Tyr Phe Pro Leu Asn 
        595                 600                 605             


Lys Lys Asp Ile Tyr Pro Phe Leu Lys Asn Ile Arg Asn Trp Asp Lys 
    610                 615                 620                 


His Pro Phe Leu Lys Tyr Thr Leu His Thr Glu His Gln Ser Leu Leu 
625                 630                 635                 640 


Asp Phe Tyr Gln Asp Tyr Leu Asn Cys Lys Lys Arg Trp Ile Ser Lys 
                645                 650                 655     


Asn Ile Arg Tyr Asp Lys Gln Lys Gly Asn Tyr Leu Val Asp Ala Asn 
            660                 665                 670         


Lys Thr Glu Gln Glu Cys Arg Tyr Phe Leu Lys Thr Asp Lys Leu Arg 
        675                 680                 685             


Thr Ala Lys Glu Lys Glu Tyr Phe Glu Glu Pro Asp Lys Pro Val Tyr 
    690                 695                 700                 


Leu Pro Thr Gly Phe Phe Val Asp Pro Ile Val Glu Ala Met Arg Lys 
705                 710                 715                 720 


Asn Gly Tyr Glu Leu Lys Glu Asn Ser Asn Ile Val Gly Cys Leu Lys 
                725                 730                 735     


Ile Tyr Phe Val Ser Lys Ile Gln Pro Met Tyr Asp Leu Ser Arg Tyr 
            740                 745                 750         


Tyr Thr Tyr Tyr Asp Gly Lys Glu Glu Arg Ser Met Gln Leu Asp Asp 
        755                 760                 765             


Leu Lys Val Phe Ile Lys Glu Lys Phe Gly Asn Lys Arg Thr Asp Asp 
    770                 775                 780                 


Asn Thr Ile Arg Phe Leu Lys Lys Ala Ala Lys Arg Ile Arg Glu Asn 
785                 790                 795                 800 


Glu Ser Glu Ile Leu Val Arg Gln Met Asp Asp Cys Ala Leu Phe Leu 
                805                 810                 815     


Met Val Asn Asp Leu Leu Glu Gly Gly Lys Phe Asn Asp Glu Asp Ile 
            820                 825                 830         


Glu Asn Ile Gly Tyr Asn Lys His His Asn Leu Leu Asp His Glu Tyr 
        835                 840                 845             


Asp Met Cys Glu Thr Ile Tyr Gly Arg Lys Val Thr Ala Arg Leu Pro 
    850                 855                 860                 


Ile Lys Arg Tyr Gly Glu Phe Arg Arg Phe Met Lys Asp Arg Arg Leu 
865                 870                 875                 880 


Gln Asn Leu Val Lys Tyr Tyr Pro Gly Asp His Glu Thr Pro Ile Pro 
                885                 890                 895     


Ser Gly Ile Pro Glu Ser Gly Lys Ala Met Glu Lys Asn Lys Lys Tyr 
            900                 905                 910         


Thr Tyr Ser Asn Leu Cys Asp Glu Leu Glu Ile Tyr Asp Lys Glu Arg 
        915                 920                 925             


Asp Asn Val Leu Asn Leu Ile Tyr Glu Val Asp Lys Ile Leu Val Asp 
    930                 935                 940                 


His Phe Pro Asp Lys Ile Met Lys Glu Glu Asp Gly Tyr Tyr Glu His 
945                 950                 955                 960 


Tyr His Cys Leu Asp Phe Ala Lys Lys Glu Phe Gly Leu Glu Ser Asp 
                965                 970                 975     


Val Glu Leu Leu Ser Gln Asp Asn Phe Lys Asp Leu Arg Asn Ala Leu 
            980                 985                 990         


Tyr His Asn Gln Ile Pro Tyr Asn  Asp Trp Val Ala Asp  Lys Ile Ser 
        995                 1000                 1005             


Lys Asp  Thr Glu Glu Pro Met  Tyr Val Arg Arg Ile  Phe Ser Phe 
    1010                 1015                 1020             


Ile Arg  Thr Val Tyr Ser Arg  Leu Leu Asp Gln Ile  Lys Ile Lys 
    1025                 1030                 1035             


Ile Glu  Lys Asp Glu Tyr Lys  Cys Lys 
    1040                 1045         


<210>  1399
<211>  1129
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1399

Met Glu Thr Asn Gln Gln Thr His Glu Asn Arg Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Asn Asn His Ile Ala Thr Asp Phe Lys Gln Ala Thr 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ala Ala Phe Leu Cys Asn Lys Thr 
    50                  55                  60                  


Ile Lys Asn Leu Asn Trp Asn His Val His Thr Arg Ala Val Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ser Glu Ser Leu Pro Lys Asp Glu 
                85                  90                  95      


Arg Glu Asn Ser Asp Thr Glu Gly Lys Asp Phe Thr Ser Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Ser Glu Leu Gln Asp Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Asp Ser Arg Lys Leu Ile Val 
    130                 135                 140                 


Ser Pro Glu Leu Ala Asn Phe Leu Thr Val Asn Phe Gln Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Ala Arg Met Lys Asp Val Leu Thr Asp Thr Asp Tyr 
                165                 170                 175     


Ala Leu Val Glu Asn Leu Gln Met Val Ala Pro Asp Asn Lys Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ala Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Thr Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asn Leu Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Ser 
            260                 265                 270         


Val Ile Thr Asp Lys Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Asp Asp Glu Arg 
    290                 295                 300                 


Glu Thr Ile Leu Asp Glu Ile Asp Tyr Gln Asp Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg Tyr Ser Asp Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Asp Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Asn Tyr Thr Lys Gln Phe Ala Gly Glu 
        355                 360                 365             


Gln Ala Glu Arg Lys Val Leu Glu Asn Ala Asn Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asp Pro Glu Leu Ile Gln Gln Arg Ile Asp Lys Gln 
385                 390                 395                 400 


Gln His Thr Ala Gly Phe Asp Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Thr Lys Glu Asn Ile Ala Thr Leu Ile 
            420                 425                 430         


Ala Lys Ser Lys Ala Ser Ser Lys Val Glu His Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Gln Ala Glu Glu Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Ile Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Ser Gln Leu Pro Ala Asn Trp Asp Glu Phe Ser Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asp Ser Thr Leu Lys Tyr Leu 
        515                 520                 525             


Arg Gln Arg Lys Thr Thr Leu Asn Thr Ile Leu Ser Lys Ser Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Lys Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Thr Arg Leu Lys Ala Val Glu Lys His Lys Leu 
            580                 585                 590         


Asn Lys Ser Val Lys Ile Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Glu Glu Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Ala Asn Ala Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Phe Glu Asn Gly Gly His Pro Phe Leu Gln Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Gln Ala Tyr Leu Val 
        675                 680                 685             


Glu Lys Gly Asn Lys Met Val Pro Arg Leu Asn Pro Lys Thr Asn Lys 
    690                 695                 700                 


Thr Ser Lys Val Asp Glu Ser Trp Met Met Lys Gln Phe Tyr Val Lys 
705                 710                 715                 720 


Glu Trp Lys Glu Glu Ile Ala Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Ser Arg Ile Pro Phe Thr Ile Arg Gln Trp Asp Glu Lys 
            740                 745                 750         


Glu Lys Tyr Asp Leu Asn Val Trp Leu Gln His Val Thr Val Gly Lys 
        755                 760                 765             


Asn Lys Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe Asp 
    770                 775                 780                 


Glu Ala Leu Cys Asn Leu Leu Arg Glu Gln Leu Asp Thr Lys Ile Val 
785                 790                 795                 800 


Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Ile Trp Trp 
                805                 810                 815     


Lys Thr Arg Asn Asp Asp Thr Gln Gln Phe Tyr Gln Ser Glu Arg Glu 
            820                 825                 830         


Tyr Asp Ile Tyr Asn Glu Lys Val Arg Phe Lys Ile Asp Ser Ser Thr 
        835                 840                 845             


His Phe Ala Asp Tyr Tyr Lys Asn Ala Leu Ser Arg Ala Tyr Thr Arg 
    850                 855                 860                 


Leu Lys Ala Glu Arg Glu Thr Ala Arg Gln Thr Asn Lys Arg Leu Pro 
865                 870                 875                 880 


Pro Leu Glu Tyr Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile Ala 
                885                 890                 895     


Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met Ala 
            900                 905                 910         


Val Leu Met Leu Glu Gln Leu Met Asp Asn Ser Pro Asn Leu Arg Leu 
        915                 920                 925             


Ser Lys Ile Glu Thr Leu Leu Asn Asp Thr Thr Pro Ile Ser Glu Lys 
    930                 935                 940                 


Ile Ser Ala Lys Leu Ser Phe Asp Ala Ser Gly Glu Arg Ile Thr Asp 
945                 950                 955                 960 


Lys Ser Asn Pro Thr Ala Thr Lys Thr Leu Val Ala Glu Arg Lys Gln 
                965                 970                 975     


Lys Asn Tyr Thr Glu Leu Gln Lys Tyr Arg Tyr Asp Arg Arg Leu Pro 
            980                 985                 990         


Glu Leu Phe Glu Tyr Val Gln Ala  Asp Glu Ile Pro Leu  Glu Trp Leu 
        995                 1000                 1005             


Leu Asp  Glu Leu Ser Ala Tyr  Asn Ser Ala Lys Gln  Gln Val Phe 
    1010                 1015                 1020             


Asp Thr  Val Phe Ala Leu Glu  Lys Lys Ile Ile Gln  Thr Glu Pro 
    1025                 1030                 1035             


Asp Glu  Leu Lys Ser Leu Phe  Thr Gly Ala Asn Gly  Glu Leu Gln 
    1040                 1045                 1050             


Thr Gly  Asn Ile Gln His Lys  Pro Tyr Val Gln Trp  Leu Thr Asn 
    1055                 1060                 1065             


Lys Gly  Leu Ile Asn Lys Glu  Glu Lys Gln Phe Ile  Asn Met Val 
    1070                 1075                 1080             


Arg Lys  Cys Phe Ser His Asn  Gln Phe Pro Gln Arg  Thr Thr Met 
    1085                 1090                 1095             


Glu Leu  Leu Ile Pro Ala Trp  Asn Glu Lys Lys Leu  Ala Leu Gln 
    1100                 1105                 1110             


Ile Ala  Thr Val Tyr Asn Gln  Leu Ile Ala Asp Leu  Thr Asp Lys 
    1115                 1120                 1125             


Ile 
    


<210>  1400
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1400

Met Glu Thr Lys Gln Gln Val Gly Lys Gly Ile Ser Tyr Asp His Arg 
1               5                   10                  15      


Arg Pro Asp Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asp Gly Val Ile Gln Glu Phe Ala Met Arg Leu Asn Arg 
        35                  40                  45              


Glu Tyr Asp Pro Glu Asn Lys Asn Gln Ser Leu Phe Ser Tyr Phe Asn 
    50                  55                  60                  


Ile Asn Ala Ser Phe Thr Asp Trp Glu Arg Gly Val Asn Ile Leu Lys 
65                  70                  75                  80  


Glu Tyr Trp Pro Met Met Glu Phe Ile Asp Arg Pro Ala Thr Asp Lys 
                85                  90                  95      


Gln Phe Glu Ala Glu Lys Pro Glu Asn Arg Glu Ala Ala Lys Arg Lys 
            100                 105                 110         


Tyr Phe Leu Ala Thr Leu Gly Ala Leu Leu Thr Ser Ile Lys Asp Leu 
        115                 120                 125             


Arg His Tyr Tyr Thr His Tyr Tyr His Pro Pro Val His Leu Asn Asp 
    130                 135                 140                 


Asp Leu Phe Leu Phe Leu Asp His Ala Leu Leu Tyr Thr Ala Phe Asp 
145                 150                 155                 160 


Val Lys Lys Thr Lys Met Lys Asp Asp Lys Thr Arg Gln Leu Leu Asn 
                165                 170                 175     


Gln Asn Leu Ser Leu Glu Leu Glu Lys Leu Lys Lys Leu Lys Val Glu 
            180                 185                 190         


Glu Leu Lys Lys Lys Lys Glu Lys Gly Ile Lys Val Asn Leu Gln Asp 
        195                 200                 205             


Glu Lys Gly Ile Leu Asn Ala Ile Tyr Asn Asp Ala Phe Ala His Ile 
    210                 215                 220                 


Ile Thr Lys Glu Lys Asp Ser Asp Lys Asp Lys Leu Glu Thr Arg Tyr 
225                 230                 235                 240 


Lys Ser Ile Leu Pro Gln Asp Glu Ala Ala Glu Thr Gly Ile Asn Ile 
                245                 250                 255     


Ser Ile Ser Gly Leu Ile Phe Leu Leu Ser Leu Phe Leu Ser Arg Lys 
            260                 265                 270         


Glu Ile Glu Gln Leu Lys Ser Asn Ile Glu Gly Tyr Lys Gly Lys Val 
        275                 280                 285             


Leu Asn Ile Glu Thr Glu Val Asp Arg Lys His Asn Ser Leu Lys Tyr 
    290                 295                 300                 


Met Ala Thr His Trp Val Phe Ser Ile Leu Ala Phe Lys Gly Leu Lys 
305                 310                 315                 320 


Gln Arg Leu Thr Asn Ser Phe Glu Lys Glu Ser Leu Leu Ile Gln Met 
                325                 330                 335     


Met Asp Glu Leu Asn Lys Val Pro Asp Glu Leu Tyr Gln Thr Leu Ser 
            340                 345                 350         


Glu Thr Ala Lys Lys Glu Phe Leu Glu Asp Ile Asn Glu Tyr Val Ser 
        355                 360                 365             


Glu Gly Asp Asp Asn Glu Lys Ala Thr Tyr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Ser Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gln Phe Pro Thr Leu Lys Phe Gln Ile Phe Val Gly 
                405                 410                 415     


Gln Tyr Leu His Asp Asn Arg Pro Lys Thr Leu Ala Ser Asn Gly Met 
            420                 425                 430         


Thr Ala Gln Arg Met Ile Lys Glu Lys Ile Asn Leu Phe Gly Asn Leu 
        435                 440                 445             


Ser Glu Val Thr Lys His Lys Ser Asp Phe Phe Glu Lys Glu Ser Ala 
    450                 455                 460                 


Ala Gln Gly Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Trp Ala Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Val Tyr Ile Asp Met Ile Gly Lys Glu Gly Lys Ala 
                485                 490                 495     


Lys Glu Ile Gln Val Gln Ile Asn Lys Tyr Arg Lys Gln Leu Asn Pro 
            500                 505                 510         


Ala Pro Gln Arg Asp Lys Arg Ile Ser Lys Lys Glu Ile Ile Glu Gln 
        515                 520                 525             


Leu Tyr Lys Glu Lys Val Val Tyr Gly Asp Pro Thr Leu Met Leu Ser 
    530                 535                 540                 


Ala Asn Glu Leu Met Ala Leu Leu Tyr Glu Leu Ile Val Asn Gly Lys 
545                 550                 555                 560 


Ser Gly Ala Glu Leu Glu Asn Lys Ile Val Glu Gln Ile Ile Ala Arg 
                565                 570                 575     


Tyr Glu Gln Ile Glu Ala Tyr Asp Pro Thr Thr Gln Gln Leu Pro Thr 
            580                 585                 590         


Asn Gln Met Pro His Lys Leu Gln Lys Ser Arg Lys Asp Ser Lys Val 
        595                 600                 605             


Thr Asp Thr Asp Lys Leu Leu Lys Thr Ile Asp Lys Glu Ile Asp Glu 
    610                 615                 620                 


Gly Asn Lys Lys Leu Glu Leu Ile Ala Cys His Arg Lys Glu Trp Glu 
625                 630                 635                 640 


Glu Ala Glu Gln Arg Lys Lys Ser Gly Lys Arg Asn Asn Pro Gly Thr 
                645                 650                 655     


Lys Ser Arg Lys His Leu Phe Tyr Ala Ser Glu Met Gly Glu Glu Ala 
            660                 665                 670         


Thr Trp Ile Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Pro Ala Arg 
        675                 680                 685             


Ala Glu Trp Lys Gly Thr His His Ser Glu Leu Gln Arg Leu Leu Ala 
    690                 695                 700                 


Phe Tyr Ser Thr Gln Arg Leu Glu Ala Trp Gln Leu Val Glu Ser Val 
705                 710                 715                 720 


Trp Thr Ala Asn Thr His Ser Phe Trp Glu Glu Asn Phe Lys Glu Ala 
                725                 730                 735     


Phe Tyr Lys Pro Glu Phe Glu Asn Phe Tyr Gly Ala Tyr Ile Glu Ile 
            740                 745                 750         


Arg Thr Lys Ile Leu Thr Thr Cys Arg Ser Ile Leu Glu Asn Asn Pro 
        755                 760                 765             


Glu Ala Thr Met Asn Asn Asp Thr Glu Lys Glu Trp Asp Lys Val Phe 
    770                 775                 780                 


Thr Leu Phe Asp Lys Arg Leu Tyr Arg Thr Ser Thr Thr Asp Glu Gln 
785                 790                 795                 800 


Lys Lys Gln Leu Leu Thr Lys Pro Phe Ala Phe Pro Arg Gly Leu Phe 
                805                 810                 815     


Asp Asp Lys Pro Thr Phe Leu Pro Gly Ser Lys Pro Asn Glu Asn Pro 
            820                 825                 830         


Glu Arg Phe Ala Ala Trp Tyr Ser Tyr Gly Tyr Thr Tyr Ser Gly Lys 
        835                 840                 845             


Phe Gln Ser Phe Tyr Asp Met Pro Arg Asn Tyr Ser Asp Trp Tyr Lys 
    850                 855                 860                 


Lys Leu Lys Glu Asp Gly Lys Leu Pro Arg Leu Asp Lys Lys Thr Glu 
865                 870                 875                 880 


Gln Glu Lys Ile Leu Arg Phe Arg Met Asp Cys Asp Leu Asn Ile Lys 
                885                 890                 895     


His Ile Arg Phe Gln Asp Ile Tyr Val Lys Leu Met Val Asp Ser Leu 
            900                 905                 910         


Tyr Lys Ala Val Phe Gly Gln Gln Pro Glu Phe Asp Leu Ser His Leu 
        915                 920                 925             


Tyr Asp Thr Arg Ser Glu Arg Tyr Glu Asn Asn Thr Ile Ala Gln Arg 
    930                 935                 940                 


Gln Lys Ser Arg Gln Glu Gly Asp Asn Ser Asp Asn Ala Ile Asn Glu 
945                 950                 955                 960 


Asn Tyr Val Trp Asn Lys Thr Phe Ala Ile Ser Leu Tyr Asn Gly Arg 
                965                 970                 975     


Ile Thr Glu Ser Gln Val Lys Leu Lys Asp Val Gly Lys Phe Arg Arg 
            980                 985                 990         


Phe Ala Thr Asp Pro Arg Val Gln  Thr Leu Ile Ser Tyr  Asp Asp Thr 
        995                 1000                 1005             


Arg Thr  Trp Thr Lys Leu Glu  Ile Glu Asn Glu Leu  Asp Asn Lys 
    1010                 1015                 1020             


Ala Asp  Ala Tyr Glu Pro Ile  Arg Arg Thr Gln Ser  Leu Lys Ala 
    1025                 1030                 1035             


Ile Gln  Gln Leu Glu Lys Asn  Ile Leu Lys Lys Asn  Gly Phe Asn 
    1040                 1045                 1050             


Gly Lys  Gln His Pro Glu Glu  Leu Lys His Asn Gly  Asn Pro Asn 
    1055                 1060                 1065             


Phe Arg  Lys Tyr Ile Ala Asn  Gly Leu Leu Lys His  Arg Thr Asp 
    1070                 1075                 1080             


Ile Arg  Gln Glu Glu Leu Ala  Leu Ile Ser Asp Thr  Glu Phe Gln 
    1085                 1090                 1095             


Glu Ile  Gly Leu Glu Arg Ile  Arg Gln Thr Asn Pro  Leu Ile Gln 
    1100                 1105                 1110             


Lys Ala  Tyr Leu Leu Ile Leu  Leu Arg Asn Lys Phe  Gly His Asn 
    1115                 1120                 1125             


Gln Leu  Pro Asp Gln Glu His  Phe Arg Leu Met Arg  Ser Ile Tyr 
    1130                 1135                 1140             


Pro Tyr  Asn Gln Gln Glu Ser  Tyr Ser Ala Tyr Phe  Asn His Val 
    1145                 1150                 1155             


Ile Thr  Gln Ile Ile Glu Glu  Leu Asn Thr 
    1160                 1165             


<210>  1401
<211>  985
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1401

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Lys His Leu 
145                 150                 155                 160 


Arg Asn Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys Gly Tyr 
                165                 170                 175     


Ala Phe Phe Ile Ser Lys Phe Leu Glu Arg Lys Tyr Ser Tyr Leu Phe 
            180                 185                 190         


Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln Tyr Arg 
        195                 200                 205             


Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro Val Glu 
    210                 215                 220                 


Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu Asp Ile 
225                 230                 235                 240 


Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr Leu Glu 
                245                 250                 255     


Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr Asp Ala 
            260                 265                 270         


Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe Arg Ser 
        275                 280                 285             


Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala Asp Phe 
    290                 295                 300                 


Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His Asn Gly 
305                 310                 315                 320 


Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr Ile Asn 
                325                 330                 335     


Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser Ala Lys 
            340                 345                 350         


Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser Thr Asp 
        355                 360                 365             


Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln Ser Thr 
    370                 375                 380                 


Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val Leu Pro 
385                 390                 395                 400 


Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala Lys Met 
                405                 410                 415     


Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala Met Leu 
            420                 425                 430         


Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His Cys Pro 
        435                 440                 445             


Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser Thr Lys 
    450                 455                 460                 


Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg Val Met 
465                 470                 475                 480 


Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu Arg Ile 
                485                 490                 495     


Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile Leu Lys 
            500                 505                 510         


Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp Leu Gln 
        515                 520                 525             


Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn Phe Gln 
    530                 535                 540                 


Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn Asp Leu 
545                 550                 555                 560 


Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn Pro His 
                565                 570                 575     


Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile Glu Phe 
            580                 585                 590         


Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg Ile Gln 
        595                 600                 605             


Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro Leu Arg 
    610                 615                 620                 


Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu Ala Ile 
625                 630                 635                 640 


Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys Leu Lys 
                645                 650                 655     


Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu Lys Ser 
            660                 665                 670         


Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg Thr Tyr 
        675                 680                 685             


Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn Tyr Arg 
    690                 695                 700                 


Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser Tyr Leu 
705                 710                 715                 720 


Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro Ser Lys 
                725                 730                 735     


Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp Arg Leu 
            740                 745                 750         


Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile Ile Arg 
        755                 760                 765             


Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys Glu Tyr 
    770                 775                 780                 


Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu Glu Asn 
785                 790                 795                 800 


Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp Leu Asn 
                805                 810                 815     


Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr Gly Lys 
            820                 825                 830         


Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn Lys Val 
        835                 840                 845             


Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val Lys Ile 
    850                 855                 860                 


Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu Glu Ala 
865                 870                 875                 880 


Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala Met Val 
                885                 890                 895     


Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr Tyr Asp 
            900                 905                 910         


Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln Lys Ile 
        915                 920                 925             


Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His Asp Lys 
    930                 935                 940                 


Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Leu Val Tyr Ala 
945                 950                 955                 960 


Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile Lys Leu 
                965                 970                 975     


Glu Asp Leu Ser Asn Asp Ser Ser Ala 
            980                 985 


<210>  1402
<211>  1175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1402

Met Thr Glu Gln Asn Glu Lys Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Phe Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Ala His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Lys Tyr Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Glu Lys Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Ala Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln Leu Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Phe Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Glu Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Gly Glu Ile Asp Thr Leu Asp 
    530                 535                 540                 


Arg Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Gly Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Leu Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Asp Leu Glu Ala Trp Ser His Ser Ala Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Ala Gly Ile Glu Asn Ala Ser Arg Glu Asn 
    850                 855                 860                 


Lys Lys Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Glu Thr 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Lys Ala Asp Lys Ile Asn Ile Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Ala Lys Glu His Pro Tyr Leu Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asp Ile Arg Thr 
945                 950                 955                 960 


Asp Val Gln Glu Gln Gly Ser Leu Asn Val Leu Asn His Val Lys Pro 
                965                 970                 975     


Met Arg Leu Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val 
            980                 985                 990         


His Lys Glu Gln Ala Pro Leu Ala  Thr Val Tyr Ile Glu  Glu Arg Asp 
        995                 1000                 1005             


Thr Lys  Leu Leu Lys Gln Gly  Asn Phe Lys Ser Phe  Val Lys Asp 
    1010                 1015                 1020             


Arg Arg  Leu Asn Gly Leu Phe  Ser Phe Val Asp Thr  Gly Gly Leu 
    1025                 1030                 1035             


Ala Met  Glu Gln Tyr Pro Ile  Ser Lys Leu Arg Val  Glu Tyr Glu 
    1040                 1045                 1050             


Leu Ala  Lys Tyr Gln Thr Ala  Arg Val Cys Ala Phe  Glu Gln Thr 
    1055                 1060                 1065             


Leu Glu  Leu Glu Glu Ser Leu  Leu Thr Arg Tyr Pro  His Leu Pro 
    1070                 1075                 1080             


Asp Lys  Asn Phe Arg Lys Met  Leu Glu Ser Trp Ser  Asp Pro Leu 
    1085                 1090                 1095             


Leu Asp  Lys Trp Pro Asp Leu  His Arg Lys Val Arg  Leu Leu Ile 
    1100                 1105                 1110             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1115                 1120                 1125             


Glu Ala  Val Phe Ser Ser Ile  Arg Lys Tyr Asp Pro  Ser Ser Pro 
    1130                 1135                 1140             


Asp Ala  Ile Glu Glu Arg Met  Gly Leu Asn Ile Ala  His Arg Leu 
    1145                 1150                 1155             


Ser Glu  Glu Val Lys Gln Ala  Lys Glu Thr Val Glu  Arg Ile Ile 
    1160                 1165                 1170             


Gln Val  
    1175 


<210>  1403
<211>  1135
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1403

Met Asn Thr Val Pro Ala Ser Glu Asn Lys Gly Gln Ser Arg Thr Val 
1               5                   10                  15      


Glu Asp Asp Pro Gln Tyr Phe Gly Leu Tyr Leu Asn Leu Ala Arg Glu 
            20                  25                  30          


Asn Leu Ile Glu Val Glu Ser His Val Arg Ile Lys Phe Gly Lys Lys 
        35                  40                  45              


Lys Leu Asn Glu Glu Ser Leu Lys Gln Ser Leu Leu Cys Asp His Leu 
    50                  55                  60                  


Leu Ser Val Asp Arg Trp Thr Lys Val Tyr Gly His Ser Arg Arg Tyr 
65                  70                  75                  80  


Leu Pro Phe Leu His Tyr Phe Asp Pro Asp Ser Gln Ile Glu Lys Asp 
                85                  90                  95      


His Asp Ser Lys Thr Gly Val Asp Pro Asp Ser Ala Gln Arg Leu Ile 
            100                 105                 110         


Arg Glu Leu Tyr Ser Leu Leu Asp Phe Leu Arg Asn Asp Phe Ser His 
        115                 120                 125             


Asn Arg Leu Asp Gly Thr Thr Phe Glu His Leu Glu Val Ser Pro Asp 
    130                 135                 140                 


Ile Ser Ser Phe Ile Thr Gly Thr Tyr Ser Leu Ala Cys Gly Arg Ala 
145                 150                 155                 160 


Gln Ser Arg Phe Ala Asp Phe Phe Lys Pro Asp Asp Phe Val Leu Ala 
                165                 170                 175     


Lys Asn Arg Lys Glu Gln Leu Ile Ser Val Ala Asp Gly Lys Glu Cys 
            180                 185                 190         


Leu Thr Val Ser Gly Leu Ala Phe Phe Ile Cys Leu Phe Leu Asp Arg 
        195                 200                 205             


Glu Gln Ala Ser Gly Met Leu Ser Arg Ile Arg Gly Phe Lys Arg Thr 
    210                 215                 220                 


Asp Glu Asn Trp Ala Arg Ala Val His Glu Thr Phe Cys Asp Leu Cys 
225                 230                 235                 240 


Ile Arg His Pro His Asp Arg Leu Glu Ser Ser Asn Thr Lys Glu Ala 
                245                 250                 255     


Leu Leu Leu Asp Met Leu Asn Glu Leu Asn Arg Cys Pro Arg Ile Leu 
            260                 265                 270         


Tyr Asp Met Leu Pro Glu Glu Glu Arg Ala Gln Phe Leu Pro Ala Leu 
        275                 280                 285             


Asp Glu Asn Ser Met Asn Asn Leu Ser Glu Asn Ser Leu Asn Glu Glu 
    290                 295                 300                 


Ser Arg Leu Leu Trp Asp Gly Ser Ser Asp Trp Ala Glu Ala Leu Thr 
305                 310                 315                 320 


Lys Arg Ile Arg His Gln Asp Arg Phe Pro Tyr Leu Met Leu Arg Phe 
                325                 330                 335     


Ile Glu Glu Met Asp Leu Leu Lys Gly Ile Arg Phe Arg Val Asp Leu 
            340                 345                 350         


Gly Glu Ile Glu Leu Asp Ser Tyr Ser Lys Lys Val Gly Arg Asn Gly 
        355                 360                 365             


Glu Tyr Asp Arg Thr Ile Thr Asp His Ala Leu Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Asp Phe Gln Asn Glu Glu Glu Val Ser Arg Met Ile Ser Gly Glu 
385                 390                 395                 400 


Ala Ser Tyr Pro Val Arg Phe Ser Leu Phe Ala Pro Arg Tyr Ala Ile 
                405                 410                 415     


Tyr Asp Asn Lys Ile Gly Tyr Cys His Thr Ser Asp Pro Val Tyr Pro 
            420                 425                 430         


Lys Ser Lys Thr Gly Glu Lys Arg Ala Leu Ser Asn Pro Gln Ser Met 
        435                 440                 445             


Gly Phe Ile Ser Val His Asp Leu Arg Lys Leu Leu Leu Met Glu Leu 
    450                 455                 460                 


Leu Cys Glu Gly Ser Phe Ser Arg Met Gln Ser Gly Phe Leu Arg Lys 
465                 470                 475                 480 


Ala Asn Arg Ile Leu Asp Glu Thr Ala Glu Gly Lys Leu Gln Phe Ser 
                485                 490                 495     


Ala Leu Phe Pro Glu Met Arg His Arg Phe Ile Pro Pro Gln Asn Pro 
            500                 505                 510         


Lys Ser Lys Asp Arg Arg Glu Lys Ala Glu Thr Thr Leu Glu Lys Tyr 
        515                 520                 525             


Lys Gln Glu Ile Lys Gly Arg Lys Asp Lys Leu Asn Ser Gln Leu Leu 
    530                 535                 540                 


Ser Ala Phe Asp Met Asn Gln Arg Gln Leu Pro Ser Arg Leu Leu Asp 
545                 550                 555                 560 


Glu Trp Met Asn Ile Arg Pro Ala Ser His Ser Val Lys Leu Arg Thr 
                565                 570                 575     


Tyr Val Lys Gln Leu Asn Glu Asp Cys Arg Leu Arg Leu Arg Lys Phe 
            580                 585                 590         


Arg Lys Asp Gly Asp Gly Lys Ala Arg Ala Ile Pro Leu Val Gly Glu 
        595                 600                 605             


Met Ala Thr Phe Leu Ser Gln Asp Ile Val Arg Met Ile Ile Ser Glu 
    610                 615                 620                 


Glu Thr Lys Lys Leu Ile Thr Ser Ala Tyr Tyr Asn Glu Met Gln Arg 
625                 630                 635                 640 


Ser Leu Ala Gln Tyr Ala Gly Glu Glu Asn Arg Arg Gln Phe Arg Ala 
                645                 650                 655     


Ile Val Ala Glu Leu His Leu Leu Asp Pro Ser Ser Gly His Pro Phe 
            660                 665                 670         


Leu Ser Ala Thr Met Glu Thr Ala His Arg Tyr Thr Glu Asp Phe Tyr 
        675                 680                 685             


Lys Cys Tyr Leu Glu Lys Lys Arg Glu Trp Leu Ala Lys Thr Phe Tyr 
    690                 695                 700                 


Arg Pro Glu Gln Asp Glu Asn Thr Lys Arg Arg Ile Ser Val Phe Phe 
705                 710                 715                 720 


Val Pro Asp Gly Glu Ala Arg Lys Leu Leu Pro Leu Leu Ile Arg Arg 
                725                 730                 735     


Arg Met Lys Glu Gln Asn Asp Leu Gln Asp Trp Ile Arg Asn Lys Gln 
            740                 745                 750         


Ala His Pro Ile Asp Leu Pro Ser His Leu Phe Asp Ser Lys Ile Met 
        755                 760                 765             


Glu Leu Leu Lys Val Lys Asp Gly Lys Lys Lys Trp Asn Glu Ala Phe 
    770                 775                 780                 


Lys Asp Trp Trp Ser Thr Lys Tyr Pro Asp Gly Met Gln Pro Phe Tyr 
785                 790                 795                 800 


Gly Leu Arg Arg Glu Leu Asn Ile His Gly Lys Ser Val Ser Tyr Ile 
                805                 810                 815     


Pro Ser Asp Gly Lys Lys Phe Ala Asp Cys Tyr Thr His Leu Met Glu 
            820                 825                 830         


Lys Thr Val Gln Asp Lys Lys Arg Glu Leu Arg Thr Ala Gly Lys Pro 
        835                 840                 845             


Val Pro Pro Asp Leu Ala Ala Asp Ile Lys Arg Ser Phe His Arg Ala 
    850                 855                 860                 


Val Asn Glu Arg Glu Phe Met Leu Arg Leu Val Gln Glu Asp Asp Arg 
865                 870                 875                 880 


Leu Met Leu Met Ala Ile Asn Lys Met Met Thr Asp Arg Glu Glu Asp 
                885                 890                 895     


Ile Leu Pro Gly Leu Lys Asn Ile Asp Ser Ile Leu Asp Glu Glu Asn 
            900                 905                 910         


Gln Phe Ser Leu Ala Val His Ala Lys Val Leu Glu Lys Glu Gly Glu 
        915                 920                 925             


Gly Gly Asp Asn Ser Leu Ser Leu Val Pro Ala Thr Ile Glu Ile Lys 
    930                 935                 940                 


Ser Lys Arg Lys Asp Trp Ser Lys Tyr Ile Arg Tyr Arg Tyr Asp Arg 
945                 950                 955                 960 


Arg Val Pro Gly Leu Met Ser His Phe Pro Glu His Lys Ala Thr Leu 
                965                 970                 975     


Asp Glu Val Lys Thr Leu Leu Gly Glu Tyr Asp Arg Cys Arg Ile Lys 
            980                 985                 990         


Ile Phe Asp Trp Ala Phe Ala Leu  Glu Gly Ala Ile Met  Ser Asp Arg 
        995                 1000                 1005             


Asp Leu  Lys Pro Tyr Leu His  Glu Ser Ser Ser Arg  Glu Gly Lys 
    1010                 1015                 1020             


Ser Gly  Glu His Ser Thr Leu  Val Lys Met Leu Val  Glu Lys Lys 
    1025                 1030                 1035             


Gly Cys  Leu Thr Pro Asp Glu  Ser Gln Tyr Leu Ile  Leu Ile Arg 
    1040                 1045                 1050             


Asn Lys  Ala Ala His Asn Gln  Phe Pro Cys Ala Ala  Glu Met Pro 
    1055                 1060                 1065             


Leu Ile  Tyr Arg Asp Val Ser  Ala Lys Val Gly Ser  Ile Glu Gly 
    1070                 1075                 1080             


Ser Ser  Ala Lys Asp Leu Pro  Glu Gly Ser Ser Leu  Val Asp Ser 
    1085                 1090                 1095             


Leu Trp  Lys Lys Tyr Glu Met  Ile Ile Arg Lys Ile  Leu Pro Ile 
    1100                 1105                 1110             


Leu Asp  Pro Glu Asn Arg Phe  Phe Gly Lys Leu Leu  Asn Asn Met 
    1115                 1120                 1125             


Ser Gln  Pro Ile Asn Asp Leu  
    1130                 1135 


<210>  1404
<211>  1119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1404

Met Thr Glu Gln Asn Glu Arg Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Phe Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Thr His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Tyr Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Gly Thr Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Thr Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Phe Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Asp Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Asp Glu Ile Asn Thr Arg Asp 
    530                 535                 540                 


Glu Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Gly Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Tyr Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Leu Ala Lys Leu Lys Lys Glu Ile Leu Glu Ala 
        835                 840                 845             


Lys Glu His Pro Tyr His Asp Phe Lys Ser Trp Gln Lys Phe Glu Arg 
    850                 855                 860                 


Glu Leu Arg Leu Val Lys Asn Gln Asp Ile Ile Thr Trp Met Ile Cys 
865                 870                 875                 880 


Arg Asp Leu Met Glu Glu Asn Lys Val Glu Gly Leu Asp Thr Gly Thr 
                885                 890                 895     


Leu Tyr Leu Lys Asp Ile Arg Thr Asp Val Gln Glu Gln Gly Ser Leu 
            900                 905                 910         


Asn Val Leu Asn His Val Lys Pro Met Arg Leu Pro Val Val Val Tyr 
        915                 920                 925             


Arg Ala Asp Ser Arg Gly His Val His Lys Glu Glu Ala Pro Leu Ala 
    930                 935                 940                 


Thr Val Tyr Ile Glu Glu Arg Asp Thr Lys Leu Leu Lys Gln Gly Asn 
945                 950                 955                 960 


Phe Lys Ser Phe Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe 
                965                 970                 975     


Val Asp Thr Gly Gly Leu Ala Met Glu Gln Tyr Pro Ile Ser Lys Leu 
            980                 985                 990         


Arg Val Glu Tyr Glu Leu Ala Lys  Tyr Gln Thr Ala Arg  Val Cys Ala 
        995                 1000                 1005             


Phe Glu  Gln Thr Leu Glu Leu  Glu Glu Ser Leu Leu  Thr Arg Tyr 
    1010                 1015                 1020             


Pro His  Leu Pro Asp Lys Asn  Phe Arg Lys Met Leu  Glu Ser Trp 
    1025                 1030                 1035             


Ser Asp  Pro Leu Leu Asp Lys  Trp Pro Asp Leu His  Arg Lys Val 
    1040                 1045                 1050             


Arg Leu  Leu Ile Ala Val Arg  Asn Ala Phe Ser His  Asn Gln Tyr 
    1055                 1060                 1065             


Pro Met  Tyr Asp Glu Ala Val  Phe Ser Pro Ile Arg  Lys Tyr Asp 
    1070                 1075                 1080             


Pro Ser  Ser Leu Asp Ala Ile  Glu Glu Arg Met Gly  Leu Asn Ile 
    1085                 1090                 1095             


Ala His  Arg Leu Ser Glu Glu  Val Lys Gln Ala Lys  Glu Met Val 
    1100                 1105                 1110             


Glu Arg  Ile Ile Gln Val 
    1115                 


<210>  1405
<211>  1128
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (610)..(624)
<223>  Xaa can be any naturally occurring amino acid

<400>  1405

Met Asp Ile Leu Asp Leu Ser Thr Asp Leu Gln Gln Ala Tyr Phe Ala 
1               5                   10                  15      


Thr Tyr Leu Asn Met Ala Gln Asn Asn Val Phe Ile Thr Met Lys Asp 
            20                  25                  30          


Ile Val Glu Arg Leu Cys Leu Lys Gln Thr Phe Phe Lys Asp Gly Lys 
        35                  40                  45              


Glu Ile Ile Gln Ala Phe Glu Arg Asp Asn Cys Lys Asp Ala Thr Ile 
    50                  55                  60                  


Leu Gln Asp Val Tyr Leu Val Thr Leu Ser Ala Asp Lys Gln Glu Gln 
65                  70                  75                  80  


Leu Lys Arg Lys Leu Leu Arg Ser Phe Pro Phe Leu Val Pro Met Ile 
                85                  90                  95      


Ser Thr Asp Arg Phe Tyr Ala Phe Phe Asn Lys His Glu Leu Tyr Tyr 
            100                 105                 110         


Ala Asn Glu Gln His Ala Glu Asp Thr Asn Thr Asp Val Thr Ile Arg 
        115                 120                 125             


Lys Glu Asp Glu Leu Leu Lys Asn Ser Ser Ile Leu Thr Ile Val His 
    130                 135                 140                 


Lys Leu Gln Thr Thr Leu Asn Val Leu Ser Phe Tyr Arg Asn Asn Ala 
145                 150                 155                 160 


Ser His Thr Met Ser Ile Asn Asp Asp Lys Ala Leu Glu Ile Ile Ser 
                165                 170                 175     


Asp Ser Asn Lys Thr Ala Ile Ala Leu Asp Cys Val Phe Lys Gln Ala 
            180                 185                 190         


Cys Gly Val Ile Lys Glu Arg Phe Ser Leu Lys Gly Asn Glu His Glu 
        195                 200                 205             


Gly Ala Asn Leu Gln Phe Ile His Asn Ala Arg Val Thr Pro Lys Tyr 
    210                 215                 220                 


Thr Gly Lys Lys Asp Gln Lys Ile Gln Val Pro Asn Phe Asp Tyr Ala 
225                 230                 235                 240 


His Cys Phe Tyr Tyr Lys Asn Asn Glu Glu Tyr Thr Met Ser Arg Met 
                245                 250                 255     


Ala Val Val Tyr Leu Ile Cys Met Phe Ile Glu Lys Ser Tyr Ala Thr 
            260                 265                 270         


Gln Phe Phe Ser Gln Ile Gly Arg Glu Phe Tyr Lys Gly Ile Tyr Lys 
        275                 280                 285             


Asn Glu Asn Tyr Lys Met Tyr Met Arg Glu Ile Tyr Ser Cys Tyr Arg 
    290                 295                 300                 


Ile Arg Met Pro Lys Asn Thr Thr Asn Pro Tyr Glu Asp Asn Val Met 
305                 310                 315                 320 


Leu Ala Met Asp Ile Leu Asn Glu Ile Thr Lys Cys Pro Asn Glu Leu 
                325                 330                 335     


Phe Asn Cys Leu Asn Arg Lys Asp Gln Gln Lys Phe Glu Lys Glu Thr 
            340                 345                 350         


Thr Glu Asn Ser Asp Phe Pro Glu Arg Val Leu Leu Arg Arg Ser Ala 
        355                 360                 365             


Asp Arg Phe Pro Glu Leu Ala Leu Lys Trp Ile Asp Ser Asn Lys Val 
    370                 375                 380                 


Phe Asn Lys Leu Arg Phe Asn Val Ile Tyr Gly Lys Tyr His Asp Ile 
385                 390                 395                 400 


Phe Lys Asp Glu Leu Gln Glu Thr Pro Gly Glu Lys Lys Cys Cys Asp 
                405                 410                 415     


Gly Ile Lys Arg Lys Arg Trp Leu Ser Lys Glu Leu Thr Ala Phe Gly 
            420                 425                 430         


Arg Ile Asp Glu Leu Glu Lys Gln Arg Thr Asp Lys Ala Leu Asn Trp 
        435                 440                 445             


Asp Gly Ile Asp Leu Val Lys Lys Phe Glu Ala Asp Pro Glu Ala Asp 
    450                 455                 460                 


Lys Pro Trp Ile Thr Asp Met Arg Cys Gln Tyr Val Ile Gly Asp Gly 
465                 470                 475                 480 


Ser Ile Gly Ile Lys Met Val Gln Gly Asn Thr Ile Leu Pro Ser Ile 
                485                 490                 495     


Lys Gly Lys Glu Leu Lys Glu Ile Lys Thr Pro Ser Pro Asp Phe Leu 
            500                 505                 510         


Leu Ser Val Tyr Glu Leu Pro Ala Leu Val Phe Leu Thr Ile Leu Lys 
        515                 520                 525             


Pro Asp Val Ala Glu Asn Leu Ile Val Gly Tyr Arg Glu Lys Tyr Val 
    530                 535                 540                 


Ser Phe Leu Asn Lys Leu Lys Asn Gly Glu Ile Gln Pro Val Asp Ser 
545                 550                 555                 560 


Glu Ala Ala Leu Lys Glu Ile Ile Glu Lys Gln Gly Phe Glu Trp Lys 
                565                 570                 575     


Asn Ile Pro Glu Lys Ile Lys Lys Tyr Leu Leu Lys Arg Arg Ala Asn 
            580                 585                 590         


Phe Thr Lys Tyr Ala Lys Lys Ile Leu Asp Asp Glu Ile Gln Ser Thr 
        595                 600                 605             


Lys Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    610                 615                 620                 


Val Asp Pro Lys Arg Phe Leu Pro Gly Lys Ile Ala Lys Trp Leu Thr 
625                 630                 635                 640 


Val Asp Ile Val Tyr Phe Cys Lys Tyr Glu Val Gly Ser Asp Lys Pro 
                645                 650                 655     


Thr Gly Met Asn Tyr Asn Val Met Gln Ser Lys Leu Ala Thr Phe Ala 
            660                 665                 670         


Lys Ser Asn Gln Phe Asp Asp Ile Leu Gln Met Phe Asn Ser Leu Asp 
        675                 680                 685             


Met Cys Lys Gly Gly Val Ala Glu His Pro Phe Leu Asp Lys Val Leu 
    690                 695                 700                 


Glu Leu Lys Pro Lys Asn Val Glu Gln Phe Phe Gly Met Tyr Leu Lys 
705                 710                 715                 720 


Glu Lys Lys Ala Tyr Leu Glu Glu Val Gln Ser Gln Asn Gln Tyr Lys 
                725                 730                 735     


Thr Leu His Phe Leu His Pro Asn Lys Arg Lys Trp Gln Glu Pro Asn 
            740                 745                 750         


Ile Val Asn Leu Val Asn Asp Tyr Leu Lys Leu Pro Leu Gln Leu Pro 
        755                 760                 765             


Lys Gly Leu Phe Asp Ala Val Ile Lys Ser Ile Ile Ser Lys Asp Cys 
    770                 775                 780                 


Pro Thr Leu Lys Glu Asn Asp Thr Thr Ser Tyr Met Ile Asn Ala Tyr 
785                 790                 795                 800 


Met His Ser Lys Asp Asp Asp Ile Gln Glu Phe Tyr Lys Phe Cys Arg 
                805                 810                 815     


Thr Tyr Pro Val Phe Glu Lys Leu Asp Lys Val Asn Asn Gly Glu Ile 
            820                 825                 830         


Lys Tyr Arg Thr Lys Asp Glu Leu His Phe Lys Thr Ala Asn Asn Ser 
        835                 840                 845             


Asp Gln Lys Phe Asp Ser Lys Asp Leu Phe Lys Gln Glu Leu Ala Lys 
    850                 855                 860                 


Tyr Ile Arg Ile Cys Lys Ala Asn Pro Lys Lys Tyr Arg Asp Phe Asp 
865                 870                 875                 880 


Ala Lys Thr Ala Thr Thr Lys Leu Asn His Leu Phe Asn Asn Tyr Asp 
                885                 890                 895     


Asn Thr Glu Lys Ala Ile Thr Arg Tyr Ser Val Gln Asp Phe Leu Leu 
            900                 905                 910         


Met Leu Ile Ala Glu Lys Leu Leu Leu Asn Gln Gln Ile Lys Lys Asp 
        915                 920                 925             


Lys Lys Arg Asn Asn Glu Lys Ile Glu Ile Ser Ile Asp Ser Phe Lys 
    930                 935                 940                 


Leu Lys Gly Ile Ala Pro Asp Ser Asp Lys Gly Leu Leu Ser Glu Thr 
945                 950                 955                 960 


Val Glu Ile Pro Ile Gln Leu Pro Lys Pro Asn Gly Tyr Thr Val Thr 
                965                 970                 975     


Trp Thr Thr Lys Ile Lys Asp Tyr Ser Arg Ile Tyr Lys Leu Tyr Asn 
            980                 985                 990         


Asp Arg Arg Phe Leu Ser Leu Leu  Gly Leu Leu Pro Lys  Gly Asn Tyr 
        995                 1000                 1005             


Pro Ala  Glu Asp Ile Met Arg  Glu Phe Glu Asn Tyr  Asp Arg Asn 
    1010                 1015                 1020             


Cys Ile  Glu Ala Phe Lys Arg  Ile Leu Asn Phe Glu  Arg Lys Ala 
    1025                 1030                 1035             


Leu Lys  Ile Thr Ser Val Lys  Ala Ala Asn Asp Gln  Tyr Val Ala 
    1040                 1045                 1050             


Glu Asn  Gly Arg Ser Asn Phe  Tyr Thr Ile Leu Asp  Ala Leu Leu 
    1055                 1060                 1065             


Asn His  Leu Gly Phe Cys Gly  Ala Glu Arg Asp Lys  Tyr Leu Met 
    1070                 1075                 1080             


Ile Asn  Tyr Phe Arg Asp Lys  Tyr Ala His Tyr Gln  Tyr Pro Glu 
    1085                 1090                 1095             


Glu Gly  Leu Thr Leu Thr Ser  Leu Lys Asp Ala Ser  Asn Lys Met 
    1100                 1105                 1110             


Phe Asp  Lys Leu Asn Asp Leu  Val Asp Glu Ile Asn  Asn Lys Ile 
    1115                 1120                 1125             


<210>  1406
<211>  1128
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1406

Met Glu Ile Leu Thr Ile Pro Glu Val Ile Lys Cys Arg Thr Leu Ser 
1               5                   10                  15      


Asp Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Val Leu Asn Ile Ser Asn His Ile Ala Lys Glu Phe Lys Leu Pro Leu 
        35                  40                  45              


Leu Pro Glu Glu Ala His Leu Lys Asn Ser Phe Leu Cys Lys Lys Glu 
    50                  55                  60                  


Asn Lys Lys Ile Asp Trp Asn His Val Tyr Ala Arg Thr Ile Arg Phe 
65                  70                  75                  80  


Leu Ser Val Met Lys Val Phe Asp Ala Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Lys Thr Ile Asp Trp Glu Gly Lys Asp Phe Ala Ser Met Cys Asp 
            100                 105                 110         


Thr Leu Asn Ile Val Phe Ser Glu Leu Gln Glu Phe Ser Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Glu Thr Lys Arg Lys Thr Thr Val 
    130                 135                 140                 


Ser Asp Glu Leu Ala Leu Phe Leu Arg Thr Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Glu Tyr Thr Lys Val Arg Phe Lys Gly Ile Leu Asn Asp Glu Asp Tyr 
                165                 170                 175     


Gln Leu Val Val Ser Lys Lys Met Leu Glu Thr Asn His Thr Ile Thr 
            180                 185                 190         


His Glu Gly Leu Val Phe Leu Thr Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Arg Phe Ile Arg Lys Ile His Gly Leu Ser Gly Pro Lys Asp 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Cys Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro Gln Glu Gln Phe Arg Ser Asp Asn Arg Arg Gln Ala Ile Ser 
                245                 250                 255     


Leu Glu Leu Met Asn Glu Leu Lys Lys Cys Pro Lys Val Leu Tyr His 
            260                 265                 270         


Val Ile Thr Glu Glu Trp Lys Gln Lys Leu Lys Ser Val Pro Glu Glu 
        275                 280                 285             


Leu Glu Thr Lys Asn Leu His Tyr Asn Thr Lys Arg Glu Thr Lys Ile 
    290                 295                 300                 


Glu Phe Glu Asp Tyr Asp Leu Tyr Ile Glu Ser Leu Thr Lys Gln Val 
305                 310                 315                 320 


Arg Tyr Asn Asn Arg Phe Ser Glu Phe Ala Leu Lys Tyr Ile Asp Glu 
                325                 330                 335     


Thr Gly Ile Phe Ser Glu Phe Arg Phe Gln Leu Asp Leu Gly Lys Ile 
            340                 345                 350         


Leu Val Asp Glu Tyr Leu Lys Asn Phe Asn Asp Glu Arg Val Gln Arg 
        355                 360                 365             


Cys Ile Ile Glu Asn Ala Lys Ala Phe Gly Lys Leu Asn Asp Tyr Thr 
    370                 375                 380                 


Asn Glu Thr Lys Val Met Ser Leu Ile Val Asn Gly Pro Pro Leu Lys 
385                 390                 395                 400 


Ser Phe Asp Arg Phe Ala Pro His Tyr Asn Ile Glu Ser Asn Lys Ile 
                405                 410                 415     


Gly Ile Ser Thr His Glu Val Thr Ala Lys Leu Val Pro Asn Ser Lys 
            420                 425                 430         


Gly Glu Pro Ala Lys Lys Leu His Gln Pro Leu Pro Glu Ala Phe Leu 
        435                 440                 445             


Ser Leu His Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu Gln Lys 
    450                 455                 460                 


Gly Glu Pro Glu Lys Leu Ile Asn Glu Phe Ile Leu Val Asn Asn Ser 
465                 470                 475                 480 


Lys Leu Met Asn Met Ser Phe Ile Glu Glu Val Lys Asn Gln Leu Pro 
                485                 490                 495     


Lys Glu Trp Asp Lys Phe Gln Arg Arg Thr Asn Ala Lys His Glu Leu 
            500                 505                 510         


Ala Tyr Asp Glu Asn Thr Leu Ala Phe Leu Leu Gln Arg Lys Gln Ile 
        515                 520                 525             


Leu Asn Lys Thr Leu Leu Ala Tyr Gln Leu Asn Asp Lys Gln Ile Pro 
    530                 535                 540                 


Thr Arg Ile Leu Asp Tyr Trp Leu Asn Ile Ser Asp Ala Asp Glu Glu 
545                 550                 555                 560 


Arg Ala Ile Ser Asn Arg Leu Lys Ser Ile Lys Arg Asp Cys Met Ser 
                565                 570                 575     


Arg Leu Lys Ala Leu Ser Lys Phe Asn Glu Asn Gly Asn Arg Asn Lys 
            580                 585                 590         


Ile Pro Gly Ile Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile Ile 
        595                 600                 605             


Glu Met Val Val Ser Glu Gly Lys Lys Arg Lys Ile Thr Ser Phe Tyr 
    610                 615                 620                 


Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Gly Asp Pro Asp Lys 
625                 630                 635                 640 


Lys Gln Leu Phe Ile His Ile Val Thr Lys Glu Leu Lys Leu Asn Asp 
                645                 650                 655     


Pro Gly Gly His Pro Phe Leu Asp Lys Leu Asp Leu Gln Lys Ile Asn 
            660                 665                 670         


Ser Thr Thr Gly Phe Tyr Glu Ile Tyr Leu Gln Glu Lys Gly His Lys 
        675                 680                 685             


Met Val Pro Glu Asn Asn Pro Lys Thr Gly Lys Val Ile Tyr Thr Asp 
    690                 695                 700                 


His Ser Trp Met Ala Leu Thr Phe Tyr Lys Ile Glu Phe Asn Asp Lys 
705                 710                 715                 720 


Val Asp Met Leu Met Thr Val Val Lys Leu Pro Leu Lys Lys Leu Asn 
                725                 730                 735     


Ile Pro Phe Thr Leu Arg Gln Leu Ser Gly Lys Thr Asn Asn Thr Leu 
            740                 745                 750         


Lys Gln Trp Leu Asn Asn Leu Thr Gln Gly Lys Lys Arg Asn Asp Gly 
        755                 760                 765             


Lys Arg Pro Ile Asn Leu Pro Thr Asn Leu Phe Asp Glu Arg Leu Ala 
    770                 775                 780                 


Glu Leu Leu Arg Lys Asp Leu Asp Asn Lys Lys Ile Val Tyr Trp Pro 
785                 790                 795                 800 


Tyr Ala Asn Trp Asn Glu Leu Phe Lys Thr Trp Trp Ser Ser Arg Asn 
                805                 810                 815     


Asp Gly Leu Gln Ser Phe Tyr Asn Ala Glu Arg Glu Tyr Arg Ile Phe 
            820                 825                 830         


Asp Glu Lys Val Asn Phe Tyr Pro Asn Arg Lys Glu Asn Phe Ala Asp 
        835                 840                 845             


Tyr Tyr Gln His Ala Leu Lys Leu Ala Phe Gln Lys Lys Gln Ser Lys 
    850                 855                 860                 


Arg Ile Leu Glu Gln Met Tyr Asp Gln His Leu Pro Asp Ile Leu Phe 
865                 870                 875                 880 


Asp Gln Val Glu Lys Thr Phe Arg His Thr Ile Ala Glu Thr Glu Lys 
                885                 890                 895     


Glu Ile Arg Ile Leu Gln Glu Glu Asp His Ile Met Leu Leu Met Leu 
            900                 905                 910         


Glu Ser Leu Leu Asp Asp Gly Ser Lys Gln Gln Leu Lys Leu Ser Glu 
        915                 920                 925             


Ile Arg Thr His Leu Asn Arg Thr Thr Asn Ile Arg Gln Val Val Lys 
    930                 935                 940                 


Gly Lys Leu Ser Phe Asp Asp Ser Gly Glu Leu Ile Lys Asp Asn Thr 
945                 950                 955                 960 


Asn Ser Glu Ile Val Arg Thr Val Ser Val Thr Asp Gln Arg Lys Lys 
                965                 970                 975     


Leu His Gln Leu Pro Lys Leu Ile Phe Asp Ser Arg Leu Pro Glu Leu 
            980                 985                 990         


Leu Glu Tyr Phe Pro Asp Glu Glu  Ile Gln Met Glu Ser  Leu Lys Lys 
        995                 1000                 1005             


Glu Phe  Asp Thr Tyr Asn Thr  Thr Arg Gln Val Val  Leu Asn Leu 
    1010                 1015                 1020             


Ser Phe  Asn Leu Glu Lys Met  Ile Ile Glu Lys Gly  Arg Leu Asp 
    1025                 1030                 1035             


Arg Ile  Asn Glu Leu Leu Ser  Ser Ala Thr Gly Asp  Leu Leu Thr 
    1040                 1045                 1050             


Gly His  Ile Gly His Lys Thr  Tyr Leu Thr Trp Leu  Lys Asn His 
    1055                 1060                 1065             


Gly Ile  Ile Asp Asn Asp Thr  Phe Ile Phe Met Asn  Met Val Gln 
    1070                 1075                 1080             


Tyr Cys  Phe Ser His Asn Gln  Tyr Pro Gln Lys Lys  Thr Met Ala 
    1085                 1090                 1095             


Arg Leu  Ile Ser Arg Trp Asp  Gln His Arg Phe Ala  Leu Gln Ile 
    1100                 1105                 1110             


Glu Ala  Thr Tyr Ile Gln Lys  Ile Ala Gly Ile Ile  Glu Asp Leu 
    1115                 1120                 1125             


<210>  1407
<211>  1140
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1407

Met Glu Asn Asp Gln Gln Ile Leu Glu Asn Arg Arg Arg Thr Leu Ala 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Ser Asn His Leu Ala Thr Ser Phe Glu Gln Lys Ala 
        35                  40                  45              


Leu His Glu Glu Gly Gln Ile Pro Ala Ser Phe Leu Cys Asn Lys Ser 
    50                  55                  60                  


Ile Lys Lys Ile Asn Trp Asn His Val Tyr Ser Lys Ala Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Ile Phe Asp Ala Asp Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Arg Glu Thr Ser Asp Lys Glu Gly Lys Asp Phe Thr Ala Met Asn Glu 
            100                 105                 110         


Thr Leu Lys Leu Val Phe Asp Glu Leu Gln Ala Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Ala Asp Ser Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Val Glu Leu Ala Asp Phe Leu Thr Val Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Ala Asp Asp Asp Tyr 
                165                 170                 175     


Ala Val Val Glu Ser Lys Gln Ile Val Thr Pro Asp Asn Gln Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Ile Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Val Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Leu Ala Tyr Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asp Leu Arg Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Glu 
            260                 265                 270         


Val Ile Thr Glu Glu Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Glu Glu Glu Arg 
    290                 295                 300                 


Glu Lys Ile Leu Asp Glu Ile Asp Tyr Glu Asp Tyr Ile Glu Ser Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg His Ser Asn Arg Phe Pro Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Glu Lys Tyr Asn Lys Gln Phe Asp Gly Glu 
        355                 360                 365             


Ala Thr Glu Arg Lys Val Val Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asn Gln Glu Thr Val Glu Leu Lys Ile Asp Ser Ala 
385                 390                 395                 400 


Gln Arg Thr Asn Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Glu Ala Arg Leu Leu 
            420                 425                 430         


Thr Lys Ala Lys Pro Glu Ser Lys Val Ser Tyr Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Lys Ala Glu Glu Met Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Lys Val Asn Asp Ser Gln Leu Met Asn Met Gln Phe Ile Asp Glu 
                485                 490                 495     


Ile Lys Glu Gln Leu Pro Ala Asp Trp Asn Glu Phe Gly Lys Arg Ser 
            500                 505                 510         


Asp Ser Lys Lys Lys Lys Ala Tyr Thr Asn Ala Ala Arg Gln Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Lys Val Leu Ala Asn Tyr Gln Leu 
    530                 535                 540                 


Asn Asp Lys Gln Val Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Val 
545                 550                 555                 560 


Lys Glu Val Asp Asp Ser Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Met Glu Lys His Lys Val 
            580                 585                 590         


Asp Lys Ser Ala Arg Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Thr Asp Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Tyr 
625                 630                 635                 640 


Ala Asp Asn Glu Lys Lys Ala Thr Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Lys Asp Gly His Pro Phe Leu Ala Asn Ile Asn 
            660                 665                 670         


Leu Arg Gln Ile Arg Lys Thr Ser Gln Leu Tyr Glu Leu Tyr Leu Val 
        675                 680                 685             


Glu Lys Ala Asn Lys Gln Val Lys Lys Met Asn Pro Lys Thr Gln Arg 
    690                 695                 700                 


Thr Asn Asn Val Asp Glu Ser Trp Met Met Lys Ser Phe Tyr Ala Lys 
705                 710                 715                 720 


Glu Trp Asn Glu Glu Met Gly Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Thr Asn Ile Pro Phe Thr Ile Arg Gln Trp Glu Glu Lys 
            740                 745                 750         


Glu Lys His Asn Leu Gln Ala Trp Leu His Asn Ile Thr Lys Gly Lys 
        755                 760                 765             


Thr Ser Lys Asp Gly Lys Lys Ala Val Asp Leu Pro Thr Asn Leu Phe 
    770                 775                 780                 


Asp Asp Thr Leu Cys Glu Leu Leu Arg Glu Ala Leu Ile Asn Glu Gly 
785                 790                 795                 800 


Ile Asp Ala Thr Pro Thr Thr Lys Tyr Asn Glu Leu Leu Lys His Trp 
                805                 810                 815     


Trp Thr Ala Arg Glu Asp Ser Thr Gln Asp Phe Tyr Leu Ser Glu Arg 
            820                 825                 830         


Gln Tyr Asp Ile Tyr Asp Glu Lys Val Cys Phe Thr Ile Asn Ser Ser 
        835                 840                 845             


Ala His Phe Ala Asp Tyr Tyr Ala Pro Ala Leu Ser Lys Ala Tyr Ser 
    850                 855                 860                 


Arg Leu Arg Ala Glu Arg Asp Val Ala Arg Arg Thr Asp Lys Arg Leu 
865                 870                 875                 880 


Pro Pro Val Glu Arg Lys Asp Val Glu Arg Val Phe Lys Asn Thr Ile 
                885                 890                 895     


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
            900                 905                 910         


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asn Gln Gln Gln Leu Lys 
        915                 920                 925             


Leu Ser Lys Met Asp Ser Leu Leu Asn Glu Thr Lys Arg Ile Glu Gln 
    930                 935                 940                 


Val Ile Asn Thr Gln Leu Ser Phe Asp Gln Lys Gly Lys Glu Ile Lys 
945                 950                 955                 960 


Asp Lys Thr Asn Leu Glu Ile Val Lys Thr Ile Val Ala Glu Arg Lys 
                965                 970                 975     


Gln Lys Asn Tyr Thr Glu Met Arg Lys Tyr Val His Asp Arg Arg Leu 
            980                 985                 990         


Pro Glu Leu Phe Glu Tyr Ile Asp  Gly Asn Glu Leu Pro  Leu Asp Met 
        995                 1000                 1005             


Leu Leu  Asn Glu Leu Arg Ala  Tyr Asn Thr Ala Lys  Gln Val Val 
    1010                 1015                 1020             


Phe Asp  Thr Val Phe Ala Leu  Glu Lys Lys Ile Ile  Glu Thr Asp 
    1025                 1030                 1035             


Pro Glu  Gly Leu Lys Gln Leu  Asn Val Ser Lys Asp  Gly Gln Ile 
    1040                 1045                 1050             


Gln Thr  Gly Asn Ile Gln His  Lys Pro Tyr Val Gln  Trp Leu Glu 
    1055                 1060                 1065             


Asn Lys  Gly Leu Ile Thr Asp  Lys Asp Lys Gln Phe  Ile Asn Met 
    1070                 1075                 1080             


Val Arg  Asn Ser Phe Ser His  Asn Gln Phe Pro Gln  Arg Ser Thr 
    1085                 1090                 1095             


Val Glu  Leu Leu Met Pro Val  Trp Gln Asn Thr Asn  Ile Ala Leu 
    1100                 1105                 1110             


Gln Ile  Ala Arg Glu Tyr Gln  Gln Leu Ile Val Asp  Ile Ile Glu 
    1115                 1120                 1125             


Lys Ser  Leu His Pro His Lys  Gln His Gln Met Val  
    1130                 1135                 1140 


<210>  1408
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1408

Met Glu Thr Lys Gln Gln Val Gly Lys Gly Ile Ser Tyr Asp His Arg 
1               5                   10                  15      


Arg Pro Asp Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asp Gly Val Ile Gln Glu Phe Ala Met Arg Leu Asn Arg 
        35                  40                  45              


Glu Tyr Asp Pro Glu Asn Lys Asn Gln Ser Leu Phe Ser Tyr Phe Asn 
    50                  55                  60                  


Ile Asn Ala Ser Phe Thr Asp Trp Glu Arg Gly Val Asn Ile Leu Lys 
65                  70                  75                  80  


Glu Tyr Trp Pro Met Met Glu Phe Ile Asp Arg Pro Ala Thr Asp Lys 
                85                  90                  95      


Gln Phe Glu Ala Glu Lys Pro Glu Asn Arg Glu Ala Ala Lys Arg Lys 
            100                 105                 110         


Tyr Phe Leu Ala Thr Leu Gly Ala Leu Leu Thr Ser Ile Lys Asp Leu 
        115                 120                 125             


Arg His Tyr Tyr Thr His Tyr Tyr His Pro Pro Val His Leu Asn Asp 
    130                 135                 140                 


Asp Leu Phe Leu Phe Leu Asp His Ala Leu Leu Tyr Thr Ala Phe Asp 
145                 150                 155                 160 


Val Lys Lys Thr Lys Met Lys Asp Asp Lys Thr Arg Gln Leu Leu Asn 
                165                 170                 175     


Gln Asn Leu Ser Leu Glu Leu Glu Lys Leu Lys Lys Leu Lys Val Glu 
            180                 185                 190         


Glu Leu Lys Lys Lys Lys Glu Lys Gly Ile Lys Val Asn Leu Gln Asp 
        195                 200                 205             


Glu Lys Gly Ile Leu Asn Ala Ile Tyr Asn Asp Ala Phe Ala His Ile 
    210                 215                 220                 


Ile Thr Lys Glu Lys Asp Ser Asp Lys Asp Lys Leu Glu Thr Arg Tyr 
225                 230                 235                 240 


Lys Ser Ile Leu Pro Gln Asp Glu Ala Ala Glu Thr Gly Ile Asn Ile 
                245                 250                 255     


Ser Ile Ser Gly Leu Ile Phe Leu Leu Ser Leu Phe Leu Ser Arg Lys 
            260                 265                 270         


Glu Ile Glu Gln Leu Lys Ser Asn Ile Glu Gly Tyr Lys Gly Lys Val 
        275                 280                 285             


Leu Asn Ile Glu Thr Glu Val Asp Arg Lys His Asn Ser Leu Lys Tyr 
    290                 295                 300                 


Met Ala Thr His Trp Val Phe Ser Ile Leu Ala Phe Lys Gly Leu Lys 
305                 310                 315                 320 


Gln Arg Leu Thr Asn Ser Phe Glu Lys Glu Ser Leu Leu Ile Gln Met 
                325                 330                 335     


Met Asp Glu Leu Asn Lys Val Pro Asp Glu Leu Tyr Gln Thr Leu Ser 
            340                 345                 350         


Glu Thr Ala Lys Lys Glu Phe Leu Glu Asp Ile Asn Glu Tyr Val Ser 
        355                 360                 365             


Glu Gly Asp Asp Asn Glu Lys Ala Thr Tyr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Ser Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gln Phe Pro Thr Leu Lys Phe Gln Ile Phe Val Gly 
                405                 410                 415     


Gln Tyr Leu His Asp Asn Arg Pro Lys Thr Leu Ala Ser Asn Gly Met 
            420                 425                 430         


Thr Ala Gln Arg Met Ile Lys Glu Lys Ile Asn Leu Phe Gly Asn Leu 
        435                 440                 445             


Ser Glu Val Thr Lys His Lys Ser Asp Phe Phe Glu Lys Glu Ser Ala 
    450                 455                 460                 


Ala Gln Gly Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Trp Ala Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Val Tyr Ile Asp Met Ile Gly Lys Glu Gly Lys Ala 
                485                 490                 495     


Lys Glu Ile Gln Val Gln Ile Asn Lys Tyr Arg Lys Gln Leu Asn Pro 
            500                 505                 510         


Ala Pro Gln Arg Asp Lys Arg Ile Ser Lys Lys Glu Ile Ile Glu Gln 
        515                 520                 525             


Leu Tyr Lys Glu Lys Val Val Tyr Gly Asp Pro Thr Leu Met Leu Ser 
    530                 535                 540                 


Ala Asn Glu Leu Met Ala Leu Leu Tyr Glu Leu Ile Val Asn Gly Lys 
545                 550                 555                 560 


Ser Gly Ala Glu Leu Glu Asn Lys Ile Val Glu Gln Ile Ile Ala Arg 
                565                 570                 575     


Tyr Glu Gln Ile Glu Ala Tyr Asp Pro Thr Thr Gln Gln Leu Pro Thr 
            580                 585                 590         


Asn Gln Met Pro His Lys Leu Gln Lys Ser Arg Lys Asp Ser Lys Val 
        595                 600                 605             


Thr Asp Thr Asp Lys Leu Leu Lys Thr Ile Asp Lys Glu Ile Asp Glu 
    610                 615                 620                 


Gly Asn Lys Lys Leu Glu Leu Ile Ala Cys His Arg Lys Glu Trp Glu 
625                 630                 635                 640 


Glu Ala Glu Gln Arg Lys Lys Ser Gly Lys Arg Asn Asn Pro Gly Thr 
                645                 650                 655     


Lys Ser Arg Lys His Leu Phe Tyr Ala Ser Glu Met Gly Glu Glu Ala 
            660                 665                 670         


Thr Trp Ile Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Pro Ala Arg 
        675                 680                 685             


Ala Glu Trp Lys Gly Thr His His Ser Glu Leu Gln Arg Leu Leu Ala 
    690                 695                 700                 


Phe Tyr Ser Thr Gln Arg Leu Glu Ala Trp Gln Leu Val Glu Ser Val 
705                 710                 715                 720 


Trp Thr Ala Asn Thr His Ser Phe Trp Glu Glu Asn Phe Lys Glu Ala 
                725                 730                 735     


Phe Tyr Lys Pro Glu Phe Glu Asn Phe Tyr Gly Ala Tyr Ile Glu Ile 
            740                 745                 750         


Arg Thr Lys Ile Leu Thr Thr Cys Arg Ser Ile Leu Glu Asn Asn Pro 
        755                 760                 765             


Glu Ala Thr Met Asn Asn Asp Thr Glu Lys Glu Trp Asp Lys Val Phe 
    770                 775                 780                 


Thr Leu Phe Asp Lys Arg Leu Tyr Arg Thr Ser Thr Thr Asp Glu Gln 
785                 790                 795                 800 


Lys Lys Gln Leu Leu Thr Lys Pro Phe Ala Phe Pro Arg Gly Leu Phe 
                805                 810                 815     


Asp Asp Lys Pro Thr Phe Leu Pro Gly Ser Lys Pro Asn Glu Asn Pro 
            820                 825                 830         


Glu Arg Phe Ala Ala Trp Tyr Ser Tyr Gly Tyr Thr Tyr Ser Gly Lys 
        835                 840                 845             


Phe Gln Ser Phe Tyr Asp Met Pro Arg Asn Tyr Ser Asp Trp Tyr Lys 
    850                 855                 860                 


Lys Leu Lys Glu Asp Gly Lys Leu Pro Arg Leu Asp Lys Lys Thr Glu 
865                 870                 875                 880 


Gln Glu Lys Ile Leu Arg Phe Arg Met Asp Cys Asp Leu Asn Ile Lys 
                885                 890                 895     


His Ile Arg Phe Gln Asp Ile Tyr Val Lys Leu Met Val Asp Ser Leu 
            900                 905                 910         


Tyr Lys Ala Val Phe Gly Gln Gln Pro Glu Phe Asp Leu Ser His Leu 
        915                 920                 925             


Tyr Asp Thr Arg Ser Glu Arg Tyr Glu Asn Asn Thr Ile Ala Gln Arg 
    930                 935                 940                 


Gln Lys Ser Arg Gln Glu Gly Asp Asn Ser Asp Asn Ala Ile Asn Glu 
945                 950                 955                 960 


Asn Tyr Val Trp Asn Lys Thr Phe Ala Ile Ser Leu Tyr Asn Gly Arg 
                965                 970                 975     


Ile Thr Glu Ser Gln Val Lys Leu Lys Asp Val Gly Lys Phe Arg Arg 
            980                 985                 990         


Phe Ala Thr Asp Pro Arg Val Gln  Thr Leu Ile Ser Tyr  Asp Asp Thr 
        995                 1000                 1005             


Arg Thr  Trp Thr Lys Leu Glu  Ile Glu Asn Glu Leu  Asp Asn Lys 
    1010                 1015                 1020             


Ala Asp  Ala Tyr Glu Pro Ile  Arg Arg Thr Gln Ser  Leu Lys Ala 
    1025                 1030                 1035             


Ile Gln  Gln Leu Glu Lys Asn  Ile Leu Lys Lys Asn  Gly Phe Asn 
    1040                 1045                 1050             


Gly Lys  Gln His Pro Glu Glu  Leu Lys His Asn Gly  Asn Pro Asn 
    1055                 1060                 1065             


Phe Arg  Lys Tyr Ile Ala Asn  Gly Leu Leu Lys His  Arg Thr Asp 
    1070                 1075                 1080             


Ile Arg  Gln Glu Glu Leu Ala  Leu Ile Ser Asp Thr  Glu Phe Gln 
    1085                 1090                 1095             


Glu Ile  Gly Leu Glu Arg Ile  Arg Gln Thr Asn Pro  Leu Ile Gln 
    1100                 1105                 1110             


Lys Ala  Tyr Leu Leu Ile Leu  Leu Arg Asn Lys Phe  Gly His Asn 
    1115                 1120                 1125             


Gln Leu  Pro Asp Gln Glu His  Phe Arg Leu Met Arg  Ser Ile Tyr 
    1130                 1135                 1140             


Pro Tyr  Asn Gln Gln Glu Ser  Tyr Ser Ala Tyr Phe  Asn His Val 
    1145                 1150                 1155             


Ile Thr  Gln Ile Ile Glu Glu  Leu Asn Thr 
    1160                 1165             


<210>  1409
<211>  1126
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1409

Met Glu Thr Leu Leu Thr Pro Thr Glu Asn Lys Tyr Arg Thr Ile Asn 
1               5                   10                  15      


Asp Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Ser Met Ala Arg Leu Asn 
            20                  25                  30          


Val Phe Asn Ile Ser Asn His Ile Ala Lys Glu Phe Gly Gln Ser Leu 
        35                  40                  45              


Leu Glu Glu Glu Gly His Ile Lys Asn Ser Phe Leu Cys Asp Lys Asn 
    50                  55                  60                  


Asn Lys Lys Val Asn Trp Asn His Val His Ala Lys Ala Arg Arg Phe 
65                  70                  75                  80  


Leu Ser Ile Leu Lys Val Phe Asp Ala Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Leu Lys Ile Ile Glu Trp Glu Gly Lys Asp Phe Ser Leu Met Gly Asp 
            100                 105                 110         


Thr Leu Lys Ile Val Phe Arg Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Phe Tyr Ser Thr Glu Lys Gly Thr Ser Arg Lys Ile Lys Val 
    130                 135                 140                 


Ser Glu Glu Leu Ala Glu Phe Leu Lys Thr Asn Phe Arg Arg Ala Ile 
145                 150                 155                 160 


Glu Tyr Thr Lys Glu Arg Phe Lys Gly Gly Leu Ile Glu Glu Asp Phe 
                165                 170                 175     


Asn Leu Val Ala Ser Arg Lys Val Val Arg Asp Asp Leu Ala Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ala Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Thr Gly Leu Lys Gly Thr Gln Asn 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro His Asp Arg Phe Gln Ser Asp Asn Thr Arg Gln Ala Phe Ser 
                245                 250                 255     


Leu Asp Leu Ile Asn Glu Leu Asn Arg Cys Pro Lys Val Leu Tyr Asn 
            260                 265                 270         


Val Ile Thr Glu Glu Gly Lys Gln Leu Phe Arg Pro Gln Leu Glu Asp 
        275                 280                 285             


Leu Glu Ile Lys Asn Leu Ile Lys Asn Ser Thr Asn Asn Glu Glu Glu 
    290                 295                 300                 


Ile Asp Asn Tyr Asp Glu Tyr Ile Glu Ala Leu Thr Lys Arg Ile Arg 
305                 310                 315                 320 


His Thr Asn Arg Phe Ser Asp Phe Ala Leu Gln Phe Ile Asp Glu Thr 
                325                 330                 335     


Asp Val Phe Lys Lys Phe Arg Phe Gln Ile Asp Leu Gly Lys Leu Leu 
            340                 345                 350         


Val Asp Glu Tyr Asp Lys Ser Phe Asn Gly Glu Glu Val Glu Arg Lys 
        355                 360                 365             


Ile Ile Val Asn Ala Lys Ala Phe Arg Lys Leu Asn Ser Tyr Gly Thr 
    370                 375                 380                 


Glu Asp Glu Thr Leu Lys Leu Ile Glu Asn Gly Gln Gly Ser Lys Arg 
385                 390                 395                 400 


Phe Glu Gln Phe Ala Pro His Tyr Asn Thr Glu Asn Asn Lys Ile Gly 
                405                 410                 415     


Leu Ser Gly Lys Glu Leu Ile Ala Lys Leu Arg Pro Asn Ser Lys Gly 
            420                 425                 430         


Glu Ala Gly Lys Lys Leu His Gln Pro Leu Pro Glu Ala Phe Leu Ser 
        435                 440                 445             


Leu Lys Glu Leu Pro Lys Ile Ile Leu Leu Asn Tyr Leu Leu Pro Asp 
    450                 455                 460                 


Glu Pro Glu Lys Leu Ile Asn Asp Phe Ile Leu Val Asn Asn Ser Lys 
465                 470                 475                 480 


Leu Met Asn Met Ser Phe Ile Lys Glu Val Lys Ser Leu Leu Pro Lys 
                485                 490                 495     


Glu Trp Asn Glu Phe Lys Lys Arg Ser Asp Thr Lys Lys Gln Arg Ala 
            500                 505                 510         


Tyr Asn Glu Lys Ala Leu Ala Tyr Leu Leu His Arg Lys Gln Ile Leu 
        515                 520                 525             


Asn Gln Val Leu Ala Ala Tyr Gln Leu Asn Asp Lys Gln Ile Pro Arg 
    530                 535                 540                 


Arg Ile Leu Asp Tyr Trp Leu Asn Ile Val Asp Val Val Glu Gly Arg 
545                 550                 555                 560 


Ser Val Ser Asp Arg Ile Lys Met Met Lys Arg Asp Cys Met Ser Arg 
                565                 570                 575     


Leu Lys Ala Met Ala Lys Phe Lys Glu Asp Arg Asn Arg Asn Lys Ile 
            580                 585                 590         


Pro Lys Ile Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile Val Asp 
        595                 600                 605             


Met Val Val Gly Glu Glu Lys Lys Gln Lys Ile Thr Ser Phe Tyr Tyr 
    610                 615                 620                 


Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Pro Glu Lys Lys 
625                 630                 635                 640 


Gln Leu Phe Ile His Thr Val Ile Asn Glu Leu Lys Leu Asn Glu Gln 
                645                 650                 655     


Gly Gly His Pro Phe Leu His Lys Leu Asn Leu Gln Gln Ile Lys Asn 
            660                 665                 670         


Thr Ser Gly Phe Tyr Glu Ile Tyr Leu Gln Glu Lys Gly Gln Lys Met 
        675                 680                 685             


Val Ser Glu Lys Asn Phe Arg Thr Gly Arg Thr Ile Glu Thr Asp Lys 
    690                 695                 700                 


Ser Trp Met Ala Leu Thr Phe Tyr Lys Lys Glu Trp Asp Glu Lys Val 
705                 710                 715                 720 


Gly Lys Gln Leu Thr Val Val Arg Leu Pro Glu Asn Lys Ser Asn Ile 
                725                 730                 735     


Pro Phe Ser Leu Arg Leu Leu Glu Glu Lys Thr Val Tyr Thr Leu Glu 
            740                 745                 750         


Gln Trp Leu His Asn Val Thr Lys Gly Lys Lys Gln Asn Asp Thr Arg 
        755                 760                 765             


Gln Pro Val Asn Leu Pro Thr Asn Leu Phe Asp Glu Arg Leu Thr Val 
    770                 775                 780                 


Leu Leu Arg Gly Glu Leu Asp Lys Lys Gln Ile Ser Tyr Ala Pro Asn 
785                 790                 795                 800 


Ala Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Lys Ser Arg Asn Asp 
                805                 810                 815     


Ser Val Gln Ser Phe Tyr Lys Ala Glu Arg Glu Tyr Glu Ile Phe Gly 
            820                 825                 830         


Glu Lys Val Asn Phe Met Pro Asp Ser Lys Glu Arg Phe Ala Asp Tyr 
        835                 840                 845             


Tyr Gln His Ala Leu Thr Ala Ala Trp Gln Lys Lys Arg Lys Glu Arg 
    850                 855                 860                 


Ile Gln Gln Gln Lys Gln Asp Arg Arg Leu Pro Asp Ile Ser Phe Asp 
865                 870                 875                 880 


Gln Val Glu Lys Thr Phe Lys Gln Thr Ile Ala Glu Thr Glu Lys Glu 
                885                 890                 895     


Ile Arg Ile Val Gln Glu Glu Asp Arg Met Met Leu Leu Met Leu Glu 
            900                 905                 910         


Thr Leu Met Glu Asn Gly Lys Asp Leu Lys Leu Lys Leu Ser Gly Ile 
        915                 920                 925             


Asp Thr Leu Leu Asn Ala Thr Thr Glu Val Lys Gln Leu Val Ser Gly 
    930                 935                 940                 


Lys Leu Ser Phe Asn Gly Ser Gly Glu Leu Ile Lys Gly Lys Thr Asn 
945                 950                 955                 960 


Pro Glu Ile Ser Lys Thr Ile Thr Val Ala Arg Lys Arg Lys Asp Tyr 
                965                 970                 975     


Ser Met Leu Arg Lys Phe Val Phe Asp Arg Arg Leu Pro Glu Leu Phe 
            980                 985                 990         


Glu Tyr Phe Ala Glu Glu Glu Ile  Pro Ile Glu Val Leu  Lys Asp Glu 
        995                 1000                 1005             


Leu Asp  Ala Tyr Asn Lys Ala  Lys His Glu Val Phe  Asp Thr Val 
    1010                 1015                 1020             


Phe Glu  Leu Glu Glu Lys Ile  Ile Thr Leu Asp Ala  Asp Gly Ile 
    1025                 1030                 1035             


Arg Gln  Leu Phe Ile Asp Asp  Ala Gly Gln Pro Val  Thr Gly Asn 
    1040                 1045                 1050             


Ile Gln  His Lys Pro Tyr Val  Ile Trp Leu Lys Asn  Asn Gly Thr 
    1055                 1060                 1065             


Ile Asp  Asp Asn Thr Leu Thr  Phe Leu Asn Met Val  Arg Asn Cys 
    1070                 1075                 1080             


Phe Ser  His Asn Gln Tyr Pro  Gln Lys Lys Thr Met  Glu Leu Leu 
    1085                 1090                 1095             


Ile Gly  Gln Trp Glu Pro Asn  Arg Phe Ala Leu Thr  Ile Ala Gln 
    1100                 1105                 1110             


Thr Tyr  Lys Arg Lys Ile Asn  Ser Ile Met Lys His  Leu 
    1115                 1120                 1125     


<210>  1410
<211>  1135
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1410

Met Asn Thr Val Pro Ala Ser Glu Asn Lys Gly Gln Ser Arg Thr Val 
1               5                   10                  15      


Glu Asp Asp Pro Gln Tyr Phe Gly Leu Tyr Leu Asn Leu Ala Arg Glu 
            20                  25                  30          


Asn Leu Ile Glu Val Glu Ser His Val Arg Ile Lys Phe Gly Lys Lys 
        35                  40                  45              


Lys Leu Asn Glu Glu Ser Leu Lys Gln Ser Leu Leu Cys Asp His Leu 
    50                  55                  60                  


Leu Ser Val Asp Arg Trp Thr Lys Val Tyr Gly His Ser Arg Arg Tyr 
65                  70                  75                  80  


Leu Pro Phe Leu His Tyr Phe Asp Pro Asp Ser Gln Ile Glu Lys Asp 
                85                  90                  95      


His Asp Ser Lys Thr Gly Val Asp Pro Asp Ser Ala Gln Arg Leu Ile 
            100                 105                 110         


Arg Glu Leu Tyr Ser Leu Leu Asp Phe Leu Arg Asn Asp Phe Ser His 
        115                 120                 125             


Asn Arg Leu Asp Gly Thr Thr Phe Glu His Leu Glu Val Ser Pro Asp 
    130                 135                 140                 


Ile Ser Ser Phe Ile Thr Gly Thr Tyr Ser Leu Ala Cys Gly Arg Ala 
145                 150                 155                 160 


Gln Ser Arg Phe Ala Asp Phe Phe Lys Pro Asp Asp Phe Val Leu Ala 
                165                 170                 175     


Lys Asn Arg Lys Glu Gln Leu Ile Ser Val Ala Asp Gly Lys Glu Cys 
            180                 185                 190         


Leu Thr Val Ser Gly Leu Ala Phe Phe Ile Cys Leu Phe Leu Asp Arg 
        195                 200                 205             


Glu Gln Ala Ser Gly Met Leu Ser Arg Ile Arg Gly Phe Lys Arg Thr 
    210                 215                 220                 


Asp Glu Asn Trp Ala Arg Ala Val His Glu Thr Phe Cys Asp Leu Cys 
225                 230                 235                 240 


Ile Arg His Pro His Asp Arg Leu Glu Ser Ser Asn Thr Lys Glu Ala 
                245                 250                 255     


Leu Leu Leu Asp Met Leu Asn Glu Leu Asn Arg Cys Pro Arg Ile Leu 
            260                 265                 270         


Tyr Asp Met Leu Pro Glu Glu Glu Arg Ala Gln Phe Leu Pro Ala Leu 
        275                 280                 285             


Asp Glu Asn Ser Met Asn Asn Leu Ser Glu Asn Ser Leu Asn Glu Glu 
    290                 295                 300                 


Ser Arg Leu Leu Trp Asp Gly Ser Ser Asp Trp Ala Glu Ala Leu Thr 
305                 310                 315                 320 


Lys Arg Ile Arg His Gln Asp Arg Phe Pro Tyr Leu Met Leu Arg Phe 
                325                 330                 335     


Ile Glu Glu Met Asp Leu Leu Lys Gly Ile Arg Phe Arg Val Asp Leu 
            340                 345                 350         


Gly Glu Ile Glu Leu Asp Ser Tyr Ser Lys Lys Val Gly Arg Asn Gly 
        355                 360                 365             


Glu Tyr Asp Arg Thr Ile Thr Asp His Ala Leu Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Asp Phe Gln Asn Glu Glu Glu Val Ser Arg Met Ile Ser Gly Glu 
385                 390                 395                 400 


Ala Ser Tyr Pro Val Arg Phe Ser Leu Phe Ala Pro Arg Tyr Ala Ile 
                405                 410                 415     


Tyr Asp Asn Lys Ile Gly Tyr Cys His Thr Ser Asp Pro Val Tyr Pro 
            420                 425                 430         


Lys Ser Lys Thr Gly Glu Lys Arg Ala Leu Ser Asn Pro Arg Ser Met 
        435                 440                 445             


Gly Phe Ile Ser Val His Asp Leu Arg Lys Leu Leu Leu Met Glu Leu 
    450                 455                 460                 


Leu Cys Glu Gly Ser Phe Ser Arg Met Gln Ser Asp Phe Leu Arg Lys 
465                 470                 475                 480 


Ala Asn Arg Ile Leu Asp Glu Thr Ala Glu Gly Lys Leu Gln Phe Ser 
                485                 490                 495     


Ala Leu Phe Pro Glu Met Arg His Arg Phe Ile Pro Pro Gln Asn Pro 
            500                 505                 510         


Lys Ser Lys Asp Arg Arg Glu Lys Ala Glu Thr Thr Leu Glu Lys Tyr 
        515                 520                 525             


Lys Gln Glu Ile Lys Gly Arg Lys Asp Lys Leu Asn Ser Gln Leu Leu 
    530                 535                 540                 


Ser Ala Phe Asp Met Asp Gln Arg Gln Leu Pro Ser Arg Leu Leu Asp 
545                 550                 555                 560 


Glu Trp Met Asn Ile Arg Pro Ala Ser His Ser Val Lys Leu Arg Thr 
                565                 570                 575     


Tyr Val Lys Gln Leu Asn Glu Asp Cys Arg Leu Arg Leu Arg Lys Phe 
            580                 585                 590         


Arg Lys Asp Gly Asp Gly Lys Ala Arg Ala Ile Pro Leu Val Gly Glu 
        595                 600                 605             


Met Ala Thr Phe Leu Ser Gln Asp Ile Val Arg Met Ile Ile Ser Glu 
    610                 615                 620                 


Glu Thr Lys Lys Leu Ile Thr Ser Ala Tyr Tyr Asn Glu Met Gln Arg 
625                 630                 635                 640 


Ser Leu Ala Gln Tyr Ala Gly Glu Glu Asn Arg Arg Gln Phe Arg Ala 
                645                 650                 655     


Ile Val Ala Glu Leu Arg Leu Leu Asp Pro Ser Ser Gly His Pro Phe 
            660                 665                 670         


Leu Ser Ala Thr Met Glu Thr Ala His Arg Tyr Thr Glu Asp Phe Tyr 
        675                 680                 685             


Lys Cys Tyr Leu Glu Lys Lys Arg Glu Trp Leu Ala Lys Thr Phe Tyr 
    690                 695                 700                 


Arg Pro Glu Gln Asp Glu Asn Thr Lys Arg Arg Ile Ser Val Phe Phe 
705                 710                 715                 720 


Val Pro Asp Gly Glu Ala Arg Lys Leu Leu Pro Leu Leu Ile Arg Arg 
                725                 730                 735     


Arg Met Lys Glu Gln Asn Asp Leu Gln Asp Trp Ile Arg Asn Lys Gln 
            740                 745                 750         


Ala His Pro Ile Asp Leu Pro Ser His Leu Phe Asp Ser Lys Ile Met 
        755                 760                 765             


Glu Leu Leu Lys Val Lys Asp Gly Lys Lys Lys Trp Asn Glu Ala Phe 
    770                 775                 780                 


Lys Asp Trp Trp Ser Thr Lys Tyr Pro Asp Gly Met Gln Pro Phe Tyr 
785                 790                 795                 800 


Gly Leu Arg Arg Glu Leu Asn Ile His Gly Lys Ser Val Ser Tyr Ile 
                805                 810                 815     


Pro Ser Asp Gly Lys Lys Phe Ala Asp Cys Tyr Thr His Leu Met Glu 
            820                 825                 830         


Lys Thr Val Arg Asp Lys Lys Arg Glu Leu Arg Thr Ala Gly Lys Pro 
        835                 840                 845             


Val Pro Pro Asp Leu Ala Ala Asp Ile Lys Arg Ser Phe His Arg Ala 
    850                 855                 860                 


Val Asn Glu Arg Glu Phe Met Leu Arg Leu Val Gln Glu Asp Asp Arg 
865                 870                 875                 880 


Leu Met Leu Met Ala Ile Asn Lys Met Met Thr Asp Arg Glu Glu Asp 
                885                 890                 895     


Ile Leu Pro Gly Leu Lys Asn Ile Asp Ser Ile Leu Asp Glu Glu Asn 
            900                 905                 910         


Gln Phe Ser Leu Ala Val His Ala Lys Val Leu Glu Lys Glu Gly Glu 
        915                 920                 925             


Gly Gly Asp Asn Ser Leu Ser Leu Val Pro Ala Thr Ile Glu Ile Lys 
    930                 935                 940                 


Ser Lys Arg Lys Asp Trp Ser Lys Tyr Ile Arg Tyr Arg Tyr Asp Arg 
945                 950                 955                 960 


Arg Val Pro Gly Leu Met Ser His Phe Pro Glu His Lys Ala Thr Leu 
                965                 970                 975     


Asp Glu Val Lys Thr Leu Leu Gly Glu Tyr Asp Arg Cys Arg Ile Lys 
            980                 985                 990         


Ile Phe Asp Trp Ala Phe Ala Leu  Glu Gly Ala Ile Met  Ser Asp Arg 
        995                 1000                 1005             


Asp Leu  Lys Pro Tyr Leu His  Glu Ser Ser Ser Arg  Glu Gly Lys 
    1010                 1015                 1020             


Ser Gly  Glu His Ser Thr Leu  Val Lys Met Leu Val  Glu Lys Lys 
    1025                 1030                 1035             


Gly Cys  Leu Thr Pro Asp Glu  Ser Gln Tyr Leu Ile  Leu Ile Arg 
    1040                 1045                 1050             


Asn Lys  Ala Ala His Asn Gln  Phe Pro Cys Ala Ala  Glu Met Pro 
    1055                 1060                 1065             


Leu Ile  Tyr Arg Asp Val Ser  Ala Lys Val Gly Ser  Ile Glu Gly 
    1070                 1075                 1080             


Ser Ser  Ala Lys Asp Leu Pro  Glu Gly Ser Ser Leu  Val Asp Ser 
    1085                 1090                 1095             


Leu Trp  Lys Lys Tyr Glu Met  Ile Ile Arg Lys Ile  Leu Pro Ile 
    1100                 1105                 1110             


Leu Asp  Pro Glu Asn Arg Phe  Phe Gly Lys Leu Leu  Asn Asn Met 
    1115                 1120                 1125             


Ser Gln  Pro Ile Asn Asp Leu  
    1130                 1135 


<210>  1411
<211>  1119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1411

Met Thr Glu Gln Asn Glu Lys Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Thr His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Cys Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Gly Thr Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Ala Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Phe Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Glu Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Asp Glu Ile Asn Thr Arg Asp 
    530                 535                 540                 


Glu Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Gly Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu Arg Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Ser Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Tyr Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Ser Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Leu Ala Lys Leu Lys Lys Glu Ile Leu Glu Ala 
        835                 840                 845             


Lys Glu His Pro Tyr His Asp Phe Lys Ser Trp Gln Lys Phe Glu Arg 
    850                 855                 860                 


Glu Leu Arg Leu Val Lys Asn Gln Asp Ile Ile Thr Trp Met Met Cys 
865                 870                 875                 880 


Arg Asp Leu Met Glu Glu Asn Lys Val Glu Gly Leu Asp Thr Gly Thr 
                885                 890                 895     


Leu Tyr Leu Lys Asp Ile Arg Thr Asp Val His Glu Gln Gly Ser Leu 
            900                 905                 910         


Asn Val Leu Asn Arg Val Lys Pro Met Arg Leu Pro Val Val Val Tyr 
        915                 920                 925             


Arg Ala Asp Ser Arg Gly His Val His Lys Glu Gln Ala Pro Leu Ala 
    930                 935                 940                 


Thr Val Tyr Ile Glu Glu Arg Asp Thr Lys Leu Leu Lys Gln Gly Asn 
945                 950                 955                 960 


Phe Lys Ser Phe Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe 
                965                 970                 975     


Val Asp Thr Gly Gly Leu Ala Met Glu Gln Tyr Pro Ile Ser Lys Leu 
            980                 985                 990         


Arg Val Glu Tyr Glu Leu Ala Lys  Tyr Gln Thr Ala Arg  Val Cys Ala 
        995                 1000                 1005             


Phe Glu  Gln Thr Leu Glu Leu  Glu Glu Ser Leu Leu  Thr Arg Tyr 
    1010                 1015                 1020             


Pro His  Leu Pro Asp Glu Asn  Phe Arg Lys Met Leu  Glu Ser Cys 
    1025                 1030                 1035             


Ser Asp  Pro Leu Leu Asp Lys  Trp Pro Asp Leu His  Gly Lys Val 
    1040                 1045                 1050             


Arg Leu  Leu Ile Ala Val Arg  Asn Ala Phe Ser His  Asn Gln Tyr 
    1055                 1060                 1065             


Pro Met  Tyr Asp Glu Ala Val  Phe Ser Ser Ile Arg  Lys Tyr Asp 
    1070                 1075                 1080             


Pro Ser  Ser Pro Asp Ala Ile  Glu Glu Arg Met Gly  Leu Asn Ile 
    1085                 1090                 1095             


Ala His  Arg Leu Ser Glu Glu  Val Lys Gln Ala Lys  Glu Met Ala 
    1100                 1105                 1110             


Glu Arg  Ile Ile Gln Ala 
    1115                 


<210>  1412
<211>  1119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1412

Met Thr Glu Gln Asn Glu Arg Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Ala His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Met Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Cys Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Gly Thr Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Ala Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asn Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln Leu Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Phe Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Glu Glu Val 
            500                 505                 510         


Ser Ala Glu Lys Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Asp Glu Ile Asn Thr Arg Asp 
    530                 535                 540                 


Glu Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Glu Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Ser Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Tyr Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Ser Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Leu Ala Lys Leu Lys Lys Glu Ile Leu Glu Ala 
        835                 840                 845             


Lys Glu His Pro Tyr His Asp Phe Lys Ser Trp Gln Lys Phe Glu Arg 
    850                 855                 860                 


Glu Leu Arg Leu Val Lys Asn Gln Asp Ile Ile Thr Trp Met Met Cys 
865                 870                 875                 880 


Arg Asp Leu Met Glu Glu Asn Lys Val Glu Gly Leu Asp Thr Gly Thr 
                885                 890                 895     


Leu Tyr Leu Lys Asp Ile Arg Thr Asp Val His Glu Gln Gly Ser Leu 
            900                 905                 910         


Asn Val Leu Asn Arg Val Lys Pro Met Arg Leu Pro Val Val Val Tyr 
        915                 920                 925             


Arg Ala Asp Ser Arg Gly His Val His Lys Glu Gln Ala Pro Leu Ala 
    930                 935                 940                 


Thr Val Tyr Ile Glu Glu Arg Asp Thr Lys Leu Leu Lys Gln Gly Asn 
945                 950                 955                 960 


Phe Lys Ser Phe Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe 
                965                 970                 975     


Val Asp Thr Gly Gly Leu Ala Met Glu Gln Tyr Pro Ile Ser Lys Leu 
            980                 985                 990         


Arg Val Glu Tyr Glu Leu Ala Lys  Tyr Gln Thr Ala Arg  Val Cys Ala 
        995                 1000                 1005             


Phe Glu  Gln Thr Leu Glu Leu  Glu Glu Ser Leu Leu  Thr Arg Tyr 
    1010                 1015                 1020             


Pro His  Leu Pro Asp Glu Asn  Phe Arg Lys Met Leu  Glu Ser Trp 
    1025                 1030                 1035             


Ser Asp  Pro Leu Leu Asp Lys  Trp Pro Asp Leu His  Arg Lys Val 
    1040                 1045                 1050             


Arg Leu  Leu Ile Ala Val Arg  Asn Ala Phe Ser His  Asn Gln Tyr 
    1055                 1060                 1065             


Pro Met  Tyr Asp Glu Ala Val  Phe Ser Ser Ile Arg  Lys Tyr Asp 
    1070                 1075                 1080             


Pro Ser  Ser Pro Asp Ala Ile  Glu Glu Arg Met Gly  Leu Asn Ile 
    1085                 1090                 1095             


Ala His  Arg Leu Ser Glu Glu  Val Lys Gln Ala Lys  Glu Thr Val 
    1100                 1105                 1110             


Glu Arg  Ile Ile Gln Val 
    1115                 


<210>  1413
<211>  1135
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1413

Met Asn Thr Val Pro Ala Ser Glu Asn Lys Gly Gln Ser Arg Thr Val 
1               5                   10                  15      


Glu Asp Asp Pro Gln Tyr Phe Gly Leu Tyr Leu Asn Leu Ala Arg Glu 
            20                  25                  30          


Asn Leu Ile Glu Val Glu Ser His Val Arg Ile Lys Phe Gly Lys Lys 
        35                  40                  45              


Lys Leu Asn Glu Glu Ser Leu Lys Gln Ser Leu Leu Cys Asp His Leu 
    50                  55                  60                  


Leu Ser Val Asp Arg Trp Thr Lys Val Tyr Gly His Ser Arg Arg Tyr 
65                  70                  75                  80  


Leu Pro Phe Leu His Tyr Phe Asp Pro Asp Ser Gln Ile Glu Lys Asp 
                85                  90                  95      


His Asp Ser Lys Thr Gly Val Asp Pro Asp Ser Ala Gln Arg Leu Ile 
            100                 105                 110         


Arg Glu Leu Tyr Ser Leu Leu Asp Phe Leu Arg Asn Asp Phe Ser His 
        115                 120                 125             


Asn Arg Leu Asp Gly Thr Thr Phe Glu His Leu Glu Val Ser Pro Asp 
    130                 135                 140                 


Ile Ser Ser Phe Ile Thr Gly Thr Tyr Ser Leu Ala Cys Gly Arg Ala 
145                 150                 155                 160 


Gln Ser Arg Phe Ala Asp Phe Phe Lys Pro Asp Asp Phe Val Leu Ala 
                165                 170                 175     


Lys Asn Arg Lys Glu Gln Leu Ile Ser Val Ala Asp Gly Lys Glu Tyr 
            180                 185                 190         


Leu Thr Val Ser Gly Leu Ala Phe Phe Ile Cys Leu Phe Leu Asp Arg 
        195                 200                 205             


Glu Gln Ala Ser Gly Met Leu Ser Arg Ile Arg Gly Phe Lys Arg Thr 
    210                 215                 220                 


Asp Glu Asn Trp Ala Arg Ala Val His Glu Thr Phe Cys Asp Leu Cys 
225                 230                 235                 240 


Ile Arg His Pro His Asp Arg Leu Glu Ser Ser Asn Thr Lys Glu Ala 
                245                 250                 255     


Leu Leu Leu Asp Met Leu Asn Glu Leu Asn Arg Cys Pro Arg Ile Leu 
            260                 265                 270         


Tyr Asp Met Leu Pro Glu Glu Glu Arg Ala Gln Phe Leu Pro Ala Leu 
        275                 280                 285             


Asp Glu Asn Ser Met Asn Asn Leu Ser Glu Asn Ser Leu Asn Glu Glu 
    290                 295                 300                 


Ser Arg Leu Leu Trp Asp Gly Ser Ser Asp Trp Ala Glu Ala Leu Thr 
305                 310                 315                 320 


Lys Arg Ile Arg His Gln Asp Arg Phe Pro Tyr Leu Met Leu Arg Phe 
                325                 330                 335     


Ile Glu Glu Met Asp Leu Leu Lys Gly Ile Arg Phe Arg Val Asp Leu 
            340                 345                 350         


Gly Glu Ile Glu Leu Asp Ser Tyr Ser Lys Lys Val Gly Arg Asn Gly 
        355                 360                 365             


Glu Tyr Asp Arg Thr Ile Thr Asp His Ala Leu Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Asp Phe Gln Asn Glu Glu Glu Val Ser Arg Met Ile Ser Gly Glu 
385                 390                 395                 400 


Ala Ser Tyr Pro Val Arg Phe Ser Leu Phe Ala Pro Arg Tyr Ala Ile 
                405                 410                 415     


Tyr Asp Asn Lys Ile Gly Tyr Cys His Thr Ser Asp Pro Val Tyr Pro 
            420                 425                 430         


Lys Ser Lys Thr Gly Glu Lys Arg Ala Leu Ser Asn Pro Arg Ser Met 
        435                 440                 445             


Gly Phe Ile Ser Val His Asp Leu Arg Lys Leu Leu Leu Met Glu Leu 
    450                 455                 460                 


Leu Cys Glu Gly Ser Phe Ser Arg Met Gln Ser Gly Phe Leu Arg Lys 
465                 470                 475                 480 


Ala Asn Arg Ile Leu Asp Glu Thr Ala Glu Gly Lys Leu Gln Phe Ser 
                485                 490                 495     


Ala Leu Phe Pro Glu Met Arg His Arg Phe Ile Pro Pro Gln Asn Pro 
            500                 505                 510         


Lys Ser Lys Asp Arg Arg Glu Lys Ala Glu Thr Thr Leu Glu Lys Tyr 
        515                 520                 525             


Lys Gln Glu Ile Lys Gly Arg Lys Asp Lys Leu Asn Ser Gln Leu Leu 
    530                 535                 540                 


Ser Ala Phe Asp Met Asp Gln Arg Gln Leu Pro Ser Arg Leu Leu Asp 
545                 550                 555                 560 


Glu Trp Met Asn Ile Arg Pro Ala Ser His Ser Val Lys Leu Arg Thr 
                565                 570                 575     


Tyr Val Lys Gln Leu Asn Glu Asp Cys Arg Leu Arg Leu Arg Lys Phe 
            580                 585                 590         


Arg Lys Asp Gly Asp Gly Lys Ala Arg Ala Ile Pro Leu Val Gly Glu 
        595                 600                 605             


Met Ala Thr Phe Leu Ser Gln Asp Ile Val Arg Met Ile Ile Ser Glu 
    610                 615                 620                 


Glu Thr Lys Lys Leu Ile Thr Ser Ala Tyr Tyr Asn Glu Met Gln Arg 
625                 630                 635                 640 


Ser Leu Ala Gln Tyr Ala Gly Glu Glu Asn Arg Arg Gln Phe Arg Ala 
                645                 650                 655     


Ile Val Ala Glu Leu Arg Leu Leu Asp Pro Ser Ser Gly His Pro Phe 
            660                 665                 670         


Leu Ser Ala Thr Met Glu Thr Ala His Arg Tyr Thr Glu Asp Phe Tyr 
        675                 680                 685             


Lys Cys Tyr Leu Glu Lys Lys Arg Glu Trp Leu Ala Lys Thr Phe Tyr 
    690                 695                 700                 


Arg Pro Glu Gln Asp Glu Asn Thr Lys Arg Arg Ile Ser Val Phe Phe 
705                 710                 715                 720 


Val Pro Asp Gly Glu Ala Arg Lys Leu Leu Pro Leu Leu Ile Arg Arg 
                725                 730                 735     


Arg Met Lys Glu Gln Asn Asp Leu Gln Asp Trp Ile Arg Asn Lys Gln 
            740                 745                 750         


Ala His Pro Ile Asp Leu Pro Ser His Leu Phe Asp Ser Lys Val Met 
        755                 760                 765             


Glu Leu Leu Lys Val Lys Asp Gly Lys Lys Lys Trp Asn Glu Ala Phe 
    770                 775                 780                 


Lys Asp Trp Trp Ser Thr Lys Tyr Pro Asp Gly Met Gln Pro Phe Tyr 
785                 790                 795                 800 


Gly Leu Arg Arg Glu Leu Asn Ile His Gly Lys Ser Val Ser Tyr Ile 
                805                 810                 815     


Pro Ser Asp Gly Lys Lys Phe Ala Asp Cys Tyr Thr His Leu Met Glu 
            820                 825                 830         


Lys Thr Val Gln Asp Lys Lys Arg Glu Leu Arg Thr Ala Gly Lys Pro 
        835                 840                 845             


Val Pro Pro Asp Leu Ala Ala Asp Ile Lys Arg Ser Phe His Arg Ala 
    850                 855                 860                 


Val Asn Glu Arg Glu Phe Met Leu Arg Leu Val Gln Glu Asp Asp Arg 
865                 870                 875                 880 


Leu Met Leu Met Ala Ile Asn Lys Met Met Thr Asp Arg Glu Glu Asp 
                885                 890                 895     


Ile Leu Pro Gly Leu Lys Asn Ile Asp Ser Ile Leu Asp Lys Glu Asn 
            900                 905                 910         


Gln Phe Ser Leu Ala Val His Ala Lys Val Leu Glu Lys Glu Gly Glu 
        915                 920                 925             


Gly Gly Asp Asn Pro Leu Ser Leu Val Pro Ala Thr Ile Glu Ile Lys 
    930                 935                 940                 


Ser Lys Arg Lys Asp Trp Ser Lys Tyr Ile Arg Tyr Arg Tyr Asp Arg 
945                 950                 955                 960 


Arg Val Pro Gly Leu Met Ser His Phe Pro Glu His Lys Ala Thr Leu 
                965                 970                 975     


Asp Glu Val Lys Thr Leu Leu Gly Glu Tyr Asp Arg Cys Arg Ile Lys 
            980                 985                 990         


Ile Phe Asp Trp Ala Phe Ala Leu  Glu Gly Ala Ile Met  Ser Asp Arg 
        995                 1000                 1005             


Asp Leu  Lys Pro Tyr Leu His  Glu Ser Ser Ser Arg  Glu Gly Lys 
    1010                 1015                 1020             


Ser Gly  Glu His Ser Thr Leu  Val Lys Met Leu Val  Glu Lys Lys 
    1025                 1030                 1035             


Gly Cys  Leu Thr Pro Asp Glu  Ser Gln Tyr Leu Ile  Leu Ile Arg 
    1040                 1045                 1050             


Asn Lys  Ala Ala His Asn Gln  Phe Pro Cys Ala Ala  Glu Met Pro 
    1055                 1060                 1065             


Leu Ile  Tyr Arg Asp Val Ser  Ala Lys Val Gly Ser  Ile Glu Gly 
    1070                 1075                 1080             


Ser Ser  Ala Lys Asp Leu Pro  Glu Gly Ser Ser Leu  Val Asp Ser 
    1085                 1090                 1095             


Leu Trp  Lys Lys Tyr Glu Met  Ile Ile Arg Lys Ile  Leu Pro Ile 
    1100                 1105                 1110             


Leu Asp  Pro Glu Asn Arg Phe  Phe Gly Lys Leu Leu  Asn Asn Met 
    1115                 1120                 1125             


Ser Gln  Pro Ile Asn Asp Leu  
    1130                 1135 


<210>  1414
<211>  1175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1414

Met Thr Glu Gln Asn Glu Arg Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Thr His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Tyr Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Glu Lys Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Thr Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Ile Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Ala 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Leu Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Glu Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Gly Glu Ile Asp Thr Leu Asp 
    530                 535                 540                 


Arg Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Glu Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Ser Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Leu Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asn Tyr Pro Phe Asn Val Gly Asn Ile Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Asp Leu Glu Ala Trp Ser Gln Ser Thr Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Ala Gly Ile Lys Tyr Ala Ser Pro Gly Asn 
    850                 855                 860                 


Lys Lys Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Glu Thr 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Lys Ala Asp Lys Ile Asn Leu Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Ala Lys Glu His Pro Tyr Leu Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asp Ile Arg Thr 
945                 950                 955                 960 


Asp Val Gln Glu Gln Gly Ser Leu Asn Val Leu Asn His Val Lys Pro 
                965                 970                 975     


Met Arg Leu Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val 
            980                 985                 990         


His Lys Glu Glu Ala Pro Leu Ala  Thr Val Tyr Ile Glu  Glu Arg Asp 
        995                 1000                 1005             


Thr Lys  Leu Leu Lys Gln Gly  Asn Phe Lys Ser Phe  Val Lys Asp 
    1010                 1015                 1020             


Arg Arg  Leu Asn Gly Leu Phe  Ser Phe Val Asp Thr  Gly Ala Leu 
    1025                 1030                 1035             


Ala Met  Glu Gln Tyr Pro Ile  Ser Lys Leu Arg Val  Glu Tyr Glu 
    1040                 1045                 1050             


Leu Ala  Lys Tyr Gln Thr Ala  Arg Val Cys Ala Phe  Glu Gln Thr 
    1055                 1060                 1065             


Leu Glu  Leu Glu Glu Ser Leu  Leu Thr Arg Tyr Pro  His Leu Pro 
    1070                 1075                 1080             


Asp Lys  Asn Phe Arg Lys Met  Leu Glu Ser Trp Ser  Asp Pro Leu 
    1085                 1090                 1095             


Leu Asp  Lys Trp Pro Asp Leu  His Arg Lys Val Arg  Leu Leu Ile 
    1100                 1105                 1110             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1115                 1120                 1125             


Glu Ala  Val Phe Ser Ser Ile  Arg Lys Tyr Asp Pro  Ser Ser Pro 
    1130                 1135                 1140             


Asp Ala  Ile Glu Glu Arg Met  Gly Leu Asn Ile Ala  His Arg Leu 
    1145                 1150                 1155             


Ser Glu  Glu Val Lys Gln Ala  Lys Glu Thr Val Glu  Arg Ile Ile 
    1160                 1165                 1170             


Gln Ala  
    1175 


<210>  1415
<211>  1175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1415

Met Thr Glu Gln Asn Glu Arg Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Phe Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Ala His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Ala 
        195                 200                 205             


Arg Cys Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Glu Lys Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Ala Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Trp Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Leu Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Glu Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Gly Glu Ile Asp Thr Leu Asp 
    530                 535                 540                 


Arg Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Gly Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Leu Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Ser Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ile Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Asp Leu Glu Ala Trp Ser Gln Ser Thr Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Ala Gly Ile Lys Tyr Ala Ser Pro Gly Asn 
    850                 855                 860                 


Lys Lys Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Glu Thr 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Lys Ala Asp Lys Ile Asn Leu Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Ala Lys Glu His Pro Tyr Leu Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asp Ile Arg Thr 
945                 950                 955                 960 


Asp Val Gln Glu Gln Gly Ser Leu Asn Val Leu Asn His Val Lys Pro 
                965                 970                 975     


Met Arg Leu Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val 
            980                 985                 990         


His Lys Glu Glu Ala Pro Leu Ala  Thr Val Tyr Ile Glu  Glu Arg Asp 
        995                 1000                 1005             


Thr Lys  Leu Leu Lys Gln Gly  Asn Phe Lys Ser Phe  Val Lys Asp 
    1010                 1015                 1020             


Arg Arg  Leu Asn Gly Leu Phe  Ser Phe Val Asp Thr  Gly Ala Leu 
    1025                 1030                 1035             


Ala Met  Glu Gln Tyr Pro Ile  Ser Lys Leu Arg Val  Glu Tyr Glu 
    1040                 1045                 1050             


Leu Ala  Lys Tyr Gln Thr Ala  Arg Val Cys Ala Phe  Glu Gln Thr 
    1055                 1060                 1065             


Leu Glu  Leu Glu Glu Ser Leu  Leu Thr Arg Tyr Pro  His Leu Pro 
    1070                 1075                 1080             


Asp Lys  Asn Phe Arg Lys Met  Leu Glu Ser Trp Ser  Asp Pro Leu 
    1085                 1090                 1095             


Leu Asp  Lys Trp Pro Asp Leu  His Arg Lys Val Arg  Leu Leu Ile 
    1100                 1105                 1110             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1115                 1120                 1125             


Glu Ala  Val Phe Ser Ser Ile  Arg Lys Tyr Asp Pro  Ser Ser Pro 
    1130                 1135                 1140             


Asp Ala  Ile Glu Glu Arg Met  Gly Leu Asn Ile Ala  His Arg Leu 
    1145                 1150                 1155             


Ser Glu  Glu Val Lys Gln Ala  Lys Glu Thr Val Glu  Arg Ile Ile 
    1160                 1165                 1170             


Gln Ala  
    1175 


<210>  1416
<211>  1175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1416

Met Thr Glu Gln Asn Glu Lys Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Phe Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Ala His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Tyr Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Gly Thr Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Thr Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Ala 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Phe Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Asp Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Gly Glu Ile Asp Thr Leu Asp 
    530                 535                 540                 


Arg Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Gly Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Tyr Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asn Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Asp Leu Glu Ala Trp Ser Gln Ser Ala Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Ala Gly Ile Glu Asn Ala Ser Arg Glu Asn 
    850                 855                 860                 


Lys Lys Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Lys Ala 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Lys Ala Asp Lys Ile Asn Ile Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Ala Lys Glu His Pro Tyr His Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asp Ile Arg Thr 
945                 950                 955                 960 


Asp Val His Glu Gln Gly Ser Leu Asn Val Leu Asn Arg Val Lys Pro 
                965                 970                 975     


Met Arg Leu Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val 
            980                 985                 990         


His Lys Glu Gln Ala Pro Leu Ala  Thr Val Tyr Ile Glu  Glu Arg Asp 
        995                 1000                 1005             


Thr Lys  Leu Leu Lys Gln Gly  Asn Phe Lys Ser Phe  Val Lys Asp 
    1010                 1015                 1020             


Arg Arg  Leu Asn Gly Leu Phe  Ser Phe Val Asp Thr  Gly Ala Leu 
    1025                 1030                 1035             


Ala Met  Glu Gln Tyr Pro Ile  Ser Lys Leu Arg Val  Glu Tyr Glu 
    1040                 1045                 1050             


Leu Ala  Lys Tyr Gln Thr Ala  Arg Val Cys Ala Phe  Glu Gln Thr 
    1055                 1060                 1065             


Leu Glu  Leu Glu Glu Ser Leu  Leu Thr Arg Tyr Pro  His Leu Pro 
    1070                 1075                 1080             


Asp Lys  Asn Phe Arg Lys Met  Leu Glu Ser Trp Ser  Asp Pro Leu 
    1085                 1090                 1095             


Leu Asp  Lys Trp Pro Asp Leu  His Arg Lys Val Arg  Leu Leu Ile 
    1100                 1105                 1110             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1115                 1120                 1125             


Glu Ala  Val Phe Ser Ser Ile  Arg Lys Tyr Asp Pro  Ser Ser Pro 
    1130                 1135                 1140             


Asp Ala  Ile Glu Glu Arg Met  Gly Leu Asn Ile Ala  His Arg Leu 
    1145                 1150                 1155             


Ser Glu  Glu Val Lys Gln Ala  Lys Glu Met Ala Glu  Arg Ile Ile 
    1160                 1165                 1170             


Gln Ala  
    1175 


<210>  1417
<211>  1199
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1417

Met Asn Thr Phe Ile Asp Ser Phe Ile Arg Arg Val Gln Ile Gln Asn 
1               5                   10                  15      


Gln Asn Gln Ser Trp Pro Lys Arg Pro Lys Tyr Val Arg Pro Val Glu 
            20                  25                  30          


Asn Ile Arg Pro Asp Asp Leu Ala Phe Gln Ser His Phe Thr Ala Tyr 
        35                  40                  45              


Leu Asn Met Ala Arg Gln Asn Cys Cys Ile Ile Leu Gly His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Gly Phe Lys Ala Ser Ser Val Lys Asp Thr Thr Leu Thr 
65                  70                  75                  80  


Ser Ser Pro Leu Leu Gly Gln Asn Gly Leu Leu Ser Pro Lys Lys Glu 
                85                  90                  95      


Val Ser Asp Leu Ile Arg Gly Arg Leu Leu Ser Ala Phe Pro Met Leu 
            100                 105                 110         


Asp Pro Met Ile Arg Tyr Arg Lys Ala Val Asp Lys Glu Lys Asp Asp 
        115                 120                 125             


Tyr Ala Arg Ile Ile Ile Thr Ser Glu Asp Val Ser Glu Met Leu Arg 
    130                 135                 140                 


Asp Leu Leu Asp Val Leu Ser Tyr Tyr Arg Asp Met Ala Ser His Val 
145                 150                 155                 160 


Val Phe Asn Asp Asp Arg Ser Val Ser Ala Glu Phe Ala Ser Lys Glu 
                165                 170                 175     


Lys Lys Val Ala Glu Cys Leu Asn Tyr Met Met Thr Val Ser Leu Arg 
            180                 185                 190         


Ile Val Lys Asp Arg Phe Ser Leu Ala Val Ser Asp Leu Asp Phe Tyr 
        195                 200                 205             


Asn Arg Asn Arg Tyr Met Met Val Asn Arg Lys Pro Leu Leu Asn Ala 
    210                 215                 220                 


Gly Phe Ala His Ala Val Arg Thr Glu Asp Tyr Arg Leu Thr Leu Met 
225                 230                 235                 240 


Gly Leu Val Leu Leu Cys Cys Gln Phe Ile Glu Lys Gln Tyr Ala Ser 
                245                 250                 255     


Met Phe Phe Asp Ala Leu Asp Lys His Ser Asn Gly Ala Arg Phe Tyr 
            260                 265                 270         


Gly Ile Ala Asp Ala Met Pro Met Val Asn Val Gly Thr Lys Asp Lys 
        275                 280                 285             


Pro Lys Lys Ile Pro Met Tyr Thr Gly Asp Glu Ala Gln Lys Gln Val 
    290                 295                 300                 


Gln Lys Gln Arg Met Ala Leu Arg Glu Ala Tyr Ser Val Tyr Arg Val 
305                 310                 315                 320 


Arg Ile Pro Lys Glu Arg Leu Glu Ser Thr Arg Ser Asp Met Ala Leu 
                325                 330                 335     


Ala Leu Asp Ile Leu Asn Glu Leu Gly Lys Cys Pro Glu Glu Leu Phe 
            340                 345                 350         


Glu His Leu Ser Pro Glu Asp Arg Glu Ser Phe Lys Asn Glu Glu Gly 
        355                 360                 365             


Val Leu Met Lys Arg Tyr Ser Asp Arg Phe Pro Gln Leu Ala Leu Arg 
    370                 375                 380                 


Trp Leu Asp Glu Asn Glu Lys Phe Asn Asn Leu Arg Phe His Val Thr 
385                 390                 395                 400 


Phe Gly Lys Tyr Arg Trp Leu Phe Cys Gln Asp Lys Lys Cys Ala Asp 
                405                 410                 415     


Gly Ser Val Arg Pro Arg Trp Leu Gln Lys Glu Leu Asn Gly Phe Gly 
            420                 425                 430         


Arg Ile Gln Thr Val Glu Arg Lys Arg Thr Gly Leu Glu Pro Gly Trp 
        435                 440                 445             


Asp Gly Thr Gly Leu Ile Arg Lys Phe Glu Glu Val Val Thr Asp Glu 
    450                 455                 460                 


Val Gln Lys Glu Pro Tyr Ile Thr Asp Phe Arg Thr Gln Tyr Leu Phe 
465                 470                 475                 480 


Asn Arg Asp Lys Ile Gly Ile Ser Leu Ser Glu Tyr Met Pro Gly Ile 
                485                 490                 495     


Gly Asp Ile His Ser Gly Lys Glu Trp Gly Lys His Ala Gly Val Pro 
            500                 505                 510         


Asp Phe Tyr Leu Ser Val Tyr Asp Ile Pro Ala Met Leu Phe Leu Thr 
        515                 520                 525             


Trp Leu Leu Gly Lys Asn Ser Ser Ala Val Glu Lys Leu Leu Ala Asn 
    530                 535                 540                 


Cys Lys Ala Ala Tyr Met Lys Leu Phe Asp Asp Leu Ala Lys Gly Lys 
545                 550                 555                 560 


Trp Glu Gly Glu Arg Asn Val Ser Asp Tyr Cys Ala Gly Glu Gly Thr 
                565                 570                 575     


Val Arg Tyr Thr Leu Arg Trp Tyr Asp Val Pro Met Lys Ile Arg Arg 
            580                 585                 590         


Lys Met Pro Leu Leu Gly Gly Asp Arg Asp Phe Glu Glu Lys Lys Ser 
        595                 600                 605             


Phe Glu Thr Leu Ala Gln Glu Ala Leu Thr Arg Met Leu Gln Arg Thr 
    610                 615                 620                 


Glu Asn Gln Leu Glu Lys Phe Asp Arg Asp Leu Ala Ala Ala Arg Asp 
625                 630                 635                 640 


Leu Lys Ala Asn Lys Gln Gly Lys Asp Arg Phe Val Asp Ile Arg Ala 
                645                 650                 655     


Gly Ser Leu Ala Thr Phe Leu Ala Arg Asp Ile Val Arg Leu Met Pro 
            660                 665                 670         


Val Ser Asp Asn Gly Arg Asn Lys Pro Thr Gly Leu Asn Tyr Ser Ile 
        675                 680                 685             


Val Gln Lys Ala Ile Ala Thr Tyr Lys Pro Ser Glu Gly Gly Leu Asp 
    690                 695                 700                 


Thr Leu Thr Gly Val Phe Arg Asp Ala Arg Ile Ile Gly Val Lys Gly 
705                 710                 715                 720 


Gly Ser His Pro Phe Leu Glu Arg Leu Leu Val Glu Lys Lys Pro Ser 
                725                 730                 735     


Ser Val Leu Ala Leu Tyr Arg His Tyr Leu Glu Tyr Arg Lys Glu Tyr 
            740                 745                 750         


Leu Lys Lys Ala Leu Glu Asp Glu Asn Lys Ala Glu Leu Lys Asn Leu 
        755                 760                 765             


Pro Phe Leu Lys Ser Gly Arg Gln Lys Tyr Ala Val Asp Gln Ala Asp 
    770                 775                 780                 


Tyr Ala Arg Arg Leu Ala Glu Ser Tyr Arg Asn Cys Pro Ile Tyr Leu 
785                 790                 795                 800 


Pro Thr Gly Ile Phe Thr Asp Met Leu Lys Asp Gln Leu Ala Lys Ile 
                805                 810                 815     


Asp Val Met Lys Pro Val Leu Glu Asn Asp Lys Val Asn Ala Ser Tyr 
            820                 825                 830         


Leu Ile Ala Gln Tyr Phe Glu Lys Val Glu His Asp Ser Glu Gln Pro 
        835                 840                 845             


Leu Tyr Arg Leu Lys Arg Asn Tyr Arg Val Phe Asp Leu Leu Glu Phe 
    850                 855                 860                 


Thr Asp Glu Pro Lys Tyr Trp Arg Leu Asn Glu Arg Ser Asp Lys Ala 
865                 870                 875                 880 


Gly Lys Tyr Gly Leu Ala Lys Arg Asn Ile Phe Trp Asn Arg Met Gly 
                885                 890                 895     


Glu Tyr Tyr Lys Gly Leu Lys Lys Phe Tyr Lys Gly Tyr Glu Ser Lys 
            900                 905                 910         


Arg Thr Ala Val Asp Trp Arg Glu Lys Leu Lys Ile Val Glu Ala Glu 
        915                 920                 925             


His Ala Met Trp Asn Arg Leu Lys Asp Ala Ser Gly Glu Ala Arg Leu 
    930                 935                 940                 


Lys Met Lys Asp Gly Val Phe Tyr Ser Arg Leu Leu Ser Ala Arg Lys 
945                 950                 955                 960 


Glu Tyr Asp Asp Cys Glu Arg Ala Leu Arg Arg Leu Lys Val Gln Asp 
                965                 970                 975     


Ile Val Leu Phe Leu Ala Ala Arg Glu Thr Leu Ile Leu Pro Lys Asp 
            980                 985                 990         


Lys Val Phe Arg Leu Lys Asn Leu  Ser Leu Ser Glu Gly  Asn Lys Asn 
        995                 1000                 1005             


Ile Leu  Ser Ser Ala Ile Asp  Glu Phe Ser Val Asp  Val Val Trp 
    1010                 1015                 1020             


Thr Glu  Lys Glu Gly Ala Ala  Lys Val Thr His Ser  Ala Ser Ile 
    1025                 1030                 1035             


Lys Glu  Asn Asp Val Val Ile  Lys Asn Tyr Gly Arg  Met Phe Arg 
    1040                 1045                 1050             


Leu Leu  His Asp Asp Arg Val  Lys Thr Leu Leu Pro  His Ile Tyr 
    1055                 1060                 1065             


Asp Ser  Ala Leu Ser Glu Asn  Ile Thr Gly Asp Arg  Ile Thr Val 
    1070                 1075                 1080             


Lys Asp  Asn Lys Val Ile Ile  Asp Lys Ser Leu Phe  Asp Glu Asp 
    1085                 1090                 1095             


Leu Met  Asn Tyr Asp Leu Arg  Arg His Glu Ile Cys  Glu Ile Ile 
    1100                 1105                 1110             


Leu Arg  Phe Glu Ala Ala Ser  Ile Lys Arg Phe Gly  Leu Asp Gly 
    1115                 1120                 1125             


Arg Val  Asp Phe Lys Ala Ala  Leu Asp Ala Leu Thr  Gly Arg Ser 
    1130                 1135                 1140             


Leu Leu  Asn Asp Glu Asp Ala  Arg Ile Leu Ser Ala  Ile Arg Asn 
    1145                 1150                 1155             


Ala Tyr  Asn His Asn Lys Tyr  Pro Ala Lys Gly Thr  Asp Val Lys 
    1160                 1165                 1170             


Val Asn  Val Met Ala Leu Pro  Lys Leu Thr Glu Asp  Leu Leu Arg 
    1175                 1180                 1185             


Ile Phe  Ser Asp Thr Gly Asn  Asn Arg Val Arg 
    1190                 1195                 


<210>  1418
<211>  1057
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1418

Met Thr Ile Lys Glu Gln Ser His Phe Ala Ala Tyr Tyr Asn Met Ala 
1               5                   10                  15      


Arg His Asn Met Tyr Glu Thr Leu Cys Tyr Ile Ser Lys Ile Ser Gly 
            20                  25                  30          


Ile Gln Glu Gly Glu Asp Asn Lys Glu Ser Lys Ile Glu Asp Met Gln 
        35                  40                  45              


Leu Leu Arg Val Leu Thr Thr Lys Gly His Pro Glu Glu Lys Ile Arg 
    50                  55                  60                  


Ile Glu Lys Leu Ile Tyr Lys His Leu Pro Leu Phe Arg Pro Ala Val 
65                  70                  75                  80  


Glu Asp Leu Arg Lys Lys Ser Lys Glu Asn Val Lys Ser Pro Glu Leu 
                85                  90                  95      


Leu Ala Lys Val Ile Lys Asn Trp Ala Lys Val Ile Thr Tyr Tyr Arg 
            100                 105                 110         


Asp Lys Phe Thr His Tyr Val Phe Ile Asp Lys Arg His Glu Asn Lys 
        115                 120                 125             


Glu Phe Leu Asn Ala Glu Met Ser Val Ala Asn Asp Leu Asn Gln Ile 
    130                 135                 140                 


Phe Thr Ala Ser Ala Arg Val Ile Lys Glu Arg Phe Gly Leu Ser Thr 
145                 150                 155                 160 


Glu Leu Glu Phe Leu Thr Lys Gly Arg Tyr Arg Thr Gln Thr Ile Asp 
                165                 170                 175     


Gly Lys Arg Ser Thr Lys Leu Asn Pro Asn Phe Ile Tyr Ser Leu Gln 
            180                 185                 190         


Asp Lys Asn Glu Arg Leu Asn Lys Met Gly Leu Ile Phe Leu Ala Cys 
        195                 200                 205             


Gln Leu Ile Glu Lys Lys Tyr Ala Ser Met Leu Phe Asp Gln Gln Gly 
    210                 215                 220                 


Tyr Met Gly Arg Asp Ile Tyr Phe Asp Phe Thr Pro Ala Gln Cys Lys 
225                 230                 235                 240 


Tyr Ile Arg Glu Val Phe Ser Ala His Arg Ile Val Leu Pro Arg Gly 
                245                 250                 255     


Arg Met Asp Val Glu Arg Asn Glu Ile Thr Ile Ala Met Asp Met Phe 
            260                 265                 270         


Asn Glu Leu Gly Lys Cys Pro Lys Glu Leu Phe Glu Ile Ile Ser Lys 
        275                 280                 285             


Glu Glu Gln Lys Arg Phe Arg Thr Lys Ser Glu Thr Thr Gly Glu Glu 
    290                 295                 300                 


Val Leu Leu Met Arg His Ser Asp Arg Phe Ala Thr Leu Ala Leu Gln 
305                 310                 315                 320 


Tyr Ile Asp Asn Arg Lys Val Phe Glu Lys Ile Arg Phe Gln Leu Ser 
                325                 330                 335     


Leu Gly Lys Tyr Arg Tyr Lys Phe Tyr Asp Lys Thr Cys Val Asp Gly 
            340                 345                 350         


Asp Thr His Val Arg Ile Leu Gln Lys Glu Leu Asn Gly Phe Gly Arg 
        355                 360                 365             


Ile Asn Glu Ile Glu Leu Leu Lys Glu Glu Lys Trp Gly Gly Leu Ile 
    370                 375                 380                 


Arg Lys Phe Glu Asp Ala Lys Ile Asp Thr Ala Glu Thr Lys Pro Tyr 
385                 390                 395                 400 


Ile Thr Asp Gln Tyr Pro Gln Tyr Leu Phe Asn Gly Asn Arg Ile Gly 
                405                 410                 415     


Ile Tyr Phe Asn Ser Ala His Gly Lys Ala Met Arg Asn Gly Ala Tyr 
            420                 425                 430         


Ile Pro Asp Ile Glu Ser Gly Ala His Cys Ile Gln Pro Ile Cys Trp 
        435                 440                 445             


Ile Ser Asn Tyr Glu Leu Pro Ala Leu Ile Phe His His Ile Leu Thr 
    450                 455                 460                 


Lys Asp Glu Lys Lys Ser Leu Thr Glu Lys Ile Ile Ile Asp Cys Val 
465                 470                 475                 480 


Glu Arg Tyr Lys Lys Leu Phe Asn Asp Ile Ala Glu Gly Lys Val Ala 
                485                 490                 495     


Arg Thr Gly Asn Ala Thr Ser Asp Phe Glu Met Ile Ser Lys Glu Tyr 
            500                 505                 510         


Gly Ile Glu Lys Ser Asp Ile Pro Arg Glu Leu Gln Asp Tyr Phe Asn 
        515                 520                 525             


Gly Thr Glu Arg Asp Gly Ile Glu Gln Tyr Ala Lys Ala Gln Ile Arg 
    530                 535                 540                 


Glu Met Ile Glu Glu Asn Arg Ile Arg Leu Glu Gln Phe Asn Ser Lys 
545                 550                 555                 560 


Leu Lys Lys Ile Glu Asp Gly Glu Val Lys Tyr Gly Lys Arg Asp Tyr 
                565                 570                 575     


Thr Glu Ile Arg Thr Gly Glu Leu Ala Gln Tyr Leu Ala Lys Asp Ile 
            580                 585                 590         


Val Met Phe Met Pro Lys Ala Lys Tyr Lys Pro Thr Ser Lys Asn Tyr 
        595                 600                 605             


Asn Val Met Gln Ala Leu Leu Ala Thr Phe Asn Gly Ser Glu Ser Gly 
    610                 615                 620                 


Ser Thr Leu Asp Glu Val Asp Asp Met Phe Asp Asn Ile Lys Ala Cys 
625                 630                 635                 640 


Tyr Trp Lys Asn Glu Ser Asp Asn His Pro Phe Leu Glu Tyr Val Leu 
                645                 650                 655     


Gly Glu Glu Pro Lys Asp Ile Ile Ala Phe Tyr Lys Ile Tyr Leu Glu 
            660                 665                 670         


Leu Arg Gly Glu Tyr Leu Asp Lys Cys Ile Lys Lys Met Asp Leu Ala 
        675                 680                 685             


Thr Ile Pro Phe Ile His Thr Glu Arg Lys Arg Trp Glu Lys Arg Asp 
    690                 695                 700                 


Glu Lys Phe Phe Lys Glu Leu Ala Gln Arg Tyr Ala Thr Gln Pro Ile 
705                 710                 715                 720 


Glu Leu Pro Arg Gly Leu Tyr Asp Arg Ala Ile Lys Glu Tyr Leu Lys 
                725                 730                 735     


Ser Lys Ser Ile Leu Glu Asp Val Ile Ala Gln Glu Gln Cys Asn Val 
            740                 745                 750         


Thr Tyr Leu Ile Ala Arg Tyr Met Gln Asp Val Leu Lys Asp Asp Ser 
        755                 760                 765             


Gln Gln Phe Tyr Ser Leu Pro Arg His Tyr Ser Cys Leu Ser Glu Lys 
    770                 775                 780                 


Asp Lys Tyr Leu Ser Leu Thr Glu Arg Glu Ala Ile Ala Lys Ser Asp 
785                 790                 795                 800 


Ala Leu Asn Ser Phe Lys Lys Arg Glu Arg Glu Lys Glu Asn Glu Asn 
                805                 810                 815     


Arg Arg Gly Asn Arg Arg Tyr Asn Lys Gly Glu Asn Lys Asn Thr Ile 
            820                 825                 830         


Lys Asp Arg Asp Thr Glu Glu Lys Phe Asn Ser Leu Tyr Arg Lys Met 
        835                 840                 845             


Asp Asn Asn Glu Arg Ile Leu Arg Arg Tyr Lys Val Gln Asp Met Leu 
    850                 855                 860                 


Leu Tyr Leu Leu Ala Cys Asp Ile Ile Lys Gly Ile Met Arg Glu Asp 
865                 870                 875                 880 


Phe Gly Tyr Lys Leu Ser Met Ile Thr Asp Gly Lys Asn Ser Asn Phe 
                885                 890                 895     


Phe Asp Tyr Lys Met Pro Glu Phe Lys Thr Thr Ile Thr Leu Lys Glu 
            900                 905                 910         


Gly Lys Lys Phe Thr Ile Lys Gln Gln Tyr Leu Lys Ile Lys Asn Tyr 
        915                 920                 925             


Gly Asp Phe Leu Lys Phe Ile Phe Asp Leu Arg Ile Asp Ser Leu Leu 
    930                 935                 940                 


Ser Asn Gly Thr Lys Val Glu Ile Asp Arg Asn Ile Leu Glu Asp Glu 
945                 950                 955                 960 


Leu Ser Asn Tyr Asp Gly Ser Arg Pro Lys Val Phe Glu Thr Leu Leu 
                965                 970                 975     


Met Ile Glu Lys Ile Val Val Glu Lys His Lys Glu Leu Lys Asp Leu 
            980                 985                 990         


Glu His Ile Thr Phe Gly Asp Val  Leu Asn Val Ile Lys  Met Glu Glu 
        995                 1000                 1005             


Gly Glu  Lys Lys Ile Leu Arg  Leu Ile Arg Asn Ala  Phe Ser His 
    1010                 1015                 1020             


Asn Tyr  Tyr Pro Thr Ile Lys  Asp Val Asn Tyr Asp  Asn Met Pro 
    1025                 1030                 1035             


Glu Val  Ala Glu Ser Leu Lys  Asp Ile Leu Glu Lys  Glu Ser Lys 
    1040                 1045                 1050             


Lys Leu  Thr Asn 
    1055         


<210>  1419
<211>  1047
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1419

Met Glu Glu Gln Phe Leu Gln Lys Glu Arg Asn Met Gly Asp Asn Pro 
1               5                   10                  15      


Tyr Tyr Phe Cys His Phe Ile Asn Met Ala His His Asn Val Asn Leu 
            20                  25                  30          


Ile Leu Glu Glu Ile Tyr Asn Ser Val Tyr Glu Lys Tyr Thr Gln Asp 
        35                  40                  45              


Lys Glu Glu Asn Ile Lys Ala Ile Cys Asn Ser Met Ile Ser Lys Ser 
    50                  55                  60                  


Arg Lys Asn Pro Asp Glu Lys Ala Lys Met Met Asn Met Cys Ile Arg 
65                  70                  75                  80  


His Phe Pro Phe Leu Asp Tyr Tyr Lys Glu Lys Asp Gln Asn Ser Asp 
                85                  90                  95      


Val Leu Thr Ile Leu Leu Asn Gln Phe Leu Val Pro Leu His Gly Leu 
            100                 105                 110         


Arg Asn Gln Phe Ser His Tyr Lys His Pro Gln Glu Ala Tyr Cys Ile 
        115                 120                 125             


Ser Gly Phe Asp Leu Leu Phe Glu Gln Ala Lys Thr Gly Ala Gln Met 
    130                 135                 140                 


Arg Met Lys Tyr Ser Asp Glu Asp Ile Ser Lys Val Lys Ser Lys Val 
145                 150                 155                 160 


Val Asn His Asp Ser Ile Leu Thr Glu Arg Gly Ile Leu Phe Phe Ile 
                165                 170                 175     


Cys Leu Phe Leu Asp Lys Arg Asn Ile Tyr Leu Phe Leu Ser Lys Ile 
            180                 185                 190         


Lys Gly Phe Arg Asp Arg Arg Pro Asp Glu Lys Tyr Lys Ser Ala Thr 
        195                 200                 205             


Leu Glu Val Phe Ser Gln Tyr Tyr Cys His Val Pro Tyr Arg Lys Leu 
    210                 215                 220                 


Asp Ser Ser Asp Val Ala Leu Asp Met Leu Asn Glu Leu Asn Arg Cys 
225                 230                 235                 240 


Pro Lys Ala Leu Tyr Asp Val Leu Ser Asp Glu Asp Arg Glu Arg Phe 
                245                 250                 255     


Ile Val Asp Asn Val Glu Asn Ala Asp Asn Arg Asp Glu Ile Ser Asp 
            260                 265                 270         


Glu Asp Asp Glu Glu Met Pro Arg Ser Val Met Lys Arg Ser Asp Asp 
        275                 280                 285             


Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Glu Lys Gln Asn Asn Leu 
    290                 295                 300                 


Asp Glu Ile Ser Phe His Leu Tyr Leu Gly Arg Lys Glu Ala Lys Pro 
305                 310                 315                 320 


Ala His Glu Lys Val Ile Asn Gly Glu Met Arg Thr His Lys Ile Leu 
                325                 330                 335     


Lys Asp Ile His Val Phe Gly Arg Leu Glu Asn Tyr Arg Asn Glu Glu 
            340                 345                 350         


Ile Cys Asn Ala Ile Lys Asn Arg Glu Asp Ile Glu Phe Tyr Ala Pro 
        355                 360                 365             


Ser Tyr Arg Ile Val Glu Asn Arg Ile Gly Leu Leu Leu Arg Arg Gln 
    370                 375                 380                 


Asn Asp Phe Thr Leu Glu Glu Ala Asn Glu Glu Lys Ile Phe Glu Gly 
385                 390                 395                 400 


Asn Leu Cys Pro Asp Val Ile Leu Ser Thr His Glu Leu Gly Ala Leu 
                405                 410                 415     


Phe Phe Tyr Asn Tyr Leu His Lys Lys Gly Trp Ile Glu Ser Ala Pro 
            420                 425                 430         


Tyr Leu Tyr Ile Arg Asn Phe Ile Ser Asp Phe Lys Arg Phe Ile Glu 
        435                 440                 445             


Asp Ile Lys Asn Gly Lys Leu Thr Pro Val Glu Ser Glu Asp Asp Phe 
    450                 455                 460                 


Tyr Leu Ile Lys Lys Lys Lys Arg Asp Glu Thr Lys Asp Asn Asp Lys 
465                 470                 475                 480 


Lys Ser Ile Ala Val Gln Glu Arg Arg Arg Glu Lys Leu Lys Glu Lys 
                485                 490                 495     


Leu Lys Gly Tyr His Leu Glu Pro Asp Trp Ile Pro Asp Ala Cys Arg 
            500                 505                 510         


Glu Tyr Met Leu Gly Tyr Lys Ala Asp Gln Lys Asp Tyr Tyr Thr Lys 
        515                 520                 525             


Gln Arg Phe Cys Ser Met Lys Lys Glu Thr Asp Ser Arg Ile Lys Gln 
    530                 535                 540                 


Ile Glu Ala Ile Arg Lys Arg Glu Asp Asn Ser Ile Ile Arg Gln Thr 
545                 550                 555                 560 


Arg Val Gly Glu Ile Ala Gln Glu Leu Ala Arg Asp Ile Val Phe Leu 
                565                 570                 575     


Ile Pro Pro Tyr Lys Asn Glu Lys Gly Ala Asp Thr Lys Ile Asn Asn 
            580                 585                 590         


Met Glu Phe Asp Val Leu Gln Lys Met Leu Ala Tyr Phe Pro Leu Asn 
        595                 600                 605             


Lys Lys Asp Ile Tyr Pro Phe Leu Lys Asn Ile Arg Asn Trp Asp Lys 
    610                 615                 620                 


His Pro Phe Leu Lys Tyr Thr Leu His Thr Glu His Gln Ser Leu Leu 
625                 630                 635                 640 


Asp Phe Tyr Gln Asp Tyr Leu Asn Cys Lys Lys Arg Trp Ile Ser Lys 
                645                 650                 655     


Asn Ile Arg Tyr Asp Lys Gln Lys Gly Asn Tyr Leu Val Asp Ala Asn 
            660                 665                 670         


Lys Thr Glu Gln Glu Cys Arg Tyr Phe Leu Lys Thr Asp Lys Leu Arg 
        675                 680                 685             


Thr Ala Lys Glu Lys Glu Tyr Phe Glu Glu Pro Asp Lys Pro Val Tyr 
    690                 695                 700                 


Leu Pro Thr Gly Phe Phe Val Asp Pro Ile Val Glu Ala Met Arg Lys 
705                 710                 715                 720 


Asn Gly Tyr Glu Leu Lys Glu Asn Ser Asn Ile Val Gly Cys Leu Lys 
                725                 730                 735     


Ile Tyr Phe Val Ser Lys Ile Gln Pro Met Tyr Asp Leu Ser Arg Tyr 
            740                 745                 750         


Tyr Thr Tyr Tyr Asp Gly Lys Glu Glu Arg Ser Met Gln Leu Asp Asp 
        755                 760                 765             


Leu Lys Val Phe Ile Lys Glu Lys Phe Gly Asn Lys Arg Thr Asp Asp 
    770                 775                 780                 


Asn Thr Ile Arg Phe Leu Lys Lys Ala Ala Lys Arg Ile Arg Glu Asn 
785                 790                 795                 800 


Glu Ser Glu Ile Leu Val Arg Gln Met Asp Asp Cys Ala Leu Phe Leu 
                805                 810                 815     


Met Val Asn Asp Leu Leu Glu Gly Gly Lys Phe Asn Asp Glu Asp Ile 
            820                 825                 830         


Glu Asn Ile Gly Tyr Asn Lys His His Asn Leu Leu Asp His Glu Tyr 
        835                 840                 845             


Asp Met Cys Glu Thr Ile Tyr Gly Arg Lys Val Thr Ala Arg Leu Pro 
    850                 855                 860                 


Ile Lys Arg Tyr Gly Glu Phe Arg Arg Phe Met Lys Asp Arg Arg Leu 
865                 870                 875                 880 


Gln Asn Leu Val Lys Tyr Tyr Pro Gly Asp His Glu Thr Pro Ile Pro 
                885                 890                 895     


Ser Gly Ile Pro Glu Ser Gly Lys Ala Met Glu Lys Asn Lys Lys Tyr 
            900                 905                 910         


Thr Tyr Ser Asn Leu Cys Asp Glu Leu Glu Ile Tyr Asp Lys Glu Arg 
        915                 920                 925             


Asp Asn Val Leu Asn Leu Ile Tyr Glu Val Asp Lys Ile Leu Val Asp 
    930                 935                 940                 


His Phe Pro Asp Lys Ile Met Lys Glu Glu Asp Gly Tyr Tyr Glu His 
945                 950                 955                 960 


Tyr His Cys Leu Asp Phe Ala Lys Lys Glu Phe Gly Leu Glu Ser Asp 
                965                 970                 975     


Val Glu Leu Leu Ser Gln Asp Asn Phe Lys Asp Leu Arg Asn Ala Leu 
            980                 985                 990         


Tyr His Asn Gln Ile Pro Tyr Asn  Asp Trp Val Ala Asp  Lys Ile Ser 
        995                 1000                 1005             


Lys Asp  Thr Glu Glu Pro Met  Tyr Val Arg Arg Ile  Phe Ser Phe 
    1010                 1015                 1020             


Ile Arg  Thr Val Tyr Ser Arg  Leu Leu Asp Gln Ile  Lys Ile Lys 
    1025                 1030                 1035             


Ile Glu  Lys Asp Glu Tyr Lys  Cys Lys 
    1040                 1045         


<210>  1420
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1420

Met Glu Thr Lys Gln Gln Val Gly Lys Gly Ile Ser Tyr Asp His Arg 
1               5                   10                  15      


Arg Pro Asp Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asp Gly Val Ile Gln Glu Phe Ala Met Arg Leu Asn Arg 
        35                  40                  45              


Glu Tyr Asp Pro Glu Asn Lys Asn Gln Ser Leu Phe Ser Tyr Phe Asn 
    50                  55                  60                  


Ile Asn Ala Ser Phe Thr Asp Trp Glu Arg Gly Val Asn Ile Leu Lys 
65                  70                  75                  80  


Glu Tyr Trp Pro Met Met Glu Phe Ile Asp Arg Pro Ala Thr Asp Lys 
                85                  90                  95      


Gln Phe Glu Ala Glu Lys Pro Glu Asn Arg Glu Ala Ala Lys Arg Lys 
            100                 105                 110         


Tyr Phe Leu Ala Thr Leu Gly Ala Leu Leu Thr Ser Ile Lys Asp Leu 
        115                 120                 125             


Arg His Tyr Tyr Thr His Tyr Tyr His Pro Pro Val His Leu Asn Asp 
    130                 135                 140                 


Asp Leu Phe Leu Phe Leu Asp His Ala Leu Leu Tyr Thr Ala Phe Asp 
145                 150                 155                 160 


Val Lys Lys Thr Lys Met Lys Asp Asp Lys Thr Arg Gln Leu Leu Asn 
                165                 170                 175     


Gln Asn Leu Ser Leu Glu Leu Glu Lys Leu Lys Lys Leu Lys Val Glu 
            180                 185                 190         


Glu Leu Lys Lys Lys Lys Glu Lys Gly Ile Lys Val Asn Leu Gln Asp 
        195                 200                 205             


Glu Lys Gly Ile Leu Asn Ala Ile Tyr Asn Asp Ala Phe Ala His Ile 
    210                 215                 220                 


Ile Thr Lys Glu Lys Asp Ser Asp Lys Asp Lys Leu Glu Thr Arg Tyr 
225                 230                 235                 240 


Lys Ser Ile Leu Pro Gln Asp Glu Ala Ala Glu Thr Gly Ile Asn Ile 
                245                 250                 255     


Ser Ile Ser Gly Leu Ile Phe Leu Leu Ser Leu Phe Leu Ser Arg Lys 
            260                 265                 270         


Glu Ile Glu Gln Leu Lys Ser Asn Ile Glu Gly Tyr Lys Gly Lys Val 
        275                 280                 285             


Leu Asn Ile Glu Thr Glu Val Asp Arg Lys His Asn Ser Leu Lys Tyr 
    290                 295                 300                 


Met Ala Thr His Trp Val Phe Ser Ile Leu Ala Phe Lys Gly Leu Lys 
305                 310                 315                 320 


Gln Arg Leu Thr Asn Ser Phe Glu Lys Glu Ser Leu Leu Ile Gln Met 
                325                 330                 335     


Met Asp Glu Leu Asn Lys Val Pro Asp Glu Leu Tyr Gln Thr Leu Ser 
            340                 345                 350         


Glu Thr Ala Lys Lys Glu Phe Leu Glu Asp Ile Asn Glu Tyr Val Ser 
        355                 360                 365             


Glu Gly Asp Asp Asn Glu Lys Ala Thr Tyr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Ser Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gln Phe Pro Thr Leu Lys Phe Gln Ile Phe Val Gly 
                405                 410                 415     


Gln Tyr Leu His Asp Asn Arg Pro Lys Thr Leu Ala Ser Asn Gly Met 
            420                 425                 430         


Thr Ala Gln Arg Met Ile Lys Glu Lys Ile Asn Leu Phe Gly Asn Leu 
        435                 440                 445             


Ser Glu Val Thr Lys His Lys Ser Asp Phe Phe Glu Lys Glu Ser Ala 
    450                 455                 460                 


Ala Gln Gly Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Trp Ala Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Val Tyr Ile Asp Met Ile Gly Lys Glu Gly Lys Ala 
                485                 490                 495     


Lys Glu Ile Gln Val Gln Ile Asn Lys Tyr Arg Lys Gln Leu Asn Pro 
            500                 505                 510         


Ala Pro Gln Arg Asp Lys Arg Ile Ser Lys Lys Glu Ile Ile Glu Gln 
        515                 520                 525             


Leu Tyr Lys Glu Lys Val Val Tyr Gly Asp Pro Thr Leu Met Leu Ser 
    530                 535                 540                 


Ala Asn Glu Leu Met Ala Leu Leu Tyr Glu Leu Ile Val Asn Gly Lys 
545                 550                 555                 560 


Ser Gly Ala Glu Leu Glu Asn Lys Ile Val Glu Gln Ile Ile Ala Arg 
                565                 570                 575     


Tyr Glu Gln Ile Glu Ala Tyr Asp Pro Thr Thr Gln Gln Leu Pro Thr 
            580                 585                 590         


Asn Gln Met Pro His Lys Leu Gln Lys Ser Arg Lys Asp Ser Lys Val 
        595                 600                 605             


Thr Asp Thr Asp Lys Leu Leu Lys Thr Ile Asp Lys Glu Ile Asp Glu 
    610                 615                 620                 


Gly Asn Lys Lys Leu Glu Leu Ile Ala Cys His Arg Lys Glu Trp Glu 
625                 630                 635                 640 


Glu Ala Glu Gln Arg Lys Lys Ser Gly Lys Arg Asn Asn Pro Gly Thr 
                645                 650                 655     


Lys Ser Arg Lys His Leu Phe Tyr Ala Ser Glu Met Gly Glu Glu Ala 
            660                 665                 670         


Thr Trp Ile Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Pro Ala Arg 
        675                 680                 685             


Ala Glu Trp Lys Gly Thr His His Ser Glu Leu Gln Arg Leu Leu Ala 
    690                 695                 700                 


Phe Tyr Ser Thr Gln Arg Leu Glu Ala Trp Gln Leu Val Glu Ser Val 
705                 710                 715                 720 


Trp Thr Ala Asn Thr His Ser Phe Trp Glu Glu Asn Phe Lys Glu Ala 
                725                 730                 735     


Phe Tyr Lys Pro Glu Phe Glu Asn Phe Tyr Gly Ala Tyr Ile Glu Ile 
            740                 745                 750         


Arg Thr Lys Ile Leu Thr Thr Cys Arg Ser Ile Leu Glu Asn Asn Pro 
        755                 760                 765             


Glu Ala Thr Met Asn Asn Asp Thr Glu Lys Glu Trp Asp Lys Val Phe 
    770                 775                 780                 


Thr Leu Phe Asp Lys Arg Leu Tyr Arg Thr Ser Thr Thr Asp Glu Gln 
785                 790                 795                 800 


Lys Lys Gln Leu Leu Thr Lys Pro Phe Ala Phe Pro Arg Gly Leu Phe 
                805                 810                 815     


Asp Asp Lys Pro Thr Phe Leu Pro Gly Ser Lys Pro Asn Glu Asn Pro 
            820                 825                 830         


Glu Arg Phe Ala Ala Trp Tyr Ser Tyr Gly Tyr Thr Tyr Ser Gly Lys 
        835                 840                 845             


Phe Gln Ser Phe Tyr Asp Met Pro Arg Asn Tyr Ser Asp Trp Tyr Lys 
    850                 855                 860                 


Lys Leu Lys Glu Asp Gly Lys Leu Pro Arg Leu Asp Lys Lys Thr Glu 
865                 870                 875                 880 


Gln Glu Lys Ile Leu Arg Phe Arg Met Asp Cys Asp Leu Asn Ile Lys 
                885                 890                 895     


His Ile Arg Phe Gln Asp Ile Tyr Val Lys Leu Met Val Asp Ser Leu 
            900                 905                 910         


Tyr Lys Ala Val Phe Gly Gln Gln Pro Glu Phe Asp Leu Ser His Leu 
        915                 920                 925             


Tyr Asp Thr Arg Ser Glu Arg Tyr Glu Asn Asn Thr Ile Ala Gln Arg 
    930                 935                 940                 


Gln Lys Ser Arg Gln Glu Gly Asp Asn Ser Asp Asn Ala Ile Asn Glu 
945                 950                 955                 960 


Asn Tyr Val Trp Asn Lys Thr Phe Ala Ile Ser Leu Tyr Asn Gly Arg 
                965                 970                 975     


Ile Thr Glu Ser Gln Val Lys Leu Lys Asp Val Gly Lys Phe Arg Arg 
            980                 985                 990         


Phe Ala Thr Asp Pro Arg Val Gln  Thr Leu Ile Ser Tyr  Asp Asp Thr 
        995                 1000                 1005             


Arg Thr  Trp Thr Lys Leu Glu  Ile Glu Asn Glu Leu  Asp Asn Lys 
    1010                 1015                 1020             


Ala Asp  Ala Tyr Glu Pro Ile  Arg Arg Thr Gln Ser  Leu Lys Ala 
    1025                 1030                 1035             


Ile Gln  Gln Leu Glu Lys Asn  Ile Leu Lys Lys Asn  Gly Phe Asn 
    1040                 1045                 1050             


Gly Lys  Gln His Pro Glu Glu  Leu Lys His Asn Gly  Asn Pro Asn 
    1055                 1060                 1065             


Phe Arg  Lys Tyr Ile Ala Asn  Gly Leu Leu Lys His  Arg Thr Asp 
    1070                 1075                 1080             


Ile Arg  Gln Glu Glu Leu Ala  Leu Ile Ser Asp Thr  Glu Phe Gln 
    1085                 1090                 1095             


Glu Ile  Gly Leu Glu Arg Ile  Arg Gln Thr Asn Pro  Leu Ile Gln 
    1100                 1105                 1110             


Lys Ala  Tyr Leu Leu Ile Leu  Leu Arg Asn Lys Phe  Gly His Asn 
    1115                 1120                 1125             


Gln Leu  Pro Asp Gln Glu His  Phe Arg Leu Met Arg  Ser Ile Tyr 
    1130                 1135                 1140             


Pro Tyr  Asn Gln Gln Glu Ser  Tyr Ser Ala Tyr Phe  Asn His Val 
    1145                 1150                 1155             


Ile Thr  Gln Ile Ile Glu Glu  Leu Asn Thr 
    1160                 1165             


<210>  1421
<211>  1094
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1421

Met Glu Ala Asn Glu Gln Asn Gln Glu Asn Arg Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Asn Asn His Ile Ala Ala Asp Phe Gly Gln Ala Val 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ser Gly Phe Leu Cys Asn Lys Glu 
    50                  55                  60                  


Ile Lys Lys Leu Asn Trp Asn His Ile Tyr Ala Lys Thr Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ile Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Val Asn Ser Asp Lys Glu Gly Lys Asp Phe Ala Ala Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Ser Glu Leu Gln Asp Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Glu Asn Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Ala Glu Leu Thr Asp Met Leu Thr Ile Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Thr Asp Ala Asp Tyr 
                165                 170                 175     


Glu Leu Val Glu Thr Lys Gln Val Val Thr Thr Gly Asn Ile Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Met Phe Leu Glu Arg Glu His 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asn Leu Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Gly 
            260                 265                 270         


Val Ile Thr Asp Glu Glu Lys Met Gln Phe Arg Pro Glu Leu Asp Glu 
        275                 280                 285             


Leu Asp Ile Glu Lys Leu Ile Ala Asn Ser Thr Asn Asp Asp Glu Arg 
    290                 295                 300                 


Glu Arg Ile Leu Asp Glu Ile Gly Tyr Glu Glu Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg Tyr Asn Asn Arg Phe Pro Tyr Phe Ala Met Arg 
                325                 330                 335     


Phe Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Arg Tyr Thr Lys Gln Leu Ala Gly Glu 
        355                 360                 365             


Gln Thr Glu Arg Val Val Gln Glu Asn Val Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asp Pro Glu Leu Ile Gln Gln Lys Ile Asp Asn Gln 
385                 390                 395                 400 


Gln Arg Thr Asp Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Ile Ala Ile Leu Ile 
            420                 425                 430         


Pro Lys Ser Lys Pro Glu Ser Lys Val Gly Asn Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Asp Tyr Leu Gln Lys Gly Lys Ala Glu Glu Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Ile Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Leu Lys Leu Pro Ala Asn Trp Asn Glu Phe Ala Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asp Ala Ala Met Glu Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Asp Val Leu Ile Thr Tyr Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Asp Val Glu Asp Asn Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Leu Glu Lys His Lys Leu 
            580                 585                 590         


Asp Lys Ser Val Lys Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Met Val Ser Lys Glu Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Ala Asp Thr Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Val Leu Glu Gly Asp Gly His Pro Phe Leu Thr Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Glu Leu Tyr Met Asn 
        675                 680                 685             


Ala Lys Val Gln Tyr Leu Ile Gln Phe Tyr Lys Pro Ser Lys Asp Lys 
    690                 695                 700                 


Val Asp Lys Arg Gly Arg Pro Thr Thr Glu Val Lys Leu Pro Pro Leu 
705                 710                 715                 720 


Asp Lys Arg Ser Asn Ile Pro Phe Thr Ile Arg Gln Trp Asp Glu Lys 
                725                 730                 735     


Glu Lys Tyr Asn Leu Asn Ala Trp Leu Arg Asn Val Thr Val Gly Lys 
            740                 745                 750         


Asn Thr Lys Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe 
        755                 760                 765             


Asp Glu Thr Leu Cys Asp Leu Leu Ser Gln Gln Leu Asp Ala Arg Thr 
    770                 775                 780                 


Val Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Leu Trp 
785                 790                 795                 800 


Trp Lys Thr Arg Asp Asp Ala Thr Gln Asp Phe Tyr Gln Ser Glu Arg 
                805                 810                 815     


Glu Tyr Asp Ile Tyr Glu Glu Lys Val Glu Phe Lys Ile Asp Ser Ser 
            820                 825                 830         


Gly His Phe Ala Asp Tyr Tyr Lys Lys Ala Leu Ser Lys Ala Tyr Asn 
        835                 840                 845             


Arg Leu Lys Ala Glu Arg Glu Ile Ala Arg Arg Thr Asn Lys Arg Leu 
    850                 855                 860                 


Pro Pro Ile Glu His Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile 
865                 870                 875                 880 


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
                885                 890                 895     


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asp Ser Gly Asn Leu Lys 
            900                 905                 910         


Leu Ser Thr Ile Lys Thr Ser Leu Asn Asn Thr Thr Gln Ile Lys Gln 
        915                 920                 925             


Lys Ile Leu Asn Lys Thr Ile Val Ala Glu Arg Lys Gln Lys Asn Tyr 
    930                 935                 940                 


Thr Glu Leu Arg Lys Tyr Val His Asp Arg Arg Leu Pro Asn Leu Phe 
945                 950                 955                 960 


Glu Tyr Val Glu Ala Asp Glu Ile Leu Leu Glu Trp Leu Leu Asp Glu 
                965                 970                 975     


Leu Met Ala Tyr Asn Ala Ala Lys Gln Gln Val Phe Asp Thr Ile Phe 
            980                 985                 990         


Met Leu Glu Lys Arg Ile Ile Glu  Thr Asp Pro Gln Glu  Leu Lys Ser 
        995                 1000                 1005             


Leu Phe  Thr Asn Glu Lys Gly  Gln Val Gln Thr Gly  Asn Ile Gln 
    1010                 1015                 1020             


His Lys  Pro Tyr Val Gln Trp  Leu Lys Asn Lys Gly  Leu Ile Asn 
    1025                 1030                 1035             


His Asn  Glu Lys Leu Phe Ile  Asn Met Val Arg Asn  Cys Phe Ser 
    1040                 1045                 1050             


His Asn  Gln Phe Pro Gln Arg  Glu Thr Met Glu Leu  Leu Ile Ser 
    1055                 1060                 1065             


Glu Trp  Gly Ala Gly Lys Ile  Ala Thr Gln Ile Leu  Thr Val Tyr 
    1070                 1075                 1080             


Asn Gln  Leu Ile Thr Asn Ile  Ile Asn Lys Ile 
    1085                 1090                 


<210>  1422
<211>  1094
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1422

Met Glu Ala Asn Glu Gln Asn Gln Glu Asn Arg Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Asn Asn His Ile Ala Ala Asp Phe Gly Gln Ala Val 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ser Gly Phe Leu Cys Asn Lys Glu 
    50                  55                  60                  


Ile Lys Lys Leu Asn Trp Asn His Ile Tyr Ala Lys Thr Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ile Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Val Asn Ser Asp Lys Glu Gly Lys Asp Phe Ala Ala Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Ser Glu Leu Gln Asp Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Glu Asn Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Ala Glu Leu Thr Asp Met Leu Thr Ile Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Thr Asp Ala Asp Tyr 
                165                 170                 175     


Glu Leu Val Glu Thr Lys Gln Val Val Thr Thr Gly Asn Ile Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Met Phe Leu Glu Arg Glu His 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asn Leu Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Gly 
            260                 265                 270         


Val Ile Thr Asp Glu Glu Lys Met Gln Phe Arg Pro Glu Leu Asp Glu 
        275                 280                 285             


Leu Asp Ile Glu Lys Leu Ile Ala Asn Ser Thr Asn Asp Asp Glu Arg 
    290                 295                 300                 


Glu Arg Ile Leu Asp Glu Ile Gly Tyr Glu Glu Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg Tyr Asn Asn Arg Phe Pro Tyr Phe Ala Met Arg 
                325                 330                 335     


Phe Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Arg Tyr Thr Lys Gln Leu Ala Gly Glu 
        355                 360                 365             


Gln Thr Glu Arg Val Val Gln Glu Asn Val Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asp Pro Glu Leu Ile Gln Gln Lys Ile Asp Asn Gln 
385                 390                 395                 400 


Gln Arg Thr Asp Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Ile Ala Ile Leu Ile 
            420                 425                 430         


Pro Lys Ser Lys Pro Glu Ser Lys Val Gly Asn Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Asp Tyr Leu Gln Lys Gly Lys Ala Glu Glu Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Ile Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Leu Lys Leu Pro Ala Asn Trp Asn Glu Phe Ala Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asp Ala Ala Met Glu Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Asp Val Leu Ile Thr Tyr Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Asp Val Glu Asp Asn Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Leu Glu Lys His Lys Leu 
            580                 585                 590         


Asp Lys Ser Val Lys Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Met Val Ser Lys Glu Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Ala Asp Thr Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Val Leu Glu Gly Asp Gly His Pro Phe Leu Thr Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Glu Leu Tyr Met Asn 
        675                 680                 685             


Ala Lys Val Gln Tyr Leu Ile Gln Phe Tyr Lys Pro Ser Lys Asp Lys 
    690                 695                 700                 


Val Asp Lys Arg Gly Arg Pro Thr Thr Glu Val Lys Leu Pro Pro Leu 
705                 710                 715                 720 


Asp Lys Arg Ser Asn Ile Pro Phe Thr Ile Arg Gln Trp Asp Glu Lys 
                725                 730                 735     


Glu Lys Tyr Asn Leu Asn Ala Trp Leu Arg Asn Val Thr Val Gly Lys 
            740                 745                 750         


Asn Thr Lys Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe 
        755                 760                 765             


Asp Glu Thr Leu Cys Asp Leu Leu Ser Gln Gln Leu Asp Ala Arg Thr 
    770                 775                 780                 


Val Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Leu Trp 
785                 790                 795                 800 


Trp Lys Thr Arg Asp Asp Ala Thr Gln Asp Phe Tyr Gln Ser Glu Arg 
                805                 810                 815     


Glu Tyr Asp Ile Tyr Glu Glu Lys Val Glu Phe Lys Ile Asp Ser Ser 
            820                 825                 830         


Gly His Phe Ala Asp Tyr Tyr Lys Lys Ala Leu Ser Lys Ala Tyr Asn 
        835                 840                 845             


Arg Leu Lys Ala Glu Arg Glu Ile Ala Arg Arg Thr Asn Lys Arg Leu 
    850                 855                 860                 


Pro Pro Ile Glu His Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile 
865                 870                 875                 880 


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
                885                 890                 895     


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asp Ser Gly Asn Leu Lys 
            900                 905                 910         


Leu Ser Thr Ile Lys Thr Ser Leu Asn Asn Thr Thr Gln Ile Lys Gln 
        915                 920                 925             


Lys Ile Leu Asn Lys Thr Ile Val Ala Glu Arg Lys Gln Lys Asn Tyr 
    930                 935                 940                 


Thr Glu Leu Arg Lys Tyr Val His Asp Arg Arg Leu Pro Asn Leu Phe 
945                 950                 955                 960 


Glu Tyr Val Glu Ala Asp Glu Ile Leu Leu Glu Trp Leu Leu Asp Glu 
                965                 970                 975     


Leu Met Ala Tyr Asn Ala Ala Lys Gln Gln Val Phe Asp Thr Ile Phe 
            980                 985                 990         


Met Leu Glu Lys Arg Ile Ile Glu  Thr Asp Pro Gln Glu  Leu Lys Ser 
        995                 1000                 1005             


Leu Phe  Thr Asn Glu Lys Gly  Gln Val Gln Thr Gly  Asn Ile Gln 
    1010                 1015                 1020             


His Lys  Pro Tyr Val Gln Trp  Leu Lys Asn Lys Gly  Leu Ile Asn 
    1025                 1030                 1035             


His Asn  Glu Lys Leu Phe Ile  Asn Met Val Arg Asn  Cys Phe Ser 
    1040                 1045                 1050             


His Asn  Gln Phe Pro Gln Arg  Glu Thr Met Glu Leu  Leu Ile Ser 
    1055                 1060                 1065             


Glu Trp  Gly Ala Gly Lys Ile  Ala Thr Gln Ile Leu  Thr Val Tyr 
    1070                 1075                 1080             


Asn Gln  Leu Ile Thr Asn Ile  Ile Asn Lys Ile 
    1085                 1090                 


<210>  1423
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1423

Met Glu Thr Lys Gln Gln Val Gly Lys Gly Ile Ser Tyr Asp His Arg 
1               5                   10                  15      


Arg Pro Asp Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asp Gly Val Ile Gln Glu Phe Ala Met Arg Leu Asn Arg 
        35                  40                  45              


Glu Tyr Asp Pro Glu Asn Lys Asn Gln Ser Leu Phe Ser Tyr Phe Asn 
    50                  55                  60                  


Ile Asn Ala Ser Phe Thr Asp Trp Glu Arg Gly Val Asn Ile Leu Lys 
65                  70                  75                  80  


Glu Tyr Trp Pro Met Met Glu Phe Ile Asp Arg Pro Ala Thr Asp Lys 
                85                  90                  95      


Gln Phe Glu Ala Glu Lys Pro Glu Asn Arg Glu Ala Ala Lys Arg Lys 
            100                 105                 110         


Tyr Phe Leu Ala Thr Leu Gly Ala Leu Leu Thr Ser Ile Lys Asp Leu 
        115                 120                 125             


Arg His Tyr Tyr Thr His Tyr Tyr His Pro Pro Val His Leu Asn Asp 
    130                 135                 140                 


Asp Leu Phe Leu Phe Leu Asp His Ala Leu Leu Tyr Thr Ala Phe Asp 
145                 150                 155                 160 


Val Lys Lys Thr Lys Met Lys Asp Asp Lys Thr Arg Gln Leu Leu Asn 
                165                 170                 175     


Gln Asn Leu Ser Leu Glu Leu Glu Lys Leu Lys Lys Leu Lys Val Glu 
            180                 185                 190         


Glu Leu Lys Lys Lys Lys Glu Lys Gly Ile Lys Val Asn Leu Gln Asp 
        195                 200                 205             


Glu Lys Gly Ile Leu Asn Ala Ile Tyr Asn Asp Ala Phe Ala His Ile 
    210                 215                 220                 


Ile Thr Lys Glu Lys Asp Ser Asp Lys Asp Lys Leu Glu Thr Arg Tyr 
225                 230                 235                 240 


Lys Ser Ile Leu Pro Gln Asp Glu Ala Ala Glu Thr Gly Ile Asn Ile 
                245                 250                 255     


Ser Ile Ser Gly Leu Ile Phe Leu Leu Ser Leu Phe Leu Ser Arg Lys 
            260                 265                 270         


Glu Ile Glu Gln Leu Lys Ser Asn Ile Glu Gly Tyr Lys Gly Lys Val 
        275                 280                 285             


Leu Asn Ile Glu Thr Glu Val Asp Arg Lys His Asn Ser Leu Lys Tyr 
    290                 295                 300                 


Met Ala Thr His Trp Val Phe Ser Ile Leu Ala Phe Lys Gly Leu Lys 
305                 310                 315                 320 


Gln Arg Leu Thr Asn Ser Phe Glu Lys Glu Ser Leu Leu Ile Gln Met 
                325                 330                 335     


Met Asp Glu Leu Asn Lys Val Pro Asp Glu Leu Tyr Gln Thr Leu Ser 
            340                 345                 350         


Glu Thr Ala Lys Lys Glu Phe Leu Glu Asp Ile Asn Glu Tyr Val Ser 
        355                 360                 365             


Glu Gly Asp Asp Asn Glu Lys Ala Thr Tyr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Ser Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gln Phe Pro Thr Leu Lys Phe Gln Ile Phe Val Gly 
                405                 410                 415     


Gln Tyr Leu His Asp Asn Arg Pro Lys Thr Leu Ala Ser Asn Gly Met 
            420                 425                 430         


Thr Ala Gln Arg Met Ile Lys Glu Lys Ile Asn Leu Phe Gly Asn Leu 
        435                 440                 445             


Ser Glu Val Thr Lys His Lys Ser Asp Phe Phe Glu Lys Glu Ser Ala 
    450                 455                 460                 


Ala Gln Gly Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Trp Ala Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Val Tyr Ile Asp Met Ile Gly Lys Glu Gly Lys Ala 
                485                 490                 495     


Lys Glu Ile Gln Val Gln Ile Asn Lys Tyr Arg Lys Gln Leu Asn Pro 
            500                 505                 510         


Ala Pro Gln Arg Asp Lys Arg Ile Ser Lys Lys Glu Ile Ile Glu Gln 
        515                 520                 525             


Leu Tyr Lys Glu Lys Val Val Tyr Gly Asp Pro Thr Leu Met Leu Ser 
    530                 535                 540                 


Ala Asn Glu Leu Met Ala Leu Leu Tyr Glu Leu Ile Val Asn Gly Lys 
545                 550                 555                 560 


Ser Gly Ala Glu Leu Glu Asn Lys Ile Val Glu Gln Ile Ile Ala Arg 
                565                 570                 575     


Tyr Glu Gln Ile Glu Ala Tyr Asp Pro Thr Thr Gln Gln Leu Pro Thr 
            580                 585                 590         


Asn Gln Met Pro His Lys Leu Gln Lys Ser Arg Lys Asp Ser Lys Val 
        595                 600                 605             


Thr Asp Thr Asp Lys Leu Leu Lys Thr Ile Asp Lys Glu Ile Asp Glu 
    610                 615                 620                 


Gly Asn Lys Lys Leu Glu Leu Ile Ala Cys His Arg Lys Glu Trp Glu 
625                 630                 635                 640 


Glu Ala Glu Gln Arg Lys Lys Ser Gly Lys Arg Asn Asn Pro Gly Thr 
                645                 650                 655     


Lys Ser Arg Lys His Leu Phe Tyr Ala Ser Glu Met Gly Glu Glu Ala 
            660                 665                 670         


Thr Trp Ile Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Pro Ala Arg 
        675                 680                 685             


Ala Glu Trp Lys Gly Thr His His Ser Glu Leu Gln Arg Leu Leu Ala 
    690                 695                 700                 


Phe Tyr Ser Thr Gln Arg Leu Glu Ala Trp Gln Leu Val Glu Ser Val 
705                 710                 715                 720 


Trp Thr Ala Asn Thr His Ser Phe Trp Glu Glu Asn Phe Lys Glu Ala 
                725                 730                 735     


Phe Tyr Lys Pro Glu Phe Glu Asn Phe Tyr Gly Ala Tyr Ile Glu Ile 
            740                 745                 750         


Arg Thr Lys Ile Leu Thr Thr Cys Arg Ser Ile Leu Glu Asn Asn Pro 
        755                 760                 765             


Glu Ala Thr Met Asn Asn Asp Thr Glu Lys Glu Trp Asp Lys Val Phe 
    770                 775                 780                 


Thr Leu Phe Asp Lys Arg Leu Tyr Arg Thr Ser Thr Thr Asp Glu Gln 
785                 790                 795                 800 


Lys Lys Gln Leu Leu Thr Lys Pro Phe Ala Phe Pro Arg Gly Leu Phe 
                805                 810                 815     


Asp Asp Lys Pro Thr Phe Leu Pro Gly Ser Lys Pro Asn Glu Asn Pro 
            820                 825                 830         


Glu Arg Phe Ala Ala Trp Tyr Ser Tyr Gly Tyr Thr Tyr Ser Gly Lys 
        835                 840                 845             


Phe Gln Ser Phe Tyr Asp Met Pro Arg Asn Tyr Ser Asp Trp Tyr Lys 
    850                 855                 860                 


Lys Leu Lys Glu Asp Gly Lys Leu Pro Arg Leu Asp Lys Lys Thr Glu 
865                 870                 875                 880 


Gln Glu Lys Ile Leu Arg Phe Arg Met Asp Cys Asp Leu Asn Ile Lys 
                885                 890                 895     


His Ile Arg Phe Gln Asp Ile Tyr Val Lys Leu Met Val Asp Ser Leu 
            900                 905                 910         


Tyr Lys Ala Val Phe Gly Gln Gln Pro Glu Phe Asp Leu Ser His Leu 
        915                 920                 925             


Tyr Asp Thr Arg Ser Glu Arg Tyr Glu Asn Asn Thr Ile Ala Gln Arg 
    930                 935                 940                 


Gln Lys Ser Arg Gln Glu Gly Asp Asn Ser Asp Asn Ala Ile Asn Glu 
945                 950                 955                 960 


Asn Tyr Val Trp Asn Lys Thr Phe Ala Ile Ser Leu Tyr Asn Gly Arg 
                965                 970                 975     


Ile Thr Glu Ser Gln Val Lys Leu Lys Asp Val Gly Lys Phe Arg Arg 
            980                 985                 990         


Phe Ala Thr Asp Pro Arg Val Gln  Thr Leu Ile Ser Tyr  Asp Asp Thr 
        995                 1000                 1005             


Arg Thr  Trp Thr Lys Leu Glu  Ile Glu Asn Glu Leu  Asp Asn Lys 
    1010                 1015                 1020             


Ala Asp  Ala Tyr Glu Pro Ile  Arg Arg Thr Gln Ser  Leu Lys Ala 
    1025                 1030                 1035             


Ile Gln  Gln Leu Glu Lys Asn  Ile Leu Lys Lys Asn  Gly Phe Asn 
    1040                 1045                 1050             


Gly Lys  Gln His Pro Glu Glu  Leu Lys His Asn Gly  Asn Pro Asn 
    1055                 1060                 1065             


Phe Arg  Lys Tyr Ile Ala Asn  Gly Leu Leu Lys His  Arg Thr Asp 
    1070                 1075                 1080             


Ile Arg  Gln Glu Glu Leu Ala  Leu Ile Ser Asp Thr  Glu Phe Gln 
    1085                 1090                 1095             


Glu Ile  Gly Leu Glu Arg Ile  Arg Gln Thr Asn Pro  Leu Ile Gln 
    1100                 1105                 1110             


Lys Ala  Tyr Leu Leu Ile Leu  Leu Arg Asn Lys Phe  Gly His Asn 
    1115                 1120                 1125             


Gln Leu  Pro Asp Gln Glu His  Phe Arg Leu Met Arg  Ser Ile Tyr 
    1130                 1135                 1140             


Pro Tyr  Asn Gln Gln Glu Ser  Tyr Ser Ala Tyr Phe  Asn His Val 
    1145                 1150                 1155             


Ile Thr  Gln Ile Ile Glu Glu  Leu Asn Thr 
    1160                 1165             


<210>  1424
<211>  1140
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1424

Met Glu Asn Asp Gln Gln Ile Leu Glu Asn Arg Arg Arg Thr Leu Ala 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Ser Asn His Leu Ala Thr Ser Phe Glu Gln Lys Ala 
        35                  40                  45              


Leu His Glu Glu Gly Gln Ile Pro Ala Ser Phe Leu Cys Asn Lys Ser 
    50                  55                  60                  


Ile Lys Lys Ile Asn Trp Asn His Val Tyr Ser Lys Ala Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Ile Phe Asp Ala Asp Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Arg Glu Thr Ser Asp Lys Glu Gly Lys Asp Phe Thr Ala Met Asn Glu 
            100                 105                 110         


Thr Leu Lys Leu Val Phe Asp Glu Leu Gln Ala Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Ala Asp Ser Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Val Glu Leu Ala Asp Phe Leu Thr Val Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Ala Asp Asp Asp Tyr 
                165                 170                 175     


Ala Val Val Glu Ser Lys Gln Ile Val Thr Pro Asp Asn Gln Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Ile Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Val Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Leu Ala Tyr Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asp Leu Arg Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Glu 
            260                 265                 270         


Val Ile Thr Glu Glu Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Glu Glu Glu Arg 
    290                 295                 300                 


Glu Lys Ile Leu Asp Glu Ile Asp Tyr Glu Asp Tyr Ile Glu Ser Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg His Ser Asn Arg Phe Pro Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Glu Lys Tyr Asn Lys Gln Phe Asp Gly Glu 
        355                 360                 365             


Ala Thr Glu Arg Lys Val Val Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asn Gln Glu Thr Val Glu Leu Lys Ile Asp Ser Ala 
385                 390                 395                 400 


Gln Arg Thr Asn Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Glu Ala Arg Leu Leu 
            420                 425                 430         


Thr Lys Ala Lys Pro Glu Ser Lys Val Ser Tyr Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Lys Ala Glu Glu Met Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Lys Val Asn Asp Ser Gln Leu Met Asn Met Gln Phe Ile Asp Glu 
                485                 490                 495     


Ile Lys Glu Gln Leu Pro Ala Asp Trp Asn Glu Phe Gly Lys Arg Ser 
            500                 505                 510         


Asp Ser Lys Lys Lys Lys Ala Tyr Thr Asn Ala Ala Arg Gln Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Lys Val Leu Ala Asn Tyr Gln Leu 
    530                 535                 540                 


Asn Asp Lys Gln Val Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Val 
545                 550                 555                 560 


Lys Glu Val Asp Asp Ser Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Met Glu Lys His Lys Val 
            580                 585                 590         


Asp Lys Ser Ala Arg Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Thr Asp Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Tyr 
625                 630                 635                 640 


Ala Asp Asn Glu Lys Lys Ala Thr Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Lys Asp Gly His Pro Phe Leu Ala Asn Ile Asn 
            660                 665                 670         


Leu Arg Gln Ile Arg Lys Thr Ser Gln Leu Tyr Glu Leu Tyr Leu Val 
        675                 680                 685             


Glu Lys Ala Asn Lys Gln Val Lys Lys Met Asn Pro Lys Thr Gln Arg 
    690                 695                 700                 


Thr Asn Asn Val Asp Glu Ser Trp Met Met Lys Ser Phe Tyr Ala Lys 
705                 710                 715                 720 


Glu Trp Asn Glu Glu Met Gly Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Thr Asn Ile Pro Phe Thr Ile Arg Gln Trp Glu Glu Lys 
            740                 745                 750         


Glu Lys His Asn Leu Gln Ala Trp Leu His Asn Ile Thr Lys Gly Lys 
        755                 760                 765             


Thr Ser Lys Asp Gly Lys Lys Ala Val Asp Leu Pro Thr Asn Leu Phe 
    770                 775                 780                 


Asp Asp Thr Leu Cys Glu Leu Leu Arg Glu Ala Leu Ile Asn Glu Gly 
785                 790                 795                 800 


Ile Asp Ala Thr Pro Thr Thr Lys Tyr Asn Glu Leu Leu Lys His Trp 
                805                 810                 815     


Trp Thr Ala Arg Glu Asp Ser Thr Gln Asp Phe Tyr Leu Ser Glu Arg 
            820                 825                 830         


Gln Tyr Asp Ile Tyr Asp Glu Lys Val Cys Phe Thr Ile Asn Ser Ser 
        835                 840                 845             


Ala His Phe Ala Asp Tyr Tyr Ala Pro Ala Leu Ser Lys Ala Tyr Ser 
    850                 855                 860                 


Arg Leu Arg Ala Glu Arg Asp Val Ala Arg Arg Thr Asp Lys Arg Leu 
865                 870                 875                 880 


Pro Pro Val Glu Arg Lys Asp Val Glu Arg Val Phe Lys Asn Thr Ile 
                885                 890                 895     


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
            900                 905                 910         


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asn Gln Gln Gln Leu Lys 
        915                 920                 925             


Leu Ser Lys Met Asp Ser Leu Leu Asn Glu Thr Lys Arg Ile Glu Gln 
    930                 935                 940                 


Val Ile Asn Thr Gln Leu Ser Phe Asp Gln Lys Gly Lys Glu Ile Lys 
945                 950                 955                 960 


Asp Lys Thr Asn Leu Glu Ile Val Lys Thr Ile Val Ala Glu Arg Lys 
                965                 970                 975     


Gln Lys Asn Tyr Thr Glu Met Arg Lys Tyr Val His Asp Arg Arg Leu 
            980                 985                 990         


Pro Glu Leu Phe Glu Tyr Ile Asp  Gly Asn Glu Leu Pro  Leu Asp Met 
        995                 1000                 1005             


Leu Leu  Asn Glu Leu Arg Ala  Tyr Asn Thr Ala Lys  Gln Val Val 
    1010                 1015                 1020             


Phe Asp  Thr Val Phe Ala Leu  Glu Lys Lys Ile Ile  Glu Thr Asp 
    1025                 1030                 1035             


Pro Glu  Gly Leu Lys Gln Leu  Asn Val Ser Lys Asp  Gly Gln Ile 
    1040                 1045                 1050             


Gln Thr  Gly Asn Ile Gln His  Lys Pro Tyr Val Gln  Trp Leu Glu 
    1055                 1060                 1065             


Asn Lys  Gly Leu Ile Thr Asp  Lys Asp Lys Gln Phe  Ile Asn Met 
    1070                 1075                 1080             


Val Arg  Asn Ser Phe Ser His  Asn Gln Phe Pro Gln  Arg Ser Thr 
    1085                 1090                 1095             


Val Glu  Leu Leu Met Pro Val  Trp Gln Asn Thr Asn  Ile Ala Leu 
    1100                 1105                 1110             


Gln Ile  Ala Arg Glu Tyr Gln  Gln Leu Ile Val Asp  Ile Ile Glu 
    1115                 1120                 1125             


Lys Ser  Leu His Pro His Lys  Gln His Gln Met Val  
    1130                 1135                 1140 


<210>  1425
<211>  1135
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1425

Met Asn Thr Val Pro Ala Ser Glu Asn Lys Gly Gln Ser Arg Thr Val 
1               5                   10                  15      


Glu Asp Asp Pro Gln Tyr Phe Gly Leu Tyr Leu Asn Leu Ala Arg Glu 
            20                  25                  30          


Asn Leu Ile Glu Val Glu Ser His Val Arg Ile Lys Phe Gly Lys Lys 
        35                  40                  45              


Lys Leu Asn Glu Glu Ser Leu Lys Gln Ser Leu Leu Cys Asp His Leu 
    50                  55                  60                  


Leu Ser Val Asp Arg Trp Thr Lys Val Tyr Gly His Ser Arg Arg Tyr 
65                  70                  75                  80  


Leu Pro Phe Leu His Tyr Phe Asp Pro Asp Ser Gln Ile Glu Lys Asp 
                85                  90                  95      


His Asp Ser Lys Thr Gly Val Asp Pro Asp Ser Ala Gln Arg Leu Ile 
            100                 105                 110         


Arg Glu Leu Tyr Ser Leu Leu Asp Phe Leu Arg Asn Asp Phe Ser His 
        115                 120                 125             


Asn Arg Leu Asp Gly Thr Thr Phe Glu His Leu Glu Val Ser Pro Asp 
    130                 135                 140                 


Ile Ser Ser Phe Ile Thr Gly Thr Tyr Ser Leu Ala Cys Gly Arg Ala 
145                 150                 155                 160 


Gln Ser Arg Phe Ala Asp Phe Phe Lys Pro Asp Asp Phe Val Leu Ala 
                165                 170                 175     


Lys Asn Arg Lys Glu Gln Leu Ile Ser Val Ala Asp Gly Lys Glu Cys 
            180                 185                 190         


Leu Thr Val Ser Gly Leu Ala Phe Phe Ile Cys Leu Phe Leu Asp Arg 
        195                 200                 205             


Glu Gln Ala Ser Gly Met Leu Ser Arg Ile Arg Gly Phe Lys Arg Thr 
    210                 215                 220                 


Asp Glu Asn Trp Ala Arg Ala Val His Glu Thr Phe Cys Asp Leu Cys 
225                 230                 235                 240 


Ile Arg His Pro His Asp Arg Leu Glu Ser Ser Asn Thr Lys Glu Ala 
                245                 250                 255     


Leu Leu Leu Asp Met Leu Asn Glu Leu Asn Arg Cys Pro Arg Ile Leu 
            260                 265                 270         


Tyr Asp Met Leu Pro Glu Glu Glu Arg Ala Gln Phe Leu Pro Ala Leu 
        275                 280                 285             


Asp Glu Asn Ser Met Asn Asn Leu Ser Glu Asn Ser Leu Asn Glu Glu 
    290                 295                 300                 


Ser Arg Leu Leu Trp Asp Gly Ser Ser Asp Trp Ala Glu Ala Leu Thr 
305                 310                 315                 320 


Lys Arg Ile Arg His Gln Asp Arg Phe Pro Tyr Leu Met Leu Arg Phe 
                325                 330                 335     


Ile Glu Glu Met Asp Leu Leu Lys Gly Ile Arg Phe Arg Val Asp Leu 
            340                 345                 350         


Gly Glu Ile Glu Leu Asp Ser Tyr Ser Lys Lys Val Gly Arg Asn Gly 
        355                 360                 365             


Glu Tyr Asp Arg Thr Ile Thr Asp His Ala Leu Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Asp Phe Gln Asn Glu Glu Glu Val Ser Arg Met Ile Ser Gly Glu 
385                 390                 395                 400 


Ala Ser Tyr Pro Val Arg Phe Ser Leu Phe Ala Pro Arg Tyr Ala Ile 
                405                 410                 415     


Tyr Asp Asn Lys Ile Gly Tyr Cys His Thr Ser Asp Pro Val Tyr Pro 
            420                 425                 430         


Lys Ser Lys Thr Gly Glu Lys Arg Ala Leu Ser Asn Pro Arg Ser Met 
        435                 440                 445             


Gly Phe Ile Ser Val His Asp Leu Arg Lys Leu Leu Leu Met Glu Leu 
    450                 455                 460                 


Leu Cys Glu Gly Ser Phe Ser Arg Met Gln Ser Asp Phe Leu Arg Lys 
465                 470                 475                 480 


Ala Asn Arg Ile Leu Asp Glu Thr Ala Glu Gly Lys Leu Gln Phe Ser 
                485                 490                 495     


Ala Leu Phe Pro Glu Met Arg His Arg Phe Ile Pro Pro Gln Asn Pro 
            500                 505                 510         


Lys Ser Lys Asp Arg Arg Glu Lys Ala Glu Thr Thr Leu Glu Lys Tyr 
        515                 520                 525             


Lys Gln Glu Ile Lys Gly Arg Lys Asp Lys Leu Asn Ser Gln Leu Leu 
    530                 535                 540                 


Ser Ala Phe Asp Met Asn Gln Arg Gln Leu Pro Ser Arg Leu Leu Asp 
545                 550                 555                 560 


Glu Trp Met Asn Ile Arg Pro Ala Ser His Ser Val Lys Leu Arg Thr 
                565                 570                 575     


Tyr Val Lys Gln Leu Asn Glu Asp Cys Arg Leu Arg Leu Arg Lys Phe 
            580                 585                 590         


Arg Lys Asp Gly Asp Gly Lys Ala Arg Ala Ile Pro Leu Val Gly Glu 
        595                 600                 605             


Met Ala Thr Phe Leu Ser Gln Asp Ile Val Arg Met Ile Ile Ser Glu 
    610                 615                 620                 


Glu Thr Lys Lys Leu Ile Thr Ser Ala Tyr Tyr Asn Glu Met Gln Arg 
625                 630                 635                 640 


Ser Leu Ala Gln Tyr Ala Gly Glu Glu Asn Arg Arg Gln Phe Arg Ala 
                645                 650                 655     


Ile Val Ala Glu Leu Arg Leu Leu Asp Pro Ser Ser Gly His Pro Phe 
            660                 665                 670         


Leu Ser Ala Thr Met Glu Thr Ala His Arg Tyr Thr Glu Asp Phe Tyr 
        675                 680                 685             


Lys Cys Tyr Leu Glu Lys Lys Arg Glu Trp Leu Ala Lys Thr Phe Tyr 
    690                 695                 700                 


Arg Pro Glu Gln Asp Glu Asn Thr Lys Arg Arg Ile Ser Val Phe Phe 
705                 710                 715                 720 


Val Pro Asp Gly Glu Ala Arg Lys Leu Leu Pro Leu Leu Ile Arg Arg 
                725                 730                 735     


Arg Met Lys Glu Gln Asn Asp Leu Gln Asp Trp Ile Arg Asn Lys Gln 
            740                 745                 750         


Ala His Pro Ile Asp Leu Pro Ser His Leu Phe Asp Ser Lys Val Met 
        755                 760                 765             


Glu Leu Leu Lys Val Lys Asp Gly Lys Lys Lys Trp Asn Glu Ala Phe 
    770                 775                 780                 


Lys Asp Trp Trp Ser Thr Lys Tyr Pro Asp Gly Met Gln Pro Phe Tyr 
785                 790                 795                 800 


Gly Leu Arg Arg Glu Leu Asn Ile His Gly Lys Ser Val Ser Tyr Ile 
                805                 810                 815     


Pro Ser Asp Gly Lys Lys Phe Ala Asp Cys Tyr Thr His Leu Met Glu 
            820                 825                 830         


Lys Thr Val Arg Asp Lys Lys Arg Glu Leu Arg Thr Ala Gly Lys Pro 
        835                 840                 845             


Val Pro Pro Asp Leu Ala Ala Tyr Ile Lys Arg Ser Phe His Arg Ala 
    850                 855                 860                 


Val Asn Glu Arg Glu Phe Met Leu Arg Leu Val Gln Glu Asp Asp Arg 
865                 870                 875                 880 


Leu Met Leu Met Ala Ile Asn Lys Met Met Thr Asp Arg Glu Glu Asp 
                885                 890                 895     


Ile Leu Pro Arg Leu Lys Asn Ile Asp Ser Ile Leu Asp Lys Glu Asn 
            900                 905                 910         


Gln Phe Ser Leu Ala Val His Ala Lys Val Leu Glu Lys Glu Gly Glu 
        915                 920                 925             


Gly Gly Asp Asn Ser Leu Ser Leu Val Pro Ala Thr Ile Val Ile Lys 
    930                 935                 940                 


Ser Lys Arg Lys Asp Trp Ser Lys Tyr Ile Arg Tyr Arg Tyr Asp Arg 
945                 950                 955                 960 


Arg Val Pro Gly Leu Met Ser His Phe Pro Glu His Lys Ala Thr Leu 
                965                 970                 975     


Asp Glu Val Lys Thr Leu Leu Gly Glu Tyr Asp Arg Cys Arg Ile Lys 
            980                 985                 990         


Ile Phe Asp Trp Ala Phe Ala Leu  Glu Gly Ala Ile Met  Ser Asp Arg 
        995                 1000                 1005             


Asp Leu  Lys Pro Tyr Leu His  Glu Ser Ser Ser Arg  Glu Gly Lys 
    1010                 1015                 1020             


Ser Gly  Glu His Ser Thr Leu  Val Lys Met Leu Val  Glu Lys Lys 
    1025                 1030                 1035             


Gly Cys  Leu Thr Pro Asp Glu  Ser Gln Tyr Leu Ile  Leu Ile Arg 
    1040                 1045                 1050             


Asn Lys  Ala Ala His Asn Gln  Phe Pro Cys Ala Ala  Glu Ile Pro 
    1055                 1060                 1065             


Leu Ile  Tyr Arg Asp Val Ser  Ala Lys Val Gly Ser  Ile Glu Gly 
    1070                 1075                 1080             


Ser Ser  Ala Lys Asp Leu Pro  Glu Gly Ser Ser Leu  Val Asp Ser 
    1085                 1090                 1095             


Leu Trp  Lys Lys Tyr Glu Met  Ile Ile Arg Lys Ile  Leu Pro Ile 
    1100                 1105                 1110             


Leu Asp  Pro Glu Asn Arg Phe  Phe Gly Lys Leu Leu  Asn Asn Met 
    1115                 1120                 1125             


Ser Gln  Pro Ile Asn Asp Leu  
    1130                 1135 


<210>  1426
<211>  1175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1426

Met Thr Glu Gln Asn Glu Lys Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Ala His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Cys Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Gly Thr Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Thr Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Gly Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Cys Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Leu Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Asn Tyr Ser Asp Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Gly Glu Ile Asp Thr Leu Asp 
    530                 535                 540                 


Arg Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Glu Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Ser Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Tyr Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Asp Leu Glu Ala Trp Ser His Ser Ala Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Val Gly Ile Glu Tyr Ala Ser Trp Glu Asn 
    850                 855                 860                 


Lys Lys Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Glu Thr 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Lys Ala Asp Lys Ile Asn Ile Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Ala Lys Glu His Pro Tyr Leu Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asp Ile Arg Thr 
945                 950                 955                 960 


Glu Val Gln Glu Gln Gly Ser Leu Asn Val Leu Asn Arg Val Lys Ser 
                965                 970                 975     


Met Arg Leu Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val 
            980                 985                 990         


His Lys Glu Gln Ala Pro Leu Ala  Thr Val Tyr Ile Glu  Glu Arg Asp 
        995                 1000                 1005             


Thr Lys  Leu Leu Lys Gln Gly  Asn Phe Lys Ser Phe  Val Lys Asp 
    1010                 1015                 1020             


Arg Arg  Leu Asn Gly Leu Phe  Ser Phe Val Asp Thr  Gly Gly Leu 
    1025                 1030                 1035             


Ala Met  Glu Gln Tyr Pro Ile  Ser Lys Leu Arg Val  Glu Tyr Glu 
    1040                 1045                 1050             


Leu Ala  Lys Tyr Gln Thr Ala  Arg Val Cys Ala Phe  Glu Gln Thr 
    1055                 1060                 1065             


Leu Glu  Leu Glu Glu Ser Leu  Leu Thr Arg Tyr Pro  His Leu Pro 
    1070                 1075                 1080             


Asp Lys  Asn Phe Arg Lys Met  Leu Glu Ser Trp Ser  Asp Pro Leu 
    1085                 1090                 1095             


Leu Asp  Lys Trp Pro Asp Leu  His Arg Lys Val Arg  Leu Leu Ile 
    1100                 1105                 1110             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1115                 1120                 1125             


Glu Ala  Val Phe Ser Ser Ile  Arg Lys Tyr Asp Pro  Ser Ser Leu 
    1130                 1135                 1140             


Asp Ala  Ile Glu Glu Arg Met  Gly Leu Asn Ile Ala  His Arg Leu 
    1145                 1150                 1155             


Ser Glu  Glu Val Lys Gln Ala  Lys Glu Met Val Glu  Arg Ile Ile 
    1160                 1165                 1170             


Gln Val  
    1175 


<210>  1427
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1427

Met Lys Ala Asn Asn Gln Ile Val Lys Gly Ile Ser Tyr Asp His Leu 
1               5                   10                  15      


Lys Pro Asp Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asp Gly Val Ile Gln Glu Phe Thr Met Arg Leu Asn Leu 
        35                  40                  45              


Lys Tyr Asp Pro Glu Asn Lys Asn Gln Ser Leu Phe Ser Tyr Phe Asp 
    50                  55                  60                  


Ile Asn Ala Ser Phe Thr Asp Trp Glu Arg Gly Val Asn Ile Leu Lys 
65                  70                  75                  80  


Glu Tyr Trp Pro Val Met Glu Phe Ile Asp Arg Pro Ala Thr Asp Lys 
                85                  90                  95      


Gln Phe Glu Ser Glu Lys Pro Glu Asn Arg Glu Ala Ala Lys Arg Lys 
            100                 105                 110         


Tyr Phe Ile Ala Thr Leu Arg Ile Leu Leu Lys Ser Ile Lys Glu Leu 
        115                 120                 125             


Arg His Tyr Tyr Thr His Tyr Tyr His Pro Pro Val Gln Leu Ser Glu 
    130                 135                 140                 


Asp Leu Phe Arg Phe Leu Asp His Thr Leu Leu Tyr Thr Ala Phe Asp 
145                 150                 155                 160 


Val Lys Lys Thr Lys Met Lys Asp Asp Lys Thr Arg Gln Leu Leu Asn 
                165                 170                 175     


Gln Asn Leu Ser Leu Glu Leu Glu Lys Leu Lys Lys Leu Lys Val Glu 
            180                 185                 190         


Glu Leu Lys Lys Lys Lys Glu Lys Gly Ile Lys Val Asn Leu Gln Asp 
        195                 200                 205             


Glu Lys Gly Ile Leu Asn Ala Ile Tyr Asn Asp Ala Phe Ala His Ile 
    210                 215                 220                 


Ile Thr Lys Glu Lys Asp Ser Asp Lys Asp Glu Leu Glu Thr Arg Tyr 
225                 230                 235                 240 


Lys Ser Thr Leu Pro Gln Asp Glu Thr Ala Glu Ala Gly Ile Asn Ile 
                245                 250                 255     


Ser Ile Ser Gly Leu Ile Phe Leu Leu Ser Leu Phe Leu Ser Arg Lys 
            260                 265                 270         


Glu Ile Glu Gln Leu Lys Ser Asn Ile Glu Gly Tyr Lys Gly Lys Val 
        275                 280                 285             


Leu Asn Ile Glu Thr Glu Val Asp Arg Lys His Asn Ser Leu Lys Tyr 
    290                 295                 300                 


Met Ala Thr His Trp Val Phe Ser Ile Leu Ala Phe Lys Gly Leu Lys 
305                 310                 315                 320 


Gln Arg Leu Thr Asn Ser Phe Lys Lys Glu Ser Leu Leu Ile Gln Met 
                325                 330                 335     


Met Asp Glu Leu Asn Lys Val Pro Asp Glu Leu Tyr Gln Thr Leu Ser 
            340                 345                 350         


Glu Thr Ser Lys Lys Glu Phe Leu Glu Asp Ile Asn Glu Tyr Val Ser 
        355                 360                 365             


Glu Gly Asp Asp Asp Glu Lys Ala Thr Tyr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Ser Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gln Phe Pro Thr Leu Lys Phe Gln Ile Phe Val Gly 
                405                 410                 415     


Gln Tyr Leu His Asp Asn Arg Pro Lys Thr Leu Ala Ser Asn Gly Met 
            420                 425                 430         


Thr Ala Gln Arg Met Ile Lys Glu Lys Ile Asn Leu Phe Gly Asn Leu 
        435                 440                 445             


Ser Glu Val Thr Lys His Lys Ser Asp Phe Phe Glu Lys Glu Ser Ala 
    450                 455                 460                 


Val Gln Gly Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Trp Ala Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Val Tyr Ile Asp Leu Ile Gly Lys Glu Gly Lys Ala 
                485                 490                 495     


Lys Glu Ile Gln Val Gln Ile Asn Lys Tyr Arg Lys Gln Leu Asn Pro 
            500                 505                 510         


Ala Pro Gln Arg Asp Lys Arg Ile Ser Lys Lys Glu Ile Ile Glu Gln 
        515                 520                 525             


Leu Tyr Lys Glu Lys Val Val Tyr Gly Asp Pro Thr Leu Met Leu Ser 
    530                 535                 540                 


Ala Asn Glu Leu Met Ala Leu Leu Tyr Glu Leu Ile Val Asn Gly Lys 
545                 550                 555                 560 


Ser Gly Ala Glu Leu Glu Asn Lys Ile Val Glu Gln Ile Ile Ala Arg 
                565                 570                 575     


Tyr Glu Gln Ile Glu Ala Tyr Asp Pro Thr Thr Gln Gln Leu Pro Thr 
            580                 585                 590         


Asn Gln Met Pro His Lys Leu Gln Lys Ser Arg Lys Asp Ser Lys Val 
        595                 600                 605             


Thr Asp Thr Asp Lys Leu Leu Lys Thr Ile Asp Lys Glu Ile Asp Glu 
    610                 615                 620                 


Gly Asn Lys Lys Leu Glu Leu Ile Ala Cys His Arg Lys Glu Trp Glu 
625                 630                 635                 640 


Glu Ala Glu Gln Arg Lys Lys Ser Gly Lys Arg Asn Asn Pro Gly Thr 
                645                 650                 655     


Lys Ser Arg Lys His Leu Phe Tyr Ala Ser Glu Met Gly Glu Glu Ala 
            660                 665                 670         


Thr Trp Ile Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Pro Ala Arg 
        675                 680                 685             


Ala Glu Trp Lys Gly Thr His His Ser Glu Leu Gln Arg Leu Leu Ala 
    690                 695                 700                 


Phe Tyr Ser Thr Gln Arg Leu Glu Ala Trp Gln Leu Val Glu Ser Val 
705                 710                 715                 720 


Trp Thr Ala Asn Thr His Ser Phe Trp Glu Glu Asn Phe Lys Glu Ala 
                725                 730                 735     


Phe Tyr Lys Pro Glu Phe Glu Asn Phe Tyr Gly Ala Tyr Ile Glu Ile 
            740                 745                 750         


Arg Thr Lys Ile Leu Thr Thr Cys Arg Ser Ile Leu Glu Asn Asn Pro 
        755                 760                 765             


Glu Ala Thr Met Asn Asn Asp Thr Glu Lys Glu Trp Asp Lys Val Phe 
    770                 775                 780                 


Thr Leu Phe Asp Lys Arg Leu Tyr Arg Thr Ser Thr Thr Asp Glu Gln 
785                 790                 795                 800 


Lys Lys Gln Leu Leu Thr Lys Pro Phe Ala Phe Pro Arg Gly Leu Phe 
                805                 810                 815     


Asp Asp Lys Pro Thr Phe Leu Pro Gly Ser Lys Pro Asn Glu Asn Pro 
            820                 825                 830         


Glu Arg Phe Ala Ala Trp Tyr Ser Tyr Gly Tyr Thr Tyr Ser Gly Lys 
        835                 840                 845             


Phe Gln Ser Phe Tyr Asp Met Pro Arg Asn Tyr Ser Asp Trp Tyr Lys 
    850                 855                 860                 


Lys Leu Lys Glu Asp Gly Lys Leu Pro Arg Leu Asp Lys Lys Thr Glu 
865                 870                 875                 880 


Gln Glu Lys Ile Leu Arg Phe Arg Met Asp Cys Asp Leu Asn Ile Lys 
                885                 890                 895     


His Ile Arg Phe Gln Asp Ile Tyr Val Lys Leu Met Val Asp Ser Leu 
            900                 905                 910         


Tyr Lys Ala Val Phe Gly Gln Gln Pro Glu Phe Asp Leu Ser His Leu 
        915                 920                 925             


Tyr Asp Thr Arg Ser Glu Arg Tyr Glu Asn Asn Thr Ile Ala Gln Arg 
    930                 935                 940                 


Gln Lys Ser Arg Gln Glu Gly Asp Asn Ser Asp Asn Ala Ile Asn Glu 
945                 950                 955                 960 


Asn Tyr Val Trp Asn Lys Thr Phe Ala Ile Ser Leu Tyr Asn Gly Arg 
                965                 970                 975     


Ile Thr Glu Ser Gln Val Lys Leu Lys Asp Val Gly Lys Phe Arg Arg 
            980                 985                 990         


Phe Ala Thr Asp Pro Arg Val Gln  Thr Leu Ile Ser Tyr  Asp Asp Thr 
        995                 1000                 1005             


Arg Thr  Trp Thr Lys Leu Glu  Ile Glu Asn Glu Leu  Asp Asn Lys 
    1010                 1015                 1020             


Ala Asp  Ala Tyr Glu Pro Ile  Arg Arg Thr Gln Ser  Leu Lys Ala 
    1025                 1030                 1035             


Ile Gln  Gln Leu Glu Lys Asn  Ile Leu Lys Lys Asn  Gly Phe Asn 
    1040                 1045                 1050             


Gly Lys  Gln His Pro Glu Glu  Leu Lys His Asn Gly  Asn Pro Asn 
    1055                 1060                 1065             


Phe Arg  Lys Tyr Ile Ala Asn  Gly Leu Leu Lys His  Arg Thr Asp 
    1070                 1075                 1080             


Ile Arg  Gln Glu Glu Leu Ala  Leu Ile Ser Asp Thr  Glu Phe Gln 
    1085                 1090                 1095             


Glu Ile  Gly Leu Glu Arg Ile  Arg Gln Thr Asn Pro  Leu Ile Gln 
    1100                 1105                 1110             


Lys Ala  Tyr Leu Leu Ile Leu  Leu Arg Asn Lys Phe  Gly His Asn 
    1115                 1120                 1125             


Gln Leu  Pro Asp Gln Glu His  Phe Arg Leu Met Arg  Ser Ile Tyr 
    1130                 1135                 1140             


Pro Tyr  Asn Gln Gln Glu Ser  Tyr Ser Ala Tyr Phe  Asn His Val 
    1145                 1150                 1155             


Ile Thr  Gln Ile Ile Glu Glu  Leu Asn Thr 
    1160                 1165             


<210>  1428
<211>  1140
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1428

Met Glu Asn Asp Gln Gln Ile Leu Glu Asn Arg Arg Arg Thr Leu Ala 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Ser Asn His Leu Ala Ala Ser Phe Glu Gln Lys Val 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ala Ser Phe Leu Cys Asn Lys Ser 
    50                  55                  60                  


Ile Lys Lys Ile Asn Trp Asn His Val Tyr Ser Lys Ala Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ala Asp Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Arg Glu Thr Thr Asp Lys Glu Gly Lys Asp Phe Thr Ala Met Asn Glu 
            100                 105                 110         


Thr Leu Lys Leu Val Phe Asp Glu Leu Gln Ala Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Ala Asp Ser Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Val Glu Leu Ala Asp Phe Leu Thr Val Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Ala Asp Asp Asp Tyr 
                165                 170                 175     


Thr Met Val Glu Ser Lys Gln Ile Val Thr Pro Asp Asn Leu Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Val Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Leu Ala Tyr Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asp Leu Gly Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Glu 
            260                 265                 270         


Val Ile Thr Glu Glu Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Glu Glu Glu Arg 
    290                 295                 300                 


Glu Lys Ile Leu Asp Glu Ile Asp Tyr Glu Asp Tyr Ile Glu Ser Leu 
305                 310                 315                 320 


Thr Arg Arg Val Arg His Ser Asn Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Lys Tyr Asn Lys Gln Phe Asp Gly Glu 
        355                 360                 365             


Ala Thr Glu Cys Lys Val Val Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asn Gln Glu Thr Val Glu Leu Lys Ile Asp Ser Ala 
385                 390                 395                 400 


Gln Arg Thr Asn Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Glu Ala Arg Leu Leu 
            420                 425                 430         


Thr Lys Ala Lys Pro Glu Ser Lys Val Ser Tyr Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Ile Leu Cys Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Lys Ala Glu Glu Met Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Lys Val Asn Asp Ser Gln Leu Met Ser Met Gln Phe Ile Asp Glu 
                485                 490                 495     


Ile Lys Glu Gln Leu Pro Ala Asp Trp Asn Glu Phe Gly Lys Arg Ser 
            500                 505                 510         


Asp Ser Lys Lys Lys Lys Ala Tyr Thr Asn Ala Ala Leu Gln Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Lys Val Leu Ala Asn Tyr Gln Leu 
    530                 535                 540                 


Asn Asp Lys Gln Val Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Ser Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Val Glu Lys His Lys Leu 
            580                 585                 590         


Asp Lys Ser Ala Arg Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Thr Asp Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Phe Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Tyr 
625                 630                 635                 640 


Ala Asp Thr Asp Lys Lys Ala Thr Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Lys Gly Gly His Pro Phe Leu Ala Asn Ile Asn 
            660                 665                 670         


Leu Arg Gln Ile Arg Lys Thr Ser Gln Leu Tyr Glu Leu Tyr Leu Val 
        675                 680                 685             


Glu Lys Ala Asn Lys Gln Val Lys Lys Met Asn Pro Lys Thr Gln Arg 
    690                 695                 700                 


Thr Ser Asn Val Asp Glu Ser Trp Met Met Lys Ser Phe Tyr Ala Lys 
705                 710                 715                 720 


Glu Trp Asn Glu Glu Met Gly Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Val Asn Lys Thr Asn Ile Pro Phe Thr Ile Arg Gln Trp Glu Glu Lys 
            740                 745                 750         


Glu Lys His Asn Leu Gln Ala Trp Leu His Asn Ile Thr Lys Gly Lys 
        755                 760                 765             


Thr Ser Lys Asp Gly Lys Lys Ala Ile Asp Leu Pro Thr Asn Leu Phe 
    770                 775                 780                 


Asp Asp Thr Leu Cys Glu Leu Leu Arg Glu Ala Leu Ile Asn Gln Gly 
785                 790                 795                 800 


Ile Asp Ala Thr Pro Thr Thr Lys Tyr Asn Glu Leu Leu Lys Gln Trp 
                805                 810                 815     


Trp Thr Ala Arg Glu Asp Ser Thr Gln Asp Phe Tyr Leu Ser Glu Arg 
            820                 825                 830         


Gln Tyr Asp Ile Tyr Asp Glu Lys Val Cys Phe Thr Ile Asn Ser Ser 
        835                 840                 845             


Ala His Phe Ala Asp Tyr Tyr Ala Pro Ala Leu Asn Lys Ala Tyr Ser 
    850                 855                 860                 


Arg Leu Arg Ala Glu Arg Asp Val Ala Arg Arg Thr Asp Lys Arg Leu 
865                 870                 875                 880 


Pro Pro Val Glu Arg Lys Asp Val Glu Arg Val Phe Lys Asn Thr Ile 
                885                 890                 895     


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
            900                 905                 910         


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asn Gln Gln Gln Leu Lys 
        915                 920                 925             


Leu Ser Lys Met Asp Ser Leu Leu Asn Glu Thr Lys Arg Ile Glu Gln 
    930                 935                 940                 


Thr Ile Asn Thr Gln Leu Ser Phe Asp His Lys Gly Lys Glu Ile Lys 
945                 950                 955                 960 


Asp Lys Thr Asn Ser Glu Ile Val Lys Thr Ile Val Ala Glu Arg Lys 
                965                 970                 975     


Gln Lys Asn Tyr Thr Glu Met Arg Lys Tyr Val His Asp Arg Arg Leu 
            980                 985                 990         


Pro Glu Leu Phe Glu Tyr Ile Asp  Gly Asn Glu Leu Pro  Leu Asp Val 
        995                 1000                 1005             


Leu Leu  Asn Glu Leu Arg Ala  Tyr Asn Thr Ala Lys  Gln Met Val 
    1010                 1015                 1020             


Phe Asp  Thr Val Phe Ala Leu  Glu Lys Lys Ile Ile  Glu Thr Asp 
    1025                 1030                 1035             


Pro Glu  Gly Leu Lys Gln Leu  Asn Val Gly Lys Asn  Gly Gln Ile 
    1040                 1045                 1050             


Gln Thr  Gly Asn Ile Gln His  Lys Pro Tyr Val Gln  Trp Leu Glu 
    1055                 1060                 1065             


Asn Lys  Gly Leu Ile Thr Asp  His Gln Lys Gln Phe  Ile Asn Met 
    1070                 1075                 1080             


Val Arg  Asn Ser Phe Ser His  Asn Gln Phe Pro Gln  Arg Ser Thr 
    1085                 1090                 1095             


Val Glu  Leu Leu Met Pro Glu  Trp Gln Asn Thr Asp  Ile Ala Leu 
    1100                 1105                 1110             


Gln Ile  Ala Arg Glu Tyr Gln  Gln Leu Ile Val Asp  Ile Ile Glu 
    1115                 1120                 1125             


Lys Ser  Leu His Pro His Lys  Gln His Gln Met Val  
    1130                 1135                 1140 


<210>  1429
<211>  1129
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1429

Met Glu Thr Asn Gln Gln Thr His Glu Asn Arg Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Asn Asn His Val Ala Thr Asp Phe Lys Arg Lys Pro 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Asp Ala Leu Leu Cys Asn Lys Thr 
    50                  55                  60                  


Ile Lys Asn Leu Asn Trp Asn His Val His Thr Arg Ala Leu Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ser Glu Ser Leu Pro Lys Asp Glu 
                85                  90                  95      


Arg Lys Asn Ser Asp Thr Glu Gly Lys Asp Phe Thr Ser Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Ser Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Asp Ser Arg Lys Leu Ile Val 
    130                 135                 140                 


Ser Pro Glu Leu Ala Asn Phe Leu Thr Ile Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Thr Tyr Thr Lys Ala Arg Met Lys Asp Val Leu Thr Asp Ala Asp Tyr 
                165                 170                 175     


Ala Leu Val Glu Asn Leu Gln Met Val Ala Thr Asp Asn Lys Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ala Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asn Gln Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Ser 
            260                 265                 270         


Ile Ile Thr Asp Lys Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Glu Asn Leu Ile Ala Asn Ser Thr Asn Asn Glu Glu Arg 
    290                 295                 300                 


Glu Arg Ile Leu Asp Glu Ile Asp Tyr Gln Asp Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg Tyr Asn Asn Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Asp Glu Lys Asn Ile Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Asn Tyr Thr Lys Gln Phe Ala Gly Glu 
        355                 360                 365             


Gln Ala Glu Arg Lys Val Leu Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asp Pro Glu Leu Ser Gln Gln Arg Ile Asp Lys Gln 
385                 390                 395                 400 


Gln Gln Thr Ala Gly Phe Glu Gln Phe Ala Pro Arg Tyr His Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Asn Ile Ala Thr Leu Thr 
            420                 425                 430         


Ala Lys Ser Lys Ala Gly Ser Lys Val Glu His Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Gln Ala Glu Glu Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Ile Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Ser Gln Leu Pro Asp Gly Trp Asn Glu Phe Asn Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asp Ser Thr Leu Arg Tyr Leu 
        515                 520                 525             


His Gln Arg Lys Thr Ile Leu Asn Thr Ile Leu Ser Lys Tyr Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Lys Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Thr Arg Leu Lys Ala Val Glu Lys His Lys Leu 
            580                 585                 590         


Asn Lys Ser Val Lys Ile Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Glu Glu Lys Lys Lys Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Thr Asn Ala Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Asn Asp Gly His Pro Phe Leu Gln Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Gln Ala Tyr Leu Ile 
        675                 680                 685             


Glu Lys Gly Asn Lys Met Val Pro Arg Leu Asn Pro Lys Thr Asn Lys 
    690                 695                 700                 


Thr Ser Lys Val Asp Glu Ser Trp Met Met Lys Gln Phe Tyr Val Lys 
705                 710                 715                 720 


Glu Trp Lys Glu Glu Ile Ala Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Ser Arg Ile Pro Phe Thr Ile Arg Gln Trp Asp Glu Lys 
            740                 745                 750         


Glu Lys Tyr Asp Leu Asn Thr Trp Leu Arg His Val Thr Val Gly Lys 
        755                 760                 765             


Asn Asn Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe Asp 
    770                 775                 780                 


Glu Ala Leu Cys Asp Leu Leu Arg Glu Gln Leu Asp Thr Lys Ile Val 
785                 790                 795                 800 


Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Ile Trp Trp 
                805                 810                 815     


Lys Thr Arg Asn Asp Asp Thr Gln Gln Phe Tyr Gln Ser Glu Arg Glu 
            820                 825                 830         


Tyr Asn Ile Tyr Asn Glu Lys Val Arg Phe Lys Ile Asp Ser Ser Ala 
        835                 840                 845             


His Phe Ala Asp Tyr Tyr Lys Asn Ala Leu Ser Arg Ala Phe Thr Arg 
    850                 855                 860                 


Leu Lys Ala Glu Arg Glu Thr Ala Arg Gln Ser Asn Lys Arg Leu Pro 
865                 870                 875                 880 


Pro Leu Glu Tyr Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile Ala 
                885                 890                 895     


Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met Ala 
            900                 905                 910         


Val Leu Met Leu Glu Arg Leu Met Asp Asn Ser Pro Asn Leu Arg Leu 
        915                 920                 925             


Ser Lys Ile Glu Thr Leu Leu Asn Asp Thr Thr Pro Ile Arg Glu Lys 
    930                 935                 940                 


Ile Ser Ala Thr Leu Ser Phe Asp Ala Ser Gly Glu Arg Ile Ser Gly 
945                 950                 955                 960 


Lys Ser Asn Pro Thr Val Thr Lys Thr Leu Val Ala Glu Arg Lys Gln 
                965                 970                 975     


Lys Asn Tyr Thr Glu Leu Arg Lys Tyr Arg Tyr Asp Arg Arg Leu Pro 
            980                 985                 990         


Glu Leu Phe Glu Tyr Val Gln Ala  Asp Glu Ile Pro Leu  Glu Trp Leu 
        995                 1000                 1005             


Leu Glu  Glu Leu Ser Ala Tyr  Asn Asn Ala Lys Gln  Gln Val Phe 
    1010                 1015                 1020             


Asp Thr  Val Phe Thr Leu Glu  Lys Lys Ile Ile Gly  Thr Asp Pro 
    1025                 1030                 1035             


Asp Gly  Leu Lys Ser Leu Phe  Thr Gly Ala Asn Gly  Glu Leu Gln 
    1040                 1045                 1050             


Thr Gly  Asn Ile Gln His Lys  Pro Tyr Val Gln Trp  Leu Thr Asn 
    1055                 1060                 1065             


Lys Gly  Leu Ile Asn Lys Glu  Glu Lys Gln Phe Ile  Asn Met Val 
    1070                 1075                 1080             


Arg Lys  Cys Phe Ser His Asn  Gln Phe Pro Gln Arg  Lys Thr Met 
    1085                 1090                 1095             


Glu Leu  Leu Ile Pro Ala Trp  Asn Glu Lys Lys Leu  Ala Leu Gln 
    1100                 1105                 1110             


Ile Ala  Thr Val Tyr Asn Gln  Leu Ile Ala Asp Leu  Thr Asn Lys 
    1115                 1120                 1125             


Ile 
    


<210>  1430
<211>  1119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1430

Met Thr Glu Gln Asn Glu Arg Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Phe Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Ala His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Cys His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Cys Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Gly Lys Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Thr Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Leu Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Asp Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Asp Glu Ile Asn Thr Arg Asp 
    530                 535                 540                 


Glu Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Thr Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Ser Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly His Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Asp Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Leu Ala Lys Leu Lys Lys Glu Ile Leu Glu Ala 
        835                 840                 845             


Lys Glu His Pro Tyr Leu Asp Phe Lys Ser Trp Gln Lys Phe Glu Arg 
    850                 855                 860                 


Glu Leu Arg Leu Val Lys Asn Gln Asp Ile Ile Thr Trp Met Met Cys 
865                 870                 875                 880 


Arg Asp Leu Met Glu Glu Asn Lys Val Glu Gly Leu Asp Thr Gly Thr 
                885                 890                 895     


Leu Tyr Leu Lys Asp Ile Arg Thr Glu Val Gln Glu Gln Gly Ser Leu 
            900                 905                 910         


Asn Val Leu Asn Arg Val Lys Pro Met Arg Leu Pro Val Val Val Tyr 
        915                 920                 925             


Arg Ala Asp Ser Arg Gly His Val His Lys Glu Gln Ala Pro Leu Ala 
    930                 935                 940                 


Thr Val Tyr Ile Glu Glu Arg Asp Thr Lys Leu Leu Lys Gln Gly Asn 
945                 950                 955                 960 


Phe Lys Ser Phe Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe 
                965                 970                 975     


Val Asn Thr Gly Gly Leu Ala Met Glu Gln Tyr Pro Ile Ser Lys Leu 
            980                 985                 990         


Arg Val Glu Tyr Glu Leu Ala Lys  Tyr Gln Thr Ala Arg  Val Cys Ala 
        995                 1000                 1005             


Phe Glu  Gln Thr Leu Glu Leu  Glu Glu Ser Leu Leu  Thr Arg Tyr 
    1010                 1015                 1020             


Pro His  Leu Pro Asp Lys Asn  Phe Arg Lys Met Leu  Glu Ser Trp 
    1025                 1030                 1035             


Ser Asp  Pro Leu Leu Asp Lys  Trp Pro Asp Leu His  Arg Lys Val 
    1040                 1045                 1050             


Arg Leu  Leu Ile Ala Val Arg  Asn Ala Phe Ser His  Asn Gln Tyr 
    1055                 1060                 1065             


Pro Met  Tyr Asp Glu Ala Val  Phe Ser Ser Ile Arg  Lys Tyr Asp 
    1070                 1075                 1080             


Pro Ser  Ser Pro Asp Ala Ile  Glu Glu Arg Met Gly  Leu Asn Ile 
    1085                 1090                 1095             


Ala His  Arg Leu Ser Glu Glu  Val Lys Gln Ala Lys  Lys Met Ala 
    1100                 1105                 1110             


Glu Arg  Ile Ile Gln Ala 
    1115                 


<210>  1431
<211>  1175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1431

Met Thr Glu Gln Asn Glu Lys Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Phe Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Thr His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Cys Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Glu Lys Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Ala Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Ala 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Phe Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Asp Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Gly Glu Ile Asp Thr Leu Asp 
    530                 535                 540                 


Arg Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Lys His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Gly Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Tyr Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Ser Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Gln Asp Leu Glu Ala Trp Ser His Ser Ala Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Ala Gly Ile Glu Asn Ala Ser Arg Glu Asn 
    850                 855                 860                 


Lys Lys Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Glu Ala 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Lys Ala Asp Lys Ile Asn Ile Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Ala Lys Glu His Pro Tyr His Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asp Ile Arg Thr 
945                 950                 955                 960 


Glu Val Gln Glu Gln Gly Ser Leu Asn Val Leu Asn His Val Lys Pro 
                965                 970                 975     


Met Arg Leu Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val 
            980                 985                 990         


His Lys Glu Gln Ala Pro Leu Ala  Thr Val Tyr Ile Glu  Glu Arg Asp 
        995                 1000                 1005             


Thr Lys  Leu Leu Lys Gln Gly  Asn Phe Lys Ser Phe  Val Lys Asp 
    1010                 1015                 1020             


Arg Arg  Leu Asn Gly Leu Phe  Ser Phe Val Asp Thr  Gly Gly Leu 
    1025                 1030                 1035             


Ala Met  Glu Gln Tyr Pro Ile  Ser Lys Leu Arg Val  Glu Tyr Glu 
    1040                 1045                 1050             


Leu Ala  Lys Tyr Gln Thr Ala  Arg Val Cys Val Phe  Glu Gln Thr 
    1055                 1060                 1065             


Leu Glu  Leu Glu Glu Ser Leu  Leu Thr Arg Tyr Pro  His Leu Pro 
    1070                 1075                 1080             


Asp Lys  Asn Phe Arg Lys Met  Leu Glu Ser Trp Ser  Asp Pro Leu 
    1085                 1090                 1095             


Leu Ala  Lys Trp Pro Glu Leu  His Glu Lys Val Arg  Leu Leu Ile 
    1100                 1105                 1110             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1115                 1120                 1125             


Glu Ala  Val Phe Ser Pro Ile  Arg Lys Tyr Asp Pro  Ser Ser Pro 
    1130                 1135                 1140             


Asp Ala  Ile Glu Glu Arg Met  Gly Leu Asn Ile Ala  His Arg Leu 
    1145                 1150                 1155             


Ser Glu  Glu Val Lys Gln Ala  Lys Glu Met Val Glu  Arg Ile Ile 
    1160                 1165                 1170             


Gln Ala  
    1175 


<210>  1432
<211>  981
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1432

Met Ala Asp Lys Thr Ala Glu Leu Cys Leu Phe Tyr Asn Leu Ala Leu 
1               5                   10                  15      


Asn Arg Val Asn Asp Leu Val Arg Lys Tyr Glu Lys Asp Asp Thr Leu 
            20                  25                  30          


His Ile Glu Asp Val Asn Trp Glu Thr Phe Gly Gly Phe Arg Asn Val 
        35                  40                  45              


Ser Thr Tyr Leu His Leu Gln Val Phe Met Trp Lys Glu Pro Leu Ser 
    50                  55                  60                  


Ala Ser Phe Thr Thr Leu Ser Thr Ala Asp Lys Lys Arg Ile His Glu 
65                  70                  75                  80  


Leu Leu Arg Lys Leu Val Asp Leu Arg Asn Tyr Gln Ser His Tyr Tyr 
                85                  90                  95      


His Asp Ala Ser Val Leu Lys Phe Pro Gln Glu Leu Ile Asp Phe Ile 
            100                 105                 110         


Tyr Ser Arg Tyr Ala Asn Ala Arg Asn Ala Leu Glu Leu Lys Tyr Pro 
        115                 120                 125             


Glu Phe Val Thr Trp Phe His Asp Leu Asn Glu Asp Lys Val Ile Phe 
    130                 135                 140                 


Lys Asn Ser Lys Gly Glu Glu Arg Glu Asp Val Tyr Arg His Phe Tyr 
145                 150                 155                 160 


Phe Phe Asn Ala Asn Gly Asn Ile Glu Pro Glu Gly Lys Asn Phe Phe 
                165                 170                 175     


Leu Ser Phe Phe Leu Leu Lys Gly Glu Met Ser Lys Phe Leu Lys Lys 
            180                 185                 190         


Arg Ser Arg Cys Lys Arg Asp Asn Gly Glu Lys Tyr Gln Val Lys Thr 
        195                 200                 205             


Arg Leu Tyr Thr Tyr Tyr Cys His Arg Asp Gly Ser Asn Arg Phe Phe 
    210                 215                 220                 


Leu Glu Gly Lys Glu Glu Tyr Met Asp Thr Glu Glu Arg Leu Arg Arg 
225                 230                 235                 240 


Gln Gly Asn Thr Leu Leu Asn Tyr Leu Lys Ser Arg Pro Leu Val Asp 
                245                 250                 255     


Leu Lys Tyr Leu Pro Pro Ala Pro Pro Pro Gln Leu Leu Ser Lys Lys 
            260                 265                 270         


Glu Val Glu Glu Arg Lys Asn Arg Ala Glu Ser Gln Ala Glu Glu Glu 
        275                 280                 285             


Lys Thr Tyr Ile Arg Arg Thr Asp Lys Phe Ala Ser Leu Val Val Arg 
    290                 295                 300                 


Tyr Phe Met Asp Arg Ala Phe Leu Gly Tyr Glu Gln Glu Pro Cys Phe 
305                 310                 315                 320 


Tyr Trp His Val Lys Ser Leu Asp Leu Glu Glu Val Gln Lys Gln Lys 
                325                 330                 335     


Gln Glu Asn Arg Val Tyr Asp Ala Glu Gly Ala Tyr Tyr Tyr Gln Lys 
            340                 345                 350         


Glu Ser Arg Trp Ser Pro His Phe Val Pro Gly Glu Phe Pro Val Phe 
        355                 360                 365             


Val Asn Gly His Ile Lys Phe Arg Leu Gly Pro Glu Gly Met Glu Tyr 
    370                 375                 380                 


Ala Ile Ser Thr Gly Glu Leu Lys Asn Met Leu Tyr Leu Leu Leu Asn 
385                 390                 395                 400 


Ser Pro Arg Lys Asn Met Thr Glu Ile Gln Asp Ala Leu Leu Arg Tyr 
                405                 410                 415     


Gly Thr Gln Phe Ser Asn Ala Met Arg Glu Leu Thr Thr Glu His Asn 
            420                 425                 430         


Ile Arg Tyr Glu Ala Tyr Pro Leu Val Phe Glu Lys Gly Arg Asp Ser 
        435                 440                 445             


Val Leu Leu Ser Lys Met His Arg Lys Val Leu Asp Lys Glu Lys Phe 
    450                 455                 460                 


Asp Ala Ala Ile Tyr Thr Ala Ala Leu Glu Lys Ala Leu Asp Ser Arg 
465                 470                 475                 480 


Leu Arg Trp Val Glu Tyr Asn Cys Lys Pro Glu Val Tyr Thr Leu Tyr 
                485                 490                 495     


Thr Arg Asn Arg Met Asn Arg Ile Leu Leu Ser Cys Phe Asn Trp Tyr 
            500                 505                 510         


Leu Pro Asp Asp Ala Lys Leu Lys Pro Thr Glu Val Asn Lys Leu Ser 
        515                 520                 525             


Ile Tyr Asn Phe Val Ser Asp Asn Ser Tyr Thr Ser Asp Ala Thr Arg 
    530                 535                 540                 


Glu Ser Ile Val Val Gly Ile Gln Gln Lys Leu Asn Arg Ala Gln Phe 
545                 550                 555                 560 


Gly Ala Phe Ala Leu Leu Arg Thr Ala Ser Gly Leu Gln Asp Ala Tyr 
                565                 570                 575     


Leu Lys Met Leu Gly Lys Leu Arg Asp Ser Leu Leu Val Glu Lys Gln 
            580                 585                 590         


Gln Leu Leu Ala Gly Thr His Gly His Val Leu Lys Leu Gly Ala Arg 
        595                 600                 605             


Leu Gly Leu Ala Leu Pro Gly Thr Asp Val Ser Arg Asn Gly Thr Asp 
    610                 615                 620                 


Arg Met Gln Glu Leu Lys Gln Thr Ile Arg Ser Lys Pro Ile Leu Val 
625                 630                 635                 640 


Arg Asn Gly Phe Phe Lys Gln Tyr Phe Met Pro Glu Glu Pro Ala Ala 
                645                 650                 655     


Ala Arg Arg Asn Ser Ile Ser Ala Arg Leu Trp Lys Asn Arg Leu Leu 
            660                 665                 670         


Thr Gln Asn Leu Val Gln Gly Gln Tyr Lys Leu Gln Asn Gln Ser Glu 
        675                 680                 685             


Phe Ile Asn His Pro Glu Tyr Gly Leu Ala Asp Ile Ala Pro Asp Ile 
    690                 695                 700                 


Leu Ala Leu Val Gly Asp His Phe Asp Ala Cys Met Met Glu His Thr 
705                 710                 715                 720 


Gln Gly Ser Arg Gln Thr Phe Ala Gln Leu Val Asp Arg Phe Glu Ala 
                725                 730                 735     


Leu Tyr Thr Gly Ser Lys Ser Pro Glu Lys Arg Lys Gln Ile Ala Asp 
            740                 745                 750         


Ala Ile Asn Tyr Ser Arg Val Leu Lys Glu Ile Gln Ala Gln Asp Ala 
        755                 760                 765             


Leu Leu Leu Gln Val Phe Phe Glu Tyr His Asn Arg Lys Leu Pro Leu 
    770                 775                 780                 


Asn Arg Arg Glu Leu Lys Tyr Lys Pro Leu Ser Thr Leu Phe Glu Glu 
785                 790                 795                 800 


Glu Tyr Glu Leu Gln Ile Asp Ala Ser Tyr Lys Val Gln Leu Lys Tyr 
                805                 810                 815     


Lys Gln Leu Asp Asp Leu Ser Thr His Trp Asn Arg Thr Lys Ile Glu 
            820                 825                 830         


Gln Leu Phe Lys Asn Glu Ala Tyr Trp Asn Leu Ala Ile Ile Ala Glu 
        835                 840                 845             


Leu Asp Ala Lys Gly Lys Lys Ser Met Gln Glu Lys Ile Arg Ile Val 
    850                 855                 860                 


Met Asp Arg Val Trp Asn Asp Ser Tyr His Tyr Ile Lys Ala Phe Leu 
865                 870                 875                 880 


His Ile Glu Lys Glu Ala Val Glu Ile Gln Lys Lys Glu Gly Ile Pro 
                885                 890                 895     


Ala Thr Glu Leu Ile Ser Arg Ser Gln Ala Ile Arg Ser Pro Gly Leu 
            900                 905                 910         


Pro Arg Ile Glu Gly Lys Val Leu Leu Ser Thr Phe Ala Gly Leu Asp 
        915                 920                 925             


Glu Gly Lys Ile Asn Arg Phe Ile Gln Leu Arg Asn Ala Ala Phe His 
    930                 935                 940                 


Ala Gly Ile Pro Glu Glu Cys Val Lys Tyr Glu Lys Val Lys Asp Asp 
945                 950                 955                 960 


Leu Tyr Ala Ala Thr Gly Val Lys Lys Pro Val Val Lys Pro Lys Lys 
                965                 970                 975     


Tyr Glu Lys Lys Lys 
            980     


<210>  1433
<211>  1169
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1433

Met Asp Thr Asn Ala Pro Lys Arg Tyr Thr Met Glu Thr Glu Pro Trp 
1               5                   10                  15      


Tyr Tyr Gly Gly Tyr Leu Asn Met Ala Arg His Asn Met Phe Leu Ile 
            20                  25                  30          


Ser Asn Glu Ile Val Thr Lys Leu Lys Leu Gly Phe Ala Lys Lys Lys 
        35                  40                  45              


Ala Asp Thr Ala Glu Ala Glu Pro Leu Ser Pro Lys Leu Leu Lys Asp 
    50                  55                  60                  


Asp Gly Ala Leu Pro Ser Ser Phe Leu Thr Asp Lys Asp Tyr Leu Glu 
65                  70                  75                  80  


Lys Asn Asn Pro Arg Arg Ile Tyr Ala Leu Leu Arg Arg Phe Leu Pro 
                85                  90                  95      


Leu Ala Ala Leu Phe Ala Thr Asp Thr Thr Ser Asp Glu Tyr Ser Glu 
            100                 105                 110         


Lys Glu Leu Asp Ile Ala Gln Met Ser Asp Ile Leu Lys Glu Leu Phe 
        115                 120                 125             


Ala Glu Leu Asn Arg Phe Arg Asn Asp Tyr Ser His Tyr Tyr Ser Val 
    130                 135                 140                 


Asp Arg Glu Asp Arg Arg Lys Thr Glu Leu Asp Glu Gln Val Ala Val 
145                 150                 155                 160 


Phe Leu Arg Asn Thr Phe Tyr Tyr Ala Ile His Leu Ala Arg Lys Arg 
                165                 170                 175     


Phe Glu Gly Val Ile Asp Ala Arg His Phe Gln Phe Val Glu Lys Glu 
            180                 185                 190         


Ile Ala Pro Gly Ile Val Arg Ala Asp Gly Lys Val Thr Thr Arg Gly 
        195                 200                 205             


Leu Val Phe Phe Cys Cys Leu Phe Leu Asp Lys Glu Asn Ala Phe His 
    210                 215                 220                 


Phe Ile Asn Lys Val Ser Gly Phe Lys Asn Thr Ser Thr Phe Asp Phe 
225                 230                 235                 240 


Leu Ala Thr Arg Glu Val Phe Ser Val Leu Cys Ala Lys Met Pro His 
                245                 250                 255     


Asp Arg Phe Ile Ser Glu Asn Pro Glu Gln Ala Leu Gln Leu Asp Ile 
            260                 265                 270         


Leu Asn Tyr Leu Asn Arg Ala Pro Ala Glu Leu Tyr Gln Ala Leu Ser 
        275                 280                 285             


Ala Glu Ala Lys Lys Pro Phe Gln Pro Gln Leu Gly Lys Asp Glu Arg 
    290                 295                 300                 


Tyr Asn Met Thr Gln Asn Ser Ile Pro Glu His Ile Glu Glu Glu Ser 
305                 310                 315                 320 


Tyr Glu Asn Tyr Leu Glu Ser Ile Ser Val Lys Arg Arg His Thr Asp 
                325                 330                 335     


Arg Phe Pro Glu Phe Ala Leu Lys Phe Leu Asp Arg Ser Asp Thr Phe 
            340                 345                 350         


Asp Phe Tyr Phe Gln Leu His Leu Gly Lys Ser Ile Phe Arg Ala Tyr 
        355                 360                 365             


Pro Lys Thr Leu Leu Gly Glu Thr Pro Glu Glu Pro Asn Arg Ser Ile 
    370                 375                 380                 


Ser Gly Asp Ile Lys Thr Phe Arg Asn Leu His Thr Phe Leu Gly Asn 
385                 390                 395                 400 


His Glu Glu Glu Arg Glu Gln Val Lys Ala Gln Ile Thr Ala Glu Ala 
                405                 410                 415     


Asp Phe Leu Lys Glu Phe Ser Gly Glu Tyr Ala Glu Tyr Phe Thr Gln 
            420                 425                 430         


Tyr Ala Pro His Phe His Ile Val Asn Asn Lys Ile Gly Ile Leu Pro 
        435                 440                 445             


Tyr Ser Asn Lys Lys Tyr His Glu Lys Leu Tyr Arg Pro Leu Ala Pro 
    450                 455                 460                 


Leu Ala Phe Leu Ser Val His Glu Leu Pro Lys Val Ala Leu Leu Glu 
465                 470                 475                 480 


Ile Leu Glu Pro Gly Ser Ala Ala Arg Cys Ile His Glu Cys Ile Gln 
                485                 490                 495     


Lys Ser Thr Ile Gln Val Leu Asn Asn Asp Phe Ile Glu Glu Val Lys 
            500                 505                 510         


Gln Ser Leu Ala Phe Asp Lys Glu Ile Lys Arg Gln Phe Trp Asp Asp 
        515                 520                 525             


Lys Leu Pro His Ile Glu Pro Ala Ala Ala Asp Lys Lys Ala Phe Asp 
    530                 535                 540                 


Asp Ile Arg Asn Lys Leu Asp Gln Glu Lys Lys Gly Arg Asn Arg Gln 
545                 550                 555                 560 


Ser Ala Thr Gln Asn Leu Asn Asn Arg Arg Lys Ala Leu Phe Tyr Ala 
                565                 570                 575     


Gln Tyr Val Ala Arg Val Asn Glu Arg Lys Glu Lys Leu Asn Thr Ile 
            580                 585                 590         


Leu Ala Glu Tyr Gly Leu Asn His Arg Gln Ile Pro Gly Arg Ile Leu 
        595                 600                 605             


Asp Tyr Trp Leu Arg Ile Val Glu Val Glu Thr Ala Ala Ala Ile Lys 
    610                 615                 620                 


Asn Arg Ile Arg Ala Glu Arg Lys Glu Cys Lys Gln Arg Ile Lys Ala 
625                 630                 635                 640 


Leu Asp Ala Gly Lys Gly Pro Lys Ile Gly Glu Met Ala Ser Tyr Leu 
                645                 650                 655     


Ala Arg Asp Ile Val Asn Leu Val Ile Asp Glu Lys Arg Lys Ala Lys 
            660                 665                 670         


Ile Ser Ser Phe Tyr Tyr Asp Gln Leu Gln Glu Cys Leu Ala Leu Tyr 
        675                 680                 685             


Ala Asp Ala Ala Lys Lys Gln Arg Phe Leu Asp Ile Cys Thr Lys Glu 
    690                 695                 700                 


Leu Gln Leu Phe Asp Thr Ala Asn Gly His Pro Phe Leu Ala Asp Leu 
705                 710                 715                 720 


Pro Phe Asn Lys Ile His Lys Thr Lys Asp Leu Tyr Arg Lys Tyr Ile 
                725                 730                 735     


Glu Arg Lys Gly Thr Ala Gln Arg Met Gly Lys Val Trp Asn Arg Lys 
            740                 745                 750         


Glu Lys Cys Phe Lys Ser Glu Lys Lys Glu Asp Ser Trp Leu Cys Asn 
        755                 760                 765             


Thr Phe Tyr Ser Lys Val Lys Ala Lys Asp Lys Thr Glu Ile Gln Ile 
    770                 775                 780                 


Pro Glu Ser Gly Lys Gly Val Pro Leu Ser Tyr Arg Arg Leu Ala Arg 
785                 790                 795                 800 


Glu Glu Ser Pro Leu Pro Ala Trp Leu His Ser Val Thr Lys Gly Asn 
                805                 810                 815     


Val Glu Lys Ala Asp Ser Lys Pro Ile Asp Leu Pro Leu Asn Leu Phe 
            820                 825                 830         


Asp Asp Cys Leu Asn Arg Leu Leu Thr Ala Glu Leu Gly Asp Arg Leu 
        835                 840                 845             


Gln Ala Gly Glu Lys Tyr Asn Tyr Ser Lys Leu Leu Ala Ile Trp Arg 
    850                 855                 860                 


Pro Glu Ile Gln Pro Phe Tyr Asn Trp Glu Arg Glu Tyr Val Leu Phe 
865                 870                 875                 880 


Lys Asp Glu Pro Tyr Glu Gly Arg Val Ala Phe Lys Pro Gly Ala Lys 
                885                 890                 895     


Ala Thr Phe Arg Glu Tyr Tyr Glu Pro Val Leu Asp Ser Val Tyr Arg 
            900                 905                 910         


Lys Arg Lys Arg Val Asp Pro Gln Ile Gln Glu Val Gln Val Arg Arg 
        915                 920                 925             


Val Phe Lys Lys Ala Ile Asp Glu Asn Glu Lys Gln Leu Arg Phe Tyr 
    930                 935                 940                 


Gln Ala Lys Asp Arg Ile Leu Met Leu Met Leu Asp Arg Met Ala Thr 
945                 950                 955                 960 


Glu Lys Leu Asn Ile Ser Leu Ala Glu Ile Tyr Pro Gly Ser Ala Thr 
                965                 970                 975     


Ser Pro Leu Asn Val Gln Thr Thr Ile Ser Glu Lys Ile Gly Asp Lys 
            980                 985                 990         


Tyr Asn Lys Tyr Ile Ser Tyr Thr  Arg Lys Arg Lys Asp  Tyr Ala Leu 
        995                 1000                 1005             


Phe Arg  Arg Phe Ile Thr Asp  Arg Arg Met His Gly  Leu Phe Ala 
    1010                 1015                 1020             


Trp Tyr  Thr Gln Asp Thr Ile  Ala Phe Glu Asp Leu  Lys Lys Glu 
    1025                 1030                 1035             


Leu Asp  Asp Tyr Glu Lys Leu  Arg Pro Gln Val Leu  Glu Met Cys 
    1040                 1045                 1050             


Phe Thr  Leu Glu Gln Ala Ile  Ile Ser His Met Ser  Lys Asp Glu 
    1055                 1060                 1065             


Leu Asp  Ala Met Ala Glu Lys  Ala Asn Ala Lys Ala  Ala Glu Lys 
    1070                 1075                 1080             


Asn Arg  Arg Asn Thr His Val  Glu His Gly Leu Tyr  Met Asp Trp 
    1085                 1090                 1095             


Leu Arg  Lys Tyr Ala Ile Ile  Thr Phe Glu Glu Glu  Thr Phe Tyr 
    1100                 1105                 1110             


Arg Glu  Ile Arg Asn Lys Phe  Ser His Asn Glu Phe  Pro Arg Ala 
    1115                 1120                 1125             


Asp Arg  Leu Pro Lys Ala Val  Arg Glu Ser Ser Asp  Gly Ile Thr 
    1130                 1135                 1140             


Ile Thr  His Ser Ile Val Thr  Tyr Tyr Leu Gln Glu  Leu Gln Lys 
    1145                 1150                 1155             


Leu Met  Glu Glu Lys Gly Val  Phe Thr Ala Leu 
    1160                 1165                 


<210>  1434
<211>  1169
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1434

Met Asp Thr Asn Ala Pro Lys Arg Tyr Thr Met Glu Thr Glu Pro Trp 
1               5                   10                  15      


Tyr Tyr Gly Gly Tyr Leu Asn Met Ala Arg His Asn Met Phe Leu Ile 
            20                  25                  30          


Ser Asn Glu Ile Val Thr Lys Leu Lys Leu Gly Phe Ala Lys Lys Lys 
        35                  40                  45              


Ala Asp Thr Ala Glu Ala Glu Pro Leu Ser Pro Lys Leu Leu Lys Asp 
    50                  55                  60                  


Asp Gly Ala Leu Pro Ser Ser Phe Leu Thr Asp Lys Asp Tyr Leu Glu 
65                  70                  75                  80  


Lys Asn Asn Pro Arg Arg Ile Tyr Ala Leu Leu Arg Arg Phe Leu Pro 
                85                  90                  95      


Leu Ala Ala Leu Phe Ala Thr Asp Thr Thr Ser Asp Glu Tyr Ser Glu 
            100                 105                 110         


Lys Glu Leu Asp Ile Ala Gln Met Ser Asp Ile Leu Lys Glu Leu Phe 
        115                 120                 125             


Ala Glu Leu Asn Arg Phe Arg Asn Asp Tyr Ser His Tyr Tyr Ser Val 
    130                 135                 140                 


Asp Arg Glu Asp Arg Arg Lys Thr Glu Leu Asp Glu Gln Val Ala Val 
145                 150                 155                 160 


Phe Leu Arg Asn Thr Phe Tyr Tyr Ala Ile His Leu Ala Arg Lys Arg 
                165                 170                 175     


Phe Glu Gly Val Ile Asp Ala Arg His Phe Gln Phe Val Glu Lys Glu 
            180                 185                 190         


Ile Ala Pro Gly Ile Val Arg Ala Asp Gly Lys Val Thr Thr Arg Gly 
        195                 200                 205             


Leu Val Phe Phe Cys Cys Leu Phe Leu Asp Lys Glu Asn Ala Phe His 
    210                 215                 220                 


Phe Ile Asn Lys Val Ser Gly Phe Lys Asn Thr Ser Thr Phe Asp Phe 
225                 230                 235                 240 


Leu Ala Thr Arg Glu Val Phe Ser Val Leu Cys Ala Lys Met Pro His 
                245                 250                 255     


Asp Arg Phe Ile Ser Glu Asn Pro Glu Gln Ala Leu Gln Leu Asp Ile 
            260                 265                 270         


Leu Asn Tyr Leu Asn Arg Ala Pro Ala Glu Leu Tyr Gln Ala Leu Ser 
        275                 280                 285             


Ala Glu Ala Lys Lys Pro Phe Gln Pro Gln Leu Gly Lys Asp Glu Arg 
    290                 295                 300                 


Tyr Asn Met Thr Gln Asn Ser Ile Pro Glu His Ile Glu Glu Glu Ser 
305                 310                 315                 320 


Tyr Glu Asn Tyr Leu Glu Ser Ile Ser Val Lys Arg Arg His Thr Asp 
                325                 330                 335     


Arg Phe Pro Glu Phe Ala Leu Lys Phe Leu Asp Arg Ser Asp Thr Phe 
            340                 345                 350         


Asp Phe Tyr Phe Gln Leu His Leu Gly Lys Ser Ile Phe Arg Ala Tyr 
        355                 360                 365             


Pro Lys Thr Leu Leu Gly Glu Thr Pro Glu Glu Pro Asn Arg Ser Ile 
    370                 375                 380                 


Ser Gly Asp Ile Lys Thr Phe Arg Asn Leu His Thr Phe Leu Gly Asn 
385                 390                 395                 400 


His Glu Glu Glu Arg Glu Gln Val Lys Ala Gln Ile Thr Ala Glu Ala 
                405                 410                 415     


Asp Phe Leu Lys Glu Phe Ser Gly Glu Tyr Ala Glu Tyr Phe Thr Gln 
            420                 425                 430         


Tyr Ala Pro His Phe His Ile Val Asn Asn Lys Ile Gly Ile Leu Pro 
        435                 440                 445             


Tyr Ser Asn Lys Lys Tyr His Glu Lys Leu Tyr Arg Pro Leu Ala Pro 
    450                 455                 460                 


Leu Ala Phe Leu Ser Val His Glu Leu Pro Lys Val Ala Leu Leu Glu 
465                 470                 475                 480 


Ile Leu Glu Pro Gly Ser Ala Ala Arg Cys Ile His Glu Cys Ile Gln 
                485                 490                 495     


Lys Ser Thr Ile Gln Val Leu Asn Asn Asp Phe Ile Glu Glu Val Lys 
            500                 505                 510         


Gln Ser Leu Ala Phe Asp Lys Glu Ile Lys Arg Gln Phe Trp Asp Asp 
        515                 520                 525             


Lys Leu Pro His Ile Glu Pro Ala Ala Ala Asp Lys Lys Ala Phe Asp 
    530                 535                 540                 


Asp Ile Arg Asn Lys Leu Asp Gln Glu Lys Lys Gly Arg Asn Arg Gln 
545                 550                 555                 560 


Ser Ala Thr Gln Asn Leu Asn Asn Arg Arg Lys Ala Leu Phe Tyr Ala 
                565                 570                 575     


Gln Tyr Val Ala Arg Val Asn Glu Arg Lys Glu Lys Leu Asn Thr Ile 
            580                 585                 590         


Leu Ala Glu Tyr Gly Leu Asn His Arg Gln Ile Pro Gly Arg Ile Leu 
        595                 600                 605             


Asp Tyr Trp Leu Arg Ile Val Glu Val Glu Thr Ala Ala Ala Ile Lys 
    610                 615                 620                 


Asn Arg Ile Arg Ala Glu Arg Lys Glu Cys Lys Gln Arg Ile Lys Ala 
625                 630                 635                 640 


Leu Asp Ala Gly Lys Gly Pro Lys Ile Gly Glu Met Ala Ser Tyr Leu 
                645                 650                 655     


Ala Arg Asp Ile Val Asn Leu Val Ile Asp Glu Lys Arg Lys Ala Lys 
            660                 665                 670         


Ile Ser Ser Phe Tyr Tyr Asp Gln Leu Gln Glu Cys Leu Ala Leu Tyr 
        675                 680                 685             


Ala Asp Ala Ala Lys Lys Gln Arg Phe Leu Asp Ile Cys Thr Lys Glu 
    690                 695                 700                 


Leu Gln Leu Phe Asp Thr Ala Asn Gly His Pro Phe Leu Ala Asp Leu 
705                 710                 715                 720 


Pro Phe Asn Lys Ile His Lys Thr Lys Asp Leu Tyr Arg Lys Tyr Ile 
                725                 730                 735     


Glu Arg Lys Gly Thr Ala Gln Arg Met Gly Lys Val Trp Asn Arg Lys 
            740                 745                 750         


Glu Lys Cys Phe Lys Ser Glu Lys Lys Glu Asp Ser Trp Leu Cys Asn 
        755                 760                 765             


Thr Phe Tyr Ser Lys Val Lys Ala Lys Asp Lys Thr Glu Ile Gln Ile 
    770                 775                 780                 


Pro Glu Ser Gly Lys Gly Val Pro Leu Ser Tyr Arg Arg Leu Ala Arg 
785                 790                 795                 800 


Glu Glu Ser Pro Leu Pro Ala Trp Leu His Ser Val Thr Lys Gly Asn 
                805                 810                 815     


Val Glu Lys Ala Asp Ser Lys Pro Ile Asp Leu Pro Leu Asn Leu Phe 
            820                 825                 830         


Asp Asp Cys Leu Asn Arg Leu Leu Thr Ala Glu Leu Gly Asp Arg Leu 
        835                 840                 845             


Gln Ala Gly Glu Lys Tyr Asn Tyr Ser Lys Leu Leu Ala Ile Trp Arg 
    850                 855                 860                 


Pro Glu Ile Gln Pro Phe Tyr Asn Trp Glu Arg Glu Tyr Val Leu Phe 
865                 870                 875                 880 


Lys Asp Glu Pro Tyr Glu Gly Arg Val Ala Phe Lys Pro Gly Ala Lys 
                885                 890                 895     


Ala Thr Phe Arg Glu Tyr Tyr Glu Pro Val Leu Asp Ser Val Tyr Arg 
            900                 905                 910         


Lys Arg Lys Arg Val Asp Pro Gln Ile Gln Glu Val Gln Val Arg Arg 
        915                 920                 925             


Val Phe Lys Lys Ala Ile Asp Glu Asn Glu Lys Gln Leu Arg Phe Tyr 
    930                 935                 940                 


Gln Ala Lys Asp Arg Ile Leu Met Leu Met Leu Asp Arg Met Ala Thr 
945                 950                 955                 960 


Glu Lys Leu Asn Ile Ser Leu Ala Glu Ile Tyr Pro Gly Ser Ala Thr 
                965                 970                 975     


Ser Pro Leu Asn Val Gln Thr Thr Ile Ser Glu Lys Ile Gly Asp Lys 
            980                 985                 990         


Tyr Asn Lys Tyr Ile Ser Tyr Thr  Arg Lys Arg Lys Asp  Tyr Ala Leu 
        995                 1000                 1005             


Phe Arg  Arg Phe Ile Thr Asp  Arg Arg Met His Gly  Leu Phe Ala 
    1010                 1015                 1020             


Trp Tyr  Thr Gln Asp Thr Ile  Ala Phe Glu Asp Leu  Lys Lys Glu 
    1025                 1030                 1035             


Leu Asp  Asp Tyr Glu Lys Leu  Arg Pro Gln Val Leu  Glu Met Cys 
    1040                 1045                 1050             


Phe Thr  Leu Glu Gln Ala Ile  Ile Ser His Met Ser  Lys Asp Glu 
    1055                 1060                 1065             


Leu Asp  Ala Met Ala Glu Lys  Ala Asn Ala Lys Ala  Ala Glu Lys 
    1070                 1075                 1080             


Asn Arg  Arg Asn Thr His Val  Glu His Gly Leu Tyr  Met Asp Trp 
    1085                 1090                 1095             


Leu Arg  Lys Tyr Ala Ile Ile  Thr Phe Glu Glu Glu  Thr Phe Tyr 
    1100                 1105                 1110             


Arg Glu  Ile Arg Asn Lys Phe  Ser His Asn Glu Phe  Pro Arg Ala 
    1115                 1120                 1125             


Asp Arg  Leu Pro Lys Ala Val  Arg Glu Ser Ser Asp  Gly Ile Thr 
    1130                 1135                 1140             


Ile Thr  His Ser Ile Val Thr  Tyr Tyr Leu Gln Glu  Leu Gln Lys 
    1145                 1150                 1155             


Leu Met  Glu Glu Lys Gly Val  Phe Thr Ala Leu 
    1160                 1165                 


<210>  1435
<211>  981
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1435

Met Ala Asp Lys Thr Ala Glu Leu Cys Leu Phe Tyr Asn Leu Ala Leu 
1               5                   10                  15      


Asn Arg Val Asn Asp Leu Val Arg Lys Tyr Glu Lys Asp Asp Thr Leu 
            20                  25                  30          


His Ile Glu Asp Val Asn Trp Glu Thr Phe Gly Gly Phe Arg Asn Val 
        35                  40                  45              


Ser Thr Tyr Leu His Leu Gln Val Phe Met Trp Lys Glu Pro Leu Ser 
    50                  55                  60                  


Ala Ser Phe Thr Thr Leu Ser Thr Ala Asp Lys Lys Arg Ile His Glu 
65                  70                  75                  80  


Leu Leu Arg Lys Leu Val Asp Leu Arg Asn Tyr Gln Ser His Tyr Tyr 
                85                  90                  95      


His Asp Ala Ser Val Leu Lys Phe Pro Gln Glu Leu Ile Asp Phe Ile 
            100                 105                 110         


Tyr Ser Arg Tyr Ala Asn Ala Arg Asn Ala Leu Glu Leu Lys Tyr Pro 
        115                 120                 125             


Glu Phe Val Thr Trp Phe His Asp Leu Asn Glu Asp Lys Val Ile Phe 
    130                 135                 140                 


Lys Asn Ser Lys Gly Glu Glu Arg Glu Asp Val Tyr Arg His Phe Tyr 
145                 150                 155                 160 


Phe Phe Asn Ala Asn Gly Asn Ile Glu Pro Glu Gly Lys Asn Phe Phe 
                165                 170                 175     


Leu Ser Phe Phe Leu Leu Lys Gly Glu Met Ser Lys Phe Leu Lys Lys 
            180                 185                 190         


Arg Ser Arg Cys Lys Arg Asp Asn Gly Glu Lys Tyr Gln Val Lys Thr 
        195                 200                 205             


Arg Leu Tyr Thr Tyr Tyr Cys His Arg Asp Gly Ser Asn Arg Phe Phe 
    210                 215                 220                 


Leu Glu Gly Lys Glu Glu Tyr Met Asp Thr Glu Glu Arg Leu Arg Arg 
225                 230                 235                 240 


Gln Gly Asn Thr Leu Leu Asn Tyr Leu Lys Ser Arg Pro Leu Val Asp 
                245                 250                 255     


Leu Lys Tyr Leu Pro Pro Ala Pro Pro Pro Gln Leu Leu Ser Lys Lys 
            260                 265                 270         


Glu Val Glu Glu Arg Lys Asn Arg Ala Glu Ser Gln Ala Glu Glu Glu 
        275                 280                 285             


Lys Thr Tyr Ile Arg Arg Thr Asp Lys Phe Ala Ser Leu Val Val Arg 
    290                 295                 300                 


Tyr Phe Met Asp Arg Ala Phe Leu Gly Tyr Glu Gln Glu Pro Cys Phe 
305                 310                 315                 320 


Tyr Trp His Val Lys Ser Leu Asp Leu Glu Glu Val Gln Lys Gln Lys 
                325                 330                 335     


Gln Glu Asn Arg Val Tyr Asp Ala Glu Gly Ala Tyr Tyr Tyr Gln Lys 
            340                 345                 350         


Glu Ser Arg Trp Ser Pro His Phe Val Pro Gly Glu Phe Pro Val Phe 
        355                 360                 365             


Val Asn Gly His Ile Lys Phe Arg Leu Gly Pro Glu Gly Met Glu Tyr 
    370                 375                 380                 


Ala Ile Ser Thr Gly Glu Leu Lys Asn Met Leu Tyr Leu Leu Leu Asn 
385                 390                 395                 400 


Ser Pro Arg Lys Asn Met Thr Glu Ile Gln Asp Ala Leu Leu Arg Tyr 
                405                 410                 415     


Gly Thr Gln Phe Ser Asn Ala Met Arg Glu Leu Thr Thr Glu His Asn 
            420                 425                 430         


Ile Arg Tyr Glu Ala Tyr Pro Leu Val Phe Glu Lys Gly Arg Asp Ser 
        435                 440                 445             


Val Leu Leu Ser Lys Met His Arg Lys Val Leu Asp Lys Glu Lys Phe 
    450                 455                 460                 


Asp Ala Ala Ile Tyr Thr Ala Ala Leu Glu Lys Ala Leu Asp Ser Arg 
465                 470                 475                 480 


Leu Arg Trp Val Glu Tyr Asn Cys Lys Pro Glu Val Tyr Thr Leu Tyr 
                485                 490                 495     


Thr Arg Asn Arg Met Asn Arg Ile Leu Leu Ser Cys Phe Asn Trp Tyr 
            500                 505                 510         


Leu Pro Asp Asp Ala Lys Leu Lys Pro Thr Glu Val Asn Lys Leu Ser 
        515                 520                 525             


Ile Tyr Asn Phe Val Ser Asp Asn Ser Tyr Thr Ser Asp Ala Thr Arg 
    530                 535                 540                 


Glu Ser Ile Val Val Gly Ile Gln Gln Lys Leu Asn Arg Ala Gln Phe 
545                 550                 555                 560 


Gly Ala Phe Ala Leu Leu Arg Thr Ala Ser Gly Leu Gln Asp Ala Tyr 
                565                 570                 575     


Leu Lys Met Leu Gly Lys Leu Arg Asp Ser Leu Leu Val Glu Lys Gln 
            580                 585                 590         


Gln Leu Leu Ala Gly Thr His Gly His Val Leu Lys Leu Gly Ala Arg 
        595                 600                 605             


Leu Gly Leu Ala Leu Pro Gly Thr Asp Val Ser Arg Asn Gly Thr Asp 
    610                 615                 620                 


Arg Met Gln Glu Leu Lys Gln Thr Ile Arg Ser Lys Pro Ile Leu Val 
625                 630                 635                 640 


Arg Asn Gly Phe Phe Lys Gln Tyr Phe Met Pro Glu Glu Pro Ala Ala 
                645                 650                 655     


Ala Arg Arg Asn Ser Ile Ser Ala Arg Leu Trp Lys Asn Arg Leu Leu 
            660                 665                 670         


Thr Gln Asn Leu Val Gln Gly Gln Tyr Lys Leu Gln Asn Gln Ser Glu 
        675                 680                 685             


Phe Ile Asn His Pro Glu Tyr Gly Leu Ala Asp Ile Ala Pro Asp Ile 
    690                 695                 700                 


Leu Ala Leu Val Gly Asp His Phe Asp Ala Cys Met Met Glu His Thr 
705                 710                 715                 720 


Gln Gly Ser Arg Gln Thr Phe Ala Gln Leu Val Asp Arg Phe Glu Ala 
                725                 730                 735     


Leu Tyr Thr Gly Ser Lys Ser Pro Glu Lys Arg Lys Gln Ile Ala Asp 
            740                 745                 750         


Ala Ile Asn Tyr Ser Arg Val Leu Lys Glu Ile Gln Ala Gln Asp Ala 
        755                 760                 765             


Leu Leu Leu Gln Val Phe Phe Glu Tyr His Asn Arg Lys Leu Pro Leu 
    770                 775                 780                 


Asn Arg Arg Glu Leu Lys Tyr Lys Pro Leu Ser Thr Leu Phe Glu Glu 
785                 790                 795                 800 


Glu Tyr Glu Leu Gln Ile Asp Ala Ser Tyr Lys Val Gln Leu Lys Tyr 
                805                 810                 815     


Lys Gln Leu Asp Asp Leu Ser Thr His Trp Asn Arg Thr Lys Ile Glu 
            820                 825                 830         


Gln Leu Phe Lys Asn Glu Ala Tyr Trp Asn Leu Ala Ile Ile Ala Glu 
        835                 840                 845             


Leu Asp Ala Lys Gly Lys Lys Ser Met Gln Glu Lys Ile Arg Ile Val 
    850                 855                 860                 


Met Asp Arg Val Trp Asn Asp Ser Tyr His Tyr Ile Lys Ala Phe Leu 
865                 870                 875                 880 


His Ile Glu Lys Glu Ala Val Glu Ile Gln Lys Lys Glu Gly Ile Pro 
                885                 890                 895     


Ala Thr Glu Leu Ile Ser Arg Ser Gln Ala Ile Arg Ser Pro Gly Leu 
            900                 905                 910         


Pro Arg Ile Glu Gly Lys Val Leu Leu Ser Thr Phe Ala Gly Leu Asp 
        915                 920                 925             


Glu Gly Lys Ile Asn Arg Phe Ile Gln Leu Arg Asn Ala Ala Phe His 
    930                 935                 940                 


Ala Gly Ile Pro Glu Glu Cys Val Lys Tyr Glu Lys Val Lys Asp Asp 
945                 950                 955                 960 


Leu Tyr Ala Ala Thr Gly Val Lys Lys Pro Val Val Lys Pro Lys Lys 
                965                 970                 975     


Tyr Glu Lys Lys Lys 
            980     


<210>  1436
<211>  1128
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1436

Met Glu Ile Leu Thr Ile Pro Glu Val Ile Lys Cys Arg Thr Leu Ser 
1               5                   10                  15      


Asp Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Val Leu Asn Ile Ser Asn His Ile Ala Lys Glu Phe Lys Leu Pro Leu 
        35                  40                  45              


Leu Pro Glu Glu Ala His Leu Lys Asn Ser Phe Leu Cys Lys Lys Glu 
    50                  55                  60                  


Asn Lys Lys Ile Asp Trp Asn His Val Tyr Ala Arg Thr Ile Arg Phe 
65                  70                  75                  80  


Leu Ser Val Met Lys Val Phe Asp Ala Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Lys Thr Ile Asp Trp Glu Gly Lys Asp Phe Ala Ser Met Cys Asp 
            100                 105                 110         


Thr Leu Asn Ile Val Phe Ser Glu Leu Gln Glu Phe Ser Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Glu Thr Lys Arg Lys Thr Thr Val 
    130                 135                 140                 


Ser Asp Glu Leu Ala Leu Phe Leu Arg Thr Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Glu Tyr Thr Lys Val Arg Phe Lys Gly Ile Leu Asn Asp Glu Asp Tyr 
                165                 170                 175     


Gln Leu Val Val Ser Lys Lys Met Leu Glu Thr Asn His Thr Ile Thr 
            180                 185                 190         


His Glu Gly Leu Val Phe Leu Thr Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Arg Phe Ile Arg Lys Ile His Gly Leu Ser Gly Pro Lys Asp 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Cys Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro Gln Glu Gln Phe Arg Ser Asp Asn Arg Arg Gln Ala Ile Ser 
                245                 250                 255     


Leu Glu Leu Met Asn Glu Leu Lys Lys Cys Pro Lys Val Leu Tyr His 
            260                 265                 270         


Val Ile Thr Glu Glu Trp Lys Gln Lys Leu Lys Ser Val Pro Glu Glu 
        275                 280                 285             


Leu Glu Thr Lys Asn Leu His Tyr Asn Thr Lys Arg Glu Thr Lys Ile 
    290                 295                 300                 


Glu Phe Glu Asp Tyr Asp Leu Tyr Ile Glu Ser Leu Thr Lys Gln Val 
305                 310                 315                 320 


Arg Tyr Asn Asn Arg Phe Ser Glu Phe Ala Leu Lys Tyr Ile Asp Glu 
                325                 330                 335     


Thr Gly Ile Phe Ser Glu Phe Arg Phe Gln Leu Asp Leu Gly Lys Ile 
            340                 345                 350         


Leu Val Asp Glu Tyr Leu Lys Asn Phe Asn Asp Glu Arg Val Gln Arg 
        355                 360                 365             


Cys Ile Ile Glu Asn Ala Lys Ala Phe Gly Lys Leu Asn Asp Tyr Thr 
    370                 375                 380                 


Asn Glu Thr Lys Val Met Ser Leu Ile Val Asn Gly Pro Pro Leu Lys 
385                 390                 395                 400 


Ser Phe Asp Arg Phe Ala Pro His Tyr Asn Ile Glu Ser Asn Lys Ile 
                405                 410                 415     


Gly Ile Ser Thr His Glu Val Thr Ala Lys Leu Val Pro Asn Ser Lys 
            420                 425                 430         


Gly Glu Pro Ala Lys Lys Leu His Gln Pro Leu Pro Glu Ala Phe Leu 
        435                 440                 445             


Ser Leu His Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu Gln Lys 
    450                 455                 460                 


Gly Glu Pro Glu Lys Leu Ile Asn Glu Phe Ile Leu Val Asn Asn Ser 
465                 470                 475                 480 


Lys Leu Met Asn Met Ser Phe Ile Glu Glu Val Lys Asn Gln Leu Pro 
                485                 490                 495     


Lys Glu Trp Asp Lys Phe Gln Arg Arg Thr Asn Ala Lys His Glu Leu 
            500                 505                 510         


Ala Tyr Asp Glu Asn Thr Leu Ala Phe Leu Leu Gln Arg Lys Gln Ile 
        515                 520                 525             


Leu Asn Lys Thr Leu Leu Ala Tyr Gln Leu Asn Asp Lys Gln Ile Pro 
    530                 535                 540                 


Thr Arg Ile Leu Asp Tyr Trp Leu Asn Ile Ser Asp Ala Asp Glu Glu 
545                 550                 555                 560 


Arg Ala Ile Ser Asn Arg Leu Lys Ser Ile Lys Arg Asp Cys Met Ser 
                565                 570                 575     


Arg Leu Lys Ala Leu Ser Lys Phe Asn Glu Asn Gly Asn Arg Asn Lys 
            580                 585                 590         


Ile Pro Gly Ile Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile Ile 
        595                 600                 605             


Glu Met Val Val Ser Glu Gly Lys Lys Arg Lys Ile Thr Ser Phe Tyr 
    610                 615                 620                 


Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Gly Asp Pro Asp Lys 
625                 630                 635                 640 


Lys Gln Leu Phe Ile His Ile Val Thr Lys Glu Leu Lys Leu Asn Asp 
                645                 650                 655     


Pro Gly Gly His Pro Phe Leu Asp Lys Leu Asp Leu Gln Lys Ile Asn 
            660                 665                 670         


Ser Thr Thr Gly Phe Tyr Glu Ile Tyr Leu Gln Glu Lys Gly His Lys 
        675                 680                 685             


Met Val Pro Glu Asn Asn Pro Lys Thr Gly Lys Val Ile Tyr Thr Asp 
    690                 695                 700                 


His Ser Trp Met Ala Leu Thr Phe Tyr Lys Ile Glu Phe Asn Asp Lys 
705                 710                 715                 720 


Val Asp Met Leu Met Thr Val Val Lys Leu Pro Leu Lys Lys Leu Asn 
                725                 730                 735     


Ile Pro Phe Thr Leu Arg Gln Leu Ser Gly Lys Thr Asn Asn Thr Leu 
            740                 745                 750         


Lys Gln Trp Leu Asn Asn Leu Thr Gln Gly Lys Lys Arg Asn Asp Gly 
        755                 760                 765             


Lys Arg Pro Ile Asn Leu Pro Thr Asn Leu Phe Asp Glu Arg Leu Ala 
    770                 775                 780                 


Glu Leu Leu Arg Lys Asp Leu Asp Asn Lys Lys Ile Val Tyr Trp Pro 
785                 790                 795                 800 


Tyr Ala Asn Trp Asn Glu Leu Phe Lys Thr Trp Trp Ser Ser Arg Asn 
                805                 810                 815     


Asp Gly Leu Gln Ser Phe Tyr Asn Ala Glu Arg Glu Tyr Arg Ile Phe 
            820                 825                 830         


Asp Glu Lys Val Asn Phe Tyr Pro Asn Arg Lys Glu Asn Phe Ala Asp 
        835                 840                 845             


Tyr Tyr Gln His Ala Leu Lys Leu Ala Phe Gln Lys Lys Gln Ser Lys 
    850                 855                 860                 


Arg Ile Leu Glu Gln Met Tyr Asp Gln His Leu Pro Asp Ile Leu Phe 
865                 870                 875                 880 


Asp Gln Val Glu Lys Thr Phe Arg His Thr Ile Ala Glu Thr Glu Lys 
                885                 890                 895     


Glu Ile Arg Ile Leu Gln Glu Glu Asp His Ile Met Leu Leu Met Leu 
            900                 905                 910         


Glu Ser Leu Leu Asp Asp Gly Ser Lys Gln Gln Leu Lys Leu Ser Glu 
        915                 920                 925             


Ile Arg Thr His Leu Asn Arg Thr Thr Asn Ile Arg Gln Val Val Lys 
    930                 935                 940                 


Gly Lys Leu Ser Phe Asp Asp Ser Gly Glu Leu Ile Lys Asp Asn Thr 
945                 950                 955                 960 


Asn Ser Glu Ile Val Arg Thr Val Ser Val Thr Asp Gln Leu Lys Lys 
                965                 970                 975     


Phe His Leu Arg Pro Arg Phe Ile Ser Asp Ser Arg Leu Pro Glu Leu 
            980                 985                 990         


Phe Glu Tyr Phe Pro Asp Lys Glu  Ile Gln Met Glu Ser  Leu Lys Asn 
        995                 1000                 1005             


Glu Phe  Asp Thr Tyr Asn Ala  Ala Arg Gln Val Val  Leu Asn Leu 
    1010                 1015                 1020             


Ser Phe  Asn Leu Glu Lys Met  Ile Ile Glu Lys Gly  Arg Leu Asp 
    1025                 1030                 1035             


Arg Ile  Asn Gln Leu Leu Thr  Ser Ala Thr Gly Asp  Leu Leu Thr 
    1040                 1045                 1050             


Gly His  Ile Gly His Lys Thr  Tyr Leu Thr Trp Leu  Lys Asn His 
    1055                 1060                 1065             


Gly Ile  Ile Asp Asn Asp Thr  Phe Ile Phe Met Asn  Met Val Gln 
    1070                 1075                 1080             


Tyr Cys  Phe Ser His Asn Gln  Tyr Pro Gln Lys Lys  Thr Met Ala 
    1085                 1090                 1095             


Arg Leu  Ile Ser Arg Trp Asp  Gln His Arg Phe Ala  Leu Gln Ile 
    1100                 1105                 1110             


Glu Ala  Thr Tyr Ile Gln Lys  Ile Ala Gly Ile Ile  Glu Asp Leu 
    1115                 1120                 1125             


<210>  1437
<211>  1140
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1437

Met Glu Asn Asp Gln Gln Ile Leu Glu Asn Arg Arg Arg Thr Leu Ala 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Ser Asn His Leu Ala Thr Ser Phe Glu Gln Lys Ala 
        35                  40                  45              


Leu His Glu Glu Gly Gln Ile Pro Ala Ser Phe Leu Cys Asn Lys Ser 
    50                  55                  60                  


Ile Lys Lys Ile Asn Trp Asn His Val Tyr Ser Lys Ala Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Ile Phe Asp Ala Asp Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Arg Glu Thr Ser Asp Lys Glu Gly Lys Asp Phe Thr Ala Met Asn Glu 
            100                 105                 110         


Thr Leu Lys Leu Val Phe Asp Glu Leu Gln Ala Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Ala Asp Ser Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Val Glu Leu Ala Asp Phe Leu Thr Val Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Ala Asp Asp Asp Tyr 
                165                 170                 175     


Ala Val Val Glu Ser Lys Gln Ile Val Thr Pro Asp Asn Gln Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Ile Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Val Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Leu Ala Tyr Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asp Leu Arg Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Glu 
            260                 265                 270         


Val Ile Thr Glu Glu Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Glu Glu Glu Arg 
    290                 295                 300                 


Glu Lys Ile Leu Asp Glu Ile Asp Tyr Glu Asp Tyr Ile Glu Ser Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg His Ser Asn Arg Phe Pro Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Glu Lys Tyr Asn Lys Gln Phe Asp Gly Glu 
        355                 360                 365             


Ala Thr Glu Arg Lys Val Val Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asn Gln Glu Thr Val Glu Leu Lys Ile Asp Ser Ala 
385                 390                 395                 400 


Gln Arg Thr Asn Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Glu Ala Arg Leu Leu 
            420                 425                 430         


Thr Lys Ala Lys Pro Glu Ser Lys Val Ser Tyr Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Lys Ala Glu Glu Met Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Lys Val Asn Asp Ser Gln Leu Met Asn Met Gln Phe Ile Asp Glu 
                485                 490                 495     


Ile Lys Glu Gln Leu Pro Ala Asp Trp Asn Glu Phe Gly Lys Arg Ser 
            500                 505                 510         


Asp Ser Lys Lys Lys Lys Ala Tyr Thr Asn Ala Ala Arg Gln Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Lys Val Leu Ala Asn Tyr Gln Leu 
    530                 535                 540                 


Asn Asp Lys Gln Val Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Val 
545                 550                 555                 560 


Lys Glu Val Asp Asp Ser Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Met Glu Lys His Lys Val 
            580                 585                 590         


Asp Lys Ser Ala Arg Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Thr Asp Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Tyr 
625                 630                 635                 640 


Ala Asp Asn Glu Lys Lys Ala Thr Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Lys Asp Gly His Pro Phe Leu Ala Asn Ile Asn 
            660                 665                 670         


Leu Arg Gln Ile Arg Lys Thr Ser Gln Leu Tyr Glu Leu Tyr Leu Val 
        675                 680                 685             


Glu Lys Ala Asn Lys Gln Val Lys Lys Met Asn Pro Lys Thr Gln Arg 
    690                 695                 700                 


Thr Asn Asn Val Asp Glu Ser Trp Met Met Lys Ser Phe Tyr Ala Lys 
705                 710                 715                 720 


Glu Trp Asn Glu Glu Met Gly Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Thr Asn Ile Pro Phe Thr Ile Arg Gln Trp Glu Glu Lys 
            740                 745                 750         


Glu Lys His Asn Leu Gln Ala Trp Leu His Asn Ile Thr Lys Gly Lys 
        755                 760                 765             


Thr Ser Lys Asp Gly Lys Lys Ala Val Asp Leu Pro Thr Asn Leu Phe 
    770                 775                 780                 


Asp Asp Thr Leu Cys Glu Leu Leu Arg Glu Ala Leu Ile Asn Glu Gly 
785                 790                 795                 800 


Ile Asp Ala Thr Pro Thr Thr Lys Tyr Asn Glu Leu Leu Lys His Trp 
                805                 810                 815     


Trp Thr Ala Arg Glu Asp Ser Thr Gln Asp Phe Tyr Leu Ser Glu Arg 
            820                 825                 830         


Gln Tyr Asp Ile Tyr Asp Glu Lys Val Cys Phe Thr Ile Asn Ser Ser 
        835                 840                 845             


Ala His Phe Ala Asp Tyr Tyr Ala Pro Ala Leu Ser Lys Ala Tyr Ser 
    850                 855                 860                 


Arg Leu Arg Ala Glu Arg Asp Val Ala Arg Arg Thr Asp Lys Arg Leu 
865                 870                 875                 880 


Pro Pro Val Glu Arg Lys Asp Val Glu Arg Val Phe Lys Asn Thr Ile 
                885                 890                 895     


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
            900                 905                 910         


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asn Gln Gln Gln Leu Lys 
        915                 920                 925             


Leu Ser Lys Met Asp Ser Leu Leu Asn Glu Thr Lys Arg Ile Glu Gln 
    930                 935                 940                 


Val Ile Asn Thr Gln Leu Ser Phe Asp Gln Lys Gly Lys Glu Ile Lys 
945                 950                 955                 960 


Asp Lys Thr Asn Leu Glu Ile Val Lys Thr Ile Val Ala Glu Arg Lys 
                965                 970                 975     


Gln Lys Asn Tyr Thr Glu Met Arg Lys Tyr Val His Asp Arg Arg Leu 
            980                 985                 990         


Pro Glu Leu Phe Glu Tyr Ile Asp  Gly Asn Glu Leu Pro  Leu Asp Met 
        995                 1000                 1005             


Leu Leu  Asn Glu Leu Arg Ala  Tyr Asn Thr Ala Lys  Gln Val Val 
    1010                 1015                 1020             


Phe Asp  Thr Val Phe Ala Leu  Glu Lys Lys Ile Ile  Glu Thr Asp 
    1025                 1030                 1035             


Pro Glu  Gly Leu Lys Gln Leu  Asn Val Ser Lys Asp  Gly Gln Ile 
    1040                 1045                 1050             


Gln Thr  Gly Asn Ile Gln His  Lys Pro Tyr Val Gln  Trp Leu Glu 
    1055                 1060                 1065             


Asn Lys  Gly Leu Ile Thr Asp  Lys Asp Lys Gln Phe  Ile Asn Met 
    1070                 1075                 1080             


Val Arg  Asn Ser Phe Ser His  Asn Gln Phe Pro Gln  Arg Ser Thr 
    1085                 1090                 1095             


Val Glu  Leu Leu Met Pro Val  Trp Gln Asn Thr Asn  Ile Ala Leu 
    1100                 1105                 1110             


Gln Ile  Ala Arg Glu Tyr Gln  Gln Leu Ile Val Asp  Ile Ile Glu 
    1115                 1120                 1125             


Lys Ser  Leu His Pro His Lys  Gln His Gln Met Val  
    1130                 1135                 1140 


<210>  1438
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1438

Met Glu Thr Lys Gln Gln Val Gly Lys Gly Ile Ser Tyr Asp His Arg 
1               5                   10                  15      


Arg Pro Asp Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asp Gly Val Ile Gln Glu Phe Ala Met Arg Leu Asn Arg 
        35                  40                  45              


Glu Tyr Asp Pro Glu Asn Lys Asn Gln Ser Leu Phe Ser Tyr Phe Asn 
    50                  55                  60                  


Ile Asn Ala Ser Phe Thr Asp Trp Glu Arg Gly Val Asn Ile Leu Lys 
65                  70                  75                  80  


Glu Tyr Trp Pro Met Met Glu Phe Ile Asp Arg Pro Ala Thr Asp Lys 
                85                  90                  95      


Gln Phe Glu Ala Glu Lys Pro Glu Asn Arg Glu Ala Ala Lys Arg Lys 
            100                 105                 110         


Tyr Phe Leu Ala Thr Leu Gly Ala Leu Leu Thr Ser Ile Lys Asp Leu 
        115                 120                 125             


Arg His Tyr Tyr Thr His Tyr Tyr His Pro Pro Val His Leu Asn Asp 
    130                 135                 140                 


Asp Leu Phe Leu Phe Leu Asp His Ala Leu Leu Tyr Thr Ala Phe Asp 
145                 150                 155                 160 


Val Lys Lys Thr Lys Met Lys Asp Asp Lys Thr Arg Gln Leu Leu Asn 
                165                 170                 175     


Gln Asn Leu Ser Leu Glu Leu Glu Lys Leu Lys Lys Leu Lys Val Glu 
            180                 185                 190         


Glu Leu Lys Lys Lys Lys Glu Lys Gly Ile Lys Val Asn Leu Gln Asp 
        195                 200                 205             


Glu Lys Gly Ile Leu Asn Ala Ile Tyr Asn Asp Ala Phe Ala His Ile 
    210                 215                 220                 


Ile Thr Lys Glu Lys Asp Ser Asp Lys Asp Lys Leu Glu Thr Arg Tyr 
225                 230                 235                 240 


Lys Ser Ile Leu Pro Gln Asp Glu Ala Ala Glu Thr Gly Ile Asn Ile 
                245                 250                 255     


Ser Ile Ser Gly Leu Ile Phe Leu Leu Ser Leu Phe Leu Ser Arg Lys 
            260                 265                 270         


Glu Ile Glu Gln Leu Lys Ser Asn Ile Glu Gly Tyr Lys Gly Lys Val 
        275                 280                 285             


Leu Asn Ile Glu Thr Glu Val Asp Arg Lys His Asn Ser Leu Lys Tyr 
    290                 295                 300                 


Met Ala Thr His Trp Val Phe Ser Ile Leu Ala Phe Lys Gly Leu Lys 
305                 310                 315                 320 


Gln Arg Leu Thr Asn Ser Phe Glu Lys Glu Ser Leu Leu Ile Gln Met 
                325                 330                 335     


Met Asp Glu Leu Asn Lys Val Pro Asp Glu Leu Tyr Gln Thr Leu Ser 
            340                 345                 350         


Glu Thr Ala Lys Lys Glu Phe Leu Glu Asp Ile Asn Glu Tyr Val Ser 
        355                 360                 365             


Glu Gly Asp Asp Asn Glu Lys Ala Thr Tyr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Ser Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gln Phe Pro Thr Leu Lys Phe Gln Ile Phe Val Gly 
                405                 410                 415     


Gln Tyr Leu His Asp Asn Arg Pro Lys Thr Leu Ala Ser Asn Gly Met 
            420                 425                 430         


Thr Ala Gln Arg Met Ile Lys Glu Lys Ile Asn Leu Phe Gly Asn Leu 
        435                 440                 445             


Ser Glu Val Thr Lys His Lys Ser Asp Phe Phe Glu Lys Glu Ser Ala 
    450                 455                 460                 


Ala Gln Gly Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Trp Ala Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Val Tyr Ile Asp Met Ile Gly Lys Glu Gly Lys Ala 
                485                 490                 495     


Lys Glu Ile Gln Val Gln Ile Asn Lys Tyr Arg Lys Gln Leu Asn Pro 
            500                 505                 510         


Ala Pro Gln Arg Asp Lys Arg Ile Ser Lys Lys Glu Ile Ile Glu Gln 
        515                 520                 525             


Leu Tyr Lys Glu Lys Val Val Tyr Gly Asp Pro Thr Leu Met Leu Ser 
    530                 535                 540                 


Ala Asn Glu Leu Met Ala Leu Leu Tyr Glu Leu Ile Val Asn Gly Lys 
545                 550                 555                 560 


Ser Gly Ala Glu Leu Glu Asn Lys Ile Val Glu Gln Ile Ile Ala Arg 
                565                 570                 575     


Tyr Glu Gln Ile Glu Ala Tyr Asp Pro Thr Thr Gln Gln Leu Pro Thr 
            580                 585                 590         


Asn Gln Met Pro His Lys Leu Gln Lys Ser Arg Lys Asp Ser Lys Val 
        595                 600                 605             


Thr Asp Thr Asp Lys Leu Leu Lys Thr Ile Asp Lys Glu Ile Asp Glu 
    610                 615                 620                 


Gly Asn Lys Lys Leu Glu Leu Ile Ala Cys His Arg Lys Glu Trp Glu 
625                 630                 635                 640 


Glu Ala Glu Gln Arg Lys Lys Ser Gly Lys Arg Asn Asn Pro Gly Thr 
                645                 650                 655     


Lys Ser Arg Lys His Leu Phe Tyr Ala Ser Glu Met Gly Glu Glu Ala 
            660                 665                 670         


Thr Trp Ile Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Pro Ala Arg 
        675                 680                 685             


Ala Glu Trp Lys Gly Thr His His Ser Glu Leu Gln Arg Leu Leu Ala 
    690                 695                 700                 


Phe Tyr Ser Thr Gln Arg Leu Glu Ala Trp Gln Leu Val Glu Ser Val 
705                 710                 715                 720 


Trp Thr Ala Asn Thr His Ser Phe Trp Glu Glu Asn Phe Lys Glu Ala 
                725                 730                 735     


Phe Tyr Lys Pro Glu Phe Glu Asn Phe Tyr Gly Ala Tyr Ile Glu Ile 
            740                 745                 750         


Arg Thr Lys Ile Leu Thr Thr Cys Arg Ser Ile Leu Glu Asn Asn Pro 
        755                 760                 765             


Glu Ala Thr Met Asn Asn Asp Thr Glu Lys Glu Trp Asp Lys Val Phe 
    770                 775                 780                 


Thr Leu Phe Asp Lys Arg Leu Tyr Arg Thr Ser Thr Thr Asp Glu Gln 
785                 790                 795                 800 


Lys Lys Gln Leu Leu Thr Lys Pro Phe Ala Phe Pro Arg Gly Leu Phe 
                805                 810                 815     


Asp Asp Lys Pro Thr Phe Leu Pro Gly Ser Lys Pro Asn Glu Asn Pro 
            820                 825                 830         


Glu Arg Phe Ala Ala Trp Tyr Ser Tyr Gly Tyr Thr Tyr Ser Gly Lys 
        835                 840                 845             


Phe Gln Ser Phe Tyr Asp Met Pro Arg Asn Tyr Ser Asp Trp Tyr Lys 
    850                 855                 860                 


Lys Leu Lys Glu Asp Gly Lys Leu Pro Arg Leu Asp Lys Lys Thr Glu 
865                 870                 875                 880 


Gln Glu Lys Ile Leu Arg Phe Arg Met Asp Cys Asp Leu Asn Ile Lys 
                885                 890                 895     


His Ile Arg Phe Gln Asp Ile Tyr Val Lys Leu Met Val Asp Ser Leu 
            900                 905                 910         


Tyr Lys Ala Val Phe Gly Gln Gln Pro Glu Phe Asp Leu Ser His Leu 
        915                 920                 925             


Tyr Asp Thr Arg Ser Glu Arg Tyr Glu Asn Asn Thr Ile Ala Gln Arg 
    930                 935                 940                 


Gln Lys Ser Arg Gln Glu Gly Asp Asn Ser Asp Asn Ala Ile Asn Glu 
945                 950                 955                 960 


Asn Tyr Val Trp Asn Lys Thr Phe Ala Ile Ser Leu Tyr Asn Gly Arg 
                965                 970                 975     


Ile Thr Glu Ser Gln Val Lys Leu Lys Asp Val Gly Lys Phe Arg Arg 
            980                 985                 990         


Phe Ala Thr Asp Pro Arg Val Gln  Thr Leu Ile Ser Tyr  Asp Asp Thr 
        995                 1000                 1005             


Arg Thr  Trp Thr Lys Leu Glu  Ile Glu Asn Glu Leu  Asp Asn Lys 
    1010                 1015                 1020             


Ala Asp  Ala Tyr Glu Pro Ile  Arg Arg Thr Gln Ser  Leu Lys Ala 
    1025                 1030                 1035             


Ile Gln  Gln Leu Glu Lys Asn  Ile Leu Lys Lys Asn  Gly Phe Asn 
    1040                 1045                 1050             


Gly Lys  Gln His Pro Glu Glu  Leu Lys His Asn Gly  Asn Pro Asn 
    1055                 1060                 1065             


Phe Arg  Lys Tyr Ile Ala Asn  Gly Leu Leu Lys His  Arg Thr Asp 
    1070                 1075                 1080             


Ile Arg  Gln Glu Glu Leu Ala  Leu Ile Ser Asp Thr  Glu Phe Gln 
    1085                 1090                 1095             


Glu Ile  Gly Leu Glu Arg Ile  Arg Gln Thr Asn Pro  Leu Ile Gln 
    1100                 1105                 1110             


Lys Ala  Tyr Leu Leu Ile Leu  Leu Arg Asn Lys Phe  Gly His Asn 
    1115                 1120                 1125             


Gln Leu  Pro Asp Gln Glu His  Phe Arg Leu Met Arg  Ser Ile Tyr 
    1130                 1135                 1140             


Pro Tyr  Asn Gln Gln Glu Ser  Tyr Ser Ala Tyr Phe  Asn His Val 
    1145                 1150                 1155             


Ile Thr  Gln Ile Ile Glu Glu  Leu Asn Thr 
    1160                 1165             


<210>  1439
<211>  1047
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1439

Met Glu Glu Gln Phe Leu Gln Lys Glu Arg Asn Met Gly Asp Asn Pro 
1               5                   10                  15      


Tyr Tyr Phe Cys His Phe Ile Asn Met Ala His His Asn Val Asn Leu 
            20                  25                  30          


Ile Leu Glu Glu Ile Tyr Asn Ser Val Tyr Glu Lys Tyr Thr Gln Asp 
        35                  40                  45              


Lys Glu Glu Asn Ile Lys Ala Ile Cys Asn Ser Met Ile Ser Lys Ser 
    50                  55                  60                  


Arg Lys Asn Pro Asp Glu Lys Ala Lys Met Met Asn Met Cys Ile Arg 
65                  70                  75                  80  


His Phe Pro Phe Leu Asp Tyr Tyr Lys Glu Lys Asp Gln Asn Ser Asp 
                85                  90                  95      


Val Leu Thr Ile Leu Leu Asn Gln Phe Leu Val Pro Leu His Gly Leu 
            100                 105                 110         


Arg Asn Gln Phe Ser His Tyr Lys His Pro Gln Glu Ala Tyr Cys Ile 
        115                 120                 125             


Ser Gly Phe Asp Leu Leu Phe Glu Gln Ala Lys Thr Gly Ala Gln Met 
    130                 135                 140                 


Arg Met Lys Tyr Ser Asp Glu Asp Ile Ser Lys Val Lys Ser Lys Val 
145                 150                 155                 160 


Val Asn His Asp Ser Ile Leu Thr Glu Arg Gly Ile Leu Phe Phe Ile 
                165                 170                 175     


Cys Leu Phe Leu Asp Lys Arg Asn Ile Tyr Leu Phe Leu Ser Lys Ile 
            180                 185                 190         


Lys Gly Phe Arg Asp Arg Arg Pro Asp Glu Lys Tyr Lys Ser Ala Thr 
        195                 200                 205             


Leu Glu Val Phe Ser Gln Tyr Tyr Cys His Val Pro Tyr Arg Lys Leu 
    210                 215                 220                 


Asp Ser Ser Asp Val Ala Leu Asp Met Leu Asn Glu Leu Asn Arg Cys 
225                 230                 235                 240 


Pro Lys Ala Leu Tyr Asp Val Leu Ser Asp Glu Asp Arg Glu Arg Phe 
                245                 250                 255     


Ile Val Asp Asn Val Glu Asn Ala Asp Asn Arg Asp Glu Ile Ser Asp 
            260                 265                 270         


Glu Asp Asp Glu Glu Met Pro Arg Ser Val Met Lys Arg Ser Asp Asp 
        275                 280                 285             


Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Glu Lys Gln Asn Asn Leu 
    290                 295                 300                 


Asp Glu Ile Ser Phe His Leu Tyr Leu Gly Arg Lys Glu Ala Lys Pro 
305                 310                 315                 320 


Ala His Glu Lys Val Ile Asn Gly Glu Met Arg Thr His Lys Ile Leu 
                325                 330                 335     


Lys Asp Ile His Val Phe Gly Arg Leu Glu Asn Tyr Arg Asn Glu Glu 
            340                 345                 350         


Ile Cys Asn Ala Ile Lys Asn Arg Glu Asp Ile Glu Phe Tyr Ala Pro 
        355                 360                 365             


Ser Tyr Arg Ile Val Glu Asn Arg Ile Gly Leu Leu Leu Arg Arg Gln 
    370                 375                 380                 


Asn Asp Phe Thr Leu Glu Glu Ala Asn Glu Glu Lys Ile Phe Glu Gly 
385                 390                 395                 400 


Asn Leu Cys Pro Asp Val Ile Leu Ser Thr His Glu Leu Gly Ala Leu 
                405                 410                 415     


Phe Phe Tyr Asn Tyr Leu His Lys Lys Gly Trp Ile Glu Ser Ala Pro 
            420                 425                 430         


Tyr Leu Tyr Ile Arg Asn Phe Ile Ser Asp Phe Lys Arg Phe Ile Glu 
        435                 440                 445             


Asp Ile Lys Asn Gly Lys Leu Thr Pro Val Glu Ser Glu Asp Asp Phe 
    450                 455                 460                 


Tyr Leu Ile Lys Lys Lys Lys Arg Asp Glu Thr Lys Asp Asn Asp Lys 
465                 470                 475                 480 


Lys Ser Ile Ala Val Gln Glu Arg Arg Arg Glu Lys Leu Lys Glu Lys 
                485                 490                 495     


Leu Lys Gly Tyr His Leu Glu Pro Asp Trp Ile Pro Asp Ala Cys Arg 
            500                 505                 510         


Glu Tyr Met Leu Gly Tyr Lys Ala Asp Gln Lys Asp Tyr Tyr Thr Lys 
        515                 520                 525             


Gln Arg Phe Cys Ser Met Lys Lys Glu Thr Asp Ser Arg Ile Lys Gln 
    530                 535                 540                 


Ile Glu Ala Ile Arg Lys Arg Glu Asp Asn Ser Ile Ile Arg Gln Thr 
545                 550                 555                 560 


Arg Val Gly Glu Ile Ala Gln Glu Leu Ala Arg Asp Ile Val Phe Leu 
                565                 570                 575     


Ile Pro Pro Tyr Lys Asn Glu Lys Gly Ala Asp Thr Lys Ile Asn Asn 
            580                 585                 590         


Met Glu Phe Asp Val Leu Gln Lys Met Leu Ala Tyr Phe Pro Leu Asn 
        595                 600                 605             


Lys Lys Asp Ile Tyr Pro Phe Leu Lys Asn Ile Arg Asn Trp Asp Lys 
    610                 615                 620                 


His Pro Phe Leu Lys Tyr Thr Leu His Thr Glu His Gln Ser Leu Leu 
625                 630                 635                 640 


Asp Phe Tyr Gln Asp Tyr Leu Asn Cys Lys Lys Arg Trp Ile Ser Lys 
                645                 650                 655     


Asn Ile Arg Tyr Asp Lys Gln Lys Gly Asn Tyr Leu Val Asp Ala Asn 
            660                 665                 670         


Lys Thr Glu Gln Glu Cys Arg Tyr Phe Leu Lys Thr Asp Lys Leu Arg 
        675                 680                 685             


Thr Ala Lys Glu Lys Glu Tyr Phe Glu Glu Pro Asp Lys Pro Val Tyr 
    690                 695                 700                 


Leu Pro Thr Gly Phe Phe Val Asp Pro Ile Val Glu Ala Met Arg Lys 
705                 710                 715                 720 


Asn Gly Tyr Glu Leu Lys Glu Asn Ser Asn Ile Val Gly Cys Leu Lys 
                725                 730                 735     


Ile Tyr Phe Val Ser Lys Ile Gln Pro Met Tyr Asp Leu Ser Arg Tyr 
            740                 745                 750         


Tyr Thr Tyr Tyr Asp Gly Lys Glu Glu Arg Ser Met Gln Leu Asp Asp 
        755                 760                 765             


Leu Lys Val Phe Ile Lys Glu Lys Phe Gly Asn Lys Arg Thr Asp Asp 
    770                 775                 780                 


Asn Thr Ile Arg Phe Leu Lys Lys Ala Ala Lys Arg Ile Arg Glu Asn 
785                 790                 795                 800 


Glu Ser Glu Ile Leu Val Arg Gln Met Asp Asp Cys Ala Leu Phe Leu 
                805                 810                 815     


Met Val Asn Asp Leu Leu Glu Gly Gly Lys Phe Asn Asp Glu Asp Ile 
            820                 825                 830         


Glu Asn Ile Gly Tyr Asn Lys His His Asn Leu Leu Asp His Glu Tyr 
        835                 840                 845             


Asp Met Cys Glu Thr Ile Tyr Gly Arg Lys Val Thr Ala Arg Leu Pro 
    850                 855                 860                 


Ile Lys Arg Tyr Gly Glu Phe Arg Arg Phe Met Lys Asp Arg Arg Leu 
865                 870                 875                 880 


Gln Asn Leu Val Lys Tyr Tyr Pro Gly Asp His Glu Thr Pro Ile Pro 
                885                 890                 895     


Ser Gly Ile Pro Glu Ser Gly Lys Ala Met Glu Lys Asn Lys Lys Tyr 
            900                 905                 910         


Thr Tyr Ser Asn Leu Cys Asp Glu Leu Glu Ile Tyr Asp Lys Glu Arg 
        915                 920                 925             


Asp Asn Val Leu Asn Leu Ile Tyr Glu Val Asp Lys Ile Leu Val Asp 
    930                 935                 940                 


His Phe Pro Asp Lys Ile Met Lys Glu Glu Asp Gly Tyr Tyr Glu His 
945                 950                 955                 960 


Tyr His Cys Leu Asp Phe Ala Lys Lys Glu Phe Gly Leu Glu Ser Asp 
                965                 970                 975     


Val Glu Leu Leu Ser Gln Asp Asn Phe Lys Asp Leu Arg Asn Ala Leu 
            980                 985                 990         


Tyr His Asn Gln Ile Pro Tyr Asn  Asp Trp Val Ala Asp  Lys Ile Ser 
        995                 1000                 1005             


Lys Asp  Thr Glu Glu Pro Met  Tyr Val Arg Arg Ile  Phe Ser Phe 
    1010                 1015                 1020             


Ile Arg  Thr Val Tyr Ser Arg  Leu Leu Asp Gln Ile  Lys Ile Lys 
    1025                 1030                 1035             


Ile Glu  Lys Asp Glu Tyr Lys  Cys Lys 
    1040                 1045         


<210>  1440
<211>  1175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1440

Met Thr Glu Gln Asn Glu Lys Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Thr His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn His Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Cys Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Glu Lys Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Thr Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Glu Asp Thr Asp Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Asp Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Phe Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Asn Tyr Ser Asp Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Gly Glu Ile Asp Thr Leu Asp 
    530                 535                 540                 


Arg Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Thr Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Gly Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Tyr Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Val Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Asp Leu Glu Ala Trp Ser His Ser Ala Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Ala Gly Ile Glu Asn Ala Ser Arg Glu Asn 
    850                 855                 860                 


Lys Lys Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Lys Ala 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Arg Gly Asp Lys Ile Asn Leu Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Ala Lys Glu His Pro Tyr Leu Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asp Ile Trp Thr 
945                 950                 955                 960 


Asp Val His Glu Gln Gly Ser Leu Asn Val Leu Asn Arg Val Lys Pro 
                965                 970                 975     


Met Arg Leu Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val 
            980                 985                 990         


His Lys Glu Gln Ala Pro Leu Ala  Thr Val Tyr Ile Glu  Glu Arg Asp 
        995                 1000                 1005             


Thr Lys  Leu Leu Lys Gln Gly  Asn Phe Lys Ser Phe  Val Lys Asp 
    1010                 1015                 1020             


Arg Arg  Leu Asn Gly Leu Phe  Ser Phe Val Asp Thr  Gly Ala Leu 
    1025                 1030                 1035             


Ala Met  Glu Gln Tyr Pro Ile  Ser Lys Leu Arg Val  Glu Tyr Glu 
    1040                 1045                 1050             


Leu Ala  Lys Tyr Gln Thr Ala  Arg Val Cys Ala Phe  Glu Gln Thr 
    1055                 1060                 1065             


Leu Glu  Leu Glu Glu Ser Leu  Leu Thr Arg Cys Pro  His Leu Pro 
    1070                 1075                 1080             


Asp Lys  Asn Phe Arg Lys Met  Leu Glu Ser Trp Ser  Asp Pro Leu 
    1085                 1090                 1095             


Leu Asp  Lys Trp Pro Asp Leu  His Arg Lys Val Arg  Leu Leu Ile 
    1100                 1105                 1110             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1115                 1120                 1125             


Glu Thr  Ile Phe Ser Ser Ile  Arg Lys Tyr Asp Pro  Ser Ser Pro 
    1130                 1135                 1140             


Asp Ala  Ile Glu Glu Arg Met  Gly Leu Asn Ile Ala  His Arg Leu 
    1145                 1150                 1155             


Ser Glu  Glu Val Lys Gln Ala  Lys Glu Met Val Glu  Arg Ile Ile 
    1160                 1165                 1170             


Gln Ala  
    1175 


<210>  1441
<211>  981
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1441

Met Ala Asp Lys Thr Ala Glu Leu Cys Leu Phe Tyr Asn Leu Ala Leu 
1               5                   10                  15      


Asn Arg Val Asn Asp Leu Val Arg Lys Tyr Glu Lys Asp Asp Thr Leu 
            20                  25                  30          


His Ile Glu Asp Val Asn Trp Glu Thr Phe Gly Gly Phe Arg Asn Val 
        35                  40                  45              


Ser Thr Tyr Leu His Leu Gln Val Phe Met Trp Lys Glu Pro Leu Ser 
    50                  55                  60                  


Ala Ser Phe Thr Thr Leu Ser Thr Ala Asp Lys Lys Arg Ile His Glu 
65                  70                  75                  80  


Leu Leu Arg Lys Leu Val Asp Leu Arg Asn Tyr Gln Ser His Tyr Tyr 
                85                  90                  95      


His Asp Ala Ser Val Leu Lys Phe Pro Gln Glu Leu Ile Asp Phe Ile 
            100                 105                 110         


Tyr Ser Arg Tyr Ala Asn Ala Arg Asn Ala Leu Glu Leu Lys Tyr Pro 
        115                 120                 125             


Glu Phe Val Thr Trp Phe His Asp Leu Asn Glu Asp Lys Val Ile Phe 
    130                 135                 140                 


Lys Asn Ser Lys Gly Glu Glu Arg Glu Asp Val Tyr Arg His Phe Tyr 
145                 150                 155                 160 


Phe Phe Asn Ala Asn Gly Asn Ile Glu Pro Glu Gly Lys Asn Phe Phe 
                165                 170                 175     


Leu Ser Phe Phe Leu Leu Lys Gly Glu Met Ser Lys Phe Leu Lys Lys 
            180                 185                 190         


Arg Ser Arg Cys Lys Arg Asp Asn Gly Glu Lys Tyr Gln Val Lys Thr 
        195                 200                 205             


Arg Leu Tyr Thr Tyr Tyr Cys His Arg Asp Gly Ser Asn Arg Phe Phe 
    210                 215                 220                 


Leu Glu Gly Lys Glu Glu Tyr Met Asp Thr Glu Glu Arg Leu Arg Arg 
225                 230                 235                 240 


Gln Gly Asn Thr Leu Leu Asn Tyr Leu Lys Ser Arg Pro Leu Val Asp 
                245                 250                 255     


Leu Lys Tyr Leu Pro Pro Ala Pro Pro Pro Gln Leu Leu Ser Lys Lys 
            260                 265                 270         


Glu Val Glu Glu Arg Lys Asn Arg Ala Glu Ser Gln Ala Glu Glu Glu 
        275                 280                 285             


Lys Thr Tyr Ile Arg Arg Thr Asp Lys Phe Ala Ser Leu Val Val Arg 
    290                 295                 300                 


Tyr Phe Met Asp Arg Ala Phe Leu Gly Tyr Glu Gln Glu Pro Cys Phe 
305                 310                 315                 320 


Tyr Trp His Val Lys Ser Leu Asp Leu Glu Glu Val Gln Lys Gln Lys 
                325                 330                 335     


Gln Glu Asn Arg Val Tyr Asp Ala Glu Gly Ala Tyr Tyr Tyr Gln Lys 
            340                 345                 350         


Glu Ser Arg Trp Ser Pro His Phe Val Pro Gly Glu Phe Pro Val Phe 
        355                 360                 365             


Val Asn Gly His Ile Lys Phe Arg Leu Gly Pro Glu Gly Met Glu Tyr 
    370                 375                 380                 


Ala Ile Ser Thr Gly Glu Leu Lys Asn Met Leu Tyr Leu Leu Leu Asn 
385                 390                 395                 400 


Ser Pro Arg Lys Asn Met Thr Glu Ile Gln Asp Ala Leu Leu Arg Tyr 
                405                 410                 415     


Gly Thr Gln Phe Ser Asn Ala Met Arg Glu Leu Thr Thr Glu His Asn 
            420                 425                 430         


Ile Arg Tyr Glu Ala Tyr Pro Leu Val Phe Glu Lys Gly Arg Asp Ser 
        435                 440                 445             


Val Leu Leu Ser Lys Met His Arg Lys Val Leu Asp Lys Glu Lys Phe 
    450                 455                 460                 


Asp Ala Ala Ile Tyr Thr Ala Ala Leu Glu Lys Ala Leu Asp Ser Arg 
465                 470                 475                 480 


Leu Arg Trp Val Glu Tyr Asn Cys Lys Pro Glu Val Tyr Thr Leu Tyr 
                485                 490                 495     


Thr Arg Asn Arg Met Asn Arg Ile Leu Leu Ser Cys Phe Asn Trp Tyr 
            500                 505                 510         


Leu Pro Asp Asp Ala Lys Leu Lys Pro Thr Glu Val Asn Lys Leu Ser 
        515                 520                 525             


Ile Tyr Asn Phe Val Ser Asp Asn Ser Tyr Thr Ser Asp Ala Thr Arg 
    530                 535                 540                 


Glu Ser Ile Val Val Gly Ile Gln Gln Lys Leu Asn Arg Ala Gln Phe 
545                 550                 555                 560 


Gly Ala Phe Ala Leu Leu Arg Thr Ala Ser Gly Leu Gln Asp Ala Tyr 
                565                 570                 575     


Leu Lys Met Leu Gly Lys Leu Arg Asp Ser Leu Leu Val Glu Lys Gln 
            580                 585                 590         


Gln Leu Leu Ala Gly Thr His Gly His Val Leu Lys Leu Gly Ala Arg 
        595                 600                 605             


Leu Gly Leu Ala Leu Pro Gly Thr Asp Val Ser Arg Asn Gly Thr Asp 
    610                 615                 620                 


Arg Met Gln Glu Leu Lys Gln Thr Ile Arg Ser Lys Pro Ile Leu Val 
625                 630                 635                 640 


Arg Asn Gly Phe Phe Lys Gln Tyr Phe Met Pro Glu Glu Pro Ala Ala 
                645                 650                 655     


Ala Arg Arg Asn Ser Ile Ser Ala Arg Leu Trp Lys Asn Arg Leu Leu 
            660                 665                 670         


Thr Gln Asn Leu Val Gln Gly Gln Tyr Lys Leu Gln Asn Gln Ser Glu 
        675                 680                 685             


Phe Ile Asn His Pro Glu Tyr Gly Leu Ala Asp Ile Ala Pro Asp Ile 
    690                 695                 700                 


Leu Ala Leu Val Gly Asp His Phe Asp Ala Cys Met Met Glu His Thr 
705                 710                 715                 720 


Gln Gly Ser Arg Gln Thr Phe Ala Gln Leu Val Asp Arg Phe Glu Ala 
                725                 730                 735     


Leu Tyr Thr Gly Ser Lys Ser Pro Glu Lys Arg Lys Gln Ile Ala Asp 
            740                 745                 750         


Ala Ile Asn Tyr Ser Arg Val Leu Lys Glu Ile Gln Ala Gln Asp Ala 
        755                 760                 765             


Leu Leu Leu Gln Val Phe Phe Glu Tyr His Asn Arg Lys Leu Pro Leu 
    770                 775                 780                 


Asn Arg Arg Glu Leu Lys Tyr Lys Pro Leu Ser Thr Leu Phe Glu Glu 
785                 790                 795                 800 


Glu Tyr Glu Leu Gln Ile Asp Ala Ser Tyr Lys Val Gln Leu Lys Tyr 
                805                 810                 815     


Lys Gln Leu Asp Asp Leu Ser Thr His Trp Asn Arg Thr Lys Ile Glu 
            820                 825                 830         


Gln Leu Phe Lys Asn Glu Ala Tyr Trp Asn Leu Ala Ile Ile Ala Glu 
        835                 840                 845             


Leu Asp Ala Lys Gly Lys Lys Ser Met Gln Glu Lys Ile Arg Ile Val 
    850                 855                 860                 


Met Asp Arg Val Trp Asn Asp Ser Tyr His Tyr Ile Lys Ala Phe Leu 
865                 870                 875                 880 


His Ile Glu Lys Glu Ala Val Glu Ile Gln Lys Lys Glu Gly Ile Pro 
                885                 890                 895     


Ala Thr Glu Leu Ile Ser Arg Ser Gln Ala Ile Arg Ser Pro Gly Leu 
            900                 905                 910         


Pro Arg Ile Glu Gly Lys Val Leu Leu Ser Thr Phe Ala Gly Leu Asp 
        915                 920                 925             


Glu Gly Lys Ile Asn Arg Phe Ile Gln Leu Arg Asn Ala Ala Phe His 
    930                 935                 940                 


Ala Gly Ile Pro Glu Glu Cys Val Lys Tyr Glu Lys Val Lys Asp Asp 
945                 950                 955                 960 


Leu Tyr Ala Ala Thr Gly Val Lys Lys Pro Val Val Lys Pro Lys Lys 
                965                 970                 975     


Tyr Glu Lys Lys Lys 
            980     


<210>  1442
<211>  1169
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1442

Met Asp Thr Asn Ala Pro Lys Arg Tyr Thr Met Glu Thr Glu Pro Trp 
1               5                   10                  15      


Tyr Tyr Gly Gly Tyr Leu Asn Met Ala Arg His Asn Met Phe Leu Ile 
            20                  25                  30          


Ser Asn Glu Ile Val Thr Lys Leu Lys Leu Gly Phe Ala Lys Lys Lys 
        35                  40                  45              


Ala Asp Thr Ala Glu Ala Glu Pro Leu Ser Pro Lys Leu Leu Lys Asp 
    50                  55                  60                  


Asp Gly Ala Leu Pro Ser Ser Phe Leu Thr Asp Lys Asp Tyr Leu Glu 
65                  70                  75                  80  


Lys Asn Asn Pro Arg Arg Ile Tyr Ala Leu Leu Arg Arg Phe Leu Pro 
                85                  90                  95      


Leu Ala Ala Leu Phe Ala Thr Asp Thr Thr Ser Asp Glu Tyr Ser Glu 
            100                 105                 110         


Lys Glu Leu Asp Ile Ala Gln Met Ser Asp Ile Leu Lys Glu Leu Phe 
        115                 120                 125             


Ala Glu Leu Asn Arg Phe Arg Asn Asp Tyr Ser His Tyr Tyr Ser Val 
    130                 135                 140                 


Asp Arg Glu Asp Arg Arg Lys Thr Glu Leu Asp Glu Gln Val Ala Val 
145                 150                 155                 160 


Phe Leu Arg Asn Thr Phe Tyr Tyr Ala Ile His Leu Ala Arg Lys Arg 
                165                 170                 175     


Phe Glu Gly Val Ile Asp Ala Arg His Phe Gln Phe Val Glu Lys Glu 
            180                 185                 190         


Ile Ala Pro Gly Ile Val Arg Ala Asp Gly Lys Val Thr Thr Arg Gly 
        195                 200                 205             


Leu Val Phe Phe Cys Cys Leu Phe Leu Asp Lys Glu Asn Ala Phe His 
    210                 215                 220                 


Phe Ile Asn Lys Val Ser Gly Phe Lys Asn Thr Ser Thr Phe Asp Phe 
225                 230                 235                 240 


Leu Ala Thr Arg Glu Val Phe Ser Val Leu Cys Ala Lys Met Pro His 
                245                 250                 255     


Asp Arg Phe Ile Ser Glu Asn Pro Glu Gln Ala Leu Gln Leu Asp Ile 
            260                 265                 270         


Leu Asn Tyr Leu Asn Arg Ala Pro Ala Glu Leu Tyr Gln Ala Leu Ser 
        275                 280                 285             


Ala Glu Ala Lys Lys Pro Phe Gln Pro Gln Leu Gly Lys Asp Glu Arg 
    290                 295                 300                 


Tyr Asn Met Thr Gln Asn Ser Ile Pro Glu His Ile Glu Glu Glu Ser 
305                 310                 315                 320 


Tyr Glu Asn Tyr Leu Glu Ser Ile Ser Val Lys Arg Arg His Thr Asp 
                325                 330                 335     


Arg Phe Pro Glu Phe Ala Leu Lys Phe Leu Asp Arg Ser Asp Thr Phe 
            340                 345                 350         


Asp Phe Tyr Phe Gln Leu His Leu Gly Lys Ser Ile Phe Arg Ala Tyr 
        355                 360                 365             


Pro Lys Thr Leu Leu Gly Glu Thr Pro Glu Glu Pro Asn Arg Ser Ile 
    370                 375                 380                 


Ser Gly Asp Ile Lys Thr Phe Arg Asn Leu His Thr Phe Leu Gly Asn 
385                 390                 395                 400 


His Glu Glu Glu Arg Glu Gln Val Lys Ala Gln Ile Thr Ala Glu Ala 
                405                 410                 415     


Asp Phe Leu Lys Glu Phe Ser Gly Glu Tyr Ala Glu Tyr Phe Thr Gln 
            420                 425                 430         


Tyr Ala Pro His Phe His Ile Val Asn Asn Lys Ile Gly Ile Leu Pro 
        435                 440                 445             


Tyr Ser Asn Lys Lys Tyr His Glu Lys Leu Tyr Arg Pro Leu Ala Pro 
    450                 455                 460                 


Leu Ala Phe Leu Ser Val His Glu Leu Pro Lys Val Ala Leu Leu Glu 
465                 470                 475                 480 


Ile Leu Glu Pro Gly Ser Ala Ala Arg Cys Ile His Glu Cys Ile Gln 
                485                 490                 495     


Lys Ser Thr Ile Gln Val Leu Asn Asn Asp Phe Ile Glu Glu Val Lys 
            500                 505                 510         


Gln Ser Leu Ala Phe Asp Lys Glu Ile Lys Arg Gln Phe Trp Asp Asp 
        515                 520                 525             


Lys Leu Pro His Ile Glu Pro Ala Ala Ala Asp Lys Lys Ala Phe Asp 
    530                 535                 540                 


Asp Ile Arg Asn Lys Leu Asp Gln Glu Lys Lys Gly Arg Asn Arg Gln 
545                 550                 555                 560 


Ser Ala Thr Gln Asn Leu Asn Asn Arg Arg Lys Ala Leu Phe Tyr Ala 
                565                 570                 575     


Gln Tyr Val Ala Arg Val Asn Glu Arg Lys Glu Lys Leu Asn Thr Ile 
            580                 585                 590         


Leu Ala Glu Tyr Gly Leu Asn His Arg Gln Ile Pro Gly Arg Ile Leu 
        595                 600                 605             


Asp Tyr Trp Leu Arg Ile Val Glu Val Glu Thr Ala Ala Ala Ile Lys 
    610                 615                 620                 


Asn Arg Ile Arg Ala Glu Arg Lys Glu Cys Lys Gln Arg Ile Lys Ala 
625                 630                 635                 640 


Leu Asp Ala Gly Lys Gly Pro Lys Ile Gly Glu Met Ala Ser Tyr Leu 
                645                 650                 655     


Ala Arg Asp Ile Val Asn Leu Val Ile Asp Glu Lys Arg Lys Ala Lys 
            660                 665                 670         


Ile Ser Ser Phe Tyr Tyr Asp Gln Leu Gln Glu Cys Leu Ala Leu Tyr 
        675                 680                 685             


Ala Asp Ala Ala Lys Lys Gln Arg Phe Leu Asp Ile Cys Thr Lys Glu 
    690                 695                 700                 


Leu Gln Leu Phe Asp Thr Ala Asn Gly His Pro Phe Leu Ala Asp Leu 
705                 710                 715                 720 


Pro Phe Asn Lys Ile His Lys Thr Lys Asp Leu Tyr Arg Lys Tyr Ile 
                725                 730                 735     


Glu Arg Lys Gly Thr Ala Gln Arg Met Gly Lys Val Trp Asn Arg Lys 
            740                 745                 750         


Glu Lys Cys Phe Lys Ser Glu Lys Lys Glu Asp Ser Trp Leu Cys Asn 
        755                 760                 765             


Thr Phe Tyr Ser Lys Val Lys Ala Lys Asp Lys Thr Glu Ile Gln Ile 
    770                 775                 780                 


Pro Glu Ser Gly Lys Gly Val Pro Leu Ser Tyr Arg Arg Leu Ala Arg 
785                 790                 795                 800 


Glu Glu Ser Pro Leu Pro Ala Trp Leu His Ser Val Thr Lys Gly Asn 
                805                 810                 815     


Val Glu Lys Ala Asp Ser Lys Pro Ile Asp Leu Pro Leu Asn Leu Phe 
            820                 825                 830         


Asp Asp Cys Leu Asn Arg Leu Leu Thr Ala Glu Leu Gly Asp Arg Leu 
        835                 840                 845             


Gln Ala Gly Glu Lys Tyr Asn Tyr Ser Lys Leu Leu Ala Ile Trp Arg 
    850                 855                 860                 


Pro Glu Ile Gln Pro Phe Tyr Asn Trp Glu Arg Glu Tyr Val Leu Phe 
865                 870                 875                 880 


Lys Asp Glu Pro Tyr Glu Gly Arg Val Ala Phe Lys Pro Gly Ala Lys 
                885                 890                 895     


Ala Thr Phe Arg Glu Tyr Tyr Glu Pro Val Leu Asp Ser Val Tyr Arg 
            900                 905                 910         


Lys Arg Lys Arg Val Asp Pro Gln Ile Gln Glu Val Gln Val Arg Arg 
        915                 920                 925             


Val Phe Lys Lys Ala Ile Asp Glu Asn Glu Lys Gln Leu Arg Phe Tyr 
    930                 935                 940                 


Gln Ala Lys Asp Arg Ile Leu Met Leu Met Leu Asp Arg Met Ala Thr 
945                 950                 955                 960 


Glu Lys Leu Asn Ile Ser Leu Ala Glu Ile Tyr Pro Gly Ser Ala Thr 
                965                 970                 975     


Ser Pro Leu Asn Val Gln Thr Thr Ile Ser Glu Lys Ile Gly Asp Lys 
            980                 985                 990         


Tyr Asn Lys Tyr Ile Ser Tyr Thr  Arg Lys Arg Lys Asp  Tyr Ala Leu 
        995                 1000                 1005             


Phe Arg  Arg Phe Ile Thr Asp  Arg Arg Met His Gly  Leu Phe Ala 
    1010                 1015                 1020             


Trp Tyr  Thr Gln Asp Thr Ile  Ala Phe Glu Asp Leu  Lys Lys Glu 
    1025                 1030                 1035             


Leu Asp  Asp Tyr Glu Lys Leu  Arg Pro Gln Val Leu  Glu Met Cys 
    1040                 1045                 1050             


Phe Thr  Leu Glu Gln Ala Ile  Ile Ser His Met Ser  Lys Asp Glu 
    1055                 1060                 1065             


Leu Asp  Ala Met Ala Glu Lys  Ala Asn Ala Lys Ala  Ala Glu Lys 
    1070                 1075                 1080             


Asn Arg  Arg Asn Thr His Val  Glu His Gly Leu Tyr  Met Asp Trp 
    1085                 1090                 1095             


Leu Arg  Lys Tyr Ala Ile Ile  Thr Phe Glu Glu Glu  Thr Phe Tyr 
    1100                 1105                 1110             


Arg Glu  Ile Arg Asn Lys Phe  Ser His Asn Glu Phe  Pro Arg Ala 
    1115                 1120                 1125             


Asp Arg  Leu Pro Lys Ala Val  Arg Glu Ser Ser Asp  Gly Ile Thr 
    1130                 1135                 1140             


Ile Thr  His Ser Ile Val Thr  Tyr Tyr Leu Gln Glu  Leu Gln Lys 
    1145                 1150                 1155             


Leu Met  Glu Glu Lys Gly Val  Phe Thr Ala Leu 
    1160                 1165                 


<210>  1443
<211>  1135
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1443

Met Asn Thr Val Pro Ala Ser Glu Asn Lys Gly Gln Ser Arg Thr Val 
1               5                   10                  15      


Glu Asp Asp Pro Gln Tyr Phe Gly Leu Tyr Leu Asn Leu Ala Arg Glu 
            20                  25                  30          


Asn Leu Ile Glu Val Glu Ser His Val Arg Ile Lys Phe Gly Lys Lys 
        35                  40                  45              


Lys Leu Asn Glu Glu Ser Leu Lys Gln Ser Leu Leu Cys Asp His Leu 
    50                  55                  60                  


Leu Ser Val Asp Arg Trp Thr Lys Val Tyr Gly His Ser Arg Arg Tyr 
65                  70                  75                  80  


Leu Pro Phe Leu His Tyr Phe Asp Pro Asp Ser Gln Ile Glu Lys Asp 
                85                  90                  95      


His Asp Ser Lys Thr Gly Val Asp Pro Asp Ser Ala Gln Arg Leu Ile 
            100                 105                 110         


Arg Glu Leu Tyr Ser Leu Leu Asp Phe Leu Arg Asn Asp Phe Ser His 
        115                 120                 125             


Asn Arg Leu Asp Gly Thr Thr Phe Glu His Leu Glu Val Ser Pro Asp 
    130                 135                 140                 


Ile Ser Ser Phe Ile Thr Gly Thr Tyr Ser Leu Ala Cys Gly Arg Ala 
145                 150                 155                 160 


Gln Ser Arg Phe Ala Val Phe Phe Lys Pro Asp Asp Phe Val Leu Ala 
                165                 170                 175     


Lys Asn Arg Lys Glu Gln Leu Ile Ser Val Ala Asp Gly Lys Glu Cys 
            180                 185                 190         


Leu Thr Val Ser Gly Phe Ala Phe Phe Ile Cys Leu Phe Leu Asp Arg 
        195                 200                 205             


Glu Gln Ala Ser Gly Met Leu Ser Arg Ile Arg Gly Phe Lys Arg Thr 
    210                 215                 220                 


Asp Glu Asn Trp Ala Arg Ala Val His Glu Thr Phe Cys Asp Leu Cys 
225                 230                 235                 240 


Ile Arg His Pro His Asp Arg Leu Glu Ser Ser Asn Thr Lys Glu Ala 
                245                 250                 255     


Leu Leu Leu Asp Met Leu Asn Glu Leu Asn Arg Cys Pro Arg Ile Leu 
            260                 265                 270         


Tyr Asp Met Leu Pro Glu Glu Glu Arg Ala Gln Phe Leu Pro Ala Leu 
        275                 280                 285             


Asp Glu Asn Ser Met Asn Asn Leu Ser Glu Asn Ser Leu Asp Glu Glu 
    290                 295                 300                 


Ser Arg Leu Leu Trp Asp Gly Ser Ser Asp Trp Ala Glu Ala Leu Thr 
305                 310                 315                 320 


Lys Arg Ile Arg His Gln Asp Arg Phe Pro Tyr Leu Met Leu Arg Phe 
                325                 330                 335     


Ile Glu Glu Met Asp Leu Leu Lys Gly Ile Arg Phe Arg Val Asp Leu 
            340                 345                 350         


Gly Glu Ile Glu Leu Asp Ser Tyr Ser Lys Lys Val Gly Arg Asn Gly 
        355                 360                 365             


Glu Tyr Asp Arg Thr Ile Thr Asp His Ala Leu Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Asp Phe Gln Asn Glu Glu Glu Val Ser Arg Met Ile Ser Gly Glu 
385                 390                 395                 400 


Ala Ser Tyr Pro Val Arg Phe Ser Leu Phe Ala Pro Arg Tyr Ala Ile 
                405                 410                 415     


Tyr Asp Asn Lys Ile Gly Tyr Cys His Thr Ser Asp Pro Val Tyr Pro 
            420                 425                 430         


Lys Ser Lys Thr Gly Glu Lys Arg Ala Leu Ser Asn Pro Gln Ser Met 
        435                 440                 445             


Gly Phe Ile Ser Val His Asp Leu Arg Lys Leu Leu Leu Met Glu Leu 
    450                 455                 460                 


Leu Cys Glu Gly Ser Phe Ser Arg Met Gln Ser Asp Phe Leu Arg Lys 
465                 470                 475                 480 


Ala Asn Arg Ile Leu Asp Glu Thr Ala Glu Gly Lys Leu Gln Phe Ser 
                485                 490                 495     


Ala Leu Phe Pro Glu Met Arg His Arg Phe Ile Pro Pro Gln Asn Pro 
            500                 505                 510         


Lys Ser Lys Asp Arg Arg Glu Lys Ala Glu Thr Thr Leu Glu Lys Tyr 
        515                 520                 525             


Lys Gln Glu Ile Lys Gly Arg Lys Asp Lys Leu Asn Ser Gln Leu Leu 
    530                 535                 540                 


Ser Ala Phe Asp Met Asp Gln Arg Gln Leu Pro Ser Arg Leu Leu Asp 
545                 550                 555                 560 


Glu Trp Met Asn Ile Arg Pro Ala Ser His Ser Val Lys Leu Arg Thr 
                565                 570                 575     


Tyr Val Lys Gln Leu Asn Glu Asp Cys Arg Leu Arg Leu Arg Lys Phe 
            580                 585                 590         


Arg Lys Asp Gly Asp Gly Lys Ala Arg Ala Ile Pro Leu Val Gly Glu 
        595                 600                 605             


Met Ala Thr Phe Leu Ser Gln Asp Ile Val Arg Met Ile Ile Ser Glu 
    610                 615                 620                 


Glu Thr Lys Lys Leu Ile Thr Ser Ala Tyr Tyr Asn Glu Met Gln Arg 
625                 630                 635                 640 


Ser Leu Ala Gln Tyr Ala Gly Glu Glu Asn Arg Arg Gln Phe Arg Ala 
                645                 650                 655     


Ile Val Ala Glu Leu Arg Leu Leu Asp Pro Ser Ser Gly His Pro Phe 
            660                 665                 670         


Leu Ser Ala Thr Met Glu Thr Ala His Arg Tyr Thr Glu Gly Phe Tyr 
        675                 680                 685             


Lys Cys Tyr Leu Glu Lys Lys Arg Glu Trp Leu Ala Lys Thr Phe Tyr 
    690                 695                 700                 


Arg Pro Glu Gln Asp Glu Asn Thr Lys Arg Arg Ile Ser Val Phe Phe 
705                 710                 715                 720 


Val Pro Asp Gly Glu Ala Arg Lys Leu Leu Pro Leu Leu Ile Arg Arg 
                725                 730                 735     


Arg Met Lys Glu Gln Asn Asp Leu Gln Asp Trp Ile Arg Asn Lys Gln 
            740                 745                 750         


Ala His Pro Ile Asp Leu Pro Ser His Leu Phe Asp Ser Lys Val Met 
        755                 760                 765             


Glu Leu Leu Lys Val Lys Asp Gly Lys Lys Lys Trp Asn Glu Ala Phe 
    770                 775                 780                 


Lys Asp Trp Trp Ser Thr Lys Tyr Pro Asp Gly Met Gln Pro Phe Tyr 
785                 790                 795                 800 


Gly Leu Arg Arg Glu Leu Asn Ile His Gly Lys Ser Val Ser Tyr Ile 
                805                 810                 815     


Pro Ser Asp Gly Lys Lys Phe Ala Asp Cys Tyr Thr His Leu Met Glu 
            820                 825                 830         


Lys Thr Val Arg Asp Lys Lys Arg Glu Leu Arg Thr Ala Gly Lys Pro 
        835                 840                 845             


Val Pro Pro Asp Leu Ala Ala Asp Ile Lys Arg Ser Phe His Arg Ala 
    850                 855                 860                 


Val Asn Glu Arg Glu Phe Met Leu Arg Leu Val Gln Glu Asp Asp Arg 
865                 870                 875                 880 


Leu Met Leu Met Ala Ile Asn Lys Met Met Thr Asp Arg Glu Glu Asp 
                885                 890                 895     


Ile Leu Pro Gly Leu Lys Asn Ile Asp Ser Ile Leu Asp Glu Glu Asn 
            900                 905                 910         


Gln Phe Ser Leu Ala Val His Ala Lys Val Leu Glu Lys Glu Gly Glu 
        915                 920                 925             


Gly Gly Asp Asn Ser Leu Ser Leu Val Pro Ala Thr Ile Glu Ile Lys 
    930                 935                 940                 


Ser Lys Arg Lys Asp Trp Ser Lys Tyr Ile Arg Tyr Arg Tyr Asp Arg 
945                 950                 955                 960 


Arg Val Pro Gly Leu Met Ser His Phe Pro Glu His Lys Ala Thr Leu 
                965                 970                 975     


Asp Glu Val Lys Thr Leu Leu Gly Glu Tyr Asp Arg Cys Arg Ile Lys 
            980                 985                 990         


Ile Phe Asp Trp Ala Phe Ala Leu  Glu Gly Ala Ile Met  Ser Asp Arg 
        995                 1000                 1005             


Asp Leu  Lys Pro Tyr Leu His  Glu Ser Ser Ser Arg  Glu Gly Lys 
    1010                 1015                 1020             


Ser Gly  Glu His Ser Thr Leu  Val Lys Met Leu Val  Glu Lys Lys 
    1025                 1030                 1035             


Gly Cys  Leu Thr Pro Asp Glu  Ser Gln Tyr Leu Ile  Leu Ile Arg 
    1040                 1045                 1050             


Asn Lys  Ala Ala His Asn Gln  Phe Pro Cys Ala Ala  Glu Met Pro 
    1055                 1060                 1065             


Leu Ile  Tyr Arg Asp Val Ser  Ala Lys Val Gly Ser  Ile Glu Gly 
    1070                 1075                 1080             


Ser Ser  Ala Lys Asp Leu Pro  Glu Gly Ser Ser Leu  Val Asp Ser 
    1085                 1090                 1095             


Leu Trp  Lys Lys Tyr Glu Met  Ile Ile Arg Lys Ile  Leu Pro Ile 
    1100                 1105                 1110             


Leu Asp  Pro Glu Asn Arg Phe  Phe Gly Lys Leu Leu  Asn Asn Met 
    1115                 1120                 1125             


Ser Gln  Pro Ile Asn Asp Leu  
    1130                 1135 


<210>  1444
<211>  1175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1444

Met Thr Glu Gln Asn Glu Lys Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Phe Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Thr His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Asn Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Lys Tyr Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Glu Lys Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Thr Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Pro Leu Ala Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Ser Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Phe Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Glu Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Gly Glu Ile Asn Thr Arg Asp 
    530                 535                 540                 


Glu Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Lys His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Gly Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Tyr Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Ser Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Asp Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Gln Asp Leu Glu Ala Trp Ser His Ser Ala Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Ala Gly Ile Glu Asn Ala Ser Arg Glu Asn 
    850                 855                 860                 


Lys Lys Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Glu Ala 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Lys Ala Asp Lys Ile Asn Ile Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Ala Lys Glu His Pro Tyr His Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asp Ile Arg Thr 
945                 950                 955                 960 


Glu Val Gln Glu Gln Gly Ser Leu Asn Val Leu Asn His Val Lys Pro 
                965                 970                 975     


Met Arg Leu Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val 
            980                 985                 990         


His Lys Glu Gln Ala Pro Leu Ala  Thr Val Tyr Ile Glu  Glu Arg Asp 
        995                 1000                 1005             


Thr Lys  Leu Leu Lys Gln Gly  Asn Phe Lys Ser Phe  Val Lys Asp 
    1010                 1015                 1020             


Arg Arg  Leu Asn Gly Leu Phe  Ser Phe Val Asp Thr  Gly Gly Leu 
    1025                 1030                 1035             


Ala Met  Glu Gln Tyr Pro Ile  Ser Lys Leu Arg Val  Glu Tyr Glu 
    1040                 1045                 1050             


Leu Ala  Lys Tyr Gln Thr Ala  Arg Val Cys Val Phe  Glu Gln Thr 
    1055                 1060                 1065             


Leu Glu  Leu Glu Glu Ser Leu  Leu Thr Arg Tyr Pro  His Leu Pro 
    1070                 1075                 1080             


Asp Lys  Asn Phe Arg Lys Met  Leu Glu Ser Trp Ser  Asp Pro Leu 
    1085                 1090                 1095             


Leu Ala  Lys Trp Pro Glu Leu  His Glu Lys Val Arg  Leu Leu Ile 
    1100                 1105                 1110             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1115                 1120                 1125             


Glu Ala  Val Phe Ser Pro Ile  Arg Lys Tyr Asp Pro  Ser Ser Pro 
    1130                 1135                 1140             


Asp Ala  Ile Glu Glu Arg Met  Gly Leu Asn Ile Ala  His Arg Leu 
    1145                 1150                 1155             


Ser Glu  Glu Val Lys Gln Ala  Lys Glu Met Val Glu  Arg Ile Ile 
    1160                 1165                 1170             


Gln Ala  
    1175 


<210>  1445
<211>  1175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1445

Met Thr Glu Gln Asn Glu Arg Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Phe Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Ala His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Asn Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Tyr Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Gly Thr Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Ser Glu Thr Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Phe Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Asp Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Gly Glu Ile Asp Thr Leu Asp 
    530                 535                 540                 


Arg Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Lys Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Ser Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Leu Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Asp Leu Glu Ala Trp Ala His Ser Ala Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Val Gly Ile Glu Tyr Ala Ser Arg Glu Asn 
    850                 855                 860                 


Lys Lys Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Glu Thr 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Lys Thr Asp Lys Ile Asn Ile Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Thr Lys Glu His Pro Tyr Leu Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asn Ile Arg Thr 
945                 950                 955                 960 


Asp Val Gln Glu Gln Gly Ser Leu Asn Val Leu Asn His Val Lys Pro 
                965                 970                 975     


Met Arg Leu Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val 
            980                 985                 990         


His Lys Glu Gln Ala Pro Leu Ala  Thr Val Tyr Ile Glu  Glu Arg Asp 
        995                 1000                 1005             


Thr Lys  Leu Leu Lys Gln Gly  Asn Phe Lys Ser Phe  Val Lys Asp 
    1010                 1015                 1020             


Arg Arg  Leu Asn Gly Leu Phe  Ser Phe Val Asp Thr  Gly Gly Leu 
    1025                 1030                 1035             


Ala Met  Glu Gln Tyr Pro Ile  Ser Lys Leu Arg Val  Glu Tyr Glu 
    1040                 1045                 1050             


Leu Ala  Lys Tyr Gln Thr Ala  Arg Val Cys Ala Phe  Glu Gln Thr 
    1055                 1060                 1065             


Leu Glu  Leu Glu Glu Ser Leu  Leu Thr Arg Tyr Pro  His Leu Pro 
    1070                 1075                 1080             


Asp Lys  Ser Phe Arg Glu Met  Leu Glu Ser Trp Ser  Asp Pro Leu 
    1085                 1090                 1095             


Leu Asp  Lys Trp Pro Asp Leu  Gln Arg Glu Val Arg  Leu Leu Ile 
    1100                 1105                 1110             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1115                 1120                 1125             


Glu Thr  Ile Phe Ser Ser Ile  Arg Lys Tyr Asp Pro  Ser Ser Pro 
    1130                 1135                 1140             


Asp Ala  Ile Glu Glu Arg Met  Gly Leu Asn Ile Ala  His Arg Leu 
    1145                 1150                 1155             


Ser Glu  Glu Val Lys Gln Ala  Lys Glu Met Ala Glu  Arg Ile Ile 
    1160                 1165                 1170             


Gln Ala  
    1175 


<210>  1446
<211>  1135
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1446

Met Asn Thr Val Pro Ala Ser Glu Asn Lys Gly Gln Ser Arg Thr Val 
1               5                   10                  15      


Glu Asp Asp Pro Gln Tyr Phe Gly Leu Tyr Leu Asn Leu Ala Arg Glu 
            20                  25                  30          


Asn Leu Ile Glu Val Glu Ser His Val Arg Ile Lys Phe Gly Lys Lys 
        35                  40                  45              


Lys Leu Asn Glu Glu Ser Leu Lys Gln Ser Leu Leu Cys Asp His Leu 
    50                  55                  60                  


Leu Ser Val Asp Arg Trp Thr Lys Val Tyr Gly His Ser Arg Arg Tyr 
65                  70                  75                  80  


Leu Pro Phe Leu His Tyr Phe Asp Pro Asp Ser Gln Ile Glu Lys Asp 
                85                  90                  95      


His Asp Ser Lys Thr Gly Val Asp Pro Asp Ser Ala Gln Arg Leu Ile 
            100                 105                 110         


Arg Glu Leu Tyr Ser Leu Leu Asp Phe Leu Arg Asn Asp Phe Ser His 
        115                 120                 125             


Asn Arg Leu Asp Gly Thr Thr Phe Glu His Leu Glu Val Ser Pro Asp 
    130                 135                 140                 


Ile Ser Ser Phe Ile Thr Gly Thr Tyr Ser Leu Ala Cys Gly Arg Ala 
145                 150                 155                 160 


Gln Ser Arg Phe Ala Asp Phe Phe Lys Leu Asp Asp Phe Val Leu Ala 
                165                 170                 175     


Lys Asn Arg Lys Glu Gln Leu Ile Ser Val Ala Asp Gly Lys Glu Cys 
            180                 185                 190         


Leu Thr Val Ser Gly Leu Ala Phe Phe Ile Cys Leu Phe Leu Asp Arg 
        195                 200                 205             


Glu Gln Ala Ser Gly Met Leu Ser Arg Ile Arg Gly Phe Lys Arg Thr 
    210                 215                 220                 


Asp Glu Asn Trp Ala Arg Ala Val His Glu Thr Phe Cys Asp Leu Cys 
225                 230                 235                 240 


Ile Arg His Pro His Asp Arg Leu Glu Ser Ser Asn Thr Lys Glu Ala 
                245                 250                 255     


Leu Leu Leu Asp Met Leu Asn Glu Leu Asn Arg Cys Pro Arg Ile Leu 
            260                 265                 270         


Tyr Asp Met Leu Pro Glu Glu Glu Arg Ala Gln Phe Leu Pro Ala Leu 
        275                 280                 285             


Asp Glu Asn Ser Met Asn Asn Leu Ser Glu Asn Ser Leu Asn Glu Glu 
    290                 295                 300                 


Ser Arg Leu Leu Trp Asp Gly Ser Ser Asp Trp Ala Glu Ala Leu Thr 
305                 310                 315                 320 


Lys Arg Ile Arg His Gln Asp Arg Phe Pro Tyr Leu Met Leu Arg Phe 
                325                 330                 335     


Ile Glu Glu Met Asp Leu Leu Lys Gly Ile Arg Phe Arg Val Asp Leu 
            340                 345                 350         


Gly Glu Ile Glu Leu Asp Ser Tyr Ser Lys Lys Val Gly Arg Asn Gly 
        355                 360                 365             


Glu Tyr Asp Arg Thr Ile Thr Asp His Ala Leu Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Asp Phe Gln Asn Glu Glu Glu Val Ser Arg Met Ile Ser Gly Glu 
385                 390                 395                 400 


Ala Ser Tyr Pro Val Arg Phe Ser Leu Phe Ala Pro Arg Tyr Ala Ile 
                405                 410                 415     


Tyr Asp Asn Lys Ile Gly Tyr Cys His Thr Ser Asp Pro Val Tyr Pro 
            420                 425                 430         


Lys Ser Lys Thr Gly Glu Lys Arg Ala Leu Ser Asn Pro Arg Ser Met 
        435                 440                 445             


Gly Phe Ile Ser Val His Asp Leu Arg Lys Leu Leu Leu Met Glu Leu 
    450                 455                 460                 


Leu Cys Glu Gly Ser Phe Ser Arg Met Gln Ser Asp Phe Leu Arg Lys 
465                 470                 475                 480 


Ala Asn Arg Ile Leu Asp Glu Thr Ala Glu Gly Lys Leu Gln Phe Ser 
                485                 490                 495     


Ala Leu Phe Pro Glu Met Arg His Arg Phe Ile Pro Pro Gln Asn Pro 
            500                 505                 510         


Lys Ser Lys Asp Arg Arg Glu Lys Ala Glu Thr Thr Leu Glu Lys Tyr 
        515                 520                 525             


Lys Gln Glu Ile Lys Gly Arg Lys Asp Lys Leu Asn Ser Gln Leu Leu 
    530                 535                 540                 


Ser Ala Phe Asp Met Asn Gln Arg Gln Leu Pro Ser Arg Leu Leu Asp 
545                 550                 555                 560 


Glu Trp Met Asn Ile Arg Pro Ala Ser His Ser Val Lys Leu Arg Thr 
                565                 570                 575     


Tyr Val Lys Gln Leu Asn Glu Asp Cys Arg Leu Arg Leu Arg Lys Phe 
            580                 585                 590         


Arg Lys Asp Gly Asp Gly Lys Ala Arg Ala Ile Pro Leu Val Gly Glu 
        595                 600                 605             


Met Ala Thr Phe Leu Ser Gln Asp Ile Val Arg Met Ile Ile Ser Glu 
    610                 615                 620                 


Glu Thr Lys Lys Leu Ile Thr Ser Ala Tyr Tyr Asn Glu Met Gln Arg 
625                 630                 635                 640 


Ser Leu Ala Gln Tyr Ala Gly Glu Glu Asn Arg Arg Gln Phe Arg Ala 
                645                 650                 655     


Ile Val Ala Glu Leu Arg Leu Leu Asp Pro Ser Ser Gly His Pro Phe 
            660                 665                 670         


Leu Ser Ala Thr Met Glu Thr Ala His Arg Tyr Thr Glu Asp Phe Tyr 
        675                 680                 685             


Lys Cys Tyr Phe Glu Lys Lys Arg Glu Trp Leu Ala Lys Thr Phe Tyr 
    690                 695                 700                 


Arg Pro Glu Gln Asp Glu Asn Thr Lys Arg Arg Ile Ser Val Phe Phe 
705                 710                 715                 720 


Val Pro Asp Gly Glu Ala Arg Lys Leu Leu Pro Leu Leu Ile Arg Arg 
                725                 730                 735     


Arg Met Lys Glu Gln Asn Asp Leu Gln Asp Trp Ile Arg Asn Lys Gln 
            740                 745                 750         


Ala His Pro Ile Asp Leu Pro Ser His Leu Phe Asp Ser Lys Val Met 
        755                 760                 765             


Glu Leu Leu Lys Val Lys Asp Gly Lys Lys Lys Trp Asn Glu Ala Phe 
    770                 775                 780                 


Lys Asp Trp Trp Ser Thr Lys Tyr Pro Asp Gly Met Gln Pro Phe Tyr 
785                 790                 795                 800 


Gly Leu Arg Arg Glu Leu Asn Ile His Gly Lys Ser Val Ser Tyr Ile 
                805                 810                 815     


Pro Ser Asp Gly Lys Lys Phe Ala Asp Cys Tyr Thr His Leu Met Glu 
            820                 825                 830         


Lys Thr Val Arg Asp Lys Lys Arg Glu Leu Arg Thr Ala Gly Lys Pro 
        835                 840                 845             


Val Pro Pro Asp Leu Ala Ala Asp Ile Lys Arg Ser Phe His Arg Ala 
    850                 855                 860                 


Val Asn Glu Arg Glu Phe Met Leu Arg Leu Val Gln Glu Asp Asp Arg 
865                 870                 875                 880 


Leu Met Leu Met Ala Ile Asn Lys Met Met Thr Asp Arg Glu Glu Asp 
                885                 890                 895     


Ile Leu Pro Gly Leu Lys Asn Ile Asp Ser Ile Leu Asp Lys Glu Asn 
            900                 905                 910         


Gln Phe Ser Leu Ala Val His Ala Lys Val Leu Glu Lys Glu Gly Glu 
        915                 920                 925             


Gly Gly Asp Asn Ser Leu Ser Leu Val Pro Ala Thr Ile Glu Ile Lys 
    930                 935                 940                 


Ser Lys Arg Lys Asp Trp Ser Lys Tyr Ile Arg Tyr Arg Tyr Asp Arg 
945                 950                 955                 960 


Arg Val Pro Gly Leu Met Ser His Phe Pro Glu His Lys Ala Thr Leu 
                965                 970                 975     


Asp Glu Val Lys Thr Leu Leu Gly Glu Tyr Asp Arg Cys Arg Ile Lys 
            980                 985                 990         


Ile Phe Asp Trp Ala Phe Ala Leu  Glu Gly Ala Ile Met  Ser Asp Arg 
        995                 1000                 1005             


Asp Leu  Lys Pro Tyr Leu His  Glu Ser Ser Ser Arg  Glu Gly Lys 
    1010                 1015                 1020             


Ser Gly  Glu His Ser Thr Leu  Val Lys Met Leu Val  Glu Lys Lys 
    1025                 1030                 1035             


Gly Cys  Leu Thr Pro Asp Glu  Ser Gln Tyr Leu Ile  Leu Ile Arg 
    1040                 1045                 1050             


Asn Lys  Ala Ala His Asn Gln  Phe Pro Cys Ala Ala  Glu Met Pro 
    1055                 1060                 1065             


Leu Ile  Tyr Arg Asp Val Ser  Ala Lys Val Gly Ser  Ile Glu Gly 
    1070                 1075                 1080             


Ser Ser  Ala Lys Asp Leu Pro  Glu Gly Ser Ser Leu  Val Asp Ser 
    1085                 1090                 1095             


Leu Trp  Lys Lys Tyr Glu Met  Ile Ile Arg Lys Ile  Leu Pro Ile 
    1100                 1105                 1110             


Leu Asp  Pro Glu Asn Arg Phe  Phe Gly Lys Leu Leu  Asn Asn Met 
    1115                 1120                 1125             


Ser Gln  Pro Ile Asn Asp Leu  
    1130                 1135 


<210>  1447
<211>  1175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1447

Met Thr Glu Gln Asn Glu Arg Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Phe Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Ala His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Lys Tyr Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Gly Lys Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Ala Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Leu Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Glu Glu Val 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Asp Glu Ile Asp Thr Leu Asp 
    530                 535                 540                 


Arg Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Ile Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Glu Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Ser Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Leu Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asn Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Asp Arg Ala Glu Glu Trp Glu Arg Gly 
            820                 825                 830         


Lys Glu Gln Phe Arg Asp Leu Glu Ala Trp Ser His Gly Ala Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Val Gly Ile Glu Tyr Ala Ser Arg Glu Asn 
    850                 855                 860                 


Lys Lys Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Glu Thr 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Lys Thr Asp Lys Ile Asn Ile Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Ala Lys Glu His Pro Tyr Leu Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asp Ile Arg Thr 
945                 950                 955                 960 


Asp Val Gln Glu Gln Gly Ser Leu Asn Val Leu Asn His Val Lys Pro 
                965                 970                 975     


Met Arg Leu Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val 
            980                 985                 990         


His Lys Glu Gln Ala Pro Leu Ala  Thr Val Tyr Ile Glu  Glu Arg Asp 
        995                 1000                 1005             


Thr Lys  Leu Leu Lys Gln Gly  Asn Phe Lys Ser Phe  Val Lys Asp 
    1010                 1015                 1020             


Arg Arg  Leu Asn Gly Leu Phe  Ser Phe Val Asp Thr  Gly Gly Leu 
    1025                 1030                 1035             


Ala Met  Glu Gln Tyr Pro Ile  Ser Lys Leu Arg Val  Glu Tyr Glu 
    1040                 1045                 1050             


Leu Ala  Lys Tyr Gln Thr Ala  Arg Val Cys Ala Phe  Glu Gln Thr 
    1055                 1060                 1065             


Leu Glu  Leu Glu Glu Ser Leu  Leu Thr Arg Tyr Pro  His Leu Pro 
    1070                 1075                 1080             


Asp Lys  Asn Phe Arg Glu Met  Leu Glu Ser Trp Ser  Asp Pro Leu 
    1085                 1090                 1095             


Leu Asp  Lys Trp Pro Asp Leu  Gln Arg Glu Val Arg  Leu Leu Ile 
    1100                 1105                 1110             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1115                 1120                 1125             


Glu Thr  Leu Phe Ser Ser Ile  Arg Lys Tyr Asp Pro  Ser Ser Pro 
    1130                 1135                 1140             


Asp Ala  Ile Glu Glu Arg Met  Gly Leu Asn Ile Ala  His Arg Leu 
    1145                 1150                 1155             


Ser Glu  Glu Val Lys Gln Ala  Lys Glu Met Ala Glu  Arg Ile Ile 
    1160                 1165                 1170             


Gln Val  
    1175 


<210>  1448
<211>  1135
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1448

Met Asn Thr Val Pro Ala Ser Glu Asn Lys Gly Gln Ser Arg Thr Val 
1               5                   10                  15      


Glu Asp Asp Pro Gln Tyr Phe Gly Leu Tyr Leu Asn Leu Ala Arg Glu 
            20                  25                  30          


Asn Leu Ile Glu Val Glu Ser His Val Arg Ile Lys Phe Gly Lys Lys 
        35                  40                  45              


Lys Leu Asn Glu Glu Ser Leu Lys Gln Ser Leu Leu Cys Asp His Leu 
    50                  55                  60                  


Leu Ser Val Asp Arg Trp Thr Lys Val Tyr Gly His Ser Arg Arg Tyr 
65                  70                  75                  80  


Leu Pro Phe Leu His Tyr Phe Asp Pro Asp Ser Gln Ile Glu Lys Asp 
                85                  90                  95      


His Asp Ser Lys Thr Gly Val Asp Pro Asp Ser Ala Gln Arg Leu Ile 
            100                 105                 110         


Arg Glu Leu Tyr Ser Leu Leu Asp Phe Leu Arg Asn Asp Phe Ser His 
        115                 120                 125             


Asn Arg Leu Asp Gly Thr Thr Phe Glu His Leu Glu Val Ser Pro Asp 
    130                 135                 140                 


Ile Ser Ser Phe Ile Thr Gly Thr Tyr Ser Leu Ala Cys Gly Arg Ala 
145                 150                 155                 160 


Gln Ser Arg Phe Ala Asp Phe Phe Lys Pro Asp Asp Phe Val Leu Ala 
                165                 170                 175     


Lys Asn Arg Lys Glu Gln Leu Ile Ser Val Ala Asp Gly Lys Glu Cys 
            180                 185                 190         


Leu Thr Val Ser Gly Leu Ala Phe Phe Ile Cys Leu Phe Leu Asp Arg 
        195                 200                 205             


Glu Gln Ala Ser Gly Met Leu Ser Arg Ile Arg Gly Phe Lys Arg Thr 
    210                 215                 220                 


Asp Glu Asn Trp Ala Arg Ala Val His Glu Thr Phe Cys Asp Leu Cys 
225                 230                 235                 240 


Ile Arg His Pro His Asp Arg Leu Glu Ser Ser Asn Thr Lys Glu Ala 
                245                 250                 255     


Leu Leu Leu Asp Met Leu Asn Glu Leu Asn Arg Cys Pro Arg Ile Leu 
            260                 265                 270         


Tyr Asp Met Leu Pro Glu Glu Glu Arg Ala Gln Phe Leu Pro Ala Leu 
        275                 280                 285             


Asp Glu Asn Ser Met Asn Asn Leu Ser Glu Asn Ser Leu Asn Glu Glu 
    290                 295                 300                 


Ser Arg Leu Leu Trp Asp Gly Ser Ser Asp Trp Ala Glu Ala Leu Thr 
305                 310                 315                 320 


Lys Arg Ile Arg His Gln Asp Arg Phe Pro Tyr Leu Met Leu Arg Phe 
                325                 330                 335     


Ile Glu Glu Met Asp Leu Leu Lys Gly Ile Arg Phe Arg Val Asp Leu 
            340                 345                 350         


Gly Glu Ile Glu Leu Asp Ser Tyr Ser Lys Lys Val Gly Arg Asn Gly 
        355                 360                 365             


Glu Tyr Asp Arg Thr Ile Thr Asp His Ala Leu Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Asp Phe Gln Asn Glu Glu Glu Val Ser Arg Met Ile Ser Gly Glu 
385                 390                 395                 400 


Ala Ser Tyr Pro Val Arg Phe Ser Leu Phe Ala Pro Arg Tyr Ala Ile 
                405                 410                 415     


Tyr Asp Asn Lys Ile Gly Tyr Cys His Thr Ser Asp Pro Val Tyr Pro 
            420                 425                 430         


Lys Ser Lys Thr Gly Glu Lys Arg Ala Leu Ser Asn Pro Gln Ser Met 
        435                 440                 445             


Gly Phe Ile Ser Val His Asp Leu Arg Lys Leu Leu Leu Met Glu Leu 
    450                 455                 460                 


Leu Cys Glu Gly Ser Phe Ser Arg Met Gln Ser Gly Phe Leu Arg Lys 
465                 470                 475                 480 


Ala Asn Arg Ile Leu Asp Glu Thr Ala Glu Gly Lys Leu Gln Phe Ser 
                485                 490                 495     


Ala Leu Phe Pro Glu Met Arg His Arg Phe Ile Pro Pro Gln Asn Pro 
            500                 505                 510         


Lys Ser Lys Asp Arg Arg Glu Lys Ala Glu Thr Thr Leu Glu Lys Tyr 
        515                 520                 525             


Lys Gln Glu Ile Lys Gly Arg Lys Asp Lys Leu Asn Ser Gln Leu Leu 
    530                 535                 540                 


Ser Ala Phe Asp Met Asn Gln Arg Gln Leu Pro Ser Arg Leu Leu Asp 
545                 550                 555                 560 


Glu Trp Met Asn Ile Arg Pro Ala Ser His Ser Val Lys Leu Arg Thr 
                565                 570                 575     


Tyr Val Lys Gln Leu Asn Glu Asp Cys Arg Leu Arg Leu Arg Lys Phe 
            580                 585                 590         


Arg Lys Asp Gly Asp Gly Lys Ala Arg Ala Ile Pro Leu Val Gly Glu 
        595                 600                 605             


Met Ala Thr Phe Leu Ser Gln Asp Ile Val Arg Met Ile Ile Ser Glu 
    610                 615                 620                 


Glu Thr Lys Lys Leu Ile Thr Ser Ala Tyr Tyr Asn Glu Met Gln Arg 
625                 630                 635                 640 


Ser Leu Ala Gln Tyr Ala Gly Glu Glu Asn Arg Arg Gln Phe Arg Ala 
                645                 650                 655     


Ile Val Ala Glu Leu His Leu Leu Asp Pro Ser Ser Gly His Pro Phe 
            660                 665                 670         


Leu Ser Ala Thr Met Glu Thr Ala His Arg Tyr Thr Glu Asp Phe Tyr 
        675                 680                 685             


Lys Cys Tyr Leu Glu Lys Lys Arg Glu Trp Leu Ala Lys Thr Phe Tyr 
    690                 695                 700                 


Arg Pro Glu Gln Asp Glu Asn Thr Lys Arg Arg Ile Ser Val Phe Phe 
705                 710                 715                 720 


Val Pro Asp Gly Glu Ala Arg Lys Leu Leu Pro Leu Leu Ile Arg Arg 
                725                 730                 735     


Arg Met Lys Glu Gln Asn Asp Leu Gln Asp Trp Ile Arg Asn Lys Gln 
            740                 745                 750         


Ala His Pro Ile Asp Leu Pro Ser His Leu Phe Asp Ser Lys Ile Met 
        755                 760                 765             


Glu Leu Leu Lys Val Lys Asp Gly Lys Lys Lys Trp Asn Glu Ala Phe 
    770                 775                 780                 


Lys Asp Trp Trp Ser Thr Lys Tyr Pro Asp Gly Met Gln Pro Phe Tyr 
785                 790                 795                 800 


Gly Leu Arg Arg Glu Leu Asn Ile His Gly Lys Ser Val Ser Tyr Ile 
                805                 810                 815     


Pro Ser Asp Gly Lys Lys Phe Ala Asp Cys Tyr Thr His Leu Met Glu 
            820                 825                 830         


Lys Thr Val Gln Asp Lys Lys Arg Glu Leu Arg Thr Ala Gly Lys Pro 
        835                 840                 845             


Val Pro Pro Asp Leu Ala Ala Asp Ile Lys Arg Ser Phe His Arg Ala 
    850                 855                 860                 


Val Asn Glu Arg Glu Phe Met Leu Arg Leu Val Gln Glu Asp Asp Arg 
865                 870                 875                 880 


Leu Met Leu Met Ala Ile Asn Lys Met Met Thr Asp Arg Glu Glu Asp 
                885                 890                 895     


Ile Leu Pro Gly Leu Lys Asn Ile Asp Ser Ile Leu Asp Glu Glu Asn 
            900                 905                 910         


Gln Phe Ser Leu Ala Val His Ala Lys Val Leu Glu Lys Glu Gly Glu 
        915                 920                 925             


Gly Gly Asp Asn Ser Leu Ser Leu Val Pro Ala Thr Ile Glu Ile Lys 
    930                 935                 940                 


Ser Lys Arg Lys Asp Trp Ser Lys Tyr Ile Arg Tyr Arg Tyr Asp Arg 
945                 950                 955                 960 


Arg Val Pro Gly Leu Met Ser His Phe Pro Glu His Lys Ala Thr Leu 
                965                 970                 975     


Asp Glu Val Lys Thr Leu Leu Gly Glu Tyr Asp Arg Cys Arg Ile Lys 
            980                 985                 990         


Ile Phe Asp Trp Ala Phe Ala Leu  Glu Gly Ala Ile Met  Ser Asp Arg 
        995                 1000                 1005             


Asp Leu  Lys Pro Tyr Leu His  Glu Ser Ser Ser Arg  Glu Gly Lys 
    1010                 1015                 1020             


Ser Gly  Glu His Ser Thr Leu  Val Lys Met Leu Val  Glu Lys Lys 
    1025                 1030                 1035             


Gly Cys  Leu Thr Pro Asp Glu  Ser Gln Tyr Leu Ile  Leu Ile Arg 
    1040                 1045                 1050             


Asn Lys  Ala Ala His Asn Gln  Phe Pro Cys Ala Ala  Glu Met Pro 
    1055                 1060                 1065             


Leu Ile  Tyr Arg Asp Val Ser  Ala Lys Val Gly Ser  Ile Glu Gly 
    1070                 1075                 1080             


Ser Ser  Ala Lys Asp Leu Pro  Glu Gly Ser Ser Leu  Val Asp Ser 
    1085                 1090                 1095             


Leu Trp  Lys Lys Tyr Glu Met  Ile Ile Arg Lys Ile  Leu Pro Ile 
    1100                 1105                 1110             


Leu Asp  Pro Glu Asn Arg Phe  Phe Gly Lys Leu Leu  Asn Asn Met 
    1115                 1120                 1125             


Ser Gln  Pro Ile Asn Asp Leu  
    1130                 1135 


<210>  1449
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1449

Met Glu Thr Lys Gln Gln Val Gly Lys Gly Ile Ser Tyr Asp His Arg 
1               5                   10                  15      


Arg Pro Asp Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asp Gly Val Ile Gln Glu Phe Ala Met Arg Leu Asn Arg 
        35                  40                  45              


Glu Tyr Asp Pro Glu Asn Lys Asn Gln Ser Leu Phe Ser Tyr Phe Asn 
    50                  55                  60                  


Ile Asn Ala Ser Phe Thr Asp Trp Glu Arg Gly Val Asn Ile Leu Lys 
65                  70                  75                  80  


Glu Tyr Trp Pro Met Met Glu Phe Ile Asp Arg Pro Ala Thr Asp Lys 
                85                  90                  95      


Gln Phe Glu Ala Glu Lys Pro Glu Asn Arg Glu Ala Ala Lys Arg Lys 
            100                 105                 110         


Tyr Phe Leu Ala Thr Leu Gly Ala Leu Leu Thr Ser Ile Lys Asp Leu 
        115                 120                 125             


Arg His Tyr Tyr Thr His Tyr Tyr His Pro Pro Val His Leu Asn Asp 
    130                 135                 140                 


Asp Leu Phe Leu Phe Leu Asp His Ala Leu Leu Tyr Thr Ala Phe Asp 
145                 150                 155                 160 


Val Lys Lys Thr Lys Met Lys Asp Asp Lys Thr Arg Gln Leu Leu Asn 
                165                 170                 175     


Gln Asn Leu Ser Leu Glu Leu Glu Lys Leu Lys Lys Leu Lys Val Glu 
            180                 185                 190         


Glu Leu Lys Lys Lys Lys Glu Lys Gly Ile Lys Val Asn Leu Gln Asp 
        195                 200                 205             


Glu Lys Gly Ile Leu Asn Ala Ile Tyr Asn Asp Ala Phe Ala His Ile 
    210                 215                 220                 


Ile Thr Lys Glu Lys Asp Ser Asp Lys Asp Lys Leu Glu Thr Arg Tyr 
225                 230                 235                 240 


Lys Ser Ile Leu Pro Gln Asp Glu Ala Ala Glu Thr Gly Ile Asn Ile 
                245                 250                 255     


Ser Ile Ser Gly Leu Ile Phe Leu Leu Ser Leu Phe Leu Ser Arg Lys 
            260                 265                 270         


Glu Ile Glu Gln Leu Lys Ser Asn Ile Glu Gly Tyr Lys Gly Lys Val 
        275                 280                 285             


Leu Asn Ile Glu Thr Glu Val Asp Arg Lys His Asn Ser Leu Lys Tyr 
    290                 295                 300                 


Met Ala Thr His Trp Val Phe Ser Ile Leu Ala Phe Lys Gly Leu Lys 
305                 310                 315                 320 


Gln Arg Leu Thr Asn Ser Phe Glu Lys Glu Ser Leu Leu Ile Gln Met 
                325                 330                 335     


Met Asp Glu Leu Asn Lys Val Pro Asp Glu Leu Tyr Gln Thr Leu Ser 
            340                 345                 350         


Glu Thr Ala Lys Lys Glu Phe Leu Glu Asp Ile Asn Glu Tyr Val Ser 
        355                 360                 365             


Glu Gly Asp Asp Asn Glu Lys Ala Thr Tyr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Ser Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gln Phe Pro Thr Leu Lys Phe Gln Ile Phe Val Gly 
                405                 410                 415     


Gln Tyr Leu His Asp Asn Arg Pro Lys Thr Leu Ala Ser Asn Gly Met 
            420                 425                 430         


Thr Ala Gln Arg Met Ile Lys Glu Lys Ile Asn Leu Phe Gly Asn Leu 
        435                 440                 445             


Ser Glu Val Thr Lys His Lys Ser Asp Phe Phe Glu Lys Glu Ser Ala 
    450                 455                 460                 


Ala Gln Gly Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Trp Ala Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Val Tyr Ile Asp Met Ile Gly Lys Glu Gly Lys Ala 
                485                 490                 495     


Lys Glu Ile Gln Val Gln Ile Asn Lys Tyr Arg Lys Gln Leu Asn Pro 
            500                 505                 510         


Ala Pro Gln Arg Asp Lys Arg Ile Ser Lys Lys Glu Ile Ile Glu Gln 
        515                 520                 525             


Leu Tyr Lys Glu Lys Val Val Tyr Gly Asp Pro Thr Leu Met Leu Ser 
    530                 535                 540                 


Ala Asn Glu Leu Met Ala Leu Leu Tyr Glu Leu Ile Val Asn Gly Lys 
545                 550                 555                 560 


Ser Gly Ala Glu Leu Glu Asn Lys Ile Val Glu Gln Ile Ile Ala Arg 
                565                 570                 575     


Tyr Glu Gln Ile Glu Ala Tyr Asp Pro Thr Thr Gln Gln Leu Pro Thr 
            580                 585                 590         


Asn Gln Met Pro His Lys Leu Gln Lys Ser Arg Lys Asp Ser Lys Val 
        595                 600                 605             


Thr Asp Thr Asp Lys Leu Leu Lys Thr Ile Asp Lys Glu Ile Asp Glu 
    610                 615                 620                 


Gly Asn Lys Lys Leu Glu Leu Ile Ala Cys His Arg Lys Glu Trp Glu 
625                 630                 635                 640 


Glu Ala Glu Gln Arg Lys Lys Ser Gly Lys Arg Asn Asn Pro Gly Thr 
                645                 650                 655     


Lys Ser Arg Lys His Leu Phe Tyr Ala Ser Glu Met Gly Glu Glu Ala 
            660                 665                 670         


Thr Trp Ile Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Pro Ala Arg 
        675                 680                 685             


Ala Glu Trp Lys Gly Thr His His Ser Glu Leu Gln Arg Leu Leu Ala 
    690                 695                 700                 


Phe Tyr Ser Thr Gln Arg Leu Glu Ala Trp Gln Leu Val Glu Ser Val 
705                 710                 715                 720 


Trp Thr Ala Asn Thr His Ser Phe Trp Glu Glu Asn Phe Lys Glu Ala 
                725                 730                 735     


Phe Tyr Lys Pro Glu Phe Glu Asn Phe Tyr Gly Ala Tyr Ile Glu Ile 
            740                 745                 750         


Arg Thr Lys Ile Leu Thr Thr Cys Arg Ser Ile Leu Glu Asn Asn Pro 
        755                 760                 765             


Glu Ala Thr Met Asn Asn Asp Thr Glu Lys Glu Trp Asp Lys Val Phe 
    770                 775                 780                 


Thr Leu Phe Asp Lys Arg Leu Tyr Arg Thr Ser Thr Thr Asp Glu Gln 
785                 790                 795                 800 


Lys Lys Gln Leu Leu Thr Lys Pro Phe Ala Phe Pro Arg Gly Leu Phe 
                805                 810                 815     


Asp Asp Lys Pro Thr Phe Leu Pro Gly Ser Lys Pro Asn Glu Asn Pro 
            820                 825                 830         


Glu Arg Phe Ala Ala Trp Tyr Ser Tyr Gly Tyr Thr Tyr Ser Gly Lys 
        835                 840                 845             


Phe Gln Ser Phe Tyr Asp Met Pro Arg Asn Tyr Ser Asp Trp Tyr Lys 
    850                 855                 860                 


Lys Leu Lys Glu Asp Gly Lys Leu Pro Arg Leu Asp Lys Lys Thr Glu 
865                 870                 875                 880 


Gln Glu Lys Ile Leu Arg Phe Arg Met Asp Cys Asp Leu Asn Ile Lys 
                885                 890                 895     


His Ile Arg Phe Gln Asp Ile Tyr Val Lys Leu Met Val Asp Ser Leu 
            900                 905                 910         


Tyr Lys Ala Val Phe Gly Gln Gln Pro Glu Phe Asp Leu Ser His Leu 
        915                 920                 925             


Tyr Asp Thr Arg Ser Glu Arg Tyr Glu Asn Asn Thr Ile Ala Gln Arg 
    930                 935                 940                 


Gln Lys Ser Arg Gln Glu Gly Asp Asn Ser Asp Asn Ala Ile Asn Glu 
945                 950                 955                 960 


Asn Tyr Val Trp Asn Lys Thr Phe Ala Ile Ser Leu Tyr Asn Gly Arg 
                965                 970                 975     


Ile Thr Glu Ser Gln Val Lys Leu Lys Asp Val Gly Lys Phe Arg Arg 
            980                 985                 990         


Phe Ala Thr Asp Pro Arg Val Gln  Thr Leu Ile Ser Tyr  Asp Asp Thr 
        995                 1000                 1005             


Arg Thr  Trp Thr Lys Leu Glu  Ile Glu Asn Glu Leu  Asp Asn Lys 
    1010                 1015                 1020             


Ala Asp  Ala Tyr Glu Pro Ile  Arg Arg Thr Gln Ser  Leu Lys Ala 
    1025                 1030                 1035             


Ile Gln  Gln Leu Glu Lys Asn  Ile Leu Lys Lys Asn  Gly Phe Asn 
    1040                 1045                 1050             


Gly Lys  Gln His Pro Glu Glu  Leu Lys His Asn Gly  Asn Pro Asn 
    1055                 1060                 1065             


Phe Arg  Lys Tyr Ile Ala Asn  Gly Leu Leu Lys His  Arg Thr Asp 
    1070                 1075                 1080             


Ile Arg  Gln Glu Glu Leu Ala  Leu Ile Ser Asp Thr  Glu Phe Gln 
    1085                 1090                 1095             


Glu Ile  Gly Leu Glu Arg Ile  Arg Gln Thr Asn Pro  Leu Ile Gln 
    1100                 1105                 1110             


Lys Ala  Tyr Leu Leu Ile Leu  Leu Arg Asn Lys Phe  Gly His Asn 
    1115                 1120                 1125             


Gln Leu  Pro Asp Gln Glu His  Phe Arg Leu Met Arg  Ser Ile Tyr 
    1130                 1135                 1140             


Pro Tyr  Asn Gln Gln Glu Ser  Tyr Ser Ala Tyr Phe  Asn His Val 
    1145                 1150                 1155             


Ile Thr  Gln Ile Ile Glu Glu  Leu Asn Thr 
    1160                 1165             


<210>  1450
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1450

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Ala Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Asn Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1451
<211>  1081
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1451

Met Gln Ala Gln Ser Leu Phe Asp Glu Tyr Lys His Leu Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Val Met Ser Ile Met Asn Ile Ile Thr Val Leu Asn His Ile 
            20                  25                  30          


His Gln Ile Ala Gly Leu Lys Arg Asn Glu Leu Gly Asp Asp Asp Asn 
        35                  40                  45              


Ile Tyr Ser His Pro Val Leu Lys Tyr Ile Ala Pro Glu Asn Asn Ser 
    50                  55                  60                  


Thr Thr Leu Pro Glu Lys Arg Asp Leu Ile Lys Glu Leu Leu Leu Glu 
65                  70                  75                  80  


Tyr Leu Pro Phe Leu Glu Ala Met Lys Asp Cys Tyr Lys Glu Val Lys 
                85                  90                  95      


Val Glu Lys Asp Lys Arg Asn Asn Lys Tyr Val Lys Asp Lys Lys Gln 
            100                 105                 110         


Val Phe Ile Arg Asn Tyr Ser Asp Ile Tyr Cys Ile Tyr Trp Thr Leu 
        115                 120                 125             


Tyr Asn Ile Phe Ser Thr Leu Ile Asn Tyr Arg Asp Lys Ser Cys His 
    130                 135                 140                 


Tyr Arg Phe Ile Pro Ser Lys Asp Gln Glu Glu Tyr Ser Lys Arg Thr 
145                 150                 155                 160 


Glu Tyr Asp Thr Val Arg Ile Ile Asn Lys Tyr Tyr Thr Tyr Ala Leu 
                165                 170                 175     


Arg Lys Thr Lys Glu Lys Tyr Gly Tyr Thr Thr Glu Gln Leu Ser Phe 
            180                 185                 190         


Ile Gln Asn Asn Arg Tyr Thr Asp Asp Lys Lys Val Asn Phe Asn Phe 
        195                 200                 205             


Phe Leu Ser Met Gln Ser Ser Asn Asn Asn Leu Ser His Val Gly Val 
    210                 215                 220                 


Ala Gln Leu Ile Cys Leu Phe Leu Gln Lys Lys Asp Val Asp Asn Phe 
225                 230                 235                 240 


Leu Glu Asn Leu Pro Ile Tyr Asp Asn Arg Tyr Cys Leu Gly Ile Asp 
                245                 250                 255     


Glu His Met Ile Ile Lys Arg Ser Leu Ala Leu His Ser Ile Lys Leu 
            260                 265                 270         


Pro Lys Glu Arg Leu Asn Ser Glu Lys Lys Asp Met Ala Ile Ala Met 
        275                 280                 285             


Asp Met Leu Asn Glu Leu Lys Arg Cys Pro Lys Glu Leu Phe Asn Thr 
    290                 295                 300                 


Leu Pro Phe Asp Lys Gln Glu Arg Phe Arg Ile Ile Ser Ser Asp His 
305                 310                 315                 320 


Lys Glu Val Leu Leu Met Arg Ser Thr Asp Arg Phe Val Pro Leu Ile 
                325                 330                 335     


Leu Gln Tyr Ile Asp Cys Asn Lys Lys Phe Lys Asp Ile Arg Phe His 
            340                 345                 350         


Val Asn Met Gly Lys Leu Arg Tyr Leu Phe Ser Pro Asn Lys Leu Cys 
        355                 360                 365             


Ile Asp Asn Gln Glu Arg Val Arg Met Leu Glu His Leu Leu Asn Gly 
    370                 375                 380                 


Tyr Gly Arg Ile Asp Glu Val Glu Tyr Leu Arg Lys Ala Pro Asn Gly 
385                 390                 395                 400 


Thr Phe Gly Asn Thr Asn Ile Pro Ile Lys Gly Phe Gly Glu Ile Glu 
                405                 410                 415     


Arg Asp Ser Ala Asp Ser Asn Asn Tyr Pro Tyr Ile Val Asp Thr His 
            420                 425                 430         


Thr His Tyr Ile Leu Asn Asn Asn Lys Val Glu Phe Cys Phe Cys Glu 
        435                 440                 445             


Asp Ser Lys Asn Lys Asn Val Phe Pro Thr Ile Glu Lys Glu Ile Asn 
    450                 455                 460                 


Gly Lys Trp Tyr Val Glu Lys Thr Ala Pro His Cys Arg Ile Ser Phe 
465                 470                 475                 480 


Phe Glu Ile Pro Ala Met Ala Phe His Met Phe Leu Cys Gly Ser Glu 
                485                 490                 495     


Lys Thr Glu Lys Leu Ile Lys Asp Val Tyr Asn Asn Tyr Ile Ser Leu 
            500                 505                 510         


Phe Asn Ala Leu Lys Asn Gly Ala Leu Thr Glu Glu Asn Tyr Lys Asp 
        515                 520                 525             


Phe Asn Ile Pro Glu Cys Asp Met Pro Lys Lys Ile Leu Asp Phe Leu 
    530                 535                 540                 


Lys Gly Lys Ala Glu Gly Lys Ser Ile Asp Gly Tyr Val Lys Asn Ile 
545                 550                 555                 560 


Leu Lys Lys Glu Leu Lys Asp Thr Arg Lys Arg Ile Glu Gln Ala Pro 
                565                 570                 575     


Ser Glu Lys Asp Gln Met Pro Ser Lys Arg Asn Lys Ile Gly Thr Lys 
            580                 585                 590         


Ser Tyr Lys Arg Val Leu Thr Gly Lys Leu Ala Asp Phe Leu Ala Lys 
        595                 600                 605             


Asp Ile Val Lys Tyr Gln Pro Thr Leu Cys Ala Gly Asp Asp Tyr Gly 
    610                 615                 620                 


Ile Asp Arg Met Thr Gly Met Asn Tyr Arg Ile Met Gln Ala Thr Ile 
625                 630                 635                 640 


Ala Thr Tyr Asn Asp Asp Asp Asp Phe Asp Thr Phe Tyr Asn Val Phe 
                645                 650                 655     


Lys Met Ala Gly Leu Val Asp Gly Asp Glu Arg Lys Asn His Pro Phe 
            660                 665                 670         


Leu Lys Lys Val Leu Leu Ser Lys Pro Gln Asn Thr Val Ala Phe Asn 
        675                 680                 685             


Ile Lys Tyr Leu Lys Glu Lys Glu Ile Tyr Leu Arg Asn Ile Glu Lys 
    690                 695                 700                 


Lys Asn Ile Ile Pro Pro Phe Val Asn Arg Glu Arg Asn Lys Trp Cys 
705                 710                 715                 720 


Glu Arg Asp Cys Glu Tyr Tyr Arg Ile Leu Gly Glu Asn Leu Leu Asp 
                725                 730                 735     


Leu Pro Ile Glu Leu Pro Arg Gln Met Phe Tyr Lys Asp Ile Arg Ala 
            740                 745                 750         


Gln Leu Glu Pro Leu Met Pro Glu Ile Asp Phe Ser Gln Thr Asn Thr 
        755                 760                 765             


Thr Tyr Leu Ile Ala Glu Tyr Leu Lys Arg Val Arg Gly Asp Asp Phe 
    770                 775                 780                 


Gln Glu Phe Tyr Ser Trp Glu Arg Asn Tyr Arg Tyr Ile Asp Phe Leu 
785                 790                 795                 800 


Lys Cys Ile Arg Asp Asp Asn Gly Arg Ile Cys Ala Gln Tyr Thr Thr 
                805                 810                 815     


Thr Glu Glu Arg Glu Ser Leu Trp Glu Asp Ser Lys Asn Arg Thr Ala 
            820                 825                 830         


Glu Tyr Lys Arg Ser Glu Glu Gln Lys Asn Glu Lys Lys Asp Lys Asn 
        835                 840                 845             


Phe Glu Asp Ser Leu Glu Glu Arg Ile Ser Ser Ser His Ile Lys Phe 
    850                 855                 860                 


Gln Asn Thr Glu Lys His Ile Arg Arg Tyr Lys Val Gln Asp Ala Leu 
865                 870                 875                 880 


Leu Phe Met Ile Ala Glu Lys Gln Phe Gly Lys Tyr Leu Asp Asp Ile 
                885                 890                 895     


Lys Ala Lys Asn Phe Lys Leu Lys Asp Ile Met Pro Asp Thr Asp Lys 
            900                 905                 910         


Gly Ile Leu Ser Glu Thr Met Pro Ile Asp Phe Thr Phe Thr Lys Lys 
        915                 920                 925             


Asn Ile Lys Tyr Asn Ile His Ala Lys Asn Leu Lys Phe Lys Glu Tyr 
    930                 935                 940                 


Gly Asp Leu Phe Ile Leu Ala Asn Asp Lys Arg Leu Glu Ser Leu Trp 
945                 950                 955                 960 


Lys Ile Leu Ala Thr Asp Thr Val Asn Lys Glu Glu Ile Ser Glu Glu 
                965                 970                 975     


Phe Ala Lys Tyr Asp Phe Cys Arg Pro Asp Ile Thr Lys Leu Val Leu 
            980                 985                 990         


Asp Phe Glu Lys Asp Val Leu Glu  Lys Tyr Pro Glu Ile  Ile Glu Glu 
        995                 1000                 1005             


Ala Glu  Lys Glu Tyr Lys Lys  Phe Asp Phe Lys Phe  Ile Leu Asp 
    1010                 1015                 1020             


Trp Leu  Ile Asn Lys Lys Lys  Leu Asn Tyr Gly Ile  Arg Asn Lys 
    1025                 1030                 1035             


Leu Leu  Leu Ile Arg Asn Ala  Phe Asn His Asn Ser  Tyr Pro Asp 
    1040                 1045                 1050             


Lys Lys  Tyr Ala Glu Val Arg  Glu Leu Pro Glu Ile  Ala Thr Asn 
    1055                 1060                 1065             


Leu Lys  Lys Thr Phe Asp Glu  Asn Ala Lys Lys Tyr  Glu 
    1070                 1075                 1080     


<210>  1452
<211>  1008
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1452

Met Asp Thr Pro Asn Phe Ser Glu Arg Ile Pro Val Ser Leu Gln Ser 
1               5                   10                  15      


His Pro Tyr Tyr Phe Ala His Tyr Leu Asn Met Ala Arg His Asn Ala 
            20                  25                  30          


Tyr Val Ile Leu Glu Tyr Val Asn Arg Glu Leu Ile Lys Pro Gly Lys 
        35                  40                  45              


Asn Leu Asp Glu Asp Asn Leu Ile Gln Ser Thr Val Leu Lys Asp Gly 
    50                  55                  60                  


Tyr Phe Asp Arg Lys Pro Asp Glu Leu Ser His Arg Asn Arg Leu Leu 
65                  70                  75                  80  


Val Gln His Phe Pro Phe Leu Arg Glu Ala Glu Asn Glu Gly Ala Arg 
                85                  90                  95      


Thr Cys Asn Pro Val Ser Tyr Lys Leu Lys Thr Ala Leu Ala Ala Leu 
            100                 105                 110         


Asn Gln Trp Arg Asn Asn Ala Ser His Tyr Pro Leu Asn Gln Asn His 
        115                 120                 125             


Glu Lys Asp Phe Asp Leu Gln Pro Phe Phe Ser Phe Ala Ile Glu Ala 
    130                 135                 140                 


Cys Lys Lys Arg Met Arg Glu Val Phe Gln Pro Asp Asp Phe Tyr Leu 
145                 150                 155                 160 


Leu Glu Thr Asn Glu Lys Gln Phe Tyr Thr Leu His Asn Glu Asn Gly 
                165                 170                 175     


Phe Thr Glu Lys Gly Leu Tyr Cys Phe Ile Cys Phe Phe Leu Glu Lys 
            180                 185                 190         


Lys Tyr Ala Phe Gln Phe Leu Ala Gly Ile Lys Gly Phe Lys Asn Thr 
        195                 200                 205             


Thr Asp Asn Lys Phe Arg Ala Thr Leu Glu Thr Phe Thr Glu His Cys 
    210                 215                 220                 


Cys Arg Leu Pro Lys Pro Lys Leu Asp Ser Ser Asp Ile Lys Leu Asp 
225                 230                 235                 240 


Met Leu Gly Glu Leu Ser Arg Cys Pro Ala Pro Leu Phe Asp Leu Leu 
                245                 250                 255     


Asp Ile Glu Glu Arg Lys Lys Phe Ile Arg Glu Pro Glu Glu Val Lys 
            260                 265                 270         


Pro Asp Glu Ser Gly Asp Arg Glu Glu Val Gln Gln Val Leu Met Lys 
        275                 280                 285             


Arg Tyr Asp Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Glu Glu 
    290                 295                 300                 


Lys Asn Leu Leu Lys Gly Ile Ser Phe His Ile His Ile Gly Arg Trp 
305                 310                 315                 320 


Ile Lys Ser Glu His Thr Lys Lys Ile Met Gly Ala Glu Arg Asp Arg 
                325                 330                 335     


Arg Leu Leu Lys Asp Ile Arg Thr Phe Gly Glu Leu Lys Glu Phe Ser 
            340                 345                 350         


Pro Glu His Ala Pro Asp Tyr Trp Leu Arg Asp Gly Ile Thr Pro Asp 
        355                 360                 365             


Asp Val Asp Gln Phe Ser Pro Gln Tyr Arg Ile Val Gly Asn Arg Ile 
    370                 375                 380                 


Gly Ile Lys Leu Asn Tyr Asn Gly His Asn Arg Trp Ser Val Pro Asp 
385                 390                 395                 400 


Lys Glu Ile Asn Val Lys Pro Asp Ala Ile Ile Ser Thr Tyr Glu Phe 
                405                 410                 415     


Leu Asn Leu Phe Leu Tyr Glu His Leu Tyr Gln Lys Lys Leu Thr Gly 
            420                 425                 430         


Leu Ser Pro Ala Glu Phe Ile Gln Asp Tyr Leu Asp Arg Phe Asn Asn 
        435                 440                 445             


Phe Leu Ser Glu Phe Lys Ala Gly His Ile Arg Pro Val Gly Asp Phe 
    450                 455                 460                 


Ser Leu Glu Lys Arg Arg Gly Gln Gly Asp Glu Pro Asp Leu Thr Ala 
465                 470                 475                 480 


Arg Arg Lys Ser Leu Gln Lys Glu Leu Asp Arg Phe Val Leu Lys Gly 
                485                 490                 495     


Lys Asp Leu Pro Asp Lys Ile Arg Glu Tyr Leu Leu Gly Tyr Lys Gln 
            500                 505                 510         


Lys Ser Glu Lys Lys Gln Ala Lys Trp Ile Leu Gly Gly Met Ile Lys 
        515                 520                 525             


Glu Thr Val Tyr Trp Arg Asn Lys Ala Glu Gln Ser Pro Glu Lys Met 
    530                 535                 540                 


Arg Ser Gly Asp Met Ala Gln Gln Leu Ala Arg Asp Ile Ile Phe Leu 
545                 550                 555                 560 


Thr Pro Pro His Thr Val Lys Glu His Lys Gln Lys Leu Asn Ser Leu 
                565                 570                 575     


Glu Tyr Asp Val Leu Gln Tyr Ala Leu Ala Tyr Phe Ser Ser Asn Arg 
            580                 585                 590         


Glu Lys Leu Tyr Ser Phe Phe Lys Glu His Gln Leu Thr Val Lys Gly 
        595                 600                 605             


Asp Arg Ala His Pro Phe Leu Tyr Lys Ile Arg Leu Asp Glu Cys Gln 
    610                 615                 620                 


Gly Ile Leu Asp Phe Phe Ile Val Tyr Met Gln Gln Lys Glu Lys Trp 
625                 630                 635                 640 


Leu Gly Trp Leu Asp Arg Asn Leu Lys Ser Pro Arg Leu Asn Glu Glu 
                645                 650                 655     


Glu Phe Phe Asn Thr Tyr Ser Tyr Phe Ile Lys Thr Asp Thr Lys Arg 
            660                 665                 670         


Ala Ile Glu Met Asp Tyr Glu Ser Cys Pro Asn Tyr Leu Pro Arg Gly 
        675                 680                 685             


Ile Phe Asn Glu Pro Ile Ala Lys Ala Leu Gln Lys Ala Gly Val Lys 
    690                 695                 700                 


Ile Lys Asp Glu Asp Asn Ala Ser Tyr Ala Leu Ser Val Tyr Ser Asn 
705                 710                 715                 720 


Gly Lys Thr Gln Pro Phe Tyr Asn Lys Glu Arg Tyr Tyr Asn Lys Gly 
                725                 730                 735     


Ile Phe Arg Met Glu Glu Leu Pro Glu Lys Leu Gln Pro Lys Glu Leu 
            740                 745                 750         


Leu Gly Lys Ile Gln Trp Thr Ile Lys Ser Ser Gly Lys Asp Thr Glu 
        755                 760                 765             


Glu Phe Arg Ser Leu Gln Asn Leu Lys Asn Arg Ile Leu Asn Thr Glu 
    770                 775                 780                 


Lys Glu Ile Arg Tyr Val Gln Ser Thr Asp Arg Ala Leu Trp Ile Met 
785                 790                 795                 800 


Val Ala Asp Leu Phe Pro Glu Thr Phe Glu Leu Arg Pro Asp Asp Leu 
                805                 810                 815     


Glu Cys Ile Gly His Asp Leu Ser Asp Asp Leu Leu Ser Arg Pro Tyr 
            820                 825                 830         


Gln Met Lys Glu Lys Val Tyr Asn Tyr Thr Ile Thr Asp Tyr Leu Pro 
        835                 840                 845             


Ile Lys Arg Tyr Gly Glu Phe Arg Arg Phe Leu Lys Asp Arg Arg Leu 
    850                 855                 860                 


Glu Asn Leu Leu Thr Tyr Phe Glu Glu Gly Val Pro Leu His Arg Glu 
865                 870                 875                 880 


Ala Leu Val Ala Glu Leu Glu Ala Tyr Asp Leu Gln Arg Lys Asn Leu 
                885                 890                 895     


Leu Glu Ile Ile Tyr Arg Phe Glu Lys Leu Val Phe Asp Arg His Arg 
            900                 905                 910         


His Glu Leu Thr Phe Ser Gly Glu Gly Glu Asn Gln Tyr Val Asn His 
        915                 920                 925             


Trp Asp Tyr Leu Asp Phe Val Ala Arg Lys Tyr Gly Leu Ser Ala Glu 
    930                 935                 940                 


Val Lys Glu Leu Asn Ser Glu Arg Phe Thr Glu Leu Arg Asn Lys Met 
945                 950                 955                 960 


Leu His Asn Gln Ile Pro Tyr Gln Leu Trp Ile Lys Glu Ala Ile Ala 
                965                 970                 975     


Ala Arg Glu Glu Asn Thr Val Cys Gly Arg Ile Met Gly Met Ile Gly 
            980                 985                 990         


Glu Ile Tyr Glu Arg Met Thr Thr  Glu Ile Glu Lys Gln  Met Gln Val 
        995                 1000                 1005             


<210>  1453
<211>  1085
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1453

Met Lys Lys Glu Leu Asn Arg Glu Asp Val Phe Thr Gly Gly Lys Thr 
1               5                   10                  15      


Pro Glu Leu Thr Ile Tyr Tyr Asn Ile Ala Tyr Phe Arg Met Ala Gly 
            20                  25                  30          


Leu Ile Asn Ala Leu Cys Gly Asn Lys Leu Glu Arg Asp Lys Asp Ala 
        35                  40                  45              


Leu Glu Gln Phe Met Lys Ala Phe Ile Asn Gly Lys Gln Lys Leu Thr 
    50                  55                  60                  


Asp Met Gln Phe Val Lys Leu Cys Asp Tyr Leu Trp Lys Gly Tyr Lys 
65                  70                  75                  80  


Tyr Asp Lys Asn Arg Ser Glu Tyr Ser Leu Thr Glu Asn Asp Lys Thr 
                85                  90                  95      


Met Val Leu Lys Met Val Ala Lys Leu Gln Asp Ile Arg Asn Phe Gln 
            100                 105                 110         


Ser His Ile Trp His Asp Asn Lys Val Leu Val Phe Asp Ala Asp Leu 
        115                 120                 125             


Val Gln Phe Ile Lys Asn Lys His Leu Glu Ala Ile Asp Ala Gln Arg 
    130                 135                 140                 


Gln Arg Phe Ser Lys Glu Thr Glu Val Tyr Glu Lys Glu Asn Arg Glu 
145                 150                 155                 160 


Leu Lys Lys Lys Lys Asn Lys Glu Leu Leu Phe Asp Ile His Asp Gly 
                165                 170                 175     


Leu Gly Tyr Ile Thr Gly Glu Gly Arg Asn Phe Phe Leu Ser Phe Phe 
            180                 185                 190         


Leu Thr Arg Gly Glu Met Thr Arg Phe Leu Lys Gln Arg Lys Gly Cys 
        195                 200                 205             


Lys Arg Asp Asp Thr Pro Glu Tyr Lys Ile Lys His Leu Val Tyr Arg 
    210                 215                 220                 


His Phe Thr His Arg Asp Gly Ala Thr Arg Thr His Tyr Gly Tyr Glu 
225                 230                 235                 240 


Asp Asn Met Leu Asp Gln Leu Pro Asp Lys Gln Glu Phe Leu Thr Thr 
                245                 250                 255     


Arg His Thr Tyr Arg Leu Ile Asn Tyr Leu Asn Asp Ile Pro Glu Glu 
            260                 265                 270         


Val Thr Asn Pro Glu Leu Phe Pro Leu Phe Asn Thr Ile Ser Asn Gly 
        275                 280                 285             


Ile Leu Ile Lys Glu Ser Val Gly Thr Tyr Ile Ala Phe Ile Asn Lys 
    290                 295                 300                 


Met Pro Leu Leu Ser Asp Phe Glu Phe Ser Glu Val Trp Gly Lys Asp 
305                 310                 315                 320 


Gly Lys Pro Tyr Thr Asn Leu Val Glu Phe Tyr His Lys Thr Gln Pro 
                325                 330                 335     


Gly Phe Lys Phe Arg Thr Asp Leu Asn Ser Phe His Lys Ile Ile Leu 
            340                 345                 350         


Asn Leu Ile Arg Asp Glu Asn Tyr Thr Gly Phe Phe Thr Thr Gln Leu 
        355                 360                 365             


Asn Leu Phe Met Ala His Arg Glu Glu Leu Ile Leu Val Ile Ser Lys 
    370                 375                 380                 


Pro Leu Ile Thr Pro Asn Asp Leu Leu Leu Ile Glu Glu His Tyr Arg 
385                 390                 395                 400 


Tyr Lys Leu Lys Ala Asn Asp Phe Val Arg Glu Lys Leu Gly Glu Trp 
                405                 410                 415     


Lys Glu Lys Ile Glu Lys Gly Lys Trp Glu Lys Ala Asn Glu Gln Lys 
            420                 425                 430         


Asp Lys Leu Ile Asn Leu Leu Gly Gly Val Ile Glu Ile Thr Phe Tyr 
        435                 440                 445             


Asp Phe Tyr Trp Gln Lys Asp Glu Lys Pro Arg Asn Glu Asn Arg Phe 
    450                 455                 460                 


Met Glu Phe Ala Ile Arg Phe Met Ala Asp Phe Asn Leu Leu Pro Asp 
465                 470                 475                 480 


Cys Glu Trp Glu Val Glu Pro Leu Gln Ile Glu Asn Asp Leu Ile Ala 
                485                 490                 495     


Asn Arg Thr Ala Thr Pro Asp Leu Lys Lys Ser Gly Ser Gln Phe Met 
            500                 505                 510         


Asn Gln Leu Thr Asp Asn Tyr Arg Leu Lys Phe Asn Asp Gly Gln Ile 
        515                 520                 525             


Ala Phe Arg Tyr Gln Asn Gln Val Phe Ile Met Gly His Lys Ala Val 
    530                 535                 540                 


Lys Asn Leu Leu Ile Ala Cys Phe Asp Gly Lys Glu Lys Met Leu Asn 
545                 550                 555                 560 


Gly Phe Met Pro Ala Leu Leu Ala Asp Leu Lys Lys Ile Thr Asn Glu 
                565                 570                 575     


His Ile Leu Lys Asn His Gln Ala Leu Asn Thr Leu Ser Leu Leu Asn 
            580                 585                 590         


Asn Asp Ser Ile Pro Ser Tyr Ile Ser Arg Gln Trp Gly Glu Ala Glu 
        595                 600                 605             


Pro Ile Thr Asp Met Lys Lys Lys Ala Ile Ala Arg Met Asp Tyr Ile 
    610                 615                 620                 


Thr Gln Gln Phe Glu Ala Leu Ile Glu Asn His His Tyr Leu Asn Arg 
625                 630                 635                 640 


Ala Asp Lys Asn Arg Gln Ile Met Arg Cys Tyr Lys Phe Phe Glu Trp 
                645                 650                 655     


Gln Tyr Pro Gln Asn Ser Gln Phe Lys Phe Leu Arg Arg Asn Glu Tyr 
            660                 665                 670         


His Arg Met Ser Ile Tyr His Tyr Cys Leu Asp Lys Glu Gln His Lys 
        675                 680                 685             


Tyr Asp Lys Lys Gly His Asn Tyr Leu Tyr Asn Arg Leu Ile Lys Glu 
    690                 695                 700                 


Ser His Asn Glu Ser Gly Asn Ile Glu Gln His Leu Pro Tyr Gln Ile 
705                 710                 715                 720 


Arg Thr Met Leu Asn Asp Ala Lys Asp Phe Asn Asp Tyr Phe Leu Arg 
                725                 730                 735     


Ile Leu Asn Ala Thr His Lys Ile Leu Thr Asp Trp Lys Asn Gln Leu 
            740                 745                 750         


Lys Gln Gly Arg Glu Pro Asn Asn Tyr Tyr Leu Ser Arg Leu Gly Phe 
        755                 760                 765             


Thr Gly Gly Leu Thr Gln Lys Val Val His Thr Arg Leu Leu Pro Phe 
    770                 775                 780                 


Ser Ile His Pro Gly Ile Pro Val Ser Phe Phe Tyr Arg Thr Glu Met 
785                 790                 795                 800 


Asn Gln Asn Pro Ser Phe Asn Leu Ser Ala Lys Val Trp Asn Ser Glu 
                805                 810                 815     


Ser Pro Phe Arg Val Gly Leu Lys Glu Ser Asn Tyr Gln Tyr Ala Lys 
            820                 825                 830         


Tyr Leu Gly Leu Phe Asn Glu Ile Lys Thr Gln Arg Lys Ile Ile Gly 
        835                 840                 845             


Lys Met Asn Gln Leu Ile Ala Glu Asp Ala Leu Leu Trp Gln Ile Ala 
    850                 855                 860                 


Lys Lys Tyr Leu Asp Lys Cys His Pro Lys Phe Ser Glu Ile Ile Asn 
865                 870                 875                 880 


Gln Gln Val Asn Gly Lys Gln Pro Leu Asn Val Lys Ala Ile His Asp 
                885                 890                 895     


Thr Glu Leu Thr Ile Asp Phe Pro Val Asp Lys Asn Leu Tyr Gln Val 
            900                 905                 910         


Val Val Lys Met Lys Gln Leu Asp Asp Phe Met Phe Ile Asp Ser Lys 
        915                 920                 925             


Pro Val Leu Glu Lys Thr Ile Arg Tyr Met Ile Lys Asn Ser Leu Arg 
    930                 935                 940                 


Asp Lys Glu Tyr Gln Gln Arg Val Phe Ile Glu Thr Asn Pro Gly Val 
945                 950                 955                 960 


Phe Lys Ile Pro Tyr Asn Glu Val Val Glu Ala Met Arg Thr Ile Asn 
                965                 970                 975     


His Gln Ala Leu Thr Trp Ala Arg Leu Leu Leu Asp Trp Glu Ser Lys 
            980                 985                 990         


Thr Val Lys Thr Ile Pro Glu Ala  Asp Lys Lys Ala Lys  Leu Gln Glu 
        995                 1000                 1005             


Ala Tyr  Asn Lys Arg Gln Pro  Ala Phe Phe Asn Phe  Asn Asp Ile 
    1010                 1015                 1020             


Cys Arg  Tyr Ala Asp Asp Gly  Lys Gln Leu Lys Asp  Leu Arg Asn 
    1025                 1030                 1035             


Lys Thr  Phe His Thr Glu Val  Pro Glu Thr Trp Thr  Tyr Asp Glu 
    1040                 1045                 1050             


Met Arg  Glu Asn Lys Thr Ile  Lys Met Val Leu Gly  Ile Asn Glu 
    1055                 1060                 1065             


Thr Thr  Phe Leu Lys Lys Asp  Tyr Ala Ile Glu Asn  Ala Arg Thr 
    1070                 1075                 1080             


Ile Glu  
    1085 


<210>  1454
<211>  1103
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1454

Met Glu Asn Gln Glu Leu Lys Thr Arg Thr Met Lys Ser Glu Pro Tyr 
1               5                   10                  15      


Tyr Tyr Gly Ala Phe Leu Asn Met Ala Arg Leu Asn Ile Phe Asn Ile 
            20                  25                  30          


Ser Asn His Leu Ser Asn Lys Leu Asn Ile Leu Pro Thr Leu Ser Ser 
        35                  40                  45              


Glu Glu His Ile Ala Asn Ala Phe Phe Thr Asp Lys Asn Thr Lys Ile 
    50                  55                  60                  


Lys Trp Glu His Thr Tyr Asp Ile Leu Arg Arg Phe Ile Pro Ile Val 
65                  70                  75                  80  


Lys Val Phe Asp Thr Glu Ser Leu Pro Lys Gly Glu Val Gly Asn Asn 
                85                  90                  95      


Thr Gly Lys Asp Phe Ser Lys Met Ser Asp Thr Leu Lys Ile Ile Phe 
            100                 105                 110         


Lys Glu Leu Asn Glu Phe Arg Asn Asp Tyr Ser His Tyr Tyr Ser Thr 
        115                 120                 125             


Glu Lys Glu Asp Lys Arg Lys Ile Thr Ile Ser Asp Glu Leu Ala Asn 
    130                 135                 140                 


Phe Leu Asn Glu Asn Phe Lys Arg Ala Ile Ala Tyr Thr Lys Lys Arg 
145                 150                 155                 160 


Phe Lys Gly Val Phe Thr Glu Lys Asp Phe Glu Leu Ala Asn Asn Ile 
                165                 170                 175     


Gln Leu Phe Asn Lys Asp Lys Glu Ile Thr Glu Phe Leu Glu Arg Glu 
            180                 185                 190         


Tyr Ala Phe Gln Phe Ile Ser Lys Ile Glu Gly Leu Lys Gly Thr Gln 
        195                 200                 205             


Lys Ser Glu Tyr Arg Ala Thr Arg Glu Val Phe Met Ala Tyr Cys Val 
    210                 215                 220                 


Asn Leu Pro His Asp Lys Phe Ile Ser Glu Asp Ala Lys Gln Ser Phe 
225                 230                 235                 240 


Ser Leu Asp Ile Ile Ser Glu Leu Asn Arg Cys Pro Gln Thr Leu Phe 
                245                 250                 255     


Asn Val Ile Thr Glu Lys Glu Gln Glu Lys Phe Arg Pro Thr Ile Asn 
            260                 265                 270         


Gln Gln Glu Lys Asn Asn Ile Ile Asn Asn Ser Val Pro Tyr Asp Ile 
        275                 280                 285             


Glu Asp Tyr Glu Glu Tyr Val Asn Ser Ile Thr Lys Lys Ile Arg Tyr 
    290                 295                 300                 


Asp Asn Arg Phe Pro Phe Phe Ala Leu Lys Phe Ile Asp Glu Thr Gln 
305                 310                 315                 320 


Val Phe Glu Lys Ile Arg Phe Gln Ile Asp Leu Gly Glu Ile Leu Leu 
                325                 330                 335     


Asp Glu Tyr Thr Lys Gln Leu Ala Asn Asn Glu Glu Lys Arg Gln Val 
            340                 345                 350         


Val Gln Asn Ala Lys Ala Phe Gly Arg Leu Asn Asp Phe Ile Asp Glu 
        355                 360                 365             


Asn Asn Val Leu Glu Asn Ile Asn Lys Gln Asn Gly Ser Ala Ser Phe 
    370                 375                 380                 


Ile Gln Tyr Ala Pro Asn Tyr Asn Phe Asp Asn Asn Lys Ile Gly Ile 
385                 390                 395                 400 


Asp Thr Thr Gly Lys Arg Ile Met Pro Ile Leu Thr Lys Gln Thr Asp 
                405                 410                 415     


Asn Asn Lys Lys Val Lys Asn Lys Leu Lys Gln Pro Leu Pro Lys Ala 
            420                 425                 430         


Phe Leu Ser Ile His Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
        435                 440                 445             


Glu Lys Gly Lys Ala Glu Lys Leu Ile Asn Asp Phe Leu Leu Ile Asn 
    450                 455                 460                 


Glu Ser Gln Leu Leu Asn Tyr Lys Tyr Ile Glu Glu Ile Lys Asn Lys 
465                 470                 475                 480 


Leu Asn Asn Phe Asp Val Phe Gln Lys Arg Ser Gln Arg Lys Lys Leu 
                485                 490                 495     


Gln Thr Ala Tyr Asn Lys Thr Asn Ile Glu Glu Leu Gln Ser Arg Lys 
            500                 505                 510         


Glu Glu Leu Asn Lys Ile Leu Lys Glu Tyr Lys Leu Asn Asp Lys Gln 
        515                 520                 525             


Ile Pro Thr Arg Ile Leu Glu Tyr Trp Leu Asn Ile Glu Asp Val Thr 
    530                 535                 540                 


Pro Asn Glu Ala Ile Ser Asp Arg Ile Lys Leu Met Lys Arg Asp Cys 
545                 550                 555                 560 


Val Asp Arg Leu Arg Asp Ile Lys Lys Gly Lys Ala Pro Lys Ile Gly 
                565                 570                 575     


Glu Met Ala Thr Phe Ile Ala Lys Asp Ile Val Asp Met Ile Ile Ser 
            580                 585                 590         


Lys Asp Ile Lys Gln Lys Ile Ser Ser Phe Tyr Tyr Asp Lys Ile Gln 
        595                 600                 605             


Glu Cys Leu Ala Leu Tyr Asn Val Ser Glu Lys Arg Asp Leu Phe Leu 
    610                 615                 620                 


Thr Ile Cys Asn Glu Leu Arg Leu Leu Asp Ala Asp Lys Gly His Pro 
625                 630                 635                 640 


Phe Leu Lys Asn Ile Asn Leu Asn Arg Ile Asn Tyr Thr Ser Asp Phe 
                645                 650                 655     


Tyr Val Lys Tyr Leu Gln Glu Lys Gly His Lys Leu Ile Lys Glu Thr 
            660                 665                 670         


Asn Tyr Arg Thr Gly Lys Leu Val Glu Lys Asp Lys Ser Trp Met Phe 
        675                 680                 685             


Leu Asn Phe Tyr Tyr Leu Lys Lys Asn Glu Thr Leu Asn Lys Met Met 
    690                 695                 700                 


Thr Ile Val Gln Leu Pro Asp Asp Lys Ser Lys Leu Pro Phe Thr Ile 
705                 710                 715                 720 


Ala Gln Leu Asp Lys Pro Lys Asn Thr Phe Glu Glu Trp Ile Asn Asn 
                725                 730                 735     


Ile Thr Lys Gly Lys Thr Lys Thr Asp Lys Glu Lys Pro Ile Asp Leu 
            740                 745                 750         


Pro Thr Asn Ile Phe Asp Lys Glu Ile Glu Glu Ile Leu Lys Asn Lys 
        755                 760                 765             


Leu Ser Glu Glu Lys Ile Ala Phe Thr Glu Asn Ala Asn Tyr Asn Gln 
    770                 775                 780                 


Leu Phe Lys Leu Trp Trp Thr Asp Cys Arg Lys Asp Asn Val Gln Lys 
785                 790                 795                 800 


Phe Tyr Asp Ala Glu Arg Glu Tyr Val Ile Tyr Asp Glu His Val Lys 
                805                 810                 815     


Phe Ile Pro Asn Thr Lys Pro Lys Phe Glu Asn Tyr Tyr Asn Glu Ser 
            820                 825                 830         


Phe Pro Ile Val Leu Thr Arg Leu Lys Arg Asp Arg Glu Glu Ala Arg 
        835                 840                 845             


Lys Leu Asn Arg Lys Leu Pro Pro Ile Glu Lys Ser Gln Val Glu Lys 
    850                 855                 860                 


Val Phe Lys Gln Ala Ile Gly Ser Thr Glu Lys Glu Ile Arg Leu Leu 
865                 870                 875                 880 


Gln Glu Glu Asp Arg Ile Met Leu Leu Met Phe Glu Gln Leu Leu Glu 
                885                 890                 895     


Thr Asp Asn Asn Leu Asn Leu Lys Leu Asn Asn Ala Glu Ser Leu Leu 
            900                 905                 910         


Asn Glu Gln Ile Thr Ile Lys Glu Lys Ile Ser Leu Lys Leu Ser Phe 
        915                 920                 925             


Asn Glu Gln Glu Asp Lys Lys Glu Ile Ile Lys Thr Ile Ile Asp Lys 
    930                 935                 940                 


Arg Lys Arg Lys Asp Phe Ser Ile Leu Arg Lys Phe Lys Tyr Asp Lys 
945                 950                 955                 960 


Arg Leu Pro Glu Leu Cys Glu Tyr Phe Glu Thr Asp Asp Ile Ser His 
                965                 970                 975     


Ser Asp Leu Lys Lys Glu Leu Asp Glu Tyr Asn Lys Ala Lys Glu Gln 
            980                 985                 990         


Ile Leu Ala Asn Ala Phe Met Leu  Glu Lys Thr Ile Ile  Glu Lys Asp 
        995                 1000                 1005             


Lys Asp  Gly Ile Lys Ala Leu  Phe Leu Asn Asp Asn  Gly Glu Lys 
    1010                 1015                 1020             


Lys Tyr  Gly Asn Val Gln His  Lys Pro Tyr Leu Thr  Trp Leu Lys 
    1025                 1030                 1035             


Asn Lys  Gly Leu Ile Asn Asp  Asn Glu Tyr Leu Phe  Ile Asn Met 
    1040                 1045                 1050             


Val Arg  Asn Thr Phe Ser His  Asn Gln Phe Pro Gln  Lys Arg Thr 
    1055                 1060                 1065             


Ile Gln  Ile Phe Ile Asp Lys  Asn Arg Gly Asn Pro  Ile Thr Phe 
    1070                 1075                 1080             


Ala Glu  Thr Ile Lys Asn Ala  Tyr Asn Lys Lys Ile  Glu Glu Ile 
    1085                 1090                 1095             


Ile Val  Lys Ile Lys 
    1100             


<210>  1455
<211>  1098
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1455

Met Glu Asn Asp Lys Lys Leu Glu Glu Ser Ala Cys Tyr Thr Leu Asn 
1               5                   10                  15      


Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val 
            20                  25                  30          


Tyr Ile Thr Val Asn His Ile Asn Lys Thr Leu Gly Glu Gly Glu Ile 
        35                  40                  45              


Asn Arg Asp Gly Tyr Glu Thr Thr Leu Glu Asn Thr Trp Asn Glu Ile 
    50                  55                  60                  


Lys Asp Ile Asn Lys Lys Ala Arg Leu Arg Glu Leu Ile Ile Lys His 
65                  70                  75                  80  


Phe Pro Phe Leu Glu Ala Ala Thr Tyr Gln Gln Arg Ser Thr Asp Ser 
                85                  90                  95      


Thr Lys Gln Lys Glu Glu Lys Gln Ala Glu Ala Gln Ser Leu Glu Ser 
            100                 105                 110         


Leu Lys His Cys Leu Phe Pro Phe Leu Lys Lys Leu Gln Lys Ser Arg 
        115                 120                 125             


Asp His Tyr Ser His Tyr Lys His Ser Lys Ser Leu Glu Arg Pro Lys 
    130                 135                 140                 


Phe Glu Glu Asp Leu Gln Lys Lys Met Tyr Asn Ile Phe Asp Val Ser 
145                 150                 155                 160 


Ile Arg Leu Val Lys Glu Asp Tyr Lys His Asn Thr Asp Ile Asn Leu 
                165                 170                 175     


Lys Glu Asp Phe Lys His Leu Asn Arg Thr Gly Lys Phe Lys Tyr Ser 
            180                 185                 190         


Phe Ala Asp Asn Lys Gly Asn Ile Thr Glu Ser Gly Leu Leu Phe Phe 
        195                 200                 205             


Ile Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Met Gln Lys Lys 
    210                 215                 220                 


Leu Lys Gly Phe Lys Asp Ser Arg Glu Lys Tyr Gln Lys Met Thr Asn 
225                 230                 235                 240 


Glu Val Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu Glu 
                245                 250                 255     


Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu Asn Glu Leu 
            260                 265                 270         


Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Arg Glu Lys Glu Arg 
        275                 280                 285             


Lys Glu Phe Lys Val Pro Ile Glu Ile Ala Asp Glu Asp Tyr Asp Ala 
    290                 295                 300                 


Glu Gln Glu Pro Phe Arg Asn Thr Leu Val Arg His Gln Asp Arg Phe 
305                 310                 315                 320 


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Tyr Asn Glu Ile Phe Thr Asn 
                325                 330                 335     


Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile Tyr Lys 
            340                 345                 350         


Lys Leu Ile Gly Gly Asn Lys Glu Asp Arg His Leu Thr His Lys Leu 
        355                 360                 365             


Tyr Gly Phe Glu Arg Ile Gln Glu Phe Ala Lys Gln Asn Arg Pro Asp 
    370                 375                 380                 


Glu Trp Lys Ala Leu Val Lys Asp Leu Asp Thr Phe Asn Lys Glu Glu 
385                 390                 395                 400 


Glu Lys Leu Tyr Ile Ser Glu Thr Thr Pro His Tyr His Leu Glu Asn 
                405                 410                 415     


Glu Lys Ile Gly Ile Val Phe Lys Asn His Asn Ile Trp Pro Ser Thr 
            420                 425                 430         


Gln Thr Glu Leu Thr Asn Asn Asn Arg Lys Lys Tyr Asn Leu Gly Val 
        435                 440                 445             


Ser Ile Lys Ala Glu Ala Phe Leu Ser Val His Glu Leu Leu Pro Met 
    450                 455                 460                 


Met Phe Tyr Tyr Leu Leu Leu Lys Thr Lys Asn Thr His Asn Gly Asn 
465                 470                 475                 480 


Glu Val Glu Ala Lys Lys Lys Gly Thr Lys Asn Lys Lys Gln Glu Lys 
                485                 490                 495     


His Lys Ile Glu Ala Ile Ile Glu Ser Lys Ile Lys Asp Ile Tyr Asn 
            500                 505                 510         


Leu Tyr Asp Ala Phe Ala Asn Gly Glu Ile Asn Ser Ile Glu Glu Leu 
        515                 520                 525             


Glu Glu His Cys Lys Gly Lys Asp Ile Glu Ile Gly His Leu Pro Lys 
    530                 535                 540                 


Gln Met Ile Ala Ile Leu Lys Asp Glu His Lys Asp Met Ala Lys Lys 
545                 550                 555                 560 


Ala Glu Thr Lys Gln Glu Lys Met Ile Leu Ala Thr Glu Asn Arg Leu 
                565                 570                 575     


Lys Thr Leu Asp Lys Lys Leu Lys Gly Lys Ile Arg Asn Gly Lys Arg 
            580                 585                 590         


Cys Asn Ser Ala Leu Lys Ser Gly Glu Ile Ala Ser Trp Leu Val Asn 
        595                 600                 605             


Asp Met Met Arg Phe Gln Pro Val Gln Arg Asp Glu Glu Gly Lys Pro 
    610                 615                 620                 


Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln Leu Leu Gln Arg 
625                 630                 635                 640 


Thr Leu Ala Phe Phe Gly Ser Glu His Glu Arg Leu Asp Pro Tyr Phe 
                645                 650                 655     


Lys Gln Met Asn Leu Ile Gly Asp Asn Asn Pro His Pro Phe Leu Asn 
            660                 665                 670         


Asp Thr Glu Trp Glu Lys Cys Asn Asn Ile Leu Ser Phe Tyr Arg Ser 
        675                 680                 685             


Tyr Leu Lys Ala Arg Lys Asn Phe Leu Glu Ser Leu Lys Pro Glu Asp 
    690                 695                 700                 


Trp Glu Lys Asn Gln Tyr Phe Leu Met Leu Lys Glu Pro Lys Thr Asn 
705                 710                 715                 720 


Arg Lys Thr Leu Val Gln Gly Trp Lys Asn Gly Phe Asn Leu Pro Arg 
                725                 730                 735     


Gly Ile Phe Thr Glu Pro Ile Arg Lys Trp Phe Met Glu His Trp Lys 
            740                 745                 750         


Ser Ile Lys Val Asp Asp Leu Lys Arg Val Gly Leu Val Ala Lys Val 
        755                 760                 765             


Ile Pro Leu Phe Phe Ser Glu Lys Tyr Lys Asp Ser Val Gln Pro Phe 
    770                 775                 780                 


Tyr Asn Tyr Pro Phe Asn Ile Gly Asn Ile Asn Lys Pro Glu Glu Lys 
785                 790                 795                 800 


Asp Phe Leu Asp Tyr Glu Lys Arg Lys Lys Leu Trp Asp Lys Lys Gln 
                805                 810                 815     


Ala Lys Phe Lys Gly Lys Thr Asp Lys Glu Lys Arg Glu Asp Pro Ser 
            820                 825                 830         


Tyr Pro Asp Phe Lys Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu 
        835                 840                 845             


Val Arg Asn Gln Asp Ile Val Thr Trp Met Leu Cys Met Glu Leu Phe 
    850                 855                 860                 


Glu Glu Gln Lys Val Asp Gly Leu Asn Thr Gly Gln Ile His Leu Lys 
865                 870                 875                 880 


Asp Ile Val Thr Asn Val Asp Glu Glu Gly Asn Asn Asn Ile Leu Asn 
                885                 890                 895     


Gln Ile Lys Pro Met Gln Leu Pro Ile Thr Val Tyr Asp Lys Glu Asn 
            900                 905                 910         


Ser Pro Lys Arg Lys Pro Leu His Thr Ile Tyr Ile Glu Glu Thr Gly 
        915                 920                 925             


Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys Asp Arg 
    930                 935                 940                 


Arg Leu Asn Gly Leu Phe Ser Phe Val Lys Thr Ser Ser Glu Ala Glu 
945                 950                 955                 960 


Ser Lys Ser Lys Pro Ile Ser Lys Leu Arg Val Glu Tyr Glu Leu Gly 
                965                 970                 975     


Ala Tyr Gln Lys Ala Arg Ile Asp Ile Ile Lys Asp Met Leu Ala Leu 
            980                 985                 990         


Glu Lys Thr Leu Ile Asp Asn Asp  Glu Asn Leu Pro Thr  Asn Lys Phe 
        995                 1000                 1005             


Ser Asp  Met Leu Lys Ser Trp  Leu Lys Gly Lys Gly  Glu Ala Asn 
    1010                 1015                 1020             


Lys Ala  Arg Leu Gln Asn Asp  Val Asp Leu Leu Val  Ala Val Arg 
    1025                 1030                 1035             


Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met Tyr Asn  Ser Glu Val 
    1040                 1045                 1050             


Phe Lys  Gly Met Lys Leu Leu  Ser Leu Ser Ser Asp  Ile Pro Glu 
    1055                 1060                 1065             


Lys Glu  Gly Leu Gly Ile Ala  Lys Gln Leu Lys Asp  Lys Ile Lys 
    1070                 1075                 1080             


Glu Thr  Ile Glu Arg Ile Ile  Glu Ile Glu Lys Glu  Ile Arg Asn 
    1085                 1090                 1095             


<210>  1456
<211>  1175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1456

Met Thr Glu Gln Asn Glu Arg Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Phe Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Ala His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Tyr Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Glu Lys Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Thr Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Phe Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Glu Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Gly Glu Ile Asp Thr Leu Asp 
    530                 535                 540                 


Arg Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Gly Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Leu Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Asp Leu Glu Ala Trp Ser His Ser Ala Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Ala Gly Ile Glu Asn Ala Ser Arg Glu Asn 
    850                 855                 860                 


Lys Lys Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Lys Ala 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Arg Gly Asp Lys Ile Asn Ile Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Ala Lys Glu His Pro Tyr His Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asp Ile Arg Thr 
945                 950                 955                 960 


Asp Val His Glu Gln Gly Ser Leu Asn Val Leu Asn Arg Val Lys Pro 
                965                 970                 975     


Met Arg Leu Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val 
            980                 985                 990         


His Lys Glu Gln Ala Pro Leu Ala  Thr Val Tyr Ile Glu  Glu Arg Asp 
        995                 1000                 1005             


Thr Lys  Leu Leu Lys Gln Gly  Asn Phe Lys Ser Phe  Val Lys Asp 
    1010                 1015                 1020             


Arg Arg  Leu Asn Gly Leu Phe  Ser Phe Val Asp Thr  Gly Gly Leu 
    1025                 1030                 1035             


Ala Met  Glu Gln Tyr Pro Ile  Ser Lys Leu Arg Val  Glu Tyr Glu 
    1040                 1045                 1050             


Leu Ala  Lys Tyr Gln Thr Ala  Arg Val Cys Ala Phe  Glu Gln Thr 
    1055                 1060                 1065             


Leu Glu  Leu Glu Glu Ser Leu  Leu Thr Arg Cys Pro  His Leu Pro 
    1070                 1075                 1080             


Asp Lys  Asn Phe Arg Glu Met  Leu Glu Ser Trp Ser  Asp Pro Leu 
    1085                 1090                 1095             


Leu Asp  Lys Trp Pro Asp Leu  His Gly Asn Val Arg  Leu Leu Ile 
    1100                 1105                 1110             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1115                 1120                 1125             


Glu Ala  Val Phe Ser Ser Ile  Arg Lys Tyr Asp Pro  Ser Phe Pro 
    1130                 1135                 1140             


Asp Ala  Ile Glu Glu Arg Met  Gly Leu Asn Ile Ala  His Arg Leu 
    1145                 1150                 1155             


Ser Glu  Glu Val Lys Gln Ala  Lys Glu Thr Val Glu  Arg Ile Ile 
    1160                 1165                 1170             


Gln Ala  
    1175 


<210>  1457
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1457

Met Asn Thr His Gln Glu Glu Leu Gln Ser Trp Ile Thr Arg Lys Arg 
1               5                   10                  15      


Leu Pro Asp Thr Glu Met Lys Lys Tyr Trp Ala Ala Tyr Met Asn Leu 
            20                  25                  30          


Ala Arg Leu Asn Phe Phe Lys Thr Leu Met Phe Ile Ser Asn Ser Ile 
        35                  40                  45              


Gly Asp Leu Lys Pro Ala Lys Asp Asn Asn Gly Lys Gly Asn Thr Glu 
    50                  55                  60                  


Val Asn Met His Asn Met Gly Ile Leu Thr Ala Leu Leu Gly Pro Glu 
65                  70                  75                  80  


Asp Glu Glu Lys Ala Arg Leu Leu Ile Phe Lys His Phe Pro Phe Leu 
                85                  90                  95      


Arg Thr Phe Cys Ile Glu Lys Glu Leu Ser Leu Ser Lys Gln Arg Thr 
            100                 105                 110         


Ile Leu Ile Asp Met Ala Cys Ile Ile Gly Arg Tyr Arg Asn Met Tyr 
        115                 120                 125             


Ser His Ser Ile Phe Ile Ser Asp Asp Asn Glu Lys Val Leu Glu Ser 
    130                 135                 140                 


Glu Lys Arg Cys Ser Glu Tyr Leu Gln Ser Ile Leu Thr Val Ser Thr 
145                 150                 155                 160 


Arg Ile Ile Lys Glu Arg Tyr Arg Ser Asn Lys Asn Asp Ala Gln Arg 
                165                 170                 175     


Gly Met Ile Asp Asp Lys Ser Leu Lys Phe Ile Ser Glu Asn Lys Val 
            180                 185                 190         


Lys Phe Val Tyr Asp Glu Asn Gly Glu Arg Ile Thr Ala Pro Asn Lys 
        195                 200                 205             


Lys Tyr Tyr Leu Ser Thr Ile Asp Lys Asp Asn Thr His Leu Ser Tyr 
    210                 215                 220                 


Phe Gly Lys Leu Met Leu Thr Cys Ile Leu Leu Glu Lys Lys Tyr Ala 
225                 230                 235                 240 


Thr Asp Phe Leu Thr Gln Cys His Phe Leu Asp Ala Phe Asn Asp Ser 
                245                 250                 255     


Glu Val Ala Pro Lys Leu Ser Glu Arg Arg Leu Met Leu Glu Val Met 
            260                 265                 270         


Thr Ala Leu Arg Ile Arg Leu Ala Glu Lys Lys Leu Ser Asn Glu Lys 
        275                 280                 285             


Ser Glu Val Gln Ile Ser Leu Asp Ile Leu Asn Glu Leu Lys Lys Cys 
    290                 295                 300                 


Pro Phe Glu Leu Tyr Glu Leu Leu Gly Ser Glu Asp Lys Arg Leu Phe 
305                 310                 315                 320 


Thr Ile Val Ala Asp Thr Gly Glu Thr Ile Leu Leu Arg Arg His Glu 
                325                 330                 335     


Asp Arg Phe Pro Gln Leu Ala Leu Ser Trp Ile Asp Ser Ser Lys Ala 
            340                 345                 350         


Phe Asp His Leu Arg Phe Gln Val Asn Ala Gly Lys Leu Arg Tyr Leu 
        355                 360                 365             


Phe Arg Asp Asn Lys His Cys Ile Asp Gly Gln Ala Arg Met Arg Ala 
    370                 375                 380                 


Leu Glu Glu Pro Leu Asn Gly Tyr Arg Arg Leu Met Glu Phe Glu Glu 
385                 390                 395                 400 


Glu Arg Ile Gln Lys Gln Ser Gly Glu Ile Arg Ser Leu Trp Pro Gly 
                405                 410                 415     


Leu Asp Ile Leu Asn Lys Asp Glu Thr Pro Arg Asn Asp Ala Ser Val 
            420                 425                 430         


Leu Pro Tyr Ile Ser Asp Tyr Arg Val Arg Tyr Leu Phe Asp Gly Asp 
        435                 440                 445             


Asn Ile Gly Ile Ser Ile Gly Asp Phe Thr Pro Ser Ile Thr Lys Thr 
    450                 455                 460                 


Asp Glu Thr Lys Tyr Arg Val Thr Gly Lys Thr Ala Asp Cys Cys Leu 
465                 470                 475                 480 


Ser Lys Tyr Glu Leu Pro Gly Leu Leu Phe Tyr His Leu Leu Thr Leu 
                485                 490                 495     


Arg His Gly Asp Asn Lys Arg Ser Ile Lys Asn Ala Glu Asp Ile Ile 
            500                 505                 510         


Ile Asp Ala Ile Lys Arg Tyr Lys Arg Leu Phe Ser Asp Val Lys Glu 
        515                 520                 525             


Gly Ile Leu Lys Pro Ile Lys Glu Glu Asn Ala Asn Gln Leu Gly Asn 
    530                 535                 540                 


Arg Ile Trp Asn Ser Tyr Gly Ile Asp Ile Lys Asp Ile Pro Asp Lys 
545                 550                 555                 560 


Ile Ile Asp Tyr Leu Leu Val Arg Glu Cys Asn Glu Asp Glu Lys Phe 
                565                 570                 575     


Thr Ala Trp Lys Asn Gly Leu Ile Ser Glu Met Leu Gln Ser Thr Lys 
            580                 585                 590         


Asn Arg Ile Lys Arg Phe Glu Lys Asp Ser Glu Ala Val Ile Ser Ser 
        595                 600                 605             


Asp Asn Lys Pro Gly Lys Lys Asn His Val Ser Leu Lys Pro Gly Ala 
    610                 615                 620                 


Tyr Ala Ser Phe Ile Ala Asn Asp Ile Val Phe Phe Gln Glu Cys Gly 
625                 630                 635                 640 


Ala Thr Glu Lys Met Thr Gly Leu Asn Phe Asn Val Met Gln Ser Arg 
                645                 650                 655     


Leu Ala Thr Phe Thr Lys Asp Gly Ser Thr Ser Phe Asn Ile Leu Leu 
            660                 665                 670         


Gln Thr Leu Lys Asn Ala His Leu Val Ser Thr Thr Tyr Gly Lys Gly 
        675                 680                 685             


Asp His Pro Phe Leu Tyr Arg Val Ile Lys Gln Gln Pro Ser Asp Ile 
    690                 695                 700                 


Val Gln Phe Tyr Lys Ile Tyr Leu Asn Glu Lys Val Leu Tyr Leu Gln 
705                 710                 715                 720 


Ser Asp Ile Pro Asp Asn Ala Ile Phe Leu His Gly Glu Arg Lys Arg 
                725                 730                 735     


Trp Glu Asn Arg Asn Glu Gln Tyr Tyr Arg Asp Leu Ala Glu Arg Tyr 
            740                 745                 750         


Leu Gln Arg Pro Ile Gln Leu Pro Arg Gln Leu Phe Glu Ser His Ile 
        755                 760                 765             


Arg Gln Leu Leu Leu Ser Asp Cys Ile Lys Gly Glu Arg Gly Asn Asp 
    770                 775                 780                 


Leu Lys Glu Ala Ile Asn Ser Ala Ala Ser Gln Gly Arg Cys Asn Thr 
785                 790                 795                 800 


Thr Tyr Met Ile Met Glu Tyr Phe Ala Asp Tyr Leu Cys Asp Gly Thr 
                805                 810                 815     


Gln Phe Phe Tyr Gly Leu Phe Asp Gly Asp Leu Ser His Glu Tyr Asn 
            820                 825                 830         


Tyr Arg Phe Tyr Ser Leu Ile Ser Asn Asn Ile Glu Asn Ser Lys Lys 
        835                 840                 845             


Leu Val Leu Thr Leu Lys Lys Gly Asn Asn Ser Lys Glu Ser Pro Phe 
    850                 855                 860                 


Ile Ser Ala Leu Glu Arg Gly Ile His Trp Ser Lys Met Asn Pro Leu 
865                 870                 875                 880 


Met Lys Lys Gly Leu Lys Asn Asp Ser Ser Glu Gly Asp Phe Val His 
                885                 890                 895     


Ala Ala Lys Arg Ala Tyr Lys Glu Met Thr Glu Thr Glu Arg Met Phe 
            900                 905                 910         


Arg Arg Tyr Ala Val Gln Asp Glu Val Leu Phe Leu Ala Ala Lys Ile 
        915                 920                 925             


Thr Ile Arg Arg Ala Leu Gly Leu Ser Glu Gln Tyr Asn Cys Leu Leu 
    930                 935                 940                 


Gly Asp Ile Lys Pro Gln Gly Gly Ser Leu Leu Glu Gln Thr Ile Pro 
945                 950                 955                 960 


Ser Ile Thr Thr Lys His Thr Ile Asn Thr Gly Asn Lys Lys Gln Lys 
                965                 970                 975     


Pro Lys Gln Val Gln Ile Leu Gln Lys Asn Val Lys Leu Lys Asp Phe 
            980                 985                 990         


Gly Lys Val Phe Lys Leu Leu Asn  Asp Arg Arg Ile Phe  Asp Leu Leu 
        995                 1000                 1005             


Phe Asn  Lys Gly Asn Glu Ala  Val Ser Met Thr Asp  Leu Cys Glu 
    1010                 1015                 1020             


Glu Leu  Glu Arg Tyr Asp Arg  His Arg Val Asp Val  Phe Asp Ser 
    1025                 1030                 1035             


Val Leu  Lys Tyr Glu Ser Lys  Ile Thr Lys Gly Tyr  Thr Asn Lys 
    1040                 1045                 1050             


Glu Leu  Met Asn Glu Ser Gly  Gln Ile Asp Phe Lys  Ala Ile Gln 
    1055                 1060                 1065             


Ala Phe  Asp Lys Gln Asn Thr  Thr Ala Asp Lys Glu  Asp Leu Arg 
    1070                 1075                 1080             


Leu Ile  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Gln Tyr Asn 
    1085                 1090                 1095             


Asn Glu  Pro Ile Leu Phe Asp  Lys Asp Ile Pro Glu  Ile Ala Asp 
    1100                 1105                 1110             


Glu Ile  Ser Ile Ile Ala Lys  Asp Ile Glu Glu Asn  Thr Lys 
    1115                 1120                 1125         


<210>  1458
<211>  1113
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1458

Met Pro Leu Arg Phe Lys Asn Ala Glu Glu Arg Lys Pro Val Leu Gly 
1               5                   10                  15      


Ala Tyr Ala Ala Met Ala Arg Asn Asn Ala Tyr Ile Ile Leu Ser Asp 
            20                  25                  30          


Ile Met Glu Arg Leu His Ile Glu Gln Pro Pro Leu Pro Asp Pro Ala 
        35                  40                  45              


His Pro Gly Gln Cys Leu Asp Lys Glu Ser His Leu Asp Lys Leu Ser 
    50                  55                  60                  


Leu Phe Pro Gln Asn Asn Asp Leu Met Pro Glu Thr Met Asp Lys Ala 
65                  70                  75                  80  


Met Lys Leu Leu Cys Ser His Phe Pro Phe Leu Gln Thr Glu Gly Asp 
                85                  90                  95      


Leu Arg Ile Met Asn Ala Pro Asp Gly Arg Glu Gln Glu Lys Ile Pro 
            100                 105                 110         


Ile Thr Tyr Glu Glu Lys Cys Arg Thr Leu Leu Asp Ala Leu Ala Val 
        115                 120                 125             


Leu Thr Tyr Leu Arg Asp Ala Asn Leu His Tyr Leu Phe Asn Asp Arg 
    130                 135                 140                 


Arg Ala Glu His Leu Glu Tyr Arg Leu Pro Glu Ser Lys Thr Cys His 
145                 150                 155                 160 


Leu Leu Arg Leu Val Leu Lys Ala Ala Pro Arg Lys Ile Ser Glu Arg 
                165                 170                 175     


Tyr Lys Gly Thr Gly Leu Met Pro Asp Gly Ala Leu Asp Phe Phe Ile 
            180                 185                 190         


Lys Lys Gln Tyr Val Arg Glu Gly Arg Ser Phe Lys Phe Asn Met Asn 
        195                 200                 205             


Trp Leu Phe Ser Pro Gln Arg Glu Pro Glu Lys Arg Glu Met Asp Val 
    210                 215                 220                 


Tyr Arg Lys Val Glu Leu Ala Gly Gly Val Glu Arg Val Leu Val Ala 
225                 230                 235                 240 


Asn Pro Asp Gly Thr Pro Ala Arg Phe Asn Arg Leu Ser Leu Phe Gly 
                245                 250                 255     


Glu Val Leu Leu Ile Ser Leu Phe Thr Glu Lys Arg Tyr Ile Pro Asp 
            260                 265                 270         


Phe Leu Lys Ala Cys Gly Leu Leu Thr Asp Asn Gly Phe Thr Glu Thr 
        275                 280                 285             


Thr Gln Asp Gly Thr Leu Ser Gln Gln Arg Leu Ile Arg Glu Ile Val 
    290                 295                 300                 


Ala Ala Tyr Ser Ile Arg Leu Pro Lys Arg Arg Leu Asp Ile Thr Met 
305                 310                 315                 320 


Asp Ala Asp Gln Val Met Leu Asp Ile Phe Asn Glu Leu Ala Lys Cys 
                325                 330                 335     


Pro Asp Glu Leu Tyr Ser Val Leu Pro Glu Ala Lys Lys Arg Glu Leu 
            340                 345                 350         


Glu Ala Val Asn Ile Asp Glu Glu Thr Val Ile Lys Lys Arg His Ser 
        355                 360                 365             


Asp Arg Phe Val Pro Leu Leu Leu Arg Phe Ile Asp Ala Asn Glu Leu 
    370                 375                 380                 


Phe Pro Ser Ile Arg Phe Gln Val Asn Ser Gly Tyr Leu Arg Phe Leu 
385                 390                 395                 400 


His His Glu Lys Ala Ala Tyr Met Asp Gly Val Glu Arg Pro Arg Ile 
                405                 410                 415     


Leu Gln Asp Ala Val Asn Gly Phe Gly Arg Ile Gln Glu Val Glu Arg 
            420                 425                 430         


Lys Arg Ser Ala Ser Asp Thr Tyr Leu Gly Phe Pro Leu Tyr Ala Pro 
        435                 440                 445             


Ser Pro Asp Asp Asp Val Thr Met Pro Leu Pro Cys Ile Thr Glu Ser 
    450                 455                 460                 


Ala Ser Arg Tyr Ile Val Asn Gly Glu Cys Ile Gly Leu Ser Ile Ser 
465                 470                 475                 480 


Gly Asp Arg Thr Pro Val Ile Ile Gln Asp Gly Gly Lys Tyr Arg Val 
                485                 490                 495     


Arg Ser Pro Gln Pro Asp Cys Trp Ile Ser Arg Tyr Glu Leu Gln Ala 
            500                 505                 510         


Met Gly Phe Tyr Leu Tyr Leu Ser Gln Lys Tyr Asp Leu Pro Val Ser 
        515                 520                 525             


Ala Glu Lys Ile Ile Val Asp Lys Val Asn Glu Tyr Arg Ser Phe Phe 
    530                 535                 540                 


Gln Gly Val Ala Asn Gly Thr Ile Thr Ser Leu Lys Gly Val Thr Leu 
545                 550                 555                 560 


Ala Glu Lys Asp Ile Pro Gly Lys Leu Leu Asn Tyr Leu Asn Gly Lys 
                565                 570                 575     


Thr Asp Ser Ser Asp Phe Asn Arg Tyr Lys Lys Asn Leu Ile Gln Ser 
            580                 585                 590         


Leu Leu Glu Lys Thr Val Asn Arg Leu Lys Arg Phe Leu Glu Asp Met 
        595                 600                 605             


Ala Met Val Gly Ser Lys Glu Asn Arg Ile Gly Lys Arg Ser Phe Val 
    610                 615                 620                 


Arg Val Leu Pro Gly Lys Leu Ala Ser Tyr Leu Ala Asp Asp Ile Val 
625                 630                 635                 640 


Phe Phe Gln Ser Tyr Pro Ala Gly His Pro Glu Lys Arg Leu Thr Gly 
                645                 650                 655     


Gln Gln Phe Ser Ile Leu Gln Gly Leu Leu Ala Thr Phe Pro Pro Asp 
            660                 665                 670         


Ile Glu Asp Ser Cys Arg Arg Ala Gly Leu Leu Ser Gly Glu Thr Ala 
        675                 680                 685             


His Pro Phe Leu Lys Ala Val Phe Asp Ser Ile Pro Ala Lys Asp Arg 
    690                 695                 700                 


Asn Thr Leu Val Phe Tyr Glu Ile Tyr Leu Lys Arg Lys Ile Ala Phe 
705                 710                 715                 720 


Leu Lys Gly Pro Ile Pro Asp Ser Ala Pro Phe Leu His Pro Gly Lys 
                725                 730                 735     


Val Lys Trp Gln Lys Lys Asp Ala Ala Tyr Tyr Lys Ala Leu Ala Gln 
            740                 745                 750         


Arg Tyr Leu Asp Gly Gly Lys Asp Gly Ser Asn Thr Gly Ile Leu Leu 
        755                 760                 765             


Pro Arg Gly Leu Phe Asp Gln Ala Ile Thr Asp Val Leu Thr Lys Arg 
    770                 775                 780                 


Cys Pro Gly Trp Ser Arg Ala Ile Gln Asn Thr Asp His Ala Asn Thr 
785                 790                 795                 800 


Ala Phe Lys Ile Ile Thr Tyr Leu Leu Asp Gly Gln Ala Asp Asp Tyr 
                805                 810                 815     


Gln Trp Phe Tyr Tyr Glu Glu Asp Arg Leu Gln Glu Tyr Arg Phe Ser 
            820                 825                 830         


Gln Leu Ile Ile Ser Gln Asn Ala Val Arg Asn Gly Trp Lys Asp Leu 
        835                 840                 845             


Lys Ala Ile Leu Gln Glu Glu Gly Val Lys Leu Lys Gly Asn Tyr Tyr 
    850                 855                 860                 


Lys Glu Leu Glu Gly Arg Ile Ser Ala Leu Arg Arg Ile Pro Pro Glu 
865                 870                 875                 880 


Arg Leu Ala Arg Asn Thr Met Lys Arg Glu Glu Leu Arg Gln Ala Leu 
                885                 890                 895     


Arg Ser Ser Tyr Asp Arg Met Cys Asp Asn Glu Lys Ser Ile Arg Arg 
            900                 905                 910         


Ile Ile Val Gln Asp Ile Val Leu Phe Leu Leu Ala Arg Trp Arg Leu 
        915                 920                 925             


Asp Pro Arg Glu Lys Leu Asn Met Ser Met Ile Gly Gln Asp Glu Ser 
    930                 935                 940                 


Lys Leu Met Asn Gln Val Val Thr Val Asp Thr Leu Tyr Lys Gly Gln 
945                 950                 955                 960 


Tyr Arg Ile Arg Gln Asn Asp Val Arg Ile Lys Asp Gln Gly Val Leu 
                965                 970                 975     


Phe Lys Thr Leu Asn Asp Lys Arg Ile Asp Ser Leu Leu Asp Gln Leu 
            980                 985                 990         


Thr Val Gly Glu Gly Glu Val Ile  Asp Leu Glu Asp Leu  Ile Ala Glu 
        995                 1000                 1005             


Leu Thr  Arg Tyr Asp Asp Arg  Arg Ile Pro Val Val  Ala Lys Ile 
    1010                 1015                 1020             


Met Glu  Tyr Glu Lys Arg Val  Leu Lys Asn His Pro  Glu Leu Arg 
    1025                 1030                 1035             


Asp Arg  Arg Gly Arg Met Asp  Phe Lys Ser Val Gln  Arg Ala Asp 
    1040                 1045                 1050             


Glu Ala  Ser Ser Pro Gln Lys  Lys Val Val Leu Arg  Thr Val Arg 
    1055                 1060                 1065             


Asn Ala  Phe Ser His Asn Ala  Tyr Pro Asp Arg Val  Val Lys Ala 
    1070                 1075                 1080             


Glu Gly  Glu Glu Gly Ile Glu  Ile Tyr Asn Pro Ile  Ile Pro Gly 
    1085                 1090                 1095             


Met Ala  Asp Gly Ile Ser Gly  Thr Thr Asn Lys Leu  Val Asp Glu 
    1100                 1105                 1110             


<210>  1459
<211>  1175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1459

Met Thr Glu Gln Asn Glu Arg Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Thr His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Asn Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro Arg Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Tyr Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Glu Lys Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Ala Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Asp Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Phe Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Asp Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Gly Glu Ile Asp Thr Arg Asp 
    530                 535                 540                 


Glu Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Ser Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Leu Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asn Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Glu Arg Ile Lys Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Asp Leu Glu Ala Trp Ser His Gly Ala Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Val Gly Ile Glu Tyr Ala Ser Pro Gly Asn 
    850                 855                 860                 


Lys Lys Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Glu Thr 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Lys Ala Asp Lys Ile Asn Ile Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Ala Lys Glu His Pro Tyr Leu Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asp Ile Arg Thr 
945                 950                 955                 960 


Asp Val His Glu Gln Gly Ser Leu Asn Val Leu Asn Arg Val Lys Pro 
                965                 970                 975     


Met Arg Leu Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val 
            980                 985                 990         


His Lys Glu Gln Ala Pro Leu Ala  Thr Val Tyr Ile Glu  Glu Arg Asp 
        995                 1000                 1005             


Thr Lys  Leu Leu Lys Gln Gly  Asn Phe Lys Ser Phe  Val Lys Asp 
    1010                 1015                 1020             


Arg Arg  Leu Asn Gly Leu Phe  Ser Phe Val Asp Thr  Gly Ala Leu 
    1025                 1030                 1035             


Ala Met  Glu Gln Tyr Pro Ile  Ser Lys Leu Arg Val  Glu Tyr Glu 
    1040                 1045                 1050             


Leu Ala  Lys Tyr Gln Thr Ala  Arg Val Cys Ala Phe  Glu Gln Thr 
    1055                 1060                 1065             


Leu Gly  Leu Glu Glu Ser Leu  Leu Thr Arg Tyr Pro  His Leu Pro 
    1070                 1075                 1080             


Asp Lys  Asn Phe Arg Lys Met  Leu Glu Ser Trp Ser  Asp Pro Leu 
    1085                 1090                 1095             


Leu Asp  Lys Trp Pro Asp Leu  His Gly Asn Val Arg  Leu Leu Ile 
    1100                 1105                 1110             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1115                 1120                 1125             


Glu Thr  Leu Phe Ser Ser Ile  Arg Lys Tyr Asp Pro  Ser Ser Pro 
    1130                 1135                 1140             


Asp Ala  Ile Glu Glu Arg Met  Gly Leu Asn Ile Ala  His Arg Leu 
    1145                 1150                 1155             


Ser Glu  Glu Val Lys Gln Ala  Lys Glu Met Val Glu  Arg Ile Ile 
    1160                 1165                 1170             


Gln Ala  
    1175 


<210>  1460
<211>  1135
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1460

Met Asn Thr Val Pro Ala Ser Glu Asn Lys Gly Gln Ser Arg Thr Val 
1               5                   10                  15      


Glu Asp Asp Pro Gln Tyr Phe Gly Leu Tyr Leu Asn Leu Ala Arg Glu 
            20                  25                  30          


Asn Leu Ile Glu Val Glu Ser His Val Arg Ile Lys Phe Gly Lys Lys 
        35                  40                  45              


Lys Leu Asn Glu Glu Ser Leu Lys Gln Ser Leu Leu Cys Asp His Leu 
    50                  55                  60                  


Leu Ser Val Asp Arg Trp Thr Lys Val Tyr Gly His Ser Arg Arg Tyr 
65                  70                  75                  80  


Leu Pro Phe Leu His Tyr Phe Asp Pro Asp Ser Gln Ile Glu Lys Asp 
                85                  90                  95      


His Asp Ser Lys Thr Gly Val Asp Pro Asp Ser Ala Gln Arg Leu Ile 
            100                 105                 110         


Arg Glu Leu Tyr Ser Leu Leu Asp Phe Leu Arg Asn Asp Phe Ser His 
        115                 120                 125             


Asn Arg Leu Asp Gly Thr Thr Phe Glu His Leu Glu Val Ser Pro Asp 
    130                 135                 140                 


Ile Ser Ser Phe Ile Thr Gly Thr Tyr Ser Leu Ala Cys Gly Arg Ala 
145                 150                 155                 160 


Gln Ser Arg Phe Ala Asp Phe Phe Lys Pro Asp Asp Phe Val Leu Ala 
                165                 170                 175     


Lys Asn Arg Lys Glu Gln Leu Ile Ser Val Ala Asp Gly Lys Glu Cys 
            180                 185                 190         


Leu Thr Val Ser Gly Leu Ala Phe Phe Ile Cys Leu Phe Leu Asp Arg 
        195                 200                 205             


Glu Gln Ala Ser Gly Met Leu Ser Arg Ile Arg Gly Phe Lys Arg Thr 
    210                 215                 220                 


Asp Glu Asn Trp Ala Arg Ala Val His Glu Thr Phe Cys Asp Leu Cys 
225                 230                 235                 240 


Ile Arg His Pro His Asp Arg Leu Glu Ser Ser Asn Thr Lys Glu Ala 
                245                 250                 255     


Leu Leu Leu Asp Met Leu Asn Glu Leu Asn Arg Cys Pro Arg Ile Leu 
            260                 265                 270         


Tyr Asp Met Leu Pro Glu Glu Glu Arg Ala Gln Phe Leu Pro Ala Leu 
        275                 280                 285             


Asp Glu Asn Ser Met Asn Asn Leu Ser Glu Asn Ser Leu Asn Glu Glu 
    290                 295                 300                 


Ser Arg Leu Leu Trp Asp Gly Ser Ser Asp Trp Ala Glu Ala Leu Thr 
305                 310                 315                 320 


Lys Arg Ile Arg His Gln Asp Arg Phe Pro Tyr Leu Met Leu Arg Phe 
                325                 330                 335     


Ile Glu Glu Met Asp Leu Leu Lys Gly Ile Arg Phe Arg Val Asp Leu 
            340                 345                 350         


Gly Glu Ile Glu Leu Asp Ser Tyr Ser Lys Lys Val Gly Arg Asn Gly 
        355                 360                 365             


Glu Tyr Asp Arg Thr Ile Thr Asp His Ala Leu Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Asp Phe Gln Asn Glu Glu Glu Val Ser Arg Met Ile Ser Gly Glu 
385                 390                 395                 400 


Ala Ser Tyr Pro Val Arg Phe Ser Leu Phe Ala Pro Arg Tyr Ala Ile 
                405                 410                 415     


Tyr Asp Asn Lys Ile Gly Tyr Cys His Thr Ser Asp Pro Val Tyr Pro 
            420                 425                 430         


Lys Ser Lys Thr Gly Glu Lys Arg Ala Leu Ser Asn Pro Arg Ser Met 
        435                 440                 445             


Gly Phe Ile Ser Val His Asp Leu Arg Lys Leu Leu Leu Met Glu Leu 
    450                 455                 460                 


Leu Cys Glu Gly Ser Phe Ser Arg Met Gln Ser Asp Phe Leu Arg Lys 
465                 470                 475                 480 


Ala Asn Arg Ile Leu Asp Glu Thr Ala Glu Gly Lys Leu Gln Phe Ser 
                485                 490                 495     


Ala Leu Phe Pro Glu Met Arg His Arg Phe Ile Pro Pro Gln Asn Pro 
            500                 505                 510         


Lys Ser Lys Asp Arg Arg Glu Lys Ala Glu Thr Thr Leu Glu Lys Tyr 
        515                 520                 525             


Lys Gln Glu Ile Lys Gly Arg Lys Asp Lys Leu Asn Ser Gln Leu Leu 
    530                 535                 540                 


Ser Ala Phe Asp Met Asp Gln Arg Gln Leu Pro Ser Arg Leu Leu Asp 
545                 550                 555                 560 


Glu Trp Met Asn Ile Arg Pro Ala Ser His Ser Val Lys Leu Arg Thr 
                565                 570                 575     


Tyr Val Lys Gln Leu Asn Glu Asp Cys Arg Leu Arg Leu Gln Lys Phe 
            580                 585                 590         


Arg Lys Asp Gly Asp Gly Lys Ala Arg Ala Ile Pro Leu Val Gly Glu 
        595                 600                 605             


Met Ala Thr Phe Leu Ser Gln Asp Ile Val Arg Met Ile Ile Ser Glu 
    610                 615                 620                 


Glu Thr Lys Lys Leu Ile Thr Ser Ala Tyr Tyr Asn Glu Met Gln Arg 
625                 630                 635                 640 


Ser Leu Ala Gln Tyr Ala Gly Glu Glu Asn Arg His Gln Phe Arg Ala 
                645                 650                 655     


Ile Val Ala Glu Leu Arg Leu Leu Asp Pro Ser Ser Gly His Pro Phe 
            660                 665                 670         


Leu Ser Ala Thr Met Glu Thr Ala His Arg Tyr Thr Glu Asp Phe Tyr 
        675                 680                 685             


Lys Cys Tyr Leu Glu Lys Lys Arg Glu Trp Leu Ala Lys Thr Phe Tyr 
    690                 695                 700                 


Arg Pro Glu Gln Asp Glu Asn Thr Lys Arg Arg Ile Ser Val Phe Phe 
705                 710                 715                 720 


Val Pro Asp Gly Glu Ala Arg Lys Leu Leu Pro Leu Leu Ile Arg Arg 
                725                 730                 735     


Arg Met Lys Glu Gln Asn Asp Leu Gln Asp Trp Ile Arg Asn Lys Gln 
            740                 745                 750         


Ala His Pro Ile Asp Leu Pro Ser His Leu Phe Asp Ser Lys Ile Met 
        755                 760                 765             


Glu Leu Leu Lys Val Lys Asp Gly Lys Lys Lys Trp Asn Glu Ala Phe 
    770                 775                 780                 


Lys Asp Trp Trp Ser Thr Lys Tyr Pro Asp Gly Met Gln Pro Phe Tyr 
785                 790                 795                 800 


Gly Leu Arg Arg Glu Leu Asn Ile His Gly Lys Ser Val Ser Tyr Ile 
                805                 810                 815     


Pro Ser Asp Gly Lys Lys Phe Ala Tyr Cys Tyr Thr His Leu Met Glu 
            820                 825                 830         


Lys Thr Val Gln Asp Lys Lys Arg Glu Leu Arg Thr Ala Gly Lys Pro 
        835                 840                 845             


Val Pro Pro Asp Leu Ala Ala Asp Ile Lys Arg Ser Phe His Arg Ala 
    850                 855                 860                 


Val Asn Glu Arg Glu Phe Met Leu Arg Leu Val Gln Glu Asp Asp Arg 
865                 870                 875                 880 


Leu Met Leu Met Ala Ile Asn Lys Met Met Thr Asp Arg Glu Glu Asp 
                885                 890                 895     


Ile Leu Pro Gly Leu Lys Asn Ile Asp Ser Ile Leu Asp Glu Glu Asn 
            900                 905                 910         


Gln Phe Ser Leu Ala Val His Ala Lys Val Leu Glu Lys Glu Gly Glu 
        915                 920                 925             


Gly Gly Asp Asn Ser Leu Ser Leu Val Pro Ala Thr Ile Glu Ile Lys 
    930                 935                 940                 


Ser Lys Arg Lys Asp Trp Ser Lys Tyr Ile Arg Tyr Arg Tyr Asp Arg 
945                 950                 955                 960 


Arg Val Pro Gly Leu Met Ser His Phe Pro Glu His Lys Ala Thr Leu 
                965                 970                 975     


Asp Glu Val Lys Thr Leu Leu Gly Glu Tyr Asp Arg Cys Arg Ile Lys 
            980                 985                 990         


Ile Phe Asp Trp Ala Phe Ala Leu  Glu Gly Ala Ile Met  Ser Asp Arg 
        995                 1000                 1005             


Asp Leu  Lys Pro Tyr Leu His  Glu Ser Ser Ser Arg  Glu Gly Lys 
    1010                 1015                 1020             


Ser Gly  Glu His Ser Thr Leu  Val Lys Met Leu Val  Glu Lys Lys 
    1025                 1030                 1035             


Gly Cys  Leu Thr Pro Asp Glu  Ser Gln Tyr Leu Ile  Leu Ile Arg 
    1040                 1045                 1050             


Asn Lys  Ala Ala His Asn Gln  Phe Pro Cys Ala Ala  Glu Met Pro 
    1055                 1060                 1065             


Leu Ile  Tyr Arg Asp Val Ser  Ala Lys Val Gly Ser  Ile Glu Gly 
    1070                 1075                 1080             


Ser Ser  Ala Lys Asp Leu Pro  Glu Gly Ser Ser Leu  Val Asp Ser 
    1085                 1090                 1095             


Leu Trp  Lys Lys Tyr Glu Met  Ile Ile Arg Lys Ile  Leu Pro Ile 
    1100                 1105                 1110             


Leu Asp  Pro Glu Asn Arg Phe  Phe Gly Lys Leu Leu  Asn Asn Met 
    1115                 1120                 1125             


Ser Gln  Pro Ile Asn Asp Leu  
    1130                 1135 


<210>  1461
<211>  1146
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1461

Met Glu Ser Ile Ile Gly Leu Gly Leu Ser Phe Asn Pro Tyr Lys Thr 
1               5                   10                  15      


Ala Asp Lys His Tyr Phe Gly Ser Phe Leu Asn Leu Ala Asp Asn Asn 
            20                  25                  30          


Leu Lys Ala Val Phe Ala Glu Phe Lys Glu Arg Ile Ser Asp Lys Ser 
        35                  40                  45              


Lys Asp Glu Asp Ile Ser Asn Leu Ile Glu Lys His Phe Ile Asp Asn 
    50                  55                  60                  


Met Ser Ile Val Asp Tyr Glu Lys Asn Ile Ser Ile Leu Asn Gly Tyr 
65                  70                  75                  80  


Leu Pro Ile Ile Asp Phe Leu Asp Asp Glu Leu Glu Asn Asn Leu Asn 
                85                  90                  95      


Thr Arg Val Lys Asn Phe Lys Lys Ser Phe Ile Ile Leu Ala Glu Ala 
            100                 105                 110         


Leu Glu Thr Leu Arg Asn Tyr Tyr Thr His Phe Tyr His Asp Pro Ile 
        115                 120                 125             


Thr Phe Gly Asp Asn Lys Glu Pro Leu Leu Glu Leu Leu Asp Glu Val 
    130                 135                 140                 


Leu Leu Lys Thr Ile Leu Asp Val Lys Lys Lys Tyr Leu Lys Thr Asp 
145                 150                 155                 160 


Lys Thr Lys Glu Ile Leu Lys Asp Ser Leu Arg Glu Glu Met Asp Leu 
                165                 170                 175     


Leu Val Ile Arg Lys Thr Asp Glu Leu Arg Glu Lys Lys Lys Thr Asn 
            180                 185                 190         


Pro Lys Phe Lys Phe Ser Thr Asp Pro Thr Gln Ile Arg Asn Ser Ile 
        195                 200                 205             


Phe Asn Asp Ala Phe Gln Gly Leu Leu Tyr Glu Asp Lys Glu Asn Asn 
    210                 215                 220                 


Gly Lys Thr Gln Val Ser Tyr Arg Ala Lys Thr Lys Leu Asn Pro Lys 
225                 230                 235                 240 


Asp Ile His Lys Gln Glu Glu Arg Asp Phe Glu Ile Pro Leu Ser Thr 
                245                 250                 255     


Ser Gly Ile Val Phe Leu Met Ser Leu Phe Leu Ser Lys Lys Glu Ile 
            260                 265                 270         


Glu Asp Phe Lys Ser Asn Ile Lys Gly Phe Lys Gly Lys Val Val Lys 
        275                 280                 285             


Asp Glu Asn His Asn Ser Leu Lys Tyr Met Ala Thr His Arg Val Tyr 
    290                 295                 300                 


Ser Ile Leu Ala Phe Lys Gly Leu Lys Tyr Arg Ile Lys Thr Asp Thr 
305                 310                 315                 320 


Phe Ser Lys Val Thr Leu Met Met Gln Met Ile Asp Glu Leu Ser Lys 
                325                 330                 335     


Val Pro Asp Cys Val Tyr Gln Asn Leu Ser Glu Thr Lys Gln Lys Asp 
            340                 345                 350         


Phe Ile Glu Asp Trp Asn Glu Tyr Leu Lys Asp Asn Glu Glu Asn Thr 
        355                 360                 365             


Glu Asn Leu Glu Asn Ser Arg Val Val His Pro Leu Ile Arg Lys Arg 
    370                 375                 380                 


Tyr Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe 
385                 390                 395                 400 


Ala Asn Phe Lys Thr Leu Lys Phe Gln Val Phe Met Gly Tyr Tyr Ile 
                405                 410                 415     


His Asp Gln Arg Thr Lys Thr Ile Gly Thr Thr Asn Ile Thr Thr Glu 
            420                 425                 430         


Arg Thr Val Lys Glu Lys Ile Asn Val Phe Gly Lys Leu Ser Lys Met 
        435                 440                 445             


Asp Asn Leu Lys Lys His Phe Phe Ser Gln Leu Ser Asp Glu Glu Asn 
    450                 455                 460                 


Thr Asp Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Phe Leu Thr Gln 
465                 470                 475                 480 


Ala Asp Asn Ser Pro Ala Asn Asn Ile Pro Ile Tyr Leu Glu Leu Lys 
                485                 490                 495     


Asn Gln Gln Ile Ile Lys Glu Lys Asp Asp Ile Lys Ala Glu Val Asn 
            500                 505                 510         


Asn Ser Gln Asn Arg Asn Pro Asn Lys Pro Ser Lys Arg Asp Leu Leu 
        515                 520                 525             


Asn Lys Ile Ser Asn Thr Asn Glu Asp Phe Tyr Gln Gly Asp Pro Thr 
    530                 535                 540                 


Ala Ile Leu Ser Leu Asn Glu Ile Pro Ala Leu Leu His Leu Phe Leu 
545                 550                 555                 560 


Val Gln Pro Asp Asn Lys Thr Gly Gln Gln Ile Glu Asn Ile Ile Arg 
                565                 570                 575     


Ile Lys Ile Glu Lys Gln Phe Asn Ser Ile Lys Asn Pro Ser Lys Asp 
            580                 585                 590         


Asp Lys Gly Val Pro Lys Ser Leu Phe Ala Asp Thr Asn Val Arg Val 
        595                 600                 605             


Asn Ala Ile Lys Leu Lys Lys Asp Leu Gly Glu Glu Leu Asp Met Leu 
    610                 615                 620                 


Asn Lys Lys Gln Ile Val Phe Lys Glu Asn Gln Lys Ala Ser Ser Asn 
625                 630                 635                 640 


Tyr Asp Glu Leu Leu Lys Lys His Gln Phe Thr Pro Lys Asn Lys Arg 
                645                 650                 655     


Pro Ala Leu Arg Lys Tyr Val Phe Tyr Asn Ser Glu Lys Gly Glu Glu 
            660                 665                 670         


Ala Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Lys Gly Phe 
        675                 680                 685             


Lys Thr Lys Trp Lys Gly Tyr Gln His Ser Glu Leu Gln Arg Lys Leu 
    690                 695                 700                 


Ala Phe Tyr Asp Arg His Thr Lys Gln Asp Ile Lys Glu Leu Leu Ser 
705                 710                 715                 720 


Gly Cys Glu Phe Asp His Phe Leu Leu Asp Ile Asn Ala Cys Phe Lys 
                725                 730                 735     


Glu Asp Asp Phe Glu Asp Phe Phe Ser Lys Tyr Leu Lys Asn Arg Ile 
            740                 745                 750         


Glu Thr Leu Asn Ile Ile Leu Lys Gln Leu His Asp Phe Lys Asn Glu 
        755                 760                 765             


Pro Thr Pro Leu Lys Gly Val Phe Lys Asn Cys Leu Lys Phe Leu Lys 
    770                 775                 780                 


Gln Lys Asn Tyr Val Thr Glu Asn Pro Glu Ile Ile Lys Lys Arg Ile 
785                 790                 795                 800 


Leu Ala Lys Pro Ala Phe Leu Pro Arg Gly Ile Phe Asp Glu Arg Pro 
                805                 810                 815     


Thr Met Lys Lys Gly Lys Asn Pro Leu Ile Asp Arg Asp Glu Phe Ala 
            820                 825                 830         


Lys Trp Phe Val Glu Tyr Leu Glu Asn Lys Asp Tyr Gln Lys Phe Tyr 
        835                 840                 845             


Asn Ser Glu Glu Tyr Arg Ile Arg Asp Ala Asp Phe Lys Lys Asn Ala 
    850                 855                 860                 


Val Ile Lys Lys Gln Lys Leu Lys Asp Phe Tyr Thr Leu Gln Met Val 
865                 870                 875                 880 


Asn Tyr Leu Leu Lys Glu Val Phe Gly Lys Asp Glu Met Asn Leu Gln 
                885                 890                 895     


Leu Ser Glu Leu Phe Gln Thr Arg Gln Glu Arg Leu Lys Leu Gln Gly 
            900                 905                 910         


Ile Ala Lys Lys Gln Met Asn Lys Glu Thr Gly Asp Ser Ser Glu Asn 
        915                 920                 925             


Thr Arg Asn Gln Thr Tyr Ile Trp Asn Lys Asp Val Pro Val Ser Phe 
    930                 935                 940                 


Phe Asn Gly Lys Val Thr Ile Asp Lys Val Lys Leu Lys Asn Ile Gly 
945                 950                 955                 960 


Lys Tyr Lys Arg Tyr Glu Arg Asp Glu Arg Val Lys Thr Phe Ile Gly 
                965                 970                 975     


Tyr Glu Val Asp Glu Lys Trp Met Met Tyr Leu Pro His Asn Trp Lys 
            980                 985                 990         


Asp Arg Tyr Ser Val Lys Pro Ile  Asn Val Ile Asp Leu  Gln Ile Gln 
        995                 1000                 1005             


Glu Tyr  Glu Glu Ile Arg Ser  His Glu Leu Leu Lys  Glu Ile Gln 
    1010                 1015                 1020             


Asn Leu  Glu Gln Tyr Ile Tyr  Asp His Thr Thr Asp  Lys Asn Thr 
    1025                 1030                 1035             


Leu Leu  Gln Asp Gly Asn Pro  Asn Phe Lys Met Tyr  Val Leu Asn 
    1040                 1045                 1050             


Gly Leu  Leu Thr Gly Ile Lys  Gln Val Asn Ile Ala  Asp Phe Ile 
    1055                 1060                 1065             


Val Leu  Lys Gln Asn Thr Asn  Phe Asp Lys Ile Asp  Phe Thr Gly 
    1070                 1075                 1080             


Ile Ala  Ser Cys Ser Glu Leu  Glu Lys Lys Thr Ile  Ile Leu Ile 
    1085                 1090                 1095             


Ala Ile  Arg Asn Lys Phe Ala  His Asn Gln Leu Pro  Asn Lys Thr 
    1100                 1105                 1110             


Ile Tyr  Asp Leu Ala Asn Glu  Phe Leu Lys Lys Glu  Lys Arg Glu 
    1115                 1120                 1125             


Thr Tyr  Ala Asn Tyr Tyr Leu  Lys Val Leu Lys Lys  Met Ile Ser 
    1130                 1135                 1140             


Asp Leu  Ala 
    1145     


<210>  1462
<211>  1129
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1462

Met Glu Thr Asn Gln Gln Thr His Glu Asn Arg Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Asn Asn His Val Ala Thr Asp Phe Lys Arg Lys Pro 
        35                  40                  45              


Leu Pro Glu Glu Gly His Ile Pro Asp Ala Leu Leu Cys Asn Lys Thr 
    50                  55                  60                  


Ile Lys Asn Leu Asn Trp Asn His Val His Thr Arg Ala Leu Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ser Glu Ser Leu Pro Lys Asp Glu 
                85                  90                  95      


Arg Glu Asn Ser Asp Thr Glu Gly Lys Asp Phe Thr Ser Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Ser Glu Leu Gln Asp Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Asp Ser Arg Lys Leu Ile Val 
    130                 135                 140                 


Ser Pro Glu Leu Ala Asn Phe Leu Thr Val Asn Phe Gln Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Ala Arg Met Lys Asp Val Leu Thr Asp Thr Asp Tyr 
                165                 170                 175     


Ala Leu Val Glu Asn Leu Gln Met Val Ala Pro Asp Asn Lys Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ala Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Thr Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asn Leu Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Ser 
            260                 265                 270         


Val Ile Thr Asp Lys Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Asp Asp Glu Arg 
    290                 295                 300                 


Glu Thr Ile Leu Asp Glu Ile Asp Tyr Gln Asp Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg Tyr Ser Asp Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Asp Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Asn Tyr Thr Lys Gln Phe Ala Gly Glu 
        355                 360                 365             


Gln Ala Glu Arg Lys Val Leu Glu Asn Ala Asn Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asp Pro Glu Leu Ile Gln Gln Arg Ile Asp Lys Gln 
385                 390                 395                 400 


Gln His Thr Ala Gly Phe Asp Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Thr Lys Glu Asn Ile Ala Thr Leu Ile 
            420                 425                 430         


Ala Lys Ser Lys Ala Ser Ser Lys Val Glu His Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Gln Ala Glu Glu Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Ile Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Ser Gln Leu Pro Ala Asn Trp Asp Glu Phe Ser Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asp Ser Thr Leu Lys Tyr Leu 
        515                 520                 525             


Arg Gln Arg Lys Thr Thr Leu Asn Thr Ile Leu Ser Lys Ser Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Lys Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Thr Arg Leu Lys Ala Val Glu Lys His Lys Leu 
            580                 585                 590         


Asn Lys Ser Val Lys Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Glu Glu Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Ala Asn Ala Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Asn Asp Gly His Pro Phe Leu Gln Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Gln Ala Tyr Leu Ile 
        675                 680                 685             


Glu Lys Gly Asn Lys Met Val Pro Arg Leu Asn Pro Lys Thr Asn Lys 
    690                 695                 700                 


Thr Ser Lys Val Asp Glu Ser Trp Met Met Lys Gln Phe Tyr Val Lys 
705                 710                 715                 720 


Glu Trp Lys Glu Glu Ile Gly Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Ser Arg Ile Pro Phe Thr Ile Cys Gln Trp Asp Lys Lys 
            740                 745                 750         


Glu Ser His Asp Leu Asn Thr Trp Leu Gln His Val Thr Val Gly Lys 
        755                 760                 765             


Asn Lys Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe Asp 
    770                 775                 780                 


Glu Ala Leu Cys Asp Leu Leu Arg Glu Gln Leu Asp Thr Lys Ile Val 
785                 790                 795                 800 


Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Ile Trp Trp 
                805                 810                 815     


Lys Thr Arg Asn Asp Asp Thr Gln Gln Phe Tyr Gln Ser Glu Arg Glu 
            820                 825                 830         


Tyr Asp Ile Tyr Asn Glu Lys Val Arg Phe Lys Ile Asp Ser Ser Ala 
        835                 840                 845             


His Phe Ala Asp Tyr Tyr Lys Asn Ala Leu Ser Arg Ala Phe Thr Arg 
    850                 855                 860                 


Leu Lys Ala Glu Arg Glu Thr Ala Arg Gln Thr Asn Lys Lys Leu Pro 
865                 870                 875                 880 


Pro Leu Glu Tyr Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile Ala 
                885                 890                 895     


Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met Ala 
            900                 905                 910         


Val Leu Met Leu Glu Arg Leu Met Asp Asn Ser Pro Asn Leu Arg Leu 
        915                 920                 925             


Ser Lys Ile Glu Thr Leu Leu Asn Asp Thr Thr His Ile Ser Glu Lys 
    930                 935                 940                 


Ile Ser Ala Thr Leu Ser Phe Asp Ala Ser Gly Glu Arg Ile Ser Gly 
945                 950                 955                 960 


Lys Leu Lys Gln Thr Val Thr Lys Thr Leu Ile Ala Glu Arg Lys Gln 
                965                 970                 975     


Lys Asn Tyr Thr Glu Leu Arg Lys Tyr Arg Tyr Asp Arg Arg Leu Pro 
            980                 985                 990         


Glu Leu Phe Glu Tyr Val Gln Ala  Asp Glu Ile Pro Leu  Glu Trp Leu 
        995                 1000                 1005             


Leu Glu  Glu Leu Ser Ala Tyr  Asn Asn Ala Lys Gln  Gln Val Phe 
    1010                 1015                 1020             


Asp Thr  Val Phe Ala Leu Glu  Lys Lys Ile Val Gly  Thr Asp Pro 
    1025                 1030                 1035             


Asp Gly  Leu Lys Ser Leu Phe  Thr Asn Pro Lys Gly  Glu Pro Leu 
    1040                 1045                 1050             


Lys Gly  Asn Ile Gln His Lys  Pro Tyr Val Gln Trp  Leu Thr Asn 
    1055                 1060                 1065             


Lys Gly  Leu Ile Asn Lys Glu  Glu Lys Gln Phe Ile  Asn Met Val 
    1070                 1075                 1080             


Arg Lys  Cys Phe Ser His Asn  Gln Phe Pro Gln Arg  Lys Thr Met 
    1085                 1090                 1095             


Glu Leu  Leu Ile Pro Ala Trp  Asn Glu Lys Lys Leu  Ala Leu Gln 
    1100                 1105                 1110             


Ile Ala  Thr Val Tyr Asn Gln  Leu Ile Ala Asp Leu  Thr Asp Lys 
    1115                 1120                 1125             


Ile 
    


<210>  1463
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1463

Met Glu Thr Lys Gln Gln Val Gly Lys Gly Ile Ser Tyr Asp His Arg 
1               5                   10                  15      


Arg Pro Asp Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asp Gly Val Ile Gln Glu Phe Ala Met Arg Leu Asn Arg 
        35                  40                  45              


Glu Tyr Asp Pro Glu Asn Lys Asn Gln Ser Leu Phe Ser Tyr Phe Asn 
    50                  55                  60                  


Ile Asn Ala Ser Phe Thr Asp Trp Glu Arg Gly Val Asn Ile Leu Lys 
65                  70                  75                  80  


Glu Tyr Trp Pro Met Met Glu Phe Ile Asp Arg Pro Ala Thr Asp Lys 
                85                  90                  95      


Gln Phe Glu Ala Glu Lys Pro Glu Asn Arg Glu Ala Ala Lys Arg Lys 
            100                 105                 110         


Tyr Phe Leu Ala Thr Leu Gly Ala Leu Leu Thr Ser Ile Lys Asp Leu 
        115                 120                 125             


Arg His Tyr Tyr Thr His Tyr Tyr His Pro Pro Val His Leu Asn Asp 
    130                 135                 140                 


Asp Leu Phe Leu Phe Leu Asp His Ala Leu Leu Tyr Thr Ala Phe Asp 
145                 150                 155                 160 


Val Lys Lys Thr Lys Met Lys Asp Asp Lys Thr Arg Gln Leu Leu Asn 
                165                 170                 175     


Gln Asn Leu Ser Leu Glu Leu Glu Lys Leu Lys Lys Leu Lys Val Glu 
            180                 185                 190         


Glu Leu Lys Lys Lys Lys Glu Lys Gly Ile Lys Val Asn Leu Gln Asp 
        195                 200                 205             


Glu Lys Gly Ile Leu Asn Ala Ile Tyr Asn Asp Ala Phe Ala His Ile 
    210                 215                 220                 


Ile Thr Lys Glu Lys Asp Ser Asp Lys Asp Lys Leu Glu Thr Arg Tyr 
225                 230                 235                 240 


Lys Ser Ile Leu Pro Gln Asp Glu Ala Ala Glu Thr Gly Ile Asn Ile 
                245                 250                 255     


Ser Ile Ser Gly Leu Ile Phe Leu Leu Ser Leu Phe Leu Ser Arg Lys 
            260                 265                 270         


Glu Ile Glu Gln Leu Lys Ser Asn Ile Glu Gly Tyr Lys Gly Lys Val 
        275                 280                 285             


Leu Asn Ile Glu Thr Glu Val Asp Arg Lys His Asn Ser Leu Lys Tyr 
    290                 295                 300                 


Met Ala Thr His Trp Val Phe Ser Ile Leu Ala Phe Lys Gly Leu Lys 
305                 310                 315                 320 


Gln Arg Leu Thr Asn Ser Phe Glu Lys Glu Ser Leu Leu Ile Gln Met 
                325                 330                 335     


Met Asp Glu Leu Asn Lys Val Pro Asp Glu Leu Tyr Gln Thr Leu Ser 
            340                 345                 350         


Glu Thr Ala Lys Lys Glu Phe Leu Glu Asp Ile Asn Glu Tyr Val Ser 
        355                 360                 365             


Glu Gly Asp Asp Asn Glu Lys Ala Thr Tyr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Ser Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gln Phe Pro Thr Leu Lys Phe Gln Ile Phe Val Gly 
                405                 410                 415     


Gln Tyr Leu His Asp Asn Arg Pro Lys Thr Leu Ala Ser Asn Gly Met 
            420                 425                 430         


Thr Ala Gln Arg Met Ile Lys Glu Lys Ile Asn Leu Phe Gly Asn Leu 
        435                 440                 445             


Ser Glu Val Thr Lys His Lys Ser Asp Phe Phe Glu Lys Glu Ser Ala 
    450                 455                 460                 


Ala Gln Gly Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Trp Ala Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Val Tyr Ile Asp Met Ile Gly Lys Glu Gly Lys Ala 
                485                 490                 495     


Lys Glu Ile Gln Val Gln Ile Asn Lys Tyr Arg Lys Gln Leu Asn Pro 
            500                 505                 510         


Ala Pro Gln Arg Asp Lys Arg Ile Ser Lys Lys Glu Ile Ile Glu Gln 
        515                 520                 525             


Leu Tyr Lys Glu Lys Val Val Tyr Gly Asp Pro Thr Leu Met Leu Ser 
    530                 535                 540                 


Ala Asn Glu Leu Met Ala Leu Leu Tyr Glu Leu Ile Val Asn Gly Lys 
545                 550                 555                 560 


Ser Gly Ala Glu Leu Glu Asn Lys Ile Val Glu Gln Ile Ile Ala Arg 
                565                 570                 575     


Tyr Glu Gln Ile Glu Ala Tyr Asp Pro Thr Thr Gln Gln Leu Pro Thr 
            580                 585                 590         


Asn Gln Met Pro His Lys Leu Gln Lys Ser Arg Lys Asp Ser Lys Val 
        595                 600                 605             


Thr Asp Thr Asp Lys Leu Leu Lys Thr Ile Asp Lys Glu Ile Asp Glu 
    610                 615                 620                 


Gly Asn Lys Lys Leu Glu Leu Ile Ala Cys His Arg Lys Glu Trp Glu 
625                 630                 635                 640 


Glu Ala Glu Gln Arg Lys Lys Ser Gly Lys Arg Asn Asn Pro Gly Thr 
                645                 650                 655     


Lys Ser Arg Lys His Leu Phe Tyr Ala Ser Glu Met Gly Glu Glu Ala 
            660                 665                 670         


Thr Trp Ile Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Pro Ala Arg 
        675                 680                 685             


Ala Glu Trp Lys Gly Thr His His Ser Glu Leu Gln Arg Leu Leu Ala 
    690                 695                 700                 


Phe Tyr Ser Thr Gln Arg Leu Glu Ala Trp Gln Leu Val Glu Ser Val 
705                 710                 715                 720 


Trp Thr Ala Asn Thr His Ser Phe Trp Glu Glu Asn Phe Lys Glu Ala 
                725                 730                 735     


Phe Tyr Lys Pro Glu Phe Glu Asn Phe Tyr Gly Ala Tyr Ile Glu Ile 
            740                 745                 750         


Arg Thr Lys Ile Leu Thr Thr Cys Arg Ser Ile Leu Glu Asn Asn Pro 
        755                 760                 765             


Glu Ala Thr Met Asn Asn Asp Thr Glu Lys Glu Trp Asp Lys Val Phe 
    770                 775                 780                 


Thr Leu Phe Asp Lys Arg Leu Tyr Arg Thr Ser Thr Thr Asp Glu Gln 
785                 790                 795                 800 


Lys Lys Gln Leu Leu Thr Lys Pro Phe Ala Phe Pro Arg Gly Leu Phe 
                805                 810                 815     


Asp Asp Lys Pro Thr Phe Leu Pro Gly Ser Lys Pro Asn Glu Asn Pro 
            820                 825                 830         


Glu Arg Phe Ala Ala Trp Tyr Ser Tyr Gly Tyr Thr Tyr Ser Gly Lys 
        835                 840                 845             


Phe Gln Ser Phe Tyr Asp Met Pro Arg Asn Tyr Ser Asp Trp Tyr Lys 
    850                 855                 860                 


Lys Leu Lys Glu Asp Gly Lys Leu Pro Arg Leu Asp Lys Lys Thr Glu 
865                 870                 875                 880 


Gln Glu Lys Ile Leu Arg Phe Arg Met Asp Cys Asp Leu Asn Ile Lys 
                885                 890                 895     


His Ile Arg Phe Gln Asp Ile Tyr Val Lys Leu Met Val Asp Ser Leu 
            900                 905                 910         


Tyr Lys Ala Val Phe Gly Gln Gln Pro Glu Phe Asp Leu Ser His Leu 
        915                 920                 925             


Tyr Asp Thr Arg Ser Glu Arg Tyr Glu Asn Asn Thr Ile Ala Gln Arg 
    930                 935                 940                 


Gln Lys Ser Arg Gln Glu Gly Asp Asn Ser Asp Asn Ala Ile Asn Glu 
945                 950                 955                 960 


Asn Tyr Val Trp Asn Lys Thr Phe Ala Ile Ser Leu Tyr Asn Gly Arg 
                965                 970                 975     


Ile Thr Glu Ser Gln Val Lys Leu Lys Asp Val Gly Lys Phe Arg Arg 
            980                 985                 990         


Phe Ala Thr Asp Pro Arg Val Gln  Thr Leu Ile Ser Tyr  Asp Asp Thr 
        995                 1000                 1005             


Arg Thr  Trp Thr Lys Leu Glu  Ile Glu Asn Glu Leu  Asp Asn Lys 
    1010                 1015                 1020             


Ala Asp  Ala Tyr Glu Pro Ile  Arg Arg Thr Gln Ser  Leu Lys Ala 
    1025                 1030                 1035             


Ile Gln  Gln Leu Glu Lys Asn  Ile Leu Lys Lys Asn  Gly Phe Asn 
    1040                 1045                 1050             


Gly Lys  Gln His Pro Glu Glu  Leu Lys His Asn Gly  Asn Pro Asn 
    1055                 1060                 1065             


Phe Arg  Lys Tyr Ile Ala Asn  Gly Leu Leu Lys His  Arg Thr Asp 
    1070                 1075                 1080             


Ile Arg  Gln Glu Glu Leu Ala  Leu Ile Ser Asp Thr  Glu Phe Gln 
    1085                 1090                 1095             


Glu Ile  Gly Leu Glu Arg Ile  Arg Gln Thr Asn Pro  Leu Ile Gln 
    1100                 1105                 1110             


Lys Ala  Tyr Leu Leu Ile Leu  Leu Arg Asn Lys Phe  Gly His Asn 
    1115                 1120                 1125             


Gln Leu  Pro Asp Gln Glu His  Phe Arg Leu Met Arg  Ser Ile Tyr 
    1130                 1135                 1140             


Pro Tyr  Asn Gln Gln Glu Ser  Tyr Ser Ala Tyr Phe  Asn His Val 
    1145                 1150                 1155             


Ile Thr  Gln Ile Ile Glu Glu  Leu Asn Thr 
    1160                 1165             


<210>  1464
<211>  1047
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1464

Met Glu Glu Gln Phe Leu Gln Lys Glu Arg Asn Met Gly Asp Asn Pro 
1               5                   10                  15      


Tyr Tyr Phe Cys His Phe Ile Asn Met Ala His His Asn Val Asn Leu 
            20                  25                  30          


Ile Leu Glu Glu Ile Tyr Asn Ser Val Tyr Glu Lys Tyr Thr Gln Asp 
        35                  40                  45              


Lys Glu Glu Asn Ile Lys Ala Ile Cys Asn Ser Met Ile Ser Lys Ser 
    50                  55                  60                  


Arg Lys Asn Pro Asp Glu Lys Ala Lys Met Met Asn Met Cys Ile Arg 
65                  70                  75                  80  


His Phe Pro Phe Leu Asp Tyr Tyr Lys Glu Lys Asp Gln Asn Ser Asp 
                85                  90                  95      


Val Leu Thr Ile Leu Leu Asn Gln Phe Leu Val Pro Leu His Gly Leu 
            100                 105                 110         


Arg Asn Gln Phe Ser His Tyr Lys His Pro Gln Glu Ala Tyr Cys Ile 
        115                 120                 125             


Ser Gly Phe Asp Leu Leu Phe Glu Gln Ala Lys Thr Gly Ala Gln Met 
    130                 135                 140                 


Arg Met Lys Tyr Ser Asp Glu Asp Ile Ser Lys Val Lys Ser Lys Val 
145                 150                 155                 160 


Val Asn His Asp Ser Ile Leu Thr Glu Arg Gly Ile Leu Phe Phe Ile 
                165                 170                 175     


Cys Leu Phe Leu Asp Lys Arg Asn Ile Tyr Leu Phe Leu Ser Lys Ile 
            180                 185                 190         


Lys Gly Phe Arg Asp Arg Arg Pro Asp Glu Lys Tyr Lys Ser Ala Thr 
        195                 200                 205             


Leu Glu Val Phe Ser Gln Tyr Tyr Cys His Val Pro Tyr Arg Lys Leu 
    210                 215                 220                 


Asp Ser Ser Asp Val Ala Leu Asp Met Leu Asn Glu Leu Asn Arg Cys 
225                 230                 235                 240 


Pro Lys Ala Leu Tyr Asp Val Leu Ser Asp Glu Asp Arg Glu Arg Phe 
                245                 250                 255     


Ile Val Asp Asn Val Glu Asn Ala Asp Asn Arg Asp Glu Ile Ser Asp 
            260                 265                 270         


Glu Asp Asp Glu Glu Met Pro Arg Ser Val Met Lys Arg Ser Asp Asp 
        275                 280                 285             


Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Glu Lys Gln Asn Asn Leu 
    290                 295                 300                 


Asp Glu Ile Ser Phe His Leu Tyr Leu Gly Arg Lys Glu Ala Lys Pro 
305                 310                 315                 320 


Ala His Glu Lys Val Ile Asn Gly Glu Met Arg Thr His Lys Ile Leu 
                325                 330                 335     


Lys Asp Ile His Val Phe Gly Arg Leu Glu Asn Tyr Arg Asn Glu Glu 
            340                 345                 350         


Ile Cys Asn Ala Ile Lys Asn Arg Glu Asp Ile Glu Phe Tyr Ala Pro 
        355                 360                 365             


Ser Tyr Arg Ile Val Glu Asn Arg Ile Gly Leu Leu Leu Arg Arg Gln 
    370                 375                 380                 


Asn Asp Phe Thr Leu Glu Glu Ala Asn Glu Glu Lys Ile Phe Glu Gly 
385                 390                 395                 400 


Asn Leu Cys Pro Asp Val Ile Leu Ser Thr His Glu Leu Gly Ala Leu 
                405                 410                 415     


Phe Phe Tyr Asn Tyr Leu His Lys Lys Gly Trp Ile Glu Ser Ala Pro 
            420                 425                 430         


Tyr Leu Tyr Ile Arg Asn Phe Ile Ser Asp Phe Lys Arg Phe Ile Glu 
        435                 440                 445             


Asp Ile Lys Asn Gly Lys Leu Thr Pro Val Glu Ser Glu Asp Asp Phe 
    450                 455                 460                 


Tyr Leu Ile Lys Lys Lys Lys Arg Asp Glu Thr Lys Asp Asn Asp Lys 
465                 470                 475                 480 


Lys Ser Ile Ala Val Gln Glu Arg Arg Arg Glu Lys Leu Lys Glu Lys 
                485                 490                 495     


Leu Lys Gly Tyr His Leu Glu Pro Asp Trp Ile Pro Asp Ala Cys Arg 
            500                 505                 510         


Glu Tyr Met Leu Gly Tyr Lys Ala Asp Gln Lys Asp Tyr Tyr Thr Lys 
        515                 520                 525             


Gln Arg Phe Cys Ser Met Lys Lys Glu Thr Asp Ser Arg Ile Lys Gln 
    530                 535                 540                 


Ile Glu Ala Ile Arg Lys Arg Glu Asp Asn Ser Ile Ile Arg Gln Thr 
545                 550                 555                 560 


Arg Val Gly Glu Ile Ala Gln Glu Leu Ala Arg Asp Ile Val Phe Leu 
                565                 570                 575     


Ile Pro Pro Tyr Lys Asn Glu Lys Gly Ala Asp Thr Lys Ile Asn Asn 
            580                 585                 590         


Met Glu Phe Asp Val Leu Gln Lys Met Leu Ala Tyr Phe Pro Leu Asn 
        595                 600                 605             


Lys Lys Asp Ile Tyr Pro Phe Leu Lys Asn Ile Arg Asn Trp Asp Lys 
    610                 615                 620                 


His Pro Phe Leu Lys Tyr Thr Leu His Thr Glu His Gln Ser Leu Leu 
625                 630                 635                 640 


Asp Phe Tyr Gln Asp Tyr Leu Asn Cys Lys Lys Arg Trp Ile Ser Lys 
                645                 650                 655     


Asn Ile Arg Tyr Asp Lys Gln Lys Gly Asn Tyr Leu Val Asp Ala Asn 
            660                 665                 670         


Lys Thr Glu Gln Glu Cys Arg Tyr Phe Leu Lys Thr Asp Lys Leu Arg 
        675                 680                 685             


Thr Ala Lys Glu Lys Glu Tyr Phe Glu Glu Pro Asp Lys Pro Val Tyr 
    690                 695                 700                 


Leu Pro Thr Gly Phe Phe Val Asp Pro Ile Val Glu Ala Met Arg Lys 
705                 710                 715                 720 


Asn Gly Tyr Glu Leu Lys Glu Asn Ser Asn Ile Val Gly Cys Leu Lys 
                725                 730                 735     


Ile Tyr Phe Val Ser Lys Ile Gln Pro Met Tyr Asp Leu Ser Arg Tyr 
            740                 745                 750         


Tyr Thr Tyr Tyr Asp Gly Lys Glu Glu Arg Ser Met Gln Leu Asp Asp 
        755                 760                 765             


Leu Lys Val Phe Ile Lys Glu Lys Phe Gly Asn Lys Arg Thr Asp Asp 
    770                 775                 780                 


Asn Thr Ile Arg Phe Leu Lys Lys Ala Ala Lys Arg Ile Arg Glu Asn 
785                 790                 795                 800 


Glu Ser Glu Ile Leu Val Arg Gln Met Asp Asp Cys Ala Leu Phe Leu 
                805                 810                 815     


Met Val Asn Asp Leu Leu Glu Gly Gly Lys Phe Asn Asp Glu Asp Ile 
            820                 825                 830         


Glu Asn Ile Gly Tyr Asn Lys His His Asn Leu Leu Asp His Glu Tyr 
        835                 840                 845             


Asp Met Cys Glu Thr Ile Tyr Gly Arg Lys Val Thr Ala Arg Leu Pro 
    850                 855                 860                 


Ile Lys Arg Tyr Gly Glu Phe Arg Arg Phe Met Lys Asp Arg Arg Leu 
865                 870                 875                 880 


Gln Asn Leu Val Lys Tyr Tyr Pro Gly Asp His Glu Thr Pro Ile Pro 
                885                 890                 895     


Ser Gly Ile Pro Glu Ser Gly Lys Ala Met Glu Lys Asn Lys Lys Tyr 
            900                 905                 910         


Thr Tyr Ser Asn Leu Cys Asp Glu Leu Glu Ile Tyr Asp Lys Glu Arg 
        915                 920                 925             


Asp Asn Val Leu Asn Leu Ile Tyr Glu Val Asp Lys Ile Leu Val Asp 
    930                 935                 940                 


His Phe Pro Asp Lys Ile Met Lys Glu Glu Asp Gly Tyr Tyr Glu His 
945                 950                 955                 960 


Tyr His Cys Leu Asp Phe Ala Lys Lys Glu Phe Gly Leu Glu Ser Asp 
                965                 970                 975     


Val Glu Leu Leu Ser Gln Asp Asn Phe Lys Asp Leu Arg Asn Ala Leu 
            980                 985                 990         


Tyr His Asn Gln Ile Pro Tyr Asn  Asp Trp Val Ala Asp  Lys Ile Ser 
        995                 1000                 1005             


Lys Asp  Thr Glu Glu Pro Met  Tyr Val Arg Arg Ile  Phe Ser Phe 
    1010                 1015                 1020             


Ile Arg  Thr Val Tyr Ser Arg  Leu Leu Asp Gln Ile  Lys Ile Lys 
    1025                 1030                 1035             


Ile Glu  Lys Asp Glu Tyr Lys  Cys Lys 
    1040                 1045         


<210>  1465
<211>  1047
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1465

Met Glu Thr Glu Val Thr Ala Gln Asn Asn Ser Leu Thr Leu Thr Asn 
1               5                   10                  15      


Asn Pro Tyr Tyr Phe Ala His Tyr Ala Asn Met Ala Arg His Asn Ala 
            20                  25                  30          


Tyr Ile Val Leu Asn Glu Ile Asn Glu Lys Ile Tyr Asn Asn Lys Val 
        35                  40                  45              


Lys Ile Pro Glu Asp Gly Leu Ser Glu Cys Lys Leu Val Asn Ser Phe 
    50                  55                  60                  


Ser Lys Lys Asn Lys Lys Ala Asp Glu Tyr Ala Arg Ile Ile Lys Leu 
65                  70                  75                  80  


Leu Thr Glu His Tyr Pro Phe Ile Arg Phe Tyr Ala Asp Ser Ser Lys 
                85                  90                  95      


Glu Met Gly Asn Ile Pro Leu Lys Ala Tyr Leu Asp Ile Leu Asp Lys 
            100                 105                 110         


Ile Arg Asn Glu Asn Asn His Tyr Asn His Thr Ala Glu Arg Lys Glu 
        115                 120                 125             


Ile Ser Lys Ile Gln Glu Leu Phe Leu Phe Ala Lys Glu Lys Ala Lys 
    130                 135                 140                 


Gly Arg Met Ile Glu Phe Ser Pro Glu Asp Phe Asp His Leu Asn Asn 
145                 150                 155                 160 


Ser Lys Tyr Tyr Ala Met Thr Glu Asp Gly Ser Leu Thr Asn Thr Gly 
                165                 170                 175     


Ile Tyr Phe Phe Leu Cys Leu Phe Leu Glu Lys Lys His Ala Phe Gln 
            180                 185                 190         


Phe Leu Ser Arg Ile Lys Gly Phe Lys His Arg Glu Gln Lys Ser His 
        195                 200                 205             


Arg Ala Thr Leu Glu Thr Phe Thr Gln Leu Cys Cys Arg Leu Pro Tyr 
    210                 215                 220                 


Pro Lys Leu Glu Ser Ser Asp Val Ala Leu Asp Met Leu Asn Glu Ile 
225                 230                 235                 240 


Ala Arg Cys Pro Asn Ala Leu Tyr Gly Val Leu Glu Asn Lys Asp Lys 
                245                 250                 255     


Glu Thr Phe Lys Val Glu Phe Lys Asn Gly Ala Thr Asn Asn Glu Met 
            260                 265                 270         


Glu Val Pro Glu Pro Val Met Lys Arg His Asp Asp Arg Phe Pro Tyr 
        275                 280                 285             


Phe Ala Leu Arg Tyr Phe Asp Lys Ser Gln Ala Leu Asp Gly Ile Thr 
    290                 295                 300                 


Ser His Leu Gln Leu Gly Arg Arg Ile Val Ser Asp Pro His Gln Lys 
305                 310                 315                 320 


Lys Ile Gly Ala Glu Val Arg Thr His Glu Ile Leu Lys Asp Met Arg 
                325                 330                 335     


Thr Ala His Gln Leu Ala Tyr Phe Glu Thr Asp Ala Ala Lys Glu Phe 
            340                 345                 350         


Tyr Thr Asn Ile Pro Val Val Glu His Tyr Ala Pro Gln Tyr Arg Ile 
        355                 360                 365             


Val Gly Asn Arg Ile Gly Leu Phe Phe Asp Tyr Glu Cys Trp Gly Lys 
    370                 375                 380                 


Tyr Thr Val Pro Lys Glu Asn Val Lys Pro Asp Ala Ile Ile Ser Ile 
385                 390                 395                 400 


His Asp Leu Gly Ala Leu Tyr Phe Tyr Asn Arg Leu Tyr Lys Glu Gly 
                405                 410                 415     


Ser Val Lys Gln Ser Pro Lys Glu Leu Met Lys Ser Tyr Leu Glu Asn 
            420                 425                 430         


Met Asn Arg Leu Phe Asp Asp Val Lys Lys Gly Asn Ile Lys Pro Val 
        435                 440                 445             


Asn Asp Gly Glu Lys Leu Thr Pro Leu Phe Lys Ile Lys Asp Lys Glu 
    450                 455                 460                 


Asp Glu Tyr Glu Ile Arg Leu Glu Asn Leu Lys Glu Leu Ser Ala Leu 
465                 470                 475                 480 


Leu Gln Thr Glu Leu Asp Lys Arg Gly Tyr Gly Ile Glu Val Lys Asn 
                485                 490                 495     


Leu Pro Asp Val Cys Arg Glu Tyr Leu Leu Gly Tyr Lys Glu Ser Ser 
            500                 505                 510         


Ala Lys Asp Lys Ala Lys Arg Arg Phe Lys Arg Met Leu Arg Glu Thr 
        515                 520                 525             


Gln Phe Ala Leu Lys Lys Val Glu Arg Val Leu Ile Gln Glu Thr Ser 
    530                 535                 540                 


Leu Leu Ala Ser Gly Leu Lys Val Gly Glu Met Ala Gln Glu Leu Ala 
545                 550                 555                 560 


Arg Asp Ile Val Phe Leu Ile Lys Pro Lys Ile Val Lys Lys Ile Ile 
                565                 570                 575     


Lys Ser Gly Thr Asp Ala Gly Lys Glu Val Glu Cys Lys Gln Lys Ile 
            580                 585                 590         


Asn Asn Met Glu Phe Asp Val Leu Gln Lys Met Leu Ala Phe Tyr Pro 
        595                 600                 605             


Val Tyr Lys Glu Glu Ile Glu His Phe Leu Trp Thr Met Val Asn Lys 
    610                 615                 620                 


Arg Asp Pro Asn Ala Phe Ser His Pro Phe Leu Phe Arg Ala Leu Leu 
625                 630                 635                 640 


Lys Ile Lys Thr Cys Arg Asn Leu Asn Asp Phe Tyr Lys Glu Tyr Tyr 
                645                 650                 655     


Leu His Lys Gln Arg Trp Ile Glu Gly Val Ser Lys Ser Ile Thr Pro 
            660                 665                 670         


Glu Val Leu Arg Asp Asn Glu Tyr Phe Leu Lys Leu Glu Asn Gly Asn 
        675                 680                 685             


Ala Phe Pro His Asn Tyr Asn Gly Glu Ala Ile Phe Ile Pro Ser Gly 
    690                 695                 700                 


Phe Phe Asn Lys Glu Ile Thr Arg Ala Met Val Gln Ile Gly Tyr Lys 
705                 710                 715                 720 


Ile Glu Asn Pro Glu Lys Gly Ala Asn Ala Ala Tyr Trp Ile Lys Gln 
                725                 730                 735     


Tyr Phe Glu Gly Lys Ser Gln Pro Phe Tyr Asn Leu Pro Arg Tyr Tyr 
            740                 745                 750         


Asn Glu Ser Leu Gly Gly Lys Glu Pro Val Tyr Ile Glu Arg Asp Lys 
        755                 760                 765             


Leu Lys Lys Gln Ile Leu Glu Gly Asp Phe Asn Arg Leu Thr Glu Asp 
    770                 775                 780                 


Glu Gln Lys Arg Arg Lys Val Leu Ala Lys Arg Ile Arg Glu Asn Glu 
785                 790                 795                 800 


Ser Glu Ile Leu Thr Asn Gln Thr Asn Asp Arg Val Met Tyr Leu Met 
                805                 810                 815     


Ala Met Glu Leu Ile Asp Ser Glu Asn Pro Leu Lys Lys Asn Glu Ile 
            820                 825                 830         


Val Ser Val Gly Tyr Asn Ile Lys Glu Gly Thr Asn Leu Leu Asp Asn 
        835                 840                 845             


Asn Lys Val Ser Trp Asn Ile Gln Gly Arg Arg Val Val Ala Glu Leu 
    850                 855                 860                 


Pro Ile Lys Arg Tyr Gly Glu Tyr Arg Arg Phe Leu Lys Asp Arg Arg 
865                 870                 875                 880 


Leu Glu Asn Leu Leu Lys Tyr Tyr Pro Glu Gly Lys Glu Leu Gln Leu 
                885                 890                 895     


Gly Thr Leu Lys Ser Gly Glu Val Glu Glu Lys Gly Lys Lys Tyr Thr 
            900                 905                 910         


Asn Ser Asn Leu Val Asp Glu Leu Glu Leu Phe Asp Leu Lys Arg Asn 
        915                 920                 925             


Glu Leu Met Glu Gln Val Tyr Leu Phe Glu Lys Ile Leu Cys Thr Asn 
    930                 935                 940                 


Tyr Ala Asp Lys Ile Lys Ala Val Leu Pro Asp Lys Glu Arg Asn Lys 
945                 950                 955                 960 


Pro Tyr Ile Glu His Tyr His Cys Leu Met Tyr Ala Lys Asn Glu Met 
                965                 970                 975     


Lys Leu Phe Lys Glu Val Gly Glu Leu Glu His Glu His Phe Asn Glu 
            980                 985                 990         


Leu Arg Asn Lys Ile Ser His Asn  Gln Met Pro Tyr Thr  Asp Trp Leu 
        995                 1000                 1005             


Met Glu  Arg Val Ile Ala Asn  Lys Glu Glu Pro Met  Ile Thr Asn 
    1010                 1015                 1020             


Arg Ile  Val Asp Leu Ile Leu  Ser Ile Tyr Lys Glu  Leu Asn Ser 
    1025                 1030                 1035             


Gln Leu  Val Ile Ile Thr Asn  Ser Lys 
    1040                 1045         


<210>  1466
<211>  1047
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1466

Met Glu Thr Glu Val Thr Ala Gln Asn Asn Ser Leu Thr Leu Thr Asn 
1               5                   10                  15      


Asn Pro Tyr Tyr Phe Ala His Tyr Ala Asn Met Ala Arg His Asn Ala 
            20                  25                  30          


Tyr Ile Val Leu Asn Glu Ile Asn Glu Lys Ile Tyr Asn Asn Lys Val 
        35                  40                  45              


Lys Ile Pro Glu Asp Gly Leu Ser Glu Cys Lys Leu Val Asn Ser Phe 
    50                  55                  60                  


Ser Lys Lys Asn Lys Lys Ala Asp Glu Tyr Ala Arg Ile Ile Lys Leu 
65                  70                  75                  80  


Leu Thr Glu His Tyr Pro Phe Ile Arg Phe Tyr Ala Asp Ser Ser Lys 
                85                  90                  95      


Glu Met Gly Asn Ile Pro Leu Lys Ala Tyr Leu Asp Ile Leu Asp Lys 
            100                 105                 110         


Ile Arg Asn Glu Asn Asn His Tyr Asn His Thr Ala Glu Arg Lys Glu 
        115                 120                 125             


Ile Ser Lys Ile Gln Glu Leu Phe Leu Phe Ala Lys Glu Lys Ala Lys 
    130                 135                 140                 


Gly Arg Met Ile Glu Phe Ser Pro Glu Asp Phe Asp His Leu Asn Asn 
145                 150                 155                 160 


Ser Lys Tyr Tyr Ala Met Thr Glu Asp Gly Ser Leu Thr Asn Thr Gly 
                165                 170                 175     


Ile Tyr Phe Phe Leu Cys Leu Phe Leu Glu Lys Lys His Ala Phe Gln 
            180                 185                 190         


Phe Leu Ser Arg Ile Lys Gly Phe Lys His Arg Glu Gln Lys Ser His 
        195                 200                 205             


Arg Ala Thr Leu Glu Thr Phe Thr Gln Leu Cys Cys Arg Leu Pro Tyr 
    210                 215                 220                 


Pro Lys Leu Glu Ser Ser Asp Val Ala Leu Asp Met Leu Asn Glu Ile 
225                 230                 235                 240 


Ala Arg Cys Pro Asn Ala Leu Tyr Gly Val Leu Glu Asn Lys Asp Lys 
                245                 250                 255     


Glu Thr Phe Lys Val Glu Phe Lys Asn Gly Ala Thr Asn Asn Glu Met 
            260                 265                 270         


Glu Val Pro Glu Pro Val Met Lys Arg His Asp Asp Arg Phe Pro Tyr 
        275                 280                 285             


Phe Ala Leu Arg Tyr Phe Asp Lys Ser Gln Ala Leu Asp Gly Ile Thr 
    290                 295                 300                 


Ser His Leu Gln Leu Gly Arg Arg Ile Val Ser Asp Pro His Gln Lys 
305                 310                 315                 320 


Lys Ile Gly Ala Glu Val Arg Thr His Glu Ile Leu Lys Asp Met Arg 
                325                 330                 335     


Thr Ala His Gln Leu Ala Tyr Phe Glu Thr Asp Ala Ala Lys Glu Phe 
            340                 345                 350         


Tyr Thr Asn Ile Pro Val Val Glu His Tyr Ala Pro Gln Tyr Arg Ile 
        355                 360                 365             


Val Gly Asn Arg Ile Gly Leu Phe Phe Asp Tyr Glu Cys Trp Gly Lys 
    370                 375                 380                 


Tyr Thr Val Pro Lys Glu Asn Val Lys Pro Asp Ala Ile Ile Ser Ile 
385                 390                 395                 400 


His Asp Leu Gly Ala Leu Tyr Phe Tyr Asn Arg Leu Tyr Lys Glu Gly 
                405                 410                 415     


Ser Val Lys Gln Ser Pro Lys Glu Leu Met Lys Ser Tyr Leu Glu Asn 
            420                 425                 430         


Met Asn Arg Leu Phe Asp Asp Val Lys Lys Gly Asn Ile Lys Pro Val 
        435                 440                 445             


Asn Asp Gly Glu Lys Leu Thr Pro Leu Phe Lys Ile Lys Asp Lys Glu 
    450                 455                 460                 


Asp Glu Tyr Glu Ile Arg Leu Glu Asn Leu Lys Glu Leu Ser Ala Leu 
465                 470                 475                 480 


Leu Gln Thr Glu Leu Asp Lys Arg Gly Tyr Gly Ile Glu Val Lys Asn 
                485                 490                 495     


Leu Pro Asp Val Cys Arg Glu Tyr Leu Leu Gly Tyr Lys Glu Ser Ser 
            500                 505                 510         


Ala Lys Asp Lys Ala Lys Arg Arg Phe Lys Arg Met Leu Arg Glu Thr 
        515                 520                 525             


Gln Phe Ala Leu Lys Lys Val Glu Arg Val Leu Ile Gln Glu Thr Ser 
    530                 535                 540                 


Leu Leu Ala Ser Gly Leu Lys Val Gly Glu Met Ala Gln Glu Leu Ala 
545                 550                 555                 560 


Arg Asp Ile Val Phe Leu Ile Lys Pro Lys Ile Val Lys Lys Ile Ile 
                565                 570                 575     


Lys Ser Gly Thr Asp Ala Gly Lys Glu Val Glu Cys Lys Gln Lys Ile 
            580                 585                 590         


Asn Asn Met Glu Phe Asp Val Leu Gln Lys Met Leu Ala Phe Tyr Pro 
        595                 600                 605             


Val Tyr Lys Glu Glu Ile Glu His Phe Leu Trp Thr Met Val Asn Lys 
    610                 615                 620                 


Arg Asp Pro Asn Ala Phe Ser His Pro Phe Leu Phe Arg Ala Leu Leu 
625                 630                 635                 640 


Lys Ile Lys Thr Cys Arg Asn Leu Asn Asp Phe Tyr Lys Glu Tyr Tyr 
                645                 650                 655     


Leu His Lys Gln Arg Trp Ile Glu Gly Val Ser Lys Ser Ile Thr Pro 
            660                 665                 670         


Glu Val Leu Arg Asp Asn Glu Tyr Phe Leu Lys Leu Glu Asn Gly Asn 
        675                 680                 685             


Ala Phe Pro His Asn Tyr Asn Gly Glu Ala Ile Phe Ile Pro Ser Gly 
    690                 695                 700                 


Phe Phe Asn Lys Glu Ile Thr Arg Ala Met Val Gln Ile Gly Tyr Lys 
705                 710                 715                 720 


Ile Glu Asn Pro Glu Lys Gly Ala Asn Ala Ala Tyr Trp Ile Lys Gln 
                725                 730                 735     


Tyr Phe Glu Gly Lys Ser Gln Pro Phe Tyr Asn Leu Pro Arg Tyr Tyr 
            740                 745                 750         


Asn Glu Ser Leu Gly Gly Lys Glu Pro Val Tyr Ile Glu Arg Asp Lys 
        755                 760                 765             


Leu Lys Lys Gln Ile Leu Glu Gly Asp Phe Asn Arg Leu Thr Glu Asp 
    770                 775                 780                 


Glu Gln Lys Arg Arg Lys Val Leu Ala Lys Arg Ile Arg Glu Asn Glu 
785                 790                 795                 800 


Ser Glu Ile Leu Thr Asn Gln Thr Asn Asp Arg Val Met Tyr Leu Met 
                805                 810                 815     


Ala Met Glu Leu Ile Asp Ser Glu Asn Pro Leu Lys Lys Asn Glu Ile 
            820                 825                 830         


Val Ser Val Gly Tyr Asn Ile Lys Glu Gly Thr Asn Leu Leu Asp Asn 
        835                 840                 845             


Asn Lys Val Ser Trp Asn Ile Gln Gly Arg Arg Val Val Ala Glu Leu 
    850                 855                 860                 


Pro Ile Lys Arg Tyr Gly Glu Tyr Arg Arg Phe Leu Lys Asp Arg Arg 
865                 870                 875                 880 


Leu Glu Asn Leu Leu Lys Tyr Tyr Pro Glu Gly Lys Glu Leu Gln Leu 
                885                 890                 895     


Gly Thr Leu Lys Ser Gly Glu Val Glu Glu Lys Gly Lys Lys Tyr Thr 
            900                 905                 910         


Asn Ser Asn Leu Val Asp Glu Leu Glu Leu Phe Asp Leu Lys Arg Asn 
        915                 920                 925             


Glu Leu Met Glu Gln Val Tyr Leu Phe Glu Lys Ile Leu Cys Thr Asn 
    930                 935                 940                 


Tyr Ala Asp Lys Ile Lys Ala Val Leu Pro Asp Lys Glu Arg Asn Lys 
945                 950                 955                 960 


Pro Tyr Ile Glu His Tyr His Cys Leu Met Tyr Ala Lys Asn Glu Met 
                965                 970                 975     


Lys Leu Phe Lys Glu Val Gly Glu Leu Glu His Glu His Phe Asn Glu 
            980                 985                 990         


Leu Arg Asn Lys Ile Ser His Asn  Gln Met Pro Tyr Thr  Asp Trp Leu 
        995                 1000                 1005             


Met Glu  Arg Val Ile Ala Asn  Lys Glu Glu Pro Met  Ile Thr Asn 
    1010                 1015                 1020             


Arg Ile  Val Asp Leu Ile Leu  Ser Ile Tyr Lys Glu  Leu Asn Ser 
    1025                 1030                 1035             


Gln Leu  Val Ile Ile Thr Asn  Ser Lys 
    1040                 1045         


<210>  1467
<211>  1175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1467

Met Thr Glu Gln Asn Glu Lys Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Ala His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Cys Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Gly Thr Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Ala Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Ala 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Phe Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Glu Glu Val 
            500                 505                 510         


Ser Ala Glu Lys Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Asp Glu Ile Asn Thr Arg Asp 
    530                 535                 540                 


Glu Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Gly Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Tyr Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Asp Leu Glu Ala Trp Ser Gln Ser Thr Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Ala Gly Ile Lys Tyr Ala Ser Trp Glu Asn 
    850                 855                 860                 


Lys Lys Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Glu Ala 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Lys Ala Asp Lys Ile Asn Ile Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Ala Lys Glu His Pro Tyr Leu Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asp Ile Arg Thr 
945                 950                 955                 960 


Asp Val Gln Glu Gln Gly Ser Leu Asn Val Leu Asn Arg Val Lys Pro 
                965                 970                 975     


Met Arg Leu Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val 
            980                 985                 990         


His Lys Glu Gln Ala Pro Leu Ala  Thr Val Tyr Ile Glu  Glu Arg Asp 
        995                 1000                 1005             


Thr Lys  Leu Leu Lys Gln Gly  Asn Phe Lys Ser Phe  Val Lys Asp 
    1010                 1015                 1020             


Arg Arg  Leu Asn Gly Leu Phe  Ser Phe Val Asp Thr  Gly Gly Leu 
    1025                 1030                 1035             


Ala Met  Glu Gln Tyr Pro Ile  Ser Lys Leu Arg Val  Glu Tyr Glu 
    1040                 1045                 1050             


Leu Ala  Lys Tyr Gln Thr Ala  Arg Val Cys Ala Phe  Glu Gln Thr 
    1055                 1060                 1065             


Leu Glu  Leu Glu Glu Ser Leu  Leu Thr Arg Tyr Pro  His Leu Pro 
    1070                 1075                 1080             


Asp Lys  Asn Phe Arg Glu Met  Leu Glu Ser Trp Ser  Asp Pro Leu 
    1085                 1090                 1095             


Leu Asp  Lys Trp Pro Asp Leu  Gln Arg Glu Val Arg  Leu Leu Ile 
    1100                 1105                 1110             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1115                 1120                 1125             


Glu Thr  Leu Phe Ser Ser Ile  Arg Lys Tyr Asp Pro  Ser Ser Pro 
    1130                 1135                 1140             


Asp Ala  Ile Glu Glu Arg Met  Gly Leu Asn Ile Ala  His Arg Leu 
    1145                 1150                 1155             


Ser Glu  Glu Val Lys Gln Ala  Lys Glu Met Ala Glu  Arg Ile Ile 
    1160                 1165                 1170             


Gln Val  
    1175 


<210>  1468
<211>  1184
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1468

Met Glu Arg Ile Phe Gly His Cys Cys Pro His His Asp Ser Val Cys 
1               5                   10                  15      


Phe Val Arg Phe Leu Gly Thr Met Val Ser Asn Gln Asp Gly Arg Glu 
            20                  25                  30          


Asn Val Leu Asp Ile Leu Tyr Ile Ala Asp Arg Thr Arg Lys Leu Lys 
        35                  40                  45              


Pro Met Asn Thr Val Pro Ala Ser Glu Asn Lys Gly Gln Ser Arg Thr 
    50                  55                  60                  


Val Glu Asp Asp Pro Gln Tyr Phe Gly Leu Tyr Leu Asn Leu Ala Arg 
65                  70                  75                  80  


Glu Asn Leu Ile Glu Val Glu Ser His Val Arg Ile Lys Phe Gly Lys 
                85                  90                  95      


Lys Lys Leu Asn Glu Glu Ser Leu Lys Gln Ser Leu Leu Cys Asp His 
            100                 105                 110         


Leu Leu Ser Val Asp Arg Trp Thr Lys Val Tyr Gly His Ser Arg Arg 
        115                 120                 125             


Tyr Leu Pro Phe Leu His Tyr Phe Asp Pro Asp Ser Gln Ile Glu Lys 
    130                 135                 140                 


Asp His Asp Ser Lys Thr Gly Val Asp Pro Asp Ser Ala Gln Arg Leu 
145                 150                 155                 160 


Ile Arg Glu Leu Tyr Ser Leu Leu Asp Phe Leu Arg Asn Asp Phe Ser 
                165                 170                 175     


His Asn Arg Leu Asp Gly Thr Thr Phe Glu His Leu Glu Val Ser Pro 
            180                 185                 190         


Asp Ile Ser Ser Phe Ile Thr Gly Thr Tyr Ser Leu Ala Cys Gly Arg 
        195                 200                 205             


Ala Gln Ser Arg Phe Ala Asp Phe Phe Lys Pro Asp Asp Phe Val Leu 
    210                 215                 220                 


Ala Lys Asn Arg Lys Glu Gln Leu Ile Ser Val Ala Asp Gly Lys Glu 
225                 230                 235                 240 


Cys Leu Thr Val Ser Gly Leu Ala Phe Phe Ile Cys Leu Phe Leu Asp 
                245                 250                 255     


Arg Glu Gln Ala Ser Gly Met Leu Ser Arg Ile Arg Gly Phe Lys Arg 
            260                 265                 270         


Thr Asp Glu Asn Trp Ala Arg Ala Val His Glu Thr Phe Cys Asp Leu 
        275                 280                 285             


Cys Ile Arg His Pro His Asp Arg Leu Glu Ser Ser Asn Thr Lys Glu 
    290                 295                 300                 


Ala Leu Leu Leu Asp Met Leu Asn Glu Leu Asn Arg Cys Pro Arg Ile 
305                 310                 315                 320 


Leu Tyr Asp Met Leu Pro Glu Glu Glu Arg Ala Gln Phe Leu Pro Ala 
                325                 330                 335     


Leu Asp Glu Asn Ser Met Asn Asn Leu Ser Glu Asn Ser Leu Asn Glu 
            340                 345                 350         


Glu Ser Arg Leu Leu Trp Asp Gly Ser Ser Asp Trp Ala Glu Ala Leu 
        355                 360                 365             


Thr Lys Arg Ile Arg His Gln Asp Arg Phe Pro Tyr Leu Met Leu Arg 
    370                 375                 380                 


Phe Ile Glu Glu Met Asp Leu Leu Lys Gly Ile Arg Phe Arg Val Asp 
385                 390                 395                 400 


Leu Gly Glu Ile Glu Leu Asp Ser Tyr Ser Lys Lys Val Gly Arg Asn 
                405                 410                 415     


Gly Glu Tyr Asp Arg Thr Ile Thr Asp His Ala Leu Ala Phe Gly Lys 
            420                 425                 430         


Leu Ser Asp Phe Gln Asn Glu Glu Glu Val Ser Arg Met Ile Ser Gly 
        435                 440                 445             


Glu Ala Ser Tyr Pro Val Arg Phe Ser Leu Phe Ala Pro Arg Tyr Ala 
    450                 455                 460                 


Ile Tyr Asp Asn Lys Ile Gly Tyr Cys His Thr Ser Asp Pro Val Tyr 
465                 470                 475                 480 


Pro Lys Ser Lys Thr Gly Glu Lys Arg Ala Leu Ser Asn Pro Arg Ser 
                485                 490                 495     


Met Gly Phe Ile Ser Val His Asp Leu Arg Lys Leu Leu Leu Met Glu 
            500                 505                 510         


Leu Leu Cys Glu Gly Ser Phe Ser Arg Met Gln Ser Asp Phe Leu Arg 
        515                 520                 525             


Lys Ala Asn Arg Ile Leu Asp Glu Thr Ala Glu Gly Lys Leu Gln Phe 
    530                 535                 540                 


Ser Ala Leu Phe Pro Glu Met Arg His Arg Phe Ile Pro Pro Gln Asn 
545                 550                 555                 560 


Pro Lys Ser Lys Asp Arg Arg Glu Lys Ala Glu Thr Thr Leu Glu Lys 
                565                 570                 575     


Tyr Lys Gln Glu Ile Lys Gly Arg Lys Asp Lys Leu Asn Ser Gln Leu 
            580                 585                 590         


Leu Ser Ala Phe Asp Met Asp Gln Arg Gln Leu Pro Ser Arg Leu Leu 
        595                 600                 605             


Asp Glu Trp Met Asn Ile Arg Pro Ala Ser His Ser Val Lys Leu Arg 
    610                 615                 620                 


Thr Tyr Val Lys Gln Leu Asn Glu Asp Cys Arg Leu Arg Leu Arg Lys 
625                 630                 635                 640 


Phe Arg Lys Asp Gly Asp Gly Lys Ala Arg Ala Ile Pro Leu Val Gly 
                645                 650                 655     


Glu Met Ala Thr Phe Leu Ser Gln Asp Ile Val Arg Met Ile Ile Ser 
            660                 665                 670         


Glu Glu Thr Lys Lys Leu Ile Thr Ser Ala Tyr Tyr Asn Glu Met Gln 
        675                 680                 685             


Arg Ser Leu Ala Gln Tyr Ala Gly Glu Glu Asn Arg Arg Gln Phe Arg 
    690                 695                 700                 


Ala Ile Val Ala Glu Leu Arg Leu Leu Asp Pro Ser Ser Gly His Pro 
705                 710                 715                 720 


Phe Leu Ser Ala Thr Met Glu Thr Ala His Arg Tyr Thr Glu Asp Phe 
                725                 730                 735     


Tyr Lys Cys Tyr Leu Glu Lys Lys Arg Glu Trp Leu Ala Lys Thr Phe 
            740                 745                 750         


Tyr Arg Pro Glu Gln Asp Glu Asn Thr Lys Arg Arg Ile Ser Val Phe 
        755                 760                 765             


Phe Val Pro Asp Gly Glu Ala Arg Lys Leu Leu Pro Leu Leu Ile Arg 
    770                 775                 780                 


Arg Arg Met Lys Glu Gln Asn Asp Leu Gln Asp Trp Ile Arg Asn Lys 
785                 790                 795                 800 


Gln Ala His Pro Ile Asp Leu Pro Ser His Leu Phe Asp Ser Lys Ile 
                805                 810                 815     


Met Glu Leu Leu Lys Val Lys Asp Gly Lys Lys Lys Trp Asn Glu Ala 
            820                 825                 830         


Phe Lys Asp Trp Trp Ser Thr Lys Tyr Pro Asp Gly Met Gln Pro Phe 
        835                 840                 845             


Tyr Gly Leu Arg Arg Glu Leu Asn Ile His Gly Lys Ser Val Ser Tyr 
    850                 855                 860                 


Ile Pro Ser Asp Gly Lys Lys Phe Ala Asp Cys Tyr Thr His Leu Met 
865                 870                 875                 880 


Glu Lys Thr Val Arg Asp Lys Lys Arg Glu Leu Arg Thr Ala Gly Lys 
                885                 890                 895     


Pro Val Pro Pro Asp Leu Ala Ala Asp Ile Lys Arg Ser Phe His Arg 
            900                 905                 910         


Ala Val Asn Glu Arg Glu Phe Met Leu Arg Leu Val Gln Glu Asp Asp 
        915                 920                 925             


Arg Leu Met Leu Met Ala Ile Asn Lys Met Met Thr Asp Arg Glu Glu 
    930                 935                 940                 


Asp Ile Leu Pro Gly Leu Lys Asn Ile Asp Ser Ile Leu Asp Glu Glu 
945                 950                 955                 960 


Asn Gln Phe Ser Leu Ala Val His Ala Lys Val Leu Glu Lys Glu Gly 
                965                 970                 975     


Glu Gly Gly Asp Asn Ser Leu Ser Leu Val Pro Ala Thr Ile Glu Ile 
            980                 985                 990         


Lys Ser Lys Arg Lys Asp Trp Ser  Lys Tyr Ile Arg Tyr  Arg Tyr Asp 
        995                 1000                 1005             


Arg Arg  Val Pro Gly Leu Met  Ser His Phe Pro Glu  His Lys Ala 
    1010                 1015                 1020             


Thr Leu  Asp Glu Val Lys Thr  Leu Leu Gly Glu Tyr  Asp Arg Cys 
    1025                 1030                 1035             


Arg Ile  Lys Ile Phe Asp Trp  Ala Phe Ala Leu Glu  Gly Ala Ile 
    1040                 1045                 1050             


Met Ser  Asp Arg Asp Leu Lys  Pro Tyr Leu His Glu  Ser Ser Ser 
    1055                 1060                 1065             


Arg Glu  Gly Lys Ser Gly Glu  His Ser Thr Leu Val  Lys Met Leu 
    1070                 1075                 1080             


Val Glu  Lys Lys Gly Cys Leu  Thr Pro Asp Glu Ser  Gln Tyr Leu 
    1085                 1090                 1095             


Ile Leu  Ile Arg Asn Lys Ala  Ala His Asn Gln Phe  Pro Cys Ala 
    1100                 1105                 1110             


Ala Glu  Met Pro Leu Ile Tyr  Arg Asp Val Ser Ala  Lys Val Gly 
    1115                 1120                 1125             


Ser Ile  Glu Gly Ser Ser Ala  Lys Asp Leu Pro Glu  Gly Ser Ser 
    1130                 1135                 1140             


Leu Val  Asp Ser Leu Trp Lys  Lys Tyr Glu Met Ile  Ile Arg Lys 
    1145                 1150                 1155             


Ile Leu  Pro Ile Leu Asp Pro  Glu Asn Arg Phe Phe  Gly Lys Leu 
    1160                 1165                 1170             


Leu Asn  Asn Met Ser Gln Pro  Ile Asn Asp Leu 
    1175                 1180                 


<210>  1469
<211>  1129
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1469

Met Glu Thr Asn Gln Gln Thr His Glu Asn Arg Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Asn Asn His Val Ala Thr Asp Phe Lys Arg Lys Pro 
        35                  40                  45              


Leu Pro Glu Glu Gly His Ile Pro Asp Ala Leu Leu Cys Asn Lys Thr 
    50                  55                  60                  


Ile Lys Asn Leu Asn Trp Asn His Val His Thr Arg Ala Leu Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ser Glu Ser Leu Pro Lys Asp Glu 
                85                  90                  95      


Arg Glu Asn Ser Asp Thr Glu Gly Lys Asp Phe Thr Ser Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Ser Glu Leu Gln Asp Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Asp Ser Arg Lys Leu Ile Val 
    130                 135                 140                 


Ser Pro Glu Leu Ala Asn Phe Leu Thr Val Asn Phe Gln Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Ala Arg Met Lys Asp Val Leu Thr Asp Thr Asp Tyr 
                165                 170                 175     


Ala Leu Val Glu Asn Leu Gln Met Val Ala Pro Asp Asn Lys Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ala Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Thr Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asn Leu Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Ser 
            260                 265                 270         


Val Ile Thr Asp Lys Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Asp Asp Glu Arg 
    290                 295                 300                 


Glu Thr Ile Leu Asp Glu Ile Asp Tyr Gln Asp Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg Tyr Ser Asp Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Asp Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Asn Tyr Thr Lys Gln Phe Ala Gly Glu 
        355                 360                 365             


Gln Ala Glu Arg Lys Val Leu Glu Asn Ala Asn Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asp Pro Glu Leu Ile Gln Gln Arg Ile Asp Lys Gln 
385                 390                 395                 400 


Gln His Thr Ala Gly Phe Asp Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Thr Lys Glu Asn Ile Ala Thr Leu Ile 
            420                 425                 430         


Ala Lys Ser Lys Ala Ser Ser Lys Val Glu His Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Gln Ala Glu Glu Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Ile Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Ser Gln Leu Pro Ala Asn Trp Asp Glu Phe Ser Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asp Ser Thr Leu Lys Tyr Leu 
        515                 520                 525             


Arg Gln Arg Lys Thr Thr Leu Asn Thr Ile Leu Ser Lys Ser Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Lys Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Thr Arg Leu Lys Ala Val Glu Lys His Lys Leu 
            580                 585                 590         


Asn Lys Ser Val Lys Ile Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Glu Glu Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Ala Asn Ala Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Phe Glu Asn Gly Gly His Pro Phe Leu Gln Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Gln Ala Tyr Leu Val 
        675                 680                 685             


Glu Lys Gly Asn Lys Met Val Pro Arg Leu Asn Pro Lys Thr Asn Lys 
    690                 695                 700                 


Thr Ser Lys Val Asp Glu Ser Trp Met Met Lys Gln Phe Tyr Val Lys 
705                 710                 715                 720 


Glu Trp Lys Glu Glu Ile Ala Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Ser Arg Ile Pro Phe Thr Ile Arg Gln Trp Asp Glu Lys 
            740                 745                 750         


Glu Lys Tyr Asp Leu Asn Val Trp Leu Gln His Val Thr Val Gly Lys 
        755                 760                 765             


Asn Lys Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe Asp 
    770                 775                 780                 


Glu Ala Leu Cys Asn Leu Leu Arg Glu Gln Leu Asp Thr Lys Ile Val 
785                 790                 795                 800 


Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Ile Trp Trp 
                805                 810                 815     


Lys Thr Arg Asn Asp Asp Thr Gln Gln Phe Tyr Gln Ser Glu Arg Glu 
            820                 825                 830         


Tyr Asp Ile Tyr Asn Glu Lys Val Arg Phe Lys Ile Asp Ser Ser Thr 
        835                 840                 845             


His Phe Ala Asp Tyr Tyr Lys Asn Ala Leu Ser Arg Ala Tyr Thr Arg 
    850                 855                 860                 


Leu Lys Ala Glu Arg Glu Thr Ala Arg Gln Thr Asn Lys Arg Leu Pro 
865                 870                 875                 880 


Pro Leu Glu Tyr Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile Ala 
                885                 890                 895     


Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met Ala 
            900                 905                 910         


Val Leu Met Leu Glu Gln Leu Met Asp Asn Ser Pro Asn Leu Arg Leu 
        915                 920                 925             


Ser Lys Ile Glu Thr Leu Leu Asn Asp Thr Thr Pro Ile Ser Glu Lys 
    930                 935                 940                 


Ile Ser Ala Lys Leu Ser Phe Asp Ala Ser Gly Glu Arg Ile Thr Asp 
945                 950                 955                 960 


Lys Ser Asn Pro Thr Ala Thr Lys Thr Leu Val Ala Glu Arg Lys Gln 
                965                 970                 975     


Lys Asn Tyr Thr Glu Leu Gln Lys Tyr Arg Tyr Asp Arg Arg Leu Pro 
            980                 985                 990         


Glu Leu Phe Glu Tyr Val Gln Ala  Asp Glu Ile Pro Leu  Glu Trp Leu 
        995                 1000                 1005             


Leu Asp  Glu Leu Ser Ala Tyr  Asn Ser Ala Lys Gln  Gln Val Phe 
    1010                 1015                 1020             


Asp Thr  Val Phe Ala Leu Glu  Lys Lys Ile Ile Gln  Thr Glu Pro 
    1025                 1030                 1035             


Asp Glu  Leu Lys Ser Leu Phe  Thr Gly Ala Asn Gly  Glu Leu Gln 
    1040                 1045                 1050             


Thr Gly  Asn Ile Gln His Lys  Pro Tyr Val Gln Trp  Leu Thr Asn 
    1055                 1060                 1065             


Lys Gly  Leu Ile Asn Lys Glu  Glu Lys Gln Phe Ile  Asn Met Val 
    1070                 1075                 1080             


Arg Lys  Cys Phe Ser His Asn  Gln Phe Pro Gln Arg  Thr Thr Met 
    1085                 1090                 1095             


Glu Leu  Leu Ile Pro Ala Trp  Asn Glu Lys Lys Leu  Ala Leu Gln 
    1100                 1105                 1110             


Ile Ala  Thr Val Tyr Asn Gln  Leu Ile Ala Asp Leu  Thr Asp Lys 
    1115                 1120                 1125             


Ile 
    


<210>  1470
<211>  1094
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1470

Met Glu Ala Asn Glu Gln Asn Gln Glu Asn Arg Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Asn Asn His Ile Ala Ala Asp Phe Gly Gln Ala Val 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ser Gly Phe Leu Cys Asn Lys Glu 
    50                  55                  60                  


Ile Lys Lys Leu Asn Trp Asn His Ile Tyr Ala Lys Thr Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ile Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Val Asn Ser Asp Lys Glu Gly Lys Asp Phe Ala Ala Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Ser Glu Leu Gln Asp Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Glu Asn Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Ala Glu Leu Thr Asp Met Leu Thr Ile Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Thr Asp Ala Asp Tyr 
                165                 170                 175     


Glu Leu Val Glu Thr Lys Gln Val Val Thr Thr Gly Asn Ile Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Met Phe Leu Glu Arg Glu His 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asn Leu Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Gly 
            260                 265                 270         


Val Ile Thr Asp Glu Glu Lys Met Gln Phe Arg Pro Glu Leu Asp Glu 
        275                 280                 285             


Leu Asp Ile Glu Lys Leu Ile Ala Asn Ser Thr Asn Asp Asp Glu Arg 
    290                 295                 300                 


Glu Arg Ile Leu Asp Glu Ile Gly Tyr Glu Glu Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg Tyr Asn Asn Arg Phe Pro Tyr Phe Ala Met Arg 
                325                 330                 335     


Phe Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Arg Tyr Thr Lys Gln Leu Ala Gly Glu 
        355                 360                 365             


Gln Thr Glu Arg Val Val Gln Glu Asn Val Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asp Pro Glu Leu Ile Gln Gln Lys Ile Asp Asn Gln 
385                 390                 395                 400 


Gln Arg Thr Asp Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Ile Ala Ile Leu Ile 
            420                 425                 430         


Pro Lys Ser Lys Pro Glu Ser Lys Val Gly Asn Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Asp Tyr Leu Gln Lys Gly Lys Ala Glu Glu Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Ile Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Leu Lys Leu Pro Ala Asn Trp Asn Glu Phe Ala Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asp Ala Ala Met Glu Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Asp Val Leu Ile Thr Tyr Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Asp Val Glu Asp Asn Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Leu Glu Lys His Lys Leu 
            580                 585                 590         


Asp Lys Ser Val Lys Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Met Val Ser Lys Glu Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Ala Asp Thr Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Val Leu Glu Gly Asp Gly His Pro Phe Leu Thr Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Glu Leu Tyr Met Asn 
        675                 680                 685             


Ala Lys Val Gln Tyr Leu Ile Gln Phe Tyr Lys Pro Ser Lys Asp Lys 
    690                 695                 700                 


Val Asp Lys Arg Gly Arg Pro Thr Thr Glu Val Lys Leu Pro Pro Leu 
705                 710                 715                 720 


Asp Lys Arg Ser Asn Ile Pro Phe Thr Ile Arg Gln Trp Asp Glu Lys 
                725                 730                 735     


Glu Lys Tyr Asn Leu Asn Ala Trp Leu Arg Asn Val Thr Val Gly Lys 
            740                 745                 750         


Asn Thr Lys Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe 
        755                 760                 765             


Asp Glu Thr Leu Cys Asp Leu Leu Ser Gln Gln Leu Asp Ala Arg Thr 
    770                 775                 780                 


Val Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Leu Trp 
785                 790                 795                 800 


Trp Lys Thr Arg Asp Asp Ala Thr Gln Asp Phe Tyr Gln Ser Glu Arg 
                805                 810                 815     


Glu Tyr Asp Ile Tyr Glu Glu Lys Val Glu Phe Lys Ile Asp Ser Ser 
            820                 825                 830         


Gly His Phe Ala Asp Tyr Tyr Lys Lys Ala Leu Ser Lys Ala Tyr Asn 
        835                 840                 845             


Arg Leu Lys Ala Glu Arg Glu Ile Ala Arg Arg Thr Asn Lys Arg Leu 
    850                 855                 860                 


Pro Pro Ile Glu His Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile 
865                 870                 875                 880 


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
                885                 890                 895     


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asp Ser Gly Asn Leu Lys 
            900                 905                 910         


Leu Ser Thr Ile Lys Thr Ser Leu Asn Asn Thr Thr Gln Ile Lys Gln 
        915                 920                 925             


Lys Ile Leu Asn Lys Thr Ile Val Ala Glu Arg Lys Gln Lys Asn Tyr 
    930                 935                 940                 


Thr Glu Leu Arg Lys Tyr Val His Asp Arg Arg Leu Pro Asn Leu Phe 
945                 950                 955                 960 


Glu Tyr Val Glu Ala Asp Glu Ile Leu Leu Glu Trp Leu Leu Asp Glu 
                965                 970                 975     


Leu Met Ala Tyr Asn Ala Ala Lys Gln Gln Val Phe Asp Thr Ile Phe 
            980                 985                 990         


Met Leu Glu Lys Arg Ile Ile Glu  Thr Asp Pro Gln Glu  Leu Lys Ser 
        995                 1000                 1005             


Leu Phe  Thr Asn Glu Lys Gly  Gln Val Gln Thr Gly  Asn Ile Gln 
    1010                 1015                 1020             


His Lys  Pro Tyr Val Gln Trp  Leu Lys Asn Lys Gly  Leu Ile Asn 
    1025                 1030                 1035             


His Asn  Glu Lys Leu Phe Ile  Asn Met Val Arg Asn  Cys Phe Ser 
    1040                 1045                 1050             


His Asn  Gln Phe Pro Gln Arg  Glu Thr Met Glu Leu  Leu Ile Ser 
    1055                 1060                 1065             


Glu Trp  Gly Ala Gly Lys Ile  Ala Thr Gln Ile Leu  Thr Val Tyr 
    1070                 1075                 1080             


Asn Gln  Leu Ile Thr Asn Ile  Ile Asn Lys Ile 
    1085                 1090                 


<210>  1471
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1471

Met Glu Thr Lys Gln Gln Val Gly Lys Gly Ile Ser Tyr Asp His Arg 
1               5                   10                  15      


Arg Pro Asp Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asp Gly Val Ile Gln Glu Phe Ala Met Arg Leu Asn Arg 
        35                  40                  45              


Glu Tyr Asp Pro Glu Asn Lys Asn Gln Ser Leu Phe Ser Tyr Phe Asn 
    50                  55                  60                  


Ile Asn Ala Ser Phe Thr Asp Trp Glu Arg Gly Val Asn Ile Leu Lys 
65                  70                  75                  80  


Glu Tyr Trp Pro Met Met Glu Phe Ile Asp Arg Pro Ala Thr Asp Lys 
                85                  90                  95      


Gln Phe Glu Ala Glu Lys Pro Glu Asn Arg Glu Ala Ala Lys Arg Lys 
            100                 105                 110         


Tyr Phe Leu Ala Thr Leu Gly Ala Leu Leu Thr Ser Ile Lys Asp Leu 
        115                 120                 125             


Arg His Tyr Tyr Thr His Tyr Tyr His Pro Pro Val His Leu Asn Asp 
    130                 135                 140                 


Asp Leu Phe Leu Phe Leu Asp His Ala Leu Leu Tyr Thr Ala Phe Asp 
145                 150                 155                 160 


Val Lys Lys Thr Lys Met Lys Asp Asp Lys Thr Arg Gln Leu Leu Asn 
                165                 170                 175     


Gln Asn Leu Ser Leu Glu Leu Glu Lys Leu Lys Lys Leu Lys Val Glu 
            180                 185                 190         


Glu Leu Lys Lys Lys Lys Glu Lys Gly Ile Lys Val Asn Leu Gln Asp 
        195                 200                 205             


Glu Lys Gly Ile Leu Asn Ala Ile Tyr Asn Asp Ala Phe Ala His Ile 
    210                 215                 220                 


Ile Thr Lys Glu Lys Asp Ser Asp Lys Asp Lys Leu Glu Thr Arg Tyr 
225                 230                 235                 240 


Lys Ser Ile Leu Pro Gln Asp Glu Ala Ala Glu Thr Gly Ile Asn Ile 
                245                 250                 255     


Ser Ile Ser Gly Leu Ile Phe Leu Leu Ser Leu Phe Leu Ser Arg Lys 
            260                 265                 270         


Glu Ile Glu Gln Leu Lys Ser Asn Ile Glu Gly Tyr Lys Gly Lys Val 
        275                 280                 285             


Leu Asn Ile Glu Thr Glu Val Asp Arg Lys His Asn Ser Leu Lys Tyr 
    290                 295                 300                 


Met Ala Thr His Trp Val Phe Ser Ile Leu Ala Phe Lys Gly Leu Lys 
305                 310                 315                 320 


Gln Arg Leu Thr Asn Ser Phe Glu Lys Glu Ser Leu Leu Ile Gln Met 
                325                 330                 335     


Met Asp Glu Leu Asn Lys Val Pro Asp Glu Leu Tyr Gln Thr Leu Ser 
            340                 345                 350         


Glu Thr Ala Lys Lys Glu Phe Leu Glu Asp Ile Asn Glu Tyr Val Ser 
        355                 360                 365             


Glu Gly Asp Asp Asn Glu Lys Ala Thr Tyr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Ser Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gln Phe Pro Thr Leu Lys Phe Gln Ile Phe Val Gly 
                405                 410                 415     


Gln Tyr Leu His Asp Asn Arg Pro Lys Thr Leu Ala Ser Asn Gly Met 
            420                 425                 430         


Thr Ala Gln Arg Met Ile Lys Glu Lys Ile Asn Leu Phe Gly Asn Leu 
        435                 440                 445             


Ser Glu Val Thr Lys His Lys Ser Asp Phe Phe Glu Lys Glu Ser Ala 
    450                 455                 460                 


Ala Gln Gly Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Trp Ala Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Val Tyr Ile Asp Met Ile Gly Lys Glu Gly Lys Ala 
                485                 490                 495     


Lys Glu Ile Gln Val Gln Ile Asn Lys Tyr Arg Lys Gln Leu Asn Pro 
            500                 505                 510         


Ala Pro Gln Arg Asp Lys Arg Ile Ser Lys Lys Glu Ile Ile Glu Gln 
        515                 520                 525             


Leu Tyr Lys Glu Lys Val Val Tyr Gly Asp Pro Thr Leu Met Leu Ser 
    530                 535                 540                 


Ala Asn Glu Leu Met Ala Leu Leu Tyr Glu Leu Ile Val Asn Gly Lys 
545                 550                 555                 560 


Ser Gly Ala Glu Leu Glu Asn Lys Ile Val Glu Gln Ile Ile Ala Arg 
                565                 570                 575     


Tyr Glu Gln Ile Glu Ala Tyr Asp Pro Thr Thr Gln Gln Leu Pro Thr 
            580                 585                 590         


Asn Gln Met Pro His Lys Leu Gln Lys Ser Arg Lys Asp Ser Lys Val 
        595                 600                 605             


Thr Asp Thr Asp Lys Leu Leu Lys Thr Ile Asp Lys Glu Ile Asp Glu 
    610                 615                 620                 


Gly Asn Lys Lys Leu Glu Leu Ile Ala Cys His Arg Lys Glu Trp Glu 
625                 630                 635                 640 


Glu Ala Glu Gln Arg Lys Lys Ser Gly Lys Arg Asn Asn Pro Gly Thr 
                645                 650                 655     


Lys Ser Arg Lys His Leu Phe Tyr Ala Ser Glu Met Gly Glu Glu Ala 
            660                 665                 670         


Thr Trp Ile Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Pro Ala Arg 
        675                 680                 685             


Ala Glu Trp Lys Gly Thr His His Ser Glu Leu Gln Arg Leu Leu Ala 
    690                 695                 700                 


Phe Tyr Ser Thr Gln Arg Leu Glu Ala Trp Gln Leu Val Glu Ser Val 
705                 710                 715                 720 


Trp Thr Ala Asn Thr His Ser Phe Trp Glu Glu Asn Phe Lys Glu Ala 
                725                 730                 735     


Phe Tyr Lys Pro Glu Phe Glu Asn Phe Tyr Gly Ala Tyr Ile Glu Ile 
            740                 745                 750         


Arg Thr Lys Ile Leu Thr Thr Cys Arg Ser Ile Leu Glu Asn Asn Pro 
        755                 760                 765             


Glu Ala Thr Met Asn Asn Asp Thr Glu Lys Glu Trp Asp Lys Val Phe 
    770                 775                 780                 


Thr Leu Phe Asp Lys Arg Leu Tyr Arg Thr Ser Thr Thr Asp Glu Gln 
785                 790                 795                 800 


Lys Lys Gln Leu Leu Thr Lys Pro Phe Ala Phe Pro Arg Gly Leu Phe 
                805                 810                 815     


Asp Asp Lys Pro Thr Phe Leu Pro Gly Ser Lys Pro Asn Glu Asn Pro 
            820                 825                 830         


Glu Arg Phe Ala Ala Trp Tyr Ser Tyr Gly Tyr Thr Tyr Ser Gly Lys 
        835                 840                 845             


Phe Gln Ser Phe Tyr Asp Met Pro Arg Asn Tyr Ser Asp Trp Tyr Lys 
    850                 855                 860                 


Lys Leu Lys Glu Asp Gly Lys Leu Pro Arg Leu Asp Lys Lys Thr Glu 
865                 870                 875                 880 


Gln Glu Lys Ile Leu Arg Phe Arg Met Asp Cys Asp Leu Asn Ile Lys 
                885                 890                 895     


His Ile Arg Phe Gln Asp Ile Tyr Val Lys Leu Met Val Asp Ser Leu 
            900                 905                 910         


Tyr Lys Ala Val Phe Gly Gln Gln Pro Glu Phe Asp Leu Ser His Leu 
        915                 920                 925             


Tyr Asp Thr Arg Ser Glu Arg Tyr Glu Asn Asn Thr Ile Ala Gln Arg 
    930                 935                 940                 


Gln Lys Ser Arg Gln Glu Gly Asp Asn Ser Asp Asn Ala Ile Asn Glu 
945                 950                 955                 960 


Asn Tyr Val Trp Asn Lys Thr Phe Ala Ile Ser Leu Tyr Asn Gly Arg 
                965                 970                 975     


Ile Thr Glu Ser Gln Val Lys Leu Lys Asp Val Gly Lys Phe Arg Arg 
            980                 985                 990         


Phe Ala Thr Asp Pro Arg Val Gln  Thr Leu Ile Ser Tyr  Asp Asp Thr 
        995                 1000                 1005             


Arg Thr  Trp Thr Lys Leu Glu  Ile Glu Asn Glu Leu  Asp Asn Lys 
    1010                 1015                 1020             


Ala Asp  Ala Tyr Glu Pro Ile  Arg Arg Thr Gln Ser  Leu Lys Ala 
    1025                 1030                 1035             


Ile Gln  Gln Leu Glu Lys Asn  Ile Leu Lys Lys Asn  Gly Phe Asn 
    1040                 1045                 1050             


Gly Lys  Gln His Pro Glu Glu  Leu Lys His Asn Gly  Asn Pro Asn 
    1055                 1060                 1065             


Phe Arg  Lys Tyr Ile Ala Asn  Gly Leu Leu Lys His  Arg Thr Asp 
    1070                 1075                 1080             


Ile Arg  Gln Glu Glu Leu Ala  Leu Ile Ser Asp Thr  Glu Phe Gln 
    1085                 1090                 1095             


Glu Ile  Gly Leu Glu Arg Ile  Arg Gln Thr Asn Pro  Leu Ile Gln 
    1100                 1105                 1110             


Lys Ala  Tyr Leu Leu Ile Leu  Leu Arg Asn Lys Phe  Gly His Asn 
    1115                 1120                 1125             


Gln Leu  Pro Asp Gln Glu His  Phe Arg Leu Met Arg  Ser Ile Tyr 
    1130                 1135                 1140             


Pro Tyr  Asn Gln Gln Glu Ser  Tyr Ser Ala Tyr Phe  Asn His Val 
    1145                 1150                 1155             


Ile Thr  Gln Ile Ile Glu Glu  Leu Asn Thr 
    1160                 1165             


<210>  1472
<211>  1057
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1472

Met Thr Ile Lys Glu Gln Ser His Phe Ala Ala Tyr Tyr Asn Met Ala 
1               5                   10                  15      


Arg His Asn Met Tyr Glu Thr Leu Cys Tyr Ile Ser Lys Ile Ser Gly 
            20                  25                  30          


Ile Gln Glu Gly Glu Asp Asn Lys Glu Ser Lys Ile Glu Asp Met Gln 
        35                  40                  45              


Leu Leu Arg Val Leu Thr Thr Lys Gly His Pro Glu Glu Lys Ile Arg 
    50                  55                  60                  


Ile Glu Lys Leu Ile Tyr Lys His Leu Pro Leu Phe Arg Pro Ala Val 
65                  70                  75                  80  


Glu Asp Leu Arg Lys Lys Ser Lys Glu Asn Val Lys Ser Pro Glu Leu 
                85                  90                  95      


Leu Ala Lys Val Ile Lys Asn Trp Ala Lys Val Ile Thr Tyr Tyr Arg 
            100                 105                 110         


Asp Lys Phe Thr His Tyr Val Phe Ile Asp Lys Arg His Glu Asn Lys 
        115                 120                 125             


Glu Phe Leu Asn Ala Glu Met Ser Val Ala Asn Asp Leu Asn Gln Ile 
    130                 135                 140                 


Phe Thr Ala Ser Ala Arg Val Ile Lys Glu Arg Phe Gly Leu Ser Thr 
145                 150                 155                 160 


Glu Leu Glu Phe Leu Thr Lys Gly Arg Tyr Arg Thr Gln Thr Ile Asp 
                165                 170                 175     


Gly Lys Arg Ser Thr Lys Leu Asn Pro Asn Phe Ile Tyr Ser Leu Gln 
            180                 185                 190         


Asp Lys Asn Glu Arg Leu Asn Lys Met Gly Leu Ile Phe Leu Ala Cys 
        195                 200                 205             


Gln Leu Ile Glu Lys Lys Tyr Ala Ser Met Leu Phe Asp Gln Gln Gly 
    210                 215                 220                 


Tyr Met Gly Arg Asp Ile Tyr Phe Asp Phe Thr Pro Ala Gln Cys Lys 
225                 230                 235                 240 


Tyr Ile Arg Glu Val Phe Ser Ala His Arg Ile Val Leu Pro Arg Gly 
                245                 250                 255     


Arg Met Asp Val Glu Arg Asn Glu Ile Thr Ile Ala Met Asp Met Phe 
            260                 265                 270         


Asn Glu Leu Gly Lys Cys Pro Lys Glu Leu Phe Glu Ile Ile Ser Lys 
        275                 280                 285             


Glu Glu Gln Lys Arg Phe Arg Thr Lys Ser Glu Thr Thr Gly Glu Glu 
    290                 295                 300                 


Val Leu Leu Met Arg His Ser Asp Arg Phe Ala Thr Leu Ala Leu Gln 
305                 310                 315                 320 


Tyr Ile Asp Asn Arg Lys Val Phe Glu Lys Ile Arg Phe Gln Leu Ser 
                325                 330                 335     


Leu Gly Lys Tyr Arg Tyr Lys Phe Tyr Asp Lys Thr Cys Val Asp Gly 
            340                 345                 350         


Asp Thr His Val Arg Ile Leu Gln Lys Glu Leu Asn Gly Phe Gly Arg 
        355                 360                 365             


Ile Asn Glu Ile Glu Leu Leu Lys Glu Glu Lys Trp Gly Gly Leu Ile 
    370                 375                 380                 


Arg Lys Phe Glu Asp Ala Lys Ile Asp Thr Ala Glu Thr Lys Pro Tyr 
385                 390                 395                 400 


Ile Thr Asp Gln Tyr Pro Gln Tyr Leu Phe Asn Gly Asn Arg Ile Gly 
                405                 410                 415     


Ile Tyr Phe Asn Ser Ala His Gly Lys Ala Met Arg Asn Gly Ala Tyr 
            420                 425                 430         


Ile Pro Asp Ile Glu Ser Gly Ala His Cys Ile Gln Pro Ile Cys Trp 
        435                 440                 445             


Ile Ser Asn Tyr Glu Leu Pro Ala Leu Ile Phe His His Ile Leu Thr 
    450                 455                 460                 


Lys Asp Glu Lys Lys Ser Leu Thr Glu Lys Ile Ile Ile Asp Cys Val 
465                 470                 475                 480 


Glu Arg Tyr Lys Lys Leu Phe Asn Asp Ile Ala Glu Gly Lys Val Ala 
                485                 490                 495     


Arg Thr Gly Asn Ala Thr Ser Asp Phe Glu Met Ile Ser Lys Glu Tyr 
            500                 505                 510         


Gly Ile Glu Lys Ser Asp Ile Pro Arg Glu Leu Gln Asp Tyr Phe Asn 
        515                 520                 525             


Gly Thr Glu Arg Asp Gly Ile Glu Gln Tyr Ala Lys Ala Gln Ile Arg 
    530                 535                 540                 


Glu Met Ile Glu Glu Asn Arg Ile Arg Leu Glu Gln Phe Asn Ser Lys 
545                 550                 555                 560 


Leu Lys Lys Ile Glu Asp Gly Glu Val Lys Tyr Gly Lys Arg Asp Tyr 
                565                 570                 575     


Thr Glu Ile Arg Thr Gly Glu Leu Ala Gln Tyr Leu Ala Lys Asp Ile 
            580                 585                 590         


Val Met Phe Met Pro Lys Ala Lys Tyr Lys Pro Thr Ser Lys Asn Tyr 
        595                 600                 605             


Asn Val Met Gln Ala Leu Leu Ala Thr Phe Asn Gly Ser Glu Ser Gly 
    610                 615                 620                 


Ser Thr Leu Asp Glu Val Asp Asp Met Phe Asp Asn Ile Lys Ala Cys 
625                 630                 635                 640 


Tyr Trp Lys Asn Glu Ser Asp Asn His Pro Phe Leu Glu Tyr Val Leu 
                645                 650                 655     


Gly Glu Glu Pro Lys Asp Ile Ile Ala Phe Tyr Lys Ile Tyr Leu Glu 
            660                 665                 670         


Leu Arg Gly Glu Tyr Leu Asp Lys Cys Ile Lys Lys Met Asp Leu Ala 
        675                 680                 685             


Thr Ile Pro Phe Ile His Thr Glu Arg Lys Arg Trp Glu Lys Arg Asp 
    690                 695                 700                 


Glu Lys Phe Phe Lys Glu Leu Ala Gln Arg Tyr Ala Thr Gln Pro Ile 
705                 710                 715                 720 


Glu Leu Pro Arg Gly Leu Tyr Asp Arg Ala Ile Lys Glu Tyr Leu Lys 
                725                 730                 735     


Ser Lys Ser Ile Leu Glu Asp Val Ile Ala Gln Glu Gln Cys Asn Val 
            740                 745                 750         


Thr Tyr Leu Ile Ala Arg Tyr Met Gln Asp Val Leu Lys Asp Asp Ser 
        755                 760                 765             


Gln Gln Phe Tyr Ser Leu Pro Arg His Tyr Ser Cys Leu Ser Glu Lys 
    770                 775                 780                 


Asp Lys Tyr Leu Ser Leu Thr Glu Arg Glu Ala Ile Ala Lys Ser Asp 
785                 790                 795                 800 


Ala Leu Asn Ser Phe Lys Lys Arg Glu Arg Glu Lys Glu Asn Glu Asn 
                805                 810                 815     


Arg Arg Gly Asn Arg Arg Tyr Asn Lys Gly Glu Asn Lys Asn Thr Ile 
            820                 825                 830         


Lys Asp Arg Asp Thr Glu Glu Lys Phe Asn Ser Leu Tyr Arg Lys Met 
        835                 840                 845             


Asp Asn Asn Glu Arg Ile Leu Arg Arg Tyr Lys Val Gln Asp Met Leu 
    850                 855                 860                 


Leu Tyr Leu Leu Ala Cys Asp Ile Ile Lys Gly Ile Met Arg Glu Asp 
865                 870                 875                 880 


Phe Gly Tyr Lys Leu Ser Met Ile Thr Asp Gly Lys Asn Ser Asn Phe 
                885                 890                 895     


Phe Asp Tyr Lys Met Pro Glu Phe Lys Thr Thr Ile Thr Leu Lys Glu 
            900                 905                 910         


Gly Lys Lys Phe Thr Ile Lys Gln Gln Tyr Leu Lys Ile Lys Asn Tyr 
        915                 920                 925             


Gly Asp Phe Leu Lys Phe Ile Phe Asp Leu Arg Ile Asp Ser Leu Leu 
    930                 935                 940                 


Ser Asn Gly Thr Lys Val Glu Ile Asp Arg Asn Ile Leu Glu Asp Glu 
945                 950                 955                 960 


Leu Ser Asn Tyr Asp Gly Ser Arg Pro Lys Val Phe Glu Thr Leu Leu 
                965                 970                 975     


Met Ile Glu Lys Ile Val Val Glu Lys His Lys Glu Leu Lys Asp Leu 
            980                 985                 990         


Glu His Ile Thr Phe Gly Asp Val  Leu Asn Val Ile Lys  Met Glu Glu 
        995                 1000                 1005             


Gly Glu  Lys Lys Ile Leu Arg  Leu Ile Arg Asn Ala  Phe Ser His 
    1010                 1015                 1020             


Asn Tyr  Tyr Pro Thr Ile Lys  Asp Val Asn Tyr Asp  Asn Met Pro 
    1025                 1030                 1035             


Glu Val  Ala Glu Ser Leu Lys  Asp Ile Leu Glu Lys  Glu Ser Lys 
    1040                 1045                 1050             


Lys Leu  Thr Asn 
    1055         


<210>  1473
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1473

Met Asn Thr His Gln Glu Glu Leu Gln Ser Trp Ile Thr Arg Lys Arg 
1               5                   10                  15      


Leu Pro Asp Thr Glu Met Lys Lys Tyr Trp Ala Ala Tyr Met Asn Leu 
            20                  25                  30          


Ala Arg Leu Asn Phe Phe Lys Thr Leu Met Phe Ile Ser Asn Ser Ile 
        35                  40                  45              


Gly Asp Leu Lys Pro Ala Lys Asp Asn Asn Gly Lys Gly Asn Thr Glu 
    50                  55                  60                  


Val Asn Met His Asn Met Gly Ile Leu Thr Ala Leu Leu Gly Pro Glu 
65                  70                  75                  80  


Asp Glu Glu Lys Ala Arg Leu Leu Ile Phe Lys His Phe Pro Phe Leu 
                85                  90                  95      


Arg Thr Phe Cys Ile Glu Lys Glu Leu Ser Leu Ser Lys Gln Arg Thr 
            100                 105                 110         


Ile Leu Ile Asp Met Ala Cys Ile Ile Gly Arg Tyr Arg Asn Met Tyr 
        115                 120                 125             


Ser His Ser Ile Phe Ile Ser Asp Asp Asn Glu Lys Val Leu Glu Ser 
    130                 135                 140                 


Glu Lys Arg Cys Ser Glu Tyr Leu Gln Ser Ile Leu Thr Val Ser Thr 
145                 150                 155                 160 


Arg Ile Ile Lys Glu Arg Tyr Arg Ser Asn Lys Asn Asp Ala Gln Arg 
                165                 170                 175     


Gly Met Ile Asp Asp Lys Ser Leu Lys Phe Ile Ser Glu Asn Lys Val 
            180                 185                 190         


Lys Phe Val Tyr Asp Glu Asn Gly Lys Arg Ile Thr Ala Pro Asn Lys 
        195                 200                 205             


Lys Tyr Tyr Leu Ser Thr Ile Asp Lys Asp Asn Thr His Leu Ser Tyr 
    210                 215                 220                 


Phe Gly Lys Leu Met Leu Thr Cys Ile Leu Leu Glu Lys Lys Tyr Ala 
225                 230                 235                 240 


Thr Asp Phe Leu Thr Gln Cys His Phe Leu Asp Ala Phe Asn Asp Ser 
                245                 250                 255     


Glu Val Ala Pro Lys Leu Ser Glu Arg Arg Leu Met Leu Glu Val Met 
            260                 265                 270         


Thr Ala Leu Arg Ile Arg Leu Ala Glu Lys Lys Leu Ser Asn Glu Lys 
        275                 280                 285             


Ser Glu Val Gln Ile Ser Leu Asp Ile Leu Asn Glu Leu Lys Lys Cys 
    290                 295                 300                 


Pro Phe Glu Leu Tyr Glu Leu Leu Gly Ser Glu Asp Lys Arg Leu Phe 
305                 310                 315                 320 


Thr Ile Val Ala Asp Thr Gly Glu Thr Ile Leu Leu Arg Arg His Glu 
                325                 330                 335     


Asp Arg Phe Pro Gln Leu Ala Leu Ser Trp Ile Asp Ser Ser Lys Ala 
            340                 345                 350         


Phe Asp His Leu Arg Phe Gln Val Asn Ala Gly Lys Leu Arg Tyr Leu 
        355                 360                 365             


Phe Arg Asp Asn Lys His Cys Ile Asp Gly Gln Thr Arg Met Arg Val 
    370                 375                 380                 


Leu Glu Glu Pro Leu Asn Gly Tyr Arg Arg Leu Met Glu Phe Glu Glu 
385                 390                 395                 400 


Glu Arg Ile Gln Lys Gln Ser Gly Glu Ile Arg Ser Leu Trp Pro Gly 
                405                 410                 415     


Leu Asp Ile Leu Asn Lys Asp Glu Thr Pro Arg Asn Asp Ala Ser Val 
            420                 425                 430         


Leu Pro Tyr Ile Ser Asp Tyr Arg Val Arg Tyr Leu Phe Asp Gly Asp 
        435                 440                 445             


Asn Ile Gly Ile Ser Ile Gly Asp Phe Thr Pro Ser Ile Thr Lys Thr 
    450                 455                 460                 


Asp Glu Thr Lys Tyr Arg Val Thr Gly Lys Thr Ala Asp Cys Cys Leu 
465                 470                 475                 480 


Ser Lys Tyr Glu Leu Pro Gly Leu Leu Phe Tyr His Leu Leu Thr Leu 
                485                 490                 495     


Arg His Gly Asp Asn Lys Arg Ser Thr Lys Asn Ala Glu Asp Ile Ile 
            500                 505                 510         


Ile Asp Ala Ile Lys Arg Tyr Lys Arg Leu Phe Ser Asp Val Lys Glu 
        515                 520                 525             


Gly Ile Leu Lys Pro Ile Lys Glu Gly Asn Ala Asn Gln Leu Gly Asn 
    530                 535                 540                 


Arg Ile Trp Asn Ser Tyr Gly Ile Asp Ile Lys Asp Ile Pro Asp Lys 
545                 550                 555                 560 


Ile Ile Asp Tyr Leu Leu Val Arg Glu Cys Asn Glu Asp Glu Lys Phe 
                565                 570                 575     


Thr Ala Trp Lys Asn Gly Leu Ile Ser Glu Met Leu Gln Ser Thr Lys 
            580                 585                 590         


Asn Arg Ile Lys Arg Phe Glu Lys Asp Ser Glu Ala Val Ile Ser Ser 
        595                 600                 605             


Asp Asn Lys Pro Gly Lys Lys Asn His Val Ser Leu Lys Pro Gly Ala 
    610                 615                 620                 


Tyr Ala Ser Phe Ile Ala Asn Asp Ile Met Phe Phe Gln Glu Cys Gly 
625                 630                 635                 640 


Ala Thr Glu Lys Met Thr Gly Leu Asn Phe Lys Val Met Gln Ser Arg 
                645                 650                 655     


Leu Ala Thr Phe Thr Lys Asp Gly Ser Thr Ser Phe Asn Ile Leu Leu 
            660                 665                 670         


Gln Thr Leu Lys Asn Ala His Leu Val Ser Thr Thr Tyr Gly Lys Gly 
        675                 680                 685             


Asp His Pro Phe Leu Tyr Arg Val Ile Lys Gln Gln Pro Ser Asp Ile 
    690                 695                 700                 


Val Gln Phe Tyr Lys Ile Tyr Leu Asn Glu Lys Val Leu Tyr Leu Gln 
705                 710                 715                 720 


Ser Asp Ile Pro Asp Asn Ala Ile Phe Leu His Gly Glu Arg Lys Arg 
                725                 730                 735     


Trp Glu Asn Arg Asn Glu Gln Tyr Tyr Arg Asp Leu Ala Glu Arg Tyr 
            740                 745                 750         


Leu Gln Arg Pro Ile Gln Leu Pro Arg Gln Leu Phe Glu Ser His Ile 
        755                 760                 765             


Arg Gln Leu Leu Leu Ser Asp Cys Ile Lys Gly Glu Arg Gly Asn Asp 
    770                 775                 780                 


Leu Lys Glu Ala Ile Asn Ser Ala Ala Ser Gln Gly Arg Cys Asn Thr 
785                 790                 795                 800 


Thr Tyr Met Ile Met Glu Tyr Phe Ala Asp Tyr Leu Cys Asp Gly Thr 
                805                 810                 815     


Gln Phe Phe Tyr Gly Leu Phe Asp Gly Asp Leu Ser His Glu Tyr Asn 
            820                 825                 830         


Tyr Arg Phe Tyr Ser Leu Ile Ser Asn Asn Ile Glu Asn Ser Lys Lys 
        835                 840                 845             


Leu Val Leu Thr Leu Lys Lys Gly Asn Asn Ser Lys Glu Ser Pro Phe 
    850                 855                 860                 


Ile Ser Ala Leu Glu Arg Gly Ile His Trp Ser Lys Arg Asn Pro Leu 
865                 870                 875                 880 


Met Lys Lys Gly Leu Lys Asn Asp Ser Ser Glu Gly Asp Phe Val His 
                885                 890                 895     


Ala Ala Lys Arg Ala Tyr Lys Glu Met Thr Glu Thr Glu Arg Met Phe 
            900                 905                 910         


Arg Arg Tyr Ala Val Gln Asp Glu Val Leu Phe Leu Ala Ala Lys Ile 
        915                 920                 925             


Thr Ile Arg Arg Ala Leu Gly Leu Ser Glu Gln Tyr Asn Cys Leu Leu 
    930                 935                 940                 


Gly Asp Ile Lys Pro Gln Gly Gly Ser Leu Leu Glu Gln Thr Ile Pro 
945                 950                 955                 960 


Ser Ile Thr Thr Lys His Thr Ile Asn Thr Gly Asn Lys Lys Gln Lys 
                965                 970                 975     


Pro Lys Gln Val Gln Ile Leu Gln Lys Asn Val Lys Leu Lys Asp Phe 
            980                 985                 990         


Gly Lys Val Phe Lys Leu Leu Asn  Asp Arg Arg Ile Phe  Asp Leu Leu 
        995                 1000                 1005             


Phe Asn  Lys Gly Asn Glu Ala  Val Ser Met Thr Asp  Leu Cys Glu 
    1010                 1015                 1020             


Glu Leu  Glu Arg Tyr Asp Arg  His Arg Val Asp Val  Phe Asp Ser 
    1025                 1030                 1035             


Val Leu  Lys Tyr Glu Ser Lys  Ile Thr Lys Gly Tyr  Thr Asn Lys 
    1040                 1045                 1050             


Glu Leu  Met Asn Glu Ser Gly  Gln Ile Asp Phe Lys  Ala Ile Gln 
    1055                 1060                 1065             


Ala Phe  Asp Lys Gln Asn Thr  Thr Ala Asp Lys Glu  Asp Leu Arg 
    1070                 1075                 1080             


Leu Ile  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Gln Tyr Asn 
    1085                 1090                 1095             


Asn Glu  Pro Ile Leu Phe Asp  Lys Asp Ile Pro Glu  Ile Ala Asp 
    1100                 1105                 1110             


Glu Ile  Ser Ile Ile Ala Lys  Asp Ile Glu Glu Asn  Thr Lys 
    1115                 1120                 1125         


<210>  1474
<211>  1047
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1474

Met Glu Glu Gln Phe Leu Gln Lys Glu Arg Asn Met Gly Asp Asn Pro 
1               5                   10                  15      


Tyr Tyr Phe Cys His Phe Ile Asn Met Ala His His Asn Val Asn Leu 
            20                  25                  30          


Ile Leu Glu Glu Ile Tyr Asn Ser Val Tyr Glu Lys Tyr Thr Gln Asp 
        35                  40                  45              


Lys Glu Glu Asn Ile Lys Ala Ile Cys Asn Ser Met Ile Ser Lys Ser 
    50                  55                  60                  


Arg Lys Asn Pro Asp Glu Lys Ala Lys Met Met Asn Met Cys Ile Arg 
65                  70                  75                  80  


His Phe Pro Phe Leu Asp Tyr Tyr Lys Glu Lys Asp Gln Asn Ser Asp 
                85                  90                  95      


Val Leu Thr Ile Leu Leu Asn Gln Phe Leu Val Pro Leu His Gly Leu 
            100                 105                 110         


Arg Asn Gln Phe Ser His Tyr Lys His Pro Gln Glu Ala Tyr Cys Ile 
        115                 120                 125             


Ser Gly Phe Asp Leu Leu Phe Glu Gln Ala Lys Thr Gly Ala Gln Met 
    130                 135                 140                 


Arg Met Lys Tyr Ser Asp Glu Asp Ile Ser Lys Val Lys Ser Lys Val 
145                 150                 155                 160 


Val Asn His Asp Ser Ile Leu Thr Glu Arg Gly Ile Leu Phe Phe Ile 
                165                 170                 175     


Cys Leu Phe Leu Asp Lys Arg Asn Ile Tyr Leu Phe Leu Ser Lys Ile 
            180                 185                 190         


Lys Gly Phe Arg Asp Arg Arg Pro Asp Glu Lys Tyr Lys Ser Ala Thr 
        195                 200                 205             


Leu Glu Val Phe Ser Gln Tyr Tyr Cys His Val Pro Tyr Arg Lys Leu 
    210                 215                 220                 


Asp Ser Ser Asp Val Ala Leu Asp Met Leu Asn Glu Leu Asn Arg Cys 
225                 230                 235                 240 


Pro Lys Ala Leu Tyr Asp Val Leu Ser Asp Glu Asp Arg Glu Arg Phe 
                245                 250                 255     


Ile Val Asp Asn Val Glu Asn Ala Asp Asn Arg Asp Glu Ile Ser Asp 
            260                 265                 270         


Glu Asp Asp Glu Glu Met Pro Arg Ser Val Met Lys Arg Ser Asp Asp 
        275                 280                 285             


Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Glu Lys Gln Asn Asn Leu 
    290                 295                 300                 


Asp Glu Ile Ser Phe His Leu Tyr Leu Gly Arg Lys Glu Ala Lys Pro 
305                 310                 315                 320 


Ala His Glu Lys Val Ile Asn Gly Glu Met Arg Thr His Lys Ile Leu 
                325                 330                 335     


Lys Asp Ile His Val Phe Gly Arg Leu Glu Asn Tyr Arg Asn Glu Glu 
            340                 345                 350         


Ile Cys Asn Ala Ile Lys Asn Arg Glu Asp Ile Glu Phe Tyr Ala Pro 
        355                 360                 365             


Ser Tyr Arg Ile Val Glu Asn Arg Ile Gly Leu Leu Leu Arg Arg Gln 
    370                 375                 380                 


Asn Asp Phe Thr Leu Glu Glu Ala Asn Glu Glu Lys Ile Phe Glu Gly 
385                 390                 395                 400 


Asn Leu Cys Pro Asp Val Ile Leu Ser Thr His Glu Leu Gly Ala Leu 
                405                 410                 415     


Phe Phe Tyr Asn Tyr Leu His Lys Lys Gly Trp Ile Glu Ser Ala Pro 
            420                 425                 430         


Tyr Leu Tyr Ile Arg Asn Phe Ile Ser Asp Phe Lys Arg Phe Ile Glu 
        435                 440                 445             


Asp Ile Lys Asn Gly Lys Leu Thr Pro Val Glu Ser Glu Asp Asp Phe 
    450                 455                 460                 


Tyr Leu Ile Lys Lys Lys Lys Arg Asp Glu Thr Lys Asp Asn Asp Lys 
465                 470                 475                 480 


Lys Ser Ile Ala Val Gln Glu Arg Arg Arg Glu Lys Leu Lys Glu Lys 
                485                 490                 495     


Leu Lys Gly Tyr His Leu Glu Pro Asp Trp Ile Pro Asp Ala Cys Arg 
            500                 505                 510         


Glu Tyr Met Leu Gly Tyr Lys Ala Asp Gln Lys Asp Tyr Tyr Thr Lys 
        515                 520                 525             


Gln Arg Phe Cys Ser Met Lys Lys Glu Thr Asp Ser Arg Ile Lys Gln 
    530                 535                 540                 


Ile Glu Ala Ile Arg Lys Arg Glu Asp Asn Ser Ile Ile Arg Gln Thr 
545                 550                 555                 560 


Arg Val Gly Glu Ile Ala Gln Glu Leu Ala Arg Asp Ile Val Phe Leu 
                565                 570                 575     


Ile Pro Pro Tyr Lys Asn Glu Lys Gly Ala Asp Thr Lys Ile Asn Asn 
            580                 585                 590         


Met Glu Phe Asp Val Leu Gln Lys Met Leu Ala Tyr Phe Pro Leu Asn 
        595                 600                 605             


Lys Lys Asp Ile Tyr Pro Phe Leu Lys Asn Ile Arg Asn Trp Asp Lys 
    610                 615                 620                 


His Pro Phe Leu Lys Tyr Thr Leu His Thr Glu His Gln Ser Leu Leu 
625                 630                 635                 640 


Asp Phe Tyr Gln Asp Tyr Leu Asn Cys Lys Lys Arg Trp Ile Ser Lys 
                645                 650                 655     


Asn Ile Arg Tyr Asp Lys Gln Lys Gly Asn Tyr Leu Val Asp Ala Asn 
            660                 665                 670         


Lys Thr Glu Gln Glu Cys Arg Tyr Phe Leu Lys Thr Asp Lys Leu Arg 
        675                 680                 685             


Thr Ala Lys Glu Lys Glu Tyr Phe Glu Glu Pro Asp Lys Pro Val Tyr 
    690                 695                 700                 


Leu Pro Thr Gly Phe Phe Val Asp Pro Ile Val Glu Ala Met Arg Lys 
705                 710                 715                 720 


Asn Gly Tyr Glu Leu Lys Glu Asn Ser Asn Ile Val Gly Cys Leu Lys 
                725                 730                 735     


Ile Tyr Phe Val Ser Lys Ile Gln Pro Met Tyr Asp Leu Ser Arg Tyr 
            740                 745                 750         


Tyr Thr Tyr Tyr Asp Gly Lys Glu Glu Arg Ser Met Gln Leu Asp Asp 
        755                 760                 765             


Leu Lys Val Phe Ile Lys Glu Lys Phe Gly Asn Lys Arg Thr Asp Asp 
    770                 775                 780                 


Asn Thr Ile Arg Phe Leu Lys Lys Ala Ala Lys Arg Ile Arg Glu Asn 
785                 790                 795                 800 


Glu Ser Glu Ile Leu Val Arg Gln Met Asp Asp Cys Ala Leu Phe Leu 
                805                 810                 815     


Met Val Asn Asp Leu Leu Glu Gly Gly Lys Phe Asn Asp Glu Asp Ile 
            820                 825                 830         


Glu Asn Ile Gly Tyr Asn Lys His His Asn Leu Leu Asp His Glu Tyr 
        835                 840                 845             


Asp Met Cys Glu Thr Ile Tyr Gly Arg Lys Val Thr Ala Arg Leu Pro 
    850                 855                 860                 


Ile Lys Arg Tyr Gly Glu Phe Arg Arg Phe Met Lys Asp Arg Arg Leu 
865                 870                 875                 880 


Gln Asn Leu Val Lys Tyr Tyr Pro Gly Asp His Glu Thr Pro Ile Pro 
                885                 890                 895     


Ser Gly Ile Pro Glu Ser Gly Lys Ala Met Glu Lys Asn Lys Lys Tyr 
            900                 905                 910         


Thr Tyr Ser Asn Leu Cys Asp Glu Leu Glu Ile Tyr Asp Lys Glu Arg 
        915                 920                 925             


Asp Asn Val Leu Asn Leu Ile Tyr Glu Val Asp Lys Ile Leu Val Asp 
    930                 935                 940                 


His Phe Pro Asp Lys Ile Met Lys Glu Glu Asp Gly Tyr Tyr Glu His 
945                 950                 955                 960 


Tyr His Cys Leu Asp Phe Ala Lys Lys Glu Phe Gly Leu Glu Ser Asp 
                965                 970                 975     


Val Glu Leu Leu Ser Gln Asp Asn Phe Lys Asp Leu Arg Asn Ala Leu 
            980                 985                 990         


Tyr His Asn Gln Ile Pro Tyr Asn  Asp Trp Val Ala Asp  Lys Ile Ser 
        995                 1000                 1005             


Lys Asp  Thr Glu Glu Pro Met  Tyr Val Arg Arg Ile  Phe Ser Phe 
    1010                 1015                 1020             


Ile Arg  Thr Val Tyr Ser Arg  Leu Leu Asp Gln Ile  Lys Ile Lys 
    1025                 1030                 1035             


Ile Glu  Lys Asp Glu Tyr Lys  Cys Lys 
    1040                 1045         


<210>  1475
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1475

Met Glu Thr Lys Gln Gln Val Gly Lys Gly Ile Ser Tyr Asp His Arg 
1               5                   10                  15      


Arg Pro Asp Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asp Gly Val Ile Gln Glu Phe Ala Met Arg Leu Asn Arg 
        35                  40                  45              


Glu Tyr Asp Pro Glu Asn Lys Asn Gln Ser Leu Phe Ser Tyr Phe Asn 
    50                  55                  60                  


Ile Asn Ala Ser Phe Thr Asp Trp Glu Arg Gly Val Asn Ile Leu Lys 
65                  70                  75                  80  


Glu Tyr Trp Pro Met Met Glu Phe Ile Asp Arg Pro Ala Thr Asp Lys 
                85                  90                  95      


Gln Phe Glu Ala Glu Lys Pro Glu Asn Arg Glu Ala Ala Lys Arg Lys 
            100                 105                 110         


Tyr Phe Leu Ala Thr Leu Gly Ala Leu Leu Thr Ser Ile Lys Asp Leu 
        115                 120                 125             


Arg His Tyr Tyr Thr His Tyr Tyr His Pro Pro Val His Leu Asn Asp 
    130                 135                 140                 


Asp Leu Phe Leu Phe Leu Asp His Ala Leu Leu Tyr Thr Ala Phe Asp 
145                 150                 155                 160 


Val Lys Lys Thr Lys Met Lys Asp Asp Lys Thr Arg Gln Leu Leu Asn 
                165                 170                 175     


Gln Asn Leu Ser Leu Glu Leu Glu Lys Leu Lys Lys Leu Lys Val Glu 
            180                 185                 190         


Glu Leu Lys Lys Lys Lys Glu Lys Gly Ile Lys Val Asn Leu Gln Asp 
        195                 200                 205             


Glu Lys Gly Ile Leu Asn Ala Ile Tyr Asn Asp Ala Phe Ala His Ile 
    210                 215                 220                 


Ile Thr Lys Glu Lys Asp Ser Asp Lys Asp Lys Leu Glu Thr Arg Tyr 
225                 230                 235                 240 


Lys Ser Ile Leu Pro Gln Asp Glu Ala Ala Glu Thr Gly Ile Asn Ile 
                245                 250                 255     


Ser Ile Ser Gly Leu Ile Phe Leu Leu Ser Leu Phe Leu Ser Arg Lys 
            260                 265                 270         


Glu Ile Glu Gln Leu Lys Ser Asn Ile Glu Gly Tyr Lys Gly Lys Val 
        275                 280                 285             


Leu Asn Ile Glu Thr Glu Val Asp Arg Lys His Asn Ser Leu Lys Tyr 
    290                 295                 300                 


Met Ala Thr His Trp Val Phe Ser Ile Leu Ala Phe Lys Gly Leu Lys 
305                 310                 315                 320 


Gln Arg Leu Thr Asn Ser Phe Glu Lys Glu Ser Leu Leu Ile Gln Met 
                325                 330                 335     


Met Asp Glu Leu Asn Lys Val Pro Asp Glu Leu Tyr Gln Thr Leu Ser 
            340                 345                 350         


Glu Thr Ala Lys Lys Glu Phe Leu Glu Asp Ile Asn Glu Tyr Val Ser 
        355                 360                 365             


Glu Gly Asp Asp Asn Glu Lys Ala Thr Tyr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Ser Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gln Phe Pro Thr Leu Lys Phe Gln Ile Phe Val Gly 
                405                 410                 415     


Gln Tyr Leu His Asp Asn Arg Pro Lys Thr Leu Ala Ser Asn Gly Met 
            420                 425                 430         


Thr Ala Gln Arg Met Ile Lys Glu Lys Ile Asn Leu Phe Gly Asn Leu 
        435                 440                 445             


Ser Glu Val Thr Lys His Lys Ser Asp Phe Phe Glu Lys Glu Ser Ala 
    450                 455                 460                 


Ala Gln Gly Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Trp Ala Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Val Tyr Ile Asp Met Ile Gly Lys Glu Gly Lys Ala 
                485                 490                 495     


Lys Glu Ile Gln Val Gln Ile Asn Lys Tyr Arg Lys Gln Leu Asn Pro 
            500                 505                 510         


Ala Pro Gln Arg Asp Lys Arg Ile Ser Lys Lys Glu Ile Ile Glu Gln 
        515                 520                 525             


Leu Tyr Lys Glu Lys Val Val Tyr Gly Asp Pro Thr Leu Met Leu Ser 
    530                 535                 540                 


Ala Asn Glu Leu Met Ala Leu Leu Tyr Glu Leu Ile Val Asn Gly Lys 
545                 550                 555                 560 


Ser Gly Ala Glu Leu Glu Asn Lys Ile Val Glu Gln Ile Ile Ala Arg 
                565                 570                 575     


Tyr Glu Gln Ile Glu Ala Tyr Asp Pro Thr Thr Gln Gln Leu Pro Thr 
            580                 585                 590         


Asn Gln Met Pro His Lys Leu Gln Lys Ser Arg Lys Asp Ser Lys Val 
        595                 600                 605             


Thr Asp Thr Asp Lys Leu Leu Lys Thr Ile Asp Lys Glu Ile Asp Glu 
    610                 615                 620                 


Gly Asn Lys Lys Leu Glu Leu Ile Ala Cys His Arg Lys Glu Trp Glu 
625                 630                 635                 640 


Glu Ala Glu Gln Arg Lys Lys Ser Gly Lys Arg Asn Asn Pro Gly Thr 
                645                 650                 655     


Lys Ser Arg Lys His Leu Phe Tyr Ala Ser Glu Met Gly Glu Glu Ala 
            660                 665                 670         


Thr Trp Ile Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Pro Ala Arg 
        675                 680                 685             


Ala Glu Trp Lys Gly Thr His His Ser Glu Leu Gln Arg Leu Leu Ala 
    690                 695                 700                 


Phe Tyr Ser Thr Gln Arg Leu Glu Ala Trp Gln Leu Val Glu Ser Val 
705                 710                 715                 720 


Trp Thr Ala Asn Thr His Ser Phe Trp Glu Glu Asn Phe Lys Glu Ala 
                725                 730                 735     


Phe Tyr Lys Pro Glu Phe Glu Asn Phe Tyr Gly Ala Tyr Ile Glu Ile 
            740                 745                 750         


Arg Thr Lys Ile Leu Thr Thr Cys Arg Ser Ile Leu Glu Asn Asn Pro 
        755                 760                 765             


Glu Ala Thr Met Asn Asn Asp Thr Glu Lys Glu Trp Asp Lys Val Phe 
    770                 775                 780                 


Thr Leu Phe Asp Lys Arg Leu Tyr Arg Thr Ser Thr Thr Asp Glu Gln 
785                 790                 795                 800 


Lys Lys Gln Leu Leu Thr Lys Pro Phe Ala Phe Pro Arg Gly Leu Phe 
                805                 810                 815     


Asp Asp Lys Pro Thr Phe Leu Pro Gly Ser Lys Pro Asn Glu Asn Pro 
            820                 825                 830         


Glu Arg Phe Ala Ala Trp Tyr Ser Tyr Gly Tyr Thr Tyr Ser Gly Lys 
        835                 840                 845             


Phe Gln Ser Phe Tyr Asp Met Pro Arg Asn Tyr Ser Asp Trp Tyr Lys 
    850                 855                 860                 


Lys Leu Lys Glu Asp Gly Lys Leu Pro Arg Leu Asp Lys Lys Thr Glu 
865                 870                 875                 880 


Gln Glu Lys Ile Leu Arg Phe Arg Met Asp Cys Asp Leu Asn Ile Lys 
                885                 890                 895     


His Ile Arg Phe Gln Asp Ile Tyr Val Lys Leu Met Val Asp Ser Leu 
            900                 905                 910         


Tyr Lys Ala Val Phe Gly Gln Gln Pro Glu Phe Asp Leu Ser His Leu 
        915                 920                 925             


Tyr Asp Thr Arg Ser Glu Arg Tyr Glu Asn Asn Thr Ile Ala Gln Arg 
    930                 935                 940                 


Gln Lys Ser Arg Gln Glu Gly Asp Asn Ser Asp Asn Ala Ile Asn Glu 
945                 950                 955                 960 


Asn Tyr Val Trp Asn Lys Thr Phe Ala Ile Ser Leu Tyr Asn Gly Arg 
                965                 970                 975     


Ile Thr Glu Ser Gln Val Lys Leu Lys Asp Val Gly Lys Phe Arg Arg 
            980                 985                 990         


Phe Ala Thr Asp Pro Arg Val Gln  Thr Leu Ile Ser Tyr  Asp Asp Thr 
        995                 1000                 1005             


Arg Thr  Trp Thr Lys Leu Glu  Ile Glu Asn Glu Leu  Asp Asn Lys 
    1010                 1015                 1020             


Ala Asp  Ala Tyr Glu Pro Ile  Arg Arg Thr Gln Ser  Leu Lys Ala 
    1025                 1030                 1035             


Ile Gln  Gln Leu Glu Lys Asn  Ile Leu Lys Lys Asn  Gly Phe Asn 
    1040                 1045                 1050             


Gly Lys  Gln His Pro Glu Glu  Leu Lys His Asn Gly  Asn Pro Asn 
    1055                 1060                 1065             


Phe Arg  Lys Tyr Ile Ala Asn  Gly Leu Leu Lys His  Arg Thr Asp 
    1070                 1075                 1080             


Ile Arg  Gln Glu Glu Leu Ala  Leu Ile Ser Asp Thr  Glu Phe Gln 
    1085                 1090                 1095             


Glu Ile  Gly Leu Glu Arg Ile  Arg Gln Thr Asn Pro  Leu Ile Gln 
    1100                 1105                 1110             


Lys Ala  Tyr Leu Leu Ile Leu  Leu Arg Asn Lys Phe  Gly His Asn 
    1115                 1120                 1125             


Gln Leu  Pro Asp Gln Glu His  Phe Arg Leu Met Arg  Ser Ile Tyr 
    1130                 1135                 1140             


Pro Tyr  Asn Gln Gln Glu Ser  Tyr Ser Ala Tyr Phe  Asn His Val 
    1145                 1150                 1155             


Ile Thr  Gln Ile Ile Glu Glu  Leu Asn Thr 
    1160                 1165             


<210>  1476
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1476

Met Glu Thr Lys Gln Gln Val Gly Lys Gly Ile Ser Tyr Asp His Arg 
1               5                   10                  15      


Arg Pro Asp Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asp Gly Val Ile Gln Glu Phe Ala Met Arg Leu Asn Arg 
        35                  40                  45              


Glu Tyr Asp Pro Glu Asn Lys Asn Gln Ser Leu Phe Ser Tyr Phe Asn 
    50                  55                  60                  


Ile Asn Ala Ser Phe Thr Asp Trp Glu Arg Gly Val Asn Ile Leu Lys 
65                  70                  75                  80  


Glu Tyr Trp Pro Met Met Glu Phe Ile Asp Arg Pro Ala Thr Asp Lys 
                85                  90                  95      


Gln Phe Glu Ala Glu Lys Pro Glu Asn Arg Glu Ala Ala Lys Arg Lys 
            100                 105                 110         


Tyr Phe Leu Ala Thr Leu Gly Ala Leu Leu Thr Ser Ile Lys Asp Leu 
        115                 120                 125             


Arg His Tyr Tyr Thr His Tyr Tyr His Pro Pro Val His Leu Asn Asp 
    130                 135                 140                 


Asp Leu Phe Leu Phe Leu Asp His Ala Leu Leu Tyr Thr Ala Phe Asp 
145                 150                 155                 160 


Val Lys Lys Thr Lys Met Lys Asp Asp Lys Thr Arg Gln Leu Leu Asn 
                165                 170                 175     


Gln Asn Leu Ser Leu Glu Leu Glu Lys Leu Lys Lys Leu Lys Val Glu 
            180                 185                 190         


Glu Leu Lys Lys Lys Lys Glu Lys Gly Ile Lys Val Asn Leu Gln Asp 
        195                 200                 205             


Glu Lys Gly Ile Leu Asn Ala Ile Tyr Asn Asp Ala Phe Ala His Ile 
    210                 215                 220                 


Ile Thr Lys Glu Lys Asp Ser Asp Lys Asp Lys Leu Glu Thr Arg Tyr 
225                 230                 235                 240 


Lys Ser Ile Leu Pro Gln Asp Glu Ala Ala Glu Thr Gly Ile Asn Ile 
                245                 250                 255     


Ser Ile Ser Gly Leu Ile Phe Leu Leu Ser Leu Phe Leu Ser Arg Lys 
            260                 265                 270         


Glu Ile Glu Gln Leu Lys Ser Asn Ile Glu Gly Tyr Lys Gly Lys Val 
        275                 280                 285             


Leu Asn Ile Glu Thr Glu Val Asp Arg Lys His Asn Ser Leu Lys Tyr 
    290                 295                 300                 


Met Ala Thr His Trp Val Phe Ser Ile Leu Ala Phe Lys Gly Leu Lys 
305                 310                 315                 320 


Gln Arg Leu Thr Asn Ser Phe Glu Lys Glu Ser Leu Leu Ile Gln Met 
                325                 330                 335     


Met Asp Glu Leu Asn Lys Val Pro Asp Glu Leu Tyr Gln Thr Leu Ser 
            340                 345                 350         


Glu Thr Ala Lys Lys Glu Phe Leu Glu Asp Ile Asn Glu Tyr Val Ser 
        355                 360                 365             


Glu Gly Asp Asp Asn Glu Lys Ala Thr Tyr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Ser Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gln Phe Pro Thr Leu Lys Phe Gln Ile Phe Val Gly 
                405                 410                 415     


Gln Tyr Leu His Asp Asn Arg Pro Lys Thr Leu Ala Ser Asn Gly Met 
            420                 425                 430         


Thr Ala Gln Arg Met Ile Lys Glu Lys Ile Asn Leu Phe Gly Asn Leu 
        435                 440                 445             


Ser Glu Val Thr Lys His Lys Ser Asp Phe Phe Glu Lys Glu Ser Ala 
    450                 455                 460                 


Ala Gln Gly Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Trp Ala Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Val Tyr Ile Asp Met Ile Gly Lys Glu Gly Lys Ala 
                485                 490                 495     


Lys Glu Ile Gln Val Gln Ile Asn Lys Tyr Arg Lys Gln Leu Asn Pro 
            500                 505                 510         


Ala Pro Gln Arg Asp Lys Arg Ile Ser Lys Lys Glu Ile Ile Glu Gln 
        515                 520                 525             


Leu Tyr Lys Glu Lys Val Val Tyr Gly Asp Pro Thr Leu Met Leu Ser 
    530                 535                 540                 


Ala Asn Glu Leu Met Ala Leu Leu Tyr Glu Leu Ile Val Asn Gly Lys 
545                 550                 555                 560 


Ser Gly Ala Glu Leu Glu Asn Lys Ile Val Glu Gln Ile Ile Ala Arg 
                565                 570                 575     


Tyr Glu Gln Ile Glu Ala Tyr Asp Pro Thr Thr Gln Gln Leu Pro Thr 
            580                 585                 590         


Asn Gln Met Pro His Lys Leu Gln Lys Ser Arg Lys Asp Ser Lys Val 
        595                 600                 605             


Thr Asp Thr Asp Lys Leu Leu Lys Thr Ile Asp Lys Glu Ile Asp Glu 
    610                 615                 620                 


Gly Asn Lys Lys Leu Glu Leu Ile Ala Cys His Arg Lys Glu Trp Glu 
625                 630                 635                 640 


Glu Ala Glu Gln Arg Lys Lys Ser Gly Lys Arg Asn Asn Pro Gly Thr 
                645                 650                 655     


Lys Ser Arg Lys His Leu Phe Tyr Ala Ser Glu Met Gly Glu Glu Ala 
            660                 665                 670         


Thr Trp Ile Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Pro Ala Arg 
        675                 680                 685             


Ala Glu Trp Lys Gly Thr His His Ser Glu Leu Gln Arg Leu Leu Ala 
    690                 695                 700                 


Phe Tyr Ser Thr Gln Arg Leu Glu Ala Trp Gln Leu Val Glu Ser Val 
705                 710                 715                 720 


Trp Thr Ala Asn Thr His Ser Phe Trp Glu Glu Asn Phe Lys Glu Ala 
                725                 730                 735     


Phe Tyr Lys Pro Glu Phe Glu Asn Phe Tyr Gly Ala Tyr Ile Glu Ile 
            740                 745                 750         


Arg Thr Lys Ile Leu Thr Thr Cys Arg Ser Ile Leu Glu Asn Asn Pro 
        755                 760                 765             


Glu Ala Thr Met Asn Asn Asp Thr Glu Lys Glu Trp Asp Lys Val Phe 
    770                 775                 780                 


Thr Leu Phe Asp Lys Arg Leu Tyr Arg Thr Ser Thr Thr Asp Glu Gln 
785                 790                 795                 800 


Lys Lys Gln Leu Leu Thr Lys Pro Phe Ala Phe Pro Arg Gly Leu Phe 
                805                 810                 815     


Asp Asp Lys Pro Thr Phe Leu Pro Gly Ser Lys Pro Asn Glu Asn Pro 
            820                 825                 830         


Glu Arg Phe Ala Ala Trp Tyr Ser Tyr Gly Tyr Thr Tyr Ser Gly Lys 
        835                 840                 845             


Phe Gln Ser Phe Tyr Asp Met Pro Arg Asn Tyr Ser Asp Trp Tyr Lys 
    850                 855                 860                 


Lys Leu Lys Glu Asp Gly Lys Leu Pro Arg Leu Asp Lys Lys Thr Glu 
865                 870                 875                 880 


Gln Glu Lys Ile Leu Arg Phe Arg Met Asp Cys Asp Leu Asn Ile Lys 
                885                 890                 895     


His Ile Arg Phe Gln Asp Ile Tyr Val Lys Leu Met Val Asp Ser Leu 
            900                 905                 910         


Tyr Lys Ala Val Phe Gly Gln Gln Pro Glu Phe Asp Leu Ser His Leu 
        915                 920                 925             


Tyr Asp Thr Arg Ser Glu Arg Tyr Glu Asn Asn Thr Ile Ala Gln Arg 
    930                 935                 940                 


Gln Lys Ser Arg Gln Glu Gly Asp Asn Ser Asp Asn Ala Ile Asn Glu 
945                 950                 955                 960 


Asn Tyr Val Trp Asn Lys Thr Phe Ala Ile Ser Leu Tyr Asn Gly Arg 
                965                 970                 975     


Ile Thr Glu Ser Gln Val Lys Leu Lys Asp Val Gly Lys Phe Arg Arg 
            980                 985                 990         


Phe Ala Thr Asp Pro Arg Val Gln  Thr Leu Ile Ser Tyr  Asp Asp Thr 
        995                 1000                 1005             


Arg Thr  Trp Thr Lys Leu Glu  Ile Glu Asn Glu Leu  Asp Asn Lys 
    1010                 1015                 1020             


Ala Asp  Ala Tyr Glu Pro Ile  Arg Arg Thr Gln Ser  Leu Lys Ala 
    1025                 1030                 1035             


Ile Gln  Gln Leu Glu Lys Asn  Ile Leu Lys Lys Asn  Gly Phe Asn 
    1040                 1045                 1050             


Gly Lys  Gln His Pro Glu Glu  Leu Lys His Asn Gly  Asn Pro Asn 
    1055                 1060                 1065             


Phe Arg  Lys Tyr Ile Ala Asn  Gly Leu Leu Lys His  Arg Thr Asp 
    1070                 1075                 1080             


Ile Arg  Gln Glu Glu Leu Ala  Leu Ile Ser Asp Thr  Glu Phe Gln 
    1085                 1090                 1095             


Glu Ile  Gly Leu Glu Arg Ile  Arg Gln Thr Asn Pro  Leu Ile Gln 
    1100                 1105                 1110             


Lys Ala  Tyr Leu Leu Ile Leu  Leu Arg Asn Lys Phe  Gly His Asn 
    1115                 1120                 1125             


Gln Leu  Pro Asp Gln Glu His  Phe Arg Leu Met Arg  Ser Ile Tyr 
    1130                 1135                 1140             


Pro Tyr  Asn Gln Gln Glu Ser  Tyr Ser Ala Tyr Phe  Asn His Val 
    1145                 1150                 1155             


Ile Thr  Gln Ile Ile Glu Glu  Leu Asn Thr 
    1160                 1165             


<210>  1477
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1477

Met Glu Thr Lys Gln Gln Val Gly Lys Gly Ile Ser Tyr Asp His Arg 
1               5                   10                  15      


Arg Pro Asp Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asp Gly Val Ile Gln Glu Phe Ala Met Arg Leu Asn Arg 
        35                  40                  45              


Glu Tyr Asp Pro Glu Asn Lys Asn Gln Ser Leu Phe Ser Tyr Phe Asn 
    50                  55                  60                  


Ile Asn Ala Ser Phe Thr Asp Trp Glu Arg Gly Val Asn Ile Leu Lys 
65                  70                  75                  80  


Glu Tyr Trp Pro Met Met Glu Phe Ile Asp Arg Pro Ala Thr Asp Lys 
                85                  90                  95      


Gln Phe Glu Ala Glu Lys Pro Glu Asn Arg Glu Ala Ala Lys Arg Lys 
            100                 105                 110         


Tyr Phe Leu Ala Thr Leu Gly Ala Leu Leu Thr Ser Ile Lys Asp Leu 
        115                 120                 125             


Arg His Tyr Tyr Thr His Tyr Tyr His Pro Pro Val His Leu Asn Asp 
    130                 135                 140                 


Asp Leu Phe Leu Phe Leu Asp His Ala Leu Leu Tyr Thr Ala Phe Asp 
145                 150                 155                 160 


Val Lys Lys Thr Lys Met Lys Asp Asp Lys Thr Arg Gln Leu Leu Asn 
                165                 170                 175     


Gln Asn Leu Ser Leu Glu Leu Glu Lys Leu Lys Lys Leu Lys Val Glu 
            180                 185                 190         


Glu Leu Lys Lys Lys Lys Glu Lys Gly Ile Lys Val Asn Leu Gln Asp 
        195                 200                 205             


Glu Lys Gly Ile Leu Asn Ala Ile Tyr Asn Asp Ala Phe Ala His Ile 
    210                 215                 220                 


Ile Thr Lys Glu Lys Asp Ser Asp Lys Asp Lys Leu Glu Thr Arg Tyr 
225                 230                 235                 240 


Lys Ser Ile Leu Pro Gln Asp Glu Ala Ala Glu Thr Gly Ile Asn Ile 
                245                 250                 255     


Ser Ile Ser Gly Leu Ile Phe Leu Leu Ser Leu Phe Leu Ser Arg Lys 
            260                 265                 270         


Glu Ile Glu Gln Leu Lys Ser Asn Ile Glu Gly Tyr Lys Gly Lys Val 
        275                 280                 285             


Leu Asn Ile Glu Thr Glu Val Asp Arg Lys His Asn Ser Leu Lys Tyr 
    290                 295                 300                 


Met Ala Thr His Trp Val Phe Ser Ile Leu Ala Phe Lys Gly Leu Lys 
305                 310                 315                 320 


Gln Arg Leu Thr Asn Ser Phe Glu Lys Glu Ser Leu Leu Ile Gln Met 
                325                 330                 335     


Met Asp Glu Leu Asn Lys Val Pro Asp Glu Leu Tyr Gln Thr Leu Ser 
            340                 345                 350         


Glu Thr Ala Lys Lys Glu Phe Leu Glu Asp Ile Asn Glu Tyr Val Ser 
        355                 360                 365             


Glu Gly Asp Asp Asn Glu Lys Ala Thr Tyr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Ser Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gln Phe Pro Thr Leu Lys Phe Gln Ile Phe Val Gly 
                405                 410                 415     


Gln Tyr Leu His Asp Asn Arg Pro Lys Thr Leu Ala Ser Asn Gly Met 
            420                 425                 430         


Thr Ala Gln Arg Met Ile Lys Glu Lys Ile Asn Leu Phe Gly Asn Leu 
        435                 440                 445             


Ser Glu Val Thr Lys His Lys Ser Asp Phe Phe Glu Lys Glu Ser Ala 
    450                 455                 460                 


Ala Gln Gly Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Trp Ala Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Val Tyr Ile Asp Met Ile Gly Lys Glu Gly Lys Ala 
                485                 490                 495     


Lys Glu Ile Gln Val Gln Ile Asn Lys Tyr Arg Lys Gln Leu Asn Pro 
            500                 505                 510         


Ala Pro Gln Arg Asp Lys Arg Ile Ser Lys Lys Glu Ile Ile Glu Gln 
        515                 520                 525             


Leu Tyr Lys Glu Lys Val Val Tyr Gly Asp Pro Thr Leu Met Leu Ser 
    530                 535                 540                 


Ala Asn Glu Leu Met Ala Leu Leu Tyr Glu Leu Ile Val Asn Gly Lys 
545                 550                 555                 560 


Ser Gly Ala Glu Leu Glu Asn Lys Ile Val Glu Gln Ile Ile Ala Arg 
                565                 570                 575     


Tyr Glu Gln Ile Glu Ala Tyr Asp Pro Thr Thr Gln Gln Leu Pro Thr 
            580                 585                 590         


Asn Gln Met Pro His Lys Leu Gln Lys Ser Arg Lys Asp Ser Lys Val 
        595                 600                 605             


Thr Asp Thr Asp Lys Leu Leu Lys Thr Ile Asp Lys Glu Ile Asp Glu 
    610                 615                 620                 


Gly Asn Lys Lys Leu Glu Leu Ile Ala Cys His Arg Lys Glu Trp Glu 
625                 630                 635                 640 


Glu Ala Glu Gln Arg Lys Lys Ser Gly Lys Arg Asn Asn Pro Gly Thr 
                645                 650                 655     


Lys Ser Arg Lys His Leu Phe Tyr Ala Ser Glu Met Gly Glu Glu Ala 
            660                 665                 670         


Thr Trp Ile Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Pro Ala Arg 
        675                 680                 685             


Ala Glu Trp Lys Gly Thr His His Ser Glu Leu Gln Arg Leu Leu Ala 
    690                 695                 700                 


Phe Tyr Ser Thr Gln Arg Leu Glu Ala Trp Gln Leu Val Glu Ser Val 
705                 710                 715                 720 


Trp Thr Ala Asn Thr His Ser Phe Trp Glu Glu Asn Phe Lys Glu Ala 
                725                 730                 735     


Phe Tyr Lys Pro Glu Phe Glu Asn Phe Tyr Gly Ala Tyr Ile Glu Ile 
            740                 745                 750         


Arg Thr Lys Ile Leu Thr Thr Cys Arg Ser Ile Leu Glu Asn Asn Pro 
        755                 760                 765             


Glu Ala Thr Met Asn Asn Asp Thr Glu Lys Glu Trp Asp Lys Val Phe 
    770                 775                 780                 


Thr Leu Phe Asp Lys Arg Leu Tyr Arg Thr Ser Thr Thr Asp Glu Gln 
785                 790                 795                 800 


Lys Lys Gln Leu Leu Thr Lys Pro Phe Ala Phe Pro Arg Gly Leu Phe 
                805                 810                 815     


Asp Asp Lys Pro Thr Phe Leu Pro Gly Ser Lys Pro Asn Glu Asn Pro 
            820                 825                 830         


Glu Arg Phe Ala Ala Trp Tyr Ser Tyr Gly Tyr Thr Tyr Ser Gly Lys 
        835                 840                 845             


Phe Gln Ser Phe Tyr Asp Met Pro Arg Asn Tyr Ser Asp Trp Tyr Lys 
    850                 855                 860                 


Lys Leu Lys Glu Asp Gly Lys Leu Pro Arg Leu Asp Lys Lys Thr Glu 
865                 870                 875                 880 


Gln Glu Lys Ile Leu Arg Phe Arg Met Asp Cys Asp Leu Asn Ile Lys 
                885                 890                 895     


His Ile Arg Phe Gln Asp Ile Tyr Val Lys Leu Met Val Asp Ser Leu 
            900                 905                 910         


Tyr Lys Ala Val Phe Gly Gln Gln Pro Glu Phe Asp Leu Ser His Leu 
        915                 920                 925             


Tyr Asp Thr Arg Ser Glu Arg Tyr Glu Asn Asn Thr Ile Ala Gln Arg 
    930                 935                 940                 


Gln Lys Ser Arg Gln Glu Gly Asp Asn Ser Asp Asn Ala Ile Asn Glu 
945                 950                 955                 960 


Asn Tyr Val Trp Asn Lys Thr Phe Ala Ile Ser Leu Tyr Asn Gly Arg 
                965                 970                 975     


Ile Thr Glu Ser Gln Val Lys Leu Lys Asp Val Gly Lys Phe Arg Arg 
            980                 985                 990         


Phe Ala Thr Asp Pro Arg Val Gln  Thr Leu Ile Ser Tyr  Asp Asp Thr 
        995                 1000                 1005             


Arg Thr  Trp Thr Lys Leu Glu  Ile Glu Asn Glu Leu  Asp Asn Lys 
    1010                 1015                 1020             


Ala Asp  Ala Tyr Glu Pro Ile  Arg Arg Thr Gln Ser  Leu Lys Ala 
    1025                 1030                 1035             


Ile Gln  Gln Leu Glu Lys Asn  Ile Leu Lys Lys Asn  Gly Phe Asn 
    1040                 1045                 1050             


Gly Lys  Gln His Pro Glu Glu  Leu Lys His Asn Gly  Asn Pro Asn 
    1055                 1060                 1065             


Phe Arg  Lys Tyr Ile Ala Asn  Gly Leu Leu Lys His  Arg Thr Asp 
    1070                 1075                 1080             


Ile Arg  Gln Glu Glu Leu Ala  Leu Ile Ser Asp Thr  Glu Phe Gln 
    1085                 1090                 1095             


Glu Ile  Gly Leu Glu Arg Ile  Arg Gln Thr Asn Pro  Leu Ile Gln 
    1100                 1105                 1110             


Lys Ala  Tyr Leu Leu Ile Leu  Leu Arg Asn Lys Phe  Gly His Asn 
    1115                 1120                 1125             


Gln Leu  Pro Asp Gln Glu His  Phe Arg Leu Met Arg  Ser Ile Tyr 
    1130                 1135                 1140             


Pro Tyr  Asn Gln Gln Glu Ser  Tyr Ser Ala Tyr Phe  Asn His Val 
    1145                 1150                 1155             


Ile Thr  Gln Ile Ile Glu Glu  Leu Asn Thr 
    1160                 1165             


<210>  1478
<211>  1129
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1478

Met Glu Thr Asn Gln Gln Thr His Glu Asn Arg Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Asn Asn His Val Ala Thr Asp Phe Lys Arg Lys Pro 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Asp Ala Leu Leu Cys Asn Lys Thr 
    50                  55                  60                  


Ile Lys Asn Leu Asn Trp Asn His Val His Thr Arg Ala Leu Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ser Glu Ser Leu Pro Lys Asp Glu 
                85                  90                  95      


Arg Lys Asn Ser Asp Thr Glu Gly Lys Asp Phe Thr Ser Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Ser Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Asp Ser Arg Lys Leu Ile Val 
    130                 135                 140                 


Ser Pro Glu Leu Ala Asn Phe Leu Thr Ile Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Thr Tyr Thr Lys Ala Arg Met Lys Asp Val Leu Thr Asp Ala Asp Tyr 
                165                 170                 175     


Ala Leu Val Glu Asn Leu Gln Met Val Ala Thr Asp Asn Lys Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ala Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asn Gln Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Ser 
            260                 265                 270         


Ile Ile Thr Asp Lys Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Glu Asn Leu Ile Ala Asn Ser Thr Asn Asn Glu Glu Arg 
    290                 295                 300                 


Glu Arg Ile Leu Asp Glu Ile Asp Tyr Gln Asp Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg Tyr Asn Asn Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Asp Glu Lys Asn Ile Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Asn Tyr Thr Lys Gln Phe Ala Gly Glu 
        355                 360                 365             


Gln Ala Glu Arg Lys Val Leu Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asp Pro Glu Leu Ser Gln Gln Arg Ile Asp Lys Gln 
385                 390                 395                 400 


Gln Gln Thr Ala Gly Phe Glu Gln Phe Ala Pro Arg Tyr His Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Asn Ile Ala Thr Leu Thr 
            420                 425                 430         


Ala Lys Ser Lys Ala Gly Ser Lys Val Glu His Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Gln Ala Glu Glu Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Ile Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Ser Gln Leu Pro Asp Gly Trp Asn Glu Phe Asn Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asp Ser Thr Leu Arg Tyr Leu 
        515                 520                 525             


His Gln Arg Lys Thr Ile Leu Asn Thr Ile Leu Ser Lys Tyr Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Lys Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Thr Arg Leu Lys Ala Val Glu Lys His Lys Leu 
            580                 585                 590         


Asn Lys Ser Val Lys Ile Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Glu Glu Lys Lys Lys Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Thr Asn Ala Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Asn Asp Gly His Pro Phe Leu Gln Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Gln Ala Tyr Leu Ile 
        675                 680                 685             


Glu Lys Gly Asn Lys Met Val Pro Arg Leu Asn Pro Lys Thr Asn Lys 
    690                 695                 700                 


Thr Ser Lys Val Asp Glu Ser Trp Met Met Lys Gln Phe Tyr Val Lys 
705                 710                 715                 720 


Glu Trp Lys Glu Glu Ile Ala Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Ser Arg Ile Pro Phe Thr Ile Arg Gln Trp Asp Glu Lys 
            740                 745                 750         


Glu Lys Tyr Asp Leu Asn Thr Trp Leu Arg His Val Thr Val Gly Lys 
        755                 760                 765             


Asn Asn Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe Asp 
    770                 775                 780                 


Glu Ala Leu Cys Asp Leu Leu Arg Glu Gln Leu Asp Thr Lys Ile Val 
785                 790                 795                 800 


Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Ile Trp Trp 
                805                 810                 815     


Lys Thr Arg Asn Asp Asp Thr Gln Gln Phe Tyr Gln Ser Glu Arg Glu 
            820                 825                 830         


Tyr Asn Ile Tyr Asn Glu Lys Val Arg Phe Lys Ile Asp Ser Ser Ala 
        835                 840                 845             


His Phe Ala Asp Tyr Tyr Lys Asn Ala Leu Ser Arg Ala Phe Thr Arg 
    850                 855                 860                 


Leu Lys Ala Glu Arg Glu Thr Ala Arg Gln Ser Asn Lys Arg Leu Pro 
865                 870                 875                 880 


Pro Leu Glu Tyr Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile Ala 
                885                 890                 895     


Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met Ala 
            900                 905                 910         


Val Leu Met Leu Glu Arg Leu Met Asp Asn Ser Pro Asn Leu Arg Leu 
        915                 920                 925             


Ser Lys Ile Glu Thr Leu Leu Asn Asp Thr Thr Pro Ile Arg Glu Lys 
    930                 935                 940                 


Ile Ser Ala Thr Leu Ser Phe Asp Ala Ser Gly Glu Arg Ile Ser Gly 
945                 950                 955                 960 


Lys Ser Asn Pro Thr Val Thr Lys Thr Leu Val Ala Glu Arg Lys Gln 
                965                 970                 975     


Lys Asn Tyr Thr Glu Leu Arg Lys Tyr Arg Tyr Asp Arg Arg Leu Pro 
            980                 985                 990         


Glu Leu Phe Glu Tyr Val Gln Ala  Asp Glu Ile Pro Leu  Glu Trp Leu 
        995                 1000                 1005             


Leu Glu  Glu Leu Ser Ala Tyr  Asn Asn Ala Lys Gln  Gln Val Phe 
    1010                 1015                 1020             


Asp Thr  Val Phe Thr Leu Glu  Lys Lys Ile Ile Gly  Thr Asp Pro 
    1025                 1030                 1035             


Asp Gly  Leu Lys Ser Leu Phe  Thr Gly Ala Asn Gly  Glu Leu Gln 
    1040                 1045                 1050             


Thr Gly  Asn Ile Gln His Lys  Pro Tyr Val Gln Trp  Leu Thr Asn 
    1055                 1060                 1065             


Lys Gly  Leu Ile Asn Lys Glu  Glu Lys Gln Phe Ile  Asn Met Val 
    1070                 1075                 1080             


Arg Lys  Cys Phe Ser His Asn  Gln Phe Pro Gln Arg  Lys Thr Met 
    1085                 1090                 1095             


Glu Leu  Leu Ile Pro Ala Trp  Asn Glu Lys Lys Leu  Ala Leu Gln 
    1100                 1105                 1110             


Ile Ala  Thr Val Tyr Asn Gln  Leu Ile Ala Asp Leu  Thr Asn Lys 
    1115                 1120                 1125             


Ile 
    


<210>  1479
<211>  1013
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1479

Met Glu Ile Leu Thr Ile Pro Glu Val Ile Lys Cys Arg Thr Leu Ser 
1               5                   10                  15      


Asp Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Val Leu Asn Ile Ser Asn His Ile Ala Lys Glu Phe Lys Leu Pro Leu 
        35                  40                  45              


Leu Pro Glu Glu Ala His Leu Lys Asn Ser Phe Leu Cys Lys Lys Glu 
    50                  55                  60                  


Asn Lys Lys Ile Asp Trp Asn His Val Tyr Ala Arg Thr Ile Arg Phe 
65                  70                  75                  80  


Leu Ser Val Met Lys Val Phe Asp Ala Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Lys Thr Ile Asp Trp Glu Gly Lys Asp Phe Ala Ser Met Cys Asp 
            100                 105                 110         


Thr Leu Asn Ile Val Phe Ser Glu Leu Gln Glu Phe Ser Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Glu Thr Lys Arg Lys Thr Thr Val 
    130                 135                 140                 


Ser Asp Glu Leu Ala Leu Phe Leu Arg Thr Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Glu Tyr Thr Lys Val Arg Phe Lys Gly Ile Leu Asn Asp Glu Asp Tyr 
                165                 170                 175     


Gln Leu Val Val Ser Lys Lys Met Leu Glu Thr Asn His Thr Ile Thr 
            180                 185                 190         


His Glu Gly Leu Val Phe Leu Thr Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Arg Phe Ile Arg Lys Ile His Gly Leu Ser Gly Pro Lys Asp 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Cys Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro Gln Glu Gln Phe Arg Ser Asp Asn Arg Arg Gln Ala Ile Ser 
                245                 250                 255     


Leu Glu Leu Met Asn Glu Leu Lys Lys Cys Pro Lys Val Leu Tyr His 
            260                 265                 270         


Val Ile Thr Glu Glu Trp Lys Gln Lys Leu Lys Ser Val Pro Glu Glu 
        275                 280                 285             


Leu Glu Thr Lys Asn Leu His Tyr Asn Thr Lys Arg Glu Thr Lys Ile 
    290                 295                 300                 


Glu Phe Glu Asp Tyr Asp Leu Tyr Ile Glu Ser Leu Thr Lys Gln Val 
305                 310                 315                 320 


Arg Tyr Asn Asn Arg Phe Ser Glu Phe Ala Leu Lys Tyr Ile Asp Glu 
                325                 330                 335     


Thr Gly Ile Phe Ser Glu Phe Arg Phe Gln Leu Asp Leu Gly Lys Ile 
            340                 345                 350         


Leu Val Asp Glu Tyr Leu Lys Asn Phe Asn Asp Glu Arg Val Gln Arg 
        355                 360                 365             


Cys Ile Ile Glu Asn Ala Lys Ala Phe Gly Lys Leu Asn Asp Tyr Thr 
    370                 375                 380                 


Asn Glu Thr Lys Val Met Ser Leu Ile Val Asn Gly Pro Pro Leu Lys 
385                 390                 395                 400 


Ser Phe Asp Arg Phe Ala Pro His Tyr Asn Ile Glu Ser Asn Lys Ile 
                405                 410                 415     


Gly Ile Ser Thr His Glu Val Thr Ala Lys Leu Val Pro Asn Ser Lys 
            420                 425                 430         


Gly Glu Pro Ala Lys Lys Leu His Gln Pro Leu Pro Glu Ala Phe Leu 
        435                 440                 445             


Ser Leu His Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu Gln Lys 
    450                 455                 460                 


Gly Glu Pro Glu Lys Leu Ile Asn Glu Phe Ile Leu Val Asn Asn Ser 
465                 470                 475                 480 


Lys Leu Met Asn Met Ser Phe Ile Glu Glu Val Lys Asn Gln Leu Pro 
                485                 490                 495     


Lys Glu Trp Asp Lys Phe Gln Arg Arg Thr Asn Ala Lys His Glu Leu 
            500                 505                 510         


Ala Tyr Asp Glu Asn Thr Leu Ala Phe Leu Leu Gln Arg Lys Gln Ile 
        515                 520                 525             


Leu Asn Lys Thr Leu Leu Ala Tyr Gln Leu Asn Asp Lys Gln Ile Pro 
    530                 535                 540                 


Thr Arg Ile Leu Asp Tyr Trp Leu Asn Ile Ser Asp Ala Asp Glu Glu 
545                 550                 555                 560 


Arg Ala Ile Ser Asn Arg Leu Lys Ser Ile Lys Arg Asp Cys Met Ser 
                565                 570                 575     


Arg Leu Lys Ala Leu Ser Lys Phe Asn Glu Asn Gly Asn Arg Asn Lys 
            580                 585                 590         


Ile Pro Gly Ile Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile Ile 
        595                 600                 605             


Asp Met Val Val Ser Glu Gly Lys Lys Arg Lys Ile Thr Ser Phe Tyr 
    610                 615                 620                 


Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Gly Asp Pro Asp Lys 
625                 630                 635                 640 


Lys Gln Leu Phe Ile His Ile Val Thr Lys Glu Leu Lys Leu Asn Asp 
                645                 650                 655     


Pro Gly Gly His Pro Phe Leu Asp Lys Leu Asp Leu Gln Lys Ile Asn 
            660                 665                 670         


Ser Thr Thr Gly Phe Tyr Glu Ile Tyr Leu Gln Glu Lys Gly His Lys 
        675                 680                 685             


Met Val Pro Glu Asn Asn Pro Lys Thr Gly Lys Val Ile Tyr Thr Asp 
    690                 695                 700                 


His Ser Trp Met Ala Leu Thr Phe Tyr Lys Ile Glu Phe Asn Asp Lys 
705                 710                 715                 720 


Val Asp Met Leu Met Thr Val Val Lys Leu Pro Leu Lys Lys Leu Asn 
                725                 730                 735     


Ile Pro Phe Thr Leu Arg Gln Leu Ser Gly Lys Thr Asn Asn Thr Leu 
            740                 745                 750         


Lys Gln Trp Leu Asn Asn Leu Thr Gln Gly Lys Lys Arg Asn Asp Gly 
        755                 760                 765             


Lys Arg Pro Ile Asn Leu Pro Thr Asn Leu Phe Asp Glu Arg Leu Ala 
    770                 775                 780                 


Glu Leu Leu Arg Lys Asp Leu Asp Asn Lys Lys Ile Val Tyr Trp Pro 
785                 790                 795                 800 


Tyr Ala Asn Trp Asn Glu Leu Phe Lys Thr Trp Trp Ser Ser Arg Asn 
                805                 810                 815     


Asp Gly Leu Gln Ser Phe Tyr Asn Ala Glu Arg Glu Tyr Arg Ile Phe 
            820                 825                 830         


Asp Glu Lys Val Asn Phe Tyr Pro Asn Arg Lys Glu Asn Phe Ala Asp 
        835                 840                 845             


Tyr Tyr Gln His Ala Leu Lys Leu Ala Phe Gln Lys Lys Arg Ser Lys 
    850                 855                 860                 


Arg Ile Leu Glu Gln Met Tyr Asp Gln His Leu Pro Asp Ile Leu Phe 
865                 870                 875                 880 


Asp Gln Val Glu Lys Thr Phe Arg His Thr Ile Ala Glu Thr Glu Lys 
                885                 890                 895     


Glu Ile Arg Ile Leu Gln Glu Glu Asp His Ile Met Leu Leu Met Leu 
            900                 905                 910         


Glu Ser Leu Leu Asp Asp Gly Ser Lys Gln Gln Leu Lys Leu Ser Glu 
        915                 920                 925             


Ile Arg Thr His Leu Asn Arg Thr Thr Asn Ile Arg Gln Val Val Lys 
    930                 935                 940                 


Gly Lys Leu Ser Phe Asp Asp Ser Gly Glu Leu Ile Lys Asp Asn Thr 
945                 950                 955                 960 


Asn Ser Glu Ile Val Arg Thr Val Ser Val Thr Asp Gln Leu Lys Lys 
                965                 970                 975     


Phe His Leu Arg Pro Arg Phe Ile Ser Asp Ser Arg Leu Pro Glu Leu 
            980                 985                 990         


Phe Glu Tyr Phe Pro Asp Lys Glu  Ile Gln Met Glu Ser  Leu Lys Asn 
        995                 1000                 1005             


Glu Phe  Asp Thr Tyr 
    1010             


<210>  1480
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1480

Met Glu Thr Lys Gln Gln Val Gly Lys Gly Ile Ser Tyr Asp His Arg 
1               5                   10                  15      


Arg Pro Asp Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asp Gly Val Ile Gln Glu Phe Ala Met Arg Leu Asn Arg 
        35                  40                  45              


Glu Tyr Asp Pro Glu Asn Lys Asn Gln Ser Leu Phe Ser Tyr Phe Asn 
    50                  55                  60                  


Ile Asn Ala Ser Phe Thr Asp Trp Glu Arg Gly Val Asn Ile Leu Lys 
65                  70                  75                  80  


Glu Tyr Trp Pro Met Met Glu Phe Ile Asp Arg Pro Ala Thr Asp Lys 
                85                  90                  95      


Gln Phe Glu Ala Glu Lys Pro Glu Asn Arg Glu Ala Ala Lys Arg Lys 
            100                 105                 110         


Tyr Phe Leu Ala Thr Leu Gly Ala Leu Leu Thr Ser Ile Lys Asp Leu 
        115                 120                 125             


Arg His Tyr Tyr Thr His Tyr Tyr His Pro Pro Val His Leu Asn Asp 
    130                 135                 140                 


Asp Leu Phe Leu Phe Leu Asp His Ala Leu Leu Tyr Thr Ala Phe Asp 
145                 150                 155                 160 


Val Lys Lys Thr Lys Met Lys Asp Asp Lys Thr Arg Gln Leu Leu Asn 
                165                 170                 175     


Gln Asn Leu Ser Leu Glu Leu Glu Lys Leu Lys Lys Leu Lys Val Glu 
            180                 185                 190         


Glu Leu Lys Lys Lys Lys Glu Lys Gly Ile Lys Val Asn Leu Gln Asp 
        195                 200                 205             


Glu Lys Gly Ile Leu Asn Ala Ile Tyr Asn Asp Ala Phe Ala His Ile 
    210                 215                 220                 


Ile Thr Lys Glu Lys Asp Ser Asp Lys Asp Lys Leu Glu Thr Arg Tyr 
225                 230                 235                 240 


Lys Ser Ile Leu Pro Gln Asp Glu Ala Ala Glu Thr Gly Ile Asn Ile 
                245                 250                 255     


Ser Ile Ser Gly Leu Ile Phe Leu Leu Ser Leu Phe Leu Ser Arg Lys 
            260                 265                 270         


Glu Ile Glu Gln Leu Lys Ser Asn Ile Glu Gly Tyr Lys Gly Lys Val 
        275                 280                 285             


Leu Asn Ile Glu Thr Glu Val Asp Arg Lys His Asn Ser Leu Lys Tyr 
    290                 295                 300                 


Met Ala Thr His Trp Val Phe Ser Ile Leu Ala Phe Lys Gly Leu Lys 
305                 310                 315                 320 


Gln Arg Leu Thr Asn Ser Phe Glu Lys Glu Ser Leu Leu Ile Gln Met 
                325                 330                 335     


Met Asp Glu Leu Asn Lys Val Pro Asp Glu Leu Tyr Gln Thr Leu Ser 
            340                 345                 350         


Glu Thr Ala Lys Lys Glu Phe Leu Glu Asp Ile Asn Glu Tyr Val Ser 
        355                 360                 365             


Glu Gly Asp Asp Asn Glu Lys Ala Thr Tyr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Ser Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gln Phe Pro Thr Leu Lys Phe Gln Ile Phe Val Gly 
                405                 410                 415     


Gln Tyr Leu His Asp Asn Arg Pro Lys Thr Leu Ala Ser Asn Gly Met 
            420                 425                 430         


Thr Ala Gln Arg Met Ile Lys Glu Lys Ile Asn Leu Phe Gly Asn Leu 
        435                 440                 445             


Ser Glu Val Thr Lys His Lys Ser Asp Phe Phe Glu Lys Glu Ser Ala 
    450                 455                 460                 


Ala Gln Gly Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Trp Ala Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Val Tyr Ile Asp Met Ile Gly Lys Glu Gly Lys Ala 
                485                 490                 495     


Lys Glu Ile Gln Val Gln Ile Asn Lys Tyr Arg Lys Gln Leu Asn Pro 
            500                 505                 510         


Ala Pro Gln Arg Asp Lys Arg Ile Ser Lys Lys Glu Ile Ile Glu Gln 
        515                 520                 525             


Leu Tyr Lys Glu Lys Val Val Tyr Gly Asp Pro Thr Leu Met Leu Ser 
    530                 535                 540                 


Ala Asn Glu Leu Met Ala Leu Leu Tyr Glu Leu Ile Val Asn Gly Lys 
545                 550                 555                 560 


Ser Gly Ala Glu Leu Glu Asn Lys Ile Val Glu Gln Ile Ile Ala Arg 
                565                 570                 575     


Tyr Glu Gln Ile Glu Ala Tyr Asp Pro Thr Thr Gln Gln Leu Pro Thr 
            580                 585                 590         


Asn Gln Met Pro His Lys Leu Gln Lys Ser Arg Lys Asp Ser Lys Val 
        595                 600                 605             


Thr Asp Thr Asp Lys Leu Leu Lys Thr Ile Asp Lys Glu Ile Asp Glu 
    610                 615                 620                 


Gly Asn Lys Lys Leu Glu Leu Ile Ala Cys His Arg Lys Glu Trp Glu 
625                 630                 635                 640 


Glu Ala Glu Gln Arg Lys Lys Ser Gly Lys Arg Asn Asn Pro Gly Thr 
                645                 650                 655     


Lys Ser Arg Lys His Leu Phe Tyr Ala Ser Glu Met Gly Glu Glu Ala 
            660                 665                 670         


Thr Trp Ile Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Pro Ala Arg 
        675                 680                 685             


Ala Glu Trp Lys Gly Thr His His Ser Glu Leu Gln Arg Leu Leu Ala 
    690                 695                 700                 


Phe Tyr Ser Thr Gln Arg Leu Glu Ala Trp Gln Leu Val Glu Ser Val 
705                 710                 715                 720 


Trp Thr Ala Asn Thr His Ser Phe Trp Glu Glu Asn Phe Lys Glu Ala 
                725                 730                 735     


Phe Tyr Lys Pro Glu Phe Glu Asn Phe Tyr Gly Ala Tyr Ile Glu Ile 
            740                 745                 750         


Arg Thr Lys Ile Leu Thr Thr Cys Arg Ser Ile Leu Glu Asn Asn Pro 
        755                 760                 765             


Glu Ala Thr Met Asn Asn Asp Thr Glu Lys Glu Trp Asp Lys Val Phe 
    770                 775                 780                 


Thr Leu Phe Asp Lys Arg Leu Tyr Arg Thr Ser Thr Thr Asp Glu Gln 
785                 790                 795                 800 


Lys Lys Gln Leu Leu Thr Lys Pro Phe Ala Phe Pro Arg Gly Leu Phe 
                805                 810                 815     


Asp Asp Lys Pro Thr Phe Leu Pro Gly Ser Lys Pro Asn Glu Asn Pro 
            820                 825                 830         


Glu Arg Phe Ala Ala Trp Tyr Ser Tyr Gly Tyr Thr Tyr Ser Gly Lys 
        835                 840                 845             


Phe Gln Ser Phe Tyr Asp Met Pro Arg Asn Tyr Ser Asp Trp Tyr Lys 
    850                 855                 860                 


Lys Leu Lys Glu Asp Gly Lys Leu Pro Arg Leu Asp Lys Lys Thr Glu 
865                 870                 875                 880 


Gln Glu Lys Ile Leu Arg Phe Arg Met Asp Cys Asp Leu Asn Ile Lys 
                885                 890                 895     


His Ile Arg Phe Gln Asp Ile Tyr Val Lys Leu Met Val Asp Ser Leu 
            900                 905                 910         


Tyr Lys Ala Val Phe Gly Gln Gln Pro Glu Phe Asp Leu Ser His Leu 
        915                 920                 925             


Tyr Asp Thr Arg Ser Glu Arg Tyr Glu Asn Asn Thr Ile Ala Gln Arg 
    930                 935                 940                 


Gln Lys Ser Arg Gln Glu Gly Asp Asn Ser Asp Asn Ala Ile Asn Glu 
945                 950                 955                 960 


Asn Tyr Val Trp Asn Lys Thr Phe Ala Ile Ser Leu Tyr Asn Gly Arg 
                965                 970                 975     


Ile Thr Glu Ser Gln Val Lys Leu Lys Asp Val Gly Lys Phe Arg Arg 
            980                 985                 990         


Phe Ala Thr Asp Pro Arg Val Gln  Thr Leu Ile Ser Tyr  Asp Asp Thr 
        995                 1000                 1005             


Arg Thr  Trp Thr Lys Leu Glu  Ile Glu Asn Glu Leu  Asp Asn Lys 
    1010                 1015                 1020             


Ala Asp  Ala Tyr Glu Pro Ile  Arg Arg Thr Gln Ser  Leu Lys Ala 
    1025                 1030                 1035             


Ile Gln  Gln Leu Glu Lys Asn  Ile Leu Lys Lys Asn  Gly Phe Asn 
    1040                 1045                 1050             


Gly Lys  Gln His Pro Glu Glu  Leu Lys His Asn Gly  Asn Pro Asn 
    1055                 1060                 1065             


Phe Arg  Lys Tyr Ile Ala Asn  Gly Leu Leu Lys His  Arg Thr Asp 
    1070                 1075                 1080             


Ile Arg  Gln Glu Glu Leu Ala  Leu Ile Ser Asp Thr  Glu Phe Gln 
    1085                 1090                 1095             


Glu Ile  Gly Leu Glu Arg Ile  Arg Gln Thr Asn Pro  Leu Ile Gln 
    1100                 1105                 1110             


Lys Ala  Tyr Leu Leu Ile Leu  Leu Arg Asn Lys Phe  Gly His Asn 
    1115                 1120                 1125             


Gln Leu  Pro Asp Gln Glu His  Phe Arg Leu Met Arg  Ser Ile Tyr 
    1130                 1135                 1140             


Pro Tyr  Asn Gln Gln Glu Ser  Tyr Ser Ala Tyr Phe  Asn His Val 
    1145                 1150                 1155             


Ile Thr  Gln Ile Ile Glu Glu  Leu Asn Thr 
    1160                 1165             


<210>  1481
<211>  1129
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1481

Met Glu Thr Asn Gln Gln Thr His Glu Asn Arg Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Asn Asn His Val Ala Thr Asp Phe Lys Arg Lys Pro 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Asp Ala Leu Leu Cys Asn Lys Thr 
    50                  55                  60                  


Ile Lys Asn Leu Asn Trp Asn His Val His Thr Arg Ala Leu Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ser Glu Ser Leu Pro Lys Asp Glu 
                85                  90                  95      


Arg Lys Asn Ser Asp Thr Glu Gly Lys Asp Phe Thr Ser Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Ser Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Asp Ser Arg Lys Leu Ile Val 
    130                 135                 140                 


Ser Pro Glu Leu Ala Asn Phe Leu Thr Ile Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Thr Tyr Thr Lys Ala Arg Met Lys Asp Val Leu Thr Asp Ala Asp Tyr 
                165                 170                 175     


Ala Leu Val Glu Asn Leu Gln Met Val Ala Thr Asp Asn Lys Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ala Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asn Gln Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Ser 
            260                 265                 270         


Ile Ile Thr Asp Lys Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Glu Asn Leu Ile Ala Asn Ser Thr Asn Asn Glu Glu Arg 
    290                 295                 300                 


Glu Arg Ile Leu Asp Glu Ile Asp Tyr Gln Asp Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg Tyr Asn Asn Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Asp Glu Lys Asn Ile Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Asn Tyr Thr Lys Gln Phe Ala Gly Glu 
        355                 360                 365             


Gln Ala Glu Arg Lys Val Leu Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asp Pro Glu Leu Ser Gln Gln Arg Ile Asp Lys Gln 
385                 390                 395                 400 


Gln Gln Thr Ala Gly Phe Glu Gln Phe Ala Pro Arg Tyr His Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Asn Ile Ala Thr Leu Thr 
            420                 425                 430         


Ala Lys Ser Lys Ala Gly Ser Lys Val Glu His Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Gln Ala Glu Glu Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Ile Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Ser Gln Leu Pro Asp Gly Trp Asn Glu Phe Asn Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asp Ser Thr Leu Arg Tyr Leu 
        515                 520                 525             


His Gln Arg Lys Thr Ile Leu Asn Thr Ile Leu Ser Lys Tyr Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Lys Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Thr Arg Leu Lys Ala Val Glu Lys His Lys Leu 
            580                 585                 590         


Asn Lys Ser Val Lys Ile Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Glu Glu Lys Lys Lys Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Thr Asn Ala Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Asn Asp Gly His Pro Phe Leu Gln Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Gln Ala Tyr Leu Ile 
        675                 680                 685             


Glu Lys Gly Asn Lys Met Val Pro Arg Leu Asn Pro Lys Thr Asn Lys 
    690                 695                 700                 


Thr Ser Lys Val Asp Glu Ser Trp Met Met Lys Gln Phe Tyr Val Lys 
705                 710                 715                 720 


Glu Trp Lys Glu Glu Ile Ala Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Ser Arg Ile Pro Phe Thr Ile Arg Gln Trp Asp Glu Lys 
            740                 745                 750         


Glu Lys Tyr Asp Leu Asn Thr Trp Leu Arg His Val Thr Val Gly Lys 
        755                 760                 765             


Asn Asn Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe Asp 
    770                 775                 780                 


Glu Ala Leu Cys Asp Leu Leu Arg Glu Gln Leu Asp Thr Lys Ile Val 
785                 790                 795                 800 


Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Ile Trp Trp 
                805                 810                 815     


Lys Thr Arg Asn Asp Asp Thr Gln Gln Phe Tyr Gln Ser Glu Arg Glu 
            820                 825                 830         


Tyr Asn Ile Tyr Asn Glu Lys Val Arg Phe Lys Ile Asp Ser Ser Ala 
        835                 840                 845             


His Phe Ala Asp Tyr Tyr Lys Asn Ala Leu Ser Arg Ala Phe Thr Arg 
    850                 855                 860                 


Leu Lys Ala Glu Arg Glu Thr Ala Arg Gln Ser Asn Lys Arg Leu Pro 
865                 870                 875                 880 


Pro Leu Glu Tyr Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile Ala 
                885                 890                 895     


Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met Ala 
            900                 905                 910         


Val Leu Met Leu Glu Arg Leu Met Asp Asn Ser Pro Asn Leu Arg Leu 
        915                 920                 925             


Ser Lys Ile Glu Thr Leu Leu Asn Asp Thr Thr Pro Ile Arg Glu Lys 
    930                 935                 940                 


Ile Ser Ala Thr Leu Ser Phe Asp Ala Ser Gly Glu Arg Ile Ser Gly 
945                 950                 955                 960 


Lys Ser Asn Pro Thr Val Thr Lys Thr Leu Val Ala Glu Arg Lys Gln 
                965                 970                 975     


Lys Asn Tyr Thr Glu Leu Arg Lys Tyr Arg Tyr Asp Arg Arg Leu Pro 
            980                 985                 990         


Glu Leu Phe Glu Tyr Val Gln Ala  Asp Glu Ile Pro Leu  Glu Trp Leu 
        995                 1000                 1005             


Leu Glu  Glu Leu Ser Ala Tyr  Asn Asn Ala Lys Gln  Gln Val Phe 
    1010                 1015                 1020             


Asp Thr  Val Phe Thr Leu Glu  Lys Lys Ile Ile Gly  Thr Asp Pro 
    1025                 1030                 1035             


Asp Gly  Leu Lys Ser Leu Phe  Thr Gly Ala Asn Gly  Glu Leu Gln 
    1040                 1045                 1050             


Thr Gly  Asn Ile Gln His Lys  Pro Tyr Val Gln Trp  Leu Thr Asn 
    1055                 1060                 1065             


Lys Gly  Leu Ile Asn Lys Glu  Glu Lys Gln Phe Ile  Asn Met Val 
    1070                 1075                 1080             


Arg Lys  Cys Phe Ser His Asn  Gln Phe Pro Gln Arg  Lys Thr Met 
    1085                 1090                 1095             


Glu Leu  Leu Ile Pro Ala Trp  Asn Glu Lys Lys Leu  Ala Leu Gln 
    1100                 1105                 1110             


Ile Ala  Thr Val Tyr Asn Gln  Leu Ile Ala Asp Leu  Thr Asn Lys 
    1115                 1120                 1125             


Ile 
    


<210>  1482
<211>  1140
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1482

Met Glu Asn Asp Gln Gln Ile Leu Glu Asn Arg Arg Arg Thr Leu Ala 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Ser Asn His Leu Ala Ala Ser Phe Glu Gln Lys Val 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ala Ser Phe Leu Cys Asn Lys Ser 
    50                  55                  60                  


Ile Lys Lys Ile Asn Trp Asn His Val Tyr Ser Lys Ala Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ala Asp Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Arg Glu Thr Thr Asp Lys Glu Gly Lys Asp Phe Thr Ala Met Asn Glu 
            100                 105                 110         


Thr Leu Lys Leu Val Phe Asp Glu Leu Gln Ala Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Ala Asp Ser Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Val Glu Leu Ala Asp Phe Leu Thr Val Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Ala Asp Asp Asp Tyr 
                165                 170                 175     


Thr Met Val Glu Ser Lys Gln Ile Val Thr Pro Asp Asn Leu Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Val Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Leu Ala Tyr Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asp Leu Gly Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Glu 
            260                 265                 270         


Val Ile Thr Glu Glu Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Glu Glu Glu Arg 
    290                 295                 300                 


Glu Lys Ile Leu Asp Glu Ile Asp Tyr Glu Asp Tyr Ile Glu Ser Leu 
305                 310                 315                 320 


Thr Arg Arg Val Arg His Ser Asn Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Lys Tyr Asn Lys Gln Phe Asp Gly Glu 
        355                 360                 365             


Ala Thr Glu Cys Lys Val Val Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asn Gln Glu Thr Val Glu Leu Lys Ile Asp Ser Ala 
385                 390                 395                 400 


Gln Arg Thr Asn Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Glu Ala Arg Leu Leu 
            420                 425                 430         


Thr Lys Ala Lys Pro Glu Ser Lys Val Ser Tyr Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Lys Ala Glu Glu Met Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Lys Val Asn Asp Ser Gln Leu Met Ser Met Gln Phe Ile Asp Glu 
                485                 490                 495     


Ile Lys Glu Gln Leu Pro Ala Asp Trp Asn Glu Phe Gly Lys Arg Ser 
            500                 505                 510         


Asp Ser Lys Lys Lys Lys Ala Tyr Thr Asn Ala Ala Leu Gln Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Lys Val Leu Ala Asn Tyr Gln Leu 
    530                 535                 540                 


Asn Asp Lys Gln Val Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Ser Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Val Glu Lys His Lys Leu 
            580                 585                 590         


Asp Lys Ser Ala Arg Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Thr Asp Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Phe Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Tyr 
625                 630                 635                 640 


Ala Asp Thr Asp Lys Lys Ala Thr Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Lys Gly Gly His Pro Phe Leu Ala Asn Ile Asn 
            660                 665                 670         


Leu Arg Gln Ile Arg Lys Thr Ser Gln Leu Tyr Glu Leu Tyr Leu Val 
        675                 680                 685             


Glu Lys Ala Asn Lys Gln Val Lys Lys Met Asn Pro Lys Thr Gln Arg 
    690                 695                 700                 


Thr Ser Asn Val Asp Glu Ser Trp Met Met Lys Ser Phe Tyr Ala Lys 
705                 710                 715                 720 


Glu Trp Asn Glu Glu Met Gly Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Val Asn Lys Thr Asn Ile Pro Phe Thr Ile Arg Gln Trp Glu Glu Lys 
            740                 745                 750         


Glu Lys His Asn Leu Gln Ala Trp Leu His Asn Ile Thr Lys Gly Lys 
        755                 760                 765             


Thr Ser Lys Asp Gly Lys Lys Ala Ile Asp Leu Pro Thr Asn Leu Phe 
    770                 775                 780                 


Asp Asp Thr Leu Cys Glu Leu Leu Arg Glu Ala Leu Ile Asn Gln Gly 
785                 790                 795                 800 


Ile Asp Ala Thr Pro Thr Thr Lys Tyr Asn Glu Leu Leu Lys Gln Trp 
                805                 810                 815     


Trp Thr Ala Arg Glu Asp Ser Thr Gln Asp Phe Tyr Leu Ser Glu Arg 
            820                 825                 830         


Gln Tyr Asp Ile Tyr Asp Glu Lys Val Cys Phe Thr Ile Asn Ser Ser 
        835                 840                 845             


Ala His Phe Ala Asp Tyr Tyr Ala Pro Ala Leu Asn Lys Ala Tyr Ser 
    850                 855                 860                 


Arg Leu Arg Ala Glu Arg Asp Val Ala Arg Arg Thr Asp Lys Arg Leu 
865                 870                 875                 880 


Pro Pro Val Glu Arg Lys Asp Val Glu Arg Val Phe Lys Asn Thr Ile 
                885                 890                 895     


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
            900                 905                 910         


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asn Gln Gln Gln Leu Lys 
        915                 920                 925             


Leu Ser Lys Met Asp Ser Leu Leu Asn Glu Thr Lys Arg Ile Glu Gln 
    930                 935                 940                 


Thr Ile Asn Thr Gln Leu Ser Phe Asp His Lys Gly Lys Glu Ile Lys 
945                 950                 955                 960 


Asp Lys Thr Asn Ser Glu Ile Val Lys Thr Ile Val Ala Glu Arg Lys 
                965                 970                 975     


Gln Lys Asn Tyr Thr Glu Met Arg Lys Tyr Val His Asp Arg Arg Leu 
            980                 985                 990         


Pro Glu Leu Phe Glu Tyr Ile Asp  Gly Asn Glu Leu Pro  Leu Asp Val 
        995                 1000                 1005             


Leu Leu  Asn Glu Leu Arg Ala  Tyr Asn Thr Ala Lys  Gln Met Val 
    1010                 1015                 1020             


Phe Asp  Thr Val Phe Ala Leu  Glu Lys Lys Ile Ile  Glu Thr Asp 
    1025                 1030                 1035             


Pro Glu  Gly Leu Lys Gln Leu  Asn Val Gly Lys Asn  Gly Gln Ile 
    1040                 1045                 1050             


Gln Thr  Gly Asn Ile Gln His  Lys Pro Tyr Val Gln  Trp Leu Glu 
    1055                 1060                 1065             


Asn Lys  Gly Leu Ile Thr Asp  His Gln Lys Gln Phe  Ile Asn Met 
    1070                 1075                 1080             


Val Arg  Asn Ser Phe Ser His  Asn Gln Phe Pro Gln  Arg Ser Thr 
    1085                 1090                 1095             


Val Glu  Leu Leu Met Pro Glu  Trp Gln Asn Thr Asp  Ile Ala Leu 
    1100                 1105                 1110             


Gln Ile  Ala Arg Glu Tyr Gln  Gln Leu Ile Val Asp  Ile Ile Glu 
    1115                 1120                 1125             


Lys Ser  Leu His Pro His Lys  Gln His Gln Met Val  
    1130                 1135                 1140 


<210>  1483
<211>  1119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1483

Met Thr Glu Gln Asn Glu Arg Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Thr His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Tyr Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Gly Thr Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Thr Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Cys Glu Glu Asp Arg Ala Cys Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Ala 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Leu Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Asp Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Gly Glu Ile Asp Thr Leu Asp 
    530                 535                 540                 


Arg Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Ser Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly His Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Asp Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Leu Ala Lys Leu Lys Lys Glu Ile Leu Glu Ala 
        835                 840                 845             


Lys Glu His Pro Tyr Leu Asp Phe Lys Ser Trp Gln Lys Phe Glu Arg 
    850                 855                 860                 


Glu Leu Arg Leu Val Lys Asn Gln Asp Ile Ile Thr Trp Met Met Cys 
865                 870                 875                 880 


Arg Asp Leu Met Glu Glu Asn Lys Val Glu Gly Leu Asp Thr Gly Thr 
                885                 890                 895     


Leu Tyr Leu Lys Asp Ile Arg Thr Asp Val Tyr Glu Gln Gly Ser Leu 
            900                 905                 910         


Asn Val Leu Asn Arg Val Lys Pro Met Arg Leu Pro Val Val Val Tyr 
        915                 920                 925             


Arg Ala Asp Ser Arg Gly His Val His Lys Glu Gln Ala Pro Leu Ala 
    930                 935                 940                 


Thr Val Tyr Ile Glu Glu Arg Asp Thr Lys Leu Leu Lys Gln Gly Asn 
945                 950                 955                 960 


Phe Lys Ser Phe Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe 
                965                 970                 975     


Val Asp Thr Gly Gly Leu Ala Met Glu Gln Tyr Pro Ile Ser Lys Leu 
            980                 985                 990         


Arg Val Glu Tyr Glu Leu Ala Lys  Tyr Gln Thr Ala Arg  Val Cys Ala 
        995                 1000                 1005             


Phe Glu  Gln Thr Leu Glu Leu  Glu Glu Ser Leu Leu  Thr Arg Tyr 
    1010                 1015                 1020             


Pro His  Leu Pro Asp Glu Ser  Phe Arg Glu Met Leu  Glu Ser Trp 
    1025                 1030                 1035             


Ser Asp  Pro Leu Leu Asp Lys  Trp Pro Asp Leu His  Arg Lys Val 
    1040                 1045                 1050             


Arg Leu  Leu Ile Ala Val Arg  Asn Ala Phe Ser His  Asn Gln Tyr 
    1055                 1060                 1065             


Pro Met  Tyr Asp Glu Ala Val  Phe Ser Ser Ile Arg  Lys Tyr Asp 
    1070                 1075                 1080             


Pro Ser  Ser Pro Asp Ala Ile  Glu Glu Arg Met Gly  Leu Asn Ile 
    1085                 1090                 1095             


Ala His  Arg Leu Ser Glu Glu  Val Lys Gln Ala Lys  Glu Met Ala 
    1100                 1105                 1110             


Glu Arg  Ile Ile Gln Ala 
    1115                 


<210>  1484
<211>  1199
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1484

Met Asn Thr Phe Ile Asp Ser Phe Ile Arg Arg Val Gln Ile Gln Asn 
1               5                   10                  15      


Gln Asn Gln Ser Trp Pro Lys Arg Pro Lys Tyr Val Arg Pro Val Glu 
            20                  25                  30          


Asn Ile Arg Pro Asp Asp Leu Ala Phe Gln Ser His Phe Thr Ala Tyr 
        35                  40                  45              


Leu Asn Met Ala Arg Gln Asn Cys Cys Ile Ile Leu Gly His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Gly Phe Lys Ala Ser Ser Val Lys Asp Thr Thr Leu Thr 
65                  70                  75                  80  


Ser Ser Pro Leu Leu Gly Gln Asn Gly Leu Leu Ser Pro Lys Lys Glu 
                85                  90                  95      


Val Ser Asp Leu Ile Arg Gly Arg Leu Leu Ser Ala Phe Pro Met Leu 
            100                 105                 110         


Asp Pro Met Ile Arg Tyr Arg Lys Ala Val Asp Lys Glu Lys Asp Asp 
        115                 120                 125             


Tyr Ala Arg Ile Ile Ile Thr Ser Glu Asp Val Ser Glu Met Leu Arg 
    130                 135                 140                 


Asp Leu Leu Asp Val Leu Ser Tyr Tyr Arg Asp Met Ala Ser His Val 
145                 150                 155                 160 


Val Phe Asn Asp Asp Arg Ser Val Ser Ala Glu Phe Ala Ser Lys Glu 
                165                 170                 175     


Lys Lys Val Ala Glu Cys Leu Asn Tyr Met Met Thr Val Ser Leu Arg 
            180                 185                 190         


Ile Val Lys Asp Arg Phe Ser Leu Ala Val Ser Asp Leu Asp Phe Tyr 
        195                 200                 205             


Asn Arg Asn Arg Tyr Met Met Val Asn Arg Lys Pro Leu Leu Asn Ala 
    210                 215                 220                 


Gly Phe Ala His Ala Val Arg Thr Glu Asp Tyr Arg Leu Thr Leu Met 
225                 230                 235                 240 


Gly Leu Val Leu Leu Cys Cys Gln Phe Ile Glu Lys Gln Tyr Ala Ser 
                245                 250                 255     


Met Phe Phe Asp Ala Leu Asp Lys His Ser Asn Gly Ala Arg Phe Tyr 
            260                 265                 270         


Gly Ile Ala Asp Ala Met Pro Met Val Asn Val Gly Thr Lys Asp Lys 
        275                 280                 285             


Pro Lys Lys Ile Pro Met Tyr Thr Gly Asp Glu Ala Gln Lys Gln Val 
    290                 295                 300                 


Gln Lys Gln Arg Met Ala Leu Arg Glu Ala Tyr Ser Val Tyr Arg Val 
305                 310                 315                 320 


Arg Ile Pro Lys Glu Arg Leu Glu Ser Thr Arg Ser Asp Met Ala Leu 
                325                 330                 335     


Ala Leu Asp Ile Leu Asn Glu Leu Gly Lys Cys Pro Glu Glu Leu Phe 
            340                 345                 350         


Glu His Leu Ser Pro Glu Asp Arg Glu Ser Phe Lys Asn Glu Glu Gly 
        355                 360                 365             


Val Leu Met Lys Arg Tyr Ser Asp Arg Phe Pro Gln Leu Ala Leu Arg 
    370                 375                 380                 


Trp Leu Asp Glu Asn Glu Lys Phe Asn Asn Leu Arg Phe His Val Thr 
385                 390                 395                 400 


Phe Gly Lys Tyr Arg Trp Leu Phe Cys Gln Asp Lys Lys Cys Ala Asp 
                405                 410                 415     


Gly Ser Val Arg Pro Arg Trp Leu Gln Lys Glu Leu Asn Gly Phe Gly 
            420                 425                 430         


Arg Ile Gln Thr Val Glu Arg Lys Arg Thr Gly Leu Glu Pro Gly Trp 
        435                 440                 445             


Asp Gly Thr Gly Leu Ile Arg Lys Phe Glu Glu Val Val Thr Asp Glu 
    450                 455                 460                 


Val Gln Lys Glu Pro Tyr Ile Thr Asp Phe Arg Thr Gln Tyr Leu Phe 
465                 470                 475                 480 


Asn Arg Asp Lys Ile Gly Ile Ser Leu Ser Glu Tyr Met Pro Gly Ile 
                485                 490                 495     


Gly Asp Ile His Ser Gly Lys Glu Trp Gly Lys His Ala Gly Val Pro 
            500                 505                 510         


Asp Phe Tyr Leu Ser Val Tyr Asp Ile Pro Ala Met Leu Phe Leu Thr 
        515                 520                 525             


Trp Leu Leu Gly Lys Asn Ser Ser Ala Val Glu Lys Leu Leu Ala Asn 
    530                 535                 540                 


Cys Lys Ala Ala Tyr Met Lys Leu Phe Asp Asp Leu Ala Lys Gly Lys 
545                 550                 555                 560 


Trp Glu Gly Glu Arg Asn Val Ser Asp Tyr Cys Ala Gly Glu Gly Thr 
                565                 570                 575     


Val Arg Tyr Thr Leu Arg Trp Tyr Asp Val Pro Met Lys Ile Arg Arg 
            580                 585                 590         


Lys Met Pro Leu Leu Gly Gly Asp Arg Asp Phe Glu Glu Lys Lys Ser 
        595                 600                 605             


Phe Glu Thr Leu Ala Gln Glu Ala Leu Thr Arg Met Leu Gln Arg Thr 
    610                 615                 620                 


Glu Asn Gln Leu Glu Lys Phe Asp Arg Asp Leu Ala Ala Ala Arg Asp 
625                 630                 635                 640 


Leu Lys Ala Asn Lys Gln Gly Lys Asp Arg Phe Val Asp Ile Arg Ala 
                645                 650                 655     


Gly Ser Leu Ala Thr Phe Leu Ala Arg Asp Ile Val Arg Leu Met Pro 
            660                 665                 670         


Val Ser Asp Asn Gly Arg Asn Lys Pro Thr Gly Leu Asn Tyr Ser Ile 
        675                 680                 685             


Val Gln Lys Ala Ile Ala Thr Tyr Lys Pro Ser Glu Gly Gly Leu Asp 
    690                 695                 700                 


Thr Leu Thr Gly Val Phe Arg Asp Ala Arg Ile Ile Gly Val Lys Gly 
705                 710                 715                 720 


Gly Ser His Pro Phe Leu Glu Arg Leu Leu Val Glu Lys Lys Pro Ser 
                725                 730                 735     


Ser Val Leu Ala Leu Tyr Arg His Tyr Leu Glu Tyr Arg Lys Glu Tyr 
            740                 745                 750         


Leu Lys Lys Ala Leu Glu Asp Glu Asn Lys Ala Glu Leu Lys Asn Leu 
        755                 760                 765             


Pro Phe Leu Lys Ser Gly Arg Gln Lys Tyr Ala Val Asp Gln Ala Asp 
    770                 775                 780                 


Tyr Ala Arg Arg Leu Ala Glu Ser Tyr Arg Asn Cys Pro Ile Tyr Leu 
785                 790                 795                 800 


Pro Thr Gly Ile Phe Thr Asp Met Leu Lys Asp Gln Leu Ala Lys Ile 
                805                 810                 815     


Asp Val Met Lys Pro Val Leu Glu Asn Asp Lys Val Asn Ala Ser Tyr 
            820                 825                 830         


Leu Ile Ala Gln Tyr Phe Glu Lys Val Glu His Asp Ser Glu Gln Pro 
        835                 840                 845             


Leu Tyr Arg Leu Lys Arg Asn Tyr Arg Val Phe Asp Leu Leu Glu Phe 
    850                 855                 860                 


Thr Asp Glu Pro Lys Tyr Trp Arg Leu Asn Glu Arg Ser Asp Lys Ala 
865                 870                 875                 880 


Gly Lys Tyr Gly Leu Ala Lys Arg Asn Ile Phe Trp Asn Arg Met Gly 
                885                 890                 895     


Glu Tyr Tyr Lys Gly Leu Lys Lys Phe Tyr Lys Gly Tyr Glu Ser Lys 
            900                 905                 910         


Arg Thr Ala Val Asp Trp Arg Glu Lys Leu Lys Ile Val Glu Ala Glu 
        915                 920                 925             


His Ala Met Trp Asn Arg Leu Lys Asp Ala Ser Gly Glu Ala Arg Leu 
    930                 935                 940                 


Lys Met Lys Asp Gly Val Phe Tyr Ser Arg Leu Leu Ser Ala Arg Lys 
945                 950                 955                 960 


Glu Tyr Asp Asp Cys Glu Arg Ala Leu Arg Arg Leu Lys Val Gln Asp 
                965                 970                 975     


Ile Val Leu Phe Leu Ala Ala Arg Glu Thr Leu Ile Leu Pro Lys Asp 
            980                 985                 990         


Lys Val Phe Arg Leu Lys Asn Leu  Ser Leu Ser Glu Gly  Asn Lys Asn 
        995                 1000                 1005             


Ile Leu  Ser Ser Ala Ile Asp  Glu Phe Ser Val Asp  Val Val Trp 
    1010                 1015                 1020             


Thr Glu  Lys Glu Gly Ala Ala  Lys Val Thr His Ser  Ala Ser Ile 
    1025                 1030                 1035             


Lys Glu  Asn Asp Val Val Ile  Lys Asn Tyr Gly Arg  Met Phe Arg 
    1040                 1045                 1050             


Leu Leu  His Asp Asp Arg Val  Lys Thr Leu Leu Pro  His Ile Tyr 
    1055                 1060                 1065             


Asp Ser  Ala Leu Ser Glu Asn  Ile Thr Gly Asp Arg  Ile Thr Val 
    1070                 1075                 1080             


Lys Asp  Asn Lys Val Ile Ile  Asp Lys Ser Leu Phe  Asp Glu Asp 
    1085                 1090                 1095             


Leu Met  Asn Tyr Asp Leu Arg  Arg His Glu Ile Cys  Glu Ile Ile 
    1100                 1105                 1110             


Leu Arg  Phe Glu Ala Ala Ser  Ile Lys Arg Phe Gly  Leu Asp Gly 
    1115                 1120                 1125             


Arg Val  Asp Phe Lys Ala Ala  Leu Asp Ala Leu Thr  Gly Arg Ser 
    1130                 1135                 1140             


Leu Leu  Asn Asp Glu Asp Ala  Arg Ile Leu Ser Ala  Ile Arg Asn 
    1145                 1150                 1155             


Ala Tyr  Asn His Asn Lys Tyr  Pro Ala Lys Gly Thr  Asp Val Lys 
    1160                 1165                 1170             


Val Asn  Val Met Ala Leu Pro  Lys Leu Thr Glu Asp  Leu Leu Arg 
    1175                 1180                 1185             


Ile Phe  Ser Asp Thr Gly Asn  Asn Arg Val Arg 
    1190                 1195                 


<210>  1485
<211>  1057
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1485

Met Thr Ile Lys Glu Gln Ser His Phe Ala Ala Tyr Tyr Asn Met Ala 
1               5                   10                  15      


Arg His Asn Met Tyr Glu Thr Leu Cys Tyr Ile Ser Lys Ile Ser Gly 
            20                  25                  30          


Ile Gln Glu Gly Glu Asp Asn Lys Glu Ser Lys Ile Glu Asp Met Gln 
        35                  40                  45              


Leu Leu Arg Val Leu Thr Thr Lys Gly His Pro Glu Glu Lys Ile Arg 
    50                  55                  60                  


Ile Glu Lys Leu Ile Tyr Lys His Leu Pro Leu Phe Arg Pro Ala Val 
65                  70                  75                  80  


Glu Asp Leu Arg Lys Lys Ser Lys Glu Asn Val Lys Ser Pro Glu Leu 
                85                  90                  95      


Leu Ala Lys Val Ile Lys Asn Trp Ala Lys Val Ile Thr Tyr Tyr Arg 
            100                 105                 110         


Asp Lys Phe Thr His Tyr Val Phe Ile Asp Lys Arg His Glu Asn Lys 
        115                 120                 125             


Glu Phe Leu Asn Ala Glu Met Ser Val Ala Asn Asp Leu Asn Gln Ile 
    130                 135                 140                 


Phe Thr Ala Ser Ala Arg Val Ile Lys Glu Arg Phe Gly Leu Ser Thr 
145                 150                 155                 160 


Glu Leu Glu Phe Leu Thr Lys Gly Arg Tyr Arg Thr Gln Thr Ile Asp 
                165                 170                 175     


Gly Lys Arg Ser Thr Lys Leu Asn Pro Asn Phe Ile Tyr Ser Leu Gln 
            180                 185                 190         


Asp Lys Asn Glu Arg Leu Asn Lys Met Gly Leu Ile Phe Leu Ala Cys 
        195                 200                 205             


Gln Leu Ile Glu Lys Lys Tyr Ala Ser Met Leu Phe Asp Gln Gln Gly 
    210                 215                 220                 


Tyr Met Gly Arg Asp Ile Tyr Phe Asp Phe Thr Pro Ala Gln Cys Lys 
225                 230                 235                 240 


Tyr Ile Arg Glu Val Phe Ser Ala His Arg Ile Val Leu Pro Arg Gly 
                245                 250                 255     


Arg Met Asp Val Glu Arg Asn Glu Ile Thr Ile Ala Met Asp Met Phe 
            260                 265                 270         


Asn Glu Leu Gly Lys Cys Pro Lys Glu Leu Phe Glu Ile Ile Ser Lys 
        275                 280                 285             


Glu Glu Gln Lys Arg Phe Arg Thr Lys Ser Glu Thr Thr Gly Glu Glu 
    290                 295                 300                 


Val Leu Leu Met Arg His Ser Asp Arg Phe Ala Thr Leu Ala Leu Gln 
305                 310                 315                 320 


Tyr Ile Asp Asn Arg Lys Val Phe Glu Lys Ile Arg Phe Gln Leu Ser 
                325                 330                 335     


Leu Gly Lys Tyr Arg Tyr Lys Phe Tyr Asp Lys Thr Cys Val Asp Gly 
            340                 345                 350         


Asp Thr His Val Arg Ile Leu Gln Lys Glu Leu Asn Gly Phe Gly Arg 
        355                 360                 365             


Ile Asn Glu Ile Glu Leu Leu Lys Glu Glu Lys Trp Gly Gly Leu Ile 
    370                 375                 380                 


Arg Lys Phe Glu Asp Ala Lys Ile Asp Thr Ala Glu Thr Lys Pro Tyr 
385                 390                 395                 400 


Ile Thr Asp Gln Tyr Pro Gln Tyr Leu Phe Asn Gly Asn Arg Ile Gly 
                405                 410                 415     


Ile Tyr Phe Asn Ser Ala His Gly Lys Ala Met Arg Asn Gly Ala Tyr 
            420                 425                 430         


Ile Pro Asp Ile Glu Ser Gly Ala His Cys Ile Gln Pro Ile Cys Trp 
        435                 440                 445             


Ile Ser Asn Tyr Glu Leu Pro Ala Leu Ile Phe His His Ile Leu Thr 
    450                 455                 460                 


Lys Asp Glu Lys Lys Ser Leu Thr Glu Lys Ile Ile Ile Asp Cys Val 
465                 470                 475                 480 


Glu Arg Tyr Lys Lys Leu Phe Asn Asp Ile Ala Glu Gly Lys Val Ala 
                485                 490                 495     


Arg Thr Gly Asn Ala Thr Ser Asp Phe Glu Met Ile Ser Lys Glu Tyr 
            500                 505                 510         


Gly Ile Glu Lys Ser Asp Ile Pro Arg Glu Leu Gln Asp Tyr Phe Asn 
        515                 520                 525             


Gly Thr Glu Arg Asp Gly Ile Glu Gln Tyr Ala Lys Ala Gln Ile Arg 
    530                 535                 540                 


Glu Met Ile Glu Glu Asn Arg Ile Arg Leu Glu Gln Phe Asn Ser Lys 
545                 550                 555                 560 


Leu Lys Lys Ile Glu Asp Gly Glu Val Lys Tyr Gly Lys Arg Asp Tyr 
                565                 570                 575     


Thr Glu Ile Arg Thr Gly Glu Leu Ala Gln Tyr Leu Ala Lys Asp Ile 
            580                 585                 590         


Val Met Phe Met Pro Lys Ala Lys Tyr Lys Pro Thr Ser Lys Asn Tyr 
        595                 600                 605             


Asn Val Met Gln Ala Leu Leu Ala Thr Phe Asn Gly Ser Glu Ser Gly 
    610                 615                 620                 


Ser Thr Leu Asp Glu Val Asp Asp Met Phe Asp Asn Ile Lys Ala Cys 
625                 630                 635                 640 


Tyr Trp Lys Asn Glu Ser Asp Asn His Pro Phe Leu Glu Tyr Val Leu 
                645                 650                 655     


Gly Glu Glu Pro Lys Asp Ile Ile Ala Phe Tyr Lys Ile Tyr Leu Glu 
            660                 665                 670         


Leu Arg Gly Glu Tyr Leu Asp Lys Cys Ile Lys Lys Met Asp Leu Ala 
        675                 680                 685             


Thr Ile Pro Phe Ile His Thr Glu Arg Lys Arg Trp Glu Lys Arg Asp 
    690                 695                 700                 


Glu Lys Phe Phe Lys Glu Leu Ala Gln Arg Tyr Ala Thr Gln Pro Ile 
705                 710                 715                 720 


Glu Leu Pro Arg Gly Leu Tyr Asp Arg Ala Ile Lys Glu Tyr Leu Lys 
                725                 730                 735     


Ser Lys Ser Ile Leu Glu Asp Val Ile Ala Gln Glu Gln Cys Asn Val 
            740                 745                 750         


Thr Tyr Leu Ile Ala Arg Tyr Met Gln Asp Val Leu Lys Asp Asp Ser 
        755                 760                 765             


Gln Gln Phe Tyr Ser Leu Pro Arg His Tyr Ser Cys Leu Ser Glu Lys 
    770                 775                 780                 


Asp Lys Tyr Leu Ser Leu Thr Glu Arg Glu Ala Ile Ala Lys Ser Asp 
785                 790                 795                 800 


Ala Leu Asn Ser Phe Lys Lys Arg Glu Arg Glu Lys Glu Asn Glu Asn 
                805                 810                 815     


Arg Arg Gly Asn Arg Arg Tyr Asn Lys Gly Glu Asn Lys Asn Thr Ile 
            820                 825                 830         


Lys Asp Arg Asp Thr Glu Glu Lys Phe Asn Ser Leu Tyr Arg Lys Met 
        835                 840                 845             


Asp Asn Asn Glu Arg Ile Leu Arg Arg Tyr Lys Val Gln Asp Met Leu 
    850                 855                 860                 


Leu Tyr Leu Leu Ala Cys Asp Ile Ile Lys Gly Ile Met Arg Glu Asp 
865                 870                 875                 880 


Phe Gly Tyr Lys Leu Ser Met Ile Thr Asp Gly Lys Asn Ser Asn Phe 
                885                 890                 895     


Phe Asp Tyr Lys Met Pro Glu Phe Lys Thr Thr Ile Thr Leu Lys Glu 
            900                 905                 910         


Gly Lys Lys Phe Thr Ile Lys Gln Gln Tyr Leu Lys Ile Lys Asn Tyr 
        915                 920                 925             


Gly Asp Phe Leu Lys Phe Ile Phe Asp Leu Arg Ile Asp Ser Leu Leu 
    930                 935                 940                 


Ser Asn Gly Thr Lys Val Glu Ile Asp Arg Asn Ile Leu Glu Asp Glu 
945                 950                 955                 960 


Leu Ser Asn Tyr Asp Gly Ser Arg Pro Lys Val Phe Glu Thr Leu Leu 
                965                 970                 975     


Met Ile Glu Lys Ile Val Val Glu Lys His Lys Glu Leu Lys Asp Leu 
            980                 985                 990         


Glu His Ile Thr Phe Gly Asp Val  Leu Asn Val Ile Lys  Met Glu Glu 
        995                 1000                 1005             


Gly Glu  Lys Lys Ile Leu Arg  Leu Ile Arg Asn Ala  Phe Ser His 
    1010                 1015                 1020             


Asn Tyr  Tyr Pro Thr Ile Lys  Asp Val Asn Tyr Asp  Asn Met Pro 
    1025                 1030                 1035             


Glu Val  Ala Glu Ser Leu Lys  Asp Ile Leu Glu Lys  Glu Ser Lys 
    1040                 1045                 1050             


Lys Leu  Thr Asn 
    1055         


<210>  1486
<211>  1110
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1486

Met Lys Ser Asn Glu Gln Thr Tyr Glu Asn Lys Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Val Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Ser Asn His Ile Ala Ser Asp Phe Gly Gln Ala Gln 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Thr Ser Phe Leu Cys Asn Lys Gly 
    50                  55                  60                  


Ile Lys Lys Leu Asn Trp Asn His Val Tyr Thr Lys Thr Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ala Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Arg Glu Asn Tyr Glu Lys Glu Gly Lys Asp Phe Ala Ala Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Thr Glu Leu Gln Ala Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Glu Asn Arg Lys Leu Thr Val 
    130                 135                 140                 


Ser Gly Glu Leu Ala Asp Phe Leu Thr Ile Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Thr Asp Ala Asp Tyr 
                165                 170                 175     


Glu Leu Val Glu Asn Arg Gln Ile Val Val Asp Asn Asn Thr Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ser Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asp Leu Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Lys 
            260                 265                 270         


Val Ser Thr Glu Glu Ala Lys Leu Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Leu Ala Asn Ser Thr Asn Ile Asp Glu Cys 
    290                 295                 300                 


Glu Lys Ile Leu Asp Glu Ile Asn Tyr Glu Asp Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg His Asn Asn Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Asp Glu Lys Asn Val Phe Glu Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Thr Tyr Thr Lys Gln Leu Ala Gly Glu 
        355                 360                 365             


Gln Thr Glu Arg Val Val Phe Glu Asn Val Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Asn Ser Phe Thr Asp Ser Glu Ser Val Gln Gln Arg Ile Asp Lys Gln 
385                 390                 395                 400 


Gln Arg Thr Gly Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Glu 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Ser Lys Glu Glu Val Ala Leu Leu Leu 
            420                 425                 430         


Pro Lys Ser Lys Pro Asp Thr Lys Val Ala Tyr Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Val Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Lys Ser Glu Gln Met Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Met Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Ser Lys Leu Pro Phe Gly Trp Asn Glu Phe Thr Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asn Ala Thr Met Lys Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Thr Ile Val Asn Asp Val Leu Ile Asp Tyr Asn Leu 
    530                 535                 540                 


Asn His Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Asp Val Glu Asp Ser Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Thr Arg Val Lys Val Leu Glu Lys His Lys Leu 
            580                 585                 590         


Asp Lys Ser Val Lys Thr Pro Lys Val Gly Glu Met Ala Ser Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Lys Glu Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Ile Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Ala Asp Ala Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Phe Glu Asn Gly Gly His Pro Phe Ile Gln Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Leu His Lys Thr Ser Gln Phe Tyr Glu Ala Tyr Leu Lys 
        675                 680                 685             


Glu Lys Gly Asn Lys Gln Val Ser Lys Phe Asn Pro Lys Thr Asn Lys 
    690                 695                 700                 


Thr Ser Lys Val Asp Asp Ser Trp Met Met Gln Gln Phe Tyr Thr Lys 
705                 710                 715                 720 


Glu Trp Asn Asp Glu Ile Lys Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Thr His Ile Pro Phe Thr Ile Arg Met Trp Glu Glu Lys 
            740                 745                 750         


Glu Lys Tyr Asn Leu Glu Thr Trp Leu His Asn Val Thr Val Gly Lys 
        755                 760                 765             


Asn Ile Lys Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe 
    770                 775                 780                 


Asp Glu Ala Leu Cys Ile Leu Leu Arg Lys Gln Leu Asp Thr Leu Ala 
785                 790                 795                 800 


Pro Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Leu Trp 
                805                 810                 815     


Trp Lys Thr Arg Asn Asp Asp Thr Gln Asp Phe Tyr Arg Ala Glu Arg 
            820                 825                 830         


Glu Tyr Ser Ile Tyr Asp Glu Lys Ile Val Phe Lys Ile Asn Ser Ser 
        835                 840                 845             


Gly His Phe Ala Asp Tyr Tyr Gln Lys Ala Leu Gly Lys Val Tyr Ser 
    850                 855                 860                 


Arg Leu Lys Ala Glu Arg Glu Thr Ala Arg Arg Thr Asn Asn Arg Leu 
865                 870                 875                 880 


Pro Pro Ile Glu His Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile 
                885                 890                 895     


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
            900                 905                 910         


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asn Ser Gln Asn Leu Lys 
        915                 920                 925             


Leu Asn Arg Ile Glu Ser Leu Leu Asn Asp Thr Thr Arg Ile Glu Gln 
    930                 935                 940                 


Lys Val Leu Ser Lys Thr Ile Val Ala Glu Arg Lys Gln Lys Asn Tyr 
945                 950                 955                 960 


Thr Glu Leu Arg Lys Tyr Ile His Asp Arg Arg Leu Pro Glu Leu Phe 
                965                 970                 975     


Glu Tyr Val Glu Ala Asp Glu Ile Gln Leu Glu Trp Leu Gln Asn Glu 
            980                 985                 990         


Leu Lys Glu Tyr Asn Thr Ala Lys  Gln Gln Val Phe Asp  Lys Val Phe 
        995                 1000                 1005             


Met Leu  Glu Lys Lys Ile Ile  Glu Thr Asp Arg Glu  Gly Val Ile 
    1010                 1015                 1020             


Glu Val  Met Ile Asn Thr Asp  Gly Val Leu Gln Lys  Gly Thr Ile 
    1025                 1030                 1035             


Gln His  Lys Pro Tyr Val Gln  Trp Met Lys Arg Lys  Gly Leu Ile 
    1040                 1045                 1050             


Ala Asp  His Glu Glu Gln Phe  Ile Asn Glu Val Arg  Asn Cys Phe 
    1055                 1060                 1065             


Ser His  Asn Gln Phe Pro His  Arg Lys Thr Met Glu  Leu Leu Ile 
    1070                 1075                 1080             


Pro Glu  Trp Ala Glu Gly Lys  Leu Ala Leu Gln Ile  Val Thr Val 
    1085                 1090                 1095             


Tyr Ser  Gln Leu Ile Ala Asp  Ile Val Asp Lys Ile  
    1100                 1105                 1110 


<210>  1487
<211>  1140
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1487

Met Glu Asn Asp Gln Gln Ile Leu Glu Asn Arg Arg Arg Thr Leu Ala 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Ser Asn His Leu Ala Ala Ser Phe Glu Gln Lys Val 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ala Ser Phe Leu Cys Asn Lys Ser 
    50                  55                  60                  


Ile Lys Lys Ile Asn Trp Asn His Val Tyr Ser Lys Ala Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ala Asp Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Arg Glu Thr Thr Asp Lys Glu Gly Lys Asp Phe Thr Ala Met Asn Glu 
            100                 105                 110         


Thr Leu Lys Leu Val Phe Asp Glu Leu Gln Ala Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Ala Asp Ser Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Val Glu Leu Ala Asp Phe Leu Thr Val Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Ala Asp Asp Asp Tyr 
                165                 170                 175     


Thr Met Val Glu Ser Lys Gln Ile Val Thr Pro Asp Asn Leu Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Val Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Leu Ala Tyr Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asp Leu Gly Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Glu 
            260                 265                 270         


Val Ile Thr Glu Glu Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Glu Glu Glu Arg 
    290                 295                 300                 


Glu Lys Ile Leu Asp Glu Ile Asp Tyr Glu Asp Tyr Ile Glu Ser Leu 
305                 310                 315                 320 


Thr Arg Arg Val Arg His Ser Asn Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Lys Tyr Asn Lys Gln Phe Asp Gly Glu 
        355                 360                 365             


Ala Thr Glu Cys Lys Val Val Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asn Gln Glu Thr Val Glu Leu Lys Ile Asp Ser Ala 
385                 390                 395                 400 


Gln Arg Thr Asn Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Glu Ala Arg Leu Leu 
            420                 425                 430         


Thr Lys Ala Lys Pro Glu Ser Lys Val Ser Tyr Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Lys Ala Glu Glu Met Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Lys Val Asn Asp Ser Gln Leu Met Ser Met Gln Phe Ile Asp Glu 
                485                 490                 495     


Ile Lys Glu Gln Leu Pro Ala Asp Trp Asn Glu Phe Gly Lys Arg Ser 
            500                 505                 510         


Asp Ser Lys Lys Lys Lys Ala Tyr Thr Asn Ala Ala Leu Gln Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Lys Val Leu Ala Asn Tyr Gln Leu 
    530                 535                 540                 


Asn Asp Lys Gln Val Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Ser Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Val Glu Lys His Lys Leu 
            580                 585                 590         


Asp Lys Ser Ala Arg Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Thr Asp Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Phe Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Tyr 
625                 630                 635                 640 


Ala Asp Thr Asp Lys Lys Ala Thr Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Lys Gly Gly His Pro Phe Leu Ala Asn Ile Asn 
            660                 665                 670         


Leu Arg Gln Ile Arg Lys Thr Ser Gln Leu Tyr Glu Leu Tyr Leu Val 
        675                 680                 685             


Glu Lys Ala Asn Lys Gln Val Lys Lys Met Asn Pro Lys Thr Gln Arg 
    690                 695                 700                 


Thr Ser Asn Val Asp Glu Ser Trp Met Met Lys Ser Phe Tyr Ala Lys 
705                 710                 715                 720 


Glu Trp Asn Glu Glu Met Gly Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Val Asn Lys Thr Asn Ile Pro Phe Thr Ile Arg Gln Trp Glu Glu Lys 
            740                 745                 750         


Glu Lys His Asn Leu Gln Ala Trp Leu His Asn Ile Thr Lys Gly Lys 
        755                 760                 765             


Thr Ser Lys Asp Gly Lys Lys Ala Ile Asp Leu Pro Thr Asn Leu Phe 
    770                 775                 780                 


Asp Asp Thr Leu Cys Glu Leu Leu Arg Glu Ala Leu Ile Asn Gln Gly 
785                 790                 795                 800 


Ile Asp Ala Thr Pro Thr Thr Lys Tyr Asn Glu Leu Leu Lys Gln Trp 
                805                 810                 815     


Trp Thr Ala Arg Glu Asp Ser Thr Gln Asp Phe Tyr Leu Ser Glu Arg 
            820                 825                 830         


Gln Tyr Asp Ile Tyr Asp Glu Lys Val Cys Phe Thr Ile Asn Ser Ser 
        835                 840                 845             


Ala His Phe Ala Asp Tyr Tyr Ala Pro Ala Leu Asn Lys Ala Tyr Ser 
    850                 855                 860                 


Arg Leu Arg Ala Glu Arg Asp Val Ala Arg Arg Thr Asp Lys Arg Leu 
865                 870                 875                 880 


Pro Pro Val Glu Arg Lys Asp Val Glu Arg Val Phe Lys Asn Thr Ile 
                885                 890                 895     


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
            900                 905                 910         


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asn Gln Gln Gln Leu Lys 
        915                 920                 925             


Leu Ser Lys Met Asp Ser Leu Leu Asn Glu Thr Lys Arg Ile Glu Gln 
    930                 935                 940                 


Thr Ile Asn Thr Gln Leu Ser Phe Asp His Lys Gly Lys Glu Ile Lys 
945                 950                 955                 960 


Asp Lys Thr Asn Ser Glu Ile Val Lys Thr Ile Val Ala Glu Arg Lys 
                965                 970                 975     


Gln Lys Asn Tyr Thr Glu Met Arg Lys Tyr Val His Asp Arg Arg Leu 
            980                 985                 990         


Pro Glu Leu Phe Glu Tyr Ile Asp  Gly Asn Glu Leu Pro  Leu Asp Val 
        995                 1000                 1005             


Leu Leu  Asn Glu Leu Arg Ala  Tyr Asn Thr Ala Lys  Gln Met Val 
    1010                 1015                 1020             


Phe Asp  Thr Val Phe Ala Leu  Glu Lys Lys Ile Ile  Glu Thr Asp 
    1025                 1030                 1035             


Pro Glu  Gly Leu Lys Gln Leu  Asn Val Gly Lys Asn  Gly Gln Ile 
    1040                 1045                 1050             


Gln Thr  Gly Asn Ile Gln His  Lys Pro Tyr Val Gln  Trp Leu Glu 
    1055                 1060                 1065             


Asn Lys  Gly Leu Ile Thr Asp  His Gln Lys Gln Phe  Ile Asn Met 
    1070                 1075                 1080             


Val Arg  Asn Ser Phe Ser His  Asn Gln Phe Pro Gln  Arg Ser Thr 
    1085                 1090                 1095             


Val Glu  Leu Leu Met Pro Glu  Trp Gln Asn Thr Asp  Ile Ala Leu 
    1100                 1105                 1110             


Gln Ile  Ala Arg Glu Tyr Gln  Gln Leu Ile Val Asp  Ile Ile Glu 
    1115                 1120                 1125             


Lys Ser  Leu His Pro His Lys  Gln His Gln Met Val  
    1130                 1135                 1140 


<210>  1488
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1488

Met Glu Thr Lys Gln Gln Val Gly Lys Gly Ile Ser Tyr Asp His Arg 
1               5                   10                  15      


Arg Pro Asp Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asp Gly Val Ile Gln Glu Phe Ala Met Arg Leu Asn Arg 
        35                  40                  45              


Glu Tyr Asp Pro Glu Asn Lys Asn Gln Ser Leu Phe Ser Tyr Phe Asn 
    50                  55                  60                  


Ile Asn Ala Ser Phe Thr Asp Trp Glu Arg Gly Val Asn Ile Leu Lys 
65                  70                  75                  80  


Glu Tyr Trp Pro Met Met Glu Phe Ile Asp Arg Pro Ala Thr Asp Lys 
                85                  90                  95      


Gln Phe Glu Ala Glu Lys Pro Glu Asn Arg Glu Ala Ala Lys Arg Lys 
            100                 105                 110         


Tyr Phe Leu Ala Thr Leu Gly Ala Leu Leu Thr Ser Ile Lys Asp Leu 
        115                 120                 125             


Arg His Tyr Tyr Thr His Tyr Tyr His Pro Pro Val His Leu Asn Asp 
    130                 135                 140                 


Asp Leu Phe Leu Phe Leu Asp His Ala Leu Leu Tyr Thr Ala Phe Asp 
145                 150                 155                 160 


Val Lys Lys Thr Lys Met Lys Asp Asp Lys Thr Arg Gln Leu Leu Asn 
                165                 170                 175     


Gln Asn Leu Ser Leu Glu Leu Glu Lys Leu Lys Lys Leu Lys Val Glu 
            180                 185                 190         


Glu Leu Lys Lys Lys Lys Glu Lys Gly Ile Lys Val Asn Leu Gln Asp 
        195                 200                 205             


Glu Lys Gly Ile Leu Asn Ala Ile Tyr Asn Asp Ala Phe Ala His Ile 
    210                 215                 220                 


Ile Thr Lys Glu Lys Asp Ser Asp Lys Asp Lys Leu Glu Thr Arg Tyr 
225                 230                 235                 240 


Lys Ser Ile Leu Pro Gln Asp Glu Ala Ala Glu Thr Gly Ile Asn Ile 
                245                 250                 255     


Ser Ile Ser Gly Leu Ile Phe Leu Leu Ser Leu Phe Leu Ser Arg Lys 
            260                 265                 270         


Glu Ile Glu Gln Leu Lys Ser Asn Ile Glu Gly Tyr Lys Gly Lys Val 
        275                 280                 285             


Leu Asn Ile Glu Thr Glu Val Asp Arg Lys His Asn Ser Leu Lys Tyr 
    290                 295                 300                 


Met Ala Thr His Trp Val Phe Ser Ile Leu Ala Phe Lys Gly Leu Lys 
305                 310                 315                 320 


Gln Arg Leu Thr Asn Ser Phe Glu Lys Glu Ser Leu Leu Ile Gln Met 
                325                 330                 335     


Met Asp Glu Leu Asn Lys Val Pro Asp Glu Leu Tyr Gln Thr Leu Ser 
            340                 345                 350         


Glu Thr Ala Lys Lys Glu Phe Leu Glu Asp Ile Asn Glu Tyr Val Ser 
        355                 360                 365             


Glu Gly Asp Asp Asn Glu Lys Ala Thr Tyr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Ser Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gln Phe Pro Thr Leu Lys Phe Gln Ile Phe Val Gly 
                405                 410                 415     


Gln Tyr Leu His Asp Asn Arg Pro Lys Thr Leu Ala Ser Asn Gly Met 
            420                 425                 430         


Thr Ala Gln Arg Met Ile Lys Glu Lys Ile Asn Leu Phe Gly Asn Leu 
        435                 440                 445             


Ser Glu Val Thr Lys His Lys Ser Asp Phe Phe Glu Lys Glu Ser Ala 
    450                 455                 460                 


Ala Gln Gly Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Trp Ala Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Val Tyr Ile Asp Met Ile Gly Lys Glu Gly Lys Ala 
                485                 490                 495     


Lys Glu Ile Gln Val Gln Ile Asn Lys Tyr Arg Lys Gln Leu Asn Pro 
            500                 505                 510         


Ala Pro Gln Arg Asp Lys Arg Ile Ser Lys Lys Glu Ile Ile Glu Gln 
        515                 520                 525             


Leu Tyr Lys Glu Lys Val Val Tyr Gly Asp Pro Thr Leu Met Leu Ser 
    530                 535                 540                 


Ala Asn Glu Leu Met Ala Leu Leu Tyr Glu Leu Ile Val Asn Gly Lys 
545                 550                 555                 560 


Ser Gly Ala Glu Leu Glu Asn Lys Ile Val Glu Gln Ile Ile Ala Arg 
                565                 570                 575     


Tyr Glu Gln Ile Glu Ala Tyr Asp Pro Thr Thr Gln Gln Leu Pro Thr 
            580                 585                 590         


Asn Gln Met Pro His Lys Leu Gln Lys Ser Arg Lys Asp Ser Lys Val 
        595                 600                 605             


Thr Asp Thr Asp Lys Leu Leu Lys Thr Ile Asp Lys Glu Ile Asp Glu 
    610                 615                 620                 


Gly Asn Lys Lys Leu Glu Leu Ile Ala Cys His Arg Lys Glu Trp Glu 
625                 630                 635                 640 


Glu Ala Glu Gln Arg Lys Lys Ser Gly Lys Arg Asn Asn Pro Gly Thr 
                645                 650                 655     


Lys Ser Arg Lys His Leu Phe Tyr Ala Ser Glu Met Gly Glu Glu Ala 
            660                 665                 670         


Thr Trp Ile Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Pro Ala Arg 
        675                 680                 685             


Ala Glu Trp Lys Gly Thr His His Ser Glu Leu Gln Arg Leu Leu Ala 
    690                 695                 700                 


Phe Tyr Ser Thr Gln Arg Leu Glu Ala Trp Gln Leu Val Glu Ser Val 
705                 710                 715                 720 


Trp Thr Ala Asn Thr His Ser Phe Trp Glu Glu Asn Phe Lys Glu Ala 
                725                 730                 735     


Phe Tyr Lys Pro Glu Phe Glu Asn Phe Tyr Gly Ala Tyr Ile Glu Ile 
            740                 745                 750         


Arg Thr Lys Ile Leu Thr Thr Cys Arg Ser Ile Leu Glu Asn Asn Pro 
        755                 760                 765             


Glu Ala Thr Met Asn Asn Asp Thr Glu Lys Glu Trp Asp Lys Val Phe 
    770                 775                 780                 


Thr Leu Phe Asp Lys Arg Leu Tyr Arg Thr Ser Thr Thr Asp Glu Gln 
785                 790                 795                 800 


Lys Lys Gln Leu Leu Thr Lys Pro Phe Ala Phe Pro Arg Gly Leu Phe 
                805                 810                 815     


Asp Asp Lys Pro Thr Phe Leu Pro Gly Ser Lys Pro Asn Glu Asn Pro 
            820                 825                 830         


Glu Arg Phe Ala Ala Trp Tyr Ser Tyr Gly Tyr Thr Tyr Ser Gly Lys 
        835                 840                 845             


Phe Gln Ser Phe Tyr Asp Met Pro Arg Asn Tyr Ser Asp Trp Tyr Lys 
    850                 855                 860                 


Lys Leu Lys Glu Asp Gly Lys Leu Pro Arg Leu Asp Lys Lys Thr Glu 
865                 870                 875                 880 


Gln Glu Lys Ile Leu Arg Phe Arg Met Asp Cys Asp Leu Asn Ile Lys 
                885                 890                 895     


His Ile Arg Phe Gln Asp Ile Tyr Val Lys Leu Met Val Asp Ser Leu 
            900                 905                 910         


Tyr Lys Ala Val Phe Gly Gln Gln Pro Glu Phe Asp Leu Ser His Leu 
        915                 920                 925             


Tyr Asp Thr Arg Ser Glu Arg Tyr Glu Asn Asn Thr Ile Ala Gln Arg 
    930                 935                 940                 


Gln Lys Ser Arg Gln Glu Gly Asp Asn Ser Asp Asn Ala Ile Asn Glu 
945                 950                 955                 960 


Asn Tyr Val Trp Asn Lys Thr Phe Ala Ile Ser Leu Tyr Asn Gly Arg 
                965                 970                 975     


Ile Thr Glu Ser Gln Val Lys Leu Lys Asp Val Gly Lys Phe Arg Arg 
            980                 985                 990         


Phe Ala Thr Asp Pro Arg Val Gln  Thr Leu Ile Ser Tyr  Asp Asp Thr 
        995                 1000                 1005             


Arg Thr  Trp Thr Lys Leu Glu  Ile Glu Asn Glu Leu  Asp Asn Lys 
    1010                 1015                 1020             


Ala Asp  Ala Tyr Glu Pro Ile  Arg Arg Thr Gln Ser  Leu Lys Ala 
    1025                 1030                 1035             


Ile Gln  Gln Leu Glu Lys Asn  Ile Leu Lys Lys Asn  Gly Phe Asn 
    1040                 1045                 1050             


Gly Lys  Gln His Pro Glu Glu  Leu Lys His Asn Gly  Asn Pro Asn 
    1055                 1060                 1065             


Phe Arg  Lys Tyr Ile Ala Asn  Gly Leu Leu Lys His  Arg Thr Asp 
    1070                 1075                 1080             


Ile Arg  Gln Glu Glu Leu Ala  Leu Ile Ser Asp Thr  Glu Phe Gln 
    1085                 1090                 1095             


Glu Ile  Gly Leu Glu Arg Ile  Arg Gln Thr Asn Pro  Leu Ile Gln 
    1100                 1105                 1110             


Lys Ala  Tyr Leu Leu Ile Leu  Leu Arg Asn Lys Phe  Gly His Asn 
    1115                 1120                 1125             


Gln Leu  Pro Asp Gln Glu His  Phe Arg Leu Met Arg  Ser Ile Tyr 
    1130                 1135                 1140             


Pro Tyr  Asn Gln Gln Glu Ser  Tyr Ser Ala Tyr Phe  Asn His Val 
    1145                 1150                 1155             


Ile Thr  Gln Ile Ile Glu Glu  Leu Asn Thr 
    1160                 1165             


<210>  1489
<211>  1047
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1489

Met Glu Glu Gln Phe Leu Gln Lys Glu Arg Asn Met Gly Asp Asn Pro 
1               5                   10                  15      


Tyr Tyr Phe Cys His Phe Ile Asn Met Ala His His Asn Val Asn Leu 
            20                  25                  30          


Ile Leu Glu Glu Ile Tyr Asn Ser Val Tyr Glu Lys Tyr Thr Gln Asp 
        35                  40                  45              


Lys Glu Glu Asn Ile Lys Ala Ile Cys Asn Ser Met Ile Ser Lys Ser 
    50                  55                  60                  


Arg Lys Asn Pro Asp Glu Lys Ala Lys Met Met Asn Met Cys Ile Arg 
65                  70                  75                  80  


His Phe Pro Phe Leu Asp Tyr Tyr Lys Glu Lys Asp Gln Asn Ser Asp 
                85                  90                  95      


Val Leu Thr Ile Leu Leu Asn Gln Phe Leu Val Pro Leu His Gly Leu 
            100                 105                 110         


Arg Asn Gln Phe Ser His Tyr Lys His Pro Gln Glu Ala Tyr Cys Ile 
        115                 120                 125             


Ser Gly Phe Asp Leu Leu Phe Glu Gln Ala Lys Thr Gly Ala Gln Met 
    130                 135                 140                 


Arg Met Lys Tyr Ser Asp Glu Asp Ile Ser Lys Val Lys Ser Lys Val 
145                 150                 155                 160 


Val Asn His Asp Ser Ile Leu Thr Glu Arg Gly Ile Leu Phe Phe Ile 
                165                 170                 175     


Cys Leu Phe Leu Asp Lys Arg Asn Ile Tyr Leu Phe Leu Ser Lys Ile 
            180                 185                 190         


Lys Gly Phe Arg Asp Arg Arg Pro Asp Glu Lys Tyr Lys Ser Ala Thr 
        195                 200                 205             


Leu Glu Val Phe Ser Gln Tyr Tyr Cys His Val Pro Tyr Arg Lys Leu 
    210                 215                 220                 


Asp Ser Ser Asp Val Ala Leu Asp Met Leu Asn Glu Leu Asn Arg Cys 
225                 230                 235                 240 


Pro Lys Ala Leu Tyr Asp Val Leu Ser Asp Glu Asp Arg Glu Arg Phe 
                245                 250                 255     


Ile Val Asp Asn Val Glu Asn Ala Asp Asn Arg Asp Glu Ile Ser Asp 
            260                 265                 270         


Glu Asp Asp Glu Glu Met Pro Arg Ser Val Met Lys Arg Ser Asp Asp 
        275                 280                 285             


Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Glu Lys Gln Asn Asn Leu 
    290                 295                 300                 


Asp Glu Ile Ser Phe His Leu Tyr Leu Gly Arg Lys Glu Ala Lys Pro 
305                 310                 315                 320 


Ala His Glu Lys Val Ile Asn Gly Glu Met Arg Thr His Lys Ile Leu 
                325                 330                 335     


Lys Asp Ile His Val Phe Gly Arg Leu Glu Asn Tyr Arg Asn Glu Glu 
            340                 345                 350         


Ile Cys Asn Ala Ile Lys Asn Arg Glu Asp Ile Glu Phe Tyr Ala Pro 
        355                 360                 365             


Ser Tyr Arg Ile Val Glu Asn Arg Ile Gly Leu Leu Leu Arg Arg Gln 
    370                 375                 380                 


Asn Asp Phe Thr Leu Glu Glu Ala Asn Glu Glu Lys Ile Phe Glu Gly 
385                 390                 395                 400 


Asn Leu Cys Pro Asp Val Ile Leu Ser Thr His Glu Leu Gly Ala Leu 
                405                 410                 415     


Phe Phe Tyr Asn Tyr Leu His Lys Lys Gly Trp Ile Glu Ser Ala Pro 
            420                 425                 430         


Tyr Leu Tyr Ile Arg Asn Phe Ile Ser Asp Phe Lys Arg Phe Ile Glu 
        435                 440                 445             


Asp Ile Lys Asn Gly Lys Leu Thr Pro Val Glu Ser Glu Asp Asp Phe 
    450                 455                 460                 


Tyr Leu Ile Lys Lys Lys Lys Arg Asp Glu Thr Lys Asp Asn Asp Lys 
465                 470                 475                 480 


Lys Ser Ile Ala Val Gln Glu Arg Arg Arg Glu Lys Leu Lys Glu Lys 
                485                 490                 495     


Leu Lys Gly Tyr His Leu Glu Pro Asp Trp Ile Pro Asp Ala Cys Arg 
            500                 505                 510         


Glu Tyr Met Leu Gly Tyr Lys Ala Asp Gln Lys Asp Tyr Tyr Thr Lys 
        515                 520                 525             


Gln Arg Phe Cys Ser Met Lys Lys Glu Thr Asp Ser Arg Ile Lys Gln 
    530                 535                 540                 


Ile Glu Ala Ile Arg Lys Arg Glu Asp Asn Ser Ile Ile Arg Gln Thr 
545                 550                 555                 560 


Arg Val Gly Glu Ile Ala Gln Glu Leu Ala Arg Asp Ile Val Phe Leu 
                565                 570                 575     


Ile Pro Pro Tyr Lys Asn Glu Lys Gly Ala Asp Thr Lys Ile Asn Asn 
            580                 585                 590         


Met Glu Phe Asp Val Leu Gln Lys Met Leu Ala Tyr Phe Pro Leu Asn 
        595                 600                 605             


Lys Lys Asp Ile Tyr Pro Phe Leu Lys Asn Ile Arg Asn Trp Asp Lys 
    610                 615                 620                 


His Pro Phe Leu Lys Tyr Thr Leu His Thr Glu His Gln Ser Leu Leu 
625                 630                 635                 640 


Asp Phe Tyr Gln Asp Tyr Leu Asn Cys Lys Lys Arg Trp Ile Ser Lys 
                645                 650                 655     


Asn Ile Arg Tyr Asp Lys Gln Lys Gly Asn Tyr Leu Val Asp Ala Asn 
            660                 665                 670         


Lys Thr Glu Gln Glu Cys Arg Tyr Phe Leu Lys Thr Asp Lys Leu Arg 
        675                 680                 685             


Thr Ala Lys Glu Lys Glu Tyr Phe Glu Glu Pro Asp Lys Pro Val Tyr 
    690                 695                 700                 


Leu Pro Thr Gly Phe Phe Val Asp Pro Ile Val Glu Ala Met Arg Lys 
705                 710                 715                 720 


Asn Gly Tyr Glu Leu Lys Glu Asn Ser Asn Ile Val Gly Cys Leu Lys 
                725                 730                 735     


Ile Tyr Phe Val Ser Lys Ile Gln Pro Met Tyr Asp Leu Ser Arg Tyr 
            740                 745                 750         


Tyr Thr Tyr Tyr Asp Gly Lys Glu Glu Arg Ser Met Gln Leu Asp Asp 
        755                 760                 765             


Leu Lys Val Phe Ile Lys Glu Lys Phe Gly Asn Lys Arg Thr Asp Asp 
    770                 775                 780                 


Asn Thr Ile Arg Phe Leu Lys Lys Ala Ala Lys Arg Ile Arg Glu Asn 
785                 790                 795                 800 


Glu Ser Glu Ile Leu Val Arg Gln Met Asp Asp Cys Ala Leu Phe Leu 
                805                 810                 815     


Met Val Asn Asp Leu Leu Glu Gly Gly Lys Phe Asn Asp Glu Asp Ile 
            820                 825                 830         


Glu Asn Ile Gly Tyr Asn Lys His His Asn Leu Leu Asp His Glu Tyr 
        835                 840                 845             


Asp Met Cys Glu Thr Ile Tyr Gly Arg Lys Val Thr Ala Arg Leu Pro 
    850                 855                 860                 


Ile Lys Arg Tyr Gly Glu Phe Arg Arg Phe Met Lys Asp Arg Arg Leu 
865                 870                 875                 880 


Gln Asn Leu Val Lys Tyr Tyr Pro Gly Asp His Glu Thr Pro Ile Pro 
                885                 890                 895     


Ser Gly Ile Pro Glu Ser Gly Lys Ala Met Glu Lys Asn Lys Lys Tyr 
            900                 905                 910         


Thr Tyr Ser Asn Leu Cys Asp Glu Leu Glu Ile Tyr Asp Lys Glu Arg 
        915                 920                 925             


Asp Asn Val Leu Asn Leu Ile Tyr Glu Val Asp Lys Ile Leu Val Asp 
    930                 935                 940                 


His Phe Pro Asp Lys Ile Met Lys Glu Glu Asp Gly Tyr Tyr Glu His 
945                 950                 955                 960 


Tyr His Cys Leu Asp Phe Ala Lys Lys Glu Phe Gly Leu Glu Ser Asp 
                965                 970                 975     


Val Glu Leu Leu Ser Gln Asp Asn Phe Lys Asp Leu Arg Asn Ala Leu 
            980                 985                 990         


Tyr His Asn Gln Ile Pro Tyr Asn  Asp Trp Val Ala Asp  Lys Ile Ser 
        995                 1000                 1005             


Lys Asp  Thr Glu Glu Pro Met  Tyr Val Arg Arg Ile  Phe Ser Phe 
    1010                 1015                 1020             


Ile Arg  Thr Val Tyr Ser Arg  Leu Leu Asp Gln Ile  Lys Ile Lys 
    1025                 1030                 1035             


Ile Glu  Lys Asp Glu Tyr Lys  Cys Lys 
    1040                 1045         


<210>  1490
<211>  1140
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1490

Met Glu Asn Asp Gln Gln Ile Leu Glu Asn Arg Arg Arg Thr Leu Ala 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Ser Asn His Leu Ala Thr Ser Phe Glu Gln Lys Ala 
        35                  40                  45              


Leu His Glu Glu Gly Gln Ile Pro Ala Ser Phe Leu Cys Asn Lys Ser 
    50                  55                  60                  


Ile Lys Lys Ile Asn Trp Asn His Val Tyr Ser Lys Ala Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Ile Phe Asp Ala Asp Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Arg Glu Thr Ser Asp Lys Glu Gly Lys Asp Phe Thr Ala Met Asn Glu 
            100                 105                 110         


Thr Leu Lys Leu Val Phe Asp Glu Leu Gln Ala Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Ala Asp Ser Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Val Glu Leu Ala Asp Phe Leu Thr Val Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Ala Asp Asp Asp Tyr 
                165                 170                 175     


Ala Val Val Glu Ser Lys Gln Ile Val Thr Pro Asp Asn Gln Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Ile Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Val Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Leu Ala Tyr Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asp Leu Arg Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Glu 
            260                 265                 270         


Val Ile Thr Glu Glu Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Glu Glu Glu Arg 
    290                 295                 300                 


Glu Lys Ile Leu Asp Glu Ile Asp Tyr Glu Asp Tyr Ile Glu Ser Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg His Ser Asn Arg Phe Pro Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Glu Lys Tyr Asn Lys Gln Phe Asp Gly Glu 
        355                 360                 365             


Ala Thr Glu Arg Lys Val Val Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asn Gln Glu Thr Val Glu Leu Lys Ile Asp Ser Ala 
385                 390                 395                 400 


Gln Arg Thr Asn Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Glu Ala Arg Leu Leu 
            420                 425                 430         


Thr Lys Ala Lys Pro Glu Ser Lys Val Ser Tyr Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Lys Ala Glu Glu Met Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Lys Val Asn Asp Ser Gln Leu Met Asn Met Gln Phe Ile Asp Glu 
                485                 490                 495     


Ile Lys Glu Gln Leu Pro Ala Asp Trp Asn Glu Phe Gly Lys Arg Ser 
            500                 505                 510         


Asp Ser Lys Lys Lys Lys Ala Tyr Thr Asn Ala Ala Arg Gln Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Lys Val Leu Ala Asn Tyr Gln Leu 
    530                 535                 540                 


Asn Asp Lys Gln Val Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Val 
545                 550                 555                 560 


Lys Glu Val Asp Asp Ser Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Met Glu Lys His Lys Val 
            580                 585                 590         


Asp Lys Ser Ala Arg Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Thr Asp Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Tyr 
625                 630                 635                 640 


Ala Asp Asn Glu Lys Lys Ala Thr Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Lys Asp Gly His Pro Phe Leu Ala Asn Ile Asn 
            660                 665                 670         


Leu Arg Gln Ile Arg Lys Thr Ser Gln Leu Tyr Glu Leu Tyr Leu Val 
        675                 680                 685             


Glu Lys Ala Asn Lys Gln Val Lys Lys Met Asn Pro Lys Thr Gln Arg 
    690                 695                 700                 


Thr Asn Asn Val Asp Glu Ser Trp Met Met Lys Ser Phe Tyr Ala Lys 
705                 710                 715                 720 


Glu Trp Asn Glu Glu Met Gly Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Thr Asn Ile Pro Phe Thr Ile Arg Gln Trp Glu Glu Lys 
            740                 745                 750         


Glu Lys His Asn Leu Gln Ala Trp Leu His Asn Ile Thr Lys Gly Lys 
        755                 760                 765             


Thr Ser Lys Asp Gly Lys Lys Ala Val Asp Leu Pro Thr Asn Leu Phe 
    770                 775                 780                 


Asp Asp Thr Leu Cys Glu Leu Leu Arg Glu Ala Leu Ile Asn Glu Gly 
785                 790                 795                 800 


Ile Asp Ala Thr Pro Thr Thr Lys Tyr Asn Glu Leu Leu Lys His Trp 
                805                 810                 815     


Trp Thr Ala Arg Glu Asp Ser Thr Gln Asp Phe Tyr Leu Ser Glu Arg 
            820                 825                 830         


Gln Tyr Asp Ile Tyr Asp Glu Lys Val Cys Phe Thr Ile Asn Ser Ser 
        835                 840                 845             


Ala His Phe Ala Asp Tyr Tyr Ala Pro Ala Leu Ser Lys Ala Tyr Ser 
    850                 855                 860                 


Arg Leu Arg Ala Glu Arg Asp Val Ala Arg Arg Thr Asp Lys Arg Leu 
865                 870                 875                 880 


Pro Pro Val Glu Arg Lys Asp Val Glu Arg Val Phe Lys Asn Thr Ile 
                885                 890                 895     


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
            900                 905                 910         


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asn Gln Gln Gln Leu Lys 
        915                 920                 925             


Leu Ser Lys Met Asp Ser Leu Leu Asn Glu Thr Lys Arg Ile Glu Gln 
    930                 935                 940                 


Val Ile Asn Thr Gln Leu Ser Phe Asp Gln Lys Gly Lys Glu Ile Lys 
945                 950                 955                 960 


Asp Lys Thr Asn Leu Glu Ile Val Lys Thr Ile Val Ala Glu Arg Lys 
                965                 970                 975     


Gln Lys Asn Tyr Thr Glu Met Arg Lys Tyr Val His Asp Arg Arg Leu 
            980                 985                 990         


Pro Glu Leu Phe Glu Tyr Ile Asp  Gly Asn Glu Leu Pro  Leu Asp Met 
        995                 1000                 1005             


Leu Leu  Asn Glu Leu Arg Ala  Tyr Asn Thr Ala Lys  Gln Val Val 
    1010                 1015                 1020             


Phe Asp  Thr Val Phe Ala Leu  Glu Lys Lys Ile Ile  Glu Thr Asp 
    1025                 1030                 1035             


Pro Glu  Gly Leu Lys Gln Leu  Asn Val Ser Lys Asp  Gly Gln Ile 
    1040                 1045                 1050             


Gln Thr  Gly Asn Ile Gln His  Lys Pro Tyr Val Gln  Trp Leu Glu 
    1055                 1060                 1065             


Asn Lys  Gly Leu Ile Thr Asp  Lys Asp Lys Gln Phe  Ile Asn Met 
    1070                 1075                 1080             


Val Arg  Asn Ser Phe Ser His  Asn Gln Phe Pro Gln  Arg Ser Thr 
    1085                 1090                 1095             


Val Glu  Leu Leu Met Pro Val  Trp Gln Asn Thr Asn  Ile Ala Leu 
    1100                 1105                 1110             


Gln Ile  Ala Arg Glu Tyr Gln  Gln Leu Ile Val Asp  Ile Ile Glu 
    1115                 1120                 1125             


Lys Ser  Leu His Pro His Lys  Gln His Gln Met Val  
    1130                 1135                 1140 


<210>  1491
<211>  1110
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1491

Met Lys Ser Asn Glu Gln Thr Tyr Glu Asn Lys Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Val Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Ser Asn His Ile Ala Ser Asp Phe Gly Gln Ala Gln 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Thr Ser Phe Leu Cys Asn Lys Gly 
    50                  55                  60                  


Ile Lys Lys Leu Asn Trp Asn His Val Tyr Thr Lys Thr Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ala Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Arg Glu Asn Tyr Glu Lys Glu Gly Lys Asp Phe Ala Ala Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Thr Glu Leu Gln Ala Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Glu Asn Arg Lys Leu Thr Val 
    130                 135                 140                 


Ser Gly Glu Leu Ala Asp Phe Leu Thr Ile Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Thr Asp Ala Asp Tyr 
                165                 170                 175     


Glu Leu Val Glu Asn Arg Gln Ile Val Val Asp Asn Asn Thr Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ser Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asp Leu Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Lys 
            260                 265                 270         


Val Ser Thr Glu Glu Ala Lys Leu Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Leu Ala Asn Ser Thr Asn Ile Asp Glu Cys 
    290                 295                 300                 


Glu Lys Ile Leu Asp Glu Ile Asn Tyr Glu Asp Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg His Asn Asn Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Asp Glu Lys Asn Val Phe Glu Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Thr Tyr Thr Lys Gln Leu Ala Gly Glu 
        355                 360                 365             


Gln Thr Glu Arg Val Val Phe Glu Asn Val Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Asn Ser Phe Thr Asp Ser Glu Ser Val Gln Gln Arg Ile Asp Lys Gln 
385                 390                 395                 400 


Gln Arg Thr Gly Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Glu 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Ser Lys Glu Glu Val Ala Leu Leu Leu 
            420                 425                 430         


Pro Lys Ser Lys Pro Asp Thr Lys Val Ala Tyr Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Val Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Lys Ser Glu Gln Met Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Met Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Ser Lys Leu Pro Phe Gly Trp Asn Glu Phe Thr Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asn Ala Thr Met Lys Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Thr Ile Val Asn Asp Val Leu Ile Asp Tyr Asn Leu 
    530                 535                 540                 


Asn His Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Asp Val Glu Asp Ser Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Thr Arg Val Lys Val Leu Glu Lys His Lys Leu 
            580                 585                 590         


Asp Lys Ser Val Lys Thr Pro Lys Val Gly Glu Met Ala Ser Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Lys Glu Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Ile Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Ala Asp Ala Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Phe Glu Asn Gly Gly His Pro Phe Ile Gln Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Leu His Lys Thr Ser Gln Phe Tyr Glu Ala Tyr Leu Lys 
        675                 680                 685             


Glu Lys Gly Asn Lys Gln Val Ser Lys Phe Asn Pro Lys Thr Asn Lys 
    690                 695                 700                 


Thr Ser Lys Val Asp Asp Ser Trp Met Met Gln Gln Phe Tyr Thr Lys 
705                 710                 715                 720 


Glu Trp Asn Asp Glu Ile Lys Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Thr His Ile Pro Phe Thr Ile Arg Met Trp Glu Glu Lys 
            740                 745                 750         


Glu Lys Tyr Asn Leu Glu Thr Trp Leu His Asn Val Thr Val Gly Lys 
        755                 760                 765             


Asn Ile Lys Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe 
    770                 775                 780                 


Asp Glu Ala Leu Cys Ile Leu Leu Arg Lys Gln Leu Asp Thr Leu Ala 
785                 790                 795                 800 


Pro Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Leu Trp 
                805                 810                 815     


Trp Lys Thr Arg Asn Asp Asp Thr Gln Asp Phe Tyr Arg Ala Glu Arg 
            820                 825                 830         


Glu Tyr Ser Ile Tyr Asp Glu Lys Ile Val Phe Lys Ile Asn Ser Ser 
        835                 840                 845             


Gly His Phe Ala Asp Tyr Tyr Gln Lys Ala Leu Gly Lys Val Tyr Ser 
    850                 855                 860                 


Arg Leu Lys Ala Glu Arg Glu Thr Ala Arg Arg Thr Asn Asn Arg Leu 
865                 870                 875                 880 


Pro Pro Ile Glu His Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile 
                885                 890                 895     


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
            900                 905                 910         


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asn Ser Gln Asn Leu Lys 
        915                 920                 925             


Leu Asn Arg Ile Glu Ser Leu Leu Asn Asp Thr Thr Arg Ile Glu Gln 
    930                 935                 940                 


Lys Val Leu Ser Lys Thr Ile Val Ala Glu Arg Lys Gln Lys Asn Tyr 
945                 950                 955                 960 


Thr Glu Leu Arg Lys Tyr Ile His Asp Arg Arg Leu Pro Glu Leu Phe 
                965                 970                 975     


Glu Tyr Val Glu Ala Asp Glu Ile Gln Leu Glu Trp Leu Gln Asn Glu 
            980                 985                 990         


Leu Lys Glu Tyr Asn Thr Ala Lys  Gln Gln Val Phe Asp  Lys Val Phe 
        995                 1000                 1005             


Met Leu  Glu Lys Lys Ile Ile  Glu Thr Asp Arg Glu  Gly Val Ile 
    1010                 1015                 1020             


Glu Val  Met Ile Asn Thr Asp  Gly Val Leu Gln Lys  Gly Thr Ile 
    1025                 1030                 1035             


Gln His  Lys Pro Tyr Val Gln  Trp Met Lys Arg Lys  Gly Leu Ile 
    1040                 1045                 1050             


Ala Asp  His Glu Glu Gln Phe  Ile Asn Glu Val Arg  Asn Cys Phe 
    1055                 1060                 1065             


Ser His  Asn Gln Phe Pro His  Arg Lys Thr Met Glu  Leu Leu Ile 
    1070                 1075                 1080             


Pro Glu  Trp Ala Glu Gly Lys  Leu Ala Leu Gln Ile  Val Thr Val 
    1085                 1090                 1095             


Tyr Ser  Gln Leu Ile Ala Asp  Ile Val Asp Lys Ile  
    1100                 1105                 1110 


<210>  1492
<211>  1171
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1492

Met Glu Thr Asn Asn Thr Thr Ile Thr Arg Arg Tyr Gly Leu Lys Glu 
1               5                   10                  15      


Thr Pro Trp Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg His Asn Met 
            20                  25                  30          


Phe Leu Leu Val Asn His Val Thr Glu Lys Phe Ala Tyr Leu Asn Glu 
        35                  40                  45              


Lys Pro Leu Thr Ser Asp Glu Asp Ile Val Lys Asp Asp His Leu Leu 
    50                  55                  60                  


Ala Lys Ile Phe Asp Pro Asp Lys Ser Val Tyr Glu Thr Glu Arg Met 
65                  70                  75                  80  


Lys Val Tyr Lys Tyr Leu Thr Ser Arg His Tyr Leu Pro Cys Ile Arg 
                85                  90                  95      


Val Phe His Glu Gly Gln Gly Asp Val Thr Asp Thr Asn Pro Ile Val 
            100                 105                 110         


Asp Tyr Glu Gly Leu His Ala Phe Leu Arg Ser Ala Phe Asn Leu Leu 
        115                 120                 125             


Asn Ala Trp Arg Asn Ala Phe Thr His Tyr Leu Ala Ile Asp Asp Asn 
    130                 135                 140                 


Gly Asn Arg Leu Gln Glu Arg Ser Leu Val Ile Glu Gln Asp Met Lys 
145                 150                 155                 160 


Gly Cys Leu Glu Arg Leu Phe Ala Arg Ala Pro Asp Phe Ser Phe Lys 
                165                 170                 175     


Arg Phe Glu Ala Thr His Glu Glu Lys Asp Phe Asp His Leu Ser Phe 
            180                 185                 190         


Tyr Arg Leu Phe Ser Glu Asp Asn Asp Leu Gln Leu Ser Glu Gln Gly 
        195                 200                 205             


Phe Tyr Phe Phe Ile Asn Leu Phe Leu Glu Arg Gly Tyr Ala Met Lys 
    210                 215                 220                 


Phe Leu Lys Lys Phe Arg Gly Phe Lys Asn Glu Thr Thr Pro Ser Phe 
225                 230                 235                 240 


Arg Ala Thr Leu Gln Ala Phe Thr Ala Tyr Thr Pro Arg Val Pro Asp 
                245                 250                 255     


Val Arg Leu Asp Thr Glu Asp Ser Arg Gln Thr Leu Leu Leu Glu Met 
            260                 265                 270         


Leu Asn Glu Leu Asn Arg Cys Pro Gly Glu Ile Tyr Lys Arg Leu Lys 
        275                 280                 285             


Glu Glu Asp Lys Gln Lys Leu Val Pro His Lys Gly Arg Ala Glu Glu 
    290                 295                 300                 


Ala Ser His Val Leu Ala Thr Thr Asp Tyr Arg Asp Ile Ser Asp Glu 
305                 310                 315                 320 


Asp Ile Asp Gly Leu Leu Ser Asp Ile Ser Pro Leu Tyr Arg Gly Gly 
                325                 330                 335     


Asp Arg Phe Pro Tyr Phe Ala Ala Arg Tyr Ile Asp Glu Phe Asp Leu 
            340                 345                 350         


Leu Pro Asn Ile Arg Phe Gln Ile Thr Leu Gly Lys Leu Gln Val Asp 
        355                 360                 365             


Ala Tyr Glu Lys Asn Ile Ala Gly Glu Ile Ile Glu Arg Arg Val Val 
    370                 375                 380                 


Arg Thr Val His Ala Tyr Gly Lys Leu Ser Asp Phe Thr Asn Arg Gln 
385                 390                 395                 400 


Asn Glu Val Leu Glu Ile Leu Gln Gln Gln Ser Val Ala Gly Glu Gly 
                405                 410                 415     


Ser Tyr Phe Gln Gln Tyr Ala Pro His Tyr Asn Met Glu Asn Asn Gln 
            420                 425                 430         


Leu Ser Phe Tyr Leu Phe Asn Glu Glu Asp Gln Asp Lys Val Lys Tyr 
        435                 440                 445             


Pro Ser Gln Leu Pro Gly Asn Thr Ser Gly Asn Ala Pro Thr Gly Phe 
    450                 455                 460                 


Leu Ser Leu Asn Asp Leu Pro Lys Leu Ala Leu Leu Gly Met Asp Lys 
465                 470                 475                 480 


Asn Lys Leu Ile Ala Glu Gln Val Ile Arg Asp Phe Ile Asn Ile Asn 
                485                 490                 495     


Arg Gly Leu Ile Leu Asn Phe Glu Ala Leu Glu Lys Leu Arg Ala Arg 
            500                 505                 510         


Leu Ser Leu Val Pro Lys Glu Phe Thr Arg Arg Val Val Asn Glu Lys 
        515                 520                 525             


Ser Ile Lys Gly Arg Asp Gly Met Pro Asp Tyr Leu Asn Lys Lys Lys 
    530                 535                 540                 


Glu Ala Arg Leu Leu Gln Ser Leu Arg Leu Ser Arg Glu Glu Leu Cys 
545                 550                 555                 560 


Arg Leu Glu Ser Asp Glu Leu Lys Arg Arg Ile Arg Asn Ser Lys Gln 
                565                 570                 575     


Leu Glu Tyr Ala Asn Gln Ile Arg Tyr Val His Phe Leu Glu Asn Arg 
            580                 585                 590         


Lys Lys Glu Leu Gln Glu His Leu Pro Glu Gly Leu Arg Val Asp Gln 
        595                 600                 605             


Leu Pro Glu Gln Val Val Arg His Leu Leu Asn Ile Asn Asp His Ser 
    610                 615                 620                 


Ser Glu Lys Ile Ile His His Lys Ile Lys Ala Ile Tyr Asp Asp Cys 
625                 630                 635                 640 


Arg Ile Arg Leu Arg Arg Ile Glu Thr Gln Glu Leu Lys Pro Glu Glu 
                645                 650                 655     


Glu Arg Asn Leu Lys Leu Gly Glu Leu Ala Thr Phe Leu Ser Arg Asp 
            660                 665                 670         


Ile Ile Asp Met Val Val Asp Gln Glu Val Lys Gln Lys Ile Thr Ser 
        675                 680                 685             


Pro Tyr Tyr Asn Lys Leu Gln Thr Lys Ile Ser Tyr Phe Ser Val Ser 
    690                 695                 700                 


Arg Glu Glu Ile Ile Ala Leu Cys Asn Glu Leu Gln Leu Phe Gln Arg 
705                 710                 715                 720 


Glu Ser Gly His Val Phe Leu Ser Arg Glu Met Ile Met Gln Ser Arg 
                725                 730                 735     


Gly Ile Val Asp Phe Tyr Lys His Tyr Leu Thr Asp Lys Leu Glu Trp 
            740                 745                 750         


Ile Lys Asn Thr Leu Leu Ser Asp Asn Pro Arg Gly Gly Arg Tyr Thr 
        755                 760                 765             


Leu Pro Glu Lys Ala Ile Leu Pro Leu Ser Phe Phe Lys Ile Arg Glu 
    770                 775                 780                 


Lys Ala Gly Ser Gly Asp Phe Arg Gln Trp Leu Glu Arg Lys Lys Gln 
785                 790                 795                 800 


Met Pro Val Ser Leu Pro His Ser Leu Phe Asp Lys Glu Leu Glu Asp 
                805                 810                 815     


Arg Leu Ser Trp Arg Leu His Lys Glu Asn Ile Ser Phe Asn Glu Gly 
            820                 825                 830         


Asp Lys Phe Thr Ile Arg Leu Glu Lys Met Leu Glu Gly Asp Met Gln 
        835                 840                 845             


Pro Phe Tyr Asn Phe Pro Arg Ile Tyr Glu Val Asn Gly Glu Pro Ala 
    850                 855                 860                 


Glu Ile Asp Gly Ser Ser Leu Asp Gly Lys Thr Leu Lys Ser Arg Tyr 
865                 870                 875                 880 


Gly Asn Ser Val Glu Gln Ser Glu Lys Glu Ile Arg Phe Ile Arg Thr 
                885                 890                 895     


Arg Asp Arg Ile Leu Arg Leu Phe Cys Glu His Ile Leu Glu Thr Tyr 
            900                 905                 910         


Ser Asn Asp Lys Asn Thr Pro Phe His Thr Phe Gln Leu Ser Ser Ile 
        915                 920                 925             


Tyr Pro Ser Ser Glu Thr Ser Pro Leu Asn Arg Pro Phe Ser Phe Lys 
    930                 935                 940                 


Gln Pro Ile Ile Arg Lys Gly Asn Glu Ala Tyr Ile Thr Val Ile Ala 
945                 950                 955                 960 


Arg Asp Thr Glu Gln Gln Leu Lys Glu Val Ser Glu Tyr Ser Leu Leu 
                965                 970                 975     


Thr Thr Asp Glu Glu Lys Asp Ala Phe Thr Gly Gln Lys Gly His Glu 
            980                 985                 990         


Trp Thr Ile Lys Asp Phe Gly Arg  Phe Lys Arg Leu Ser  Ala Asp Arg 
        995                 1000                 1005             


Arg Ile  Pro Ser Leu Ser Asp  Tyr Phe Glu Phe Lys  Glu Val Pro 
    1010                 1015                 1020             


Phe Lys  Leu Leu Glu Tyr Gln  Leu Lys Glu Tyr Asp  Lys Tyr Arg 
    1025                 1030                 1035             


Glu Glu  Ile Phe Asp Ile Thr  Phe Glu Ile Glu Arg  His Ala Cys 
    1040                 1045                 1050             


Asp Val  Ala Leu Glu Asp Ile  Thr Arg Leu Glu Leu  Asn Lys Arg 
    1055                 1060                 1065             


Gln Ala  Asp Gly Ser Lys Asn  Phe Asn Asn Val Gln  Phe Gly Ile 
    1070                 1075                 1080             


Tyr Leu  Gln Trp Ile Gly Asp  Asn Asp Leu Leu Ser  Ser Asp Glu 
    1085                 1090                 1095             


Ile Asn  Arg Leu Arg Asn Ile  Arg Asn Lys Phe Ser  His Ser Glu 
    1100                 1105                 1110             


Phe Pro  Thr Tyr Trp Asp Ala  Ile Pro Lys Ile Thr  Glu Glu Ala 
    1115                 1120                 1125             


Val Ala  Arg Phe Glu Asp Asn  Tyr Arg Ile Ser Gly  Arg Ile Glu 
    1130                 1135                 1140             


Gln Leu  Asp Ile Ser Leu Ser  Lys Leu Ile Ala Glu  Asp Tyr Arg 
    1145                 1150                 1155             


Ser Ile  Ala Asn Lys Ile Leu  Gln Arg Gly Asn Ala  Ser 
    1160                 1165                 1170     


<210>  1493
<211>  1137
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1493

Met Glu Asn Gln Ala Ser Arg Glu Lys Thr Asn Tyr Asn Leu Asn Glu 
1               5                   10                  15      


Thr Pro Trp Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg His Asn Met 
            20                  25                  30          


Phe Val Leu Ile Asn His Leu Thr Glu Lys Phe Lys Tyr Leu Gly Phe 
        35                  40                  45              


Asn Lys Ile Asp Asp Asp Cys Glu Ile Ile Lys Asp Asn Ile Leu Thr 
    50                  55                  60                  


Ser Ile Phe Asn Pro Asn Asn Ser Asn Tyr Glu Ala Glu Arg Phe Lys 
65                  70                  75                  80  


Val Tyr Lys Tyr Leu Val Lys Arg His Tyr Leu Pro Phe Val Lys Ile 
                85                  90                  95      


Phe His Glu Lys Asn Gly Val Gln Leu Asp Ser Asn Pro Ile Val Asp 
            100                 105                 110         


Tyr His Arg Leu Asn Gln Phe Ile Asn Ile Ser Phe Thr His Ile Asn 
        115                 120                 125             


Lys Phe Arg Asn Ser Tyr Thr His Tyr Leu Ala Val Asp Asn Asp Lys 
    130                 135                 140                 


Asn Ile Ile Lys Glu Arg Lys Lys Ala Ile Asp Asn Leu Ile Val Glu 
145                 150                 155                 160 


Asp Leu Lys Lys Leu Phe Lys His Ala Pro Asp Phe Ala Leu Gln Arg 
                165                 170                 175     


Phe Lys Asp Ser Gln Glu Glu Asn Asn Phe Asn His Leu Asp Leu Tyr 
            180                 185                 190         


Ser Ile Leu Glu Asn Asn Lys Leu Thr Glu His Gly Phe Tyr Phe Phe 
        195                 200                 205             


Thr Asn Leu Phe Leu Asn Gln Thr Tyr Ala Ile Gln Phe Leu Lys Lys 
    210                 215                 220                 


Ile Ser Gly Phe Lys Asn Glu Thr Ile Pro Ala Phe Lys Ala Thr Leu 
225                 230                 235                 240 


Gln Thr Phe Thr Ala Tyr Ala Val Lys Thr Pro Asp Ile Arg Leu Asp 
                245                 250                 255     


Asn Asp Asp Arg Asn Gln Ser Leu Leu Leu Glu Met Met Asn Glu Leu 
            260                 265                 270         


Gln Lys Cys Pro Asn Glu Leu Tyr Arg Tyr Leu Ser Glu Glu Asp Gln 
        275                 280                 285             


Lys Lys Phe Gln Pro Thr Leu Asp Thr Asn Ser Lys Thr Asn Phe Ile 
    290                 295                 300                 


Leu Asn Ser Ile Asp Tyr Asn Ala Ile His Asp Asp Asp Ile Asp Ser 
305                 310                 315                 320 


Leu Leu Ser Glu Thr Thr Ser Leu Arg Arg Ser Thr Asn Arg Phe Pro 
                325                 330                 335     


Tyr Phe Ala Leu Arg Phe Leu Glu Glu Asn Asn Phe Leu Asn Asn Ile 
            340                 345                 350         


Arg Phe Gln Ile Asn Ile Gly Lys Leu His Val Arg Ser Tyr Pro Lys 
        355                 360                 365             


Thr Ile Ala His Glu Lys Ile Asn Arg Arg Ile Gln Lys Gln Ile Lys 
    370                 375                 380                 


Gly Phe Gly Lys Leu Ser Asp Phe Glu Asn Lys Glu Ala Glu Val Leu 
385                 390                 395                 400 


Glu Lys Leu Asn Phe Asn Asn Asp Asn Cys Tyr Phe Asp Gln Tyr Ser 
                405                 410                 415     


Pro His Tyr Asn Ile Val Asn Asn Lys Ile Gly Phe Phe Leu Phe Glu 
            420                 425                 430         


Ser Gly Glu Lys Thr Val Ile Gln Lys Glu Gln Lys Leu Val Lys Pro 
        435                 440                 445             


Thr Gly Phe Ile Ser Ile His Asp Leu Pro Lys Ile Val Met Leu Ser 
    450                 455                 460                 


Ile Leu Lys Pro Asn Glu Val Glu Asn Thr Ile Lys Arg Phe Ile Asp 
465                 470                 475                 480 


Ile Asn Thr Ser Asp Ile Leu Asn Ile Ser Lys Leu Asp Ala Ile Lys 
                485                 490                 495     


Ser Asn Leu Thr Leu Thr Pro Val Ala Phe Thr Lys Arg Arg Glu Lys 
            500                 505                 510         


Leu Lys Ser Ile Thr Thr Glu Asn Gly Tyr Glu Phe Leu Asn Asn Asp 
        515                 520                 525             


Ile Glu Arg Lys Ile Phe Ser Glu Asn Lys Leu Asn His Asp Ser Ile 
    530                 535                 540                 


Leu Thr Tyr Glu Asn Lys Lys Ile Asn Lys Lys Asp Lys Glu His Ile 
545                 550                 555                 560 


Ser Gln Ile Lys Tyr Lys Leu Leu Leu Lys Asn Arg Lys Gln Asn Leu 
                565                 570                 575     


Gln Lys Ala Leu Thr Gln Lys Ile Leu Val Asp Gln Leu Pro Gln Lys 
            580                 585                 590         


Val Val Asp Tyr Leu Leu Asn Leu Glu Ser Ile Ala Glu Lys Lys Leu 
        595                 600                 605             


Ile His Ala Lys Ile Lys Ser Ile Lys Asp Glu Ala Lys Ser Lys Leu 
    610                 615                 620                 


Arg Trp Ile Lys Lys Glu Val Glu Leu Pro Lys Glu Asp Gln Lys Ile 
625                 630                 635                 640 


Lys Leu Gly Glu Ile Ala Thr Phe Ile Ala Arg Asp Ile Leu Asn Met 
                645                 650                 655     


Ile Ile Ser Leu Glu Val Lys Glu Lys Phe Thr Ser Ala Tyr Tyr Asn 
            660                 665                 670         


Lys Leu Gln Asn Lys Ile Ala Tyr Phe Ser Gly Ser Lys Lys Glu Ile 
        675                 680                 685             


Ile Ala Met Cys Lys Glu Leu Gln Leu Phe Asn Lys Ile Ile Gly His 
    690                 695                 700                 


Val Phe Leu Thr Lys Asp Gln Ile Glu Gln Ser Lys Gly Ile Ile Asp 
705                 710                 715                 720 


Phe Tyr Gln Thr Tyr Leu Glu Ser Lys Ile Ser Trp Ile Asp Gln Lys 
                725                 730                 735     


Leu Phe Arg Lys Gly Lys Glu Gly Gly Tyr Ile Ile Pro Asp Asn Thr 
            740                 745                 750         


Asn Val Pro Phe Thr Ile Ser Ser Phe Lys Thr Asn Ile Ala Ala Gln 
        755                 760                 765             


Asp Phe Asn Asn Trp Leu Ala Asn Lys Lys Lys Leu Pro Ile Asn Leu 
    770                 775                 780                 


Pro Thr Ser Leu Phe Asp Lys Asn Leu Cys Glu Ser Leu Cys Lys Lys 
785                 790                 795                 800 


Leu Lys Thr Asn Lys Ile Asp Tyr Lys Glu Thr Asp Lys Phe Ser Ile 
                805                 810                 815     


Leu Phe Ala Lys Ser Leu Lys Asn Asp Lys Gln Pro Phe Tyr Asp Phe 
            820                 825                 830         


Lys Arg Val Tyr Glu Cys Ser Gln Thr Gly Glu Ser Val Leu Val Asn 
        835                 840                 845             


Thr Gln Asn Ile His Gly Lys Ala Ile Lys Ser Lys Tyr Gly Lys Arg 
    850                 855                 860                 


Ala Glu Glu Asn Glu Lys Ile Ile Arg Phe Ile Leu Thr Gln Asp Arg 
865                 870                 875                 880 


Val Val Lys Arg Met Cys Glu Phe Ile Leu Ala Gln Asn Thr Thr Glu 
                885                 890                 895     


Asn Leu Gln Leu Asp Leu Ser Ser Phe Ile Pro Leu Ser Asn Gln Thr 
            900                 905                 910         


Pro Leu Asn Ser Ala Phe Ser Phe Lys His Val Ile Asn Leu Glu Lys 
        915                 920                 925             


Gly Lys Met Leu Thr Ile Ile Ala Glu Asp Asn Glu His Gln Arg Ser 
    930                 935                 940                 


Glu Val Glu Glu Phe Asn Lys Leu Thr Ser Val Glu Asp Gln Gln Lys 
945                 950                 955                 960 


Tyr Ser Lys Gln Lys Gly Tyr Gln Trp Thr Met Lys Asp Phe Gly Arg 
                965                 970                 975     


Phe Lys Arg Phe Val Ser Asp Lys Arg Ile Phe Asn Leu Leu Ser Phe 
            980                 985                 990         


Leu Glu Thr Asp Thr Val Thr Phe  Asp Phe Ile Thr Tyr  Gln Phe Arg 
        995                 1000                 1005             


Glu Tyr  Asp Lys Ile Arg Ser  Ala Val Phe Gln Gln  Thr Phe Glu 
    1010                 1015                 1020             


Leu Glu  Glu Tyr Ile Ala Thr  Asn Asp Leu Glu Asn  Leu Ile Asn 
    1025                 1030                 1035             


Glu Glu  Phe Lys Arg Arg Arg  Asp Phe Glu Glu Val  Gln Phe Lys 
    1040                 1045                 1050             


Val Tyr  Leu Lys Val Leu Glu  Asn Lys Thr Asp Ser  Asn Thr Ile 
    1055                 1060                 1065             


Glu Ile  Leu Gln Asn Ile Arg  Asn Lys Phe Ser His  Ser Glu Phe 
    1070                 1075                 1080             


Pro Ile  Leu Asp Glu Lys Glu  Thr Ile Lys Lys Ile  Thr Ser Lys 
    1085                 1090                 1095             


Gln Ile  Asp Thr Phe Glu Lys  Glu Lys His Arg Lys  Gly Gly Val 
    1100                 1105                 1110             


Glu Ser  Leu Asp Leu Ser Ile  Ser Thr Lys Tyr Leu  Ala Leu Tyr 
    1115                 1120                 1125             


Thr Glu  Lys Ile Asn Ser Ile  Ile Lys 
    1130                 1135         


<210>  1494
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1494

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1495
<211>  1135
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1495

Met Asn Thr Val Pro Ala Ser Glu Asn Lys Gly Gln Ser Arg Thr Val 
1               5                   10                  15      


Glu Asp Asp Pro Gln Tyr Phe Gly Leu Tyr Leu Asn Leu Ala Arg Glu 
            20                  25                  30          


Asn Leu Ile Glu Val Glu Ser His Val Arg Ile Lys Phe Gly Lys Lys 
        35                  40                  45              


Lys Leu Asn Glu Glu Ser Leu Lys Gln Ser Leu Leu Cys Asp His Leu 
    50                  55                  60                  


Leu Ser Val Asp Arg Trp Thr Lys Val Tyr Gly His Ser Arg Arg Tyr 
65                  70                  75                  80  


Leu Pro Phe Leu His Tyr Phe Asp Pro Asp Ser Gln Ile Glu Lys Asp 
                85                  90                  95      


His Asp Ser Lys Thr Gly Val Asp Pro Asp Ser Ala Gln Arg Leu Ile 
            100                 105                 110         


Arg Glu Leu Tyr Ser Leu Leu Asp Phe Leu Arg Asn Asp Phe Ser His 
        115                 120                 125             


Asn Arg Leu Asp Gly Thr Thr Phe Glu His Leu Glu Val Ser Pro Asp 
    130                 135                 140                 


Ile Ser Ser Phe Ile Thr Gly Thr Tyr Ser Leu Ala Cys Gly Arg Thr 
145                 150                 155                 160 


Gln Ser Arg Phe Ala Asp Phe Phe Lys Pro Asp Asp Phe Val Leu Ala 
                165                 170                 175     


Lys Asn Arg Lys Glu Gln Leu Ile Ser Val Ala Asp Gly Lys Glu Cys 
            180                 185                 190         


Leu Thr Val Ser Gly Leu Ala Phe Phe Ile Cys Leu Phe Leu Asp Arg 
        195                 200                 205             


Glu Gln Ala Ser Gly Met Leu Ser Arg Ile Arg Gly Phe Lys Arg Thr 
    210                 215                 220                 


Asp Glu Asn Trp Ala Arg Ala Val His Glu Thr Phe Cys Asp Leu Cys 
225                 230                 235                 240 


Ile Arg His Pro His Asp Arg Leu Glu Ser Ser Asn Thr Lys Glu Ala 
                245                 250                 255     


Leu Leu Leu Asp Met Leu Asn Glu Leu Asn Arg Cys Pro Arg Ile Leu 
            260                 265                 270         


Tyr Asp Met Leu Pro Glu Glu Glu Arg Ala Gln Phe Leu Pro Ala Leu 
        275                 280                 285             


Asp Glu Asn Ser Met Asn Asn Leu Ser Glu Asn Ser Leu Asn Glu Glu 
    290                 295                 300                 


Ser Arg Leu Leu Trp Asp Gly Ser Ser Asp Trp Ala Glu Ala Leu Thr 
305                 310                 315                 320 


Lys Arg Ile Arg His Gln Asp Arg Phe Pro Tyr Leu Met Leu Arg Phe 
                325                 330                 335     


Ile Glu Glu Met Asp Leu Leu Lys Gly Ile Arg Phe Arg Val Asp Leu 
            340                 345                 350         


Gly Glu Ile Glu Leu Asp Ser Tyr Ser Lys Lys Val Gly Arg Asn Gly 
        355                 360                 365             


Glu Tyr Asp Arg Thr Ile Thr Asp His Ala Leu Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Asp Phe Gln Asn Glu Glu Glu Val Ser Arg Met Ile Ser Gly Glu 
385                 390                 395                 400 


Ala Ser Tyr Pro Val Arg Phe Ser Leu Phe Ala Pro Arg Tyr Ala Ile 
                405                 410                 415     


Tyr Asp Asn Lys Ile Gly Tyr Cys His Thr Ser Asp Pro Val Tyr Pro 
            420                 425                 430         


Lys Ser Lys Thr Gly Glu Lys Arg Ala Leu Ser Asn Pro Arg Ser Met 
        435                 440                 445             


Gly Phe Ile Ser Val His Asp Leu Arg Lys Leu Leu Leu Met Glu Leu 
    450                 455                 460                 


Leu Cys Glu Gly Ser Phe Ser Arg Met Gln Ser Asp Phe Leu Arg Lys 
465                 470                 475                 480 


Ala Asn Arg Ile Leu Asp Glu Thr Ala Glu Gly Lys Leu Gln Phe Ser 
                485                 490                 495     


Ala Leu Phe Pro Glu Met Arg His Arg Phe Ile Pro Pro Gln Asn Pro 
            500                 505                 510         


Lys Ser Lys Asp Arg Arg Glu Lys Ala Glu Thr Thr Leu Glu Lys Tyr 
        515                 520                 525             


Lys Gln Glu Ile Lys Gly Arg Lys Asp Lys Leu Asn Ser Gln Leu Leu 
    530                 535                 540                 


Ser Ala Phe Asp Met Asp Gln Arg Gln Leu Pro Ser Arg Leu Leu Asp 
545                 550                 555                 560 


Glu Trp Met Asn Ile Arg Pro Ala Ser His Ser Val Lys Leu Arg Thr 
                565                 570                 575     


Tyr Val Lys Gln Leu Asn Glu Asp Cys Arg Leu Arg Leu Gln Lys Phe 
            580                 585                 590         


Arg Lys Asp Gly Asp Gly Lys Ala Arg Ala Ile Pro Leu Val Gly Glu 
        595                 600                 605             


Met Ala Thr Phe Leu Ser Gln Asp Ile Val Arg Met Ile Ile Ser Glu 
    610                 615                 620                 


Glu Thr Lys Lys Leu Ile Thr Ser Ala Tyr Tyr Asn Glu Met Gln Arg 
625                 630                 635                 640 


Ser Leu Ala Gln Tyr Ala Gly Glu Glu Asn Arg His Gln Phe Arg Ala 
                645                 650                 655     


Ile Val Ala Glu Leu Arg Leu Leu Asp Pro Ser Ser Gly His Pro Phe 
            660                 665                 670         


Leu Ser Ala Thr Met Glu Thr Ala His Arg Tyr Thr Glu Asp Phe Tyr 
        675                 680                 685             


Lys Cys Tyr Leu Glu Lys Lys Arg Glu Trp Leu Ala Lys Thr Phe Tyr 
    690                 695                 700                 


Arg Pro Glu Gln Asp Glu Asn Thr Lys Arg Arg Ile Ser Val Phe Phe 
705                 710                 715                 720 


Val Pro Asp Gly Glu Ala Arg Lys Leu Leu Pro Leu Leu Ile Arg Arg 
                725                 730                 735     


Arg Met Lys Glu Gln Asn Asp Leu Gln Asp Trp Ile Arg Asn Lys Gln 
            740                 745                 750         


Ala His Pro Ile Asp Leu Pro Ser His Leu Phe Asp Ser Lys Val Met 
        755                 760                 765             


Glu Leu Leu Lys Val Lys Asp Gly Lys Lys Lys Trp Asn Glu Ala Phe 
    770                 775                 780                 


Lys Asp Trp Trp Ser Thr Lys Tyr Pro Asp Gly Met Gln Pro Phe Tyr 
785                 790                 795                 800 


Gly Leu Arg Arg Glu Leu Asn Ile His Gly Lys Ser Val Ser Tyr Ile 
                805                 810                 815     


Pro Ser Asp Gly Lys Lys Phe Ala Asp Cys Tyr Thr His Leu Met Glu 
            820                 825                 830         


Lys Thr Val Arg Asp Lys Lys Arg Glu Leu Arg Thr Ala Gly Lys Pro 
        835                 840                 845             


Val Pro Pro Asp Leu Ala Ala Tyr Ile Lys Arg Ser Phe His Arg Ala 
    850                 855                 860                 


Val Asn Glu Arg Glu Phe Met Leu Arg Leu Val Gln Glu Asp Asp Arg 
865                 870                 875                 880 


Leu Met Leu Met Ala Ile Asn Lys Ile Met Thr Asp Arg Glu Glu Asp 
                885                 890                 895     


Ile Leu Pro Gly Leu Lys Asn Ile Asp Ser Ile Leu Asp Lys Glu Asn 
            900                 905                 910         


Gln Phe Ser Leu Ala Val His Ala Lys Val Leu Glu Lys Glu Gly Glu 
        915                 920                 925             


Gly Gly Asp Asn Ser Leu Ser Leu Val Pro Ala Thr Ile Glu Ile Lys 
    930                 935                 940                 


Ser Lys Arg Lys Asp Trp Ser Lys Tyr Ile Arg Tyr Arg Tyr Asp Arg 
945                 950                 955                 960 


Arg Val Pro Gly Leu Met Ser His Phe Pro Glu His Lys Ala Thr Leu 
                965                 970                 975     


Asp Glu Val Lys Thr Leu Leu Gly Glu Tyr Asp Arg Cys Arg Ile Lys 
            980                 985                 990         


Ile Phe Asp Trp Ala Phe Ala Leu  Glu Gly Ala Ile Met  Ser Asp Arg 
        995                 1000                 1005             


Asp Leu  Lys Pro Tyr Leu His  Glu Ser Ser Ser Arg  Glu Gly Lys 
    1010                 1015                 1020             


Ser Gly  Glu His Ser Thr Leu  Val Lys Met Leu Val  Glu Lys Lys 
    1025                 1030                 1035             


Gly Cys  Leu Thr Pro Asp Glu  Ser Gln Tyr Leu Ile  Leu Ile Arg 
    1040                 1045                 1050             


Asn Lys  Ala Ala His Asn Gln  Phe Pro Cys Ala Ala  Glu Ile Pro 
    1055                 1060                 1065             


Leu Ile  Tyr Arg Asp Val Ser  Ala Lys Val Gly Ser  Ile Glu Gly 
    1070                 1075                 1080             


Ser Ser  Ala Lys Asp Leu Pro  Glu Gly Ser Ser Leu  Val Asp Ser 
    1085                 1090                 1095             


Leu Trp  Lys Lys Tyr Glu Met  Ile Ile Arg Lys Ile  Leu Pro Ile 
    1100                 1105                 1110             


Leu Asp  Pro Glu Asn Arg Phe  Phe Gly Lys Leu Leu  Asn Asn Met 
    1115                 1120                 1125             


Ser Gln  Pro Ile Asn Asp Leu  
    1130                 1135 


<210>  1496
<211>  1175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1496

Met Thr Glu Gln Asn Glu Lys Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Phe Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Ala His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Cys Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Glu Lys Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Ala Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Phe Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Asp Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Gly Glu Ile Asp Thr Leu Asp 
    530                 535                 540                 


Arg Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Met Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Gly Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Tyr Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Trp Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Asp Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Asp Leu Glu Ala Trp Ser His Ser Ala Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Ala Gly Ile Glu Tyr Ala Ser Pro Gly Asn 
    850                 855                 860                 


Lys Lys Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Glu Thr 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Lys Ala Asp Lys Ile Asn Ile Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Ala Gln Glu His Pro Tyr Leu Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asp Ile Arg Thr 
945                 950                 955                 960 


Glu Val Gln Glu Gln Gly Ser Leu Asn Val Leu Asn Arg Val Lys Pro 
                965                 970                 975     


Met Arg Leu Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val 
            980                 985                 990         


His Lys Glu Gln Ala Pro Leu Ala  Thr Val Tyr Ile Glu  Glu Arg Asp 
        995                 1000                 1005             


Thr Lys  Leu Leu Lys Gln Gly  Asn Phe Lys Ser Phe  Val Lys Asp 
    1010                 1015                 1020             


Arg Arg  Leu Asn Gly Leu Phe  Ser Phe Val Asp Thr  Gly Gly Leu 
    1025                 1030                 1035             


Ala Met  Glu Gln Tyr Pro Ile  Ser Lys Leu Arg Val  Glu Tyr Glu 
    1040                 1045                 1050             


Leu Ala  Lys Tyr Gln Thr Ala  Arg Val Cys Val Phe  Glu Gln Thr 
    1055                 1060                 1065             


Leu Glu  Leu Glu Glu Ser Leu  Leu Thr Arg Cys Pro  His Leu Pro 
    1070                 1075                 1080             


Asp Lys  Asn Phe Arg Lys Met  Leu Glu Ser Trp Ser  Asp Pro Leu 
    1085                 1090                 1095             


Leu Asp  Lys Trp Pro Asp Leu  His Gly Asn Val Arg  Leu Leu Ile 
    1100                 1105                 1110             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1115                 1120                 1125             


Glu Ala  Val Phe Ser Ser Ile  Arg Lys Tyr Asp Pro  Ser Ser Leu 
    1130                 1135                 1140             


Asp Ala  Ile Glu Glu Arg Met  Gly Leu Asn Ile Ala  His Arg Leu 
    1145                 1150                 1155             


Ser Glu  Glu Val Lys Gln Ala  Lys Glu Met Val Glu  Arg Ile Ile 
    1160                 1165                 1170             


Gln Val  
    1175 


<210>  1497
<211>  1184
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1497

Met Glu Arg Ile Phe Gly His Cys Cys Pro His His Asp Ser Val Cys 
1               5                   10                  15      


Phe Val Arg Phe Leu Gly Thr Met Val Ser Asn Gln Asp Gly Arg Glu 
            20                  25                  30          


Asn Val Leu Asp Ile Leu Tyr Ile Ala Asp Arg Thr Arg Lys Leu Lys 
        35                  40                  45              


Pro Met Asn Thr Val Pro Ala Ser Glu Asn Lys Gly Gln Ser Arg Thr 
    50                  55                  60                  


Val Glu Asp Asp Pro Gln Tyr Phe Gly Leu Tyr Leu Asn Leu Ala Arg 
65                  70                  75                  80  


Glu Asn Leu Ile Glu Val Glu Ser His Val Arg Ile Lys Phe Gly Lys 
                85                  90                  95      


Lys Lys Leu Asn Glu Glu Ser Leu Lys Gln Ser Leu Leu Cys Asp His 
            100                 105                 110         


Leu Leu Ser Val Asp Arg Trp Thr Lys Val Tyr Gly His Ser Arg Arg 
        115                 120                 125             


Tyr Leu Pro Phe Leu His Tyr Phe Asp Pro Asp Ser Gln Ile Glu Lys 
    130                 135                 140                 


Asp His Asp Ser Lys Thr Gly Val Asp Pro Asp Ser Ala Gln Arg Leu 
145                 150                 155                 160 


Ile Arg Glu Leu Tyr Ser Leu Leu Tyr Phe Leu Arg Asn Asp Phe Ser 
                165                 170                 175     


His Asn Arg Leu Asp Gly Thr Thr Phe Glu His Leu Glu Val Ser Pro 
            180                 185                 190         


Asp Ile Ser Ser Phe Ile Thr Gly Thr Tyr Ser Leu Ala Cys Gly Arg 
        195                 200                 205             


Ala Gln Ser Arg Phe Ala Asp Phe Phe Lys Pro Asp Asp Phe Val Leu 
    210                 215                 220                 


Ala Lys Asn Arg Lys Glu Gln Leu Ile Ser Val Ala Asp Gly Lys Glu 
225                 230                 235                 240 


Cys Leu Thr Val Arg Gly Leu Ala Phe Phe Ile Cys Leu Phe Leu Asp 
                245                 250                 255     


Arg Glu Gln Ala Ser Gly Met Leu Ser Arg Ile Arg Gly Phe Lys Arg 
            260                 265                 270         


Thr Asp Glu Asn Trp Ala Arg Ala Val His Glu Thr Phe Cys Asp Leu 
        275                 280                 285             


Cys Ile Arg His Pro His Asp Arg Leu Glu Ser Ser Asn Thr Lys Glu 
    290                 295                 300                 


Ala Leu Leu Leu Asp Met Leu Asn Glu Leu Asn Arg Cys Pro Arg Ile 
305                 310                 315                 320 


Leu Tyr Asp Met Leu Pro Glu Glu Glu Arg Ala Gln Phe Leu Pro Ala 
                325                 330                 335     


Leu Asp Glu Asn Ser Met Asn Asn Leu Ser Glu Asn Ser Leu Asn Glu 
            340                 345                 350         


Glu Ser Arg Leu Leu Trp Asp Gly Ser Ser Asp Trp Ala Glu Ala Leu 
        355                 360                 365             


Thr Lys Arg Ile Arg His Gln Asp Arg Phe Pro Tyr Leu Met Leu Arg 
    370                 375                 380                 


Phe Ile Glu Glu Met Asp Leu Leu Lys Gly Ile Arg Phe Arg Val Asp 
385                 390                 395                 400 


Leu Gly Glu Ile Glu Leu Asp Ser Tyr Ser Lys Lys Val Gly Arg Asn 
                405                 410                 415     


Gly Glu Tyr Asp His Thr Ile Thr Asp His Ala Leu Ala Phe Gly Lys 
            420                 425                 430         


Leu Ser Asp Phe Gln Asn Glu Glu Glu Val Ser Arg Met Ile Ser Gly 
        435                 440                 445             


Glu Ala Ser Tyr Pro Val Arg Phe Ser Leu Phe Ala Pro Arg Tyr Ala 
    450                 455                 460                 


Ile Tyr Asp Asn Lys Ile Gly Tyr Cys His Thr Ser Asp Pro Val Tyr 
465                 470                 475                 480 


Pro Lys Ser Lys Thr Gly Glu Lys Arg Ala Leu Ser Asn Pro Arg Ser 
                485                 490                 495     


Met Gly Phe Ile Ser Val His Asp Leu Arg Lys Leu Leu Leu Met Glu 
            500                 505                 510         


Leu Leu Cys Glu Gly Ser Phe Ser Arg Met Gln Ser Gly Phe Leu Arg 
        515                 520                 525             


Lys Ala Asn Arg Ile Leu Asp Glu Thr Ala Glu Gly Lys Leu Gln Phe 
    530                 535                 540                 


Ser Ala Leu Phe Pro Glu Met Arg His Arg Phe Ile Pro Pro Gln Asn 
545                 550                 555                 560 


Pro Lys Ser Lys Asp Arg Arg Glu Lys Ala Glu Thr Thr Leu Glu Lys 
                565                 570                 575     


Tyr Lys Gln Glu Ile Lys Gly Arg Lys Asp Lys Leu Asn Ser Gln Leu 
            580                 585                 590         


Leu Ser Ala Phe Asp Met Asp Gln Arg Gln Leu Pro Ser Arg Leu Leu 
        595                 600                 605             


Asp Glu Trp Met Asn Ile Arg Pro Ala Ser His Ser Val Lys Leu Arg 
    610                 615                 620                 


Thr Tyr Val Lys Gln Leu Asn Glu Asp Cys Arg Leu Arg Leu Arg Lys 
625                 630                 635                 640 


Phe Arg Lys Asp Gly Asp Gly Lys Ala Arg Ala Ile Pro Leu Val Gly 
                645                 650                 655     


Glu Met Ala Thr Phe Leu Ser Gln Asp Ile Val Arg Met Ile Ile Ser 
            660                 665                 670         


Glu Glu Thr Lys Lys Leu Ile Thr Ser Ala Tyr Tyr Asn Glu Met Gln 
        675                 680                 685             


Arg Ser Leu Ala Gln Tyr Ala Gly Glu Glu Asn Arg Arg Gln Phe Arg 
    690                 695                 700                 


Ala Ile Val Ala Glu Leu Arg Leu Leu Asp Pro Ser Ser Gly His Pro 
705                 710                 715                 720 


Phe Leu Ser Ala Thr Met Glu Thr Ala His Arg Tyr Thr Glu Asp Phe 
                725                 730                 735     


Tyr Lys Cys Tyr Leu Glu Lys Lys Arg Glu Trp Leu Ala Lys Thr Phe 
            740                 745                 750         


Tyr Arg Pro Glu Gln Asp Glu Asn Thr Lys Arg Arg Ile Ser Val Phe 
        755                 760                 765             


Phe Val Pro Asp Gly Glu Ala Arg Lys Leu Leu Pro Leu Leu Ile Arg 
    770                 775                 780                 


Arg Arg Met Lys Glu Gln Asn Asp Leu Gln Asp Trp Ile Arg Asn Lys 
785                 790                 795                 800 


Gln Ala His Pro Ile Asp Leu Pro Ser His Leu Phe Asp Ser Lys Ile 
                805                 810                 815     


Met Glu Leu Leu Lys Val Lys Asp Gly Lys Lys Lys Trp Asn Glu Ala 
            820                 825                 830         


Phe Lys Asp Trp Trp Ser Thr Lys Tyr Pro Asp Gly Met Gln Pro Phe 
        835                 840                 845             


Tyr Gly Leu Arg Arg Glu Leu Asn Ile His Gly Lys Ser Val Ser Tyr 
    850                 855                 860                 


Ile Pro Ser Asp Gly Lys Lys Phe Ala Asp Cys Tyr Thr His Leu Met 
865                 870                 875                 880 


Glu Lys Thr Val Arg Asp Lys Lys Arg Glu Leu Arg Thr Ala Gly Lys 
                885                 890                 895     


Pro Val Pro Pro Asp Leu Ala Ala Asp Ile Lys Arg Ser Phe His Arg 
            900                 905                 910         


Ala Val Asn Glu Arg Glu Phe Met Leu Arg Leu Val Gln Glu Asp Asp 
        915                 920                 925             


Arg Leu Met Leu Met Ala Ile Asn Lys Met Met Thr Asp Arg Glu Glu 
    930                 935                 940                 


Asp Ile Leu Pro Gly Leu Lys Asn Ile Asp Ser Ile Leu Asp Lys Glu 
945                 950                 955                 960 


Asn Gln Phe Ser Leu Ala Val His Ala Lys Val Leu Glu Lys Glu Gly 
                965                 970                 975     


Glu Gly Gly Asp Asn Ser Leu Ser Leu Val Pro Ala Thr Ile Glu Ile 
            980                 985                 990         


Lys Ser Lys Arg Lys Asp Trp Ser  Lys Tyr Ile Arg Tyr  Arg Tyr Asp 
        995                 1000                 1005             


Arg Arg  Val Pro Gly Leu Met  Ser His Phe Pro Glu  His Lys Ala 
    1010                 1015                 1020             


Thr Leu  Asp Glu Val Lys Thr  Leu Leu Gly Glu Tyr  Asp Arg Cys 
    1025                 1030                 1035             


Arg Ile  Lys Ile Phe Asp Trp  Ala Phe Ala Leu Glu  Gly Ala Ile 
    1040                 1045                 1050             


Met Ser  Asp Arg Asp Leu Lys  Pro Tyr Leu His Glu  Ser Ser Ser 
    1055                 1060                 1065             


Arg Glu  Gly Lys Ser Gly Glu  His Ser Thr Leu Val  Lys Met Leu 
    1070                 1075                 1080             


Val Glu  Lys Lys Gly Cys Leu  Thr Pro Asp Glu Ser  Gln Tyr Leu 
    1085                 1090                 1095             


Ile Leu  Ile Arg Asn Lys Ala  Ala His Asn Gln Phe  Pro Cys Ala 
    1100                 1105                 1110             


Ala Glu  Met Pro Leu Ile Tyr  Arg Asp Val Ser Ala  Lys Val Gly 
    1115                 1120                 1125             


Ser Ile  Glu Gly Ser Ser Ala  Lys Asp Leu Pro Glu  Gly Ser Ser 
    1130                 1135                 1140             


Leu Val  Asp Ser Leu Trp Lys  Lys Tyr Glu Met Ile  Ile Arg Lys 
    1145                 1150                 1155             


Ile Leu  Pro Ile Leu Asp Pro  Glu Asn Arg Phe Phe  Gly Lys Leu 
    1160                 1165                 1170             


Leu Asn  Asn Met Ser Gln Pro  Ile Asn Asp Leu 
    1175                 1180                 


<210>  1498
<211>  1140
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1498

Met Glu Asn Asp Gln Gln Ile Leu Glu Asn Arg Arg Arg Thr Leu Ala 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Ser Asn His Leu Ala Ala Ser Phe Glu Gln Lys Val 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ala Ser Phe Leu Cys Asn Lys Ser 
    50                  55                  60                  


Ile Lys Lys Ile Asn Trp Asn His Val Tyr Ser Lys Ala Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ala Asp Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Arg Glu Thr Thr Asp Lys Glu Gly Lys Asp Phe Thr Ala Met Asn Glu 
            100                 105                 110         


Thr Leu Lys Leu Val Phe Asp Glu Leu Gln Ala Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Ala Asp Ser Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Val Glu Leu Ala Asp Phe Leu Thr Val Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Ala Asp Asp Asp Tyr 
                165                 170                 175     


Thr Met Val Glu Ser Lys Gln Ile Val Thr Pro Asp Asn Leu Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Val Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Leu Ala Tyr Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asp Leu Gly Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Glu 
            260                 265                 270         


Val Ile Thr Glu Glu Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Glu Glu Glu Arg 
    290                 295                 300                 


Glu Lys Ile Leu Asp Glu Ile Asp Tyr Glu Asp Tyr Ile Glu Ser Leu 
305                 310                 315                 320 


Thr Arg Arg Val Arg His Ser Asn Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Lys Tyr Asn Lys Gln Phe Asp Gly Glu 
        355                 360                 365             


Ala Thr Glu Cys Lys Val Val Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asn Gln Glu Thr Val Glu Leu Lys Ile Asp Ser Ala 
385                 390                 395                 400 


Gln Arg Thr Asn Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Glu Ala Arg Leu Leu 
            420                 425                 430         


Thr Lys Ala Lys Pro Glu Ser Lys Val Ser Tyr Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Lys Ala Glu Glu Met Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Lys Val Asn Asp Ser Gln Leu Met Ser Met Gln Phe Ile Asp Glu 
                485                 490                 495     


Ile Lys Glu Gln Leu Pro Ala Asp Trp Asn Glu Phe Gly Lys Arg Ser 
            500                 505                 510         


Asp Ser Lys Lys Lys Lys Ala Tyr Thr Asn Ala Ala Leu Gln Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Lys Val Leu Ala Asn Tyr Gln Leu 
    530                 535                 540                 


Asn Asp Lys Gln Val Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Ser Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Val Glu Lys His Lys Leu 
            580                 585                 590         


Asp Lys Ser Ala Arg Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Thr Asp Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Phe Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Tyr 
625                 630                 635                 640 


Ala Asp Thr Asp Lys Lys Ala Thr Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Lys Gly Gly His Pro Phe Leu Ala Asn Ile Asn 
            660                 665                 670         


Leu Arg Gln Ile Arg Lys Thr Ser Gln Leu Tyr Glu Leu Tyr Leu Val 
        675                 680                 685             


Glu Lys Ala Asn Lys Gln Val Lys Lys Met Asn Pro Lys Thr Gln Arg 
    690                 695                 700                 


Thr Ser Asn Val Asp Glu Ser Trp Met Met Lys Ser Phe Tyr Ala Lys 
705                 710                 715                 720 


Glu Trp Asn Glu Glu Met Gly Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Val Asn Lys Thr Asn Ile Pro Phe Thr Ile Arg Gln Trp Glu Glu Lys 
            740                 745                 750         


Glu Lys His Asn Leu Gln Ala Trp Leu His Asn Ile Thr Lys Gly Lys 
        755                 760                 765             


Thr Ser Lys Asp Gly Lys Lys Ala Ile Asp Leu Pro Thr Asn Leu Phe 
    770                 775                 780                 


Asp Asp Thr Leu Cys Glu Leu Leu Arg Glu Ala Leu Ile Asn Gln Gly 
785                 790                 795                 800 


Ile Asp Ala Thr Pro Thr Thr Lys Tyr Asn Glu Leu Leu Lys Gln Trp 
                805                 810                 815     


Trp Thr Ala Arg Glu Asp Ser Thr Gln Asp Phe Tyr Leu Ser Glu Arg 
            820                 825                 830         


Gln Tyr Asp Ile Tyr Asp Glu Lys Val Cys Phe Thr Ile Asn Ser Ser 
        835                 840                 845             


Ala His Phe Ala Asp Tyr Tyr Ala Pro Ala Leu Asn Lys Ala Tyr Ser 
    850                 855                 860                 


Arg Leu Arg Ala Glu Arg Asp Val Ala Arg Arg Thr Asp Lys Arg Leu 
865                 870                 875                 880 


Pro Pro Val Glu Arg Lys Asp Val Glu Arg Val Phe Lys Asn Thr Ile 
                885                 890                 895     


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
            900                 905                 910         


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asn Gln Gln Gln Leu Lys 
        915                 920                 925             


Leu Ser Lys Met Asp Ser Leu Leu Asn Glu Thr Lys Arg Ile Glu Gln 
    930                 935                 940                 


Thr Ile Asn Thr Gln Leu Ser Phe Asp His Lys Gly Lys Glu Ile Lys 
945                 950                 955                 960 


Asp Lys Thr Asn Ser Glu Ile Val Lys Thr Ile Val Ala Glu Arg Lys 
                965                 970                 975     


Gln Lys Asn Tyr Thr Glu Met Arg Lys Tyr Val His Asp Arg Arg Leu 
            980                 985                 990         


Pro Glu Leu Phe Glu Tyr Ile Asp  Gly Asn Glu Leu Pro  Leu Asp Val 
        995                 1000                 1005             


Leu Leu  Asn Glu Leu Arg Ala  Tyr Asn Thr Ala Lys  Gln Met Val 
    1010                 1015                 1020             


Phe Asp  Thr Val Phe Ala Leu  Glu Lys Lys Ile Ile  Glu Thr Asp 
    1025                 1030                 1035             


Pro Glu  Gly Leu Lys Gln Leu  Asn Val Gly Lys Asn  Gly Gln Ile 
    1040                 1045                 1050             


Gln Thr  Gly Asn Ile Gln His  Lys Pro Tyr Val Gln  Trp Leu Glu 
    1055                 1060                 1065             


Asn Lys  Gly Leu Ile Thr Asp  His Gln Lys Gln Phe  Ile Asn Met 
    1070                 1075                 1080             


Val Arg  Asn Ser Phe Ser His  Asn Gln Phe Pro Gln  Arg Ser Thr 
    1085                 1090                 1095             


Val Glu  Leu Leu Met Pro Glu  Trp Gln Asn Thr Asp  Ile Ala Leu 
    1100                 1105                 1110             


Gln Ile  Ala Arg Glu Tyr Gln  Gln Leu Ile Val Asp  Ile Ile Glu 
    1115                 1120                 1125             


Lys Ser  Leu His Pro His Lys  Gln His Gln Met Val  
    1130                 1135                 1140 


<210>  1499
<211>  985
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1499

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Lys His Leu 
145                 150                 155                 160 


Arg Asn Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys Gly Tyr 
                165                 170                 175     


Ala Phe Phe Ile Ser Lys Phe Leu Glu Arg Lys Tyr Ser Tyr Leu Phe 
            180                 185                 190         


Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln Tyr Arg 
        195                 200                 205             


Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro Val Glu 
    210                 215                 220                 


Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu Asp Ile 
225                 230                 235                 240 


Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr Leu Glu 
                245                 250                 255     


Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr Asp Ala 
            260                 265                 270         


Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe Arg Ser 
        275                 280                 285             


Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala Asp Phe 
    290                 295                 300                 


Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His Asn Gly 
305                 310                 315                 320 


Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr Ile Asn 
                325                 330                 335     


Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser Ala Lys 
            340                 345                 350         


Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser Thr Asp 
        355                 360                 365             


Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln Ser Thr 
    370                 375                 380                 


Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val Leu Pro 
385                 390                 395                 400 


Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala Lys Met 
                405                 410                 415     


Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala Met Leu 
            420                 425                 430         


Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His Cys Pro 
        435                 440                 445             


Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser Thr Lys 
    450                 455                 460                 


Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg Val Met 
465                 470                 475                 480 


Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu Arg Ile 
                485                 490                 495     


Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile Leu Lys 
            500                 505                 510         


Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp Leu Gln 
        515                 520                 525             


Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn Phe Gln 
    530                 535                 540                 


Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn Asp Leu 
545                 550                 555                 560 


Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn Pro His 
                565                 570                 575     


Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile Glu Phe 
            580                 585                 590         


Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg Ile Gln 
        595                 600                 605             


Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro Leu Arg 
    610                 615                 620                 


Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu Ala Ile 
625                 630                 635                 640 


Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys Leu Lys 
                645                 650                 655     


Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu Lys Ser 
            660                 665                 670         


Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg Thr Tyr 
        675                 680                 685             


Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn Tyr Arg 
    690                 695                 700                 


Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser Tyr Leu 
705                 710                 715                 720 


Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro Ser Lys 
                725                 730                 735     


Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp Arg Leu 
            740                 745                 750         


Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile Ile Arg 
        755                 760                 765             


Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys Glu Tyr 
    770                 775                 780                 


Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu Glu Asn 
785                 790                 795                 800 


Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp Leu Asn 
                805                 810                 815     


Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr Gly Lys 
            820                 825                 830         


Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn Lys Val 
        835                 840                 845             


Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val Lys Ile 
    850                 855                 860                 


Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu Glu Ala 
865                 870                 875                 880 


Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala Met Val 
                885                 890                 895     


Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr Tyr Asp 
            900                 905                 910         


Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln Lys Ile 
        915                 920                 925             


Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His Asp Lys 
    930                 935                 940                 


Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Leu Val Tyr Ala 
945                 950                 955                 960 


Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile Lys Leu 
                965                 970                 975     


Glu Asp Leu Ser Asn Asp Ser Ser Ala 
            980                 985 


<210>  1500
<211>  1129
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1500

Met Glu Thr Asn Gln Gln Thr His Glu Asn Arg Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Asn Asn His Val Ala Thr Asp Phe Lys Arg Lys Pro 
        35                  40                  45              


Leu Pro Glu Glu Gly His Ile Pro Asp Ala Leu Leu Cys Asn Lys Thr 
    50                  55                  60                  


Ile Lys Asn Leu Asn Trp Asn His Val His Thr Arg Ala Leu Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ser Glu Ser Leu Pro Lys Asp Glu 
                85                  90                  95      


Arg Glu Asn Ser Asp Thr Glu Gly Lys Asp Phe Thr Ser Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Ser Glu Leu Gln Asp Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Asp Ser Arg Lys Leu Ile Val 
    130                 135                 140                 


Ser Pro Glu Leu Ala Asn Phe Leu Thr Val Asn Phe Gln Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Ala Arg Met Lys Asp Val Leu Thr Asp Thr Asp Tyr 
                165                 170                 175     


Ala Leu Val Glu Asn Leu Gln Met Val Ala Pro Asp Asn Lys Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ala Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Thr Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asn Leu Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Ser 
            260                 265                 270         


Val Ile Thr Asp Lys Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Asp Asp Glu Arg 
    290                 295                 300                 


Glu Thr Ile Leu Asp Glu Ile Asp Tyr Gln Asp Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg Tyr Ser Asp Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Asp Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Asn Tyr Thr Lys Gln Phe Ala Gly Glu 
        355                 360                 365             


Gln Ala Glu Arg Lys Val Leu Glu Asn Ala Asn Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asp Pro Glu Leu Ile Gln Gln Arg Ile Asp Lys Gln 
385                 390                 395                 400 


Gln His Thr Ala Gly Phe Asp Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Thr Lys Glu Asn Ile Ala Thr Leu Ile 
            420                 425                 430         


Ala Lys Ser Lys Ala Ser Ser Lys Val Glu His Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Gln Ala Glu Glu Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Ile Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Ser Gln Leu Pro Ala Asn Trp Asp Glu Phe Ser Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asp Ser Thr Leu Lys Tyr Leu 
        515                 520                 525             


Arg Gln Arg Lys Thr Thr Leu Asn Thr Ile Leu Ser Lys Ser Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Lys Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Thr Arg Leu Lys Ala Val Glu Lys His Lys Leu 
            580                 585                 590         


Asn Lys Ser Val Lys Ile Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Glu Glu Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Ala Asn Ala Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Phe Glu Asn Gly Gly His Pro Phe Leu Gln Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Gln Ala Tyr Leu Val 
        675                 680                 685             


Glu Lys Gly Asn Lys Met Val Pro Arg Leu Asn Pro Lys Thr Asn Lys 
    690                 695                 700                 


Thr Ser Lys Val Asp Glu Ser Trp Met Met Lys Gln Phe Tyr Val Lys 
705                 710                 715                 720 


Glu Trp Lys Glu Glu Ile Ala Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Ser Arg Ile Pro Phe Thr Ile Arg Gln Trp Asp Glu Lys 
            740                 745                 750         


Glu Lys Tyr Asp Leu Asn Val Trp Leu Gln His Val Thr Val Gly Lys 
        755                 760                 765             


Asn Lys Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe Asp 
    770                 775                 780                 


Glu Ala Leu Cys Asn Leu Leu Arg Glu Gln Leu Asp Thr Lys Ile Val 
785                 790                 795                 800 


Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Ile Trp Trp 
                805                 810                 815     


Lys Thr Arg Asn Asp Asp Thr Gln Gln Phe Tyr Gln Ser Glu Arg Glu 
            820                 825                 830         


Tyr Asp Ile Tyr Asn Glu Lys Val Arg Phe Lys Ile Asp Ser Ser Thr 
        835                 840                 845             


His Phe Ala Asp Tyr Tyr Lys Asn Ala Leu Ser Arg Ala Tyr Thr Arg 
    850                 855                 860                 


Leu Lys Ala Glu Arg Glu Thr Ala Arg Gln Thr Asn Lys Arg Leu Pro 
865                 870                 875                 880 


Pro Leu Glu Tyr Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile Ala 
                885                 890                 895     


Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met Ala 
            900                 905                 910         


Val Leu Met Leu Glu Gln Leu Met Asp Asn Ser Pro Asn Leu Arg Leu 
        915                 920                 925             


Ser Lys Ile Glu Thr Leu Leu Asn Asp Thr Thr Pro Ile Ser Glu Lys 
    930                 935                 940                 


Ile Ser Ala Lys Leu Ser Phe Asp Ala Ser Gly Glu Arg Ile Thr Asp 
945                 950                 955                 960 


Lys Ser Asn Pro Thr Ala Thr Lys Thr Leu Val Ala Glu Arg Lys Gln 
                965                 970                 975     


Lys Asn Tyr Thr Glu Leu Gln Lys Tyr Arg Tyr Asp Arg Arg Leu Pro 
            980                 985                 990         


Glu Leu Phe Glu Tyr Val Gln Ala  Asp Glu Ile Pro Leu  Glu Trp Leu 
        995                 1000                 1005             


Leu Asp  Glu Leu Ser Ala Tyr  Asn Ser Ala Lys Gln  Gln Val Phe 
    1010                 1015                 1020             


Asp Thr  Val Phe Ala Leu Glu  Lys Lys Ile Ile Gln  Thr Glu Pro 
    1025                 1030                 1035             


Asp Glu  Leu Lys Ser Leu Phe  Thr Gly Ala Asn Gly  Glu Leu Gln 
    1040                 1045                 1050             


Thr Gly  Asn Ile Gln His Lys  Pro Tyr Val Gln Trp  Leu Thr Asn 
    1055                 1060                 1065             


Lys Gly  Leu Ile Asn Lys Glu  Glu Lys Gln Phe Ile  Asn Met Val 
    1070                 1075                 1080             


Arg Lys  Cys Phe Ser His Asn  Gln Phe Pro Gln Arg  Thr Thr Met 
    1085                 1090                 1095             


Glu Leu  Leu Ile Pro Ala Trp  Asn Glu Lys Lys Leu  Ala Leu Gln 
    1100                 1105                 1110             


Ile Ala  Thr Val Tyr Asn Gln  Leu Ile Ala Asp Leu  Thr Asp Lys 
    1115                 1120                 1125             


Ile 
    


<210>  1501
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1501

Met Glu Thr Lys Gln Gln Val Gly Lys Gly Ile Ser Tyr Asp His Arg 
1               5                   10                  15      


Arg Pro Asp Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asp Gly Val Ile Gln Glu Phe Ala Met Arg Leu Asn Arg 
        35                  40                  45              


Glu Tyr Asp Pro Glu Asn Lys Asn Gln Ser Leu Phe Ser Tyr Phe Asn 
    50                  55                  60                  


Ile Asn Ala Ser Phe Thr Asp Trp Glu Arg Gly Val Asn Ile Leu Lys 
65                  70                  75                  80  


Glu Tyr Trp Pro Met Met Glu Phe Ile Asp Arg Pro Ala Thr Asp Lys 
                85                  90                  95      


Gln Phe Glu Ala Glu Lys Pro Glu Asn Arg Glu Ala Ala Lys Arg Lys 
            100                 105                 110         


Tyr Phe Leu Ala Thr Leu Gly Ala Leu Leu Thr Ser Ile Lys Asp Leu 
        115                 120                 125             


Arg His Tyr Tyr Thr His Tyr Tyr His Pro Pro Val His Leu Asn Asp 
    130                 135                 140                 


Asp Leu Phe Leu Phe Leu Asp His Ala Leu Leu Tyr Thr Ala Phe Asp 
145                 150                 155                 160 


Val Lys Lys Thr Lys Met Lys Asp Asp Lys Thr Arg Gln Leu Leu Asn 
                165                 170                 175     


Gln Asn Leu Ser Leu Glu Leu Glu Lys Leu Lys Lys Leu Lys Val Glu 
            180                 185                 190         


Glu Leu Lys Lys Lys Lys Glu Lys Gly Ile Lys Val Asn Leu Gln Asp 
        195                 200                 205             


Glu Lys Gly Ile Leu Asn Ala Ile Tyr Asn Asp Ala Phe Ala His Ile 
    210                 215                 220                 


Ile Thr Lys Glu Lys Asp Ser Asp Lys Asp Lys Leu Glu Thr Arg Tyr 
225                 230                 235                 240 


Lys Ser Ile Leu Pro Gln Asp Glu Ala Ala Glu Thr Gly Ile Asn Ile 
                245                 250                 255     


Ser Ile Ser Gly Leu Ile Phe Leu Leu Ser Leu Phe Leu Ser Arg Lys 
            260                 265                 270         


Glu Ile Glu Gln Leu Lys Ser Asn Ile Glu Gly Tyr Lys Gly Lys Val 
        275                 280                 285             


Leu Asn Ile Glu Thr Glu Val Asp Arg Lys His Asn Ser Leu Lys Tyr 
    290                 295                 300                 


Met Ala Thr His Trp Val Phe Ser Ile Leu Ala Phe Lys Gly Leu Lys 
305                 310                 315                 320 


Gln Arg Leu Thr Asn Ser Phe Glu Lys Glu Ser Leu Leu Ile Gln Met 
                325                 330                 335     


Met Asp Glu Leu Asn Lys Val Pro Asp Glu Leu Tyr Gln Thr Leu Ser 
            340                 345                 350         


Glu Thr Ala Lys Lys Glu Phe Leu Glu Asp Ile Asn Glu Tyr Val Ser 
        355                 360                 365             


Glu Gly Asp Asp Asn Glu Lys Ala Thr Tyr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Ser Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gln Phe Pro Thr Leu Lys Phe Gln Ile Phe Val Gly 
                405                 410                 415     


Gln Tyr Leu His Asp Asn Arg Pro Lys Thr Leu Ala Ser Asn Gly Met 
            420                 425                 430         


Thr Ala Gln Arg Met Ile Lys Glu Lys Ile Asn Leu Phe Gly Asn Leu 
        435                 440                 445             


Ser Glu Val Thr Lys His Lys Ser Asp Phe Phe Glu Lys Glu Ser Ala 
    450                 455                 460                 


Ala Gln Gly Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Trp Ala Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Val Tyr Ile Asp Met Ile Gly Lys Glu Gly Lys Ala 
                485                 490                 495     


Lys Glu Ile Gln Val Gln Ile Asn Lys Tyr Arg Lys Gln Leu Asn Pro 
            500                 505                 510         


Ala Pro Gln Arg Asp Lys Arg Ile Ser Lys Lys Glu Ile Ile Glu Gln 
        515                 520                 525             


Leu Tyr Lys Glu Lys Val Val Tyr Gly Asp Pro Thr Leu Met Leu Ser 
    530                 535                 540                 


Ala Asn Glu Leu Met Ala Leu Leu Tyr Glu Leu Ile Val Asn Gly Lys 
545                 550                 555                 560 


Ser Gly Ala Glu Leu Glu Asn Lys Ile Val Glu Gln Ile Ile Ala Arg 
                565                 570                 575     


Tyr Glu Gln Ile Glu Ala Tyr Asp Pro Thr Thr Gln Gln Leu Pro Thr 
            580                 585                 590         


Asn Gln Met Pro His Lys Leu Gln Lys Ser Arg Lys Asp Ser Lys Val 
        595                 600                 605             


Thr Asp Thr Asp Lys Leu Leu Lys Thr Ile Asp Lys Glu Ile Asp Glu 
    610                 615                 620                 


Gly Asn Lys Lys Leu Glu Leu Ile Ala Cys His Arg Lys Glu Trp Glu 
625                 630                 635                 640 


Glu Ala Glu Gln Arg Lys Lys Ser Gly Lys Arg Asn Asn Pro Gly Thr 
                645                 650                 655     


Lys Ser Arg Lys His Leu Phe Tyr Ala Ser Glu Met Gly Glu Glu Ala 
            660                 665                 670         


Thr Trp Ile Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Pro Ala Arg 
        675                 680                 685             


Ala Glu Trp Lys Gly Thr His His Ser Glu Leu Gln Arg Leu Leu Ala 
    690                 695                 700                 


Phe Tyr Ser Thr Gln Arg Leu Glu Ala Trp Gln Leu Val Glu Ser Val 
705                 710                 715                 720 


Trp Thr Ala Asn Thr His Ser Phe Trp Glu Glu Asn Phe Lys Glu Ala 
                725                 730                 735     


Phe Tyr Lys Pro Glu Phe Glu Asn Phe Tyr Gly Ala Tyr Ile Glu Ile 
            740                 745                 750         


Arg Thr Lys Ile Leu Thr Thr Cys Arg Ser Ile Leu Glu Asn Asn Pro 
        755                 760                 765             


Glu Ala Thr Met Asn Asn Asp Thr Glu Lys Glu Trp Asp Lys Val Phe 
    770                 775                 780                 


Thr Leu Phe Asp Lys Arg Leu Tyr Arg Thr Ser Thr Thr Asp Glu Gln 
785                 790                 795                 800 


Lys Lys Gln Leu Leu Thr Lys Pro Phe Ala Phe Pro Arg Gly Leu Phe 
                805                 810                 815     


Asp Asp Lys Pro Thr Phe Leu Pro Gly Ser Lys Pro Asn Glu Asn Pro 
            820                 825                 830         


Glu Arg Phe Ala Ala Trp Tyr Ser Tyr Gly Tyr Thr Tyr Ser Gly Lys 
        835                 840                 845             


Phe Gln Ser Phe Tyr Asp Met Pro Arg Asn Tyr Ser Asp Trp Tyr Lys 
    850                 855                 860                 


Lys Leu Lys Glu Asp Gly Lys Leu Pro Arg Leu Asp Lys Lys Thr Glu 
865                 870                 875                 880 


Gln Glu Lys Ile Leu Arg Phe Arg Met Asp Cys Asp Leu Asn Ile Lys 
                885                 890                 895     


His Ile Arg Phe Gln Asp Ile Tyr Val Lys Leu Met Val Asp Ser Leu 
            900                 905                 910         


Tyr Lys Ala Val Phe Gly Gln Gln Pro Glu Phe Asp Leu Ser His Leu 
        915                 920                 925             


Tyr Asp Thr Arg Ser Glu Arg Tyr Glu Asn Asn Thr Ile Ala Gln Arg 
    930                 935                 940                 


Gln Lys Ser Arg Gln Glu Gly Asp Asn Ser Asp Asn Ala Ile Asn Glu 
945                 950                 955                 960 


Asn Tyr Val Trp Asn Lys Thr Phe Ala Ile Ser Leu Tyr Asn Gly Arg 
                965                 970                 975     


Ile Thr Glu Ser Gln Val Lys Leu Lys Asp Val Gly Lys Phe Arg Arg 
            980                 985                 990         


Phe Ala Thr Asp Pro Arg Val Gln  Thr Leu Ile Ser Tyr  Asp Asp Thr 
        995                 1000                 1005             


Arg Thr  Trp Thr Lys Leu Glu  Ile Glu Asn Glu Leu  Asp Asn Lys 
    1010                 1015                 1020             


Ala Asp  Ala Tyr Glu Pro Ile  Arg Arg Thr Gln Ser  Leu Lys Ala 
    1025                 1030                 1035             


Ile Gln  Gln Leu Glu Lys Asn  Ile Leu Lys Lys Asn  Gly Phe Asn 
    1040                 1045                 1050             


Gly Lys  Gln His Pro Glu Glu  Leu Lys His Asn Gly  Asn Pro Asn 
    1055                 1060                 1065             


Phe Arg  Lys Tyr Ile Ala Asn  Gly Leu Leu Lys His  Arg Thr Asp 
    1070                 1075                 1080             


Ile Arg  Gln Glu Glu Leu Ala  Leu Ile Ser Asp Thr  Glu Phe Gln 
    1085                 1090                 1095             


Glu Ile  Gly Leu Glu Arg Ile  Arg Gln Thr Asn Pro  Leu Ile Gln 
    1100                 1105                 1110             


Lys Ala  Tyr Leu Leu Ile Leu  Leu Arg Asn Lys Phe  Gly His Asn 
    1115                 1120                 1125             


Gln Leu  Pro Asp Gln Glu His  Phe Arg Leu Met Arg  Ser Ile Tyr 
    1130                 1135                 1140             


Pro Tyr  Asn Gln Gln Glu Ser  Tyr Ser Ala Tyr Phe  Asn His Val 
    1145                 1150                 1155             


Ile Thr  Gln Ile Ile Glu Glu  Leu Asn Thr 
    1160                 1165             


<210>  1502
<211>  1149
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1502

Met Met Glu Lys Glu Asn Val Gln Gly Ser His Ile Tyr Tyr Glu Pro 
1               5                   10                  15      


Thr Asp Lys Cys Phe Trp Ala Ala Phe Tyr Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Leu Thr Val Ala His Ile Asn Ser Phe Val Asn Ser Lys Lys 
        35                  40                  45              


Gly Ile Asn Asn Asp Asp Lys Val Leu Asp Val Ile Asp Ala Trp Ser 
    50                  55                  60                  


Lys Phe Asp Ala Asp Leu Leu Met Gly Ala Arg Leu Asn Lys Leu Ile 
65                  70                  75                  80  


Leu Lys His Phe Pro Phe Leu Lys Ala Pro Leu Tyr Lys Gln Thr Lys 
                85                  90                  95      


Lys Glu Ala Ser Lys Gln Tyr Lys Glu Glu Asn Pro Ser Ala Asp Lys 
            100                 105                 110         


Gln Lys Ile Glu Lys Glu Ser Ala Lys Thr Ala Met Ala Asn Thr Leu 
        115                 120                 125             


Glu Leu Glu Asn Val Arg Lys Ile Leu Arg Glu Phe Leu Gln Gln Leu 
    130                 135                 140                 


Glu Asp Leu Arg Asn His Phe Ser His Tyr Asn Tyr Asn Ser Pro Asp 
145                 150                 155                 160 


Glu Lys Thr Glu Val Lys Phe Asp Asn Ser Phe Cys Asn Lys Leu Tyr 
                165                 170                 175     


Tyr Val Phe Asp Ala Ala Leu Gln Met Val Lys Asp Asp Asn Arg Met 
            180                 185                 190         


Asn Pro Glu Ile Asn Met Gln Thr Asp Phe Glu His Leu Val Arg Leu 
        195                 200                 205             


Gly Pro Asn Gly Glu Ile Ser His Ser Phe Lys Tyr Lys Phe Ile Glu 
    210                 215                 220                 


Pro Asp Gly Thr Ile Asn Asn Asn Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Lys Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Asn Tyr Met Arg Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Asn Arg Met Val Ile Pro Lys Leu Arg Leu Glu Thr Asp Tyr 
        275                 280                 285             


Asp Asn His Gln Leu Met Phe Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Leu Ser Leu Tyr Lys Arg Leu Lys Lys Glu Asp Gln Asp Lys Phe 
305                 310                 315                 320 


Gln Val Pro Ile Glu Phe Leu Asp Glu Asp Asn Glu Ala Asp Asn Gln 
                325                 330                 335     


Tyr Gln Glu Asn Ala Asn Ser Asp Glu Asn Pro Thr Glu Glu Thr Asp 
            340                 345                 350         


Pro Leu Lys Asn Thr Leu Val Arg His Gln His Arg Phe Pro Tyr Phe 
        355                 360                 365             


Val Leu Arg Tyr Phe Asp Leu Asn Glu Val Phe Lys Gln Leu Arg Phe 
    370                 375                 380                 


Gln Ile Asn Leu Gly Cys Tyr His Phe Ser Ile Tyr Asp Lys Thr Ile 
385                 390                 395                 400 


Gly Glu Arg Thr Glu Lys Arg His Leu Thr Arg Thr Leu Phe Gly Phe 
                405                 410                 415     


Asp Arg Leu Gln Asn Phe Ser Val Lys Leu Gln Pro Gln His Trp Lys 
            420                 425                 430         


Asn Met Val Lys His Leu Asp Thr Glu Glu Ser Ser Asp Lys Pro Tyr 
        435                 440                 445             


Leu Ser Asp Ala Met Pro His Tyr Gln Ile Glu Asn Glu Lys Ile Gly 
    450                 455                 460                 


Ile His Phe Leu Lys Thr Asp Thr Glu Lys Lys Glu Thr Val Trp Pro 
465                 470                 475                 480 


Ser Leu Glu Val Glu Glu Val Ser Ser Asn Arg Asn Lys Tyr Lys Ser 
                485                 490                 495     


Glu Lys Asn Leu Thr Ala Asp Ala Phe Leu Ser Thr His Glu Leu Leu 
            500                 505                 510         


Pro Met Met Phe Tyr Tyr Gln Leu Leu Ser Ser Glu Glu Lys Thr Arg 
        515                 520                 525             


Ala Ala Ala Gly Asp Lys Val Gln Gly Val Leu Gln Ser Tyr Arg Lys 
    530                 535                 540                 


Lys Ile Phe Asp Ile Tyr Asp Asp Phe Ala Asn Gly Thr Ile Asn Ser 
545                 550                 555                 560 


Met Gln Lys Leu Asp Glu Arg Leu Ala Lys Asp Asn Leu Leu Ser Gly 
                565                 570                 575     


Asn Met Pro Gln Gln Met Leu Ala Ile Leu Glu His Gln Glu Pro Asp 
            580                 585                 590         


Met Glu Gln Lys Ala Lys Glu Lys Leu Asp Leu Leu Ile Thr Glu Thr 
        595                 600                 605             


Glu Glu Arg Ile Asp Lys Leu Asn Ala Gln Phe Lys Gln Lys Val Arg 
    610                 615                 620                 


Ile Gly Lys Arg Arg Ala Gly Leu Pro Lys Val Gly Ser Ile Ala Asp 
625                 630                 635                 640 


Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Ala Lys Arg Ser Ala 
                645                 650                 655     


Asp Asn Thr Gly Val Pro Gly Ser Lys Ala Asn Ser Thr Glu Tyr Arg 
            660                 665                 670         


Leu Leu Gln Glu Ala Leu Ala Phe Tyr Ser Thr Tyr Lys Asp Arg Leu 
        675                 680                 685             


Glu Pro Tyr Phe Arg Gln Val Asn Leu Ile Gly Asp Thr Asn Pro His 
    690                 695                 700                 


Pro Phe Leu His Arg Val Asp Trp Lys Lys Cys Asn His Leu Leu Ser 
705                 710                 715                 720 


Phe Tyr His Asp Tyr Leu Glu Ala Lys Lys Arg Tyr Leu Ser Asn Leu 
                725                 730                 735     


Ser Pro Ala Asp Trp Gln Lys His Gln His Phe Leu Leu Leu Lys Val 
            740                 745                 750         


Arg Lys Asp Ile Gln Asn Glu Lys Lys Asp Trp Lys Lys Ser Leu Val 
        755                 760                 765             


Ala Gly Trp Lys Asn Gly Phe Asn Leu Pro Arg Gly Leu Phe Thr Glu 
    770                 775                 780                 


Ser Ile Lys Thr Trp Phe Ser Thr His Ala Asp Lys Val Gln Ile Thr 
785                 790                 795                 800 


Asp Thr Lys Leu Phe Glu Asn Arg Val Gly Leu Ile Ala Lys Leu Ile 
                805                 810                 815     


Pro Leu Tyr Tyr Asp Lys Val Tyr Asn Asp Lys Pro Gln Pro Phe Tyr 
            820                 825                 830         


Gln Tyr Pro Phe Asn Ile Asn Asp Arg Tyr Lys Pro Glu Asp Ala His 
        835                 840                 845             


Lys Gln Phe Thr Ala Ala Ser Ser Lys Leu Trp Asn Glu Lys Lys Met 
    850                 855                 860                 


Leu Tyr Lys Asn Ala Gln Pro Asp Ser Ser Asp Lys Ile Glu Tyr Pro 
865                 870                 875                 880 


Gln Tyr Leu Asp Phe Leu Ser Trp Lys Lys Leu Glu Arg Glu Leu Arg 
                885                 890                 895     


Met Leu Arg Asn Gln Asp Met Met Val Trp Leu Met Cys Lys Asp Leu 
            900                 905                 910         


Phe Ala Gln Cys Thr Val Glu Gly Val Glu Phe Ala Asp Leu Lys Leu 
        915                 920                 925             


Ser Gln Leu Glu Val Asp Val Thr Val Gln Asp Asn Leu Asn Val Leu 
    930                 935                 940                 


Asn Asn Val Ser Ser Met Ile Leu Pro Leu Ser Val Tyr Pro Ser Asp 
945                 950                 955                 960 


Ala Gln Gly Asn Ile Leu Arg Asn Ser Lys Pro Leu His Thr Val Tyr 
                965                 970                 975     


Val Gln Glu Lys Asn Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ser 
            980                 985                 990         


Leu Leu Lys Asp Arg Arg Leu Asn  Gly Leu Phe Ser Phe  Ile Ala Ala 
        995                 1000                 1005             


Glu Gly  Glu Asp Leu Gln Gln  His Pro Leu Thr Lys  Asn Arg Leu 
    1010                 1015                 1020             


Glu Tyr  Glu Leu Ser Ile Tyr  Gln Thr Met Arg Ile  Ser Val Phe 
    1025                 1030                 1035             


Glu Gln  Thr Leu Gln Leu Glu  Lys Ala Ile Leu Thr  Arg Asn Glu 
    1040                 1045                 1050             


Met Leu  Cys Gly Asn Asn Phe  Asn Asn Leu Leu Asn  Ser Trp Ser 
    1055                 1060                 1065             


Glu Tyr  Arg Thr Asp Lys Lys  Thr Leu Gln Pro Asp  Ile Asp Phe 
    1070                 1075                 1080             


Leu Ile  Ala Val Arg Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met 
    1085                 1090                 1095             


Ser Thr  Asn Thr Val Met Gln  Gly Ile Glu Lys Phe  Asn Ile Arg 
    1100                 1105                 1110             


Thr Ser  Arg Leu Ala Glu Lys  Asp Gly Leu Gly Ile  Ala Ser Gln 
    1115                 1120                 1125             


Leu Ala  Lys Lys Thr Lys Asp  Ala Ala Ser Arg Leu  Gln Asn Ile 
    1130                 1135                 1140             


Ile Asn  Gly Gly Thr Asn 
    1145                 


<210>  1503
<211>  1122
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1503

Met Glu Asp Asp Lys Lys Thr Thr Asp Ser Ile Ser Tyr Glu Leu Lys 
1               5                   10                  15      


Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val 
            20                  25                  30          


Tyr Ile Thr Val Asn His Ile Asn Lys Ile Leu Glu Glu Asp Glu Ile 
        35                  40                  45              


Asn Arg Asp Gly Tyr Glu Asn Thr Leu Glu Asn Ser Trp Asn Glu Ile 
    50                  55                  60                  


Lys Asp Ile Asn Lys Lys Asp Arg Leu Ser Lys Leu Ile Ile Lys His 
65                  70                  75                  80  


Phe Pro Phe Leu Glu Ala Thr Thr Tyr Arg Gln Asn Pro Thr Asp Thr 
                85                  90                  95      


Thr Lys Gln Lys Glu Glu Lys Gln Ala Glu Ala Gln Ser Leu Glu Asn 
            100                 105                 110         


Leu Lys Glu Ser Phe Phe Val Phe Ile Tyr Lys Leu Arg Asp Leu Arg 
        115                 120                 125             


Asn His Tyr Ser His Tyr Lys His Ser Lys Ser Leu Glu Arg Pro Lys 
    130                 135                 140                 


Phe Glu Glu Asp Leu Gln Lys Lys Met Tyr Asn Ile Phe Asn Ala Ser 
145                 150                 155                 160 


Ile Arg Leu Val Lys Glu Asp Tyr Gln Tyr Asn Lys Asn Ile Asn Pro 
                165                 170                 175     


Lys Lys Asp Phe Lys His Leu Asn Arg Lys Arg Lys Gly Lys Phe Tyr 
            180                 185                 190         


Tyr Ser Phe Ala Asp Asn Glu Gly Asn Ile Thr Glu Ser Gly Leu Leu 
        195                 200                 205             


Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Val Gln 
    210                 215                 220                 


Lys Lys Leu Glu Gly Phe Lys Cys Ser Asn Glu Ser Tyr Gln Lys Met 
225                 230                 235                 240 


Thr Asn Glu Val Phe Cys Arg Ser Arg Met Leu Leu Pro Lys Leu Arg 
                245                 250                 255     


Leu Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu Asn 
            260                 265                 270         


Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Arg Glu Glu 
        275                 280                 285             


Tyr Arg Glu Lys Phe Arg Val Pro Phe Glu Ile Ala Asp Glu Asp Tyr 
    290                 295                 300                 


Asp Ala Glu Gln Glu Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp 
305                 310                 315                 320 


Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Tyr Asn Glu Ile Phe 
                325                 330                 335     


Thr Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile 
            340                 345                 350         


Tyr Lys Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg His Leu Thr His 
        355                 360                 365             


Lys Leu Tyr Gly Phe Glu Arg Ile Gln Glu Phe Asp Lys Gln Asn Arg 
    370                 375                 380                 


Pro Asp Glu Trp Lys Ala Ile Ile Lys Asp Ser Asp Thr Phe Lys Lys 
385                 390                 395                 400 


Lys Glu Glu Lys Glu Glu Glu Lys Pro Tyr Ile Ser Glu Thr Thr Pro 
                405                 410                 415     


His Tyr His Leu Glu Asn Lys Lys Ile Gly Ile Ala Phe Lys Asn His 
            420                 425                 430         


Asn Ile Trp Pro Ser Thr Gln Thr Glu Leu Thr Asn Asn Lys Arg Lys 
        435                 440                 445             


Lys Tyr Asn Leu Gly Thr Ser Ile Lys Ala Glu Ala Phe Leu Ser Val 
    450                 455                 460                 


His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Lys Thr Glu 
465                 470                 475                 480 


Asn Thr Lys Asn Asp Asn Lys Val Glu Gly Lys Lys Glu Thr Lys Lys 
                485                 490                 495     


Gln Glu Lys His Lys Ile Glu Ala Ile Ile Glu Ser Lys Ile Lys Asp 
            500                 505                 510         


Met Tyr Ala Leu Tyr Asp Ala Phe Ala Asn Gly Glu Ile Asn Ser Glu 
        515                 520                 525             


Asp Glu Leu Lys Glu Tyr Leu Lys Gly Lys Asp Ile Glu Ile Val His 
    530                 535                 540                 


Leu Pro Lys Gln Met Ile Ala Ile Leu Lys Asn Glu His Lys Asp Met 
545                 550                 555                 560 


Ala Glu Lys Ala Glu Ala Lys Gln Glu Lys Met Lys Leu Ala Thr Glu 
                565                 570                 575     


Asn Arg Leu Lys Thr Leu Asp Lys Gln Leu Lys Gly Lys Ile Gln Asn 
            580                 585                 590         


Gly Lys Arg Tyr Asn Ser Ala Pro Lys Ser Gly Glu Ile Ala Ser Trp 
        595                 600                 605             


Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln Arg Asp Glu Asn 
    610                 615                 620                 


Gly Glu Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln Leu 
625                 630                 635                 640 


Leu Gln Arg Thr Leu Ala Phe Phe Gly Ser Glu His Glu Arg Leu Ala 
                645                 650                 655     


Pro Tyr Phe Lys Gln Thr Lys Leu Ile Glu Ser Ser Asn Pro His Pro 
            660                 665                 670         


Phe Leu Asn Asp Thr Glu Trp Glu Lys Cys Asn Asn Ile Leu Ser Phe 
        675                 680                 685             


Tyr Arg Ser Tyr Leu Lys Ala Arg Lys Asn Phe Leu Glu Ser Leu Lys 
    690                 695                 700                 


Pro Glu Asp Trp Glu Lys Asn Gln Tyr Phe Leu Met Leu Lys Gly Pro 
705                 710                 715                 720 


Lys Thr Asn Arg Lys Thr Leu Val Gln Gly Trp Lys Asn Gly Phe Asn 
                725                 730                 735     


Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg Lys Trp Phe Met Glu 
            740                 745                 750         


His Trp Lys Asn Ile Lys Val Asp Lys Ser Lys Arg Val Gly Leu Val 
        755                 760                 765             


Ala Lys Val Ile Pro Leu Phe Phe Ser Glu Lys Tyr Lys Asp Ser Val 
    770                 775                 780                 


Gln Pro Phe Tyr Asn Tyr Pro Phe Asn Val Gly Asp Val Asn Lys Pro 
785                 790                 795                 800 


Lys Glu Glu Asp Phe Leu His Arg Glu Glu Arg Ile Lys Ile Trp Lys 
                805                 810                 815     


Glu Lys Lys Asn Lys Phe Lys Gly Tyr Lys Ala Lys Lys Lys Phe Lys 
            820                 825                 830         


Glu Met Thr Asp Lys Glu Lys Glu Glu His Arg Ser Tyr Leu Glu Phe 
        835                 840                 845             


Gln Ser Trp Asn Lys Phe Glu Arg Glu Leu Arg Leu Val Arg Asn Gln 
    850                 855                 860                 


Asp Ile Val Thr Trp Leu Leu Cys Thr Glu Leu Ile Asp Lys Leu Lys 
865                 870                 875                 880 


Ile Asp Glu Leu Asn Ile Lys Glu Leu Lys Lys Leu Arg Leu Lys Asp 
                885                 890                 895     


Ile Asn Thr Asp Thr Ala Lys Lys Glu Lys Asn Asn Ile Leu Asn Arg 
            900                 905                 910         


Val Met Pro Met Glu Leu Pro Val Thr Val Tyr Glu Val Asn Lys Gly 
        915                 920                 925             


Gly Tyr Ile Ile Lys Asn Lys Pro Leu His Thr Ile Tyr Ile Lys Glu 
    930                 935                 940                 


Ala Lys Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys 
945                 950                 955                 960 


Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Val Lys Thr Pro Ser Glu 
                965                 970                 975     


Ala Glu Ser Glu Ser Asn Pro Ile Ser Lys Ser Arg Val Glu Ser Glu 
            980                 985                 990         


Leu Gly Lys Tyr Gln Asn Ala Arg  Leu Asp Ile Ile Glu  Asp Met Leu 
        995                 1000                 1005             


Ala Leu  Glu Lys Thr Leu Ile  Asp Asn Tyr Asn Ser  Leu Asp Thr 
    1010                 1015                 1020             


Asp Asn  Phe His Asn Met Leu  Thr Ala Trp Leu Glu  Leu Lys Gly 
    1025                 1030                 1035             


Glu Ala  Asn Lys Ala Arg Phe  Gln Asn Asp Val Asp  Leu Leu Val 
    1040                 1045                 1050             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asn 
    1055                 1060                 1065             


Glu Asn  Leu Phe Gly Asn Ile  Glu Arg Phe Ser Leu  Ser Ser Ser 
    1070                 1075                 1080             


Asn Ile  Ile Glu Ser Lys Gly  Leu Asp Ile Ala Ala  Lys Leu Lys 
    1085                 1090                 1095             


Glu Glu  Val Ser Lys Ala Ala  Lys Lys Ile Gln Asn  Glu Glu Asp 
    1100                 1105                 1110             


Asn Lys  Lys Glu Lys Glu Lys  Glu Thr 
    1115                 1120         


<210>  1504
<211>  1141
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1504

Met Ala Gln Thr Arg Trp Lys Gln Ser Lys Thr Pro Ala Ile Lys Pro 
1               5                   10                  15      


Val Met Ala Ala Tyr Leu Asn Met Ala Arg His Asn Met Tyr Arg Val 
            20                  25                  30          


Met Leu His Ile Ser Arg Gln Met Gln Ile Val Glu Asn Lys Glu Glu 
        35                  40                  45              


Ala Glu Ile Ala Ala Phe Ser Val Trp Gln Lys Leu Ser Ser Gly Thr 
    50                  55                  60                  


Pro Thr Glu Gln Met Lys Met Ile Lys Leu Leu Gln Arg His Phe Pro 
65                  70                  75                  80  


Val Leu Lys Pro Val Phe Asp Val Glu Lys Lys Lys Asn Val Glu Asn 
                85                  90                  95      


Ala Ala Ile Ser Ala Ser Pro Lys Glu Ile Lys Arg Ile Phe Thr Thr 
            100                 105                 110         


Ile Leu Thr Ala Leu Asn Arg Leu Arg Asn Glu Tyr Ser His Tyr Ser 
        115                 120                 125             


Pro Val Pro Arg Lys Thr Glu Gly Glu Glu Lys Met Ile Ala Tyr Leu 
    130                 135                 140                 


Tyr Arg Cys Met Asp Gly Ser Ala Arg Glu Val Arg Asn Arg Phe Ser 
145                 150                 155                 160 


Leu Thr Val Lys Asp Pro Lys Gly Ala Lys Glu Thr Ala Lys Val Leu 
                165                 170                 175     


Glu Val Asn Lys Ala Val Phe Asp Ile Phe Gln Asp Ala Phe Arg Lys 
            180                 185                 190         


Glu Lys Val Lys Ala Leu Asp Lys Ser Gly Lys Val Ile Lys Asp Asn 
        195                 200                 205             


Lys Gly Arg Thr Gln Phe Glu Phe Arg Asp Lys Glu Asp Tyr Tyr Tyr 
    210                 215                 220                 


Ala Leu Lys Asp Ala Asn Ala Ala Leu Ser Asp Met Gly Ile Val Phe 
225                 230                 235                 240 


Phe Thr Cys Leu Phe Leu Glu Lys Arg Tyr Ala Ala Met Phe Leu Asp 
                245                 250                 255     


Ala Ile Lys Pro Trp Pro Gln Asp Phe Asn Glu Ile Glu Arg Lys Ala 
            260                 265                 270         


Val Leu Glu Val Phe Thr Val Tyr His Ile His Leu Pro Lys Glu Lys 
        275                 280                 285             


Tyr Asp Ser Thr Arg Pro Glu Tyr Ala Leu Gly Leu Asp Met Leu Asn 
    290                 295                 300                 


Glu Leu Gln Lys Cys Pro Lys Glu Leu Phe Asp Ile Leu Ser Ala Lys 
305                 310                 315                 320 


Ser Arg Asp Ala Leu Ser Val Asp Ile Lys Ala Asp Arg Pro Asp Val 
                325                 330                 335     


Val Thr Asp Asp Gly Val Thr Val Lys Asp Gly Lys Val Gln Met Arg 
            340                 345                 350         


Arg Val Arg Asp Arg Phe Ala Pro Leu Ala Leu Gln Tyr Leu Asp Ser 
        355                 360                 365             


Gln Lys Ala Phe Asn Asp Ile Arg Phe Met Val Arg Leu Gly His Tyr 
    370                 375                 380                 


Arg Phe Lys Phe Tyr Lys Lys Gln Cys Val Ala Asp Asn Ala Pro Asp 
385                 390                 395                 400 


Thr Leu Arg Val Leu Gln Lys Glu Ile Asn Gly Phe Gly Arg Leu Asp 
                405                 410                 415     


Glu Met Glu Ala Ala Arg Lys Lys Asn Tyr Thr Pro Leu Phe Lys Ala 
            420                 425                 430         


Thr Cys Val Lys Thr Asn Asp Lys Gly Ile Glu Val His Glu Leu Val 
        435                 440                 445             


Pro Asp Ala Pro Asp Ser Ala Pro Tyr Ile Thr Asp Thr Lys Ala His 
    450                 455                 460                 


Tyr Leu Ile Asp Asn Asn Arg Val Gly Leu Arg Ile Asp Asn Pro Ser 
465                 470                 475                 480 


Phe Leu Pro Ser Leu Arg Gly Glu Lys Gly Ala Pro Ile Gln Ser Ala 
                485                 490                 495     


Gly Asp Ile Ser Leu Leu Ser Pro Gln Ala Trp Leu Ser Thr Tyr Glu 
            500                 505                 510         


Leu Pro Gly Leu Val Phe Tyr Gln Tyr Leu Tyr Asp Thr Tyr Asp Gly 
        515                 520                 525             


His Gly Lys His Leu Pro Ser Ala Glu Glu Ile Ile Lys Ser Tyr Ile 
    530                 535                 540                 


Leu Ala Tyr Lys Arg Leu Phe Val Asp Leu Gly Glu Gly Ser Phe Asp 
545                 550                 555                 560 


Gly Trp Asp Glu Tyr Ala Tyr Ala Pro Leu Thr Leu Gly Asp Leu Pro 
                565                 570                 575     


Gln Lys Ile Lys Gly Phe Ile Leu His Pro Ser Ala Thr Ile Asp Pro 
            580                 585                 590         


Arg Phe Gln Asp Lys Ala Asn Asn Arg Ile Asp Asp Met Ile Lys Arg 
        595                 600                 605             


Thr Glu Ala Glu Ile Ala Gly Phe Tyr Thr Lys Met Lys Lys Leu Ser 
    610                 615                 620                 


Asp Lys Ser Asn Lys Leu Gly Lys Lys Lys Tyr Val Asp Leu Gln Pro 
625                 630                 635                 640 


Gly Ser Ile Ala Ser Arg Leu Val Arg Asp Ile Leu Phe Phe Thr Pro 
                645                 650                 655     


Val Ser Glu Glu Lys Ala Lys Ile Thr Ser Ala Asn Phe Asn Ser Leu 
            660                 665                 670         


Gln Ser Ala Leu Ala Leu Ser Glu Leu Gly Thr Asn Arg Ile Lys Asp 
        675                 680                 685             


Ile Leu Arg Gly Leu Asn His Pro Phe Val Met Glu Ala Phe Glu Asn 
    690                 695                 700                 


Tyr Arg Val Glu Asp Phe His Leu Phe Asp Phe Trp Lys Val Tyr Leu 
705                 710                 715                 720 


Asn Lys Arg Leu Asp Tyr Leu Lys Gly Leu Asp Arg Glu Lys Leu Glu 
                725                 730                 735     


Glu Val Pro Phe Leu His Ser Ser Arg Thr Arg Trp Gln Lys Arg Asp 
            740                 745                 750         


Glu Lys Tyr Ile Lys Leu Leu Ala Gly Arg Tyr Glu Gln Phe Glu Leu 
        755                 760                 765             


Pro Arg Ser Leu Phe Thr Ala Pro Thr Arg Val Leu Leu Asp Glu Val 
    770                 775                 780                 


Ala Leu His Phe Glu Ser Gly Ser Asp Arg Asp Leu Ser Met Gly Asn 
785                 790                 795                 800 


Leu Ile Asn Leu Phe Phe Ser Lys Val Leu Ser Asp Asn Asn Gln Pro 
                805                 810                 815     


Phe Tyr Arg Trp Glu Arg His Tyr Asp Val Phe Asp Lys Leu Ala Gly 
            820                 825                 830         


Val Lys Ser Gly Ile Ser Leu Val His Gln Phe Phe Lys Pro Glu Gln 
        835                 840                 845             


Leu Ala Lys Lys Met Arg Glu Arg Lys Thr Leu Lys Pro Ser Leu Tyr 
    850                 855                 860                 


Met Cys Glu Lys Ala Val Asn Ser Val Asn Gln Asn Leu Lys Lys Gly 
865                 870                 875                 880 


Glu Arg Arg Leu Asn Ile His Ser Ser Thr Asp Leu Lys Asp Phe Arg 
                885                 890                 895     


Val Ile Ala Val Ala Lys Glu Asn Leu Lys Lys Ala Tyr Gln Asp Tyr 
            900                 905                 910         


Asp Asp Asn Glu Arg Ile Leu Arg Arg Phe Ala Ile Gln Asp Lys Val 
        915                 920                 925             


Met Tyr Leu Met Ala Lys Ser Ile Leu Leu Gly Ile Glu Gly Ile Glu 
    930                 935                 940                 


Met Gly Ser Leu Asp Arg Phe Lys Leu Lys Asp Ile Leu Pro Gly Lys 
945                 950                 955                 960 


Asn Asn Thr Ile Leu Asp Ile Leu Val Pro Phe Ser Ile Val Leu Glu 
                965                 970                 975     


Ile Asp Gly Ile Lys Val Leu Ile Arg Gln Lys Glu Lys Val Lys Ile 
            980                 985                 990         


Lys Arg Tyr Gly Glu Phe Phe Arg  Tyr Asn Thr Asp Thr  Arg Leu Arg 
        995                 1000                 1005             


Ser Leu  Leu Pro Leu Leu Gly  Lys Thr Leu Gly Ala  Asp Ala Glu 
    1010                 1015                 1020             


Ile Asn  Val Glu Leu Asp Arg  Glu Thr Leu Glu Glu  Glu Leu Phe 
    1025                 1030                 1035             


Ala Tyr  Asp Arg Glu Arg Val  Val Val Met Arg Met  Val Leu Ser 
    1040                 1045                 1050             


Leu Glu  Gln Ser Ile Leu Ser  Arg Ser Thr Gly Asp  Val Pro Glu 
    1055                 1060                 1065             


Met Asp  Arg Glu Asn Phe Asn  Asn Leu Val Ser Lys  Val Gly His 
    1070                 1075                 1080             


Ile Pro  Tyr Lys Ser His Gly  Gln Ile Leu Ile Asn  Ile Arg Asn 
    1085                 1090                 1095             


Ser Phe  Cys His Asn Glu Tyr  Ala Arg Asp Ile Val  Leu Pro Glu 
    1100                 1105                 1110             


Gly Thr  Pro Leu Pro Gln Val  Ala Glu Thr Ile Ser  Lys Leu Phe 
    1115                 1120                 1125             


Glu Thr  Glu Arg Lys Arg Arg  Pro Asn Gln Cys Gln  Glu 
    1130                 1135                 1140     


<210>  1505
<211>  1254
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1505

Met Gly Asn Tyr Gln Gln Asn Trp Lys Lys Arg Arg Thr Gly Ser Gln 
1               5                   10                  15      


Pro Asn Ala Met Ser Asp Gln Leu Arg Pro Val Phe Ala Ala Tyr Leu 
            20                  25                  30          


Asn Met Ala Arg Ala Asn Leu Tyr Ser Val Leu Arg Tyr Ile Ser Val 
        35                  40                  45              


Gln Cys Gly Leu Glu Val Asn Gln Asn Glu Asp Ser Met His Glu Leu 
    50                  55                  60                  


Pro Ile Ala Lys Phe Ala Ser Asn Lys Arg Pro Glu Val Arg Gln Lys 
65                  70                  75                  80  


Ala Phe Leu Leu Leu Met Arg Asn Ile Pro Ile Leu Gln Gln Met Thr 
                85                  90                  95      


Gln Ser Gly Leu Thr Gln Gly Lys Pro Ala Asp Gly Asp Arg Pro Ala 
            100                 105                 110         


Lys Glu Lys His Leu Ala Val Glu Gln Glu Asp Leu Gln Arg Val Leu 
        115                 120                 125             


Gln Asn Leu Ile Arg Val Val Asn Phe Lys Arg Asn Leu Phe Thr His 
    130                 135                 140                 


Ala Asp His Tyr Asp Thr Asp Glu Glu Ile Glu Lys Glu Leu Gln Arg 
145                 150                 155                 160 


Glu Val Ala Leu Ser Gly Pro Leu Asn Thr Ala Phe Lys Gly Ser Lys 
                165                 170                 175     


Arg Glu Val Lys Arg Ile Phe Cys Tyr Thr Glu Lys Asp Met Asn Phe 
            180                 185                 190         


Val Asp Gln Asp Glu His Met Lys Arg Ile Pro Met Lys Asp Lys Asn 
        195                 200                 205             


Gly Asn Ile Met Gln Asp Glu Lys Gly Lys Asp Met Tyr Ile Phe Val 
    210                 215                 220                 


Glu Arg Ser Asn Trp Tyr Phe Arg Leu Tyr Asp Thr Thr Pro Asp Pro 
225                 230                 235                 240 


Val Thr Glu Met Pro Leu Ala Gln Lys Leu Thr Thr Val Gly Leu Val 
                245                 250                 255     


Phe Ile Leu Cys Lys Leu Leu His Lys Lys Tyr Ala Thr Gln Leu Val 
            260                 265                 270         


Gln Lys Thr Gly Leu Phe Arg Thr Arg Ala Gln Ser Gly Asn Ser Pro 
        275                 280                 285             


Phe Glu Lys Asn Glu Asn Glu Val Met Phe Asn Ile Phe Cys Ala His 
    290                 295                 300                 


Arg Ile Arg Leu Pro Lys Gly Arg Val Glu Ser Thr Val Ser Asn Tyr 
305                 310                 315                 320 


Ala Leu Gly Leu Asp Ile Leu Asn Glu Leu Gln Lys Cys Pro Ser Glu 
                325                 330                 335     


Leu Phe Glu Thr Leu Ser Pro Glu Asp Lys Glu Cys Phe Gln Val Lys 
            340                 345                 350         


Arg Lys Asp Asn Glu Thr Gln Pro Asp Pro Asp Asp Asp Val Asn Leu 
        355                 360                 365             


Phe Arg Arg Tyr Gly Asp Arg Phe Pro Tyr Leu Ala Met Arg Tyr Ile 
    370                 375                 380                 


Asp Ala Met Arg Gly Tyr Gln Asp Asp Tyr Lys Val Leu Glu Asp Ile 
385                 390                 395                 400 


Val Phe Gln Val Ser Leu Gly Lys Tyr Arg Phe Ser Phe Tyr Asn Arg 
                405                 410                 415     


Ala Ser Leu Asp Thr Thr Glu Lys Asp Arg Val Arg Val Leu Gln Lys 
            420                 425                 430         


Glu Ile Asn Gly Phe Gly Pro Ile Asp Lys Met Glu Gln Lys Arg Lys 
        435                 440                 445             


Glu Lys Tyr Lys Thr Ile Ile Arg Pro Ile Ser Asp Asp Pro Lys His 
    450                 455                 460                 


Leu Tyr Asp Ala Asp Thr Ala Glu Thr Gln Pro Tyr Leu Thr Asp Gln 
465                 470                 475                 480 


His Thr Ala Tyr Ala Ile Thr Gly Asn Arg Ile Gly Ile Thr Trp Asn 
                485                 490                 495     


Glu Arg Ile Gln Lys Pro Gln Ser Asn Glu Met Arg Ser Ser Ile Arg 
            500                 505                 510         


Leu Arg Trp Pro Glu Asn Glu Gln Asn Lys Val Ile Asn Ile Glu Lys 
        515                 520                 525             


Leu Asp Asn Asp Asn Cys Phe Leu Pro Asn Leu Pro Val Ser Thr Val 
    530                 535                 540                 


Asn Ile Ala Pro Arg Ala Trp Leu Ser Val His Asp Leu Pro Ala Leu 
545                 550                 555                 560 


Ile Phe Leu Arg Leu Leu Gly Gly Asp Pro Glu Ala Val Ile Lys Asp 
                565                 570                 575     


Thr Tyr Asn Arg Phe Val Leu Leu Leu Asn Ser Ile Lys Asn Gly Gln 
            580                 585                 590         


Leu Lys Pro Gln Asp Asn Lys Glu Lys Leu Leu Ala Ile Leu Ser Ala 
        595                 600                 605             


Glu Pro Tyr Lys Leu Arg Leu Ser Glu Ile Pro Lys Lys Leu Leu Asp 
    610                 615                 620                 


Tyr Leu Ser Ser Lys Gly Pro Lys Thr Gln Asp Glu Ala Asn Gln Ala 
625                 630                 635                 640 


Phe Thr Lys Trp Val Asn Lys Gln Leu Asp Gly Asp Val Gly Ile Ile 
                645                 650                 655     


Glu Lys Leu Arg Ile Arg Ile Glu Gln Phe Lys Gln Asp Leu Asn Val 
            660                 665                 670         


Val Gly Asp Lys Gln Asn Arg Ile Gly Arg Lys Gly Tyr Val Asp Ile 
        675                 680                 685             


Arg Pro Gly Ser Leu Ala Arg Tyr Ile Thr Lys Asp Ile Met Ala Met 
    690                 695                 700                 


Thr Arg Pro Asp Glu Ser Arg Lys Asn Asn Gly Lys Pro Ser Gly Leu 
705                 710                 715                 720 


Asp Phe Gly Val Leu Gln Ala Ala Ile Ala Thr Phe Lys Ala Asp Glu 
                725                 730                 735     


Ile Ala Leu Ala Lys Thr Ser Leu Gly Gly Met Ile Lys Ser Ala Ile 
            740                 745                 750         


Asn Val Asn Asn His Pro Phe Leu Asn Ser Val Leu Ser Gln Gln Val 
        755                 760                 765             


Thr Asp Thr Ile Asp Leu Tyr Ile Lys Tyr Gln Thr Ala Lys Leu Lys 
    770                 775                 780                 


Phe Phe Lys Ser Leu Arg Lys Gly Glu Lys Gly Asn Tyr Lys Asp Gln 
785                 790                 795                 800 


Trp Phe Leu Arg Glu Ala Tyr Arg Asn His Ala Ala Gln Thr Ser Glu 
                805                 810                 815     


Tyr Met Gln Gly Glu Lys Gly Leu Ala Ser Leu Tyr Leu Glu Thr Leu 
            820                 825                 830         


Gln Leu Pro Asp Gly Leu Phe Thr Asp Ala Ile His Lys Gln Leu Leu 
        835                 840                 845             


Asn Asn Glu Lys Thr Lys Asp Asn Val Glu Phe Leu Ala Ala Leu Ala 
    850                 855                 860                 


Asp Arg Glu Lys Thr Gly Gly Val Ser His Leu Ile Asn Leu Tyr Phe 
865                 870                 875                 880 


Glu Lys Val Ile Gly Asp Lys Pro Gln Ser Phe Tyr Arg Glu Met Lys 
                885                 890                 895     


Arg His Tyr Lys Val Ile Asp Trp Glu Met Phe Lys Tyr Asp Asp Glu 
            900                 905                 910         


His Pro Ile Leu Leu Thr Thr Ile Pro Pro Met Ile Tyr Ser Ser Pro 
        915                 920                 925             


Glu Lys Ile Ala Thr Leu Leu Arg Lys Gly Asp Ala Lys Glu Ser Pro 
    930                 935                 940                 


Ile Val Gln Asp Ile Asp Gln Ile Ser Asp Asn Ile Lys Arg Lys Ile 
945                 950                 955                 960 


Ser Lys Lys Trp Glu Ser Lys Pro Arg Tyr Ala Pro Ile Ser Arg Glu 
                965                 970                 975     


Glu Lys Leu Glu Leu Lys Ala Lys Leu Ile His Gln Met Arg Lys Leu 
            980                 985                 990         


Gln Gln Asn Glu Arg Asn Ile Arg  Arg Tyr Arg Asn Gln  Asp Met Leu 
        995                 1000                 1005             


Leu Phe  Glu Met Ala Lys Lys  Ile Leu Leu Ser Gly  Gly Ala Val 
    1010                 1015                 1020             


Ile Lys  Thr Asn Gly Gln Leu  Glu Arg Gly Ile Asp  Gln Phe Lys 
    1025                 1030                 1035             


Leu Gln  Asp Ile Leu Pro Pro  Ala Met Arg Gln Gly  Ser Asp Lys 
    1040                 1045                 1050             


Asp Leu  Leu Glu Gln Lys Val  Glu Phe Arg Leu Thr  Ile Asn Leu 
    1055                 1060                 1065             


Asn Asp  Glu Tyr Gly Lys Pro  Ile Lys Gly Ser Asp  Asp Lys Pro 
    1070                 1075                 1080             


Met Gln  Arg Thr Ile Ser Gln  Pro Glu Ile Lys Ile  Lys Asn Tyr 
    1085                 1090                 1095             


Gly Asp  Phe Tyr Thr Phe Leu  Tyr Asp Ser Arg Ile  Gly Thr Leu 
    1100                 1105                 1110             


Leu Ser  Gln Leu Thr Glu Asn  Gly Asp Ile Lys Arg  Asp Asp Leu 
    1115                 1120                 1125             


Glu Thr  Glu Phe Asp His Tyr  Asp Arg Gln Arg Gln  Glu Val Phe 
    1130                 1135                 1140             


Arg Leu  Leu Gln Lys Ile Glu  Arg Gln Ile Ile Lys  Ser His Pro 
    1145                 1150                 1155             


Ala Leu  Ala Asn Ser Asn Ala  Gly Lys Pro Gly Ser  Glu Phe Tyr 
    1160                 1165                 1170             


Asp Glu  Asn Gly Lys Pro Tyr  Arg Asn Ser Phe Ser  Ser Leu Leu 
    1175                 1180                 1185             


Leu Leu  Cys Lys Gln Tyr Leu  Ser Glu Gly Gly Glu  Pro Thr Asp 
    1190                 1195                 1200             


Val Ser  Asn Leu Leu Thr Glu  Ile Arg Asn Ala Phe  Ser His Asn 
    1205                 1210                 1215             


Arg Tyr  Val Lys Ser Gln Asp  Lys Gln Leu Asp Ile  Arg Thr Leu 
    1220                 1225                 1230             


Ser Leu  Pro Glu Val Ala Asp  His Ile Leu Asn Trp  Leu Arg Asn 
    1235                 1240                 1245             


His Gln  Tyr Lys Asn Glu 
    1250                 


<210>  1506
<211>  1081
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1506

Met Gln Ala Gln Ser Leu Phe Asp Glu Tyr Lys His Leu Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Val Met Ser Ile Met Asn Ile Ile Thr Val Leu Asn His Ile 
            20                  25                  30          


His Gln Ile Ala Gly Leu Lys Arg Asn Glu Leu Gly Asp Asp Asp Asn 
        35                  40                  45              


Ile Tyr Ser His Pro Val Leu Lys Tyr Ile Ala Pro Glu Asn Asn Ser 
    50                  55                  60                  


Thr Thr Leu Pro Glu Lys Arg Asp Leu Ile Lys Glu Leu Leu Leu Glu 
65                  70                  75                  80  


Tyr Leu Pro Phe Leu Glu Ala Met Lys Asp Cys Tyr Lys Glu Val Lys 
                85                  90                  95      


Val Glu Lys Asp Lys Arg Asn Asn Lys Tyr Val Lys Asp Lys Lys Gln 
            100                 105                 110         


Val Phe Ile Arg Asn Tyr Ser Asp Ile Tyr Cys Ile Tyr Trp Thr Leu 
        115                 120                 125             


Tyr Asn Ile Phe Ser Thr Leu Ile Asn Tyr Arg Asp Lys Ser Cys His 
    130                 135                 140                 


Tyr Arg Phe Ile Pro Ser Lys Asp Gln Glu Glu Tyr Ser Lys Arg Thr 
145                 150                 155                 160 


Glu Tyr Asp Thr Val Arg Ile Ile Asn Lys Tyr Tyr Thr Tyr Ala Leu 
                165                 170                 175     


Arg Lys Thr Lys Glu Lys Tyr Gly Tyr Thr Thr Glu Gln Leu Ser Phe 
            180                 185                 190         


Ile Gln Asn Asn Arg Tyr Thr Asp Asp Lys Lys Val Asn Phe Asn Phe 
        195                 200                 205             


Phe Leu Ser Met Gln Ser Ser Asn Asn Asn Leu Ser His Val Gly Val 
    210                 215                 220                 


Ala Gln Leu Ile Cys Leu Phe Leu Gln Lys Lys Asp Val Asp Asn Phe 
225                 230                 235                 240 


Leu Glu Asn Leu Pro Ile Tyr Asp Asn Arg Tyr Cys Leu Gly Ile Asp 
                245                 250                 255     


Glu His Met Ile Ile Lys Arg Ser Leu Ala Leu His Ser Ile Lys Leu 
            260                 265                 270         


Pro Lys Glu Arg Leu Asn Ser Glu Lys Lys Asp Met Ala Ile Ala Met 
        275                 280                 285             


Asp Met Leu Asn Glu Leu Lys Arg Cys Pro Lys Glu Leu Phe Asn Thr 
    290                 295                 300                 


Leu Pro Phe Asp Lys Gln Glu Arg Phe Arg Ile Ile Ser Ser Asp His 
305                 310                 315                 320 


Lys Glu Val Leu Leu Met Arg Ser Thr Asp Arg Phe Val Pro Leu Ile 
                325                 330                 335     


Leu Gln Tyr Ile Asp Cys Asn Lys Lys Phe Lys Asp Ile Arg Phe His 
            340                 345                 350         


Val Asn Met Gly Lys Leu Arg Tyr Leu Phe Ser Pro Asn Lys Leu Cys 
        355                 360                 365             


Ile Asp Asn Gln Glu Arg Val Arg Met Leu Glu His Leu Leu Asn Gly 
    370                 375                 380                 


Tyr Gly Arg Ile Asp Glu Val Glu Tyr Leu Arg Lys Ala Pro Asn Gly 
385                 390                 395                 400 


Thr Phe Gly Asn Thr Asn Ile Pro Ile Lys Gly Phe Gly Glu Ile Glu 
                405                 410                 415     


Arg Asp Ser Ala Asp Ser Asn Asn Tyr Pro Tyr Ile Val Asp Thr His 
            420                 425                 430         


Thr His Tyr Ile Leu Asn Asn Asn Lys Val Glu Phe Cys Phe Cys Glu 
        435                 440                 445             


Asp Ser Lys Asn Lys Asn Val Phe Pro Thr Ile Glu Lys Glu Ile Asn 
    450                 455                 460                 


Gly Lys Trp Tyr Val Glu Lys Thr Ala Pro His Cys Arg Ile Ser Phe 
465                 470                 475                 480 


Phe Glu Ile Pro Ala Met Ala Phe His Met Phe Leu Cys Gly Ser Glu 
                485                 490                 495     


Lys Thr Glu Lys Leu Ile Lys Asp Val Tyr Asn Asn Tyr Ile Ser Leu 
            500                 505                 510         


Phe Asn Ala Leu Lys Asn Gly Ala Leu Thr Glu Glu Asn Tyr Lys Asp 
        515                 520                 525             


Phe Asn Ile Pro Glu Cys Asp Met Pro Lys Lys Ile Leu Asp Phe Leu 
    530                 535                 540                 


Lys Gly Lys Ala Glu Gly Lys Ser Ile Asp Gly Tyr Val Lys Asn Ile 
545                 550                 555                 560 


Leu Lys Lys Glu Leu Lys Asp Thr Arg Lys Arg Ile Glu Gln Ala Pro 
                565                 570                 575     


Ser Glu Lys Asp Gln Met Pro Ser Lys Arg Asn Lys Ile Gly Thr Lys 
            580                 585                 590         


Ser Tyr Lys Arg Val Leu Thr Gly Lys Leu Ala Asp Phe Leu Ala Lys 
        595                 600                 605             


Asp Ile Val Lys Tyr Gln Pro Thr Leu Cys Ala Gly Asp Asp Tyr Gly 
    610                 615                 620                 


Ile Asp Arg Met Thr Gly Met Asn Tyr Arg Ile Met Gln Ala Thr Ile 
625                 630                 635                 640 


Ala Thr Tyr Asn Asp Asp Asp Asp Phe Asp Thr Phe Tyr Asn Val Phe 
                645                 650                 655     


Lys Met Ala Gly Leu Val Asp Gly Asp Glu Arg Lys Asn His Pro Phe 
            660                 665                 670         


Leu Lys Lys Val Leu Leu Ser Lys Pro Gln Asn Thr Val Ala Phe Asn 
        675                 680                 685             


Ile Lys Tyr Leu Lys Glu Lys Glu Ile Tyr Leu Arg Asn Ile Glu Lys 
    690                 695                 700                 


Lys Asn Ile Ile Pro Pro Phe Val Asn Arg Glu Arg Asn Lys Trp Cys 
705                 710                 715                 720 


Glu Arg Asp Cys Glu Tyr Tyr Arg Ile Leu Gly Glu Asn Leu Leu Asp 
                725                 730                 735     


Leu Pro Ile Glu Leu Pro Arg Gln Met Phe Tyr Lys Asp Ile Arg Ala 
            740                 745                 750         


Gln Leu Glu Pro Leu Met Pro Glu Ile Asp Phe Ser Gln Thr Asn Thr 
        755                 760                 765             


Thr Tyr Leu Ile Ala Glu Tyr Leu Lys Arg Val Arg Gly Asp Asp Phe 
    770                 775                 780                 


Gln Glu Phe Tyr Ser Trp Glu Arg Asn Tyr Arg Tyr Ile Asp Phe Leu 
785                 790                 795                 800 


Lys Cys Ile Arg Asp Asp Asn Gly Arg Ile Cys Ala Gln Tyr Thr Thr 
                805                 810                 815     


Thr Glu Glu Arg Glu Ser Leu Trp Glu Asp Ser Lys Asn Arg Thr Ala 
            820                 825                 830         


Glu Tyr Lys Arg Ser Glu Glu Gln Lys Asn Glu Lys Lys Asp Lys Asn 
        835                 840                 845             


Phe Glu Asp Ser Leu Glu Glu Arg Ile Ser Ser Ser His Ile Lys Phe 
    850                 855                 860                 


Gln Asn Thr Glu Lys His Ile Arg Arg Tyr Lys Val Gln Asp Ala Leu 
865                 870                 875                 880 


Leu Phe Met Ile Ala Glu Lys Gln Phe Gly Lys Tyr Leu Asp Asp Ile 
                885                 890                 895     


Lys Ala Lys Asn Phe Lys Leu Lys Asp Ile Met Pro Asp Thr Asp Lys 
            900                 905                 910         


Gly Ile Leu Ser Glu Thr Met Pro Ile Asp Phe Thr Phe Thr Lys Lys 
        915                 920                 925             


Asn Ile Lys Tyr Asn Ile His Ala Lys Asn Leu Lys Phe Lys Glu Tyr 
    930                 935                 940                 


Gly Asp Leu Phe Ile Leu Ala Asn Asp Lys Arg Leu Glu Ser Leu Trp 
945                 950                 955                 960 


Lys Ile Leu Ala Thr Asp Thr Val Asn Lys Glu Glu Ile Ser Glu Glu 
                965                 970                 975     


Phe Ala Lys Tyr Asp Phe Cys Arg Pro Asp Ile Thr Lys Leu Val Leu 
            980                 985                 990         


Asp Phe Glu Lys Asp Val Leu Glu  Lys Tyr Pro Glu Ile  Ile Glu Glu 
        995                 1000                 1005             


Ala Glu  Lys Glu Tyr Lys Lys  Phe Asp Phe Lys Phe  Ile Leu Asp 
    1010                 1015                 1020             


Trp Leu  Ile Asn Lys Lys Lys  Leu Asn Tyr Gly Ile  Arg Asn Lys 
    1025                 1030                 1035             


Leu Leu  Leu Ile Arg Asn Ala  Phe Asn His Asn Ser  Tyr Pro Asp 
    1040                 1045                 1050             


Lys Lys  Tyr Ala Glu Val Arg  Glu Leu Pro Glu Ile  Ala Thr Asn 
    1055                 1060                 1065             


Leu Lys  Lys Thr Phe Asp Glu  Asn Ala Lys Lys Tyr  Glu 
    1070                 1075                 1080     


<210>  1507
<211>  1260
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1507

Val Arg His Gln Gly Ala Arg Thr Pro Asp Ala Arg Gln Pro Arg His 
1               5                   10                  15      


Gly Arg His Gly Arg Asn Val Leu Ser Arg Ser Pro Leu Thr Thr Asp 
            20                  25                  30          


Tyr Cys Gly Arg Ala Ala Val Arg Pro Ala Leu Phe Val Ser Pro Leu 
        35                  40                  45              


Gly His Lys Arg Gln Ser Leu Ile Ser Arg Tyr Pro Ser Ile Pro Asn 
    50                  55                  60                  


Ser Phe Met Lys Asn Asp Tyr Asn Ser Asn Ser Pro Lys Lys Thr Val 
65                  70                  75                  80  


Ala Pro Lys His Phe Ala Leu Pro Glu Ala Met Gly Gly Glu Thr Pro 
                85                  90                  95      


Leu Asn Glu Asp Glu Lys Lys Leu Lys Ala Val Ala Gly Thr Tyr Phe 
            100                 105                 110         


Glu Arg Ala Met Asn Asn Ala Ala Gln Thr Leu Arg Tyr Ile Phe Asn 
        115                 120                 125             


Asn Lys Leu Gln Leu Thr Pro Thr Pro Asp Phe Lys Asp Leu Glu Lys 
    130                 135                 140                 


Thr Leu Arg Gly Leu Ala Glu Asn Ser Ala Leu Ala Asp Pro Leu Lys 
145                 150                 155                 160 


His Asp Glu Phe Arg Lys Leu Val Phe His His Ile Pro Leu Phe Lys 
                165                 170                 175     


Ala Leu Glu Asp Tyr Arg Thr Arg Pro Pro Lys Pro Gln Lys Gly Ser 
            180                 185                 190         


Phe Ser Gln Pro Lys Glu Val Arg Lys Leu Tyr Ser Ala Ala Asp Ile 
        195                 200                 205             


Leu Ile Asp Leu Ala Asp Met Val Gly Ala Leu Asn His Tyr Arg Asn 
    210                 215                 220                 


Thr Tyr Thr His Ala Asn His Ser Cys Ser Gln Gln Thr Lys Ala Ala 
225                 230                 235                 240 


Leu Gln Gln Arg Glu Gly Glu Ile Ala Lys Trp Met Glu Asn Val Phe 
                245                 250                 255     


Asp Ser Ala Val Arg Met Thr Lys Glu Arg Cys Gly Phe Ser Ala Asp 
            260                 265                 270         


Gln Met Lys Phe Leu Gln Cys Gly Phe Gly Ser Arg Arg Lys Arg Asp 
        275                 280                 285             


Gly Lys Lys Phe Val Leu Asn Asp Gln Phe Phe Phe Ala Leu Thr Arg 
    290                 295                 300                 


Asn Gly Leu Glu Val Thr Pro Ala Gly Arg Leu Phe Leu Cys Cys Cys 
305                 310                 315                 320 


Phe Leu Pro Ser His Tyr Val Trp Asp Phe Leu Gly Arg Val Asn Leu 
                325                 330                 335     


Glu Arg Thr Thr Pro Phe Asp Gln Asn Gln Arg Asp Ile Leu Ser Arg 
            340                 345                 350         


Ala Leu Asn Val Phe His Leu Arg Leu Pro Gln Glu Asn Arg Ile Glu 
        355                 360                 365             


Ser Asp Thr Ser Glu Gly Gly Leu Leu Leu Asp Val Phe Ala Glu Leu 
    370                 375                 380                 


Gly Arg Cys Pro Leu Arg Glu Val Phe Asp His Ile Ser Pro Gln Gly 
385                 390                 395                 400 


Gln Lys Gln Phe Arg Pro Lys Pro Asp Asp Arg Ser Pro Asp Gly Glu 
                405                 410                 415     


Glu Val Leu Leu Ala Arg Tyr Asp Asp Arg Phe Pro Gln Leu Ala Leu 
            420                 425                 430         


Arg Leu Ile Asp Gln Leu Gly Ile Leu Asp Leu Val Asp Lys Asn Gly 
        435                 440                 445             


Asn Lys Lys Glu Gly Ile Arg Phe Gln Gln Arg Leu Gly Ser Phe Arg 
    450                 455                 460                 


Phe Arg Phe Tyr Asp Lys Arg Cys Val Asp Gly Ala Ser Arg Leu Arg 
465                 470                 475                 480 


Thr Leu Gln Lys Glu Ile Asn Gly Phe Gly Lys Trp His Glu Leu Glu 
                485                 490                 495     


Ser Arg Arg Arg Ser Arg Trp Ala Gly Ile Ile Arg Glu Ser Ala Gln 
            500                 505                 510         


Pro Asp Gln Glu Ser Glu Gly Gly Phe Ala Pro Asp Thr Ala Asp Ser 
        515                 520                 525             


Gln Pro Tyr Val Thr Asp Cys Ala Pro Arg Tyr Asn Ile His Asn Asn 
    530                 535                 540                 


Arg Ile Gly Met Thr Trp Gly Leu Asp Asp Gly Leu Phe Leu Pro Asp 
545                 550                 555                 560 


Leu Pro Lys Ala Ala Glu Asn Pro Gly Ser Val Ala Val Glu Gln Pro 
                565                 570                 575     


Val Pro Lys Cys Ser Met Ser Ile Phe Asp Leu Pro Ala Leu Leu Phe 
            580                 585                 590         


Tyr Arg His Leu Ile Phe Lys Lys Gly Asn Ile Ala Asn Leu Ala Thr 
        595                 600                 605             


Pro Ala Lys Val Ile Gln Asp Cys Cys Asn Asn Leu His Glu Leu Phe 
    610                 615                 620                 


Glu Leu Ala Glu Gln Gly Ala Ser Pro Asp Ala Leu Lys Lys Phe Ala 
625                 630                 635                 640 


Val Asp Lys Gly Ile Ala Asp Ser Ser Ile Pro Val Arg Leu Leu Asn 
                645                 650                 655     


Tyr Ile Asn Gly Asn Pro Cys Gly Pro Gln Asp Arg Leu Ala Ala His 
            660                 665                 670         


Ala Ala Gln Val Leu Gln Glu Val Val Glu Leu Cys Glu Asn Arg Leu 
        675                 680                 685             


Asp Gln Leu Lys Glu Ala Gln Lys Cys Asp Ile Lys Tyr Gly Lys Lys 
    690                 695                 700                 


Gly Cys Arg Gln Val Arg Tyr Gly His Met Ala Gln Tyr Leu Gly Lys 
705                 710                 715                 720 


Ser Ile Met Arg Trp Gln Pro Pro Arg Pro Gly Gly Gln Asn Lys Leu 
                725                 730                 735     


Thr Gly Leu Asn Tyr Gln Thr Leu Val Lys Ala Leu Ala Thr Ser Gly 
            740                 745                 750         


Gln Ser Trp Asn Asp Arg Glu Val Asn Gln Leu Phe Gln Asn Ser Glu 
        755                 760                 765             


Leu Leu Gly Ser Asp His Pro His Pro Phe Leu Ala Glu Ala Leu Arg 
    770                 775                 780                 


Gly Thr Gln Asn Leu Gly His Phe Tyr Ser Arg Tyr Leu Ala Arg Glu 
785                 790                 795                 800 


Lys Thr Phe Ala Leu Lys Met Lys Ala Glu Leu Glu Ala Arg Pro Ala 
                805                 810                 815     


Glu Ala Leu Arg Gln Val Pro Phe Ala Lys Pro Asp Ala Ala Lys Trp 
            820                 825                 830         


Lys Asp Cys Gln Ser His Pro Asp Tyr Ile Lys Asp Tyr Ala Arg Arg 
        835                 840                 845             


Leu Leu His Thr Pro Ala Gly Gly Lys Glu Thr Pro Ala Ile Leu Leu 
    850                 855                 860                 


Leu Pro Asp Gly Leu Phe Asp Ala His Val Arg Lys Ala Ile Thr Ala 
865                 870                 875                 880 


Phe Leu Pro Asn Thr Glu Leu Cys Gln Met Ala Asn Glu Lys Val Pro 
                885                 890                 895     


Gly Asn Asn Glu Lys Val Pro Gly Asn Glu Cys Cys Tyr Lys Tyr Gly 
            900                 905                 910         


Ile Ser Lys Leu Ile Ala Gln Tyr Phe Glu Gln Val Gln Asn Asp Tyr 
        915                 920                 925             


Ala Gln Pro Phe Tyr Asn Ala Asp Met Pro Asp Phe Gly Arg Ala Tyr 
    930                 935                 940                 


Ser Leu Thr Thr Lys Leu Tyr Gly Gln Lys Val Gly Asn Ser His Gln 
945                 950                 955                 960 


Pro Tyr Tyr Met Asn Ser Ala Asn Leu Lys Thr Ala Val Ala Lys Cys 
                965                 970                 975     


Gly Ala Glu Thr Val Arg Arg Ala Val Asp Met Lys Ala Ala Gln Thr 
            980                 985                 990         


Glu Glu Ser Ala Lys Arg Lys Leu  Arg Ser Ile Leu Asn  Asn Glu Lys 
        995                 1000                 1005             


Ala Ile  Arg Arg Leu Met Thr  Gln Asp Lys Val Leu  Phe Leu Thr 
    1010                 1015                 1020             


Ala Lys  Glu Leu Leu Tyr Ser  Leu Leu Thr His Glu  Trp Phe Asn 
    1025                 1030                 1035             


Tyr Tyr  Thr Lys Pro Ala Asn  Thr Ser Val Leu Gln  Gln Ile Asn 
    1040                 1045                 1050             


Ser Val  Gln Leu Gln Ser Ala  Asp Ser Asp Phe Leu  Arg Gln Cys 
    1055                 1060                 1065             


Ser Gln  Ile Ile Gly Asp Asp  Gln Leu Pro Thr Phe  Arg Phe Lys 
    1070                 1075                 1080             


Leu Lys  Asn Ser Asp Val Thr  Ile Thr Gln Glu Asn  Leu Ser Leu 
    1085                 1090                 1095             


Arg Asn  Met Gly Asn Val Tyr  Arg Val Gln Arg Asp  Pro Arg Trp 
    1100                 1105                 1110             


Gln Thr  Leu Gln Lys Leu Leu  Glu Lys Leu Glu Gln  Thr Glu Val 
    1115                 1120                 1125             


Gln Tyr  Gly Ala Ile Thr Ala  Glu Phe Lys Asn His  Glu Glu Asn 
    1130                 1135                 1140             


Ser Val  Lys Ala Val Glu Leu  Ser Gln Arg Leu Glu  His Glu Ala 
    1145                 1150                 1155             


Tyr Ser  Asp Ala Ile Gly Arg  Gly Glu Thr Ile Asp  Glu Glu Thr 
    1160                 1165                 1170             


Ser His  Asn Phe Arg Lys Leu  Leu Val Cys His Pro  Thr Leu Ser 
    1175                 1180                 1185             


Lys Tyr  Gln Cys Asp Glu Ile  Val Leu Val Arg Asn  Lys Phe Asn 
    1190                 1195                 1200             


His Asn  Gln Tyr Val Asp Pro  Ser Ile Ser Lys Asp  Lys Ile Phe 
    1205                 1210                 1215             


Ile Glu  Arg Asn Met Asn Gly  Lys Lys Val Pro Asn  Leu Ala Lys 
    1220                 1225                 1230             


Ala Met  Tyr Glu Thr Met Lys  Glu Ala Val Glu His  Pro Glu Asp 
    1235                 1240                 1245             


Ile Ile  Arg Lys Glu Val Gly  Glu Val Ser Gly Gly  
    1250                 1255                 1260 


<210>  1508
<211>  1176
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1508

Met Asn Ile Ile Asp Thr Tyr Met Pro Ile Asn Ser Ala Glu Lys Ile 
1               5                   10                  15      


Asp Lys Leu Ile Glu Ala Leu Lys Gly Ile Pro Gly Ala Met Asn Pro 
            20                  25                  30          


Asn Asn Arg Asn Tyr Ile Phe Gln Asn Ile Gly Lys Ala Lys Leu Gln 
        35                  40                  45              


Ile Tyr Phe Asn Asp Lys Tyr Pro Glu Ser Ile Phe Thr Glu Asp Ser 
    50                  55                  60                  


Val Ser Leu Pro Glu Ile Ser Ser Ser Val Ser Val Gly Lys Ser Ser 
65                  70                  75                  80  


Ile Glu Thr Lys Glu Glu Glu Gln Pro Ile Pro Val Pro Lys Glu Thr 
                85                  90                  95      


Leu Gly Ser Lys Lys Tyr Ile Tyr Gly Thr Tyr Ile Glu Met Ala Phe 
            100                 105                 110         


His Asn Leu Phe Leu Asn Ile Glu His Ile Tyr Ala Ile Val Thr Gly 
        115                 120                 125             


Lys Ser Ile Met Glu Glu Ala Lys Ala Lys Phe Ile Pro Lys Gly Lys 
    130                 135                 140                 


His Pro Phe Phe Asp Gly Asp Phe Ala Asn Glu Ser Leu Val Trp Lys 
145                 150                 155                 160 


Pro Met Phe Asn Thr Phe Arg Asn Ser Asn Ser Glu Asp Thr Leu Lys 
                165                 170                 175     


Ile Glu Glu Met Leu Asn Arg His Phe Pro Phe Leu Val Pro Phe Arg 
            180                 185                 190         


Asp Tyr Ile Gln Gln Ser Lys Tyr Tyr Asn Lys Leu Thr Ser Val Asp 
        195                 200                 205             


Ile Leu Glu Arg Leu Ser Gln Thr Leu Arg Val Leu Arg Asn Val Tyr 
    210                 215                 220                 


Ala His Tyr Lys Ile Thr Leu Tyr Asp Asn Gln Arg Asn Val Tyr Leu 
225                 230                 235                 240 


Gln Asn Glu Lys Leu Ile Phe Glu Cys Leu Asp Arg Cys Phe Leu Gly 
                245                 250                 255     


Ala Arg Arg Ile Val Lys Glu Arg Phe Ala Phe Asp Asp Arg Ala Met 
            260                 265                 270         


His Cys Thr Glu Gln Tyr Glu Phe His Ile Asp Lys Ser Lys Arg Asp 
        275                 280                 285             


Glu Arg Asn Arg Pro Ile Lys Ile Lys Lys Glu Ile Pro Gly Phe Arg 
    290                 295                 300                 


Tyr Lys Leu Tyr Thr Ala Asn Gln Ala Glu Lys His Ile Thr Ser Phe 
305                 310                 315                 320 


Gly Leu Val Phe Leu Thr Ser Leu Phe Leu Glu Lys Lys Tyr Ser Lys 
                325                 330                 335     


Val Met Ser Asp Lys Leu Arg Val Val Ala Lys Gln Asp Glu Ser Val 
            340                 345                 350         


Val Cys Glu Met Leu Ala Val Tyr Arg Leu Arg Leu Asn Ser Gln Arg 
        355                 360                 365             


Ile Asn Val Thr Lys Lys Thr Glu Ala Leu Ala Leu Asp Ile Ile Asn 
    370                 375                 380                 


Glu Val Gln Arg Cys Pro Lys Glu Leu Phe Asp Ile Leu Pro Pro Ser 
385                 390                 395                 400 


Lys Gln Ala Met Phe Arg Val Lys Ser Asp Thr Glu Asp Glu His Glu 
                405                 410                 415     


Val Leu Met Ile Arg His Ser Asn Arg Phe Ala Gln Leu Val Met Lys 
            420                 425                 430         


Tyr Ile Asp Asp Ala His Leu Phe Asp Asn Leu Arg Phe Gln Val Ser 
        435                 440                 445             


Leu Gly Arg Tyr Phe Tyr Lys Phe Tyr Asp Lys Lys Cys Ile Asp Ser 
    450                 455                 460                 


His Glu Asn Thr Arg Val Arg Ala Ile Cys Lys Asn Val Asn Gly Phe 
465                 470                 475                 480 


Gly Arg Ile Glu Glu Ile Glu Lys Met Arg Gln Gly Cys Trp Asp Asp 
                485                 490                 495     


Val Leu Arg Gln Tyr Glu Asp Val His Lys Asn Thr Ser Asp Glu Lys 
            500                 505                 510         


Pro Tyr Val Thr Asp His His Ala Gln Tyr Ile Ile Thr Gly Asn Arg 
        515                 520                 525             


Ile Gly Met Arg Phe Met Asp Asp Ala Val Lys Cys Tyr Leu Pro Glu 
    530                 535                 540                 


Leu Thr Thr Asp Gly Val Arg Asn Leu Pro Pro Thr Cys Trp Met Ser 
545                 550                 555                 560 


Thr Tyr Glu Leu Pro Ala Leu Met Phe Leu Leu His Leu Thr Asp Asp 
                565                 570                 575     


Ala Thr Arg Ile Glu Asp Ile Ile Arg Ser Thr Val Asn Asn Tyr Thr 
            580                 585                 590         


Arg Phe Phe Asn Asp Ile Glu Leu Gly Lys Leu Leu Pro Thr Asp Asp 
        595                 600                 605             


Val Ala Thr Leu Glu Ala Thr Leu Asn Lys Asp Tyr Gly Ile Ser Ser 
    610                 615                 620                 


Leu Lys Asp Ile Pro Gln Asn Met Val Asp Tyr Leu Leu Gly His Asn 
625                 630                 635                 640 


Thr Glu Ala Arg Asp Lys Phe Val Glu Ser Ala Asn Ala Thr Leu Asp 
                645                 650                 655     


Arg Leu Ile Ala Gln Thr Glu Tyr Lys Ile Ser Lys Tyr Lys Asp Glu 
            660                 665                 670         


Lys Lys Leu Leu Gly Val Asn His Lys Glu Asn Lys Ile Gly Lys Lys 
        675                 680                 685             


Ser Tyr Val Gln Ser Lys Pro Gly Ala Leu Ala Phe Phe Leu Ala Lys 
    690                 695                 700                 


Asp Ile Met Phe Phe Gln Pro Asn Asp Glu Gln Gly Arg Asn Lys Leu 
705                 710                 715                 720 


Thr Gly Leu Asn Phe Arg Ile Leu Gln Ala Val Leu Ala Thr Phe Lys 
                725                 730                 735     


Asn Gly Glu Thr Asp Glu Leu Lys Arg Thr Leu Glu Ser Ala His Ile 
            740                 745                 750         


Ile Gly Lys Arg Asp Asp Asp Met Cys Asn Pro Ile Val Gln Arg Leu 
        755                 760                 765             


Trp Ser Asp Ser Val His Pro Ser Cys Thr Gln Asp Phe Tyr Glu Met 
    770                 775                 780                 


Tyr Leu Ile Glu Arg Leu Ser Tyr Leu Lys Glu Cys Lys Arg Arg Gly 
785                 790                 795                 800 


Asn Leu Glu Arg Leu Ser Phe Leu Tyr Pro Asn Arg Met Lys Trp Gln 
                805                 810                 815     


Ile His Asp Glu Glu Phe Ser Arg Ser Gln Ala Gly Arg Tyr Leu His 
            820                 825                 830         


Asp Ser Tyr Gly Asn Val Lys Cys Asp Lys Ala Ile Glu Leu Pro Arg 
        835                 840                 845             


Gly Leu Phe Glu Lys His Ile Arg Glu Glu Leu Lys Ser Ile Pro Leu 
    850                 855                 860                 


Met Lys Ala Leu Ala Glu Asp Thr Ser Lys Asn Ile Ser Tyr Leu Ile 
865                 870                 875                 880 


Tyr Gly Tyr Phe Met Lys Val Met Asn Asp Asp Cys Gln Asn Phe Tyr 
                885                 890                 895     


Glu Ala Glu Arg Ser Tyr Gln Leu Phe Asn Val Leu Tyr Lys Lys Ser 
            900                 905                 910         


Pro Arg Asp Ser Lys Gln Tyr Arg Thr Thr Asp Asp Ile Arg Leu Met 
        915                 920                 925             


Leu Asn Arg Lys His Thr Thr Ser Ile His Lys Asp Ile Lys Gln Tyr 
    930                 935                 940                 


Leu Glu Arg Leu Asn Pro Lys Asn Tyr Lys Lys Glu Ser Glu Lys Ile 
945                 950                 955                 960 


Gln Gly Leu Leu Arg Arg Leu Lys Asp Asn Glu Thr Ile Leu Lys Thr 
                965                 970                 975     


Tyr Lys Val Gln Asp Met Leu Leu Leu Leu Ile Ala Lys Lys Ile Phe 
            980                 985                 990         


Met Ser Asn Val Asp Asp Pro Val  Gln Ala Ala Ala Phe  Glu Gln Ile 
        995                 1000                 1005             


Arg Leu  Arg Asp Ile Gln Asn  Gly Glu Thr Leu Thr  His Lys Ile 
    1010                 1015                 1020             


Lys Met  Cys Val Arg Val Cys  Ser Lys Asn Gly Tyr  Gly Lys Val 
    1025                 1030                 1035             


Ile Lys  Lys Asp Asp Leu Met  Leu Lys His Tyr Ala  Asn Phe Tyr 
    1040                 1045                 1050             


His Ile  Leu Ser Asp Arg Arg  Leu Pro Thr Leu Leu  Asp Leu Val 
    1055                 1060                 1065             


Arg Gly  Ser Val Val Glu His  Ser Tyr Ile Glu Ser  Glu Leu Ser 
    1070                 1075                 1080             


Gly Tyr  Asp Lys Val Arg Pro  Gly Ile Leu Glu Glu  Val Phe Gly 
    1085                 1090                 1095             


Tyr Glu  Lys Glu Tyr Tyr Gln  Gln Asn Pro Asp Ala  Glu Ala Thr 
    1100                 1105                 1110             


Asp Phe  Gly Tyr Ile Val Asn  Gln Ser Ala Asp Leu  Ser Gln Glu 
    1115                 1120                 1125             


Lys Arg  Asn Ser Leu Arg Asn  Ile Arg Asn Ser Phe  Ala His Asn 
    1130                 1135                 1140             


Thr Tyr  Pro Lys Tyr Lys Asp  Val Gln Ile Ala Gly  Glu Ile Glu 
    1145                 1150                 1155             


Leu Pro  Lys Lys Ala Ile Ala  Ile Ser Glu Lys Phe  Lys Asn Asp 
    1160                 1165                 1170             


Ile Lys  Lys 
    1175     


<210>  1509
<211>  1128
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1509

Met Ile Ser Glu Ser Asn Leu Arg Pro Ile Leu Gly Ala Tyr Ile Asn 
1               5                   10                  15      


Leu Ala Arg Asn Asn Phe Phe Thr Thr Leu Lys His Ile Asn Thr Ala 
            20                  25                  30          


Val Gly Ala Ser Gly Gly Val Asp Asp Asn Glu Ala Gln Met Tyr Leu 
        35                  40                  45              


Met Ser Ile Leu Lys Ser Thr Leu Thr Pro Glu Gln Glu Asp Arg Ala 
    50                  55                  60                  


Arg Arg Leu Phe Phe Leu His Phe Pro Phe Leu Lys Tyr Leu Ser Ser 
65                  70                  75                  80  


Asp Lys Glu Asp Leu Thr Val Ser Phe Gly Arg Met Arg Thr Glu Ile 
                85                  90                  95      


Ile Ser Cys Ala Asn Val Leu Ser Trp Tyr Arg Asn Ile Tyr Ser His 
            100                 105                 110         


Ser Arg Ala Lys Glu Arg Arg Ser Asp Pro Lys Lys Ser Asp Val Ala 
        115                 120                 125             


Asn Asn Tyr Glu Arg Leu Arg Trp Asp Glu Leu Arg Val Cys Arg Leu 
    130                 135                 140                 


Met Ala Gln Thr Ala Thr Val Ser Ala Arg Ile Ile Lys Glu Arg Tyr 
145                 150                 155                 160 


Ser Thr Lys Asn Glu Ser Gln Lys Gly Met Leu Ala Asp Asp Ser Met 
                165                 170                 175     


Asn Phe Ile Asn Arg Asp Arg Tyr Arg Pro Ser Arg Gly Ser Asp Gly 
            180                 185                 190         


Arg Arg Thr Met Ile Leu Asn Glu Ser His Phe Leu Tyr Pro Met Arg 
        195                 200                 205             


Lys Gly Asp Pro Leu Pro Cys Gly Glu Asn Pro Glu Arg Leu Ser Val 
    210                 215                 220                 


Ser Gly Lys Ile Gln Leu Ile Cys Leu Phe Leu Glu Lys Lys Tyr Ile 
225                 230                 235                 240 


Thr Glu Phe Leu Ser Gln Thr Lys Phe Leu Ser Asp Phe Ser Asp Asn 
                245                 250                 255     


Ala Gln Ala Pro Leu Leu Ser Lys Arg Arg Leu Ala Leu Asp Thr Ile 
            260                 265                 270         


Ser Ala Leu Arg Val Arg Leu Pro Glu Ser Arg Ile Gln Ser Asp Arg 
        275                 280                 285             


Asp Glu Thr Gln Val Ala Leu Asp Ile Leu Gly Glu Leu Lys Lys Cys 
    290                 295                 300                 


Pro Ala Glu Ile Tyr Glu Leu Leu Ser Ala Lys Asp Lys Ser Val Phe 
305                 310                 315                 320 


Ser Val Gln Ser Ser Thr Gly Glu Thr Val Leu Leu Arg Arg Ser Ser 
                325                 330                 335     


Asp Arg Phe Val Pro Leu Ala Leu Ser Phe Leu Asp Thr Thr Glu Ala 
            340                 345                 350         


Phe Pro Asn Leu Arg Phe Gln Val Asn Ala Gly Thr Phe Arg Tyr Leu 
        355                 360                 365             


Phe Lys Glu Asp Lys Lys Cys Val Asp Gly Gln Glu Arg Met Arg Val 
    370                 375                 380                 


Leu Gln Glu Pro Leu Asn Cys Phe Gly Arg Ile Gln Glu Val Glu Ala 
385                 390                 395                 400 


Val Arg Lys Ala Lys Asp Gly Arg Leu Trp Lys Glu Tyr Arg Ile Leu 
                405                 410                 415     


Gly Phe Lys Glu Ser Ala Arg Asn Asp Lys Ser Cys Leu Pro Tyr Ile 
            420                 425                 430         


Ser Asp Val Tyr Thr Arg Tyr Val Val Asn Gly Asp Asn Ile Gly Met 
        435                 440                 445             


Arg Leu Asp Gly Thr Ser Ile Pro Glu Ile Lys Leu Arg Asp Asp Gly 
    450                 455                 460                 


Ile Arg Tyr Asp Val Pro Cys Leu Gln Ala Asp Cys Thr Ile Ser Arg 
465                 470                 475                 480 


Phe Asn Leu Gln Ala Met Leu Phe Tyr His Leu Leu Arg Pro Met Ala 
                485                 490                 495     


Lys Asn Ala Val Pro Ser Ala Glu Glu Leu Val Cys Arg Ser Val Glu 
            500                 505                 510         


Ala Tyr Lys His Phe Phe Ser Asp Ile Val Glu Gly His Leu Val Pro 
        515                 520                 525             


Ile Ser Gly Pro Asp Ala Glu Lys Arg Leu Leu Lys Ile Leu Phe Asp 
    530                 535                 540                 


Ser Tyr Gly Ile Lys Leu Tyr Asp Ile Pro Glu Lys Leu Lys Asp Tyr 
545                 550                 555                 560 


Leu Leu Cys Val Pro Asp Arg Lys Asn Arg Phe Glu Lys His Lys Lys 
                565                 570                 575     


Asn Leu Ile Lys Lys Met Leu Glu Asp Thr Gln Arg Arg Leu Glu Arg 
            580                 585                 590         


Ile Ile Glu Gln Arg Ser Thr Ile Glu Glu Asn Gly Ser Glu Asn Lys 
        595                 600                 605             


Pro Gly Lys Lys Gly Tyr Val Gln Ile Lys Pro Gly Gly Leu Ala Ser 
    610                 615                 620                 


Tyr Leu Ala Glu Asp Ile Ala Leu Leu Gln Asp Cys Glu Asp Lys Leu 
625                 630                 635                 640 


Thr Gly Leu Asn Tyr Ala Val Met Gln Gly Thr Met Ala Thr Phe Ser 
                645                 650                 655     


Thr His Glu Pro Asn Gly Lys Gly Asp Leu Ile Lys Ile Phe Lys Asn 
            660                 665                 670         


Ala Gly Leu Ile Ser Ile Asp Gly Lys Ala Gly Ser His Pro Phe Leu 
        675                 680                 685             


Trp Ala Val Met Lys Glu Pro Thr Val Thr Gly Thr Val Asn Leu Tyr 
    690                 695                 700                 


Ile Lys Tyr Leu Arg Ala Lys Ile Asp Tyr Leu Lys Lys Ser Val Ala 
705                 710                 715                 720 


Asp Asn Ala Pro Phe Leu His Ser Glu Arg Lys Arg Trp Glu Glu Arg 
                725                 730                 735     


Asn Val Glu Tyr Tyr Lys Asp Leu Ala Lys Arg Tyr Leu Ser Gln Pro 
            740                 745                 750         


Val Ala Leu Thr Gly Ser Val Phe Glu Gly Pro Val Lys Asp Ile Leu 
        755                 760                 765             


Met Asn Leu Lys Asn Glu Asp Leu Ser Asn Thr Ile Glu Lys Ser Val 
    770                 775                 780                 


Ser Asn Gly Arg Cys Asn Met Ala Tyr Met Ile Gln Gln Phe Gln Asp 
785                 790                 795                 800 


Ile Val Leu Glu Asp Thr Pro Gln Arg Phe Tyr Gly Leu Val Glu Gly 
                805                 810                 815     


Asp Met Glu His Asp Pro Asn Tyr Lys Leu Tyr Gly Leu Ala Arg Lys 
            820                 825                 830         


Tyr Pro Arg Glu Thr Ile Ile Ile Arg Asp Lys Pro Asp Thr Gly Thr 
        835                 840                 845             


Val Phe Lys Ala Thr Leu Asn Arg Ala Ile Leu Trp Val Arg Glu His 
    850                 855                 860                 


Pro Glu Glu Thr Ala Pro Thr Arg Met Gln Asn Gly Pro Arg Pro Ala 
865                 870                 875                 880 


Phe Glu Glu Ile Gln Ala Arg Ile Arg Ala Ala Tyr Lys Glu Phe Thr 
                885                 890                 895     


Glu Thr Glu Lys Leu Ile Arg Arg Leu Ala Thr Gln Asp Thr Leu Leu 
            900                 905                 910         


Phe Met Ala Ser Ser Ser Leu Ile Lys Lys Ile Leu Gly Leu Pro Arg 
        915                 920                 925             


Glu Asp Thr Ser Met Lys Gln Tyr Gln Ile Gly Leu Pro Glu Glu Lys 
    930                 935                 940                 


Gly Ile Leu Asp Met Arg Leu Pro Lys Val Val Lys Asn Val Arg Phe 
945                 950                 955                 960 


Asp Trp Lys Asp Ser Thr Arg Asn Asp Asp Pro Leu Ala His Lys Asn 
                965                 970                 975     


Ala Ser Ile Glu Ala Glu Asp Ile Cys Ile Lys Asp Tyr Gly Asp Ile 
            980                 985                 990         


Phe Arg Ile Ile Asn Asp Arg Arg  Val Ala Ser Leu Val  His His Leu 
        995                 1000                 1005             


Asn Ile  Ser Ser Ile Ser Ile  Asp Asp Leu Arg Lys  Glu Leu Asp 
    1010                 1015                 1020             


Cys Tyr  Asp Asn Arg Arg Val  Asp Ile Phe Arg Asp  Ile Phe Glu 
    1025                 1030                 1035             


Tyr Glu  Asp Lys Val Leu Gly  Ser Val Ser Val Leu  Pro Glu Thr 
    1040                 1045                 1050             


Leu Asp  Phe Asp Ala Val Gln  Lys Cys Asp Thr Thr  Asn Ser Pro 
    1055                 1060                 1065             


Glu Asp  Lys Phe Ala Ala Gly  Ile Ile Arg Asn Ser  Phe Cys His 
    1070                 1075                 1080             


Asn Phe  Tyr Pro Thr Arg Thr  Ala Gly Ser Lys Gln  Lys Lys Val 
    1085                 1090                 1095             


Gln Asp  Val Val Ile Ile Asp  Ser Pro Ile Pro Asp  Val Ala Glu 
    1100                 1105                 1110             


Ser Met  Ala Ser Arg Leu Ala  Asn Phe Ser Lys Lys  Thr Gln Lys 
    1115                 1120                 1125             


<210>  1510
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1510

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Thr 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1511
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1511

Leu Gln Lys Gln Asp Lys Leu Phe Val Asp Arg Lys Lys Asn Ala Ile 
1               5                   10                  15      


Phe Ala Phe Pro Lys Tyr Ile Thr Ile Met Glu Asn Lys Lys Lys Pro 
            20                  25                  30          


Glu Pro Ile Tyr Tyr Glu Leu Thr Asp Lys His Phe Trp Ala Ala Phe 
        35                  40                  45              


Leu Asn Leu Ala Arg His Asn Val Tyr Thr Thr Val Asn His Ile Asn 
    50                  55                  60                  


Lys Leu Leu Glu Ile Ala Glu Leu Lys Asn Asp Glu Asp Val Leu Asn 
65                  70                  75                  80  


Ile Lys Asp Ser Trp Asn Lys Gln Ala Glu Lys Leu Asp Lys Lys Val 
                85                  90                  95      


Arg Leu Arg Asp Leu Ile Met Lys His Phe Pro Phe Leu Glu Ala Ala 
            100                 105                 110         


Ala Tyr Glu Ile Thr Asn Ser Lys Ser Pro Asn Asn Lys Glu Gln Arg 
        115                 120                 125             


Glu Lys Glu Gln Ser Glu Ala Leu Ser Leu Asn Asn Leu Lys Asn Val 
    130                 135                 140                 


Leu Phe Ile Phe Leu Glu Lys Leu Gln Val Leu Arg Asn Tyr Tyr Ser 
145                 150                 155                 160 


His Tyr Lys Tyr Ser Glu Glu Ser Pro Lys Pro Ile Phe Glu Thr Ser 
                165                 170                 175     


Leu Leu Lys Asn Met Tyr Lys Val Phe Asp Ala Asn Val Arg Leu Val 
            180                 185                 190         


Lys Arg Asp Tyr Met His His Glu Asn Ile Asp Met Gln Arg Asp Phe 
        195                 200                 205             


Thr His Leu Asn Arg Lys Lys Gln Val Gly Arg Thr Lys Asn Ile Ile 
    210                 215                 220                 


Asp Ser Pro Asn Phe His Tyr His Phe Ala Asp Lys Glu Gly Asn Met 
225                 230                 235                 240 


Thr Ile Ala Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Asp Lys Lys 
                245                 250                 255     


Asp Ala Ile Trp Met Gln Lys Lys Leu Lys Gly Phe Lys Asp Gly Arg 
            260                 265                 270         


Asn Leu Arg Glu Gln Met Thr Asn Glu Val Phe Cys Arg Ser Arg Ile 
        275                 280                 285             


Ser Leu Pro Lys Leu Lys Leu Glu Asn Val Gln Thr Lys Asp Trp Met 
    290                 295                 300                 


Gln Leu Asp Met Leu Asn Glu Leu Val Arg Cys Pro Lys Ser Leu Tyr 
305                 310                 315                 320 


Glu Arg Leu Arg Glu Lys Asp Arg Glu Ser Phe Lys Val Pro Phe Asp 
                325                 330                 335     


Ile Phe Ser Asp Asp Tyr Asn Ala Glu Glu Glu Pro Phe Lys Asn Thr 
            340                 345                 350         


Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe 
        355                 360                 365             


Asp Leu Asn Glu Ile Phe Glu Gln Leu Arg Phe Gln Ile Asp Leu Gly 
    370                 375                 380                 


Thr Tyr His Phe Ser Ile Tyr Asn Lys Arg Ile Gly Asp Glu Asp Glu 
385                 390                 395                 400 


Val Arg His Leu Thr His His Leu Tyr Gly Phe Ala Arg Ile Gln Asp 
                405                 410                 415     


Phe Ala Gln Gln Asn Gln Pro Glu Val Trp Arg Lys Leu Val Lys Asp 
            420                 425                 430         


Leu Asp Tyr Phe Glu Thr Ser Gln Lys Pro Tyr Ile Ser Lys Thr Ala 
        435                 440                 445             


Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Lys Phe Cys Ser 
    450                 455                 460                 


Thr His Asn Asn Leu Phe Pro Ser Leu Lys Arg Glu Lys Thr Cys Asn 
465                 470                 475                 480 


Gly Arg Ser Lys Phe Asn Leu Gly Thr Gln Phe Thr Ala Glu Ala Phe 
                485                 490                 495     


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu 
            500                 505                 510         


Thr Lys Asp Tyr Ser Arg Lys Glu Ser Ala Asp Lys Val Glu Gly Ile 
        515                 520                 525             


Ile Arg Lys Glu Ile Ser Asn Ile Tyr Ala Ile Tyr Asp Ala Phe Ala 
    530                 535                 540                 


Asn Asn Glu Ile Asn Ser Ile Ala Asp Leu Thr Cys Arg Leu Gln Lys 
545                 550                 555                 560 


Thr Asn Ile Leu Gln Gly His Leu Pro Lys Gln Met Ile Ser Ile Leu 
                565                 570                 575     


Glu Gly Arg Gln Lys Asp Met Glu Lys Glu Ala Glu Arg Lys Ile Gly 
            580                 585                 590         


Glu Met Ile Asp Asp Thr Gln Arg Arg Leu Asp Leu Leu Cys Lys Gln 
        595                 600                 605             


Thr Asn Gln Lys Ile Arg Ile Gly Lys Arg Asn Ala Gly Leu Leu Lys 
    610                 615                 620                 


Ser Gly Lys Ile Ala Asp Trp Leu Val Ser Asp Met Met Arg Phe Gln 
625                 630                 635                 640 


Pro Val Gln Lys Asp Thr Asn Asn Ala Pro Ile Asn Asn Ser Lys Ala 
                645                 650                 655     


Asn Ser Thr Glu Tyr Arg Met Leu Gln His Ala Leu Ala Leu Phe Gly 
            660                 665                 670         


Ser Glu Ser Ser Arg Leu Lys Ala Tyr Phe Arg Gln Met Asn Leu Val 
        675                 680                 685             


Gly Asn Ala Asn Pro His Pro Phe Leu Ala Glu Thr Gln Trp Glu His 
    690                 695                 700                 


Gln Asn Asn Ile Leu Ser Phe Tyr Arg Lys Tyr Leu Glu Ala Arg Lys 
705                 710                 715                 720 


Lys Tyr Leu Lys Gly Leu Lys Pro Gln Asn Trp Lys Gln Tyr Gln His 
                725                 730                 735     


Phe Leu Met Leu Lys Glu Gln Lys Ser Asn Arg Asn Thr Leu Val Ala 
            740                 745                 750         


Gly Trp Lys Asn Gly Phe Asn Leu Pro Arg Gly Ile Phe Thr Glu Pro 
        755                 760                 765             


Ile Arg Lys Trp Phe Glu Glu His Asn Asn Ser Glu Gly Leu Tyr Asp 
    770                 775                 780                 


Gln Ile Leu Ser Phe Gly Arg Val Gly Phe Val Ala Lys Ala Ile Pro 
785                 790                 795                 800 


Leu Tyr Phe Ala Glu Glu Cys Lys Asp Cys Val Gln Pro Phe Tyr Asp 
                805                 810                 815     


Tyr Pro Phe Asn Val Gly Asn Lys Leu Lys Pro Lys Lys Gly Gln Phe 
            820                 825                 830         


Leu Asp Lys Lys Asp Arg Val Glu Leu Trp Gln Lys Asn Lys Glu Leu 
        835                 840                 845             


Phe Lys Asn Tyr Pro Ser Glu Lys Lys Lys Thr Asp Leu Ala Tyr Leu 
    850                 855                 860                 


Asp Phe Leu Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys 
865                 870                 875                 880 


Asn Gln Asp Ile Val Thr Trp Leu Met Phe Lys Glu Leu Phe Lys Thr 
                885                 890                 895     


Thr Thr Val Glu Gly Leu Lys Ile Gly Glu Ile His Leu Arg Asp Ile 
            900                 905                 910         


Asp Thr Asn Thr Ala Asn Glu Glu Ser Asn Asn Ile Leu Asn Arg Ile 
        915                 920                 925             


Met Pro Met Lys Leu Pro Val Lys Thr Tyr Glu Thr Asp Asn Lys Gly 
    930                 935                 940                 


Asn Ile Leu Lys Glu Arg Pro Leu Ala Thr Phe Tyr Ile Glu Glu Thr 
945                 950                 955                 960 


Glu Thr Lys Val Leu Lys Gln Gly Asn Phe Lys Val Leu Ala Lys Asp 
                965                 970                 975     


Arg Arg Leu Asn Gly Leu Leu Ser Phe Ala Glu Thr Thr Asp Ile Asp 
            980                 985                 990         


Leu Glu Lys Asn Pro Ile Thr Lys  Leu Ser Val Asp His  Glu Leu Ile 
        995                 1000                 1005             


Lys Tyr  Gln Thr Thr Arg Ile  Ser Ile Phe Glu Met  Thr Leu Gly 
    1010                 1015                 1020             


Leu Glu  Lys Lys Leu Ile Asp  Lys Tyr Ser Thr Leu  Pro Thr Asp 
    1025                 1030                 1035             


Ser Phe  Arg Asn Met Leu Glu  Arg Trp Leu Gln Cys  Lys Ala Asn 
    1040                 1045                 1050             


Arg Pro  Glu Leu Lys Asn Tyr  Val Asn Cys Leu Ile  Ala Val Arg 
    1055                 1060                 1065             


Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met Tyr Asp  Ala Thr Leu 
    1070                 1075                 1080             


Phe Ala  Glu Val Arg Lys Phe  Thr Leu Phe Pro Ser  Val Asp Thr 
    1085                 1090                 1095             


Lys Lys  Ile Glu Leu Asn Ile  Ala Pro Gln Leu Leu  Glu Ile Val 
    1100                 1105                 1110             


Gly Lys  Ala Ile Lys Glu Ile  Glu Lys Ser Glu Asn  Lys Asn 
    1115                 1120                 1125         


<210>  1512
<211>  1094
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1512

Met Glu Ala Asn Glu Gln Asn Gln Glu Asn Arg Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Asn Asn His Ile Ala Ala Asp Phe Gly Gln Ala Val 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ser Gly Phe Leu Cys Asn Lys Glu 
    50                  55                  60                  


Ile Lys Lys Leu Asn Trp Asn His Ile Tyr Ala Lys Thr Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ile Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Val Asn Ser Asp Lys Glu Gly Lys Asp Phe Ala Ala Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Ser Glu Leu Gln Asp Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Glu Asn Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Ala Glu Leu Thr Asp Met Leu Thr Ile Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Thr Asp Ala Asp Tyr 
                165                 170                 175     


Glu Leu Val Glu Thr Lys Gln Val Val Thr Thr Gly Asn Ile Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Met Phe Leu Glu Arg Glu His 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asn Leu Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Gly 
            260                 265                 270         


Val Ile Thr Asp Glu Glu Lys Met Gln Phe Arg Pro Glu Leu Asp Glu 
        275                 280                 285             


Leu Asp Ile Glu Lys Leu Ile Ala Asn Ser Thr Asn Asp Asp Glu Arg 
    290                 295                 300                 


Glu Arg Ile Leu Asp Glu Ile Gly Tyr Glu Glu Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg Tyr Asn Asn Arg Phe Pro Tyr Phe Ala Met Arg 
                325                 330                 335     


Phe Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Arg Tyr Thr Lys Gln Leu Ala Gly Glu 
        355                 360                 365             


Gln Thr Glu Arg Val Val Gln Glu Asn Val Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asp Pro Glu Leu Ile Gln Gln Lys Ile Asp Asn Gln 
385                 390                 395                 400 


Gln Arg Thr Asp Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Ile Ala Ile Leu Ile 
            420                 425                 430         


Pro Lys Ser Lys Pro Glu Ser Lys Val Gly Asn Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Asp Tyr Leu Gln Lys Gly Lys Ala Glu Glu Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Ile Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Leu Lys Leu Pro Ala Asn Trp Asn Glu Phe Ala Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asp Ala Ala Met Glu Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Asp Val Leu Ile Thr Tyr Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Asp Val Glu Asp Asn Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Leu Glu Lys His Lys Leu 
            580                 585                 590         


Asp Lys Ser Val Lys Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Met Val Ser Lys Glu Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Ala Asp Thr Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Val Leu Glu Gly Asp Gly His Pro Phe Leu Thr Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Glu Leu Tyr Met Asn 
        675                 680                 685             


Ala Lys Val Gln Tyr Leu Ile Gln Phe Tyr Lys Pro Ser Lys Asp Lys 
    690                 695                 700                 


Val Asp Lys Arg Gly Arg Pro Thr Thr Glu Val Lys Leu Pro Pro Leu 
705                 710                 715                 720 


Asp Lys Arg Ser Asn Ile Pro Phe Thr Ile Arg Gln Trp Asp Glu Lys 
                725                 730                 735     


Glu Lys Tyr Asn Leu Asn Ala Trp Leu Arg Asn Val Thr Val Gly Lys 
            740                 745                 750         


Asn Thr Lys Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe 
        755                 760                 765             


Asp Glu Thr Leu Cys Asp Leu Leu Ser Gln Gln Leu Asp Ala Arg Thr 
    770                 775                 780                 


Val Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Leu Trp 
785                 790                 795                 800 


Trp Lys Thr Arg Asp Asp Ala Thr Gln Asp Phe Tyr Gln Ser Glu Arg 
                805                 810                 815     


Glu Tyr Asp Ile Tyr Glu Glu Lys Val Glu Phe Lys Ile Asp Ser Ser 
            820                 825                 830         


Gly His Phe Ala Asp Tyr Tyr Lys Lys Ala Leu Ser Lys Ala Tyr Asn 
        835                 840                 845             


Arg Leu Lys Ala Glu Arg Glu Ile Ala Arg Arg Thr Asn Lys Arg Leu 
    850                 855                 860                 


Pro Pro Ile Glu His Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile 
865                 870                 875                 880 


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
                885                 890                 895     


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asp Ser Gly Asn Leu Lys 
            900                 905                 910         


Leu Ser Thr Ile Lys Thr Ser Leu Asn Asn Thr Thr Gln Ile Lys Gln 
        915                 920                 925             


Lys Ile Leu Asn Lys Thr Ile Val Ala Glu Arg Lys Gln Lys Asn Tyr 
    930                 935                 940                 


Thr Glu Leu Arg Lys Tyr Val His Asp Arg Arg Leu Pro Asn Leu Phe 
945                 950                 955                 960 


Glu Tyr Val Glu Ala Asp Glu Ile Leu Leu Glu Trp Leu Leu Asp Glu 
                965                 970                 975     


Leu Met Ala Tyr Asn Ala Ala Lys Gln Gln Val Phe Asp Thr Ile Phe 
            980                 985                 990         


Met Leu Glu Lys Arg Ile Ile Glu  Thr Asp Pro Gln Glu  Leu Lys Ser 
        995                 1000                 1005             


Leu Phe  Thr Asn Glu Lys Gly  Gln Val Gln Thr Gly  Asn Ile Gln 
    1010                 1015                 1020             


His Lys  Pro Tyr Val Gln Trp  Leu Lys Asn Lys Gly  Leu Ile Asn 
    1025                 1030                 1035             


His Asn  Glu Lys Leu Phe Ile  Asn Met Val Arg Asn  Cys Phe Ser 
    1040                 1045                 1050             


His Asn  Gln Phe Pro Gln Arg  Glu Thr Met Glu Leu  Leu Ile Ser 
    1055                 1060                 1065             


Glu Trp  Gly Ala Gly Lys Ile  Ala Thr Gln Ile Leu  Thr Val Tyr 
    1070                 1075                 1080             


Asn Gln  Leu Ile Thr Asn Ile  Ile Asn Lys Ile 
    1085                 1090                 


<210>  1513
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1513

Met Glu Thr Lys Gln Gln Val Gly Lys Gly Ile Ser Tyr Asp His Arg 
1               5                   10                  15      


Arg Pro Asp Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asp Gly Val Ile Gln Glu Phe Ala Met Arg Leu Asn Arg 
        35                  40                  45              


Glu Tyr Asp Pro Glu Asn Lys Asn Gln Ser Leu Phe Ser Tyr Phe Asn 
    50                  55                  60                  


Ile Asn Ala Ser Phe Thr Asp Trp Glu Arg Gly Val Asn Ile Leu Lys 
65                  70                  75                  80  


Glu Tyr Trp Pro Met Met Glu Phe Ile Asp Arg Pro Ala Thr Asp Lys 
                85                  90                  95      


Gln Phe Glu Ala Glu Lys Pro Glu Asn Arg Glu Ala Ala Lys Arg Lys 
            100                 105                 110         


Tyr Phe Leu Ala Thr Leu Gly Ala Leu Leu Thr Ser Ile Lys Asp Leu 
        115                 120                 125             


Arg His Tyr Tyr Thr His Tyr Tyr His Pro Pro Val His Leu Asn Asp 
    130                 135                 140                 


Asp Leu Phe Leu Phe Leu Asp His Ala Leu Leu Tyr Thr Ala Phe Asp 
145                 150                 155                 160 


Val Lys Lys Thr Lys Met Lys Asp Asp Lys Thr Arg Gln Leu Leu Asn 
                165                 170                 175     


Gln Asn Leu Ser Leu Glu Leu Glu Lys Leu Lys Lys Leu Lys Val Glu 
            180                 185                 190         


Glu Leu Lys Lys Lys Lys Glu Lys Gly Ile Lys Val Asn Leu Gln Asp 
        195                 200                 205             


Glu Lys Gly Ile Leu Asn Ala Ile Tyr Asn Asp Ala Phe Ala His Ile 
    210                 215                 220                 


Ile Thr Lys Glu Lys Asp Ser Asp Lys Asp Lys Leu Glu Thr Arg Tyr 
225                 230                 235                 240 


Lys Ser Ile Leu Pro Gln Asp Glu Ala Ala Glu Thr Gly Ile Asn Ile 
                245                 250                 255     


Ser Ile Ser Gly Leu Ile Phe Leu Leu Ser Leu Phe Leu Ser Arg Lys 
            260                 265                 270         


Glu Ile Glu Gln Leu Lys Ser Asn Ile Glu Gly Tyr Lys Gly Lys Val 
        275                 280                 285             


Leu Asn Ile Glu Thr Glu Val Asp Arg Lys His Asn Ser Leu Lys Tyr 
    290                 295                 300                 


Met Ala Thr His Trp Val Phe Ser Ile Leu Ala Phe Lys Gly Leu Lys 
305                 310                 315                 320 


Gln Arg Leu Thr Asn Ser Phe Glu Lys Glu Ser Leu Leu Ile Gln Met 
                325                 330                 335     


Met Asp Glu Leu Asn Lys Val Pro Asp Glu Leu Tyr Gln Thr Leu Ser 
            340                 345                 350         


Glu Thr Ala Lys Lys Glu Phe Leu Glu Asp Ile Asn Glu Tyr Val Ser 
        355                 360                 365             


Glu Gly Asp Asp Asn Glu Lys Ala Thr Tyr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Ser Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gln Phe Pro Thr Leu Lys Phe Gln Ile Phe Val Gly 
                405                 410                 415     


Gln Tyr Leu His Asp Asn Arg Pro Lys Thr Leu Ala Ser Asn Gly Met 
            420                 425                 430         


Thr Ala Gln Arg Met Ile Lys Glu Lys Ile Asn Leu Phe Gly Asn Leu 
        435                 440                 445             


Ser Glu Val Thr Lys His Lys Ser Asp Phe Phe Glu Lys Glu Ser Ala 
    450                 455                 460                 


Ala Gln Gly Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Trp Ala Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Val Tyr Ile Asp Met Ile Gly Lys Glu Gly Lys Ala 
                485                 490                 495     


Lys Glu Ile Gln Val Gln Ile Asn Lys Tyr Arg Lys Gln Leu Asn Pro 
            500                 505                 510         


Ala Pro Gln Arg Asp Lys Arg Ile Ser Lys Lys Glu Ile Ile Glu Gln 
        515                 520                 525             


Leu Tyr Lys Glu Lys Val Val Tyr Gly Asp Pro Thr Leu Met Leu Ser 
    530                 535                 540                 


Ala Asn Glu Leu Met Ala Leu Leu Tyr Glu Leu Ile Val Asn Gly Lys 
545                 550                 555                 560 


Ser Gly Ala Glu Leu Glu Asn Lys Ile Val Glu Gln Ile Ile Ala Arg 
                565                 570                 575     


Tyr Glu Gln Ile Glu Ala Tyr Asp Pro Thr Thr Gln Gln Leu Pro Thr 
            580                 585                 590         


Asn Gln Met Pro His Lys Leu Gln Lys Ser Arg Lys Asp Ser Lys Val 
        595                 600                 605             


Thr Asp Thr Asp Lys Leu Leu Lys Thr Ile Asp Lys Glu Ile Asp Glu 
    610                 615                 620                 


Gly Asn Lys Lys Leu Glu Leu Ile Ala Cys His Arg Lys Glu Trp Glu 
625                 630                 635                 640 


Glu Ala Glu Gln Arg Lys Lys Ser Gly Lys Arg Asn Asn Pro Gly Thr 
                645                 650                 655     


Lys Ser Arg Lys His Leu Phe Tyr Ala Ser Glu Met Gly Glu Glu Ala 
            660                 665                 670         


Thr Trp Ile Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Pro Ala Arg 
        675                 680                 685             


Ala Glu Trp Lys Gly Thr His His Ser Glu Leu Gln Arg Leu Leu Ala 
    690                 695                 700                 


Phe Tyr Ser Thr Gln Arg Leu Glu Ala Trp Gln Leu Val Glu Ser Val 
705                 710                 715                 720 


Trp Thr Ala Asn Thr His Ser Phe Trp Glu Glu Asn Phe Lys Glu Ala 
                725                 730                 735     


Phe Tyr Lys Pro Glu Phe Glu Asn Phe Tyr Gly Ala Tyr Ile Glu Ile 
            740                 745                 750         


Arg Thr Lys Ile Leu Thr Thr Cys Arg Ser Ile Leu Glu Asn Asn Pro 
        755                 760                 765             


Glu Ala Thr Met Asn Asn Asp Thr Glu Lys Glu Trp Asp Lys Val Phe 
    770                 775                 780                 


Thr Leu Phe Asp Lys Arg Leu Tyr Arg Thr Ser Thr Thr Asp Glu Gln 
785                 790                 795                 800 


Lys Lys Gln Leu Leu Thr Lys Pro Phe Ala Phe Pro Arg Gly Leu Phe 
                805                 810                 815     


Asp Asp Lys Pro Thr Phe Leu Pro Gly Ser Lys Pro Asn Glu Asn Pro 
            820                 825                 830         


Glu Arg Phe Ala Ala Trp Tyr Ser Tyr Gly Tyr Thr Tyr Ser Gly Lys 
        835                 840                 845             


Phe Gln Ser Phe Tyr Asp Met Pro Arg Asn Tyr Ser Asp Trp Tyr Lys 
    850                 855                 860                 


Lys Leu Lys Glu Asp Gly Lys Leu Pro Arg Leu Asp Lys Lys Thr Glu 
865                 870                 875                 880 


Gln Glu Lys Ile Leu Arg Phe Arg Met Asp Cys Asp Leu Asn Ile Lys 
                885                 890                 895     


His Ile Arg Phe Gln Asp Ile Tyr Val Lys Leu Met Val Asp Ser Leu 
            900                 905                 910         


Tyr Lys Ala Val Phe Gly Gln Gln Pro Glu Phe Asp Leu Ser His Leu 
        915                 920                 925             


Tyr Asp Thr Arg Ser Glu Arg Tyr Glu Asn Asn Thr Ile Ala Gln Arg 
    930                 935                 940                 


Gln Lys Ser Arg Gln Glu Gly Asp Asn Ser Asp Asn Ala Ile Asn Glu 
945                 950                 955                 960 


Asn Tyr Val Trp Asn Lys Thr Phe Ala Ile Ser Leu Tyr Asn Gly Arg 
                965                 970                 975     


Ile Thr Glu Ser Gln Val Lys Leu Lys Asp Val Gly Lys Phe Arg Arg 
            980                 985                 990         


Phe Ala Thr Asp Pro Arg Val Gln  Thr Leu Ile Ser Tyr  Asp Asp Thr 
        995                 1000                 1005             


Arg Thr  Trp Thr Lys Leu Glu  Ile Glu Asn Glu Leu  Asp Asn Lys 
    1010                 1015                 1020             


Ala Asp  Ala Tyr Glu Pro Ile  Arg Arg Thr Gln Ser  Leu Lys Ala 
    1025                 1030                 1035             


Ile Gln  Gln Leu Glu Lys Asn  Ile Leu Lys Lys Asn  Gly Phe Asn 
    1040                 1045                 1050             


Gly Lys  Gln His Pro Glu Glu  Leu Lys His Asn Gly  Asn Pro Asn 
    1055                 1060                 1065             


Phe Arg  Lys Tyr Ile Ala Asn  Gly Leu Leu Lys His  Arg Thr Asp 
    1070                 1075                 1080             


Ile Arg  Gln Glu Glu Leu Ala  Leu Ile Ser Asp Thr  Glu Phe Gln 
    1085                 1090                 1095             


Glu Ile  Gly Leu Glu Arg Ile  Arg Gln Thr Asn Pro  Leu Ile Gln 
    1100                 1105                 1110             


Lys Ala  Tyr Leu Leu Ile Leu  Leu Arg Asn Lys Phe  Gly His Asn 
    1115                 1120                 1125             


Gln Leu  Pro Asp Gln Glu His  Phe Arg Leu Met Arg  Ser Ile Tyr 
    1130                 1135                 1140             


Pro Tyr  Asn Gln Gln Glu Ser  Tyr Ser Ala Tyr Phe  Asn His Val 
    1145                 1150                 1155             


Ile Thr  Gln Ile Ile Glu Glu  Leu Asn Thr 
    1160                 1165             


<210>  1514
<211>  1140
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1514

Met Glu Asn Asp Gln Gln Ile Leu Glu Asn Arg Arg Arg Thr Leu Ala 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Ser Asn His Leu Ala Thr Ser Phe Glu Gln Lys Ala 
        35                  40                  45              


Leu His Glu Glu Gly Gln Ile Pro Ala Ser Phe Leu Cys Asn Lys Ser 
    50                  55                  60                  


Ile Lys Lys Ile Asn Trp Asn His Val Tyr Ser Lys Ala Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Ile Phe Asp Ala Asp Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Arg Glu Thr Ser Asp Lys Glu Gly Lys Asp Phe Thr Ala Met Asn Glu 
            100                 105                 110         


Thr Leu Lys Leu Val Phe Asp Glu Leu Gln Ala Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Ala Asp Ser Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Val Glu Leu Ala Asp Phe Leu Thr Val Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Ala Asp Asp Asp Tyr 
                165                 170                 175     


Ala Val Val Glu Ser Lys Gln Ile Val Thr Pro Asp Asn Gln Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Ile Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Val Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Leu Ala Tyr Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asp Leu Arg Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Glu 
            260                 265                 270         


Val Ile Thr Glu Glu Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Glu Glu Glu Arg 
    290                 295                 300                 


Glu Lys Ile Leu Asp Glu Ile Asp Tyr Glu Asp Tyr Ile Glu Ser Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg His Ser Asn Arg Phe Pro Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Glu Lys Tyr Asn Lys Gln Phe Asp Gly Glu 
        355                 360                 365             


Ala Thr Glu Arg Lys Val Val Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asn Gln Glu Thr Val Glu Leu Lys Ile Asp Ser Ala 
385                 390                 395                 400 


Gln Arg Thr Asn Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Glu Ala Arg Leu Leu 
            420                 425                 430         


Thr Lys Ala Lys Pro Glu Ser Lys Val Ser Tyr Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Lys Ala Glu Glu Met Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Lys Val Asn Asp Ser Gln Leu Met Asn Met Gln Phe Ile Asp Glu 
                485                 490                 495     


Ile Lys Glu Gln Leu Pro Ala Asp Trp Asn Glu Phe Gly Lys Arg Ser 
            500                 505                 510         


Asp Ser Lys Lys Lys Lys Ala Tyr Thr Asn Ala Ala Arg Gln Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Lys Val Leu Ala Asn Tyr Gln Leu 
    530                 535                 540                 


Asn Asp Lys Gln Val Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Val 
545                 550                 555                 560 


Lys Glu Val Asp Asp Ser Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Met Glu Lys His Lys Val 
            580                 585                 590         


Asp Lys Ser Ala Arg Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Thr Asp Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Tyr 
625                 630                 635                 640 


Ala Asp Asn Glu Lys Lys Ala Thr Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Lys Asp Gly His Pro Phe Leu Ala Asn Ile Asn 
            660                 665                 670         


Leu Arg Gln Ile Arg Lys Thr Ser Gln Leu Tyr Glu Leu Tyr Leu Val 
        675                 680                 685             


Glu Lys Ala Asn Lys Gln Val Lys Lys Met Asn Pro Lys Thr Gln Arg 
    690                 695                 700                 


Thr Asn Asn Val Asp Glu Ser Trp Met Met Lys Ser Phe Tyr Ala Lys 
705                 710                 715                 720 


Glu Trp Asn Glu Glu Met Gly Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Thr Asn Ile Pro Phe Thr Ile Arg Gln Trp Glu Glu Lys 
            740                 745                 750         


Glu Lys His Asn Leu Gln Ala Trp Leu His Asn Ile Thr Lys Gly Lys 
        755                 760                 765             


Thr Ser Lys Asp Gly Lys Lys Ala Val Asp Leu Pro Thr Asn Leu Phe 
    770                 775                 780                 


Asp Asp Thr Leu Cys Glu Leu Leu Arg Glu Ala Leu Ile Asn Glu Gly 
785                 790                 795                 800 


Ile Asp Ala Thr Pro Thr Thr Lys Tyr Asn Glu Leu Leu Lys His Trp 
                805                 810                 815     


Trp Thr Ala Arg Glu Asp Ser Thr Gln Asp Phe Tyr Leu Ser Glu Arg 
            820                 825                 830         


Gln Tyr Asp Ile Tyr Asp Glu Lys Val Cys Phe Thr Ile Asn Ser Ser 
        835                 840                 845             


Ala His Phe Ala Asp Tyr Tyr Ala Pro Ala Leu Ser Lys Ala Tyr Ser 
    850                 855                 860                 


Arg Leu Arg Ala Glu Arg Asp Val Ala Arg Arg Thr Asp Lys Arg Leu 
865                 870                 875                 880 


Pro Pro Val Glu Arg Lys Asp Val Glu Arg Val Phe Lys Asn Thr Ile 
                885                 890                 895     


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
            900                 905                 910         


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asn Gln Gln Gln Leu Lys 
        915                 920                 925             


Leu Ser Lys Met Asp Ser Leu Leu Asn Glu Thr Lys Arg Ile Glu Gln 
    930                 935                 940                 


Val Ile Asn Thr Gln Leu Ser Phe Asp Gln Lys Gly Lys Glu Ile Lys 
945                 950                 955                 960 


Asp Lys Thr Asn Leu Glu Ile Val Lys Thr Ile Val Ala Glu Arg Lys 
                965                 970                 975     


Gln Lys Asn Tyr Thr Glu Met Arg Lys Tyr Val His Asp Arg Arg Leu 
            980                 985                 990         


Pro Glu Leu Phe Glu Tyr Ile Asp  Gly Asn Glu Leu Pro  Leu Asp Met 
        995                 1000                 1005             


Leu Leu  Asn Glu Leu Arg Ala  Tyr Asn Thr Ala Lys  Gln Val Val 
    1010                 1015                 1020             


Phe Asp  Thr Val Phe Ala Leu  Glu Lys Lys Ile Ile  Glu Thr Asp 
    1025                 1030                 1035             


Pro Glu  Gly Leu Lys Gln Leu  Asn Val Ser Lys Asp  Gly Gln Ile 
    1040                 1045                 1050             


Gln Thr  Gly Asn Ile Gln His  Lys Pro Tyr Val Gln  Trp Leu Glu 
    1055                 1060                 1065             


Asn Lys  Gly Leu Ile Thr Asp  Lys Asp Lys Gln Phe  Ile Asn Met 
    1070                 1075                 1080             


Val Arg  Asn Ser Phe Ser His  Asn Gln Phe Pro Gln  Arg Ser Thr 
    1085                 1090                 1095             


Val Glu  Leu Leu Met Pro Val  Trp Gln Asn Thr Asn  Ile Ala Leu 
    1100                 1105                 1110             


Gln Ile  Ala Arg Glu Tyr Gln  Gln Leu Ile Val Asp  Ile Ile Glu 
    1115                 1120                 1125             


Lys Ser  Leu His Pro His Lys  Gln His Gln Met Val  
    1130                 1135                 1140 


<210>  1515
<211>  1184
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1515

Met Glu Arg Ile Phe Gly His Cys Cys Pro His His Asp Ser Val Cys 
1               5                   10                  15      


Phe Val Arg Phe Leu Gly Thr Met Val Ser Asn Gln Asp Gly Arg Glu 
            20                  25                  30          


Asn Val Leu Asp Ile Leu Tyr Ile Ala Asp Arg Thr Arg Lys Leu Lys 
        35                  40                  45              


Pro Met Asn Thr Val Pro Ala Ser Glu Asn Lys Gly Gln Ser Arg Thr 
    50                  55                  60                  


Val Glu Asp Asp Pro Gln Tyr Phe Gly Leu Tyr Leu Asn Leu Ala Arg 
65                  70                  75                  80  


Glu Asn Leu Ile Glu Val Glu Ser His Val Arg Ile Lys Phe Gly Lys 
                85                  90                  95      


Lys Lys Leu Asn Glu Glu Ser Leu Lys Gln Ser Leu Leu Cys Asp His 
            100                 105                 110         


Leu Leu Ser Val Asp Arg Trp Thr Lys Val Tyr Gly His Ser Arg Arg 
        115                 120                 125             


Tyr Leu Pro Phe Leu His Tyr Phe Asp Pro Asp Ser Gln Ile Glu Lys 
    130                 135                 140                 


Asp His Asp Ser Lys Thr Gly Val Asp Pro Asp Ser Ala Gln Arg Leu 
145                 150                 155                 160 


Ile Arg Glu Leu Tyr Ser Leu Leu Asp Phe Leu Arg Asn Asp Phe Ser 
                165                 170                 175     


His Asn Arg Leu Asp Gly Thr Thr Phe Glu His Leu Glu Val Ser Pro 
            180                 185                 190         


Asp Ile Ser Ser Phe Ile Thr Gly Thr Tyr Ser Leu Ala Cys Gly Arg 
        195                 200                 205             


Ala Gln Ser Arg Phe Ala Val Phe Phe Lys Pro Asp Asp Phe Val Leu 
    210                 215                 220                 


Ala Lys Asn Arg Lys Glu Gln Leu Ile Ser Val Ala Asp Gly Lys Glu 
225                 230                 235                 240 


Cys Leu Thr Val Ser Gly Phe Ala Phe Phe Ile Cys Leu Phe Leu Asp 
                245                 250                 255     


Arg Glu Gln Ala Ser Gly Met Leu Ser Arg Ile Arg Gly Phe Lys Arg 
            260                 265                 270         


Thr Asp Glu Asn Trp Ala Arg Ala Val His Glu Thr Phe Cys Asp Leu 
        275                 280                 285             


Cys Ile Arg His Pro His Asp Arg Leu Glu Ser Ser Asn Thr Lys Glu 
    290                 295                 300                 


Ala Leu Leu Leu Asp Met Leu Asn Glu Leu Asn Arg Cys Pro Arg Ile 
305                 310                 315                 320 


Leu Tyr Asp Met Leu Pro Glu Glu Glu Arg Ala Gln Phe Leu Pro Ala 
                325                 330                 335     


Leu Asp Glu Asn Ser Met Asn Asn Leu Ser Glu Asn Ser Leu Asp Glu 
            340                 345                 350         


Glu Ser Arg Leu Leu Trp Asp Gly Ser Ser Asp Trp Ala Glu Ala Leu 
        355                 360                 365             


Thr Lys Arg Ile Arg His Gln Asp Arg Phe Pro Tyr Leu Met Leu Arg 
    370                 375                 380                 


Phe Ile Glu Glu Met Asp Leu Leu Lys Gly Ile Arg Phe Arg Val Asp 
385                 390                 395                 400 


Leu Gly Glu Ile Glu Leu Asp Ser Tyr Ser Lys Lys Val Gly Arg Asn 
                405                 410                 415     


Gly Glu Tyr Asp Arg Thr Ile Thr Asp His Ala Leu Ala Phe Gly Lys 
            420                 425                 430         


Leu Ser Asp Phe Gln Asn Glu Glu Glu Val Ser Arg Met Ile Ser Gly 
        435                 440                 445             


Glu Ala Ser Tyr Pro Val Arg Phe Ser Leu Phe Ala Pro Arg Tyr Ala 
    450                 455                 460                 


Ile Tyr Asp Asn Lys Ile Gly Tyr Cys His Thr Ser Asp Pro Val Tyr 
465                 470                 475                 480 


Pro Lys Ser Lys Thr Gly Glu Lys Arg Ala Leu Ser Asn Pro Gln Ser 
                485                 490                 495     


Met Gly Phe Ile Ser Val His Asp Leu Arg Lys Leu Leu Leu Met Glu 
            500                 505                 510         


Leu Leu Cys Glu Gly Ser Phe Ser Arg Met Gln Ser Asp Phe Leu Arg 
        515                 520                 525             


Lys Ala Asn Arg Ile Leu Asp Glu Thr Ala Glu Gly Lys Leu Gln Phe 
    530                 535                 540                 


Ser Ala Leu Phe Pro Glu Met Arg His Arg Phe Ile Pro Pro Gln Asn 
545                 550                 555                 560 


Pro Lys Ser Lys Asp Arg Arg Glu Lys Ala Glu Thr Thr Leu Glu Lys 
                565                 570                 575     


Tyr Lys Gln Glu Ile Lys Gly Arg Lys Asp Lys Leu Asn Ser Gln Leu 
            580                 585                 590         


Leu Ser Ala Phe Asp Met Asp Gln Arg Gln Leu Pro Ser Arg Leu Leu 
        595                 600                 605             


Asp Glu Trp Met Asn Ile Arg Pro Ala Ser His Ser Val Lys Leu Arg 
    610                 615                 620                 


Thr Tyr Val Lys Gln Leu Asn Glu Asp Cys Arg Leu Arg Leu Arg Lys 
625                 630                 635                 640 


Phe Arg Lys Asp Gly Asp Gly Lys Ala Arg Ala Ile Pro Leu Val Gly 
                645                 650                 655     


Glu Met Ala Thr Phe Leu Ser Gln Asp Ile Val Arg Met Ile Ile Ser 
            660                 665                 670         


Glu Glu Thr Lys Lys Leu Ile Thr Ser Ala Tyr Tyr Asn Glu Met Gln 
        675                 680                 685             


Arg Ser Leu Ala Gln Tyr Ala Gly Glu Glu Asn Arg Arg Gln Phe Arg 
    690                 695                 700                 


Ala Ile Val Ala Glu Leu Arg Leu Leu Asp Pro Ser Ser Gly His Pro 
705                 710                 715                 720 


Phe Leu Ser Ala Thr Met Glu Thr Ala His Arg Tyr Thr Glu Gly Phe 
                725                 730                 735     


Tyr Lys Cys Tyr Leu Glu Lys Lys Arg Glu Trp Leu Ala Lys Ile Phe 
            740                 745                 750         


Tyr Arg Pro Glu Gln Asp Glu Asn Thr Lys Arg Arg Ile Ser Val Phe 
        755                 760                 765             


Phe Val Pro Asp Gly Glu Ala Arg Lys Leu Leu Pro Leu Leu Ile Arg 
    770                 775                 780                 


Arg Arg Met Lys Glu Gln Asn Asp Leu Gln Asp Trp Ile Arg Asn Lys 
785                 790                 795                 800 


Gln Ala His Pro Ile Asp Leu Pro Ser His Leu Phe Asp Ser Lys Val 
                805                 810                 815     


Met Glu Leu Leu Lys Val Lys Asp Gly Lys Lys Lys Trp Asn Glu Ala 
            820                 825                 830         


Phe Lys Asp Trp Trp Ser Thr Lys Tyr Pro Asp Gly Met Gln Pro Phe 
        835                 840                 845             


Tyr Gly Leu Arg Arg Glu Leu Asn Ile His Gly Lys Ser Val Ser Tyr 
    850                 855                 860                 


Ile Pro Ser Asp Gly Lys Lys Phe Ala Asp Cys Tyr Thr His Leu Met 
865                 870                 875                 880 


Glu Lys Thr Val Arg Asp Lys Lys Arg Glu Leu Arg Thr Ala Gly Lys 
                885                 890                 895     


Pro Val Pro Pro Asp Leu Ala Ala Asp Ile Lys Arg Ser Phe His Arg 
            900                 905                 910         


Ala Val Asn Glu Arg Glu Phe Met Leu Arg Leu Val Gln Glu Asp Asp 
        915                 920                 925             


Arg Leu Met Leu Met Ala Ile Asn Lys Met Met Thr Asp Arg Glu Glu 
    930                 935                 940                 


Asp Ile Leu Pro Gly Leu Lys Asn Ile Asp Ser Ile Leu Asp Glu Glu 
945                 950                 955                 960 


Asn Gln Phe Ser Leu Ala Val His Ala Lys Val Leu Glu Lys Glu Gly 
                965                 970                 975     


Glu Gly Gly Asp Asn Ser Leu Ser Leu Val Pro Ala Thr Ile Glu Ile 
            980                 985                 990         


Lys Ser Lys Arg Lys Asp Trp Ser  Lys Tyr Ile Arg Tyr  Arg Tyr Asp 
        995                 1000                 1005             


Arg Arg  Val Pro Gly Leu Met  Ser His Phe Pro Glu  His Lys Ala 
    1010                 1015                 1020             


Thr Leu  Asp Glu Val Lys Thr  Leu Leu Gly Glu Tyr  Asp Arg Cys 
    1025                 1030                 1035             


Arg Ile  Lys Ile Phe Asp Trp  Ala Phe Ala Leu Glu  Gly Ala Ile 
    1040                 1045                 1050             


Met Ser  Asp Arg Asp Leu Lys  Pro Tyr Leu His Glu  Ser Ser Ser 
    1055                 1060                 1065             


Arg Glu  Gly Lys Ser Gly Glu  His Ser Thr Leu Val  Lys Met Leu 
    1070                 1075                 1080             


Val Glu  Lys Lys Gly Cys Leu  Thr Pro Asp Glu Ser  Gln Tyr Leu 
    1085                 1090                 1095             


Ile Leu  Ile Arg Asn Lys Ala  Ala His Asn Gln Phe  Pro Cys Ala 
    1100                 1105                 1110             


Ala Glu  Met Pro Leu Ile Tyr  Arg Asp Val Ser Ala  Lys Val Gly 
    1115                 1120                 1125             


Ser Ile  Glu Gly Ser Ser Ala  Lys Asp Leu Pro Glu  Gly Ser Ser 
    1130                 1135                 1140             


Leu Val  Asp Ser Leu Trp Lys  Lys Tyr Glu Met Ile  Ile Arg Lys 
    1145                 1150                 1155             


Ile Leu  Pro Ile Leu Asp Pro  Glu Asn Arg Phe Phe  Gly Lys Leu 
    1160                 1165                 1170             


Leu Asn  Asn Met Ser Gln Pro  Ile Asn Asp Leu 
    1175                 1180                 


<210>  1516
<211>  1090
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1516

Met Asn Ile Pro Ala Leu Val Glu Asn Gln Lys Lys Tyr Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Val Met Ala Met Leu Asn Ala Gln Thr Val Leu Asp His Ile 
            20                  25                  30          


Gln Lys Val Ala Asp Ile Glu Gly Glu Gln Asn Glu Asn Asn Glu Asp 
        35                  40                  45              


Leu Trp Thr His Pro Val Met Glu His Leu Lys Asp Ala Lys Asn Gly 
    50                  55                  60                  


Tyr Asp Lys Gln Pro Glu Lys Thr Met Phe Ile Ile Glu Arg Leu Gln 
65                  70                  75                  80  


Ser Tyr Phe Pro Phe Leu Lys Ile Met Ala Glu Asn Gln Arg Lys His 
                85                  90                  95      


Ser Asn Gly Lys Tyr Lys Gln Asn Arg Val Glu Val Asn Ser Asn Asp 
            100                 105                 110         


Ile Tyr Asn Val Leu Asn Lys Ile Ile Arg Val Leu Lys Met Tyr Arg 
        115                 120                 125             


Asp Leu Thr Asn His Tyr Lys Thr Tyr Asp Lys Lys Leu Val Asp Gly 
    130                 135                 140                 


Pro Gly Phe Leu Thr Gly Thr Glu Gln Pro Leu Ser Gly Met Ile Ser 
145                 150                 155                 160 


Lys Tyr Tyr Thr Val Ala Leu Arg Asn Thr Lys Glu Arg Tyr Gly Tyr 
                165                 170                 175     


Lys Ser Glu Asp Leu Ala Phe Ile Gln Asp Asn Ile Tyr Lys Phe Thr 
            180                 185                 190         


Lys Asp Ala Tyr Gly Lys Arg Lys Ser Gln Val Asn Thr Gly Phe Phe 
        195                 200                 205             


Leu Ser Leu Gln Asp Tyr Asn Gly Asp Thr Thr Glu Lys Leu His Leu 
    210                 215                 220                 


Ser Gly Val Gly Ile Ala Leu Leu Ile Cys Leu Phe Leu Asp Lys Gln 
225                 230                 235                 240 


Tyr Ile Asn Ile Phe Leu Ser Lys Leu Pro Ile Phe Ser Ser Tyr Asn 
                245                 250                 255     


Ala Gln Ser Glu Glu Arg Arg Ile Ile Ile Arg Ser Phe Gly Ile Asn 
            260                 265                 270         


Ser Ile Lys Gln Pro Lys Asp Arg Ile His Ser Glu Lys Ser Asn Lys 
        275                 280                 285             


Ser Val Ala Met Asp Met Leu Asn Glu Val Lys Arg Cys Pro Asp Asp 
    290                 295                 300                 


Leu Phe Thr Thr Leu Ser Ala Glu Lys Gln Ser Arg Phe Arg Ile Ile 
305                 310                 315                 320 


Ser Asp Asp His Asn Glu Val Leu Met Lys Arg Ser Thr Asp Arg Phe 
                325                 330                 335     


Val Pro Leu Leu Leu Gln Tyr Ile Asp Tyr Gly Lys Leu Phe Asp His 
            340                 345                 350         


Ile Arg Phe His Val Asn Met Gly Lys Leu Arg Tyr Leu Leu Lys Ala 
        355                 360                 365             


Asp Lys Thr Cys Ile Asp Gly Gln Thr Arg Val Arg Val Ile Glu Gln 
    370                 375                 380                 


Pro Leu Asn Gly Phe Gly Arg Leu Glu Glu Ala Glu Thr Met Arg Lys 
385                 390                 395                 400 


Gln Glu Asn Gly Thr Phe Gly Asn Ser Gly Ile Arg Ile Arg Asp Phe 
                405                 410                 415     


Glu Asn Met Lys Arg Asp Asp Ala Asn Pro Ala Asn Tyr Pro Tyr Ile 
            420                 425                 430         


Val Asp Thr Tyr Thr His Tyr Ile Leu Glu Asn Asn Lys Val Glu Met 
        435                 440                 445             


Phe Ile Ser Gly Glu Glu Asn Ser Ala Pro Leu Leu Pro Val Ile Glu 
    450                 455                 460                 


Asp Asp Arg Tyr Val Val Lys Thr Ile Pro Ser Cys Arg Met Ser Ser 
465                 470                 475                 480 


Leu Glu Ile Pro Ala Met Ala Phe His Leu Phe Leu Phe Gly Ser Glu 
                485                 490                 495     


Lys Thr Glu Lys Leu Ile Val Asp Val His Asn Arg Tyr Lys Arg Leu 
            500                 505                 510         


Phe Lys Ala Met Gln Lys Glu Glu Val Thr Val Gln Asn Ile Ala Ser 
        515                 520                 525             


Phe Gly Ile Ala Glu Ser Asp Leu Pro Gln Lys Ile Ile Asp Leu Ile 
    530                 535                 540                 


Ser Gly Asn Ala His Gly Lys Asp Val Glu Ala Phe Ile Arg Leu Thr 
545                 550                 555                 560 


Val Asp Asp Met Leu Ala Asp Thr Glu Arg Arg Ile Lys Arg Phe Lys 
                565                 570                 575     


Asp Asp Arg Lys Ser Ile Arg Ser Ala Asp Asn Lys Met Gly Lys Arg 
            580                 585                 590         


Gly Phe Lys Gln Ile Ser Thr Gly Lys Leu Ala Asp Phe Leu Ala Lys 
        595                 600                 605             


Asp Ile Val Leu Phe Gln Pro Ser Val Asn Asp Gly Glu Asn Lys Ile 
    610                 615                 620                 


Thr Gly Leu Asn Tyr Arg Ile Met Gln Ser Ala Ile Ala Val Tyr Asp 
625                 630                 635                 640 


Ser Gly Asp Asp Tyr Glu Ala Lys Gln Gln Phe Lys Leu Met Phe Glu 
                645                 650                 655     


Lys Ala Arg Leu Ile Gly Lys Gly Thr Thr Glu Pro His Pro Phe Leu 
            660                 665                 670         


Tyr Lys Val Phe Ala Arg Ser Ile Pro Ala Asn Ala Val Glu Phe Tyr 
        675                 680                 685             


Glu Arg Tyr Leu Ile Glu Arg Lys Phe Tyr Leu Thr Gly Leu Cys Asn 
    690                 695                 700                 


Glu Ile Lys Lys Gly Asn Arg Val Asp Val Pro Phe Ile Arg Arg Asp 
705                 710                 715                 720 


Gln Asn Lys Trp Lys Thr Pro Ala Met Lys Thr Leu Gly Arg Ile Tyr 
                725                 730                 735     


Ser Glu Asp Leu Pro Val Glu Leu Pro Arg Gln Met Phe Asp Asn Glu 
            740                 745                 750         


Ile Lys Ser His Leu Lys Ser Leu Pro Gln Met Glu Gly Ile Asp Phe 
        755                 760                 765             


Asn Asn Ala Asn Ile Thr Tyr Leu Ile Ala Glu Tyr Met Lys Arg Val 
    770                 775                 780                 


Leu Asp Asp Asp Phe Gln Thr Phe Tyr Gln Trp Asn Arg Asn Tyr His 
785                 790                 795                 800 


Tyr Met Asp Met Leu Lys Gly Glu Tyr Asp Arg Lys Gly Ser Leu Gln 
                805                 810                 815     


Asn Cys Phe Thr Ser Val Glu Glu Arg Glu Cys Leu Trp Lys Glu Arg 
            820                 825                 830         


Val Pro Arg Thr Glu Gln Tyr Arg Arg Leu Ala Ser Asn Lys Ile Lys 
        835                 840                 845             


Ser Asn Arg Gln Met Arg Asn Ala Ser Ser Glu Glu Ile Glu Thr Ile 
    850                 855                 860                 


Leu Asp Lys Arg Leu Ser Asn Ser Arg Asn Glu Tyr Gln Lys Ser Glu 
865                 870                 875                 880 


Lys Val Ile Arg Arg Tyr Arg Val Gln Asp Ala Leu Leu Phe Leu Leu 
                885                 890                 895     


Ala Lys Lys Thr Leu Thr Val Leu Ala Asp Phe Asp Gly Glu Arg Phe 
            900                 905                 910         


Lys Leu Lys Glu Ile Met Pro Asp Ala Glu Lys Gly Ile Leu Ser Glu 
        915                 920                 925             


Ile Met Pro Met Ser Phe Thr Phe Glu Lys Gly Gly Lys Lys Tyr Thr 
    930                 935                 940                 


Ile Thr Ser Glu Gly Met Lys Leu Lys Asn Tyr Gly Asp Phe Phe Val 
945                 950                 955                 960 


Leu Ala Ser Asp Lys Arg Ile Gly Asn Leu Leu Glu Leu Val Gly Ser 
                965                 970                 975     


Asp Thr Val Ser Lys Glu Asp Ile Met Glu Glu Phe Lys Lys Tyr Asp 
            980                 985                 990         


Gln Cys Arg Pro Glu Ile Ser Ser  Ile Val Phe Asn Leu  Glu Lys Trp 
        995                 1000                 1005             


Ala Phe  Asp Thr Tyr Pro Glu  Leu Pro Ala Arg Val  Asp Arg Lys 
    1010                 1015                 1020             


Glu Lys  Val Asp Phe Trp Ser  Ile Leu Asp Val Leu  Ser Asn Asn 
    1025                 1030                 1035             


Lys Asp  Ile Asn Asn Glu Gln  Ser Tyr Ile Leu Arg  Lys Ile Arg 
    1040                 1045                 1050             


Asn Ala  Phe Asp His Asn Asn  Tyr Pro Asp Lys Gly  Ile Val Glu 
    1055                 1060                 1065             


Ile Lys  Ala Leu Pro Glu Ile  Ala Met Ser Ile Lys  Lys Ala Phe 
    1070                 1075                 1080             


Gly Glu  Tyr Ala Ile Met Lys  
    1085                 1090 


<210>  1517
<211>  1101
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1517

Val Arg Glu Ser Tyr Leu Val Phe Tyr His Leu His Tyr Thr Phe Ser 
1               5                   10                  15      


Ile Lys Ile Leu Phe Thr Met Glu Lys Tyr Lys Ile Val Asn Leu Lys 
            20                  25                  30          


Pro Thr Met Ala Leu Tyr Ala Asn Ile Ala Leu Asn Thr Ile Glu Lys 
        35                  40                  45              


Leu Cys Asp Asn Gln Thr Asp Ser Ile Ser Thr Ser Lys Lys Glu Leu 
    50                  55                  60                  


Ala Glu Glu Val Lys Gly Trp Asn Thr Glu Arg Gln Ile Thr Val Ala 
65                  70                  75                  80  


Arg Lys Leu Tyr Thr Asn Phe Tyr Phe Ile Glu Arg Leu Phe Ser Asp 
                85                  90                  95      


Thr Glu Phe Lys Ala Asn Lys Asn Gln Thr Asp Arg Val Asn Glu Glu 
            100                 105                 110         


Gln Ser Ile Gln Thr Leu Gln Ala Lys Glu Val Ile Thr Trp Leu Asn 
        115                 120                 125             


Leu Leu Phe Asp Ile Arg Cys Tyr Cys Thr His Asn Ile His Ser Glu 
    130                 135                 140                 


Pro Leu Val Ser Asn Tyr His Glu Ser Ser Val Lys Ser Leu Leu Glu 
145                 150                 155                 160 


Asn Leu Tyr Gln Glu Ala Val Asn His Ser Lys Thr Ser Val Pro Asp 
                165                 170                 175     


Lys Phe Arg Asp Ala Cys Ser Leu Phe Glu Thr Cys Thr Lys Glu Ser 
            180                 185                 190         


Lys Tyr Glu Arg Thr Thr Lys His Arg Asp Lys Tyr Arg Gln Ile Asn 
        195                 200                 205             


Asn Thr Tyr Phe Ser Phe Thr Ala Gln Val Phe Ile Ile Cys Leu Phe 
    210                 215                 220                 


Leu Asp Arg Asp Ser Val Asn Glu Phe Leu Glu Ala Ile Glu Ile Ala 
225                 230                 235                 240 


His Leu Pro Asp Gly Ser Glu Glu Ala Arg Thr Asn Phe Arg Leu Leu 
                245                 250                 255     


Asn Pro Gly Glu Pro Tyr Pro Glu Glu Leu Arg Ala Pro Tyr Lys Gln 
            260                 265                 270         


Val Leu Tyr Ala Arg Asp Ile Tyr Thr Tyr Trp Ala Ala Arg Gly His 
        275                 280                 285             


Arg Ser His Leu Ser Leu Ala Ala Asp Ser Val Leu Lys Glu Lys Tyr 
    290                 295                 300                 


Phe Ser Ile Leu Glu His Leu Lys Arg Ile Pro Gln Glu Arg Leu Glu 
305                 310                 315                 320 


Gly Asp Glu Arg Val Tyr Ser Phe Asp Ile Arg Glu Lys Asn Lys Phe 
                325                 330                 335     


Met Glu Trp Ala Leu Glu Phe Trp Glu Thr Glu Tyr Lys Ala Cys Gly 
            340                 345                 350         


Ala Gly Gly Lys Glu Ile Asn Trp Lys Trp Ala Arg His Ala Ser Val 
        355                 360                 365             


Glu Asp Lys Lys Ala Val Lys Gln Lys Thr Ala Glu Arg Gln Gln Gln 
    370                 375                 380                 


Pro Gly Lys Val Ser Glu Arg Ile Gln Pro Leu Arg Arg His Glu Lys 
385                 390                 395                 400 


Val Val Trp Gln Ile Pro Asp Asp Glu Asn Ser Arg Leu Asn Asp Arg 
                405                 410                 415     


Gly Asp Glu Ser Gly Phe Pro Tyr Tyr Phe Glu Lys Asp Asp Lys Gly 
            420                 425                 430         


Glu Tyr Ser Gln Ala Leu Phe Gln Cys Ile Gln Gly Lys Gly Glu Gly 
        435                 440                 445             


Arg Arg Ile Ile Ile Gly Leu Met Ser Arg Lys Thr Leu Cys Ser Ile 
    450                 455                 460                 


Leu Glu Ala Tyr Leu Thr Leu Phe Pro Leu Asp Asp Lys Val Glu Ile 
465                 470                 475                 480 


Asn Phe Pro Asp Arg Lys Lys Asp Phe Phe Val Glu Ile Thr Lys Ala 
                485                 490                 495     


Cys Ile Asn Tyr Val Ala Asn Lys Tyr Pro Glu Leu Thr Gly Arg Lys 
            500                 505                 510         


Glu Lys His Ile Val Thr Arg Pro Glu Ile Glu Asn Arg Ile Ala Tyr 
        515                 520                 525             


Leu Gln Gln Lys Tyr Lys Gln Gln Glu Glu Glu Thr Asn Leu His Lys 
    530                 535                 540                 


Arg Ile Ile Thr Ile Ala Asp Thr Trp Asn Gln Met Ile Thr Cys Ala 
545                 550                 555                 560 


Ala Arg Thr Asn Pro Thr His Ala Leu Asp Asp Lys Gly Val Thr Gly 
                565                 570                 575     


Gly Lys Asn Gly Tyr Gln Glu Ile Ile Lys Tyr Leu Ser Phe Met Ser 
            580                 585                 590         


Pro Ala Pro Ile Thr Tyr Ile Gln Arg Glu Asp Glu Glu Asp Asn Ser 
        595                 600                 605             


Tyr Arg Ser Arg Glu Tyr Lys Lys Thr Gln Lys Ile Arg Glu Glu Lys 
    610                 615                 620                 


Ala Ser Asp Leu Ile Thr Leu Leu Lys Gln Leu Gly Gly Thr Lys Thr 
625                 630                 635                 640 


Lys Asn Asn Tyr Tyr Gln Gln Ile Asn Asn Ser Leu Asn His Gly Ile 
                645                 650                 655     


Asp Lys Arg Leu Ser Asn Thr Leu Asn Lys Lys Asp Val Ala Ser Cys 
            660                 665                 670         


His Thr Ile Ala Glu Leu Phe Arg Gln Cys Met Glu Tyr Arg Met Cys 
        675                 680                 685             


Thr Leu Lys Val Tyr Ser Asp Lys Leu Lys Ser Gly Leu Phe Asn Pro 
    690                 695                 700                 


Glu Leu Trp Lys Pro Asn Thr Glu Met Arg Trp Leu Gly Leu Arg Asp 
705                 710                 715                 720 


Thr Arg Thr Pro Gln Ala Ala Gln Asn Glu Glu Gln Pro Pro Lys Pro 
                725                 730                 735     


Leu Gln Thr Gly Ile Leu Asn Val Asp Arg His Gln His Thr Ala Val 
            740                 745                 750         


Gly Met Pro Ser Glu Leu Arg Glu Leu Ile Ser Lys Glu Leu Phe Thr 
        755                 760                 765             


Lys Trp Phe Gly Glu Ala Lys Gln Pro Leu His Gln Gly Leu Tyr Pro 
    770                 775                 780                 


Ser Pro Gly Asn Asn Val Leu Leu Ile Pro Asp Phe Tyr Ala Leu Gln 
785                 790                 795                 800 


Asn His Ser Val Trp Glu Ser Met Ser Gly Pro Gln Lys Lys Arg Leu 
                805                 810                 815     


Tyr Gln Ile Arg Arg Glu Asp Thr Leu Leu Ser His Phe Ala Tyr Tyr 
            820                 825                 830         


Tyr Ala Leu Lys Ala Gly Leu Pro Pro His Asn Met Glu Leu Ile Gly 
        835                 840                 845             


Lys Asp Phe Gln Asp Leu Ser Leu Gln Met Pro Ile Ala His Pro Glu 
    850                 855                 860                 


Asn Gly Ile Leu Leu Ala Asn Ile Ser Phe Tyr Tyr Arg His Tyr Lys 
865                 870                 875                 880 


Gln Asn Arg Tyr Arg Leu Pro Ala Lys Leu Thr Val Gly Leu Ile Asn 
                885                 890                 895     


Leu Leu Val Glu Arg Gly Leu Ile Glu Cys Gly Ser Glu Ile Pro His 
            900                 905                 910         


Asn Thr Leu Val Leu Arg Pro Lys Asn Glu Leu Thr Asp Glu Asp Lys 
        915                 920                 925             


Leu Thr His Phe Gly Glu Arg Ala Tyr Glu Thr Leu Ser Lys Glu Glu 
    930                 935                 940                 


Gln Ile Ser Lys Ile Asn Glu Lys Leu Ser Val Met Ser Ser Asp Asn 
945                 950                 955                 960 


Val Phe Ile Pro Val Lys Gly Glu Arg Lys Tyr Phe Ile Thr Glu Leu 
                965                 970                 975     


Leu Asn Ser Tyr Thr Ile Cys Arg Lys Val Phe Ile Asn Arg Ile Phe 
            980                 985                 990         


His Leu Glu Asn Val Val Ile Asn  Lys Tyr Ser Leu Gln  Lys Lys Asn 
        995                 1000                 1005             


Asp Lys  Asn Tyr Leu Ser Phe  Lys Glu Leu Ser Glu  Thr Leu Arg 
    1010                 1015                 1020             


Thr Tyr  Asn Ile Leu Asn Asp  Asp Glu Val Ala Lys  Leu Val Gln 
    1025                 1030                 1035             


Leu Arg  Asn Ala Ala Phe His  Thr Asp Val Pro Ser  Ala Asp Leu 
    1040                 1045                 1050             


Leu Ile  Pro Asp Asn Glu Lys  Leu Ile Lys Leu Thr  Lys Thr His 
    1055                 1060                 1065             


Pro Thr  Lys Glu Tyr Ile Asp  Ile Phe Gly Thr Gly  Phe Asp Leu 
    1070                 1075                 1080             


Ile Asn  Lys Cys Leu Asp Ser  Leu Glu Lys Asp Lys  Val Lys Lys 
    1085                 1090                 1095             


Tyr Lys  His 
    1100     


<210>  1518
<211>  1129
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1518

Met Glu Thr Asn Gln Gln Thr His Glu Asn Arg Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Asn Asn His Val Ala Thr Asp Phe Lys Arg Lys Pro 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Asp Ala Leu Leu Cys Asn Lys Thr 
    50                  55                  60                  


Ile Lys Asn Leu Asn Trp Asn His Val His Thr Arg Ala Leu Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ser Glu Ser Leu Pro Lys Asp Glu 
                85                  90                  95      


Arg Lys Asn Ser Asp Thr Glu Gly Lys Asp Phe Thr Ser Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Ser Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Asp Ser Arg Lys Leu Ile Val 
    130                 135                 140                 


Ser Pro Glu Leu Ala Asn Phe Leu Thr Ile Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Thr Tyr Thr Lys Ala Arg Met Lys Asp Val Leu Thr Asp Ala Asp Tyr 
                165                 170                 175     


Ala Leu Val Glu Asn Leu Gln Met Val Ala Thr Asp Asn Lys Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ala Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asn Gln Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Ser 
            260                 265                 270         


Ile Ile Thr Asp Lys Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Glu Asn Leu Ile Ala Asn Ser Thr Asn Asn Glu Glu Arg 
    290                 295                 300                 


Glu Arg Ile Leu Asp Glu Ile Asp Tyr Gln Asp Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg Tyr Asn Asn Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Asp Glu Lys Asn Ile Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Asn Tyr Thr Lys Gln Phe Ala Gly Glu 
        355                 360                 365             


Gln Ala Glu Arg Lys Val Leu Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asp Pro Glu Leu Ser Gln Gln Arg Ile Asp Lys Gln 
385                 390                 395                 400 


Gln Gln Thr Ala Gly Phe Glu Gln Phe Ala Pro Arg Tyr His Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Asn Ile Ala Thr Leu Thr 
            420                 425                 430         


Ala Lys Ser Lys Ala Gly Ser Lys Val Glu His Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Gln Ala Glu Glu Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Ile Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Ser Gln Leu Pro Asp Gly Trp Asn Glu Phe Asn Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asp Ser Thr Leu Arg Tyr Leu 
        515                 520                 525             


His Gln Arg Lys Thr Ile Leu Asn Thr Ile Leu Ser Lys Tyr Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Lys Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Thr Arg Leu Lys Ala Val Glu Lys His Lys Leu 
            580                 585                 590         


Asn Lys Ser Val Lys Ile Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Glu Glu Lys Lys Lys Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Thr Asn Ala Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Asn Asp Gly His Pro Phe Leu Gln Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Gln Ala Tyr Leu Ile 
        675                 680                 685             


Glu Lys Gly Asn Lys Met Val Pro Arg Leu Asn Pro Lys Thr Asn Lys 
    690                 695                 700                 


Thr Ser Lys Val Asp Glu Ser Trp Met Met Lys Gln Phe Tyr Val Lys 
705                 710                 715                 720 


Glu Trp Lys Glu Glu Ile Ala Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Ser Arg Ile Pro Phe Thr Ile Arg Gln Trp Asp Glu Lys 
            740                 745                 750         


Glu Lys Tyr Asp Leu Asn Thr Trp Leu Arg His Val Thr Val Gly Lys 
        755                 760                 765             


Asn Asn Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe Asp 
    770                 775                 780                 


Glu Ala Leu Cys Asp Leu Leu Arg Glu Gln Leu Asp Thr Lys Ile Val 
785                 790                 795                 800 


Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Ile Trp Trp 
                805                 810                 815     


Lys Thr Arg Asn Asp Asp Thr Gln Gln Phe Tyr Gln Ser Glu Arg Glu 
            820                 825                 830         


Tyr Asn Ile Tyr Asn Glu Lys Val Arg Phe Lys Ile Asp Ser Ser Ala 
        835                 840                 845             


His Phe Ala Asp Tyr Tyr Lys Asn Ala Leu Ser Arg Ala Phe Thr Arg 
    850                 855                 860                 


Leu Lys Ala Glu Arg Glu Thr Ala Arg Gln Ser Asn Lys Arg Leu Pro 
865                 870                 875                 880 


Pro Leu Glu Tyr Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile Ala 
                885                 890                 895     


Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met Ala 
            900                 905                 910         


Val Leu Met Leu Glu Arg Leu Met Asp Asn Ser Pro Asn Leu Arg Leu 
        915                 920                 925             


Ser Lys Ile Glu Thr Leu Leu Asn Asp Thr Thr Pro Ile Arg Glu Lys 
    930                 935                 940                 


Ile Ser Ala Thr Leu Ser Phe Asp Ala Ser Gly Glu Arg Ile Ser Gly 
945                 950                 955                 960 


Lys Ser Asn Pro Thr Val Thr Lys Thr Leu Val Ala Glu Arg Lys Gln 
                965                 970                 975     


Lys Asn Tyr Thr Glu Leu Arg Lys Tyr Arg Tyr Asp Arg Arg Leu Pro 
            980                 985                 990         


Glu Leu Phe Glu Tyr Val Gln Ala  Asp Glu Ile Pro Leu  Glu Trp Leu 
        995                 1000                 1005             


Leu Glu  Glu Leu Ser Ala Tyr  Asn Asn Ala Lys Gln  Gln Val Phe 
    1010                 1015                 1020             


Asp Thr  Val Phe Thr Leu Glu  Lys Lys Ile Ile Gly  Thr Asp Pro 
    1025                 1030                 1035             


Asp Gly  Leu Lys Ser Leu Phe  Thr Gly Ala Asn Gly  Glu Leu Gln 
    1040                 1045                 1050             


Thr Gly  Asn Ile Gln His Lys  Pro Tyr Val Gln Trp  Leu Thr Asn 
    1055                 1060                 1065             


Lys Gly  Leu Ile Asn Lys Glu  Glu Lys Gln Phe Ile  Asn Met Val 
    1070                 1075                 1080             


Arg Lys  Cys Phe Ser His Asn  Gln Phe Pro Gln Arg  Lys Thr Met 
    1085                 1090                 1095             


Glu Leu  Leu Ile Pro Ala Trp  Asn Glu Lys Lys Leu  Ala Leu Gln 
    1100                 1105                 1110             


Ile Ala  Thr Val Tyr Asn Gln  Leu Ile Ala Asp Leu  Thr Asn Lys 
    1115                 1120                 1125             


Ile 
    


<210>  1519
<211>  1183
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1519

Met Pro Glu Thr Cys Arg Asn Phe Ile Ile Asn Cys Thr Glu Ile Ser 
1               5                   10                  15      


Gly Lys Leu His Arg Thr Val Leu Ile Ser Ser Arg Lys Phe His Gln 
            20                  25                  30          


Arg Arg Lys Glu Lys Lys Met Arg His Gln Gln Asn Ala Gln Tyr Gly 
        35                  40                  45              


Ala Cys Gln Trp Arg Asp Arg Ala Ser Ala Lys Lys Arg Thr Tyr Leu 
    50                  55                  60                  


Ser Gly Asp Tyr Lys Lys Asp Met Ala Met Leu Arg Ile Phe Gly Asn 
65                  70                  75                  80  


Ile Arg Asn Pro Gln Thr Arg Lys Asp Glu Phe Lys Asn Glu Val Pro 
                85                  90                  95      


Gln Phe Ile Thr Tyr Leu Thr Leu Ala Leu Gln Asn Val Ser Glu Ile 
            100                 105                 110         


Ile Gly Thr Asp Leu Ser Asn Leu Arg Asp Glu Ser Ser Val Lys Thr 
        115                 120                 125             


Ala Leu Glu Glu Asn Gly Arg Leu Phe Glu Val Ala Ser Phe Leu Trp 
    130                 135                 140                 


Met Tyr Arg Val Glu Glu Pro Gly Arg Asp Tyr Asp Arg Ile Lys Lys 
145                 150                 155                 160 


Gly Glu Tyr Ala Asp Arg Ala Lys Glu Ile Val Val Ala Leu Trp Lys 
                165                 170                 175     


Leu Arg Asn Met Phe Val His Pro Tyr Glu Arg Asn Ala Ala Arg Ala 
            180                 185                 190         


Leu Ile Val Ser Pro Glu Phe Tyr Arg Phe Ile Glu Gly Glu Leu Tyr 
        195                 200                 205             


Ser Glu Ala Arg Glu His Ala Leu Gly Pro Gly Arg Lys Ser Glu Lys 
    210                 215                 220                 


Ile Phe Lys Leu Lys Leu Phe Asn Pro His Asp Asp Ala Arg Thr Thr 
225                 230                 235                 240 


Phe Glu Phe Thr Arg Lys Gly Leu Ile Phe Leu Thr Cys Leu Gly Leu 
                245                 250                 255     


Tyr Arg His Asp Ala Ser Glu Phe Ile Gln Gln Phe Pro Asp Leu Gln 
            260                 265                 270         


Leu Pro Pro Arg Glu Trp Gln Val Glu Gln Gly Tyr Arg Ala Lys Pro 
        275                 280                 285             


Ser Glu Ser Glu Leu Val Glu Leu Arg Lys Lys Gly Gly Ala Val Lys 
    290                 295                 300                 


Ser Ile Leu Asp Ala Phe Thr Trp Tyr Ser Met Arg Ala Ser Arg Met 
305                 310                 315                 320 


Asp Ile Asp Val Ala Asn Ser Asp Tyr Leu Asn Phe Ala Asn Ile Leu 
                325                 330                 335     


Val Tyr Leu Asn Lys Val Pro Ser Ala Ala Tyr Asn Tyr Leu Leu Leu 
            340                 345                 350         


Asp Asp Glu Ala Lys Arg Leu Thr Lys Arg Ala Ala Ala Ser Gln Glu 
        355                 360                 365             


Ser Glu Glu Asn Lys Arg Phe Lys Tyr Leu Leu Gln Glu Arg Lys Lys 
    370                 375                 380                 


Asp Arg Phe Leu Thr Leu Ala Leu Ala Tyr Leu Glu Asp Phe His Lys 
385                 390                 395                 400 


Leu Asp Cys Ile Arg Phe Lys Arg Leu Asp Ile Thr Val Arg Pro Asp 
                405                 410                 415     


Arg Lys Arg Tyr Met Phe Gly Pro Ile Pro Glu Gly Thr Val Asn Glu 
            420                 425                 430         


Arg Gly Glu Pro Leu Asn Asp Ala Asn Gly Met Asp Arg His Tyr Ala 
        435                 440                 445             


Ile Gln Asn Gly Ser Ala Gln Phe Glu Phe Val Pro Glu Gln His Tyr 
    450                 455                 460                 


Gly Pro Ile Gln Ile Lys Arg Leu Arg Gly Ala Val Ser Glu Gly Glu 
465                 470                 475                 480 


Ile Met Arg Leu Leu Leu Val Met Phe Asp Asn Gly Ile Arg Arg Lys 
                485                 490                 495     


Lys Pro Asn Asp Val Ile Lys Glu Tyr Leu Ile Ala Tyr His Arg Ile 
            500                 505                 510         


Leu Glu Arg Met Leu Asn Ala Gly Asp Thr Gly Ala Phe Thr Phe Asp 
        515                 520                 525             


Asp Pro Leu Phe Arg Ala Asp Phe Lys Thr Val Ser Gly Lys Gly Asp 
    530                 535                 540                 


Asp Val Phe Thr Lys Gly Arg Phe Val Gly Glu Met Lys Pro Phe Phe 
545                 550                 555                 560 


Ser Glu Asn Val Thr Arg Tyr Phe Val Gly Asp Glu Leu Arg Pro Thr 
                565                 570                 575     


Pro Glu Ala Leu Gln Lys Lys Leu Val Lys Arg Phe Glu Ala Met Gln 
            580                 585                 590         


Gly Arg Ala Glu Asp Phe Leu Leu Lys Met Asn Arg Leu Thr Asp Trp 
        595                 600                 605             


Arg Lys Leu Asp Leu Glu Ala Arg Lys Asp Lys Ala Phe Pro Val Cys 
    610                 615                 620                 


Ser Ile Gly Glu Leu Lys Tyr Pro Pro Arg Thr Cys Lys Val Asn Asp 
625                 630                 635                 640 


Ala Gln Leu Val Lys Trp Val Leu Arg Tyr Ile Asn Leu Phe Leu Ala 
                645                 650                 655     


Lys Glu Glu Lys Phe Arg Gln Leu Pro Arg Gly Leu Arg His Arg Gly 
            660                 665                 670         


Val Arg Asp Phe Glu Phe Gln Leu Leu His Thr Asp Ile Gly Arg Phe 
        675                 680                 685             


Gly Val Asn Pro Asp Ala Leu Trp Arg Thr Leu Glu Lys Arg Ser Ser 
    690                 695                 700                 


Ile Asn Gly Glu Asp Gly Ala Leu Lys Met Leu Glu Asp Arg Glu Gln 
705                 710                 715                 720 


Glu Leu Phe Arg Ser Glu Gln Asn Arg Cys Arg Gly Lys Arg Asp Arg 
                725                 730                 735     


Asn Gly Arg Pro Leu Arg Pro Gly His Thr Leu Thr Met Leu Ala Thr 
            740                 745                 750         


Ala Ala Ala Glu Leu Tyr Arg Glu Ser Ser Glu Ser Phe Arg Ser Glu 
        755                 760                 765             


Tyr Ser Val Pro Leu Ser Asp Glu Asp Lys Asp Leu Leu Pro Tyr Val 
    770                 775                 780                 


Cys Pro Thr Tyr Gly Val Arg Ala Gly Leu Pro Leu Asp Gln Lys Ser 
785                 790                 795                 800 


Leu Val Lys Thr Val Leu Gly Ile Asp Leu Asp Thr Trp Ser Arg Ala 
                805                 810                 815     


Tyr Asp Tyr Ala Thr Gly Arg Asn Phe Glu Asn Arg Arg Leu Ser Asn 
            820                 825                 830         


Ala His Asp Leu Ile Val Ser Gln Val Pro Met Pro Asn Ala Phe Ala 
        835                 840                 845             


Ile Arg Cys Val Lys Pro Gly Glu Asn Gly Glu Pro Phe Lys Phe Asn 
    850                 855                 860                 


Pro Glu Phe Arg Thr Phe Met Pro Tyr Glu Arg Gly Lys Met Ser Leu 
865                 870                 875                 880 


Arg Gly Tyr Tyr Asp Ala Thr Pro Leu Ile Val Ala Val Lys Arg Phe 
                885                 890                 895     


Asp Glu Gln Ser Ser Leu Gly Lys Gly Gly His Glu Arg Ala Asn Ala 
            900                 905                 910         


Glu Ile Arg Cys Ser Gly Thr Glu Gly Ile Glu Thr Arg Glu Trp Thr 
        915                 920                 925             


Asp Asp Gly Asp Ile Gly Ser Gly Lys Glu Pro Pro Arg Ser Arg Pro 
    930                 935                 940                 


Ser Phe Ala Arg Gly Asp Val Asn Lys Ala Ile Gln Ala Ile Gln Leu 
945                 950                 955                 960 


Ala Glu Arg Gln Asp Lys Val Leu Leu Ala Cys Ala Lys Ala Tyr Trp 
                965                 970                 975     


Asp Arg Tyr Met Gly Glu Glu Val Thr Ala Thr Gln Asn Glu Thr Gly 
            980                 985                 990         


Lys Lys Asp Gln Gln Lys Lys Asn  Lys Ile Lys Asn Phe  His Leu Ala 
        995                 1000                 1005             


Glu Ala  Ala Asp Ile Gly Glu  Phe Phe Ser Leu Pro  Ile Asp Asp 
    1010                 1015                 1020             


Thr Val  Asn Gly Val Lys Ile  Arg Met Met Pro Asn  Asp Phe Ala 
    1025                 1030                 1035             


Arg Pro  Ala Tyr Gly Val Val  Thr Thr His Val Lys  Glu Leu Val 
    1040                 1045                 1050             


Glu Gly  Val Lys Pro Leu Pro  Gly Thr Asp Ser Val  Tyr Ser Phe 
    1055                 1060                 1065             


Tyr Asp  Leu Trp Leu Glu Leu  Arg Asn Leu Gln His  Lys Glu Asn 
    1070                 1075                 1080             


Arg Val  Arg Leu Asp Phe Leu  Pro Ala Ala Val Lys  Phe Asn Ala 
    1085                 1090                 1095             


Trp Val  Asn Ile Pro Ala Asn  Leu Glu Ser Leu Pro  Asn Asp Asp 
    1100                 1105                 1110             


Pro Glu  Lys Thr Pro Arg Ile  Leu Ser His Cys Asn  Lys Ala Leu 
    1115                 1120                 1125             


Arg Leu  Leu Arg Leu Arg Gly  Asn Val Glu Pro Leu  Ser Glu Glu 
    1130                 1135                 1140             


Glu Tyr  Leu Leu Leu Ala Lys  Phe Glu Pro Arg Leu  Arg His Pro 
    1145                 1150                 1155             


Ala Arg  Lys Gly Leu Asp Leu  Val His Phe Asp Thr  Asp Ala Val 
    1160                 1165                 1170             


Arg Ala  Ile Tyr Lys Arg Phe  Gly Phe Leu 
    1175                 1180             


<210>  1520
<211>  1129
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1520

Met Glu Thr Asn Gln Gln Thr His Glu Asn Arg Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Asn Asn His Ile Ala Thr Asp Phe Lys Gln Ala Thr 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ala Ala Phe Leu Cys Asn Lys Thr 
    50                  55                  60                  


Ile Lys Asn Leu Asn Trp Asn His Val His Thr Arg Ala Val Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ser Glu Ser Leu Pro Lys Asp Glu 
                85                  90                  95      


Arg Glu Asn Ser Asp Thr Glu Gly Lys Asp Phe Thr Ser Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Ser Glu Leu Gln Asp Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Asp Ser Arg Lys Leu Ile Val 
    130                 135                 140                 


Ser Pro Glu Leu Ala Asn Phe Leu Thr Val Asn Phe Gln Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Ala Arg Met Lys Asp Val Leu Thr Asp Thr Asp Tyr 
                165                 170                 175     


Ala Leu Val Glu Asn Leu Gln Met Val Ala Pro Asp Asn Lys Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ala Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Thr Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asn Leu Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Ser 
            260                 265                 270         


Val Ile Thr Asp Lys Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Asp Asp Glu Cys 
    290                 295                 300                 


Glu Arg Ile Leu Asp Glu Ile Asp Tyr Gln Asp Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg Tyr Ser Asp Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Asp Glu Lys Asn Val Phe Asp Asn Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Asn Tyr Thr Lys Gln Phe Ala Gly Glu 
        355                 360                 365             


Gln Ala Glu Arg Lys Val Leu Glu Asn Ala Asn Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asp Pro Glu Leu Ile Gln Gln Arg Ile Asp Lys Gln 
385                 390                 395                 400 


Gln His Thr Ala Gly Phe Asp Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Asn Ile Ala Ile Leu Thr 
            420                 425                 430         


Ala Lys Ser Lys Ala Asp Ser Lys Val Glu His Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Gln Ala Glu Glu Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Ile Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Ser Gln Leu Pro Ala Asn Trp Asp Glu Phe Ser Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asp Ser Thr Leu Lys Tyr Leu 
        515                 520                 525             


Arg Gln Arg Lys Thr Thr Leu Asn Thr Ile Leu Ser Lys Ser Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Lys Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Thr Arg Leu Lys Ala Val Glu Lys His Lys Leu 
            580                 585                 590         


Asn Lys Ser Val Lys Ile Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Glu Glu Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Ala Asn Ala Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Phe Glu Asn Gly Gly His Pro Phe Leu Gln Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Gln Ala Tyr Leu Val 
        675                 680                 685             


Glu Lys Gly Asn Lys Met Val Pro Arg Leu Asn Pro Lys Thr Asn Lys 
    690                 695                 700                 


Thr Ser Lys Val Asp Glu Ser Trp Met Met Lys Gln Phe Tyr Val Lys 
705                 710                 715                 720 


Glu Trp Lys Glu Glu Ile Gly Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Ser Gln Ile Pro Phe Thr Ile Arg Gln Trp Asp Glu Lys 
            740                 745                 750         


Glu Lys Tyr Asp Leu Asn Thr Trp Leu Gln His Val Thr Val Gly Lys 
        755                 760                 765             


Asn Lys Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe Asp 
    770                 775                 780                 


Glu Ala Leu Cys Asp Leu Leu Arg Glu Gln Leu Asp Thr Lys Ile Val 
785                 790                 795                 800 


Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Ile Trp Trp 
                805                 810                 815     


Lys Thr Arg Asn Asp Asp Thr Gln Gln Phe Tyr Gln Ser Glu Arg Glu 
            820                 825                 830         


Tyr Asp Ile Tyr Asn Glu Lys Val Arg Phe Lys Ile Asp Ser Ser Ala 
        835                 840                 845             


His Phe Ala Asp Tyr Tyr Lys Asn Ala Leu Ser Arg Ala Phe Thr Arg 
    850                 855                 860                 


Leu Lys Ala Glu Arg Glu Thr Ala Arg Gln Thr Asn Lys Arg Leu Pro 
865                 870                 875                 880 


Pro Leu Glu Tyr Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile Ala 
                885                 890                 895     


Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met Ala 
            900                 905                 910         


Val Leu Met Leu Glu Gln Leu Met Asp Asn Ser Pro Asn Leu Arg Leu 
        915                 920                 925             


Ser Lys Ile Glu Thr Leu Leu Asn Asp Thr Thr Pro Ile Ser Glu Lys 
    930                 935                 940                 


Ile Ser Ala Lys Leu Ser Phe Asp Ala Ser Gly Glu Arg Ile Thr Asp 
945                 950                 955                 960 


Lys Ser Asn Pro Thr Val Thr Lys Thr Leu Val Ala Glu Arg Lys Gln 
                965                 970                 975     


Lys Asn Tyr Thr Glu Leu Gln Lys Tyr Arg Tyr Asp Arg Arg Leu Pro 
            980                 985                 990         


Glu Leu Phe Glu Tyr Val Gln Ala  Asp Glu Ile Pro Leu  Glu Trp Leu 
        995                 1000                 1005             


Leu Asp  Glu Leu Ser Ala Tyr  Asn Ser Ala Lys Gln  Gln Val Phe 
    1010                 1015                 1020             


Asp Thr  Val Phe Ala Leu Glu  Lys Lys Ile Val Gly  Thr Asp Pro 
    1025                 1030                 1035             


Asp Glu  Leu Lys Ser Leu Phe  Thr Asn Pro Lys Gly  Glu Pro Gln 
    1040                 1045                 1050             


Lys Gly  Asn Ile Gln His Lys  Pro Tyr Val Gln Trp  Leu Thr Asn 
    1055                 1060                 1065             


Lys Gly  Leu Ile Asn Lys Glu  Glu Lys Gln Phe Ile  Asn Met Val 
    1070                 1075                 1080             


Arg Lys  Cys Phe Ser His Asn  Gln Phe Pro Gln Arg  Lys Thr Met 
    1085                 1090                 1095             


Glu Leu  Leu Ile Pro Ala Trp  Asn Glu Lys Lys Leu  Ala Leu Gln 
    1100                 1105                 1110             


Ile Ala  Thr Val Tyr Asn Gln  Leu Ile Ala Asp Ile  Thr Asp Lys 
    1115                 1120                 1125             


Ile 
    


<210>  1521
<211>  1047
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1521

Met Glu Glu Gln Phe Leu Gln Lys Glu Arg Asn Met Gly Asp Asn Pro 
1               5                   10                  15      


Tyr Tyr Phe Cys His Phe Ile Asn Met Ala His His Asn Val Asn Leu 
            20                  25                  30          


Ile Leu Glu Glu Ile Tyr Asn Ser Val Tyr Glu Lys Tyr Thr Gln Asp 
        35                  40                  45              


Lys Glu Glu Asn Ile Lys Ala Ile Cys Asn Ser Met Ile Ser Lys Ser 
    50                  55                  60                  


Arg Lys Asn Pro Asp Glu Lys Ala Lys Met Met Asn Met Cys Ile Arg 
65                  70                  75                  80  


His Phe Pro Phe Leu Asp Tyr Tyr Lys Glu Lys Asp Gln Asn Ser Asp 
                85                  90                  95      


Val Leu Thr Ile Leu Leu Asn Gln Phe Leu Val Pro Leu His Gly Leu 
            100                 105                 110         


Arg Asn Gln Phe Ser His Tyr Lys His Pro Gln Glu Ala Tyr Cys Ile 
        115                 120                 125             


Ser Gly Phe Asp Leu Leu Phe Glu Gln Ala Lys Thr Gly Ala Gln Met 
    130                 135                 140                 


Arg Met Lys Tyr Ser Asp Glu Asp Ile Ser Lys Val Lys Ser Lys Val 
145                 150                 155                 160 


Val Asn His Asp Ser Ile Leu Thr Glu Arg Gly Ile Leu Phe Phe Ile 
                165                 170                 175     


Cys Leu Phe Leu Asp Lys Arg Asn Ile Tyr Leu Phe Leu Ser Lys Ile 
            180                 185                 190         


Lys Gly Phe Arg Asp Arg Arg Pro Asp Glu Lys Tyr Lys Ser Ala Thr 
        195                 200                 205             


Leu Glu Val Phe Ser Gln Tyr Tyr Cys His Val Pro Tyr Arg Lys Leu 
    210                 215                 220                 


Asp Ser Ser Asp Val Ala Leu Asp Met Leu Asn Glu Leu Asn Arg Cys 
225                 230                 235                 240 


Pro Lys Ala Leu Tyr Asp Val Leu Ser Asp Glu Asp Arg Glu Arg Phe 
                245                 250                 255     


Ile Val Asp Asn Val Glu Asn Ala Asp Asn Arg Asp Glu Ile Ser Asp 
            260                 265                 270         


Glu Asp Asp Glu Glu Met Pro Arg Ser Val Met Lys Arg Ser Asp Asp 
        275                 280                 285             


Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Glu Lys Gln Asn Asn Leu 
    290                 295                 300                 


Asp Glu Ile Ser Phe His Leu Tyr Leu Gly Arg Lys Glu Ala Lys Pro 
305                 310                 315                 320 


Ala His Glu Lys Val Ile Asn Gly Glu Met Arg Thr His Lys Ile Leu 
                325                 330                 335     


Lys Asp Ile His Val Phe Gly Arg Leu Glu Asn Tyr Arg Asn Glu Glu 
            340                 345                 350         


Ile Cys Asn Ala Ile Lys Asn Arg Glu Asp Ile Glu Phe Tyr Ala Pro 
        355                 360                 365             


Ser Tyr Arg Ile Val Glu Asn Arg Ile Gly Leu Leu Leu Arg Arg Gln 
    370                 375                 380                 


Asn Asp Phe Thr Leu Glu Glu Ala Asn Glu Glu Lys Ile Phe Glu Gly 
385                 390                 395                 400 


Asn Leu Cys Pro Asp Val Ile Leu Ser Thr His Glu Leu Gly Ala Leu 
                405                 410                 415     


Phe Phe Tyr Asn Tyr Leu His Lys Lys Gly Trp Ile Glu Ser Ala Pro 
            420                 425                 430         


Tyr Leu Tyr Ile Arg Asn Phe Ile Ser Asp Phe Lys Arg Phe Ile Glu 
        435                 440                 445             


Asp Ile Lys Asn Gly Lys Leu Thr Pro Val Glu Ser Glu Asp Asp Phe 
    450                 455                 460                 


Tyr Leu Ile Lys Lys Lys Lys Arg Asp Glu Thr Lys Asp Asn Asp Lys 
465                 470                 475                 480 


Lys Ser Ile Ala Val Gln Glu Arg Arg Arg Glu Lys Leu Lys Glu Lys 
                485                 490                 495     


Leu Lys Gly Tyr His Leu Glu Pro Asp Trp Ile Pro Asp Ala Cys Arg 
            500                 505                 510         


Glu Tyr Met Leu Gly Tyr Lys Ala Asp Gln Lys Asp Tyr Tyr Thr Lys 
        515                 520                 525             


Gln Arg Phe Cys Ser Met Lys Lys Glu Thr Asp Ser Arg Ile Lys Gln 
    530                 535                 540                 


Ile Glu Ala Ile Arg Lys Arg Glu Asp Asn Ser Ile Ile Arg Gln Thr 
545                 550                 555                 560 


Arg Val Gly Glu Ile Ala Gln Glu Leu Ala Arg Asp Ile Val Phe Leu 
                565                 570                 575     


Ile Pro Pro Tyr Lys Asn Glu Lys Gly Ala Asp Thr Lys Ile Asn Asn 
            580                 585                 590         


Met Glu Phe Asp Val Leu Gln Lys Met Leu Ala Tyr Phe Pro Leu Asn 
        595                 600                 605             


Lys Lys Asp Ile Tyr Pro Phe Leu Lys Asn Ile Arg Asn Trp Asp Lys 
    610                 615                 620                 


His Pro Phe Leu Lys Tyr Thr Leu His Thr Glu His Gln Ser Leu Leu 
625                 630                 635                 640 


Asp Phe Tyr Gln Asp Tyr Leu Asn Cys Lys Lys Arg Trp Ile Ser Lys 
                645                 650                 655     


Asn Ile Arg Tyr Asp Lys Gln Lys Gly Asn Tyr Leu Val Asp Ala Asn 
            660                 665                 670         


Lys Thr Glu Gln Glu Cys Arg Tyr Phe Leu Lys Thr Asp Lys Leu Arg 
        675                 680                 685             


Thr Ala Lys Glu Lys Glu Tyr Phe Glu Glu Pro Asp Lys Pro Val Tyr 
    690                 695                 700                 


Leu Pro Thr Gly Phe Phe Val Asp Pro Ile Val Glu Ala Met Arg Lys 
705                 710                 715                 720 


Asn Gly Tyr Glu Leu Lys Glu Asn Ser Asn Ile Val Gly Cys Leu Lys 
                725                 730                 735     


Ile Tyr Phe Val Ser Lys Ile Gln Pro Met Tyr Asp Leu Ser Arg Tyr 
            740                 745                 750         


Tyr Thr Tyr Tyr Asp Gly Lys Glu Glu Arg Ser Met Gln Leu Asp Asp 
        755                 760                 765             


Leu Lys Val Phe Ile Lys Glu Lys Phe Gly Asn Lys Arg Thr Asp Asp 
    770                 775                 780                 


Asn Thr Ile Arg Phe Leu Lys Lys Ala Ala Lys Arg Ile Arg Glu Asn 
785                 790                 795                 800 


Glu Ser Glu Ile Leu Val Arg Gln Met Asp Asp Cys Ala Leu Phe Leu 
                805                 810                 815     


Met Val Asn Asp Leu Leu Glu Gly Gly Lys Phe Asn Asp Glu Asp Ile 
            820                 825                 830         


Glu Asn Ile Gly Tyr Asn Lys His His Asn Leu Leu Asp His Glu Tyr 
        835                 840                 845             


Asp Met Cys Glu Thr Ile Tyr Gly Arg Lys Val Thr Ala Arg Leu Pro 
    850                 855                 860                 


Ile Lys Arg Tyr Gly Glu Phe Arg Arg Phe Met Lys Asp Arg Arg Leu 
865                 870                 875                 880 


Gln Asn Leu Val Lys Tyr Tyr Pro Gly Asp His Glu Thr Pro Ile Pro 
                885                 890                 895     


Ser Gly Ile Pro Glu Ser Gly Lys Ala Met Glu Lys Asn Lys Lys Tyr 
            900                 905                 910         


Thr Tyr Ser Asn Leu Cys Asp Glu Leu Glu Ile Tyr Asp Lys Glu Arg 
        915                 920                 925             


Asp Asn Val Leu Asn Leu Ile Tyr Glu Val Asp Lys Ile Leu Val Asp 
    930                 935                 940                 


His Phe Pro Asp Lys Ile Met Lys Glu Glu Asp Gly Tyr Tyr Glu His 
945                 950                 955                 960 


Tyr His Cys Leu Asp Phe Ala Lys Lys Glu Phe Gly Leu Glu Ser Asp 
                965                 970                 975     


Val Glu Leu Leu Ser Gln Asp Asn Phe Lys Asp Leu Arg Asn Ala Leu 
            980                 985                 990         


Tyr His Asn Gln Ile Pro Tyr Asn  Asp Trp Val Ala Asp  Lys Ile Ser 
        995                 1000                 1005             


Lys Asp  Thr Glu Glu Pro Met  Tyr Val Arg Arg Ile  Phe Ser Phe 
    1010                 1015                 1020             


Ile Arg  Thr Val Tyr Ser Arg  Leu Leu Asp Gln Ile  Lys Ile Lys 
    1025                 1030                 1035             


Ile Glu  Lys Asp Glu Tyr Lys  Cys Lys 
    1040                 1045         


<210>  1522
<211>  1140
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1522

Met Glu Asn Asp Gln Gln Ile Leu Glu Asn Arg Arg Arg Thr Leu Ala 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Ser Asn His Leu Ala Ala Ser Phe Glu Gln Lys Val 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ala Ser Phe Leu Cys Asn Lys Ser 
    50                  55                  60                  


Ile Lys Lys Ile Asn Trp Asn His Val Tyr Ser Lys Ala Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ala Asp Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Arg Glu Thr Thr Asp Lys Glu Gly Lys Asp Phe Thr Ala Met Asn Glu 
            100                 105                 110         


Thr Leu Lys Leu Val Phe Asp Glu Leu Gln Ala Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Ala Asp Ser Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Val Glu Leu Ala Asp Phe Leu Thr Val Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Ala Asp Asp Asp Tyr 
                165                 170                 175     


Thr Met Val Glu Ser Lys Gln Ile Val Thr Pro Asp Asn Leu Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Val Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Leu Ala Tyr Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asp Leu Gly Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Glu 
            260                 265                 270         


Val Ile Thr Glu Glu Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Glu Glu Glu Arg 
    290                 295                 300                 


Glu Lys Ile Leu Asp Glu Ile Asp Tyr Glu Asp Tyr Ile Glu Ser Leu 
305                 310                 315                 320 


Thr Arg Arg Val Arg His Ser Asn Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Lys Tyr Asn Lys Gln Phe Asp Gly Glu 
        355                 360                 365             


Ala Thr Glu Cys Lys Val Val Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asn Gln Glu Thr Val Glu Leu Lys Ile Asp Ser Ala 
385                 390                 395                 400 


Gln Arg Thr Asn Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Glu Ala Arg Leu Leu 
            420                 425                 430         


Thr Lys Ala Lys Pro Glu Ser Lys Val Ser Tyr Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Lys Ala Glu Glu Met Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Lys Val Asn Asp Ser Gln Leu Met Ser Met Gln Phe Ile Asp Glu 
                485                 490                 495     


Ile Lys Glu Gln Leu Pro Ala Asp Trp Asn Glu Phe Gly Lys Arg Ser 
            500                 505                 510         


Asp Ser Lys Lys Lys Lys Ala Tyr Thr Asn Ala Ala Leu Gln Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Lys Val Leu Ala Asn Tyr Gln Leu 
    530                 535                 540                 


Asn Asp Lys Gln Val Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Ser Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Val Glu Lys His Lys Leu 
            580                 585                 590         


Asp Lys Ser Ala Arg Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Thr Asp Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Phe Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Tyr 
625                 630                 635                 640 


Ala Asp Thr Asp Lys Lys Ala Thr Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Lys Gly Gly His Pro Phe Leu Ala Asn Ile Asn 
            660                 665                 670         


Leu Arg Gln Ile Arg Lys Thr Ser Gln Leu Tyr Glu Leu Tyr Leu Val 
        675                 680                 685             


Glu Lys Ala Asn Lys Gln Val Lys Lys Met Asn Pro Lys Thr Gln Arg 
    690                 695                 700                 


Thr Ser Asn Val Asp Glu Ser Trp Met Met Lys Ser Phe Tyr Ala Lys 
705                 710                 715                 720 


Glu Trp Asn Glu Glu Met Gly Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Val Asn Lys Thr Asn Ile Pro Phe Thr Ile Arg Gln Trp Glu Glu Lys 
            740                 745                 750         


Glu Lys His Asn Leu Gln Ala Trp Leu His Asn Ile Thr Lys Gly Lys 
        755                 760                 765             


Thr Ser Lys Asp Gly Lys Lys Ala Ile Asp Leu Pro Thr Asn Leu Phe 
    770                 775                 780                 


Asp Asp Thr Leu Cys Glu Leu Leu Arg Glu Ala Leu Ile Asn Gln Gly 
785                 790                 795                 800 


Ile Asp Ala Thr Pro Thr Thr Lys Tyr Asn Glu Leu Leu Lys Gln Trp 
                805                 810                 815     


Trp Thr Ala Arg Glu Asp Ser Thr Gln Asp Phe Tyr Leu Ser Glu Arg 
            820                 825                 830         


Gln Tyr Asp Ile Tyr Asp Glu Lys Val Cys Phe Thr Ile Asn Ser Ser 
        835                 840                 845             


Ala His Phe Ala Asp Tyr Tyr Ala Pro Ala Leu Asn Lys Ala Tyr Ser 
    850                 855                 860                 


Arg Leu Arg Ala Glu Arg Asp Val Ala Arg Arg Thr Asp Lys Arg Leu 
865                 870                 875                 880 


Pro Pro Val Glu Arg Lys Asp Val Glu Arg Val Phe Lys Asn Thr Ile 
                885                 890                 895     


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
            900                 905                 910         


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asn Gln Gln Gln Leu Lys 
        915                 920                 925             


Leu Ser Lys Met Asp Ser Leu Leu Asn Glu Thr Lys Arg Ile Glu Gln 
    930                 935                 940                 


Thr Ile Asn Thr Gln Leu Ser Phe Asp His Lys Gly Lys Glu Ile Lys 
945                 950                 955                 960 


Asp Lys Thr Asn Ser Glu Ile Val Lys Thr Ile Val Ala Glu Arg Lys 
                965                 970                 975     


Gln Lys Asn Tyr Thr Glu Met Arg Lys Tyr Val His Asp Arg Arg Leu 
            980                 985                 990         


Pro Glu Leu Phe Glu Tyr Ile Asp  Gly Asn Glu Leu Pro  Leu Asp Val 
        995                 1000                 1005             


Leu Leu  Asn Glu Leu Arg Ala  Tyr Asn Thr Ala Lys  Gln Met Val 
    1010                 1015                 1020             


Phe Asp  Thr Val Phe Ala Leu  Glu Lys Lys Ile Ile  Glu Thr Asp 
    1025                 1030                 1035             


Pro Glu  Gly Leu Lys Gln Leu  Asn Val Gly Lys Asn  Gly Gln Ile 
    1040                 1045                 1050             


Gln Thr  Gly Asn Ile Gln His  Lys Pro Tyr Val Gln  Trp Leu Glu 
    1055                 1060                 1065             


Asn Lys  Gly Leu Ile Thr Asp  His Gln Lys Gln Phe  Ile Asn Met 
    1070                 1075                 1080             


Val Arg  Asn Ser Phe Ser His  Asn Gln Phe Pro Gln  Arg Ser Thr 
    1085                 1090                 1095             


Val Glu  Leu Leu Met Pro Glu  Trp Gln Asn Thr Asp  Ile Ala Leu 
    1100                 1105                 1110             


Gln Ile  Ala Arg Glu Tyr Gln  Gln Leu Ile Val Asp  Ile Ile Glu 
    1115                 1120                 1125             


Lys Ser  Leu His Pro His Lys  Gln His Gln Met Val  
    1130                 1135                 1140 


<210>  1523
<211>  1118
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1523

Met Glu Asp Asp Lys Lys Thr Lys Glu Ser Thr Asn Met Leu Asp Asn 
1               5                   10                  15      


Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val Tyr 
            20                  25                  30          


Ile Thr Ile Asn His Ile Asn Lys Leu Leu Glu Ile Arg Glu Ile Asp 
        35                  40                  45              


Asn Asp Glu Lys Val Leu Asp Ile Lys Ala Leu Trp Gln Lys Val Asn 
    50                  55                  60                  


Gly Asp Leu Asn Lys Thr Glu Arg Leu Arg Glu Leu Met Thr Lys His 
65                  70                  75                  80  


Phe Pro Phe Leu Glu Thr Ala Ile Tyr Thr Lys Asn Lys Glu Asp Lys 
                85                  90                  95      


Lys Glu Val Lys Gln Glu Lys Gln Ala Lys Ala Gln Ser Phe Asp Ser 
            100                 105                 110         


Leu Lys His Cys Leu Phe Leu Phe Leu Glu Lys Leu Gln Glu Ala Arg 
        115                 120                 125             


Asn Tyr Tyr Ser His Tyr Lys Tyr Ser Glu Ser Thr Lys Glu Pro Met 
    130                 135                 140                 


Leu Glu Lys Glu Leu Leu Lys Lys Met Tyr Asn Ile Phe Asp Asp Asn 
145                 150                 155                 160 


Ile Gln Leu Val Ile Lys Asp Tyr Gln His Asn Lys Asp Ile Asn Pro 
                165                 170                 175     


Asp Glu Asp Phe Lys His Leu Asp Arg Thr Glu Glu Asp Phe Asn Tyr 
            180                 185                 190         


Tyr Phe Thr Arg Asn Lys Lys Gly Asn Ile Thr Ala Ser Gly Leu Leu 
        195                 200                 205             


Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Met Gln 
    210                 215                 220                 


Gln Lys Leu Arg Gly Phe Lys Asp Asn Arg Glu Ser Lys Lys Lys Met 
225                 230                 235                 240 


Thr His Glu Val Phe Cys Arg Ser Arg Met Leu Leu Pro Lys Leu Arg 
                245                 250                 255     


Leu Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu Asn 
            260                 265                 270         


Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Gln Gly Asp 
        275                 280                 285             


Asp Arg Lys Lys Phe Asn Val Pro Phe Asp Pro Ala Asp Glu Asp Tyr 
    290                 295                 300                 


Asp Ala Glu Gln Glu Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp 
305                 310                 315                 320 


Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Tyr Asn Glu Val Phe 
                325                 330                 335     


Thr Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile 
            340                 345                 350         


Tyr Lys Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg His Leu Thr His 
        355                 360                 365             


Lys Leu Tyr Gly Phe Glu Arg Ile Gln Glu Phe Ala Lys Gln Asn Arg 
    370                 375                 380                 


Pro Asp Glu Trp Lys Ala Ile Val Lys Asp Leu Asp Thr Tyr Glu Thr 
385                 390                 395                 400 


Ser Asn Glu Arg Tyr Ile Ser Glu Thr Thr Pro His Tyr His Leu Glu 
                405                 410                 415     


Asn Gln Lys Ile Gly Ile Arg Phe Arg Asn Gly Asn Lys Glu Ile Trp 
            420                 425                 430         


Pro Ser Leu Lys Thr Asn Gly Glu Asn Asn Glu Lys Ser Lys Tyr Lys 
        435                 440                 445             


Leu Asp Lys Gln Tyr Gln Ala Glu Ala Phe Leu Ser Val His Glu Leu 
    450                 455                 460                 


Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Lys Lys Glu Lys Pro Asn 
465                 470                 475                 480 


Asn Asp Glu Ile Asn Ala Ser Ile Val Glu Gly Phe Ile Lys Arg Glu 
                485                 490                 495     


Ile Arg Asp Ile Tyr Lys Leu Tyr Asp Ala Phe Ala Asn Gly Glu Ile 
            500                 505                 510         


Asn Asn Ile Asp Asp Leu Lys Lys Tyr Cys Glu Asp Lys Gly Ile Pro 
        515                 520                 525             


Lys Arg Asn Leu Pro Lys Gln Met Ile Ala Ile Leu Glu Ser Lys Pro 
    530                 535                 540                 


Lys Asp Met Val Glu Glu Ala Glu Arg Lys Gln Arg Lys Met Val Lys 
545                 550                 555                 560 


Asp Thr Lys Lys Leu Leu Ala Ala Leu Glu Lys Gln Thr Gln Gly Glu 
                565                 570                 575     


Ile Glu Asp Gly Gly Arg Asn Ile Arg Leu Leu Lys Ser Gly Glu Ile 
            580                 585                 590         


Ala Arg Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln Lys 
        595                 600                 605             


Asp Asn Glu Gly Asn Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu 
    610                 615                 620                 


Tyr Gln Met Leu Gln Arg Ser Leu Ala Leu Tyr Asn Lys Glu Glu Lys 
625                 630                 635                 640 


Pro Thr Arg Tyr Phe Arg Gln Val Asn Leu Ile Asn Ser Ser Asn Pro 
                645                 650                 655     


His Pro Phe Leu Lys Trp Thr Lys Trp Glu Glu Cys Asn Asn Ile Leu 
            660                 665                 670         


Ser Phe Tyr Arg Ser Tyr Leu Thr Lys Lys Ile Glu Phe Leu Asn Glu 
        675                 680                 685             


Leu Lys Pro Glu Asp Trp Glu Lys Asn Gln Tyr Phe Leu Lys Leu Lys 
    690                 695                 700                 


Glu Pro Lys Thr Asn Arg Glu Thr Leu Val Gln Gly Trp Lys Asn Gly 
705                 710                 715                 720 


Phe Asn Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg Glu Trp Phe 
                725                 730                 735     


Lys Arg His Gln Asn Asp Ser Lys Glu Tyr Glu Lys Val Glu Ala Leu 
            740                 745                 750         


Lys Arg Val Gly Leu Val Thr Lys Val Ile Pro Leu Phe Phe Lys Glu 
        755                 760                 765             


Glu Tyr Phe Lys Glu Asp Ala Gln Lys Glu Ile Asn Asn Cys Val Gln 
    770                 775                 780                 


Pro Phe Tyr Gly Phe Pro Tyr Asn Val Gly Asn Ile His Lys Pro Lys 
785                 790                 795                 800 


Glu Glu Asp Phe Leu His Arg Glu Glu Arg Ile Glu Leu Trp Asp Lys 
                805                 810                 815     


Lys Lys Asp Lys Phe Lys Gly Tyr Lys Ala Lys Lys Lys Phe Lys Glu 
            820                 825                 830         


Met Thr Asp Lys Glu Lys Glu Glu His Arg Ser Tyr Leu Glu Phe Lys 
        835                 840                 845             


Ser Trp Asn Gln Phe Glu Arg Glu Leu Arg Leu Val Arg Asn Gln Asp 
    850                 855                 860                 


Ile Val Thr Trp Leu Leu Cys Met Glu Leu Ile Asp Lys Leu Lys Val 
865                 870                 875                 880 


Glu Gly Leu Asn Val Glu Glu Leu Gln Lys Leu Arg Leu Lys Asp Ile 
                885                 890                 895     


Asp Thr Asp Thr Ala Lys Gln Glu Lys Asn Asn Ile Leu Asn Arg Val 
            900                 905                 910         


Met Pro Met Gln Leu Pro Val Thr Val Tyr Glu Ile Asp Asp Ser His 
        915                 920                 925             


Asn Ile Val Lys Asp Arg Pro Leu His Thr Val Tyr Ile Glu Glu Thr 
    930                 935                 940                 


Lys Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys Asp 
945                 950                 955                 960 


Arg Arg Leu Asn Gly Leu Phe Ser Phe Val Asp Thr Ser Ser Glu Ala 
                965                 970                 975     


Glu Leu Lys Ser Lys Pro Ile Ser Lys Leu Arg Val Glu Tyr Glu Leu 
            980                 985                 990         


Gly Glu Tyr Gln Asn Ala Arg Ile  Glu Ile Ile Glu Asp  Met Leu Ala 
        995                 1000                 1005             


Leu Glu  Gly Ala Leu Ile Glu  Lys Asp Lys Asn Leu  Pro Thr Asp 
    1010                 1015                 1020             


Asn Phe  Ser Asp Met Leu Asn  Gly Trp Leu Glu Gly  Lys Asp Glu 
    1025                 1030                 1035             


Ser Asp  Lys Ala Arg Phe Gln  Asn Asp Val Lys Leu  Leu Val Ala 
    1040                 1045                 1050             


Val Arg  Asn Ala Phe Ser His  Asn Gln Tyr Pro Met  Arg Asn Arg 
    1055                 1060                 1065             


Ile Ala  Phe Ala Asn Ile Asn  Pro Phe Ser Leu Ser  Ser Ala Asp 
    1070                 1075                 1080             


Ile Ser  Glu Glu Lys Gly Leu  Asn Ile Ala Asn Gln  Leu Lys Asp 
    1085                 1090                 1095             


Lys Thr  Lys Glu Thr Ile Asp  Lys Ile Ile Glu Ile  Glu Lys Pro 
    1100                 1105                 1110             


Ile Glu  Thr Lys Glu 
    1115             


<210>  1524
<211>  1148
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1524

Met Asp Asn Ser Thr Ser Lys Ser Phe Lys Arg Phe Phe Glu Phe Lys 
1               5                   10                  15      


Gly Asn Val Ala Pro Ile Ala Glu Lys Ala Asn Arg Asn Phe Asn Ile 
            20                  25                  30          


Lys Asn Leu Asn Pro Ile Asn Thr Gln Gln Arg Leu His Tyr Phe Ala 
        35                  40                  45              


Ile Gly His Val Phe Lys Ser Ile Asp Thr Glu Lys Ile Phe Thr Val 
    50                  55                  60                  


Leu Leu Asp Glu Val Ala Lys Val Lys Lys Pro Thr Lys Phe Ser Ala 
65                  70                  75                  80  


Leu Gln Asn Thr Glu Phe Thr Phe Ile Asn Glu Leu Lys Cys Leu Met 
                85                  90                  95      


Ser Asp Ile Arg Asn Ile Asn Ser His Phe Ile His Asp Phe Glu Lys 
            100                 105                 110         


Ile Lys Ile Asp Ser Ile Asp Lys Asn Ile Ile Glu Phe Leu Lys Gln 
        115                 120                 125             


Ser Phe Glu Leu Ala Val Leu Gln Thr Cys Met Asp Glu Lys Asn Ile 
    130                 135                 140                 


Asn Tyr Glu Glu Phe Thr Gly Gly Gly Asn Pro Glu Lys Glu Ile Val 
145                 150                 155                 160 


Asp Phe Leu Cys Asp Lys Phe Tyr Pro Lys Ile Asp Asn Ser Lys Asp 
                165                 170                 175     


Leu Ser Glu His Gln Lys Leu Ile Ser Asp Phe Lys Lys Lys Ser Lys 
            180                 185                 190         


Asp Glu Ala Ile Asn Glu Ile Leu Phe Ile Asn Val Ser Ser Asp Tyr 
        195                 200                 205             


Asn Trp Asn Ile Phe Glu Thr His Thr Val Phe Lys Ile Ser Lys Gly 
    210                 215                 220                 


Lys Tyr Leu Ser Phe Glu Ala Cys Leu Phe Leu Leu Ala Met Phe Leu 
225                 230                 235                 240 


Tyr Lys Gly Glu Ala Asn Gln Leu Ile Ser Lys Ile Lys Gly Phe Lys 
                245                 250                 255     


Arg Asn Asp Asp Asn Lys Phe Met Ser Lys Arg Asn Leu Phe Thr Phe 
            260                 265                 270         


Phe Ser Lys Lys Phe Ser Ser Gln Asp Ile Asp Ser Glu Glu Asn His 
        275                 280                 285             


Leu Val Lys Phe Arg Asp Leu Val Gln Tyr Leu Asn His Tyr Pro Thr 
    290                 295                 300                 


Val Trp Asn Lys Tyr Leu Glu Leu Gly Ser Asn Asn Pro Ile Met Thr 
305                 310                 315                 320 


Glu Arg Leu Lys Glu Lys Ile Ile Glu Leu Glu Ile Lys Arg Cys Phe 
                325                 330                 335     


Pro Glu Leu Ala Ser Asn Ser Ser Phe Asn Gln Phe Ala Ile Asn Tyr 
            340                 345                 350         


Ile Phe Lys Asn Gly Lys Ile Ile Glu Cys Glu Asn Asn Asn Ile Tyr 
        355                 360                 365             


Leu Asp Ile Ile Asn Lys Asn Asp Glu Val Arg Lys Ile Tyr Phe Ser 
    370                 375                 380                 


Ile Lys Asn Asn Glu Phe Asn Arg Ser Glu Phe Lys Asp Asn Ser Phe 
385                 390                 395                 400 


Lys Met Phe Ala Leu Lys Tyr Val Val Lys Glu Tyr Tyr Lys Glu Asn 
                405                 410                 415     


Lys Ala Tyr Ala Asp Tyr Leu Thr Lys Gln Ile Lys Asp Lys Glu Lys 
            420                 425                 430         


Thr Phe Asp Glu Glu Leu Ile Thr Asn Lys Lys Val Glu Lys Leu Lys 
        435                 440                 445             


Lys Gln Ile Ser Gln Asn Leu Asn Phe Ile Phe Tyr Gly Arg Asn Gln 
    450                 455                 460                 


Asp Arg Phe Met Glu Phe Ala Thr Arg Tyr Leu Ala Glu Thr Gly Tyr 
465                 470                 475                 480 


Phe Gly Lys Asp Ala Lys Phe Lys Met Tyr Glu Phe Phe Thr Thr Asp 
                485                 490                 495     


Glu Gln Ile Glu Glu Ile Asp Arg Leu Lys Arg Thr Ile Ser Lys Lys 
            500                 505                 510         


Glu Phe Asp Lys Leu Lys Phe His Gln Gly Lys Leu Val His Cys Ser 
        515                 520                 525             


Thr Tyr Ala Asp His Ile Ala Lys Tyr Lys Asn Trp Asp Thr Pro Phe 
    530                 535                 540                 


Val Val Glu Asn Asn Ala Val Gln Leu Thr Val Cys Phe Asp Asn Gly 
545                 550                 555                 560 


Gln Arg Lys Ile Leu Ser Ile Gln Arg Asn Leu Met Pro Tyr Phe Leu 
                565                 570                 575     


Glu Asp Ala Leu Tyr Asn Met Gln Asn Asp Lys Ile Glu Gly Ala Gly 
            580                 585                 590         


Lys Ile Leu Ile Glu Asn Tyr Tyr Asn Tyr His Lys Glu Gly Phe Glu 
        595                 600                 605             


Lys Ser Arg Leu Thr Leu Lys Gln Asn Asp Thr Ile Ser Leu Leu Glu 
    610                 615                 620                 


Lys Ala Thr Phe Lys Lys Ile Leu Pro Lys Arg Leu Leu His Arg Tyr 
625                 630                 635                 640 


Ser Pro Ala Val Gln Asn Asn Leu Pro Glu Asn Ser Thr Tyr Lys Gln 
                645                 650                 655     


Ile Leu Thr Lys Thr Lys Glu Ala Glu Glu Arg Tyr Val Lys Leu Leu 
            660                 665                 670         


Glu Lys Ala Lys Lys Asp Gly Tyr Glu Glu Asp Phe Leu Lys Arg Asn 
        675                 680                 685             


Lys Gly Lys Gln Phe Lys Leu Arg Phe Ile Arg Lys Ala Trp Asn Ile 
    690                 695                 700                 


Leu Phe Phe Lys Asp His Tyr Leu Lys Gln Val Gln Phe Ser Gly His 
705                 710                 715                 720 


His Arg Arg Phe Asn Ile Ser Arg Glu Glu Phe Asn Asp Phe Ser Lys 
                725                 730                 735     


Trp Met Phe Ala Phe Asp Glu Thr Pro Lys Tyr Lys Asp Tyr Leu Met 
            740                 745                 750         


Ile Leu Phe Glu Gln Lys Gly Phe Leu Glu Ile Ser Asn Phe Arg Thr 
        755                 760                 765             


Leu Phe Val Asn Ser Ser Ser Leu Asp Gly Leu Tyr Gly Lys Thr Lys 
    770                 775                 780                 


Ala Ile Tyr Glu Gly Trp Met Gln Asn Asn Asn Thr Asn Glu Lys Asn 
785                 790                 795                 800 


Pro Asp Lys Tyr Ser Leu Lys Asn Tyr Glu Lys Phe Phe Thr Asp Glu 
                805                 810                 815     


Leu Phe Tyr Ile Asn Val Ser His Phe Ile Ala Tyr Leu Asp Ile Ile 
            820                 825                 830         


Asn Lys Ile Arg Arg Asn Glu Lys Gly Gly Ile Ile Tyr Pro Cys Leu 
        835                 840                 845             


Glu Asn Glu Lys His Leu Ile Thr Glu Tyr Tyr Tyr Lys Val Lys Leu 
    850                 855                 860                 


Glu Glu Asn Glu Leu Lys Asn Cys Lys Lys Leu Phe Asn Lys Leu Met 
865                 870                 875                 880 


Ser Ala Lys Leu Glu Asp Ala Leu Leu Tyr Glu Ile Ser Met Tyr Tyr 
                885                 890                 895     


Leu Gly Ile Asp Asn Thr Ile Val Gln Lys Ala Arg Thr Asn Val Thr 
            900                 905                 910         


Asn Leu Leu Asn Gln Asp Val Val Phe Asn Ile Asn Asp Ala Asn Ser 
        915                 920                 925             


Asn His Leu Tyr Asp Leu Ser Ile Pro Phe Asn Lys Ile Asp Ser Tyr 
    930                 935                 940                 


Val Glu Leu Ile Lys His Lys Glu Asp Gln Glu Asn Asp Lys Lys Asn 
945                 950                 955                 960 


Lys Lys Thr Ser Phe Leu Gly Asn Met Pro Ser Tyr Ile Val Asn Val 
                965                 970                 975     


Ile Cys Lys Glu Thr Lys Asn Lys Glu Ser Cys Ser Ile Cys Asn Lys 
            980                 985                 990         


Tyr Ile Asn Phe Lys Lys Leu Asp  Phe Asp Asp Leu Asn  Lys Ile Asn 
        995                 1000                 1005             


Asn His  Ile Leu Ser Asn Ser  Val Lys Phe Thr Gln  Val Ala Leu 
    1010                 1015                 1020             


Ser Phe  Glu Glu Tyr Phe Ile  Phe Asn Glu Lys Lys  Ser Ile Ile 
    1025                 1030                 1035             


Lys Asn  Asn Arg Ile Asp Val  Asp Glu Phe Ser Phe  Trp Asn Ala 
    1040                 1045                 1050             


Tyr Phe  Ser Asp Ser Gly Leu  Thr Arg Lys Lys Ala  Phe His Phe 
    1055                 1060                 1065             


Gly Val  Pro Lys Glu Ser Tyr  Asp Asp Ile Ile Ala  Arg Met Glu 
    1070                 1075                 1080             


Asn Lys  Phe Val Lys Glu Gln  Ile Arg Pro Ser Leu  Pro Leu Asp 
    1085                 1090                 1095             


Tyr Asn  Ser Phe Asn Lys Gln  Gln Lys Ser Ile Cys  Asp Ala Leu 
    1100                 1105                 1110             


Leu Lys  Ser Ile His Ser Ser  Tyr Phe Asn His Arg  Glu Lys Asp 
    1115                 1120                 1125             


Lys Lys  Lys Lys Arg Asn Glu  Ala Asn Asn Met Tyr  Tyr Lys Glu 
    1130                 1135                 1140             


Val Ile  Leu Lys Lys 
    1145             


<210>  1525
<211>  1121
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1525

Met Asp Met Asp Glu Asn Ile Asn Tyr Tyr Asp Phe Asn Asn Ile Glu 
1               5                   10                  15      


Asp Lys His Phe Phe Ala Gly Tyr Tyr Asn Leu Ala Asn Asp Asn Phe 
            20                  25                  30          


Tyr Asn Val Leu Lys Glu Leu Lys Tyr Ile Ser Asp Lys Lys Leu Asp 
        35                  40                  45              


Ile Thr Glu Ile Asn Lys Ala Ser Tyr Ser Glu Leu Asp Thr Arg Leu 
    50                  55                  60                  


Asn Lys Leu Gln Arg Phe Leu Pro Phe Ile Pro Ser Leu Val Val Asp 
65                  70                  75                  80  


Lys Glu Ile Lys Asp Gln Lys Phe Glu Ile Thr Thr Leu Leu Lys Phe 
                85                  90                  95      


Leu Trp Ser Glu Ile Glu Lys Gln Arg Asn Phe Tyr Thr His Tyr Ala 
            100                 105                 110         


His Asn Arg Pro Glu Phe Ile Leu Glu Ser Asn Gln Gln Ile Leu Asn 
        115                 120                 125             


His Tyr Phe Ile Lys Ala Val Glu Leu Ile Lys Lys Ser Val Lys Asp 
    130                 135                 140                 


Glu Leu Cys Arg Asn Ser Ile Arg Glu His Phe Ser Val Glu Phe Asn 
145                 150                 155                 160 


Glu Leu Lys Val Leu Gln Lys Arg Tyr Ile Glu Glu Lys Ile Arg Asn 
                165                 170                 175     


Ser Lys Ser Asn Ser Glu Lys Lys Lys Tyr Ser Leu Asp Glu Glu Ser 
            180                 185                 190         


Ile Asn Asn Gly Ile Phe Asn Lys Leu Phe Lys Pro Tyr Ile Ile Lys 
        195                 200                 205             


Asp Lys Val Thr Gly Ile Leu Ser Ile Asn Asn Tyr Arg Leu Leu Phe 
    210                 215                 220                 


Asp Ser Ser Gly Tyr Leu Thr Lys His Gly His Leu Phe Leu Leu Ser 
225                 230                 235                 240 


Leu Phe Leu Lys Arg Asp Gln Met Glu Ser Leu Met Asp Lys Ile Glu 
                245                 250                 255     


Gly Tyr Lys Ala Ser His Lys Leu Tyr Phe His Leu Thr Arg Arg Ile 
            260                 265                 270         


Tyr Ser His Phe Cys Phe Lys Gly Ile Lys Arg Gln Ile Val Ser Gln 
        275                 280                 285             


His Ser Lys Thr Lys Leu Met Leu Gln Met Ala Asp Glu Leu Gly Lys 
    290                 295                 300                 


Ile Pro Glu Glu Leu Tyr Asn Leu Leu Asn Asn Asn Glu Lys Ala Glu 
305                 310                 315                 320 


Phe Ile Val Asp Ile Asn Glu Tyr Tyr Lys Asp Asn Asp Gln Asn Gly 
                325                 330                 335     


Glu Asn Pro Asp Glu Lys Arg Val Ile His Asp Val Val Arg Arg Arg 
            340                 345                 350         


Tyr Lys Gln Thr Asp Lys Ser Phe Ser Asp Thr Tyr Gly Thr Asn Lys 
        355                 360                 365             


Thr Ile Asp Lys Phe Glu Tyr Phe Ala Leu Arg Phe Phe Asp Glu Asp 
    370                 375                 380                 


Ser Lys Leu Lys Asn Ile Lys Phe Met Ile Asp Trp Gly Asn Val Ile 
385                 390                 395                 400 


Ile Asp Lys Arg Ser Lys Asn Ile Leu Asp Met Gln Thr Glu Arg Ile 
                405                 410                 415     


Ile Lys Lys Arg Val Thr Val Phe Glu Asn Ile Asn Thr Val Ile Asp 
            420                 425                 430         


Lys Lys Ile Glu Leu Val Asn Ser Asn Asn Cys Asn Gly Gln Ile Leu 
        435                 440                 445             


Ile Asp Glu Glu Asn Ser Thr Cys Leu Ile Glu Gly Tyr Pro Phe Pro 
    450                 455                 460                 


Ala Asn Pro Ser Tyr Tyr Phe Gln Gly His Asn Ile Pro Ile Tyr Leu 
465                 470                 475                 480 


Ser Tyr Asn Asn Lys Lys Glu Ala Asp Cys Glu Asp Thr Glu Ile Asn 
                485                 490                 495     


Lys Val Arg Asn Ala Val Leu Lys Asn Thr Leu Gly Asp Asn Val Phe 
            500                 505                 510         


Pro Asn Lys Pro Asn Ala Leu Leu Ser Leu Tyr Glu Leu Pro Ala Met 
        515                 520                 525             


Leu His Val Tyr Phe Asn His Ala Asn Lys Glu Lys Glu Val Phe Lys 
    530                 535                 540                 


Leu Leu Ile Asn Lys Tyr Phe Lys Tyr Lys Lys Asp Leu Asn Phe Lys 
545                 550                 555                 560 


Glu Asn Ile Asn Asp Asn Gln Leu Val His Leu Lys Lys Ile Lys Asn 
                565                 570                 575     


Asn Lys Ile Leu Leu Glu Lys Asn Glu Tyr Thr Phe Asn Arg Gln Lys 
            580                 585                 590         


Leu Val Ser Asp Ile Asn Lys Glu Ile Ile Lys Thr Glu Ile Lys Ile 
        595                 600                 605             


Asn Glu Phe Asn Lys Cys Lys Leu Glu Tyr His Asp Ile Lys Asn Lys 
    610                 615                 620                 


Arg Lys Tyr Leu Met Tyr Asn Ser Glu Lys Gly Leu Val Ala Thr Phe 
625                 630                 635                 640 


Leu Ala Asp Glu Ile Leu Arg Trp Met Pro Arg Asn Leu Lys Glu Asn 
                645                 650                 655     


Trp Lys Gly Tyr His His Ser Glu Leu Gln Lys Leu Leu Ser Phe Phe 
            660                 665                 670         


Gln Ile Glu Lys Asn Asn Ile Asn His Leu Ile Ile Phe Asp Asp Lys 
        675                 680                 685             


Phe Asp Phe Leu Arg Asp Ile Phe Lys Lys Ser Asn Ser Leu Glu Asp 
    690                 695                 700                 


Leu Tyr Ile Asn Tyr Leu Asn Gly Lys Ile Glu Lys Leu Lys Ser Phe 
705                 710                 715                 720 


Leu Ser Ile Leu Asp Ile Lys Glu Lys Lys Val Leu Lys Lys Gly Leu 
                725                 730                 735     


Cys Asp Ile Trp Val Phe Phe Lys Gln Ser Lys Tyr Asn Ile Lys Asn 
            740                 745                 750         


Ile Asn Ser Tyr Ser Glu Glu Leu Leu Lys Lys Pro Ile Leu Leu Gly 
        755                 760                 765             


Arg Gly Ile Phe Asp Asp Thr Pro Thr Phe Tyr Pro Ser Asp Leu Lys 
    770                 775                 780                 


Asp Asn Pro Lys Ala Asn Trp Phe Glu Thr Val Lys Lys Asn Gln Ser 
785                 790                 795                 800 


Tyr Gln Ser Phe Tyr Asn Leu Leu Glu Asp Lys Leu Lys Pro Val Ser 
                805                 810                 815     


Gly Glu Ser Ser Val Glu Lys Arg Arg Arg Ile Glu Lys Tyr Arg Ser 
            820                 825                 830         


Ile Glu Tyr Gln Lys Ile Lys Asp Ile Tyr Thr Leu Glu Met Phe Lys 
        835                 840                 845             


His Leu Tyr Lys Glu Ile Phe Gly Asn Glu Glu Ile Met Glu Asn Ile 
    850                 855                 860                 


Thr Leu Thr Asp Phe Tyr Gln Ser Pro Ala Glu Arg Lys Lys Met Ile 
865                 870                 875                 880 


Ala Asn Ala Ser Ser Gln Asn Asn Arg Asn Gln Gly Asn Cys Ser Lys 
                885                 890                 895     


Asn Lys Tyr Asn Glu Leu Gly Ile Trp Asn Lys Val Thr Pro Cys Asn 
            900                 905                 910         


Phe Glu Asn Gly Arg Val Val Ala Pro Gln Ile Lys Leu Lys Glu Ile 
        915                 920                 925             


Gly Lys Phe Glu Gln Leu Leu Leu Asp Asp Lys Val Lys Ala Ile Leu 
    930                 935                 940                 


Ser Tyr Asn Asp Gln Ile Trp Gln Lys Gln Glu Leu Glu Arg Glu Leu 
945                 950                 955                 960 


Glu Ser Tyr Arg Ile Val Arg Glu Glu Lys Leu Phe Lys Ile Ile His 
                965                 970                 975     


Asn Leu Glu Lys Val Ile Leu Glu Ile Glu Thr Leu His Arg Glu Asp 
            980                 985                 990         


Lys Ser His Pro Ile Ile Phe Asn  Asn Gly Glu Tyr Pro  Asn Phe Arg 
        995                 1000                 1005             


Lys Tyr  Ile Glu Asn Ser Lys  Ile Phe Asn Trp Ser  Gln Glu Asp 
    1010                 1015                 1020             


Lys Asn  Ile Ile Asn Cys Phe  Asn Ser Glu Leu Leu  Glu Asn Ser 
    1025                 1030                 1035             


Phe Pro  Glu Ile Ile Val Asn  Ala Asn Pro Arg Leu  Gln Lys Ala 
    1040                 1045                 1050             


Ile Leu  Leu Ile Tyr Ile Arg  Asn Lys Phe Ala His  Asn Gln Leu 
    1055                 1060                 1065             


Pro Ser  Lys His Val His Asn  Phe Cys Lys Lys Ile  Ser Cys Ile 
    1070                 1075                 1080             


Asn Asp  Glu Arg Val Thr Thr  Tyr Ala Glu Phe Tyr  Leu Met Ile 
    1085                 1090                 1095             


Val Glu  Asn Phe Ile Leu Asp  Gln Asn Phe Ile Lys  Thr Lys Gln 
    1100                 1105                 1110             


Val Tyr  Asn Asn Asn Ser Ile  Ser 
    1115                 1120     


<210>  1526
<211>  1169
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1526

Met Asp Thr Asn Ala Pro Lys Arg Tyr Thr Met Glu Thr Glu Pro Trp 
1               5                   10                  15      


Tyr Tyr Gly Gly Tyr Leu Asn Met Ala Arg His Asn Met Phe Leu Ile 
            20                  25                  30          


Ser Asn Glu Ile Val Thr Lys Leu Lys Leu Gly Phe Ala Lys Lys Lys 
        35                  40                  45              


Ala Asp Thr Ala Glu Ala Glu Pro Leu Ser Pro Lys Leu Leu Lys Asp 
    50                  55                  60                  


Asp Gly Ala Leu Pro Ser Ser Phe Leu Thr Asp Lys Asp Tyr Leu Glu 
65                  70                  75                  80  


Lys Asn Asn Pro Arg Arg Ile Tyr Ala Leu Leu Arg Arg Phe Leu Pro 
                85                  90                  95      


Leu Ala Ala Leu Phe Ala Thr Asp Thr Thr Ser Asp Glu Tyr Ser Glu 
            100                 105                 110         


Lys Glu Leu Asp Ile Ala Gln Met Ser Asp Ile Leu Lys Glu Leu Phe 
        115                 120                 125             


Ala Glu Leu Asn Arg Phe Arg Asn Asp Tyr Ser His Tyr Tyr Ser Val 
    130                 135                 140                 


Asp Arg Glu Asp Arg Arg Lys Thr Glu Leu Asp Glu Gln Val Ala Val 
145                 150                 155                 160 


Phe Leu Arg Asn Thr Phe Tyr Tyr Ala Ile His Leu Ala Arg Lys Arg 
                165                 170                 175     


Phe Glu Gly Val Ile Asp Ala Arg His Phe Gln Phe Val Glu Lys Glu 
            180                 185                 190         


Ile Ala Pro Gly Ile Val Arg Ala Asp Gly Lys Val Thr Thr Arg Gly 
        195                 200                 205             


Leu Val Phe Phe Cys Cys Leu Phe Leu Asp Lys Glu Asn Ala Phe His 
    210                 215                 220                 


Phe Ile Asn Lys Val Ser Gly Phe Lys Asn Thr Ser Thr Phe Asp Phe 
225                 230                 235                 240 


Leu Ala Thr Arg Glu Val Phe Ser Val Leu Cys Ala Lys Met Pro His 
                245                 250                 255     


Asp Arg Phe Ile Ser Glu Asn Pro Glu Gln Ala Leu Gln Leu Asp Ile 
            260                 265                 270         


Leu Asn Tyr Leu Asn Arg Ala Pro Ala Glu Leu Tyr Gln Ala Leu Ser 
        275                 280                 285             


Ala Glu Ala Lys Lys Pro Phe Gln Pro Gln Leu Gly Lys Asp Glu Arg 
    290                 295                 300                 


Tyr Asn Met Thr Gln Asn Ser Ile Pro Glu His Ile Glu Glu Glu Ser 
305                 310                 315                 320 


Tyr Glu Asn Tyr Leu Glu Ser Ile Ser Val Lys Arg Arg His Thr Asp 
                325                 330                 335     


Arg Phe Pro Glu Phe Ala Leu Lys Phe Leu Asp Arg Ser Asp Thr Phe 
            340                 345                 350         


Asp Phe Tyr Phe Gln Leu His Leu Gly Lys Ser Ile Phe Arg Ala Tyr 
        355                 360                 365             


Pro Lys Thr Leu Leu Gly Glu Thr Pro Glu Glu Pro Asn Arg Ser Ile 
    370                 375                 380                 


Ser Gly Asp Ile Lys Thr Phe Arg Asn Leu His Thr Phe Leu Gly Asn 
385                 390                 395                 400 


His Glu Glu Glu Arg Glu Gln Val Lys Ala Gln Ile Thr Ala Glu Ala 
                405                 410                 415     


Asp Phe Leu Lys Glu Phe Ser Gly Glu Tyr Ala Glu Tyr Phe Thr Gln 
            420                 425                 430         


Tyr Ala Pro His Phe His Ile Val Asn Asn Lys Ile Gly Ile Leu Pro 
        435                 440                 445             


Tyr Ser Asn Lys Lys Tyr His Glu Lys Leu Tyr Arg Pro Leu Ala Pro 
    450                 455                 460                 


Leu Ala Phe Leu Ser Val His Glu Leu Pro Lys Val Ala Leu Leu Glu 
465                 470                 475                 480 


Ile Leu Glu Pro Gly Ser Ala Ala Arg Cys Ile His Glu Cys Ile Gln 
                485                 490                 495     


Lys Ser Thr Ile Gln Val Leu Asn Asn Asp Phe Ile Glu Glu Val Lys 
            500                 505                 510         


Gln Ser Leu Ala Phe Asp Lys Glu Ile Lys Arg Gln Phe Trp Asp Asp 
        515                 520                 525             


Lys Leu Pro His Ile Glu Pro Ala Ala Ala Asp Lys Lys Ala Phe Asp 
    530                 535                 540                 


Asp Ile Arg Asn Lys Leu Asp Gln Glu Lys Lys Gly Arg Asn Arg Gln 
545                 550                 555                 560 


Ser Ala Thr Gln Asn Leu Asn Asn Arg Arg Lys Ala Leu Phe Tyr Ala 
                565                 570                 575     


Gln Tyr Val Ala Arg Val Asn Glu Arg Lys Glu Lys Leu Asn Thr Ile 
            580                 585                 590         


Leu Ala Glu Tyr Gly Leu Asn His Arg Gln Ile Pro Gly Arg Ile Leu 
        595                 600                 605             


Asp Tyr Trp Leu Arg Ile Val Glu Val Glu Thr Ala Ala Ala Ile Lys 
    610                 615                 620                 


Asn Arg Ile Arg Ala Glu Arg Lys Glu Cys Lys Gln Arg Ile Lys Ala 
625                 630                 635                 640 


Leu Asp Ala Gly Lys Gly Pro Lys Ile Gly Glu Met Ala Ser Tyr Leu 
                645                 650                 655     


Ala Arg Asp Ile Val Asn Leu Val Ile Asp Glu Lys Arg Lys Ala Lys 
            660                 665                 670         


Ile Ser Ser Phe Tyr Tyr Asp Gln Leu Gln Glu Cys Leu Ala Leu Tyr 
        675                 680                 685             


Ala Asp Ala Ala Lys Lys Gln Arg Phe Leu Asp Ile Cys Thr Lys Glu 
    690                 695                 700                 


Leu Gln Leu Phe Asp Thr Ala Asn Gly His Pro Phe Leu Ala Asp Leu 
705                 710                 715                 720 


Pro Phe Asn Lys Ile His Lys Thr Lys Asp Leu Tyr Arg Lys Tyr Ile 
                725                 730                 735     


Glu Arg Lys Gly Thr Ala Gln Arg Met Gly Lys Val Trp Asn Arg Lys 
            740                 745                 750         


Glu Lys Cys Phe Lys Ser Glu Lys Lys Glu Asp Ser Trp Leu Cys Asn 
        755                 760                 765             


Thr Phe Tyr Ser Lys Val Lys Ala Lys Asp Lys Thr Glu Ile Gln Ile 
    770                 775                 780                 


Pro Glu Ser Gly Lys Gly Val Pro Leu Ser Tyr Arg Arg Leu Ala Arg 
785                 790                 795                 800 


Glu Glu Ser Pro Leu Pro Ala Trp Leu His Ser Val Thr Lys Gly Asn 
                805                 810                 815     


Val Glu Lys Ala Asp Ser Lys Pro Ile Asp Leu Pro Leu Asn Leu Phe 
            820                 825                 830         


Asp Asp Cys Leu Asn Arg Leu Leu Thr Ala Glu Leu Gly Asp Arg Leu 
        835                 840                 845             


Gln Ala Gly Glu Lys Tyr Asn Tyr Ser Lys Leu Leu Ala Ile Trp Arg 
    850                 855                 860                 


Pro Glu Ile Gln Pro Phe Tyr Asn Trp Glu Arg Glu Tyr Val Leu Phe 
865                 870                 875                 880 


Lys Asp Glu Pro Tyr Glu Gly Arg Val Ala Phe Lys Pro Gly Ala Lys 
                885                 890                 895     


Ala Thr Phe Arg Glu Tyr Tyr Glu Pro Val Leu Asp Ser Val Tyr Arg 
            900                 905                 910         


Lys Arg Lys Arg Val Asp Pro Gln Ile Gln Glu Val Gln Val Arg Arg 
        915                 920                 925             


Val Phe Lys Lys Ala Ile Asp Glu Asn Glu Lys Gln Leu Arg Phe Tyr 
    930                 935                 940                 


Gln Ala Lys Asp Arg Ile Leu Met Leu Met Leu Asp Arg Met Ala Thr 
945                 950                 955                 960 


Glu Lys Leu Asn Ile Ser Leu Ala Glu Ile Tyr Pro Gly Ser Ala Thr 
                965                 970                 975     


Ser Pro Leu Asn Val Gln Thr Thr Ile Ser Glu Lys Ile Gly Asp Lys 
            980                 985                 990         


Tyr Asn Lys Tyr Ile Ser Tyr Thr  Arg Lys Arg Lys Asp  Tyr Ala Leu 
        995                 1000                 1005             


Phe Arg  Arg Phe Ile Thr Asp  Arg Arg Met His Gly  Leu Phe Ala 
    1010                 1015                 1020             


Trp Tyr  Thr Gln Asp Thr Ile  Ala Phe Glu Asp Leu  Lys Lys Glu 
    1025                 1030                 1035             


Leu Asp  Asp Tyr Glu Lys Leu  Arg Pro Gln Val Leu  Glu Met Cys 
    1040                 1045                 1050             


Phe Thr  Leu Glu Gln Ala Ile  Ile Ser His Met Ser  Lys Asp Glu 
    1055                 1060                 1065             


Leu Asp  Ala Met Ala Glu Lys  Ala Asn Ala Lys Ala  Ala Glu Lys 
    1070                 1075                 1080             


Asn Arg  Arg Asn Thr His Val  Glu His Gly Leu Tyr  Met Asp Trp 
    1085                 1090                 1095             


Leu Arg  Lys Tyr Ala Ile Ile  Thr Phe Glu Glu Glu  Thr Phe Tyr 
    1100                 1105                 1110             


Arg Glu  Ile Arg Asn Lys Phe  Ser His Asn Glu Phe  Pro Arg Ala 
    1115                 1120                 1125             


Asp Arg  Leu Pro Lys Ala Val  Arg Glu Ser Ser Asp  Gly Ile Thr 
    1130                 1135                 1140             


Ile Thr  His Ser Ile Val Thr  Tyr Tyr Leu Gln Glu  Leu Gln Lys 
    1145                 1150                 1155             


Leu Met  Glu Glu Lys Gly Val  Phe Thr Ala Leu 
    1160                 1165                 


<210>  1527
<211>  981
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1527

Met Ala Asp Lys Thr Ala Glu Leu Cys Leu Phe Tyr Asn Leu Ala Leu 
1               5                   10                  15      


Asn Arg Val Asn Asp Leu Val Arg Lys Tyr Glu Lys Asp Asp Thr Leu 
            20                  25                  30          


His Ile Glu Asp Val Asn Trp Glu Thr Phe Gly Gly Phe Arg Asn Val 
        35                  40                  45              


Ser Thr Tyr Leu His Leu Gln Val Phe Met Trp Lys Glu Pro Leu Ser 
    50                  55                  60                  


Ala Ser Phe Thr Thr Leu Ser Thr Ala Asp Lys Lys Arg Ile His Glu 
65                  70                  75                  80  


Leu Leu Arg Lys Leu Val Asp Leu Arg Asn Tyr Gln Ser His Tyr Tyr 
                85                  90                  95      


His Asp Ala Ser Val Leu Lys Phe Pro Gln Glu Leu Ile Asp Phe Ile 
            100                 105                 110         


Tyr Ser Arg Tyr Ala Asn Ala Arg Asn Ala Leu Glu Leu Lys Tyr Pro 
        115                 120                 125             


Glu Phe Val Thr Trp Phe His Asp Leu Asn Glu Asp Lys Val Ile Phe 
    130                 135                 140                 


Lys Asn Ser Lys Gly Glu Glu Arg Glu Asp Val Tyr Arg His Phe Tyr 
145                 150                 155                 160 


Phe Phe Asn Ala Asn Gly Asn Ile Glu Pro Glu Gly Lys Asn Phe Phe 
                165                 170                 175     


Leu Ser Phe Phe Leu Leu Lys Gly Glu Met Ser Lys Phe Leu Lys Lys 
            180                 185                 190         


Arg Ser Arg Cys Lys Arg Asp Asn Gly Glu Lys Tyr Gln Val Lys Thr 
        195                 200                 205             


Arg Leu Tyr Thr Tyr Tyr Cys His Arg Asp Gly Ser Asn Arg Phe Phe 
    210                 215                 220                 


Leu Glu Gly Lys Glu Glu Tyr Met Asp Thr Glu Glu Arg Leu Arg Arg 
225                 230                 235                 240 


Gln Gly Asn Thr Leu Leu Asn Tyr Leu Lys Ser Arg Pro Leu Val Asp 
                245                 250                 255     


Leu Lys Tyr Leu Pro Pro Ala Pro Pro Pro Gln Leu Leu Ser Lys Lys 
            260                 265                 270         


Glu Val Glu Glu Arg Lys Asn Arg Ala Glu Ser Gln Ala Glu Glu Glu 
        275                 280                 285             


Lys Thr Tyr Ile Arg Arg Thr Asp Lys Phe Ala Ser Leu Val Val Arg 
    290                 295                 300                 


Tyr Phe Met Asp Arg Ala Phe Leu Gly Tyr Glu Gln Glu Pro Cys Phe 
305                 310                 315                 320 


Tyr Trp His Val Lys Ser Leu Asp Leu Glu Glu Val Gln Lys Gln Lys 
                325                 330                 335     


Gln Glu Asn Arg Val Tyr Asp Ala Glu Gly Ala Tyr Tyr Tyr Gln Lys 
            340                 345                 350         


Glu Ser Arg Trp Ser Pro His Phe Val Pro Gly Glu Phe Pro Val Phe 
        355                 360                 365             


Val Asn Gly His Ile Lys Phe Arg Leu Gly Pro Glu Gly Met Glu Tyr 
    370                 375                 380                 


Ala Ile Ser Thr Gly Glu Leu Lys Asn Met Leu Tyr Leu Leu Leu Asn 
385                 390                 395                 400 


Ser Pro Arg Lys Asn Met Thr Glu Ile Gln Asp Ala Leu Leu Arg Tyr 
                405                 410                 415     


Gly Thr Gln Phe Ser Asn Ala Met Arg Glu Leu Thr Thr Glu His Asn 
            420                 425                 430         


Ile Arg Tyr Glu Ala Tyr Pro Leu Val Phe Glu Lys Gly Arg Asp Ser 
        435                 440                 445             


Val Leu Leu Ser Lys Met His Arg Lys Val Leu Asp Lys Glu Lys Phe 
    450                 455                 460                 


Asp Ala Ala Ile Tyr Thr Ala Ala Leu Glu Lys Ala Leu Asp Ser Arg 
465                 470                 475                 480 


Leu Arg Trp Val Glu Tyr Asn Cys Lys Pro Glu Val Tyr Thr Leu Tyr 
                485                 490                 495     


Thr Arg Asn Arg Met Asn Arg Ile Leu Leu Ser Cys Phe Asn Trp Tyr 
            500                 505                 510         


Leu Pro Asp Asp Ala Lys Leu Lys Pro Thr Glu Val Asn Lys Leu Ser 
        515                 520                 525             


Ile Tyr Asn Phe Val Ser Asp Asn Ser Tyr Thr Ser Asp Ala Thr Arg 
    530                 535                 540                 


Glu Ser Ile Val Val Gly Ile Gln Gln Lys Leu Asn Arg Ala Gln Phe 
545                 550                 555                 560 


Gly Ala Phe Ala Leu Leu Arg Thr Ala Ser Gly Leu Gln Asp Ala Tyr 
                565                 570                 575     


Leu Lys Met Leu Gly Lys Leu Arg Asp Ser Leu Leu Val Glu Lys Gln 
            580                 585                 590         


Gln Leu Leu Ala Gly Thr His Gly His Val Leu Lys Leu Gly Ala Arg 
        595                 600                 605             


Leu Gly Leu Ala Leu Pro Gly Thr Asp Val Ser Arg Asn Gly Thr Asp 
    610                 615                 620                 


Arg Met Gln Glu Leu Lys Gln Thr Ile Arg Ser Lys Pro Ile Leu Val 
625                 630                 635                 640 


Arg Asn Gly Phe Phe Lys Gln Tyr Phe Met Pro Glu Glu Pro Ala Ala 
                645                 650                 655     


Ala Arg Arg Asn Ser Ile Ser Ala Arg Leu Trp Lys Asn Arg Leu Leu 
            660                 665                 670         


Thr Gln Asn Leu Val Gln Gly Gln Tyr Lys Leu Gln Asn Gln Ser Glu 
        675                 680                 685             


Phe Ile Asn His Pro Glu Tyr Gly Leu Ala Asp Ile Ala Pro Asp Ile 
    690                 695                 700                 


Leu Ala Leu Val Gly Asp His Phe Asp Ala Cys Met Met Glu His Thr 
705                 710                 715                 720 


Gln Gly Ser Arg Gln Thr Phe Ala Gln Leu Val Asp Arg Phe Glu Ala 
                725                 730                 735     


Leu Tyr Thr Gly Ser Lys Ser Pro Glu Lys Arg Lys Gln Ile Ala Asp 
            740                 745                 750         


Ala Ile Asn Tyr Ser Arg Val Leu Lys Glu Ile Gln Ala Gln Asp Ala 
        755                 760                 765             


Leu Leu Leu Gln Val Phe Phe Glu Tyr His Asn Arg Lys Leu Pro Leu 
    770                 775                 780                 


Asn Arg Arg Glu Leu Lys Tyr Lys Pro Leu Ser Thr Leu Phe Glu Glu 
785                 790                 795                 800 


Glu Tyr Glu Leu Gln Ile Asp Ala Ser Tyr Lys Val Gln Leu Lys Tyr 
                805                 810                 815     


Lys Gln Leu Asp Asp Leu Ser Thr His Trp Asn Arg Thr Lys Ile Glu 
            820                 825                 830         


Gln Leu Phe Lys Asn Glu Ala Tyr Trp Asn Leu Ala Ile Ile Ala Glu 
        835                 840                 845             


Leu Asp Ala Lys Gly Lys Lys Ser Met Gln Glu Lys Ile Arg Ile Val 
    850                 855                 860                 


Met Asp Arg Val Trp Asn Asp Ser Tyr His Tyr Ile Lys Ala Phe Leu 
865                 870                 875                 880 


His Ile Glu Lys Glu Ala Val Glu Ile Gln Lys Lys Glu Gly Ile Pro 
                885                 890                 895     


Ala Thr Glu Leu Ile Ser Arg Ser Gln Ala Ile Arg Ser Pro Gly Leu 
            900                 905                 910         


Pro Arg Ile Glu Gly Lys Val Leu Leu Ser Thr Phe Ala Gly Leu Asp 
        915                 920                 925             


Glu Gly Lys Ile Asn Arg Phe Ile Gln Leu Arg Asn Ala Ala Phe His 
    930                 935                 940                 


Ala Gly Ile Pro Glu Glu Cys Val Lys Tyr Glu Lys Val Lys Asp Asp 
945                 950                 955                 960 


Leu Tyr Ala Ala Thr Gly Val Lys Lys Pro Val Val Lys Pro Lys Lys 
                965                 970                 975     


Tyr Glu Lys Lys Lys 
            980     


<210>  1528
<211>  981
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1528

Met Ala Asp Lys Thr Ala Glu Leu Cys Leu Phe Tyr Asn Leu Ala Leu 
1               5                   10                  15      


Asn Arg Val Asn Asp Leu Val Arg Lys Tyr Glu Lys Asp Asp Thr Leu 
            20                  25                  30          


His Ile Glu Asp Val Asn Trp Glu Thr Phe Gly Gly Phe Arg Asn Val 
        35                  40                  45              


Ser Thr Tyr Leu His Leu Gln Val Phe Met Trp Lys Glu Pro Leu Ser 
    50                  55                  60                  


Ala Ser Phe Thr Thr Leu Ser Thr Ala Asp Lys Lys Arg Ile His Glu 
65                  70                  75                  80  


Leu Leu Arg Lys Leu Val Asp Leu Arg Asn Tyr Gln Ser His Tyr Tyr 
                85                  90                  95      


His Asp Ala Ser Val Leu Lys Phe Pro Gln Glu Leu Ile Asp Phe Ile 
            100                 105                 110         


Tyr Ser Arg Tyr Ala Asn Ala Arg Asn Ala Leu Glu Leu Lys Tyr Pro 
        115                 120                 125             


Glu Phe Val Thr Trp Phe His Asp Leu Asn Glu Asp Lys Val Ile Phe 
    130                 135                 140                 


Lys Asn Ser Lys Gly Glu Glu Arg Glu Asp Val Tyr Arg His Phe Tyr 
145                 150                 155                 160 


Phe Phe Asn Ala Asn Gly Asn Ile Glu Pro Glu Gly Lys Asn Phe Phe 
                165                 170                 175     


Leu Ser Phe Phe Leu Leu Lys Gly Glu Met Ser Lys Phe Leu Lys Lys 
            180                 185                 190         


Arg Ser Arg Cys Lys Arg Asp Asn Gly Glu Lys Tyr Gln Val Lys Thr 
        195                 200                 205             


Arg Leu Tyr Thr Tyr Tyr Cys His Arg Asp Gly Ser Asn Arg Phe Phe 
    210                 215                 220                 


Leu Glu Gly Lys Glu Glu Tyr Met Asp Thr Glu Glu Arg Leu Arg Arg 
225                 230                 235                 240 


Gln Gly Asn Thr Leu Leu Asn Tyr Leu Lys Ser Arg Pro Leu Val Asp 
                245                 250                 255     


Leu Lys Tyr Leu Pro Pro Ala Pro Pro Pro Gln Leu Leu Ser Lys Lys 
            260                 265                 270         


Glu Val Glu Glu Arg Lys Asn Arg Ala Glu Ser Gln Ala Glu Glu Glu 
        275                 280                 285             


Lys Thr Tyr Ile Arg Arg Thr Asp Lys Phe Ala Ser Leu Val Val Arg 
    290                 295                 300                 


Tyr Phe Met Asp Arg Ala Phe Leu Gly Tyr Glu Gln Glu Pro Cys Phe 
305                 310                 315                 320 


Tyr Trp His Val Lys Ser Leu Asp Leu Glu Glu Val Gln Lys Gln Lys 
                325                 330                 335     


Gln Glu Asn Arg Val Tyr Asp Ala Glu Gly Ala Tyr Tyr Tyr Gln Lys 
            340                 345                 350         


Glu Ser Arg Trp Ser Pro His Phe Val Pro Gly Glu Phe Pro Val Phe 
        355                 360                 365             


Val Asn Gly His Ile Lys Phe Arg Leu Gly Pro Glu Gly Met Glu Tyr 
    370                 375                 380                 


Ala Ile Ser Thr Gly Glu Leu Lys Asn Met Leu Tyr Leu Leu Leu Asn 
385                 390                 395                 400 


Ser Pro Arg Lys Asn Met Thr Glu Ile Gln Asp Ala Leu Leu Arg Tyr 
                405                 410                 415     


Gly Thr Gln Phe Ser Asn Ala Met Arg Glu Leu Thr Thr Glu His Asn 
            420                 425                 430         


Ile Arg Tyr Glu Ala Tyr Pro Leu Val Phe Glu Lys Gly Arg Asp Ser 
        435                 440                 445             


Val Leu Leu Ser Lys Met His Arg Lys Val Leu Asp Lys Glu Lys Phe 
    450                 455                 460                 


Asp Ala Ala Ile Tyr Thr Ala Ala Leu Glu Lys Ala Leu Asp Ser Arg 
465                 470                 475                 480 


Leu Arg Trp Val Glu Tyr Asn Cys Lys Pro Glu Val Tyr Thr Leu Tyr 
                485                 490                 495     


Thr Arg Asn Arg Met Asn Arg Ile Leu Leu Ser Cys Phe Asn Trp Tyr 
            500                 505                 510         


Leu Pro Asp Asp Ala Lys Leu Lys Pro Thr Glu Val Asn Lys Leu Ser 
        515                 520                 525             


Ile Tyr Asn Phe Val Ser Asp Asn Ser Tyr Thr Ser Asp Ala Thr Arg 
    530                 535                 540                 


Glu Ser Ile Val Val Gly Ile Gln Gln Lys Leu Asn Arg Ala Gln Phe 
545                 550                 555                 560 


Gly Ala Phe Ala Leu Leu Arg Thr Ala Ser Gly Leu Gln Asp Ala Tyr 
                565                 570                 575     


Leu Lys Met Leu Gly Lys Leu Arg Asp Ser Leu Leu Val Glu Lys Gln 
            580                 585                 590         


Gln Leu Leu Ala Gly Thr His Gly His Val Leu Lys Leu Gly Ala Arg 
        595                 600                 605             


Leu Gly Leu Ala Leu Pro Gly Thr Asp Val Ser Arg Asn Gly Thr Asp 
    610                 615                 620                 


Arg Met Gln Glu Leu Lys Gln Thr Ile Arg Ser Lys Pro Ile Leu Val 
625                 630                 635                 640 


Arg Asn Gly Phe Phe Lys Gln Tyr Phe Met Pro Glu Glu Pro Ala Ala 
                645                 650                 655     


Ala Arg Arg Asn Ser Ile Ser Ala Arg Leu Trp Lys Asn Arg Leu Leu 
            660                 665                 670         


Thr Gln Asn Leu Val Gln Gly Gln Tyr Lys Leu Gln Asn Gln Ser Glu 
        675                 680                 685             


Phe Ile Asn His Pro Glu Tyr Gly Leu Ala Asp Ile Ala Pro Asp Ile 
    690                 695                 700                 


Leu Ala Leu Val Gly Asp His Phe Asp Ala Cys Met Met Glu His Thr 
705                 710                 715                 720 


Gln Gly Ser Arg Gln Thr Phe Ala Gln Leu Val Asp Arg Phe Glu Ala 
                725                 730                 735     


Leu Tyr Thr Gly Ser Lys Ser Pro Glu Lys Arg Lys Gln Ile Ala Asp 
            740                 745                 750         


Ala Ile Asn Tyr Ser Arg Val Leu Lys Glu Ile Gln Ala Gln Asp Ala 
        755                 760                 765             


Leu Leu Leu Gln Val Phe Phe Glu Tyr His Asn Arg Lys Leu Pro Leu 
    770                 775                 780                 


Asn Arg Arg Glu Leu Lys Tyr Lys Pro Leu Ser Thr Leu Phe Glu Glu 
785                 790                 795                 800 


Glu Tyr Glu Leu Gln Ile Asp Ala Ser Tyr Lys Val Gln Leu Lys Tyr 
                805                 810                 815     


Lys Gln Leu Asp Asp Leu Ser Thr His Trp Asn Arg Thr Lys Ile Glu 
            820                 825                 830         


Gln Leu Phe Lys Asn Glu Ala Tyr Trp Asn Leu Ala Ile Ile Ala Glu 
        835                 840                 845             


Leu Asp Ala Lys Gly Lys Lys Ser Met Gln Glu Lys Ile Arg Ile Val 
    850                 855                 860                 


Met Asp Arg Val Trp Asn Asp Ser Tyr His Tyr Ile Lys Ala Phe Leu 
865                 870                 875                 880 


His Ile Glu Lys Glu Ala Val Glu Ile Gln Lys Lys Glu Gly Ile Pro 
                885                 890                 895     


Ala Thr Glu Leu Ile Ser Arg Ser Gln Ala Ile Arg Ser Pro Gly Leu 
            900                 905                 910         


Pro Arg Ile Glu Gly Lys Val Leu Leu Ser Thr Phe Ala Gly Leu Asp 
        915                 920                 925             


Glu Gly Lys Ile Asn Arg Phe Ile Gln Leu Arg Asn Ala Ala Phe His 
    930                 935                 940                 


Ala Gly Ile Pro Glu Glu Cys Val Lys Tyr Glu Lys Val Lys Asp Asp 
945                 950                 955                 960 


Leu Tyr Ala Ala Thr Gly Val Lys Lys Pro Val Val Lys Pro Lys Lys 
                965                 970                 975     


Tyr Glu Lys Lys Lys 
            980     


<210>  1529
<211>  1169
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1529

Met Asp Thr Asn Ala Pro Lys Arg Tyr Thr Met Glu Thr Glu Pro Trp 
1               5                   10                  15      


Tyr Tyr Gly Gly Tyr Leu Asn Met Ala Arg His Asn Met Phe Leu Ile 
            20                  25                  30          


Ser Asn Glu Ile Val Thr Lys Leu Lys Leu Gly Phe Ala Lys Lys Lys 
        35                  40                  45              


Ala Asp Thr Ala Glu Ala Glu Pro Leu Ser Pro Lys Leu Leu Lys Asp 
    50                  55                  60                  


Asp Gly Ala Leu Pro Ser Ser Phe Leu Thr Asp Lys Asp Tyr Leu Glu 
65                  70                  75                  80  


Lys Asn Asn Pro Arg Arg Ile Tyr Ala Leu Leu Arg Arg Phe Leu Pro 
                85                  90                  95      


Leu Ala Ala Leu Phe Ala Thr Asp Thr Thr Ser Asp Glu Tyr Ser Glu 
            100                 105                 110         


Lys Glu Leu Asp Ile Ala Gln Met Ser Asp Ile Leu Lys Glu Leu Phe 
        115                 120                 125             


Ala Glu Leu Asn Arg Phe Arg Asn Asp Tyr Ser His Tyr Tyr Ser Val 
    130                 135                 140                 


Asp Arg Glu Asp Arg Arg Lys Thr Glu Leu Asp Glu Gln Val Ala Val 
145                 150                 155                 160 


Phe Leu Arg Asn Thr Phe Tyr Tyr Ala Ile His Leu Ala Arg Lys Arg 
                165                 170                 175     


Phe Glu Gly Val Ile Asp Ala Arg His Phe Gln Phe Val Glu Lys Glu 
            180                 185                 190         


Ile Ala Pro Gly Ile Val Arg Ala Asp Gly Lys Val Thr Thr Arg Gly 
        195                 200                 205             


Leu Val Phe Phe Cys Cys Leu Phe Leu Asp Lys Glu Asn Ala Phe His 
    210                 215                 220                 


Phe Ile Asn Lys Val Ser Gly Phe Lys Asn Thr Ser Thr Phe Asp Phe 
225                 230                 235                 240 


Leu Ala Thr Arg Glu Val Phe Ser Val Leu Cys Ala Lys Met Pro His 
                245                 250                 255     


Asp Arg Phe Ile Ser Glu Asn Pro Glu Gln Ala Leu Gln Leu Asp Ile 
            260                 265                 270         


Leu Asn Tyr Leu Asn Arg Ala Pro Ala Glu Leu Tyr Gln Ala Leu Ser 
        275                 280                 285             


Ala Glu Ala Lys Lys Pro Phe Gln Pro Gln Leu Gly Lys Asp Glu Arg 
    290                 295                 300                 


Tyr Asn Met Thr Gln Asn Ser Ile Pro Glu His Ile Glu Glu Glu Ser 
305                 310                 315                 320 


Tyr Glu Asn Tyr Leu Glu Ser Ile Ser Val Lys Arg Arg His Thr Asp 
                325                 330                 335     


Arg Phe Pro Glu Phe Ala Leu Lys Phe Leu Asp Arg Ser Asp Thr Phe 
            340                 345                 350         


Asp Phe Tyr Phe Gln Leu His Leu Gly Lys Ser Ile Phe Arg Ala Tyr 
        355                 360                 365             


Pro Lys Thr Leu Leu Gly Glu Thr Pro Glu Glu Pro Asn Arg Ser Ile 
    370                 375                 380                 


Ser Gly Asp Ile Lys Thr Phe Arg Asn Leu His Thr Phe Leu Gly Asn 
385                 390                 395                 400 


His Glu Glu Glu Arg Glu Gln Val Lys Ala Gln Ile Thr Ala Glu Ala 
                405                 410                 415     


Asp Phe Leu Lys Glu Phe Ser Gly Glu Tyr Ala Glu Tyr Phe Thr Gln 
            420                 425                 430         


Tyr Ala Pro His Phe His Ile Val Asn Asn Lys Ile Gly Ile Leu Pro 
        435                 440                 445             


Tyr Ser Asn Lys Lys Tyr His Glu Lys Leu Tyr Arg Pro Leu Ala Pro 
    450                 455                 460                 


Leu Ala Phe Leu Ser Val His Glu Leu Pro Lys Val Ala Leu Leu Glu 
465                 470                 475                 480 


Ile Leu Glu Pro Gly Ser Ala Ala Arg Cys Ile His Glu Cys Ile Gln 
                485                 490                 495     


Lys Ser Thr Ile Gln Val Leu Asn Asn Asp Phe Ile Glu Glu Val Lys 
            500                 505                 510         


Gln Ser Leu Ala Phe Asp Lys Glu Ile Lys Arg Gln Phe Trp Asp Asp 
        515                 520                 525             


Lys Leu Pro His Ile Glu Pro Ala Ala Ala Asp Lys Lys Ala Phe Asp 
    530                 535                 540                 


Asp Ile Arg Asn Lys Leu Asp Gln Glu Lys Lys Gly Arg Asn Arg Gln 
545                 550                 555                 560 


Ser Ala Thr Gln Asn Leu Asn Asn Arg Arg Lys Ala Leu Phe Tyr Ala 
                565                 570                 575     


Gln Tyr Val Ala Arg Val Asn Glu Arg Lys Glu Lys Leu Asn Thr Ile 
            580                 585                 590         


Leu Ala Glu Tyr Gly Leu Asn His Arg Gln Ile Pro Gly Arg Ile Leu 
        595                 600                 605             


Asp Tyr Trp Leu Arg Ile Val Glu Val Glu Thr Ala Ala Ala Ile Lys 
    610                 615                 620                 


Asn Arg Ile Arg Ala Glu Arg Lys Glu Cys Lys Gln Arg Ile Lys Ala 
625                 630                 635                 640 


Leu Asp Ala Gly Lys Gly Pro Lys Ile Gly Glu Met Ala Ser Tyr Leu 
                645                 650                 655     


Ala Arg Asp Ile Val Asn Leu Val Ile Asp Glu Lys Arg Lys Ala Lys 
            660                 665                 670         


Ile Ser Ser Phe Tyr Tyr Asp Gln Leu Gln Glu Cys Leu Ala Leu Tyr 
        675                 680                 685             


Ala Asp Ala Ala Lys Lys Gln Arg Phe Leu Asp Ile Cys Thr Lys Glu 
    690                 695                 700                 


Leu Gln Leu Phe Asp Thr Ala Asn Gly His Pro Phe Leu Ala Asp Leu 
705                 710                 715                 720 


Pro Phe Asn Lys Ile His Lys Thr Lys Asp Leu Tyr Arg Lys Tyr Ile 
                725                 730                 735     


Glu Arg Lys Gly Thr Ala Gln Arg Met Gly Lys Val Trp Asn Arg Lys 
            740                 745                 750         


Glu Lys Cys Phe Lys Ser Glu Lys Lys Glu Asp Ser Trp Leu Cys Asn 
        755                 760                 765             


Thr Phe Tyr Ser Lys Val Lys Ala Lys Asp Lys Thr Glu Ile Gln Ile 
    770                 775                 780                 


Pro Glu Ser Gly Lys Gly Val Pro Leu Ser Tyr Arg Arg Leu Ala Arg 
785                 790                 795                 800 


Glu Glu Ser Pro Leu Pro Ala Trp Leu His Ser Val Thr Lys Gly Asn 
                805                 810                 815     


Val Glu Lys Ala Asp Ser Lys Pro Ile Asp Leu Pro Leu Asn Leu Phe 
            820                 825                 830         


Asp Asp Cys Leu Asn Arg Leu Leu Thr Ala Glu Leu Gly Asp Arg Leu 
        835                 840                 845             


Gln Ala Gly Glu Lys Tyr Asn Tyr Ser Lys Leu Leu Ala Ile Trp Arg 
    850                 855                 860                 


Pro Glu Ile Gln Pro Phe Tyr Asn Trp Glu Arg Glu Tyr Val Leu Phe 
865                 870                 875                 880 


Lys Asp Glu Pro Tyr Glu Gly Arg Val Ala Phe Lys Pro Gly Ala Lys 
                885                 890                 895     


Ala Thr Phe Arg Glu Tyr Tyr Glu Pro Val Leu Asp Ser Val Tyr Arg 
            900                 905                 910         


Lys Arg Lys Arg Val Asp Pro Gln Ile Gln Glu Val Gln Val Arg Arg 
        915                 920                 925             


Val Phe Lys Lys Ala Ile Asp Glu Asn Glu Lys Gln Leu Arg Phe Tyr 
    930                 935                 940                 


Gln Ala Lys Asp Arg Ile Leu Met Leu Met Leu Asp Arg Met Ala Thr 
945                 950                 955                 960 


Glu Lys Leu Asn Ile Ser Leu Ala Glu Ile Tyr Pro Gly Ser Ala Thr 
                965                 970                 975     


Ser Pro Leu Asn Val Gln Thr Thr Ile Ser Glu Lys Ile Gly Asp Lys 
            980                 985                 990         


Tyr Asn Lys Tyr Ile Ser Tyr Thr  Arg Lys Arg Lys Asp  Tyr Ala Leu 
        995                 1000                 1005             


Phe Arg  Arg Phe Ile Thr Asp  Arg Arg Met His Gly  Leu Phe Ala 
    1010                 1015                 1020             


Trp Tyr  Thr Gln Asp Thr Ile  Ala Phe Glu Asp Leu  Lys Lys Glu 
    1025                 1030                 1035             


Leu Asp  Asp Tyr Glu Lys Leu  Arg Pro Gln Val Leu  Glu Met Cys 
    1040                 1045                 1050             


Phe Thr  Leu Glu Gln Ala Ile  Ile Ser His Met Ser  Lys Asp Glu 
    1055                 1060                 1065             


Leu Asp  Ala Met Ala Glu Lys  Ala Asn Ala Lys Ala  Ala Glu Lys 
    1070                 1075                 1080             


Asn Arg  Arg Asn Thr His Val  Glu His Gly Leu Tyr  Met Asp Trp 
    1085                 1090                 1095             


Leu Arg  Lys Tyr Ala Ile Ile  Thr Phe Glu Glu Glu  Thr Phe Tyr 
    1100                 1105                 1110             


Arg Glu  Ile Arg Asn Lys Phe  Ser His Asn Glu Phe  Pro Arg Ala 
    1115                 1120                 1125             


Asp Arg  Leu Pro Lys Ala Val  Arg Glu Ser Ser Asp  Gly Ile Thr 
    1130                 1135                 1140             


Ile Thr  His Ser Ile Val Thr  Tyr Tyr Leu Gln Glu  Leu Gln Lys 
    1145                 1150                 1155             


Leu Met  Glu Glu Lys Gly Val  Phe Thr Ala Leu 
    1160                 1165                 


<210>  1530
<211>  1189
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1530

Met Val Glu Phe Asp Lys Asn Arg Lys Tyr Ile Tyr Ala Ala Tyr Cys 
1               5                   10                  15      


Asn Met Ala Gln His Asn Phe Ile Ser Thr Leu Lys His Ile Ala Lys 
            20                  25                  30          


Cys Leu Ser Leu Asp Leu Glu Leu Thr Asp Lys Ser Lys Lys Ile Ile 
        35                  40                  45              


Asp Glu Leu Lys Asp Lys Val Asn Ser Leu Thr Gln Asp Lys Lys Leu 
    50                  55                  60                  


Lys Phe Tyr Glu Leu Leu Asn Lys His Phe Pro Phe Leu Ala Pro Met 
65                  70                  75                  80  


Ile Asp Ser Asp Lys Ser Ala Lys Asp Tyr Asn Glu Ile Lys Ala Ile 
                85                  90                  95      


Asn Asp Ile Leu Pro Gln Ile Gly Thr Val Val Asp Phe Tyr Arg Asp 
            100                 105                 110         


Tyr Thr Thr His Tyr Asp Pro Asp Glu Glu Lys Ser Val Asp Tyr Leu 
        115                 120                 125             


His Pro Ser Glu Gln Thr Leu Val Pro Arg Leu Lys Glu Leu Leu Lys 
    130                 135                 140                 


Ala Glu Ile Arg Thr Val Gln Gln Arg Phe Asn Tyr Val Glu Asp Glu 
145                 150                 155                 160 


Val Leu Phe Ile Lys Asn Lys Glu Met Asp Lys Glu Arg Tyr Arg Tyr 
                165                 170                 175     


Cys Leu Phe Lys Lys Leu Cys Arg Thr Asp Lys Lys Val Phe Ser Arg 
            180                 185                 190         


Arg Gly Leu Val Phe Phe Ile Ser Leu Phe Leu Glu Lys Lys Tyr Ile 
        195                 200                 205             


Asn Glu Met Leu Asn Lys Thr Lys Asp Phe Tyr Ala Lys Asp Asp Leu 
    210                 215                 220                 


Phe Asn Asp Lys Arg Lys His Ile Ile Phe Glu Ser Leu Ala Val Tyr 
225                 230                 235                 240 


Arg Ile Arg Leu Pro Arg Asn Arg Tyr Glu Ser Gln Gln Asp Asp Val 
                245                 250                 255     


Gly Leu Ala Leu Asp Met Val Asn Glu Leu Gln Arg Cys Pro Lys Glu 
            260                 265                 270         


Leu Phe Asp Leu Leu Ser Thr Glu Asp Gln Ile Lys Phe Arg Pro Asp 
        275                 280                 285             


Ala Ser Asp Glu Asp Ser Ser Lys Thr Ala Ile Met Ile Arg His Ala 
    290                 295                 300                 


Asp Arg Phe Pro Lys Leu Ala Met Asn Tyr Ile Asp Gln Cys Asn Val 
305                 310                 315                 320 


Phe Asn Ser Ile Arg Phe Gln Val Asn Leu Gly Lys Tyr Arg Tyr Ala 
                325                 330                 335     


Phe Tyr Asn Lys Lys Cys Ile Asp Gly Leu Asn His Val Arg Ser Leu 
            340                 345                 350         


Gln Lys Glu Leu His Gly Phe Gly Lys Leu Asn Glu Ile Glu Lys Ala 
        355                 360                 365             


Arg Leu Asp Thr Trp Gly Asn Leu Ile Arg Asp Phe Glu Asp Ile Lys 
    370                 375                 380                 


Thr Asn Thr Ile Asp Thr Met Pro Tyr Ile Asn Asp Gln Arg Ala Ser 
385                 390                 395                 400 


Tyr Ile Ile Asn Asn Asn Arg Ile Gly Leu Tyr Trp Glu Asp Lys Asp 
                405                 410                 415     


Asp Val Asn Glu Pro Lys Leu Val Leu Pro Lys Leu Pro Asn Glu Pro 
            420                 425                 430         


Thr Ala Lys Asn Leu Arg Gln Gln Lys Ala Asn Gly Glu Arg Ile Val 
        435                 440                 445             


Leu Leu Gln Ser Pro Lys Cys Phe Met Ser Thr His Glu Leu Pro Ala 
    450                 455                 460                 


Leu Ile Phe Tyr His Ile Ile Arg Lys Lys His Gln Lys Thr Asp Ser 
465                 470                 475                 480 


Pro Asp Val Glu Ser Ile Ile Ile Lys Trp Val Glu Gly Phe Arg Asn 
                485                 490                 495     


Phe Ile Gln Glu Val Met Asp Gly Lys Ile Thr Ser Gln Asn Ala Gln 
            500                 505                 510         


Glu Arg Ala Asn Gln Leu Gly Ile Asn Tyr Ala Gln His Leu Pro Lys 
        515                 520                 525             


Lys Ile Gln Glu Tyr Leu Asp Ala Asn Gln Asp Asn Asn Asn Ala Ile 
    530                 535                 540                 


Thr Ala Asn Leu Gln Lys Lys Leu Lys Asn Arg Leu Thr Thr His Ile 
545                 550                 555                 560 


Asp Glu Thr Lys Lys Leu Ile Glu Lys Tyr Asn Asn Val Lys His Val 
                565                 570                 575     


Asp Ser Lys Lys Asn Lys Arg Gly Thr Lys Arg Phe Val Glu Ile Lys 
            580                 585                 590         


Gln Gly Arg Leu Gly Ala Trp Leu Ala Gln Asp Ile Ile Ala Leu Gln 
        595                 600                 605             


Pro Ala Pro Ala Asp Gly Asn Asn Lys Leu Thr Gly Leu Asn Phe Gln 
    610                 615                 620                 


Leu Leu Gln Ser Ala Leu Ser Ile Tyr Asp Asn Phe Asp Asn Leu Lys 
625                 630                 635                 640 


Arg Leu Leu Ile Ala Ala His Leu Ile Gln Ser Lys Gly Asn His Pro 
                645                 650                 655     


Phe Leu Ser Glu Ile Val Ser Lys Ser Pro Gln Thr Ile Gly Asp Phe 
            660                 665                 670         


Tyr Gln Ala Tyr Leu Lys Ala Lys Leu Asn Trp Leu Asn Ser Leu Leu 
        675                 680                 685             


Ser Glu Glu Asp Leu Ile Lys Tyr Pro Phe Leu Thr Arg Gly Val Asn 
    690                 695                 700                 


Lys Trp Lys Phe Arg Asp Glu Glu Tyr Tyr Lys Ser Ile Met Gln Gln 
705                 710                 715                 720 


Tyr Leu Glu Leu Pro Ala Glu Leu Pro Arg Gly Leu Phe Glu Thr Ala 
                725                 730                 735     


Ile Lys Asp Ile Leu Ile Asp Cys Phe Gly Arg Gly Phe Val Arg Gly 
            740                 745                 750         


Asn Asn Arg Glu Glu Ala Asn Val Ala Phe Leu Ile Ala Lys Tyr Phe 
        755                 760                 765             


Lys Lys Val Phe Asn Asp Asp Tyr Gln Glu Phe Tyr Thr Gln Pro Asp 
    770                 775                 780                 


Gly Asn Tyr Lys Arg His Tyr Tyr Phe Phe Lys Leu Leu Leu Gln Ser 
785                 790                 795                 800 


Asp Lys Asp Tyr Gly Lys Thr Val Lys Glu Ile Glu Asp Ile Leu Arg 
                805                 810                 815     


Thr Asp Met Ser Leu Thr Leu Leu Ser Lys Thr Thr Ile Glu Asn Asp 
            820                 825                 830         


Asp Asp Ser Asp Asn Ser Asp Asn Ser Asp Leu Lys Glu Tyr Phe Glu 
        835                 840                 845             


Glu Ile Asn Lys Lys Leu Ala Lys Ser Leu Ala Lys Asp Pro Thr Leu 
    850                 855                 860                 


Asp Lys Arg His Arg Ile Glu Asp Ile Ile Ser Lys Ser Glu Thr Leu 
865                 870                 875                 880 


Ser Lys Leu Pro Asn Ser Gln Gln Lys Lys Leu Leu Arg Ile Ser Ser 
                885                 890                 895     


Lys Arg His Gly Val Pro Ile Asn Asp Gly Leu Val Lys Lys His Ile 
            900                 905                 910         


Lys Lys Ile Thr Ser Asn Ser Glu Lys Glu Glu Glu Leu Lys Lys Leu 
        915                 920                 925             


Ser His Ala Leu His Lys Leu Lys Ser Thr Glu Arg Leu Ile Arg Arg 
    930                 935                 940                 


Tyr Arg Val Gln Asp Ile Ile Ile Phe Met Met Ala Arg Glu Ile Leu 
945                 950                 955                 960 


Phe Glu Asn Asp Lys Asn Leu Phe Glu Asn Arg Phe Glu Glu Phe Lys 
                965                 970                 975     


Leu Lys Asn Ile Arg Pro Ile Arg Arg Gln Glu Gly Val Gly Ala Leu 
            980                 985                 990         


Glu Ile Lys Val Pro Phe Ala Ile  Thr Leu His Ile Lys  Gly Ser Asn 
        995                 1000                 1005             


Glu Ser  Val Val Ile Arg Gln  Lys Ser Ile Lys Leu  Lys Asn Tyr 
    1010                 1015                 1020             


Gly Asp  Phe His Lys Phe Leu  Tyr Asp Asn Arg Ile  Glu Thr Leu 
    1025                 1030                 1035             


Ile Pro  Tyr Leu Arg Asp Asp  Ala Asn Ala Val Lys  Val Thr Ile 
    1040                 1045                 1050             


Asp Arg  Asp Glu Leu Glu His  Glu Phe Glu Thr Tyr  Asp Lys Val 
    1055                 1060                 1065             


Arg Leu  Asp Val Phe Glu Ser  Val His Lys Ile Glu  Arg Leu Ile 
    1070                 1075                 1080             


Leu Glu  Arg Tyr Pro Glu Leu  His Asp Lys Arg Ser  Ser Leu Tyr 
    1085                 1090                 1095             


Tyr Phe  Glu Lys Lys Gly Val  Glu Lys Pro Ile Pro  Lys Lys Asn 
    1100                 1105                 1110             


Asn Phe  Arg Gln Leu Ile Glu  Cys Glu Pro Gln Phe  Ala Val Leu 
    1115                 1120                 1125             


Asp Lys  Asp Asp Cys Leu Asn  Ile Arg Asn Ser Phe  Ser His Asn 
    1130                 1135                 1140             


Ser Tyr  Asn Ser Lys Asp His  Glu Lys Val Asn Ile  Pro Ser Gly 
    1145                 1150                 1155             


Lys Ile  Gly Glu Ile Ala Glu  Leu Ile Ser Glu Arg  Met Lys Thr 
    1160                 1165                 1170             


Cys Leu  Asn Asn Phe Glu Lys  Lys Thr Arg Gln Glu  Asn Asp Ser 
    1175                 1180                 1185             


Glu 
    


<210>  1531
<211>  1140
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1531

Met Glu Asn Asp Gln Gln Ile Leu Glu Asn Arg Arg Arg Thr Leu Ala 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Ser Asn His Leu Ala Ala Ser Phe Glu Gln Lys Val 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ala Ser Phe Leu Cys Asn Lys Ser 
    50                  55                  60                  


Ile Lys Lys Ile Asn Trp Asn His Val Tyr Ser Lys Ala Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ala Asp Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Arg Glu Thr Thr Asp Lys Glu Gly Lys Asp Phe Thr Ala Met Asn Glu 
            100                 105                 110         


Thr Leu Lys Leu Val Phe Asp Glu Leu Gln Ala Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Ala Asp Ser Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Val Glu Leu Ala Asp Phe Leu Thr Val Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Ala Asp Asp Asp Tyr 
                165                 170                 175     


Thr Met Val Glu Ser Lys Gln Ile Val Thr Pro Asp Asn Leu Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Val Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Leu Ala Tyr Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asp Leu Gly Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Glu 
            260                 265                 270         


Val Ile Thr Glu Glu Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Glu Glu Glu Arg 
    290                 295                 300                 


Glu Lys Ile Leu Asp Glu Ile Asp Tyr Glu Asp Tyr Ile Glu Ser Leu 
305                 310                 315                 320 


Thr Arg Arg Val Arg His Ser Asn Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Lys Tyr Asn Lys Gln Phe Asp Gly Glu 
        355                 360                 365             


Ala Thr Glu Cys Lys Val Val Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asn Gln Glu Thr Val Glu Leu Lys Ile Asp Ser Ala 
385                 390                 395                 400 


Gln Arg Thr Asn Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Glu Ala Arg Leu Leu 
            420                 425                 430         


Thr Lys Ala Lys Pro Glu Ser Lys Val Ser Tyr Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Lys Ala Glu Glu Met Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Lys Val Asn Asp Ser Gln Leu Met Ser Met Gln Phe Ile Asp Glu 
                485                 490                 495     


Ile Lys Glu Gln Leu Pro Ala Asp Trp Asn Glu Phe Gly Lys Arg Ser 
            500                 505                 510         


Asp Ser Lys Lys Lys Lys Ala Tyr Thr Asn Ala Ala Leu Gln Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Lys Val Leu Ala Asn Tyr Gln Leu 
    530                 535                 540                 


Asn Asp Lys Gln Val Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Ser Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Val Glu Lys His Lys Leu 
            580                 585                 590         


Asp Lys Ser Ala Arg Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Thr Asp Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Phe Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Tyr 
625                 630                 635                 640 


Ala Asp Thr Asp Lys Lys Ala Thr Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Lys Gly Gly His Pro Phe Leu Ala Asn Ile Asn 
            660                 665                 670         


Leu Arg Gln Ile Arg Lys Thr Ser Gln Leu Tyr Glu Leu Tyr Leu Val 
        675                 680                 685             


Glu Lys Ala Asn Lys Gln Val Lys Lys Met Asn Pro Lys Thr Gln Arg 
    690                 695                 700                 


Thr Ser Asn Val Asp Glu Ser Trp Met Met Lys Ser Phe Tyr Ala Lys 
705                 710                 715                 720 


Glu Trp Asn Glu Glu Met Gly Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Val Asn Lys Thr Asn Ile Pro Phe Thr Ile Arg Gln Trp Glu Glu Lys 
            740                 745                 750         


Glu Lys His Asn Leu Gln Ala Trp Leu His Asn Ile Thr Lys Gly Lys 
        755                 760                 765             


Thr Ser Lys Asp Gly Lys Lys Ala Ile Asp Leu Pro Thr Asn Leu Phe 
    770                 775                 780                 


Asp Asp Thr Leu Cys Glu Leu Leu Arg Glu Ala Leu Ile Asn Gln Gly 
785                 790                 795                 800 


Ile Asp Ala Thr Pro Thr Thr Lys Tyr Asn Glu Leu Leu Lys Gln Trp 
                805                 810                 815     


Trp Thr Ala Arg Glu Asp Ser Thr Gln Asp Phe Tyr Leu Ser Glu Arg 
            820                 825                 830         


Gln Tyr Asp Ile Tyr Asp Glu Lys Val Cys Phe Thr Ile Asn Ser Ser 
        835                 840                 845             


Ala His Phe Ala Asp Tyr Tyr Ala Pro Ala Leu Asn Lys Ala Tyr Ser 
    850                 855                 860                 


Arg Leu Arg Ala Glu Arg Asp Val Ala Arg Arg Thr Asp Lys Arg Leu 
865                 870                 875                 880 


Pro Pro Val Glu Arg Lys Asp Val Glu Arg Val Phe Lys Asn Thr Ile 
                885                 890                 895     


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
            900                 905                 910         


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asn Gln Gln Gln Leu Lys 
        915                 920                 925             


Leu Ser Lys Met Asp Ser Leu Leu Asn Glu Thr Lys Arg Ile Glu Gln 
    930                 935                 940                 


Thr Ile Asn Thr Gln Leu Ser Phe Asp His Lys Gly Lys Glu Ile Lys 
945                 950                 955                 960 


Asp Lys Thr Asn Ser Glu Ile Val Lys Thr Ile Val Ala Glu Arg Lys 
                965                 970                 975     


Gln Lys Asn Tyr Thr Glu Met Arg Lys Tyr Val His Asp Arg Arg Leu 
            980                 985                 990         


Pro Glu Leu Phe Glu Tyr Ile Asp  Gly Asn Glu Leu Pro  Leu Asp Val 
        995                 1000                 1005             


Leu Leu  Asn Glu Leu Arg Ala  Tyr Asn Thr Ala Lys  Gln Met Val 
    1010                 1015                 1020             


Phe Asp  Thr Val Phe Ala Leu  Glu Lys Lys Ile Ile  Glu Thr Asp 
    1025                 1030                 1035             


Pro Glu  Gly Leu Lys Gln Leu  Asn Val Gly Lys Asn  Gly Gln Ile 
    1040                 1045                 1050             


Gln Thr  Gly Asn Ile Gln His  Lys Pro Tyr Val Gln  Trp Leu Glu 
    1055                 1060                 1065             


Asn Lys  Gly Leu Ile Thr Asp  His Gln Lys Gln Phe  Ile Asn Met 
    1070                 1075                 1080             


Val Arg  Asn Ser Phe Ser His  Asn Gln Phe Pro Gln  Arg Ser Thr 
    1085                 1090                 1095             


Val Glu  Leu Leu Met Pro Glu  Trp Gln Asn Thr Asp  Ile Ala Leu 
    1100                 1105                 1110             


Gln Ile  Ala Arg Glu Tyr Gln  Gln Leu Ile Val Asp  Ile Ile Glu 
    1115                 1120                 1125             


Lys Ser  Leu His Pro His Lys  Gln His Gln Met Val  
    1130                 1135                 1140 


<210>  1532
<211>  1129
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1532

Met Glu Thr Asn Gln Gln Thr His Glu Asn Arg Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Asn Asn His Val Ala Thr Asp Phe Lys Arg Lys Pro 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Asp Ala Leu Leu Cys Asn Lys Thr 
    50                  55                  60                  


Ile Lys Asn Leu Asn Trp Asn His Val His Thr Arg Ala Leu Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ser Glu Ser Leu Pro Lys Asp Glu 
                85                  90                  95      


Arg Lys Asn Ser Asp Thr Glu Gly Lys Asp Phe Thr Ser Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Ser Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Asp Ser Arg Lys Leu Ile Val 
    130                 135                 140                 


Ser Pro Glu Leu Ala Asn Phe Leu Thr Ile Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Thr Tyr Thr Lys Ala Arg Met Lys Asp Val Leu Thr Asp Ala Asp Tyr 
                165                 170                 175     


Ala Leu Val Glu Asn Leu Gln Met Val Ala Thr Asp Asn Lys Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ala Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asn Gln Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Ser 
            260                 265                 270         


Ile Ile Thr Asp Lys Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Glu Asn Leu Ile Ala Asn Ser Thr Asn Asn Glu Glu Arg 
    290                 295                 300                 


Glu Arg Ile Leu Asp Glu Ile Asp Tyr Gln Asp Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg Tyr Asn Asn Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Asp Glu Lys Asn Ile Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Asn Tyr Thr Lys Gln Phe Ala Gly Glu 
        355                 360                 365             


Gln Ala Glu Arg Lys Val Leu Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asp Pro Glu Leu Ser Gln Gln Arg Ile Asp Lys Gln 
385                 390                 395                 400 


Gln Gln Thr Ala Gly Phe Glu Gln Phe Ala Pro Arg Tyr His Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Asn Ile Ala Thr Leu Thr 
            420                 425                 430         


Ala Lys Ser Lys Ala Gly Ser Lys Val Glu His Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Gln Ala Glu Glu Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Ile Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Ser Gln Leu Pro Asp Gly Trp Asn Glu Phe Asn Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asp Ser Thr Leu Arg Tyr Leu 
        515                 520                 525             


His Gln Arg Lys Thr Ile Leu Asn Thr Ile Leu Ser Lys Tyr Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Lys Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Thr Arg Leu Lys Ala Val Glu Lys His Lys Leu 
            580                 585                 590         


Asn Lys Ser Val Lys Ile Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Glu Glu Lys Lys Lys Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Thr Asn Ala Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Asn Asp Gly His Pro Phe Leu Gln Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Gln Ala Tyr Leu Ile 
        675                 680                 685             


Glu Lys Gly Asn Lys Met Val Pro Arg Leu Asn Pro Lys Thr Asn Lys 
    690                 695                 700                 


Thr Ser Lys Val Asp Glu Ser Trp Met Met Lys Gln Phe Tyr Val Lys 
705                 710                 715                 720 


Glu Trp Lys Glu Glu Ile Ala Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Ser Arg Ile Pro Phe Thr Ile Arg Gln Trp Asp Glu Lys 
            740                 745                 750         


Glu Lys Tyr Asp Leu Asn Thr Trp Leu Arg His Val Thr Val Gly Lys 
        755                 760                 765             


Asn Asn Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe Asp 
    770                 775                 780                 


Glu Ala Leu Cys Asp Leu Leu Arg Glu Gln Leu Asp Thr Lys Ile Val 
785                 790                 795                 800 


Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Ile Trp Trp 
                805                 810                 815     


Lys Thr Arg Asn Asp Asp Thr Gln Gln Phe Tyr Gln Ser Glu Arg Glu 
            820                 825                 830         


Tyr Asn Ile Tyr Asn Glu Lys Val Arg Phe Lys Ile Asp Ser Ser Ala 
        835                 840                 845             


His Phe Ala Asp Tyr Tyr Lys Asn Ala Leu Ser Arg Ala Phe Thr Arg 
    850                 855                 860                 


Leu Lys Ala Glu Arg Glu Thr Ala Arg Gln Ser Asn Lys Arg Leu Pro 
865                 870                 875                 880 


Pro Leu Glu Tyr Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile Ala 
                885                 890                 895     


Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met Ala 
            900                 905                 910         


Val Leu Met Leu Glu Arg Leu Met Asp Asn Ser Pro Asn Leu Arg Leu 
        915                 920                 925             


Ser Lys Ile Glu Thr Leu Leu Asn Asp Thr Thr Pro Ile Arg Glu Lys 
    930                 935                 940                 


Ile Ser Ala Thr Leu Ser Phe Asp Ala Ser Gly Glu Arg Ile Ser Gly 
945                 950                 955                 960 


Lys Ser Asn Pro Thr Val Thr Lys Thr Leu Val Ala Glu Arg Lys Gln 
                965                 970                 975     


Lys Asn Tyr Thr Glu Leu Arg Lys Tyr Arg Tyr Asp Arg Arg Leu Pro 
            980                 985                 990         


Glu Leu Phe Glu Tyr Val Gln Ala  Asp Glu Ile Pro Leu  Glu Trp Leu 
        995                 1000                 1005             


Leu Glu  Glu Leu Ser Ala Tyr  Asn Asn Ala Lys Gln  Gln Val Phe 
    1010                 1015                 1020             


Asp Thr  Val Phe Thr Leu Glu  Lys Lys Ile Ile Gly  Thr Asp Pro 
    1025                 1030                 1035             


Asp Gly  Leu Lys Ser Leu Phe  Thr Gly Ala Asn Gly  Glu Leu Gln 
    1040                 1045                 1050             


Thr Gly  Asn Ile Gln His Lys  Pro Tyr Val Gln Trp  Leu Thr Asn 
    1055                 1060                 1065             


Lys Gly  Leu Ile Asn Lys Glu  Glu Lys Gln Phe Ile  Asn Met Val 
    1070                 1075                 1080             


Arg Lys  Cys Phe Ser His Asn  Gln Phe Pro Gln Arg  Lys Thr Met 
    1085                 1090                 1095             


Glu Leu  Leu Ile Pro Ala Trp  Asn Glu Lys Lys Leu  Ala Leu Gln 
    1100                 1105                 1110             


Ile Ala  Thr Val Tyr Asn Gln  Leu Ile Ala Asp Leu  Thr Asn Lys 
    1115                 1120                 1125             


Ile 
    


<210>  1533
<211>  1081
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1533

Met Gln Ala Gln Ser Leu Phe Asp Glu Tyr Lys His Leu Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Val Met Ser Ile Met Asn Ile Ile Thr Val Leu Asn His Ile 
            20                  25                  30          


His Gln Ile Ala Gly Leu Lys Arg Asn Glu Leu Gly Asp Asp Asp Asn 
        35                  40                  45              


Ile Tyr Ser His Pro Val Leu Lys Tyr Ile Ala Pro Glu Asn Asn Ser 
    50                  55                  60                  


Thr Thr Leu Pro Glu Lys Arg Asp Leu Ile Lys Glu Leu Leu Leu Glu 
65                  70                  75                  80  


Tyr Leu Pro Phe Leu Glu Ala Met Lys Asp Cys Tyr Lys Glu Val Lys 
                85                  90                  95      


Val Glu Lys Asp Lys Arg Asn Asn Lys Tyr Val Lys Asp Lys Lys Gln 
            100                 105                 110         


Val Phe Ile Arg Asn Tyr Ser Asp Ile Tyr Cys Ile Tyr Trp Thr Leu 
        115                 120                 125             


Tyr Asn Ile Phe Ser Thr Leu Ile Asn Tyr Arg Asp Lys Ser Cys His 
    130                 135                 140                 


Tyr Arg Phe Ile Pro Ser Lys Asp Gln Glu Glu Tyr Ser Lys Arg Thr 
145                 150                 155                 160 


Glu Tyr Asp Thr Val Arg Ile Ile Asn Lys Tyr Tyr Thr Tyr Ala Leu 
                165                 170                 175     


Arg Lys Thr Lys Glu Lys Tyr Gly Tyr Thr Thr Glu Gln Leu Ser Phe 
            180                 185                 190         


Ile Gln Asn Asn Arg Tyr Thr Asp Asp Lys Lys Val Asn Phe Asn Phe 
        195                 200                 205             


Phe Leu Ser Met Gln Ser Ser Asn Asn Asn Leu Ser His Val Gly Val 
    210                 215                 220                 


Ala Gln Leu Ile Cys Leu Phe Leu Gln Lys Lys Asp Val Asp Asn Phe 
225                 230                 235                 240 


Leu Glu Asn Leu Pro Ile Tyr Asp Asn Arg Tyr Cys Leu Gly Ile Asp 
                245                 250                 255     


Glu His Met Ile Ile Lys Arg Ser Leu Ala Leu His Ser Ile Lys Leu 
            260                 265                 270         


Pro Lys Glu Arg Leu Asn Ser Glu Lys Lys Asp Met Ala Ile Ala Met 
        275                 280                 285             


Asp Met Leu Asn Glu Leu Lys Arg Cys Pro Lys Glu Leu Phe Asn Thr 
    290                 295                 300                 


Leu Pro Phe Asp Lys Gln Glu Arg Phe Arg Ile Ile Ser Ser Asp His 
305                 310                 315                 320 


Lys Glu Val Leu Leu Met Arg Ser Thr Asp Arg Phe Val Pro Leu Ile 
                325                 330                 335     


Leu Gln Tyr Ile Asp Cys Asn Lys Lys Phe Lys Asp Ile Arg Phe His 
            340                 345                 350         


Val Asn Met Gly Lys Leu Arg Tyr Leu Phe Ser Pro Asn Lys Leu Cys 
        355                 360                 365             


Ile Asp Asn Gln Glu Arg Val Arg Met Leu Glu His Leu Leu Asn Gly 
    370                 375                 380                 


Tyr Gly Arg Ile Asp Glu Val Glu Tyr Leu Arg Lys Ala Pro Asn Gly 
385                 390                 395                 400 


Thr Phe Gly Asn Thr Asn Ile Pro Ile Lys Gly Phe Gly Glu Ile Glu 
                405                 410                 415     


Arg Asp Ser Ala Asp Ser Asn Asn Tyr Pro Tyr Ile Val Asp Thr His 
            420                 425                 430         


Thr His Tyr Ile Leu Asn Asn Asn Lys Val Glu Phe Cys Phe Cys Glu 
        435                 440                 445             


Asp Ser Lys Asn Lys Asn Val Phe Pro Thr Ile Glu Lys Glu Ile Asn 
    450                 455                 460                 


Gly Lys Trp Tyr Val Glu Lys Thr Ala Pro His Cys Arg Ile Ser Phe 
465                 470                 475                 480 


Phe Glu Ile Pro Ala Met Ala Phe His Met Phe Leu Cys Gly Ser Glu 
                485                 490                 495     


Lys Thr Glu Lys Leu Ile Lys Asp Val Tyr Asn Asn Tyr Ile Ser Leu 
            500                 505                 510         


Phe Asn Ala Leu Lys Asn Gly Ala Leu Thr Glu Glu Asn Tyr Lys Asp 
        515                 520                 525             


Phe Asn Ile Pro Glu Cys Asp Met Pro Lys Lys Ile Leu Asp Phe Leu 
    530                 535                 540                 


Lys Gly Lys Ala Glu Gly Lys Ser Ile Asp Gly Tyr Val Lys Asn Ile 
545                 550                 555                 560 


Leu Lys Lys Glu Leu Lys Asp Thr Arg Lys Arg Ile Glu Gln Ala Pro 
                565                 570                 575     


Ser Glu Lys Asp Gln Met Pro Ser Lys Arg Asn Lys Ile Gly Thr Lys 
            580                 585                 590         


Ser Tyr Lys Arg Val Leu Thr Gly Lys Leu Ala Asp Phe Leu Ala Lys 
        595                 600                 605             


Asp Ile Val Lys Tyr Gln Pro Thr Leu Cys Ala Gly Asp Asp Tyr Gly 
    610                 615                 620                 


Ile Asp Arg Met Thr Gly Met Asn Tyr Arg Ile Met Gln Ala Thr Ile 
625                 630                 635                 640 


Ala Thr Tyr Asn Asp Asp Asp Asp Phe Asp Thr Phe Tyr Asn Val Phe 
                645                 650                 655     


Lys Met Ala Gly Leu Val Asp Gly Asp Glu Arg Lys Asn His Pro Phe 
            660                 665                 670         


Leu Lys Lys Val Leu Leu Ser Lys Pro Gln Asn Thr Val Ala Phe Asn 
        675                 680                 685             


Ile Lys Tyr Leu Lys Glu Lys Glu Ile Tyr Leu Arg Asn Ile Glu Lys 
    690                 695                 700                 


Lys Asn Ile Ile Pro Pro Phe Val Asn Arg Glu Arg Asn Lys Trp Cys 
705                 710                 715                 720 


Glu Arg Asp Cys Glu Tyr Tyr Arg Ile Leu Gly Glu Asn Leu Leu Asp 
                725                 730                 735     


Leu Pro Ile Glu Leu Pro Arg Gln Met Phe Tyr Lys Asp Ile Arg Ala 
            740                 745                 750         


Gln Leu Glu Pro Leu Met Pro Glu Ile Asp Phe Ser Gln Thr Asn Thr 
        755                 760                 765             


Thr Tyr Leu Ile Ala Glu Tyr Leu Lys Arg Val Arg Gly Asp Asp Phe 
    770                 775                 780                 


Gln Glu Phe Tyr Ser Trp Glu Arg Asn Tyr Arg Tyr Ile Asp Phe Leu 
785                 790                 795                 800 


Lys Cys Ile Arg Asp Asp Asn Gly Arg Ile Cys Ala Gln Tyr Thr Thr 
                805                 810                 815     


Thr Glu Glu Arg Glu Ser Leu Trp Glu Asp Ser Lys Asn Arg Thr Ala 
            820                 825                 830         


Glu Tyr Lys Arg Ser Glu Glu Gln Lys Asn Glu Lys Lys Asp Lys Asn 
        835                 840                 845             


Phe Glu Asp Ser Leu Glu Glu Arg Ile Ser Ser Ser His Ile Lys Phe 
    850                 855                 860                 


Gln Asn Thr Glu Lys His Ile Arg Arg Tyr Lys Val Gln Asp Ala Leu 
865                 870                 875                 880 


Leu Phe Met Ile Ala Glu Lys Gln Phe Gly Lys Tyr Leu Asp Asp Ile 
                885                 890                 895     


Lys Ala Lys Asn Phe Lys Leu Lys Asp Ile Met Pro Asp Thr Asp Lys 
            900                 905                 910         


Gly Ile Leu Ser Glu Thr Met Pro Ile Asp Phe Thr Phe Thr Lys Lys 
        915                 920                 925             


Asn Ile Lys Tyr Asn Ile His Ala Lys Asn Leu Lys Phe Lys Glu Tyr 
    930                 935                 940                 


Gly Asp Leu Phe Ile Leu Ala Asn Asp Lys Arg Leu Glu Ser Leu Trp 
945                 950                 955                 960 


Lys Ile Leu Ala Thr Asp Thr Val Asn Lys Glu Glu Ile Ser Glu Glu 
                965                 970                 975     


Phe Ala Lys Tyr Asp Phe Cys Arg Pro Asp Ile Thr Lys Leu Val Leu 
            980                 985                 990         


Asp Phe Glu Lys Asp Val Leu Glu  Lys Tyr Pro Glu Ile  Ile Glu Glu 
        995                 1000                 1005             


Ala Glu  Lys Glu Tyr Lys Lys  Phe Asp Phe Lys Phe  Ile Leu Asp 
    1010                 1015                 1020             


Trp Leu  Ile Asn Lys Lys Lys  Leu Asn Tyr Gly Ile  Arg Asn Lys 
    1025                 1030                 1035             


Leu Leu  Leu Ile Arg Asn Ala  Phe Asn His Asn Ser  Tyr Pro Asp 
    1040                 1045                 1050             


Lys Lys  Tyr Ala Glu Val Arg  Glu Leu Pro Glu Ile  Ala Thr Asn 
    1055                 1060                 1065             


Leu Lys  Lys Thr Phe Asp Glu  Asn Ala Lys Lys Tyr  Glu 
    1070                 1075                 1080     


<210>  1534
<211>  1081
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1534

Met Gln Ala Gln Ser Leu Phe Asp Glu Tyr Lys His Leu Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Val Met Ser Ile Met Asn Ile Ile Thr Val Leu Asn His Ile 
            20                  25                  30          


His Gln Ile Ala Gly Leu Lys Arg Asn Glu Leu Gly Asp Asp Asp Asn 
        35                  40                  45              


Ile Tyr Ser His Pro Val Leu Lys Tyr Ile Ala Pro Glu Asn Asn Ser 
    50                  55                  60                  


Thr Thr Leu Pro Glu Lys Arg Asp Leu Ile Lys Glu Leu Leu Leu Glu 
65                  70                  75                  80  


Tyr Leu Pro Phe Leu Glu Ala Met Lys Asp Cys Tyr Lys Glu Val Lys 
                85                  90                  95      


Val Glu Lys Asp Lys Arg Asn Asn Lys Tyr Val Lys Asp Lys Lys Gln 
            100                 105                 110         


Val Phe Ile Arg Asn Tyr Ser Asp Ile Tyr Cys Ile Tyr Trp Thr Leu 
        115                 120                 125             


Tyr Asn Ile Phe Ser Thr Leu Ile Asn Tyr Arg Asp Lys Ser Cys His 
    130                 135                 140                 


Tyr Arg Phe Ile Pro Ser Lys Asp Gln Glu Glu Tyr Ser Lys Ser Thr 
145                 150                 155                 160 


Glu Tyr Asp Thr Val Arg Ile Ile Asn Lys Tyr Tyr Thr Tyr Ala Leu 
                165                 170                 175     


Arg Lys Thr Lys Glu Lys Tyr Gly Tyr Thr Thr Glu Gln Leu Ser Phe 
            180                 185                 190         


Ile Gln Asn Asn Arg Tyr Thr Asp Asp Lys Lys Val Asn Phe Asn Phe 
        195                 200                 205             


Phe Leu Ser Met Gln Ser Ser Asn Asn Asn Leu Ser His Val Gly Val 
    210                 215                 220                 


Ala Gln Leu Ile Cys Leu Phe Leu Gln Lys Lys Asp Val Asp Asn Phe 
225                 230                 235                 240 


Leu Glu Asn Leu Pro Ile Tyr Asp Asn Arg Tyr Cys Leu Gly Ile Asp 
                245                 250                 255     


Glu His Met Ile Ile Lys Arg Ser Leu Ala Leu His Ser Ile Lys Leu 
            260                 265                 270         


Pro Lys Glu Arg Leu Asn Ser Glu Lys Lys Asp Met Ala Ile Ala Met 
        275                 280                 285             


Asp Met Leu Asn Glu Leu Lys Arg Cys Pro Lys Glu Leu Phe Asn Thr 
    290                 295                 300                 


Leu Pro Phe Asp Lys Gln Glu Arg Phe Arg Ile Ile Ser Ser Asp His 
305                 310                 315                 320 


Lys Glu Val Leu Leu Met Arg Ser Thr Asp Arg Phe Val Pro Leu Ile 
                325                 330                 335     


Leu Gln Tyr Ile Asp Cys Asn Lys Lys Phe Lys Asp Ile Arg Phe His 
            340                 345                 350         


Val Asn Met Gly Lys Leu Arg Tyr Leu Phe Ser Pro Asn Lys Leu Cys 
        355                 360                 365             


Ile Asp Asn Gln Glu Arg Val Arg Met Leu Glu His Leu Leu Asn Gly 
    370                 375                 380                 


Tyr Gly Arg Ile Asp Glu Val Glu Tyr Leu Arg Lys Ala Pro Asn Gly 
385                 390                 395                 400 


Thr Phe Gly Asn Thr Asn Ile Pro Ile Lys Gly Phe Gly Glu Ile Glu 
                405                 410                 415     


Arg Asp Ser Ala Asp Ser Asn Asn Tyr Pro Tyr Ile Val Asp Thr His 
            420                 425                 430         


Thr His Tyr Ile Leu Asn Asn Asn Lys Val Glu Phe Cys Phe Cys Glu 
        435                 440                 445             


Asp Ser Lys Asn Lys Asn Val Phe Pro Thr Ile Glu Lys Glu Ile Asn 
    450                 455                 460                 


Gly Lys Trp Tyr Val Glu Lys Thr Ala Pro His Cys Arg Ile Ser Phe 
465                 470                 475                 480 


Phe Glu Ile Pro Ala Met Ala Phe His Met Phe Leu Cys Gly Ser Glu 
                485                 490                 495     


Lys Thr Glu Lys Leu Ile Lys Asp Val Tyr Asn Asn Tyr Ile Ser Leu 
            500                 505                 510         


Phe Asn Ala Leu Lys Asn Gly Ala Leu Thr Glu Glu Asn Tyr Lys Asp 
        515                 520                 525             


Phe Asn Ile Pro Glu Cys Asp Met Pro Lys Lys Ile Leu Asp Phe Leu 
    530                 535                 540                 


Lys Gly Lys Ala Glu Gly Lys Ser Ile Asp Gly Tyr Val Lys Asn Ile 
545                 550                 555                 560 


Leu Lys Lys Glu Leu Lys Asp Thr Arg Lys Arg Ile Glu Gln Ala Pro 
                565                 570                 575     


Ser Glu Lys Asp Gln Met Pro Ser Lys Arg Asn Lys Ile Gly Thr Lys 
            580                 585                 590         


Ser Tyr Lys Arg Val Leu Thr Gly Lys Leu Ala Asp Phe Leu Ala Lys 
        595                 600                 605             


Asp Ile Val Lys Tyr Gln Pro Thr Leu Cys Ala Gly Asp Asp Tyr Gly 
    610                 615                 620                 


Ile Asp Arg Met Thr Gly Met Asn Tyr Arg Ile Met Gln Ala Thr Ile 
625                 630                 635                 640 


Ala Thr Tyr Asn Asp Asp Asp Asp Phe Asp Thr Phe Tyr Asn Val Phe 
                645                 650                 655     


Lys Met Ala Gly Leu Val Asp Gly Asp Glu Arg Lys Asn His Pro Phe 
            660                 665                 670         


Leu Lys Lys Val Leu Leu Ser Lys Pro Gln Asn Thr Val Ala Phe Asn 
        675                 680                 685             


Ile Lys Tyr Leu Lys Glu Lys Glu Ile Tyr Leu Arg Asn Ile Glu Lys 
    690                 695                 700                 


Lys Asn Ile Ile Pro Pro Phe Val Asn Arg Glu Arg Asn Lys Trp Cys 
705                 710                 715                 720 


Glu Arg Asp Cys Glu Tyr Tyr Arg Ile Leu Gly Glu Asn Leu Leu Asp 
                725                 730                 735     


Leu Pro Ile Glu Leu Pro Arg Gln Met Phe Tyr Lys Asp Ile Arg Ala 
            740                 745                 750         


Gln Leu Glu Pro Leu Met Pro Glu Ile Asp Phe Ser Gln Thr Asn Thr 
        755                 760                 765             


Thr Tyr Leu Ile Ala Glu Tyr Leu Lys Arg Val Arg Gly Asp Asp Phe 
    770                 775                 780                 


Gln Glu Phe Tyr Ser Trp Glu Arg Asn Tyr Arg Tyr Ile Asp Phe Leu 
785                 790                 795                 800 


Lys Cys Ile Arg Asp Asp Asn Gly Arg Ile Cys Ala Gln Tyr Thr Thr 
                805                 810                 815     


Thr Glu Glu Arg Glu Ser Leu Trp Glu Asp Ser Lys Asn Arg Thr Ala 
            820                 825                 830         


Glu Tyr Lys Arg Ser Glu Glu Gln Lys Asn Glu Lys Lys Asp Lys Asn 
        835                 840                 845             


Phe Glu Asp Ser Leu Glu Glu Arg Ile Ser Ser Ser His Ile Lys Phe 
    850                 855                 860                 


Gln Asn Thr Glu Lys His Ile Arg Arg Tyr Lys Val Gln Asp Ala Leu 
865                 870                 875                 880 


Leu Phe Met Ile Ala Glu Lys Gln Phe Gly Lys Tyr Leu Asp Asp Ile 
                885                 890                 895     


Lys Ala Lys Asn Phe Lys Leu Lys Asp Ile Met Pro Asp Thr Asp Lys 
            900                 905                 910         


Gly Ile Leu Ser Glu Thr Met Pro Ile Asp Phe Thr Phe Thr Lys Lys 
        915                 920                 925             


Asn Ile Lys Tyr Asn Ile His Ala Lys Asn Leu Lys Phe Lys Glu Tyr 
    930                 935                 940                 


Gly Asp Leu Phe Ile Leu Ala Asn Asp Lys Arg Leu Glu Ser Leu Trp 
945                 950                 955                 960 


Lys Ile Leu Ala Thr Asp Thr Val Asn Lys Glu Glu Ile Ser Glu Glu 
                965                 970                 975     


Phe Ala Lys Tyr Asp Phe Cys Arg Pro Asp Ile Thr Lys Leu Val Leu 
            980                 985                 990         


Asp Phe Glu Lys Asp Val Leu Glu  Lys Tyr Pro Glu Ile  Ile Glu Glu 
        995                 1000                 1005             


Ala Glu  Lys Glu Tyr Lys Lys  Phe Asp Phe Lys Phe  Ile Leu Asp 
    1010                 1015                 1020             


Trp Leu  Ile Asn Lys Lys Lys  Leu Asn Tyr Gly Ile  Arg Asn Lys 
    1025                 1030                 1035             


Leu Leu  Leu Ile Arg Asn Ala  Phe Asn His Asn Ser  Tyr Pro Asp 
    1040                 1045                 1050             


Lys Lys  Tyr Ala Glu Val Arg  Glu Leu Pro Glu Ile  Ala Thr Asn 
    1055                 1060                 1065             


Leu Lys  Lys Thr Phe Asp Glu  Asn Ala Lys Lys Tyr  Glu 
    1070                 1075                 1080     


<210>  1535
<211>  1081
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1535

Met Gln Ala Gln Ser Leu Phe Asp Glu Tyr Lys His Leu Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Val Met Ser Ile Met Asn Ile Ile Thr Val Leu Asn His Ile 
            20                  25                  30          


His Gln Ile Ala Gly Leu Lys Arg Asn Glu Leu Gly Asp Asp Asp Asn 
        35                  40                  45              


Ile Tyr Ser His Pro Val Leu Lys Tyr Ile Ala Pro Glu Asn Asn Ser 
    50                  55                  60                  


Thr Thr Leu Pro Glu Lys Arg Asp Leu Ile Lys Glu Leu Leu Leu Glu 
65                  70                  75                  80  


Tyr Leu Pro Phe Leu Glu Ala Met Lys Asp Cys Tyr Lys Glu Val Lys 
                85                  90                  95      


Val Glu Lys Asp Lys Arg Asn Asn Lys Tyr Val Lys Asp Lys Lys Gln 
            100                 105                 110         


Val Phe Ile Arg Asn Tyr Ser Asp Ile Tyr Cys Ile Tyr Trp Thr Leu 
        115                 120                 125             


Tyr Asn Ile Phe Ser Thr Leu Ile Asn Tyr Arg Asp Lys Ser Cys His 
    130                 135                 140                 


Tyr Arg Phe Ile Pro Ser Lys Asp Gln Glu Glu Tyr Ser Lys Arg Thr 
145                 150                 155                 160 


Glu Tyr Asp Thr Val Arg Ile Ile Asn Lys Tyr Tyr Thr Tyr Ala Leu 
                165                 170                 175     


Arg Lys Thr Lys Glu Lys Tyr Gly Tyr Thr Thr Glu Gln Leu Ser Phe 
            180                 185                 190         


Ile Gln Asn Asn Arg Tyr Thr Asp Asp Lys Lys Val Asn Phe Asn Phe 
        195                 200                 205             


Phe Leu Ser Met Gln Ser Ser Asn Asn Asn Leu Ser His Val Gly Val 
    210                 215                 220                 


Ala Gln Leu Ile Cys Leu Phe Leu Gln Lys Lys Asp Val Asp Asn Phe 
225                 230                 235                 240 


Leu Glu Asn Leu Pro Ile Tyr Asp Asn Arg Tyr Cys Leu Gly Ile Asp 
                245                 250                 255     


Glu His Met Ile Ile Lys Arg Ser Leu Ala Leu His Ser Ile Lys Leu 
            260                 265                 270         


Pro Lys Glu Arg Leu Asn Ser Glu Lys Lys Asp Met Ala Ile Ala Met 
        275                 280                 285             


Asp Met Leu Asn Glu Leu Lys Arg Cys Pro Lys Glu Leu Phe Asn Thr 
    290                 295                 300                 


Leu Pro Phe Asp Lys Gln Glu Arg Phe Arg Ile Ile Ser Ser Asp His 
305                 310                 315                 320 


Lys Glu Val Leu Leu Met Arg Ser Thr Asp Arg Phe Val Pro Leu Ile 
                325                 330                 335     


Leu Gln Tyr Ile Asp Cys Asn Lys Lys Phe Lys Asp Ile Arg Phe His 
            340                 345                 350         


Val Asn Met Gly Lys Leu Arg Tyr Leu Phe Ser Pro Asn Lys Leu Cys 
        355                 360                 365             


Ile Asp Asn Gln Glu Arg Val Arg Met Leu Glu His Leu Leu Asn Gly 
    370                 375                 380                 


Tyr Gly Arg Ile Asp Glu Val Glu Tyr Leu Arg Lys Ala Pro Asn Gly 
385                 390                 395                 400 


Thr Phe Gly Asn Thr Asn Ile Pro Ile Lys Gly Phe Gly Glu Ile Glu 
                405                 410                 415     


Arg Asp Ser Ala Asp Ser Asn Asn Tyr Pro Tyr Ile Val Asp Thr His 
            420                 425                 430         


Thr His Tyr Ile Leu Asn Asn Asn Lys Val Glu Phe Cys Phe Cys Glu 
        435                 440                 445             


Asp Ser Lys Asn Lys Asn Val Phe Pro Thr Ile Glu Lys Glu Ile Asn 
    450                 455                 460                 


Gly Lys Trp Tyr Val Glu Lys Thr Ala Pro His Cys Arg Ile Ser Phe 
465                 470                 475                 480 


Phe Glu Ile Pro Ala Met Ala Phe His Met Phe Leu Cys Gly Ser Glu 
                485                 490                 495     


Lys Thr Glu Lys Leu Ile Lys Asp Val Tyr Asn Asn Tyr Ile Ser Leu 
            500                 505                 510         


Phe Asn Ala Leu Lys Asn Gly Ala Leu Thr Glu Glu Asn Tyr Lys Asp 
        515                 520                 525             


Phe Asn Ile Pro Glu Cys Asp Met Pro Lys Lys Ile Leu Asp Phe Leu 
    530                 535                 540                 


Lys Gly Lys Ala Glu Gly Lys Ser Ile Asp Gly Tyr Val Lys Asn Ile 
545                 550                 555                 560 


Leu Lys Lys Glu Leu Lys Asp Thr Arg Lys Arg Ile Glu Gln Ala Pro 
                565                 570                 575     


Ser Glu Lys Asp Gln Met Pro Ser Lys Arg Asn Lys Ile Gly Thr Lys 
            580                 585                 590         


Ser Tyr Lys Arg Val Leu Thr Gly Lys Leu Ala Asp Phe Leu Ala Lys 
        595                 600                 605             


Asp Ile Val Lys Tyr Gln Pro Thr Leu Cys Ala Gly Asp Asp Tyr Gly 
    610                 615                 620                 


Ile Asp Arg Met Thr Gly Met Asn Tyr Arg Ile Met Gln Ala Thr Ile 
625                 630                 635                 640 


Ala Thr Tyr Asn Asp Asp Asp Asp Phe Asp Thr Phe Tyr Asn Val Phe 
                645                 650                 655     


Lys Met Ala Gly Leu Val Asp Gly Asp Glu Arg Lys Asn His Pro Phe 
            660                 665                 670         


Leu Lys Lys Val Leu Leu Ser Lys Pro Gln Asn Thr Val Ala Phe Asn 
        675                 680                 685             


Ile Lys Tyr Leu Lys Glu Lys Glu Ile Tyr Leu Arg Asn Ile Glu Lys 
    690                 695                 700                 


Lys Asn Ile Ile Pro Pro Phe Val Asn Arg Glu Arg Asn Lys Trp Cys 
705                 710                 715                 720 


Glu Arg Asp Cys Glu Tyr Tyr Arg Ile Leu Gly Glu Asn Leu Leu Asp 
                725                 730                 735     


Leu Pro Ile Glu Leu Pro Arg Gln Met Phe Tyr Lys Asp Ile Arg Ala 
            740                 745                 750         


Gln Leu Glu Pro Leu Met Pro Glu Ile Asp Phe Ser Gln Thr Asn Thr 
        755                 760                 765             


Thr Tyr Leu Ile Ala Glu Tyr Leu Lys Arg Val Arg Gly Asp Asp Phe 
    770                 775                 780                 


Gln Glu Phe Tyr Ser Trp Glu Arg Asn Tyr Arg Tyr Ile Asp Phe Leu 
785                 790                 795                 800 


Lys Cys Ile Arg Asp Asp Asn Gly Arg Ile Cys Ala Gln Tyr Thr Thr 
                805                 810                 815     


Thr Glu Glu Arg Glu Ser Leu Trp Glu Asp Ser Lys Asn Arg Thr Ala 
            820                 825                 830         


Glu Tyr Lys Arg Ser Glu Glu Gln Lys Asn Glu Lys Lys Asp Lys Asn 
        835                 840                 845             


Phe Glu Asp Ser Leu Glu Glu Arg Ile Ser Ser Ser His Ile Lys Phe 
    850                 855                 860                 


Gln Asn Thr Glu Lys His Ile Arg Arg Tyr Lys Val Gln Asp Ala Leu 
865                 870                 875                 880 


Leu Phe Met Ile Ala Glu Lys Gln Phe Gly Lys Tyr Leu Asp Asp Ile 
                885                 890                 895     


Lys Ala Lys Asn Phe Lys Leu Lys Asp Ile Met Pro Asp Thr Asp Lys 
            900                 905                 910         


Gly Ile Leu Ser Glu Thr Met Pro Ile Asp Phe Thr Phe Thr Lys Lys 
        915                 920                 925             


Asn Ile Lys Tyr Asn Ile His Ala Lys Asn Leu Lys Phe Lys Glu Tyr 
    930                 935                 940                 


Gly Asp Leu Phe Ile Leu Ala Asn Asp Lys Arg Leu Glu Ser Leu Trp 
945                 950                 955                 960 


Lys Ile Leu Ala Thr Asp Thr Val Asn Lys Glu Glu Ile Ser Glu Glu 
                965                 970                 975     


Phe Ala Lys Tyr Asp Phe Cys Arg Pro Asp Ile Thr Lys Leu Val Leu 
            980                 985                 990         


Asp Phe Glu Lys Asp Val Leu Glu  Lys Tyr Pro Glu Ile  Ile Glu Glu 
        995                 1000                 1005             


Ala Glu  Lys Glu Tyr Lys Lys  Phe Asp Phe Lys Phe  Ile Leu Asp 
    1010                 1015                 1020             


Trp Leu  Ile Asn Lys Lys Lys  Leu Asn Tyr Gly Ile  Arg Asn Lys 
    1025                 1030                 1035             


Leu Leu  Leu Ile Arg Asn Ala  Phe Asn His Asn Ser  Tyr Pro Asp 
    1040                 1045                 1050             


Lys Lys  Tyr Ala Glu Val Arg  Glu Leu Pro Glu Ile  Ala Thr Asn 
    1055                 1060                 1065             


Leu Lys  Lys Thr Phe Asp Glu  Asn Ala Lys Lys Tyr  Glu 
    1070                 1075                 1080     


<210>  1536
<211>  1047
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1536

Met Glu Glu Gln Phe Leu Gln Lys Glu Arg Asn Met Gly Asp Asn Pro 
1               5                   10                  15      


Tyr Tyr Phe Cys His Phe Ile Asn Met Ala His His Asn Val Asn Leu 
            20                  25                  30          


Ile Leu Glu Glu Ile Tyr Asn Ser Val Tyr Glu Lys Tyr Thr Gln Asp 
        35                  40                  45              


Lys Glu Glu Asn Ile Lys Ala Ile Cys Asn Ser Met Ile Ser Lys Ser 
    50                  55                  60                  


Arg Lys Asn Pro Asp Glu Lys Ala Lys Met Met Asn Met Cys Ile Arg 
65                  70                  75                  80  


His Phe Pro Phe Leu Asp Tyr Tyr Lys Glu Lys Asp Gln Asn Ser Asp 
                85                  90                  95      


Val Leu Thr Ile Leu Leu Asn Gln Phe Leu Val Pro Leu His Gly Leu 
            100                 105                 110         


Arg Asn Gln Phe Ser His Tyr Lys His Pro Gln Glu Ala Tyr Cys Ile 
        115                 120                 125             


Ser Gly Phe Asp Leu Leu Phe Glu Gln Ala Lys Thr Gly Ala Gln Met 
    130                 135                 140                 


Arg Met Lys Tyr Ser Asp Glu Asp Ile Ser Lys Val Lys Ser Lys Val 
145                 150                 155                 160 


Val Asn His Asp Ser Ile Leu Thr Glu Arg Gly Ile Leu Phe Phe Ile 
                165                 170                 175     


Cys Leu Phe Leu Asp Lys Arg Asn Ile Tyr Leu Phe Leu Ser Lys Ile 
            180                 185                 190         


Lys Gly Phe Arg Asp Arg Arg Pro Asp Glu Lys Tyr Lys Ser Ala Thr 
        195                 200                 205             


Leu Glu Val Phe Ser Gln Tyr Tyr Cys His Val Pro Tyr Arg Lys Leu 
    210                 215                 220                 


Asp Ser Ser Asp Val Ala Leu Asp Met Leu Asn Glu Leu Asn Arg Cys 
225                 230                 235                 240 


Pro Lys Ala Leu Tyr Asp Val Leu Ser Asp Glu Asp Arg Glu Arg Phe 
                245                 250                 255     


Ile Val Asp Asn Val Glu Asn Ala Asp Asn Arg Asp Glu Ile Ser Asp 
            260                 265                 270         


Glu Asp Asp Glu Glu Met Pro Arg Ser Val Met Lys Arg Ser Asp Asp 
        275                 280                 285             


Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Glu Lys Gln Asn Asn Leu 
    290                 295                 300                 


Asp Glu Ile Ser Phe His Leu Tyr Leu Gly Arg Lys Glu Ala Lys Pro 
305                 310                 315                 320 


Ala His Glu Lys Val Ile Asn Gly Glu Met Arg Thr His Lys Ile Leu 
                325                 330                 335     


Lys Asp Ile His Val Phe Gly Arg Leu Glu Asn Tyr Arg Asn Glu Glu 
            340                 345                 350         


Ile Cys Asn Ala Ile Lys Asn Arg Glu Asp Ile Glu Phe Tyr Ala Pro 
        355                 360                 365             


Ser Tyr Arg Ile Val Glu Asn Arg Ile Gly Leu Leu Leu Arg Arg Gln 
    370                 375                 380                 


Asn Asp Phe Thr Leu Glu Glu Ala Asn Glu Glu Lys Ile Phe Glu Gly 
385                 390                 395                 400 


Asn Leu Cys Pro Asp Val Ile Leu Ser Thr His Glu Leu Gly Ala Leu 
                405                 410                 415     


Phe Phe Tyr Asn Tyr Leu His Lys Lys Gly Trp Ile Glu Ser Ala Pro 
            420                 425                 430         


Tyr Leu Tyr Ile Arg Asn Phe Ile Ser Asp Phe Lys Arg Phe Ile Glu 
        435                 440                 445             


Asp Ile Lys Asn Gly Lys Leu Thr Pro Val Glu Ser Glu Asp Asp Phe 
    450                 455                 460                 


Tyr Leu Ile Lys Lys Lys Lys Arg Asp Glu Thr Lys Asp Asn Asp Lys 
465                 470                 475                 480 


Lys Ser Ile Ala Val Gln Glu Arg Arg Arg Glu Lys Leu Lys Glu Lys 
                485                 490                 495     


Leu Lys Gly Tyr His Leu Glu Pro Asp Trp Ile Pro Asp Ala Cys Arg 
            500                 505                 510         


Glu Tyr Met Leu Gly Tyr Lys Ala Asp Gln Lys Asp Tyr Tyr Thr Lys 
        515                 520                 525             


Gln Arg Phe Cys Ser Met Lys Lys Glu Thr Asp Ser Arg Ile Lys Gln 
    530                 535                 540                 


Ile Glu Ala Ile Arg Lys Arg Glu Asp Asn Ser Ile Ile Arg Gln Thr 
545                 550                 555                 560 


Arg Val Gly Glu Ile Ala Gln Glu Leu Ala Arg Asp Ile Val Phe Leu 
                565                 570                 575     


Ile Pro Pro Tyr Lys Asn Glu Lys Gly Ala Asp Thr Lys Ile Asn Asn 
            580                 585                 590         


Met Glu Phe Asp Val Leu Gln Lys Met Leu Ala Tyr Phe Pro Leu Asn 
        595                 600                 605             


Lys Lys Asp Ile Tyr Pro Phe Leu Lys Asn Ile Arg Asn Trp Asp Lys 
    610                 615                 620                 


His Pro Phe Leu Lys Tyr Thr Leu His Thr Glu His Gln Ser Leu Leu 
625                 630                 635                 640 


Asp Phe Tyr Gln Asp Tyr Leu Asn Cys Lys Lys Arg Trp Ile Ser Lys 
                645                 650                 655     


Asn Ile Arg Tyr Asp Lys Gln Lys Gly Asn Tyr Leu Val Asp Ala Asn 
            660                 665                 670         


Lys Thr Glu Gln Glu Cys Arg Tyr Phe Leu Lys Thr Asp Lys Leu Arg 
        675                 680                 685             


Thr Ala Lys Glu Lys Glu Tyr Phe Glu Glu Pro Asp Lys Pro Val Tyr 
    690                 695                 700                 


Leu Pro Thr Gly Phe Phe Val Asp Pro Ile Val Glu Ala Met Arg Lys 
705                 710                 715                 720 


Asn Gly Tyr Glu Leu Lys Glu Asn Ser Asn Ile Val Gly Cys Leu Lys 
                725                 730                 735     


Ile Tyr Phe Val Ser Lys Ile Gln Pro Met Tyr Asp Leu Ser Arg Tyr 
            740                 745                 750         


Tyr Thr Tyr Tyr Asp Gly Lys Glu Glu Arg Ser Met Gln Leu Asp Asp 
        755                 760                 765             


Leu Lys Val Phe Ile Lys Glu Lys Phe Gly Asn Lys Arg Thr Asp Asp 
    770                 775                 780                 


Asn Thr Ile Arg Phe Leu Lys Lys Ala Ala Lys Arg Ile Arg Glu Asn 
785                 790                 795                 800 


Glu Ser Glu Ile Leu Val Arg Gln Met Asp Asp Cys Ala Leu Phe Leu 
                805                 810                 815     


Met Val Asn Asp Leu Leu Glu Gly Gly Lys Phe Asn Asp Glu Asp Ile 
            820                 825                 830         


Glu Asn Ile Gly Tyr Asn Lys His His Asn Leu Leu Asp His Glu Tyr 
        835                 840                 845             


Asp Met Cys Glu Thr Ile Tyr Gly Arg Lys Val Thr Ala Arg Leu Pro 
    850                 855                 860                 


Ile Lys Arg Tyr Gly Glu Phe Arg Arg Phe Met Lys Asp Arg Arg Leu 
865                 870                 875                 880 


Gln Asn Leu Val Lys Tyr Tyr Pro Gly Asp His Glu Thr Pro Ile Pro 
                885                 890                 895     


Ser Gly Ile Pro Glu Ser Gly Lys Ala Met Glu Lys Asn Lys Lys Tyr 
            900                 905                 910         


Thr Tyr Ser Asn Leu Cys Asp Glu Leu Glu Ile Tyr Asp Lys Glu Arg 
        915                 920                 925             


Asp Asn Val Leu Asn Leu Ile Tyr Glu Val Asp Lys Ile Leu Val Asp 
    930                 935                 940                 


His Phe Pro Asp Lys Ile Met Lys Glu Glu Asp Gly Tyr Tyr Glu His 
945                 950                 955                 960 


Tyr His Cys Leu Asp Phe Ala Lys Lys Glu Phe Gly Leu Glu Ser Asp 
                965                 970                 975     


Val Glu Leu Leu Ser Gln Asp Asn Phe Lys Asp Leu Arg Asn Ala Leu 
            980                 985                 990         


Tyr His Asn Gln Ile Pro Tyr Asn  Asp Trp Val Ala Asp  Lys Ile Ser 
        995                 1000                 1005             


Lys Asp  Thr Glu Glu Pro Met  Tyr Val Arg Arg Ile  Phe Ser Phe 
    1010                 1015                 1020             


Ile Arg  Thr Val Tyr Ser Arg  Leu Leu Asp Gln Ile  Lys Ile Lys 
    1025                 1030                 1035             


Ile Glu  Lys Asp Glu Tyr Lys  Cys Lys 
    1040                 1045         


<210>  1537
<211>  1140
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1537

Met Glu Asn Asp Gln Gln Ile Leu Glu Asn Arg Arg Arg Thr Leu Ala 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Ser Asn His Leu Ala Thr Ser Phe Glu Gln Lys Ala 
        35                  40                  45              


Leu His Glu Glu Gly Gln Ile Pro Ala Ser Phe Leu Cys Asn Lys Ser 
    50                  55                  60                  


Ile Lys Lys Ile Asn Trp Asn His Val Tyr Ser Lys Ala Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Ile Phe Asp Ala Asp Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Arg Glu Thr Ser Asp Lys Glu Gly Lys Asp Phe Thr Ala Met Asn Glu 
            100                 105                 110         


Thr Leu Lys Leu Val Phe Asp Glu Leu Gln Ala Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Ala Asp Ser Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Val Glu Leu Ala Asp Phe Leu Thr Val Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Ala Asp Asp Asp Tyr 
                165                 170                 175     


Ala Val Val Glu Ser Lys Gln Ile Val Thr Pro Asp Asn Gln Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Ile Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Val Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Leu Ala Tyr Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asp Leu Arg Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Glu 
            260                 265                 270         


Val Ile Thr Glu Glu Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Glu Glu Glu Arg 
    290                 295                 300                 


Glu Lys Ile Leu Asp Glu Ile Asp Tyr Glu Asp Tyr Ile Glu Ser Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg His Ser Asn Arg Phe Pro Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Glu Lys Tyr Asn Lys Gln Phe Asp Gly Glu 
        355                 360                 365             


Ala Thr Glu Arg Lys Val Val Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asn Gln Glu Thr Val Glu Leu Lys Ile Asp Ser Ala 
385                 390                 395                 400 


Gln Arg Thr Asn Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Glu Ala Arg Leu Leu 
            420                 425                 430         


Thr Lys Ala Lys Pro Glu Ser Lys Val Ser Tyr Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Lys Ala Glu Glu Met Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Lys Val Asn Asp Ser Gln Leu Met Asn Met Gln Phe Ile Asp Glu 
                485                 490                 495     


Ile Lys Glu Gln Leu Pro Ala Asp Trp Asn Glu Phe Gly Lys Arg Ser 
            500                 505                 510         


Asp Ser Lys Lys Lys Lys Ala Tyr Thr Asn Ala Ala Arg Gln Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Lys Val Leu Ala Asn Tyr Gln Leu 
    530                 535                 540                 


Asn Asp Lys Gln Val Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Val 
545                 550                 555                 560 


Lys Glu Val Asp Asp Ser Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Met Glu Lys His Lys Val 
            580                 585                 590         


Asp Lys Ser Ala Arg Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Thr Asp Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Tyr 
625                 630                 635                 640 


Ala Asp Asn Glu Lys Lys Ala Thr Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Lys Asp Gly His Pro Phe Leu Ala Asn Ile Asn 
            660                 665                 670         


Leu Arg Gln Ile Arg Lys Thr Ser Gln Leu Tyr Glu Leu Tyr Leu Val 
        675                 680                 685             


Glu Lys Ala Asn Lys Gln Val Lys Lys Met Asn Pro Lys Thr Gln Arg 
    690                 695                 700                 


Thr Asn Asn Val Asp Glu Ser Trp Met Met Lys Ser Phe Tyr Ala Lys 
705                 710                 715                 720 


Glu Trp Asn Glu Glu Met Gly Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Thr Asn Ile Pro Phe Thr Ile Arg Gln Trp Glu Glu Lys 
            740                 745                 750         


Glu Lys His Asn Leu Gln Ala Trp Leu His Asn Ile Thr Lys Gly Lys 
        755                 760                 765             


Thr Ser Lys Asp Gly Lys Lys Ala Val Asp Leu Pro Thr Asn Leu Phe 
    770                 775                 780                 


Asp Asp Thr Leu Cys Glu Leu Leu Arg Glu Ala Leu Ile Asn Glu Gly 
785                 790                 795                 800 


Ile Asp Ala Thr Pro Thr Thr Lys Tyr Asn Glu Leu Leu Lys His Trp 
                805                 810                 815     


Trp Thr Ala Arg Glu Asp Ser Thr Gln Asp Phe Tyr Leu Ser Glu Arg 
            820                 825                 830         


Gln Tyr Asp Ile Tyr Asp Glu Lys Val Cys Phe Thr Ile Asn Ser Ser 
        835                 840                 845             


Ala His Phe Ala Asp Tyr Tyr Ala Pro Ala Leu Ser Lys Ala Tyr Ser 
    850                 855                 860                 


Arg Leu Arg Ala Glu Arg Asp Val Ala Arg Arg Thr Asp Lys Arg Leu 
865                 870                 875                 880 


Pro Pro Val Glu Arg Lys Asp Val Glu Arg Val Phe Lys Asn Thr Ile 
                885                 890                 895     


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
            900                 905                 910         


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asn Gln Gln Gln Leu Lys 
        915                 920                 925             


Leu Ser Lys Met Asp Ser Leu Leu Asn Glu Thr Lys Arg Ile Glu Gln 
    930                 935                 940                 


Val Ile Asn Thr Gln Leu Ser Phe Asp Gln Lys Gly Lys Glu Ile Lys 
945                 950                 955                 960 


Asp Lys Thr Asn Leu Glu Ile Val Lys Thr Ile Val Ala Glu Arg Lys 
                965                 970                 975     


Gln Lys Asn Tyr Thr Glu Met Arg Lys Tyr Val His Asp Arg Arg Leu 
            980                 985                 990         


Pro Glu Leu Phe Glu Tyr Ile Asp  Gly Asn Glu Leu Pro  Leu Asp Met 
        995                 1000                 1005             


Leu Leu  Asn Glu Leu Arg Ala  Tyr Asn Thr Ala Lys  Gln Val Val 
    1010                 1015                 1020             


Phe Asp  Thr Val Phe Ala Leu  Glu Lys Lys Ile Ile  Glu Thr Asp 
    1025                 1030                 1035             


Pro Glu  Gly Leu Lys Gln Leu  Asn Val Ser Lys Asp  Gly Gln Ile 
    1040                 1045                 1050             


Gln Thr  Gly Asn Ile Gln His  Lys Pro Tyr Val Gln  Trp Leu Glu 
    1055                 1060                 1065             


Asn Lys  Gly Leu Ile Thr Asp  Lys Asp Lys Gln Phe  Ile Asn Met 
    1070                 1075                 1080             


Val Arg  Asn Ser Phe Ser His  Asn Gln Phe Pro Gln  Arg Ser Thr 
    1085                 1090                 1095             


Val Glu  Leu Leu Met Pro Val  Trp Gln Asn Thr Asn  Ile Ala Leu 
    1100                 1105                 1110             


Gln Ile  Ala Arg Glu Tyr Gln  Gln Leu Ile Val Asp  Ile Ile Glu 
    1115                 1120                 1125             


Lys Ser  Leu His Pro His Lys  Gln His Gln Met Val  
    1130                 1135                 1140 


<210>  1538
<211>  1094
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1538

Met Glu Ala Asn Glu Gln Asn Gln Glu Asn Arg Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Asn Asn His Ile Ala Ala Asp Phe Gly Gln Ala Val 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ser Gly Phe Leu Cys Asn Lys Glu 
    50                  55                  60                  


Ile Lys Lys Leu Asn Trp Asn His Ile Tyr Ala Lys Thr Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ile Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Val Asn Ser Asp Lys Glu Gly Lys Asp Phe Ala Ala Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Ser Glu Leu Gln Asp Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Glu Asn Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Ala Glu Leu Thr Asp Met Leu Thr Ile Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Thr Asp Ala Asp Tyr 
                165                 170                 175     


Glu Leu Val Glu Thr Lys Gln Val Val Thr Thr Gly Asn Ile Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Met Phe Leu Glu Arg Glu His 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asn Leu Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Gly 
            260                 265                 270         


Val Ile Thr Asp Glu Glu Lys Met Gln Phe Arg Pro Glu Leu Asp Glu 
        275                 280                 285             


Leu Asp Ile Glu Lys Leu Ile Ala Asn Ser Thr Asn Asp Asp Glu Arg 
    290                 295                 300                 


Glu Arg Ile Leu Asp Glu Ile Gly Tyr Glu Glu Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg Tyr Asn Asn Arg Phe Pro Tyr Phe Ala Met Arg 
                325                 330                 335     


Phe Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Arg Tyr Thr Lys Gln Leu Ala Gly Glu 
        355                 360                 365             


Gln Thr Glu Arg Val Val Gln Glu Asn Val Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asp Pro Glu Leu Ile Gln Gln Lys Ile Asp Asn Gln 
385                 390                 395                 400 


Gln Arg Thr Asp Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Ile Ala Ile Leu Ile 
            420                 425                 430         


Pro Lys Ser Lys Pro Glu Ser Lys Val Gly Asn Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Asp Tyr Leu Gln Lys Gly Lys Ala Glu Glu Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Ile Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Leu Lys Leu Pro Ala Asn Trp Asn Glu Phe Ala Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asp Ala Ala Met Glu Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Asp Val Leu Ile Thr Tyr Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Asp Val Glu Asp Asn Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Leu Glu Lys His Lys Leu 
            580                 585                 590         


Asp Lys Ser Val Lys Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Met Val Ser Lys Glu Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Ala Asp Thr Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Val Leu Glu Gly Asp Gly His Pro Phe Leu Thr Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Glu Leu Tyr Met Asn 
        675                 680                 685             


Ala Lys Val Gln Tyr Leu Ile Gln Phe Tyr Lys Pro Ser Lys Asp Lys 
    690                 695                 700                 


Val Asp Lys Arg Gly Arg Pro Thr Thr Glu Val Lys Leu Pro Pro Leu 
705                 710                 715                 720 


Asp Lys Arg Ser Asn Ile Pro Phe Thr Ile Arg Gln Trp Asp Glu Lys 
                725                 730                 735     


Glu Lys Tyr Asn Leu Asn Ala Trp Leu Arg Asn Val Thr Val Gly Lys 
            740                 745                 750         


Asn Thr Lys Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe 
        755                 760                 765             


Asp Glu Thr Leu Cys Asp Leu Leu Ser Gln Gln Leu Asp Ala Arg Thr 
    770                 775                 780                 


Val Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Leu Trp 
785                 790                 795                 800 


Trp Lys Thr Arg Asp Asp Ala Thr Gln Asp Phe Tyr Gln Ser Glu Arg 
                805                 810                 815     


Glu Tyr Asp Ile Tyr Glu Glu Lys Val Glu Phe Lys Ile Asp Ser Ser 
            820                 825                 830         


Gly His Phe Ala Asp Tyr Tyr Lys Lys Ala Leu Ser Lys Ala Tyr Asn 
        835                 840                 845             


Arg Leu Lys Ala Glu Arg Glu Ile Ala Arg Arg Thr Asn Lys Arg Leu 
    850                 855                 860                 


Pro Pro Ile Glu His Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile 
865                 870                 875                 880 


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
                885                 890                 895     


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asp Ser Gly Asn Leu Lys 
            900                 905                 910         


Leu Ser Thr Ile Lys Thr Ser Leu Asn Asn Thr Thr Gln Ile Lys Gln 
        915                 920                 925             


Lys Ile Leu Asn Lys Thr Ile Val Ala Glu Arg Lys Gln Lys Asn Tyr 
    930                 935                 940                 


Thr Glu Leu Arg Lys Tyr Val His Asp Arg Arg Leu Pro Asn Leu Phe 
945                 950                 955                 960 


Glu Tyr Val Glu Ala Asp Glu Ile Leu Leu Glu Trp Leu Leu Asp Glu 
                965                 970                 975     


Leu Met Ala Tyr Asn Ala Ala Lys Gln Gln Val Phe Asp Thr Ile Phe 
            980                 985                 990         


Met Leu Glu Lys Arg Ile Ile Glu  Thr Asp Pro Gln Glu  Leu Lys Ser 
        995                 1000                 1005             


Leu Phe  Thr Asn Glu Lys Gly  Gln Val Gln Thr Gly  Asn Ile Gln 
    1010                 1015                 1020             


His Lys  Pro Tyr Val Gln Trp  Leu Lys Asn Lys Gly  Leu Ile Asn 
    1025                 1030                 1035             


His Asn  Glu Lys Leu Phe Ile  Asn Met Val Arg Asn  Cys Phe Ser 
    1040                 1045                 1050             


His Asn  Gln Phe Pro Gln Arg  Glu Thr Met Glu Leu  Leu Ile Ser 
    1055                 1060                 1065             


Glu Trp  Gly Ala Gly Lys Ile  Ala Thr Gln Ile Leu  Thr Val Tyr 
    1070                 1075                 1080             


Asn Gln  Leu Ile Thr Asn Ile  Ile Asn Lys Ile 
    1085                 1090                 


<210>  1539
<211>  1081
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1539

Met Gln Ala Gln Ser Leu Phe Asp Glu Tyr Lys His Leu Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Val Met Ser Ile Met Asn Ile Ile Thr Val Leu Asn His Ile 
            20                  25                  30          


His Gln Ile Ala Gly Leu Lys Arg Asn Glu Leu Gly Asp Asp Asp Asn 
        35                  40                  45              


Ile Tyr Ser His Pro Val Leu Lys Tyr Ile Ala Pro Glu Asn Asn Ser 
    50                  55                  60                  


Thr Thr Leu Pro Glu Lys Arg Asp Leu Ile Lys Glu Leu Leu Leu Glu 
65                  70                  75                  80  


Tyr Leu Pro Phe Leu Glu Ala Met Lys Asp Cys Tyr Lys Glu Val Lys 
                85                  90                  95      


Val Glu Lys Asp Lys Arg Asn Asn Lys Tyr Val Lys Asp Lys Lys Gln 
            100                 105                 110         


Val Phe Ile Arg Asn Tyr Ser Asp Ile Tyr Cys Ile Tyr Trp Thr Leu 
        115                 120                 125             


Tyr Asn Ile Phe Ser Thr Leu Ile Asn Tyr Arg Asp Lys Ser Cys His 
    130                 135                 140                 


Tyr Arg Phe Ile Pro Ser Lys Asp Gln Glu Glu Tyr Ser Lys Arg Thr 
145                 150                 155                 160 


Glu Tyr Asp Thr Val Arg Ile Ile Asn Lys Tyr Tyr Thr Tyr Ala Leu 
                165                 170                 175     


Arg Lys Thr Lys Glu Lys Tyr Gly Tyr Thr Thr Glu Gln Leu Ser Phe 
            180                 185                 190         


Ile Gln Asn Asn Arg Tyr Thr Asp Asp Lys Lys Val Asn Phe Asn Phe 
        195                 200                 205             


Phe Leu Ser Met Gln Ser Ser Asn Asn Asn Leu Ser His Val Gly Val 
    210                 215                 220                 


Ala Gln Leu Ile Cys Leu Phe Leu Gln Lys Lys Asp Val Asp Asn Phe 
225                 230                 235                 240 


Leu Glu Asn Leu Pro Ile Tyr Asp Asn Arg Tyr Cys Leu Gly Ile Asp 
                245                 250                 255     


Glu His Met Ile Ile Lys Arg Ser Leu Ala Leu His Ser Ile Lys Leu 
            260                 265                 270         


Pro Lys Glu Arg Leu Asn Ser Glu Lys Lys Asp Met Ala Ile Ala Met 
        275                 280                 285             


Asp Met Leu Asn Glu Leu Lys Arg Cys Pro Lys Glu Leu Phe Asn Thr 
    290                 295                 300                 


Leu Pro Phe Asp Lys Gln Glu Arg Phe Arg Ile Ile Ser Ser Asp His 
305                 310                 315                 320 


Lys Glu Val Leu Leu Met Arg Ser Thr Asp Arg Phe Val Pro Leu Ile 
                325                 330                 335     


Leu Gln Tyr Ile Asp Cys Asn Lys Lys Phe Lys Asp Ile Arg Phe His 
            340                 345                 350         


Val Asn Met Gly Lys Leu Arg Tyr Leu Phe Ser Pro Asn Lys Leu Cys 
        355                 360                 365             


Ile Asp Asn Gln Glu Arg Val Arg Met Leu Glu His Leu Leu Asn Gly 
    370                 375                 380                 


Tyr Gly Arg Ile Asp Glu Val Glu Tyr Leu Arg Lys Ala Pro Asn Gly 
385                 390                 395                 400 


Thr Phe Gly Asn Thr Asn Ile Pro Ile Lys Gly Phe Gly Glu Ile Glu 
                405                 410                 415     


Arg Asp Ser Ala Asp Ser Asn Asn Tyr Pro Tyr Ile Val Asp Thr His 
            420                 425                 430         


Thr His Tyr Ile Leu Asn Asn Asn Lys Val Glu Phe Cys Phe Cys Glu 
        435                 440                 445             


Asp Ser Lys Asn Lys Asn Val Phe Pro Thr Ile Glu Lys Glu Ile Asn 
    450                 455                 460                 


Gly Lys Trp Tyr Val Glu Lys Thr Ala Pro His Cys Arg Ile Ser Phe 
465                 470                 475                 480 


Phe Glu Ile Pro Ala Met Ala Phe His Met Phe Leu Cys Gly Ser Glu 
                485                 490                 495     


Lys Thr Glu Lys Leu Ile Lys Asp Val Tyr Asn Asn Tyr Ile Ser Leu 
            500                 505                 510         


Phe Asn Ala Leu Lys Asn Gly Ala Leu Thr Glu Glu Asn Tyr Lys Asp 
        515                 520                 525             


Phe Asn Ile Pro Glu Cys Asp Met Pro Lys Lys Ile Leu Asp Phe Leu 
    530                 535                 540                 


Lys Gly Lys Ala Glu Gly Lys Ser Ile Asp Gly Tyr Val Lys Asn Ile 
545                 550                 555                 560 


Leu Lys Lys Glu Leu Lys Asp Thr Arg Lys Arg Ile Glu Gln Ala Pro 
                565                 570                 575     


Ser Glu Lys Asp Gln Met Pro Ser Lys Arg Asn Lys Ile Gly Thr Lys 
            580                 585                 590         


Ser Tyr Lys Arg Val Leu Thr Gly Lys Leu Ala Asp Phe Leu Ala Lys 
        595                 600                 605             


Asp Ile Val Lys Tyr Gln Pro Thr Leu Cys Ala Gly Asp Asp Tyr Gly 
    610                 615                 620                 


Ile Asp Arg Met Thr Gly Met Asn Tyr Arg Ile Met Gln Ala Thr Ile 
625                 630                 635                 640 


Ala Thr Tyr Asn Asp Asp Asp Asp Phe Asp Thr Phe Tyr Asn Val Phe 
                645                 650                 655     


Lys Met Ala Gly Leu Val Asp Gly Asp Glu Arg Lys Asn His Pro Phe 
            660                 665                 670         


Leu Lys Lys Val Leu Leu Ser Lys Pro Gln Asn Thr Val Ala Phe Asn 
        675                 680                 685             


Ile Lys Tyr Leu Lys Glu Lys Glu Ile Tyr Leu Arg Asn Ile Glu Lys 
    690                 695                 700                 


Lys Asn Ile Ile Pro Pro Phe Val Asn Arg Glu Arg Asn Lys Trp Cys 
705                 710                 715                 720 


Glu Arg Asp Cys Glu Tyr Tyr Arg Ile Leu Gly Glu Asn Leu Leu Asp 
                725                 730                 735     


Leu Pro Ile Glu Leu Pro Arg Gln Met Phe Tyr Lys Asp Ile Arg Ala 
            740                 745                 750         


Gln Leu Glu Pro Leu Met Pro Glu Ile Asp Phe Ser Gln Thr Asn Thr 
        755                 760                 765             


Thr Tyr Leu Ile Ala Glu Tyr Leu Lys Arg Val Arg Gly Asp Asp Phe 
    770                 775                 780                 


Gln Glu Phe Tyr Ser Trp Glu Arg Asn Tyr Arg Tyr Ile Asp Phe Leu 
785                 790                 795                 800 


Lys Cys Ile Arg Asp Asp Asn Gly Arg Ile Cys Ala Gln Tyr Thr Thr 
                805                 810                 815     


Thr Glu Glu Arg Glu Ser Leu Trp Glu Asp Ser Lys Asn Arg Thr Ala 
            820                 825                 830         


Glu Tyr Lys Arg Ser Glu Glu Gln Lys Asn Glu Lys Lys Asp Lys Asn 
        835                 840                 845             


Phe Glu Asp Ser Leu Glu Glu Arg Ile Ser Ser Ser His Ile Lys Phe 
    850                 855                 860                 


Gln Asn Thr Glu Lys His Ile Arg Arg Tyr Lys Val Gln Asp Ala Leu 
865                 870                 875                 880 


Leu Phe Met Ile Ala Glu Lys Gln Phe Gly Lys Tyr Leu Asp Asp Ile 
                885                 890                 895     


Lys Ala Lys Asn Phe Lys Leu Lys Asp Ile Met Pro Asp Thr Asp Lys 
            900                 905                 910         


Gly Ile Leu Ser Glu Thr Met Pro Ile Asp Phe Thr Phe Thr Lys Lys 
        915                 920                 925             


Asn Ile Lys Tyr Asn Ile His Ala Lys Asn Leu Lys Phe Lys Glu Tyr 
    930                 935                 940                 


Gly Asp Leu Phe Ile Leu Ala Asn Asp Lys Arg Leu Glu Ser Leu Trp 
945                 950                 955                 960 


Lys Ile Leu Ala Thr Asp Thr Val Asn Lys Glu Glu Ile Ser Glu Glu 
                965                 970                 975     


Phe Ala Lys Tyr Asp Phe Cys Arg Pro Asp Ile Thr Lys Leu Val Leu 
            980                 985                 990         


Asp Phe Glu Lys Asp Val Leu Glu  Lys Tyr Pro Glu Ile  Ile Glu Glu 
        995                 1000                 1005             


Ala Glu  Lys Glu Tyr Lys Lys  Phe Asp Phe Lys Phe  Ile Leu Asp 
    1010                 1015                 1020             


Trp Leu  Ile Asn Lys Lys Lys  Leu Asn Tyr Gly Ile  Arg Asn Lys 
    1025                 1030                 1035             


Leu Leu  Leu Ile Arg Asn Ala  Phe Asn His Asn Ser  Tyr Pro Asp 
    1040                 1045                 1050             


Lys Lys  Tyr Ala Glu Val Arg  Glu Leu Pro Glu Ile  Ala Thr Asn 
    1055                 1060                 1065             


Leu Lys  Lys Thr Phe Asp Glu  Asn Ala Lys Lys Tyr  Glu 
    1070                 1075                 1080     


<210>  1540
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1540

Met Glu Thr Lys Gln Gln Val Gly Lys Gly Ile Ser Tyr Asp His Arg 
1               5                   10                  15      


Arg Pro Asp Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asp Gly Val Ile Gln Glu Phe Ala Met Arg Leu Asn Arg 
        35                  40                  45              


Glu Tyr Asp Pro Glu Asn Lys Asn Gln Ser Leu Phe Ser Tyr Phe Asn 
    50                  55                  60                  


Ile Asn Ala Ser Phe Thr Asp Trp Glu Arg Gly Val Asn Ile Leu Lys 
65                  70                  75                  80  


Glu Tyr Trp Pro Met Met Glu Phe Ile Asp Arg Pro Ala Thr Asp Lys 
                85                  90                  95      


Gln Phe Glu Ala Glu Lys Pro Glu Asn Arg Glu Ala Ala Lys Arg Lys 
            100                 105                 110         


Tyr Phe Leu Ala Thr Leu Gly Ala Leu Leu Thr Ser Ile Lys Asp Leu 
        115                 120                 125             


Arg His Tyr Tyr Thr His Tyr Tyr His Pro Pro Val His Leu Asn Asp 
    130                 135                 140                 


Asp Leu Phe Leu Phe Leu Asp His Ala Leu Leu Tyr Thr Ala Phe Asp 
145                 150                 155                 160 


Val Lys Lys Thr Lys Met Lys Asp Asp Lys Thr Arg Gln Leu Leu Asn 
                165                 170                 175     


Gln Asn Leu Ser Leu Glu Leu Glu Lys Leu Lys Lys Leu Lys Val Glu 
            180                 185                 190         


Glu Leu Lys Lys Lys Lys Glu Lys Gly Ile Lys Val Asn Leu Gln Asp 
        195                 200                 205             


Glu Lys Gly Ile Leu Asn Ala Ile Tyr Asn Asp Ala Phe Ala His Ile 
    210                 215                 220                 


Ile Thr Lys Glu Lys Asp Ser Asp Lys Asp Lys Leu Glu Thr Arg Tyr 
225                 230                 235                 240 


Lys Ser Ile Leu Pro Gln Asp Glu Ala Ala Glu Thr Gly Ile Asn Ile 
                245                 250                 255     


Ser Ile Ser Gly Leu Ile Phe Leu Leu Ser Leu Phe Leu Ser Arg Lys 
            260                 265                 270         


Glu Ile Glu Gln Leu Lys Ser Asn Ile Glu Gly Tyr Lys Gly Lys Val 
        275                 280                 285             


Leu Asn Ile Glu Thr Glu Val Asp Arg Lys His Asn Ser Leu Lys Tyr 
    290                 295                 300                 


Met Ala Thr His Trp Val Phe Ser Ile Leu Ala Phe Lys Gly Leu Lys 
305                 310                 315                 320 


Gln Arg Leu Thr Asn Ser Phe Glu Lys Glu Ser Leu Leu Ile Gln Met 
                325                 330                 335     


Met Asp Glu Leu Asn Lys Val Pro Asp Glu Leu Tyr Gln Thr Leu Ser 
            340                 345                 350         


Glu Thr Ala Lys Lys Glu Phe Leu Glu Asp Ile Asn Glu Tyr Val Ser 
        355                 360                 365             


Glu Gly Asp Asp Asn Glu Lys Ala Thr Tyr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Ser Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gln Phe Pro Thr Leu Lys Phe Gln Ile Phe Val Gly 
                405                 410                 415     


Gln Tyr Leu His Asp Asn Arg Pro Lys Thr Leu Ala Ser Asn Gly Met 
            420                 425                 430         


Thr Ala Gln Arg Met Ile Lys Glu Lys Ile Asn Leu Phe Gly Asn Leu 
        435                 440                 445             


Ser Glu Val Thr Lys His Lys Ser Asp Phe Phe Glu Lys Glu Ser Ala 
    450                 455                 460                 


Ala Gln Gly Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Trp Ala Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Val Tyr Ile Asp Met Ile Gly Lys Glu Gly Lys Ala 
                485                 490                 495     


Lys Glu Ile Gln Val Gln Ile Asn Lys Tyr Arg Lys Gln Leu Asn Pro 
            500                 505                 510         


Ala Pro Gln Arg Asp Lys Arg Ile Ser Lys Lys Glu Ile Ile Glu Gln 
        515                 520                 525             


Leu Tyr Lys Glu Lys Val Val Tyr Gly Asp Pro Thr Leu Met Leu Ser 
    530                 535                 540                 


Ala Asn Glu Leu Met Ala Leu Leu Tyr Glu Leu Ile Val Asn Gly Lys 
545                 550                 555                 560 


Ser Gly Ala Glu Leu Glu Asn Lys Ile Val Glu Gln Ile Ile Ala Arg 
                565                 570                 575     


Tyr Glu Gln Ile Glu Ala Tyr Asp Pro Thr Thr Gln Gln Leu Pro Thr 
            580                 585                 590         


Asn Gln Met Pro His Lys Leu Gln Lys Ser Arg Lys Asp Ser Lys Val 
        595                 600                 605             


Thr Asp Thr Asp Lys Leu Leu Lys Thr Ile Asp Lys Glu Ile Asp Glu 
    610                 615                 620                 


Gly Asn Lys Lys Leu Glu Leu Ile Ala Cys His Arg Lys Glu Trp Glu 
625                 630                 635                 640 


Glu Ala Glu Gln Arg Lys Lys Ser Gly Lys Arg Asn Asn Pro Gly Thr 
                645                 650                 655     


Lys Ser Arg Lys His Leu Phe Tyr Ala Ser Glu Met Gly Glu Glu Ala 
            660                 665                 670         


Thr Trp Ile Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Pro Ala Arg 
        675                 680                 685             


Ala Glu Trp Lys Gly Thr His His Ser Glu Leu Gln Arg Leu Leu Ala 
    690                 695                 700                 


Phe Tyr Ser Thr Gln Arg Leu Glu Ala Trp Gln Leu Val Glu Ser Val 
705                 710                 715                 720 


Trp Thr Ala Asn Thr His Ser Phe Trp Glu Glu Asn Phe Lys Glu Ala 
                725                 730                 735     


Phe Tyr Lys Pro Glu Phe Glu Asn Phe Tyr Gly Ala Tyr Ile Glu Ile 
            740                 745                 750         


Arg Thr Lys Ile Leu Thr Thr Cys Arg Ser Ile Leu Glu Asn Asn Pro 
        755                 760                 765             


Glu Ala Thr Met Asn Asn Asp Thr Glu Lys Glu Trp Asp Lys Val Phe 
    770                 775                 780                 


Thr Leu Phe Asp Lys Arg Leu Tyr Arg Thr Ser Thr Thr Asp Glu Gln 
785                 790                 795                 800 


Lys Lys Gln Leu Leu Thr Lys Pro Phe Ala Phe Pro Arg Gly Leu Phe 
                805                 810                 815     


Asp Asp Lys Pro Thr Phe Leu Pro Gly Ser Lys Pro Asn Glu Asn Pro 
            820                 825                 830         


Glu Arg Phe Ala Ala Trp Tyr Ser Tyr Gly Tyr Thr Tyr Ser Gly Lys 
        835                 840                 845             


Phe Gln Ser Phe Tyr Asp Met Pro Arg Asn Tyr Ser Asp Trp Tyr Lys 
    850                 855                 860                 


Lys Leu Lys Glu Asp Gly Lys Leu Pro Arg Leu Asp Lys Lys Thr Glu 
865                 870                 875                 880 


Gln Glu Lys Ile Leu Arg Phe Arg Met Asp Cys Asp Leu Asn Ile Lys 
                885                 890                 895     


His Ile Arg Phe Gln Asp Ile Tyr Val Lys Leu Met Val Asp Ser Leu 
            900                 905                 910         


Tyr Lys Ala Val Phe Gly Gln Gln Pro Glu Phe Asp Leu Ser His Leu 
        915                 920                 925             


Tyr Asp Thr Arg Ser Glu Arg Tyr Glu Asn Asn Thr Ile Ala Gln Arg 
    930                 935                 940                 


Gln Lys Ser Arg Gln Glu Gly Asp Asn Ser Asp Asn Ala Ile Asn Glu 
945                 950                 955                 960 


Asn Tyr Val Trp Asn Lys Thr Phe Ala Ile Ser Leu Tyr Asn Gly Arg 
                965                 970                 975     


Ile Thr Glu Ser Gln Val Lys Leu Lys Asp Val Gly Lys Phe Arg Arg 
            980                 985                 990         


Phe Ala Thr Asp Pro Arg Val Gln  Thr Leu Ile Ser Tyr  Asp Asp Thr 
        995                 1000                 1005             


Arg Thr  Trp Thr Lys Leu Glu  Ile Glu Asn Glu Leu  Asp Asn Lys 
    1010                 1015                 1020             


Ala Asp  Ala Tyr Glu Pro Ile  Arg Arg Thr Gln Ser  Leu Lys Ala 
    1025                 1030                 1035             


Ile Gln  Gln Leu Glu Lys Asn  Ile Leu Lys Lys Asn  Gly Phe Asn 
    1040                 1045                 1050             


Gly Lys  Gln His Pro Glu Glu  Leu Lys His Asn Gly  Asn Pro Asn 
    1055                 1060                 1065             


Phe Arg  Lys Tyr Ile Ala Asn  Gly Leu Leu Lys His  Arg Thr Asp 
    1070                 1075                 1080             


Ile Arg  Gln Glu Glu Leu Ala  Leu Ile Ser Asp Thr  Glu Phe Gln 
    1085                 1090                 1095             


Glu Ile  Gly Leu Glu Arg Ile  Arg Gln Thr Asn Pro  Leu Ile Gln 
    1100                 1105                 1110             


Lys Ala  Tyr Leu Leu Ile Leu  Leu Arg Asn Lys Phe  Gly His Asn 
    1115                 1120                 1125             


Gln Leu  Pro Asp Gln Glu His  Phe Arg Leu Met Arg  Ser Ile Tyr 
    1130                 1135                 1140             


Pro Tyr  Asn Gln Gln Glu Ser  Tyr Ser Ala Tyr Phe  Asn His Val 
    1145                 1150                 1155             


Ile Thr  Gln Ile Ile Glu Glu  Leu Asn Thr 
    1160                 1165             


<210>  1541
<211>  1140
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1541

Met Asn Leu Ser Ile Lys Pro Asn Tyr Arg Lys Tyr Asn Asp Glu Thr 
1               5                   10                  15      


Asp Lys Ala Phe Phe Ala Ser Tyr Leu Asn Thr Ala Lys Gln Asn Val 
            20                  25                  30          


Phe Ile Thr Phe Arg Asp Ile Ser Glu Arg Leu Gly Leu Gly Phe Asp 
        35                  40                  45              


Leu Asn Asp Asp Asp Asn Met Met Asn Ala Gly Leu Trp Lys Lys Leu 
    50                  55                  60                  


Arg Asp Asn Ala Glu Pro Asp Val Ser Trp Lys Ile Ile Gln Lys Ile 
65                  70                  75                  80  


Glu Glu Lys Phe Pro Tyr Ala Asn Tyr Leu Ala Lys Asn Tyr Ala Tyr 
                85                  90                  95      


Phe Lys Arg Lys Glu Arg Gln Ala Lys Pro Glu Asp Tyr Ser Lys Val 
            100                 105                 110         


Phe Ala Ile Phe Ile Gln Gln Leu Tyr Asp Phe Arg Asn Ser Tyr Thr 
        115                 120                 125             


His Ala Val His Asp Pro Val Glu Thr Pro Lys Glu Ile Ile Ala Gly 
    130                 135                 140                 


Met Gln Leu Leu Phe Asp Ala Gly Arg Arg Gly Ile Lys Lys Arg Phe 
145                 150                 155                 160 


Lys Leu Gly Ala Lys Asp Met Met His Leu Val Arg Leu Glu Arg Thr 
                165                 170                 175     


Gly Lys Gly Lys Asp Ala Lys Thr Ile Glu Arg Ser Asp Phe His Tyr 
            180                 185                 190         


Ser Phe Val Asp Asp Lys Asp Lys Leu Ser Glu Lys Gly Leu Ala Tyr 
        195                 200                 205             


Phe Ile Cys Leu Trp Leu Gln Arg Lys Asp Ala Gln Thr Phe Leu Lys 
    210                 215                 220                 


Lys Leu Glu Gly Phe Lys Arg Ser Glu Lys Pro Gly Glu Lys Ala Thr 
225                 230                 235                 240 


Leu Glu Thr Tyr Thr Phe Tyr Ser Leu Arg Leu Pro Gln Pro Lys Leu 
                245                 250                 255     


Lys Ser Asp Asn Asn Ser Ala Gly Leu Leu Leu Asp Met Val Asn Glu 
            260                 265                 270         


Leu Arg Arg Cys Pro Lys His Leu Tyr Pro Leu Leu Ser Glu Asp Asp 
        275                 280                 285             


Lys Glu Arg Phe Leu Lys Lys Ala Glu Glu Ile Glu Thr Glu Asp Glu 
    290                 295                 300                 


Tyr Glu Ala Leu Pro Ile Leu Lys Arg Ser Ser Asn Arg Phe Tyr Tyr 
305                 310                 315                 320 


Phe Ala Leu Lys Tyr Phe Asp Thr Val Phe Lys Asp Ala Lys Phe His 
                325                 330                 335     


Val Asp Leu Gly Asn Tyr Cys Phe His Val Tyr Asn Lys Asp Val Asp 
            340                 345                 350         


Gly Gln Asn Arg Ile Arg Arg Trp Ile Lys Lys Met Thr Ala Phe Gly 
        355                 360                 365             


Asn Leu Asp Asp Phe Ser Asp Glu Lys Arg Pro Gln Gln Trp Ile Asp 
    370                 375                 380                 


Lys Ile Gln Arg Ile Glu Asp Arg Asp Phe Glu Lys Glu Asp Ile Tyr 
385                 390                 395                 400 


Leu Thr Gln Thr Thr Pro His Tyr His Ile Asn Gly Lys Asn Ile Gly 
                405                 410                 415     


Leu Lys Phe Arg His Ser Tyr Ser Glu Leu Val Lys Asp Asn Lys Ile 
            420                 425                 430         


Trp Pro Glu Leu Pro Asp Phe Asp Lys Glu His Ala Lys Thr Thr Leu 
        435                 440                 445             


Pro Arg Thr Lys Ala Pro Asp Cys Trp Leu Ser Leu Tyr Glu Leu Pro 
    450                 455                 460                 


Ala Met Val Phe Tyr His Leu Leu Leu Gln Asp Asn Thr Ala Ser Thr 
465                 470                 475                 480 


Ser Val Glu Glu Ile Ile Arg Leu His Val Lys Ser Met Asp Leu Phe 
                485                 490                 495     


Phe Met Asp Ile Glu Asn Gly Val Leu Asn Pro Gly Met Asn Asn Ser 
            500                 505                 510         


Gly Phe Ala Glu Glu Ile Ser Lys Arg Gly Leu Glu Lys Tyr Phe Ile 
        515                 520                 525             


Pro Lys Pro Leu Ile Glu Tyr Leu Thr Ser Ala Thr Thr Lys Thr Phe 
    530                 535                 540                 


Glu Asp Arg Ala Asp Lys Met Leu Glu Ala Leu Ile Ala Glu Thr Lys 
545                 550                 555                 560 


Gln Met Leu Lys Lys Ile Asn Asn Gln Lys Asp Asn Phe Ala Gln Lys 
                565                 570                 575     


Pro Gly Ser Lys Asp Tyr Val Glu Met Lys Ser Gly Asn Met Ala Asp 
            580                 585                 590         


Phe Leu Ala Arg Asp Ile Ile Arg Leu Gln Lys Pro Leu Ala Gly Met 
        595                 600                 605             


Lys Gly Lys Pro Asn Ser Thr Glu Phe Gln Val Leu Gln Ala Lys Leu 
    610                 615                 620                 


Ala Phe Phe Gly Ala Asn Lys Asp Ser Leu Asp Ala Thr Phe Asn Asn 
625                 630                 635                 640 


Leu Gln Leu Thr Asn Ser Glu Asn Pro His Pro Phe Leu His Gln Ile 
                645                 650                 655     


Arg Val Asp Thr Cys Lys Gly Ile Leu Asp Phe Tyr Val Lys Tyr Leu 
            660                 665                 670         


Lys Lys Arg Glu Trp Tyr Leu Gly Tyr Cys Lys Ser Lys Glu Gln Tyr 
        675                 680                 685             


His Asp Tyr His Phe Leu Lys Met Gly Arg Arg Arg Lys Glu His Ser 
    690                 695                 700                 


Glu Thr Tyr Tyr Lys Asn Leu Ala Asn Glu Leu Arg Thr Gln Asn Val 
705                 710                 715                 720 


Gln Asn Leu Pro Arg Gly Leu Phe Leu Lys Pro Ile Leu Asn Ile Leu 
                725                 730                 735     


Ser Ser Thr Glu Lys Thr Lys Val Leu Ala Gly Glu Leu Lys Gln Leu 
            740                 745                 750         


Ser Arg Val Asn Thr Ala Tyr Ile Ile Glu Lys Tyr Phe Thr Gln Ile 
        755                 760                 765             


Leu Asp Asp Ser Pro Gln Glu Phe Tyr Thr Tyr Asn Arg Ser Tyr Glu 
    770                 775                 780                 


Phe Leu Asn Lys Ile Tyr Asp Asp Arg Lys Lys Asn Gly Met Pro Leu 
785                 790                 795                 800 


Lys Gln Lys Phe Leu Thr Ile Asp Glu Leu Lys Asp Lys Ala Gln Arg 
                805                 810                 815     


Ile Asn Glu Asp Thr Tyr Asp Asn Glu Ile Leu Arg Ala Met Asp Asp 
            820                 825                 830         


Lys Ile Glu Val Glu Ala Lys Lys Thr Lys Arg Asn Gly Lys Arg Leu 
        835                 840                 845             


Ser Lys Asp Glu Ile Asn Glu Leu Lys Glu Lys Tyr Trp Thr Arg Tyr 
    850                 855                 860                 


Lys Ala Phe Gly Glu Asn Glu Lys Gln Ile Arg Leu Ala Lys Thr Cys 
865                 870                 875                 880 


Asp Met Val Leu Phe Met Leu Val Asp His Thr Leu Arg Arg Ser Phe 
                885                 890                 895     


Val Ile Asn Glu Gly Phe Val Lys Lys Lys Lys Glu Thr Asn Asp Ile 
            900                 905                 910         


Lys Pro Val Glu Phe Gly Asn Glu Tyr Lys Leu Ser Gln Ile Lys Ala 
        915                 920                 925             


Glu Ser Asp Lys Gly Ile Leu Glu Leu Gln Thr Glu Ala Lys Ile Glu 
    930                 935                 940                 


Met Pro Tyr Ser Tyr Glu Thr Asn Met Asp Ser Leu Leu Lys Ile Ala 
945                 950                 955                 960 


Gly Ala Lys Ser Lys Leu Ser Asp Leu Gln Ser Lys Thr Ile Leu Arg 
                965                 970                 975     


Glu Gln Ile Lys Ile Lys Asn Tyr Gly Asp Phe Arg Ala Leu Met Lys 
            980                 985                 990         


Asp Arg Arg Ile Ser Ser Leu Leu  Pro Tyr Leu Ala Lys  Asp Pro Ile 
        995                 1000                 1005             


Tyr Phe  Glu Ala Leu Gln Lys  Glu Leu Glu Leu Tyr  Gln Glu Val 
    1010                 1015                 1020             


Arg Val  Glu Val Met Asp Thr  Ile His Asn Phe Glu  Arg Lys Ala 
    1025                 1030                 1035             


Ile Ala  Leu Lys Gly Ile Ile  Lys Gly Ser Asp Lys  Ala Phe Ile 
    1040                 1045                 1050             


Ser His  Glu Gln Ile Leu Asp  Gly Phe Pro Gly Tyr  Asp Pro Ala 
    1055                 1060                 1065             


Lys Arg  Met Lys Ile Glu Lys  Leu Arg Asn Ala Phe  Cys His Ser 
    1070                 1075                 1080             


Gln Tyr  Pro Ala Tyr Leu Leu  Tyr Lys Asp Glu Ile  Asn Gly Asp 
    1085                 1090                 1095             


Gly Ile  Asn Lys Leu Lys Asp  Tyr Thr Ala Asp Glu  Pro Ile Val 
    1100                 1105                 1110             


Leu His  Asn Ser Pro Ala Leu  Gln Phe Lys Lys Ile  Ile Gln Lys 
    1115                 1120                 1125             


Tyr Tyr  Asp Asp Ile Ile Gln  Phe Asp Ile Thr Gly  
    1130                 1135                 1140 


<210>  1542
<211>  1181
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1542

Met Glu Asn Leu Pro Leu Arg Ser Phe Lys Arg Phe Phe Asp Phe Lys 
1               5                   10                  15      


Gly Asn Val Ala Pro Ile Ala Glu Lys Ala Val Arg Asn Phe Thr Leu 
            20                  25                  30          


Lys Lys Glu Asn Pro Asp Asn Leu Lys Gln Arg Leu His Tyr Phe Ala 
        35                  40                  45              


Ile Gly His Thr Phe Lys Asn Ile Asp Thr Lys Asn Ile Phe Glu Tyr 
    50                  55                  60                  


Thr Leu Asn Glu Glu Thr Arg Glu Ser Met Pro Thr Lys Phe Leu Ala 
65                  70                  75                  80  


Leu Gln Gln Asp Asn Phe Thr Ile Asp Lys Asp Leu Glu Lys Leu Pro 
                85                  90                  95      


Ser Asn Ile Arg Asn Lys Asp Leu Gly Ser Leu Leu Ser Asp Ile Arg 
            100                 105                 110         


Asn Ile Asn Ser His Tyr Val His Asp Phe Glu Lys Leu Lys Leu Asp 
        115                 120                 125             


Asn Ile Asp Asp Lys Ile Ile Glu Phe Leu Lys Gln Ser Phe Glu Leu 
    130                 135                 140                 


Ala Leu Ile Asn Thr Ile Leu Lys Glu Lys Glu Ile Ser Tyr Glu Asp 
145                 150                 155                 160 


Phe Ile Ser Asn Glu Ser Glu Lys Glu Ile Val Asp Phe Leu Val Asp 
                165                 170                 175     


Lys Phe Tyr Pro Leu Asn Asp Gln Arg Lys Asp Leu Asp Glu Leu Ala 
            180                 185                 190         


Gln Lys Ser Leu Asp Asn Tyr Ile Glu Phe Arg Asp Asp Phe Lys Asn 
        195                 200                 205             


Lys Thr Lys Asp Asp Ala Ile Asn Ala Ile Leu Phe Val Asn Val Glu 
    210                 215                 220                 


Thr Glu Tyr Glu Trp Lys Ile Tyr Gly Glu His His Ile Phe Asn Ile 
225                 230                 235                 240 


Thr Lys Gly Ser Tyr Leu Ser Phe Glu Ala Cys Leu Phe Leu Leu Ser 
                245                 250                 255     


Met Phe Leu Tyr Lys Gly Glu Ala Asn Thr Leu Ile Ser Lys Ile Lys 
            260                 265                 270         


Gly Phe Lys Arg Asn Asp Asp Asn Lys Tyr Arg Ser Lys Arg Asn Leu 
        275                 280                 285             


Phe Ser Phe Tyr Ser Lys Lys Phe Ser Ser Gln Asp Ile Asn Ser Glu 
    290                 295                 300                 


Glu Asn His Leu Ile Lys Phe Arg Asp Ile Val Gln Tyr Leu Asn His 
305                 310                 315                 320 


Tyr Pro Thr Ile Trp Asn Lys Asp Leu Glu Leu Glu Ser Asn Asn Pro 
                325                 330                 335     


Leu Met Thr Asp Lys Leu Lys Glu Lys Ile Ile Glu Met Glu Val Ala 
            340                 345                 350         


Arg Cys Phe Pro Asp Leu Asn Ser Asp Ile Glu Phe Asn Glu Phe Ala 
        355                 360                 365             


Ile Gln Tyr Leu Phe Tyr Lys Lys Glu Ser Glu Asn His Asn Lys Asn 
    370                 375                 380                 


Leu Tyr Leu Asp Ile Ile Asn Lys Asn Asp Glu Val Arg Lys Ile Tyr 
385                 390                 395                 400 


Tyr Ser Ile Lys Asn Asp Ser Leu Asn Leu Arg Glu Phe Lys Asp Asn 
                405                 410                 415     


Thr Phe Lys Met Tyr Ala Leu Lys Tyr Val Val Asn Lys Tyr Phe Lys 
            420                 425                 430         


Asp Asn Lys Lys Leu Thr Asn Leu Lys His Lys Arg Phe Tyr Gly Lys 
        435                 440                 445             


Lys Glu Arg Glu Phe Lys Asp Glu Leu Ile Thr Asn Asn Lys Thr Glu 
    450                 455                 460                 


Lys Leu Lys Ile Gln Ile Ser Lys Asn Lys Leu Phe Val Ser Tyr Gly 
465                 470                 475                 480 


Arg Asn Gln Glu Arg Phe Ile Asp Phe Ala Met Cys Phe Leu Ala Lys 
                485                 490                 495     


Thr Asn Tyr Phe Gly Lys Asp Ala Glu Phe Lys Ile Tyr Gln Phe Tyr 
            500                 505                 510         


Ser Ser Glu Glu Gln Asn Glu Glu Leu Asn Thr Leu Lys Gln Lys Leu 
        515                 520                 525             


Thr Lys Lys Gln Tyr Asp Lys Leu Lys Tyr His Arg Gly Lys Leu Val 
    530                 535                 540                 


His Phe Ser Thr Phe Glu Asn His Leu Gly Lys Tyr Asp Asn Trp Asp 
545                 550                 555                 560 


Thr Pro Phe Val Ile Glu Asn Asn Ala Val Gln Val Arg Val Thr Phe 
                565                 570                 575     


Leu Ser Gly Ile Gln Lys Ile Val Ser Ile Gln Arg Asn Leu Leu Thr 
            580                 585                 590         


Tyr Phe Leu Glu Asp Ala Leu Phe Asn Tyr Ser Thr Asn Lys Leu Glu 
        595                 600                 605             


Asp Ala Gly Lys Arg Leu Ile Ser Gly Tyr Phe Thr His His Leu Lys 
    610                 615                 620                 


Glu Phe Ser Glu Ser Lys Leu Ile Leu Glu Gln Lys Thr Ser Ile Ser 
625                 630                 635                 640 


Gln Asp Glu Lys Thr Ser Leu Lys Lys Ile Leu Pro Lys Arg Leu Leu 
                645                 650                 655     


His His Tyr Ser Pro Ala Ile Gln Asn Phe Ile Pro Lys Phe Ser Thr 
            660                 665                 670         


Phe Glu Leu Leu Leu Glu Lys Val Lys Ile Gln Glu Asn Arg Tyr Leu 
        675                 680                 685             


Glu Leu Phe Lys Lys Val Glu Gly Glu Glu Met Ile Tyr Lys Lys Ser 
    690                 695                 700                 


Asn Pro His Asp Lys Asn Val Ser Leu Val Lys Asp Phe Leu Lys Arg 
705                 710                 715                 720 


Asn Lys Gly Arg Gln Phe Lys Leu Asn Phe Ile Arg Lys Ala Cys His 
                725                 730                 735     


Leu Met Tyr Phe Lys Glu Ser Tyr Leu Lys Gln Val Glu Val Ser Gly 
            740                 745                 750         


His His Lys Arg Phe His Ile Ser Lys Asp Glu Phe Asn Asp Phe Ser 
        755                 760                 765             


Lys Trp Met Phe Ala Phe Asp Glu Val Pro Ala Tyr Lys Leu Tyr Leu 
    770                 775                 780                 


Ala Glu Leu Phe Glu Ser Lys Gly Phe Phe Asp Asn Pro Glu Phe Lys 
785                 790                 795                 800 


Ser Leu Phe Glu Ser Ser Thr Ser Leu Ser Asn Met Tyr Glu Asn Thr 
                805                 810                 815     


Lys Asp Val Tyr Glu Asn Trp Leu Leu Thr Leu Lys Gln Ser Glu Lys 
            820                 825                 830         


Asp Lys Asp Lys Tyr Lys Leu Ser Asn Tyr Glu Lys Phe Phe Ala Asp 
        835                 840                 845             


Asp Leu Phe Tyr Ile Asn Val Ser His Phe Leu Lys Tyr Leu Glu Ser 
    850                 855                 860                 


Thr Cys Val Ile Ala Arg Asn Glu Gln Gly Asn Ile Ile Tyr Lys Ser 
865                 870                 875                 880 


Leu Glu Asn Glu Lys His Leu Ile Leu Gly Tyr Tyr Tyr Lys Asn Lys 
                885                 890                 895     


Leu Glu Lys Ala Glu Tyr Lys Thr Cys Gly Lys Leu Tyr Asn Lys Leu 
            900                 905                 910         


Lys Ser Ile Lys Leu Glu Asp Ala Leu Leu Phe Glu Leu Ala Met Tyr 
        915                 920                 925             


Tyr Leu Lys Ile Asp Lys Ser Ile Ser Gln Lys Ala Arg Thr Asp Ile 
    930                 935                 940                 


Thr Thr Leu Leu Ser Gln Asp Val Ile Phe Glu Ile Lys Asp Ser Asn 
945                 950                 955                 960 


Ser Asn His Leu Phe Asp Ile Glu Ile Pro Phe Asn Lys Ile Asp Ala 
                965                 970                 975     


Tyr Val Glu Leu Ile Thr Phe Lys Glu Glu Gln Glu Asp Asp Pro Arg 
            980                 985                 990         


Phe Ser Lys Thr Ser Phe Ile Gly  Asn Leu Pro Ala Tyr  Ile Glu Lys 
        995                 1000                 1005             


Val Lys  Asp Asn Lys Asp Ile  Gln Gln Val Tyr Tyr  Asn Tyr Asn 
    1010                 1015                 1020             


Thr Thr  Lys Asn Leu Thr Tyr  Asp Asp Leu Tyr Thr  Ile Asn Asn 
    1025                 1030                 1035             


His Ile  Ile Ser Asn Ser Val  Lys Phe Thr Lys Val  Ala Leu Leu 
    1040                 1045                 1050             


Leu Glu  Lys Tyr Phe Ile Trp  Lys Asp Glu Ile Lys  Ile Lys Asn 
    1055                 1060                 1065             


Gly Tyr  Asn Ile Asp Phe Glu  Asn Val Ile Gly Leu  Lys Asn Tyr 
    1070                 1075                 1080             


Phe Asp  Lys Glu Lys Lys Lys  Asn Glu Ile Ile Arg  Asn Lys Ala 
    1085                 1090                 1095             


Phe His  Phe Gly Val Pro Asp  Lys Ser Tyr Asp Val  Ile Ile Lys 
    1100                 1105                 1110             


Glu Ile  Glu Gln Lys Phe Ile  Lys Glu Glu Val Lys  Pro Thr Thr 
    1115                 1120                 1125             


Pro Ser  Asn Tyr His Asp Leu  Ser Lys Gln Leu Lys  Trp Ile Cys 
    1130                 1135                 1140             


Lys Ala  Phe Leu Asp Thr Ile  His Asn Asp Tyr Phe  Val Asn Gly 
    1145                 1150                 1155             


Lys Gly  Asp Lys Ser Lys Lys  Arg Ala Asp Ala Glu  Asn Lys Tyr 
    1160                 1165                 1170             


Phe Tyr  Lys Val Ile Asn Lys  Thr 
    1175                 1180     


<210>  1543
<211>  1057
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1543

Met Thr Ile Lys Glu Gln Ser His Phe Ala Ala Tyr Tyr Asn Met Ala 
1               5                   10                  15      


Arg His Asn Met Tyr Glu Thr Leu Cys Tyr Ile Ser Lys Ile Ser Gly 
            20                  25                  30          


Ile Gln Glu Gly Glu Asp Asn Lys Glu Ser Lys Ile Glu Asp Met Gln 
        35                  40                  45              


Leu Leu Arg Val Leu Thr Thr Lys Gly His Pro Glu Glu Lys Ile Arg 
    50                  55                  60                  


Ile Glu Lys Leu Ile Tyr Lys His Leu Pro Leu Phe Arg Pro Ala Val 
65                  70                  75                  80  


Glu Asp Leu Arg Lys Lys Ser Lys Glu Asn Val Lys Ser Pro Glu Leu 
                85                  90                  95      


Leu Ala Lys Val Ile Lys Asn Trp Ala Lys Val Ile Thr Tyr Tyr Arg 
            100                 105                 110         


Asp Lys Phe Thr His Tyr Val Phe Ile Asp Lys Arg His Glu Asn Lys 
        115                 120                 125             


Glu Phe Leu Asn Ala Glu Met Ser Val Ala Asn Asp Leu Asn Gln Ile 
    130                 135                 140                 


Phe Thr Ala Ser Ala Arg Val Ile Lys Glu Arg Phe Gly Leu Ser Thr 
145                 150                 155                 160 


Glu Leu Glu Phe Leu Thr Lys Gly Arg Tyr Arg Thr Gln Thr Ile Asp 
                165                 170                 175     


Gly Lys Arg Ser Thr Lys Leu Asn Pro Asn Phe Ile Tyr Ser Leu Gln 
            180                 185                 190         


Asp Lys Asn Glu Arg Leu Asn Lys Met Gly Leu Ile Phe Leu Ala Cys 
        195                 200                 205             


Gln Leu Ile Glu Lys Lys Tyr Ala Ser Met Leu Phe Asp Gln Gln Gly 
    210                 215                 220                 


Tyr Met Gly Arg Asp Ile Tyr Phe Asp Phe Thr Pro Ala Gln Cys Lys 
225                 230                 235                 240 


Tyr Ile Arg Glu Val Phe Ser Ala His Arg Ile Val Leu Pro Arg Gly 
                245                 250                 255     


Arg Met Asp Val Glu Arg Asn Glu Ile Thr Ile Ala Met Asp Met Phe 
            260                 265                 270         


Asn Glu Leu Gly Lys Cys Pro Lys Glu Leu Phe Glu Ile Ile Ser Lys 
        275                 280                 285             


Glu Glu Gln Lys Arg Phe Arg Thr Lys Ser Glu Thr Thr Gly Glu Glu 
    290                 295                 300                 


Val Leu Leu Met Arg His Ser Asp Arg Phe Ala Thr Leu Ala Leu Gln 
305                 310                 315                 320 


Tyr Ile Asp Asn Arg Lys Val Phe Glu Lys Ile Arg Phe Gln Leu Ser 
                325                 330                 335     


Leu Gly Lys Tyr Arg Tyr Lys Phe Tyr Asp Lys Thr Cys Val Asp Gly 
            340                 345                 350         


Asp Thr His Val Arg Ile Leu Gln Lys Glu Leu Asn Gly Phe Gly Arg 
        355                 360                 365             


Ile Asn Glu Ile Glu Leu Leu Lys Glu Glu Lys Trp Gly Gly Leu Ile 
    370                 375                 380                 


Arg Lys Phe Glu Asp Ala Lys Ile Asp Thr Ala Glu Thr Lys Pro Tyr 
385                 390                 395                 400 


Ile Thr Asp Gln Tyr Pro Gln Tyr Leu Phe Asn Gly Asn Arg Ile Gly 
                405                 410                 415     


Ile Tyr Phe Asn Ser Ala His Gly Lys Ala Met Arg Asn Gly Ala Tyr 
            420                 425                 430         


Ile Pro Asp Ile Glu Ser Gly Ala His Cys Ile Gln Pro Ile Cys Trp 
        435                 440                 445             


Ile Ser Asn Tyr Glu Leu Pro Ala Leu Ile Phe His His Ile Leu Thr 
    450                 455                 460                 


Lys Asp Glu Lys Lys Ser Leu Thr Glu Lys Ile Ile Ile Asp Cys Val 
465                 470                 475                 480 


Glu Arg Tyr Lys Lys Leu Phe Asn Asp Ile Ala Glu Gly Lys Val Ala 
                485                 490                 495     


Arg Thr Gly Asn Ala Thr Ser Asp Phe Glu Met Ile Ser Lys Glu Tyr 
            500                 505                 510         


Gly Ile Glu Lys Ser Asp Ile Pro Arg Glu Leu Gln Asp Tyr Phe Asn 
        515                 520                 525             


Gly Thr Glu Arg Asp Gly Ile Glu Gln Tyr Ala Lys Ala Gln Ile Arg 
    530                 535                 540                 


Glu Met Ile Glu Glu Asn Arg Ile Arg Leu Glu Gln Phe Asn Ser Lys 
545                 550                 555                 560 


Leu Lys Lys Ile Glu Asp Gly Glu Val Lys Tyr Gly Lys Arg Asp Tyr 
                565                 570                 575     


Thr Glu Ile Arg Thr Gly Glu Leu Ala Gln Tyr Leu Ala Lys Asp Ile 
            580                 585                 590         


Val Met Phe Met Pro Lys Ala Lys Tyr Lys Pro Thr Ser Lys Asn Tyr 
        595                 600                 605             


Asn Val Met Gln Ala Leu Leu Ala Thr Phe Asn Gly Ser Glu Ser Gly 
    610                 615                 620                 


Ser Thr Leu Asp Glu Val Asp Asp Met Phe Asp Asn Ile Lys Ala Cys 
625                 630                 635                 640 


Tyr Trp Lys Asn Glu Ser Asp Asn His Pro Phe Leu Glu Tyr Val Leu 
                645                 650                 655     


Gly Glu Glu Pro Lys Asp Ile Ile Ala Phe Tyr Lys Ile Tyr Leu Glu 
            660                 665                 670         


Leu Arg Gly Glu Tyr Leu Asp Lys Cys Ile Lys Lys Met Asp Leu Ala 
        675                 680                 685             


Thr Ile Pro Phe Ile His Thr Glu Arg Lys Arg Trp Glu Lys Arg Asp 
    690                 695                 700                 


Glu Lys Phe Phe Lys Glu Leu Ala Gln Arg Tyr Ala Thr Gln Pro Ile 
705                 710                 715                 720 


Glu Leu Pro Arg Gly Leu Tyr Asp Arg Ala Ile Lys Glu Tyr Leu Lys 
                725                 730                 735     


Ser Lys Ser Ile Leu Glu Asp Val Ile Ala Gln Glu Gln Cys Asn Val 
            740                 745                 750         


Thr Tyr Leu Ile Ala Arg Tyr Met Gln Asp Val Leu Lys Asp Asp Ser 
        755                 760                 765             


Gln Gln Phe Tyr Ser Leu Pro Arg His Tyr Ser Cys Leu Ser Glu Lys 
    770                 775                 780                 


Asp Lys Tyr Leu Ser Leu Thr Glu Arg Glu Ala Ile Ala Lys Ser Asp 
785                 790                 795                 800 


Ala Leu Asn Ser Phe Lys Lys Arg Glu Arg Glu Lys Glu Asn Glu Asn 
                805                 810                 815     


Arg Arg Gly Asn Arg Arg Tyr Asn Lys Gly Glu Asn Lys Asn Thr Ile 
            820                 825                 830         


Lys Asp Arg Asp Thr Glu Glu Lys Phe Asn Ser Leu Tyr Arg Lys Met 
        835                 840                 845             


Asp Asn Asn Glu Arg Ile Leu Arg Arg Tyr Lys Val Gln Asp Met Leu 
    850                 855                 860                 


Leu Tyr Leu Leu Ala Cys Asp Ile Ile Lys Gly Ile Met Arg Glu Asp 
865                 870                 875                 880 


Phe Gly Tyr Lys Leu Ser Met Ile Thr Asp Gly Lys Asn Ser Asn Phe 
                885                 890                 895     


Phe Asp Tyr Lys Met Pro Glu Phe Lys Thr Thr Ile Thr Leu Lys Glu 
            900                 905                 910         


Gly Lys Lys Phe Thr Ile Lys Gln Gln Tyr Leu Lys Ile Lys Asn Tyr 
        915                 920                 925             


Gly Asp Phe Leu Lys Phe Ile Phe Asp Leu Arg Ile Asp Ser Leu Leu 
    930                 935                 940                 


Ser Asn Gly Thr Lys Val Glu Ile Asp Arg Asn Ile Leu Glu Asp Glu 
945                 950                 955                 960 


Leu Ser Asn Tyr Asp Gly Ser Arg Pro Lys Val Phe Glu Thr Leu Leu 
                965                 970                 975     


Met Ile Glu Lys Ile Val Val Glu Lys His Lys Glu Leu Lys Asp Leu 
            980                 985                 990         


Glu His Ile Thr Phe Gly Asp Val  Leu Asn Val Ile Lys  Met Glu Glu 
        995                 1000                 1005             


Gly Glu  Lys Lys Ile Leu Arg  Leu Ile Arg Asn Ala  Phe Ser His 
    1010                 1015                 1020             


Asn Tyr  Tyr Pro Thr Ile Lys  Asp Val Asn Tyr Asp  Asn Met Pro 
    1025                 1030                 1035             


Glu Val  Ala Glu Ser Leu Lys  Asp Ile Leu Glu Lys  Glu Ser Lys 
    1040                 1045                 1050             


Lys Leu  Thr Asn 
    1055         


<210>  1544
<211>  1148
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1544

Met Asp Asn Ser Thr Ser Lys Ser Phe Lys Arg Phe Phe Glu Phe Lys 
1               5                   10                  15      


Gly Asn Val Ala Pro Ile Ala Glu Lys Ala Asn Arg Asn Phe Asn Ile 
            20                  25                  30          


Lys Asn Leu Asn Pro Ile Asn Thr Gln Gln Arg Leu His Tyr Phe Ala 
        35                  40                  45              


Ile Gly His Val Phe Lys Ser Ile Asp Thr Glu Lys Ile Phe Thr Val 
    50                  55                  60                  


Leu Leu Asp Glu Val Ala Lys Val Lys Lys Pro Thr Lys Phe Ser Ala 
65                  70                  75                  80  


Leu Gln Asn Thr Glu Phe Thr Phe Ile Asn Glu Leu Lys Cys Leu Met 
                85                  90                  95      


Ser Asp Ile Arg Asn Ile Asn Ser His Phe Ile His Asp Phe Glu Lys 
            100                 105                 110         


Ile Lys Ile Asp Ser Ile Asp Lys Asn Ile Ile Glu Phe Leu Lys Gln 
        115                 120                 125             


Ser Phe Glu Leu Ala Val Leu Gln Thr Cys Met Asp Glu Lys Asn Ile 
    130                 135                 140                 


Asn Tyr Glu Glu Phe Thr Gly Gly Gly Asn Pro Glu Lys Glu Ile Val 
145                 150                 155                 160 


Asp Phe Leu Cys Asp Lys Phe Tyr Pro Lys Ile Asp Asn Ser Lys Asp 
                165                 170                 175     


Leu Ser Glu His Gln Lys Leu Ile Ser Asp Phe Lys Lys Lys Ser Lys 
            180                 185                 190         


Asp Glu Ala Ile Asn Glu Ile Leu Phe Ile Asn Val Ser Ser Asp Tyr 
        195                 200                 205             


Asn Trp Asn Ile Phe Glu Thr His Thr Val Phe Lys Ile Ser Lys Gly 
    210                 215                 220                 


Lys Tyr Leu Ser Phe Glu Ala Cys Leu Phe Leu Leu Ala Met Phe Leu 
225                 230                 235                 240 


Tyr Lys Gly Glu Ala Asn Gln Leu Ile Ser Lys Ile Lys Gly Phe Lys 
                245                 250                 255     


Arg Asn Asp Asp Asn Lys Phe Met Ser Lys Arg Asn Leu Phe Thr Phe 
            260                 265                 270         


Phe Ser Lys Lys Phe Ser Ser Gln Asp Ile Asp Ser Glu Glu Asn His 
        275                 280                 285             


Leu Val Lys Phe Arg Asp Leu Val Gln Tyr Leu Asn His Tyr Pro Thr 
    290                 295                 300                 


Val Trp Asn Lys Tyr Leu Glu Leu Gly Ser Asn Asn Pro Ile Met Thr 
305                 310                 315                 320 


Glu Arg Leu Lys Glu Lys Ile Ile Glu Leu Glu Ile Lys Arg Cys Phe 
                325                 330                 335     


Pro Glu Leu Ala Ser Asn Ser Ser Phe Asn Gln Phe Ala Ile Asn Tyr 
            340                 345                 350         


Ile Phe Lys Asn Gly Lys Ile Ile Glu Cys Glu Asn Asn Asn Ile Tyr 
        355                 360                 365             


Leu Asp Ile Ile Asn Lys Asn Asp Glu Val Arg Lys Ile Tyr Phe Ser 
    370                 375                 380                 


Ile Lys Asn Asn Glu Phe Asn Arg Ser Glu Phe Lys Asp Asn Ser Phe 
385                 390                 395                 400 


Lys Met Phe Ala Leu Lys Tyr Val Val Lys Glu Tyr Tyr Lys Glu Asn 
                405                 410                 415     


Lys Ala Tyr Ala Asp Tyr Leu Thr Lys Gln Ile Lys Asp Lys Glu Lys 
            420                 425                 430         


Thr Phe Asp Glu Glu Leu Ile Thr Asn Lys Lys Val Glu Lys Leu Lys 
        435                 440                 445             


Lys Gln Ile Ser Gln Asn Leu Asn Phe Ile Phe Tyr Gly Arg Asn Gln 
    450                 455                 460                 


Asp Arg Phe Met Glu Phe Ala Thr Arg Tyr Leu Ala Glu Thr Gly Tyr 
465                 470                 475                 480 


Phe Gly Lys Asp Ala Lys Phe Lys Met Tyr Glu Phe Phe Thr Thr Asp 
                485                 490                 495     


Glu Gln Ile Glu Glu Ile Asp Arg Leu Lys Arg Thr Ile Ser Lys Lys 
            500                 505                 510         


Glu Phe Asp Lys Leu Lys Phe His Gln Gly Lys Leu Val His Cys Ser 
        515                 520                 525             


Thr Tyr Ala Asp His Ile Ala Lys Tyr Lys Asn Trp Asp Thr Pro Phe 
    530                 535                 540                 


Val Val Glu Asn Asn Ala Val Gln Leu Thr Val Cys Phe Asp Asn Gly 
545                 550                 555                 560 


Gln Arg Lys Ile Leu Ser Ile Gln Arg Asn Leu Met Pro Tyr Phe Leu 
                565                 570                 575     


Glu Asp Ala Leu Tyr Asn Met Gln Asn Asp Lys Ile Glu Gly Ala Gly 
            580                 585                 590         


Lys Ile Leu Ile Glu Asn Tyr Tyr Asn Tyr His Lys Glu Gly Phe Glu 
        595                 600                 605             


Lys Ser Arg Leu Thr Leu Lys Gln Asn Asp Thr Ile Ser Leu Leu Glu 
    610                 615                 620                 


Lys Ala Thr Phe Lys Lys Ile Leu Pro Lys Arg Leu Leu His Arg Tyr 
625                 630                 635                 640 


Ser Pro Ala Val Gln Asn Asn Leu Pro Glu Asn Ser Thr Tyr Lys Gln 
                645                 650                 655     


Ile Leu Thr Lys Thr Lys Glu Ala Glu Glu Arg Tyr Val Lys Leu Leu 
            660                 665                 670         


Glu Lys Ala Lys Lys Asp Gly Tyr Glu Glu Asp Phe Leu Lys Arg Asn 
        675                 680                 685             


Lys Gly Lys Gln Phe Lys Leu Arg Phe Ile Arg Lys Ala Trp Asn Ile 
    690                 695                 700                 


Leu Phe Phe Lys Asp His Tyr Leu Lys Gln Val Gln Phe Ser Gly His 
705                 710                 715                 720 


His Arg Arg Phe Asn Ile Ser Arg Glu Glu Phe Asn Asp Phe Ser Lys 
                725                 730                 735     


Trp Met Phe Ala Phe Asp Glu Thr Pro Lys Tyr Lys Asp Tyr Leu Met 
            740                 745                 750         


Ile Leu Phe Glu Gln Lys Gly Phe Leu Glu Ile Ser Asn Phe Arg Thr 
        755                 760                 765             


Leu Phe Val Asn Ser Ser Ser Leu Asp Gly Leu Tyr Gly Lys Thr Lys 
    770                 775                 780                 


Ala Ile Tyr Glu Gly Trp Met Gln Asn Asn Asn Thr Asn Glu Lys Asn 
785                 790                 795                 800 


Pro Asp Lys Tyr Ser Leu Lys Asn Tyr Glu Lys Phe Phe Thr Asp Glu 
                805                 810                 815     


Leu Phe Tyr Ile Asn Val Ser His Phe Ile Ala Tyr Leu Asp Ile Ile 
            820                 825                 830         


Asn Lys Ile Arg Arg Asn Glu Lys Gly Gly Ile Ile Tyr Pro Cys Leu 
        835                 840                 845             


Glu Asn Glu Lys His Leu Ile Thr Glu Tyr Tyr Tyr Lys Val Lys Leu 
    850                 855                 860                 


Glu Glu Asn Glu Leu Lys Asn Cys Lys Lys Leu Phe Asn Lys Leu Met 
865                 870                 875                 880 


Ser Ala Lys Leu Glu Asp Ala Leu Leu Tyr Glu Ile Ser Met Tyr Tyr 
                885                 890                 895     


Leu Gly Ile Asp Asn Thr Ile Val Gln Lys Ala Arg Thr Asn Val Thr 
            900                 905                 910         


Asn Leu Leu Asn Gln Asp Val Val Phe Asn Ile Asn Asp Ala Asn Ser 
        915                 920                 925             


Asn His Leu Tyr Asp Leu Ser Ile Pro Phe Asn Lys Ile Asp Ser Tyr 
    930                 935                 940                 


Val Glu Leu Ile Lys His Lys Glu Asp Gln Glu Asn Asp Lys Lys Asn 
945                 950                 955                 960 


Lys Lys Thr Ser Phe Leu Gly Asn Met Pro Ser Tyr Ile Val Asn Val 
                965                 970                 975     


Ile Cys Lys Glu Thr Lys Asn Lys Glu Ser Cys Ser Ile Cys Asn Lys 
            980                 985                 990         


Tyr Ile Asn Phe Lys Lys Leu Asp  Phe Asp Asp Leu Asn  Lys Ile Asn 
        995                 1000                 1005             


Asn His  Ile Leu Ser Asn Ser  Val Lys Phe Thr Gln  Val Ala Leu 
    1010                 1015                 1020             


Ser Phe  Glu Glu Tyr Phe Ile  Phe Asn Glu Lys Lys  Ser Ile Ile 
    1025                 1030                 1035             


Lys Asn  Asn Arg Ile Asp Val  Asp Glu Phe Ser Phe  Trp Asn Ala 
    1040                 1045                 1050             


Tyr Phe  Ser Asp Ser Gly Leu  Thr Arg Lys Lys Ala  Phe His Phe 
    1055                 1060                 1065             


Gly Val  Pro Lys Glu Ser Tyr  Asp Asp Ile Ile Ala  Arg Met Glu 
    1070                 1075                 1080             


Asn Lys  Phe Val Lys Glu Gln  Ile Arg Pro Ser Leu  Pro Leu Asp 
    1085                 1090                 1095             


Tyr Asn  Ser Phe Asn Lys Gln  Gln Lys Ser Ile Cys  Asp Ala Leu 
    1100                 1105                 1110             


Leu Lys  Ser Ile His Ser Ser  Tyr Phe Asn His Arg  Glu Lys Asp 
    1115                 1120                 1125             


Lys Lys  Lys Lys Arg Asn Glu  Ala Asn Asn Met Tyr  Tyr Lys Glu 
    1130                 1135                 1140             


Val Ile  Leu Lys Lys 
    1145             


<210>  1545
<211>  1121
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1545

Met Asp Met Asp Glu Asn Ile Asn Tyr Tyr Asp Phe Asn Asn Ile Glu 
1               5                   10                  15      


Asp Lys His Phe Phe Ala Gly Tyr Tyr Asn Leu Ala Asn Asp Asn Phe 
            20                  25                  30          


Tyr Asn Val Leu Lys Glu Leu Lys Tyr Ile Ser Asp Lys Lys Leu Asp 
        35                  40                  45              


Ile Thr Glu Ile Asn Lys Ala Ser Tyr Ser Glu Leu Asp Thr Arg Leu 
    50                  55                  60                  


Asn Lys Leu Gln Arg Phe Leu Pro Phe Ile Pro Ser Leu Val Val Asp 
65                  70                  75                  80  


Lys Glu Ile Lys Asp Gln Lys Phe Glu Ile Thr Thr Leu Leu Lys Phe 
                85                  90                  95      


Leu Trp Ser Glu Ile Glu Lys Gln Arg Asn Phe Tyr Thr His Tyr Ala 
            100                 105                 110         


His Asn Arg Pro Glu Phe Ile Leu Glu Ser Asn Gln Gln Ile Leu Asn 
        115                 120                 125             


His Tyr Phe Ile Lys Ala Val Glu Leu Ile Lys Lys Ser Val Lys Asp 
    130                 135                 140                 


Glu Leu Cys Arg Asn Ser Ile Arg Glu His Phe Ser Val Glu Phe Asn 
145                 150                 155                 160 


Glu Leu Lys Val Leu Gln Lys Arg Tyr Ile Glu Glu Lys Ile Arg Asn 
                165                 170                 175     


Ser Lys Ser Asn Ser Glu Lys Lys Lys Tyr Ser Leu Asp Glu Glu Ser 
            180                 185                 190         


Ile Asn Asn Gly Ile Phe Asn Lys Leu Phe Lys Pro Tyr Ile Ile Lys 
        195                 200                 205             


Asp Lys Val Thr Gly Ile Leu Ser Ile Asn Asn Tyr Arg Leu Leu Phe 
    210                 215                 220                 


Asp Ser Ser Gly Tyr Leu Thr Lys His Gly His Leu Phe Leu Leu Ser 
225                 230                 235                 240 


Leu Phe Leu Lys Arg Asp Gln Met Glu Ser Leu Met Asp Lys Ile Glu 
                245                 250                 255     


Gly Tyr Lys Ala Ser His Lys Leu Tyr Phe His Leu Thr Arg Arg Ile 
            260                 265                 270         


Tyr Ser His Phe Cys Phe Lys Gly Ile Lys Arg Gln Ile Val Ser Gln 
        275                 280                 285             


His Ser Lys Thr Lys Leu Met Leu Gln Met Ala Asp Glu Leu Gly Lys 
    290                 295                 300                 


Ile Pro Glu Glu Leu Tyr Asn Leu Leu Asn Asn Asn Glu Lys Ala Glu 
305                 310                 315                 320 


Phe Ile Val Asp Ile Asn Glu Tyr Tyr Lys Asp Asn Asp Gln Asn Gly 
                325                 330                 335     


Glu Asn Pro Asp Glu Lys Arg Val Ile His Asp Val Val Arg Arg Arg 
            340                 345                 350         


Tyr Lys Gln Thr Asp Lys Ser Phe Ser Asp Thr Tyr Gly Thr Asn Lys 
        355                 360                 365             


Thr Ile Asp Lys Phe Glu Tyr Phe Ala Leu Arg Phe Phe Asp Glu Asp 
    370                 375                 380                 


Ser Lys Leu Lys Asn Ile Lys Phe Met Ile Asp Trp Gly Asn Val Ile 
385                 390                 395                 400 


Ile Asp Lys Arg Ser Lys Asn Ile Leu Asp Met Gln Thr Glu Arg Ile 
                405                 410                 415     


Ile Lys Lys Arg Val Thr Val Phe Glu Asn Ile Asn Thr Val Ile Asp 
            420                 425                 430         


Lys Lys Ile Glu Leu Val Asn Ser Asn Asn Cys Asn Gly Gln Ile Leu 
        435                 440                 445             


Ile Asp Glu Glu Asn Ser Thr Cys Leu Ile Glu Gly Tyr Pro Phe Pro 
    450                 455                 460                 


Ala Asn Pro Ser Tyr Tyr Phe Gln Gly His Asn Ile Pro Ile Tyr Leu 
465                 470                 475                 480 


Ser Tyr Asn Asn Lys Lys Glu Ala Asp Cys Glu Asp Thr Glu Ile Asn 
                485                 490                 495     


Lys Val Arg Asn Ala Val Leu Lys Asn Thr Leu Gly Asp Asn Val Phe 
            500                 505                 510         


Pro Asn Lys Pro Asn Ala Leu Leu Ser Leu Tyr Glu Leu Pro Ala Met 
        515                 520                 525             


Leu His Val Tyr Phe Asn His Ala Asn Lys Glu Lys Glu Val Phe Lys 
    530                 535                 540                 


Leu Leu Ile Asn Lys Tyr Phe Lys Tyr Lys Lys Asp Leu Asn Phe Lys 
545                 550                 555                 560 


Glu Asn Ile Asn Asp Asn Gln Leu Val His Leu Lys Lys Ile Lys Asn 
                565                 570                 575     


Asn Lys Ile Leu Leu Glu Lys Asn Glu Tyr Thr Phe Asn Arg Gln Lys 
            580                 585                 590         


Leu Val Ser Asp Ile Asn Lys Glu Ile Ile Lys Thr Glu Ile Lys Ile 
        595                 600                 605             


Asn Glu Phe Asn Lys Cys Lys Leu Glu Tyr His Asp Ile Lys Asn Lys 
    610                 615                 620                 


Arg Lys Tyr Leu Met Tyr Asn Ser Glu Lys Gly Leu Val Ala Thr Phe 
625                 630                 635                 640 


Leu Ala Asp Glu Ile Leu Arg Trp Met Pro Arg Asn Leu Lys Glu Asn 
                645                 650                 655     


Trp Lys Gly Tyr His His Ser Glu Leu Gln Lys Leu Leu Ser Phe Phe 
            660                 665                 670         


Gln Ile Glu Lys Asn Asn Ile Asn His Leu Ile Ile Phe Asp Asp Lys 
        675                 680                 685             


Phe Asp Phe Leu Arg Asp Ile Phe Lys Lys Ser Asn Ser Leu Glu Asp 
    690                 695                 700                 


Leu Tyr Ile Asn Tyr Leu Asn Gly Lys Ile Glu Lys Leu Lys Ser Phe 
705                 710                 715                 720 


Leu Ser Ile Leu Asp Ile Lys Glu Lys Lys Val Leu Lys Lys Gly Leu 
                725                 730                 735     


Cys Asp Ile Trp Val Phe Phe Lys Gln Ser Lys Tyr Asn Ile Lys Asn 
            740                 745                 750         


Ile Asn Ser Tyr Ser Glu Glu Leu Leu Lys Lys Pro Ile Leu Leu Gly 
        755                 760                 765             


Arg Gly Ile Phe Asp Asp Thr Pro Thr Phe Tyr Pro Ser Asp Leu Lys 
    770                 775                 780                 


Asp Asn Pro Lys Ala Asn Trp Phe Glu Thr Val Lys Lys Asn Gln Ser 
785                 790                 795                 800 


Tyr Gln Ser Phe Tyr Asn Leu Leu Glu Asp Lys Leu Lys Pro Val Ser 
                805                 810                 815     


Gly Glu Ser Ser Val Glu Lys Arg Arg Arg Ile Glu Lys Tyr Arg Ser 
            820                 825                 830         


Ile Glu Tyr Gln Lys Ile Lys Asp Ile Tyr Thr Leu Glu Met Phe Lys 
        835                 840                 845             


His Leu Tyr Lys Glu Ile Phe Gly Asn Glu Glu Ile Met Glu Asn Ile 
    850                 855                 860                 


Thr Leu Thr Asp Phe Tyr Gln Ser Pro Ala Glu Arg Lys Lys Met Ile 
865                 870                 875                 880 


Ala Asn Ala Ser Ser Gln Asn Asn Arg Asn Gln Gly Asn Cys Ser Lys 
                885                 890                 895     


Asn Lys Tyr Asn Glu Leu Gly Ile Trp Asn Lys Val Thr Pro Cys Asn 
            900                 905                 910         


Phe Glu Asn Gly Arg Val Val Ala Pro Gln Ile Lys Leu Lys Glu Ile 
        915                 920                 925             


Gly Lys Phe Glu Gln Leu Leu Leu Asp Asp Lys Val Lys Ala Ile Leu 
    930                 935                 940                 


Ser Tyr Asn Asp Gln Ile Trp Gln Lys Gln Glu Leu Glu Arg Glu Leu 
945                 950                 955                 960 


Glu Ser Tyr Arg Ile Val Arg Glu Glu Lys Leu Phe Lys Ile Ile His 
                965                 970                 975     


Asn Leu Glu Lys Val Ile Leu Glu Ile Glu Thr Leu His Arg Glu Asp 
            980                 985                 990         


Lys Ser His Pro Ile Ile Phe Asn  Asn Gly Glu Tyr Pro  Asn Phe Arg 
        995                 1000                 1005             


Lys Tyr  Ile Glu Asn Ser Lys  Ile Phe Asn Trp Ser  Gln Glu Asp 
    1010                 1015                 1020             


Lys Asn  Ile Ile Asn Cys Phe  Asn Ser Glu Leu Leu  Glu Asn Ser 
    1025                 1030                 1035             


Phe Pro  Glu Ile Ile Val Asn  Ala Asn Pro Arg Leu  Gln Lys Ala 
    1040                 1045                 1050             


Ile Leu  Leu Ile Tyr Ile Arg  Asn Lys Phe Ala His  Asn Gln Leu 
    1055                 1060                 1065             


Pro Ser  Lys His Val His Asn  Phe Cys Lys Lys Ile  Ser Cys Ile 
    1070                 1075                 1080             


Asn Asp  Glu Arg Val Thr Thr  Tyr Ala Glu Phe Tyr  Leu Met Ile 
    1085                 1090                 1095             


Val Glu  Asn Phe Ile Leu Asp  Gln Asn Phe Ile Lys  Thr Lys Gln 
    1100                 1105                 1110             


Val Tyr  Asn Asn Asn Ser Ile  Ser 
    1115                 1120     


<210>  1546
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1546

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Ala Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Asn Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1547
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1547

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1548
<211>  1103
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1548

Met Glu Asn Lys Glu Gln Asn Lys Arg Thr Trp Asp Asn Asp Pro Gln 
1               5                   10                  15      


Tyr Phe Gly Ser Tyr Leu Asn Met Ala Arg Leu Asn Ile Phe Asn Ile 
            20                  25                  30          


Ser Asn His Leu Ala Lys Lys Phe Gly Leu Thr Val Leu Glu Asp Glu 
        35                  40                  45              


Gly Lys Ile Thr Ile Ser Phe Leu Gly Asp Lys Glu Asn Lys Lys Tyr 
    50                  55                  60                  


Lys Thr Lys Gln Gly Leu Ile Tyr Ser Asn Leu Thr Arg Tyr Met Pro 
65                  70                  75                  80  


Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Glu Asn Glu Arg Asn 
                85                  90                  95      


Lys Val Lys Asn Asn Phe Gly Lys Asp Phe Asn Arg Leu Ser Asp Thr 
            100                 105                 110         


Leu Lys Ile Val Phe Lys Glu Leu Asn Glu Phe Arg Asn Asp Tyr Ser 
        115                 120                 125             


His Tyr Tyr Ser Thr Glu Lys Gln Asp Lys Arg Lys Leu Glu Ile Ser 
    130                 135                 140                 


Ser Glu Leu Asn Asp Phe Leu Thr Leu Asn Phe Ser Arg Ala Val Ser 
145                 150                 155                 160 


Tyr Thr Lys Glu Arg Phe Lys Asp Val Phe Ser Asp Glu Asp Phe Lys 
                165                 170                 175     


Ile Ala Ser Gln Thr Ile Val Val Asn Asn Asp Lys Thr Ile Thr Gln 
            180                 185                 190         


Asp Gly Ile Val Phe Leu Thr Ser Met Phe Leu Asp Arg Glu Asn Ala 
        195                 200                 205             


Phe Arg Phe Ile Asn Lys Ile Ile Gly Leu Lys Gly Thr Gln Thr Asn 
    210                 215                 220                 


Glu Phe Lys Ala Lys Arg Glu Val Leu Leu Phe Phe Cys Val Lys Leu 
225                 230                 235                 240 


Pro His Asp Lys Phe Val Ser Glu Asn Thr Glu Leu Ala Phe Ser Leu 
                245                 250                 255     


Asp Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu Tyr Asn Val 
            260                 265                 270         


Ile Thr Glu Glu Glu Lys Gln Leu Phe Arg Pro Thr Leu Glu Thr Glu 
        275                 280                 285             


Gln Ile Lys Asn Val Leu Gln Asn Ser Val Pro Asp Thr Ile Asp Asp 
    290                 295                 300                 


Tyr Glu Asn Tyr Ile Glu Gly Ile Thr Lys Lys Val Arg Asn Glu Asn 
305                 310                 315                 320 


Arg Phe Ser Tyr Phe Ala Leu Lys Tyr Ile Asp Gln Lys Glu Leu Phe 
                325                 330                 335     


Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val Leu Asp Glu 
            340                 345                 350         


Tyr Tyr Lys Gln Leu Asn Gly Lys Asp Glu Val Arg Thr Val Thr Glu 
        355                 360                 365             


Asn Ala Lys Ala Phe Gly Arg Leu Gln Asp Leu Asn Asp Glu Glu Asn 
    370                 375                 380                 


Thr Leu Lys Lys Ile Asn Thr Gly Glu Asn Lys Thr Cys Phe Asp Gln 
385                 390                 395                 400 


Phe Ala Pro His Tyr Asn Phe Asp Asp Lys Asn Asn Lys Ile Gly Ile 
                405                 410                 415     


Ser Lys Lys Glu Ile Thr Ser Arg Phe Ile Ser Gln Lys Thr Asp Lys 
            420                 425                 430         


Lys Val Lys Phe Asn Leu Leu Gln Pro Leu Pro Glu Ala Phe Leu Ser 
        435                 440                 445             


Ile His Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu Glu Gln Gly 
    450                 455                 460                 


Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn Asn Ala Lys 
465                 470                 475                 480 


Ile Ile Asn Arg Glu Phe Ile Glu Thr Ile Lys Ser Lys Leu Ser Glu 
                485                 490                 495     


Phe Asn Val Phe His Lys Arg Ser Gln Gly Arg Lys Glu Lys Arg Ala 
            500                 505                 510         


Tyr Ser Glu Gly Ala Leu Lys Tyr Leu Leu Glu Arg Lys Glu Lys Leu 
        515                 520                 525             


Asn Gln Ile Leu Ala Glu His Asn Leu Asn Val Lys Gln Ile Pro Ala 
    530                 535                 540                 


Arg Ile Leu Asp Tyr Trp Leu Asn Ile Glu Asp Val Gln Glu Lys Thr 
545                 550                 555                 560 


Ala Ile Ser Gly Arg Ile Lys Leu Met Lys Arg Asp Cys Met Asp Arg 
                565                 570                 575     


Leu Lys Ala Ile Lys Lys Lys Asn Pro Pro Lys Ile Gly Glu Met Ala 
            580                 585                 590         


Thr Phe Leu Ala Lys Asp Val Val Asp Met Ile Ile Ser Glu Glu Lys 
        595                 600                 605             


Lys Lys Lys Ile Thr Ser Phe Tyr Tyr Asp Lys Ile Gln Glu Cys Leu 
    610                 615                 620                 


Ala Leu Phe Ala Asp Lys Glu Lys Lys Glu Leu Phe Ile Gln Ile Cys 
625                 630                 635                 640 


Asn Glu Leu Lys Leu Asn Asn Glu Ser Asp Gly His Pro Phe Leu Lys 
                645                 650                 655     


Asn Ile Asn Leu Asn Glu Phe Arg Tyr Thr Ser Asp Leu Tyr Lys Lys 
            660                 665                 670         


Tyr Ala Glu Glu Lys Arg Leu Tyr Leu Glu Asn Asn Phe Tyr Lys Lys 
        675                 680                 685             


Glu Arg Asn Glu Lys Ala Lys Lys Asp Leu Thr Val Val Val Leu Pro 
    690                 695                 700                 


His Asp Lys Ser Lys Ile Pro Phe Ser Ile Arg Gln Leu Glu Lys Glu 
705                 710                 715                 720 


Lys Thr Ser Phe Asp Lys Trp Leu Glu Tyr Val Thr Lys Gly Lys Glu 
                725                 730                 735     


Thr Thr Asp Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp 
            740                 745                 750         


Asp Thr Leu Lys Arg Leu Leu Lys Thr Glu Leu Ser Lys Asn Asn Ile 
        755                 760                 765             


Glu Phe Asp Asn Asp Ala Asn Asn Asn Glu Leu Phe Lys Thr Trp Trp 
    770                 775                 780                 


Ser Gln Cys Arg Glu Asp Asp Val Gln Lys Phe Tyr Thr Ala Glu Arg 
785                 790                 795                 800 


Glu Tyr Thr Phe Glu Lys Gly Lys Leu Thr Phe Lys Ile Asn Ser Lys 
                805                 810                 815     


Ser Lys Phe Glu Glu Tyr Ile Asn Gln Glu Phe Ile Glu Asn Val Phe 
            820                 825                 830         


Lys Ser Lys Ser Arg Lys Arg Glu Asn Glu Asn Asn Thr Gly Arg Lys 
        835                 840                 845             


Leu Pro Pro Leu Arg Ile Lys Glu Val Thr Lys Asn Ile Val Lys Lys 
    850                 855                 860                 


Ile Gly Asn Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg 
865                 870                 875                 880 


Leu Met Leu Leu Met Phe Glu Gln Leu Thr Lys Lys Glu Leu Asn Val 
                885                 890                 895     


Lys Leu Lys Asn Thr Asp Asp Leu Leu Asn Glu Gln Ile Glu Ile Gly 
            900                 905                 910         


Glu Asn Ile Ser Gly Lys Leu Val Phe Asp Glu Phe Gly Gln Leu Ile 
        915                 920                 925             


Glu Glu Lys Lys Asn Gln Lys Thr Ile Ala Lys Asn Ile Val Glu Thr 
    930                 935                 940                 


Arg Lys Arg Lys Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Lys 
945                 950                 955                 960 


Arg Leu Pro Glu Leu Phe Glu Tyr Phe Glu Glu Glu Asn Ile Pro Met 
                965                 970                 975     


Glu Lys Ile Lys Leu Glu Leu Asp Ser Tyr Thr Lys Ala Lys Asp Ile 
            980                 985                 990         


Ile Phe Asp Leu Ala Phe Lys Leu  Glu Glu Thr Ile Ile  Lys Lys Asp 
        995                 1000                 1005             


Glu Ser  Gly Ile Lys Glu Leu  Asn Lys Asp Pro Glu  Gly Asn Ile 
    1010                 1015                 1020             


Gln Ser  Gly Asn Ile Gln His  Lys Pro Tyr Leu His  Trp Leu Leu 
    1025                 1030                 1035             


Lys Asn  Asp Leu Ile Ser Glu  Lys Glu Phe Thr Phe  Met Asn Met 
    1040                 1045                 1050             


Val Arg  Asn Thr Phe Ser His  Asn Gln Phe Pro Gln  Lys Lys Thr 
    1055                 1060                 1065             


Met Glu  Leu Phe Ile Arg His  Trp Asp Lys Gln Asn  Leu Ala Met 
    1070                 1075                 1080             


Gln Ile  Ala Glu Val Tyr Asn  Gln Lys Ile Val Glu  Ile Ala Ala 
    1085                 1090                 1095             


Lys Cys  Lys Glu Met 
    1100             


<210>  1549
<211>  1065
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1549

Met Arg Asp Pro Ser Ser Glu Glu Met Lys Val Ser Thr Glu Ala Val 
1               5                   10                  15      


Leu Ala Ala Tyr Leu Asn Thr Ala Lys Asn Asn Leu Phe Ile Ile Ile 
            20                  25                  30          


Asn Asp Val Ser Lys Ser Leu Gly Leu Gly Phe His Asp Lys Asn Asp 
        35                  40                  45              


Asn Ile Leu Asn Ala Ala Leu Phe Lys His Leu Ser Asn Ser Asn Ser 
    50                  55                  60                  


Pro Asp Val Gln Leu Gln Ile Ile Asn Lys Leu Asn Arg Cys Ile Pro 
65                  70                  75                  80  


Ala Leu Lys Asp Leu Ala Ile Lys His Ala Asn Asp Ala Arg Asn Asn 
                85                  90                  95      


Asn Glu Glu Asn Asn Asn Val Gln Glu Val Thr Thr Pro Gly Ser Thr 
            100                 105                 110         


Asp Tyr Ser Glu Ile Phe Lys Lys Tyr Ile Arg Leu Val Leu Asp Tyr 
        115                 120                 125             


Arg Asn Phe Tyr Ser His Ala Glu His Asp Ile Val Thr Val Glu Lys 
    130                 135                 140                 


Ser Ile Ile Lys Gly Leu Glu Met Leu Phe Asp Lys Ser Arg Arg Thr 
145                 150                 155                 160 


Val Lys Glu Arg Phe Asn Leu Pro Glu Asn Glu Val Gln His Leu Val 
                165                 170                 175     


Arg Leu Gly Lys Asp Lys Lys Glu Ala Pro Gly Phe Lys Tyr Ser Phe 
            180                 185                 190         


Trp Ala Asp Gln Gly Thr Gly Ile Ser Gln Lys Gly Phe Leu Phe Phe 
        195                 200                 205             


Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Gln Glu Met Leu Lys Lys 
    210                 215                 220                 


His Thr Gly Phe Lys Arg Ser Asp Gln Val His Gln Lys Ala Thr Leu 
225                 230                 235                 240 


Glu Thr Phe Thr Ile Tyr Cys Leu Lys Pro Pro Lys Asn Arg Leu Arg 
                245                 250                 255     


Ser Glu Ser Gln Glu Asp Ala Ile Val Leu Asp Met Phe Asn Glu Leu 
            260                 265                 270         


Ser Lys Cys Pro Asn Glu Leu Phe Glu Thr Leu Ser Lys Glu Asp Lys 
        275                 280                 285             


Ser Lys Phe Ile Lys Leu Asp Asp Gln Pro Ser Asp Asp Asn Glu Tyr 
    290                 295                 300                 


Ser Ser Leu Pro Ile Leu Arg Arg Ser Gly Asn Arg Phe Tyr Tyr Phe 
305                 310                 315                 320 


Gly Leu Lys Tyr Leu Glu Glu Lys Leu Asn Gly Ile Lys Phe Gln Ile 
                325                 330                 335     


Asp Leu Gly Asp Tyr Cys Tyr His Thr Tyr Asn Gln Thr Ile Asn Gly 
            340                 345                 350         


Ile Asp His Lys Arg Lys Tyr Ile Lys Lys Val Thr Ser Phe Gly Lys 
        355                 360                 365             


Leu Ala Glu Phe Ser Pro Asp Asn Arg Pro Glu Lys Trp Gly Glu Met 
    370                 375                 380                 


Ile Gln Thr Ile Asp Thr Leu Asn Thr Ser Pro Lys Asp Val Tyr Ile 
385                 390                 395                 400 


Thr Asp Thr Phe Pro His Phe His Ile Asn Gly Gln Asn Ile Gly Ile 
                405                 410                 415     


Thr Phe Thr Asp Ala Ile Lys Pro Val Asn Lys Trp Gly Asp Leu Pro 
            420                 425                 430         


Thr Tyr Asp Ser Asp Arg Lys Gln Pro Lys Arg Asn Asn Ile Ile Pro 
        435                 440                 445             


His Cys Trp Leu Ser Leu Tyr Glu Leu Pro Ala Ile Ile Phe Tyr Asp 
    450                 455                 460                 


Leu Ile Lys Asn Asn Ala Ala Pro Glu Lys Gly Tyr Lys Ser Val Glu 
465                 470                 475                 480 


Glu Ile Ile Lys Asn Tyr Tyr Asn Asn Leu Arg Lys Phe Phe Ser Tyr 
                485                 490                 495     


Ile Val Lys Ser Asn Ile Asn Thr Glu Glu Asp Phe Glu Arg Thr Leu 
            500                 505                 510         


Ala Glu Tyr Asn Leu Asn Lys Lys Asp Ile Pro Lys Ala Ile Ile Asn 
        515                 520                 525             


His Tyr Arg Thr His Ser Gln Asn Arg Asn Asn Gly Leu Ser Ser Tyr 
    530                 535                 540                 


Asp Ser Ile Leu Glu Glu Thr Lys Lys Arg Leu Lys Lys Ala Glu Asn 
545                 550                 555                 560 


Leu Arg Lys Gly Thr Tyr Lys Ile Asn Glu Lys Gly Asn Lys Ile Ile 
                565                 570                 575     


Leu Arg Pro Asn Asn Lys Asn Tyr Asn Glu Val Lys Pro Gly Lys Ile 
            580                 585                 590         


Ala Asp Phe Leu Ala Arg Asp Met Ile Leu Phe Gln Lys Pro Asp Pro 
        595                 600                 605             


Asp Ser Lys Asn Asn Gly Lys Ala Asn Pro Val Glu Phe Lys Leu Leu 
    610                 615                 620                 


Gln Ala Gly Leu Ala Phe Phe Asp Asp Arg Lys Glu Thr Ser Arg Leu 
625                 630                 635                 640 


Tyr Ala Ile Leu Lys Lys Cys Asn Leu Ile Gly Ser His Asn Pro His 
                645                 650                 655     


Pro Phe Ile Asp Asp Lys Ile Ile Asn Asn Ser Lys Ser Leu Leu Glu 
            660                 665                 670         


Phe Tyr Ile Glu Tyr Leu Lys Arg Lys Glu Asp Tyr Leu Glu Lys His 
        675                 680                 685             


Lys Thr Asp Ile His Phe Leu His Lys Asp Lys Met Ala Leu Asn Asn 
    690                 695                 700                 


Leu Val Asp Lys Leu Ile Asn Lys Tyr Arg Asp Lys Asp Tyr Thr Ile 
705                 710                 715                 720 


Phe Asn Leu Pro Arg Gly Leu Phe Leu Glu Pro Ile Lys Glu Ile Leu 
                725                 730                 735     


Lys Asn Glu Tyr Asn Lys Asn Phe Asp Ser Ile Ser Ser Ala Ser Tyr 
            740                 745                 750         


Ile Ile Glu Lys Tyr Phe Thr Asp Glu Val Lys Asp Thr Pro Gln Glu 
        755                 760                 765             


Phe Tyr Asn Tyr Lys Arg Ile Tyr Arg Ile Leu Asn Lys Leu Asn Asn 
    770                 775                 780                 


Glu Asn Asp Lys Gly His Ser Ile Gln Glu Met Ala Ala Asp Lys Asp 
785                 790                 795                 800 


Lys Phe Ile Lys Asn Ile Pro Val Leu Cys Arg Lys Asn Ala Arg Asn 
                805                 810                 815     


Asn Lys Cys Asp Phe Thr Pro Asn Glu Cys Ala Glu Lys Leu Asn Ser 
            820                 825                 830         


Thr Asn Cys Lys Tyr Leu Lys Glu Phe Lys Glu Tyr Leu Glu Asn Glu 
        835                 840                 845             


Lys Gln Ile Arg Leu His Lys Thr Cys Asp Met Val Leu Phe Leu Ile 
    850                 855                 860                 


Leu Gln Glu Tyr Leu Ser Thr Leu His Gly Tyr Ala Ile Glu Ala Lys 
865                 870                 875                 880 


Glu Phe Arg Leu Glu Asp Ile Leu Pro Thr Asn Asp Lys Tyr Leu Ser 
                885                 890                 895     


Lys Thr Val Asn Asn Val Lys Leu Thr Ile Gly Thr Lys Thr Ile Val 
            900                 905                 910         


Lys Asp Ser Ile Lys Ile Lys Asn Tyr Gly Asp Phe Arg Thr Ile Ile 
        915                 920                 925             


Asn Asp Arg Arg Leu Glu Lys Leu Phe Lys Tyr Lys Ala Ser Asp Glu 
    930                 935                 940                 


Ile Glu Tyr Asp Glu Ile Lys Glu Glu Phe Glu Lys Tyr Asp Lys Ala 
945                 950                 955                 960 


Arg Arg Thr Val Phe Glu Lys Ile Ile Asn Phe Glu Lys Phe Val Ile 
                965                 970                 975     


Ala Lys Leu Glu Ile Gly Lys Asp Gly Gly Lys Tyr Ile Asn His Lys 
            980                 985                 990         


Lys Ile Leu Glu Asn Leu Gln Asn  Gln Asn Leu Asn Gly  Ile Asn Ala 
        995                 1000                 1005             


Gly Ile  Tyr Glu Glu Ile Gly  Thr Ile Arg Asn Ala  Phe Cys His 
    1010                 1015                 1020             


Ser Glu  Tyr Pro Asp Pro Asp  Lys Leu Lys Leu Ser  Ile Asp Lys 
    1025                 1030                 1035             


Tyr Asn  Pro Gly Glu Ser Ser  Val Ala Glu Gly Leu  Leu Lys Met 
    1040                 1045                 1050             


Ile Gly  Asp Asp Tyr Asp Ala  Ile Met Ser Val Leu  
    1055                 1060                 1065 


<210>  1550
<211>  1085
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1550

Met Lys Lys Glu Leu Asn Arg Glu Asp Val Phe Thr Gly Gly Lys Thr 
1               5                   10                  15      


Pro Glu Leu Thr Ile Tyr Tyr Asn Ile Ala Tyr Phe Arg Met Ala Gly 
            20                  25                  30          


Leu Ile Asn Ala Leu Cys Gly Asn Lys Leu Glu Arg Asp Lys Asp Ala 
        35                  40                  45              


Leu Glu Gln Phe Met Lys Ala Phe Ile Asn Gly Lys Gln Lys Leu Thr 
    50                  55                  60                  


Asp Met Gln Phe Val Lys Leu Cys Asp Tyr Leu Trp Lys Gly Tyr Lys 
65                  70                  75                  80  


Tyr Asp Lys Asn Arg Ser Glu Tyr Ser Leu Thr Glu Asn Asp Lys Thr 
                85                  90                  95      


Met Val Leu Lys Met Val Ala Lys Leu Gln Asp Ile Arg Asn Phe Gln 
            100                 105                 110         


Ser His Ile Trp His Asp Asn Lys Val Leu Val Phe Asp Ala Asp Leu 
        115                 120                 125             


Val Gln Phe Ile Lys Asn Lys His Leu Glu Ala Ile Asp Ala Gln Arg 
    130                 135                 140                 


Gln Arg Phe Ser Lys Glu Thr Glu Val Tyr Glu Lys Glu Asn Arg Glu 
145                 150                 155                 160 


Leu Lys Lys Lys Lys Asn Lys Glu Leu Leu Phe Asp Ile His Asp Gly 
                165                 170                 175     


Leu Gly Tyr Ile Thr Gly Glu Gly Arg Asn Phe Phe Leu Ser Phe Phe 
            180                 185                 190         


Leu Thr Arg Gly Glu Met Thr Arg Phe Leu Lys Gln Arg Lys Gly Cys 
        195                 200                 205             


Lys Arg Asp Asp Thr Pro Glu Tyr Lys Ile Lys His Leu Val Tyr Arg 
    210                 215                 220                 


His Phe Thr His Arg Asp Gly Ala Thr Arg Thr His Tyr Gly Tyr Glu 
225                 230                 235                 240 


Asp Asn Met Leu Asp Gln Leu Pro Asp Lys Gln Glu Phe Leu Thr Thr 
                245                 250                 255     


Arg His Thr Tyr Arg Leu Ile Asn Tyr Leu Asn Asp Ile Pro Glu Glu 
            260                 265                 270         


Val Thr Asn Pro Glu Leu Phe Pro Leu Phe Asn Thr Ile Ser Asn Gly 
        275                 280                 285             


Ile Leu Ile Lys Glu Ser Val Gly Thr Tyr Ile Ala Phe Ile Asn Lys 
    290                 295                 300                 


Met Pro Leu Leu Ser Asp Phe Glu Phe Ser Glu Val Trp Gly Lys Asp 
305                 310                 315                 320 


Gly Lys Pro Tyr Thr Asn Leu Val Glu Phe Tyr His Lys Thr Gln Pro 
                325                 330                 335     


Gly Phe Lys Phe Arg Thr Asp Leu Asn Ser Phe His Lys Ile Ile Leu 
            340                 345                 350         


Asn Leu Ile Arg Asp Glu Asn Tyr Thr Gly Phe Phe Thr Thr Gln Leu 
        355                 360                 365             


Asn Leu Phe Met Ala His Arg Glu Glu Leu Ile Leu Val Ile Ser Lys 
    370                 375                 380                 


Pro Leu Ile Thr Pro Asn Asp Leu Leu Leu Ile Glu Glu His Tyr Arg 
385                 390                 395                 400 


Tyr Lys Leu Lys Ala Asn Asp Phe Val Arg Glu Lys Leu Gly Glu Trp 
                405                 410                 415     


Lys Glu Lys Ile Glu Lys Gly Lys Trp Glu Lys Ala Asn Glu Gln Lys 
            420                 425                 430         


Asp Lys Leu Ile Asn Leu Leu Gly Gly Val Ile Glu Ile Thr Phe Tyr 
        435                 440                 445             


Asp Phe Tyr Trp Gln Lys Asp Glu Lys Pro Arg Asn Glu Asn Arg Phe 
    450                 455                 460                 


Met Glu Phe Ala Ile Arg Phe Met Ala Asp Phe Asn Leu Leu Pro Asp 
465                 470                 475                 480 


Cys Glu Trp Glu Val Glu Pro Leu Gln Ile Glu Asn Asp Leu Ile Ala 
                485                 490                 495     


Asn Arg Thr Ala Thr Pro Asp Leu Lys Lys Ser Gly Ser Gln Phe Met 
            500                 505                 510         


Asn Gln Leu Thr Asp Asn Tyr Arg Leu Lys Phe Asn Asp Gly Gln Ile 
        515                 520                 525             


Ala Phe Arg Tyr Gln Asn Gln Val Phe Ile Met Gly His Lys Ala Val 
    530                 535                 540                 


Lys Asn Leu Leu Ile Ala Cys Phe Asp Gly Lys Glu Lys Met Leu Asn 
545                 550                 555                 560 


Gly Phe Met Pro Ala Leu Leu Ala Asp Leu Lys Lys Ile Thr Asn Glu 
                565                 570                 575     


His Ile Leu Lys Asn His Gln Ala Leu Asn Thr Leu Ser Leu Leu Asn 
            580                 585                 590         


Asn Asp Ser Ile Pro Ser Tyr Ile Ser Arg Gln Trp Gly Glu Ala Glu 
        595                 600                 605             


Pro Ile Thr Asp Met Lys Lys Lys Ala Ile Ala Arg Met Asp Tyr Ile 
    610                 615                 620                 


Thr Gln Gln Phe Glu Ala Leu Ile Glu Asn His His Tyr Leu Asn Arg 
625                 630                 635                 640 


Ala Asp Lys Asn Arg Gln Ile Met Arg Cys Tyr Lys Phe Phe Glu Trp 
                645                 650                 655     


Gln Tyr Pro Gln Asn Ser Gln Phe Lys Phe Leu Arg Arg Asn Glu Tyr 
            660                 665                 670         


His Arg Met Ser Ile Tyr His Tyr Cys Leu Asp Lys Glu Gln His Lys 
        675                 680                 685             


Tyr Asp Lys Lys Gly His Asn Tyr Leu Tyr Asn Arg Leu Ile Lys Glu 
    690                 695                 700                 


Ser His Asn Glu Ser Gly Asn Ile Glu Gln His Leu Pro Tyr Gln Ile 
705                 710                 715                 720 


Arg Thr Met Leu Asn Asp Ala Lys Asp Phe Asn Asp Tyr Phe Leu Arg 
                725                 730                 735     


Ile Leu Asn Ala Thr His Lys Ile Leu Thr Asp Trp Lys Asn Gln Leu 
            740                 745                 750         


Lys Gln Gly Arg Glu Pro Asn Asn Tyr Tyr Leu Ser Arg Leu Gly Phe 
        755                 760                 765             


Thr Gly Gly Leu Thr Gln Lys Val Val His Thr Arg Leu Leu Pro Phe 
    770                 775                 780                 


Ser Ile His Pro Gly Ile Pro Val Ser Phe Phe Tyr Arg Thr Glu Met 
785                 790                 795                 800 


Asn Gln Asn Pro Ser Phe Asn Leu Ser Ala Lys Val Trp Asn Ser Glu 
                805                 810                 815     


Ser Pro Phe Arg Val Gly Leu Lys Glu Ser Asn Tyr Gln Tyr Ala Lys 
            820                 825                 830         


Tyr Leu Gly Leu Phe Asn Glu Ile Lys Thr Gln Arg Lys Ile Ile Gly 
        835                 840                 845             


Lys Met Asn Gln Leu Ile Ala Glu Asp Ala Leu Leu Trp Gln Ile Ala 
    850                 855                 860                 


Lys Lys Tyr Leu Asp Lys Cys His Pro Lys Phe Ser Glu Ile Ile Asn 
865                 870                 875                 880 


Gln Gln Val Asn Gly Lys Gln Pro Leu Asn Val Lys Ala Ile His Asp 
                885                 890                 895     


Thr Glu Leu Thr Ile Asp Phe Pro Val Asp Lys Asn Leu Tyr Gln Val 
            900                 905                 910         


Val Val Lys Met Lys Gln Leu Asp Asp Phe Met Phe Ile Asp Ser Lys 
        915                 920                 925             


Pro Val Leu Glu Lys Thr Ile Arg Tyr Met Ile Lys Asn Ser Leu Arg 
    930                 935                 940                 


Asp Lys Glu Tyr Gln Gln Arg Val Phe Ile Glu Thr Asn Pro Gly Val 
945                 950                 955                 960 


Phe Lys Ile Pro Tyr Asn Glu Val Val Glu Ala Met Arg Thr Ile Asn 
                965                 970                 975     


His Gln Ala Leu Thr Trp Ala Arg Leu Leu Leu Asp Trp Glu Ser Lys 
            980                 985                 990         


Thr Val Lys Thr Ile Pro Glu Ala  Asp Lys Lys Ala Lys  Leu Gln Glu 
        995                 1000                 1005             


Ala Tyr  Asn Lys Arg Gln Pro  Ala Phe Phe Asn Phe  Asn Asp Ile 
    1010                 1015                 1020             


Cys Arg  Tyr Ala Asp Asp Gly  Lys Gln Leu Lys Asp  Leu Arg Asn 
    1025                 1030                 1035             


Lys Thr  Phe His Thr Glu Val  Pro Glu Thr Trp Thr  Tyr Asp Glu 
    1040                 1045                 1050             


Met Arg  Glu Asn Lys Thr Ile  Lys Met Val Leu Gly  Ile Asn Glu 
    1055                 1060                 1065             


Thr Thr  Phe Leu Lys Lys Asp  Tyr Ala Ile Glu Asn  Ala Arg Thr 
    1070                 1075                 1080             


Ile Glu  
    1085 


<210>  1551
<211>  1008
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1551

Met Asp Thr Pro Asn Phe Ser Glu Arg Ile Pro Val Ser Leu Gln Ser 
1               5                   10                  15      


His Pro Tyr Tyr Phe Ala His Tyr Leu Asn Met Ala Arg His Asn Ala 
            20                  25                  30          


Tyr Val Ile Leu Glu Tyr Val Asn Arg Glu Leu Ile Lys Pro Gly Lys 
        35                  40                  45              


Asn Leu Asp Glu Asp Asn Leu Ile Gln Ser Thr Val Leu Lys Asp Gly 
    50                  55                  60                  


Tyr Phe Asp Arg Lys Pro Asp Glu Leu Ser His Arg Asn Arg Leu Leu 
65                  70                  75                  80  


Val Gln His Phe Pro Phe Leu Arg Glu Ala Glu Asn Glu Gly Ala Arg 
                85                  90                  95      


Thr Cys Asn Pro Val Ser Tyr Lys Leu Lys Thr Ala Leu Ala Ala Leu 
            100                 105                 110         


Asn Gln Trp Arg Asn Asn Ala Ser His Tyr Pro Leu Asn Gln Asn His 
        115                 120                 125             


Glu Lys Asp Phe Asp Leu Gln Pro Phe Phe Ser Phe Ala Ile Glu Ala 
    130                 135                 140                 


Cys Lys Lys Arg Met Arg Glu Val Phe Gln Pro Asp Asp Phe Tyr Leu 
145                 150                 155                 160 


Leu Glu Thr Asn Glu Lys Gln Phe Tyr Thr Leu His Asn Glu Asn Gly 
                165                 170                 175     


Phe Thr Glu Lys Gly Leu Tyr Cys Phe Ile Cys Phe Phe Leu Glu Lys 
            180                 185                 190         


Lys Tyr Ala Phe Gln Phe Leu Ala Gly Ile Lys Gly Phe Lys Asn Thr 
        195                 200                 205             


Thr Asp Asn Lys Phe Arg Ala Thr Leu Glu Thr Phe Thr Glu His Cys 
    210                 215                 220                 


Cys Arg Leu Pro Lys Pro Lys Leu Asp Ser Ser Asp Ile Lys Leu Asp 
225                 230                 235                 240 


Met Leu Gly Glu Leu Ser Arg Cys Pro Ala Pro Leu Phe Asp Leu Leu 
                245                 250                 255     


Asp Ile Glu Glu Arg Lys Lys Phe Ile Arg Glu Pro Glu Glu Val Lys 
            260                 265                 270         


Pro Asp Glu Ser Gly Asp Arg Glu Glu Val Gln Gln Val Leu Met Lys 
        275                 280                 285             


Arg Tyr Asp Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Glu Glu 
    290                 295                 300                 


Lys Asn Leu Leu Lys Gly Ile Ser Phe His Ile His Ile Gly Arg Trp 
305                 310                 315                 320 


Ile Lys Ser Glu His Thr Lys Lys Ile Met Gly Ala Glu Arg Asp Arg 
                325                 330                 335     


Arg Leu Leu Lys Asp Ile Arg Thr Phe Gly Glu Leu Lys Glu Phe Ser 
            340                 345                 350         


Pro Glu His Ala Pro Asp Tyr Trp Leu Arg Asp Gly Ile Thr Pro Asp 
        355                 360                 365             


Asp Val Asp Gln Phe Ser Pro Gln Tyr Arg Ile Val Gly Asn Arg Ile 
    370                 375                 380                 


Gly Ile Lys Leu Asn Tyr Asn Gly His Asn Arg Trp Ser Val Pro Asp 
385                 390                 395                 400 


Lys Glu Ile Asn Val Lys Pro Asp Ala Ile Ile Ser Thr Tyr Glu Phe 
                405                 410                 415     


Leu Asn Leu Phe Leu Tyr Glu His Leu Tyr Gln Lys Lys Leu Thr Gly 
            420                 425                 430         


Leu Ser Pro Ala Glu Phe Ile Gln Asp Tyr Leu Asp Arg Phe Asn Asn 
        435                 440                 445             


Phe Leu Ser Glu Phe Lys Ala Gly His Ile Arg Pro Val Gly Asp Phe 
    450                 455                 460                 


Ser Leu Glu Lys Arg Arg Gly Gln Gly Asp Glu Pro Asp Leu Thr Ala 
465                 470                 475                 480 


Arg Arg Lys Ser Leu Gln Lys Glu Leu Asp Arg Phe Val Leu Lys Gly 
                485                 490                 495     


Lys Asp Leu Pro Asp Lys Ile Arg Glu Tyr Leu Leu Gly Tyr Lys Gln 
            500                 505                 510         


Lys Ser Glu Lys Lys Gln Ala Lys Trp Ile Leu Gly Gly Met Ile Lys 
        515                 520                 525             


Glu Thr Val Tyr Trp Arg Asn Lys Ala Glu Gln Ser Pro Glu Lys Met 
    530                 535                 540                 


Arg Ser Gly Asp Met Ala Gln Gln Leu Ala Arg Asp Ile Ile Phe Leu 
545                 550                 555                 560 


Thr Pro Pro His Thr Val Lys Glu His Lys Gln Lys Leu Asn Ser Leu 
                565                 570                 575     


Glu Tyr Asp Val Leu Gln Tyr Ala Leu Ala Tyr Phe Ser Ser Asn Arg 
            580                 585                 590         


Glu Lys Leu Tyr Ser Phe Phe Lys Glu His Gln Leu Thr Val Lys Gly 
        595                 600                 605             


Asp Arg Ala His Pro Phe Leu Tyr Lys Ile Arg Leu Asp Glu Cys Gln 
    610                 615                 620                 


Gly Ile Leu Asp Phe Phe Ile Val Tyr Met Gln Gln Lys Glu Lys Trp 
625                 630                 635                 640 


Leu Gly Trp Leu Asp Arg Asn Leu Lys Ser Pro Arg Leu Asn Glu Glu 
                645                 650                 655     


Glu Phe Phe Asn Thr Tyr Ser Tyr Phe Ile Lys Thr Asp Thr Lys Arg 
            660                 665                 670         


Ala Ile Glu Met Asp Tyr Glu Ser Cys Pro Asn Tyr Leu Pro Arg Gly 
        675                 680                 685             


Ile Phe Asn Glu Pro Ile Ala Lys Ala Leu Gln Lys Ala Gly Val Lys 
    690                 695                 700                 


Ile Lys Asp Glu Asp Asn Ala Ser Tyr Ala Leu Ser Val Tyr Ser Asn 
705                 710                 715                 720 


Gly Lys Thr Gln Pro Phe Tyr Asn Lys Glu Arg Tyr Tyr Asn Lys Gly 
                725                 730                 735     


Ile Phe Arg Met Glu Glu Leu Pro Glu Lys Leu Gln Pro Lys Glu Leu 
            740                 745                 750         


Leu Gly Lys Ile Gln Trp Thr Ile Lys Ser Ser Gly Lys Asp Thr Glu 
        755                 760                 765             


Glu Phe Arg Ser Leu Gln Asn Leu Lys Asn Arg Ile Leu Asn Thr Glu 
    770                 775                 780                 


Lys Glu Ile Arg Tyr Val Gln Ser Thr Asp Arg Ala Leu Trp Ile Met 
785                 790                 795                 800 


Val Ala Asp Leu Phe Pro Glu Thr Phe Glu Leu Arg Pro Asp Asp Leu 
                805                 810                 815     


Glu Cys Ile Gly His Asp Leu Ser Asp Asp Leu Leu Ser Arg Pro Tyr 
            820                 825                 830         


Gln Met Lys Glu Lys Val Tyr Asn Tyr Thr Ile Thr Asp Tyr Leu Pro 
        835                 840                 845             


Ile Lys Arg Tyr Gly Glu Phe Arg Arg Phe Leu Lys Asp Arg Arg Leu 
    850                 855                 860                 


Glu Asn Leu Leu Thr Tyr Phe Glu Glu Gly Val Pro Leu His Arg Glu 
865                 870                 875                 880 


Ala Leu Val Ala Glu Leu Glu Ala Tyr Asp Leu Gln Arg Lys Asn Leu 
                885                 890                 895     


Leu Glu Ile Ile Tyr Arg Phe Glu Lys Leu Val Phe Asp Arg His Arg 
            900                 905                 910         


His Glu Leu Thr Phe Ser Gly Glu Gly Glu Asn Gln Tyr Val Asn His 
        915                 920                 925             


Trp Asp Tyr Leu Asp Phe Val Ala Arg Lys Tyr Gly Leu Ser Ala Glu 
    930                 935                 940                 


Val Lys Glu Leu Asn Ser Glu Arg Phe Thr Glu Leu Arg Asn Lys Met 
945                 950                 955                 960 


Leu His Asn Gln Ile Pro Tyr Gln Leu Trp Ile Lys Glu Ala Ile Ala 
                965                 970                 975     


Ala Arg Glu Glu Asn Thr Val Cys Gly Arg Ile Met Gly Met Ile Gly 
            980                 985                 990         


Glu Ile Tyr Glu Arg Met Thr Thr  Glu Ile Glu Lys Gln  Met Gln Val 
        995                 1000                 1005             


<210>  1552
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1552

Met Glu Thr Lys Gln Gln Val Gly Lys Gly Ile Ser Tyr Asp His Arg 
1               5                   10                  15      


Arg Pro Asp Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asp Gly Val Ile Gln Glu Phe Ala Met Arg Leu Asn Arg 
        35                  40                  45              


Glu Tyr Asp Pro Glu Asn Lys Asn Gln Ser Leu Phe Ser Tyr Phe Asn 
    50                  55                  60                  


Ile Asn Ala Ser Phe Thr Asp Trp Glu Arg Gly Val Asn Ile Leu Lys 
65                  70                  75                  80  


Glu Tyr Trp Pro Met Met Glu Phe Ile Asp Arg Pro Ala Thr Asp Lys 
                85                  90                  95      


Gln Phe Glu Ala Glu Lys Pro Glu Asn Arg Glu Ala Ala Lys Arg Lys 
            100                 105                 110         


Tyr Phe Leu Ala Thr Leu Gly Ala Leu Leu Thr Ser Ile Lys Asp Leu 
        115                 120                 125             


Arg His Tyr Tyr Thr His Tyr Tyr His Pro Pro Val His Leu Asn Asp 
    130                 135                 140                 


Asp Leu Phe Leu Phe Leu Asp His Ala Leu Leu Tyr Thr Ala Phe Asp 
145                 150                 155                 160 


Val Lys Lys Thr Lys Met Lys Asp Asp Lys Thr Arg Gln Leu Leu Asn 
                165                 170                 175     


Gln Asn Leu Ser Leu Glu Leu Glu Lys Leu Lys Lys Leu Lys Val Glu 
            180                 185                 190         


Glu Leu Lys Lys Lys Lys Glu Lys Gly Ile Lys Val Asn Leu Gln Asp 
        195                 200                 205             


Glu Lys Gly Ile Leu Asn Ala Ile Tyr Asn Asp Ala Phe Ala His Ile 
    210                 215                 220                 


Ile Thr Lys Glu Lys Asp Ser Asp Lys Asp Lys Leu Glu Thr Arg Tyr 
225                 230                 235                 240 


Lys Ser Ile Leu Pro Gln Asp Glu Ala Ala Glu Thr Gly Ile Asn Ile 
                245                 250                 255     


Ser Ile Ser Gly Leu Ile Phe Leu Leu Ser Leu Phe Leu Ser Arg Lys 
            260                 265                 270         


Glu Ile Glu Gln Leu Lys Ser Asn Ile Glu Gly Tyr Lys Gly Lys Val 
        275                 280                 285             


Leu Asn Ile Glu Thr Glu Val Asp Arg Lys His Asn Ser Leu Lys Tyr 
    290                 295                 300                 


Met Ala Thr His Trp Val Phe Ser Ile Leu Ala Phe Lys Gly Leu Lys 
305                 310                 315                 320 


Gln Arg Leu Thr Asn Ser Phe Glu Lys Glu Ser Leu Leu Ile Gln Met 
                325                 330                 335     


Met Asp Glu Leu Asn Lys Val Pro Asp Glu Leu Tyr Gln Thr Leu Ser 
            340                 345                 350         


Glu Thr Ala Lys Lys Glu Phe Leu Glu Asp Ile Asn Glu Tyr Val Ser 
        355                 360                 365             


Glu Gly Asp Asp Asn Glu Lys Ala Thr Tyr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Ser Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gln Phe Pro Thr Leu Lys Phe Gln Ile Phe Val Gly 
                405                 410                 415     


Gln Tyr Leu His Asp Asn Arg Pro Lys Thr Leu Ala Ser Asn Gly Met 
            420                 425                 430         


Thr Ala Gln Arg Met Ile Lys Glu Lys Ile Asn Leu Phe Gly Asn Leu 
        435                 440                 445             


Ser Glu Val Thr Lys His Lys Ser Asp Phe Phe Glu Lys Glu Ser Ala 
    450                 455                 460                 


Ala Gln Gly Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Trp Ala Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Val Tyr Ile Asp Met Ile Gly Lys Glu Gly Lys Ala 
                485                 490                 495     


Lys Glu Ile Gln Val Gln Ile Asn Lys Tyr Arg Lys Gln Leu Asn Pro 
            500                 505                 510         


Ala Pro Gln Arg Asp Lys Arg Ile Ser Lys Lys Glu Ile Ile Glu Gln 
        515                 520                 525             


Leu Tyr Lys Glu Lys Val Val Tyr Gly Asp Pro Thr Leu Met Leu Ser 
    530                 535                 540                 


Ala Asn Glu Leu Met Ala Leu Leu Tyr Glu Leu Ile Val Asn Gly Lys 
545                 550                 555                 560 


Ser Gly Ala Glu Leu Glu Asn Lys Ile Val Glu Gln Ile Ile Ala Arg 
                565                 570                 575     


Tyr Glu Gln Ile Glu Ala Tyr Asp Pro Thr Thr Gln Gln Leu Pro Thr 
            580                 585                 590         


Asn Gln Met Pro His Lys Leu Gln Lys Ser Arg Lys Asp Ser Lys Val 
        595                 600                 605             


Thr Asp Thr Asp Lys Leu Leu Lys Thr Ile Asp Lys Glu Ile Asp Glu 
    610                 615                 620                 


Gly Asn Lys Lys Leu Glu Leu Ile Ala Cys His Arg Lys Glu Trp Glu 
625                 630                 635                 640 


Glu Ala Glu Gln Arg Lys Lys Ser Gly Lys Arg Asn Asn Pro Gly Thr 
                645                 650                 655     


Lys Ser Arg Lys His Leu Phe Tyr Ala Ser Glu Met Gly Glu Glu Ala 
            660                 665                 670         


Thr Trp Ile Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Pro Ala Arg 
        675                 680                 685             


Ala Glu Trp Lys Gly Thr His His Ser Glu Leu Gln Arg Leu Leu Ala 
    690                 695                 700                 


Phe Tyr Ser Thr Gln Arg Leu Glu Ala Trp Gln Leu Val Glu Ser Val 
705                 710                 715                 720 


Trp Thr Ala Asn Thr His Ser Phe Trp Glu Glu Asn Phe Lys Glu Ala 
                725                 730                 735     


Phe Tyr Lys Pro Glu Phe Glu Asn Phe Tyr Gly Ala Tyr Ile Glu Ile 
            740                 745                 750         


Arg Thr Lys Ile Leu Thr Thr Cys Arg Ser Ile Leu Glu Asn Asn Pro 
        755                 760                 765             


Glu Ala Thr Met Asn Asn Asp Thr Glu Lys Glu Trp Asp Lys Val Phe 
    770                 775                 780                 


Thr Leu Phe Asp Lys Arg Leu Tyr Arg Thr Ser Thr Thr Asp Glu Gln 
785                 790                 795                 800 


Lys Lys Gln Leu Leu Thr Lys Pro Phe Ala Phe Pro Arg Gly Leu Phe 
                805                 810                 815     


Asp Asp Lys Pro Thr Phe Leu Pro Gly Ser Lys Pro Asn Glu Asn Pro 
            820                 825                 830         


Glu Arg Phe Ala Ala Trp Tyr Ser Tyr Gly Tyr Thr Tyr Ser Gly Lys 
        835                 840                 845             


Phe Gln Ser Phe Tyr Asp Met Pro Arg Asn Tyr Ser Asp Trp Tyr Lys 
    850                 855                 860                 


Lys Leu Lys Glu Asp Gly Lys Leu Pro Arg Leu Asp Lys Lys Thr Glu 
865                 870                 875                 880 


Gln Glu Lys Ile Leu Arg Phe Arg Met Asp Cys Asp Leu Asn Ile Lys 
                885                 890                 895     


His Ile Arg Phe Gln Asp Ile Tyr Val Lys Leu Met Val Asp Ser Leu 
            900                 905                 910         


Tyr Lys Ala Val Phe Gly Gln Gln Pro Glu Phe Asp Leu Ser His Leu 
        915                 920                 925             


Tyr Asp Thr Arg Ser Glu Arg Tyr Glu Asn Asn Thr Ile Ala Gln Arg 
    930                 935                 940                 


Gln Lys Ser Arg Gln Glu Gly Asp Asn Ser Asp Asn Ala Ile Asn Glu 
945                 950                 955                 960 


Asn Tyr Val Trp Asn Lys Thr Phe Ala Ile Ser Leu Tyr Asn Gly Arg 
                965                 970                 975     


Ile Thr Glu Ser Gln Val Lys Leu Lys Asp Val Gly Lys Phe Arg Arg 
            980                 985                 990         


Phe Ala Thr Asp Pro Arg Val Gln  Thr Leu Ile Ser Tyr  Asp Asp Thr 
        995                 1000                 1005             


Arg Thr  Trp Thr Lys Leu Glu  Ile Glu Asn Glu Leu  Asp Asn Lys 
    1010                 1015                 1020             


Ala Asp  Ala Tyr Glu Pro Ile  Arg Arg Thr Gln Ser  Leu Lys Ala 
    1025                 1030                 1035             


Ile Gln  Gln Leu Glu Lys Asn  Ile Leu Lys Lys Asn  Gly Phe Asn 
    1040                 1045                 1050             


Gly Lys  Gln His Pro Glu Glu  Leu Lys His Asn Gly  Asn Pro Asn 
    1055                 1060                 1065             


Phe Arg  Lys Tyr Ile Ala Asn  Gly Leu Leu Lys His  Arg Thr Asp 
    1070                 1075                 1080             


Ile Arg  Gln Glu Glu Leu Ala  Leu Ile Ser Asp Thr  Glu Phe Gln 
    1085                 1090                 1095             


Glu Ile  Gly Leu Glu Arg Ile  Arg Gln Thr Asn Pro  Leu Ile Gln 
    1100                 1105                 1110             


Lys Ala  Tyr Leu Leu Ile Leu  Leu Arg Asn Lys Phe  Gly His Asn 
    1115                 1120                 1125             


Gln Leu  Pro Asp Gln Glu His  Phe Arg Leu Met Arg  Ser Ile Tyr 
    1130                 1135                 1140             


Pro Tyr  Asn Gln Gln Glu Ser  Tyr Ser Ala Tyr Phe  Asn His Val 
    1145                 1150                 1155             


Ile Thr  Gln Ile Ile Glu Glu  Leu Asn Thr 
    1160                 1165             


<210>  1553
<211>  1140
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1553

Met Glu Asn Asp Gln Gln Ile Leu Glu Asn Arg Arg Arg Thr Leu Ala 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Ser Asn His Leu Ala Ala Ser Phe Glu Gln Lys Val 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ala Ser Phe Leu Cys Asn Lys Ser 
    50                  55                  60                  


Ile Lys Lys Ile Asn Trp Asn His Val Tyr Ser Lys Ala Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ala Asp Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Arg Glu Thr Thr Asp Lys Glu Gly Lys Asp Phe Thr Ala Met Asn Glu 
            100                 105                 110         


Thr Leu Lys Leu Val Phe Asp Glu Leu Gln Ala Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Ala Asp Ser Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Val Glu Leu Ala Asp Phe Leu Thr Val Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Ala Asp Asp Asp Tyr 
                165                 170                 175     


Thr Met Val Glu Ser Lys Gln Ile Val Thr Pro Asp Asn Leu Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Val Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Leu Ala Tyr Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asp Leu Gly Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Glu 
            260                 265                 270         


Val Ile Thr Glu Glu Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Glu Glu Glu Arg 
    290                 295                 300                 


Glu Lys Ile Leu Asp Glu Ile Asp Tyr Glu Asp Tyr Ile Glu Ser Leu 
305                 310                 315                 320 


Thr Arg Arg Val Arg His Ser Asn Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Lys Tyr Asn Lys Gln Phe Asp Gly Glu 
        355                 360                 365             


Ala Thr Glu Cys Lys Val Val Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asn Gln Glu Thr Val Glu Leu Lys Ile Asp Ser Ala 
385                 390                 395                 400 


Gln Arg Thr Asn Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Glu Ala Arg Leu Leu 
            420                 425                 430         


Thr Lys Ala Lys Pro Glu Ser Lys Val Ser Tyr Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Lys Ala Glu Glu Met Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Lys Val Asn Asp Ser Gln Leu Met Ser Met Gln Phe Ile Asp Glu 
                485                 490                 495     


Ile Lys Glu Gln Leu Pro Ala Asp Trp Asn Glu Phe Gly Lys Arg Ser 
            500                 505                 510         


Asp Ser Lys Lys Lys Lys Ala Tyr Thr Asn Ala Ala Leu Gln Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Lys Val Leu Ala Asn Tyr Gln Leu 
    530                 535                 540                 


Asn Asp Lys Gln Val Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Ser Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Val Glu Lys His Lys Leu 
            580                 585                 590         


Asp Lys Ser Ala Arg Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Thr Asp Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Phe Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Tyr 
625                 630                 635                 640 


Ala Asp Thr Asp Lys Lys Ala Thr Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Lys Gly Gly His Pro Phe Leu Ala Asn Ile Asn 
            660                 665                 670         


Leu Arg Gln Ile Arg Lys Thr Ser Gln Leu Tyr Glu Leu Tyr Leu Val 
        675                 680                 685             


Glu Lys Ala Asn Lys Gln Val Lys Lys Met Asn Pro Lys Thr Gln Arg 
    690                 695                 700                 


Thr Ser Asn Val Asp Glu Ser Trp Met Met Lys Ser Phe Tyr Ala Lys 
705                 710                 715                 720 


Glu Trp Asn Glu Glu Met Gly Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Val Asn Lys Thr Asn Ile Pro Phe Thr Ile Arg Gln Trp Glu Glu Lys 
            740                 745                 750         


Glu Lys His Asn Leu Gln Ala Trp Leu His Asn Ile Thr Lys Gly Lys 
        755                 760                 765             


Thr Ser Lys Asp Gly Lys Lys Ala Ile Asp Leu Pro Thr Asn Leu Phe 
    770                 775                 780                 


Asp Asp Thr Leu Cys Glu Leu Leu Arg Glu Ala Leu Ile Asn Gln Gly 
785                 790                 795                 800 


Ile Asp Ala Thr Pro Thr Thr Lys Tyr Asn Glu Leu Leu Lys Gln Trp 
                805                 810                 815     


Trp Thr Ala Arg Glu Asp Ser Thr Gln Asp Phe Tyr Leu Ser Glu Arg 
            820                 825                 830         


Gln Tyr Asp Ile Tyr Asp Glu Lys Val Cys Phe Thr Ile Asn Ser Ser 
        835                 840                 845             


Ala His Phe Ala Asp Tyr Tyr Ala Pro Ala Leu Asn Lys Ala Tyr Ser 
    850                 855                 860                 


Arg Leu Arg Ala Glu Arg Asp Val Ala Arg Arg Thr Asp Lys Arg Leu 
865                 870                 875                 880 


Pro Pro Val Glu Arg Lys Asp Val Glu Arg Val Phe Lys Asn Thr Ile 
                885                 890                 895     


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
            900                 905                 910         


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asn Gln Gln Gln Leu Lys 
        915                 920                 925             


Leu Ser Lys Met Asp Ser Leu Leu Asn Glu Thr Lys Arg Ile Glu Gln 
    930                 935                 940                 


Thr Ile Asn Thr Gln Leu Ser Phe Asp His Lys Gly Lys Glu Ile Lys 
945                 950                 955                 960 


Asp Lys Thr Asn Ser Glu Ile Val Lys Thr Ile Val Ala Glu Arg Lys 
                965                 970                 975     


Gln Lys Asn Tyr Thr Glu Met Arg Lys Tyr Val His Asp Arg Arg Leu 
            980                 985                 990         


Pro Glu Leu Phe Glu Tyr Ile Asp  Gly Asn Glu Leu Pro  Leu Asp Val 
        995                 1000                 1005             


Leu Leu  Asn Glu Leu Arg Ala  Tyr Asn Thr Ala Lys  Gln Met Val 
    1010                 1015                 1020             


Phe Asp  Thr Val Phe Ala Leu  Glu Lys Lys Ile Ile  Glu Thr Asp 
    1025                 1030                 1035             


Pro Glu  Gly Leu Lys Gln Leu  Asn Val Gly Lys Asn  Gly Gln Ile 
    1040                 1045                 1050             


Gln Thr  Gly Asn Ile Gln His  Lys Pro Tyr Val Gln  Trp Leu Glu 
    1055                 1060                 1065             


Asn Lys  Gly Leu Ile Thr Asp  His Gln Lys Gln Phe  Ile Asn Met 
    1070                 1075                 1080             


Val Arg  Asn Ser Phe Ser His  Asn Gln Phe Pro Gln  Arg Ser Thr 
    1085                 1090                 1095             


Val Glu  Leu Leu Met Pro Glu  Trp Gln Asn Thr Asp  Ile Ala Leu 
    1100                 1105                 1110             


Gln Ile  Ala Arg Glu Tyr Gln  Gln Leu Ile Val Asp  Ile Ile Glu 
    1115                 1120                 1125             


Lys Ser  Leu His Pro His Lys  Gln His Gln Met Val  
    1130                 1135                 1140 


<210>  1554
<211>  1199
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1554

Met Asn Thr Phe Ile Asp Ser Phe Ile Arg Arg Val Gln Ile Gln Asn 
1               5                   10                  15      


Gln Asn Gln Ser Trp Pro Lys Arg Pro Lys Tyr Val Arg Pro Val Glu 
            20                  25                  30          


Asn Ile Arg Pro Asp Asp Leu Ala Phe Gln Ser His Phe Thr Ala Tyr 
        35                  40                  45              


Leu Asn Met Ala Arg Gln Asn Cys Cys Ile Ile Leu Gly His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Gly Phe Lys Ala Ser Ser Val Lys Asp Thr Thr Leu Thr 
65                  70                  75                  80  


Ser Ser Pro Leu Leu Gly Gln Asn Gly Leu Leu Ser Pro Lys Lys Glu 
                85                  90                  95      


Val Ser Asp Leu Ile Arg Gly Arg Leu Leu Ser Ala Phe Pro Met Leu 
            100                 105                 110         


Asp Pro Met Ile Arg Tyr Arg Lys Ala Val Asp Lys Glu Lys Asp Asp 
        115                 120                 125             


Tyr Ala Arg Ile Ile Ile Thr Ser Glu Asp Val Ser Glu Met Leu Arg 
    130                 135                 140                 


Asp Leu Leu Asp Val Leu Ser Tyr Tyr Arg Asp Met Ala Ser His Val 
145                 150                 155                 160 


Val Phe Asn Asp Asp Arg Ser Val Ser Ala Glu Phe Ala Ser Lys Glu 
                165                 170                 175     


Lys Lys Val Ala Glu Cys Leu Asn Tyr Met Met Thr Val Ser Leu Arg 
            180                 185                 190         


Ile Val Lys Asp Arg Phe Ser Leu Ala Val Ser Asp Leu Asp Phe Tyr 
        195                 200                 205             


Asn Arg Asn Arg Tyr Met Met Val Asn Arg Lys Pro Leu Leu Asn Ala 
    210                 215                 220                 


Gly Phe Ala His Ala Val Arg Thr Glu Asp Tyr Arg Leu Thr Leu Met 
225                 230                 235                 240 


Gly Leu Val Leu Leu Cys Cys Gln Phe Ile Glu Lys Gln Tyr Ala Ser 
                245                 250                 255     


Met Phe Phe Asp Ala Leu Asp Lys His Ser Asn Gly Ala Arg Phe Tyr 
            260                 265                 270         


Gly Ile Ala Asp Ala Met Pro Met Val Asn Val Gly Thr Lys Asp Lys 
        275                 280                 285             


Pro Lys Lys Ile Pro Met Tyr Thr Gly Asp Glu Ala Gln Lys Gln Val 
    290                 295                 300                 


Gln Lys Gln Arg Met Ala Leu Arg Glu Ala Tyr Ser Val Tyr Arg Val 
305                 310                 315                 320 


Arg Ile Pro Lys Glu Arg Leu Glu Ser Thr Arg Ser Asp Met Ala Leu 
                325                 330                 335     


Ala Leu Asp Ile Leu Asn Glu Leu Gly Lys Cys Pro Glu Glu Leu Phe 
            340                 345                 350         


Glu His Leu Ser Pro Glu Asp Arg Glu Ser Phe Lys Asn Glu Glu Gly 
        355                 360                 365             


Val Leu Met Lys Arg Tyr Ser Asp Arg Phe Pro Gln Leu Ala Leu Arg 
    370                 375                 380                 


Trp Leu Asp Glu Asn Glu Lys Phe Asn Asn Leu Arg Phe His Val Thr 
385                 390                 395                 400 


Phe Gly Lys Tyr Arg Trp Leu Phe Cys Gln Asp Lys Lys Cys Ala Asp 
                405                 410                 415     


Gly Ser Val Arg Pro Arg Trp Leu Gln Lys Glu Leu Asn Gly Phe Gly 
            420                 425                 430         


Arg Ile Gln Thr Val Glu Arg Lys Arg Thr Gly Leu Glu Pro Gly Trp 
        435                 440                 445             


Asp Gly Thr Gly Leu Ile Arg Lys Phe Glu Glu Val Val Thr Asp Glu 
    450                 455                 460                 


Val Gln Lys Glu Pro Tyr Ile Thr Asp Phe Arg Thr Gln Tyr Leu Phe 
465                 470                 475                 480 


Asn Arg Asp Lys Ile Gly Ile Ser Leu Ser Glu Tyr Met Pro Gly Ile 
                485                 490                 495     


Gly Asp Ile His Ser Gly Lys Glu Trp Gly Lys His Ala Gly Val Pro 
            500                 505                 510         


Asp Phe Tyr Leu Ser Val Tyr Asp Ile Pro Ala Met Leu Phe Leu Thr 
        515                 520                 525             


Trp Leu Leu Gly Lys Asn Ser Ser Ala Val Glu Lys Leu Leu Ala Asn 
    530                 535                 540                 


Cys Lys Ala Ala Tyr Met Lys Leu Phe Asp Asp Leu Ala Lys Gly Lys 
545                 550                 555                 560 


Trp Glu Gly Glu Arg Asn Val Ser Asp Tyr Cys Ala Gly Glu Gly Thr 
                565                 570                 575     


Val Arg Tyr Thr Leu Arg Trp Tyr Asp Val Pro Met Lys Ile Arg Arg 
            580                 585                 590         


Lys Met Pro Leu Leu Gly Gly Asp Arg Asp Phe Glu Glu Lys Lys Ser 
        595                 600                 605             


Phe Glu Thr Leu Ala Gln Glu Ala Leu Thr Arg Met Leu Gln Arg Thr 
    610                 615                 620                 


Glu Asn Gln Leu Glu Lys Phe Asp Arg Asp Leu Ala Ala Ala Arg Asp 
625                 630                 635                 640 


Leu Lys Ala Asn Lys Gln Gly Lys Asp Arg Phe Val Asp Ile Arg Ala 
                645                 650                 655     


Gly Ser Leu Ala Thr Phe Leu Ala Arg Asp Ile Val Arg Leu Met Pro 
            660                 665                 670         


Val Ser Asp Asn Gly Arg Asn Lys Pro Thr Gly Leu Asn Tyr Ser Ile 
        675                 680                 685             


Val Gln Lys Ala Ile Ala Thr Tyr Lys Pro Ser Glu Gly Gly Leu Asp 
    690                 695                 700                 


Thr Leu Thr Gly Val Phe Arg Asp Ala Arg Ile Ile Gly Val Lys Gly 
705                 710                 715                 720 


Gly Ser His Pro Phe Leu Glu Arg Leu Leu Val Glu Lys Lys Pro Ser 
                725                 730                 735     


Ser Val Leu Ala Leu Tyr Arg His Tyr Leu Glu Tyr Arg Lys Glu Tyr 
            740                 745                 750         


Leu Lys Lys Ala Leu Glu Asp Glu Asn Lys Ala Glu Leu Lys Asn Leu 
        755                 760                 765             


Pro Phe Leu Lys Ser Gly Arg Gln Lys Tyr Ala Val Asp Gln Ala Asp 
    770                 775                 780                 


Tyr Ala Arg Arg Leu Ala Glu Ser Tyr Arg Asn Cys Pro Ile Tyr Leu 
785                 790                 795                 800 


Pro Thr Gly Ile Phe Thr Asp Met Leu Lys Asp Gln Leu Ala Lys Ile 
                805                 810                 815     


Asp Val Met Lys Pro Val Leu Glu Asn Asp Lys Val Asn Ala Ser Tyr 
            820                 825                 830         


Leu Ile Ala Gln Tyr Phe Glu Lys Val Glu His Asp Ser Glu Gln Pro 
        835                 840                 845             


Leu Tyr Arg Leu Lys Arg Asn Tyr Arg Val Phe Asp Leu Leu Glu Phe 
    850                 855                 860                 


Thr Asp Glu Pro Lys Tyr Trp Arg Leu Asn Glu Arg Ser Asp Lys Ala 
865                 870                 875                 880 


Gly Lys Tyr Gly Leu Ala Lys Arg Asn Ile Phe Trp Asn Arg Met Gly 
                885                 890                 895     


Glu Tyr Tyr Lys Gly Leu Lys Lys Phe Tyr Lys Gly Tyr Glu Ser Lys 
            900                 905                 910         


Arg Thr Ala Val Asp Trp Arg Glu Lys Leu Lys Ile Val Glu Ala Glu 
        915                 920                 925             


His Ala Met Trp Asn Arg Leu Lys Asp Ala Ser Gly Glu Ala Arg Leu 
    930                 935                 940                 


Lys Met Lys Asp Gly Val Phe Tyr Ser Arg Leu Leu Ser Ala Arg Lys 
945                 950                 955                 960 


Glu Tyr Asp Asp Cys Glu Arg Ala Leu Arg Arg Leu Lys Val Gln Asp 
                965                 970                 975     


Ile Val Leu Phe Leu Ala Ala Arg Glu Thr Leu Ile Leu Pro Lys Asp 
            980                 985                 990         


Lys Val Phe Arg Leu Lys Asn Leu  Ser Leu Ser Glu Gly  Asn Lys Asn 
        995                 1000                 1005             


Ile Leu  Ser Ser Ala Ile Asp  Glu Phe Ser Val Asp  Val Val Trp 
    1010                 1015                 1020             


Thr Glu  Lys Glu Gly Ala Ala  Lys Val Thr His Ser  Ala Ser Ile 
    1025                 1030                 1035             


Lys Glu  Asn Asp Val Val Ile  Lys Asn Tyr Gly Arg  Met Phe Arg 
    1040                 1045                 1050             


Leu Leu  His Asp Asp Arg Val  Lys Thr Leu Leu Pro  His Ile Tyr 
    1055                 1060                 1065             


Asp Ser  Ala Leu Ser Glu Asn  Ile Thr Gly Asp Arg  Ile Thr Val 
    1070                 1075                 1080             


Lys Asp  Asn Lys Val Ile Ile  Asp Lys Ser Leu Phe  Asp Glu Asp 
    1085                 1090                 1095             


Leu Met  Asn Tyr Asp Leu Arg  Arg His Glu Ile Cys  Glu Ile Ile 
    1100                 1105                 1110             


Leu Arg  Phe Glu Ala Ala Ser  Ile Lys Arg Phe Gly  Leu Asp Gly 
    1115                 1120                 1125             


Arg Val  Asp Phe Lys Ala Ala  Leu Asp Ala Leu Thr  Gly Arg Ser 
    1130                 1135                 1140             


Leu Leu  Asn Asp Glu Asp Ala  Arg Ile Leu Ser Ala  Ile Arg Asn 
    1145                 1150                 1155             


Ala Tyr  Asn His Asn Lys Tyr  Pro Ala Lys Gly Thr  Asp Val Lys 
    1160                 1165                 1170             


Val Asn  Val Met Ala Leu Pro  Lys Leu Thr Glu Asp  Leu Leu Arg 
    1175                 1180                 1185             


Ile Phe  Ser Asp Thr Gly Asn  Asn Arg Val Arg 
    1190                 1195                 


<210>  1555
<211>  1094
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1555

Met Glu Ala Asn Glu Gln Asn Gln Glu Asn Arg Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Asn Asn His Ile Ala Ala Asp Phe Gly Gln Ala Val 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ser Gly Phe Leu Cys Asn Lys Glu 
    50                  55                  60                  


Ile Lys Lys Leu Asn Trp Asn His Ile Tyr Ala Lys Thr Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ile Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Val Asn Ser Asp Lys Glu Gly Lys Asp Phe Ala Ala Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Ser Glu Leu Gln Asp Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Glu Asn Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Ala Glu Leu Thr Asp Met Leu Thr Ile Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Thr Asp Ala Asp Tyr 
                165                 170                 175     


Glu Leu Val Glu Thr Lys Gln Val Val Thr Thr Gly Asn Ile Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Met Phe Leu Glu Arg Glu His 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asn Leu Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Gly 
            260                 265                 270         


Val Ile Thr Asp Glu Glu Lys Met Gln Phe Arg Pro Glu Leu Asp Glu 
        275                 280                 285             


Leu Asp Ile Glu Lys Leu Ile Ala Asn Ser Thr Asn Asp Asp Glu Arg 
    290                 295                 300                 


Glu Arg Ile Leu Asp Glu Ile Gly Tyr Glu Glu Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg Tyr Asn Asn Arg Phe Pro Tyr Phe Ala Met Arg 
                325                 330                 335     


Phe Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Arg Tyr Thr Lys Gln Leu Ala Gly Glu 
        355                 360                 365             


Gln Thr Glu Arg Val Val Gln Glu Asn Val Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asp Pro Glu Leu Ile Gln Gln Lys Ile Asp Asn Gln 
385                 390                 395                 400 


Gln Arg Thr Asp Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Ile Ala Ile Leu Ile 
            420                 425                 430         


Pro Lys Ser Lys Pro Glu Ser Lys Val Gly Asn Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Asp Tyr Leu Gln Lys Gly Lys Ala Glu Glu Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Ile Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Leu Lys Leu Pro Ala Asn Trp Asn Glu Phe Ala Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asp Ala Ala Met Glu Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Asp Val Leu Ile Thr Tyr Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Asp Val Glu Asp Asn Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Leu Glu Lys His Lys Leu 
            580                 585                 590         


Asp Lys Ser Val Lys Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Met Val Ser Lys Glu Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Ala Asp Thr Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Val Leu Glu Gly Asp Gly His Pro Phe Leu Thr Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Glu Leu Tyr Met Asn 
        675                 680                 685             


Ala Lys Val Gln Tyr Leu Ile Gln Phe Tyr Lys Pro Ser Lys Asp Lys 
    690                 695                 700                 


Val Asp Lys Arg Gly Arg Pro Thr Thr Glu Val Lys Leu Pro Pro Leu 
705                 710                 715                 720 


Asp Lys Arg Ser Asn Ile Pro Phe Thr Ile Arg Gln Trp Asp Glu Lys 
                725                 730                 735     


Glu Lys Tyr Asn Leu Asn Ala Trp Leu Arg Asn Val Thr Val Gly Lys 
            740                 745                 750         


Asn Thr Lys Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe 
        755                 760                 765             


Asp Glu Thr Leu Cys Asp Leu Leu Ser Gln Gln Leu Asp Ala Arg Thr 
    770                 775                 780                 


Val Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Leu Trp 
785                 790                 795                 800 


Trp Lys Thr Arg Asp Asp Ala Thr Gln Asp Phe Tyr Gln Ser Glu Arg 
                805                 810                 815     


Glu Tyr Asp Ile Tyr Glu Glu Lys Val Glu Phe Lys Ile Asp Ser Ser 
            820                 825                 830         


Gly His Phe Ala Asp Tyr Tyr Lys Lys Ala Leu Ser Lys Ala Tyr Asn 
        835                 840                 845             


Arg Leu Lys Ala Glu Arg Glu Ile Ala Arg Arg Thr Asn Lys Arg Leu 
    850                 855                 860                 


Pro Pro Ile Glu His Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile 
865                 870                 875                 880 


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
                885                 890                 895     


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asp Ser Gly Asn Leu Lys 
            900                 905                 910         


Leu Ser Thr Ile Lys Thr Ser Leu Asn Asn Thr Thr Gln Ile Lys Gln 
        915                 920                 925             


Lys Ile Leu Asn Lys Thr Ile Val Ala Glu Arg Lys Gln Lys Asn Tyr 
    930                 935                 940                 


Thr Glu Leu Arg Lys Tyr Val His Asp Arg Arg Leu Pro Asn Leu Phe 
945                 950                 955                 960 


Glu Tyr Val Glu Ala Asp Glu Ile Leu Leu Glu Trp Leu Leu Asp Glu 
                965                 970                 975     


Leu Met Ala Tyr Asn Ala Ala Lys Gln Gln Val Phe Asp Thr Ile Phe 
            980                 985                 990         


Met Leu Glu Lys Arg Ile Ile Glu  Thr Asp Pro Gln Glu  Leu Lys Ser 
        995                 1000                 1005             


Leu Phe  Thr Asn Glu Lys Gly  Gln Val Gln Thr Gly  Asn Ile Gln 
    1010                 1015                 1020             


His Lys  Pro Tyr Val Gln Trp  Leu Lys Asn Lys Gly  Leu Ile Asn 
    1025                 1030                 1035             


His Asn  Glu Lys Leu Phe Ile  Asn Met Val Arg Asn  Cys Phe Ser 
    1040                 1045                 1050             


His Asn  Gln Phe Pro Gln Arg  Glu Thr Met Glu Leu  Leu Ile Ser 
    1055                 1060                 1065             


Glu Trp  Gly Ala Gly Lys Ile  Ala Thr Gln Ile Leu  Thr Val Tyr 
    1070                 1075                 1080             


Asn Gln  Leu Ile Thr Asn Ile  Ile Asn Lys Ile 
    1085                 1090                 


<210>  1556
<211>  1047
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1556

Met Glu Glu Gln Phe Leu Gln Lys Glu Arg Asn Met Gly Asp Asn Pro 
1               5                   10                  15      


Tyr Tyr Phe Cys His Phe Ile Asn Met Ala His His Asn Val Asn Leu 
            20                  25                  30          


Ile Leu Glu Glu Ile Tyr Asn Ser Val Tyr Glu Lys Tyr Thr Gln Asp 
        35                  40                  45              


Lys Glu Glu Asn Ile Lys Ala Ile Cys Asn Ser Met Ile Ser Lys Ser 
    50                  55                  60                  


Arg Lys Asn Pro Asp Glu Lys Ala Lys Met Met Asn Met Cys Ile Arg 
65                  70                  75                  80  


His Phe Pro Phe Leu Asp Tyr Tyr Lys Glu Lys Asp Gln Asn Ser Asp 
                85                  90                  95      


Val Leu Thr Ile Leu Leu Asn Gln Phe Leu Val Pro Leu His Gly Leu 
            100                 105                 110         


Arg Asn Gln Phe Ser His Tyr Lys His Pro Gln Glu Ala Tyr Cys Ile 
        115                 120                 125             


Ser Gly Phe Asp Leu Leu Phe Glu Gln Ala Lys Thr Gly Ala Gln Met 
    130                 135                 140                 


Arg Met Lys Tyr Ser Asp Glu Asp Ile Ser Lys Val Lys Ser Lys Val 
145                 150                 155                 160 


Val Asn His Asp Ser Ile Leu Thr Glu Arg Gly Ile Leu Phe Phe Ile 
                165                 170                 175     


Cys Leu Phe Leu Asp Lys Arg Asn Ile Tyr Leu Phe Leu Ser Lys Ile 
            180                 185                 190         


Lys Gly Phe Arg Asp Arg Arg Pro Asp Glu Lys Tyr Lys Ser Ala Thr 
        195                 200                 205             


Leu Glu Val Phe Ser Gln Tyr Tyr Cys His Val Pro Tyr Arg Lys Leu 
    210                 215                 220                 


Asp Ser Ser Asp Val Ala Leu Asp Met Leu Asn Glu Leu Asn Arg Cys 
225                 230                 235                 240 


Pro Lys Ala Leu Tyr Asp Val Leu Ser Asp Glu Asp Arg Glu Arg Phe 
                245                 250                 255     


Ile Val Asp Asn Val Glu Asn Ala Asp Asn Arg Asp Glu Ile Ser Asp 
            260                 265                 270         


Glu Asp Asp Glu Glu Met Pro Arg Ser Val Met Lys Arg Ser Asp Asp 
        275                 280                 285             


Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Glu Lys Gln Asn Asn Leu 
    290                 295                 300                 


Asp Glu Ile Ser Phe His Leu Tyr Leu Gly Arg Lys Glu Ala Lys Pro 
305                 310                 315                 320 


Ala His Glu Lys Val Ile Asn Gly Glu Met Arg Thr His Lys Ile Leu 
                325                 330                 335     


Lys Asp Ile His Val Phe Gly Arg Leu Glu Asn Tyr Arg Asn Glu Glu 
            340                 345                 350         


Ile Cys Asn Ala Ile Lys Asn Arg Glu Asp Ile Glu Phe Tyr Ala Pro 
        355                 360                 365             


Ser Tyr Arg Ile Val Glu Asn Arg Ile Gly Leu Leu Leu Arg Arg Gln 
    370                 375                 380                 


Asn Asp Phe Thr Leu Glu Glu Ala Asn Glu Glu Lys Ile Phe Glu Gly 
385                 390                 395                 400 


Asn Leu Cys Pro Asp Val Ile Leu Ser Thr His Glu Leu Gly Ala Leu 
                405                 410                 415     


Phe Phe Tyr Asn Tyr Leu His Lys Lys Gly Trp Ile Glu Ser Ala Pro 
            420                 425                 430         


Tyr Leu Tyr Ile Arg Asn Phe Ile Ser Asp Phe Lys Arg Phe Ile Glu 
        435                 440                 445             


Asp Ile Lys Asn Gly Lys Leu Thr Pro Val Glu Ser Glu Asp Asp Phe 
    450                 455                 460                 


Tyr Leu Ile Lys Lys Lys Lys Arg Asp Glu Thr Lys Asp Asn Asp Lys 
465                 470                 475                 480 


Lys Ser Ile Ala Val Gln Glu Arg Arg Arg Glu Lys Leu Lys Glu Lys 
                485                 490                 495     


Leu Lys Gly Tyr His Leu Glu Pro Asp Trp Ile Pro Asp Ala Cys Arg 
            500                 505                 510         


Glu Tyr Met Leu Gly Tyr Lys Ala Asp Gln Lys Asp Tyr Tyr Thr Lys 
        515                 520                 525             


Gln Arg Phe Cys Ser Met Lys Lys Glu Thr Asp Ser Arg Ile Lys Gln 
    530                 535                 540                 


Ile Glu Ala Ile Arg Lys Arg Glu Asp Asn Ser Ile Ile Arg Gln Thr 
545                 550                 555                 560 


Arg Val Gly Glu Ile Ala Gln Glu Leu Ala Arg Asp Ile Val Phe Leu 
                565                 570                 575     


Ile Pro Pro Tyr Lys Asn Glu Lys Gly Ala Asp Thr Lys Ile Asn Asn 
            580                 585                 590         


Met Glu Phe Asp Val Leu Gln Lys Met Leu Ala Tyr Phe Pro Leu Asn 
        595                 600                 605             


Lys Lys Asp Ile Tyr Pro Phe Leu Lys Asn Ile Arg Asn Trp Asp Lys 
    610                 615                 620                 


His Pro Phe Leu Lys Tyr Thr Leu His Thr Glu His Gln Ser Leu Leu 
625                 630                 635                 640 


Asp Phe Tyr Gln Asp Tyr Leu Asn Cys Lys Lys Arg Trp Ile Ser Lys 
                645                 650                 655     


Asn Ile Arg Tyr Asp Lys Gln Lys Gly Asn Tyr Leu Val Asp Ala Asn 
            660                 665                 670         


Lys Thr Glu Gln Glu Cys Arg Tyr Phe Leu Lys Thr Asp Lys Leu Arg 
        675                 680                 685             


Thr Ala Lys Glu Lys Glu Tyr Phe Glu Glu Pro Asp Lys Pro Val Tyr 
    690                 695                 700                 


Leu Pro Thr Gly Phe Phe Val Asp Pro Ile Val Glu Ala Met Arg Lys 
705                 710                 715                 720 


Asn Gly Tyr Glu Leu Lys Glu Asn Ser Asn Ile Val Gly Cys Leu Lys 
                725                 730                 735     


Ile Tyr Phe Val Ser Lys Ile Gln Pro Met Tyr Asp Leu Ser Arg Tyr 
            740                 745                 750         


Tyr Thr Tyr Tyr Asp Gly Lys Glu Glu Arg Ser Met Gln Leu Asp Asp 
        755                 760                 765             


Leu Lys Val Phe Ile Lys Glu Lys Phe Gly Asn Lys Arg Thr Asp Asp 
    770                 775                 780                 


Asn Thr Ile Arg Phe Leu Lys Lys Ala Ala Lys Arg Ile Arg Glu Asn 
785                 790                 795                 800 


Glu Ser Glu Ile Leu Val Arg Gln Met Asp Asp Cys Ala Leu Phe Leu 
                805                 810                 815     


Met Val Asn Asp Leu Leu Glu Gly Gly Lys Phe Asn Asp Glu Asp Ile 
            820                 825                 830         


Glu Asn Ile Gly Tyr Asn Lys His His Asn Leu Leu Asp His Glu Tyr 
        835                 840                 845             


Asp Met Cys Glu Thr Ile Tyr Gly Arg Lys Val Thr Ala Arg Leu Pro 
    850                 855                 860                 


Ile Lys Arg Tyr Gly Glu Phe Arg Arg Phe Met Lys Asp Arg Arg Leu 
865                 870                 875                 880 


Gln Asn Leu Val Lys Tyr Tyr Pro Gly Asp His Glu Thr Pro Ile Pro 
                885                 890                 895     


Ser Gly Ile Pro Glu Ser Gly Lys Ala Met Glu Lys Asn Lys Lys Tyr 
            900                 905                 910         


Thr Tyr Ser Asn Leu Cys Asp Glu Leu Glu Ile Tyr Asp Lys Glu Arg 
        915                 920                 925             


Asp Asn Val Leu Asn Leu Ile Tyr Glu Val Asp Lys Ile Leu Val Asp 
    930                 935                 940                 


His Phe Pro Asp Lys Ile Met Lys Glu Glu Asp Gly Tyr Tyr Glu His 
945                 950                 955                 960 


Tyr His Cys Leu Asp Phe Ala Lys Lys Glu Phe Gly Leu Glu Ser Asp 
                965                 970                 975     


Val Glu Leu Leu Ser Gln Asp Asn Phe Lys Asp Leu Arg Asn Ala Leu 
            980                 985                 990         


Tyr His Asn Gln Ile Pro Tyr Asn  Asp Trp Val Ala Asp  Lys Ile Ser 
        995                 1000                 1005             


Lys Asp  Thr Glu Glu Pro Met  Tyr Val Arg Arg Ile  Phe Ser Phe 
    1010                 1015                 1020             


Ile Arg  Thr Val Tyr Ser Arg  Leu Leu Asp Gln Ile  Lys Ile Lys 
    1025                 1030                 1035             


Ile Glu  Lys Asp Glu Tyr Lys  Cys Lys 
    1040                 1045         


<210>  1557
<211>  1129
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1557

Met Glu Thr Asn Gln Gln Thr His Glu Asn Arg Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Asn Asn His Ile Ala Thr Asp Phe Lys Gln Ala Thr 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ala Ala Phe Leu Cys Asn Lys Thr 
    50                  55                  60                  


Ile Lys Asn Leu Asn Trp Asn His Val His Thr Arg Ala Val Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ser Glu Ser Leu Pro Lys Asp Glu 
                85                  90                  95      


Arg Glu Asn Ser Asp Thr Glu Gly Lys Asp Phe Thr Ser Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Ser Glu Leu Gln Asp Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Asp Ser Arg Lys Leu Ile Val 
    130                 135                 140                 


Ser Pro Glu Leu Ala Asn Phe Leu Thr Val Asn Phe Gln Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Ala Arg Met Lys Asp Val Leu Thr Asp Thr Asp Tyr 
                165                 170                 175     


Ala Leu Val Glu Asn Leu Gln Met Val Ala Pro Asp Asn Lys Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ala Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Thr Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asn Leu Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Ser 
            260                 265                 270         


Val Ile Thr Asp Lys Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Asp Asp Glu Arg 
    290                 295                 300                 


Glu Thr Ile Leu Asp Glu Ile Asp Tyr Gln Asp Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg Tyr Ser Asp Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Asp Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Asn Tyr Thr Lys Gln Phe Ala Gly Glu 
        355                 360                 365             


Gln Ala Glu Arg Lys Val Leu Glu Asn Ala Asn Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asp Pro Glu Leu Ile Gln Gln Arg Ile Asp Lys Gln 
385                 390                 395                 400 


Gln His Thr Ala Gly Phe Asp Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Thr Lys Glu Asn Ile Ala Thr Leu Ile 
            420                 425                 430         


Ala Lys Ser Lys Ala Ser Ser Lys Val Glu His Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Gln Ala Glu Glu Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Ile Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Ser Gln Leu Pro Ala Asn Trp Asp Glu Phe Ser Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asp Ser Thr Leu Lys Tyr Leu 
        515                 520                 525             


Arg Gln Arg Lys Thr Thr Leu Asn Thr Ile Leu Ser Lys Ser Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Lys Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Thr Arg Leu Lys Ala Val Glu Lys His Lys Leu 
            580                 585                 590         


Asn Lys Ser Val Lys Ile Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Glu Glu Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Ala Asn Ala Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Phe Glu Asn Gly Gly His Pro Phe Leu Gln Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Gln Ala Tyr Leu Val 
        675                 680                 685             


Glu Lys Gly Asn Lys Met Val Pro Arg Leu Asn Pro Lys Thr Asn Lys 
    690                 695                 700                 


Thr Ser Lys Val Asp Glu Ser Trp Met Met Lys Gln Phe Tyr Val Lys 
705                 710                 715                 720 


Glu Trp Lys Glu Glu Ile Ala Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Ser Arg Ile Pro Phe Thr Ile Arg Gln Trp Asp Glu Lys 
            740                 745                 750         


Glu Lys Tyr Asp Leu Asn Val Trp Leu Gln His Val Thr Val Gly Lys 
        755                 760                 765             


Asn Lys Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe Asp 
    770                 775                 780                 


Glu Ala Leu Cys Asn Leu Leu Arg Glu Gln Leu Asp Thr Lys Ile Val 
785                 790                 795                 800 


Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Ile Trp Trp 
                805                 810                 815     


Lys Thr Arg Asn Asp Asp Thr Gln Gln Phe Tyr Gln Ser Glu Arg Glu 
            820                 825                 830         


Tyr Asp Ile Tyr Asn Glu Lys Val Arg Phe Lys Ile Asp Ser Ser Thr 
        835                 840                 845             


His Phe Ala Asp Tyr Tyr Lys Asn Ala Leu Ser Arg Ala Tyr Thr Arg 
    850                 855                 860                 


Leu Lys Ala Glu Arg Glu Thr Ala Arg Gln Thr Asn Lys Arg Leu Pro 
865                 870                 875                 880 


Pro Leu Glu Tyr Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile Ala 
                885                 890                 895     


Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met Ala 
            900                 905                 910         


Val Leu Met Leu Glu Gln Leu Met Asp Asn Ser Pro Asn Leu Arg Leu 
        915                 920                 925             


Ser Lys Ile Glu Thr Leu Leu Asn Asp Thr Thr Pro Ile Ser Glu Lys 
    930                 935                 940                 


Ile Ser Ala Lys Leu Ser Phe Asp Ala Ser Gly Glu Arg Ile Thr Asp 
945                 950                 955                 960 


Lys Ser Asn Pro Thr Ala Thr Lys Thr Leu Val Ala Glu Arg Lys Gln 
                965                 970                 975     


Lys Asn Tyr Thr Glu Leu Gln Lys Tyr Arg Tyr Asp Arg Arg Leu Pro 
            980                 985                 990         


Glu Leu Phe Glu Tyr Val Gln Ala  Asp Glu Ile Pro Leu  Glu Trp Leu 
        995                 1000                 1005             


Leu Asp  Glu Leu Ser Ala Tyr  Asn Ser Ala Lys Gln  Gln Val Phe 
    1010                 1015                 1020             


Asp Thr  Val Phe Ala Leu Glu  Lys Lys Ile Ile Gln  Thr Glu Pro 
    1025                 1030                 1035             


Asp Glu  Leu Lys Ser Leu Phe  Thr Gly Ala Asn Gly  Glu Leu Gln 
    1040                 1045                 1050             


Thr Gly  Asn Ile Gln His Lys  Pro Tyr Val Gln Trp  Leu Thr Asn 
    1055                 1060                 1065             


Lys Gly  Leu Ile Asn Lys Glu  Glu Lys Gln Phe Ile  Asn Met Val 
    1070                 1075                 1080             


Arg Lys  Cys Phe Ser His Asn  Gln Phe Pro Gln Arg  Thr Thr Met 
    1085                 1090                 1095             


Glu Leu  Leu Ile Pro Ala Trp  Asn Glu Lys Lys Leu  Ala Leu Gln 
    1100                 1105                 1110             


Ile Ala  Thr Val Tyr Asn Gln  Leu Ile Ala Asp Leu  Thr Asp Lys 
    1115                 1120                 1125             


Ile 
    


<210>  1558
<211>  1047
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1558

Met Glu Thr Glu Val Thr Ala Gln Asn Asn Ser Leu Thr Leu Thr Asn 
1               5                   10                  15      


Asn Pro Tyr Tyr Phe Ala His Tyr Ala Asn Met Ala Arg His Asn Ala 
            20                  25                  30          


Tyr Ile Val Leu Asn Glu Ile Asn Glu Lys Ile Tyr Asn Asn Lys Val 
        35                  40                  45              


Lys Ile Pro Glu Asp Gly Leu Ser Glu Cys Lys Leu Val Asn Ser Phe 
    50                  55                  60                  


Ser Lys Lys Asn Lys Lys Ala Asp Glu Tyr Ala Arg Ile Ile Lys Leu 
65                  70                  75                  80  


Leu Thr Glu His Tyr Pro Phe Ile Arg Phe Tyr Ala Asp Ser Ser Lys 
                85                  90                  95      


Glu Met Gly Asn Ile Pro Leu Lys Ala Tyr Leu Asp Ile Leu Asp Lys 
            100                 105                 110         


Ile Arg Asn Glu Asn Asn His Tyr Asn His Thr Ala Glu Arg Lys Glu 
        115                 120                 125             


Ile Ser Lys Ile Gln Glu Leu Phe Leu Phe Ala Lys Glu Lys Ala Lys 
    130                 135                 140                 


Gly Arg Met Ile Glu Phe Ser Pro Glu Asp Phe Asp His Leu Asn Asn 
145                 150                 155                 160 


Ser Lys Tyr Tyr Ala Met Thr Glu Asp Gly Ser Leu Thr Asn Thr Gly 
                165                 170                 175     


Ile Tyr Phe Phe Leu Cys Leu Phe Leu Glu Lys Lys His Ala Phe Gln 
            180                 185                 190         


Phe Leu Ser Arg Ile Lys Gly Phe Lys His Arg Glu Gln Lys Ser His 
        195                 200                 205             


Arg Ala Thr Leu Glu Thr Phe Thr Gln Leu Cys Cys Arg Leu Pro Tyr 
    210                 215                 220                 


Pro Lys Leu Glu Ser Ser Asp Val Ala Leu Asp Met Leu Asn Glu Ile 
225                 230                 235                 240 


Ala Arg Cys Pro Asn Ala Leu Tyr Gly Val Leu Glu Asn Lys Asp Lys 
                245                 250                 255     


Glu Thr Phe Lys Val Glu Phe Lys Asn Gly Ala Thr Asn Asn Glu Met 
            260                 265                 270         


Glu Val Pro Glu Pro Val Met Lys Arg His Asp Asp Arg Phe Pro Tyr 
        275                 280                 285             


Phe Ala Leu Arg Tyr Phe Asp Lys Ser Gln Ala Leu Asp Gly Ile Thr 
    290                 295                 300                 


Ser His Leu Gln Leu Gly Arg Arg Ile Val Ser Asp Pro His Gln Lys 
305                 310                 315                 320 


Lys Ile Gly Ala Glu Val Arg Thr His Glu Ile Leu Lys Asp Met Arg 
                325                 330                 335     


Thr Ala His Gln Leu Ala Tyr Phe Glu Thr Asp Ala Ala Lys Glu Phe 
            340                 345                 350         


Tyr Thr Asn Ile Pro Val Val Glu His Tyr Ala Pro Gln Tyr Arg Ile 
        355                 360                 365             


Val Gly Asn Arg Ile Gly Leu Phe Phe Asp Tyr Glu Cys Trp Gly Lys 
    370                 375                 380                 


Tyr Thr Val Pro Lys Glu Asn Val Lys Pro Asp Ala Ile Ile Ser Ile 
385                 390                 395                 400 


His Asp Leu Gly Ala Leu Tyr Phe Tyr Asn Arg Leu Tyr Lys Glu Gly 
                405                 410                 415     


Ser Val Lys Gln Ser Pro Lys Glu Leu Met Lys Ser Tyr Leu Glu Asn 
            420                 425                 430         


Met Asn Arg Leu Phe Asp Asp Val Lys Lys Gly Asn Ile Lys Pro Val 
        435                 440                 445             


Asn Asp Gly Glu Lys Leu Thr Pro Leu Phe Lys Ile Lys Asp Lys Glu 
    450                 455                 460                 


Asp Glu Tyr Glu Ile Arg Leu Glu Asn Leu Lys Glu Leu Ser Ala Leu 
465                 470                 475                 480 


Leu Gln Thr Glu Leu Asp Lys Arg Gly Tyr Gly Ile Glu Val Lys Asn 
                485                 490                 495     


Leu Pro Asp Val Cys Arg Glu Tyr Leu Leu Gly Tyr Lys Glu Ser Ser 
            500                 505                 510         


Ala Lys Asp Lys Ala Lys Arg Arg Phe Lys Arg Met Leu Arg Glu Thr 
        515                 520                 525             


Gln Phe Ala Leu Lys Lys Val Glu Arg Val Leu Ile Gln Glu Thr Ser 
    530                 535                 540                 


Leu Leu Ala Ser Gly Leu Lys Val Gly Glu Met Ala Gln Glu Leu Ala 
545                 550                 555                 560 


Arg Asp Ile Val Phe Leu Ile Lys Pro Lys Ile Val Lys Lys Ile Ile 
                565                 570                 575     


Lys Ser Gly Thr Asp Ala Gly Lys Glu Val Glu Cys Lys Gln Lys Ile 
            580                 585                 590         


Asn Asn Met Glu Phe Asp Val Leu Gln Lys Met Leu Ala Phe Tyr Pro 
        595                 600                 605             


Val Tyr Lys Glu Glu Ile Glu His Phe Leu Trp Thr Met Val Asn Lys 
    610                 615                 620                 


Arg Asp Pro Asn Ala Phe Ser His Pro Phe Leu Phe Arg Ala Leu Leu 
625                 630                 635                 640 


Lys Ile Lys Thr Cys Arg Asn Leu Asn Asp Phe Tyr Lys Glu Tyr Tyr 
                645                 650                 655     


Leu His Lys Gln Arg Trp Ile Glu Gly Val Ser Lys Ser Ile Thr Pro 
            660                 665                 670         


Glu Val Leu Arg Asp Asn Glu Tyr Phe Leu Lys Leu Glu Asn Gly Asn 
        675                 680                 685             


Ala Phe Pro His Asn Tyr Asn Gly Glu Ala Ile Phe Ile Pro Ser Gly 
    690                 695                 700                 


Phe Phe Asn Lys Glu Ile Thr Arg Ala Met Val Gln Ile Gly Tyr Lys 
705                 710                 715                 720 


Ile Glu Asn Pro Glu Lys Gly Ala Asn Ala Ala Tyr Trp Ile Lys Gln 
                725                 730                 735     


Tyr Phe Glu Gly Lys Ser Gln Pro Phe Tyr Asn Leu Pro Arg Tyr Tyr 
            740                 745                 750         


Asn Glu Ser Leu Gly Gly Lys Glu Pro Val Tyr Ile Glu Arg Asp Lys 
        755                 760                 765             


Leu Lys Lys Gln Ile Leu Glu Gly Asp Phe Asn Arg Leu Thr Glu Asp 
    770                 775                 780                 


Glu Gln Lys Arg Arg Lys Val Leu Ala Lys Arg Ile Arg Glu Asn Glu 
785                 790                 795                 800 


Ser Glu Ile Leu Thr Asn Gln Thr Asn Asp Arg Val Met Tyr Leu Met 
                805                 810                 815     


Ala Met Glu Leu Ile Asp Ser Glu Asn Pro Leu Lys Lys Asn Glu Ile 
            820                 825                 830         


Val Ser Val Gly Tyr Asn Ile Lys Glu Gly Thr Asn Leu Leu Asp Asn 
        835                 840                 845             


Asn Lys Val Ser Trp Asn Ile Gln Gly Arg Arg Val Val Ala Glu Leu 
    850                 855                 860                 


Pro Ile Lys Arg Tyr Gly Glu Tyr Arg Arg Phe Leu Lys Asp Arg Arg 
865                 870                 875                 880 


Leu Glu Asn Leu Leu Lys Tyr Tyr Pro Glu Gly Lys Glu Leu Gln Leu 
                885                 890                 895     


Gly Thr Leu Lys Ser Gly Glu Val Glu Glu Lys Gly Lys Lys Tyr Thr 
            900                 905                 910         


Asn Ser Asn Leu Val Asp Glu Leu Glu Leu Phe Asp Leu Lys Arg Asn 
        915                 920                 925             


Glu Leu Met Glu Gln Val Tyr Leu Phe Glu Lys Ile Leu Cys Thr Asn 
    930                 935                 940                 


Tyr Ala Asp Lys Ile Lys Ala Val Leu Pro Asp Lys Glu Arg Asn Lys 
945                 950                 955                 960 


Pro Tyr Ile Glu His Tyr His Cys Leu Met Tyr Ala Lys Asn Glu Met 
                965                 970                 975     


Lys Leu Phe Lys Glu Val Gly Glu Leu Glu His Glu His Phe Asn Glu 
            980                 985                 990         


Leu Arg Asn Lys Ile Ser His Asn  Gln Met Pro Tyr Thr  Asp Trp Leu 
        995                 1000                 1005             


Met Glu  Arg Val Ile Ala Asn  Lys Glu Glu Pro Met  Ile Thr Asn 
    1010                 1015                 1020             


Arg Ile  Val Asp Leu Ile Leu  Ser Ile Tyr Lys Glu  Leu Asn Ser 
    1025                 1030                 1035             


Gln Leu  Val Ile Ile Thr Asn  Ser Lys 
    1040                 1045         


<210>  1559
<211>  1073
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1559

Met Cys Asn Asn Ser Gln Gly Asn His Ile Thr Gln Asn Asn Lys Ser 
1               5                   10                  15      


Phe Leu Gly Ile Phe Leu Asn Gln Ala Arg Leu Asn Ala Tyr Ile Thr 
            20                  25                  30          


Leu Cys Gln Ile Ser Asp Gln Leu Gly Val Arg Thr Val Asp Glu Asp 
        35                  40                  45              


Ser Leu Ser Glu Met Pro Ile Leu Lys Phe Leu Glu Glu Pro Ala Glu 
    50                  55                  60                  


Asn Thr Val Lys Ser Arg Arg Thr Thr Glu Leu Ile Glu Lys His Phe 
65                  70                  75                  80  


Pro Met Leu Lys Ile Ile Tyr Asp Trp Gln Lys Glu Lys Gly Lys Glu 
                85                  90                  95      


Asp Asp Phe Lys Asp His Ser Lys Lys Tyr Lys Lys Ile Leu Thr Cys 
            100                 105                 110         


Leu Leu Lys Ala Ile Asn Cys Lys Arg Asn Glu Tyr Cys His Ala Tyr 
        115                 120                 125             


Ser Asn Asp Thr Leu Ala Asp Lys Asp Val Asp Val Lys Glu Leu Cys 
    130                 135                 140                 


Arg Tyr Leu Asp Asn Cys Phe Asp Thr Ser Val Asn Arg Val Lys Asp 
145                 150                 155                 160 


Thr Arg Ser Leu Asp Glu Glu Asp Val Phe His Leu Arg Arg Lys Thr 
                165                 170                 175     


Ala Glu Gly Lys Gly Lys Asn Lys Arg Val Ile Asp Asn Pro Glu Phe 
            180                 185                 190         


Tyr Tyr His Phe Met Asp Glu Gln Gly Arg Leu Gly Glu Lys Gly Leu 
        195                 200                 205             


Ser Tyr Leu Ala Thr Leu Phe Leu Glu Lys Lys Asp Ala Tyr Glu Leu 
    210                 215                 220                 


Leu Lys Gln Gln Thr Gly Phe Lys Arg Asp Asp Lys Pro Lys Tyr Lys 
225                 230                 235                 240 


Ala Thr Leu Glu Cys Phe Cys Cys Tyr Arg Ile Lys Leu Pro Lys Pro 
                245                 250                 255     


Val Met Thr Ser Asp Val Asp Arg Asn Gly Leu Ala Leu Asp Met Leu 
            260                 265                 270         


Asn Glu Leu Lys Lys Cys Pro Lys Glu Leu Phe Asp Leu Leu Ser Lys 
        275                 280                 285             


Glu Arg Gln Gln Glu Phe Arg Val Ala Thr Asp Ala Ser Asp Asp Asn 
    290                 295                 300                 


Asp Asp Ala Asp Glu Ile Leu Met Met Arg His Ser Asp Arg Phe Pro 
305                 310                 315                 320 


Tyr Leu Ala Val Arg Tyr Cys Asp Glu Asn Glu Val Phe Arg Asn Leu 
                325                 330                 335     


Arg Phe Gln Ile Asp Leu Gly Arg Tyr Tyr Phe Lys Phe Tyr Glu Lys 
            340                 345                 350         


Gln Thr Ile Asp Gly Asn Thr Tyr Pro Arg Ala Leu Asp Lys Arg Leu 
        355                 360                 365             


Lys Thr Phe Gly Arg Ile Lys Glu Val Lys Asn Lys Val Gln Gln Gln 
    370                 375                 380                 


Trp Gly Glu Ile Ile Lys Ser Pro Asp Asp Val Asn Asp Glu Gln Asn 
385                 390                 395                 400 


Glu Pro Tyr Lys Ala Asn Thr Thr Pro His Tyr His Leu Val Asp Asn 
                405                 410                 415     


Gln Ile Ala Phe Ile Ile Ala Gly Asp Cys Ala Leu Pro Asp Ile Asn 
            420                 425                 430         


Gln Pro Asp Gly Lys Ile Lys Leu Gln Lys Pro Asp Ala Trp Leu Ser 
        435                 440                 445             


Ile Tyr Glu Leu Pro Gly Met Ile Phe His Gly Leu Lys Cys Arg Phe 
    450                 455                 460                 


Gln Glu Thr Glu Arg Leu Ile Glu Ile Tyr Ile Lys Lys Gln Arg Lys 
465                 470                 475                 480 


Ile Cys Glu Lys Ile Cys Lys Thr Gly Val Ile Pro Glu Gly Ala Gly 
                485                 490                 495     


Glu Phe Leu Pro Glu Ala Leu Lys Asp Ile Glu Ala Asn Ala Val Lys 
            500                 505                 510         


Gln Ser Asn Tyr Ala Lys Lys Lys Leu Gln Arg Met Leu Asp Glu Thr 
        515                 520                 525             


Gln Arg Arg Ile Arg Ala Leu Arg Thr Thr Gln Gln Arg Ala Ala Asp 
    530                 535                 540                 


Lys Ser Asn Lys Pro Gly Lys Lys Lys Tyr Phe Asp Ile Arg Ala Gly 
545                 550                 555                 560 


Lys Leu Ala Asp Phe Leu Ala Arg Asp Ile Ile Ala Leu Gln Lys Phe 
                565                 570                 575     


Asp Pro Ala Lys Glu Gly Arg Asp Lys Leu Thr Ser Ile Asn Tyr Gln 
            580                 585                 590         


Val Leu Gln Ala Thr Leu Ala Tyr Tyr Gly Ala Lys Lys Asp Thr Ile 
        595                 600                 605             


Thr Asp Met Phe Lys Arg Ile Gly Leu Leu Asp Gly Asp Asn Pro His 
    610                 615                 620                 


Pro Phe Leu Lys Glu Ile Asp Pro Ala Lys Tyr Asn Ser Ile Val Arg 
625                 630                 635                 640 


Phe Tyr Glu Ala Tyr Leu Met Ala Lys Arg Ser Tyr Leu Glu His Cys 
                645                 650                 655     


Lys Glu Lys Gly Lys Phe Asp Glu Gln Phe Leu Arg Pro Ser Arg Gln 
            660                 665                 670         


Arg Tyr Ala Arg Asp Lys Arg Glu Leu Lys Thr Ile Ala Arg Gln Leu 
        675                 680                 685             


Leu Asp Asn Pro Val Asn Ile Pro Lys Asn Phe Phe Arg Asp Lys Ile 
    690                 695                 700                 


Lys Gln Val Val Cys Asn Glu Asp Pro Ser Leu Lys Asp Arg Gln Met 
705                 710                 715                 720 


Asn Thr Ala Tyr Met Ile Gln Ala Trp Phe Glu Lys Thr Lys Gly Thr 
                725                 730                 735     


Gln Gln Pro Phe Tyr Gly Tyr Glu Arg Thr Tyr Pro Val Val Leu Lys 
            740                 745                 750         


Ala Lys Gln Tyr Gly Lys Lys Ala Lys Asn Lys Pro Ile Glu Ala Phe 
        755                 760                 765             


Leu Glu Lys Ile Thr Pro Glu Ile Ser Tyr Lys Glu Leu Lys Glu Leu 
    770                 775                 780                 


Ile Glu Thr Glu Ile Pro Asp Ser Gly Glu Tyr Glu Pro Glu Ser Leu 
785                 790                 795                 800 


Lys Lys Asn Leu Leu Asp Ala Cys Arg Asp Phe Lys Asn Asn Glu Arg 
                805                 810                 815     


Leu Leu Arg Arg Phe Lys Val Gln Asp Ile Val Thr Phe Met Thr Val 
            820                 825                 830         


Glu Asn Thr Leu Lys Asp Gln Leu Ser Phe Glu Gly Asn Val Val Lys 
        835                 840                 845             


Leu Glu Asp Ile Thr Pro Ser Glu Asp Ser Pro Phe Asn Lys Pro Val 
    850                 855                 860                 


Leu Cys Ser Thr Asp Ile Ser Val Ser Phe Asn Ile Arg Lys Lys Tyr 
865                 870                 875                 880 


Glu Ser Ala Tyr Val Glu Phe Ile Thr Glu Arg Phe Thr Ser Ser Tyr 
                885                 890                 895     


Glu Lys Gln Gly Asn Arg Val Ile Leu Thr Tyr Arg Ile Asn Ser Glu 
            900                 905                 910         


Asn Arg Lys Leu Lys Asp Leu Gly Lys Tyr Arg Arg Tyr Phe Tyr Asp 
        915                 920                 925             


Arg Arg Leu Pro Gly Leu Leu Leu Trp Lys Tyr Pro Pro Asn Ala Lys 
    930                 935                 940                 


Gly Gly Pro Glu Ile Lys Tyr Ala Asp Leu Glu Glu Glu Ile Lys Ala 
945                 950                 955                 960 


Tyr Glu Lys Tyr Arg Lys Gln Ile Ala Gln Trp Leu Tyr Val Leu Glu 
                965                 970                 975     


Lys Ser Thr Val Asp His Phe Lys Leu Glu Ile Glu Pro Lys Glu Asn 
            980                 985                 990         


Tyr Ile Pro Phe Asn Ala Val Ile  Asp Ser Val Lys Cys  Gly Leu Pro 
        995                 1000                 1005             


Glu Ser  Gly Asp Glu Cys Asp  Thr Leu Leu Asn Ile  Arg Asn Ala 
    1010                 1015                 1020             


Val Asn  His Asn Gln Phe Pro  Val Trp Arg Glu Ala  Ile Glu Asn 
    1025                 1030                 1035             


Ala Pro  Gly Gln Thr Ile Ala  Glu Lys Met Leu Tyr  Ile Thr Glu 
    1040                 1045                 1050             


Thr Cys  Val Lys His Ile Thr  Asp His Ile Thr Glu  Ser Asp Lys 
    1055                 1060                 1065             


Asp Val  Val Tyr Ala 
    1070             


<210>  1560
<211>  1075
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1560

Met Tyr Asp Lys Ser Gln Glu Asn His Val Glu Gln Lys Asp Lys Ser 
1               5                   10                  15      


Leu Phe Gly Val Tyr Leu Asn Gln Ala Arg Leu Asn Ala Tyr Ile Thr 
            20                  25                  30          


Leu Cys His Ile Ser Glu Leu Leu Gly Val Lys Thr Val Asp Glu Asp 
        35                  40                  45              


Ser Ile Ser Ile Met Pro Val Leu Glu Phe Leu Glu Asn Glu Lys Asp 
    50                  55                  60                  


Ala Ile Lys Ser Gln Ser Val Phe Arg Leu Ile Glu Lys His Phe Pro 
65                  70                  75                  80  


Met Leu Lys Ile Ile Tyr Asp Trp Gln Lys Glu Lys Gly Lys Val Asp 
                85                  90                  95      


Asp Leu Lys Glu His Ser Glu Lys Tyr Lys Lys Ile Leu Thr Cys Met 
            100                 105                 110         


Leu Lys Ala Leu Asn Asp Lys Arg Asn Glu Tyr Cys His Ala Lys Thr 
        115                 120                 125             


Glu Glu Val Lys Lys Lys Tyr Asp Val Asn Glu Leu Ile Arg Tyr Leu 
    130                 135                 140                 


Asp Gly Cys Phe Asp Ala Ser Val Arg Arg Ile Lys Glu Asn His Arg 
145                 150                 155                 160 


Leu Ala Glu Asn Glu Val Thr His Leu Arg Arg Phe Thr Glu Gly Lys 
                165                 170                 175     


Asp Glu Asn Gly Arg Pro Leu Tyr Asn Pro Asp Phe His Tyr Gln Phe 
            180                 185                 190         


Lys Asp Glu Asn Gly Glu Leu Asn Glu Lys Gly Leu Tyr Phe Leu Thr 
        195                 200                 205             


Ala Ile Phe Leu Glu Lys Arg Asp Ala His Glu Phe Leu Lys Lys Gln 
    210                 215                 220                 


Lys Tyr Phe Met Asn Asp Ser Lys Pro Lys Tyr Arg Ala Thr Leu Glu 
225                 230                 235                 240 


Ser Phe Tyr Cys Phe Arg Ile Lys Leu Pro Lys Pro Val Met Glu Ser 
                245                 250                 255     


Asn Val Asp Lys Asn Gly Leu Ala Leu Asp Met Leu Asn Glu Leu Lys 
            260                 265                 270         


Lys Cys Pro Lys Glu Leu Phe Glu Leu Ile Ser Lys Glu Gln Arg Lys 
        275                 280                 285             


Asp Phe Arg Val Met Asp Ser Glu Asp Ser Asp Glu Asp Ser Asn Glu 
    290                 295                 300                 


Ala Leu Met Arg Arg Tyr Ser Asp Arg Phe Pro Tyr Phe Ala Leu Arg 
305                 310                 315                 320 


Tyr Cys Asp Glu Asn Gln Val Phe Asp Asn Leu Arg Phe Gln Ile Asp 
                325                 330                 335     


Leu Gly Arg Tyr Tyr Phe Lys Phe Tyr Glu Lys Glu Thr Ile Asp Gly 
            340                 345                 350         


Asn Lys Tyr Pro Arg Ala Leu Asp Lys Arg Leu Lys Thr Phe Gly Arg 
        355                 360                 365             


Ile Arg Glu Val Lys Glu Lys Val Glu Lys Glu Trp Asn Asp Ile Ile 
    370                 375                 380                 


Lys Ala Pro Asp Glu Ile Val Glu Gly Gln Glu Glu Pro Tyr Lys Gln 
385                 390                 395                 400 


Lys Ser Ile Pro His Tyr Asn Ile Val Asp Asn Gln Ile Gly Phe Val 
                405                 410                 415     


Leu Leu Glu Asn Gly Lys Glu Lys Gln Leu Pro Asp Ile Lys Gln Ala 
            420                 425                 430         


Asp Gly Lys Ile Glu Leu Gln Lys Pro Asp Ala Trp Leu Ser Ile Tyr 
        435                 440                 445             


Glu Leu Pro Gly Val Ile Phe His Gly Leu Asn Tyr Glu Leu Asn Asn 
    450                 455                 460                 


Lys Phe Lys Lys Thr Glu Ser Leu Ile Glu Gln Tyr Ile Lys Lys Gln 
465                 470                 475                 480 


Arg Glu Ile Cys Glu Glu Val Tyr Lys Thr Gly Lys Ile Pro Gln Lys 
                485                 490                 495     


Ala Gly Glu Phe Leu Pro Glu Ala Leu Lys Asp Ile Glu Lys Ser Asn 
            500                 505                 510         


Thr Glu Asn Tyr Ser Arg Lys Lys Leu Asp Arg Met Leu Lys Asp Thr 
        515                 520                 525             


Asp Gln Arg Ile Lys Ala Ile Lys Lys Thr Lys Glu Arg Ala Ala Asp 
    530                 535                 540                 


Lys Ser Asn Lys Pro Gly Lys Lys Met Phe Ile Asp Ile Lys Ala Gly 
545                 550                 555                 560 


Lys Leu Ala Asp Phe Leu Ala Arg Asp Ile Met Ala Met Gln Lys Phe 
                565                 570                 575     


Asp Pro Asp Lys Lys Gly Lys Asp Lys Leu Thr Ser Ile Asn Phe Gln 
            580                 585                 590         


Val Leu Gln Ala Thr Leu Ala Tyr Tyr Gly Ala Lys Lys Asp Thr Ile 
        595                 600                 605             


Gly Asp Met Phe Lys Arg Ile Gly Leu Ile Asp Gly Asp Asn Pro His 
    610                 615                 620                 


Pro Phe Leu Asn Gln Ile Asn Pro Ala Lys Tyr Asn Ser Ile Ala Asp 
625                 630                 635                 640 


Phe Tyr Ile Thr Tyr Leu Asp Ser Lys Glu Gln Tyr Leu Lys Asn Cys 
                645                 650                 655     


Lys Lys Asp Gly Asp Phe Glu Asn Tyr Gln Phe Leu Arg Pro Ser Arg 
            660                 665                 670         


Gln His Tyr Ala Gly Lys Arg Glu Leu Lys Thr Ile Ala Lys Gln Leu 
        675                 680                 685             


Leu Asp Asn Pro Val Asn Ile Pro Lys Gly Phe Phe Glu Lys Glu Ile 
    690                 695                 700                 


Glu Lys Phe Ile Leu Ala Gln Asn Pro Ser Ala Lys Lys Glu Lys Met 
705                 710                 715                 720 


Asn Thr Ala Tyr Met Ile Gln Ala Trp Phe Glu Ile Asn Cys Gly Gly 
                725                 730                 735     


Gln Gln Pro Phe Tyr Ser Tyr Gly Arg Thr Tyr Pro Val Val Leu Lys 
            740                 745                 750         


Ala Ala Glu Tyr Arg Lys Lys Arg Gln Asn Thr Lys Ile Asp Lys Thr 
        755                 760                 765             


Leu Arg Leu Ile Thr Pro Lys Leu Asn Tyr Met Asp Ile Lys Lys Ile 
    770                 775                 780                 


Val Thr Glu Met Pro Glu Gly Lys Tyr Glu Pro Glu Asn Leu Lys Lys 
785                 790                 795                 800 


Asn Leu Tyr Glu Gly Tyr Lys Asp Phe Glu Lys Asn Glu Arg Ile Leu 
                805                 810                 815     


Arg Arg Tyr Lys Val Gln Asp Met Val Thr Phe Met Thr Val Glu Lys 
            820                 825                 830         


Arg Leu Lys Asp Gln Leu Ser Ile Lys Gly Asn Pro Leu Arg Leu Glu 
        835                 840                 845             


Ala Val Thr Pro Lys Gly Lys Ser Leu Phe Lys Lys Pro Ile Pro Cys 
    850                 855                 860                 


Asn Thr Asp Val Ser Val Ser Phe Asn Thr Asn Val Lys His Glu Thr 
865                 870                 875                 880 


Gly Tyr Val Asn Tyr Ile Arg Glu Lys Tyr Asp Gly Ser Tyr Ile Cys 
                885                 890                 895     


Pro Gly Lys Lys Ile Ile Leu Lys Tyr Arg Val Ile Ser Glu Asn Ala 
            900                 905                 910         


Lys Leu Lys Asp Ile Gly Lys Tyr Arg Arg Tyr Phe Tyr Asp Arg Arg 
        915                 920                 925             


Leu Pro Gly Leu Leu Ile Trp Lys Tyr Arg Pro Asn Thr Ser Asp Gly 
    930                 935                 940                 


Thr Glu Ile Lys Tyr Ala Asp Ile Glu Glu Glu Ile Lys Ala Tyr Glu 
945                 950                 955                 960 


Lys His Arg Lys Glu Ile Ala Gln Gln Met Tyr Met Leu Glu Lys Gly 
                965                 970                 975     


Val Ile Asp Gln Phe Ser Leu Glu Ile Glu Pro Gly Glu Asn Tyr Ile 
            980                 985                 990         


Pro Phe Glu Lys Ile Ile Glu Thr  Ile Lys Ala Asn Leu  Val Gly Phe 
        995                 1000                 1005             


Asp Glu  Lys Cys Glu Thr Val  Arg Lys Ile Arg Asn  Ala Val Tyr 
    1010                 1015                 1020             


His Asn  Gln Phe Pro Val Arg  Glu Glu Ala Ile His  Ser Ala Gln 
    1025                 1030                 1035             


Gly Glu  Glu Ile Ala Glu Lys  Met Arg Ser Val Thr  Glu Ser Tyr 
    1040                 1045                 1050             


Val Glu  Gln Ile Met Thr Asn  Ile Glu Ser Asn Val  Lys Gly Phe 
    1055                 1060                 1065             


Glu Asn  Val Ala Ser Ser Cys  
    1070                 1075 


<210>  1561
<211>  1160
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1561

Met Lys Thr Leu Gly Ala Leu Ser Ser His Asn Tyr Asn Asn Lys Lys 
1               5                   10                  15      


Tyr Tyr Phe Ser Gly Leu Leu Asn Thr Ala Gln Tyr Asn Phe Asn Leu 
            20                  25                  30          


Ala Leu Gln Glu Val Asn Asp Arg Leu Gly Lys Lys Gly Lys Asn Pro 
        35                  40                  45              


Gly Lys Thr Met Ile Lys Asn Ile Phe Asp Gln Lys Asp Ser Phe Ser 
    50                  55                  60                  


Thr Gln Glu Arg Ala Met Tyr Tyr Leu Glu Glu Phe Phe Pro Trp Ile 
65                  70                  75                  80  


Phe Leu Val Met Lys Gln Ser Gly Ile Asn Ile Pro Thr Glu Glu Gln 
                85                  90                  95      


Glu Thr Lys Leu His Lys Glu Glu Ile Gln Leu Ile Gln Glu His Leu 
            100                 105                 110         


Ile Ser Leu Tyr Glu Leu Leu Asp Asp Leu Arg Asn Glu Gln Thr His 
        115                 120                 125             


Tyr Met His Asp Pro Val Ile Ile Pro Glu Glu Val Ser Lys Met Leu 
    130                 135                 140                 


Asp Ala Leu Leu Leu Gln Ile Leu Lys Asn Thr Arg Lys Lys Cys Lys 
145                 150                 155                 160 


Asp Asp Glu Tyr Arg Thr Phe Ile Val Lys Lys Tyr Gln Glu Glu Phe 
                165                 170                 175     


Gln Lys Glu Ile Lys Val Gln Val Lys Asp Arg Phe Gly Lys Glu Lys 
            180                 185                 190         


Glu Lys Ile Val Thr Gly Glu Val Lys Glu Asn Tyr Val Ile Asn Arg 
        195                 200                 205             


Cys Phe Arg Lys Trp Ile Gln Lys Glu Gly Glu Glu Glu Thr Leu Arg 
    210                 215                 220                 


Tyr Ser Thr Val Gln Glu Glu Gln Gly Lys Tyr Val Trp Ser Ser Ser 
225                 230                 235                 240 


Gly Phe Val Phe Phe Leu Ser Leu Phe Leu Arg Arg Lys Glu Leu Glu 
                245                 250                 255     


Asp Val Met Asn His Val Pro Tyr Phe Lys Asp Ser Arg Lys Leu Leu 
            260                 265                 270         


Phe Tyr Leu Thr Arg Lys Thr Phe Ser Ser Tyr Cys Phe Arg Asp Leu 
        275                 280                 285             


Arg Lys Ser Leu Arg Ser Asp Tyr Ser Asn Asp Ser Leu Leu Met Gln 
    290                 295                 300                 


Met Ile Glu Glu Leu Tyr Lys Cys Pro Gly Glu Leu Tyr Glu Val Leu 
305                 310                 315                 320 


Leu Lys Glu Gln Lys Gln Glu Phe Ile Glu Asp Ile Asn Glu Tyr Tyr 
                325                 330                 335     


Lys Asp Asn Pro Glu Phe Glu Gly Ser Ala Asn Glu Ala Gln Val Ile 
            340                 345                 350         


His Pro Val Ile Arg Lys Arg Tyr Gln Asp Lys Phe Pro Tyr Phe Ala 
        355                 360                 365             


Leu Arg Phe Ile Asp Glu Tyr Phe Asn Phe Pro Thr Leu Arg Phe Gln 
    370                 375                 380                 


Leu Val Leu Gly Glu Tyr Val Thr Asp Arg Arg Thr Lys Glu Leu Gln 
385                 390                 395                 400 


Gly Thr Ala Leu Phe Thr Asp Arg Val Ile Ser Gln Arg Ile Ser Tyr 
                405                 410                 415     


Val Gly Lys Leu Ser Glu Ala Glu Met Asn Lys Lys Arg Glu Gly Tyr 
            420                 425                 430         


Thr Glu Thr Gly Trp Lys Glu Tyr Pro Asn Pro Tyr Tyr Lys Ile Glu 
        435                 440                 445             


Asn Asn Arg Ile Pro Leu Tyr Ile Glu Phe Ser Lys Asn Glu Glu Leu 
    450                 455                 460                 


Ile Phe Lys Glu Lys Lys Phe Lys Tyr Asn Thr Leu Ala Lys Trp Glu 
465                 470                 475                 480 


Asn Arg Glu Ile Asp Lys Arg Thr Gly Glu Phe Asn Gln Val Asn Lys 
                485                 490                 495     


Gln Arg Arg Ile Thr Gln Leu Glu Glu Phe Lys Ile Asp Asn Pro Lys 
            500                 505                 510         


Lys Met Lys Thr Pro Asn Val Phe Leu Ser Ile Tyr Glu Leu Pro Ala 
        515                 520                 525             


Leu Leu His Ala Leu Leu Ile Glu Lys Lys Thr Glu Ala Glu Ile Glu 
    530                 535                 540                 


Asp Ile Ile Lys Ala Lys Ile Lys Lys Gln Leu Thr Glu Ile Ala Glu 
545                 550                 555                 560 


Gly Arg Arg Asn Leu Ser Gly Leu Pro Lys Gly Ile Lys Lys Met Arg 
                565                 570                 575     


Asn Cys Asn Ser Asp Phe Glu Lys Lys Lys Leu Ile Ser Asp Ile Asp 
            580                 585                 590         


Asn Glu Ile Lys Lys Gly Glu Lys Ile Leu Glu Glu Val Gln Gln Trp 
        595                 600                 605             


Leu Asn Pro Val Ile Asn Lys Lys Gly Thr Gly Lys Gln Glu Asn Asn 
    610                 615                 620                 


Lys Pro Phe Phe Ser Asn Thr Tyr Arg Gly Lys Tyr Ala Thr Trp Leu 
625                 630                 635                 640 


Ala Tyr Asp Ile Lys Arg Phe Thr Gly Lys Asp His Ile Gln Asn Trp 
                645                 650                 655     


Lys Gly Tyr Gln Phe Ser Glu Leu Gln Thr Leu Leu Ser Leu Tyr Thr 
            660                 665                 670         


Leu Arg Lys Glu Glu Leu Lys Asn Phe Leu Glu Lys Asp Leu Gln Leu 
        675                 680                 685             


Thr Ser His Pro Phe Leu Lys Glu Ala Leu Lys Ala Val Asn Leu Glu 
    690                 695                 700                 


Asp Phe Met Gly Ala Tyr Leu Arg Gly Arg Gln Phe Phe Leu Glu Lys 
705                 710                 715                 720 


Ala Lys Lys Gln Ile Gly Ile Lys Gly Val Lys Lys Ser Ile Phe Gln 
                725                 730                 735     


Tyr Phe Glu Glu Arg Lys Tyr Lys Ile Tyr Ser Ser Asn Leu Asp Tyr 
            740                 745                 750         


Trp Glu Glu Leu Trp Lys His Pro Val Asn Leu Asp Arg Gly Leu Phe 
        755                 760                 765             


Asp Glu Arg Gly Thr Val Tyr Asn Lys Asn Lys Glu Leu Asn Asp Leu 
    770                 775                 780                 


Gln Asn Arg Ala Ala Trp Phe Ser Phe Ala Glu Thr Asn Pro Lys Gln 
785                 790                 795                 800 


Gln Phe Tyr His Phe Pro Arg Ile Tyr Ser Asp Glu Asp Ile Thr Lys 
                805                 810                 815     


Pro Val Thr Asp Arg Tyr Gly Lys Thr Lys Glu Lys Leu Ile Leu Phe 
            820                 825                 830         


Lys Leu Ser Pro Gln Lys Gly Phe Met Glu Gln Ile Pro Ser Asp Leu 
        835                 840                 845             


Lys Lys Lys Tyr Gln Glu Asp Lys Gly Lys Val Glu His Pro Glu Val 
    850                 855                 860                 


Gln Lys Glu Lys Lys Tyr Glu Glu Lys Lys His Pro Gly Ile Asn Ala 
865                 870                 875                 880 


Phe Ile Lys Asn Ala Tyr Lys Asn Glu Gln Lys Ile Arg Arg Ile Ser 
                885                 890                 895     


Arg Asn Asp Ile Phe Leu Tyr Glu Met Val Lys Tyr Met Leu Asn Lys 
            900                 905                 910         


Ile Ser Pro Ala Thr Glu Phe Ser Ser Leu Asp Lys Val Trp Leu Thr 
        915                 920                 925             


Arg Ile Glu Arg Glu Lys Gln Ala Thr Glu Ala Arg Glu Gln Ser Phe 
    930                 935                 940                 


Lys Glu Lys Gly Asp Thr Ser Glu Asn Lys Ile Arg Gln Asp Tyr Leu 
945                 950                 955                 960 


Leu Ser Phe Pro Ile Thr Leu Thr Leu Phe Asn Asp Ile Ile Lys Glu 
                965                 970                 975     


Lys Val Lys Ile Lys Asp Ile Gly Arg Phe Arg Lys Leu Glu Lys Asp 
            980                 985                 990         


Glu Arg Val Gln Thr Met Ile Ser  Tyr Tyr Thr Ser Gly  Leu Trp Lys 
        995                 1000                 1005             


Asn Asp  Gln Pro Ser Leu Thr  Ile Lys Glu Leu Glu  Ala Glu Leu 
    1010                 1015                 1020             


Glu Ser  Tyr His Lys Ile Arg  Leu Gln Glu Ile Phe  Lys Glu Val 
    1025                 1030                 1035             


His Lys  Leu Glu Lys Glu Ile  Tyr Glu Phe Thr Pro  Glu Glu Asp 
    1040                 1045                 1050             


Lys Ser  Lys Leu Leu Ala Arg  Glu Ser Phe Pro Lys  Phe Lys Tyr 
    1055                 1060                 1065             


Tyr Ile  Ser Phe Tyr Phe Ile  Pro Lys Glu Asp Gln  Glu Val Phe 
    1070                 1075                 1080             


Asn Glu  Ile Gln Phe Asp Lys  Tyr Lys Asn Leu Glu  Gln Ile Pro 
    1085                 1090                 1095             


Gly Arg  Lys Pro Glu Tyr Asp  Pro Tyr Tyr Leu Leu  Ile Phe Ile 
    1100                 1105                 1110             


Arg Asn  Lys Phe Ala His Asn  Gln Leu Pro Ala Glu  Pro Ile Tyr 
    1115                 1120                 1125             


Lys Thr  Ala Leu Thr Phe Leu  Pro Asn Asn Phe Asn  Thr Leu Ala 
    1130                 1135                 1140             


Glu Tyr  Tyr His Lys Leu Phe  Ile Leu Leu Asn Asn  Lys Asn Tyr 
    1145                 1150                 1155             


Asn Asn  
    1160 


<210>  1562
<211>  1118
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1562

Met Glu Asp Asp Lys Lys Thr Thr Glu Ser Thr Asn Met Leu Asp Asn 
1               5                   10                  15      


Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val Tyr 
            20                  25                  30          


Ile Thr Ile Asn His Ile Asn Lys Leu Leu Glu Ile Arg Glu Ile Asp 
        35                  40                  45              


Asn Asp Glu Lys Val Leu Asp Ile Lys Ala Leu Trp Gln Lys Gly Asn 
    50                  55                  60                  


Lys Asp Leu Asn Gln Lys Ala Arg Leu Arg Glu Leu Met Thr Lys His 
65                  70                  75                  80  


Phe Pro Phe Leu Glu Thr Ala Ile Tyr Thr Lys Asn Lys Glu Asp Lys 
                85                  90                  95      


Lys Glu Val Lys Gln Glu Lys Gln Ala Glu Ala Gln Ser Leu Glu Ser 
            100                 105                 110         


Leu Lys Asp Cys Leu Phe Leu Phe Leu Glu Lys Leu Gln Glu Ala Arg 
        115                 120                 125             


Asn Tyr Tyr Ser His Tyr Lys Tyr Ser Glu Ser Thr Lys Glu Pro Met 
    130                 135                 140                 


Leu Glu Glu Gly Leu Leu Glu Lys Met Tyr Asn Ile Phe Asp Asp Asn 
145                 150                 155                 160 


Ile Gln Leu Val Ile Lys Asp Tyr Gln His Asn Lys Asp Ile Asn Pro 
                165                 170                 175     


Asp Glu Asp Phe Lys His Leu Asp Arg Lys Gly Gln Phe Lys Tyr Ser 
            180                 185                 190         


Phe Ala Asp Asn Glu Gly Asn Ile Thr Glu Ser Gly Leu Leu Phe Phe 
        195                 200                 205             


Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Met Gln Gln Lys 
    210                 215                 220                 


Leu Thr Gly Phe Lys Asp Asn Arg Glu Ser Lys Lys Lys Met Thr His 
225                 230                 235                 240 


Glu Val Phe Cys Arg Ser Arg Met Leu Leu Pro Lys Leu Arg Leu Glu 
                245                 250                 255     


Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu Asn Glu Leu 
            260                 265                 270         


Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Arg Gly Asp Asp Arg 
        275                 280                 285             


Glu Lys Phe Arg Val Pro Leu Asp Pro Ile Asp Glu Asp Tyr Asp Ala 
    290                 295                 300                 


Glu Gln Glu Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
305                 310                 315                 320 


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Tyr Asn Glu Ile Phe Thr Asn 
                325                 330                 335     


Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile Tyr Lys 
            340                 345                 350         


Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg His Leu Thr His Lys Leu 
        355                 360                 365             


Tyr Gly Phe Glu Arg Ile Gln Glu Phe Asp Lys Gln Asn Arg Pro Asp 
    370                 375                 380                 


Glu Trp Lys Ala Leu Val Lys Asp Leu Asp Thr Tyr Glu Thr Ser Asn 
385                 390                 395                 400 


Glu Arg Tyr Ile Ser Glu Thr Thr Pro His Tyr His Leu Glu Asn Gln 
                405                 410                 415     


Lys Ile Gly Ile Arg Asn Lys Lys Lys Lys Lys Lys Lys Asn Ile Trp 
            420                 425                 430         


Pro Ser Leu Glu Ile Asn Thr Thr Val Asn Glu Arg Ser Lys Tyr Asn 
        435                 440                 445             


Leu Gly Lys Ser Phe Lys Ala Glu Ala Phe Leu Ser Val His Glu Leu 
    450                 455                 460                 


Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Thr Lys Glu Glu Pro Asn 
465                 470                 475                 480 


Asn Lys Glu Ile Asn Ala Ser Lys Val Glu Gly Ile Ile Glu Lys Lys 
                485                 490                 495     


Ile Arg Asp Met Tyr Lys Leu Tyr Asp Ala Phe Ala Asn Gly Glu Ile 
            500                 505                 510         


Asn Ser Lys Glu Glu Leu Lys Glu Tyr Leu Lys Gly Lys Asp Ile Glu 
        515                 520                 525             


Ile Val His Leu Pro Lys Gln Met Ile Ala Ile Leu Glu Ser Lys Pro 
    530                 535                 540                 


Lys Asp Met Val Lys Glu Ala Lys Arg Lys Gln Lys Glu Met Val Lys 
545                 550                 555                 560 


Asp Thr Lys Lys Leu Leu Ala Thr Leu Glu Lys Gln Thr Gln Gly Glu 
                565                 570                 575     


Ile Glu Asp Gly Gly Arg Asn Ile Arg Leu Leu Lys Ser Gly Glu Ile 
            580                 585                 590         


Ala Arg Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln Lys 
        595                 600                 605             


Asp Asn Glu Gly Asn Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu 
    610                 615                 620                 


Tyr Gln Met Leu Gln Arg Ser Leu Ala Leu Tyr Asn Lys Glu Glu Lys 
625                 630                 635                 640 


Pro Thr Arg Tyr Phe Arg Gln Val Asn Leu Ile Asn Ser Ser Asn Pro 
                645                 650                 655     


His Pro Phe Leu Lys Trp Thr Lys Trp Glu Glu Cys Asn Asn Ile Leu 
            660                 665                 670         


Ser Phe Tyr Arg Ser Tyr Leu Thr Lys Lys Ile Glu Phe Leu Asn Lys 
        675                 680                 685             


Leu Lys Pro Glu Asp Trp Glu Lys Asn Gln Tyr Phe Leu Lys Leu Lys 
    690                 695                 700                 


Glu Pro Lys Thr Asn Arg Glu Thr Leu Val Gln Gly Trp Lys Asn Gly 
705                 710                 715                 720 


Phe Asn Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg Glu Trp Phe 
                725                 730                 735     


Lys Arg His Gln Asn Asn Ser Glu Glu Tyr Lys Lys Val Glu Ala Leu 
            740                 745                 750         


Asp Arg Val Gly Leu Val Thr Lys Val Ile Pro Leu Phe Phe Lys Glu 
        755                 760                 765             


Glu Tyr Phe Lys Glu Asp Thr Gln Lys Glu Ile Asn Asn Cys Val Gln 
    770                 775                 780                 


Pro Phe Tyr Ser Phe Pro Tyr Asn Met Gly Asn Ile His Lys Pro Lys 
785                 790                 795                 800 


Glu Glu Asp Phe Leu His Arg Glu Glu Arg Ile Glu Leu Trp Asp Lys 
                805                 810                 815     


Lys Lys Asp Lys Phe Lys Gly Tyr Lys Ala Lys Val Lys Ser Lys Lys 
            820                 825                 830         


Leu Thr Asp Lys Glu Lys Glu Glu Tyr Arg Ser Tyr Leu Glu Phe Gln 
        835                 840                 845             


Ser Trp Asn Lys Phe Glu Arg Glu Leu Arg Leu Val Arg Asn Gln Asp 
    850                 855                 860                 


Ile Val Thr Trp Leu Leu Cys Thr Glu Leu Ile Asp Arg Leu Lys Ile 
865                 870                 875                 880 


Asp Glu Leu Asn Ile Glu Glu Leu Gln Lys Leu Arg Leu Lys Asp Ile 
                885                 890                 895     


Asp Thr Asp Thr Ala Lys Gln Glu Lys Asn Asn Ile Leu Asn Arg Ile 
            900                 905                 910         


Met Pro Met Gln Leu Pro Val Thr Val Tyr Glu Ile Asp Asp Ser His 
        915                 920                 925             


Lys Ile Val Lys Asp Lys Pro Leu His Thr Val Tyr Ile Glu Glu Thr 
    930                 935                 940                 


Glu Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys Asp 
945                 950                 955                 960 


Arg Arg Leu Asn Gly Leu Phe Ser Phe Val Asp Thr Ser Ser Glu Thr 
                965                 970                 975     


Glu Leu Lys Ser Lys Pro Ile Ser Lys Leu Arg Val Glu Tyr Glu Leu 
            980                 985                 990         


Gly Glu Tyr Gln Asn Ala Arg Ile  Glu Thr Ile Lys Asp  Met Leu Leu 
        995                 1000                 1005             


Leu Glu  Glu Thr Leu Ile Glu  Lys Tyr Lys Thr Leu  Pro Thr Asn 
    1010                 1015                 1020             


Lys Phe  Ser Ala Met Leu Asn  Gly Trp Leu Glu Gly  Lys Asp Glu 
    1025                 1030                 1035             


Ala Asp  Lys Ala Arg Phe Gln  Asn Asp Val Lys Leu  Leu Thr Ala 
    1040                 1045                 1050             


Val Arg  Asn Ala Phe Ser His  Asn Gln Tyr Pro Met  Arg Asn Arg 
    1055                 1060                 1065             


Ile Ala  Phe Ala Asn Ile Asn  Pro Phe Ser Leu Ser  Ser Ala Asn 
    1070                 1075                 1080             


Thr Ser  Glu Glu Lys Gly Leu  Asp Ile Ala Asn Gln  Leu Lys Asp 
    1085                 1090                 1095             


Lys Thr  His Lys Thr Ile Glu  Lys Ile Ile Glu Ile  Glu Lys Pro 
    1100                 1105                 1110             


Ile Glu  Thr Lys Glu 
    1115             


<210>  1563
<211>  1184
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1563

Met Glu Arg Ile Phe Gly His Cys Cys Pro His His Asp Ser Val Cys 
1               5                   10                  15      


Phe Val Arg Phe Leu Gly Thr Met Val Ser Asn Gln Asp Gly Arg Glu 
            20                  25                  30          


Asn Val Leu Asp Ile Leu Tyr Ile Ala Asp Arg Thr Arg Lys Leu Lys 
        35                  40                  45              


Pro Met Asn Thr Val Pro Ala Ser Glu Asn Lys Gly Gln Ser Arg Thr 
    50                  55                  60                  


Val Glu Asp Asp Pro Gln Tyr Phe Gly Leu Tyr Leu Asn Leu Ala Arg 
65                  70                  75                  80  


Glu Asn Leu Ile Glu Val Glu Ser His Val Arg Ile Lys Phe Gly Lys 
                85                  90                  95      


Lys Lys Leu Asn Glu Glu Ser Leu Lys Gln Ser Leu Leu Cys Asp His 
            100                 105                 110         


Leu Leu Ser Val Asp Arg Trp Thr Lys Val Tyr Gly His Ser Arg Arg 
        115                 120                 125             


Tyr Leu Pro Phe Leu His Tyr Phe Asp Pro Asp Ser Gln Ile Glu Lys 
    130                 135                 140                 


Asp His Asp Ser Lys Thr Gly Val Asp Pro Asp Ser Ala Gln Arg Leu 
145                 150                 155                 160 


Ile Arg Glu Leu Tyr Ser Leu Leu Asp Phe Leu Arg Asn Asp Phe Ser 
                165                 170                 175     


His Asn Arg Leu Asp Gly Thr Thr Phe Glu His Leu Glu Val Ser Pro 
            180                 185                 190         


Asp Ile Ser Ser Phe Ile Thr Gly Thr Tyr Ser Leu Ala Cys Gly Arg 
        195                 200                 205             


Ala Gln Ser Arg Phe Ala Asp Phe Phe Lys Pro Asp Asp Phe Val Leu 
    210                 215                 220                 


Ala Lys Asn Arg Lys Glu Gln Leu Ile Ser Val Ala Asp Gly Lys Glu 
225                 230                 235                 240 


Cys Leu Thr Val Ser Gly Leu Ala Phe Phe Ile Cys Leu Phe Leu Asp 
                245                 250                 255     


Arg Glu Gln Ala Ser Gly Met Leu Ser Arg Ile Arg Gly Phe Lys Arg 
            260                 265                 270         


Thr Asp Glu Asn Trp Ala Arg Ala Val His Glu Thr Phe Cys Asp Leu 
        275                 280                 285             


Cys Ile Arg His Pro His Asp Arg Leu Glu Ser Ser Asn Thr Lys Glu 
    290                 295                 300                 


Ala Leu Leu Leu Asp Met Leu Asn Glu Leu Asn Arg Cys Pro Arg Ile 
305                 310                 315                 320 


Leu Tyr Asp Met Leu Pro Glu Glu Glu Arg Ala Gln Phe Leu Pro Ala 
                325                 330                 335     


Leu Asp Glu Asn Ser Met Asn Asn Leu Ser Glu Asn Ser Leu Asn Glu 
            340                 345                 350         


Glu Ser Arg Leu Leu Trp Asp Gly Ser Ser Asp Trp Ala Glu Ala Leu 
        355                 360                 365             


Thr Lys Arg Ile Arg His Gln Asp Arg Phe Pro Tyr Leu Met Leu Arg 
    370                 375                 380                 


Phe Ile Glu Glu Met Asp Leu Leu Lys Gly Ile Arg Phe Arg Val Asp 
385                 390                 395                 400 


Leu Gly Glu Ile Glu Leu Asp Ser Tyr Ser Lys Lys Val Gly Arg Asn 
                405                 410                 415     


Gly Glu Tyr Asp Arg Thr Ile Thr Asp Tyr Ala Leu Ala Phe Gly Lys 
            420                 425                 430         


Leu Ser Asp Phe Gln Asn Glu Glu Glu Val Ser Arg Met Ile Ser Gly 
        435                 440                 445             


Glu Ala Ser Tyr Pro Val Arg Phe Ser Leu Phe Ala Pro Arg Tyr Ala 
    450                 455                 460                 


Ile Tyr Asp Asn Lys Ile Gly Tyr Cys His Thr Ser Asp Pro Val Tyr 
465                 470                 475                 480 


Pro Lys Ser Lys Thr Gly Glu Lys Arg Ala Leu Ser Asn Pro Gln Ser 
                485                 490                 495     


Met Gly Phe Ile Ser Val His Asp Leu Arg Lys Leu Leu Leu Met Glu 
            500                 505                 510         


Leu Leu Cys Glu Gly Ser Phe Ser Arg Met Gln Ser Asp Phe Leu Arg 
        515                 520                 525             


Lys Ala Asn Arg Ile Leu Asp Glu Thr Ala Glu Gly Lys Leu Gln Phe 
    530                 535                 540                 


Ser Ala Leu Phe Pro Glu Met Arg His Arg Phe Ile Pro Pro Gln Asn 
545                 550                 555                 560 


Pro Lys Ser Lys Asp Arg Arg Glu Lys Ala Glu Thr Thr Leu Glu Lys 
                565                 570                 575     


Tyr Lys Gln Glu Ile Lys Gly Arg Lys Asp Lys Leu Asn Ser Gln Leu 
            580                 585                 590         


Leu Ser Ala Phe Asp Met Asp Gln Arg Gln Leu Pro Ser Arg Leu Leu 
        595                 600                 605             


Asp Glu Trp Met Asn Ile Arg Pro Ala Ser His Ser Val Lys Leu Arg 
    610                 615                 620                 


Thr Tyr Val Lys Gln Leu Asn Glu Asp Cys Arg Leu Arg Leu Arg Lys 
625                 630                 635                 640 


Phe Arg Lys Asp Gly Asp Gly Lys Ala Arg Ala Ile Pro Leu Val Gly 
                645                 650                 655     


Glu Met Ala Thr Phe Leu Ser Gln Asp Ile Val Arg Met Ile Ile Ser 
            660                 665                 670         


Glu Glu Thr Lys Lys Leu Ile Thr Ser Ala Tyr Tyr Asn Glu Met Gln 
        675                 680                 685             


Arg Ser Leu Ala Gln Tyr Ala Gly Glu Glu Asn Arg Arg Gln Phe Arg 
    690                 695                 700                 


Ala Ile Val Ala Glu Leu His Leu Leu Asp Pro Ser Ser Gly His Pro 
705                 710                 715                 720 


Phe Leu Ser Ala Thr Met Glu Thr Ala His Arg Tyr Thr Glu Asp Phe 
                725                 730                 735     


Tyr Lys Cys Tyr Leu Glu Lys Lys Arg Glu Trp Leu Ala Lys Thr Phe 
            740                 745                 750         


Tyr Arg Pro Glu Gln Asp Glu Asn Thr Lys Arg Arg Ile Ser Val Phe 
        755                 760                 765             


Phe Val Pro Asp Gly Glu Ala Arg Lys Leu Leu Pro Leu Leu Ile Arg 
    770                 775                 780                 


Arg Arg Met Lys Glu Gln Asn Asp Leu Gln Asp Trp Ile Arg Asn Lys 
785                 790                 795                 800 


Gln Ala His Pro Ile Asp Leu Pro Ser His Leu Phe Asp Ser Lys Val 
                805                 810                 815     


Met Glu Leu Leu Lys Val Lys Asp Gly Lys Lys Lys Trp Asn Glu Ala 
            820                 825                 830         


Phe Lys Asp Trp Trp Ser Thr Lys Tyr Pro Asp Gly Met Gln Pro Phe 
        835                 840                 845             


Tyr Gly Leu Arg Arg Glu Leu Asn Ile His Gly Lys Ser Val Ser Tyr 
    850                 855                 860                 


Ile Pro Ser Asp Gly Lys Lys Phe Ala Asp Cys Tyr Thr His Leu Met 
865                 870                 875                 880 


Glu Lys Thr Val Arg Asp Lys Lys Arg Glu Leu Arg Thr Ala Gly Lys 
                885                 890                 895     


Pro Val Pro Pro Asp Leu Ala Ala Asp Ile Lys Arg Ser Phe His Arg 
            900                 905                 910         


Ala Val Asn Glu Arg Glu Phe Met Leu Arg Leu Val Gln Glu Asp Asp 
        915                 920                 925             


Arg Leu Met Leu Met Ala Ile Asn Lys Met Met Thr Asp Arg Glu Glu 
    930                 935                 940                 


Asp Ile Leu Pro Gly Leu Lys Asn Ile Asp Ser Ile Leu Asp Glu Glu 
945                 950                 955                 960 


Asn Gln Phe Ser Leu Ala Val His Ala Lys Val Leu Glu Lys Glu Gly 
                965                 970                 975     


Glu Gly Gly Asp Asn Ser Leu Ser Leu Val Pro Ala Thr Ile Val Ile 
            980                 985                 990         


Lys Ser Lys Arg Lys Asp Trp Ser  Lys Tyr Ile Arg Tyr  Arg Tyr Asp 
        995                 1000                 1005             


Arg Arg  Val Pro Gly Leu Met  Ser His Phe Pro Glu  His Lys Ala 
    1010                 1015                 1020             


Thr Leu  Asp Glu Val Lys Thr  Leu Leu Gly Glu Tyr  Asp Arg Cys 
    1025                 1030                 1035             


Arg Ile  Lys Ile Phe Asp Trp  Ala Phe Ala Leu Glu  Gly Ala Ile 
    1040                 1045                 1050             


Met Ser  Asp Arg Asp Leu Lys  Pro Tyr Leu His Glu  Ser Ser Ser 
    1055                 1060                 1065             


Arg Glu  Gly Lys Ser Gly Glu  His Ser Thr Leu Val  Lys Met Leu 
    1070                 1075                 1080             


Val Glu  Lys Lys Gly Cys Leu  Thr Pro Asp Glu Ser  Gln Tyr Leu 
    1085                 1090                 1095             


Ile Leu  Ile Arg Asn Lys Ala  Ala His Asn Gln Phe  Pro Cys Ala 
    1100                 1105                 1110             


Ala Glu  Met Pro Leu Ile Tyr  Arg Asp Val Ser Ala  Lys Val Gly 
    1115                 1120                 1125             


Ser Ile  Glu Gly Ser Ser Ala  Lys Asp Leu Pro Glu  Gly Ser Ser 
    1130                 1135                 1140             


Leu Val  Asp Ser Leu Trp Lys  Lys Tyr Glu Met Ile  Ile Arg Lys 
    1145                 1150                 1155             


Ile Leu  Pro Ile Leu Asp Pro  Glu Asn Arg Phe Phe  Gly Lys Leu 
    1160                 1165                 1170             


Leu Asn  Asn Met Ser Gln Pro  Ile Asn Asp Leu 
    1175                 1180                 


<210>  1564
<211>  1119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1564

Met Thr Glu Gln Asn Glu Lys Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Ala His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Lys Tyr Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Gly Lys Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Thr Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Phe Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Asp Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Gly Glu Ile Asp Thr Leu Asp 
    530                 535                 540                 


Arg Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Ile Arg Lys Lys Leu Gln Glu Met Met Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Gly Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly His Asp Glu Val Ala Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Leu Ala Lys Leu Lys Lys Glu Ile Leu Glu Ala 
        835                 840                 845             


Lys Glu His Pro Tyr His Asp Phe Lys Ser Trp Gln Lys Phe Glu Arg 
    850                 855                 860                 


Glu Leu Arg Leu Val Lys Asn Gln Asp Ile Ile Thr Trp Met Met Cys 
865                 870                 875                 880 


Arg Asp Leu Met Glu Glu Asn Lys Val Glu Gly Leu Asp Thr Gly Thr 
                885                 890                 895     


Leu Tyr Leu Lys Asp Ile Arg Thr Asp Val His Glu Gln Gly Ser Leu 
            900                 905                 910         


Asn Val Leu Asn Arg Val Lys Pro Met Arg Leu Pro Val Val Val Tyr 
        915                 920                 925             


Arg Ala Asp Ser Arg Gly His Val His Lys Glu Gln Ala Pro Leu Ala 
    930                 935                 940                 


Thr Val Tyr Ile Glu Glu Arg Asp Thr Lys Leu Leu Lys Gln Gly Asn 
945                 950                 955                 960 


Phe Lys Ser Phe Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe 
                965                 970                 975     


Val Asp Thr Gly Gly Leu Ala Met Glu Gln Tyr Pro Ile Ser Lys Leu 
            980                 985                 990         


Arg Val Glu Tyr Glu Leu Ala Lys  Tyr Gln Thr Ala Arg  Val Cys Ala 
        995                 1000                 1005             


Phe Glu  Gln Thr Leu Glu Leu  Glu Glu Ser Leu Leu  Thr Arg Tyr 
    1010                 1015                 1020             


Pro His  Leu Pro Asp Glu Asn  Phe Arg Lys Met Leu  Glu Ser Trp 
    1025                 1030                 1035             


Ser Asp  Pro Leu Leu Asp Lys  Trp Pro Asp Leu His  Arg Lys Val 
    1040                 1045                 1050             


Arg Leu  Leu Ile Ala Val Arg  Asn Ala Phe Ser His  Asn Gln Tyr 
    1055                 1060                 1065             


Pro Met  Tyr Asp Glu Ala Val  Phe Ser Ser Ile Arg  Lys Tyr Asp 
    1070                 1075                 1080             


Pro Ser  Ser Pro Asp Ala Ile  Glu Glu Arg Met Gly  Leu Asn Ile 
    1085                 1090                 1095             


Ala His  Arg Leu Ser Glu Glu  Val Lys Gln Ala Lys  Glu Met Ala 
    1100                 1105                 1110             


Glu Arg  Ile Ile Gln Ala 
    1115                 


<210>  1565
<211>  1171
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1565

Met Asn Leu Leu Glu Lys Thr Asn Ala Ala Glu Ser Cys Phe Asn His 
1               5                   10                  15      


Thr Ile Asn Asp Gln Lys Tyr Tyr Phe Ala Gly Tyr Leu Asn Leu Ala 
            20                  25                  30          


Gln Asn Asn Ile Lys Thr Leu Glu Lys Ala Tyr Gly Glu His Phe Leu 
        35                  40                  45              


Cys Ser Gly Asn Asn Pro Ile Ile Asn Asp Leu Thr Asn Thr Asn Ser 
    50                  55                  60                  


Leu Ile Asp Trp Asp Phe Lys Met Lys Phe Leu Ser Gln Tyr Leu Pro 
65                  70                  75                  80  


Ala Ile Ser Tyr Leu Asn Leu Glu Thr Asp Leu Asn Glu Ser Phe Glu 
                85                  90                  95      


Lys Arg Lys Lys Glu Phe Thr Lys Asn Leu Ser Phe Leu Phe Asn Ala 
            100                 105                 110         


Ile Asp Leu Leu Arg Asn Phe Tyr Ser His Tyr Tyr His Ala Pro Leu 
        115                 120                 125             


Ile Asp Glu Leu Asn Ser Glu Arg Leu Ile Phe Leu Asp Lys Ile Phe 
    130                 135                 140                 


Val Ala Val Cys Ile Asn Val Lys Lys Lys Arg Met Lys Asp Asp Lys 
145                 150                 155                 160 


Thr Lys Gln Leu Leu Lys Ala Thr Leu Ile Asp Glu Leu Asp Leu Leu 
                165                 170                 175     


Leu Lys Ala Lys Lys Glu Glu Leu Leu Lys Lys Lys Lys Glu Gly Lys 
            180                 185                 190         


Lys Val Ser Thr Asp Ala Ile Ser Met Lys Asn Ser Val Leu Asn Asp 
        195                 200                 205             


Ala Phe Asn His Leu Ile Gln Leu Glu Lys Asn Ser Lys Lys Glu Ile 
    210                 215                 220                 


Pro Gly Arg Tyr Tyr Thr Ser Leu Leu Asn Asp Asn Asn Lys Tyr Thr 
225                 230                 235                 240 


Glu Asn Gly Ile Asn Ile Ser Ile Ser Gly Leu Leu Phe Leu Leu Ser 
                245                 250                 255     


Met Phe Leu Thr Lys Lys Gln Asn Glu Asp Val Arg Ser Arg Ile Phe 
            260                 265                 270         


Gly Phe Lys Gly Thr Ile Glu Ser Asp Lys Gly Ile Ser Lys Ser Asn 
        275                 280                 285             


Asn Ser Phe Arg Asn Met Ala Thr Asn Trp Val Phe Ser Tyr Leu Ser 
    290                 295                 300                 


Phe Lys Gly Met Lys Lys Gln Leu Gly Ser Thr Phe Asn Lys Glu Ser 
305                 310                 315                 320 


Leu Leu Val Gln Ile Val Asp Glu Leu Ser Lys Val Pro His Glu Val 
                325                 330                 335     


Tyr Gln Thr Leu Ser Pro Ser Arg Gln Glu Met Phe Leu Glu Asp Met 
            340                 345                 350         


Asn Glu Tyr Leu Lys Asp Gly Asn Lys Lys His Cys Leu Glu Asp Ser 
        355                 360                 365             


Ile Val Val His Pro Val Ile Lys Lys Arg Tyr Glu Asp Lys Phe Asn 
    370                 375                 380                 


Tyr Phe Ala Ile Arg Tyr Leu Asp Glu Phe Val Asp Phe Pro Ser Leu 
385                 390                 395                 400 


Arg Phe Gln Val Asn Val Gly Asn Tyr Val His Asp Arg Arg Lys Lys 
                405                 410                 415     


Thr Ile Asp Gly Thr Asn Thr Glu Thr Asp Arg Met Val Lys Glu Glu 
            420                 425                 430         


Ile Arg Ala Phe Gly Lys Leu Ser Phe Ile Ser Lys Leu Lys Ala Asp 
        435                 440                 445             


Tyr Phe Ala Lys Asp Leu Pro Ser Asp Ile Ser Trp Glu Met Tyr Pro 
    450                 455                 460                 


Asn Pro Ser Tyr Asn Phe Ser Ala Asn Asn Ile Pro Val Tyr Ile Asp 
465                 470                 475                 480 


Leu Phe Lys Ser Ser Val Ala Gly Ala Ala Asp Val Gly Lys Asp His 
                485                 490                 495     


Lys Gly Tyr Gln Ala Lys Leu Asp Leu Asp Glu Asp Gly Lys Lys Arg 
            500                 505                 510         


Asn Arg Asn Glu Gly Lys Pro Asp Lys Lys Glu Ile Ala Glu Ile Leu 
        515                 520                 525             


Phe Gly Lys Lys Asn Lys Gln Ile Leu Phe Glu Lys Pro Thr Val Leu 
    530                 535                 540                 


Leu Ser Leu Asn Glu Leu Pro Ala Met Leu Tyr Glu Val Leu Ile Glu 
545                 550                 555                 560 


Asn Gly Asp Lys Gln Asp Ile Gly Lys Arg Ile Glu Asp Lys Ile Val 
                565                 570                 575     


Glu Lys Ile Ile Ala His Tyr Asn Leu Leu Asp Gln Tyr Asp Gly Thr 
            580                 585                 590         


Thr Glu Leu Pro Gly Ser Val Ile Pro Arg Lys Leu Arg Met Gly Gly 
        595                 600                 605             


Asn Glu Lys Ser Ile Asn Ile Asp Lys Leu Leu Arg Ala Val Lys Arg 
    610                 615                 620                 


Glu Leu Glu Ile Thr Gln Glu Lys Leu Asp Leu Ile Lys Thr Asn Gln 
625                 630                 635                 640 


Lys Lys Phe Lys Ser Lys Glu Lys Asp Glu Lys Gly Asn Ser Arg Gln 
                645                 650                 655     


His Val Phe Tyr Thr Asn Glu Leu Gly Gln Glu Ala Thr Trp Ile Ala 
            660                 665                 670         


Asn Asp Met Lys Arg Phe Met Pro Lys Glu Val Lys Glu Lys Trp Arg 
        675                 680                 685             


Gly Tyr His His Ser Asn Leu Gln Lys Leu Leu Ala Leu Tyr Asp Gln 
    690                 695                 700                 


Thr Arg Asn Glu Ala Val Lys Cys Ile Thr Cys Phe Trp Asn Phe Asp 
705                 710                 715                 720 


Gln Gln Thr Ser Trp Gly Lys Gly Ile Lys Glu Ala Phe Tyr Lys Ser 
                725                 730                 735     


Thr Phe Glu Glu Phe Tyr Lys Ala Tyr Leu Glu His Arg Met Asp Val 
            740                 745                 750         


Tyr Lys Thr Leu Glu Asn Asn Leu Ile Ala Gly Lys Gly Tyr Ser Lys 
        755                 760                 765             


Leu Phe Asn Lys Glu Lys Lys Lys Ala Phe Ile Leu Phe Asp Glu His 
    770                 775                 780                 


Leu Tyr Thr Ile Pro Asp Ile Asn Thr Gln Lys Glu Arg Leu Lys Ser 
785                 790                 795                 800 


Thr Leu Phe Ile Leu Pro Arg Gly Ile Phe Asp Ser Lys Pro Thr Phe 
                805                 810                 815     


Ile Lys Gly Ile Lys Tyr Glu Glu Asp Pro Ser Cys Phe Ala Asp Trp 
            820                 825                 830         


Tyr Gln Phe Ala Asn Ala Thr Gly Asn Gln Tyr Gln Arg Phe Tyr Asp 
        835                 840                 845             


Leu Pro Arg Ser Tyr Thr Ser Leu Phe Glu Glu Thr Lys Lys Asn Asn 
    850                 855                 860                 


Glu Gly Leu Ile Glu Asn Lys Lys Gly Leu Ser Ala Lys Glu Gln Leu 
865                 870                 875                 880 


Asp Phe Phe Lys Met Arg Gln Asp Leu Lys Ile Lys Lys Ile Lys Thr 
                885                 890                 895     


Gln Asp Leu Phe Leu Phe Met Ile Val Arg Asp Leu Tyr Lys Lys Val 
            900                 905                 910         


Phe Asp His Thr Leu Pro Leu Glu Ile Gly Leu Arg Asp Met Tyr Gln 
        915                 920                 925             


Thr Pro Ala Glu Arg Gln Ala Asn Tyr Asp Leu Ala Val Lys Gln Ser 
    930                 935                 940                 


Gln Arg Thr Glu Gly Asp Asn Ser Asp Asn Leu Tyr Asn Tyr Asn Phe 
945                 950                 955                 960 


Leu Trp Asn Leu Thr Ile Pro Phe Glu Tyr Asp Lys Ile Lys Glu Pro 
                965                 970                 975     


Gln Val Lys Leu Lys Asp Val Gly Lys Phe Tyr Lys Phe Ala Ala Asp 
            980                 985                 990         


Glu Lys Val Gln Thr Ile Leu Ser  Tyr Ser Asp Arg Glu  Trp Ser Lys 
        995                 1000                 1005             


Leu Asp  Leu Glu Lys Glu Leu  Glu Leu Met Pro Thr  Ser Tyr Glu 
    1010                 1015                 1020             


Val Ile  Arg Arg Glu Gln Leu  Leu Arg Asp Ile Gln  Gln Phe Glu 
    1025                 1030                 1035             


Lys Arg  Ile Leu Glu Asn Tyr  Pro Ser Asp Gly Asn  Ala His Pro 
    1040                 1045                 1050             


Ala Asp  Leu Glu Lys Glu Asp  Lys Asp Lys Lys Cys  Phe Pro Asn 
    1055                 1060                 1065             


Phe Asn  Leu Tyr Leu Leu Lys  Gly Ile Ile Ile Lys  Asn Asn Leu 
    1070                 1075                 1080             


Ala Ser  Glu Glu Glu Arg Gln  Trp Phe Glu Gln Val  His Leu Asp 
    1085                 1090                 1095             


Lys Thr  Pro Phe Tyr Pro Glu  Val Glu Thr Lys Ser  Ser Ile Ile 
    1100                 1105                 1110             


Gln Ser  Ala Tyr Leu Leu Leu  Leu Ile Arg Asn Lys  Met Leu His 
    1115                 1120                 1125             


Asn Gln  Leu Pro Ser Lys Gln  Asn Phe Glu Phe Met  Thr Thr Leu 
    1130                 1135                 1140             


Tyr Pro  Phe Glu Gly Tyr Glu  Ser Tyr Ser Thr Tyr  Leu Leu Phe 
    1145                 1150                 1155             


Val Thr  Lys Lys Thr Ile Glu  Cys Leu Ser Ser Ala  Met 
    1160                 1165                 1170     


<210>  1566
<211>  1171
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1566

Met Asn Leu Leu Glu Lys Thr Asn Ala Ala Glu Ser Cys Phe Asn His 
1               5                   10                  15      


Thr Ile Asn Asp Gln Lys Tyr Tyr Phe Ala Gly Tyr Leu Asn Leu Ala 
            20                  25                  30          


Gln Asn Asn Ile Lys Thr Leu Glu Lys Ala Tyr Gly Glu His Phe Leu 
        35                  40                  45              


Cys Ser Gly Asn Asn Pro Ile Ile Asn Asp Leu Thr Asn Thr Asn Ser 
    50                  55                  60                  


Leu Ile Asp Trp Asp Phe Lys Met Lys Phe Leu Ser Gln Tyr Leu Pro 
65                  70                  75                  80  


Ala Ile Ser Tyr Leu Asn Leu Glu Thr Asp Leu Asn Glu Ser Phe Glu 
                85                  90                  95      


Lys Arg Lys Lys Glu Phe Thr Lys Asn Leu Ser Phe Leu Phe Asn Ala 
            100                 105                 110         


Ile Asp Leu Leu Arg Asn Phe Tyr Ser His Tyr Tyr His Ala Pro Leu 
        115                 120                 125             


Ile Asp Glu Leu Asn Ser Glu Arg Leu Ile Phe Leu Asp Lys Ile Phe 
    130                 135                 140                 


Val Ala Val Cys Ile Asn Val Lys Lys Lys Arg Met Lys Asp Asp Lys 
145                 150                 155                 160 


Thr Lys Gln Leu Leu Lys Ala Thr Leu Ile Asp Glu Leu Asp Leu Leu 
                165                 170                 175     


Leu Lys Ala Lys Lys Glu Glu Leu Leu Lys Lys Lys Lys Glu Gly Lys 
            180                 185                 190         


Lys Val Ser Thr Asp Ala Ile Ser Met Lys Asn Ser Val Leu Asn Asp 
        195                 200                 205             


Ala Phe Asn His Leu Ile Gln Leu Glu Lys Asn Ser Lys Lys Glu Ile 
    210                 215                 220                 


Pro Gly Arg Tyr Tyr Thr Ser Leu Leu Asn Asp Asn Asn Lys Tyr Thr 
225                 230                 235                 240 


Glu Asn Gly Ile Asn Ile Ser Ile Ser Gly Leu Leu Phe Leu Leu Ser 
                245                 250                 255     


Met Phe Leu Thr Lys Lys Gln Asn Glu Asp Val Arg Ser Arg Ile Phe 
            260                 265                 270         


Gly Phe Lys Gly Thr Ile Glu Ser Asp Lys Gly Ile Ser Lys Ser Asn 
        275                 280                 285             


Asn Ser Phe Arg Asn Met Ala Thr Asn Trp Val Phe Ser Tyr Leu Ser 
    290                 295                 300                 


Phe Lys Gly Met Lys Lys Gln Leu Gly Ser Thr Phe Asn Lys Glu Ser 
305                 310                 315                 320 


Leu Leu Val Gln Ile Val Asp Glu Leu Ser Lys Val Pro His Glu Val 
                325                 330                 335     


Tyr Gln Thr Leu Ser Pro Ser Arg Gln Glu Met Phe Leu Glu Asp Met 
            340                 345                 350         


Asn Glu Tyr Leu Lys Asp Gly Asn Lys Lys His Cys Leu Glu Asp Ser 
        355                 360                 365             


Ile Val Val His Pro Val Ile Lys Lys Arg Tyr Glu Asp Lys Phe Asn 
    370                 375                 380                 


Tyr Phe Ala Ile Arg Tyr Leu Asp Glu Phe Val Asp Phe Pro Ser Leu 
385                 390                 395                 400 


Arg Phe Gln Val Asn Val Gly Asn Tyr Val His Asp Arg Arg Lys Lys 
                405                 410                 415     


Thr Ile Asp Gly Thr Asn Thr Glu Thr Asp Arg Met Val Lys Glu Glu 
            420                 425                 430         


Ile Arg Ala Phe Gly Lys Leu Ser Phe Ile Ser Lys Leu Lys Ala Asp 
        435                 440                 445             


Tyr Phe Ala Lys Asp Leu Pro Ser Asp Ile Ser Trp Glu Met Tyr Pro 
    450                 455                 460                 


Asn Pro Ser Tyr Asn Phe Ser Ala Asn Asn Ile Pro Val Tyr Ile Asp 
465                 470                 475                 480 


Leu Phe Lys Ser Ser Val Ala Gly Ala Ala Asp Val Gly Lys Asp His 
                485                 490                 495     


Lys Gly Tyr Gln Ala Lys Leu Asp Leu Asp Glu Asp Gly Lys Lys Arg 
            500                 505                 510         


Asn Arg Asn Glu Gly Lys Pro Asp Lys Lys Glu Ile Ala Glu Ile Leu 
        515                 520                 525             


Phe Gly Lys Lys Asn Lys Gln Ile Leu Phe Glu Lys Pro Thr Val Leu 
    530                 535                 540                 


Leu Ser Leu Asn Glu Leu Pro Ala Met Leu Tyr Glu Val Leu Ile Glu 
545                 550                 555                 560 


Asn Gly Asp Lys Gln Asp Ile Gly Lys Arg Ile Glu Asp Lys Ile Val 
                565                 570                 575     


Glu Lys Ile Ile Ala His Tyr Asn Leu Leu Asp Gln Tyr Asp Gly Thr 
            580                 585                 590         


Thr Glu Leu Pro Gly Ser Val Ile Pro Arg Lys Leu Arg Met Gly Gly 
        595                 600                 605             


Asn Glu Lys Ser Ile Asn Ile Asp Lys Leu Leu Arg Ala Val Lys Arg 
    610                 615                 620                 


Glu Leu Glu Ile Thr Gln Glu Lys Leu Asp Leu Ile Lys Thr Asn Gln 
625                 630                 635                 640 


Lys Lys Phe Lys Ser Lys Glu Lys Asp Glu Lys Gly Asn Ser Arg Gln 
                645                 650                 655     


His Val Phe Tyr Thr Asn Glu Leu Gly Gln Glu Ala Thr Trp Ile Ala 
            660                 665                 670         


Asn Asp Met Lys Arg Phe Met Pro Lys Glu Val Lys Glu Lys Trp Arg 
        675                 680                 685             


Gly Tyr His His Ser Asn Leu Gln Lys Leu Leu Ala Leu Tyr Asp Gln 
    690                 695                 700                 


Thr Arg Asn Glu Ala Val Lys Cys Ile Thr Cys Phe Trp Asn Phe Asp 
705                 710                 715                 720 


Gln Gln Thr Ser Trp Gly Lys Gly Ile Lys Glu Ala Phe Tyr Lys Ser 
                725                 730                 735     


Thr Phe Glu Glu Phe Tyr Lys Ala Tyr Leu Glu His Arg Met Asp Val 
            740                 745                 750         


Tyr Lys Thr Leu Glu Asn Asn Leu Ile Ala Gly Lys Gly Tyr Ser Lys 
        755                 760                 765             


Leu Phe Asn Lys Glu Lys Lys Lys Ala Phe Ile Leu Phe Asp Glu His 
    770                 775                 780                 


Leu Tyr Thr Ile Pro Asp Ile Asn Thr Gln Lys Glu Arg Leu Lys Ser 
785                 790                 795                 800 


Thr Leu Phe Ile Leu Pro Arg Gly Ile Phe Asp Ser Lys Pro Thr Phe 
                805                 810                 815     


Ile Lys Gly Ile Lys Tyr Glu Glu Asp Pro Ser Cys Phe Ala Asp Trp 
            820                 825                 830         


Tyr Gln Phe Ala Asn Ala Thr Gly Asn Gln Tyr Gln Arg Phe Tyr Asp 
        835                 840                 845             


Leu Pro Arg Ser Tyr Thr Ser Leu Phe Glu Glu Thr Lys Lys Asn Asn 
    850                 855                 860                 


Glu Gly Leu Ile Glu Asn Lys Lys Gly Leu Ser Ala Lys Glu Gln Leu 
865                 870                 875                 880 


Asp Phe Phe Lys Met Arg Gln Asp Leu Lys Ile Lys Lys Ile Lys Thr 
                885                 890                 895     


Gln Asp Leu Phe Leu Phe Met Ile Val Arg Asp Leu Tyr Lys Lys Val 
            900                 905                 910         


Phe Asp His Thr Leu Pro Leu Glu Ile Gly Leu Arg Asp Met Tyr Gln 
        915                 920                 925             


Thr Pro Ala Glu Arg Gln Ala Asn Tyr Asp Leu Ala Val Lys Gln Ser 
    930                 935                 940                 


Gln Arg Thr Glu Gly Asp Asn Ser Asp Asn Leu Tyr Asn Tyr Asn Phe 
945                 950                 955                 960 


Leu Trp Asn Leu Thr Ile Pro Phe Glu Tyr Asp Lys Ile Lys Glu Pro 
                965                 970                 975     


Gln Val Lys Leu Lys Asp Val Gly Lys Phe Tyr Lys Phe Ala Ala Asp 
            980                 985                 990         


Glu Lys Val Gln Thr Ile Leu Ser  Tyr Ser Asp Arg Glu  Trp Ser Lys 
        995                 1000                 1005             


Leu Asp  Leu Glu Lys Glu Leu  Glu Leu Met Pro Thr  Ser Tyr Glu 
    1010                 1015                 1020             


Val Ile  Arg Arg Glu Gln Leu  Leu Arg Asp Ile Gln  Gln Phe Glu 
    1025                 1030                 1035             


Lys Arg  Ile Leu Glu Asn Tyr  Pro Ser Asp Gly Asn  Ala His Pro 
    1040                 1045                 1050             


Ala Asp  Leu Glu Lys Glu Asp  Lys Asp Lys Lys Cys  Phe Pro Asn 
    1055                 1060                 1065             


Phe Asn  Leu Tyr Leu Leu Lys  Gly Ile Ile Ile Lys  Asn Asn Leu 
    1070                 1075                 1080             


Ala Ser  Glu Glu Glu Arg Gln  Trp Phe Glu Gln Val  His Leu Asp 
    1085                 1090                 1095             


Lys Thr  Pro Phe Tyr Pro Glu  Val Glu Thr Lys Ser  Ser Ile Ile 
    1100                 1105                 1110             


Gln Ser  Ala Tyr Leu Leu Leu  Leu Ile Arg Asn Lys  Met Leu His 
    1115                 1120                 1125             


Asn Gln  Leu Pro Ser Lys Gln  Asn Phe Glu Phe Met  Thr Thr Leu 
    1130                 1135                 1140             


Tyr Pro  Phe Glu Gly Tyr Glu  Ser Tyr Ser Thr Tyr  Leu Leu Phe 
    1145                 1150                 1155             


Val Thr  Lys Lys Thr Ile Glu  Cys Leu Ser Ser Ala  Met 
    1160                 1165                 1170     


<210>  1567
<211>  985
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1567

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Asn Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys Gly Tyr 
                165                 170                 175     


Ala Phe Phe Ile Ser Lys Phe Leu Glu Arg Lys Tyr Ser Tyr Leu Phe 
            180                 185                 190         


Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln Tyr Arg 
        195                 200                 205             


Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro Val Glu 
    210                 215                 220                 


Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu Asp Ile 
225                 230                 235                 240 


Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr Leu Glu 
                245                 250                 255     


Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr Asp Ala 
            260                 265                 270         


Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe Arg Ser 
        275                 280                 285             


Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala Asp Phe 
    290                 295                 300                 


Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His Asn Gly 
305                 310                 315                 320 


Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr Ile Asn 
                325                 330                 335     


Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser Ala Lys 
            340                 345                 350         


Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser Thr Asp 
        355                 360                 365             


Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln Ser Thr 
    370                 375                 380                 


Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val Leu Pro 
385                 390                 395                 400 


Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala Lys Met 
                405                 410                 415     


Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala Met Leu 
            420                 425                 430         


Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His Cys Pro 
        435                 440                 445             


Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser Thr Lys 
    450                 455                 460                 


Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg Val Met 
465                 470                 475                 480 


Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu Arg Ile 
                485                 490                 495     


Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile Leu Lys 
            500                 505                 510         


Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp Leu Gln 
        515                 520                 525             


Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn Phe Gln 
    530                 535                 540                 


Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn Asp Leu 
545                 550                 555                 560 


Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn Pro His 
                565                 570                 575     


Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile Glu Phe 
            580                 585                 590         


Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg Ile Gln 
        595                 600                 605             


Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro Leu Arg 
    610                 615                 620                 


Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu Ala Ile 
625                 630                 635                 640 


Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys Leu Lys 
                645                 650                 655     


Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu Lys Ser 
            660                 665                 670         


Pro Ala Leu Asn Val Ser Tyr Leu Ile His Asn Tyr Phe Arg Ala Tyr 
        675                 680                 685             


Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn Tyr Arg 
    690                 695                 700                 


Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser Tyr Leu 
705                 710                 715                 720 


Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro Ser Lys 
                725                 730                 735     


Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp Arg Leu 
            740                 745                 750         


Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile Ile Arg 
        755                 760                 765             


Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys Glu Tyr 
    770                 775                 780                 


Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu Glu Asn 
785                 790                 795                 800 


Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp Leu Asn 
                805                 810                 815     


Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr Gly Lys 
            820                 825                 830         


Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn Lys Val 
        835                 840                 845             


Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val Lys Ile 
    850                 855                 860                 


Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu Glu Ala 
865                 870                 875                 880 


Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala Met Val 
                885                 890                 895     


Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr Tyr Asp 
            900                 905                 910         


Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln Lys Ile 
        915                 920                 925             


Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His Asp Lys 
    930                 935                 940                 


Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val Tyr Ala 
945                 950                 955                 960 


Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile Lys Leu 
                965                 970                 975     


Glu Asp Leu Ser Asn Asp Ser Ser Ala 
            980                 985 


<210>  1568
<211>  1220
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1568

Met Ser Thr Arg Tyr Thr Asn Gln Lys Lys Val Glu Glu Asn Ile Asn 
1               5                   10                  15      


Tyr Val Phe Ser Asn Lys Gly Ile Phe Ala Ala Val Ala Glu Lys Thr 
            20                  25                  30          


Leu Thr Asn Tyr Lys Ser Lys Phe Asn Glu Gly Gln Thr Ile Gln Pro 
        35                  40                  45              


Asn Leu His Tyr Phe Ala Val Gly His Thr Phe Lys Asn Ile Asp Thr 
    50                  55                  60                  


Lys Arg Ile Phe Asp Tyr Gln Leu Ser Glu Asp Glu Met Asp Ile Leu 
65                  70                  75                  80  


Pro Thr Lys Tyr Phe Ser Leu Gln Gln Asn Lys Phe Ser Phe Pro Ile 
                85                  90                  95      


Asp Gly Gln Thr Lys Thr Asp Lys Leu Tyr Leu Leu Leu Asp Asn Ile 
            100                 105                 110         


Arg Asn Ile Asn Ala His Phe Ile His Asp Phe Asn Phe Leu Lys Val 
        115                 120                 125             


Asp Asn Ile Asp Glu Asn Ile Ile Cys Phe Leu Ile Asp Ser Phe Glu 
    130                 135                 140                 


Leu Ala Leu Ile Lys Gly Val Phe Ala Lys Lys Tyr Gly Asn Lys Lys 
145                 150                 155                 160 


His Glu Leu Gly Leu Asp Phe Leu Ser Asn Asp Leu Lys Asp Glu Ile 
                165                 170                 175     


Leu Glu Glu Ile Leu Glu Asn Leu Asp Asp Glu Leu Ile Val Phe Met 
            180                 185                 190         


Lys Glu Ile Phe Tyr Gln Thr Leu Tyr Val Val Asp Lys Lys Glu Trp 
        195                 200                 205             


Arg Asn Lys Glu Leu Asn Gln Glu Lys Lys Asp Phe Leu Asp Ser His 
    210                 215                 220                 


Leu Ser Ser Lys Glu Asp Trp Ile Asn Trp Ile Leu Phe Asn Cys Val 
225                 230                 235                 240 


Glu Glu Asp Ile Asp Trp Phe Leu Asn Asn Tyr Gly Asp Ser Asp Pro 
                245                 250                 255     


His Pro Asp Ser Lys Asn His Lys His Lys Val Leu Thr Ile Glu Lys 
            260                 265                 270         


Gly Lys His Leu Ser Phe Glu Gly Ser Leu Phe Met Met Thr Met Phe 
        275                 280                 285             


Leu Tyr Ala Asn Glu Ala Asn Tyr Leu Ile Pro Lys Leu Lys Gly Tyr 
    290                 295                 300                 


Lys Lys Asn Gly Thr Pro Gln Asp Ala Ser Lys Leu Glu Val Phe Arg 
305                 310                 315                 320 


Phe Phe Ala Lys Lys Phe Lys Ser Gln Asp Val Asp Ser Glu His Lys 
                325                 330                 335     


Gln Tyr Val Lys Phe Arg Asp Met Ile Gln Tyr Val Gly Lys Tyr Pro 
            340                 345                 350         


Thr Val Trp Asn Lys His Ile His Leu Asp Asn Tyr Tyr Val Asn Glu 
        355                 360                 365             


Leu Lys Val Ser Ile Leu Glu Asn Glu Ile Thr Gln Leu Phe Glu Gln 
    370                 375                 380                 


Asp Ile Gln Asn Tyr Phe Glu Thr Lys Tyr Gly Leu Gln Lys Phe Ala 
385                 390                 395                 400 


Lys Ala Lys Gly Asp Met His Tyr Ala Phe Val Glu Val Ala Lys Ser 
                405                 410                 415     


Tyr Leu Gln Lys Lys Thr Ile Ser Tyr Lys Gly Lys Tyr Gln Asp Asp 
            420                 425                 430         


Ser Ile Ala Ile Leu Glu Thr Leu Ala Glu Gln Ile Thr Asn Lys Arg 
        435                 440                 445             


Gln Leu Lys Asn Ile Glu Val Lys Leu Leu Arg Phe Ser Asp Thr Asp 
    450                 455                 460                 


Tyr Gln Ser Leu Ser Ser Ile Glu Lys Thr Lys Lys Gln Arg Leu Asp 
465                 470                 475                 480 


Lys Ser Lys Lys Met Phe Leu Asp Lys Ile Lys Glu Ser Lys Lys Thr 
                485                 490                 495     


Ile Asn Lys Thr Thr Glu Lys Phe Ala Lys Arg Val Glu Asp Asn Leu 
            500                 505                 510         


Leu Tyr Ile Ser Asn Gly Arg Asn Ser Asp Arg Phe Met Val Phe Ala 
        515                 520                 525             


Cys Arg Phe Leu Ala Glu Ile Asn Tyr Phe Gly Lys Asp Ala Gln Phe 
    530                 535                 540                 


Lys Met Tyr Glu Asn Tyr Tyr Ser Glu Glu Glu Gln Asn Ala Leu Lys 
545                 550                 555                 560 


Asp Lys Lys Gln Asn Leu Thr Gln Lys Asp Phe Asp Lys Leu His Tyr 
                565                 570                 575     


His Trp Gly Lys Leu Thr His Phe Glu Thr Phe Glu Asn His Val Lys 
            580                 585                 590         


Lys Tyr Pro Asn Trp Asp Met Pro Phe Val Val Gln Asn Asn Ala Ile 
        595                 600                 605             


Tyr Val Lys Ile Pro Gly Ile Asn Phe Ile Lys Asn Thr Ala Phe Cys 
    610                 615                 620                 


Ile Arg Arg Asn Val Ile Asn Tyr Leu Leu Glu His Ala Leu Gly Glu 
625                 630                 635                 640 


Asn Tyr Lys Asp Gln Gln Gly Arg Glu Trp Leu Phe Asp Tyr Tyr Glu 
                645                 650                 655     


Tyr Lys Thr Glu Ala Thr Asp Asn Ala Lys Arg Ile Leu Thr Glu Ser 
            660                 665                 670         


Lys Pro Ile Glu Ala Ser Ser Lys Thr Gln Leu Lys Lys Leu Leu Pro 
        675                 680                 685             


Lys Lys Leu Leu Pro Lys His Ser Pro Leu Glu Thr Glu Asn Lys Glu 
    690                 695                 700                 


Asn Ile Phe Arg Lys Tyr Leu Glu Gln Ala Glu Glu Ser Glu Lys Leu 
705                 710                 715                 720 


Tyr Glu Asn Gln Lys Asp Lys Ala Lys Ala Glu Lys Lys Leu Asp Leu 
                725                 730                 735     


Phe Val Asn Lys Asn Lys Gly Lys Gln Phe Lys Leu Arg Phe Ile Phe 
            740                 745                 750         


Lys Ala Trp Gln Leu Met Tyr Phe Lys Lys Gln Tyr Gln Ile Glu Lys 
        755                 760                 765             


Glu Arg Tyr Ala Glu Leu Glu Lys Leu Asp Gly Ile Pro Lys Asn Tyr 
    770                 775                 780                 


Glu His Glu Phe Gly His His Lys Lys Phe Asn Ile Asn Arg Lys Glu 
785                 790                 795                 800 


Phe Asn Leu Phe Ser Lys Trp Leu Phe Ala Met Asp Glu Val Pro Glu 
                805                 810                 815     


Tyr Lys Asn Ser Leu Lys Glu Leu Leu Asp Asp Lys Asn Phe Phe Val 
            820                 825                 830         


Asn Ser Glu Phe Gln Lys Leu Phe Glu Ser Ser Ser Asn Ile Asn Gln 
        835                 840                 845             


Phe Tyr Glu Ser Thr Lys Ser Lys Phe Lys Asn Trp Leu Asn Asp Gln 
    850                 855                 860                 


Gln Val Gln Asn Ile Arg Lys Thr Ile Gln Pro Glu Asn Tyr Tyr Lys 
865                 870                 875                 880 


Met Met Glu Val Gly Asn Phe His Ile Asn Leu Ser His Phe Ile Ala 
                885                 890                 895     


Phe Gly Val Ser His Asp Phe Ile Glu Lys Ser Gly Lys Asn Ile Leu 
            900                 905                 910         


Arg Pro Ile Thr Ser His Ala Lys Tyr Leu Asn Thr Lys Ile Tyr Asp 
        915                 920                 925             


Ile Asp Leu Glu His Ser Asp Ala Ser Asn Leu Glu Lys Asn Ile Phe 
    930                 935                 940                 


Arg Lys Leu Tyr Lys Ile Arg Leu Glu Asp Cys Leu Leu Tyr Glu Ile 
945                 950                 955                 960 


Ala Leu Arg Tyr Phe Gln Pro Asn Leu Asn Leu Arg Gln Lys Ser Tyr 
                965                 970                 975     


Glu Gln Leu Asn Lys Leu Leu Val Gln Lys Ile Ser Ile Ala Ile Lys 
            980                 985                 990         


Ala Asn Asn Ser Gln Thr Tyr Gln  Val Leu Val Pro Phe  Lys Asp Leu 
        995                 1000                 1005             


Glu Lys  Phe Ala Gln Leu Lys  Ala Ile Asp Asp Asn  Thr Gln Asn 
    1010                 1015                 1020             


Lys Phe  Ser Leu Leu Arg Arg  Leu Pro Glu Tyr Leu  Ser Gln Val 
    1025                 1030                 1035             


Asn Glu  Arg Asn Glu Asn Val  Ser Gly Leu Lys Asp  Met Val Glu 
    1040                 1045                 1050             


Ala Phe  Gly Val Asp Lys Ser  Ile Ser Leu Ala Asp  Met Ser Met 
    1055                 1060                 1065             


Leu Tyr  Asn His Leu Ile Thr  Gln Gln Gly Arg Tyr  Thr Asn Cys 
    1070                 1075                 1080             


Ile Met  Ala Leu Glu Glu Tyr  Phe Ile Trp Lys Glu  Lys Phe Thr 
    1085                 1090                 1095             


Ile Glu  Lys Gln Glu Ser Lys  Lys Phe Lys Asn Arg  Ile Val Val 
    1100                 1105                 1110             


Thr Glu  Ile Pro Val Leu Lys  Asp Tyr Phe Lys Arg  Asp Glu Gln 
    1115                 1120                 1125             


Arg Asn  Asn Ala Phe His Met  Asp Leu Pro Ile Asn  Glu Thr Tyr 
    1130                 1135                 1140             


Lys Ser  Thr Phe Lys Ala Ile  Glu Lys Gln Phe Val  Ala Thr Glu 
    1145                 1150                 1155             


Val Asp  Lys Ala Tyr Thr Lys  Leu Asp Asp Cys Pro  Ser Met Leu 
    1160                 1165                 1170             


Lys Asn  Thr Leu Lys Val Phe  Met Asn Gln Met His  Asp Glu Ile 
    1175                 1180                 1185             


Lys Leu  Gly Tyr Lys Pro Asn  Asp Thr Lys Asp Gly  Ile Lys Gln 
    1190                 1195                 1200             


Lys Arg  Thr Val Ala Glu Asn  Thr Phe Phe Lys Gln  Leu Leu Lys 
    1205                 1210                 1215             


Gly Tyr  
    1220 


<210>  1569
<211>  1146
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1569

Met Glu Ile Lys Glu Lys Thr Glu Lys Arg Phe Leu Ala Val Phe Leu 
1               5                   10                  15      


Asn Lys Gly Asn Met Gly Pro Ile Ala Glu Lys Ala Val Lys Asn Phe 
            20                  25                  30          


Asp Thr Ile Asn Gln His Asp Val Ser Leu Lys Glu Arg Ile His His 
        35                  40                  45              


Phe Ala Ile Gly His Ala Phe Arg Asn Val Asp Lys Ala Ile Phe Glu 
    50                  55                  60                  


Tyr Glu Leu Val Glu Ser Lys Glu Lys Leu Leu Pro Ser Arg Phe Ile 
65                  70                  75                  80  


Asn Leu Gln Leu Asp Arg Phe Pro Ser Thr Lys Arg Leu Phe Asp Val 
                85                  90                  95      


Ile Lys Asn Ile Arg Asn Cys Asn Gly His Tyr Val His Ala Phe Asp 
            100                 105                 110         


Lys Leu Ser Ile Asn Glu Met Asp Lys Arg Glu Asn Asn Ser Asp Thr 
        115                 120                 125             


Asn Arg Val Glu Ala Lys Ile Ile Asp Phe Leu Lys Glu Ala Phe Glu 
    130                 135                 140                 


Phe Ser Val Met Ile His Tyr Leu Lys Glu Asn Glu Leu His Tyr Glu 
145                 150                 155                 160 


Asp Phe Lys Ala Thr Thr Asp Lys Asp Thr Lys Leu Val Thr Tyr Leu 
                165                 170                 175     


Cys Asn Lys Phe Phe Pro Asn Ile Val His Gln Glu Asp Val Arg Glu 
            180                 185                 190         


Ser Phe Ile Lys Leu Asn Phe Lys Glu Ala Leu Asp Glu Leu Leu Phe 
        195                 200                 205             


Ile Glu Val Asp Glu Asp Phe Glu Trp Lys Ile Asp Gly Val His Lys 
    210                 215                 220                 


Val Phe Asp Ile Lys Gln Gly Lys Tyr Leu Ser Phe Val Gly Gln Leu 
225                 230                 235                 240 


Phe Leu Leu Ser Leu Phe Leu Tyr Lys His Glu Ala Asn Gln Leu Ile 
                245                 250                 255     


Ser Lys Ile Lys Gly Phe Lys Arg Asn Asp Asp Glu His His Tyr Lys 
            260                 265                 270         


Arg Asp Ile Phe Thr Phe Phe Ser Lys Lys Val Ser Ser Gln Asp Ile 
        275                 280                 285             


His Ser Glu Glu Lys His Leu Ile Gln Phe Arg Asp Ile Ile Gln Tyr 
    290                 295                 300                 


Leu Asn His Phe Pro Thr Glu Trp Asn Glu Tyr Leu Ser Pro Lys Arg 
305                 310                 315                 320 


Leu Asn Leu Ser Met Thr Asp Gln Leu Glu Lys Tyr Ile Ile Glu Thr 
                325                 330                 335     


Glu Ile Phe Ser Val Phe Pro Lys Tyr Lys Asn Cys Lys Arg Glu Leu 
            340                 345                 350         


Phe Leu Lys Tyr Ala Ile Ser Arg Leu Phe Pro Asp Lys Leu Asp Leu 
        355                 360                 365             


Phe Asp Ala His Ser Leu Thr Met Asp Asp Lys Leu Lys Lys Asp Phe 
    370                 375                 380                 


Asp Tyr Glu Ile Asp Ala Ser Pro Glu Leu Lys Asn Val Asp Leu Lys 
385                 390                 395                 400 


Leu Thr Ile Arg Leu Lys Pro His Asp Phe Asn Lys Gln Ile Lys Arg 
                405                 410                 415     


Lys Arg Lys Leu Glu Lys Glu Val Asn Pro Asn Lys Leu Lys Leu Gln 
            420                 425                 430         


Lys Lys Val Gln Glu Asp Lys Leu Leu Val Met Tyr Gly Arg Asn Gln 
        435                 440                 445             


Asp Arg Phe Met Glu Phe Ala Val Arg Phe Leu Ala Glu Glu Ser Tyr 
    450                 455                 460                 


Phe Gly Lys Asp Ala Glu Phe Lys Met Tyr Arg Phe Tyr Ser Ser Asp 
465                 470                 475                 480 


Glu Gln Asn Asp Phe Leu Arg Lys Gln Lys Glu Glu Ser Ser Lys Lys 
                485                 490                 495     


Glu Ile Asp Gly Asn Lys Tyr His Gln Gly Arg Leu Thr His Tyr Ile 
            500                 505                 510         


Thr Tyr Ser Glu His Lys Glu Arg Tyr Pro Ser Trp Asp Asn Ser Phe 
        515                 520                 525             


Val Phe Gln Asn Asn Ala Phe Gln Leu Ile Leu Ser Leu Ser Asn Gly 
    530                 535                 540                 


Glu Lys Arg Lys Phe Ser Ile Gln Arg Lys Leu Leu Ile Tyr Leu Leu 
545                 550                 555                 560 


Glu Asp Ala Leu Tyr Gly Ser Ser Gly Ser Ile Glu Gly Lys Gly Lys 
                565                 570                 575     


Gln Leu Val Glu Asp Tyr Phe Leu Asn Tyr Leu Met Pro Asp Phe Glu 
            580                 585                 590         


Glu Ala Lys Asn Thr Tyr Ser Gly Glu Thr Leu Asn Ala Lys His Arg 
        595                 600                 605             


Gln Leu Leu Pro Lys Arg Leu Leu Tyr Thr Tyr His Pro Pro Val Gln 
    610                 615                 620                 


Asn Asn Gly Val Gly Asn Ser His Pro Phe Glu Lys Ile Leu Asn Glu 
625                 630                 635                 640 


Thr Glu Gln Gln Glu Lys Arg Tyr Leu Ala Leu Gln Gln Lys Ala Lys 
                645                 650                 655     


Ser Leu Gly Ile Glu Glu Glu Phe Leu Lys Arg Asn Lys Gly Lys Gln 
            660                 665                 670         


Phe Lys Leu Arg Phe Ile Arg Lys Ala Trp His Leu Met Tyr Phe Lys 
        675                 680                 685             


Glu Ser Tyr Gln Lys Gln Ala Glu Val Leu Gly His His Lys Gly Phe 
    690                 695                 700                 


His Ile Thr Lys Asp Glu Phe Asp Asp Phe Ser Lys Trp Met Phe Ala 
705                 710                 715                 720 


Phe Asp Glu Val Pro Gln Tyr Lys Val Tyr Leu Lys Arg Leu Leu Glu 
                725                 730                 735     


Ser Lys Gln Phe Leu Asp Asn Ser Glu Phe Ala His Leu Phe Asp Gln 
            740                 745                 750         


Gly Arg Ser Leu Asn Asp Phe Tyr Val Thr Thr Lys Lys Glu Phe Glu 
        755                 760                 765             


Arg Arg Leu Lys Glu Asn Leu Phe Gln Leu Asp Lys Asn Thr Glu Ser 
    770                 775                 780                 


Gly Gln Tyr Asp Glu Ile Leu Ser Lys Lys Leu Val Tyr Ile Asn Val 
785                 790                 795                 800 


Ser His Phe Ile Asn Tyr Leu Lys Phe Lys Asp Lys Ile Lys Glu Gln 
                805                 810                 815     


Asn Gly Val Ile Arg Tyr Ala Ala Leu Asp Asn Ile Lys Tyr Leu Ile 
            820                 825                 830         


Lys Glu Tyr Tyr Tyr Ala Asp Val Leu Pro Lys Glu Gln Tyr Lys Glu 
        835                 840                 845             


Asn Gly Lys Leu Phe Asn Lys Leu Arg Thr Ala Lys Leu Glu Asp Ala 
    850                 855                 860                 


Leu Leu Tyr Glu Leu Ala Met Lys Tyr Leu Lys Thr Asp Lys His Ile 
865                 870                 875                 880 


Val Gln Lys Val Arg Thr Asn Val Val Asp Ile Leu Thr Ser Lys Val 
                885                 890                 895     


Ile Phe Asp Ile Lys Asp Ala Trp Gly Asn His Leu Tyr Asn Leu Val 
            900                 905                 910         


Val Pro Phe Ser Lys Leu Glu Thr Leu Ala Val Leu Leu Arg Tyr Lys 
        915                 920                 925             


Thr Ser Gln Glu Glu Ile Asp Asp Asn Asn Arg Thr Ser Tyr Leu Gly 
    930                 935                 940                 


Asn Ile Tyr Gln Leu Leu Thr Phe Leu Lys Asp Lys Ile Asn Asn Cys 
945                 950                 955                 960 


Lys Asp Asp Asp Lys Lys Lys Ser Asn Lys Tyr Gly Asp Ile Leu Arg 
                965                 970                 975     


Ile Val Glu Cys Phe Asn Lys His Asn Val Gln Arg Lys Leu Thr Phe 
            980                 985                 990         


Glu Asp Leu Asn Ser Ile Asn Asn  Tyr Ile Ile Ser Gly  Ala Val Glu 
        995                 1000                 1005             


Phe Ser  Lys Ile His Met Glu  Leu Glu Lys Tyr Phe  Ile Leu Lys 
    1010                 1015                 1020             


Tyr Lys  Ile Glu Ser Pro Lys  Phe Ile Asp Ile Lys  Lys Ile Lys 
    1025                 1030                 1035             


Asn Glu  Lys Gly Val Gln Ile  Phe Glu Ile Tyr Tyr  Glu Ser Ile 
    1040                 1045                 1050             


Pro Glu  Ile Arg Arg Lys Ala  Tyr His Phe Gly Val  Pro Glu Arg 
    1055                 1060                 1065             


Phe Ile  Tyr Glu Gln Glu Asn  Lys Lys Thr Glu Ala  Lys Phe Ile 
    1070                 1075                 1080             


Gln Glu  Glu Val Lys Pro Gln  Gly Val Leu Glu Phe  Lys Asp Leu 
    1085                 1090                 1095             


Ser Arg  Glu Thr Lys Thr Val  Cys Arg Val Phe Met  Asn Ile Leu 
    1100                 1105                 1110             


His Ala  Asn Leu Phe Val Arg  Asp Lys Asn Lys Ser  Asp Glu Glu 
    1115                 1120                 1125             


Lys Lys  Asn Asp Phe Glu Lys  Arg Tyr Phe Lys Glu  Val Ile Gln 
    1130                 1135                 1140             


Asn Val  Lys 
    1145     


<210>  1570
<211>  1133
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1570

Met Lys Glu Asn Asn Thr Glu Gln Arg Ile His Tyr Thr Leu Glu Ala 
1               5                   10                  15      


Thr Pro Trp Tyr Phe Gly Ala Tyr Leu Asn Ile Ala Arg His Asn Ile 
            20                  25                  30          


Tyr Leu Ile Ser Asn Glu Ile Gly Arg Lys Leu Lys Pro Glu Arg Lys 
        35                  40                  45              


Leu Cys Lys Glu Glu Gln Ile Ala Asp Ser Phe Leu Val Lys Lys Asp 
    50                  55                  60                  


Phe Ile Glu Lys Gln Asn Val Asn Leu Ile Tyr Val Asn Leu Val Arg 
65                  70                  75                  80  


Phe Leu Pro Leu Ala Lys Met Phe Ser Thr Asp Ile Leu Asp Asp Gln 
                85                  90                  95      


Leu Pro Glu Lys Glu Leu Asn Ile Ser Glu Trp Thr Ser Ile Leu Lys 
            100                 105                 110         


Val Leu Phe Ser Glu Ile Asn Ser Phe Arg Asn Asn Tyr Ser His Tyr 
        115                 120                 125             


Tyr Ser Ser Glu Thr Leu Ser Glu Arg Lys Val Lys Val His Thr Asp 
    130                 135                 140                 


Phe Ala Asp His Ile Lys Asp Ile Phe Ser Leu Ala Val Leu Ser Ala 
145                 150                 155                 160 


Glu Gln Arg Phe Arg Gly Val Leu Pro Gly Ser Ser Phe Arg Phe Val 
                165                 170                 175     


Glu Lys Glu Ile Leu Pro Gln Leu Phe Asn Asp Arg Cys Glu Ile Ser 
            180                 185                 190         


Ala Arg Gly Leu Ile Phe Phe Ile Ser Leu Phe Leu Asp Lys Glu Asn 
        195                 200                 205             


Ala Phe His Leu Phe Asn Lys Val Ser Gly Phe Lys Asn Thr Thr Thr 
    210                 215                 220                 


Phe Asp Phe Leu Ala Thr Arg Glu Val Phe Ser Val Leu Cys Ile Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Ile Ser Glu Asn Pro Asp Gln Ala Gln Gln 
                245                 250                 255     


Leu Asp Ile Leu Asn Tyr Leu Asn Arg Ala Pro Lys Glu Leu Phe Gln 
            260                 265                 270         


Ala Leu Ser Glu Glu Gly Arg Lys Gln Phe Leu Pro Asp Leu Ser Glu 
        275                 280                 285             


Leu Val Lys Ser Ser Ile Ile Glu Asn Ser Met Ser Asp Asp Val Glu 
    290                 295                 300                 


Glu Tyr Arg Tyr Glu Glu Tyr Ile Gln Ala Ile Ser Ser Lys Lys Arg 
305                 310                 315                 320 


Ser Lys Asp Arg Phe Pro Glu Phe Ala Leu Lys Tyr Leu Asp Gln Ser 
                325                 330                 335     


Asp Ser Phe Lys Phe Ser Phe His Ile Leu Leu Gly Lys Ser Lys Ile 
            340                 345                 350         


Arg Gly Tyr Lys Lys Pro Leu Leu Gly Ala Leu Pro Glu Glu Asn Asn 
        355                 360                 365             


Arg Ser Ile Ile Arg Asp Met Thr Thr Phe Gly Gln Leu Lys Thr Tyr 
    370                 375                 380                 


Leu Gly Glu Asp Ala Arg Asp Arg Ile Val Leu Glu Arg Met Phe Cys 
385                 390                 395                 400 


Glu Leu Phe Lys Gly Asp Asp Ile Glu Tyr Phe Thr Gln Tyr Ala Pro 
                405                 410                 415     


Phe Tyr His Ile Ala Asn Asn Lys Ile Gly Ile Leu Ser His Lys Asn 
            420                 425                 430         


Arg Lys Tyr Ser Ser Met Leu Tyr Arg Pro Leu Gln Ala Asp Ala Phe 
        435                 440                 445             


Leu Ser Ile His Glu Leu Pro Lys Val Ala Leu Leu Glu Val Leu Asp 
    450                 455                 460                 


Lys Gly Ser Ala Ser Ala Ile Ile Asp Ala Phe Leu Glu Lys Asn Ile 
465                 470                 475                 480 


Arg His Ile Leu Asn Glu Thr Phe Ile Arg Asp Ile Lys Arg Gln Leu 
                485                 490                 495     


Ser Phe Asp Gly Ala Leu Tyr Arg Phe Cys Phe Asp Glu Lys Leu Ser 
            500                 505                 510         


Val Val Gln Pro Ala Asp Leu Asp Ala Glu Ile Glu Glu Val Glu Met 
        515                 520                 525             


Arg Leu Ala Val Thr Arg Asp Ala Asn Glu Leu Lys Lys Leu Asn Val 
    530                 535                 540                 


Lys Arg Arg Ser Leu Arg Tyr Ala Lys Tyr Val Arg Glu Val Asn Lys 
545                 550                 555                 560 


Arg Lys Lys Val Val Asn Gln Leu Leu Ala Glu Tyr Asp Leu Asn Val 
                565                 570                 575     


Arg Gln Ile Pro Ala Arg Ile Leu Asp Tyr Trp Leu Asp Ile Arg Ile 
            580                 585                 590         


Val Arg Lys Glu Thr Thr Phe Gln Asn Arg Ile Lys Ala Glu Arg Lys 
        595                 600                 605             


Val Cys Lys Lys Arg Leu Lys Asp Leu Gly Lys Gly Lys Gly Pro Arg 
    610                 615                 620                 


Ile Gly Glu Met Ala Ser Tyr Leu Ala Arg Asp Ile Val Asp Leu Val 
625                 630                 635                 640 


Leu Asp Arg Gly Ile Lys Asp Lys Ile Thr Ser Phe Tyr Tyr Asp Ile 
                645                 650                 655     


Leu Gln Ser Ser Leu Ala Leu Tyr Ala Asp Pro Asp Lys Lys Arg Leu 
            660                 665                 670         


Phe Leu Asp Val Cys Ser Arg Glu Leu Gly Leu Phe Asp Lys Lys Lys 
        675                 680                 685             


Gly His Pro Phe Leu Gly Asn Ile Asn Phe Asp Arg Ile Arg Lys Ile 
    690                 695                 700                 


Lys Asp Leu Tyr Lys Ile Tyr Leu Glu Phe Lys Gly Val Lys Glu Arg 
705                 710                 715                 720 


Thr His Gly Ser Asn Lys Tyr Gly Lys His Arg Thr Lys Ala Ile Gln 
                725                 730                 735     


Asp Asn Trp Leu Tyr Asn Thr Phe Tyr Thr Ile Gln Glu Asn Lys Lys 
            740                 745                 750         


Thr Gly Lys Asp Glu Thr Val Ile Lys Leu Pro Glu Asp Ser Ser Leu 
        755                 760                 765             


Val Pro Val Thr Tyr Leu Arg Phe Asn Glu Asp Arg Ser Asp Leu Asp 
    770                 775                 780                 


Thr Trp Leu Ser Thr Val Val Gln Gly Ser Glu His Asn Pro Asn Pro 
785                 790                 795                 800 


Lys Ala Val Asp Leu Pro Thr Asn Leu Phe Asp Glu Gln Leu Val Met 
                805                 810                 815     


Leu Leu Lys Glu Lys Val Gly Ile Lys Glu Asp Ser Gly Lys Lys Tyr 
            820                 825                 830         


Asn Phe Ser Lys Leu Leu Ser Leu Leu Arg Asn Asp Thr Gln Pro Phe 
        835                 840                 845             


Tyr Asn Asp Lys Arg Glu Tyr Ile Leu Phe Lys Asp Thr Pro Tyr Glu 
    850                 855                 860                 


Val Arg Val Ala Phe Asp Pro Leu Ser Ser Arg Lys Phe Ser Glu His 
865                 870                 875                 880 


Tyr Gln Glu Ala Met Asn Gln Ser Phe Arg Ile Arg Lys Lys Met Asp 
                885                 890                 895     


Lys Arg Ile Gln Leu Asn Gln Val Arg Arg Leu Phe Lys Lys Ala Ile 
            900                 905                 910         


Asp Glu Asn Glu Lys Gln Ile Arg Phe Tyr Gln Ala Lys Asp Arg Ile 
        915                 920                 925             


Ile Leu Leu Met Leu Lys Asp Met Ile Gly Arg Asp Leu Asp Phe Ser 
    930                 935                 940                 


Leu Asn Ala Val Ser Pro Gln Ala Pro Gln Asn Pro Leu Asn Thr Pro 
945                 950                 955                 960 


Val Asp Leu Ser Glu Ile Ile His Ser Lys Thr Ile Thr His Thr Cys 
                965                 970                 975     


Lys Arg Lys Asp Phe Ser Ile Phe Arg Lys Leu Leu Ser Asp Arg Arg 
            980                 985                 990         


Leu Ser Gly Leu Phe Gln Tyr Phe  Asp Ser Asp Ile Ile  Pro Tyr Glu 
        995                 1000                 1005             


Ile Leu  Arg Lys Glu Leu Ser  Asp Tyr Glu Arg Tyr  Lys Glu Gln 
    1010                 1015                 1020             


Val Phe  Lys Thr Val Phe Glu  Leu Glu Lys Gln Ile  Ile Ala Val 
    1025                 1030                 1035             


Met Ser  Glu Glu Glu Leu Asn  Asn Leu Lys Ala Thr  Ser Gly Thr 
    1040                 1045                 1050             


Asn Ile  Gln His Lys Pro Tyr  Leu Asp Trp Leu Ala  Asp Tyr Gly 
    1055                 1060                 1065             


Ile Leu  Thr Arg Glu Glu Arg  Ala Phe Cys Ile Glu  Val Arg Asn 
    1070                 1075                 1080             


Lys Leu  Ser His Asn Gln Phe  Pro Asp Lys Ala Val  Met Asp Thr 
    1085                 1090                 1095             


Phe Val  Gly Gln Pro Asp Ser  Thr Gln Thr Asn Ile  Lys Gln Ile 
    1100                 1105                 1110             


Val Ser  Ala Tyr Ile Thr Ile  Val Asn Thr Leu Ile  Ala Thr Lys 
    1115                 1120                 1125             


Leu Leu  Ala Lys Arg 
    1130             


<210>  1571
<211>  1057
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1571

Met Thr Ile Lys Glu Gln Ser His Phe Ala Ala Tyr Tyr Asn Met Ala 
1               5                   10                  15      


Arg His Asn Met Tyr Glu Thr Leu Cys Tyr Ile Ser Lys Ile Ser Gly 
            20                  25                  30          


Ile Gln Glu Gly Glu Asp Asn Lys Glu Ser Lys Ile Glu Asp Met Gln 
        35                  40                  45              


Leu Leu Arg Val Leu Thr Thr Lys Gly His Pro Glu Glu Lys Ile Arg 
    50                  55                  60                  


Ile Glu Lys Leu Ile Tyr Lys His Leu Pro Leu Phe Arg Pro Ala Val 
65                  70                  75                  80  


Glu Asp Leu Arg Lys Lys Ser Lys Glu Asn Val Lys Ser Pro Glu Leu 
                85                  90                  95      


Leu Ala Lys Val Ile Lys Asn Trp Ala Lys Val Ile Thr Tyr Tyr Arg 
            100                 105                 110         


Asp Lys Phe Thr His Tyr Val Phe Ile Asp Lys Arg His Glu Asn Lys 
        115                 120                 125             


Glu Phe Leu Asn Ala Glu Met Ser Val Ala Asn Asp Leu Asn Gln Ile 
    130                 135                 140                 


Phe Thr Ala Ser Ala Arg Val Ile Lys Glu Arg Phe Gly Leu Ser Thr 
145                 150                 155                 160 


Glu Leu Glu Phe Leu Thr Lys Gly Arg Tyr Arg Thr Gln Thr Ile Asp 
                165                 170                 175     


Gly Lys Arg Ser Thr Lys Leu Asn Pro Asn Phe Ile Tyr Ser Leu Gln 
            180                 185                 190         


Asp Lys Asn Glu Arg Leu Asn Lys Met Gly Leu Ile Phe Leu Ala Cys 
        195                 200                 205             


Gln Leu Ile Glu Lys Lys Tyr Ala Ser Met Leu Phe Asp Gln Gln Gly 
    210                 215                 220                 


Tyr Met Gly Arg Asp Ile Tyr Phe Asp Phe Thr Pro Ala Gln Cys Lys 
225                 230                 235                 240 


Tyr Ile Arg Glu Val Phe Ser Ala His Arg Ile Val Leu Pro Arg Gly 
                245                 250                 255     


Arg Met Asp Val Glu Arg Asn Glu Ile Thr Ile Ala Met Asp Met Phe 
            260                 265                 270         


Asn Glu Leu Gly Lys Cys Pro Lys Glu Leu Phe Glu Ile Ile Ser Lys 
        275                 280                 285             


Glu Glu Gln Lys Arg Phe Arg Thr Lys Ser Glu Thr Thr Gly Glu Glu 
    290                 295                 300                 


Val Leu Leu Met Arg His Ser Asp Arg Phe Ala Thr Leu Ala Leu Gln 
305                 310                 315                 320 


Tyr Ile Asp Asn Arg Lys Val Phe Glu Lys Ile Arg Phe Gln Leu Ser 
                325                 330                 335     


Leu Gly Lys Tyr Arg Tyr Lys Phe Tyr Asp Lys Thr Cys Val Asp Gly 
            340                 345                 350         


Asp Thr His Val Arg Ile Leu Gln Lys Glu Leu Asn Gly Phe Gly Arg 
        355                 360                 365             


Ile Asn Glu Ile Glu Leu Leu Lys Glu Glu Lys Trp Gly Gly Leu Ile 
    370                 375                 380                 


Arg Lys Phe Glu Asp Ala Lys Ile Asp Thr Ala Glu Thr Lys Pro Tyr 
385                 390                 395                 400 


Ile Thr Asp Gln Tyr Pro Gln Tyr Leu Phe Asn Gly Asn Arg Ile Gly 
                405                 410                 415     


Ile Tyr Phe Asn Ser Ala His Gly Lys Ala Met Arg Asn Gly Ala Tyr 
            420                 425                 430         


Ile Pro Asp Ile Glu Ser Gly Ala His Cys Ile Gln Pro Ile Cys Trp 
        435                 440                 445             


Ile Ser Asn Tyr Glu Leu Pro Ala Leu Ile Phe His His Ile Leu Thr 
    450                 455                 460                 


Lys Asp Glu Lys Lys Ser Leu Thr Glu Lys Ile Ile Ile Asp Cys Val 
465                 470                 475                 480 


Glu Arg Tyr Lys Lys Leu Phe Asn Asp Ile Ala Glu Gly Lys Val Ala 
                485                 490                 495     


Arg Thr Gly Asn Ala Thr Ser Asp Phe Glu Met Ile Ser Lys Glu Tyr 
            500                 505                 510         


Gly Ile Glu Lys Ser Asp Ile Pro Arg Glu Leu Gln Asp Tyr Phe Asn 
        515                 520                 525             


Gly Thr Glu Arg Asp Gly Ile Glu Gln Tyr Ala Lys Ala Gln Ile Arg 
    530                 535                 540                 


Glu Met Ile Glu Glu Asn Arg Ile Arg Leu Glu Gln Phe Asn Ser Lys 
545                 550                 555                 560 


Leu Lys Lys Ile Glu Asp Gly Glu Val Lys Tyr Gly Lys Arg Asp Tyr 
                565                 570                 575     


Thr Glu Ile Arg Thr Gly Glu Leu Ala Gln Tyr Leu Ala Lys Asp Ile 
            580                 585                 590         


Val Met Phe Met Pro Lys Ala Lys Tyr Lys Pro Thr Ser Lys Asn Tyr 
        595                 600                 605             


Asn Val Met Gln Ala Leu Leu Ala Thr Phe Asn Gly Ser Glu Ser Gly 
    610                 615                 620                 


Ser Thr Leu Asp Glu Val Asp Asp Met Phe Asp Asn Ile Lys Ala Cys 
625                 630                 635                 640 


Tyr Trp Lys Asn Glu Ser Asp Asn His Pro Phe Leu Glu Tyr Val Leu 
                645                 650                 655     


Gly Glu Glu Pro Lys Asp Ile Ile Ala Phe Tyr Lys Ile Tyr Leu Glu 
            660                 665                 670         


Leu Arg Gly Glu Tyr Leu Asp Lys Cys Ile Lys Lys Met Asp Leu Ala 
        675                 680                 685             


Thr Ile Pro Phe Ile His Thr Glu Arg Lys Arg Trp Glu Lys Arg Asp 
    690                 695                 700                 


Glu Lys Phe Phe Lys Glu Leu Ala Gln Arg Tyr Ala Thr Gln Pro Ile 
705                 710                 715                 720 


Glu Leu Pro Arg Gly Leu Tyr Asp Arg Ala Ile Lys Glu Tyr Leu Lys 
                725                 730                 735     


Ser Lys Ser Ile Leu Glu Asp Val Ile Ala Gln Glu Gln Cys Asn Val 
            740                 745                 750         


Thr Tyr Leu Ile Ala Arg Tyr Met Gln Asp Val Leu Lys Asp Asp Ser 
        755                 760                 765             


Gln Gln Phe Tyr Ser Leu Pro Arg His Tyr Ser Cys Leu Ser Glu Lys 
    770                 775                 780                 


Asp Lys Tyr Leu Ser Leu Thr Glu Arg Glu Ala Ile Ala Lys Ser Asp 
785                 790                 795                 800 


Ala Leu Asn Ser Phe Lys Lys Arg Glu Arg Glu Lys Glu Asn Glu Asn 
                805                 810                 815     


Arg Arg Gly Asn Arg Arg Tyr Asn Lys Gly Glu Asn Lys Asn Thr Ile 
            820                 825                 830         


Lys Asp Arg Asp Thr Glu Glu Lys Phe Asn Ser Leu Tyr Arg Lys Met 
        835                 840                 845             


Asp Asn Asn Glu Arg Ile Leu Arg Arg Tyr Lys Val Gln Asp Met Leu 
    850                 855                 860                 


Leu Tyr Leu Leu Ala Cys Asp Ile Ile Lys Gly Ile Met Arg Glu Asp 
865                 870                 875                 880 


Phe Gly Tyr Lys Leu Ser Met Ile Thr Asp Gly Lys Asn Ser Asn Phe 
                885                 890                 895     


Phe Asp Tyr Lys Met Pro Glu Phe Lys Thr Thr Ile Thr Leu Lys Glu 
            900                 905                 910         


Gly Lys Lys Phe Thr Ile Lys Gln Gln Tyr Leu Lys Ile Lys Asn Tyr 
        915                 920                 925             


Gly Asp Phe Leu Lys Phe Ile Phe Asp Leu Arg Ile Asp Ser Leu Leu 
    930                 935                 940                 


Ser Asn Gly Thr Lys Val Glu Ile Asp Arg Asn Ile Leu Glu Asp Glu 
945                 950                 955                 960 


Leu Ser Asn Tyr Asp Gly Ser Arg Pro Lys Val Phe Glu Thr Leu Leu 
                965                 970                 975     


Met Ile Glu Lys Ile Val Val Glu Lys His Lys Glu Leu Lys Asp Leu 
            980                 985                 990         


Glu His Ile Thr Phe Gly Asp Val  Leu Asn Val Ile Lys  Met Glu Glu 
        995                 1000                 1005             


Gly Glu  Lys Lys Ile Leu Arg  Leu Ile Arg Asn Ala  Phe Ser His 
    1010                 1015                 1020             


Asn Tyr  Tyr Pro Thr Ile Lys  Asp Val Asn Tyr Asp  Asn Met Pro 
    1025                 1030                 1035             


Glu Val  Ala Glu Ser Leu Lys  Asp Ile Leu Glu Lys  Glu Ser Lys 
    1040                 1045                 1050             


Lys Leu  Thr Asn 
    1055         


<210>  1572
<211>  1081
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1572

Met Gln Ala Gln Ser Leu Phe Asp Glu Tyr Lys His Leu Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Val Met Ser Ile Met Asn Ile Ile Thr Val Leu Asn His Ile 
            20                  25                  30          


His Gln Ile Ala Gly Leu Lys Arg Asn Glu Leu Gly Asp Asp Asp Asn 
        35                  40                  45              


Ile Tyr Ser His Pro Val Leu Lys Tyr Ile Ala Pro Glu Asn Asn Ser 
    50                  55                  60                  


Thr Thr Leu Pro Glu Lys Arg Asp Leu Ile Lys Glu Leu Leu Leu Glu 
65                  70                  75                  80  


Tyr Leu Pro Phe Leu Glu Ala Met Lys Asp Cys Tyr Lys Glu Val Lys 
                85                  90                  95      


Val Glu Lys Asp Lys Arg Asn Asn Lys Tyr Val Lys Asp Lys Lys Gln 
            100                 105                 110         


Val Phe Ile Arg Asn Tyr Ser Asp Ile Tyr Cys Ile Tyr Trp Thr Leu 
        115                 120                 125             


Tyr Asn Ile Phe Ser Thr Leu Ile Asn Tyr Arg Asp Lys Ser Cys His 
    130                 135                 140                 


Tyr Arg Phe Ile Pro Ser Lys Asp Gln Glu Glu Tyr Ser Lys Arg Thr 
145                 150                 155                 160 


Glu Tyr Asp Thr Val Arg Ile Ile Asn Lys Tyr Tyr Thr Tyr Ala Leu 
                165                 170                 175     


Arg Lys Thr Lys Glu Lys Tyr Gly Tyr Thr Thr Glu Gln Leu Ser Phe 
            180                 185                 190         


Ile Gln Asn Asn Arg Tyr Thr Asp Asp Lys Lys Val Asn Phe Asn Phe 
        195                 200                 205             


Phe Leu Ser Met Gln Ser Ser Asn Asn Asn Leu Ser His Val Gly Val 
    210                 215                 220                 


Ala Gln Leu Ile Cys Leu Phe Leu Gln Lys Lys Asp Val Asp Asn Phe 
225                 230                 235                 240 


Leu Glu Asn Leu Pro Ile Tyr Asp Asn Arg Tyr Cys Leu Gly Ile Asp 
                245                 250                 255     


Glu His Met Ile Ile Lys Arg Ser Leu Ala Leu His Ser Ile Lys Leu 
            260                 265                 270         


Pro Lys Glu Arg Leu Asn Ser Glu Lys Lys Asp Met Ala Ile Ala Met 
        275                 280                 285             


Asp Met Leu Asn Glu Leu Lys Arg Cys Pro Lys Glu Leu Phe Asn Thr 
    290                 295                 300                 


Leu Pro Phe Asp Lys Gln Glu Arg Phe Arg Ile Ile Ser Ser Asp His 
305                 310                 315                 320 


Lys Glu Val Leu Leu Met Arg Ser Thr Asp Arg Phe Val Pro Leu Ile 
                325                 330                 335     


Leu Gln Tyr Ile Asp Cys Asn Lys Lys Phe Lys Asp Ile Arg Phe His 
            340                 345                 350         


Val Asn Met Gly Lys Leu Arg Tyr Leu Phe Ser Pro Asn Lys Leu Cys 
        355                 360                 365             


Ile Asp Asn Gln Glu Arg Val Arg Met Leu Glu His Leu Leu Asn Gly 
    370                 375                 380                 


Tyr Gly Arg Ile Asp Glu Val Glu Tyr Leu Arg Lys Ala Pro Asn Gly 
385                 390                 395                 400 


Thr Phe Gly Asn Thr Asn Ile Pro Ile Lys Gly Phe Gly Glu Ile Glu 
                405                 410                 415     


Arg Asp Ser Ala Asp Ser Asn Asn Tyr Pro Tyr Ile Val Asp Thr His 
            420                 425                 430         


Thr His Tyr Ile Leu Asn Asn Asn Lys Val Glu Phe Cys Phe Cys Glu 
        435                 440                 445             


Asp Ser Lys Asn Lys Asn Val Phe Pro Thr Ile Glu Lys Glu Ile Asn 
    450                 455                 460                 


Gly Lys Trp Tyr Val Glu Lys Thr Ala Pro His Cys Arg Ile Ser Phe 
465                 470                 475                 480 


Phe Glu Ile Pro Ala Met Ala Phe His Met Phe Leu Cys Gly Ser Glu 
                485                 490                 495     


Lys Thr Glu Lys Leu Ile Lys Asp Val Tyr Asn Asn Tyr Ile Ser Leu 
            500                 505                 510         


Phe Asn Ala Leu Lys Asn Gly Ala Leu Thr Glu Glu Asn Tyr Lys Asp 
        515                 520                 525             


Phe Asn Ile Pro Glu Cys Asp Met Pro Lys Lys Ile Leu Asp Phe Leu 
    530                 535                 540                 


Lys Gly Lys Ala Glu Gly Lys Ser Ile Asp Gly Tyr Val Lys Asn Ile 
545                 550                 555                 560 


Leu Lys Lys Glu Leu Lys Asp Thr Arg Lys Arg Ile Glu Gln Ala Pro 
                565                 570                 575     


Ser Glu Lys Asp Gln Met Pro Ser Lys Arg Asn Lys Ile Gly Thr Lys 
            580                 585                 590         


Ser Tyr Lys Arg Val Leu Thr Gly Lys Leu Ala Asp Phe Leu Ala Lys 
        595                 600                 605             


Asp Ile Val Lys Tyr Gln Pro Thr Leu Cys Ala Gly Asp Asp Tyr Gly 
    610                 615                 620                 


Ile Asp Arg Met Thr Gly Met Asn Tyr Arg Ile Met Gln Ala Thr Ile 
625                 630                 635                 640 


Ala Thr Tyr Asn Asp Asp Asp Asp Phe Asp Thr Phe Tyr Asn Val Phe 
                645                 650                 655     


Lys Met Ala Gly Leu Val Asp Gly Asp Glu Arg Lys Asn His Pro Phe 
            660                 665                 670         


Leu Lys Lys Val Leu Leu Ser Lys Pro Gln Asn Thr Val Ala Phe Asn 
        675                 680                 685             


Ile Lys Tyr Leu Lys Glu Lys Glu Ile Tyr Leu Arg Asn Ile Glu Lys 
    690                 695                 700                 


Lys Asn Ile Ile Pro Pro Phe Val Asn Arg Glu Arg Asn Lys Trp Cys 
705                 710                 715                 720 


Glu Arg Asp Cys Glu Tyr Tyr Arg Ile Leu Gly Glu Asn Leu Leu Asp 
                725                 730                 735     


Leu Pro Ile Glu Leu Pro Arg Gln Met Phe Tyr Lys Asp Ile Arg Ala 
            740                 745                 750         


Gln Leu Glu Pro Leu Met Pro Glu Ile Asp Phe Ser Gln Thr Asn Thr 
        755                 760                 765             


Thr Tyr Leu Ile Ala Glu Tyr Leu Lys Arg Val Arg Gly Asp Asp Phe 
    770                 775                 780                 


Gln Glu Phe Tyr Ser Trp Glu Arg Asn Tyr Arg Tyr Ile Asp Phe Leu 
785                 790                 795                 800 


Lys Cys Ile Arg Asp Asp Asn Gly Arg Ile Cys Ala Gln Tyr Thr Thr 
                805                 810                 815     


Thr Glu Glu Arg Glu Ser Leu Trp Glu Asp Ser Lys Asn Arg Thr Ala 
            820                 825                 830         


Glu Tyr Lys Arg Ser Glu Glu Gln Lys Asn Glu Lys Lys Asp Lys Asn 
        835                 840                 845             


Phe Glu Asp Ser Leu Glu Glu Arg Ile Ser Ser Ser His Ile Lys Phe 
    850                 855                 860                 


Gln Asn Thr Glu Lys His Ile Arg Arg Tyr Lys Val Gln Asp Ala Leu 
865                 870                 875                 880 


Leu Phe Met Ile Ala Glu Lys Gln Phe Gly Lys Tyr Leu Asp Asp Ile 
                885                 890                 895     


Lys Ala Lys Asn Phe Lys Leu Lys Asp Ile Met Pro Asp Thr Asp Lys 
            900                 905                 910         


Gly Ile Leu Ser Glu Thr Met Pro Ile Asp Phe Thr Phe Thr Lys Lys 
        915                 920                 925             


Asn Ile Lys Tyr Asn Ile His Ala Lys Asn Leu Lys Phe Lys Glu Tyr 
    930                 935                 940                 


Gly Asp Leu Phe Ile Leu Ala Asn Asp Lys Arg Leu Glu Ser Leu Trp 
945                 950                 955                 960 


Lys Ile Leu Ala Thr Asp Thr Val Asn Lys Glu Glu Ile Ser Glu Glu 
                965                 970                 975     


Phe Ala Lys Tyr Asp Phe Cys Arg Pro Asp Ile Thr Lys Leu Val Leu 
            980                 985                 990         


Asp Phe Glu Lys Asp Val Leu Glu  Lys Tyr Pro Glu Ile  Ile Glu Glu 
        995                 1000                 1005             


Ala Glu  Lys Glu Tyr Lys Lys  Phe Asp Phe Lys Phe  Ile Leu Asp 
    1010                 1015                 1020             


Trp Leu  Ile Asn Lys Lys Lys  Leu Asn Tyr Gly Ile  Arg Asn Lys 
    1025                 1030                 1035             


Leu Leu  Leu Ile Arg Asn Ala  Phe Asn His Asn Ser  Tyr Pro Asp 
    1040                 1045                 1050             


Lys Lys  Tyr Ala Glu Val Arg  Glu Leu Pro Glu Ile  Ala Thr Asn 
    1055                 1060                 1065             


Leu Lys  Lys Thr Phe Asp Glu  Asn Ala Lys Lys Tyr  Glu 
    1070                 1075                 1080     


<210>  1573
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1573

Met Glu Thr Lys Gln Gln Val Gly Lys Gly Ile Ser Tyr Asp His Arg 
1               5                   10                  15      


Arg Pro Asp Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asp Gly Val Ile Gln Glu Phe Ala Met Arg Leu Asn Arg 
        35                  40                  45              


Glu Tyr Asp Pro Glu Asn Lys Asn Gln Ser Leu Phe Ser Tyr Phe Asn 
    50                  55                  60                  


Ile Asn Ala Ser Phe Thr Asp Trp Glu Arg Gly Val Asn Ile Leu Lys 
65                  70                  75                  80  


Glu Tyr Trp Pro Met Met Glu Phe Ile Asp Arg Pro Ala Thr Asp Lys 
                85                  90                  95      


Gln Phe Glu Ala Glu Lys Pro Glu Asn Arg Glu Ala Ala Lys Arg Lys 
            100                 105                 110         


Tyr Phe Leu Ala Thr Leu Gly Ala Leu Leu Thr Ser Ile Lys Asp Leu 
        115                 120                 125             


Arg His Tyr Tyr Thr His Tyr Tyr His Pro Pro Val His Leu Asn Asp 
    130                 135                 140                 


Asp Leu Phe Leu Phe Leu Asp His Ala Leu Leu Tyr Thr Ala Phe Asp 
145                 150                 155                 160 


Val Lys Lys Thr Lys Met Lys Asp Asp Lys Thr Arg Gln Leu Leu Asn 
                165                 170                 175     


Gln Asn Leu Ser Leu Glu Leu Glu Lys Leu Lys Lys Leu Lys Val Glu 
            180                 185                 190         


Glu Leu Lys Lys Lys Lys Glu Lys Gly Ile Lys Val Asn Leu Gln Asp 
        195                 200                 205             


Glu Lys Gly Ile Leu Asn Ala Ile Tyr Asn Asp Ala Phe Ala His Ile 
    210                 215                 220                 


Ile Thr Lys Glu Lys Asp Ser Asp Lys Asp Lys Leu Glu Thr Arg Tyr 
225                 230                 235                 240 


Lys Ser Ile Leu Pro Gln Asp Glu Ala Ala Glu Thr Gly Ile Asn Ile 
                245                 250                 255     


Ser Ile Ser Gly Leu Ile Phe Leu Leu Ser Leu Phe Leu Ser Arg Lys 
            260                 265                 270         


Glu Ile Glu Gln Leu Lys Ser Asn Ile Glu Gly Tyr Lys Gly Lys Val 
        275                 280                 285             


Leu Asn Ile Glu Thr Glu Val Asp Arg Lys His Asn Ser Leu Lys Tyr 
    290                 295                 300                 


Met Ala Thr His Trp Val Phe Ser Ile Leu Ala Phe Lys Gly Leu Lys 
305                 310                 315                 320 


Gln Arg Leu Thr Asn Ser Phe Glu Lys Glu Ser Leu Leu Ile Gln Met 
                325                 330                 335     


Met Asp Glu Leu Asn Lys Val Pro Asp Glu Leu Tyr Gln Thr Leu Ser 
            340                 345                 350         


Glu Thr Ala Lys Lys Glu Phe Leu Glu Asp Ile Asn Glu Tyr Val Ser 
        355                 360                 365             


Glu Gly Asp Asp Asn Glu Lys Ala Thr Tyr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Ser Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gln Phe Pro Thr Leu Lys Phe Gln Ile Phe Val Gly 
                405                 410                 415     


Gln Tyr Leu His Asp Asn Arg Pro Lys Thr Leu Ala Ser Asn Gly Met 
            420                 425                 430         


Thr Ala Gln Arg Met Ile Lys Glu Lys Ile Asn Leu Phe Gly Asn Leu 
        435                 440                 445             


Ser Glu Val Thr Lys His Lys Ser Asp Phe Phe Glu Lys Glu Ser Ala 
    450                 455                 460                 


Ala Gln Gly Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Trp Ala Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Val Tyr Ile Asp Met Ile Gly Lys Glu Gly Lys Ala 
                485                 490                 495     


Lys Glu Ile Gln Val Gln Ile Asn Lys Tyr Arg Lys Gln Leu Asn Pro 
            500                 505                 510         


Ala Pro Gln Arg Asp Lys Arg Ile Ser Lys Lys Glu Ile Ile Glu Gln 
        515                 520                 525             


Leu Tyr Lys Glu Lys Val Val Tyr Gly Asp Pro Thr Leu Met Leu Ser 
    530                 535                 540                 


Ala Asn Glu Leu Met Ala Leu Leu Tyr Glu Leu Ile Val Asn Gly Lys 
545                 550                 555                 560 


Ser Gly Ala Glu Leu Glu Asn Lys Ile Val Glu Gln Ile Ile Ala Arg 
                565                 570                 575     


Tyr Glu Gln Ile Glu Ala Tyr Asp Pro Thr Thr Gln Gln Leu Pro Thr 
            580                 585                 590         


Asn Gln Met Pro His Lys Leu Gln Lys Ser Arg Lys Asp Ser Lys Val 
        595                 600                 605             


Thr Asp Thr Asp Lys Leu Leu Lys Thr Ile Asp Lys Glu Ile Asp Glu 
    610                 615                 620                 


Gly Asn Lys Lys Leu Glu Leu Ile Ala Cys His Arg Lys Glu Trp Glu 
625                 630                 635                 640 


Glu Ala Glu Gln Arg Lys Lys Ser Gly Lys Arg Asn Asn Pro Gly Thr 
                645                 650                 655     


Lys Ser Arg Lys His Leu Phe Tyr Ala Ser Glu Met Gly Glu Glu Ala 
            660                 665                 670         


Thr Trp Ile Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Pro Ala Arg 
        675                 680                 685             


Ala Glu Trp Lys Gly Thr His His Ser Glu Leu Gln Arg Leu Leu Ala 
    690                 695                 700                 


Phe Tyr Ser Thr Gln Arg Leu Glu Ala Trp Gln Leu Val Glu Ser Val 
705                 710                 715                 720 


Trp Thr Ala Asn Thr His Ser Phe Trp Glu Glu Asn Phe Lys Glu Ala 
                725                 730                 735     


Phe Tyr Lys Pro Glu Phe Glu Asn Phe Tyr Gly Ala Tyr Ile Glu Ile 
            740                 745                 750         


Arg Thr Lys Ile Leu Thr Thr Cys Arg Ser Ile Leu Glu Asn Asn Pro 
        755                 760                 765             


Glu Ala Thr Met Asn Asn Asp Thr Glu Lys Glu Trp Asp Lys Val Phe 
    770                 775                 780                 


Thr Leu Phe Asp Lys Arg Leu Tyr Arg Thr Ser Thr Thr Asp Glu Gln 
785                 790                 795                 800 


Lys Lys Gln Leu Leu Thr Lys Pro Phe Ala Phe Pro Arg Gly Leu Phe 
                805                 810                 815     


Asp Asp Lys Pro Thr Phe Leu Pro Gly Ser Lys Pro Asn Glu Asn Pro 
            820                 825                 830         


Glu Arg Phe Ala Ala Trp Tyr Ser Tyr Gly Tyr Thr Tyr Ser Gly Lys 
        835                 840                 845             


Phe Gln Ser Phe Tyr Asp Met Pro Arg Asn Tyr Ser Asp Trp Tyr Lys 
    850                 855                 860                 


Lys Leu Lys Glu Asp Gly Lys Leu Pro Arg Leu Asp Lys Lys Thr Glu 
865                 870                 875                 880 


Gln Glu Lys Ile Leu Arg Phe Arg Met Asp Cys Asp Leu Asn Ile Lys 
                885                 890                 895     


His Ile Arg Phe Gln Asp Ile Tyr Val Lys Leu Met Val Asp Ser Leu 
            900                 905                 910         


Tyr Lys Ala Val Phe Gly Gln Gln Pro Glu Phe Asp Leu Ser His Leu 
        915                 920                 925             


Tyr Asp Thr Arg Ser Glu Arg Tyr Glu Asn Asn Thr Ile Ala Gln Arg 
    930                 935                 940                 


Gln Lys Ser Arg Gln Glu Gly Asp Asn Ser Asp Asn Ala Ile Asn Glu 
945                 950                 955                 960 


Asn Tyr Val Trp Asn Lys Thr Phe Ala Ile Ser Leu Tyr Asn Gly Arg 
                965                 970                 975     


Ile Thr Glu Ser Gln Val Lys Leu Lys Asp Val Gly Lys Phe Arg Arg 
            980                 985                 990         


Phe Ala Thr Asp Pro Arg Val Gln  Thr Leu Ile Ser Tyr  Asp Asp Thr 
        995                 1000                 1005             


Arg Thr  Trp Thr Lys Leu Glu  Ile Glu Asn Glu Leu  Asp Asn Lys 
    1010                 1015                 1020             


Ala Asp  Ala Tyr Glu Pro Ile  Arg Arg Thr Gln Ser  Leu Lys Ala 
    1025                 1030                 1035             


Ile Gln  Gln Leu Glu Lys Asn  Ile Leu Lys Lys Asn  Gly Phe Asn 
    1040                 1045                 1050             


Gly Lys  Gln His Pro Glu Glu  Leu Lys His Asn Gly  Asn Pro Asn 
    1055                 1060                 1065             


Phe Arg  Lys Tyr Ile Ala Asn  Gly Leu Leu Lys His  Arg Thr Asp 
    1070                 1075                 1080             


Ile Arg  Gln Glu Glu Leu Ala  Leu Ile Ser Asp Thr  Glu Phe Gln 
    1085                 1090                 1095             


Glu Ile  Gly Leu Glu Arg Ile  Arg Gln Thr Asn Pro  Leu Ile Gln 
    1100                 1105                 1110             


Lys Ala  Tyr Leu Leu Ile Leu  Leu Arg Asn Lys Phe  Gly His Asn 
    1115                 1120                 1125             


Gln Leu  Pro Asp Gln Glu His  Phe Arg Leu Met Arg  Ser Ile Tyr 
    1130                 1135                 1140             


Pro Tyr  Asn Gln Gln Glu Ser  Tyr Ser Ala Tyr Phe  Asn His Val 
    1145                 1150                 1155             


Ile Thr  Gln Ile Ile Glu Glu  Leu Asn Thr 
    1160                 1165             


<210>  1574
<211>  1094
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1574

Met Glu Ala Asn Glu Gln Asn Gln Glu Asn Arg Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Asn Asn His Ile Ala Ala Asp Phe Gly Gln Ala Val 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ser Gly Phe Leu Cys Asn Lys Glu 
    50                  55                  60                  


Ile Lys Lys Leu Asn Trp Asn His Ile Tyr Ala Lys Thr Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ile Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Val Asn Ser Asp Lys Glu Gly Lys Asp Phe Ala Ala Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Ser Glu Leu Gln Asp Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Glu Asn Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Ala Glu Leu Thr Asp Met Leu Thr Ile Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Thr Asp Ala Asp Tyr 
                165                 170                 175     


Glu Leu Val Glu Thr Lys Gln Val Val Thr Thr Gly Asn Ile Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Met Phe Leu Glu Arg Glu His 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asn Leu Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Gly 
            260                 265                 270         


Val Ile Thr Asp Glu Glu Lys Met Gln Phe Arg Pro Glu Leu Asp Glu 
        275                 280                 285             


Leu Asp Ile Glu Lys Leu Ile Ala Asn Ser Thr Asn Asp Asp Glu Arg 
    290                 295                 300                 


Glu Arg Ile Leu Asp Glu Ile Gly Tyr Glu Glu Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg Tyr Asn Asn Arg Phe Pro Tyr Phe Ala Met Arg 
                325                 330                 335     


Phe Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Arg Tyr Thr Lys Gln Leu Ala Gly Glu 
        355                 360                 365             


Gln Thr Glu Arg Val Val Gln Glu Asn Val Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asp Pro Glu Leu Ile Gln Gln Lys Ile Asp Asn Gln 
385                 390                 395                 400 


Gln Arg Thr Asp Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Ile Ala Ile Leu Ile 
            420                 425                 430         


Pro Lys Ser Lys Pro Glu Ser Lys Val Gly Asn Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Asp Tyr Leu Gln Lys Gly Lys Ala Glu Glu Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Ile Lys Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Leu Lys Leu Pro Ala Asn Trp Asn Glu Phe Ala Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asp Ala Ala Met Glu Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Asp Val Leu Ile Thr Tyr Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Asp Val Glu Asp Asn Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Leu Glu Lys His Lys Leu 
            580                 585                 590         


Asp Lys Ser Val Lys Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Met Val Ser Lys Glu Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Ala Asp Thr Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Val Leu Glu Gly Asp Gly His Pro Phe Leu Thr Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Glu Leu Tyr Met Asn 
        675                 680                 685             


Ala Lys Val Gln Tyr Leu Ile Gln Phe Tyr Lys Pro Ser Lys Asp Lys 
    690                 695                 700                 


Val Asp Lys Arg Gly Arg Pro Thr Thr Glu Val Lys Leu Pro Pro Leu 
705                 710                 715                 720 


Asp Lys Arg Ser Asn Ile Pro Phe Thr Ile Arg Gln Trp Asp Glu Lys 
                725                 730                 735     


Glu Lys Tyr Asn Leu Asn Ala Trp Leu Arg Asn Val Thr Val Gly Lys 
            740                 745                 750         


Asn Thr Lys Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe 
        755                 760                 765             


Asp Glu Thr Leu Cys Asp Leu Leu Ser Gln Gln Leu Asp Ala Arg Thr 
    770                 775                 780                 


Val Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Leu Trp 
785                 790                 795                 800 


Trp Lys Thr Arg Asp Asp Ala Thr Gln Asp Phe Tyr Gln Ser Glu Arg 
                805                 810                 815     


Glu Tyr Asp Ile Tyr Glu Glu Lys Val Glu Phe Lys Ile Asp Ser Ser 
            820                 825                 830         


Gly His Phe Ala Asp Tyr Tyr Lys Lys Ala Leu Ser Lys Ala Tyr Asn 
        835                 840                 845             


Arg Leu Lys Ala Glu Arg Glu Ile Ala Arg Arg Thr Asn Lys Arg Leu 
    850                 855                 860                 


Pro Pro Ile Glu His Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile 
865                 870                 875                 880 


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
                885                 890                 895     


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asp Ser Gly Asn Leu Lys 
            900                 905                 910         


Leu Ser Thr Ile Lys Thr Ser Leu Asn Asn Thr Thr Gln Ile Lys Gln 
        915                 920                 925             


Lys Ile Leu Asn Lys Thr Ile Val Ala Glu Arg Lys Gln Lys Asn Tyr 
    930                 935                 940                 


Thr Glu Leu Arg Lys Tyr Val His Asp Arg Arg Leu Pro Asn Leu Phe 
945                 950                 955                 960 


Glu Tyr Val Glu Ala Asp Glu Ile Leu Leu Glu Trp Leu Leu Asp Glu 
                965                 970                 975     


Leu Met Ala Tyr Asn Ala Ala Lys Gln Gln Val Phe Asp Thr Ile Phe 
            980                 985                 990         


Met Leu Glu Lys Arg Ile Ile Glu  Thr Asp Pro Gln Glu  Leu Lys Ser 
        995                 1000                 1005             


Leu Phe  Thr Asn Glu Lys Gly  Gln Val Gln Thr Gly  Asn Ile Gln 
    1010                 1015                 1020             


His Lys  Pro Tyr Val Gln Trp  Leu Lys Asn Lys Gly  Leu Ile Asn 
    1025                 1030                 1035             


His Asn  Glu Lys Leu Phe Ile  Asn Met Val Arg Asn  Cys Phe Ser 
    1040                 1045                 1050             


His Asn  Gln Phe Pro Gln Arg  Glu Thr Met Glu Leu  Leu Ile Ser 
    1055                 1060                 1065             


Glu Trp  Gly Ala Gly Lys Ile  Ala Thr Gln Ile Leu  Thr Val Tyr 
    1070                 1075                 1080             


Asn Gln  Leu Ile Thr Asn Ile  Ile Asn Lys Ile 
    1085                 1090                 


<210>  1575
<211>  1214
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1575

Leu Ile Leu Ser Phe Ile Ile Phe Asn Phe Ile Val Ile Ile Asn Gln 
1               5                   10                  15      


His Thr Leu Asn Thr Tyr Thr Arg Lys Tyr Met Lys Asp Lys Ser Phe 
            20                  25                  30          


Ser Thr Ile Ser Ser Ala Ile Asn Glu Thr Ile Thr Thr Asp Asn Ile 
        35                  40                  45              


Lys Tyr Pro Glu Gln Leu Asn Leu Ile Leu Ser Lys Arg Leu Arg Pro 
    50                  55                  60                  


Lys Asn Glu Leu Gln Pro Leu Trp Ala Ala Tyr Phe Asn Met Ala Arg 
65                  70                  75                  80  


Tyr Asn Met Tyr Thr Thr Leu Val His Ile Ala Thr Ala Thr Gly Leu 
                85                  90                  95      


Ser Asp Glu Asp Asn Met Glu Asn Arg Met Asp Lys Met Arg Ile Leu 
            100                 105                 110         


Asn Glu Pro Val Glu Pro Glu Ile Glu His Arg Leu Arg Lys Leu Leu 
        115                 120                 125             


Cys Arg His Phe Pro Phe Ala Val Trp Met Ile Cys Ser Pro Ile Arg 
    130                 135                 140                 


Lys Lys Asp Ser Lys Glu Asp Ser Ala Asp Glu Asp Tyr Arg Val Ile 
145                 150                 155                 160 


Ser Val Lys Glu Leu Arg Asp Cys Leu Lys Thr Val Ser Tyr Thr Leu 
                165                 170                 175     


Asn Tyr Phe Arg Asn Tyr Tyr Ser His Thr Arg His Val Glu Thr Arg 
            180                 185                 190         


Ser Glu Asp Ile Ile Ala Ala Ser Arg Asn Ser Glu Lys Gln Thr Gly 
        195                 200                 205             


Ile Phe Leu Asn Lys Val Cys Thr Val Ala Thr Arg Arg Val Lys Ser 
    210                 215                 220                 


Arg Phe Ser Asp Lys Ser Asn Lys Gly Gln Ala Gly Met Ile Asp Asp 
225                 230                 235                 240 


Gln Ser Met Lys Phe Ile Thr Glu Gly Lys Val Lys Phe Arg Asn Asn 
                245                 250                 255     


Asn Gly Ile Lys Glu Thr Ile Tyr Asn Pro Asp His Phe Leu Tyr Pro 
            260                 265                 270         


Leu Phe Leu Asn Arg Ser Ser Ala Leu Arg Asp Gly Thr Asn Pro Glu 
        275                 280                 285             


Arg Leu Ser Thr Val Gly Lys Ile Gln Leu Ile Cys Leu Leu Leu Asp 
    290                 295                 300                 


Lys Lys Tyr Ile Thr Glu Phe Leu Asp Gln Ser Gly Phe Leu Ser Ala 
305                 310                 315                 320 


Phe Asn Asn Asp Ala Pro Ala Pro Lys Leu Ser Glu Arg Arg Leu Ile 
                325                 330                 335     


Leu Glu Val Leu Ser Asp Leu Arg Ile Arg Leu Pro Gln Arg Lys Ile 
            340                 345                 350         


Asp Ala Thr Cys Asn Asp Ile Gln Val Ala Leu Asp Met Leu Asn Glu 
        355                 360                 365             


Leu Lys Lys Cys Pro Lys Glu Leu Phe Glu Leu Leu Glu Ala Lys Asp 
    370                 375                 380                 


Lys Ala Thr Phe Ser Ile Leu Ser Ser Thr Gly Glu His Ile Leu Leu 
385                 390                 395                 400 


Arg Arg Ser Ser Asp Arg Phe Thr Gln Leu Ala Leu Gln Trp Phe Asp 
                405                 410                 415     


Val Asn Lys Ala Phe Ser Arg Ile Arg Phe His Met Asn Ala Gly Ile 
            420                 425                 430         


Phe Arg Tyr Leu Phe Asn Asp Ser Lys Thr Cys Ile Asp Gly Lys Thr 
        435                 440                 445             


Arg Leu Arg Val Leu Gln Glu Pro Leu Asn Cys Phe Gly Arg Ile Gln 
    450                 455                 460                 


Glu Val Glu Asp Ser Arg Glu Ser Asn Arg Asp Gly Asn Asp Gly Pro 
465                 470                 475                 480 


Trp Arg Gly Phe Glu Ile Lys Gly Phe Asp Glu Ala Ala Arg Asn Asp 
                485                 490                 495     


Val Asn Cys Leu Pro Tyr Ile Asn Asp Ser Arg Thr Arg Tyr Leu Ile 
            500                 505                 510         


Thr Glu Asp Asn Ile Gly Ile Arg Phe Ser Gly Asp Asp Glu Ala Cys 
        515                 520                 525             


Gly Asn Tyr Phe Pro Arg Ile Asp Glu Lys Asn Gly Lys Tyr Lys Val 
    530                 535                 540                 


Thr Cys Leu Pro Ala Gln Cys Met Ile Ser Ile Tyr Glu Leu Gln Ala 
545                 550                 555                 560 


Met Leu Phe Leu His Leu Leu Asn Pro Gly Asn Asp Gly Gly Ile Ala 
                565                 570                 575     


Pro Val Glu Lys Ile Ile Ile Asp Lys Val Glu Ser Tyr Arg Arg Phe 
            580                 585                 590         


Phe Ser Asp Ile Lys Asn Gly Leu Leu Thr Pro Ser Gly Leu Thr Glu 
        595                 600                 605             


Ser Ser Leu Asn Asp Lys Leu Thr Ser Thr Tyr Gly Ile Ser Leu Ser 
    610                 615                 620                 


Asp Ile Pro Asp Lys Met Lys Asp Tyr Leu Leu Lys Lys Asn Asn Lys 
625                 630                 635                 640 


Gly Arg Gly Phe Asn Ala Tyr Arg Asp Arg Leu Ile Glu Thr Leu Lys 
                645                 650                 655     


Glu Glu Thr Glu Tyr Arg Ile Lys Arg Leu Glu Glu Asn Leu Asn Ala 
            660                 665                 670         


Thr Asn Ser Asp Thr Asn Lys Pro Gly Lys Pro Gly Tyr Val Gln Ile 
        675                 680                 685             


Lys Pro Gly Ser Leu Ala Ser Phe Ile Ser Lys Asp Ile Val Phe Phe 
    690                 695                 700                 


Gln Glu Cys Asn Ala Asp Gln Lys Met Thr Gly Leu Asn Phe Ser Val 
705                 710                 715                 720 


Met Gln Gly Leu Ile Ala Thr Phe Gly Ser Gln Glu Gly Ala Thr Thr 
                725                 730                 735     


Asp Asp Leu Arg Met Ala Phe Arg Lys Ser Gly Leu Ile Ala Ala Asn 
            740                 745                 750         


Gly Ser Cys Gly Thr His Pro Phe Leu Ala Ile Ala Phe Asn Ala Gly 
        755                 760                 765             


Ala Lys Asn Thr Val Asp Leu Tyr Lys Glu Tyr Leu Asn Ala Arg Lys 
    770                 775                 780                 


Ser Tyr Leu Ser Gly Ile Ile Pro Asp Asn Ala Pro Phe Leu His Ala 
785                 790                 795                 800 


Asp Arg Ile Arg Trp Ala Val Asn Asp Asp Ala Tyr Tyr Lys Asp Tyr 
                805                 810                 815     


Ala Glu Arg Cys Leu Gln Arg Pro Val Ile Leu Pro Arg Arg Leu Phe 
            820                 825                 830         


Glu Ala Ser Ile Arg Glu Asn Leu Leu Ala Leu Asn Gly Glu Asn Ala 
        835                 840                 845             


Asn Ala Leu Lys Lys Val Ile Ile Gly Ala Gly Gly His Cys Asn Ser 
    850                 855                 860                 


Ala Phe Met Ile Asp Ser Tyr Phe Tyr Tyr Val Lys Asn Asp Ser Pro 
865                 870                 875                 880 


Gln Val Phe His Gly Ala Cys Glu Gly Asp Met Leu His Thr Tyr Gly 
                885                 890                 895     


His Arg Phe Phe Gln Val Val Arg Arg Asn Leu Lys Asn Ala Glu Ala 
            900                 905                 910         


Ile Leu Ser Lys Leu Lys Lys Asp Ser Asn Thr His Asn Thr Tyr Ile 
        915                 920                 925             


Gly Ala Leu Ser Asp Ala Ile Cys Trp Ala Lys Glu Asn Pro Ile Lys 
    930                 935                 940                 


Pro Thr Phe Ser Val Gly Arg Ser Arg Leu Asn Asn His Ser Glu Asn 
945                 950                 955                 960 


Glu Ile Ala Ala Met Ile Lys Arg Ala Phe Asn Glu Tyr Met Ala Thr 
                965                 970                 975     


Glu Lys Thr Leu Arg Arg Tyr Val Ile Gln Asp Glu Leu Leu Phe Leu 
            980                 985                 990         


Ala Ala Met Lys Thr Ile Lys Ser  Lys Leu Gly Val Pro  Asp Ser Glu 
        995                 1000                 1005             


Trp Lys  Leu Gly Ser Ile Gly  Ser Lys Ser Gly Ser  Ile Leu Asp 
    1010                 1015                 1020             


Lys Glu  Leu Pro Leu Ile Gln  Thr Pro Ala Lys Phe  Ser Asn Ile 
    1025                 1030                 1035             


Lys Arg  Arg Pro Asn Lys Thr  Ile Thr Lys Asp Leu  Val Glu Leu 
    1040                 1045                 1050             


Val Ile  Glu Gln His Asn Val  Ser Ile Lys Asp Tyr  Gly Glu Ile 
    1055                 1060                 1065             


Tyr Arg  Ile Leu Ala Asp Glu  Arg Leu Tyr Gly Leu  Leu Lys Tyr 
    1070                 1075                 1080             


His Lys  Asn Glu Thr Val Leu  Ala Ser Asp Leu Lys  Asn Glu Ile 
    1085                 1090                 1095             


Glu Lys  Tyr Asp Glu Lys Arg  Val Lys Val Phe Glu  Asp Ile Met 
    1100                 1105                 1110             


Asn Tyr  Glu Lys Lys Ile Thr  Asn Gly Val Thr Asp  Arg Gln Leu 
    1115                 1120                 1125             


Cys Glu  Ser Met Asp His Ala  Lys Asp Ile Asp Phe  Lys Val Met 
    1130                 1135                 1140             


Gln Thr  Phe Asp Thr Met Asn  Asp Asn Leu Thr Lys  Met Glu Leu 
    1145                 1150                 1155             


Arg Ser  Ile Arg Asn Ala Phe  Cys His Asn Ser Tyr  Pro Asp Val 
    1160                 1165                 1170             


Asn Ala  Phe Asp Asn Ser Ser  Gly Thr Thr Lys Arg  Ile Arg Ile 
    1175                 1180                 1185             


His Asn  Ala Tyr Ile Pro Gly  Thr Ala Glu Lys Ile  Ser Glu Ile 
    1190                 1195                 1200             


Val Asn  Asp Ile Ser Ser Lys  Thr Lys Ala Lys 
    1205                 1210                 


<210>  1576
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1576

Met Glu Thr Lys Gln Gln Val Gly Lys Gly Ile Ser Tyr Asp His Arg 
1               5                   10                  15      


Arg Pro Asp Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asp Gly Val Ile Gln Glu Phe Ala Met Arg Leu Asn Arg 
        35                  40                  45              


Glu Tyr Asp Pro Glu Asn Lys Asn Gln Ser Leu Phe Ser Tyr Phe Asn 
    50                  55                  60                  


Ile Asn Ala Ser Phe Thr Asp Trp Glu Arg Gly Val Asn Ile Leu Lys 
65                  70                  75                  80  


Glu Tyr Trp Pro Met Met Glu Phe Ile Asp Arg Pro Ala Thr Asp Lys 
                85                  90                  95      


Gln Phe Glu Ala Glu Lys Pro Glu Asn Arg Glu Ala Ala Lys Arg Lys 
            100                 105                 110         


Tyr Phe Leu Ala Thr Leu Gly Ala Leu Leu Thr Ser Ile Lys Asp Leu 
        115                 120                 125             


Arg His Tyr Tyr Thr His Tyr Tyr His Pro Pro Val His Leu Asn Asp 
    130                 135                 140                 


Asp Leu Phe Leu Phe Leu Asp His Ala Leu Leu Tyr Thr Ala Phe Asp 
145                 150                 155                 160 


Val Lys Lys Thr Lys Met Lys Asp Asp Lys Thr Arg Gln Leu Leu Asn 
                165                 170                 175     


Gln Asn Leu Ser Leu Glu Leu Glu Lys Leu Lys Lys Leu Lys Val Glu 
            180                 185                 190         


Glu Leu Lys Lys Lys Lys Glu Lys Gly Ile Lys Val Asn Leu Gln Asp 
        195                 200                 205             


Glu Lys Gly Ile Leu Asn Ala Ile Tyr Asn Asp Ala Phe Ala His Ile 
    210                 215                 220                 


Ile Thr Lys Glu Lys Asp Ser Asp Lys Asp Lys Leu Glu Thr Arg Tyr 
225                 230                 235                 240 


Lys Ser Ile Leu Pro Gln Asp Glu Ala Ala Glu Thr Gly Ile Asn Ile 
                245                 250                 255     


Ser Ile Ser Gly Leu Ile Phe Leu Leu Ser Leu Phe Leu Ser Arg Lys 
            260                 265                 270         


Glu Ile Glu Gln Leu Lys Ser Asn Ile Glu Gly Tyr Lys Gly Lys Val 
        275                 280                 285             


Leu Asn Ile Glu Thr Glu Val Asp Arg Lys His Asn Ser Leu Lys Tyr 
    290                 295                 300                 


Met Ala Thr His Trp Val Phe Ser Ile Leu Ala Phe Lys Gly Leu Lys 
305                 310                 315                 320 


Gln Arg Leu Thr Asn Ser Phe Glu Lys Glu Ser Leu Leu Ile Gln Met 
                325                 330                 335     


Met Asp Glu Leu Asn Lys Val Pro Asp Glu Leu Tyr Gln Thr Leu Ser 
            340                 345                 350         


Glu Thr Ala Lys Lys Glu Phe Leu Glu Asp Ile Asn Glu Tyr Val Ser 
        355                 360                 365             


Glu Gly Asp Asp Asn Glu Lys Ala Thr Tyr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Ser Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gln Phe Pro Thr Leu Lys Phe Gln Ile Phe Val Gly 
                405                 410                 415     


Gln Tyr Leu His Asp Asn Arg Pro Lys Thr Leu Ala Ser Asn Gly Met 
            420                 425                 430         


Thr Ala Gln Arg Met Ile Lys Glu Lys Ile Asn Leu Phe Gly Asn Leu 
        435                 440                 445             


Ser Glu Val Thr Lys His Lys Ser Asp Phe Phe Glu Lys Glu Ser Ala 
    450                 455                 460                 


Ala Gln Gly Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Trp Ala Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Val Tyr Ile Asp Met Ile Gly Lys Glu Gly Lys Ala 
                485                 490                 495     


Lys Glu Ile Gln Val Gln Ile Asn Lys Tyr Arg Lys Gln Leu Asn Pro 
            500                 505                 510         


Ala Pro Gln Arg Asp Lys Arg Ile Ser Lys Lys Glu Ile Ile Glu Gln 
        515                 520                 525             


Leu Tyr Lys Glu Lys Val Val Tyr Gly Asp Pro Thr Leu Met Leu Ser 
    530                 535                 540                 


Ala Asn Glu Leu Met Ala Leu Leu Tyr Glu Leu Ile Val Asn Gly Lys 
545                 550                 555                 560 


Ser Gly Ala Glu Leu Glu Asn Lys Ile Val Glu Gln Ile Ile Ala Arg 
                565                 570                 575     


Tyr Glu Gln Ile Glu Ala Tyr Asp Pro Thr Thr Gln Gln Leu Pro Thr 
            580                 585                 590         


Asn Gln Met Pro His Lys Leu Gln Lys Ser Arg Lys Asp Ser Lys Val 
        595                 600                 605             


Thr Asp Thr Asp Lys Leu Leu Lys Thr Ile Asp Lys Glu Ile Asp Glu 
    610                 615                 620                 


Gly Asn Lys Lys Leu Glu Leu Ile Ala Cys His Arg Lys Glu Trp Glu 
625                 630                 635                 640 


Glu Ala Glu Gln Arg Lys Lys Ser Gly Lys Arg Asn Asn Pro Gly Thr 
                645                 650                 655     


Lys Ser Arg Lys His Leu Phe Tyr Ala Ser Glu Met Gly Glu Glu Ala 
            660                 665                 670         


Thr Trp Ile Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Pro Ala Arg 
        675                 680                 685             


Ala Glu Trp Lys Gly Thr His His Ser Glu Leu Gln Arg Leu Leu Ala 
    690                 695                 700                 


Phe Tyr Ser Thr Gln Arg Leu Glu Ala Trp Gln Leu Val Glu Ser Val 
705                 710                 715                 720 


Trp Thr Ala Asn Thr His Ser Phe Trp Glu Glu Asn Phe Lys Glu Ala 
                725                 730                 735     


Phe Tyr Lys Pro Glu Phe Glu Asn Phe Tyr Gly Ala Tyr Ile Glu Ile 
            740                 745                 750         


Arg Thr Lys Ile Leu Thr Thr Cys Arg Ser Ile Leu Glu Asn Asn Pro 
        755                 760                 765             


Glu Ala Thr Met Asn Asn Asp Thr Glu Lys Glu Trp Asp Lys Val Phe 
    770                 775                 780                 


Thr Leu Phe Asp Lys Arg Leu Tyr Arg Thr Ser Thr Thr Asp Glu Gln 
785                 790                 795                 800 


Lys Lys Gln Leu Leu Thr Lys Pro Phe Ala Phe Pro Arg Gly Leu Phe 
                805                 810                 815     


Asp Asp Lys Pro Thr Phe Leu Pro Gly Ser Lys Pro Asn Glu Asn Pro 
            820                 825                 830         


Glu Arg Phe Ala Ala Trp Tyr Ser Tyr Gly Tyr Thr Tyr Ser Gly Lys 
        835                 840                 845             


Phe Gln Ser Phe Tyr Asp Met Pro Arg Asn Tyr Ser Asp Trp Tyr Lys 
    850                 855                 860                 


Lys Leu Lys Glu Asp Gly Lys Leu Pro Arg Leu Asp Lys Lys Thr Glu 
865                 870                 875                 880 


Gln Glu Lys Ile Leu Arg Phe Arg Met Asp Cys Asp Leu Asn Ile Lys 
                885                 890                 895     


His Ile Arg Phe Gln Asp Ile Tyr Val Lys Leu Met Val Asp Ser Leu 
            900                 905                 910         


Tyr Lys Ala Val Phe Gly Gln Gln Pro Glu Phe Asp Leu Ser His Leu 
        915                 920                 925             


Tyr Asp Thr Arg Ser Glu Arg Tyr Glu Asn Asn Thr Ile Ala Gln Arg 
    930                 935                 940                 


Gln Lys Ser Arg Gln Glu Gly Asp Asn Ser Asp Asn Ala Ile Asn Glu 
945                 950                 955                 960 


Asn Tyr Val Trp Asn Lys Thr Phe Ala Ile Ser Leu Tyr Asn Gly Arg 
                965                 970                 975     


Ile Thr Glu Ser Gln Val Lys Leu Lys Asp Val Gly Lys Phe Arg Arg 
            980                 985                 990         


Phe Ala Thr Asp Pro Arg Val Gln  Thr Leu Ile Ser Tyr  Asp Asp Thr 
        995                 1000                 1005             


Arg Thr  Trp Thr Lys Leu Glu  Ile Glu Asn Glu Leu  Asp Asn Lys 
    1010                 1015                 1020             


Ala Asp  Ala Tyr Glu Pro Ile  Arg Arg Thr Gln Ser  Leu Lys Ala 
    1025                 1030                 1035             


Ile Gln  Gln Leu Glu Lys Asn  Ile Leu Lys Lys Asn  Gly Phe Asn 
    1040                 1045                 1050             


Gly Lys  Gln His Pro Glu Glu  Leu Lys His Asn Gly  Asn Pro Asn 
    1055                 1060                 1065             


Phe Arg  Lys Tyr Ile Ala Asn  Gly Leu Leu Lys His  Arg Thr Asp 
    1070                 1075                 1080             


Ile Arg  Gln Glu Glu Leu Ala  Leu Ile Ser Asp Thr  Glu Phe Gln 
    1085                 1090                 1095             


Glu Ile  Gly Leu Glu Arg Ile  Arg Gln Thr Asn Pro  Leu Ile Gln 
    1100                 1105                 1110             


Lys Ala  Tyr Leu Leu Ile Leu  Leu Arg Asn Lys Phe  Gly His Asn 
    1115                 1120                 1125             


Gln Leu  Pro Asp Gln Glu His  Phe Arg Leu Met Arg  Ser Ile Tyr 
    1130                 1135                 1140             


Pro Tyr  Asn Gln Gln Glu Ser  Tyr Ser Ala Tyr Phe  Asn His Val 
    1145                 1150                 1155             


Ile Thr  Gln Ile Ile Glu Glu  Leu Asn Thr 
    1160                 1165             


<210>  1577
<211>  1152
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1577

Met Asn Asp Tyr Ala Thr Arg Arg Pro Leu Gly Leu Arg Pro Ala Phe 
1               5                   10                  15      


Ala Gln Lys Pro Arg Thr Tyr Leu Asn Gly Asp Phe Val Arg Asp Met 
            20                  25                  30          


Lys Glu Leu Arg Ile Arg Gly Ser Ile Arg Asn Pro Gln Thr Arg Arg 
        35                  40                  45              


Asp Glu Thr Lys Asp Glu Thr Pro Gln Phe Ile Ala Tyr Leu Thr Ile 
    50                  55                  60                  


Ala Leu Gln Asn Ile Gly Glu Ile Leu Gly Lys Asp Val Asp Leu Ser 
65                  70                  75                  80  


Gly Phe Arg Lys Ser Asp Ala Val Lys Gln Ala Leu Lys Asp Ser Gly 
                85                  90                  95      


Lys Ile Tyr Glu Val Ala Ser Phe Leu Trp Leu His Arg Ala Asp Lys 
            100                 105                 110         


Thr Gly Arg Asp Phe Pro Asp Tyr Ala Glu Lys Ala Glu Ser Ile Val 
        115                 120                 125             


Leu Lys Ile Trp Glu Leu Arg Asn Met Phe Val His Ser Thr His Asp 
    130                 135                 140                 


Lys Ala Ser Lys Val Leu Ile Val Glu Pro Ser Phe Tyr Gln Phe Val 
145                 150                 155                 160 


Glu Gly Glu Leu Phe Ser Lys Ala Arg Arg Glu Asn Ala Leu Gly Leu 
                165                 170                 175     


Gly Arg Lys Ser Glu Lys Val Phe Lys Leu Arg Leu Phe Asn Pro Asn 
            180                 185                 190         


Asn Asp Ala Lys Thr Lys Tyr Glu Phe Thr Arg Lys Gly Met Ile Phe 
        195                 200                 205             


Leu Val Cys Leu Ala Leu Tyr Arg His Asp Ala Ala Glu Phe Leu Gln 
    210                 215                 220                 


Gln Phe Pro Asp Met Gln Leu Pro Pro Leu Glu Trp Gln Met Glu Arg 
225                 230                 235                 240 


Gly Leu Ala Pro Gln Met Ser Glu Glu Gln Leu Val Ala Leu Arg Lys 
                245                 250                 255     


Lys Gly Gly Ser Val Lys Ala Ile Leu Asp Ala Phe Thr Tyr Phe Ser 
            260                 265                 270         


Met Arg Ser Ser Arg Thr Asp Ile Asp Val Ala Asn Lys Glu Tyr Leu 
        275                 280                 285             


Asn Phe Ala Asn Ile Leu Leu Tyr Leu Asn Lys Val Pro Ser Ala Ala 
    290                 295                 300                 


Phe Pro Tyr Leu Ser Leu Asp Ser Glu Ala Lys Arg Leu Ala Asp Ala 
305                 310                 315                 320 


Ala Ser Gly Ser Asn Glu Ser Glu Glu Asn Arg Arg Phe Lys Tyr Val 
                325                 330                 335     


Leu Gln Glu Arg Lys Lys Asp Arg Phe Leu Thr Leu Ala Leu Ala Tyr 
            340                 345                 350         


Leu Glu Asp Phe His Lys Leu Asp Cys Ile Arg Phe Lys Arg Leu Asp 
        355                 360                 365             


Val Ser Val His Glu Gly Arg Ser Lys Phe Trp Phe Gly Pro Ile Pro 
    370                 375                 380                 


Glu Gly Ser Lys Asn Glu Arg Gly Glu Glu Ile Gln Asp Ala Asn Gly 
385                 390                 395                 400 


Met Asp Arg His Tyr Val Val Gly Gly Gly Val Ala Gln Phe Glu Phe 
                405                 410                 415     


Glu Pro Lys Glu His Tyr Gly Ala Ile Arg Ile Ala Ala Leu Arg Gly 
            420                 425                 430         


Gly Ile Gly Glu Asn Glu Ile Met Arg Leu Leu Leu Val Leu His Asp 
        435                 440                 445             


Gly Ala Ile Arg Arg Asn Asp Pro Asn Arg Ala Leu Glu Thr Tyr Leu 
    450                 455                 460                 


Ser Ala Tyr His Arg Ile Leu Glu Arg Met Leu Asn Ala Gln Ser Thr 
465                 470                 475                 480 


Asp Glu Leu Thr Leu Asp Asp Ala Gln Phe Arg Ala Asp Phe Asn Ala 
                485                 490                 495     


Val Arg Gly Arg Glu Pro Ser Ala Glu Leu Pro Arg Glu Thr Phe Val 
            500                 505                 510         


Glu Asp Met Arg Pro Phe Phe Ser Pro Ser Leu Thr Arg Phe Phe Val 
        515                 520                 525             


Gly Asp Glu Arg Lys Pro Ala Thr Asp Gln Leu Gln Ala Arg Leu Arg 
    530                 535                 540                 


Arg Arg Leu Ser Ala Leu Ser Gly Arg Ser Arg Asp Phe Leu Leu Lys 
545                 550                 555                 560 


Leu Asp Arg Leu Thr Glu Trp Lys Ala Leu Asp Glu Ala Glu Lys Glu 
                565                 570                 575     


Arg Arg Gly Lys Pro Thr Phe Lys Ile Gly Glu Leu Arg Phe Pro Pro 
            580                 585                 590         


Arg Thr Cys Arg Phe Thr Asp Ala Gln Leu Ile Arg Arg Val Leu Leu 
        595                 600                 605             


Tyr Leu Asn Ala Asn Leu Ser Gln Ala Asp Lys Phe Arg Gln Leu Pro 
    610                 615                 620                 


Arg Gly Lys Arg His Arg Gly Met Lys Asp Phe Asp Phe Gln Leu Leu 
625                 630                 635                 640 


His Ala Asp Ile Gly Arg Phe Gly Thr Asn Pro Ala Gly Leu Trp Lys 
                645                 650                 655     


Thr Leu Glu Arg Arg Glu Ser Leu Asn Ala Glu Gly Gly Ala Leu Glu 
            660                 665                 670         


Leu Leu Lys Glu Arg Glu Gly Glu Leu Phe Arg Glu Glu Gln Arg Arg 
        675                 680                 685             


Cys Arg Gly Lys Arg Asp Lys Asn Gly Arg Pro Leu Arg Pro Gly His 
    690                 695                 700                 


Thr Leu Thr Met Leu Ala Phe Ala Ala Thr Glu Leu Phe Ala Glu Val 
705                 710                 715                 720 


Cys Asp Gly Met Ala Glu Asp Tyr Cys Lys Pro Leu Ala Glu Glu Asp 
                725                 730                 735     


Ala Gly Val Leu Pro Tyr Val Cys Arg Ala Phe Gly Val Arg Thr Gly 
            740                 745                 750         


Gln Pro Leu Asp Arg Thr Ala Leu Val Lys Thr Val Leu Gly Ile Asp 
        755                 760                 765             


Leu Ala Ser Trp Gly Lys Ala Tyr Asp Tyr Asp Ala Lys Arg Pro Arg 
    770                 775                 780                 


Glu Thr Pro Arg Ser Leu Glu Asp Ala Arg Asn Leu Val Ala Ser Gln 
785                 790                 795                 800 


Ile Pro Val Pro Asn Asp Ile Ala Arg Arg Cys Val Glu Lys Gly Thr 
                805                 810                 815     


Arg Phe Asn Pro Ala Phe Arg Asp Phe Asp Pro Trp Gly Gly Gly Lys 
            820                 825                 830         


Met Lys Leu Arg Ala Phe Tyr Asp Val Ser Pro Leu Leu Ala Thr Met 
        835                 840                 845             


Glu Arg His Asp Ala Glu Arg Lys Gly Ala Arg Thr Ala Ala Arg Glu 
    850                 855                 860                 


Glu His Phe Trp Ser Asn Asp Asp Leu Phe Pro Tyr Ala Ala Asp Gly 
865                 870                 875                 880 


Val Glu Thr Arg Val Arg Pro Glu Thr Ala Pro Thr Leu Glu Asn Gly 
                885                 890                 895     


Glu Pro Val Pro Thr Glu Pro Gly Lys Thr Pro Pro Arg His Arg Pro 
            900                 905                 910         


Ser Phe Leu Arg Gly Asp Val Asn Lys Ala Ile Gln Gly Ile Leu Leu 
        915                 920                 925             


Ala Glu Arg Gln Asp Lys Val Leu Leu Ala Cys Ala Arg Glu Tyr Trp 
    930                 935                 940                 


Asn Arg Tyr Met Ser Ala Glu Val Pro Gly Ser Glu Gln Lys Glu Lys 
945                 950                 955                 960 


Ile Ala Gln Thr Phe Asn Phe Ser Asp Ala Ala Asp Ile Trp Glu Phe 
                965                 970                 975     


Phe Arg Met Ser Met Asp Asp Ala Phe Gly Asp Val Thr Val Arg Val 
            980                 985                 990         


Met Pro Asn Asp Phe Ala Arg Pro  Ala Tyr Gly Thr Val  Leu Ala His 
        995                 1000                 1005             


Leu Pro  Glu Leu Val Pro Met  Thr Lys Pro Leu Ser  Gly Thr Gln 
    1010                 1015                 1020             


Gly Val  Tyr Ala Phe Tyr Asp  Leu Trp Leu Ser Leu  Arg Asp Leu 
    1025                 1030                 1035             


Gln Arg  Lys Glu Ser Asp Leu  Arg Phe Asp Leu Ile  Pro Ala Thr 
    1040                 1045                 1050             


Ala Lys  Phe Asp Val Leu Ala  Glu Pro Val Pro Arg  Phe Arg Gly 
    1055                 1060                 1065             


Arg Glu  Lys Asp Glu Lys Lys  Glu Met Tyr Asp Ala  Leu Met His 
    1070                 1075                 1080             


Asp His  Leu Phe Glu His Tyr  Cys Lys Ala Leu Lys  Ile Ile Asn 
    1085                 1090                 1095             


Ser Gln  Pro Leu Thr Arg Glu  Glu Phe Asp Ala Ile  Leu Glu Leu 
    1100                 1105                 1110             


Gly Asn  Arg Leu Arg His Pro  Val Arg Asp Gly Val  Ser Leu Ser 
    1115                 1120                 1125             


Thr Met  Glu Lys Asp Gly Arg  Leu Ser Arg Ala Arg  Ala Ala Leu 
    1130                 1135                 1140             


Arg Arg  Phe Gly Cys Leu Arg  Thr Arg 
    1145                 1150         


<210>  1578
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1578

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Ile Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1579
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1579

Met Glu Thr Lys Gln Gln Val Gly Lys Gly Ile Ser Tyr Asp His Arg 
1               5                   10                  15      


Arg Pro Asp Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asp Gly Val Ile Gln Glu Phe Ala Met Arg Leu Asn Arg 
        35                  40                  45              


Glu Tyr Asp Pro Glu Asn Lys Asn Gln Ser Leu Phe Ser Tyr Phe Asn 
    50                  55                  60                  


Ile Asn Ala Ser Phe Thr Asp Trp Glu Arg Gly Val Asn Ile Leu Lys 
65                  70                  75                  80  


Glu Tyr Trp Pro Met Met Glu Phe Ile Asp Arg Pro Ala Thr Asp Lys 
                85                  90                  95      


Gln Phe Glu Ala Glu Lys Pro Glu Asn Arg Glu Ala Ala Lys Arg Lys 
            100                 105                 110         


Tyr Phe Leu Ala Thr Leu Gly Ala Leu Leu Thr Ser Ile Lys Asp Leu 
        115                 120                 125             


Arg His Tyr Tyr Thr His Tyr Tyr His Pro Pro Val His Leu Asn Asp 
    130                 135                 140                 


Asp Leu Phe Leu Phe Leu Asp His Ala Leu Leu Tyr Thr Ala Phe Asp 
145                 150                 155                 160 


Val Lys Lys Thr Lys Met Lys Asp Asp Lys Thr Arg Gln Leu Leu Asn 
                165                 170                 175     


Gln Asn Leu Ser Leu Glu Leu Glu Lys Leu Lys Lys Leu Lys Val Glu 
            180                 185                 190         


Glu Leu Lys Lys Lys Lys Glu Lys Gly Ile Lys Val Asn Leu Gln Asp 
        195                 200                 205             


Glu Lys Gly Ile Leu Asn Ala Ile Tyr Asn Asp Ala Phe Ala His Ile 
    210                 215                 220                 


Ile Thr Lys Glu Lys Asp Ser Asp Lys Asp Lys Leu Glu Thr Arg Tyr 
225                 230                 235                 240 


Lys Ser Ile Leu Pro Gln Asp Glu Ala Ala Glu Thr Gly Ile Asn Ile 
                245                 250                 255     


Ser Ile Ser Gly Leu Ile Phe Leu Leu Ser Leu Phe Leu Ser Arg Lys 
            260                 265                 270         


Glu Ile Glu Gln Leu Lys Ser Asn Ile Glu Gly Tyr Lys Gly Lys Val 
        275                 280                 285             


Leu Asn Ile Glu Thr Glu Val Asp Arg Lys His Asn Ser Leu Lys Tyr 
    290                 295                 300                 


Met Ala Thr His Trp Val Phe Ser Ile Leu Ala Phe Lys Gly Leu Lys 
305                 310                 315                 320 


Gln Arg Leu Thr Asn Ser Phe Glu Lys Glu Ser Leu Leu Ile Gln Met 
                325                 330                 335     


Met Asp Glu Leu Asn Lys Val Pro Asp Glu Leu Tyr Gln Thr Leu Ser 
            340                 345                 350         


Glu Thr Ala Lys Lys Glu Phe Leu Glu Asp Ile Asn Glu Tyr Val Ser 
        355                 360                 365             


Glu Gly Asp Asp Asn Glu Lys Ala Thr Tyr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Ser Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gln Phe Pro Thr Leu Lys Phe Gln Ile Phe Val Gly 
                405                 410                 415     


Gln Tyr Leu His Asp Asn Arg Pro Lys Thr Leu Ala Ser Asn Gly Met 
            420                 425                 430         


Thr Ala Gln Arg Met Ile Lys Glu Lys Ile Asn Leu Phe Gly Asn Leu 
        435                 440                 445             


Ser Glu Val Thr Lys His Lys Ser Asp Phe Phe Glu Lys Glu Ser Ala 
    450                 455                 460                 


Ala Gln Gly Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Trp Ala Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Val Tyr Ile Asp Met Ile Gly Lys Glu Gly Lys Ala 
                485                 490                 495     


Lys Glu Ile Gln Val Gln Ile Asn Lys Tyr Arg Lys Gln Leu Asn Pro 
            500                 505                 510         


Ala Pro Gln Arg Asp Lys Arg Ile Ser Lys Lys Glu Ile Ile Glu Gln 
        515                 520                 525             


Leu Tyr Lys Glu Lys Val Val Tyr Gly Asp Pro Thr Leu Met Leu Ser 
    530                 535                 540                 


Ala Asn Glu Leu Met Ala Leu Leu Tyr Glu Leu Ile Val Asn Gly Lys 
545                 550                 555                 560 


Ser Gly Ala Glu Leu Glu Asn Lys Ile Val Glu Gln Ile Ile Ala Arg 
                565                 570                 575     


Tyr Glu Gln Ile Glu Ala Tyr Asp Pro Thr Thr Gln Gln Leu Pro Thr 
            580                 585                 590         


Asn Gln Met Pro His Lys Leu Gln Lys Ser Arg Lys Asp Ser Lys Val 
        595                 600                 605             


Thr Asp Thr Asp Lys Leu Leu Lys Thr Ile Asp Lys Glu Ile Asp Glu 
    610                 615                 620                 


Gly Asn Lys Lys Leu Glu Leu Ile Ala Cys His Arg Lys Glu Trp Glu 
625                 630                 635                 640 


Glu Ala Glu Gln Arg Lys Lys Ser Gly Lys Arg Asn Asn Pro Gly Thr 
                645                 650                 655     


Lys Ser Arg Lys His Leu Phe Tyr Ala Ser Glu Met Gly Glu Glu Ala 
            660                 665                 670         


Thr Trp Ile Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Pro Ala Arg 
        675                 680                 685             


Ala Glu Trp Lys Gly Thr His His Ser Glu Leu Gln Arg Leu Leu Ala 
    690                 695                 700                 


Phe Tyr Ser Thr Gln Arg Leu Glu Ala Trp Gln Leu Val Glu Ser Val 
705                 710                 715                 720 


Trp Thr Ala Asn Thr His Ser Phe Trp Glu Glu Asn Phe Lys Glu Ala 
                725                 730                 735     


Phe Tyr Lys Pro Glu Phe Glu Asn Phe Tyr Gly Ala Tyr Ile Glu Ile 
            740                 745                 750         


Arg Thr Lys Ile Leu Thr Thr Cys Arg Ser Ile Leu Glu Asn Asn Pro 
        755                 760                 765             


Glu Ala Thr Met Asn Asn Asp Thr Glu Lys Glu Trp Asp Lys Val Phe 
    770                 775                 780                 


Thr Leu Phe Asp Lys Arg Leu Tyr Arg Thr Ser Thr Thr Asp Glu Gln 
785                 790                 795                 800 


Lys Lys Gln Leu Leu Thr Lys Pro Phe Ala Phe Pro Arg Gly Leu Phe 
                805                 810                 815     


Asp Asp Lys Pro Thr Phe Leu Pro Gly Ser Lys Pro Asn Glu Asn Pro 
            820                 825                 830         


Glu Arg Phe Ala Ala Trp Tyr Ser Tyr Gly Tyr Thr Tyr Ser Gly Lys 
        835                 840                 845             


Phe Gln Ser Phe Tyr Asp Met Pro Arg Asn Tyr Ser Asp Trp Tyr Lys 
    850                 855                 860                 


Lys Leu Lys Glu Asp Gly Lys Leu Pro Arg Leu Asp Lys Lys Thr Glu 
865                 870                 875                 880 


Gln Glu Lys Ile Leu Arg Phe Arg Met Asp Cys Asp Leu Asn Ile Lys 
                885                 890                 895     


His Ile Arg Phe Gln Asp Ile Tyr Val Lys Leu Met Val Asp Ser Leu 
            900                 905                 910         


Tyr Lys Ala Val Phe Gly Gln Gln Pro Glu Phe Asp Leu Ser His Leu 
        915                 920                 925             


Tyr Asp Thr Arg Ser Glu Arg Tyr Glu Asn Asn Thr Ile Ala Gln Arg 
    930                 935                 940                 


Gln Lys Ser Arg Gln Glu Gly Asp Asn Ser Asp Asn Ala Ile Asn Glu 
945                 950                 955                 960 


Asn Tyr Val Trp Asn Lys Thr Phe Ala Ile Ser Leu Tyr Asn Gly Arg 
                965                 970                 975     


Ile Thr Glu Ser Gln Val Lys Leu Lys Asp Val Gly Lys Phe Arg Arg 
            980                 985                 990         


Phe Ala Thr Asp Pro Arg Val Gln  Thr Leu Ile Ser Tyr  Asp Asp Thr 
        995                 1000                 1005             


Arg Thr  Trp Thr Lys Leu Glu  Ile Glu Asn Glu Leu  Asp Asn Lys 
    1010                 1015                 1020             


Ala Asp  Ala Tyr Glu Pro Ile  Arg Arg Thr Gln Ser  Leu Lys Ala 
    1025                 1030                 1035             


Ile Gln  Gln Leu Glu Lys Asn  Ile Leu Lys Lys Asn  Gly Phe Asn 
    1040                 1045                 1050             


Gly Lys  Gln His Pro Glu Glu  Leu Lys His Asn Gly  Asn Pro Asn 
    1055                 1060                 1065             


Phe Arg  Lys Tyr Ile Ala Asn  Gly Leu Leu Lys His  Arg Thr Asp 
    1070                 1075                 1080             


Ile Arg  Gln Glu Glu Leu Ala  Leu Ile Ser Asp Thr  Glu Phe Gln 
    1085                 1090                 1095             


Glu Ile  Gly Leu Glu Arg Ile  Arg Gln Thr Asn Pro  Leu Ile Gln 
    1100                 1105                 1110             


Lys Ala  Tyr Leu Leu Ile Leu  Leu Arg Asn Lys Phe  Gly His Asn 
    1115                 1120                 1125             


Gln Leu  Pro Asp Gln Glu His  Phe Arg Leu Met Arg  Ser Ile Tyr 
    1130                 1135                 1140             


Pro Tyr  Asn Gln Gln Glu Ser  Tyr Ser Ala Tyr Phe  Asn His Val 
    1145                 1150                 1155             


Ile Thr  Gln Ile Ile Glu Glu  Leu Asn Thr 
    1160                 1165             


<210>  1580
<211>  1047
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1580

Met Glu Glu Gln Phe Leu Gln Lys Glu Arg Asn Met Gly Asp Asn Pro 
1               5                   10                  15      


Tyr Tyr Phe Cys His Phe Ile Asn Met Ala His His Asn Val Asn Leu 
            20                  25                  30          


Ile Leu Glu Glu Ile Tyr Asn Ser Val Tyr Glu Lys Tyr Thr Gln Asp 
        35                  40                  45              


Lys Glu Glu Asn Ile Lys Ala Ile Cys Asn Ser Met Ile Ser Lys Ser 
    50                  55                  60                  


Arg Lys Asn Pro Asp Glu Lys Ala Lys Met Met Asn Met Cys Ile Arg 
65                  70                  75                  80  


His Phe Pro Phe Leu Asp Tyr Tyr Lys Glu Lys Asp Gln Asn Ser Asp 
                85                  90                  95      


Val Leu Thr Ile Leu Leu Asn Gln Phe Leu Val Pro Leu His Gly Leu 
            100                 105                 110         


Arg Asn Gln Phe Ser His Tyr Lys His Pro Gln Glu Ala Tyr Cys Ile 
        115                 120                 125             


Ser Gly Phe Asp Leu Leu Phe Glu Gln Ala Lys Thr Gly Ala Gln Met 
    130                 135                 140                 


Arg Met Lys Tyr Ser Asp Glu Asp Ile Ser Lys Val Lys Ser Lys Val 
145                 150                 155                 160 


Val Asn His Asp Ser Ile Leu Thr Glu Arg Gly Ile Leu Phe Phe Ile 
                165                 170                 175     


Cys Leu Phe Leu Asp Lys Arg Asn Ile Tyr Leu Phe Leu Ser Lys Ile 
            180                 185                 190         


Lys Gly Phe Arg Asp Arg Arg Pro Asp Glu Lys Tyr Lys Ser Ala Thr 
        195                 200                 205             


Leu Glu Val Phe Ser Gln Tyr Tyr Cys His Val Pro Tyr Arg Lys Leu 
    210                 215                 220                 


Asp Ser Ser Asp Val Ala Leu Asp Met Leu Asn Glu Leu Asn Arg Cys 
225                 230                 235                 240 


Pro Lys Ala Leu Tyr Asp Val Leu Ser Asp Glu Asp Arg Glu Arg Phe 
                245                 250                 255     


Ile Val Asp Asn Val Glu Asn Ala Asp Asn Arg Asp Glu Ile Ser Asp 
            260                 265                 270         


Glu Asp Asp Glu Glu Met Pro Arg Ser Val Met Lys Arg Ser Asp Asp 
        275                 280                 285             


Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Glu Lys Gln Asn Asn Leu 
    290                 295                 300                 


Asp Glu Ile Ser Phe His Leu Tyr Leu Gly Arg Lys Glu Ala Lys Pro 
305                 310                 315                 320 


Ala His Glu Lys Val Ile Asn Gly Glu Met Arg Thr His Lys Ile Leu 
                325                 330                 335     


Lys Asp Ile His Val Phe Gly Arg Leu Glu Asn Tyr Arg Asn Glu Glu 
            340                 345                 350         


Ile Cys Asn Ala Ile Lys Asn Arg Glu Asp Ile Glu Phe Tyr Ala Pro 
        355                 360                 365             


Ser Tyr Arg Ile Val Glu Asn Arg Ile Gly Leu Leu Leu Arg Arg Gln 
    370                 375                 380                 


Asn Asp Phe Thr Leu Glu Glu Ala Asn Glu Glu Lys Ile Phe Glu Gly 
385                 390                 395                 400 


Asn Leu Cys Pro Asp Val Ile Leu Ser Thr His Glu Leu Gly Ala Leu 
                405                 410                 415     


Phe Phe Tyr Asn Tyr Leu His Lys Lys Gly Trp Ile Glu Ser Ala Pro 
            420                 425                 430         


Tyr Leu Tyr Ile Arg Asn Phe Ile Ser Asp Phe Lys Arg Phe Ile Glu 
        435                 440                 445             


Asp Ile Lys Asn Gly Lys Leu Thr Pro Val Glu Ser Glu Asp Asp Phe 
    450                 455                 460                 


Tyr Leu Ile Lys Lys Lys Lys Arg Asp Glu Thr Lys Asp Asn Asp Lys 
465                 470                 475                 480 


Lys Ser Ile Ala Val Gln Glu Arg Arg Arg Glu Lys Leu Lys Glu Lys 
                485                 490                 495     


Leu Lys Gly Tyr His Leu Glu Pro Asp Trp Ile Pro Asp Ala Cys Arg 
            500                 505                 510         


Glu Tyr Met Leu Gly Tyr Lys Ala Asp Gln Lys Asp Tyr Tyr Thr Lys 
        515                 520                 525             


Gln Arg Phe Cys Ser Met Lys Lys Glu Thr Asp Ser Arg Ile Lys Gln 
    530                 535                 540                 


Ile Glu Ala Ile Arg Lys Arg Glu Asp Asn Ser Ile Ile Arg Gln Thr 
545                 550                 555                 560 


Arg Val Gly Glu Ile Ala Gln Glu Leu Ala Arg Asp Ile Val Phe Leu 
                565                 570                 575     


Ile Pro Pro Tyr Lys Asn Glu Lys Gly Ala Asp Thr Lys Ile Asn Asn 
            580                 585                 590         


Met Glu Phe Asp Val Leu Gln Lys Met Leu Ala Tyr Phe Pro Leu Asn 
        595                 600                 605             


Lys Lys Asp Ile Tyr Pro Phe Leu Lys Asn Ile Arg Asn Trp Asp Lys 
    610                 615                 620                 


His Pro Phe Leu Lys Tyr Thr Leu His Thr Glu His Gln Ser Leu Leu 
625                 630                 635                 640 


Asp Phe Tyr Gln Asp Tyr Leu Asn Cys Lys Lys Arg Trp Ile Ser Lys 
                645                 650                 655     


Asn Ile Arg Tyr Asp Lys Gln Lys Gly Asn Tyr Leu Val Asp Ala Asn 
            660                 665                 670         


Lys Thr Glu Gln Glu Cys Arg Tyr Phe Leu Lys Thr Asp Lys Leu Arg 
        675                 680                 685             


Thr Ala Lys Glu Lys Glu Tyr Phe Glu Glu Pro Asp Lys Pro Val Tyr 
    690                 695                 700                 


Leu Pro Thr Gly Phe Phe Val Asp Pro Ile Val Glu Ala Met Arg Lys 
705                 710                 715                 720 


Asn Gly Tyr Glu Leu Lys Glu Asn Ser Asn Ile Val Gly Cys Leu Lys 
                725                 730                 735     


Ile Tyr Phe Val Ser Lys Ile Gln Pro Met Tyr Asp Leu Ser Arg Tyr 
            740                 745                 750         


Tyr Thr Tyr Tyr Asp Gly Lys Glu Glu Arg Ser Met Gln Leu Asp Asp 
        755                 760                 765             


Leu Lys Val Phe Ile Lys Glu Lys Phe Gly Asn Lys Arg Thr Asp Asp 
    770                 775                 780                 


Asn Thr Ile Arg Phe Leu Lys Lys Ala Ala Lys Arg Ile Arg Glu Asn 
785                 790                 795                 800 


Glu Ser Glu Ile Leu Val Arg Gln Met Asp Asp Cys Ala Leu Phe Leu 
                805                 810                 815     


Met Val Asn Asp Leu Leu Glu Gly Gly Lys Phe Asn Asp Glu Asp Ile 
            820                 825                 830         


Glu Asn Ile Gly Tyr Asn Lys His His Asn Leu Leu Asp His Glu Tyr 
        835                 840                 845             


Asp Met Cys Glu Thr Ile Tyr Gly Arg Lys Val Thr Ala Arg Leu Pro 
    850                 855                 860                 


Ile Lys Arg Tyr Gly Glu Phe Arg Arg Phe Met Lys Asp Arg Arg Leu 
865                 870                 875                 880 


Gln Asn Leu Val Lys Tyr Tyr Pro Gly Asp His Glu Thr Pro Ile Pro 
                885                 890                 895     


Ser Gly Ile Pro Glu Ser Gly Lys Ala Met Glu Lys Asn Lys Lys Tyr 
            900                 905                 910         


Thr Tyr Ser Asn Leu Cys Asp Glu Leu Glu Ile Tyr Asp Lys Glu Arg 
        915                 920                 925             


Asp Asn Val Leu Asn Leu Ile Tyr Glu Val Asp Lys Ile Leu Val Asp 
    930                 935                 940                 


His Phe Pro Asp Lys Ile Met Lys Glu Glu Asp Gly Tyr Tyr Glu His 
945                 950                 955                 960 


Tyr His Cys Leu Asp Phe Ala Lys Lys Glu Phe Gly Leu Glu Ser Asp 
                965                 970                 975     


Val Glu Leu Leu Ser Gln Asp Asn Phe Lys Asp Leu Arg Asn Ala Leu 
            980                 985                 990         


Tyr His Asn Gln Ile Pro Tyr Asn  Asp Trp Val Ala Asp  Lys Ile Ser 
        995                 1000                 1005             


Lys Asp  Thr Glu Glu Pro Met  Tyr Val Arg Arg Ile  Phe Ser Phe 
    1010                 1015                 1020             


Ile Arg  Thr Val Tyr Ser Arg  Leu Leu Asp Gln Ile  Lys Ile Lys 
    1025                 1030                 1035             


Ile Glu  Lys Asp Glu Tyr Lys  Cys Lys 
    1040                 1045         


<210>  1581
<211>  1216
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1581

Met Asp Asn Arg Leu Ser Lys Asn Arg Ala Leu Leu Ala Ala Tyr Leu 
1               5                   10                  15      


Asn Met Ala Gln Gln Asn Ile Tyr Ile Thr Leu Leu His Ile Ser Gln 
            20                  25                  30          


Leu Met Gly Val Glu Glu Thr Lys Asp Leu Ser Asn Arg Met Tyr Asp 
        35                  40                  45              


Phe Gln Ile Leu Gln Glu Leu Lys Thr Gly Lys Lys Gly Ala Glu Ser 
    50                  55                  60                  


Glu Gln Met Ile Lys Ser Glu Arg Val Gln Lys Ile Ile Leu Leu Leu 
65                  70                  75                  80  


His Arg His Phe Pro Phe Leu Gln Ala Phe Val Glu Thr Lys His Leu 
                85                  90                  95      


Gln Gln Lys Lys Asn Lys Glu Glu Gly Lys Asn Ala Gln Lys Asn Lys 
            100                 105                 110         


Lys Gly Asn Ala Ile Pro Asn Asn Lys Gly Gln Leu Glu Phe Thr Val 
        115                 120                 125             


Ser Glu Ser Glu Lys Gln Ser Ile Ser Pro Asn Glu Tyr Arg Thr Ile 
    130                 135                 140                 


Leu Cys Asn Thr Phe Arg Leu Ile Asn Asp Leu Arg Asn Glu Tyr Thr 
145                 150                 155                 160 


His Phe Ser Pro Gly Lys Arg Thr Asp Lys Glu Lys Glu Ser His Lys 
                165                 170                 175     


Asn Thr Gln Lys Glu Met Leu Ser Tyr Leu Tyr Leu Cys Leu Asp Gly 
            180                 185                 190         


Gly Arg Arg Val Val Lys Glu Arg Phe Lys Asp Thr Phe Lys Glu Lys 
        195                 200                 205             


Asp Phe Asn Phe Leu Thr Gln Gly Pro Arg Tyr Ser Leu Gln Lys Glu 
    210                 215                 220                 


Arg Gly Lys Thr Lys Ala Glu Glu Arg Pro Asn Phe Tyr Tyr Arg Leu 
225                 230                 235                 240 


Lys Asp Asp Gln Gly Leu Phe Ser Tyr Val Gly Ile Leu Leu Phe Ile 
                245                 250                 255     


Ser Leu Phe Leu His Lys Arg Tyr Ile Ser Glu Met Leu Thr Gln Ser 
            260                 265                 270         


Gly Leu Phe Tyr Thr Pro Arg Tyr Trp Lys Gly Gln Pro Val Asp Val 
        275                 280                 285             


Glu Leu Glu Arg Arg Ile Ile Ser Glu Ile Phe Ser Ile Tyr Arg Ile 
    290                 295                 300                 


Arg Leu Pro Lys Glu Arg Ile Glu Ser Thr Arg Pro Asp Tyr Ala Leu 
305                 310                 315                 320 


Gly Leu Asp Met Leu Asn Glu Leu Gln Lys Cys Pro Asp Glu Leu Tyr 
                325                 330                 335     


Glu Thr Phe Ser Pro Glu Asp Gln Ala Glu Phe Arg Val Lys Arg Glu 
            340                 345                 350         


Tyr Asp Glu Ser Gly Glu Gly Thr Glu Gly Gly Glu Val Leu Leu Lys 
        355                 360                 365             


Arg Phe Asp Asp Arg Phe Pro Tyr Phe Ala Ile Arg Tyr Leu Asp Glu 
    370                 375                 380                 


Asn Leu Val Phe Asp Asp Ile Arg Phe Gln Val Ser Ile Gly Lys Tyr 
385                 390                 395                 400 


Arg Tyr Lys Phe Tyr Asn Lys Leu Cys Ile Asp Val Val Ser Pro His 
                405                 410                 415     


Glu Asp Asp Cys Tyr Arg Leu Arg Ser Leu Gln Lys Asp Ile Asn Gly 
            420                 425                 430         


Phe Gly Arg Leu Asn Glu Val Glu Tyr Glu Arg Met Leu Arg Tyr Gly 
        435                 440                 445             


Ser His Ile His Ala Glu Lys Pro Lys Gly Asp Asp Thr Pro Tyr Leu 
    450                 455                 460                 


Thr Asp His Tyr Thr Ser Tyr Val Phe Asn Gly Asn Arg Ile Gly Leu 
465                 470                 475                 480 


Leu Phe Asn Gln Glu Asn Gly Arg His Asp Leu Glu Glu Thr Arg Gly 
                485                 490                 495     


Thr Arg Leu Tyr Leu Pro Ser Leu Thr Phe Asp Ser Ser Ala Glu Gly 
            500                 505                 510         


Lys Asp Ala His Cys Val Ala Pro Ile Ala Trp Leu Ser Thr Tyr Glu 
        515                 520                 525             


Leu Pro Ala Leu Ile Phe His His Leu Leu Cys His His Tyr Gly Leu 
    530                 535                 540                 


Glu Arg Thr Ala Thr Glu Ala Ile Ile Lys Asp Cys Val Gly Leu Tyr 
545                 550                 555                 560 


His Arg Leu Phe Thr Asp Ile Arg Asp Gly Lys Leu Leu Pro Gly Glu 
                565                 570                 575     


Ala Leu Gly Ile Arg Ala Gly Glu Ser Leu Ser Gln Glu Ile Ser Gln 
            580                 585                 590         


Ile Arg Lys Gly Lys Pro Leu Pro Gln Asn Ile Ser Glu Lys Ile Glu 
        595                 600                 605             


Thr Phe Leu Thr Thr His Tyr Cys Thr Glu Arg Val Cys Leu His Ile 
    610                 615                 620                 


Gln Asp Ile Pro Lys Lys Leu Ile Asp Tyr Leu Ile Gly Lys Arg Leu 
625                 630                 635                 640 


Asp Gln Asp Met Ala Gly Leu Phe Lys Gln Arg Ser Arg Glu Leu Val 
                645                 650                 655     


Asn Lys Met Leu Glu Ser Thr Gln Val Arg Leu Lys Lys Phe Thr Glu 
            660                 665                 670         


Glu Trp Thr Arg Gln Gly Asn Arg Asp Asn Lys Phe Gly Lys Lys Ser 
        675                 680                 685             


Tyr Val Asp Ile Arg Pro Gly Arg Leu Ala Asp Tyr Leu Ala Lys Asp 
    690                 695                 700                 


Leu Leu Phe Phe Gln Pro Tyr Asp Asp Glu Lys Lys Asn Lys Val Thr 
705                 710                 715                 720 


Gly Leu Asn Tyr Gln Val Leu Gln Ala Ala Leu Ala Ile Tyr Asn His 
                725                 730                 735     


Ser Leu Asp Glu Leu Ser Arg Leu Phe Glu Asn Ala Arg Leu Leu Val 
            740                 745                 750         


Pro Glu Gly Pro Lys Met Glu His Pro Phe Leu Arg Ser Val Leu Lys 
        755                 760                 765             


Lys Lys Pro Asn Ser Thr Leu Gln Phe Tyr Ala Tyr Tyr Leu Ile Glu 
    770                 775                 780                 


Lys Ile Lys Tyr Leu Glu Gly Arg Leu Ala Asp Ser Asn Glu Thr Phe 
785                 790                 795                 800 


Ala Asp Leu Phe Arg Tyr Lys Gln Arg Gln Lys Trp Gln Thr Arg Asp 
                805                 810                 815     


Cys Gln Trp Tyr Arg Ala Leu Ala Gly Arg Tyr Met Ala Glu Met Met 
            820                 825                 830         


Glu Glu Gly Thr Met Asn Phe Lys Pro Ile Glu Leu Pro Arg Gly Leu 
        835                 840                 845             


Phe Glu Gln Pro Ile Lys Gln Leu Leu Ala Thr Ile Leu Thr Gln Arg 
    850                 855                 860                 


Thr Gly Ser Asp Ser Gln Ala Leu Leu Lys Ile Val Glu Ser Pro Arg 
865                 870                 875                 880 


Cys Asn Val Ser Tyr Leu Ile Ala Gln Tyr Phe Thr Leu Ile Leu His 
                885                 890                 895     


Asp Asp Ser Gln Pro Phe Tyr Arg Pro Asp Lys Arg Phe Lys Arg Thr 
            900                 905                 910         


Tyr Lys Tyr Phe Asn Ile Leu Asn Asn Arg Lys Glu Arg Asn Lys Leu 
        915                 920                 925             


Val Gln Val Tyr Gln Thr Leu Asp Glu Met Glu Ala Tyr Phe Lys Asp 
    930                 935                 940                 


Thr Glu Ser Leu Glu Lys Gln His Lys Asn Tyr Leu Asn Ser Pro Glu 
945                 950                 955                 960 


Ala Lys Lys His Pro Ala Pro Glu Ala Arg Leu Lys Lys Tyr Leu Ser 
                965                 970                 975     


Glu Tyr Arg Lys Asn Glu Thr Thr Ile Arg Arg Tyr Arg Val Gln Asp 
            980                 985                 990         


Met Leu Ile Phe Leu Met Ala Lys  Ile Leu Leu Leu Glu  Lys Gly Gly 
        995                 1000                 1005             


Leu Lys  Ala Gly Glu Leu Lys  Gln Tyr Lys Leu Ser  Leu Ile Gln 
    1010                 1015                 1020             


Pro Thr  Thr Gly Gln Asn Glu  Arg Gln Asn Ile Leu  Ser Leu Gln 
    1025                 1030                 1035             


Val Pro  Phe Ser Ile Thr Ile  Lys Leu Asn Asp Gly  Thr Glu Arg 
    1040                 1045                 1050             


Thr Ile  Thr Gln Glu Ala Ile  Lys Val Lys Asn Cys  Gly Asp Phe 
    1055                 1060                 1065             


Phe Arg  Phe Leu Tyr Asp Gly  Arg Val Ile Ser Leu  Leu Pro Tyr 
    1070                 1075                 1080             


Thr Gln  Glu Asp Ile Pro Leu  Glu Arg Ser Leu Leu  Asp Lys Glu 
    1085                 1090                 1095             


Leu Glu  Gly Tyr Asp Lys Glu  Arg Ile Pro Ile Phe  Lys Ser Val 
    1100                 1105                 1110             


His Arg  Met Glu Glu Glu Ile  Leu Arg Leu Cys Pro  Glu Leu Asn 
    1115                 1120                 1125             


Asn Pro  Gln Ser Pro Lys Tyr  Lys Tyr Thr Thr Asp  Ile Gly Lys 
    1130                 1135                 1140             


Glu Lys  Ile Val Lys Glu Asn  Phe Arg Ala Met Leu  Thr Glu Leu 
    1145                 1150                 1155             


His Asn  Arg Gly Leu Leu Pro  Glu Asn Glu Ile Glu  Met Met Val 
    1160                 1165                 1170             


Glu Ile  Arg Asn Ser Phe Ala  His Asn Arg Tyr Ala  Ser Val Thr 
    1175                 1180                 1185             


Leu Lys  Gly Lys Glu Ile Pro  Ile Ile Ala Ile Ser  Ile Gln Arg 
    1190                 1195                 1200             


Lys Phe  Asp Gly Val Val Gly  Arg Thr Ile Gly Lys  Lys 
    1205                 1210                 1215     


<210>  1582
<211>  1125
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1582

Met Glu Asp Asp Lys Lys Thr Lys Glu Ser Thr Asn Met Leu Asp Asn 
1               5                   10                  15      


Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val Tyr 
            20                  25                  30          


Ile Thr Val Asn His Ile Asn Lys Val Leu Glu Leu Lys Asn Lys Lys 
        35                  40                  45              


Asp Gln Asp Ile Ile Ile Asp Asn Asp Gln Asp Ile Leu Ala Ile Lys 
    50                  55                  60                  


Thr His Trp Glu Lys Val Asp Gly Asp Leu Asn Lys Thr Glu Arg Leu 
65                  70                  75                  80  


Arg Glu Leu Met Thr Lys His Phe Pro Phe Leu Glu Thr Ala Ile Tyr 
                85                  90                  95      


Thr Lys Asn Lys Glu Asp Lys Glu Glu Val Lys Gln Glu Lys Gln Ala 
            100                 105                 110         


Lys Ala Gln Ser Phe Asp Ser Leu Lys His Cys Leu Phe Leu Phe Leu 
        115                 120                 125             


Glu Lys Leu Gln Glu Ala Arg Asn Tyr Tyr Ser His Tyr Lys Tyr Ser 
    130                 135                 140                 


Glu Ser Thr Lys Glu Pro Met Leu Glu Lys Glu Leu Leu Lys Lys Met 
145                 150                 155                 160 


Tyr Asn Ile Phe Asp Asp Asn Ile Gln Leu Val Ile Lys Asp Tyr Gln 
                165                 170                 175     


His Asn Lys Asp Ile Asn Pro Asp Glu Asp Phe Lys His Leu Asp Arg 
            180                 185                 190         


Thr Glu Glu Glu Phe Asn Tyr Tyr Phe Thr Arg Asn Lys Lys Gly Asn 
        195                 200                 205             


Ile Thr Ala Ser Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys 
    210                 215                 220                 


Lys Asp Ala Ile Trp Met Gln Gln Lys Leu Arg Gly Phe Lys Asp Asn 
225                 230                 235                 240 


Arg Glu Ser Lys Lys Lys Met Thr His Glu Val Phe Cys Arg Ser Arg 
                245                 250                 255     


Met Leu Leu Pro Lys Leu Arg Leu Glu Ser Thr Gln Thr Gln Asp Trp 
            260                 265                 270         


Ile Leu Leu Asp Met Leu Asn Glu Leu Ile Arg Cys Pro Lys Ser Leu 
        275                 280                 285             


Tyr Glu Arg Leu Gln Gly Glu Asp Arg Glu Lys Phe Lys Val Pro Phe 
    290                 295                 300                 


Asp Pro Ala Asp Glu Asp Tyr Asp Ala Glu Gln Glu Pro Phe Lys Asn 
305                 310                 315                 320 


Thr Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr 
                325                 330                 335     


Phe Asp Tyr Asn Glu Ile Phe Thr Asn Leu Arg Phe Gln Ile Asp Leu 
            340                 345                 350         


Gly Thr Tyr His Phe Ser Ile Tyr Lys Lys Leu Ile Gly Gly Gln Lys 
        355                 360                 365             


Glu Asp Arg His Leu Thr His Lys Leu Tyr Gly Phe Glu Arg Ile Gln 
    370                 375                 380                 


Glu Phe Ala Lys Gln Asn Arg Pro Asp Glu Trp Lys Ala Ile Val Lys 
385                 390                 395                 400 


Asp Leu Asp Thr Tyr Glu Thr Ser Asn Glu Arg Tyr Ile Ser Glu Thr 
                405                 410                 415     


Thr Pro His Tyr His Leu Glu Asn Gln Lys Ile Gly Ile Arg Phe Arg 
            420                 425                 430         


Asn Gly Asn Lys Glu Ile Trp Pro Ser Leu Glu Thr Asn Gly Glu Asn 
        435                 440                 445             


Asn Glu Lys Arg Lys Tyr Lys Leu Asp Lys Gln Tyr Gln Ala Glu Ala 
    450                 455                 460                 


Phe Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu 
465                 470                 475                 480 


Leu Lys Lys Glu Glu Pro Asn Asn Asp Lys Lys Asn Ala Ser Ile Val 
                485                 490                 495     


Glu Gly Phe Ile Lys Arg Glu Ile Arg Asp Ile Tyr Lys Leu Tyr Asp 
            500                 505                 510         


Ala Phe Ala Asn Gly Glu Ile Asn Asn Ile Asp Asp Leu Glu Lys Tyr 
        515                 520                 525             


Cys Glu Asp Lys Gly Ile Pro Lys Arg His Leu Pro Lys Gln Met Val 
    530                 535                 540                 


Ala Ile Leu Tyr Asp Glu His Lys Asp Met Val Lys Glu Ala Lys Arg 
545                 550                 555                 560 


Lys Gln Lys Glu Met Val Lys Asp Thr Lys Lys Leu Leu Ala Thr Leu 
                565                 570                 575     


Glu Lys Gln Thr Gln Gly Glu Ile Glu Asp Gly Gly Arg Asn Ile Arg 
            580                 585                 590         


Leu Leu Lys Ser Gly Glu Ile Ala Arg Trp Leu Val Asn Asp Met Met 
        595                 600                 605             


Arg Phe Gln Pro Val Gln Lys Asp Asn Glu Gly Asn Pro Leu Asn Asn 
    610                 615                 620                 


Ser Lys Ala Asn Ser Thr Glu Tyr Gln Met Leu Gln Arg Ser Leu Ala 
625                 630                 635                 640 


Leu Tyr Asn Lys Glu Glu Lys Pro Thr Arg Tyr Phe Arg Gln Val Asn 
                645                 650                 655     


Leu Ile Asn Ser Ser Asn Pro His Pro Phe Leu Lys Trp Thr Lys Trp 
            660                 665                 670         


Glu Glu Cys Asn Asn Ile Leu Ser Phe Tyr Arg Ser Tyr Leu Thr Lys 
        675                 680                 685             


Lys Ile Glu Phe Leu Asn Lys Leu Lys Pro Glu Asp Trp Glu Lys Asn 
    690                 695                 700                 


Gln Tyr Phe Leu Lys Leu Lys Glu Pro Lys Thr Asn Arg Glu Thr Leu 
705                 710                 715                 720 


Val Gln Gly Trp Lys Asn Gly Phe Asn Leu Pro Arg Gly Ile Phe Thr 
                725                 730                 735     


Glu Pro Ile Arg Glu Trp Phe Lys Arg His Gln Asn Asn Ser Glu Glu 
            740                 745                 750         


Tyr Glu Lys Val Glu Ala Leu Asp Arg Val Gly Leu Val Thr Lys Val 
        755                 760                 765             


Ile Pro Leu Phe Phe Lys Glu Glu Tyr Phe Lys Glu Asp Ala Gln Lys 
    770                 775                 780                 


Glu Ile Asn Asn Cys Val Gln Pro Phe Tyr Ser Phe Pro Tyr Asn Val 
785                 790                 795                 800 


Gly Asn Ile His Lys Pro Asp Glu Lys Asp Phe Leu Pro Ser Glu Glu 
                805                 810                 815     


Arg Lys Lys Leu Trp Gly Asp Lys Lys Asp Lys Phe Lys Gly Tyr Lys 
            820                 825                 830         


Ala Lys Val Lys Ser Lys Lys Leu Thr Asp Lys Glu Lys Glu Glu Tyr 
        835                 840                 845             


Arg Ser Tyr Leu Glu Phe Gln Ser Trp Asn Lys Phe Glu Arg Glu Leu 
    850                 855                 860                 


Arg Leu Val Arg Asn Gln Asp Ile Val Thr Trp Leu Leu Cys Thr Glu 
865                 870                 875                 880 


Leu Ile Asp Lys Leu Lys Val Glu Gly Leu Asn Val Glu Glu Leu Gln 
                885                 890                 895     


Lys Leu Arg Leu Lys Asp Ile Asp Thr Asp Thr Ala Lys Gln Glu Lys 
            900                 905                 910         


Asn Asn Ile Leu Asn Arg Ile Met Pro Met Gln Leu Pro Val Thr Val 
        915                 920                 925             


Tyr Glu Ile Asp Asp Ser His Lys Ile Val Lys Asp Arg Pro Leu His 
    930                 935                 940                 


Thr Val Tyr Ile Glu Glu Thr Lys Thr Lys Leu Leu Lys Gln Gly Asn 
945                 950                 955                 960 


Phe Lys Ala Leu Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe 
                965                 970                 975     


Val Asp Thr Ser Ser Glu Ala Glu Leu Lys Asp Lys Pro Ile Ser Lys 
            980                 985                 990         


Ser Val Val Glu Tyr Glu Leu Gly  Glu Tyr Gln Asn Ala  Arg Ile Glu 
        995                 1000                 1005             


Thr Ile  Lys Asp Met Leu Leu  Leu Glu Glu Thr Leu  Ile Lys Lys 
    1010                 1015                 1020             


Tyr Lys  Thr Leu Pro Thr Asn  Lys Phe Lys Lys Met  Leu Lys Gly 
    1025                 1030                 1035             


Trp Leu  Glu Gly Lys Asp Glu  Ala Asp Lys Ala Arg  Phe Gln Asn 
    1040                 1045                 1050             


Asp Val  Lys Leu Leu Val Ala  Val Arg Asn Ala Phe  Ser His Asn 
    1055                 1060                 1065             


Gln Tyr  Pro Met Arg Asn Arg  Ile Ala Phe Ala Asn  Ile Asn Pro 
    1070                 1075                 1080             


Phe Ser  Leu Ser Ser Ala Asn  Thr Ser Glu Glu Lys  Gly Leu Gly 
    1085                 1090                 1095             


Ile Ala  Asn Gln Leu Lys Asp  Lys Thr Lys Glu Thr  Ile Glu Lys 
    1100                 1105                 1110             


Ile Ile  Lys Ile Glu Lys Pro  Ile Glu Thr Lys Glu  
    1115                 1120                 1125 


<210>  1583
<211>  1175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1583

Met Thr Glu Gln Asn Glu Arg Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Phe Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Ala His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Tyr Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Gly Lys Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Thr Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Leu Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Glu Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Asp Glu Ile Asn Thr Arg Asp 
    530                 535                 540                 


Glu Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Met Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Glu Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Gly Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Leu Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Asp Leu Glu Ala Trp Ser His Ser Ala Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Val Gly Ile Glu Tyr Ala Ser Pro Gly Asn 
    850                 855                 860                 


Lys Lys Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Glu Ala 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Arg Ala Asp Lys Ile Asn Ile Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Ala Lys Glu His Pro Tyr Leu Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asp Ile Arg Thr 
945                 950                 955                 960 


Glu Val Gln Glu Gln Gly Ser Leu Asn Val Leu Asn Arg Val Lys Pro 
                965                 970                 975     


Met Arg Leu Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val 
            980                 985                 990         


His Lys Glu Gln Ala Pro Leu Ala  Thr Val Tyr Ile Glu  Glu Arg Asp 
        995                 1000                 1005             


Thr Lys  Leu Leu Lys Gln Gly  Asn Phe Lys Ser Phe  Val Lys Asp 
    1010                 1015                 1020             


Arg Arg  Leu Asn Gly Leu Phe  Ser Phe Val Asn Thr  Gly Gly Leu 
    1025                 1030                 1035             


Ala Met  Glu Gln Tyr Pro Ile  Ser Lys Leu Arg Val  Glu Tyr Glu 
    1040                 1045                 1050             


Leu Ala  Lys Tyr Gln Thr Ala  Arg Val Cys Ala Phe  Glu Gln Thr 
    1055                 1060                 1065             


Leu Glu  Leu Glu Glu Ser Leu  Leu Thr Arg Tyr Pro  His Leu Pro 
    1070                 1075                 1080             


Asp Lys  Asn Phe Arg Lys Met  Leu Glu Ser Trp Ser  Asp Pro Leu 
    1085                 1090                 1095             


Leu Asp  Lys Trp Pro Asp Leu  His Arg Lys Val Arg  Leu Leu Ile 
    1100                 1105                 1110             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1115                 1120                 1125             


Glu Ala  Val Phe Ser Ser Ile  Arg Lys Tyr Asp Pro  Ser Ser Pro 
    1130                 1135                 1140             


Asp Ala  Ile Glu Glu Arg Met  Gly Leu Asn Ile Ala  His Arg Leu 
    1145                 1150                 1155             


Ser Glu  Glu Val Lys Gln Ala  Lys Lys Met Ala Glu  Arg Ile Ile 
    1160                 1165                 1170             


Gln Ala  
    1175 


<210>  1584
<211>  1313
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1584

Met Glu Lys Lys Gln Lys His Gln Gln Pro Ile Lys Asn Gln Asn Ser 
1               5                   10                  15      


Glu Asn His Tyr Ala Gly Ser Lys Pro Thr Lys Lys Tyr Gln Arg Arg 
            20                  25                  30          


Ser Pro Asn Ser Ile Gln Pro Glu Ala Asn Ser Lys Lys Leu Arg Pro 
        35                  40                  45              


Val Phe Ala Ala Tyr Leu Asn Met Ala Arg Ala Asn Leu Tyr Ala Val 
    50                  55                  60                  


Leu Arg His Ile Ser Val Ile Thr Gly Leu Asn Val Asn Lys Asp Glu 
65                  70                  75                  80  


Glu His Met Glu Gln Leu Pro Val Ser Arg Phe Ala Asn Gln Lys His 
                85                  90                  95      


Pro Glu Val Arg Gln Lys Val Tyr Thr Leu Leu Tyr Lys His Ile Pro 
            100                 105                 110         


Cys Leu Lys His Met Ser Gln Ala Tyr Ile Lys Lys Gly Lys Leu Asp 
        115                 120                 125             


Leu Asp Gly Asn Pro Ile Val Glu Glu His Lys Thr Val Thr Gln Ser 
    130                 135                 140                 


Asp Leu Gln Lys Leu Leu Gln Asn Ile Ile Arg Thr Leu Asn Tyr Gln 
145                 150                 155                 160 


Arg Asn Glu Phe Thr His Ala Asp His Tyr Asn Thr Glu Asn Glu Arg 
                165                 170                 175     


Glu Ala Glu Phe Lys Arg Gln Ser Asp Leu Phe Arg Pro Leu Ser Cys 
            180                 185                 190         


Ala Phe Ile Gly Ala Lys Arg Glu Thr Ser Arg Ile Phe Asn Tyr Asn 
        195                 200                 205             


Ala Asp Asp Met Phe Phe Ile Asp Gln Lys Glu Arg Met Glu Arg Thr 
    210                 215                 220                 


Asn Glu Leu Asn Glu Asp Gly Lys Pro Ile Tyr Arg Glu His Glu Asp 
225                 230                 235                 240 


Trp Tyr Phe Arg Leu Phe Thr Arg Ser Ala Lys Tyr Ile Arg Asn Asp 
                245                 250                 255     


Gln Gly Asp Ile Glu Ile Asn Asp Asp Asp Gly Ile Ile Gly Glu Asn 
            260                 265                 270         


Glu Ser Leu Gln Leu Thr Ser Ala Gly Leu Ile Phe Leu Ile Cys Lys 
        275                 280                 285             


Phe Leu His Lys Lys Tyr Ala Thr Gln Phe Ala Gln Gln Thr Gly Leu 
    290                 295                 300                 


Phe Arg Thr Arg Gly Gln Ser Gly Asn Ser Pro Phe Ser Ile Arg Glu 
305                 310                 315                 320 


Asn Glu Val Met Phe Asn Ile Phe Cys Ala His Arg Ile Arg Leu Pro 
                325                 330                 335     


Lys Gly Arg Ile Glu Ser Asn Thr Asp Lys Ser Ala Leu Gly Leu Asp 
            340                 345                 350         


Met Leu Asn Glu Leu Gln Lys Cys Pro Lys Glu Leu Phe Glu Thr Phe 
        355                 360                 365             


Ser Pro Ala Asp Arg Ser Leu Phe Gln Ile Val Arg Asn Gly Asn Thr 
    370                 375                 380                 


Asn Thr Pro Asn Pro Asp Asp Asp Val Asn Leu Phe Arg Arg Asn Asn 
385                 390                 395                 400 


Asp Arg Phe Ala Gln Leu Ala Leu Lys Tyr Ile Asp Ser Leu Arg Thr 
                405                 410                 415     


Asp Pro Thr Glu Leu Ser Asp Thr Phe Glu Gly Pro Leu Lys Thr Ile 
            420                 425                 430         


Val Phe Gln Ile Ala Ile Gly Lys Tyr Arg Tyr Lys Phe Tyr Asn Arg 
        435                 440                 445             


Ala Ser Leu Asp Thr Asp Val Lys Asp Arg Val Arg Val Leu Gln Lys 
    450                 455                 460                 


Glu Val Asn Gly Phe Gly Pro Leu Ser Lys Ile Glu Glu Leu Arg Asp 
465                 470                 475                 480 


Gly Asp Asn His Lys Gly Gln Tyr Ser Ser Ile Ile Arg Arg Val Ser 
                485                 490                 495     


Asn Asn Glu Lys Gln Leu Tyr Ser Pro Asp Thr Ala Asp Thr Lys Pro 
            500                 505                 510         


Tyr Leu Thr Asp His His Ala Ser Tyr Ala Ile Thr Gly Asn Arg Ile 
        515                 520                 525             


Gly Leu Met Trp Asp Thr Thr Arg Glu Asn Gly Val Leu Asn Pro Asp 
    530                 535                 540                 


Thr Leu Cys Tyr Leu Pro Lys Leu Pro Leu Pro Glu Leu Asn Pro Lys 
545                 550                 555                 560 


Asn Asn Ser Trp Ser Val Asp Lys Ser Val Ile Glu Ser Asn Ala Val 
                565                 570                 575     


Pro Arg Ala Trp Leu Ser Ile Tyr Asp Leu Pro Ala Leu Ile Phe Leu 
            580                 585                 590         


His Leu Leu Gly Gly Asn Pro Glu Lys Val Ile Lys Glu Lys Tyr Lys 
        595                 600                 605             


Asn Leu Lys Lys Leu Phe Asn Asp Ile Ala His Asn Lys Phe Lys Pro 
    610                 615                 620                 


Ile Phe Ser Gly Glu Val Glu Ser Lys Cys Val Lys Arg Lys Gln Gln 
625                 630                 635                 640 


Ile Glu Cys Leu Lys Lys Gln Leu Glu Leu Ile Leu Ala Glu Lys Tyr 
                645                 650                 655     


Lys Gly Val Glu Leu Lys Asp Ile Pro Ala Lys Leu Thr Glu Tyr Leu 
            660                 665                 670         


Thr Ile Gly Ala Val Ser Asn Cys Asp Ser Val Asp Val Gln Phe Thr 
        675                 680                 685             


Lys Trp Ile Arg His Gln Leu Asn Gly Tyr Pro Ser Gln Ile Asp Asn 
    690                 695                 700                 


Asn Gly His Val Ala Ile Arg Ala Tyr Lys Gly Leu Ile Ala Ser Leu 
705                 710                 715                 720 


Glu Asp Arg Ile Ala Lys Phe Asn Gln Asp Leu Lys Ile Ile Gly Asp 
                725                 730                 735     


Lys Gln Asn Arg Leu Gly Arg Lys Ser Tyr Val Asp Val Arg Pro Gly 
            740                 745                 750         


Ser Leu Ala Arg Tyr Leu Ser Lys Asp Ile Val Arg Met Thr Ile Ala 
        755                 760                 765             


Asp Asn Gly Lys Asp Asn Gly Gly Lys Pro Thr Gly Leu Asp Phe Ala 
    770                 775                 780                 


Val Leu Gln Ser Ser Ile Ala Thr Tyr Asn Asn Asn Asn Glu Ile Phe 
785                 790                 795                 800 


Lys Lys Thr Leu Leu Gly Gln Met Leu Gln His Ala Ile Pro Leu Glu 
                805                 810                 815     


Asn His Pro Phe Leu Cys Asn Met Met Gly Met Lys Ile Lys Asp Thr 
            820                 825                 830         


Ile Ser Phe Tyr Leu Thr Tyr Gln Lys Gln Lys Leu Lys Trp Leu Lys 
        835                 840                 845             


Lys Arg Ala Glu Lys Glu Asp Phe Leu Gln Asn Ala His Phe Met Tyr 
    850                 855                 860                 


Phe Met Arg Glu Ser Tyr Arg Asn Phe Leu Ala Thr Ser Pro Asp Leu 
865                 870                 875                 880 


Val Ile Ser Ser Asp Gly Asn Glu Asn His Val Lys Gly Leu Ala Glu 
                885                 890                 895     


Arg Tyr Leu Asp Thr Leu Tyr Leu Pro Asp Gly Leu Phe Thr Asn Ala 
            900                 905                 910         


Ile Arg Lys Gln Leu Ala Glu Asn Glu Asp Thr Arg Glu Asn Pro Phe 
        915                 920                 925             


Ile Val Ala Ala Leu Lys Asp Glu Ile Lys Gly His Ser Ala Ala Tyr 
    930                 935                 940                 


Leu Leu Asn Val Tyr Phe Thr His Val Leu Asn Asp Lys Ser Gln Thr 
945                 950                 955                 960 


Phe Tyr Arg Asn Gln Gly Asp Leu Tyr Lys Arg His Tyr Lys Leu Leu 
                965                 970                 975     


Asp Ile Leu Tyr Pro Asn Ser Lys Gly Tyr Leu Thr Glu Asn Asp Leu 
            980                 985                 990         


Ala Val Lys Leu Lys Lys Cys Asp  Gly Asn Gln Ser Asn  Ile Arg Lys 
        995                 1000                 1005             


Lys Ile  Asn Ser His Val Glu  Asn Leu Glu Ile Val  Val Lys Lys 
    1010                 1015                 1020             


Tyr Asp  Arg Ser Glu Gly Arg  Lys Val Ser Tyr Tyr  Ala Pro Ala 
    1025                 1030                 1035             


Asp Glu  Glu Thr Lys Asn Asn  Glu Arg Ile Lys Leu  Met His Gln 
    1040                 1045                 1050             


Leu Arg  Asp Leu Gln His Asn  Glu Gln Val Ile Arg  Arg Tyr Arg 
    1055                 1060                 1065             


Asn Glu  Asp Met Leu Leu Phe  Leu Met Ala Gln Lys  Leu Leu Leu 
    1070                 1075                 1080             


Lys Gly  Gly Phe Val Phe Lys  Asn Lys Ala Asp Ala  Gly Gly Met 
    1085                 1090                 1095             


Gln Lys  Phe Arg Leu Gln Asp  Ile Thr Pro Pro Ala  Tyr Asn Val 
    1100                 1105                 1110             


Asp Asn  Lys Lys Ser Leu Leu  Asp Ile Pro Ile Asp  Phe Ser Ile 
    1115                 1120                 1125             


Thr Phe  Gly Leu Asn Asp Glu  Asn Gly His Ile Ile  Thr Gly Glu 
    1130                 1135                 1140             


Asp Gly  Lys Gln Ile Lys Arg  Thr Ile Arg Gln Lys  Asp Ile Lys 
    1145                 1150                 1155             


Ile Lys  Asn Tyr Gly Asp Phe  Phe Ala Phe Leu Tyr  Asp Ser Arg 
    1160                 1165                 1170             


Ile Gly  Gly Leu Leu Ser Gln  Leu Pro Leu Ser Ser  Asp Asp Ile 
    1175                 1180                 1185             


Ile Glu  Arg Ser Asp Leu Asp  Lys Glu Leu Asp Ile  Tyr Asp Arg 
    1190                 1195                 1200             


Lys Arg  Leu Lys Val Phe Ala  Val Leu Gln Ala Ile  Glu Arg Lys 
    1205                 1210                 1215             


Ile Ile  Asn Glu His Pro Glu  Leu Ala Asp Thr Asn  Ala Gly Gly 
    1220                 1225                 1230             


Ile Gly  Phe Tyr Asp Glu Gly  Gly Lys Pro Tyr Arg  Asn Ser Phe 
    1235                 1240                 1245             


Ser Gly  Leu Leu Ser Leu Cys  Lys Gln Tyr Met Ala  Asn Glu Lys 
    1250                 1255                 1260             


Asp Leu  Asn Asp Met Gly Tyr  Gly Ile Val Asp Ile  Arg Asn Ala 
    1265                 1270                 1275             


Phe Ser  His Asn Arg Tyr Thr  Ser Asp Asn Asn Lys  His Ile Asn 
    1280                 1285                 1290             


Ile Ser  Lys Met Asn Leu Pro  Gln Val Ala Glu Leu  Ile Leu Lys 
    1295                 1300                 1305             


Trp Leu  Glu Lys Ala 
    1310             


<210>  1585
<211>  1148
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1585

Met Asn Ser Asn Phe Lys Ala Ser Gly Arg Pro Asn Gly Arg Ser Asn 
1               5                   10                  15      


Gly Phe Arg Gly Ala Gly Pro Val Lys Lys Arg Glu Tyr Leu Thr Gly 
            20                  25                  30          


Asp Phe Ala Arg Asp Met Lys Ser Leu Arg Ile Lys Gly Pro Val Arg 
        35                  40                  45              


Asn Pro Gln Thr Arg Lys Glu Ile Tyr Val Asp Glu Thr Pro Gln Phe 
    50                  55                  60                  


Ile Thr Tyr Leu Thr Leu Ala Leu Gln Asn Ile Ser Glu Ile Ile Gly 
65                  70                  75                  80  


Lys Gly Lys Asp Leu Ser Asn Phe Ser Asp Glu Ser Ser Val Lys Thr 
                85                  90                  95      


Ala Leu Glu Glu Ser Gly Arg Leu Phe Glu Val Ala Ser Phe Leu Trp 
            100                 105                 110         


Met Tyr Arg Val Glu Glu Pro Gly Arg Asp Tyr Asp Arg Ile Lys Lys 
        115                 120                 125             


Gly Glu Tyr Ala Asp Arg Ala Lys Glu Ile Val Val Ala Leu Trp Lys 
    130                 135                 140                 


Leu Arg Asn Met Phe Val His Pro Tyr Glu Lys Asn Ala Ala Lys Ala 
145                 150                 155                 160 


Leu Ile Val Ser Pro Glu Phe Tyr Arg Phe Ile Glu Gly Glu Leu Tyr 
                165                 170                 175     


Ser Glu Ala Arg Glu His Ala Leu Gly Pro Gly Arg Lys Ser Glu Lys 
            180                 185                 190         


Thr Phe Lys Leu Lys Leu Phe Asn Pro His Asp Asp Ala Arg Ala Thr 
        195                 200                 205             


Phe Glu Phe Thr Arg Lys Gly Leu Ile Phe Leu Thr Cys Leu Ala Leu 
    210                 215                 220                 


Tyr Arg His Asp Ala Ser Glu Phe Ile Gln Gln Phe Pro Asp Leu Gln 
225                 230                 235                 240 


Leu Pro Pro Arg Glu Trp Gln Val Glu Gln Gly Tyr Arg Ala Arg Pro 
                245                 250                 255     


Ser Glu Ser Glu Leu Val Glu Leu Arg Lys Lys Gly Gly Ala Val Lys 
            260                 265                 270         


Ser Ile Leu Asp Ala Phe Thr Trp Tyr Ser Met Arg Ala Ser Arg Thr 
        275                 280                 285             


Asp Ile Asp Val Val Asn Ser Asp Tyr Leu Asn Phe Ala Asn Ile Leu 
    290                 295                 300                 


Leu Tyr Leu Asn Lys Val Pro Ser Ala Ala Tyr Asn Tyr Leu Ser Leu 
305                 310                 315                 320 


Asp Glu Glu Ala Arg Arg Leu Ala Glu Lys Ala Ala Ala Ser Gln Glu 
                325                 330                 335     


Ser Glu Glu Asn Lys Arg Phe Arg Tyr Leu Leu Gln Glu Arg Lys Lys 
            340                 345                 350         


Asp Arg Phe Leu Thr Leu Ala Leu Ala Tyr Leu Glu Asp Phe His Arg 
        355                 360                 365             


Leu Asp Cys Ile Gly Phe Lys Arg Leu Asp Ile Thr Val Arg Pro Asp 
    370                 375                 380                 


Arg Lys Arg Tyr Met Phe Gly Pro Ile Pro Glu Gly Thr Val Asn Glu 
385                 390                 395                 400 


Arg Gly Glu Pro Leu Ser Asp Ala Asn Gly Met Asp Arg His Tyr Ala 
                405                 410                 415     


Ile Gln Asn Gly Ser Ala Gln Phe Glu Phe Val Pro Glu Gln His Tyr 
            420                 425                 430         


Gly Pro Ile Gln Ile Lys His Leu Arg Gly Ala Val Ser Glu Gly Glu 
        435                 440                 445             


Ile Met Arg Leu Leu Leu Val Met Phe Asp Asn Gly Ile Arg Arg Lys 
    450                 455                 460                 


Asn Pro Asn Asp Val Ile Lys Glu Tyr Leu Thr Ala Tyr His Arg Ile 
465                 470                 475                 480 


Leu Glu Arg Met Leu Asn Ala Gly Asp Thr Ser Ala Phe Thr Phe Asp 
                485                 490                 495     


Asp Pro Gln Tyr Arg Ala Asp Phe Lys Thr Val Ser Gly Lys Gly Asp 
            500                 505                 510         


Asp Val Phe Thr Lys Asp Arg Phe Val Gly Glu Met Lys Pro Phe Phe 
        515                 520                 525             


Ser Glu Asn Val Thr Arg Tyr Phe Val Gly Asn Glu Leu Arg Pro Ser 
    530                 535                 540                 


Pro Glu Ala Leu Gln Lys Lys Leu Val Lys Arg Phe Glu Ala Met Gln 
545                 550                 555                 560 


Gly Arg Ala Glu Asp Phe Leu Leu Lys Met Asp Arg Leu Thr Asp Trp 
                565                 570                 575     


Arg Lys Leu Asp Met Glu Ala Arg Lys Asp Lys Gly Phe Pro Val Cys 
            580                 585                 590         


Ala Ile Gly Glu Leu Lys Tyr Pro Pro Arg Thr Cys Lys Val Asn Asp 
        595                 600                 605             


Ala Gln Leu Val Lys Trp Val Leu Arg Tyr Ile Asn Leu Phe Leu Ala 
    610                 615                 620                 


Lys Glu Glu Lys Phe Arg Gln Leu Pro Arg Gly Leu Arg His Arg Gly 
625                 630                 635                 640 


Val Arg Asp Phe Glu Phe Gln Leu Leu His Thr Asp Ile Gly Arg Phe 
                645                 650                 655     


Gly Val Asn Pro Asp Ala Leu Trp Arg Thr Leu Glu Lys Arg Ser Ser 
            660                 665                 670         


Ile Asn Gly Glu Gly Gly Ala Leu Glu Met Leu Lys Asp Arg Glu Arg 
        675                 680                 685             


Lys Leu Phe Arg Ser Glu Gln Asp Arg Cys Arg Asp Lys Arg Asp Arg 
    690                 695                 700                 


Asn Gly Arg Pro Leu Arg Val Gly His Thr Leu Thr Met Leu Ala Thr 
705                 710                 715                 720 


Ala Ala Ala Glu Leu Tyr Arg Glu Ile Ser Glu Ser Phe Arg Ser Glu 
                725                 730                 735     


Tyr Ser Val Pro Leu Ser Asp Glu Asp Lys Asp Leu Leu Pro Tyr Val 
            740                 745                 750         


Cys Pro Thr Tyr Gly Val Arg Ala Gly Leu Pro Leu Asp Gln Lys Ser 
        755                 760                 765             


Leu Val Lys Thr Val Leu Gly Ile Asp Leu Asp Thr Trp Ser Arg Ala 
    770                 775                 780                 


Tyr Asp Tyr Ala Thr Gly Arg Asn Phe Glu Asn Arg Gln Leu Ala Asp 
785                 790                 795                 800 


Ala Arg Asp Leu Ile Val Thr Gln Val Pro Met Pro Asn Ala Phe Ala 
                805                 810                 815     


Ile Arg Cys Val Lys Pro Gly Glu Asn Gly Glu Pro Phe Lys Phe Asn 
            820                 825                 830         


Pro Glu Phe Arg Ala Phe Met Pro Tyr Glu Arg Gly Lys Met Ser Leu 
        835                 840                 845             


Arg Arg Tyr Tyr Asp Ala Ala Pro Leu Ile Val Ala Val Lys Arg Phe 
    850                 855                 860                 


Asp Glu Gln Ser Ser Leu Gly Met Gly Gly His Lys Arg Ala Asn Ala 
865                 870                 875                 880 


Glu Ile Arg Cys Ser Gly Thr Glu Gly Ile Glu Thr Arg Glu Trp Thr 
                885                 890                 895     


Asp Asp Gly Asp Ile Gly Ser Gly Lys Gly Pro Pro Arg Ser Arg Pro 
            900                 905                 910         


Ser Phe Ala Arg Gly Asp Val Asn Lys Ala Ile Gln Ala Ile Gln Leu 
        915                 920                 925             


Ala Glu Arg Gln Asp Lys Val Leu Leu Ala Cys Ala Lys Ala Tyr Trp 
    930                 935                 940                 


Asp Arg Tyr Met Gly Glu Glu Val Thr Ala Thr Gln Asn Glu Thr Gly 
945                 950                 955                 960 


Lys Lys Asp Gln Gln Lys Lys Asn Lys Ile Lys Asn Phe His Leu Ser 
                965                 970                 975     


Glu Ala Ala Asp Ile Gly Glu Phe Phe Ser Leu Pro Met Glu Asp Thr 
            980                 985                 990         


Val Asn Gly Val Lys Ile Arg Met  Met Pro Asn Asp Phe  Ala Arg Pro 
        995                 1000                 1005             


Ala Tyr  Gly Val Val Thr Thr  His Val Lys Glu Leu  Val Glu Asp 
    1010                 1015                 1020             


Ala Lys  Pro Leu Pro Gly Thr  Asp Gly Val Tyr Ser  Phe Tyr Asp 
    1025                 1030                 1035             


Leu Trp  Leu Ala Leu Arg Asn  Leu Gln His Glu Glu  Asn Arg Ile 
    1040                 1045                 1050             


Arg Leu  Asp Phe Leu Pro Ala  Ala Val Lys Phe Asn  Ala Cys Val 
    1055                 1060                 1065             


Asn Ile  Pro Pro Asp Leu Glu  Ser Leu Pro Asn Asp  Asp Pro Glu 
    1070                 1075                 1080             


Lys Ala  Pro Arg Ile Leu Ser  His Cys Asn Lys Ala  Leu Arg Ile 
    1085                 1090                 1095             


Arg Gly  Asn Val Lys Pro Leu  Ser Glu Glu Glu Tyr  Leu Leu Leu 
    1100                 1105                 1110             


Ala Arg  Phe Glu Pro Arg Leu  Arg His Pro Ala Ile  Lys Gly Leu 
    1115                 1120                 1125             


Asp Leu  Ile His Phe Asp Thr  Asp Ala Val Arg Ala  Ile Tyr Lys 
    1130                 1135                 1140             


Arg Phe  Gly Phe Met 
    1145             


<210>  1586
<211>  1214
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1586

Met Ser Ser Lys Asn Glu Ser Tyr Asn Lys Gln Lys Thr Phe Asn His 
1               5                   10                  15      


Tyr Lys Gln Glu Asp Lys Tyr Phe Phe Gly Gly Phe Leu Asn Asn Ala 
            20                  25                  30          


Asp Asp Asn Leu Arg Gln Val Gly Lys Glu Phe Lys Thr Arg Ile Asn 
        35                  40                  45              


Phe Asn His Asn Asn Asn Glu Leu Ala Ser Val Phe Lys Asp Tyr Phe 
    50                  55                  60                  


Asn Lys Glu Lys Ser Val Ala Lys Arg Glu His Ala Leu Asn Leu Leu 
65                  70                  75                  80  


Ser Asn Tyr Phe Pro Val Leu Glu Arg Ile Gln Lys His Thr Asn His 
                85                  90                  95      


Asn Phe Glu Gln Thr Arg Glu Ile Phe Glu Leu Leu Leu Asp Thr Ile 
            100                 105                 110         


Lys Lys Leu Arg Asp Tyr Tyr Thr His His Tyr His Lys Pro Ile Thr 
        115                 120                 125             


Ile Asn Pro Lys Ile Tyr Asp Phe Leu Asp Asp Thr Leu Leu Asp Val 
    130                 135                 140                 


Leu Ile Thr Ile Lys Lys Lys Lys Val Lys Asn Asp Thr Ser Arg Glu 
145                 150                 155                 160 


Leu Leu Lys Glu Lys Leu Arg Pro Glu Leu Thr Gln Leu Lys Asn Gln 
                165                 170                 175     


Lys Arg Glu Glu Leu Ile Lys Lys Gly Lys Lys Leu Leu Glu Glu Asn 
            180                 185                 190         


Leu Glu Asn Ala Val Phe Asn His Cys Leu Ile Pro Phe Leu Glu Glu 
        195                 200                 205             


Asn Lys Thr Asp Asp Lys Gln Asn Lys Thr Val Ser Leu Arg Lys Tyr 
    210                 215                 220                 


Arg Lys Ser Lys Pro Asn Glu Glu Thr Ser Ile Thr Leu Thr Gln Ser 
225                 230                 235                 240 


Gly Leu Val Phe Leu Met Ser Phe Phe Leu His Arg Lys Glu Phe Gln 
                245                 250                 255     


Val Phe Thr Ser Gly Leu Glu Arg Phe Lys Ala Lys Val Asn Thr Ile 
            260                 265                 270         


Lys Glu Glu Glu Ile Ser Leu Asn Lys Asn Asn Ile Val Tyr Met Ile 
        275                 280                 285             


Thr His Trp Ser Tyr Ser Tyr Tyr Asn Phe Lys Gly Leu Lys His Arg 
    290                 295                 300                 


Ile Lys Thr Asp Gln Gly Val Ser Thr Leu Glu Gln Asn Asn Thr Thr 
305                 310                 315                 320 


His Ser Leu Thr Asn Thr Asn Thr Lys Glu Ala Leu Leu Thr Gln Ile 
                325                 330                 335     


Val Asp Tyr Leu Ser Lys Val Pro Asn Glu Ile Tyr Glu Thr Leu Ser 
            340                 345                 350         


Glu Lys Gln Gln Lys Glu Phe Glu Glu Asp Ile Asn Glu Tyr Met Arg 
        355                 360                 365             


Glu Asn Pro Glu Asn Glu Asp Ser Thr Phe Ser Ser Ile Val Ser His 
    370                 375                 380                 


Lys Val Ile Arg Lys Arg Tyr Glu Asn Lys Phe Asn Tyr Phe Ala Met 
385                 390                 395                 400 


Arg Phe Leu Asp Glu Tyr Ala Glu Leu Pro Thr Leu Arg Phe Met Val 
                405                 410                 415     


Asn Phe Gly Asp Tyr Ile Lys Asp Arg Gln Lys Lys Ile Leu Glu Ser 
            420                 425                 430         


Ile Gln Phe Asp Ser Glu Arg Ile Ile Lys Lys Glu Ile His Leu Phe 
        435                 440                 445             


Glu Lys Leu Ser Leu Val Thr Glu Tyr Lys Lys Asn Val Tyr Leu Lys 
    450                 455                 460                 


Glu Thr Ser Asn Ile Asp Leu Ser Arg Phe Pro Leu Phe Pro Asn Pro 
465                 470                 475                 480 


Ser Tyr Val Met Ala Asn Asn Asn Ile Pro Phe Tyr Ile Asp Ser Arg 
                485                 490                 495     


Ser Asn Asn Leu Asp Glu Tyr Leu Asn Gln Lys Lys Lys Ala Gln Ser 
            500                 505                 510         


Gln Asn Lys Lys Arg Asn Leu Thr Phe Glu Lys Tyr Asn Lys Glu Gln 
        515                 520                 525             


Ser Lys Asp Ala Ile Ile Ala Met Leu Gln Lys Glu Ile Gly Val Lys 
    530                 535                 540                 


Asp Leu Gln Gln Arg Ser Thr Ile Gly Leu Leu Ser Cys Asn Glu Leu 
545                 550                 555                 560 


Pro Ser Met Leu Tyr Glu Val Ile Val Lys Asp Ile Lys Gly Ala Glu 
                565                 570                 575     


Leu Glu Asn Lys Ile Ala Gln Lys Ile Arg Glu Gln Tyr Gln Ser Ile 
            580                 585                 590         


Arg Asp Phe Thr Leu Asp Ser Pro Gln Lys Asp Asn Ile Pro Thr Thr 
        595                 600                 605             


Leu Ile Lys Thr Ile Asn Thr Asp Ser Ser Val Thr Phe Glu Asn Gln 
    610                 615                 620                 


Pro Ile Asp Ile Pro Arg Leu Lys Asn Ala Ile Gln Lys Glu Leu Ala 
625                 630                 635                 640 


Leu Thr Gln Glu Lys Leu Leu Asn Val Lys Glu His Glu Ile Glu Val 
                645                 650                 655     


Asp Asn Tyr Asn Arg Asn Lys Asn Thr Tyr Lys Phe Lys Asn Gln Pro 
            660                 665                 670         


Lys Asn Lys Val Asp Asp Lys Lys Leu Gln Arg Lys Tyr Val Phe Tyr 
        675                 680                 685             


Arg Asn Glu Ile Arg Gln Glu Ala Asn Trp Leu Ala Ser Asp Leu Ile 
    690                 695                 700                 


His Phe Met Lys Asn Lys Ser Leu Trp Lys Gly Tyr Met His Asn Glu 
705                 710                 715                 720 


Leu Gln Ser Phe Leu Ala Phe Phe Glu Asp Lys Lys Asn Asp Cys Ile 
                725                 730                 735     


Ala Leu Leu Glu Thr Val Phe Asn Leu Lys Glu Asp Cys Ile Leu Thr 
            740                 745                 750         


Lys Gly Leu Lys Asn Leu Phe Leu Lys His Gly Asn Phe Ile Asp Phe 
        755                 760                 765             


Tyr Lys Glu Tyr Leu Lys Leu Lys Glu Asp Phe Leu Asn Thr Glu Ser 
    770                 775                 780                 


Thr Phe Leu Glu Asn Gly Leu Ile Gly Leu Pro Pro Lys Ile Leu Lys 
785                 790                 795                 800 


Lys Glu Leu Ser Lys Arg Phe Lys Tyr Ile Phe Ile Val Phe Gln Lys 
                805                 810                 815     


Arg Gln Phe Ile Ile Lys Glu Leu Glu Glu Lys Lys Asn Asn Leu Tyr 
            820                 825                 830         


Ala Asp Ala Ile Asn Leu Ser Arg Gly Ile Phe Asp Glu Lys Pro Thr 
        835                 840                 845             


Met Ile Pro Phe Lys Lys Pro Asn Pro Asp Glu Phe Ala Ser Trp Phe 
    850                 855                 860                 


Val Ala Ser Tyr Gln Tyr Asn Asn Tyr Gln Ser Phe Tyr Glu Leu Thr 
865                 870                 875                 880 


Pro Asp Ile Val Glu Arg Asp Lys Lys Lys Lys Tyr Lys Asn Leu Arg 
                885                 890                 895     


Ala Ile Asn Lys Val Lys Ile Gln Asp Tyr Tyr Leu Lys Leu Met Val 
            900                 905                 910         


Asp Thr Leu Tyr Gln His Leu Phe Asn Gln Pro Leu Asp Lys Ser Leu 
        915                 920                 925             


Ser Asp Phe Tyr Val Ser Lys Ala Glu Arg Glu Lys Ile Lys Ala Asp 
    930                 935                 940                 


Ala Lys Ala Tyr Gln Lys Arg Asn Asp Ser Ser Leu Trp Asn Lys Val 
945                 950                 955                 960 


Ile His Leu Ser Leu Gln Asn Asn Arg Ile Thr Ala Asn Pro Lys Leu 
                965                 970                 975     


Lys Asp Ile Gly Lys Tyr Lys Arg Ala Leu Gln Asp Glu Lys Ile Ala 
            980                 985                 990         


Thr Leu Leu Thr Tyr Asp Ala Arg  Thr Trp Thr Tyr Ala  Leu Gln Lys 
        995                 1000                 1005             


Pro Glu  Lys Glu Asn Glu Asn  Asp Tyr Lys Glu Leu  His Tyr Thr 
    1010                 1015                 1020             


Ala Leu  Asn Met Glu Leu Gln  Glu Tyr Glu Lys Val  Arg Ser Lys 
    1025                 1030                 1035             


Glu Leu  Leu Lys Gln Val Gln  Glu Leu Glu Lys Lys  Ile Leu Asp 
    1040                 1045                 1050             


Lys Phe  Tyr Asp Phe Ser Asn  Asn Ala Ser His Pro  Glu Asp Leu 
    1055                 1060                 1065             


Glu Ile  Glu Asp Lys Lys Gly  Lys Arg His Pro Asn  Phe Lys Leu 
    1070                 1075                 1080             


Tyr Ile  Thr Lys Ala Leu Leu  Lys Asn Glu Ser Glu  Ile Ile Asn 
    1085                 1090                 1095             


Leu Glu  Asn Ile Asp Ile Glu  Ile Leu Leu Lys Tyr  Tyr Asp Tyr 
    1100                 1105                 1110             


Asn Thr  Glu Glu Leu Lys Glu  Lys Ile Lys Asn Met  Asp Glu Asp 
    1115                 1120                 1125             


Glu Lys  Ala Lys Ile Ile Asn  Thr Lys Glu Asn Tyr  Asn Lys Ile 
    1130                 1135                 1140             


Thr Asn  Val Leu Ile Lys Lys  Ala Leu Val Leu Ile  Ile Ile Arg 
    1145                 1150                 1155             


Asn Lys  Met Ala His Asn Gln  Tyr Pro Pro Lys Phe  Ile Tyr Asp 
    1160                 1165                 1170             


Leu Ala  Asn Arg Phe Val Pro  Lys Lys Glu Glu Glu  Tyr Phe Ala 
    1175                 1180                 1185             


Thr Tyr  Phe Asn Arg Val Phe  Glu Thr Ile Thr Lys  Glu Leu Trp 
    1190                 1195                 1200             


Glu Asn  Lys Glu Lys Lys Asp  Lys Thr Gln Val 
    1205                 1210                 


<210>  1587
<211>  1109
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1587

Met Glu Ser Glu Lys Gln Phe Arg Thr Ile Phe Asn Asn Lys Gly Asn 
1               5                   10                  15      


Ile Gly Pro Ile Ala Glu Lys Ala Lys Arg Asn Phe Asp Leu Ile Leu 
            20                  25                  30          


Lys Asn Glu His Ser Lys Thr Glu Arg Ile Tyr His Phe Cys Ile Gly 
        35                  40                  45              


His Thr Phe Lys Asn Ile Asp Lys Ser Ile Phe Glu Ser Lys Leu Asn 
    50                  55                  60                  


Glu Asn Leu Lys Lys Phe Gln Pro Thr Lys Tyr Ile Thr Leu Gln Lys 
65                  70                  75                  80  


Asp Phe Phe Thr Phe Glu Thr Glu Leu Tyr Glu Leu Ile Lys Arg Ile 
                85                  90                  95      


Arg Asp Cys Asn Ser His Tyr Val His Thr Phe Asp Lys Leu Ser Glu 
            100                 105                 110         


Glu Asn Ile Glu Lys Ser Asp Lys Ile Ile Pro Phe Ile Lys Asp Ala 
        115                 120                 125             


Phe Gln Phe Ser Ile Ile Ser Asn Tyr Ile Lys Glu Asn Asn Leu Ser 
    130                 135                 140                 


Phe Glu Lys Phe Asn Glu Asn Glu Asn Ser His Lys Glu Ile Val Lys 
145                 150                 155                 160 


Ser Ile Ile Asn Lys Phe Phe Pro Asn Gly Glu Met Gln Lys Asn Val 
                165                 170                 175     


Arg Asp Lys Phe Ser Lys Leu Asn Leu Lys Glu Val Ile Asp Glu Leu 
            180                 185                 190         


Leu Phe Ile Thr Val Asp Glu Asp Phe Glu Tyr Asn Leu Ile Glu Asn 
        195                 200                 205             


His Pro Ile Phe Thr Ile Lys Lys Gly Lys Tyr Leu Ser Asn Ile Ala 
    210                 215                 220                 


His Leu Phe Ile Leu Ser Leu Phe Leu Tyr Lys Asn Glu Ala Asn Gln 
225                 230                 235                 240 


Leu Ile Ser Lys Ile Arg Gly Phe Lys Arg Asn Asp Asp Glu Phe His 
                245                 250                 255     


His Lys Arg Asp Ile Phe Thr Phe Phe Ser Lys Lys Leu Thr Ser Gln 
            260                 265                 270         


Asp Ile Asn Asn Glu Glu Lys Asn Leu Ile Asn Phe Arg Asp Ile Ile 
        275                 280                 285             


Gln Tyr Leu Asn Lys Tyr Pro Thr Ala Trp Asn Lys Asn Ile Glu Pro 
    290                 295                 300                 


Glu Arg Gln Phe Thr Thr Met Thr Asn Ser Leu Glu Lys Tyr Val Ile 
305                 310                 315                 320 


Glu Thr Glu Ile Phe Arg Ser Phe Pro Thr Phe Lys Gly Lys Glu Glu 
                325                 330                 335     


His Asn Tyr Phe Leu Lys Tyr Val Ile Thr Asn Leu Phe Lys Lys Lys 
            340                 345                 350         


Lys His Leu Phe Asp Leu Asp Glu Tyr Lys Ile Ser Lys Glu Leu Glu 
        355                 360                 365             


Val Lys Leu His Gln Glu Tyr Tyr Leu Ser Pro Glu Leu Lys Asp Ala 
    370                 375                 380                 


Asn Phe Arg Leu Asp Gln Leu Lys Asn Lys Lys Asn Thr Asn Ser Phe 
385                 390                 395                 400 


Glu Glu Glu Lys Ile Glu Glu Glu Ile Glu Glu Leu Ser Glu Lys Glu 
                405                 410                 415     


Asn Ser Ile Leu Glu Lys Leu Lys Lys Arg Ile Lys Glu Asn Lys Leu 
            420                 425                 430         


Leu Met Ser Tyr Gly Arg Asn Gln Asp Arg Phe Met Glu Ile Ala Leu 
        435                 440                 445             


Arg Phe Leu Ala Glu Asn Asn Tyr Phe Gly Lys Asn Ala Lys Phe Lys 
    450                 455                 460                 


Leu Tyr Gln Phe Tyr Thr Thr Asp Glu Gln Ile Asp Tyr Leu Ala Lys 
465                 470                 475                 480 


Ala Lys Lys Glu Lys Thr Lys Lys Glu Tyr Asp Lys Ile Lys Tyr His 
                485                 490                 495     


Gln Gly Lys Val Val Asp Tyr Val Thr Tyr Lys Glu His Leu Lys Lys 
            500                 505                 510         


Tyr Pro Asp Trp Asp Phe Pro Phe Ala Ile Gln Asn Asn Ser Ile Gln 
        515                 520                 525             


Ile Lys Ile Gln Leu Thr Asn Lys Glu Trp Lys Leu Phe Ser Ile Gln 
    530                 535                 540                 


Arg Lys Leu Phe Ile Tyr Leu Leu Glu Asp Ala Leu Tyr Gly Asn Asp 
545                 550                 555                 560 


Lys Lys Ile Asp Asn Arg Gly Asn Ile Leu Leu Ser Asn Tyr Phe Leu 
                565                 570                 575     


Ser Asn Leu Ile Pro Glu Phe Asn Gln Leu Lys Asn Ser Leu Ala Asp 
            580                 585                 590         


Asp Ile Ile Thr Thr Glu His Arg Lys Leu Phe Pro Lys Arg Leu Leu 
        595                 600                 605             


Ala Lys Tyr Gln Glu Pro Ile Arg Asn Asn Thr Glu Gln Tyr Asn Pro 
    610                 615                 620                 


Phe Leu Glu Ile Leu Val Glu Thr Lys Lys Gln Glu Asn Arg Tyr Asp 
625                 630                 635                 640 


Asn Leu Phe Lys Lys Ser Lys Glu Leu Gly Leu Glu Asp Glu Phe Gln 
                645                 650                 655     


Lys Lys Asn Lys Gly Lys Gln Phe Lys Leu Arg Phe Leu His Lys Ala 
            660                 665                 670         


Trp Asn Leu Met Tyr Phe Arg Lys Ile Tyr Asp Lys Gln Val Glu Glu 
        675                 680                 685             


Asn Gly His His Lys Arg Phe Asn Ile Thr Lys Glu Glu Phe Asn Asp 
    690                 695                 700                 


Phe Cys Arg Trp Ile Phe Ala Phe Asp Glu Val Thr Glu Tyr Lys Lys 
705                 710                 715                 720 


Tyr Leu Glu Gln Leu Phe Thr Glu Lys Arg Phe Phe Asp Asp Glu Asp 
                725                 730                 735     


Phe Lys Thr Leu Phe Phe Ser Ser Asp Ser Leu Asn Glu Met Tyr Asn 
            740                 745                 750         


Lys Thr Lys Glu Asn Phe Gly Leu Trp Ile Asn Gly Arg Tyr Lys Lys 
        755                 760                 765             


Lys Glu Arg Lys Gly Asp Tyr Glu Lys Leu Leu Ala Lys Asp Ile Ile 
    770                 775                 780                 


Tyr Ile Asn Ile Ser His Phe Ile Asn Tyr Leu Lys Gln Lys Lys Lys 
785                 790                 795                 800 


Ile Thr Ile Glu Asn Glu Leu Ile Lys Tyr Ser Ala Ser Glu Asn Ile 
                805                 810                 815     


Pro Phe Leu Ile Asn Ser Phe Tyr Tyr Lys Glu Ile Leu Pro Lys Asp 
            820                 825                 830         


Glu Tyr Lys Glu Asn Gly Lys Leu Phe Asn Glu Leu Arg Thr Thr Lys 
        835                 840                 845             


Leu Glu Asp Ala Leu Leu Tyr Glu Ile Ala Met Gln Tyr Leu Lys Leu 
    850                 855                 860                 


Asp Lys Thr Ile Ile Asn Lys Ala Lys Glu Asn Val Thr Lys Ile Leu 
865                 870                 875                 880 


Thr Ser Thr Ile Glu Phe Asp Ile Lys Asp Ala Asn Asn Lys His Leu 
                885                 890                 895     


Tyr Asn Leu Val Val Pro Phe Ser Lys Ile Glu Asn Leu Ala Val Leu 
            900                 905                 910         


Phe Lys Leu Ile Ser Asn Ser Lys Asp Thr Phe Leu Thr Lys Ile Tyr 
        915                 920                 925             


Thr Ser Thr Lys Leu Leu Phe Pro Glu Leu Glu Tyr Glu Lys Glu Glu 
    930                 935                 940                 


Ser Asp Asn Lys Lys Ile Arg Glu Asn Leu Leu Glu Lys Lys Glu Leu 
945                 950                 955                 960 


Ser Phe Glu Ser Leu Asn Ala Ile Asn Asn Leu Ile Ile Ser Ser Ser 
                965                 970                 975     


Val Lys Val Ser Lys Val Phe Met Ala Leu Glu Lys Tyr Phe Ile Ile 
            980                 985                 990         


Lys Ile Asp Thr Lys Ile Pro Tyr  Gly Lys Asp Tyr Val  Asn Val Tyr 
        995                 1000                 1005             


Asp Ile  His Leu Asp Asn Asn  Asn Thr Phe Glu Asn  Glu Tyr Asn 
    1010                 1015                 1020             


Glu Asn  Asp Thr Arg Asn Asn  Val Ala His Phe Asp  Ile Pro Lys 
    1025                 1030                 1035             


Ile Asn  Tyr Asp Ile Phe Ile  Lys Asn Ile Glu Ala  Lys Phe Ile 
    1040                 1045                 1050             


Thr Asn  Glu Ile Lys Pro Leu  Lys Ala Lys Ser Phe  Glu Asp Leu 
    1055                 1060                 1065             


Asn Gln  Asn Ile Lys Asp Val  Cys Ser Ile Phe Leu  Asn Ile Leu 
    1070                 1075                 1080             


His Ser  Asn Leu Tyr Pro Arg  Gly Lys Gly Asn Lys  Lys Thr Glu 
    1085                 1090                 1095             


Met Glu  Gln Lys Tyr Phe Asn  Gln Ser Leu Lys 
    1100                 1105                 


<210>  1588
<211>  1199
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1588

Met Asn Thr Phe Ile Asp Ser Phe Ile Arg Arg Val Gln Ile Gln Asn 
1               5                   10                  15      


Gln Asn Gln Ser Trp Pro Lys Arg Pro Lys Tyr Val Arg Pro Val Glu 
            20                  25                  30          


Asn Ile Arg Pro Asp Asp Leu Ala Phe Gln Ser His Phe Thr Ala Tyr 
        35                  40                  45              


Leu Asn Met Ala Arg Gln Asn Cys Cys Ile Ile Leu Gly His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Gly Phe Lys Ala Ser Ser Val Lys Asp Thr Thr Leu Thr 
65                  70                  75                  80  


Ser Ser Pro Leu Leu Gly Gln Asn Gly Leu Leu Ser Pro Lys Lys Glu 
                85                  90                  95      


Val Ser Asp Leu Ile Arg Gly Arg Leu Leu Ser Ala Phe Pro Met Leu 
            100                 105                 110         


Asp Pro Met Ile Arg Tyr Arg Lys Ala Val Asp Lys Glu Lys Asp Asp 
        115                 120                 125             


Tyr Ala Arg Ile Ile Ile Thr Ser Glu Asp Val Ser Glu Met Leu Arg 
    130                 135                 140                 


Asp Leu Leu Asp Val Leu Ser Tyr Tyr Arg Asp Met Ala Ser His Val 
145                 150                 155                 160 


Val Phe Asn Asp Asp Arg Ser Val Ser Ala Glu Phe Ala Ser Lys Glu 
                165                 170                 175     


Lys Lys Val Ala Glu Cys Leu Asn Tyr Met Met Thr Val Ser Leu Arg 
            180                 185                 190         


Ile Val Lys Asp Arg Phe Ser Leu Ala Val Ser Asp Leu Asp Phe Tyr 
        195                 200                 205             


Asn Arg Asn Arg Tyr Met Met Val Asn Arg Lys Pro Leu Leu Asn Ala 
    210                 215                 220                 


Gly Phe Ala His Ala Val Arg Thr Glu Asp Tyr Arg Leu Thr Leu Met 
225                 230                 235                 240 


Gly Leu Val Leu Leu Cys Cys Gln Phe Ile Glu Lys Gln Tyr Ala Ser 
                245                 250                 255     


Met Phe Phe Asp Ala Leu Asp Lys His Ser Asn Gly Ala Arg Phe Tyr 
            260                 265                 270         


Gly Ile Ala Asp Ala Met Pro Met Val Asn Val Gly Thr Lys Asp Lys 
        275                 280                 285             


Pro Lys Lys Ile Pro Met Tyr Thr Gly Asp Glu Ala Gln Lys Gln Val 
    290                 295                 300                 


Gln Lys Gln Arg Met Ala Leu Arg Glu Ala Tyr Ser Val Tyr Arg Val 
305                 310                 315                 320 


Arg Ile Pro Lys Glu Arg Leu Glu Ser Thr Arg Ser Asp Met Ala Leu 
                325                 330                 335     


Ala Leu Asp Ile Leu Asn Glu Leu Gly Lys Cys Pro Glu Glu Leu Phe 
            340                 345                 350         


Glu His Leu Ser Pro Glu Asp Arg Glu Ser Phe Lys Asn Glu Glu Gly 
        355                 360                 365             


Val Leu Met Lys Arg Tyr Ser Asp Arg Phe Pro Gln Leu Ala Leu Arg 
    370                 375                 380                 


Trp Leu Asp Glu Asn Glu Lys Phe Asn Asn Leu Arg Phe His Val Thr 
385                 390                 395                 400 


Phe Gly Lys Tyr Arg Trp Leu Phe Cys Gln Asp Lys Lys Cys Ala Asp 
                405                 410                 415     


Gly Ser Val Arg Pro Arg Trp Leu Gln Lys Glu Leu Asn Gly Phe Gly 
            420                 425                 430         


Arg Ile Gln Thr Val Glu Arg Lys Arg Thr Gly Leu Glu Pro Gly Trp 
        435                 440                 445             


Asp Gly Thr Gly Leu Ile Arg Lys Phe Glu Glu Val Val Thr Asp Glu 
    450                 455                 460                 


Val Gln Lys Glu Pro Tyr Ile Thr Asp Phe Arg Thr Gln Tyr Leu Phe 
465                 470                 475                 480 


Asn Arg Asp Lys Ile Gly Ile Ser Leu Ser Glu Tyr Met Pro Gly Ile 
                485                 490                 495     


Gly Asp Ile His Ser Gly Lys Glu Trp Gly Lys His Ala Gly Val Pro 
            500                 505                 510         


Asp Phe Tyr Leu Ser Val Tyr Asp Ile Pro Ala Met Leu Phe Leu Thr 
        515                 520                 525             


Trp Leu Leu Gly Lys Asn Ser Ser Ala Val Glu Lys Leu Leu Ala Asn 
    530                 535                 540                 


Cys Lys Ala Ala Tyr Met Lys Leu Phe Asp Asp Leu Ala Lys Gly Lys 
545                 550                 555                 560 


Trp Glu Gly Glu Arg Asn Val Ser Asp Tyr Cys Ala Gly Glu Gly Thr 
                565                 570                 575     


Val Arg Tyr Thr Leu Arg Trp Tyr Asp Val Pro Met Lys Ile Arg Arg 
            580                 585                 590         


Lys Met Pro Leu Leu Gly Gly Asp Arg Asp Phe Glu Glu Lys Lys Ser 
        595                 600                 605             


Phe Glu Thr Leu Ala Gln Glu Ala Leu Thr Arg Met Leu Gln Arg Thr 
    610                 615                 620                 


Glu Asn Gln Leu Glu Lys Phe Asp Arg Asp Leu Ala Ala Ala Arg Asp 
625                 630                 635                 640 


Leu Lys Ala Asn Lys Gln Gly Lys Asp Arg Phe Val Asp Ile Arg Ala 
                645                 650                 655     


Gly Ser Leu Ala Thr Phe Leu Ala Arg Asp Ile Val Arg Leu Met Pro 
            660                 665                 670         


Val Ser Asp Asn Gly Arg Asn Lys Pro Thr Gly Leu Asn Tyr Ser Ile 
        675                 680                 685             


Val Gln Lys Ala Ile Ala Thr Tyr Lys Pro Ser Glu Gly Gly Leu Asp 
    690                 695                 700                 


Thr Leu Thr Gly Val Phe Arg Asp Ala Arg Ile Ile Gly Val Lys Gly 
705                 710                 715                 720 


Gly Ser His Pro Phe Leu Glu Arg Leu Leu Val Glu Lys Lys Pro Ser 
                725                 730                 735     


Ser Val Leu Ala Leu Tyr Arg His Tyr Leu Glu Tyr Arg Lys Glu Tyr 
            740                 745                 750         


Leu Lys Lys Ala Leu Glu Asp Glu Asn Lys Ala Glu Leu Lys Asn Leu 
        755                 760                 765             


Pro Phe Leu Lys Ser Gly Arg Gln Lys Tyr Ala Val Asp Gln Ala Asp 
    770                 775                 780                 


Tyr Ala Arg Arg Leu Ala Glu Ser Tyr Arg Asn Cys Pro Ile Tyr Leu 
785                 790                 795                 800 


Pro Thr Gly Ile Phe Thr Asp Met Leu Lys Asp Gln Leu Ala Lys Ile 
                805                 810                 815     


Asp Val Met Lys Pro Val Leu Glu Asn Asp Lys Val Asn Ala Ser Tyr 
            820                 825                 830         


Leu Ile Ala Gln Tyr Phe Glu Lys Val Glu His Asp Ser Glu Gln Pro 
        835                 840                 845             


Leu Tyr Arg Leu Lys Arg Asn Tyr Arg Val Phe Asp Leu Leu Glu Phe 
    850                 855                 860                 


Thr Asp Glu Pro Lys Tyr Trp Arg Leu Asn Glu Arg Ser Asp Lys Ala 
865                 870                 875                 880 


Gly Lys Tyr Gly Leu Ala Lys Arg Asn Ile Phe Trp Asn Arg Met Gly 
                885                 890                 895     


Glu Tyr Tyr Lys Gly Leu Lys Lys Phe Tyr Lys Gly Tyr Glu Ser Lys 
            900                 905                 910         


Arg Thr Ala Val Asp Trp Arg Glu Lys Leu Lys Ile Val Glu Ala Glu 
        915                 920                 925             


His Ala Met Trp Asn Arg Leu Lys Asp Ala Ser Gly Glu Ala Arg Leu 
    930                 935                 940                 


Lys Met Lys Asp Gly Val Phe Tyr Ser Arg Leu Leu Ser Ala Arg Lys 
945                 950                 955                 960 


Glu Tyr Asp Asp Cys Glu Arg Ala Leu Arg Arg Leu Lys Val Gln Asp 
                965                 970                 975     


Ile Val Leu Phe Leu Ala Ala Arg Glu Thr Leu Ile Leu Pro Lys Asp 
            980                 985                 990         


Lys Val Phe Arg Leu Lys Asn Leu  Ser Leu Ser Glu Gly  Asn Lys Asn 
        995                 1000                 1005             


Ile Leu  Ser Ser Ala Ile Asp  Glu Phe Ser Val Asp  Val Val Trp 
    1010                 1015                 1020             


Thr Glu  Lys Glu Gly Ala Ala  Lys Val Thr His Ser  Ala Ser Ile 
    1025                 1030                 1035             


Lys Glu  Asn Asp Val Val Ile  Lys Asn Tyr Gly Arg  Met Phe Arg 
    1040                 1045                 1050             


Leu Leu  His Asp Asp Arg Val  Lys Thr Leu Leu Pro  His Ile Tyr 
    1055                 1060                 1065             


Asp Ser  Ala Leu Ser Glu Asn  Ile Thr Gly Asp Arg  Ile Thr Val 
    1070                 1075                 1080             


Lys Asp  Asn Lys Val Ile Ile  Asp Lys Ser Leu Phe  Asp Glu Asp 
    1085                 1090                 1095             


Leu Met  Asn Tyr Asp Leu Arg  Arg His Glu Ile Cys  Glu Ile Ile 
    1100                 1105                 1110             


Leu Arg  Phe Glu Ala Ala Ser  Ile Lys Arg Phe Gly  Leu Asp Gly 
    1115                 1120                 1125             


Arg Val  Asp Phe Lys Ala Ala  Leu Asp Ala Leu Thr  Gly Arg Ser 
    1130                 1135                 1140             


Leu Leu  Asn Asp Glu Asp Ala  Arg Ile Leu Ser Ala  Ile Arg Asn 
    1145                 1150                 1155             


Ala Tyr  Asn His Asn Lys Tyr  Pro Ala Lys Gly Thr  Asp Val Lys 
    1160                 1165                 1170             


Val Asn  Val Met Ala Leu Pro  Lys Leu Thr Glu Asp  Leu Leu Arg 
    1175                 1180                 1185             


Ile Phe  Ser Asp Thr Gly Asn  Asn Arg Val Arg 
    1190                 1195                 


<210>  1589
<211>  1215
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1589

Met Asp Tyr Thr Ala Lys Ser Asp Phe Lys Lys Ile Phe Glu Asn Lys 
1               5                   10                  15      


Gly Tyr Val Gly Ala Leu Ala Glu Lys Ser Ser Asn Asn Phe Glu Tyr 
            20                  25                  30          


Ile Tyr Lys Asn Thr Val Asn Arg Asn Ser Arg Leu Phe Tyr Phe Ala 
        35                  40                  45              


Val Gly His Lys Phe Lys Asn Leu Pro Val Pro Ala Ser Ile Leu Phe 
    50                  55                  60                  


Arg Lys Glu Tyr Asp Glu Gln Thr Gly Asp Phe Arg Cys Asn Asp Phe 
65                  70                  75                  80  


Thr Tyr Leu Gln Glu Lys Asn Phe Arg Asp Val Asn Gly Glu Asp Leu 
                85                  90                  95      


Leu Lys Glu Thr Ile Arg Gly Ile Arg Asn Leu Asn Ser His Tyr Val 
            100                 105                 110         


His Leu Phe Asp Pro Leu Ile Ile Asp Asn Lys Ser Lys Pro Val Ala 
        115                 120                 125             


Leu Phe Leu Lys Asp Ala Phe Arg Met Ala Thr Leu Val Gln Phe Leu 
    130                 135                 140                 


Asp Arg Glu Asp Ala Trp Lys Arg Leu Trp Lys Glu Ala Gly Ser Ala 
145                 150                 155                 160 


Phe Pro Glu Gly Asp Tyr Ser Ala Glu Gln Ile Asn Pro Lys Leu Leu 
                165                 170                 175     


Glu Lys Tyr Val Arg Tyr Ile Ser Asn Ser Ser Phe Lys Ala Arg Tyr 
            180                 185                 190         


Lys Gln Phe Leu Tyr Glu Lys Phe Arg Gln Asp Lys Lys Lys Gln Gly 
        195                 200                 205             


Ser Arg Ala Asn Gly Asp Gly Ala Ser Ser Ser Asn Ala Ser Gly Phe 
    210                 215                 220                 


Pro Glu Glu Trp Ser Ile Asp Ala Cys Leu Asp Asn Leu Leu Phe Thr 
225                 230                 235                 240 


Glu Val Gln Gln Glu Ile Glu Trp Lys Leu Tyr Asn Lys Tyr Pro Ile 
                245                 250                 255     


Ile Asn Ile Gly Val Gly Thr Tyr Ile Ser Phe Ile Gly Met Leu Phe 
            260                 265                 270         


Leu Leu Ser Met Phe Leu Tyr Lys Asp Glu Ala Asp Leu Leu Ile Ser 
        275                 280                 285             


Lys Ile Ser Gly Tyr Lys Lys Asn Asp Asp Asp Glu Met Arg Cys Lys 
    290                 295                 300                 


Arg Asn Ile Met Ser Phe Phe Ser Lys Lys Leu Ser Ser Gln Asp Tyr 
305                 310                 315                 320 


Asp Ser Glu Glu Lys His Leu Ile Tyr Phe Arg Asp Ile Ile Gln Tyr 
                325                 330                 335     


Leu Asn Lys Tyr Pro Thr Glu Trp Asn Lys Lys Val Asp Leu Asp Asn 
            340                 345                 350         


Glu Thr Asp Ser Leu Phe Ser Ala Ala Leu Lys Gln Lys Ile Glu Glu 
        355                 360                 365             


Met Glu Ile Asn Arg Leu Phe Pro Tyr Met Arg Asp Asp Val Asp Phe 
    370                 375                 380                 


Lys His Phe Ala Val Glu Arg Leu Phe Arg Lys Lys His Val Glu Pro 
385                 390                 395                 400 


Leu Lys Pro Ile Tyr Ser Ala Leu Ile Glu Lys Asn Glu Leu Leu Gly 
                405                 410                 415     


Thr Ile Tyr Arg Gln Val Glu Ser His Asn Leu Leu Gly Gly Glu Tyr 
            420                 425                 430         


Lys Gly Phe Glu Phe Lys Glu Tyr Val Leu Gln Tyr Val Leu Asn Thr 
        435                 440                 445             


Phe Phe Pro Gly Lys Thr Asp Trp Ser Glu Tyr Arg Asn Lys Thr Phe 
    450                 455                 460                 


Glu Lys Glu Glu Thr His Glu Ala Lys Leu Asn Thr Asn Lys Glu Val 
465                 470                 475                 480 


Ala Lys Leu Lys Glu Arg Leu Lys Gln Lys Leu Phe Tyr Thr Ser Tyr 
                485                 490                 495     


Gly Arg Asn Gln Asp Arg Phe Met Glu Met Ala Ile Arg Tyr Leu Ala 
            500                 505                 510         


Thr Glu Glu Tyr Phe Gly Lys Asp Ala Lys Phe Lys Met Tyr Lys Phe 
        515                 520                 525             


Lys Thr Val Glu Glu Gln Thr Asp Tyr Leu Glu Ala Val Glu Asn Asp 
    530                 535                 540                 


Lys Ser Met Ser Lys Gln Glu Leu Asp Lys Gln Lys Phe His Asn Gly 
545                 550                 555                 560 


Lys Leu Thr Tyr Tyr Ala Thr Tyr Ser Glu His Cys Lys Lys Tyr Pro 
                565                 570                 575     


Glu Trp Asp Met Pro Phe Val Ile Glu Asn Asn Ser Phe Lys Val Gln 
            580                 585                 590         


Leu Lys Leu Ser Gln Thr Glu Ile Ser Glu Thr Glu Val Ser Ile Gln 
        595                 600                 605             


Arg Ser Leu Leu Val Tyr Leu Leu Gln Asp Cys Leu Phe Pro Pro Glu 
    610                 615                 620                 


Gly Pro Asn Lys Thr Ser Gly Glu Ser Leu Phe Gln Glu Tyr Tyr Lys 
625                 630                 635                 640 


Gly Tyr Lys Asp Arg Leu Glu Thr Ala Cys Gln Ala Phe Glu Asn Lys 
                645                 650                 655     


Ser Val Glu Gln Leu Thr Ser Ile Lys Lys Leu Leu Pro Arg Arg Ala 
            660                 665                 670         


Val Lys Arg Gln Phe Ser Asp Glu Pro Met Gln Gln Pro Thr His Thr 
        675                 680                 685             


Leu Tyr Lys Ile Leu Glu Glu Ala Arg Arg Gln Glu Glu Arg Tyr Glu 
    690                 695                 700                 


Gln Leu Leu Ala Tyr Lys Arg Ala Thr Ala Arg Ser Ile Gln Ser Ser 
705                 710                 715                 720 


Glu Val Tyr Asp His Phe Ile His Lys Asn Lys Gly Lys Gln Phe Lys 
                725                 730                 735     


Leu Arg Phe Ile Arg Lys Ala Trp Asn Leu Met Tyr Phe Lys Asp Ile 
            740                 745                 750         


Tyr Lys Asn Ser Leu Ser Thr Cys Gly Gln His His Lys Ser Phe His 
        755                 760                 765             


Ile Thr Arg Asp Glu Tyr Asn Asp Phe Cys Arg Tyr Leu Phe Ala Met 
    770                 775                 780                 


Asp Thr Val Pro Asp Tyr Lys Ser Arg Leu Arg Met Leu Leu Asp Gln 
785                 790                 795                 800 


Lys Ser Phe Phe Ala Asp Lys Ala Phe Glu Arg Leu Phe Asn Glu Gly 
                805                 810                 815     


His Ser Leu Asp Glu Tyr Tyr Arg Lys Thr Lys Val Leu Phe Lys Glu 
            820                 825                 830         


Trp Ala Asp Lys Gln Gln Ser Val Ala Val Pro Glu Glu Lys Tyr Arg 
        835                 840                 845             


Leu Lys Asn Tyr Lys Asn Phe Ser Glu Lys Ala Ile Leu Tyr Ile Asn 
    850                 855                 860                 


Leu Ser Asp Phe Ile Ala Phe Leu Ile Glu Lys Lys Arg Leu Gln Thr 
865                 870                 875                 880 


Asn Ala Glu His Lys Leu Cys Leu Pro Ala Leu Arg Asn Ile Glu His 
                885                 890                 895     


Leu Ile Pro Gly Phe Tyr Ser Val Glu Gly Glu Thr Thr Ser Arg Ser 
            900                 905                 910         


Met Cys Lys Lys Leu Met Ala Asn Arg Leu Glu Asp Cys Leu Leu Tyr 
        915                 920                 925             


Glu Leu Ala Ile Cys Tyr Leu Gln Lys Glu Lys Glu Lys Glu Lys Glu 
    930                 935                 940                 


Lys Glu Lys Lys Lys Glu Ile Lys Gln Leu Asn Arg Arg Gly Val Asp 
945                 950                 955                 960 


Val Ile Leu Asn Thr Asn Gln Val Leu Thr Ile Glu Ile Lys Pro Asp 
                965                 970                 975     


Lys Gly Lys Thr Lys Pro Asp Lys Asp Lys Thr Gln Gly Glu Val Tyr 
            980                 985                 990         


Tyr Ile Glu Met Pro Phe Asn His  Ile Glu Lys Tyr Val  Gly Ile Val 
        995                 1000                 1005             


Ser Leu  Lys Ile Lys Lys Glu  Glu Lys Gly His Arg  Ser Phe Leu 
    1010                 1015                 1020             


Ser Asp  Leu Pro Gly Tyr Ile  Lys Leu Val Asn Asp  Lys Leu Val 
    1025                 1030                 1035             


Asn Glu  Lys Asn Arg Pro Asn  Gly Arg Gly Ser Lys  Glu Leu Glu 
    1040                 1045                 1050             


Arg Ile  Ser Arg Ile Tyr Gln  Asn Tyr Leu Glu Arg  Gly Asn Lys 
    1055                 1060                 1065             


Ile Leu  Leu Glu Glu Tyr Asn  Ser Ile Gln Arg His  Ile Val Thr 
    1070                 1075                 1080             


Glu Ala  Gly Lys Phe Ile Ser  Leu Tyr Met Glu Leu  Glu Lys Tyr 
    1085                 1090                 1095             


Phe Ile  Tyr Asn Asn Lys Met  Gln Leu Leu Ile Ile  Glu Gly Glu 
    1100                 1105                 1110             


Arg Asn  Arg Ile Thr Phe Glu  Glu Ile Pro Glu Leu  Lys Ala Leu 
    1115                 1120                 1125             


Val Gly  Arg Glu Arg Arg Asn  Thr Ala Phe His Phe  Gly Ile Pro 
    1130                 1135                 1140             


Lys Gly  Lys Leu Tyr Thr Glu  Ile Met Lys Asp Ile  Glu Asn Gly 
    1145                 1150                 1155             


Val Ile  Glu Gln Ile Val Lys  Pro Met Asn Cys Lys  Asp Tyr Arg 
    1160                 1165                 1170             


Ser Ile  Pro Asp Glu Lys Arg  Ala Val Leu Asp Lys  Leu Tyr Glu 
    1175                 1180                 1185             


Cys Gln  Lys Lys Asp Gly Lys  Pro Lys Lys Arg Ser  Ile Asp Glu 
    1190                 1195                 1200             


Glu Asn  Arg Tyr Phe Glu Lys  Met Ile Arg Lys Lys  
    1205                 1210                 1215 


<210>  1590
<211>  1184
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1590

Met Glu Arg Ile Phe Gly His Cys Cys Pro His His Asp Ser Val Cys 
1               5                   10                  15      


Phe Val Arg Phe Leu Gly Thr Met Val Ser Asn Gln Asp Gly Arg Glu 
            20                  25                  30          


Asn Val Leu Asp Ile Leu Tyr Ile Ala Asp Arg Thr Arg Lys Leu Lys 
        35                  40                  45              


Pro Met Asn Thr Val Pro Ala Ser Glu Asn Lys Gly Gln Ser Arg Thr 
    50                  55                  60                  


Val Glu Asp Asp Pro Gln Tyr Phe Gly Leu Tyr Leu Asn Leu Ala Arg 
65                  70                  75                  80  


Glu Asn Leu Ile Glu Val Glu Ser His Val Arg Ile Lys Phe Gly Lys 
                85                  90                  95      


Lys Lys Leu Asn Glu Glu Ser Leu Lys Gln Ser Leu Leu Cys Asp His 
            100                 105                 110         


Leu Leu Ser Val Asp Arg Trp Thr Lys Val Tyr Gly His Ser Arg Arg 
        115                 120                 125             


Tyr Leu Pro Phe Leu His Tyr Phe Asp Pro Asp Ser Gln Ile Glu Lys 
    130                 135                 140                 


Asp His Asp Ser Lys Thr Gly Val Asp Pro Asp Ser Ala Gln Arg Leu 
145                 150                 155                 160 


Ile Arg Glu Leu Tyr Ser Leu Leu Asp Phe Leu Arg Asn Asp Phe Ser 
                165                 170                 175     


His Asn Arg Leu Asp Gly Thr Thr Phe Glu His Leu Glu Val Ser Pro 
            180                 185                 190         


Asp Ile Ser Ser Phe Ile Thr Gly Thr Tyr Ser Leu Ala Cys Gly Arg 
        195                 200                 205             


Ala Gln Ser Arg Phe Ala Val Phe Phe Lys Pro Asp Asp Phe Val Leu 
    210                 215                 220                 


Ala Lys Asn Arg Lys Glu Gln Leu Ile Ser Val Ala Asp Gly Lys Glu 
225                 230                 235                 240 


Cys Leu Thr Val Ser Gly Phe Ala Phe Phe Ile Cys Leu Phe Leu Asp 
                245                 250                 255     


Arg Glu Gln Ala Ser Gly Met Leu Ser Arg Ile Arg Gly Phe Lys Arg 
            260                 265                 270         


Thr Asp Glu Asn Trp Ala Arg Ala Val His Glu Thr Phe Cys Asp Leu 
        275                 280                 285             


Cys Ile Arg His Pro His Asp Arg Leu Glu Ser Ser Asn Thr Lys Glu 
    290                 295                 300                 


Ala Leu Leu Leu Asp Met Leu Asn Glu Leu Asn Arg Cys Pro Arg Ile 
305                 310                 315                 320 


Leu Tyr Asp Met Leu Pro Glu Glu Glu Arg Ala Gln Phe Leu Pro Ala 
                325                 330                 335     


Leu Asp Glu Asn Ser Met Asn Asn Leu Ser Glu Asn Ser Leu Asp Glu 
            340                 345                 350         


Glu Ser Arg Leu Leu Trp Asp Gly Ser Ser Asp Trp Ala Glu Ala Leu 
        355                 360                 365             


Thr Lys Arg Ile Arg His Gln Asp Arg Phe Pro Tyr Leu Met Leu Arg 
    370                 375                 380                 


Phe Ile Glu Glu Met Asp Leu Leu Lys Gly Ile Arg Phe Arg Val Asp 
385                 390                 395                 400 


Leu Gly Glu Ile Glu Leu Asp Ser Tyr Ser Lys Lys Val Gly Arg Asn 
                405                 410                 415     


Gly Glu Tyr Asp Arg Thr Ile Thr Asp His Ala Leu Ala Phe Gly Lys 
            420                 425                 430         


Leu Ser Asp Phe Gln Asn Glu Glu Glu Val Ser Arg Met Ile Ser Gly 
        435                 440                 445             


Glu Ala Ser Tyr Pro Val Arg Phe Ser Leu Phe Ala Pro Arg Tyr Ala 
    450                 455                 460                 


Ile Tyr Asp Asn Lys Ile Gly Tyr Cys His Thr Ser Asp Pro Val Tyr 
465                 470                 475                 480 


Pro Lys Ser Lys Thr Gly Glu Lys Arg Ala Leu Ser Asn Pro Gln Ser 
                485                 490                 495     


Met Gly Phe Ile Ser Val His Asp Leu Arg Lys Leu Leu Leu Met Glu 
            500                 505                 510         


Leu Leu Cys Glu Gly Ser Phe Ser Arg Met Gln Ser Asp Phe Leu Arg 
        515                 520                 525             


Lys Ala Asn Arg Ile Leu Asp Glu Thr Ala Glu Gly Lys Leu Gln Phe 
    530                 535                 540                 


Ser Ala Leu Phe Pro Glu Met Arg His Arg Phe Ile Pro Pro Gln Asn 
545                 550                 555                 560 


Pro Lys Ser Lys Asp Arg Arg Glu Lys Ala Glu Thr Thr Leu Glu Lys 
                565                 570                 575     


Tyr Lys Gln Glu Ile Lys Gly Arg Lys Asp Lys Leu Asn Ser Gln Leu 
            580                 585                 590         


Leu Ser Ala Phe Asp Met Asp Gln Arg Gln Leu Pro Ser Arg Leu Leu 
        595                 600                 605             


Asp Glu Trp Met Asn Ile Arg Pro Ala Ser His Ser Val Lys Leu Arg 
    610                 615                 620                 


Thr Tyr Val Lys Gln Leu Asn Glu Asp Cys Arg Leu Arg Leu Arg Lys 
625                 630                 635                 640 


Phe Arg Lys Asp Gly Asp Gly Lys Ala Arg Ala Ile Pro Leu Val Gly 
                645                 650                 655     


Glu Met Ala Thr Phe Leu Ser Gln Asp Ile Val Arg Met Ile Ile Ser 
            660                 665                 670         


Glu Glu Thr Lys Lys Leu Ile Thr Ser Ala Tyr Tyr Asn Glu Met Gln 
        675                 680                 685             


Arg Ser Leu Ala Gln Tyr Ala Gly Glu Glu Asn Arg Arg Gln Phe Arg 
    690                 695                 700                 


Ala Ile Val Ala Glu Leu Arg Leu Leu Asp Pro Ser Ser Gly His Pro 
705                 710                 715                 720 


Phe Leu Ser Ala Thr Met Glu Thr Ala His Arg Tyr Thr Glu Gly Phe 
                725                 730                 735     


Tyr Lys Cys Tyr Leu Glu Lys Lys Arg Glu Trp Leu Ala Lys Ile Phe 
            740                 745                 750         


Tyr Arg Pro Glu Gln Asp Glu Asn Thr Lys Arg Arg Ile Ser Val Phe 
        755                 760                 765             


Phe Val Pro Asp Gly Glu Ala Arg Lys Leu Leu Pro Leu Leu Ile Arg 
    770                 775                 780                 


Arg Arg Met Lys Glu Gln Asn Asp Leu Gln Asp Trp Ile Arg Asn Lys 
785                 790                 795                 800 


Gln Ala His Pro Ile Asp Leu Pro Ser His Leu Phe Asp Ser Lys Val 
                805                 810                 815     


Met Glu Leu Leu Lys Val Lys Asp Gly Lys Lys Lys Trp Asn Glu Ala 
            820                 825                 830         


Phe Lys Asp Trp Trp Ser Thr Lys Tyr Pro Asp Gly Met Gln Pro Phe 
        835                 840                 845             


Tyr Gly Leu Arg Arg Glu Leu Asn Ile His Gly Lys Ser Val Ser Tyr 
    850                 855                 860                 


Ile Pro Ser Asp Gly Lys Lys Phe Ala Asp Cys Tyr Thr His Leu Met 
865                 870                 875                 880 


Glu Lys Thr Val Arg Asp Lys Lys Arg Glu Leu Arg Thr Ala Gly Lys 
                885                 890                 895     


Pro Val Pro Pro Asp Leu Ala Ala Asp Ile Lys Arg Ser Phe His Arg 
            900                 905                 910         


Ala Val Asn Glu Arg Glu Phe Met Leu Arg Leu Val Gln Glu Asp Asp 
        915                 920                 925             


Arg Leu Met Leu Met Ala Ile Asn Lys Met Met Thr Asp Arg Glu Glu 
    930                 935                 940                 


Asp Ile Leu Pro Gly Leu Lys Asn Ile Asp Ser Ile Leu Asp Glu Glu 
945                 950                 955                 960 


Asn Gln Phe Ser Leu Ala Val His Ala Lys Val Leu Glu Lys Glu Gly 
                965                 970                 975     


Glu Gly Gly Asp Asn Ser Leu Ser Leu Val Pro Ala Thr Ile Glu Ile 
            980                 985                 990         


Lys Ser Lys Arg Lys Asp Trp Ser  Lys Tyr Ile Arg Tyr  Arg Tyr Asp 
        995                 1000                 1005             


Arg Arg  Val Pro Gly Leu Met  Ser His Phe Pro Glu  His Lys Ala 
    1010                 1015                 1020             


Thr Leu  Asp Glu Val Lys Thr  Leu Leu Gly Glu Tyr  Asp Arg Cys 
    1025                 1030                 1035             


Arg Ile  Lys Ile Phe Asp Trp  Ala Phe Ala Leu Glu  Gly Ala Ile 
    1040                 1045                 1050             


Met Ser  Asp Arg Asp Leu Lys  Pro Tyr Leu His Glu  Ser Ser Ser 
    1055                 1060                 1065             


Arg Glu  Gly Lys Ser Gly Glu  His Ser Thr Leu Val  Lys Met Leu 
    1070                 1075                 1080             


Val Glu  Lys Lys Gly Cys Leu  Thr Pro Asp Glu Ser  Gln Tyr Leu 
    1085                 1090                 1095             


Ile Leu  Ile Arg Asn Lys Ala  Ala His Asn Gln Phe  Pro Cys Ala 
    1100                 1105                 1110             


Ala Glu  Met Pro Leu Ile Tyr  Arg Asp Val Ser Ala  Lys Val Gly 
    1115                 1120                 1125             


Ser Ile  Glu Gly Ser Ser Ala  Lys Asp Leu Pro Glu  Gly Ser Ser 
    1130                 1135                 1140             


Leu Val  Asp Ser Leu Trp Lys  Lys Tyr Glu Met Ile  Ile Arg Lys 
    1145                 1150                 1155             


Ile Leu  Pro Ile Leu Asp Pro  Glu Asn Arg Phe Phe  Gly Lys Leu 
    1160                 1165                 1170             


Leu Asn  Asn Met Ser Gln Pro  Ile Asn Asp Leu 
    1175                 1180                 


<210>  1591
<211>  1140
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1591

Met Glu Asn Asp Gln Gln Ile Leu Glu Asn Arg Arg Arg Thr Leu Ala 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Ser Asn His Leu Ala Ala Ser Phe Glu Gln Lys Val 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ala Ser Phe Leu Cys Asn Lys Ser 
    50                  55                  60                  


Ile Lys Lys Ile Asn Trp Asn His Val Tyr Ser Lys Ala Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ala Asp Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Arg Glu Thr Thr Asp Lys Glu Gly Lys Asp Phe Thr Ala Met Asn Glu 
            100                 105                 110         


Thr Leu Lys Leu Val Phe Asp Glu Leu Gln Ala Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Ala Asp Ser Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Val Glu Leu Ala Asp Phe Leu Thr Val Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Ala Asp Asp Asp Tyr 
                165                 170                 175     


Thr Met Val Glu Ser Lys Gln Ile Val Thr Pro Asp Asn Leu Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Val Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Leu Ala Tyr Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asp Leu Gly Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Glu 
            260                 265                 270         


Val Ile Thr Glu Glu Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Glu Glu Glu Arg 
    290                 295                 300                 


Glu Lys Ile Leu Asp Glu Ile Asp Tyr Glu Asp Tyr Ile Glu Ser Leu 
305                 310                 315                 320 


Thr Arg Arg Val Arg His Ser Asn Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Lys Tyr Asn Lys Gln Phe Asp Gly Glu 
        355                 360                 365             


Ala Thr Glu Cys Lys Val Val Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asn Gln Glu Thr Val Glu Leu Lys Ile Asp Ser Ala 
385                 390                 395                 400 


Gln Arg Thr Asn Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Glu Ala Arg Leu Leu 
            420                 425                 430         


Thr Lys Ala Lys Pro Glu Ser Lys Val Ser Tyr Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Lys Ala Glu Glu Met Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Lys Val Asn Asp Ser Gln Leu Met Ser Met Gln Phe Ile Asp Glu 
                485                 490                 495     


Ile Lys Glu Gln Leu Pro Ala Asp Trp Asn Glu Phe Gly Lys Arg Ser 
            500                 505                 510         


Asp Ser Lys Lys Lys Lys Ala Tyr Thr Asn Ala Ala Leu Gln Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Lys Val Leu Ala Asn Tyr Gln Leu 
    530                 535                 540                 


Asn Asp Lys Gln Val Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Ser Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Val Glu Lys His Lys Leu 
            580                 585                 590         


Asp Lys Ser Ala Arg Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Thr Asp Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Phe Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Tyr 
625                 630                 635                 640 


Ala Asp Thr Asp Lys Lys Ala Thr Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Lys Gly Gly His Pro Phe Leu Ala Asn Ile Asn 
            660                 665                 670         


Leu Arg Gln Ile Arg Lys Thr Ser Gln Leu Tyr Glu Leu Tyr Leu Val 
        675                 680                 685             


Glu Lys Ala Asn Lys Gln Val Lys Lys Met Asn Pro Lys Thr Gln Arg 
    690                 695                 700                 


Thr Ser Asn Val Asp Glu Ser Trp Met Met Lys Ser Phe Tyr Ala Lys 
705                 710                 715                 720 


Glu Trp Asn Glu Glu Met Gly Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Val Asn Lys Thr Asn Ile Pro Phe Thr Ile Arg Gln Trp Glu Glu Lys 
            740                 745                 750         


Glu Lys His Asn Leu Gln Ala Trp Leu His Asn Ile Thr Lys Gly Lys 
        755                 760                 765             


Thr Ser Lys Asp Gly Lys Lys Ala Ile Asp Leu Pro Thr Asn Leu Phe 
    770                 775                 780                 


Asp Asp Thr Leu Cys Glu Leu Leu Arg Glu Ala Leu Ile Asn Gln Gly 
785                 790                 795                 800 


Ile Asp Ala Thr Pro Thr Thr Lys Tyr Asn Glu Leu Leu Lys Gln Trp 
                805                 810                 815     


Trp Thr Ala Arg Glu Asp Ser Thr Gln Asp Phe Tyr Leu Ser Glu Arg 
            820                 825                 830         


Gln Tyr Asp Ile Tyr Asp Glu Lys Val Cys Phe Thr Ile Asn Ser Ser 
        835                 840                 845             


Ala His Phe Ala Asp Tyr Tyr Ala Pro Ala Leu Asn Lys Ala Tyr Ser 
    850                 855                 860                 


Arg Leu Arg Ala Glu Arg Asp Val Ala Arg Arg Thr Asp Lys Arg Leu 
865                 870                 875                 880 


Pro Pro Val Glu Arg Lys Asp Val Glu Arg Val Phe Lys Asn Thr Ile 
                885                 890                 895     


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
            900                 905                 910         


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asn Gln Gln Gln Leu Lys 
        915                 920                 925             


Leu Ser Lys Met Asp Ser Leu Leu Asn Glu Thr Lys Arg Ile Glu Gln 
    930                 935                 940                 


Thr Ile Asn Thr Gln Leu Ser Phe Asp His Lys Gly Lys Glu Ile Lys 
945                 950                 955                 960 


Asp Lys Thr Asn Ser Glu Ile Val Lys Thr Ile Val Ala Glu Arg Lys 
                965                 970                 975     


Gln Lys Asn Tyr Thr Glu Met Arg Lys Tyr Val His Asp Arg Arg Leu 
            980                 985                 990         


Pro Glu Leu Phe Glu Tyr Ile Asp  Gly Asn Glu Leu Pro  Leu Asp Val 
        995                 1000                 1005             


Leu Leu  Asn Glu Leu Arg Ala  Tyr Asn Thr Ala Lys  Gln Met Val 
    1010                 1015                 1020             


Phe Asp  Thr Val Phe Ala Leu  Glu Lys Lys Ile Ile  Glu Thr Asp 
    1025                 1030                 1035             


Pro Glu  Gly Leu Lys Gln Leu  Asn Val Gly Lys Asn  Gly Gln Ile 
    1040                 1045                 1050             


Gln Thr  Gly Asn Ile Gln His  Lys Pro Tyr Val Gln  Trp Leu Glu 
    1055                 1060                 1065             


Asn Lys  Gly Leu Ile Thr Asp  His Gln Lys Gln Phe  Ile Asn Met 
    1070                 1075                 1080             


Val Arg  Asn Ser Phe Ser His  Asn Gln Phe Pro Gln  Arg Ser Thr 
    1085                 1090                 1095             


Val Glu  Leu Leu Met Pro Glu  Trp Gln Asn Thr Asp  Ile Ala Leu 
    1100                 1105                 1110             


Gln Ile  Ala Arg Glu Tyr Gln  Gln Leu Ile Val Asp  Ile Ile Glu 
    1115                 1120                 1125             


Lys Ser  Leu His Pro His Lys  Gln His Gln Met Val  
    1130                 1135                 1140 


<210>  1592
<211>  1129
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1592

Met Glu Thr Asn Gln Gln Thr His Glu Asn Arg Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Asn Asn His Ile Ala Thr Asp Phe Lys Gln Ala Thr 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ala Ala Phe Leu Cys Asn Lys Thr 
    50                  55                  60                  


Ile Lys Asn Leu Asn Trp Asn His Val His Thr Arg Ala Val Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ser Glu Ser Leu Pro Lys Asp Glu 
                85                  90                  95      


Arg Glu Asn Ser Asp Thr Glu Gly Lys Asp Phe Ala Ser Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Ser Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gln Asp Ser Arg Lys Leu Thr Val 
    130                 135                 140                 


Ser Pro Glu Leu Ala Asn Phe Leu Thr Val Asn Phe Gln Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Ala Arg Met Lys Asp Val Leu Thr Asp Ala Asp Tyr 
                165                 170                 175     


Ala Leu Val Glu Asn Leu Gln Met Val Ala Pro Asp Asn Lys Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ala Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Thr Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asn Leu Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Ser 
            260                 265                 270         


Val Ile Thr Asp Lys Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Asp Asp Glu Arg 
    290                 295                 300                 


Glu Arg Ile Leu Asp Glu Ile Asp Tyr Gln Asp Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg Tyr Ser Asn Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Asp Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Asn Tyr Thr Lys Gln Phe Ala Gly Glu 
        355                 360                 365             


Gln Ala Glu Arg Lys Val Leu Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asp Pro Glu Leu Ile Gln Gln Arg Ile Asp Lys Gln 
385                 390                 395                 400 


Gln His Thr Ala Gly Phe Asp Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Thr Lys Glu Asn Ile Ala Thr Leu Ile 
            420                 425                 430         


Ala Lys Ser Lys Ala Ser Ser Lys Val Glu His Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Gln Ala Glu Glu Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Ile Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Ser Gln Leu Pro Ala Asp Trp Asp Glu Phe Ser Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asp Ser Thr Leu Lys Tyr Leu 
        515                 520                 525             


Arg Gln Arg Lys Thr Thr Leu Asn Thr Ile Leu Ser Lys Ser Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Lys Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Thr Arg Leu Lys Ala Val Glu Lys His Lys Leu 
            580                 585                 590         


Asn Lys Ser Val Lys Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Glu Glu Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Ala Asn Ala Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Asn Asp Gly His Pro Phe Leu Gln Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Gln Ala Tyr Leu Ile 
        675                 680                 685             


Glu Lys Gly Asn Lys Met Val Pro Arg Leu Asn Pro Lys Thr Asn Lys 
    690                 695                 700                 


Thr Ser Lys Val Asp Glu Ser Trp Met Met Lys Gln Phe Tyr Val Lys 
705                 710                 715                 720 


Glu Trp Lys Glu Glu Ile Gly Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Ser Arg Ile Pro Phe Thr Ile Cys Gln Trp Asp Lys Lys 
            740                 745                 750         


Glu Ser His Asp Leu Asn Thr Trp Leu Gln His Val Thr Val Gly Lys 
        755                 760                 765             


Asn Lys Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe Asp 
    770                 775                 780                 


Glu Ala Leu Cys Asp Leu Leu Arg Glu Gln Leu Asp Thr Lys Ile Val 
785                 790                 795                 800 


Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Ile Trp Trp 
                805                 810                 815     


Lys Thr Arg Asn Asp Asp Thr Gln Gln Phe Tyr Gln Ser Glu Arg Glu 
            820                 825                 830         


Tyr Asp Ile Tyr Asn Glu Lys Val Arg Phe Lys Ile Asp Ser Ser Ala 
        835                 840                 845             


His Phe Ala Asp Tyr Tyr Lys Asn Ala Leu Ser Arg Ala Phe Thr Arg 
    850                 855                 860                 


Leu Lys Ala Glu Arg Glu Thr Ala Arg Gln Thr Asn Lys Lys Leu Pro 
865                 870                 875                 880 


Pro Leu Glu Tyr Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile Ala 
                885                 890                 895     


Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met Ala 
            900                 905                 910         


Val Leu Met Leu Glu Arg Leu Met Asp Asn Ser Pro Asn Leu Arg Leu 
        915                 920                 925             


Ser Lys Ile Glu Thr Leu Leu Asn Asp Thr Thr His Ile Ser Glu Lys 
    930                 935                 940                 


Ile Ser Ala Thr Leu Ser Phe Asp Ala Ser Gly Glu Arg Ile Ser Gly 
945                 950                 955                 960 


Lys Leu Lys Gln Thr Val Thr Lys Thr Leu Ile Ala Glu Arg Lys Gln 
                965                 970                 975     


Lys Asn Tyr Thr Glu Leu Arg Lys Tyr Arg Tyr Asp Arg Arg Leu Pro 
            980                 985                 990         


Glu Leu Phe Glu Tyr Val Gln Ala  Asp Glu Ile Pro Leu  Glu Trp Leu 
        995                 1000                 1005             


Leu Glu  Glu Leu Ser Ala Tyr  Asn Asn Ala Lys Gln  Gln Val Phe 
    1010                 1015                 1020             


Asp Thr  Val Phe Ala Leu Glu  Lys Lys Ile Val Gly  Thr Asp Pro 
    1025                 1030                 1035             


Asp Gly  Leu Lys Ser Leu Phe  Thr Asn Pro Lys Gly  Glu Pro Leu 
    1040                 1045                 1050             


Lys Gly  Asn Ile Gln His Lys  Pro Tyr Val Gln Trp  Leu Thr Asn 
    1055                 1060                 1065             


Lys Gly  Leu Ile Asn Lys Glu  Glu Lys Gln Phe Ile  Asn Met Val 
    1070                 1075                 1080             


Arg Lys  Cys Phe Ser His Asn  Gln Phe Pro Gln Arg  Lys Thr Met 
    1085                 1090                 1095             


Glu Leu  Leu Ile Pro Ala Trp  Asn Glu Lys Lys Leu  Ala Leu Gln 
    1100                 1105                 1110             


Ile Ala  Thr Val Tyr Asn Gln  Leu Ile Ala Asp Leu  Thr Asp Lys 
    1115                 1120                 1125             


Ile 
    


<210>  1593
<211>  1047
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1593

Met Glu Thr Glu Val Thr Ala Gln Asn Asn Ser Leu Thr Leu Thr Asn 
1               5                   10                  15      


Asn Pro Tyr Tyr Phe Ala His Tyr Ala Asn Met Ala Arg His Asn Ala 
            20                  25                  30          


Tyr Ile Val Leu Asn Glu Ile Asn Glu Lys Ile Tyr Asn Asn Lys Val 
        35                  40                  45              


Lys Ile Pro Glu Asp Gly Leu Ser Glu Cys Lys Leu Val Asn Ser Phe 
    50                  55                  60                  


Ser Lys Lys Asn Lys Lys Ala Asp Glu Tyr Ala Arg Ile Ile Lys Leu 
65                  70                  75                  80  


Leu Thr Glu His Tyr Pro Phe Ile Arg Phe Tyr Ala Asp Ser Ser Lys 
                85                  90                  95      


Glu Met Gly Asn Ile Pro Leu Lys Ala Tyr Leu Asp Ile Leu Asp Lys 
            100                 105                 110         


Ile Arg Asn Glu Asn Asn His Tyr Asn His Thr Ala Glu Arg Lys Glu 
        115                 120                 125             


Ile Ser Lys Ile Gln Glu Leu Phe Leu Phe Ala Lys Glu Lys Ala Lys 
    130                 135                 140                 


Gly Arg Met Ile Glu Phe Ser Pro Glu Asp Phe Asp His Leu Asn Asn 
145                 150                 155                 160 


Ser Lys Tyr Tyr Ala Met Thr Glu Asp Gly Ser Leu Thr Asn Thr Gly 
                165                 170                 175     


Ile Tyr Phe Phe Leu Cys Leu Phe Leu Glu Lys Lys His Ala Phe Gln 
            180                 185                 190         


Phe Leu Ser Arg Ile Lys Gly Phe Lys His Arg Glu Gln Lys Ser His 
        195                 200                 205             


Arg Ala Thr Leu Glu Thr Phe Thr Gln Leu Cys Cys Arg Leu Pro Tyr 
    210                 215                 220                 


Pro Lys Leu Glu Ser Ser Asp Val Ala Leu Asp Met Leu Asn Glu Ile 
225                 230                 235                 240 


Ala Arg Cys Pro Asn Ala Leu Tyr Gly Val Leu Glu Asn Lys Asp Lys 
                245                 250                 255     


Glu Thr Phe Lys Val Glu Phe Lys Asn Gly Ala Thr Asn Asn Glu Met 
            260                 265                 270         


Glu Val Pro Glu Pro Val Met Lys Arg His Asp Asp Arg Phe Pro Tyr 
        275                 280                 285             


Phe Ala Leu Arg Tyr Phe Asp Lys Ser Gln Ala Leu Asp Gly Ile Thr 
    290                 295                 300                 


Ser His Leu Gln Leu Gly Arg Arg Ile Val Ser Asp Pro His Gln Lys 
305                 310                 315                 320 


Lys Ile Gly Ala Glu Val Arg Thr His Glu Ile Leu Lys Asp Met Arg 
                325                 330                 335     


Thr Ala His Gln Leu Ala Tyr Phe Glu Thr Asp Ala Ala Lys Glu Phe 
            340                 345                 350         


Tyr Thr Asn Ile Pro Val Val Glu His Tyr Ala Pro Gln Tyr Arg Ile 
        355                 360                 365             


Val Gly Asn Arg Ile Gly Leu Phe Phe Asp Tyr Glu Cys Trp Gly Lys 
    370                 375                 380                 


Tyr Thr Val Pro Lys Glu Asn Val Lys Pro Asp Ala Ile Ile Ser Ile 
385                 390                 395                 400 


His Asp Leu Gly Ala Leu Tyr Phe Tyr Asn Arg Leu Tyr Lys Glu Gly 
                405                 410                 415     


Ser Val Lys Gln Ser Pro Lys Glu Leu Met Lys Ser Tyr Leu Glu Asn 
            420                 425                 430         


Met Asn Arg Leu Phe Asp Asp Val Lys Lys Gly Asn Ile Lys Pro Val 
        435                 440                 445             


Asn Asp Gly Glu Lys Leu Thr Pro Leu Phe Lys Ile Lys Asp Lys Glu 
    450                 455                 460                 


Asp Glu Tyr Glu Ile Arg Leu Glu Asn Leu Lys Glu Leu Ser Ala Leu 
465                 470                 475                 480 


Leu Gln Thr Glu Leu Asp Lys Arg Gly Tyr Gly Ile Glu Val Lys Asn 
                485                 490                 495     


Leu Pro Asp Val Cys Arg Glu Tyr Leu Leu Gly Tyr Lys Glu Ser Ser 
            500                 505                 510         


Ala Lys Asp Lys Ala Lys Arg Arg Phe Lys Arg Met Leu Arg Glu Thr 
        515                 520                 525             


Gln Phe Ala Leu Lys Lys Val Glu Arg Val Leu Ile Gln Glu Thr Ser 
    530                 535                 540                 


Leu Leu Ala Ser Gly Leu Lys Val Gly Glu Met Ala Gln Glu Leu Ala 
545                 550                 555                 560 


Arg Asp Ile Val Phe Leu Ile Lys Pro Lys Ile Val Lys Lys Ile Ile 
                565                 570                 575     


Lys Ser Gly Thr Asp Ala Gly Lys Glu Val Glu Cys Lys Gln Lys Ile 
            580                 585                 590         


Asn Asn Met Glu Phe Asp Val Leu Gln Lys Met Leu Ala Phe Tyr Pro 
        595                 600                 605             


Val Tyr Lys Glu Glu Ile Glu His Phe Leu Trp Thr Met Val Asn Lys 
    610                 615                 620                 


Arg Asp Pro Asn Ala Phe Ser His Pro Phe Leu Phe Arg Ala Leu Leu 
625                 630                 635                 640 


Lys Ile Lys Thr Cys Arg Asn Leu Asn Asp Phe Tyr Lys Glu Tyr Tyr 
                645                 650                 655     


Leu His Lys Gln Arg Trp Ile Glu Gly Val Ser Lys Ser Ile Thr Pro 
            660                 665                 670         


Glu Val Leu Arg Asp Asn Glu Tyr Phe Leu Lys Leu Glu Asn Gly Asn 
        675                 680                 685             


Ala Phe Pro His Asn Tyr Asn Gly Glu Ala Ile Phe Ile Pro Ser Gly 
    690                 695                 700                 


Phe Phe Asn Lys Glu Ile Thr Arg Ala Met Val Gln Ile Gly Tyr Lys 
705                 710                 715                 720 


Ile Glu Asn Pro Glu Lys Gly Ala Asn Ala Ala Tyr Trp Ile Lys Gln 
                725                 730                 735     


Tyr Phe Glu Gly Lys Ser Gln Pro Phe Tyr Asn Leu Pro Arg Tyr Tyr 
            740                 745                 750         


Asn Glu Ser Leu Gly Gly Lys Glu Pro Val Tyr Ile Glu Arg Asp Lys 
        755                 760                 765             


Leu Lys Lys Gln Ile Leu Glu Gly Asp Phe Asn Arg Leu Thr Glu Asp 
    770                 775                 780                 


Glu Gln Lys Arg Arg Lys Val Leu Ala Lys Arg Ile Arg Glu Asn Glu 
785                 790                 795                 800 


Ser Glu Ile Leu Thr Asn Gln Thr Asn Asp Arg Val Met Tyr Leu Met 
                805                 810                 815     


Ala Met Glu Leu Ile Asp Ser Glu Asn Pro Leu Lys Lys Asn Glu Ile 
            820                 825                 830         


Val Ser Val Gly Tyr Asn Ile Lys Glu Gly Thr Asn Leu Leu Asp Asn 
        835                 840                 845             


Asn Lys Val Ser Trp Asn Ile Gln Gly Arg Arg Val Val Ala Glu Leu 
    850                 855                 860                 


Pro Ile Lys Arg Tyr Gly Glu Tyr Arg Arg Phe Leu Lys Asp Arg Arg 
865                 870                 875                 880 


Leu Glu Asn Leu Leu Lys Tyr Tyr Pro Glu Gly Lys Glu Leu Gln Leu 
                885                 890                 895     


Gly Thr Leu Lys Ser Gly Glu Val Glu Glu Lys Gly Lys Lys Tyr Thr 
            900                 905                 910         


Asn Ser Asn Leu Val Asp Glu Leu Glu Leu Phe Asp Leu Lys Arg Asn 
        915                 920                 925             


Glu Leu Met Glu Gln Val Tyr Leu Phe Glu Lys Ile Leu Cys Thr Asn 
    930                 935                 940                 


Tyr Ala Asp Lys Ile Lys Ala Val Leu Pro Asp Lys Glu Arg Asn Lys 
945                 950                 955                 960 


Pro Tyr Ile Glu His Tyr His Cys Leu Met Tyr Ala Lys Asn Glu Met 
                965                 970                 975     


Lys Leu Phe Lys Glu Val Gly Glu Leu Glu His Glu His Phe Asn Glu 
            980                 985                 990         


Leu Arg Asn Lys Ile Ser His Asn  Gln Met Pro Tyr Thr  Asp Trp Leu 
        995                 1000                 1005             


Met Glu  Arg Val Ile Ala Asn  Lys Glu Glu Pro Met  Ile Thr Asn 
    1010                 1015                 1020             


Arg Ile  Val Asp Leu Ile Leu  Ser Ile Tyr Lys Glu  Leu Asn Ser 
    1025                 1030                 1035             


Gln Leu  Val Ile Ile Thr Asn  Ser Lys 
    1040                 1045         


<210>  1594
<211>  1138
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1594

Met Glu Thr Gln Glu Asn Glu Leu Phe Glu Asn Arg Arg Arg Thr Leu 
1               5                   10                  15      


Ala Asp Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Leu Ala Arg Leu 
            20                  25                  30          


Asn Ile Phe Ser Ile Asn Asn Tyr Leu Ala Lys Glu Phe Gln Gln Thr 
        35                  40                  45              


Glu Leu Lys Asp Asp Glu Leu Ile Gln Asn Gly Phe Ile Cys Ile Pro 
    50                  55                  60                  


Ser Gln Lys Asn Arg Asn Asp Asn Lys Leu Phe Glu Arg Leu Ile Arg 
65                  70                  75                  80  


Leu Met Pro Val Ile Lys Gln Phe Asp Ala Ala Arg Leu Pro Glu Asp 
                85                  90                  95      


Glu Gln Gln Ser Gly Gln Ala Glu Gly Lys Asp Ile Lys Ala Met Ala 
            100                 105                 110         


Lys Thr Leu Lys Ala Leu Phe Lys Asp Met Gln Glu Phe Arg Asn Asp 
        115                 120                 125             


Tyr Thr His Phe Tyr Ala Thr Asp Lys Gln Glu Cys Arg Lys Leu Thr 
    130                 135                 140                 


Val Leu Pro Glu Thr Ala Thr Phe Leu Lys Ala Ser Phe Ala Arg Ala 
145                 150                 155                 160 


Ile Glu Tyr Ser Lys Ser Arg Phe Lys Asp Val Leu Ser Glu Asp Asp 
                165                 170                 175     


Tyr Ser Ile Val Ala Gly Lys Glu Leu Val Ser Asp Asp Asn Thr Ile 
            180                 185                 190         


Thr Thr Glu Gly Leu Val Phe Leu Thr Ser Leu Phe Leu Asp Arg Glu 
        195                 200                 205             


Asn Ala Phe Gln Phe Ile Gly Lys Val Gln Gly Leu Lys Gly Thr Gln 
    210                 215                 220                 


Phe Lys Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ala Tyr Cys Val 
225                 230                 235                 240 


Arg Leu Pro His Asp Lys Leu Ile Ser Asp Asn Pro Ile Gln Ala Leu 
                245                 250                 255     


Leu Phe Asp Met Leu Asn Glu Leu Asn Lys Cys Pro Lys Lys Leu Tyr 
            260                 265                 270         


Asn Val Leu Ser Glu Glu Val Lys Lys Glu Phe Arg Pro Glu Leu Ser 
        275                 280                 285             


Glu Ser Gly Ile Glu Asn Met Leu Ala Asn Ser Phe Asn Asp Glu Glu 
    290                 295                 300                 


Arg Glu Lys Leu Leu Asp Glu Ile Glu Tyr Lys Glu Tyr Ile Glu Gln 
305                 310                 315                 320 


Leu Thr Ile Arg Val Arg His Ser Asn Arg Phe His Tyr Phe Ala Met 
                325                 330                 335     


Arg Phe Ile Asp Glu Gln Glu Leu Trp Pro Gly Ile Arg Phe Gln Ile 
            340                 345                 350         


Asp Leu Gly Lys Tyr Thr Leu Thr Gln Tyr Asp Lys Gln Val Leu Gly 
        355                 360                 365             


Glu Ser Ile Pro Arg Ser Val Val Glu Asn Thr Arg Ala Phe Gly Arg 
    370                 375                 380                 


Leu Ser Asn Phe Leu Thr Ala Asp Pro Asp Ser Leu Glu Gln Arg Ile 
385                 390                 395                 400 


Asp Val Asp His Arg Ala Asn Gly Phe Glu Gln Phe Ala Pro His Tyr 
                405                 410                 415     


Asn Ala Asp Ile Asn Lys Ile Gly Ile Ala Phe Thr Glu Lys Glu Gln 
            420                 425                 430         


Leu Pro Tyr Ile Val Arg Thr Lys Asn Ala Glu Thr Asn Arg Val Lys 
        435                 440                 445             


Tyr Ser Phe Lys Gln Pro Gln Pro Asp Ala Phe Ile Ser Leu His Glu 
    450                 455                 460                 


Leu Ala Lys Ala Ile Leu Leu Glu Gln Leu Gln Pro Gly Glu Ser Glu 
465                 470                 475                 480 


Lys Leu Ile Arg Ala Phe Cys Ser Thr Ala Glu Asn Lys Leu Phe Asn 
                485                 490                 495     


Pro Glu Phe Ile Glu Ser Ile Lys Trp Lys Leu Pro Asp Trp Lys Pro 
            500                 505                 510         


Phe Gln Lys Gln Cys Asp Thr Lys Lys Ser Arg Ala Tyr Ile Thr Lys 
        515                 520                 525             


Arg Asn Met Phe Ala Tyr Ala Pro Arg Asp Arg Lys Lys Leu Leu Asp 
    530                 535                 540                 


Glu Leu Leu Ala Pro Tyr Gly Leu Asn Arg Lys Gln Val Pro Glu Arg 
545                 550                 555                 560 


Ile Leu Asn Tyr Trp Leu Asn Ile Glu Glu Val His Asp Ala Arg Ser 
                565                 570                 575     


Val Asn Glu Arg Leu Leu Leu Met Lys Arg Asp Gly Leu Gln Arg Leu 
            580                 585                 590         


Lys Gln Leu Glu Lys His Arg Lys Asp Pro Ser Ile Arg Ile Pro Lys 
        595                 600                 605             


Val Gly Glu Met Ala Thr Phe Leu Ala Arg Asp Ile Val Asp Met Met 
    610                 615                 620                 


Ile Asp Gly Thr Lys Lys Lys Lys Ile Thr Ser Ile Tyr Tyr Asp Lys 
625                 630                 635                 640 


Met Gln Glu Cys Leu Ala Phe Tyr Ala Asp Ala Glu Lys Lys Gln Gln 
                645                 650                 655     


Phe Ile Asp Leu Val Cys Glu Leu Asp Leu Asn Asp Met Gly Gly His 
            660                 665                 670         


Pro Phe Leu Lys Asn Leu Asn Leu Glu Ser Ile Gly Lys Thr Ser Glu 
        675                 680                 685             


Phe Tyr Ser Arg Tyr Leu Glu Ala Lys Val Gln Lys Asp Val Ser Glu 
    690                 695                 700                 


Tyr Asn Tyr Lys Lys Cys Arg Glu Val Thr Lys Asn Val Ser Trp Met 
705                 710                 715                 720 


Val Lys Thr Phe Glu Thr Lys Val Trp Asn Glu Glu Ile Lys Lys Asn 
                725                 730                 735     


Leu Thr Glu Tyr Arg Ile Pro Ala Asp Lys Arg Asn Ile Pro Tyr Ser 
            740                 745                 750         


Ile Leu Gln Trp Glu Lys Glu Ala Ser Thr Leu Glu Glu Trp Leu His 
        755                 760                 765             


Ala Ile Asn His Gly Lys Gln Glu Gly Asp Arg Lys Arg Pro Ile Asp 
    770                 775                 780                 


Leu Pro Thr Asp Leu Phe Asp Ala Arg Leu Cys Glu Leu Met Lys Ala 
785                 790                 795                 800 


Gln Leu Gln Glu Lys Gly Gln Ser Pro Thr Glu Thr Ala Lys Tyr Asn 
                805                 810                 815     


Glu Leu Leu Lys Gln Trp Trp Ser Leu Arg Glu Asp Glu Thr Gln Pro 
            820                 825                 830         


Phe Tyr Asn Gly Ala Arg His Tyr Val Ile Lys Glu Glu Ala Val Cys 
        835                 840                 845             


Phe Thr Pro Gly Ala Gln Pro Arg Leu Thr Ser Cys Tyr Ala Asp Ala 
    850                 855                 860                 


Val Glu Glu Ala Tyr Asn Arg Leu Ser Ala Glu Arg Asn Ile Ala Arg 
865                 870                 875                 880 


Arg Asn Asp Lys Arg Leu Pro Pro Ile Gln Lys Gln Glu Met Glu Lys 
                885                 890                 895     


Thr Phe Lys Arg Ala Leu Tyr Asp Thr Glu Lys Glu Ile Arg Leu Leu 
            900                 905                 910         


Gly Glu Gln Asp Arg Ile Leu Leu Leu Met Ala Glu Gln Leu Ser Pro 
        915                 920                 925             


Gly Lys Glu Thr Leu Lys Leu Lys Thr Val Ala Gln Glu Leu Thr Arg 
    930                 935                 940                 


Ser Arg Glu Ile Lys Lys Glu Phe Ser Tyr Ile Ser Asn Tyr Asn Thr 
945                 950                 955                 960 


Gln Gly Glu Arg Leu Lys Lys Glu Glu Val Pro Pro Gln Leu Thr Leu 
                965                 970                 975     


Thr Val Thr Gly Ile Met Gln Leu Lys Asn Ser Asn Asp Leu Asn Arg 
            980                 985                 990         


Phe Ala His Asp Arg Arg Met Pro  Glu Leu Val Ala Tyr  Leu Pro Asn 
        995                 1000                 1005             


Ala Thr  Val Asp Ala Asp Lys  Leu Arg Tyr Glu Leu  Met Asp Tyr 
    1010                 1015                 1020             


Asn Lys  Ala Arg Leu Thr Val  Phe Asp Ala Val Phe  Lys Leu Glu 
    1025                 1030                 1035             


Lys Ala  Leu Ile Asp Gln Asp  Arg Glu Gly Val Ile  Thr Leu Phe 
    1040                 1045                 1050             


Thr Asp  Glu Gln Gly Glu Ala  Lys Gln Ser Arg Met  Gln His Lys 
    1055                 1060                 1065             


Pro Tyr  Leu Gln Trp Leu Leu  Asn Lys Gly Val Ile  Thr Gln Pro 
    1070                 1075                 1080             


Glu Ser  Cys Tyr Leu Asn Met  Leu Arg Asn Ser Phe  Ser His Asn 
    1085                 1090                 1095             


Gln Phe  Pro His Ile Ala Val  Ala Leu Asn Gly Thr  Glu Val Val 
    1100                 1105                 1110             


Pro Val  Lys Asn Ile Ala Ser  Thr Ile Ala Gly Ala  Tyr Lys Gln 
    1115                 1120                 1125             


Lys Ile  Glu Thr Ile Ile Gly  Lys Ile Gly 
    1130                 1135             


<210>  1595
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1595

Met Lys Ala Asn Asn Gln Ile Val Lys Gly Ile Ser Tyr Asp His Leu 
1               5                   10                  15      


Lys Pro Asp Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asp Gly Val Ile Gln Glu Phe Thr Met Arg Leu Asn Leu 
        35                  40                  45              


Lys Tyr Asp Pro Glu Asn Lys Asn Gln Ser Leu Phe Ser Tyr Phe Asp 
    50                  55                  60                  


Ile Asn Ala Ser Phe Thr Asp Trp Glu Arg Gly Val Asn Ile Leu Lys 
65                  70                  75                  80  


Glu Tyr Trp Pro Val Met Glu Phe Ile Asp Arg Pro Ala Thr Asp Lys 
                85                  90                  95      


Gln Phe Glu Ser Glu Lys Pro Glu Asn Arg Glu Ala Ala Lys Arg Lys 
            100                 105                 110         


Tyr Phe Ile Ala Thr Leu Arg Ile Leu Leu Lys Ser Ile Lys Glu Leu 
        115                 120                 125             


Arg His Tyr Tyr Thr His Tyr Tyr His Pro Pro Val Gln Leu Ser Glu 
    130                 135                 140                 


Asp Leu Phe Arg Phe Leu Asp His Thr Leu Leu Tyr Thr Ala Phe Asp 
145                 150                 155                 160 


Val Lys Lys Thr Lys Met Lys Asp Asp Lys Thr Arg Gln Leu Leu Asn 
                165                 170                 175     


Gln Asn Leu Ser Leu Glu Leu Glu Lys Leu Lys Lys Leu Lys Val Glu 
            180                 185                 190         


Glu Leu Lys Lys Lys Lys Glu Lys Gly Ile Lys Val Asn Leu Gln Asp 
        195                 200                 205             


Glu Lys Gly Ile Leu Asn Ala Ile Tyr Asn Asp Ala Phe Ala His Ile 
    210                 215                 220                 


Ile Thr Lys Glu Lys Asp Ser Asp Lys Asp Glu Leu Glu Thr Arg Tyr 
225                 230                 235                 240 


Lys Ser Thr Leu Pro Gln Asp Glu Thr Ala Glu Ala Gly Ile Asn Ile 
                245                 250                 255     


Ser Ile Ser Gly Leu Ile Phe Leu Leu Ser Leu Phe Leu Ser Arg Lys 
            260                 265                 270         


Glu Ile Glu Gln Leu Lys Ser Asn Ile Glu Gly Tyr Lys Gly Lys Val 
        275                 280                 285             


Leu Asn Ile Glu Thr Glu Val Asp Arg Lys His Asn Ser Leu Lys Tyr 
    290                 295                 300                 


Met Ala Thr His Trp Val Phe Ser Ile Leu Ala Phe Lys Gly Leu Lys 
305                 310                 315                 320 


Gln Arg Leu Thr Asn Ser Phe Glu Lys Glu Ser Leu Leu Ile Gln Met 
                325                 330                 335     


Met Asp Glu Leu Asn Lys Val Pro Asp Glu Leu Tyr Gln Thr Leu Ser 
            340                 345                 350         


Glu Thr Ala Lys Lys Glu Phe Leu Glu Asp Ile Asn Glu Tyr Val Ser 
        355                 360                 365             


Glu Gly Asp Asp Asn Glu Lys Ala Thr Tyr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Ser Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gln Phe Pro Thr Leu Lys Phe Gln Ile Phe Val Gly 
                405                 410                 415     


Gln Tyr Leu His Asp Asn Arg Pro Lys Thr Leu Ala Ser Asn Gly Met 
            420                 425                 430         


Thr Ala Gln Arg Met Ile Lys Glu Lys Ile Asn Leu Phe Gly Asn Leu 
        435                 440                 445             


Ser Glu Val Thr Lys His Lys Ser Asp Phe Phe Glu Lys Glu Ser Ala 
    450                 455                 460                 


Ala Gln Gly Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Trp Ala Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Val Tyr Ile Asp Met Ile Gly Lys Glu Gly Lys Ala 
                485                 490                 495     


Lys Glu Ile Gln Val Gln Ile Asn Lys Tyr Arg Lys Gln Leu Asn Pro 
            500                 505                 510         


Ala Pro Gln Arg Asp Lys Arg Ile Ser Lys Lys Glu Ile Ile Glu Gln 
        515                 520                 525             


Leu Tyr Lys Glu Lys Val Val Tyr Gly Asp Pro Thr Leu Met Leu Ser 
    530                 535                 540                 


Ala Asn Glu Leu Met Ala Leu Leu Tyr Glu Leu Ile Val Asn Gly Lys 
545                 550                 555                 560 


Ser Gly Ala Glu Leu Glu Asn Lys Ile Val Glu Gln Ile Ile Ala Arg 
                565                 570                 575     


Tyr Glu Gln Ile Glu Ala Tyr Asp Pro Thr Thr Gln Gln Leu Pro Thr 
            580                 585                 590         


Asn Gln Met Pro His Lys Leu Gln Lys Ser Arg Lys Asp Ser Lys Val 
        595                 600                 605             


Thr Asp Thr Asp Lys Leu Leu Lys Thr Ile Asp Lys Glu Ile Asp Glu 
    610                 615                 620                 


Gly Asn Lys Lys Leu Glu Leu Ile Ala Cys His Arg Lys Glu Trp Glu 
625                 630                 635                 640 


Glu Ala Glu Gln Arg Lys Lys Ser Gly Lys Arg Asn Asn Pro Gly Thr 
                645                 650                 655     


Lys Ser Arg Lys His Leu Phe Tyr Ala Ser Glu Met Gly Glu Glu Ala 
            660                 665                 670         


Thr Trp Ile Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Pro Ala Arg 
        675                 680                 685             


Ala Glu Trp Lys Gly Thr His His Ser Glu Leu Gln Arg Leu Leu Ala 
    690                 695                 700                 


Phe Tyr Ser Thr Gln Arg Leu Glu Ala Trp Gln Leu Val Glu Ser Val 
705                 710                 715                 720 


Trp Thr Ala Asn Thr His Ser Phe Trp Glu Glu Asn Phe Lys Glu Ala 
                725                 730                 735     


Phe Tyr Lys Pro Glu Phe Glu Asn Phe Tyr Gly Ala Tyr Ile Glu Ile 
            740                 745                 750         


Arg Thr Lys Ile Leu Thr Thr Cys Arg Ser Ile Leu Glu Asn Asn Pro 
        755                 760                 765             


Glu Ala Thr Met Asn Asn Asp Thr Glu Lys Glu Trp Asp Lys Val Phe 
    770                 775                 780                 


Thr Leu Phe Asp Lys Arg Leu Tyr Arg Thr Ser Thr Thr Asp Glu Gln 
785                 790                 795                 800 


Lys Lys Gln Leu Leu Thr Lys Pro Phe Ala Phe Pro Arg Gly Leu Phe 
                805                 810                 815     


Asp Asp Lys Pro Thr Phe Leu Pro Gly Ser Lys Pro Asn Glu Asn Pro 
            820                 825                 830         


Glu Arg Phe Ala Ala Trp Tyr Ser Tyr Gly Tyr Thr Tyr Ser Gly Lys 
        835                 840                 845             


Phe Gln Ser Phe Tyr Asp Met Pro Arg Asn Tyr Ser Asp Trp Tyr Lys 
    850                 855                 860                 


Lys Leu Lys Glu Asp Gly Lys Leu Pro Pro Leu Asp Lys Lys Thr Glu 
865                 870                 875                 880 


Gln Glu Lys Ile Leu Arg Phe Arg Met Asp Cys Asp Leu Asn Ile Lys 
                885                 890                 895     


Tyr Ile Arg Phe Gln Asp Ile Tyr Val Lys Leu Met Val Asp Ser Leu 
            900                 905                 910         


Tyr Lys Ala Val Phe Gly Gln Gln Pro Glu Phe Asp Leu Ser His Leu 
        915                 920                 925             


Tyr Asp Thr Arg Tyr Glu Arg Tyr Glu Asn Asn Thr Ile Ala Gln Arg 
    930                 935                 940                 


Gln Lys Asn Arg Gln Glu Gly Asp Asn Ser Asp Asn Ala Ile Asn Glu 
945                 950                 955                 960 


Asn Tyr Val Trp Asn Lys Thr Phe Ala Ile Ser Leu Tyr Asn Gly Arg 
                965                 970                 975     


Ile Thr Glu Pro Gln Val Lys Leu Lys Asp Val Gly Lys Phe Arg Arg 
            980                 985                 990         


Phe Ala Ala Asp Pro Arg Val Gln  Thr Leu Ile Ser Tyr  Asp Asp Thr 
        995                 1000                 1005             


Arg Thr  Trp Thr Lys Leu Glu  Ile Glu Asn Glu Leu  Asp Asn Lys 
    1010                 1015                 1020             


Ala Asp  Ala Tyr Glu Pro Ile  Arg Arg Thr Gln Ser  Leu Lys Ala 
    1025                 1030                 1035             


Ile Gln  Gln Leu Glu Lys Asp  Ile Leu Lys Lys Asn  Gly Phe Asp 
    1040                 1045                 1050             


Gly Lys  Gln His Pro Glu Glu  Leu Lys His Asn Gly  Asn Pro Asn 
    1055                 1060                 1065             


Phe Arg  Lys Tyr Ile Ala Asn  Gly Leu Leu Lys His  Arg Thr Asp 
    1070                 1075                 1080             


Ile Arg  Gln Glu Glu Leu Ala  Leu Ile Ser Asp Thr  Glu Phe Gln 
    1085                 1090                 1095             


Glu Ile  Gly Leu Glu Arg Ile  Arg Gln Thr Asn Pro  Leu Ile Gln 
    1100                 1105                 1110             


Lys Ala  Tyr Leu Leu Ile Leu  Leu Arg Asn Lys Phe  Gly His Asn 
    1115                 1120                 1125             


Gln Leu  Pro Asp Gln Glu His  Phe Arg Leu Met Arg  Ser Ile Tyr 
    1130                 1135                 1140             


Pro Tyr  Asn Gln Gln Glu Ser  Tyr Ser Ala Tyr Phe  Asn Gln Val 
    1145                 1150                 1155             


Ile Thr  Gln Ile Ile Glu Glu  Leu Asn Thr 
    1160                 1165             


<210>  1596
<211>  1129
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1596

Met Glu Thr Asn Gln Gln Thr His Glu Asn Arg Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Asn Asn His Val Ala Thr Asp Phe Lys Arg Lys Pro 
        35                  40                  45              


Leu Pro Glu Glu Gly His Ile Pro Asp Ala Leu Leu Cys Asn Lys Thr 
    50                  55                  60                  


Ile Lys Asn Leu Asn Trp Asn His Val His Thr Arg Ala Leu Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ser Glu Ser Leu Pro Lys Asp Glu 
                85                  90                  95      


Arg Glu Asn Ser Asp Thr Glu Gly Lys Asp Phe Thr Ser Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Ser Glu Leu Gln Asp Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Asp Ser Arg Lys Leu Ile Val 
    130                 135                 140                 


Ser Pro Glu Leu Ala Asn Phe Leu Thr Val Asn Phe Gln Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Ala Arg Met Lys Asp Val Leu Thr Asp Thr Asp Tyr 
                165                 170                 175     


Ala Leu Val Glu Asn Leu Gln Met Val Ala Pro Asp Asn Lys Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ala Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Thr Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asn Leu Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Ser 
            260                 265                 270         


Val Ile Thr Asp Lys Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Asp Asp Glu Arg 
    290                 295                 300                 


Glu Thr Ile Leu Asp Glu Ile Asp Tyr Gln Asp Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg Tyr Ser Asp Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Asp Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Asn Tyr Thr Lys Gln Phe Ala Gly Glu 
        355                 360                 365             


Gln Ala Glu Arg Lys Val Leu Glu Asn Ala Asn Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asp Pro Glu Leu Ile Gln Gln Arg Ile Asp Lys Gln 
385                 390                 395                 400 


Gln His Thr Ala Gly Phe Asp Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Thr Lys Glu Asn Ile Ala Thr Leu Ile 
            420                 425                 430         


Ala Lys Ser Lys Ala Ser Ser Lys Val Glu His Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Gln Ala Glu Glu Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Ile Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Ser Gln Leu Pro Ala Asn Trp Asp Glu Phe Ser Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asp Ser Thr Leu Lys Tyr Leu 
        515                 520                 525             


Arg Gln Arg Lys Thr Thr Leu Asn Thr Ile Leu Ser Lys Ser Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Lys Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Thr Arg Leu Lys Ala Val Glu Lys His Lys Leu 
            580                 585                 590         


Asn Lys Ser Val Lys Ile Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Glu Glu Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Ala Asn Ala Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Phe Glu Asn Gly Gly His Pro Phe Leu Gln Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Gln Ala Tyr Leu Val 
        675                 680                 685             


Glu Lys Gly Asn Lys Met Val Pro Arg Leu Asn Pro Lys Thr Asn Lys 
    690                 695                 700                 


Thr Ser Lys Val Asp Glu Ser Trp Met Met Lys Gln Phe Tyr Val Lys 
705                 710                 715                 720 


Glu Trp Lys Glu Glu Ile Ala Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Ser Arg Ile Pro Phe Thr Ile Arg Gln Trp Asp Glu Lys 
            740                 745                 750         


Glu Lys Tyr Asp Leu Asn Val Trp Leu Gln His Val Thr Val Gly Lys 
        755                 760                 765             


Asn Lys Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe Asp 
    770                 775                 780                 


Glu Ala Leu Cys Asn Leu Leu Arg Glu Gln Leu Asp Thr Lys Ile Val 
785                 790                 795                 800 


Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Ile Trp Trp 
                805                 810                 815     


Lys Thr Arg Asn Asp Asp Thr Gln Gln Phe Tyr Gln Ser Glu Arg Glu 
            820                 825                 830         


Tyr Asp Ile Tyr Asn Glu Lys Val Arg Phe Lys Ile Asp Ser Ser Thr 
        835                 840                 845             


His Phe Ala Asp Tyr Tyr Lys Asn Ala Leu Ser Arg Ala Tyr Thr Arg 
    850                 855                 860                 


Leu Lys Ala Glu Arg Glu Thr Ala Arg Gln Thr Asn Lys Arg Leu Pro 
865                 870                 875                 880 


Pro Leu Glu Tyr Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile Ala 
                885                 890                 895     


Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met Ala 
            900                 905                 910         


Val Leu Met Leu Glu Gln Leu Met Asp Asn Ser Pro Asn Leu Arg Leu 
        915                 920                 925             


Ser Lys Ile Glu Thr Leu Leu Asn Asp Thr Thr Pro Ile Ser Glu Lys 
    930                 935                 940                 


Ile Ser Ala Lys Leu Ser Phe Asp Ala Ser Gly Glu Arg Ile Thr Asp 
945                 950                 955                 960 


Lys Ser Asn Pro Thr Ala Thr Lys Thr Leu Val Ala Glu Arg Lys Gln 
                965                 970                 975     


Lys Asn Tyr Thr Glu Leu Gln Lys Tyr Arg Tyr Asp Arg Arg Leu Pro 
            980                 985                 990         


Glu Leu Phe Glu Tyr Val Gln Ala  Asp Glu Ile Pro Leu  Glu Trp Leu 
        995                 1000                 1005             


Leu Asp  Glu Leu Ser Ala Tyr  Asn Ser Ala Lys Gln  Gln Val Phe 
    1010                 1015                 1020             


Asp Thr  Val Phe Ala Leu Glu  Lys Lys Ile Ile Gln  Thr Glu Pro 
    1025                 1030                 1035             


Asp Glu  Leu Lys Ser Leu Phe  Thr Gly Ala Asn Gly  Glu Leu Gln 
    1040                 1045                 1050             


Thr Gly  Asn Ile Gln His Lys  Pro Tyr Val Gln Trp  Leu Thr Asn 
    1055                 1060                 1065             


Lys Gly  Leu Ile Asn Lys Glu  Glu Lys Gln Phe Ile  Asn Met Val 
    1070                 1075                 1080             


Arg Lys  Cys Phe Ser His Asn  Gln Phe Pro Gln Arg  Thr Thr Met 
    1085                 1090                 1095             


Glu Leu  Leu Ile Pro Ala Trp  Asn Glu Lys Lys Leu  Ala Leu Gln 
    1100                 1105                 1110             


Ile Ala  Thr Val Tyr Asn Gln  Leu Ile Ala Asp Leu  Thr Asp Lys 
    1115                 1120                 1125             


Ile 
    


<210>  1597
<211>  1126
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1597

Met Glu Asp Asp Lys Lys Thr Lys Glu Ser Ile Ser Tyr Glu Leu Glu 
1               5                   10                  15      


Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val 
            20                  25                  30          


Tyr Ile Thr Val Asn His Ile Asn Lys Val Leu Glu Leu Lys Asn Lys 
        35                  40                  45              


Lys Asp Gln Asp Ile Ile Ile Asp Asn Asp Gln Asp Ile Leu Ala Ile 
    50                  55                  60                  


Lys Thr His Trp Glu Lys Val Asp Gly Asp Leu Asn Lys Thr Glu Arg 
65                  70                  75                  80  


Leu Arg Glu Leu Met Thr Lys His Phe Pro Phe Leu Glu Thr Ala Ile 
                85                  90                  95      


Tyr Ser Lys Asn Lys Glu Asp Lys Glu Glu Val Lys Gln Glu Lys Gln 
            100                 105                 110         


Ala Lys Ala Gln Ser Phe Asp Ser Leu Lys His Cys Leu Phe Leu Phe 
        115                 120                 125             


Leu Glu Lys Leu Gln Glu Ala Arg Asn Tyr Tyr Ser His Tyr Lys Tyr 
    130                 135                 140                 


Ser Glu Ser Thr Lys Glu Pro Met Leu Glu Lys Glu Leu Leu Lys Lys 
145                 150                 155                 160 


Met Tyr Asn Ile Phe Asp Asp Asn Ile Gln Leu Val Ile Lys Asp Tyr 
                165                 170                 175     


Gln His Asn Lys Asp Ile Asn Pro Asp Glu Asp Phe Lys His Leu Asp 
            180                 185                 190         


Arg Thr Glu Glu Asp Phe Asn Tyr Tyr Phe Thr Arg Asn Lys Lys Gly 
        195                 200                 205             


Asn Ile Thr Glu Ser Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Glu 
    210                 215                 220                 


Lys Lys Asp Ala Ile Trp Met Gln Gln Lys Leu Thr Gly Phe Lys Asp 
225                 230                 235                 240 


Asn Arg Glu Ser Lys Lys Lys Met Thr His Glu Val Phe Cys Arg Arg 
                245                 250                 255     


Arg Met Leu Leu Pro Lys Leu Arg Leu Glu Ser Thr Gln Thr Gln Asp 
            260                 265                 270         


Trp Ile Leu Leu Asp Met Leu Asn Glu Leu Ile Arg Cys Pro Lys Ser 
        275                 280                 285             


Leu Tyr Glu Arg Leu Gln Gly Val Asp Arg Glu Lys Phe Lys Val Pro 
    290                 295                 300                 


Phe Asp Pro Ala Asp Glu Asp Tyr Asp Ala Glu Gln Glu Pro Phe Lys 
305                 310                 315                 320 


Asn Thr Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Ala Leu Arg 
                325                 330                 335     


Tyr Phe Asp Tyr Asn Glu Val Phe Thr Asn Leu Arg Phe Gln Ile Asp 
            340                 345                 350         


Leu Gly Thr Tyr His Phe Ser Ile Tyr Lys Lys Leu Ile Gly Gly Gln 
        355                 360                 365             


Lys Glu Asp Arg His Leu Thr His Lys Leu Tyr Gly Phe Glu Arg Ile 
    370                 375                 380                 


Gln Glu Phe Ala Lys Gln Asn Arg Pro Asp Glu Trp Lys Ala Ile Val 
385                 390                 395                 400 


Lys Asp Leu Asp Thr Tyr Glu Thr Ser Asn Glu Arg Tyr Ile Ser Glu 
                405                 410                 415     


Thr Thr Pro His Tyr His Leu Glu Asn Gln Lys Ile Gly Ile Arg Phe 
            420                 425                 430         


Lys Asn Gly Asn Asn Asp Ile Trp Pro Ser Leu Glu Thr Asn Gly Glu 
        435                 440                 445             


Asn Asn Glu Lys Arg Lys Tyr Lys Leu Asp Lys Gln Tyr Gln Ala Glu 
    450                 455                 460                 


Ala Phe Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu 
465                 470                 475                 480 


Leu Leu Lys Lys Glu Lys Pro Asn Asn Asp Glu Ile Asn Ala Ser Ile 
                485                 490                 495     


Val Glu Gly Phe Ile Lys Arg Glu Ile Arg Asp Ile Tyr Lys Leu Tyr 
            500                 505                 510         


Asp Ala Phe Ala Asn Gly Glu Ile Asn Asn Ile Asp Asp Leu Glu Lys 
        515                 520                 525             


Tyr Cys Glu Asp Lys Gly Ile Pro Lys Arg His Leu Pro Lys Gln Met 
    530                 535                 540                 


Val Ala Ile Leu Tyr Asp Glu His Lys Asp Met Val Lys Glu Ala Lys 
545                 550                 555                 560 


Arg Lys Gln Lys Glu Met Val Lys Asp Thr Lys Lys Leu Leu Ala Ala 
                565                 570                 575     


Leu Glu Lys Gln Thr Gln Glu Lys Thr Glu Asp Gly Gly Arg Asn Ile 
            580                 585                 590         


Arg Leu Leu Lys Ser Gly Glu Ile Ala Arg Trp Leu Val Asn Asp Met 
        595                 600                 605             


Met Arg Phe Gln Pro Val Gln Lys Asp Asn Glu Gly Asn Pro Leu Asn 
    610                 615                 620                 


Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln Met Leu Gln Arg Ser Leu 
625                 630                 635                 640 


Ala Leu Tyr Asn Lys Glu Glu Lys Pro Thr Arg Tyr Phe Arg Gln Val 
                645                 650                 655     


Asn Leu Ile Asn Ser Ser Asn Pro His Pro Phe Leu Lys Trp Thr Lys 
            660                 665                 670         


Trp Glu Glu Cys Asn Asn Ile Leu Ser Phe Tyr Arg Ser Tyr Leu Thr 
        675                 680                 685             


Lys Lys Ile Glu Phe Leu Asn Lys Leu Lys Pro Glu Asp Trp Glu Lys 
    690                 695                 700                 


Asn Gln Tyr Phe Leu Lys Leu Lys Glu Pro Lys Thr Asn Arg Glu Thr 
705                 710                 715                 720 


Leu Val Gln Gly Trp Lys Asn Gly Phe Asn Leu Pro Arg Gly Ile Phe 
                725                 730                 735     


Thr Glu Pro Ile Arg Glu Trp Phe Lys Arg His Gln Asn Asp Ser Glu 
            740                 745                 750         


Glu Tyr Glu Lys Val Glu Ala Leu Lys Arg Val Gly Leu Val Thr Lys 
        755                 760                 765             


Val Ile Pro Leu Phe Phe Lys Glu Glu Tyr Phe Lys Glu Asp Ala Gln 
    770                 775                 780                 


Lys Glu Ile Asn Asn Cys Val Gln Pro Phe Tyr Gly Phe Pro Tyr Asn 
785                 790                 795                 800 


Val Gly Asn Ile His Lys Pro Lys Glu Glu Asp Phe Leu His Arg Glu 
                805                 810                 815     


Glu Arg Ile Glu Leu Trp Asp Lys Lys Lys Asp Lys Phe Lys Gly Tyr 
            820                 825                 830         


Lys Ala Lys Lys Lys Phe Lys Glu Met Thr Asp Lys Glu Lys Glu Glu 
        835                 840                 845             


His Arg Ser Tyr Leu Glu Phe Lys Ser Trp Asn Gln Phe Glu Arg Glu 
    850                 855                 860                 


Leu Arg Leu Val Arg Asn Gln Asp Ile Val Thr Trp Leu Leu Cys Met 
865                 870                 875                 880 


Glu Leu Ile Asp Lys Leu Lys Val Glu Gly Leu Asn Val Glu Glu Leu 
                885                 890                 895     


Gln Lys Leu Arg Leu Lys Asp Ile Asp Thr Asp Thr Ala Lys Gln Glu 
            900                 905                 910         


Lys Asn Asn Ile Leu Asn Arg Val Met Pro Met Gln Leu Pro Val Thr 
        915                 920                 925             


Val Tyr Glu Ile Asp Asp Ser His Asn Ile Val Lys Asp Arg Pro Leu 
    930                 935                 940                 


His Thr Val Tyr Ile Glu Glu Thr Lys Thr Lys Leu Leu Lys Gln Gly 
945                 950                 955                 960 


Asn Phe Lys Ala Leu Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser 
                965                 970                 975     


Phe Val Asp Thr Ser Ser Glu Ala Glu Leu Lys Ser Asn Pro Ile Ser 
            980                 985                 990         


Lys Ser Val Val Glu Tyr Glu Leu  Gly Glu Tyr Gln Asn  Ala Arg Ile 
        995                 1000                 1005             


Glu Thr  Ile Lys Asp Met Leu  Leu Leu Glu Glu Thr  Leu Ile Lys 
    1010                 1015                 1020             


Lys Asp  Lys Asn Leu Pro Thr  Asn Asn Phe Ser Asp  Met Leu Asn 
    1025                 1030                 1035             


Gly Trp  Leu Glu Gly Lys Asp  Glu Ala Asp Lys Val  Arg Phe Gln 
    1040                 1045                 1050             


Asn Asp  Val Lys Leu Leu Val  Ala Val Arg Asn Ala  Phe Ser His 
    1055                 1060                 1065             


Asn Gln  Tyr Pro Met Arg Asn  Arg Ile Ala Phe Ala  Asn Ile Asn 
    1070                 1075                 1080             


Pro Phe  Ser Leu Ser Ser Ala  Asn Thr Ser Glu Glu  Lys Gly Leu 
    1085                 1090                 1095             


Gly Ile  Ala Asn Gln Leu Lys  Asp Lys Thr Lys Glu  Thr Ile Glu 
    1100                 1105                 1110             


Lys Ile  Ile Lys Ile Glu Lys  Pro Ile Glu Thr Lys  Glu 
    1115                 1120                 1125     


<210>  1598
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1598

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Ala Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Asn Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1599
<211>  1184
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1599

Met Glu Arg Ile Phe Gly His Cys Cys Pro His His Asp Ser Val Cys 
1               5                   10                  15      


Phe Val Arg Phe Leu Gly Thr Met Val Ser Asn Gln Asp Gly Arg Glu 
            20                  25                  30          


Asn Val Leu Asp Ile Leu Tyr Ile Ala Asp Arg Thr Arg Lys Leu Lys 
        35                  40                  45              


Pro Met Asn Thr Val Pro Ala Ser Glu Asn Lys Gly Gln Ser Arg Thr 
    50                  55                  60                  


Val Glu Asp Asp Pro Gln Tyr Phe Gly Leu Tyr Leu Asn Leu Ala Arg 
65                  70                  75                  80  


Glu Asn Leu Ile Glu Val Glu Ser His Val Arg Ile Lys Phe Gly Lys 
                85                  90                  95      


Lys Lys Leu Asn Glu Glu Ser Leu Lys Gln Ser Leu Leu Cys Asp His 
            100                 105                 110         


Leu Leu Ser Val Asp Arg Trp Thr Lys Val Tyr Gly His Ser Arg Arg 
        115                 120                 125             


Tyr Leu Pro Phe Leu His Tyr Phe Asp Pro Asp Ser Gln Ile Glu Lys 
    130                 135                 140                 


Asp His Asp Ser Lys Thr Gly Val Asp Pro Asp Ser Ala Gln Arg Leu 
145                 150                 155                 160 


Ile Arg Glu Leu Tyr Ser Leu Leu Asp Phe Leu Arg Asn Asp Phe Ser 
                165                 170                 175     


His Asn Arg Leu Asp Gly Thr Thr Phe Glu His Leu Glu Val Ser Pro 
            180                 185                 190         


Asp Ile Ser Ser Phe Ile Thr Gly Thr Tyr Ser Leu Ala Cys Gly Arg 
        195                 200                 205             


Ala Gln Ser Arg Phe Ala Asp Phe Phe Lys Pro Asp Asp Phe Val Leu 
    210                 215                 220                 


Ala Lys Asn Arg Lys Glu Gln Leu Ile Ser Val Ala Asp Gly Lys Glu 
225                 230                 235                 240 


Cys Leu Thr Val Ser Gly Leu Ala Phe Phe Ile Cys Leu Phe Leu Asp 
                245                 250                 255     


Arg Glu Gln Ala Ser Gly Met Leu Ser Arg Ile Arg Gly Phe Lys Arg 
            260                 265                 270         


Thr Asp Glu Asn Trp Ala Arg Ala Val His Glu Thr Phe Cys Asp Leu 
        275                 280                 285             


Cys Ile Arg His Pro His Asp Arg Leu Glu Ser Ser Asn Thr Lys Glu 
    290                 295                 300                 


Ala Leu Leu Leu Asp Met Leu Asn Glu Leu Asn Arg Cys Pro Arg Ile 
305                 310                 315                 320 


Leu Tyr Asp Met Leu Pro Glu Glu Glu Arg Ala Gln Phe Leu Pro Ala 
                325                 330                 335     


Leu Asp Glu Asn Ser Met Asn Asn Leu Ser Glu Asn Ser Leu Asn Glu 
            340                 345                 350         


Glu Ser Arg Leu Leu Trp Asp Gly Ser Ser Asp Trp Ala Glu Ala Leu 
        355                 360                 365             


Thr Lys Arg Ile Arg His Gln Asp Arg Phe Pro Tyr Leu Met Leu Arg 
    370                 375                 380                 


Phe Ile Glu Glu Met Asp Leu Leu Lys Gly Ile Arg Phe Arg Val Asp 
385                 390                 395                 400 


Leu Gly Glu Ile Glu Leu Asp Ser Tyr Ser Lys Lys Val Gly Arg Asn 
                405                 410                 415     


Gly Glu Tyr Asp Arg Thr Ile Thr Asp His Ala Leu Ala Phe Gly Lys 
            420                 425                 430         


Leu Ser Asp Phe Gln Asn Glu Glu Glu Val Ser Arg Met Ile Ser Gly 
        435                 440                 445             


Glu Ala Ser Tyr Pro Val Arg Phe Ser Leu Phe Ala Pro Arg Tyr Ala 
    450                 455                 460                 


Ile Tyr Asp Asn Lys Ile Gly Tyr Cys His Thr Ser Asp Pro Val Tyr 
465                 470                 475                 480 


Pro Lys Ser Lys Thr Gly Glu Lys Arg Ala Leu Ser Asn Pro Arg Ser 
                485                 490                 495     


Met Gly Phe Ile Ser Val His Asp Leu Arg Lys Leu Leu Leu Met Glu 
            500                 505                 510         


Leu Leu Cys Glu Gly Ser Phe Ser Arg Met Gln Ser Asp Phe Leu Arg 
        515                 520                 525             


Lys Ala Asn Arg Ile Leu Asp Glu Thr Ala Glu Gly Lys Leu Gln Phe 
    530                 535                 540                 


Ser Ala Leu Phe Pro Glu Met Arg His Arg Phe Ile Pro Pro Gln Asn 
545                 550                 555                 560 


Pro Lys Ser Lys Asp Arg Arg Glu Lys Ala Glu Thr Thr Leu Glu Lys 
                565                 570                 575     


Tyr Lys Gln Glu Ile Lys Gly Arg Lys Asp Lys Leu Asn Ser Gln Leu 
            580                 585                 590         


Leu Ser Ala Phe Asp Met Asp Gln Arg Gln Leu Pro Ser Arg Leu Leu 
        595                 600                 605             


Asp Glu Trp Met Asn Ile Arg Pro Ala Ser His Ser Val Lys Leu Arg 
    610                 615                 620                 


Thr Tyr Val Lys Gln Leu Asn Glu Asp Cys Arg Leu Arg Leu Gln Lys 
625                 630                 635                 640 


Phe Arg Lys Asp Gly Asp Gly Lys Ala Arg Ala Ile Pro Leu Val Gly 
                645                 650                 655     


Glu Met Ala Thr Phe Leu Ser Gln Asp Ile Val Arg Met Ile Ile Ser 
            660                 665                 670         


Glu Glu Thr Lys Lys Leu Ile Thr Ser Ala Tyr Tyr Asn Glu Met Gln 
        675                 680                 685             


Arg Ser Leu Ala Gln Tyr Ala Gly Glu Glu Asn Arg His Gln Phe Arg 
    690                 695                 700                 


Ala Ile Val Ala Glu Leu Arg Leu Leu Asp Pro Ser Ser Gly His Pro 
705                 710                 715                 720 


Phe Leu Ser Ala Thr Met Glu Thr Ala His Arg Tyr Thr Glu Asp Phe 
                725                 730                 735     


Tyr Lys Cys Tyr Leu Glu Lys Lys Arg Glu Trp Leu Ala Lys Thr Phe 
            740                 745                 750         


Tyr Arg Pro Glu Gln Asp Glu Asn Thr Lys Arg Arg Ile Ser Val Phe 
        755                 760                 765             


Phe Val Pro Asp Gly Glu Ala Arg Lys Leu Leu Pro Leu Leu Ile Arg 
    770                 775                 780                 


Arg Arg Met Lys Glu Gln Asn Asp Leu Gln Asp Trp Ile Arg Asn Lys 
785                 790                 795                 800 


Gln Ala His Pro Ile Asp Leu Pro Ser His Leu Phe Asp Ser Lys Val 
                805                 810                 815     


Met Glu Leu Leu Lys Val Lys Asp Gly Lys Lys Lys Trp Asn Glu Ala 
            820                 825                 830         


Phe Lys Asp Trp Trp Ser Thr Lys Tyr Pro Asp Gly Met Gln Pro Phe 
        835                 840                 845             


Tyr Gly Leu Arg Arg Glu Leu Asn Ile His Gly Lys Ser Val Ser Tyr 
    850                 855                 860                 


Ile Pro Ser Asp Gly Lys Lys Phe Ala Asp Cys Tyr Thr His Leu Met 
865                 870                 875                 880 


Glu Lys Thr Val Arg Asp Lys Lys Arg Glu Leu Arg Thr Ala Gly Lys 
                885                 890                 895     


Pro Val Pro Pro Asp Leu Ala Ala Tyr Ile Lys Arg Ser Phe His Arg 
            900                 905                 910         


Ala Val Asn Glu Arg Glu Phe Met Leu Arg Leu Val Gln Glu Asp Asp 
        915                 920                 925             


Arg Leu Met Leu Met Ala Ile Asn Lys Ile Met Thr Asp Arg Glu Glu 
    930                 935                 940                 


Asp Ile Leu Pro Gly Leu Lys Asn Ile Asp Ser Ile Leu Asp Lys Glu 
945                 950                 955                 960 


Asn Gln Phe Ser Leu Ala Val His Ala Lys Val Leu Glu Lys Glu Gly 
                965                 970                 975     


Glu Gly Gly Asp Asn Ser Leu Ser Leu Val Pro Ala Thr Ile Glu Ile 
            980                 985                 990         


Lys Ser Lys Arg Lys Asp Trp Ser  Lys Tyr Ile Arg Tyr  Arg Tyr Asp 
        995                 1000                 1005             


Arg Arg  Val Pro Gly Leu Met  Ser His Phe Pro Glu  His Lys Ala 
    1010                 1015                 1020             


Thr Leu  Asp Glu Val Lys Thr  Leu Leu Gly Glu Tyr  Asp Arg Cys 
    1025                 1030                 1035             


Arg Ile  Lys Ile Phe Asp Trp  Ala Phe Ala Leu Glu  Gly Ala Ile 
    1040                 1045                 1050             


Met Ser  Asp Arg Asp Leu Lys  Pro Tyr Leu His Glu  Ser Ser Ser 
    1055                 1060                 1065             


Arg Glu  Gly Lys Ser Gly Glu  His Ser Thr Leu Val  Lys Met Leu 
    1070                 1075                 1080             


Val Glu  Lys Lys Gly Cys Leu  Thr Pro Asp Glu Ser  Gln Tyr Leu 
    1085                 1090                 1095             


Ile Leu  Ile Arg Asn Lys Ala  Ala His Asn Gln Phe  Pro Cys Ala 
    1100                 1105                 1110             


Ala Glu  Ile Pro Leu Ile Tyr  Arg Asp Val Ser Ala  Lys Val Gly 
    1115                 1120                 1125             


Ser Ile  Glu Gly Ser Ser Ala  Lys Asp Leu Pro Glu  Gly Ser Ser 
    1130                 1135                 1140             


Leu Val  Asp Ser Leu Trp Lys  Lys Tyr Glu Met Ile  Ile Arg Lys 
    1145                 1150                 1155             


Ile Leu  Pro Ile Leu Asp Pro  Glu Asn Arg Phe Phe  Gly Lys Leu 
    1160                 1165                 1170             


Leu Asn  Asn Met Ser Gln Pro  Ile Asn Asp Leu 
    1175                 1180                 


<210>  1600
<211>  1118
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1600

Met Thr Glu Gln Asn Glu Arg Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Phe Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Ala His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Cys Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Gly Thr Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Thr Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu His Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Leu Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Asp Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Asp Glu Ile Asn Thr Arg Asp 
    530                 535                 540                 


Glu Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Ile Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Ser Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


His Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys Ala 
    770                 775                 780                 


Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro Phe 
785                 790                 795                 800 


Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys Gly 
                805                 810                 815     


Arg Phe Leu Ser Lys Glu Asp Arg Ala Glu Glu Trp Glu Ser Gly Lys 
            820                 825                 830         


Glu Arg Phe Arg Leu Ala Lys Leu Lys Lys Glu Ile Leu Glu Ala Lys 
        835                 840                 845             


Glu His Pro Tyr Leu Asp Phe Lys Ser Trp Gln Lys Phe Glu Arg Glu 
    850                 855                 860                 


Leu Arg Leu Val Lys Asn Gln Asp Ile Ile Thr Trp Met Met Cys Arg 
865                 870                 875                 880 


Asp Leu Met Glu Glu Asn Lys Val Glu Gly Leu Asp Thr Gly Thr Leu 
                885                 890                 895     


Tyr Leu Lys Asp Ile Arg Thr Glu Val Gln Glu Gln Gly Ser Leu Asn 
            900                 905                 910         


Val Leu Asn Arg Val Lys Ser Met Arg Leu Pro Val Val Val Tyr Arg 
        915                 920                 925             


Ala Asp Ser Arg Gly His Val His Lys Glu Gln Ala Pro Leu Ala Thr 
    930                 935                 940                 


Val Tyr Ile Glu Glu Arg Asp Thr Lys Leu Leu Lys Gln Gly Asn Phe 
945                 950                 955                 960 


Lys Ser Phe Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Val 
                965                 970                 975     


Asp Thr Gly Gly Leu Ala Met Glu Gln Tyr Pro Ile Ser Lys Leu Arg 
            980                 985                 990         


Val Glu Tyr Glu Leu Ala Lys Tyr  Gln Thr Ala Arg Val  Cys Ala Phe 
        995                 1000                 1005             


Glu Gln  Met Leu Glu Leu Glu  Glu Ser Leu Leu Thr  Arg Tyr Pro 
    1010                 1015                 1020             


His Leu  Pro Asp Lys Asn Phe  Arg Lys Met Leu Glu  Ser Trp Ser 
    1025                 1030                 1035             


Asp Pro  Leu Leu Asp Lys Trp  Pro Asp Leu His Arg  Lys Val Arg 
    1040                 1045                 1050             


Leu Leu  Ile Ala Val Arg Asn  Ala Phe Ser His Asn  Gln Tyr Pro 
    1055                 1060                 1065             


Met Tyr  Asp Glu Ala Val Phe  Ser Ser Ile Arg Lys  Tyr Asp Pro 
    1070                 1075                 1080             


Ser Ser  Leu Asp Ala Ile Glu  Glu Arg Met Gly Leu  Asn Ile Ala 
    1085                 1090                 1095             


His Arg  Leu Ser Glu Glu Val  Lys Gln Ala Lys Glu  Met Val Glu 
    1100                 1105                 1110             


Arg Ile  Ile Gln Val 
    1115             


<210>  1601
<211>  1146
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1601

Met Glu Ser Ile Ile Gly Leu Gly Leu Ser Phe Asn Pro Tyr Lys Thr 
1               5                   10                  15      


Ala Asp Lys His Tyr Phe Gly Ser Phe Leu Asn Leu Ala Asp Asn Asn 
            20                  25                  30          


Leu Lys Ala Val Phe Ala Glu Phe Lys Glu Arg Ile Ser Asp Lys Ser 
        35                  40                  45              


Lys Asp Glu Asp Ile Ser Asn Leu Ile Glu Lys His Phe Ile Asp Asn 
    50                  55                  60                  


Met Ser Ile Val Asp Tyr Glu Lys Asn Ile Ser Ile Leu Asn Gly Tyr 
65                  70                  75                  80  


Leu Pro Ile Ile Asp Phe Leu Asp Asp Glu Leu Glu Asn Asn Leu Asn 
                85                  90                  95      


Thr Arg Val Lys Asn Phe Lys Lys Ser Phe Ile Ile Leu Ala Glu Ala 
            100                 105                 110         


Leu Glu Thr Leu Arg Asn Tyr Tyr Thr His Phe Tyr His Asp Pro Ile 
        115                 120                 125             


Thr Phe Gly Asp Asn Lys Glu Pro Leu Leu Glu Leu Leu Asp Glu Val 
    130                 135                 140                 


Leu Leu Lys Thr Ile Leu Asp Val Lys Lys Lys Tyr Leu Lys Thr Asp 
145                 150                 155                 160 


Lys Thr Lys Glu Ile Leu Lys Asp Ser Leu Arg Glu Glu Met Asp Leu 
                165                 170                 175     


Leu Val Ile Arg Lys Thr Asp Glu Leu Arg Glu Lys Lys Lys Thr Asn 
            180                 185                 190         


Pro Lys Phe Lys Phe Ser Thr Asp Pro Thr Gln Ile Arg Asn Ser Ile 
        195                 200                 205             


Phe Asn Asp Ala Phe Gln Gly Leu Leu Tyr Glu Asp Lys Glu Asn Asn 
    210                 215                 220                 


Gly Lys Thr Gln Val Ser Tyr Arg Ala Lys Thr Lys Leu Asn Pro Lys 
225                 230                 235                 240 


Asp Ile His Lys Gln Glu Glu Arg Asp Phe Glu Ile Pro Leu Ser Thr 
                245                 250                 255     


Ser Gly Ile Val Phe Leu Met Ser Leu Phe Leu Ser Lys Lys Glu Ile 
            260                 265                 270         


Glu Asp Phe Lys Ser Asn Ile Lys Gly Phe Lys Gly Lys Val Val Lys 
        275                 280                 285             


Asp Glu Asn His Asn Ser Leu Lys Tyr Met Ala Thr His Arg Val Tyr 
    290                 295                 300                 


Ser Ile Leu Ala Phe Lys Gly Leu Lys Tyr Arg Ile Lys Thr Asp Thr 
305                 310                 315                 320 


Phe Ser Lys Val Thr Leu Met Met Gln Met Ile Asp Glu Leu Ser Lys 
                325                 330                 335     


Val Pro Asp Cys Val Tyr Gln Asn Leu Ser Glu Thr Lys Gln Lys Asp 
            340                 345                 350         


Phe Ile Glu Asp Trp Asn Glu Tyr Leu Lys Asp Asn Glu Glu Asn Thr 
        355                 360                 365             


Glu Asn Leu Glu Asn Ser Arg Val Val His Pro Leu Ile Arg Lys Arg 
    370                 375                 380                 


Tyr Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe 
385                 390                 395                 400 


Ala Asn Phe Lys Thr Leu Lys Phe Gln Val Phe Met Gly Tyr Tyr Ile 
                405                 410                 415     


His Asp Gln Arg Thr Lys Thr Ile Gly Thr Thr Asn Ile Thr Thr Glu 
            420                 425                 430         


Arg Thr Val Lys Glu Lys Ile Asn Val Phe Gly Lys Leu Ser Lys Met 
        435                 440                 445             


Asp Asn Leu Lys Lys His Phe Phe Ser Gln Leu Ser Asp Glu Glu Asn 
    450                 455                 460                 


Thr Asp Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Phe Leu Thr Gln 
465                 470                 475                 480 


Ala Asp Asn Ser Pro Ala Asn Asn Ile Pro Ile Tyr Leu Glu Leu Lys 
                485                 490                 495     


Asn Gln Gln Ile Ile Lys Glu Lys Asp Asp Ile Lys Ala Glu Val Asn 
            500                 505                 510         


Asn Ser Gln Asn Arg Asn Pro Asn Lys Pro Ser Lys Arg Asp Leu Leu 
        515                 520                 525             


Asn Lys Ile Ser Asn Thr Asn Glu Asp Phe Tyr Gln Gly Asp Pro Thr 
    530                 535                 540                 


Ala Ile Leu Ser Leu Asn Glu Ile Pro Ala Leu Leu His Leu Phe Leu 
545                 550                 555                 560 


Val Gln Pro Asp Asn Lys Thr Gly Gln Gln Ile Glu Asn Ile Ile Arg 
                565                 570                 575     


Ile Lys Ile Glu Lys Gln Phe Asn Ser Ile Lys Asn Pro Ser Lys Asp 
            580                 585                 590         


Asp Lys Gly Val Pro Lys Ser Leu Phe Ala Asp Thr Asn Val Arg Val 
        595                 600                 605             


Asn Ala Ile Lys Leu Lys Lys Asp Leu Gly Glu Glu Leu Asp Met Leu 
    610                 615                 620                 


Asn Lys Lys Gln Ile Val Phe Lys Glu Asn Gln Lys Ala Ser Ser Asn 
625                 630                 635                 640 


Tyr Asp Glu Leu Leu Lys Lys His Gln Phe Thr Pro Lys Asn Lys Arg 
                645                 650                 655     


Pro Ala Leu Arg Lys Tyr Val Phe Tyr Asn Ser Glu Lys Gly Glu Glu 
            660                 665                 670         


Ala Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Lys Gly Phe 
        675                 680                 685             


Lys Thr Lys Trp Lys Gly Tyr Gln His Ser Glu Leu Gln Arg Lys Leu 
    690                 695                 700                 


Ala Phe Tyr Asp Arg His Thr Lys Gln Asp Ile Lys Glu Leu Leu Ser 
705                 710                 715                 720 


Gly Cys Glu Phe Asp His Phe Leu Leu Asp Ile Asn Ala Cys Phe Lys 
                725                 730                 735     


Glu Asp Asp Phe Glu Asp Phe Phe Ser Lys Tyr Leu Lys Asn Arg Ile 
            740                 745                 750         


Glu Thr Leu Asn Ile Ile Leu Lys Gln Leu His Asp Phe Lys Asn Glu 
        755                 760                 765             


Pro Thr Pro Leu Lys Gly Val Phe Lys Asn Cys Leu Lys Phe Leu Lys 
    770                 775                 780                 


Gln Lys Asn Tyr Val Thr Glu Asn Pro Glu Ile Ile Lys Lys Arg Ile 
785                 790                 795                 800 


Leu Ala Lys Pro Ala Phe Leu Pro Arg Gly Ile Phe Asp Glu Arg Pro 
                805                 810                 815     


Thr Met Lys Lys Gly Lys Asn Pro Leu Ile Asp Arg Asp Glu Phe Ala 
            820                 825                 830         


Lys Trp Phe Val Glu Tyr Leu Glu Asn Lys Asp Tyr Gln Lys Phe Tyr 
        835                 840                 845             


Asn Ser Glu Glu Tyr Arg Ile Arg Asp Ala Asp Phe Lys Lys Asn Ala 
    850                 855                 860                 


Val Ile Lys Lys Gln Lys Leu Lys Asp Phe Tyr Thr Leu Gln Met Val 
865                 870                 875                 880 


Asn Tyr Leu Leu Lys Glu Val Phe Gly Lys Asp Glu Met Asn Leu Gln 
                885                 890                 895     


Leu Ser Glu Leu Phe Gln Thr Arg Gln Glu Arg Leu Lys Leu Gln Gly 
            900                 905                 910         


Ile Ala Lys Lys Gln Met Asn Lys Glu Thr Gly Asp Ser Ser Glu Asn 
        915                 920                 925             


Thr Arg Asn Gln Thr Tyr Ile Trp Asn Lys Asp Val Pro Val Ser Phe 
    930                 935                 940                 


Phe Asn Gly Lys Val Thr Ile Asp Lys Val Lys Leu Lys Asn Ile Gly 
945                 950                 955                 960 


Lys Tyr Lys Arg Tyr Glu Arg Asp Glu Arg Val Lys Thr Phe Ile Gly 
                965                 970                 975     


Tyr Glu Val Asp Glu Lys Trp Met Met Tyr Leu Pro His Asn Trp Lys 
            980                 985                 990         


Asp Arg Tyr Ser Val Lys Pro Ile  Asn Val Ile Asp Leu  Gln Ile Gln 
        995                 1000                 1005             


Glu Tyr  Glu Glu Ile Arg Ser  His Glu Leu Leu Lys  Glu Ile Gln 
    1010                 1015                 1020             


Asn Leu  Glu Gln Tyr Ile Tyr  Asp His Thr Thr Asp  Lys Asn Thr 
    1025                 1030                 1035             


Leu Leu  Gln Asp Gly Asn Pro  Asn Phe Lys Met Tyr  Val Leu Asn 
    1040                 1045                 1050             


Gly Leu  Leu Thr Gly Ile Lys  Gln Val Asn Ile Ala  Asp Phe Ile 
    1055                 1060                 1065             


Val Leu  Lys Gln Asn Thr Asn  Phe Asp Lys Ile Asp  Phe Thr Gly 
    1070                 1075                 1080             


Ile Ala  Ser Cys Ser Glu Leu  Glu Lys Lys Thr Ile  Ile Leu Ile 
    1085                 1090                 1095             


Ala Ile  Arg Asn Lys Phe Ala  His Asn Gln Leu Pro  Asn Lys Thr 
    1100                 1105                 1110             


Ile Tyr  Asp Leu Ala Asn Glu  Phe Leu Lys Lys Glu  Lys Arg Glu 
    1115                 1120                 1125             


Thr Tyr  Ala Asn Tyr Tyr Leu  Lys Val Leu Lys Lys  Met Ile Ser 
    1130                 1135                 1140             


Asp Leu  Ala 
    1145     


<210>  1602
<211>  1000
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1602

Met Glu Glu Ala Asn Arg Tyr Ile Tyr Gly Ala Tyr Phe Asn Met Ala 
1               5                   10                  15      


Arg Asp Asn Phe Leu Asn Thr Ile Lys Leu Leu Ala Asp Lys Met Lys 
            20                  25                  30          


Leu Gly Ala Thr Ser Gly Phe Gly Lys Asp Gly Asn Glu Val Asn Asp 
        35                  40                  45              


Ile Asn Glu Leu Phe Gly Asp Lys Asn Thr Tyr Ala Asn Ile Glu Asn 
    50                  55                  60                  


Val Val Glu Phe Tyr Phe Pro Trp Ile Lys Ala Leu Glu Gly Arg Phe 
65                  70                  75                  80  


Ser Leu Asp Lys Gly Asp Arg Asn Leu Asn Asp Met Lys Met Phe Tyr 
                85                  90                  95      


Lys Ser Val Leu Thr Ala Phe Phe Thr Ala Val Asp Ser Leu Arg Asn 
            100                 105                 110         


Lys Tyr Thr His Tyr Ser His Lys Asp Leu Asn Ile Arg Glu Ile Lys 
        115                 120                 125             


Ile Glu Cys Thr Leu Gly Gly Lys Asp Tyr Cys Ile Gly Leu Leu Asn 
    130                 135                 140                 


Ala Leu Asp Cys Ile Tyr Asp Ser Ala Val Asn Leu Leu Lys Leu Arg 
145                 150                 155                 160 


Phe Met Ala Asp Glu Asp Glu Val Ala His Leu Arg Arg Cys Lys Ala 
                165                 170                 175     


Val Asn Lys Lys Val Val Val Arg Thr Glu Lys Asp Gly Phe Tyr Tyr 
            180                 185                 190         


Arg Leu Ser Asp Asn Gly Glu Val Thr Glu Lys Gly Val Ile Phe Ile 
        195                 200                 205             


Ala Ser Met Phe Leu Asn Arg Lys Tyr Gly Phe Leu Phe Leu Lys Gln 
    210                 215                 220                 


Leu Glu Gly Phe Lys Arg Ser Asp Glu Lys Arg Tyr Arg Leu Thr Leu 
225                 230                 235                 240 


Glu Ala Phe Leu Ala Phe Ser Asn Ile Lys Pro Val Asp Arg Leu Lys 
                245                 250                 255     


Ser Asp Lys Leu Asp Arg Ala Ser Leu Gly Leu Asp Met Leu Asn Glu 
            260                 265                 270         


Leu Thr Lys Ile Pro Lys Glu Leu Ser Glu Thr Leu Ser Val Asp Cys 
        275                 280                 285             


Leu Tyr Lys Tyr Leu Ala Ser Asp Gly Glu Asp Asp Leu Arg Ser Arg 
    290                 295                 300                 


Ile Arg Tyr Gln Asp Arg Phe Val Pro Leu Ala Leu Glu Phe Ile Ser 
305                 310                 315                 320 


Gln Ser Asp Glu Phe Lys Asp Phe Arg Phe Tyr Thr Tyr Val Gly Asn 
                325                 330                 335     


Tyr Val Tyr Lys Gly Tyr Ile Lys Arg Leu Ile Asp Gly Thr Asp Lys 
            340                 345                 350         


Glu Arg Tyr Leu Ser Asp Arg Leu Cys Gly Phe Tyr Lys Ser Val Asn 
        355                 360                 365             


Asp Ala Ser Ser Asp Ala Ile Ala Gln Lys Tyr Gly Val Glu Ile Lys 
    370                 375                 380                 


Asp Ser Asn Glu Pro Asp Tyr Met Leu Pro Asp Ser Phe Arg Pro His 
385                 390                 395                 400 


Val Leu Arg Ala Thr Pro His Phe Val Ile Asn Asn Asn Asn Ile Gly 
                405                 410                 415     


Ile Lys Ile Cys Gly Asn Asp Cys Leu Pro Val Val Asn Gly Lys Gly 
            420                 425                 430         


Val Glu Ser Pro Glu Pro Asp Tyr Trp Leu Ser Ile Tyr Glu Leu Pro 
        435                 440                 445             


Ala Met Leu Phe Tyr Ala Tyr Leu Arg Glu Lys Asn Gly Lys Leu Leu 
    450                 455                 460                 


Lys Asp Tyr Lys Ser Ile Arg Glu Leu Ile Glu Asp Val Glu Lys Lys 
465                 470                 475                 480 


Ala Asp Glu Lys Asn Asp Arg Asp Lys Gly Ala Leu Met Ala Arg His 
                485                 490                 495     


Ile Asp Lys Glu Ile Ile Trp Thr Gln Thr Lys Leu Asp Glu Val Lys 
            500                 505                 510         


Arg Leu Glu Glu Lys Lys Val Ala Ala Tyr Gly Lys Lys Gly Arg Val 
        515                 520                 525             


Val Leu Lys Ser Gly Arg Met Ala Asp Leu Leu Ala His Asp Met Val 
    530                 535                 540                 


Arg Leu Gln Pro Ala Thr Lys Gly Ser Asp Lys Ile Thr Gly Ala Asn 
545                 550                 555                 560 


Phe Gln Ala Leu Gln Val Ser Leu Ala Tyr Phe Lys Arg Asp Ile Leu 
                565                 570                 575     


Ala Asp Val Phe Ser Arg Ala Met Leu Thr Thr Gly Asn His Arg His 
            580                 585                 590         


Pro Phe Leu Tyr Arg Ile Asp Val Ser His Cys Ser Ser Leu Arg Asp 
        595                 600                 605             


Phe Tyr Val Ala Tyr Leu Gly Glu Arg Arg Lys Tyr Phe Glu Asp Val 
    610                 615                 620                 


Ala Lys Lys Ile Thr Lys Asn Lys Leu Asn Thr Pro Cys His Ile Leu 
625                 630                 635                 640 


Arg Arg Leu Gln Arg Glu Gly Ser Gly Glu Glu Ala Gly Lys Asp Val 
                645                 650                 655     


Lys Pro Lys Phe Leu Pro Arg Gly Ile Phe Thr Gly Ser Ile Lys Ser 
            660                 665                 670         


Cys Leu Glu Lys Ser Ala Leu Asn Ile Asn Ile Arg Asn Ala Arg Asn 
        675                 680                 685             


Asp Val Lys Pro Ala Ile Asn Ala Ala Tyr Leu Ile Phe Met Tyr Tyr 
    690                 695                 700                 


Lys Glu Ile Glu Lys Gly Glu Phe Gln Gly Phe Tyr Gly Glu Lys Arg 
705                 710                 715                 720 


Arg Tyr Asp Ile Leu Glu Glu Gly Lys Pro Leu Asp Leu Asp Glu Arg 
                725                 730                 735     


Lys Lys Ala Leu Ala Ser Ile Lys Pro Ala Lys Ile Asp Val Ser Glu 
            740                 745                 750         


Ala Asn Met Pro Met Ser Lys Glu Glu His Leu Met Arg Lys Arg Tyr 
        755                 760                 765             


His Ala Val Cys Asn Asn Glu Ser Ala Ile Arg Met Tyr Gln Val Gln 
    770                 775                 780                 


Asp Ile Leu Leu Leu Leu Met Ala Lys Asp Ile Phe Lys Lys Ala Leu 
785                 790                 795                 800 


Ser Glu Val Val Met Ser Lys Lys Ile Gly Leu Glu Asn Leu Asn Gly 
                805                 810                 815     


Ile Phe Asp Ala Pro Val Asn Phe Val Lys Asn Phe Asp Asn Ile Lys 
            820                 825                 830         


Leu Thr Ala Thr Gly Ile Lys Ile Lys Asp Tyr Gly Lys Val Cys Arg 
        835                 840                 845             


Leu Gly Thr Asp Phe Lys Phe Asn Ser Leu Ile Lys Ala Phe His Lys 
    850                 855                 860                 


Val Tyr Ser Lys Ser Val Glu Met Asp Tyr Ser Asp Tyr Leu Lys Glu 
865                 870                 875                 880 


Glu Glu Glu Phe Glu Lys Tyr Arg Leu Asn Met Val Lys Leu Cys Arg 
                885                 890                 895     


Glu Val Glu Arg Gly Ile Thr Glu Asp Leu His Leu Ser Leu Asp Gly 
            900                 905                 910         


Lys Ser His Leu Ser Phe Asn Asp Asp Val Ile Lys Ser Tyr Asn Asp 
        915                 920                 925             


Lys Tyr Asn Val Phe Asn Gly Asp Asp Leu Thr Phe Phe Ile Asn Ala 
    930                 935                 940                 


Arg Asn Met Phe Met His Gly Asp Tyr Lys Tyr Glu Cys Val Lys Tyr 
945                 950                 955                 960 


Val Val Ser Glu His Phe Lys Gly Ser Leu Asn Asp Val Ser Phe Ala 
                965                 970                 975     


Lys Glu Thr Tyr Gly His Phe Cys Asn Leu Leu Glu Ser Met Arg Lys 
            980                 985                 990         


Lys Thr Gly Leu Arg Ile Asp Ile  
        995                 1000 


<210>  1603
<211>  1146
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1603

Met Pro Cys Arg Lys Thr Gln Glu Val Val Pro Tyr Gln His Trp Thr 
1               5                   10                  15      


Asn Leu Asp Lys Lys Gly Lys Pro Met Ser Asn Asn Ile Thr Asp Gly 
            20                  25                  30          


Ser Arg Asn Asp Val Ser Arg Pro Pro Gln Glu Ile Asp Ile Gly Gly 
        35                  40                  45              


Ser Arg Met Arg Ala Leu Ala Glu Arg Leu Glu Ile Val Ile Pro Lys 
    50                  55                  60                  


Asp Lys Gly Thr Lys Lys Lys Lys Asp Glu Val Lys Tyr Phe Thr Leu 
65                  70                  75                  80  


Tyr Leu Asn Tyr Ala Val Ser Asn Leu Arg Glu Ile Thr Gly Ile Lys 
                85                  90                  95      


Gly Asp Asp Glu Thr Lys Ile Lys Gln Gln Leu Glu Ala Leu Ser Asp 
            100                 105                 110         


Glu Lys Met Gln Arg Leu Ala Asp Phe Leu Trp Ala Phe Arg Phe Asp 
        115                 120                 125             


Glu Pro Gln Arg Asp Phe Gly Ala Arg Arg Glu Lys Lys Phe Asp His 
    130                 135                 140                 


Asp Tyr Lys Arg Leu Ala Pro Leu Val Ala Leu Lys Phe Phe Ala Leu 
145                 150                 155                 160 


Arg Asn Tyr Phe Ala His Leu Asp Arg Asn Gly Asn Glu Ala Leu Val 
                165                 170                 175     


Cys Gly Arg Asp Met Tyr Val Leu Leu Glu Gly Ile Leu Arg Pro Lys 
            180                 185                 190         


Ala Glu Lys Lys Cys Met Gly Ala Gly Cys Gln Ala Gly Lys Leu Tyr 
        195                 200                 205             


Lys Met His Leu Leu Asn Leu Arg Gly Pro Arg Lys Pro Gln Gln Pro 
    210                 215                 220                 


Met Glu Ser Arg Lys Tyr Glu Phe Thr Arg Arg Gly Ile Met Phe Phe 
225                 230                 235                 240 


Val Cys Met Ala Leu Tyr Lys Asp Asp Ala Glu Glu Phe Leu Ser Cys 
                245                 250                 255     


Phe Ala Asp Met Arg Val Pro Asn Arg Arg Arg Asp Ser Ile Asp Gly 
            260                 265                 270         


Leu Ser Glu Ala Glu Val Glu Lys Leu Gly Arg Lys Lys Pro Thr Lys 
        275                 280                 285             


Arg Ala Phe Leu Lys Ala Phe Thr Phe Phe Ser Tyr Arg Arg Gly Arg 
    290                 295                 300                 


Val Ser Leu Asp Gly Glu Asp Ala Asn Phe Leu Asn Phe Ala Asn Ile 
305                 310                 315                 320 


Ile Gly Tyr Leu Asn Lys Val Pro Arg Ala Ser Phe Asp Tyr Leu Ser 
                325                 330                 335     


Leu Asp Thr Glu Lys Lys Leu Leu Ala Asp Leu Ala Ser Arg Ser Thr 
            340                 345                 350         


Glu Ser Glu Glu Asn Lys Leu Phe Lys Tyr Asp Leu Ser Lys Gln Ile 
        355                 360                 365             


Arg Ala Lys Asp Arg Phe Val Ser Leu Ala Ala Ala Trp Cys Glu Asp 
    370                 375                 380                 


Phe Asn Val Leu Pro Cys Leu Arg Phe Lys Arg Leu Asp Ile Thr Pro 
385                 390                 395                 400 


Ser Leu Gly Arg His Arg Tyr Leu Phe Gly Ala Glu Asn Asp Asn Ala 
                405                 410                 415     


Val His Leu Asp Arg His Tyr Ile Ile Glu Asp Gly Ala Ile Arg Phe 
            420                 425                 430         


Glu Trp Val Pro Thr Ala His Tyr Gly Asp Val Lys Val Gly His Leu 
        435                 440                 445             


Arg Ser Cys Ile Gly Glu Ala Glu Phe Arg Arg Leu Leu Phe Cys Ala 
    450                 455                 460                 


Leu Arg Lys Pro Ala Glu Thr Asn Ala Met Leu Asp Glu Tyr Phe Ala 
465                 470                 475                 480 


Ala Tyr His Lys Val Leu Glu Leu Met Leu Asp Ala Ser Asp Asn Glu 
                485                 490                 495     


Ser Arg Ser Ile Phe Ser Asn Ala Glu Leu Ala Glu Ala Val Gln Lys 
            500                 505                 510         


Val Ser Gly Leu Thr Leu Asp Glu Ile Gly Asp Asp Pro Glu Arg Leu 
        515                 520                 525             


Gln Pro Phe Phe Pro Lys Asn Leu Trp Arg Phe Phe Phe Ser Trp Asp 
    530                 535                 540                 


Ala Ala Gln Gly Asp Asp Asp Leu Arg Ala Asn Val Ala Ala Lys Ile 
545                 550                 555                 560 


Asp Gly Arg Ile Lys Trp Cys Ser Asp Phe Leu Val Arg Val Ala Asn 
                565                 570                 575     


Phe Arg Lys Trp Asn Ala Glu Asn Phe Trp Lys Ala Arg Asp Gln Arg 
            580                 585                 590         


Gly Pro Gln Gly Ala Cys Pro Lys Ala Met Leu Val Asn Pro Pro Arg 
        595                 600                 605             


Asn Cys Arg Val Ser Asp Ala Ser Cys Val Ala Arg Val Ile Ala Tyr 
    610                 615                 620                 


Leu Asp Tyr His Leu Ala Pro Asp Arg Lys Phe Arg Gln Leu Ser Leu 
625                 630                 635                 640 


Gly Glu Gln His Ser His Pro Gly Arg Ala Asp Thr His Asn Tyr Glu 
                645                 650                 655     


Tyr Gln Leu Val Gln Ser Ala Ile Gly Arg Tyr Ser Leu Asp Gln Ile 
            660                 665                 670         


Ser Ala Val Gly Gly Met Lys Asp Gly Lys Ala Lys Ser Gly Ile Val 
        675                 680                 685             


Leu Gln Leu Arg Pro Glu Leu Glu Leu Ser Ala Ala Arg Leu Lys Asp 
    690                 695                 700                 


Lys Val Ser Ala Leu His Asp Asn His Arg Ala Ser Met Gly Lys Ser 
705                 710                 715                 720 


Leu Arg Asn Ala Gln Arg Arg Gly Leu Val Thr Gly Phe Ala Tyr Met 
                725                 730                 735     


Glu Ala Glu Arg Ala Leu Lys Ser Lys Lys Leu Ile Asp Leu Ala Glu 
            740                 745                 750         


Ala Ala Ala Glu Leu Leu Lys Glu Glu Leu Leu Arg Glu Ala Glu Gly 
        755                 760                 765             


Leu Ala Ala Thr Ala Gly Asp Thr Leu Lys Ile Leu Cys Arg Lys Phe 
    770                 775                 780                 


Gly Val Arg Thr Gly Leu Pro Leu Asp Lys Asp Ala Leu Val Lys Thr 
785                 790                 795                 800 


Ile Leu Gly Ile Asp Met Asp Lys Trp Thr His Ala Phe Asp Tyr Gly 
                805                 810                 815     


His Gly His Pro Tyr Val Asp Arg Lys Leu Thr Glu Gly Glu His Val 
            820                 825                 830         


Ala Ala Gln Ile Pro Leu Pro Asn Gly Met Ala Glu Arg Val Met Arg 
        835                 840                 845             


Ser Gln Ser Arg Val Phe Gly Gly Leu Ile Gly Glu Ser Gly Val Asp 
    850                 855                 860                 


Trp Ala Lys Ala Phe Ala Ser Leu Asp Gly Arg Asp Val Ser Leu Leu 
865                 870                 875                 880 


Gly Phe Tyr Asp Val Ser Pro Leu Val Gly Tyr Ile Lys Ser His Pro 
                885                 890                 895     


Asn His Thr Asp Glu Tyr Pro Asp Pro Ser Ala Pro Gly Ile Asn Thr 
            900                 905                 910         


Trp Ala Asp Val Asp Pro Arg Ala Ile Lys Pro Asp Phe Ser Arg Gly 
        915                 920                 925             


Gly Ile Asn Asn Ala Ile Arg Ala Ile Lys Thr Ala Arg Asn Gln Asp 
    930                 935                 940                 


Arg Leu Leu Leu Lys Phe Ala Leu Gln Tyr Trp Glu Ala Phe Lys Lys 
945                 950                 955                 960 


Asn Arg Ala Tyr Asp Glu Arg Lys Thr Ala Tyr Glu Lys Ala Ile Thr 
                965                 970                 975     


Val Arg Asp Tyr Phe Asn Gly Thr Phe Thr Tyr Ala Leu Arg Gly Gly 
            980                 985                 990         


Val Gly Leu Arg Leu Ser Arg Asn  Asp Val Phe Ser Pro  Thr Phe Ala 
        995                 1000                 1005             


His Val  Val Glu Asn Ala Ala  Ala Ile Ser Glu Leu  Leu Arg Lys 
    1010                 1015                 1020             


Glu Asn  Pro Thr Ala Cys Glu  Phe Ser Phe Tyr Asp  Val Ala Gln 
    1025                 1030                 1035             


Leu Phe  Ala Arg Lys Gln Arg  Glu Ser Arg Asn Leu  Arg Met Glu 
    1040                 1045                 1050             


Leu Leu  Pro Asp Leu Glu Lys  Phe Ala Ala Arg Cys  Pro Val Pro 
    1055                 1060                 1065             


Gln Glu  Glu Tyr Ala Arg Ile  Asp Ala Gln Val Cys  Lys Glu Asn 
    1070                 1075                 1080             


Glu Arg  Arg Leu Ala Arg Arg  Ala Met Glu Tyr Ser  Tyr Tyr Ser 
    1085                 1090                 1095             


Lys Val  Met Pro Thr Leu Thr  Glu Ala Glu Tyr Asn  Leu Val Ala 
    1100                 1105                 1110             


Asp Val  Arg Asn Ala Val Met  His Ser Thr Leu Leu  Val Thr Asp 
    1115                 1120                 1125             


Asp Asp  Ala Tyr Arg Thr Ala  Lys Ala Val Leu Gly  Arg Phe Val 
    1130                 1135                 1140             


Ser Ala  Arg 
    1145     


<210>  1604
<211>  1121
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1604

Val Lys Lys Lys Glu Glu Glu Thr Pro Val Val Ser Thr Tyr Asn Lys 
1               5                   10                  15      


Asp Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Val Tyr Ile Thr Ile Asn His Ile Asn Lys Leu Leu Glu Ile Arg Glu 
        35                  40                  45              


Ile Asp Asn Asp Glu Lys Val Leu Asp Ile Lys Ala Leu Trp Gln Lys 
    50                  55                  60                  


Val Asn Lys Asp Leu Asn Gln Lys Ala Arg Leu Arg Glu Leu Met Thr 
65                  70                  75                  80  


Lys His Phe Pro Phe Leu Glu Thr Ala Ile Tyr Ser Lys Asn Lys Glu 
                85                  90                  95      


Asp Lys Glu Glu Val Lys Gln Glu Lys Gln Ala Thr Ala Gln Ser Phe 
            100                 105                 110         


Lys Ser Leu Glu His Cys Leu Phe Leu Phe Leu Glu Lys Leu Gln Glu 
        115                 120                 125             


Ala Arg Asn Tyr Tyr Ser His Tyr Lys Tyr Ser Glu Ser Thr Lys Glu 
    130                 135                 140                 


Pro Val Leu Glu Lys Glu Leu Leu Lys Lys Met Tyr Asn Ile Phe Asp 
145                 150                 155                 160 


Asn Asn Ile Gln Leu Val Ile Lys Asp Tyr Gln His Asn Lys Asp Ile 
                165                 170                 175     


Asn Pro Asp Glu Asp Phe Lys His Leu Asp Arg Thr Glu Lys Glu Phe 
            180                 185                 190         


Asn Tyr Tyr Phe Thr Gln Asp Lys Lys Gly Lys Ile Thr Glu Ser Gly 
        195                 200                 205             


Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp 
    210                 215                 220                 


Met Gln Gln Lys Leu Arg Gly Phe Lys Asp Asn Arg Glu Asn Asn Lys 
225                 230                 235                 240 


Gln Met Thr His Glu Val Phe Cys Arg Ser Arg Met Leu Leu Pro Lys 
                245                 250                 255     


Leu Arg Leu Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met 
            260                 265                 270         


Leu Asn Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Lys 
        275                 280                 285             


Gly Glu Asp Arg Lys Lys Phe Glu Val Pro Phe Asp Ser Thr Asp Glu 
    290                 295                 300                 


Asp Tyr Asp Ala Glu Gln Asp Pro Phe Lys Asn Thr Leu Ile Arg His 
305                 310                 315                 320 


Gln Asp Arg Phe Pro Tyr Phe Ile Leu Arg Tyr Phe Asp Tyr Asn Glu 
                325                 330                 335     


Ile Phe Lys Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe 
            340                 345                 350         


Ser Ile Tyr Lys Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg His Leu 
        355                 360                 365             


Thr His Lys Leu Tyr Gly Phe Glu Arg Ile Gln Glu Phe Thr Lys Gln 
    370                 375                 380                 


His Arg Pro Asp Asp Trp Lys Ala Ile Val Lys Asp Phe Asp Thr Tyr 
385                 390                 395                 400 


Glu Thr Ser Glu Glu Pro Tyr Ile Ser Glu Thr Thr Pro His Tyr His 
                405                 410                 415     


Leu Glu Asn Gln Lys Ile Gly Ile Arg Phe Lys Asn Asp Asn Asp Lys 
            420                 425                 430         


Ile Trp Pro Ser Leu Glu Thr Asn Gly Glu Asn Asn Glu Lys Ser Lys 
        435                 440                 445             


Tyr Lys Leu Asp Lys Gln Tyr Gln Ala Glu Ala Phe Leu Ser Val His 
    450                 455                 460                 


Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Lys Lys Glu Glu 
465                 470                 475                 480 


Pro Asn Asn Asp Lys Lys Asn Ala Ser Arg Val Glu Gly Phe Ile Lys 
                485                 490                 495     


Arg Glu Ile Arg Asp Ile Phe Lys Leu Tyr Asp Ala Phe Ala Asn Asp 
            500                 505                 510         


Glu Ile Asn Asn Ile Asp Asp Leu Lys Lys Tyr Cys Lys Asp Lys Asn 
        515                 520                 525             


Val Glu Ile Arg His Leu Pro Lys Gln Leu Ile Thr Ile Leu Glu Ser 
    530                 535                 540                 


Lys Pro Lys Asp Met Ala Lys Glu Ala Lys Arg Lys Gln Lys Glu Met 
545                 550                 555                 560 


Val Lys Asp Thr Lys Lys Leu Leu Ala Thr Leu Glu Lys Gln Thr Gln 
                565                 570                 575     


Lys Glu Lys Glu Asp Asp Gly Arg Asn Val Lys Leu Leu Lys Ser Gly 
            580                 585                 590         


Glu Ile Ala Arg Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Val 
        595                 600                 605             


Gln Lys Asp Asn Glu Gly Asn Pro Leu Asn Asn Ser Lys Ala Asn Ser 
    610                 615                 620                 


Thr Glu Tyr Gln Met Leu Gln Arg Ser Leu Ala Leu Tyr Asn Lys Glu 
625                 630                 635                 640 


Glu Lys Pro Thr Arg Tyr Phe Arg Gln Val Asn Leu Ile Asn Ser Ser 
                645                 650                 655     


Asn Pro His Pro Phe Leu Lys Trp Thr Lys Trp Glu Glu Cys Asn Asn 
            660                 665                 670         


Ile Leu Ser Phe Tyr Arg Ser Tyr Leu Thr Lys Lys Ile Glu Phe Leu 
        675                 680                 685             


Asn Lys Leu Lys Pro Glu Asp Trp Glu Lys Asn Gln Tyr Phe Leu Lys 
    690                 695                 700                 


Leu Lys Glu Pro Lys Thr Asn Arg Glu Thr Leu Val Gln Gly Trp Lys 
705                 710                 715                 720 


Asn Gly Phe Asn Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg Glu 
                725                 730                 735     


Trp Phe Lys Arg His Gln Asn Asp Ser Lys Glu Tyr Glu Lys Val Glu 
            740                 745                 750         


Ala Leu Lys Arg Val Gly Leu Val Thr Lys Val Ile Pro Leu Phe Phe 
        755                 760                 765             


Lys Glu Glu Tyr Phe Lys Glu Asp Ala Gln Lys Glu Ile Asn Asp Trp 
    770                 775                 780                 


Val Gln Pro Phe Tyr Ser Phe Pro Tyr Asn Val Gly Asn Ile His Lys 
785                 790                 795                 800 


Pro Lys Glu Glu Asp Phe Leu His Arg Glu Glu Arg Ile Glu Leu Trp 
                805                 810                 815     


Asp Lys Lys Lys Asp Lys Phe Lys Gly Tyr Lys Glu Lys Ile Lys Ser 
            820                 825                 830         


Lys Lys Leu Thr Glu Lys Glu Lys Glu Glu Phe Arg Ser Tyr Leu Glu 
        835                 840                 845             


Phe Gln Ser Trp Asn Lys Phe Glu Arg Glu Leu Arg Leu Val Arg Asn 
    850                 855                 860                 


Gln Asp Ile Val Thr Trp Leu Leu Cys Lys Glu Leu Ile Asp Lys Leu 
865                 870                 875                 880 


Lys Ile Asp Glu Leu Asn Ile Asp Glu Leu Lys Lys Leu His Leu Asn 
                885                 890                 895     


Asn Ile Asp Thr Asp Thr Ala Lys Lys Glu Lys Asn Asn Ile Leu Asn 
            900                 905                 910         


Arg Val Met Pro Met Glu Leu Pro Val Thr Val Tyr Lys Val Asn Lys 
        915                 920                 925             


Ala Gly Asn Ile Ile Lys Asn Lys Pro Leu His Thr Ile Tyr Ile Lys 
    930                 935                 940                 


Glu Ser Lys Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu Val 
945                 950                 955                 960 


Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Val Lys Thr Asn Ser 
                965                 970                 975     


Glu Ala Glu Ser Lys Arg Asn Pro Ile Ser Lys Leu Arg Val Glu His 
            980                 985                 990         


Glu Leu Arg Glu Tyr Gln Lys Ala  Arg Ile Glu Ile Ile  Lys Asp Met 
        995                 1000                 1005             


Leu Ala  Leu Glu Lys Thr Leu  Ile Asp Asn Tyr Asn  Ser Leu Asp 
    1010                 1015                 1020             


Thr Asp  Asn Phe His Asn Met  Leu Thr Gly Trp Leu  Glu Leu Lys 
    1025                 1030                 1035             


Gly Glu  Val Asn Lys Ala Lys  Phe Asn Asn Asp Val  Lys Leu Leu 
    1040                 1045                 1050             


Thr Ala  Val Arg Asn Ala Phe  Ser His Asn Gln Tyr  Pro Met Tyr 
    1055                 1060                 1065             


Asp Glu  Asn Leu Phe Val Asn  Ile Glu Arg Phe Ser  Leu Ser Ser 
    1070                 1075                 1080             


Ser Lys  Ile Leu Glu Ser Lys  Gly Leu Ser Ile Ala  Val Lys Leu 
    1085                 1090                 1095             


Lys Glu  Glu Val Ser Lys Ile  Val Lys Lys Ile Gln  Glu Glu Glu 
    1100                 1105                 1110             


Asp Gly  Lys Lys Glu Lys Glu  Thr 
    1115                 1120     


<210>  1605
<211>  1146
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1605

Met Glu Ser Ile Ile Gly Leu Gly Leu Ser Phe Asn Pro Tyr Lys Thr 
1               5                   10                  15      


Ala Asp Lys His Tyr Phe Gly Ser Phe Leu Asn Leu Ala Asp Asn Asn 
            20                  25                  30          


Leu Lys Ala Val Phe Ala Glu Phe Lys Glu Arg Ile Ser Asp Lys Ser 
        35                  40                  45              


Lys Asp Glu Asp Ile Ser Asn Leu Ile Glu Lys His Phe Ile Asp Asn 
    50                  55                  60                  


Met Ser Ile Val Asp Tyr Glu Lys Asn Ile Ser Ile Leu Asn Gly Tyr 
65                  70                  75                  80  


Leu Pro Ile Ile Asp Phe Leu Asp Asp Glu Leu Glu Asn Asn Leu Asn 
                85                  90                  95      


Thr Arg Val Lys Asn Phe Lys Lys Ser Phe Ile Ile Leu Ala Glu Ala 
            100                 105                 110         


Leu Glu Thr Leu Arg Asn Tyr Tyr Thr His Phe Tyr His Asp Pro Ile 
        115                 120                 125             


Thr Phe Gly Asp Asn Lys Glu Pro Leu Leu Glu Leu Leu Asp Glu Val 
    130                 135                 140                 


Leu Leu Lys Thr Ile Leu Asp Val Lys Lys Lys Tyr Leu Lys Thr Asp 
145                 150                 155                 160 


Lys Thr Lys Glu Ile Leu Lys Asp Ser Leu Arg Glu Glu Met Asp Leu 
                165                 170                 175     


Leu Val Ile Arg Lys Thr Asp Glu Leu Arg Glu Lys Lys Lys Thr Asn 
            180                 185                 190         


Pro Lys Phe Lys Phe Ser Thr Asp Pro Thr Gln Ile Arg Asn Ser Ile 
        195                 200                 205             


Phe Asn Asp Ala Phe Gln Gly Leu Leu Tyr Glu Asp Lys Glu Asn Asn 
    210                 215                 220                 


Gly Lys Thr Gln Val Ser Tyr Arg Ala Lys Thr Lys Leu Asn Pro Lys 
225                 230                 235                 240 


Asp Ile His Lys Gln Glu Glu Arg Asp Phe Glu Ile Pro Leu Ser Thr 
                245                 250                 255     


Ser Gly Ile Val Phe Leu Met Ser Leu Phe Leu Ser Lys Lys Glu Ile 
            260                 265                 270         


Glu Asp Phe Lys Ser Asn Ile Lys Gly Phe Lys Gly Lys Val Val Lys 
        275                 280                 285             


Asp Glu Asn His Asn Ser Leu Lys Tyr Met Ala Thr His Arg Val Tyr 
    290                 295                 300                 


Ser Ile Leu Ala Phe Lys Gly Leu Lys Tyr Arg Ile Lys Thr Asp Thr 
305                 310                 315                 320 


Phe Ser Lys Val Thr Leu Met Met Gln Met Ile Asp Glu Leu Ser Lys 
                325                 330                 335     


Val Pro Asp Cys Val Tyr Gln Asn Leu Ser Glu Thr Lys Gln Lys Asp 
            340                 345                 350         


Phe Ile Glu Asp Trp Asn Glu Tyr Leu Lys Asp Asn Glu Glu Asn Thr 
        355                 360                 365             


Glu Asn Leu Glu Asn Ser Arg Val Val His Pro Leu Ile Arg Lys Arg 
    370                 375                 380                 


Tyr Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe 
385                 390                 395                 400 


Ala Asn Phe Lys Thr Leu Lys Phe Gln Val Phe Met Gly Tyr Tyr Ile 
                405                 410                 415     


His Asp Gln Arg Thr Lys Thr Ile Gly Thr Thr Asn Ile Thr Thr Glu 
            420                 425                 430         


Arg Thr Val Lys Glu Lys Ile Asn Val Phe Gly Lys Leu Ser Lys Met 
        435                 440                 445             


Asp Asn Leu Lys Lys His Phe Phe Ser Gln Leu Ser Asp Glu Glu Asn 
    450                 455                 460                 


Thr Asp Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Phe Leu Thr Gln 
465                 470                 475                 480 


Ala Asp Asn Ser Pro Ala Asn Asn Ile Pro Ile Tyr Leu Glu Leu Lys 
                485                 490                 495     


Asn Gln Gln Ile Ile Lys Glu Lys Asp Asp Ile Lys Ala Glu Val Asn 
            500                 505                 510         


Asn Ser Gln Asn Arg Asn Pro Asn Lys Pro Ser Lys Arg Asp Leu Leu 
        515                 520                 525             


Asn Lys Ile Ser Asn Thr Asn Glu Asp Phe Tyr Gln Gly Asp Pro Thr 
    530                 535                 540                 


Ala Ile Leu Ser Leu Asn Glu Ile Pro Ala Leu Leu His Leu Phe Leu 
545                 550                 555                 560 


Val Gln Pro Asp Asn Lys Thr Gly Gln Gln Ile Glu Asn Ile Ile Arg 
                565                 570                 575     


Ile Lys Ile Glu Lys Gln Phe Asn Ser Ile Lys Asn Pro Ser Lys Asp 
            580                 585                 590         


Asp Lys Gly Val Pro Lys Ser Leu Phe Ala Asp Thr Asn Val Arg Val 
        595                 600                 605             


Asn Ala Ile Lys Leu Lys Lys Asp Leu Gly Glu Glu Leu Asp Met Leu 
    610                 615                 620                 


Asn Lys Lys Gln Ile Val Phe Lys Glu Asn Gln Lys Ala Ser Ser Asn 
625                 630                 635                 640 


Tyr Asp Glu Leu Leu Lys Lys His Gln Phe Thr Pro Lys Asn Lys Arg 
                645                 650                 655     


Pro Ala Leu Arg Lys Tyr Val Phe Tyr Asn Ser Glu Lys Gly Glu Glu 
            660                 665                 670         


Ala Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Lys Gly Phe 
        675                 680                 685             


Lys Thr Lys Trp Lys Gly Tyr Gln His Ser Glu Leu Gln Arg Lys Leu 
    690                 695                 700                 


Ala Phe Tyr Asp Arg His Thr Lys Gln Asp Ile Lys Glu Leu Leu Ser 
705                 710                 715                 720 


Gly Cys Glu Phe Asp His Phe Leu Leu Asp Ile Asn Ala Cys Phe Lys 
                725                 730                 735     


Glu Asp Asp Phe Glu Asp Phe Phe Ser Lys Tyr Leu Lys Asn Arg Ile 
            740                 745                 750         


Glu Thr Leu Asn Ile Ile Leu Lys Gln Leu His Asp Phe Lys Asn Glu 
        755                 760                 765             


Pro Thr Pro Leu Lys Gly Val Phe Lys Asn Cys Leu Lys Phe Leu Lys 
    770                 775                 780                 


Gln Lys Asn Tyr Val Thr Glu Asn Pro Glu Ile Ile Lys Lys Arg Ile 
785                 790                 795                 800 


Leu Ala Lys Pro Ala Phe Leu Pro Arg Gly Ile Phe Asp Glu Arg Pro 
                805                 810                 815     


Thr Met Lys Lys Gly Lys Asn Pro Leu Ile Asp Arg Asp Glu Phe Ala 
            820                 825                 830         


Lys Trp Phe Val Glu Tyr Leu Glu Asn Lys Asp Tyr Gln Lys Phe Tyr 
        835                 840                 845             


Asn Ser Glu Glu Tyr Arg Ile Arg Asp Ala Asp Phe Lys Lys Asn Ala 
    850                 855                 860                 


Val Ile Lys Lys Gln Lys Leu Lys Asp Phe Tyr Thr Leu Gln Met Val 
865                 870                 875                 880 


Asn Tyr Leu Leu Lys Glu Val Phe Gly Lys Asp Glu Met Asn Leu Gln 
                885                 890                 895     


Leu Ser Glu Leu Phe Gln Thr Arg Gln Glu Arg Leu Lys Leu Gln Gly 
            900                 905                 910         


Ile Ala Lys Lys Gln Met Asn Lys Glu Thr Gly Asp Ser Ser Glu Asn 
        915                 920                 925             


Thr Arg Asn Gln Thr Tyr Ile Trp Asn Lys Asp Val Pro Val Ser Phe 
    930                 935                 940                 


Phe Asn Gly Lys Val Thr Ile Asp Lys Val Lys Leu Lys Asn Ile Gly 
945                 950                 955                 960 


Lys Tyr Lys Arg Tyr Glu Arg Asp Glu Arg Val Lys Thr Phe Ile Gly 
                965                 970                 975     


Tyr Glu Val Asp Glu Lys Trp Met Met Tyr Leu Pro His Asn Trp Lys 
            980                 985                 990         


Asp Arg Tyr Ser Val Lys Pro Ile  Asn Val Ile Asp Leu  Gln Ile Gln 
        995                 1000                 1005             


Glu Tyr  Glu Glu Ile Arg Ser  His Glu Leu Leu Lys  Glu Ile Gln 
    1010                 1015                 1020             


Asn Leu  Glu Gln Tyr Ile Tyr  Asp His Thr Thr Asp  Lys Asn Thr 
    1025                 1030                 1035             


Leu Leu  Gln Asp Gly Asn Pro  Asn Phe Lys Met Tyr  Val Leu Asn 
    1040                 1045                 1050             


Gly Leu  Leu Thr Gly Ile Lys  Gln Val Asn Ile Ala  Asp Phe Ile 
    1055                 1060                 1065             


Val Leu  Lys Gln Asn Thr Asn  Phe Asp Lys Ile Asp  Phe Thr Gly 
    1070                 1075                 1080             


Ile Ala  Ser Cys Ser Glu Leu  Glu Lys Lys Thr Ile  Ile Leu Ile 
    1085                 1090                 1095             


Ala Ile  Arg Asn Lys Phe Ala  His Asn Gln Leu Pro  Asn Lys Thr 
    1100                 1105                 1110             


Ile Tyr  Asp Leu Ala Asn Glu  Phe Leu Lys Lys Glu  Lys Arg Glu 
    1115                 1120                 1125             


Thr Tyr  Ala Asn Tyr Tyr Leu  Lys Val Leu Lys Lys  Met Ile Ser 
    1130                 1135                 1140             


Asp Leu  Ala 
    1145     


<210>  1606
<211>  1057
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1606

Met Thr Ile Lys Glu Gln Ser His Phe Ala Ala Tyr Tyr Asn Met Ala 
1               5                   10                  15      


Arg His Asn Met Tyr Glu Thr Leu Cys Tyr Ile Ser Lys Ile Ser Gly 
            20                  25                  30          


Ile Gln Glu Gly Glu Asp Asn Lys Glu Ser Lys Ile Glu Asp Met Gln 
        35                  40                  45              


Leu Leu Arg Val Leu Thr Thr Lys Gly His Pro Glu Glu Lys Ile Arg 
    50                  55                  60                  


Ile Glu Lys Leu Ile Tyr Lys His Leu Pro Leu Phe Arg Pro Ala Val 
65                  70                  75                  80  


Glu Asp Leu Arg Lys Lys Ser Lys Glu Asn Val Lys Ser Pro Glu Leu 
                85                  90                  95      


Leu Ala Lys Val Ile Lys Asn Trp Ala Lys Val Ile Thr Tyr Tyr Arg 
            100                 105                 110         


Asp Lys Phe Thr His Tyr Val Phe Ile Asp Lys Arg His Glu Asn Lys 
        115                 120                 125             


Glu Phe Leu Asn Ala Glu Met Ser Val Ala Asn Asp Leu Asn Gln Ile 
    130                 135                 140                 


Phe Thr Ala Ser Ala Arg Val Ile Lys Glu Arg Phe Gly Leu Ser Thr 
145                 150                 155                 160 


Glu Leu Glu Phe Leu Thr Lys Gly Arg Tyr Arg Thr Gln Thr Ile Asp 
                165                 170                 175     


Gly Lys Arg Ser Thr Lys Leu Asn Pro Asn Phe Ile Tyr Ser Leu Gln 
            180                 185                 190         


Asp Lys Asn Glu Arg Leu Asn Lys Met Gly Leu Ile Phe Leu Ala Cys 
        195                 200                 205             


Gln Leu Ile Glu Lys Lys Tyr Ala Ser Met Leu Phe Asp Gln Gln Gly 
    210                 215                 220                 


Tyr Met Gly Arg Asp Ile Tyr Phe Asp Phe Thr Pro Ala Gln Cys Lys 
225                 230                 235                 240 


Tyr Ile Arg Glu Val Phe Ser Ala His Arg Ile Val Leu Pro Arg Gly 
                245                 250                 255     


Arg Met Asp Val Glu Arg Asn Glu Ile Thr Ile Ala Met Asp Met Phe 
            260                 265                 270         


Asn Glu Leu Gly Lys Cys Pro Lys Glu Leu Phe Glu Ile Ile Ser Lys 
        275                 280                 285             


Glu Glu Gln Lys Arg Phe Arg Thr Lys Ser Glu Thr Thr Gly Glu Glu 
    290                 295                 300                 


Val Leu Leu Met Arg His Ser Asp Arg Phe Ala Thr Leu Ala Leu Gln 
305                 310                 315                 320 


Tyr Ile Asp Asn Arg Lys Val Phe Glu Lys Ile Arg Phe Gln Leu Ser 
                325                 330                 335     


Leu Gly Lys Tyr Arg Tyr Lys Phe Tyr Asp Lys Thr Cys Val Asp Gly 
            340                 345                 350         


Asp Thr His Val Arg Ile Leu Gln Lys Glu Leu Asn Gly Phe Gly Arg 
        355                 360                 365             


Ile Asn Glu Ile Glu Leu Leu Lys Glu Glu Lys Trp Gly Gly Leu Ile 
    370                 375                 380                 


Arg Lys Phe Glu Asp Ala Lys Ile Asp Thr Ala Glu Thr Lys Pro Tyr 
385                 390                 395                 400 


Ile Thr Asp Gln Tyr Pro Gln Tyr Leu Phe Asn Gly Asn Arg Ile Gly 
                405                 410                 415     


Ile Tyr Phe Asn Ser Ala His Gly Lys Ala Met Arg Asn Gly Ala Tyr 
            420                 425                 430         


Ile Pro Asp Ile Glu Ser Gly Ala His Cys Ile Gln Pro Ile Cys Trp 
        435                 440                 445             


Ile Ser Asn Tyr Glu Leu Pro Ala Leu Ile Phe His His Ile Leu Thr 
    450                 455                 460                 


Lys Asp Glu Lys Lys Ser Leu Thr Glu Lys Ile Ile Ile Asp Cys Val 
465                 470                 475                 480 


Glu Arg Tyr Lys Lys Leu Phe Asn Asp Ile Ala Glu Gly Lys Val Ala 
                485                 490                 495     


Arg Thr Gly Asn Ala Thr Ser Asp Phe Glu Met Ile Ser Lys Glu Tyr 
            500                 505                 510         


Gly Ile Glu Lys Ser Asp Ile Pro Arg Glu Leu Gln Asp Tyr Phe Asn 
        515                 520                 525             


Gly Thr Glu Arg Asp Gly Ile Glu Gln Tyr Ala Lys Ala Gln Ile Arg 
    530                 535                 540                 


Glu Met Ile Glu Glu Asn Arg Ile Arg Leu Glu Gln Phe Asn Ser Lys 
545                 550                 555                 560 


Leu Lys Lys Ile Glu Asp Gly Glu Val Lys Tyr Gly Lys Arg Asp Tyr 
                565                 570                 575     


Thr Glu Ile Arg Thr Gly Glu Leu Ala Gln Tyr Leu Ala Lys Asp Ile 
            580                 585                 590         


Val Met Phe Met Pro Lys Ala Lys Tyr Lys Pro Thr Ser Lys Asn Tyr 
        595                 600                 605             


Asn Val Met Gln Ala Leu Leu Ala Thr Phe Asn Gly Ser Glu Ser Gly 
    610                 615                 620                 


Ser Thr Leu Asp Glu Val Asp Asp Met Phe Asp Asn Ile Lys Ala Cys 
625                 630                 635                 640 


Tyr Trp Lys Asn Glu Ser Asp Asn His Pro Phe Leu Glu Tyr Val Leu 
                645                 650                 655     


Gly Glu Glu Pro Lys Asp Ile Ile Ala Phe Tyr Lys Ile Tyr Leu Glu 
            660                 665                 670         


Leu Arg Gly Glu Tyr Leu Asp Lys Cys Ile Lys Lys Met Asp Leu Ala 
        675                 680                 685             


Thr Ile Pro Phe Ile His Thr Glu Arg Lys Arg Trp Glu Lys Arg Asp 
    690                 695                 700                 


Glu Lys Phe Phe Lys Glu Leu Ala Gln Arg Tyr Ala Thr Gln Pro Ile 
705                 710                 715                 720 


Glu Leu Pro Arg Gly Leu Tyr Asp Arg Ala Ile Lys Glu Tyr Leu Lys 
                725                 730                 735     


Ser Lys Ser Ile Leu Glu Asp Val Ile Ala Gln Glu Gln Cys Asn Val 
            740                 745                 750         


Thr Tyr Leu Ile Ala Arg Tyr Met Gln Asp Val Leu Lys Asp Asp Ser 
        755                 760                 765             


Gln Gln Phe Tyr Ser Leu Pro Arg His Tyr Ser Cys Leu Ser Glu Lys 
    770                 775                 780                 


Asp Lys Tyr Leu Ser Leu Thr Glu Arg Glu Ala Ile Ala Lys Ser Asp 
785                 790                 795                 800 


Ala Leu Asn Ser Phe Lys Lys Arg Glu Arg Glu Lys Glu Asn Glu Asn 
                805                 810                 815     


Arg Arg Gly Asn Arg Arg Tyr Asn Lys Gly Glu Asn Lys Asn Thr Ile 
            820                 825                 830         


Lys Asp Arg Asp Thr Glu Glu Lys Phe Asn Ser Leu Tyr Arg Lys Met 
        835                 840                 845             


Asp Asn Asn Glu Arg Ile Leu Arg Arg Tyr Lys Val Gln Asp Met Leu 
    850                 855                 860                 


Leu Tyr Leu Leu Ala Cys Asp Ile Ile Lys Gly Ile Met Arg Glu Asp 
865                 870                 875                 880 


Phe Gly Tyr Lys Leu Ser Met Ile Thr Asp Gly Lys Asn Ser Asn Phe 
                885                 890                 895     


Phe Asp Tyr Lys Met Pro Glu Phe Lys Thr Thr Ile Thr Leu Lys Glu 
            900                 905                 910         


Gly Lys Lys Phe Thr Ile Lys Gln Gln Tyr Leu Lys Ile Lys Asn Tyr 
        915                 920                 925             


Gly Asp Phe Leu Lys Phe Ile Phe Asp Leu Arg Ile Asp Ser Leu Leu 
    930                 935                 940                 


Ser Asn Gly Thr Lys Val Glu Ile Asp Arg Asn Ile Leu Glu Asp Glu 
945                 950                 955                 960 


Leu Ser Asn Tyr Asp Gly Ser Arg Pro Lys Val Phe Glu Thr Leu Leu 
                965                 970                 975     


Met Ile Glu Lys Ile Val Val Glu Lys His Lys Glu Leu Lys Asp Leu 
            980                 985                 990         


Glu His Ile Thr Phe Gly Asp Val  Leu Asn Val Ile Lys  Met Glu Glu 
        995                 1000                 1005             


Gly Glu  Lys Lys Ile Leu Arg  Leu Ile Arg Asn Ala  Phe Ser His 
    1010                 1015                 1020             


Asn Tyr  Tyr Pro Thr Ile Lys  Asp Val Asn Tyr Asp  Asn Met Pro 
    1025                 1030                 1035             


Glu Val  Ala Glu Ser Leu Lys  Asp Ile Leu Glu Lys  Glu Ser Lys 
    1040                 1045                 1050             


Lys Leu  Thr Asn 
    1055         


<210>  1607
<211>  1146
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1607

Met Glu Ser Ile Ile Gly Leu Gly Leu Ser Phe Asn Pro Tyr Lys Thr 
1               5                   10                  15      


Ala Asp Lys His Tyr Phe Gly Ser Phe Leu Asn Leu Ala Asp Asn Asn 
            20                  25                  30          


Leu Lys Ala Val Phe Ala Glu Phe Lys Glu Arg Ile Ser Asp Lys Ser 
        35                  40                  45              


Lys Asp Glu Asp Ile Ser Asn Leu Ile Glu Lys His Phe Ile Asp Asn 
    50                  55                  60                  


Met Ser Ile Val Asp Tyr Glu Lys Asn Ile Ser Ile Leu Asn Gly Tyr 
65                  70                  75                  80  


Leu Pro Ile Ile Asp Phe Leu Asp Asp Glu Leu Glu Asn Asn Leu Asn 
                85                  90                  95      


Thr Arg Val Lys Asn Phe Lys Lys Ser Phe Ile Ile Leu Ala Glu Ala 
            100                 105                 110         


Leu Glu Thr Leu Arg Asn Tyr Tyr Thr His Phe Tyr His Asp Pro Ile 
        115                 120                 125             


Thr Phe Gly Asp Asn Lys Glu Pro Leu Leu Glu Leu Leu Asp Glu Val 
    130                 135                 140                 


Leu Leu Lys Thr Ile Leu Asp Val Lys Lys Lys Tyr Leu Lys Thr Asp 
145                 150                 155                 160 


Lys Thr Lys Glu Ile Leu Lys Asp Ser Leu Arg Glu Glu Met Asp Leu 
                165                 170                 175     


Leu Val Ile Arg Lys Thr Asp Glu Leu Arg Glu Lys Lys Lys Thr Asn 
            180                 185                 190         


Pro Lys Phe Lys Phe Ser Thr Asp Pro Thr Gln Ile Arg Asn Ser Ile 
        195                 200                 205             


Phe Asn Asp Ala Phe Gln Gly Leu Leu Tyr Glu Asp Lys Glu Asn Asn 
    210                 215                 220                 


Gly Lys Thr Gln Val Ser Tyr Arg Ala Lys Thr Lys Leu Asn Pro Lys 
225                 230                 235                 240 


Asp Ile His Lys Gln Glu Glu Arg Asp Phe Glu Ile Pro Leu Ser Thr 
                245                 250                 255     


Ser Gly Ile Val Phe Leu Met Ser Leu Phe Leu Ser Lys Lys Glu Ile 
            260                 265                 270         


Glu Asp Phe Lys Ser Asn Ile Lys Gly Phe Lys Gly Lys Val Val Lys 
        275                 280                 285             


Asp Glu Asn His Asn Ser Leu Lys Tyr Met Ala Thr His Arg Val Tyr 
    290                 295                 300                 


Ser Ile Leu Ala Phe Lys Gly Leu Lys Tyr Arg Ile Lys Thr Asp Thr 
305                 310                 315                 320 


Phe Ser Lys Val Thr Leu Met Met Gln Met Ile Asp Glu Leu Ser Lys 
                325                 330                 335     


Val Pro Asp Cys Val Tyr Gln Asn Leu Ser Glu Thr Lys Gln Lys Asp 
            340                 345                 350         


Phe Ile Glu Asp Trp Asn Glu Tyr Leu Lys Asp Asn Glu Glu Asn Thr 
        355                 360                 365             


Glu Asn Leu Glu Asn Ser Arg Val Val His Pro Leu Ile Arg Lys Arg 
    370                 375                 380                 


Tyr Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe 
385                 390                 395                 400 


Ala Asn Phe Lys Thr Leu Lys Phe Gln Val Phe Met Gly Tyr Tyr Ile 
                405                 410                 415     


His Asp Gln Arg Thr Lys Thr Ile Gly Thr Thr Asn Ile Thr Thr Glu 
            420                 425                 430         


Arg Thr Val Lys Glu Lys Ile Asn Val Phe Gly Lys Leu Ser Lys Met 
        435                 440                 445             


Asp Asn Leu Lys Lys His Phe Phe Ser Gln Leu Ser Asp Glu Glu Asn 
    450                 455                 460                 


Thr Asp Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Phe Leu Thr Gln 
465                 470                 475                 480 


Ala Asp Asn Ser Pro Ala Asn Asn Ile Pro Ile Tyr Leu Glu Leu Lys 
                485                 490                 495     


Asn Gln Gln Ile Ile Lys Glu Lys Asp Asp Ile Lys Ala Glu Val Asn 
            500                 505                 510         


Asn Ser Gln Asn Arg Asn Pro Asn Lys Pro Ser Lys Arg Asp Leu Leu 
        515                 520                 525             


Asn Lys Ile Ser Asn Thr Asn Glu Asp Phe Tyr Gln Gly Asp Pro Thr 
    530                 535                 540                 


Ala Ile Leu Ser Leu Asn Glu Ile Pro Ala Leu Leu His Leu Phe Leu 
545                 550                 555                 560 


Val Gln Pro Asp Asn Lys Thr Gly Gln Gln Ile Glu Asn Ile Ile Arg 
                565                 570                 575     


Ile Lys Ile Glu Lys Gln Phe Asn Ser Ile Lys Asn Pro Ser Lys Asp 
            580                 585                 590         


Asp Lys Gly Val Pro Lys Ser Leu Phe Ala Asp Thr Asn Val Arg Val 
        595                 600                 605             


Asn Ala Ile Lys Leu Lys Lys Asp Leu Gly Glu Glu Leu Asp Met Leu 
    610                 615                 620                 


Asn Lys Lys Gln Ile Val Phe Lys Glu Asn Gln Lys Ala Ser Ser Asn 
625                 630                 635                 640 


Tyr Asp Glu Leu Leu Lys Lys His Gln Phe Thr Pro Lys Asn Lys Arg 
                645                 650                 655     


Pro Ala Leu Arg Lys Tyr Val Phe Tyr Asn Ser Glu Lys Gly Glu Glu 
            660                 665                 670         


Ala Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Lys Gly Phe 
        675                 680                 685             


Lys Thr Lys Trp Lys Gly Tyr Gln His Ser Glu Leu Gln Arg Lys Leu 
    690                 695                 700                 


Ala Phe Tyr Asp Arg His Thr Lys Gln Asp Ile Lys Glu Leu Leu Ser 
705                 710                 715                 720 


Gly Cys Glu Phe Asp His Phe Leu Leu Asp Ile Asn Ala Cys Phe Lys 
                725                 730                 735     


Glu Asp Asp Phe Glu Asp Phe Phe Ser Lys Tyr Leu Lys Asn Arg Ile 
            740                 745                 750         


Glu Thr Leu Asn Ile Ile Leu Lys Gln Leu His Asp Phe Lys Asn Glu 
        755                 760                 765             


Pro Thr Pro Leu Lys Gly Val Phe Lys Asn Cys Leu Lys Phe Leu Lys 
    770                 775                 780                 


Gln Lys Asn Tyr Val Thr Glu Asn Pro Glu Ile Ile Lys Lys Arg Ile 
785                 790                 795                 800 


Leu Ala Lys Pro Ala Phe Leu Pro Arg Gly Ile Phe Asp Glu Arg Pro 
                805                 810                 815     


Thr Met Lys Lys Gly Lys Asn Pro Leu Ile Asp Arg Asp Glu Phe Ala 
            820                 825                 830         


Lys Trp Phe Val Glu Tyr Leu Glu Asn Lys Asp Tyr Gln Lys Phe Tyr 
        835                 840                 845             


Asn Ser Glu Glu Tyr Arg Ile Arg Asp Ala Asp Phe Lys Lys Asn Ala 
    850                 855                 860                 


Val Ile Lys Lys Gln Lys Leu Lys Asp Phe Tyr Thr Leu Gln Met Val 
865                 870                 875                 880 


Asn Tyr Leu Leu Lys Glu Val Phe Gly Lys Asp Glu Met Asn Leu Gln 
                885                 890                 895     


Leu Ser Glu Leu Phe Gln Thr Arg Gln Glu Arg Leu Lys Leu Gln Gly 
            900                 905                 910         


Ile Ala Lys Lys Gln Met Asn Lys Glu Thr Gly Asp Ser Ser Glu Asn 
        915                 920                 925             


Thr Arg Asn Gln Thr Tyr Ile Trp Asn Lys Asp Val Pro Val Ser Phe 
    930                 935                 940                 


Phe Asn Gly Lys Val Thr Ile Asp Lys Val Lys Leu Lys Asn Ile Gly 
945                 950                 955                 960 


Lys Tyr Lys Arg Tyr Glu Arg Asp Glu Arg Val Lys Thr Phe Ile Gly 
                965                 970                 975     


Tyr Glu Val Asp Glu Lys Trp Met Met Tyr Leu Pro His Asn Trp Lys 
            980                 985                 990         


Asp Arg Tyr Ser Val Lys Pro Ile  Asn Val Ile Asp Leu  Gln Ile Gln 
        995                 1000                 1005             


Glu Tyr  Glu Glu Ile Arg Ser  His Glu Leu Leu Lys  Glu Ile Gln 
    1010                 1015                 1020             


Asn Leu  Glu Gln Tyr Ile Tyr  Asp His Thr Thr Asp  Lys Asn Thr 
    1025                 1030                 1035             


Leu Leu  Gln Asp Gly Asn Pro  Asn Phe Lys Met Tyr  Val Leu Asn 
    1040                 1045                 1050             


Gly Leu  Leu Thr Gly Ile Lys  Gln Val Asn Ile Ala  Asp Phe Ile 
    1055                 1060                 1065             


Val Leu  Lys Gln Asn Thr Asn  Phe Asp Lys Ile Asp  Phe Thr Gly 
    1070                 1075                 1080             


Ile Ala  Ser Cys Ser Glu Leu  Glu Lys Lys Thr Ile  Ile Leu Ile 
    1085                 1090                 1095             


Ala Ile  Arg Asn Lys Phe Ala  His Asn Gln Leu Pro  Asn Lys Thr 
    1100                 1105                 1110             


Ile Tyr  Asp Leu Ala Asn Glu  Phe Leu Lys Lys Glu  Lys Arg Glu 
    1115                 1120                 1125             


Thr Tyr  Ala Asn Tyr Tyr Leu  Lys Val Leu Lys Lys  Met Ile Ser 
    1130                 1135                 1140             


Asp Leu  Ala 
    1145     


<210>  1608
<211>  1057
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1608

Met Thr Ile Lys Glu Gln Ser His Phe Ala Ala Tyr Tyr Asn Met Ala 
1               5                   10                  15      


Arg His Asn Met Tyr Glu Thr Leu Cys Tyr Ile Ser Lys Ile Ser Gly 
            20                  25                  30          


Ile Gln Glu Gly Glu Asp Asn Lys Glu Ser Lys Ile Glu Asp Met Gln 
        35                  40                  45              


Leu Leu Arg Val Leu Thr Thr Lys Gly His Pro Glu Glu Lys Ile Arg 
    50                  55                  60                  


Ile Glu Lys Leu Ile Tyr Lys His Leu Pro Leu Phe Arg Pro Ala Val 
65                  70                  75                  80  


Glu Asp Leu Arg Lys Lys Ser Lys Glu Asn Val Lys Ser Pro Glu Leu 
                85                  90                  95      


Leu Ala Lys Val Ile Lys Asn Trp Ala Lys Val Ile Thr Tyr Tyr Arg 
            100                 105                 110         


Asp Lys Phe Thr His Tyr Val Phe Ile Asp Lys Arg His Glu Asn Lys 
        115                 120                 125             


Glu Phe Leu Asn Ala Glu Met Ser Val Ala Asn Asp Leu Asn Gln Ile 
    130                 135                 140                 


Phe Thr Ala Ser Ala Arg Val Ile Lys Glu Arg Phe Gly Leu Ser Thr 
145                 150                 155                 160 


Glu Leu Glu Phe Leu Thr Lys Gly Arg Tyr Arg Thr Gln Thr Ile Asp 
                165                 170                 175     


Gly Lys Arg Ser Thr Lys Leu Asn Pro Asn Phe Ile Tyr Ser Leu Gln 
            180                 185                 190         


Asp Lys Asn Glu Arg Leu Asn Lys Met Gly Leu Ile Phe Leu Ala Cys 
        195                 200                 205             


Gln Leu Ile Glu Lys Lys Tyr Ala Ser Met Leu Phe Asp Gln Gln Gly 
    210                 215                 220                 


Tyr Met Gly Arg Asp Ile Tyr Phe Asp Phe Thr Pro Ala Gln Cys Lys 
225                 230                 235                 240 


Tyr Ile Arg Glu Val Phe Ser Ala His Arg Ile Val Leu Pro Arg Gly 
                245                 250                 255     


Arg Met Asp Val Glu Arg Asn Glu Ile Thr Ile Ala Met Asp Met Phe 
            260                 265                 270         


Asn Glu Leu Gly Lys Cys Pro Lys Glu Leu Phe Glu Ile Ile Ser Lys 
        275                 280                 285             


Glu Glu Gln Lys Arg Phe Arg Thr Lys Ser Glu Thr Thr Gly Glu Glu 
    290                 295                 300                 


Val Leu Leu Met Arg His Ser Asp Arg Phe Ala Thr Leu Ala Leu Gln 
305                 310                 315                 320 


Tyr Ile Asp Asn Arg Lys Val Phe Glu Lys Ile Arg Phe Gln Leu Ser 
                325                 330                 335     


Leu Gly Lys Tyr Arg Tyr Lys Phe Tyr Asp Lys Thr Cys Val Asp Gly 
            340                 345                 350         


Asp Thr His Val Arg Ile Leu Gln Lys Glu Leu Asn Gly Phe Gly Arg 
        355                 360                 365             


Ile Asn Glu Ile Glu Leu Leu Lys Glu Glu Lys Trp Gly Gly Leu Ile 
    370                 375                 380                 


Arg Lys Phe Glu Asp Ala Lys Ile Asp Thr Ala Glu Thr Lys Pro Tyr 
385                 390                 395                 400 


Ile Thr Asp Gln Tyr Pro Gln Tyr Leu Phe Asn Gly Asn Arg Ile Gly 
                405                 410                 415     


Ile Tyr Phe Asn Ser Ala His Gly Lys Ala Met Arg Asn Gly Ala Tyr 
            420                 425                 430         


Ile Pro Asp Ile Glu Ser Gly Ala His Cys Ile Gln Pro Ile Cys Trp 
        435                 440                 445             


Ile Ser Asn Tyr Glu Leu Pro Ala Leu Ile Phe His His Ile Leu Thr 
    450                 455                 460                 


Lys Asp Glu Lys Lys Ser Leu Thr Glu Lys Ile Ile Ile Asp Cys Val 
465                 470                 475                 480 


Glu Arg Tyr Lys Lys Leu Phe Asn Asp Ile Ala Glu Gly Lys Val Ala 
                485                 490                 495     


Arg Thr Gly Asn Ala Thr Ser Asp Phe Glu Met Ile Ser Lys Glu Tyr 
            500                 505                 510         


Gly Ile Glu Lys Ser Asp Ile Pro Arg Glu Leu Gln Asp Tyr Phe Asn 
        515                 520                 525             


Gly Thr Glu Arg Asp Gly Ile Glu Gln Tyr Ala Lys Ala Gln Ile Arg 
    530                 535                 540                 


Glu Met Ile Glu Glu Asn Arg Ile Arg Leu Glu Gln Phe Asn Ser Lys 
545                 550                 555                 560 


Leu Lys Lys Ile Glu Asp Gly Glu Val Lys Tyr Gly Lys Arg Asp Tyr 
                565                 570                 575     


Thr Glu Ile Arg Thr Gly Glu Leu Ala Gln Tyr Leu Ala Lys Asp Ile 
            580                 585                 590         


Val Met Phe Met Pro Lys Ala Lys Tyr Lys Pro Thr Ser Lys Asn Tyr 
        595                 600                 605             


Asn Val Met Gln Ala Leu Leu Ala Thr Phe Asn Gly Ser Glu Ser Gly 
    610                 615                 620                 


Ser Thr Leu Asp Glu Val Asp Asp Met Phe Asp Asn Ile Lys Ala Cys 
625                 630                 635                 640 


Tyr Trp Lys Asn Glu Ser Asp Asn His Pro Phe Leu Glu Tyr Val Leu 
                645                 650                 655     


Gly Glu Glu Pro Lys Asp Ile Ile Ala Phe Tyr Lys Ile Tyr Leu Glu 
            660                 665                 670         


Leu Arg Gly Glu Tyr Leu Asp Lys Cys Ile Lys Lys Met Asp Leu Ala 
        675                 680                 685             


Thr Ile Pro Phe Ile His Thr Glu Arg Lys Arg Trp Glu Lys Arg Asp 
    690                 695                 700                 


Glu Lys Phe Phe Lys Glu Leu Ala Gln Arg Tyr Ala Thr Gln Pro Ile 
705                 710                 715                 720 


Glu Leu Pro Arg Gly Leu Tyr Asp Arg Ala Ile Lys Glu Tyr Leu Lys 
                725                 730                 735     


Ser Lys Ser Ile Leu Glu Asp Val Ile Ala Gln Glu Gln Cys Asn Val 
            740                 745                 750         


Thr Tyr Leu Ile Ala Arg Tyr Met Gln Asp Val Leu Lys Asp Asp Ser 
        755                 760                 765             


Gln Gln Phe Tyr Ser Leu Pro Arg His Tyr Ser Cys Leu Ser Glu Lys 
    770                 775                 780                 


Asp Lys Tyr Leu Ser Leu Thr Glu Arg Glu Ala Ile Ala Lys Ser Asp 
785                 790                 795                 800 


Ala Leu Asn Ser Phe Lys Lys Arg Glu Arg Glu Lys Glu Asn Glu Asn 
                805                 810                 815     


Arg Arg Gly Asn Arg Arg Tyr Asn Lys Gly Glu Asn Lys Asn Thr Ile 
            820                 825                 830         


Lys Asp Arg Asp Thr Glu Glu Lys Phe Asn Ser Leu Tyr Arg Lys Met 
        835                 840                 845             


Asp Asn Asn Glu Arg Ile Leu Arg Arg Tyr Lys Val Gln Asp Met Leu 
    850                 855                 860                 


Leu Tyr Leu Leu Ala Cys Asp Ile Ile Lys Gly Ile Met Arg Glu Asp 
865                 870                 875                 880 


Phe Gly Tyr Lys Leu Ser Met Ile Thr Asp Gly Lys Asn Ser Asn Phe 
                885                 890                 895     


Phe Asp Tyr Lys Met Pro Glu Phe Lys Thr Thr Ile Thr Leu Lys Glu 
            900                 905                 910         


Gly Lys Lys Phe Thr Ile Lys Gln Gln Tyr Leu Lys Ile Lys Asn Tyr 
        915                 920                 925             


Gly Asp Phe Leu Lys Phe Ile Phe Asp Leu Arg Ile Asp Ser Leu Leu 
    930                 935                 940                 


Ser Asn Gly Thr Lys Val Glu Ile Asp Arg Asn Ile Leu Glu Asp Glu 
945                 950                 955                 960 


Leu Ser Asn Tyr Asp Gly Ser Arg Pro Lys Val Phe Glu Thr Leu Leu 
                965                 970                 975     


Met Ile Glu Lys Ile Val Val Glu Lys His Lys Glu Leu Lys Asp Leu 
            980                 985                 990         


Glu His Ile Thr Phe Gly Asp Val  Leu Asn Val Ile Lys  Met Glu Glu 
        995                 1000                 1005             


Gly Glu  Lys Lys Ile Leu Arg  Leu Ile Arg Asn Ala  Phe Ser His 
    1010                 1015                 1020             


Asn Tyr  Tyr Pro Thr Ile Lys  Asp Val Asn Tyr Asp  Asn Met Pro 
    1025                 1030                 1035             


Glu Val  Ala Glu Ser Leu Lys  Asp Ile Leu Glu Lys  Glu Ser Lys 
    1040                 1045                 1050             


Lys Leu  Thr Asn 
    1055         


<210>  1609
<211>  1062
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1609

Met Asn Phe Glu Glu Asn Gly Asn Lys Tyr Leu Phe Gly Ala Phe Leu 
1               5                   10                  15      


Asn Thr Ala Tyr Asp Asn Tyr Asn Glu Val Ile Ser His Ile Tyr Asp 
            20                  25                  30          


Val Ile Arg Arg Ile Thr Asn Asn Asn Pro Thr Glu Gln Lys Ser Ser 
        35                  40                  45              


Ser Gln Ala Leu Ala Ser Glu Glu Pro Ile Ser Ser Glu Glu Lys Glu 
    50                  55                  60                  


Lys Met Phe Phe Val Cys Thr Ile Leu Ile Ala Gly Asn Ala Thr Ser 
65                  70                  75                  80  


Arg Lys Ile Glu Ser Ile Leu Lys Arg Ala Phe Pro Phe Trp Asp Asp 
                85                  90                  95      


Phe Ile Glu Ile His Ala Ser Leu Ser Ala Gln Leu Asp Lys Thr Glu 
            100                 105                 110         


Ser Ile Phe Gln Leu Gln Lys Asn Cys Val Glu Glu Leu Phe Thr Ala 
        115                 120                 125             


Leu Glu Ser Trp Arg Asn Tyr Thr Thr His Tyr Ile His Pro Glu Ala 
    130                 135                 140                 


Ile Ala Ser Pro Thr Ile Asn Leu Leu Leu Lys Ser Cys Phe Asn Gln 
145                 150                 155                 160 


Gly Ile Lys Glu Ile Lys Lys Arg Phe Asn Thr Lys Asp Glu Gln Leu 
                165                 170                 175     


Thr His Leu Tyr Glu Pro Glu Leu Phe His Asn Lys Glu Thr Asn Lys 
            180                 185                 190         


Asp Glu Ile Lys Cys Tyr His Pro Ala Asn Tyr Tyr Arg Phe Ala Asn 
        195                 200                 205             


Glu Asn Gly Leu Leu Thr Glu Lys Gly Leu Ala Phe Phe Thr Cys Leu 
    210                 215                 220                 


Phe Leu Tyr Lys Arg Glu Ser Tyr Leu Leu Leu Asn Gln Leu Lys Gly 
225                 230                 235                 240 


Phe Lys Arg Ala Asp Glu Glu Arg Tyr Arg Met Thr Leu Glu Ala Phe 
                245                 250                 255     


Thr Val Met Arg Phe Arg Ala Pro Lys Gln Leu Leu Lys Leu Gln Gln 
            260                 265                 270         


Gln Gln Leu Asp Lys Val Ser Leu Gly Ile Ser Met Ile Asn Glu Leu 
        275                 280                 285             


Ala Lys Cys Pro Lys Glu Leu Tyr Asp Cys Leu Glu Asn Glu Lys Arg 
    290                 295                 300                 


Arg Gln Phe Glu Val Tyr Pro Asp Thr Glu Thr Thr Leu Tyr Glu Gln 
305                 310                 315                 320 


Glu Ala Ile Gly Glu Leu Ile Arg Tyr Lys Asp Arg Tyr Glu Asn Leu 
                325                 330                 335     


Met Leu Lys Ala Leu Glu His Ser Ser Glu Cys Lys Tyr Met Gly Phe 
            340                 345                 350         


Tyr Leu Ser Leu Gly Lys Cys Tyr Met Lys Cys Tyr Glu Lys His Tyr 
        355                 360                 365             


Ile Asp Gly Thr Thr Asp Asn Arg Tyr Ile Val His Ser Leu Tyr Gly 
    370                 375                 380                 


Phe Gly Arg Leu Gln Asn Ala Ser Thr Asp His Lys Asn His Leu Ser 
385                 390                 395                 400 


Ser Phe Gly Glu Glu Leu Gln Thr His Ser Gln Leu Pro Val Cys His 
                405                 410                 415     


Phe Ala Thr Glu Asp Asp Ala Ala Asp Ser Pro Thr Ser Val Pro Tyr 
            420                 425                 430         


Ile Ser Glu Ser Tyr Pro Ser Tyr Val Leu Asn Asn Asn Asn Ile Gly 
        435                 440                 445             


Ile Lys Trp Leu Asn Ser Ser Glu Lys Thr Glu Tyr Pro Asn Phe Asn 
    450                 455                 460                 


Leu Asn Glu Gly Lys Val Ser Cys Pro Ala Pro Asp Tyr Trp Leu Ser 
465                 470                 475                 480 


Lys Tyr Glu Leu Pro Ala Met Ala Phe Tyr Ala Tyr Leu Lys Glu Lys 
                485                 490                 495     


His Lys Asn Lys Leu Gln Glu Tyr Pro Ser Ile Lys Glu Leu Ile Asp 
            500                 505                 510         


Gln Ser His Pro Glu Ala Thr Lys Thr Ser Ser Ser Thr Ile Lys Asp 
        515                 520                 525             


Arg Leu Glu Glu Arg Leu Lys Arg Tyr Lys Val Asp Ala Thr Lys Lys 
    530                 535                 540                 


Leu Lys Arg Leu Ala Glu Lys Pro Asp Gly Val Gln Ser Gly Arg Leu 
545                 550                 555                 560 


Ala Asp Glu Leu Ala Arg Asp Ile Leu Trp Leu Gln Pro Ser Ser Pro 
                565                 570                 575     


Lys Glu Gly Gly Lys Asp Lys Leu Thr Gly Ala Asn Phe Gln Ala Leu 
            580                 585                 590         


Gln Tyr Ala Leu Ala Arg Tyr Asp Phe Met Arg Thr Glu Leu Pro Arg 
        595                 600                 605             


Ile Leu Thr Ala Ala Arg Leu Thr Gly Ser Asn Asn Ala His Pro Phe 
    610                 615                 620                 


Leu Asp Lys Ile Asn Pro Gln Asp Tyr Ser Arg Leu Thr Ala Tyr Tyr 
625                 630                 635                 640 


Ala Gly Tyr Leu Thr Gln Lys Ile Val Tyr Ile Asp Lys Gln Leu Glu 
                645                 650                 655     


Lys Leu Ala Arg Gly Lys Val Asn Ile Gln Phe His Pro Thr Arg Lys 
            660                 665                 670         


Leu Ile Arg Gln Ser Gln Thr Asp Ser Val Glu His Glu Lys Glu Thr 
        675                 680                 685             


Val Phe Leu Pro Arg Asn Ile Phe Thr Glu Lys Ile Glu Gln Ala Leu 
    690                 695                 700                 


Cys Gln Ile Gln Gly Asn Phe Lys Leu Asn Ile Glu Lys Ala Arg Ile 
705                 710                 715                 720 


Ser Gly Lys Lys Leu Asn Ala Ser Lys Leu Ile Leu Ile Tyr Leu Glu 
                725                 730                 735     


Leu Tyr Leu Lys Asp Glu Val Pro Glu Phe Tyr Asn Ala Lys Arg Lys 
            740                 745                 750         


Tyr Pro Cys Leu Cys Tyr Pro Leu Thr Pro Ser Glu Lys Tyr Thr Leu 
        755                 760                 765             


Lys Glu Tyr Gln Asp Thr Glu Glu Arg Ser Lys Arg Ile Asp Arg Leu 
    770                 775                 780                 


Lys Cys Phe Tyr Asn Phe Lys Glu Val Ala Glu Lys Val Tyr Leu His 
785                 790                 795                 800 


Lys Glu Leu Ser Glu Asp Glu Asn Lys Arg Tyr Arg Lys Tyr Ile Glu 
                805                 810                 815     


Val Gln Lys Val Ile Asp Asn Glu Lys Ile Ile Arg Leu Arg Lys Val 
            820                 825                 830         


Gln Asp Ile Thr Leu Tyr Leu Trp Thr Arg Leu Phe Ile Glu Glu Asn 
        835                 840                 845             


Pro Glu Gln Ile Phe Phe Ser Lys Asn Glu Lys Pro Glu Asn Ser Leu 
    850                 855                 860                 


Phe Lys Leu Arg Glu Met Asn Asn Ala Ile Leu Asp Asn Thr Thr Ser 
865                 870                 875                 880 


Arg Lys Ile Asn Ile Asn Thr Pro Asn Gly Asn Val Ser Ile Glu Asp 
                885                 890                 895     


Glu Phe Lys Ile Lys Asp Tyr Gly Arg Val Thr Ala Leu Thr Thr Glu 
            900                 905                 910         


Lys Leu Pro Gln Ser Leu Ile Lys Phe Ile Ala Ile Leu Asn Lys Pro 
        915                 920                 925             


Leu Asn Lys Lys Asp Arg Pro Leu Leu Ser Tyr Asp Tyr Ile Tyr His 
    930                 935                 940                 


Glu Thr Asn Ala Phe Tyr Arg Tyr Arg Pro Glu Ile Ile Lys Met Ala 
945                 950                 955                 960 


Gln Asp Ile Glu Asn Lys Ile Ile Asn Asp Leu Lys Ile Asn Val Lys 
                965                 970                 975     


Pro Gln Ala Glu Ser Tyr Tyr Asn Phe Arg Arg Thr Ile Gln Lys Leu 
            980                 985                 990         


Glu Asn Lys Ser Arg Asp Ile Asn  Ile Glu Leu Leu Ile  Lys Ile Arg 
        995                 1000                 1005             


Asn Ala  Phe Cys His Asn Glu  Tyr Lys Glu Leu Asp  Asn Asp Gln 
    1010                 1015                 1020             


Tyr Lys  Tyr Leu Asn Ser Leu  Phe Lys Leu Ser Ser  Asp Ile Lys 
    1025                 1030                 1035             


Gln Thr  Asp Thr Leu Ala Tyr  Leu Leu Tyr Ile Leu  Phe Glu Thr 
    1040                 1045                 1050             


Glu Tyr  Gln Lys Val Met Ile  Leu Lys 
    1055                 1060         


<210>  1610
<211>  1171
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1610

Met Asn Leu Leu Glu Lys Thr Asn Ala Ala Glu Ser Cys Phe Asn His 
1               5                   10                  15      


Thr Ile Asn Asp Gln Lys Tyr Tyr Phe Ala Gly Tyr Leu Asn Leu Ala 
            20                  25                  30          


Gln Asn Asn Ile Lys Thr Leu Glu Lys Ala Tyr Gly Glu His Phe Leu 
        35                  40                  45              


Cys Ser Gly Asn Asn Pro Ile Ile Asn Asp Leu Thr Asn Thr Asn Ser 
    50                  55                  60                  


Leu Ile Asp Trp Asp Phe Lys Met Lys Phe Leu Ser Gln Tyr Leu Pro 
65                  70                  75                  80  


Ala Ile Ser Tyr Leu Asn Leu Glu Thr Asp Leu Asn Glu Ser Phe Glu 
                85                  90                  95      


Lys Arg Lys Lys Glu Phe Thr Lys Asn Leu Ser Phe Leu Phe Asn Ala 
            100                 105                 110         


Ile Asp Leu Leu Arg Asn Phe Tyr Ser His Tyr Tyr His Ala Pro Leu 
        115                 120                 125             


Ile Asp Glu Leu Asn Ser Glu Arg Leu Ile Phe Leu Asp Lys Ile Phe 
    130                 135                 140                 


Val Ala Val Cys Ile Asn Val Lys Lys Lys Arg Met Lys Asp Asp Lys 
145                 150                 155                 160 


Thr Lys Gln Leu Leu Lys Ala Thr Leu Ile Asp Glu Leu Asp Leu Leu 
                165                 170                 175     


Leu Lys Ala Lys Lys Glu Glu Leu Leu Lys Lys Lys Lys Glu Gly Lys 
            180                 185                 190         


Lys Val Ser Thr Asp Ala Ile Ser Met Lys Asn Ser Val Leu Asn Asp 
        195                 200                 205             


Ala Phe Asn His Leu Ile Gln Leu Glu Lys Asn Ser Lys Lys Glu Ile 
    210                 215                 220                 


Pro Gly Arg Tyr Tyr Thr Ser Leu Leu Asn Asp Asn Asn Lys Tyr Thr 
225                 230                 235                 240 


Glu Asn Gly Ile Asn Ile Ser Ile Ser Gly Leu Leu Phe Leu Leu Ser 
                245                 250                 255     


Met Phe Leu Thr Lys Lys Gln Asn Glu Asp Val Arg Ser Arg Ile Phe 
            260                 265                 270         


Gly Phe Lys Gly Thr Ile Glu Ser Asp Lys Gly Ile Ser Lys Ser Asn 
        275                 280                 285             


Asn Ser Phe Arg Asn Met Ala Thr Asn Trp Val Phe Ser Tyr Leu Ser 
    290                 295                 300                 


Phe Lys Gly Met Lys Lys Gln Leu Gly Ser Thr Phe Asn Lys Glu Ser 
305                 310                 315                 320 


Leu Leu Val Gln Ile Val Asp Glu Leu Ser Lys Val Pro His Glu Val 
                325                 330                 335     


Tyr Gln Thr Leu Ser Pro Ser Arg Gln Glu Met Phe Leu Glu Asp Met 
            340                 345                 350         


Asn Glu Tyr Leu Lys Asp Gly Asn Lys Lys His Cys Leu Glu Asp Ser 
        355                 360                 365             


Ile Val Val His Pro Val Ile Lys Lys Arg Tyr Glu Asp Lys Phe Asn 
    370                 375                 380                 


Tyr Phe Ala Ile Arg Tyr Leu Asp Glu Phe Val Asp Phe Pro Ser Leu 
385                 390                 395                 400 


Arg Phe Gln Val Asn Val Gly Asn Tyr Val His Asp Arg Arg Lys Lys 
                405                 410                 415     


Thr Ile Asp Gly Thr Asn Thr Glu Thr Asp Arg Met Val Lys Glu Glu 
            420                 425                 430         


Ile Arg Ala Phe Gly Lys Leu Ser Phe Ile Ser Lys Leu Lys Ala Asp 
        435                 440                 445             


Tyr Phe Ala Lys Asp Leu Pro Ser Asp Ile Ser Trp Glu Met Tyr Pro 
    450                 455                 460                 


Asn Pro Ser Tyr Asn Phe Ser Ala Asn Asn Ile Pro Val Tyr Ile Asp 
465                 470                 475                 480 


Leu Phe Lys Ser Ser Val Ala Gly Ala Ala Asp Val Gly Lys Asp His 
                485                 490                 495     


Lys Gly Tyr Gln Ala Lys Leu Asp Leu Asp Glu Asp Gly Lys Lys Arg 
            500                 505                 510         


Asn Arg Asn Glu Gly Lys Pro Asp Lys Lys Glu Ile Ala Glu Ile Leu 
        515                 520                 525             


Phe Gly Lys Lys Asn Lys Gln Ile Leu Phe Glu Lys Pro Thr Val Leu 
    530                 535                 540                 


Leu Ser Leu Asn Glu Leu Pro Ala Met Leu Tyr Glu Val Leu Ile Glu 
545                 550                 555                 560 


Asn Gly Asp Lys Gln Asp Ile Gly Lys Arg Ile Glu Asp Lys Ile Val 
                565                 570                 575     


Glu Lys Ile Ile Ala His Tyr Asn Leu Leu Asp Gln Tyr Asp Gly Thr 
            580                 585                 590         


Thr Glu Leu Pro Gly Ser Val Ile Pro Arg Lys Leu Arg Met Gly Gly 
        595                 600                 605             


Asn Glu Lys Ser Ile Asn Ile Asp Lys Leu Leu Arg Ala Val Lys Arg 
    610                 615                 620                 


Glu Leu Glu Ile Thr Gln Glu Lys Leu Asp Leu Ile Lys Thr Asn Gln 
625                 630                 635                 640 


Lys Lys Phe Lys Ser Lys Glu Lys Asp Glu Lys Gly Asn Ser Arg Gln 
                645                 650                 655     


His Val Phe Tyr Thr Asn Glu Leu Gly Gln Glu Ala Thr Trp Ile Ala 
            660                 665                 670         


Asn Asp Met Lys Arg Phe Met Pro Lys Glu Val Lys Glu Lys Trp Arg 
        675                 680                 685             


Gly Tyr His His Ser Asn Leu Gln Lys Leu Leu Ala Leu Tyr Asp Gln 
    690                 695                 700                 


Thr Arg Asn Glu Ala Val Lys Cys Ile Thr Cys Phe Trp Asn Phe Asp 
705                 710                 715                 720 


Gln Gln Thr Ser Trp Gly Lys Gly Ile Lys Glu Ala Phe Tyr Lys Ser 
                725                 730                 735     


Thr Phe Glu Glu Phe Tyr Lys Ala Tyr Leu Glu His Arg Met Asp Val 
            740                 745                 750         


Tyr Lys Thr Leu Glu Asn Asn Leu Ile Ala Gly Lys Gly Tyr Ser Lys 
        755                 760                 765             


Leu Phe Asn Lys Glu Lys Lys Lys Ala Phe Ile Leu Phe Asp Glu His 
    770                 775                 780                 


Leu Tyr Thr Ile Pro Asp Ile Asn Thr Gln Lys Glu Arg Leu Lys Ser 
785                 790                 795                 800 


Thr Leu Phe Ile Leu Pro Arg Gly Ile Phe Asp Ser Lys Pro Thr Phe 
                805                 810                 815     


Ile Lys Gly Ile Lys Tyr Glu Glu Asp Pro Ser Cys Phe Ala Asp Trp 
            820                 825                 830         


Tyr Gln Phe Ala Asn Ala Thr Gly Asn Gln Tyr Gln Arg Phe Tyr Asp 
        835                 840                 845             


Leu Pro Arg Ser Tyr Thr Ser Leu Phe Glu Glu Thr Lys Lys Asn Asn 
    850                 855                 860                 


Glu Gly Leu Ile Glu Asn Lys Lys Gly Leu Ser Ala Lys Glu Gln Leu 
865                 870                 875                 880 


Asp Phe Phe Lys Met Arg Gln Asp Leu Lys Ile Lys Lys Ile Lys Thr 
                885                 890                 895     


Gln Asp Leu Phe Leu Phe Met Ile Val Arg Asp Leu Tyr Lys Lys Val 
            900                 905                 910         


Phe Asp His Thr Leu Pro Leu Glu Ile Gly Leu Arg Asp Met Tyr Gln 
        915                 920                 925             


Thr Pro Ala Glu Arg Gln Ala Asn Tyr Asp Leu Ala Val Lys Gln Ser 
    930                 935                 940                 


Gln Arg Thr Glu Gly Asp Asn Ser Asp Asn Leu Tyr Asn Tyr Asn Phe 
945                 950                 955                 960 


Leu Trp Asn Leu Thr Ile Pro Phe Glu Tyr Asp Lys Ile Lys Glu Pro 
                965                 970                 975     


Gln Val Lys Leu Lys Asp Val Gly Lys Phe Tyr Lys Phe Ala Ala Asp 
            980                 985                 990         


Glu Lys Val Gln Thr Ile Leu Ser  Tyr Ser Asp Arg Glu  Trp Ser Lys 
        995                 1000                 1005             


Leu Asp  Leu Glu Lys Glu Leu  Glu Leu Met Pro Thr  Ser Tyr Glu 
    1010                 1015                 1020             


Val Ile  Arg Arg Glu Gln Leu  Leu Arg Asp Ile Gln  Gln Phe Glu 
    1025                 1030                 1035             


Lys Arg  Ile Leu Glu Asn Tyr  Pro Ser Asp Gly Asn  Ala His Pro 
    1040                 1045                 1050             


Ala Asp  Leu Glu Lys Glu Asp  Lys Asp Lys Lys Cys  Phe Pro Asn 
    1055                 1060                 1065             


Phe Asn  Leu Tyr Leu Leu Lys  Gly Ile Ile Ile Lys  Asn Asn Leu 
    1070                 1075                 1080             


Ala Ser  Glu Glu Glu Arg Gln  Trp Phe Glu Gln Val  His Leu Asp 
    1085                 1090                 1095             


Lys Thr  Pro Phe Tyr Pro Glu  Val Glu Thr Lys Ser  Ser Ile Ile 
    1100                 1105                 1110             


Gln Ser  Ala Tyr Leu Leu Leu  Leu Ile Arg Asn Lys  Met Leu His 
    1115                 1120                 1125             


Asn Gln  Leu Pro Ser Lys Gln  Asn Phe Glu Phe Met  Thr Thr Leu 
    1130                 1135                 1140             


Tyr Pro  Phe Glu Gly Tyr Glu  Ser Tyr Ser Thr Tyr  Leu Leu Phe 
    1145                 1150                 1155             


Val Thr  Lys Lys Thr Ile Glu  Cys Leu Ser Ser Ala  Met 
    1160                 1165                 1170     


<210>  1611
<211>  1062
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1611

Met Tyr Lys Gly Lys Phe Asn Gln Arg Asn Ser Gly Asn Asn Ser Lys 
1               5                   10                  15      


Arg Met Arg Lys Pro Gln Phe Leu Pro Ser Asn Pro Val Ile Ala Leu 
            20                  25                  30          


Gln Lys Leu Cys Asn Thr Pro Gln His Glu Thr Lys Val Glu Glu Glu 
        35                  40                  45              


Lys Lys Tyr Phe Leu Leu Tyr Leu Asn Tyr Ala Val Asn Asn Leu Gln 
    50                  55                  60                  


Arg Leu Val Ala Asp Asp Arg Ile Glu Thr Arg Met Lys Asn Glu Lys 
65                  70                  75                  80  


Ser Gln Pro Asp Lys Ser Glu Val Leu Pro Glu Asn Leu Phe Glu Val 
                85                  90                  95      


Asp Asp Lys Val Val Asp Gly Lys Lys Lys Tyr Gly Val Arg Ser Arg 
            100                 105                 110         


Leu Glu Lys Ala Asp Asp Ala Thr Ile Leu Lys Leu Ala Asn Phe Leu 
        115                 120                 125             


Trp Leu Phe Asn Val Asp Glu Pro Glu Arg Asp Phe Lys Asp Phe Arg 
    130                 135                 140                 


Lys Leu Thr Ile Met Leu Val Thr Arg Ile Tyr Ala Leu Arg Asn Leu 
145                 150                 155                 160 


Phe Ala His Thr Asp Lys Gly Asn Ser Asp Pro Leu Leu Ala Asp His 
                165                 170                 175     


Glu Phe Tyr Val Leu Met Glu Gly Ile Phe Lys Ser Ala Ala Asn Asn 
            180                 185                 190         


Asn Ala Met Ser Glu Gly Val Arg Met Asp Lys Leu Tyr Lys Leu Lys 
        195                 200                 205             


Leu Leu Thr Lys His Thr Asp Leu Glu Lys Asp Asp Pro Asn Tyr Asn 
    210                 215                 220                 


Ala Ala Gln Ala Tyr Glu Phe Thr Arg Lys Gly Ile Ile Phe Leu Thr 
225                 230                 235                 240 


Cys Leu Ala Leu Tyr Lys Asp Glu Ala His Glu Phe Cys Gln Leu Phe 
                245                 250                 255     


Val Asp Met Arg Leu Pro Ala Tyr Cys Pro Lys Trp Arg Glu Lys Cys 
            260                 265                 270         


Ser Glu Met Glu Asp Cys Asn Val Ile Glu Lys Thr Cys Asn Ala Ala 
        275                 280                 285             


Lys Ala Lys Ala Met Ile Thr Met Phe Thr Tyr Phe Ser Cys Arg Arg 
    290                 295                 300                 


Gly Arg Thr Val Leu Asn Ala Gln Thr Gln Asp Tyr Met Cys Phe Ser 
305                 310                 315                 320 


Asp Ile Val Thr Tyr Leu Asn Lys Val Pro Ala Ala Ala Tyr Asp Tyr 
                325                 330                 335     


Ser Glu Arg Met Ala Ala Glu Gly Lys Thr Asp Pro Leu Ala Ser Glu 
            340                 345                 350         


Arg Thr Lys Leu Ala Ala Leu Ala Ala Thr Ser Thr Glu Ser Glu Glu 
        355                 360                 365             


Asn Lys His Phe Lys Tyr Asp Leu Gln Arg Arg Phe Gln Glu Arg Phe 
    370                 375                 380                 


Leu Ser Phe Ala Ala Gly Tyr Cys Glu Asp Phe Gly Leu Ile Pro Ala 
385                 390                 395                 400 


Leu His Phe Lys Arg Leu Asp Val Ser Gln Lys Leu Gly Arg Lys Arg 
                405                 410                 415     


Tyr Cys Phe Gly Ser Asp Arg Asn Asp Glu Leu Gln Val Arg Met Asp 
            420                 425                 430         


Arg His Tyr Ala Ile Ala Arg Asp Ser Ile Gly Phe Glu Tyr Leu Pro 
        435                 440                 445             


Lys Thr His Tyr Gly Asp Ile Lys Ile Gly Ser Leu Arg Gly Thr Val 
    450                 455                 460                 


Ser Glu Asn Glu Leu Lys Gln Leu Leu Tyr Leu Cys Gly Lys Ile Asp 
465                 470                 475                 480 


Val Asn Lys Gly Val Asp Ala Tyr Phe Ala Ala Tyr His Arg Val Leu 
                485                 490                 495     


Glu Lys Met Leu Asn His Pro Asp Gly Glu Asp Phe Arg Phe Glu Asp 
            500                 505                 510         


Phe Val Asp Asp Phe Cys Thr Ile Ala Gly Val Ser Gln Glu Lys Leu 
        515                 520                 525             


Leu Glu Asp Arg Arg Lys Ile Leu Glu Pro Tyr Phe Pro Pro Asn Leu 
    530                 535                 540                 


Arg Arg Phe Phe Phe Gly Asp Asp Met Gln Leu Thr Gln Glu Glu Leu 
545                 550                 555                 560 


Arg Glu Gln Leu Cys Arg Arg Leu Glu Val Met Ala Phe Gln Ala Glu 
                565                 570                 575     


Asp Phe Leu Thr Arg Leu Arg Ser Phe Asn Gln Trp Arg Glu Glu Asp 
            580                 585                 590         


Lys Asn Thr Arg Ala Lys Asn Pro Pro Asp Cys Ser Val Lys Val Ile 
        595                 600                 605             


Asn Phe Ser Asn His Ser Gly Arg Ile Pro Asp Ser Glu Leu Ile Arg 
    610                 615                 620                 


Trp Val Phe Asn Tyr Ile Asn Leu Phe Leu Lys Pro Glu Asp Lys Phe 
625                 630                 635                 640 


Arg Gln Leu Pro Arg Gly Glu Gln His His Pro Gly Thr Arg Asp Cys 
                645                 650                 655     


Glu Tyr Gln Leu Leu His Ala Ala Ile Gly Lys Tyr Ser Leu Asp Gln 
            660                 665                 670         


Lys Gly Cys Pro Ala Leu Leu Arg Lys Leu Arg Pro Asp Cys Pro Leu 
        675                 680                 685             


Thr Gly Val Gly Asn Gly Glu Ile Lys Thr Val Asn Trp Asn Gly Thr 
    690                 695                 700                 


Phe Tyr Ala Lys Leu Cys Ser Ile Lys Asp Ala Gly Arg Lys Lys Leu 
705                 710                 715                 720 


Lys Asp Asn Pro Arg Tyr Asp Ala Asn Gly Lys Pro Val Arg Phe Thr 
                725                 730                 735     


Trp Ser Leu Phe Met Leu Ala Glu Ala Ala Ala Val Cys Tyr Lys Asp 
            740                 745                 750         


Phe Cys Gln Glu Glu Leu His Lys Trp Lys Thr Cys Asp Ala Tyr Ser 
        755                 760                 765             


Val Gly Ile Asp Glu Leu Arg Ala Ile Cys Arg Arg Phe Gly Val Arg 
    770                 775                 780                 


Pro Gly Met Pro Leu Asp Arg Glu Ser Leu Ile Lys Thr Ile Leu Lys 
785                 790                 795                 800 


Ile Asp Leu Glu Lys Trp Arg His Ala Phe Asp Tyr Ser Ser Gly Lys 
                805                 810                 815     


Pro Tyr Gly Asp Arg Val Leu Ser Ser Val Glu His Ile Val Pro Gln 
            820                 825                 830         


Val Ser Leu Pro Ala Gly Phe Gly Gln Arg Leu Ile Ala Gly Asp Cys 
        835                 840                 845             


Pro Lys Pro Phe Arg Gly Phe Phe Arg Glu Asp Gly Ile Phe Asp Phe 
    850                 855                 860                 


Asn Arg Ala Met Arg Ala Thr Leu Asn Phe Pro Val Ala Leu Arg Gly 
865                 870                 875                 880 


Tyr Tyr Asp Thr Lys Pro Leu Val Asp Gly Met Arg Ala Ile Ile Thr 
                885                 890                 895     


Ala Asp Gly Lys Gly Lys Thr Ala Lys Lys Ser Ala Leu Asp Lys Ala 
            900                 905                 910         


Ala Arg Ala Ile Ala Arg Ser His Cys Gln Asp Leu Leu Leu Arg Glu 
        915                 920                 925             


Ile Ala Phe Lys Tyr Arg Asp Arg Ala Phe Arg Asn Glu Gln Ala Leu 
    930                 935                 940                 


Ser Tyr Thr Val Lys His Asp Lys Gly Gly Ser Ile Tyr Glu Tyr Phe 
945                 950                 955                 960 


Ser Ser Glu Asp Thr Met Lys Ile Gly Lys Phe Thr Val Arg Phe Leu 
                965                 970                 975     


Pro Asn Val Val Thr Arg Pro Ala Phe Ser Leu Met Thr Asp Lys Ala 
            980                 985                 990         


Val Val Glu Thr Leu Ile Arg Val  Asn Lys Trp Glu Gly  Thr Glu Phe 
        995                 1000                 1005             


Asp Phe  Tyr Arg Leu Val Glu  Ala Leu Lys Val Leu  Gln Ala Ser 
    1010                 1015                 1020             


Asp Arg  Asn Lys Arg Leu Glu  Leu Leu Pro Tyr Leu  Ala Glu Phe 
    1025                 1030                 1035             


Asp Lys  Arg Val Lys Thr Asp  Asp Leu Val Tyr Glu  Gly Lys Thr 
    1040                 1045                 1050             


Ser Glu  Gly Asp Val Arg Leu  Ala Glu 
    1055                 1060         


<210>  1612
<211>  1147
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1612

Met Arg His Gln Gln Asn Ala Gln Tyr Gly Ala Cys Gln Trp Arg Asp 
1               5                   10                  15      


Arg Ala Ser Ala Lys Lys Arg Thr Tyr Leu Ser Gly Asp Tyr Lys Lys 
            20                  25                  30          


Asp Met Ala Thr Leu Arg Ile Phe Gly Asn Ile Arg Asn Pro Gln Thr 
        35                  40                  45              


Arg Lys Asp Glu Phe Lys Asp Glu Val Pro Gln Phe Ile Thr Tyr Leu 
    50                  55                  60                  


Thr Leu Ala Leu Gln Asn Val Ser Glu Ile Ile Gly Lys Arg Lys Asp 
65                  70                  75                  80  


Leu Ser Asn Leu Arg Asp Glu Ser Ser Val Lys Thr Ala Leu Glu Glu 
                85                  90                  95      


Ser Gly Arg Leu Phe Glu Val Ala Ser Phe Leu Trp Met Tyr Arg Val 
            100                 105                 110         


Glu Glu Pro Gly Arg Asp Tyr Asp Arg Ile Lys Lys Gly Glu Tyr Ala 
        115                 120                 125             


Asp Arg Ala Lys Glu Ile Val Val Ala Leu Trp Lys Leu Arg Asn Met 
    130                 135                 140                 


Phe Val His Pro Tyr Glu Arg Asn Ala Ala Arg Ala Leu Ile Val Ser 
145                 150                 155                 160 


Pro Glu Phe Tyr Arg Phe Ile Glu Gly Glu Leu Tyr Ser Glu Ala Arg 
                165                 170                 175     


Glu His Ala Leu Gly Pro Gly Arg Lys Ser Glu Lys Ile Phe Lys Leu 
            180                 185                 190         


Lys Leu Phe Asn Pro His Asp Asp Ala Arg Thr Thr Phe Glu Phe Thr 
        195                 200                 205             


Arg Lys Gly Leu Ile Phe Leu Thr Cys Leu Gly Leu Tyr Arg His Asp 
    210                 215                 220                 


Ala Ser Glu Phe Ile Gln Gln Phe Pro Asp Leu Gln Leu Pro Pro Arg 
225                 230                 235                 240 


Glu Trp Gln Val Glu Gln Gly Tyr Arg Ala Lys Pro Ser Glu Ser Glu 
                245                 250                 255     


Leu Val Glu Leu Arg Lys Lys Gly Gly Val Val Lys Ser Ile Leu Asp 
            260                 265                 270         


Ala Phe Thr Trp Tyr Ser Met Arg Ala Ser Arg Met Asp Ile Asp Val 
        275                 280                 285             


Ala Asn Ser Asp Tyr Leu Asn Phe Ala Asn Ile Leu Val Tyr Leu Asn 
    290                 295                 300                 


Lys Val Pro Ser Ala Ala Tyr Asn Tyr Leu Leu Leu Asp Asp Glu Ala 
305                 310                 315                 320 


Lys Arg Leu Thr Lys Arg Ala Ala Ala Ser Gln Glu Ser Glu Glu Asn 
                325                 330                 335     


Lys Arg Phe Lys Tyr Leu Leu Gln Glu Arg Lys Lys Asp Arg Phe Leu 
            340                 345                 350         


Thr Leu Ala Leu Ala Tyr Leu Glu Asp Phe His Lys Leu Asp Cys Ile 
        355                 360                 365             


Arg Phe Lys Arg Leu Asp Ile Thr Val Arg Pro Asp Arg Lys Arg Tyr 
    370                 375                 380                 


Met Phe Gly Pro Ile Pro Glu Gly Thr Val Asn Glu Arg Gly Glu Pro 
385                 390                 395                 400 


Leu Ser Asp Ala Asn Gly Met Asp Arg His Tyr Ala Ile Gln Asn Gly 
                405                 410                 415     


Ser Ala Gln Phe Glu Phe Val Pro Glu Gln His Tyr Gly Pro Ile Gln 
            420                 425                 430         


Ile Lys Arg Leu Arg Gly Ala Val Ser Glu Gly Glu Ile Met Arg Leu 
        435                 440                 445             


Leu Leu Val Met Phe Asp Asn Gly Ile Arg Arg Lys Asn Pro Asn Asp 
    450                 455                 460                 


Val Ile Lys Glu Tyr Leu Ile Ala Tyr His Arg Ile Leu Glu Arg Met 
465                 470                 475                 480 


Leu Asn Ala Gly Asp Thr Gly Ala Phe Thr Phe Asp Asp Pro Leu Phe 
                485                 490                 495     


Arg Ala Asp Phe Lys Thr Val Ser Gly Lys Gly Asp Asp Val Phe Thr 
            500                 505                 510         


Lys Gly Arg Phe Val Gly Glu Met Lys Pro Phe Phe Ser Glu Asn Val 
        515                 520                 525             


Thr Arg Tyr Phe Val Gly Asp Glu Leu Arg Pro Thr Pro Glu Ala Leu 
    530                 535                 540                 


Gln Lys Lys Leu Val Lys Arg Phe Glu Ala Met Gln Gly Arg Ala Glu 
545                 550                 555                 560 


Asp Phe Leu Leu Lys Met Asn Arg Leu Thr Asp Trp Arg Lys Leu Asp 
                565                 570                 575     


Leu Glu Ala Arg Lys Asp Lys Ala Phe Pro Val Cys Thr Ile Gly Glu 
            580                 585                 590         


Leu Lys Tyr Pro Pro Arg Thr Cys Lys Val Asn Asp Ala Gln Leu Val 
        595                 600                 605             


Lys Trp Val Leu Arg Tyr Ile Asn Leu Phe Leu Ala Lys Glu Glu Lys 
    610                 615                 620                 


Phe Arg Gln Leu Pro Arg Gly Leu Arg His Arg Gly Val Arg Asp Phe 
625                 630                 635                 640 


Glu Phe Gln Leu Leu His Thr Asp Ile Gly Arg Phe Gly Val Asn Pro 
                645                 650                 655     


Asp Ala Leu Trp Arg Thr Leu Glu Lys Arg Ser Ser Ile Asn Gly Glu 
            660                 665                 670         


Asp Gly Ala Leu Lys Met Leu Glu Asp Arg Glu Gln Glu Leu Phe Arg 
        675                 680                 685             


Ser Glu Gln Asn Arg Cys Arg Gly Lys Arg Asp Arg Asn Gly Lys Pro 
    690                 695                 700                 


Leu Arg Pro Gly His Thr Leu Thr Met Leu Ala Thr Ala Ala Ala Glu 
705                 710                 715                 720 


Leu Tyr Arg Glu Phe Ser Glu Ser Phe Arg Ser Glu Tyr Ser Val Pro 
                725                 730                 735     


Leu Ser Asp Glu Asp Lys Asp Leu Leu Pro Tyr Val Cys Pro Thr Tyr 
            740                 745                 750         


Gly Val Arg Ala Gly Leu Pro Leu Asp Gln Lys Ser Leu Val Lys Thr 
        755                 760                 765             


Val Leu Gly Ile Asp Leu Asp Thr Trp Ser Arg Ala Tyr Asp Tyr Ala 
    770                 775                 780                 


Thr Gly Arg Asn Phe Glu Asn Arg Arg Leu Ser Asn Ala His Asp Leu 
785                 790                 795                 800 


Ile Val Ser Gln Val Pro Met Pro Asn Ala Phe Ala Ile Arg Cys Val 
                805                 810                 815     


Lys Pro Gly Glu Asn Gly Glu Pro Phe Lys Phe Asn Pro Glu Phe Arg 
            820                 825                 830         


Thr Phe Met Pro Tyr Glu Arg Gly Lys Met Ser Leu Arg Gly Tyr Tyr 
        835                 840                 845             


Asp Ala Thr Pro Leu Ile Val Ala Val Lys Arg Phe Asp Glu Gln Ser 
    850                 855                 860                 


Ser Leu Gly Lys Gly Gly His Glu Arg Ala Asn Ala Glu Ile Arg Cys 
865                 870                 875                 880 


Ser Gly Thr Glu Gly Ile Glu Thr Arg Glu Trp Thr Asp Asp Gly Asp 
                885                 890                 895     


Ile Gly Ser Gly Lys Glu Pro Pro Arg Ser Arg Pro Ser Phe Ala Arg 
            900                 905                 910         


Gly Asp Val Asn Lys Ala Ile Gln Ala Ile Gln Leu Ala Glu Arg Gln 
        915                 920                 925             


Asp Lys Val Leu Leu Ala Cys Ala Lys Ala Tyr Trp Asp Arg Tyr Met 
    930                 935                 940                 


Gly Glu Glu Val Thr Ala Thr Gln Asn Glu Thr Gly Lys Lys Asp Gln 
945                 950                 955                 960 


Gln Lys Lys Asn Lys Ile Lys Asn Phe His Leu Ala Glu Ala Ala Asp 
                965                 970                 975     


Ile Gly Glu Phe Phe Ser Leu Pro Ile Asp Asp Thr Val Asn Gly Val 
            980                 985                 990         


Lys Ile Arg Met Met Pro Asn Asp  Phe Ala Arg Pro Ala  Tyr Gly Val 
        995                 1000                 1005             


Val Thr  Thr His Val Lys Glu  Leu Val Glu Gly Val  Lys Pro Leu 
    1010                 1015                 1020             


Pro Glu  Thr Asp Ser Val Tyr  Ser Phe Tyr Asp Leu  Trp Leu Glu 
    1025                 1030                 1035             


Leu Arg  Asn Leu Gln His Lys  Glu Asn Arg Val Arg  Leu Asp Phe 
    1040                 1045                 1050             


Leu Pro  Ala Ala Val Lys Phe  Asn Ala Cys Val Asn  Ile Pro Thr 
    1055                 1060                 1065             


Asn Leu  Glu Ser Leu Pro Asn  Asp Asp Pro Glu Lys  Thr Pro Arg 
    1070                 1075                 1080             


Ile Leu  Ser His Cys Asn Lys  Ala Leu Arg Leu Leu  Arg Leu Arg 
    1085                 1090                 1095             


Gly Asn  Val Glu Pro Leu Ser  Glu Glu Glu Tyr Leu  Leu Leu Ala 
    1100                 1105                 1110             


Lys Phe  Glu Pro Arg Leu Arg  His Pro Ala Arg Lys  Gly Leu Asp 
    1115                 1120                 1125             


Leu Val  His Phe Asp Thr Asp  Ala Val Arg Ala Ile  Tyr Lys Arg 
    1130                 1135                 1140             


Phe Gly  Phe Leu 
    1145         


<210>  1613
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1613

Met Lys Ala Asn Asn Gln Ile Val Lys Gly Ile Ser Tyr Asp His Leu 
1               5                   10                  15      


Lys Pro Asp Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asp Gly Val Ile Gln Glu Phe Thr Met Arg Leu Asn Leu 
        35                  40                  45              


Lys Tyr Asp Pro Glu Asn Lys Asn Gln Ser Leu Phe Ser Tyr Phe Asp 
    50                  55                  60                  


Ile Asn Ala Ser Phe Thr Asp Trp Glu Arg Gly Val Asn Ile Leu Lys 
65                  70                  75                  80  


Glu Tyr Trp Pro Val Met Glu Phe Ile Asp Arg Pro Ala Thr Asp Lys 
                85                  90                  95      


Gln Phe Glu Ser Glu Lys Pro Glu Asn Arg Glu Ala Ala Lys Arg Lys 
            100                 105                 110         


Tyr Phe Ile Ala Thr Leu Arg Ile Leu Leu Lys Ser Ile Lys Glu Leu 
        115                 120                 125             


Arg His Tyr Tyr Thr His Tyr Tyr His Pro Pro Val Gln Leu Ser Glu 
    130                 135                 140                 


Asp Leu Phe Arg Phe Leu Asp His Thr Leu Leu Tyr Thr Ala Phe Asp 
145                 150                 155                 160 


Val Lys Lys Thr Lys Met Lys Asp Asp Lys Thr Arg Gln Leu Leu Asn 
                165                 170                 175     


Gln Asn Leu Ser Leu Glu Leu Glu Lys Leu Lys Lys Leu Lys Val Glu 
            180                 185                 190         


Glu Leu Lys Lys Lys Lys Glu Lys Gly Ile Lys Val Asn Leu Gln Asp 
        195                 200                 205             


Glu Lys Gly Ile Leu Asn Ala Ile Tyr Asn Asp Ala Phe Ala His Ile 
    210                 215                 220                 


Ile Thr Lys Glu Lys Asp Ser Asp Lys Asp Glu Leu Glu Thr Arg Tyr 
225                 230                 235                 240 


Lys Ser Thr Leu Pro Gln Asp Glu Thr Ala Glu Ala Gly Ile Asn Ile 
                245                 250                 255     


Ser Ile Ser Gly Leu Ile Phe Leu Leu Ser Leu Phe Leu Ser Arg Lys 
            260                 265                 270         


Glu Ile Glu Gln Leu Lys Ser Asn Ile Glu Gly Tyr Lys Gly Lys Val 
        275                 280                 285             


Leu Asn Ile Glu Thr Glu Val Asp Arg Lys His Asn Ser Leu Lys Tyr 
    290                 295                 300                 


Met Ala Thr His Trp Val Phe Ser Ile Leu Ala Phe Lys Gly Leu Lys 
305                 310                 315                 320 


Gln Arg Leu Thr Asn Ser Phe Lys Lys Glu Ser Leu Leu Ile Gln Met 
                325                 330                 335     


Met Asp Glu Leu Asn Lys Val Pro Asp Glu Leu Tyr Gln Thr Leu Ser 
            340                 345                 350         


Glu Thr Ser Lys Lys Glu Phe Leu Glu Asp Ile Asn Glu Tyr Val Ser 
        355                 360                 365             


Glu Gly Asp Asp Asp Glu Lys Ala Thr Tyr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Ser Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gln Phe Pro Thr Leu Lys Phe Gln Ile Phe Val Gly 
                405                 410                 415     


Gln Tyr Leu His Asp Asn Arg Pro Lys Thr Leu Ala Ser Asn Gly Met 
            420                 425                 430         


Thr Ala Gln Arg Met Ile Lys Glu Lys Ile Asn Leu Phe Gly Asn Leu 
        435                 440                 445             


Ser Glu Val Thr Lys His Lys Ser Asp Phe Phe Glu Lys Glu Ser Ala 
    450                 455                 460                 


Val Gln Gly Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Trp Ala Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Val Tyr Ile Asp Leu Ile Gly Lys Glu Gly Lys Ala 
                485                 490                 495     


Lys Glu Ile Gln Val Gln Ile Asn Lys Tyr Arg Lys Gln Leu Asn Pro 
            500                 505                 510         


Ala Pro Gln Arg Asp Lys Arg Ile Ser Lys Lys Glu Ile Ile Glu Gln 
        515                 520                 525             


Leu Tyr Lys Glu Lys Val Val Tyr Gly Asp Pro Thr Leu Met Leu Ser 
    530                 535                 540                 


Ala Asn Glu Leu Met Ala Leu Leu Tyr Glu Leu Ile Val Asn Gly Lys 
545                 550                 555                 560 


Ser Gly Ala Glu Leu Glu Asn Lys Ile Val Glu Gln Ile Ile Ala Arg 
                565                 570                 575     


Tyr Glu Gln Ile Glu Ala Tyr Asp Pro Thr Thr Gln Gln Leu Pro Ala 
            580                 585                 590         


Asn Gln Met Pro His Lys Leu Gln Lys Ser Arg Lys Asp Ser Glu Val 
        595                 600                 605             


Ile Asp Thr Asp Lys Leu Leu Lys Ala Ile Asp Lys Glu Ile Asp Glu 
    610                 615                 620                 


Gly Asn Lys Lys Leu Glu Leu Ile Ala Cys His Arg Lys Glu Trp Glu 
625                 630                 635                 640 


Glu Ala Glu Gln Arg Lys Glu Ser Glu Lys Arg Asn Asn Pro Gly Thr 
                645                 650                 655     


Lys Ser Arg Lys Tyr Leu Phe Tyr Ala Ser Glu Met Gly Glu Glu Ala 
            660                 665                 670         


Thr Trp Ile Ala Asn Asp Leu Lys Arg Phe Met Pro Ile Pro Ala Arg 
        675                 680                 685             


Ala Glu Trp Lys Gly Thr His His Ser Glu Leu Gln Arg Leu Leu Ala 
    690                 695                 700                 


Phe Tyr Asn Thr Gln Arg Leu Glu Ala Trp Gln Leu Val Glu Ser Val 
705                 710                 715                 720 


Trp Thr Ala Asn Thr His Ser Phe Trp Glu Glu Asn Phe Lys Glu Ala 
                725                 730                 735     


Phe Tyr Lys Pro Glu Phe Glu Asn Phe Tyr Gly Ala Tyr Ile Lys Ile 
            740                 745                 750         


Arg Thr Lys Ile Leu Thr Thr Cys Arg Asn Phe Val Glu Asn Asn Pro 
        755                 760                 765             


Glu Val Thr Ile Asn Lys His Thr Arg Lys Glu Trp Asp Lys Val Phe 
    770                 775                 780                 


Thr Leu Phe Asp Lys Arg Leu Phe Arg Ile Asn Thr Thr Asp Glu Gln 
785                 790                 795                 800 


Lys Lys Gln Leu Leu Ala Lys Pro Phe Ala Phe Pro Arg Gly Leu Phe 
                805                 810                 815     


Asp Asp Lys Pro Thr Phe Leu Pro Gly Ser Lys Pro Asn Glu Asn Pro 
            820                 825                 830         


Glu Arg Phe Ala Ala Trp Tyr Ser Tyr Gly Tyr Ile Tyr Ser Gly Lys 
        835                 840                 845             


Phe Gln Ser Phe Tyr Asp Met Pro Arg Asp Tyr Ser Asp Trp Tyr Lys 
    850                 855                 860                 


Lys Leu Lys Glu Asp Gly Lys Leu Pro Pro Leu Asp Lys Lys Thr Glu 
865                 870                 875                 880 


Gln Glu Lys Ile Leu Arg Phe Arg Met Asp Cys Asp Leu Asn Ile Lys 
                885                 890                 895     


Tyr Ile Arg Phe Gln Asp Ile Tyr Val Lys Leu Met Val Asp Ser Leu 
            900                 905                 910         


Tyr Lys Ala Val Phe Gly Gln Gln Pro Glu Phe Asp Leu Ser His Leu 
        915                 920                 925             


Tyr Asp Thr Arg Tyr Glu Arg Tyr Glu Asn Asn Thr Ile Ala Gln Arg 
    930                 935                 940                 


Gln Lys Asn Arg Gln Glu Gly Asp Asn Ser Asp Asn Ala Ile Asn Glu 
945                 950                 955                 960 


Asn Tyr Val Trp Asn Lys Thr Phe Ala Ile Ser Leu Tyr Asn Gly Arg 
                965                 970                 975     


Ile Thr Glu Pro Gln Val Lys Leu Lys Asp Val Gly Lys Phe Arg Arg 
            980                 985                 990         


Phe Ala Ala Asp Pro Arg Val Gln  Thr Leu Ile Ser Tyr  Asp Asp Thr 
        995                 1000                 1005             


Arg Thr  Trp Thr Lys Leu Glu  Ile Glu Asn Glu Leu  Asp Asn Lys 
    1010                 1015                 1020             


Ala Asp  Ala Tyr Glu Pro Ile  Arg Arg Thr Gln Ser  Leu Lys Ala 
    1025                 1030                 1035             


Ile Gln  Gln Leu Glu Lys Asp  Ile Leu Lys Lys Asn  Gly Phe Asp 
    1040                 1045                 1050             


Gly Lys  Gln His Pro Glu Glu  Leu Lys His Asn Gly  Asn Pro Asn 
    1055                 1060                 1065             


Phe Arg  Lys Tyr Ile Ala Asn  Gly Leu Leu Lys His  Arg Thr Asp 
    1070                 1075                 1080             


Ile Arg  Gln Glu Glu Leu Ala  Leu Ile Ser Asp Thr  Glu Phe Gln 
    1085                 1090                 1095             


Glu Ile  Gly Leu Glu Arg Ile  Arg Gln Thr Asn Pro  Leu Ile Gln 
    1100                 1105                 1110             


Lys Ala  Tyr Leu Leu Ile Leu  Leu Arg Asn Lys Phe  Gly His Asn 
    1115                 1120                 1125             


Gln Leu  Pro Asp Gln Glu His  Phe Arg Leu Met Arg  Ser Ile Tyr 
    1130                 1135                 1140             


Pro Tyr  Asn Gln Gln Glu Ser  Tyr Ser Ala Tyr Phe  Asn Gln Val 
    1145                 1150                 1155             


Ile Thr  Gln Ile Ile Glu Glu  Leu Asn Thr 
    1160                 1165             


<210>  1614
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1614

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1615
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1615

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Val Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Ser Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asn Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1616
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1616

Met Glu Thr Lys Gln Gln Val Gly Lys Gly Ile Ser Tyr Asp His Arg 
1               5                   10                  15      


Arg Pro Asp Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asp Gly Val Ile Gln Glu Phe Ala Met Arg Leu Asn Arg 
        35                  40                  45              


Glu Tyr Asp Pro Glu Asn Lys Asn Gln Ser Leu Phe Ser Tyr Phe Asn 
    50                  55                  60                  


Ile Asn Ala Ser Phe Thr Asp Trp Glu Arg Gly Val Asn Ile Leu Lys 
65                  70                  75                  80  


Glu Tyr Trp Pro Met Met Glu Phe Ile Asp Arg Pro Ala Thr Asp Lys 
                85                  90                  95      


Gln Phe Glu Ala Glu Lys Pro Glu Asn Arg Glu Ala Ala Lys Arg Lys 
            100                 105                 110         


Tyr Phe Leu Ala Thr Leu Gly Ala Leu Leu Thr Ser Ile Lys Asp Leu 
        115                 120                 125             


Arg His Tyr Tyr Thr His Tyr Tyr His Pro Pro Val His Leu Asn Asp 
    130                 135                 140                 


Asp Leu Phe Leu Phe Leu Asp His Ala Leu Leu Tyr Thr Ala Phe Asp 
145                 150                 155                 160 


Val Lys Lys Thr Lys Met Lys Asp Asp Lys Thr Arg Gln Leu Leu Asn 
                165                 170                 175     


Gln Asn Leu Ser Leu Glu Leu Glu Lys Leu Lys Lys Leu Lys Val Glu 
            180                 185                 190         


Glu Leu Lys Lys Lys Lys Glu Lys Gly Ile Lys Val Asn Leu Gln Asp 
        195                 200                 205             


Glu Lys Gly Ile Leu Asn Ala Ile Tyr Asn Asp Ala Phe Ala His Ile 
    210                 215                 220                 


Ile Thr Lys Glu Lys Asp Ser Asp Lys Asp Lys Leu Glu Thr Arg Tyr 
225                 230                 235                 240 


Lys Ser Ile Leu Pro Gln Asp Glu Ala Ala Glu Thr Gly Ile Asn Ile 
                245                 250                 255     


Ser Ile Ser Gly Leu Ile Phe Leu Leu Ser Leu Phe Leu Ser Arg Lys 
            260                 265                 270         


Glu Ile Glu Gln Leu Lys Ser Asn Ile Glu Gly Tyr Lys Gly Lys Val 
        275                 280                 285             


Leu Asn Ile Glu Thr Glu Val Asp Arg Lys His Asn Ser Leu Lys Tyr 
    290                 295                 300                 


Met Ala Thr His Trp Val Phe Ser Ile Leu Ala Phe Lys Gly Leu Lys 
305                 310                 315                 320 


Gln Arg Leu Thr Asn Ser Phe Glu Lys Glu Ser Leu Leu Ile Gln Met 
                325                 330                 335     


Met Asp Glu Leu Asn Lys Val Pro Asp Glu Leu Tyr Gln Thr Leu Ser 
            340                 345                 350         


Glu Thr Ala Lys Lys Glu Phe Leu Glu Asp Ile Asn Glu Tyr Val Ser 
        355                 360                 365             


Glu Gly Asp Asp Asn Glu Lys Ala Thr Tyr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Ser Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gln Phe Pro Thr Leu Lys Phe Gln Ile Phe Val Gly 
                405                 410                 415     


Gln Tyr Leu His Asp Asn Arg Pro Lys Thr Leu Ala Ser Asn Gly Met 
            420                 425                 430         


Thr Ala Gln Arg Met Ile Lys Glu Lys Ile Asn Leu Phe Gly Asn Leu 
        435                 440                 445             


Ser Glu Val Thr Lys His Lys Ser Asp Phe Phe Glu Lys Glu Ser Ala 
    450                 455                 460                 


Ala Gln Gly Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Trp Ala Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Val Tyr Ile Asp Met Ile Gly Lys Glu Gly Lys Ala 
                485                 490                 495     


Lys Glu Ile Gln Val Gln Ile Asn Lys Tyr Arg Lys Gln Leu Asn Pro 
            500                 505                 510         


Ala Pro Gln Arg Asp Lys Arg Ile Ser Lys Lys Glu Ile Ile Glu Gln 
        515                 520                 525             


Leu Tyr Lys Glu Lys Val Val Tyr Gly Asp Pro Thr Leu Met Leu Ser 
    530                 535                 540                 


Ala Asn Glu Leu Met Ala Leu Leu Tyr Glu Leu Ile Val Asn Gly Lys 
545                 550                 555                 560 


Ser Gly Ala Glu Leu Glu Asn Lys Ile Val Glu Gln Ile Ile Ala Arg 
                565                 570                 575     


Tyr Glu Gln Ile Glu Ala Tyr Asp Pro Thr Thr Gln Gln Leu Pro Thr 
            580                 585                 590         


Asn Gln Met Pro His Lys Leu Gln Lys Ser Arg Lys Asp Ser Lys Val 
        595                 600                 605             


Thr Asp Thr Asp Lys Leu Leu Lys Thr Ile Asp Lys Glu Ile Asp Glu 
    610                 615                 620                 


Gly Asn Lys Lys Leu Glu Leu Ile Ala Cys His Arg Lys Glu Trp Glu 
625                 630                 635                 640 


Glu Ala Glu Gln Arg Lys Lys Ser Gly Lys Arg Asn Asn Pro Gly Thr 
                645                 650                 655     


Lys Ser Arg Lys His Leu Phe Tyr Ala Ser Glu Met Gly Glu Glu Ala 
            660                 665                 670         


Thr Trp Ile Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Pro Ala Arg 
        675                 680                 685             


Ala Glu Trp Lys Gly Thr His His Ser Glu Leu Gln Arg Leu Leu Ala 
    690                 695                 700                 


Phe Tyr Ser Thr Gln Arg Leu Glu Ala Trp Gln Leu Val Glu Ser Val 
705                 710                 715                 720 


Trp Thr Ala Asn Thr His Ser Phe Trp Glu Glu Asn Phe Lys Glu Ala 
                725                 730                 735     


Phe Tyr Lys Pro Glu Phe Glu Asn Phe Tyr Gly Ala Tyr Ile Glu Ile 
            740                 745                 750         


Arg Thr Lys Ile Leu Thr Thr Cys Arg Ser Ile Leu Glu Asn Asn Pro 
        755                 760                 765             


Glu Ala Thr Met Asn Asn Asp Thr Glu Lys Glu Trp Asp Lys Val Phe 
    770                 775                 780                 


Thr Leu Phe Asp Lys Arg Leu Tyr Arg Thr Ser Thr Thr Asp Glu Gln 
785                 790                 795                 800 


Lys Lys Gln Leu Leu Thr Lys Pro Phe Ala Phe Pro Arg Gly Leu Phe 
                805                 810                 815     


Asp Asp Lys Pro Thr Phe Leu Pro Gly Ser Lys Pro Asn Glu Asn Pro 
            820                 825                 830         


Glu Arg Phe Ala Ala Trp Tyr Ser Tyr Gly Tyr Thr Tyr Ser Gly Lys 
        835                 840                 845             


Phe Gln Ser Phe Tyr Asp Met Pro Arg Asn Tyr Ser Asp Trp Tyr Lys 
    850                 855                 860                 


Lys Leu Lys Glu Asp Gly Lys Leu Pro Arg Leu Asp Lys Lys Thr Glu 
865                 870                 875                 880 


Gln Glu Lys Ile Leu Arg Phe Arg Met Asp Cys Asp Leu Asn Ile Lys 
                885                 890                 895     


His Ile Arg Phe Gln Asp Ile Tyr Val Lys Leu Met Val Asp Ser Leu 
            900                 905                 910         


Tyr Lys Ala Val Phe Gly Gln Gln Pro Glu Phe Asp Leu Ser His Leu 
        915                 920                 925             


Tyr Asp Thr Arg Ser Glu Arg Tyr Glu Asn Asn Thr Ile Ala Gln Arg 
    930                 935                 940                 


Gln Lys Ser Arg Gln Glu Gly Asp Asn Ser Asp Asn Ala Ile Asn Glu 
945                 950                 955                 960 


Asn Tyr Val Trp Asn Lys Thr Phe Ala Ile Ser Leu Tyr Asn Gly Arg 
                965                 970                 975     


Ile Thr Glu Ser Gln Val Lys Leu Lys Asp Val Gly Lys Phe Arg Arg 
            980                 985                 990         


Phe Ala Thr Asp Pro Arg Val Gln  Thr Leu Ile Ser Tyr  Asp Asp Thr 
        995                 1000                 1005             


Arg Thr  Trp Thr Lys Leu Glu  Ile Glu Asn Glu Leu  Asp Asn Lys 
    1010                 1015                 1020             


Ala Asp  Ala Tyr Glu Pro Ile  Arg Arg Thr Gln Ser  Leu Lys Ala 
    1025                 1030                 1035             


Ile Gln  Gln Leu Glu Lys Asn  Ile Leu Lys Lys Asn  Gly Phe Asn 
    1040                 1045                 1050             


Gly Lys  Gln His Pro Glu Glu  Leu Lys His Asn Gly  Asn Pro Asn 
    1055                 1060                 1065             


Phe Arg  Lys Tyr Ile Ala Asn  Gly Leu Leu Lys His  Arg Thr Asp 
    1070                 1075                 1080             


Ile Arg  Gln Glu Glu Leu Ala  Leu Ile Ser Asp Thr  Glu Phe Gln 
    1085                 1090                 1095             


Glu Ile  Gly Leu Glu Arg Ile  Arg Gln Thr Asn Pro  Leu Ile Gln 
    1100                 1105                 1110             


Lys Ala  Tyr Leu Leu Ile Leu  Leu Arg Asn Lys Phe  Gly His Asn 
    1115                 1120                 1125             


Gln Leu  Pro Asp Gln Glu His  Phe Arg Leu Met Arg  Ser Ile Tyr 
    1130                 1135                 1140             


Pro Tyr  Asn Gln Gln Glu Ser  Tyr Ser Ala Tyr Phe  Asn His Val 
    1145                 1150                 1155             


Ile Thr  Gln Ile Ile Glu Glu  Leu Asn Thr 
    1160                 1165             


<210>  1617
<211>  1094
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1617

Met Glu Ala Asn Glu Gln Asn Gln Glu Asn Arg Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Asn Asn His Ile Ala Ala Asp Phe Gly Gln Ala Val 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ser Gly Phe Leu Cys Asn Lys Glu 
    50                  55                  60                  


Ile Lys Lys Leu Asn Trp Asn His Ile Tyr Ala Lys Thr Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ile Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Val Asn Ser Asp Lys Glu Gly Lys Asp Phe Ala Ala Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Ser Glu Leu Gln Asp Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Glu Asn Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Ala Glu Leu Thr Asp Met Leu Thr Ile Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Thr Asp Ala Asp Tyr 
                165                 170                 175     


Glu Leu Val Glu Thr Lys Gln Val Val Thr Thr Gly Asn Ile Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Met Phe Leu Glu Arg Glu His 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asn Leu Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Gly 
            260                 265                 270         


Val Ile Thr Asp Glu Glu Lys Met Gln Phe Arg Pro Glu Leu Asp Glu 
        275                 280                 285             


Leu Asp Ile Glu Lys Leu Ile Ala Asn Ser Thr Asn Asp Asp Glu Arg 
    290                 295                 300                 


Glu Arg Ile Leu Asp Glu Ile Gly Tyr Glu Glu Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg Tyr Asn Asn Arg Phe Pro Tyr Phe Ala Met Arg 
                325                 330                 335     


Phe Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Arg Tyr Thr Lys Gln Leu Ala Gly Glu 
        355                 360                 365             


Gln Thr Glu Arg Val Val Gln Glu Asn Val Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asp Pro Glu Leu Ile Gln Gln Lys Ile Asp Asn Gln 
385                 390                 395                 400 


Gln Arg Thr Asp Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Ile Ala Ile Leu Ile 
            420                 425                 430         


Pro Lys Ser Lys Pro Glu Ser Lys Val Gly Asn Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Asp Tyr Leu Gln Lys Gly Lys Ala Glu Glu Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Ile Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Leu Lys Leu Pro Ala Asn Trp Asn Glu Phe Ala Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asp Ala Ala Met Glu Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Asp Val Leu Ile Thr Tyr Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Asp Val Glu Asp Asn Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Leu Glu Lys His Lys Leu 
            580                 585                 590         


Asp Lys Ser Val Lys Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Met Val Ser Lys Glu Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Ala Asp Thr Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Val Leu Glu Gly Asp Gly His Pro Phe Leu Thr Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Glu Leu Tyr Met Asn 
        675                 680                 685             


Ala Lys Val Gln Tyr Leu Ile Gln Phe Tyr Lys Pro Ser Lys Asp Lys 
    690                 695                 700                 


Val Asp Lys Arg Gly Arg Pro Thr Thr Glu Val Lys Leu Pro Pro Leu 
705                 710                 715                 720 


Asp Lys Arg Ser Asn Ile Pro Phe Thr Ile Arg Gln Trp Asp Glu Lys 
                725                 730                 735     


Glu Lys Tyr Asn Leu Asn Ala Trp Leu Arg Asn Val Thr Val Gly Lys 
            740                 745                 750         


Asn Thr Lys Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe 
        755                 760                 765             


Asp Glu Thr Leu Cys Asp Leu Leu Ser Gln Gln Leu Asp Ala Arg Thr 
    770                 775                 780                 


Val Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Leu Trp 
785                 790                 795                 800 


Trp Lys Thr Arg Asp Asp Ala Thr Gln Asp Phe Tyr Gln Ser Glu Arg 
                805                 810                 815     


Glu Tyr Asp Ile Tyr Glu Glu Lys Val Glu Phe Lys Ile Asp Ser Ser 
            820                 825                 830         


Gly His Phe Ala Asp Tyr Tyr Lys Lys Ala Leu Ser Lys Ala Tyr Asn 
        835                 840                 845             


Arg Leu Lys Ala Glu Arg Glu Ile Ala Arg Arg Thr Asn Lys Arg Leu 
    850                 855                 860                 


Pro Pro Ile Glu His Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile 
865                 870                 875                 880 


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
                885                 890                 895     


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asp Ser Gly Asn Leu Lys 
            900                 905                 910         


Leu Ser Thr Ile Lys Thr Ser Leu Asn Asn Thr Thr Gln Ile Lys Gln 
        915                 920                 925             


Lys Ile Leu Asn Lys Thr Ile Val Ala Glu Arg Lys Gln Lys Asn Tyr 
    930                 935                 940                 


Thr Glu Leu Arg Lys Tyr Val His Asp Arg Arg Leu Pro Asn Leu Phe 
945                 950                 955                 960 


Glu Tyr Val Glu Ala Asp Glu Ile Leu Leu Glu Trp Leu Leu Asp Glu 
                965                 970                 975     


Leu Met Ala Tyr Asn Ala Ala Lys Gln Gln Val Phe Asp Thr Ile Phe 
            980                 985                 990         


Met Leu Glu Lys Arg Ile Ile Glu  Thr Asp Pro Gln Glu  Leu Lys Ser 
        995                 1000                 1005             


Leu Phe  Thr Asn Glu Lys Gly  Gln Val Gln Thr Gly  Asn Ile Gln 
    1010                 1015                 1020             


His Lys  Pro Tyr Val Gln Trp  Leu Lys Asn Lys Gly  Leu Ile Asn 
    1025                 1030                 1035             


His Asn  Glu Lys Leu Phe Ile  Asn Met Val Arg Asn  Cys Phe Ser 
    1040                 1045                 1050             


His Asn  Gln Phe Pro Gln Arg  Glu Thr Met Glu Leu  Leu Ile Ser 
    1055                 1060                 1065             


Glu Trp  Gly Ala Gly Lys Ile  Ala Thr Gln Ile Leu  Thr Val Tyr 
    1070                 1075                 1080             


Asn Gln  Leu Ile Thr Asn Ile  Ile Asn Lys Ile 
    1085                 1090                 


<210>  1618
<211>  1175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1618

Met Thr Glu Gln Asn Glu Arg Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Ala His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Cys His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Lys Tyr Gly Asn Asn Asp Asn Pro Phe Phe Lys Tyr His Phe Val Asp 
    210                 215                 220                 


Arg Glu Gly Lys Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Thr Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Phe Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Asp Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Asp Glu Ile Asn Thr Leu Asp 
    530                 535                 540                 


Arg Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Ile Arg Lys Lys Leu Gln Glu Met Met Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Gly Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Leu Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asn Tyr Pro Phe Asn Val Gly Asn Ile Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Asp Leu Glu Ala Trp Ser Gln Ser Thr Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Ala Gly Ile Lys Tyr Ala Ser Pro Gly Asn 
    850                 855                 860                 


Lys Lys Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Glu Thr 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Lys Ala Asp Lys Ile Asn Leu Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Ala Lys Glu His Pro Tyr Leu Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Met 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asp Ile Arg Thr 
945                 950                 955                 960 


Asp Val Gln Glu Gln Gly Ser Leu Asn Val Leu Asn His Val Lys Pro 
                965                 970                 975     


Met Arg Leu Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val 
            980                 985                 990         


His Lys Glu Glu Ala Pro Leu Ala  Thr Val Tyr Ile Glu  Glu Arg Asp 
        995                 1000                 1005             


Thr Lys  Leu Leu Lys Gln Gly  Asn Phe Lys Ser Phe  Val Lys Asp 
    1010                 1015                 1020             


Arg Arg  Leu Asn Gly Leu Phe  Ser Phe Val Asp Thr  Gly Ala Leu 
    1025                 1030                 1035             


Ala Met  Glu Gln Tyr Pro Ile  Ser Lys Leu Arg Val  Glu Tyr Glu 
    1040                 1045                 1050             


Leu Ala  Lys Tyr Gln Thr Ala  Arg Val Cys Ala Phe  Glu Gln Thr 
    1055                 1060                 1065             


Leu Glu  Leu Glu Glu Ser Leu  Leu Thr Arg Tyr Pro  His Leu Pro 
    1070                 1075                 1080             


Asp Lys  Asn Phe Arg Lys Met  Leu Glu Ser Trp Ser  Asp Pro Leu 
    1085                 1090                 1095             


Leu Asp  Lys Trp Pro Asp Leu  His Arg Lys Val Arg  Leu Leu Ile 
    1100                 1105                 1110             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1115                 1120                 1125             


Glu Ala  Val Phe Ser Ser Ile  Arg Lys Tyr Asp Pro  Ser Ser Pro 
    1130                 1135                 1140             


Asp Ala  Ile Glu Glu Arg Met  Gly Leu Asn Ile Ala  His Arg Leu 
    1145                 1150                 1155             


Ser Glu  Glu Val Lys Gln Ala  Lys Glu Thr Val Glu  Arg Ile Ile 
    1160                 1165                 1170             


Gln Ala  
    1175 


<210>  1619
<211>  1224
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1619

Met Asp Ile Arg Leu Ser Lys Asn Arg Ala Leu Leu Ala Ala Tyr Leu 
1               5                   10                  15      


Asn Met Ala Gln Gln Asn Val Tyr Val Thr Leu Leu His Ile Ser Gln 
            20                  25                  30          


Leu Met Gly Val Glu Glu Thr Lys Asp Leu Ser Asn Arg Met Tyr Asp 
        35                  40                  45              


Phe Gln Ile Leu Gln Glu Leu Lys Thr Gly Lys Lys Gly Ala Glu Ser 
    50                  55                  60                  


Glu Gln Met Val Lys Ser Glu Arg Val Gln Lys Ile Ile Leu Leu Leu 
65                  70                  75                  80  


Tyr Arg Asn Phe Pro Phe Leu Lys Ala Phe Val Glu Ala Lys Tyr Lys 
                85                  90                  95      


Gln Gln Glu Lys Asn Asn Gly Gly Lys Asn Lys Gly Gly Gly Lys Asn 
            100                 105                 110         


Thr Gln Lys Asn Lys Lys Thr Pro Asp Asn Thr Ser Asn Glu Glu Gln 
        115                 120                 125             


Leu Glu Phe Thr Glu Ser Glu Leu Gly Lys Leu Pro Ile Pro Pro His 
    130                 135                 140                 


Glu Tyr Arg Thr Ile Leu Cys Asp Val Phe Arg Leu Ile Asn Asp Leu 
145                 150                 155                 160 


Arg Asn Glu Tyr Thr His Phe Ser Pro Glu Lys Arg Thr Gly Gly Ala 
                165                 170                 175     


Lys Glu Ser His Glu Lys Cys Gln Lys Lys Met Leu Ser Tyr Leu Tyr 
            180                 185                 190         


Leu Cys Leu Asp Gly Gly Arg Arg Val Val Lys Glu Arg Phe Lys Asp 
        195                 200                 205             


Thr Phe Gln Glu Lys Asp Phe Asn Phe Leu Thr Gln Gly Pro Arg Tyr 
    210                 215                 220                 


Ser Leu Gln Lys Asp Gly Asp Lys Lys Lys Ala Glu Glu Arg Pro Asn 
225                 230                 235                 240 


Phe Tyr Tyr Arg Leu Lys Asp Asp Gln Gly Leu Phe Ser Tyr Val Gly 
                245                 250                 255     


Ile Leu Leu Phe Ile Ser Leu Phe Leu His Lys Arg Tyr Ile Ser Glu 
            260                 265                 270         


Met Leu Ala Gln Ser Gly Leu Phe Tyr Thr Pro Arg Tyr Trp Lys Gly 
        275                 280                 285             


Gln Pro Val Asn Val Glu Leu Glu Arg Arg Ile Ile Ser Glu Ile Phe 
    290                 295                 300                 


Ser Ile Tyr Arg Ile Arg Leu Pro Lys Glu Arg Ile Asp Ser Thr Arg 
305                 310                 315                 320 


Pro Asp Tyr Ala Leu Gly Leu Asp Met Leu Asn Glu Leu Gln Lys Cys 
                325                 330                 335     


Pro Asn Glu Leu Tyr Glu Thr Phe Ser Pro Lys Asp Gln Ala Glu Phe 
            340                 345                 350         


Arg Val Lys Arg Glu Tyr Asp Glu Ser Gly Glu Gly Thr Glu Glu Gly 
        355                 360                 365             


Glu Val Leu Leu Lys Arg Phe Glu Asp Arg Phe Pro Tyr Phe Ala Ile 
    370                 375                 380                 


Arg Tyr Leu Asp Glu Asn Arg Val Phe Asp Asp Ile Arg Phe Gln Val 
385                 390                 395                 400 


Ser Ile Gly Lys Tyr Arg Tyr Lys Phe Tyr Asn Lys Leu Cys Ile Asp 
                405                 410                 415     


Val Val Ser Ser Asn Arg Asn Asp Asp Cys Tyr Arg Leu Arg Ser Leu 
            420                 425                 430         


Gln Lys Glu Ile Asn Gly Phe Gly Arg Leu Asn Glu Val Glu Tyr Glu 
        435                 440                 445             


Arg Ile Leu Arg Tyr Gly Ser His Ile His Val Glu Lys Pro Glu Gly 
    450                 455                 460                 


Asp Asp Thr Pro Tyr Leu Thr Asp His His Thr Ser Tyr Leu Phe Asn 
465                 470                 475                 480 


Gly Asn Arg Ile Gly Leu Leu Phe Asn Gln Glu Asn Gly Arg His Asp 
                485                 490                 495     


Leu Glu Glu Ile Arg Gly Asn Cys Leu Tyr Leu Pro His Leu Thr Phe 
            500                 505                 510         


Ala Ser Ser Ser Glu Gly Lys Asp Ala Arg Arg Val Pro Pro Ile Ala 
        515                 520                 525             


Trp Leu Ser Thr Tyr Glu Leu Pro Ala Leu Ile Phe His His Leu Leu 
    530                 535                 540                 


Cys Arg His Tyr Gly Leu Glu Arg Thr Ala Thr Glu Ser Ile Ile Lys 
545                 550                 555                 560 


Glu Cys Val Gly Leu Tyr His Arg Leu Phe Thr Asp Ile Arg Asp Gly 
                565                 570                 575     


Lys Leu Leu Pro Gly Glu Ala Leu Gly Ile Gln Ala Glu Glu Ser Thr 
            580                 585                 590         


Arg Ser Glu Ile Ser Arg Ile Lys Lys Gly Glu Pro Leu Pro Gln Asn 
        595                 600                 605             


Ile Ser Glu Lys Ile Glu Thr Phe Leu Ser Thr His Tyr Cys Thr Glu 
    610                 615                 620                 


Gln Val Cys Leu His Ile Gln Asp Ile Pro Lys Lys Ile Ile Asp Tyr 
625                 630                 635                 640 


Leu Ile Gly Lys Asn Ile Asp Gln Asp Met Ser Gly Leu Phe Lys Gln 
                645                 650                 655     


Arg Ser Arg Glu Arg Ile Asn Lys Met Tyr Glu Ser Thr Lys Ile Arg 
            660                 665                 670         


Leu Lys Lys Phe Lys Thr Asp Leu Asp Leu Gln Gly Asn Gly Asp Asn 
        675                 680                 685             


Lys Phe Gly Lys Lys Arg Tyr Thr Asp Ile Arg Pro Gly Gln Leu Ala 
    690                 695                 700                 


Asp Tyr Leu Ala Lys Asp Leu Leu Phe Phe Gln Pro Tyr Asp Asp Glu 
705                 710                 715                 720 


Lys Lys Asn Lys Val Thr Gly Leu Asn Tyr Gln Ile Leu Gln Ala Ala 
                725                 730                 735     


Leu Ala Ile Tyr Asn His Asn Leu Asp Glu Leu Arg Arg Leu Phe Lys 
            740                 745                 750         


Asn Ala Arg Leu Leu Val Pro Glu Asn Pro Lys Met Glu His Pro Phe 
        755                 760                 765             


Leu Gly Ser Val Leu His Lys Ser Pro Arg Thr Thr Leu Gln Phe Tyr 
    770                 775                 780                 


Ala Tyr Tyr Leu Leu Glu Lys Ile Ser Tyr Leu Lys Lys Arg Leu Asp 
785                 790                 795                 800 


Asp Pro Asn Glu Thr Phe Ala Asp Leu Phe Arg Tyr Lys Gln Arg Gln 
                805                 810                 815     


Lys Trp Gln Thr Arg Asp Ser Gln Trp Tyr Arg Ala Leu Ala Gly Arg 
            820                 825                 830         


Tyr Met Ala Glu Met Met Glu Glu Gly Thr Met Asn Phe Lys Pro Val 
        835                 840                 845             


Glu Leu Pro Arg Gly Leu Phe Glu Arg Pro Ile Lys Arg Leu Leu Thr 
    850                 855                 860                 


Asn Ile Leu Thr Lys Arg Thr Asp Ser Asp Ser Gln Ala Leu Leu Lys 
865                 870                 875                 880 


Ile Val Glu Ser Pro Arg Cys Asn Val Ser Tyr Leu Ile Ala Gln Tyr 
                885                 890                 895     


Phe Thr Leu Ile Leu His Asp Asp Ser Gln Pro Phe Tyr His Pro Asn 
            900                 905                 910         


Lys Arg Tyr Lys Arg Thr Tyr Gln Tyr Phe Asn Ile Leu Asn Asn Arg 
        915                 920                 925             


Lys Glu Arg Asn Lys Leu Val Gln Val Tyr Tyr Thr Leu Asp Glu Met 
    930                 935                 940                 


Glu Ala Tyr Phe Lys Asp Thr Glu Ser Leu Lys Lys Arg Tyr Lys Asp 
945                 950                 955                 960 


Tyr Leu Thr Ser Ser Glu Ala Lys Lys His Pro Ala Pro Glu Gln Arg 
                965                 970                 975     


Leu Lys Lys Tyr Leu Ser Glu Tyr Arg Lys Asn Glu Thr Thr Ile Arg 
            980                 985                 990         


Arg Tyr Arg Val Gln Asp Met Leu  Val Phe Leu Met Ala  Lys Ile Leu 
        995                 1000                 1005             


Leu Leu  Glu Lys Gly Gly Leu  Glu Ala Gly Glu Leu  Glu Gln Tyr 
    1010                 1015                 1020             


Lys Leu  Ser His Ile Gln Pro  Thr Thr Gly Gln Asn  Ser Gly Gln 
    1025                 1030                 1035             


Asn Ile  Leu Ser Leu Gln Val  Pro Phe Asn Ile Thr  Val Lys Leu 
    1040                 1045                 1050             


Asp Asp  Gly Thr Glu Arg Ser  Ile Thr Gln Glu Val  Ile Lys Val 
    1055                 1060                 1065             


Lys Asn  Tyr Gly Asp Phe Phe  Arg Phe Leu Tyr Asp  Asp Arg Val 
    1070                 1075                 1080             


Ala Ser  Leu Leu Pro Tyr Thr  Gln Glu Asp Ile Pro  Leu Glu Arg 
    1085                 1090                 1095             


Ala Leu  Leu Glu Lys Glu Leu  Glu Gly Tyr Asp Arg  Glu Arg Ile 
    1100                 1105                 1110             


Pro Ile  Phe Lys Ser Val His  Cys Met Glu Lys Glu  Ile Leu Arg 
    1115                 1120                 1125             


Leu Cys  Pro Glu Leu Asn Asp  Pro Gln Ser Ser Gln  Tyr Lys Tyr 
    1130                 1135                 1140             


Thr Thr  Asp Ile Gly Thr Glu  Lys Ile Val Lys Glu  Asn Phe Arg 
    1145                 1150                 1155             


Ala Met  Leu Thr Glu Leu Cys  Ser Arg Gly Leu Leu  Pro Glu Asn 
    1160                 1165                 1170             


Glu Ile  Glu Met Met Val Glu  Ile Arg Asn Ser Phe  Ser His Asn 
    1175                 1180                 1185             


Arg Tyr  Ala Cys Val Asn Leu  Lys Gly Lys Asn Ile  Pro Met Ile 
    1190                 1195                 1200             


Ala Ile  Ser Ile Gln Arg Lys  Phe Asp Gly Val Val  Gly Arg Thr 
    1205                 1210                 1215             


Ile Gly  Lys Asn Lys Asn 
    1220                 


<210>  1620
<211>  1119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1620

Met Thr Glu Gln Asn Glu Arg Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Thr His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Tyr Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Glu Lys Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Ala Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Cys Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Ala 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Leu Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Glu Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Gly Glu Ile Asp Thr Leu Asp 
    530                 535                 540                 


Arg Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Ser Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly His Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Leu Ala Lys Leu Lys Lys Glu Ile Leu Glu Ala 
        835                 840                 845             


Lys Glu His Pro Tyr Leu Asp Phe Lys Ser Trp Gln Lys Phe Glu Arg 
    850                 855                 860                 


Glu Leu Arg Leu Val Lys Asn Gln Asp Ile Ile Thr Trp Met Ile Cys 
865                 870                 875                 880 


Arg Asp Leu Met Glu Glu Asn Lys Val Glu Gly Leu Asp Thr Gly Thr 
                885                 890                 895     


Leu Tyr Leu Lys Asp Ile Arg Thr Asp Val Gln Glu Gln Gly Ser Leu 
            900                 905                 910         


Asn Val Leu Asn Arg Val Lys Pro Met Arg Leu Pro Val Val Val Tyr 
        915                 920                 925             


Arg Ala Asp Ser Arg Gly His Val His Lys Glu Gln Ala Pro Leu Ala 
    930                 935                 940                 


Thr Val Tyr Ile Glu Glu Arg Asp Thr Lys Leu Leu Lys Gln Gly Asn 
945                 950                 955                 960 


Phe Lys Ser Phe Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe 
                965                 970                 975     


Val Asp Thr Gly Ala Leu Ala Met Glu Gln Tyr Pro Ile Ser Lys Leu 
            980                 985                 990         


Arg Val Glu Tyr Glu Leu Ala Lys  Tyr Gln Thr Ala Arg  Val Cys Ala 
        995                 1000                 1005             


Phe Glu  Gln Thr Leu Glu Leu  Glu Glu Ser Leu Leu  Thr Arg Cys 
    1010                 1015                 1020             


Pro His  Leu Pro Asp Lys Asn  Phe Arg Lys Met Leu  Glu Ser Trp 
    1025                 1030                 1035             


Ser Asp  Pro Leu Leu Asp Lys  Trp Pro Asp Leu His  Arg Lys Val 
    1040                 1045                 1050             


Arg Leu  Leu Ile Ala Val Arg  Asn Ala Phe Ser His  Asn Gln Tyr 
    1055                 1060                 1065             


Pro Met  Tyr Asp Glu Ala Val  Phe Ser Ser Ile Arg  Lys Tyr Asp 
    1070                 1075                 1080             


Pro Ser  Phe Pro Asp Ala Ile  Glu Glu Arg Met Gly  Leu Asn Ile 
    1085                 1090                 1095             


Ala His  Arg Leu Ser Glu Glu  Val Lys Gln Ala Lys  Glu Thr Val 
    1100                 1105                 1110             


Glu Arg  Ile Ile Gln Ala 
    1115                 


<210>  1621
<211>  987
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1621

Val Lys Met Glu Asp Asp Lys Lys Thr Lys Glu Ser Ile Ser Tyr Glu 
1               5                   10                  15      


Leu Glu Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His 
            20                  25                  30          


Asn Val Tyr Ile Thr Val Asn His Ile Asn Lys Val Leu Glu Leu Lys 
        35                  40                  45              


Asn Lys Lys Asp Gln Asp Ile Ile Ile Asp Asn Asp Gln Asp Ile Leu 
    50                  55                  60                  


Ala Ile Lys Thr His Trp Glu Lys Val Asp Gly Asp Leu Asn Lys Thr 
65                  70                  75                  80  


Glu Arg Leu Arg Glu Leu Met Thr Lys His Phe Pro Phe Leu Glu Thr 
                85                  90                  95      


Ala Ile Tyr Ser Lys Asn Lys Glu Asp Lys Glu Glu Val Lys Gln Glu 
            100                 105                 110         


Lys Gln Ala Lys Ala Gln Ser Phe Asp Ser Leu Lys His Cys Leu Phe 
        115                 120                 125             


Leu Phe Leu Glu Lys Leu Gln Glu Ala Arg Asn Tyr Tyr Ser His Tyr 
    130                 135                 140                 


Lys Tyr Ser Glu Ser Thr Lys Glu Pro Met Leu Glu Lys Glu Leu Leu 
145                 150                 155                 160 


Lys Lys Met Tyr Asn Ile Phe Asp Asp Asn Ile Gln Leu Val Ile Lys 
                165                 170                 175     


Asp Tyr Gln His Asn Lys Asp Ile Asn Pro Asp Glu Asp Phe Lys His 
            180                 185                 190         


Leu Asp Arg Thr Glu Glu Asp Phe Asn Tyr Tyr Phe Thr Arg Asn Lys 
        195                 200                 205             


Lys Gly Asn Ile Thr Glu Ser Gly Leu Leu Phe Phe Val Ser Leu Phe 
    210                 215                 220                 


Leu Glu Lys Lys Asp Ala Ile Trp Met Gln Gln Lys Leu Thr Gly Phe 
225                 230                 235                 240 


Lys Asp Asn Arg Glu Ser Lys Lys Lys Met Thr His Glu Val Phe Cys 
                245                 250                 255     


Arg Arg Arg Met Leu Leu Pro Lys Leu Arg Leu Glu Ser Thr Gln Thr 
            260                 265                 270         


Gln Asp Trp Ile Leu Leu Asp Met Leu Asn Glu Leu Ile Arg Cys Pro 
        275                 280                 285             


Lys Ser Leu Tyr Glu Arg Leu Gln Gly Val Asp Arg Glu Lys Phe Lys 
    290                 295                 300                 


Val Pro Phe Asp Pro Ala Asp Glu Asp Tyr Asp Ala Glu Gln Glu Pro 
305                 310                 315                 320 


Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Ala 
                325                 330                 335     


Leu Arg Tyr Phe Asp Tyr Asn Glu Val Phe Thr Asn Leu Arg Phe Gln 
            340                 345                 350         


Ile Asp Leu Gly Thr Tyr His Phe Ser Ile Tyr Lys Lys Leu Ile Gly 
        355                 360                 365             


Gly Gln Lys Glu Asp Arg His Leu Thr His Lys Leu Tyr Gly Phe Glu 
    370                 375                 380                 


Arg Ile Gln Glu Phe Ala Lys Gln Asn Arg Pro Asp Glu Trp Lys Ala 
385                 390                 395                 400 


Ile Val Lys Asp Leu Asp Thr Tyr Glu Thr Ser Asn Glu Arg Tyr Ile 
                405                 410                 415     


Ser Glu Thr Thr Pro His Tyr His Leu Glu Asn Gln Lys Ile Gly Ile 
            420                 425                 430         


Arg Phe Lys Asn Gly Asn Asn Asp Ile Trp Pro Ser Leu Glu Thr Asn 
        435                 440                 445             


Gly Glu Asn Asn Glu Lys Arg Lys Tyr Lys Leu Asp Lys Gln Tyr Gln 
    450                 455                 460                 


Ala Glu Ala Phe Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr 
465                 470                 475                 480 


Tyr Leu Leu Leu Lys Lys Glu Lys Pro Asn Asn Asp Glu Ile Asn Ala 
                485                 490                 495     


Ser Ile Val Glu Gly Phe Ile Lys Arg Glu Ile Arg Asp Ile Tyr Lys 
            500                 505                 510         


Leu Tyr Asp Ala Phe Ala Asn Gly Glu Ile Asn Asn Ile Asp Asp Leu 
        515                 520                 525             


Glu Lys Tyr Cys Glu Asp Lys Gly Ile Pro Lys Arg His Leu Pro Lys 
    530                 535                 540                 


Gln Met Val Ala Ile Leu Tyr Asp Glu His Lys Asp Met Val Lys Glu 
545                 550                 555                 560 


Ala Lys Arg Lys Gln Lys Glu Met Val Lys Asp Thr Lys Lys Leu Leu 
                565                 570                 575     


Ala Ala Leu Glu Lys Gln Thr Gln Glu Lys Thr Glu Asp Gly Gly Arg 
            580                 585                 590         


Asn Ile Arg Leu Leu Lys Ser Gly Glu Ile Ala Arg Trp Leu Val Asn 
        595                 600                 605             


Asp Met Met Arg Phe Gln Pro Val Gln Lys Asp Asn Glu Gly Asn Pro 
    610                 615                 620                 


Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln Met Leu Gln Arg 
625                 630                 635                 640 


Ser Leu Ala Leu Tyr Asn Lys Glu Glu Lys Pro Thr Arg Tyr Phe Arg 
                645                 650                 655     


Gln Val Asn Leu Ile Asn Ser Ser Asn Pro His Pro Phe Leu Lys Trp 
            660                 665                 670         


Thr Lys Trp Glu Glu Cys Asn Asn Ile Leu Ser Phe Tyr Arg Ser Tyr 
        675                 680                 685             


Leu Thr Lys Lys Ile Glu Phe Leu Asn Lys Leu Lys Pro Glu Asp Trp 
    690                 695                 700                 


Glu Lys Asn Gln Tyr Phe Leu Lys Leu Lys Glu Pro Lys Thr Asn Arg 
705                 710                 715                 720 


Glu Thr Leu Val Gln Gly Trp Lys Asn Gly Phe Asn Leu Pro Arg Gly 
                725                 730                 735     


Ile Phe Thr Glu Pro Ile Arg Glu Trp Phe Lys Arg His Gln Asn Asp 
            740                 745                 750         


Ser Glu Glu Tyr Glu Lys Val Glu Ala Leu Lys Arg Val Gly Leu Val 
        755                 760                 765             


Thr Lys Val Ile Pro Leu Phe Phe Lys Glu Glu Tyr Phe Lys Glu Asp 
    770                 775                 780                 


Ala Gln Lys Glu Ile Asn Asn Cys Val Gln Pro Phe Tyr Gly Phe Pro 
785                 790                 795                 800 


Tyr Asn Val Gly Asn Ile His Lys Pro Lys Glu Glu Asp Phe Leu His 
                805                 810                 815     


Arg Glu Glu Arg Ile Glu Leu Trp Asp Lys Lys Lys Asp Lys Phe Lys 
            820                 825                 830         


Gly Tyr Lys Ala Lys Lys Lys Phe Lys Glu Met Thr Asp Lys Glu Lys 
        835                 840                 845             


Glu Glu His Arg Ser Tyr Leu Glu Phe Lys Ser Trp Asn Gln Phe Glu 
    850                 855                 860                 


Arg Glu Leu Arg Leu Val Arg Asn Gln Asp Ile Val Thr Trp Leu Leu 
865                 870                 875                 880 


Cys Met Glu Leu Ile Asp Lys Leu Lys Val Glu Gly Leu Asn Val Glu 
                885                 890                 895     


Glu Leu Gln Lys Leu Arg Leu Lys Asp Ile Asp Thr Asp Thr Ala Lys 
            900                 905                 910         


Gln Glu Lys Asn Asn Ile Leu Asn Arg Val Met Pro Met Gln Leu Pro 
        915                 920                 925             


Val Thr Val Tyr Glu Ile Asp Asp Ser His Asn Ile Val Lys Asp Arg 
    930                 935                 940                 


Pro Leu His Thr Val Tyr Ile Glu Glu Thr Lys Thr Lys Leu Leu Lys 
945                 950                 955                 960 


Gln Gly Asn Phe Lys Ala Leu Val Lys Asp Arg Arg Leu Asn Gly Leu 
                965                 970                 975     


Phe Ser Phe Val Asp Thr Ser Ser Glu Ala Glu 
            980                 985         


<210>  1622
<211>  1093
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1622

Met Glu Lys Gln Ser Lys Tyr Leu Phe Ala Ala Tyr Leu Asn Met Ala 
1               5                   10                  15      


Arg His Asn Ala Phe Ile Thr Leu Ser Tyr Ile Ser Thr Ser Ile Gly 
            20                  25                  30          


Gly Thr Glu Gly Ser Glu Asp Asn Leu Ser Asp Met Leu Pro Val Arg 
        35                  40                  45              


Val Leu Thr Asp Arg Lys Ala Glu Pro Glu Lys Ile Lys Arg Thr Met 
    50                  55                  60                  


Glu Leu Leu Asp Lys His Phe Pro Phe Leu Lys Pro Met Leu Asn Lys 
65                  70                  75                  80  


Glu Leu Arg Pro Asp Glu Lys Ser Asp Lys Lys Glu Val Gly Thr Met 
                85                  90                  95      


Ala Ser Pro Glu Asn Tyr Gln Thr Val Leu Lys Thr Ala Phe Lys Glu 
            100                 105                 110         


Leu Asn Ser Gln Arg Asn Gln Tyr Thr His Phe Lys His Glu Arg Lys 
        115                 120                 125             


Asp Phe Asp Arg Asn Leu Ile Glu Tyr Met Lys Asn Cys Phe Asp Gly 
    130                 135                 140                 


Ala Lys Arg Val Ala Lys Glu Arg Phe Lys Leu Glu Asp Arg Asp Ile 
145                 150                 155                 160 


Glu His Leu Asn Arg Phe Arg Lys Lys Lys Glu Asn Val Asp Asn Lys 
                165                 170                 175     


Lys Ser Lys Tyr Glu Glu Asp Pro Arg Phe His Tyr Lys Phe Asp Asp 
            180                 185                 190         


Glu Asn Gly Lys Leu Thr Asp Lys Gly Leu Ala Phe Phe Ile Cys Leu 
        195                 200                 205             


Phe Leu Glu Arg Lys Tyr Ala Met Leu Phe Leu Pro Gln Ile His Gly 
    210                 215                 220                 


Phe Lys Gln Ser Gly Gln Lys Gly Ile Asp Glu Gly Lys Arg Ala Thr 
225                 230                 235                 240 


Lys Lys Leu Phe Ser Ile Tyr Ser Val Gln Ile Pro Lys Leu Arg Ile 
                245                 250                 255     


Asp Ser Glu Ser Ser Lys Met Thr Leu Gly Ile Asp Met Leu Asn Glu 
            260                 265                 270         


Leu Lys Lys Cys Pro Asp Glu Leu Phe Asp Leu Leu Ser Lys Glu His 
        275                 280                 285             


Gln Asp Arg Phe Arg Val Ser Thr Asp Asp Lys Pro Lys Glu Lys Asp 
    290                 295                 300                 


Gly Gly Glu Asp Glu Asp Leu Val Leu Gln Lys Arg Tyr Gly Asn Arg 
305                 310                 315                 320 


Phe Pro Tyr Leu Ala Leu Ser Tyr Ile Asp Gln Gln Glu Leu Phe Gln 
                325                 330                 335     


Asn Val Arg Phe Gln Val Ser Leu Gly Thr Tyr Arg Tyr Glu Phe Tyr 
            340                 345                 350         


Gly Lys Gln Gly Val Asp Asn Ile Glu Arg Val Arg Ile Leu Gln Lys 
        355                 360                 365             


Lys Leu His Gly Phe Gly Arg Leu Asp Glu Ile Glu Lys Lys Arg Lys 
    370                 375                 380                 


Glu Gly Trp Lys Ala Leu Ile Arg Pro Phe Glu Lys Ile Glu Lys Asp 
385                 390                 395                 400 


Thr Ala Asp Gln Leu Pro Tyr Ile Thr Asp Ser Tyr Ala Arg Tyr Met 
                405                 410                 415     


Ile Ser Asn Asn Arg Val Gly Met Tyr Trp Asp Ile Lys Asp Ser Asn 
            420                 425                 430         


Glu Ala Gly Asp Tyr Leu Pro Lys Leu Thr Glu Glu Gly Ala Ile Asn 
        435                 440                 445             


Lys Ala Pro Thr Cys Trp Leu Ser Ile Tyr Glu Leu Pro Ala Leu Ile 
    450                 455                 460                 


Phe His Ser Leu Leu Asn Lys Asn Gly Asp Lys Asn Cys Thr Gln Asn 
465                 470                 475                 480 


Ile Ile Arg Glu Tyr Ala Arg Lys Tyr Ile Lys Phe Phe Lys Asp Ile 
                485                 490                 495     


Gln Asp Gly Glu Leu Lys Pro Ser Thr Lys Glu Asn Ile Ala Lys Asp 
            500                 505                 510         


Ile Lys Glu Gly Tyr Asn Ile Glu Phe Thr Gln Val Pro Lys Glu Leu 
        515                 520                 525             


Gln Asp Tyr Leu Thr Gly Lys Lys Val Asn Ile Asp Asp Arg Phe Glu 
    530                 535                 540                 


Lys Leu Ala Glu Glu Arg Ile Arg Gln Met Leu Glu Arg Gly Asn Arg 
545                 550                 555                 560 


Arg Ile Glu Arg Ile Lys Arg Asp Ile Thr Thr Ile Gln Asp Ile Lys 
                565                 570                 575     


Leu Asn Arg Val Gly Lys Lys Arg Phe Val Glu Ile Lys Ser Gly Val 
            580                 585                 590         


Leu Ala Asp Phe Leu Ala Glu Asp Leu Leu Leu Phe Gln Pro Thr Lys 
        595                 600                 605             


Asp Glu Gly Lys Asp Lys Leu Thr Gly Met Asn Phe Gln Val Leu Gln 
    610                 615                 620                 


Ala Thr Ile Ala Tyr Tyr Gly Arg Tyr Lys Ala Glu Met Lys Gln Ile 
625                 630                 635                 640 


Phe Lys Asn Cys Asn Leu Leu Asp Ser Ala Ile Ala His Pro Phe Leu 
                645                 650                 655     


Ala Lys Val Met Asn Lys Thr His Asn Asp Ile Val Asp Phe Tyr Thr 
            660                 665                 670         


Thr Tyr Leu Ile Glu Arg Gly Asn Tyr Leu Ser Asn Cys Leu Lys Lys 
        675                 680                 685             


Gln Asn Tyr Lys Asn Tyr His Phe Leu Tyr Pro Glu Arg Glu Lys Trp 
    690                 695                 700                 


Gln Gln Arg Asn Asn Asp Tyr Tyr Lys Lys Leu Ala Gly Lys His Leu 
705                 710                 715                 720 


Lys Leu Pro Ile Glu Leu Pro Arg Gly Leu Phe Asn Asp Ala Ile Lys 
                725                 730                 735     


Lys Phe Leu Glu Asn Asn Val Ser Met Gln Gln Ala Leu Glu Lys Gly 
            740                 745                 750         


Arg Cys Asn Thr Val Tyr Leu Ile Gln Asn Tyr Phe Glu Ala Val Arg 
        755                 760                 765             


Lys Asp Ser Trp Gln Gln Phe Tyr Asp Phe Lys Arg Cys Tyr Lys Cys 
    770                 775                 780                 


Phe Asp Leu Leu His Gly Ile Lys Lys Gly Asn Lys Leu Gln Ser Val 
785                 790                 795                 800 


Tyr Phe Ser Thr Ala Glu Phe Ile Ala Lys Leu Lys Thr Phe Asp Ser 
                805                 810                 815     


Asp Val Asp Lys Tyr Thr Asn Ser Gln Tyr Asn Lys Glu Lys Glu Arg 
            820                 825                 830         


Leu Arg Asn Ala Gly Lys Tyr Arg Glu Leu Lys Thr Phe Glu Glu Glu 
        835                 840                 845             


Lys Glu Val Thr Ile Glu Lys Thr Lys Asn Lys Leu Thr Arg Leu Gln 
    850                 855                 860                 


Lys Asp Phe Glu Lys Asn Glu Lys Leu Leu Arg Leu Ser Lys Val Gln 
865                 870                 875                 880 


Asp Met Leu Leu Phe Trp Met Ala Lys Asn Ile Leu Val Asp Lys Val 
                885                 890                 895     


Leu Glu Leu Asp Glu Ile Glu Lys Tyr Lys Leu Lys Asp Ile Met Pro 
            900                 905                 910         


Asp Ser Glu Lys Asp Ile Leu Ser Lys Gln Thr Ser Phe Ser Ile Thr 
        915                 920                 925             


Leu Asn Leu Lys Asp Gly Ile Lys Lys Thr Ile Arg Gln Lys Gln Ile 
    930                 935                 940                 


Lys Leu Lys Asn Phe Gly Asn Phe Phe Arg Phe Val Arg Asp Arg Arg 
945                 950                 955                 960 


Ile Ala Ser Leu Leu Pro His Ile Ala Ala Asp Glu Ile Asp Arg Asp 
                965                 970                 975     


Thr Leu Glu Lys Glu Leu Glu Asn Tyr Asp Asp His Arg Lys Glu Ile 
            980                 985                 990         


Phe Arg Phe Ile His Gln Phe Glu  Glu Lys Val Ile Lys  Asp Lys Ser 
        995                 1000                 1005             


Leu Gln  Glu Thr Ser Pro Asn  Phe Ile Lys Ile Leu  Glu His Cys 
    1010                 1015                 1020             


Pro Glu  Met Lys Gly Ile Asn  Lys Lys Gln Met Arg  Leu Met Arg 
    1025                 1030                 1035             


Asn Ala  Phe Cys His Asn Thr  Tyr Pro Ser Val Lys  Asp Leu Arg 
    1040                 1045                 1050             


Gln Lys  Glu Glu Lys Ala Asp  Glu Glu Met Ile Gln  Ala Glu Ser 
    1055                 1060                 1065             


Leu Leu  Tyr Glu Gly Ala Ser  Ile Pro Asp Ile Ala  Asn Arg Met 
    1070                 1075                 1080             


Lys Glu  Ile Phe Glu Gly Leu  Ile Thr Asn 
    1085                 1090             


<210>  1623
<211>  1136
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1623

Met Glu Thr Val Asn Glu Asn Lys Lys Arg Thr Pro Glu Asp Asp Ser 
1               5                   10                  15      


Gln Tyr Phe Gly Ala Tyr Leu Asn Leu Ala Arg Leu Asn Ile Tyr Ala 
            20                  25                  30          


Ile Asn Asn His Leu Ala Lys Glu Phe Lys Arg Ala Gly Leu Glu Glu 
        35                  40                  45              


Asp Gly Tyr Ile Lys Asn Ser Phe Ile Cys Asn Asp Asn Ile Lys His 
    50                  55                  60                  


Leu Asn Tyr Asn Tyr Leu Phe Glu Lys Leu Val Arg Leu Met Pro Val 
65                  70                  75                  80  


Val Lys Gln Phe Asp Ala Ala Arg Leu Pro Glu Lys Glu Arg Glu Lys 
                85                  90                  95      


Ala Glu Ala Glu Gly Lys Ser Leu Val Glu Met Ala Lys Thr Leu Arg 
            100                 105                 110         


Ala Val Phe Asp Asp Ile Gln Gln Phe Arg Asn Asp Tyr Thr His Tyr 
        115                 120                 125             


Tyr Ser Val Glu Trp Gly Asp Ile Arg Lys Val Val Ile Ser Glu Glu 
    130                 135                 140                 


Thr Ala Gly Phe Leu Lys Lys Ser Phe Glu Arg Ala Val Glu Tyr Thr 
145                 150                 155                 160 


Lys Val Arg Phe Ala Gly Val Leu Asp Glu Ser Asp Phe Lys Ala Val 
                165                 170                 175     


Glu Lys Lys Ser Leu Val Thr Lys Ser Asn Thr Gly Lys Asn Arg Ile 
            180                 185                 190         


Thr Thr Glu Gly Leu Val Phe Leu Thr Ser Met Phe Leu Asp Arg Glu 
        195                 200                 205             


Asn Ala Phe Leu Phe Ile Gly Lys Val Lys Gly Leu Lys Asp Thr Arg 
    210                 215                 220                 


Tyr Lys Pro Phe Ile Ala Met Arg Glu Ala Leu Met Ala Tyr Cys Val 
225                 230                 235                 240 


Lys Leu Pro His Asp Lys Leu Ile Ser Asp Asp Pro Lys Lys Ala Leu 
                245                 250                 255     


Phe Leu Asp Met Leu Asn Glu Leu Asn Arg Cys Pro Lys Gln Leu Tyr 
            260                 265                 270         


Asn Val Leu Asp Glu Asp Ala Lys Lys Glu Phe Arg Pro Ala Leu Ser 
        275                 280                 285             


Asp Glu Ser Leu Lys Asn Val Phe Glu Asn Ser Val Asp Glu Glu Ala 
    290                 295                 300                 


Leu Asp Glu Leu Gly Tyr Gln Lys Tyr Ile Glu Leu Leu Thr Met Arg 
305                 310                 315                 320 


Val Arg His Asp Asn Arg Phe Tyr Tyr His Thr Met Arg Phe Ile Asp 
                325                 330                 335     


Glu Gln Asn Leu Leu Pro Asp Phe Tyr Phe Gln Ile Asp Leu Gly Lys 
            340                 345                 350         


Tyr Ile Leu Ala Asp Tyr Gln Lys Thr Ile Leu Gly Glu Glu Thr Pro 
        355                 360                 365             


Arg Ile Ile Met Glu Asn Ala Lys Ala Phe Gly Arg Leu Gly Ser Phe 
    370                 375                 380                 


Thr Ser Pro Asp Glu Val Gly Lys Gln Ile Asp Ser Asn Gly Leu Gly 
385                 390                 395                 400 


Lys Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp Phe Asn Lys 
                405                 410                 415     


Ile Gly Ile Ala Phe Lys Arg Asp Leu Pro Ile Val Leu Lys Lys Glu 
            420                 425                 430         


Gly Ser His Ile Pro Cys Asn Leu Lys Gln Pro His Pro Glu Ala Phe 
        435                 440                 445             


Leu Ser Leu His Glu Leu Ser Lys Ile Val Leu Leu Glu Cys Leu Glu 
    450                 455                 460                 


Lys Gly Glu Ser Leu Gln Leu Ile Lys Glu His Leu Gly Thr Ala Asp 
465                 470                 475                 480 


Asp Lys Leu Phe Asn Ile Glu Phe Ile Glu Gln Ile Lys Ser Glu Leu 
                485                 490                 495     


Pro Glu Trp Glu Val Phe Arg Lys Gln Cys Asp Thr Lys Lys Ala Lys 
            500                 505                 510         


Ala Tyr Ser Ser Arg Lys Thr Pro Ser Tyr Pro Lys Glu Arg Lys Glu 
        515                 520                 525             


Lys Leu Asp Glu Val Leu Lys Pro His Gly Leu Asn Arg Lys Arg Ile 
    530                 535                 540                 


Pro Glu Arg Ile Leu Asn Tyr Trp Leu Asn Ile Glu Asp Val Gly Ala 
545                 550                 555                 560 


Glu Arg Ser Ile Thr Glu Arg Ile Leu Leu Met Lys Arg Asp Gly Leu 
                565                 570                 575     


Lys Arg Leu Lys Gln Leu Glu Lys His Arg Ser Asn Pro Glu Val Gly 
            580                 585                 590         


Ile Pro Lys Val Gly Glu Met Ala Thr Phe Ile Ala Arg Asp Ile Val 
        595                 600                 605             


Gly Met Ile Ile Asp Lys Glu Arg Lys Asn Lys Ile Thr Pro Ile Tyr 
    610                 615                 620                 


Tyr Asp Met Met Gln Gly Cys Leu Ala Tyr Tyr Ala Asp Arg Glu Lys 
625                 630                 635                 640 


Lys Arg Arg Phe Ile Gly Leu Val Lys Glu Leu Lys Leu Asn Glu Ser 
                645                 650                 655     


Asp Gly His Pro Phe Leu Lys Asn Leu Asp Phe Glu Lys Ile His Lys 
            660                 665                 670         


Thr Ser Glu Phe Tyr Lys Leu Tyr Leu Glu Glu Lys Val Tyr Lys Gln 
        675                 680                 685             


Glu Lys Phe Phe Asn Tyr Arg Lys Asn Lys Glu Gln Thr Lys Glu Val 
    690                 695                 700                 


Ser Trp Val Thr Lys Thr Phe Glu Lys Lys Lys Arg Asn Glu Lys Ala 
705                 710                 715                 720 


Glu Arg Leu Asp Thr Thr Phe Glu Leu Pro Glu Asp Lys Ser Ser Leu 
                725                 730                 735     


Pro Tyr Ser Ile Arg Gln Trp Glu Glu Lys Glu Glu Tyr Asp Leu Arg 
            740                 745                 750         


Ala Trp Leu Arg Asn Ile Lys Lys Gly Arg Gln Ser Gly Asp Arg Lys 
        755                 760                 765             


Arg Pro Ile Asp Leu Pro Thr Asp Leu Phe Asp Glu Arg Leu Arg Lys 
    770                 775                 780                 


Leu Leu Ser Glu Arg Leu Glu Glu Gln Gly Gln Thr Val Lys Glu Gly 
785                 790                 795                 800 


Ala Lys Tyr Lys Glu Leu Phe Lys Cys Trp Trp Glu Thr Lys Arg Gly 
                805                 810                 815     


Asp Asn Val Gln Ser Phe Tyr Asn Gly Thr Arg Cys Tyr Thr Ile Lys 
            820                 825                 830         


Gly Glu Gln Val Ser Phe Glu Pro Asp Ser Glu Ser Ser Phe Val Ser 
        835                 840                 845             


Tyr Tyr Arg Thr Pro Leu Asn Lys Ala Tyr Lys Arg Leu His Ala Gln 
    850                 855                 860                 


Arg Glu Glu Glu Arg Glu Lys Asn Lys Lys Leu Pro Ser Leu Arg Glu 
865                 870                 875                 880 


Pro Asp Met Glu Lys Val Phe Lys Arg Thr Leu Ser Glu Thr Glu Arg 
                885                 890                 895     


Asp Ile Arg Met Leu Ala Tyr Gln Asp Cys Val Leu Leu Leu Met Ala 
            900                 905                 910         


Glu Gln Leu Gly Ser Gly Glu Glu Thr Glu His Leu Lys Leu Ser Gly 
        915                 920                 925             


Ile Asn Lys Glu Leu Asn Lys Ile Ser Asp Val Lys Arg Glu Phe Ser 
    930                 935                 940                 


Tyr Thr Pro Tyr Tyr Asp Glu Leu Gly Lys Val Pro Pro Lys Gly Ala 
945                 950                 955                 960 


Glu Leu Pro Ala Val Arg Leu Thr Val Thr Ala Lys Met Lys Leu Lys 
                965                 970                 975     


Asn Ile Lys Asp Leu Asn Arg Phe Ala Tyr Asp Arg Arg Ile Pro Glu 
            980                 985                 990         


Leu Val Ala Tyr Leu Pro Gly Ala  Ala Ile Asp Ala Asp  Ser Leu Arg 
        995                 1000                 1005             


His Glu  Leu Thr Asp Tyr Asn  Lys Ala Arg Gln Thr  Val Phe Asp 
    1010                 1015                 1020             


Thr Val  Phe Arg Leu Glu Lys  Glu Ile Val Lys Lys  Asp His Glu 
    1025                 1030                 1035             


Gly Leu  Ile Lys Leu Asn Val  Asp Asp Lys Gly Pro  Leu Pro Gly 
    1040                 1045                 1050             


Asn Ile  Gln His Arg Pro Tyr  Met Gln Trp Leu Ile  Asn Glu Glu 
    1055                 1060                 1065             


Ile Ile  Ser Glu Asp Glu Arg  Phe Arg Leu Asn Met  Ile Arg Asn 
    1070                 1075                 1080             


Cys Phe  Ser His Asn Gln Phe  Pro His Glu Val Ala  Ile Arg Asn 
    1085                 1090                 1095             


Lys Asp  Ser Met Ala Leu Pro  Gly Ile Ala Ser Lys  Ile Ala Glu 
    1100                 1105                 1110             


Gln Tyr  Glu Gln Arg Ile Ala  Glu Ile Ile Glu Glu  Ile Asn Lys 
    1115                 1120                 1125             


Lys Gly  Gly His Asn Pro Asp  Cys 
    1130                 1135     


<210>  1624
<211>  1125
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1624

Met Glu Asp Asp Lys Lys Thr Thr Glu Ser Thr Asn Met Leu Asp Asn 
1               5                   10                  15      


Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val Tyr 
            20                  25                  30          


Ile Thr Val Asn His Ile Asn Lys Val Leu Glu Leu Lys Asn Lys Lys 
        35                  40                  45              


Asp Gln Asp Ile Ile Ile Asp Asn Asp Gln Asp Ile Leu Ala Ile Lys 
    50                  55                  60                  


Thr His Trp Glu Lys Val Asp Gly Asp Leu Asn Lys Thr Glu Arg Leu 
65                  70                  75                  80  


Arg Glu Leu Met Thr Lys His Phe Pro Phe Leu Glu Thr Ala Ile Tyr 
                85                  90                  95      


Thr Lys Asn Lys Glu Asp Lys Glu Glu Val Lys Gln Glu Lys Gln Ala 
            100                 105                 110         


Lys Ala Gln Ser Phe Asp Ser Leu Lys His Cys Leu Phe Leu Phe Leu 
        115                 120                 125             


Glu Lys Leu Gln Glu Ala Arg Asn Tyr Tyr Ser His Tyr Lys Tyr Ser 
    130                 135                 140                 


Glu Ser Thr Lys Glu Pro Met Leu Glu Lys Glu Leu Leu Lys Lys Met 
145                 150                 155                 160 


Tyr Asn Ile Phe Asp Asp Asn Ile Gln Leu Val Ile Lys Asp Tyr Gln 
                165                 170                 175     


His Asn Lys Asp Ile Asn Pro Asp Glu Asp Phe Lys His Leu Asp Arg 
            180                 185                 190         


Thr Glu Glu Asp Phe Asn Tyr Tyr Phe Thr Arg Asn Lys Lys Gly Asn 
        195                 200                 205             


Ile Thr Ala Ser Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys 
    210                 215                 220                 


Lys Asp Ala Ile Trp Met Gln Gln Lys Leu Arg Gly Phe Lys Asp Asn 
225                 230                 235                 240 


Arg Glu Ser Lys Lys Lys Met Thr His Glu Val Phe Cys Arg Arg Arg 
                245                 250                 255     


Met Leu Leu Pro Lys Leu Arg Leu Glu Ser Thr Gln Thr Gln Asp Trp 
            260                 265                 270         


Ile Leu Leu Asp Met Leu Asn Glu Leu Ile Arg Cys Pro Lys Ser Leu 
        275                 280                 285             


Tyr Glu Arg Leu Gln Gly Glu Asp Arg Glu Lys Phe Lys Val Pro Phe 
    290                 295                 300                 


Asp Pro Ala Asp Glu Asp Tyr Asp Ala Glu Gln Glu Pro Phe Lys Asn 
305                 310                 315                 320 


Thr Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr 
                325                 330                 335     


Phe Asp Tyr Asn Glu Ile Phe Thr Asn Leu Arg Phe Gln Ile Asp Leu 
            340                 345                 350         


Gly Thr Tyr His Phe Ser Ile Tyr Lys Lys Leu Ile Gly Gly Gln Lys 
        355                 360                 365             


Glu Asp Arg His Leu Thr His Lys Leu Tyr Gly Phe Glu Arg Ile Gln 
    370                 375                 380                 


Glu Phe Ala Lys Gln Asn Arg Pro Asp Glu Trp Lys Ala Ile Val Lys 
385                 390                 395                 400 


Asp Leu Asp Thr Tyr Glu Thr Ser Asn Glu Arg Tyr Ile Ser Glu Thr 
                405                 410                 415     


Thr Pro His Tyr His Leu Glu Asn Gln Lys Ile Gly Ile Arg Phe Arg 
            420                 425                 430         


Asn Gly Asn Asn Asp Ile Trp Pro Ser Leu Glu Thr Asn Gly Glu Asn 
        435                 440                 445             


Asn Glu Lys Ser Lys Tyr Lys Leu Asp Lys Gln Tyr Gln Ala Glu Ala 
    450                 455                 460                 


Phe Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu 
465                 470                 475                 480 


Leu Lys Lys Glu Glu Pro Asn Asn Asp Lys Lys Asn Ala Ser Ile Val 
                485                 490                 495     


Glu Gly Phe Ile Lys Arg Glu Ile Arg Asp Ile Tyr Lys Leu Tyr Asp 
            500                 505                 510         


Ala Phe Ala Asn Gly Glu Ile Asn Asn Ile Asp Asp Leu Glu Lys Tyr 
        515                 520                 525             


Cys Glu Asp Lys Gly Ile Pro Lys Arg His Leu Pro Lys Gln Met Val 
    530                 535                 540                 


Ala Ile Leu Tyr Asp Glu Pro Lys Asp Met Val Lys Glu Ala Lys Arg 
545                 550                 555                 560 


Lys Gln Lys Glu Met Val Lys Asp Thr Lys Lys Leu Leu Ala Thr Leu 
                565                 570                 575     


Glu Lys Gln Thr Gln Gly Glu Ile Glu Asp Gly Gly Arg Asn Ile Arg 
            580                 585                 590         


Leu Leu Lys Ser Gly Glu Ile Ala Arg Trp Leu Val Asn Asp Met Met 
        595                 600                 605             


Arg Phe Gln Pro Val Gln Lys Asp Asn Glu Gly Asn Pro Leu Asn Asn 
    610                 615                 620                 


Ser Lys Ala Asn Ser Thr Glu Tyr Gln Met Leu Gln Arg Ser Leu Ala 
625                 630                 635                 640 


Leu Tyr Asn Lys Glu Glu Lys Pro Thr Arg Tyr Phe Arg Gln Val Asn 
                645                 650                 655     


Leu Ile Asn Ser Ser Asn Pro His Pro Phe Leu Lys Trp Thr Lys Trp 
            660                 665                 670         


Glu Glu Cys Asn Asn Ile Leu Ser Phe Tyr Arg Ser Tyr Leu Thr Lys 
        675                 680                 685             


Lys Ile Glu Phe Leu Asn Lys Leu Lys Pro Glu Asp Trp Glu Lys Asn 
    690                 695                 700                 


Gln Tyr Phe Leu Lys Leu Lys Glu Pro Lys Thr Asn Arg Lys Thr Leu 
705                 710                 715                 720 


Val Gln Gly Trp Lys Asn Gly Phe Asn Leu Pro Arg Gly Ile Phe Thr 
                725                 730                 735     


Glu Pro Ile Arg Glu Trp Phe Lys Arg His Gln Asn Asp Ser Lys Glu 
            740                 745                 750         


Tyr Glu Lys Val Glu Ala Leu Lys Arg Val Gly Leu Val Thr Lys Val 
        755                 760                 765             


Ile Pro Leu Phe Phe Lys Glu Glu Tyr Phe Lys Glu Asp Ala Gln Lys 
    770                 775                 780                 


Glu Met Asn Asn Cys Val Gln Pro Phe Tyr Gly Phe Pro Tyr Asn Val 
785                 790                 795                 800 


Gly Asn Ile His Lys Pro Lys Glu Glu Asp Phe Leu His Arg Glu Glu 
                805                 810                 815     


Arg Arg Lys Leu Trp Asp Lys Lys Lys Asp Lys Phe Lys Gly Tyr Lys 
            820                 825                 830         


Ala Lys Val Lys Ser Lys Lys Leu Thr Asp Lys Glu Lys Glu Glu Tyr 
        835                 840                 845             


Arg Ser Tyr Leu Glu Phe Gln Ser Trp Asn Lys Phe Glu Arg Glu Leu 
    850                 855                 860                 


Arg Leu Val Arg Asn Gln Asp Ile Val Thr Trp Leu Leu Cys Thr Glu 
865                 870                 875                 880 


Leu Ile Asp Lys Met Lys Val Glu Gly Leu Asn Val Glu Glu Leu Gln 
                885                 890                 895     


Lys Leu Arg Leu Lys Asp Ile Asp Thr Asp Thr Ala Lys Gln Glu Lys 
            900                 905                 910         


Asn Asn Ile Leu Asn Arg Ile Met Pro Met Gln Leu Pro Val Thr Val 
        915                 920                 925             


Tyr Glu Ile Asp Asp Ser His Asn Ile Val Lys Asp Arg Pro Leu His 
    930                 935                 940                 


Thr Val Tyr Ile Glu Glu Thr Lys Thr Lys Leu Leu Lys Gln Gly Asn 
945                 950                 955                 960 


Phe Lys Ala Leu Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe 
                965                 970                 975     


Val Asp Thr Ser Ser Glu Ala Asp Leu Lys Asp Lys Pro Ile Ser Lys 
            980                 985                 990         


Ser Val Val Glu Tyr Glu Leu Gly  Glu Tyr Gln Asn Ala  Arg Ile Glu 
        995                 1000                 1005             


Thr Ile  Lys Asp Met Leu Leu  Leu Glu Glu Thr Leu  Ile Lys Lys 
    1010                 1015                 1020             


Tyr Lys  Thr Leu Pro Thr Asn  Lys Phe Ser Ala Met  Leu Asn Gly 
    1025                 1030                 1035             


Trp Leu  Glu Gly Lys Asp Glu  Ala Asp Lys Ala Arg  Phe Gln Asn 
    1040                 1045                 1050             


Asp Val  Lys Leu Leu Val Ala  Val Arg Asn Ala Phe  Ser His Asn 
    1055                 1060                 1065             


Gln Tyr  Pro Met Arg Asn Arg  Ile Ala Phe Ala Asn  Ile Asn Pro 
    1070                 1075                 1080             


Phe Ser  Leu Ser Ser Ala Asp  Thr Ser Glu Glu Lys  Lys Leu Asp 
    1085                 1090                 1095             


Ile Ala  Asn Gln Leu Lys Asp  Lys Thr Lys Glu Thr  Ile Glu Lys 
    1100                 1105                 1110             


Ile Ile  Glu Ile Glu Lys Pro  Ile Glu Thr Lys Glu  
    1115                 1120                 1125 


<210>  1625
<211>  1174
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1625

Met Thr Glu Gln Asn Glu Arg Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Phe Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Ala His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Met Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Lys Tyr Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Glu Lys Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Ala Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Gly Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Leu Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Glu Glu Val 
            500                 505                 510         


Ser Ala Glu Lys Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Asp Glu Ile Asn Thr Arg Asp 
    530                 535                 540                 


Glu Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Ile Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Ser His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Ser Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Tyr Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Asp Leu Glu Ala Trp Ser His Ser Ala Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Val Gly Ile Glu Tyr Ala Ser Trp Glu Asn 
    850                 855                 860                 


Lys Thr Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Lys Ala 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Lys Ala Asp Lys Ile Asn Ile Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Ala Lys Glu His Pro Tyr His Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asp Ile Arg Thr 
945                 950                 955                 960 


Asp Val Gln Glu Gln Gly Ser Leu Asn Val Leu Asn Arg Val Lys Pro 
                965                 970                 975     


Met Arg Leu Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val 
            980                 985                 990         


His Lys Glu Ala Pro Leu Ala Thr  Val Tyr Ile Glu Glu  Arg Asp Thr 
        995                 1000                 1005             


Lys Leu  Leu Lys Gln Gly Asn  Phe Lys Ser Phe Val  Lys Asp Arg 
    1010                 1015                 1020             


Arg Leu  Asn Gly Leu Phe Ser  Phe Val Asp Thr Gly  Gly Leu Ala 
    1025                 1030                 1035             


Met Glu  Gln Tyr Pro Ile Ser  Lys Leu Arg Val Glu  Tyr Glu Leu 
    1040                 1045                 1050             


Ala Lys  Tyr Gln Thr Ala Arg  Val Cys Ala Phe Glu  Gln Thr Leu 
    1055                 1060                 1065             


Glu Leu  Glu Glu Ser Leu Leu  Thr Arg Cys Pro His  Leu Pro Asp 
    1070                 1075                 1080             


Lys Asn  Phe Arg Lys Met Leu  Glu Ser Trp Ser Asp  Pro Leu Leu 
    1085                 1090                 1095             


Asp Lys  Trp Pro Asp Leu His  Arg Lys Val Arg Leu  Leu Ile Ala 
    1100                 1105                 1110             


Val Arg  Asn Ala Phe Ser His  Asn Gln Tyr Pro Met  Tyr Asp Glu 
    1115                 1120                 1125             


Ala Val  Phe Ser Ser Ile Arg  Lys Tyr Asp Pro Ser  Ser Leu Asp 
    1130                 1135                 1140             


Ala Ile  Glu Glu Arg Met Gly  Leu Asn Ile Ala His  Arg Leu Ser 
    1145                 1150                 1155             


Glu Glu  Val Lys Gln Ala Lys  Glu Met Ala Glu Arg  Ile Ile Gln 
    1160                 1165                 1170             


Val 
    


<210>  1626
<211>  1175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1626

Met Thr Glu Gln Asn Glu Arg Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Phe Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Ala His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Met Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Lys Tyr Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Glu Lys Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Ala Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Gly Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Leu Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Glu Glu Val 
            500                 505                 510         


Ser Ala Glu Lys Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Asp Glu Ile Asn Thr Arg Asp 
    530                 535                 540                 


Glu Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Ile Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Ser His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Ser Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Tyr Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Asp Leu Glu Ala Trp Ser His Ser Ala Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Val Gly Ile Glu Tyr Ala Ser Trp Glu Asn 
    850                 855                 860                 


Lys Thr Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Lys Ala 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Lys Ala Asp Lys Ile Asn Ile Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Ala Lys Glu His Pro Tyr His Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asp Ile Arg Thr 
945                 950                 955                 960 


Asp Val Gln Glu Gln Gly Ser Leu Asn Val Leu Asn Arg Val Lys Pro 
                965                 970                 975     


Met Arg Leu Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val 
            980                 985                 990         


His Lys Glu Glu Ala Pro Leu Ala  Thr Val Tyr Ile Glu  Glu Arg Asp 
        995                 1000                 1005             


Thr Lys  Leu Leu Lys Gln Gly  Asn Phe Lys Ser Phe  Val Lys Asp 
    1010                 1015                 1020             


Arg Arg  Leu Asn Gly Leu Phe  Ser Phe Val Asp Thr  Gly Gly Leu 
    1025                 1030                 1035             


Ala Met  Glu Gln Tyr Pro Ile  Ser Lys Leu Arg Val  Glu Tyr Glu 
    1040                 1045                 1050             


Leu Ala  Lys Tyr Gln Thr Ala  Arg Val Cys Ala Phe  Glu Gln Thr 
    1055                 1060                 1065             


Leu Glu  Leu Glu Glu Ser Leu  Leu Thr Arg Cys Pro  His Leu Pro 
    1070                 1075                 1080             


Asp Lys  Asn Phe Arg Lys Met  Leu Glu Ser Trp Ser  Asp Pro Leu 
    1085                 1090                 1095             


Leu Asp  Lys Trp Pro Asp Leu  His Arg Lys Val Arg  Leu Leu Ile 
    1100                 1105                 1110             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1115                 1120                 1125             


Glu Ala  Val Phe Ser Ser Ile  Arg Lys Tyr Asp Pro  Ser Ser Leu 
    1130                 1135                 1140             


Asp Ala  Ile Glu Glu Arg Met  Gly Leu Asn Ile Ala  His Arg Leu 
    1145                 1150                 1155             


Ser Glu  Glu Val Lys Gln Ala  Lys Glu Met Ala Glu  Arg Ile Ile 
    1160                 1165                 1170             


Gln Val  
    1175 


<210>  1627
<211>  1231
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1627

Met Glu Asn Asn Pro Ser Asn Ile Phe Ser Lys Pro Thr Val Ser Pro 
1               5                   10                  15      


Lys Thr Arg Arg Ser Glu Gly Cys Glu Lys Pro Asp Ser His Ser Ala 
            20                  25                  30          


Glu Leu Arg Pro Val Tyr Ala Ala Tyr Leu Asn Met Ala Gln Met Asn 
        35                  40                  45              


Leu Phe Asn Thr Leu Lys Ala Ile Glu Gly Lys Leu Gly Ile Val Thr 
    50                  55                  60                  


Pro Asp Ala Lys Glu Asp Tyr Met Glu Gly Met Lys Ile Val Gly Phe 
65                  70                  75                  80  


Asp Lys Asp Lys Asn Ile Lys Glu Val Glu Val Arg Val Lys Ala Phe 
                85                  90                  95      


Lys Glu Leu Leu Lys Arg Ile Pro Val Leu Gln Ser Leu Ser Gly Tyr 
            100                 105                 110         


Gln Ile Lys Asp Asp Val Lys Thr Val Ser Phe Glu Asp Val Ala Glu 
        115                 120                 125             


Leu Leu Leu Ala Ile Val Lys Ile Val His Tyr Tyr Arg Asn Glu Tyr 
    130                 135                 140                 


Ser His Thr His His Tyr Tyr Thr Asp Ala Glu Lys Ala Glu Glu Ala 
145                 150                 155                 160 


Asp Phe Glu Lys Arg Ile Met Gln Pro Leu Asp Leu Ala Phe Lys Ser 
                165                 170                 175     


Ala Lys Arg Asn Met Ala Lys Val His Gly Tyr Gly Lys Lys Glu Leu 
            180                 185                 190         


Asp Phe Ile Asp Gly Asn Glu Arg Gln Glu Val Thr Gly Lys Gly Arg 
        195                 200                 205             


Asp Lys Lys Val Lys Tyr Tyr Thr Asp Tyr Tyr Phe Arg Leu Gly Asn 
    210                 215                 220                 


Asp Asp Phe Thr Arg Leu Ser Asp Val Gly Ile Ala Phe Ile Val Cys 
225                 230                 235                 240 


Lys Leu Leu Asn Lys Lys Tyr Ala Ile Gln Phe Leu Gln Gln Ser Lys 
                245                 250                 255     


Ile Met Thr Pro Arg Ser Gln Gly Gly Leu Ser Pro Phe Ser Gln Glu 
            260                 265                 270         


Glu Asn Glu Val Met Ala Asn Ile Phe Cys Ala Glu Arg Ile Arg Leu 
        275                 280                 285             


Pro Lys Gly Arg Met Glu Val Glu Ser Leu Asp Arg Lys Ala Ala Leu 
    290                 295                 300                 


Gly Leu Asp Met Leu Asn Glu Leu Gln Lys Cys Pro Lys Glu Leu Phe 
305                 310                 315                 320 


Asp Thr Phe Cys Gln Asp Asp Lys Glu Leu Phe Lys Val Val Gln Asp 
                325                 330                 335     


Glu Glu Glu Gln Gln Ser Asp Leu Glu Asp Gly Ala Leu Met Arg Arg 
            340                 345                 350         


Asn Asp Asp Arg Phe Pro Val Leu Ala Leu Arg Tyr Ile Asp Glu Gln 
        355                 360                 365             


Lys Val Leu Asn Gly Met Ala Phe Gln Val Ser Leu Gly Asn Tyr Arg 
    370                 375                 380                 


Tyr Gln Phe Tyr Asn Lys Thr Thr Ile Asp Pro Ser Asp Pro Asn Arg 
385                 390                 395                 400 


Val Arg Ile Leu Gln Lys Glu Ile Asn Gly Phe Gly Pro Met His Leu 
                405                 410                 415     


Val Glu Ser Lys Phe Lys Glu Lys Tyr Gly Lys Asp Gly Phe Asn Leu 
            420                 425                 430         


Ile Arg Glu Ser Gln Ser Glu Ala Pro Ala Asp Thr Ala Ser Thr Lys 
        435                 440                 445             


Pro Tyr Leu Thr Asp Lys Arg Ala Ser Tyr Val Ile His Asn Asn Arg 
    450                 455                 460                 


Val Cys Ile Met Leu Lys Glu Lys Gly Ser Pro Leu Asp Lys Asp Cys 
465                 470                 475                 480 


Cys Tyr Leu Pro Asp Leu Pro Val Pro Lys Glu Glu Asn Gly Thr Gln 
                485                 490                 495     


Lys Val Asn Arg Ser Gly Asp Glu Lys Glu Lys Asp Trp Pro His Thr 
            500                 505                 510         


Cys Trp Leu Ser Ile Tyr Asp Leu Pro Ala Leu Val Phe Leu His Leu 
        515                 520                 525             


Leu Gly Gly Asn Pro Gly Gln Val Ile Arg Asp Tyr Val Gly Lys Ile 
    530                 535                 540                 


Arg Ser Leu Leu Asn Asp Ile Ala Glu Glu Lys Cys Val Pro Pro Cys 
545                 550                 555                 560 


Cys Asp Glu Leu Ser Pro Thr Asp Gly Ser Gln Arg Lys Lys Thr Ile 
                565                 570                 575     


Thr Lys Pro Lys Glu Val Val Asp Ile Trp Leu Lys Glu Gln Tyr Asn 
            580                 585                 590         


Leu Pro Leu Ser Ser Val Pro Glu Lys Ile Val Asp Tyr Leu Ala Gly 
        595                 600                 605             


Val Ser Gly Gly Ser Met Glu Glu Glu Arg His Lys Ala Glu Asp Gly 
    610                 615                 620                 


Phe Ser Lys Trp Ala Lys Ser Ala Val Glu Lys Glu Ile Gly Asp Thr 
625                 630                 635                 640 


Glu Leu Arg Gln Lys Arg Phe Gln Asn Asp Lys Lys Arg Val Gly Ser 
                645                 650                 655     


Lys Ala Asn Arg Ile Gly Lys Lys Ser Tyr Val Glu Ile Arg Pro Gly 
            660                 665                 670         


Arg Leu Ala Asp Phe Leu Ala Lys Asp Ile Met Lys Met Gln Pro Ala 
        675                 680                 685             


Asp Ala Glu Lys Asn His Cys Gly Lys Leu Thr Gly Gln Asn Tyr Gln 
    690                 695                 700                 


Ile Met Gln Ala Ala Ile Ala Thr Phe Lys Gly Asp Gly Arg Glu Cys 
705                 710                 715                 720 


Arg Leu Thr Gly Leu Gly Glu Leu Phe Val Lys Ala Gly Leu Val Gly 
                725                 730                 735     


Lys Asp Asn Gln Gln Lys His Pro Phe Leu Asp Lys Val Leu Thr Asn 
            740                 745                 750         


Glu Ile Thr Asp Thr Leu Asp Phe Tyr Glu Lys Tyr Leu Glu Glu Lys 
        755                 760                 765             


Lys Tyr Tyr Leu Glu Gln Leu Leu Cys Ser Glu Lys Tyr Ser Glu Ala 
    770                 775                 780                 


Tyr Phe Leu His Gly Gly Leu Asn Asp Tyr Lys Pro Lys Asp Arg Asp 
785                 790                 795                 800 


Tyr Ile Lys Leu Leu Ala Gly Arg Tyr Lys Asp Thr Phe Gln Leu Pro 
                805                 810                 815     


Asp Gly Leu Phe Ala Asp Ala Ile Ser Glu Cys Leu Lys Lys Glu Asp 
            820                 825                 830         


Asn Val Glu Ile Arg Asn Ala Ala Glu Gly Glu Asn Arg Asn Asn Ala 
        835                 840                 845             


Ala Tyr Leu Leu Arg Val Tyr Phe Thr Asn Lys Tyr Asp Asp Asp Ser 
    850                 855                 860                 


Gln Pro Phe Tyr Phe Gln Thr Asp Gly Arg Phe Lys Arg His Tyr Lys 
865                 870                 875                 880 


Val Phe Asp Thr Ile Glu Gly Lys Lys Asp Ala Thr Tyr Arg Thr Val 
                885                 890                 895     


Glu Glu Ile Arg Ala Met Leu Arg Lys Gly Ala Ala Asp Lys Ala Pro 
            900                 905                 910         


Val Arg Arg Ala Ile Ala Glu His Leu Asn Thr Met Gln Met Pro Gly 
        915                 920                 925             


Lys Pro Gln Trp Ile Asn Gly Lys Lys Lys Pro Ser Trp Arg Glu Ala 
    930                 935                 940                 


Thr Pro Asp Glu Lys Lys Ala Glu Ala Lys Lys Cys Gln Met Gln Leu 
945                 950                 955                 960 


Arg Tyr Cys Gln Gln Asn Glu Arg Ala Ile Arg Arg Tyr Lys Ala Glu 
                965                 970                 975     


Asp Met Leu Met Phe Met Met Ala Lys Arg Leu Leu Leu Glu Ser Asp 
            980                 985                 990         


Asn Val Leu Lys Lys Gly Asn Leu  Thr Gly Leu Glu Ala  Phe Lys Leu 
        995                 1000                 1005             


Arg Asp  Ile Lys Pro Ile Gly  Cys Lys Asn Gly Pro  Gln Asp Asn 
    1010                 1015                 1020             


Ile Leu  Asn Gln Gln Ile Asp  Phe Ser Ala Ala Ile  Asp Leu Phe 
    1025                 1030                 1035             


Val Glu  Glu Val Val His Tyr  Thr Asp Lys Lys Gly  Glu Glu Gly 
    1040                 1045                 1050             


Thr Arg  Phe Lys Thr Val Asn  Lys Asp Lys Lys Val  Ile Arg Gln 
    1055                 1060                 1065             


Ser Gly  Leu Lys Ile Lys Asn  Ile Gly Asp Phe Tyr  Arg Phe Ile 
    1070                 1075                 1080             


Phe Asp  Ser Arg Leu Gly Ser  Leu Leu Ser Gln Ile  Glu Gly Asp 
    1085                 1090                 1095             


Thr Phe  Glu Arg Glu Met Val  Glu Lys Glu Leu Asp  Thr Tyr Asp 
    1100                 1105                 1110             


Asn Arg  Arg Lys Asp Gly Phe  Lys Thr Ala His Glu  Ile Glu Arg 
    1115                 1120                 1125             


Val Ile  Ile Gly Lys Asn Lys  Glu Gln Ile Glu Thr  Arg Phe Lys 
    1130                 1135                 1140             


Asn Glu  Lys Ala Ala Gly Leu  Glu Ser Lys Lys Ile  Val Tyr Asn 
    1145                 1150                 1155             


Lys Phe  Gly Glu Leu Leu Lys  Tyr Cys Glu Leu Thr  Ser Asp Ile 
    1160                 1165                 1170             


Gln Ala  Lys Ile Val Asp Ile  Arg Asn Met Leu Ala  His Asn Lys 
    1175                 1180                 1185             


Tyr Met  Asp Asn Ile Glu Arg  Ile Val Asp Lys Asp  Asp Met Thr 
    1190                 1195                 1200             


Leu Pro  Gln Val Leu Glu Glu  Ile Ile Glu Trp Leu  Gln Asp Asn 
    1205                 1210                 1215             


Ser Lys  Lys Ile Thr His Thr  Asp Glu Ser Thr Asn  Thr 
    1220                 1225                 1230     


<210>  1628
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1628

Leu Gln Lys Gln Asp Lys Leu Phe Val Asp Arg Lys Lys Asn Ala Ile 
1               5                   10                  15      


Phe Ala Phe Pro Lys Tyr Ile Thr Ile Met Glu Asn Lys Glu Lys Pro 
            20                  25                  30          


Glu Pro Ile Tyr Tyr Glu Leu Thr Asp Lys His Phe Trp Ala Ala Phe 
        35                  40                  45              


Leu Asn Leu Ala Arg His Asn Val Tyr Thr Thr Ile Asn His Ile Asn 
    50                  55                  60                  


Arg Arg Leu Glu Ile Ala Glu Leu Lys Asp Asp Gly Tyr Met Met Gly 
65                  70                  75                  80  


Ile Lys Gly Ser Trp Asn Glu Gln Ala Lys Lys Leu Asp Lys Lys Val 
                85                  90                  95      


Arg Leu Arg Asp Leu Ile Met Lys His Phe Pro Phe Leu Glu Ala Ala 
            100                 105                 110         


Ala Tyr Glu Met Thr Asn Ser Lys Ser Pro Asn Asn Lys Glu Gln Arg 
        115                 120                 125             


Glu Lys Glu Gln Ser Glu Ala Leu Ser Leu Asn Asn Leu Lys Asn Val 
    130                 135                 140                 


Leu Phe Ile Phe Leu Glu Lys Leu Gln Val Leu Arg Asn Tyr Tyr Ser 
145                 150                 155                 160 


His Tyr Lys Tyr Ser Glu Glu Ser Pro Lys Pro Thr Phe Glu Thr Ser 
                165                 170                 175     


Leu Leu Lys Asn Met Tyr Lys Val Phe Asp Ala Asn Val Arg Leu Val 
            180                 185                 190         


Lys Arg Asp Tyr Met His His Glu Asn Ile Asp Met Gln Arg Asp Phe 
        195                 200                 205             


Thr His Leu Asn Arg Lys Lys Gln Val Gly Arg Thr Lys Asn Ile Ile 
    210                 215                 220                 


Asp Ser Pro Asn Phe His Tyr His Phe Ala Asp Lys Glu Gly Asn Met 
225                 230                 235                 240 


Thr Ile Ala Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Asp Lys Lys 
                245                 250                 255     


Asp Ala Ile Trp Met Gln Lys Lys Leu Lys Gly Phe Lys Asp Gly Arg 
            260                 265                 270         


Asn Leu Arg Glu Gln Met Thr Asn Glu Val Phe Cys Arg Ser Arg Ile 
        275                 280                 285             


Ser Leu Pro Lys Leu Lys Leu Glu Asn Val Gln Thr Lys Asp Trp Met 
    290                 295                 300                 


Gln Leu Asp Met Leu Asn Glu Leu Val Arg Cys Pro Lys Ser Leu Tyr 
305                 310                 315                 320 


Glu Arg Leu Arg Glu Lys Asp Arg Glu Ser Phe Lys Val Pro Phe Asp 
                325                 330                 335     


Ile Phe Ser Asp Asp Tyr Asp Ala Glu Glu Glu Pro Phe Lys Asn Thr 
            340                 345                 350         


Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe 
        355                 360                 365             


Asp Leu Asn Glu Ile Phe Glu Gln Leu Arg Phe Gln Ile Asp Leu Gly 
    370                 375                 380                 


Thr Tyr His Phe Ser Ile Tyr Asn Lys Arg Ile Gly Asp Glu Asp Glu 
385                 390                 395                 400 


Val Arg His Leu Thr His His Leu Tyr Gly Phe Ala Arg Ile Gln Asp 
                405                 410                 415     


Phe Ala Pro Gln Asn Gln Pro Glu Glu Trp Arg Lys Leu Val Lys Asp 
            420                 425                 430         


Leu Asp His Phe Glu Thr Ser Gln Lys Pro Tyr Ile Ser Lys Thr Ala 
        435                 440                 445             


Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Lys Phe Cys Ser 
    450                 455                 460                 


Thr His Asn Asn Leu Phe Pro Ser Leu Lys Arg Glu Lys Thr Cys Asn 
465                 470                 475                 480 


Gly Arg Ser Lys Phe Asn Leu Gly Thr Gln Phe Thr Ala Glu Ala Phe 
                485                 490                 495     


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu 
            500                 505                 510         


Thr Lys Asp Tyr Ser Arg Lys Glu Ser Ala Asp Lys Val Glu Gly Ile 
        515                 520                 525             


Ile Arg Lys Glu Ile Ser Asn Ile Tyr Ala Ile Tyr Asp Ala Phe Ala 
    530                 535                 540                 


Asn Gly Glu Ile Asn Ser Ile Ala Asp Leu Thr Cys Arg Leu Gln Lys 
545                 550                 555                 560 


Thr Asn Ile Leu Gln Gly His Leu Pro Lys Gln Met Ile Ser Ile Leu 
                565                 570                 575     


Glu Gly Arg Gln Lys Asp Met Glu Lys Glu Ala Glu His Lys Ile Gly 
            580                 585                 590         


Glu Met Ile Asp Asp Thr Gln Arg Arg Leu Asp Leu Leu Cys Lys Gln 
        595                 600                 605             


Thr Asn Gln Lys Ile Arg Ile Gly Lys Arg Asn Ala Gly Leu Leu Lys 
    610                 615                 620                 


Ser Gly Lys Ile Ala Asp Trp Leu Val Ser Asp Met Met Arg Phe Gln 
625                 630                 635                 640 


Pro Val Gln Lys Asp Thr Asn Asn Ala Pro Ile Asn Asn Ser Lys Ala 
                645                 650                 655     


Asn Ser Thr Glu Tyr Arg Met Leu Gln His Ala Leu Ala Leu Phe Gly 
            660                 665                 670         


Ser Glu Ser Ser Arg Leu Lys Ala Tyr Phe Arg Gln Met Asn Leu Val 
        675                 680                 685             


Gly Asn Ala Asn Pro His Pro Phe Leu Ala Glu Thr Gln Trp Glu His 
    690                 695                 700                 


Gln Thr Asn Ile Leu Ser Phe Tyr Arg Asn Tyr Leu Glu Ala Arg Lys 
705                 710                 715                 720 


Lys Tyr Leu Lys Gly Leu Lys Pro Gln Asn Trp Lys Gln Tyr Gln His 
                725                 730                 735     


Phe Leu Ile Leu Lys Val Gln Lys Thr Asn Arg Asn Thr Leu Val Thr 
            740                 745                 750         


Gly Trp Lys Asn Ser Phe Asn Leu Pro Arg Gly Ile Phe Thr Gln Pro 
        755                 760                 765             


Ile Arg Glu Trp Phe Glu Lys His Asn Asn Ser Lys Arg Ile Tyr Asp 
    770                 775                 780                 


Gln Ile Leu Ser Phe Gly Arg Val Gly Phe Val Ala Lys Ala Ile Pro 
785                 790                 795                 800 


Leu Tyr Phe Ala Glu Glu Cys Lys Asp Cys Val Gln Pro Phe Tyr Asp 
                805                 810                 815     


Tyr Pro Phe Asn Val Gly Asn Lys Leu Lys Pro Lys Lys Gly Gln Phe 
            820                 825                 830         


Leu Asp Lys Lys Asp Arg Val Glu Leu Trp Gln Lys Asn Lys Glu Leu 
        835                 840                 845             


Phe Lys Asn Tyr Pro Pro Glu Lys Arg Lys Thr Asp Leu Ala Tyr Leu 
    850                 855                 860                 


Asp Phe Leu Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys 
865                 870                 875                 880 


Asn Gln Asp Ile Val Thr Trp Leu Met Phe Lys Glu Leu Phe Lys Thr 
                885                 890                 895     


Thr Thr Val Glu Gly Leu Lys Ile Gly Glu Ile His Leu Arg Asp Ile 
            900                 905                 910         


Asp Thr Asn Thr Ala Asn Glu Glu Ser Asn Asn Ile Leu Asn Arg Ile 
        915                 920                 925             


Met Pro Met Lys Leu Pro Val Lys Thr Tyr Glu Thr Asp Asn Lys Gly 
    930                 935                 940                 


Asn Ile Leu Lys Glu Arg Pro Leu Ala Thr Phe Tyr Ile Glu Glu Thr 
945                 950                 955                 960 


Glu Thr Lys Val Leu Lys Gln Gly Asn Phe Lys Val Leu Ala Lys Asp 
                965                 970                 975     


Arg Arg Leu Asn Gly Leu Leu Ser Phe Ala Glu Thr Thr Asp Ile Asp 
            980                 985                 990         


Leu Glu Lys Asn Pro Ile Thr Lys  Leu Ser Val Asp His  Glu Leu Ile 
        995                 1000                 1005             


Lys Tyr  Gln Thr Thr Arg Ile  Ser Ile Phe Glu Met  Thr Leu Gly 
    1010                 1015                 1020             


Leu Glu  Lys Lys Leu Ile Asp  Lys Tyr Ser Thr Leu  Pro Thr Asp 
    1025                 1030                 1035             


Ser Phe  Arg Asn Met Leu Glu  Arg Trp Leu Gln Cys  Lys Ala Asn 
    1040                 1045                 1050             


Arg Pro  Glu Leu Lys Asn Tyr  Val Asn Ser Leu Ile  Ala Val Arg 
    1055                 1060                 1065             


Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met Tyr Asp  Ala Thr Leu 
    1070                 1075                 1080             


Phe Ala  Glu Val Lys Lys Phe  Thr Leu Phe Pro Ser  Val Asp Thr 
    1085                 1090                 1095             


Lys Lys  Ile Glu Leu Asn Ile  Ala Pro Gln Leu Leu  Glu Ile Val 
    1100                 1105                 1110             


Gly Lys  Ala Ile Lys Glu Ile  Glu Lys Ser Glu Asn  Lys Asn 
    1115                 1120                 1125         


<210>  1629
<211>  1175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1629

Met Thr Glu Gln Asn Glu Arg Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Phe Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Ala His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Tyr Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Gly Lys Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Thr Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Leu Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Glu Glu Ala 
            500                 505                 510         


Ser Ala Glu Lys Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Asp Glu Ile Asn Thr Arg Asp 
    530                 535                 540                 


Glu Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Ile Arg Lys Lys Leu Gln Glu Met Met Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Ser Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly His Asp Glu Val Ala Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Asp Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Asp Leu Glu Ala Trp Ser Gln Ser Ala Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Ala Gly Ile Glu Asn Ala Ser Arg Glu Asn 
    850                 855                 860                 


Lys Lys Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Lys Ala 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Arg Gly Asp Lys Ile Asn Ile Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Ala Lys Glu His Pro Tyr His Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asp Ile Arg Thr 
945                 950                 955                 960 


Glu Val Gln Glu Gln Gly Ser Leu Asn Val Leu Asn Arg Val Lys Pro 
                965                 970                 975     


Met Arg Leu Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val 
            980                 985                 990         


His Lys Glu Gln Ala Pro Leu Ala  Thr Val Tyr Ile Glu  Glu Arg Asp 
        995                 1000                 1005             


Thr Lys  Leu Leu Lys Gln Gly  Asn Phe Lys Ser Phe  Val Lys Asp 
    1010                 1015                 1020             


Arg Arg  Leu Asn Gly Leu Phe  Ser Phe Val Asp Thr  Gly Gly Leu 
    1025                 1030                 1035             


Ala Met  Glu Gln Tyr Pro Ile  Ser Lys Leu Arg Val  Glu Tyr Glu 
    1040                 1045                 1050             


Leu Ala  Lys Tyr Gln Thr Ala  Arg Val Cys Ala Phe  Glu Gln Thr 
    1055                 1060                 1065             


Leu Glu  Leu Glu Glu Ser Leu  Leu Thr Arg Tyr Pro  His Leu Pro 
    1070                 1075                 1080             


Asp Lys  Asn Phe Arg Lys Met  Leu Glu Ser Trp Ser  Asp Pro Leu 
    1085                 1090                 1095             


Leu Asp  Lys Trp Pro Asp Leu  Gln Arg Glu Val Arg  Leu Leu Ile 
    1100                 1105                 1110             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1115                 1120                 1125             


Glu Ala  Val Phe Ser Ser Ile  Arg Lys Tyr Asp Pro  Ser Ser Pro 
    1130                 1135                 1140             


Asp Ala  Ile Glu Glu Arg Met  Gly Leu Asn Ile Ala  His Arg Leu 
    1145                 1150                 1155             


Ser Glu  Glu Val Lys Gln Ala  Lys Glu Met Ala Glu  Arg Ile Ile 
    1160                 1165                 1170             


Gln Ala  
    1175 


<210>  1630
<211>  1149
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1630

Met Met Glu Lys Glu Asn Val Gln Gly Ser His Ile Tyr Tyr Glu Pro 
1               5                   10                  15      


Thr Asp Lys Cys Phe Trp Ala Ala Phe Tyr Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Leu Thr Val Ala His Ile Asn Ser Phe Val Asn Ser Lys Lys 
        35                  40                  45              


Gly Ile Asn Asn Asp Asp Lys Val Leu Asp Val Ile Asp Ala Trp Ser 
    50                  55                  60                  


Lys Phe Asp Ala Asp Leu Leu Met Gly Ala Arg Leu Asn Lys Leu Ile 
65                  70                  75                  80  


Leu Lys His Phe Pro Phe Leu Lys Ala Pro Leu Tyr Lys Gln Thr Lys 
                85                  90                  95      


Lys Glu Ala Ser Lys Gln Tyr Lys Glu Glu Asn Pro Ser Ala Asp Lys 
            100                 105                 110         


Gln Lys Ile Glu Lys Glu Ser Ala Lys Thr Ala Met Ala Asn Thr Leu 
        115                 120                 125             


Glu Leu Glu Asn Val Arg Lys Ile Leu Arg Glu Phe Leu Gln Gln Leu 
    130                 135                 140                 


Glu Asp Leu Arg Asn His Phe Ser His Tyr Asn Tyr Asn Ser Pro Asp 
145                 150                 155                 160 


Glu Lys Thr Glu Val Lys Phe Asp Asn Ser Phe Cys Asn Lys Leu Tyr 
                165                 170                 175     


Tyr Val Phe Asp Ala Ala Leu Gln Met Val Lys Asp Asp Asn Arg Met 
            180                 185                 190         


Asn Pro Glu Ile Asn Met Gln Thr Asp Phe Glu His Leu Val Arg Leu 
        195                 200                 205             


Gly Pro Asn Gly Glu Ile Ser His Ser Phe Lys Tyr Lys Phe Ile Glu 
    210                 215                 220                 


Pro Asp Gly Thr Ile Asn Asn Asn Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Lys Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Asn Tyr Met Arg Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Asn Arg Met Val Ile Pro Lys Leu Arg Leu Glu Thr Asp Tyr 
        275                 280                 285             


Asp Asn His Gln Leu Met Phe Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Leu Ser Leu Tyr Lys Arg Leu Lys Lys Glu Asp Gln Asp Lys Phe 
305                 310                 315                 320 


Gln Val Pro Ile Glu Phe Leu Asp Glu Asp Asn Glu Ala Asp Asn Gln 
                325                 330                 335     


Tyr Gln Glu Asn Ala Asn Ser Asp Glu Asn Pro Thr Glu Glu Thr Asp 
            340                 345                 350         


Pro Leu Lys Asn Thr Leu Val Arg His Gln His Arg Phe Pro Tyr Phe 
        355                 360                 365             


Val Leu Arg Tyr Phe Asp Leu Asn Glu Val Phe Lys Gln Leu Arg Phe 
    370                 375                 380                 


Gln Ile Asn Leu Gly Cys Tyr His Phe Ser Ile Tyr Asp Lys Thr Ile 
385                 390                 395                 400 


Gly Glu Arg Thr Glu Lys Arg His Leu Thr Arg Thr Leu Phe Gly Phe 
                405                 410                 415     


Asp Arg Leu Gln Asn Phe Ser Val Lys Leu Gln Pro Gln His Trp Lys 
            420                 425                 430         


Asn Met Val Lys His Leu Asp Thr Glu Glu Ser Ser Asp Lys Pro Tyr 
        435                 440                 445             


Leu Ser Asp Ala Met Pro His Tyr Gln Ile Glu Asn Glu Lys Ile Gly 
    450                 455                 460                 


Ile His Phe Leu Lys Thr Asp Thr Glu Lys Lys Glu Thr Val Trp Pro 
465                 470                 475                 480 


Ser Leu Glu Val Glu Glu Val Ser Ser Asn Arg Asn Lys Tyr Lys Ser 
                485                 490                 495     


Glu Lys Asn Leu Thr Ala Asp Ala Phe Leu Ser Thr His Glu Leu Leu 
            500                 505                 510         


Pro Met Met Phe Tyr Tyr Gln Leu Leu Ser Ser Glu Glu Lys Thr Arg 
        515                 520                 525             


Ala Ala Ala Gly Asp Lys Val Gln Gly Val Leu Gln Ser Tyr Arg Lys 
    530                 535                 540                 


Lys Ile Phe Asp Ile Tyr Asp Asp Phe Ala Asn Gly Thr Ile Asn Ser 
545                 550                 555                 560 


Met Gln Lys Leu Asp Glu Arg Leu Ala Lys Asp Asn Leu Leu Ser Gly 
                565                 570                 575     


Asn Met Pro Gln Gln Met Leu Ala Ile Leu Glu His Gln Glu Pro Asp 
            580                 585                 590         


Met Glu Gln Lys Ala Lys Glu Lys Leu Asp Leu Leu Ile Thr Glu Thr 
        595                 600                 605             


Glu Glu Arg Ile Asp Lys Leu Asn Ala Gln Phe Lys Gln Lys Val Arg 
    610                 615                 620                 


Ile Gly Lys Arg Arg Ala Gly Leu Pro Lys Val Gly Ser Ile Ala Asp 
625                 630                 635                 640 


Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Ala Lys Arg Ser Ala 
                645                 650                 655     


Asp Asn Thr Gly Val Pro Gly Ser Lys Ala Asn Ser Thr Glu Tyr Arg 
            660                 665                 670         


Leu Leu Gln Glu Ala Leu Ala Phe Tyr Ser Thr Tyr Lys Asp Arg Leu 
        675                 680                 685             


Glu Pro Tyr Phe Arg Gln Val Asn Leu Ile Gly Asp Thr Asn Pro His 
    690                 695                 700                 


Pro Phe Leu His Arg Val Asp Trp Lys Lys Cys Asn His Leu Leu Ser 
705                 710                 715                 720 


Phe Tyr His Asp Tyr Leu Glu Ala Lys Lys Arg Tyr Leu Ser Asn Leu 
                725                 730                 735     


Ser Pro Ala Asp Trp Gln Lys His Gln His Phe Leu Leu Leu Lys Val 
            740                 745                 750         


Arg Lys Asp Ile Gln Asn Glu Lys Lys Asp Trp Lys Lys Ser Leu Val 
        755                 760                 765             


Ala Gly Trp Lys Asn Gly Phe Asn Leu Pro Arg Gly Leu Phe Thr Glu 
    770                 775                 780                 


Ser Ile Lys Thr Trp Phe Ser Thr His Ala Asp Lys Val Gln Ile Thr 
785                 790                 795                 800 


Asp Thr Lys Leu Phe Glu Asn Arg Val Gly Leu Ile Ala Lys Leu Ile 
                805                 810                 815     


Pro Leu Tyr Tyr Asp Lys Val Tyr Asn Asp Lys Pro Gln Pro Phe Tyr 
            820                 825                 830         


Gln Tyr Pro Phe Asn Ile Asn Asp Arg Tyr Lys Pro Glu Asp Ala His 
        835                 840                 845             


Lys Gln Phe Thr Ala Ala Ser Ser Lys Leu Trp Asn Glu Lys Lys Met 
    850                 855                 860                 


Leu Tyr Lys Asn Ala Gln Pro Asp Ser Ser Asp Lys Ile Glu Tyr Pro 
865                 870                 875                 880 


Gln Tyr Leu Asp Phe Leu Ser Trp Lys Lys Leu Glu Arg Glu Leu Arg 
                885                 890                 895     


Met Leu Arg Asn Gln Asp Met Met Val Trp Leu Met Cys Lys Asp Leu 
            900                 905                 910         


Phe Ala Gln Cys Thr Val Glu Gly Val Glu Phe Ala Asp Leu Lys Leu 
        915                 920                 925             


Ser Gln Leu Glu Val Asp Val Thr Val Gln Asp Asn Leu Asn Val Leu 
    930                 935                 940                 


Asn Asn Val Ser Ser Met Ile Leu Pro Leu Ser Val Tyr Pro Ser Asp 
945                 950                 955                 960 


Ala Gln Gly Asn Ile Leu Arg Asn Ser Lys Pro Leu His Thr Val Tyr 
                965                 970                 975     


Val Gln Glu Lys Asn Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ser 
            980                 985                 990         


Leu Leu Lys Asp Arg Arg Leu Asn  Gly Leu Phe Ser Phe  Ile Ala Ala 
        995                 1000                 1005             


Glu Gly  Glu Asp Leu Gln Gln  His Pro Leu Thr Lys  Asn Arg Leu 
    1010                 1015                 1020             


Glu Tyr  Glu Leu Ser Ile Tyr  Gln Thr Met Arg Ile  Ser Val Phe 
    1025                 1030                 1035             


Glu Gln  Thr Leu Gln Leu Glu  Lys Ala Ile Leu Thr  Arg Asn Glu 
    1040                 1045                 1050             


Met Leu  Cys Gly Asn Asn Phe  Asn Asn Leu Leu Asn  Ser Trp Ser 
    1055                 1060                 1065             


Glu Tyr  Arg Thr Asp Lys Lys  Thr Leu Gln Pro Asp  Ile Asp Phe 
    1070                 1075                 1080             


Leu Ile  Ala Val Arg Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met 
    1085                 1090                 1095             


Ser Thr  Asn Thr Val Met Gln  Gly Ile Glu Lys Phe  Asn Ile Arg 
    1100                 1105                 1110             


Thr Ser  Arg Leu Ala Glu Lys  Asp Gly Leu Gly Ile  Ala Ser Gln 
    1115                 1120                 1125             


Leu Ala  Lys Lys Thr Lys Asp  Ala Ala Ser Arg Leu  Gln Asn Ile 
    1130                 1135                 1140             


Ile Asn  Gly Gly Thr Asn 
    1145                 


<210>  1631
<211>  1145
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1631

Met Glu Thr Leu Thr Ile Pro Glu Val Ile Lys Cys Arg Thr Leu Ser 
1               5                   10                  15      


Asp Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Ile Ala Lys Glu Phe Asp Leu Pro Leu 
        35                  40                  45              


Leu Ala Glu Glu Gly His Leu Lys Asn Ser Phe Leu Cys Lys Lys Glu 
    50                  55                  60                  


His Asn Lys Val Asn Trp Asn His Val Tyr Ser Arg Thr Lys Arg Phe 
65                  70                  75                  80  


Leu Ala Val Leu Lys Val Phe Asp Ala Glu Thr Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Lys Thr Ile Asn Trp Glu Gly Lys Asp Phe Ala Ser Met Ser Asp 
            100                 105                 110         


Ile Leu Lys Ile Val Phe Gly Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Thr Ile Arg Lys Thr Ala Val 
    130                 135                 140                 


Ser Ala Glu Met Ala Leu Phe Leu Thr Thr Asn Phe Arg Arg Ala Ile 
145                 150                 155                 160 


Glu Tyr Thr Lys Glu Arg Phe Lys Gly Val Leu Asn Asp Glu Asp Tyr 
                165                 170                 175     


Gln Leu Val Ala Ser Lys Lys Val Leu Glu Ala Asn Ser Thr Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Arg Phe Ile Gly Ile Ile Thr Gly Leu Lys Gly Thr Gln Asn 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro His Asp Arg Phe Gln Ser Asp Asn Pro Arg Gln Ala Phe Ser 
                245                 250                 255     


Leu Asp Leu Ile Asn Glu Leu Asn Arg Cys Pro Lys Val Leu Tyr Asn 
            260                 265                 270         


Ala Ile Thr Glu Glu Gly Lys Gln Lys Leu Arg Ser Ile Pro Gly Glu 
        275                 280                 285             


Leu Glu Asn Lys Asn Leu His Asp Asn Asn Thr Lys Lys Glu Ala Lys 
    290                 295                 300                 


Ile Glu Ala Glu Ala Tyr Glu Leu Tyr Ile Glu Ser Leu Thr Arg Gln 
305                 310                 315                 320 


Ile Arg Tyr Ser Asn Arg Phe Pro Asp Phe Ala Leu Lys Phe Ile Asp 
                325                 330                 335     


Glu Thr Asp Ile Phe Ser Glu Phe Arg Phe Gln Ile Asp Leu Gly Lys 
            340                 345                 350         


Leu Leu Val Asp Glu Tyr Leu Lys Phe Phe Asn Gly Glu His Val Gln 
        355                 360                 365             


Arg Arg Ile Val Glu Asn Ala Lys Ala Phe Gly Lys Leu Ile Asp Phe 
    370                 375                 380                 


Asn Asp Glu Ala Lys Val Met Thr Arg Ile Gly Asn Gly His Phe Ser 
385                 390                 395                 400 


Lys Arg Phe Glu Gln Phe Ala Pro Phe Tyr Asn Thr Glu Asp Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Arg His His Val Thr Ala Lys Leu Gly Pro Asp Ser 
            420                 425                 430         


Lys Gly Glu Pro Glu Lys Lys Leu Leu Gln Pro Leu Pro Glu Ala Phe 
        435                 440                 445             


Leu Ser Leu His Glu Leu Pro Lys Val Ile Leu Leu Asp Tyr Leu Gln 
    450                 455                 460                 


Lys Gly Glu Pro Glu Lys Leu Ile Asn Asp Phe Ile Leu Ile Asn Asn 
465                 470                 475                 480 


Ser Lys Leu Met Asn Met Ser Phe Ile Glu Ala Val Lys Thr Gln Leu 
                485                 490                 495     


Pro Pro Glu Trp Asp Glu Phe Gln Arg Arg Thr Gly Ser Lys Asn Glu 
            500                 505                 510         


Met Pro Tyr Asn Glu Lys Thr Leu Ala Tyr Leu Leu Gln Arg Lys Gln 
        515                 520                 525             


Ile Leu Asn Lys Ile Leu Ala Glu Phe Gln Leu Asn Asp Lys Gln Ile 
    530                 535                 540                 


Pro Gly Arg Ile Leu Asp Tyr Trp Leu Asn Ile Ala Asp Val Glu Glu 
545                 550                 555                 560 


Glu Arg Ala Val Ser Asp Arg Ile Lys Ser Ile Lys Arg Asp Cys Met 
                565                 570                 575     


Ser Arg Leu Arg Ala Leu Gly Lys Phe Lys Ile Asp Arg Asn Arg Asn 
            580                 585                 590         


Lys Ile Pro Lys Ile Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile 
        595                 600                 605             


Val Asp Met Val Val Ser Glu Gly Lys Lys His Lys Ile Thr Ser Phe 
    610                 615                 620                 


Tyr Tyr Glu Lys Met Gln Asp Cys Leu Ser Leu Phe Ala Asp Pro Leu 
625                 630                 635                 640 


Lys Arg Gln Leu Phe Ile His Ile Ile Thr Asn Glu Leu Arg Leu Asn 
                645                 650                 655     


Asp Ser Gly Gly His Pro Phe Leu Phe Lys Leu Asn Met Arg Gln Ile 
            660                 665                 670         


Asn Cys Thr Ser Asp Phe Tyr Glu Ile Tyr Leu Gln Glu Lys Gly His 
        675                 680                 685             


Lys Met Val Pro Glu Lys Asn Leu Lys Thr Gly Lys Val Val Asn Thr 
    690                 695                 700                 


Asp His Ser Trp Met Ala Leu Thr Phe Tyr Lys Leu Glu Phe Asn Asp 
705                 710                 715                 720 


Lys Val Asp Lys Leu Met Thr Val Val Lys Leu Pro Leu Asn Lys Leu 
                725                 730                 735     


Asn Leu Pro Phe Thr Leu Arg Gln Leu Asn Ala Lys Thr Thr Tyr Thr 
            740                 745                 750         


Leu Glu Gln Trp Leu Lys Asn Leu Thr Leu Gly Lys Lys Pro Asp Asp 
        755                 760                 765             


Gly Lys His Pro Val Asn Leu Pro Thr Asn Leu Phe Asp Glu Lys Leu 
    770                 775                 780                 


Ser Asp Leu Leu Arg Gln Asp Leu Asp Asn Asn Lys Ile Ala Tyr Arg 
785                 790                 795                 800 


Pro Tyr Ala Asn Trp Asn Glu Leu Phe Lys Ile Trp Trp Ile Ser Arg 
                805                 810                 815     


Asn Asp Ser Leu Gln Arg Phe Tyr Asn Ala Glu Arg Glu Tyr His Ile 
            820                 825                 830         


Phe Asn Glu Lys Val Asn Phe Tyr Pro Asn Arg Lys Glu Asn Phe Ala 
        835                 840                 845             


Asp Tyr Tyr Gln His Ala Val Lys Val Ala Phe Gln Lys Lys Arg Asn 
    850                 855                 860                 


Glu Arg Ile Ile Glu Gln Arg Ile Asn Lys Tyr Leu Pro Asp Ile Leu 
865                 870                 875                 880 


Phe Glu Gln Val Glu Lys Thr Phe Lys His Thr Ile Ala Glu Thr Glu 
                885                 890                 895     


Lys Glu Ile Arg Ile Leu Gln Glu Glu Asp Arg Ile Met Leu Leu Met 
            900                 905                 910         


Leu Glu Gly Leu Met Glu Asp Gly Asn Lys Gln Gln Leu Lys Leu Ser 
        915                 920                 925             


Glu Ile Lys Thr Leu Gln Asn Ala Thr Ile Asn Ile Arg Gln Leu Val 
    930                 935                 940                 


Pro Gly Lys Leu Ser Phe Asp Asp Ser Gly Glu Ala Ile Lys Asp Ser 
945                 950                 955                 960 


Thr Asn Pro Glu Ile Val Arg Thr Val Ser Val Ser Ile Lys Arg Ile 
                965                 970                 975     


Glu Tyr Asn Leu Leu Pro Lys Tyr Val Ala Asp Gly Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Pro Asp Glu  Glu Ile Gln Met Glu  Arg Leu Lys 
        995                 1000                 1005             


Thr Glu  Phe Asp Thr Tyr Asn  Lys Val Arg Gln Val  Val Leu Asp 
    1010                 1015                 1020             


Leu Ser  Phe Lys Leu Glu Lys  Met Ile Ile Glu Lys  Gly His Lys 
    1025                 1030                 1035             


Asp Arg  Ile Asn Gln Leu Cys  Thr Gly Ala Thr Gly  Glu Leu Leu 
    1040                 1045                 1050             


Thr Gly  Asn Ile Cys His His  Thr Tyr Leu Thr Trp  Leu Lys Asp 
    1055                 1060                 1065             


Lys Glu  Met Ile Asp Asn Glu  Thr Phe Ile Phe Met  Asn Met Val 
    1070                 1075                 1080             


Gln His  Cys Phe Ser His Asn  Gln Tyr Pro Gln Lys  Lys Thr Met 
    1085                 1090                 1095             


Glu Arg  Ile Ile Asn His Trp  Glu Pro Asp Arg Phe  Ala Leu Thr 
    1100                 1105                 1110             


Ile Ala  Ala Thr Tyr Asn Gln  Lys Ile Ala Gly Ile  Leu Glu Asp 
    1115                 1120                 1125             


Ile Gly  Thr Phe Pro Phe Ile  Arg Ser Arg Lys Thr  Met Pro Asp 
    1130                 1135                 1140             


Val Val  
    1145 


<210>  1632
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1632

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Met Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Met Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1633
<211>  1175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1633

Met Thr Glu Gln Asn Glu Arg Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Ala His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Met Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Cys Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Gly Thr Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Ala Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Gly Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Phe Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Asp Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Gly Glu Ile Asp Thr Arg Asp 
    530                 535                 540                 


Glu Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Glu Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Ser Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Tyr Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Asp Leu Glu Ala Trp Ser His Ser Ala Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Val Gly Ile Glu Tyr Ala Ser Trp Glu Asn 
    850                 855                 860                 


Lys Lys Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Glu Thr 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Lys Ala Asp Lys Ile Asn Ile Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Ala Lys Glu His Pro Tyr Leu Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asp Ile Arg Thr 
945                 950                 955                 960 


Glu Val Gln Glu Gln Gly Ser Leu Asn Val Leu Asn Arg Val Lys Pro 
                965                 970                 975     


Met Arg Leu Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val 
            980                 985                 990         


His Lys Glu Gln Ala Pro Leu Ala  Thr Val Tyr Ile Glu  Glu Arg Asp 
        995                 1000                 1005             


Thr Lys  Leu Leu Lys Gln Gly  Asn Phe Lys Ser Phe  Val Lys Asp 
    1010                 1015                 1020             


Arg Arg  Leu Asn Gly Leu Phe  Ser Phe Val Asp Thr  Gly Ala Leu 
    1025                 1030                 1035             


Ala Met  Glu Gln Tyr Pro Ile  Ser Lys Leu Arg Val  Glu Tyr Glu 
    1040                 1045                 1050             


Leu Ala  Lys Tyr Gln Thr Ala  Arg Val Cys Ala Phe  Glu Gln Thr 
    1055                 1060                 1065             


Leu Glu  Leu Glu Glu Ser Leu  Leu Thr Arg Tyr Pro  His Leu Pro 
    1070                 1075                 1080             


Asp Glu  Ser Phe Arg Glu Met  Leu Glu Ser Trp Ser  Asp Pro Leu 
    1085                 1090                 1095             


Leu Asp  Lys Trp Pro Asp Leu  Gln Arg Glu Val Arg  Leu Leu Ile 
    1100                 1105                 1110             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1115                 1120                 1125             


Glu Thr  Ile Phe Ser Ser Ile  Arg Lys Tyr Asp Pro  Ser Ser Pro 
    1130                 1135                 1140             


Asp Ala  Ile Glu Glu Arg Met  Gly Leu Asn Ile Ala  His Arg Leu 
    1145                 1150                 1155             


Ser Glu  Glu Val Lys Gln Ala  Lys Glu Met Ala Glu  Arg Ile Ile 
    1160                 1165                 1170             


Gln Ala  
    1175 


<210>  1634
<211>  1119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1634

Met Thr Glu Gln Asn Glu Arg Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Thr His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Lys Tyr Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Glu Lys Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Ala Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln Leu Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Phe Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Glu Glu Val 
            500                 505                 510         


Ser Ala Glu Lys Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Asp Glu Ile Asn Thr Arg Asp 
    530                 535                 540                 


Glu Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp Arg 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Thr Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Gly Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly His Asp Glu Val Ala Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Ser Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asn Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Glu Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Leu Ala Lys Leu Lys Lys Glu Ile Leu Glu Ala 
        835                 840                 845             


Lys Glu His Pro Tyr Leu Asp Phe Lys Ser Trp Gln Lys Phe Glu Arg 
    850                 855                 860                 


Glu Leu Arg Leu Val Lys Asn Gln Asp Ile Ile Thr Trp Met Met Cys 
865                 870                 875                 880 


Arg Lys Leu Val Glu Glu Asn Lys Val Glu Gly Leu Asp Thr Gly Thr 
                885                 890                 895     


Leu Tyr Leu Lys Asp Ile Arg Thr Asp Val Gln Glu Gln Gly Asn Leu 
            900                 905                 910         


Asn Val Leu Asn Arg Val Lys Pro Met Arg Leu Pro Val Val Val Tyr 
        915                 920                 925             


Arg Ala Asp Ser Arg Gly His Val His Lys Glu Gln Ala Pro Leu Ala 
    930                 935                 940                 


Thr Val Tyr Ile Glu Glu Arg Asp Thr Lys Leu Leu Lys Gln Gly Asn 
945                 950                 955                 960 


Phe Lys Ser Phe Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe 
                965                 970                 975     


Val Asp Thr Gly Gly Leu Ala Met Glu Gln Tyr Pro Ile Ser Lys Leu 
            980                 985                 990         


Arg Val Glu Tyr Glu Leu Ala Lys  Tyr Gln Thr Ala Arg  Val Tyr Val 
        995                 1000                 1005             


Phe Glu  Gln Thr Leu Glu Leu  Glu Glu Ser Leu Leu  Thr Arg Tyr 
    1010                 1015                 1020             


Pro His  Leu Pro Asp Lys Ser  Phe Arg Glu Met Leu  Glu Ser Trp 
    1025                 1030                 1035             


Ser Asp  Pro Leu Leu Asp Lys  Trp Pro Asp Leu Gln  Arg Lys Val 
    1040                 1045                 1050             


Arg Leu  Leu Ile Ala Val Arg  Asn Ala Phe Ser His  Asn Gln Tyr 
    1055                 1060                 1065             


Pro Met  Tyr Asp Glu Ala Val  Phe Ser Pro Ile Arg  Lys Tyr Asp 
    1070                 1075                 1080             


Pro Ser  Ser Pro Asp Ala Ile  Glu Glu Arg Met Gly  Leu Asn Ile 
    1085                 1090                 1095             


Ala His  Arg Leu Ser Gly Glu  Val Lys Leu Ala Lys  Glu Met Val 
    1100                 1105                 1110             


Glu Arg  Ile Ile Gln Ala 
    1115                 


<210>  1635
<211>  1300
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1635

Met Cys Ile Phe Ala Lys Leu Asn Ile Gln Met Pro Ser Asn Asn Asn 
1               5                   10                  15      


Ser Leu Asn Gln Phe Ile Thr Thr Met Asp Asn Asn Glu Thr Ser Ile 
            20                  25                  30          


Lys Gln Phe Val Leu Leu Gly Glu Asp Asn Ser Gln Tyr Arg Asp Tyr 
        35                  40                  45              


Ala Gly Ser Tyr Phe Thr Lys Ala Asn Leu Asn Phe Tyr Arg Thr Met 
    50                  55                  60                  


Lys Thr Val Phe Arg Arg Ser Gly Ile Met Lys Asp Asn Arg Leu Gly 
65                  70                  75                  80  


Asn Val Glu Trp Arg Asp Asp Asn Met Glu Thr Ala Leu Ser Ser Phe 
                85                  90                  95      


Asp Ile Thr Thr Ile Ser Ala Thr Gln Met Ser Ser Leu Ser Asp His 
            100                 105                 110         


Leu Phe Arg Asn Leu Pro Met Phe Gly Pro Ile Met Ser His Asp Lys 
        115                 120                 125             


Asn Ala Phe Leu Ser Pro Leu Lys Arg Ala Lys Lys Thr Phe Asp Lys 
    130                 135                 140                 


Ala Lys Lys Asp Leu Lys Asn Ala Lys Lys Thr His Gln Asp Glu Val 
145                 150                 155                 160 


Lys Tyr Glu Lys Leu Lys Lys Glu Ala Glu Lys Glu Tyr Asn Gln Gln 
                165                 170                 175     


Lys Glu Asn Phe Lys Asn Glu Met Tyr Gly Thr Glu Ala Lys Asp Met 
            180                 185                 190         


Trp Asp Lys Leu Ile Asn Ile Ala Gly Ala Leu Leu Tyr Tyr Arg Asn 
        195                 200                 205             


Leu Tyr Thr His Lys Asn Pro Tyr Ser Thr Glu Asp Asp Glu Asn Lys 
    210                 215                 220                 


Gln Lys Glu Arg Glu Ile Lys Ile Ala Lys Trp Met Asn Ser Val Phe 
225                 230                 235                 240 


Glu Gly Glu Lys Gly Ile Leu Ile Glu Arg Lys Lys Tyr Lys Tyr Glu 
                245                 250                 255     


Asp Thr Leu Phe Leu Ile Asp His Gln Lys Glu Thr Asp Arg Met Glu 
            260                 265                 270         


Lys Arg Gly Asn Lys Tyr Val Glu Arg Asp Asn Phe Tyr Phe Lys Ile 
        275                 280                 285             


Lys Ile Leu Asp Glu Asn Asn Lys Cys Leu Gly Leu Thr Asp Phe Gly 
    290                 295                 300                 


Arg Phe Phe Phe Cys Ser Leu Phe Leu Arg Arg Ser Asp Ser Glu Leu 
305                 310                 315                 320 


Tyr Ala Lys Ser Val Lys Leu Phe Glu Asn Ser Pro Tyr Cys Leu Thr 
                325                 330                 335     


Glu Gln Glu Leu Lys Ile Lys Gln Ala Glu Glu Asn Lys Arg Ala Ser 
            340                 345                 350         


Thr Glu Ser Gln Lys Ser Asp His Gln Val Asn Pro Lys Thr Ile Asp 
        355                 360                 365             


Lys Thr Glu Ser Ala Gln Ile Asn Ile Ile Arg Glu Met Met Gln Met 
    370                 375                 380                 


His Arg Ile Arg Ile Pro Arg Glu Lys Lys Ile Asp Phe Thr Pro Ser 
385                 390                 395                 400 


Glu Ser Met Leu Leu Met Asp Ile Leu Asn Glu Leu Arg Arg Cys Pro 
                405                 410                 415     


Gln Glu Leu Tyr Asp Thr Phe Asn Gln Thr Asp Lys Leu Lys Phe Val 
            420                 425                 430         


Val Asp Asn Pro Asn Glu Asp Pro Glu Ser Asp Ser Lys Ile Thr Leu 
        435                 440                 445             


Thr Arg Ser Lys Asp Arg Phe Ala His Leu Ala Leu Arg Leu Ile Asp 
    450                 455                 460                 


His Thr Asp Ala Leu Gly Ser Ile Arg Phe His Leu Arg Leu Gly Leu 
465                 470                 475                 480 


Phe Arg Phe Arg Phe Tyr Asp Lys Lys Leu Ile Asp Asn Ser Glu Thr 
                485                 490                 495     


Leu Arg Arg Val His Lys Glu Ile Asn Gly Phe Gly Lys Trp His Val 
            500                 505                 510         


Val Glu Ser Leu Arg Arg Glu Lys Trp Gly Lys Tyr Asn Gln Lys Phe 
        515                 520                 525             


Glu Leu Asn Asp Asp Gly Leu Leu Gln Phe Val Pro Asp Ser Ala Glu 
    530                 535                 540                 


Ser Asp Pro Tyr Ile Thr Asp Trp Gln Thr Thr Tyr Asn Ile His Ala 
545                 550                 555                 560 


Asn Arg Ile Gly Leu Phe Trp Asn Gly Asn Ser Gln Ser Glu Asp Tyr 
                565                 570                 575     


Tyr Ile Pro Glu Leu Lys Thr Met Val Asp Glu Asn Ser Lys Val Ile 
            580                 585                 590         


Ala Pro Val Glu Met Lys Ile Pro Leu Cys Ser Leu Ser Ile Tyr Asp 
        595                 600                 605             


Leu Pro Ala Ile Leu Phe Tyr Thr Tyr Ile Phe Asn Leu Tyr Asn Gly 
    610                 615                 620                 


Asn Arg Leu Gly Leu Pro Asn Ala Glu Lys Ile Ile Lys Asn Lys Tyr 
625                 630                 635                 640 


Thr Ala Leu Asn Glu Phe Phe Gly Phe Ala Lys Lys Ser Glu Ser Thr 
                645                 650                 655     


Pro Glu Glu Leu Ile Lys Lys Gln Glu Glu Leu Asn Leu His Asp Ser 
            660                 665                 670         


Glu Ile Pro Glu Arg Leu Leu Tyr Leu Met Gly Lys Ile Lys Thr Pro 
        675                 680                 685             


Lys Gly Lys Met Ala Glu Trp Lys Pro Asn Ser Lys Arg Asn Asn His 
    690                 695                 700                 


Ala Lys Glu Leu Leu Lys Lys Ile Ile Glu Glu Asp Glu Trp Arg Ile 
705                 710                 715                 720 


Lys Ser Phe Lys Asp Lys Lys Asn Lys Ile Glu Asp Lys Asn Arg Tyr 
                725                 730                 735     


Gly Arg Lys Asp Tyr Ser Asp Ile Arg His Gly Val Leu Ala Lys Tyr 
            740                 745                 750         


Leu Val Glu Ser Met Met Met Trp Gln Pro Gly Lys Gln Lys Ala Glu 
        755                 760                 765             


Thr Lys Ile Ser Ser Ala Asn Tyr Arg Ala Leu Arg Asp Tyr Leu Ser 
    770                 775                 780                 


Asn Tyr Asn Asn Ser Ser Asn Asn Leu Gln Tyr Val Leu Glu Ala Ala 
785                 790                 795                 800 


His Leu Ile Asp Ser Glu Asn Pro His Pro Phe Ile Asp Lys Val Lys 
                805                 810                 815     


Gly Ser Asn Ile Glu Leu Tyr Tyr Thr Asn Tyr Leu His Glu Glu Leu 
            820                 825                 830         


Lys His Ala Arg Gly Ile Leu Ala Lys Leu Glu Asp Asn Asn Tyr Thr 
        835                 840                 845             


Gly Asp Lys Lys Asp Ile Ile Pro Pro Phe Ala Lys Pro Glu Ser Asp 
    850                 855                 860                 


Lys Trp Asn Lys Lys Ser Asn Thr Ile Gln Ser Cys Ala Ala Lys Tyr 
865                 870                 875                 880 


Leu Glu His Pro Leu Gln Leu Pro Asp Gly Leu Phe Thr Gln Ala Ile 
                885                 890                 895     


Ile Asp Leu Leu Lys Ala Ala Asp Ile Asp Glu Thr Ile Lys Asn Asp 
            900                 905                 910         


Ala Thr Lys Asp Ser Asn Ala Thr Tyr Ile Ile Arg Tyr Trp Phe Asp 
        915                 920                 925             


Lys Val Gly Gln Asp Ser Pro Gln Leu Phe Tyr Asp Ser Thr Leu Phe 
    930                 935                 940                 


Lys Arg Ser Tyr Lys Phe Ile Asp Lys Cys Phe Leu Gln Lys Asp Glu 
945                 950                 955                 960 


Gly Asn Gln Thr Ile Lys His Phe Leu Thr Glu Lys Glu Ile Leu Asp 
                965                 970                 975     


Asn Ile Lys Ile Phe Arg Gly Glu Thr Gly Ser Leu Ala Gly Lys Leu 
            980                 985                 990         


Tyr Pro Lys Asp Lys Leu Glu Glu  Ser Lys Lys Ser Ile  Ile Asn Gln 
        995                 1000                 1005             


Leu Asn  Glu Val Lys Asp Lys  Glu Lys Ala Ile Arg  Arg Tyr Arg 
    1010                 1015                 1020             


Val Gln  Asp Ile Ala Leu Phe  Leu Leu Ala Arg Lys  Arg Leu Ala 
    1025                 1030                 1035             


Glu Leu  Leu Ser Lys Ser Glu  Asn Ser Asn Arg Asn  Glu Ala Arg 
    1040                 1045                 1050             


Ile Glu  Thr Ser Leu Ser Gln  Asn Asn Ile Ser Lys  Lys Ala Asn 
    1055                 1060                 1065             


Asn Leu  Lys Leu Lys Asp Phe  Gly Phe Asp Glu Asp  Phe His Phe 
    1070                 1075                 1080             


Leu Ser  Gly Ser Glu Asp Asn  Gly Asp Gly Leu Leu  Phe Glu Tyr 
    1085                 1090                 1095             


Glu Tyr  Ile Val Asp Asn Asp  Ala Asn Lys Lys Ile  Met Ile Val 
    1100                 1105                 1110             


Gln Glu  Gly Leu Ser Leu Lys  Asn Tyr Gly Asn Ile  Tyr Arg Val 
    1115                 1120                 1125             


Leu Gly  Asp Asn Arg Ile Lys  Thr Leu Met Gln Leu  Leu Tyr Glu 
    1130                 1135                 1140             


Ile Lys  Lys Asp Lys Val Glu  Asp Gly Thr Ile Thr  Phe Thr Phe 
    1145                 1150                 1155             


Ala Glu  Leu Val Lys Glu Leu  Thr Asn Asn Asp Lys  Leu His His 
    1160                 1165                 1170             


Glu Phe  Tyr Arg Leu Phe Gln  Asn Ile Glu Gln Glu  Ala Tyr Asp 
    1175                 1180                 1185             


Gly Thr  Gly Gly Phe Asp Ala  Asn Lys Lys Asn Lys  Glu Val Leu 
    1190                 1195                 1200             


Asp Asn  Pro Asp Asp Glu Gln  Phe Phe Phe Val Arg  Gln Arg Lys 
    1205                 1210                 1215             


Asn Gly  Glu Val Thr Thr Lys  Glu Ala Val Arg Asn  Ser Phe Lys 
    1220                 1225                 1230             


Lys Leu  Ile Glu Leu Leu Lys  Gln Tyr Ser Thr Asp  Glu Gly Ile 
    1235                 1240                 1245             


Ile Val  Gln Leu Arg Asn Asp  Ala Ile His Asp Arg  Tyr Pro Lys 
    1250                 1255                 1260             


Pro Asp  Ala Glu Met Glu Leu  Lys Glu Thr Gly Val  Thr Glu Ser 
    1265                 1270                 1275             


Leu Ile  Ala Tyr Leu Asn Asn  Leu Ile Lys Lys Asn  Gln Lys Gln 
    1280                 1285                 1290             


Leu Lys  Asn Gln Glu Gln Arg  
    1295                 1300 


<210>  1636
<211>  1171
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1636

Met Asn Leu Leu Glu Lys Thr Asn Ala Ala Glu Ser Cys Phe Asn His 
1               5                   10                  15      


Thr Ile Asn Asp Gln Lys Tyr Tyr Phe Ala Gly Tyr Leu Asn Leu Ala 
            20                  25                  30          


Gln Asn Asn Ile Lys Thr Leu Glu Lys Ala Tyr Gly Glu His Phe Leu 
        35                  40                  45              


Cys Ser Gly Asn Asn Pro Ile Ile Asn Asp Leu Thr Asn Thr Asn Ser 
    50                  55                  60                  


Leu Ile Asp Trp Asp Phe Lys Met Lys Phe Leu Ser Gln Tyr Leu Pro 
65                  70                  75                  80  


Ala Ile Ser Tyr Leu Asn Leu Glu Thr Asp Leu Asn Glu Ser Phe Glu 
                85                  90                  95      


Lys Arg Lys Lys Glu Phe Thr Lys Asn Leu Ser Phe Leu Phe Asn Ala 
            100                 105                 110         


Ile Asp Leu Leu Arg Asn Phe Tyr Ser His Tyr Tyr His Ala Pro Leu 
        115                 120                 125             


Ile Asp Glu Leu Asn Ser Glu Arg Leu Ile Phe Leu Asp Lys Ile Phe 
    130                 135                 140                 


Val Ala Val Cys Ile Asn Val Lys Lys Lys Arg Met Lys Asp Asp Lys 
145                 150                 155                 160 


Thr Lys Gln Leu Leu Lys Ala Thr Leu Ile Asp Glu Leu Asp Leu Leu 
                165                 170                 175     


Leu Lys Ala Lys Lys Glu Glu Leu Leu Lys Lys Lys Lys Glu Gly Lys 
            180                 185                 190         


Lys Val Ser Thr Asp Ala Ile Ser Met Lys Asn Ser Val Leu Asn Asp 
        195                 200                 205             


Ala Phe Asn His Leu Ile Gln Leu Glu Lys Asn Ser Lys Lys Glu Ile 
    210                 215                 220                 


Pro Gly Arg Tyr Tyr Thr Ser Leu Leu Asn Asp Asn Asn Lys Tyr Thr 
225                 230                 235                 240 


Glu Asn Gly Ile Asn Ile Ser Ile Ser Gly Leu Leu Phe Leu Leu Ser 
                245                 250                 255     


Met Phe Leu Thr Lys Lys Gln Asn Glu Asp Val Arg Ser Arg Ile Phe 
            260                 265                 270         


Gly Phe Lys Gly Thr Ile Glu Ser Asp Lys Gly Ile Ser Lys Ser Asn 
        275                 280                 285             


Asn Ser Phe Arg Asn Met Ala Thr Asn Trp Val Phe Ser Tyr Leu Ser 
    290                 295                 300                 


Phe Lys Gly Met Lys Lys Gln Leu Gly Ser Thr Phe Asn Lys Glu Ser 
305                 310                 315                 320 


Leu Leu Val Gln Ile Val Asp Glu Leu Ser Lys Val Pro His Glu Val 
                325                 330                 335     


Tyr Gln Thr Leu Ser Pro Ser Arg Gln Glu Met Phe Leu Glu Asp Met 
            340                 345                 350         


Asn Glu Tyr Leu Lys Asp Gly Asn Lys Lys His Cys Leu Glu Asp Ser 
        355                 360                 365             


Ile Val Val His Pro Val Ile Lys Lys Arg Tyr Glu Asp Lys Phe Asn 
    370                 375                 380                 


Tyr Phe Ala Ile Arg Tyr Leu Asp Glu Phe Val Asp Phe Pro Ser Leu 
385                 390                 395                 400 


Arg Phe Gln Val Asn Val Gly Asn Tyr Val His Asp Arg Arg Lys Lys 
                405                 410                 415     


Thr Ile Asp Gly Thr Asn Thr Glu Thr Asp Arg Met Val Lys Glu Glu 
            420                 425                 430         


Ile Arg Ala Phe Gly Lys Leu Ser Phe Ile Ser Lys Leu Lys Ala Asp 
        435                 440                 445             


Tyr Phe Ala Lys Asp Leu Pro Ser Asp Ile Ser Trp Glu Met Tyr Pro 
    450                 455                 460                 


Asn Pro Ser Tyr Asn Phe Ser Ala Asn Asn Ile Pro Val Tyr Ile Asp 
465                 470                 475                 480 


Leu Phe Lys Ser Ser Val Ala Gly Ala Ala Asp Val Gly Lys Asp His 
                485                 490                 495     


Lys Gly Tyr Gln Ala Lys Leu Asp Leu Asp Glu Asp Gly Lys Lys Arg 
            500                 505                 510         


Asn Arg Asn Glu Gly Lys Pro Asp Lys Lys Glu Ile Ala Glu Ile Leu 
        515                 520                 525             


Phe Gly Lys Lys Asn Lys Gln Ile Leu Phe Glu Lys Pro Thr Val Leu 
    530                 535                 540                 


Leu Ser Leu Asn Glu Leu Pro Ala Met Leu Tyr Glu Val Leu Ile Glu 
545                 550                 555                 560 


Asn Gly Asp Lys Gln Asp Ile Gly Lys Arg Ile Glu Asp Lys Ile Val 
                565                 570                 575     


Glu Lys Ile Ile Ala His Tyr Asn Leu Leu Asp Gln Tyr Asp Gly Thr 
            580                 585                 590         


Thr Glu Leu Pro Gly Ser Val Ile Pro Arg Lys Leu Arg Met Gly Gly 
        595                 600                 605             


Asn Glu Lys Ser Ile Asn Ile Asp Lys Leu Leu Arg Ala Val Lys Arg 
    610                 615                 620                 


Glu Leu Glu Ile Thr Gln Glu Lys Leu Asp Leu Ile Lys Thr Asn Gln 
625                 630                 635                 640 


Lys Lys Phe Lys Ser Lys Glu Lys Asp Glu Lys Gly Asn Ser Arg Gln 
                645                 650                 655     


His Val Phe Tyr Thr Asn Glu Leu Gly Gln Glu Ala Thr Trp Ile Ala 
            660                 665                 670         


Asn Asp Met Lys Arg Phe Met Pro Lys Glu Val Lys Glu Lys Trp Arg 
        675                 680                 685             


Gly Tyr His His Ser Asn Leu Gln Lys Leu Leu Ala Leu Tyr Asp Gln 
    690                 695                 700                 


Thr Arg Asn Glu Ala Val Lys Cys Ile Thr Cys Phe Trp Asn Phe Asp 
705                 710                 715                 720 


Gln Gln Thr Ser Trp Gly Lys Gly Ile Lys Glu Ala Phe Tyr Lys Ser 
                725                 730                 735     


Thr Phe Glu Glu Phe Tyr Lys Ala Tyr Leu Glu His Arg Met Asp Val 
            740                 745                 750         


Tyr Lys Thr Leu Glu Asn Asn Leu Ile Ala Gly Lys Gly Tyr Ser Lys 
        755                 760                 765             


Leu Phe Asn Lys Glu Lys Lys Lys Ala Phe Ile Leu Phe Asp Glu His 
    770                 775                 780                 


Leu Tyr Thr Ile Pro Asp Ile Asn Thr Gln Lys Glu Arg Leu Lys Ser 
785                 790                 795                 800 


Thr Leu Phe Ile Leu Pro Arg Gly Ile Phe Asp Ser Lys Pro Thr Phe 
                805                 810                 815     


Ile Lys Gly Ile Lys Tyr Glu Glu Asp Pro Ser Cys Phe Ala Asp Trp 
            820                 825                 830         


Tyr Gln Phe Ala Asn Ala Thr Gly Asn Gln Tyr Gln Arg Phe Tyr Asp 
        835                 840                 845             


Leu Pro Arg Ser Tyr Thr Ser Leu Phe Glu Glu Thr Lys Lys Asn Asn 
    850                 855                 860                 


Glu Gly Leu Ile Glu Asn Lys Lys Gly Leu Ser Ala Lys Glu Gln Leu 
865                 870                 875                 880 


Asp Phe Phe Lys Met Arg Gln Asp Leu Lys Ile Lys Lys Ile Lys Thr 
                885                 890                 895     


Gln Asp Leu Phe Leu Phe Met Ile Val Arg Asp Leu Tyr Lys Lys Val 
            900                 905                 910         


Phe Asp His Thr Leu Pro Leu Glu Ile Gly Leu Arg Asp Met Tyr Gln 
        915                 920                 925             


Thr Pro Ala Glu Arg Gln Ala Asn Tyr Asp Leu Ala Val Lys Gln Ser 
    930                 935                 940                 


Gln Arg Thr Glu Gly Asp Asn Ser Asp Asn Leu Tyr Asn Tyr Asn Phe 
945                 950                 955                 960 


Leu Trp Asn Leu Thr Ile Pro Phe Glu Tyr Asp Lys Ile Lys Glu Pro 
                965                 970                 975     


Gln Val Lys Leu Lys Asp Val Gly Lys Phe Tyr Lys Phe Ala Ala Asp 
            980                 985                 990         


Glu Lys Val Gln Thr Ile Leu Ser  Tyr Ser Asp Arg Glu  Trp Ser Lys 
        995                 1000                 1005             


Leu Asp  Leu Glu Lys Glu Leu  Glu Leu Met Pro Thr  Ser Tyr Glu 
    1010                 1015                 1020             


Val Ile  Arg Arg Glu Gln Leu  Leu Arg Asp Ile Gln  Gln Phe Glu 
    1025                 1030                 1035             


Lys Arg  Ile Leu Glu Asn Tyr  Pro Ser Asp Gly Asn  Ala His Pro 
    1040                 1045                 1050             


Ala Asp  Leu Glu Lys Glu Asp  Lys Asp Lys Lys Cys  Phe Pro Asn 
    1055                 1060                 1065             


Phe Asn  Leu Tyr Leu Leu Lys  Gly Ile Ile Ile Lys  Asn Asn Leu 
    1070                 1075                 1080             


Ala Ser  Glu Glu Glu Arg Gln  Trp Phe Glu Gln Val  His Leu Asp 
    1085                 1090                 1095             


Lys Thr  Pro Phe Tyr Pro Glu  Val Glu Thr Lys Ser  Ser Ile Ile 
    1100                 1105                 1110             


Gln Ser  Ala Tyr Leu Leu Leu  Leu Ile Arg Asn Lys  Met Leu His 
    1115                 1120                 1125             


Asn Gln  Leu Pro Ser Lys Gln  Asn Phe Glu Phe Met  Thr Thr Leu 
    1130                 1135                 1140             


Tyr Pro  Phe Glu Gly Tyr Glu  Ser Tyr Ser Thr Tyr  Leu Leu Phe 
    1145                 1150                 1155             


Val Thr  Lys Lys Thr Ile Glu  Cys Leu Ser Ser Ala  Met 
    1160                 1165                 1170     


<210>  1637
<211>  1310
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1637

Met Gly Lys Asp Tyr Lys Thr Gln Gln Pro Lys Lys Val Arg Arg Gln 
1               5                   10                  15      


Gln Lys Thr Asn Phe Ser Ile Asn Leu Thr Gly Lys His Val Phe Gly 
            20                  25                  30          


Ala Tyr Phe Asn Met Ala Arg Thr Asn Phe Val Lys Thr Ile Asn Tyr 
        35                  40                  45              


Ile Met Ser Ile Ala Gly Ile Arg Gly Ser Tyr Ser Glu Ser Gln Ile 
    50                  55                  60                  


Asn Lys Met Leu His Ala Leu Phe Leu Ile Gln Ala Gly Arg Ser Gly 
65                  70                  75                  80  


Glu Leu Thr Lys Glu Gln Arg Gln Trp Glu Lys Lys Leu Arg Leu Asn 
                85                  90                  95      


Thr Glu Gln Gln Thr Arg Leu Gln Lys Leu Leu Phe Lys His Phe Pro 
            100                 105                 110         


Val Leu Gly Pro Met Met Ala Asp Val Ala Asp His Lys Ala Phe Leu 
        115                 120                 125             


Asn Lys Lys Lys Ser Lys Val Gln Thr Glu Glu Asp Lys Phe Ala Gln 
    130                 135                 140                 


Leu Lys Gly Val Ser Leu Ala Asp Cys Leu Asp Val Ile Cys Leu Met 
145                 150                 155                 160 


Ala Asp Ala Leu Thr Glu Cys Arg Asn Phe Tyr Thr His Lys Ala Pro 
                165                 170                 175     


Tyr Asn Ala Pro Ser Gln Leu Ala Ala Gln Tyr Gln His Gln Glu Met 
            180                 185                 190         


Ile Ala Lys Lys Leu Asp Lys Val Val Val Ala Cys Arg Arg Val Leu 
        195                 200                 205             


Lys Asp Arg Glu Gly Leu Ser Val Asn Glu Val Glu Phe Leu Thr Gly 
    210                 215                 220                 


Ile Asp His Leu His Gln Glu Val Val Lys Asp Glu Ser Gly Asn Val 
225                 230                 235                 240 


Lys Lys Lys Asn Gly Lys Val Met Lys Thr Phe Val Asp Tyr Asp Asp 
                245                 250                 255     


Phe Tyr Phe Lys Ile Ser Gly Lys Arg Leu Val Lys Gly Phe Thr Val 
            260                 265                 270         


Ala Val Lys Asp Asp Lys Pro Val Asn Ile Asp Thr Met Leu Pro Ala 
        275                 280                 285             


Leu Ser Asp Phe Gly Leu Leu Tyr Phe Cys Val Leu Phe Leu Ser Lys 
    290                 295                 300                 


Pro Tyr Ala Lys Leu Phe Ile Asp Glu Val Arg Leu Phe Glu Phe Ser 
305                 310                 315                 320 


Pro Phe Thr Asp Thr Glu Asn Met Ile Met Ser Glu Met Leu Ser Ile 
                325                 330                 335     


Tyr Arg Ile Arg Thr Pro Arg Leu His Lys Ile Asp Ser Arg Asp Asn 
            340                 345                 350         


Lys Ala Thr Leu Ala Met Asp Ile Phe Gly Glu Leu Arg Arg Cys Pro 
        355                 360                 365             


Ile Glu Leu Tyr Glu Leu Leu Asp Lys Asn Met Gly Gln Pro Phe Phe 
    370                 375                 380                 


His Asp Glu Val Lys His Pro Asn Ser His Thr Pro Glu Val Ser Lys 
385                 390                 395                 400 


Arg Leu Arg Tyr Asn Asp Arg Phe Pro Thr Leu Ala Leu Arg Tyr Ile 
                405                 410                 415     


Asp Glu Thr Glu Leu Phe Lys Arg Ile Arg Phe Gln Leu Gln Leu Gly 
            420                 425                 430         


Ala Phe Arg Tyr Arg Phe Tyr Asp Lys Glu Asp Cys Ile Asp Gly Ile 
        435                 440                 445             


Val Arg Val Arg Arg Ile Gln Lys Asp Ile Asn Gly Tyr Gly Arg Leu 
    450                 455                 460                 


Gln Glu Val Ala Asp Lys Arg Ile Glu Lys Trp Gly Asp Leu Ile Gln 
465                 470                 475                 480 


Lys Arg Glu Glu His Ala Val Lys Leu Glu His Glu Glu Leu Tyr Ile 
                485                 490                 495     


Asp Leu Asp Gln Phe Val Glu Asp Thr Ala Asp Ser Ile Pro Tyr Val 
            500                 505                 510         


Thr Asp Arg Arg Pro Ser Tyr Asn Ile His Ala Asn Arg Ile Gly Leu 
        515                 520                 525             


Tyr Trp Glu Asp Ser Gln Asn Pro Lys Ser Tyr Lys Ile Phe Asp Glu 
    530                 535                 540                 


Asn Gly Met Tyr Ile Pro Glu Leu Val Val Thr Glu Asp Glu Lys Ala 
545                 550                 555                 560 


Pro Ile Lys Met Pro Ala Pro Arg Cys Thr Leu Ser Val Tyr Asp Leu 
                565                 570                 575     


Ser Ala Met Leu Phe Tyr Glu Tyr Leu His Glu His Gln Asp Val Asp 
            580                 585                 590         


Thr Pro Ser Ala Glu Arg Ile Ile Ile Asp Cys Glu Asp Asp Tyr Arg 
        595                 600                 605             


Arg Phe Phe Lys Ala Val Ala Glu Gly Thr Leu Thr Pro Phe Lys Lys 
    610                 615                 620                 


Thr Lys Glu Phe Arg Glu Tyr Leu Glu Arg Glu Tyr Pro Lys Leu Arg 
625                 630                 635                 640 


Met Ala Asp Ile Pro Glu Lys Leu Gln Leu Tyr Leu Thr Ser Lys Gly 
                645                 650                 655     


Leu Thr His Asp Asn Lys Pro Glu Thr Val His Glu Arg Met Ile Arg 
            660                 665                 670         


Leu Thr Arg Glu His Leu Glu Glu Arg Glu Ile His Val Gln Arg Arg 
        675                 680                 685             


Leu Glu His Tyr Gln Glu Asp Arg Lys Met Ile Gly Glu Lys Glu Asn 
    690                 695                 700                 


Lys Tyr Gly Lys Lys Ser Phe Ala Asp Val Arg His Gly Thr Leu Ala 
705                 710                 715                 720 


Arg Tyr Leu Ala Gln Ser Met Met Glu Trp Gln Pro Thr Lys Leu Lys 
                725                 730                 735     


Asp Lys Glu Lys Gly His Asp Lys Leu Thr Gly Leu Asn Tyr Asn Val 
            740                 745                 750         


Leu Thr Ala Tyr Leu Ala Thr Tyr Gly His Pro Gln Val Ser Glu Asp 
        755                 760                 765             


Asp Phe Val Pro Leu Thr Leu Glu Gln Val Leu Thr Asn Ala His Leu 
    770                 775                 780                 


Leu Gly Gly Asn Asn Pro His Pro Phe Ile Gly Lys Val Leu Ala Leu 
785                 790                 795                 800 


Gly Asn Arg Asn Ile Glu Glu Leu Tyr Leu His Tyr Leu Glu Glu Glu 
                805                 810                 815     


Leu Lys His Ile Arg Ser Arg Lys Gln Ser Leu Leu Ser Asn Pro Ser 
            820                 825                 830         


Asp Lys Ala Leu Ser Ala Leu Pro Phe Val His Tyr Asp Arg Val Arg 
        835                 840                 845             


Phe His Glu Arg Thr Asp Glu Glu Met Arg Ala Leu Ala Ala Arg Tyr 
    850                 855                 860                 


Thr Thr Ile Gln Leu Pro Asp Gly Leu Phe Thr Pro Tyr Ile Leu Glu 
865                 870                 875                 880 


Ile Leu Lys Lys His Tyr Thr Glu Asn Thr Glu Leu Gln Asn Ala Leu 
                885                 890                 895     


Arg Gln Asp Ala Pro Ser Lys Ile Asn Pro Thr Asn Asn Ala Ala Tyr 
            900                 905                 910         


Leu Ile Thr Leu Phe Tyr Lys Thr Val Leu Lys Asp Asp Ala Gln Pro 
        915                 920                 925             


Phe Tyr Ile Ser Gly Lys Ala Tyr Thr Arg Asn Lys Asp Gly Glu Lys 
    930                 935                 940                 


Ala Glu Ala Phe Ser Phe Lys Arg Ser Tyr Glu Leu Phe Ser Val Leu 
945                 950                 955                 960 


Asn Asn Asn Lys Lys Lys Thr Phe Pro Tyr Glu Leu Leu Pro Leu Phe 
                965                 970                 975     


Leu Thr Ser Asp Glu Ile Gln Glu Arg Leu Ser Ala Lys Leu Leu Asp 
            980                 985                 990         


Asp Asn Gly Asn Pro Ile Pro Glu  Ala Gly Lys Arg Gly  Lys Pro Ala 
        995                 1000                 1005             


Thr Asp  Ile Gln Gly Asn Thr  Ile Trp Gln Arg Gln  Ile Lys Gln 
    1010                 1015                 1020             


Lys Ile  Asn Gly Tyr Val Asn  Ser Leu Ser Asp Lys  Asp Leu Lys 
    1025                 1030                 1035             


Ile Ser  Met Asn Gln Ser Trp  Lys Lys Lys Glu Glu  Glu Arg Ala 
    1040                 1045                 1050             


Ala Lys  Arg Glu Ala Met Gln  Ser Arg Leu Thr Lys  Gln Ile Asn 
    1055                 1060                 1065             


Glu Val  Lys Gly Asn Glu Arg  Thr Leu Arg Arg Tyr  Lys Thr Gln 
    1070                 1075                 1080             


Asp Met  Val Ser Phe Leu Met  Ala Lys Glu Leu Phe  Ala Thr Ile 
    1085                 1090                 1095             


Ile Ser  Asp Gln Gly Asn Glu  Val Asn Trp Lys Gln  Met Arg Leu 
    1100                 1105                 1110             


Ser Lys  Val Cys Asn Glu Ala  Phe Leu Arg Gln Thr  Leu Thr Phe 
    1115                 1120                 1125             


Arg Val  Pro Val Thr Val Gly  Asn Thr Thr Ile Tyr  Val Glu Gln 
    1130                 1135                 1140             


Glu Asn  Met Ser Leu Lys Asn  Tyr Gly Glu Phe Tyr  Arg Phe Leu 
    1145                 1150                 1155             


Thr Asp  Asp Arg Leu Met Ser  Leu Leu Asn Asn Ile  Val Glu Thr 
    1160                 1165                 1170             


Leu Lys  Pro Asn Glu Asp Gly  Glu Leu Val Ile Arg  His Thr Asp 
    1175                 1180                 1185             


Leu Met  Ser Glu Leu Ala Ala  Tyr Asp Gln Tyr Arg  Ser Thr Ile 
    1190                 1195                 1200             


Phe Lys  Leu Ile Gln Asn Ile  Glu Asp Leu Ile Ile  Lys Glu Asn 
    1205                 1210                 1215             


Ala Ala  Leu Asn Asp Pro Asp  Ala Asp Gly Phe Trp  Val Arg Lys 
    1220                 1225                 1230             


Asp Leu  Pro Lys Arg Asn Asn  Phe Ala Ser Leu Leu  Glu Leu Leu 
    1235                 1240                 1245             


Asn Gln  Leu Asn Asn Val Asp  Leu Thr Asp Asp Glu  Arg Lys Leu 
    1250                 1255                 1260             


Leu Val  Ala Ile Arg Asn Ala  Phe Ser His Asn Ser  Tyr Asn Ile 
    1265                 1270                 1275             


Asp Phe  Ser Leu Ile Arg Asn  Val Lys His Leu Pro  Glu Val Ala 
    1280                 1285                 1290             


Lys Gly  Ile Leu Gln His Leu  Gln Ser Val Leu Gly  Val Glu Ile 
    1295                 1300                 1305             


Thr Lys  
    1310 


<210>  1638
<211>  1181
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1638

Met Glu Thr Lys Asn Lys Ile Asp Asn Glu Lys Thr Leu Gln Asn Asn 
1               5                   10                  15      


Pro Glu Tyr Phe Gly Ser Tyr Leu Asn Met Ala Arg His Asn Ile Phe 
            20                  25                  30          


Leu Leu Ile Asn His Leu Thr Lys Thr Phe Lys Tyr Leu Pro Phe Glu 
        35                  40                  45              


Leu Leu Lys Asp Asp Glu Asp Ile Ser Lys Val Glu Lys Asn Ile Leu 
    50                  55                  60                  


Leu Asn Val Phe Asp Ile Ser Lys Lys Glu Tyr Glu Asp Glu Arg Gln 
65                  70                  75                  80  


Lys Val Tyr Asn Tyr Leu Ile Lys Arg His His Leu Pro Ile Ile Lys 
                85                  90                  95      


Tyr Leu Gly Lys Ile Glu Gly Asn Asp Leu Val Asp Phe Asp Lys Ile 
            100                 105                 110         


His Gln Phe Ile Thr Ile Ala Phe Gln Glu Val Asn Asn Tyr Arg Asn 
        115                 120                 125             


Asp Tyr Thr His Phe Leu Ala Ile Asp Asp Asn Asn Asn Val Ser Pro 
    130                 135                 140                 


Arg Lys Leu Asp Ile Asp Glu Lys Ile Lys Thr Asp Thr Lys Leu Leu 
145                 150                 155                 160 


Phe Glu Asn Ala Pro Ser Val Ser Tyr Leu Arg Asn Phe Glu Thr Gln 
                165                 170                 175     


Lys Glu Asp Asp Tyr Lys His Ile Leu Ser Asn Tyr Ser Leu Phe Ser 
            180                 185                 190         


Asn Glu Asn Val Phe Thr Glu His Gly Leu Tyr Phe Phe Ile Asn Leu 
        195                 200                 205             


Phe Leu Glu Arg Lys Tyr Ala Ile Lys Leu Leu Lys Lys Ile Arg Gly 
    210                 215                 220                 


Phe Lys Asn Glu Thr Thr Pro Ser Phe Arg Ala Thr Leu Gln Val Phe 
225                 230                 235                 240 


Thr Ser Tyr Cys Ile Lys Leu Pro Asp Thr Arg Leu Gly Asn Glu Phe 
                245                 250                 255     


Pro Lys Gln Thr Ile Leu Met Glu Met Leu Ser Glu Leu Asn Lys Cys 
            260                 265                 270         


Pro Lys Glu Leu Phe Asn His Leu Thr Val Gly Asp Lys Glu Lys Phe 
        275                 280                 285             


Glu Pro Lys Met Asn Glu Glu Gln Lys Ile Asn Ile Leu Leu Asn Ser 
    290                 295                 300                 


Val Asn Tyr Glu Asp Ile Asp Asp Glu Asp Leu Asp Thr Ile Val Lys 
305                 310                 315                 320 


Asp Ile Ile Ser Leu Lys Arg Tyr Glu Asp Arg Phe Pro Asn Phe Ala 
                325                 330                 335     


Leu Arg Phe Leu Glu Glu Thr Asn Ala Phe Glu Gln Ile Arg Phe Gln 
            340                 345                 350         


Ile Thr Leu Gly Lys Leu Val Ile Lys Arg Tyr Asp Lys Thr Ile Asn 
        355                 360                 365             


Gly Ile Glu Gln Asp Arg Arg Val Ile Lys Thr Ile Asn Ala Phe Gly 
    370                 375                 380                 


Lys Leu Ser Asp Phe Ile Gly Lys Glu Asp Glu Ile Leu Lys Leu Ile 
385                 390                 395                 400 


Lys Gln Gly Ile Glu Asp Glu Asn Ile Val Phe Glu Gln Tyr Ser Pro 
                405                 410                 415     


His Tyr Asn Met Asn Asn Asn Lys Ile Gly Phe Lys Ile Phe Asp Glu 
            420                 425                 430         


Glu Ser Glu Lys Leu Gln Leu Pro Phe Val Phe Lys Asn Lys Arg Glu 
        435                 440                 445             


Glu Ser Glu Phe Gln Asn Asn Pro Ser Gly Phe Ile Ser Ile His Asp 
    450                 455                 460                 


Leu His Lys Ile Val Leu Ser Asp Leu Leu Thr Asn Asn Asn His Leu 
465                 470                 475                 480 


Ala Glu Lys Lys Ile Ile Glu Phe Val Asn Asp Ser Asn Ser Lys Ile 
                485                 490                 495     


Phe Asp Ile Ser Ile Leu Asn Glu Ile Lys Glu Lys Val His Tyr Val 
            500                 505                 510         


Pro Glu Ser Phe Thr Lys Arg Asn Phe Asp Lys Lys Lys Met Gln Glu 
        515                 520                 525             


Arg Gly Asp Lys Lys Val His Phe Val Ser Glu Gln Lys Glu Lys Ala 
    530                 535                 540                 


Leu Leu Lys Lys His Lys Leu Ser Arg Glu Gln Leu Leu Ala Met Ser 
545                 550                 555                 560 


Lys Asp Asp Phe Lys Asn Lys Thr Lys Asn Lys Lys Glu Leu Glu Thr 
                565                 570                 575     


Phe Ser Gln Ile Lys Tyr His Asn Tyr Leu Glu Gln Arg Arg Val Glu 
            580                 585                 590         


Leu Gln Lys His Leu Pro Ser Ser Ile Leu Val Asn Gln Leu Pro Glu 
        595                 600                 605             


Arg Leu Ile Asp Tyr Leu Met Asn Ile Thr Glu Val Asp Ser Glu Lys 
    610                 615                 620                 


Arg Ile His Leu Lys Ile Arg Asp Ile Lys Asp Glu Ala Lys Leu Leu 
625                 630                 635                 640 


Leu Lys Glu Ser Lys Ser Glu Pro Glu Glu Gly Gln Ile Ile Lys Leu 
                645                 650                 655     


Gly Glu Tyr Ala Thr Phe Ile Ala Arg Asp Ile Leu Asn Met Ile Ile 
            660                 665                 670         


Asp Lys Asp Val Lys Gln Lys Ile Thr Gln Pro Tyr Tyr Asn Lys Ile 
        675                 680                 685             


Gln Asn Lys Ile Ser Phe Phe Ser Ile Asn Lys Glu Glu Leu Ile Ala 
    690                 695                 700                 


Ile Phe Asn Glu Leu Gln Ile Phe Asp Thr Ile Lys Gly His Val Phe 
705                 710                 715                 720 


Leu Lys Ile Asn His Ile Ser Asn Ser Lys Gly Leu Lys Glu Phe Tyr 
                725                 730                 735     


Thr Thr Tyr Leu Glu Ala Lys Lys Ser Trp Ile Lys Glu Lys Leu Leu 
            740                 745                 750         


Lys Gly Gly Lys Thr Gly Gly Tyr Arg Leu Asn Asn Tyr Gly Val Lys 
        755                 760                 765             


Leu Pro Tyr Ser Phe Thr Ile Ile Lys Ile Gln Cys Glu Glu Phe Asn 
    770                 775                 780                 


Phe Asn Lys Trp Leu Ala Asn Lys Asn Leu Leu Pro Val Asn Ile Pro 
785                 790                 795                 800 


Asn Ser Leu Leu Asp Asn Phe Val Asn Asn Glu Leu Lys Lys Lys Leu 
                805                 810                 815     


Thr Leu Gly Lys Thr Asp Phe Asn Gln Thr Asp Thr Leu Ser Val Leu 
            820                 825                 830         


Leu Arg Lys Met Ile Ile Lys Asp Thr Gln Pro Tyr Tyr Asp Tyr Asp 
        835                 840                 845             


Arg Glu Tyr Asn Leu Asn Lys Lys Ser Ile Leu Val Lys Gly Val Asn 
    850                 855                 860                 


Gly Leu Thr Ser Lys Glu Ile Lys Ser Lys Tyr Asp Lys Asn Val Glu 
865                 870                 875                 880 


Ala Asn Glu Lys Ile Ile Arg Phe Tyr Gln Thr Arg Asp Arg Ile Leu 
                885                 890                 895     


Lys Leu Met Cys Asp Phe Leu Ile Ser Glu Asp Lys Thr Ile Gly Leu 
            900                 905                 910         


Gln Asn Glu Phe Leu Leu Lys Asn Ile Tyr Pro Asn Ser Glu Ile Ser 
        915                 920                 925             


Ile Leu Asp Asn Thr Ala Ser Phe Lys Gln Gln Leu Arg Lys Glu Val 
    930                 935                 940                 


Glu Val Gly Asp Leu Tyr Phe Thr Val Val Ala Glu Asp Thr Glu Lys 
945                 950                 955                 960 


Gln Ile Ala Asn Ile Asn Ala Trp Lys Lys Leu Glu Ala Asn Gln Arg 
                965                 970                 975     


Lys Lys Trp Thr Asp Leu Lys Thr Lys Glu Glu Gln Glu Leu Phe Leu 
            980                 985                 990         


Gln Asn Cys Asn Glu Asp Glu Lys  Leu Ile Tyr His Gly  Gln Lys Gly 
        995                 1000                 1005             


Tyr Gln  Trp Thr Phe Lys Asp  Tyr Gly Arg Phe Lys  Arg Phe Val 
    1010                 1015                 1020             


Lys Asp  Lys Arg Leu Val Asp  Leu Ser Lys Tyr Phe  Glu Thr Thr 
    1025                 1030                 1035             


Ile Ile  Pro Phe Asp Leu Leu  Glu Tyr Gln Ile Met  Glu Tyr Asp 
    1040                 1045                 1050             


Arg Ile  Arg Glu Lys Val Phe  Glu Leu Val Phe Lys  Leu Glu Lys 
    1055                 1060                 1065             


Ala Ile  Phe Glu Lys Asp Ser  Glu Gly Leu Ile Thr  Ile Glu Leu 
    1070                 1075                 1080             


Asn Lys  Arg Pro Lys Asp Phe  Asn Gln Val Gln Phe  Asp Val Tyr 
    1085                 1090                 1095             


Leu Ser  Trp Leu Gln Gln Lys  Asn Ile Ser Phe Ser  Lys Asn Ile 
    1100                 1105                 1110             


Val Lys  Trp Ser Arg Asn Lys  Phe Ser His Thr Glu  Phe Pro Asn 
    1115                 1120                 1125             


Phe Asp  Ser Ile Pro Arg Ile  Thr Asn Glu Gln Ile  Glu Asp Phe 
    1130                 1135                 1140             


Asn Tyr  Tyr Lys Asn Val Phe  Gly Gly Lys Asp His  Ile Asn Ile 
    1145                 1150                 1155             


Ser Ile  Ala Gln Lys Ile Ile  Val Glu Phe Glu Ser  Glu Ile Asn 
    1160                 1165                 1170             


Asn Ile  Ile Ala Gln Ile Asn  Arg 
    1175                 1180     


<210>  1639
<211>  1175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1639

Met Thr Glu Gln Asn Glu Arg Pro Tyr Asn Gly Thr Cys Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Ala His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Tyr Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Glu Lys Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Thr Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Leu Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Glu Glu Ala 
            500                 505                 510         


Ser Ala Glu Lys Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Asp Glu Ile Asn Thr Arg Asp 
    530                 535                 540                 


Glu Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Gly Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Tyr Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Ser Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Asp Leu Glu Ala Trp Ser His Ser Ala Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Val Gly Ile Glu Tyr Ala Ser Arg Glu Asn 
    850                 855                 860                 


Lys Lys Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Lys Ala 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Lys Ala Asp Lys Ile Asn Ile Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Ala Lys Glu His Pro Tyr His Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asp Ile Arg Thr 
945                 950                 955                 960 


Asp Val His Glu Gln Gly Ser Leu Asn Val Leu Asn Arg Val Lys Pro 
                965                 970                 975     


Met Arg Leu Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val 
            980                 985                 990         


His Lys Glu Gln Ala Pro Leu Ala  Thr Val Tyr Ile Glu  Glu Arg Asp 
        995                 1000                 1005             


Thr Lys  Leu Leu Lys Gln Gly  Asn Phe Lys Ser Phe  Val Lys Asp 
    1010                 1015                 1020             


Arg Arg  Leu Asn Gly Leu Phe  Ser Phe Val Asp Thr  Gly Gly Leu 
    1025                 1030                 1035             


Ala Met  Glu Gln Tyr Pro Ile  Ser Lys Leu Arg Val  Glu Tyr Glu 
    1040                 1045                 1050             


Leu Ala  Lys Tyr Gln Thr Ala  Arg Val Cys Ala Phe  Glu Gln Thr 
    1055                 1060                 1065             


Leu Glu  Leu Glu Glu Ser Leu  Leu Thr Arg Tyr Pro  His Leu Pro 
    1070                 1075                 1080             


Asp Lys  Asn Phe Arg Lys Met  Leu Glu Ser Trp Ser  Asp Pro Leu 
    1085                 1090                 1095             


Leu Asp  Lys Trp Pro Asp Leu  His Gly Asn Val Arg  Leu Leu Ile 
    1100                 1105                 1110             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1115                 1120                 1125             


Glu Ala  Val Phe Ser Ser Ile  Arg Lys Tyr Asp Pro  Ser Ser Pro 
    1130                 1135                 1140             


Asp Ala  Ile Glu Glu Arg Met  Gly Leu Asn Ile Ala  His Arg Leu 
    1145                 1150                 1155             


Ser Glu  Glu Val Lys Gln Ala  Lys Glu Met Val Glu  Arg Ile Ile 
    1160                 1165                 1170             


Gln Val  
    1175 


<210>  1640
<211>  1175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1640

Met Thr Glu Gln Asn Glu Arg Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Phe Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Ala His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Cys Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Gly Thr Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Thr Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Leu Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Glu Glu Val 
            500                 505                 510         


Ser Ala Glu Lys Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Gly Glu Ile Asp Thr Leu Asp 
    530                 535                 540                 


Arg Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Gly Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Leu Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Asp Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asn Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Asp Leu Glu Ala Trp Ser His Gly Ala Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Val Gly Ile Glu Tyr Ala Ser Pro Gly Asn 
    850                 855                 860                 


Lys Lys Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Glu Thr 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Lys Ala Asp Lys Ile Asn Ile Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Ala Lys Glu His Pro Tyr Leu Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asp Ile Arg Thr 
945                 950                 955                 960 


Asp Val His Glu Gln Gly Ser Leu Asn Val Leu Asn Arg Val Lys Pro 
                965                 970                 975     


Met Arg Leu Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val 
            980                 985                 990         


His Lys Glu Gln Ala Pro Leu Ala  Thr Val Tyr Ile Glu  Glu Arg Asp 
        995                 1000                 1005             


Thr Lys  Leu Leu Lys Gln Gly  Asn Phe Lys Ser Phe  Val Lys Asp 
    1010                 1015                 1020             


Arg Arg  Leu Asn Gly Leu Phe  Ser Phe Val Asp Thr  Gly Ala Leu 
    1025                 1030                 1035             


Ala Met  Glu Gln Tyr Pro Ile  Ser Lys Leu Arg Val  Glu Tyr Glu 
    1040                 1045                 1050             


Leu Ala  Lys Tyr Gln Thr Ala  Arg Val Cys Ala Phe  Glu Gln Thr 
    1055                 1060                 1065             


Leu Glu  Leu Glu Glu Ser Leu  Leu Thr Arg Tyr Pro  His Leu Pro 
    1070                 1075                 1080             


Asp Lys  Asn Phe Arg Lys Met  Leu Glu Ser Trp Ser  Asp Pro Leu 
    1085                 1090                 1095             


Leu Asp  Lys Trp Pro Asp Leu  His Gly Asn Val Arg  Leu Leu Ile 
    1100                 1105                 1110             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1115                 1120                 1125             


Glu Thr  Leu Phe Ser Ser Ile  Arg Lys Tyr Asp Pro  Ser Ser Pro 
    1130                 1135                 1140             


Asp Ala  Ile Glu Glu Arg Met  Gly Leu Asn Ile Ala  His Arg Leu 
    1145                 1150                 1155             


Ser Glu  Glu Val Lys Gln Ala  Lys Glu Met Ala Glu  Arg Ile Ile 
    1160                 1165                 1170             


Gln Ala  
    1175 


<210>  1641
<211>  1216
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1641

Met Asp Asn Arg Leu Ser Lys Asn Arg Ala Leu Leu Ala Ala Tyr Leu 
1               5                   10                  15      


Asn Met Ala Gln Gln Asn Ile Tyr Ile Thr Leu Leu His Ile Ser Gln 
            20                  25                  30          


Leu Met Gly Val Glu Glu Thr Lys Asp Leu Ser Asn Arg Met Tyr Asp 
        35                  40                  45              


Phe Gln Ile Leu Gln Glu Leu Lys Thr Gly Lys Lys Gly Ala Glu Ser 
    50                  55                  60                  


Glu Gln Met Ile Lys Ser Glu Arg Val Gln Lys Ile Ile Leu Leu Leu 
65                  70                  75                  80  


His Arg His Phe Pro Phe Leu Gln Ala Phe Val Glu Thr Lys His Leu 
                85                  90                  95      


Gln Gln Lys Lys Asn Lys Glu Glu Gly Lys Asn Ala Gln Lys Asn Lys 
            100                 105                 110         


Lys Gly Asn Ala Ile Pro Asn Asn Lys Gly Gln Leu Glu Phe Thr Val 
        115                 120                 125             


Ser Glu Ser Glu Lys Gln Ser Ile Ser Pro Asn Glu Tyr Arg Thr Ile 
    130                 135                 140                 


Leu Cys Asn Thr Phe Arg Leu Ile Asn Asp Leu Arg Asn Glu Tyr Thr 
145                 150                 155                 160 


His Phe Ser Pro Gly Lys Arg Thr Asp Lys Glu Lys Glu Ser His Lys 
                165                 170                 175     


Asn Thr Gln Lys Glu Met Leu Ser Tyr Leu Tyr Leu Cys Leu Asp Gly 
            180                 185                 190         


Gly Arg Arg Val Val Lys Glu Arg Phe Lys Asp Thr Phe Lys Glu Lys 
        195                 200                 205             


Asp Phe Asn Phe Leu Thr Gln Gly Pro Arg Tyr Ser Leu Gln Lys Glu 
    210                 215                 220                 


Arg Gly Lys Thr Lys Ala Glu Glu Arg Pro Asn Phe Tyr Tyr Arg Leu 
225                 230                 235                 240 


Lys Asp Asp Gln Gly Leu Phe Ser Tyr Val Gly Ile Leu Leu Phe Ile 
                245                 250                 255     


Ser Leu Phe Leu His Lys Arg Tyr Ile Ser Glu Met Leu Thr Gln Ser 
            260                 265                 270         


Gly Leu Phe Tyr Thr Pro Arg Tyr Trp Lys Gly Gln Pro Val Asp Val 
        275                 280                 285             


Glu Leu Glu Arg Arg Ile Ile Ser Glu Ile Phe Ser Ile Tyr Arg Ile 
    290                 295                 300                 


Arg Leu Pro Lys Glu Arg Ile Glu Ser Thr Arg Pro Asp Tyr Ala Leu 
305                 310                 315                 320 


Gly Leu Asp Met Leu Asn Glu Leu Gln Lys Cys Pro Asp Glu Leu Tyr 
                325                 330                 335     


Glu Thr Phe Ser Pro Glu Asp Gln Ala Glu Phe Arg Val Lys Arg Glu 
            340                 345                 350         


Tyr Asp Glu Ser Gly Glu Gly Thr Glu Gly Gly Glu Val Leu Leu Lys 
        355                 360                 365             


Arg Phe Asp Asp Arg Phe Pro Tyr Phe Ala Ile Arg Tyr Leu Asp Glu 
    370                 375                 380                 


Asn Leu Val Phe Asp Asp Ile Arg Phe Gln Val Ser Ile Gly Lys Tyr 
385                 390                 395                 400 


Arg Tyr Lys Phe Tyr Asn Lys Leu Cys Ile Asp Val Val Ser Pro His 
                405                 410                 415     


Glu Asp Asp Cys Tyr Arg Leu Arg Ser Leu Gln Lys Asp Ile Asn Gly 
            420                 425                 430         


Phe Gly Arg Leu Asn Glu Val Glu Tyr Glu Arg Met Leu Arg Tyr Gly 
        435                 440                 445             


Ser His Ile His Ala Glu Lys Pro Lys Gly Asp Asp Thr Pro Tyr Leu 
    450                 455                 460                 


Thr Asp His Tyr Thr Ser Tyr Val Phe Asn Gly Asn Arg Ile Gly Leu 
465                 470                 475                 480 


Leu Phe Asn Gln Glu Asn Gly Arg His Asp Leu Glu Glu Thr Arg Gly 
                485                 490                 495     


Thr Arg Leu Tyr Leu Pro Ser Leu Thr Phe Asp Ser Ser Ala Glu Gly 
            500                 505                 510         


Lys Asp Ala His Cys Val Ala Pro Ile Ala Trp Leu Ser Thr Tyr Glu 
        515                 520                 525             


Leu Pro Ala Leu Ile Phe His His Leu Leu Cys His His Tyr Gly Leu 
    530                 535                 540                 


Glu Arg Thr Ala Thr Glu Ala Ile Ile Lys Asp Cys Val Gly Leu Tyr 
545                 550                 555                 560 


His Arg Leu Phe Thr Asp Ile Arg Asp Gly Lys Leu Leu Pro Gly Glu 
                565                 570                 575     


Ala Leu Gly Ile Arg Ala Gly Glu Ser Leu Ser Gln Glu Ile Ser Gln 
            580                 585                 590         


Ile Arg Lys Gly Lys Pro Leu Pro Gln Asn Ile Ser Glu Lys Ile Glu 
        595                 600                 605             


Thr Phe Leu Thr Thr His Tyr Cys Thr Glu Arg Val Cys Leu His Ile 
    610                 615                 620                 


Gln Asp Ile Pro Lys Lys Leu Ile Asp Tyr Leu Ile Gly Lys Arg Leu 
625                 630                 635                 640 


Asp Gln Asp Met Ala Gly Leu Phe Lys Gln Arg Ser Arg Glu Leu Val 
                645                 650                 655     


Asn Lys Met Leu Glu Ser Thr Gln Val Arg Leu Lys Lys Phe Thr Glu 
            660                 665                 670         


Glu Trp Thr Arg Gln Gly Asn Arg Asp Asn Lys Phe Gly Lys Lys Ser 
        675                 680                 685             


Tyr Val Asp Ile Arg Pro Gly Arg Leu Ala Asp Tyr Leu Ala Lys Asp 
    690                 695                 700                 


Leu Leu Phe Phe Gln Pro Tyr Asp Asp Glu Lys Lys Asn Lys Val Thr 
705                 710                 715                 720 


Gly Leu Asn Tyr Gln Val Leu Gln Ala Ala Leu Ala Ile Tyr Asn His 
                725                 730                 735     


Ser Leu Asp Glu Leu Ser Arg Leu Phe Glu Asn Ala Arg Leu Leu Val 
            740                 745                 750         


Pro Glu Gly Pro Lys Met Glu His Pro Phe Leu Arg Ser Val Leu Lys 
        755                 760                 765             


Lys Lys Pro Asn Ser Thr Leu Gln Phe Tyr Ala Tyr Tyr Leu Ile Glu 
    770                 775                 780                 


Lys Ile Lys Tyr Leu Glu Gly Arg Leu Ala Asp Ser Asn Glu Thr Phe 
785                 790                 795                 800 


Ala Asp Leu Phe Arg Tyr Lys Gln Arg Gln Lys Trp Gln Thr Arg Asp 
                805                 810                 815     


Cys Gln Trp Tyr Arg Ala Leu Ala Gly Arg Tyr Met Ala Glu Met Met 
            820                 825                 830         


Glu Glu Gly Thr Met Asn Phe Lys Pro Ile Glu Leu Pro Arg Gly Leu 
        835                 840                 845             


Phe Glu Gln Pro Ile Lys Gln Leu Leu Ala Thr Ile Leu Thr Gln Arg 
    850                 855                 860                 


Thr Gly Ser Asp Ser Gln Ala Leu Leu Lys Ile Val Glu Ser Pro Arg 
865                 870                 875                 880 


Cys Asn Val Ser Tyr Leu Ile Ala Gln Tyr Phe Thr Leu Ile Leu His 
                885                 890                 895     


Asp Asp Ser Gln Pro Phe Tyr Arg Pro Asp Lys Arg Phe Lys Arg Thr 
            900                 905                 910         


Tyr Lys Tyr Phe Asn Ile Leu Asn Asn Arg Lys Glu Arg Asn Lys Leu 
        915                 920                 925             


Val Gln Val Tyr Gln Thr Leu Asp Glu Met Glu Ala Tyr Phe Lys Asp 
    930                 935                 940                 


Thr Glu Ser Leu Glu Lys Gln His Lys Asn Tyr Leu Asn Ser Pro Glu 
945                 950                 955                 960 


Ala Lys Lys His Pro Ala Pro Glu Ala Arg Leu Lys Lys Tyr Leu Ser 
                965                 970                 975     


Glu Tyr Arg Lys Asn Glu Thr Thr Ile Arg Arg Tyr Arg Val Gln Asp 
            980                 985                 990         


Met Leu Ile Phe Leu Met Ala Lys  Ile Leu Leu Leu Glu  Lys Gly Gly 
        995                 1000                 1005             


Leu Lys  Ala Gly Glu Leu Lys  Gln Tyr Lys Leu Ser  Leu Ile Gln 
    1010                 1015                 1020             


Pro Thr  Thr Gly Gln Asn Glu  Arg Gln Asn Ile Leu  Ser Leu Gln 
    1025                 1030                 1035             


Val Pro  Phe Ser Ile Thr Ile  Lys Leu Asn Asp Gly  Thr Glu Arg 
    1040                 1045                 1050             


Thr Ile  Thr Gln Glu Ala Ile  Lys Val Lys Asn Cys  Gly Asp Phe 
    1055                 1060                 1065             


Phe Arg  Phe Leu Tyr Asp Gly  Arg Val Ile Ser Leu  Leu Pro Tyr 
    1070                 1075                 1080             


Thr Gln  Glu Asp Ile Pro Leu  Glu Arg Ser Leu Leu  Asp Lys Glu 
    1085                 1090                 1095             


Leu Glu  Gly Tyr Asp Lys Glu  Arg Ile Pro Ile Phe  Lys Ser Val 
    1100                 1105                 1110             


His Arg  Met Glu Glu Glu Ile  Leu Arg Leu Cys Pro  Glu Leu Asn 
    1115                 1120                 1125             


Asn Pro  Gln Ser Pro Lys Tyr  Lys Tyr Thr Thr Asp  Ile Gly Lys 
    1130                 1135                 1140             


Glu Lys  Ile Val Lys Glu Asn  Phe Arg Ala Met Leu  Thr Glu Leu 
    1145                 1150                 1155             


His Asn  Arg Gly Leu Leu Pro  Glu Asn Glu Ile Glu  Met Met Val 
    1160                 1165                 1170             


Glu Ile  Arg Asn Ser Phe Ala  His Asn Arg Tyr Ala  Ser Val Thr 
    1175                 1180                 1185             


Leu Lys  Gly Lys Glu Ile Pro  Ile Ile Ala Ile Ser  Ile Gln Arg 
    1190                 1195                 1200             


Lys Phe  Asp Gly Val Val Gly  Arg Thr Ile Gly Lys  Lys 
    1205                 1210                 1215     


<210>  1642
<211>  1119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1642

Met Thr Glu Gln Asn Glu Arg Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Phe Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Ala His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Cys His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Cys Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Glu Lys Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Ala Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Ile Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Ala 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Leu Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Asp Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Asp Glu Ile Asn Thr Arg Asp 
    530                 535                 540                 


Glu Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Ser Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly His Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Asp Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Leu Ala Lys Leu Lys Lys Glu Ile Leu Glu Ala 
        835                 840                 845             


Lys Glu His Pro Tyr His Asp Phe Lys Ser Trp Gln Lys Phe Glu Arg 
    850                 855                 860                 


Glu Leu Arg Leu Val Lys Asn Gln Asp Ile Ile Thr Trp Met Met Cys 
865                 870                 875                 880 


Arg Asp Leu Met Glu Glu Asn Lys Val Glu Gly Leu Asp Thr Gly Thr 
                885                 890                 895     


Leu Tyr Leu Lys Asp Ile Arg Thr Asp Val Gln Glu Gln Gly Ser Leu 
            900                 905                 910         


Asn Val Leu Asn Arg Val Lys Pro Met Arg Leu Pro Val Val Val Tyr 
        915                 920                 925             


Arg Ala Asp Ser Arg Gly His Val His Lys Glu Glu Ala Pro Leu Ala 
    930                 935                 940                 


Thr Val Tyr Ile Glu Glu Arg Asp Thr Lys Leu Leu Lys Gln Gly Asn 
945                 950                 955                 960 


Phe Lys Ser Phe Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe 
                965                 970                 975     


Val Asp Thr Gly Ala Leu Ala Met Glu Gln Tyr Pro Ile Ser Lys Leu 
            980                 985                 990         


Arg Val Glu Tyr Glu Leu Ala Lys  Tyr Gln Thr Ala Arg  Val Cys Ala 
        995                 1000                 1005             


Phe Glu  Gln Thr Leu Glu Leu  Glu Glu Ser Leu Leu  Thr Arg Tyr 
    1010                 1015                 1020             


Pro His  Leu Pro Asp Glu Ser  Phe Arg Glu Met Leu  Glu Ser Trp 
    1025                 1030                 1035             


Ser Asp  Pro Leu Leu Asp Lys  Trp Pro Asp Leu His  Arg Lys Val 
    1040                 1045                 1050             


Arg Leu  Leu Ile Ala Val Arg  Asn Ala Phe Ser His  Asn Gln Tyr 
    1055                 1060                 1065             


Pro Met  Tyr Asp Glu Ala Val  Phe Ser Ser Ile Arg  Lys Tyr Asp 
    1070                 1075                 1080             


Pro Ser  Ser Pro Asp Ala Ile  Glu Glu Arg Met Gly  Leu Asn Ile 
    1085                 1090                 1095             


Ala His  Arg Leu Ser Glu Glu  Val Lys Gln Ala Lys  Glu Met Ala 
    1100                 1105                 1110             


Glu Arg  Ile Ile Gln Ala 
    1115                 


<210>  1643
<211>  1175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1643

Met Thr Glu Gln Asn Glu Lys Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Phe Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Ala His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Lys Tyr Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Glu Lys Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Ala Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln Leu Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Phe Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Glu Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Gly Glu Ile Asp Thr Leu Asp 
    530                 535                 540                 


Arg Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Gly Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Leu Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Asp Leu Glu Ala Trp Ser His Ser Ala Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Ala Gly Ile Glu Asn Ala Ser Arg Glu Asn 
    850                 855                 860                 


Lys Lys Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Glu Thr 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Lys Ala Asp Lys Ile Asn Ile Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Ala Lys Glu His Pro Tyr Leu Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asp Ile Arg Thr 
945                 950                 955                 960 


Asp Val Gln Glu Gln Gly Ser Leu Asn Val Leu Asn His Val Lys Pro 
                965                 970                 975     


Met Arg Leu Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val 
            980                 985                 990         


His Lys Glu Gln Ala Pro Leu Ala  Thr Val Tyr Ile Glu  Glu Arg Asp 
        995                 1000                 1005             


Thr Lys  Leu Leu Lys Gln Gly  Asn Phe Lys Ser Phe  Val Lys Asp 
    1010                 1015                 1020             


Arg Arg  Leu Asn Gly Leu Phe  Ser Phe Val Asp Thr  Gly Gly Leu 
    1025                 1030                 1035             


Ala Met  Glu Gln Tyr Pro Ile  Ser Lys Leu Arg Val  Glu Tyr Glu 
    1040                 1045                 1050             


Leu Ala  Lys Tyr Gln Thr Ala  Arg Val Cys Ala Phe  Glu Gln Thr 
    1055                 1060                 1065             


Leu Glu  Leu Glu Glu Ser Leu  Leu Thr Arg Tyr Pro  His Leu Pro 
    1070                 1075                 1080             


Asp Lys  Asn Phe Arg Lys Met  Leu Glu Ser Trp Ser  Asp Pro Leu 
    1085                 1090                 1095             


Leu Asp  Lys Trp Pro Asp Leu  His Arg Lys Val Arg  Leu Leu Ile 
    1100                 1105                 1110             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1115                 1120                 1125             


Glu Ala  Val Phe Ser Ser Ile  Arg Lys Tyr Asp Pro  Ser Ser Pro 
    1130                 1135                 1140             


Asp Ala  Ile Glu Glu Arg Met  Gly Leu Asn Ile Ala  His Arg Leu 
    1145                 1150                 1155             


Ser Glu  Glu Val Lys Gln Ala  Lys Glu Thr Val Glu  Arg Ile Ile 
    1160                 1165                 1170             


Gln Val  
    1175 


<210>  1644
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1644

Met Glu Thr Lys Gln Gln Val Gly Lys Gly Ile Ser Tyr Asp His Arg 
1               5                   10                  15      


Arg Pro Asp Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asp Gly Val Ile Gln Glu Phe Ala Met Arg Leu Asn Arg 
        35                  40                  45              


Glu Tyr Asp Pro Glu Asn Lys Asn Gln Ser Leu Phe Ser Tyr Phe Asn 
    50                  55                  60                  


Ile Asn Ala Ser Phe Thr Asp Trp Glu Arg Gly Val Asn Ile Leu Lys 
65                  70                  75                  80  


Glu Tyr Trp Pro Met Met Glu Phe Ile Asp Arg Pro Ala Thr Asp Lys 
                85                  90                  95      


Gln Phe Glu Ala Glu Lys Pro Glu Asn Arg Glu Ala Ala Lys Arg Lys 
            100                 105                 110         


Tyr Phe Leu Ala Thr Leu Gly Ala Leu Leu Thr Ser Ile Lys Asp Leu 
        115                 120                 125             


Arg His Tyr Tyr Thr His Tyr Tyr His Pro Pro Val His Leu Asn Asp 
    130                 135                 140                 


Asp Leu Phe Leu Phe Leu Asp His Ala Leu Leu Tyr Thr Ala Phe Asp 
145                 150                 155                 160 


Val Lys Lys Thr Lys Met Lys Asp Asp Lys Thr Arg Gln Leu Leu Asn 
                165                 170                 175     


Gln Asn Leu Ser Leu Glu Leu Glu Lys Leu Lys Lys Leu Lys Val Glu 
            180                 185                 190         


Glu Leu Lys Lys Lys Lys Glu Lys Gly Ile Lys Val Asn Leu Gln Asp 
        195                 200                 205             


Glu Lys Gly Ile Leu Asn Ala Ile Tyr Asn Asp Ala Phe Ala His Ile 
    210                 215                 220                 


Ile Thr Lys Glu Lys Asp Ser Asp Lys Asp Lys Leu Glu Thr Arg Tyr 
225                 230                 235                 240 


Lys Ser Ile Leu Pro Gln Asp Glu Ala Ala Glu Thr Gly Ile Asn Ile 
                245                 250                 255     


Ser Ile Ser Gly Leu Ile Phe Leu Leu Ser Leu Phe Leu Ser Arg Lys 
            260                 265                 270         


Glu Ile Glu Gln Leu Lys Ser Asn Ile Glu Gly Tyr Lys Gly Lys Val 
        275                 280                 285             


Leu Asn Ile Glu Thr Glu Val Asp Arg Lys His Asn Ser Leu Lys Tyr 
    290                 295                 300                 


Met Ala Thr His Trp Val Phe Ser Ile Leu Ala Phe Lys Gly Leu Lys 
305                 310                 315                 320 


Gln Arg Leu Thr Asn Ser Phe Glu Lys Glu Ser Leu Leu Ile Gln Met 
                325                 330                 335     


Met Asp Glu Leu Asn Lys Val Pro Asp Glu Leu Tyr Gln Thr Leu Ser 
            340                 345                 350         


Glu Thr Ala Lys Lys Glu Phe Leu Glu Asp Ile Asn Glu Tyr Val Ser 
        355                 360                 365             


Glu Gly Asp Asp Asn Glu Lys Ala Thr Tyr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Ser Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gln Phe Pro Thr Leu Lys Phe Gln Ile Phe Val Gly 
                405                 410                 415     


Gln Tyr Leu His Asp Asn Arg Pro Lys Thr Leu Ala Ser Asn Gly Met 
            420                 425                 430         


Thr Ala Gln Arg Met Ile Lys Glu Lys Ile Asn Leu Phe Gly Asn Leu 
        435                 440                 445             


Ser Glu Val Thr Lys His Lys Ser Asp Phe Phe Glu Lys Glu Ser Ala 
    450                 455                 460                 


Ala Gln Gly Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Trp Ala Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Val Tyr Ile Asp Met Ile Gly Lys Glu Gly Lys Ala 
                485                 490                 495     


Lys Glu Ile Gln Val Gln Ile Asn Lys Tyr Arg Lys Gln Leu Asn Pro 
            500                 505                 510         


Ala Pro Gln Arg Asp Lys Arg Ile Ser Lys Lys Glu Ile Ile Glu Gln 
        515                 520                 525             


Leu Tyr Lys Glu Lys Val Val Tyr Gly Asp Pro Thr Leu Met Leu Ser 
    530                 535                 540                 


Ala Asn Glu Leu Met Ala Leu Leu Tyr Glu Leu Ile Val Asn Gly Lys 
545                 550                 555                 560 


Ser Gly Ala Glu Leu Glu Asn Lys Ile Val Glu Gln Ile Ile Ala Arg 
                565                 570                 575     


Tyr Glu Gln Ile Glu Ala Tyr Asp Pro Thr Thr Gln Gln Leu Pro Thr 
            580                 585                 590         


Asn Gln Met Pro His Lys Leu Gln Lys Ser Arg Lys Asp Ser Lys Val 
        595                 600                 605             


Thr Asp Thr Asp Lys Leu Leu Lys Thr Ile Asp Lys Glu Ile Asp Glu 
    610                 615                 620                 


Gly Asn Lys Lys Leu Glu Leu Ile Ala Cys His Arg Lys Glu Trp Glu 
625                 630                 635                 640 


Glu Ala Glu Gln Arg Lys Lys Ser Gly Lys Arg Asn Asn Pro Gly Thr 
                645                 650                 655     


Lys Ser Arg Lys His Leu Phe Tyr Ala Ser Glu Met Gly Glu Glu Ala 
            660                 665                 670         


Thr Trp Ile Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Pro Ala Arg 
        675                 680                 685             


Ala Glu Trp Lys Gly Thr His His Ser Glu Leu Gln Arg Leu Leu Ala 
    690                 695                 700                 


Phe Tyr Ser Thr Gln Arg Leu Glu Ala Trp Gln Leu Val Glu Ser Val 
705                 710                 715                 720 


Trp Thr Ala Asn Thr His Ser Phe Trp Glu Glu Asn Phe Lys Glu Ala 
                725                 730                 735     


Phe Tyr Lys Pro Glu Phe Glu Asn Phe Tyr Gly Ala Tyr Ile Glu Ile 
            740                 745                 750         


Arg Thr Lys Ile Leu Thr Thr Cys Arg Ser Ile Leu Glu Asn Asn Pro 
        755                 760                 765             


Glu Ala Thr Met Asn Asn Asp Thr Glu Lys Glu Trp Asp Lys Val Phe 
    770                 775                 780                 


Thr Leu Phe Asp Lys Arg Leu Tyr Arg Thr Ser Thr Thr Asp Glu Gln 
785                 790                 795                 800 


Lys Lys Gln Leu Leu Thr Lys Pro Phe Ala Phe Pro Arg Gly Leu Phe 
                805                 810                 815     


Asp Asp Lys Pro Thr Phe Leu Pro Gly Ser Lys Pro Asn Glu Asn Pro 
            820                 825                 830         


Glu Arg Phe Ala Ala Trp Tyr Ser Tyr Gly Tyr Thr Tyr Ser Gly Lys 
        835                 840                 845             


Phe Gln Ser Phe Tyr Asp Met Pro Arg Asn Tyr Ser Asp Trp Tyr Lys 
    850                 855                 860                 


Lys Leu Lys Glu Asp Gly Lys Leu Pro Arg Leu Asp Lys Lys Thr Glu 
865                 870                 875                 880 


Gln Glu Lys Ile Leu Arg Phe Arg Met Asp Cys Asp Leu Asn Ile Lys 
                885                 890                 895     


His Ile Arg Phe Gln Asp Ile Tyr Val Lys Leu Met Val Asp Ser Leu 
            900                 905                 910         


Tyr Lys Ala Val Phe Gly Gln Gln Pro Glu Phe Asp Leu Ser His Leu 
        915                 920                 925             


Tyr Asp Thr Arg Ser Glu Arg Tyr Glu Asn Asn Thr Ile Ala Gln Arg 
    930                 935                 940                 


Gln Lys Ser Arg Gln Glu Gly Asp Asn Ser Asp Asn Ala Ile Asn Glu 
945                 950                 955                 960 


Asn Tyr Val Trp Asn Lys Thr Phe Ala Ile Ser Leu Tyr Asn Gly Arg 
                965                 970                 975     


Ile Thr Glu Ser Gln Val Lys Leu Lys Asp Val Gly Lys Phe Arg Arg 
            980                 985                 990         


Phe Ala Thr Asp Pro Arg Val Gln  Thr Leu Ile Ser Tyr  Asp Asp Thr 
        995                 1000                 1005             


Arg Thr  Trp Thr Lys Leu Glu  Ile Glu Asn Glu Leu  Asp Asn Lys 
    1010                 1015                 1020             


Ala Asp  Ala Tyr Glu Pro Ile  Arg Arg Thr Gln Ser  Leu Lys Ala 
    1025                 1030                 1035             


Ile Gln  Gln Leu Glu Lys Asn  Ile Leu Lys Lys Asn  Gly Phe Asn 
    1040                 1045                 1050             


Gly Lys  Gln His Pro Glu Glu  Leu Lys His Asn Gly  Asn Pro Asn 
    1055                 1060                 1065             


Phe Arg  Lys Tyr Ile Ala Asn  Gly Leu Leu Lys His  Arg Thr Asp 
    1070                 1075                 1080             


Ile Arg  Gln Glu Glu Leu Ala  Leu Ile Ser Asp Thr  Glu Phe Gln 
    1085                 1090                 1095             


Glu Ile  Gly Leu Glu Arg Ile  Arg Gln Thr Asn Pro  Leu Ile Gln 
    1100                 1105                 1110             


Lys Ala  Tyr Leu Leu Ile Leu  Leu Arg Asn Lys Phe  Gly His Asn 
    1115                 1120                 1125             


Gln Leu  Pro Asp Gln Glu His  Phe Arg Leu Met Arg  Ser Ile Tyr 
    1130                 1135                 1140             


Pro Tyr  Asn Gln Gln Glu Ser  Tyr Ser Ala Tyr Phe  Asn His Val 
    1145                 1150                 1155             


Ile Thr  Gln Ile Ile Glu Glu  Leu Asn Thr 
    1160                 1165             


<210>  1645
<211>  1265
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1645

Met Thr Asn Asn Arg Asn Asn Lys Gly Gly Asn Ser Ala Tyr Arg Asn 
1               5                   10                  15      


Asn Lys Ser Asn Pro Asp Tyr Glu Lys Leu Ile Pro Val Pro Phe Leu 
            20                  25                  30          


Ala Asn Asp Lys Pro Val Trp Ala Asn Tyr Leu Asn Met Ala Arg Gln 
        35                  40                  45              


Asn Ile Tyr Ile Thr Leu Cys His Ile Thr Arg Val Leu Gly Leu Pro 
    50                  55                  60                  


Leu Thr Glu Ser Ser Asn Leu Glu Ala Thr Leu Met Gln Ile Pro Val 
65                  70                  75                  80  


Ile Thr Leu Leu Asn Lys Asp Asn Gly Lys Ala Glu Gln Lys Glu Lys 
                85                  90                  95      


Ala Ile Arg Met Leu Asp Lys His Phe Pro Phe Leu Thr Pro Met Val 
            100                 105                 110         


Glu Lys Tyr Ile Met Leu Thr Cys Lys Asp Arg Gln Ser Lys Asp Lys 
        115                 120                 125             


Thr Pro Lys Val Tyr Tyr Glu Val Phe Ser Ile Ile Leu Pro Leu Ile 
    130                 135                 140                 


Asn Leu Leu Arg Asn Lys Tyr Thr His Tyr Arg Leu Glu Asp Lys Met 
145                 150                 155                 160 


Leu Asp Asn Lys Glu Asn Ile Ile Asp Lys Ser Ile Leu Lys Asn Met 
                165                 170                 175     


Ala Ile Leu Ser Gln Leu Leu Ser Tyr Cys Phe Val Gly Ala Thr Arg 
            180                 185                 190         


Ile Thr Lys Glu Arg Phe Gly Ala Lys Ser Asn Ala Glu Gly Gly Thr 
        195                 200                 205             


Leu Asn Glu Arg Asp Phe Tyr Phe Leu Asn Gly Leu Thr Pro Arg Glu 
    210                 215                 220                 


Asn Pro Trp Arg Tyr Tyr Gln Ala Tyr Lys Lys Asp Lys Glu Gly Asn 
225                 230                 235                 240 


Thr Ile Lys Thr Arg Lys Pro Asn Gly Gln Glu Ile Ala Thr Lys Met 
                245                 250                 255     


Thr Tyr Glu Arg Ala Asp Phe Lys Tyr Ala Ile Tyr Asn Leu Lys Asp 
            260                 265                 270         


Ala Asn Gly Met Pro Leu Lys Glu Arg Arg Leu Thr Asn Val Gly Leu 
        275                 280                 285             


Leu Met Leu Val Cys Leu Phe Leu Glu Lys Arg Tyr Ala Ser Glu Phe 
    290                 295                 300                 


Ala Asp Gln Thr Glu Phe Phe Thr Arg Arg Asn Thr Lys Thr Tyr Lys 
305                 310                 315                 320 


Pro Glu Gln Ser Glu Val Thr Ile Met Arg Glu Ile Ile Ser Val Tyr 
                325                 330                 335     


Arg Met Arg Leu Pro Lys Glu Arg Met Gln Ser Thr Arg Asp Asn Ser 
            340                 345                 350         


Ala Leu Gly Leu Asp Met Leu Asn Glu Leu Lys Lys Cys Pro Arg Pro 
        355                 360                 365             


Leu Phe Asp Thr Leu Ser Pro Ala Asp Gln Asn Leu Phe Arg Val Ala 
    370                 375                 380                 


Val Thr Glu Asn Glu Asn Thr Gln Asn Asp Glu Thr Ile Glu Asn Gly 
385                 390                 395                 400 


Met Met Leu Met Leu Arg Arg Thr Asp Arg Phe Pro Ser Leu Ala Leu 
                405                 410                 415     


Arg Phe Ile Asp Thr Asn Gln Val Phe Lys Ser Ile Arg Phe Gln Val 
            420                 425                 430         


His Leu Gly Asn Tyr Arg Tyr Lys Phe Tyr Glu Lys Lys Trp Ile Asp 
        435                 440                 445             


Gly Asn Asp Gly Lys Asp Arg Val Arg Ile Leu Gln Lys Glu Leu Asn 
    450                 455                 460                 


Gly Phe Gly Arg Leu Asp Glu Ile Glu Val Thr Arg Asn Asn Lys Trp 
465                 470                 475                 480 


Gly Asp Leu Ile Arg Lys Ile Asp Gln Pro Arg Glu Asp Thr Phe Glu 
                485                 490                 495     


Thr Ala Pro Tyr Val Thr Asp His His Ala Thr Tyr Leu Phe Asn Asn 
            500                 505                 510         


Asn Arg Ile Gly Leu Leu Trp Asn Thr Gln Asp His Ile Ala Leu Ser 
        515                 520                 525             


Asn Gly Ile Tyr Leu Pro Ser Leu Leu Glu Lys Asn Arg Ile Leu Ser 
    530                 535                 540                 


Glu Asp Glu Lys Leu Lys Asp Leu Lys Asp Gln His Gly Asn Gly Ile 
545                 550                 555                 560 


Ala Glu Cys Val Glu Pro Met Cys Trp Leu Ser Val Tyr Asp Ile Pro 
                565                 570                 575     


Ala Ala Ile Phe Leu Ile His Leu Leu His Lys Asn Gly Gln Thr Phe 
            580                 585                 590         


Glu Ser Ala Gly Lys Thr Val Glu Asp Ile Ile Lys Ala Thr Tyr Asn 
        595                 600                 605             


Asn Tyr Gln Gln Phe Leu Lys Gly Ile Ala Gly Gly Thr Ile Thr Ser 
    610                 615                 620                 


Met Asp Asp Leu Gln Thr Gln Gly Ile Gly Ile Lys Pro Cys Asp Ile 
625                 630                 635                 640 


Pro Val Lys Leu Arg Glu Tyr Leu Asn Gly Lys Gln Thr Asn Ile Lys 
                645                 650                 655     


Glu Asp Phe Val Tyr Leu Gly Tyr Glu Arg Leu Leu Asp Met Tyr Glu 
            660                 665                 670         


Arg Asn Glu Lys Arg Leu Glu Arg Phe Gln Arg Asp Asn Asp Thr Tyr 
        675                 680                 685             


Gly Ser Lys Glu Asn Lys Ile Gly Lys Lys Ala Tyr Ile Asp Ile Arg 
    690                 695                 700                 


Pro Gly Thr Leu Ala Arg His Ile Ala Asp Asp Ile Met Phe Phe Val 
705                 710                 715                 720 


Pro Thr Asp Lys Asn Asn Asn Lys Val Arg Ile Thr Gly Gln Asn Phe 
                725                 730                 735     


Asn Ile Met Gln Ala Ala Ile Ala Gln Tyr Thr Gly Asn Ile Val Gln 
            740                 745                 750         


Leu Arg Thr Leu Leu Gln Lys Gly Glu Ile Ile Asn Cys Glu Arg Gln 
        755                 760                 765             


His Pro Phe Met His Lys Val Leu Ala Thr Lys Pro Cys Ser Phe Ala 
    770                 775                 780                 


Ala Leu Tyr Thr Ala Tyr Leu Lys Ala Lys Arg Ala Tyr Leu Ala Asn 
785                 790                 795                 800 


Leu Ile Lys Glu Tyr Gln Lys Ala Arg Lys Lys Thr Asn Asp Ile Lys 
                805                 810                 815     


Thr Leu Lys Lys Gln Phe Val Lys Asp Tyr Ser Lys Leu Ala Ala Leu 
            820                 825                 830         


Ser Phe Leu His Val Asp Arg Gln Lys Trp Ala Glu Arg Asn Glu Asp 
        835                 840                 845             


Tyr Tyr Lys Gln Leu Ala Glu Arg Tyr Ala Thr Ile Glu Leu Pro His 
    850                 855                 860                 


Gly Ile Phe Leu Asn Ala Ile His Asp Ala Ile Met Gln Leu Pro Glu 
865                 870                 875                 880 


Ser Lys Asn Met Asp Ile Asp Lys Glu Lys Asp Asn Val Ser Gly Leu 
                885                 890                 895     


Ile Leu Lys Tyr Phe Lys Ala Ser Gly Asp Ala Ser Gln Pro Phe Tyr 
            900                 905                 910         


Gly Asn Lys Phe Lys Arg Asn Tyr Lys Tyr Leu Asp Met Met Val Lys 
        915                 920                 925             


Pro Glu Trp Ser Tyr Ser Gly Pro Gln Pro Ser Leu Glu Lys His Tyr 
    930                 935                 940                 


Tyr Ser Ile Ser Glu Met Ala Asn Met Gln Lys Gln Trp Gly Gln Thr 
945                 950                 955                 960 


Lys Glu Leu Arg Glu Lys Arg Val Ala Val Tyr Ala Lys Ala Val Asp 
                965                 970                 975     


Lys Lys Thr Asn His Leu Leu Glu Lys Ala Arg Ala Lys Phe Gly Asn 
            980                 985                 990         


Asp Ile Arg Lys Leu Glu Arg Arg  Glu Lys Ser Ile Gln  Arg Glu Cys 
        995                 1000                 1005             


Asn Glu  Glu Lys Lys Ala Ala  Ile Glu Lys Leu Gln  His Cys Arg 
    1010                 1015                 1020             


Thr Ser  Tyr Ser Ala Asn Glu  Arg Glu Ile Arg Arg  Tyr Lys Val 
    1025                 1030                 1035             


Gln Asp  Ile Leu Ile Phe Leu  Met Ala Ile Asp His  Leu Thr Ala 
    1040                 1045                 1050             


Ala Met  Gly Thr Lys Gly Asn  Phe Ser Ser Tyr Lys  Leu Arg Asn 
    1055                 1060                 1065             


Ile Gly  Cys Ala Ser Glu Ser  Ser Asp Ile Leu Ser  Met Leu Met 
    1070                 1075                 1080             


Pro Phe  Ser Met Thr Leu Glu  Ile Pro Ser Leu Ile  Lys Asp Glu 
    1085                 1090                 1095             


Pro Ala  Lys Val Ile Thr Ile  Lys Gln Asp Asp Leu  Lys Leu Lys 
    1100                 1105                 1110             


Asn Tyr  Gly Asp Phe Phe Arg  Phe Ile Tyr Asp Arg  Arg Ile Arg 
    1115                 1120                 1125             


Thr Leu  Leu Gln Asn Val Lys  Glu Asn Glu Phe Thr  Arg Gln Gln 
    1130                 1135                 1140             


Ile Glu  Glu Glu Leu Glu Cys  Tyr Asn Arg Met Arg  Ile Pro Val 
    1145                 1150                 1155             


Phe Lys  Gln Val Leu Ser Thr  Glu Glu Lys Ile Trp  Lys Gln Leu 
    1160                 1165                 1170             


Pro Ser  Glu Gln Leu His Lys  Lys Ala Asp Asp Lys  Glu His Pro 
    1175                 1180                 1185             


Val Asn  Ile Asp Phe Lys Tyr  Leu Met Gln Phe Val  Asn Ile Lys 
    1190                 1195                 1200             


Glu Ser  Asn Ile Glu Ile Ile  Lys Ala Ile Arg Asn  Ala Phe Ser 
    1205                 1210                 1215             


His Asn  Gln Tyr Pro Thr Asp  Ser Ala Val Ala Arg  Leu Val Phe 
    1220                 1225                 1230             


Asp Lys  Lys Gln Ile Pro Glu  Leu Ala Lys Glu Ile  Thr Lys Leu 
    1235                 1240                 1245             


Leu His  Asn Lys Thr Asn Gln  Ile Asn Leu Lys Asp  Met Glu Asp 
    1250                 1255                 1260             


Lys Gln  
    1265 


<210>  1646
<211>  1146
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1646

Met Glu Ser Ile Ile Gly Leu Gly Leu Ser Phe Asn Pro Tyr Lys Thr 
1               5                   10                  15      


Ala Asp Lys His Tyr Phe Gly Ser Phe Leu Asn Leu Ala Asp Asn Asn 
            20                  25                  30          


Leu Lys Ala Val Phe Ala Glu Phe Lys Glu Arg Ile Ser Asp Lys Ser 
        35                  40                  45              


Lys Asp Glu Asp Ile Ser Asn Leu Ile Glu Lys His Phe Ile Asp Asn 
    50                  55                  60                  


Met Ser Ile Val Asp Tyr Glu Lys Asn Ile Ser Ile Leu Asn Gly Tyr 
65                  70                  75                  80  


Leu Pro Ile Ile Asp Phe Leu Asp Asp Glu Leu Glu Asn Asn Leu Asn 
                85                  90                  95      


Thr Arg Val Lys Asn Phe Lys Lys Ser Phe Ile Ile Leu Ala Glu Ala 
            100                 105                 110         


Leu Glu Thr Leu Arg Asn Tyr Tyr Thr His Phe Tyr His Asp Pro Ile 
        115                 120                 125             


Thr Phe Gly Asp Asn Lys Glu Pro Leu Leu Glu Leu Leu Asp Glu Val 
    130                 135                 140                 


Leu Leu Lys Thr Ile Leu Asp Val Lys Lys Lys Tyr Leu Lys Thr Asp 
145                 150                 155                 160 


Lys Thr Lys Glu Ile Leu Lys Asp Ser Leu Arg Glu Glu Met Asp Leu 
                165                 170                 175     


Leu Val Ile Arg Lys Thr Asp Glu Leu Arg Glu Lys Lys Lys Thr Asn 
            180                 185                 190         


Pro Lys Phe Lys Phe Ser Thr Asp Pro Thr Gln Ile Arg Asn Ser Ile 
        195                 200                 205             


Phe Asn Asp Ala Phe Gln Gly Leu Leu Tyr Glu Asp Lys Glu Asn Asn 
    210                 215                 220                 


Gly Lys Thr Gln Val Ser Tyr Arg Ala Lys Thr Lys Leu Asn Pro Lys 
225                 230                 235                 240 


Asp Ile His Lys Gln Glu Glu Arg Asp Phe Glu Ile Pro Leu Ser Thr 
                245                 250                 255     


Ser Gly Ile Val Phe Leu Met Ser Leu Phe Leu Ser Lys Lys Glu Ile 
            260                 265                 270         


Glu Asp Phe Lys Ser Asn Ile Lys Gly Phe Lys Gly Lys Val Val Lys 
        275                 280                 285             


Asp Glu Asn His Asn Ser Leu Lys Tyr Met Ala Thr His Arg Val Tyr 
    290                 295                 300                 


Ser Ile Leu Ala Phe Lys Gly Leu Lys Tyr Arg Ile Lys Thr Asp Thr 
305                 310                 315                 320 


Phe Ser Lys Val Thr Leu Met Met Gln Met Ile Asp Glu Leu Ser Lys 
                325                 330                 335     


Val Pro Asp Cys Val Tyr Gln Asn Leu Ser Glu Thr Lys Gln Lys Asp 
            340                 345                 350         


Phe Ile Glu Asp Trp Asn Glu Tyr Leu Lys Asp Asn Glu Glu Asn Thr 
        355                 360                 365             


Glu Asn Leu Glu Asn Ser Arg Val Val His Pro Leu Ile Arg Lys Arg 
    370                 375                 380                 


Tyr Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe 
385                 390                 395                 400 


Ala Asn Phe Lys Thr Leu Lys Phe Gln Val Phe Met Gly Tyr Tyr Ile 
                405                 410                 415     


His Asp Gln Arg Thr Lys Thr Ile Gly Thr Thr Asn Ile Thr Thr Glu 
            420                 425                 430         


Arg Thr Val Lys Glu Lys Ile Asn Val Phe Gly Lys Leu Ser Lys Met 
        435                 440                 445             


Asp Asn Leu Lys Lys His Phe Phe Ser Gln Leu Ser Asp Glu Glu Asn 
    450                 455                 460                 


Thr Asp Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Phe Leu Thr Gln 
465                 470                 475                 480 


Ala Asp Asn Ser Pro Ala Asn Asn Ile Pro Ile Tyr Leu Glu Leu Lys 
                485                 490                 495     


Asn Gln Gln Ile Ile Lys Glu Lys Asp Asp Ile Lys Ala Glu Val Asn 
            500                 505                 510         


Asn Ser Gln Asn Arg Asn Pro Asn Lys Pro Ser Lys Arg Asp Leu Leu 
        515                 520                 525             


Asn Lys Ile Ser Asn Thr Asn Glu Asp Phe Tyr Gln Gly Asp Pro Thr 
    530                 535                 540                 


Ala Ile Leu Ser Leu Asn Glu Ile Pro Ala Leu Leu His Leu Phe Leu 
545                 550                 555                 560 


Val Gln Pro Asp Asn Lys Thr Gly Gln Gln Ile Glu Asn Ile Ile Arg 
                565                 570                 575     


Ile Lys Ile Glu Lys Gln Phe Asn Ser Ile Lys Asn Pro Ser Lys Asp 
            580                 585                 590         


Asp Lys Gly Val Pro Lys Ser Leu Phe Ala Asp Thr Asn Val Arg Val 
        595                 600                 605             


Asn Ala Ile Lys Leu Lys Lys Asp Leu Gly Glu Glu Leu Asp Met Leu 
    610                 615                 620                 


Asn Lys Lys Gln Ile Val Phe Lys Glu Asn Gln Lys Ala Ser Ser Asn 
625                 630                 635                 640 


Tyr Asp Glu Leu Leu Lys Lys His Gln Phe Thr Pro Lys Asn Lys Arg 
                645                 650                 655     


Pro Ala Leu Arg Lys Tyr Val Phe Tyr Asn Ser Glu Lys Gly Glu Glu 
            660                 665                 670         


Ala Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Lys Gly Phe 
        675                 680                 685             


Lys Thr Lys Trp Lys Gly Tyr Gln His Ser Glu Leu Gln Arg Lys Leu 
    690                 695                 700                 


Ala Phe Tyr Asp Arg His Thr Lys Gln Asp Ile Lys Glu Leu Leu Ser 
705                 710                 715                 720 


Gly Cys Glu Phe Asp His Phe Leu Leu Asp Ile Asn Ala Cys Phe Lys 
                725                 730                 735     


Glu Asp Asp Phe Glu Asp Phe Phe Ser Lys Tyr Leu Lys Asn Arg Ile 
            740                 745                 750         


Glu Thr Leu Asn Ile Ile Leu Lys Gln Leu His Asp Phe Lys Asn Glu 
        755                 760                 765             


Pro Thr Pro Leu Lys Gly Val Phe Lys Asn Cys Leu Lys Phe Leu Lys 
    770                 775                 780                 


Gln Lys Asn Tyr Val Thr Glu Asn Pro Glu Ile Ile Lys Lys Arg Ile 
785                 790                 795                 800 


Leu Ala Lys Pro Ala Phe Leu Pro Arg Gly Ile Phe Asp Glu Arg Pro 
                805                 810                 815     


Thr Met Lys Lys Gly Lys Asn Pro Leu Ile Asp Arg Asp Glu Phe Ala 
            820                 825                 830         


Lys Trp Phe Val Glu Tyr Leu Glu Asn Lys Asp Tyr Gln Lys Phe Tyr 
        835                 840                 845             


Asn Ser Glu Glu Tyr Arg Ile Arg Asp Ala Asp Phe Lys Lys Asn Ala 
    850                 855                 860                 


Val Ile Lys Lys Gln Lys Leu Lys Asp Phe Tyr Thr Leu Gln Met Val 
865                 870                 875                 880 


Asn Tyr Leu Leu Lys Glu Val Phe Gly Lys Asp Glu Met Asn Leu Gln 
                885                 890                 895     


Leu Ser Glu Leu Phe Gln Thr Arg Gln Glu Arg Leu Lys Leu Gln Gly 
            900                 905                 910         


Ile Ala Lys Lys Gln Met Asn Lys Glu Thr Gly Asp Ser Ser Glu Asn 
        915                 920                 925             


Thr Arg Asn Gln Thr Tyr Ile Trp Asn Lys Asp Val Pro Val Ser Phe 
    930                 935                 940                 


Phe Asn Gly Lys Val Thr Ile Asp Lys Val Lys Leu Lys Asn Ile Gly 
945                 950                 955                 960 


Lys Tyr Lys Arg Tyr Glu Arg Asp Glu Arg Val Lys Thr Phe Ile Gly 
                965                 970                 975     


Tyr Glu Val Asp Glu Lys Trp Met Met Tyr Leu Pro His Asn Trp Lys 
            980                 985                 990         


Asp Arg Tyr Ser Val Lys Pro Ile  Asn Val Ile Asp Leu  Gln Ile Gln 
        995                 1000                 1005             


Glu Tyr  Glu Glu Ile Arg Ser  His Glu Leu Leu Lys  Glu Ile Gln 
    1010                 1015                 1020             


Asn Leu  Glu Gln Tyr Ile Tyr  Asp His Thr Thr Asp  Lys Asn Thr 
    1025                 1030                 1035             


Leu Leu  Gln Asp Gly Asn Pro  Asn Phe Lys Met Tyr  Val Leu Asn 
    1040                 1045                 1050             


Gly Leu  Leu Thr Gly Ile Lys  Gln Val Asn Ile Ala  Asp Phe Ile 
    1055                 1060                 1065             


Val Leu  Lys Gln Asn Thr Asn  Phe Asp Lys Ile Asp  Phe Thr Gly 
    1070                 1075                 1080             


Ile Ala  Ser Cys Ser Glu Leu  Glu Lys Lys Thr Ile  Ile Leu Ile 
    1085                 1090                 1095             


Ala Ile  Arg Asn Lys Phe Ala  His Asn Gln Leu Pro  Asn Lys Thr 
    1100                 1105                 1110             


Ile Tyr  Asp Leu Ala Asn Glu  Phe Leu Lys Lys Glu  Lys Arg Glu 
    1115                 1120                 1125             


Thr Tyr  Ala Asn Tyr Tyr Leu  Lys Val Leu Lys Lys  Met Ile Ser 
    1130                 1135                 1140             


Asp Leu  Ala 
    1145     


<210>  1647
<211>  1119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1647

Met Thr Glu Gln Asn Glu Arg Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Phe Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Thr His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Tyr Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Glu Lys Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Ala Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Cys Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Ala 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Leu Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Asp Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Asp Glu Ile Asn Thr Arg Asp 
    530                 535                 540                 


Glu Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Gly Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Gly Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Leu Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Trp Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asn Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Leu Ala Lys Leu Lys Lys Glu Ile Leu Glu Ala 
        835                 840                 845             


Lys Glu His Pro Tyr Leu Asp Phe Lys Ser Trp Gln Lys Phe Glu Arg 
    850                 855                 860                 


Glu Leu Arg Leu Val Lys Asn Gln Asp Ile Ile Thr Trp Met Ile Cys 
865                 870                 875                 880 


Arg Asp Leu Met Glu Glu Asn Lys Val Glu Gly Leu Asp Thr Gly Thr 
                885                 890                 895     


Leu Tyr Leu Lys Asp Ile Arg Thr Asp Val Gln Glu Gln Gly Ser Leu 
            900                 905                 910         


Asn Val Leu Asn Arg Val Lys Pro Met Arg Leu Pro Val Val Val Tyr 
        915                 920                 925             


Arg Ala Asp Ser Arg Gly His Val His Lys Glu Gln Ala Pro Leu Ala 
    930                 935                 940                 


Thr Val Tyr Ile Glu Glu Arg Asp Thr Lys Leu Leu Lys Gln Gly Asn 
945                 950                 955                 960 


Phe Lys Ser Phe Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe 
                965                 970                 975     


Val Asp Thr Gly Ala Leu Ala Met Glu Gln Tyr Pro Ile Ser Lys Leu 
            980                 985                 990         


Arg Val Glu Tyr Glu Leu Ala Lys  Tyr Gln Thr Ala Arg  Val Cys Ala 
        995                 1000                 1005             


Phe Glu  Gln Thr Leu Glu Leu  Glu Glu Ser Leu Leu  Thr Arg Cys 
    1010                 1015                 1020             


Pro His  Leu Pro Asp Lys Asn  Phe Arg Lys Met Leu  Glu Ser Trp 
    1025                 1030                 1035             


Ser Asp  Pro Leu Leu Asp Lys  Trp Pro Asp Leu His  Arg Lys Val 
    1040                 1045                 1050             


Arg Leu  Leu Ile Ala Val Arg  Asn Ala Phe Ser His  Asn Gln Tyr 
    1055                 1060                 1065             


Pro Met  Tyr Asp Glu Ala Val  Phe Ser Ser Ile Arg  Lys Tyr Asp 
    1070                 1075                 1080             


Pro Ser  Phe Pro Asp Ala Ile  Glu Glu Arg Met Gly  Leu Asn Ile 
    1085                 1090                 1095             


Ala His  Arg Leu Ser Glu Glu  Val Lys Gln Ala Lys  Glu Thr Val 
    1100                 1105                 1110             


Glu Arg  Ile Ile Gln Ala 
    1115                 


<210>  1648
<211>  1171
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1648

Met Ala Leu Lys Gln Trp Arg Gln Ser Lys Thr Pro Asn Leu Lys Pro 
1               5                   10                  15      


Val Phe Ser Ala Tyr Leu Asn Met Ala Arg His Asn Cys Tyr Lys Ser 
            20                  25                  30          


Leu Leu His Val Ser Lys Leu Met Gln Ile Ser Glu Ser Asn Glu Glu 
        35                  40                  45              


Glu Asn Ile Thr Met Phe Ser Leu Trp Asp Lys Leu Val Lys Gly Thr 
    50                  55                  60                  


Pro Thr Glu Lys Leu Lys Ile Ile Gln Leu Leu Gln Lys His Phe Pro 
65                  70                  75                  80  


Met Met Gln Gly Ile Phe Asp Ile Glu Lys Arg Thr Asn Ile Ser Ile 
                85                  90                  95      


Ala Thr Asn Pro Lys Glu Ile Lys Arg Thr Leu His Ala Phe Phe His 
            100                 105                 110         


Val Leu Asn Ser Leu Arg Asn Glu Tyr Thr His Phe Ser Pro Asp Pro 
        115                 120                 125             


Arg Asn Thr Thr Asn Asp Ala Val Ile Ile Pro Tyr Leu Tyr Arg Cys 
    130                 135                 140                 


Met Asp Gly Ala Ala Arg Glu Ile Lys Lys Arg Phe Ser Leu Thr Ile 
145                 150                 155                 160 


Lys Lys Ala Ile Ser Leu Asn Asn Glu Glu Ser Ser Gln Ile His Asp 
                165                 170                 175     


Val Asn Lys Ala Val Glu Tyr Ile Phe Gln Cys Asp Phe Arg Lys Ala 
            180                 185                 190         


Lys Val Asn Asp Leu Asp Lys Asn Gly Lys Val Leu Tyr Gln Lys Asn 
        195                 200                 205             


Gly Lys Ile Lys Thr Lys Met Val Asp Lys Glu Asp Tyr Phe Tyr Ser 
    210                 215                 220                 


Leu Lys Glu Ser Ser Glu Thr Val Gln Asp Asp Ala Ser Lys Lys Gly 
225                 230                 235                 240 


Asn Leu Arg Lys Lys Ile Val Leu Ser Asp Ile Gly Ile Ile Phe Phe 
                245                 250                 255     


Thr Cys Leu Phe Leu Glu Lys Arg Tyr Ile Lys Asn Phe Leu Asp Ala 
            260                 265                 270         


Ile Lys Pro Trp Pro Asn Val Phe Asn Glu Ile Gln Lys Lys Ala Val 
        275                 280                 285             


Phe Glu Val Phe Ser Val Phe His Ile His Leu His Arg Glu Lys Tyr 
    290                 295                 300                 


Asp Ser Cys Arg Pro Glu Tyr Ala Leu Gly Leu Asp Met Leu Asn Glu 
305                 310                 315                 320 


Leu Gln Lys Cys Pro Ala Glu Leu Phe Asp Ile Leu Ser Asp Lys Asp 
                325                 330                 335     


Arg Asp Arg Leu Ser Val Asp Ile His Ala Gln Gly Asp Asn Ile Val 
            340                 345                 350         


Gln Asn Asp Gly Val Thr Val Lys Ser Gly Lys Val Leu Met Lys Arg 
        355                 360                 365             


Met Arg Asp Arg Phe Ala Pro Phe Ala Leu Gln Tyr Ile Asp Arg Gln 
    370                 375                 380                 


Asn Ile Phe Lys Asp Ile Arg Phe Met Val His Leu Gly Asn Tyr Arg 
385                 390                 395                 400 


Phe Lys Phe Tyr Lys Lys Arg Cys Leu Ala Asp Asp Gly Glu Asp Thr 
                405                 410                 415     


Leu Arg Thr Leu Gln Lys Glu Ile Asn Gly Phe Gly Arg Ile Gln Glu 
            420                 425                 430         


Ile Glu Met Glu Arg Lys Lys Asn Tyr Ser Ser Phe Phe Lys Glu Ala 
        435                 440                 445             


Thr Thr Lys Val Asn Glu Tyr Asn Lys Asn Val Gln Glu Leu Lys Ala 
    450                 455                 460                 


Asp Thr Thr Asp Ser Ala Pro Tyr Met Thr Asn Ser Thr Ala His Tyr 
465                 470                 475                 480 


Leu Phe Asp Gly Asn Arg Val Gly Leu Arg Leu Phe Asn Ser Glu Ser 
                485                 490                 495     


Asp Met Lys Ser Phe Val Pro Asn Val Lys Ile Gln Gly Arg Pro Ala 
            500                 505                 510         


Thr Lys Ala Ser Glu Ile Lys Leu Leu Ser Pro Asp Ala Trp Ile Ser 
        515                 520                 525             


Thr Tyr Glu Leu Pro Gly Met Ile Phe Tyr Leu Arg Leu Tyr Lys Glu 
    530                 535                 540                 


Tyr Met Gly Lys Thr Asn Gly Tyr Pro Ser Ala Glu Asp Ile Leu Lys 
545                 550                 555                 560 


Ser Tyr Ile Asp Ala Tyr His Arg Ile Phe Asp Asp Ile Lys Asn Gly 
                565                 570                 575     


Thr Phe Lys Gly Trp Asp Asp Ile Leu Tyr Gln Pro Leu Thr Lys Lys 
            580                 585                 590         


Asp Leu Pro Ile Lys Ile Lys Arg Tyr Ile Asp Gln Pro Asn Ser Thr 
        595                 600                 605             


Gln Ser Ala Tyr Phe His Lys Lys Ser Arg Thr Arg Ile Lys Ile Met 
    610                 615                 620                 


Tyr Tyr Trp Thr Leu Arg Glu Leu Lys Cys Phe Asp Thr Lys Leu Glu 
625                 630                 635                 640 


Lys Met Lys Ser Lys Asp Asn Lys Phe Lys Lys Lys Asp Tyr Val Asp 
                645                 650                 655     


Leu Arg Pro Gly Asp Ile Ala Lys Trp Leu Thr Arg Asp Ile Leu Tyr 
            660                 665                 670         


Phe Met Glu Asp Phe Asp Glu Lys Gly Thr Ile Thr Ser Ala Asn Phe 
        675                 680                 685             


Asn Ser Leu Arg Ser Ala Leu Thr Leu Ser Asp Thr Ser Lys Glu Lys 
    690                 695                 700                 


Val Tyr Gly Met Ile Ser Ser Phe Lys His Pro Phe Leu Ala Lys Ala 
705                 710                 715                 720 


Leu Glu Thr Tyr Asp Lys Glu His Asn Glu Glu Cys Phe Arg Ile Phe 
                725                 730                 735     


Asp Phe Tyr Arg Ala Tyr Leu Thr Lys Arg Ala Asp Tyr Leu Lys Gln 
            740                 745                 750         


Ile Gln Lys Ile Lys Gly Asn Glu Leu Leu Lys Leu Ala Phe Leu His 
        755                 760                 765             


Ser Thr Arg Lys Arg Trp Lys Asp Arg Gly Ile Thr Ala Ile Lys Asp 
    770                 775                 780                 


Leu Ala Met Thr Tyr Glu Gln Phe Glu Leu Pro Arg Gly Ile Phe Thr 
785                 790                 795                 800 


Pro Leu Ala Lys Lys Ile Leu Val Glu Lys Cys Gly Leu Ser Leu Asp 
                805                 810                 815     


Thr Glu Thr Glu Lys Lys Lys Leu Gly Met Ala Asn Leu Ile Asn Phe 
            820                 825                 830         


Tyr Phe Glu Ser Val Leu Lys Asp Lys Asn Gln Asp Phe Tyr Arg Trp 
        835                 840                 845             


Ser Arg His Tyr Lys Ile Phe Asp Leu Leu Glu Thr Asn Thr Ser Lys 
    850                 855                 860                 


Asn Ser Gln Ala His Asn Phe Leu Leu Pro Glu Gln Leu Thr Thr Lys 
865                 870                 875                 880 


Met Arg Lys Asn Lys Glu Phe Glu Ile Asn Asn Leu Ile Arg Asn Lys 
                885                 890                 895     


Ala Lys Lys Ala Ile Glu Ala Glu Ile Lys Tyr Lys Lys Asn Asn Pro 
            900                 905                 910         


Thr Tyr Ile Asp Tyr Phe Asn Glu Asn Phe Lys Ser Thr Thr Glu Val 
        915                 920                 925             


Ala Lys Asn Ile Leu His Asn Ala Tyr Lys Asn Tyr Asp Asp Asn Glu 
    930                 935                 940                 


Arg Ile Leu Arg Arg Tyr Ala Ile Gln Asp Arg Leu Met Phe Leu Met 
945                 950                 955                 960 


Ala Lys Asp Leu Leu Leu Gly Ile Glu Gly Ile Gly Lys Gly Ala Leu 
                965                 970                 975     


Arg Ser Phe Arg Leu Gly Asp Ile Met Pro Asn Lys Asp Lys Thr Ile 
            980                 985                 990         


Leu Asp Leu Leu Val Pro Phe Thr  Val Thr Leu Asn Ile  Asp Gly Ile 
        995                 1000                 1005             


Ser Val  Ser Ile Arg Gln Lys  Asp Ala Ile Lys Ile  Lys Arg Tyr 
    1010                 1015                 1020             


Gly Glu  Phe Tyr Arg Tyr Asn  Ser Asp Thr Arg Leu  Lys Ser Leu 
    1025                 1030                 1035             


Leu Pro  Tyr Leu Ile His Lys  Val Gly Asn Lys Ala  Glu Ile Asn 
    1040                 1045                 1050             


Ile Asp  Ile Asp Arg Glu Glu  Leu Glu Ala Glu Leu  Asn Gln Tyr 
    1055                 1060                 1065             


Asp His  Glu Arg Ile Glu Ile  Met Arg Lys Val Gln  Ser Leu Glu 
    1070                 1075                 1080             


Arg Ser  Ile Ile Ala Lys Val  Gly Gly Glu Lys Asn  Val Glu Lys 
    1085                 1090                 1095             


Glu Ile  Arg Glu Asn Phe Asn  Asn Leu Ile Thr Gln  Lys Gly Asn 
    1100                 1105                 1110             


Ile Pro  Tyr Glu Arg Gln Gly  Lys Ile Leu Val Asn  Ile Arg Asn 
    1115                 1120                 1125             


Ser Phe  Cys His Asn Glu Tyr  Ala Lys Asp Ile Asp  Phe Pro Glu 
    1130                 1135                 1140             


Asn Ile  Pro Leu Pro Gln Ile  Ala Asp Thr Ile Val  Ser Leu Phe 
    1145                 1150                 1155             


Glu Ala  Glu Arg Lys Asn Arg  Pro Lys Gly Glu Thr  Met 
    1160                 1165                 1170     


<210>  1649
<211>  1090
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1649

Met Asn Ile Pro Ala Leu Val Glu Asn Gln Lys Lys Tyr Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Val Met Ala Met Leu Asn Ala Gln Thr Val Leu Asp His Ile 
            20                  25                  30          


Gln Lys Val Ala Asp Ile Glu Gly Glu Gln Asn Glu Asn Asn Glu Asn 
        35                  40                  45              


Leu Trp Phe His Pro Val Met Ser His Leu Tyr Asn Ala Lys Asn Gly 
    50                  55                  60                  


Tyr Asp Lys Gln Pro Glu Lys Thr Met Phe Ile Ile Glu Arg Leu Gln 
65                  70                  75                  80  


Ser Tyr Phe Pro Phe Leu Lys Ile Met Ala Glu Ser Gln Arg Glu Tyr 
                85                  90                  95      


Ser Asn Lys Lys Asn Lys Gln Asn Arg Val Glu Val Asn Ser Asn Asp 
            100                 105                 110         


Ile Phe Glu Val Leu Lys Arg Ala Phe Gly Val Leu Lys Met Tyr Arg 
        115                 120                 125             


Asp Gln Thr Asn His Tyr Lys Thr Tyr Asp Glu Lys Leu Ile Asp Gly 
    130                 135                 140                 


Cys Glu Phe Leu Thr Lys Thr Glu Gln Pro Leu Ser Gly Met Ile Asn 
145                 150                 155                 160 


Ser Tyr Tyr Thr Val Ala Leu Arg Asn Ile Lys Glu Arg Tyr Gly Tyr 
                165                 170                 175     


Lys Thr Glu Asp Leu Thr Phe Ile Gln Asp Asn Arg Tyr Lys Phe Val 
            180                 185                 190         


Lys Asp Ala Tyr Gly Lys Arg Lys Ser Gln Val Asn Thr Gly Phe Phe 
        195                 200                 205             


Leu Ser Leu Gln Asp Tyr Asn Gly Asp Thr Thr Lys Lys Leu His Leu 
    210                 215                 220                 


Ser Gly Val Gly Ile Ala Leu Leu Ile Cys Leu Phe Leu Asp Lys Gln 
225                 230                 235                 240 


Tyr Ile Asn Leu Phe Leu Ser Arg Leu Pro Ile Phe Ser Ser Tyr Asn 
                245                 250                 255     


Ala Gln Ser Glu Glu Arg Arg Ile Ile Ile Arg Ser Phe Gly Ile Asn 
            260                 265                 270         


Ser Ile Lys Leu Pro Lys Asp Arg Ile His Ser Glu Lys Ser Asn Lys 
        275                 280                 285             


Ser Val Ala Met Asp Met Leu Asn Glu Val Lys Arg Cys Pro Asp Glu 
    290                 295                 300                 


Leu Phe Thr Thr Leu Ser Thr Glu Lys Gln Ser Arg Phe Arg Ile Ile 
305                 310                 315                 320 


Ser Asn Asp His Asn Glu Val Leu Met Lys Arg Ser Ser Asp Arg Phe 
                325                 330                 335     


Val Gln Leu Leu Leu Gln Tyr Ile Asp Tyr Gly Lys Gln Phe Lys Asn 
            340                 345                 350         


Ile Arg Phe His Val Asn Met Gly Lys Leu Arg Tyr Leu Leu Lys Ala 
        355                 360                 365             


Asp Lys Glu Cys Ile Asp Gly Gln Thr Arg Val Arg Val Ile Lys Gln 
    370                 375                 380                 


Pro Leu Asn Gly Phe Gly Arg Gln Asp Glu Val Glu Ala Leu Arg Lys 
385                 390                 395                 400 


Gln Glu Asn Gly Thr Phe Gly Lys Ser Gly Ile Arg Ile Arg Asp Phe 
                405                 410                 415     


Glu Asn Met Lys Arg Asp Asp Asp Asn Pro Ala Asp Tyr Pro Tyr Ile 
            420                 425                 430         


Val Asp Thr Tyr Thr His Tyr Met Leu Glu Asn Asn Lys Val Glu Met 
        435                 440                 445             


Tyr Ile Ser Lys Asp Asp Asn Pro Ala Pro Leu Leu Pro Glu Ile Glu 
    450                 455                 460                 


Glu Asp Arg Tyr Ala Val Lys Thr Ile Pro Ser Cys Arg Met Ser Thr 
465                 470                 475                 480 


Leu Glu Phe Pro Ala Met Ala Phe His Met Phe Leu Leu Gly Ser Glu 
                485                 490                 495     


Arg Thr Glu Arg Arg Ile Lys Asp Val Tyr Asp Arg Tyr Lys Lys Leu 
            500                 505                 510         


Phe Glu Ala Met His Lys Glu Glu Val Thr Ala Glu Asn Ile Ser Ser 
        515                 520                 525             


Phe Gly Ile Ala Glu Arg Asp Leu Pro Lys Lys Ile Leu Asp Ile Ile 
    530                 535                 540                 


Asn Gly Asn Ala Gln Gly Arg Asp Val Asp Ala Tyr Ile Lys Thr Thr 
545                 550                 555                 560 


Ile Asp Asp Met Ile Ala Asp Thr Glu His His Ile Lys Gln Leu Lys 
                565                 570                 575     


Asp Asp Arg Lys Ala Val Arg Ser Ala Asp Asn Lys Met Gly Lys Arg 
            580                 585                 590         


Asn Phe Lys Lys Ile Ser Thr Gly Lys Leu Ala Gly Phe Leu Ala Lys 
        595                 600                 605             


Asp Ile Val Met Phe Gln Pro Ser Thr Asn Asp Gly Glu Asn Lys Ile 
    610                 615                 620                 


Thr Gly Leu Asn Tyr Arg Ile Met Gln Ser Ala Ile Ala Val Tyr Asp 
625                 630                 635                 640 


Ser Gly Asp Asp Tyr Glu Ala Lys Lys Gln Phe Lys Gln Met Phe Glu 
                645                 650                 655     


Lys Ala Arg Leu Ile Gly Lys Gly Ile Thr Glu Ala His Pro Phe Leu 
            660                 665                 670         


Tyr Lys Val Phe Ala Arg Ser Val Pro Ala Asn Ala Val Asp Phe Tyr 
        675                 680                 685             


Glu Arg Tyr Leu Ile Glu Arg Lys Asp Tyr Leu Thr Gly Leu Phe Asn 
    690                 695                 700                 


Glu Ile Lys Lys Gly Asn Lys Val Asp Ile Pro Phe Ile Arg Arg Asp 
705                 710                 715                 720 


Gln Asn Lys Trp Lys Thr Pro Val Met Lys Thr Leu Gly Arg Ile Tyr 
                725                 730                 735     


Asn Glu Asp Leu Pro Val Glu Leu Pro Arg Gln Met Phe Asp Asp Glu 
            740                 745                 750         


Ile Lys Ser His Leu Lys Ser Leu Ser Gln Met Ser Gly Ile Asp Phe 
        755                 760                 765             


Asp Asn Ala Asn Val Thr Tyr Leu Ile Ala Glu Tyr Met Lys Arg Val 
    770                 775                 780                 


Leu Gly Asp Asp Phe Gln Asn Phe Tyr Gln Trp Asn Arg Asn Tyr Arg 
785                 790                 795                 800 


Tyr Met Asn Ile Leu Lys Gly Glu Tyr Asp Ser Lys Gly Thr Leu Leu 
                805                 810                 815     


Cys Asn Phe Thr Ser Val Glu Glu Arg Glu Ala Leu Trp Lys Glu Arg 
            820                 825                 830         


Glu Asp Arg Ser Gly Ser Tyr Arg Lys Leu Ala Ala Lys Lys Ile Lys 
        835                 840                 845             


Ser Asn Arg Leu Thr Arg Asn Ala Ser Thr Asp Glu Val Asn Ser Ile 
    850                 855                 860                 


Leu Asp Lys Arg Leu Ser Asn Ser Arg Asn Glu Tyr Gln Lys Asn Gly 
865                 870                 875                 880 


Lys Ile Ile Arg Arg Tyr Lys Val Gln Asp Ala Leu Leu Phe Leu Leu 
                885                 890                 895     


Ala Lys Lys Ser Leu Thr Glu Met Ala Asp Phe Asp Gly Asn Lys Phe 
            900                 905                 910         


Lys Leu Lys Glu Ile Met Pro Asp Thr Glu Lys Gly Ile Leu Ser Glu 
        915                 920                 925             


Ile Met Pro Met Thr Phe Thr Phe Glu Lys Gly Gly Glu Arg Tyr Thr 
    930                 935                 940                 


Ile Thr Ser Lys Gly Met Lys Leu Lys Asn Tyr Gly Asp Phe Phe Val 
945                 950                 955                 960 


Leu Ala Asn Asp Lys Arg Leu Cys Arg Leu Leu Lys Ile Val Gly Ser 
                965                 970                 975     


Asn Thr Val Ser Lys Glu Asp Ile Met Glu Glu Phe Lys Lys Tyr Asp 
            980                 985                 990         


Gln Cys Arg Pro Glu Ile Ala Ser  Ile Val Phe Asn Leu  Glu Lys Trp 
        995                 1000                 1005             


Ala Phe  Asp Thr Tyr Pro Glu  Leu Ser Ala Lys Val  Asp Arg Glu 
    1010                 1015                 1020             


Glu Gln  Val Asp Phe Lys Phe  Ile Leu Asn Val Leu  Leu Asn Lys 
    1025                 1030                 1035             


Lys Asn  Ile Asn Asn Glu Gln  Ser Tyr Ile Leu Arg  Lys Ile Arg 
    1040                 1045                 1050             


Asn Ala  Phe Asp His Asn Asn  Tyr Pro Asp Lys Gly  Leu Val Glu 
    1055                 1060                 1065             


Ile Lys  Ala Leu Pro Glu Ile  Ala Met Ser Ile Lys  Lys Thr Phe 
    1070                 1075                 1080             


Gly Glu  Tyr Ala Met Met Lys  
    1085                 1090 


<210>  1650
<211>  1123
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1650

Met Lys Ile Pro Gln Ile Ile Glu Asp Asn Lys His Leu Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Thr Met Ala Leu Ala Asn Ile Arg Asn Ile Leu Asp His Ile 
            20                  25                  30          


Ala Thr Leu Ala Cys Ile Glu Asn Asp Phe Asn Ala Asp Ser Asp Asp 
        35                  40                  45              


Phe Trp His His Pro Cys Ile Glu Ile Ile Asn Pro Gln Asn Leu Cys 
    50                  55                  60                  


Asn Asp Val Thr Lys Ala Asp Phe Val Thr Glu Lys Leu Lys Ser His 
65                  70                  75                  80  


Phe Pro Phe Val Val Ile Met Ala Glu Ala Lys Arg Gln Lys Asp Ile 
                85                  90                  95      


Ala Trp Ala Lys Asn Gln Ala Lys Lys Ala Phe Glu Asn Arg Asp Phe 
            100                 105                 110         


Gln Lys Gln Gln Glu Phe Asn Lys Lys Gln Lys Ser Leu Leu Ser Ile 
        115                 120                 125             


Thr Asn Ala Asp Ile Tyr Arg Met Leu Asn Asn Leu Phe Arg Val Leu 
    130                 135                 140                 


Thr Ser Tyr Arg His Tyr Thr Ser His Tyr Leu Ile Asn Tyr Ile Tyr 
145                 150                 155                 160 


Phe Asn Glu Gly Ser Asn Leu Leu Lys Tyr Asn Glu Gln Pro Leu Ser 
                165                 170                 175     


Tyr Asn Leu Asn Asp Tyr Phe Thr Ile Ala Leu Arg Asp Thr Ala Gln 
            180                 185                 190         


Lys Tyr Ser Tyr Ser Pro Glu Ala Leu Ser Phe Ile Gln Ser Ser Arg 
        195                 200                 205             


Tyr Lys Ile Glu Asn Arg Arg Lys Ile Leu Asp Thr Asp Phe Phe Leu 
    210                 215                 220                 


Ser Ile Gln His Arg Asn Gly Asp Ser Asn Pro Lys Asn Leu His Ile 
225                 230                 235                 240 


Ser Gly Val Gly Val Ala Leu Leu Ile Cys Leu Phe Leu Glu Lys Lys 
                245                 250                 255     


Tyr Val Asn Val Phe Leu Gln Lys Leu Pro Ile Tyr Gly Thr Tyr Lys 
            260                 265                 270         


Lys Gln Ser Met Glu Ala Asn Ile Ile Arg Gln Thr Phe Gly Ile His 
        275                 280                 285             


Thr Ala Lys Leu Pro Lys Glu Arg Ile Val Ser Glu Lys Ser Asp Phe 
    290                 295                 300                 


Ser Ile Gly Met Asp Met Leu Asn Glu Leu Lys Arg Cys Pro Lys Ala 
305                 310                 315                 320 


Leu Phe Ser Thr Leu Ser Tyr Ala Asp Gln Asn Ala Phe Arg Ile Val 
                325                 330                 335     


Ser Ser Asp Met Asn Asp Val Leu Gln Val Arg His Thr Asp Arg Phe 
            340                 345                 350         


Ala Gln Leu Ser Leu Glu Tyr Ile Asp Arg Arg Glu Leu Phe Ser Asp 
        355                 360                 365             


Ile Arg Phe His Leu Asn Met Gly Lys Leu Arg Tyr Leu Lys Thr Ala 
    370                 375                 380                 


Asp Lys His Cys Ile Asp Gly Ile Ser Arg Val Arg Val Leu Glu Asp 
385                 390                 395                 400 


Lys Ile Asn Ala Phe Gly Arg Ile His Glu Phe Glu Ala Arg Arg Lys 
                405                 410                 415     


Glu Leu Gly Phe Val Glu Cys Tyr Glu Gln Gly Gly Arg Ala Ile Ser 
            420                 425                 430         


Thr Asn Thr Asn Ile Glu Ile Arg Asp Phe Glu His Val Lys Arg Asp 
        435                 440                 445             


Asp Ser Asn Pro Asp Ser Tyr Pro Tyr Ile Ile Asp Thr Tyr Thr His 
    450                 455                 460                 


Tyr Ile Leu Glu Asn Asn Lys Ile Gly Met His Ile Gly Asp Tyr Trp 
465                 470                 475                 480 


Pro Asp Leu Ile Lys Leu Asp Glu His Lys Trp Thr Val Tyr Asn Glu 
                485                 490                 495     


Asn Pro Thr Cys Phe Met Ser Ser Leu Glu Leu Pro Ala Met Met Phe 
            500                 505                 510         


His Met Met Leu Cys Gly Ser Asp Ala Thr Glu Ser Leu Ile Lys Ala 
        515                 520                 525             


Glu Val Asp Lys Tyr Lys Lys Leu Phe Gly Ala Met Ala Asn Gly Thr 
    530                 535                 540                 


Leu Thr Lys Glu Asn Ile Ser Gly Phe Gly Ile Ala Glu Glu Asn Ile 
545                 550                 555                 560 


Pro Gln Lys Val Ile Asp Cys Val Asn Gly Lys Thr Ser Gly Lys Gly 
                565                 570                 575     


Leu Asp Lys Gln Ile Lys Lys Glu Ile Asp Glu Met Leu Ala Asp Thr 
            580                 585                 590         


Asn Leu Arg Ile Glu Arg Leu Lys Ser Asp Lys Arg Ser Val Ala Ser 
        595                 600                 605             


Thr Gln Asn Lys Met Gly Lys Arg Gly Phe Arg Ser Ile Gln Pro Gly 
    610                 615                 620                 


Lys Leu Ala Asp Trp Leu Ala Ala Asp Ile Val Lys His Gln Pro Ser 
625                 630                 635                 640 


Leu Leu Lys Gly Val Asp Tyr Gly Thr Asp Arg Ile Thr Gly Met Asn 
                645                 650                 655     


Tyr Arg Val Met Gln Ser Thr Ile Ala Thr Phe Asn Ala Thr Thr Pro 
            660                 665                 670         


Glu His Ser Leu Glu Glu Leu Lys Lys Val Phe Ser Ala Ala Gln Leu 
        675                 680                 685             


Ile Gln Cys Glu Lys Lys Glu His Pro Phe Leu Tyr Lys Ala Leu Asp 
    690                 695                 700                 


Arg Asn Pro Gln Asn Thr Ile Asp Leu Tyr Glu Phe Tyr Leu Ser Ala 
705                 710                 715                 720 


Lys Gln Ser Tyr Tyr Lys Ser Met Arg Arg Asn Ile Glu Asn Gly Glu 
                725                 730                 735     


Asn Val Lys Leu Pro Tyr Leu Asn Thr Asp Arg Asn Lys Trp Met Arg 
            740                 745                 750         


Arg Gly Ser Val Tyr Tyr Ser Thr Met Gly Glu Ile Tyr Leu Lys Asp 
        755                 760                 765             


Met Pro Ile Glu Leu Pro Arg Gln Met Phe Asp Lys Lys Ile Lys Glu 
    770                 775                 780                 


Ala Leu Ala Lys Leu Pro Ser Met Lys Asp Val Asp Met Gln His Cys 
785                 790                 795                 800 


Asn Val Thr Phe Leu Ile Ala Glu Tyr Leu Lys Lys Glu Leu Lys Asp 
                805                 810                 815     


Asp Ser Gln Pro Phe Tyr Gln Trp Asn Arg Asn Tyr Arg Phe Thr Asp 
            820                 825                 830         


Met Met Ile Cys Glu Glu Asn Arg Ser Thr Arg Ala Leu Ser Thr His 
        835                 840                 845             


Phe Ile Pro Val Ala Leu Arg Glu Glu Ile Trp Glu Lys Arg Ser Glu 
    850                 855                 860                 


Leu Arg Ala Ala Tyr Lys Glu Trp Ala Leu Pro Arg Leu Ser Lys Asn 
865                 870                 875                 880 


Arg Asp Thr Glu Arg Leu Ser Pro Ala Gln Lys Ser Glu Leu Leu Asp 
                885                 890                 895     


Ala Arg Ile Ala Lys Cys Arg Asn Glu Tyr Gln Lys Asn Glu Lys Ile 
            900                 905                 910         


Ile Arg Arg Tyr Lys Val Gln Asp Ala Leu Met Phe Met Met Val Lys 
        915                 920                 925             


Asp Met Phe Gly Lys Gly Val Phe Thr Ala Glu Ser Lys Glu Phe Ala 
    930                 935                 940                 


Leu Ser Ala Ile Thr Pro Asp Ala Lys Arg Gly Ile Leu Ser Glu Val 
945                 950                 955                 960 


Ile Pro Ile Asp Phe Lys Phe Ser Ile Asp Gly Lys Thr Tyr Thr Ile 
                965                 970                 975     


His Ser Asn Gly Met Lys Ile Lys Asn Tyr Gly Asp Phe Tyr Lys Leu 
            980                 985                 990         


Ile Asn Asp Lys Arg Met Lys Ser  Ile Leu Lys Ile Ile  Thr His Asn 
        995                 1000                 1005             


Val Ile  Asp Lys Asp Leu Leu  Glu Lys Glu Phe Ser  Ser Tyr Asp 
    1010                 1015                 1020             


Asp Lys  Arg Pro Glu Ala Ile  Glu Ile Val Phe Glu  Phe Glu Lys 
    1025                 1030                 1035             


Ala Ala  Tyr Ser Lys Tyr Pro  Glu Leu Glu Glu Leu  Val Leu Ser 
    1040                 1045                 1050             


Glu Asn  His Phe Asp Phe Gly  Thr Leu Leu Arg Glu  Leu Gln Ala 
    1055                 1060                 1065             


Lys Lys  Val Leu Ser Gln Asn  Asp Gly His Tyr Leu  Ser Gln Ile 
    1070                 1075                 1080             


Arg Asn  Ala Phe Ser His Asn  Ser Tyr Pro Arg Asn  Leu Arg Ile 
    1085                 1090                 1095             


Thr Ser  Asn Ile Pro Glu Ile  Ala Gln Glu Met Ile  Asn Ile Phe 
    1100                 1105                 1110             


Arg Ile  Thr Thr Pro Leu Lys  Thr Lys Lys 
    1115                 1120             


<210>  1651
<211>  1109
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1651

Met Glu Ser Glu Lys Gln Phe Arg Thr Ile Phe Asn Asn Lys Gly Asn 
1               5                   10                  15      


Ile Gly Pro Ile Ala Glu Lys Ala Lys Arg Asn Phe Asp Leu Ile Leu 
            20                  25                  30          


Lys Asn Glu His Ser Lys Thr Glu Arg Ile Tyr His Phe Cys Ile Gly 
        35                  40                  45              


His Val Phe Lys Asn Ile Asp Lys Ser Ile Phe Glu Ser Lys Leu Asn 
    50                  55                  60                  


Glu Asn Leu Lys Lys Phe Gln Pro Thr Lys Tyr Ile Thr Leu Gln Lys 
65                  70                  75                  80  


Asp Phe Phe Thr Phe Glu Thr Glu Leu Tyr Glu Leu Ile Lys Arg Ile 
                85                  90                  95      


Arg Asp Cys Asn Ser His Tyr Val His Thr Phe Asp Lys Leu Ser Glu 
            100                 105                 110         


Glu Asn Ile Glu Lys Ser Asp Lys Ile Ile Pro Phe Ile Lys Asp Ala 
        115                 120                 125             


Phe Gln Phe Ser Ile Ile Ser Asn Tyr Ile Lys Glu Asn Asn Leu Ser 
    130                 135                 140                 


Phe Glu Lys Phe Asn Glu Asn Glu Asn Ser His Lys Glu Ile Val Lys 
145                 150                 155                 160 


Ser Ile Ile Asn Lys Phe Phe Pro Asn Gly Glu Met Gln Lys Asn Val 
                165                 170                 175     


Arg Asp Lys Phe Ser Lys Leu Asn Leu Lys Lys Val Ile Asp Glu Leu 
            180                 185                 190         


Leu Phe Ile Thr Val Asp Glu Asp Phe Glu Tyr Asn Leu Ile Glu Asn 
        195                 200                 205             


His Pro Ile Phe Thr Ile Lys Lys Gly Lys Tyr Leu Ser Asn Ile Ala 
    210                 215                 220                 


His Leu Phe Ile Leu Ser Leu Phe Leu Tyr Lys Asn Glu Ala Asn Glu 
225                 230                 235                 240 


Leu Ile Ser Lys Ile Arg Gly Phe Lys Arg Asn Asp Asp Glu Phe His 
                245                 250                 255     


His Lys Arg Asp Ile Phe Thr Phe Phe Ser Lys Lys Leu Thr Ser Gln 
            260                 265                 270         


Asp Ile Asn Asn Glu Glu Lys Asn Leu Ile Asn Phe Arg Asp Ile Ile 
        275                 280                 285             


Gln Tyr Leu Asn Lys Tyr Pro Thr Ala Trp Asn Lys Asn Ile Glu Pro 
    290                 295                 300                 


Glu Arg Gln Phe Thr Thr Met Thr Asn Ser Leu Glu Lys Tyr Val Ile 
305                 310                 315                 320 


Glu Thr Glu Ile Phe Arg Ser Phe Pro Thr Phe Lys Gly Lys Glu Glu 
                325                 330                 335     


His Asn Tyr Phe Leu Lys Tyr Val Ile Thr Asn Leu Phe Lys Lys Lys 
            340                 345                 350         


Lys His Leu Phe Asp Leu Asp Glu Tyr Lys Ile Ser Lys Glu Leu Glu 
        355                 360                 365             


Val Lys Leu His Gln Glu Tyr Tyr Leu Ser Pro Glu Leu Lys Asp Ala 
    370                 375                 380                 


Asn Phe Arg Leu Asp Gln Leu Lys Asn Lys Lys Asn Thr Asn Ser Phe 
385                 390                 395                 400 


Glu Glu Glu Lys Ile Glu Glu Glu Ile Glu Glu Leu Ser Glu Lys Glu 
                405                 410                 415     


Asn Ser Ile Leu Glu Lys Leu Lys Lys Arg Ile Lys Glu Asn Lys Leu 
            420                 425                 430         


Leu Met Ser Tyr Gly Arg Asn Gln Asp Arg Phe Met Glu Ile Ala Leu 
        435                 440                 445             


Arg Phe Leu Ala Glu Asn Asn Tyr Phe Gly Lys Asn Ala Lys Phe Lys 
    450                 455                 460                 


Leu Tyr Gln Phe Tyr Thr Thr Asp Glu Gln Ile Asp Tyr Leu Ala Lys 
465                 470                 475                 480 


Ala Lys Lys Glu Lys Thr Lys Lys Glu Tyr Asp Lys Ile Lys Tyr His 
                485                 490                 495     


Gln Gly Lys Val Val Asp Tyr Val Thr Tyr Lys Glu His Leu Lys Lys 
            500                 505                 510         


Tyr Pro Asp Trp Asp Phe Pro Phe Ala Ile Gln Asn Asn Ser Ile Gln 
        515                 520                 525             


Ile Lys Ile Gln Leu Pro Asn Asn Glu Trp Lys Leu Phe Ser Ile Gln 
    530                 535                 540                 


Arg Lys Leu Phe Ile Tyr Leu Leu Glu Asp Ala Leu Tyr Gly Asn Asp 
545                 550                 555                 560 


Lys Lys Ile Asp Asn Arg Gly Asn Ile Leu Leu Ser Asn Tyr Phe Leu 
                565                 570                 575     


Ser Asn Leu Ile Pro Glu Phe Asn Gln Leu Lys Asn Ser Leu Ala Asp 
            580                 585                 590         


Asn Ser Ile Thr Thr Glu His Arg Lys Leu Phe Pro Lys Arg Leu Leu 
        595                 600                 605             


Ala Lys Tyr Gln Glu Pro Ile Arg Asn Thr Thr Glu Gln Tyr Asn Pro 
    610                 615                 620                 


Phe Leu Glu Ile Leu Val Glu Thr Lys Lys Gln Glu Asn Arg Tyr Asp 
625                 630                 635                 640 


Asn Leu Leu Lys Lys Ser Lys Glu Leu Asp Leu Glu Asp Lys Phe Gln 
                645                 650                 655     


Lys Lys Asn Lys Gly Lys Gln Phe Lys Leu Arg Phe Leu Arg Lys Ala 
            660                 665                 670         


Trp Asn Leu Met Tyr Phe Arg Lys Ile Tyr Asp Lys Gln Val Glu Glu 
        675                 680                 685             


Asn Gly His His Lys Arg Phe Asn Ile Thr Lys Glu Glu Phe Asn Asp 
    690                 695                 700                 


Phe Cys Arg Trp Ile Phe Ala Phe Asp Glu Val Thr Glu Tyr Lys Lys 
705                 710                 715                 720 


Tyr Leu Glu Gln Leu Phe Thr Glu Lys Arg Phe Phe Asp Asp Glu Asp 
                725                 730                 735     


Phe Lys Thr Leu Phe Phe Ser Ser Asp Ser Leu Asn Glu Met Tyr Asn 
            740                 745                 750         


Lys Thr Lys Glu Asn Phe Glu His Trp Ile Asn Gly Arg Tyr Lys Lys 
        755                 760                 765             


Lys Glu Arg Lys Gly Asp Tyr Glu Lys Leu Leu Ala Lys Asp Ile Ile 
    770                 775                 780                 


Tyr Ile Asn Ile Ser His Phe Ile Asn Tyr Leu Lys Gln Lys Lys Lys 
785                 790                 795                 800 


Ile Thr Thr Glu Asn Glu Leu Ile Lys Tyr Asn Ala Ser Glu Asn Ile 
                805                 810                 815     


Pro Phe Leu Ile Asp Ser Phe Tyr Tyr Lys Glu Ile Leu Pro Lys Glu 
            820                 825                 830         


Glu Tyr Lys Glu Asn Gly Lys Leu Phe Asn Glu Leu Arg Thr Thr Lys 
        835                 840                 845             


Leu Glu Asp Ala Leu Leu Tyr Glu Ile Ala Met Gln Tyr Leu Lys Leu 
    850                 855                 860                 


Asp Lys Thr Ile Ile Asn Lys Ala Lys Glu Asn Val Thr Glu Ile Leu 
865                 870                 875                 880 


Thr Ser Thr Ile Glu Phe Asp Ile Lys Asp Ala Asn Lys Lys His Leu 
                885                 890                 895     


Tyr Asn Leu Val Val Pro Phe Ser Lys Ile Glu Asn Leu Ala Val Leu 
            900                 905                 910         


Phe Lys Leu Met Pro Asn Asn Lys Asp Thr Phe Leu Thr Lys Ile Tyr 
        915                 920                 925             


Thr Ser Thr Lys Leu Leu Phe Pro Glu Leu Glu Tyr Glu Lys Glu Glu 
    930                 935                 940                 


Ser Asp Asn Lys Lys Ile Arg Glu Asn Leu Leu Glu Lys Lys Glu Leu 
945                 950                 955                 960 


Ser Phe Glu Ser Leu Asn Ala Ile Asn Asn Ile Ile Ile Ser Ser Ser 
                965                 970                 975     


Val Lys Val Ser Lys Val Phe Met Ala Leu Glu Lys Tyr Phe Ile Ile 
            980                 985                 990         


Lys Ile Asp Thr Arg Ile Pro Tyr  Gly Lys Asp Tyr Val  Asn Val Tyr 
        995                 1000                 1005             


Asp Ile  His Leu Asp Asp Asn  Asn Thr Phe Glu Asn  Glu Tyr Asn 
    1010                 1015                 1020             


Glu Asn  Asp Thr Arg Asn Asn  Val Ala His Phe Asp  Ile Pro Lys 
    1025                 1030                 1035             


Ile Asn  Tyr Asp Ile Phe Ile  Lys Asn Ile Glu Ala  Lys Phe Ile 
    1040                 1045                 1050             


Thr Asn  Glu Ile Lys Pro Leu  Lys Glu Lys Ser Phe  Glu Asp Leu 
    1055                 1060                 1065             


Asn Gln  Asn Ile Lys Asp Val  Cys Ser Ile Phe Phe  Lys Ile Leu 
    1070                 1075                 1080             


His Ser  Asn Leu Tyr Pro Arg  Gly Lys Gly Asn Lys  Lys Thr Glu 
    1085                 1090                 1095             


Met Glu  Gln Lys Tyr Phe Asn  Gln Phe Leu Glu 
    1100                 1105                 


<210>  1652
<211>  1063
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1652

Met Phe Asp Asn Glu Gln Lys Asn Leu Glu Lys Glu Pro Tyr Trp Gly 
1               5                   10                  15      


Val Phe Leu Asn Gln Ala Arg Leu Asn Ala Tyr Ile Ala Leu Arg Asp 
            20                  25                  30          


Ile Ser Glu Arg Leu Glu Glu Asn Ala Ala Asp Glu Asp Ser Leu Ser 
        35                  40                  45              


Glu Trp Pro Val Leu Lys Tyr Leu Asp Asn Asp Thr Asp Ala Val Lys 
    50                  55                  60                  


Ser Arg Arg Ile Phe Asp Leu Val Glu Lys His Phe Ser Met Leu Lys 
65                  70                  75                  80  


Ile Ile Tyr Gly Gly Glu Lys Glu Gly Asp Leu Val Lys Arg Ser Lys 
                85                  90                  95      


Glu Tyr Lys Ile Ile Leu Lys Cys Leu Phe Arg Ala Leu Asn Phe Tyr 
            100                 105                 110         


Arg Asn Lys Phe Cys His Met Tyr Ser Gly Asn Arg Ala Arg Lys Tyr 
        115                 120                 125             


Asn Glu Lys Glu Leu Ile Lys Tyr Leu Glu Asp Cys Phe Asp Ala Ser 
    130                 135                 140                 


Val Arg Lys Ile Lys Glu Leu Arg Arg Leu Asp Glu Lys Asp Val Leu 
145                 150                 155                 160 


His Leu Arg Arg Lys Ile Ala Glu Gly Lys Asp Ala Asn Lys Arg Val 
                165                 170                 175     


Ile Asp Asn Pro Gln Phe Arg Tyr Pro Phe Lys Asn Glu Lys Gly Glu 
            180                 185                 190         


Leu Asn Glu Lys Gly Leu Tyr Phe Leu Ala Ser Ile Phe Leu Asp Lys 
        195                 200                 205             


Lys Glu Ala His Glu Phe Leu Lys Lys Gln Glu Tyr Phe Lys Asn Asp 
    210                 215                 220                 


Ser Glu Pro Lys Tyr Arg Ala Thr Leu Glu Ser Phe Tyr His Tyr Arg 
225                 230                 235                 240 


Ile Lys Leu Pro Arg Pro Val Ile Glu Ser Asp Val Asp Lys Asn Gly 
                245                 250                 255     


Leu Ala Leu Asp Met Leu Asn Glu Leu Lys Lys Cys Pro Lys Glu Leu 
            260                 265                 270         


Phe Asp Leu Leu Ser Lys Glu Gln Gln Glu Lys Phe Arg Val Val Asp 
        275                 280                 285             


Ser Glu Asp Ala Asp Glu Glu Gly Asn Glu Ile Leu Met Arg Arg Tyr 
    290                 295                 300                 


Ser Asp Arg Phe Pro Tyr Leu Ala Leu Arg Tyr Cys Asp Glu Asn Gln 
305                 310                 315                 320 


Val Phe Glu Arg Ile Arg Phe Gln Ile Asp Leu Gly Arg Tyr Tyr Phe 
                325                 330                 335     


Lys Phe Tyr Pro Lys Glu Thr Ile Asp Gly Lys Thr Gln Gln Arg Ser 
            340                 345                 350         


Leu Asp Lys Arg Leu Lys Ile Phe Gly Arg Ile Lys Asp Val Lys Ser 
        355                 360                 365             


Lys Val Glu Gln Glu Trp Ser Gly Ile Ile Lys Ser Pro Asp Thr Ile 
    370                 375                 380                 


Glu Glu Asn Pro Asn Glu Pro Tyr Lys Leu Lys Thr Thr Pro Arg Tyr 
385                 390                 395                 400 


Asn Ile Val Asp Asn Gln Ile Gly Phe Val Ile Thr Gly Asp Lys Asn 
                405                 410                 415     


Leu Pro Asp Val Lys Arg Pro Asp Gly Arg Ile Glu Leu Glu Lys Pro 
            420                 425                 430         


Asp Gly Trp Leu Ser Ile Tyr Glu Leu Pro Gly Met Leu Phe His Gly 
        435                 440                 445             


Leu Lys Tyr Gly Phe Asp Lys Thr Glu Arg Met Ile Lys Ile Tyr Ile 
    450                 455                 460                 


Glu Lys Gln Arg Lys Ile Cys Lys Glu Ile Cys Glu Lys Gly Thr Ile 
465                 470                 475                 480 


Thr Pro Asp Asp Gly Glu Ser Met Pro Glu Ala Leu Lys Gly Gly Ala 
                485                 490                 495     


Lys Ala Ala Lys Arg Asn Tyr Ser Glu Lys Lys Leu Glu Arg Met Leu 
            500                 505                 510         


Gln Asp Thr Glu Gln Arg Ile Arg Ala Ile Gln Thr Thr Gln Lys Arg 
        515                 520                 525             


Met Asp Glu Pro Gly Asn Lys Pro Gly Lys Lys Lys Phe Phe Asp Ile 
    530                 535                 540                 


Arg Ala Gly Lys Leu Ala Asp Phe Leu Ala Arg Asp Ile Met Ala Leu 
545                 550                 555                 560 


Gln Arg Phe Asp Pro Ala Lys His Gly Lys Asp Lys Leu Thr Ala Ile 
                565                 570                 575     


Asn Phe Gln Val Leu Gln Ala Thr Leu Ala Phe Tyr Gly Ala Lys Lys 
            580                 585                 590         


Asp Val Ile Glu Asp Met Phe Lys Gly Ile Gly Leu Leu Glu Gly Asp 
        595                 600                 605             


Asn Pro His Pro Phe Leu Asn Gln Ile Asp Pro Ala Gln Tyr Asn Ser 
    610                 615                 620                 


Ile Ala Gly Phe Tyr Gln Ala Tyr Leu Gln Lys Lys Arg Ser Tyr Leu 
625                 630                 635                 640 


Glu Asp Tyr Arg Lys Glu Glu Glu Tyr Asp Glu Gln Phe Leu Arg Pro 
                645                 650                 655     


Lys Arg Gln Arg Tyr Ala Gln Glu Lys Arg Glu Ile Lys Thr Val Ala 
            660                 665                 670         


Arg Gln Leu Leu Asp Asn Pro Val Asn Val Pro Lys Asn Phe Phe Lys 
        675                 680                 685             


Lys Glu Ile Glu Glu Phe Val Phe Ser Gln Asp Pro Ser Leu Lys Lys 
    690                 695                 700                 


Ser Lys Met Asn Thr Ala Tyr Met Ile Gln Ala Leu Phe Glu Lys His 
705                 710                 715                 720 


Tyr Gly Arg Gln Gln Pro Phe Tyr Ser Tyr Asn Arg Thr Tyr Pro Val 
                725                 730                 735     


Val Ser Lys Ala Ile Glu Tyr Gly Lys Lys Gly Lys Asn Lys Lys Ile 
            740                 745                 750         


Ala Lys Val Leu Met Ala Ile Glu Pro Lys Leu Asn Tyr Met Glu Ile 
        755                 760                 765             


Lys Lys Ile Val Asn Glu Met Pro Asp Gly Gln Tyr Glu Pro Glu Asn 
    770                 775                 780                 


Leu Lys Arg Asn Leu Tyr Glu Gly Tyr Lys Asp Tyr Glu Lys Asp Glu 
785                 790                 795                 800 


Arg Ile Ile Arg Arg Cys Lys Val Gln Asp Val Val Ser Phe Met Met 
                805                 810                 815     


Val Glu Glu Thr Leu Lys Asp Gln Leu Asp Phe Asn Gly Asn Val Leu 
            820                 825                 830         


Thr Leu Glu Lys Ile Thr Pro Trp Glu Ala Ser Pro Phe Lys Lys Pro 
        835                 840                 845             


Val Leu Cys His Thr Ile Ile Ser Ile Pro Phe Asn Thr Lys Gly Gly 
    850                 855                 860                 


His Thr Asp Lys Asp Tyr Val Asp Phe Ile Lys Asn Asn Phe Glu Gly 
865                 870                 875                 880 


Ser Tyr Asp Cys Glu Pro Asn Lys Ile Ile Leu Lys Tyr Lys Val Thr 
                885                 890                 895     


Ser Lys Asp Thr Lys Leu Lys Asp Ile Gly Lys Tyr Arg Met Tyr Ser 
            900                 905                 910         


His Asp Arg Arg Leu Pro Gly Leu Leu Ile Trp Lys Tyr Arg Pro Asn 
        915                 920                 925             


Asp Gln Asn Gly Asn Glu Ile Lys Phe Thr Glu Ile Glu Gln Glu Ile 
    930                 935                 940                 


Lys Ala Phe Glu Arg Arg Arg Ile Glu Ile Ala Gln Cys Leu Tyr Thr 
945                 950                 955                 960 


Leu Glu Lys Lys Val Ile Asp Ser Trp Phe Thr Gln Asp Glu Leu Gly 
                965                 970                 975     


Glu Glu His Ile Pro Phe Asn Lys Val Ile Asp Val Ile Lys Ala Lys 
            980                 985                 990         


Met Pro Asn Phe Glu Asp Lys Cys  Asn Val Leu Leu Lys  Ile Arg Asn 
        995                 1000                 1005             


Ala Ile  Asn His Asn Gln Phe  Pro Val Tyr Glu Gln  Ala Ile Gln 
    1010                 1015                 1020             


Thr Ala  Pro Gly Lys Glu Ile  Ala Gly Lys Met Leu  Arg Ile Thr 
    1025                 1030                 1035             


Glu Ser  Tyr Ile Glu Gln Ile  Met Ala Lys Ile Asp  Pro Asp Phe 
    1040                 1045                 1050             


Gly Arg  Thr Glu Asp Ala Glu  Ser Ser Arg 
    1055                 1060             


<210>  1653
<211>  1119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1653

Met Thr Glu Gln Asn Glu Lys Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Thr His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Met Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val His Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Tyr Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Gly Thr Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Thr Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Ile Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Phe Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Glu Glu Ala 
            500                 505                 510         


Ser Ala Glu Lys Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Asp Glu Ile Asp Thr Leu Asp 
    530                 535                 540                 


Arg Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Glu Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Ser Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Tyr Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Leu Ala Lys Leu Lys Lys Glu Ile Leu Glu Ala 
        835                 840                 845             


Lys Glu His Pro Tyr Leu Asp Phe Lys Ser Trp Gln Lys Phe Glu Arg 
    850                 855                 860                 


Glu Leu Arg Leu Val Lys Asn Gln Asp Ile Ile Thr Trp Met Met Cys 
865                 870                 875                 880 


Arg Asp Leu Met Glu Glu Asn Met Val Glu Gly Leu Asp Thr Gly Thr 
                885                 890                 895     


Leu Tyr Leu Lys Asp Ile Arg Thr Asp Val Gln Glu Gln Gly Ser Leu 
            900                 905                 910         


Asn Val Leu Asn Arg Val Lys Pro Met Arg Leu Pro Val Val Val Tyr 
        915                 920                 925             


Arg Ala Asp Ser Arg Gly His Val His Lys Glu Glu Ala Pro Leu Ala 
    930                 935                 940                 


Thr Val Tyr Ile Glu Glu Arg Asp Thr Lys Leu Leu Lys Gln Gly Asn 
945                 950                 955                 960 


Phe Lys Ser Phe Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe 
                965                 970                 975     


Val Asp Thr Gly Gly Leu Ala Met Glu Gln Tyr Pro Ile Ser Lys Leu 
            980                 985                 990         


Arg Val Glu Tyr Glu Leu Ala Lys  Tyr Gln Thr Ala Arg  Val Cys Ala 
        995                 1000                 1005             


Phe Glu  Gln Thr Leu Glu Leu  Glu Glu Ser Leu Leu  Thr Arg Tyr 
    1010                 1015                 1020             


Pro His  Leu Pro Asp Lys Asn  Phe Arg Lys Met Leu  Glu Ser Trp 
    1025                 1030                 1035             


Ser Asp  Pro Leu Leu Asp Lys  Trp Pro Asp Leu His  Arg Lys Val 
    1040                 1045                 1050             


Arg Leu  Leu Ile Ala Val Arg  Asn Ala Phe Ser His  Asn Gln Tyr 
    1055                 1060                 1065             


Pro Met  Tyr Asp Glu Ala Val  Phe Ser Ser Ile Arg  Lys Tyr Asp 
    1070                 1075                 1080             


Pro Ser  Ser Leu Asp Ala Ile  Glu Glu Arg Met Gly  Leu Asn Ile 
    1085                 1090                 1095             


Ala His  Arg Leu Ser Glu Glu  Val Lys Gln Ala Lys  Glu Met Val 
    1100                 1105                 1110             


Glu Arg  Ile Ile Gln Ala 
    1115                 


<210>  1654
<211>  1108
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1654

Met Thr Leu Lys Tyr Lys Glu Pro Ser Ser Leu Lys Pro Val Leu Gly 
1               5                   10                  15      


Ala Tyr Ala Ala Met Ala Arg Asn Asn Ala Phe Leu Thr Val Met Asp 
            20                  25                  30          


Ile Met Asp Gln Ile His Val Arg Gln Lys Glu Leu Phe Asp Arg Asn 
        35                  40                  45              


Gly Lys Lys Ala Asp Pro Glu Ser Ser Ile Trp Met Leu Asp Leu Phe 
    50                  55                  60                  


Pro Arg Asn Gly Arg Leu Leu Pro Glu Gln Glu Ala Arg Ala Ser Arg 
65                  70                  75                  80  


Leu Leu Arg Ser His Phe Pro Phe Leu Asp Leu Thr Ala Asp Leu Arg 
                85                  90                  95      


Asp Thr Glu Asp Gly Gln Gly Ser Val Ile Lys Gly Asn Cys Ser Tyr 
            100                 105                 110         


Glu Asp Leu Cys Gly Ala Phe Leu Ala Ile Ile Glu Val Leu Thr His 
        115                 120                 125             


Leu Arg Asp Val Asn Leu His Tyr Lys Ile Asn Asp Glu Lys Val Ser 
    130                 135                 140                 


Asp Phe Tyr Phe Arg Arg Ala Glu Val Gln Ser Gly Leu Ile Leu Arg 
145                 150                 155                 160 


Asp Ile Leu Lys Ala Ala Pro Arg Lys Ile Lys Asp Arg Phe Arg Gly 
                165                 170                 175     


Thr Asp Leu Leu Asp Glu Asp Ser Met Arg Phe Phe Leu Asn Asp Asn 
            180                 185                 190         


Tyr Ile Arg Gln Gly Lys Lys Tyr Thr Phe Asn His Arg Trp Glu Phe 
        195                 200                 205             


Asn Pro Gln Arg Arg Pro Leu Pro Ser Glu Gly Arg Val Leu Lys Gly 
    210                 215                 220                 


Gly Gln Pro Val Ile Asp Lys Phe Thr Gly Lys Pro Arg Ser Phe Glu 
225                 230                 235                 240 


Arg Leu Ser Ala Phe Gly Glu Ile Leu Leu Ile Ala Leu Phe Thr Glu 
                245                 250                 255     


Lys Arg Tyr Ile Pro Asp Phe Leu Arg Asp Cys Gly Phe Asp Glu Asn 
            260                 265                 270         


Phe Glu Ser Ser Ala Pro Asp Gly Lys Met Ser Arg Gln Arg Ile Ala 
        275                 280                 285             


Arg Glu Ile Ile Ser Ala Tyr Ser Ile Arg Leu Pro Glu Arg Lys Leu 
    290                 295                 300                 


Asp Ile Glu Ala Gly Ala Thr Gln Ile Met Leu Asp Met Leu Asn Glu 
305                 310                 315                 320 


Leu Ser Arg Cys Pro Ser Glu Leu Tyr Asp Val Leu Pro Glu Asn Glu 
                325                 330                 335     


Lys Arg Ala Phe Asp Ile Thr Gly Ser Asp Gly Ser Pro Val Leu Met 
            340                 345                 350         


Lys Arg Tyr Ser Asp Arg Tyr Val Pro Gln Val Leu Lys Tyr Phe Asp 
        355                 360                 365             


Thr Thr Glu Ala Phe Lys Thr Leu Arg Phe Gln Val Asn Thr Gly Gln 
    370                 375                 380                 


Leu Arg Tyr Glu Phe His Gly Leu Lys Glu Tyr Met Asp Gly Val Gly 
385                 390                 395                 400 


Arg Ile Arg Ile Val Gln Glu Gly Ile Asn Gly Phe Gly Arg Ile Gln 
                405                 410                 415     


Glu Met Glu Ala Met Arg Thr Gly Ser Asp Ser Tyr Leu Gly Phe Pro 
            420                 425                 430         


Leu Leu Glu Thr Asp Glu Asp Gly Lys Met Thr Asp Met Pro Tyr Ile 
        435                 440                 445             


Thr Asp Ser Ala Ala Arg Tyr Val Leu Asn Gly Asp Leu Ile Gly Leu 
    450                 455                 460                 


Ser Val Asn Gly Asp Ser Leu Pro Val Ile Glu Thr Val Thr Ala Gly 
465                 470                 475                 480 


Ala Asp Thr Arg Tyr Lys Val Arg Asn Arg Gln Pro Asp Cys Trp Leu 
                485                 490                 495     


Ser Arg Phe Glu Leu Pro Ala Leu Ala Phe Tyr Ser Tyr Leu Ser Arg 
            500                 505                 510         


Lys His His Val Lys Pro Thr Ala Glu Asp Ile Ile Ala Asp Ala Val 
        515                 520                 525             


Arg Asp Tyr Arg Asp Phe Phe Ser Gly Val Ala Glu Gly Arg Ile Thr 
    530                 535                 540                 


Ser Met Asp Gly Val Arg Ile Pro Arg Asn Gly Ile Pro Asp Lys Leu 
545                 550                 555                 560 


Leu His Tyr Leu Glu Gly Thr Pro Glu Ala Ser Gly Phe Gln Glu Phe 
                565                 570                 575     


Lys Glu Ser Val Val Ser Arg Leu Val Thr Asp Thr Gln Glu Arg Leu 
            580                 585                 590         


Ser His Leu Lys Thr Asp Leu Glu Thr Met Glu Ala Arg Asp Asn Lys 
        595                 600                 605             


Ile Gly Lys Arg Ser Phe Val Arg Ile Arg Pro Gly Lys Leu Ala Glu 
    610                 615                 620                 


Phe Leu Ala Glu Asp Ile Val Arg Phe Gln Gly Tyr His Glu Gly His 
625                 630                 635                 640 


Pro Glu Ala Arg Leu Thr Gly Gln Gln Tyr Ser Val Leu Gln Gly Met 
                645                 650                 655     


Leu Ala Thr Phe Ala Asp Gly Leu Gln Ala Ala Cys Arg Arg Ala Gly 
            660                 665                 670         


Leu Met Asp Gly Asp Ser Ala His Pro Phe Leu Ser Arg Val Phe Ser 
        675                 680                 685             


Leu His Gly Gln Gly Met Ala Ser Thr Val Asp Phe Tyr Arg Ala Tyr 
    690                 695                 700                 


Leu Glu Glu Arg Leu Ala Tyr Leu Lys Gly Ala Ile Pro Asp Thr Ala 
705                 710                 715                 720 


Pro Phe Leu His Pro Glu Arg Lys Lys Trp Thr Ala Glu Lys Asp Ala 
                725                 730                 735     


Val Tyr Tyr Arg Ala Leu Ala Gly Arg Tyr Leu Lys Asp Glu Lys Thr 
            740                 745                 750         


Gly Glu Asp Val Gly Ile Phe Leu Pro Arg Gly Leu Phe Glu Lys Pro 
        755                 760                 765             


Val Leu Asp Ile Ile Asn Ala Tyr Cys Pro Lys Thr Ala Asp Val Ile 
    770                 775                 780                 


Arg Lys Ala Glu Arg Ala Asn Met Ala Phe Ile Ile Leu Thr Tyr Ile 
785                 790                 795                 800 


Glu Asn Glu Leu Asp Asp Gln Asn Gln Gly Phe Tyr Tyr Glu Glu Gly 
                805                 810                 815     


Arg Leu Lys Glu Tyr Gly Phe Cys Arg Lys Val Ala Lys Glu Lys Glu 
            820                 825                 830         


Glu His Gly Pro Arg Arg Leu Tyr Ser Ile Leu Arg Lys Glu Lys Glu 
        835                 840                 845             


Ala His Pro Asp Gly Leu Tyr Phe Lys Ala Leu Lys Glu Glu Val Gly 
    850                 855                 860                 


Gly Phe Arg Asp Asp Gly Arg Lys Ala Ala Pro Leu Asp Arg Asp Thr 
865                 870                 875                 880 


Glu Thr Leu Ala Gly Glu Leu Lys Lys Ser Tyr Arg Arg Met Cys Asp 
                885                 890                 895     


Asn Glu Lys Ala Ile Arg Arg Tyr Met Val Gln Asp Ile Thr Met Phe 
            900                 905                 910         


Leu Leu Ala Arg Ser Leu Val Ser Lys Ala Gly Gly Ser Val Asn Leu 
        915                 920                 925             


Trp Ser Val Gly Pro Glu Gly Lys Gly Leu Leu Asp Gln Arg Val Asp 
    930                 935                 940                 


Val Val Thr Arg Phe Arg Lys Tyr Leu Ile Arg Gln Glu Gly Ile Lys 
945                 950                 955                 960 


Ile Lys Asp Tyr Gly Glu Ile Tyr Lys Ile Leu Lys Asp Lys Arg Ile 
                965                 970                 975     


Asp Thr Leu Leu Leu Ser Gln Asp Arg Asp Gly Asp Lys Val Val Gln 
            980                 985                 990         


Leu Glu Asp Ile Lys Glu Glu Leu  Val Thr Tyr Asn Arg  Lys Arg Ala 
        995                 1000                 1005             


Pro Val  Val Lys Thr Ile Gln  Glu Tyr Glu Lys Gly  Val Tyr Glu 
    1010                 1015                 1020             


Ala Asn  Ser Asp Leu Phe Ala  Gly Lys Gly Glu Arg  Phe Gly Phe 
    1025                 1030                 1035             


Lys Asp  Ile Leu Glu Ala Asp  Arg Glu Ser Ser Pro  Leu Lys Lys 
    1040                 1045                 1050             


Glu Ala  Ile Arg Gln Val Arg  Asn Ala Phe Ser His  Asn Gln Tyr 
    1055                 1060                 1065             


Pro Lys  Arg Thr Val Ser Thr  Gly Glu Gly Arg Met  Glu Leu Phe 
    1070                 1075                 1080             


Lys Pro  Asp Leu Pro Asn Met  Ala Lys Glu Ile His  Glu Asn Thr 
    1085                 1090                 1095             


Gly Lys  Leu Ile Asn Gly Glu  Lys Glu Ser 
    1100                 1105             


<210>  1655
<211>  1175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1655

Met Thr Glu Gln Asn Glu Lys Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Phe Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Ala His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Cys Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Glu Lys Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Ala Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Phe Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Asp Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Gly Glu Ile Asp Thr Leu Asp 
    530                 535                 540                 


Arg Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Met Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Gly Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Tyr Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Trp Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Asp Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Asp Leu Glu Ala Trp Ser His Ser Ala Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Ala Gly Ile Glu Tyr Ala Ser Pro Gly Asn 
    850                 855                 860                 


Lys Lys Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Glu Thr 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Lys Ala Asp Lys Ile Asn Ile Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Ala Gln Glu His Pro Tyr Leu Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asp Ile Arg Thr 
945                 950                 955                 960 


Glu Val Gln Glu Gln Gly Ser Leu Asn Val Leu Asn Arg Val Lys Pro 
                965                 970                 975     


Met Arg Leu Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val 
            980                 985                 990         


His Lys Glu Gln Ala Pro Leu Ala  Thr Val Tyr Ile Glu  Glu Arg Asp 
        995                 1000                 1005             


Thr Lys  Leu Leu Lys Gln Gly  Asn Phe Lys Ser Phe  Val Lys Asp 
    1010                 1015                 1020             


Arg Arg  Leu Asn Gly Leu Phe  Ser Phe Val Asp Thr  Gly Gly Leu 
    1025                 1030                 1035             


Ala Met  Glu Gln Tyr Pro Ile  Ser Lys Leu Arg Val  Glu Tyr Glu 
    1040                 1045                 1050             


Leu Ala  Lys Tyr Gln Thr Ala  Arg Val Cys Val Phe  Glu Gln Thr 
    1055                 1060                 1065             


Leu Glu  Leu Glu Glu Ser Leu  Leu Thr Arg Cys Pro  His Leu Pro 
    1070                 1075                 1080             


Asp Lys  Asn Phe Arg Lys Met  Leu Glu Ser Trp Ser  Asp Pro Leu 
    1085                 1090                 1095             


Leu Asp  Lys Trp Pro Asp Leu  His Gly Asn Val Arg  Leu Leu Ile 
    1100                 1105                 1110             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1115                 1120                 1125             


Glu Ala  Val Phe Ser Ser Ile  Arg Lys Tyr Asp Pro  Ser Ser Leu 
    1130                 1135                 1140             


Asp Ala  Ile Glu Glu Arg Met  Gly Leu Asn Ile Ala  His Arg Leu 
    1145                 1150                 1155             


Ser Glu  Glu Val Lys Gln Ala  Lys Glu Met Val Glu  Arg Ile Ile 
    1160                 1165                 1170             


Gln Val  
    1175 


<210>  1656
<211>  1199
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1656

Met Asn Thr Phe Ile Asp Ser Phe Ile Arg Arg Val Gln Ile Gln Asn 
1               5                   10                  15      


Gln Asn Gln Ser Trp Pro Lys Arg Pro Lys Tyr Val Arg Pro Val Glu 
            20                  25                  30          


Asn Ile Arg Pro Asp Asp Leu Ala Phe Gln Ser His Phe Thr Ala Tyr 
        35                  40                  45              


Leu Asn Met Ala Arg Gln Asn Cys Cys Ile Ile Leu Gly His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Gly Phe Lys Ala Ser Ser Val Lys Asp Thr Thr Leu Thr 
65                  70                  75                  80  


Ser Ser Pro Leu Leu Gly Gln Asn Gly Leu Leu Ser Pro Lys Lys Glu 
                85                  90                  95      


Val Ser Asp Leu Ile Arg Gly Arg Leu Leu Ser Ala Phe Pro Met Leu 
            100                 105                 110         


Asp Pro Met Ile Arg Tyr Arg Lys Ala Val Asp Lys Glu Lys Asp Asp 
        115                 120                 125             


Tyr Ala Arg Ile Ile Ile Thr Ser Glu Asp Val Ser Glu Met Leu Arg 
    130                 135                 140                 


Asp Leu Leu Asp Val Leu Ser Tyr Tyr Arg Asp Met Ala Ser His Val 
145                 150                 155                 160 


Val Phe Asn Asp Asp Arg Ser Val Ser Ala Glu Phe Ala Ser Lys Glu 
                165                 170                 175     


Lys Lys Val Ala Glu Cys Leu Asn Tyr Met Met Thr Val Ser Leu Arg 
            180                 185                 190         


Ile Val Lys Asp Arg Phe Ser Leu Ala Val Ser Asp Leu Asp Phe Tyr 
        195                 200                 205             


Asn Arg Asn Arg Tyr Met Met Val Asn Arg Lys Pro Leu Leu Asn Ala 
    210                 215                 220                 


Gly Phe Ala His Ala Val Arg Thr Glu Asp Tyr Arg Leu Thr Leu Met 
225                 230                 235                 240 


Gly Leu Val Leu Leu Cys Cys Gln Phe Ile Glu Lys Gln Tyr Ala Ser 
                245                 250                 255     


Met Phe Phe Asp Ala Leu Asp Lys His Ser Asn Gly Ala Arg Phe Tyr 
            260                 265                 270         


Gly Ile Ala Asp Ala Met Pro Met Val Asn Val Gly Thr Lys Asp Lys 
        275                 280                 285             


Pro Lys Lys Ile Pro Met Tyr Thr Gly Asp Glu Ala Gln Lys Gln Val 
    290                 295                 300                 


Gln Lys Gln Arg Met Ala Leu Arg Glu Ala Tyr Ser Val Tyr Arg Val 
305                 310                 315                 320 


Arg Ile Pro Lys Glu Arg Leu Glu Ser Thr Arg Ser Asp Met Ala Leu 
                325                 330                 335     


Ala Leu Asp Ile Leu Asn Glu Leu Gly Lys Cys Pro Glu Glu Leu Phe 
            340                 345                 350         


Glu His Leu Ser Pro Glu Asp Arg Glu Ser Phe Lys Asn Glu Glu Gly 
        355                 360                 365             


Val Leu Met Lys Arg Tyr Ser Asp Arg Phe Pro Gln Leu Ala Leu Arg 
    370                 375                 380                 


Trp Leu Asp Glu Asn Glu Lys Phe Asn Asn Leu Arg Phe His Val Thr 
385                 390                 395                 400 


Phe Gly Lys Tyr Arg Trp Leu Phe Cys Gln Asp Lys Lys Cys Ala Asp 
                405                 410                 415     


Gly Ser Val Arg Pro Arg Trp Leu Gln Lys Glu Leu Asn Gly Phe Gly 
            420                 425                 430         


Arg Ile Gln Thr Val Glu Arg Lys Arg Thr Gly Leu Glu Pro Gly Trp 
        435                 440                 445             


Asp Gly Thr Gly Leu Ile Arg Lys Phe Glu Glu Val Val Thr Asp Glu 
    450                 455                 460                 


Val Gln Lys Glu Pro Tyr Ile Thr Asp Phe Arg Thr Gln Tyr Leu Phe 
465                 470                 475                 480 


Asn Arg Asp Lys Ile Gly Ile Ser Leu Ser Glu Tyr Met Pro Gly Ile 
                485                 490                 495     


Gly Asp Ile His Ser Gly Lys Glu Trp Gly Lys His Ala Gly Val Pro 
            500                 505                 510         


Asp Phe Tyr Leu Ser Val Tyr Asp Ile Pro Ala Met Leu Phe Leu Thr 
        515                 520                 525             


Trp Leu Leu Gly Lys Asn Ser Ser Ala Val Glu Lys Leu Leu Ala Asn 
    530                 535                 540                 


Cys Lys Ala Ala Tyr Met Lys Leu Phe Asp Asp Leu Ala Lys Gly Lys 
545                 550                 555                 560 


Trp Glu Gly Glu Arg Asn Val Ser Asp Tyr Cys Ala Gly Glu Gly Thr 
                565                 570                 575     


Val Arg Tyr Thr Leu Arg Trp Tyr Asp Val Pro Met Lys Ile Arg Arg 
            580                 585                 590         


Lys Met Pro Leu Leu Gly Gly Asp Arg Asp Phe Glu Glu Lys Lys Ser 
        595                 600                 605             


Phe Glu Thr Leu Ala Gln Glu Ala Leu Thr Arg Met Leu Gln Arg Thr 
    610                 615                 620                 


Glu Asn Gln Leu Glu Lys Phe Asp Arg Asp Leu Ala Ala Ala Arg Asp 
625                 630                 635                 640 


Leu Lys Ala Asn Lys Gln Gly Lys Asp Arg Phe Val Asp Ile Arg Ala 
                645                 650                 655     


Gly Ser Leu Ala Thr Phe Leu Ala Arg Asp Ile Val Arg Leu Met Pro 
            660                 665                 670         


Val Ser Asp Asn Gly Arg Asn Lys Pro Thr Gly Leu Asn Tyr Ser Ile 
        675                 680                 685             


Val Gln Lys Ala Ile Ala Thr Tyr Lys Pro Ser Glu Gly Gly Leu Asp 
    690                 695                 700                 


Thr Leu Thr Gly Val Phe Arg Asp Ala Arg Ile Ile Gly Val Lys Gly 
705                 710                 715                 720 


Gly Ser His Pro Phe Leu Glu Arg Leu Leu Val Glu Lys Lys Pro Ser 
                725                 730                 735     


Ser Val Leu Ala Leu Tyr Arg His Tyr Leu Glu Tyr Arg Lys Glu Tyr 
            740                 745                 750         


Leu Lys Lys Ala Leu Glu Asp Glu Asn Lys Ala Glu Leu Lys Asn Leu 
        755                 760                 765             


Pro Phe Leu Lys Ser Gly Arg Gln Lys Tyr Ala Val Asp Gln Ala Asp 
    770                 775                 780                 


Tyr Ala Arg Arg Leu Ala Glu Ser Tyr Arg Asn Cys Pro Ile Tyr Leu 
785                 790                 795                 800 


Pro Thr Gly Ile Phe Thr Asp Met Leu Lys Asp Gln Leu Ala Lys Ile 
                805                 810                 815     


Asp Val Met Lys Pro Val Leu Glu Asn Asp Lys Val Asn Ala Ser Tyr 
            820                 825                 830         


Leu Ile Ala Gln Tyr Phe Glu Lys Val Glu His Asp Ser Glu Gln Pro 
        835                 840                 845             


Leu Tyr Arg Leu Lys Arg Asn Tyr Arg Val Phe Asp Leu Leu Glu Phe 
    850                 855                 860                 


Thr Asp Glu Pro Lys Tyr Trp Arg Leu Asn Glu Arg Ser Asp Lys Ala 
865                 870                 875                 880 


Gly Lys Tyr Gly Leu Ala Lys Arg Asn Ile Phe Trp Asn Arg Met Gly 
                885                 890                 895     


Glu Tyr Tyr Lys Gly Leu Lys Lys Phe Tyr Lys Gly Tyr Glu Ser Lys 
            900                 905                 910         


Arg Thr Ala Val Asp Trp Arg Glu Lys Leu Lys Ile Val Glu Ala Glu 
        915                 920                 925             


His Ala Met Trp Asn Arg Leu Lys Asp Ala Ser Gly Glu Ala Arg Leu 
    930                 935                 940                 


Lys Met Lys Asp Gly Val Phe Tyr Ser Arg Leu Leu Ser Ala Arg Lys 
945                 950                 955                 960 


Glu Tyr Asp Asp Cys Glu Arg Ala Leu Arg Arg Leu Lys Val Gln Asp 
                965                 970                 975     


Ile Val Leu Phe Leu Ala Ala Arg Glu Thr Leu Ile Leu Pro Lys Asp 
            980                 985                 990         


Lys Val Phe Arg Leu Lys Asn Leu  Ser Leu Ser Glu Gly  Asn Lys Asn 
        995                 1000                 1005             


Ile Leu  Ser Ser Ala Ile Asp  Glu Phe Ser Val Asp  Val Val Trp 
    1010                 1015                 1020             


Thr Glu  Lys Glu Gly Ala Ala  Lys Val Thr His Ser  Ala Ser Ile 
    1025                 1030                 1035             


Lys Glu  Asn Asp Val Val Ile  Lys Asn Tyr Gly Arg  Met Phe Arg 
    1040                 1045                 1050             


Leu Leu  His Asp Asp Arg Val  Lys Thr Leu Leu Pro  His Ile Tyr 
    1055                 1060                 1065             


Asp Ser  Ala Leu Ser Glu Asn  Ile Thr Gly Asp Arg  Ile Thr Val 
    1070                 1075                 1080             


Lys Asp  Asn Lys Val Ile Ile  Asp Lys Ser Leu Phe  Asp Glu Asp 
    1085                 1090                 1095             


Leu Met  Asn Tyr Asp Leu Arg  Arg His Glu Ile Cys  Glu Ile Ile 
    1100                 1105                 1110             


Leu Arg  Phe Glu Ala Ala Ser  Ile Lys Arg Phe Gly  Leu Asp Gly 
    1115                 1120                 1125             


Arg Val  Asp Phe Lys Ala Ala  Leu Asp Ala Leu Thr  Gly Arg Ser 
    1130                 1135                 1140             


Leu Leu  Asn Asp Glu Asp Ala  Arg Ile Leu Ser Ala  Ile Arg Asn 
    1145                 1150                 1155             


Ala Tyr  Asn His Asn Lys Tyr  Pro Ala Lys Gly Thr  Asp Val Lys 
    1160                 1165                 1170             


Val Asn  Val Met Ala Leu Pro  Lys Leu Thr Glu Asp  Leu Leu Arg 
    1175                 1180                 1185             


Ile Phe  Ser Asp Thr Gly Asn  Asn Arg Val Arg 
    1190                 1195                 


<210>  1657
<211>  1253
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1657

Met Leu Glu Ile Gln Ile Glu Lys Glu Lys Arg Gly Trp Phe Trp Ala 
1               5                   10                  15      


Met Asn Leu Thr Met Ala Leu Asn Asn Leu Glu Thr Ile Ala Lys Arg 
            20                  25                  30          


Ala Leu Asn Val Leu Gly Lys Pro Tyr Pro Ala Ser Gln Ser Glu Asp 
        35                  40                  45              


Glu Gln Thr Asn Ala Leu Lys Gln Ala Leu Asp Glu Leu Gln Lys Gln 
    50                  55                  60                  


Pro Leu Ile Cys Gln Thr Lys Ile Glu Arg Val Phe Phe Arg Ser Leu 
65                  70                  75                  80  


Pro His Leu Asn Lys Phe Arg Gln Phe Ile Glu Met Gly Gly Glu Lys 
                85                  90                  95      


Ser Ser Ala Ser Tyr Val Glu Lys Ser Ser Ser Arg Ala Asp Ala Glu 
            100                 105                 110         


Ala Thr Gln Arg Gln Ser Gly Arg Asp Phe Thr Ser Asp Asp Leu Phe 
        115                 120                 125             


Gln Leu Ala Arg Tyr Tyr Leu Lys Ser Leu Val Glu Leu Arg Asn Tyr 
    130                 135                 140                 


Phe Ala His Ser Glu His Gln Tyr Pro Lys Leu Pro Glu Ser Leu Asp 
145                 150                 155                 160 


Ile Lys Gly Val Arg Phe Pro Ser Ser Phe Glu Asn Ala Leu Phe Asn 
                165                 170                 175     


Ala Asn Val Arg Thr Val Lys Asp Arg Phe Tyr Lys Asp Asp Arg Lys 
            180                 185                 190         


Asp Ala Arg Glu Ile Glu Asn Gly Phe Leu Cys Phe Arg Pro Lys Lys 
        195                 200                 205             


Thr Val Lys Asn Arg Glu Thr Val Asp Asn Pro Glu Phe Lys Phe Arg 
    210                 215                 220                 


Leu Thr Glu Arg Asn Asp Ala Asn Gly Arg Arg Tyr Pro Thr Gln Ala 
225                 230                 235                 240 


Gly Leu Ala Phe Phe Val Ala Arg Phe Leu Glu Lys Arg Tyr Val Asp 
                245                 250                 255     


Leu Leu Phe Glu Thr Thr Asp Ala Asn Gly Val Pro Val Leu Pro Leu 
            260                 265                 270         


His Arg Pro Gln Asp Val Asp Gly Val Glu Phe Ser Leu Ala Pro Arg 
        275                 280                 285             


Arg Val Tyr Gly Leu Asn Ala Ala Arg Leu Pro Arg Arg Arg Val Glu 
    290                 295                 300                 


Thr Thr Ala Arg Pro Glu Ser Ser Asn Glu Thr Leu Gly Leu Asp Leu 
305                 310                 315                 320 


Ile Gly Tyr Leu Ala Arg Cys Pro Lys Arg Val Tyr Glu Phe Leu Ser 
                325                 330                 335     


Glu Thr Asp Arg Arg Lys Phe Arg Val Ala Ala Asp Glu Ser Asn Pro 
            340                 345                 350         


Ser Glu Gly Leu Arg Thr Arg Ser Glu Lys Arg Phe Ala Arg Leu Ala 
        355                 360                 365             


Ala Leu Cys Leu Asp Arg Met Asn Cys Phe Glu Asn Leu Arg Phe Gln 
    370                 375                 380                 


Val Asp Met Gly Gln Tyr Tyr Ser Ala Thr His Arg Arg Arg Leu Ile 
385                 390                 395                 400 


Asp Gly Thr Thr Ile Asp Asp Arg Arg Val Gly Lys Arg Val Phe Trp 
                405                 410                 415     


Phe Glu Arg Ile Gln Asn Ala Val Asp Tyr Tyr Arg Ala Glu Arg Leu 
            420                 425                 430         


Lys Pro Glu Ser Lys Tyr Phe Val Pro Thr Asp Glu Ala Glu Thr Pro 
        435                 440                 445             


Pro Glu Thr Asp Tyr Arg Val Asp Ala Tyr Pro Arg Tyr Arg Val Lys 
    450                 455                 460                 


Asn Gln Gln Leu Gly Leu Arg Leu Val Asp Ala Ser Gln Lys Asn Ala 
465                 470                 475                 480 


Pro Pro Lys Leu Ile Pro Trp Thr His Ser Ala Lys Arg Gly Ser Ala 
                485                 490                 495     


Pro Lys Thr Arg Met Lys Arg Pro Glu Phe Trp Leu Ser Gln Tyr Glu 
            500                 505                 510         


Leu Pro Ala Leu Leu Phe Val Ala Leu His Gly Lys Ala Gln Asp Ala 
        515                 520                 525             


Gln Asn Val Ile Ala Asp Tyr Gln Lys Asn Trp Arg Arg Phe Leu Glu 
    530                 535                 540                 


Asp Val Arg Asp Gly Lys Phe Asp Phe Gly Gly Gly Arg Ala Leu Arg 
545                 550                 555                 560 


Glu Thr Arg Gln Thr Phe Glu Ser Gln Tyr Gly Leu Arg Phe Asp Asp 
                565                 570                 575     


Leu Pro Asp Ser Thr Arg Ala Leu Phe Arg Ser Thr Ala Ser Asp Ser 
            580                 585                 590         


Lys Glu Leu Glu Lys Lys Arg Val Asp Ala Ala Glu Gln Thr Leu Pro 
        595                 600                 605             


Glu Arg Gln Ile Asp Arg Leu Leu Asp Glu Thr Arg Arg Arg Leu Ala 
    610                 615                 620                 


Val Leu Glu Ser Glu Thr Arg Glu Val Phe Gln Leu Gly Lys Arg Lys 
625                 630                 635                 640 


Arg Pro Ser Leu Ser Val Gly Arg Val Ala Ser Cys Leu Val Arg Asp 
                645                 650                 655     


Leu Met Arg Phe Gln Tyr Ala Thr Ser Glu Lys Ser Phe Gly Lys Ile 
            660                 665                 670         


Pro Ser Ser Pro Asp Phe Ile Ala Leu Gln Thr Ser Leu Ala Cys Phe 
        675                 680                 685             


Glu Ser Arg Gln Asn Glu Leu Leu Glu Ile Phe Lys Ala Ala Lys Leu 
    690                 695                 700                 


Ile Pro Ser Asn Phe Val Ala Pro Asn Asp Ala Glu Glu Ala Phe Phe 
705                 710                 715                 720 


Phe Ala Asp Ala Gln Asn Ala Glu Arg Ser Leu His Pro Phe Leu Gly 
                725                 730                 735     


Ala Val Val Ala Asp Ala Ala Asn Leu Arg Asp Trp Lys Ser Phe Tyr 
            740                 745                 750         


Arg Ala Tyr Leu Thr Cys Arg Leu Asn Trp Leu Arg Gly Cys Ala Pro 
        755                 760                 765             


Gln Glu Leu Arg His Thr Arg Tyr Gly Asn Arg Arg Leu Glu Lys Leu 
    770                 775                 780                 


Lys Lys Met Arg Lys Ser Gly Lys Arg Gln Thr Val Ala Gln Gln Met 
785                 790                 795                 800 


Ala Thr Arg Leu Leu Glu Gln Pro Ile Asn Leu Pro Arg Gly Leu Phe 
                805                 810                 815     


Thr Asp Leu Val Arg Ala Val Val Gln Glu Arg Phe Gly Asp Gln Leu 
            820                 825                 830         


Ala Lys Ala Thr Gln Asn Gly Ala Thr Ser Thr Asn Ala Ser Trp Leu 
        835                 840                 845             


Ile Gly Lys Val Arg Asp Trp Ser Asp Asp Ala Ser Gln Gly Phe Tyr 
    850                 855                 860                 


Ser Trp Arg Arg Asp Tyr Arg Asn Val Ala Ser Phe Lys Arg Leu Phe 
865                 870                 875                 880 


Glu Leu Cys Gly Pro Thr Val Ser Thr Ser Pro Leu Ala Phe Arg Ala 
                885                 890                 895     


Leu Asn Ser Thr Ser Pro Leu Asp Phe Arg Ala Leu Lys Glu Ala Phe 
            900                 905                 910         


Asp Ala Asn Phe Asp Ala Asn Tyr Ala Ala Ala Glu Phe Ala Lys Thr 
        915                 920                 925             


Asp His Lys Thr Asp Arg Glu Asp Trp Glu Arg Phe Ile Arg Glu Ala 
    930                 935                 940                 


Glu Ala Glu Leu Arg Glu Glu Ala Leu Glu Ala Thr Arg Gly Arg Ser 
945                 950                 955                 960 


Gln Arg Arg Pro Phe Ile Pro Arg Glu Lys Ile Glu Glu Arg Ala Ser 
                965                 970                 975     


Lys Lys Arg Lys Lys Phe Ala Asp Glu Gln Lys Ala Lys Arg Arg Ala 
            980                 985                 990         


Ala Glu His Ala Lys Ile Arg Arg  Leu Ser Asp Ala Glu  Arg Asp Ile 
        995                 1000                 1005             


Arg His  Ala Glu Ile Gln Asp  Tyr Val Leu Leu Leu  Ala Ala Ser 
    1010                 1015                 1020             


Tyr Phe  Leu Phe Glu Gly Asp  Leu Ala Lys Ile Arg  Leu Ala Asp 
    1025                 1030                 1035             


Val Tyr  Ala Ile Val Asp Asp  Ala Thr Gly Thr Val  Ser Thr Asn 
    1040                 1045                 1050             


Pro Leu  Arg Lys Leu Arg Pro  Cys Glu Val Leu Val  Asp Val Pro 
    1055                 1060                 1065             


Gly Ser  Gly Thr Cys Lys Ile  Arg Gly Glu Met Asn  Val Lys Asn 
    1070                 1075                 1080             


Ser Gly  Asn Phe Gln Arg Phe  Leu Thr Asp Gly Arg  Leu Pro Ser 
    1085                 1090                 1095             


Phe Leu  Arg Ser Leu Arg Leu  Met Gln Ala Glu Asn  Ala Glu Glu 
    1100                 1105                 1110             


Leu Ser  Tyr Ile Asp Leu Ala  Asn Glu Phe Ala Ala  Ser Asp Arg 
    1115                 1120                 1125             


Leu Gln  Arg Gly Arg Ile Phe  Ala Ala Ile Tyr Arg  Phe Glu Asn 
    1130                 1135                 1140             


Ala Cys  Phe Ser Val Phe Pro  Glu Leu Lys Asp Lys  Lys Arg Gly 
    1145                 1150                 1155             


Gly Tyr  Val Ser Phe Ala Thr  Ile Leu Thr Ser Val  Phe Pro Asn 
    1160                 1165                 1170             


Asp Glu  Glu Thr Gln Tyr Arg  Leu Leu Val Ile Arg  Asn Lys Phe 
    1175                 1180                 1185             


Met His  Gln Glu Tyr Pro Ile  Tyr Asp Ala Ser Gln  Thr Lys Asp 
    1190                 1195                 1200             


Lys Gln  Arg Trp Thr Pro Ile  Phe Asp Arg Trp Asn  Arg Glu Met 
    1205                 1210                 1215             


Trp Ala  Lys Tyr Asp Pro Lys  His Gly Arg Ala Leu  Cys Gln Cys 
    1220                 1225                 1230             


Ala Val  Asp Trp Ala Glu Pro  Tyr Phe Asp Glu Ala  Thr Lys Leu 
    1235                 1240                 1245             


Val Glu  Ser Arg Arg 
    1250             


<210>  1658
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1658

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Ala Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Asn Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1659
<211>  1149
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1659

Met Met Glu Lys Glu Asn Val Gln Gly Ser His Ile Tyr Tyr Glu Pro 
1               5                   10                  15      


Thr Asp Lys Cys Phe Trp Ala Ala Phe Tyr Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Leu Thr Val Ala His Ile Asn Ser Phe Val Asn Ser Lys Lys 
        35                  40                  45              


Gly Ile Asn Asn Asp Asp Lys Val Leu Asp Val Ile Asp Ala Trp Ser 
    50                  55                  60                  


Lys Phe Asp Asn Asp Leu Leu Met Gly Ala Arg Leu Asn Lys Leu Ile 
65                  70                  75                  80  


Leu Lys His Phe Pro Phe Leu Lys Ala Pro Leu Tyr Lys Gln Thr Lys 
                85                  90                  95      


Lys Glu Ala Ser Lys Gln Tyr Lys Glu Glu Asn Pro Ser Ala Asp Lys 
            100                 105                 110         


Gln Lys Ile Glu Lys Glu Ser Ala Lys Thr Ala Met Ala Asn Thr Leu 
        115                 120                 125             


Glu Leu Glu Asn Val Arg Lys Thr Leu His Ala Phe Leu Gln Gln Leu 
    130                 135                 140                 


Glu Asp Leu Arg Asn His Phe Ser His Tyr Asn Tyr Asn Ser Pro Asp 
145                 150                 155                 160 


Glu Lys Thr Glu Val Lys Phe Asp Asp Gly Phe Cys Asn Lys Leu Tyr 
                165                 170                 175     


Tyr Val Phe Asp Ala Ala Leu Gln Met Val Lys Asp Asp Asn Arg Met 
            180                 185                 190         


Asn Pro Glu Ile Asn Met Gln Thr Asp Phe Glu His Leu Val Arg Leu 
        195                 200                 205             


Gly Pro Asn Gly Glu Ile Ser His Ser Phe Lys Tyr Lys Phe Ile Glu 
    210                 215                 220                 


Pro Asp Gly Thr Ile Asn Asn Asn Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Lys Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Asn Tyr Met Arg Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Asn Arg Met Val Ile Pro Lys Leu Arg Leu Glu Thr Asp Tyr 
        275                 280                 285             


Asp Asn His Gln Leu Met Phe Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Leu Ser Leu Tyr Lys Arg Leu Lys Lys Glu Asp Gln Asp Lys Phe 
305                 310                 315                 320 


Arg Val Pro Ile Glu Phe Leu Asp Glu Asp Asn Glu Ala Asp Asn Pro 
                325                 330                 335     


Tyr Gln Glu Asn Ala Asn Ser Asp Glu Asn Pro Thr Glu Glu Thr Asp 
            340                 345                 350         


Pro Leu Lys Asn Thr Leu Val Arg His Gln His Arg Phe Pro Tyr Phe 
        355                 360                 365             


Val Leu Arg Tyr Phe Asp Leu Asn Glu Val Phe Lys Gln Leu Arg Phe 
    370                 375                 380                 


Gln Ile Asn Leu Gly Cys Tyr His Phe Ser Ile Tyr Asp Lys Thr Ile 
385                 390                 395                 400 


Gly Glu Arg Thr Glu Lys Arg His Leu Thr Arg Thr Leu Phe Gly Phe 
                405                 410                 415     


Asp Arg Leu Gln Asn Phe Ser Val Lys Leu Gln Pro Gln His Trp Lys 
            420                 425                 430         


Asn Met Val Lys His Leu Asp Thr Glu Glu Ser Ser Asp Lys Pro Tyr 
        435                 440                 445             


Leu Ser Asp Ala Met Pro His Tyr Gln Ile Glu Asn Glu Lys Ile Gly 
    450                 455                 460                 


Ile His Phe Leu Lys Thr Asp Thr Glu Lys Lys Glu Thr Val Trp Pro 
465                 470                 475                 480 


Ser Leu Glu Val Glu Glu Val Ser Ser Asn Arg Asn Lys Tyr Lys Ser 
                485                 490                 495     


Glu Lys Asn Leu Thr Ala Asp Ala Phe Leu Ser Thr His Glu Leu Leu 
            500                 505                 510         


Pro Met Met Phe Tyr Tyr Gln Leu Leu Ser Ser Glu Glu Lys Thr Arg 
        515                 520                 525             


Ala Ala Ala Gly Asp Lys Val Gln Gly Val Leu Gln Ser Tyr Arg Lys 
    530                 535                 540                 


Lys Ile Phe Asp Ile Tyr Asp Asp Phe Ala Asn Gly Thr Ile Asn Ser 
545                 550                 555                 560 


Met Gln Lys Leu Asp Glu Arg Leu Ala Lys Asp Asn Leu Leu Arg Gly 
                565                 570                 575     


Asn Met Pro Gln Gln Met Leu Ala Ile Leu Glu His Gln Glu Pro Asp 
            580                 585                 590         


Met Glu Gln Lys Ala Lys Glu Lys Leu Asp Leu Leu Ile Thr Glu Thr 
        595                 600                 605             


Glu Glu Arg Ile Asp Lys Leu Asp Thr Gln Ser Lys Gln Lys Val Arg 
    610                 615                 620                 


Ile Gly Lys Arg Arg Ala Gly Leu Pro Lys Val Gly Ser Ile Ala Asp 
625                 630                 635                 640 


Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Ala Lys Arg Asn Ala 
                645                 650                 655     


Asp Asn Thr Gly Val Pro Asp Ser Lys Ala Asn Ser Thr Glu Tyr Arg 
            660                 665                 670         


Leu Leu Gln Glu Ala Leu Ala Phe Tyr Ser Ala Tyr Lys Asp Arg Leu 
        675                 680                 685             


Glu Pro Tyr Phe Arg Gln Val Asn Leu Ile Gly Asp Thr Asn Pro His 
    690                 695                 700                 


Pro Phe Leu His Asn Val Lys Trp Gln Lys Cys Thr His Leu Leu Ser 
705                 710                 715                 720 


Phe Tyr His Asp Tyr Leu Glu Ala Lys Lys Gln Tyr Leu Tyr His Leu 
                725                 730                 735     


Ser Pro Ala Asp Trp Gln Lys His Gln Tyr Phe Leu Leu Leu Lys Val 
            740                 745                 750         


Arg Lys Asp Ile Gln Asn Glu Lys Lys Asp Trp Lys Lys Ser Leu Val 
        755                 760                 765             


Ala Gly Trp Lys Asn Gly Phe Asn Leu Pro Arg Gly Leu Phe Thr Glu 
    770                 775                 780                 


Ser Ile Lys Thr Trp Phe Ser Thr His Ala Asp Lys Val Gln Ile Thr 
785                 790                 795                 800 


Asp Thr Lys Leu Phe Glu Asn Arg Val Gly Leu Ile Ala Lys Leu Ile 
                805                 810                 815     


Pro Leu Tyr Tyr Asp Lys Val Tyr Asn Asp Lys Pro Gln Pro Phe Tyr 
            820                 825                 830         


Gln Tyr Pro Phe Asn Ile Asn Asp Arg Tyr Lys Pro Glu Asp Thr His 
        835                 840                 845             


Lys Lys Phe Thr Ala Ala Ser Ser Glu Leu Trp Gln Lys Lys Lys Ala 
    850                 855                 860                 


Leu Tyr Lys Asn Val Gln Pro Asp Ser Ser Asn Lys Ile Glu Tyr Pro 
865                 870                 875                 880 


Gln Tyr Leu Asp Phe Leu Ser Trp Lys Lys Leu Glu Arg Glu Leu Arg 
                885                 890                 895     


Met Leu Arg Asn Gln Asp Met Met Val Trp Leu Met Cys Lys Asp Leu 
            900                 905                 910         


Phe Ala Gln Cys Thr Val Glu Gly Val Glu Phe Ala Asp Leu Lys Leu 
        915                 920                 925             


Ser Gln Leu Glu Val Asp Val Thr Val Gln Asn Asn Leu Asn Val Leu 
    930                 935                 940                 


Asn Asn Val Ser Ser Met Ile Leu Pro Leu Ser Val Tyr Pro Ser Asp 
945                 950                 955                 960 


Ala Gln Gly Asn Ile Leu Arg Asn Ser Lys Pro Leu Tyr Thr Val Tyr 
                965                 970                 975     


Val Gln Glu Asn Asn Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ser 
            980                 985                 990         


Leu Leu Lys Asp Arg Arg Leu Asn  Gly Leu Phe Ser Phe  Ile Thr Ala 
        995                 1000                 1005             


Glu Gly  Glu Asp Leu Gln Gln  His Pro Leu Thr Lys  Asn Arg Leu 
    1010                 1015                 1020             


Glu Tyr  Glu Leu Ser Ile Tyr  Gln Thr Met Arg Ile  Ser Val Phe 
    1025                 1030                 1035             


Glu Gln  Thr Leu Gln Leu Glu  Lys Ala Ile Leu Thr  Arg Asn Glu 
    1040                 1045                 1050             


Thr Leu  Cys Gly Asn Asn Phe  Asn Asn Leu Leu Asn  Ser Trp Ser 
    1055                 1060                 1065             


Glu His  Arg Thr Asp Lys Lys  Thr Leu Gln Pro Asp  Ile Asp Phe 
    1070                 1075                 1080             


Leu Ile  Ala Val Arg Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met 
    1085                 1090                 1095             


Ser Thr  Leu Glu Val Met Gln  Asp Ile Glu Lys Phe  Asn Ile Gln 
    1100                 1105                 1110             


Pro Pro  Lys Leu Glu Glu Lys  Asp Gly Leu Gly Ile  Ala Ser Gln 
    1115                 1120                 1125             


Leu Ala  Lys Lys Thr Lys Asp  Ala Ala Ser His Leu  Gln Asn Ile 
    1130                 1135                 1140             


Ile Tyr  Gly Gly Thr Asn 
    1145                 


<210>  1660
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1660

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Ala Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Asn Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1661
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1661

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Ile Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1662
<211>  1090
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1662

Met Asn Ile Pro Ala Leu Val Glu Asn Gln Lys Lys Tyr Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Val Met Ala Met Leu Asn Ala Gln Thr Val Leu Asp His Ile 
            20                  25                  30          


Gln Lys Val Ala Asp Ile Glu Gly Glu Gln Asn Glu Asn Asn Glu Asn 
        35                  40                  45              


Leu Trp Phe His Pro Ile Met Ser His Leu Tyr Asn Ala Lys Asn Gly 
    50                  55                  60                  


Tyr Asp Lys Gln Pro Glu Lys Thr Met Phe Ile Ile Glu Arg Leu Gln 
65                  70                  75                  80  


Ser Tyr Phe Pro Phe Leu Lys Ile Met Ala Glu Ser Gln Arg Glu Tyr 
                85                  90                  95      


Ser Asn Lys Lys Asn Lys Gln Asn Arg Val Glu Val Asn Ser Asn Asp 
            100                 105                 110         


Ile Phe Glu Val Leu Lys Arg Ala Phe Gly Val Leu Lys Met Tyr Arg 
        115                 120                 125             


Asp Gln Thr Asn His Tyr Lys Thr Tyr Asp Glu Lys Leu Ile Asp Gly 
    130                 135                 140                 


Cys Glu Phe Leu Thr Arg Thr Glu Leu Pro Leu Ser Gly Met Ile Asn 
145                 150                 155                 160 


Ser Tyr Tyr Thr Val Ala Leu Arg Asn Ile Lys Glu Arg Tyr Gly Tyr 
                165                 170                 175     


Lys Thr Glu Asp Leu Ala Phe Ile Gln Asp Asn Arg Tyr Lys Phe Val 
            180                 185                 190         


Lys Asp Ala Tyr Gly Lys Arg Lys Ser Gln Val Asn Thr Gly Phe Phe 
        195                 200                 205             


Leu Ser Leu Gln Asp Tyr Asn Gly Asp Met Thr Lys Lys Leu His Leu 
    210                 215                 220                 


Ser Gly Val Gly Ile Ala Leu Leu Ile Cys Leu Phe Leu Asp Lys Gln 
225                 230                 235                 240 


Tyr Ile Asn Leu Phe Leu Ser Arg Leu Pro Ile Phe Ser Ser Tyr Asn 
                245                 250                 255     


Ala Gln Ser Glu Glu Arg Arg Ile Ile Ile Arg Ser Phe Gly Ile Asn 
            260                 265                 270         


Ser Ile Lys Gln Pro Lys Asp Arg Ile His Ser Glu Lys Ser Asn Lys 
        275                 280                 285             


Ser Val Ala Met Asp Met Leu Asn Glu Val Lys Arg Cys Pro Asp Glu 
    290                 295                 300                 


Leu Phe Thr Thr Leu Ser Ala Glu Lys Gln Ser Arg Phe Arg Ile Ile 
305                 310                 315                 320 


Ser Asp Asp His Asn Glu Val Leu Met Lys Arg Ser Ser Asp Arg Phe 
                325                 330                 335     


Val Gln Leu Leu Leu Gln Tyr Ile Asp Tyr Gly Lys Leu Phe Lys Asn 
            340                 345                 350         


Ile Arg Phe His Val Asn Met Gly Lys Leu Arg Tyr Leu Leu Lys Ala 
        355                 360                 365             


Asp Lys Glu Cys Ile Asp Gly Gln Thr Arg Val Arg Val Ile Glu Gln 
    370                 375                 380                 


Pro Leu Asn Gly Phe Gly Arg Leu Asp Glu Val Glu Val Leu Arg Lys 
385                 390                 395                 400 


Gln Glu Asn Gly Thr Phe Gly Lys Ser Gly Ile Arg Ile Arg Asp Phe 
                405                 410                 415     


Glu Asn Met Lys Arg Asp Asp Asp Asn Pro Ala Asp Tyr Pro Tyr Ile 
            420                 425                 430         


Val Asp Thr Tyr Thr His Tyr Met Leu Glu Asn Asn Lys Val Glu Met 
        435                 440                 445             


Tyr Ile Ser Lys Asp Asp Asn Pro Ala Pro Leu Leu Pro Glu Ile Glu 
    450                 455                 460                 


Asp Asn Arg Tyr Ala Val Lys Thr Ile Pro Ser Cys Arg Ile Ser Thr 
465                 470                 475                 480 


Leu Glu Phe Pro Ala Met Ala Phe His Met Phe Leu Leu Gly Ser Glu 
                485                 490                 495     


Arg Thr Glu Arg Arg Ile Lys Asp Val Tyr Asp Arg Tyr Lys Lys Leu 
            500                 505                 510         


Phe Glu Ala Met His Lys Glu Glu Val Thr Ala Glu Asn Ile Ala Ser 
        515                 520                 525             


Phe Gly Ile Ala Glu Arg Asp Leu Pro Lys Lys Ile Leu Asp Ile Ile 
    530                 535                 540                 


Asn Gly Asn Ala Gln Gly Lys Asp Val Asp Ala Tyr Ile Lys Ala Thr 
545                 550                 555                 560 


Ile Asp Asn Met Ile Ala Asp Thr Glu His Arg Ile Lys Lys Leu Lys 
                565                 570                 575     


Asp Asp Arg Lys Ala Val Arg Ser Val Asp Asn Lys Met Gly Lys Arg 
            580                 585                 590         


Ser Phe Lys Arg Ile Ser Thr Gly Lys Leu Ala Asp Phe Leu Ala Lys 
        595                 600                 605             


Asp Ile Val Met Phe Gln Pro Ser Lys Asn Tyr Gly Glu Asn Lys Ile 
    610                 615                 620                 


Thr Gly Leu Asn Tyr Arg Ile Met Gln Ser Ala Ile Ala Val Tyr Asp 
625                 630                 635                 640 


Ser Gly Asp Asn Tyr Glu Ala Lys Gln Gln Phe Arg Leu Met Phe Glu 
                645                 650                 655     


Asn Ala Gln Leu Ile Gly Lys Gly Ile Thr Glu Ala His Pro Phe Leu 
            660                 665                 670         


Tyr Lys Val Phe Ala Arg Ser Val Pro Ala Asn Ala Val Asp Phe Tyr 
        675                 680                 685             


Glu Arg Tyr Leu Ile Glu Arg Lys Tyr Tyr Leu Thr Ala Leu Phe Asn 
    690                 695                 700                 


Glu Ile Lys Lys Gly Asn Lys Val Asp Ile Pro Phe Ile Arg Arg Asn 
705                 710                 715                 720 


Gln Asn Lys Trp Lys Thr Pro Val Met Lys Thr Leu Gly Arg Ile Tyr 
                725                 730                 735     


Asn Glu Asp Leu Pro Val Glu Leu Pro Arg Gln Met Phe Asp Asp Glu 
            740                 745                 750         


Ile Lys Ser His Leu Lys Ser Leu Ser Gln Met Ser Ser Ile Asp Phe 
        755                 760                 765             


Asp Asn Ala Asn Val Thr Tyr Leu Ile Ala Glu Tyr Met Lys Arg Val 
    770                 775                 780                 


Leu Gly Asp Asp Phe Gln Asn Phe Tyr Gln Trp Asn Arg Asn Tyr Arg 
785                 790                 795                 800 


Tyr Met Asp Met Leu Lys Gly Glu Tyr Asp Ser Lys Gly Thr Leu Leu 
                805                 810                 815     


Cys Asn Phe Thr Ser Val Glu Glu Arg Glu Ala Leu Trp Lys Glu Arg 
            820                 825                 830         


Glu Asp Arg Ser Gly Ser Tyr Arg Lys Leu Ala Thr Lys Lys Ile Lys 
        835                 840                 845             


Ser Asn Arg Leu Met Arg Asn Ala Ser Thr Asp Glu Val Asn Ser Ile 
    850                 855                 860                 


Leu Asp Lys Arg Leu Ser Asn Ser Arg Asn Glu Tyr Gln Lys Asn Glu 
865                 870                 875                 880 


Lys Ile Ile Arg Arg Tyr Lys Val Gln Asp Ala Leu Leu Phe Leu Leu 
                885                 890                 895     


Ala Lys Lys Ser Leu Thr Glu Met Ala Asp Phe Asp Gly Asn Lys Phe 
            900                 905                 910         


Lys Leu Lys Glu Ile Met Pro Asp Thr Glu Lys Gly Ile Leu Ser Glu 
        915                 920                 925             


Ile Met Pro Met Thr Phe Thr Phe Glu Lys Gly Gly Glu Arg Tyr Thr 
    930                 935                 940                 


Ile Thr Ser Glu Gly Met Lys Leu Lys Asn Tyr Gly Asp Phe Phe Val 
945                 950                 955                 960 


Leu Ala Asn Asp Lys Arg Leu Cys Lys Leu Leu Lys Ile Val Asp Ser 
                965                 970                 975     


Asp Thr Val Ser Lys Glu Asp Ile Met Glu Glu Phe Lys Arg Tyr Asp 
            980                 985                 990         


Gln Cys Arg Pro Glu Ile Ala Ser  Ile Val Phe Asn Leu  Glu Lys Trp 
        995                 1000                 1005             


Ala Phe  Asp Thr Tyr Pro Glu  Leu Ser Ala Lys Val  Asp Arg Glu 
    1010                 1015                 1020             


Glu Gln  Val Asp Phe Lys Phe  Ile Leu Asn Val Leu  Leu Asn Lys 
    1025                 1030                 1035             


Lys Asn  Ile Asn Asn Glu Gln  Ser Tyr Ile Leu Arg  Lys Ile Arg 
    1040                 1045                 1050             


Asn Ala  Phe Asp His Asn Asn  Tyr Pro Asp Lys Gly  Leu Val Glu 
    1055                 1060                 1065             


Ile Lys  Ala Leu Pro Glu Ile  Ala Met Ser Ile Lys  Lys Thr Phe 
    1070                 1075                 1080             


Gly Glu  Tyr Ala Ile Met Lys  
    1085                 1090 


<210>  1663
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1663

Met Glu Thr Lys Gln Gln Val Gly Lys Gly Ile Ser Tyr Asp His Arg 
1               5                   10                  15      


Arg Pro Asp Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asp Gly Val Ile Gln Glu Phe Ala Met Arg Leu Asn Arg 
        35                  40                  45              


Glu Tyr Asp Pro Glu Asn Lys Asn Gln Ser Leu Phe Ser Tyr Phe Asn 
    50                  55                  60                  


Ile Asn Ala Ser Phe Thr Asp Trp Glu Arg Gly Val Asn Ile Leu Lys 
65                  70                  75                  80  


Glu Tyr Trp Pro Met Met Glu Phe Ile Asp Arg Pro Ala Thr Asp Lys 
                85                  90                  95      


Gln Phe Glu Ala Glu Lys Pro Glu Asn Arg Glu Ala Ala Lys Arg Lys 
            100                 105                 110         


Tyr Phe Leu Ala Thr Leu Gly Ala Leu Leu Thr Ser Ile Lys Asp Leu 
        115                 120                 125             


Arg His Tyr Tyr Thr His Tyr Tyr His Pro Pro Val His Leu Asn Asp 
    130                 135                 140                 


Asp Leu Phe Leu Phe Leu Asp His Ala Leu Leu Tyr Thr Ala Phe Asp 
145                 150                 155                 160 


Val Lys Lys Thr Lys Met Lys Asp Asp Lys Thr Arg Gln Leu Leu Asn 
                165                 170                 175     


Gln Asn Leu Ser Leu Glu Leu Glu Lys Leu Lys Lys Leu Lys Val Glu 
            180                 185                 190         


Glu Leu Lys Lys Lys Lys Glu Lys Gly Ile Lys Val Asn Leu Gln Asp 
        195                 200                 205             


Glu Lys Gly Ile Leu Asn Ala Ile Tyr Asn Asp Ala Phe Ala His Ile 
    210                 215                 220                 


Ile Thr Lys Glu Lys Asp Ser Asp Lys Asp Lys Leu Glu Thr Arg Tyr 
225                 230                 235                 240 


Lys Ser Ile Leu Pro Gln Asp Glu Ala Ala Glu Thr Gly Ile Asn Ile 
                245                 250                 255     


Ser Ile Ser Gly Leu Ile Phe Leu Leu Ser Leu Phe Leu Ser Arg Lys 
            260                 265                 270         


Glu Ile Glu Gln Leu Lys Ser Asn Ile Glu Gly Tyr Lys Gly Lys Val 
        275                 280                 285             


Leu Asn Ile Glu Thr Glu Val Asp Arg Lys His Asn Ser Leu Lys Tyr 
    290                 295                 300                 


Met Ala Thr His Trp Val Phe Ser Ile Leu Ala Phe Lys Gly Leu Lys 
305                 310                 315                 320 


Gln Arg Leu Thr Asn Ser Phe Glu Lys Glu Ser Leu Leu Ile Gln Met 
                325                 330                 335     


Met Asp Glu Leu Asn Lys Val Pro Asp Glu Leu Tyr Gln Thr Leu Ser 
            340                 345                 350         


Glu Thr Ala Lys Lys Glu Phe Leu Glu Asp Ile Asn Glu Tyr Val Ser 
        355                 360                 365             


Glu Gly Asp Asp Asn Glu Lys Ala Thr Tyr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Ser Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gln Phe Pro Thr Leu Lys Phe Gln Ile Phe Val Gly 
                405                 410                 415     


Gln Tyr Leu His Asp Asn Arg Pro Lys Thr Leu Ala Ser Asn Gly Met 
            420                 425                 430         


Thr Ala Gln Arg Met Ile Lys Glu Lys Ile Asn Leu Phe Gly Asn Leu 
        435                 440                 445             


Ser Glu Val Thr Lys His Lys Ser Asp Phe Phe Glu Lys Glu Ser Ala 
    450                 455                 460                 


Ala Gln Gly Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Trp Ala Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Val Tyr Ile Asp Met Ile Gly Lys Glu Gly Lys Ala 
                485                 490                 495     


Lys Glu Ile Gln Val Gln Ile Asn Lys Tyr Arg Lys Gln Leu Asn Pro 
            500                 505                 510         


Ala Pro Gln Arg Asp Lys Arg Ile Ser Lys Lys Glu Ile Ile Glu Gln 
        515                 520                 525             


Leu Tyr Lys Glu Lys Val Val Tyr Gly Asp Pro Thr Leu Met Leu Ser 
    530                 535                 540                 


Ala Asn Glu Leu Met Ala Leu Leu Tyr Glu Leu Ile Val Asn Gly Lys 
545                 550                 555                 560 


Ser Gly Ala Glu Leu Glu Asn Lys Ile Val Glu Gln Ile Ile Ala Arg 
                565                 570                 575     


Tyr Glu Gln Ile Glu Ala Tyr Asp Pro Thr Thr Gln Gln Leu Pro Thr 
            580                 585                 590         


Asn Gln Met Pro His Lys Leu Gln Lys Ser Arg Lys Asp Ser Lys Val 
        595                 600                 605             


Thr Asp Thr Asp Lys Leu Leu Lys Thr Ile Asp Lys Glu Ile Asp Glu 
    610                 615                 620                 


Gly Asn Lys Lys Leu Glu Leu Ile Ala Cys His Arg Lys Glu Trp Glu 
625                 630                 635                 640 


Glu Ala Glu Gln Arg Lys Lys Ser Gly Lys Arg Asn Asn Pro Gly Thr 
                645                 650                 655     


Lys Ser Arg Lys His Leu Phe Tyr Ala Ser Glu Met Gly Glu Glu Ala 
            660                 665                 670         


Thr Trp Ile Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Pro Ala Arg 
        675                 680                 685             


Ala Glu Trp Lys Gly Thr His His Ser Glu Leu Gln Arg Leu Leu Ala 
    690                 695                 700                 


Phe Tyr Ser Thr Gln Arg Leu Glu Ala Trp Gln Leu Val Glu Ser Val 
705                 710                 715                 720 


Trp Thr Ala Asn Thr His Ser Phe Trp Glu Glu Asn Phe Lys Glu Ala 
                725                 730                 735     


Phe Tyr Lys Pro Glu Phe Glu Asn Phe Tyr Gly Ala Tyr Ile Glu Ile 
            740                 745                 750         


Arg Thr Lys Ile Leu Thr Thr Cys Arg Ser Ile Leu Glu Asn Asn Pro 
        755                 760                 765             


Glu Ala Thr Met Asn Asn Asp Thr Glu Lys Glu Trp Asp Lys Val Phe 
    770                 775                 780                 


Thr Leu Phe Asp Lys Arg Leu Tyr Arg Thr Ser Thr Thr Asp Glu Gln 
785                 790                 795                 800 


Lys Lys Gln Leu Leu Thr Lys Pro Phe Ala Phe Pro Arg Gly Leu Phe 
                805                 810                 815     


Asp Asp Lys Pro Thr Phe Leu Pro Gly Ser Lys Pro Asn Glu Asn Pro 
            820                 825                 830         


Glu Arg Phe Ala Ala Trp Tyr Ser Tyr Gly Tyr Thr Tyr Ser Gly Lys 
        835                 840                 845             


Phe Gln Ser Phe Tyr Asp Met Pro Arg Asn Tyr Ser Asp Trp Tyr Lys 
    850                 855                 860                 


Lys Leu Lys Glu Asp Gly Lys Leu Pro Arg Leu Asp Lys Lys Thr Glu 
865                 870                 875                 880 


Gln Glu Lys Ile Leu Arg Phe Arg Met Asp Cys Asp Leu Asn Ile Lys 
                885                 890                 895     


His Ile Arg Phe Gln Asp Ile Tyr Val Lys Leu Met Val Asp Ser Leu 
            900                 905                 910         


Tyr Lys Ala Val Phe Gly Gln Gln Pro Glu Phe Asp Leu Ser His Leu 
        915                 920                 925             


Tyr Asp Thr Arg Ser Glu Arg Tyr Glu Asn Asn Thr Ile Ala Gln Arg 
    930                 935                 940                 


Gln Lys Ser Arg Gln Glu Gly Asp Asn Ser Asp Asn Ala Ile Asn Glu 
945                 950                 955                 960 


Asn Tyr Val Trp Asn Lys Thr Phe Ala Ile Ser Leu Tyr Asn Gly Arg 
                965                 970                 975     


Ile Thr Glu Ser Gln Val Lys Leu Lys Asp Val Gly Lys Phe Arg Arg 
            980                 985                 990         


Phe Ala Thr Asp Pro Arg Val Gln  Thr Leu Ile Ser Tyr  Asp Asp Thr 
        995                 1000                 1005             


Arg Thr  Trp Thr Lys Leu Glu  Ile Glu Asn Glu Leu  Asp Asn Lys 
    1010                 1015                 1020             


Ala Asp  Ala Tyr Glu Pro Ile  Arg Arg Thr Gln Ser  Leu Lys Ala 
    1025                 1030                 1035             


Ile Gln  Gln Leu Glu Lys Asn  Ile Leu Lys Lys Asn  Gly Phe Asn 
    1040                 1045                 1050             


Gly Lys  Gln His Pro Glu Glu  Leu Lys His Asn Gly  Asn Pro Asn 
    1055                 1060                 1065             


Phe Arg  Lys Tyr Ile Ala Asn  Gly Leu Leu Lys His  Arg Thr Asp 
    1070                 1075                 1080             


Ile Arg  Gln Glu Glu Leu Ala  Leu Ile Ser Asp Thr  Glu Phe Gln 
    1085                 1090                 1095             


Glu Ile  Gly Leu Glu Arg Ile  Arg Gln Thr Asn Pro  Leu Ile Gln 
    1100                 1105                 1110             


Lys Ala  Tyr Leu Leu Ile Leu  Leu Arg Asn Lys Phe  Gly His Asn 
    1115                 1120                 1125             


Gln Leu  Pro Asp Gln Glu His  Phe Arg Leu Met Arg  Ser Ile Tyr 
    1130                 1135                 1140             


Pro Tyr  Asn Gln Gln Glu Ser  Tyr Ser Ala Tyr Phe  Asn His Val 
    1145                 1150                 1155             


Ile Thr  Gln Ile Ile Glu Glu  Leu Asn Thr 
    1160                 1165             


<210>  1664
<211>  1119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1664

Met Thr Glu Gln Asn Glu Lys Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Thr His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Ser Met Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Tyr Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Gly Thr Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Thr Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Pro Leu Ala Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Ser Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Phe Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Glu Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Gly Glu Ile Asn Thr Arg Asp 
    530                 535                 540                 


Glu Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Lys His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Ser Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Tyr Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Ser Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Leu Ala Lys Leu Lys Lys Glu Ile Leu Glu Ala 
        835                 840                 845             


Lys Glu His Pro Tyr Leu Asp Phe Lys Ser Trp Gln Lys Phe Glu Arg 
    850                 855                 860                 


Glu Leu Arg Leu Val Lys Asn Gln Asp Ile Ile Thr Trp Met Ile Cys 
865                 870                 875                 880 


Arg Asp Leu Met Glu Glu Asn Lys Val Glu Gly Leu Asp Thr Gly Thr 
                885                 890                 895     


Leu Tyr Leu Lys Asp Ile Arg Thr Asp Val Gln Glu Gln Gly Ser Leu 
            900                 905                 910         


Asn Val Leu Asn Arg Val Lys Pro Met Arg Leu Pro Val Val Val Tyr 
        915                 920                 925             


Arg Ala Asp Ser Arg Gly His Val His Lys Glu Gln Ala Pro Leu Ala 
    930                 935                 940                 


Thr Val Tyr Ile Glu Glu Arg Asp Thr Lys Leu Leu Lys Gln Gly Asn 
945                 950                 955                 960 


Phe Lys Ser Phe Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe 
                965                 970                 975     


Val Asp Thr Gly Ala Leu Ala Met Glu Gln Tyr Pro Ile Ser Lys Leu 
            980                 985                 990         


Arg Val Glu Tyr Glu Leu Ala Lys  Tyr Gln Thr Ala Arg  Val Cys Ala 
        995                 1000                 1005             


Phe Glu  Gln Thr Leu Glu Leu  Glu Glu Ser Leu Leu  Thr Arg Cys 
    1010                 1015                 1020             


Pro His  Leu Pro Asp Lys Asn  Phe Arg Lys Met Leu  Glu Ser Trp 
    1025                 1030                 1035             


Ser Asp  Pro Leu Leu Asp Lys  Trp Pro Asp Leu His  Arg Lys Val 
    1040                 1045                 1050             


Arg Leu  Leu Ile Ala Val Arg  Asn Ala Phe Ser His  Asn Gln Tyr 
    1055                 1060                 1065             


Pro Met  Tyr Asp Glu Ala Val  Phe Ser Ser Ile Arg  Lys Tyr Asp 
    1070                 1075                 1080             


Pro Ser  Phe Pro Asp Ala Ile  Glu Glu Arg Met Gly  Leu Asn Ile 
    1085                 1090                 1095             


Ala His  Arg Leu Ser Glu Glu  Val Lys Gln Ala Lys  Glu Thr Val 
    1100                 1105                 1110             


Glu Arg  Ile Ile Gln Ala 
    1115                 


<210>  1665
<211>  1175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1665

Met Thr Glu Gln Asn Glu Lys Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Phe Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Ala His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Cys Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Glu Lys Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Ala Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Phe Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Asp Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Gly Glu Ile Asp Thr Leu Asp 
    530                 535                 540                 


Arg Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Met Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Gly Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Tyr Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Trp Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Asp Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Asp Leu Glu Ala Trp Ser His Ser Ala Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Ala Gly Ile Glu Tyr Ala Ser Pro Gly Asn 
    850                 855                 860                 


Lys Lys Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Glu Thr 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Lys Ala Asp Lys Ile Asn Ile Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Ala Gln Glu His Pro Tyr Leu Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asp Ile Arg Thr 
945                 950                 955                 960 


Glu Val Gln Glu Gln Gly Ser Leu Asn Val Leu Asn Arg Val Lys Pro 
                965                 970                 975     


Met Arg Leu Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val 
            980                 985                 990         


His Lys Glu Gln Ala Pro Leu Ala  Thr Val Tyr Ile Glu  Glu Arg Asp 
        995                 1000                 1005             


Thr Lys  Leu Leu Lys Gln Gly  Asn Phe Lys Ser Phe  Val Lys Asp 
    1010                 1015                 1020             


Arg Arg  Leu Asn Gly Leu Phe  Ser Phe Val Asp Thr  Gly Gly Leu 
    1025                 1030                 1035             


Ala Met  Glu Gln Tyr Pro Ile  Ser Lys Leu Arg Val  Glu Tyr Glu 
    1040                 1045                 1050             


Leu Ala  Lys Tyr Gln Thr Ala  Arg Val Cys Val Phe  Glu Gln Thr 
    1055                 1060                 1065             


Leu Glu  Leu Glu Glu Ser Leu  Leu Thr Arg Cys Pro  His Leu Pro 
    1070                 1075                 1080             


Asp Lys  Asn Phe Arg Lys Met  Leu Glu Ser Trp Ser  Asp Pro Leu 
    1085                 1090                 1095             


Leu Asp  Lys Trp Pro Asp Leu  His Gly Asn Val Arg  Leu Leu Ile 
    1100                 1105                 1110             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1115                 1120                 1125             


Glu Ala  Val Phe Ser Ser Ile  Arg Lys Tyr Asp Pro  Ser Ser Leu 
    1130                 1135                 1140             


Asp Ala  Ile Glu Glu Arg Met  Gly Leu Asn Ile Ala  His Arg Leu 
    1145                 1150                 1155             


Ser Glu  Glu Val Lys Gln Ala  Lys Glu Met Val Glu  Arg Ile Ile 
    1160                 1165                 1170             


Gln Val  
    1175 


<210>  1666
<211>  1267
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1666

Met Glu Lys Gln Arg Arg Arg Gln Thr Arg Asp Phe Ser Ile Arg Leu 
1               5                   10                  15      


Thr Gly Lys Tyr Val Phe Gly Ala Tyr Phe Asn Met Ala Gln Ala Asn 
            20                  25                  30          


Phe Val Lys Thr Ile Val His Ile Leu Pro Ile Val Gly Ile Gly Gly 
        35                  40                  45              


Asn Tyr Gln Glu Asn Gln Val Gly Lys Met Leu His Ala Leu Trp Leu 
    50                  55                  60                  


Ile Thr Ala Gly Lys Ala Gln Glu Leu Asp Ser Gln Glu Lys Glu Trp 
65                  70                  75                  80  


Glu Lys Lys Leu Arg Leu Asn Pro Glu Lys Gln Leu Gln Leu Gln Lys 
                85                  90                  95      


Leu Leu Phe Lys His Phe Pro Val Leu Asn Pro Met Met Ala Asp Val 
            100                 105                 110         


Ala Asn Tyr Arg Ala Tyr Leu Lys Asp Gln Lys Ser Lys Val Lys Thr 
        115                 120                 125             


Asp Lys Asp Thr Phe Glu Gln Met Arg Gly Val Ser Val Ala Asp Cys 
    130                 135                 140                 


Leu Glu Met Phe Tyr Leu Met Ala Val Thr Leu Asn Asp Cys Arg Asn 
145                 150                 155                 160 


Phe Tyr Thr His Lys Asn Pro Tyr Asn Ser Glu Glu Glu Leu Lys Lys 
                165                 170                 175     


Gln Tyr Lys His Gln Glu Arg Ile Ala Gln Lys Leu Asp Lys Val Val 
            180                 185                 190         


Val Ala Ser Arg Arg Val Tyr Lys Glu Arg Glu Gly Leu Leu Pro Thr 
        195                 200                 205             


Glu Met Glu Phe Leu Thr Gly Ile Asp His Met His Pro Val Val Val 
    210                 215                 220                 


Lys Asp Glu Asn Gly Gln Val Val Lys Asp Lys Asn Glu Lys Val Ile 
225                 230                 235                 240 


Lys Gln Phe Lys Glu Tyr Asp Asp Phe Tyr Phe Arg Ile Thr Gly Glu 
                245                 250                 255     


Arg Thr Ile Asn Glu Asn Ser Lys Glu Lys Ala Val Ala Leu Ser Asp 
            260                 265                 270         


Phe Gly Leu Leu Tyr Phe Cys Val Gln Phe Leu Ser Lys Pro Tyr Ala 
        275                 280                 285             


Lys Leu Phe Met Asp Glu Ala Arg Leu Phe Glu Phe Ser Pro Phe Thr 
    290                 295                 300                 


Asp Glu Glu Asn Ile Ile Leu Gln Glu Met Leu Cys Ile Tyr Arg Ile 
305                 310                 315                 320 


Arg Met Pro Lys Pro His Arg Ile Asp Ser Lys Asp Ser Lys Thr Ala 
                325                 330                 335     


Leu Ala Met Asp Ile Phe Gln Glu Leu Arg Arg Cys Pro Met Lys Leu 
            340                 345                 350         


Tyr Asn Leu Phe Asp Lys Asn Ala Gln Gly Phe Phe His Asp Val Val 
        355                 360                 365             


Arg Arg Gln Asn Ser His Thr Asp Asp Val Ser Lys Arg Leu Arg His 
    370                 375                 380                 


Gly Asp Arg Phe Pro His Leu Ala Leu Arg Leu Ile Asp Glu Glu Gly 
385                 390                 395                 400 


Ile Phe Lys Arg Ile Arg Phe Gln Leu Arg Leu Gly Ser Phe Arg Phe 
                405                 410                 415     


Lys Phe Tyr Asp Lys Lys Cys Ile Asp Gly Arg Glu Arg Val Arg Arg 
            420                 425                 430         


Ile Gln Lys Glu Ile Asn Gly Tyr Gly Arg Leu Gln Glu Val Asn Asp 
        435                 440                 445             


Lys Arg Phe Glu Lys Trp Gly Asp Met Ile Gln Gln His Glu Glu Lys 
    450                 455                 460                 


Ser Val Lys Leu Glu His Glu Asp Leu Tyr Leu Asp Leu Asp Gln Phe 
465                 470                 475                 480 


Pro Gln Asp Thr Ala Glu Ser Ser Pro Tyr Ile Thr Asp Arg Arg Pro 
                485                 490                 495     


Ala Tyr Asn Ile His Ala Asn Arg Ile Gly Leu Phe Trp Glu Asp Ser 
            500                 505                 510         


Gln Asn Pro Asn Asp Phe Val Tyr Phe Asp Val Asn Lys Met Tyr Met 
        515                 520                 525             


Pro Glu Leu Lys Val Ser Asp Gly Lys Ala Pro Ile Lys Met Pro Ala 
    530                 535                 540                 


Pro Arg Ala Phe Leu Ser Val His Glu Leu Pro Ala Met Leu Phe Tyr 
545                 550                 555                 560 


Glu Tyr Leu Arg Thr Gln Gln Lys Glu Lys Leu Pro Ser Ala Glu Gln 
                565                 570                 575     


Ile Ile Ile Asp Cys Glu Ala Tyr Tyr Arg Arg Phe Phe Asn Asp Val 
            580                 585                 590         


Glu Thr Gly Arg Leu Lys Pro Phe Pro Lys Ala Lys Asp Phe Arg Gln 
        595                 600                 605             


His Leu Ala Glu Glu Tyr Pro Asn Leu Arg Phe Ser Asp Ile Pro Gln 
    610                 615                 620                 


Lys Ile Leu Leu Tyr Leu Cys Ser Gln Gly Trp Arg Tyr Glu Asn Arg 
625                 630                 635                 640 


Pro Glu Thr Ser Gln Glu Arg Leu Leu Arg Lys Thr Ile Gln His Leu 
                645                 650                 655     


Glu Glu Arg Glu Val Arg Ile Gln Arg Arg Leu Glu Arg Tyr Lys Glu 
            660                 665                 670         


Asp Arg Glu Gln Ile Gly Ser Asp Asp Asn Lys Phe Glu Lys Lys Gly 
        675                 680                 685             


Phe Val Asp Val Arg His Gly Ala Leu Ala Arg Tyr Leu Ala Lys Ser 
    690                 695                 700                 


Leu Met Glu Trp Gln Pro Ser Lys Asp Gly Lys Gly His Asp Lys Leu 
705                 710                 715                 720 


Thr Gly Ile Asn Tyr Asn Val Leu Thr Ser Tyr Leu Ala Thr Leu Gly 
                725                 730                 735     


Ser Phe Ala Ser Gln Thr Asp Glu Thr Glu Val Ser Ser Leu Trp Gln 
            740                 745                 750         


Val Met Lys Asp Ala Asn Leu Ile Asp Gly Asn Asn Pro His Pro Phe 
        755                 760                 765             


Ile Gly Lys Val Leu Gln Lys Cys Asn Arg Asn Ile Glu Glu Leu Tyr 
    770                 775                 780                 


Leu His Tyr Leu Glu Glu Glu Ile Glu His Ile Arg Ser Cys His Lys 
785                 790                 795                 800 


Asn Leu Lys Glu Lys Leu Phe Gln Gly Leu Ser Cys Leu Pro Phe Val 
                805                 810                 815     


His His Glu Arg Leu Arg Tyr His Gly Leu Trp Asn Glu Glu Met Arg 
            820                 825                 830         


Ala Leu Ala Gly Arg Tyr Glu Ser Val Gln Leu Pro Asp Gly Leu Phe 
        835                 840                 845             


Thr Arg Tyr Ile Leu Glu Ile Leu Gln Lys His Tyr Ala Asp Asn Ala 
    850                 855                 860                 


Asp Leu Gln Lys Ala Leu Asn Leu Lys Val Pro Glu Lys Ser Asn Pro 
865                 870                 875                 880 


Asn Arg Asn Ile Thr Phe Leu Ile Ser Arg Phe Tyr Glu Leu Glu Leu 
                885                 890                 895     


His Asp Ala Pro Gln Pro Tyr Tyr Ile Ser Asp Lys Pro Leu Ala Met 
            900                 905                 910         


Asp Asn Asp Gly Arg Gln Glu Glu Tyr Ser Phe Lys Arg Ala Tyr Glu 
        915                 920                 925             


Leu Phe Ser Ile Leu Asp Asn Lys Lys Gln Leu Thr Ser Asp Glu Ile 
    930                 935                 940                 


Gln Lys Arg Leu Thr Ala Lys Leu Leu Asp Asn Glu Gly Arg Pro Ile 
945                 950                 955                 960 


Pro Glu Leu Gly Lys Arg Gly Lys Ala Ala Met Asp Thr Gln Glu Asn 
                965                 970                 975     


Ile Ile Trp Gln Arg Lys Ile Ala Lys Glu Ile Glu Ser Tyr Ile Asn 
            980                 985                 990         


Ser Leu Ser Asp Lys Asp Leu Lys  Ile Pro Leu Asn Cys  Lys Lys Glu 
        995                 1000                 1005             


Lys Lys  Glu Glu Glu Arg Asn  Lys Arg Lys Glu Ala  Leu Ala Asn 
    1010                 1015                 1020             


Arg Leu  Lys Ser Gln Ile Lys  Asp Ile Lys Asn Thr  Glu Arg Gln 
    1025                 1030                 1035             


Ile Leu  Arg Tyr Arg Thr Gln  Asp Met Val Leu Phe  Leu Met Ala 
    1040                 1045                 1050             


Lys Asp  Ala Phe Val Arg Ile  Met Asp Glu Gln Gly  Asn Asp Val 
    1055                 1060                 1065             


Asn Trp  Asp Asn Leu Cys Leu  Ala Lys Val Cys Asp  Asp Gly Phe 
    1070                 1075                 1080             


Leu Arg  Gln Ala Phe Thr Phe  Gln Ile Pro Val Leu  Ile Gly Asp 
    1085                 1090                 1095             


Glu Thr  Ile Tyr Ile Glu Gln  Glu Asn Met Ser Met  Val Asn Tyr 
    1100                 1105                 1110             


Gly Glu  Leu Arg Gln Ile Leu  Ala Asp Asp Arg Leu  Glu Ser Leu 
    1115                 1120                 1125             


Leu Lys  Asn Ile Ala Glu Asn  Ile Glu Pro Asn Thr  Lys Gly Lys 
    1130                 1135                 1140             


Lys Ile  Ile Arg Tyr Thr Asp  Leu Met Ser Glu Leu  Ala Ala Tyr 
    1145                 1150                 1155             


Asp Arg  Ile Arg Ser Thr Val  Phe Lys Leu Ile Gln  Gln Ile Glu 
    1160                 1165                 1170             


Gln Phe  Val Leu Asp Lys Phe  Asp Tyr Leu Ala Asp  Pro Thr Lys 
    1175                 1180                 1185             


Glu Asp  Phe Trp Glu Asn Lys  Ser Leu Pro Lys Arg  Asn Ser Phe 
    1190                 1195                 1200             


Lys Ala  Met Ile Glu Leu Ile  Asp Arg Leu Asn Asp  Lys Pro Leu 
    1205                 1210                 1215             


Thr Pro  Ser Glu Arg Ser Leu  Ile Ile Ala Ile Arg  Asn Ala Phe 
    1220                 1225                 1230             


Gly His  Asn Thr Tyr Lys Val  Asp Leu Ser Gln Ile  Arg Asp Val 
    1235                 1240                 1245             


Arg His  Leu Pro Glu Val Ala  Arg Gly Ile Leu Lys  His Leu Glu 
    1250                 1255                 1260             


Thr Leu  Val Gly 
    1265         


<210>  1667
<211>  1085
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1667

Met Lys Lys Glu Leu Asn Arg Glu Asp Val Phe Thr Gly Gly Lys Thr 
1               5                   10                  15      


Pro Glu Leu Thr Ile Tyr Tyr Asn Ile Ala Tyr Phe Arg Met Ala Gly 
            20                  25                  30          


Leu Ile Asn Ala Leu Cys Gly Asn Lys Leu Glu Arg Asp Lys Asp Ala 
        35                  40                  45              


Leu Glu Gln Phe Met Lys Ala Phe Ile Asn Gly Lys Gln Lys Leu Thr 
    50                  55                  60                  


Asp Met Gln Phe Val Lys Leu Cys Asp Tyr Leu Trp Lys Gly Tyr Lys 
65                  70                  75                  80  


Tyr Asp Lys Asn Arg Ser Glu Tyr Ser Leu Thr Glu Asn Asp Lys Thr 
                85                  90                  95      


Met Val Leu Lys Met Val Ala Lys Leu Gln Asp Ile Arg Asn Phe Gln 
            100                 105                 110         


Ser His Ile Trp His Asp Asn Lys Val Leu Val Phe Asp Ala Asp Leu 
        115                 120                 125             


Val Gln Phe Ile Lys Asn Lys His Leu Glu Ala Ile Asp Ala Gln Arg 
    130                 135                 140                 


Gln Arg Phe Ser Lys Glu Thr Glu Val Tyr Glu Lys Glu Asn Arg Glu 
145                 150                 155                 160 


Leu Lys Lys Lys Lys Asn Lys Glu Leu Leu Phe Asp Ile His Asp Gly 
                165                 170                 175     


Leu Gly Tyr Ile Thr Gly Glu Gly Arg Asn Phe Phe Leu Ser Phe Phe 
            180                 185                 190         


Leu Thr Arg Gly Glu Met Thr Arg Phe Leu Lys Gln Arg Lys Gly Cys 
        195                 200                 205             


Lys Arg Asp Asp Thr Pro Glu Tyr Lys Ile Lys His Leu Val Tyr Arg 
    210                 215                 220                 


His Phe Thr His Arg Asp Gly Ala Thr Arg Thr His Tyr Gly Tyr Glu 
225                 230                 235                 240 


Asp Asn Met Leu Asp Gln Leu Pro Asp Lys Gln Glu Phe Leu Thr Thr 
                245                 250                 255     


Arg His Thr Tyr Arg Leu Ile Asn Tyr Leu Asn Asp Ile Pro Glu Glu 
            260                 265                 270         


Val Thr Asn Pro Glu Leu Phe Pro Leu Phe Asn Thr Ile Ser Asn Gly 
        275                 280                 285             


Ile Leu Ile Lys Glu Ser Val Gly Thr Tyr Ile Ala Phe Ile Asn Lys 
    290                 295                 300                 


Met Pro Leu Leu Ser Asp Phe Glu Phe Ser Glu Val Trp Gly Lys Asp 
305                 310                 315                 320 


Gly Lys Pro Tyr Thr Asn Leu Val Glu Phe Tyr His Lys Thr Gln Pro 
                325                 330                 335     


Gly Phe Lys Phe Arg Thr Asp Leu Asn Ser Phe His Lys Ile Ile Leu 
            340                 345                 350         


Asn Leu Ile Arg Asp Glu Asn Tyr Thr Gly Phe Phe Thr Thr Gln Leu 
        355                 360                 365             


Asn Leu Phe Met Ala His Arg Glu Glu Leu Ile Leu Val Ile Ser Lys 
    370                 375                 380                 


Pro Leu Ile Thr Pro Asn Asp Leu Leu Leu Ile Glu Glu His Tyr Arg 
385                 390                 395                 400 


Tyr Lys Leu Lys Ala Asn Asp Phe Val Arg Glu Lys Leu Gly Glu Trp 
                405                 410                 415     


Lys Glu Lys Ile Glu Lys Gly Lys Trp Glu Lys Ala Asn Glu Gln Lys 
            420                 425                 430         


Asp Lys Leu Ile Asn Leu Leu Gly Gly Val Ile Glu Ile Thr Phe Tyr 
        435                 440                 445             


Asp Phe Tyr Trp Gln Lys Asp Glu Lys Pro Arg Asn Glu Asn Arg Phe 
    450                 455                 460                 


Met Glu Phe Ala Ile Arg Phe Met Ala Asp Phe Asn Leu Leu Pro Asp 
465                 470                 475                 480 


Cys Glu Trp Glu Val Glu Pro Leu Gln Ile Glu Asn Asp Leu Ile Ala 
                485                 490                 495     


Asn Arg Thr Ala Thr Pro Asp Leu Lys Lys Ser Gly Ser Gln Phe Met 
            500                 505                 510         


Asn Gln Leu Thr Asp Asn Tyr Arg Leu Lys Phe Asn Asp Gly Gln Ile 
        515                 520                 525             


Ala Phe Arg Tyr Gln Asn Gln Val Phe Ile Met Gly His Lys Ala Val 
    530                 535                 540                 


Lys Asn Leu Leu Ile Ala Cys Phe Asp Gly Lys Glu Lys Met Leu Asn 
545                 550                 555                 560 


Gly Phe Met Pro Ala Leu Leu Ala Asp Leu Lys Lys Ile Thr Asn Glu 
                565                 570                 575     


His Ile Leu Lys Asn His Gln Ala Leu Asn Thr Leu Ser Leu Leu Asn 
            580                 585                 590         


Asn Asp Ser Ile Pro Ser Tyr Ile Ser Arg Gln Trp Gly Glu Ala Glu 
        595                 600                 605             


Pro Ile Thr Asp Met Lys Lys Lys Ala Ile Ala Arg Met Asp Tyr Ile 
    610                 615                 620                 


Thr Gln Gln Phe Glu Ala Leu Ile Glu Asn His His Tyr Leu Asn Arg 
625                 630                 635                 640 


Ala Asp Lys Asn Arg Gln Ile Met Arg Cys Tyr Lys Phe Phe Glu Trp 
                645                 650                 655     


Gln Tyr Pro Gln Asn Ser Gln Phe Lys Phe Leu Arg Arg Asn Glu Tyr 
            660                 665                 670         


His Arg Met Ser Ile Tyr His Tyr Cys Leu Asp Lys Glu Gln His Lys 
        675                 680                 685             


Tyr Asp Lys Lys Gly His Asn Tyr Leu Tyr Asn Arg Leu Ile Lys Glu 
    690                 695                 700                 


Ser His Asn Glu Ser Gly Asn Ile Glu Gln His Leu Pro Tyr Gln Ile 
705                 710                 715                 720 


Arg Thr Met Leu Asn Asp Ala Lys Asp Phe Asn Asp Tyr Phe Leu Arg 
                725                 730                 735     


Ile Leu Asn Ala Thr His Lys Ile Leu Thr Asp Trp Lys Asn Gln Leu 
            740                 745                 750         


Lys Gln Gly Arg Glu Pro Asn Asn Tyr Tyr Leu Ser Arg Leu Gly Phe 
        755                 760                 765             


Thr Gly Gly Leu Thr Gln Lys Val Val His Thr Arg Leu Leu Pro Phe 
    770                 775                 780                 


Ser Ile His Pro Gly Ile Pro Val Ser Phe Phe Tyr Arg Thr Glu Met 
785                 790                 795                 800 


Asn Gln Asn Pro Ser Phe Asn Leu Ser Ala Lys Val Trp Asn Ser Glu 
                805                 810                 815     


Ser Pro Phe Arg Val Gly Leu Lys Glu Ser Asn Tyr Gln Tyr Ala Lys 
            820                 825                 830         


Tyr Leu Gly Leu Phe Asn Glu Ile Lys Thr Gln Arg Lys Ile Ile Gly 
        835                 840                 845             


Lys Met Asn Gln Leu Ile Ala Glu Asp Ala Leu Leu Trp Gln Ile Ala 
    850                 855                 860                 


Lys Lys Tyr Leu Asp Lys Cys His Pro Lys Phe Ser Glu Ile Ile Asn 
865                 870                 875                 880 


Gln Gln Val Asn Gly Lys Gln Pro Leu Asn Val Lys Ala Ile His Asp 
                885                 890                 895     


Thr Glu Leu Thr Ile Asp Phe Pro Val Asp Lys Asn Leu Tyr Gln Val 
            900                 905                 910         


Val Val Lys Met Lys Gln Leu Asp Asp Phe Met Phe Ile Asp Ser Lys 
        915                 920                 925             


Pro Val Leu Glu Lys Thr Ile Arg Tyr Met Ile Lys Asn Ser Leu Arg 
    930                 935                 940                 


Asp Lys Glu Tyr Gln Gln Arg Val Phe Ile Glu Thr Asn Pro Gly Val 
945                 950                 955                 960 


Phe Lys Ile Pro Tyr Asn Glu Val Val Glu Ala Met Arg Thr Ile Asn 
                965                 970                 975     


His Gln Ala Leu Thr Trp Ala Arg Leu Leu Leu Asp Trp Glu Ser Lys 
            980                 985                 990         


Thr Val Lys Thr Ile Pro Glu Ala  Asp Lys Lys Ala Lys  Leu Gln Glu 
        995                 1000                 1005             


Ala Tyr  Asn Lys Arg Gln Pro  Ala Phe Phe Asn Phe  Asn Asp Ile 
    1010                 1015                 1020             


Cys Arg  Tyr Ala Asp Asp Gly  Lys Gln Leu Lys Asp  Leu Arg Asn 
    1025                 1030                 1035             


Lys Thr  Phe His Thr Glu Val  Pro Glu Thr Trp Thr  Tyr Asp Glu 
    1040                 1045                 1050             


Met Arg  Glu Asn Lys Thr Ile  Lys Met Val Leu Gly  Ile Asn Glu 
    1055                 1060                 1065             


Thr Thr  Phe Leu Lys Lys Asp  Tyr Ala Ile Glu Asn  Ala Arg Thr 
    1070                 1075                 1080             


Ile Glu  
    1085 


<210>  1668
<211>  1025
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1668

Met Lys His Phe Pro Phe Leu Glu Ala Ala Ala Tyr Glu Met Thr Asn 
1               5                   10                  15      


Ser Lys Ser Pro Asn Asn Lys Glu Gln Arg Glu Lys Glu Gln Ser Glu 
            20                  25                  30          


Ala Leu Ser Leu Asn Asn Leu Lys Asn Val Leu Phe Ile Phe Leu Glu 
        35                  40                  45              


Lys Leu Gln Val Leu Arg Asn Tyr Tyr Ser His Tyr Lys Tyr Ser Glu 
    50                  55                  60                  


Glu Ser Pro Lys Pro Ile Phe Glu Thr Ser Leu Leu Lys Asn Met Tyr 
65                  70                  75                  80  


Lys Val Phe Asp Ala Asn Val Arg Leu Val Lys Arg Asp Tyr Met His 
                85                  90                  95      


His Glu Asn Ile Asp Met Gln Arg Asp Phe Thr His Leu Asn Arg Lys 
            100                 105                 110         


Lys Gln Val Gly Arg Thr Lys Asn Ile Ile Asp Ser Pro Asn Phe His 
        115                 120                 125             


Tyr His Phe Ala Asp Lys Glu Gly Asn Met Thr Ile Ala Gly Leu Leu 
    130                 135                 140                 


Phe Phe Val Ser Leu Phe Leu Asp Lys Lys Asp Ala Ile Trp Met Gln 
145                 150                 155                 160 


Lys Lys Leu Lys Gly Phe Lys Asp Gly Arg Asn Leu Arg Glu Gln Met 
                165                 170                 175     


Thr Asn Glu Val Phe Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys 
            180                 185                 190         


Leu Glu Asn Val Gln Thr Lys Asp Trp Met Gln Leu Asp Met Leu Asn 
        195                 200                 205             


Glu Leu Val Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Arg Glu Lys 
    210                 215                 220                 


Asp Arg Glu Ser Phe Lys Val Pro Phe Asp Ile Phe Ser Asp Asp Tyr 
225                 230                 235                 240 


Asp Ala Glu Glu Glu Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp 
                245                 250                 255     


Arg Phe Pro Tyr Phe Val Leu Arg Phe Phe Asp Leu Asn Glu Ile Phe 
            260                 265                 270         


Glu Gln Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile 
        275                 280                 285             


Tyr Asn Lys Leu Ile Gly Asp Glu Asp Glu Val Arg His Leu Thr His 
    290                 295                 300                 


His Leu Tyr Gly Phe Ala Arg Ile Gln Asp Phe Ala Pro Gln Asn Gln 
305                 310                 315                 320 


Pro Glu Glu Trp Arg Lys Leu Val Lys Asp Leu Asp His Phe Glu Thr 
                325                 330                 335     


Ser Gln Lys Pro Tyr Ile Ser Lys Thr Ala Pro His Tyr His Leu Glu 
            340                 345                 350         


Asn Glu Lys Ile Gly Ile Lys Phe Cys Ser Thr His Asn Asn Leu Phe 
        355                 360                 365             


Pro Ser Leu Lys Arg Glu Lys Thr Cys Asn Gly Arg Ser Lys Phe Asn 
    370                 375                 380                 


Leu Gly Thr Gln Phe Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu 
385                 390                 395                 400 


Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Thr Lys Asp His Pro Lys 
                405                 410                 415     


Gly Glu Gly Ile Asn Lys Ile Glu Lys Ile Ile Arg Thr Glu Ile Ser 
            420                 425                 430         


Asn Ile Tyr Ala Ile Tyr Asp Ala Phe Ala Asn Gly Glu Ile Asn Ser 
        435                 440                 445             


Ile Ala Asp Leu Thr Cys Arg Leu Gln Lys Thr Asn Ile Leu Gln Gly 
    450                 455                 460                 


His Leu Pro Lys Gln Met Ile Ser Ile Leu Gly Gly Arg Gln Lys Asp 
465                 470                 475                 480 


Met Glu Lys Glu Ala Glu Arg Lys Ile Gly Glu Met Ile Asp Asp Thr 
                485                 490                 495     


Gln Arg Arg Leu Asp Leu Leu Cys Lys Gln Thr Asn Gln Lys Ile Arg 
            500                 505                 510         


Ile Gly Lys Arg Asn Ala Gly Leu Leu Lys Ser Gly Lys Ile Ala Asp 
        515                 520                 525             


Trp Leu Val Ser Asp Met Met Arg Phe Gln Pro Val Gln Lys Asp Thr 
    530                 535                 540                 


Asn Asn Ala Pro Ile Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg 
545                 550                 555                 560 


Met Leu Gln His Ala Leu Ala Leu Phe Gly Ser Glu Ser Ser Arg Leu 
                565                 570                 575     


Lys Ala Tyr Phe Arg Gln Met Asn Leu Val Gly Asn Ala Asn Pro His 
            580                 585                 590         


Pro Phe Leu Ala Glu Thr Gln Trp Glu His Gln Thr Asn Ile Leu Ser 
        595                 600                 605             


Phe Tyr Arg Asn Tyr Leu Glu Ala Arg Lys Lys Tyr Leu Lys Gly Leu 
    610                 615                 620                 


Lys Pro Gln Asn Trp Lys Gln Tyr Gln His Phe Leu Ile Leu Lys Val 
625                 630                 635                 640 


Gln Lys Thr Asn Arg Asn Thr Leu Val Thr Gly Trp Lys Asn Ser Phe 
                645                 650                 655     


Asn Leu Pro Arg Gly Ile Phe Thr Gln Pro Ile Arg Glu Trp Phe Glu 
            660                 665                 670         


Lys His Asn Asn Ser Lys Arg Ile Tyr Asp Gln Ile Leu Ser Phe Asp 
        675                 680                 685             


Arg Val Gly Phe Val Ala Lys Ala Ile Pro Leu Tyr Phe Ala Glu Glu 
    690                 695                 700                 


Tyr Lys Asp Asn Val Gln Pro Phe Tyr Asp Tyr Pro Phe Asn Ile Gly 
705                 710                 715                 720 


Asn Lys Leu Lys Pro Gln Lys Gly Gln Phe Leu Asp Lys Lys Glu Arg 
                725                 730                 735     


Val Glu Leu Trp Gln Lys Asn Lys Glu Leu Phe Lys Asn Tyr Pro Ser 
            740                 745                 750         


Glu Lys Lys Lys Thr Asp Leu Ala Tyr Leu Asp Phe Leu Ser Trp Lys 
        755                 760                 765             


Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys Asn Gln Asp Ile Val Thr 
    770                 775                 780                 


Trp Leu Met Phe Lys Glu Leu Phe Asn Met Ala Thr Val Glu Gly Leu 
785                 790                 795                 800 


Lys Ile Gly Glu Ile His Leu Arg Asp Ile Asp Thr Asn Thr Ala Lys 
                805                 810                 815     


Ala Glu Ser Asn Asn Ile Leu Asn Arg Ile Met Pro Met Lys Leu Pro 
            820                 825                 830         


Val Lys Thr Tyr Glu Ile Asn Asn Lys Gly Lys Met Glu Met Glu Lys 
        835                 840                 845             


Pro Leu Ala Thr Phe Tyr Ile Glu Glu Thr Glu Thr Lys Val Leu Lys 
    850                 855                 860                 


Gln Gly Asn Phe Lys Ala Leu Val Lys Asp Arg Arg Leu Asn Gly Leu 
865                 870                 875                 880 


Phe Ser Phe Ala Glu Thr Thr Asp Leu Asn Leu Glu Glu His Pro Ile 
                885                 890                 895     


Ser Lys Leu Ser Val Asp His Glu Leu Ile Lys Tyr Gln Thr Thr Arg 
            900                 905                 910         


Val Arg Ile Phe Glu Met Val Leu Arg Leu Glu Lys Lys Leu Ile Asn 
        915                 920                 925             


Lys Tyr Pro Thr Leu Pro Thr Tyr Ser Phe Lys Asn Met Leu Glu Ser 
    930                 935                 940                 


Trp Leu Glu Asp Lys Thr Asn Ser Ala Glu Leu Asn Asn Tyr Val Asp 
945                 950                 955                 960 


Cys Leu Ile Ala Val Arg Asn Ala Phe Ala His Asn Gln Tyr Pro Met 
                965                 970                 975     


Tyr Asn Pro Lys Leu Phe Ala Glu Val Lys Lys Phe Ser Leu Phe Pro 
            980                 985                 990         


Ser Ser Asn Thr Lys Lys Thr Glu  Leu Asn Ile Ala Pro  Gln Leu Leu 
        995                 1000                 1005             


Glu Ile  Val Gly Lys Ala Ile  Lys Glu Ile Glu Lys  Ser Glu Asn 
    1010                 1015                 1020             


Lys Asn  
    1025 


<210>  1669
<211>  1175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (193)..(193)
<223>  Xaa can be any naturally occurring amino acid

<400>  1669

Met Thr Glu Gln Asn Glu Arg Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Ala His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Met Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Xaa Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Cys Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Gly Thr Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Ala Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Gly Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Phe Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Asp Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Gly Glu Ile Asp Thr Arg Asp 
    530                 535                 540                 


Glu Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Glu Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Ser Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Tyr Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Asp Leu Glu Ala Trp Ser His Ser Ala Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Val Gly Ile Glu Tyr Ala Ser Trp Glu Asn 
    850                 855                 860                 


Lys Lys Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Glu Thr 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Lys Ala Asp Lys Ile Asn Ile Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Ala Lys Glu His Pro Tyr Leu Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asp Ile Arg Thr 
945                 950                 955                 960 


Glu Val Gln Glu Gln Gly Ser Leu Asn Val Leu Asn Arg Val Lys Pro 
                965                 970                 975     


Met Arg Leu Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val 
            980                 985                 990         


His Lys Glu Gln Ala Pro Leu Ala  Thr Val Tyr Ile Glu  Glu Arg Asp 
        995                 1000                 1005             


Thr Lys  Leu Leu Lys Gln Gly  Asn Phe Lys Ser Phe  Val Lys Asp 
    1010                 1015                 1020             


Arg Arg  Leu Asn Gly Leu Phe  Ser Phe Val Asp Thr  Gly Ala Leu 
    1025                 1030                 1035             


Ala Met  Glu Gln Tyr Pro Ile  Ser Lys Leu Arg Val  Glu Tyr Glu 
    1040                 1045                 1050             


Leu Ala  Lys Tyr Gln Thr Ala  Arg Val Cys Ala Phe  Glu Gln Thr 
    1055                 1060                 1065             


Leu Glu  Leu Glu Glu Ser Leu  Leu Thr Arg Tyr Pro  His Leu Pro 
    1070                 1075                 1080             


Asp Glu  Ser Phe Arg Glu Met  Leu Glu Ser Trp Ser  Asp Pro Leu 
    1085                 1090                 1095             


Leu Asp  Lys Trp Pro Asp Leu  Gln Arg Glu Val Arg  Leu Leu Ile 
    1100                 1105                 1110             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1115                 1120                 1125             


Glu Thr  Ile Phe Ser Ser Ile  Arg Lys Tyr Asp Pro  Ser Ser Pro 
    1130                 1135                 1140             


Asp Ala  Ile Glu Glu Arg Met  Gly Leu Asn Ile Ala  His Arg Leu 
    1145                 1150                 1155             


Ser Glu  Glu Val Lys Gln Ala  Lys Glu Met Ala Glu  Arg Ile Ile 
    1160                 1165                 1170             


Gln Ala  
    1175 


<210>  1670
<211>  1124
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (121)..(133)
<223>  Xaa can be any naturally occurring amino acid

<400>  1670

Met Glu Lys Pro Arg Gln Arg Ser Gly Glu Glu Ser Ser Ala Glu Lys 
1               5                   10                  15      


Phe Asp Pro Glu Ala Phe Leu Leu Phe Gly Arg Ser Arg Ile Arg Lys 
            20                  25                  30          


Glu Thr Leu Arg Lys Pro Ile Phe Arg Lys Gln Ile Leu Gln Glu Glu 
        35                  40                  45              


Arg Thr His Glu Lys Arg Lys Gly Gly Thr Ala Ser Gln Cys Thr Leu 
    50                  55                  60                  


Leu Gly Gln Ser Glu Glu His Pro Val Arg Leu Ser Ala Lys Ala Gln 
65                  70                  75                  80  


Gly Phe Gln Glu Leu Leu Leu Pro Leu Ser Thr Ser Arg Ile Phe Gly 
                85                  90                  95      


Ile Ala His Val Arg Trp Lys His Ala Ser Glu Thr Val Gln Arg Leu 
            100                 105                 110         


Arg Cys Glu Cys Ala Thr Gly Glu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Xaa Xaa Xaa Xaa Xaa Asp His Glu His Asn Asp Lys Val Asp Pro His 
    130                 135                 140                 


Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp Arg Cys Gly 
145                 150                 155                 160 


Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp Arg Glu Gly 
                165                 170                 175     


Thr Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Glu 
            180                 185                 190         


Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly Phe Lys Gly 
        195                 200                 205             


Gly Thr Glu Ala Tyr Gln Gln Met Thr Asn Glu Val Phe Cys Arg Ser 
    210                 215                 220                 


Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg Thr Asp Asp 
225                 230                 235                 240 


Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys Pro Lys Ser 
                245                 250                 255     


Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe Arg Val Pro 
            260                 265                 270         


Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Gly Gly Thr Glu Glu Asp 
        275                 280                 285             


Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe 
    290                 295                 300                 


Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser Leu Arg Phe 
305                 310                 315                 320 


His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys Lys Asn Ile 
                325                 330                 335     


Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu Tyr Gly Phe 
            340                 345                 350         


Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu Glu Trp Lys 
        355                 360                 365             


Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp Lys Pro Tyr 
    370                 375                 380                 


Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly Lys Ile Gly 
385                 390                 395                 400 


Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser Pro Glu Val 
                405                 410                 415     


Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp Lys Arg Phe 
            420                 425                 430         


Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro Met Met Phe 
        435                 440                 445             


Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Asp Glu Ala Ser Ala Glu 
    450                 455                 460                 


Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val Tyr Ala Val 
465                 470                 475                 480 


Tyr Asp Ala Phe Ala Arg Gly Glu Ile Asp Thr Arg Asp Glu Leu Asp 
                485                 490                 495     


Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu Pro Arg Gln 
            500                 505                 510         


Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu Glu Lys Val 
        515                 520                 525             


Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His Arg Leu Asp 
    530                 535                 540                 


Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly Arg Lys Asn 
545                 550                 555                 560 


Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu Val Arg Asp 
                565                 570                 575     


Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly Lys Pro Leu 
            580                 585                 590         


Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu Gln Arg Ala 
        595                 600                 605             


Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro Tyr Phe Arg 
    610                 615                 620                 


Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe Leu His Glu 
625                 630                 635                 640 


Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr Arg Ser Tyr 
                645                 650                 655     


Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg Ser Asp Arg 
            660                 665                 670         


Glu Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys Thr Asp Arg 
        675                 680                 685             


Gln Thr Leu Val Ala Gly Trp Lys Ser Glu Phe His Leu Pro Arg Gly 
    690                 695                 700                 


Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met Gly Tyr Asp 
705                 710                 715                 720 


Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys Ala Val Pro 
                725                 730                 735     


Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro Phe Tyr Asp 
            740                 745                 750         


Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys Gly Arg Phe 
        755                 760                 765             


Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly Lys Glu Arg 
    770                 775                 780                 


Phe Arg Asp Leu Glu Ala Trp Ser His Ser Ala Ala Arg Arg Ile Glu 
785                 790                 795                 800 


Asp Ala Phe Val Gly Ile Glu Tyr Ala Ser Trp Glu Asn Lys Lys Lys 
                805                 810                 815     


Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Glu Thr Phe Glu Ser 
            820                 825                 830         


Lys Leu Lys Val Lys Ala Asp Lys Ile Asn Ile Ala Lys Leu Lys Lys 
        835                 840                 845             


Glu Ile Leu Glu Ala Lys Glu His Pro Tyr Leu Asp Phe Lys Ser Trp 
    850                 855                 860                 


Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln Asp Ile Ile 
865                 870                 875                 880 


Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys Val Glu Gly 
                885                 890                 895     


Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asp Ile Arg Thr Glu Val Gln 
            900                 905                 910         


Glu Gln Gly Ser Leu Asn Val Leu Asn Arg Val Lys Pro Met Arg Leu 
        915                 920                 925             


Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val His Lys Glu 
    930                 935                 940                 


Gln Ala Pro Leu Ala Thr Val Tyr Ile Glu Glu Arg Asp Thr Lys Leu 
945                 950                 955                 960 


Leu Lys Gln Gly Asn Phe Lys Ser Phe Val Lys Asp Arg Arg Leu Asn 
                965                 970                 975     


Gly Leu Phe Ser Phe Val Asp Thr Gly Ala Leu Ala Met Glu Gln Tyr 
            980                 985                 990         


Pro Ile Ser Lys Leu Arg Val Glu  Tyr Glu Leu Ala Lys  Tyr Gln Thr 
        995                 1000                 1005             


Ala Arg  Val Cys Ala Phe Glu  Gln Thr Leu Glu Leu  Glu Glu Ser 
    1010                 1015                 1020             


Leu Leu  Thr Arg Tyr Pro His  Leu Pro Asp Glu Ser  Phe Arg Glu 
    1025                 1030                 1035             


Met Leu  Glu Ser Trp Ser Asp  Pro Leu Leu Asp Lys  Trp Pro Asp 
    1040                 1045                 1050             


Leu Gln  Arg Glu Val Arg Leu  Leu Ile Ala Val Arg  Asn Ala Phe 
    1055                 1060                 1065             


Ser His  Asn Gln Tyr Pro Met  Tyr Asp Glu Thr Ile  Phe Ser Ser 
    1070                 1075                 1080             


Ile Arg  Lys Tyr Asp Pro Ser  Ser Pro Asp Ala Ile  Glu Glu Arg 
    1085                 1090                 1095             


Met Gly  Leu Asn Ile Ala His  Arg Leu Ser Glu Glu  Val Lys Gln 
    1100                 1105                 1110             


Ala Lys  Glu Met Ala Glu Arg  Ile Ile Gln Ala 
    1115                 1120                 


<210>  1671
<211>  1175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1671

Met Thr Glu Gln Asn Glu Arg Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Ala His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro Leu Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Cys Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Glu Lys Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Ala Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Ile Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Leu Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Glu Glu Val 
            500                 505                 510         


Ser Ala Glu Lys Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Gly Glu Ile Asp Thr Leu Asp 
    530                 535                 540                 


Arg Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Val Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Glu Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Gly Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly His Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asn Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Glu Arg Ile Lys Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Asp Leu Glu Ala Trp Ser His Ser Val Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Ala Gly Ile Lys Tyr Ala Ser Pro Gly Asn 
    850                 855                 860                 


Lys Lys Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Glu Thr 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Lys Ala Asp Lys Ile Asn Leu Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Ala Lys Glu His Pro Tyr Leu Asp Phe 
            900                 905                 910         


Lys Ser Cys Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asp Ile Trp Thr 
945                 950                 955                 960 


Asp Val His Glu Gln Gly Ser Leu Asn Val Leu Asn Arg Val Lys Pro 
                965                 970                 975     


Met Arg Leu Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val 
            980                 985                 990         


His Lys Glu Gln Ala Pro Leu Ala  Thr Val Tyr Ile Glu  Glu Arg Asp 
        995                 1000                 1005             


Thr Lys  Leu Leu Lys Gln Gly  Asn Phe Lys Ser Phe  Val Lys Asp 
    1010                 1015                 1020             


Arg Arg  Leu Asn Gly Leu Phe  Ser Phe Val Asp Thr  Gly Gly Leu 
    1025                 1030                 1035             


Ala Met  Glu Gln Tyr Pro Ile  Ser Lys Leu Arg Val  Glu Tyr Glu 
    1040                 1045                 1050             


Leu Ala  Lys Tyr Gln Thr Ala  Arg Val Cys Ala Phe  Glu Gln Thr 
    1055                 1060                 1065             


Leu Glu  Leu Glu Glu Ser Leu  Leu Thr Arg Cys Pro  His Leu Pro 
    1070                 1075                 1080             


Asp Lys  Asn Phe Arg Glu Met  Leu Glu Ser Trp Ser  Asp Pro Leu 
    1085                 1090                 1095             


Leu Asp  Lys Trp Pro Asp Leu  His Gly Asn Val Arg  Leu Leu Ile 
    1100                 1105                 1110             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1115                 1120                 1125             


Glu Ala  Val Phe Ser Ser Ile  Arg Lys Tyr Asp Pro  Ser Ser Pro 
    1130                 1135                 1140             


Asp Ala  Ile Glu Glu Arg Met  Gly Leu Asn Ile Ala  His Arg Leu 
    1145                 1150                 1155             


Ser Glu  Glu Val Lys Gln Ala  Lys Glu Thr Val Glu  Arg Ile Ile 
    1160                 1165                 1170             


Gln Ala  
    1175 


<210>  1672
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1672

Leu Gln Lys Gln Asp Lys Leu Phe Val Asp Arg Lys Lys Asn Ala Ile 
1               5                   10                  15      


Phe Ala Phe Pro Lys Tyr Ile Thr Ile Met Glu Asn Gln Glu Lys Pro 
            20                  25                  30          


Glu Pro Ile Tyr Tyr Glu Leu Thr Asp Lys His Phe Trp Ala Ala Phe 
        35                  40                  45              


Leu Asn Leu Ala Arg His Asn Val Tyr Thr Thr Ile Asn His Ile Asn 
    50                  55                  60                  


Arg Arg Leu Glu Ile Ala Glu Leu Lys Asp Asp Gly Tyr Met Met Gly 
65                  70                  75                  80  


Ile Lys Gly Ser Trp Asn Glu Gln Ala Lys Lys Leu Asp Lys Lys Val 
                85                  90                  95      


Arg Leu Arg Asp Leu Ile Met Lys His Phe Pro Phe Leu Glu Ala Ala 
            100                 105                 110         


Ala Tyr Glu Ile Thr Asn Ser Lys Ser Pro Asn Asn Lys Glu Gln Arg 
        115                 120                 125             


Glu Lys Glu Gln Ser Glu Ala Leu Ser Leu Asn Asn Leu Lys Asn Val 
    130                 135                 140                 


Leu Phe Ile Phe Leu Glu Lys Leu Gln Val Leu Arg Asn Tyr Tyr Ser 
145                 150                 155                 160 


His Tyr Lys Tyr Ser Glu Glu Ser Pro Lys Pro Ile Phe Glu Thr Ser 
                165                 170                 175     


Leu Leu Lys Asn Met Tyr Lys Val Phe Asp Ala Asn Val Arg Leu Val 
            180                 185                 190         


Lys Arg Asp Tyr Met His His Glu Asn Ile Asp Met Gln Arg Asp Phe 
        195                 200                 205             


Thr His Leu Asn Arg Lys Lys Gln Val Gly Arg Thr Lys Asn Ile Ile 
    210                 215                 220                 


Asp Ser Pro Asn Phe His Tyr His Phe Ala Asp Lys Glu Gly Asn Met 
225                 230                 235                 240 


Thr Ile Ala Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Asp Lys Lys 
                245                 250                 255     


Asp Ala Ile Trp Met Gln Lys Lys Leu Lys Gly Phe Lys Asp Gly Arg 
            260                 265                 270         


Asn Leu Arg Glu Gln Met Thr Asn Glu Val Phe Cys Arg Ser Arg Ile 
        275                 280                 285             


Ser Leu Pro Lys Leu Lys Leu Glu Asn Val Gln Thr Lys Asp Trp Met 
    290                 295                 300                 


Gln Leu Asp Met Leu Asn Glu Leu Val Arg Cys Pro Lys Ser Leu Tyr 
305                 310                 315                 320 


Glu Arg Leu Arg Glu Lys Asp Arg Glu Ser Phe Lys Val Pro Phe Asp 
                325                 330                 335     


Ile Phe Ser Asp Asp Tyr Asp Ala Glu Glu Glu Pro Phe Lys Asn Thr 
            340                 345                 350         


Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe 
        355                 360                 365             


Asp Leu Asn Glu Ile Phe Glu Gln Leu Arg Phe Gln Ile Asp Leu Gly 
    370                 375                 380                 


Thr Tyr His Phe Ser Ile Tyr Asn Lys Arg Ile Gly Asp Glu Asp Glu 
385                 390                 395                 400 


Val Arg His Leu Thr His His Leu Tyr Gly Phe Ala Arg Ile Gln Asp 
                405                 410                 415     


Phe Ala Pro Gln Asn Gln Pro Glu Glu Trp Arg Lys Leu Val Lys Asp 
            420                 425                 430         


Leu Asp His Phe Glu Thr Ser Gln Glu Pro Tyr Ile Ser Lys Thr Ala 
        435                 440                 445             


Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Lys Phe Cys Ser 
    450                 455                 460                 


Thr His Asn Asn Leu Phe Pro Ser Leu Lys Arg Glu Lys Thr Cys Asn 
465                 470                 475                 480 


Gly Arg Ser Lys Phe Asn Leu Gly Thr Gln Phe Thr Ala Glu Ala Phe 
                485                 490                 495     


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu 
            500                 505                 510         


Thr Lys Asp Tyr Ser Arg Lys Glu Ser Ala Asp Lys Val Glu Gly Ile 
        515                 520                 525             


Ile Arg Lys Glu Ile Ser Asn Ile Tyr Ala Ile Tyr Asp Ala Phe Ala 
    530                 535                 540                 


Asn Asn Glu Ile Asn Ser Ile Ala Asp Leu Thr Cys Arg Leu Gln Lys 
545                 550                 555                 560 


Thr Asn Ile Leu Gln Gly His Leu Pro Lys Gln Met Ile Ser Ile Leu 
                565                 570                 575     


Glu Gly Arg Gln Lys Asp Met Glu Lys Glu Ala Glu Arg Lys Ile Gly 
            580                 585                 590         


Glu Met Ile Asp Asp Thr Gln Arg Arg Leu Asp Leu Leu Cys Lys Gln 
        595                 600                 605             


Thr Asn Gln Lys Ile Arg Ile Gly Lys Arg Asn Ala Gly Leu Leu Lys 
    610                 615                 620                 


Ser Gly Lys Ile Ala Asp Trp Leu Val Ser Asp Met Met Arg Phe Gln 
625                 630                 635                 640 


Pro Val Gln Lys Asp Thr Asn Asn Ala Pro Ile Asn Asn Ser Lys Ala 
                645                 650                 655     


Asn Ser Thr Glu Tyr Arg Met Leu Gln His Ala Leu Ala Leu Phe Gly 
            660                 665                 670         


Ser Glu Ser Ser Arg Leu Lys Ala Tyr Phe Arg Gln Met Asn Leu Val 
        675                 680                 685             


Gly Asn Ala Asn Pro His Pro Phe Leu Ala Glu Thr Gln Trp Glu His 
    690                 695                 700                 


Gln Thr Asn Ile Leu Ser Phe Tyr Arg Asn Tyr Leu Glu Ala Arg Lys 
705                 710                 715                 720 


Lys Tyr Leu Lys Gly Leu Lys Pro Gln Asn Trp Lys Gln Tyr Gln His 
                725                 730                 735     


Phe Leu Ile Leu Lys Val Gln Lys Thr Asn Arg Asn Thr Leu Val Thr 
            740                 745                 750         


Gly Trp Lys Asn Ser Phe Asn Leu Pro Arg Gly Ile Phe Thr Gln Pro 
        755                 760                 765             


Ile Arg Glu Trp Phe Glu Lys His Asn Asn Ser Lys Arg Ile Tyr Asp 
    770                 775                 780                 


Gln Ile Leu Ser Phe Asp Arg Val Gly Phe Val Ala Lys Ala Ile Pro 
785                 790                 795                 800 


Leu Tyr Phe Ala Glu Glu Tyr Lys Asp Asn Val Gln Pro Phe Tyr Asp 
                805                 810                 815     


Tyr Pro Phe Asn Ile Gly Asn Lys Leu Lys Pro Gln Lys Gly Gln Phe 
            820                 825                 830         


Leu Asp Lys Lys Glu Arg Val Glu Leu Trp Gln Lys Asn Lys Glu Leu 
        835                 840                 845             


Phe Lys Asn Tyr Pro Ser Glu Lys Asn Lys Thr Asp Leu Ala Tyr Leu 
    850                 855                 860                 


Asp Phe Leu Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys 
865                 870                 875                 880 


Asn Gln Asp Ile Val Thr Trp Leu Met Phe Lys Glu Leu Phe Lys Thr 
                885                 890                 895     


Thr Thr Val Glu Gly Leu Lys Ile Gly Glu Ile His Leu Arg Asp Ile 
            900                 905                 910         


Asp Thr Asn Thr Ala Asn Glu Glu Ser Asn Asn Ile Leu Asn Arg Ile 
        915                 920                 925             


Met Pro Met Lys Leu Pro Val Lys Thr Tyr Glu Thr Asp Asn Lys Gly 
    930                 935                 940                 


Asn Ile Leu Lys Glu Arg Pro Leu Ala Thr Phe Tyr Ile Glu Glu Thr 
945                 950                 955                 960 


Glu Thr Lys Val Leu Lys Gln Gly Asn Phe Lys Val Leu Ala Lys Asp 
                965                 970                 975     


Arg Arg Leu Asn Gly Leu Leu Ser Phe Ala Glu Thr Thr Asp Ile Asp 
            980                 985                 990         


Leu Glu Lys Asn Pro Ile Thr Lys  Leu Ser Val Asp Tyr  Glu Leu Ile 
        995                 1000                 1005             


Lys Tyr  Gln Thr Thr Arg Ile  Ser Ile Phe Glu Met  Thr Leu Gly 
    1010                 1015                 1020             


Leu Glu  Lys Lys Leu Ile Asp  Lys Tyr Ser Thr Leu  Pro Thr Asp 
    1025                 1030                 1035             


Ser Phe  Arg Asn Met Leu Glu  Arg Trp Leu Gln Cys  Lys Ala Asn 
    1040                 1045                 1050             


Arg Pro  Glu Leu Lys Asn Tyr  Val Asn Ser Leu Ile  Ala Val Arg 
    1055                 1060                 1065             


Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met Tyr Asp  Ala Thr Leu 
    1070                 1075                 1080             


Phe Ala  Glu Val Lys Lys Phe  Thr Leu Phe Pro Ser  Val Asp Thr 
    1085                 1090                 1095             


Lys Lys  Ile Glu Leu Asn Ile  Ala Pro Gln Leu Leu  Glu Ile Val 
    1100                 1105                 1110             


Gly Lys  Ala Ile Lys Glu Ile  Glu Lys Ser Glu Asn  Lys Asn 
    1115                 1120                 1125         


<210>  1673
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1673

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Ala Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Leu Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1674
<211>  1319
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1674

Met Gly Lys Glu His Lys Gly Asn Asn Ala Pro Lys Asn Arg Asn Lys 
1               5                   10                  15      


Val Ala Asn Asn Ser Gln Gln Pro Arg Lys Val Arg Arg Leu Gln Lys 
            20                  25                  30          


Thr Asn Phe Arg Ile Ser Leu Ser Gly Lys His Val Phe Gly Ala Tyr 
        35                  40                  45              


Phe Asn Met Ala Arg Thr Asn Phe Ile Lys Thr Ile Asn Tyr Ile Leu 
    50                  55                  60                  


Pro Ile Ala Gly Val Arg Gly Asn Tyr Ser Glu Ser Gln Ile Asn Lys 
65                  70                  75                  80  


Leu Leu Gln Ala Met Phe Leu Ile Gln Thr Gly Arg Asn Gly Glu Leu 
                85                  90                  95      


Thr Lys Glu Gln Lys Gln Trp Glu Lys Lys Leu Arg Leu Asn Pro Glu 
            100                 105                 110         


Gln Gln Thr Lys Leu Gln Gln Leu Leu Phe Lys His Phe Pro Val Leu 
        115                 120                 125             


Gly Pro Met Met Ala Asp Val Ala Asp His Lys Val Tyr Leu Asn Lys 
    130                 135                 140                 


Lys Lys Ser Asn Val Gln Thr Glu Asp Glu Ala Phe Ala Gln Leu Lys 
145                 150                 155                 160 


Gly Val Ser Leu Ala Asp Cys Leu Glu Met Ile Tyr Leu Met Ala Glu 
                165                 170                 175     


Thr Leu Thr Glu Cys Arg Asn Phe Tyr Thr His Lys Ser Pro Tyr Asn 
            180                 185                 190         


Thr Pro Ser Gln Leu Ala Met Gln Tyr Leu His Gln Glu Met Ile Ala 
        195                 200                 205             


Lys Lys Leu Asp Lys Val Val Val Ala Ser Arg Arg Ile Leu Lys Asp 
    210                 215                 220                 


Arg Glu Gly Leu Ser Val Asn Glu Met Glu Phe Leu Thr Gly Ile Asp 
225                 230                 235                 240 


His Leu His Gln Glu Thr Val Lys Asp Glu Tyr Gly Asn Val Lys Met 
                245                 250                 255     


Lys Asp Gly Lys Val Met Lys Thr Phe Val Glu Tyr Asp Asp Phe Tyr 
            260                 265                 270         


Phe Lys Ile Ser Gly Lys Arg Leu Val Lys Gly Phe Thr Val Thr Gly 
        275                 280                 285             


Lys Asp Gly Lys Pro Ile Asn Val Asp Thr Met Leu Pro Ala Leu Ser 
    290                 295                 300                 


Asp Phe Gly Leu Leu Tyr Phe Cys Val Ile Phe Leu Ser Lys Pro Tyr 
305                 310                 315                 320 


Ala Lys Leu Phe Ile Asp Glu Val Arg Leu Phe Glu Phe Ser Pro Phe 
                325                 330                 335     


Ser Asp Asn Glu Asn Met Ile Met Ser Glu Met Leu Ser Ile Tyr Arg 
            340                 345                 350         


Ile Arg Thr Pro Arg Leu His Lys Ile Asp Ser Arg Asp Ser Lys Ala 
        355                 360                 365             


Thr Leu Ala Met Asp Ile Phe Gly Glu Leu Arg Arg Cys Pro Ile Glu 
    370                 375                 380                 


Leu Tyr Asn Leu Leu Asp Lys Asn Ser Gly Gln Pro Phe Phe His Asp 
385                 390                 395                 400 


Glu Val Lys Arg Pro Asn Ser His Thr Pro Glu Val Ser Lys Arg Leu 
                405                 410                 415     


Arg Tyr Asn Asp Arg Phe Pro Thr Leu Ala Leu Arg Tyr Val Asp Glu 
            420                 425                 430         


Thr Glu Leu Phe Lys Arg Ile Arg Phe Gln Leu Gln Leu Gly Ala Phe 
        435                 440                 445             


Arg Tyr Lys Phe Tyr Asp Lys Glu Gly Ile Asp Gly Arg Ile Arg Val 
    450                 455                 460                 


Arg Arg Ile Gln Lys Asp Ile Asn Gly Tyr Gly Arg Leu Gln Glu Val 
465                 470                 475                 480 


Ala Asp Lys Arg Ile Glu Lys Trp Gly Asp Met Leu Gln Lys Arg Glu 
                485                 490                 495     


Glu Arg Ser Val Lys Leu Glu His Glu Glu Leu Tyr Ile Asp Leu Asp 
            500                 505                 510         


Gln Phe Gln Glu Asp Thr Ala Asp Ser Thr Pro Tyr Val Thr Asp Arg 
        515                 520                 525             


Arg Pro Val Tyr Asn Ile His Ala Asn Arg Ile Gly Leu Tyr Trp Glu 
    530                 535                 540                 


Glu Ser Gln Asn Pro Asn Glu Phe Lys Val Phe Asp Asn Asn Gly Met 
545                 550                 555                 560 


Tyr Ile Pro Glu Leu Val Val Thr Glu Asp Glu Lys Ala Pro Val Lys 
                565                 570                 575     


Met Pro Ala Pro Arg Cys Ala Leu Ser Val Tyr Asp Leu Ser Ala Met 
            580                 585                 590         


Leu Phe Tyr Glu Tyr Leu Arg Glu Gln Glu Asp Gly Asn Ile Pro Ser 
        595                 600                 605             


Ala Glu Gln Ile Ile Ile Asp Tyr Glu Ala Asp Tyr Arg Arg Phe Phe 
    610                 615                 620                 


Asn Ala Val Ala Glu Gly Thr Leu Lys Pro Phe Gln Lys Thr Lys Asp 
625                 630                 635                 640 


Phe Arg Glu Tyr Leu Glu Lys Glu Tyr Pro Arg Leu Arg Met Glu Asp 
                645                 650                 655     


Ile Pro Glu Lys Leu Gln Leu Tyr Leu Thr Cys Lys Gly Leu Thr His 
            660                 665                 670         


Asp Asn Lys Pro Glu Thr Val Arg Glu Arg Met Ile Arg Leu Ala Ile 
        675                 680                 685             


Glu His Leu Lys Glu Arg Glu Glu Arg Val Gln Arg Arg Leu Glu His 
    690                 695                 700                 


Tyr Glu Glu Asp Arg Lys Met Ile Gly Glu Lys Asp Asn Lys Tyr Gly 
705                 710                 715                 720 


Lys Lys Gly Phe Ala Asp Val Arg His Gly Ala Ile Ala Arg Tyr Leu 
                725                 730                 735     


Ala Gln Ser Met Met Glu Trp Gln Pro Thr Asn Leu Lys Asp Lys Glu 
            740                 745                 750         


Lys Gly Arg Asp Lys Leu Thr Gly Met Asn Tyr Asn Val Leu Thr Ala 
        755                 760                 765             


Tyr Leu Ala Thr Phe Gly Gln Pro Gln Thr Pro Glu Glu Asp Phe Thr 
    770                 775                 780                 


Pro Arg Thr Leu Glu Gln Val Leu Thr Gly Ala His Leu Ile Gly Gly 
785                 790                 795                 800 


Asn Asn Pro His Pro Phe Ile Asp Lys Val Leu Ala Leu Gly Asn Arg 
                805                 810                 815     


Asn Ile Glu Glu Leu Tyr Leu His Tyr Leu Glu Glu Glu Leu Lys His 
            820                 825                 830         


Ile Arg Ser Arg Lys Gln Ser Leu Ser Ser Asn Pro Ser Asp Lys Asp 
        835                 840                 845             


Leu Ser Ala Leu Pro Phe Val His His Asp His Leu Arg Phe His Glu 
    850                 855                 860                 


Arg Thr Asn Glu Glu Met Arg Ala Leu Ala Ala Arg Tyr Thr Thr Ile 
865                 870                 875                 880 


Gln Leu Pro Asp Gly Leu Phe Thr Pro Tyr Ile Val Glu Leu Leu Lys 
                885                 890                 895     


Gln Tyr Val Glu Leu Gln Thr Ala Leu Asn Gln Asp Ile Pro Ala Asn 
            900                 905                 910         


Leu Asn Pro Thr Asn Asn Ala Ala Tyr Leu Ile Thr Gln Phe Tyr Gln 
        915                 920                 925             


Thr Ile Leu Lys Asp Asp Ala Gln Pro Phe Tyr Ile Ser Gly Lys Thr 
    930                 935                 940                 


Tyr Thr Arg His Lys Glu Gly Glu Lys Asp Glu Val Phe Ser Phe Lys 
945                 950                 955                 960 


Arg Ala Tyr Glu Leu Phe Ser Val Leu Asn Asn Glu Lys Lys Arg Thr 
                965                 970                 975     


Phe Pro Phe Glu Leu Ile Pro Leu Phe Leu Thr Ser Glu Glu Ile Gln 
            980                 985                 990         


Lys Arg Leu Ser Glu Lys Leu Leu  Asp Asp Asp Gly Asn  Thr Met Pro 
        995                 1000                 1005             


Glu Gln  Gly Lys Arg Gly Lys  Ala Ala Thr Asp Ser  Gln Gly Asn 
    1010                 1015                 1020             


Ile Ile  Trp Gln Arg Lys Ile  Lys Leu Asp Ile Ser  Asn Tyr Val 
    1025                 1030                 1035             


Ser Ser  Leu Ser Asp Lys Asp  Leu Lys Ile Ser Met  Asn Gln Ser 
    1040                 1045                 1050             


Trp Lys  Gln Lys Glu Glu Glu  Arg Thr Glu Lys Arg  Glu Ala Leu 
    1055                 1060                 1065             


Gln Ser  Arg Leu Thr Arg Gln  Ile His Asp Ile Lys  Tyr Asn Glu 
    1070                 1075                 1080             


Arg Thr  Leu Arg Arg Tyr Lys  Thr Gln Asp Met Val  Leu Phe Leu 
    1085                 1090                 1095             


Ile Ala  Lys Lys Leu Phe Glu  Asn Ile Ile Phe Glu  Gln Gly Asn 
    1100                 1105                 1110             


Glu Val  Asn Ser Glu Gln Met  Arg Leu Ser Lys Val  Cys Asp Glu 
    1115                 1120                 1125             


Ala Phe  Leu Arg Gln Thr Leu  Thr Phe Arg Val Pro  Val Thr Val 
    1130                 1135                 1140             


Gly Asp  Lys Thr Ile Tyr Val  Glu Gln Glu Asn Met  Ser Leu Lys 
    1145                 1150                 1155             


Asn Tyr  Gly Glu Phe Tyr Arg  Phe Leu Thr Asp Asp  Arg Leu Met 
    1160                 1165                 1170             


Ser Leu  Leu Glu Asn Ile Ile  Gly Thr Leu Lys Pro  Asn Glu Asp 
    1175                 1180                 1185             


Gly Asp  Leu Val Ile Arg His  Thr Asp Leu Met Ser  Glu Leu Ala 
    1190                 1195                 1200             


Ala Tyr  Asp Gln His Arg Ser  Thr Val Phe Lys Leu  Ile Gln Gln 
    1205                 1210                 1215             


Ile Glu  Asn Leu Ile Ile Glu  Lys Asn Ala Ala Leu  Lys Asn Pro 
    1220                 1225                 1230             


Asp Ser  Glu Asp Phe Trp Val  Lys Glu Gly Leu Pro  Lys Arg Asn 
    1235                 1240                 1245             


Asn Phe  Ala Ser Leu Leu Glu  Leu Ile Asp Gln Leu  Asn Asn Val 
    1250                 1255                 1260             


Ala Leu  Thr Asp Glu Glu Arg  Lys Leu Leu Val Ala  Val Arg Asn 
    1265                 1270                 1275             


Ala Phe  Ser His Asn Ser Tyr  Asn Ile Asp Phe Ser  Leu Ile Lys 
    1280                 1285                 1290             


Asp Val  Lys His Leu Pro Glu  Val Ala Lys Gly Ile  Leu Gln His 
    1295                 1300                 1305             


Leu Glu  Ser Val Val Gly Val  Glu Gln Thr Lys 
    1310                 1315                 


<210>  1675
<211>  1088
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1675

Met Lys Ile Pro Asp Leu Ile Asn Asn Tyr Lys Glu Gln Phe Gly Thr 
1               5                   10                  15      


Tyr Ala Val Met Ala Leu Met Asn Ala Gln Thr Val Leu Asp His Ile 
            20                  25                  30          


Gln Lys Leu Ala Cys Ile Gly Asn Ser Glu Ser Tyr Lys Glu Asp Leu 
        35                  40                  45              


Trp Lys His Pro Val Met Leu His Ile Lys Asn Ala Ala Tyr Glu Thr 
    50                  55                  60                  


Asp Asn Asn Pro Glu Thr Thr Leu Phe Val Met Glu Lys Leu Gln Phe 
65                  70                  75                  80  


Tyr Phe Pro Phe Leu Lys Ile Met Ala Glu Arg Gln Arg Glu Tyr Ser 
                85                  90                  95      


Asn Lys Lys Tyr Asn Glu Asn Arg Leu Ala Val Asn Ser Arg Asp Leu 
            100                 105                 110         


Phe Phe Val Leu Asp Lys Val Phe Arg Val Leu Lys Asn Tyr Arg Asn 
        115                 120                 125             


Thr Thr Ala His Phe Met Thr Lys Ser Leu Ser Glu Asn Glu Glu Tyr 
    130                 135                 140                 


Leu Phe Leu Lys Asn Glu Gln Pro Leu Ala Asn Met Val Asn Glu Tyr 
145                 150                 155                 160 


Tyr Thr Val Ala Leu Arg Asp Met Lys Asp Arg Tyr Ser Tyr Ser Thr 
                165                 170                 175     


Glu Asp Leu Ala Phe Ile Gln Asp Asn Arg Tyr Lys Gln Thr Arg Gly 
            180                 185                 190         


Asp Asp Gly Lys Arg Lys Ala Thr Val Asn Leu Asp Phe Phe Leu Ser 
        195                 200                 205             


Leu Gln Ser His Asn Gly Asp Pro Ala Lys Lys Leu His Leu Ser Gly 
    210                 215                 220                 


Val Gly Val Ala Leu Leu Ile Cys Leu Phe Leu Glu Lys Gln Tyr Val 
225                 230                 235                 240 


Asn Leu Phe Ile Ser Lys Leu Ser Ile Phe Ser Thr Tyr Lys Pro Asn 
                245                 250                 255     


Ser Glu Gln His Arg Ile Ile Cys Arg Ser Met Gly Ile His Ser Ile 
            260                 265                 270         


Lys Leu Pro Lys Asp Arg Ile His Ser Leu Lys Asp Gly Met Ser Val 
        275                 280                 285             


Ala Met Asp Met Leu Asn Glu Thr Lys Arg Cys Pro Lys Glu Leu Phe 
    290                 295                 300                 


Asp Thr Leu Ser Ala Asp Lys Gln Ala Arg Phe Arg Thr Ile Ser Asp 
305                 310                 315                 320 


Asp His Asn Glu Val Leu Leu Met Arg Ser Ser Asp Arg Phe Ala Gln 
                325                 330                 335     


Leu Leu Leu Gln Tyr Ile Asp Tyr Asn Lys Leu Phe Lys Gly Ile Arg 
            340                 345                 350         


Phe His Val Asn Met Gly Lys Leu Arg Tyr Leu Phe Asn Ala Ala Lys 
        355                 360                 365             


Asn Cys Ile Asp Gly Gln Thr Arg Val Arg Val Ile Glu His Gln Leu 
    370                 375                 380                 


Asn Gly Tyr Gly Arg Ile Asp Glu Ile Glu Ala Glu Arg Lys Ser Glu 
385                 390                 395                 400 


Asp Gly Lys Phe Ala Asn Ser Gly Ile Ser Ile Arg Asp Phe Glu Asn 
                405                 410                 415     


Val Arg Arg Asp Asp Gly Asn Pro Glu Asn Tyr Pro Tyr Val Val Asp 
            420                 425                 430         


Thr Tyr Ser His Tyr Ile Leu Glu Asn Asn Lys Val Glu Met Gln Phe 
        435                 440                 445             


Thr Asp Ser Cys Ile Leu Pro Phe Ile Glu Glu Tyr Gly Gly Lys Trp 
    450                 455                 460                 


Tyr Val Ala Lys Asp Val Pro Ala Cys Arg Ile Ser Thr Leu Glu Leu 
465                 470                 475                 480 


Pro Ala Leu Ala Phe His Met Leu Leu Leu Gly Ser Lys Lys Thr Glu 
                485                 490                 495     


Glu Arg Ile Lys Glu Val Tyr Gly Lys Tyr Met Lys Leu Phe Glu Ala 
            500                 505                 510         


Met Ser Asn Asp Ala Val Thr Lys Glu Asn Ile Glu Ser Phe Gly Ile 
        515                 520                 525             


Ala Leu Trp Asn Leu Pro Gln Lys Ala Ile Asp Ala Ile Asn Gly Cys 
    530                 535                 540                 


Ala His Ala Lys Asn Val Asn Ala Phe Ile Lys Asn Thr Val Glu Glu 
545                 550                 555                 560 


Met Leu Ala Asp Thr Glu Lys Arg Leu Glu Arg Leu Lys Glu Asp Arg 
                565                 570                 575     


Lys Gly Ile Ser Ser His Asp Asn Lys Met Gly Lys Pro Asn Phe Arg 
            580                 585                 590         


Gln Ile Ser Thr Gly Arg Leu Ala Asp Phe Leu Ala Lys Asp Ile Val 
        595                 600                 605             


Lys Leu Gln Pro Ala Thr Thr Glu Asp Gly Ser Asp Lys Met Thr Gly 
    610                 615                 620                 


Leu Asn Tyr Arg Val Met Gln Ala Ala Ile Ala Thr Tyr Asn Ser Asn 
625                 630                 635                 640 


Gly Asn Pro Glu Ala Glu Gln Gln Phe Arg Gly Met Phe Glu Lys Ala 
                645                 650                 655     


Arg Leu Ile Gly Lys Ser Pro Asn Ala His Pro Phe Leu Tyr Lys Val 
            660                 665                 670         


Phe Ala Ser Ala Leu Pro Lys Asn Thr Ile Glu Phe Tyr Asp Lys Tyr 
        675                 680                 685             


Leu Arg Glu Arg Lys Arg Tyr Leu Ser Asn Leu Thr Lys Asp Ile Glu 
    690                 695                 700                 


Ser Gly Lys Thr Ala Ser Val Pro Phe Val Asn Arg Asn Gln Asn Lys 
705                 710                 715                 720 


Trp Lys Lys Pro Asn Gln Glu Tyr Leu Gly Gln Thr Tyr Gly Asn Ser 
                725                 730                 735     


Gln Asn Leu Ala Ile Glu Leu Pro Arg Gln Met Phe Asp Ala Asp Ile 
            740                 745                 750         


Lys Ala Phe Leu Lys Gly Leu Pro Glu Met Lys Asp Val Asp Phe Asp 
        755                 760                 765             


Asn Ala Asn Val Thr Phe Leu Ile Gly Glu Tyr Met Lys Arg Val Leu 
    770                 775                 780                 


Ala Asp Asp Phe Gln Asn Phe Tyr Ala Trp Lys Arg Asn Tyr Arg Tyr 
785                 790                 795                 800 


Met Asp Met Leu Met Gly Glu Thr Asp Ser Lys Asp Gly Leu Arg His 
                805                 810                 815     


Met Phe Thr Ser Val Glu Glu Arg Glu Lys Leu Trp Arg Glu Arg Glu 
            820                 825                 830         


Gly Arg Thr Ser Ser Tyr Arg Lys Trp Ala Ala Arg Lys Asn Gln Gly 
        835                 840                 845             


Cys Gly Tyr Ser Lys Arg Leu Pro Asp Asn Val Leu Asp Glu Ile Leu 
    850                 855                 860                 


Ala Lys Arg Leu Ser Gly Ser Arg Asn Asp Tyr Gln Lys Cys Glu Lys 
865                 870                 875                 880 


Ala Ile Arg Arg Gln Lys Val Gln Asp Ala Met Leu Phe Met Leu Ala 
                885                 890                 895     


Lys Lys Ala Phe Thr Gln His Ala Asp Phe Glu Gly Lys Asp Phe Lys 
            900                 905                 910         


Leu Lys Asn Ile Met Pro Asp Ala Asp Lys Gly Ile Leu Ser Glu Thr 
        915                 920                 925             


Met Pro Met Thr Phe Thr Phe Glu Lys Gly Gly Lys Gln Tyr Thr Ile 
    930                 935                 940                 


Glu Ser Gly Gly Met Lys Leu Lys Asn Tyr Gly Asp Phe His Ala Leu 
945                 950                 955                 960 


Ala Asn Asp Arg Arg Ile Gly Cys Leu Met Lys Leu Ile Gly Thr Asn 
                965                 970                 975     


Thr Ala Gln Lys Glu Asp Leu Ile Ser Glu Phe Asn Lys Tyr Asp Gln 
            980                 985                 990         


Cys Arg Pro Gln Val Val Lys Leu  Val Leu Asp Leu Glu  Lys Trp Ala 
        995                 1000                 1005             


Phe Ala  Lys Tyr Pro Glu Leu  Gly Ala Ser Glu Glu  Met Ser Tyr 
    1010                 1015                 1020             


Val Ser  Phe Asp Lys Ile Leu  Asn Lys Leu Thr Gln  His Arg Asn 
    1025                 1030                 1035             


Leu Gly  Asn Arg Gln Ser Asn  Ile Leu Arg Lys Ile  Arg Asn Ala 
    1040                 1045                 1050             


Phe Asp  His Asn Ser Tyr Pro  Glu Ser Gly Ile Val  Glu Ile Thr 
    1055                 1060                 1065             


Thr Leu  Pro Glu Ile Ala Gln  Asn Met Lys Asp Met  Phe Gly Arg 
    1070                 1075                 1080             


Tyr Ala  Ile Val Lys 
    1085             


<210>  1676
<211>  1088
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1676

Met Lys Ile Pro Asp Leu Ile Asn Asn Tyr Lys Glu Gln Phe Gly Thr 
1               5                   10                  15      


Tyr Ala Val Met Ala Leu Met Asn Ala Gln Thr Val Leu Asp His Ile 
            20                  25                  30          


Gln Lys Leu Ala Cys Ile Gly Asn Ser Glu Ser Tyr Lys Glu Asp Leu 
        35                  40                  45              


Trp Lys His Pro Val Met Leu His Ile Lys Asn Ala Ala Tyr Glu Thr 
    50                  55                  60                  


Asp Asn Asn Pro Glu Thr Thr Leu Phe Val Met Glu Lys Leu Gln Phe 
65                  70                  75                  80  


Tyr Phe Pro Phe Leu Lys Ile Met Ala Glu Arg Gln Arg Glu Tyr Ser 
                85                  90                  95      


Asn Lys Lys Tyr Asn Glu Asn Arg Leu Ala Val Asn Ser Arg Asp Leu 
            100                 105                 110         


Phe Phe Val Leu Asp Lys Val Phe Arg Val Leu Lys Asn Tyr Arg Asn 
        115                 120                 125             


Thr Thr Ala His Phe Met Thr Lys Ser Leu Ser Glu Asn Glu Glu Tyr 
    130                 135                 140                 


Leu Phe Leu Lys Asn Glu Gln Pro Leu Ala Asn Met Val Asn Glu Tyr 
145                 150                 155                 160 


Tyr Thr Val Ala Leu Arg Asp Met Lys Asp Arg Tyr Ser Tyr Ser Thr 
                165                 170                 175     


Glu Asp Leu Ala Phe Ile Gln Asp Asn Arg Tyr Lys Gln Thr Arg Gly 
            180                 185                 190         


Asp Asp Gly Lys Arg Lys Ala Thr Val Asn Leu Asp Phe Phe Leu Ser 
        195                 200                 205             


Leu Gln Ser His Asn Gly Asp Pro Ala Lys Lys Leu His Leu Ser Gly 
    210                 215                 220                 


Val Gly Val Ala Leu Leu Ile Cys Leu Phe Leu Glu Lys Gln Tyr Val 
225                 230                 235                 240 


Asn Leu Phe Ile Ser Lys Leu Ser Ile Phe Ser Thr Tyr Lys Pro Asn 
                245                 250                 255     


Ser Glu Gln His Arg Ile Ile Cys Arg Ser Met Gly Ile His Ser Ile 
            260                 265                 270         


Lys Leu Pro Lys Asp Arg Ile His Ser Leu Lys Asp Gly Met Ser Val 
        275                 280                 285             


Ala Met Asp Met Leu Asn Glu Thr Lys Arg Cys Pro Lys Glu Leu Phe 
    290                 295                 300                 


Asp Thr Leu Ser Ala Asp Lys Gln Ala Arg Phe Arg Thr Ile Ser Asp 
305                 310                 315                 320 


Asp His Asn Glu Val Leu Leu Met Arg Ser Ser Asp Arg Phe Ala Gln 
                325                 330                 335     


Leu Leu Leu Gln Tyr Ile Asp Tyr Asn Lys Leu Phe Lys Gly Ile Arg 
            340                 345                 350         


Phe His Val Asn Met Gly Lys Leu Arg Tyr Leu Phe Asn Ala Ala Lys 
        355                 360                 365             


Asn Cys Ile Asp Gly Gln Thr Arg Val Arg Val Ile Glu His Gln Leu 
    370                 375                 380                 


Asn Gly Tyr Gly Arg Ile Asp Glu Ile Glu Ala Glu Arg Lys Ser Glu 
385                 390                 395                 400 


Asp Gly Lys Phe Ala Asn Ser Gly Ile Ser Ile Arg Asp Phe Glu Asn 
                405                 410                 415     


Val Arg Arg Asp Asp Gly Asn Pro Glu Asn Tyr Pro Tyr Val Val Asp 
            420                 425                 430         


Thr Tyr Ser His Tyr Ile Leu Glu Asn Asn Lys Val Glu Met Gln Phe 
        435                 440                 445             


Thr Asp Ser Cys Ile Leu Pro Phe Ile Glu Glu Tyr Gly Gly Lys Trp 
    450                 455                 460                 


Tyr Val Ala Lys Asp Val Pro Ala Cys Arg Ile Ser Thr Leu Glu Leu 
465                 470                 475                 480 


Pro Ala Leu Ala Phe His Met Leu Leu Leu Gly Ser Lys Lys Thr Glu 
                485                 490                 495     


Glu Arg Ile Lys Glu Val Tyr Gly Lys Tyr Met Lys Leu Phe Glu Ala 
            500                 505                 510         


Met Ser Asn Asp Ala Val Thr Lys Glu Asn Ile Glu Ser Phe Gly Ile 
        515                 520                 525             


Ala Leu Trp Asn Leu Pro Gln Lys Ala Ile Asp Ala Ile Asn Gly Cys 
    530                 535                 540                 


Ala His Ala Lys Asn Val Asn Ala Phe Ile Lys Asn Thr Val Glu Glu 
545                 550                 555                 560 


Met Leu Ala Asp Thr Glu Lys Arg Leu Glu Arg Leu Lys Glu Asp Arg 
                565                 570                 575     


Lys Gly Ile Ser Ser His Asp Asn Lys Met Gly Lys Pro Asn Phe Arg 
            580                 585                 590         


Gln Ile Ser Thr Gly Arg Leu Ala Asp Phe Leu Ala Lys Asp Ile Val 
        595                 600                 605             


Lys Leu Gln Pro Ala Thr Thr Glu Asp Gly Ser Asp Lys Met Thr Gly 
    610                 615                 620                 


Leu Asn Tyr Arg Val Met Gln Ala Ala Ile Ala Thr Tyr Asn Ser Asn 
625                 630                 635                 640 


Gly Asn Pro Glu Ala Glu Gln Gln Phe Arg Gly Met Phe Glu Lys Ala 
                645                 650                 655     


Arg Leu Ile Gly Lys Ser Pro Asn Ala His Pro Phe Leu Tyr Lys Val 
            660                 665                 670         


Phe Ala Ser Ala Leu Pro Lys Asn Thr Ile Glu Phe Tyr Asp Lys Tyr 
        675                 680                 685             


Leu Arg Glu Arg Lys Arg Tyr Leu Ser Asn Leu Thr Lys Asp Ile Glu 
    690                 695                 700                 


Ser Gly Lys Thr Ala Ser Val Pro Phe Val Asn Arg Asn Gln Asn Lys 
705                 710                 715                 720 


Trp Lys Lys Pro Asn Gln Glu Tyr Leu Gly Gln Thr Tyr Gly Asn Ser 
                725                 730                 735     


Gln Asn Leu Ala Ile Glu Leu Pro Arg Gln Met Phe Asp Ala Asp Ile 
            740                 745                 750         


Lys Ala Phe Leu Lys Gly Leu Pro Glu Met Lys Asp Val Asp Phe Asp 
        755                 760                 765             


Asn Ala Asn Val Thr Phe Leu Ile Gly Glu Tyr Met Lys Arg Val Leu 
    770                 775                 780                 


Ala Asp Asp Phe Gln Asn Phe Tyr Ala Trp Lys Arg Asn Tyr Arg Tyr 
785                 790                 795                 800 


Met Asp Met Leu Met Gly Glu Thr Asp Ser Lys Asp Gly Leu Arg His 
                805                 810                 815     


Met Phe Thr Ser Val Glu Glu Arg Glu Lys Leu Trp Arg Glu Arg Glu 
            820                 825                 830         


Gly Arg Thr Ser Ser Tyr Arg Lys Trp Ala Ala Arg Lys Asn Gln Gly 
        835                 840                 845             


Cys Gly Tyr Ser Lys Arg Leu Pro Asp Asn Val Leu Asp Glu Ile Leu 
    850                 855                 860                 


Ala Lys Arg Leu Ser Gly Ser Arg Asn Asp Tyr Gln Lys Cys Glu Lys 
865                 870                 875                 880 


Ala Ile Arg Arg Gln Lys Val Gln Asp Ala Met Leu Phe Met Leu Ala 
                885                 890                 895     


Lys Lys Ala Phe Thr Gln His Ala Asp Phe Glu Gly Lys Asp Phe Lys 
            900                 905                 910         


Leu Lys Asn Ile Met Pro Asp Ala Asp Lys Gly Ile Leu Ser Glu Thr 
        915                 920                 925             


Met Pro Met Thr Phe Thr Phe Glu Lys Gly Gly Lys Gln Tyr Thr Ile 
    930                 935                 940                 


Glu Ser Gly Gly Met Lys Leu Lys Asn Tyr Gly Asp Phe His Ala Leu 
945                 950                 955                 960 


Ala Asn Asp Arg Arg Ile Gly Cys Leu Met Lys Leu Ile Gly Thr Asn 
                965                 970                 975     


Thr Ala Gln Lys Glu Asp Leu Ile Ser Glu Phe Asn Lys Tyr Asp Gln 
            980                 985                 990         


Cys Arg Pro Gln Val Val Lys Leu  Val Leu Asp Leu Glu  Lys Trp Ala 
        995                 1000                 1005             


Phe Ala  Lys Tyr Pro Glu Leu  Gly Ala Ser Glu Glu  Met Ser Tyr 
    1010                 1015                 1020             


Val Ser  Phe Asp Lys Ile Leu  Asn Lys Leu Thr Gln  His Arg Asn 
    1025                 1030                 1035             


Leu Gly  Asn Arg Gln Ser Asn  Ile Leu Arg Lys Ile  Arg Asn Ala 
    1040                 1045                 1050             


Phe Asp  His Asn Ser Tyr Pro  Glu Ser Gly Ile Val  Glu Ile Thr 
    1055                 1060                 1065             


Thr Leu  Pro Glu Ile Ala Gln  Asn Met Lys Asp Met  Phe Gly Arg 
    1070                 1075                 1080             


Tyr Ala  Ile Val Lys 
    1085             


<210>  1677
<211>  1158
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1677

Met Lys Asn Gln Asn Ser Leu Pro Ser Asn Pro Thr Asp Ile Leu Glu 
1               5                   10                  15      


Asp Lys Pro Phe Trp Ala Ala Phe Phe Asn Leu Ala Arg His Asn Val 
            20                  25                  30          


Tyr Leu Thr Val Asn His Ile Asn Lys Leu Ile Asp Leu Glu Lys Leu 
        35                  40                  45              


Tyr Asp Glu Asp Lys His Glu Glu Ile Phe Glu Arg Glu Asp Ile Leu 
    50                  55                  60                  


Asn Ile Ser Asp Asp Val Met Asn Asp Val Asn Ser Asn Gly Lys Lys 
65                  70                  75                  80  


Arg Lys Leu Asp Ile Lys Lys Ile Trp Asp Asp Leu Asp Thr Asp Leu 
                85                  90                  95      


Thr Arg Lys Tyr Leu Leu Arg Glu Leu Ile Leu Lys His Phe Pro Phe 
            100                 105                 110         


Ile Gln Pro Ala Ile Ile Gly Ala Gln Thr Lys Glu Arg Thr Thr Ile 
        115                 120                 125             


Asp Lys Asp Lys Arg Asn Thr Ser Thr Ser Asn Asp Ser Leu Lys Gln 
    130                 135                 140                 


Thr Gly Glu Gly Asp Ile Asn Asp Pro Leu Ser Leu Ser Asn Val Lys 
145                 150                 155                 160 


Ser Met Phe Phe Ser Leu Leu Gln Met Leu Glu Gln Leu Arg Asn Tyr 
                165                 170                 175     


Tyr Ser His Val Lys His Ser Lys Ser Ala Thr Met Pro Asn Phe Asp 
            180                 185                 190         


Glu Asp Leu Leu Asn Trp Met Arg Tyr Ile Phe Ile Asp Ser Val Asn 
        195                 200                 205             


Lys Val Lys Glu Asp Tyr Ser Ser Asn Ser Val Ile Asp Pro Asn Thr 
    210                 215                 220                 


Cys Phe Ser His Leu Ile Tyr Lys Asp Lys Gln Gly Lys Ile Lys Pro 
225                 230                 235                 240 


Cys Arg Tyr Pro Phe Thr Ser Lys Asp Gly Ser Ile Asn Ala Phe Gly 
                245                 250                 255     


Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys Gln Asp Ser Ile Trp 
            260                 265                 270         


Met Gln Lys Lys Ile Pro Gly Phe Lys Lys Ala Ser Glu Asn Tyr Met 
        275                 280                 285             


Lys Met Thr Asn Glu Val Phe Cys Arg Asn His Ile Leu Leu Pro Lys 
    290                 295                 300                 


Ile Arg Leu Glu Thr Val Tyr Asp Lys Asp Trp Met Leu Leu Asp Met 
305                 310                 315                 320 


Leu Asn Glu Val Val Arg Cys Pro Leu Ser Leu Tyr Lys Arg Leu Thr 
                325                 330                 335     


Pro Ala Asp Gln Asn Lys Phe Lys Val Pro Glu Lys Ser Ser Asp Asn 
            340                 345                 350         


Ala Asn Arg Gln Glu Asp Asp Asn Pro Phe Ser Arg Ile Leu Val Arg 
        355                 360                 365             


His Gln Asn Arg Phe Pro Tyr Phe Val Leu Arg Phe Phe Asp Leu Asn 
    370                 375                 380                 


Glu Val Phe Thr Thr Leu Arg Phe Gln Ile Asn Leu Gly Cys Tyr His 
385                 390                 395                 400 


Phe Ala Ile Cys Lys Lys Gln Ile Gly Asp Lys Lys Glu Val His His 
                405                 410                 415     


Leu Thr Arg Thr Leu Tyr Gly Phe Ser Arg Leu Gln Asn Phe Thr Gln 
            420                 425                 430         


Asn Thr Arg Pro Glu Glu Trp Asn Thr Leu Val Lys Thr Thr Glu Pro 
        435                 440                 445             


Ser Ser Gly Asn Asp Gly Lys Thr Val Gln Gly Val Pro Leu Pro Tyr 
    450                 455                 460                 


Ile Ser Tyr Thr Ile Pro His Tyr Gln Ile Glu Asn Glu Lys Ile Gly 
465                 470                 475                 480 


Ile Lys Ile Phe Asp Gly Asp Thr Ala Val Asp Thr Asp Ile Trp Pro 
                485                 490                 495     


Ser Val Ser Thr Glu Lys Gln Leu Asn Lys Pro Asp Lys Tyr Thr Leu 
            500                 505                 510         


Thr Pro Gly Phe Lys Ala Asp Val Phe Leu Ser Val His Glu Leu Leu 
        515                 520                 525             


Pro Met Met Phe Tyr Tyr Gln Leu Leu Leu Cys Glu Gly Met Leu Lys 
    530                 535                 540                 


Thr Asp Ala Gly Asn Ala Val Glu Lys Val Leu Ile Asp Thr Arg Asn 
545                 550                 555                 560 


Ala Ile Phe Asn Leu Tyr Asp Ala Phe Val Gln Glu Lys Ile Asn Thr 
                565                 570                 575     


Ile Thr Asp Leu Glu Asn Tyr Leu Gln Asp Lys Pro Ile Leu Ile Gly 
            580                 585                 590         


His Leu Pro Lys Gln Met Ile Asp Leu Leu Lys Gly His Gln Arg Asp 
        595                 600                 605             


Met Leu Lys Ala Ala Glu Gln Lys Lys Ala Met Leu Ile Lys Asp Thr 
    610                 615                 620                 


Glu Arg Arg Leu Glu Arg Leu Asn Lys Gln Pro Glu Gln Lys Pro Asn 
625                 630                 635                 640 


Val Ala Ala Lys Asn Ile Gly Ala Leu Leu Arg Asn Gly Gln Ile Ala 
                645                 650                 655     


Asp Trp Leu Val Lys Asp Met Met Arg Phe Gln Pro Val Lys Arg Asp 
            660                 665                 670         


Lys Glu Gly Asn Pro Ile Asn Cys Ser Lys Ala Asn Ser Thr Glu Tyr 
        675                 680                 685             


Gln Met Leu Gln Arg Ala Phe Ala Phe Tyr Ala Thr Asp Ser Cys Arg 
    690                 695                 700                 


Leu Pro Arg Tyr Phe Glu Gln Leu His Leu Ile Asn Cys Asp Asn Ser 
705                 710                 715                 720 


His Leu Phe Leu Ser Arg Phe Glu Tyr Asp Lys Gln Pro Asn Leu Ile 
                725                 730                 735     


Ala Phe Tyr Ala Ala Tyr Leu Lys Ala Lys Leu Asp Phe Leu Asn Glu 
            740                 745                 750         


Leu Gln Pro Gln Asn Trp Val Ser Asp Asn Tyr Phe Leu Leu Leu Arg 
        755                 760                 765             


Ala Pro Lys Asn Asn Arg Gln Lys Leu Ala Glu Gly Trp Lys Asn Gly 
    770                 775                 780                 


Phe Asn Leu Pro Arg Gly Leu Phe Thr Glu Lys Ile Lys Thr Trp Phe 
785                 790                 795                 800 


Asn Glu His Lys Thr Ile Val Asp Ile Ser Asp Cys Asp Ile Phe Lys 
                805                 810                 815     


Asn Arg Val Gly Gln Val Ala Arg Leu Ile Pro Val Phe Phe Asp Lys 
            820                 825                 830         


Lys Phe Lys Asp His Ser Gln Pro Phe Tyr Arg Tyr Asn Phe Asn Val 
        835                 840                 845             


Gly Asn Val Ser Lys Pro Thr Glu Ala Lys Tyr Leu Ser Lys Glu Lys 
    850                 855                 860                 


Arg Glu Glu Leu Phe Lys Ser Tyr Gln Asn Lys Phe Lys Asn Asn Ile 
865                 870                 875                 880 


Pro Ala Glu Lys Thr Lys Glu Tyr Arg Glu Tyr Lys Asn Phe Ser Leu 
                885                 890                 895     


Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys Asn Gln Asp Ile 
            900                 905                 910         


Leu Thr Trp Leu Met Cys Lys Asn Leu Phe Asp Glu Lys Ile Glu Gln 
        915                 920                 925             


Gly Ile Asp Ile Pro Tyr Ile Lys Leu Asp Ser Leu Gln Thr Asn Thr 
    930                 935                 940                 


Ser Thr Lys Gly Ser Leu Asn Ala Leu Ala Gln Val Leu Pro Met Val 
945                 950                 955                 960 


Leu Ala Ile Tyr Ile Gly Asn Ser Glu Ser Asn Asn Gly Thr Gly Ala 
                965                 970                 975     


Asn Glu Glu Glu Asn Lys Gly Pro Met Val Tyr Ile Lys Glu Glu Gly 
            980                 985                 990         


Thr Lys Leu Leu Lys Trp Gly Asn  Phe Lys Thr Leu Leu  Ala Asp Arg 
        995                 1000                 1005             


Arg Ile  Lys Gly Leu Phe Ser  Tyr Ile Glu His Asp  Asp Ile Asp 
    1010                 1015                 1020             


Leu Lys  Gln His Pro Leu Thr  Lys Arg Arg Val Asp  Leu Glu Leu 
    1025                 1030                 1035             


Asp Leu  Tyr Gln Thr Cys Arg  Ile Asp Ile Phe Gln  Gln Thr Leu 
    1040                 1045                 1050             


Gly Leu  Glu Ala Gln Leu Leu  Asn Lys Tyr Ser Asp  Leu Asn Thr 
    1055                 1060                 1065             


Asp Asn  Phe Tyr Gln Met Leu  Ile Gly Trp Arg Lys  Lys Glu Gly 
    1070                 1075                 1080             


Ile Pro  Arg Asp Ile Lys Glu  Asp Thr Asp Phe Leu  Lys Asp Val 
    1085                 1090                 1095             


Arg Asn  Ala Phe Ser His Asn  Gln Tyr Pro Asp Ser  Lys Lys Ile 
    1100                 1105                 1110             


Ala Phe  Ser Arg Ile Arg Lys  Phe Asn Pro Lys Lys  Thr Ile Leu 
    1115                 1120                 1125             


Asn Glu  Lys Lys Gly Leu Gly  Ile Ala Lys Gln Met  Tyr Glu Glu 
    1130                 1135                 1140             


Val Glu  Lys Val Val Asn Arg  Ile Lys Gly Ile Glu  Leu Phe Asp 
    1145                 1150                 1155             


<210>  1678
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1678

Leu Gln Lys Gln Asp Lys Leu Phe Val Asp Arg Lys Lys Asn Ala Ile 
1               5                   10                  15      


Phe Ala Phe Pro Lys Tyr Ile Thr Ile Met Glu Asn Lys Glu Lys Pro 
            20                  25                  30          


Glu Leu Ile Tyr Tyr Glu Leu Thr Asp Lys His Phe Trp Ala Ala Phe 
        35                  40                  45              


Leu Asn Leu Ala Arg His Asn Val Tyr Thr Thr Val Asn His Ile Asn 
    50                  55                  60                  


Lys Leu Leu Glu Ile Ala Glu Leu Lys Asn Asp Glu Asp Val Leu Asn 
65                  70                  75                  80  


Ile Lys Asp Ser Trp Asn Lys Gln Ala Glu Lys Leu Asp Lys Lys Val 
                85                  90                  95      


Arg Leu Arg Asp Leu Ile Met Lys Tyr Phe Pro Phe Leu Glu Ala Ala 
            100                 105                 110         


Ala Tyr Glu Ile Thr Asn Ser Lys Ser Pro Asn Asn Lys Glu Gln Arg 
        115                 120                 125             


Glu Lys Glu Gln Ser Glu Ala Leu Ser Leu Asn Asn Leu Lys Asn Val 
    130                 135                 140                 


Leu Phe Ile Phe Leu Glu Lys Leu Gln Val Leu Arg Asn Tyr Tyr Ser 
145                 150                 155                 160 


His Tyr Lys Tyr Ser Glu Glu Phe Pro Lys Pro Ile Phe Glu Thr Ser 
                165                 170                 175     


Leu Leu Lys Asn Met Tyr Lys Val Phe Asp Ala Asn Val Arg Leu Val 
            180                 185                 190         


Lys Arg Asp Tyr Met His His Glu Asn Ile Asp Met Gln Arg Asp Phe 
        195                 200                 205             


Thr His Leu Asn Arg Lys Lys Gln Val Gly Arg Thr Lys Asn Ile Ile 
    210                 215                 220                 


Asp Ser Pro Asn Phe His Tyr His Phe Ala Asp Lys Glu Gly Asn Met 
225                 230                 235                 240 


Thr Ile Ala Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Asp Lys Lys 
                245                 250                 255     


Asp Ala Ile Trp Met Gln Lys Lys Leu Lys Gly Phe Lys Asp Gly Arg 
            260                 265                 270         


Asn Leu Arg Glu Gln Met Thr Asn Glu Val Phe Cys Arg Ser Arg Ile 
        275                 280                 285             


Ser Leu Pro Lys Leu Lys Met Glu Thr Val Gln Thr Arg Glu Trp Met 
    290                 295                 300                 


Gln Leu Asp Met Leu Asn Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr 
305                 310                 315                 320 


Glu Arg Leu Arg Glu Glu Asp Arg Glu Ser Phe Lys Val Pro Phe Asp 
                325                 330                 335     


Ile Phe Ser Asp Asp Tyr Asn Ala Glu Glu Glu Pro Phe Lys Asn Thr 
            340                 345                 350         


Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe 
        355                 360                 365             


Asp Leu Asn Glu Ile Phe Glu Gln Leu Arg Phe Gln Ile Asp Leu Gly 
    370                 375                 380                 


Thr Tyr His Phe Ser Ile Tyr Asn Lys Leu Ile Gly Asp Glu Asp Glu 
385                 390                 395                 400 


Val Arg His Leu Thr His His Leu Tyr Gly Phe Ala Arg Ile Gln Asp 
                405                 410                 415     


Phe Ala Pro Gln Asn Gln Pro Glu Glu Trp Arg Lys Leu Val Lys Asp 
            420                 425                 430         


Leu Asp His Phe Glu Thr Ser Gln Lys Pro Tyr Ile Ser Lys Thr Thr 
        435                 440                 445             


Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Lys Phe Cys Ser 
    450                 455                 460                 


Ala His Asn Asn Leu Phe Pro Ser Leu Gln Thr Asp Lys Thr Cys Asn 
465                 470                 475                 480 


Gly Arg Ser Lys Phe Asn Leu Gly Thr Gln Phe Thr Ala Glu Ala Phe 
                485                 490                 495     


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu 
            500                 505                 510         


Thr Lys Asp Tyr Ser Arg Lys Glu Ser Ala Asp Lys Val Glu Gly Ile 
        515                 520                 525             


Ile Arg Lys Glu Ile Ser Asn Ile Tyr Ala Ile Tyr Asp Ala Phe Ala 
    530                 535                 540                 


Asn Gly Glu Ile Asn Ser Ile Ala Asp Leu Thr Arg Arg Leu Gln Asn 
545                 550                 555                 560 


Thr Asn Ile Leu Gln Gly His Leu Pro Lys Gln Met Ile Ser Ile Leu 
                565                 570                 575     


Glu Gly Arg Gln Lys Asp Met Glu Lys Lys Ala Glu Arg Lys Ile Gly 
            580                 585                 590         


Glu Met Ile Asp Asp Thr Gln Arg Arg Leu Asp Ser Leu Cys Lys Gln 
        595                 600                 605             


Thr Asn Gln Lys Ile Arg Ile Gly Lys Arg Asn Ala Gly Leu Leu Lys 
    610                 615                 620                 


Ser Gly Lys Ile Ala Asp Trp Leu Val Asn Asp Met Met Arg Phe Gln 
625                 630                 635                 640 


Pro Val Gln Lys Asp Gln Asn Asn Ile Pro Ile Asn Asn Ser Lys Ala 
                645                 650                 655     


Asn Ser Thr Glu Tyr Arg Met Leu Gln His Ala Leu Ala Leu Phe Gly 
            660                 665                 670         


Ser Glu Ser Ser Arg Leu Lys Ala Tyr Phe Arg Gln Met Asn Leu Val 
        675                 680                 685             


Gly Asn Ala Asn Pro His Pro Phe Leu Ala Glu Thr Gln Trp Glu His 
    690                 695                 700                 


Gln Thr Asn Ile Leu Ser Phe Tyr Arg Asn Tyr Leu Glu Ala Arg Lys 
705                 710                 715                 720 


Lys Tyr Leu Lys Gly Leu Lys Pro Gln Asn Arg Lys Gln Tyr Gln His 
                725                 730                 735     


Phe Leu Ile Leu Lys Val Gln Lys Thr Asn Arg Asn Thr Leu Val Thr 
            740                 745                 750         


Gly Trp Lys Asn Ser Phe Asn Leu Pro Arg Gly Ile Phe Thr Gln Pro 
        755                 760                 765             


Ile Arg Glu Trp Phe Glu Lys His Asn Asn Ser Lys Arg Ile Tyr Asp 
    770                 775                 780                 


Gln Ile Leu Ser Phe Asp Arg Val Gly Phe Val Ala Lys Ala Ile Pro 
785                 790                 795                 800 


Leu Tyr Phe Ala Glu Glu Tyr Lys Asp Asn Val Gln Pro Phe Tyr Asp 
                805                 810                 815     


Tyr Pro Phe Asn Ile Gly Asn Lys Leu Lys Pro Gln Lys Gly Gln Phe 
            820                 825                 830         


Leu Asp Lys Lys Glu Arg Val Glu Leu Trp Gln Lys Asn Lys Glu Leu 
        835                 840                 845             


Phe Lys Asn Tyr Pro Ser Glu Lys Lys Lys Thr Asp Leu Ala Tyr Leu 
    850                 855                 860                 


Asp Phe Leu Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys 
865                 870                 875                 880 


Asn Gln Asp Ile Val Thr Trp Leu Met Phe Lys Glu Leu Phe Lys Thr 
                885                 890                 895     


Thr Thr Val Glu Gly Leu Lys Ile Gly Glu Ile His Leu Arg Asp Ile 
            900                 905                 910         


Asp Thr Asn Thr Ala Asn Glu Glu Ser Asn Asn Ile Leu Asn Arg Ile 
        915                 920                 925             


Met Pro Met Lys Leu Pro Val Lys Thr Tyr Glu Thr Asp Asn Lys Gly 
    930                 935                 940                 


Asn Ile Leu Lys Glu Arg Pro Leu Ala Thr Phe Tyr Ile Glu Glu Thr 
945                 950                 955                 960 


Glu Thr Lys Val Leu Lys Gln Gly Asn Phe Lys Val Leu Ala Lys Asp 
                965                 970                 975     


Arg Arg Leu Asn Gly Leu Leu Ser Phe Ala Glu Thr Thr Asp Ile Asp 
            980                 985                 990         


Leu Glu Lys Asn Pro Ile Thr Lys  Leu Ser Val Asp His  Glu Leu Ile 
        995                 1000                 1005             


Lys Tyr  Gln Thr Thr Arg Ile  Ser Ile Phe Glu Met  Thr Leu Gly 
    1010                 1015                 1020             


Leu Glu  Lys Lys Leu Ile Asp  Lys Tyr Ser Thr Leu  Pro Thr Asp 
    1025                 1030                 1035             


Ser Phe  Arg Asn Met Leu Glu  Arg Trp Leu Gln Cys  Lys Ala Asn 
    1040                 1045                 1050             


Arg Pro  Glu Leu Lys Asn Tyr  Val Asn Ser Leu Ile  Ala Val Arg 
    1055                 1060                 1065             


Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met Tyr Asp  Ala Thr Leu 
    1070                 1075                 1080             


Phe Ala  Glu Val Lys Lys Phe  Thr Leu Phe Pro Ser  Val Asp Thr 
    1085                 1090                 1095             


Lys Lys  Ile Glu Leu Asn Ile  Ala Pro Gln Leu Leu  Glu Ile Val 
    1100                 1105                 1110             


Gly Lys  Ala Ile Lys Glu Ile  Glu Lys Ser Glu Asn  Lys Asn 
    1115                 1120                 1125         


<210>  1679
<211>  1105
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1679

Met Asn Arg Pro Asn Leu Val Glu Lys Asn Lys His Ile Phe Gly Thr 
1               5                   10                  15      


Tyr Ala Val Met Ala Met Asn Asn Val Gln Met Val Phe Glu His Ile 
            20                  25                  30          


Arg Lys Ile Ala Gly Leu Pro Asp Ile Thr Asp Asp Thr Tyr Arg Pro 
        35                  40                  45              


Glu Asp Leu Trp Thr His Pro Val Met Ala Val Leu Leu Lys Ala Lys 
    50                  55                  60                  


Asn Gly Glu Pro Thr Asp Asn Ala Thr Thr Gln Leu Ile Val Glu Lys 
65                  70                  75                  80  


Met Leu Asp Gln Phe Pro Phe Leu Arg Ile Met Gly Glu Asn Gln Arg 
                85                  90                  95      


Ala Phe Arg Ser Lys Lys Asp Glu Lys Lys Gly Ser Ala Glu Lys Met 
            100                 105                 110         


Leu Gly Ala Val Asp Ile Tyr Asp Val Met Asn Ser Met Leu Arg Val 
        115                 120                 125             


Val Lys Ala Tyr Arg Asp Ala Thr Glu His Leu Met Phe Asp Ser Ser 
    130                 135                 140                 


Leu Trp Asn Asp Gly Ser Pro Phe Leu Lys Tyr Asn Glu Gln Val Met 
145                 150                 155                 160 


Ala Gly Val Ile Glu Asn Tyr Tyr Gly Val Ala Leu Arg Asn Val Lys 
                165                 170                 175     


Glu Arg Phe Gly Tyr Thr Thr Asp Asp Leu Arg Phe Ile Gln Asp His 
            180                 185                 190         


Arg Met Lys Asp Val Arg Val Pro Gly Glu Arg Phe Leu Arg Lys Thr 
        195                 200                 205             


Tyr Asp Leu Asp Phe Phe Leu Ser Ile Lys Ala Thr Asn Gly Asp Arg 
    210                 215                 220                 


Thr Gly Lys Leu His Leu Ser Gly Val Gly Val Thr Leu Leu Ile Cys 
225                 230                 235                 240 


Leu Leu Leu His Lys Gln Tyr Val Thr Ile Met Leu Ser Lys Leu Gln 
                245                 250                 255     


Gly Ile Tyr Gly Lys Tyr Arg Ala Gly Ser Lys Glu Arg Gln Ile Ile 
            260                 265                 270         


Leu Arg Ser Phe Ala Ile Asn Gly Ile Val Leu Pro Lys Glu Arg Ile 
        275                 280                 285             


Arg Ser Asp Lys Ser Glu Met Ser Val Ala Leu Asp Met Ile Asn Glu 
    290                 295                 300                 


Leu Lys Arg Cys Pro Arg Glu Leu Phe Asp Val Leu Ser Val Asp Asp 
305                 310                 315                 320 


Gln Glu Arg Phe Arg Leu Gln Ser Ala Asp Met Glu Asp Val Leu Gln 
                325                 330                 335     


Met Arg His Ser Asp Arg Phe Ala Gln Leu Val Met Gln Tyr Phe Asp 
            340                 345                 350         


Tyr Gly Glu Leu Leu Pro Thr Ile Arg Phe Gln Val Asn Met Gly Lys 
        355                 360                 365             


Leu Arg Tyr Leu Phe Asn Ala Ala Lys Asn Cys Ile Asp Gly Ala Thr 
    370                 375                 380                 


Arg Val Arg Val Leu Glu His Arg Leu Asn Ala Tyr Gly Arg Val Gln 
385                 390                 395                 400 


Glu Met Glu Ala Lys Arg Lys Asn Ala Thr Gly Ala Phe Ile Gly Thr 
                405                 410                 415     


Asn Ile Asp Val Arg Glu Phe Asp Glu Val Arg Arg Asp Asp Ala Asn 
            420                 425                 430         


Pro Ala Asn Tyr Pro Tyr Val Val Asp Thr Tyr Thr His Tyr Ile Ile 
        435                 440                 445             


Glu Asn Asn Lys Ile Asn Phe Thr Phe Gly Glu Gln Leu Pro Ala Val 
    450                 455                 460                 


Glu Asn Asp Gly Gly Lys Trp Tyr Val Asn Asn Ile Ile Ala His Cys 
465                 470                 475                 480 


Ser Met Ser Val Leu Glu Leu Pro Ala Met Val Phe His Ser His Leu 
                485                 490                 495     


Tyr Gly Ala Ala Lys Thr Glu Ala Leu Ile Arg Arg Thr Trp Asp Asn 
            500                 505                 510         


Tyr Asn Arg Leu Phe Ala Asp Met Arg Asp Gly Lys Leu Thr Lys Ala 
        515                 520                 525             


Asn Leu Gly Thr Tyr Gly Ile Ala Glu Ala Asp Met Pro Ala Lys Val 
    530                 535                 540                 


Leu Glu Ala Val Asn Gly Gly Gly Lys Ser His Gly Tyr Trp Ala His 
545                 550                 555                 560 


Val Arg Lys Glu Ile Asp Glu Met Leu Ala Asp Thr Glu Arg Arg Ile 
                565                 570                 575     


Thr Arg Leu Lys Asp Asp Lys Arg Ala Val Asp Ser Lys Met Asn Lys 
            580                 585                 590         


Met Gly Lys Arg Gly Phe Val Arg Ile Met Pro Gly Arg Leu Ala Asp 
        595                 600                 605             


Trp Leu Ala Glu Asp Ile Val Arg Leu Gln Arg Ser Ser Leu Thr Gly 
    610                 615                 620                 


Thr Glu Tyr Gly Thr Asp Arg Ile Thr Gly Leu Asn Tyr Arg Thr Leu 
625                 630                 635                 640 


Gln Ala Ala Ile Ala Thr Phe Asn Ser Asn His Asp Ile Val Asp Gly 
                645                 650                 655     


Glu Ser Leu Lys Ala Leu Thr Asp Met Phe Ala Lys Ala Gly Leu Thr 
            660                 665                 670         


Ile Arg Asn Gly Lys Thr Ala His Pro Phe Leu Phe Phe Val Leu Gly 
        675                 680                 685             


Ser Lys Pro Arg Asn Thr Ile Asp Leu Tyr Glu Ser Tyr Leu Lys Gln 
    690                 695                 700                 


Arg Lys Thr Tyr Leu Ser Asn Leu Leu Glu Lys Ile Ser Asn Asp Thr 
705                 710                 715                 720 


Leu Ala Lys Thr Asp Ile Thr Phe Val Asn Pro Glu Ser Ala Arg Phe 
                725                 730                 735     


Ser Gln Arg Asn Ala Glu Tyr Tyr Arg Asp Thr Ala Ala Asp Tyr Leu 
            740                 745                 750         


Asp Tyr His Ala Ile Glu Leu Pro Arg Gln Met Phe Glu Pro Glu Ile 
        755                 760                 765             


Lys Ala Met Leu Lys Lys Leu Pro Glu Met Lys Asp Val Asp Phe Gln 
    770                 775                 780                 


Asn Ala Asn Val Thr Tyr Leu Ile Ala Glu Tyr Leu Lys Arg Phe Cys 
785                 790                 795                 800 


Asn Asp Asp Phe Gln Pro Phe Tyr Asn Leu Lys Arg Asn Tyr Arg Tyr 
                805                 810                 815     


Ile Asp Met Leu Val Tyr Asp Thr Asp Ser Arg Gly Lys Leu Gln Pro 
            820                 825                 830         


Gln Tyr Thr Thr Val Ala Arg Arg Glu Glu Leu Trp Ala Asp Arg Asn 
        835                 840                 845             


Asp Lys Val Lys Arg Tyr Arg Gln Ala Lys Val Asn Ala Leu Tyr Leu 
    850                 855                 860                 


Asp Pro Lys Asn Arg Leu Ser Lys Thr Glu Ile Glu Ala Arg Val Asp 
865                 870                 875                 880 


Lys Ser Ile Ala Asn Ala Arg Asn Glu Tyr Thr Ser Thr Glu Lys Val 
                885                 890                 895     


Ile Arg Arg Tyr Lys Val Gln Asp Ala Leu Leu Phe Leu Leu Ala Cys 
            900                 905                 910         


Asp Thr Ile Thr Gln Asn Val Gln Leu Glu Gly Lys Arg Phe Lys Leu 
        915                 920                 925             


Asn Ala Val Glu Pro Ser Ala Glu Thr Gly Ile Leu Ser Glu Val Met 
    930                 935                 940                 


Pro Ile Asn Phe Glu Phe Thr Phe Glu Gly Lys Arg Tyr Thr Leu His 
945                 950                 955                 960 


Ala Asp Gly Met Lys Ile Lys Asn Tyr Gly Asp Phe Phe Arg Leu Ile 
                965                 970                 975     


Asn Asp Gln Arg Leu Pro Ser Leu Leu Asn Ile Val Gly Thr Thr Gln 
            980                 985                 990         


Leu Glu Lys Lys Gln Met Asp Glu  Glu Leu Ser Asn Tyr  Asp Asn Cys 
        995                 1000                 1005             


Arg Pro  Glu Met Val Lys Met  Ile Leu Gly Leu Glu  Lys Glu Ile 
    1010                 1015                 1020             


Tyr Thr  Arg Phe Pro Glu Lys  Lys Asn Leu Val Tyr  Glu Ile Glu 
    1025                 1030                 1035             


Arg Phe  Asn Phe Ser Lys Leu  Met Ala Glu Met Val  Arg Glu Gly 
    1040                 1045                 1050             


Met Phe  Ser His Asp Asp Arg  Asn Thr Ile Asn Leu  Ile Arg Asn 
    1055                 1060                 1065             


Ala Phe  Ser His Asn Arg Tyr  Pro Glu Lys Val Val  Ile Ser Gly 
    1070                 1075                 1080             


Leu Cys  Ile Pro Glu Val Ala  Lys Ser Tyr Glu Ala  Lys Met Ser 
    1085                 1090                 1095             


Gln Met  Ala His Leu Pro Glu  
    1100                 1105 


<210>  1680
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1680

Met Asn Asn Thr Met Glu Ala Glu Gly Lys Asn Glu Arg Thr Leu Gln 
1               5                   10                  15      


Asp Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Val Ala Asp Lys Leu Ser Ile Ala Leu 
        35                  40                  45              


Leu Lys Asn Glu Glu Asp Ile Ser Asn Ser Phe Leu Cys Asn Pro Asn 
    50                  55                  60                  


Gln Lys Leu Asn Trp Ser Lys Ala Tyr Ala Met Thr Met Arg Phe Met 
65                  70                  75                  80  


Pro Leu Leu Lys Val Phe Asp Thr Glu Arg Leu Pro Glu His Arg Thr 
                85                  90                  95      


Ser Lys Lys Asp Lys Glu Lys Gly Lys Glu Phe Gly Lys Met Cys Asp 
            100                 105                 110         


Ser Leu Lys Ile Val Phe Arg Glu Leu Asn Gln Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Ala Ser Thr Glu Asp Asn Phe Thr Arg Lys Ile Glu Ile 
    130                 135                 140                 


Ser Asp Glu Leu Ala Glu Phe Leu Thr Cys Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Glu Tyr Thr Lys Gln Arg Phe Ala Asp Thr Tyr Gln Asp Glu Asp Phe 
                165                 170                 175     


Lys Leu Ala Glu Arg Met Gln Met Val Gln Gly Asn Ile Ile Thr Ser 
            180                 185                 190         


Glu Gly Ile Val Phe Leu Thr Ser Leu Phe Leu Glu Arg Glu His Ala 
        195                 200                 205             


Phe Leu Phe Ile Gly Lys Val Lys Gly Leu Lys Gly Thr Gln Phe Lys 
    210                 215                 220                 


Gln Phe Lys Ala Thr Arg Glu Val Phe Met Ser Tyr Cys Val Asn Leu 
225                 230                 235                 240 


Pro Gln Asp Lys Leu Ile Ser Asp Asp Tyr Thr Gln Ser Leu Thr Met 
                245                 250                 255     


Asp Ile Ile Asn Glu Leu Thr Lys Cys Pro Glu Thr Leu Tyr Asn Val 
            260                 265                 270         


Leu Asp Glu Ser Ala Arg Lys Gln Phe Ile Pro Gln Leu Gly Glu Val 
        275                 280                 285             


Glu Thr Asp Asn Val Arg Gln Asn Ser Ile Asn Glu Ala Glu Ile Thr 
    290                 295                 300                 


Asp Glu Asn Asp Tyr Ala Gln Tyr Met Glu Asp Leu Thr Lys Arg Val 
305                 310                 315                 320 


Arg His Ser Asn Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Ile Asp Glu 
                325                 330                 335     


Phe Asn Leu Leu Gly Lys Phe Lys Phe Gln Leu Asp Leu Gly Lys Leu 
            340                 345                 350         


Lys Leu Asp Thr Tyr Pro Lys Ser Tyr Met Gly Glu Asp Val Asp Arg 
        355                 360                 365             


Thr Ile Thr Glu Asn Val Ser Ala Phe Gly Lys Leu Ser Asp Gln Gln 
    370                 375                 380                 


Val Lys Glu Glu Val Gln Ala Lys Val Val Lys Asp Tyr Ser Ser Val 
385                 390                 395                 400 


Gln Phe Asp Gln Phe Ala Pro His Tyr Asn Met Glu Cys Asn Lys Ile 
                405                 410                 415     


Gly Ile Ser Arg Lys Ser Glu Thr Ala Ile Val Ile Lys Pro Ser Lys 
            420                 425                 430         


Thr Asp Ala Lys Ser Ser Tyr Lys Leu Lys Gln Pro Ile Pro Glu Ala 
        435                 440                 445             


Phe Leu Ser Ile Lys Glu Leu Ser Lys Ile Val Leu Leu Glu Tyr Leu 
    450                 455                 460                 


Ser Pro Gly Glu Ser Gln Arg Leu Ile Thr Asp Phe Ile Ser Thr Asn 
465                 470                 475                 480 


Ser Asp Lys Leu Met Asn Leu Asp Phe Ile Lys Glu Val Lys Gly Lys 
                485                 490                 495     


Leu Pro Val Phe Asp Lys Pro Phe Tyr Lys Lys Val Thr Ile Lys Ser 
            500                 505                 510         


Glu Ser Tyr Thr Lys Asp Glu Leu Lys Glu Leu Glu Ala Arg Lys Lys 
        515                 520                 525             


Leu Leu Asp Gln Val Leu Val Thr Tyr Gly Leu Asn Thr Lys Gln Ile 
    530                 535                 540                 


Pro Thr Arg Ile Thr Glu Tyr Trp Leu Asn Ile Arg Asp Val Arg Asn 
545                 550                 555                 560 


Gln His Ile Ile Ser Glu Arg Ile Lys Ser Ile Arg Lys Asp Cys Thr 
                565                 570                 575     


Thr Arg Leu Lys Ala Leu Lys Lys Leu Asp Glu Thr Gly Lys Gly Asn 
            580                 585                 590         


Val Pro Lys Ile Gly Glu Met Ala Ser Phe Leu Ala Arg Asp Ile Val 
        595                 600                 605             


Ser Met Val Ile Asp Pro Val Lys Lys Lys Lys Ile Thr Ser Phe Tyr 
    610                 615                 620                 


Tyr Asp Lys Leu Gln Ala Ser Leu Ala Leu Phe Ala Asp Pro Asp Lys 
625                 630                 635                 640 


Lys Lys Glu Phe Met His Leu Val Asn Asp Glu Leu Asn Leu Leu Ser 
                645                 650                 655     


Val Gly Gly His Pro Phe Leu Lys Asn Ile Asp Phe Thr Thr Ile His 
            660                 665                 670         


Tyr Thr Arg Asp Leu Tyr Lys Lys Tyr Leu Glu Glu Lys Gly Cys Lys 
        675                 680                 685             


Ile Ile Asn Gly Lys Thr Asp Ile Ser Trp Ile Phe Lys Thr Phe Tyr 
    690                 695                 700                 


Lys Lys Glu Pro Gly Lys Asn Ser Ser Leu Pro Val Thr Lys Val Lys 
705                 710                 715                 720 


Leu Pro Leu Asp Lys Asp Gly Asn Pro Asp Ser Lys Gln Leu Pro His 
                725                 730                 735     


Ser Leu Tyr Ser Leu Gly Asn Arg Lys Thr Asp Asn Ser Ile Glu Glu 
            740                 745                 750         


Ile Thr Lys Trp Leu Ser Asn Val Lys His Gly Lys Glu Lys Thr Asp 
        755                 760                 765             


Cys Thr Lys Pro Val Asp Leu Pro Ile Asn Leu Phe Asp Ser Arg Leu 
    770                 775                 780                 


Ile Glu Leu Leu Lys Lys Glu Thr Gly Asp Thr Ser Leu Ala Pro Lys 
785                 790                 795                 800 


Leu Asn Gly Leu Phe Val Thr Trp Trp Glu Thr Arg Gly Asp Ser Thr 
                805                 810                 815     


Gln Ser Phe Tyr Asn Asp Lys Arg Asn Tyr Val Ile Tyr Asp Gln Glu 
            820                 825                 830         


Val Cys Phe Tyr Pro Asn Thr Lys Glu Leu Tyr Gln Asp Tyr Tyr Gln 
        835                 840                 845             


Ser Ala Leu Asp Arg Ala Phe Arg Leu Lys Arg Glu Glu Arg Arg Gln 
    850                 855                 860                 


Glu Arg Leu Leu Asn Arg Arg Leu Pro Glu Ile Gln Leu Lys Asp Met 
865                 870                 875                 880 


Lys Lys Ile Phe Asn Ile Thr Leu Ser Glu Thr Glu Lys Glu Ile Arg 
                885                 890                 895     


Ile Leu Gln Glu Glu Asp Arg Leu Leu Phe Leu Ile Leu Glu Lys Leu 
            900                 905                 910         


Met Gly Asn Asp Phe Ala Gly Ser Leu Tyr Leu Lys Asn Val Asn Glu 
        915                 920                 925             


Leu Leu Asn Glu Lys Val Asp Ile Arg Gln Pro Ile Lys Thr Phe Leu 
    930                 935                 940                 


Ser Phe Lys Glu Asn Gly Glu Leu Ala Ser Lys Asp Glu Arg Met Gln 
945                 950                 955                 960 


Ile Thr Lys Asn Ile Ile Ser Tyr Gly Ser Arg Lys Asn Tyr Gly Leu 
                965                 970                 975     


Leu Arg Arg Tyr Val His Asp Arg Arg Met Pro Glu Leu Phe Glu Tyr 
            980                 985                 990         


Tyr Pro Thr Asp Asp Ile Ser Phe  Glu Ala Ile Lys Gln  Glu Leu Asp 
        995                 1000                 1005             


Asp Tyr  Asn Lys Ala Lys Gln  Ile Val Phe Asp Lys  Val Phe Glu 
    1010                 1015                 1020             


Leu Glu  Arg Ala Leu Thr Lys  Arg Phe Lys Asp Glu  Val Met Ala 
    1025                 1030                 1035             


His Phe  Val Asn Arg Asp Gly  Gly Ser Arg Leu Lys  Gly Asn Ile 
    1040                 1045                 1050             


Gln His  Ser Pro Tyr Leu Asn  Leu Leu Lys Ser Lys  Gly Ile Ile 
    1055                 1060                 1065             


Ser Lys  Asp Ala His Arg Phe  Leu Lys Ala Val Arg  Asn Ala Phe 
    1070                 1075                 1080             


Ser His  Asn Gln Tyr Pro His  Lys Lys Thr Met Glu  Ile Phe Val 
    1085                 1090                 1095             


Lys Glu  Trp Asn Ala Ser Asn  Phe Ala Asn Gln Ile  Val Glu Ile 
    1100                 1105                 1110             


Tyr Lys  Gln Lys Ile Glu Glu  Ile Ile Glu Ile Ile  Lys Lys 
    1115                 1120                 1125         


<210>  1681
<211>  1057
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1681

Met Thr Ile Lys Glu Gln Ser His Phe Ala Ala Tyr Tyr Asn Met Ala 
1               5                   10                  15      


Arg His Asn Met Tyr Glu Thr Leu Cys Tyr Ile Ser Lys Ile Ser Gly 
            20                  25                  30          


Ile Gln Glu Gly Glu Asp Asn Lys Glu Ser Lys Ile Glu Asp Met Gln 
        35                  40                  45              


Leu Leu Arg Val Leu Thr Thr Lys Gly His Pro Glu Glu Lys Ile Arg 
    50                  55                  60                  


Ile Glu Lys Leu Ile Tyr Lys His Leu Pro Leu Phe Arg Pro Ala Val 
65                  70                  75                  80  


Glu Asp Leu Arg Lys Lys Ser Lys Glu Asn Val Lys Ser Pro Glu Leu 
                85                  90                  95      


Leu Ala Lys Val Ile Lys Asn Trp Ala Lys Val Ile Thr Tyr Tyr Arg 
            100                 105                 110         


Asp Lys Phe Thr His Tyr Val Phe Ile Asp Lys Arg His Glu Asn Lys 
        115                 120                 125             


Glu Phe Leu Asn Ala Glu Met Ser Val Ala Asn Asp Leu Asn Gln Ile 
    130                 135                 140                 


Phe Thr Ala Ser Ala Arg Val Ile Lys Glu Arg Phe Gly Leu Ser Thr 
145                 150                 155                 160 


Glu Leu Glu Phe Leu Thr Lys Gly Arg Tyr Arg Thr Gln Thr Ile Asp 
                165                 170                 175     


Gly Lys Arg Ser Thr Lys Leu Asn Pro Asn Phe Ile Tyr Ser Leu Gln 
            180                 185                 190         


Asp Lys Asn Glu Arg Leu Asn Lys Met Gly Leu Ile Phe Leu Ala Cys 
        195                 200                 205             


Gln Leu Ile Glu Lys Lys Tyr Ala Ser Met Leu Phe Asp Gln Gln Gly 
    210                 215                 220                 


Tyr Met Gly Arg Asp Ile Tyr Phe Asp Phe Thr Pro Ala Gln Cys Lys 
225                 230                 235                 240 


Tyr Ile Arg Glu Val Phe Ser Ala His Arg Ile Val Leu Pro Arg Gly 
                245                 250                 255     


Arg Met Asp Val Glu Arg Asn Glu Ile Thr Ile Ala Met Asp Met Phe 
            260                 265                 270         


Asn Glu Leu Gly Lys Cys Pro Lys Glu Leu Phe Glu Ile Ile Ser Lys 
        275                 280                 285             


Glu Glu Gln Lys Arg Phe Arg Thr Lys Ser Glu Thr Thr Gly Glu Glu 
    290                 295                 300                 


Val Leu Leu Met Arg His Ser Asp Arg Phe Ala Thr Leu Ala Leu Gln 
305                 310                 315                 320 


Tyr Ile Asp Asn Arg Lys Val Phe Glu Lys Ile Arg Phe Gln Leu Ser 
                325                 330                 335     


Leu Gly Lys Tyr Arg Tyr Lys Phe Tyr Asp Lys Thr Cys Val Asp Gly 
            340                 345                 350         


Asp Thr His Val Arg Ile Leu Gln Lys Glu Leu Asn Gly Phe Gly Arg 
        355                 360                 365             


Ile Asn Glu Ile Glu Leu Leu Lys Glu Glu Lys Trp Gly Gly Leu Ile 
    370                 375                 380                 


Arg Lys Phe Glu Asp Ala Lys Ile Asp Thr Ala Glu Thr Lys Pro Tyr 
385                 390                 395                 400 


Ile Thr Asp Gln Tyr Pro Gln Tyr Leu Phe Asn Gly Asn Arg Ile Gly 
                405                 410                 415     


Ile Tyr Phe Asn Ser Ala His Gly Lys Ala Met Arg Asn Gly Ala Tyr 
            420                 425                 430         


Ile Pro Asp Ile Glu Ser Gly Ala His Cys Ile Gln Pro Ile Cys Trp 
        435                 440                 445             


Ile Ser Asn Tyr Glu Leu Pro Ala Leu Ile Phe His His Ile Leu Thr 
    450                 455                 460                 


Lys Asp Glu Lys Lys Ser Leu Thr Glu Lys Ile Ile Ile Asp Cys Val 
465                 470                 475                 480 


Glu Arg Tyr Lys Lys Leu Phe Asn Asp Ile Ala Glu Gly Lys Val Ala 
                485                 490                 495     


Arg Thr Gly Asn Ala Thr Ser Asp Phe Glu Met Ile Ser Lys Glu Tyr 
            500                 505                 510         


Gly Ile Glu Lys Ser Asp Ile Pro Arg Glu Leu Gln Asp Tyr Phe Asn 
        515                 520                 525             


Gly Thr Glu Arg Asp Gly Ile Glu Gln Tyr Ala Lys Ala Gln Ile Arg 
    530                 535                 540                 


Glu Met Ile Glu Glu Asn Arg Ile Arg Leu Glu Gln Phe Asn Ser Lys 
545                 550                 555                 560 


Leu Lys Lys Ile Glu Asp Gly Glu Val Lys Tyr Gly Lys Arg Asp Tyr 
                565                 570                 575     


Thr Glu Ile Arg Thr Gly Glu Leu Ala Gln Tyr Leu Ala Lys Asp Ile 
            580                 585                 590         


Val Met Phe Met Pro Lys Ala Lys Tyr Lys Pro Thr Ser Lys Asn Tyr 
        595                 600                 605             


Asn Val Met Gln Ala Leu Leu Ala Thr Phe Asn Gly Ser Glu Ser Gly 
    610                 615                 620                 


Ser Thr Leu Asp Glu Val Asp Asp Met Phe Asp Asn Ile Lys Ala Cys 
625                 630                 635                 640 


Tyr Trp Lys Asn Glu Ser Asp Asn His Pro Phe Leu Glu Tyr Val Leu 
                645                 650                 655     


Gly Glu Glu Pro Lys Asp Ile Ile Ala Phe Tyr Lys Ile Tyr Leu Glu 
            660                 665                 670         


Leu Arg Gly Glu Tyr Leu Asp Lys Cys Ile Lys Lys Met Asp Leu Ala 
        675                 680                 685             


Thr Ile Pro Phe Ile His Thr Glu Arg Lys Arg Trp Glu Lys Arg Asp 
    690                 695                 700                 


Glu Lys Phe Phe Lys Glu Leu Ala Gln Arg Tyr Ala Thr Gln Pro Ile 
705                 710                 715                 720 


Glu Leu Pro Arg Gly Leu Tyr Asp Arg Ala Ile Lys Glu Tyr Leu Lys 
                725                 730                 735     


Ser Lys Ser Ile Leu Glu Asp Val Ile Ala Gln Glu Gln Cys Asn Val 
            740                 745                 750         


Thr Tyr Leu Ile Ala Arg Tyr Met Gln Asp Val Leu Lys Asp Asp Ser 
        755                 760                 765             


Gln Gln Phe Tyr Ser Leu Pro Arg His Tyr Ser Cys Leu Ser Glu Lys 
    770                 775                 780                 


Asp Lys Tyr Leu Ser Leu Thr Glu Arg Glu Ala Ile Ala Lys Ser Asp 
785                 790                 795                 800 


Ala Leu Asn Asn Phe Lys Lys Arg Glu Arg Glu Lys Glu Asn Glu Asn 
                805                 810                 815     


Arg Arg Gly Asn Arg Arg Tyr Asn Lys Gly Glu Asn Lys Asn Thr Ile 
            820                 825                 830         


Lys Asp Arg Asp Thr Glu Glu Lys Phe Asn Ser Leu Tyr Arg Lys Met 
        835                 840                 845             


Asp Asn Asn Glu Arg Ile Leu Arg Arg Tyr Lys Val Gln Asp Met Leu 
    850                 855                 860                 


Leu Tyr Leu Leu Ala Cys Asp Ile Ile Lys Gly Ile Met Arg Glu Asp 
865                 870                 875                 880 


Phe Gly Tyr Lys Leu Ser Met Ile Thr Asp Gly Lys Asn Ser Asn Phe 
                885                 890                 895     


Phe Asp Tyr Lys Met Pro Glu Phe Lys Thr Thr Ile Thr Leu Lys Glu 
            900                 905                 910         


Gly Lys Lys Phe Thr Ile Lys Gln Gln Tyr Leu Lys Ile Lys Asn Tyr 
        915                 920                 925             


Gly Asp Phe Leu Lys Phe Ile Phe Asp Leu Arg Ile Asp Ser Leu Leu 
    930                 935                 940                 


Ser Asn Gly Thr Lys Val Glu Ile Asp Arg Asn Ile Leu Glu Asp Glu 
945                 950                 955                 960 


Leu Ser Asn Tyr Asp Gly Ser Arg Pro Lys Val Phe Glu Thr Leu Leu 
                965                 970                 975     


Met Ile Glu Lys Ile Val Val Glu Lys His Lys Glu Leu Lys Asp Leu 
            980                 985                 990         


Glu His Ile Thr Phe Gly Asp Val  Leu Asn Val Ile Lys  Met Glu Glu 
        995                 1000                 1005             


Gly Glu  Lys Lys Ile Leu Arg  Leu Ile Arg Asn Ala  Phe Ser His 
    1010                 1015                 1020             


Asn Tyr  Tyr Pro Thr Ile Lys  Asp Val Asn Tyr Asp  Asn Met Pro 
    1025                 1030                 1035             


Glu Val  Ala Glu Ser Leu Lys  Asp Ile Leu Glu Lys  Glu Ser Lys 
    1040                 1045                 1050             


Lys Leu  Thr Asn 
    1055         


<210>  1682
<211>  1154
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1682

Leu Gly Ser Leu Pro Gln Ser Gly Thr Ser Gln Ala Tyr Ile Thr Leu 
1               5                   10                  15      


Thr His Ile Asp Arg Gln Leu Ala Tyr Ser Lys Ala Asp Ile Thr Asn 
            20                  25                  30          


Asp Gln Asp Val Leu Ser Phe Lys Ala Leu Trp Lys Asn Leu Asp Asn 
        35                  40                  45              


Asp Leu Glu Arg Lys Ser Arg Leu Arg Ser Leu Ile Leu Lys His Phe 
    50                  55                  60                  


Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys Leu Phe Glu Ser Lys 
65                  70                  75                  80  


Ser Ser Gly Asn Lys Ser Ser Lys Asn Lys Glu Leu Thr Lys Lys Glu 
                85                  90                  95      


Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu Asp Asn Leu Lys Ser 
            100                 105                 110         


Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp Phe Arg Asn Tyr Tyr 
        115                 120                 125             


Ser His Tyr Arg His Ser Gly Ser Ser Glu Leu Pro Leu Phe Asp Gly 
    130                 135                 140                 


Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp Val Ser Val Gln Arg 
145                 150                 155                 160 


Val Lys Arg Asp His Glu His Asn Asp Lys Val Asp Pro His Tyr His 
                165                 170                 175     


Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp Arg Tyr Gly His Asn 
            180                 185                 190         


Asp Asn Pro Ser Phe Lys His His Phe Val Asp Ser Glu Gly Met Val 
        195                 200                 205             


Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys Arg 
    210                 215                 220                 


Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly Phe Lys Gly Gly Thr 
225                 230                 235                 240 


Glu Thr Tyr Gln Gln Met Thr Asn Glu Val Phe Cys Arg Ser Arg Ile 
                245                 250                 255     


Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg Thr Asp Asp Trp Met 
            260                 265                 270         


Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys Pro Lys Pro Leu Tyr 
        275                 280                 285             


Asp Arg Leu Arg Glu Asp Asp Arg Ala Cys Phe Arg Val Pro Val Asp 
    290                 295                 300                 


Ile Leu Pro Asp Glu Asp Asp Thr Asp Gly Gly Gly Glu Asp Pro Phe 
305                 310                 315                 320 


Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Ala Leu 
                325                 330                 335     


Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser Leu Arg Phe His Ile 
            340                 345                 350         


Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys Lys Met Ile Gly Glu 
        355                 360                 365             


Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu Tyr Gly Phe Gly Arg 
    370                 375                 380                 


Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu Glu Trp Lys Arg Leu 
385                 390                 395                 400 


Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp Lys Pro Tyr Ile Ser 
                405                 410                 415     


Gln Thr Ser Pro His Tyr His Ile Glu Lys Gly Lys Ile Gly Leu Arg 
            420                 425                 430         


Phe Met Pro Glu Gly Gln His Leu Trp Pro Ser Pro Glu Val Gly Thr 
        435                 440                 445             


Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp Lys Arg Leu Thr Ala 
    450                 455                 460                 


Glu Ala Phe Leu Ser Val His Glu Leu Met Pro Met Met Phe Tyr Tyr 
465                 470                 475                 480 


Phe Leu Leu Arg Glu Lys Tyr Ser Glu Glu Val Ser Ala Glu Lys Val 
                485                 490                 495     


Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val Tyr Ala Val Tyr Asp 
            500                 505                 510         


Ala Phe Ala Arg Asp Glu Ile Asn Thr Leu Lys Glu Leu Asp Ala Cys 
        515                 520                 525             


Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu Pro Lys Gln Met Ile 
    530                 535                 540                 


Ala Ile Leu Ser Gln Glu His Lys Asn Met Glu Glu Lys Val Arg Lys 
545                 550                 555                 560 


Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His Arg Leu Asp Met Leu 
                565                 570                 575     


Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly Arg Lys Asn Ala Gly 
            580                 585                 590         


Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu Val Arg Asp Met Met 
        595                 600                 605             


Arg Phe Gln Pro Val Ala Lys Asp Ala Ser Gly Lys Pro Leu Asn Asn 
    610                 615                 620                 


Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu Gln Arg Ala Leu Ala 
625                 630                 635                 640 


Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro Tyr Phe Arg Gln Met 
                645                 650                 655     


Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe Leu His Asp Thr Arg 
            660                 665                 670         


Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr Arg Ser Tyr Leu Arg 
        675                 680                 685             


Ala Arg Lys Ala Phe Leu Glu Arg Ile Gly Arg Ser Asp Arg Met Glu 
    690                 695                 700                 


Asn Arg Pro Phe Leu Leu Leu Lys Glu Pro Lys Thr Asp Arg Gln Thr 
705                 710                 715                 720 


Leu Val Ala Gly Trp Lys Ser Glu Phe His Leu Pro Arg Gly Ile Phe 
                725                 730                 735     


Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met Gly Tyr Asp Glu Val 
            740                 745                 750         


Gly Ser Tyr Arg Glu Val Gly Phe Met Ala Lys Ala Val Pro Leu Tyr 
        755                 760                 765             


Phe Glu Arg Ala Cys Glu Asp Arg Val Gln Pro Phe Tyr Asp Ser Pro 
    770                 775                 780                 


Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys Gly Arg Phe Leu Ser 
785                 790                 795                 800 


Lys Glu Glu Arg Ala Glu Glu Trp Glu Arg Gly Lys Glu Arg Phe Arg 
                805                 810                 815     


Asp Leu Glu Ala Trp Ser His Ser Ala Ala Arg Arg Ile Glu Asp Ala 
            820                 825                 830         


Phe Ala Gly Ile Glu Tyr Ala Ser Pro Gly Asn Lys Lys Lys Ile Glu 
        835                 840                 845             


Gln Leu Leu Arg Asp Leu Ser Leu Trp Lys Ala Phe Glu Ser Lys Leu 
    850                 855                 860                 


Lys Val Arg Ala Asp Lys Ile Asn Leu Ala Lys Leu Lys Lys Glu Ile 
865                 870                 875                 880 


Leu Glu Ala Gln Glu His Pro Tyr His Asp Phe Lys Ser Trp Gln Lys 
                885                 890                 895     


Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln Asp Ile Ile Thr Trp 
            900                 905                 910         


Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys Val Glu Gly Leu Asp 
        915                 920                 925             


Thr Gly Thr Leu Tyr Leu Lys Asp Ile Arg Pro Asn Val Gln Glu Gln 
    930                 935                 940                 


Gly Ser Leu Asn Val Leu Asn Arg Val Lys Pro Met Arg Leu Pro Val 
945                 950                 955                 960 


Val Val Tyr Arg Ala Asp Ser Arg Gly His Val His Lys Glu Glu Ala 
                965                 970                 975     


Pro Leu Ala Thr Val Tyr Ile Glu Glu Arg Asp Thr Lys Leu Leu Lys 
            980                 985                 990         


Gln Gly Asn Phe Lys Ser Phe Val  Lys Asp Arg Arg Leu  Asn Gly Leu 
        995                 1000                 1005             


Phe Ser  Phe Val Asp Thr Gly  Gly Leu Ala Met Glu  Gln Tyr Pro 
    1010                 1015                 1020             


Ile Ser  Lys Leu Arg Val Glu  Tyr Glu Leu Ala Lys  Tyr Gln Thr 
    1025                 1030                 1035             


Ala Arg  Val Cys Val Phe Glu  Leu Thr Leu Arg Leu  Glu Glu Ser 
    1040                 1045                 1050             


Leu Leu  Ser Arg Tyr Pro His  Leu Pro Asp Glu Ser  Phe Arg Glu 
    1055                 1060                 1065             


Met Leu  Glu Ser Trp Ser Asp  Pro Leu Leu Ala Lys  Trp Pro Glu 
    1070                 1075                 1080             


Leu His  Gly Lys Val Arg Leu  Leu Ile Ala Val Arg  Asn Ala Phe 
    1085                 1090                 1095             


Ser His  Asn Gln Tyr Pro Met  Tyr Asp Glu Ala Val  Phe Ser Ser 
    1100                 1105                 1110             


Ile Arg  Lys Tyr Asp Pro Ser  Ser Pro Asp Ala Ile  Glu Glu Arg 
    1115                 1120                 1125             


Met Gly  Leu Asn Ile Ala His  Arg Leu Ser Glu Glu  Val Lys Gln 
    1130                 1135                 1140             


Ala Lys  Glu Thr Val Glu Arg  Ile Ile Gln Ala 
    1145                 1150                 


<210>  1683
<211>  1154
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1683

Leu Gly Ser Leu Pro Gln Ser Gly Thr Ser Gln Ala Tyr Ile Thr Leu 
1               5                   10                  15      


Thr His Ile Asp Arg Gln Leu Ala Tyr Ser Lys Ala Asp Ile Thr Asn 
            20                  25                  30          


Asp Gln Asp Val Leu Ser Phe Lys Ala Leu Trp Lys Asn Leu Asp Asn 
        35                  40                  45              


Asp Leu Glu Arg Lys Ser Arg Leu Arg Ser Leu Ile Leu Lys His Phe 
    50                  55                  60                  


Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys Leu Phe Glu Ser Lys 
65                  70                  75                  80  


Ser Ser Gly Asn Lys Ser Ser Lys Asn Lys Glu Leu Thr Lys Lys Glu 
                85                  90                  95      


Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu Asp Asn Leu Lys Ser 
            100                 105                 110         


Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp Phe Arg Asn Tyr Tyr 
        115                 120                 125             


Ser His Tyr Arg His Ser Gly Ser Ser Glu Leu Pro Leu Phe Asp Gly 
    130                 135                 140                 


Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp Val Ser Val Gln Arg 
145                 150                 155                 160 


Val Lys Arg Asp His Glu His Asn Asp Lys Val Asp Pro His Tyr His 
                165                 170                 175     


Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp Arg Tyr Gly His Asn 
            180                 185                 190         


Asp Asn Pro Ser Phe Lys His His Phe Val Asp Ser Glu Gly Met Val 
        195                 200                 205             


Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys Arg 
    210                 215                 220                 


Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly Phe Lys Gly Gly Thr 
225                 230                 235                 240 


Glu Thr Tyr Gln Gln Met Thr Asn Glu Val Phe Cys Arg Ser Arg Ile 
                245                 250                 255     


Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg Thr Asp Asp Trp Met 
            260                 265                 270         


Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys Pro Lys Pro Leu Tyr 
        275                 280                 285             


Asp Arg Leu Arg Glu Asp Asp Arg Ala Cys Phe Arg Val Pro Val Asp 
    290                 295                 300                 


Ile Leu Pro Asp Glu Asp Asp Thr Asp Gly Gly Gly Glu Asp Pro Phe 
305                 310                 315                 320 


Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Ala Leu 
                325                 330                 335     


Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser Leu Arg Phe His Ile 
            340                 345                 350         


Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys Lys Met Ile Gly Glu 
        355                 360                 365             


Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu Tyr Gly Phe Gly Arg 
    370                 375                 380                 


Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu Glu Trp Lys Arg Leu 
385                 390                 395                 400 


Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp Lys Pro Tyr Ile Ser 
                405                 410                 415     


Gln Thr Ser Pro His Tyr His Ile Glu Lys Gly Lys Ile Gly Leu Arg 
            420                 425                 430         


Phe Met Pro Glu Gly Gln His Leu Trp Pro Ser Pro Glu Val Gly Thr 
        435                 440                 445             


Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp Lys Arg Leu Thr Ala 
    450                 455                 460                 


Glu Ala Phe Leu Ser Val His Glu Leu Met Pro Met Met Phe Tyr Tyr 
465                 470                 475                 480 


Phe Leu Leu Arg Glu Lys Tyr Ser Glu Glu Val Ser Ala Glu Lys Val 
                485                 490                 495     


Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val Tyr Ala Val Tyr Asp 
            500                 505                 510         


Ala Phe Ala Arg Asp Glu Ile Asn Thr Leu Lys Glu Leu Asp Ala Cys 
        515                 520                 525             


Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu Pro Lys Gln Met Ile 
    530                 535                 540                 


Ala Ile Leu Ser Gln Glu His Lys Asn Met Glu Glu Lys Val Arg Lys 
545                 550                 555                 560 


Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His Arg Leu Asp Met Leu 
                565                 570                 575     


Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly Arg Lys Asn Ala Gly 
            580                 585                 590         


Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu Val Arg Asp Met Met 
        595                 600                 605             


Arg Phe Gln Pro Val Ala Lys Asp Ala Ser Gly Lys Pro Leu Asn Asn 
    610                 615                 620                 


Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu Gln Arg Ala Leu Ala 
625                 630                 635                 640 


Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro Tyr Phe Arg Gln Met 
                645                 650                 655     


Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe Leu His Asp Thr Arg 
            660                 665                 670         


Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr Arg Ser Tyr Leu Arg 
        675                 680                 685             


Ala Arg Lys Ala Phe Leu Glu Arg Ile Gly Arg Ser Asp Arg Met Glu 
    690                 695                 700                 


Asn Arg Pro Phe Leu Leu Leu Lys Glu Pro Lys Thr Asp Arg Gln Thr 
705                 710                 715                 720 


Leu Val Ala Gly Trp Lys Ser Glu Phe His Leu Pro Arg Gly Ile Phe 
                725                 730                 735     


Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met Gly Tyr Asp Glu Val 
            740                 745                 750         


Gly Ser Tyr Arg Glu Val Gly Phe Met Ala Lys Ala Val Pro Leu Tyr 
        755                 760                 765             


Phe Glu Arg Ala Cys Glu Asp Arg Val Gln Pro Phe Tyr Asp Ser Pro 
    770                 775                 780                 


Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys Gly Arg Phe Leu Ser 
785                 790                 795                 800 


Lys Glu Glu Arg Ala Glu Glu Trp Glu Arg Gly Lys Glu Arg Phe Arg 
                805                 810                 815     


Asp Leu Glu Ala Trp Ser His Ser Ala Ala Arg Arg Ile Glu Asp Ala 
            820                 825                 830         


Phe Ala Gly Ile Glu Tyr Ala Ser Pro Gly Asn Lys Lys Lys Ile Glu 
        835                 840                 845             


Gln Leu Leu Arg Asp Leu Ser Leu Trp Lys Ala Phe Glu Ser Lys Leu 
    850                 855                 860                 


Lys Val Arg Ala Asp Lys Ile Asn Leu Ala Lys Leu Lys Lys Glu Ile 
865                 870                 875                 880 


Leu Glu Ala Gln Glu His Pro Tyr His Asp Phe Lys Ser Trp Gln Lys 
                885                 890                 895     


Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln Asp Ile Ile Thr Trp 
            900                 905                 910         


Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys Val Glu Gly Leu Asp 
        915                 920                 925             


Thr Gly Thr Leu Tyr Leu Lys Asp Ile Arg Pro Asn Val Gln Glu Gln 
    930                 935                 940                 


Gly Ser Leu Asn Val Leu Asn Arg Val Lys Pro Met Arg Leu Pro Val 
945                 950                 955                 960 


Val Val Tyr Arg Ala Asp Ser Arg Gly His Val His Lys Glu Glu Ala 
                965                 970                 975     


Pro Leu Ala Thr Val Tyr Ile Glu Glu Arg Asp Thr Lys Leu Leu Lys 
            980                 985                 990         


Gln Gly Asn Phe Lys Ser Phe Val  Lys Asp Arg Arg Leu  Asn Gly Leu 
        995                 1000                 1005             


Phe Ser  Phe Val Asp Thr Gly  Gly Leu Ala Met Glu  Gln Tyr Pro 
    1010                 1015                 1020             


Ile Ser  Lys Leu Arg Val Glu  Tyr Glu Leu Ala Lys  Tyr Gln Thr 
    1025                 1030                 1035             


Ala Arg  Val Cys Val Phe Glu  Leu Thr Leu Arg Leu  Glu Glu Ser 
    1040                 1045                 1050             


Leu Leu  Ser Arg Tyr Pro His  Leu Pro Asp Glu Ser  Phe Arg Glu 
    1055                 1060                 1065             


Met Leu  Glu Ser Trp Ser Asp  Pro Leu Leu Ala Lys  Trp Pro Glu 
    1070                 1075                 1080             


Leu His  Gly Lys Val Arg Leu  Leu Ile Ala Val Arg  Asn Ala Phe 
    1085                 1090                 1095             


Ser His  Asn Gln Tyr Pro Met  Tyr Asp Glu Ala Val  Phe Ser Ser 
    1100                 1105                 1110             


Ile Arg  Lys Tyr Asp Pro Ser  Ser Pro Asp Ala Ile  Glu Glu Arg 
    1115                 1120                 1125             


Met Gly  Leu Asn Ile Ala His  Arg Leu Ser Glu Glu  Val Lys Gln 
    1130                 1135                 1140             


Ala Lys  Glu Thr Val Glu Arg  Ile Ile Gln Ala 
    1145                 1150                 


<210>  1684
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1684

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Val Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Ser Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1685
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1685

Leu Gln Lys Gln Asp Lys Leu Phe Val Asp Arg Lys Lys Asn Ala Ile 
1               5                   10                  15      


Phe Ala Phe Pro Lys Tyr Ile Thr Ile Met Glu Asn Lys Glu Lys Pro 
            20                  25                  30          


Glu Pro Ile Tyr Tyr Glu Leu Thr Asp Lys His Phe Trp Ala Ala Phe 
        35                  40                  45              


Leu Asn Leu Ala Arg His Asn Val Tyr Thr Thr Val Asn His Ile Asn 
    50                  55                  60                  


Lys Leu Leu Glu Ile Ala Glu Leu Lys Asn Asp Glu Asp Val Leu Asn 
65                  70                  75                  80  


Ile Lys Asp Ser Trp Asn Lys Gln Ala Glu Lys Leu Asp Lys Lys Val 
                85                  90                  95      


Arg Leu Arg Asn Leu Leu Met Arg His Phe Pro Phe Leu Glu Ala Ala 
            100                 105                 110         


Ala Tyr Glu Lys Thr Thr Ser Lys Asp Ser Asn Ser Lys Glu Gln Lys 
        115                 120                 125             


Glu Lys Glu Gln Ala Glu Ala Leu Ser Leu Asp Asn Leu Lys Asn Val 
    130                 135                 140                 


Leu Phe Ile Phe Leu Glu Lys Leu Gln Ser Leu Arg Asn Tyr Tyr Ser 
145                 150                 155                 160 


His Tyr Lys Tyr Ser Glu Glu Ala Gln Lys Pro Thr Phe Glu Asn Asp 
                165                 170                 175     


Leu Leu Lys Asn Met Tyr Lys Ile Phe Asp Thr Asn Val Arg Leu Val 
            180                 185                 190         


Lys Arg Asp Tyr Met His His Glu Asn Val Asp Met Gln Arg Asp Phe 
        195                 200                 205             


Ser His Leu Asn Arg Lys Lys Gln Glu Gly Gln Thr Arg Lys Ile Ile 
    210                 215                 220                 


Ala Asn Pro Asn Phe Arg Tyr His Phe Ala Asp Glu Lys Gly Asp Met 
225                 230                 235                 240 


Thr Ile Ala Gly Leu Leu Phe Phe Ile Ser Leu Phe Leu Asp Lys Lys 
                245                 250                 255     


Asp Ala Ile Trp Met Gln Lys Lys Leu Lys Gly Phe Lys Asp Gly Arg 
            260                 265                 270         


Asn Leu Arg Glu Gln Met Thr Asn Glu Val Phe Cys Arg Ser Arg Ile 
        275                 280                 285             


Ser Leu Pro Lys Leu Lys Leu Glu Asn Val Gln Thr Lys Asp Trp Met 
    290                 295                 300                 


Gln Leu Asp Met Leu Asn Glu Leu Val Arg Cys Pro Lys Ser Leu Tyr 
305                 310                 315                 320 


Glu Arg Leu Arg Glu Lys Asp Arg Glu Ser Phe Lys Val Pro Phe Asp 
                325                 330                 335     


Ile Phe Ser Asp Asp Tyr Asp Ala Glu Glu Glu Pro Phe Lys Asn Thr 
            340                 345                 350         


Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe 
        355                 360                 365             


Asp Leu Asn Glu Ile Phe Glu Gln Leu Arg Phe Gln Ile Asp Leu Gly 
    370                 375                 380                 


Thr Tyr His Phe Ser Ile Tyr Asn Lys Arg Ile Gly Asp Glu Asp Glu 
385                 390                 395                 400 


Val Arg His Leu Thr His His Leu Tyr Gly Phe Ala Arg Ile Gln Asp 
                405                 410                 415     


Phe Ala Pro Gln Asn Gln Pro Glu Glu Trp Arg Lys Leu Val Lys Asp 
            420                 425                 430         


Leu Asp His Phe Glu Thr Ser Gln Glu Pro Tyr Ile Ser Lys Thr Ala 
        435                 440                 445             


Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Lys Phe Cys Ser 
    450                 455                 460                 


Thr His Asn Asn Leu Phe Pro Ser Leu Lys Thr Glu Lys Thr Cys Asn 
465                 470                 475                 480 


Gly Arg Ser Lys Phe Asn Leu Gly Thr Gln Phe Thr Ala Glu Ala Phe 
                485                 490                 495     


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu 
            500                 505                 510         


Thr Lys Asp His Pro Lys Gly Lys Gly Ile Asn Lys Ile Glu Lys Ile 
        515                 520                 525             


Ile Arg Lys Glu Ile Ser Asn Ile Tyr Ala Ile Tyr Asp Ala Phe Ala 
    530                 535                 540                 


Asn Asn Glu Ile Asn Ser Ile Ala Asp Leu Thr Arg Arg Leu Gln Asn 
545                 550                 555                 560 


Thr Asn Ile Leu Gln Gly His Leu Pro Lys Gln Met Ile Ser Ile Leu 
                565                 570                 575     


Glu Gly Arg Gln Lys Asp Met Glu Lys Glu Ala Glu Arg Lys Ile Gly 
            580                 585                 590         


Glu Met Ile Asp Asp Thr Gln Arg Arg Leu Asp Leu Leu Cys Lys Gln 
        595                 600                 605             


Thr Asn Gln Lys Ile Arg Ile Gly Lys Arg Asn Ala Gly Leu Leu Lys 
    610                 615                 620                 


Ser Gly Lys Ile Ala Asp Trp Leu Val Asn Asp Met Met Arg Phe Gln 
625                 630                 635                 640 


Pro Val Gln Lys Asp Gln Asn Asn Ile Pro Ile Asn Asn Ser Lys Ala 
                645                 650                 655     


Asn Ser Thr Glu Tyr Arg Met Leu Gln Arg Ala Leu Ala Leu Phe Gly 
            660                 665                 670         


Ser Glu Asn Phe Arg Leu Lys Ala Tyr Phe Asn Gln Met Asn Leu Val 
        675                 680                 685             


Gly Asn Asp Asn Pro His Pro Phe Leu Ala Glu Thr Gln Trp Glu His 
    690                 695                 700                 


Gln Thr Asn Ile Leu Ser Phe Tyr Arg Asn Tyr Leu Glu Ala Arg Lys 
705                 710                 715                 720 


Lys Tyr Leu Lys Gly Leu Lys Pro Gln Asn Trp Lys Gln Tyr Gln His 
                725                 730                 735     


Phe Leu Ile Leu Lys Val Gln Lys Thr Asn Arg Asn Thr Leu Val Thr 
            740                 745                 750         


Gly Trp Lys Asn Ser Phe Asn Leu Pro Arg Gly Ile Phe Thr Gln Pro 
        755                 760                 765             


Ile Arg Glu Trp Phe Glu Lys His Asn Asn Ser Lys Arg Ile Tyr Asp 
    770                 775                 780                 


Gln Ile Leu Ser Phe Gly Arg Val Gly Phe Val Ala Lys Ala Ile Pro 
785                 790                 795                 800 


Leu Tyr Phe Ala Glu Glu Tyr Lys Asp Asn Val Gln Pro Phe Tyr Asp 
                805                 810                 815     


Tyr Pro Phe Asn Ile Gly Asn Lys Leu Lys Pro Lys Lys Gly Gln Phe 
            820                 825                 830         


Leu Asp Lys Lys Glu Arg Val Glu Leu Trp Gln Lys Asn Lys Glu Leu 
        835                 840                 845             


Phe Lys Asn Tyr Pro Pro Glu Lys Arg Lys Thr Asp Leu Ala Tyr Leu 
    850                 855                 860                 


Asp Phe Leu Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys 
865                 870                 875                 880 


Asn Gln Asp Ile Val Thr Trp Leu Met Phe Lys Glu Leu Phe Asn Met 
                885                 890                 895     


Ala Thr Val Glu Gly Leu Lys Ile Gly Glu Ile His Leu Arg Asp Ile 
            900                 905                 910         


Asp Thr Asn Thr Ala Asn Glu Glu Ser Asn Asn Ile Leu Asn Arg Ile 
        915                 920                 925             


Met Pro Met Lys Leu Pro Val Lys Thr Tyr Glu Thr Asp Asn Lys Gly 
    930                 935                 940                 


Asn Ile Leu Lys Glu Arg Pro Leu Ala Thr Phe Tyr Ile Glu Glu Thr 
945                 950                 955                 960 


Glu Thr Lys Val Leu Lys Gln Gly Asn Phe Lys Val Leu Ala Lys Asp 
                965                 970                 975     


Arg Arg Leu Asn Gly Leu Leu Ser Phe Ala Glu Thr Thr Asp Ile Asp 
            980                 985                 990         


Leu Glu Lys Asn Pro Ile Thr Lys  Leu Ser Val Asp His  Glu Leu Ile 
        995                 1000                 1005             


Lys Tyr  Gln Thr Thr Arg Ile  Ser Ile Phe Glu Met  Thr Leu Gly 
    1010                 1015                 1020             


Leu Glu  Lys Lys Leu Ile Asp  Lys Tyr Ser Thr Leu  Pro Thr Asp 
    1025                 1030                 1035             


Ser Phe  Arg Asn Met Leu Glu  Arg Trp Leu Gln Cys  Lys Ala Asn 
    1040                 1045                 1050             


Arg Pro  Glu Leu Lys Asn Cys  Val Asn Ser Leu Ile  Ala Val Arg 
    1055                 1060                 1065             


Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met Tyr Asp  Ala Thr Leu 
    1070                 1075                 1080             


Phe Ala  Glu Val Lys Lys Phe  Thr Leu Phe Pro Ser  Val Asp Thr 
    1085                 1090                 1095             


Lys Lys  Ile Glu Leu Asn Ile  Ala Pro Gln Leu Leu  Glu Ile Val 
    1100                 1105                 1110             


Gly Lys  Ala Ile Lys Glu Ile  Glu Lys Ser Glu Asn  Lys Asn 
    1115                 1120                 1125         


<210>  1686
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1686

Leu Gln Lys Gln Asp Lys Leu Phe Val Asp Arg Lys Lys Asn Ala Ile 
1               5                   10                  15      


Phe Ala Phe Pro Lys Tyr Ile Thr Ile Met Glu Asn Lys Glu Lys Pro 
            20                  25                  30          


Glu Pro Ile Tyr Tyr Glu Leu Thr Asp Lys His Phe Trp Ala Ala Phe 
        35                  40                  45              


Leu Asn Leu Ala Arg His Asn Val Tyr Thr Thr Val Asn His Ile Asn 
    50                  55                  60                  


Lys Leu Leu Glu Ile Ala Glu Leu Lys Asn Asp Glu Asp Val Leu Asn 
65                  70                  75                  80  


Ile Lys Asp Ser Trp Asn Lys Gln Ala Glu Lys Leu Asp Lys Lys Val 
                85                  90                  95      


Arg Leu Arg Asn Leu Leu Met Arg His Phe Pro Phe Leu Glu Ala Ala 
            100                 105                 110         


Ala Tyr Glu Lys Thr Thr Ser Lys Asp Ser Asn Ser Lys Glu Gln Lys 
        115                 120                 125             


Glu Lys Glu Gln Ala Glu Ala Leu Ser Leu Asp Asn Leu Lys Asn Val 
    130                 135                 140                 


Leu Phe Ile Phe Leu Glu Lys Leu Gln Ser Leu Arg Asn Tyr Tyr Ser 
145                 150                 155                 160 


His Tyr Lys Tyr Ser Glu Glu Ala Gln Lys Pro Thr Phe Glu Asn Asp 
                165                 170                 175     


Leu Leu Lys Asn Met Tyr Lys Ile Phe Asp Thr Asn Val Arg Leu Val 
            180                 185                 190         


Lys Arg Asp Tyr Met His His Glu Asn Val Asp Met Gln Arg Asp Phe 
        195                 200                 205             


Ser His Leu Asn Arg Lys Lys Gln Glu Gly Gln Thr Arg Lys Ile Ile 
    210                 215                 220                 


Ala Asn Pro Asn Phe Arg Tyr His Phe Ala Asp Glu Lys Gly Asp Met 
225                 230                 235                 240 


Thr Ile Ala Gly Leu Leu Phe Phe Ile Ser Leu Phe Leu Asp Lys Lys 
                245                 250                 255     


Asp Ala Ile Trp Met Gln Lys Lys Leu Lys Gly Phe Lys Asp Gly Arg 
            260                 265                 270         


Asn Leu Arg Glu Gln Met Thr Asn Glu Val Phe Cys Arg Ser Arg Ile 
        275                 280                 285             


Ser Leu Pro Lys Leu Lys Leu Glu Asn Val Gln Thr Lys Asp Trp Met 
    290                 295                 300                 


Gln Leu Asp Met Leu Asn Glu Leu Val Arg Cys Pro Lys Ser Leu Tyr 
305                 310                 315                 320 


Glu Arg Leu Arg Glu Lys Asp Arg Glu Ser Phe Lys Val Pro Phe Asp 
                325                 330                 335     


Ile Phe Ser Asp Asp Tyr Asp Ala Glu Glu Glu Pro Phe Lys Asn Thr 
            340                 345                 350         


Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe 
        355                 360                 365             


Asp Leu Asn Glu Ile Phe Glu Gln Leu Arg Phe Gln Ile Asp Leu Gly 
    370                 375                 380                 


Thr Tyr His Phe Ser Ile Tyr Asn Lys Arg Ile Gly Asp Glu Asp Glu 
385                 390                 395                 400 


Val Arg His Leu Thr His His Leu Tyr Gly Phe Ala Arg Ile Gln Asp 
                405                 410                 415     


Phe Ala Pro Gln Asn Gln Pro Glu Glu Trp Arg Lys Leu Val Lys Asp 
            420                 425                 430         


Leu Asp His Phe Glu Thr Ser Gln Glu Pro Tyr Ile Ser Lys Thr Ala 
        435                 440                 445             


Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Lys Phe Cys Ser 
    450                 455                 460                 


Thr His Asn Asn Leu Phe Pro Ser Leu Lys Thr Glu Lys Thr Cys Asn 
465                 470                 475                 480 


Gly Arg Ser Lys Phe Asn Leu Gly Thr Gln Phe Thr Ala Glu Ala Phe 
                485                 490                 495     


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu 
            500                 505                 510         


Thr Lys Asp His Pro Lys Gly Lys Gly Ile Asn Lys Ile Glu Lys Ile 
        515                 520                 525             


Ile Arg Lys Glu Ile Ser Asn Ile Tyr Ala Ile Tyr Asp Ala Phe Ala 
    530                 535                 540                 


Asn Asn Glu Ile Asn Ser Ile Ala Asp Leu Thr Arg Arg Leu Gln Asn 
545                 550                 555                 560 


Thr Asn Ile Leu Gln Gly His Leu Pro Lys Gln Met Ile Ser Ile Leu 
                565                 570                 575     


Glu Gly Arg Gln Lys Asp Met Glu Lys Glu Ala Glu Arg Lys Ile Gly 
            580                 585                 590         


Glu Met Ile Asp Asp Thr Gln Arg Arg Leu Asp Leu Leu Cys Lys Gln 
        595                 600                 605             


Thr Asn Gln Lys Ile Arg Ile Gly Lys Arg Asn Ala Gly Leu Leu Lys 
    610                 615                 620                 


Ser Gly Lys Ile Ala Asp Trp Leu Val Asn Asp Met Met Arg Phe Gln 
625                 630                 635                 640 


Pro Val Gln Lys Asp Gln Asn Asn Ile Pro Ile Asn Asn Ser Lys Ala 
                645                 650                 655     


Asn Ser Thr Glu Tyr Arg Met Leu Gln Arg Ala Leu Ala Leu Phe Gly 
            660                 665                 670         


Ser Glu Asn Phe Arg Leu Lys Ala Tyr Phe Asn Gln Met Asn Leu Val 
        675                 680                 685             


Gly Asn Asp Asn Pro His Pro Phe Leu Ala Glu Thr Gln Trp Glu His 
    690                 695                 700                 


Gln Thr Asn Ile Leu Ser Phe Tyr Arg Asn Tyr Leu Glu Ala Arg Lys 
705                 710                 715                 720 


Lys Tyr Leu Lys Gly Leu Lys Pro Gln Asn Trp Lys Gln Tyr Gln His 
                725                 730                 735     


Phe Leu Ile Leu Lys Val Gln Lys Thr Asn Arg Asn Thr Leu Val Thr 
            740                 745                 750         


Gly Trp Lys Asn Ser Phe Asn Leu Pro Arg Gly Ile Phe Thr Gln Pro 
        755                 760                 765             


Ile Arg Glu Trp Phe Glu Lys His Asn Asn Ser Lys Arg Ile Tyr Asp 
    770                 775                 780                 


Gln Ile Leu Ser Phe Gly Arg Val Gly Phe Val Ala Lys Ala Ile Pro 
785                 790                 795                 800 


Leu Tyr Phe Ala Glu Glu Tyr Lys Asp Asn Val Gln Pro Phe Tyr Asp 
                805                 810                 815     


Tyr Pro Phe Asn Ile Gly Asn Lys Leu Lys Pro Lys Lys Gly Gln Phe 
            820                 825                 830         


Leu Asp Lys Lys Glu Arg Val Glu Leu Trp Gln Lys Asn Lys Glu Leu 
        835                 840                 845             


Phe Lys Asn Tyr Pro Pro Glu Lys Arg Lys Thr Asp Leu Ala Tyr Leu 
    850                 855                 860                 


Asp Phe Leu Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys 
865                 870                 875                 880 


Asn Gln Asp Ile Val Thr Trp Leu Met Phe Lys Glu Leu Phe Asn Met 
                885                 890                 895     


Ala Thr Val Glu Gly Leu Lys Ile Gly Glu Ile His Leu Arg Asp Ile 
            900                 905                 910         


Asp Thr Asn Thr Ala Asn Glu Glu Ser Asn Asn Ile Leu Asn Arg Ile 
        915                 920                 925             


Met Pro Met Lys Leu Pro Val Lys Thr Tyr Glu Thr Asp Asn Lys Gly 
    930                 935                 940                 


Asn Ile Leu Lys Glu Arg Pro Leu Ala Thr Phe Tyr Ile Glu Glu Thr 
945                 950                 955                 960 


Glu Thr Lys Val Leu Lys Gln Gly Asn Phe Lys Val Leu Ala Lys Asp 
                965                 970                 975     


Arg Arg Leu Asn Gly Leu Leu Ser Phe Ala Glu Thr Thr Asp Ile Asp 
            980                 985                 990         


Leu Glu Lys Asn Pro Ile Thr Lys  Leu Ser Val Asp His  Glu Leu Ile 
        995                 1000                 1005             


Lys Tyr  Gln Thr Thr Arg Ile  Ser Ile Phe Glu Met  Thr Leu Gly 
    1010                 1015                 1020             


Leu Glu  Lys Lys Leu Ile Asp  Lys Tyr Ser Thr Leu  Pro Thr Asp 
    1025                 1030                 1035             


Ser Phe  Arg Asn Met Leu Glu  Arg Trp Leu Gln Cys  Lys Ala Asn 
    1040                 1045                 1050             


Arg Pro  Glu Leu Lys Asn Cys  Val Asn Ser Leu Ile  Ala Val Arg 
    1055                 1060                 1065             


Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met Tyr Asp  Ala Thr Leu 
    1070                 1075                 1080             


Phe Ala  Glu Val Lys Lys Phe  Thr Leu Phe Pro Ser  Val Asp Thr 
    1085                 1090                 1095             


Lys Lys  Ile Glu Leu Asn Ile  Ala Pro Gln Leu Leu  Glu Ile Val 
    1100                 1105                 1110             


Gly Lys  Ala Ile Lys Glu Ile  Glu Lys Ser Glu Asn  Lys Asn 
    1115                 1120                 1125         


<210>  1687
<211>  1267
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1687

Met Ala Phe Asp Lys Pro Arg Pro Lys Arg Arg Gln Ala Arg Ser Asp 
1               5                   10                  15      


Phe Tyr Ile Thr Asp Lys Ala Ile Met Gly Gly Tyr Phe Asn Leu Ala 
            20                  25                  30          


Gln Leu Asn Phe Phe Lys Thr Leu Met Glu Ile Phe Thr Lys Ala Gly 
        35                  40                  45              


Ile Asp Val Ser Lys Ile Lys Gln Asp Asn Ser Pro Lys Tyr Leu Met 
    50                  55                  60                  


Ile Leu Ile Lys Lys Leu Thr His Asp Asp Glu Lys Ile Asp Asp Lys 
65                  70                  75                  80  


Lys Trp Ala Asp Ala Leu Asp Leu Ser Asn Glu Cys Leu Leu Lys Leu 
                85                  90                  95      


Gln Gln Leu Leu Tyr Lys His Phe Pro Phe Leu Gly Pro Val Met Gly 
            100                 105                 110         


Gly Glu Ala Ser Tyr Asn Ile Tyr Lys Leu Lys Asp Gly His Pro Glu 
        115                 120                 125             


Val Lys Val Ala Asn Asp Val Met Arg Gly Met Lys Leu Glu Asp Cys 
    130                 135                 140                 


Leu Ala Val Leu Arg His Phe Ala Leu Cys Leu Asn Asp Cys Arg Asn 
145                 150                 155                 160 


Phe Tyr Thr His Phe Asn Pro Tyr Asn Ser Ile Asp Ala Gln Lys Glu 
                165                 170                 175     


Gln Tyr Leu Ser Gln Asn Lys Val Ala Val Trp Leu Glu Lys Val Lys 
            180                 185                 190         


Asp Ala Ser Arg Arg Ile Val Lys Gln Asn Asn Gln Leu Thr Ser Gln 
        195                 200                 205             


Asp Met Glu Phe Leu Thr Gly Ile Asp His Met Lys Pro Gln Asp Lys 
    210                 215                 220                 


Val Asp Asp Phe Gly Asn Ile Met Thr Asp Lys Lys Gly Tyr Thr Ile 
225                 230                 235                 240 


Lys Glu Tyr Val Glu Tyr Glu Asp Tyr Tyr Phe Arg Ile Arg Gly Lys 
                245                 250                 255     


Arg Tyr Leu Val Asp Ala Ala Gly Ala Lys Leu Ala Asp Gln Glu Pro 
            260                 265                 270         


Arg Asn Ala Leu Ser Asp Phe Gly Val Val Phe Leu Cys Thr Leu Phe 
        275                 280                 285             


Leu Glu Asn Asp Gln Ser Arg Arg Met Leu Asp Glu Leu Arg Leu Phe 
    290                 295                 300                 


Glu Thr Gly Pro Tyr Asp Gly Ser Arg Asp Gly Asp Glu Phe Lys Asn 
305                 310                 315                 320 


Asp Ile Leu Arg Glu Ile Leu Leu Phe Tyr Arg Ala Arg Ile Pro Arg 
                325                 330                 335     


Gly Lys Arg Leu Asp Pro Met Asp Asp Thr Thr Leu Leu Ala Met Asp 
            340                 345                 350         


Met Leu Asn Glu Leu Arg Lys Cys Pro Met Pro Leu Tyr Asp Val Leu 
        355                 360                 365             


Ser Arg Glu Gly Gln Arg Phe Phe Glu Asp Glu Val Lys His Pro Asn 
    370                 375                 380                 


Asp Leu Thr Pro Glu Val Ala Lys Arg Leu Arg Ser Ser Asp Arg Phe 
385                 390                 395                 400 


Pro Tyr Leu Ala Leu Arg Tyr Ile Asp Leu Asn Lys Cys Phe Asp Asn 
                405                 410                 415     


Ile Arg Phe Gln Val Gln Leu Gly Lys Phe Arg Tyr Lys Phe Tyr Asp 
            420                 425                 430         


Lys Thr Thr Ile Asp Gly Glu Gln Val Val Arg Gly Leu Gln Lys Glu 
        435                 440                 445             


Val Asn Ala Tyr Gly Arg Phe Gln Asp Val Glu His Tyr Arg Gln Glu 
    450                 455                 460                 


Lys Tyr Ala Asp Met Leu Gln Gln Thr Glu Leu Val Glu Thr Gly Glu 
465                 470                 475                 480 


Glu Asp Ile Thr Ile Ala Asn Phe Ile Pro Asp Thr Pro Gln Ser Ser 
                485                 490                 495     


Pro Tyr Leu Ser Asp Arg Thr Ala Ser Tyr Asn Ile His Asn Asn Arg 
            500                 505                 510         


Ile Gly Leu Leu Trp Asn Met Pro Gly Glu His Glu Val Leu Thr Gly 
        515                 520                 525             


Asp Glu Lys Met Tyr Leu Pro Asp Leu Asn Val Asp Asp Asn Gly Lys 
    530                 535                 540                 


Ala Asp Val Phe Leu Pro Ala Pro Lys Ala Ser Leu Ser Val Arg Asp 
545                 550                 555                 560 


Leu Pro Ala Leu Val Phe Tyr Leu Tyr Leu Gln Asn Gln His Pro Asp 
                565                 570                 575     


Leu Thr Pro Ala Glu Ala Ile Ile Gln Gln Lys Tyr Asn Ala Leu Val 
            580                 585                 590         


Arg Phe Phe Glu Asp Val Ser Thr Gly Arg Leu Leu Pro Val Lys Gly 
        595                 600                 605             


Ile Ala Glu Leu Glu Ala Ala Ile Asp Lys Tyr Gly His Leu Thr Val 
    610                 615                 620                 


His Glu Ile Pro Glu Lys Leu Arg Asp Tyr Leu Ala Gly Val Ala Gly 
625                 630                 635                 640 


Thr Glu Asp Asp Asp Asp Cys Ala Asp Arg Leu Asp Cys Tyr Ala Met 
                645                 650                 655     


Gly Ile Leu Glu Lys Arg Tyr Arg Gln Val Ala Ala Arg Ile Asp Gln 
            660                 665                 670         


Leu Lys Glu Ala Arg Lys Met Val Gly Asp Lys Met Asn Arg Tyr Gly 
        675                 680                 685             


Lys Lys Ser Tyr Ile Asp Val Arg Pro Arg Arg Leu Ala Glu Gln Leu 
    690                 695                 700                 


Ala Gln Ser Ile Val Glu Trp Gln Pro Ala Thr Asp Asn Gly Arg His 
705                 710                 715                 720 


Lys Met Thr Gly Lys Asn Phe Gln Arg Leu Ile Ala Phe Leu Ala Arg 
                725                 730                 735     


Tyr Ile Asp Glu Val Pro Leu Gln Glu Leu Lys Asp Leu Met Thr Arg 
            740                 745                 750         


Ala Arg Leu Leu Glu Gly Pro Val Ala His Pro Phe Leu Gln Gln Val 
        755                 760                 765             


Leu Asp Lys Asn Pro Leu Asn Ile Glu Val Leu Tyr Asp Leu Tyr Phe 
    770                 775                 780                 


Lys Glu Glu Lys Arg Tyr Leu Asp Lys Tyr Ile Asp Ile Glu Ile Asn 
785                 790                 795                 800 


Lys Gln Gly Glu Glu Val Tyr Trp Leu Lys Ala Asp Ala Asp Leu Ser 
                805                 810                 815     


Lys Ile Pro Phe Leu Asn Ser Ser Arg Leu Arg Phe His Lys Arg Asp 
            820                 825                 830         


Ser Ala Ser Phe Gln Arg Leu Ala Ala Arg Tyr Leu Gln Val Asp Gly 
        835                 840                 845             


Arg Gln Ser Thr Ile Leu Leu Pro Asp Gly Leu Phe Thr Pro His Ile 
    850                 855                 860                 


Leu Ser Ala Leu Lys Ser Thr Leu Tyr Gln Glu Asn His Asp Leu Gln 
865                 870                 875                 880 


Asp His Leu Gln Asp Gln Glu Leu Asn Gln Asn Ala Ser Tyr Leu Met 
                885                 890                 895     


Ser Val Tyr Leu Glu His Val Leu His Asp Ser Ala Gln Pro Phe Tyr 
            900                 905                 910         


Leu Ser Asn Ser Asn Asp Ser Pro Phe Ala Arg Arg Tyr Asp Leu Phe 
        915                 920                 925             


Ala Ile Val Gln Asn Lys Lys Arg Gly Ala Glu Leu Leu Pro Gly Pro 
    930                 935                 940                 


Leu Thr Pro Val Glu Ile Asn Arg Arg Leu Thr Ala Lys Thr Pro Asp 
945                 950                 955                 960 


Gly Ser Ala Lys Leu Ile Glu Arg Asp Ile Val Ala Leu Leu Glu Asp 
                965                 970                 975     


Met Ala Arg Lys Thr Glu Gln Arg Ile His Lys Leu Pro Gln Asp Leu 
            980                 985                 990         


Tyr Leu Lys Lys Lys Lys Gln Ala  Gln Glu Glu Arg Ile  Lys Leu Gln 
        995                 1000                 1005             


Arg Arg  Leu Lys His Lys Ile  Thr Asp Val Lys Lys  Asn Glu Arg 
    1010                 1015                 1020             


Ala Ile  Arg Arg Tyr Lys Thr  Gln Asp Met Ala Ile  Phe Leu Met 
    1025                 1030                 1035             


Ala Gln  Gln Met Leu Ala Asn  Gln Leu Ser Trp Gln  Asn Gln Glu 
    1040                 1045                 1050             


Gly Glu  Val Pro Leu Lys Leu  Ala Asn Val Cys Asn  Asp Gly Phe 
    1055                 1060                 1065             


Leu Ser  Gln Thr Met Lys Val  Ser Phe Pro Tyr Glu  Val Pro Leu 
    1070                 1075                 1080             


Lys Glu  Asp Lys Thr Lys Lys  Val Thr Ile Asp Ile  Val Gln Asp 
    1085                 1090                 1095             


Asn Met  Ser Leu Lys Asn Tyr  Gly Leu Leu Tyr Lys  Leu Tyr His 
    1100                 1105                 1110             


Asp Glu  Arg Val Val Thr Leu  Leu Gln Asn Ile Val  Asp Gln Gln 
    1115                 1120                 1125             


Gln Ile  Ser Phe Ala Glu Leu  Thr Ala Glu Leu Ser  Leu Tyr Asp 
    1130                 1135                 1140             


Gln Asn  Arg Ser Lys Ala Phe  Ser Asn Phe Gln Gln  Phe Glu Lys 
    1145                 1150                 1155             


Leu Ala  Phe Glu Thr Asn Arg  Glu Ala Leu Ser Asn  Pro Glu His 
    1160                 1165                 1170             


Arg Gly  Phe Phe Leu Glu Lys  Val Asn Lys Lys Asn  Gln Val Ile 
    1175                 1180                 1185             


Arg Tyr  Glu Arg Arg Asn Asn  Phe Asp Ala Leu Leu  Asp Leu Leu 
    1190                 1195                 1200             


Asp Ala  Ile Glu Ala His Gln  Leu Asp Pro Arg Asp  Arg Gln Trp 
    1205                 1210                 1215             


Leu Thr  Ser Val Arg Asn Ala  Phe Cys His Asn Ser  Tyr Tyr Lys 
    1220                 1225                 1230             


Ile Asp  Met Gln Gln Ile Glu  Lys Lys Leu Pro Thr  Ile Ile Gln 
    1235                 1240                 1245             


Gln Ile  Val Glu Ile Val Gln  Arg Ile Thr Asp Lys  Ala Ser His 
    1250                 1255                 1260             


Pro Ser  Asn Arg 
    1265         


<210>  1688
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1688

Leu Gln Lys Gln Asp Lys Leu Phe Val Asp Arg Lys Lys Asn Ala Ile 
1               5                   10                  15      


Phe Ala Phe Pro Lys Tyr Ile Thr Ile Met Glu Asn Lys Glu Lys Pro 
            20                  25                  30          


Glu Pro Ile Tyr Tyr Glu Leu Thr Asp Lys His Phe Trp Ala Ala Phe 
        35                  40                  45              


Leu Asn Leu Ala Arg His Asn Val Tyr Thr Thr Ile Asn His Ile Asn 
    50                  55                  60                  


Arg Arg Leu Glu Ile Ala Glu Leu Lys Asp Asp Gly Tyr Met Met Gly 
65                  70                  75                  80  


Ile Lys Gly Ser Trp Asn Glu Gln Ala Lys Lys Leu Asp Lys Lys Val 
                85                  90                  95      


Arg Leu Arg Asp Leu Ile Met Lys His Phe Pro Phe Leu Glu Ala Ala 
            100                 105                 110         


Ala Tyr Glu Met Thr Asn Ser Lys Ser Pro Asn Asn Lys Glu Gln Arg 
        115                 120                 125             


Glu Lys Glu Gln Ser Glu Ala Leu Ser Leu Asn Asn Leu Lys Asn Val 
    130                 135                 140                 


Leu Phe Ile Phe Leu Glu Lys Leu Gln Val Leu Arg Asn Tyr Tyr Ser 
145                 150                 155                 160 


His Tyr Lys Tyr Ser Glu Glu Ser Pro Lys Pro Ile Phe Glu Thr Ser 
                165                 170                 175     


Leu Leu Lys Asn Met Tyr Lys Val Phe Asp Ala Asn Val Arg Leu Val 
            180                 185                 190         


Lys Arg Asp Tyr Met His His Glu Asn Ile Asp Met Gln Arg Asp Phe 
        195                 200                 205             


Thr His Leu Asn Arg Lys Lys Gln Val Gly Arg Thr Lys Asn Ile Ile 
    210                 215                 220                 


Asp Ser Pro Asn Phe His Tyr His Phe Ala Asp Lys Glu Gly Asn Met 
225                 230                 235                 240 


Thr Ile Ala Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Asp Lys Lys 
                245                 250                 255     


Asp Ala Ile Trp Met Gln Lys Lys Leu Lys Gly Phe Lys Asp Gly Arg 
            260                 265                 270         


Asn Leu Arg Glu Gln Met Thr Asn Glu Val Phe Cys Arg Ser Arg Ile 
        275                 280                 285             


Ser Leu Pro Lys Leu Lys Leu Glu Asn Val Gln Thr Lys Asp Trp Met 
    290                 295                 300                 


Gln Leu Asp Met Leu Asn Glu Leu Val Arg Cys Pro Lys Ser Leu Tyr 
305                 310                 315                 320 


Glu Arg Leu Arg Glu Lys Asp Arg Glu Ser Phe Lys Val Pro Phe Asp 
                325                 330                 335     


Ile Phe Ser Asp Asp Tyr Asn Ala Glu Glu Glu Pro Phe Lys Asn Thr 
            340                 345                 350         


Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe 
        355                 360                 365             


Asp Leu Asn Glu Ile Phe Glu Gln Leu Arg Phe Gln Ile Asp Leu Gly 
    370                 375                 380                 


Thr Tyr His Phe Ser Ile Tyr Asn Lys Arg Ile Gly Asp Glu Asp Glu 
385                 390                 395                 400 


Val Arg His Leu Thr His His Leu Tyr Gly Phe Ala Arg Ile Gln Asp 
                405                 410                 415     


Phe Ala Pro Gln Asn Gln Pro Glu Glu Trp Arg Lys Leu Val Lys Asp 
            420                 425                 430         


Leu Asp His Phe Glu Thr Ser Gln Glu Pro Tyr Ile Ser Lys Thr Ala 
        435                 440                 445             


Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Lys Phe Cys Ser 
    450                 455                 460                 


Ala His Asn Asn Leu Phe Pro Ser Leu Gln Thr Asp Lys Thr Cys Asn 
465                 470                 475                 480 


Gly Arg Ser Lys Phe Asn Leu Gly Thr Gln Phe Thr Ala Glu Ala Phe 
                485                 490                 495     


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu 
            500                 505                 510         


Thr Lys Asp Tyr Ser Arg Lys Glu Ser Ala Asp Lys Val Glu Gly Ile 
        515                 520                 525             


Ile Arg Lys Glu Ile Ser Asn Ile Tyr Ala Ile Tyr Asp Ala Phe Ala 
    530                 535                 540                 


Asn Asn Glu Ile Asn Ser Ile Ala Asp Leu Thr Arg Arg Leu Gln Asn 
545                 550                 555                 560 


Thr Asn Ile Leu Gln Gly His Leu Pro Lys Gln Met Ile Ser Ile Leu 
                565                 570                 575     


Lys Gly Arg Gln Lys Asp Met Gly Lys Glu Ala Glu Arg Lys Ile Gly 
            580                 585                 590         


Glu Met Ile Asp Asp Thr Gln Arg Arg Leu Asp Leu Leu Cys Lys Gln 
        595                 600                 605             


Thr Asn Gln Lys Ile Arg Ile Gly Lys Arg Asn Ala Gly Leu Leu Lys 
    610                 615                 620                 


Ser Gly Lys Ile Ala Asp Trp Leu Val Asn Asp Met Met Arg Phe Gln 
625                 630                 635                 640 


Pro Val Gln Lys Asp Gln Asn Asn Ile Pro Ile Asn Asn Ser Lys Ala 
                645                 650                 655     


Asn Ser Thr Glu Tyr Arg Met Leu Gln Arg Ala Leu Ala Leu Phe Gly 
            660                 665                 670         


Ser Glu Asn Phe Arg Leu Lys Ala Tyr Phe Asn Gln Met Asn Leu Val 
        675                 680                 685             


Gly Asn Asp Asn Pro His Pro Phe Leu Ala Glu Thr Gln Trp Glu His 
    690                 695                 700                 


Gln Thr Asn Ile Leu Ser Phe Tyr Arg Asn Tyr Leu Glu Ala Arg Lys 
705                 710                 715                 720 


Lys Tyr Leu Lys Gly Leu Lys Pro Gln Asn Trp Lys Gln Tyr Gln His 
                725                 730                 735     


Phe Leu Ile Leu Lys Val Gln Lys Thr Asn Arg Asn Thr Leu Val Thr 
            740                 745                 750         


Gly Trp Lys Asn Ser Phe Asn Leu Pro Arg Gly Ile Phe Thr Gln Pro 
        755                 760                 765             


Ile Arg Glu Trp Phe Glu Lys His Asn Asn Ser Lys Arg Ile Tyr Asp 
    770                 775                 780                 


Gln Ile Leu Ser Phe Asp Arg Val Gly Phe Val Ala Lys Ala Ile Pro 
785                 790                 795                 800 


Leu Tyr Phe Ala Glu Glu Tyr Lys Asp Asn Val Gln Pro Phe Tyr Asp 
                805                 810                 815     


Tyr Pro Phe Asn Ile Gly Asn Arg Leu Lys Pro Lys Lys Arg Gln Phe 
            820                 825                 830         


Leu Asp Lys Lys Glu Arg Val Glu Leu Trp Gln Lys Asn Lys Glu Leu 
        835                 840                 845             


Phe Lys Asn Tyr Pro Ser Glu Lys Lys Lys Thr Asp Leu Ala Tyr Leu 
    850                 855                 860                 


Asp Phe Leu Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys 
865                 870                 875                 880 


Asn Gln Asp Ile Val Thr Trp Leu Met Phe Lys Glu Leu Phe Asn Met 
                885                 890                 895     


Ala Thr Val Glu Gly Leu Lys Ile Gly Glu Ile His Leu Arg Asp Ile 
            900                 905                 910         


Asp Thr Asn Thr Ala Asn Glu Glu Ser Asn Asn Ile Leu Asn Arg Ile 
        915                 920                 925             


Met Pro Met Lys Leu Pro Val Lys Thr Tyr Glu Thr Asp Asn Lys Gly 
    930                 935                 940                 


Asn Ile Leu Lys Glu Arg Pro Leu Ala Thr Phe Tyr Ile Glu Glu Thr 
945                 950                 955                 960 


Glu Thr Lys Val Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys Asp 
                965                 970                 975     


Arg Arg Leu Asn Gly Leu Phe Ser Phe Ala Glu Thr Thr Asp Leu Asn 
            980                 985                 990         


Leu Glu Glu His Pro Ile Ser Lys  Leu Ser Val Asp Leu  Glu Leu Ile 
        995                 1000                 1005             


Lys Tyr  Gln Thr Thr Arg Ile  Ser Ile Phe Glu Met  Thr Leu Gly 
    1010                 1015                 1020             


Leu Glu  Lys Lys Leu Ile Asp  Lys Tyr Ser Thr Leu  Pro Thr Asp 
    1025                 1030                 1035             


Ser Phe  Arg Asn Met Leu Glu  Arg Trp Leu Gln Cys  Lys Ala Asn 
    1040                 1045                 1050             


Arg Pro  Glu Leu Lys Asn Tyr  Val Asn Ser Leu Ile  Ala Val Arg 
    1055                 1060                 1065             


Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met Tyr Asp  Ala Thr Leu 
    1070                 1075                 1080             


Phe Ala  Glu Val Lys Lys Phe  Thr Leu Phe Pro Ser  Val Asp Thr 
    1085                 1090                 1095             


Lys Lys  Ile Glu Leu Asn Ile  Ala Pro Gln Leu Leu  Glu Ile Val 
    1100                 1105                 1110             


Gly Lys  Ala Ile Lys Glu Ile  Glu Lys Ser Glu Asn  Lys Asn 
    1115                 1120                 1125         


<210>  1689
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1689

Leu Gln Lys Gln Asp Lys Leu Phe Val Asp Arg Lys Lys Asn Ala Ile 
1               5                   10                  15      


Phe Ala Phe Pro Lys Tyr Ile Thr Ile Met Glu Asn Lys Glu Lys Pro 
            20                  25                  30          


Glu Pro Ile Tyr Tyr Glu Leu Thr Asp Lys His Phe Trp Ala Ala Phe 
        35                  40                  45              


Leu Asn Leu Ala Arg His Asn Val Tyr Thr Thr Ile Asn His Ile Asn 
    50                  55                  60                  


Arg Arg Leu Glu Ile Ala Glu Leu Lys Asp Asp Gly His Met Met Asp 
65                  70                  75                  80  


Ile Lys Gly Ser Trp Asn Glu Gln Ala Lys Lys Leu Asp Lys Lys Val 
                85                  90                  95      


Arg Leu Arg Asp Leu Ile Met Lys His Phe Pro Phe Leu Glu Ala Ala 
            100                 105                 110         


Ala Tyr Glu Ile Thr Asn Ser Lys Ser Pro Asn Asn Lys Glu Gln Arg 
        115                 120                 125             


Glu Lys Glu Gln Ser Glu Ala Leu Ser Leu Asn Asn Leu Lys Asn Val 
    130                 135                 140                 


Leu Phe Ile Phe Leu Glu Lys Leu Gln Val Leu Arg Asn Tyr Tyr Ser 
145                 150                 155                 160 


His Tyr Lys Tyr Ser Glu Glu Ser Pro Lys Pro Thr Phe Glu Thr Ser 
                165                 170                 175     


Leu Leu Lys Asn Met Tyr Lys Val Phe Asp Ala Asn Val Arg Leu Val 
            180                 185                 190         


Lys Arg Asp Tyr Met His His Glu Asn Ile Asp Met Gln Arg Asp Phe 
        195                 200                 205             


Thr His Leu Asn Arg Lys Lys Gln Val Gly Arg Thr Lys Asn Ile Ile 
    210                 215                 220                 


Asp Ser Pro Asn Phe His Tyr His Phe Ala Asp Lys Glu Gly Asn Met 
225                 230                 235                 240 


Thr Ile Ala Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Asp Lys Lys 
                245                 250                 255     


Asp Ala Ile Trp Met Gln Lys Lys Leu Lys Gly Phe Lys Asp Gly Arg 
            260                 265                 270         


Asn Leu Arg Glu Gln Met Thr Asn Glu Val Phe Cys Arg Ser Arg Ile 
        275                 280                 285             


Ser Leu Pro Lys Leu Lys Leu Glu Asn Val Gln Thr Lys Asp Trp Met 
    290                 295                 300                 


Gln Leu Asp Met Leu Asn Glu Leu Val Arg Cys Pro Lys Ser Leu Tyr 
305                 310                 315                 320 


Glu Arg Leu Arg Glu Lys Asp Arg Glu Ser Phe Lys Val Pro Phe Asp 
                325                 330                 335     


Ile Phe Ser Asp Asp Tyr Asp Ala Glu Glu Glu Pro Phe Lys Asn Thr 
            340                 345                 350         


Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe 
        355                 360                 365             


Asp Leu Asn Glu Ile Phe Glu Gln Leu Arg Phe Gln Ile Asp Leu Gly 
    370                 375                 380                 


Thr Tyr His Phe Ser Ile Tyr Asn Lys Arg Ile Gly Asp Glu Asp Glu 
385                 390                 395                 400 


Val Arg His Leu Thr His His Leu Tyr Gly Phe Ala Arg Ile Gln Asp 
                405                 410                 415     


Phe Ala Pro Gln Asn Gln Pro Glu Glu Trp Arg Lys Leu Val Lys Asp 
            420                 425                 430         


Leu Asp His Phe Glu Thr Ser Gln Glu Pro Tyr Ile Ser Lys Thr Ala 
        435                 440                 445             


Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Lys Phe Cys Ser 
    450                 455                 460                 


Thr His Asn Asn Leu Phe Pro Ser Leu Lys Arg Glu Lys Thr Cys Asn 
465                 470                 475                 480 


Gly Arg Ser Lys Phe Asn Leu Gly Thr Gln Phe Thr Ala Glu Ala Phe 
                485                 490                 495     


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu 
            500                 505                 510         


Thr Lys Asp Tyr Ser Arg Lys Glu Ser Ala Asp Lys Val Glu Gly Ile 
        515                 520                 525             


Ile Arg Lys Glu Ile Ser Asn Ile Tyr Ala Ile Tyr Asp Ala Phe Ala 
    530                 535                 540                 


Asn Gly Glu Ile Asn Ser Ile Ala Asp Leu Thr Cys Arg Leu Gln Lys 
545                 550                 555                 560 


Thr Asn Ile Leu Gln Gly His Leu Pro Lys Gln Met Ile Ser Ile Leu 
                565                 570                 575     


Glu Gly Arg Gln Lys Asp Met Glu Lys Glu Ala Glu Arg Lys Ile Gly 
            580                 585                 590         


Glu Met Ile Asp Asp Thr Gln Arg Arg Leu Asp Leu Leu Cys Lys Gln 
        595                 600                 605             


Thr Asn Gln Lys Ile Arg Ile Gly Lys Arg Asn Ala Gly Leu Leu Lys 
    610                 615                 620                 


Ser Gly Lys Ile Ala Asp Trp Leu Val Asn Asp Met Met Arg Phe Gln 
625                 630                 635                 640 


Pro Val Gln Lys Asp Gln Asn Asn Ile Pro Ile Asn Asn Ser Lys Ala 
                645                 650                 655     


Asn Ser Thr Glu Tyr Arg Met Leu Gln Arg Ala Leu Ala Leu Phe Gly 
            660                 665                 670         


Ser Glu Asn Phe Arg Leu Lys Ala Tyr Phe Asn Gln Met Asn Leu Val 
        675                 680                 685             


Gly Asn Asp Asn Pro His Pro Phe Leu Ala Glu Thr Gln Trp Glu His 
    690                 695                 700                 


Gln Thr Asn Ile Leu Ser Phe Tyr Arg Asn Tyr Leu Glu Ala Arg Lys 
705                 710                 715                 720 


Lys Tyr Leu Lys Gly Leu Lys Pro Gln Asn Trp Lys Gln Tyr Gln His 
                725                 730                 735     


Phe Leu Ile Leu Lys Val Gln Lys Thr Asn Arg Asn Thr Leu Val Thr 
            740                 745                 750         


Gly Trp Lys Asn Ser Phe Asn Leu Pro Arg Gly Ile Phe Thr Gln Pro 
        755                 760                 765             


Ile Arg Glu Trp Phe Glu Lys His Asn Asn Ser Lys Arg Ile Tyr Asp 
    770                 775                 780                 


Gln Ile Leu Ser Phe Asp Arg Val Gly Phe Val Ala Lys Ala Ile Pro 
785                 790                 795                 800 


Leu Tyr Phe Ala Glu Glu Tyr Lys Asp Asn Val Gln Pro Phe Tyr Asp 
                805                 810                 815     


Tyr Pro Phe Asn Ile Gly Asn Lys Leu Lys Pro Gln Lys Gly Gln Phe 
            820                 825                 830         


Leu Asp Lys Lys Glu Arg Val Glu Leu Trp Gln Lys Asn Lys Glu Leu 
        835                 840                 845             


Phe Lys Asn Tyr Pro Ser Glu Lys Lys Lys Thr Asp Leu Ala Tyr Leu 
    850                 855                 860                 


Asp Phe Leu Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys 
865                 870                 875                 880 


Asn Gln Asp Ile Val Thr Trp Leu Met Phe Lys Glu Leu Phe Lys Thr 
                885                 890                 895     


Thr Thr Val Glu Gly Leu Lys Ile Gly Glu Ile His Leu Arg Asp Ile 
            900                 905                 910         


Asp Thr Asn Thr Ala Asn Glu Glu Ser Asn Asn Ile Leu Asn Arg Ile 
        915                 920                 925             


Met Pro Met Lys Leu Pro Val Lys Thr Tyr Glu Thr Asp Asn Lys Gly 
    930                 935                 940                 


Asn Ile Leu Lys Glu Arg Pro Leu Ala Thr Phe Tyr Ile Glu Glu Thr 
945                 950                 955                 960 


Glu Thr Lys Val Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys Asp 
                965                 970                 975     


Arg Arg Leu Asn Gly Leu Phe Ser Phe Ala Glu Thr Thr Asp Leu Asn 
            980                 985                 990         


Leu Glu Glu His Pro Ile Ser Lys  Leu Ser Val Asp His  Glu Leu Ile 
        995                 1000                 1005             


Lys Tyr  Gln Thr Lys Arg Val  Arg Ile Phe Glu Met  Ile Leu Arg 
    1010                 1015                 1020             


Leu Glu  Lys Lys Leu Ile Asp  Lys Tyr Ser Thr Leu  Pro Thr Asp 
    1025                 1030                 1035             


Ser Phe  Arg Asn Met Leu Glu  Arg Trp Leu Gln Cys  Lys Ala Asn 
    1040                 1045                 1050             


Arg Pro  Glu Leu Lys Asn Tyr  Val Asn Ser Leu Ile  Ala Val Arg 
    1055                 1060                 1065             


Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met Tyr Asp  Ala Thr Leu 
    1070                 1075                 1080             


Phe Ala  Glu Val Lys Lys Phe  Thr Leu Phe Pro Ser  Val Asp Thr 
    1085                 1090                 1095             


Lys Lys  Ile Glu Leu Asn Ile  Ala Pro Gln Leu Leu  Glu Ile Val 
    1100                 1105                 1110             


Gly Lys  Ala Ile Lys Glu Ile  Glu Lys Ser Glu Asn  Lys Asn 
    1115                 1120                 1125         


<210>  1690
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1690

Leu Gln Lys Gln Asp Lys Leu Phe Val Asp Arg Lys Lys Asn Ala Ile 
1               5                   10                  15      


Phe Ala Phe Pro Lys Tyr Ile Thr Ile Met Glu Asn Lys Glu Lys Pro 
            20                  25                  30          


Glu Pro Ile Tyr Tyr Glu Leu Thr Asp Lys His Phe Trp Ala Ala Phe 
        35                  40                  45              


Leu Asn Leu Ala Arg His Asn Val Tyr Thr Thr Ile Asn His Ile Asn 
    50                  55                  60                  


Arg Arg Leu Glu Ile Ala Glu Leu Lys Asp Asp Gly Tyr Met Met Asp 
65                  70                  75                  80  


Ile Lys Gly Ser Trp Asn Glu Gln Ala Lys Lys Leu Asp Lys Lys Val 
                85                  90                  95      


Arg Leu Arg Asp Leu Ile Met Lys His Phe Pro Phe Leu Glu Ala Ala 
            100                 105                 110         


Ala Tyr Glu Met Thr Asn Ser Lys Ser Pro Asn Asn Lys Glu Gln Arg 
        115                 120                 125             


Glu Lys Glu Gln Ser Glu Ala Leu Ser Leu Asn Asn Leu Lys Asn Val 
    130                 135                 140                 


Leu Phe Ile Phe Leu Glu Lys Leu Gln Val Leu Arg Asn Tyr Tyr Ser 
145                 150                 155                 160 


His Tyr Lys Tyr Ser Glu Glu Ser Pro Lys Pro Thr Phe Glu Thr Ser 
                165                 170                 175     


Leu Leu Lys Asn Met Tyr Lys Val Phe Asp Ala Asn Val Arg Leu Val 
            180                 185                 190         


Lys Arg Asp Tyr Met His His Glu Asn Ile Asp Met Gln Arg Asp Phe 
        195                 200                 205             


Thr His Leu Asn Arg Lys Lys Gln Val Gly Arg Thr Lys Asn Ile Ile 
    210                 215                 220                 


Asp Ser Pro Asn Phe His Tyr His Phe Ala Asp Lys Glu Gly Asn Met 
225                 230                 235                 240 


Thr Ile Ala Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Asp Lys Lys 
                245                 250                 255     


Asp Ala Ile Trp Met Gln Lys Lys Leu Lys Gly Phe Lys Asp Gly Arg 
            260                 265                 270         


Asn Leu Arg Glu Gln Met Thr Asn Glu Val Phe Cys Arg Ser Arg Ile 
        275                 280                 285             


Ser Leu Pro Lys Leu Lys Leu Glu Asn Val Gln Thr Lys Asp Trp Met 
    290                 295                 300                 


Gln Leu Asp Met Leu Asn Glu Leu Val Arg Cys Pro Lys Ser Leu Tyr 
305                 310                 315                 320 


Glu Arg Leu Arg Glu Lys Asp Arg Glu Ser Phe Lys Val Pro Phe Asp 
                325                 330                 335     


Ile Phe Ser Asp Asp Tyr Asp Ala Glu Glu Glu Pro Phe Lys Asn Thr 
            340                 345                 350         


Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe 
        355                 360                 365             


Asp Leu Asn Glu Ile Phe Glu Gln Leu Arg Phe Gln Ile Asp Leu Gly 
    370                 375                 380                 


Thr Tyr His Phe Ser Ile Tyr Asn Lys Arg Ile Gly Asp Glu Asp Glu 
385                 390                 395                 400 


Val Arg His Leu Thr His His Leu Tyr Gly Phe Ala Arg Ile Gln Asp 
                405                 410                 415     


Phe Ala Gln Gln Asn Gln Pro Glu Glu Trp Arg Lys Leu Val Lys Asp 
            420                 425                 430         


Leu Asp His Phe Glu Thr Ser Gln Glu Pro Tyr Ile Ser Lys Thr Ala 
        435                 440                 445             


Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Lys Phe Cys Ser 
    450                 455                 460                 


Thr His Asn Asn Leu Phe Pro Ser Leu Lys Arg Glu Lys Thr Cys Asn 
465                 470                 475                 480 


Gly Arg Ser Lys Phe Asn Leu Gly Thr Gln Phe Thr Ala Glu Ala Phe 
                485                 490                 495     


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu 
            500                 505                 510         


Thr Lys Asp His Pro Lys Gly Glu Gly Val Asn Lys Ile Glu Lys Ile 
        515                 520                 525             


Ile Arg Thr Glu Ile Ser Asn Ile Tyr Asp Ile Tyr Asp Ala Phe Ala 
    530                 535                 540                 


Asn Gly Glu Ile Asn Ser Ile Ala Asp Leu Thr Cys Arg Leu Gln Lys 
545                 550                 555                 560 


Thr Asn Ile Leu Gln Gly His Leu Pro Lys Gln Met Ile Ser Ile Leu 
                565                 570                 575     


Glu Gly Arg Gln Lys Asp Met Glu Lys Glu Ala Glu Arg Lys Ile Gly 
            580                 585                 590         


Glu Met Ile Asp Asp Thr Gln Arg Arg Leu Asp Leu Leu Cys Lys Gln 
        595                 600                 605             


Thr Asn Gln Lys Ile Arg Ile Gly Lys Arg Asn Ala Gly Leu Leu Lys 
    610                 615                 620                 


Ser Gly Lys Ile Ala Asp Trp Leu Val Asn Asp Met Met Arg Phe Gln 
625                 630                 635                 640 


Pro Val Gln Lys Asp Gln Asn Asn Ile Pro Ile Asn Asn Ser Lys Ala 
                645                 650                 655     


Asn Ser Thr Glu Tyr Arg Met Leu Gln Arg Ala Leu Ala Leu Phe Gly 
            660                 665                 670         


Ser Glu Asn Phe Arg Leu Lys Ala Tyr Phe Asn Gln Met Asn Leu Val 
        675                 680                 685             


Gly Asn Asp Asn Pro His Pro Phe Leu Ala Glu Thr Gln Trp Glu His 
    690                 695                 700                 


Gln Thr Asn Ile Leu Ser Phe Tyr Arg Asn Tyr Leu Glu Thr Arg Lys 
705                 710                 715                 720 


Lys Tyr Leu Lys Gly Leu Lys Pro Gln Asn Trp Lys Gln Tyr Gln His 
                725                 730                 735     


Phe Leu Ile Leu Lys Val Gln Lys Thr Asn Arg Asn Thr Leu Val Thr 
            740                 745                 750         


Gly Trp Lys Asn Ser Phe Asn Leu Pro Arg Gly Ile Phe Thr Gln Pro 
        755                 760                 765             


Ile Arg Glu Trp Phe Glu Lys His Asn Asn Ser Lys Arg Ile Tyr Asp 
    770                 775                 780                 


Gln Ile Leu Ser Phe Asp Arg Val Gly Phe Val Ala Lys Ala Ile Pro 
785                 790                 795                 800 


Leu Tyr Phe Ala Glu Glu Tyr Arg Asp Asn Val Gln Pro Phe Tyr Asp 
                805                 810                 815     


Tyr Pro Phe Asn Ile Gly Asn Lys Leu Lys Pro Gln Lys Gly Gln Phe 
            820                 825                 830         


Leu Asp Lys Glu Glu Arg Val Glu Leu Trp Gln Lys Asn Lys Glu Leu 
        835                 840                 845             


Phe Lys Asn Tyr Pro Ser Glu Lys Lys Lys Thr Asp Leu Ala Tyr Leu 
    850                 855                 860                 


Asp Phe Leu Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys 
865                 870                 875                 880 


Asn Gln Asp Ile Val Thr Trp Leu Met Phe Lys Glu Leu Phe Asn Met 
                885                 890                 895     


Ala Thr Val Glu Gly Leu Lys Ile Gly Glu Ile His Leu Arg Asp Ile 
            900                 905                 910         


Asp Thr Asn Thr Ala Lys Ala Glu Ser Asn Asn Ile Leu Asn Arg Ile 
        915                 920                 925             


Met Pro Met Lys Leu Pro Val Lys Thr Tyr Lys Ile Asn Asn Lys Gly 
    930                 935                 940                 


Lys Met Glu Met Glu Lys Pro Leu Ala Thr Phe Tyr Ile Glu Glu Thr 
945                 950                 955                 960 


Glu Thr Lys Val Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys Asp 
                965                 970                 975     


Arg Arg Leu Asn Gly Leu Phe Ser Phe Ala Glu Thr Thr Asp Leu Asn 
            980                 985                 990         


Leu Glu Glu His Pro Ile Ser Lys  Leu Ser Val Asp His  Glu Leu Ile 
        995                 1000                 1005             


Lys Tyr  Gln Thr Thr Arg Val  Arg Ile Phe Glu Met  Ile Leu Arg 
    1010                 1015                 1020             


Leu Glu  Lys Lys Leu Ile Asn  Lys Tyr Pro Thr Leu  Pro Thr Tyr 
    1025                 1030                 1035             


Ser Phe  Lys Asn Met Leu Glu  Ser Trp Leu Glu Asp  Lys Thr Asn 
    1040                 1045                 1050             


Ser Ala  Glu Leu Asn Asn Tyr  Val Asp Cys Leu Ile  Ala Val Arg 
    1055                 1060                 1065             


Asn Ala  Phe Ala His Asn Gln  Tyr Pro Met Tyr Asn  Pro Lys Leu 
    1070                 1075                 1080             


Phe Ala  Glu Val Lys Lys Phe  Ser Leu Phe Pro Ser  Ser Asn Thr 
    1085                 1090                 1095             


Lys Lys  Thr Glu Leu Asn Ile  Ala Ser Gln Leu Leu  Arg Ile Val 
    1100                 1105                 1110             


Glu Lys  Ala Ile Asp Glu Ile  Glu Lys Ser Glu Asn  Lys Asn 
    1115                 1120                 1125         


<210>  1691
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1691

Met Glu Thr Lys Gln Gln Val Gly Lys Gly Ile Ser Tyr Asp His Arg 
1               5                   10                  15      


Arg Pro Asp Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asp Gly Val Ile Gln Glu Phe Ala Met Arg Leu Asn Arg 
        35                  40                  45              


Glu Tyr Asp Pro Glu Asn Lys Asn Gln Ser Leu Phe Ser Tyr Phe Asn 
    50                  55                  60                  


Ile Asn Ala Ser Phe Thr Asp Trp Glu Arg Gly Val Asn Ile Leu Lys 
65                  70                  75                  80  


Glu Tyr Trp Pro Met Met Glu Phe Ile Asp Arg Pro Ala Thr Asp Lys 
                85                  90                  95      


Gln Phe Glu Ala Glu Lys Pro Glu Asn Arg Glu Ala Ala Lys Arg Lys 
            100                 105                 110         


Tyr Phe Leu Ala Thr Leu Gly Ala Leu Leu Thr Ser Ile Lys Asp Leu 
        115                 120                 125             


Arg His Tyr Tyr Thr His Tyr Tyr His Pro Pro Val His Leu Asn Asp 
    130                 135                 140                 


Asp Leu Phe Leu Phe Leu Asp His Ala Leu Leu Tyr Thr Ala Phe Asp 
145                 150                 155                 160 


Val Lys Lys Thr Lys Met Lys Asp Asp Lys Thr Arg Gln Leu Leu Asn 
                165                 170                 175     


Gln Asn Leu Ser Leu Glu Leu Glu Lys Leu Lys Lys Leu Lys Val Glu 
            180                 185                 190         


Glu Leu Lys Lys Lys Lys Glu Lys Gly Ile Lys Val Asn Leu Gln Asp 
        195                 200                 205             


Glu Lys Gly Ile Leu Asn Ala Ile Tyr Asn Asp Ala Phe Ala His Ile 
    210                 215                 220                 


Ile Thr Lys Glu Lys Asp Ser Asp Lys Asp Lys Leu Glu Thr Arg Tyr 
225                 230                 235                 240 


Lys Ser Ile Leu Pro Gln Asp Glu Ala Ala Glu Thr Gly Ile Asn Ile 
                245                 250                 255     


Ser Ile Ser Gly Leu Ile Phe Leu Leu Ser Leu Phe Leu Ser Arg Lys 
            260                 265                 270         


Glu Ile Glu Gln Leu Lys Ser Asn Ile Glu Gly Tyr Lys Gly Lys Val 
        275                 280                 285             


Leu Asn Ile Glu Thr Glu Val Asp Arg Lys His Asn Ser Leu Lys Tyr 
    290                 295                 300                 


Met Ala Thr His Trp Val Phe Ser Ile Leu Ala Phe Lys Gly Leu Lys 
305                 310                 315                 320 


Gln Arg Leu Thr Asn Ser Phe Glu Lys Glu Ser Leu Leu Ile Gln Met 
                325                 330                 335     


Met Asp Glu Leu Asn Lys Val Pro Asp Glu Leu Tyr Gln Thr Leu Ser 
            340                 345                 350         


Glu Thr Ala Lys Lys Glu Phe Leu Glu Asp Ile Asn Glu Tyr Val Ser 
        355                 360                 365             


Glu Gly Asp Asp Asn Glu Lys Ala Thr Tyr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Ser Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gln Phe Pro Thr Leu Lys Phe Gln Ile Phe Val Gly 
                405                 410                 415     


Gln Tyr Leu His Asp Asn Arg Pro Lys Thr Leu Ala Ser Asn Gly Met 
            420                 425                 430         


Thr Ala Gln Arg Met Ile Lys Glu Lys Ile Asn Leu Phe Gly Asn Leu 
        435                 440                 445             


Ser Glu Val Thr Lys His Lys Ser Asp Phe Phe Glu Lys Glu Ser Ala 
    450                 455                 460                 


Ala Gln Gly Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Trp Ala Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Val Tyr Ile Asp Met Ile Gly Lys Glu Gly Lys Ala 
                485                 490                 495     


Lys Glu Ile Gln Val Gln Ile Asn Lys Tyr Arg Lys Gln Leu Asn Pro 
            500                 505                 510         


Ala Pro Gln Arg Asp Lys Arg Ile Ser Lys Lys Glu Ile Ile Glu Gln 
        515                 520                 525             


Leu Tyr Lys Glu Lys Val Val Tyr Gly Asp Pro Thr Leu Met Leu Ser 
    530                 535                 540                 


Ala Asn Glu Leu Met Ala Leu Leu Tyr Glu Leu Ile Val Asn Gly Lys 
545                 550                 555                 560 


Ser Gly Ala Glu Leu Glu Asn Lys Ile Val Glu Gln Ile Ile Ala Arg 
                565                 570                 575     


Tyr Glu Gln Ile Glu Ala Tyr Asp Pro Thr Thr Gln Gln Leu Pro Thr 
            580                 585                 590         


Asn Gln Met Pro His Lys Leu Gln Lys Ser Arg Lys Asp Ser Lys Val 
        595                 600                 605             


Thr Asp Thr Asp Lys Leu Leu Lys Thr Ile Asp Lys Glu Ile Asp Glu 
    610                 615                 620                 


Gly Asn Lys Lys Leu Glu Leu Ile Ala Cys His Arg Lys Glu Trp Glu 
625                 630                 635                 640 


Glu Ala Glu Gln Arg Lys Lys Ser Gly Lys Arg Asn Asn Pro Gly Thr 
                645                 650                 655     


Lys Ser Arg Lys His Leu Phe Tyr Ala Ser Glu Met Gly Glu Glu Ala 
            660                 665                 670         


Thr Trp Ile Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Pro Ala Arg 
        675                 680                 685             


Ala Glu Trp Lys Gly Thr His His Ser Glu Leu Gln Arg Leu Leu Ala 
    690                 695                 700                 


Phe Tyr Ser Thr Gln Arg Leu Glu Ala Trp Gln Leu Val Glu Ser Val 
705                 710                 715                 720 


Trp Thr Ala Asn Thr His Ser Phe Trp Glu Glu Asn Phe Lys Glu Ala 
                725                 730                 735     


Phe Tyr Lys Pro Glu Phe Glu Asn Phe Tyr Gly Ala Tyr Ile Glu Ile 
            740                 745                 750         


Arg Thr Lys Ile Leu Thr Thr Cys Arg Ser Ile Leu Glu Asn Asn Pro 
        755                 760                 765             


Glu Ala Thr Met Asn Asn Asp Thr Glu Lys Glu Trp Asp Lys Val Phe 
    770                 775                 780                 


Thr Leu Phe Asp Lys Arg Leu Tyr Arg Thr Ser Thr Thr Asp Glu Gln 
785                 790                 795                 800 


Lys Lys Gln Leu Leu Thr Lys Pro Phe Ala Phe Pro Arg Gly Leu Phe 
                805                 810                 815     


Asp Asp Lys Pro Thr Phe Leu Pro Gly Ser Lys Pro Asn Glu Asn Pro 
            820                 825                 830         


Glu Arg Phe Ala Ala Trp Tyr Ser Tyr Gly Tyr Thr Tyr Ser Gly Lys 
        835                 840                 845             


Phe Gln Ser Phe Tyr Asp Met Pro Arg Asn Tyr Ser Asp Trp Tyr Lys 
    850                 855                 860                 


Lys Leu Lys Glu Asp Gly Lys Leu Pro Arg Leu Asp Lys Lys Thr Glu 
865                 870                 875                 880 


Gln Glu Lys Ile Leu Arg Phe Arg Met Asp Cys Asp Leu Asn Ile Lys 
                885                 890                 895     


His Ile Arg Phe Gln Asp Ile Tyr Val Lys Leu Met Val Asp Ser Leu 
            900                 905                 910         


Tyr Lys Ala Val Phe Gly Gln Gln Pro Glu Phe Asp Leu Ser His Leu 
        915                 920                 925             


Tyr Asp Thr Arg Ser Glu Arg Tyr Glu Asn Asn Thr Ile Ala Gln Arg 
    930                 935                 940                 


Gln Lys Ser Arg Gln Glu Gly Asp Asn Ser Asp Asn Ala Ile Asn Glu 
945                 950                 955                 960 


Asn Tyr Val Trp Asn Lys Thr Phe Ala Ile Ser Leu Tyr Asn Gly Arg 
                965                 970                 975     


Ile Thr Glu Ser Gln Val Lys Leu Lys Asp Val Gly Lys Phe Arg Arg 
            980                 985                 990         


Phe Ala Thr Asp Pro Arg Val Gln  Thr Leu Ile Ser Tyr  Asp Asp Thr 
        995                 1000                 1005             


Arg Thr  Trp Thr Lys Leu Glu  Ile Glu Asn Glu Leu  Asp Asn Lys 
    1010                 1015                 1020             


Ala Asp  Ala Tyr Glu Pro Ile  Arg Arg Thr Gln Ser  Leu Lys Ala 
    1025                 1030                 1035             


Ile Gln  Gln Leu Glu Lys Asn  Ile Leu Lys Lys Asn  Gly Phe Asn 
    1040                 1045                 1050             


Gly Lys  Gln His Pro Glu Glu  Leu Lys His Asn Gly  Asn Pro Asn 
    1055                 1060                 1065             


Phe Arg  Lys Tyr Ile Ala Asn  Gly Leu Leu Lys His  Arg Thr Asp 
    1070                 1075                 1080             


Ile Arg  Gln Glu Glu Leu Ala  Leu Ile Ser Asp Thr  Glu Phe Gln 
    1085                 1090                 1095             


Glu Ile  Gly Leu Glu Arg Ile  Arg Gln Thr Asn Pro  Leu Ile Gln 
    1100                 1105                 1110             


Lys Ala  Tyr Leu Leu Ile Leu  Leu Arg Asn Lys Phe  Gly His Asn 
    1115                 1120                 1125             


Gln Leu  Pro Asp Gln Glu His  Phe Arg Leu Met Arg  Ser Ile Tyr 
    1130                 1135                 1140             


Pro Tyr  Asn Gln Gln Glu Ser  Tyr Ser Ala Tyr Phe  Asn His Val 
    1145                 1150                 1155             


Ile Thr  Gln Ile Ile Glu Glu  Leu Asn Thr 
    1160                 1165             


<210>  1692
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1692

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1693
<211>  1102
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1693

Met Glu Asn Lys Glu Lys Pro Glu Pro Ile Tyr Tyr Glu Leu Thr Asp 
1               5                   10                  15      


Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val Tyr 
            20                  25                  30          


Thr Thr Ile Asn His Ile Asn Arg Arg Leu Glu Ile Ala Glu Leu Lys 
        35                  40                  45              


Asp Asp Gly Tyr Met Met Gly Ile Lys Gly Ser Trp Asn Glu Gln Ala 
    50                  55                  60                  


Lys Lys Leu Asp Lys Lys Val Arg Leu Arg Asp Leu Ile Met Lys His 
65                  70                  75                  80  


Phe Pro Phe Leu Glu Ala Ala Ala Tyr Glu Met Thr Asn Ser Lys Ser 
                85                  90                  95      


Pro Asn Asn Lys Glu Gln Arg Glu Lys Glu Gln Ser Glu Ala Leu Ser 
            100                 105                 110         


Leu Asn Asn Leu Lys Asn Val Leu Phe Ile Phe Leu Glu Lys Leu Gln 
        115                 120                 125             


Val Leu Arg Asn Tyr Tyr Ser His Tyr Lys Tyr Ser Glu Glu Ser Pro 
    130                 135                 140                 


Lys Pro Ile Phe Glu Thr Ser Leu Leu Lys Asn Met Tyr Lys Ile Phe 
145                 150                 155                 160 


Asp Thr Asn Val Arg Leu Val Lys Arg Asp Tyr Met His His Glu Asn 
                165                 170                 175     


Val Asp Met Gln Arg Asp Phe Ser His Leu Asn Arg Lys Lys Gln Glu 
            180                 185                 190         


Gly Gln Thr Arg Lys Ile Ile Ala Asn Pro Asn Phe Arg Tyr His Phe 
        195                 200                 205             


Ala Asp Glu Lys Gly Asp Met Thr Ile Ala Gly Leu Leu Phe Phe Ile 
    210                 215                 220                 


Ser Leu Phe Leu Asp Lys Lys Asp Ala Ile Trp Met Gln Lys Lys Leu 
225                 230                 235                 240 


Lys Gly Phe Lys Asp Gly Arg Asn Leu Arg Glu Gln Met Thr Asn Glu 
                245                 250                 255     


Val Phe Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Asn 
            260                 265                 270         


Val Gln Thr Lys Asp Trp Met Gln Leu Asp Met Leu Asn Glu Leu Val 
        275                 280                 285             


Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Arg Glu Lys Asp Arg Glu 
    290                 295                 300                 


Ser Phe Lys Val Pro Phe Asp Ile Phe Ser Asp Asp Tyr Asp Ala Glu 
305                 310                 315                 320 


Glu Glu Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe Pro 
                325                 330                 335     


Tyr Phe Val Leu Arg Tyr Phe Asp Leu Asn Glu Ile Phe Glu Gln Leu 
            340                 345                 350         


Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile Tyr Asn Lys 
        355                 360                 365             


Arg Ile Gly Asp Glu Asp Glu Val Arg His Leu Thr His His Leu Tyr 
    370                 375                 380                 


Gly Phe Ala Arg Ile Gln Asp Phe Ala Pro Gln Asn Gln Pro Glu Glu 
385                 390                 395                 400 


Trp Arg Lys Leu Val Lys Asp Leu Asp His Phe Glu Thr Ser Gln Lys 
                405                 410                 415     


Pro Tyr Ile Ser Lys Thr Ala Pro His Tyr His Leu Glu Asn Glu Lys 
            420                 425                 430         


Ile Gly Ile Lys Phe Cys Ser Thr His Asn Asn Leu Phe Pro Ser Leu 
        435                 440                 445             


Lys Arg Glu Lys Thr Cys Asn Gly Arg Ser Lys Phe Asn Leu Gly Thr 
    450                 455                 460                 


Gln Phe Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Leu Pro Met 
465                 470                 475                 480 


Met Phe Tyr Tyr Leu Leu Leu Thr Lys Asp Tyr Ser Arg Lys Glu Ser 
                485                 490                 495     


Ala Asp Lys Val Glu Gly Ile Ile Arg Lys Glu Ile Ser Asn Ile Tyr 
            500                 505                 510         


Ala Ile Tyr Asp Ala Phe Ala Asn Asn Glu Ile Asn Ser Ile Ala Asp 
        515                 520                 525             


Leu Thr Cys Arg Leu Gln Lys Thr Asn Ile Leu Gln Gly His Leu Pro 
    530                 535                 540                 


Lys Gln Met Ile Ser Ile Leu Glu Gly Arg Gln Lys Asp Met Glu Lys 
545                 550                 555                 560 


Glu Ala Glu Arg Lys Ile Gly Glu Met Ile Asp Asp Thr Gln Arg Arg 
                565                 570                 575     


Leu Asp Leu Leu Cys Lys Gln Thr Asn Gln Lys Ile Arg Ile Gly Lys 
            580                 585                 590         


Arg Asn Ala Gly Leu Leu Lys Ser Gly Lys Ile Ala Asp Trp Leu Val 
        595                 600                 605             


Ser Asp Met Met Arg Phe Gln Pro Val Gln Lys Asp Thr Asn Asn Ala 
    610                 615                 620                 


Pro Ile Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu Gln 
625                 630                 635                 640 


His Ala Leu Ala Leu Phe Gly Ser Glu Ser Ser Arg Leu Lys Ala Tyr 
                645                 650                 655     


Phe Arg Gln Met Asn Leu Val Gly Asn Ala Asn Pro His Pro Phe Leu 
            660                 665                 670         


Ala Glu Thr Gln Trp Glu His Gln Thr Asn Ile Leu Ser Phe Tyr Arg 
        675                 680                 685             


Asn Tyr Leu Glu Ala Arg Lys Lys Tyr Leu Lys Gly Leu Lys Pro Gln 
    690                 695                 700                 


Asn Trp Lys Gln Tyr Gln His Phe Leu Ile Leu Lys Val Gln Lys Thr 
705                 710                 715                 720 


Asn Arg Asn Thr Leu Val Thr Gly Trp Lys Asn Ser Phe Asn Leu Pro 
                725                 730                 735     


Arg Gly Ile Phe Thr Lys Pro Ile Arg Glu Trp Phe Glu Lys His Asn 
            740                 745                 750         


Asn Ser Lys Arg Ile Tyr Asp Gln Ile Leu Ser Phe Gly Arg Val Gly 
        755                 760                 765             


Phe Val Ala Lys Ala Ile Pro Leu Tyr Phe Ala Glu Glu Cys Lys Asp 
    770                 775                 780                 


Cys Val Gln Pro Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Lys Leu 
785                 790                 795                 800 


Lys Pro Lys Lys Gly Gln Phe Leu Asp Lys Lys Asp Arg Val Glu Leu 
                805                 810                 815     


Trp Gln Lys Asn Lys Glu Leu Phe Lys Asn Tyr Pro Pro Glu Lys Arg 
            820                 825                 830         


Lys Thr Asp Leu Ala Tyr Leu Asp Phe Leu Ser Trp Lys Lys Phe Glu 
        835                 840                 845             


Arg Glu Leu Arg Leu Ile Lys Asn Gln Asp Ile Val Thr Trp Leu Met 
    850                 855                 860                 


Phe Lys Glu Leu Phe Lys Thr Thr Thr Val Glu Gly Leu Lys Ile Gly 
865                 870                 875                 880 


Glu Ile His Leu Arg Asp Ile Asp Thr Asn Thr Ala Asn Glu Glu Ser 
                885                 890                 895     


Asn Asn Ile Leu Asn Arg Ile Met Pro Met Lys Leu Pro Val Lys Thr 
            900                 905                 910         


Tyr Glu Thr Asp Asn Lys Gly Asn Ile Leu Lys Glu Arg Pro Leu Ala 
        915                 920                 925             


Thr Phe Tyr Ile Glu Glu Thr Glu Thr Lys Val Leu Lys Gln Gly Asn 
    930                 935                 940                 


Phe Lys Val Leu Ala Lys Asp Arg Arg Leu Asn Gly Leu Leu Ser Phe 
945                 950                 955                 960 


Ala Glu Thr Thr Asp Ile Asp Leu Glu Lys Asn Pro Ile Thr Lys Leu 
                965                 970                 975     


Ser Val Asp His Glu Leu Ile Lys Tyr Gln Thr Thr Arg Ile Ser Ile 
            980                 985                 990         


Phe Glu Met Thr Leu Gly Leu Glu  Lys Lys Leu Ile Asp  Lys Tyr Ser 
        995                 1000                 1005             


Thr Leu  Pro Thr Asp Ser Phe  Arg Asn Met Leu Glu  Arg Trp Leu 
    1010                 1015                 1020             


Gln Cys  Lys Ala Asn Arg Pro  Glu Leu Lys Asn Tyr  Val Asn Ser 
    1025                 1030                 1035             


Leu Ile  Ala Val Arg Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met 
    1040                 1045                 1050             


Tyr Asp  Ala Thr Leu Phe Ala  Glu Val Lys Lys Phe  Thr Leu Phe 
    1055                 1060                 1065             


Pro Ser  Val Asp Thr Lys Lys  Ile Glu Leu Asn Ile  Ala Pro Gln 
    1070                 1075                 1080             


Leu Leu  Glu Ile Val Gly Lys  Ala Ile Lys Glu Ile  Glu Lys Ser 
    1085                 1090                 1095             


Glu Asn  Lys Asn 
    1100         


<210>  1694
<211>  1181
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1694

Met Glu Asn Leu Pro Leu Arg Ser Phe Lys Arg Phe Phe Asp Phe Lys 
1               5                   10                  15      


Gly Asn Val Ala Pro Ile Ala Glu Lys Ala Val Arg Asn Phe Thr Leu 
            20                  25                  30          


Lys Lys Glu Asn Pro Asp Asn Leu Lys Gln Arg Leu His Tyr Phe Ala 
        35                  40                  45              


Ile Gly His Thr Phe Lys Asn Ile Asp Thr Lys Asn Ile Phe Glu Tyr 
    50                  55                  60                  


Thr Leu Asn Glu Glu Thr Arg Glu Ser Met Pro Thr Lys Phe Leu Ala 
65                  70                  75                  80  


Leu Gln Gln Asp Asn Phe Thr Ile Asp Lys Asp Leu Glu Lys Leu Pro 
                85                  90                  95      


Ser Asn Ile Arg Asn Lys Asp Leu Gly Ser Leu Leu Ser Asp Ile Arg 
            100                 105                 110         


Asn Ile Asn Ser His Tyr Val His Asp Phe Glu Lys Leu Lys Leu Asp 
        115                 120                 125             


Asn Ile Asp Asp Lys Ile Ile Glu Phe Leu Lys Gln Ser Phe Glu Leu 
    130                 135                 140                 


Ala Leu Ile Asn Thr Ile Leu Lys Glu Lys Glu Ile Ser Tyr Glu Asp 
145                 150                 155                 160 


Phe Ile Ser Asn Glu Ser Glu Lys Glu Ile Val Asp Phe Leu Val Asp 
                165                 170                 175     


Lys Phe Tyr Pro Leu Asn Asp Gln Arg Lys Asp Leu Asp Glu Leu Ala 
            180                 185                 190         


Gln Lys Ser Leu Asp Asn Tyr Ile Glu Phe Arg Asp Asp Phe Lys Asn 
        195                 200                 205             


Lys Thr Lys Asp Asp Ala Ile Asn Ala Ile Leu Phe Val Asn Val Glu 
    210                 215                 220                 


Thr Glu Tyr Glu Trp Lys Ile Tyr Gly Glu His His Ile Phe Asn Ile 
225                 230                 235                 240 


Thr Lys Gly Ser Tyr Leu Ser Phe Glu Ala Cys Leu Phe Leu Leu Ser 
                245                 250                 255     


Met Phe Leu Tyr Lys Gly Glu Ala Asn Thr Leu Ile Ser Lys Ile Lys 
            260                 265                 270         


Gly Phe Lys Arg Asn Asp Asp Asn Lys Tyr Arg Ser Lys Arg Asn Leu 
        275                 280                 285             


Phe Ser Phe Tyr Ser Lys Lys Phe Ser Ser Gln Asp Ile Asn Ser Glu 
    290                 295                 300                 


Glu Asn His Leu Ile Lys Phe Arg Asp Ile Val Gln Tyr Leu Asn His 
305                 310                 315                 320 


Tyr Pro Thr Ile Trp Asn Lys Asp Leu Glu Leu Glu Ser Asn Asn Pro 
                325                 330                 335     


Leu Met Thr Asp Lys Leu Lys Glu Lys Ile Ile Glu Met Glu Val Ala 
            340                 345                 350         


Arg Cys Phe Pro Asp Leu Asn Ser Asp Ile Glu Phe Asn Glu Phe Ala 
        355                 360                 365             


Ile Gln Tyr Leu Phe Tyr Lys Lys Glu Ser Glu Asn His Asn Lys Asn 
    370                 375                 380                 


Leu Tyr Leu Asp Ile Ile Asn Lys Asn Asp Glu Val Arg Lys Ile Tyr 
385                 390                 395                 400 


Tyr Ser Ile Lys Asn Asp Ser Leu Asn Leu Arg Glu Phe Lys Asp Asn 
                405                 410                 415     


Thr Phe Lys Met Tyr Ala Leu Lys Tyr Val Val Asn Lys Tyr Phe Lys 
            420                 425                 430         


Asp Asn Lys Lys Leu Thr Asn Leu Lys His Lys Arg Phe Tyr Gly Lys 
        435                 440                 445             


Lys Glu Arg Glu Phe Lys Asp Glu Leu Ile Thr Asn Asn Lys Thr Glu 
    450                 455                 460                 


Lys Leu Lys Ile Gln Ile Ser Lys Asn Lys Leu Phe Val Ser Tyr Gly 
465                 470                 475                 480 


Arg Asn Gln Glu Arg Phe Ile Asp Phe Ala Met Cys Phe Leu Ala Lys 
                485                 490                 495     


Thr Asn Tyr Phe Gly Lys Asp Ala Glu Phe Lys Ile Tyr Gln Phe Tyr 
            500                 505                 510         


Ser Ser Glu Glu Gln Asn Glu Glu Leu Asn Thr Leu Lys Gln Lys Leu 
        515                 520                 525             


Thr Lys Lys Gln Tyr Asp Lys Leu Lys Tyr His Arg Gly Lys Leu Val 
    530                 535                 540                 


His Phe Ser Thr Phe Glu Asn His Leu Gly Lys Tyr Asp Asn Trp Asp 
545                 550                 555                 560 


Thr Pro Phe Val Ile Glu Asn Asn Ala Val Gln Val Arg Val Thr Phe 
                565                 570                 575     


Leu Ser Gly Ile Gln Lys Ile Val Ser Ile Gln Arg Asn Leu Leu Thr 
            580                 585                 590         


Tyr Phe Leu Glu Asp Ala Leu Phe Asn Tyr Ser Thr Asn Lys Leu Glu 
        595                 600                 605             


Asp Ala Gly Lys Arg Leu Ile Ser Gly Tyr Phe Thr His His Leu Lys 
    610                 615                 620                 


Glu Phe Ser Glu Ser Lys Leu Ile Leu Glu Gln Lys Thr Ser Ile Ser 
625                 630                 635                 640 


Gln Asp Glu Lys Thr Ser Leu Lys Lys Ile Leu Pro Lys Arg Leu Leu 
                645                 650                 655     


His His Tyr Ser Pro Ala Ile Gln Asn Phe Ile Pro Lys Phe Ser Thr 
            660                 665                 670         


Phe Glu Leu Leu Leu Glu Lys Val Lys Ile Gln Glu Asn Arg Tyr Leu 
        675                 680                 685             


Glu Leu Phe Lys Lys Val Glu Gly Glu Glu Met Ile Tyr Lys Lys Ser 
    690                 695                 700                 


Asn Pro His Asp Lys Asn Val Ser Leu Val Lys Asp Phe Leu Lys Arg 
705                 710                 715                 720 


Asn Lys Gly Arg Gln Phe Lys Leu Asn Phe Ile Arg Lys Ala Cys His 
                725                 730                 735     


Leu Met Tyr Phe Lys Glu Ser Tyr Leu Lys Gln Val Glu Val Ser Gly 
            740                 745                 750         


His His Lys Arg Phe His Ile Ser Lys Asp Glu Phe Asn Asp Phe Ser 
        755                 760                 765             


Lys Trp Met Phe Ala Phe Asp Glu Val Pro Ala Tyr Lys Leu Tyr Leu 
    770                 775                 780                 


Ala Glu Leu Phe Glu Ser Lys Gly Phe Phe Asp Asn Pro Glu Phe Lys 
785                 790                 795                 800 


Ser Leu Phe Glu Ser Ser Thr Ser Leu Ser Asn Met Tyr Glu Asn Thr 
                805                 810                 815     


Lys Asp Val Tyr Glu Asn Trp Leu Leu Thr Leu Lys Gln Ser Glu Lys 
            820                 825                 830         


Asp Lys Asp Lys Tyr Lys Leu Ser Asn Tyr Glu Lys Phe Phe Ala Asp 
        835                 840                 845             


Asp Leu Phe Tyr Ile Asn Val Ser His Phe Leu Lys Tyr Leu Glu Ser 
    850                 855                 860                 


Thr Cys Val Ile Ala Arg Asn Glu Gln Gly Asn Ile Ile Tyr Lys Ser 
865                 870                 875                 880 


Leu Glu Asn Glu Lys His Leu Ile Leu Gly Tyr Tyr Tyr Lys Asn Lys 
                885                 890                 895     


Leu Glu Lys Ala Glu Tyr Lys Thr Cys Gly Lys Leu Tyr Asn Lys Leu 
            900                 905                 910         


Lys Ser Ile Lys Leu Glu Asp Ala Leu Leu Phe Glu Leu Ala Met Tyr 
        915                 920                 925             


Tyr Leu Lys Ile Asp Lys Ser Ile Ser Gln Lys Ala Arg Thr Asp Ile 
    930                 935                 940                 


Thr Thr Leu Leu Ser Gln Asp Val Ile Phe Glu Ile Lys Asp Ser Asn 
945                 950                 955                 960 


Ser Asn His Leu Phe Asp Ile Glu Ile Pro Phe Asn Lys Ile Asp Ala 
                965                 970                 975     


Tyr Val Glu Leu Ile Thr Phe Lys Glu Glu Gln Glu Asp Asp Pro Arg 
            980                 985                 990         


Phe Ser Lys Thr Ser Phe Ile Gly  Asn Leu Pro Ala Tyr  Ile Glu Lys 
        995                 1000                 1005             


Val Lys  Asp Asn Lys Asp Ile  Gln Gln Val Tyr Tyr  Asn Tyr Asn 
    1010                 1015                 1020             


Thr Thr  Lys Asn Leu Thr Tyr  Asp Asp Leu Tyr Thr  Ile Asn Asn 
    1025                 1030                 1035             


His Ile  Ile Ser Asn Ser Val  Lys Phe Thr Lys Val  Ala Leu Leu 
    1040                 1045                 1050             


Leu Glu  Lys Tyr Phe Ile Trp  Lys Asp Glu Ile Lys  Ile Lys Asn 
    1055                 1060                 1065             


Gly Tyr  Asn Ile Asp Phe Glu  Asn Val Ile Gly Leu  Lys Asn Tyr 
    1070                 1075                 1080             


Phe Asp  Lys Glu Lys Lys Lys  Asn Glu Ile Ile Arg  Asn Lys Ala 
    1085                 1090                 1095             


Phe His  Phe Gly Val Pro Asp  Lys Ser Tyr Asp Val  Ile Ile Lys 
    1100                 1105                 1110             


Glu Ile  Glu Gln Lys Phe Ile  Lys Glu Glu Val Lys  Pro Thr Thr 
    1115                 1120                 1125             


Pro Ser  Asn Tyr His Asp Leu  Ser Lys Gln Leu Lys  Trp Ile Cys 
    1130                 1135                 1140             


Lys Ala  Phe Leu Asp Thr Ile  His Asn Asp Tyr Phe  Val Asn Gly 
    1145                 1150                 1155             


Lys Gly  Asp Lys Ser Lys Lys  Arg Ala Asp Ala Glu  Asn Lys Tyr 
    1160                 1165                 1170             


Phe Tyr  Lys Val Ile Asn Lys  Thr 
    1175                 1180     


<210>  1695
<211>  1140
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1695

Met Asn Leu Ser Ile Lys Pro Asn Tyr Arg Lys Tyr Asn Asp Glu Thr 
1               5                   10                  15      


Asp Lys Ala Phe Phe Ala Ser Tyr Leu Asn Thr Ala Lys Gln Asn Val 
            20                  25                  30          


Phe Ile Thr Phe Arg Asp Ile Ser Glu Arg Leu Gly Leu Gly Phe Asp 
        35                  40                  45              


Leu Asn Asp Asp Asp Asn Met Met Asn Ala Gly Leu Trp Lys Lys Leu 
    50                  55                  60                  


Arg Asp Asn Ala Glu Pro Asp Val Ser Trp Lys Ile Ile Gln Lys Ile 
65                  70                  75                  80  


Glu Glu Lys Phe Pro Tyr Ala Asn Tyr Leu Ala Lys Asn Tyr Ala Tyr 
                85                  90                  95      


Phe Lys Arg Lys Glu Arg Gln Ala Lys Pro Glu Asp Tyr Ser Lys Val 
            100                 105                 110         


Phe Ala Ile Phe Ile Gln Gln Leu Tyr Asp Phe Arg Asn Ser Tyr Thr 
        115                 120                 125             


His Ala Val His Asp Pro Val Glu Thr Pro Lys Glu Ile Ile Ala Gly 
    130                 135                 140                 


Met Gln Leu Leu Phe Asp Ala Gly Arg Arg Gly Ile Lys Lys Arg Phe 
145                 150                 155                 160 


Lys Leu Gly Ala Lys Asp Met Met His Leu Val Arg Leu Glu Arg Thr 
                165                 170                 175     


Gly Lys Gly Lys Asp Ala Lys Thr Ile Glu Arg Ser Asp Phe His Tyr 
            180                 185                 190         


Ser Phe Val Asp Asp Lys Asp Lys Leu Ser Glu Lys Gly Leu Ala Tyr 
        195                 200                 205             


Phe Ile Cys Leu Trp Leu Gln Arg Lys Asp Ala Gln Thr Phe Leu Lys 
    210                 215                 220                 


Lys Leu Glu Gly Phe Lys Arg Ser Glu Lys Pro Gly Glu Lys Ala Thr 
225                 230                 235                 240 


Leu Glu Thr Tyr Thr Phe Tyr Ser Leu Arg Leu Pro Gln Pro Lys Leu 
                245                 250                 255     


Lys Ser Asp Asn Asn Ser Ala Gly Leu Leu Leu Asp Met Val Asn Glu 
            260                 265                 270         


Leu Arg Arg Cys Pro Lys His Leu Tyr Pro Leu Leu Ser Glu Asp Asp 
        275                 280                 285             


Lys Glu Arg Phe Leu Lys Lys Ala Glu Glu Ile Glu Thr Glu Asp Glu 
    290                 295                 300                 


Tyr Glu Ala Leu Pro Ile Leu Lys Arg Ser Ser Asn Arg Phe Tyr Tyr 
305                 310                 315                 320 


Phe Ala Leu Lys Tyr Phe Asp Thr Val Phe Lys Asp Ala Lys Phe His 
                325                 330                 335     


Val Asp Leu Gly Asn Tyr Cys Phe His Val Tyr Asn Lys Asp Val Asp 
            340                 345                 350         


Gly Gln Asn Arg Ile Arg Arg Trp Ile Lys Lys Met Thr Ala Phe Gly 
        355                 360                 365             


Asn Leu Asp Asp Phe Ser Asp Glu Lys Arg Pro Gln Gln Trp Ile Asp 
    370                 375                 380                 


Lys Ile Gln Arg Ile Glu Asp Arg Asp Phe Glu Lys Glu Asp Ile Tyr 
385                 390                 395                 400 


Leu Thr Gln Thr Thr Pro His Tyr His Ile Asn Gly Lys Asn Ile Gly 
                405                 410                 415     


Leu Lys Phe Arg His Ser Tyr Ser Glu Leu Val Lys Asp Asn Lys Ile 
            420                 425                 430         


Trp Pro Glu Leu Pro Asp Phe Asp Lys Glu His Ala Lys Thr Thr Leu 
        435                 440                 445             


Pro Arg Thr Lys Ala Pro Asp Cys Trp Leu Ser Leu Tyr Glu Leu Pro 
    450                 455                 460                 


Ala Met Val Phe Tyr His Leu Leu Leu Gln Asp Asn Thr Ala Ser Thr 
465                 470                 475                 480 


Ser Val Glu Glu Ile Ile Arg Leu His Val Lys Ser Met Asp Leu Phe 
                485                 490                 495     


Phe Met Asp Ile Glu Asn Gly Val Leu Asn Pro Gly Met Asn Asn Ser 
            500                 505                 510         


Gly Phe Ala Glu Glu Ile Ser Lys Arg Gly Leu Glu Lys Tyr Phe Ile 
        515                 520                 525             


Pro Lys Pro Leu Ile Glu Tyr Leu Thr Ser Ala Thr Thr Lys Thr Phe 
    530                 535                 540                 


Glu Asp Arg Ala Asp Lys Met Leu Glu Ala Leu Ile Ala Glu Thr Lys 
545                 550                 555                 560 


Gln Met Leu Lys Lys Ile Asn Asn Gln Lys Asp Asn Phe Ala Gln Lys 
                565                 570                 575     


Pro Gly Ser Lys Asp Tyr Val Glu Met Lys Ser Gly Asn Met Ala Asp 
            580                 585                 590         


Phe Leu Ala Arg Asp Ile Ile Arg Leu Gln Lys Pro Leu Ala Gly Met 
        595                 600                 605             


Lys Gly Lys Pro Asn Ser Thr Glu Phe Gln Val Leu Gln Ala Lys Leu 
    610                 615                 620                 


Ala Phe Phe Gly Ala Asn Lys Asp Ser Leu Asp Ala Thr Phe Asn Asn 
625                 630                 635                 640 


Leu Gln Leu Thr Asn Ser Glu Asn Pro His Pro Phe Leu His Gln Ile 
                645                 650                 655     


Arg Val Asp Thr Cys Lys Gly Ile Leu Asp Phe Tyr Val Lys Tyr Leu 
            660                 665                 670         


Lys Lys Arg Glu Trp Tyr Leu Gly Tyr Cys Lys Ser Lys Glu Gln Tyr 
        675                 680                 685             


His Asp Tyr His Phe Leu Lys Met Gly Arg Arg Arg Lys Glu His Ser 
    690                 695                 700                 


Glu Thr Tyr Tyr Lys Asn Leu Ala Asn Glu Leu Arg Thr Gln Asn Val 
705                 710                 715                 720 


Gln Asn Leu Pro Arg Gly Leu Phe Leu Lys Pro Ile Leu Asn Ile Leu 
                725                 730                 735     


Ser Ser Thr Glu Lys Thr Lys Val Leu Ala Gly Glu Leu Lys Gln Leu 
            740                 745                 750         


Ser Arg Val Asn Thr Ala Tyr Ile Ile Glu Lys Tyr Phe Thr Gln Ile 
        755                 760                 765             


Leu Asp Asp Ser Pro Gln Glu Phe Tyr Thr Tyr Asn Arg Ser Tyr Glu 
    770                 775                 780                 


Phe Leu Asn Lys Ile Tyr Asp Asp Arg Lys Lys Asn Gly Met Pro Leu 
785                 790                 795                 800 


Lys Gln Lys Phe Leu Thr Ile Asp Glu Leu Lys Asp Lys Ala Gln Arg 
                805                 810                 815     


Ile Asn Glu Asp Thr Tyr Asp Asn Glu Ile Leu Arg Ala Met Asp Asp 
            820                 825                 830         


Lys Ile Glu Val Glu Ala Lys Lys Thr Lys Arg Asn Gly Lys Arg Leu 
        835                 840                 845             


Ser Lys Asp Glu Ile Asn Glu Leu Lys Glu Lys Tyr Trp Thr Arg Tyr 
    850                 855                 860                 


Lys Ala Phe Gly Glu Asn Glu Lys Gln Ile Arg Leu Ala Lys Thr Cys 
865                 870                 875                 880 


Asp Met Val Leu Phe Met Leu Val Asp His Thr Leu Arg Arg Ser Phe 
                885                 890                 895     


Val Ile Asn Glu Gly Phe Val Lys Lys Lys Lys Glu Thr Asn Asp Ile 
            900                 905                 910         


Lys Pro Val Glu Phe Gly Asn Glu Tyr Lys Leu Ser Gln Ile Lys Ala 
        915                 920                 925             


Glu Ser Asp Lys Gly Ile Leu Glu Leu Gln Thr Glu Ala Lys Ile Glu 
    930                 935                 940                 


Met Pro Tyr Ser Tyr Glu Thr Asn Met Asp Ser Leu Leu Lys Ile Ala 
945                 950                 955                 960 


Gly Ala Lys Ser Lys Leu Ser Asp Leu Gln Ser Lys Thr Ile Leu Arg 
                965                 970                 975     


Glu Gln Ile Lys Ile Lys Asn Tyr Gly Asp Phe Arg Ala Leu Met Lys 
            980                 985                 990         


Asp Arg Arg Ile Ser Ser Leu Leu  Pro Tyr Leu Ala Lys  Asp Pro Ile 
        995                 1000                 1005             


Tyr Phe  Glu Ala Leu Gln Lys  Glu Leu Glu Leu Tyr  Gln Glu Val 
    1010                 1015                 1020             


Arg Val  Glu Val Met Asp Thr  Ile His Asn Phe Glu  Arg Lys Ala 
    1025                 1030                 1035             


Ile Ala  Leu Lys Gly Ile Ile  Lys Gly Ser Asp Lys  Ala Phe Ile 
    1040                 1045                 1050             


Ser His  Glu Gln Ile Leu Asp  Gly Phe Pro Gly Tyr  Asp Pro Ala 
    1055                 1060                 1065             


Lys Arg  Met Lys Ile Glu Lys  Leu Arg Asn Ala Phe  Cys His Ser 
    1070                 1075                 1080             


Gln Tyr  Pro Ala Tyr Leu Leu  Tyr Lys Asp Glu Ile  Asn Gly Asp 
    1085                 1090                 1095             


Gly Ile  Asn Lys Leu Lys Asp  Tyr Thr Ala Asp Glu  Pro Ile Val 
    1100                 1105                 1110             


Leu His  Asn Ser Pro Ala Leu  Gln Phe Lys Lys Ile  Ile Gln Lys 
    1115                 1120                 1125             


Tyr Tyr  Asp Asp Ile Ile Gln  Phe Asp Ile Thr Gly  
    1130                 1135                 1140 


<210>  1696
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1696

Leu Gln Lys Gln Asp Lys Leu Phe Val Asp Arg Lys Lys Asn Ala Ile 
1               5                   10                  15      


Phe Ala Phe Pro Lys Tyr Ile Thr Ile Met Glu Asn Lys Glu Lys Pro 
            20                  25                  30          


Glu Pro Ile Tyr Tyr Glu Leu Thr Asp Lys His Phe Trp Ala Ala Phe 
        35                  40                  45              


Leu Asn Leu Ala Arg His Asn Val Tyr Thr Thr Ile Asn His Ile Asn 
    50                  55                  60                  


Arg Arg Leu Glu Ile Ala Glu Leu Lys Asp Asp Gly Tyr Met Met Asp 
65                  70                  75                  80  


Ile Lys Gly Ser Trp Asn Glu Gln Ala Lys Lys Leu Asp Lys Lys Val 
                85                  90                  95      


Arg Leu Arg Asp Leu Ile Met Lys His Phe Pro Phe Leu Glu Ala Ala 
            100                 105                 110         


Ala Tyr Glu Met Thr Asn Ser Lys Ser Pro Asn Asn Lys Glu Gln Arg 
        115                 120                 125             


Glu Lys Glu Gln Ser Glu Ala Leu Ser Leu Asn Asn Leu Lys Asn Val 
    130                 135                 140                 


Leu Phe Ile Phe Leu Glu Lys Leu Gln Val Leu Arg Asn Tyr Tyr Ser 
145                 150                 155                 160 


His Tyr Lys Tyr Ser Glu Glu Ser Pro Lys Pro Ile Phe Glu Thr Ser 
                165                 170                 175     


Leu Leu Lys Asn Met Tyr Lys Val Phe Asp Ala Asn Val Arg Leu Val 
            180                 185                 190         


Lys Arg Asp Tyr Met His His Glu Asn Ile Asp Met Gln Arg Asp Phe 
        195                 200                 205             


Thr His Leu Asn Arg Lys Lys Gln Val Gly Arg Thr Lys Asn Ile Ile 
    210                 215                 220                 


Asp Ser Pro Asn Phe His Tyr His Phe Ala Asp Lys Glu Gly Asn Met 
225                 230                 235                 240 


Thr Ile Ala Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Asp Lys Lys 
                245                 250                 255     


Asp Ala Ile Trp Met Gln Lys Lys Leu Lys Gly Phe Lys Asp Gly Arg 
            260                 265                 270         


Asn Leu Arg Glu Gln Met Thr Asn Glu Val Phe Cys Arg Ser Arg Ile 
        275                 280                 285             


Ser Leu Pro Lys Leu Lys Leu Glu Asn Val Gln Thr Lys Asp Trp Met 
    290                 295                 300                 


Gln Leu Asp Met Leu Asn Glu Leu Val Arg Cys Pro Lys Ser Leu Tyr 
305                 310                 315                 320 


Glu Arg Leu Arg Glu Lys Asp Arg Glu Ser Phe Lys Val Pro Phe Asp 
                325                 330                 335     


Ile Phe Ser Asp Asp Tyr Asp Ala Glu Glu Glu Pro Phe Lys Asn Thr 
            340                 345                 350         


Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe 
        355                 360                 365             


Asp Leu Asn Glu Ile Phe Glu Gln Leu Arg Phe Gln Ile Asp Leu Gly 
    370                 375                 380                 


Thr Tyr His Phe Ser Ile Tyr Asn Lys Arg Ile Gly Asp Glu Asp Glu 
385                 390                 395                 400 


Val Arg His Leu Thr His His Leu Tyr Gly Phe Ala Arg Ile Gln Asp 
                405                 410                 415     


Phe Ala Pro Gln Asn Gln Pro Glu Glu Trp Arg Lys Leu Val Lys Asp 
            420                 425                 430         


Leu Asp His Phe Glu Thr Ser Gln Glu Pro Tyr Ile Ser Lys Thr Ala 
        435                 440                 445             


Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Lys Phe Cys Ser 
    450                 455                 460                 


Thr His Asn Asn Leu Phe Pro Ser Leu Lys Arg Glu Lys Thr Cys Asn 
465                 470                 475                 480 


Gly Arg Ser Lys Phe Asn Leu Gly Thr Gln Phe Thr Ala Glu Ala Phe 
                485                 490                 495     


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu 
            500                 505                 510         


Thr Lys Asp His Pro Lys Gly Glu Gly Ile Asn Lys Ile Glu Lys Ile 
        515                 520                 525             


Ile Arg Thr Glu Ile Ser Asn Ile Tyr Asp Ile Tyr Asp Ala Phe Ala 
    530                 535                 540                 


Asn Gly Glu Ile Asn Ser Ile Ala Asp Leu Thr Cys Arg Leu Gln Lys 
545                 550                 555                 560 


Thr Asn Ile Leu Gln Gly His Leu Pro Lys Gln Met Ile Ser Ile Leu 
                565                 570                 575     


Glu Gly Arg Gln Lys Asp Met Glu Lys Glu Ala Glu Arg Lys Ile Gly 
            580                 585                 590         


Glu Met Ile Asp Asp Thr Gln Arg Arg Leu Asp Leu Leu Cys Lys Gln 
        595                 600                 605             


Thr Asn Gln Lys Ile Arg Ile Gly Lys Arg Asn Ala Gly Leu Leu Lys 
    610                 615                 620                 


Ser Gly Lys Ile Ala Asp Trp Leu Val Asn Asp Met Met Arg Phe Gln 
625                 630                 635                 640 


Pro Val Gln Lys Asp Gln Asn Asn Ile Pro Ile Asn Asn Ser Lys Ala 
                645                 650                 655     


Asn Ser Thr Glu Tyr Arg Met Leu Gln Arg Ala Leu Ala Leu Phe Gly 
            660                 665                 670         


Ser Glu Asn Phe Arg Leu Lys Ala Tyr Phe Asn Gln Met Asn Leu Val 
        675                 680                 685             


Gly Asn Asp Asn Pro His Pro Phe Leu Ala Glu Thr Gln Trp Glu His 
    690                 695                 700                 


Gln Thr Asn Ile Leu Ser Phe Tyr Arg Asn Tyr Leu Glu Ala Arg Lys 
705                 710                 715                 720 


Lys Tyr Leu Lys Gly Leu Lys Pro Gln Asn Trp Lys Gln Tyr Gln His 
                725                 730                 735     


Phe Leu Ile Leu Lys Val Gln Lys Thr Asn Arg Asn Thr Leu Val Thr 
            740                 745                 750         


Gly Trp Lys Asn Ser Phe Asn Leu Pro Arg Gly Ile Phe Thr Lys Pro 
        755                 760                 765             


Ile Arg Glu Trp Phe Glu Lys His Asn Asn Ser Lys Arg Ile Tyr Asp 
    770                 775                 780                 


Gln Ile Leu Ser Phe Asp Arg Val Gly Phe Val Ala Lys Ala Ile Pro 
785                 790                 795                 800 


Leu Tyr Phe Ala Gly Glu Tyr Lys Asp Asn Val Gln Pro Phe Tyr Asp 
                805                 810                 815     


Tyr Pro Phe Asn Ile Gly Asn Lys Leu Lys Pro Gln Lys Gly Gln Phe 
            820                 825                 830         


Leu Asp Lys Lys Glu Arg Val Glu Leu Trp Gln Lys Asn Lys Glu Leu 
        835                 840                 845             


Phe Lys Asn Tyr Pro Pro Glu Lys Arg Lys Thr Asp Leu Ala Tyr Leu 
    850                 855                 860                 


Asp Phe Leu Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys 
865                 870                 875                 880 


Asn Gln Asp Ile Val Thr Trp Leu Met Phe Lys Glu Leu Phe Lys Thr 
                885                 890                 895     


Thr Thr Val Glu Gly Leu Lys Ile Gly Glu Ile His Leu Arg Asp Ile 
            900                 905                 910         


Asp Thr Asn Thr Ala Asn Glu Glu Ser Asn Asn Ile Leu Asn Arg Ile 
        915                 920                 925             


Met Pro Met Lys Leu Pro Val Lys Thr Tyr Glu Thr Asp Asn Lys Gly 
    930                 935                 940                 


Asn Ile Leu Lys Glu Arg Pro Leu Ala Thr Phe Tyr Ile Glu Glu Thr 
945                 950                 955                 960 


Glu Thr Lys Val Leu Lys Gln Gly Asn Phe Lys Val Leu Ala Lys Asp 
                965                 970                 975     


Arg Arg Leu Asn Gly Leu Leu Ser Phe Ala Glu Thr Thr Asp Ile Asp 
            980                 985                 990         


Leu Glu Lys Asn Pro Ile Thr Lys  Leu Ser Val Asp His  Glu Leu Ile 
        995                 1000                 1005             


Lys Tyr  Gln Thr Thr Arg Ile  Ser Ile Phe Glu Met  Thr Leu Gly 
    1010                 1015                 1020             


Leu Glu  Lys Lys Leu Ile Asp  Lys Tyr Ser Thr Leu  Pro Thr Tyr 
    1025                 1030                 1035             


Ser Phe  Lys Asn Met Leu Glu  Ser Trp Leu Glu Asp  Lys Thr Asn 
    1040                 1045                 1050             


Ser Val  Glu Leu Asn Asn Tyr  Val Asp Cys Leu Ile  Ala Val Arg 
    1055                 1060                 1065             


Asn Ala  Phe Ala His Asn Gln  Tyr Pro Met Tyr Asn  Pro Lys Leu 
    1070                 1075                 1080             


Phe Ala  Glu Val Lys Lys Phe  Ser Leu Phe Pro Ser  Ser Asn Thr 
    1085                 1090                 1095             


Lys Lys  Thr Glu Leu Asn Ile  Ala Ser Gln Leu Leu  Arg Ile Val 
    1100                 1105                 1110             


Glu Lys  Ala Ile Asp Glu Ile  Glu Lys Ser Glu Asn  Lys Asn 
    1115                 1120                 1125         


<210>  1697
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1697

Leu Gln Lys Gln Asp Lys Leu Phe Val Asp Arg Lys Lys Asn Ala Ile 
1               5                   10                  15      


Phe Ala Phe Pro Lys Tyr Ile Thr Ile Met Glu Asn Lys Glu Lys Pro 
            20                  25                  30          


Glu Pro Ile Tyr Tyr Glu Leu Thr Asp Lys His Phe Trp Ala Ala Phe 
        35                  40                  45              


Leu Asn Leu Ala Arg His Asn Val Tyr Thr Thr Ile Asn His Ile Asn 
    50                  55                  60                  


Arg Arg Leu Glu Ile Ala Glu Leu Lys Asp Asp Gly Tyr Met Met Gly 
65                  70                  75                  80  


Ile Lys Gly Ser Trp Asn Glu Gln Ala Lys Lys Leu Asp Lys Lys Val 
                85                  90                  95      


Arg Leu Arg Asp Leu Ile Met Lys His Phe Pro Phe Leu Glu Ala Ala 
            100                 105                 110         


Ala Tyr Glu Met Thr Asn Ser Lys Ser Pro Asn Asn Lys Glu Gln Arg 
        115                 120                 125             


Glu Lys Glu Gln Ser Glu Ala Leu Ser Leu Asn Asn Leu Lys Asn Val 
    130                 135                 140                 


Leu Phe Ile Phe Leu Glu Lys Leu Gln Val Leu Arg Asn Tyr Tyr Ser 
145                 150                 155                 160 


His Tyr Lys Tyr Ser Glu Glu Ser Pro Lys Pro Ile Phe Glu Thr Ser 
                165                 170                 175     


Leu Leu Lys Asn Met Tyr Lys Ile Phe Asp Thr Asn Val Arg Leu Val 
            180                 185                 190         


Lys Arg Asp Tyr Met His His Glu Asn Val Asp Met Gln Arg Asp Phe 
        195                 200                 205             


Ser His Leu Asn Arg Lys Lys Gln Glu Gly Gln Thr Arg Lys Ile Ile 
    210                 215                 220                 


Ala Asn Pro Asn Phe Arg Tyr His Phe Ala Asp Glu Lys Gly Asp Met 
225                 230                 235                 240 


Thr Ile Ala Gly Leu Leu Phe Phe Ile Ser Leu Phe Leu Asp Lys Lys 
                245                 250                 255     


Asp Ala Ile Trp Met Gln Lys Lys Leu Lys Gly Phe Lys Asp Gly Arg 
            260                 265                 270         


Asn Leu Arg Glu Gln Met Thr Asn Glu Val Phe Cys Arg Ser Arg Ile 
        275                 280                 285             


Ser Leu Pro Lys Leu Lys Leu Glu Asn Val Gln Thr Lys Asp Trp Met 
    290                 295                 300                 


Gln Leu Asp Met Leu Asn Glu Leu Val Arg Cys Pro Lys Ser Leu Tyr 
305                 310                 315                 320 


Glu Arg Leu Arg Glu Lys Asp Arg Glu Ser Phe Lys Val Pro Phe Asp 
                325                 330                 335     


Ile Phe Ser Asp Asp Tyr Asp Ala Glu Glu Glu Pro Phe Lys Asn Thr 
            340                 345                 350         


Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe 
        355                 360                 365             


Asp Leu Asn Glu Ile Phe Glu Gln Leu Arg Phe Gln Ile Asp Leu Gly 
    370                 375                 380                 


Thr Tyr His Phe Ser Ile Tyr Asn Lys Arg Ile Gly Asp Glu Asp Glu 
385                 390                 395                 400 


Val Arg His Leu Thr His His Leu Tyr Gly Phe Ala Arg Ile Gln Asp 
                405                 410                 415     


Phe Ala Pro Gln Asn Gln Pro Glu Glu Trp Arg Lys Leu Val Lys Asp 
            420                 425                 430         


Leu Asp His Phe Glu Thr Ser Gln Lys Pro Tyr Ile Ser Lys Thr Ala 
        435                 440                 445             


Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Lys Phe Cys Ser 
    450                 455                 460                 


Thr His Asn Asn Leu Phe Pro Ser Leu Lys Arg Glu Lys Thr Cys Asn 
465                 470                 475                 480 


Gly Arg Ser Lys Phe Asn Leu Gly Thr Gln Phe Thr Ala Glu Ala Phe 
                485                 490                 495     


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu 
            500                 505                 510         


Thr Lys Asp Tyr Ser Arg Lys Glu Ser Ala Asp Lys Val Glu Gly Ile 
        515                 520                 525             


Ile Arg Lys Glu Ile Ser Asn Ile Tyr Ala Ile Tyr Asp Ala Phe Ala 
    530                 535                 540                 


Asn Asn Glu Ile Asn Ser Ile Ala Asp Leu Thr Cys Arg Leu Gln Lys 
545                 550                 555                 560 


Thr Asn Ile Leu Gln Gly His Leu Pro Lys Gln Met Ile Ser Ile Leu 
                565                 570                 575     


Glu Gly Arg Gln Lys Asp Met Glu Lys Glu Ala Glu Arg Lys Ile Gly 
            580                 585                 590         


Glu Met Ile Asp Asp Thr Gln Arg Arg Leu Asp Leu Leu Cys Lys Gln 
        595                 600                 605             


Thr Asn Gln Lys Ile Arg Ile Gly Lys Arg Asn Ala Gly Leu Leu Lys 
    610                 615                 620                 


Ser Gly Lys Ile Ala Asp Trp Leu Val Ser Asp Met Met Arg Phe Gln 
625                 630                 635                 640 


Pro Val Gln Lys Asp Thr Asn Asn Ala Pro Ile Asn Asn Ser Lys Ala 
                645                 650                 655     


Asn Ser Thr Glu Tyr Arg Met Leu Gln His Ala Leu Ala Leu Phe Gly 
            660                 665                 670         


Ser Glu Ser Ser Arg Leu Lys Ala Tyr Phe Arg Gln Met Asn Leu Val 
        675                 680                 685             


Gly Asn Ala Asn Pro His Pro Phe Leu Ala Glu Thr Gln Trp Glu His 
    690                 695                 700                 


Gln Thr Asn Ile Leu Ser Phe Tyr Arg Asn Tyr Leu Glu Ala Arg Lys 
705                 710                 715                 720 


Lys Tyr Leu Lys Gly Leu Lys Pro Gln Asn Trp Lys Gln Tyr Gln His 
                725                 730                 735     


Phe Leu Ile Leu Lys Val Gln Lys Thr Asn Arg Asn Thr Leu Val Thr 
            740                 745                 750         


Gly Trp Lys Asn Ser Phe Asn Leu Pro Arg Gly Ile Phe Thr Lys Pro 
        755                 760                 765             


Ile Arg Glu Trp Phe Glu Lys His Asn Asn Ser Lys Arg Ile Tyr Asp 
    770                 775                 780                 


Gln Ile Leu Ser Phe Gly Arg Val Gly Phe Val Ala Lys Ala Ile Pro 
785                 790                 795                 800 


Leu Tyr Phe Ala Glu Glu Cys Lys Asp Cys Val Gln Pro Phe Tyr Asp 
                805                 810                 815     


Tyr Pro Phe Asn Val Gly Asn Lys Leu Lys Pro Lys Lys Gly Gln Phe 
            820                 825                 830         


Leu Asp Lys Lys Asp Arg Val Glu Leu Trp Gln Lys Asn Lys Glu Leu 
        835                 840                 845             


Phe Lys Asn Tyr Pro Pro Glu Lys Arg Lys Thr Asp Leu Ala Tyr Leu 
    850                 855                 860                 


Asp Phe Leu Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys 
865                 870                 875                 880 


Asn Gln Asp Ile Val Thr Trp Leu Met Phe Lys Glu Leu Phe Lys Thr 
                885                 890                 895     


Thr Thr Val Glu Gly Leu Lys Ile Gly Glu Ile His Leu Arg Asp Ile 
            900                 905                 910         


Asp Thr Asn Thr Ala Asn Glu Glu Ser Asn Asn Ile Leu Asn Arg Ile 
        915                 920                 925             


Met Pro Met Lys Leu Pro Val Lys Thr Tyr Glu Thr Asp Asn Lys Gly 
    930                 935                 940                 


Asn Ile Leu Lys Glu Arg Pro Leu Ala Thr Phe Tyr Ile Glu Glu Thr 
945                 950                 955                 960 


Glu Thr Lys Val Leu Lys Gln Gly Asn Phe Lys Val Leu Ala Lys Asp 
                965                 970                 975     


Arg Arg Leu Asn Gly Leu Leu Ser Phe Ala Glu Thr Thr Asp Ile Asp 
            980                 985                 990         


Leu Glu Lys Asn Pro Ile Thr Lys  Leu Ser Val Asp His  Glu Leu Ile 
        995                 1000                 1005             


Lys Tyr  Gln Thr Thr Arg Ile  Ser Ile Phe Glu Met  Thr Leu Gly 
    1010                 1015                 1020             


Leu Glu  Lys Lys Leu Ile Asp  Lys Tyr Ser Thr Leu  Pro Thr Asp 
    1025                 1030                 1035             


Ser Phe  Arg Asn Met Leu Glu  Arg Trp Leu Gln Cys  Lys Ala Asn 
    1040                 1045                 1050             


Arg Pro  Glu Leu Lys Asn Tyr  Val Asn Ser Leu Ile  Ala Val Arg 
    1055                 1060                 1065             


Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met Tyr Asp  Ala Thr Leu 
    1070                 1075                 1080             


Phe Ala  Glu Val Lys Lys Phe  Thr Leu Phe Pro Ser  Val Asp Thr 
    1085                 1090                 1095             


Lys Lys  Ile Glu Leu Asn Ile  Ala Pro Gln Leu Leu  Glu Ile Val 
    1100                 1105                 1110             


Gly Lys  Ala Ile Lys Glu Ile  Glu Lys Ser Glu Asn  Lys Asn 
    1115                 1120                 1125         


<210>  1698
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1698

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Met Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Met Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1699
<211>  1186
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1699

Val Arg Leu Gln Ile Phe Thr Phe Ile Lys Pro Tyr Met Asn Pro Glu 
1               5                   10                  15      


Asn Asn Ile Val Lys Asn Tyr Ser Val Lys Glu Thr Pro Trp Tyr Phe 
            20                  25                  30          


Gly Ala Tyr Leu Asn Met Ala Arg His Asn Val Tyr Leu Leu Ile Asn 
        35                  40                  45              


His Leu Thr Asp Lys Phe Ser Tyr Leu Lys Asn Tyr Lys Lys Leu Ser 
    50                  55                  60                  


Leu Glu Lys Gln Thr Gly Thr Ser Lys Phe Glu Leu Arg Pro Gln Pro 
65                  70                  75                  80  


Phe Ser Ile Leu Thr Asp Asp Glu Gln Ile Val Asn Glu Asn Ile Leu 
                85                  90                  95      


Thr Lys Ile Phe Asp Thr Ser Tyr Pro Gln Tyr Asp Asn Asp Arg Phe 
            100                 105                 110         


Arg Ile Tyr Lys Tyr Met Val Arg Lys His Ser Leu Pro Phe Ile Lys 
        115                 120                 125             


Asn Phe Ser Glu Thr Gly Gly Arg Asn Leu Asp Asp Asn Pro Ile Ile 
    130                 135                 140                 


Asp Tyr Asp Gly Leu His Gln Tyr Ile Asn Glu Ala Phe Ala Leu Leu 
145                 150                 155                 160 


Val Arg Leu Arg Asp Ser Phe Ser His Tyr Leu Ala Ile Asp Lys Phe 
                165                 170                 175     


Gly Asn Lys Ile Glu Asp Arg Asn Leu Thr Val Ser Thr Asn Ile His 
            180                 185                 190         


Thr Gln Val Ile Asn Leu Tyr Thr Asn Ser Pro Asn Tyr Ser Leu Glu 
        195                 200                 205             


Arg Phe Ser Ala Thr Gln Ser Asp Phe Asp Tyr Glu His Leu Ser Leu 
    210                 215                 220                 


Tyr Lys Ile Phe Glu Ala Asp Asn Ile Thr Phe Thr Glu Gln Gly Leu 
225                 230                 235                 240 


Tyr Phe Phe Ile Asn Leu Phe Leu Glu Arg Gly Tyr Gly Ile Lys Phe 
                245                 250                 255     


Leu Lys Lys Ile Arg Gly Phe Lys Asn Asp Thr Asn Pro Ala Phe Arg 
            260                 265                 270         


Ala Thr Ile Lys Thr Phe Thr Thr Tyr Ala Leu Lys Val Pro Asp Glu 
        275                 280                 285             


Arg Leu Asp Asn Asp Asp Pro Arg Met Ser Leu Leu Met Asp Val Leu 
    290                 295                 300                 


Asn Glu Leu Lys Arg Cys Pro Ala Ile Leu Ser Lys His Leu Ser Asp 
305                 310                 315                 320 


Gln Asp Gln Lys Lys Phe Asn Pro Gln Leu Asn Asp Asp Ser Lys Ala 
                325                 330                 335     


Asn Val Leu Leu Asn Ser Val Asn Tyr Asp Asp Ile Asp Asp Glu Gln 
            340                 345                 350         


Ile Asp Tyr Leu Leu Asn Ser Ile Thr Thr Phe Lys Arg His Gln Asp 
        355                 360                 365             


Arg Phe Pro Tyr Phe Ala Leu Arg Cys Ile Asp Glu Leu Asn Leu Leu 
    370                 375                 380                 


Pro Asn Ile Arg Phe Gln Val Ala Leu Gly Ser Ile Glu Arg Arg Ser 
385                 390                 395                 400 


Tyr Asp Lys Val Val Gly Asp Val Ile Ile Asp Arg Arg Ile Leu Lys 
                405                 410                 415     


Lys Leu Asn Ala Phe Gly Lys Leu Ser Tyr Phe Glu Gly Lys Glu Glu 
            420                 425                 430         


Gln Val Leu Leu Glu Leu Asn Arg Lys Val Lys Asp Gln Asp Leu Leu 
        435                 440                 445             


Phe Asp Gln Phe Asn Pro His Tyr Asn Ile Asn Asn Asn Lys Ile Gly 
    450                 455                 460                 


Phe Tyr Thr Phe Ser Ser Gly Lys Glu Lys Ile Gln Trp Pro Thr Ile 
465                 470                 475                 480 


Ala Asp Phe Pro Lys Glu Gly Asn Leu His Gln Lys Arg Asp Asn Ser 
                485                 490                 495     


Ile Pro Lys Ser Phe Leu Ser Ile His Glu Leu Pro Lys Leu Leu Leu 
            500                 505                 510         


Leu Ala Leu Lys Asp Pro Glu Leu Ala Glu Lys Thr Ile Thr Asp Phe 
        515                 520                 525             


Leu Asp Val Asn Lys Asn Leu Val Leu Asn Lys Ala Ala Leu Gly Gln 
    530                 535                 540                 


Ile Arg Asp Lys Ile Lys Leu Cys Pro Ser Ile Phe Asn Arg Arg Arg 
545                 550                 555                 560 


Val Glu Glu Lys Ala Leu Lys Gln Lys Gly Arg Ile Gln Phe Leu Asn 
                565                 570                 575     


His Ala Gln Ile Lys Asn Leu Arg Gln Arg Asn Lys Ile Thr Asp Glu 
            580                 585                 590         


Arg Leu Ala Asp Leu Lys Phe Met Asp Ser Met Ile Ser Asn Thr Lys 
        595                 600                 605             


Asn Ile Lys Ile Lys Glu Tyr Leu Lys Gln Ile Asn Tyr Asn Gln Val 
    610                 615                 620                 


Leu Glu Thr Arg Lys Asp Ala Leu Arg Gln Val Leu Pro Ala Gly Leu 
625                 630                 635                 640 


Lys Val Asn Gln Leu Pro Thr Ile Val Ile Asp Tyr Leu Leu Gly Met 
                645                 650                 655     


Val Gly Gln Asp Pro His Lys Lys Ile Leu Ala Arg Phe Lys Glu Ile 
            660                 665                 670         


Lys Thr Asp Thr Asn Lys Arg Leu Lys Gln Leu Asp Arg Asp Asp Asp 
        675                 680                 685             


Ser Arg Leu Lys Val Gly Glu Ile Ala Thr Phe Leu Thr Lys Asp Ile 
    690                 695                 700                 


Ile Asn Leu Val Ile Ser Glu Asp Leu Lys Lys Lys Ile Thr Ser Ala 
705                 710                 715                 720 


Tyr Tyr Gly Arg Ile Gln Tyr Gln Phe Ala Asn Phe Ser Ile Ser Lys 
                725                 730                 735     


Gly Glu Leu Thr Thr Ile Ile Glu Gln Leu Gly Leu Phe Asp Asn Ile 
            740                 745                 750         


Lys Gly His Pro Phe Leu Ala Ser Ser Met Leu Asn Lys Val Lys Gly 
        755                 760                 765             


Ile Arg Glu Phe Tyr Asp Asn Tyr Leu Ser Ala Lys Leu Lys Trp Ile 
    770                 775                 780                 


Asn Gly Ile Ile Ala Asn Lys Asn Leu Lys Asp Leu Leu Lys Asn Asn 
785                 790                 795                 800 


Lys Ile Ser Leu Pro Phe Lys Ile Lys Ser Ile Ile Ser Lys Ser Glu 
                805                 810                 815     


Ala Lys Asn Leu Asp Asn Trp Leu Lys Ser Lys Lys Asp Met Pro Val 
            820                 825                 830         


Asp Leu Pro Val Ser Ile Phe Asp Asp Gln Leu Asn Thr Tyr Leu Lys 
        835                 840                 845             


Lys Glu Leu Gln His Val Asn Ile Ala Phe Gln Glu Thr Asp Lys Phe 
    850                 855                 860                 


Ser Val Leu Leu Thr Lys Leu Leu Asn Gly Asp Lys Gln Pro Phe Tyr 
865                 870                 875                 880 


Asn His Thr Arg Trp Tyr Arg Ser Glu Glu Gly Asp Val Pro Phe Ser 
                885                 890                 895     


Pro Asp Gly His Ser Ser Leu Thr Ile Lys Asn Asn Tyr Ser Ser Tyr 
            900                 905                 910         


Ala Glu Leu Thr Glu Lys Lys Ile Arg His Val Gln Thr Gln Asp Arg 
        915                 920                 925             


Val Leu Arg Leu Ala Cys Gln Ser Ile Leu Gly Gln Leu Ser Asp Val 
    930                 935                 940                 


Asp Asp Thr Leu Thr Phe Tyr Leu Gln Asp Ile Leu Ala Phe Thr Asn 
945                 950                 955                 960 


Thr Asn Pro Leu Asn Arg Pro Ala Thr Phe Lys His Lys Leu Lys Glu 
                965                 970                 975     


Ile Ser Ser Glu Gly Val Tyr Val Val Ala Glu Asp Thr Leu Ser Gln 
            980                 985                 990         


Lys Glu Glu Val Val Lys Tyr Leu  Val Leu Glu Gln Glu  Glu Glu Gln 
        995                 1000                 1005             


Asn Leu  Tyr Asp Gly Gln Lys  Gly Phe Gln Trp Thr  Ile Lys Asp 
    1010                 1015                 1020             


Phe Gly  Arg Phe Arg Arg Phe  Met His Asp Arg Arg  Leu Pro Ala 
    1025                 1030                 1035             


Ile Phe  Asn Tyr Leu Glu Thr  Ser Ile Ser Ser Tyr  Asp Leu Leu 
    1040                 1045                 1050             


Ser Tyr  Gln Ile Ser Glu Tyr  Asp Arg Tyr Arg Glu  Ala Ile Phe 
    1055                 1060                 1065             


Arg Glu  Thr Phe Glu Leu Glu  Ala Tyr Leu Ala Asn  Thr Tyr Phe 
    1070                 1075                 1080             


Asp Glu  Val Val Val Leu Lys  Leu Gln Asp Lys Ala  Ile Phe Pro 
    1085                 1090                 1095             


Gln Val  Gln Phe Lys Thr Tyr  Leu Glu Leu Ile Lys  Gln Arg Asn 
    1100                 1105                 1110             


Met Leu  Asp Lys Ala Ala Cys  Glu Phe Ile Asn Ser  Ile Arg Asn 
    1115                 1120                 1125             


Lys Phe  Ser His Ser Glu Phe  Pro Asp Tyr Tyr Pro  Glu Ile Ser 
    1130                 1135                 1140             


Lys Ile  Thr Val Asp Asp Ile  Asp Asp Phe Glu Leu  Asn Lys Ser 
    1145                 1150                 1155             


Lys Lys  Gly Phe Lys Glu Tyr  Ala Gly Leu Ser Ile  Ser Lys Lys 
    1160                 1165                 1170             


Val Phe  Asp Leu Tyr Gln Ser  Ile Met Val Ser Cys  Lys 
    1175                 1180                 1185     


<210>  1700
<211>  1011
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1700

Met Thr Glu Gln Asn Glu Arg Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Phe Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Ala His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Asn Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Tyr Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Gly Thr Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Ser Glu Thr Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Phe Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Asp Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Gly Glu Ile Asp Thr Leu Asp 
    530                 535                 540                 


Arg Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Lys Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Ser Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Leu Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Asp Leu Glu Ala Trp Ala His Ser Ala Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Val Gly Ile Glu Tyr Ala Ser Arg Glu Asn 
    850                 855                 860                 


Lys Lys Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Glu Thr 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Lys Thr Asp Lys Ile Asn Ile Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Thr Lys Glu His Pro Tyr Leu Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asn Ile Arg Thr 
945                 950                 955                 960 


Asp Val Gln Glu Gln Gly Ser Leu Asn Val Leu Asn His Val Lys Pro 
                965                 970                 975     


Met Ala Cys Pro Trp Ser Cys Thr Glu Pro Thr Ala Glu Ala Met Tyr 
            980                 985                 990         


Thr Arg Ser Arg Leu Leu Trp Arg  Arg Ser Ile Ser Lys  Lys Gly Thr 
        995                 1000                 1005             


Pro Ser  Cys 
    1010     


<210>  1701
<211>  1160
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1701

Met Lys Asn Glu Ile Leu Thr Asn Ser Lys Ser Leu Lys Ser Asn Pro 
1               5                   10                  15      


Asp Tyr Phe Ser Ala Tyr Leu Asn Met Ala Arg His Asn Ala Tyr Leu 
            20                  25                  30          


Ile Leu Ser His Ile Ser Asp Lys Leu Lys Pro Lys Lys Thr Asn Thr 
        35                  40                  45              


Pro Glu Asp Ala Leu His Ser Ala Tyr Ala Leu Glu Val Leu Lys Ser 
    50                  55                  60                  


Ser Lys Glu Pro Asp Ile Thr Ala Lys Ser Ile Lys Met Leu Asn Glu 
65                  70                  75                  80  


His Phe Pro Phe Leu Lys Val Met Phe Asp Thr Asn Ser Ile Thr Glu 
                85                  90                  95      


Lys Ser Lys Gly Ser Lys Gly Ile Tyr Ser Glu Lys Leu Pro Glu Gln 
            100                 105                 110         


Tyr Leu Asp Lys Met Met Leu Leu Leu Asp His Leu Asn Asn Tyr Arg 
        115                 120                 125             


Asn Ser Tyr Thr His Cys Val His Ile Pro Ile Ile Asn Asp Lys Asn 
    130                 135                 140                 


Phe Ile Tyr Cys Leu Asn Asn Ile Phe Asp Ala Ser Val Arg Thr Val 
145                 150                 155                 160 


Lys Asp Arg Phe Glu Phe Ser Glu Asn Asp Val Ser His Leu Arg Arg 
                165                 170                 175     


Tyr Glu Gln Val Phe Asp Pro Glu Thr Lys Lys Arg Lys Ala Ser Arg 
            180                 185                 190         


Lys Lys Asp Phe Lys Tyr Asn Phe Ile Asp Asn Asp Asp Ile Ser Glu 
        195                 200                 205             


Lys Gly Ile Ala Phe Phe Ile Ala Leu Phe Leu Glu Lys Lys His Ala 
    210                 215                 220                 


Phe Glu Phe Leu Lys Lys Leu Ser Asp Phe Lys Asp Ser Arg Thr Lys 
225                 230                 235                 240 


Met Met Gln Ala Thr Leu Glu Ser Tyr Cys Val Tyr His Ile Arg Leu 
                245                 250                 255     


Pro Lys Glu Arg Ile Glu Asn Thr Gln Asn Asp Leu Ser Leu Cys Leu 
            260                 265                 270         


Asp Ile Phe Asn Glu Leu Lys Lys Cys Pro Ser Glu Leu Phe Asp Leu 
        275                 280                 285             


Leu Lys Lys Glu Asp Ala Glu Lys Phe Arg Ile Lys Pro Asp Ile Asn 
    290                 295                 300                 


Asn Leu Asn Asp Glu Asp Ser Gly Asn Ile Val Glu Asn Ser Thr Asp 
305                 310                 315                 320 


Asp Tyr Asn Val Glu Pro Ile Leu Lys Arg Tyr Ser Asn Arg Phe Pro 
                325                 330                 335     


Tyr Leu Ala Met Arg Tyr Ile Asp Glu Lys Lys Val Phe Gln Lys Leu 
            340                 345                 350         


Arg Phe His Val Asp Leu Gly Asn Tyr Tyr Phe Lys Phe Tyr Pro Lys 
        355                 360                 365             


Thr Thr Val Asp Gly Glu Lys Arg Asp Arg Ser Leu Lys Val His Leu 
    370                 375                 380                 


Asn Ser Phe Gly Arg Leu Asp Asp Leu Asn His Ala Arg Leu Val Glu 
385                 390                 395                 400 


Trp Asn Asp Leu Ile Arg Phe His Lys Glu Glu Glu Asp Glu Asn Pro 
                405                 410                 415     


Ile Glu Glu Leu Met Pro Tyr Ile Thr Asp Thr Tyr Pro His Tyr His 
            420                 425                 430         


Leu His Asn Asn Gln Ile Gly Leu Lys Asp Thr Gln Asn Asn Pro Asp 
        435                 440                 445             


Lys Leu Leu Pro Lys Ile Glu Arg Glu Lys Thr Lys Thr Glu Gln Pro 
    450                 455                 460                 


Asp Phe Trp Leu Ser Thr Tyr Glu Leu Pro Ala Leu Leu Phe Tyr Ser 
465                 470                 475                 480 


Tyr Leu Leu Lys Lys Lys Arg Asp Ile Ser Ala Glu Asp Leu Ile Leu 
                485                 490                 495     


Asn Cys Arg Lys Lys Tyr His Thr Leu Phe Lys Leu Ile Ser Glu Gly 
            500                 505                 510         


Asn Gly Pro Glu Ile Lys Glu Cys Gln Val Thr Ile Lys Gln Lys Gly 
        515                 520                 525             


Lys Asn Ile Ser Val Phe Leu Leu Thr Ala His Phe Glu Asp Glu Thr 
    530                 535                 540                 


Gly Lys Ser His Glu Ile Glu Leu Asn Asp Leu Pro Gln Val Phe Gln 
545                 550                 555                 560 


Asn Tyr Leu Thr Asp Lys Gln Leu His Asn Arg Glu Glu Leu Ala Glu 
                565                 570                 575     


Asn Lys Ile Asn Arg Leu Ile Ile Glu Thr Glu Arg Arg Arg Glu Lys 
            580                 585                 590         


Ile Asn Lys Asp Leu Glu Arg Ile Asn Gly Leu Lys Gly Asn Lys Arg 
        595                 600                 605             


Gly Lys Lys Asn Phe Val Glu Ile Lys Ser Gly Met Leu Ala Asp Phe 
    610                 615                 620                 


Leu Ala Lys Asp Thr Ile Arg Leu Gln Pro Ser Ile Asp Ala Ile Gly 
625                 630                 635                 640 


Lys Asp Lys Ile Thr Gly Leu Asn Phe Gln Ile Leu Gln Ser His Leu 
                645                 650                 655     


Ala Phe Tyr Gly Arg Asp Phe Leu Met Leu Lys Asp Ile Phe Arg Gln 
            660                 665                 670         


Cys Lys Leu Val Asp Ala Gln Ile Ser His Pro Phe Leu Tyr Lys Leu 
        675                 680                 685             


Asn Pro Glu Asp His Phe Asp Ile Val Ser Phe Tyr Lys Ala Tyr Leu 
    690                 695                 700                 


Gly Glu Arg Lys Lys Tyr Leu Glu Gln Cys Asn Arg Asn Lys Asp Tyr 
705                 710                 715                 720 


Lys Ser Tyr Tyr Phe Leu Lys Phe Asn Ser Gln Lys Phe Thr Thr Glu 
                725                 730                 735     


Thr Ile Glu Tyr Cys Lys Asp Leu Ala Lys Lys Leu Met Asn Thr His 
            740                 745                 750         


Ser Gln Asp Asn His Pro Ile Asn Leu Pro Arg Gly Met Phe Met Asp 
        755                 760                 765             


Ala Ile Ile Asp Trp Phe Lys Lys His Gly Asp Pro Gln Leu Gln Ala 
    770                 775                 780                 


Ile Ala Lys Thr Glu Arg Val Asn Ala Val Tyr Leu Ile Gln Lys Phe 
785                 790                 795                 800 


Phe Glu Phe Lys Lys Asp Ser Asn Gln Pro Phe Tyr Asp Tyr Pro Arg 
                805                 810                 815     


Ser Tyr Asp Phe Ile Asp Lys Leu Glu Asn Phe Asn Asn Met Arg Cys 
            820                 825                 830         


Gly Arg Pro Leu Leu Leu Gln Arg Lys Tyr Tyr Ser Ile Gln Gln Leu 
        835                 840                 845             


Ala Asp Lys Ile Asp Asp Val Lys Thr Arg Ile Thr Lys Leu Pro Glu 
    850                 855                 860                 


Ser Glu Pro Asn Asp Ser His Pro Arg Lys Arg Met Leu Ala Thr Leu 
865                 870                 875                 880 


Ser Asp Tyr Lys Gln Asn Glu Lys Leu Leu Arg Leu Tyr Lys Thr Gln 
                885                 890                 895     


Asp Arg Ile Leu Phe Leu Val Ala Ser Asp Ile Leu Phe Ala Gln Lys 
            900                 905                 910         


Pro Gln Gly Leu Glu Glu Asn Asp Leu Lys Leu Ser Asn Val Lys Pro 
        915                 920                 925             


Lys Pro Glu Asn Asp Ser Asp Glu Asp Leu Leu Ser Ser Gln Leu Pro 
    930                 935                 940                 


Phe Arg Phe Pro Tyr Gln Tyr Trp Asp Val Thr Ser Lys Gly Glu Ile 
945                 950                 955                 960 


Asp His Lys Asn Lys Ile Gly Glu Val Ile Ile Phe Gln Lys Lys Leu 
                965                 970                 975     


Lys Leu Lys Asn Tyr Gly Asp Phe Ile Arg Tyr Thr Lys Asp Arg Arg 
            980                 985                 990         


Leu Asn Asn Leu Phe His Trp Thr  Gly Asp Ile Glu Leu  Glu Met Pro 
        995                 1000                 1005             


Val Leu  Gln Lys Glu Leu Glu  Arg Tyr Glu Glu Ala  Arg Leu Thr 
    1010                 1015                 1020             


Val Phe  Arg Leu Ile His Asp  Phe Glu Lys Ala Met  Tyr Glu Lys 
    1025                 1030                 1035             


His His  Leu Phe Phe Asp Glu  Leu Leu Lys Thr Asn  Lys Leu Lys 
    1040                 1045                 1050             


Lys Glu  Asn Glu Asn Glu Asn  Ser Tyr Ile Asn His  Glu Glu Met 
    1055                 1060                 1065             


Leu Glu  Lys Phe Phe Ser Asp  Tyr Pro Glu Leu Ile  His Tyr Glu 
    1070                 1075                 1080             


Asp Val  Met Leu Thr Ile Arg  Asn Cys Phe Ser His  Asn Gln Tyr 
    1085                 1090                 1095             


Pro Val  Lys Cys Ala Phe Asp  Asn Ile Asp Ser Ile  Gly Leu Phe 
    1100                 1105                 1110             


Glu Gly  Cys Pro Asp Ile Glu  Ser Asp His Asp Asn  Glu Leu Asn 
    1115                 1120                 1125             


Ile Ala  Met Arg Ile Lys Asn  His Ala Ile Ala Thr  Tyr Gly Glu 
    1130                 1135                 1140             


Phe Ile  Lys Ile Leu Thr Asn  Leu Thr Pro Ile His  Asp Ile Asn 
    1145                 1150                 1155             


Val Ser  
    1160 


<210>  1702
<211>  1145
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1702

Met Glu Thr Leu Thr Ile Pro Glu Val Ile Lys Cys Arg Thr Leu Ser 
1               5                   10                  15      


Asp Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Ile Ala Lys Glu Phe Asp Leu Pro Leu 
        35                  40                  45              


Leu Ala Glu Glu Gly His Leu Lys Asn Ser Phe Leu Cys Lys Lys Glu 
    50                  55                  60                  


His Asn Lys Val Asn Trp Asn His Val Tyr Ser Arg Thr Lys Arg Phe 
65                  70                  75                  80  


Leu Ala Val Leu Lys Val Phe Asp Ala Glu Thr Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Lys Thr Ile Asn Trp Glu Gly Lys Asp Phe Ala Ser Met Ser Asp 
            100                 105                 110         


Ile Leu Lys Ile Val Phe Gly Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Thr Ile Arg Lys Thr Ala Val 
    130                 135                 140                 


Ser Ala Glu Met Ala Leu Phe Leu Thr Thr Asn Phe Arg Arg Ala Ile 
145                 150                 155                 160 


Glu Tyr Thr Lys Glu Arg Phe Lys Gly Val Leu Asn Asp Glu Asp Tyr 
                165                 170                 175     


Gln Leu Val Ala Ser Lys Lys Val Leu Glu Ala Asn Ser Thr Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Arg Phe Ile Gly Ile Ile Thr Gly Leu Lys Gly Thr Gln Asn 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro His Asp Arg Phe Gln Ser Asp Asn Pro Arg Gln Ala Phe Ser 
                245                 250                 255     


Leu Asp Leu Ile Asn Glu Leu Asn Arg Cys Pro Lys Val Leu Tyr Asn 
            260                 265                 270         


Ala Ile Thr Glu Glu Gly Lys Gln Lys Leu Arg Ser Ile Pro Gly Glu 
        275                 280                 285             


Leu Glu Asn Lys Asn Leu His Asp Asn Asn Thr Lys Lys Glu Ala Lys 
    290                 295                 300                 


Ile Glu Ala Glu Ala Tyr Glu Leu Tyr Ile Glu Ser Leu Thr Arg Gln 
305                 310                 315                 320 


Ile Arg Tyr Ser Asn Arg Phe Pro Asp Phe Ala Leu Lys Phe Ile Asp 
                325                 330                 335     


Glu Thr Asp Ile Phe Ser Glu Phe Arg Phe Gln Ile Asp Leu Gly Lys 
            340                 345                 350         


Leu Leu Val Asp Glu Tyr Leu Lys Phe Phe Asn Gly Glu His Val Gln 
        355                 360                 365             


Arg Arg Ile Val Glu Asn Ala Lys Ala Phe Gly Lys Leu Ile Asp Phe 
    370                 375                 380                 


Asn Asp Glu Ala Lys Val Met Thr Arg Ile Gly Asn Gly His Phe Ser 
385                 390                 395                 400 


Lys Arg Phe Glu Gln Phe Ala Pro Phe Tyr Asn Thr Glu Asp Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Arg His His Val Thr Ala Lys Leu Gly Pro Asp Ser 
            420                 425                 430         


Lys Gly Glu Pro Glu Lys Lys Leu Leu Gln Pro Leu Pro Glu Ala Phe 
        435                 440                 445             


Leu Ser Leu His Glu Leu Pro Lys Val Ile Leu Leu Asp Tyr Leu Gln 
    450                 455                 460                 


Lys Gly Glu Pro Glu Lys Leu Ile Asn Asp Phe Ile Leu Ile Asn Asn 
465                 470                 475                 480 


Ser Lys Leu Met Asn Met Ser Phe Ile Glu Ala Val Lys Thr Gln Leu 
                485                 490                 495     


Pro Pro Glu Trp Asp Glu Phe Gln Arg Arg Thr Gly Ser Lys Asn Glu 
            500                 505                 510         


Met Pro Tyr Asn Glu Lys Thr Leu Ala Tyr Leu Leu Gln Arg Lys Gln 
        515                 520                 525             


Ile Leu Asn Lys Ile Leu Ala Glu Phe Gln Leu Asn Asp Lys Gln Ile 
    530                 535                 540                 


Pro Gly Arg Ile Leu Asp Tyr Trp Leu Asn Ile Ala Asp Val Glu Glu 
545                 550                 555                 560 


Glu Arg Ala Val Ser Asp Arg Ile Lys Ser Ile Lys Arg Asp Cys Met 
                565                 570                 575     


Ser Arg Leu Arg Ala Leu Gly Lys Phe Lys Ile Asp Arg Asn Arg Asn 
            580                 585                 590         


Lys Ile Pro Lys Ile Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile 
        595                 600                 605             


Val Asp Met Val Val Ser Glu Gly Lys Lys His Lys Ile Thr Ser Phe 
    610                 615                 620                 


Tyr Tyr Glu Lys Met Gln Asp Cys Leu Ser Leu Phe Ala Asp Pro Leu 
625                 630                 635                 640 


Lys Arg Gln Leu Phe Ile His Ile Ile Thr Asn Glu Leu Arg Leu Asn 
                645                 650                 655     


Asp Ser Gly Gly His Pro Phe Leu Phe Lys Leu Asn Met Arg Gln Ile 
            660                 665                 670         


Asn Cys Thr Ser Asp Phe Tyr Glu Ile Tyr Leu Gln Glu Lys Gly His 
        675                 680                 685             


Lys Met Val Pro Glu Lys Asn Leu Lys Thr Gly Lys Val Val Asn Thr 
    690                 695                 700                 


Asp His Ser Trp Met Ala Leu Thr Phe Tyr Lys Leu Glu Phe Asn Asp 
705                 710                 715                 720 


Lys Val Asp Lys Leu Met Thr Val Val Lys Leu Pro Leu Asn Lys Leu 
                725                 730                 735     


Asn Leu Pro Phe Thr Leu Arg Gln Leu Asn Ala Lys Thr Thr Tyr Thr 
            740                 745                 750         


Leu Glu Gln Trp Leu Lys Asn Leu Thr Leu Gly Lys Lys Pro Asp Asp 
        755                 760                 765             


Gly Lys His Pro Val Asn Leu Pro Thr Asn Leu Phe Asp Glu Lys Leu 
    770                 775                 780                 


Ser Asp Leu Leu Arg Gln Asp Leu Asp Asn Asn Lys Ile Ala Tyr Arg 
785                 790                 795                 800 


Pro Tyr Ala Asn Trp Asn Glu Leu Phe Lys Ile Trp Trp Ile Ser Arg 
                805                 810                 815     


Asn Asp Ser Leu Gln Arg Phe Tyr Asn Ala Glu Arg Glu Tyr His Ile 
            820                 825                 830         


Phe Asn Glu Lys Val Asn Phe Tyr Pro Asn Arg Lys Glu Asn Phe Ala 
        835                 840                 845             


Asp Tyr Tyr Gln His Ala Val Lys Val Ala Phe Gln Lys Lys Arg Asn 
    850                 855                 860                 


Glu Arg Ile Ile Glu Gln Arg Ile Asn Lys Tyr Leu Pro Asp Ile Leu 
865                 870                 875                 880 


Phe Glu Gln Val Glu Lys Thr Phe Lys His Thr Ile Ala Glu Thr Glu 
                885                 890                 895     


Lys Glu Ile Arg Ile Leu Gln Glu Glu Asp Arg Ile Met Leu Leu Met 
            900                 905                 910         


Leu Glu Gly Leu Met Glu Asp Gly Asn Lys Gln Gln Leu Lys Leu Ser 
        915                 920                 925             


Glu Ile Lys Thr Leu Gln Asn Ala Thr Ile Asn Ile Arg Gln Leu Val 
    930                 935                 940                 


Pro Gly Lys Leu Ser Phe Asp Asp Ser Gly Glu Ala Ile Lys Asp Ser 
945                 950                 955                 960 


Thr Asn Pro Glu Ile Val Arg Thr Val Ser Val Ser Ile Lys Arg Ile 
                965                 970                 975     


Glu Tyr Asn Leu Leu Pro Lys Tyr Val Ala Asp Gly Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Pro Asp Glu  Glu Ile Gln Met Glu  Arg Leu Lys 
        995                 1000                 1005             


Thr Glu  Phe Asp Thr Tyr Asn  Lys Val Arg Gln Val  Val Leu Asp 
    1010                 1015                 1020             


Leu Ser  Phe Lys Leu Glu Lys  Met Ile Ile Glu Lys  Gly His Lys 
    1025                 1030                 1035             


Asp Arg  Ile Asn Gln Leu Cys  Thr Gly Ala Thr Gly  Glu Leu Leu 
    1040                 1045                 1050             


Thr Gly  Asn Ile Cys His His  Thr Tyr Leu Thr Trp  Leu Lys Asp 
    1055                 1060                 1065             


Lys Glu  Met Ile Asp Asn Glu  Thr Phe Ile Phe Met  Asn Met Val 
    1070                 1075                 1080             


Gln His  Cys Phe Ser His Asn  Gln Tyr Pro Gln Lys  Lys Thr Met 
    1085                 1090                 1095             


Glu Arg  Ile Ile Asn His Trp  Glu Pro Asp Arg Phe  Ala Leu Thr 
    1100                 1105                 1110             


Ile Ala  Ala Thr Tyr Asn Gln  Lys Ile Ala Gly Ile  Leu Glu Asp 
    1115                 1120                 1125             


Ile Gly  Thr Phe Pro Phe Ile  Arg Ser Arg Lys Thr  Met Pro Asp 
    1130                 1135                 1140             


Val Val  
    1145 


<210>  1703
<211>  1160
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1703

Met Lys Asn Glu Ile Leu Thr Asn Ser Lys Ser Leu Lys Ser Asn Pro 
1               5                   10                  15      


Asp Tyr Phe Ser Ala Tyr Leu Asn Met Ala Arg His Asn Ala Tyr Leu 
            20                  25                  30          


Ile Leu Ser His Ile Ser Asp Lys Leu Lys Pro Lys Lys Thr Asn Thr 
        35                  40                  45              


Pro Glu Asp Ala Leu His Ser Ala Tyr Ala Leu Glu Val Leu Lys Ser 
    50                  55                  60                  


Ser Lys Glu Pro Asp Ile Thr Ala Lys Ser Ile Lys Met Leu Asn Glu 
65                  70                  75                  80  


His Phe Pro Phe Leu Lys Val Met Phe Asp Thr Asn Ser Ile Thr Glu 
                85                  90                  95      


Lys Ser Lys Gly Ser Lys Gly Ile Tyr Ser Glu Lys Leu Pro Glu Gln 
            100                 105                 110         


Tyr Leu Asp Lys Met Met Leu Leu Leu Asp His Leu Asn Asn Tyr Arg 
        115                 120                 125             


Asn Ser Tyr Thr His Cys Val His Ile Pro Ile Ile Asn Asp Lys Asn 
    130                 135                 140                 


Phe Ile Tyr Cys Leu Asn Asn Ile Phe Asp Ala Ser Val Arg Thr Val 
145                 150                 155                 160 


Lys Asp Arg Phe Glu Phe Ser Glu Asn Asp Val Ser His Leu Arg Arg 
                165                 170                 175     


Tyr Glu Gln Val Phe Asp Pro Glu Thr Lys Lys Arg Lys Ala Ser Arg 
            180                 185                 190         


Lys Lys Asp Phe Lys Tyr Asn Phe Ile Asp Asn Asp Asp Ile Ser Glu 
        195                 200                 205             


Lys Gly Ile Ala Phe Phe Ile Ala Leu Phe Leu Glu Lys Lys His Ala 
    210                 215                 220                 


Phe Glu Phe Leu Lys Lys Leu Ser Asp Phe Lys Asp Ser Arg Thr Lys 
225                 230                 235                 240 


Met Met Gln Ala Thr Leu Glu Ser Tyr Cys Val Tyr His Ile Arg Leu 
                245                 250                 255     


Pro Lys Glu Arg Ile Glu Asn Thr Gln Asn Asp Leu Ser Leu Cys Leu 
            260                 265                 270         


Asp Ile Phe Asn Glu Leu Lys Lys Cys Pro Ser Glu Leu Phe Asp Leu 
        275                 280                 285             


Leu Lys Lys Glu Asp Ala Glu Lys Phe Arg Ile Lys Pro Asp Ile Asn 
    290                 295                 300                 


Asn Leu Asn Asp Glu Asp Ser Gly Asn Ile Val Glu Asn Ser Thr Asp 
305                 310                 315                 320 


Asp Tyr Asn Val Glu Pro Ile Leu Lys Arg Tyr Ser Asn Arg Phe Pro 
                325                 330                 335     


Tyr Leu Ala Met Arg Tyr Ile Asp Glu Lys Lys Val Phe Gln Lys Leu 
            340                 345                 350         


Arg Phe His Val Asp Leu Gly Asn Tyr Tyr Phe Lys Phe Tyr Pro Lys 
        355                 360                 365             


Thr Thr Val Asp Gly Glu Lys Arg Asp Arg Ser Leu Lys Val His Leu 
    370                 375                 380                 


Asn Ser Phe Gly Arg Leu Asp Asp Leu Asn His Ala Arg Leu Val Glu 
385                 390                 395                 400 


Trp Asn Asp Leu Ile Arg Phe His Lys Glu Glu Glu Asp Glu Asn Pro 
                405                 410                 415     


Ile Glu Glu Leu Met Pro Tyr Ile Thr Asp Thr Tyr Pro His Tyr His 
            420                 425                 430         


Leu His Asn Asn Gln Ile Gly Leu Lys Asp Thr Gln Asn Asn Pro Asp 
        435                 440                 445             


Lys Leu Leu Pro Lys Ile Glu Arg Glu Lys Thr Lys Thr Glu Gln Pro 
    450                 455                 460                 


Asp Phe Trp Leu Ser Thr Tyr Glu Leu Pro Ala Leu Leu Phe Tyr Ser 
465                 470                 475                 480 


Tyr Leu Leu Lys Lys Lys Arg Asp Ile Ser Ala Glu Asp Leu Ile Leu 
                485                 490                 495     


Asn Cys Arg Lys Lys Tyr His Thr Leu Phe Lys Leu Ile Ser Glu Gly 
            500                 505                 510         


Asn Gly Pro Glu Ile Lys Glu Cys Gln Val Thr Ile Lys Gln Lys Gly 
        515                 520                 525             


Lys Asn Ile Ser Val Phe Leu Leu Thr Ala His Phe Glu Asp Glu Thr 
    530                 535                 540                 


Gly Lys Ser His Glu Ile Glu Leu Asn Asp Leu Pro Gln Val Phe Gln 
545                 550                 555                 560 


Asn Tyr Leu Thr Asp Lys Gln Leu His Asn Arg Glu Glu Leu Ala Glu 
                565                 570                 575     


Asn Lys Ile Asn Arg Leu Ile Ile Glu Thr Glu Arg Arg Arg Glu Lys 
            580                 585                 590         


Ile Asn Lys Asp Leu Glu Arg Ile Asn Gly Leu Lys Gly Asn Lys Arg 
        595                 600                 605             


Gly Lys Lys Asn Phe Val Glu Ile Lys Ser Gly Met Leu Ala Asp Phe 
    610                 615                 620                 


Leu Ala Lys Asp Thr Ile Arg Leu Gln Pro Ser Ile Asp Ala Ile Gly 
625                 630                 635                 640 


Lys Asp Lys Ile Thr Gly Leu Asn Phe Gln Ile Leu Gln Ser His Leu 
                645                 650                 655     


Ala Phe Tyr Gly Arg Asp Phe Leu Met Leu Lys Asp Ile Phe Arg Gln 
            660                 665                 670         


Cys Lys Leu Val Asp Ala Gln Ile Ser His Pro Phe Leu Tyr Lys Leu 
        675                 680                 685             


Asn Pro Glu Asp His Phe Asp Ile Val Ser Phe Tyr Lys Ala Tyr Leu 
    690                 695                 700                 


Gly Glu Arg Lys Lys Tyr Leu Glu Gln Cys Asn Arg Asn Lys Asp Tyr 
705                 710                 715                 720 


Lys Ser Tyr Tyr Phe Leu Lys Phe Asn Ser Gln Lys Phe Thr Thr Glu 
                725                 730                 735     


Thr Ile Glu Tyr Cys Lys Asp Leu Ala Lys Lys Leu Met Asn Thr His 
            740                 745                 750         


Ser Gln Asp Asn His Pro Ile Asn Leu Pro Arg Gly Met Phe Met Asp 
        755                 760                 765             


Ala Ile Ile Asp Trp Phe Lys Lys His Gly Asp Pro Gln Leu Gln Ala 
    770                 775                 780                 


Ile Ala Lys Thr Glu Arg Val Asn Ala Val Tyr Leu Ile Gln Lys Phe 
785                 790                 795                 800 


Phe Glu Phe Lys Lys Asp Ser Asn Gln Pro Phe Tyr Asp Tyr Pro Arg 
                805                 810                 815     


Ser Tyr Asp Phe Ile Asp Lys Leu Glu Asn Phe Asn Asn Met Arg Cys 
            820                 825                 830         


Gly Arg Pro Leu Leu Leu Gln Arg Lys Tyr Tyr Ser Ile Gln Gln Leu 
        835                 840                 845             


Ala Asp Lys Ile Asp Asp Val Lys Thr Arg Ile Thr Lys Leu Pro Glu 
    850                 855                 860                 


Ser Glu Pro Asn Asp Ser His Pro Arg Lys Arg Met Leu Ala Thr Leu 
865                 870                 875                 880 


Ser Asp Tyr Lys Gln Asn Glu Lys Leu Leu Arg Leu Tyr Lys Thr Gln 
                885                 890                 895     


Asp Arg Ile Leu Phe Leu Val Ala Ser Asp Ile Leu Phe Ala Gln Lys 
            900                 905                 910         


Pro Gln Gly Leu Glu Glu Asn Asp Leu Lys Leu Ser Asn Val Lys Pro 
        915                 920                 925             


Lys Pro Glu Asn Asp Ser Asp Glu Asp Leu Leu Ser Ser Gln Leu Pro 
    930                 935                 940                 


Phe Arg Phe Pro Tyr Gln Tyr Trp Asp Val Thr Ser Lys Gly Glu Ile 
945                 950                 955                 960 


Asp His Lys Asn Lys Ile Gly Glu Val Ile Ile Phe Gln Lys Lys Leu 
                965                 970                 975     


Lys Leu Lys Asn Tyr Gly Asp Phe Ile Arg Tyr Thr Lys Asp Arg Arg 
            980                 985                 990         


Leu Asn Asn Leu Phe His Trp Thr  Gly Asp Ile Glu Leu  Glu Met Pro 
        995                 1000                 1005             


Val Leu  Gln Lys Glu Leu Glu  Arg Tyr Glu Glu Ala  Arg Leu Thr 
    1010                 1015                 1020             


Val Phe  Arg Leu Ile His Asp  Phe Glu Lys Ala Met  Tyr Glu Lys 
    1025                 1030                 1035             


His His  Leu Phe Phe Asp Glu  Leu Leu Lys Thr Asn  Lys Leu Lys 
    1040                 1045                 1050             


Lys Glu  Asn Glu Asn Glu Asn  Ser Tyr Ile Asn His  Glu Glu Met 
    1055                 1060                 1065             


Leu Glu  Lys Phe Phe Ser Asp  Tyr Pro Glu Leu Ile  His Tyr Glu 
    1070                 1075                 1080             


Asp Val  Met Leu Thr Ile Arg  Asn Cys Phe Ser His  Asn Gln Tyr 
    1085                 1090                 1095             


Pro Val  Lys Cys Ala Phe Asp  Asn Ile Asp Ser Ile  Gly Leu Phe 
    1100                 1105                 1110             


Glu Gly  Cys Pro Asp Ile Glu  Ser Asp His Asp Asn  Glu Leu Asn 
    1115                 1120                 1125             


Ile Ala  Met Arg Ile Lys Asn  His Ala Ile Ala Thr  Tyr Gly Glu 
    1130                 1135                 1140             


Phe Ile  Lys Ile Leu Thr Asn  Leu Thr Pro Ile His  Asp Ile Asn 
    1145                 1150                 1155             


Val Ser  
    1160 


<210>  1704
<211>  1145
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1704

Met Glu Thr Leu Thr Ile Pro Glu Val Ile Lys Cys Arg Thr Leu Ser 
1               5                   10                  15      


Asp Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Ile Ala Lys Glu Phe Asp Leu Pro Leu 
        35                  40                  45              


Leu Ala Glu Glu Gly His Leu Lys Asn Ser Phe Leu Cys Lys Lys Glu 
    50                  55                  60                  


His Asn Lys Val Asn Trp Asn His Val Tyr Ser Arg Thr Lys Arg Phe 
65                  70                  75                  80  


Leu Ala Val Leu Lys Val Phe Asp Ala Glu Thr Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Lys Thr Ile Asn Trp Glu Gly Lys Asp Phe Ala Ser Met Ser Asp 
            100                 105                 110         


Ile Leu Lys Ile Val Phe Gly Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Thr Ile Arg Lys Thr Ala Val 
    130                 135                 140                 


Ser Ala Glu Met Ala Leu Phe Leu Thr Thr Asn Phe Arg Arg Ala Ile 
145                 150                 155                 160 


Glu Tyr Thr Lys Glu Arg Phe Lys Gly Val Leu Asn Asp Glu Asp Tyr 
                165                 170                 175     


Gln Leu Val Ala Ser Lys Lys Val Leu Glu Ala Asn Ser Thr Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Arg Phe Ile Gly Ile Ile Thr Gly Leu Lys Gly Thr Gln Asn 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro His Asp Arg Phe Gln Ser Asp Asn Pro Arg Gln Ala Phe Ser 
                245                 250                 255     


Leu Asp Leu Ile Asn Glu Leu Asn Arg Cys Pro Lys Val Leu Tyr Asn 
            260                 265                 270         


Ala Ile Thr Glu Glu Gly Lys Gln Lys Leu Arg Ser Ile Pro Gly Glu 
        275                 280                 285             


Leu Glu Asn Lys Asn Leu His Asp Asn Asn Thr Lys Lys Glu Ala Lys 
    290                 295                 300                 


Ile Glu Ala Glu Ala Tyr Glu Leu Tyr Ile Glu Ser Leu Thr Arg Gln 
305                 310                 315                 320 


Ile Arg Tyr Ser Asn Arg Phe Pro Asp Phe Ala Leu Lys Phe Ile Asp 
                325                 330                 335     


Glu Thr Asp Ile Phe Ser Glu Phe Arg Phe Gln Ile Asp Leu Gly Lys 
            340                 345                 350         


Leu Leu Val Asp Glu Tyr Leu Lys Phe Phe Asn Gly Glu His Val Gln 
        355                 360                 365             


Arg Arg Ile Val Glu Asn Ala Lys Ala Phe Gly Lys Leu Ile Asp Phe 
    370                 375                 380                 


Asn Asp Glu Ala Lys Val Met Thr Arg Ile Gly Asn Gly His Phe Ser 
385                 390                 395                 400 


Lys Arg Phe Glu Gln Phe Ala Pro Phe Tyr Asn Thr Glu Asp Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Arg His His Val Thr Ala Lys Leu Gly Pro Asp Ser 
            420                 425                 430         


Lys Gly Glu Pro Glu Lys Lys Leu Leu Gln Pro Leu Pro Glu Ala Phe 
        435                 440                 445             


Leu Ser Leu His Glu Leu Pro Lys Val Ile Leu Leu Asp Tyr Leu Gln 
    450                 455                 460                 


Lys Gly Glu Pro Glu Lys Leu Ile Asn Asp Phe Ile Leu Ile Asn Asn 
465                 470                 475                 480 


Ser Lys Leu Met Asn Met Ser Phe Ile Glu Ala Val Lys Thr Gln Leu 
                485                 490                 495     


Pro Pro Glu Trp Asp Glu Phe Gln Arg Arg Thr Gly Ser Lys Asn Glu 
            500                 505                 510         


Met Pro Tyr Asn Glu Lys Thr Leu Ala Tyr Leu Leu Gln Arg Lys Gln 
        515                 520                 525             


Ile Leu Asn Lys Ile Leu Ala Glu Phe Gln Leu Asn Asp Lys Gln Ile 
    530                 535                 540                 


Pro Gly Arg Ile Leu Asp Tyr Trp Leu Asn Ile Ala Asp Val Glu Glu 
545                 550                 555                 560 


Glu Arg Ala Val Ser Asp Arg Ile Lys Ser Ile Lys Arg Asp Cys Met 
                565                 570                 575     


Ser Arg Leu Arg Ala Leu Gly Lys Phe Lys Ile Asp Arg Asn Arg Asn 
            580                 585                 590         


Lys Ile Pro Lys Ile Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile 
        595                 600                 605             


Val Asp Met Val Val Ser Glu Gly Lys Lys His Lys Ile Thr Ser Phe 
    610                 615                 620                 


Tyr Tyr Glu Lys Met Gln Asp Cys Leu Ser Leu Phe Ala Asp Pro Leu 
625                 630                 635                 640 


Lys Arg Gln Leu Phe Ile His Ile Ile Thr Asn Glu Leu Arg Leu Asn 
                645                 650                 655     


Asp Ser Gly Gly His Pro Phe Leu Phe Lys Leu Asn Met Arg Gln Ile 
            660                 665                 670         


Asn Cys Thr Ser Asp Phe Tyr Glu Ile Tyr Leu Gln Glu Lys Gly His 
        675                 680                 685             


Lys Met Val Pro Glu Lys Asn Leu Lys Thr Gly Lys Val Val Asn Thr 
    690                 695                 700                 


Asp His Ser Trp Met Ala Leu Thr Phe Tyr Lys Leu Glu Phe Asn Asp 
705                 710                 715                 720 


Lys Val Asp Lys Leu Met Thr Val Val Lys Leu Pro Leu Asn Lys Leu 
                725                 730                 735     


Asn Leu Pro Phe Thr Leu Arg Gln Leu Asn Ala Lys Thr Thr Tyr Thr 
            740                 745                 750         


Leu Glu Gln Trp Leu Lys Asn Leu Thr Leu Gly Lys Lys Pro Asp Asp 
        755                 760                 765             


Gly Lys His Pro Val Asn Leu Pro Thr Asn Leu Phe Asp Glu Lys Leu 
    770                 775                 780                 


Ser Asp Leu Leu Arg Gln Asp Leu Asp Asn Asn Lys Ile Ala Tyr Arg 
785                 790                 795                 800 


Pro Tyr Ala Asn Trp Asn Glu Leu Phe Lys Ile Trp Trp Ile Ser Arg 
                805                 810                 815     


Asn Asp Ser Leu Gln Arg Phe Tyr Asn Ala Glu Arg Glu Tyr His Ile 
            820                 825                 830         


Phe Asn Glu Lys Val Asn Phe Tyr Pro Asn Arg Lys Glu Asn Phe Ala 
        835                 840                 845             


Asp Tyr Tyr Gln His Ala Val Lys Val Ala Phe Gln Lys Lys Arg Asn 
    850                 855                 860                 


Glu Arg Ile Ile Glu Gln Arg Ile Asn Lys Tyr Leu Pro Asp Ile Leu 
865                 870                 875                 880 


Phe Glu Gln Val Glu Lys Thr Phe Lys His Thr Ile Ala Glu Thr Glu 
                885                 890                 895     


Lys Glu Ile Arg Ile Leu Gln Glu Glu Asp Arg Ile Met Leu Leu Met 
            900                 905                 910         


Leu Glu Gly Leu Met Glu Asp Gly Asn Lys Gln Gln Leu Lys Leu Ser 
        915                 920                 925             


Glu Ile Lys Thr Leu Gln Asn Ala Thr Ile Asn Ile Arg Gln Leu Val 
    930                 935                 940                 


Pro Gly Lys Leu Ser Phe Asp Asp Ser Gly Glu Ala Ile Lys Asp Ser 
945                 950                 955                 960 


Thr Asn Pro Glu Ile Val Arg Thr Val Ser Val Ser Ile Lys Arg Ile 
                965                 970                 975     


Glu Tyr Asn Leu Leu Pro Lys Tyr Val Ala Asp Gly Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Pro Asp Glu  Glu Ile Gln Met Glu  Arg Leu Lys 
        995                 1000                 1005             


Thr Glu  Phe Asp Thr Tyr Asn  Lys Val Arg Gln Val  Val Leu Asp 
    1010                 1015                 1020             


Leu Ser  Phe Lys Leu Glu Lys  Met Ile Ile Glu Lys  Gly His Lys 
    1025                 1030                 1035             


Asp Arg  Ile Asn Gln Leu Cys  Thr Gly Ala Thr Gly  Glu Leu Leu 
    1040                 1045                 1050             


Thr Gly  Asn Ile Cys His His  Thr Tyr Leu Thr Trp  Leu Lys Asp 
    1055                 1060                 1065             


Lys Glu  Met Ile Asp Asn Glu  Thr Phe Ile Phe Met  Asn Met Val 
    1070                 1075                 1080             


Gln His  Cys Phe Ser His Asn  Gln Tyr Pro Gln Lys  Lys Thr Met 
    1085                 1090                 1095             


Glu Arg  Ile Ile Asn His Trp  Glu Pro Asp Arg Phe  Ala Leu Thr 
    1100                 1105                 1110             


Ile Ala  Ala Thr Tyr Asn Gln  Lys Ile Ala Gly Ile  Leu Glu Asp 
    1115                 1120                 1125             


Ile Gly  Thr Phe Pro Phe Ile  Arg Ser Arg Lys Thr  Met Pro Asp 
    1130                 1135                 1140             


Val Val  
    1145 


<210>  1705
<211>  1126
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1705

Met Glu Thr Leu Leu Thr Pro Thr Glu Asn Lys Tyr Arg Thr Ile Asn 
1               5                   10                  15      


Asp Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Ser Met Ala Arg Leu Asn 
            20                  25                  30          


Val Phe Asn Ile Ser Asn His Ile Ala Lys Glu Phe Gly Gln Ser Leu 
        35                  40                  45              


Leu Glu Glu Glu Gly His Ile Lys Asn Ser Phe Leu Cys Asp Lys Asn 
    50                  55                  60                  


Asn Lys Lys Val Asn Trp Asn His Val His Ala Lys Ala Arg Arg Phe 
65                  70                  75                  80  


Leu Ser Ile Leu Lys Val Phe Asp Ala Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Leu Lys Ile Ile Glu Trp Glu Gly Lys Asp Phe Ser Leu Met Gly Asp 
            100                 105                 110         


Thr Leu Lys Ile Val Phe Arg Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Phe Tyr Ser Thr Glu Lys Gly Thr Ser Arg Lys Ile Lys Val 
    130                 135                 140                 


Ser Glu Glu Leu Ala Glu Phe Leu Lys Thr Asn Phe Arg Arg Ala Ile 
145                 150                 155                 160 


Glu Tyr Thr Lys Glu Arg Phe Lys Gly Gly Leu Ile Glu Glu Asp Phe 
                165                 170                 175     


Asn Leu Val Ala Ser Arg Lys Val Val Arg Asp Asp Leu Ala Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ala Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Thr Gly Leu Lys Gly Thr Gln Asn 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro His Asp Arg Phe Gln Ser Asp Asn Thr Arg Gln Ala Phe Ser 
                245                 250                 255     


Leu Asp Leu Ile Asn Glu Leu Asn Arg Cys Pro Lys Val Leu Tyr Asn 
            260                 265                 270         


Val Ile Thr Glu Glu Gly Lys Gln Leu Phe Arg Pro Gln Leu Glu Asp 
        275                 280                 285             


Leu Glu Ile Lys Asn Leu Ile Lys Asn Ser Thr Asn Asn Glu Glu Glu 
    290                 295                 300                 


Ile Asp Asn Tyr Asp Glu Tyr Ile Glu Ala Leu Thr Lys Arg Ile Arg 
305                 310                 315                 320 


His Thr Asn Arg Phe Ser Asp Phe Ala Leu Gln Phe Ile Asp Glu Thr 
                325                 330                 335     


Asp Val Phe Lys Lys Phe Arg Phe Gln Ile Asp Leu Gly Lys Leu Leu 
            340                 345                 350         


Val Asp Glu Tyr Asp Lys Ser Phe Asn Gly Glu Glu Val Glu Arg Lys 
        355                 360                 365             


Ile Ile Val Asn Ala Lys Ala Phe Arg Lys Leu Asn Ser Tyr Gly Thr 
    370                 375                 380                 


Glu Asp Glu Thr Leu Lys Leu Ile Glu Asn Gly Gln Gly Ser Lys Arg 
385                 390                 395                 400 


Phe Glu Gln Phe Ala Pro His Tyr Asn Thr Glu Asn Asn Lys Ile Gly 
                405                 410                 415     


Leu Ser Gly Lys Glu Leu Ile Ala Lys Leu Arg Pro Asn Ser Lys Gly 
            420                 425                 430         


Glu Ala Gly Lys Lys Leu His Gln Pro Leu Pro Glu Ala Phe Leu Ser 
        435                 440                 445             


Leu Lys Glu Leu Pro Lys Ile Ile Leu Leu Asn Tyr Leu Leu Pro Asp 
    450                 455                 460                 


Glu Pro Glu Lys Leu Ile Asn Asp Phe Ile Leu Val Asn Asn Ser Lys 
465                 470                 475                 480 


Leu Met Asn Met Ser Phe Ile Lys Glu Val Lys Ser Leu Leu Pro Lys 
                485                 490                 495     


Glu Trp Asn Glu Phe Lys Lys Arg Ser Asp Thr Lys Lys Gln Arg Ala 
            500                 505                 510         


Tyr Asn Glu Lys Ala Leu Ala Tyr Leu Leu His Arg Lys Gln Ile Leu 
        515                 520                 525             


Asn Gln Val Leu Ala Ala Tyr Gln Leu Asn Asp Lys Gln Ile Pro Arg 
    530                 535                 540                 


Arg Ile Leu Asp Tyr Trp Leu Asn Ile Val Asp Val Val Glu Gly Arg 
545                 550                 555                 560 


Ser Val Ser Asp Arg Ile Lys Met Met Lys Arg Asp Cys Met Ser Arg 
                565                 570                 575     


Leu Lys Ala Met Ala Lys Phe Lys Glu Asp Arg Asn Arg Asn Lys Ile 
            580                 585                 590         


Pro Lys Ile Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile Val Asp 
        595                 600                 605             


Met Val Val Gly Glu Glu Lys Lys Gln Lys Ile Thr Ser Phe Tyr Tyr 
    610                 615                 620                 


Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Pro Glu Lys Lys 
625                 630                 635                 640 


Gln Leu Phe Ile His Thr Val Ile Asn Glu Leu Lys Leu Asn Glu Gln 
                645                 650                 655     


Gly Gly His Pro Phe Leu His Lys Leu Asn Leu Gln Gln Ile Lys Asn 
            660                 665                 670         


Thr Ser Gly Phe Tyr Glu Ile Tyr Leu Gln Glu Lys Gly Gln Lys Met 
        675                 680                 685             


Val Ser Glu Lys Asn Phe Arg Thr Gly Arg Thr Ile Glu Thr Asp Lys 
    690                 695                 700                 


Ser Trp Met Ala Leu Thr Phe Tyr Lys Lys Glu Trp Asp Glu Lys Val 
705                 710                 715                 720 


Gly Lys Gln Leu Thr Val Val Arg Leu Pro Glu Asn Lys Ser Asn Ile 
                725                 730                 735     


Pro Phe Ser Leu Arg Leu Leu Glu Glu Lys Thr Val Tyr Thr Leu Glu 
            740                 745                 750         


Gln Trp Leu His Asn Val Thr Lys Gly Lys Lys Gln Asn Asp Thr Arg 
        755                 760                 765             


Gln Pro Val Asn Leu Pro Thr Asn Leu Phe Asp Glu Arg Leu Thr Val 
    770                 775                 780                 


Leu Leu Arg Gly Glu Leu Asp Lys Lys Gln Ile Ser Tyr Ala Pro Asn 
785                 790                 795                 800 


Ala Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Lys Ser Arg Asn Asp 
                805                 810                 815     


Ser Val Gln Ser Phe Tyr Lys Ala Glu Arg Glu Tyr Glu Ile Phe Gly 
            820                 825                 830         


Glu Lys Val Asn Phe Met Pro Asp Ser Lys Glu Arg Phe Ala Asp Tyr 
        835                 840                 845             


Tyr Gln His Ala Leu Thr Ala Ala Trp Gln Lys Lys Arg Lys Glu Arg 
    850                 855                 860                 


Ile Gln Gln Gln Lys Gln Asp Arg Arg Leu Pro Asp Ile Ser Phe Asp 
865                 870                 875                 880 


Gln Val Glu Lys Thr Phe Lys Gln Thr Ile Ala Glu Thr Glu Lys Glu 
                885                 890                 895     


Ile Arg Ile Val Gln Glu Glu Asp Arg Met Met Leu Leu Met Leu Glu 
            900                 905                 910         


Thr Leu Met Glu Asn Gly Lys Asp Leu Lys Leu Lys Leu Ser Gly Ile 
        915                 920                 925             


Asp Thr Leu Leu Asn Ala Thr Thr Glu Val Lys Gln Leu Val Ser Gly 
    930                 935                 940                 


Lys Leu Ser Phe Asn Gly Ser Gly Glu Leu Ile Lys Gly Lys Thr Asn 
945                 950                 955                 960 


Pro Glu Ile Ser Lys Thr Ile Thr Val Ala Arg Lys Arg Lys Asp Tyr 
                965                 970                 975     


Ser Met Leu Arg Lys Phe Val Phe Asp Arg Arg Leu Pro Glu Leu Phe 
            980                 985                 990         


Glu Tyr Phe Ala Glu Glu Glu Ile  Pro Ile Glu Val Leu  Lys Asp Glu 
        995                 1000                 1005             


Leu Asp  Ala Tyr Asn Lys Ala  Lys His Glu Val Phe  Asp Thr Val 
    1010                 1015                 1020             


Phe Glu  Leu Glu Glu Lys Ile  Ile Thr Leu Asp Ala  Asp Gly Ile 
    1025                 1030                 1035             


Arg Gln  Leu Phe Ile Asp Asp  Ala Gly Gln Pro Val  Thr Gly Asn 
    1040                 1045                 1050             


Ile Gln  His Lys Pro Tyr Val  Ile Trp Leu Lys Asn  Asn Gly Thr 
    1055                 1060                 1065             


Ile Asp  Asp Asn Thr Leu Thr  Phe Leu Asn Met Val  Arg Asn Cys 
    1070                 1075                 1080             


Phe Ser  His Asn Gln Tyr Pro  Gln Lys Lys Thr Met  Glu Leu Leu 
    1085                 1090                 1095             


Ile Gly  Gln Trp Glu Pro Asn  Arg Phe Ala Leu Thr  Ile Ala Gln 
    1100                 1105                 1110             


Thr Tyr  Lys Arg Lys Ile Asn  Ser Ile Met Lys His  Leu 
    1115                 1120                 1125     


<210>  1706
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1706

Met Glu Thr Lys Gln Gln Val Gly Lys Gly Ile Ser Tyr Asp His Arg 
1               5                   10                  15      


Arg Pro Asp Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asp Gly Val Ile Gln Glu Phe Ala Met Arg Leu Asn Arg 
        35                  40                  45              


Glu Tyr Asp Pro Glu Asn Lys Asn Gln Ser Leu Phe Ser Tyr Phe Asn 
    50                  55                  60                  


Ile Asn Ala Ser Phe Thr Asp Trp Glu Arg Gly Val Asn Ile Leu Lys 
65                  70                  75                  80  


Glu Tyr Trp Pro Met Met Glu Phe Ile Asp Arg Pro Ala Thr Asp Lys 
                85                  90                  95      


Gln Phe Glu Ala Glu Lys Pro Glu Asn Arg Glu Ala Ala Lys Arg Lys 
            100                 105                 110         


Tyr Phe Leu Ala Thr Leu Gly Ala Leu Leu Thr Ser Ile Lys Asp Leu 
        115                 120                 125             


Arg His Tyr Tyr Thr His Tyr Tyr His Pro Pro Val His Leu Asn Asp 
    130                 135                 140                 


Asp Leu Phe Leu Phe Leu Asp His Ala Leu Leu Tyr Thr Ala Phe Asp 
145                 150                 155                 160 


Val Lys Lys Thr Lys Met Lys Asp Asp Lys Thr Arg Gln Leu Leu Asn 
                165                 170                 175     


Gln Asn Leu Ser Leu Glu Leu Glu Lys Leu Lys Lys Leu Lys Val Glu 
            180                 185                 190         


Glu Leu Lys Lys Lys Lys Glu Lys Gly Ile Lys Val Asn Leu Gln Asp 
        195                 200                 205             


Glu Lys Gly Ile Leu Asn Ala Ile Tyr Asn Asp Ala Phe Ala His Ile 
    210                 215                 220                 


Ile Thr Lys Glu Lys Asp Ser Asp Lys Asp Lys Leu Glu Thr Arg Tyr 
225                 230                 235                 240 


Lys Ser Ile Leu Pro Gln Asp Glu Ala Ala Glu Thr Gly Ile Asn Ile 
                245                 250                 255     


Ser Ile Ser Gly Leu Ile Phe Leu Leu Ser Leu Phe Leu Ser Arg Lys 
            260                 265                 270         


Glu Ile Glu Gln Leu Lys Ser Asn Ile Glu Gly Tyr Lys Gly Lys Val 
        275                 280                 285             


Leu Asn Ile Glu Thr Glu Val Asp Arg Lys His Asn Ser Leu Lys Tyr 
    290                 295                 300                 


Met Ala Thr His Trp Val Phe Ser Ile Leu Ala Phe Lys Gly Leu Lys 
305                 310                 315                 320 


Gln Arg Leu Thr Asn Ser Phe Glu Lys Glu Ser Leu Leu Ile Gln Met 
                325                 330                 335     


Met Asp Glu Leu Asn Lys Val Pro Asp Glu Leu Tyr Gln Thr Leu Ser 
            340                 345                 350         


Glu Thr Ala Lys Lys Glu Phe Leu Glu Asp Ile Asn Glu Tyr Val Ser 
        355                 360                 365             


Glu Gly Asp Asp Asn Glu Lys Ala Thr Tyr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Ser Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gln Phe Pro Thr Leu Lys Phe Gln Ile Phe Val Gly 
                405                 410                 415     


Gln Tyr Leu His Asp Asn Arg Pro Lys Thr Leu Ala Ser Asn Gly Met 
            420                 425                 430         


Thr Ala Gln Arg Met Ile Lys Glu Lys Ile Asn Leu Phe Gly Asn Leu 
        435                 440                 445             


Ser Glu Val Thr Lys His Lys Ser Asp Phe Phe Glu Lys Glu Ser Ala 
    450                 455                 460                 


Ala Gln Gly Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Trp Ala Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Val Tyr Ile Asp Met Ile Gly Lys Glu Gly Lys Ala 
                485                 490                 495     


Lys Glu Ile Gln Val Gln Ile Asn Lys Tyr Arg Lys Gln Leu Asn Pro 
            500                 505                 510         


Ala Pro Gln Arg Asp Lys Arg Ile Ser Lys Lys Glu Ile Ile Glu Gln 
        515                 520                 525             


Leu Tyr Lys Glu Lys Val Val Tyr Gly Asp Pro Thr Leu Met Leu Ser 
    530                 535                 540                 


Ala Asn Glu Leu Met Ala Leu Leu Tyr Glu Leu Ile Val Asn Gly Lys 
545                 550                 555                 560 


Ser Gly Ala Glu Leu Glu Asn Lys Ile Val Glu Gln Ile Ile Ala Arg 
                565                 570                 575     


Tyr Glu Gln Ile Glu Ala Tyr Asp Pro Thr Thr Gln Gln Leu Pro Thr 
            580                 585                 590         


Asn Gln Met Pro His Lys Leu Gln Lys Ser Arg Lys Asp Ser Lys Val 
        595                 600                 605             


Thr Asp Thr Asp Lys Leu Leu Lys Thr Ile Asp Lys Glu Ile Asp Glu 
    610                 615                 620                 


Gly Asn Lys Lys Leu Glu Leu Ile Ala Cys His Arg Lys Glu Trp Glu 
625                 630                 635                 640 


Glu Ala Glu Gln Arg Lys Lys Ser Gly Lys Arg Asn Asn Pro Gly Thr 
                645                 650                 655     


Lys Ser Arg Lys His Leu Phe Tyr Ala Ser Glu Met Gly Glu Glu Ala 
            660                 665                 670         


Thr Trp Ile Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Pro Ala Arg 
        675                 680                 685             


Ala Glu Trp Lys Gly Thr His His Ser Glu Leu Gln Arg Leu Leu Ala 
    690                 695                 700                 


Phe Tyr Ser Thr Gln Arg Leu Glu Ala Trp Gln Leu Val Glu Ser Val 
705                 710                 715                 720 


Trp Thr Ala Asn Thr His Ser Phe Trp Glu Glu Asn Phe Lys Glu Ala 
                725                 730                 735     


Phe Tyr Lys Pro Glu Phe Glu Asn Phe Tyr Gly Ala Tyr Ile Glu Ile 
            740                 745                 750         


Arg Thr Lys Ile Leu Thr Thr Cys Arg Ser Ile Leu Glu Asn Asn Pro 
        755                 760                 765             


Glu Ala Thr Met Asn Asn Asp Thr Glu Lys Glu Trp Asp Lys Val Phe 
    770                 775                 780                 


Thr Leu Phe Asp Lys Arg Leu Tyr Arg Thr Ser Thr Thr Asp Glu Gln 
785                 790                 795                 800 


Lys Lys Gln Leu Leu Thr Lys Pro Phe Ala Phe Pro Arg Gly Leu Phe 
                805                 810                 815     


Asp Asp Lys Pro Thr Phe Leu Pro Gly Ser Lys Pro Asn Glu Asn Pro 
            820                 825                 830         


Glu Arg Phe Ala Ala Trp Tyr Ser Tyr Gly Tyr Thr Tyr Ser Gly Lys 
        835                 840                 845             


Phe Gln Ser Phe Tyr Asp Met Pro Arg Asn Tyr Ser Asp Trp Tyr Lys 
    850                 855                 860                 


Lys Leu Lys Glu Asp Gly Lys Leu Pro Arg Leu Asp Lys Lys Thr Glu 
865                 870                 875                 880 


Gln Glu Lys Ile Leu Arg Phe Arg Met Asp Cys Asp Leu Asn Ile Lys 
                885                 890                 895     


His Ile Arg Phe Gln Asp Ile Tyr Val Lys Leu Met Val Asp Ser Leu 
            900                 905                 910         


Tyr Lys Ala Val Phe Gly Gln Gln Pro Glu Phe Asp Leu Ser His Leu 
        915                 920                 925             


Tyr Asp Thr Arg Ser Glu Arg Tyr Glu Asn Asn Thr Ile Ala Gln Arg 
    930                 935                 940                 


Gln Lys Ser Arg Gln Glu Gly Asp Asn Ser Asp Asn Ala Ile Asn Glu 
945                 950                 955                 960 


Asn Tyr Val Trp Asn Lys Thr Phe Ala Ile Ser Leu Tyr Asn Gly Arg 
                965                 970                 975     


Ile Thr Glu Ser Gln Val Lys Leu Lys Asp Val Gly Lys Phe Arg Arg 
            980                 985                 990         


Phe Ala Thr Asp Pro Arg Val Gln  Thr Leu Ile Ser Tyr  Asp Asp Thr 
        995                 1000                 1005             


Arg Thr  Trp Thr Lys Leu Glu  Ile Glu Asn Glu Leu  Asp Asn Lys 
    1010                 1015                 1020             


Ala Asp  Ala Tyr Glu Pro Ile  Arg Arg Thr Gln Ser  Leu Lys Ala 
    1025                 1030                 1035             


Ile Gln  Gln Leu Glu Lys Asn  Ile Leu Lys Lys Asn  Gly Phe Asn 
    1040                 1045                 1050             


Gly Lys  Gln His Pro Glu Glu  Leu Lys His Asn Gly  Asn Pro Asn 
    1055                 1060                 1065             


Phe Arg  Lys Tyr Ile Ala Asn  Gly Leu Leu Lys His  Arg Thr Asp 
    1070                 1075                 1080             


Ile Arg  Gln Glu Glu Leu Ala  Leu Ile Ser Asp Thr  Glu Phe Gln 
    1085                 1090                 1095             


Glu Ile  Gly Leu Glu Arg Ile  Arg Gln Thr Asn Pro  Leu Ile Gln 
    1100                 1105                 1110             


Lys Ala  Tyr Leu Leu Ile Leu  Leu Arg Asn Lys Phe  Gly His Asn 
    1115                 1120                 1125             


Gln Leu  Pro Asp Gln Glu His  Phe Arg Leu Met Arg  Ser Ile Tyr 
    1130                 1135                 1140             


Pro Tyr  Asn Gln Gln Glu Ser  Tyr Ser Ala Tyr Phe  Asn His Val 
    1145                 1150                 1155             


Ile Thr  Gln Ile Ile Glu Glu  Leu Asn Thr 
    1160                 1165             


<210>  1707
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1707

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1708
<211>  1156
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1708

Met Glu Asn His Thr Lys Gln Thr Thr Tyr Lys Tyr Asp Glu Ile Ala 
1               5                   10                  15      


Asp Lys His Tyr Phe Ala Gly Phe Phe Asn Leu Ala Trp Asn Asn Ile 
            20                  25                  30          


Glu Ile Val Phe Lys Val Phe Leu Lys Lys Phe Lys Leu Ile Glu Asp 
        35                  40                  45              


Lys Asp Lys Lys Ile Glu Val Asn Pro Leu Ser Phe Val Asp Asn Tyr 
    50                  55                  60                  


Phe Lys Asn Glu Leu Ala Leu Ser Asp Tyr Arg Asp Arg Ile Asp Phe 
65                  70                  75                  80  


Leu Lys Gln Tyr Phe Pro Val Val Gln Tyr Leu Glu Leu Leu Val Ser 
                85                  90                  95      


Lys Asn Asn Asp Leu Glu Lys Cys Ile Gly Glu Glu Lys Glu Asn Lys 
            100                 105                 110         


Arg Arg Glu Cys Phe Arg Ala Lys Phe Lys Ser Leu Ile Arg Thr Ile 
        115                 120                 125             


Asn Glu Leu Arg Asn Tyr Tyr Thr His His Tyr His Lys Pro Ile Ile 
    130                 135                 140                 


Val Asp Glu Ala Thr Phe Glu Leu Leu Asp Glu Leu Phe Leu Thr Val 
145                 150                 155                 160 


Val Lys Glu Val Lys Arg Tyr Lys Met Lys Gly Glu Pro Ile Arg His 
                165                 170                 175     


Leu Phe Lys Lys Glu Leu Asn Asn Glu Leu Thr Ala Leu Ile Lys Leu 
            180                 185                 190         


Lys Lys Ser Glu Leu Glu Thr Arg Arg Lys Glu Gly Lys Arg Val Asn 
        195                 200                 205             


Ile Asp Pro Val Ser Ile Glu Asn Ala Val Leu Asn Asp Ala Phe Ser 
    210                 215                 220                 


His Leu Leu Phe Gly Glu Lys Gly Glu Lys Phe Tyr Gln Ser Lys Ser 
225                 230                 235                 240 


Thr Ser Ser Asn Gln Gln Ser Thr Ile Asn Ile Ser Glu Ser Gly Leu 
                245                 250                 255     


Leu Phe Leu Leu Gly Met Phe Leu His Arg Lys Glu Ser Glu Arg Leu 
            260                 265                 270         


Arg Ser Asn Ile Gln Gly Phe Lys Ala Lys Val Val Arg Asp Pro Glu 
        275                 280                 285             


Lys Pro Ile Asp Phe Lys Asn Asn Ser Leu Lys Tyr Met Ala Thr His 
    290                 295                 300                 


Trp Val Phe Asn His Leu Ala Ala Lys Pro Ile Lys Glu Arg Leu Asn 
305                 310                 315                 320 


Thr Ala Phe Gln Lys Glu Thr Leu Leu Leu Gln Ile Ala Asp Glu Leu 
                325                 330                 335     


Ser Lys Val Pro Asp Glu Val Tyr Gln Thr Phe Ser Gln Glu Lys Lys 
            340                 345                 350         


Asn Glu Phe Leu Glu Asp Ile Asn Glu Tyr Phe Lys Thr Gly Asn Asp 
        355                 360                 365             


Ile Lys Ser Phe Glu Glu Ser Arg Val Val His Pro Val Ile Arg Lys 
    370                 375                 380                 


Arg Tyr Glu Asn Lys Phe Asn Tyr Phe Val Leu Arg Phe Leu Asp Glu 
385                 390                 395                 400 


Phe Ile Asp Phe Pro Thr Leu Arg Phe Gln Ile His Leu Gly Asn Tyr 
                405                 410                 415     


Val His Asp Gln Lys Glu Lys Pro Ile Ser Gln Gly Thr His Leu Ile 
            420                 425                 430         


Thr Gln Arg Ile Ile Lys Glu Lys Ile Asn Leu Phe Gly Lys Leu Ser 
        435                 440                 445             


Glu Val Thr Asn Asn Lys Thr Asp Phe Phe Gln Lys Leu Glu Val Ala 
    450                 455                 460                 


Gly Gly Glu Thr Asn Leu Glu Met Phe Pro Glu Pro Ser Tyr Asn Phe 
465                 470                 475                 480 


Val Gly Asn Asn Ile Pro Ile Tyr Leu Asn Leu Ala Lys Ser Lys Val 
                485                 490                 495     


Glu Gly Ala Lys Glu Leu Asn Ser His Leu Ile Arg Leu Asn Asn Glu 
            500                 505                 510         


Glu Lys Lys His Gln Lys Lys Arg Thr Gly Asn Lys Pro Asp Lys Thr 
        515                 520                 525             


Ala Ile Leu Ser Glu Ile Gln Ile Ser Gly Ile Ser Tyr Gly Lys Pro 
    530                 535                 540                 


Val Ala Leu Leu Ser Leu Asn Glu Leu Pro Ala Leu Leu Tyr Glu Leu 
545                 550                 555                 560 


Leu Ile Asn Gly Lys Ser Gly Glu Glu Ile Glu Asn Ile Leu Val Glu 
                565                 570                 575     


Lys Leu Val Ala Arg Tyr Lys Thr Ile Asn Asn Phe Ser Pro Asp Asn 
            580                 585                 590         


Pro Leu Pro Thr Ser Gln Ile Ser Lys Lys Leu Arg Lys Ala Thr Ala 
        595                 600                 605             


Asn Glu Arg Ile Asp Ile Asp Lys Leu Ile Arg Ala Ile Asp Arg Glu 
    610                 615                 620                 


Ile Thr Val Ser Lys Glu Lys Ala Asn Leu Ile Ala Thr Lys Leu Arg 
625                 630                 635                 640 


Asp Trp Glu Asn Ala Lys Thr Asn Arg Lys Tyr Val Phe Thr Lys Lys 
                645                 650                 655     


Glu Leu Gly Gln Glu Ala Thr Trp Leu Ala Asp Asp Ile Lys Arg Phe 
            660                 665                 670         


Met Pro Asn Lys Ile Lys Glu Asn Trp Lys Gly Tyr Gln His Ser His 
        675                 680                 685             


Leu Gln Leu Leu Leu Thr Phe Tyr Glu Ser Arg Pro Asn Glu Ala Tyr 
    690                 695                 700                 


Ser Phe Leu Arg Glu Phe Trp Asn Leu Asp Asp Asp Thr Tyr Leu Phe 
705                 710                 715                 720 


Asn Arg Trp Leu Lys Thr Ser Phe Asn Glu Lys Ser Phe His Lys Phe 
                725                 730                 735     


Tyr Leu Lys Tyr Leu Glu Asn Arg Lys Glu Tyr Phe Glu Asn Ile Gln 
            740                 745                 750         


Gln Gln Ile Thr Ala Phe Lys Asn Gln Glu Lys Leu Leu Lys Lys Phe 
        755                 760                 765             


Ile Glu Gln Gln His Ile Trp Ser Val Phe Tyr Lys Arg Leu Tyr Ile 
    770                 775                 780                 


Val Ser Pro Ile Glu Glu Gln Lys Arg Gln Leu Leu Leu Lys Pro Leu 
785                 790                 795                 800 


Val Phe Thr Arg Gly Ile Phe Asp Pro Lys Pro Thr Tyr Ile Glu Gly 
                805                 810                 815     


Lys Glu Phe Glu Gly Asn Lys Asp Leu Phe Ala Asp Trp Tyr Gln Tyr 
            820                 825                 830         


Ile His Asp Glu Glu His Val Leu Gln Lys Phe Tyr Ser Trp Lys Arg 
        835                 840                 845             


Asp Tyr Lys Glu Leu Phe Glu Lys Phe Lys Ala Ser Asp Glu Phe Thr 
    850                 855                 860                 


Asn Asn Lys Tyr Gln Leu Ser Glu Lys Gln Gln Phe Glu Leu Phe Asn 
865                 870                 875                 880 


Arg Lys Trp Asp Lys Lys Ile Arg Lys Ile Ile Gly Gln Asp Leu Phe 
                885                 890                 895     


Leu Asn Leu Ile Ile Lys Arg Ile Ile Lys Glu Leu Tyr His Gln Asp 
            900                 905                 910         


Val Ala Leu Asn Leu Ala Asp Tyr Tyr Leu Thr Gln Glu Glu Arg Ile 
        915                 920                 925             


Glu Lys Glu Gln Arg Ala Lys Gln Gln Thr Asn Arg Leu Lys Gly Asp 
    930                 935                 940                 


Lys Ser Glu Asn Ile Ile Asn Asp Ser Phe Ile Trp Asn Met Thr Ile 
945                 950                 955                 960 


Ser Tyr Lys Thr Asp Tyr Ile Asp Glu Pro Ala Ile Lys Leu Lys Asp 
                965                 970                 975     


Ile Gly Lys Phe Ile Arg Phe Leu Asn Asp Glu Lys Val Glu Arg Ile 
            980                 985                 990         


Phe Ser Tyr Thr Pro Lys Lys Asn  Asn Trp Arg Lys Asp  Lys Ile Glu 
        995                 1000                 1005             


Lys Glu  Leu Glu Met Tyr Glu  Lys Ile Arg Arg Glu  Glu Val Phe 
    1010                 1015                 1020             


Lys Met  Ile Gln Glu Leu Glu  Lys Lys Ile Leu Glu  Lys His Lys 
    1025                 1030                 1035             


Phe Asp  Gly Ile Asn His Pro  Asp Glu Phe Glu Lys  Ser Gly Asn 
    1040                 1045                 1050             


Pro Asn  Phe Lys Lys Tyr Ile  Ala Gln Gly Val Leu  Lys Lys His 
    1055                 1060                 1065             


Gly Ile  Gln Asp Val Val Ile  Glu Trp Ile Glu Asn  Leu Gly Glu 
    1070                 1075                 1080             


Asn Ser  Tyr Glu Asp Asn Asn  Thr Leu Glu Leu Leu  Val Gln Lys 
    1085                 1090                 1095             


Asp Lys  Lys Val Gln Asp Ala  Phe Leu Leu Ile Tyr  Leu Arg Asn 
    1100                 1105                 1110             


Lys Phe  Ala His Asn Gln Leu  Pro Thr Lys Glu Ile  Phe Asp Ile 
    1115                 1120                 1125             


Ile Val  Ser Lys Thr Asp Thr  Lys Ser Tyr Val Ala  Glu Thr Leu 
    1130                 1135                 1140             


Leu Asn  Tyr Ile Ser Ile Thr  Ser Arg Arg Ile Leu  Asn 
    1145                 1150                 1155     


<210>  1709
<211>  1502
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1709

Met Gly Lys Gly Lys Lys Gly Asn Ala Asn Lys Gln Pro Lys Gln Gln 
1               5                   10                  15      


Val Ile Arg Phe Ser Val Lys Gln Phe Ser Ile Lys Glu Gly Asp Lys 
            20                  25                  30          


Lys Ile Tyr Gly Gly Tyr Phe Asn Met Gly Leu Cys Asn Tyr Tyr Lys 
        35                  40                  45              


Ala Ile Ser His Ile Phe Ser Val Leu Gly Ile Arg Gln Ile Val Thr 
    50                  55                  60                  


Thr Lys Phe Asn Asp Glu Tyr Val Lys Val Pro Met Tyr Ser Glu Glu 
65                  70                  75                  80  


Asn Leu Tyr Val Val Leu Arg Tyr Phe Lys Lys Phe Ile Asp Asp Arg 
                85                  90                  95      


Thr Gln Glu Glu Ser Ile Lys Lys Lys Ile Gln Ser Ala Leu Arg Leu 
            100                 105                 110         


Lys Ser Gln Asp Gln Glu Leu Gln Lys Ile Asn Asp Glu Glu Leu Asp 
        115                 120                 125             


Asp Leu Met Lys Ser Leu His Leu Thr Asn Glu Gln Leu Val Lys Phe 
    130                 135                 140                 


Gln Gln Leu Leu Phe Lys His Phe Pro Val Leu Gly Pro Ile Met Ala 
145                 150                 155                 160 


Asp Val Val Ser Lys Asn Val Asn Asp Glu Val Lys Lys Ala Ile Glu 
                165                 170                 175     


Gly Glu Asp Asp Glu Lys Val Ile Asn Arg Lys Lys Ser Lys Val Ile 
            180                 185                 190         


Gln Ser Tyr Asp Asn Leu Arg Gly Val Thr Leu Ser Gln Cys Leu Glu 
        195                 200                 205             


Glu Val Ala Asn Leu Gly Glu Cys Leu Lys Asp Cys Arg His Tyr Tyr 
    210                 215                 220                 


Thr His Tyr Arg Pro Tyr Asn Ser Gln Asn Thr Gln Lys Lys Ile Phe 
225                 230                 235                 240 


Asp Arg Gln Tyr Glu Val Ala Lys Lys Leu Asn Lys Val Leu Thr Ala 
                245                 250                 255     


Ser Arg Arg Ile Asp Lys Arg Arg Asn Ala Leu Thr Ser Glu Gln Met 
            260                 265                 270         


Glu Phe Leu Thr Gly Thr Asp His Phe Lys Lys Val Asp Lys Lys Phe 
        275                 280                 285             


Ile Glu Arg Glu Ser Phe Tyr Phe Asn Leu Lys Gly Gln Arg Ile Ala 
    290                 295                 300                 


Ser Thr Thr Ser Lys Asp Gln Glu Gly Ile Val Thr Thr Ile Ser Thr 
305                 310                 315                 320 


Thr His Arg Ala Leu Ser Asp Phe Gly Ile Ala Tyr Phe Cys Ala Thr 
                325                 330                 335     


Phe Leu Ser Lys Thr Tyr Glu Arg Lys Phe Leu Asp Glu Ile Lys Leu 
            340                 345                 350         


Leu Lys Thr Ser Pro Leu Leu Phe Asp Ile Pro Ala Ser Asp Glu Asn 
        355                 360                 365             


Leu Lys Lys Val Ser Met Gln Glu Leu Ser Asp Ala Asp Ile Ala Asn 
    370                 375                 380                 


His Phe Arg Gln Tyr Cys Lys Leu Gln Asn Ile Asn Asp Asn Asn Ile 
385                 390                 395                 400 


Ala Asn Tyr Val Lys Thr Phe Ile Gly Asp Leu Phe Asn Lys Asn Glu 
                405                 410                 415     


Asp Gly Thr Ile Asn Tyr Ser Asp Thr Pro Lys Gly Val Ile Arg Val 
            420                 425                 430         


Tyr Ile Gly Asn Pro Leu Ser Glu Gln Glu Asn Lys Leu Met Glu Glu 
        435                 440                 445             


Ile Leu Ala Val Tyr Arg Val Arg Thr Pro Arg Gly Lys Arg Leu Asp 
    450                 455                 460                 


Ser Gln Ser Asn Ser Ile Thr Leu Gly Met Asp Met Leu Asn Glu Leu 
465                 470                 475                 480 


Arg Lys Cys Pro Met Glu Leu Tyr Asp Thr Leu Pro Ile Glu Gly Gln 
                485                 490                 495     


Lys Phe Phe Glu Asp Lys Val Lys Arg Glu Asn Glu His Thr Pro Glu 
            500                 505                 510         


Ile Val Lys Arg Leu Arg Ser Lys Asp Arg Phe Ala Glu Leu Ala Leu 
        515                 520                 525             


His Tyr Ile Asp Glu Gln Lys Lys Phe Asn Asp Val Asn Ile Arg Phe 
    530                 535                 540                 


Gln Ile Arg Leu Gly Ser Phe Arg Tyr Lys Phe Tyr Asp Lys Ile Cys 
545                 550                 555                 560 


Val Asp Gly Glu Glu Arg Val Arg Arg Ile Gln Lys Glu Val Asn Gly 
                565                 570                 575     


Tyr Gly Arg Ile Gln Asp Val Glu Thr Glu Arg Lys Lys Lys Trp Glu 
            580                 585                 590         


Asp Asp Leu Gln Lys Ala Asn Thr Gln Ser Val Lys Leu Glu His Glu 
        595                 600                 605             


Asp Leu Tyr Leu Asp Leu Leu Gln Phe Glu Lys Asp His Lys Asp Ser 
    610                 615                 620                 


Thr Pro Tyr Ile Thr Asp Arg Arg Ala Glu Tyr Asn Ile His Arg Asn 
625                 630                 635                 640 


Arg Ile Gly Met Leu Trp Asn Gln Asp Ser Glu Glu Lys Lys Tyr Leu 
                645                 650                 655     


Gln Asp Glu Gly Leu Tyr Tyr Leu Pro Glu Leu Thr Val Thr Gly Glu 
            660                 665                 670         


Asn Asp Asn Arg Lys Ser Pro Leu Asp Met Pro Ala Pro Leu Cys Ser 
        675                 680                 685             


Ile Ser Ile Tyr Glu Leu Pro Ala Met Leu Phe Tyr Gln Tyr Leu Gln 
    690                 695                 700                 


Glu Asn Tyr Asn Asp Ser Asn Gly Lys Glu Tyr Tyr Thr Thr Glu Gln 
705                 710                 715                 720 


Ile Ile Lys Thr Lys Tyr Asp Gly Leu Val Lys Phe Phe Thr Asp Ile 
                725                 730                 735     


Lys Asn Gly Met Phe Val His Gln Pro Asp Glu Lys Ser Leu Lys Ile 
            740                 745                 750         


His Leu Glu Lys Thr Tyr Lys Leu Phe Leu Thr Asp Ile Pro Val Lys 
        755                 760                 765             


Leu Arg Gln Tyr Ile Thr Asp Glu Met Pro Glu Glu Thr Pro Met Glu 
    770                 775                 780                 


His Leu Leu Asp Leu Thr Ile Gly Glu Lys Lys Asp Leu Gly Arg Leu 
785                 790                 795                 800 


Ile Pro Arg Ile Lys Arg Leu Glu His Arg Arg Asp Thr Tyr Lys Gln 
                805                 810                 815     


Asp Arg Glu Lys Ile Gly Asp Lys Thr Asn Asn Tyr Gly Lys Lys Ser 
            820                 825                 830         


Phe Val Asp Val Arg His Gly Ser Leu Ala Lys Phe Leu Val Arg Asp 
        835                 840                 845             


Ile Val Gly Trp Gln Gly Ser Lys Asn Asn Gly Arg Asp Lys Leu Thr 
    850                 855                 860                 


Gly Leu Asn Tyr Thr Ala Ile Gln Ala Phe Leu Ser Val Tyr Gly Gln 
865                 870                 875                 880 


Lys Asp Glu Tyr Gly Cys Lys Glu Leu Glu Glu Met Leu Arg Arg Ser 
                885                 890                 895     


Asn Leu Leu Lys Gln Arg Tyr Gln Ser Leu Pro Lys Asp Lys Asp Lys 
            900                 905                 910         


Arg Arg Gly Leu Lys Lys Tyr Asp Ser Gln Leu Glu Asn Asn Pro Ile 
        915                 920                 925             


Ala His Pro Phe Leu Asp Ala Val Leu Gln Cys Ser Pro Arg Asn Ile 
    930                 935                 940                 


Glu Glu Phe Tyr Leu Phe Tyr Leu Asp Glu Glu Ile Lys Lys Leu Lys 
945                 950                 955                 960 


Ser Leu Ala Glu Asn Leu Ile Lys Ala Lys Asn Gln Glu Ala Ser Leu 
                965                 970                 975     


Asn Asn Ile Pro Phe Ile His Thr Asn Arg Val Lys Tyr Gln Asp Arg 
            980                 985                 990         


Thr Ser Glu Glu Ala Ile Arg Gln  Leu Ala Ala Arg Tyr  Leu Glu Ile 
        995                 1000                 1005             


Ser Asp  Lys Asp Ala Asn Gly  Ser Pro Val Lys His  Arg Ala Thr 
    1010                 1015                 1020             


Ile Leu  Leu Pro Asp Gly Met  Phe Val Asn Tyr Ile  His Thr Ile 
    1025                 1030                 1035             


Leu Ala  Asp Asn Phe Lys Asp  Asn Lys Glu Phe Ile  Lys Ala Ile 
    1040                 1045                 1050             


Ser His  Gln Asp Asn Pro Ala  Thr Tyr Lys Gln Asn  Gly Lys His 
    1055                 1060                 1065             


Asp Asn  Ser Asn Lys Asn Ala  Ala His His Ile Thr  Gln Phe Phe 
    1070                 1075                 1080             


Glu Lys  Ile Leu Gly Asp His  Ser Gln Glu Tyr Tyr  Tyr Ala Lys 
    1085                 1090                 1095             


Asp Ser  Arg Gln Ile Ile Glu  Glu Asp Asp Ala Tyr  Gly Asp Arg 
    1100                 1105                 1110             


Ala Ile  Gln Arg Lys Gly Asp  Tyr Asp Arg Phe Ala  Arg Asn Tyr 
    1115                 1120                 1125             


Asp Ile  Phe Lys Leu Leu His  Asp His Ile Lys Gly  Ala Glu Val 
    1130                 1135                 1140             


Met Pro  Tyr Tyr Leu Ser Pro  Gln Gln Ile Asn Asp  Gln Ile Ser 
    1145                 1150                 1155             


Lys Arg  Ala Lys Asp Lys Leu  Gly Lys Asp Ile Pro  Leu Glu Asn 
    1160                 1165                 1170             


Lys Val  Thr Thr Asp Gly Ala  Pro Arg Phe Leu Lys  Glu Ile Gln 
    1175                 1180                 1185             


Leu Arg  Ile Asp Arg Leu Val  Asn Lys Lys Arg Gln  Asn Ala Ile 
    1190                 1195                 1200             


Asn Lys  Ala Leu His Pro Lys  Phe Gly Lys Pro Lys  Lys Pro Asn 
    1205                 1210                 1215             


Tyr Gln  Lys Leu Asp Ile Ala  Asp Glu Glu Leu His  Glu Arg Leu 
    1220                 1225                 1230             


Glu His  Ala Ile Leu Phe Cys  Lys Glu Asn Glu Lys  Ala Ile Arg 
    1235                 1240                 1245             


Arg Tyr  Lys Thr Gln Asp Met  Val Leu Phe Leu Leu  Ala Lys Gln 
    1250                 1255                 1260             


Leu Ile  Glu Asn Ala Ile Gln  Ser Glu Asp Ser Ser  Asp Cys Ser 
    1265                 1270                 1275             


Glu Lys  Phe Lys Leu Gly Asn  Ile Cys Lys Asp Asn  Phe Leu Lys 
    1280                 1285                 1290             


Gln Thr  Val Arg Tyr Glu Phe  Pro Val Thr Thr Ser  Asp Gly His 
    1295                 1300                 1305             


Thr Val  Lys Val Thr Gln Pro  Asn Met Ser Leu Lys  Asn Tyr Gly 
    1310                 1315                 1320             


Glu Phe  Tyr Arg Leu Leu Ser  Asp Glu Arg Phe Ile  Ser Met Leu 
    1325                 1330                 1335             


Glu Gln  Leu Lys Asp Ile Asp  Val Ile Asn Tyr Asn  Lys Leu Met 
    1340                 1345                 1350             


Ala Glu  Leu Val Thr Tyr Asp  Asn Tyr Arg Ser Glu  Ile Phe Gly 
    1355                 1360                 1365             


Val Ile  His Lys Val Glu Glu  Asn Ile Tyr Lys Gln  Lys Glu Ile 
    1370                 1375                 1380             


Ile His  Asp Glu Asn His Asp  Leu Asp Glu Phe Tyr  Ile Asp Asn 
    1385                 1390                 1395             


Asp Lys  Asn Lys Met Ala Lys  Arg Asn Asn Phe Ser  Glu Met Leu 
    1400                 1405                 1410             


Glu Leu  Leu Lys Asp Val Asp  Thr Ser Lys Leu Thr  Lys Glu Glu 
    1415                 1420                 1425             


Arg Ser  Met Phe Val Lys Ile  Arg Asn Ala Phe Ser  His Asn His 
    1430                 1435                 1440             


Met Arg  Ile Pro Phe Arg Asn  Trp Met Thr Glu Asp  Glu Arg Glu 
    1445                 1450                 1455             


Glu Tyr  Lys Glu Trp Met Ala  Lys Asp Asp Val Pro  Lys Glu Lys 
    1460                 1465                 1470             


Gln Gln  Gly Arg Ile Ala Pro  Pro Asn Ile Ser Asp  His Ile Leu 
    1475                 1480                 1485             


Lys Lys  Ala Asn Glu Leu Lys  Lys Lys Ser Gly Cys  Glu Ser 
    1490                 1495                 1500         


<210>  1710
<211>  1519
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1710

Met Ala Thr Phe Arg Phe Gln Asn Lys Tyr Val Cys Gly Ala Tyr Tyr 
1               5                   10                  15      


Asn Met Ala Gln Asn Asn Phe Arg Leu Ala Ile Leu His Val Leu Ser 
            20                  25                  30          


Arg Ile Gly Ile Asn Arg Lys Asp Glu Glu Arg Ala Ile Pro Glu Leu 
        35                  40                  45              


Leu Asp Thr Ile Tyr Gly Phe Leu Thr Gly Asp Thr Glu His Phe Asn 
    50                  55                  60                  


Asp Thr Gln Ile Leu Gln Lys Lys Val Leu Thr Leu Arg Tyr Asp Gln 
65                  70                  75                  80  


Gln Val Lys Leu Arg Glu Leu Leu Phe Arg Gln Phe Pro Ile Leu Lys 
                85                  90                  95      


Pro Ile Ile Ala Ser Glu Thr His Lys Ser Leu Gln Glu Gln Lys Glu 
            100                 105                 110         


Lys Leu Ser Glu Met Glu Glu Tyr Ile His Glu Phe Glu Lys Gln Leu 
        115                 120                 125             


Lys Arg Leu Tyr Arg Ser Lys Lys Gly Lys Ala Ser Gln Glu Gln Lys 
    130                 135                 140                 


Glu Ile Asn Glu Gln Ile Lys Tyr Leu Lys Thr Lys Lys Ser Lys Tyr 
145                 150                 155                 160 


Leu Asp Glu Tyr Asp Thr Leu Leu Phe Ser Lys Ser His Asp Ala Asp 
                165                 170                 175     


Leu Gln Leu Cys Leu Lys Ile Leu Lys Thr Met Ala Trp Cys Leu Tyr 
            180                 185                 190         


Asp Leu Arg Asp Phe Tyr Thr His Tyr Asp Pro Tyr Asn Thr Pro Glu 
        195                 200                 205             


Ser Leu Lys Val Lys Tyr Leu Arg Gln Val Thr Val Ala Asn Trp Leu 
    210                 215                 220                 


Ser Gln Val Phe Ala Ala Ser Arg Thr Ile Asp Lys Glu Arg Asn Ser 
225                 230                 235                 240 


Ile Thr Thr Glu Glu Met Asn Phe Leu Asn Glu Ala Lys Lys Gln Gly 
                245                 250                 255     


Asn Asp Lys Lys Trp Arg Glu Asp Pro Asp Tyr Tyr Phe Ala Ile Lys 
            260                 265                 270         


Gly Gln Asn Leu Leu Ser Ser Ser Phe Ile Asp Ala Asp Ser Pro Val 
        275                 280                 285             


Tyr Asn Asp Tyr Leu Asp Glu Leu Tyr Gln Lys Tyr Arg Lys Lys Arg 
    290                 295                 300                 


Leu Ala Trp Met Lys Glu Gln Arg Asp Glu Ala Leu Glu Arg Asp Asp 
305                 310                 315                 320 


Glu Glu Glu Tyr Gly Phe Trp Val Val Glu Met Glu Lys Leu Asp Asn 
                325                 330                 335     


Pro Glu Arg Ile Ala Lys Ile Lys Ser Lys Ile Cys Pro Leu Ala Leu 
            340                 345                 350         


Ser Asp Phe Gly Val Leu Tyr Phe Cys Ala Thr Phe Leu Pro Arg Asn 
        355                 360                 365             


Tyr Thr Leu Leu Met Ala Asp His Ala Glu Val Met Lys Asn Ser Pro 
    370                 375                 380                 


Tyr Ser Met Thr Ala Glu Glu Leu Glu Ala Arg Arg Asn Ala Cys Lys 
385                 390                 395                 400 


Thr Asp Glu Glu Arg Glu Lys Ile Asp Pro Thr Asp Thr Pro Arg Asn 
                405                 410                 415     


Asn Ile Leu Arg Glu Met Leu Cys Ile Tyr Arg Val Arg Leu Pro Lys 
            420                 425                 430         


Gly Lys Arg Leu Asp Lys Lys Asp Thr Lys Gly Leu Leu Thr Leu Asp 
        435                 440                 445             


Ile Leu Asn Glu Leu Arg Lys Cys Pro Lys Glu Val Tyr Glu Gln Leu 
    450                 455                 460                 


Ser Lys Glu Gly Lys Asp Phe Phe Ile Ser Arg Val Ser Ser Ala Ser 
465                 470                 475                 480 


His Asn Ala Pro Asp Ile Val Lys Arg Ile Arg Phe Gly Asp Arg Phe 
                485                 490                 495     


Pro Tyr Leu Ala Leu Arg Ala Ile Asp Glu Ser Asp Val Phe Lys Arg 
            500                 505                 510         


Ile Arg Phe Gln Val Arg Leu Gly Ser Tyr Arg Phe Tyr Phe Tyr Asn 
        515                 520                 525             


Lys Thr Cys Ile Asp Gly Ser Thr Gln Leu Arg Arg Trp Gln Lys Glu 
    530                 535                 540                 


Ile Asn Gly Phe Gly Arg Leu Gln Asp Met Glu Ala Leu Arg Lys Ser 
545                 550                 555                 560 


Leu Trp Lys Asp Leu Leu Gln Lys Lys Glu Tyr Asp Ser Val Gln Leu 
                565                 570                 575     


Glu Asp Lys Ser Gly Tyr Leu Asp Leu Gln Gln Phe Lys Ala Asp Ala 
            580                 585                 590         


Pro Asp Ser Val Pro Tyr Ile Thr Asp Ser Gln Ala Gln Tyr Asn Ile 
        595                 600                 605             


His Asn Asn Arg Ile Gly Leu Ile Trp Asn Gly Asp Glu Cys Arg Leu 
    610                 615                 620                 


Leu Arg Asn Ile Lys Asp Ala Asp Val Leu Arg Glu Tyr Val Tyr Leu 
625                 630                 635                 640 


Pro Asp Leu Lys Asp Asn Asp Gly Asn Pro Lys Lys Ser Gly Lys Asp 
                645                 650                 655     


Ile Glu Gln Pro Ser Pro Leu Cys Ser Leu Ser Thr Tyr Glu Leu Pro 
            660                 665                 670         


Ala Leu Leu Phe Tyr His Phe Leu Tyr Asn Thr Pro Glu Ala Gln Val 
        675                 680                 685             


His Lys Glu Arg Leu Glu Lys Pro Glu Gln Val Ile Ile Lys Lys Tyr 
    690                 695                 700                 


Glu Ala Leu Arg Ala Phe Phe Leu Glu Leu Arg Ser His Pro Glu Gln 
705                 710                 715                 720 


Ile Val Lys Thr Asp Leu Gln Ala Thr Leu Thr Arg Phe Gly Leu Lys 
                725                 730                 735     


Cys Ser Glu Ile Pro Gln Arg Ile Ile Asp Cys Ile Gln Gly Cys Gln 
            740                 745                 750         


Gln Lys Gln Lys Glu Thr Glu Ser Ser Val Thr Tyr Leu Pro Asp Leu 
        755                 760                 765             


Leu Gln Leu Pro Met Glu Asp Ile Arg Gln Lys Val Gln Glu Lys Gly 
    770                 775                 780                 


Met Glu Arg Tyr Lys Asp Leu Pro Ala Lys Phe Arg Lys Gln Ile Ser 
785                 790                 795                 800 


His Glu Gln Ile Val Thr Ser Gly Leu Glu Thr Leu Leu Lys Pro Leu 
                805                 810                 815     


Gly Ile Ser Val Glu Ser Leu Pro Ala Lys Val Met Glu Ala Leu Leu 
            820                 825                 830         


Ser Thr Gln Ile Gln Glu Asp Val Ala Pro Ala Glu Asp Ala Ser Thr 
        835                 840                 845             


Glu Lys Pro Phe Asn Ile Met Phe Val Arg Ser Val Val Tyr Lys Leu 
    850                 855                 860                 


His Glu Arg Leu Gln Asp Val Ser Lys Arg His Gln Ser Phe Val Glu 
865                 870                 875                 880 


Ser Ile His Arg Val Gly Ser Lys Asp Asn Lys Phe Ala Lys His Gly 
                885                 890                 895     


Tyr Met Asp Val Arg His Gly Lys Leu Ala Glu Tyr Leu Ala Gly Ser 
            900                 905                 910         


Phe Leu Lys Trp Gln Pro Thr Ile Ser Asn Gly Ser Asp Lys Leu Thr 
        915                 920                 925             


Gly Leu Asn Tyr Asn Val Leu Lys Ser Phe Leu Ser Thr Tyr Gly Ile 
    930                 935                 940                 


Ala Thr Asp Ile Asp Asp Leu Thr Ala Val Leu His Glu Ala Lys Leu 
945                 950                 955                 960 


Ile His Leu Gly Lys Glu Glu Thr Pro Ile Pro His Pro Phe Leu Gln 
                965                 970                 975     


Lys Val Ile Asp Lys Glu Pro Asp Asn Leu Glu Lys Leu Phe His Leu 
            980                 985                 990         


Tyr Ile Ile Gln Glu Lys Glu Tyr  Leu Ser Asp Leu Leu  Ile Asp Tyr 
        995                 1000                 1005             


Leu Leu  Gln Ile Ser Thr Ala  Ile Gly Thr Glu Gly  Gln Asp Ala 
    1010                 1015                 1020             


Asp Met  Leu Glu Glu Ala Tyr  Thr Cys Asn Gly Glu  Lys Leu Ile 
    1025                 1030                 1035             


Ser Asp  Met Leu Glu Glu Tyr  Glu Ala Lys Ser Thr  Ala Asp Ser 
    1040                 1045                 1050             


Arg Gln  Ser Val Tyr Gln Leu  Glu His Pro Ala Phe  Thr His Pro 
    1055                 1060                 1065             


Lys Arg  Glu Arg Trp Lys Gln  Gly Thr Asn Ile Ala  Thr Leu Thr 
    1070                 1075                 1080             


Gln Leu  Ala Lys Ser Tyr Thr  Asn Pro Leu Leu Leu  Pro Asp Gly 
    1085                 1090                 1095             


Leu Phe  Thr Glu Ala Ile Arg  His Leu Met Glu Ile  Val Tyr Ser 
    1100                 1105                 1110             


Asp Asn  Gln Lys Leu Gln Asp  Glu Leu Ser Arg Gln  Asn Ser Lys 
    1115                 1120                 1125             


Gly Glu  Ala Ala Ser His Ser  Val Ala Phe Ile Ile  Asp Val Tyr 
    1130                 1135                 1140             


Ser Arg  Ile Val Leu Asn Asp  His Val Gln Ser Tyr  Tyr Cys Ser 
    1145                 1150                 1155             


Asp Leu  Val Gln Pro Glu Cys  Thr Asn Phe Ala Arg  Ser Tyr Arg 
    1160                 1165                 1170             


Leu Phe  Asp Lys Leu Asn Asn  Gln Lys Asp Pro Phe  Lys Ala Phe 
    1175                 1180                 1185             


Val Arg  Val Pro Met Asp Thr  Ile Gly Ile Met Gln  Lys Leu Lys 
    1190                 1195                 1200             


Thr Gly  Lys Glu Gln Phe Glu  Ala Glu Val Glu Thr  Tyr Ile Ile 
    1205                 1210                 1215             


Asp Thr  Glu Arg Arg Glu Lys  Ala Glu Ala Glu Gln  Lys Val Arg 
    1220                 1225                 1230             


Asn Lys  Ser Val Arg Glu Asn  Trp Lys Leu Asp Arg  Tyr Glu Gln 
    1235                 1240                 1245             


Glu Arg  Glu Arg Ala Ile Asp  Asn Ala Ser Trp Pro  Asp Ser Lys 
    1250                 1255                 1260             


Lys Gln  Glu Glu Arg Asp Lys  Met Glu Arg Met Lys  Arg Phe Val 
    1265                 1270                 1275             


Gln Lys  Asn Glu Arg Ala Ile  Arg Arg Tyr Arg Ile  Gln Asp Ile 
    1280                 1285                 1290             


Thr Leu  Phe Leu Met Ala Arg  Asn Met Leu Ser Glu  Val Phe Ser 
    1295                 1300                 1305             


Gly Asp  Asp Gly Gln Ser Phe  Asp Glu Gln Ser Arg  Gln Asn Leu 
    1310                 1315                 1320             


Lys Leu  Glu Asn Val Cys Asn  Glu Asp Phe Leu Ser  Gln Thr Ile 
    1325                 1330                 1335             


Asp Tyr  Glu Tyr Ala Tyr Gln  Leu Gly Asp Arg Thr  Val Thr Ile 
    1340                 1345                 1350             


Arg Gln  Ala Gly Met Ser Leu  Lys Asn Tyr Gly Gln  Phe Tyr Arg 
    1355                 1360                 1365             


Phe Leu  Gly Asp Val Arg Leu  Asp Thr Leu Leu Met  Leu Leu Ala 
    1370                 1375                 1380             


Asn Val  Lys Ser Val Thr Leu  Thr Asp Val Ala Ser  Glu Phe Ala 
    1385                 1390                 1395             


Lys Tyr  Asp Gln Glu Arg Pro  Leu Ala Phe Lys Lys  Leu Gln Leu 
    1400                 1405                 1410             


Leu Glu  Gln Leu Ala Ile Glu  Thr Asp Gln Thr Gly  Thr Leu Tyr 
    1415                 1420                 1425             


Asn Pro  Glu Ala Asp Gly Phe  Ser Phe Ile Asn Pro  Lys Gly Gln 
    1430                 1435                 1440             


Lys Glu  Pro Lys Arg Asn Asn  Phe Ala Lys Leu Leu  Asp Leu Leu 
    1445                 1450                 1455             


Lys Asp  Leu Gly Ser Asp Lys  Asn Lys Leu Leu Thr  Asp Ile Arg 
    1460                 1465                 1470             


Asn Ala  Leu Gly His Asn Lys  Tyr Ile Thr Asp Ser  Ser Ala Met 
    1475                 1480                 1485             


Thr Leu  Asn Glu Gln Leu Glu  Ile Thr Gln Val Ala  Val Lys Met 
    1490                 1495                 1500             


Ser Glu  Gln Ile Ser Leu Leu  Gln Gln Gly Ile Gln  Glu Asn Ile 
    1505                 1510                 1515             


Lys 
    


<210>  1711
<211>  1324
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1711

Met Ala Thr Phe Arg Phe Thr Asp Lys Ser Val Ser Ala Thr Tyr Tyr 
1               5                   10                  15      


Asn Met Ala Arg Asp Asn Phe His Gln Thr Met Val Glu Ile Leu Ser 
            20                  25                  30          


Lys Val Gly Val Lys Gly Glu Met Glu Gln Lys Ile Asp Asn Gln Leu 
        35                  40                  45              


Asp Glu Leu Gln Lys Asp Leu Glu Asn Pro Gln Lys Glu Ser Lys Phe 
    50                  55                  60                  


Lys Leu Ser Asn Glu Lys Gln Val Lys Leu Arg Lys Leu Leu Phe Glu 
65                  70                  75                  80  


His Phe Pro Ile Leu Gly Pro Ile Met Ala Ser Val Leu Phe Arg Asn 
                85                  90                  95      


Leu Asn Lys Ser Asp Asn Lys Gln Leu Gln Thr Lys Lys Ser Asn Val 
            100                 105                 110         


Val Asp Gly Asp Val His Asp Val Ser Leu Ser Glu Cys Leu Lys Val 
        115                 120                 125             


Leu Val Val Leu Ala Lys Cys Leu Thr Asp Thr Arg Asn Tyr Phe Thr 
    130                 135                 140                 


His Tyr Asn Pro Phe Asn Ser Gln Glu Ala Leu Cys Lys Met Tyr Glu 
145                 150                 155                 160 


Arg Gln Lys Lys Val Ser Ala Tyr Leu Asp Gln Val Phe Thr Ala Ser 
                165                 170                 175     


Arg Arg Ile Asn Lys Asn Arg Lys Gly Leu Thr Ser Val Glu Met Gln 
            180                 185                 190         


Phe Ile Thr Ser Glu Ala Tyr Lys Ala Leu Lys Asp Asp Asn Asp His 
        195                 200                 205             


Phe Ile Leu Asp Glu Lys Gly Arg Lys Lys Ile Gly Lys Asn Arg Asp 
    210                 215                 220                 


Tyr Tyr Phe Ser Ile Val Gly Glu Ser Phe Ile His Lys Glu Asp Ala 
225                 230                 235                 240 


Gln Phe Ile Gln Lys Val Phe Asp Gly Val Gln Ile Phe Glu Ala Asp 
                245                 250                 255     


Ser Lys Asn Asn Ala Leu Ser Asp Phe Gly Leu Leu Tyr Leu Cys Ser 
            260                 265                 270         


Cys Phe Ile Ser Arg His Tyr Ala Arg Leu Phe Val Asp Lys Ala Gly 
        275                 280                 285             


Leu Phe Thr His Ser Pro Tyr Ser Arg Ile Asn Asn Gly Val Leu Asn 
    290                 295                 300                 


Gln Ala Thr Lys Glu Asn Asn Ile Ile Leu Glu Met Leu Ser Ile Tyr 
305                 310                 315                 320 


Arg Ile Arg Met Phe Lys Gly Asn Arg Leu Asp Ile His Asp Thr Lys 
                325                 330                 335     


Thr Ser Ile Ala Leu Asp Met Leu Asn Glu Leu Asn Arg Cys Pro Met 
            340                 345                 350         


Pro Leu Tyr Glu His Leu Ser Pro Glu Gly Lys Met Ala Phe Glu Asp 
        355                 360                 365             


Lys Val Thr Arg Pro Asn Glu Asn Thr Pro Asp Val Ser Leu Arg Leu 
    370                 375                 380                 


Arg His Thr Asp Arg Phe Pro Thr Leu Ala Leu Lys Met Ile Asp Ala 
385                 390                 395                 400 


Thr Asp Ile Leu Pro Lys Ile Arg Phe Gln Val Gln Leu Gly Thr Tyr 
                405                 410                 415     


Arg Phe Arg Phe Tyr Glu Lys Asp Cys Ile Asp Gly Asn Arg Gln Leu 
            420                 425                 430         


Arg Cys Leu Ser Lys Glu Ile Asn Gly Phe Gly Arg Leu Gln Asp Ile 
        435                 440                 445             


Glu Glu Leu Arg Lys Arg Val Trp Glu Asn Thr Thr Ser Gly Glu Gln 
    450                 455                 460                 


Glu Glu Asn Lys Ile Gln Val Lys Glu Tyr Val Ser Thr Leu Leu Glu 
465                 470                 475                 480 


Asp Glu Glu Thr Thr Leu Asp Leu Leu Gln Pro Leu Gly Asp Lys Pro 
                485                 490                 495     


Gly Asn Asn Pro Tyr Ile Thr Asp His Gln Ala Ser Tyr Asn Ile His 
            500                 505                 510         


Asn Asn Arg Ile Gly Leu Tyr Trp Glu Ser Thr Asn Pro Ala Lys Asn 
        515                 520                 525             


His Tyr Leu Cys Gly Asn Gly Leu Thr Tyr Leu Pro Thr Leu Asn Tyr 
    530                 535                 540                 


Lys Val Val Asp Ser Gly Gly Lys Ile Leu Gln Lys Ala Asp Ile Asp 
545                 550                 555                 560 


Gln Pro Ser Pro Leu Cys Ser Leu Ser Thr Tyr Glu Leu Gly Ser Leu 
                565                 570                 575     


Leu Phe Tyr His Phe Ile Tyr Lys Thr Tyr Gly Gly Lys Lys Leu Gly 
            580                 585                 590         


Met Arg Thr Ala Glu Gln Ile Ile Ile Asp Lys Tyr Asn Asn Leu Ile 
        595                 600                 605             


Arg Phe Phe Lys Glu Ile Glu Ala His Gly Arg Ser Ser Phe Tyr Ala 
    610                 615                 620                 


Thr Val Pro Gly Lys Lys Thr Asp Glu Glu Leu Gln Met Lys Leu Asp 
625                 630                 635                 640 


Asp Tyr Ala Leu Ser Ile Ser Glu Ile Pro Asp Lys Leu Arg Ile Tyr 
                645                 650                 655     


Leu Arg Asn Met Phe Val Thr Tyr Pro Ser Ser Thr Ser Ser Lys Leu 
            660                 665                 670         


Val Gly Glu Arg Leu Val Lys Val Tyr Trp Arg Leu Gln His Phe Lys 
        675                 680                 685             


Glu Asp Arg Lys Lys Ile Gly Asp Lys Asp Asn Lys Tyr Ala Lys Lys 
    690                 695                 700                 


Gly Tyr Ala Asp Ile Arg His Gly Gln Ile Ala Arg Tyr Leu Ala Glu 
705                 710                 715                 720 


Ser Ile Val Asp Trp Leu Pro Glu Ala Ala Arg Ala Arg Thr Ile Leu 
                725                 730                 735     


Thr Gly Leu Asn Phe Asn Lys Leu Gln Ala Ala Leu Ala Thr Phe Asp 
            740                 745                 750         


Gly Ser Glu Gly His Gln Phe Ser Asp Ile Gln Phe Leu Met Arg Gln 
        755                 760                 765             


Ala His Leu Leu Ser Gln Glu Cys Glu Gly Glu Gly Leu Ala Gln Val 
    770                 775                 780                 


Thr Ile Glu Gly His Pro Phe Leu Asn Gln Ile Ile Asp Met Asn Pro 
785                 790                 795                 800 


Gln Asn Ile Glu Val Phe Tyr Ser Arg Tyr Leu Glu His Glu Lys Arg 
                805                 810                 815     


His Leu Thr Lys Phe Leu Glu Val Glu Val Tyr Asn Lys Lys Asn Asn 
            820                 825                 830         


Ser Tyr Lys Tyr Leu Pro Ile Asp Asn Arg Tyr Ile Pro Thr Gly Lys 
        835                 840                 845             


Glu Val Phe Thr Phe Lys Asp Asp Ile Asp Leu Arg Ala Ile Pro Phe 
    850                 855                 860                 


Ile His Pro Asn Arg Asp Lys Trp Lys Lys Arg Asn Asp Val Phe Cys 
865                 870                 875                 880 


Lys Gln Leu Ala Lys Arg Tyr Gln Glu His Ile Glu Leu Pro Asp Gly 
                885                 890                 895     


Leu Phe Thr Arg Glu Val Ile Lys Leu Leu Arg Leu Ala Pro Glu Cys 
            900                 905                 910         


Glu Val Met Phe Asp Asn Gly Phe Lys Glu Glu Asp Cys Asn Met Ser 
        915                 920                 925             


His Leu Val Asn Leu Tyr Leu Glu Arg Val Leu Lys Asp Gln Ser Gln 
    930                 935                 940                 


Ser Tyr Tyr Gly Leu Gly Asp Lys Arg Phe Tyr Arg Ser Tyr Arg Leu 
945                 950                 955                 960 


Phe Asp Ile Leu Tyr Gly Lys Val Val Arg Asn Glu Gln Leu Pro Tyr 
                965                 970                 975     


Tyr Leu Ser Cys Asp Glu Ile Met Glu Lys Ile Gly Ser Lys Glu Gly 
            980                 985                 990         


Arg Asn Lys Val Lys Lys Glu Ile  Asp Ser Leu Val Ala  Arg Met Thr 
        995                 1000                 1005             


Asn Arg  Asp Arg Gly Asn Cys  Lys Thr Leu Glu Glu  Ala Lys Lys 
    1010                 1015                 1020             


Lys Lys  Glu Asp Ile Leu Val  Asp Ala Ile Asn Gln  Val Lys Lys 
    1025                 1030                 1035             


Asn Glu  Lys Thr Ile Arg Arg  Phe Lys Thr Gln Asp  Ile Ile Leu 
    1040                 1045                 1050             


Phe Leu  Ile Ala Lys Gln Val  Leu Ile Gln Thr Asp  Glu Thr Ile 
    1055                 1060                 1065             


Lys Asn  Asn Ala Gln Ser Gln  Ser Glu Lys Phe Val  Ala Asp Glu 
    1070                 1075                 1080             


Ser Lys  Thr Ile Cys Leu Gly  Ser Thr Asn Pro Ile  Ser Tyr Glu 
    1085                 1090                 1095             


Gln Lys  Glu Asp Leu Glu Ser  Lys His Arg Ser Gly  Leu Ala Arg 
    1100                 1105                 1110             


Met Arg  Leu Ala Asp Val Phe  Glu Gly Asp Ser Leu  Asn Ile Pro 
    1115                 1120                 1125             


Leu Asp  Gln Thr Tyr Tyr His  Thr Ile Ser Trp Ile  Leu Lys Asp 
    1130                 1135                 1140             


Ser Asp  Gly Asn Glu Val Lys  Asp Ala Lys Gly Ser  Arg Ile Lys 
    1145                 1150                 1155             


Val Val  Arg Thr Val Arg Ile  Thr Gln Glu Asp Met  Ser Ile Lys 
    1160                 1165                 1170             


Asn Tyr  Gly Arg Ile Phe Gln  Ile Leu Ser Asp Lys  Arg Leu Asp 
    1175                 1180                 1185             


Asp Leu  Leu Lys Met Leu Ile  Gln Tyr Val Glu Ser  Asn Ala Pro 
    1190                 1195                 1200             


Ile Asn  Gly Asn Ser Tyr Ser  Ile Ala Tyr Asn Asp  Val Thr Ser 
    1205                 1210                 1215             


Glu Phe  Ala Asn Phe Asp His  Leu Arg Pro Glu Val  Phe Lys Glu 
    1220                 1225                 1230             


Ile His  Arg Leu Glu Ser Glu  Ala Phe Pro Lys Leu  Glu Asp Lys 
    1235                 1240                 1245             


Gln Ser  Glu Leu Thr Tyr Ser  Phe Asn Gly Leu Met  Gly Leu Leu 
    1250                 1255                 1260             


Phe Gln  Glu Asn Ala Ala Lys  Ser Ile Ile Asn Ile  Arg Asn Ala 
    1265                 1270                 1275             


Phe Val  His Gly Ser Tyr Arg  Val Asn Asn Ile Ile  Trp Glu Gly 
    1280                 1285                 1290             


Pro Asp  Ser Gln Ser Ala Glu  Leu Val Ala Pro Asn  Val Ser Arg 
    1295                 1300                 1305             


Lys Met  Lys Asp Arg Ile Ser  Pro Lys Asp Ser Lys  Glu Thr Lys 
    1310                 1315                 1320             


Tyr 
    


<210>  1712
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1712

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Thr 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1713
<211>  1199
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1713

Met Asn Thr Phe Ile Asp Ser Phe Ile Arg Arg Val Gln Ile Gln Asn 
1               5                   10                  15      


Gln Asn Gln Ser Trp Pro Lys Arg Pro Lys Tyr Val Arg Pro Val Glu 
            20                  25                  30          


Asn Ile Arg Pro Asp Asp Leu Ala Phe Gln Ser His Phe Thr Ala Tyr 
        35                  40                  45              


Leu Asn Met Ala Arg Gln Asn Cys Cys Ile Ile Leu Gly His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Gly Phe Lys Ala Ser Ser Val Lys Asp Thr Thr Leu Thr 
65                  70                  75                  80  


Ser Ser Pro Leu Leu Gly Gln Asn Gly Leu Leu Ser Pro Lys Lys Glu 
                85                  90                  95      


Val Ser Asp Leu Ile Arg Gly Arg Leu Leu Ser Ala Phe Pro Met Leu 
            100                 105                 110         


Asp Pro Met Ile Arg Tyr Arg Lys Ala Val Asp Lys Glu Lys Asp Asp 
        115                 120                 125             


Tyr Ala Arg Ile Ile Ile Thr Ser Glu Asp Val Ser Glu Met Leu Arg 
    130                 135                 140                 


Asp Leu Leu Asp Val Leu Ser Tyr Tyr Arg Asp Met Ala Ser His Val 
145                 150                 155                 160 


Val Phe Asn Asp Asp Arg Ser Val Ser Ala Glu Phe Ala Ser Lys Glu 
                165                 170                 175     


Lys Lys Val Ala Glu Cys Leu Asn Tyr Met Met Thr Val Ser Leu Arg 
            180                 185                 190         


Ile Val Lys Asp Arg Phe Ser Leu Ala Val Ser Asp Leu Asp Phe Tyr 
        195                 200                 205             


Asn Arg Asn Arg Tyr Met Met Val Asn Arg Lys Pro Leu Leu Asn Ala 
    210                 215                 220                 


Gly Phe Ala His Ala Val Arg Thr Glu Asp Tyr Arg Leu Thr Leu Met 
225                 230                 235                 240 


Gly Leu Val Leu Leu Cys Cys Gln Phe Ile Glu Lys Gln Tyr Ala Ser 
                245                 250                 255     


Met Phe Phe Asp Ala Leu Asp Lys His Ser Asn Gly Ala Arg Phe Tyr 
            260                 265                 270         


Gly Ile Ala Asp Ala Met Pro Met Val Asn Val Gly Thr Lys Asp Lys 
        275                 280                 285             


Pro Lys Lys Ile Pro Met Tyr Thr Gly Asp Glu Ala Gln Lys Gln Val 
    290                 295                 300                 


Gln Lys Gln Arg Met Ala Leu Arg Glu Ala Tyr Ser Val Tyr Arg Val 
305                 310                 315                 320 


Arg Ile Pro Lys Glu Arg Leu Glu Ser Thr Arg Ser Asp Met Ala Leu 
                325                 330                 335     


Ala Leu Asp Ile Leu Asn Glu Leu Gly Lys Cys Pro Glu Glu Leu Phe 
            340                 345                 350         


Glu His Leu Ser Pro Glu Asp Arg Glu Ser Phe Lys Asn Glu Glu Gly 
        355                 360                 365             


Val Leu Met Lys Arg Tyr Ser Asp Arg Phe Pro Gln Leu Ala Leu Arg 
    370                 375                 380                 


Trp Leu Asp Glu Asn Glu Lys Phe Asn Asn Leu Arg Phe His Val Thr 
385                 390                 395                 400 


Phe Gly Lys Tyr Arg Trp Leu Phe Cys Gln Asp Lys Lys Cys Ala Asp 
                405                 410                 415     


Gly Ser Val Arg Pro Arg Trp Leu Gln Lys Glu Leu Asn Gly Phe Gly 
            420                 425                 430         


Arg Ile Gln Thr Val Glu Arg Lys Arg Thr Gly Leu Glu Pro Gly Trp 
        435                 440                 445             


Asp Gly Thr Gly Leu Ile Arg Lys Phe Glu Glu Val Val Thr Asp Glu 
    450                 455                 460                 


Val Gln Lys Glu Pro Tyr Ile Thr Asp Phe Arg Thr Gln Tyr Leu Phe 
465                 470                 475                 480 


Asn Arg Asp Lys Ile Gly Ile Ser Leu Ser Glu Tyr Met Pro Gly Ile 
                485                 490                 495     


Gly Asp Ile His Ser Gly Lys Glu Trp Gly Lys His Ala Gly Val Pro 
            500                 505                 510         


Asp Phe Tyr Leu Ser Val Tyr Asp Ile Pro Ala Met Leu Phe Leu Thr 
        515                 520                 525             


Trp Leu Leu Gly Lys Asn Ser Ser Ala Val Glu Lys Leu Leu Ala Asn 
    530                 535                 540                 


Cys Lys Ala Ala Tyr Met Lys Leu Phe Asp Asp Leu Ala Lys Gly Lys 
545                 550                 555                 560 


Trp Glu Gly Glu Arg Asn Val Ser Asp Tyr Cys Ala Gly Glu Gly Thr 
                565                 570                 575     


Val Arg Tyr Thr Leu Arg Trp Tyr Asp Val Pro Met Lys Ile Arg Arg 
            580                 585                 590         


Lys Met Pro Leu Leu Gly Gly Asp Arg Asp Phe Glu Glu Lys Lys Ser 
        595                 600                 605             


Phe Glu Thr Leu Ala Gln Glu Ala Leu Thr Arg Met Leu Gln Arg Thr 
    610                 615                 620                 


Glu Asn Gln Leu Glu Lys Phe Asp Arg Asp Leu Ala Ala Ala Arg Asp 
625                 630                 635                 640 


Leu Lys Ala Asn Lys Gln Gly Lys Asp Arg Phe Val Asp Ile Arg Ala 
                645                 650                 655     


Gly Ser Leu Ala Thr Phe Leu Ala Arg Asp Ile Val Arg Leu Met Pro 
            660                 665                 670         


Val Ser Asp Asn Gly Arg Asn Lys Pro Thr Gly Leu Asn Tyr Ser Ile 
        675                 680                 685             


Val Gln Lys Ala Ile Ala Thr Tyr Lys Pro Ser Glu Gly Gly Leu Asp 
    690                 695                 700                 


Thr Leu Thr Gly Val Phe Arg Asp Ala Arg Ile Ile Gly Val Lys Gly 
705                 710                 715                 720 


Gly Ser His Pro Phe Leu Glu Arg Leu Leu Val Glu Lys Lys Pro Ser 
                725                 730                 735     


Ser Val Leu Ala Leu Tyr Arg His Tyr Leu Glu Tyr Arg Lys Glu Tyr 
            740                 745                 750         


Leu Lys Lys Ala Leu Glu Asp Glu Asn Lys Ala Glu Leu Lys Asn Leu 
        755                 760                 765             


Pro Phe Leu Lys Ser Gly Arg Gln Lys Tyr Ala Val Asp Gln Ala Asp 
    770                 775                 780                 


Tyr Ala Arg Arg Leu Ala Glu Ser Tyr Arg Asn Cys Pro Ile Tyr Leu 
785                 790                 795                 800 


Pro Thr Gly Ile Phe Thr Asp Met Leu Lys Asp Gln Leu Ala Lys Ile 
                805                 810                 815     


Asp Val Met Lys Pro Val Leu Glu Asn Asp Lys Val Asn Ala Ser Tyr 
            820                 825                 830         


Leu Ile Ala Gln Tyr Phe Glu Lys Val Glu His Asp Ser Glu Gln Pro 
        835                 840                 845             


Leu Tyr Arg Leu Lys Arg Asn Tyr Arg Val Phe Asp Leu Leu Glu Phe 
    850                 855                 860                 


Thr Asp Glu Pro Lys Tyr Trp Arg Leu Asn Glu Arg Ser Asp Lys Ala 
865                 870                 875                 880 


Gly Lys Tyr Gly Leu Ala Lys Arg Asn Ile Phe Trp Asn Arg Met Gly 
                885                 890                 895     


Glu Tyr Tyr Lys Gly Leu Lys Lys Phe Tyr Lys Gly Tyr Glu Ser Lys 
            900                 905                 910         


Arg Thr Ala Val Asp Trp Arg Glu Lys Leu Lys Ile Val Glu Ala Glu 
        915                 920                 925             


His Ala Met Trp Asn Arg Leu Lys Asp Ala Ser Gly Glu Ala Arg Leu 
    930                 935                 940                 


Lys Met Lys Asp Gly Val Phe Tyr Ser Arg Leu Leu Ser Ala Arg Lys 
945                 950                 955                 960 


Glu Tyr Asp Asp Cys Glu Arg Ala Leu Arg Arg Leu Lys Val Gln Asp 
                965                 970                 975     


Ile Val Leu Phe Leu Ala Ala Arg Glu Thr Leu Ile Leu Pro Lys Asp 
            980                 985                 990         


Lys Val Phe Arg Leu Lys Asn Leu  Ser Leu Ser Glu Gly  Asn Lys Asn 
        995                 1000                 1005             


Ile Leu  Ser Ser Ala Ile Asp  Glu Phe Ser Val Asp  Val Val Trp 
    1010                 1015                 1020             


Thr Glu  Lys Glu Gly Ala Ala  Lys Val Thr His Ser  Ala Ser Ile 
    1025                 1030                 1035             


Lys Glu  Asn Asp Val Val Ile  Lys Asn Tyr Gly Arg  Met Phe Arg 
    1040                 1045                 1050             


Leu Leu  His Asp Asp Arg Val  Lys Thr Leu Leu Pro  His Ile Tyr 
    1055                 1060                 1065             


Asp Ser  Ala Leu Ser Glu Asn  Ile Thr Gly Asp Arg  Ile Thr Val 
    1070                 1075                 1080             


Lys Asp  Asn Lys Val Ile Ile  Asp Lys Ser Leu Phe  Asp Glu Asp 
    1085                 1090                 1095             


Leu Met  Asn Tyr Asp Leu Arg  Arg His Glu Ile Cys  Glu Ile Ile 
    1100                 1105                 1110             


Leu Arg  Phe Glu Ala Ala Ser  Ile Lys Arg Phe Gly  Leu Asp Gly 
    1115                 1120                 1125             


Arg Val  Asp Phe Lys Ala Ala  Leu Asp Ala Leu Thr  Gly Arg Ser 
    1130                 1135                 1140             


Leu Leu  Asn Asp Glu Asp Ala  Arg Ile Leu Ser Ala  Ile Arg Asn 
    1145                 1150                 1155             


Ala Tyr  Asn His Asn Lys Tyr  Pro Ala Lys Gly Thr  Asp Val Lys 
    1160                 1165                 1170             


Val Asn  Val Met Ala Leu Pro  Lys Leu Thr Glu Asp  Leu Leu Arg 
    1175                 1180                 1185             


Ile Phe  Ser Asp Thr Gly Asn  Asn Arg Val Arg 
    1190                 1195                 


<210>  1714
<211>  1048
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1714

Met Cys Cys His Thr Gly Ser Gly Asn Asp Tyr Leu Glu Ala Phe Phe 
1               5                   10                  15      


Leu Arg Thr Phe Cys Ile Glu Lys Glu Leu Ser Leu Ser Lys Gln Arg 
            20                  25                  30          


Thr Ile Leu Ile Asp Met Ala Cys Ile Ile Gly Arg Tyr Arg Asn Met 
        35                  40                  45              


Tyr Ser His Ser Ile Phe Leu Ser Asp Asp Asn Glu Lys Val Leu Glu 
    50                  55                  60                  


Ser Glu Lys Arg Cys Ser Glu Tyr Leu Gln Ser Ile Leu Thr Val Ser 
65                  70                  75                  80  


Thr Arg Ile Ile Lys Glu Arg Tyr Arg Ser Asn Lys Asn Asp Ala Gln 
                85                  90                  95      


Arg Gly Met Ile Asp Asp Lys Ser Leu Glu Phe Ile Ser Glu Asn Lys 
            100                 105                 110         


Val Lys Phe Val Tyr Asp Glu Asn Gly Lys Arg Ile Thr Ala Pro Asn 
        115                 120                 125             


Lys Lys Tyr Tyr Leu Ser Thr Ile Asp Lys Asp Asn Thr His Leu Ser 
    130                 135                 140                 


Tyr Phe Gly Lys Leu Met Leu Thr Cys Ile Leu Leu Glu Lys Lys Tyr 
145                 150                 155                 160 


Ala Thr Ala Phe Leu Thr Gln Cys His Phe Leu Asp Ala Phe Asn Asp 
                165                 170                 175     


Ser Glu Ala Ala Pro Lys Leu Ser Glu Arg Arg Leu Met Leu Glu Val 
            180                 185                 190         


Met Thr Ala Leu Arg Ile Arg Leu Ala Glu Lys Lys Leu Ser Asn Glu 
        195                 200                 205             


Lys Ser Glu Val Gln Ile Ser Leu Asp Ile Leu Asn Glu Leu Lys Lys 
    210                 215                 220                 


Cys Pro Phe Glu Leu Tyr Glu Leu Leu Gly Ser Glu Asp Lys Arg Leu 
225                 230                 235                 240 


Phe Thr Ile Val Ala Asp Thr Gly Glu Thr Ile Leu Leu Arg Arg His 
                245                 250                 255     


Glu Asp Arg Phe Pro Gln Leu Ala Leu Ser Trp Ile Asp Ser Ser Lys 
            260                 265                 270         


Ala Phe Asp His Leu Arg Phe Gln Val Asn Ala Gly Lys Leu Arg Tyr 
        275                 280                 285             


Leu Phe Arg Asp Asn Lys His Cys Ile Asp Gly Gln Thr Arg Met Arg 
    290                 295                 300                 


Val Leu Glu Glu Pro Leu Asn Gly Tyr Arg Arg Leu Met Glu Phe Glu 
305                 310                 315                 320 


Glu Glu Arg Ile Gln Lys Gln Ser Gly Glu Ile Arg Ser Leu Trp Pro 
                325                 330                 335     


Gly Leu Asp Ile Leu Asn Lys Asp Glu Thr Pro Arg Asn Asp Ala Ser 
            340                 345                 350         


Val Leu Pro Tyr Ile Ser Asp Tyr Arg Val Arg Tyr Leu Phe Asp Gly 
        355                 360                 365             


Asp Asn Ile Gly Ile Ser Ile Gly Asp Phe Thr Pro Ser Ile Thr Lys 
    370                 375                 380                 


Thr Asp Glu Thr Lys Tyr Arg Val Thr Gly Lys Thr Ala Asp Cys Cys 
385                 390                 395                 400 


Leu Ser Lys Tyr Glu Leu Pro Gly Leu Leu Phe Tyr His Leu Leu Thr 
                405                 410                 415     


Leu Arg Tyr Gly Asp Asn Lys Arg Ser Thr Lys Asn Ala Glu Asp Ile 
            420                 425                 430         


Ile Ile Asp Ala Ile Lys Arg Tyr Lys Arg Leu Phe Ser Asp Val Lys 
        435                 440                 445             


Glu Gly Ile Leu Lys Pro Ile Lys Glu Gly Asn Ala Asn Gln Leu Gly 
    450                 455                 460                 


Asn Arg Ile Trp Asn Ser Tyr Gly Ile Asp Ile Lys Asp Ile Pro Asp 
465                 470                 475                 480 


Lys Ile Ile Asp Tyr Leu Leu Val Arg Glu Cys Asn Glu Asp Glu Lys 
                485                 490                 495     


Phe Thr Ala Trp Lys Asn Gly Leu Ile Ser Glu Met Leu Gln Ser Thr 
            500                 505                 510         


Lys Asn Arg Ile Lys Arg Phe Glu Lys Asp Ser Glu Ala Val Ile Ser 
        515                 520                 525             


Ser Asp Asn Lys Pro Gly Lys Lys Asn His Val Ser Leu Lys Pro Gly 
    530                 535                 540                 


Ala Tyr Ala Ser Phe Ile Ala Asn Asp Ile Val Phe Phe Gln Glu Cys 
545                 550                 555                 560 


Gly Ala Thr Glu Lys Met Thr Gly Leu Asn Phe Lys Val Met Gln Ser 
                565                 570                 575     


Arg Leu Ala Thr Phe Thr Lys Asp Gly Ser Thr Ser Phe Asn Ile Leu 
            580                 585                 590         


Leu Gln Thr Leu Lys Asn Ala His Leu Val Ser Asn Thr Tyr Gly Lys 
        595                 600                 605             


Gly Asp His Pro Phe Leu Tyr Arg Val Ile Lys Gln Gln Pro Ser Asp 
    610                 615                 620                 


Ile Val Gln Phe Tyr Lys Ile Tyr Leu Asn Glu Lys Val Leu Tyr Leu 
625                 630                 635                 640 


Gln Ser Asp Ile Pro Asp Asn Ala Ile Phe Leu His Gly Glu Arg Lys 
                645                 650                 655     


Arg Trp Glu Asn Arg Asn Glu Gln Tyr Tyr Arg Asp Leu Ala Glu Arg 
            660                 665                 670         


Tyr Leu Gln Arg Pro Ile Gln Leu Pro Arg Gln Leu Phe Glu Ser His 
        675                 680                 685             


Ile Arg Gln Leu Leu Leu Ser Asp Cys Ile Lys Gly Glu Arg Gly Asn 
    690                 695                 700                 


Asp Leu Lys Glu Ala Ile Asn Ser Ala Ala Ser Gln Gly Arg Cys Asn 
705                 710                 715                 720 


Thr Thr Tyr Met Ile Met Glu Tyr Phe Ala Asp Tyr Leu Cys Asp Gly 
                725                 730                 735     


Thr Gln Phe Phe Tyr Gly Leu Phe Asp Gly Asp Leu Ser His Glu Tyr 
            740                 745                 750         


Asn Tyr Arg Phe Tyr Ser Leu Ile Ser Asn Asn Ile Glu Asn Ser Lys 
        755                 760                 765             


Lys Leu Val Leu Thr Leu Lys Lys Gly Asn Asn Ser Lys Glu Ser Pro 
    770                 775                 780                 


Phe Ile Ser Ala Leu Glu Arg Gly Ile His Trp Ser Lys Arg Asn Pro 
785                 790                 795                 800 


Leu Met Lys Lys Gly Leu Lys Asn Asp Ser Ser Glu Gly Asp Phe Val 
                805                 810                 815     


His Ala Ala Lys Arg Ala Tyr Lys Glu Met Thr Glu Thr Glu Arg Met 
            820                 825                 830         


Phe Arg Arg Tyr Ala Val Gln Asp Glu Val Leu Phe Leu Ala Ala Lys 
        835                 840                 845             


Ile Thr Ile Arg Arg Ala Leu Gly Leu Ser Glu Gln Tyr Asn Cys Leu 
    850                 855                 860                 


Leu Gly Asp Ile Lys Pro Gln Gly Gly Ser Leu Leu Glu Gln Thr Ile 
865                 870                 875                 880 


Pro Ser Ile Thr Thr Lys His Thr Ile Asn Thr Gly Asn Lys Lys Gln 
                885                 890                 895     


Lys Pro Lys Gln Val Gln Ile Leu Gln Lys Asn Val Lys Leu Lys Asp 
            900                 905                 910         


Phe Gly Lys Val Phe Lys Leu Leu Asn Asp Arg Arg Ile Phe Asp Leu 
        915                 920                 925             


Leu Phe Asn Lys Gly Asn Glu Ala Val Ser Met Thr Asp Leu Cys Glu 
    930                 935                 940                 


Glu Leu Glu Arg Tyr Asp Arg His Arg Val Asp Val Phe Asp Ser Val 
945                 950                 955                 960 


Leu Lys Tyr Glu Ser Lys Ile Thr Lys Gly Tyr Thr Asn Lys Glu Leu 
                965                 970                 975     


Met Asn Glu Ser Gly Gln Ile Asp Phe Lys Ala Ile Gln Ala Phe Asp 
            980                 985                 990         


Lys Gln Asn Thr Thr Ala Asp Lys  Glu Asp Leu Arg Leu  Ile Arg Asn 
        995                 1000                 1005             


Ala Phe  Ser His Asn Gln Tyr  Pro Gln Tyr Asn Asn  Glu Pro Ile 
    1010                 1015                 1020             


Leu Phe  Asp Lys Asp Ile Pro  Glu Ile Ala Asp Glu  Ile Ser Ile 
    1025                 1030                 1035             


Ile Ala  Lys Asp Ile Glu Glu  Asn Thr Lys 
    1040                 1045             


<210>  1715
<211>  1171
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1715

Met Ala Leu Lys Gln Trp Arg Gln Ser Lys Thr Pro Asn Leu Lys Pro 
1               5                   10                  15      


Val Phe Ser Ala Tyr Leu Asn Met Ala Arg His Asn Cys Tyr Lys Ser 
            20                  25                  30          


Leu Leu His Val Ser Lys Leu Met Gln Ile Ser Glu Ser Asn Glu Glu 
        35                  40                  45              


Glu Asn Ile Thr Met Phe Ser Leu Trp Asp Lys Leu Val Lys Gly Thr 
    50                  55                  60                  


Pro Thr Glu Lys Leu Lys Ile Ile Gln Leu Leu Gln Lys His Phe Pro 
65                  70                  75                  80  


Met Met Gln Gly Ile Phe Asp Ile Glu Lys Arg Thr Asn Ile Ser Ile 
                85                  90                  95      


Ala Thr Asn Pro Lys Glu Ile Lys Arg Thr Leu His Ala Phe Phe His 
            100                 105                 110         


Val Leu Asn Ser Leu Arg Asn Glu Tyr Thr His Phe Ser Pro Asp Pro 
        115                 120                 125             


Arg Asn Thr Thr Asn Asp Ala Val Ile Ile Pro Tyr Leu Tyr Arg Cys 
    130                 135                 140                 


Met Asp Gly Ala Ala Arg Glu Ile Lys Lys Arg Phe Ser Leu Thr Ile 
145                 150                 155                 160 


Lys Lys Ala Ile Ser Leu Asn Asn Glu Glu Ser Ser Gln Ile His Asp 
                165                 170                 175     


Val Asn Lys Ala Val Glu Tyr Ile Phe Gln Cys Asp Phe Arg Lys Ala 
            180                 185                 190         


Lys Val Asn Asp Leu Asp Lys Asn Gly Lys Val Leu Tyr Gln Lys Asn 
        195                 200                 205             


Gly Lys Ile Lys Thr Lys Met Val Asp Lys Glu Asp Tyr Phe Tyr Ser 
    210                 215                 220                 


Leu Lys Glu Ser Ser Glu Thr Val Gln Asp Asp Ala Ser Lys Lys Gly 
225                 230                 235                 240 


Asn Leu Arg Lys Lys Ile Val Leu Ser Asp Ile Gly Ile Ile Phe Phe 
                245                 250                 255     


Thr Cys Leu Phe Leu Glu Lys Arg Tyr Ile Lys Asn Phe Leu Asp Ala 
            260                 265                 270         


Ile Lys Pro Trp Pro Asn Val Phe Asn Glu Ile Gln Lys Lys Ala Val 
        275                 280                 285             


Phe Glu Val Phe Ser Val Phe His Ile His Leu His Arg Glu Lys Tyr 
    290                 295                 300                 


Asp Ser Cys Arg Pro Glu Tyr Ala Leu Gly Leu Asp Met Leu Asn Glu 
305                 310                 315                 320 


Leu Gln Lys Cys Pro Ala Glu Leu Phe Asp Ile Leu Ser Asp Lys Asp 
                325                 330                 335     


Arg Asp Arg Leu Ser Val Asp Ile His Ala Gln Gly Asp Asn Ile Val 
            340                 345                 350         


Gln Asn Asp Gly Val Thr Val Lys Ser Gly Lys Val Leu Met Lys Arg 
        355                 360                 365             


Met Arg Asp Arg Phe Ala Pro Phe Ala Leu Gln Tyr Ile Asp Arg Gln 
    370                 375                 380                 


Asn Ile Phe Lys Asp Ile Arg Phe Met Val His Leu Gly Asn Tyr Arg 
385                 390                 395                 400 


Phe Lys Phe Tyr Lys Lys Arg Cys Leu Ala Asp Asp Gly Glu Asp Thr 
                405                 410                 415     


Leu Arg Thr Leu Gln Lys Glu Ile Asn Gly Phe Gly Arg Ile Gln Glu 
            420                 425                 430         


Ile Glu Met Glu Arg Lys Lys Asn Tyr Ser Ser Phe Phe Lys Glu Ala 
        435                 440                 445             


Thr Thr Lys Val Asn Glu Tyr Asn Lys Asn Val Gln Glu Leu Lys Ala 
    450                 455                 460                 


Asp Thr Thr Asp Ser Ala Pro Tyr Met Thr Asn Ser Thr Ala His Tyr 
465                 470                 475                 480 


Leu Phe Asp Gly Asn Arg Val Gly Leu Arg Leu Phe Asn Ser Glu Ser 
                485                 490                 495     


Asp Met Lys Ser Phe Val Pro Asn Val Lys Ile Gln Gly Arg Pro Ala 
            500                 505                 510         


Thr Lys Ala Ser Glu Ile Lys Leu Leu Ser Pro Asp Ala Trp Ile Ser 
        515                 520                 525             


Thr Tyr Glu Leu Pro Gly Met Ile Phe Tyr Leu Arg Leu Tyr Lys Glu 
    530                 535                 540                 


Tyr Met Gly Lys Thr Asn Gly Tyr Pro Ser Ala Glu Asp Ile Leu Lys 
545                 550                 555                 560 


Ser Tyr Ile Asp Ala Tyr His Arg Ile Phe Asp Asp Ile Lys Asn Gly 
                565                 570                 575     


Thr Phe Lys Gly Trp Asp Asp Ile Leu Tyr Gln Pro Leu Thr Lys Lys 
            580                 585                 590         


Asp Leu Pro Ile Lys Ile Lys Arg Tyr Ile Asp Gln Pro Asn Ser Thr 
        595                 600                 605             


Gln Ser Ala Tyr Phe His Lys Lys Ser Arg Thr Arg Ile Lys Ile Met 
    610                 615                 620                 


Tyr Tyr Trp Thr Leu Arg Glu Leu Lys Cys Phe Asp Thr Lys Leu Glu 
625                 630                 635                 640 


Lys Met Lys Ser Lys Asp Asn Lys Phe Lys Lys Lys Asp Tyr Val Asp 
                645                 650                 655     


Leu Arg Pro Gly Asp Ile Ala Lys Trp Leu Thr Arg Asp Ile Leu Tyr 
            660                 665                 670         


Phe Met Glu Asp Phe Asp Glu Lys Gly Thr Ile Thr Ser Ala Asn Phe 
        675                 680                 685             


Asn Ser Leu Arg Ser Ala Leu Thr Leu Ser Asp Thr Ser Lys Glu Lys 
    690                 695                 700                 


Val Tyr Gly Met Ile Ser Ser Phe Lys His Pro Phe Leu Ala Lys Ala 
705                 710                 715                 720 


Leu Glu Thr Tyr Asp Lys Glu His Asn Glu Glu Cys Phe Arg Ile Phe 
                725                 730                 735     


Asp Phe Tyr Arg Ala Tyr Leu Thr Lys Arg Ala Asp Tyr Leu Lys Gln 
            740                 745                 750         


Ile Gln Lys Ile Lys Gly Asn Glu Leu Leu Lys Leu Ala Phe Leu His 
        755                 760                 765             


Ser Thr Arg Lys Arg Trp Lys Asp Arg Gly Ile Thr Ala Ile Lys Asp 
    770                 775                 780                 


Leu Ala Met Thr Tyr Glu Gln Phe Glu Leu Pro Arg Gly Ile Phe Thr 
785                 790                 795                 800 


Pro Leu Ala Lys Lys Ile Leu Val Glu Lys Cys Gly Leu Ser Leu Asp 
                805                 810                 815     


Thr Glu Thr Glu Lys Lys Lys Leu Gly Met Ala Asn Leu Ile Asn Phe 
            820                 825                 830         


Tyr Phe Glu Ser Val Leu Lys Asp Lys Asn Gln Asp Phe Tyr Arg Trp 
        835                 840                 845             


Ser Arg His Tyr Lys Ile Phe Asp Leu Leu Glu Thr Asn Thr Ser Lys 
    850                 855                 860                 


Asn Ser Gln Ala His Asn Phe Leu Leu Pro Glu Gln Leu Thr Thr Lys 
865                 870                 875                 880 


Met Arg Lys Asn Lys Glu Phe Glu Ile Asn Asn Leu Ile Arg Asn Lys 
                885                 890                 895     


Ala Lys Lys Ala Ile Glu Ala Glu Ile Lys Tyr Lys Lys Asn Asn Pro 
            900                 905                 910         


Thr Tyr Ile Asp Tyr Phe Asn Glu Asn Phe Lys Ser Thr Thr Glu Val 
        915                 920                 925             


Ala Lys Asn Ile Leu His Asn Ala Tyr Lys Asn Tyr Asp Asp Asn Glu 
    930                 935                 940                 


Arg Ile Leu Arg Arg Tyr Ala Ile Gln Asp Arg Leu Met Phe Leu Met 
945                 950                 955                 960 


Ala Lys Asp Leu Leu Leu Gly Ile Glu Gly Ile Gly Lys Gly Ala Leu 
                965                 970                 975     


Arg Ser Phe Arg Leu Gly Asp Ile Met Pro Asn Lys Asp Lys Thr Ile 
            980                 985                 990         


Leu Asp Leu Leu Val Pro Phe Thr  Val Thr Leu Asn Ile  Asp Gly Ile 
        995                 1000                 1005             


Ser Val  Ser Ile Arg Gln Lys  Asp Ala Ile Lys Ile  Lys Arg Tyr 
    1010                 1015                 1020             


Gly Glu  Phe Tyr Arg Tyr Asn  Ser Asp Thr Arg Leu  Lys Ser Leu 
    1025                 1030                 1035             


Leu Pro  Tyr Leu Ile His Lys  Val Gly Asn Lys Ala  Glu Ile Asn 
    1040                 1045                 1050             


Ile Asp  Ile Asp Arg Glu Glu  Leu Glu Ala Glu Leu  Asn Gln Tyr 
    1055                 1060                 1065             


Asp His  Glu Arg Ile Glu Ile  Met Arg Lys Val Gln  Ser Leu Glu 
    1070                 1075                 1080             


Arg Ser  Ile Ile Ala Lys Val  Gly Gly Glu Lys Asn  Val Glu Lys 
    1085                 1090                 1095             


Glu Ile  Arg Glu Asn Phe Asn  Asn Leu Ile Thr Gln  Lys Gly Asn 
    1100                 1105                 1110             


Ile Pro  Tyr Glu Arg Gln Gly  Lys Ile Leu Val Asn  Ile Arg Asn 
    1115                 1120                 1125             


Ser Phe  Cys His Asn Glu Tyr  Ala Lys Asp Ile Asp  Phe Pro Glu 
    1130                 1135                 1140             


Asn Ile  Pro Leu Pro Gln Ile  Ala Asp Thr Ile Val  Ser Leu Phe 
    1145                 1150                 1155             


Glu Ala  Glu Arg Lys Asn Arg  Pro Lys Gly Glu Thr  Met 
    1160                 1165                 1170     


<210>  1716
<211>  1347
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (683)..(689)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1077)..(1077)
<223>  Xaa can be any naturally occurring amino acid

<400>  1716

Met Pro Lys Asn Lys Lys Gln Ala Gln Asn Ser Phe Pro Lys Gly Asn 
1               5                   10                  15      


Asn Ser Ala Pro Asn Gln Asn Lys Asn Lys His Thr Ser Ser Asn Gln 
            20                  25                  30          


Gly Lys Ser Gln Gly Asn Asn Thr Pro Lys Pro Asn Gln Lys Ala Val 
        35                  40                  45              


Lys Glu Pro Lys Pro Leu Lys Val Thr Lys Asp Asn Lys Tyr Val Leu 
    50                  55                  60                  


Gly Gly Tyr Phe Gly Leu Gly Leu Asn Asn Phe Phe Lys Ala Ile Leu 
65                  70                  75                  80  


Ser Val Phe Ala Lys Thr Gly Ile Lys Val Ala Ser Ser Lys Gly Thr 
                85                  90                  95      


Val Leu Tyr Pro Glu Glu Lys Ile Gly Ala Val Leu Arg Thr Leu Tyr 
            100                 105                 110         


Tyr Met Val Ala Ala Ser Asp His Lys Phe Thr Pro Glu Glu Gln Thr 
        115                 120                 125             


Trp Ser Lys Asn Phe Asn Leu Asn Val Thr Gln Gln Glu Arg Leu Lys 
    130                 135                 140                 


Lys Leu Leu Phe His His Phe Pro Ile Leu Gly Pro Ile Met Ala Gly 
145                 150                 155                 160 


Glu Thr Ser Tyr Lys Ala Tyr Asn Asn Lys Lys Ser His Val Ser Asp 
                165                 170                 175     


Ala Tyr Ser Leu Thr Tyr Gly Val Thr Leu Ala Glu Cys Leu Asp Ala 
            180                 185                 190         


Leu Ser Thr Leu Ala Gln Gly Leu Ala Asp Cys Arg Asn Ser Tyr Thr 
        195                 200                 205             


His Tyr Asp Pro His Asn Thr Asn Glu Ser Leu Lys Glu Gln Tyr Glu 
    210                 215                 220                 


Val Gln Ser Lys Ile Val Arg Tyr Leu Asp Lys Val Met Val Ala Ser 
225                 230                 235                 240 


Arg Arg Ile Asp Lys Glu Arg Asn Asn Ile Asp Thr Lys Gln Met Glu 
                245                 250                 255     


Phe Leu Thr Gly Cys Ala Asp Asn Leu Lys Ser Tyr Ile Asn Leu Tyr 
            260                 265                 270         


Gly Phe Tyr Pro Lys Tyr Asp Lys Thr Val Val Lys Asp Glu Lys Gly 
        275                 280                 285             


Arg Thr Val Lys Lys Met Val Glu Arg Asp Asp Phe Phe Tyr Lys Ile 
    290                 295                 300                 


Gly Glu Lys Met Asn Phe Gly Gly Glu Ser Phe Thr Val Leu Ser Gly 
305                 310                 315                 320 


Phe Gly Leu Thr Tyr Phe Cys Ala Ile Phe Leu Ser Lys Ser Gln Thr 
                325                 330                 335     


Lys Gln Met Leu Ala Asp Ile Lys Leu Phe Glu Ala Ser Pro Tyr Pro 
            340                 345                 350         


Pro Glu Leu Asn Glu Ile Val Arg Glu Ile Met Cys Ile Tyr Arg Ile 
        355                 360                 365             


Arg Ala Pro Arg Gly Lys Lys Lys Leu Glu Ser Gly Asp Ser Lys Ile 
    370                 375                 380                 


Thr Leu Ala Leu Asp Ile Leu Asn Glu Leu Arg Lys Cys Pro Lys Glu 
385                 390                 395                 400 


Leu Phe Asp Val Leu Thr His Thr Gly Gln Lys Phe Phe Glu Glu Asn 
                405                 410                 415     


Ile Gly Ser Gly Thr Glu Ser Ser Asp Glu Met Glu Asp Val Val Lys 
            420                 425                 430         


Arg Ile Arg His Thr Asp Arg Phe Ser His Leu Ala Met Lys Tyr Ile 
        435                 440                 445             


Asp Glu Thr Glu Leu Phe Arg Asn Ile Arg Phe Gln Val Gln Leu Gly 
    450                 455                 460                 


Lys Phe Arg Phe Lys Phe Tyr Asp Lys Lys Cys Ile Asn Gly Glu Val 
465                 470                 475                 480 


Asp Leu Arg Ser Leu Gln Lys Glu Ile Asn Gly Phe Gly Arg Ile Gln 
                485                 490                 495     


Glu Ile Glu Pro Lys Arg Lys Glu Lys Tyr Lys Asp Ile Leu Gln Arg 
            500                 505                 510         


Ala Gln Thr Asp Lys Val Lys Ile Glu Gly Gln Asp Leu Glu Leu Asp 
        515                 520                 525             


Leu Leu Gln Phe Glu Lys Asp Thr Lys Ala Ser Ala Pro Tyr Ile Thr 
    530                 535                 540                 


Asp Ser Arg Ala Phe Tyr Asn Ile His Asn Asn Arg Ile Gly Leu Tyr 
545                 550                 555                 560 


Trp Asn Glu Cys Leu Ala Asn Gly Met Thr Ile Pro Thr Pro Gly Asp 
                565                 570                 575     


Tyr Ile Pro Glu Leu Glu Val Thr Glu Asp Gly Lys Ala Lys Val Glu 
            580                 585                 590         


Met Pro Ala Pro Ile Ala Leu Met Ser Ile Tyr Glu Leu Pro Ala Leu 
        595                 600                 605             


Val Phe Tyr Gln Tyr Leu Leu Ser Ala His Glu Thr Asp Pro Arg Lys 
    610                 615                 620                 


Ser Lys Asn Asn Ser Ala Glu Arg Leu Ile Ile Glu Lys Cys Gln Ala 
625                 630                 635                 640 


Leu Arg Gln Phe Phe Ser Asp Val Ser Ser Gly Ser Leu Ala Pro Val 
                645                 650                 655     


Gly Lys Arg Ala Ile Leu Ser Ala Thr Leu Met Glu Arg Tyr Gly Leu 
            660                 665                 670         


Lys Leu Asn Glu Val Pro Asp Lys Leu Val Xaa Xaa Xaa Xaa Xaa Xaa 
        675                 680                 685             


Xaa Lys Ala Glu Val Ile Thr Gln Gln Leu Ile Arg Arg Leu Arg Ser 
    690                 695                 700                 


Ala Ile Arg Arg Arg Asp His Tyr Ile Glu Asp Arg Lys Lys Ile Gly 
705                 710                 715                 720 


Gly Lys Asp Asn Lys Tyr Ala Lys Lys Ala Tyr Val Asp Val Arg His 
                725                 730                 735     


Gly Ala Leu Gly Arg Tyr Leu Ser Glu Ser Leu Val Glu Trp Gln Pro 
            740                 745                 750         


Thr Lys Asn Gly Gly Lys Asp Lys Leu Thr Gly Met Asn Phe Asn Lys 
        755                 760                 765             


Leu Gln Ala Glu Leu Glu Thr Phe Ser Asn Pro Asp Lys Phe Asp Val 
    770                 775                 780                 


Ile Lys Met Ala Met Gln Gly Ala Gly Met Leu Ser Gly Asp Ile Ala 
785                 790                 795                 800 


His Pro Phe Leu Asn Arg Val Met Ser Arg Gln Ala Arg Asn Ile Glu 
                805                 810                 815     


Glu Leu Tyr Arg Phe Tyr Leu Asp Glu Glu Ile Lys Tyr Leu Lys Ser 
            820                 825                 830         


Phe Phe Asp Leu Ser Asp Lys Asn Thr Pro Lys Lys Asp Ser Asn Leu 
        835                 840                 845             


Asp Phe Asp Lys Leu Lys Leu Lys Gln Asn Val Asp Ile Ser Gly Ile 
    850                 855                 860                 


Pro Phe Val Arg Gly Asn Ala Arg Trp Glu Glu Arg Asn Glu Asp Tyr 
865                 870                 875                 880 


Tyr Arg Lys Leu Ala Lys Arg Tyr Leu Glu Val Asp Gly Leu Arg Thr 
                885                 890                 895     


Ser Ile Trp Leu Pro Asp Gly Ile Phe Thr Asn Ala Ile Val Gly Ile 
            900                 905                 910         


Leu Lys Glu Cys Ala Val Ala Asn Pro Ala Leu Ser Glu Arg Leu Ala 
        915                 920                 925             


Asn Glu Glu Leu Asn Asn Asn Val Ala Tyr Leu Ile Asn Thr Tyr Phe 
    930                 935                 940                 


Glu Thr Ile Leu Asn Asp His Ser Gln Val Phe Tyr Arg Ser Phe Asp 
945                 950                 955                 960 


Ile Asp Pro Ala Thr Gly Lys Glu Lys Pro Asn Lys Phe Ala Arg Val 
                965                 970                 975     


Tyr Asp Leu Phe Asn Ile Leu Asn Asn Val Lys Val Arg Asn Ala Leu 
            980                 985                 990         


Val Glu Val Pro Met Thr Cys Asn  Gly Ile Thr Ala Arg  Leu Thr Glu 
        995                 1000                 1005             


Lys Ala  Val Gly Tyr Gly Gly  Glu Pro Leu Val Val  Tyr Gly Pro 
    1010                 1015                 1020             


Lys Asn  Lys Pro Met Arg Ala  Pro Asn Gly Asp Arg  Val Tyr Met 
    1025                 1030                 1035             


Lys Gln  Ile Asn Val Glu Ile  Asn Asp Arg Val Ala  Ala Met Gly 
    1040                 1045                 1050             


Glu Arg  Asp Lys Gly Asn His  Ala Thr Leu Glu Asp  Ala Gln Glu 
    1055                 1060                 1065             


Ala Met  Arg Arg Arg Leu Leu  His Xaa His Cys Val  Ser Asp Val 
    1070                 1075                 1080             


Lys Asn  Asn Glu Arg Ala Ile  Arg Arg Tyr Lys Thr  Gln Asp Met 
    1085                 1090                 1095             


Val Leu  Phe Leu Ile Ala Ala  Gln Leu Leu Gly Asp  Ala Val Lys 
    1100                 1105                 1110             


Leu Asn  Lys Ile Asn Glu Ile  Asn Lys Phe Ser Leu  Lys Asn Val 
    1115                 1120                 1125             


Cys Ser  Lys Gly Phe Leu Ser  Gln Thr Ile Asn Phe  Glu Phe Pro 
    1130                 1135                 1140             


Ile Glu  Ile Asp Ser Lys Thr  Val Tyr Val Ser Gln  Asp Asn Met 
    1145                 1150                 1155             


Ser Leu  Lys Asn Tyr Gly Glu  Phe Tyr His Leu Leu  Asn Asp Asp 
    1160                 1165                 1170             


Arg Leu  Pro Ser Leu Leu Ser  Lys Leu Ala Ala Ala  Ala Gln Glu 
    1175                 1180                 1185             


Gly Glu  Lys Ser Val Val Asp  Tyr Asn Lys Leu Met  Gly Glu Leu 
    1190                 1195                 1200             


Thr Ser  Tyr Asp Leu His Arg  Ser His Ile Phe His  Ala Ile His 
    1205                 1210                 1215             


Gln Leu  Glu Lys Arg Ile Thr  Ser Asp Pro Gly Phe  Lys Pro Phe 
    1220                 1225                 1230             


Leu Arg  Asn Pro Ser Asp Val  Arg Phe Tyr Ile Asp  Asn Asp Lys 
    1235                 1240                 1245             


Thr Arg  Met Ala Lys Arg Asn  Asn Phe Arg Ser Leu  Leu Thr Leu 
    1250                 1255                 1260             


Leu Glu  Glu Gly Asp Thr Lys  Leu Leu Glu Lys Ser  Glu Arg Glu 
    1265                 1270                 1275             


Leu Ile  Ile Ser Ile Arg Asn  Ala Phe Ser His Asn  His Tyr Asn 
    1280                 1285                 1290             


Val Asp  Phe Asn Arg Ile Ala  Ser Arg Asn Ala Leu  Ser Arg Thr 
    1295                 1300                 1305             


Thr Leu  Met Asn Lys Pro Asp  Glu Asn Asp Lys Asp  Asn Arg Ala 
    1310                 1315                 1320             


Lys Leu  Thr Thr Ile Ala Thr  Leu Ile Ser Ala Arg  Leu Glu Glu 
    1325                 1330                 1335             


Leu Gln  Asn Ile Ile Asn Arg  Thr Lys 
    1340                 1345         


<210>  1717
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1717

Met Asn Thr His Gln Glu Glu Leu Gln Ser Trp Ile Thr Arg Lys Arg 
1               5                   10                  15      


Leu Pro Asp Thr Glu Met Lys Lys Tyr Trp Ala Ala Tyr Met Asn Leu 
            20                  25                  30          


Ala Arg Leu Asn Phe Phe Lys Thr Leu Met Phe Ile Ser Asn Ser Ile 
        35                  40                  45              


Gly Asp Leu Lys Pro Ala Lys Asp Asn Asn Gly Lys Gly Asn Thr Glu 
    50                  55                  60                  


Val Asn Met His Asn Met Gly Ile Leu Thr Ala Leu Leu Gly Pro Glu 
65                  70                  75                  80  


Asp Glu Glu Lys Ala Arg Leu Leu Ile Phe Lys His Phe Pro Phe Leu 
                85                  90                  95      


Arg Thr Phe Cys Ile Glu Lys Glu Leu Ser Leu Ser Lys Gln Arg Thr 
            100                 105                 110         


Ile Leu Ile Asp Met Ala Cys Ile Ile Gly Arg Tyr Arg Asn Met Tyr 
        115                 120                 125             


Ser His Ser Ile Phe Ile Ser Asp Asp Asn Glu Lys Val Leu Glu Ser 
    130                 135                 140                 


Glu Lys Arg Cys Ser Glu Tyr Leu Gln Ser Ile Leu Thr Val Ser Thr 
145                 150                 155                 160 


Arg Ile Ile Lys Glu Arg Tyr Arg Ser Asn Lys Asn Asp Ala Gln Arg 
                165                 170                 175     


Gly Met Ile Asp Asp Lys Ser Leu Lys Phe Ile Ser Glu Asn Lys Val 
            180                 185                 190         


Lys Phe Val Tyr Asp Glu Asn Gly Lys Arg Ile Thr Ala Pro Asn Lys 
        195                 200                 205             


Lys Tyr Tyr Leu Ser Thr Ile Asp Lys Asp Asn Thr His Leu Ser Tyr 
    210                 215                 220                 


Phe Gly Lys Leu Met Leu Thr Cys Ile Leu Leu Glu Lys Lys Tyr Ala 
225                 230                 235                 240 


Thr Asp Phe Leu Thr Gln Cys His Phe Leu Asp Ala Phe Asn Asp Ser 
                245                 250                 255     


Glu Val Ala Pro Lys Leu Ser Glu Arg Arg Leu Met Leu Glu Val Met 
            260                 265                 270         


Thr Ala Leu Arg Ile Arg Leu Ala Glu Lys Lys Leu Ser Asn Glu Lys 
        275                 280                 285             


Ser Glu Val Gln Ile Ser Leu Asp Ile Leu Asn Glu Leu Lys Lys Cys 
    290                 295                 300                 


Pro Phe Glu Leu Tyr Glu Leu Leu Gly Ser Glu Asp Lys Arg Leu Phe 
305                 310                 315                 320 


Thr Ile Val Ala Asp Thr Gly Glu Thr Ile Leu Leu Arg Arg His Glu 
                325                 330                 335     


Asp Arg Phe Pro Gln Leu Ala Leu Ser Trp Ile Asp Ser Ser Lys Ala 
            340                 345                 350         


Phe Asp His Leu Arg Phe Gln Val Asn Ala Gly Lys Leu Arg Tyr Leu 
        355                 360                 365             


Phe Arg Asp Asn Lys His Cys Ile Asp Gly Gln Thr Arg Met Arg Val 
    370                 375                 380                 


Leu Glu Glu Pro Leu Asn Gly Tyr Arg Arg Leu Met Glu Phe Glu Glu 
385                 390                 395                 400 


Glu Arg Ile Gln Lys Gln Ser Gly Glu Ile Arg Ser Leu Trp Pro Gly 
                405                 410                 415     


Leu Asp Ile Leu Asn Lys Asp Glu Thr Pro Arg Asn Asp Ala Ser Val 
            420                 425                 430         


Leu Pro Tyr Ile Ser Asp Tyr Arg Val Arg Tyr Leu Phe Asp Gly Asp 
        435                 440                 445             


Asn Ile Gly Ile Ser Ile Gly Asp Phe Thr Pro Ser Ile Thr Lys Thr 
    450                 455                 460                 


Asp Glu Thr Lys Tyr Arg Val Thr Gly Lys Thr Ala Asp Cys Cys Leu 
465                 470                 475                 480 


Ser Lys Tyr Glu Leu Pro Gly Leu Leu Phe Tyr His Leu Leu Thr Leu 
                485                 490                 495     


Arg His Gly Asp Asn Lys Arg Ser Thr Lys Asn Ala Glu Asp Ile Ile 
            500                 505                 510         


Ile Asp Ala Ile Lys Arg Tyr Lys Arg Leu Phe Ser Asp Val Lys Glu 
        515                 520                 525             


Gly Ile Leu Lys Pro Ile Lys Glu Gly Asn Ala Asn Gln Leu Gly Asn 
    530                 535                 540                 


Arg Ile Trp Asn Ser Tyr Gly Ile Asp Ile Lys Asp Ile Pro Asp Lys 
545                 550                 555                 560 


Ile Ile Asp Tyr Leu Leu Val Arg Glu Cys Asn Glu Asp Glu Lys Phe 
                565                 570                 575     


Thr Ala Trp Lys Asn Gly Leu Ile Ser Glu Met Leu Gln Ser Thr Lys 
            580                 585                 590         


Asn Arg Ile Lys Arg Phe Glu Lys Asp Ser Glu Ala Val Ile Ser Ser 
        595                 600                 605             


Asp Asn Lys Pro Gly Lys Lys Asn His Val Ser Leu Lys Pro Gly Ala 
    610                 615                 620                 


Tyr Ala Ser Phe Ile Ala Asn Asp Ile Met Phe Phe Gln Glu Cys Gly 
625                 630                 635                 640 


Ala Thr Glu Lys Met Thr Gly Leu Asn Phe Lys Val Met Gln Ser Arg 
                645                 650                 655     


Leu Ala Thr Phe Thr Lys Asp Gly Ser Thr Ser Phe Asn Ile Leu Leu 
            660                 665                 670         


Gln Thr Leu Lys Asn Ala His Leu Val Ser Thr Thr Tyr Gly Lys Gly 
        675                 680                 685             


Asp His Pro Phe Leu Tyr Arg Val Ile Lys Gln Gln Pro Ser Asp Ile 
    690                 695                 700                 


Val Gln Phe Tyr Lys Ile Tyr Leu Asn Glu Lys Val Leu Tyr Leu Gln 
705                 710                 715                 720 


Ser Asp Ile Pro Asp Asn Ala Ile Phe Leu His Gly Glu Arg Lys Arg 
                725                 730                 735     


Trp Glu Asn Arg Asn Glu Gln Tyr Tyr Arg Asp Leu Ala Glu Arg Tyr 
            740                 745                 750         


Leu Gln Arg Pro Ile Gln Leu Pro Arg Gln Leu Phe Glu Ser His Ile 
        755                 760                 765             


Arg Gln Leu Leu Leu Ser Asp Cys Ile Lys Gly Glu Arg Gly Asn Asp 
    770                 775                 780                 


Leu Lys Glu Ala Ile Asn Ser Ala Ala Ser Gln Gly Arg Cys Asn Thr 
785                 790                 795                 800 


Thr Tyr Met Ile Met Glu Tyr Phe Ala Asp Tyr Leu Cys Asp Gly Thr 
                805                 810                 815     


Gln Phe Phe Tyr Gly Leu Phe Asp Gly Asp Leu Ser His Glu Tyr Asn 
            820                 825                 830         


Tyr Arg Phe Tyr Ser Leu Ile Ser Asn Asn Ile Glu Asn Ser Lys Lys 
        835                 840                 845             


Leu Val Leu Thr Leu Lys Lys Gly Asn Asn Ser Lys Glu Ser Pro Phe 
    850                 855                 860                 


Ile Ser Ala Leu Glu Arg Gly Ile His Trp Ser Lys Arg Asn Pro Leu 
865                 870                 875                 880 


Met Lys Lys Gly Leu Lys Asn Asp Ser Ser Glu Gly Asp Phe Val His 
                885                 890                 895     


Ala Ala Lys Arg Ala Tyr Lys Glu Met Thr Glu Thr Glu Arg Met Phe 
            900                 905                 910         


Arg Arg Tyr Ala Val Gln Asp Glu Val Leu Phe Leu Ala Ala Lys Ile 
        915                 920                 925             


Thr Ile Arg Arg Ala Leu Gly Leu Ser Glu Gln Tyr Asn Cys Leu Leu 
    930                 935                 940                 


Gly Asp Ile Lys Pro Gln Gly Gly Ser Leu Leu Glu Gln Thr Ile Pro 
945                 950                 955                 960 


Ser Ile Thr Thr Lys His Thr Ile Asn Thr Gly Asn Lys Lys Gln Lys 
                965                 970                 975     


Pro Lys Gln Val Gln Ile Leu Gln Lys Asn Val Lys Leu Lys Asp Phe 
            980                 985                 990         


Gly Lys Val Phe Lys Leu Leu Asn  Asp Arg Arg Ile Phe  Asp Leu Leu 
        995                 1000                 1005             


Phe Asn  Lys Gly Asn Glu Ala  Val Ser Met Thr Asp  Leu Cys Glu 
    1010                 1015                 1020             


Glu Leu  Glu Arg Tyr Asp Arg  His Arg Val Asp Val  Phe Asp Ser 
    1025                 1030                 1035             


Val Leu  Lys Tyr Glu Ser Lys  Ile Thr Lys Gly Tyr  Thr Asn Lys 
    1040                 1045                 1050             


Glu Leu  Met Asn Glu Ser Gly  Gln Ile Asp Phe Lys  Ala Ile Gln 
    1055                 1060                 1065             


Ala Phe  Asp Lys Gln Asn Thr  Thr Ala Asp Lys Glu  Asp Leu Arg 
    1070                 1075                 1080             


Leu Ile  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Gln Tyr Asn 
    1085                 1090                 1095             


Asn Glu  Pro Ile Leu Phe Asp  Lys Asp Ile Pro Glu  Ile Ala Asp 
    1100                 1105                 1110             


Glu Ile  Ser Ile Ile Ala Lys  Asp Ile Glu Glu Asn  Thr Lys 
    1115                 1120                 1125         


<210>  1718
<211>  1285
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1718

Met Ala Phe Asp Lys Pro Arg Pro Lys Arg Arg Gln Ala Arg Ser Asp 
1               5                   10                  15      


Phe Tyr Ile Thr Asp Lys Ala Ile Met Gly Gly Tyr Phe Asn Leu Ala 
            20                  25                  30          


Gln Leu Asn Phe Phe Lys Thr Leu Met Glu Ile Phe Thr Lys Ala Gly 
        35                  40                  45              


Ile Asp Val Ser Lys Ile Lys Gln Asp Asn Ser Pro Lys Tyr Leu Met 
    50                  55                  60                  


Ile Leu Ile Lys Lys Leu Thr His Asp Asp Glu Lys Ile Asp Asp Lys 
65                  70                  75                  80  


Lys Trp Ala Asp Ala Leu Asp Leu Ser Asn Glu Cys Leu Leu Lys Leu 
                85                  90                  95      


Gln Gln Leu Leu Tyr Lys His Phe Pro Phe Leu Gly Pro Val Met Gly 
            100                 105                 110         


Gly Glu Ala Ser Tyr Asn Ile Tyr Lys Leu Lys Asp Gly His Pro Glu 
        115                 120                 125             


Val Lys Val Ala Asn Asp Val Met Arg Gly Val Lys Leu Glu Asp Cys 
    130                 135                 140                 


Leu Ala Val Val Arg His Phe Ala Leu Cys Leu Asn Asp Cys Arg Asn 
145                 150                 155                 160 


Phe Tyr Thr His Phe Asn Pro Tyr Asn Pro Ile Glu Ala Gln Lys Glu 
                165                 170                 175     


Gln Tyr Leu Ser Gln Asn Lys Val Ala Val Trp Leu Asp Lys Val Lys 
            180                 185                 190         


Asp Ala Ser Arg Arg Ile Ile Lys Gln Asn Asn Gln Leu Thr Ser Gln 
        195                 200                 205             


Asp Met Glu Phe Leu Thr Gly Ile Asp Arg Met Lys Pro Gln Asp Lys 
    210                 215                 220                 


Val Asp Asp Phe Gly Asn Ile Met Thr Asp Arg Arg Gly Arg Pro Ile 
225                 230                 235                 240 


Lys Glu Tyr Val Glu Tyr Glu Asp Tyr Tyr Phe Arg Ile Arg Gly Lys 
                245                 250                 255     


Arg Tyr Leu Val Asp Ala Ala Gly Ala Lys Leu Val Asp Gln Glu Pro 
            260                 265                 270         


Arg Asn Ala Leu Ser Asp Phe Gly Val Val Phe Leu Cys Thr Leu Phe 
        275                 280                 285             


Leu Glu Ser Asp Gln Ala Arg Arg Met Leu Asp Glu Leu Arg Leu Phe 
    290                 295                 300                 


Glu Thr Gly Pro Tyr Asp Gly Ser Arg Asp Gly Asp Glu Phe Lys Asn 
305                 310                 315                 320 


Asp Ile Leu Arg Glu Ile Leu Leu Phe Tyr Arg Thr Arg Val Pro Arg 
                325                 330                 335     


Gly Lys Arg Leu Asp Pro Met Asp Asp Thr Thr Leu Leu Ala Met Asp 
            340                 345                 350         


Met Leu Asn Glu Leu Arg Lys Cys Pro Met Pro Leu Tyr Asp Val Leu 
        355                 360                 365             


Ser Arg Glu Gly Gln Gly Phe Phe Glu Asp Glu Val Lys Arg Pro Asn 
    370                 375                 380                 


Asp Leu Thr Pro Glu Val Ala Lys Arg Leu Arg Ser Ser Asp Arg Phe 
385                 390                 395                 400 


Pro Tyr Leu Ala Leu Arg Tyr Ile Asp Leu Asn Lys Cys Phe Asp Asn 
                405                 410                 415     


Ile Arg Phe Gln Val Gln Leu Gly Lys Phe Arg Tyr Lys Phe Tyr Asp 
            420                 425                 430         


Lys Thr Thr Ile Asp Gly Glu Gln Val Val Arg Gly Leu Gln Lys Glu 
        435                 440                 445             


Val Asn Ala Tyr Gly Arg Leu Gln Asp Val Glu His Tyr Arg Gln Glu 
    450                 455                 460                 


Lys Tyr Ala Asp Met Leu Gln Gln Thr Glu Leu Val Glu Thr Gly Glu 
465                 470                 475                 480 


Glu Asp Ile Thr Ile Ala Asn Phe Ile Pro Asp Thr Pro Gln Ser Ser 
                485                 490                 495     


Ser Tyr Leu Ser Asp Arg Thr Ala Ser Tyr Asn Ile His Asn Asn Arg 
            500                 505                 510         


Ile Gly Leu Phe Trp Asn Met Pro Gly Glu Gln Glu Val Leu Ala Gly 
        515                 520                 525             


Asp Glu Lys Met Tyr Leu Pro Asp Leu Asn Val Asp Asp Asn Gly Lys 
    530                 535                 540                 


Ala Asp Val Phe Leu Pro Ala Pro Lys Ala Ser Leu Ser Val Arg Asp 
545                 550                 555                 560 


Leu Pro Ala Leu Val Phe Tyr Leu Tyr Leu Gln Asn Gln His Pro Asp 
                565                 570                 575     


Leu Thr Pro Ala Glu Ala Ile Ile Gln Gln Lys Tyr Asn Ala Leu Val 
            580                 585                 590         


Ser Phe Phe Glu Asp Val Ser Thr Gly Arg Leu Leu Pro Val Lys Asp 
        595                 600                 605             


Ile Ala Glu Leu Glu Ala Ala Ile Asp Lys Tyr Gly His Leu Thr Val 
    610                 615                 620                 


His Glu Ile Pro Glu Lys Leu Arg Asp Tyr Leu Thr Gly Val Ala Gly 
625                 630                 635                 640 


Thr Glu Asp Asp Asp Asp Cys Ala Asp Arg Leu Asp Cys Tyr Ala Met 
                645                 650                 655     


Gly Ile Leu Glu Lys Arg Tyr Arg Arg Val Ala Ala His Ile Asp Gln 
            660                 665                 670         


Leu Lys Glu Ala Arg Lys Met Val Gly Asp Lys Met Asn Arg Tyr Gly 
        675                 680                 685             


Lys Lys Ser Tyr Ile Asp Val Arg Pro Arg Arg Leu Ala Glu Gln Leu 
    690                 695                 700                 


Ala Gln Ser Ile Val Asp Trp Gln Pro Ala Thr Asp Asn Gly Arg His 
705                 710                 715                 720 


Lys Met Thr Gly Lys Asn Phe Gln Arg Leu Ile Ala Phe Leu Ala Arg 
                725                 730                 735     


Tyr Thr Asp Glu Val Pro Val Gln Glu Ile Lys Asp Leu Met Thr Arg 
            740                 745                 750         


Ala Arg Leu Leu Asp Gly Pro Val Ala His Pro Phe Leu Gln Gln Val 
        755                 760                 765             


Leu Asp Lys Asn Pro Leu Asn Ile Glu Val Leu Tyr Asp Leu Tyr Phe 
    770                 775                 780                 


Lys Glu Glu Lys Leu His Leu Glu Asn Tyr Leu Glu Ile Glu Thr Asn 
785                 790                 795                 800 


Lys Gln Gly Glu Glu Val Phe Arg Lys Lys Ala Ser Val Asp Leu Ser 
                805                 810                 815     


Arg Ile Pro Phe Leu Asn Ser Gly Arg Leu Arg Phe His Lys Arg Asp 
            820                 825                 830         


Ser Ala Ser Phe Gln Arg Leu Ala Ala Arg Tyr Met Gln Val Asp Gly 
        835                 840                 845             


Arg Gln Ser Thr Ile Leu Leu Pro Asp Gly Leu Phe Thr Pro His Ile 
    850                 855                 860                 


Leu Ser Val Leu Lys Ser Glu Tyr Arg Asp Leu Gln Asp His Leu Gln 
865                 870                 875                 880 


Asp Gln Glu Leu Asn Arg Asn Ala Ser Tyr Leu Met Ser Val Tyr Leu 
                885                 890                 895     


Glu Cys Val Leu His Asp Ser Ala Gln Pro Phe Tyr Leu Ser Asn Ser 
            900                 905                 910         


Asn Asp Ser Pro Phe Ala Arg Arg Tyr Asp Leu Phe Ala Ile Leu Gln 
        915                 920                 925             


Asn Lys Lys Lys Gly Ala Glu Leu Leu Pro Asn Pro Leu Ala Pro Val 
    930                 935                 940                 


Glu Ile Asn Arg Arg Leu Thr Ala Lys Thr Pro Asp Gly Ser Ala Lys 
945                 950                 955                 960 


Leu Ile Glu Arg Asp Ile Lys Ala Leu Leu Asp Asp Met Ala Arg Lys 
                965                 970                 975     


Thr Glu Glu Arg Ile His Asp Leu Gln Gln Glu Tyr Ser Arg Lys Lys 
            980                 985                 990         


Glu Lys Gln Ala Gln Glu Glu Arg  Val Lys Leu Glu Arg  Cys Phe Met 
        995                 1000                 1005             


Arg Lys  Ile Ala Asp Val Lys  Lys Gln Ala Gln Glu  Glu Arg Ile 
    1010                 1015                 1020             


Asn Leu  Gln Arg Arg Leu Lys  His Lys Ile Thr Asp  Val Lys Lys 
    1025                 1030                 1035             


Asn Glu  Arg Thr Ile Arg Arg  Tyr Lys Thr Gln Asp  Met Ala Val 
    1040                 1045                 1050             


Phe Leu  Met Ala Lys Gln Met  Leu Ala Asn Gln Leu  Ser Trp Gln 
    1055                 1060                 1065             


Asn Gln  Glu Gly Glu Val Pro  Phe Lys Leu Ala Asn  Val Cys Asn 
    1070                 1075                 1080             


Glu Gly  Phe Leu Arg Gln Thr  Met Lys Val Ser Phe  Pro Tyr Glu 
    1085                 1090                 1095             


Val Pro  Leu Lys Glu Asp Lys  Thr Lys Lys Val Thr  Ile Asp Ile 
    1100                 1105                 1110             


Val Gln  Asp Asn Met Ser Leu  Lys Asn Tyr Gly Leu  Leu Tyr Lys 
    1115                 1120                 1125             


Leu Tyr  His Asp Glu Arg Val  Val Thr Leu Leu Gln  Asn Ile Val 
    1130                 1135                 1140             


Asp Gln  Gln Gln Ile Ser Phe  Ala Glu Leu Thr Ala  Glu Leu Ser 
    1145                 1150                 1155             


Leu Tyr  Asp Gln Asn Arg Ser  Lys Ala Phe Ser Asn  Phe Gln Gln 
    1160                 1165                 1170             


Phe Glu  Lys Leu Ala Phe Glu  Thr Asn Lys Glu Ala  Leu Thr His 
    1175                 1180                 1185             


Pro Glu  His Arg Gly Phe Phe  Leu Glu Lys Val Asn  Lys Lys Asn 
    1190                 1195                 1200             


Gln Val  Ile Arg Tyr Glu Arg  Arg Asn Asn Phe Asp  Ala Leu Leu 
    1205                 1210                 1215             


Asp Leu  Leu Asp Ala Ile Glu  Ala His Gln Leu Asp  Pro Arg Glu 
    1220                 1225                 1230             


Arg Gln  Trp Leu Thr Ser Val  Arg Asn Ala Phe Cys  His Asn Ser 
    1235                 1240                 1245             


Tyr Tyr  Lys Ile Asp Met Gln  Gln Ile Glu Lys Lys  Leu Pro Thr 
    1250                 1255                 1260             


Ile Ile  Gln Gln Ile Val Glu  Ile Val Gln Arg Ile  Thr Asp Lys 
    1265                 1270                 1275             


Ala Ser  His Pro Ser Asn Arg  
    1280                 1285 


<210>  1719
<211>  1138
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1719

Met Glu Thr Leu Tyr Asn Ser Thr Asn Glu Asn Ser Arg Arg Asn Leu 
1               5                   10                  15      


Asn Asp Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Leu Ala Arg Leu 
            20                  25                  30          


Asn Ile Phe Ser Ile Asn Asn His Leu Ala Glu Glu Phe Lys Gln Lys 
        35                  40                  45              


Asn Arg Leu Thr Asp Glu Glu His Ile Arg Asn Ser Phe Ile Cys Asn 
    50                  55                  60                  


Ser Asn Ile Lys Asn Leu Asn Tyr Asn Trp Leu Phe Glu Lys Leu Ile 
65                  70                  75                  80  


Arg Leu Met Pro Ile Val Lys Gln Phe Asp Ser Ser Arg Leu Pro Glu 
                85                  90                  95      


Glu Glu Gln Lys Lys Gly Asp Thr Glu Gly Lys Asn Leu Leu Leu Met 
            100                 105                 110         


Ala Glu Thr Leu Lys Glu Val Phe Lys Asp Ile Gln Asp Phe Arg Asn 
        115                 120                 125             


Asp Tyr Thr His Tyr Tyr Ser Val Glu Lys Gly Asp Glu Arg Lys Leu 
    130                 135                 140                 


Asn Val Ser Ser Ala Thr Ala Asp Phe Leu Val Thr Ser Phe His Arg 
145                 150                 155                 160 


Ala Ile Glu Tyr Thr Lys Ser Arg Phe Ala Asn Val Phe Ser Glu Asp 
                165                 170                 175     


Asp Phe Lys Leu Ile Gln Ala Lys Gln Leu Val Leu Ser Asn Asn Ser 
            180                 185                 190         


Ile Thr Val Glu Gly Leu Val Phe Leu Thr Ala Met Phe Leu Asp Arg 
        195                 200                 205             


Glu Asn Ala Phe Gln Phe Ile Gly Lys Val Gln Gly Leu Lys Gly Thr 
    210                 215                 220                 


Gln Phe Lys Ser Phe Ile Ala Ser Arg Glu Val Leu Met Ala Tyr Cys 
225                 230                 235                 240 


Val Arg Leu Pro His Asp Lys Leu Ile Ser Asp Asp Pro Lys Gln Ala 
                245                 250                 255     


Leu Leu Leu Asp Met Leu Asn Glu Leu Asp Arg Cys Pro Lys Leu Leu 
            260                 265                 270         


Tyr Asn Val Leu Ser Glu Asp Ala Lys Lys Gln Phe Arg Pro Ile Leu 
        275                 280                 285             


Thr Lys Gln Ser Ile Glu Gln Val Leu Glu Asn Ser Val Ser Asp Glu 
    290                 295                 300                 


Glu Arg Glu Asn Ile Leu Asp Asn Ile Asp Tyr Ser Glu Tyr Ile Glu 
305                 310                 315                 320 


Gln Leu Thr Val Arg Val Arg His Ser Asn Arg Phe His Tyr Phe Ala 
                325                 330                 335     


Met Arg Phe Ile Asp Glu Gln Asn Leu Leu Pro Asp Phe Phe Phe Gln 
            340                 345                 350         


Ile Asp Leu Gly Lys Tyr Lys Leu Ser Glu Tyr Glu Lys Ser Ile Leu 
        355                 360                 365             


Gly Gln Ser Ile Pro Arg Ser Ile Ile Glu Asn Ala Lys Ala Phe Gly 
    370                 375                 380                 


Arg Leu Ser Lys Phe Val Ser Glu Asp Asp Val Gln Lys Ile Ile Asp 
385                 390                 395                 400 


Pro Gly Asn Leu Ala Asn Gly Phe Glu Gln Phe Ala Pro His Tyr Asn 
                405                 410                 415     


Thr Asp Ile Asn Lys Ile Gly Phe Arg Phe Asn Glu Asp Ile Cys His 
            420                 425                 430         


Ile Glu Ser Ile Asp Ala Lys Ala Glu Arg Arg Ile Ser Val Asn Leu 
        435                 440                 445             


Ile Gln Pro Gln Pro Met Gly Phe Leu Ser Leu His Glu Leu Ser Lys 
    450                 455                 460                 


Ile Ile Leu Leu Glu Tyr Leu Gln Pro Gly Glu Ser Ile Lys Leu Ile 
465                 470                 475                 480 


Arg Gln Phe Tyr Lys Thr Ala Asn Thr Gln Leu Phe Asn Ile Asp Phe 
                485                 490                 495     


Ile Glu Leu Val Lys Thr Lys Leu Pro Thr Asn Trp Gly Asp Leu Glu 
            500                 505                 510         


Lys Gln Cys Asp Thr Lys Asn Asn Lys Ala Tyr Arg Asn Ser Lys Ala 
        515                 520                 525             


Ser Leu Tyr Glu Leu Gln Lys Arg Lys Glu Glu Leu Asp Lys Val Leu 
    530                 535                 540                 


Gln Phe His Gly Leu Asn Trp Thr Gln Ile Pro Glu Arg Ile Leu Asn 
545                 550                 555                 560 


Tyr Trp Leu Asn Ile Gln Asp Val Ser Tyr Ser Lys Ser Ile Ser Glu 
                565                 570                 575     


Arg Ile Leu Leu Met Lys Arg Asp Gly Leu Lys Arg Leu Lys Gln Leu 
            580                 585                 590         


Lys Asn His Ser Asn Arg Pro Asp Val Arg Ile Pro Lys Val Gly Glu 
        595                 600                 605             


Met Ala Thr Phe Ile Ala Arg Asp Ile Val Asp Met Ile Ile Asp Glu 
    610                 615                 620                 


Glu Lys Lys Lys Lys Ile Thr Ser Ile Tyr Tyr Asp Lys Leu Gln Glu 
625                 630                 635                 640 


Cys Leu Ala Phe Tyr Ala Asp Lys Glu Lys Lys Gln Gln Leu Ile Gly 
                645                 650                 655     


Leu Val Arg Glu Leu Gln Leu Asn Leu Gln Gly Gly His Pro Phe Leu 
            660                 665                 670         


Lys Asn Leu Arg Leu Glu Ser Ile Arg Lys Thr Ser Glu Phe Tyr Glu 
        675                 680                 685             


Leu Tyr Leu Thr Glu Lys Phe Ser Lys Leu Val His Lys Gly Leu Asn 
    690                 695                 700                 


Gln Lys Gly Lys Pro Gln Ser Arg Asp Glu Ser Trp Ile Ile Arg Thr 
705                 710                 715                 720 


Phe Glu Lys Lys Glu Trp Ser Asp Lys Ala Lys Lys Asn Leu Thr Val 
                725                 730                 735     


Tyr Lys Phe Pro Asp Asn Met Lys Glu Leu Pro Phe Ser Met Gln Gln 
            740                 745                 750         


Trp Ile Asn Lys Glu Gln Tyr Asp Leu Arg Gly Trp Leu Arg Asn Ile 
        755                 760                 765             


Asn Glu Gly Arg Asn Arg Asn Asp Gln Lys Arg Pro Ile Asp Leu Pro 
    770                 775                 780                 


Thr Asn Leu Phe Asn Asn Lys Leu Cys Glu Leu Leu Thr Gln Glu Leu 
785                 790                 795                 800 


Arg Leu Ala Gly Lys Ala Ile Pro Asn Thr Thr Lys Tyr Tyr Glu Leu 
                805                 810                 815     


Leu Arg Val Trp Trp Leu Asn Arg Asp Asp Ser Val Gln Gly Phe Tyr 
            820                 825                 830         


Lys Gly Ser Arg Ser Tyr Ile Ile Lys Asp Glu Leu Val Ser Phe Ile 
        835                 840                 845             


Pro Asp Ser Gln Pro Asn Phe Lys Lys Tyr Tyr Gln Glu Pro Leu Asn 
    850                 855                 860                 


Lys Ala Phe Ile Arg Leu Ser Gln Lys Arg Gln Met Asp Arg Glu Lys 
865                 870                 875                 880 


Asp Lys Lys Leu Pro Val Leu Asp Lys Thr Asp Ile Glu Lys Thr Phe 
                885                 890                 895     


Lys Lys Thr Leu Phe Asp Thr Glu Lys Asn Ile Arg Leu Leu Ala Glu 
            900                 905                 910         


Asp Asp Arg Ile Leu Leu Leu Met Ala Glu Lys Leu Ser Pro Gly Asp 
        915                 920                 925             


Gly Ser Gly His Leu Lys Leu Asn Asn Ile Lys Lys Glu Leu Asn Lys 
    930                 935                 940                 


Glu Gln Ile Lys Glu Arg Ala Phe Gln Phe Arg Pro Asn Tyr Asp Asp 
945                 950                 955                 960 


Ala Gly Asn Met Pro Glu Lys Gly Val Leu Leu Pro Glu Ile Gln Leu 
                965                 970                 975     


Ile Val Glu Ala Lys Ile Arg Leu Lys Asn Ile Lys Asp Leu Asn Arg 
            980                 985                 990         


Phe Ala Tyr Asp Arg Arg Leu Pro  Glu Leu Ile Ala Tyr  Leu Pro Asn 
        995                 1000                 1005             


Gly Lys  Ile Gly Val Asn Glu  Leu Arg Tyr Glu Leu  Thr Asp Tyr 
    1010                 1015                 1020             


Asn Lys  Ala Arg Gln Glu Val  Phe Asp Glu Val Phe  Arg Leu Glu 
    1025                 1030                 1035             


Lys Thr  Ile Ile Gln Lys Asp  Ala Asp Gly Leu Leu  Ala Leu Cys 
    1040                 1045                 1050             


Val Asn  Glu Arg Gly Ile Pro  Leu Arg Gly Asn Ile  Ala His Lys 
    1055                 1060                 1065             


Tyr Phe  Leu Gln Trp Leu Ile  Asn His Gly Tyr Ile  Ser Glu Gln 
    1070                 1075                 1080             


Glu Arg  Lys Tyr Leu Asn Met  Ile Arg Asn Ser Phe  Ser His Asn 
    1085                 1090                 1095             


Gln Phe  Pro His Lys Leu Ile  Val Ser Tyr Ser Gln  Asn Gln Ile 
    1100                 1105                 1110             


Asn Gln  Lys Gly Ile Ala Ser  Ile Ile Ser Ser Ala  Phe Lys Glu 
    1115                 1120                 1125             


Lys Thr  Glu Ser Ile Ile Tyr  Lys Ile Asp 
    1130                 1135             


<210>  1720
<211>  1226
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1720

Met Lys Thr Glu Lys Lys Met Phe Val Ile Asp Gly Gln Asn Lys His 
1               5                   10                  15      


Ile Leu Gly Gly Tyr Phe Asn Met Ala Arg Phe Asn Phe Tyr Lys Thr 
            20                  25                  30          


Ile Met Glu Ile Phe Gly Lys Val Gly Ile Lys Gly Asn Tyr Gly Glu 
        35                  40                  45              


Asp Val Ile Asp Arg Val Leu Asp Ala Leu Tyr Lys Val Asn Cys Gly 
    50                  55                  60                  


Asp Glu Asn Gln Leu Asp Asp Glu Gln Lys Glu Trp Ser Lys Lys Lys 
65                  70                  75                  80  


Lys Leu Phe Leu Pro Val Glu Lys Gln Tyr Leu Met Gln Lys Leu Leu 
                85                  90                  95      


Phe Arg Arg Met Pro Phe Phe Gly Pro Ile Met Ala Asp Val Ala Ser 
            100                 105                 110         


Tyr Asn Leu Tyr Lys Thr Lys Lys Ser Gly Val Ile Asn Asp Glu Asp 
        115                 120                 125             


Leu Ala Arg Gly Val Ser Phe Asp Asp Cys Leu Asp Val Leu Arg Ile 
    130                 135                 140                 


Leu Ala Ala Cys Leu Asn Asp Cys Arg Asn Glu Tyr Thr His Phe Lys 
145                 150                 155                 160 


Gln Tyr Asn Thr Ser Val Glu Gln Lys Glu Ile Asp Tyr Arg Lys Asp 
                165                 170                 175     


Lys Val Ala Ile Trp Leu Asp Asp Met Phe Thr Val Ser Arg Arg Val 
            180                 185                 190         


Leu Lys Thr Asp Gly Leu Val Thr Lys Thr Glu Met Glu Phe Leu Thr 
        195                 200                 205             


Gly Ile Glu His Tyr Asp Glu Ile Glu Val Lys Asp Glu Glu Gly Asn 
    210                 215                 220                 


Ile Val Arg Asp Lys Lys Gly Trp Pro Lys Lys Ile His Val Glu Lys 
225                 230                 235                 240 


Glu Asp Phe Phe Phe Lys Ile Lys Lys Asn Val Glu Gly Thr Ser Glu 
                245                 250                 255     


Asp Lys Lys Tyr Lys Thr Leu Thr Asp Phe Gly Val Val Tyr Phe Cys 
            260                 265                 270         


Val Leu Phe Leu Ser Lys Thr Tyr Ala Lys Arg Leu Val Asp Glu Ile 
        275                 280                 285             


Lys Leu Met Lys Gly Ser Lys Phe Lys Gly Val Glu Asn Asp Ile Val 
    290                 295                 300                 


Arg Glu Met Met Ser Leu Tyr Arg Ile Arg Leu Ser Arg Gly Lys Gln 
305                 310                 315                 320 


Leu Asp Val His Asp Thr Ser Thr Ser Leu Ala Leu Asp Met Leu Asn 
                325                 330                 335     


Glu Leu Arg Arg Cys Pro Lys Glu Leu Tyr Asp Val Ile Gly Lys Arg 
            340                 345                 350         


Asp Lys Lys Lys Phe Glu Asp Lys Val Gly Leu Asp Ile Glu Gly Ala 
        355                 360                 365             


Glu Asn Glu Gln Glu Thr Val Ala Arg Ile Arg Tyr Ser Asp Arg Phe 
    370                 375                 380                 


Pro Tyr Leu Val Met Lys Tyr Ile Asp Glu Asn Glu Leu Phe Glu Arg 
385                 390                 395                 400 


Ile Arg Phe His Ile Arg Leu Gly Asn Tyr Arg Phe Glu Phe Tyr Asn 
                405                 410                 415     


Lys Thr Cys Ile Asn Gly Asp Asp Gln Val Arg Ser Leu Gln Lys Glu 
            420                 425                 430         


Ile Asn Gly Phe Gly Arg Ile His Gln Leu Glu Glu Lys Arg Lys Glu 
        435                 440                 445             


Met Tyr Lys Asp Met Phe Gln Glu Lys Glu Tyr Glu Ser Lys Lys Leu 
    450                 455                 460                 


Glu His Glu Asp Leu Tyr Leu Asp Leu Leu Gln Asn Lys Glu Asp Ala 
465                 470                 475                 480 


Ile Asp Thr Lys Pro Tyr Ile Thr Asp His Glu Ala Tyr Tyr Asn Ile 
                485                 490                 495     


Phe Ser Asn Arg Ile Gly Leu Tyr Trp Glu Asn Thr Trp Asn Pro Ser 
            500                 505                 510         


Glu Tyr Val Leu Leu Ser Lys Asp Lys Lys Gly Leu Tyr Leu Pro Ser 
        515                 520                 525             


Leu Ala Asp Val Gln Asp Gly Arg Val Asp Met Pro Ala Pro Lys Ala 
    530                 535                 540                 


Met Leu Ser Val Phe Asp Phe Pro Ala Met Met Phe Tyr Glu Tyr Leu 
545                 550                 555                 560 


Gln Lys Ala Asn Gly Gly Val Lys Val Glu Asp Val Ile Ile Asn Lys 
                565                 570                 575     


Tyr Asn Ala Leu Lys Glu Phe Phe Ser Asp Val Tyr Asn Gly Lys Thr 
            580                 585                 590         


Lys Glu Glu Leu Lys Ser Lys Ile Glu Ser Ser Gly Leu Arg Ile Ser 
        595                 600                 605             


Glu Ile Pro Glu Lys Leu Arg Asp Tyr Leu Ser Ser Glu Lys Glu Tyr 
    610                 615                 620                 


Asp His Asn Lys Glu Leu Lys Lys His Ala Leu Gly Leu Leu Lys Asn 
625                 630                 635                 640 


Arg Tyr Leu Asp Leu Leu Asp Arg Arg Lys Asn Tyr Lys Glu Asp Arg 
                645                 650                 655     


Lys Arg Ile Gly Glu Lys Asp Asn Lys Tyr Gly Lys Lys Gly Phe Arg 
            660                 665                 670         


Asp Val Arg Tyr Gly Lys Leu Gly Glu Tyr Leu Ser Arg Ser Val Met 
        675                 680                 685             


Asp Trp Leu Pro Lys Asp Ser Glu Ala Asn Ala Lys Leu Thr Gly Leu 
    690                 695                 700                 


Asn Tyr Ser Lys Leu Gln Ala Phe Phe Ala Thr Tyr Gly Pro Arg Lys 
705                 710                 715                 720 


Thr Phe Asp Glu Leu Asp Ser Val Cys Lys Glu Ala His Leu Asp Gln 
                725                 730                 735     


His Pro Phe Leu Lys Tyr Val Leu Asn Lys Lys Pro Asn Gly Ile Glu 
            740                 745                 750         


Pro Leu Tyr Leu Ala Tyr Ile Asn Ser Glu Ile Ile Gln Leu Glu Lys 
        755                 760                 765             


Tyr Leu Asp Thr Lys Asn Leu Glu Lys Ile Glu Leu Lys Glu Gly Ala 
    770                 775                 780                 


Asp Phe Ser Asp Ile Pro Phe Ile His His Asp Arg Lys Arg Trp Glu 
785                 790                 795                 800 


Lys Arg Asn Glu Gln Tyr Tyr Arg Asp Leu Ala Gly Arg Tyr Leu Arg 
                805                 810                 815     


Ile Gly Gly Gln Gly Lys Glu Lys Asp Lys Val Lys Glu Val Pro Met 
            820                 825                 830         


Asn Leu Pro Asp Gly Leu Phe Thr Pro Tyr Ile Leu Lys Leu Leu Lys 
        835                 840                 845             


Glu Lys Tyr Ala Asn Asn Lys Glu Leu Gln Glu Lys Ile Lys Asp Glu 
    850                 855                 860                 


Lys Leu Gly Ser Ile Val Lys Gly Lys Glu Glu Lys Leu Asn Gly Asn 
865                 870                 875                 880 


Ala Ala Tyr Leu Ile Ser Ser Phe Phe Glu Cys Val Leu Lys Asp Lys 
                885                 890                 895     


Ser Gln Glu Tyr Tyr Thr Tyr Lys Arg Ser Tyr Glu Leu Phe Asn Lys 
            900                 905                 910         


Leu Asp Asn Asp Glu Lys Ser Leu Thr Thr Asp Glu Ile Asn Glu Arg 
        915                 920                 925             


Leu Lys Arg Gly Asp Val Glu Lys Pro Lys Pro Ile Gln Lys Glu Ile 
    930                 935                 940                 


Glu Arg Phe Gly Asp Ala Ile Lys Lys Phe Asp Arg Arg Asn His Lys 
945                 950                 955                 960 


Thr Leu Gln Glu Ala Gln Glu Ala Met Lys Lys Lys Leu Thr Gly Leu 
                965                 970                 975     


Ile Gln Glu Val Lys Met Asn Glu Arg Ala Ile Arg Arg Tyr Lys Thr 
            980                 985                 990         


Glu Asp Ala Ile Leu Phe Leu Met  Ala Lys Arg Thr Leu  Ser Gly Thr 
        995                 1000                 1005             


Ile Leu  Ala Gly Gln Asp Asp  Gln Leu Phe Met Leu  Lys Asp Val 
    1010                 1015                 1020             


Phe Thr  Asp Thr Phe Leu Asn  Gln Thr Phe Asp Phe  Glu Phe Pro 
    1025                 1030                 1035             


Ile Lys  Val Asp Gly Asn Asp  Arg Gln Ile Thr Ile  Lys Gln Asn 
    1040                 1045                 1050             


Gly Met  Ser Leu Lys Asn Tyr  Gly Glu Phe His Arg  Leu Leu Ala 
    1055                 1060                 1065             


Asp Asp  Arg Met Pro Ser Leu  Val Asn Leu Leu Leu  Asp Lys Lys 
    1070                 1075                 1080             


Val Thr  Glu Val Glu Tyr Ser  Asn Leu Trp Gly Glu  Leu Thr Ser 
    1085                 1090                 1095             


Tyr Asp  Ile Ser Arg Ser Ser  Ile Phe Lys Ala Ala  Gln Asp Phe 
    1100                 1105                 1110             


Glu Lys  Gln Ile Leu Glu Leu  His Pro Leu Asn Asp  Pro Asn Asp 
    1115                 1120                 1125             


Asn Arg  Phe Tyr Ile Asp Asn  Asp Pro Thr Lys Leu  Ala Arg Arg 
    1130                 1135                 1140             


Asn Asn  Phe Arg Ser Leu Leu  Asp Leu Leu Asp Gly  Asn Leu Leu 
    1145                 1150                 1155             


Ser Tyr  Glu Asp Lys Glu Leu  Val Ile Ser Ile Arg  Asn Ala Phe 
    1160                 1165                 1170             


Cys His  Asn His Tyr Pro Met  Lys Leu Asp Val Glu  Val Asp Lys 
    1175                 1180                 1185             


Thr Arg  Ile Gly Asp Thr Glu  Gly Arg Ala Ala Gly  Glu Thr Thr 
    1190                 1195                 1200             


Thr Ile  Ala Thr Leu Ile Lys  Asn Lys Met Lys Glu  Leu Cys Glu 
    1205                 1210                 1215             


Ser Ile  Asn Leu Gln Ile Asn  Asn 
    1220                 1225     


<210>  1721
<211>  1221
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1721

Met Asp Ile Arg Leu Ser Lys Asn Arg Ala Leu Leu Ala Ala Tyr Leu 
1               5                   10                  15      


Asn Met Ala Gln Gln Asn Val Tyr Val Thr Leu Leu His Ile Ser Gln 
            20                  25                  30          


Leu Met Gly Val Glu Glu Thr Lys Asp Leu Ser Asn Arg Met Tyr Asp 
        35                  40                  45              


Phe Gln Ile Leu Gln Glu Leu Lys Thr Gly Lys Lys Gly Ala Glu Ser 
    50                  55                  60                  


Glu Gln Met Val Lys Ser Glu Arg Val Gln Lys Ile Ile Leu Leu Leu 
65                  70                  75                  80  


Tyr Arg Asn Phe Pro Phe Leu Lys Ala Phe Val Glu Ala Lys Tyr Lys 
                85                  90                  95      


Gln Gln Glu Lys Asn Asn Gly Gly Lys Asn Lys Gly Gly Gly Lys Asn 
            100                 105                 110         


Thr Gln Lys Asn Lys Asn Asn Ala Ser Asn Glu Glu Gln Leu Glu Phe 
        115                 120                 125             


Thr Glu Ser Glu Leu Gly Lys Leu Pro Ile Pro Pro His Glu Tyr Arg 
    130                 135                 140                 


Thr Ile Leu Cys Asp Val Phe Arg Leu Ile Asn Asp Leu Arg Asn Glu 
145                 150                 155                 160 


Tyr Thr His Phe Ser Pro Glu Lys Arg Thr Gly Gly Ala Lys Glu Ser 
                165                 170                 175     


His Glu Lys Cys Gln Lys Lys Met Leu Ser Tyr Leu Tyr Leu Cys Leu 
            180                 185                 190         


Asp Gly Gly Arg Arg Val Val Lys Glu Arg Phe Lys Asp Thr Phe Gln 
        195                 200                 205             


Glu Asn Asp Phe Asn Phe Leu Thr Gln Gly Pro Arg Tyr Ser Leu Gln 
    210                 215                 220                 


Lys Asp Gly Asp Lys Lys Lys Ala Glu Glu Arg Pro Asn Phe Tyr Tyr 
225                 230                 235                 240 


Arg Leu Lys Asp Asp Gln Gly Leu Phe Ser Tyr Val Gly Ile Leu Leu 
                245                 250                 255     


Phe Ile Ser Leu Phe Leu His Lys Arg Tyr Ile Ser Glu Met Leu Ala 
            260                 265                 270         


Gln Ser Gly Leu Phe Tyr Thr Pro Arg Tyr Trp Lys Gly Gln Pro Val 
        275                 280                 285             


Asn Val Glu Leu Glu Arg Arg Ile Ile Ser Glu Ile Phe Ser Ile Tyr 
    290                 295                 300                 


Arg Ile Arg Leu Pro Lys Glu Arg Ile Asp Ser Thr Arg Pro Asp Tyr 
305                 310                 315                 320 


Ala Leu Gly Leu Asp Met Leu Asn Glu Leu Gln Lys Cys Pro Asn Glu 
                325                 330                 335     


Leu Tyr Glu Thr Phe Ser Pro Lys Asp Gln Ala Glu Phe Arg Val Lys 
            340                 345                 350         


Arg Glu Tyr Asp Glu Ser Gly Glu Gly Thr Glu Glu Gly Glu Val Leu 
        355                 360                 365             


Leu Lys Arg Phe Glu Asp Arg Phe Pro Tyr Phe Ala Ile Arg Tyr Leu 
    370                 375                 380                 


Asp Glu Asn Arg Val Phe Asp Asp Ile Arg Phe Gln Val Ser Ile Gly 
385                 390                 395                 400 


Lys Tyr Arg Tyr Lys Phe Tyr Asn Lys Leu Cys Ile Asp Val Val Ser 
                405                 410                 415     


Ser Asn Arg Asn Asp Asp Cys Tyr Arg Leu Arg Ser Leu Gln Lys Glu 
            420                 425                 430         


Ile Asn Gly Phe Gly Arg Leu Asn Glu Val Glu Tyr Glu Arg Ile Leu 
        435                 440                 445             


Arg Tyr Gly Ser His Ile His Val Glu Lys Pro Glu Gly Asp Asp Thr 
    450                 455                 460                 


Pro Tyr Leu Thr Asp His His Thr Ser Tyr Leu Phe Asn Gly Asn Arg 
465                 470                 475                 480 


Ile Gly Leu Leu Phe Asn Gln Glu Asn Gly Arg His Asp Leu Glu Glu 
                485                 490                 495     


Ile Arg Gly Asn Cys Leu Tyr Leu Pro His Leu Thr Phe Ala Ser Ser 
            500                 505                 510         


Ser Glu Gly Lys Asp Ala Arg Arg Val Pro Pro Ile Ala Trp Leu Ser 
        515                 520                 525             


Thr Tyr Glu Leu Pro Ala Leu Ile Phe His His Leu Leu Cys Arg His 
    530                 535                 540                 


Tyr Gly Leu Glu Arg Thr Ala Thr Glu Ser Ile Ile Lys Glu Cys Val 
545                 550                 555                 560 


Gly Leu Tyr His Arg Leu Phe Thr Asp Ile Arg Asp Gly Lys Leu Leu 
                565                 570                 575     


Pro Gly Glu Ala Leu Gly Ile Gln Ala Glu Glu Ser Thr Arg Ser Glu 
            580                 585                 590         


Ile Ser Arg Ile Lys Lys Gly Glu Pro Leu Pro Gln Asn Ile Ser Glu 
        595                 600                 605             


Lys Ile Glu Thr Phe Leu Ser Thr His Tyr Cys Thr Glu Gln Val Cys 
    610                 615                 620                 


Leu His Ile Gln Asp Ile Pro Lys Lys Ile Ile Asp Tyr Leu Ile Gly 
625                 630                 635                 640 


Lys Asn Ile Asp Gln Asp Met Ser Gly Leu Phe Lys Gln Arg Ser Arg 
                645                 650                 655     


Glu Arg Ile Asn Lys Met Tyr Glu Ser Thr Lys Ile Arg Leu Lys Lys 
            660                 665                 670         


Phe Lys Thr Asp Leu Asp Leu Gln Gly Asn Gly Asp Asn Lys Phe Gly 
        675                 680                 685             


Lys Lys Arg Tyr Thr Asp Ile Arg Pro Gly Gln Leu Ala Asp Tyr Leu 
    690                 695                 700                 


Ala Lys Asp Leu Leu Phe Phe Gln Pro Tyr Asp Asp Glu Lys Lys Asn 
705                 710                 715                 720 


Lys Val Thr Gly Leu Asn Tyr Gln Ile Leu Gln Ala Ala Leu Ala Ile 
                725                 730                 735     


Tyr Asn His Asn Leu Asp Glu Leu Arg Arg Leu Phe Lys Asn Ala Arg 
            740                 745                 750         


Leu Leu Val Pro Glu Asn Pro Lys Met Glu His Pro Phe Leu Gly Ser 
        755                 760                 765             


Val Leu His Lys Ser Pro Arg Thr Thr Leu Gln Phe Tyr Ala Tyr Tyr 
    770                 775                 780                 


Leu Leu Glu Lys Ile Ser Tyr Leu Lys Lys Arg Leu Asp Asp Pro Asn 
785                 790                 795                 800 


Glu Thr Phe Ala Asp Leu Phe Arg Tyr Lys Gln Arg Gln Lys Trp Gln 
                805                 810                 815     


Thr Arg Asp Ser Gln Trp Tyr Arg Ala Leu Ala Gly Arg Tyr Met Ala 
            820                 825                 830         


Glu Met Met Glu Glu Gly Thr Met Asn Phe Lys Pro Val Glu Leu Pro 
        835                 840                 845             


Arg Gly Leu Phe Glu Arg Pro Ile Lys Arg Leu Leu Thr Asn Ile Leu 
    850                 855                 860                 


Thr Lys Arg Thr Asp Ser Asp Ser Gln Ala Leu Leu Lys Ile Val Glu 
865                 870                 875                 880 


Ser Pro Arg Cys Asn Val Ser Tyr Leu Ile Ala Gln Tyr Phe Thr Leu 
                885                 890                 895     


Ile Leu His Asp Asp Ser Gln Pro Phe Tyr His Pro Asn Lys Arg Tyr 
            900                 905                 910         


Lys Arg Thr Tyr Gln Tyr Phe Asn Ile Leu Asn Asn Arg Lys Glu Arg 
        915                 920                 925             


Asn Lys Leu Val Gln Val Tyr Tyr Thr Leu Asp Glu Met Glu Ala Tyr 
    930                 935                 940                 


Phe Lys Asp Thr Glu Ser Leu Lys Lys Arg Tyr Lys Asp Tyr Leu Thr 
945                 950                 955                 960 


Ser Ser Glu Ala Lys Lys His Pro Ala Pro Glu Gln Arg Leu Lys Lys 
                965                 970                 975     


Tyr Leu Ser Glu Tyr Arg Lys Asn Glu Thr Thr Ile Arg Arg Tyr Arg 
            980                 985                 990         


Val Gln Asp Met Leu Val Phe Leu  Met Ala Lys Ile Leu  Leu Leu Glu 
        995                 1000                 1005             


Lys Gly  Gly Leu Glu Ala Gly  Glu Leu Glu Gln Tyr  Lys Leu Ser 
    1010                 1015                 1020             


His Ile  Gln Pro Thr Thr Gly  Gln Asn Ser Gly Gln  Asn Ile Leu 
    1025                 1030                 1035             


Ser Leu  Gln Val Pro Phe Asn  Ile Thr Val Lys Leu  Asp Asp Gly 
    1040                 1045                 1050             


Thr Glu  Arg Ser Ile Thr Gln  Glu Ala Ile Lys Val  Lys Asn Tyr 
    1055                 1060                 1065             


Gly Asp  Phe Phe Arg Phe Leu  Tyr Asp Asp Arg Val  Ala Ser Leu 
    1070                 1075                 1080             


Leu Pro  Tyr Thr Gln Glu Asp  Ile Pro Leu Glu Arg  Ala Leu Leu 
    1085                 1090                 1095             


Glu Lys  Glu Leu Glu Gly Tyr  Asp Arg Glu Arg Ile  Pro Ile Phe 
    1100                 1105                 1110             


Lys Ser  Val His Cys Met Glu  Lys Glu Ile Leu Arg  Leu Cys Pro 
    1115                 1120                 1125             


Glu Leu  Asn Asp Pro Gln Ser  Ser Gln Tyr Lys Tyr  Thr Thr Asp 
    1130                 1135                 1140             


Ile Gly  Thr Glu Lys Ile Val  Lys Glu Asn Phe Arg  Ala Met Leu 
    1145                 1150                 1155             


Thr Glu  Leu Cys Ser Arg Gly  Leu Leu Pro Glu Asn  Glu Ile Glu 
    1160                 1165                 1170             


Met Met  Val Glu Ile Arg Asn  Ser Phe Ser His Asn  Arg Tyr Ala 
    1175                 1180                 1185             


Cys Val  Asn Leu Lys Gly Lys  Asn Ile Pro Met Ile  Ala Ile Ser 
    1190                 1195                 1200             


Ile Gln  Arg Lys Phe Asp Gly  Val Val Gly Arg Thr  Ile Gly Lys 
    1205                 1210                 1215             


Asn Lys  Asn 
    1220     


<210>  1722
<211>  1199
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1722

Met Asn Thr Phe Ile Asp Ser Phe Ile Arg Arg Val Gln Ile Gln Asn 
1               5                   10                  15      


Gln Asn Gln Ser Trp Pro Lys Arg Pro Lys Tyr Val Arg Pro Val Glu 
            20                  25                  30          


Asn Ile Arg Pro Asp Asp Leu Ala Phe Gln Ser His Phe Thr Ala Tyr 
        35                  40                  45              


Leu Asn Met Ala Arg Gln Asn Cys Cys Ile Ile Leu Gly His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Gly Phe Lys Ala Ser Ser Val Lys Asp Thr Thr Leu Thr 
65                  70                  75                  80  


Ser Ser Pro Leu Leu Gly Gln Asn Gly Leu Leu Ser Pro Lys Lys Glu 
                85                  90                  95      


Val Ser Asp Leu Ile Arg Gly Arg Leu Leu Ser Ala Phe Pro Met Leu 
            100                 105                 110         


Asp Pro Met Ile Arg Tyr Arg Lys Ala Val Asp Lys Glu Lys Asp Asp 
        115                 120                 125             


Tyr Ala Arg Ile Ile Ile Thr Ser Glu Asp Val Ser Glu Met Leu Arg 
    130                 135                 140                 


Asp Leu Leu Asp Val Leu Ser Tyr Tyr Arg Asp Met Ala Ser His Val 
145                 150                 155                 160 


Val Phe Asn Asp Asp Arg Ser Val Ser Ala Glu Phe Ala Ser Lys Glu 
                165                 170                 175     


Lys Lys Val Ala Glu Cys Leu Asn Tyr Met Met Thr Val Ser Leu Arg 
            180                 185                 190         


Ile Val Lys Asp Arg Phe Ser Leu Ala Val Ser Asp Leu Asp Phe Tyr 
        195                 200                 205             


Asn Arg Asn Arg Tyr Met Met Val Asn Arg Lys Pro Leu Leu Asn Ala 
    210                 215                 220                 


Gly Phe Ala His Ala Val Arg Thr Glu Asp Tyr Arg Leu Thr Leu Met 
225                 230                 235                 240 


Gly Leu Val Leu Leu Cys Cys Gln Phe Ile Glu Lys Gln Tyr Ala Ser 
                245                 250                 255     


Met Phe Phe Asp Ala Leu Asp Lys His Ser Asn Gly Ala Arg Phe Tyr 
            260                 265                 270         


Gly Ile Ala Asp Ala Met Pro Met Val Asn Val Gly Thr Lys Asp Lys 
        275                 280                 285             


Pro Lys Lys Ile Pro Met Tyr Thr Gly Asp Glu Ala Gln Lys Gln Val 
    290                 295                 300                 


Gln Lys Gln Arg Met Ala Leu Arg Glu Ala Tyr Ser Val Tyr Arg Val 
305                 310                 315                 320 


Arg Ile Pro Lys Glu Arg Leu Glu Ser Thr Arg Ser Asp Met Ala Leu 
                325                 330                 335     


Ala Leu Asp Ile Leu Asn Glu Leu Gly Lys Cys Pro Glu Glu Leu Phe 
            340                 345                 350         


Glu His Leu Ser Pro Glu Asp Arg Glu Ser Phe Lys Asn Glu Glu Gly 
        355                 360                 365             


Val Leu Met Lys Arg Tyr Ser Asp Arg Phe Pro Gln Leu Ala Leu Arg 
    370                 375                 380                 


Trp Leu Asp Glu Asn Glu Lys Phe Asn Asn Leu Arg Phe His Val Thr 
385                 390                 395                 400 


Phe Gly Lys Tyr Arg Trp Leu Phe Cys Gln Asp Lys Lys Cys Ala Asp 
                405                 410                 415     


Gly Ser Val Arg Pro Arg Trp Leu Gln Lys Glu Leu Asn Gly Phe Gly 
            420                 425                 430         


Arg Ile Gln Thr Val Glu Arg Lys Arg Thr Gly Leu Glu Pro Gly Trp 
        435                 440                 445             


Asp Gly Thr Gly Leu Ile Arg Lys Phe Glu Glu Val Val Thr Asp Glu 
    450                 455                 460                 


Val Gln Lys Glu Pro Tyr Ile Thr Asp Phe Arg Thr Gln Tyr Leu Phe 
465                 470                 475                 480 


Asn Arg Asp Lys Ile Gly Ile Ser Leu Ser Glu Tyr Met Pro Gly Ile 
                485                 490                 495     


Gly Asp Ile His Ser Gly Lys Glu Trp Gly Lys His Ala Gly Val Pro 
            500                 505                 510         


Asp Phe Tyr Leu Ser Val Tyr Asp Ile Pro Ala Met Leu Phe Leu Thr 
        515                 520                 525             


Trp Leu Leu Gly Lys Asn Ser Ser Ala Val Glu Lys Leu Leu Ala Asn 
    530                 535                 540                 


Cys Lys Ala Ala Tyr Met Lys Leu Phe Asp Asp Leu Ala Lys Gly Lys 
545                 550                 555                 560 


Trp Glu Gly Glu Arg Asn Val Ser Asp Tyr Cys Ala Gly Glu Gly Thr 
                565                 570                 575     


Val Arg Tyr Thr Leu Arg Trp Tyr Asp Val Pro Met Lys Ile Arg Arg 
            580                 585                 590         


Lys Met Pro Leu Leu Gly Gly Asp Arg Asp Phe Glu Glu Lys Lys Ser 
        595                 600                 605             


Phe Glu Thr Leu Ala Gln Glu Ala Leu Thr Arg Met Leu Gln Arg Thr 
    610                 615                 620                 


Glu Asn Gln Leu Glu Lys Phe Asp Arg Asp Leu Ala Ala Ala Arg Asp 
625                 630                 635                 640 


Leu Lys Ala Asn Lys Gln Gly Lys Asp Arg Phe Val Asp Ile Arg Ala 
                645                 650                 655     


Gly Ser Leu Ala Thr Phe Leu Ala Arg Asp Ile Val Arg Leu Met Pro 
            660                 665                 670         


Val Ser Asp Asn Gly Arg Asn Lys Pro Thr Gly Leu Asn Tyr Ser Ile 
        675                 680                 685             


Val Gln Lys Ala Ile Ala Thr Tyr Lys Pro Ser Glu Gly Gly Leu Asp 
    690                 695                 700                 


Thr Leu Thr Gly Val Phe Arg Asp Ala Arg Ile Ile Gly Val Lys Gly 
705                 710                 715                 720 


Gly Ser His Pro Phe Leu Glu Arg Leu Leu Val Glu Lys Lys Pro Ser 
                725                 730                 735     


Ser Val Leu Ala Leu Tyr Arg His Tyr Leu Glu Tyr Arg Lys Glu Tyr 
            740                 745                 750         


Leu Lys Lys Ala Leu Glu Asp Glu Asn Lys Ala Glu Leu Lys Asn Leu 
        755                 760                 765             


Pro Phe Leu Lys Ser Gly Arg Gln Lys Tyr Ala Val Asp Gln Ala Asp 
    770                 775                 780                 


Tyr Ala Arg Arg Leu Ala Glu Ser Tyr Arg Asn Cys Pro Ile Tyr Leu 
785                 790                 795                 800 


Pro Thr Gly Ile Phe Thr Asp Met Leu Lys Asp Gln Leu Ala Lys Ile 
                805                 810                 815     


Asp Val Met Lys Pro Val Leu Glu Asn Asp Lys Val Asn Ala Ser Tyr 
            820                 825                 830         


Leu Ile Ala Gln Tyr Phe Glu Lys Val Glu His Asp Ser Glu Gln Pro 
        835                 840                 845             


Leu Tyr Arg Leu Lys Arg Asn Tyr Arg Val Phe Asp Leu Leu Glu Phe 
    850                 855                 860                 


Thr Asp Glu Pro Lys Tyr Trp Arg Leu Asn Glu Arg Ser Asp Lys Ala 
865                 870                 875                 880 


Gly Lys Tyr Gly Leu Ala Lys Arg Asn Ile Phe Trp Asn Arg Met Gly 
                885                 890                 895     


Glu Tyr Tyr Lys Gly Leu Lys Lys Phe Tyr Lys Gly Tyr Glu Ser Lys 
            900                 905                 910         


Arg Thr Ala Val Asp Trp Arg Glu Lys Leu Lys Ile Val Glu Ala Glu 
        915                 920                 925             


His Ala Met Trp Asn Arg Leu Lys Asp Ala Ser Gly Glu Ala Arg Leu 
    930                 935                 940                 


Lys Met Lys Asp Gly Val Phe Tyr Ser Arg Leu Leu Ser Ala Arg Lys 
945                 950                 955                 960 


Glu Tyr Asp Asp Cys Glu Arg Ala Leu Arg Arg Leu Lys Val Gln Asp 
                965                 970                 975     


Ile Val Leu Phe Leu Ala Ala Arg Glu Thr Leu Ile Leu Pro Lys Asp 
            980                 985                 990         


Lys Val Phe Arg Leu Lys Asn Leu  Ser Leu Ser Glu Gly  Asn Lys Asn 
        995                 1000                 1005             


Ile Leu  Ser Ser Ala Ile Asp  Glu Phe Ser Val Asp  Val Val Trp 
    1010                 1015                 1020             


Thr Glu  Lys Glu Gly Ala Ala  Lys Val Thr His Ser  Ala Ser Ile 
    1025                 1030                 1035             


Lys Glu  Asn Asp Val Val Ile  Lys Asn Tyr Gly Arg  Met Phe Arg 
    1040                 1045                 1050             


Leu Leu  His Asp Asp Arg Val  Lys Thr Leu Leu Pro  His Ile Tyr 
    1055                 1060                 1065             


Asp Ser  Ala Leu Ser Glu Asn  Ile Thr Gly Asp Arg  Ile Thr Val 
    1070                 1075                 1080             


Lys Asp  Asn Lys Val Ile Ile  Asp Lys Ser Leu Phe  Asp Glu Asp 
    1085                 1090                 1095             


Leu Met  Asn Tyr Asp Leu Arg  Arg His Glu Ile Cys  Glu Ile Ile 
    1100                 1105                 1110             


Leu Arg  Phe Glu Ala Ala Ser  Ile Lys Arg Phe Gly  Leu Asp Gly 
    1115                 1120                 1125             


Arg Val  Asp Phe Lys Ala Ala  Leu Asp Ala Leu Thr  Gly Arg Ser 
    1130                 1135                 1140             


Leu Leu  Asn Asp Glu Asp Ala  Arg Ile Leu Ser Ala  Ile Arg Asn 
    1145                 1150                 1155             


Ala Tyr  Asn His Asn Lys Tyr  Pro Ala Lys Gly Thr  Asp Val Lys 
    1160                 1165                 1170             


Val Asn  Val Met Ala Leu Pro  Lys Leu Thr Glu Asp  Leu Leu Arg 
    1175                 1180                 1185             


Ile Phe  Ser Asp Thr Gly Asn  Asn Arg Val Arg 
    1190                 1195                 


<210>  1723
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1723

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Leu Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1724
<211>  1199
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1724

Met Asn Thr Phe Ile Asp Ser Phe Ile Arg Arg Val Gln Ile Gln Asn 
1               5                   10                  15      


Gln Asn Gln Ser Trp Pro Lys Arg Pro Lys Tyr Val Arg Pro Val Glu 
            20                  25                  30          


Asn Ile Arg Pro Asp Asp Leu Ala Phe Gln Ser His Phe Thr Ala Tyr 
        35                  40                  45              


Leu Asn Met Ala Arg Gln Asn Cys Cys Ile Ile Leu Gly His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Gly Phe Lys Ala Ser Ser Val Lys Asp Thr Thr Leu Thr 
65                  70                  75                  80  


Ser Ser Pro Leu Leu Gly Gln Asn Gly Leu Leu Ser Pro Lys Lys Glu 
                85                  90                  95      


Val Ser Asp Leu Ile Arg Gly Arg Leu Leu Ser Ala Phe Pro Met Leu 
            100                 105                 110         


Asp Pro Met Ile Arg Tyr Arg Lys Ala Val Asp Lys Glu Lys Asp Asp 
        115                 120                 125             


Tyr Ala Arg Ile Ile Ile Thr Ser Glu Asp Val Ser Glu Met Leu Arg 
    130                 135                 140                 


Asp Leu Leu Asp Val Leu Ser Tyr Tyr Arg Asp Met Ala Ser His Val 
145                 150                 155                 160 


Val Phe Asn Asp Asp Arg Ser Val Ser Ala Glu Phe Ala Ser Lys Glu 
                165                 170                 175     


Lys Lys Val Ala Glu Cys Leu Asn Tyr Met Met Thr Val Ser Leu Arg 
            180                 185                 190         


Ile Val Lys Asp Arg Phe Ser Leu Ala Val Ser Asp Leu Asp Phe Tyr 
        195                 200                 205             


Asn Arg Asn Arg Tyr Met Met Val Asn Arg Lys Pro Leu Leu Asn Ala 
    210                 215                 220                 


Gly Phe Ala His Ala Val Arg Thr Glu Asp Tyr Arg Leu Thr Leu Met 
225                 230                 235                 240 


Gly Leu Val Leu Leu Cys Cys Gln Phe Ile Glu Lys Gln Tyr Ala Ser 
                245                 250                 255     


Met Phe Phe Asp Ala Leu Asp Lys His Ser Asn Gly Ala Arg Phe Tyr 
            260                 265                 270         


Gly Ile Ala Asp Ala Met Pro Met Val Asn Val Gly Thr Lys Asp Lys 
        275                 280                 285             


Pro Lys Lys Ile Pro Met Tyr Thr Gly Asp Glu Ala Gln Lys Gln Val 
    290                 295                 300                 


Gln Lys Gln Arg Met Ala Leu Arg Glu Ala Tyr Ser Val Tyr Arg Val 
305                 310                 315                 320 


Arg Ile Pro Lys Glu Arg Leu Glu Ser Thr Arg Ser Asp Met Ala Leu 
                325                 330                 335     


Ala Leu Asp Ile Leu Asn Glu Leu Gly Lys Cys Pro Glu Glu Leu Phe 
            340                 345                 350         


Glu His Leu Ser Pro Glu Asp Arg Glu Ser Phe Lys Asn Glu Glu Gly 
        355                 360                 365             


Val Leu Met Lys Arg Tyr Ser Asp Arg Phe Pro Gln Leu Ala Leu Arg 
    370                 375                 380                 


Trp Leu Asp Glu Asn Glu Lys Phe Asn Asn Leu Arg Phe His Val Thr 
385                 390                 395                 400 


Phe Gly Lys Tyr Arg Trp Leu Phe Cys Gln Asp Lys Lys Cys Ala Asp 
                405                 410                 415     


Gly Ser Val Arg Pro Arg Trp Leu Gln Lys Glu Leu Asn Gly Phe Gly 
            420                 425                 430         


Arg Ile Gln Thr Val Glu Arg Lys Arg Thr Gly Leu Glu Pro Gly Trp 
        435                 440                 445             


Asp Gly Thr Gly Leu Ile Arg Lys Phe Glu Glu Val Val Thr Asp Glu 
    450                 455                 460                 


Val Gln Lys Glu Pro Tyr Ile Thr Asp Phe Arg Thr Gln Tyr Leu Phe 
465                 470                 475                 480 


Asn Arg Asp Lys Ile Gly Ile Ser Leu Ser Glu Tyr Met Pro Gly Ile 
                485                 490                 495     


Gly Asp Ile His Ser Gly Lys Glu Trp Gly Lys His Ala Gly Val Pro 
            500                 505                 510         


Asp Phe Tyr Leu Ser Val Tyr Asp Ile Pro Ala Met Leu Phe Leu Thr 
        515                 520                 525             


Trp Leu Leu Gly Lys Asn Ser Ser Ala Val Glu Lys Leu Leu Ala Asn 
    530                 535                 540                 


Cys Lys Ala Ala Tyr Met Lys Leu Phe Asp Asp Leu Ala Lys Gly Lys 
545                 550                 555                 560 


Trp Glu Gly Glu Arg Asn Val Ser Asp Tyr Cys Ala Gly Glu Gly Thr 
                565                 570                 575     


Val Arg Tyr Thr Leu Arg Trp Tyr Asp Val Pro Met Lys Ile Arg Arg 
            580                 585                 590         


Lys Met Pro Leu Leu Gly Gly Asp Arg Asp Phe Glu Glu Lys Lys Ser 
        595                 600                 605             


Phe Glu Thr Leu Ala Gln Glu Ala Leu Thr Arg Met Leu Gln Arg Thr 
    610                 615                 620                 


Glu Asn Gln Leu Glu Lys Phe Asp Arg Asp Leu Ala Ala Ala Arg Asp 
625                 630                 635                 640 


Leu Lys Ala Asn Lys Gln Gly Lys Asp Arg Phe Val Asp Ile Arg Ala 
                645                 650                 655     


Gly Ser Leu Ala Thr Phe Leu Ala Arg Asp Ile Val Arg Leu Met Pro 
            660                 665                 670         


Val Ser Asp Asn Gly Arg Asn Lys Pro Thr Gly Leu Asn Tyr Ser Ile 
        675                 680                 685             


Val Gln Lys Ala Ile Ala Thr Tyr Lys Pro Ser Glu Gly Gly Leu Asp 
    690                 695                 700                 


Thr Leu Thr Gly Val Phe Arg Asp Ala Arg Ile Ile Gly Val Lys Gly 
705                 710                 715                 720 


Gly Ser His Pro Phe Leu Glu Arg Leu Leu Val Glu Lys Lys Pro Ser 
                725                 730                 735     


Ser Val Leu Ala Leu Tyr Arg His Tyr Leu Glu Tyr Arg Lys Glu Tyr 
            740                 745                 750         


Leu Lys Lys Ala Leu Glu Asp Glu Asn Lys Ala Glu Leu Lys Asn Leu 
        755                 760                 765             


Pro Phe Leu Lys Ser Gly Arg Gln Lys Tyr Ala Val Asp Gln Ala Asp 
    770                 775                 780                 


Tyr Ala Arg Arg Leu Ala Glu Ser Tyr Arg Asn Cys Pro Ile Tyr Leu 
785                 790                 795                 800 


Pro Thr Gly Ile Phe Thr Asp Met Leu Lys Asp Gln Leu Ala Lys Ile 
                805                 810                 815     


Asp Val Met Lys Pro Val Leu Glu Asn Asp Lys Val Asn Ala Ser Tyr 
            820                 825                 830         


Leu Ile Ala Gln Tyr Phe Glu Lys Val Glu His Asp Ser Glu Gln Pro 
        835                 840                 845             


Leu Tyr Arg Leu Lys Arg Asn Tyr Arg Val Phe Asp Leu Leu Glu Phe 
    850                 855                 860                 


Thr Asp Glu Pro Lys Tyr Trp Arg Leu Asn Glu Arg Ser Asp Lys Ala 
865                 870                 875                 880 


Gly Lys Tyr Gly Leu Ala Lys Arg Asn Ile Phe Trp Asn Arg Met Gly 
                885                 890                 895     


Glu Tyr Tyr Lys Gly Leu Lys Lys Phe Tyr Lys Gly Tyr Glu Ser Lys 
            900                 905                 910         


Arg Thr Ala Val Asp Trp Arg Glu Lys Leu Lys Ile Val Glu Ala Glu 
        915                 920                 925             


His Ala Met Trp Asn Arg Leu Lys Asp Ala Ser Gly Glu Ala Arg Leu 
    930                 935                 940                 


Lys Met Lys Asp Gly Val Phe Tyr Ser Arg Leu Leu Ser Ala Arg Lys 
945                 950                 955                 960 


Glu Tyr Asp Asp Cys Glu Arg Ala Leu Arg Arg Leu Lys Val Gln Asp 
                965                 970                 975     


Ile Val Leu Phe Leu Ala Ala Arg Glu Thr Leu Ile Leu Pro Lys Asp 
            980                 985                 990         


Lys Val Phe Arg Leu Lys Asn Leu  Ser Leu Ser Glu Gly  Asn Lys Asn 
        995                 1000                 1005             


Ile Leu  Ser Ser Ala Ile Asp  Glu Phe Ser Val Asp  Val Val Trp 
    1010                 1015                 1020             


Thr Glu  Lys Glu Gly Ala Ala  Lys Val Thr His Ser  Ala Ser Ile 
    1025                 1030                 1035             


Lys Glu  Asn Asp Val Val Ile  Lys Asn Tyr Gly Arg  Met Phe Arg 
    1040                 1045                 1050             


Leu Leu  His Asp Asp Arg Val  Lys Thr Leu Leu Pro  His Ile Tyr 
    1055                 1060                 1065             


Asp Ser  Ala Leu Ser Glu Asn  Ile Thr Gly Asp Arg  Ile Thr Val 
    1070                 1075                 1080             


Lys Asp  Asn Lys Val Ile Ile  Asp Lys Ser Leu Phe  Asp Glu Asp 
    1085                 1090                 1095             


Leu Met  Asn Tyr Asp Leu Arg  Arg His Glu Ile Cys  Glu Ile Ile 
    1100                 1105                 1110             


Leu Arg  Phe Glu Ala Ala Ser  Ile Lys Arg Phe Gly  Leu Asp Gly 
    1115                 1120                 1125             


Arg Val  Asp Phe Lys Ala Ala  Leu Asp Ala Leu Thr  Gly Arg Ser 
    1130                 1135                 1140             


Leu Leu  Asn Asp Glu Asp Ala  Arg Ile Leu Ser Ala  Ile Arg Asn 
    1145                 1150                 1155             


Ala Tyr  Asn His Asn Lys Tyr  Pro Ala Lys Gly Thr  Asp Val Lys 
    1160                 1165                 1170             


Val Asn  Val Met Ala Leu Pro  Lys Leu Thr Glu Asp  Leu Leu Arg 
    1175                 1180                 1185             


Ile Phe  Ser Asp Thr Gly Asn  Asn Arg Val Arg 
    1190                 1195                 


<210>  1725
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1725

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1726
<211>  1129
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1726

Met Glu Thr Asn Gln Gln Thr His Glu Asn Arg Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Asn Asn His Ile Ala Thr Asp Phe Lys Gln Ala Thr 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ala Ala Phe Leu Cys Asn Lys Thr 
    50                  55                  60                  


Ile Lys Asn Leu Asn Trp Asn His Val His Thr Arg Ala Val Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ser Glu Ser Leu Pro Lys Asp Glu 
                85                  90                  95      


Arg Glu Asn Ser Asp Thr Glu Gly Lys Asp Phe Ala Ser Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Ser Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gln Asp Ser Arg Lys Leu Thr Val 
    130                 135                 140                 


Ser Pro Glu Leu Ala Asn Phe Leu Thr Val Asn Phe Gln Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Ala Arg Met Lys Asp Val Leu Thr Asp Ala Asp Tyr 
                165                 170                 175     


Ala Leu Val Glu Asn Leu Gln Met Val Ala Pro Asp Asn Lys Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ala Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Thr Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asn Leu Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Ser 
            260                 265                 270         


Val Ile Thr Asp Lys Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Asp Asp Glu Arg 
    290                 295                 300                 


Glu Arg Ile Leu Asp Glu Ile Asp Tyr Gln Asp Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg Tyr Ser Asn Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Asp Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Asn Tyr Thr Lys Gln Phe Ala Gly Glu 
        355                 360                 365             


Gln Ala Glu Arg Lys Val Leu Glu Asn Ala Asn Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asp Pro Glu Leu Ile Gln Gln Arg Ile Asp Lys Gln 
385                 390                 395                 400 


Gln His Thr Ala Gly Phe Asp Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Thr Lys Glu Asn Ile Ala Thr Leu Ile 
            420                 425                 430         


Ala Lys Ser Lys Ala Ser Ser Lys Val Glu His Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Gln Ala Glu Glu Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Ile Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Ser Gln Leu Pro Ala Asp Trp Asp Glu Phe Ser Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asp Ser Thr Leu Lys Tyr Leu 
        515                 520                 525             


Arg Gln Arg Lys Thr Thr Leu Asn Thr Ile Leu Ser Lys Ser Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Lys Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Thr Arg Leu Lys Ala Val Glu Lys His Lys Leu 
            580                 585                 590         


Asn Lys Ser Val Lys Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Glu Glu Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Ala Asn Ala Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Asn Asp Gly His Pro Phe Leu Gln Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Gln Ala Tyr Leu Ile 
        675                 680                 685             


Glu Lys Gly Asn Lys Met Val Pro Arg Leu Asn Pro Lys Thr Asn Lys 
    690                 695                 700                 


Thr Ser Lys Val Asp Glu Ser Trp Met Met Lys Gln Phe Tyr Val Lys 
705                 710                 715                 720 


Glu Trp Lys Glu Glu Ile Gly Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Ser Arg Ile Pro Phe Thr Ile Cys Gln Trp Asp Lys Lys 
            740                 745                 750         


Glu Ser His Asp Leu Asn Thr Trp Leu Gln His Val Thr Val Gly Lys 
        755                 760                 765             


Asn Lys Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe Asp 
    770                 775                 780                 


Glu Ala Leu Cys Asp Leu Leu Arg Glu Gln Leu Asp Thr Lys Ile Val 
785                 790                 795                 800 


Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Ile Trp Trp 
                805                 810                 815     


Lys Thr Arg Asn Asp Asp Thr Gln Gln Phe Tyr Gln Ser Glu Arg Glu 
            820                 825                 830         


Tyr Asp Ile Tyr Asn Glu Lys Val Arg Phe Lys Ile Asp Ser Ser Ala 
        835                 840                 845             


His Phe Ala Asp Tyr Tyr Lys Asn Ala Leu Ser Arg Ala Phe Thr Arg 
    850                 855                 860                 


Leu Lys Ala Glu Arg Glu Thr Ala Arg Gln Thr Asn Lys Lys Leu Pro 
865                 870                 875                 880 


Pro Leu Glu Tyr Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile Ala 
                885                 890                 895     


Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met Ala 
            900                 905                 910         


Val Leu Met Leu Glu Arg Leu Met Asp Asn Ser Pro Asn Leu Arg Leu 
        915                 920                 925             


Ser Lys Ile Glu Thr Leu Leu Asn Asp Thr Thr His Ile Ser Glu Lys 
    930                 935                 940                 


Ile Ser Ala Thr Leu Ser Phe Asp Ala Ser Gly Glu Arg Ile Ser Gly 
945                 950                 955                 960 


Lys Leu Lys Gln Thr Val Thr Lys Thr Leu Ile Ala Glu Arg Lys Gln 
                965                 970                 975     


Lys Asn Tyr Thr Glu Leu Arg Lys Tyr Arg Tyr Asp Arg Arg Leu Pro 
            980                 985                 990         


Glu Leu Phe Glu Tyr Val Gln Ala  Asp Glu Ile Pro Leu  Glu Trp Leu 
        995                 1000                 1005             


Leu Glu  Glu Leu Ser Ala Tyr  Asn Asn Ala Lys Gln  Gln Val Phe 
    1010                 1015                 1020             


Asp Thr  Val Phe Ala Leu Glu  Lys Lys Ile Val Gly  Thr Asp Pro 
    1025                 1030                 1035             


Asp Gly  Leu Lys Ser Leu Phe  Thr Asn Pro Lys Gly  Glu Pro Leu 
    1040                 1045                 1050             


Lys Gly  Asn Ile Gln His Lys  Pro Tyr Val Gln Trp  Leu Thr Asn 
    1055                 1060                 1065             


Lys Gly  Leu Ile Asn Lys Glu  Glu Lys Gln Phe Ile  Asn Met Val 
    1070                 1075                 1080             


Arg Lys  Cys Phe Ser His Asn  Gln Phe Pro Gln Arg  Lys Thr Met 
    1085                 1090                 1095             


Glu Leu  Leu Ile Pro Ala Trp  Asn Glu Lys Lys Leu  Ala Leu Gln 
    1100                 1105                 1110             


Ile Ala  Thr Val Tyr Asn Gln  Leu Ile Ala Asp Leu  Thr Asp Lys 
    1115                 1120                 1125             


Ile 
    


<210>  1727
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1727

Met Asn Thr His Gln Glu Glu Leu Gln Ser Trp Ile Thr Arg Lys Arg 
1               5                   10                  15      


Leu Pro Asp Thr Glu Met Lys Lys Tyr Trp Ala Ala Tyr Met Asn Leu 
            20                  25                  30          


Ala Arg Leu Asn Phe Phe Lys Thr Leu Met Phe Ile Ser Asn Ser Ile 
        35                  40                  45              


Gly Asp Leu Lys Pro Ala Lys Asp Asn Asn Gly Lys Gly Asn Thr Glu 
    50                  55                  60                  


Val Asn Met His Asn Met Gly Ile Leu Thr Ala Leu Leu Gly Pro Glu 
65                  70                  75                  80  


Asp Glu Glu Lys Ala Arg Leu Leu Ile Phe Lys His Phe Pro Phe Leu 
                85                  90                  95      


Arg Thr Phe Cys Ile Glu Lys Glu Leu Ser Leu Ser Lys Gln Arg Thr 
            100                 105                 110         


Ile Leu Ile Asp Met Ala Cys Ile Ile Gly Arg Tyr Arg Asn Met Tyr 
        115                 120                 125             


Ser His Ser Ile Phe Ile Ser Asp Asp Asn Glu Lys Val Leu Glu Ser 
    130                 135                 140                 


Glu Lys Arg Cys Ser Glu Tyr Leu Gln Ser Ile Leu Thr Val Ser Thr 
145                 150                 155                 160 


Arg Ile Ile Lys Glu Arg Tyr Arg Ser Asn Lys Asn Asp Ala Gln Arg 
                165                 170                 175     


Gly Met Ile Asp Asp Lys Ser Leu Lys Phe Ile Ser Glu Asn Lys Val 
            180                 185                 190         


Lys Phe Val Tyr Asp Glu Asn Gly Glu Arg Ile Thr Ala Pro Asn Lys 
        195                 200                 205             


Lys Tyr Tyr Leu Ser Thr Ile Asp Lys Asp Asn Thr His Leu Ser Tyr 
    210                 215                 220                 


Phe Gly Lys Leu Met Leu Thr Cys Ile Leu Leu Glu Lys Lys Tyr Ala 
225                 230                 235                 240 


Thr Asp Phe Leu Thr Gln Cys His Phe Leu Asp Ala Phe Asn Asp Ser 
                245                 250                 255     


Glu Val Ala Pro Lys Leu Ser Glu Arg Arg Leu Met Leu Glu Val Met 
            260                 265                 270         


Thr Ala Leu Arg Ile Arg Leu Ala Glu Lys Lys Leu Ser Asn Glu Lys 
        275                 280                 285             


Ser Glu Val Gln Ile Ser Leu Asp Ile Leu Asn Glu Leu Lys Lys Cys 
    290                 295                 300                 


Pro Phe Glu Leu Tyr Glu Leu Leu Gly Ser Glu Asp Lys Arg Leu Phe 
305                 310                 315                 320 


Thr Ile Val Ala Asp Thr Gly Glu Thr Ile Leu Leu Arg Arg His Glu 
                325                 330                 335     


Asp Arg Phe Pro Gln Leu Ala Leu Ser Trp Ile Asp Ser Ser Lys Ala 
            340                 345                 350         


Phe Asp His Leu Arg Phe Gln Val Asn Ala Gly Lys Leu Arg Tyr Leu 
        355                 360                 365             


Phe Arg Asp Asn Lys His Cys Ile Asp Gly Gln Ala Arg Met Arg Ala 
    370                 375                 380                 


Leu Glu Glu Pro Leu Asn Gly Tyr Arg Arg Leu Met Glu Phe Glu Glu 
385                 390                 395                 400 


Glu Arg Ile Gln Lys Gln Ser Gly Glu Ile Arg Ser Leu Trp Pro Gly 
                405                 410                 415     


Leu Asp Ile Leu Asn Lys Asp Glu Thr Pro Arg Asn Asp Ala Ser Val 
            420                 425                 430         


Leu Pro Tyr Ile Ser Asp Tyr Arg Val Arg Tyr Leu Phe Asp Gly Asp 
        435                 440                 445             


Asn Ile Gly Ile Ser Ile Gly Asp Phe Thr Pro Ser Ile Thr Lys Thr 
    450                 455                 460                 


Asp Glu Thr Lys Tyr Arg Val Thr Gly Lys Thr Ala Asp Cys Cys Leu 
465                 470                 475                 480 


Ser Lys Tyr Glu Leu Pro Gly Leu Leu Phe Tyr His Leu Leu Thr Leu 
                485                 490                 495     


Arg His Gly Asp Asn Lys Arg Ser Ile Lys Asn Ala Glu Asp Ile Ile 
            500                 505                 510         


Ile Asp Ala Ile Lys Arg Tyr Lys Arg Leu Phe Ser Asp Val Lys Glu 
        515                 520                 525             


Gly Ile Leu Lys Pro Ile Lys Glu Glu Asn Ala Asn Gln Leu Gly Asn 
    530                 535                 540                 


Arg Ile Trp Asn Ser Tyr Gly Ile Asp Ile Lys Asp Ile Pro Asp Lys 
545                 550                 555                 560 


Ile Ile Asp Tyr Leu Leu Val Arg Glu Cys Asn Glu Asp Glu Lys Phe 
                565                 570                 575     


Thr Ala Trp Lys Asn Gly Leu Ile Ser Glu Met Leu Gln Ser Thr Lys 
            580                 585                 590         


Asn Arg Ile Lys Arg Phe Glu Lys Asp Ser Glu Ala Val Ile Ser Ser 
        595                 600                 605             


Asp Asn Lys Pro Gly Lys Lys Asn His Val Ser Leu Lys Pro Gly Ala 
    610                 615                 620                 


Tyr Ala Ser Phe Ile Ala Asn Asp Ile Val Phe Phe Gln Glu Cys Gly 
625                 630                 635                 640 


Ala Thr Glu Lys Met Thr Gly Leu Asn Phe Asn Val Met Gln Ser Arg 
                645                 650                 655     


Leu Ala Thr Phe Thr Lys Asp Gly Ser Thr Ser Phe Asn Ile Leu Leu 
            660                 665                 670         


Gln Thr Leu Lys Asn Ala His Leu Val Ser Thr Thr Tyr Gly Lys Gly 
        675                 680                 685             


Asp His Pro Phe Leu Tyr Arg Val Ile Lys Gln Gln Pro Ser Asp Ile 
    690                 695                 700                 


Val Gln Phe Tyr Lys Ile Tyr Leu Asn Glu Lys Val Leu Tyr Leu Gln 
705                 710                 715                 720 


Ser Asp Ile Pro Asp Asn Ala Ile Phe Leu His Gly Glu Arg Lys Arg 
                725                 730                 735     


Trp Glu Asn Arg Asn Glu Gln Tyr Tyr Arg Asp Leu Ala Glu Arg Tyr 
            740                 745                 750         


Leu Gln Arg Pro Ile Gln Leu Pro Arg Gln Leu Phe Glu Ser His Ile 
        755                 760                 765             


Arg Gln Leu Leu Leu Ser Asp Cys Ile Lys Gly Glu Arg Gly Asn Asp 
    770                 775                 780                 


Leu Lys Glu Ala Ile Asn Ser Ala Ala Ser Gln Gly Arg Cys Asn Thr 
785                 790                 795                 800 


Thr Tyr Met Ile Met Glu Tyr Phe Ala Asp Tyr Leu Cys Asp Gly Thr 
                805                 810                 815     


Gln Phe Phe Tyr Gly Leu Phe Asp Gly Asp Leu Ser His Glu Tyr Asn 
            820                 825                 830         


Tyr Arg Phe Tyr Ser Leu Ile Ser Asn Asn Ile Glu Asn Ser Lys Lys 
        835                 840                 845             


Leu Val Leu Thr Leu Lys Lys Gly Asn Asn Ser Lys Glu Ser Pro Phe 
    850                 855                 860                 


Ile Ser Ala Leu Glu Arg Gly Ile His Trp Ser Lys Met Asn Pro Leu 
865                 870                 875                 880 


Met Lys Lys Gly Leu Lys Asn Asp Ser Ser Glu Gly Asp Phe Val His 
                885                 890                 895     


Ala Ala Lys Arg Ala Tyr Lys Glu Met Thr Glu Thr Glu Arg Met Phe 
            900                 905                 910         


Arg Arg Tyr Ala Val Gln Asp Glu Val Leu Phe Leu Ala Ala Lys Ile 
        915                 920                 925             


Thr Ile Arg Arg Ala Leu Gly Leu Ser Glu Gln Tyr Asn Cys Leu Leu 
    930                 935                 940                 


Gly Asp Ile Lys Pro Gln Gly Gly Ser Leu Leu Glu Gln Thr Ile Pro 
945                 950                 955                 960 


Ser Ile Thr Thr Lys His Thr Ile Asn Thr Gly Asn Lys Lys Gln Lys 
                965                 970                 975     


Pro Lys Gln Val Gln Ile Leu Gln Lys Asn Val Lys Leu Lys Asp Phe 
            980                 985                 990         


Gly Lys Val Phe Lys Leu Leu Asn  Asp Arg Arg Ile Phe  Asp Leu Leu 
        995                 1000                 1005             


Phe Asn  Lys Gly Asn Glu Ala  Val Ser Met Thr Asp  Leu Cys Glu 
    1010                 1015                 1020             


Glu Leu  Glu Arg Tyr Asp Arg  His Arg Val Asp Val  Phe Asp Ser 
    1025                 1030                 1035             


Val Leu  Lys Tyr Glu Ser Lys  Ile Thr Lys Gly Tyr  Thr Asn Lys 
    1040                 1045                 1050             


Glu Leu  Met Asn Glu Ser Gly  Gln Ile Asp Phe Lys  Ala Ile Gln 
    1055                 1060                 1065             


Ala Phe  Asp Lys Gln Asn Thr  Thr Ala Asp Lys Glu  Asp Leu Arg 
    1070                 1075                 1080             


Leu Ile  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Gln Tyr Asn 
    1085                 1090                 1095             


Asn Glu  Pro Ile Leu Phe Asp  Lys Asp Ile Pro Glu  Ile Ala Asp 
    1100                 1105                 1110             


Glu Ile  Ser Ile Ile Ala Lys  Asp Ile Glu Glu Asn  Thr Lys 
    1115                 1120                 1125         


<210>  1728
<211>  1193
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1728

Met Glu Ser Thr Val Asn Ala Lys Arg Ile Ser Tyr Asp Tyr Lys Asn 
1               5                   10                  15      


Gln Glu Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln Asn 
            20                  25                  30          


Asn Ile Glu Glu Thr Ile Glu Ala Leu Gly Ile Arg Asn Gln Val Phe 
        35                  40                  45              


Lys Lys Glu Asp Ser Asn Lys Lys Asn Lys Ser Arg Pro Ala Glu Ile 
    50                  55                  60                  


Ile Ala Lys Val Phe Gln Ile Asp Leu Lys Lys Arg Lys Thr Lys Asp 
65                  70                  75                  80  


Asp Gly Ser Gly Ile Thr Tyr Ala Gln Trp Glu Ser Asn Val Asn Phe 
                85                  90                  95      


Leu Lys Gln Tyr Leu Pro Ile Val Gln Phe Leu Asn Leu Pro Val Ser 
            100                 105                 110         


His Lys Lys Phe Asp His Leu Pro Lys Ala Lys Lys Glu Lys Ala Lys 
        115                 120                 125             


Arg Asp Tyr Phe Ile Gly Asn Phe Leu Leu Leu Ile Asp Ile Ile Gly 
    130                 135                 140                 


Ser Leu Arg His Tyr Tyr Thr His Tyr His His Lys Gln Ile Ser Ile 
145                 150                 155                 160 


Glu Pro Glu Leu Phe Thr Leu Leu Asp Glu Ile Phe Leu His Thr Cys 
                165                 170                 175     


Leu Val Val Lys Lys Arg Lys Met Lys Ser Glu Lys Thr Arg Glu Leu 
            180                 185                 190         


Leu Lys Arg Glu Leu Glu Arg Glu Val Asp Ile Leu Lys Lys Leu Lys 
        195                 200                 205             


Leu Ala Ala Leu Lys Lys Gln Lys Glu Asp Gly Val Arg Val Ser Leu 
    210                 215                 220                 


Asp Asp Glu His Val Glu Arg Ala Val Leu Asn Glu Ser Phe Asn Tyr 
225                 230                 235                 240 


Leu Leu Ala Lys Arg Asp Asn Val Tyr Lys Val Gln Pro Thr His Cys 
                245                 250                 255     


Ser Arg Gly Glu Asp Gly Thr Pro Phe Ser Arg Ser Gly Leu Val Phe 
            260                 265                 270         


Leu Val Ser Met Phe Leu Thr Lys Lys Gln Gly Glu Asp Phe Arg Ser 
        275                 280                 285             


Arg Ile Lys Gly Phe Lys Glu Lys Ile Val Lys Arg Glu Glu Asn Ala 
    290                 295                 300                 


Ile Ser Pro Thr Asn Asn Ser Leu Arg Phe Met Ala Thr His Trp Val 
305                 310                 315                 320 


Phe Ser Tyr Trp Ser Tyr Lys Gly Phe Lys Ala Lys Leu Asn Thr Thr 
                325                 330                 335     


Phe Ser Lys Glu Val Leu Glu Leu Lys Gly Ile Glu His Arg Leu Asn 
            340                 345                 350         


Thr Thr Val Ile Ser Lys Glu Ala Leu Leu Ala Gln Ile Val Asp Glu 
        355                 360                 365             


Leu Ser Lys Val Pro Asp Glu Val Tyr Glu Val Leu Ser Leu Asp Lys 
    370                 375                 380                 


Arg Asn Glu Phe Leu Glu Asp Val Asn Glu Tyr Ile Arg Glu Thr Arg 
385                 390                 395                 400 


Glu Val Glu Thr Leu Asp Lys Ser Ile Val Glu His Ser Val Ile Arg 
                405                 410                 415     


Lys Arg Tyr Glu Ser Lys Phe Gly Tyr Leu Ala Leu Arg Tyr Leu Asp 
            420                 425                 430         


Glu Phe Val Asp Phe Pro Ser Leu Arg Phe Gln Val Arg Leu Gly Asn 
        435                 440                 445             


Tyr Val His Asp Ser Arg Thr Lys Val Ile Glu Gly Thr Lys Leu Val 
    450                 455                 460                 


Thr Glu Arg Gln Ile Lys Glu Pro Ile Asn Val Phe Gly Lys Leu Ser 
465                 470                 475                 480 


Lys Val Lys Glu Leu Lys Thr Gln Phe Phe Leu Ser Ser Asp Asp Glu 
                485                 490                 495     


Glu Asn Ser Met Glu Ile Phe Pro Asn Pro Ser Tyr Cys Phe Val Glu 
            500                 505                 510         


Asn Asn Ile Pro Ile Ile Phe Ser Val Glu Gly Asn Val Lys Ala Asn 
        515                 520                 525             


Ser Ile Tyr Asn Lys Ile Lys Leu Lys Ile Arg Thr Gln Arg Asn Lys 
    530                 535                 540                 


Asp Glu Lys Arg Val Asp Arg Ser Gly Arg Lys Phe Pro Lys Ser Arg 
545                 550                 555                 560 


Ile Phe Ser Ile Val Asn Ser Lys Trp Asp Lys Ser Glu Ser Lys Lys 
                565                 570                 575     


Val Lys Leu Ala Glu Pro Met Ala Leu Leu Ser Phe Asn Glu Leu Pro 
            580                 585                 590         


Ser Leu Leu Tyr Glu Leu Leu His Lys Lys Lys Thr Pro Gln Ala Ile 
        595                 600                 605             


Glu Asp Ala Ile Val Glu Lys Tyr Val Glu Gln Phe Glu Ala Ile Glu 
    610                 615                 620                 


Asn Phe Asp Ser Gln Ser Thr Val Gln Lys Ser Arg Ile Pro Lys Lys 
625                 630                 635                 640 


Met Lys Lys Ser Asp Lys Ile Gly Lys Leu Asp Tyr Glu Lys Leu Val 
                645                 650                 655     


Lys Asp Ile Asp Arg Ser Leu Ala Glu Thr Lys Glu Lys Arg Lys Leu 
            660                 665                 670         


Leu Leu Gln Lys Gln Lys Asp Ala Lys Glu Asn Asn Lys Gln Thr Leu 
        675                 680                 685             


Ser Ser Ser Glu Leu Gly Gln Glu Ala Val Trp Leu Ser Asp Asp Ile 
    690                 695                 700                 


Lys Arg Leu Met Pro Arg Ser Ser Arg Lys Glu Trp Lys Gly Arg His 
705                 710                 715                 720 


His Ser His Leu Gln Tyr Thr Leu Ala Phe Tyr Asp Val Arg Lys Lys 
                725                 730                 735     


Glu Ala Leu Ala Leu Leu Glu Asn Phe Trp Asp Met Asp Lys Asp Pro 
            740                 745                 750         


Tyr Trp Gly Glu Lys Leu Lys Asn Glu Phe Asn Ala Asn Asn Thr Phe 
        755                 760                 765             


Glu Tyr Phe Tyr Phe Ser Tyr Leu Asn Leu Arg Glu Gly Ile Leu Ser 
    770                 775                 780                 


Thr Phe Leu Asp Gln Ile Glu Glu Tyr Lys Asp Gln Pro Gly Asn Leu 
785                 790                 795                 800 


Lys Lys Ala Leu Lys Asp Ile Gly Ile Val Phe Gln Met Arg Lys Tyr 
                805                 810                 815     


Arg Ile Lys Pro Leu Glu Asp Gln Lys Thr Ala Leu Leu Ala Lys Pro 
            820                 825                 830         


Ile Leu Leu Pro Arg Gly Ile Phe Asp Pro Lys Pro Thr Phe Ile Lys 
        835                 840                 845             


Lys Lys Arg Met Asp Glu Phe Pro Asp Glu Phe Ala Glu Trp Tyr Thr 
    850                 855                 860                 


Tyr Ala Asn Ala Pro Glu Arg Gln Phe Gln Arg Phe Tyr Ala Met Glu 
865                 870                 875                 880 


Arg Asp Tyr Gln Glu Leu Trp Lys Thr Glu Lys Asp Thr Asp Pro Asp 
                885                 890                 895     


Phe Lys Gln Asn Lys Lys Gly Ile Ser Glu Glu Gln Gln Ile Ala Leu 
            900                 905                 910         


Phe Lys Met Lys Gln Asp Leu Lys Ile Lys Lys Ile Lys Thr Gln Asp 
        915                 920                 925             


Leu Phe Leu Lys Leu Ile Ala Glu Gln Leu Tyr Leu Asp Val Phe Gly 
    930                 935                 940                 


His Lys Ala Thr Phe Ser Leu Ser Asp Met Tyr Gln Thr Lys Glu Glu 
945                 950                 955                 960 


Arg Arg Glu Ile Glu Arg Leu Ser Ala Lys Gln Ser Asn Arg Ala Gln 
                965                 970                 975     


Gly Asp Lys Ser Asp Asn Ile Val Ser Glu Asn Tyr Ile Trp Asn Lys 
            980                 985                 990         


Thr Val Gly Phe Lys Asp Gln Gln  Leu Glu Glu Pro Cys  Val Lys Leu 
        995                 1000                 1005             


Lys Asp  Ile Gly Lys Ile Arg  Arg Phe Val Asn Asn  Glu Lys Val 
    1010                 1015                 1020             


Gln Lys  Leu Phe Ala Tyr Asn  Leu Asp Arg Ile Trp  Thr Lys Arg 
    1025                 1030                 1035             


Glu Leu  Glu Asp Glu Leu Glu  Met Lys Pro Ser Ser  Tyr Glu Val 
    1040                 1045                 1050             


Ile Arg  Arg Glu Lys Leu Leu  Lys Glu Val Gln Asn  Leu Glu Lys 
    1055                 1060                 1065             


Tyr Ile  Leu Lys Gln Tyr Gly  Phe Asp Asn Glu Asn  His Pro Ser 
    1070                 1075                 1080             


Ile Phe  Glu Arg Asp Gly Asn  Pro Asn Phe Asn Glu  Tyr Val Val 
    1085                 1090                 1095             


Gln Gly  Ile Leu Lys Lys Lys  Asn Leu Val Ser Glu  Asp Glu Cys 
    1100                 1105                 1110             


Asp Trp  Phe Ser Lys Gln Lys  Ile Glu Lys Ile Lys  Leu Asp Thr 
    1115                 1120                 1125             


Leu Arg  Gln Lys Ser Asp Ile  Leu Ile Lys Ala Tyr  Ile Leu Ile 
    1130                 1135                 1140             


Leu Ile  Arg Asn Thr Phe Ala  His Asn Gln Leu Pro  Asp Lys Glu 
    1145                 1150                 1155             


Cys Val  Asp Leu Met Gln Glu  Phe Cys Gln Lys Asp  Pro Gly Ile 
    1160                 1165                 1170             


Ser Tyr  Ser Glu Tyr Phe Leu  Tyr Val Phe Gln Gln  Ile Ala Lys 
    1175                 1180                 1185             


Glu Phe  Thr Asn Ala 
    1190             


<210>  1729
<211>  1090
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1729

Met Asn Ile Pro Ala Leu Val Glu Asn Gln Lys Lys Tyr Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Val Met Ala Met Leu Asn Ala Gln Thr Val Leu Asp His Ile 
            20                  25                  30          


Gln Lys Val Ala Asp Ile Glu Gly Glu Gln Asn Glu Asn Asn Glu Asn 
        35                  40                  45              


Leu Trp Phe His Pro Val Met Ser His Leu Tyr Asn Ala Lys Asn Gly 
    50                  55                  60                  


Tyr Asp Lys Gln Pro Glu Lys Thr Met Phe Ile Ile Glu Arg Leu Gln 
65                  70                  75                  80  


Ser Tyr Phe Pro Phe Leu Lys Ile Met Ala Glu Asn Gln Arg Glu Tyr 
                85                  90                  95      


Ser Asn Gly Lys Tyr Lys Gln Asn Arg Val Glu Val Asn Ser Asn Asp 
            100                 105                 110         


Ile Phe Glu Val Leu Lys Arg Ala Phe Gly Val Leu Lys Met Tyr Arg 
        115                 120                 125             


Asp Leu Thr Asn His Tyr Lys Thr Tyr Glu Glu Lys Leu Asn Asp Gly 
    130                 135                 140                 


Cys Glu Phe Leu Thr Ser Thr Glu Gln Pro Leu Ser Gly Met Ile Asn 
145                 150                 155                 160 


Asn Tyr Tyr Thr Val Ala Leu Arg Asn Thr Lys Glu Arg Tyr Gly Tyr 
                165                 170                 175     


Lys Thr Glu Asp Leu Ala Phe Ile Gln Asp Asn Arg Asn Lys Ser Thr 
            180                 185                 190         


Lys Asp Ala Tyr Gly Lys Arg Lys Ser Gln Val Asn Thr Gly Phe Phe 
        195                 200                 205             


Leu Ser Leu Gln Asp Tyr Asn Gly Asp Thr Thr Lys Lys Leu His Leu 
    210                 215                 220                 


Ser Gly Val Gly Ile Ala Leu Leu Ile Cys Leu Phe Leu Asp Lys Gln 
225                 230                 235                 240 


Tyr Ile Asn Leu Phe Leu Ser Arg Leu Pro Ile Phe Ser Ser Tyr Asn 
                245                 250                 255     


Ala Lys Ser Glu Glu Arg Arg Ile Ile Ile Arg Ser Phe Gly Ile Asn 
            260                 265                 270         


Ser Ile Lys Leu Pro Lys Asp Arg Ile His Ser Glu Lys Ser Asn Lys 
        275                 280                 285             


Ser Val Ala Met Asp Met Leu Asn Glu Val Lys Arg Cys Pro Asp Glu 
    290                 295                 300                 


Leu Phe Thr Thr Leu Ser Ala Glu Lys Gln Ser Arg Phe Arg Ile Ile 
305                 310                 315                 320 


Ser Asp Asp His Asn Glu Val Leu Met Lys Arg Ser Thr Asp Arg Phe 
                325                 330                 335     


Val Pro Leu Leu Leu Gln Tyr Ile Asp Tyr Gly Lys Leu Phe Asp His 
            340                 345                 350         


Ile Arg Phe His Val Asn Met Gly Lys Leu Arg Tyr Leu Leu Lys Ala 
        355                 360                 365             


Asp Lys Thr Cys Ile Asp Gly Gln Thr Arg Val Arg Val Ile Glu Gln 
    370                 375                 380                 


Pro Leu Asn Gly Phe Gly Arg Leu Glu Glu Ala Glu Ala Met Arg Lys 
385                 390                 395                 400 


Gln Glu Asn Gly Thr Phe Gly Asn Ser Gly Ile Arg Ile Arg Asp Phe 
                405                 410                 415     


Glu Asn Val Lys Arg Asp Asp Ala Asn Pro Ala Asn Tyr Pro Tyr Ile 
            420                 425                 430         


Val Asp Thr Tyr Thr His Tyr Ile Leu Glu Asn Asn Lys Val Glu Met 
        435                 440                 445             


Phe Ile Ser Asp Lys Gly Ser Ser Ala Pro Leu Leu Pro Val Ile Glu 
    450                 455                 460                 


Asp Asp Arg Tyr Val Val Lys Thr Ile Pro Ser Cys Arg Met Ser Thr 
465                 470                 475                 480 


Leu Glu Ile Pro Ala Met Ala Phe His Met Phe Leu Phe Gly Ser Lys 
                485                 490                 495     


Lys Thr Glu Lys Leu Ile Val Asp Val His Asn Arg Tyr Lys Arg Leu 
            500                 505                 510         


Phe Gln Ala Met Gln Lys Glu Glu Val Thr Ala Gln Asn Ile Ala Ser 
        515                 520                 525             


Phe Gly Ile Ala Glu Ser Asp Leu Pro Gln Lys Ile Leu Asp Leu Ile 
    530                 535                 540                 


Ser Gly Asn Ala His Gly Lys Asp Val Asp Ala Phe Ile Arg Leu Thr 
545                 550                 555                 560 


Val Asp Asp Met Leu Thr Asp Thr Glu Arg Arg Ile Lys Arg Phe Lys 
                565                 570                 575     


Asp Asp Arg Lys Ser Ile Arg Ser Ala Asp Asn Lys Met Gly Lys Arg 
            580                 585                 590         


Gly Phe Lys Gln Ile Ser Thr Gly Arg Leu Ala Asp Phe Leu Ala Lys 
        595                 600                 605             


Asp Ile Val Leu Phe Gln Pro Ser Val Asn Asp Gly Glu Asn Lys Ile 
    610                 615                 620                 


Thr Gly Leu Asn Tyr Arg Ile Met Gln Ser Ala Ile Ala Val Tyr Asp 
625                 630                 635                 640 


Ser Gly Asp Asp Tyr Glu Ala Lys Gln Gln Phe Lys Leu Met Phe Glu 
                645                 650                 655     


Lys Ala Arg Leu Ile Gly Lys Gly Thr Thr Glu Pro His Pro Phe Leu 
            660                 665                 670         


Tyr Lys Val Phe Ala Arg Ser Ile Pro Ala Asn Ala Val Glu Phe Tyr 
        675                 680                 685             


Glu Arg Tyr Leu Ile Glu Arg Lys Phe Tyr Leu Ile Gly Leu Ser Asn 
    690                 695                 700                 


Glu Ile Lys Lys Gly Asn Lys Val Asp Val Pro Phe Ile Arg Arg Asp 
705                 710                 715                 720 


Gln Asn Lys Trp Lys Thr Pro Ala Met Lys Thr Leu Gly Arg Ile Tyr 
                725                 730                 735     


Ser Glu Asp Leu Pro Val Glu Leu Pro Arg Gln Met Phe Asp Asn Glu 
            740                 745                 750         


Ile Lys Ser His Leu Lys Ser Leu Pro Gln Met Glu Gly Ile Asp Phe 
        755                 760                 765             


Asn Asn Ala Asn Ile Thr Tyr Leu Ile Ala Glu Tyr Met Lys Arg Val 
    770                 775                 780                 


Leu Asp Asp Asp Phe Gln Thr Phe Tyr Gln Trp Asn Arg Asn Tyr His 
785                 790                 795                 800 


Tyr Met Asp Met Leu Lys Gly Glu Tyr Asp Arg Lys Gly Ser Leu Gln 
                805                 810                 815     


His Cys Phe Thr Ser Val Glu Glu Arg Glu Cys Leu Trp Lys Glu Arg 
            820                 825                 830         


Val Thr Arg Thr Glu Gln Tyr Arg Arg Leu Ala Ser Asn Lys Ile Arg 
        835                 840                 845             


Ser Asn Arg Gln Met Arg Asn Ala Ser Ser Glu Glu Ile Glu Thr Ile 
    850                 855                 860                 


Leu Asp Lys Arg Leu Ser Asn Ser Arg Asn Glu Tyr Gln Lys Ser Glu 
865                 870                 875                 880 


Lys Val Ile Arg Arg Tyr Arg Val Gln Asp Ala Leu Leu Phe Leu Leu 
                885                 890                 895     


Ala Lys Lys Thr Leu Thr Glu Leu Ala Asp Phe Asp Gly Glu Arg Phe 
            900                 905                 910         


Lys Leu Lys Glu Ile Met Pro Asp Ala Glu Lys Gly Ile Leu Ser Glu 
        915                 920                 925             


Ile Met Pro Met Ser Phe Thr Phe Glu Lys Gly Gly Lys Ile Tyr Thr 
    930                 935                 940                 


Ile Thr Ser Gly Gly Met Lys Leu Lys Asn Tyr Gly Asp Phe Phe Val 
945                 950                 955                 960 


Leu Ala Ser Asp Lys Arg Ile Gly Asn Leu Leu Glu Leu Val Gly Ser 
                965                 970                 975     


Asn Thr Val Ser Lys Glu Asp Ile Met Glu Glu Phe Lys Lys Tyr Asp 
            980                 985                 990         


Gln Cys Arg Pro Glu Ile Ser Ser  Ile Val Phe Asn Leu  Glu Lys Trp 
        995                 1000                 1005             


Ala Phe  Asp Thr Tyr Pro Glu  Leu Pro Ala Arg Val  Asp Arg Lys 
    1010                 1015                 1020             


Glu Lys  Val Asp Phe Lys Ser  Ile Leu Lys Ile Leu  Leu Asn Asn 
    1025                 1030                 1035             


Lys Asn  Ile Asn Lys Glu Gln  Ser Asp Ile Leu Arg  Asn Ile Arg 
    1040                 1045                 1050             


Asn Ala  Phe Asp His Asn Asn  Tyr Pro Asp Lys Gly  Ile Val Glu 
    1055                 1060                 1065             


Ile Arg  Ala Leu Pro Glu Ile  Ala Met Ser Ile Lys  Lys Ala Phe 
    1070                 1075                 1080             


Gly Glu  Tyr Ala Ile Met Lys  
    1085                 1090 


<210>  1730
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1730

Leu Gln Lys Gln Asp Lys Leu Phe Val Asp Arg Lys Lys Asn Ala Ile 
1               5                   10                  15      


Phe Ala Phe Pro Lys Tyr Ile Thr Ile Met Glu Asn Gln Glu Lys Pro 
            20                  25                  30          


Glu Pro Ile Tyr Tyr Glu Leu Thr Asp Lys His Phe Trp Ala Ala Phe 
        35                  40                  45              


Leu Asn Leu Ala Arg His Asn Val Tyr Thr Thr Ile Asn His Ile Asn 
    50                  55                  60                  


Arg Arg Leu Glu Ile Ala Glu Leu Lys Asp Asp Gly Tyr Met Met Asp 
65                  70                  75                  80  


Ile Lys Gly Ser Trp Asn Glu Gln Ala Lys Lys Leu Asp Lys Lys Val 
                85                  90                  95      


Arg Leu Arg Asp Leu Ile Met Lys His Phe Pro Phe Leu Glu Ala Ala 
            100                 105                 110         


Ala Tyr Glu Ile Thr Asn Ser Lys Ser Pro Asn Asn Lys Glu Gln Arg 
        115                 120                 125             


Glu Lys Glu Gln Ser Glu Ala Leu Ser Leu Asn Asn Leu Lys Asn Val 
    130                 135                 140                 


Leu Phe Ile Phe Leu Glu Lys Leu Gln Val Leu Arg Asn Tyr Tyr Ser 
145                 150                 155                 160 


His Tyr Lys Tyr Ser Glu Glu Ser Pro Lys Pro Ile Phe Glu Thr Ser 
                165                 170                 175     


Leu Leu Lys Asn Met Tyr Lys Val Phe Asp Ala Asn Val Arg Leu Val 
            180                 185                 190         


Lys Arg Asp Tyr Met His His Glu Asn Ile Asp Met Gln Arg Asp Phe 
        195                 200                 205             


Thr His Leu Asn Arg Lys Lys Gln Val Gly Arg Thr Lys Asn Ile Ile 
    210                 215                 220                 


Asp Ser Pro Asn Phe His Tyr His Phe Ala Asp Lys Glu Gly Asn Met 
225                 230                 235                 240 


Thr Ile Ala Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Asp Lys Lys 
                245                 250                 255     


Asp Ala Ile Trp Met Gln Lys Lys Leu Lys Gly Phe Lys Asp Gly Arg 
            260                 265                 270         


Asn Leu Arg Glu Gln Met Thr Asn Glu Val Phe Cys Arg Ser Arg Ile 
        275                 280                 285             


Ser Leu Pro Lys Leu Lys Leu Glu Asn Val Gln Thr Lys Asp Trp Met 
    290                 295                 300                 


Gln Leu Asp Met Leu Asn Glu Leu Val Arg Cys Pro Lys Ser Leu Tyr 
305                 310                 315                 320 


Glu Arg Leu Arg Glu Lys Asp Arg Glu Ser Phe Lys Val Pro Phe Asp 
                325                 330                 335     


Ile Phe Ser Asp Asp Tyr Asp Ala Glu Glu Glu Pro Phe Lys Asn Thr 
            340                 345                 350         


Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe 
        355                 360                 365             


Asp Leu Asn Glu Ile Phe Glu Gln Leu Arg Phe Gln Ile Asp Leu Gly 
    370                 375                 380                 


Thr Tyr His Phe Ser Ile Tyr Asn Lys Arg Ile Gly Asp Glu Asp Glu 
385                 390                 395                 400 


Val Arg His Leu Thr His His Leu Tyr Gly Phe Ala Arg Ile Gln Asp 
                405                 410                 415     


Phe Ala Gln Gln Asn Gln Pro Glu Val Trp Arg Lys Leu Val Lys Asp 
            420                 425                 430         


Leu Asp Tyr Phe Glu Ala Ser Gln Glu Pro Tyr Ile Pro Lys Thr Ala 
        435                 440                 445             


Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Lys Phe Cys Ser 
    450                 455                 460                 


Thr His Asn Asn Leu Phe Pro Ser Leu Lys Thr Glu Lys Thr Cys Asn 
465                 470                 475                 480 


Gly Arg Ser Lys Phe Asn Leu Gly Thr Gln Phe Thr Ala Glu Ala Phe 
                485                 490                 495     


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu 
            500                 505                 510         


Thr Lys Asp Tyr Ser Arg Lys Glu Ser Ala Asp Lys Val Glu Gly Ile 
        515                 520                 525             


Ile Arg Lys Glu Ile Ser Asn Ile Tyr Ala Ile Tyr Asp Ala Phe Ala 
    530                 535                 540                 


Asn Gly Glu Ile Asn Ser Ile Ala Asp Leu Thr Cys Arg Leu Gln Lys 
545                 550                 555                 560 


Thr Asn Ile Leu Gln Gly His Leu Pro Lys Gln Met Ile Ser Ile Leu 
                565                 570                 575     


Glu Gly Arg Gln Lys Asp Met Glu Lys Glu Ala Glu Arg Lys Ile Gly 
            580                 585                 590         


Glu Met Ile Asp Asp Thr Gln Arg Arg Leu Asp Leu Leu Cys Lys Gln 
        595                 600                 605             


Thr Asn Gln Lys Ile Arg Ile Gly Lys Arg Asn Ala Gly Leu Leu Lys 
    610                 615                 620                 


Ser Gly Lys Ile Ala Asp Trp Leu Val Asn Asp Met Met Arg Phe Gln 
625                 630                 635                 640 


Pro Val Gln Lys Asp Gln Asn Asn Ile Pro Ile Asn Asn Ser Lys Ala 
                645                 650                 655     


Asn Ser Thr Glu Tyr Arg Met Leu Gln Arg Ala Leu Ala Leu Phe Gly 
            660                 665                 670         


Ser Glu Asn Phe Arg Leu Lys Ala Tyr Phe Asn Gln Met Asn Leu Val 
        675                 680                 685             


Gly Asn Asp Asn Pro His Pro Phe Leu Ala Glu Thr Gln Trp Glu His 
    690                 695                 700                 


Gln Thr Asn Ile Leu Ser Phe Tyr Arg Asn Tyr Leu Glu Ala Arg Lys 
705                 710                 715                 720 


Lys Tyr Leu Lys Gly Leu Lys Pro Gln Asn Trp Lys Gln Tyr Gln His 
                725                 730                 735     


Phe Leu Ile Leu Lys Val Gln Lys Thr Asn Arg Asn Thr Leu Val Thr 
            740                 745                 750         


Gly Trp Lys Asn Ser Phe Asn Leu Pro Arg Gly Ile Phe Thr Gln Pro 
        755                 760                 765             


Ile Arg Glu Trp Phe Glu Lys His Asn Asn Ser Lys Arg Ile Tyr Asp 
    770                 775                 780                 


Gln Ile Leu Ser Phe Asp Arg Val Gly Phe Val Ala Lys Ala Ile Pro 
785                 790                 795                 800 


Leu Tyr Phe Ala Glu Glu Tyr Lys Asp Asn Val Gln Pro Phe Tyr Asp 
                805                 810                 815     


Tyr Pro Phe Asn Ile Gly Asn Lys Leu Lys Pro Gln Lys Gly Gln Phe 
            820                 825                 830         


Leu Asp Lys Lys Glu Arg Val Glu Leu Trp Gln Lys Asn Lys Glu Leu 
        835                 840                 845             


Phe Lys Asn Tyr Pro Ser Glu Lys Lys Lys Thr Asp Leu Ala Tyr Leu 
    850                 855                 860                 


Asp Phe Leu Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys 
865                 870                 875                 880 


Asn Gln Asp Ile Val Thr Trp Leu Met Phe Lys Glu Leu Phe Asn Met 
                885                 890                 895     


Ala Thr Val Glu Gly Leu Lys Ile Gly Glu Ile His Leu Arg Asp Ile 
            900                 905                 910         


Asp Thr Asn Thr Ala Asn Glu Glu Ser Asn Asn Ile Leu Asn Arg Ile 
        915                 920                 925             


Met Pro Met Lys Leu Pro Val Lys Thr Tyr Glu Thr Asp Asn Lys Gly 
    930                 935                 940                 


Asn Ile Leu Lys Glu Arg Pro Leu Ala Thr Phe Tyr Ile Glu Glu Thr 
945                 950                 955                 960 


Glu Thr Lys Val Leu Lys Gln Gly Asn Phe Lys Val Leu Ala Lys Asp 
                965                 970                 975     


Arg Arg Leu Asn Gly Leu Leu Ser Phe Ala Glu Thr Thr Asp Ile Asp 
            980                 985                 990         


Leu Glu Lys Asn Pro Ile Thr Lys  Leu Ser Val Asp His  Glu Leu Ile 
        995                 1000                 1005             


Lys Tyr  Gln Thr Thr Arg Ile  Ser Ile Phe Glu Met  Thr Leu Gly 
    1010                 1015                 1020             


Leu Glu  Lys Lys Leu Ile Asn  Lys Tyr Pro Thr Leu  Pro Thr Asp 
    1025                 1030                 1035             


Ser Phe  Arg Asn Met Leu Glu  Arg Trp Leu Gln Cys  Lys Ala Asn 
    1040                 1045                 1050             


Arg Pro  Glu Leu Lys Asn Tyr  Val Asn Ser Leu Ile  Ala Val Arg 
    1055                 1060                 1065             


Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met Tyr Asp  Ala Thr Leu 
    1070                 1075                 1080             


Phe Ala  Glu Val Lys Lys Phe  Thr Leu Phe Pro Ser  Val Asp Thr 
    1085                 1090                 1095             


Lys Lys  Ile Glu Leu Asn Ile  Ala Pro Gln Leu Leu  Glu Ile Val 
    1100                 1105                 1110             


Gly Lys  Ala Ile Lys Glu Ile  Glu Lys Ser Glu Asn  Lys Asn 
    1115                 1120                 1125         


<210>  1731
<211>  1361
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1731

Met Gly Lys Asn Tyr Tyr Ser Lys Asn Gly Asn Ala Ser Asn Lys Asn 
1               5                   10                  15      


Ala Lys Val Gln Lys Ala Pro Arg Leu Thr Asn Glu Pro Phe Thr Ile 
            20                  25                  30          


Arg Glu Asp Asp Lys Lys Ile Tyr Gly Ala Tyr Phe Asn Met Ala Leu 
        35                  40                  45              


Asp Asn Phe Phe Lys Thr Ile Ala Tyr Ile Phe Asn Val Leu Asp Ile 
    50                  55                  60                  


Lys Gln Phe Val Arg Thr Lys Tyr Asp Gly Glu Tyr Val Glu Val Pro 
65                  70                  75                  80  


Met Phe Ser Glu Glu Ser Leu His Ile Ile Leu Lys Tyr Tyr Ser Lys 
                85                  90                  95      


Phe Phe Gly Gly Thr Leu Lys Ser Asp Lys Leu Lys Lys Asn Val Lys 
            100                 105                 110         


Lys Leu Ser Arg Leu Ser Ser Lys Asn Glu Glu Gln Glu Gln Lys Tyr 
        115                 120                 125             


Glu Glu Asp Leu Asp Glu Leu Ile Gln Ser Leu Gln Leu Thr Asn Glu 
    130                 135                 140                 


Gln Gln Gln Lys Phe Gln Gln Met Leu Phe Arg His Phe Pro Phe Leu 
145                 150                 155                 160 


Gly Pro Ile Met Ala Asp Tyr Ala Ser Tyr Ser Ile Tyr Gln Gln Ala 
                165                 170                 175     


Ser Lys Asp Val Ser Asp Lys Glu Glu Ile Lys Lys Arg Lys Lys Glu 
            180                 185                 190         


Ile Met Asn Ser Tyr Asp Ser Leu Arg Gly Val Thr Leu Ser Gln Cys 
        195                 200                 205             


Leu Glu Glu Leu Ser Lys Met Ala Glu Cys Leu Thr Ala Cys Arg Asn 
    210                 215                 220                 


Lys Tyr Thr His Phe Lys Pro Tyr Asn Ser Leu Glu Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Leu Glu Leu Gln Phe Thr Ile Ala Lys Lys Leu Asp Lys Leu Leu 
                245                 250                 255     


Ala Ala Ser Arg Arg Leu Thr Lys Gln Asn Ile Ala Ile Thr Thr Glu 
            260                 265                 270         


Glu Met Glu Phe Ile Thr Gly Ile Asp His Tyr Glu Asn Val Asn Lys 
        275                 280                 285             


Gln Phe Ile Glu Arg Glu Asp Phe Tyr Phe Asn Pro Lys Gly Lys Gly 
    290                 295                 300                 


Met Ala Val Ile Glu Ser Asn Asp Ala Asn Gly Ala His Gln Gln Ser 
305                 310                 315                 320 


Ser Ser Thr Tyr Asp Ala Phe Ser Pro Phe Gly Ile Ala Tyr Phe Cys 
                325                 330                 335     


Ile Leu Phe Leu Ser Lys Thr Tyr Ala Arg Leu Phe Ile Asp Glu Ile 
            340                 345                 350         


Asn Leu Phe Ala Gly Ser Pro Phe Asn Asp Ser Glu Asn Ala Ile Met 
        355                 360                 365             


Arg Glu Ile Met Ser Leu Tyr Arg Val Arg Thr Pro Arg Gly Lys Arg 
    370                 375                 380                 


Leu Asp Ser Lys Ala Thr Asp Ser Thr Leu Gly Met Asp Ile Leu Asn 
385                 390                 395                 400 


Glu Leu Arg Lys Cys Pro Met Glu Leu Tyr Glu Thr Leu Ser Gln Glu 
                405                 410                 415     


Gly Arg Arg Phe Phe Glu Asp Glu Val Lys Arg Gln Asn Asp His Thr 
            420                 425                 430         


Pro Glu Val Val Lys Arg Leu Arg Ser Thr Asp Arg Phe Pro Tyr Leu 
        435                 440                 445             


Ala Met Arg Tyr Ile Asp Glu Thr Arg Met Phe Asp Asp Ile Arg Phe 
    450                 455                 460                 


Gln Val Arg Leu Gly Ser Tyr Arg Phe Arg Phe Tyr Lys Lys Ile Asp 
465                 470                 475                 480 


Cys Val Asp Gly Val Asp Arg Val Arg Arg Ile Gln Lys Glu Ile Asn 
                485                 490                 495     


Gly Phe Gly Arg Leu Gln Asp Ile Glu Asn Glu Arg Lys Thr Asn Trp 
            500                 505                 510         


Glu Ala Gln Met Gln Asp Ala Asn Tyr Lys Ser Val Lys Leu Glu His 
        515                 520                 525             


Glu Asp Leu Tyr Leu Asp Leu Arg Gln Phe Pro Lys Asp Thr Glu Ser 
    530                 535                 540                 


Gln Gln Pro Tyr Ile Thr Asp Arg Arg Ala Glu Tyr Asn Ile His Asn 
545                 550                 555                 560 


Asn Arg Ile Gly Leu Tyr Trp Asn Arg Glu Thr Asp Thr Pro Glu Tyr 
                565                 570                 575     


Leu Asp Asp Ala Lys Cys Phe Leu Pro Lys Leu Glu Thr Thr Gly Asp 
            580                 585                 590         


Ala Gly Lys Arg Lys Ala Gln Ile Ile Gln Pro Ala Pro Leu Cys Thr 
        595                 600                 605             


Leu Ser Val Arg Glu Leu Pro Ala Met Leu Phe Tyr Gln Trp Leu Cys 
    610                 615                 620                 


Asp Asn Tyr Lys Thr Asp Met Pro His Asp Ser Ala Glu Leu Leu Ile 
625                 630                 635                 640 


Lys Lys Lys Tyr Asp Ser Leu Val Arg Leu Phe Thr Ala Ile Lys Asn 
                645                 650                 655     


Gly Thr Phe Ser Tyr Lys Thr Thr Glu Glu Ala Thr Val Lys Tyr Leu 
            660                 665                 670         


Lys Asn Lys Phe Lys Leu Thr Leu Ala Asp Val Pro Gln Lys Leu Arg 
        675                 680                 685             


Met Tyr Ile Val Gly Lys Glu Thr His Pro Leu Gln Arg Leu Ile Glu 
    690                 695                 700                 


Val Thr Phe Asp Gly Tyr Glu Asp Asn Ser Gly Lys His Lys Gly Lys 
705                 710                 715                 720 


Leu Glu Gln Arg Arg Glu Lys Ile Glu Arg Arg Leu Glu Lys Tyr Lys 
                725                 730                 735     


Asp Asp Arg Lys Lys Ile Gly Asp Lys Thr Asn Thr Tyr Gly Lys Lys 
            740                 745                 750         


Ser Phe Val Asp Val Arg Leu Gly Ser Leu Ala Lys Phe Leu Ala Arg 
        755                 760                 765             


Asp Ile Ile Glu Trp Gln Pro Ser Asn Asn Glu Gly Arg Asp Lys Met 
    770                 775                 780                 


Thr Gly Met Asn Tyr Thr Val Met Gln Ser Phe Leu Ala Ser Tyr Gly 
785                 790                 795                 800 


Thr Lys Gln Ala Glu Gln Glu Gly Lys Thr Arg Ile Ser Ile Thr Gln 
                805                 810                 815     


Met Phe Thr Asn Ala Lys Leu Leu Asn Gly Pro Thr Ala His Pro Phe 
            820                 825                 830         


Leu Gln Asn Val Leu Asn Lys Gly Ala Lys Asn Ile Glu Lys Phe Tyr 
        835                 840                 845             


Leu Asp Tyr Leu Gln Glu Glu Ile Asp His Ile Lys Ser Leu Glu Asp 
    850                 855                 860                 


Arg Val Lys Asn Gly Glu Ala Lys Glu Ile Val Ile Arg Asp Ile Pro 
865                 870                 875                 880 


Phe Ile His Pro Asp Arg Val Lys Tyr Thr Asp Arg Ser Thr Asp Glu 
                885                 890                 895     


Ala Ile Arg Lys Gln Ala Ala Arg Tyr Met Glu Ile Glu Asp Lys Asp 
            900                 905                 910         


Ala Asp Gly Asn Thr Val Ile His Arg Thr Thr Ile Met Leu Pro Asp 
        915                 920                 925             


Gly Met Phe Ile Thr Tyr Ile Asn Asp Ile Leu Arg Ser Thr Ala Lys 
    930                 935                 940                 


Ser Lys Glu Phe Arg Lys Phe Ile Ser Pro Leu Pro Ser Tyr Ala Ser 
945                 950                 955                 960 


Asp Ala Asp Arg Lys Lys Lys Ser Asp Glu Leu Lys Asn Thr Ala Tyr 
                965                 970                 975     


Thr Ile Ser Arg Phe Phe Glu Tyr Glu Leu Gly Asp Lys Ser Gln Leu 
            980                 985                 990         


Phe Tyr Tyr Ala Asn Asp Thr Leu  Asn Gly Asp Lys Gln  Glu Met Phe 
        995                 1000                 1005             


Ala Arg  Asn Tyr Lys Leu Phe  Gln Thr Leu Arg Gly  Ile Lys Ser 
    1010                 1015                 1020             


Gly Pro  Gly Lys Leu Pro Tyr  Tyr Leu Ser Pro Ser  Gln Ile Leu 
    1025                 1030                 1035             


Thr Gly  Val Lys Asn Ile Gln  Ser Glu Ile Asp Thr  Tyr Ile Lys 
    1040                 1045                 1050             


Asp Asn  Arg Gln Ser Arg Lys  Tyr Lys Ile Glu His  Pro Lys Phe 
    1055                 1060                 1065             


Gly Lys  Gln Lys Ile Phe Gly  Glu Arg Leu Met Ala  Tyr Leu Asn 
    1070                 1075                 1080             


Glu Glu  Asp Glu Lys Glu Arg  Lys Thr Ile Ser Ile  Leu Leu Ser 
    1085                 1090                 1095             


Glu Cys  Lys His Asn Glu Lys  Thr Ile Arg Arg Tyr  Lys Thr Gln 
    1100                 1105                 1110             


Asp Met  Val Leu Phe Leu Met  Ala Lys Asp Leu Leu  Gly Lys Tyr 
    1115                 1120                 1125             


Ile Lys  Asp Glu Asp Thr Gln  Glu Glu Asn Ser Leu  Phe Met Leu 
    1130                 1135                 1140             


His Asn  Val Cys Asp Asp Lys  Phe Leu Arg Arg Thr  Val Arg Tyr 
    1145                 1150                 1155             


Glu Phe  Pro Ile Arg Val Asn  Glu Glu Arg Thr Val  Arg Val Val 
    1160                 1165                 1170             


Gln Pro  Asn Met Ser Leu Lys  Asn Tyr Gly Glu Phe  Tyr Arg Leu 
    1175                 1180                 1185             


Leu Ser  Asp Glu Arg Phe Leu  Asn Val Ile Glu Arg  Phe Lys Asp 
    1190                 1195                 1200             


Ile Asp  Val Tyr Asn Tyr Asn  Lys Leu Met Ala Glu  Leu Asn Ser 
    1205                 1210                 1215             


Tyr Asp  Ser Lys Arg Ser Ser  Ile Phe Gly Ile Val  His Tyr Leu 
    1220                 1225                 1230             


Glu Glu  Ile Ile Tyr Gly Thr  Asn Asp Ile Leu Arg  Asp Glu His 
    1235                 1240                 1245             


Glu Asn  Glu Ala Gly Phe His  Val Glu Asp Asn Pro  Glu Lys Ala 
    1250                 1255                 1260             


Ala Arg  Arg Asn Asn Phe Arg  Ser Met Leu Tyr Ile  Tyr Asp Lys 
    1265                 1270                 1275             


Glu Ala  Glu Lys Glu Lys Arg  Asn Ala Ile Phe Glu  Leu Leu Ile 
    1280                 1285                 1290             


Ser Ile  Arg Asn Ala Phe Gly  His Asn His Leu Arg  Ile Pro Phe 
    1295                 1300                 1305             


Gln Glu  Trp Met Thr Asp Glu  Glu Lys Lys Ala Phe  Lys Ser Trp 
    1310                 1315                 1320             


Ile Ser  Lys Asp Asp Glu Val  Arg Glu Lys Gly His  Glu Arg Ile 
    1325                 1330                 1335             


Ala Pro  Pro Thr Ile Ala Glu  Arg Ile Leu Ala Tyr  Thr Glu Lys 
    1340                 1345                 1350             


Thr Ala  Glu Glu Thr Gly Ile  Ile 
    1355                 1360     


<210>  1732
<211>  1320
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1732

Met Arg Pro Asp Arg Asp Ala Thr Gln Arg Gln Ile Ile Ile Thr His 
1               5                   10                  15      


Tyr Gly Thr Phe Tyr Glu Ile Ser Lys Ile Met Cys Ile Phe Ala Lys 
            20                  25                  30          


Leu Asn Ile Gln Met Pro Ser Asn Asn Asn Ser Leu Asn Gln Phe Ile 
        35                  40                  45              


Thr Thr Met Asp Asn Asn Glu Thr Ser Ile Lys Gln Phe Val Leu Leu 
    50                  55                  60                  


Gly Glu Asp Asn Ser Gln Tyr Arg Asp Tyr Ala Gly Ser Tyr Phe Thr 
65                  70                  75                  80  


Lys Ala Asn Leu Asn Phe Tyr Arg Thr Met Lys Thr Val Phe Arg Arg 
                85                  90                  95      


Ser Gly Ile Met Lys Asp Asn Arg Leu Gly Asn Val Glu Trp Arg Asp 
            100                 105                 110         


Asp Asn Met Glu Thr Ala Leu Ser Ser Phe Asp Ile Thr Thr Ile Ser 
        115                 120                 125             


Ala Thr Gln Met Ser Ser Leu Ser Asp His Leu Phe Arg Asn Leu Pro 
    130                 135                 140                 


Met Phe Gly Pro Ile Met Ser His Asp Lys Asn Ala Phe Leu Ser Pro 
145                 150                 155                 160 


Leu Lys Arg Ala Lys Lys Ala Leu Asp Lys Ala Lys Lys Asp Leu Lys 
                165                 170                 175     


Asn Ala Lys Lys Ala His Gln Asp Glu Asp Lys Tyr Glu Lys Leu Lys 
            180                 185                 190         


Asn Val Ala Glu Ile Glu Tyr Asn Gln Gln Lys Glu Asn Phe Lys Asn 
        195                 200                 205             


Glu Met Tyr Gly Thr Glu Ala Lys Asp Met Trp Asp Lys Leu Ile Asn 
    210                 215                 220                 


Ile Ala Gly Ala Leu Leu Tyr Tyr Arg Asn Leu Tyr Thr His Lys Asn 
225                 230                 235                 240 


Pro Tyr Ser Thr Glu Asp Asp Glu Asn Lys Gln Lys Glu Arg Glu Ile 
                245                 250                 255     


Lys Ile Ala Lys Trp Met Asn Ser Val Phe Glu Gly Glu Lys Gly Ile 
            260                 265                 270         


Leu Ile Glu Arg Lys Lys Tyr Lys Tyr Glu Asp Thr Leu Phe Leu Ile 
        275                 280                 285             


Asp His Gln Lys Glu Thr Asp Arg Met Glu Lys Arg Gly Asn Lys Tyr 
    290                 295                 300                 


Val Glu Arg Asp Asn Phe Tyr Phe Lys Ile Lys Ile Leu Asp Glu Asn 
305                 310                 315                 320 


Asn Lys Cys Ile Gly Leu Thr Asp Phe Gly Arg Phe Phe Phe Cys Ser 
                325                 330                 335     


Leu Phe Leu Arg Arg Ser Asp Ser Glu Leu Tyr Ala Lys Ser Val Lys 
            340                 345                 350         


Leu Phe Glu Asn Ser Pro Tyr Cys Leu Thr Glu Gln Glu Leu Lys Ile 
        355                 360                 365             


Lys Gln Ala Glu Glu Asn Lys Arg Ala Ala Thr Glu Ser Gln Lys Ser 
    370                 375                 380                 


Asp His Gln Val Asn Pro Lys Thr Ile Asp Ile Thr Glu Ser Ala Gln 
385                 390                 395                 400 


Ile Asn Ile Ile Arg Glu Met Met Gln Met His Arg Ile Arg Ile Pro 
                405                 410                 415     


Arg Glu Lys Lys Ile Asp Phe Thr Pro Ser Glu Ser Met Leu Leu Met 
            420                 425                 430         


Asp Ile Leu Asn Glu Leu Arg Arg Cys Pro Gln Glu Leu Tyr Asp Thr 
        435                 440                 445             


Phe Asn Gln Thr Asp Lys Leu Lys Phe Val Val Asp Asn Pro Asn Glu 
    450                 455                 460                 


Asp Pro Glu Ser Asp Ser Lys Ile Thr Leu Thr Arg Ser Lys Asp Arg 
465                 470                 475                 480 


Phe Ala His Leu Ala Leu Arg Leu Ile Asp His Thr Asp Ala Leu Gly 
                485                 490                 495     


Ser Ile Arg Phe His Leu Arg Leu Gly Leu Phe Arg Phe Arg Phe Tyr 
            500                 505                 510         


Asp Lys Lys Leu Ile Asp Asn Ser Glu Thr Leu Arg Arg Val His Lys 
        515                 520                 525             


Glu Ile Asn Gly Phe Gly Lys Trp His Val Val Glu Ser Leu Arg Arg 
    530                 535                 540                 


Glu Lys Trp Gly Lys Tyr Asn Gln Lys Phe Glu Leu Asn Asp Asp Gly 
545                 550                 555                 560 


Leu Leu Gln Phe Val Pro Asp Ser Ala Glu Ser Asp Pro Tyr Ile Thr 
                565                 570                 575     


Asp Trp Gln Thr Thr Tyr Asn Ile His Ala Asn Arg Ile Gly Leu Phe 
            580                 585                 590         


Trp Asn Gly Asn Ser Gln Ser Glu Asp Tyr Tyr Ile Pro Glu Leu Lys 
        595                 600                 605             


Thr Met Val Asp Glu Asn Ser Lys Val Ile Ala Pro Val Glu Met Lys 
    610                 615                 620                 


Ile Pro Leu Cys Ser Leu Ser Ile Tyr Asp Leu Pro Ala Ile Leu Phe 
625                 630                 635                 640 


Tyr Thr Tyr Ile Phe Asn Leu Tyr Asn Gly Asn Arg Leu Gly Leu Pro 
                645                 650                 655     


Asn Ala Glu Lys Ile Ile Lys Asn Lys Tyr Thr Ala Leu Asn Glu Phe 
            660                 665                 670         


Phe Gly Phe Ala Lys Lys Ser Glu Ser Thr Pro Glu Glu Leu Ile Lys 
        675                 680                 685             


Lys Gln Glu Glu Leu Asn Leu His Asp Ser Glu Ile Pro Glu Arg Leu 
    690                 695                 700                 


Leu Tyr Leu Met Gly Lys Ile Lys Thr Pro Lys Gly Lys Ile Ala Glu 
705                 710                 715                 720 


Trp Lys Pro Asn Ser Lys Arg Asn Asn His Ala Lys Glu Leu Leu Lys 
                725                 730                 735     


Lys Ile Ile Glu Glu Asp Glu Trp Arg Ile Lys Ser Phe Lys Asp Lys 
            740                 745                 750         


Lys Asn Lys Ile Glu Asp Lys Asn Arg Tyr Gly Arg Lys Asp Tyr Ser 
        755                 760                 765             


Asp Ile Arg His Gly Val Leu Ala Lys Tyr Leu Val Glu Ser Met Met 
    770                 775                 780                 


Met Trp Gln Pro Gly Lys Gln Lys Ala Glu Thr Lys Ile Ser Ser Ala 
785                 790                 795                 800 


Asn Tyr Arg Ala Leu Arg Asp Tyr Leu Ser Asn Tyr Asn Asn Asn Ser 
                805                 810                 815     


Asn Asn Leu Gln Phe Val Leu Lys Ala Ala His Leu Ile Asp Ser Glu 
            820                 825                 830         


Asn Pro His Pro Phe Ile Asn Lys Val Lys Gly Ser Asn Ile Glu Leu 
        835                 840                 845             


Tyr Tyr Thr Asn Tyr Leu His Glu Glu Leu Lys His Ala Arg Gly Ile 
    850                 855                 860                 


Leu Ser Glu Leu Glu Asp Asn Asn Tyr Thr Gly Asp Lys Lys Glu Ile 
865                 870                 875                 880 


Ile Pro Pro Phe Ala Lys Pro Glu Ser Asp Lys Trp Asn Lys Lys Ser 
                885                 890                 895     


Asn Thr Ile Gln Ser Cys Ala Ala Lys Tyr Leu Glu His Pro Ile Gln 
            900                 905                 910         


Leu Pro Asp Gly Leu Phe Thr Gln Ala Ile Ile Asp Leu Leu Lys Ala 
        915                 920                 925             


Ala Asp Ile Asp Glu Thr Ile Lys Asn Asp Ala Thr Lys Asp Ser Asn 
    930                 935                 940                 


Ala Thr Tyr Ile Ile Arg Tyr Trp Phe Asp Lys Val Gly Gln Asp Ser 
945                 950                 955                 960 


Pro Gln Leu Phe Tyr Asp Ser Thr Leu Phe Lys Arg Ser Tyr Lys Phe 
                965                 970                 975     


Ile Asp Lys Cys Phe Leu Gln Lys Asp Glu Gly Asn Gln Thr Ile Lys 
            980                 985                 990         


His Phe Leu Thr Glu Lys Glu Ile  Leu Asp Asn Ile Lys  Asn Phe Arg 
        995                 1000                 1005             


Gly Glu  Thr Gly Ser Leu Ala  Gly Lys Leu Tyr Pro  Lys Asp Lys 
    1010                 1015                 1020             


Leu Glu  Glu Ser Lys Lys Ser  Ile Ile Asn Gln Leu  Asn Glu Val 
    1025                 1030                 1035             


Lys Asp  Lys Glu Lys Ala Ile  Arg Arg Tyr Arg Val  Gln Asp Ile 
    1040                 1045                 1050             


Ala Leu  Phe Leu Leu Ala Arg  Lys Arg Leu Val Glu  Leu Leu Ser 
    1055                 1060                 1065             


Lys Ser  Glu Asn Ser Asn Arg  Asn Glu Ala Arg Val  Glu Thr Thr 
    1070                 1075                 1080             


His Ser  Gln Asn Asn Ile Ser  Lys Lys Ala Asn Asn  Leu Lys Leu 
    1085                 1090                 1095             


Lys Asp  Phe Gly Phe Asp Glu  Asp Phe His Phe Leu  Ser Gly Ser 
    1100                 1105                 1110             


Glu Asp  Asn Gly Asp Gly Leu  Leu Phe Glu Tyr Glu  Tyr Ile Val 
    1115                 1120                 1125             


Asp Asn  Asp Ala Asn Lys Lys  Ile Met Ile Val Gln  Glu Gly Leu 
    1130                 1135                 1140             


Ser Leu  Lys Asn Tyr Gly Asn  Ile Tyr Arg Val Leu  Gly Asp Asn 
    1145                 1150                 1155             


Arg Ile  Lys Thr Leu Met Gln  Leu Leu Tyr Glu Ile  Lys Lys Asp 
    1160                 1165                 1170             


Lys Val  Glu Asp Gly Thr Ile  Thr Phe Thr Phe Ala  Glu Leu Val 
    1175                 1180                 1185             


Lys Glu  Leu Thr Asn Asn Asp  Lys Leu His His Glu  Phe Tyr Arg 
    1190                 1195                 1200             


Leu Phe  Gln Asn Ile Glu Gln  Glu Ala Tyr Asp Gly  Thr Gly Gly 
    1205                 1210                 1215             


Phe Asp  Ala Asn Lys Lys Asn  Lys Glu Val Leu Asp  Asn Pro Asp 
    1220                 1225                 1230             


Asp Glu  Gln Phe Phe Phe Val  Arg Gln Arg Lys Asn  Gly Glu Val 
    1235                 1240                 1245             


Thr Thr  Lys Glu Ala Val Arg  Asn Ser Phe Lys Lys  Leu Ile Glu 
    1250                 1255                 1260             


Leu Leu  Lys Gln Tyr Ser Thr  Asp Glu Gly Ile Ile  Val Gln Leu 
    1265                 1270                 1275             


Arg Asn  Asp Ala Ile His Asp  Arg Tyr Pro Glu Pro  Ile Ala Glu 
    1280                 1285                 1290             


Met Glu  Leu Lys Glu Thr Gly  Ile Thr Glu Ser Leu  Ile Glu Tyr 
    1295                 1300                 1305             


Leu Asn  Asn Leu Ile Lys Lys  Asn Gln Glu Gln Leu  
    1310                 1315                 1320 


<210>  1733
<211>  1090
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1733

Met Glu Lys Val Thr Asn Thr Asp Lys Asn Ile Lys Pro Asn Tyr Arg 
1               5                   10                  15      


Ser Phe Lys Glu Glu Glu Ser Lys Pro Phe Tyr Ala Ala Tyr Leu Asn 
            20                  25                  30          


Thr Ala Ile His Asn Ile Tyr Thr Val Phe Lys Asp Ile Ser Glu Ser 
        35                  40                  45              


Leu Gly Ile Ala Phe Asn Phe Lys Asn Asp Tyr Gln Ile Leu Gly Ser 
    50                  55                  60                  


Asp Leu Ile Lys Lys Leu Glu Glu Asn Asn Glu Pro Glu Leu Ser Gln 
65                  70                  75                  80  


Lys Ile Ile Glu Arg Leu Asp Arg Gln Phe Ser Phe Leu Lys Thr Leu 
                85                  90                  95      


Thr Leu His Asn Ala Lys Asn Arg Thr Gln Ala Asp Ala Pro Leu Ala 
            100                 105                 110         


Asp Ala Ile Asp Tyr His Gln Val Ile Lys Leu Trp Val Ser Gln Leu 
        115                 120                 125             


Met Asp Tyr Arg Asn Phe Tyr Ser His Ala Leu His Val Pro Ile Gln 
    130                 135                 140                 


Met Asp Pro Phe Ile Val Asp Gly Met Arg Ser Leu Tyr Asp Ala Asp 
145                 150                 155                 160 


Trp Lys Glu Phe Lys Glu Arg Lys Thr Leu Ser Thr Glu Asp Thr Ala 
                165                 170                 175     


His Leu Ile Arg Leu Gly Lys Asn Gly Glu Ser Arg Asn Phe His Tyr 
            180                 185                 190         


Ala Phe Leu Asp Lys Gln Gly Asn Ile Thr Glu Lys Gly Phe Leu Tyr 
        195                 200                 205             


Phe Thr Cys Leu Trp Leu Glu Lys Lys Asp Ala Gln Glu Leu Leu Lys 
    210                 215                 220                 


Lys His Lys Gly Phe Lys Arg Gly Glu Ser Lys Ser Gln Lys Ala Thr 
225                 230                 235                 240 


Leu Glu Lys Phe Ile Trp Phe Gly Thr Arg Val Pro Lys Pro Arg Leu 
                245                 250                 255     


Thr Ser Asp Asn Ser Gln Gln Gly Leu Phe Met Asp Met Val Asn Asp 
            260                 265                 270         


Leu Lys Arg Cys Pro Val Val Leu Phe Asp Leu Leu Ser Glu Ala Asp 
        275                 280                 285             


Lys Ala Arg Phe Tyr Thr Glu Asp Glu Phe Gly Ala Asp Glu Glu Asp 
    290                 295                 300                 


Gly Tyr Glu Ala Lys Pro Phe Leu Ile Arg Lys Thr Asn Arg Phe Tyr 
305                 310                 315                 320 


Tyr Phe Ala Met Arg Phe Leu Glu Gln Arg Phe Glu His Leu Lys Phe 
                325                 330                 335     


His Ile Asp Leu Gly Asn Tyr Cys Tyr Lys Thr Tyr Asp Gln Val Ile 
            340                 345                 350         


Glu Gly Val Thr Arg Lys Arg Arg Trp Ile Ser Arg Ile Thr Ala Phe 
        355                 360                 365             


Gly Asn Leu Thr Asp Phe Arg Glu Ser Asp Pro Pro Leu Ala Trp Arg 
    370                 375                 380                 


Glu Lys Leu Leu Ser Pro Gly Glu Thr Asp Lys Pro Ser Thr Tyr Ile 
385                 390                 395                 400 


Thr Pro Thr Thr Ala His Tyr His Phe Asp Pro Ser Ser Lys Val Met 
                405                 410                 415     


Ala Ile Gly Leu Lys Trp Val Glu Asp Tyr Arg Lys Asp Ala Ile Trp 
            420                 425                 430         


Pro Asp Ile Glu Thr Ala Asp Val Asp Gln Lys Tyr Arg Asn Val Val 
        435                 440                 445             


Pro Asp Phe Trp Leu Ser Leu Tyr Glu Leu Pro Ser Leu Val Phe Tyr 
    450                 455                 460                 


Gln Ile Leu His Glu Lys Gly Leu Ile Glu His Ser Ala Glu Ser Ile 
465                 470                 475                 480 


Ile Lys Ser Tyr Arg Glu Lys Leu Asn Lys Gly Phe Leu Asn Asn Val 
                485                 490                 495     


Ala Glu Lys Arg Ile Leu Pro Gly Leu Ser Lys Val Glu Leu Glu Lys 
            500                 505                 510         


Glu Leu Lys Gln Arg Gly Leu Asp Ile Gln Cys Ile Pro Lys Thr Val 
        515                 520                 525             


Val Asn Tyr Leu Leu Ser Lys Asp Pro Glu Pro Ile Glu Ser Lys Ala 
    530                 535                 540                 


Lys Ala Arg Leu Ala Arg Leu Lys Glu Glu Asn Thr Cys Leu Leu Ser 
545                 550                 555                 560 


Gln Val Glu Arg Gln Glu Pro His Tyr Arg Met Lys Pro Gly Ser Lys 
                565                 570                 575     


Asn His Ile Ala Pro Lys Ala Gly Thr Ile Ala Asp Phe Leu Ala His 
            580                 585                 590         


Asp Met Leu Leu Leu Gln Lys Pro Ile Lys Gln Asp Gln Gly Lys Ala 
        595                 600                 605             


Asn Ser Thr Glu Phe Gln Ile Leu Gln Ala Lys Leu Ala Tyr Phe Asn 
    610                 615                 620                 


Gln Asn Lys Glu Ser Leu Asn Glu Thr Phe Lys Leu Cys Asn Leu Thr 
625                 630                 635                 640 


Glu Ala Pro Asn Ala His Pro Phe Leu Gly Arg Ile Glu Leu Ala Lys 
                645                 650                 655     


Cys Lys Gly Ile Val Asp Phe Tyr Lys Lys Tyr Leu Leu Gln Arg Ala 
            660                 665                 670         


Lys Phe Leu Asp Gln Cys Ile Met Asp Lys Ser Phe Lys Glu Tyr His 
        675                 680                 685             


Phe Leu Lys Ile Lys Asp Thr Ser Asp Thr Ile Lys Ala Leu Ile Glu 
    690                 695                 700                 


Lys Gln Gln Asn Ala Val Leu Asn Leu Pro Arg Gly Leu Phe Lys Ser 
705                 710                 715                 720 


His Ile Gln Thr Ala Leu Thr Lys Gly Asp Thr Thr Ser Lys Leu Leu 
                725                 730                 735     


Lys Asp Val Leu Ala Asp Asn Thr His Asn Asn Ala Phe Ile Ile Gln 
            740                 745                 750         


Glu Tyr Phe Lys Arg Val Glu Lys Asp Glu Ser Gln Thr Phe Tyr Glu 
        755                 760                 765             


Phe Lys Arg Ser Tyr Glu Leu Leu Thr Lys Leu Tyr Asp Thr Arg Arg 
    770                 775                 780                 


Pro Lys Asp Arg Lys Pro Ala Pro Pro Lys Phe Phe Ala Pro Glu Glu 
785                 790                 795                 800 


Leu Thr Glu Lys Tyr Arg Asp Ile Lys Lys Lys Leu Ala Leu Lys Ile 
                805                 810                 815     


Asp Gln Lys Leu Ala Gly Val Glu Lys Gly Ser Pro Glu Glu Ala Arg 
            820                 825                 830         


Ile Arg Ser Asn Phe Ser Lys Gln Tyr Lys Lys Leu Met Asp Asp Glu 
        835                 840                 845             


Lys Gln Ile Arg Leu Phe Lys Thr Cys Asp Met Val Gln Phe Leu Met 
    850                 855                 860                 


Val Asp Gln Leu Tyr Gln Gln Leu Gly Leu Glu Tyr Lys Ser Leu Val 
865                 870                 875                 880 


Lys Lys Asp Gln Thr Gly Thr Ser Phe Gln Met Gly Lys Glu Tyr Ser 
                885                 890                 895     


Leu Arg Glu Ile Ile Pro Asp Gly Gln Asp Gly Ile Leu Ser Leu Lys 
            900                 905                 910         


Thr Gln Val Lys Leu Pro Leu Tyr Leu Asp Lys Gly Asp Ser Thr Glu 
        915                 920                 925             


Cys Lys Ile Ile Val Arg Asp Lys Met Lys Ile Lys Asn Tyr Gly Asp 
    930                 935                 940                 


Phe Arg Leu Phe Leu Lys Asp Arg Arg Ile Lys Gly Leu Leu Pro Tyr 
945                 950                 955                 960 


Ile Asp Ala Glu Glu Ile Ala Tyr Glu Ala Leu Lys Arg Glu Leu Glu 
                965                 970                 975     


Glu Phe Asp Lys Cys Arg Arg Ala Val Ile Ala Glu Ile Leu Arg Phe 
            980                 985                 990         


Glu Gln Asn Thr Val Lys Lys Phe  Asn Met Glu Leu Ser  Gly Lys Arg 
        995                 1000                 1005             


Phe Phe  Asn His Glu Lys Phe  Leu Glu Lys Gly Ser  Gly Tyr Ser 
    1010                 1015                 1020             


Ala Glu  Glu Ile Glu Ser Met  Ser Leu Leu Arg Asn  Ala Phe Phe 
    1025                 1030                 1035             


His Ser  Ile Tyr Pro Ser Tyr  Glu Gln Phe Arg Gly  Lys Val Asn 
    1040                 1045                 1050             


Gly Glu  Arg Phe Asn Glu Leu  Lys Asp Tyr Thr Ala  Asp Asp Pro 
    1055                 1060                 1065             


Glu Val  Asp Gln Lys Ser Ile  Ile Gln Gln Leu Lys  Asn Leu Thr 
    1070                 1075                 1080             


Leu Ile  Tyr Tyr Arg Gly Leu  
    1085                 1090 


<210>  1734
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1734

Met Met Tyr Asn Asp Ser Gln Gly Asn Asn Met Glu Gln Asn Ser Lys 
1               5                   10                  15      


Ser Phe Leu Gly Ile Phe Leu Asn Gln Ala Arg Leu Asn Ala Tyr Ile 
            20                  25                  30          


Thr Leu Cys His Ile Ser Asp Leu Leu Gly Glu Lys Thr Val Asp Glu 
        35                  40                  45              


Asp Ser Leu Ala Lys Met Pro Val Leu Thr Phe Leu Asp Asn Trp Gly 
    50                  55                  60                  


Asp Pro Ile Lys Ser Arg Arg Thr Tyr Glu Leu Ile His Glu His Phe 
65                  70                  75                  80  


Pro Met Leu Glu Ile Ile Tyr Lys Ala Ile Glu Arg Arg Glu Ala Asn 
                85                  90                  95      


Asn Ser Asp Ala Lys Gly Gly Gly Val Asp Ile Asn Val Arg Ala Ala 
            100                 105                 110         


Glu Tyr Arg Lys Ile Leu Gln Thr Leu Leu Ile Ala Ile Asn Cys Lys 
        115                 120                 125             


Arg Asn Glu Cys Cys His Ala Lys Ser Ala Asp Thr Leu Ala Glu Lys 
    130                 135                 140                 


Val Val Val Lys Glu Leu Val Arg Tyr Leu Glu Asp Cys Phe Asp Ala 
145                 150                 155                 160 


Ser Val Asp Glu Val Lys Asn Arg Leu Ser Leu Tyr Glu Asp Asp His 
                165                 170                 175     


Asn Asp Asn Ser Pro Lys Asp Glu Cys Leu His Leu Arg Arg Phe Lys 
            180                 185                 190         


Gly Val Glu Lys Val Asn Gly Lys Gly Lys Pro Lys Ala Asn Pro Phe 
        195                 200                 205             


Phe Gln Tyr Ala Phe Lys Asp Asp Asn Gly Leu Leu Thr Asp Lys Gly 
    210                 215                 220                 


Leu Ala Phe Leu Val Ser Ile Phe Leu Asp Lys Asp Asp Thr Phe Lys 
225                 230                 235                 240 


Phe Leu Lys Thr Ser Asp Leu His Gly Phe Lys Asn Asp Thr Glu Asn 
                245                 250                 255     


Lys Phe Arg Ala Thr Leu Leu Ser Tyr Cys Thr Trp Arg Ile Lys Leu 
            260                 265                 270         


Pro His Pro Lys Val Arg Ser Asp Asp Asp Ile Thr Gly Leu Ala Leu 
        275                 280                 285             


Asp Met Leu Gly Asp Ile Glu Lys Cys Pro Lys Glu Leu Phe Arg Leu 
    290                 295                 300                 


Leu Ser Thr Glu Lys Gln Lys Asp Phe Arg Val Lys Glu Ala Leu Asp 
305                 310                 315                 320 


Gly Asp Glu Tyr Ser Ser Glu Ile Leu Leu Met Arg Tyr Ser Asp Arg 
                325                 330                 335     


Phe Pro Tyr Leu Ala Leu Arg Tyr Cys Asp Glu Met Glu Val Phe Ala 
            340                 345                 350         


Asn Leu Arg Phe His Ile Asp Leu Gly Arg Tyr Tyr Phe Lys Phe Tyr 
        355                 360                 365             


Pro Lys Lys Ala Ala Asp Gly Ile Glu His Pro Arg Gln Leu Asp Lys 
    370                 375                 380                 


Asn Leu Lys Thr Phe Gly Arg Ile Arg Glu Val Lys Asp Gln Val Lys 
385                 390                 395                 400 


Glu Gln Trp Glu Asn Asn Gly Met Val Lys Ala Pro Asp Glu Ile Lys 
                405                 410                 415     


Glu Gly His Asn Glu Pro Tyr Ile Arg Lys Thr Thr Pro His Tyr His 
            420                 425                 430         


Ile Val Asp Asn Gln Ile Cys Leu Glu Ile Ser Ser Gly Lys Val Val 
        435                 440                 445             


Leu Pro Glu Leu Glu Gln Asn Ser Gly Gly Gln Lys Thr Pro Pro Arg 
    450                 455                 460                 


Ala Trp Leu Ser Val Tyr Glu Leu Pro Gly Met Ile Phe His Gly Leu 
465                 470                 475                 480 


Gly Tyr Gly Phe Glu His Thr Glu Leu Leu Ile Lys Gln Tyr Ile Lys 
                485                 490                 495     


Glu Gln Arg Glu Ile Cys Arg Lys Ile Cys Glu Thr Gly Val Ile Pro 
            500                 505                 510         


Glu Asn Ala Gly Glu Phe Leu Pro Glu Gly Leu Lys Asp Thr Gly Thr 
        515                 520                 525             


Ser Asn Ala Lys Gln Asn Asn Tyr Ala Gly Glu Lys Leu Gln Arg Met 
    530                 535                 540                 


Leu Glu Asp Thr Lys His Gln Ile Thr Ala Ile Lys Thr Thr Lys Gln 
545                 550                 555                 560 


Arg Met Asp Asp Lys Ser Asn Lys Pro Gly Lys Lys Lys Phe Phe Asp 
                565                 570                 575     


Ile Arg Ala Gly Lys Leu Ala Asp Phe Leu Ala Arg Asp Ile Ile Arg 
            580                 585                 590         


Leu Gln Pro Phe Asp Pro Ala Lys Lys Gly Lys Asp Lys Thr Thr Ala 
        595                 600                 605             


Leu Asn Phe Gln Val Leu Gln Glu Thr Leu Ala Phe Phe Gly Ala Lys 
    610                 615                 620                 


Lys His Ser Leu Glu Arg Ile Trp Lys Glu Leu Gly Leu Ile Gly Gly 
625                 630                 635                 640 


Lys Phe Glu His Pro Phe Leu Thr Lys Leu Gly Asn Pro Val Ala Cys 
                645                 650                 655     


Arg Ser Ile Val Asp Phe Tyr Gln Val Tyr Leu Asp Lys Arg Leu Glu 
            660                 665                 670         


Tyr Leu Glu Ser Leu Lys Glu Ser Glu Leu Lys Ser Ile Gln Phe Leu 
        675                 680                 685             


Arg Pro Ser Arg Gln Arg Tyr Ala Ala Gly Lys Arg Asp Leu Lys Thr 
    690                 695                 700                 


Ile Ala Glu Arg Leu Leu Glu Arg Pro Val Asn Ile Pro Asn Asp Leu 
705                 710                 715                 720 


Phe Arg Glu Asp Ile Glu Lys Phe Val Gln Asn Ile Ile Pro Ser Ile 
                725                 730                 735     


Asn Asn Asp Ala Ile Glu Ile Asp Asn Glu Thr Gly Arg Lys Lys Leu 
            740                 745                 750         


Asn Thr Ala Tyr Leu Ile Gln Glu Tyr Phe Arg Cys Lys Glu Gly Asn 
        755                 760                 765             


His Gln Pro Val Tyr His Cys Glu Lys Thr Tyr Gln Val Val Ser Lys 
    770                 775                 780                 


Ala Gly Glu Tyr Ser Lys Lys Ala Arg Asn Arg Ser Ile Ala Glu Ala 
785                 790                 795                 800 


Leu Leu Ser Ile Ser Pro Gln Met Gly Tyr Lys Lys Met Glu Ser Phe 
                805                 810                 815     


Ile Lys Glu Asn Ile Pro Asp Glu Gly Arg Tyr Glu Pro Glu Asn Leu 
            820                 825                 830         


Arg Asp Tyr Leu Phe Lys Glu Cys Arg Glu Phe Lys Gly Asn Glu Arg 
        835                 840                 845             


Thr Leu Arg Arg Phe Lys Val Gln Asp Ala Val Ile Phe Met Met Phe 
    850                 855                 860                 


Lys Asp Ile Leu Lys Lys Val Phe Asp Cys Glu Val Thr Gly Gln Val 
865                 870                 875                 880 


Ser Thr Glu Asp Glu Thr Glu Val Thr Ala Val Gln Asp Glu Asn Asn 
                885                 890                 895     


Pro Ala Asn Pro Ala Arg Lys Leu Leu Glu Leu Lys Leu Glu Asn Ile 
            900                 905                 910         


Asp Pro Ala Lys Tyr Arg Asp Lys Asp Ser Ile Phe Gln Tyr Pro Met 
        915                 920                 925             


Pro Pro Ser Thr Thr Asp Ile Ser Ile Thr Phe Asn Ser Asn Leu Asn 
    930                 935                 940                 


Tyr Glu Lys Asp Tyr Val Glu Tyr Ile Asp Lys Lys Tyr Lys Asp Cys 
945                 950                 955                 960 


Ala Gly Tyr Ser Thr His Gly Asn Lys Arg Glu Val Thr Tyr Arg Ile 
                965                 970                 975     


Val Leu Lys Asn Val Lys Leu Arg Asp Ile Gly Lys His Arg Arg Tyr 
            980                 985                 990         


Phe Arg Asp Arg Arg Leu Pro Gly  Leu Leu Ser Trp Arg  Tyr Met Pro 
        995                 1000                 1005             


Gly Asp  Glu Ile Asp Cys Ala  Glu Ile Glu Glu Gln  Ile Glu Ala 
    1010                 1015                 1020             


Tyr Glu  Gln His Arg Val Glu  Ile Ala Gly Leu Leu  Tyr Gly Leu 
    1025                 1030                 1035             


Glu Asn  Lys Val Ile Asp Cys  Phe Met Pro Lys Asp  Ala Leu Gly 
    1040                 1045                 1050             


Asp Asp  Tyr Ile Asp Phe Asn  Arg Ile Ile Asp Thr  Ile Lys Asp 
    1055                 1060                 1065             


Lys Leu  Thr Gly Val Asp Glu  Lys Ala Glu Thr Leu  Arg Lys Ile 
    1070                 1075                 1080             


Arg Asn  Gly Val Tyr His Asn  Gln Phe Pro Val Phe  Thr Asp Ala 
    1085                 1090                 1095             


Ile Glu  Lys Ala Asp Gly Gly  Ser Ile Ala Glu Lys  Met Leu Ser 
    1100                 1105                 1110             


Ile Thr  Lys Arg Tyr Val Glu  Gln Ile Thr Lys Glu  Ile Asn 
    1115                 1120                 1125         


<210>  1735
<211>  1262
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1735

Leu Gln Asn Ala Lys Tyr Ile Arg Asn Phe Ala Lys Arg Arg Pro Asn 
1               5                   10                  15      


Asn Tyr Tyr Ser Lys Gln Ser Val Lys Gln Lys Tyr Met Ile Ile Lys 
            20                  25                  30          


Glu Ser Lys Gln Arg Lys Asp Lys Val Arg Thr Gln Thr Glu Asp Ser 
        35                  40                  45              


Gln Leu Ser His Asn Arg Arg Ser Pro Lys Ala Gln Met Pro Tyr Thr 
    50                  55                  60                  


Glu Asn Asp Lys Leu Arg Ser Val Tyr Ala Ala Tyr Leu Asn Met Ala 
65                  70                  75                  80  


Arg Met Asn Leu Tyr Asn Thr Leu Arg Phe Ile Gly His Leu Tyr Gly 
                85                  90                  95      


Met Asp Asp Asn Ile Gln Glu Gly Glu Met Asp Lys Met Lys Val Ala 
            100                 105                 110         


Asn Phe Ala Asn His Pro His Leu Glu Lys Arg Leu Ser Val Arg Lys 
        115                 120                 125             


Ala Leu Leu Lys His Leu Pro Phe Leu His Cys Met Ala Gln Ala Tyr 
    130                 135                 140                 


Val Asn Thr Glu His Lys Tyr Thr Asp Asp Asn Asp Leu Gln Lys Val 
145                 150                 155                 160 


Leu Leu Asn Ile Ile Asn Val Val Ser Asn Gln Arg Asp His Leu Thr 
                165                 170                 175     


His Ala Asn Pro Tyr Asn Asn Asp Ala Asp Trp Ala Lys Gln Lys Glu 
            180                 185                 190         


Ile Glu Lys Gln Leu Leu Glu Pro Leu Glu Lys Ala Phe Met Phe Ser 
        195                 200                 205             


Lys His Lys Val Glu Thr Ile Phe Asp Tyr Ser Lys Ser Asp Met Ser 
    210                 215                 220                 


Phe Ile Asp Arg Leu Glu Arg Met Met Asp Thr Gly Asp Thr Ile Ile 
225                 230                 235                 240 


Val Lys Glu Asn Asn Lys Glu Arg Glu Leu Arg Asp Asn Gln Asp His 
                245                 250                 255     


Ser Asp Tyr Tyr Phe Arg Leu Arg Thr Pro Glu Gly Asp Ala Leu Ser 
            260                 265                 270         


Thr Val Gly Leu Thr Phe Leu Ile Cys Lys Leu Leu His Lys Lys His 
        275                 280                 285             


Ala Thr Ile Phe Ala Gln Arg Thr Gly Leu Phe Leu Glu Gln Ser His 
    290                 295                 300                 


Leu Asp Gly Tyr Ser Pro Phe Ser Lys Arg Glu Asn Glu Ile Met Phe 
305                 310                 315                 320 


Asn Ile Phe Cys His Glu Arg Ile Arg Leu Pro Lys Gly Arg Leu Glu 
                325                 330                 335     


Ser Thr Thr Asp Pro Met Ala Leu Gly Leu Asp Met Leu Ala Glu Leu 
            340                 345                 350         


Gln Lys Cys Pro Ala Glu Leu Phe Asn Thr Phe Gly Pro Ser Asp Arg 
        355                 360                 365             


Lys Leu Phe Glu Val Arg Asn Glu Asp Phe Ser Thr Asp Ser Ser Thr 
    370                 375                 380                 


Glu Asp Ile Ile Leu Met Arg Arg Tyr Gly Asp Arg Phe Ala Arg Leu 
385                 390                 395                 400 


Ala Met Gln Tyr Ile Asp Ser Phe Asn Ala Asp Pro Asn His Arg Asn 
                405                 410                 415     


Lys Arg Asp Ser Ala Pro Leu Pro Gly Met Ala Phe Gln Val Ser Val 
            420                 425                 430         


Gly Lys Phe Arg His Thr Phe Tyr Glu Arg Ala Pro Phe His Glu Gly 
        435                 440                 445             


Val Lys Asp Arg Val Arg Val Leu Gln Lys Glu Ile Asn Gly Phe Gly 
    450                 455                 460                 


Pro Leu Thr Lys Ile Glu Asp Leu Arg Gln Thr Asp Tyr Ala Leu Phe 
465                 470                 475                 480 


Ile Arg Gln Val Asn Asp Asp Ser Ser Asp Arg Leu Tyr Asp Pro Asp 
                485                 490                 495     


Thr Ala Gln Thr Arg Pro Tyr Ile Thr Asp His His Ala Ser Tyr Ala 
            500                 505                 510         


Ile Thr Gly Asp Arg Ile Gly Leu Met Trp Asn Asp Glu Asn Val Gln 
        515                 520                 525             


Val Leu Asn Asn Asp Thr Leu Cys Tyr Leu Pro Glu Leu Pro Ile Pro 
    530                 535                 540                 


Thr Ala Thr Asp Asp Ser Lys Lys Pro Trp Asn Val Asp Leu Thr Val 
545                 550                 555                 560 


Phe Asn Arg Ser Asn Gly Gly His Pro Lys Gly Asn Ile Ala Pro Arg 
                565                 570                 575     


Ala Trp Leu Ser Ile Tyr Asp Leu Pro Ala Leu Ile Phe Leu His Phe 
            580                 585                 590         


Leu Gly Gly Lys Pro Ala Ser Val Ile Lys Asp Thr Tyr Asn Ser Leu 
        595                 600                 605             


Met Lys Leu Phe Asp Asp Ile Ala Glu Gly Arg Arg Asp Pro Tyr Phe 
    610                 615                 620                 


Lys Gly Gln Ile Pro Gln Asp Pro Asn Ser Arg Lys Lys Val Ile Leu 
625                 630                 635                 640 


Ser Leu Arg Glu Gln Leu Thr Pro His Leu Met Thr Asp Tyr Gly Leu 
                645                 650                 655     


His Thr Arg Asp Ile Pro Asp Lys Ile Val Glu Tyr Leu Ile Gly Glu 
            660                 665                 670         


Gly Leu Ala Ala Asn Glu Gln Thr Ala Ile Leu His Ala Glu Glu Arg 
        675                 680                 685             


Phe Arg Lys Trp Cys Asp Ile Lys Val Lys Ala Met Lys Lys Asp Leu 
    690                 695                 700                 


Asp Leu Arg Ile Glu His Phe Asn Lys Asp Lys Glu Gln Ile Gly Asn 
705                 710                 715                 720 


Ser Ser Asn Arg Ile Gly Ser Lys Arg Tyr Val Asp Leu Arg Pro Gly 
                725                 730                 735     


Ser Leu Ala Arg Tyr Leu Ala Lys Asp Met Ile Ala Met Val Asp Pro 
            740                 745                 750         


Lys Asp Gly Ala Lys Pro Ser Gly Leu Asp Phe Thr Leu Leu Gln Ala 
        755                 760                 765             


Ala Ile Ala Thr Tyr Gln Gly Asn Gly Cys Pro Leu Glu Lys Thr Glu 
    770                 775                 780                 


Leu Gly Ala Thr Ile Lys Lys Ala Phe Ala Trp Gln Ala His Pro Phe 
785                 790                 795                 800 


Leu Pro Lys Ile Met Asn Leu Thr Val Ser Asp Thr Ile Asp Leu Tyr 
                805                 810                 815     


Ser Arg Tyr Gln Asn Glu Lys Thr Lys Tyr Leu Asp Arg Leu Leu Gln 
            820                 825                 830         


Ser His Lys Tyr Ser Asp Thr Tyr Phe Leu Arg Asn Ala His Arg Asn 
        835                 840                 845             


Met Met Ala Lys Thr Arg Ser Tyr Met Arg Asp Gln Lys Gly Gln Asp 
    850                 855                 860                 


Gly Thr Leu Ile Glu Gly Leu Ala His Arg Tyr Arg Lys Thr Leu Gln 
865                 870                 875                 880 


Leu Pro Asp Gly Leu Phe Thr Asn Ala Ile Arg Glu Gln Leu Ala Lys 
                885                 890                 895     


Ile Asn Asn Ser Asp Ile Gln Asp Ala Leu Asn Asn Pro Gln Phe Gly 
            900                 905                 910         


His Ser Ala Ala Tyr Leu Leu Asn Leu Trp Phe Thr Lys Ile Ile Gly 
        915                 920                 925             


Asp Gln Ser Gln Pro Phe Tyr Arg Ser Asp Thr His Gly His Tyr Lys 
    930                 935                 940                 


Arg His Tyr Lys Leu Leu Glu Thr Leu Tyr Pro Gln Lys Thr Pro Leu 
945                 950                 955                 960 


Asp Asp Ala Thr Leu Ser Ala Lys Leu Lys Gly Gly Lys Asn Ser Glu 
                965                 970                 975     


Ile Lys Gln Glu Ile Asp Lys Gln Ala Pro Val Ala Lys Lys Glu Ala 
            980                 985                 990         


Glu His Gln Lys Leu Met His Leu  Leu Arg Asp Leu Gln  Arg Asn Glu 
        995                 1000                 1005             


Arg Thr  Ile Arg Arg Tyr Arg  Asn Gln Asp Met Val  Leu Phe Leu 
    1010                 1015                 1020             


Met Ala  Lys Lys Leu Leu Leu  Ser Gly Gly Ala Pro  Phe Met Asn 
    1025                 1030                 1035             


Arg Ala  Glu Ser Asp Gly Ser  Arg Gln Phe Leu Leu  Gln Asn Ile 
    1040                 1045                 1050             


Val Pro  Ile Gly Val Asn His  Gly Glu Glu Asn Asn  Leu Leu Asn 
    1055                 1060                 1065             


Gln Lys  Val Ser Leu Ser Thr  Arg Ile Thr Leu Leu  Asp Asp Lys 
    1070                 1075                 1080             


Asn Lys  Pro Ile Lys Asp Ser  Glu Lys His Pro Met  Lys Arg Thr 
    1085                 1090                 1095             


Ile His  Gln Lys Glu Ile Lys  Met Lys Asn Tyr Gly  Asp Phe Phe 
    1100                 1105                 1110             


Arg Phe  Leu Tyr Asp Ser Arg  Ile Gly Ile Leu Leu  Ser Gln Leu 
    1115                 1120                 1125             


Pro Asp  Asp Glu Ala Gly Ile  Ala Arg Glu Lys Leu  Glu Lys Glu 
    1130                 1135                 1140             


Leu Asp  Thr Tyr Asp Asn Ser  Arg Thr Asp Ile Phe  Lys Val Ile 
    1145                 1150                 1155             


His Lys  Ile Glu Arg Gln Ile  Ile Glu Glu His Pro  Glu Leu Lys 
    1160                 1165                 1170             


Asn Pro  Asn Ser Gly His Phe  Thr Asn Asp Lys Gly  Thr Pro Tyr 
    1175                 1180                 1185             


Arg Asn  Asn Phe Thr Leu Leu  Leu Thr Leu Ser Ala  Leu Phe Ser 
    1190                 1195                 1200             


Glu Ala  Asp His Asn Leu Asn  Gln Lys Gly Lys Leu  Leu Lys Asp 
    1205                 1210                 1215             


Ile Arg  Asp Ala Phe Cys His  Asn Lys Tyr Ile Glu  Asn Ile Glu 
    1220                 1225                 1230             


Arg Ala  Ile Lys Glu Lys Glu  Glu Arg Glu Leu Pro  Lys Ile Ala 
    1235                 1240                 1245             


Glu Asn  Leu Thr Lys Trp Met  Lys Glu Phe Gly Glu  Gln Ser 
    1250                 1255                 1260         


<210>  1736
<211>  1107
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1736

Met Asn Ile Pro Lys Leu Val Glu Asp Lys Lys Arg Tyr Phe Gly Thr 
1               5                   10                  15      


Tyr Thr Val Met Ala Leu Met Asn Ala Gln Thr Val Leu Asp His Ile 
            20                  25                  30          


Gln Lys Val Thr Glu Leu Pro Ile Ile Pro Ala Ile Asn Lys Glu Gly 
        35                  40                  45              


Lys Glu Phe Thr Pro Pro Glu Glu Asp Leu Trp Gln His Pro Val Met 
    50                  55                  60                  


Arg Tyr Ile Asn His Val Ala Tyr Lys Gln Asp Asp Gln Pro Glu Lys 
65                  70                  75                  80  


Thr Gln Ala Val Ile Glu Lys Leu Leu His His Phe Ser Phe Leu Lys 
                85                  90                  95      


Ile Met Ala Glu Asn Gln Arg Asp Tyr Trp Asn Lys Lys Asn Asn Thr 
            100                 105                 110         


His Arg Leu Glu Val Asn Ser Thr Asp Leu Asn Gly Ile Leu Asn Thr 
        115                 120                 125             


Val Phe Arg Val Ile Lys Lys Tyr Arg Asp Thr Thr Thr His Tyr Met 
    130                 135                 140                 


Thr Asn Asp Thr Cys Trp Asn Asp Gly Ser Asp Phe Leu Ala Lys Glu 
145                 150                 155                 160 


Gln Arg Leu Ala Phe Met Ile Asp Asn Tyr Tyr Glu Val Ala Leu Arg 
                165                 170                 175     


Asp Leu Lys Glu Arg Tyr Ser Tyr Thr Thr Asp Asp Leu Arg Phe Ile 
            180                 185                 190         


Gln Tyr Tyr Arg Tyr Lys Arg Val Arg Met Pro Asp Gly Lys Pro Thr 
        195                 200                 205             


Met Cys Lys Asn Thr Asn Phe Tyr Leu Ser Met Val Asp Tyr Asn Gly 
    210                 215                 220                 


Asp Ala Gly Lys Lys Leu His Leu Ser Gly Val Gly Val Ala Gln Leu 
225                 230                 235                 240 


Val Cys Leu Phe Leu Asp Lys Gln Tyr Ile Asn Gln Leu Ala Ser Asn 
                245                 250                 255     


Leu Glu Leu Thr Ser Lys His Leu Pro Ser Ser Lys Glu Ala Gln Ile 
            260                 265                 270         


Ile Arg Arg Ser Leu Gly Ile His Asn Ile Val Leu Pro Lys Asp Arg 
        275                 280                 285             


Ile His Ser Asp Lys Gly Glu Met Ser Ile Ala Met Asp Met Leu Gly 
    290                 295                 300                 


Glu Ile Lys Arg Cys Pro Asn Glu Leu Phe Asp Thr Leu Ser Ala Asp 
305                 310                 315                 320 


Arg Gln Ser Ser Phe Arg Leu Ile Ser Ser Asp His Asn Glu Val Leu 
                325                 330                 335     


Leu Lys Arg Ser Ser Asp Arg Phe Ala Gln Leu Thr Leu Gln Tyr Ile 
            340                 345                 350         


Asp Tyr Gly Glu Lys Phe Asp Arg Ile Arg Phe His Val Asn Met Gly 
        355                 360                 365             


Lys Leu Arg Tyr Leu Phe Asn Ala Glu Lys Thr Cys Val Asp Gly Gln 
    370                 375                 380                 


Val Arg Val Arg Val Ile Glu His Pro Leu Asn Gly Phe Gly Arg Met 
385                 390                 395                 400 


Ala Glu Met Glu Ala Met Arg Lys Gln Glu Asp Gly Thr Phe Gly Lys 
                405                 410                 415     


Thr Gly Ile Gln Ile Arg Asp Phe Asp Asn Val Lys Arg Asp Asp Ala 
            420                 425                 430         


Asn Pro Ala Asn Tyr Pro Tyr Ile Val Asp Thr Tyr Thr His Tyr Met 
        435                 440                 445             


Leu Asp Asp Asn His Val Glu Met Leu Ile Gly Lys Pro Met Asp Met 
    450                 455                 460                 


Pro Glu Ile Glu Glu Tyr Asp Gly Lys Trp Tyr Val Asn Lys Thr Val 
465                 470                 475                 480 


Pro Ser Cys Arg Met Ser Thr Leu Glu Leu Pro Ala Met Met Phe His 
                485                 490                 495     


Met His Leu Leu Gly Ser Lys Arg Thr Glu Ala Arg Ile Ile Asp Phe 
            500                 505                 510         


Tyr Glu Arg Tyr Cys Lys Leu Phe Asp Ala Leu Lys Gln Gly Ala Val 
        515                 520                 525             


Ser Lys Glu Asn Ile Gly Glu Phe Gly Ile Lys Glu Gln Asp Met Pro 
    530                 535                 540                 


Gln Thr Val Leu Asp Val Ile Asn Gly Asn Ala Gln Gly Lys Asn Ala 
545                 550                 555                 560 


Asn Glu Tyr Ile Leu Lys Thr Leu Gln Glu Leu Tyr Asp His Ala Cys 
                565                 570                 575     


Lys Arg Ile Asp Asn Leu Arg Gln Asp Lys Arg Ala Ile Gly Ser Ala 
            580                 585                 590         


Ala Asn Lys Met Gly Lys Arg Gly Tyr Arg Gln Ile Lys Pro Gly Lys 
        595                 600                 605             


Leu Ala Glu Tyr Leu Ile Gln Asp Ile Val Arg Trp Gln Pro Thr Leu 
    610                 615                 620                 


Ser Ala Gly Asp Asp Tyr Gly Thr Asp Arg Leu Thr Gly Leu Asn Tyr 
625                 630                 635                 640 


Arg Val Met Gln Ala Ala Ile Ala Thr Tyr Asp Ser Arg Gly Lys Asp 
                645                 650                 655     


Glu Glu Ala Arg Arg Phe Lys Ala Met Phe Glu Arg Ala Asn Leu Ile 
            660                 665                 670         


Gly Gly Asp Arg Gln Lys Asn His Pro Phe Leu Tyr Lys Val Phe Gly 
        675                 680                 685             


Tyr Arg Leu Pro Ala Asp Ile Val Asp Phe Tyr Glu Lys Tyr Leu Asn 
    690                 695                 700                 


Glu Gln Lys Tyr Tyr Ile Asn Ser Leu Leu Lys Lys Ala Lys Gln Gly 
705                 710                 715                 720 


Glu Val Val Asn Val Pro Phe Val Asn Arg Asp Gln Ser Lys Trp Lys 
                725                 730                 735     


Lys Pro Thr Gln Glu Tyr Leu Gly Ala Glu Tyr Met Ala Asp Lys Ala 
            740                 745                 750         


Ile Glu Leu Pro Arg Gln Met Phe Asp Glu Asp Ile Lys Asn His Leu 
        755                 760                 765             


Lys Thr Leu Asp Gln Met Lys Asp Val Asp Phe Asp His Ala Asn Val 
    770                 775                 780                 


Thr Tyr Leu Ile Gly Glu Tyr Met Lys Arg Val Arg Asp Asp Ala Phe 
785                 790                 795                 800 


Gln Glu Phe Tyr Ala Trp Arg Arg Asn Tyr Arg Tyr Ile Asp Leu Leu 
                805                 810                 815     


Lys Cys Glu Val Asp Arg Thr Lys Arg Ile Pro Lys Leu Val Glu Thr 
            820                 825                 830         


Trp Thr Thr Thr Glu Glu Arg Glu Lys Ile Trp Lys Glu Arg Glu Lys 
        835                 840                 845             


Leu Ala Lys Glu Tyr Arg Ser Trp Ala Asp Gly Gln Met Lys Asn Asn 
    850                 855                 860                 


Pro Gln Thr Arg Arg Leu Thr Glu Asp Glu Arg Gly Glu Ile Ile Ala 
865                 870                 875                 880 


Lys Arg Leu Ser Asn Ser Arg Asn Asp Tyr Gln Arg Ser Glu Lys Met 
                885                 890                 895     


Ile Arg Arg Tyr Lys Val Gln Asp Ala Leu Leu Phe Ile Ala Ala Asn 
            900                 905                 910         


Asp Thr Leu Thr Gln His Met Asp Phe Lys Gly Lys Gln Phe Lys Leu 
        915                 920                 925             


Lys Asp Ile Thr Pro Asp Ala Glu Arg Gly Ile Leu Ser Glu Lys Met 
    930                 935                 940                 


Ser Met Asp Phe Lys Phe Glu Lys Asn Gly Lys Thr Tyr Ile Ile Tyr 
945                 950                 955                 960 


Ala Gln Glu Met Lys Ile Lys Asn Tyr Gly Asp Phe Phe Val Leu Ala 
                965                 970                 975     


Asn Asp Lys Arg Leu Val Asn Leu Leu Ala Leu Val Asn Gln Asp Arg 
            980                 985                 990         


Val Ser Lys Asp Glu Ile Glu Gln  Glu Leu Lys Arg Tyr  Asp Val Cys 
        995                 1000                 1005             


Arg Pro  Glu Val Val Lys Met  Ile Leu Asp Leu Glu  Lys Trp Ala 
    1010                 1015                 1020             


Phe Asp  Asn Phe Pro Glu Leu  Lys Ala Lys Val Met  Asn Asp Arg 
    1025                 1030                 1035             


Glu Asp  Asn Lys Val Gly Phe  Asn Tyr Ile Leu Asp  Val Leu Leu 
    1040                 1045                 1050             


Glu Asn  Lys Arg Ile Gly Glu  Ala Gln Lys Glu Thr  Leu Arg Leu 
    1055                 1060                 1065             


Ile Arg  Asn Ala Phe Asp His  Asn Asn Tyr Pro Arg  Thr Gly Val 
    1070                 1075                 1080             


Val Asn  Val Val Thr Leu Pro  Glu Ile Ala Glu Glu  Met Arg Asp 
    1085                 1090                 1095             


Leu Phe  Gly Glu Tyr Ala Arg  Ile Glu 
    1100                 1105         


<210>  1737
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1737

Met Asn Thr His Gln Glu Glu Leu Gln Ser Trp Ile Thr Arg Lys Arg 
1               5                   10                  15      


Leu Pro Asp Thr Glu Met Lys Lys Tyr Trp Ala Ala Tyr Met Asn Leu 
            20                  25                  30          


Ala Arg Leu Asn Phe Phe Lys Thr Leu Met Phe Ile Ser Asn Ser Ile 
        35                  40                  45              


Gly Asp Leu Lys Pro Ala Lys Asp Asn Asn Gly Lys Gly Asn Thr Glu 
    50                  55                  60                  


Val Asn Met His Asn Met Gly Ile Leu Thr Ala Leu Leu Gly Pro Glu 
65                  70                  75                  80  


Asp Glu Glu Lys Ala Arg Leu Leu Ile Phe Lys His Phe Pro Phe Leu 
                85                  90                  95      


Arg Thr Phe Cys Ile Glu Lys Glu Leu Ser Leu Ser Lys Gln Arg Thr 
            100                 105                 110         


Ile Leu Ile Asp Met Ala Cys Ile Ile Gly Arg Tyr Arg Asn Met Tyr 
        115                 120                 125             


Ser His Ser Ile Phe Ile Ser Asp Asp Asn Glu Lys Val Leu Glu Ser 
    130                 135                 140                 


Glu Lys Arg Cys Ser Glu Tyr Leu Gln Ser Ile Leu Thr Val Ser Thr 
145                 150                 155                 160 


Arg Ile Ile Lys Glu Arg Tyr Arg Ser Asn Lys Asn Asp Ala Gln Arg 
                165                 170                 175     


Gly Met Ile Asp Asp Lys Ser Leu Glu Phe Ile Ser Glu Asn Lys Val 
            180                 185                 190         


Lys Phe Val Tyr Asp Glu Asn Gly Lys Arg Ile Thr Ala Pro Asn Lys 
        195                 200                 205             


Lys Tyr Tyr Leu Ser Thr Ile Asp Lys Asp Asn Thr His Leu Ser Tyr 
    210                 215                 220                 


Phe Gly Lys Leu Met Leu Thr Cys Ile Leu Leu Glu Lys Lys Tyr Ala 
225                 230                 235                 240 


Thr Ala Phe Leu Thr Gln Cys His Phe Leu Asp Ala Phe Asn Asp Ser 
                245                 250                 255     


Glu Val Ala Pro Lys Leu Ser Glu Arg Arg Leu Met Leu Glu Val Met 
            260                 265                 270         


Thr Ala Leu Arg Ile Arg Leu Ala Glu Lys Lys Leu Ser Asn Glu Lys 
        275                 280                 285             


Ser Glu Val Gln Ile Ser Leu Asp Ile Leu Asn Glu Leu Lys Lys Cys 
    290                 295                 300                 


Pro Phe Glu Leu Tyr Glu Leu Leu Gly Ser Glu Asp Lys Arg Leu Phe 
305                 310                 315                 320 


Thr Ile Val Ala Asp Thr Gly Glu Thr Ile Leu Leu Arg Arg His Glu 
                325                 330                 335     


Asp Arg Phe Pro Gln Leu Ala Leu Ser Trp Ile Asp Ser Ser Lys Ala 
            340                 345                 350         


Phe Asp His Leu Arg Phe Gln Val Asn Ala Gly Lys Leu Arg Tyr Leu 
        355                 360                 365             


Phe Arg Asp Asn Lys His Cys Ile Asp Gly Gln Thr Arg Met Arg Val 
    370                 375                 380                 


Leu Glu Glu Pro Leu Asn Gly Tyr Arg Arg Leu Met Glu Phe Glu Glu 
385                 390                 395                 400 


Glu Arg Ile Gln Lys Gln Ser Gly Glu Ile Arg Ser Leu Trp Pro Gly 
                405                 410                 415     


Leu Asp Ile Leu Asn Lys Asp Glu Thr Pro Arg Asn Asp Ala Ser Val 
            420                 425                 430         


Leu Pro Tyr Ile Ser Asp Tyr Arg Val Arg Tyr Leu Phe Asp Gly Asp 
        435                 440                 445             


Asn Ile Gly Ile Ser Ile Gly Asp Phe Thr Pro Ser Ile Thr Lys Thr 
    450                 455                 460                 


Asp Glu Thr Lys Tyr Arg Val Thr Gly Lys Thr Ala Asp Cys Cys Leu 
465                 470                 475                 480 


Ser Lys Tyr Glu Leu Pro Gly Leu Leu Phe Tyr His Leu Leu Thr Leu 
                485                 490                 495     


Arg His Gly Asp Asn Lys Arg Ser Thr Lys Asn Ala Glu Asp Ile Ile 
            500                 505                 510         


Ile Asp Ala Ile Lys Arg Tyr Lys Arg Leu Phe Ser Asp Val Lys Glu 
        515                 520                 525             


Gly Ile Leu Lys Pro Ile Lys Glu Glu Asn Ala Asn Gln Leu Gly Asn 
    530                 535                 540                 


Arg Ile Trp Asn Ser Tyr Gly Ile Asp Ile Lys Asp Ile Pro Asp Lys 
545                 550                 555                 560 


Ile Ile Asp Tyr Leu Leu Val Arg Glu Cys Asn Glu Asp Glu Lys Phe 
                565                 570                 575     


Thr Ala Trp Lys Asn Gly Leu Ile Ser Glu Met Leu Gln Ser Thr Lys 
            580                 585                 590         


Asn Arg Ile Lys Arg Phe Glu Lys Asp Ser Glu Ala Val Ile Ser Ser 
        595                 600                 605             


Asp Asn Lys Pro Gly Lys Lys Asn His Val Ser Leu Lys Pro Gly Ala 
    610                 615                 620                 


Tyr Ala Ser Phe Ile Ala Asn Asp Ile Val Phe Phe Gln Glu Cys Gly 
625                 630                 635                 640 


Ala Thr Glu Lys Met Thr Gly Leu Asn Phe Lys Val Met Gln Ser Arg 
                645                 650                 655     


Leu Ala Thr Phe Thr Lys Asp Gly Ser Thr Ser Phe Asn Ile Leu Leu 
            660                 665                 670         


Gln Thr Leu Lys Asn Ala His Leu Val Ser Asn Thr Tyr Gly Lys Gly 
        675                 680                 685             


Asp His Pro Phe Leu Tyr Arg Val Ile Lys Gln Gln Pro Ser Asp Ile 
    690                 695                 700                 


Val Gln Phe Tyr Lys Ile Tyr Leu Asn Glu Lys Val Leu Tyr Leu Gln 
705                 710                 715                 720 


Ser Asp Ile Pro Asp Asn Ala Ile Phe Leu His Gly Glu Arg Lys Arg 
                725                 730                 735     


Trp Glu Asn Arg Asn Glu Gln Tyr Tyr Arg Asp Leu Ala Glu Arg Tyr 
            740                 745                 750         


Leu Gln Arg Pro Ile Gln Leu Pro Arg Gln Leu Phe Glu Ser His Ile 
        755                 760                 765             


Arg Gln Leu Leu Leu Ser Asp Cys Ile Lys Gly Glu Arg Gly Asn Asp 
    770                 775                 780                 


Leu Lys Glu Ala Ile Asn Ser Ala Ala Ser Gln Gly Arg Cys Asn Thr 
785                 790                 795                 800 


Thr Tyr Met Ile Met Glu Tyr Phe Ala Asp Tyr Leu Cys Asp Gly Thr 
                805                 810                 815     


Gln Phe Phe Tyr Gly Leu Phe Asp Gly Asp Leu Ser His Glu Tyr Asn 
            820                 825                 830         


Tyr Arg Phe Tyr Ser Leu Ile Ser Asn Asn Ile Glu Asn Ser Lys Lys 
        835                 840                 845             


Leu Val Leu Thr Leu Lys Lys Gly Asn Asn Ser Lys Glu Ser Pro Phe 
    850                 855                 860                 


Ile Ser Ala Leu Glu Arg Gly Ile His Trp Ser Lys Met Asn Pro Leu 
865                 870                 875                 880 


Met Lys Lys Gly Leu Lys Asn Asp Ser Ser Glu Gly Asp Phe Val His 
                885                 890                 895     


Ala Ala Lys Arg Ala Tyr Lys Glu Met Thr Glu Thr Glu Arg Met Phe 
            900                 905                 910         


Arg Arg Tyr Ala Val Gln Asp Glu Val Leu Phe Leu Ala Ala Lys Ile 
        915                 920                 925             


Thr Ile Arg Arg Ala Leu Gly Leu Ser Glu Gln Tyr Asn Cys Leu Leu 
    930                 935                 940                 


Gly Asp Ile Lys Pro Gln Gly Gly Ser Leu Leu Glu Gln Thr Ile Pro 
945                 950                 955                 960 


Ser Ile Thr Thr Lys His Thr Ile Asn Thr Gly Asn Lys Lys Gln Lys 
                965                 970                 975     


Pro Lys Gln Val Gln Ile Leu Gln Lys Asn Val Lys Leu Lys Asp Phe 
            980                 985                 990         


Gly Lys Val Phe Lys Leu Leu Asn  Asp Arg Arg Ile Phe  Asp Leu Leu 
        995                 1000                 1005             


Phe Asn  Lys Gly Asn Glu Ala  Val Ser Met Thr Asp  Leu Cys Glu 
    1010                 1015                 1020             


Glu Leu  Glu Arg Tyr Asp Arg  His Arg Val Asp Val  Phe Asp Ser 
    1025                 1030                 1035             


Val Leu  Lys Tyr Glu Ser Lys  Ile Thr Lys Gly Tyr  Thr Asn Lys 
    1040                 1045                 1050             


Glu Leu  Met Asn Glu Ser Gly  Gln Ile Asp Phe Lys  Ala Ile Gln 
    1055                 1060                 1065             


Ala Phe  Asp Lys Gln Asn Thr  Thr Ser Asp Lys Glu  Asp Leu Arg 
    1070                 1075                 1080             


Leu Ile  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Gln Tyr Asn 
    1085                 1090                 1095             


Asn Glu  Pro Ile Leu Phe Asp  Lys Asp Ile Pro Glu  Ile Ala Asp 
    1100                 1105                 1110             


Glu Ile  Ser Ile Ile Ala Lys  Asp Ile Glu Glu Asn  Thr Lys 
    1115                 1120                 1125         


<210>  1738
<211>  1081
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1738

Met Gln Ala Gln Ser Leu Phe Asp Glu Tyr Lys His Leu Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Val Met Ser Ile Met Asn Ile Ile Thr Val Leu Asn His Ile 
            20                  25                  30          


His Gln Ile Ala Gly Leu Lys Arg Asn Glu Leu Gly Asp Asp Asp Asn 
        35                  40                  45              


Ile Tyr Ser His Pro Val Leu Lys Tyr Ile Ala Pro Glu Asn Asn Ser 
    50                  55                  60                  


Thr Thr Leu Pro Glu Lys Arg Asp Leu Ile Lys Glu Leu Leu Leu Glu 
65                  70                  75                  80  


Tyr Leu Pro Phe Leu Glu Ala Met Lys Asp Cys Tyr Lys Glu Val Lys 
                85                  90                  95      


Val Glu Lys Asp Lys Arg Asn Asn Lys Tyr Val Lys Asp Lys Lys Gln 
            100                 105                 110         


Val Phe Ile Arg Asn Tyr Ser Asp Ile Tyr Cys Ile Tyr Trp Thr Leu 
        115                 120                 125             


Tyr Asn Ile Phe Ser Thr Leu Ile Asn Tyr Arg Asp Lys Ser Cys His 
    130                 135                 140                 


Tyr Arg Phe Ile Pro Ser Lys Asp Gln Glu Glu Tyr Ser Lys Arg Thr 
145                 150                 155                 160 


Glu Tyr Asp Thr Val Arg Ile Ile Asn Lys Tyr Tyr Thr Tyr Ala Leu 
                165                 170                 175     


Arg Lys Thr Lys Glu Lys Tyr Gly Tyr Thr Thr Glu Gln Leu Ser Phe 
            180                 185                 190         


Ile Gln Asn Asn Arg Tyr Thr Asp Asp Lys Lys Val Asn Phe Asn Phe 
        195                 200                 205             


Phe Leu Ser Met Gln Ser Ser Asn Asn Asn Leu Ser His Val Gly Val 
    210                 215                 220                 


Ala Gln Leu Ile Cys Leu Phe Leu Gln Lys Lys Asp Val Asp Asn Phe 
225                 230                 235                 240 


Leu Glu Asn Leu Pro Ile Tyr Asp Asn Arg Tyr Cys Leu Gly Ile Asp 
                245                 250                 255     


Glu His Met Ile Ile Lys Arg Ser Leu Ala Leu His Ser Ile Lys Leu 
            260                 265                 270         


Pro Lys Glu Arg Leu Asn Ser Glu Lys Lys Asp Met Ala Ile Ala Met 
        275                 280                 285             


Asp Met Leu Asn Glu Leu Lys Arg Cys Pro Lys Glu Leu Phe Asn Thr 
    290                 295                 300                 


Leu Pro Phe Asp Lys Gln Glu Arg Phe Arg Ile Ile Ser Ser Asp His 
305                 310                 315                 320 


Lys Glu Val Leu Leu Met Arg Ser Thr Asp Arg Phe Val Pro Leu Ile 
                325                 330                 335     


Leu Gln Tyr Ile Asp Cys Asn Lys Lys Phe Lys Asp Ile Arg Phe His 
            340                 345                 350         


Val Asn Met Gly Lys Leu Arg Tyr Leu Phe Ser Pro Asn Lys Leu Cys 
        355                 360                 365             


Ile Asp Asn Gln Glu Arg Val Arg Met Leu Glu His Leu Leu Asn Gly 
    370                 375                 380                 


Tyr Gly Arg Ile Asp Glu Val Glu Tyr Leu Arg Lys Ala Pro Asn Gly 
385                 390                 395                 400 


Thr Phe Gly Asn Thr Asn Ile Pro Ile Lys Gly Phe Gly Glu Ile Glu 
                405                 410                 415     


Arg Asp Ser Ala Asp Ser Asn Asn Tyr Pro Tyr Ile Val Asp Thr His 
            420                 425                 430         


Thr His Tyr Ile Leu Asn Asn Asn Lys Val Glu Phe Cys Phe Cys Glu 
        435                 440                 445             


Asp Ser Lys Asn Lys Asn Val Phe Pro Thr Ile Glu Lys Glu Ile Asn 
    450                 455                 460                 


Gly Lys Trp Tyr Val Glu Lys Thr Ala Pro His Cys Arg Ile Ser Phe 
465                 470                 475                 480 


Phe Glu Ile Pro Ala Met Ala Phe His Met Phe Leu Cys Gly Ser Glu 
                485                 490                 495     


Lys Thr Glu Lys Leu Ile Lys Asp Val Tyr Asn Asn Tyr Ile Ser Leu 
            500                 505                 510         


Phe Asn Ala Leu Lys Asn Gly Ala Leu Thr Glu Glu Asn Tyr Lys Asp 
        515                 520                 525             


Phe Asn Ile Pro Glu Cys Asp Met Pro Lys Lys Ile Leu Asp Phe Leu 
    530                 535                 540                 


Lys Gly Lys Ala Glu Gly Lys Ser Ile Asp Gly Tyr Val Lys Asn Ile 
545                 550                 555                 560 


Leu Lys Lys Glu Leu Lys Asp Thr Arg Lys Arg Ile Glu Gln Ala Pro 
                565                 570                 575     


Ser Glu Lys Asp Gln Met Pro Ser Lys Arg Asn Lys Ile Gly Thr Lys 
            580                 585                 590         


Ser Tyr Lys Arg Val Leu Thr Gly Lys Leu Ala Asp Phe Leu Ala Lys 
        595                 600                 605             


Asp Ile Val Lys Tyr Gln Pro Thr Leu Cys Ala Gly Asp Asp Tyr Gly 
    610                 615                 620                 


Ile Asp Arg Met Thr Gly Met Asn Tyr Arg Ile Met Gln Ala Thr Ile 
625                 630                 635                 640 


Ala Thr Tyr Asn Asp Asp Asp Asp Phe Asp Thr Phe Tyr Asn Val Phe 
                645                 650                 655     


Lys Met Ala Gly Leu Val Asp Gly Asp Glu Arg Lys Asn His Pro Phe 
            660                 665                 670         


Leu Lys Lys Val Leu Leu Ser Lys Pro Gln Asn Thr Val Ala Phe Asn 
        675                 680                 685             


Ile Lys Tyr Leu Lys Glu Lys Glu Ile Tyr Leu Arg Asn Ile Glu Lys 
    690                 695                 700                 


Lys Asn Ile Ile Pro Pro Phe Val Asn Arg Glu Arg Asn Lys Trp Cys 
705                 710                 715                 720 


Glu Arg Asp Cys Glu Tyr Tyr Arg Ile Leu Gly Glu Asn Leu Leu Asp 
                725                 730                 735     


Leu Pro Ile Glu Leu Pro Arg Gln Met Phe Tyr Lys Asp Ile Arg Ala 
            740                 745                 750         


Gln Leu Glu Pro Leu Met Pro Glu Ile Asp Phe Ser Gln Thr Asn Thr 
        755                 760                 765             


Thr Tyr Leu Ile Ala Glu Tyr Leu Lys Arg Val Arg Gly Asp Asp Phe 
    770                 775                 780                 


Gln Glu Phe Tyr Ser Trp Glu Arg Asn Tyr Arg Tyr Ile Asp Phe Leu 
785                 790                 795                 800 


Lys Cys Ile Arg Asp Asp Asn Gly Arg Ile Cys Ala Gln Tyr Thr Thr 
                805                 810                 815     


Thr Glu Glu Arg Glu Ser Leu Trp Glu Asp Ser Lys Asn Arg Thr Ala 
            820                 825                 830         


Glu Tyr Lys Arg Ser Glu Glu Gln Lys Asn Glu Lys Lys Asp Lys Asn 
        835                 840                 845             


Phe Glu Asp Ser Leu Glu Glu Arg Ile Ser Ser Ser His Ile Lys Phe 
    850                 855                 860                 


Gln Asn Thr Glu Lys His Ile Arg Arg Tyr Lys Val Gln Asp Ala Leu 
865                 870                 875                 880 


Leu Phe Met Ile Ala Glu Lys Gln Phe Gly Lys Tyr Leu Asp Asp Ile 
                885                 890                 895     


Lys Ala Lys Asn Phe Lys Leu Lys Asp Ile Met Pro Asp Thr Asp Lys 
            900                 905                 910         


Gly Ile Leu Ser Glu Thr Met Pro Ile Asp Phe Thr Phe Thr Lys Lys 
        915                 920                 925             


Asn Ile Lys Tyr Asn Ile His Ala Lys Asn Leu Lys Phe Lys Glu Tyr 
    930                 935                 940                 


Gly Asp Leu Phe Ile Leu Ala Asn Asp Lys Arg Leu Glu Ser Leu Trp 
945                 950                 955                 960 


Lys Ile Leu Ala Thr Asp Thr Val Asn Lys Glu Glu Ile Ser Glu Glu 
                965                 970                 975     


Phe Ala Lys Tyr Asp Phe Cys Arg Pro Asp Ile Thr Lys Leu Val Leu 
            980                 985                 990         


Asp Phe Glu Lys Asp Val Leu Glu  Lys Tyr Pro Glu Ile  Ile Glu Glu 
        995                 1000                 1005             


Ala Glu  Lys Glu Tyr Lys Lys  Phe Asp Phe Lys Phe  Ile Leu Asp 
    1010                 1015                 1020             


Trp Leu  Ile Asn Lys Lys Lys  Leu Asn Tyr Gly Ile  Arg Asn Lys 
    1025                 1030                 1035             


Leu Leu  Leu Ile Arg Asn Ala  Phe Asn His Asn Ser  Tyr Pro Asp 
    1040                 1045                 1050             


Lys Lys  Tyr Ala Glu Val Arg  Glu Leu Pro Glu Ile  Ala Thr Asn 
    1055                 1060                 1065             


Leu Lys  Lys Thr Phe Asp Glu  Asn Ala Lys Lys Tyr  Glu 
    1070                 1075                 1080     


<210>  1739
<211>  1000
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1739

Met Glu Glu Ala Asn Arg Tyr Ile Tyr Gly Ala Tyr Phe Asn Met Ala 
1               5                   10                  15      


Arg Asp Asn Phe Leu Asn Thr Ile Lys Leu Leu Ala Asp Lys Met Lys 
            20                  25                  30          


Leu Gly Ala Thr Ser Gly Phe Gly Lys Asp Gly Asn Glu Val Asn Asp 
        35                  40                  45              


Ile Asn Glu Leu Phe Gly Asp Lys Asn Thr Tyr Ala Asn Ile Glu Asn 
    50                  55                  60                  


Val Val Glu Phe Tyr Phe Pro Trp Ile Lys Ala Leu Glu Gly Arg Phe 
65                  70                  75                  80  


Ser Leu Asp Lys Gly Asp Arg Asn Leu Asn Asp Met Lys Met Phe Tyr 
                85                  90                  95      


Lys Ser Val Leu Thr Ala Phe Phe Thr Ala Val Asp Ser Leu Arg Asn 
            100                 105                 110         


Lys Tyr Thr His Tyr Ser His Lys Asp Leu Asn Ile Arg Glu Ile Lys 
        115                 120                 125             


Ile Glu Cys Thr Leu Gly Gly Lys Asp Tyr Cys Ile Gly Leu Leu Asn 
    130                 135                 140                 


Ala Leu Asp Cys Ile Tyr Asp Ser Ala Val Asn Leu Leu Lys Leu Arg 
145                 150                 155                 160 


Phe Met Ala Asp Glu Asp Glu Val Ala His Leu Arg Arg Cys Lys Ala 
                165                 170                 175     


Val Asn Lys Lys Val Val Val Arg Thr Glu Lys Asp Gly Phe Tyr Tyr 
            180                 185                 190         


Arg Leu Ser Asp Asn Gly Glu Val Thr Glu Lys Gly Val Ile Phe Ile 
        195                 200                 205             


Ala Ser Met Phe Leu Asn Arg Lys Tyr Gly Phe Leu Phe Leu Lys Gln 
    210                 215                 220                 


Leu Glu Gly Phe Lys Arg Ser Asp Glu Lys Arg Tyr Arg Leu Thr Leu 
225                 230                 235                 240 


Glu Ala Phe Leu Ala Phe Ser Asn Ile Lys Pro Val Asp Arg Leu Lys 
                245                 250                 255     


Ser Asp Lys Leu Asp Arg Ala Ser Leu Gly Leu Asp Met Leu Asn Glu 
            260                 265                 270         


Leu Thr Lys Ile Pro Lys Glu Leu Ser Glu Thr Leu Ser Val Asp Cys 
        275                 280                 285             


Leu Tyr Lys Tyr Leu Ala Ser Asp Gly Glu Asp Asp Leu Arg Ser Arg 
    290                 295                 300                 


Ile Arg Tyr Gln Asp Arg Phe Val Pro Leu Ala Leu Glu Phe Ile Ser 
305                 310                 315                 320 


Gln Ser Asp Glu Phe Lys Asp Phe Arg Phe Tyr Thr Tyr Val Gly Asn 
                325                 330                 335     


Tyr Val Tyr Lys Gly Tyr Ile Lys Arg Leu Ile Asp Gly Thr Asp Lys 
            340                 345                 350         


Glu Arg Tyr Leu Ser Asp Arg Leu Cys Gly Phe Tyr Lys Ser Val Asn 
        355                 360                 365             


Asp Ala Ser Ser Asp Ala Ile Ala Gln Lys Tyr Gly Val Glu Ile Lys 
    370                 375                 380                 


Asp Ser Asn Glu Pro Asp Tyr Met Leu Pro Asp Ser Phe Arg Pro His 
385                 390                 395                 400 


Val Leu Arg Ala Thr Pro His Phe Val Ile Asn Asn Asn Asn Ile Gly 
                405                 410                 415     


Ile Lys Ile Cys Gly Asn Asp Cys Leu Pro Val Val Asn Gly Lys Gly 
            420                 425                 430         


Val Glu Ser Pro Glu Pro Asp Tyr Trp Leu Ser Ile Tyr Glu Leu Pro 
        435                 440                 445             


Ala Met Leu Phe Tyr Ala Tyr Leu Arg Glu Lys Asn Gly Lys Leu Leu 
    450                 455                 460                 


Lys Asp Tyr Lys Ser Ile Arg Glu Leu Ile Glu Asp Val Glu Lys Lys 
465                 470                 475                 480 


Ala Asp Glu Lys Asn Asp Arg Asp Lys Gly Ala Leu Met Ala Arg His 
                485                 490                 495     


Ile Asp Lys Glu Ile Ile Trp Thr Gln Thr Lys Leu Asp Glu Val Lys 
            500                 505                 510         


Arg Leu Glu Glu Lys Lys Val Ala Ala Tyr Gly Lys Lys Gly Arg Val 
        515                 520                 525             


Val Leu Lys Ser Gly Arg Met Ala Asp Leu Leu Ala His Asp Met Val 
    530                 535                 540                 


Arg Leu Gln Pro Ala Thr Lys Gly Ser Asp Lys Ile Thr Gly Ala Asn 
545                 550                 555                 560 


Phe Gln Ala Leu Gln Val Ser Leu Ala Tyr Phe Lys Arg Asp Ile Leu 
                565                 570                 575     


Ala Asp Val Phe Ser Arg Ala Met Leu Thr Thr Gly Asn His Arg His 
            580                 585                 590         


Pro Phe Leu Tyr Arg Ile Asp Val Ser His Cys Ser Ser Leu Arg Asp 
        595                 600                 605             


Phe Tyr Val Ala Tyr Leu Gly Glu Arg Arg Lys Tyr Phe Glu Asp Val 
    610                 615                 620                 


Ala Lys Lys Ile Thr Lys Asn Lys Leu Asn Thr Pro Cys His Ile Leu 
625                 630                 635                 640 


Arg Arg Leu Gln Arg Glu Gly Ser Gly Glu Glu Ala Gly Lys Asp Val 
                645                 650                 655     


Lys Pro Lys Phe Leu Pro Arg Gly Ile Phe Thr Gly Ser Ile Lys Ser 
            660                 665                 670         


Cys Leu Glu Lys Ser Ala Leu Asn Ile Asn Ile Arg Asn Ala Arg Asn 
        675                 680                 685             


Asp Val Lys Pro Ala Ile Asn Ala Ala Tyr Leu Ile Phe Met Tyr Tyr 
    690                 695                 700                 


Lys Glu Ile Glu Lys Gly Glu Phe Gln Gly Phe Tyr Gly Glu Lys Arg 
705                 710                 715                 720 


Arg Tyr Asp Ile Leu Glu Glu Gly Lys Pro Leu Asp Leu Asp Glu Arg 
                725                 730                 735     


Lys Lys Ala Leu Ala Ser Ile Lys Pro Ala Lys Ile Asp Val Ser Glu 
            740                 745                 750         


Ala Asn Met Pro Met Ser Lys Glu Glu His Leu Met Arg Lys Arg Tyr 
        755                 760                 765             


His Ala Val Cys Asn Asn Glu Ser Ala Ile Arg Met Tyr Gln Val Gln 
    770                 775                 780                 


Asp Ile Leu Leu Leu Leu Met Ala Lys Asp Ile Phe Lys Lys Ala Leu 
785                 790                 795                 800 


Ser Glu Val Val Met Ser Lys Lys Ile Gly Leu Glu Asn Leu Asn Gly 
                805                 810                 815     


Ile Phe Asp Ala Pro Val Asn Phe Val Lys Asn Phe Asp Asn Ile Lys 
            820                 825                 830         


Leu Thr Ala Thr Gly Ile Lys Ile Lys Asp Tyr Gly Lys Val Cys Arg 
        835                 840                 845             


Leu Gly Thr Asp Phe Lys Phe Asn Ser Leu Ile Lys Ala Phe His Lys 
    850                 855                 860                 


Val Tyr Ser Lys Ser Val Glu Met Asp Tyr Ser Asp Tyr Leu Lys Glu 
865                 870                 875                 880 


Glu Glu Glu Phe Glu Lys Tyr Arg Leu Asn Met Val Lys Leu Cys Arg 
                885                 890                 895     


Glu Val Glu Arg Gly Ile Thr Glu Asp Leu His Leu Ser Leu Asp Gly 
            900                 905                 910         


Lys Ser His Leu Ser Phe Asn Asp Asp Val Ile Lys Ser Tyr Asn Asp 
        915                 920                 925             


Lys Tyr Asn Val Phe Asn Gly Asp Asp Leu Thr Phe Phe Ile Asn Ala 
    930                 935                 940                 


Arg Asn Met Phe Met His Gly Asp Tyr Lys Tyr Glu Cys Val Lys Tyr 
945                 950                 955                 960 


Val Val Ser Glu His Phe Lys Gly Ser Leu Asn Asp Val Ser Phe Ala 
                965                 970                 975     


Lys Glu Thr Tyr Gly His Phe Cys Asn Leu Leu Glu Ser Met Arg Lys 
            980                 985                 990         


Lys Thr Gly Leu Arg Ile Asp Ile  
        995                 1000 


<210>  1740
<211>  1196
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1740

Met Lys Arg Phe Ser Ser Leu Leu Arg Arg Glu Glu Ile Ser Ser Phe 
1               5                   10                  15      


Asp Leu Tyr Thr Asp Phe Gly Thr Lys Ser Pro Leu Leu Ala Ile Tyr 
            20                  25                  30          


Tyr Asn Val Ala Cys Val Asn Trp Glu Gln Thr Gln Lys Leu Ile Arg 
        35                  40                  45              


Gly Phe Pro Pro Asp Arg Gln Thr Ala Tyr Leu Ala Gln Tyr Leu Trp 
    50                  55                  60                  


Arg Ala Asn Leu Val Lys Arg Asn Ala Glu Gly Tyr Lys Phe Thr Glu 
65                  70                  75                  80  


Asp Asp Arg Arg Ile Ala Ala Leu Leu Pro Glu Lys Leu Asp Ala Ile 
                85                  90                  95      


Arg Asn Phe His Ser His Ile Trp His Asp Asn Ser Val Leu Gln Ala 
            100                 105                 110         


Asp Gly Asp Leu Lys Ala Phe Val Glu Lys Lys His Glu Glu Ala Lys 
        115                 120                 125             


Ala Arg Leu Phe Glu Gln Asn Pro Gln Ser Leu Leu Asp Tyr Glu Ala 
    130                 135                 140                 


Tyr Ala Lys Gly Lys Ser Lys Tyr Ala Leu Phe Lys Tyr Val Lys Asp 
145                 150                 155                 160 


Lys Arg Ala Asp Tyr Phe Thr Ile Glu Gly Arg Ile Phe Tyr Leu Ser 
                165                 170                 175     


Phe Phe Leu Thr Ala Gly Gln Met Asn Gln Leu Leu Gln Gln Cys Ser 
            180                 185                 190         


Gly Phe Lys Arg Ala Asp Met Pro Leu Phe Lys Ile Lys Arg Gln Leu 
        195                 200                 205             


Tyr Thr Tyr Tyr Cys His Arg Asp Gly Ala Thr Leu Leu Asp Phe Asn 
    210                 215                 220                 


His Asp Gln Glu Val Leu Ala Ser Met Pro Pro Val Glu Lys Gln Ala 
225                 230                 235                 240 


Ile Ile Arg Ala Arg Thr Ala Phe Lys Leu Val Asn Tyr Leu Tyr Asp 
                245                 250                 255     


Tyr Pro Glu Tyr Trp Gly Ser Ala Asp Trp Met Pro Leu Tyr Asp Glu 
            260                 265                 270         


Ala Gly Glu Arg Ile Asn Ser Gly Glu Ala Leu Lys Gln Trp Leu Asp 
        275                 280                 285             


Lys Asn Pro Asp Thr Leu Pro Gly Ile Ser Phe Ser Phe Ile Pro Ile 
    290                 295                 300                 


Lys Lys Ser Pro Ala Asp Ala Asp Lys Lys Glu His Glu Ser Arg Val 
305                 310                 315                 320 


Arg Ser Gly Thr Leu Ala Phe Thr Val Glu Gly Ile Glu Lys Tyr Glu 
                325                 330                 335     


Phe His Ile Thr Phe Pro Ala Leu His Arg Leu Val Val Leu Gln Arg 
            340                 345                 350         


Leu Tyr Gln Leu Lys Lys Glu Gly Val Ser Pro Leu Glu Leu Leu Lys 
        355                 360                 365             


Lys Asn Leu Gln Gln Gln Val Asp Asn Arg Ala Ser Leu Tyr Ala Ile 
    370                 375                 380                 


Leu Ser Lys Arg Glu Arg Leu Arg Thr Glu Asp Glu Trp Glu Tyr Leu 
385                 390                 395                 400 


Thr Asp Arg Ser His Gln Gln Leu Arg Gly Gly Arg Lys Leu Thr Glu 
                405                 410                 415     


Leu Ser Ile Thr Phe Phe Glu Asn Leu Thr Lys Gly Gly Ala Glu Asn 
            420                 425                 430         


Pro Val Val Thr Thr Arg Leu Leu Asn Leu Ile Arg Pro Ala Glu Ser 
        435                 440                 445             


Thr Pro Leu Pro Thr Pro Leu Asn Lys Leu Gly Lys Thr Arg Phe Thr 
    450                 455                 460                 


Asp Asp Thr Glu Pro Asp Ala Ile Gln Val Tyr Glu Gln Asp Tyr Ile 
465                 470                 475                 480 


Met Gly Ala Thr Gln Lys Phe Arg Ala Gly Asn Arg Phe Met Tyr Tyr 
                485                 490                 495     


Ser Ala Lys Tyr Leu Met Asp Phe Gly Gly Gln Asp Trp Arg Trp Gly 
            500                 505                 510         


Met Glu Lys Phe Ala Met Asp Lys Lys Lys Asn Ser Asp Thr Lys Glu 
        515                 520                 525             


Ser Leu Leu Lys Ile Lys Glu Tyr Leu Thr Pro Arg Glu Ile Leu Glu 
    530                 535                 540                 


Ser Asn Asp His Arg Leu Thr Leu Glu Glu Asp His Val Tyr Leu Ala 
545                 550                 555                 560 


Ile Pro Arg Pro Ala Pro Lys Gly Ser Ala Asn His Gln Gln Tyr Tyr 
                565                 570                 575     


Gln Phe Ala Ile Gly Pro Arg Ala Met Arg Tyr Leu Met Ala Trp Val 
            580                 585                 590         


Phe Glu Lys Arg Asp Lys Ser Pro Glu Glu Ile Ser Ser Phe Leu Met 
        595                 600                 605             


Glu Leu Ser Gln Asp Leu Glu Leu Leu Tyr Gln Glu Gly Ala Trp Asn 
    610                 615                 620                 


Ser Glu Leu Pro Val Lys Trp Leu Glu Pro Ala Phe Val Met Gly Tyr 
625                 630                 635                 640 


Leu Lys Glu Tyr Glu Thr Gly Gly Leu Asp Thr Val Arg Gln Arg Ile 
                645                 650                 655     


Gln Ser Arg Ile Ser His Ile Thr Lys Val Trp Asp His Ala Val Glu 
            660                 665                 670         


His Thr Gln Leu Leu Ser Arg Ser Glu Lys Asn Arg Leu Ile Met Glu 
        675                 680                 685             


Ala Tyr Arg Phe Tyr Glu Trp Pro Ala Gly Gly Asn Gly Val Pro Arg 
    690                 695                 700                 


Phe Leu Arg Ala Asp Glu Tyr Asn Gln Met Ser Val Cys His Tyr Ser 
705                 710                 715                 720 


Leu Gly Leu Lys Lys Lys Gln Gln Thr Val Phe Val His Lys Gly Arg 
                725                 730                 735     


Asn Tyr Asn Asn Lys Tyr Asp Tyr Val Tyr Lys Gly Leu Phe Glu Leu 
            740                 745                 750         


Asp Lys Arg Lys Pro Pro Ile Pro Lys Asp Val Glu Arg Gln Leu Gln 
        755                 760                 765             


Thr Ala Glu Asn Leu Asp Glu Leu Leu Val Asn Val Ile Thr Ser Ile 
    770                 775                 780                 


Arg Asp Leu Leu Asn Asp Lys Ile Lys Ser Ile Leu Gly Ala Pro Pro 
785                 790                 795                 800 


Ala Ile Gln Lys Lys Glu Leu Pro Gly Leu Cys Arg Arg Leu Gly Ile 
                805                 810                 815     


Ser Ile Pro Ala Ser Leu Leu Lys Gly Pro Glu Thr Glu Ser Met Arg 
            820                 825                 830         


Gln Lys His Leu Thr Thr Leu Gln Val Gln Pro Leu Ala Ile His Pro 
        835                 840                 845             


Met Leu Met Val Lys Lys Leu Phe Pro Gly Phe Tyr Ser Pro Ala Gln 
    850                 855                 860                 


Thr Asp Ser Gln Ser Gly Ser Thr Asp Lys Thr Leu Lys Arg Pro Asn 
865                 870                 875                 880 


Leu Pro Val Phe Asp Lys Leu Arg Lys Asn Ala Ser Tyr Arg Lys Arg 
                885                 890                 895     


Leu His Pro Asp Phe Tyr Asn Lys Glu Phe Ala Ser His Leu Phe Pro 
            900                 905                 910         


Glu Asp Gly Asn Lys Lys Gln Arg Glu Lys Leu Ile Gly Glu Met Asp 
        915                 920                 925             


Arg Thr Cys Ala Glu Asp Ile Leu Leu Trp Gln Met Ala His His Tyr 
    930                 935                 940                 


Leu Arg Asp Asn His Tyr Thr Glu Thr Leu Ala Gln His Leu Gln Gln 
945                 950                 955                 960 


Leu Glu Pro Gly His Gln Pro Leu Tyr Asp Trp Leu Lys Leu Pro Ile 
                965                 970                 975     


Val Ile Gln Leu Lys Pro Arg Asn Glu Gly Lys Asp Leu Tyr Ile Ser 
            980                 985                 990         


Ile Leu Leu His Gln Leu Asp Asp  Leu Leu Phe Arg Gln  Glu Arg Asp 
        995                 1000                 1005             


Arg Leu  Arg Lys Leu Ala Asp  His Phe Thr Tyr Arg  Ile Thr Gln 
    1010                 1015                 1020             


Glu Thr  Ala Leu Trp Glu Asp  Asp Leu Lys Asp Met  Gln Leu Asn 
    1025                 1030                 1035             


Gln Leu  Ser Val Gly Pro Leu  Pro Asp Gly Ser Arg  Gln Asn Pro 
    1040                 1045                 1050             


Ile Pro  Phe Gly Ile Leu Met  Ala Glu Ala Glu Leu  Ile Arg Arg 
    1055                 1060                 1065             


Cys Gly  Gln Gln Leu Ala Glu  Arg Leu Leu Asp Trp  Glu Thr Gly 
    1070                 1075                 1080             


Ile Phe  Glu Gln Leu Leu Ser  Val His Ala Asp Asp  Lys Gln Ser 
    1085                 1090                 1095             


Leu His  Asp Trp Leu Ser Gln  His Val Asp Gly Val  Asp Tyr Tyr 
    1100                 1105                 1110             


Arg Gln  Phe Lys Tyr Ala Phe  Met Asn Phe Asp Asp  Val Leu Ala 
    1115                 1120                 1125             


Val Ala  Val Ser Leu Gly Ile  Glu Ile Ser Glu Ile  Asp Ser Lys 
    1130                 1135                 1140             


Leu Met  Ser Ser Leu Arg Asn  Cys Thr Phe His Asn  Asp Ile Pro 
    1145                 1150                 1155             


Glu Ser  Gly Ser Tyr Ser Trp  Ile Thr Arg Ser Gly  Glu Arg Val 
    1160                 1165                 1170             


Arg Asn  Ile Leu Asn Met Glu  Thr Asp Leu His Ala  Arg Lys Asp 
    1175                 1180                 1185             


Arg Ser  Ala Tyr Glu Lys Lys  Asp 
    1190                 1195     


<210>  1741
<211>  1332
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1741

Met Leu Leu Lys Leu Lys Thr Tyr Ser Ile Met Ser Lys Glu Cys Lys 
1               5                   10                  15      


Lys Gln Arg Gln Glu Lys Lys Arg Arg Leu Gln Lys Ala Asn Phe Ser 
            20                  25                  30          


Ile Ser Leu Thr Gly Lys His Val Phe Gly Ala Tyr Phe Asn Met Ala 
        35                  40                  45              


Arg Thr Asn Phe Val Lys Thr Ile Asn Tyr Ile Leu Pro Ile Ala Gly 
    50                  55                  60                  


Val Arg Gly Asn Tyr Ser Glu Asn Gln Ile Asn Lys Met Leu His Ala 
65                  70                  75                  80  


Leu Phe Leu Ile Gln Ala Gly Arg Asn Glu Glu Leu Thr Thr Glu Gln 
                85                  90                  95      


Lys Gln Trp Glu Lys Lys Leu Arg Leu Asn Pro Glu Gln Gln Thr Lys 
            100                 105                 110         


Phe Gln Lys Leu Leu Phe Lys His Phe Pro Val Leu Gly Pro Met Met 
        115                 120                 125             


Ala Asp Val Ala Asp His Lys Ala Tyr Leu Asn Lys Lys Lys Ser Thr 
    130                 135                 140                 


Val Gln Thr Glu Asp Glu Thr Phe Ala Met Leu Lys Gly Val Ser Leu 
145                 150                 155                 160 


Ala Asp Cys Leu Asp Ile Ile Cys Leu Met Ala Asp Thr Leu Thr Glu 
                165                 170                 175     


Cys Arg Asn Phe Tyr Thr His Lys Asp Pro Tyr Asn Lys Pro Ser Gln 
            180                 185                 190         


Leu Ala Asp Gln Tyr Leu His Gln Glu Met Ile Ala Lys Lys Leu Asp 
        195                 200                 205             


Lys Val Val Val Ala Ser Arg Arg Ile Leu Lys Asp Arg Glu Gly Leu 
    210                 215                 220                 


Ser Val Asn Glu Val Glu Phe Leu Thr Gly Ile Asp His Leu His Gln 
225                 230                 235                 240 


Glu Val Leu Lys Asp Glu Phe Gly Asn Ala Lys Val Lys Asp Gly Lys 
                245                 250                 255     


Val Met Lys Thr Phe Val Glu Tyr Asp Asp Phe Tyr Phe Lys Ile Ser 
            260                 265                 270         


Gly Lys Arg Leu Val Asn Gly Tyr Thr Val Thr Thr Lys Asp Asp Lys 
        275                 280                 285             


Pro Val Asn Val Asn Thr Met Leu Pro Ala Leu Ser Asp Phe Gly Leu 
    290                 295                 300                 


Leu Tyr Phe Cys Val Leu Phe Leu Ser Lys Pro Tyr Ala Lys Leu Phe 
305                 310                 315                 320 


Ile Asp Glu Val Arg Leu Phe Glu Tyr Ser Pro Phe Asp Asp Lys Glu 
                325                 330                 335     


Asn Met Ile Met Ser Glu Met Leu Ser Ile Tyr Arg Ile Arg Thr Pro 
            340                 345                 350         


Arg Leu His Lys Ile Asp Ser His Asp Ser Lys Ala Thr Leu Ala Met 
        355                 360                 365             


Asp Ile Phe Gly Glu Leu Arg Arg Cys Pro Met Glu Leu Tyr Asn Leu 
    370                 375                 380                 


Leu Asp Lys Asn Ala Gly Gln Pro Phe Phe His Asp Glu Val Lys His 
385                 390                 395                 400 


Pro Asn Ser His Thr Pro Asp Val Ser Lys Arg Leu Arg Tyr Asp Asp 
                405                 410                 415     


Arg Phe Pro Thr Leu Ala Leu Arg Tyr Ile Asp Glu Thr Glu Leu Phe 
            420                 425                 430         


Lys Arg Ile Arg Phe Gln Leu Gln Leu Gly Ser Phe Arg Tyr Lys Phe 
        435                 440                 445             


Tyr Asp Lys Glu Asn Cys Ile Asp Gly Arg Val Arg Val Arg Arg Ile 
    450                 455                 460                 


Gln Lys Glu Ile Asn Gly Tyr Gly Arg Met Gln Glu Val Ala Asp Lys 
465                 470                 475                 480 


Arg Met Asp Lys Trp Gly Asp Leu Ile Gln Lys Arg Glu Glu Arg Ser 
                485                 490                 495     


Val Lys Leu Glu His Glu Glu Leu Tyr Ile Asn Leu Asp Gln Phe Leu 
            500                 505                 510         


Glu Asp Thr Ala Asp Ser Thr Pro Tyr Val Thr Asp Arg Arg Pro Ala 
        515                 520                 525             


Tyr Asn Ile His Ala Asn Arg Ile Gly Leu Tyr Trp Glu Asp Ser Gln 
    530                 535                 540                 


Asn Pro Lys Gln Tyr Lys Val Phe Asp Glu Asn Gly Met Tyr Ile Pro 
545                 550                 555                 560 


Glu Leu Val Val Thr Glu Asp Lys Lys Ala Pro Ile Lys Met Pro Ala 
                565                 570                 575     


Pro Arg Cys Ala Leu Ser Val Tyr Asp Leu Pro Ala Met Leu Phe Tyr 
            580                 585                 590         


Glu Tyr Leu Arg Glu Gln Gln Asp Asn Glu Phe Pro Ser Ala Glu Gln 
        595                 600                 605             


Val Ile Ile Glu Tyr Glu Asp Asp Tyr Arg Lys Phe Phe Lys Ala Val 
    610                 615                 620                 


Ala Glu Gly Lys Leu Lys Pro Phe Lys Arg Pro Lys Glu Phe Arg Asp 
625                 630                 635                 640 


Phe Leu Lys Lys Glu Tyr Pro Lys Leu Arg Met Ala Asp Ile Pro Lys 
                645                 650                 655     


Lys Leu Gln Leu Phe Leu Cys Ser His Gly Leu Cys Tyr Asn Asn Lys 
            660                 665                 670         


Pro Glu Thr Val Tyr Glu Arg Leu Asp Arg Leu Thr Leu Gln His Leu 
        675                 680                 685             


Glu Glu Arg Glu Leu His Ile Gln Asn Arg Leu Glu His Tyr Gln Lys 
    690                 695                 700                 


Asp Arg Asp Met Ile Gly Asn Lys Asp Asn Gln Tyr Gly Lys Lys Ser 
705                 710                 715                 720 


Phe Ser Asp Val Arg His Gly Ala Leu Ala Arg Tyr Leu Ala Gln Ser 
                725                 730                 735     


Met Met Glu Trp Gln Pro Thr Lys Leu Lys Asp Lys Glu Lys Gly His 
            740                 745                 750         


Asp Lys Leu Thr Gly Leu Asn Tyr Asn Val Leu Thr Ala Tyr Leu Ala 
        755                 760                 765             


Thr Tyr Gly His Pro Gln Val Pro Glu Glu Gly Phe Thr Pro Arg Thr 
    770                 775                 780                 


Leu Glu Gln Val Leu Ile Asn Ala His Leu Ile Gly Gly Ser Asn Pro 
785                 790                 795                 800 


His Pro Phe Ile Asn Lys Val Leu Ala Leu Gly Asn Arg Asn Ile Glu 
                805                 810                 815     


Glu Leu Tyr Leu His Tyr Leu Glu Glu Glu Leu Lys His Ile Arg Ser 
            820                 825                 830         


Arg Ile Gln Ser Leu Ser Ser Asn Pro Ser Asp Lys Ala Leu Ser Ala 
        835                 840                 845             


Leu Pro Phe Ile His His Asp Arg Met Arg Tyr His Glu Arg Thr Ser 
    850                 855                 860                 


Glu Glu Met Met Ala Leu Ala Ala Arg Tyr Thr Thr Ile Gln Leu Pro 
865                 870                 875                 880 


Asp Gly Leu Phe Thr Pro Tyr Ile Leu Glu Ile Leu Gln Lys His Tyr 
                885                 890                 895     


Thr Glu Asn Ser Asp Leu Gln Asn Ala Leu Ser Gln Asp Val Pro Val 
            900                 905                 910         


Lys Leu Asn Pro Thr Cys Asn Ala Ala Tyr Leu Ile Thr Leu Phe Tyr 
        915                 920                 925             


Gln Thr Val Leu Lys Asp Asn Ala Gln Pro Phe Tyr Leu Ser Asp Lys 
    930                 935                 940                 


Thr Tyr Thr Arg Asn Lys Asp Gly Glu Lys Ala Glu Ser Phe Ser Phe 
945                 950                 955                 960 


Lys Arg Ala Tyr Glu Leu Phe Ser Val Leu Asn Asn Asn Lys Lys Asp 
                965                 970                 975     


Thr Phe Pro Phe Glu Met Ile Pro Leu Phe Leu Thr Ser Asp Glu Ile 
            980                 985                 990         


Gln Glu Arg Leu Ser Ala Lys Leu  Leu Asp Gly Asp Gly  Asn Pro Val 
        995                 1000                 1005             


Pro Glu  Val Gly Glu Lys Gly  Lys Pro Ala Thr Asp  Ser Gln Gly 
    1010                 1015                 1020             


Asn Thr  Ile Trp Lys Arg Arg  Ile Tyr Ser Glu Val  Asp Asp Tyr 
    1025                 1030                 1035             


Ala Glu  Lys Leu Thr Asp Arg  Asp Met Lys Ile Ser  Phe Lys Gly 
    1040                 1045                 1050             


Glu Trp  Glu Lys Leu Pro Arg  Trp Lys Gln Asp Lys  Ile Ile Lys 
    1055                 1060                 1065             


Arg Arg  Asp Glu Thr Arg Arg  Gln Met Arg Asp Glu  Leu Leu Gln 
    1070                 1075                 1080             


Arg Met  Pro Arg Tyr Ile Arg  Asp Ile Lys Asp Asn  Glu Arg Thr 
    1085                 1090                 1095             


Leu Arg  Arg Tyr Lys Thr Gln  Asp Met Val Leu Phe  Leu Leu Ala 
    1100                 1105                 1110             


Glu Lys  Met Phe Thr Asn Ile  Ile Ser Glu Gln Ser  Ser Glu Phe 
    1115                 1120                 1125             


Asn Trp  Lys Gln Met Arg Leu  Ser Lys Val Cys Asn  Glu Ala Phe 
    1130                 1135                 1140             


Leu Arg  Gln Thr Leu Thr Phe  Arg Val Pro Val Thr  Val Gly Glu 
    1145                 1150                 1155             


Thr Thr  Ile Tyr Val Glu Gln  Glu Asn Met Ser Leu  Lys Asn Tyr 
    1160                 1165                 1170             


Gly Glu  Phe Tyr Arg Phe Leu  Thr Asp Asp Arg Leu  Met Ser Leu 
    1175                 1180                 1185             


Leu Asn  Asn Ile Val Glu Thr  Leu Lys Pro Asn Glu  Asn Gly Asp 
    1190                 1195                 1200             


Leu Val  Ile Arg His Thr Asp  Leu Met Ser Glu Leu  Ala Ala Tyr 
    1205                 1210                 1215             


Asp Gln  Tyr Arg Ser Thr Ile  Phe Met Leu Ile Gln  Ser Ile Glu 
    1220                 1225                 1230             


Asn Leu  Ile Ile Thr Asn Asn  Ala Val Leu Asp Asp  Pro Asp Ala 
    1235                 1240                 1245             


Asp Gly  Phe Trp Val Arg Glu  Asp Leu Pro Lys Arg  Asn Asn Phe 
    1250                 1255                 1260             


Ala Ser  Leu Leu Glu Leu Ile  Asn Gln Leu Asn Asn  Val Glu Leu 
    1265                 1270                 1275             


Thr Asp  Asp Glu Arg Lys Leu  Leu Val Ala Ile Arg  Asn Ala Phe 
    1280                 1285                 1290             


Ser His  Asn Ser Tyr Asn Ile  Asp Phe Ser Leu Ile  Lys Asp Val 
    1295                 1300                 1305             


Lys His  Leu Pro Glu Val Ala  Lys Gly Ile Leu Gln  His Leu Gln 
    1310                 1315                 1320             


Ser Met  Leu Gly Val Glu Ile  Thr Lys 
    1325                 1330         


<210>  1742
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1742

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1743
<211>  1262
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1743

Leu Gln Asn Ala Lys Tyr Ile Arg Asn Phe Ala Lys Arg Arg Pro Asn 
1               5                   10                  15      


Asn Tyr Tyr Ser Lys Gln Ser Val Lys Gln Lys Tyr Met Ile Ile Lys 
            20                  25                  30          


Glu Ser Lys Gln Arg Lys Asp Lys Val Arg Thr Gln Thr Glu Asp Ser 
        35                  40                  45              


Gln Leu Ser His Asn Arg Arg Ser Pro Lys Ala Gln Met Pro Tyr Thr 
    50                  55                  60                  


Glu Asn Asp Lys Leu Arg Ser Val Tyr Ala Ala Tyr Leu Asn Met Ala 
65                  70                  75                  80  


Arg Met Asn Leu Tyr Asn Thr Leu Arg Phe Ile Gly His Leu Tyr Gly 
                85                  90                  95      


Met Asp Asp Asn Ile Gln Glu Gly Glu Met Asp Lys Met Lys Val Ala 
            100                 105                 110         


Asn Phe Ala Asn His Pro His Leu Glu Lys Arg Leu Ser Val Arg Lys 
        115                 120                 125             


Ala Leu Leu Lys His Leu Pro Phe Leu His Cys Met Ala Gln Ala Tyr 
    130                 135                 140                 


Val Asn Thr Glu His Lys Tyr Thr Asp Asp Asn Asp Leu Gln Lys Val 
145                 150                 155                 160 


Leu Leu Asn Ile Ile Asn Val Val Ser Asn Gln Arg Asp His Leu Thr 
                165                 170                 175     


His Ala Asn Pro Tyr Asn Asn Asp Ala Asp Trp Ala Lys Gln Lys Glu 
            180                 185                 190         


Ile Glu Lys Gln Leu Leu Glu Pro Leu Glu Lys Ala Phe Met Phe Ser 
        195                 200                 205             


Lys His Lys Val Glu Thr Ile Phe Asp Tyr Ser Lys Ser Asp Met Ser 
    210                 215                 220                 


Phe Ile Asp Arg Leu Glu Arg Met Met Asp Thr Gly Asp Thr Ile Ile 
225                 230                 235                 240 


Val Lys Glu Asn Asn Lys Glu Arg Glu Leu Arg Asp Asn Gln Asp His 
                245                 250                 255     


Ser Asp Tyr Tyr Phe Arg Leu Arg Thr Pro Glu Gly Asp Ala Leu Ser 
            260                 265                 270         


Thr Val Gly Leu Thr Phe Leu Ile Cys Lys Leu Leu His Lys Lys His 
        275                 280                 285             


Ala Thr Ile Phe Ala Gln Arg Thr Gly Leu Phe Leu Glu Gln Ser His 
    290                 295                 300                 


Leu Asp Gly Tyr Ser Pro Phe Ser Lys Arg Glu Asn Glu Ile Met Phe 
305                 310                 315                 320 


Asn Ile Phe Cys His Glu Arg Ile Arg Leu Pro Lys Gly Arg Leu Glu 
                325                 330                 335     


Ser Thr Thr Asp Pro Met Ala Leu Gly Leu Asp Met Leu Ala Glu Leu 
            340                 345                 350         


Gln Lys Cys Pro Ala Glu Leu Phe Asn Thr Phe Gly Pro Ser Asp Arg 
        355                 360                 365             


Lys Leu Phe Glu Val Arg Asn Glu Asp Phe Ser Thr Asp Ser Ser Thr 
    370                 375                 380                 


Glu Asp Ile Ile Leu Met Arg Arg Tyr Gly Asp Arg Phe Ala Arg Leu 
385                 390                 395                 400 


Ala Met Gln Tyr Ile Asp Ser Phe Asn Ala Asp Pro Asn His Arg Asn 
                405                 410                 415     


Lys Arg Asp Ser Ala Pro Leu Pro Gly Met Ala Phe Gln Val Ser Val 
            420                 425                 430         


Gly Lys Phe Arg His Thr Phe Tyr Glu Arg Ala Pro Phe His Glu Gly 
        435                 440                 445             


Val Lys Asp Arg Val Arg Val Leu Gln Lys Glu Ile Asn Gly Phe Gly 
    450                 455                 460                 


Pro Leu Thr Lys Ile Glu Asp Leu Arg Gln Thr Asp Tyr Ala Leu Phe 
465                 470                 475                 480 


Ile Arg Gln Val Asn Asp Asp Ser Ser Asp Arg Leu Tyr Asp Pro Asp 
                485                 490                 495     


Thr Ala Gln Thr Arg Pro Tyr Ile Thr Asp His His Ala Ser Tyr Ala 
            500                 505                 510         


Ile Thr Gly Asp Arg Ile Gly Leu Met Trp Asn Asp Glu Asn Val Gln 
        515                 520                 525             


Val Leu Asn Asn Asp Thr Leu Cys Tyr Leu Pro Glu Leu Pro Ile Pro 
    530                 535                 540                 


Thr Ala Thr Asp Asp Ser Lys Lys Pro Trp Asn Val Asp Leu Thr Val 
545                 550                 555                 560 


Phe Asn Arg Ser Asn Gly Gly His Pro Lys Gly Asn Ile Ala Pro Arg 
                565                 570                 575     


Ala Trp Leu Ser Ile Tyr Asp Leu Pro Ala Leu Ile Phe Leu His Phe 
            580                 585                 590         


Leu Gly Gly Lys Pro Ala Ser Val Ile Lys Asp Thr Tyr Asn Ser Leu 
        595                 600                 605             


Met Lys Leu Phe Asp Asp Ile Ala Glu Gly Arg Arg Asp Pro Tyr Phe 
    610                 615                 620                 


Lys Gly Gln Ile Pro Gln Asp Pro Asn Ser Arg Lys Lys Val Ile Leu 
625                 630                 635                 640 


Ser Leu Arg Glu Gln Leu Thr Pro His Leu Met Thr Asp Tyr Gly Leu 
                645                 650                 655     


His Thr Arg Asp Ile Pro Asp Lys Ile Val Glu Tyr Leu Ile Gly Glu 
            660                 665                 670         


Gly Leu Ala Ala Asn Glu Gln Thr Ala Ile Leu His Ala Glu Glu Arg 
        675                 680                 685             


Phe Arg Lys Trp Cys Asp Ile Lys Val Lys Ala Met Lys Lys Asp Leu 
    690                 695                 700                 


Asp Leu Arg Ile Glu His Phe Asn Lys Asp Lys Glu Gln Ile Gly Asn 
705                 710                 715                 720 


Ser Ser Asn Arg Ile Gly Ser Lys Arg Tyr Val Asp Leu Arg Pro Gly 
                725                 730                 735     


Ser Leu Ala Arg Tyr Leu Ala Lys Asp Met Ile Ala Met Val Asp Pro 
            740                 745                 750         


Lys Asp Gly Ala Lys Pro Ser Gly Leu Asp Phe Thr Leu Leu Gln Ala 
        755                 760                 765             


Ala Ile Ala Thr Tyr Gln Gly Asn Gly Cys Pro Leu Glu Lys Thr Glu 
    770                 775                 780                 


Leu Gly Ala Thr Ile Lys Lys Ala Phe Ala Trp Gln Ala His Pro Phe 
785                 790                 795                 800 


Leu Pro Lys Ile Met Asn Leu Thr Val Ser Asp Thr Ile Asp Leu Tyr 
                805                 810                 815     


Ser Arg Tyr Gln Asn Glu Lys Thr Lys Tyr Leu Asp Arg Leu Leu Gln 
            820                 825                 830         


Ser His Lys Tyr Ser Asp Thr Tyr Phe Leu Arg Asn Ala His Arg Asn 
        835                 840                 845             


Met Met Ala Lys Thr Arg Ser Tyr Met Arg Asp Gln Lys Gly Gln Asp 
    850                 855                 860                 


Gly Thr Leu Ile Glu Gly Leu Ala His Arg Tyr Arg Lys Thr Leu Gln 
865                 870                 875                 880 


Leu Pro Asp Gly Leu Phe Thr Asn Ala Ile Arg Glu Gln Leu Ala Lys 
                885                 890                 895     


Ile Asn Asn Ser Asp Ile Gln Asp Ala Leu Asn Asn Pro Gln Phe Gly 
            900                 905                 910         


His Ser Ala Ala Tyr Leu Leu Asn Leu Trp Phe Thr Lys Ile Ile Gly 
        915                 920                 925             


Asp Gln Ser Gln Pro Phe Tyr Arg Ser Asp Thr His Gly His Tyr Lys 
    930                 935                 940                 


Arg His Tyr Lys Leu Leu Glu Thr Leu Tyr Pro Gln Lys Thr Pro Leu 
945                 950                 955                 960 


Asp Asp Ala Thr Leu Ser Ala Lys Leu Lys Gly Gly Lys Asn Ser Glu 
                965                 970                 975     


Ile Lys Gln Glu Ile Asp Lys Gln Ala Pro Val Ala Lys Lys Glu Ala 
            980                 985                 990         


Glu His Gln Lys Leu Met His Leu  Leu Arg Asp Leu Gln  Arg Asn Glu 
        995                 1000                 1005             


Arg Thr  Ile Arg Arg Tyr Arg  Asn Gln Asp Met Val  Leu Phe Leu 
    1010                 1015                 1020             


Met Ala  Lys Lys Leu Leu Leu  Ser Gly Gly Ala Pro  Phe Met Asn 
    1025                 1030                 1035             


Arg Ala  Glu Ser Asp Gly Ser  Arg Gln Phe Leu Leu  Gln Asn Ile 
    1040                 1045                 1050             


Val Pro  Ile Gly Val Asn His  Gly Glu Glu Asn Asn  Leu Leu Asn 
    1055                 1060                 1065             


Gln Lys  Val Ser Leu Ser Thr  Arg Ile Thr Leu Leu  Asp Asp Lys 
    1070                 1075                 1080             


Asn Lys  Pro Ile Lys Asp Ser  Glu Lys His Pro Met  Lys Arg Thr 
    1085                 1090                 1095             


Ile His  Gln Lys Glu Ile Lys  Met Lys Asn Tyr Gly  Asp Phe Phe 
    1100                 1105                 1110             


Arg Phe  Leu Tyr Asp Ser Arg  Ile Gly Ile Leu Leu  Ser Gln Leu 
    1115                 1120                 1125             


Pro Asp  Asp Glu Ala Gly Ile  Ala Arg Glu Lys Leu  Glu Lys Glu 
    1130                 1135                 1140             


Leu Asp  Thr Tyr Asp Asn Ser  Arg Thr Asp Ile Phe  Lys Val Ile 
    1145                 1150                 1155             


His Lys  Ile Glu Arg Gln Ile  Ile Glu Glu His Pro  Glu Leu Lys 
    1160                 1165                 1170             


Asn Pro  Asn Ser Gly His Phe  Thr Asn Asp Lys Gly  Thr Pro Tyr 
    1175                 1180                 1185             


Arg Asn  Asn Phe Thr Leu Leu  Leu Thr Leu Ser Ala  Leu Phe Ser 
    1190                 1195                 1200             


Glu Ala  Asp His Asn Leu Asn  Gln Lys Gly Lys Leu  Leu Lys Asp 
    1205                 1210                 1215             


Ile Arg  Asp Ala Phe Cys His  Asn Lys Tyr Ile Glu  Asn Ile Glu 
    1220                 1225                 1230             


Arg Ala  Ile Lys Glu Lys Glu  Glu Arg Glu Leu Pro  Lys Ile Ala 
    1235                 1240                 1245             


Glu Asn  Leu Thr Lys Trp Met  Lys Glu Phe Gly Glu  Gln Ser 
    1250                 1255                 1260         


<210>  1744
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1744

Met Asn Thr His Gln Glu Glu Leu Gln Ser Trp Ile Thr Arg Lys Arg 
1               5                   10                  15      


Leu Pro Asp Thr Glu Met Lys Lys Tyr Trp Ala Ala Tyr Met Asn Leu 
            20                  25                  30          


Ala Arg Leu Asn Phe Phe Lys Thr Leu Met Phe Ile Ser Asn Ser Ile 
        35                  40                  45              


Gly Asp Leu Lys Pro Ala Lys Asp Asn Asn Gly Lys Gly Asn Thr Glu 
    50                  55                  60                  


Val Asn Met His Asn Met Gly Ile Leu Thr Ala Leu Leu Gly Pro Glu 
65                  70                  75                  80  


Asp Glu Glu Lys Ala Arg Leu Leu Ile Phe Lys His Phe Pro Phe Leu 
                85                  90                  95      


Arg Thr Phe Cys Ile Glu Lys Glu Leu Ser Leu Ser Lys Gln Arg Thr 
            100                 105                 110         


Ile Leu Ile Asp Met Ala Cys Ile Ile Gly Arg Tyr Arg Asn Met Tyr 
        115                 120                 125             


Ser His Ser Ile Phe Ile Ser Asp Asp Asn Glu Lys Val Leu Glu Ser 
    130                 135                 140                 


Glu Lys Arg Cys Ser Glu Tyr Leu Gln Ser Ile Leu Thr Val Ser Thr 
145                 150                 155                 160 


Arg Ile Ile Lys Glu Arg Tyr Arg Ser Asn Lys Asn Asp Ala Gln Arg 
                165                 170                 175     


Gly Met Ile Asp Asp Lys Ser Leu Glu Phe Ile Ser Glu Asn Lys Val 
            180                 185                 190         


Lys Phe Val Tyr Asp Glu Asn Gly Lys Arg Ile Thr Ala Pro Asn Lys 
        195                 200                 205             


Lys Tyr Tyr Leu Ser Thr Ile Asp Lys Asp Asn Thr His Leu Ser Tyr 
    210                 215                 220                 


Phe Gly Lys Leu Met Leu Thr Cys Ile Leu Leu Glu Lys Lys Tyr Ala 
225                 230                 235                 240 


Thr Ala Phe Leu Thr Gln Cys His Phe Leu Asp Ala Phe Asn Asp Ser 
                245                 250                 255     


Glu Val Ala Pro Lys Leu Ser Glu Arg Arg Leu Met Leu Glu Val Met 
            260                 265                 270         


Thr Ala Leu Arg Ile Arg Leu Ala Glu Lys Lys Leu Ser Asn Glu Lys 
        275                 280                 285             


Ser Glu Val Gln Ile Ser Leu Asp Ile Leu Asn Glu Leu Lys Lys Cys 
    290                 295                 300                 


Pro Phe Glu Leu Tyr Glu Leu Leu Gly Ser Glu Asp Lys Arg Leu Phe 
305                 310                 315                 320 


Thr Ile Val Ala Asp Thr Gly Glu Thr Ile Leu Leu Arg Arg His Glu 
                325                 330                 335     


Asp Arg Phe Pro Gln Leu Ala Leu Ser Trp Ile Asp Ser Ser Lys Ala 
            340                 345                 350         


Phe Asp His Leu Arg Phe Gln Val Asn Ala Gly Lys Leu Arg Tyr Leu 
        355                 360                 365             


Phe Arg Asp Asn Lys His Cys Ile Asp Gly Gln Thr Arg Met Arg Val 
    370                 375                 380                 


Leu Glu Glu Pro Leu Asn Gly Tyr Arg Arg Leu Met Glu Phe Glu Glu 
385                 390                 395                 400 


Glu Arg Ile Gln Lys Gln Ser Gly Glu Ile Arg Ser Leu Trp Pro Gly 
                405                 410                 415     


Leu Asp Ile Leu Asn Lys Asp Glu Thr Pro Arg Asn Asp Ala Ser Val 
            420                 425                 430         


Leu Pro Tyr Ile Ser Asp Tyr Arg Val Arg Tyr Leu Phe Asp Gly Asp 
        435                 440                 445             


Asn Ile Gly Ile Ser Ile Gly Asp Phe Thr Pro Ser Ile Thr Lys Thr 
    450                 455                 460                 


Asp Glu Thr Lys Tyr Arg Val Thr Gly Lys Thr Ala Asp Cys Cys Leu 
465                 470                 475                 480 


Ser Lys Tyr Glu Leu Pro Gly Leu Leu Phe Tyr His Leu Leu Thr Leu 
                485                 490                 495     


Arg His Gly Asp Asn Lys Arg Ser Thr Lys Asn Ala Glu Asp Ile Ile 
            500                 505                 510         


Ile Asp Ala Ile Lys Arg Tyr Lys Arg Leu Phe Ser Asp Val Lys Glu 
        515                 520                 525             


Gly Ile Leu Lys Pro Ile Lys Glu Glu Asn Ala Asn Gln Leu Gly Asn 
    530                 535                 540                 


Arg Ile Trp Asn Ser Tyr Gly Ile Asp Ile Lys Asp Ile Pro Asp Lys 
545                 550                 555                 560 


Ile Ile Asp Tyr Leu Leu Val Arg Glu Cys Asn Glu Asp Glu Lys Phe 
                565                 570                 575     


Thr Ala Trp Lys Asn Gly Leu Ile Ser Glu Met Leu Gln Ser Thr Lys 
            580                 585                 590         


Asn Arg Ile Lys Arg Phe Glu Lys Asp Ser Glu Ala Val Ile Ser Ser 
        595                 600                 605             


Asp Asn Lys Pro Gly Lys Lys Asn His Val Ser Leu Lys Pro Gly Ala 
    610                 615                 620                 


Tyr Ala Ser Phe Ile Ala Asn Asp Ile Val Phe Phe Gln Glu Cys Gly 
625                 630                 635                 640 


Ala Thr Glu Lys Met Thr Gly Leu Asn Phe Lys Val Met Gln Ser Arg 
                645                 650                 655     


Leu Ala Thr Phe Thr Lys Asp Gly Ser Thr Ser Phe Asn Ile Leu Leu 
            660                 665                 670         


Gln Thr Leu Lys Asn Ala His Leu Val Ser Asn Thr Tyr Gly Lys Gly 
        675                 680                 685             


Asp His Pro Phe Leu Tyr Arg Val Ile Lys Gln Gln Pro Ser Asp Ile 
    690                 695                 700                 


Val Gln Phe Tyr Lys Ile Tyr Leu Asn Glu Lys Val Leu Tyr Leu Gln 
705                 710                 715                 720 


Ser Asp Ile Pro Asp Asn Ala Ile Phe Leu His Gly Glu Arg Lys Arg 
                725                 730                 735     


Trp Glu Asn Arg Asn Glu Gln Tyr Tyr Arg Asp Leu Ala Glu Arg Tyr 
            740                 745                 750         


Leu Gln Arg Pro Ile Gln Leu Pro Arg Gln Leu Phe Glu Ser His Ile 
        755                 760                 765             


Arg Gln Leu Leu Leu Ser Asp Cys Ile Lys Gly Glu Arg Gly Asn Asp 
    770                 775                 780                 


Leu Lys Glu Ala Ile Asn Ser Ala Ala Ser Gln Gly Arg Cys Asn Thr 
785                 790                 795                 800 


Thr Tyr Met Ile Met Glu Tyr Phe Ala Asp Tyr Leu Cys Asp Gly Thr 
                805                 810                 815     


Gln Phe Phe Tyr Gly Leu Phe Asp Gly Asp Leu Ser His Glu Tyr Asn 
            820                 825                 830         


Tyr Arg Phe Tyr Ser Leu Ile Ser Asn Asn Ile Glu Asn Ser Lys Lys 
        835                 840                 845             


Leu Val Leu Thr Leu Lys Lys Gly Asn Asn Ser Lys Glu Ser Pro Phe 
    850                 855                 860                 


Ile Ser Ala Leu Glu Arg Gly Ile His Trp Ser Lys Met Asn Pro Leu 
865                 870                 875                 880 


Met Lys Lys Gly Leu Lys Asn Asp Ser Ser Glu Gly Asp Phe Val His 
                885                 890                 895     


Ala Ala Lys Arg Ala Tyr Lys Glu Met Thr Glu Thr Glu Arg Met Phe 
            900                 905                 910         


Arg Arg Tyr Ala Val Gln Asp Glu Val Leu Phe Leu Ala Ala Lys Ile 
        915                 920                 925             


Thr Ile Arg Arg Ala Leu Gly Leu Ser Glu Gln Tyr Asn Cys Leu Leu 
    930                 935                 940                 


Gly Asp Ile Lys Pro Gln Gly Gly Ser Leu Leu Glu Gln Thr Ile Pro 
945                 950                 955                 960 


Ser Ile Thr Thr Lys His Thr Ile Asn Thr Gly Asn Lys Lys Gln Lys 
                965                 970                 975     


Pro Lys Gln Val Gln Ile Leu Gln Lys Asn Val Lys Leu Lys Asp Phe 
            980                 985                 990         


Gly Lys Val Phe Lys Leu Leu Asn  Asp Arg Arg Ile Phe  Asp Leu Leu 
        995                 1000                 1005             


Phe Asn  Lys Gly Asn Glu Ala  Val Ser Met Thr Asp  Leu Cys Glu 
    1010                 1015                 1020             


Glu Leu  Glu Arg Tyr Asp Arg  His Arg Val Asp Val  Phe Asp Ser 
    1025                 1030                 1035             


Val Leu  Lys Tyr Glu Ser Lys  Ile Thr Lys Gly Tyr  Thr Asn Lys 
    1040                 1045                 1050             


Glu Leu  Met Asn Glu Ser Gly  Gln Ile Asp Phe Lys  Ala Ile Gln 
    1055                 1060                 1065             


Ala Phe  Asp Lys Gln Asn Thr  Thr Ser Asp Lys Glu  Asp Leu Arg 
    1070                 1075                 1080             


Leu Ile  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Gln Tyr Asn 
    1085                 1090                 1095             


Asn Glu  Pro Ile Leu Phe Asp  Lys Asp Ile Pro Glu  Ile Ala Asp 
    1100                 1105                 1110             


Glu Ile  Ser Ile Ile Ala Lys  Asp Ile Glu Glu Asn  Thr Lys 
    1115                 1120                 1125         


<210>  1745
<211>  1403
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1745

Met Gly Lys Asn Lys Gln Lys Lys Lys Ile Gln Ser Gln Asp Ser Ser 
1               5                   10                  15      


Lys Ala Asn Asn Pro Tyr Pro Ser Val Thr Lys Pro Gln Arg Pro Asp 
            20                  25                  30          


Phe Cys Leu Glu Gly Phe Tyr Thr Gln Gln Ala Phe Val Asp Val Arg 
        35                  40                  45              


His Val Ala Ala Asn Tyr Phe Asn Leu Ala His Asn Asn Phe Tyr Lys 
    50                  55                  60                  


Thr Leu Ile Tyr Val Leu Thr Arg Ser Gly Ile Asp Leu Lys Thr Leu 
65                  70                  75                  80  


Asn Phe Trp Asn Phe Lys Asp Asp Ser Ile Gly Thr Val Leu Gln Thr 
                85                  90                  95      


Val Cys Asp Ala Thr Phe Gly Ser Gly Glu Gln Lys Gln Ala Ile Lys 
            100                 105                 110         


Asp Tyr Tyr Phe Ser Ile Glu Glu Lys Lys Leu Ile Val Glu Asn Asn 
        115                 120                 125             


Lys Glu Asn Asp Ser Asn Lys Lys Lys Ser Asp Ala Glu Ile Arg Glu 
    130                 135                 140                 


Leu Ser Leu Gln Arg Ala Glu Lys Asp Phe Gly Ser Phe Val Leu Phe 
145                 150                 155                 160 


Glu Asp Met Gln Gly Arg Ile Gln Lys Lys Leu Phe His His Ile Pro 
                165                 170                 175     


Ala Phe Gly Pro Ile Met Ala Asp Val Ala Ser Tyr Glu Ala Tyr Lys 
            180                 185                 190         


Asn Arg Gln Lys Ser Asp Glu Leu Lys Asp Lys Asn Lys Glu Lys Ile 
        195                 200                 205             


Leu Arg Gly Ile Thr Phe Gln Gln Cys Leu Glu Thr Leu Ile Ile Ile 
    210                 215                 220                 


Ala Asn Ala Leu Asn Tyr Tyr Arg Asn Phe Tyr Thr His Glu Ile Pro 
225                 230                 235                 240 


Tyr Asn Glu Leu Glu Glu Glu Trp Ser Gln Thr Leu Arg Glu Ala Lys 
                245                 250                 255     


Leu Val Lys Tyr Met Asn Asn Val Phe Lys Ala Ser Gln Arg Leu Asp 
            260                 265                 270         


Lys Lys Arg Glu Leu Val Thr Thr Glu Ala Met Thr Phe Leu Thr Gly 
        275                 280                 285             


His Gly Ser Gly Asp Pro Cys Asp Arg Met Lys Glu Ile Pro Asn Gly 
    290                 295                 300                 


Glu Lys Thr Tyr Phe Asp Glu Lys Lys His Arg Asn Val Thr Ile Lys 
305                 310                 315                 320 


Val Tyr Arg Tyr Glu Glu Asn Glu Asn Phe Phe Phe Lys Ile Ala Gly 
                325                 330                 335     


Arg Glu Phe Thr Thr Glu Asp Gly Gly Lys Ala Asn Tyr Leu Ser Asp 
            340                 345                 350         


Phe Gly Lys Leu Leu Phe Cys Cys Leu Phe Leu Lys Arg Gln Gln Thr 
        355                 360                 365             


Gln Asn Phe Ala Ile Glu Ser Arg Leu Leu Glu Phe Ser Pro Tyr Leu 
    370                 375                 380                 


Leu Lys Pro His Glu Leu Gln Lys Lys Gln Ala Glu Glu Asn Lys Arg 
385                 390                 395                 400 


Val Asp Lys Glu Asn Lys Leu Arg Gln Ala Gln Gly Lys Lys Arg Met 
                405                 410                 415     


Leu Thr Pro Lys Gln Phe Thr Lys His Asp Ser Leu Gln Asn Glu Ile 
            420                 425                 430         


Ile Leu Asp Met Leu Gly Ile Tyr His Ile Arg Arg Pro Leu Glu Lys 
        435                 440                 445             


Arg Ile Asp Ala Lys Ala Thr Pro Gly Thr Leu Ala Met Asp Met Leu 
    450                 455                 460                 


Asn Glu Leu Arg Arg Cys Pro Ser Glu Leu Tyr Gln Thr Phe Ser Ala 
465                 470                 475                 480 


Asp Asp Lys Asp Ile Phe Glu Arg Glu Val Ser Asp Pro Lys Asp Gly 
                485                 490                 495     


Ser Pro Arg Ser Ala Lys Ala Glu Glu Lys Val Lys Leu Ile Arg Tyr 
            500                 505                 510         


Thr Asp Arg Phe Pro Tyr Leu Ala Leu Arg Tyr Ile Asp Glu Thr Asn 
        515                 520                 525             


Leu Ile Gly Asp Ile Arg Phe His Ile Arg Leu Gly Asn Tyr Arg Phe 
    530                 535                 540                 


His Phe Tyr Asp Lys Thr Cys Val Asp Gly Asn Pro Lys Ile Arg Ser 
545                 550                 555                 560 


Trp Gln Lys Glu Ile Asn Gly Phe Gly Lys Trp Gln Glu Ile Glu Glu 
                565                 570                 575     


Lys Arg Lys Ser Lys Trp Ala Asn Gln Phe Gln Lys Arg Glu Tyr Val 
            580                 585                 590         


Asn Thr Arg Gln Glu Tyr Gly Glu Met Glu Leu Glu Gln Pro Val Lys 
        595                 600                 605             


Asp His Ala Asp Thr Lys Pro Tyr Ile Thr Asp Trp Thr Ala Ala Tyr 
    610                 615                 620                 


Asn Ile His Ala Asn Arg Ile Gly Leu Tyr Trp Gly Leu Glu Asp Gly 
625                 630                 635                 640 


Met Phe Leu Pro Asp Leu Asn Thr Ile Val Asp Pro Thr Asp Ala Asn 
                645                 650                 655     


Ala Ser Gln Glu Glu Leu Arg Lys Ser Glu Met Lys Pro Arg His Arg 
            660                 665                 670         


Ala Pro Val Ile Met Lys Glu Pro Leu Cys Thr Leu Ser Thr Tyr Asp 
        675                 680                 685             


Leu Pro Ala Leu Leu Phe Tyr Asn Tyr Leu Phe Lys His Tyr Asn Ala 
    690                 695                 700                 


Ala Lys Tyr Lys Met Pro Met Pro Asn Lys Ile Ile Lys Asp Ala Tyr 
705                 710                 715                 720 


Asp Gly Leu Lys Ala Phe Ile Asp Ala Ile Ala Ala Arg Lys Lys Gly 
                725                 730                 735     


Lys Asp Leu Glu Glu Val Leu Gln Gln Lys Gly Val Arg Glu Phe Asp 
            740                 745                 750         


Ile Pro Lys Ala Leu Arg Lys Arg Leu Glu Ser Gln Gly Lys Pro Glu 
        755                 760                 765             


Gln Phe Asn Asn Lys Ile Tyr Met Arg Leu Val Glu Arg Val Tyr Gly 
    770                 775                 780                 


Arg Tyr Asp Ile Glu Arg Glu Met Tyr Val Pro Gly Lys Leu Ser Glu 
785                 790                 795                 800 


Lys Leu Glu Glu Ile Glu Tyr Arg Ile Lys Ala Phe Lys Asp Lys Lys 
                805                 810                 815     


Ala Lys Ile Asp Ser Gly Asp Asn Lys Tyr Ala Lys Lys Gly Tyr Ala 
            820                 825                 830         


Asp Ile Arg His Gly Val Leu Ala Arg Tyr Leu Ala Lys Ser Phe Met 
        835                 840                 845             


Gln Trp Gln Pro Thr Lys Asp Lys Gly His Asp Lys Ile Thr Gly Leu 
    850                 855                 860                 


Asn Tyr Ser Val Met Thr Ala Phe Leu Ser Thr Tyr Gly Ile Asn Ser 
865                 870                 875                 880 


Asp Ile Val Gln Leu Arg Thr Leu Leu Glu Lys Ala Lys Leu Ile Gly 
                885                 890                 895     


Ser Ala Asn Pro His Pro Phe Leu Pro Glu Val Leu Ala Glu Ser Pro 
            900                 905                 910         


Gln Asn Ile Glu Asp Leu Tyr Phe Ile Tyr Leu Lys Gln Glu Gln Lys 
        915                 920                 925             


Phe Ala Glu Gly Leu Asn Ser His His Gly Lys Leu Lys Ala Phe Lys 
    930                 935                 940                 


Gly Asn Leu Gln Asp Lys Ile Lys Tyr Ile Asn Glu Asn Lys Ser Ser 
945                 950                 955                 960 


Ile Asp Gln Ile Leu Ala Gln Ile Pro Phe Val His Ala Asp Arg Glu 
                965                 970                 975     


Lys Trp Arg Arg Thr Asp Ser Val Asp Lys Tyr Tyr Thr Asp Tyr Ala 
            980                 985                 990         


Gly Arg Tyr His Thr Ile Met Leu  Pro Asp Ser Leu Phe  Thr Pro Tyr 
        995                 1000                 1005             


Ile Ile  Arg Leu Met Lys Ser  Cys Leu Pro Asn Asp  Lys Thr Leu 
    1010                 1015                 1020             


Met Ser  Arg Ile Lys Ala Cys  Glu Ser Asp Ser Arg  Gln Thr Leu 
    1025                 1030                 1035             


Gly Ala  Ala Trp Leu Ile Glu  Tyr Tyr Phe Glu His  His Met Lys 
    1040                 1045                 1050             


Asp Lys  His Gln Gln Phe Tyr  Asn Ala Asn Ile Phe  Arg Arg Ala 
    1055                 1060                 1065             


Tyr Lys  Pro Phe Thr Thr Met  Asn Asn Asp Phe Val  Lys Asn Gln 
    1070                 1075                 1080             


Asn Gly  Gly Asn Thr Asn Glu  Pro Leu Pro Tyr Tyr  Asn Ser Lys 
    1085                 1090                 1095             


Lys Glu  Ile Glu Glu Lys Leu  Ser Tyr Thr Glu Glu  Asp Ile Arg 
    1100                 1105                 1110             


Asn Phe  Val Tyr Asn Val Trp  Arg Gly Lys Thr Lys  Arg Glu Glu 
    1115                 1120                 1125             


Ile Glu  Ile Leu Lys Asn Gln  Ile Lys Asp Val Lys  Asp Thr Glu 
    1130                 1135                 1140             


Lys Val  Ile Arg Arg Tyr Arg  Thr Gln Asp Val Thr  Leu Phe Leu 
    1145                 1150                 1155             


Ala Ala  Lys Asp Leu Leu Thr  Thr Gln Leu Ser Lys  Asp Asp Asn 
    1160                 1165                 1170             


Met Ala  Asp Ala Thr Lys Gln  Ala Met Lys Asn Leu  Lys Glu Lys 
    1175                 1180                 1185             


Ala Glu  Cys Leu Lys Leu Lys  Asp Phe Asp Tyr Asp  Glu Gly Phe 
    1190                 1195                 1200             


Ser Phe  Leu Ser Asp Gly Asp  Asn Pro Glu Ser Gly  Ile Val Tyr 
    1205                 1210                 1215             


Thr Tyr  Glu Tyr Lys Thr Lys  Thr Gly Arg Thr Val  Lys Ile Thr 
    1220                 1225                 1230             


Gln Lys  Gly Val Ser Leu Lys  Asn Tyr Gly Asn Ile  Tyr Arg Ile 
    1235                 1240                 1245             


Leu Gly  Asp Asp Arg Phe Lys  Ser Leu Met Glu Gly  Ile Ala Asn 
    1250                 1255                 1260             


Ile Ala  Thr Thr Asp Ser Ile  Glu Val Thr Phe Asn  Asp Leu Thr 
    1265                 1270                 1275             


Thr Glu  Phe Ala Asn Tyr Asp  Glu Arg Arg Ser Ala  Met Phe Lys 
    1280                 1285                 1290             


Met Val  His Glu Leu Glu Gly  Lys Ala Phe Ile Arg  Asn Glu Lys 
    1295                 1300                 1305             


Glu Leu  Gln Asp Pro Asn Asn  Pro Val Phe His Ile  Lys Asn Asp 
    1310                 1315                 1320             


Leu Ala  Lys Asp Pro Arg Arg  Asn Asn Phe Ser Ser  Leu Leu Glu 
    1325                 1330                 1335             


Leu Leu  Gln Glu Tyr Ser Asp  Lys Asp Gln Lys Val  Met Val Ala 
    1340                 1345                 1350             


Ile Arg  Asn Ala Ile Gly His  Asp Tyr Tyr Met Asp  Ile Thr Leu 
    1355                 1360                 1365             


Leu Asp  Arg Thr Asn Ser Lys  Ala Lys Arg Val Pro  Asn Ile Ser 
    1370                 1375                 1380             


Leu Leu  Met Glu His Thr Leu  Asn Lys Lys Lys Asp  Asn Pro Ser 
    1385                 1390                 1395             


Gln Asp  Lys Lys Lys 
    1400             


<210>  1746
<211>  1119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1746

Met Thr Glu Gln Asn Glu Arg Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Ala His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Cys Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Gly Thr Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Thr Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Gly Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Leu Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Glu Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Gly Glu Ile Asp Thr Leu Asp 
    530                 535                 540                 


Arg Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Arg Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Gly Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Tyr Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Leu Ala Lys Leu Lys Lys Glu Ile Leu Glu Ala 
        835                 840                 845             


Lys Glu His Pro Tyr Leu Asp Phe Lys Ser Trp Gln Lys Phe Glu Arg 
    850                 855                 860                 


Glu Leu Arg Leu Val Lys Asn Gln Asp Ile Ile Thr Trp Met Met Cys 
865                 870                 875                 880 


Arg Asp Leu Met Glu Glu Asn Lys Val Glu Gly Leu Asp Thr Gly Thr 
                885                 890                 895     


Leu Tyr Leu Lys Asp Ile Arg Thr Asp Val Tyr Glu Gln Gly Ser Leu 
            900                 905                 910         


Asn Val Leu Asn Arg Val Lys Pro Met Arg Leu Pro Val Val Val Tyr 
        915                 920                 925             


Arg Ala Asp Ser Arg Gly His Val His Lys Glu Gln Ala Pro Leu Ala 
    930                 935                 940                 


Thr Val Tyr Ile Glu Glu Arg Asp Thr Lys Leu Leu Lys Gln Gly Asn 
945                 950                 955                 960 


Phe Lys Ser Phe Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe 
                965                 970                 975     


Val Asp Thr Gly Gly Leu Ala Met Glu Gln Tyr Pro Ile Ser Lys Leu 
            980                 985                 990         


Arg Val Glu Tyr Glu Leu Ala Lys  Tyr Gln Thr Ala Arg  Val Cys Ala 
        995                 1000                 1005             


Phe Glu  Gln Thr Leu Glu Leu  Glu Glu Ser Leu Leu  Thr Arg Tyr 
    1010                 1015                 1020             


Pro His  Leu Pro Asp Glu Ser  Phe Arg Glu Met Leu  Glu Ser Trp 
    1025                 1030                 1035             


Ser Asp  Pro Leu Leu Asp Lys  Trp Pro Asp Leu His  Gly Asn Val 
    1040                 1045                 1050             


Arg Leu  Leu Ile Ala Val Arg  Asn Ala Phe Ser His  Asn Gln Tyr 
    1055                 1060                 1065             


Pro Met  Tyr Asp Glu Thr Ile  Phe Ser Ser Ile Arg  Lys Tyr Asp 
    1070                 1075                 1080             


Pro Ser  Ser Pro Asp Ala Ile  Glu Glu Arg Met Gly  Leu Asn Ile 
    1085                 1090                 1095             


Ala His  Arg Leu Ser Glu Glu  Met Lys Gln Ala Lys  Glu Met Val 
    1100                 1105                 1110             


Glu Arg  Ile Ile Gln Ala 
    1115                 


<210>  1747
<211>  1000
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1747

Met Glu Glu Ala Asn Arg Tyr Ile Tyr Gly Ala Tyr Phe Asn Met Ala 
1               5                   10                  15      


Arg Asp Asn Phe Leu Asn Thr Ile Lys Leu Leu Ala Asp Lys Met Lys 
            20                  25                  30          


Leu Gly Ala Thr Ser Gly Phe Gly Lys Asp Gly Asn Glu Val Asn Asp 
        35                  40                  45              


Ile Asn Glu Leu Phe Gly Asp Lys Asn Thr Tyr Ala Asn Ile Glu Asn 
    50                  55                  60                  


Val Val Glu Phe Tyr Phe Pro Trp Ile Lys Ala Leu Glu Gly Arg Phe 
65                  70                  75                  80  


Ser Leu Asp Lys Gly Asp Arg Asn Leu Asn Asp Met Lys Met Phe Tyr 
                85                  90                  95      


Lys Ser Val Leu Thr Ala Phe Phe Thr Ala Val Asp Ser Leu Arg Asn 
            100                 105                 110         


Lys Tyr Thr His Tyr Ser His Lys Asp Leu Asn Ile Arg Glu Ile Lys 
        115                 120                 125             


Ile Glu Cys Thr Leu Gly Gly Lys Asp Tyr Cys Ile Gly Leu Leu Asn 
    130                 135                 140                 


Ala Leu Asp Cys Ile Tyr Asp Ser Ala Val Asn Leu Leu Lys Leu Arg 
145                 150                 155                 160 


Phe Met Ala Asp Glu Asp Glu Val Ala His Leu Arg Arg Cys Lys Ala 
                165                 170                 175     


Val Asn Lys Lys Val Val Val Arg Thr Glu Lys Asp Gly Phe Tyr Tyr 
            180                 185                 190         


Arg Leu Ser Asp Asn Gly Glu Val Thr Glu Lys Gly Val Ile Phe Ile 
        195                 200                 205             


Ala Ser Met Phe Leu Asn Arg Lys Tyr Gly Phe Leu Phe Leu Lys Gln 
    210                 215                 220                 


Leu Glu Gly Phe Lys Arg Ser Asp Glu Lys Arg Tyr Arg Leu Thr Leu 
225                 230                 235                 240 


Glu Ala Phe Leu Ala Phe Ser Asn Ile Lys Pro Val Asp Arg Leu Lys 
                245                 250                 255     


Ser Asp Lys Leu Asp Arg Ala Ser Leu Gly Leu Asp Met Leu Asn Glu 
            260                 265                 270         


Leu Thr Lys Ile Pro Lys Glu Leu Ser Glu Thr Leu Ser Val Asp Cys 
        275                 280                 285             


Leu Tyr Lys Tyr Leu Ala Ser Asp Gly Glu Asp Asp Leu Arg Ser Arg 
    290                 295                 300                 


Ile Arg Tyr Gln Asp Arg Phe Val Pro Leu Ala Leu Glu Phe Ile Ser 
305                 310                 315                 320 


Gln Ser Asp Glu Phe Lys Asp Phe Arg Phe Tyr Thr Tyr Val Gly Asn 
                325                 330                 335     


Tyr Val Tyr Lys Gly Tyr Ile Lys Arg Leu Ile Asp Gly Thr Asp Lys 
            340                 345                 350         


Glu Arg Tyr Leu Ser Asp Arg Leu Cys Gly Phe Tyr Lys Ser Val Asn 
        355                 360                 365             


Asp Ala Ser Ser Asp Ala Ile Ala Gln Lys Tyr Gly Val Glu Ile Lys 
    370                 375                 380                 


Asp Ser Asn Glu Pro Asp Tyr Met Leu Pro Asp Ser Phe Arg Pro His 
385                 390                 395                 400 


Val Leu Arg Ala Thr Pro His Phe Val Ile Asn Asn Asn Asn Ile Gly 
                405                 410                 415     


Ile Lys Ile Cys Gly Asn Asp Cys Leu Pro Val Val Asn Gly Lys Gly 
            420                 425                 430         


Val Glu Ser Pro Glu Pro Asp Tyr Trp Leu Ser Ile Tyr Glu Leu Pro 
        435                 440                 445             


Ala Met Leu Phe Tyr Ala Tyr Leu Arg Glu Lys Asn Gly Lys Leu Leu 
    450                 455                 460                 


Lys Asp Tyr Lys Ser Ile Arg Glu Leu Ile Glu Asp Val Glu Lys Lys 
465                 470                 475                 480 


Ala Asp Glu Lys Asn Asp Arg Asp Lys Gly Ala Leu Met Ala Arg His 
                485                 490                 495     


Ile Asp Lys Glu Ile Ile Trp Thr Gln Thr Lys Leu Asp Glu Val Lys 
            500                 505                 510         


Arg Leu Glu Glu Lys Lys Val Ala Ala Tyr Gly Lys Lys Gly Arg Val 
        515                 520                 525             


Val Leu Lys Ser Gly Arg Met Ala Asp Leu Leu Ala His Asp Met Val 
    530                 535                 540                 


Arg Leu Gln Pro Ala Thr Lys Gly Ser Asp Lys Ile Thr Gly Ala Asn 
545                 550                 555                 560 


Phe Gln Ala Leu Gln Val Ser Leu Ala Tyr Phe Lys Arg Asp Ile Leu 
                565                 570                 575     


Ala Asp Val Phe Ser Arg Ala Met Leu Thr Thr Gly Asn His Arg His 
            580                 585                 590         


Pro Phe Leu Tyr Arg Ile Asp Val Ser His Cys Ser Ser Leu Arg Asp 
        595                 600                 605             


Phe Tyr Val Ala Tyr Leu Gly Glu Arg Arg Lys Tyr Phe Glu Asp Val 
    610                 615                 620                 


Ala Lys Lys Ile Thr Lys Asn Lys Leu Asn Thr Pro Cys His Ile Leu 
625                 630                 635                 640 


Arg Arg Leu Gln Arg Glu Gly Ser Gly Glu Glu Ala Gly Lys Asp Val 
                645                 650                 655     


Lys Pro Lys Phe Leu Pro Arg Gly Ile Phe Thr Gly Ser Ile Lys Ser 
            660                 665                 670         


Cys Leu Glu Lys Ser Ala Leu Asn Ile Asn Ile Arg Asn Ala Arg Asn 
        675                 680                 685             


Asp Val Lys Pro Ala Ile Asn Ala Ala Tyr Leu Ile Phe Met Tyr Tyr 
    690                 695                 700                 


Lys Glu Ile Glu Lys Gly Glu Phe Gln Gly Phe Tyr Gly Glu Lys Arg 
705                 710                 715                 720 


Arg Tyr Asp Ile Leu Glu Glu Gly Lys Pro Leu Asp Leu Asp Glu Arg 
                725                 730                 735     


Lys Lys Ala Leu Ala Ser Ile Lys Pro Ala Lys Ile Asp Val Ser Glu 
            740                 745                 750         


Ala Asn Met Pro Met Ser Lys Glu Glu His Leu Met Arg Lys Arg Tyr 
        755                 760                 765             


His Ala Val Cys Asn Asn Glu Ser Ala Ile Arg Met Tyr Gln Val Gln 
    770                 775                 780                 


Asp Ile Leu Leu Leu Leu Met Ala Lys Asp Ile Phe Lys Lys Ala Leu 
785                 790                 795                 800 


Ser Glu Val Val Met Ser Lys Lys Ile Gly Leu Glu Asn Leu Asn Gly 
                805                 810                 815     


Ile Phe Asp Ala Pro Val Asn Phe Val Lys Asn Phe Asp Asn Ile Lys 
            820                 825                 830         


Leu Thr Ala Thr Gly Ile Lys Ile Lys Asp Tyr Gly Lys Val Cys Arg 
        835                 840                 845             


Leu Gly Thr Asp Phe Lys Phe Asn Ser Leu Ile Lys Ala Phe His Lys 
    850                 855                 860                 


Val Tyr Ser Lys Ser Val Glu Met Asp Tyr Ser Asp Tyr Leu Lys Glu 
865                 870                 875                 880 


Glu Glu Glu Phe Glu Lys Tyr Arg Leu Asn Met Val Lys Leu Cys Arg 
                885                 890                 895     


Glu Val Glu Arg Gly Ile Thr Glu Asp Leu His Leu Ser Leu Asp Gly 
            900                 905                 910         


Lys Ser His Leu Ser Phe Asn Asp Asp Val Ile Lys Ser Tyr Asn Asp 
        915                 920                 925             


Lys Tyr Asn Val Phe Asn Gly Asp Asp Leu Thr Phe Phe Ile Asn Ala 
    930                 935                 940                 


Arg Asn Met Phe Met His Gly Asp Tyr Lys Tyr Glu Cys Val Lys Tyr 
945                 950                 955                 960 


Val Val Ser Glu His Phe Lys Gly Ser Leu Asn Asp Val Ser Phe Ala 
                965                 970                 975     


Lys Glu Thr Tyr Gly His Phe Cys Asn Leu Leu Glu Ser Met Arg Lys 
            980                 985                 990         


Lys Thr Gly Leu Arg Ile Asp Ile  
        995                 1000 


<210>  1748
<211>  1000
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1748

Met Glu Glu Ala Asn Arg Tyr Ile Tyr Gly Ala Tyr Phe Asn Met Ala 
1               5                   10                  15      


Arg Asp Asn Phe Leu Asn Thr Ile Lys Leu Leu Ala Asp Lys Met Lys 
            20                  25                  30          


Leu Gly Ala Thr Ser Gly Phe Gly Lys Asp Gly Asn Glu Val Asn Asp 
        35                  40                  45              


Ile Asn Glu Leu Phe Gly Asp Lys Asn Thr Tyr Ala Asn Ile Glu Asn 
    50                  55                  60                  


Val Val Glu Phe Tyr Phe Pro Trp Ile Lys Ala Leu Glu Gly Arg Phe 
65                  70                  75                  80  


Ser Leu Asp Lys Gly Asp Arg Asn Leu Asn Asp Met Lys Met Phe Tyr 
                85                  90                  95      


Lys Ser Val Leu Thr Ala Phe Phe Thr Ala Val Asp Ser Leu Arg Asn 
            100                 105                 110         


Lys Tyr Thr His Tyr Ser His Lys Asp Leu Asn Ile Arg Glu Ile Lys 
        115                 120                 125             


Ile Glu Cys Thr Leu Gly Gly Lys Asp Tyr Cys Ile Gly Leu Leu Asn 
    130                 135                 140                 


Ala Leu Asp Cys Ile Tyr Asp Ser Ala Val Asn Leu Leu Lys Leu Arg 
145                 150                 155                 160 


Phe Met Ala Asp Glu Asp Glu Val Ala His Leu Arg Arg Cys Lys Ala 
                165                 170                 175     


Val Asn Lys Lys Val Val Val Arg Thr Glu Lys Asp Gly Phe Tyr Tyr 
            180                 185                 190         


Arg Leu Ser Asp Asn Gly Glu Val Thr Glu Lys Gly Val Ile Phe Ile 
        195                 200                 205             


Ala Ser Met Phe Leu Asn Arg Lys Tyr Gly Phe Leu Phe Leu Lys Gln 
    210                 215                 220                 


Leu Glu Gly Phe Lys Arg Ser Asp Glu Lys Arg Tyr Arg Leu Thr Leu 
225                 230                 235                 240 


Glu Ala Phe Leu Ala Phe Ser Asn Ile Lys Pro Val Asp Arg Leu Lys 
                245                 250                 255     


Ser Asp Lys Leu Asp Arg Ala Ser Leu Gly Leu Asp Met Leu Asn Glu 
            260                 265                 270         


Leu Thr Lys Ile Pro Lys Glu Leu Ser Glu Thr Leu Ser Val Asp Cys 
        275                 280                 285             


Leu Tyr Lys Tyr Leu Ala Ser Asp Gly Glu Asp Asp Leu Arg Ser Arg 
    290                 295                 300                 


Ile Arg Tyr Gln Asp Arg Phe Val Pro Leu Ala Leu Glu Phe Ile Ser 
305                 310                 315                 320 


Gln Ser Asp Glu Phe Lys Asp Phe Arg Phe Tyr Thr Tyr Val Gly Asn 
                325                 330                 335     


Tyr Val Tyr Lys Gly Tyr Ile Lys Arg Leu Ile Asp Gly Thr Asp Lys 
            340                 345                 350         


Glu Arg Tyr Leu Ser Asp Arg Leu Cys Gly Phe Tyr Lys Ser Val Asn 
        355                 360                 365             


Asp Ala Ser Ser Asp Ala Ile Ala Gln Lys Tyr Gly Val Glu Ile Lys 
    370                 375                 380                 


Asp Ser Asn Glu Pro Asp Tyr Met Leu Pro Asp Ser Phe Arg Pro His 
385                 390                 395                 400 


Val Leu Arg Ala Thr Pro His Phe Val Ile Asn Asn Asn Asn Ile Gly 
                405                 410                 415     


Ile Lys Ile Cys Gly Asn Asp Cys Leu Pro Val Val Asn Gly Lys Gly 
            420                 425                 430         


Val Glu Ser Pro Glu Pro Asp Tyr Trp Leu Ser Ile Tyr Glu Leu Pro 
        435                 440                 445             


Ala Met Leu Phe Tyr Ala Tyr Leu Arg Glu Lys Asn Gly Lys Leu Leu 
    450                 455                 460                 


Lys Asp Tyr Lys Ser Ile Arg Glu Leu Ile Glu Asp Val Glu Lys Lys 
465                 470                 475                 480 


Ala Asp Glu Lys Asn Asp Arg Asp Lys Gly Ala Leu Met Ala Arg His 
                485                 490                 495     


Ile Asp Lys Glu Ile Ile Trp Thr Gln Thr Lys Leu Asp Glu Val Lys 
            500                 505                 510         


Arg Leu Glu Glu Lys Lys Val Ala Ala Tyr Gly Lys Lys Gly Arg Val 
        515                 520                 525             


Val Leu Lys Ser Gly Arg Met Ala Asp Leu Leu Ala His Asp Met Val 
    530                 535                 540                 


Arg Leu Gln Pro Ala Thr Lys Gly Ser Asp Lys Ile Thr Gly Ala Asn 
545                 550                 555                 560 


Phe Gln Ala Leu Gln Val Ser Leu Ala Tyr Phe Lys Arg Asp Ile Leu 
                565                 570                 575     


Ala Asp Val Phe Ser Arg Ala Met Leu Thr Thr Gly Asn His Arg His 
            580                 585                 590         


Pro Phe Leu Tyr Arg Ile Asp Val Ser His Cys Ser Ser Leu Arg Asp 
        595                 600                 605             


Phe Tyr Val Ala Tyr Leu Gly Glu Arg Arg Lys Tyr Phe Glu Asp Val 
    610                 615                 620                 


Ala Lys Lys Ile Thr Lys Asn Lys Leu Asn Thr Pro Cys His Ile Leu 
625                 630                 635                 640 


Arg Arg Leu Gln Arg Glu Gly Ser Gly Glu Glu Ala Gly Lys Asp Val 
                645                 650                 655     


Lys Pro Lys Phe Leu Pro Arg Gly Ile Phe Thr Gly Ser Ile Lys Ser 
            660                 665                 670         


Cys Leu Glu Lys Ser Ala Leu Asn Ile Asn Ile Arg Asn Ala Arg Asn 
        675                 680                 685             


Asp Val Lys Pro Ala Ile Asn Ala Ala Tyr Leu Ile Phe Met Tyr Tyr 
    690                 695                 700                 


Lys Glu Ile Glu Lys Gly Glu Phe Gln Gly Phe Tyr Gly Glu Lys Arg 
705                 710                 715                 720 


Arg Tyr Asp Ile Leu Glu Glu Gly Lys Pro Leu Asp Leu Asp Glu Arg 
                725                 730                 735     


Lys Lys Ala Leu Ala Ser Ile Lys Pro Ala Lys Ile Asp Val Ser Glu 
            740                 745                 750         


Ala Asn Met Pro Met Ser Lys Glu Glu His Leu Met Arg Lys Arg Tyr 
        755                 760                 765             


His Ala Val Cys Asn Asn Glu Ser Ala Ile Arg Met Tyr Gln Val Gln 
    770                 775                 780                 


Asp Ile Leu Leu Leu Leu Met Ala Lys Asp Ile Phe Lys Lys Ala Leu 
785                 790                 795                 800 


Ser Glu Val Val Met Ser Lys Lys Ile Gly Leu Glu Asn Leu Asn Gly 
                805                 810                 815     


Ile Phe Asp Ala Pro Val Asn Phe Val Lys Asn Phe Asp Asn Ile Lys 
            820                 825                 830         


Leu Thr Ala Thr Gly Ile Lys Ile Lys Asp Tyr Gly Lys Val Cys Arg 
        835                 840                 845             


Leu Gly Thr Asp Phe Lys Phe Asn Ser Leu Ile Lys Ala Phe His Lys 
    850                 855                 860                 


Val Tyr Ser Lys Ser Val Glu Met Asp Tyr Ser Asp Tyr Leu Lys Glu 
865                 870                 875                 880 


Glu Glu Glu Phe Glu Lys Tyr Arg Leu Asn Met Val Lys Leu Cys Arg 
                885                 890                 895     


Glu Val Glu Arg Gly Ile Thr Glu Asp Leu His Leu Ser Leu Asp Gly 
            900                 905                 910         


Lys Ser His Leu Ser Phe Asn Asp Asp Val Ile Lys Ser Tyr Asn Asp 
        915                 920                 925             


Lys Tyr Asn Val Phe Asn Gly Asp Asp Leu Thr Phe Phe Ile Asn Ala 
    930                 935                 940                 


Arg Asn Met Phe Met His Gly Asp Tyr Lys Tyr Glu Cys Val Lys Tyr 
945                 950                 955                 960 


Val Val Ser Glu His Phe Lys Gly Ser Leu Asn Asp Val Ser Phe Ala 
                965                 970                 975     


Lys Glu Thr Tyr Gly His Phe Cys Asn Leu Leu Glu Ser Met Arg Lys 
            980                 985                 990         


Lys Thr Gly Leu Arg Ile Asp Ile  
        995                 1000 


<210>  1749
<211>  1094
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1749

Met Glu Ala Asn Glu Gln Asn Gln Glu Asn Arg Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Asn Asn His Ile Ala Ala Asp Phe Gly Gln Ala Val 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ser Gly Phe Leu Cys Asn Lys Glu 
    50                  55                  60                  


Ile Lys Lys Leu Asn Trp Asn His Ile Tyr Ala Lys Thr Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ile Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Val Asn Ser Asp Lys Glu Gly Lys Asp Phe Ala Ala Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Ser Glu Leu Gln Asp Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Glu Asn Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Ala Glu Leu Thr Asp Met Leu Thr Ile Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Thr Asp Ala Asp Tyr 
                165                 170                 175     


Glu Leu Val Glu Thr Lys Gln Val Val Thr Thr Gly Asn Ile Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Met Phe Leu Glu Arg Glu His 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asn Leu Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Gly 
            260                 265                 270         


Val Ile Thr Asp Glu Glu Lys Met Gln Phe Arg Pro Glu Leu Asp Glu 
        275                 280                 285             


Leu Asp Ile Glu Lys Leu Ile Ala Asn Ser Thr Asn Asp Asp Glu Arg 
    290                 295                 300                 


Glu Arg Ile Leu Asp Glu Ile Gly Tyr Glu Glu Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg Tyr Asn Asn Arg Phe Pro Tyr Phe Ala Met Arg 
                325                 330                 335     


Phe Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Arg Tyr Thr Lys Gln Leu Ala Gly Glu 
        355                 360                 365             


Gln Thr Glu Arg Val Val Gln Glu Asn Val Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asp Pro Glu Leu Ile Gln Gln Lys Ile Asp Asn Gln 
385                 390                 395                 400 


Gln Arg Thr Asp Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Ile Ala Ile Leu Ile 
            420                 425                 430         


Pro Lys Ser Lys Pro Glu Ser Lys Val Gly Asn Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Asp Tyr Leu Gln Lys Gly Lys Ala Glu Glu Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Ile Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Leu Lys Leu Pro Ala Asn Trp Asn Glu Phe Ala Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asp Ala Ala Met Glu Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Asp Val Leu Ile Thr Tyr Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Asp Val Glu Asp Asn Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Leu Glu Lys His Lys Leu 
            580                 585                 590         


Asp Lys Ser Val Lys Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Met Val Ser Lys Glu Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Ala Asp Thr Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Val Leu Glu Gly Asp Gly His Pro Phe Leu Thr Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Glu Leu Tyr Met Asn 
        675                 680                 685             


Ala Lys Val Gln Tyr Leu Ile Gln Phe Tyr Lys Pro Ser Lys Asp Lys 
    690                 695                 700                 


Val Asp Lys Arg Gly Arg Pro Thr Thr Glu Val Lys Leu Pro Pro Leu 
705                 710                 715                 720 


Asp Lys Arg Ser Asn Ile Pro Phe Thr Ile Arg Gln Trp Asp Glu Lys 
                725                 730                 735     


Glu Lys Tyr Asn Leu Asn Ala Trp Leu Arg Asn Val Thr Val Gly Lys 
            740                 745                 750         


Asn Thr Lys Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe 
        755                 760                 765             


Asp Glu Thr Leu Cys Asp Leu Leu Ser Gln Gln Leu Asp Ala Arg Thr 
    770                 775                 780                 


Val Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Leu Trp 
785                 790                 795                 800 


Trp Lys Thr Arg Asp Asp Ala Thr Gln Asp Phe Tyr Gln Ser Glu Arg 
                805                 810                 815     


Glu Tyr Asp Ile Tyr Glu Glu Lys Val Glu Phe Lys Ile Asp Ser Ser 
            820                 825                 830         


Gly His Phe Ala Asp Tyr Tyr Lys Lys Ala Leu Ser Lys Ala Tyr Asn 
        835                 840                 845             


Arg Leu Lys Ala Glu Arg Glu Ile Ala Arg Arg Thr Asn Lys Arg Leu 
    850                 855                 860                 


Pro Pro Ile Glu His Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile 
865                 870                 875                 880 


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
                885                 890                 895     


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asp Ser Gly Asn Leu Lys 
            900                 905                 910         


Leu Ser Thr Ile Lys Thr Ser Leu Asn Asn Thr Thr Gln Ile Lys Gln 
        915                 920                 925             


Lys Ile Leu Asn Lys Thr Ile Val Ala Glu Arg Lys Gln Lys Asn Tyr 
    930                 935                 940                 


Thr Glu Leu Arg Lys Tyr Val His Asp Arg Arg Leu Pro Asn Leu Phe 
945                 950                 955                 960 


Glu Tyr Val Glu Ala Asp Glu Ile Leu Leu Glu Trp Leu Leu Asp Glu 
                965                 970                 975     


Leu Met Ala Tyr Asn Ala Ala Lys Gln Gln Val Phe Asp Thr Ile Phe 
            980                 985                 990         


Met Leu Glu Lys Arg Ile Ile Glu  Thr Asp Pro Gln Glu  Leu Lys Ser 
        995                 1000                 1005             


Leu Phe  Thr Asn Glu Lys Gly  Gln Val Gln Thr Gly  Asn Ile Gln 
    1010                 1015                 1020             


His Lys  Pro Tyr Val Gln Trp  Leu Lys Asn Lys Gly  Leu Ile Asn 
    1025                 1030                 1035             


His Asn  Glu Lys Leu Phe Ile  Asn Met Val Arg Asn  Cys Phe Ser 
    1040                 1045                 1050             


His Asn  Gln Phe Pro Gln Arg  Glu Thr Met Glu Leu  Leu Ile Ser 
    1055                 1060                 1065             


Glu Trp  Gly Ala Gly Lys Ile  Ala Thr Gln Ile Leu  Thr Val Tyr 
    1070                 1075                 1080             


Asn Gln  Leu Ile Thr Asn Ile  Ile Asn Lys Ile 
    1085                 1090                 


<210>  1750
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1750

Met Glu Thr Lys Gln Gln Val Gly Lys Gly Ile Ser Tyr Asp His Arg 
1               5                   10                  15      


Arg Pro Asp Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asp Gly Val Ile Gln Glu Phe Ala Met Arg Leu Asn Arg 
        35                  40                  45              


Glu Tyr Asp Pro Glu Asn Lys Asn Gln Ser Leu Phe Ser Tyr Phe Asn 
    50                  55                  60                  


Ile Asn Ala Ser Phe Thr Asp Trp Glu Arg Gly Val Asn Ile Leu Lys 
65                  70                  75                  80  


Glu Tyr Trp Pro Met Met Glu Phe Ile Asp Arg Pro Ala Thr Asp Lys 
                85                  90                  95      


Gln Phe Glu Ala Glu Lys Pro Glu Asn Arg Glu Ala Ala Lys Arg Lys 
            100                 105                 110         


Tyr Phe Leu Ala Thr Leu Gly Ala Leu Leu Thr Ser Ile Lys Asp Leu 
        115                 120                 125             


Arg His Tyr Tyr Thr His Tyr Tyr His Pro Pro Val His Leu Asn Asp 
    130                 135                 140                 


Asp Leu Phe Leu Phe Leu Asp His Ala Leu Leu Tyr Thr Ala Phe Asp 
145                 150                 155                 160 


Val Lys Lys Thr Lys Met Lys Asp Asp Lys Thr Arg Gln Leu Leu Asn 
                165                 170                 175     


Gln Asn Leu Ser Leu Glu Leu Glu Lys Leu Lys Lys Leu Lys Val Glu 
            180                 185                 190         


Glu Leu Lys Lys Lys Lys Glu Lys Gly Ile Lys Val Asn Leu Gln Asp 
        195                 200                 205             


Glu Lys Gly Ile Leu Asn Ala Ile Tyr Asn Asp Ala Phe Ala His Ile 
    210                 215                 220                 


Ile Thr Lys Glu Lys Asp Ser Asp Lys Asp Lys Leu Glu Thr Arg Tyr 
225                 230                 235                 240 


Lys Ser Ile Leu Pro Gln Asp Glu Ala Ala Glu Thr Gly Ile Asn Ile 
                245                 250                 255     


Ser Ile Ser Gly Leu Ile Phe Leu Leu Ser Leu Phe Leu Ser Arg Lys 
            260                 265                 270         


Glu Ile Glu Gln Leu Lys Ser Asn Ile Glu Gly Tyr Lys Gly Lys Val 
        275                 280                 285             


Leu Asn Ile Glu Thr Glu Val Asp Arg Lys His Asn Ser Leu Lys Tyr 
    290                 295                 300                 


Met Ala Thr His Trp Val Phe Ser Ile Leu Ala Phe Lys Gly Leu Lys 
305                 310                 315                 320 


Gln Arg Leu Thr Asn Ser Phe Glu Lys Glu Ser Leu Leu Ile Gln Met 
                325                 330                 335     


Met Asp Glu Leu Asn Lys Val Pro Asp Glu Leu Tyr Gln Thr Leu Ser 
            340                 345                 350         


Glu Thr Ala Lys Lys Glu Phe Leu Glu Asp Ile Asn Glu Tyr Val Ser 
        355                 360                 365             


Glu Gly Asp Asp Asn Glu Lys Ala Thr Tyr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Ser Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gln Phe Pro Thr Leu Lys Phe Gln Ile Phe Val Gly 
                405                 410                 415     


Gln Tyr Leu His Asp Asn Arg Pro Lys Thr Leu Ala Ser Asn Gly Met 
            420                 425                 430         


Thr Ala Gln Arg Met Ile Lys Glu Lys Ile Asn Leu Phe Gly Asn Leu 
        435                 440                 445             


Ser Glu Val Thr Lys His Lys Ser Asp Phe Phe Glu Lys Glu Ser Ala 
    450                 455                 460                 


Ala Gln Gly Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Trp Ala Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Val Tyr Ile Asp Met Ile Gly Lys Glu Gly Lys Ala 
                485                 490                 495     


Lys Glu Ile Gln Val Gln Ile Asn Lys Tyr Arg Lys Gln Leu Asn Pro 
            500                 505                 510         


Ala Pro Gln Arg Asp Lys Arg Ile Ser Lys Lys Glu Ile Ile Glu Gln 
        515                 520                 525             


Leu Tyr Lys Glu Lys Val Val Tyr Gly Asp Pro Thr Leu Met Leu Ser 
    530                 535                 540                 


Ala Asn Glu Leu Met Ala Leu Leu Tyr Glu Leu Ile Val Asn Gly Lys 
545                 550                 555                 560 


Ser Gly Ala Glu Leu Glu Asn Lys Ile Val Glu Gln Ile Ile Ala Arg 
                565                 570                 575     


Tyr Glu Gln Ile Glu Ala Tyr Asp Pro Thr Thr Gln Gln Leu Pro Thr 
            580                 585                 590         


Asn Gln Met Pro His Lys Leu Gln Lys Ser Arg Lys Asp Ser Lys Val 
        595                 600                 605             


Thr Asp Thr Asp Lys Leu Leu Lys Thr Ile Asp Lys Glu Ile Asp Glu 
    610                 615                 620                 


Gly Asn Lys Lys Leu Glu Leu Ile Ala Cys His Arg Lys Glu Trp Glu 
625                 630                 635                 640 


Glu Ala Glu Gln Arg Lys Lys Ser Gly Lys Arg Asn Asn Pro Gly Thr 
                645                 650                 655     


Lys Ser Arg Lys His Leu Phe Tyr Ala Ser Glu Met Gly Glu Glu Ala 
            660                 665                 670         


Thr Trp Ile Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Pro Ala Arg 
        675                 680                 685             


Ala Glu Trp Lys Gly Thr His His Ser Glu Leu Gln Arg Leu Leu Ala 
    690                 695                 700                 


Phe Tyr Ser Thr Gln Arg Leu Glu Ala Trp Gln Leu Val Glu Ser Val 
705                 710                 715                 720 


Trp Thr Ala Asn Thr His Ser Phe Trp Glu Glu Asn Phe Lys Glu Ala 
                725                 730                 735     


Phe Tyr Lys Pro Glu Phe Glu Asn Phe Tyr Gly Ala Tyr Ile Glu Ile 
            740                 745                 750         


Arg Thr Lys Ile Leu Thr Thr Cys Arg Ser Ile Leu Glu Asn Asn Pro 
        755                 760                 765             


Glu Ala Thr Met Asn Asn Asp Thr Glu Lys Glu Trp Asp Lys Val Phe 
    770                 775                 780                 


Thr Leu Phe Asp Lys Arg Leu Tyr Arg Thr Ser Thr Thr Asp Glu Gln 
785                 790                 795                 800 


Lys Lys Gln Leu Leu Thr Lys Pro Phe Ala Phe Pro Arg Gly Leu Phe 
                805                 810                 815     


Asp Asp Lys Pro Thr Phe Leu Pro Gly Ser Lys Pro Asn Glu Asn Pro 
            820                 825                 830         


Glu Arg Phe Ala Ala Trp Tyr Ser Tyr Gly Tyr Thr Tyr Ser Gly Lys 
        835                 840                 845             


Phe Gln Ser Phe Tyr Asp Met Pro Arg Asn Tyr Ser Asp Trp Tyr Lys 
    850                 855                 860                 


Lys Leu Lys Glu Asp Gly Lys Leu Pro Arg Leu Asp Lys Lys Thr Glu 
865                 870                 875                 880 


Gln Glu Lys Ile Leu Arg Phe Arg Met Asp Cys Asp Leu Asn Ile Lys 
                885                 890                 895     


His Ile Arg Phe Gln Asp Ile Tyr Val Lys Leu Met Val Asp Ser Leu 
            900                 905                 910         


Tyr Lys Ala Val Phe Gly Gln Gln Pro Glu Phe Asp Leu Ser His Leu 
        915                 920                 925             


Tyr Asp Thr Arg Ser Glu Arg Tyr Glu Asn Asn Thr Ile Ala Gln Arg 
    930                 935                 940                 


Gln Lys Ser Arg Gln Glu Gly Asp Asn Ser Asp Asn Ala Ile Asn Glu 
945                 950                 955                 960 


Asn Tyr Val Trp Asn Lys Thr Phe Ala Ile Ser Leu Tyr Asn Gly Arg 
                965                 970                 975     


Ile Thr Glu Ser Gln Val Lys Leu Lys Asp Val Gly Lys Phe Arg Arg 
            980                 985                 990         


Phe Ala Thr Asp Pro Arg Val Gln  Thr Leu Ile Ser Tyr  Asp Asp Thr 
        995                 1000                 1005             


Arg Thr  Trp Thr Lys Leu Glu  Ile Glu Asn Glu Leu  Asp Asn Lys 
    1010                 1015                 1020             


Ala Asp  Ala Tyr Glu Pro Ile  Arg Arg Thr Gln Ser  Leu Lys Ala 
    1025                 1030                 1035             


Ile Gln  Gln Leu Glu Lys Asn  Ile Leu Lys Lys Asn  Gly Phe Asn 
    1040                 1045                 1050             


Gly Lys  Gln His Pro Glu Glu  Leu Lys His Asn Gly  Asn Pro Asn 
    1055                 1060                 1065             


Phe Arg  Lys Tyr Ile Ala Asn  Gly Leu Leu Lys His  Arg Thr Asp 
    1070                 1075                 1080             


Ile Arg  Gln Glu Glu Leu Ala  Leu Ile Ser Asp Thr  Glu Phe Gln 
    1085                 1090                 1095             


Glu Ile  Gly Leu Glu Arg Ile  Arg Gln Thr Asn Pro  Leu Ile Gln 
    1100                 1105                 1110             


Lys Ala  Tyr Leu Leu Ile Leu  Leu Arg Asn Lys Phe  Gly His Asn 
    1115                 1120                 1125             


Gln Leu  Pro Asp Gln Glu His  Phe Arg Leu Met Arg  Ser Ile Tyr 
    1130                 1135                 1140             


Pro Tyr  Asn Gln Gln Glu Ser  Tyr Ser Ala Tyr Phe  Asn His Val 
    1145                 1150                 1155             


Ile Thr  Gln Ile Ile Glu Glu  Leu Asn Thr 
    1160                 1165             


<210>  1751
<211>  1000
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1751

Met Glu Glu Ala Asn Arg Tyr Ile Tyr Gly Ala Tyr Phe Asn Met Ala 
1               5                   10                  15      


Arg Asp Asn Phe Leu Asn Thr Ile Lys Leu Leu Ala Asp Lys Met Lys 
            20                  25                  30          


Leu Gly Ala Thr Ser Gly Phe Gly Lys Asp Gly Asn Glu Val Asn Asp 
        35                  40                  45              


Ile Asn Glu Leu Phe Gly Asp Lys Asn Thr Tyr Ala Asn Ile Glu Asn 
    50                  55                  60                  


Val Val Glu Phe Tyr Phe Pro Trp Ile Lys Ala Leu Glu Gly Arg Phe 
65                  70                  75                  80  


Ser Leu Asp Lys Gly Asp Arg Asn Leu Asn Asp Met Lys Met Phe Tyr 
                85                  90                  95      


Lys Ser Val Leu Thr Ala Phe Phe Thr Ala Val Asp Ser Leu Arg Asn 
            100                 105                 110         


Lys Tyr Thr His Tyr Ser His Lys Asp Leu Asn Ile Arg Glu Ile Lys 
        115                 120                 125             


Ile Glu Cys Thr Leu Gly Gly Lys Asp Tyr Cys Ile Gly Leu Leu Asn 
    130                 135                 140                 


Ala Leu Asp Cys Ile Tyr Asp Ser Ala Val Asn Leu Leu Lys Leu Arg 
145                 150                 155                 160 


Phe Met Ala Asp Glu Asp Glu Val Ala His Leu Arg Arg Cys Lys Ala 
                165                 170                 175     


Val Asn Lys Lys Val Val Val Arg Thr Glu Lys Asp Gly Phe Tyr Tyr 
            180                 185                 190         


Arg Leu Ser Asp Asn Gly Glu Val Thr Glu Lys Gly Val Ile Phe Ile 
        195                 200                 205             


Ala Ser Met Phe Leu Asn Arg Lys Tyr Gly Phe Leu Phe Leu Lys Gln 
    210                 215                 220                 


Leu Glu Gly Phe Lys Arg Ser Asp Glu Lys Arg Tyr Arg Leu Thr Leu 
225                 230                 235                 240 


Glu Ala Phe Leu Ala Phe Ser Asn Ile Lys Pro Val Asp Arg Leu Lys 
                245                 250                 255     


Ser Asp Lys Leu Asp Arg Ala Ser Leu Gly Leu Asp Met Leu Asn Glu 
            260                 265                 270         


Leu Thr Lys Ile Pro Lys Glu Leu Ser Glu Thr Leu Ser Val Asp Cys 
        275                 280                 285             


Leu Tyr Lys Tyr Leu Ala Ser Asp Gly Glu Asp Asp Leu Arg Ser Arg 
    290                 295                 300                 


Ile Arg Tyr Gln Asp Arg Phe Val Pro Leu Ala Leu Glu Phe Ile Ser 
305                 310                 315                 320 


Gln Ser Asp Glu Phe Lys Asp Phe Arg Phe Tyr Thr Tyr Val Gly Asn 
                325                 330                 335     


Tyr Val Tyr Lys Gly Tyr Ile Lys Arg Leu Ile Asp Gly Thr Asp Lys 
            340                 345                 350         


Glu Arg Tyr Leu Ser Asp Arg Leu Cys Gly Phe Tyr Lys Ser Val Asn 
        355                 360                 365             


Asp Ala Ser Ser Asp Ala Ile Ala Gln Lys Tyr Gly Val Glu Ile Lys 
    370                 375                 380                 


Asp Ser Asn Glu Pro Asp Tyr Met Leu Pro Asp Ser Phe Arg Pro His 
385                 390                 395                 400 


Val Leu Arg Ala Thr Pro His Phe Val Ile Asn Asn Asn Asn Ile Gly 
                405                 410                 415     


Ile Lys Ile Cys Gly Asn Asp Cys Leu Pro Val Val Asn Gly Lys Gly 
            420                 425                 430         


Val Glu Ser Pro Glu Pro Asp Tyr Trp Leu Ser Ile Tyr Glu Leu Pro 
        435                 440                 445             


Ala Met Leu Phe Tyr Ala Tyr Leu Arg Glu Lys Asn Gly Lys Leu Leu 
    450                 455                 460                 


Lys Asp Tyr Lys Ser Ile Arg Glu Leu Ile Glu Asp Val Glu Lys Lys 
465                 470                 475                 480 


Ala Asp Glu Lys Asn Asp Arg Asp Lys Gly Ala Leu Met Ala Arg His 
                485                 490                 495     


Ile Asp Lys Glu Ile Ile Trp Thr Gln Thr Lys Leu Asp Glu Val Lys 
            500                 505                 510         


Arg Leu Glu Glu Lys Lys Val Ala Ala Tyr Gly Lys Lys Gly Arg Val 
        515                 520                 525             


Val Leu Lys Ser Gly Arg Met Ala Asp Leu Leu Ala His Asp Met Val 
    530                 535                 540                 


Arg Leu Gln Pro Ala Thr Lys Gly Ser Asp Lys Ile Thr Gly Ala Asn 
545                 550                 555                 560 


Phe Gln Ala Leu Gln Val Ser Leu Ala Tyr Phe Lys Arg Asp Ile Leu 
                565                 570                 575     


Ala Asp Val Phe Ser Arg Ala Met Leu Thr Thr Gly Asn His Arg His 
            580                 585                 590         


Pro Phe Leu Tyr Arg Ile Asp Val Ser His Cys Ser Ser Leu Arg Asp 
        595                 600                 605             


Phe Tyr Val Ala Tyr Leu Gly Glu Arg Arg Lys Tyr Phe Glu Asp Val 
    610                 615                 620                 


Ala Lys Lys Ile Thr Lys Asn Lys Leu Asn Thr Pro Cys His Ile Leu 
625                 630                 635                 640 


Arg Arg Leu Gln Arg Glu Gly Ser Gly Glu Glu Ala Gly Lys Asp Val 
                645                 650                 655     


Lys Pro Lys Phe Leu Pro Arg Gly Ile Phe Thr Gly Ser Ile Lys Ser 
            660                 665                 670         


Cys Leu Glu Lys Ser Ala Leu Asn Ile Asn Ile Arg Asn Ala Arg Asn 
        675                 680                 685             


Asp Val Lys Pro Ala Ile Asn Ala Ala Tyr Leu Ile Phe Met Tyr Tyr 
    690                 695                 700                 


Lys Glu Ile Glu Lys Gly Glu Phe Gln Gly Phe Tyr Gly Glu Lys Arg 
705                 710                 715                 720 


Arg Tyr Asp Ile Leu Glu Glu Gly Lys Pro Leu Asp Leu Asp Glu Arg 
                725                 730                 735     


Lys Lys Ala Leu Ala Ser Ile Lys Pro Ala Lys Ile Asp Val Ser Glu 
            740                 745                 750         


Ala Asn Met Pro Met Ser Lys Glu Glu His Leu Met Arg Lys Arg Tyr 
        755                 760                 765             


His Ala Val Cys Asn Asn Glu Ser Ala Ile Arg Met Tyr Gln Val Gln 
    770                 775                 780                 


Asp Ile Leu Leu Leu Leu Met Ala Lys Asp Ile Phe Lys Lys Ala Leu 
785                 790                 795                 800 


Ser Glu Val Val Met Ser Lys Lys Ile Gly Leu Glu Asn Leu Asn Gly 
                805                 810                 815     


Ile Phe Asp Ala Pro Val Asn Phe Val Lys Asn Phe Asp Asn Ile Lys 
            820                 825                 830         


Leu Thr Ala Thr Gly Ile Lys Ile Lys Asp Tyr Gly Lys Val Cys Arg 
        835                 840                 845             


Leu Gly Thr Asp Phe Lys Phe Asn Ser Leu Ile Lys Ala Phe His Lys 
    850                 855                 860                 


Val Tyr Ser Lys Ser Val Glu Met Asp Tyr Ser Asp Tyr Leu Lys Glu 
865                 870                 875                 880 


Glu Glu Glu Phe Glu Lys Tyr Arg Leu Asn Met Val Lys Leu Cys Arg 
                885                 890                 895     


Glu Val Glu Arg Gly Ile Thr Glu Asp Leu His Leu Ser Leu Asp Gly 
            900                 905                 910         


Lys Ser His Leu Ser Phe Asn Asp Asp Val Ile Lys Ser Tyr Asn Asp 
        915                 920                 925             


Lys Tyr Asn Val Phe Asn Gly Asp Asp Leu Thr Phe Phe Ile Asn Ala 
    930                 935                 940                 


Arg Asn Met Phe Met His Gly Asp Tyr Lys Tyr Glu Cys Val Lys Tyr 
945                 950                 955                 960 


Val Val Ser Glu His Phe Lys Gly Ser Leu Asn Asp Val Ser Phe Ala 
                965                 970                 975     


Lys Glu Thr Tyr Gly His Phe Cys Asn Leu Leu Glu Ser Met Arg Lys 
            980                 985                 990         


Lys Thr Gly Leu Arg Ile Asp Ile  
        995                 1000 


<210>  1752
<211>  1351
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1752

Met Glu Lys Glu Asn Lys Lys Gly Asp Asn Asp Thr Gln Asn Gln Asn 
1               5                   10                  15      


Lys Ser Thr Pro Pro Ala Lys Lys Phe Met Leu Ile Asn Glu Asn Arg 
            20                  25                  30          


Gly Lys His Ile Ala Gly Thr Tyr Phe Glu Met Ala Leu Ala Asn Met 
        35                  40                  45              


Ile Arg Thr Ile Glu His Val Phe Ile Arg Ala His Val Tyr Ser Ile 
    50                  55                  60                  


Val Gly Lys Leu Gln Glu Asp Thr Met Ala Asp Thr Ile Glu His Leu 
65                  70                  75                  80  


Ala Lys Gln Asn Leu Ser Ala Thr Gln Lys Ser Thr Leu Ser Arg Leu 
                85                  90                  95      


Ile Phe Arg His Met Pro Phe Phe Gly Pro Leu Met Ala Asp Ala Val 
            100                 105                 110         


Asp Thr Ala Ile Tyr Pro Leu Arg Lys Lys Leu Lys Glu Leu Glu Glu 
        115                 120                 125             


Arg Arg Asp Glu Ile Asn Lys Glu Leu Gln Asn Lys Asn Asn Asn Lys 
    130                 135                 140                 


Arg Gln Glu Leu Glu Val Glu Lys Gln Thr Leu Lys Lys Thr Ile Lys 
145                 150                 155                 160 


Ala Thr Arg Lys Ala Leu Glu Gln Gln Ile Val Gly Ser Ser Pro Gln 
                165                 170                 175     


Leu Met Val Glu Tyr Leu Ser Thr Met Ser Arg Met Met Val Thr Leu 
            180                 185                 190         


Arg Asn Phe Tyr Ser His Lys Asn Pro Tyr Ser Asn Lys Glu Asp Tyr 
        195                 200                 205             


Glu Lys Gln Lys Ser Asp Ser Lys Lys Leu Ala Gln Trp Leu Glu Ile 
    210                 215                 220                 


Ile Phe Lys Gly Glu Arg Gly Ile Leu Leu Glu Arg Lys Thr His Ser 
225                 230                 235                 240 


Gln Glu Asp Thr Lys Phe Leu Thr Gln Asp Gly Val Leu Asn Tyr Asn 
                245                 250                 255     


Val Asn Lys Asn Asn Lys Ser Thr Arg Asn Asn Asp Phe Tyr Phe Gly 
            260                 265                 270         


Pro Gly Lys Lys Thr Asp Lys Gly Trp Glu Leu Thr Asp Phe Gly Arg 
        275                 280                 285             


Tyr Phe Phe Val Ser Leu Phe Leu Arg Lys Val Asp Ala Asp Arg Phe 
    290                 295                 300                 


Ala Lys Asp Val Cys Leu Tyr Ile Asp Ser Pro Phe Arg Leu Thr Val 
305                 310                 315                 320 


Glu Lys Lys Leu Gln Leu Gln Gln Lys Glu Asn Leu Arg Ala Met Lys 
                325                 330                 335     


Glu Gln Phe Ile Ala Asp Glu Asn Gly Glu Asp Arg Ile Val Asn Pro 
            340                 345                 350         


Arg Ile Ile Gly Asp Thr Glu Ser Cys Gln Asn Asn Ile Ile Arg Glu 
        355                 360                 365             


Met Leu Asp Met His Arg Ile His Ile Pro Arg Glu Lys Arg Ile Asp 
    370                 375                 380                 


Ala Glu Ile Thr Glu Gly Ile Leu Val Met Asp Ala Leu Asn Glu Leu 
385                 390                 395                 400 


Arg Lys Cys Pro Lys Val Ile His Asp Thr Phe Ser Pro Ser Asp Lys 
                405                 410                 415     


Glu Asn Phe Ile Thr Lys Gly Glu Thr Pro Asn Gly Glu Ile Val Glu 
            420                 425                 430         


Ser Lys Leu Val Arg Pro Gln Asp Arg Phe Val Asp Leu Ala Leu Arg 
        435                 440                 445             


Cys Ile Asp Gln Glu Glu Val Phe Thr Asp Ile Arg Phe His Leu Arg 
    450                 455                 460                 


Leu Gly Leu Phe Arg Tyr Arg Phe Tyr Pro Lys Glu Thr Ile Asp Gly 
465                 470                 475                 480 


Ser Tyr Val Glu Pro Ile Arg Thr Ile Gln Lys Glu Ile Asn Gly Phe 
                485                 490                 495     


Gly Arg Met Asn Asp Val Glu Lys Leu Arg Asp Asp Lys Tyr Arg Thr 
            500                 505                 510         


Ser Phe Gln Leu Arg Thr Ile Asn Glu Asp Gly Leu Glu Gln Pro Val 
        515                 520                 525             


Pro Asp Ser Lys Asp Ser Gln Pro Tyr Ile Thr Asp Trp Arg Thr Thr 
    530                 535                 540                 


Tyr Asn Ile His Ala Asn Arg Ile Gly Leu Ala Trp Gly Leu Pro Gln 
545                 550                 555                 560 


Met Thr Gly Gly Tyr Tyr Leu Pro Asp Leu Asn Thr Asp Glu Glu Asp 
                565                 570                 575     


Asn Gln Asn Arg Lys Ala Ile Ile Asp Met Pro Ser Pro Met Cys Tyr 
            580                 585                 590         


Leu Ser Thr Tyr Asp Leu Pro Ala Leu Leu Phe Tyr Arg His Ile Phe 
        595                 600                 605             


Asn Leu Tyr His Gly Thr Lys Tyr Ser Lys Asp Gly Ile Val Asp Ala 
    610                 615                 620                 


Gln Thr Val Ile Lys Gln Lys Tyr Asp Ala Leu His Asp Phe Phe Ile 
625                 630                 635                 640 


Ala Val Ser Ser Ser Glu Leu Ser Thr Glu Glu Leu Leu Glu Lys Gln 
                645                 650                 655     


Lys Glu Leu Lys Ile Ala Asp Glu Asp Leu Pro Asp Lys Leu Arg Cys 
            660                 665                 670         


Phe Leu Gly Thr Lys Lys Leu Phe Asn Lys Lys Gly Lys Pro Ile Leu 
        675                 680                 685             


Lys Lys Thr Asp Ser Gly Glu Lys Val Gln Ile Ile Lys Glu Trp Arg 
    690                 695                 700                 


Ala Asn Asp Glu Lys Lys Lys His Ala Ile Asn Thr Leu Leu Glu Val 
705                 710                 715                 720 


Ile Glu Glu Asp Lys Phe Arg Leu Glu Ala Phe Glu Lys Lys His Ser 
                725                 730                 735     


Lys Ile Ile Lys Gly Gly Arg Asp Asn Arg Tyr Gly Arg Arg Gly His 
            740                 745                 750         


Ala Asp Val Arg His Gly Ala Ile Ala Arg Tyr Leu Ala Lys Ser Met 
        755                 760                 765             


Leu Arg Trp Gln Gln Thr Ile Ala Glu Ala Gly Gly Gly Lys Ile Thr 
    770                 775                 780                 


Ser Ser Asp Phe Arg Val Leu Ser Asp Tyr Leu Thr Gly Tyr Gly Ile 
785                 790                 795                 800 


Gly Val Arg Glu Glu Phe Ala Ser Val Ala Leu Tyr Asn Leu Lys Asn 
                805                 810                 815     


Val Leu Lys Lys Ala Lys Leu Ile Asp Ser Gln Asn Glu His Pro Phe 
            820                 825                 830         


Leu Lys Glu Lys Val Leu Ser Ser Ser Pro Met Asn Ile Glu Gln Leu 
        835                 840                 845             


Tyr Thr Thr Tyr Leu Gln Glu Glu Lys Thr His Ala Glu Glu Leu Ile 
    850                 855                 860                 


Ala Lys Ile Asn Asn Asp Asp Lys Asp Ile Asp Leu Pro Pro Phe Thr 
865                 870                 875                 880 


Arg Pro Asn Gly Leu Arg Trp Glu Thr Ser Leu Lys Glu Ala Ala Leu 
                885                 890                 895     


Arg Tyr Thr Glu Thr Pro Ala Ala Pro Phe Asp Glu Thr Gly Ser Ser 
            900                 905                 910         


His Asn Val Ser Ile Leu Leu Pro Asn Gly Leu Phe Thr Pro His Ile 
        915                 920                 925             


Ile Asn Leu Leu Lys Thr Ala Leu Ala Asp Lys Thr Ile Asp Glu His 
    930                 935                 940                 


Lys Ala Leu Ala Pro Met Ser Lys Leu Leu Glu Ser Asn Pro Asn Thr 
945                 950                 955                 960 


Phe Gly Ala Ser Tyr Ile Ile Arg Tyr Trp Phe Asp His Val Ala Gln 
                965                 970                 975     


Asp Gly Pro Gln Ala Phe Tyr Asn Asn Gly Ser His Gln Tyr Lys Arg 
            980                 985                 990         


Tyr His Arg Ala Leu Ser Leu Leu  Asn Pro His Arg Lys  Pro Asn Lys 
        995                 1000                 1005             


Gln Leu  Ile Pro Asp Tyr Phe  Thr Glu Asp Glu Ile  Ala Glu Arg 
    1010                 1015                 1020             


Leu Lys  Tyr Ala Arg Gln Lys  Asn Lys Glu Val Leu  Lys Asp Lys 
    1025                 1030                 1035             


Val Ile  Lys Ala Phe Asn Leu  Asp Ser Lys Lys Thr  Glu Lys Ile 
    1040                 1045                 1050             


Asp Glu  Lys Leu Lys Gln Met  Arg Glu Met Leu Asn  Glu Val Ala 
    1055                 1060                 1065             


Ala Lys  Glu Gln Ser Ile Arg  Arg Tyr Arg Val Gln  Asp Ile Thr 
    1070                 1075                 1080             


Leu Phe  Leu Thr Val Arg Asp  Met Leu Leu Lys Met  Leu Ser Ser 
    1085                 1090                 1095             


Lys Tyr  Asp Glu Arg Lys Lys  Glu Asn Ile Arg Lys  Gln Thr Ile 
    1100                 1105                 1110             


Lys Arg  Ile Ser Lys Met Arg  Leu Gln Asp Phe Gly  Phe Gly Phe 
    1115                 1120                 1125             


Asp Phe  Lys Leu Phe Ala Ala  Thr Asp Asp Asp Ser  Ser Tyr Thr 
    1130                 1135                 1140             


Tyr Glu  His Lys Ser Gly Ile  Lys Ile Lys Met Pro  Ile Leu Ser 
    1145                 1150                 1155             


Leu Asn  Asn Tyr Gly Ser Ile  Phe Arg Ile Leu Ser  Glu Gly Gln 
    1160                 1165                 1170             


Arg Val  Asp Asn Leu Leu Ser  Gly Leu Lys Glu Leu  Gly Ile Thr 
    1175                 1180                 1185             


Glu Val  Tyr Phe Ser Asp Leu  Thr Ala Glu Ile Ala  Glu His Asp 
    1190                 1195                 1200             


Glu Lys  Arg Lys Glu Phe Leu  Lys Ile Ala Gln Asp  Ile Glu Gln 
    1205                 1210                 1215             


Lys Ala  Tyr Asp Gln Asn Tyr  Asp Ile Leu Ser Asn  Asp Arg Asp 
    1220                 1225                 1230             


Pro Gly  Phe Tyr Lys Lys Asp  Ile Ile Tyr Asp Ala  Asn Asn Pro 
    1235                 1240                 1245             


Glu Arg  Ile Leu Asn Pro Ser  Thr Asp Ala Lys Arg  Asn His Phe 
    1250                 1255                 1260             


Ser Asp  Leu Ile Gly Phe Leu  Lys Glu Phe Ser Ser  Phe Leu Ser 
    1265                 1270                 1275             


Phe Lys  Tyr Val Asp Glu Asn  Gly Lys Glu Lys Lys  Ile Asn Leu 
    1280                 1285                 1290             


Ser Glu  Phe Val Lys Glu Leu  Arg Asn Ala Ala Ala  His Asn Arg 
    1295                 1300                 1305             


Tyr Pro  Thr Thr Tyr Ala Phe  Lys Met Leu Lys Glu  His Thr Lys 
    1310                 1315                 1320             


Gly Lys  Thr Ile Lys Val Gln  Asn Ile Ile Asn Met  Ile Leu Glu 
    1325                 1330                 1335             


Met Val  Asn Gln Asp Ile Glu  Glu Met Asn Lys Lys  Gln 
    1340                 1345                 1350     


<210>  1753
<211>  1000
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1753

Met Glu Glu Ala Asn Arg Tyr Ile Tyr Gly Ala Tyr Phe Asn Met Ala 
1               5                   10                  15      


Arg Asp Asn Phe Leu Asn Thr Ile Lys Leu Leu Ala Asp Lys Met Lys 
            20                  25                  30          


Leu Gly Ala Thr Ser Gly Phe Gly Lys Asp Gly Asn Glu Val Asn Asp 
        35                  40                  45              


Ile Asn Glu Leu Phe Gly Asp Lys Asn Thr Tyr Ala Asn Ile Glu Asn 
    50                  55                  60                  


Val Val Glu Phe Tyr Phe Pro Trp Ile Lys Ala Leu Glu Gly Arg Phe 
65                  70                  75                  80  


Ser Leu Asp Lys Gly Asp Arg Asn Leu Asn Asp Met Lys Met Phe Tyr 
                85                  90                  95      


Lys Ser Val Leu Thr Ala Phe Phe Thr Ala Val Asp Ser Leu Arg Asn 
            100                 105                 110         


Lys Tyr Thr His Tyr Ser His Lys Asp Leu Asn Ile Arg Glu Ile Lys 
        115                 120                 125             


Ile Glu Cys Thr Leu Gly Gly Lys Asp Tyr Cys Ile Gly Leu Leu Asn 
    130                 135                 140                 


Ala Leu Asp Cys Ile Tyr Asp Ser Ala Val Asn Leu Leu Lys Leu Arg 
145                 150                 155                 160 


Phe Met Ala Asp Glu Asp Glu Val Ala His Leu Arg Arg Cys Lys Ala 
                165                 170                 175     


Val Asn Lys Lys Val Val Val Arg Thr Glu Lys Asp Gly Phe Tyr Tyr 
            180                 185                 190         


Arg Leu Ser Asp Asn Gly Glu Val Thr Glu Lys Gly Val Ile Phe Ile 
        195                 200                 205             


Ala Ser Met Phe Leu Asn Arg Lys Tyr Gly Phe Leu Phe Leu Lys Gln 
    210                 215                 220                 


Leu Glu Gly Phe Lys Arg Ser Asp Glu Lys Arg Tyr Arg Leu Thr Leu 
225                 230                 235                 240 


Glu Ala Phe Leu Ala Phe Ser Asn Ile Lys Pro Val Asp Arg Leu Lys 
                245                 250                 255     


Ser Asp Lys Leu Asp Arg Ala Ser Leu Gly Leu Asp Met Leu Asn Glu 
            260                 265                 270         


Leu Thr Lys Ile Pro Lys Glu Leu Ser Glu Thr Leu Ser Val Asp Cys 
        275                 280                 285             


Leu Tyr Lys Tyr Leu Ala Ser Asp Gly Glu Asp Asp Leu Arg Ser Arg 
    290                 295                 300                 


Ile Arg Tyr Gln Asp Arg Phe Val Pro Leu Ala Leu Glu Phe Ile Ser 
305                 310                 315                 320 


Gln Ser Asp Glu Phe Lys Asp Phe Arg Phe Tyr Thr Tyr Val Gly Asn 
                325                 330                 335     


Tyr Val Tyr Lys Gly Tyr Ile Lys Arg Leu Ile Asp Gly Thr Asp Lys 
            340                 345                 350         


Glu Arg Tyr Leu Ser Asp Arg Leu Cys Gly Phe Tyr Lys Ser Val Asn 
        355                 360                 365             


Asp Ala Ser Ser Asp Ala Ile Ala Gln Lys Tyr Gly Val Glu Ile Lys 
    370                 375                 380                 


Asp Ser Asn Glu Pro Asp Tyr Met Leu Pro Asp Ser Phe Arg Pro His 
385                 390                 395                 400 


Val Leu Arg Ala Thr Pro His Phe Val Ile Asn Asn Asn Asn Ile Gly 
                405                 410                 415     


Ile Lys Ile Cys Gly Asn Asp Cys Leu Pro Val Val Asn Gly Lys Gly 
            420                 425                 430         


Val Glu Ser Pro Glu Pro Asp Tyr Trp Leu Ser Ile Tyr Glu Leu Pro 
        435                 440                 445             


Ala Met Leu Phe Tyr Ala Tyr Leu Arg Glu Lys Asn Gly Lys Leu Leu 
    450                 455                 460                 


Lys Asp Tyr Lys Ser Ile Arg Glu Leu Ile Glu Asp Val Glu Lys Lys 
465                 470                 475                 480 


Ala Asp Glu Lys Asn Asp Arg Asp Lys Gly Ala Leu Met Ala Arg His 
                485                 490                 495     


Ile Asp Lys Glu Ile Ile Trp Thr Gln Thr Lys Leu Asp Glu Val Lys 
            500                 505                 510         


Arg Leu Glu Glu Lys Lys Val Ala Ala Tyr Gly Lys Lys Gly Arg Val 
        515                 520                 525             


Val Leu Lys Ser Gly Arg Met Ala Asp Leu Leu Ala His Asp Met Val 
    530                 535                 540                 


Arg Leu Gln Pro Ala Thr Lys Gly Ser Asp Lys Ile Thr Gly Ala Asn 
545                 550                 555                 560 


Phe Gln Ala Leu Gln Val Ser Leu Ala Tyr Phe Lys Arg Asp Ile Leu 
                565                 570                 575     


Ala Asp Val Phe Ser Arg Ala Met Leu Thr Thr Gly Asn His Arg His 
            580                 585                 590         


Pro Phe Leu Tyr Arg Ile Asp Val Ser His Cys Ser Ser Leu Arg Asp 
        595                 600                 605             


Phe Tyr Val Ala Tyr Leu Gly Glu Arg Arg Lys Tyr Phe Glu Asp Val 
    610                 615                 620                 


Ala Lys Lys Ile Thr Lys Asn Lys Leu Asn Thr Pro Cys His Ile Leu 
625                 630                 635                 640 


Arg Arg Leu Gln Arg Glu Gly Ser Gly Glu Glu Ala Gly Lys Asp Val 
                645                 650                 655     


Lys Pro Lys Phe Leu Pro Arg Gly Ile Phe Thr Gly Ser Ile Lys Ser 
            660                 665                 670         


Cys Leu Glu Lys Ser Ala Leu Asn Ile Asn Ile Arg Asn Ala Arg Asn 
        675                 680                 685             


Asp Val Lys Pro Ala Ile Asn Ala Ala Tyr Leu Ile Phe Met Tyr Tyr 
    690                 695                 700                 


Lys Glu Ile Glu Lys Gly Glu Phe Gln Gly Phe Tyr Gly Glu Lys Arg 
705                 710                 715                 720 


Arg Tyr Asp Ile Leu Glu Glu Gly Lys Pro Leu Asp Leu Asp Glu Arg 
                725                 730                 735     


Lys Lys Ala Leu Ala Ser Ile Lys Pro Ala Lys Ile Asp Val Ser Glu 
            740                 745                 750         


Ala Asn Met Pro Met Ser Lys Glu Glu His Leu Met Arg Lys Arg Tyr 
        755                 760                 765             


His Ala Val Cys Asn Asn Glu Ser Ala Ile Arg Met Tyr Gln Val Gln 
    770                 775                 780                 


Asp Ile Leu Leu Leu Leu Met Ala Lys Asp Ile Phe Lys Lys Ala Leu 
785                 790                 795                 800 


Ser Glu Val Val Met Ser Lys Lys Ile Gly Leu Glu Asn Leu Asn Gly 
                805                 810                 815     


Ile Phe Asp Ala Pro Val Asn Phe Val Lys Asn Phe Asp Asn Ile Lys 
            820                 825                 830         


Leu Thr Ala Thr Gly Ile Lys Ile Lys Asp Tyr Gly Lys Val Cys Arg 
        835                 840                 845             


Leu Gly Thr Asp Phe Lys Phe Asn Ser Leu Ile Lys Ala Phe His Lys 
    850                 855                 860                 


Val Tyr Ser Lys Ser Val Glu Met Asp Tyr Ser Asp Tyr Leu Lys Glu 
865                 870                 875                 880 


Glu Glu Glu Phe Glu Lys Tyr Arg Leu Asn Met Val Lys Leu Cys Arg 
                885                 890                 895     


Glu Val Glu Arg Gly Ile Thr Glu Asp Leu His Leu Ser Leu Asp Gly 
            900                 905                 910         


Lys Ser His Leu Ser Phe Asn Asp Asp Val Ile Lys Ser Tyr Asn Asp 
        915                 920                 925             


Lys Tyr Asn Val Phe Asn Gly Asp Asp Leu Thr Phe Phe Ile Asn Ala 
    930                 935                 940                 


Arg Asn Met Phe Met His Gly Asp Tyr Lys Tyr Glu Cys Val Lys Tyr 
945                 950                 955                 960 


Val Val Ser Glu His Phe Lys Gly Ser Leu Asn Asp Val Ser Phe Ala 
                965                 970                 975     


Lys Glu Thr Tyr Gly His Phe Cys Asn Leu Leu Glu Ser Met Arg Lys 
            980                 985                 990         


Lys Thr Gly Leu Arg Ile Asp Ile  
        995                 1000 


<210>  1754
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1754

Met Asn Thr His Gln Glu Glu Leu Gln Ser Trp Ile Thr Arg Lys Arg 
1               5                   10                  15      


Leu Pro Asp Thr Glu Met Lys Lys Tyr Trp Ala Ala Tyr Met Asn Leu 
            20                  25                  30          


Ala Arg Leu Asn Phe Phe Lys Thr Leu Met Phe Ile Ser Asn Ser Ile 
        35                  40                  45              


Gly Asp Leu Lys Pro Ala Lys Asp Asn Asn Gly Lys Gly Asn Thr Glu 
    50                  55                  60                  


Val Asn Met His Asn Met Gly Ile Leu Thr Ala Leu Leu Gly Pro Glu 
65                  70                  75                  80  


Asp Glu Glu Lys Ala Arg Leu Leu Ile Phe Lys His Phe Pro Phe Leu 
                85                  90                  95      


Arg Thr Phe Cys Ile Glu Lys Glu Leu Ser Leu Ser Lys Gln Arg Thr 
            100                 105                 110         


Ile Leu Ile Asp Met Ala Cys Ile Ile Gly Arg Tyr Arg Asn Met Tyr 
        115                 120                 125             


Ser His Ser Ile Phe Leu Ser Asp Asp Asn Glu Lys Val Leu Glu Ser 
    130                 135                 140                 


Glu Lys Arg Cys Ser Glu Tyr Leu Gln Ser Ile Leu Thr Val Ser Thr 
145                 150                 155                 160 


Arg Ile Ile Lys Glu Arg Tyr Arg Ser Asn Lys Asn Asp Ala Gln Arg 
                165                 170                 175     


Gly Met Ile Asp Asp Lys Ser Leu Glu Phe Ile Ser Glu Asn Lys Val 
            180                 185                 190         


Lys Phe Val Tyr Asp Glu Asn Gly Lys Arg Ile Thr Ala Pro Asn Lys 
        195                 200                 205             


Lys Tyr Tyr Leu Ser Thr Ile Asp Lys Asp Asn Thr His Leu Ser Tyr 
    210                 215                 220                 


Phe Gly Lys Leu Met Leu Thr Cys Ile Leu Leu Glu Lys Lys Tyr Ala 
225                 230                 235                 240 


Thr Ala Phe Leu Thr Gln Cys His Phe Leu Asp Ala Phe Asn Asp Ser 
                245                 250                 255     


Glu Val Ala Pro Lys Leu Ser Glu Arg Arg Leu Met Leu Glu Val Met 
            260                 265                 270         


Thr Ala Leu Arg Ile Arg Leu Ala Glu Lys Lys Leu Ser Asn Glu Lys 
        275                 280                 285             


Ser Glu Val Gln Ile Ser Leu Asp Ile Leu Asn Glu Leu Lys Lys Cys 
    290                 295                 300                 


Pro Phe Glu Leu Tyr Glu Leu Leu Gly Ser Glu Asp Lys Arg Leu Phe 
305                 310                 315                 320 


Thr Ile Val Ala Asp Thr Gly Glu Thr Val Leu Leu Arg Arg His Glu 
                325                 330                 335     


Asp Arg Phe Pro Gln Leu Ala Leu Ser Trp Ile Asp Ser Ser Lys Ala 
            340                 345                 350         


Phe Asp His Leu Arg Phe Gln Val Asn Ala Gly Lys Leu Arg Tyr Leu 
        355                 360                 365             


Phe Arg Asp Asn Lys His Cys Ile Asp Gly Gln Thr Arg Met Arg Val 
    370                 375                 380                 


Leu Glu Glu Pro Leu Asn Gly Tyr Arg Arg Leu Met Glu Phe Glu Glu 
385                 390                 395                 400 


Glu Arg Ile Gln Lys Gln Ser Gly Glu Ile Arg Ser Leu Trp Pro Gly 
                405                 410                 415     


Leu Asp Ile Leu Asn Lys Asp Glu Thr Pro Arg Asn Asp Ala Ser Val 
            420                 425                 430         


Leu Pro Tyr Ile Ser Asp Tyr Arg Val Arg Tyr Leu Phe Asp Gly Asp 
        435                 440                 445             


Asn Ile Gly Ile Ser Ile Gly Asp Phe Thr Pro Ser Ile Thr Lys Thr 
    450                 455                 460                 


Asp Glu Thr Lys Tyr Arg Val Thr Gly Lys Thr Ala Asp Cys Cys Leu 
465                 470                 475                 480 


Ser Lys Tyr Glu Leu Pro Gly Leu Leu Phe Tyr His Leu Leu Thr Leu 
                485                 490                 495     


Arg His Gly Asp Asn Lys Arg Ser Thr Lys Asn Ala Glu Asp Ile Ile 
            500                 505                 510         


Ile Asp Ala Ile Lys Arg Tyr Lys Arg Leu Phe Ser Asp Val Lys Glu 
        515                 520                 525             


Gly Ile Leu Lys Pro Ile Lys Glu Glu Asn Ala Asn Gln Leu Gly Asn 
    530                 535                 540                 


Arg Ile Trp Asn Ser Tyr Gly Ile Asp Ile Lys Asp Ile Pro Asp Lys 
545                 550                 555                 560 


Ile Ile Asp Tyr Leu Leu Val Arg Glu Cys Asn Glu Asp Glu Lys Tyr 
                565                 570                 575     


Thr Ala Trp Lys Asn Gly Phe Ile Ser Glu Met Leu Gln Ser Thr Lys 
            580                 585                 590         


Asn Arg Ile Lys Arg Phe Glu Lys Asp Ser Glu Ala Val Ile Ser Ser 
        595                 600                 605             


Asp Asn Lys Pro Gly Lys Lys Asn His Val Ser Leu Lys Pro Gly Ala 
    610                 615                 620                 


Tyr Ala Ser Phe Ile Ala Asn Asp Ile Val Phe Phe Gln Glu Cys Gly 
625                 630                 635                 640 


Ala Thr Glu Lys Met Thr Gly Leu Asn Phe Lys Val Met Gln Ser Arg 
                645                 650                 655     


Leu Ala Thr Phe Thr Lys Asp Gly Ser Thr Ser Phe Asn Ile Leu Leu 
            660                 665                 670         


Gln Thr Leu Lys Asn Ala His Leu Val Ser Thr Thr Tyr Gly Lys Gly 
        675                 680                 685             


Asp His Pro Phe Leu Tyr Arg Val Ile Lys Gln Gln Pro Ser Asp Ile 
    690                 695                 700                 


Val Gln Phe Tyr Lys Ile Tyr Leu Asn Glu Lys Val Leu Tyr Leu Gln 
705                 710                 715                 720 


Ser Asp Ile Pro Asp Asn Ala Ile Phe Leu His Gly Glu Arg Lys Arg 
                725                 730                 735     


Trp Glu Asn Arg Asn Glu Gln Tyr Tyr Arg Asp Leu Ala Glu Arg Tyr 
            740                 745                 750         


Leu Gln Arg Pro Ile Gln Leu Pro Arg Gln Leu Phe Glu Ser His Ile 
        755                 760                 765             


Arg Gln Leu Leu Leu Ser Asp Cys Ile Lys Gly Glu Arg Gly Asn Asp 
    770                 775                 780                 


Leu Lys Glu Ala Ile Asn Ser Ala Ala Ser Gln Gly Arg Cys Asn Thr 
785                 790                 795                 800 


Thr Tyr Met Ile Met Glu Tyr Phe Ala Asp Tyr Leu Cys Asp Gly Thr 
                805                 810                 815     


Gln Phe Phe Tyr Gly Leu Phe Asp Gly Asp Leu Ser His Glu Tyr Asn 
            820                 825                 830         


Tyr Arg Phe Tyr Ser Leu Ile Ser Asn Asn Ile Glu Asn Ser Lys Lys 
        835                 840                 845             


Leu Val Leu Thr Leu Lys Lys Gly Asn Asn Ser Lys Glu Ser Pro Phe 
    850                 855                 860                 


Ile Ser Ala Leu Glu Arg Gly Ile His Trp Ser Lys Met Asn Pro Leu 
865                 870                 875                 880 


Met Lys Lys Gly Leu Lys Asn Asp Ser Ser Glu Gly Asp Phe Val His 
                885                 890                 895     


Ala Ala Lys Arg Ala Tyr Lys Glu Met Thr Glu Thr Glu Arg Met Phe 
            900                 905                 910         


Arg Arg Tyr Ala Val Gln Asp Glu Val Leu Phe Leu Ala Ala Lys Ile 
        915                 920                 925             


Thr Ile Arg Arg Ala Leu Gly Leu Ser Glu Gln Tyr Asn Cys Leu Leu 
    930                 935                 940                 


Gly Asp Ile Lys Pro Gln Gly Gly Ser Leu Leu Glu Gln Thr Ile Pro 
945                 950                 955                 960 


Ser Ile Thr Thr Lys His Thr Ile Asn Thr Gly Asn Lys Lys Gln Lys 
                965                 970                 975     


Pro Lys Gln Val Gln Ile Leu Gln Lys Asn Val Lys Leu Lys Asp Phe 
            980                 985                 990         


Gly Lys Val Phe Lys Leu Leu Asn  Asp Arg Arg Ile Phe  Asp Leu Leu 
        995                 1000                 1005             


Phe Asn  Lys Gly Asn Glu Ala  Val Ser Met Thr Asp  Leu Cys Glu 
    1010                 1015                 1020             


Glu Leu  Glu Arg Tyr Asp Arg  His Arg Val Asp Val  Phe Asp Ser 
    1025                 1030                 1035             


Val Leu  Lys Tyr Glu Ser Lys  Ile Thr Lys Gly Tyr  Thr Asn Lys 
    1040                 1045                 1050             


Glu Leu  Met Asn Glu Ser Gly  Gln Ile Asp Phe Lys  Ala Ile Gln 
    1055                 1060                 1065             


Ala Phe  Asp Lys Gln Asn Thr  Thr Ala Asp Lys Glu  Asp Leu Arg 
    1070                 1075                 1080             


Leu Ile  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Gln Tyr Asn 
    1085                 1090                 1095             


Asn Glu  Pro Ile Leu Phe Asp  Lys Asp Ile Pro Glu  Ile Ala Asp 
    1100                 1105                 1110             


Glu Ile  Ser Ile Ile Ala Lys  Asp Ile Glu Glu Asn  Thr Lys 
    1115                 1120                 1125         


<210>  1755
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1755

Met Asn Thr His Gln Glu Glu Leu Gln Ser Trp Ile Thr Arg Lys Arg 
1               5                   10                  15      


Leu Pro Asp Thr Glu Met Lys Lys Tyr Trp Ala Ala Tyr Met Asn Leu 
            20                  25                  30          


Ala Arg Leu Asn Phe Phe Lys Thr Leu Met Phe Ile Ser Asn Ser Ile 
        35                  40                  45              


Gly Asp Leu Lys Pro Ala Lys Asp Asn Asn Gly Lys Gly Asn Thr Glu 
    50                  55                  60                  


Val Asn Met His Asn Met Gly Ile Leu Thr Ala Leu Leu Gly Pro Glu 
65                  70                  75                  80  


Asp Glu Glu Lys Ala Arg Leu Leu Ile Phe Lys His Phe Pro Phe Leu 
                85                  90                  95      


Arg Thr Phe Cys Ile Glu Lys Glu Leu Ser Leu Ser Lys Gln Arg Thr 
            100                 105                 110         


Ile Leu Ile Asp Met Ala Cys Ile Ile Gly Arg Tyr Arg Asn Met Tyr 
        115                 120                 125             


Ser His Ser Ile Phe Leu Ser Asp Asp Asn Glu Lys Val Leu Glu Ser 
    130                 135                 140                 


Glu Lys Arg Cys Ser Glu Tyr Leu Gln Ser Ile Leu Thr Val Ser Thr 
145                 150                 155                 160 


Arg Ile Ile Lys Glu Arg Tyr Arg Ser Asn Lys Asn Asp Ala Gln Arg 
                165                 170                 175     


Gly Met Ile Asp Asp Lys Ser Leu Glu Phe Ile Ser Glu Asn Lys Val 
            180                 185                 190         


Lys Phe Val Tyr Asp Glu Asn Gly Lys Arg Ile Thr Ala Pro Asn Lys 
        195                 200                 205             


Lys Tyr Tyr Leu Ser Thr Ile Asp Lys Asp Asn Thr His Leu Ser Tyr 
    210                 215                 220                 


Phe Gly Lys Leu Met Leu Thr Cys Ile Leu Leu Glu Lys Lys Tyr Ala 
225                 230                 235                 240 


Thr Ala Phe Leu Thr Gln Cys His Phe Leu Asp Ala Phe Asn Asp Ser 
                245                 250                 255     


Glu Ala Ala Pro Lys Leu Ser Glu Arg Arg Leu Met Leu Glu Val Met 
            260                 265                 270         


Thr Ala Leu Arg Ile Arg Leu Ala Glu Lys Lys Leu Ser Asn Glu Lys 
        275                 280                 285             


Ser Glu Val Gln Ile Ser Leu Asp Ile Leu Asn Glu Leu Lys Lys Cys 
    290                 295                 300                 


Pro Phe Glu Leu Tyr Glu Leu Leu Gly Ser Glu Asp Lys Arg Leu Phe 
305                 310                 315                 320 


Thr Ile Val Ala Asp Thr Gly Glu Thr Ile Leu Leu Arg Arg His Glu 
                325                 330                 335     


Asp Arg Phe Pro Gln Leu Ala Leu Ser Trp Ile Asp Ser Ser Lys Ala 
            340                 345                 350         


Phe Asp His Leu Arg Phe Gln Val Asn Ala Gly Lys Leu Arg Tyr Leu 
        355                 360                 365             


Phe Arg Asp Asn Lys His Cys Ile Asp Gly Gln Thr Arg Met Arg Val 
    370                 375                 380                 


Leu Glu Glu Pro Leu Asn Gly Tyr Arg Arg Leu Met Glu Phe Glu Glu 
385                 390                 395                 400 


Glu Trp Ile Gln Lys Gln Ser Gly Glu Ile Arg Ser Leu Trp Pro Gly 
                405                 410                 415     


Leu Asp Ile Leu Asn Lys Asp Glu Thr Pro Arg Asn Asp Ala Ser Val 
            420                 425                 430         


Leu Pro Tyr Ile Ser Asp Tyr Arg Val Arg Tyr Leu Phe Asp Gly Asp 
        435                 440                 445             


Asn Ile Gly Ile Ser Ile Gly Asp Phe Thr Pro Ser Ile Thr Lys Thr 
    450                 455                 460                 


Asp Glu Thr Lys Tyr Arg Val Thr Gly Lys Thr Ala Asp Cys Cys Leu 
465                 470                 475                 480 


Ser Lys Tyr Glu Leu Pro Gly Leu Leu Phe Tyr His Leu Leu Thr Leu 
                485                 490                 495     


Arg Tyr Gly Asp Asn Lys Arg Ser Thr Lys Asn Ala Glu Asp Ile Ile 
            500                 505                 510         


Ile Asp Ala Ile Lys Arg Tyr Lys Arg Leu Phe Ser Asp Val Lys Glu 
        515                 520                 525             


Gly Ile Leu Lys Pro Ile Lys Glu Gly Asn Ala Asn Gln Leu Gly Asn 
    530                 535                 540                 


Arg Ile Trp Asn Ser Tyr Gly Ile Asp Ile Lys Asp Ile Pro Asp Lys 
545                 550                 555                 560 


Ile Ile Asp Tyr Leu Leu Val Arg Glu Cys Asn Glu Asp Glu Lys Phe 
                565                 570                 575     


Thr Ala Trp Lys Asn Gly Leu Ile Ser Glu Met Leu Gln Ser Thr Lys 
            580                 585                 590         


Asn Arg Ile Lys Arg Phe Glu Lys Asp Ser Glu Ala Val Ile Ser Ser 
        595                 600                 605             


Asp Asn Lys Pro Gly Lys Lys Asn His Val Ser Leu Lys Pro Gly Ala 
    610                 615                 620                 


Tyr Ala Ser Phe Ile Ala Asn Asp Ile Val Phe Phe Gln Glu Cys Gly 
625                 630                 635                 640 


Ala Thr Glu Lys Met Thr Gly Leu Asn Phe Lys Val Met Gln Ser Arg 
                645                 650                 655     


Leu Ala Thr Phe Thr Lys Asp Gly Ser Thr Ser Phe Asn Ile Leu Leu 
            660                 665                 670         


Gln Thr Leu Lys Asn Ala His Leu Val Ser Asn Thr Tyr Gly Lys Gly 
        675                 680                 685             


Asp His Pro Phe Leu Tyr Arg Val Ile Lys Gln Gln Pro Ser Asp Ile 
    690                 695                 700                 


Val Gln Phe Tyr Lys Ile Tyr Leu Asn Glu Lys Val Leu Tyr Leu Gln 
705                 710                 715                 720 


Ser Asp Ile Pro Asp Asn Ala Ile Phe Leu His Gly Glu Arg Lys Arg 
                725                 730                 735     


Trp Glu Asn Arg Asn Glu Gln Tyr Tyr Arg Asp Leu Ala Glu Arg Tyr 
            740                 745                 750         


Leu Gln Arg Pro Ile Gln Leu Pro Arg Gln Leu Phe Glu Ser His Ile 
        755                 760                 765             


Arg Gln Leu Leu Leu Ser Asp Cys Ile Lys Gly Glu Arg Gly Asn Asp 
    770                 775                 780                 


Leu Lys Glu Ala Ile Asn Ser Ala Ala Ser Gln Gly Arg Cys Asn Thr 
785                 790                 795                 800 


Thr Tyr Met Ile Met Glu Tyr Phe Ala Asp Tyr Leu Cys Asp Gly Thr 
                805                 810                 815     


Gln Phe Phe Tyr Gly Leu Phe Asp Gly Asp Leu Ser His Glu Tyr Asn 
            820                 825                 830         


Tyr Arg Phe Tyr Ser Leu Ile Ser Asn Asn Ile Glu Asn Ser Lys Lys 
        835                 840                 845             


Leu Val Leu Thr Leu Lys Lys Gly Asn Asn Ser Lys Glu Ser Pro Phe 
    850                 855                 860                 


Ile Ser Ala Leu Glu Arg Gly Ile His Trp Ser Lys Arg Asn Pro Leu 
865                 870                 875                 880 


Met Lys Lys Gly Leu Lys Asn Asp Ser Ser Glu Gly Asp Phe Val His 
                885                 890                 895     


Ala Ala Lys Arg Ala Tyr Lys Glu Met Thr Glu Thr Glu Arg Met Phe 
            900                 905                 910         


Arg Arg Tyr Ala Val Gln Asp Glu Val Leu Phe Leu Ala Ala Lys Ile 
        915                 920                 925             


Thr Ile Arg Arg Ala Leu Gly Leu Ser Glu Gln Tyr Asn Cys Leu Leu 
    930                 935                 940                 


Gly Asp Ile Lys Pro Gln Gly Gly Ser Leu Leu Glu Gln Thr Ile Pro 
945                 950                 955                 960 


Ser Ile Thr Thr Lys His Thr Ile Asn Thr Gly Asn Lys Lys Gln Lys 
                965                 970                 975     


Pro Lys Gln Val Gln Ile Leu Gln Lys Asn Val Lys Leu Lys Asp Phe 
            980                 985                 990         


Gly Lys Val Phe Lys Leu Leu Asn  Asp Arg Arg Ile Phe  Asp Leu Leu 
        995                 1000                 1005             


Phe Asn  Lys Gly Asn Glu Ala  Val Ser Met Thr Asp  Leu Cys Glu 
    1010                 1015                 1020             


Glu Leu  Glu Arg Tyr Asp Arg  His Arg Val Asp Val  Phe Asp Ser 
    1025                 1030                 1035             


Val Leu  Lys Tyr Glu Ser Lys  Ile Thr Lys Gly Tyr  Thr Asn Lys 
    1040                 1045                 1050             


Glu Leu  Met Asn Glu Ser Gly  Gln Ile Asp Phe Lys  Ala Ile Gln 
    1055                 1060                 1065             


Ala Phe  Asp Lys Gln Asn Thr  Thr Ala Asp Lys Glu  Asp Leu Arg 
    1070                 1075                 1080             


Leu Ile  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Gln Tyr Asn 
    1085                 1090                 1095             


Asn Glu  Pro Ile Leu Phe Asp  Lys Asp Ile Pro Glu  Ile Ala Asp 
    1100                 1105                 1110             


Glu Ile  Ser Ile Ile Ala Lys  Asp Ile Glu Glu Asn  Thr Lys 
    1115                 1120                 1125         


<210>  1756
<211>  1126
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1756

Met Glu Thr Asn Gln Lys Pro Asn Tyr Lys Lys Phe Thr Asn Glu Gln 
1               5                   10                  15      


Asp Lys Pro Phe Phe Ser Gly Tyr Leu Asn Thr Ala Lys Gln Asn Val 
            20                  25                  30          


Phe Ile Ile Phe Arg Asp Ile Ser Glu Arg Leu Gly Leu Gly Phe Asp 
        35                  40                  45              


Leu Ser Asn Asp Asp Asn Ile Met Asn Ala Asp Leu Trp Glu Tyr Leu 
    50                  55                  60                  


Lys Asn Asn Lys Arg Pro Glu Ile Thr Gln His Ile Ile Glu Lys Leu 
65                  70                  75                  80  


Met Tyr His Phe Pro Phe Ala Ser His Leu Thr Thr Asn Tyr Ala Tyr 
                85                  90                  95      


Tyr Lys Arg Lys Glu Asn Gln Ala Glu Pro Leu Asp Tyr Tyr Glu Ile 
            100                 105                 110         


Phe Glu Leu Leu Ile Lys Gln Leu Tyr Glu Tyr Arg Asn Phe Tyr Thr 
        115                 120                 125             


His Val Val His Asp Pro Val Ile Met Asn Lys Val Ile Ile Asn Gly 
    130                 135                 140                 


Met Arg Ile Leu Phe Asp Ala Ala Arg Ile Glu Val Lys Asp Arg Phe 
145                 150                 155                 160 


Asn Leu Lys Thr Glu Asp Val Asn His Leu Val Arg Leu Gly Pro Lys 
                165                 170                 175     


Gly Lys Glu Asn Lys Asn Phe Tyr Tyr Asn Phe Ser Asp Asp Glu Arg 
            180                 185                 190         


Asn Val Ser Glu Lys Gly Leu Ala Phe Phe Ile Cys Leu Gly Leu Gln 
        195                 200                 205             


Arg Lys Asp Ala Gln Ile Phe Leu Lys Ser Leu Val Gly Phe Lys Leu 
    210                 215                 220                 


Ser Glu Ser Pro Ser Gln Lys Ala Thr Leu Glu Val Tyr Thr Asn Tyr 
225                 230                 235                 240 


Ser Pro Arg Ile Pro Gln Pro Arg Leu Thr Ser Asp Asn Ser Ile Glu 
                245                 250                 255     


Gly Leu Leu Leu Asp Met Val Asn Glu Leu Lys Arg Cys Pro Lys Glu 
            260                 265                 270         


Leu Tyr His Leu Leu Ser Ile Glu Asp Arg Glu Lys Phe Lys Ala Val 
        275                 280                 285             


Lys Glu Asp Asn Thr Tyr Asp Asp Asn Asp Glu Tyr Glu Ala Met Pro 
    290                 295                 300                 


Val Leu Lys Arg Ser Arg Asn Arg Phe Phe Tyr Phe Ala Leu Arg Tyr 
305                 310                 315                 320 


Leu Asp Asn Asn Leu Gln Asn Ile Lys Phe His Ile Asp Leu Gly Asn 
                325                 330                 335     


Tyr Cys Phe His Val Tyr Glu Gln Glu Ile Glu Glu Ile Val Arg Lys 
            340                 345                 350         


Arg Arg Trp Ile Lys Arg Met Thr Ser Phe Gly Asn Leu Glu Asp Phe 
        355                 360                 365             


Ala Asp Lys Met Arg Pro Ala Tyr Trp Val Glu Lys Thr Leu Lys Leu 
    370                 375                 380                 


Glu Asp Lys Lys Val Asp Asn Pro Asn Ile Tyr Ile Thr Asp Thr Thr 
385                 390                 395                 400 


Pro His Tyr His Ile Asn Gly Gln Asn Ile Gly Ile Lys Phe Ile Asn 
                405                 410                 415     


Asn Tyr Val Ala Leu Arg Lys Asn Asn Lys Ile Trp Pro Glu Leu Pro 
            420                 425                 430         


Asp Phe Gly Asp Asn Asn Lys Thr Asn Lys Pro Arg Asn Glu Thr Pro 
        435                 440                 445             


Asp Cys Trp Leu Ser Leu Tyr Glu Leu Pro Ser Ile Val Phe Tyr His 
    450                 455                 460                 


Leu Leu Lys Gln Gln Asn Ile Gly Leu Pro Ser Val Glu Arg Ile Ile 
465                 470                 475                 480 


Asn Asp His Arg Asn Gln Ile Arg Gly Phe Phe Asn Asp Leu Glu Asn 
                485                 490                 495     


Asn Arg Ile Val Pro Ser Phe Thr Asp Thr Thr Leu Lys Ala Glu Leu 
            500                 505                 510         


Lys Asn Arg Gly Leu Lys Lys Ser Gln Ile Pro Ser Ala Ile Val Lys 
        515                 520                 525             


Tyr Leu Thr Ser Lys Pro Val Met Ser Phe Glu Ala Lys Ala Ser Lys 
    530                 535                 540                 


Arg Leu Ser Glu Leu Val Thr Glu Thr Ser Glu Lys Leu Asp Lys Ile 
545                 550                 555                 560 


Lys Arg Gln Glu Gln His Tyr Leu Lys Lys Pro Gly Ser Lys Asp Tyr 
                565                 570                 575     


Ile Asp Met Lys Cys Gly His Leu Ala Asp Phe Leu Ala Arg Asp Met 
            580                 585                 590         


Ile Ser Leu Gln Lys Pro Tyr Asn Asn Met Asp Gly Lys Ala Asn Ser 
        595                 600                 605             


Thr Glu Phe Gln Ile Leu Gln Ser Lys Leu Ala Tyr Phe Gly Lys Asn 
    610                 615                 620                 


Lys Asp Ser Leu Ser Lys Thr Phe His Leu Phe Asn Leu Met Gly Ser 
625                 630                 635                 640 


Gln Asn Ile His Pro Phe Leu Tyr Lys Ile Asp Ile Asn Gln Cys Ile 
                645                 650                 655     


Gly Ile Leu Asp Phe Tyr Lys Lys Tyr Leu Asp His Arg Tyr Ile Tyr 
            660                 665                 670         


Phe Lys Gln Cys Leu Asn Glu Lys Arg Tyr Ser Glu Tyr His Phe Leu 
        675                 680                 685             


Lys Leu Gly Gly Lys Ser Lys Glu Gln Gly Arg Asp Tyr Phe Val Lys 
    690                 695                 700                 


Leu Ala Asn Thr Leu Gln Lys Glu Thr Val Met Asn Leu Pro Arg Gly 
705                 710                 715                 720 


Leu Phe Leu Glu Ser Ile Ile Arg Ile Leu Lys Ala Asn Asp Asn Ser 
                725                 730                 735     


Arg Pro Phe Ala Ile Glu Ile Glu Lys Met Glu Arg Val Asn Ala Ala 
            740                 745                 750         


Tyr Val Ile Asp Gln Tyr Leu Gly Arg Ile Leu Asn Asp Lys Pro Gln 
        755                 760                 765             


Val Phe Tyr Ser Tyr Asn Lys Ser Tyr Glu Phe Leu Asn Lys Leu Phe 
    770                 775                 780                 


Asp Ser Arg Lys Ile Ser Glu Lys Arg Asn Ala Leu Pro Glu Val Tyr 
785                 790                 795                 800 


Phe Asp Thr Gly Glu Leu Ala Lys Lys Thr Thr Ile Ser Val Lys Gly 
                805                 810                 815     


Gln Lys Asp Asn Glu Ile Thr Arg Ser Leu Thr Lys Thr Val Glu Gln 
            820                 825                 830         


His Ile Lys Arg Asn Arg Ile Phe Asp Glu Lys Glu Lys Thr Lys Val 
        835                 840                 845             


Tyr Asp Gln Tyr Met Ala Arg Tyr Asn Asp Phe Thr Glu Asn Glu Lys 
    850                 855                 860                 


Gln Ile Arg Leu Ala Lys Thr Cys Asp Glu Val Met Phe Met Met Ile 
865                 870                 875                 880 


Asp Asp Ile Phe Arg Lys Tyr Phe Val Leu Asp Asn Gly Thr Leu Lys 
                885                 890                 895     


Lys Lys Thr Ile Glu Ala Ile Pro Phe Ile Gln Leu Gly Asp Asp Tyr 
            900                 905                 910         


Lys Leu Gly Ser Ile Lys Pro Asp Ser Glu Lys Gly Phe Leu Ser Leu 
        915                 920                 925             


Gln Thr Thr Val Lys Leu Gln Met Pro Phe Thr Tyr Glu Thr Asn Thr 
    930                 935                 940                 


Asp Lys Val Leu Lys Val Lys Gly Ala Glu Ser Lys Leu Ser Ala Arg 
945                 950                 955                 960 


Tyr Ile Lys Thr Ile Val Arg Glu Thr Ile Lys Ile Lys Asn Tyr Gly 
                965                 970                 975     


Asp Phe Arg Ala Phe Leu Lys Asp Arg Arg Ile Ser Ser Leu Leu Pro 
            980                 985                 990         


Tyr Leu Ser Asp Arg Glu Ile His  Tyr Glu Ala Leu Gln  Lys Glu Leu 
        995                 1000                 1005             


Glu Leu  Phe Gln Lys Ala Arg  Met Glu Val Phe Asp  Arg Ile Phe 
    1010                 1015                 1020             


Arg Phe  Glu Lys Asp Ile Thr  Gly Ala Phe His Ile  Pro Lys Asn 
    1025                 1030                 1035             


Lys Asn  Gly Tyr Ile Tyr His  Thr Glu Ile Leu Lys  Gln Lys Ile 
    1040                 1045                 1050             


Asn Glu  Gly Asp Glu Arg Phe  Gly Phe Ile Lys Glu  Leu Arg Asn 
    1055                 1060                 1065             


Ala Phe  Asn His Ser Asn Tyr  Pro Ala Tyr Val Leu  Phe Lys Asp 
    1070                 1075                 1080             


Phe Ile  Asp Gly Ser Gln Phe  Asn Glu Leu Arg Asn  Tyr Lys Ser 
    1085                 1090                 1095             


Gly Asp  Thr Glu Val Glu Asn  Lys Ser Val Ile Leu  Gln Phe Lys 
    1100                 1105                 1110             


Asn Leu  Leu Ile Gln Tyr Tyr  Asp Glu Leu Thr Asp  Leu 
    1115                 1120                 1125     


<210>  1757
<211>  1188
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (685)..(791)
<223>  Xaa can be any naturally occurring amino acid

<400>  1757

Met Pro Asn Pro Val Ile Glu Pro Glu Ser Ala Gln Ala Met Lys Ser 
1               5                   10                  15      


Ala Arg Ala Ala Phe Ala Asn Leu Ala Arg Met Asn Leu Phe Ser Thr 
            20                  25                  30          


Leu Ser Phe Ile Ser Asp Ala Val Gly Ile Gln Asp Ser Asp Lys Phe 
        35                  40                  45              


Glu Glu His Ile Leu Asn Met Lys Ile Leu Asp Leu Asp Asn Thr Leu 
    50                  55                  60                  


Gln Gln Ala Ala Asp Arg Gln Lys Ala Phe Arg Leu Met Cys Arg His 
65                  70                  75                  80  


Phe Gly Phe Ile Arg Tyr Met Asn Glu Glu Asp Glu Lys Arg Lys Lys 
                85                  90                  95      


Asp Lys Asp Glu Asp Tyr Ile Lys Thr Leu Gly Tyr Asp Lys Phe Val 
            100                 105                 110         


Asp Ile Leu Lys Arg Ala Ile Thr Val Leu Ile Tyr Tyr Arg Asp Gln 
        115                 120                 125             


Ser Thr His His Val Phe Arg Asp Lys Arg Asn Thr Asp Arg Ser Tyr 
    130                 135                 140                 


Leu Glu Ala Glu Ala Leu Leu Ala Trp Glu Leu Asp Thr Cys Phe Thr 
145                 150                 155                 160 


Ile Ala Ile Arg Val Ile Lys Glu Arg Phe Lys Lys Asp Phe Ser Asn 
                165                 170                 175     


Glu Arg Thr Lys His Cys Leu Asp Phe Leu Asn Gly Arg Thr Arg Lys 
            180                 185                 190         


Asp Asn Ser Gly Lys Thr Val Leu Asn Asn Gly His Phe Phe Ala Leu 
        195                 200                 205             


Ala Arg Lys Asp Gly Glu Gly His Leu Arg Leu Thr Glu Phe Gly Lys 
    210                 215                 220                 


Val Tyr Leu Leu Ser Leu Phe Leu Ser Lys Gln Tyr Ala Ser Glu Leu 
225                 230                 235                 240 


Leu Asp Lys Trp Tyr Ser Gln Glu Leu Gly Asn Gly Ala Trp Arg Asp 
                245                 250                 255     


Pro Ala Pro Ala Asp Ser Pro Gln Arg Ser Tyr Leu Arg Asp Ile Leu 
            260                 265                 270         


Ser Ala Leu Arg Ile Arg Leu Pro His Asp Arg Ile Asp Ser Thr Val 
        275                 280                 285             


Gly Ile Asn Gln Ile Gly Met Asp Met Leu Gly Glu Leu Lys Arg Cys 
    290                 295                 300                 


Pro Lys Glu Leu Phe Pro Ile Leu Ala Ala Asn Asp Gln Lys Leu Phe 
305                 310                 315                 320 


Glu Ala Ile Asp Ser Ser Thr Gly Asp Lys Val Leu Met Arg Arg Ser 
                325                 330                 335     


Ser Asp Arg Phe Pro His Leu Ala Leu Ser Tyr Ile Asp Tyr Thr Gly 
            340                 345                 350         


Leu Phe Lys Ser Ala Arg Phe Ala Ile Asn Val Gly Gln Tyr Arg Tyr 
        355                 360                 365             


Val Phe Lys Asp Lys Lys Leu Cys Ile Asp Gly Ser Thr Glu Pro Arg 
    370                 375                 380                 


Ile Leu Gln Lys Asp Leu Asn Gly Phe Gly Arg Ile Gln Glu Ile Glu 
385                 390                 395                 400 


Ala Ile Arg Thr Leu Glu Pro Gln Ala Pro Asp Asn Pro Trp Pro Tyr 
                405                 410                 415     


Gln Ser Leu Ile Lys Gly Phe Glu Glu Thr Pro Arg Lys Asp Ala Glu 
            420                 425                 430         


Cys Cys Pro Tyr Ile Arg Asp Thr Arg Thr His Tyr Leu Phe Asn Arg 
        435                 440                 445             


Asp Arg Ile Gly Val Cys Phe Gly Pro Lys Pro Asp Ala Phe Pro Thr 
    450                 455                 460                 


Pro Tyr Asp Ser Ser Leu Thr Lys Ser Glu Asp Lys Ile Trp Tyr Leu 
465                 470                 475                 480 


Pro Ala Ile Thr Pro Ser Pro Gly Gln Gly Gly His Ala Lys Val Ser 
                485                 490                 495     


Cys Val Glu Pro His Cys Trp Leu Ser Ile Tyr Asp Ile Pro Ala Met 
            500                 505                 510         


Thr Phe Leu Ala Phe Leu Thr Lys Asp Arg Ile Ser Gln Gly Leu Gln 
        515                 520                 525             


Tyr Val Glu His Ile Met Leu Glu Cys Val Leu Arg Tyr Arg Ala Leu 
    530                 535                 540                 


Phe Lys Asp Ile Ala Asp Gly Ser Val Phe Asp Gly Ala Gln Gln Asp 
545                 550                 555                 560 


Ile Glu Ala His Ile Arg Thr Lys Tyr Gly Ile Ala Phe Lys Asp Ile 
                565                 570                 575     


Pro Lys Ser Leu Gln His Phe Leu Lys Lys Glu Gly Tyr Asp Ala Asp 
            580                 585                 590         


Ala Arg Phe Arg Glu His Leu Ile Arg Val Ile Glu Gly Asp Ala Lys 
        595                 600                 605             


Ser Gly Val Lys Gly Leu Ile Glu Arg Thr Asp Asn Arg Ile Ala Ser 
    610                 615                 620                 


Trp Glu Arg Asp Leu Gln Ser Val Arg Ser Val Lys Glu Asn Lys Ala 
625                 630                 635                 640 


Gly Lys Glu Gly Phe Val Glu Ile Lys Thr Gly Thr Leu Met Ser Trp 
                645                 650                 655     


Leu Leu Lys Asp Ile Val Tyr Ile Gln Lys Tyr Leu Pro Val Thr Asp 
            660                 665                 670         


Pro Val Thr Gly Leu Thr Arg Ser Asn Lys Leu Thr Xaa Xaa Xaa Xaa 
        675                 680                 685             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    690                 695                 700                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
705                 710                 715                 720 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                725                 730                 735     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            740                 745                 750         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        755                 760                 765             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    770                 775                 780                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Met Ile Asp Asn Tyr Gly Phe Val Lys 
785                 790                 795                 800 


Ala Glu Arg Arg Lys Trp Gln Arg Asp Tyr Leu Lys Thr Leu Pro Lys 
                805                 810                 815     


Glu Phe Tyr Asn Ser Glu Thr Gly Arg Phe Cys Pro Ile Phe Leu Pro 
            820                 825                 830         


Ser Gly Leu Phe Glu Lys Pro Leu Arg Glu Gln Leu Asp Arg Ile Pro 
        835                 840                 845             


Glu Leu Arg Ala Ala Leu Ser Glu Gly Asp Lys Asp Gly Arg Lys Ala 
    850                 855                 860                 


Asn Thr Thr Tyr Met Ile Lys Lys Tyr Phe Glu Ile Val Arg Gly Asp 
865                 870                 875                 880 


Gly His Gln Arg Tyr Tyr Asp Phe Met Arg Thr Tyr Pro Phe His Glu 
                885                 890                 895     


Tyr Ile Asp Lys Lys Arg Lys Asp Ile Lys Val Gln Asn Ile Arg Thr 
            900                 905                 910         


Thr Asn Leu Ser Thr Gly Ile Val Ser Asp Asp Ser Asn Phe Arg Arg 
        915                 920                 925             


Ala Val Lys Glu Val Leu Ser Ser Arg Pro Ala Ala Gln Ser Asp Thr 
    930                 935                 940                 


Arg Gln Asn His Thr Arg Pro Gly His Thr Gln Pro Thr Pro Tyr Ser 
945                 950                 955                 960 


Val Asp Thr Leu Lys Lys Lys Trp Lys Glu Met Ser Glu Thr Glu Arg 
                965                 970                 975     


Thr Leu Arg Arg Tyr Glu Val Gln Asp Met Leu Leu Phe Met Leu Gly 
            980                 985                 990         


Thr Ser Ile Val Leu His Thr Asp  Thr Gly Ala Arg Leu  Ala Glu Thr 
        995                 1000                 1005             


Gly Leu  Leu Leu Lys Asn Val  Met Gly Gly Asn Glu  Gly Thr Asp 
    1010                 1015                 1020             


Ile Leu  Ser Gln Pro Val Asn  Ile Thr Thr Ser Val  Lys Ile Arg 
    1025                 1030                 1035             


Gln Lys  Ile Tyr Lys Ile Gln  Gln Thr Glu Val Lys  Ile Arg Asp 
    1040                 1045                 1050             


Tyr Thr  Lys Ile Phe Ala Leu  Leu Arg Asp Thr Arg  Thr Arg Ser 
    1055                 1060                 1065             


Leu Leu  Pro Val Leu Pro Ile  Glu Glu Val Asp Ala  Ala Glu Leu 
    1070                 1075                 1080             


Gln Asp  Glu Leu Asn Arg Tyr  Asp Ile Glu Arg Pro  Lys Val Phe 
    1085                 1090                 1095             


Arg Asp  Leu Leu Ile Phe Glu  Lys Thr Gln Tyr Asp  Ser Tyr His 
    1100                 1105                 1110             


Ser Tyr  Leu Ser Glu Gly Arg  Ile Asp Phe Arg Arg  Leu Leu Glu 
    1115                 1120                 1125             


Leu Asp  Ser Thr Leu Pro Glu  Glu Lys Lys Glu Ile  Leu Arg Leu 
    1130                 1135                 1140             


Ile Arg  Asn Ala Phe Ser His  Asn Thr Tyr Ala Asn  Pro Gln Lys 
    1145                 1150                 1155             


Ala Gln  Tyr Glu Ala Arg Leu  Arg Pro Gln Pro Glu  Leu Gly Pro 
    1160                 1165                 1170             


Ala Glu  Ser Met Glu Gln Asn  Val Lys Glu Ile Val  Asn Arg Gln 
    1175                 1180                 1185             


<210>  1758
<211>  1383
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1758

Met Gly Lys Asp His Lys Lys Gly Asn Gly Ala Pro Gln Asn Gln Asn 
1               5                   10                  15      


Thr Gly Lys Gln Gln Lys Ser Gly Lys Val Gln Lys Pro Gln Ala Leu 
            20                  25                  30          


Val Val Asn Glu Thr Asn Lys Tyr Val Leu Gly Gly Tyr Phe Ser Leu 
        35                  40                  45              


Gly Leu Thr Asn Phe Tyr Lys Thr Val Leu Leu Val Phe Asn Lys Ala 
    50                  55                  60                  


Gly Ile Lys Val Val Ser Glu Asn Gly Asn Ile Ile Tyr Ser Asp Glu 
65                  70                  75                  80  


Lys Ile Gly Gln Val Leu Asn Thr Leu Tyr Lys Ser Thr Leu Asn Pro 
                85                  90                  95      


Arg Pro Ser Phe Glu Pro Phe Glu Glu Ala Trp Thr Lys His Phe Lys 
            100                 105                 110         


Leu Asn Thr Asn Gln Gln Val Lys Leu Gln Lys Leu Leu Phe His His 
        115                 120                 125             


Phe Pro Ile Leu Gly Pro Ile Met Ala Asp Glu Ala Ala Tyr Lys Val 
    130                 135                 140                 


Asn Asn Ser Lys Lys Ser Asn Val Thr Asp Ala Tyr Thr Met Thr Tyr 
145                 150                 155                 160 


Gly Val Thr Leu Ser Asp Cys Leu Lys Val Leu Ser Thr Ile Ala Gln 
                165                 170                 175     


Gly Leu Val Asp Cys Arg Asn Thr Asp Val His Phe Lys Pro Tyr Asn 
            180                 185                 190         


Ser Leu Asp Asp Leu Ala Lys Gln Tyr Leu Val Gln Glu Asn Ile Val 
        195                 200                 205             


Arg Tyr Leu Ile Lys Ala Leu Val Ala Ser Arg Arg Leu Asp Lys Lys 
    210                 215                 220                 


Arg Asn Ser Ile Glu Thr Glu Lys Met Glu Phe Leu Thr Gly Tyr Ala 
225                 230                 235                 240 


Lys Asp Ser Asn Asp Asp Ala Gly Arg Ser Leu Glu Ser Tyr Ile Arg 
                245                 250                 255     


Lys Trp Gly Phe Tyr Pro Lys Tyr Asp Gln Val Ile Lys Thr Asp Glu 
            260                 265                 270         


Asn Gly Asn Val Leu Tyr Val Ile Glu Thr Asp Lys Gln Gly Asn Pro 
        275                 280                 285             


Lys Lys Asp Glu Lys Gly Asn Pro Val Tyr Lys Gln Lys Lys Asp Lys 
    290                 295                 300                 


Phe Gly Asn Trp Arg Phe Lys Glu Asp Gly Ser Pro Glu Tyr Glu Glu 
305                 310                 315                 320 


Gln Val Arg Met Val Glu Arg Asn Asp Phe Phe Tyr Lys Ile Gly Gly 
                325                 330                 335     


Asp Thr Ser Ile Val Lys Asp Gly Lys Val Tyr Ser Thr Leu Thr Gly 
            340                 345                 350         


Phe Gly Leu Ala Tyr Phe Cys Thr Ile Phe Leu Thr Lys Ser Gln Ala 
        355                 360                 365             


Lys Gln Met Leu Ser Asp Val Glu Leu Phe Glu Lys Ser Pro Tyr Pro 
    370                 375                 380                 


Lys Glu Leu Asn Asp Ile Ile Arg Asp Met Leu Ser Ile Tyr Arg Ile 
385                 390                 395                 400 


Arg Ser Pro Lys Gly Lys Lys Leu Glu Gly Ser Asp Thr Lys Ile Ser 
                405                 410                 415     


Leu Ala Leu Asp Met Leu Asn Glu Leu Arg Lys Cys Pro Lys Glu Leu 
            420                 425                 430         


Tyr Asp Val Leu Ser Pro Glu Gly Gln Lys Tyr Phe Glu Asp Lys Val 
        435                 440                 445             


Lys Arg Pro Asn Glu Arg Thr Pro Glu Val Val Lys Arg Phe Arg Ser 
    450                 455                 460                 


Thr Asp Arg Phe Pro Tyr Leu Ala Met Arg Tyr Ile Asp Glu Thr Lys 
465                 470                 475                 480 


Leu Phe Asp Asn Ile Arg Phe Gln Val Gln Leu Gly Lys Leu Arg Phe 
                485                 490                 495     


Lys Phe Tyr Pro Lys Thr Cys Ile Asn Gly Glu Glu Glu Ile Arg Ser 
            500                 505                 510         


Gln Gln Lys Glu Ile Asn Gly Phe Gly Arg Ile Gln Glu Ile Glu Gln 
        515                 520                 525             


Lys Arg Gln Thr Glu Tyr Gln Asp Phe Leu Gln Thr Ala Lys Glu Lys 
    530                 535                 540                 


Ser Val Lys Ile Glu Gly Glu Asp Ile Asn Leu Asp Leu Leu Gln Phe 
545                 550                 555                 560 


Glu Lys Asp Ser Ala Asp Ser Lys Pro Tyr Ile Thr Asp Ser Arg Ala 
                565                 570                 575     


Tyr Tyr Asn Ile His Asn Asn Arg Ile Gly Leu Leu Trp Lys Glu Lys 
            580                 585                 590         


Val Val Thr Asp Glu Glu Lys Asn Lys Arg Ile Ile Tyr Gln Tyr Gly 
        595                 600                 605             


Asp Tyr Met Pro Ser Leu Lys Asn Val Lys Asp Gly Lys Ala Pro Val 
    610                 615                 620                 


Thr Met Pro Ser Pro Met Ala Met Leu Ser Ile His Glu Leu Pro Ser 
625                 630                 635                 640 


Leu Ile Phe Tyr Asp Tyr Leu Leu Arg Val Thr Gly Asn Asp Asp Lys 
                645                 650                 655     


Glu Lys Ser Ala Glu Asn Ile Ile Ile Asp Lys Cys His Arg Leu Gln 
            660                 665                 670         


Lys Phe Phe Ser Asp Val Lys Ser Gly Thr Met Thr Pro Met Ala Asn 
        675                 680                 685             


Lys Glu Glu Leu Ala Lys Lys Leu Met Ser Glu Tyr Gly Leu Ala Val 
    690                 695                 700                 


Asn Asp Ile Pro Asp Lys Leu Lys Lys Tyr Leu Ser Gly Glu Ser Ile 
705                 710                 715                 720 


Asp Val Asn Arg Arg Lys Gln Glu Leu Thr Arg Asn Arg Leu Val Arg 
                725                 730                 735     


Met Leu Lys Arg Ala Ile Arg Arg Arg Asp Gly Phe Lys Asp Asp Arg 
            740                 745                 750         


Lys Met Val Gly Asn Lys Asp Asn Lys Tyr Gly Lys Asp Ser Tyr Val 
        755                 760                 765             


Asp Val Arg His Gly Ser Leu Ala Arg Tyr Leu Ser Glu Ser Phe Leu 
    770                 775                 780                 


Glu Trp Gln Pro Ser Asn Lys Lys Gly Asp Asn Lys Leu Thr Gly Met 
785                 790                 795                 800 


Asn Phe Ser Lys Leu Gln Ser Glu Leu Ala Val Phe Asp Asp Glu Gly 
                805                 810                 815     


Lys Tyr Gly Val Val Lys Glu Met Leu Glu Lys Ser Gly Leu Leu Ser 
            820                 825                 830         


Gly Asn Tyr Ala His Pro Phe Leu Asn Lys Met Thr Gly Lys Asn Ile 
        835                 840                 845             


Arg Asn Ile Glu Glu Leu Tyr Leu Leu Tyr Leu Asn Glu Glu Val Leu 
    850                 855                 860                 


Tyr Ile Lys Lys Leu Leu Gly Ile Lys Asp Lys Lys Asp Asn Asp Ile 
865                 870                 875                 880 


Thr Asp Asn Lys Ile Asp Phe Lys Lys Ile Leu Leu Thr Pro Asp Val 
                885                 890                 895     


Tyr Asp His Leu Pro Phe Val Lys Gly Asp Ala Arg Trp Lys Glu Pro 
            900                 905                 910         


Thr Pro Glu Asn Ile Lys Gln Leu Ala Gly Arg Tyr Leu Glu Leu Asp 
        915                 920                 925             


Gly Lys Arg Ala Ser Ile Trp Leu Pro Asp Gly Leu Phe Gly Lys His 
    930                 935                 940                 


Ile Leu Glu Ile Leu Thr Thr His Phe Ala Asp Asn Lys Gln Leu Gln 
945                 950                 955                 960 


Glu Asp Leu Ser Asp Glu Asn Leu Thr Thr Ser Val Ser Tyr Leu Ile 
                965                 970                 975     


Arg Val Phe Phe Glu Asp Gln Leu Ser Asp Ser Cys Gln Pro Phe Tyr 
            980                 985                 990         


Val Thr Thr Lys Thr Asp Gly Glu  Asn Leu Arg Arg Thr  Lys Phe Ala 
        995                 1000                 1005             


His Ile  Tyr Asp Leu Phe Asn  Ile Leu Asn Asn Lys  Lys Val Arg 
    1010                 1015                 1020             


Asn Ala  Tyr Ile Lys Val Pro  Lys Ile Val Glu Glu  Ile Asn Asp 
    1025                 1030                 1035             


Leu Phe  Val Ile Tyr Ala Glu  Asp Lys Asn Gly Asn  Leu Ile Lys 
    1040                 1045                 1050             


Arg Ile  Gly Leu Asp Gly Lys  Pro Leu Lys Asp Glu  Asn Gly Lys 
    1055                 1060                 1065             


Thr Leu  Tyr Lys Lys Leu Ile  His Val Glu Ile Asp  Lys Arg Ile 
    1070                 1075                 1080             


Asp Glu  Met Thr Tyr Lys Glu  Arg Gly Asn His Lys  Thr Leu Asp 
    1085                 1090                 1095             


Glu Ala  Lys Asp Ala Met Arg  Arg Lys Leu Ile Arg  Met Ile Gly 
    1100                 1105                 1110             


Glu Val  Lys Asp Asn Glu Lys  Thr Ile Arg Arg Tyr  Lys Ala Gln 
    1115                 1120                 1125             


Asp Met  Val Met Phe Leu Met  Ala Glu Arg Met Met  Glu Glu Ser 
    1130                 1135                 1140             


Glu Ala  Thr Gly Asn Val Ser  Lys Ser Glu Lys Phe  Lys Leu Gln 
    1145                 1150                 1155             


Asn Val  Cys Tyr Pro Asp Phe  Leu Ser Gln Thr Val  Asn Phe Glu 
    1160                 1165                 1170             


Leu Pro  Phe Lys Val Gly Glu  Asp Thr Val Ile Ile  Ser Gln Glu 
    1175                 1180                 1185             


Phe Ile  Ser Leu Lys Asn Leu  Gly Glu Phe Tyr Gln  Leu Leu Ser 
    1190                 1195                 1200             


Asp Glu  Arg Leu Pro Ser Leu  Leu Glu Arg Leu Leu  Glu Ile Lys 
    1205                 1210                 1215             


Lys Arg  Glu Gln Lys Glu Pro  Asn Phe Gly Tyr Ser  Glu Ile Met 
    1220                 1225                 1230             


Gly Glu  Leu Ala Ser Tyr Asp  Ile His Arg Ser Arg  Ile Phe Lys 
    1235                 1240                 1245             


Ala Ile  His Gln Leu Glu Lys  Tyr Val Val Ser Asn  Ser Glu Phe 
    1250                 1255                 1260             


Arg Glu  Phe Leu Asn Asn Pro  Asn Asp Lys Arg Phe  Tyr Ile Lys 
    1265                 1270                 1275             


Asp Asp  Asn Thr Gln Asp Pro  Lys Arg Asn Asn Phe  Arg Ser Leu 
    1280                 1285                 1290             


Leu Glu  Leu Leu Glu Glu Gly  Asp Ile His Val Leu  Ser Lys Asp 
    1295                 1300                 1305             


Glu Arg  Glu Leu Ile Ile Ser  Ile Arg Asn Ala Phe  Ser His Asn 
    1310                 1315                 1320             


His Tyr  Gly Ile Asn Phe Asp  Asp Ile Ala Asp Asp  Lys Asp Leu 
    1325                 1330                 1335             


Gly Lys  Ser Thr Leu Leu Tyr  Ile Glu Glu Glu Thr  Ala Ser Asp 
    1340                 1345                 1350             


Ala Asn  Lys Lys Glu Leu Thr  Thr Ile Ala Thr Leu  Ile Ala Lys 
    1355                 1360                 1365             


Lys Leu  Glu Glu Leu Gln Gln  Lys Val Glu Lys Ser  Asn Tyr Ser 
    1370                 1375                 1380             


<210>  1759
<211>  1146
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1759

Met Glu Ser Ile Ile Gly Leu Gly Leu Ser Phe Asn Pro Tyr Lys Thr 
1               5                   10                  15      


Ala Asp Lys His Tyr Phe Gly Ser Phe Leu Asn Leu Ala Asp Asn Asn 
            20                  25                  30          


Leu Lys Ala Val Phe Ala Glu Phe Lys Glu Arg Ile Ser Asp Lys Ser 
        35                  40                  45              


Lys Asp Glu Asp Ile Ser Asn Leu Ile Glu Lys His Phe Ile Asp Asn 
    50                  55                  60                  


Met Ser Ile Val Asp Tyr Glu Lys Asn Ile Ser Ile Leu Asn Gly Tyr 
65                  70                  75                  80  


Leu Pro Ile Ile Asp Phe Leu Asp Asp Glu Leu Glu Asn Asn Leu Asn 
                85                  90                  95      


Thr Arg Val Lys Asn Phe Lys Lys Ser Phe Ile Ile Leu Ala Glu Ala 
            100                 105                 110         


Leu Glu Thr Leu Arg Asn Tyr Tyr Thr His Phe Tyr His Asp Pro Ile 
        115                 120                 125             


Thr Phe Gly Asp Asn Lys Glu Pro Leu Leu Glu Leu Leu Asp Glu Val 
    130                 135                 140                 


Leu Leu Lys Thr Ile Leu Asp Val Lys Lys Lys Tyr Leu Lys Thr Asp 
145                 150                 155                 160 


Lys Thr Lys Glu Ile Leu Lys Asp Ser Leu Arg Glu Glu Met Asp Leu 
                165                 170                 175     


Leu Val Ile Arg Lys Thr Asp Glu Leu Arg Glu Lys Lys Lys Thr Asn 
            180                 185                 190         


Pro Lys Phe Lys Phe Ser Thr Asp Pro Thr Gln Ile Arg Asn Ser Ile 
        195                 200                 205             


Phe Asn Asp Ala Phe Gln Gly Leu Leu Tyr Glu Asp Lys Glu Asn Asn 
    210                 215                 220                 


Gly Lys Thr Gln Val Ser Tyr Arg Ala Lys Thr Lys Leu Asn Pro Lys 
225                 230                 235                 240 


Asp Ile His Lys Gln Glu Glu Arg Asp Phe Glu Ile Pro Leu Ser Thr 
                245                 250                 255     


Ser Gly Ile Val Phe Leu Met Ser Leu Phe Leu Ser Lys Lys Glu Ile 
            260                 265                 270         


Glu Asp Phe Lys Ser Asn Ile Lys Gly Phe Lys Gly Lys Val Val Lys 
        275                 280                 285             


Asp Glu Asn His Asn Ser Leu Lys Tyr Met Ala Thr His Arg Val Tyr 
    290                 295                 300                 


Ser Ile Leu Ala Phe Lys Gly Leu Lys Tyr Arg Ile Lys Thr Asp Thr 
305                 310                 315                 320 


Phe Ser Lys Val Thr Leu Met Met Gln Met Ile Asp Glu Leu Ser Lys 
                325                 330                 335     


Val Pro Asp Cys Val Tyr Gln Asn Leu Ser Glu Thr Lys Gln Lys Asp 
            340                 345                 350         


Phe Ile Glu Asp Trp Asn Glu Tyr Leu Lys Asp Asn Glu Glu Asn Thr 
        355                 360                 365             


Glu Asn Leu Glu Asn Ser Arg Val Val His Pro Leu Ile Arg Lys Arg 
    370                 375                 380                 


Tyr Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe 
385                 390                 395                 400 


Ala Asn Phe Lys Thr Leu Lys Phe Gln Val Phe Met Gly Tyr Tyr Ile 
                405                 410                 415     


His Asp Gln Arg Thr Lys Thr Ile Gly Thr Thr Asn Ile Thr Thr Glu 
            420                 425                 430         


Arg Thr Val Lys Glu Lys Ile Asn Val Phe Gly Lys Leu Ser Lys Met 
        435                 440                 445             


Asp Asn Leu Lys Lys His Phe Phe Ser Gln Leu Ser Asp Glu Glu Asn 
    450                 455                 460                 


Thr Asp Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Phe Leu Thr Gln 
465                 470                 475                 480 


Ala Asp Asn Ser Pro Ala Asn Asn Ile Pro Ile Tyr Leu Glu Leu Lys 
                485                 490                 495     


Asn Gln Gln Ile Ile Lys Glu Lys Asp Asp Ile Lys Ala Glu Val Asn 
            500                 505                 510         


Asn Ser Gln Asn Arg Asn Pro Asn Lys Pro Ser Lys Arg Asp Leu Leu 
        515                 520                 525             


Asn Lys Ile Ser Asn Thr Asn Glu Asp Phe Tyr Gln Gly Asp Pro Thr 
    530                 535                 540                 


Ala Ile Leu Ser Leu Asn Glu Ile Pro Ala Leu Leu His Leu Phe Leu 
545                 550                 555                 560 


Val Gln Pro Asp Asn Lys Thr Gly Gln Gln Ile Glu Asn Ile Ile Arg 
                565                 570                 575     


Ile Lys Ile Glu Lys Gln Phe Asn Ser Ile Lys Asn Pro Ser Lys Asp 
            580                 585                 590         


Asp Lys Gly Val Pro Lys Ser Leu Phe Ala Asp Thr Asn Val Arg Val 
        595                 600                 605             


Asn Ala Ile Lys Leu Lys Lys Asp Leu Gly Glu Glu Leu Asp Met Leu 
    610                 615                 620                 


Asn Lys Lys Gln Ile Val Phe Lys Glu Asn Gln Lys Ala Ser Ser Asn 
625                 630                 635                 640 


Tyr Asp Glu Leu Leu Lys Lys His Gln Phe Thr Pro Lys Asn Lys Arg 
                645                 650                 655     


Pro Ala Leu Arg Lys Tyr Val Phe Tyr Asn Ser Glu Lys Gly Glu Glu 
            660                 665                 670         


Ala Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Lys Gly Phe 
        675                 680                 685             


Lys Thr Lys Trp Lys Gly Tyr Gln His Ser Glu Leu Gln Arg Lys Leu 
    690                 695                 700                 


Ala Phe Tyr Asp Arg His Thr Lys Gln Asp Ile Lys Glu Leu Leu Ser 
705                 710                 715                 720 


Gly Cys Glu Phe Asp His Phe Leu Leu Asp Ile Asn Ala Cys Phe Lys 
                725                 730                 735     


Glu Asp Asp Phe Glu Asp Phe Phe Ser Lys Tyr Leu Lys Asn Arg Ile 
            740                 745                 750         


Glu Thr Leu Asn Ile Ile Leu Lys Gln Leu His Asp Phe Lys Asn Glu 
        755                 760                 765             


Pro Thr Pro Leu Lys Gly Val Phe Lys Asn Cys Leu Lys Phe Leu Lys 
    770                 775                 780                 


Gln Lys Asn Tyr Val Thr Glu Asn Pro Glu Ile Ile Lys Lys Arg Ile 
785                 790                 795                 800 


Leu Ala Lys Pro Ala Phe Leu Pro Arg Gly Ile Phe Asp Glu Arg Pro 
                805                 810                 815     


Thr Met Lys Lys Gly Lys Asn Pro Leu Ile Asp Arg Asp Glu Phe Ala 
            820                 825                 830         


Lys Trp Phe Val Glu Tyr Leu Glu Asn Lys Asp Tyr Gln Lys Phe Tyr 
        835                 840                 845             


Asn Ser Glu Glu Tyr Arg Ile Arg Asp Ala Asp Phe Lys Lys Asn Ala 
    850                 855                 860                 


Val Ile Lys Lys Gln Lys Leu Lys Asp Phe Tyr Thr Leu Gln Met Val 
865                 870                 875                 880 


Asn Tyr Leu Leu Lys Glu Val Phe Gly Lys Asp Glu Met Asn Leu Gln 
                885                 890                 895     


Leu Ser Glu Leu Phe Gln Thr Arg Gln Glu Arg Leu Lys Leu Gln Gly 
            900                 905                 910         


Ile Ala Lys Lys Gln Met Asn Lys Glu Thr Gly Asp Ser Ser Glu Asn 
        915                 920                 925             


Thr Arg Asn Gln Thr Tyr Ile Trp Asn Lys Asp Val Pro Val Ser Phe 
    930                 935                 940                 


Phe Asn Gly Lys Val Thr Ile Asp Lys Val Lys Leu Lys Asn Ile Gly 
945                 950                 955                 960 


Lys Tyr Lys Arg Tyr Glu Arg Asp Glu Arg Val Lys Thr Phe Ile Gly 
                965                 970                 975     


Tyr Glu Val Asp Glu Lys Trp Met Met Tyr Leu Pro His Asn Trp Lys 
            980                 985                 990         


Asp Arg Tyr Ser Val Lys Pro Ile  Asn Val Ile Asp Leu  Gln Ile Gln 
        995                 1000                 1005             


Glu Tyr  Glu Glu Ile Arg Ser  His Glu Leu Leu Lys  Glu Ile Gln 
    1010                 1015                 1020             


Asn Leu  Glu Gln Tyr Ile Tyr  Asp His Thr Thr Asp  Lys Asn Thr 
    1025                 1030                 1035             


Leu Leu  Gln Asp Gly Asn Pro  Asn Phe Lys Met Tyr  Val Leu Asn 
    1040                 1045                 1050             


Gly Leu  Leu Thr Gly Ile Lys  Gln Val Asn Ile Ala  Asp Phe Ile 
    1055                 1060                 1065             


Val Leu  Lys Gln Asn Thr Asn  Phe Asp Lys Ile Asp  Phe Thr Gly 
    1070                 1075                 1080             


Ile Ala  Ser Cys Ser Glu Leu  Glu Lys Lys Thr Ile  Ile Leu Ile 
    1085                 1090                 1095             


Ala Ile  Arg Asn Lys Phe Ala  His Asn Gln Leu Pro  Asn Lys Thr 
    1100                 1105                 1110             


Ile Tyr  Asp Leu Ala Asn Glu  Phe Leu Lys Lys Glu  Lys Arg Glu 
    1115                 1120                 1125             


Thr Tyr  Ala Asn Tyr Tyr Leu  Lys Val Leu Lys Lys  Met Ile Ser 
    1130                 1135                 1140             


Asp Leu  Ala 
    1145     


<210>  1760
<211>  1147
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1760

Met Glu Ile Ala Thr Gln Gln Ser Glu Thr Gln Lys Lys Lys Arg Ser 
1               5                   10                  15      


Leu Asp Gln Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg 
            20                  25                  30          


His Asn Val Phe Leu Ile Val Asn His Leu Thr Asp Thr Phe Lys Glu 
        35                  40                  45              


Leu Asn Phe Lys Lys Leu Ala Asn Glu Glu Asp Ile Trp Lys Val Asp 
    50                  55                  60                  


Asn Ser Ser Asn Ile Leu Leu Asn Val Phe Asp Val Thr Gln Ser Lys 
65                  70                  75                  80  


Tyr Glu Asp Phe Arg Pro Arg Ile Phe His Tyr Leu Ile Lys Arg His 
                85                  90                  95      


His Leu Pro Leu Val Lys Ile Phe Asn Thr Glu Tyr Leu Gly Glu Asn 
            100                 105                 110         


Ile Leu Gln Asp Lys Ser Ile Asp Tyr Glu Arg Leu His Gln Phe Leu 
        115                 120                 125             


Cys Leu Ser Phe Lys Glu Leu Thr Glu Phe Arg Asn Ser Tyr Ser His 
    130                 135                 140                 


Ser Ile Ala Ile Asp Glu Asn Gly Asn Lys Val Gly Arg Lys Thr Thr 
145                 150                 155                 160 


Leu Ala Asn Asp Leu Val Pro Glu Val Asn Leu Leu Phe Lys Tyr Ala 
                165                 170                 175     


Pro Lys Tyr Ser Phe Leu Arg Asn His Gln Thr Leu Asn Glu Gly Asp 
            180                 185                 190         


Phe Gln His Leu Asp Asn Tyr Gln Leu Phe Ile Ala Asp Asn Gln Leu 
        195                 200                 205             


Thr His Gln Gly Arg Phe Phe Phe Ile Asn Leu Phe Leu Glu Arg Ser 
    210                 215                 220                 


Tyr Gly Ile Lys Phe Leu Lys Arg Phe Arg Gly Phe Lys Asn Glu Asn 
225                 230                 235                 240 


Thr Pro Pro Phe Lys Ala Thr Ile Gln Ser Phe Thr Thr Tyr Cys Leu 
                245                 250                 255     


Lys Val Pro Asp Ile Arg Leu Gly Asn Glu Asn Pro Lys Gln Ser Leu 
            260                 265                 270         


Leu Leu Asp Met Leu Thr Glu Leu Asn Lys Cys Pro Lys Glu Leu Phe 
        275                 280                 285             


Asn His Leu Thr Glu Asp Asp Lys Lys Glu Phe Glu Pro Asn Leu Asp 
    290                 295                 300                 


Glu Thr Ser Ser Thr Asn Val Leu Leu Asn Ser Thr Asn Tyr Glu Phe 
305                 310                 315                 320 


Phe Asp Thr Asp Glu Val Glu Glu Ala Ile Arg Glu Leu Thr Ala Gln 
                325                 330                 335     


Lys Arg His Ser Asp Arg Phe Pro Tyr Leu Ala Leu Arg Phe Leu Asp 
            340                 345                 350         


Glu Thr Met Ala Phe Ser Gln Leu Arg Phe Gln Leu Ser Leu Gly Lys 
        355                 360                 365             


Ile Ile Ile Lys Lys Pro Tyr Gln Lys Thr Ile Leu Gly Gln Pro Asn 
    370                 375                 380                 


Asp Arg Ile Ile Thr Lys Lys Leu Asn Val Phe Gly Arg Ile Ser Asp 
385                 390                 395                 400 


Phe Leu Asn Arg Glu Lys Glu Ile Ile Arg Ala Leu Ser Asn Asp Gln 
                405                 410                 415     


Asn Val Asp Phe Leu Glu Phe Glu Gln Phe Phe Pro His Tyr Asn Ile 
            420                 425                 430         


Asn Asn Asn Lys Ile Ala Phe Tyr Phe Leu Asn Asp Ser Asp Leu Thr 
        435                 440                 445             


Glu Glu Asn Leu Glu Ser Arg Leu Arg Asp Gln Glu Asn Arg Gln Pro 
    450                 455                 460                 


Thr Gly Phe Leu Ser Ile His Asp Leu Pro Lys Leu Val Leu Leu His 
465                 470                 475                 480 


Leu Leu Ala Pro Ser Glu Val Gln Lys Thr Leu Gln Arg Phe Ile Asn 
                485                 490                 495     


Asp Asn Asn Pro Ala Phe Phe Asp Leu Glu Leu Leu Ala Asn Ile Lys 
            500                 505                 510         


Ser Lys Val Val Tyr Glu Pro Ser Thr Phe Thr Lys Arg Ser Glu His 
        515                 520                 525             


Gln Tyr Arg Asp Ala Asp Lys Gln Glu Glu Glu Thr Glu Lys Gln Gln 
    530                 535                 540                 


Glu Tyr Gln Thr Leu Leu Asn Gln Arg Lys Arg Leu Leu Glu Gln His 
545                 550                 555                 560 


Leu Pro Lys Gly Val Lys Ile Asn Gln Ile Pro Glu Lys Val Leu Asp 
                565                 570                 575     


Phe Leu Met Asn Ile Ser Glu Pro Asn Glu Asn Lys Val Ile His Gln 
            580                 585                 590         


Lys Ile Lys Ser Ile Lys Asp Glu Ala Lys Thr Leu Leu Gln Arg Val 
        595                 600                 605             


Lys Asn Lys Gln Ala Ala Asn Glu Ile Pro Lys Leu Gly Glu Leu Ala 
    610                 615                 620                 


Thr Phe Leu Thr Arg Asp Ile Ile Asn Met Val Val Ser Glu Glu Leu 
625                 630                 635                 640 


Lys Lys Lys Ile Thr Ser Pro Tyr Ser Asn Lys Leu Gln Asn Lys Ile 
                645                 650                 655     


Ala Phe Phe Ser Leu Ser Lys Gln Glu Ile Ile Ser Leu Leu Ser Glu 
            660                 665                 670         


Leu Gln Leu Leu Asn Asn Glu Lys Gly His Val Phe Leu Ser Ser Arg 
        675                 680                 685             


Leu Ile Leu Glu Ser Asn Gly Leu Leu Ser Phe Tyr Lys Ser Tyr Leu 
    690                 695                 700                 


Glu Ala Lys Ile Ala Trp Ile Asp Lys Asn Leu Phe Leu Lys Gly Lys 
705                 710                 715                 720 


Lys Gly Gly Tyr Ile Ile Pro Glu Asn Lys Pro Val Pro Lys Thr Leu 
                725                 730                 735     


Gln Lys Ile Lys Gln Glu Val Ser Gln Phe Asp Phe Thr Gln Trp Leu 
            740                 745                 750         


Gln Asn Lys Ala Ala Met Pro Ile Asp Val Pro Asn Thr Ile Phe Asp 
        755                 760                 765             


Val Ser Leu Glu Asn Leu Leu Lys Thr Asn Leu Lys Lys Arg Gly Ile 
    770                 775                 780                 


Thr Val Lys Asp Thr Asp Lys Phe Ser Val Leu Leu Asn Lys Tyr Leu 
785                 790                 795                 800 


Asp Lys Asp Thr Gln Pro Phe Tyr Lys Tyr Gly Arg Val Tyr Lys Ile 
                805                 810                 815     


Gln Asp Glu Glu Glu Ser Val Gln Val Val Gly Lys Met Ser Lys Thr 
            820                 825                 830         


Leu Lys Lys Gln Tyr Gly Lys Phe Val Glu Glu Asn Glu Lys Val Ile 
        835                 840                 845             


Arg Phe Tyr Gln Ser Lys Asp Arg Val Ile Lys Leu Met Cys Asn Ala 
    850                 855                 860                 


Leu Leu Gln Ala Glu Asn Lys Thr Ala Leu Thr Asp Ser Phe Lys Leu 
865                 870                 875                 880 


Ala His Thr His Pro Asn Ser Lys Gln Asn Pro Leu Asp Thr Pro Met 
                885                 890                 895     


Arg Phe Glu Gln Lys Leu Phe Ser Asn Asp Lys Glu Thr Lys Val Leu 
            900                 905                 910         


Cys Thr Ile Tyr Ala Gln Asp Thr Glu Asn Gln Lys Asn Glu Ile Leu 
        915                 920                 925             


Ala Trp Asn Ser Leu Ser Glu Asp Asp Lys Lys Tyr Trp Leu Thr Leu 
    930                 935                 940                 


Thr Thr Lys Glu Ala Gln Lys Glu Trp Leu Ser Gly Lys Pro Glu Thr 
945                 950                 955                 960 


Glu Gln Glu Val Tyr His Gly Gln Lys Gly Tyr Gln Trp Thr Ile Lys 
                965                 970                 975     


Glu Val Gly Lys Phe Lys Arg Phe Val Lys Asp Arg Arg Ile Pro Ala 
            980                 985                 990         


Leu Val Asn Tyr Phe Glu Thr Thr  Lys Leu Pro Phe Ser  Leu Leu Glu 
        995                 1000                 1005             


Tyr Gln  Leu Lys Glu Tyr Asp  Arg Val Arg Glu Gln  Ile Phe Asp 
    1010                 1015                 1020             


Gly Val  Phe Lys Leu Glu Glu  Ala Ile Ser Gln Lys  Asp Leu Ala 
    1025                 1030                 1035             


Gly Ile  Trp Ala Leu Glu Gln  Glu Ala Arg Gly Arg  Lys Asn Tyr 
    1040                 1045                 1050             


His Gln  Val Gln Phe Asn Ile  Phe Glu Lys Tyr Leu  Gln Asn Thr 
    1055                 1060                 1065             


Leu Pro  Ser Tyr Asp Pro Ala  Ile Gly Val Ile Arg  Asn Lys Phe 
    1070                 1075                 1080             


Ser His  Asn Glu Phe Pro Asp  Leu Ile Gly Gln Gly  Ile Glu Lys 
    1085                 1090                 1095             


Ile Ser  Gln Ala Gln Ile Asp  Asp Tyr Gln Arg Asn  Lys His Leu 
    1100                 1105                 1110             


Lys Asp  Tyr Leu Ala His Ala  Gly Ile Ser Ile Ala  Gln Gln Ile 
    1115                 1120                 1125             


Leu Ala  Ile Phe Glu Gln Lys  Ile Asn Asp Thr Leu  Thr Gln Leu 
    1130                 1135                 1140             


Thr Thr  His Gly 
    1145         


<210>  1761
<211>  1313
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1761

Met Glu Lys Lys Gln Lys His Gln Gln Pro Ile Lys Asn Gln Asn Ser 
1               5                   10                  15      


Glu Asn His Tyr Ala Gly Ser Lys Pro Thr Lys Lys Tyr Gln Arg Arg 
            20                  25                  30          


Ser Pro Asn Ser Ile Gln Pro Glu Ala Asn Ser Lys Lys Leu Arg Pro 
        35                  40                  45              


Val Phe Ala Ala Tyr Leu Asn Met Ala Arg Ala Asn Leu Tyr Ala Val 
    50                  55                  60                  


Leu Arg His Ile Ser Val Ile Thr Gly Leu Asn Val Asn Lys Asp Glu 
65                  70                  75                  80  


Glu His Met Glu Gln Leu Pro Val Ser Arg Phe Ala Asn Gln Lys His 
                85                  90                  95      


Pro Glu Val Arg Gln Lys Val Tyr Thr Leu Leu Tyr Lys His Ile Pro 
            100                 105                 110         


Cys Leu Lys His Met Ser Gln Ala Tyr Ile Lys Lys Gly Lys Leu Asp 
        115                 120                 125             


Leu Asp Gly Asn Pro Ile Val Glu Glu His Lys Thr Val Thr Gln Ser 
    130                 135                 140                 


Asp Leu Gln Lys Leu Leu Gln Asn Ile Ile Arg Thr Leu Asn Tyr Gln 
145                 150                 155                 160 


Arg Asn Glu Phe Thr His Ala Asp His Tyr Asn Thr Glu Asn Glu Arg 
                165                 170                 175     


Glu Ala Glu Phe Lys Arg Gln Ser Asp Leu Phe Arg Pro Leu Ser Cys 
            180                 185                 190         


Ala Phe Ile Gly Ala Lys Arg Glu Thr Ser Arg Ile Phe Asn Tyr Asn 
        195                 200                 205             


Ala Asp Asp Met Phe Phe Ile Asp Gln Lys Glu Arg Met Glu Arg Thr 
    210                 215                 220                 


Asn Glu Leu Asn Glu Asp Gly Lys Pro Ile Tyr Arg Glu His Glu Asp 
225                 230                 235                 240 


Trp Tyr Phe Arg Leu Phe Thr Arg Ser Ala Lys Tyr Ile Arg Asn Asp 
                245                 250                 255     


Gln Gly Asp Ile Glu Ile Asn Asp Asp Asp Gly Ile Ile Gly Glu Asn 
            260                 265                 270         


Glu Ser Leu Gln Leu Thr Ser Ala Gly Leu Ile Phe Leu Ile Cys Lys 
        275                 280                 285             


Phe Leu His Lys Lys Tyr Ala Thr Gln Phe Ala Gln Gln Thr Gly Leu 
    290                 295                 300                 


Phe Arg Thr Arg Gly Gln Ser Gly Asn Ser Pro Phe Ser Ile Arg Glu 
305                 310                 315                 320 


Asn Glu Val Met Phe Asn Ile Phe Cys Ala His Arg Ile Arg Leu Pro 
                325                 330                 335     


Lys Gly Arg Ile Glu Ser Asn Thr Asp Lys Ser Ala Leu Gly Leu Asp 
            340                 345                 350         


Met Leu Asn Glu Leu Gln Lys Cys Pro Lys Glu Leu Phe Glu Thr Phe 
        355                 360                 365             


Ser Pro Ala Asp Arg Ser Leu Phe Gln Ile Val Arg Asn Gly Asn Thr 
    370                 375                 380                 


Asn Thr Pro Asn Pro Asp Asp Asp Val Asn Leu Phe Arg Arg Asn Asn 
385                 390                 395                 400 


Asp Arg Phe Ala Gln Leu Ala Leu Lys Tyr Ile Asp Ser Leu Arg Thr 
                405                 410                 415     


Asp Pro Thr Glu Leu Ser Asp Thr Phe Glu Gly Pro Leu Lys Thr Ile 
            420                 425                 430         


Val Phe Gln Ile Ala Ile Gly Lys Tyr Arg Tyr Lys Phe Tyr Asn Arg 
        435                 440                 445             


Ala Ser Leu Asp Thr Asp Val Lys Asp Arg Val Arg Val Leu Gln Lys 
    450                 455                 460                 


Glu Val Asn Gly Phe Gly Pro Leu Ser Lys Ile Glu Glu Leu Arg Asp 
465                 470                 475                 480 


Gly Asp Asn His Lys Gly Gln Tyr Ser Ser Ile Ile Arg Arg Val Ser 
                485                 490                 495     


Asn Asn Glu Lys Gln Leu Tyr Ser Pro Asp Thr Ala Asp Thr Lys Pro 
            500                 505                 510         


Tyr Leu Thr Asp His His Ala Ser Tyr Ala Ile Thr Gly Asn Arg Ile 
        515                 520                 525             


Gly Leu Met Trp Asp Thr Thr Arg Glu Asn Gly Val Leu Asn Pro Asp 
    530                 535                 540                 


Thr Leu Cys Tyr Leu Pro Lys Leu Pro Leu Pro Glu Leu Asn Pro Lys 
545                 550                 555                 560 


Asn Asn Ser Trp Ser Val Asp Lys Ser Val Ile Glu Ser Asn Ala Val 
                565                 570                 575     


Pro Arg Ala Trp Leu Ser Ile Tyr Asp Leu Pro Ala Leu Ile Phe Leu 
            580                 585                 590         


His Leu Leu Gly Gly Asn Pro Glu Lys Val Ile Lys Glu Lys Tyr Lys 
        595                 600                 605             


Asn Leu Lys Lys Leu Phe Asn Asp Ile Ala His Asn Lys Phe Lys Pro 
    610                 615                 620                 


Ile Phe Ser Gly Glu Val Glu Ser Lys Cys Val Lys Arg Lys Gln Gln 
625                 630                 635                 640 


Ile Glu Cys Leu Lys Lys Gln Leu Glu Leu Ile Leu Ala Glu Lys Tyr 
                645                 650                 655     


Lys Gly Val Glu Leu Lys Asp Ile Pro Ala Lys Leu Thr Glu Tyr Leu 
            660                 665                 670         


Thr Ile Gly Ala Val Ser Asn Cys Asp Ser Val Asp Val Gln Phe Thr 
        675                 680                 685             


Lys Trp Ile Arg His Gln Leu Asn Gly Tyr Pro Ser Gln Ile Asp Asn 
    690                 695                 700                 


Asn Gly His Val Ala Ile Arg Ala Tyr Lys Gly Leu Ile Ala Ser Leu 
705                 710                 715                 720 


Glu Asp Arg Ile Ala Lys Phe Asn Gln Asp Leu Lys Ile Ile Gly Asp 
                725                 730                 735     


Lys Gln Asn Arg Leu Gly Arg Lys Ser Tyr Val Asp Val Arg Pro Gly 
            740                 745                 750         


Ser Leu Ala Arg Tyr Leu Ser Lys Asp Ile Val Arg Met Thr Ile Ala 
        755                 760                 765             


Asp Asn Gly Lys Asp Asn Gly Gly Lys Pro Thr Gly Leu Asp Phe Ala 
    770                 775                 780                 


Val Leu Gln Ser Ser Ile Ala Thr Tyr Asn Asn Asn Asn Glu Ile Phe 
785                 790                 795                 800 


Lys Lys Thr Leu Leu Gly Gln Met Leu Gln His Ala Ile Pro Leu Glu 
                805                 810                 815     


Asn His Pro Phe Leu Cys Asn Met Met Gly Met Lys Ile Lys Asp Thr 
            820                 825                 830         


Ile Ser Phe Tyr Leu Thr Tyr Gln Lys Gln Lys Leu Lys Trp Leu Lys 
        835                 840                 845             


Lys Arg Ala Glu Lys Glu Asp Phe Leu Gln Asn Ala His Phe Met Tyr 
    850                 855                 860                 


Phe Met Arg Glu Ser Tyr Arg Asn Phe Leu Ala Thr Ser Pro Asp Leu 
865                 870                 875                 880 


Val Ile Ser Ser Asp Gly Asn Glu Asn His Val Lys Gly Leu Ala Glu 
                885                 890                 895     


Arg Tyr Leu Asp Thr Leu Tyr Leu Pro Asp Gly Leu Phe Thr Asn Ala 
            900                 905                 910         


Ile Arg Lys Gln Leu Ala Glu Asn Glu Asp Thr Arg Glu Asn Pro Phe 
        915                 920                 925             


Ile Val Ala Ala Leu Lys Asp Glu Ile Lys Gly His Ser Ala Ala Tyr 
    930                 935                 940                 


Leu Leu Asn Val Tyr Phe Thr His Val Leu Asn Asp Lys Ser Gln Thr 
945                 950                 955                 960 


Phe Tyr Arg Asn Gln Gly Asp Leu Tyr Lys Arg His Tyr Lys Leu Leu 
                965                 970                 975     


Asp Ile Leu Tyr Pro Asn Ser Lys Gly Tyr Leu Thr Glu Asn Asp Leu 
            980                 985                 990         


Ala Val Lys Leu Lys Lys Cys Asp  Gly Asn Gln Ser Asn  Ile Arg Lys 
        995                 1000                 1005             


Lys Ile  Asn Ser His Val Glu  Asn Leu Glu Ile Val  Val Lys Lys 
    1010                 1015                 1020             


Tyr Asp  Arg Ser Glu Gly Arg  Lys Val Ser Tyr Tyr  Ala Pro Ala 
    1025                 1030                 1035             


Asp Glu  Glu Thr Lys Asn Asn  Glu Arg Ile Lys Leu  Met His Gln 
    1040                 1045                 1050             


Leu Arg  Asp Leu Gln His Asn  Glu Gln Val Ile Arg  Arg Tyr Arg 
    1055                 1060                 1065             


Asn Glu  Asp Met Leu Leu Phe  Leu Met Ala Gln Lys  Leu Leu Leu 
    1070                 1075                 1080             


Lys Gly  Gly Phe Val Phe Lys  Asn Lys Ala Asp Ala  Gly Gly Met 
    1085                 1090                 1095             


Gln Lys  Phe Arg Leu Gln Asp  Ile Thr Pro Pro Ala  Tyr Asn Val 
    1100                 1105                 1110             


Asp Asn  Lys Lys Ser Leu Leu  Asp Ile Pro Ile Asp  Phe Ser Ile 
    1115                 1120                 1125             


Thr Phe  Gly Leu Asn Asp Glu  Asn Gly His Ile Ile  Thr Gly Glu 
    1130                 1135                 1140             


Asp Gly  Lys Gln Ile Lys Arg  Thr Ile Arg Gln Lys  Asp Ile Lys 
    1145                 1150                 1155             


Ile Lys  Asn Tyr Gly Asp Phe  Phe Ala Phe Leu Tyr  Asp Ser Arg 
    1160                 1165                 1170             


Ile Gly  Gly Leu Leu Ser Gln  Leu Pro Leu Ser Ser  Asp Asp Ile 
    1175                 1180                 1185             


Ile Glu  Arg Ser Asp Leu Asp  Lys Glu Leu Asp Ile  Tyr Asp Arg 
    1190                 1195                 1200             


Lys Arg  Leu Lys Val Phe Ala  Val Leu Gln Ala Ile  Glu Arg Lys 
    1205                 1210                 1215             


Ile Ile  Asn Glu His Pro Glu  Leu Ala Asp Thr Asn  Ala Gly Gly 
    1220                 1225                 1230             


Ile Gly  Phe Tyr Asp Glu Gly  Gly Lys Pro Tyr Arg  Asn Ser Phe 
    1235                 1240                 1245             


Ser Gly  Leu Leu Ser Leu Cys  Lys Gln Tyr Met Ala  Asn Glu Lys 
    1250                 1255                 1260             


Asp Leu  Asn Asp Met Gly Tyr  Gly Ile Val Asp Ile  Arg Asn Ala 
    1265                 1270                 1275             


Phe Ser  His Asn Arg Tyr Thr  Ser Asp Asn Asn Lys  His Ile Asn 
    1280                 1285                 1290             


Ile Ser  Lys Met Asn Leu Pro  Gln Val Ala Glu Leu  Ile Leu Lys 
    1295                 1300                 1305             


Trp Leu  Glu Lys Ala 
    1310             


<210>  1762
<211>  1259
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1762

Met Glu Gln Pro Arg His Gln Glu Arg Lys Tyr Phe Thr Leu Glu Thr 
1               5                   10                  15      


Thr Pro Trp Tyr Phe Gly Ala Trp Leu Asn Gln Ala Arg His Asn Leu 
            20                  25                  30          


Ser Ile Val Leu Asn Asp Leu Ser Ile Lys Leu Gly Ser Lys Asp Ile 
        35                  40                  45              


Thr Asp Asp Ala Ser Leu Lys Ala Thr Lys Ala Val Arg Ile Leu Cys 
    50                  55                  60                  


Asp Ala Asn Ala Arg Pro Asp Asp Val Gln Lys Ala Leu Glu Tyr Tyr 
65                  70                  75                  80  


Glu Lys Lys Met Pro Phe Leu Phe Ala Met His Tyr Lys Phe Phe Lys 
                85                  90                  95      


Asn Glu Glu Leu Glu Asp Glu Ala Glu Lys Ile Asn Glu Met His Gly 
            100                 105                 110         


Asn Asn Leu Ser Ala Ser Pro Glu Gly Tyr Ala Ala Ile Leu His Gln 
        115                 120                 125             


Leu Ile Glu Val Leu Asn Ala Ala Arg Asn His Tyr Ser His Tyr Ala 
    130                 135                 140                 


Thr Thr Gly Glu Leu Ser Val Pro Glu Asp Phe Phe Tyr Leu Leu Asn 
145                 150                 155                 160 


Asp Ala Phe Asp Val Asn Val Arg Met Val Lys Arg Arg Phe Gly Leu 
                165                 170                 175     


Glu Glu Ser Asp Ile Asp His Leu Arg Arg Phe Ile Pro Asn Lys Asp 
            180                 185                 190         


Pro Asn Asn Lys Gly Arg Asn Gly Lys Lys Leu Lys Val Ile Pro Asn 
        195                 200                 205             


Pro Ala Phe Arg Tyr Arg Phe Asn Lys Lys Asp Ser Lys Thr His Phe 
    210                 215                 220                 


Ser Glu Phe Gly Leu Ala Phe Phe Cys Cys Leu Phe Leu Lys Pro Gly 
225                 230                 235                 240 


Asp Val Tyr Leu Phe Leu Lys Lys Ile Ser Gly Phe Lys Ala Gly Asp 
                245                 250                 255     


Thr Pro Ala Gln Lys Ala Ser Leu Asn Ala Tyr Cys Ile Asn Asn Leu 
            260                 265                 270         


Gln Leu Pro Leu Glu Arg Trp Glu Ser Asp Asn Ser Met Gln Ala Val 
        275                 280                 285             


Phe Leu Asp Met Cys Asn Glu Leu Ser Lys Ala Pro Lys Glu Leu Tyr 
    290                 295                 300                 


Asp Thr Leu His Pro Asp Lys Gln Gln Leu Phe Ile Thr Ser Arg Ala 
305                 310                 315                 320 


Ala Thr Glu Asp Glu Gln Glu Met Asp Asp Met Glu Glu Pro Glu Pro 
                325                 330                 335     


Glu Thr Lys Met Val Arg Lys His Asn Arg Phe Thr Phe Phe Ala Gln 
            340                 345                 350         


Arg Tyr Leu Asp Leu Thr Asn Ala Phe Pro Asn Leu Arg Phe Ala Val 
        355                 360                 365             


Asp Leu Gly Asn Phe His Tyr Ser Ile Tyr Pro Lys Val Ile Ala Gly 
    370                 375                 380                 


Asn Arg Glu Thr Arg His Leu Thr Lys His Leu Ile Gly Tyr Gly Lys 
385                 390                 395                 400 


Leu Glu Asp Phe Asp Val Lys Asn Arg Pro Pro Gln Tyr Ala Glu Lys 
                405                 410                 415     


Tyr Cys Thr Pro Glu Gln His Asn Gln Glu Met Pro Pro Gln Tyr Ile 
            420                 425                 430         


Pro Glu Ile Phe Pro His Tyr Gln Val Glu Asn Asn Leu Val Ala Ile 
        435                 440                 445             


Ser Ile Gly Glu Lys Asn Ala Cys Trp Pro Glu Leu Gln Thr Glu Ser 
    450                 455                 460                 


Thr Gly Gly Gln Arg Ser Tyr Pro Tyr Lys Tyr Ile Lys Ser Lys Glu 
465                 470                 475                 480 


Lys Arg Pro Asp Ala Tyr Ile Ser Thr His Glu Leu Pro Ala Leu Leu 
                485                 490                 495     


Phe Tyr Glu Leu Val Gln Asp Lys Lys Ser Gly Gln Glu Ile Ile Leu 
            500                 505                 510         


Gln His Met Arg Lys Val Arg Ala Phe Phe Ser Glu Ile Lys Ala Gly 
        515                 520                 525             


Met Val Gln Pro Val Ser Asn Ser Leu Leu Pro Lys Pro Gly Thr Ala 
    530                 535                 540                 


Asp Ile Val Glu Gly Lys Asn Arg Ala Tyr Asn Asp Arg Tyr Lys Ala 
545                 550                 555                 560 


Leu Glu Glu Leu Leu Lys Ser Arg His Leu Lys Ala Ala Trp Leu Pro 
                565                 570                 575     


Glu Lys Leu Leu His Tyr Leu Leu Gly Ile Glu Gln Lys Gly Glu Gln 
            580                 585                 590         


His Thr Lys Glu Ile Ala Val Gln Arg Leu Thr Asp Met Ile Thr Asp 
        595                 600                 605             


Ala Val Glu Lys Ile Glu Arg Met Glu Leu Arg Glu Lys Ser Ala Val 
    610                 615                 620                 


Lys Pro Gly Lys Lys Ala Phe Arg Lys Val Lys Val Gly Lys Leu Ala 
625                 630                 635                 640 


Asp Thr Leu Ser Ala Asp Met Met Gln Met Gln Pro Pro Val Lys Asn 
                645                 650                 655     


Ser Glu Gly Gln Pro Leu Pro Ser Ser Lys Ala Asn Thr Thr Ala Phe 
            660                 665                 670         


Arg Val Leu Gln Ser His Leu Ala Phe Tyr Gly Ala His Lys Asp Lys 
        675                 680                 685             


Leu Arg Asp Ile Phe Arg Ala Cys Lys Leu Ile Gly Gly Ile Asn Pro 
    690                 695                 700                 


His Pro Phe Leu His Arg Ile Asp Val Ser Gly Gln Thr Gly Ile Ile 
705                 710                 715                 720 


Glu Phe Tyr Lys Ala Tyr Phe Ile Glu Lys Val Lys Tyr Leu Asn His 
                725                 730                 735     


Cys Lys Lys Glu Arg Arg Tyr Ala Cys Tyr His Phe Leu Arg Leu Lys 
            740                 745                 750         


Asn Ala Ala His Asp Ile Pro His Leu Val Glu Glu Tyr Leu Asn Glu 
        755                 760                 765             


His Pro Glu Thr Gly His Cys Ala Phe Asn Leu Pro Arg Gly Leu Phe 
    770                 775                 780                 


Leu Gln Ala Ser Leu Asp Tyr Phe Lys Glu His Gly Ser Pro Val Met 
785                 790                 795                 800 


Gln Glu Tyr Ile Lys Leu His Ala Gly Arg Ile Asn Ser Val His Leu 
                805                 810                 815     


Ile Asn Tyr Tyr Phe Gln His Glu His Lys Asp Ala Ala Gln Asp Phe 
            820                 825                 830         


Tyr Ser Trp Pro Arg Gln Tyr Glu Leu Phe Lys Thr Pro Phe Ala Lys 
        835                 840                 845             


Asn Gly Tyr Asn Asp His Tyr Thr Ile Ala Glu Arg Thr Lys Arg Val 
    850                 855                 860                 


Pro Ala Leu Lys Glu Ile Ile Lys Ala Asp Glu Thr Gln Leu Ala Gln 
865                 870                 875                 880 


Leu Lys Ala Thr Ala Arg Ile Asp Lys Glu Glu Ile Val Ala Ala Leu 
                885                 890                 895     


Arg Ile Tyr Arg Gln Ile Arg Glu Met Asn Asn Tyr Leu Val Asp Arg 
            900                 905                 910         


Tyr Gln Lys Lys Tyr Pro Gly Met Ile Asp Leu His Arg Ala Arg Phe 
        915                 920                 925             


Ser Asn His Asp Asp Cys Arg Lys Val Val Ala Lys Ala Arg Ala Ile 
    930                 935                 940                 


Ile Asp Asp His Ile Asn Asn Val Glu Lys Arg Ile Arg Ser Tyr Arg 
945                 950                 955                 960 


Cys Phe Leu Glu Asn Glu Gln Tyr Leu Arg Leu Val Glu Val Gln Asp 
                965                 970                 975     


Lys Leu Leu Phe Leu Cys Ile Lys Lys Met Leu Ala Asn Ala Asp Asn 
            980                 985                 990         


Lys Leu Gln Leu Leu His Ala Asn  Glu Thr Thr Val Gln  Asn Gly Asp 
        995                 1000                 1005             


Thr Phe  Leu Leu Arg Asn Ile  Thr Ala Pro Asn Thr  Pro Gly Asn 
    1010                 1015                 1020             


Tyr Lys  Ser Met Leu Asn Cys  Lys Pro Val Asn Gly  Ile Ser Ile 
    1025                 1030                 1035             


Thr Leu  Pro Tyr Tyr Ala Val  Asn Glu Arg Gly Gly  Phe Lys Lys 
    1040                 1045                 1050             


Gln Glu  Gly Lys Lys Ile Leu  Leu Gly Glu Val Glu  Ile Phe Asp 
    1055                 1060                 1065             


Arg His  Leu Lys Ile Lys Asn  Asn Gly Asn Phe Arg  Lys Leu Leu 
    1070                 1075                 1080             


Lys Asp  Arg Arg Leu Asn Asn  Leu Cys Phe Tyr Phe  Met Pro Asp 
    1085                 1090                 1095             


Asn Glu  Gly Lys Ile Ser Leu  Glu Arg Asn Val Leu  Glu Asn Glu 
    1100                 1105                 1110             


Leu His  Ala Tyr Glu Arg Gln  Arg Leu Val Val Leu  Glu Lys Val 
    1115                 1120                 1125             


Ala Glu  Leu Glu Lys Ala Leu  Tyr Ser Lys His Glu  Asp Gln Ala 
    1130                 1135                 1140             


Val Asp  Leu Phe Tyr Asn Asn  Gly Arg Gln Glu His  Lys Arg Tyr 
    1145                 1150                 1155             


Leu Ala  Phe Tyr Phe Ala Gln  Tyr Ile Ser Gly Cys  Gln Glu Val 
    1160                 1165                 1170             


Gln Ala  Lys Leu Asn Ala Ile  Arg Asn Gly Phe Leu  His Asn Gln 
    1175                 1180                 1185             


Tyr Pro  Leu Ile Ala Glu Ala  Ala Phe Lys Ile Ala  Pro Glu Val 
    1190                 1195                 1200             


Trp Ala  Gln Gln Asn Ala Ala  Tyr Val Pro Ser Ala  Thr Gly Ser 
    1205                 1210                 1215             


Thr Lys  Gly Tyr Gly Leu Ile  Glu Lys Ile Ala Ala  Phe Ala Glu 
    1220                 1225                 1230             


Glu Gln  Tyr Ser Ile Met Ile  Ala Lys Ile Thr Gly  Cys Val Ser 
    1235                 1240                 1245             


Pro Pro  Leu Ala Gly Trp Leu  Gln Gln Gln Gly 
    1250                 1255                 


<210>  1763
<211>  1000
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1763

Met Glu Glu Ala Asn Arg Tyr Ile Tyr Gly Ala Tyr Phe Asn Met Ala 
1               5                   10                  15      


Arg Asp Asn Phe Leu Asn Thr Ile Lys Leu Leu Ala Asp Lys Met Lys 
            20                  25                  30          


Leu Gly Ala Ile Ser Gly Phe Gly Lys Asp Gly Asn Glu Val Asn Asp 
        35                  40                  45              


Ile Asn Lys Leu Phe Gly Asp Lys Asn Thr Tyr Ala Asn Ile Glu Asn 
    50                  55                  60                  


Val Val Glu Phe Tyr Phe Pro Trp Ile Lys Ala Leu Glu Gly Arg Phe 
65                  70                  75                  80  


Ser Leu Asp Lys Gly Asp Arg Asn Leu Asn Asp Met Lys Met Phe Tyr 
                85                  90                  95      


Lys Ser Val Leu Thr Ala Phe Phe Thr Ala Val Asp Ser Leu Arg Asn 
            100                 105                 110         


Lys Tyr Thr His Tyr Ser His Lys Asp Leu Asn Ile Arg Glu Ile Lys 
        115                 120                 125             


Ile Glu Cys Thr Leu Gly Gly Lys Asp Tyr Cys Ile Gly Leu Leu Asn 
    130                 135                 140                 


Ala Leu Asp Cys Ile Tyr Asp Ser Ala Val Asn Leu Leu Lys Leu Arg 
145                 150                 155                 160 


Phe Met Val Gly Glu Asp Glu Val Ala His Leu Arg Arg Cys Lys Ala 
                165                 170                 175     


Val Asn Lys Lys Val Val Val Arg Thr Glu Lys Asp Gly Phe Tyr Tyr 
            180                 185                 190         


Arg Leu Ser Asp Asn Gly Gly Val Thr Glu Lys Gly Val Ile Phe Ile 
        195                 200                 205             


Ala Ser Met Phe Leu Asn Arg Lys Tyr Gly Phe Leu Phe Leu Lys Gln 
    210                 215                 220                 


Leu Glu Gly Phe Lys Arg Ser Asp Glu Lys Arg Tyr Arg Leu Thr Leu 
225                 230                 235                 240 


Glu Ala Phe Leu Ala Phe Ser Asn Ile Lys Pro Val Asp Arg Leu Lys 
                245                 250                 255     


Ser Asp Lys Leu Asp Arg Ala Ser Leu Gly Leu Asp Met Leu Asn Glu 
            260                 265                 270         


Leu Thr Lys Ile Pro Lys Glu Leu Ser Glu Thr Leu Ser Val Asp Cys 
        275                 280                 285             


Leu Tyr Lys Tyr Leu Ala Ser Asp Gly Glu Asp Asp Leu Arg Ser Arg 
    290                 295                 300                 


Ile Arg Tyr Gln Asp Arg Phe Val Pro Leu Ala Leu Glu Phe Ile Ser 
305                 310                 315                 320 


Gln Ser Asp Glu Phe Lys Asp Phe Arg Phe Tyr Thr Tyr Val Gly Asn 
                325                 330                 335     


Tyr Val Tyr Lys Gly Tyr Ile Lys Arg Leu Ile Asp Gly Thr Asp Lys 
            340                 345                 350         


Glu Arg Tyr Leu Ser Asp Arg Leu Cys Gly Phe Tyr Lys Ser Val Asn 
        355                 360                 365             


Asp Ala Ser Ser Asp Ala Ile Ala Gln Lys Tyr Gly Val Glu Ile Lys 
    370                 375                 380                 


Asp Ser Asn Glu Pro Asp Tyr Met Leu Pro Asp Ser Phe Arg Pro His 
385                 390                 395                 400 


Val Leu Arg Ala Thr Pro His Phe Val Ile Asn Asn Asn Asn Ile Gly 
                405                 410                 415     


Ile Lys Ile Cys Gly Asn Asp Cys Leu Pro Ile Val Asn Gly Lys Gly 
            420                 425                 430         


Val Glu Ser Pro Glu Pro Asp Tyr Trp Leu Ser Ile Tyr Glu Leu Pro 
        435                 440                 445             


Ala Met Leu Phe Tyr Ala Tyr Leu Arg Glu Lys Asn Gly Lys Arg Phe 
    450                 455                 460                 


Lys Asp Tyr Lys Ser Ile Arg Glu Leu Ile Glu Gly Val Glu Lys Lys 
465                 470                 475                 480 


Ala Asp Glu Lys Asn Asp Arg Asp Lys Gly Ala Leu Met Ala Arg His 
                485                 490                 495     


Ile Asp Lys Glu Ile Ile Trp Thr Gln Thr Lys Leu Asp Glu Val Lys 
            500                 505                 510         


Arg Leu Glu Glu Lys Lys Val Ala Ala Tyr Gly Lys Lys Gly Arg Val 
        515                 520                 525             


Val Leu Lys Ser Gly Arg Met Ala Asp Leu Leu Ala His Asp Met Val 
    530                 535                 540                 


Arg Leu Gln Pro Ala Thr Lys Gly Ser Asp Lys Ile Thr Gly Val Asn 
545                 550                 555                 560 


Phe Gln Ala Leu Gln Val Ser Leu Ala Tyr Phe Lys Arg Asp Ile Leu 
                565                 570                 575     


Ala Asp Val Phe Ser Arg Ala Met Leu Thr Thr Gly Asn His Arg His 
            580                 585                 590         


Pro Phe Leu Tyr Arg Ile Asp Val Ser His Cys Ser Ser Leu Arg Asp 
        595                 600                 605             


Phe Tyr Val Ala Tyr Leu Gly Glu Arg Arg Lys Tyr Phe Glu Asp Val 
    610                 615                 620                 


Ala Lys Lys Ile Ala Lys Asn Lys Leu Asn Thr Pro Cys His Ile Leu 
625                 630                 635                 640 


Arg Arg Leu Gln Arg Glu Gly Ser Gly Glu Glu Ala Gly Lys Asp Val 
                645                 650                 655     


Lys Pro Lys Phe Leu Pro Arg Gly Ile Phe Thr Asp Ser Ile Lys Asn 
            660                 665                 670         


Cys Leu Glu Gln Ser Lys Leu Asn Ile Tyr Ile Arg Asn Ala Arg Asn 
        675                 680                 685             


Asp Val Lys Pro Ala Ile Asn Ala Ala Tyr Leu Ile Leu Met Tyr Tyr 
    690                 695                 700                 


Lys Glu Ile Glu Lys Gly Glu Phe Gln Gly Phe Tyr Gly Glu Lys Arg 
705                 710                 715                 720 


Arg Tyr Asp Ile Leu Glu Glu Gly Lys Pro Leu Asp Leu Ala Glu Arg 
                725                 730                 735     


Lys Lys Ala Leu Ala Ser Ile Lys Pro Ala Lys Ile Asp Val Ser Glu 
            740                 745                 750         


Ala Asn Met Pro Met Ser Lys Glu Glu His Leu Met Arg Lys Arg Tyr 
        755                 760                 765             


His Ala Val Cys Asn Asn Glu Ser Ala Ile Arg Met Tyr Gln Val Gln 
    770                 775                 780                 


Asp Ile Leu Leu Leu Leu Met Ala Lys Asp Ile Phe Lys Lys Ala Leu 
785                 790                 795                 800 


Ser Glu Gly Val Met Ser Lys Lys Ile Gly Leu Glu Asn Leu Asn Gly 
                805                 810                 815     


Ile Phe Asp Ala Pro Val Asn Phe Val Lys Asn Phe Asp Asn Ile Lys 
            820                 825                 830         


Leu Thr Ala Thr Gly Ile Lys Ile Lys Asn Tyr Gly Lys Val Cys Arg 
        835                 840                 845             


Leu Gly Thr Asp Phe Lys Phe Asn Ser Leu Ile Lys Ala Phe His Lys 
    850                 855                 860                 


Val Tyr Ser Lys Ser Val Glu Met Asp Tyr Ser Asp Tyr Leu Lys Glu 
865                 870                 875                 880 


Glu Glu Glu Phe Glu Lys Tyr Arg Leu Asn Met Val Lys Leu Cys Arg 
                885                 890                 895     


Glu Val Glu Arg Gly Ile Thr Glu Asp Leu His Leu Ser Leu Asp Gly 
            900                 905                 910         


Lys Ser His Leu Ser Phe Asn Asp Asp Val Ile Lys Pro Tyr Asn Asp 
        915                 920                 925             


Lys Tyr Asn Val Phe Asn Gly Asp Asp Leu Thr Phe Phe Ile Asn Ala 
    930                 935                 940                 


Arg Asn Met Phe Met His Gly Asp Tyr Lys Tyr Glu Cys Val Lys Tyr 
945                 950                 955                 960 


Val Val Ser Glu His Phe Lys Gly Ser Leu Asn Asp Val Ser Phe Ala 
                965                 970                 975     


Lys Glu Thr Tyr Gly His Phe Cys Asn Leu Leu Glu Ser Met Arg Lys 
            980                 985                 990         


Lys Thr Gly Leu Arg Ile Asp Ile  
        995                 1000 


<210>  1764
<211>  1165
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1764

Met Lys Asn Gln Asn Ser Leu Pro Ser Asn Pro Thr Asp Ile Leu Glu 
1               5                   10                  15      


Asp Lys Pro Phe Trp Ala Ala Phe Phe Asn Leu Ala Arg His Asn Val 
            20                  25                  30          


Tyr Leu Thr Val Asn His Ile Asn Lys Leu Leu Asp Leu Glu Lys Leu 
        35                  40                  45              


Tyr Asp Glu Gly Lys His Lys Glu Ile Phe Glu Arg Glu Asp Ile Phe 
    50                  55                  60                  


Asn Ile Ser Asp Asp Val Met Asn Asp Ala Asn Ser Asn Gly Lys Lys 
65                  70                  75                  80  


Arg Lys Leu Asp Ile Lys Lys Ile Trp Asp Asp Leu Asp Thr Asp Leu 
                85                  90                  95      


Thr Arg Lys Tyr Gln Leu Arg Glu Leu Ile Leu Lys His Phe Pro Phe 
            100                 105                 110         


Ile Gln Pro Ala Ile Ile Gly Ala Gln Thr Lys Glu Arg Thr Thr Ile 
        115                 120                 125             


Asp Lys Asp Lys Arg Ser Thr Ser Thr Ser Asn Asp Ser Leu Lys Gln 
    130                 135                 140                 


Thr Gly Glu Gly Asp Ile Asn Asp Leu Leu Ser Leu Ser Asn Val Lys 
145                 150                 155                 160 


Ser Met Phe Phe Arg Leu Leu Gln Ile Leu Glu Gln Leu Arg Asn Tyr 
                165                 170                 175     


Tyr Ser His Val Lys His Ser Lys Ser Ala Thr Met Pro Asn Phe Asp 
            180                 185                 190         


Glu Asp Leu Leu Asn Trp Met Arg Tyr Ile Phe Ile Asp Ser Val Asn 
        195                 200                 205             


Lys Val Lys Glu Asp Tyr Ser Ser Asn Ser Val Ile Asp Pro Asn Thr 
    210                 215                 220                 


Ser Phe Ser His Leu Ile Tyr Lys Asp Glu Gln Gly Lys Ile Lys Pro 
225                 230                 235                 240 


Cys Arg Tyr Pro Phe Thr Ser Lys Asp Gly Ser Ile Asn Ala Phe Gly 
                245                 250                 255     


Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys Gln Asp Ser Ile Trp 
            260                 265                 270         


Met Gln Lys Lys Ile Pro Gly Phe Lys Lys Ala Ser Glu Asn Tyr Met 
        275                 280                 285             


Lys Met Thr Asn Glu Val Phe Cys Arg Asn His Ile Leu Leu Pro Lys 
    290                 295                 300                 


Ile Arg Leu Glu Thr Val Tyr Asp Lys Asp Trp Met Leu Leu Asp Met 
305                 310                 315                 320 


Leu Asn Glu Val Val Arg Cys Pro Leu Ser Leu Tyr Lys Arg Leu Thr 
                325                 330                 335     


Pro Ala Ala Gln Asn Lys Phe Lys Val Pro Glu Lys Ser Ser Asp Asn 
            340                 345                 350         


Ala Asn Arg Gln Glu Asp Asp Asn Pro Phe Ser Arg Ile Leu Val Arg 
        355                 360                 365             


His Gln Asn Arg Phe Pro Tyr Phe Val Leu Arg Phe Phe Asp Leu Asn 
    370                 375                 380                 


Glu Val Phe Thr Thr Leu Arg Phe Gln Ile Asn Leu Gly Cys Tyr His 
385                 390                 395                 400 


Phe Ala Ile Cys Lys Lys Gln Ile Gly Asp Lys Lys Glu Val His His 
                405                 410                 415     


Leu Ile Arg Thr Leu Tyr Gly Phe Ser Arg Leu Gln Asn Phe Thr Gln 
            420                 425                 430         


Asn Thr Arg Pro Glu Glu Trp Asn Thr Leu Val Lys Thr Thr Glu Pro 
        435                 440                 445             


Ser Ser Gly Asn Asp Gly Lys Thr Val Gln Gly Val Pro Leu Pro Tyr 
    450                 455                 460                 


Ile Ser Tyr Thr Ile Pro His Tyr Gln Ile Glu Asn Glu Lys Ile Gly 
465                 470                 475                 480 


Ile Lys Ile Phe Asp Gly Asp Thr Ala Val Asp Thr Asp Ile Trp Pro 
                485                 490                 495     


Ser Val Ser Thr Glu Lys Gln Leu Asn Lys Pro Asp Lys Tyr Thr Leu 
            500                 505                 510         


Thr Pro Gly Phe Lys Ala Asp Val Phe Leu Ser Val His Glu Leu Leu 
        515                 520                 525             


Pro Met Met Phe Tyr Tyr Gln Leu Leu Leu Cys Glu Gly Met Leu Lys 
    530                 535                 540                 


Thr Asp Ala Gly Asn Ala Val Glu Lys Val Leu Ile Asp Thr Arg Asn 
545                 550                 555                 560 


Ala Ile Phe Asn Leu Tyr Asp Ala Phe Val Gln Glu Lys Ile Asn Thr 
                565                 570                 575     


Ile Thr Asp Leu Glu Asn Tyr Leu Gln Asp Lys Pro Ile Leu Ile Gly 
            580                 585                 590         


His Leu Pro Lys Gln Met Ile Asp Leu Leu Lys Gly His Gln Arg Asp 
        595                 600                 605             


Met Leu Lys Ala Val Glu Gln Lys Lys Ala Met Leu Ile Lys Asp Thr 
    610                 615                 620                 


Glu Arg Arg Leu Lys Leu Leu Asp Lys Gln Leu Lys Gln Glu Thr Asp 
625                 630                 635                 640 


Val Ala Ala Lys Asn Thr Gly Thr Leu Leu Lys Asn Gly Gln Ile Ala 
                645                 650                 655     


Asp Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Lys Arg Asp 
            660                 665                 670         


Lys Glu Gly Asn Pro Ile Asn Cys Ser Lys Ala Asn Ser Thr Glu Tyr 
        675                 680                 685             


Gln Met Leu Gln Arg Ala Phe Ala Phe Tyr Ala Thr Asp Ser Cys Arg 
    690                 695                 700                 


Leu Ser Arg Tyr Phe Thr Gln Leu His Leu Ile His Ser Asp Asn Ser 
705                 710                 715                 720 


His Leu Phe Leu Ser Arg Phe Glu Tyr Asp Lys Gln Pro Asn Leu Ile 
                725                 730                 735     


Ala Phe Tyr Ala Ala Tyr Leu Lys Ala Lys Leu Glu Phe Leu Asn Glu 
            740                 745                 750         


Leu Gln Pro Gln Asn Trp Ala Ser Asp Asn Tyr Phe Leu Leu Leu Arg 
        755                 760                 765             


Ala Pro Lys Asn Asp Arg Gln Lys Leu Ala Glu Gly Trp Lys Asn Gly 
    770                 775                 780                 


Phe Asn Leu Pro Arg Gly Leu Phe Thr Glu Lys Ile Lys Thr Trp Phe 
785                 790                 795                 800 


Asn Glu His Lys Thr Ile Val Asp Ile Ser Asp Cys Asp Ile Phe Lys 
                805                 810                 815     


Asn Arg Val Gly Gln Val Ala Arg Leu Ile Pro Val Phe Phe Asp Lys 
            820                 825                 830         


Lys Phe Lys Asp His Ser Gln Pro Phe Tyr Arg Tyr Asp Phe Asn Val 
        835                 840                 845             


Gly Asn Val Ser Lys Pro Thr Glu Ala Asn Tyr Leu Ser Lys Gly Lys 
    850                 855                 860                 


Arg Glu Glu Leu Phe Lys Ser Tyr Gln Asn Lys Phe Lys Asn Asn Ile 
865                 870                 875                 880 


Pro Ala Glu Lys Thr Lys Glu Tyr Arg Glu Tyr Lys Asn Phe Ser Leu 
                885                 890                 895     


Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys Asn Gln Asp Ile 
            900                 905                 910         


Leu Ile Trp Leu Met Cys Lys Asn Leu Phe Asp Glu Lys Ile Lys Pro 
        915                 920                 925             


Lys Lys Asp Ile Leu Glu Pro Arg Ile Ala Val Ser Tyr Ile Lys Leu 
    930                 935                 940                 


Asp Ser Leu Gln Thr Asn Thr Ser Thr Ala Gly Ser Leu Asn Ala Leu 
945                 950                 955                 960 


Ala Lys Val Val Pro Met Thr Leu Ala Ile His Ile Asp Ser Pro Lys 
                965                 970                 975     


Pro Lys Gly Lys Ala Gly Asn Asn Glu Lys Glu Asn Lys Glu Phe Thr 
            980                 985                 990         


Val Tyr Ile Lys Glu Glu Gly Thr  Lys Leu Leu Lys Trp  Gly Asn Phe 
        995                 1000                 1005             


Lys Thr  Leu Leu Ala Asp Arg  Arg Ile Lys Gly Leu  Phe Ser Tyr 
    1010                 1015                 1020             


Ile Glu  His Asp Asp Ile Asp  Leu Lys Gln His Pro  Leu Thr Lys 
    1025                 1030                 1035             


Arg Arg  Val Asp Leu Glu Leu  Asp Leu Tyr Gln Thr  Cys Arg Ile 
    1040                 1045                 1050             


Asp Ile  Phe Gln Gln Thr Leu  Gly Leu Glu Ala Gln  Leu Leu Asp 
    1055                 1060                 1065             


Lys Tyr  Ser Asp Leu Asn Thr  Asp Asn Phe Tyr Gln  Met Leu Ile 
    1070                 1075                 1080             


Gly Trp  Arg Lys Lys Glu Gly  Ile Pro Arg Asn Ile  Lys Glu Asp 
    1085                 1090                 1095             


Thr Asp  Phe Leu Lys Asp Val  Arg Asn Ala Phe Ser  His Asn Gln 
    1100                 1105                 1110             


Tyr Pro  Asp Ser Lys Lys Ile  Ala Phe Arg Arg Ile  Arg Lys Phe 
    1115                 1120                 1125             


Asn Pro  Lys Glu Leu Ile Leu  Glu Glu Glu Glu Gly  Leu Gly Ile 
    1130                 1135                 1140             


Ala Thr  Gln Met Tyr Lys Glu  Val Glu Lys Val Val  Asn Arg Ile 
    1145                 1150                 1155             


Lys Arg  Ile Glu Leu Phe Asp  
    1160                 1165 


<210>  1765
<211>  1121
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1765

Met Thr Lys Pro Glu Asn Tyr Asn Leu Ile Glu Thr Pro Trp Tyr Phe 
1               5                   10                  15      


Gly Ala Tyr Leu Asn Met Ala Arg His Asn Ile Tyr Leu Ile Ser Asn 
            20                  25                  30          


Glu Ile Ser Glu Lys Ile Asn Leu Asn Asn Met Leu Ser Ala Glu Glu 
        35                  40                  45              


His Ile Ser Asn Ser Phe Leu Thr Lys Gln Asp Phe Leu Asn Lys Asn 
    50                  55                  60                  


Asn Pro Arg Leu Ile Leu Ser Met Leu Ser Arg Phe Met Pro Ala Val 
65                  70                  75                  80  


Lys Ile Phe Ser Ser Asp Leu Leu His Lys Glu Leu Arg Glu Lys Ala 
                85                  90                  95      


Asp Thr Glu Gly Val Asp Ile Leu Gly Met Ala Thr Phe Leu Gln His 
            100                 105                 110         


Ser Phe Lys Glu Leu Asn Ala Phe Arg Asn Asp Tyr Ser His Tyr Tyr 
        115                 120                 125             


Ser Ser Lys Thr Gln Asp Lys Arg Lys Val Thr Val Asp Glu Asp Phe 
    130                 135                 140                 


Ala Ile Met Leu Arg Lys Gln Phe Asp Phe Ala Ile Ser Ile Ala Arg 
145                 150                 155                 160 


Lys Arg Phe Glu Gly Val Ile Pro Ala Lys Ser Phe Asp Phe Val Glu 
                165                 170                 175     


Asn Lys Ile Ala Gln Asp Leu Phe Ser Asp Ser Thr Thr Ile Thr Thr 
            180                 185                 190         


Arg Gly Phe Val Phe Phe Asn Cys Leu Phe Leu Asp Lys Glu Asn Ala 
        195                 200                 205             


Phe Gln Leu Phe Asn Lys Val Ser Gly Phe Lys Asp Thr Arg Thr Phe 
    210                 215                 220                 


Asp Phe Leu Ala Thr Arg Glu Val Phe Thr Val Phe Cys Val Lys Leu 
225                 230                 235                 240 


Pro His Asp Lys Phe Val Ser Glu Asp Pro Asn Gln Ala Leu Gln Leu 
                245                 250                 255     


Asp Ile Leu Asn Tyr Leu His Lys Ala Pro Lys Glu Leu Tyr Asn Ser 
            260                 265                 270         


Leu Thr Lys Glu Gly Lys Lys Ile Phe Gln Pro Asp Leu Ser Glu Leu 
        275                 280                 285             


Ala Lys Ser Asn Ile Ala Glu Asn Ser Thr Asn Asn Thr Ile Ala Glu 
    290                 295                 300                 


Phe Glu Tyr Asp Glu Tyr Ile Gln Ala Ile Ser Thr Lys Lys Arg Ser 
305                 310                 315                 320 


Asp Asp Arg Phe Ser Glu Phe Ala Leu Lys Tyr Leu Asp Gln Ser Asp 
                325                 330                 335     


Thr Phe Gln Phe Asp Phe His Ile Asn Leu Gly Lys Ala Ile Thr Lys 
            340                 345                 350         


Ser Tyr Glu Lys Ala Val Leu Gly Glu Lys Pro Asn Glu Asn Asn Arg 
        355                 360                 365             


Asn Ile Glu Lys Ser Ile Lys Thr Phe Gly Ala Leu Thr Ser Tyr Lys 
    370                 375                 380                 


Lys Tyr Val Glu Glu Asp Val Asn Glu Ile Lys Ser Leu Ile Thr Gln 
385                 390                 395                 400 


Glu Ser Glu Leu Lys Lys Leu Phe Asp Glu Lys Ala Pro Glu His Phe 
                405                 410                 415     


Ser Gln Tyr Ala Pro His Phe His Thr Gln Asn Asn Lys Ile Gly Leu 
            420                 425                 430         


Leu Ser Lys Gln Asn Lys Lys Tyr Phe Asn Lys Leu Tyr Arg Pro Ile 
        435                 440                 445             


Pro Pro Asp Ala Phe Leu Ser Ile His Glu Leu Pro Lys Val Val Leu 
    450                 455                 460                 


Leu Glu Ile Leu Asn Lys Gly Lys Ala Ser Glu Leu Ile Thr Ala Phe 
465                 470                 475                 480 


Leu Gln Lys Asn Asn Asp Val Val Leu Asn Arg Asp Phe Ile Asn Asn 
                485                 490                 495     


Val Lys Ser Asp Leu Asn Phe Thr Pro Leu Gln Arg Val Phe Phe Asp 
            500                 505                 510         


Lys Asn Leu Ser Ala Thr Lys Tyr Cys Ser Asn Ile Glu Ser Glu Ile 
        515                 520                 525             


Asp Lys Thr Lys Glu Glu Ile Asn Ser Cys Lys Phe Asp Asn Gln Lys 
    530                 535                 540                 


Arg Thr Leu Arg Leu Lys Leu Lys Ser Leu Ile Tyr Thr Lys Tyr Val 
545                 550                 555                 560 


His Glu Val Glu Ser Arg Lys Asn Lys Leu Asn Lys Val Leu Lys Asp 
                565                 570                 575     


His Gln Leu Ser Ala Asn Gln Ile Pro Gly Arg Val Ile Asp Tyr Trp 
            580                 585                 590         


Leu Asn Ile Thr Asp Val Ser Ile Glu Asn Ala Ile Lys Asn Arg Ile 
        595                 600                 605             


Ile Ala Glu Arg Lys Asp Cys Val Lys Arg Ile Lys Asp Leu Thr Asn 
    610                 615                 620                 


Gly Lys Ile Pro Lys Val Gly Glu Met Ala Thr Phe Leu Ala Arg Asp 
625                 630                 635                 640 


Ile Val Asn Leu Ile Ile Asn Glu Asn Val Lys Asn Lys Ile Thr Ser 
                645                 650                 655     


Phe Tyr Tyr Asp Leu Leu Gln Glu Cys Leu Ala Leu Tyr Ala Asn Pro 
            660                 665                 670         


Asp Lys Lys Gln Leu Phe Ile Asp Leu Cys Thr Lys Glu Leu Asn Leu 
        675                 680                 685             


Phe Asp Lys Asn Ile Gly His Pro Phe Leu Ala Asp Ile Asp Phe Asn 
    690                 695                 700                 


Lys Ile Ile Lys Thr Lys Asp Leu Tyr Arg Gln Tyr Leu Glu Phe Lys 
705                 710                 715                 720 


Gly Thr Lys Lys Arg Phe Glu Lys Glu Asp Asn Trp Ile Ile Asn Thr 
                725                 730                 735     


Phe Tyr Ser Ile Ser Lys Asp Glu Lys Thr Lys Lys Asn Ile Thr Glu 
            740                 745                 750         


Ile Lys Leu Pro Glu Ser Asn Ile Pro Leu Ser Tyr Leu Arg Leu Asn 
        755                 760                 765             


Arg Asp Lys Ser Asp Phe Asp Phe Trp Leu Asn Ser Val Ser Lys Gly 
    770                 775                 780                 


Asn Asp Lys Asn Pro Asn Pro Lys Pro Ile Asp Leu Pro Thr Asn Leu 
785                 790                 795                 800 


Phe Asp Lys Thr Leu Ile Ser Leu Leu Lys Glu Lys Val Lys Thr Asp 
                805                 810                 815     


Glu Asn Thr Lys Tyr Asn Tyr Ser Lys Leu Leu Ala Leu Trp Met Asn 
            820                 825                 830         


Glu Thr Gln His Tyr Tyr Asn Leu Lys Arg Glu Tyr Thr Ile Tyr Lys 
        835                 840                 845             


Asp Lys Pro Tyr Gln Ala Ile Val Gln Phe Asp Pro Asn Glu Lys Lys 
    850                 855                 860                 


Ser Phe Lys Glu Tyr Tyr Ala Ala Ser Leu Glu Glu Thr Phe Lys Lys 
865                 870                 875                 880 


Arg Lys Lys Glu Glu Lys Arg Ile Gln Glu Lys Gln Val Ala Thr Val 
                885                 890                 895     


Phe Lys Lys Ala Ile Glu Asn Asn Glu Lys Val Ile Arg Phe Tyr Gln 
            900                 905                 910         


Thr Lys Asp Arg Ile Thr Leu Leu Ile Leu Asn Glu Leu Ile Gly Glu 
        915                 920                 925             


Asp Leu Tyr Ile Ser Leu Asn Glu Leu Ser Pro Asp Ser Asp Lys Ser 
    930                 935                 940                 


Pro Leu Glu Ala Gln Ile Pro Leu Lys Glu Asn Ile Lys Gly Lys Ile 
945                 950                 955                 960 


Ile Thr Asp Thr Arg Lys Arg Lys Asp Phe Ser Ile Phe Arg Lys Leu 
                965                 970                 975     


Ala Ser Asp Arg Arg Leu Asn His Leu Phe Glu Tyr Tyr Asn Glu Glu 
            980                 985                 990         


Thr Ile Pro Tyr Glu Val Leu Arg  Lys Glu Leu Asn Asp  Tyr Asp Arg 
        995                 1000                 1005             


Tyr Lys  Glu Gln Val Phe Lys  Ala Ala Phe Asp Leu  Glu Lys Ala 
    1010                 1015                 1020             


Ile Ile  Asn Ala Ala Ser Glu  Met Glu Tyr Glu Gln  Ile Val Lys 
    1025                 1030                 1035             


Asp Gly  Thr Gln Glu Gly Pro  Asn Ile Gln His Lys  Ala Tyr Leu 
    1040                 1045                 1050             


Asn Trp  Leu Val Lys Tyr Glu  Ile Ile Asp Ser Lys  Glu Arg Glu 
    1055                 1060                 1065             


Phe Ile  Asn Asn Ile Arg Asn  Thr Phe Ser His Asn  Gln Tyr Pro 
    1070                 1075                 1080             


Lys Lys  Ala Ile Val Asp Asp  Phe Asn Ile Asp Phe  Gln Asn Ser 
    1085                 1090                 1095             


Thr Ile  Ser Ser Lys Ile Val  Asp Thr Tyr Leu Glu  Lys Val Asn 
    1100                 1105                 1110             


Lys Ile  Ile Lys Thr Lys Leu  Ile 
    1115                 1120     


<210>  1766
<211>  1147
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1766

Met Glu Ile Ala Thr Gln Gln Ser Glu Thr Gln Lys Lys Lys Arg Ser 
1               5                   10                  15      


Leu Asp Gln Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg 
            20                  25                  30          


His Asn Val Phe Leu Ile Val Asn His Leu Thr Asp Thr Phe Lys Glu 
        35                  40                  45              


Leu Asn Phe Lys Lys Leu Ala Asn Glu Glu Asp Ile Trp Lys Val Asp 
    50                  55                  60                  


Asn Ser Ser Asn Ile Leu Leu Asn Val Phe Asp Val Thr Gln Ser Lys 
65                  70                  75                  80  


Tyr Glu Asp Phe Arg Pro Arg Ile Phe His Tyr Leu Ile Lys Arg His 
                85                  90                  95      


His Leu Pro Leu Val Lys Ile Phe Asn Thr Glu Tyr Leu Gly Glu Asn 
            100                 105                 110         


Ile Leu Gln Asp Lys Ser Ile Asp Tyr Glu Arg Leu His Gln Phe Leu 
        115                 120                 125             


Cys Leu Ser Phe Lys Glu Leu Thr Glu Phe Arg Asn Ser Tyr Ser His 
    130                 135                 140                 


Ser Ile Ala Ile Asp Glu Asn Gly Asn Lys Val Gly Arg Lys Thr Thr 
145                 150                 155                 160 


Leu Ala Asn Asp Leu Val Pro Glu Val Asn Leu Leu Phe Lys Tyr Ala 
                165                 170                 175     


Pro Lys Tyr Ser Phe Leu Arg Asn His Gln Thr Leu Asn Glu Gly Asp 
            180                 185                 190         


Phe Gln His Leu Asp Asn Tyr Gln Leu Phe Ile Ala Asp Asn Gln Leu 
        195                 200                 205             


Thr His Gln Gly Arg Phe Phe Phe Ile Asn Leu Phe Leu Glu Arg Ser 
    210                 215                 220                 


Tyr Gly Ile Lys Phe Leu Lys Arg Phe Arg Gly Phe Lys Asn Glu Asn 
225                 230                 235                 240 


Thr Pro Pro Phe Lys Ala Thr Ile Gln Ser Phe Thr Thr Tyr Cys Leu 
                245                 250                 255     


Lys Val Pro Asp Ile Arg Leu Gly Asn Glu Asn Pro Lys Gln Ser Leu 
            260                 265                 270         


Leu Leu Asp Met Leu Thr Glu Leu Asn Lys Cys Pro Lys Glu Leu Phe 
        275                 280                 285             


Asn His Leu Thr Glu Asp Asp Lys Lys Glu Phe Glu Pro Asn Leu Asp 
    290                 295                 300                 


Glu Thr Ser Ser Thr Asn Val Leu Leu Asn Ser Thr Asn Tyr Glu Phe 
305                 310                 315                 320 


Phe Asp Thr Asp Glu Val Glu Glu Ala Ile Arg Glu Leu Thr Ala Gln 
                325                 330                 335     


Lys Arg His Ser Asp Arg Phe Pro Tyr Leu Ala Leu Arg Phe Leu Asp 
            340                 345                 350         


Glu Thr Met Ala Phe Ser Gln Leu Arg Phe Gln Leu Ser Leu Gly Lys 
        355                 360                 365             


Ile Ile Ile Lys Lys Pro Tyr Gln Lys Thr Ile Leu Gly Gln Pro Asn 
    370                 375                 380                 


Asp Arg Ile Ile Thr Lys Lys Leu Asn Val Phe Gly Arg Ile Ser Asp 
385                 390                 395                 400 


Phe Leu Asn Arg Glu Lys Glu Ile Ile Arg Ala Leu Ser Asn Asp Gln 
                405                 410                 415     


Asn Val Asp Phe Leu Glu Phe Glu Gln Phe Phe Pro His Tyr Asn Ile 
            420                 425                 430         


Asn Asn Asn Lys Ile Ala Phe Tyr Phe Leu Asn Asp Ser Asp Leu Thr 
        435                 440                 445             


Glu Glu Asn Leu Glu Ser Arg Leu Arg Asp Gln Glu Asn Arg Gln Pro 
    450                 455                 460                 


Thr Gly Phe Leu Ser Ile His Asp Leu Pro Lys Leu Val Leu Leu His 
465                 470                 475                 480 


Leu Leu Ala Pro Ser Glu Val Gln Lys Thr Leu Gln Arg Phe Ile Asn 
                485                 490                 495     


Asp Asn Asn Pro Ala Phe Phe Asp Leu Glu Leu Leu Ala Asn Ile Lys 
            500                 505                 510         


Ser Lys Val Val Tyr Glu Pro Ser Thr Phe Thr Lys Arg Ser Glu His 
        515                 520                 525             


Gln Tyr Arg Asp Ala Asp Lys Gln Glu Glu Glu Thr Glu Lys Gln Gln 
    530                 535                 540                 


Glu Tyr Gln Thr Leu Leu Asn Gln Arg Lys Arg Leu Leu Glu Gln His 
545                 550                 555                 560 


Leu Pro Lys Gly Val Lys Ile Asn Gln Ile Pro Glu Lys Val Leu Asp 
                565                 570                 575     


Phe Leu Met Asn Ile Ser Glu Pro Asn Glu Asn Lys Val Ile His Gln 
            580                 585                 590         


Lys Ile Lys Ser Ile Lys Asp Glu Ala Lys Thr Leu Leu Gln Arg Val 
        595                 600                 605             


Lys Asn Lys Gln Ala Ala Asn Glu Ile Pro Lys Leu Gly Glu Leu Ala 
    610                 615                 620                 


Thr Phe Leu Thr Arg Asp Ile Ile Asn Met Val Val Ser Glu Glu Leu 
625                 630                 635                 640 


Lys Lys Lys Ile Thr Ser Pro Tyr Ser Asn Lys Leu Gln Asn Lys Ile 
                645                 650                 655     


Ala Phe Phe Ser Leu Ser Lys Gln Glu Ile Ile Ser Leu Leu Ser Glu 
            660                 665                 670         


Leu Gln Leu Leu Asn Asn Glu Lys Gly His Val Phe Leu Ser Ser Arg 
        675                 680                 685             


Leu Ile Leu Glu Ser Asn Gly Leu Leu Ser Phe Tyr Lys Ser Tyr Leu 
    690                 695                 700                 


Glu Ala Lys Ile Ala Trp Ile Asp Lys Asn Leu Phe Leu Lys Gly Lys 
705                 710                 715                 720 


Lys Gly Gly Tyr Ile Ile Pro Glu Asn Lys Pro Val Pro Lys Thr Leu 
                725                 730                 735     


Gln Lys Ile Lys Gln Glu Val Ser Gln Phe Asp Phe Thr Gln Trp Leu 
            740                 745                 750         


Gln Asn Lys Ala Ala Met Pro Ile Asp Val Pro Asn Thr Ile Phe Asp 
        755                 760                 765             


Val Ser Leu Glu Asn Leu Leu Lys Thr Asn Leu Lys Lys Arg Gly Ile 
    770                 775                 780                 


Thr Val Lys Asp Thr Asp Lys Phe Ser Val Leu Leu Asn Lys Tyr Leu 
785                 790                 795                 800 


Asp Lys Asp Thr Gln Pro Phe Tyr Lys Tyr Gly Arg Val Tyr Lys Ile 
                805                 810                 815     


Gln Asp Glu Glu Glu Ser Val Gln Val Val Gly Lys Met Ser Lys Thr 
            820                 825                 830         


Leu Lys Lys Gln Tyr Gly Lys Phe Val Glu Glu Asn Glu Lys Val Ile 
        835                 840                 845             


Arg Phe Tyr Gln Ser Lys Asp Arg Val Ile Lys Leu Met Cys Asn Ala 
    850                 855                 860                 


Leu Leu Gln Ala Glu Asn Lys Thr Ala Leu Thr Asp Ser Phe Lys Leu 
865                 870                 875                 880 


Ala His Thr His Pro Asn Ser Lys Gln Asn Pro Leu Asp Thr Pro Met 
                885                 890                 895     


Arg Phe Glu Gln Lys Leu Phe Ser Asn Asp Lys Glu Thr Lys Val Leu 
            900                 905                 910         


Cys Thr Ile Tyr Ala Gln Asp Thr Glu Asn Gln Lys Asn Glu Ile Leu 
        915                 920                 925             


Ala Trp Asn Ser Leu Ser Glu Asp Asp Lys Lys Tyr Trp Leu Thr Leu 
    930                 935                 940                 


Thr Thr Lys Glu Ala Gln Lys Glu Trp Leu Ser Gly Lys Pro Glu Thr 
945                 950                 955                 960 


Glu Gln Glu Val Tyr His Gly Gln Lys Gly Tyr Gln Trp Thr Ile Lys 
                965                 970                 975     


Glu Val Gly Lys Phe Lys Arg Phe Val Lys Asp Arg Arg Ile Pro Ala 
            980                 985                 990         


Leu Val Asn Tyr Phe Glu Thr Thr  Lys Leu Pro Phe Ser  Leu Leu Glu 
        995                 1000                 1005             


Tyr Gln  Leu Lys Glu Tyr Asp  Arg Val Arg Glu Gln  Ile Phe Asp 
    1010                 1015                 1020             


Gly Val  Phe Lys Leu Glu Glu  Ala Ile Ser Gln Lys  Asp Leu Ala 
    1025                 1030                 1035             


Gly Ile  Trp Ala Leu Glu Gln  Glu Ala Arg Gly Arg  Lys Asn Tyr 
    1040                 1045                 1050             


His Gln  Val Gln Phe Asn Ile  Phe Glu Lys Tyr Leu  Gln Asn Thr 
    1055                 1060                 1065             


Leu Pro  Ser Tyr Asp Pro Ala  Ile Gly Val Ile Arg  Asn Lys Phe 
    1070                 1075                 1080             


Ser His  Asn Glu Phe Pro Asp  Leu Ile Gly Gln Gly  Ile Glu Lys 
    1085                 1090                 1095             


Ile Ser  Gln Ala Gln Ile Asp  Asp Tyr Gln Arg Asn  Lys His Leu 
    1100                 1105                 1110             


Lys Asp  Tyr Leu Ala His Ala  Gly Ile Ser Ile Ala  Gln Gln Ile 
    1115                 1120                 1125             


Leu Ala  Ile Phe Glu Gln Lys  Ile Asn Asp Thr Leu  Thr Gln Leu 
    1130                 1135                 1140             


Thr Thr  His Gly 
    1145         


<210>  1767
<211>  1133
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1767

Met Lys Glu Asn Asn Thr Glu Gln Arg Ile His Tyr Thr Leu Glu Ala 
1               5                   10                  15      


Thr Pro Trp Tyr Phe Gly Ala Tyr Leu Asn Ile Ala Arg His Asn Ile 
            20                  25                  30          


Tyr Leu Ile Ser Asn Glu Ile Gly Arg Lys Leu Lys Pro Glu Arg Lys 
        35                  40                  45              


Leu Cys Lys Glu Glu Gln Ile Ala Asp Ser Phe Leu Val Lys Lys Asp 
    50                  55                  60                  


Phe Ile Glu Lys Gln Asn Val Asn Leu Ile Tyr Val Asn Leu Val Arg 
65                  70                  75                  80  


Phe Leu Pro Leu Ala Lys Met Phe Ser Thr Asp Ile Leu Asp Asp Gln 
                85                  90                  95      


Leu Pro Glu Lys Glu Leu Asn Ile Ser Glu Trp Thr Ser Ile Leu Lys 
            100                 105                 110         


Val Leu Phe Ser Glu Ile Asn Ser Phe Arg Asn Asn Tyr Ser His Tyr 
        115                 120                 125             


Tyr Ser Ser Glu Thr Leu Ser Glu Arg Lys Val Lys Val His Thr Asp 
    130                 135                 140                 


Phe Ala Asp His Ile Lys Asp Ile Phe Ser Leu Ala Val Leu Ser Ala 
145                 150                 155                 160 


Glu Gln Arg Phe Arg Gly Val Leu Pro Gly Ser Ser Phe Arg Phe Val 
                165                 170                 175     


Glu Lys Glu Ile Leu Pro Gln Leu Phe Asn Asp Arg Cys Glu Ile Ser 
            180                 185                 190         


Ala Arg Gly Leu Ile Phe Phe Ile Ser Leu Phe Leu Asp Lys Glu Asn 
        195                 200                 205             


Ala Phe His Leu Phe Asn Lys Val Ser Gly Phe Lys Asn Thr Thr Thr 
    210                 215                 220                 


Phe Asp Phe Leu Ala Thr Arg Glu Val Phe Ser Val Leu Cys Ile Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Ile Ser Glu Asn Pro Asp Gln Ala Gln Gln 
                245                 250                 255     


Leu Asp Ile Leu Asn Tyr Leu Asn Arg Ala Pro Lys Glu Leu Phe Gln 
            260                 265                 270         


Ala Leu Ser Glu Glu Gly Arg Lys Gln Phe Leu Pro Asp Leu Ser Glu 
        275                 280                 285             


Leu Val Lys Ser Ser Ile Ile Glu Asn Ser Met Ser Asp Asp Val Glu 
    290                 295                 300                 


Glu Tyr Arg Tyr Glu Glu Tyr Ile Gln Ala Ile Ser Ser Lys Lys Arg 
305                 310                 315                 320 


Ser Lys Asp Arg Phe Pro Glu Phe Ala Leu Lys Tyr Leu Asp Gln Ser 
                325                 330                 335     


Asp Ser Phe Lys Phe Ser Phe His Ile Leu Leu Gly Lys Ser Lys Ile 
            340                 345                 350         


Arg Gly Tyr Lys Lys Pro Leu Leu Gly Ala Leu Pro Glu Glu Asn Asn 
        355                 360                 365             


Arg Ser Ile Ile Arg Asp Met Thr Thr Phe Gly Gln Leu Lys Thr Tyr 
    370                 375                 380                 


Leu Gly Glu Asp Ala Arg Asp Arg Ile Val Leu Glu Arg Met Phe Cys 
385                 390                 395                 400 


Glu Leu Phe Lys Gly Asp Asp Ile Glu Tyr Phe Thr Gln Tyr Ala Pro 
                405                 410                 415     


Phe Tyr His Ile Ala Asn Asn Lys Ile Gly Ile Leu Ser His Lys Asn 
            420                 425                 430         


Arg Lys Tyr Ser Ser Met Leu Tyr Arg Pro Leu Gln Ala Asp Ala Phe 
        435                 440                 445             


Leu Ser Ile His Glu Leu Pro Lys Val Ala Leu Leu Glu Val Leu Asp 
    450                 455                 460                 


Lys Gly Ser Ala Ser Ala Ile Ile Asp Ala Phe Leu Glu Lys Asn Ile 
465                 470                 475                 480 


Arg His Ile Leu Asn Glu Thr Phe Ile Arg Asp Ile Lys Arg Gln Leu 
                485                 490                 495     


Ser Phe Asp Gly Ala Leu Tyr Arg Phe Cys Phe Asp Glu Lys Leu Ser 
            500                 505                 510         


Val Val Gln Pro Ala Asp Leu Asp Ala Glu Ile Glu Glu Val Glu Met 
        515                 520                 525             


Arg Leu Ala Val Thr Arg Asp Ala Asn Glu Leu Lys Lys Leu Asn Val 
    530                 535                 540                 


Lys Arg Arg Ser Leu Arg Tyr Ala Lys Tyr Val Arg Glu Val Asn Lys 
545                 550                 555                 560 


Arg Lys Lys Val Val Asn Gln Leu Leu Ala Glu Tyr Asp Leu Asn Val 
                565                 570                 575     


Arg Gln Ile Pro Ala Arg Ile Leu Asp Tyr Trp Leu Asp Ile Arg Ile 
            580                 585                 590         


Val Arg Lys Glu Thr Thr Phe Gln Asn Arg Ile Lys Ala Glu Arg Lys 
        595                 600                 605             


Val Cys Lys Lys Arg Leu Lys Asp Leu Gly Lys Gly Lys Gly Pro Arg 
    610                 615                 620                 


Ile Gly Glu Met Ala Ser Tyr Leu Ala Arg Asp Ile Val Asp Leu Val 
625                 630                 635                 640 


Leu Asp Arg Gly Ile Lys Asp Lys Ile Thr Ser Phe Tyr Tyr Asp Ile 
                645                 650                 655     


Leu Gln Ser Ser Leu Ala Leu Tyr Ala Asp Pro Asp Lys Lys Arg Leu 
            660                 665                 670         


Phe Leu Asp Val Cys Ser Arg Glu Leu Gly Leu Phe Asp Lys Lys Lys 
        675                 680                 685             


Gly His Pro Phe Leu Gly Asn Ile Asn Phe Asp Arg Ile Arg Lys Ile 
    690                 695                 700                 


Lys Asp Leu Tyr Lys Ile Tyr Leu Glu Phe Lys Gly Val Lys Glu Arg 
705                 710                 715                 720 


Thr His Gly Ser Asn Lys Tyr Gly Lys His Arg Thr Lys Ala Ile Gln 
                725                 730                 735     


Asp Asn Trp Leu Tyr Asn Thr Phe Tyr Thr Ile Gln Glu Asn Lys Lys 
            740                 745                 750         


Thr Gly Lys Asp Glu Thr Val Ile Lys Leu Pro Glu Asp Ser Ser Leu 
        755                 760                 765             


Val Pro Val Thr Tyr Leu Arg Phe Asn Glu Asp Arg Ser Asp Leu Asp 
    770                 775                 780                 


Thr Trp Leu Ser Thr Val Val Gln Gly Ser Glu His Asn Pro Asn Pro 
785                 790                 795                 800 


Lys Ala Val Asp Leu Pro Thr Asn Leu Phe Asp Glu Gln Leu Val Met 
                805                 810                 815     


Leu Leu Lys Glu Lys Val Gly Ile Lys Glu Asp Ser Gly Lys Lys Tyr 
            820                 825                 830         


Asn Phe Ser Lys Leu Leu Ser Leu Leu Arg Asn Asp Thr Gln Pro Phe 
        835                 840                 845             


Tyr Asn Asp Lys Arg Glu Tyr Ile Leu Phe Lys Asp Thr Pro Tyr Glu 
    850                 855                 860                 


Val Arg Val Ala Phe Asp Pro Leu Ser Ser Arg Lys Phe Ser Glu His 
865                 870                 875                 880 


Tyr Gln Glu Ala Met Asn Gln Ser Phe Arg Ile Arg Lys Lys Met Asp 
                885                 890                 895     


Lys Arg Ile Gln Leu Asn Gln Val Arg Arg Leu Phe Lys Lys Ala Ile 
            900                 905                 910         


Asp Glu Asn Glu Lys Gln Ile Arg Phe Tyr Gln Ala Lys Asp Arg Ile 
        915                 920                 925             


Ile Leu Leu Met Leu Lys Asp Met Ile Gly Arg Asp Leu Asp Phe Ser 
    930                 935                 940                 


Leu Asn Ala Val Ser Pro Gln Ala Pro Gln Asn Pro Leu Asn Thr Pro 
945                 950                 955                 960 


Val Asp Leu Ser Glu Ile Ile His Ser Lys Thr Ile Thr His Thr Cys 
                965                 970                 975     


Lys Arg Lys Asp Phe Ser Ile Phe Arg Lys Leu Leu Ser Asp Arg Arg 
            980                 985                 990         


Leu Ser Gly Leu Phe Gln Tyr Phe  Asp Ser Asp Ile Ile  Pro Tyr Glu 
        995                 1000                 1005             


Ile Leu  Arg Lys Glu Leu Ser  Asp Tyr Glu Arg Tyr  Lys Glu Gln 
    1010                 1015                 1020             


Val Phe  Lys Thr Val Phe Glu  Leu Glu Lys Gln Ile  Ile Ala Val 
    1025                 1030                 1035             


Met Ser  Glu Glu Glu Leu Asn  Asn Leu Lys Ala Thr  Ser Gly Thr 
    1040                 1045                 1050             


Asn Ile  Gln His Lys Pro Tyr  Leu Asp Trp Leu Ala  Asp Tyr Gly 
    1055                 1060                 1065             


Ile Leu  Thr Arg Glu Glu Arg  Ala Phe Cys Ile Glu  Val Arg Asn 
    1070                 1075                 1080             


Lys Leu  Ser His Asn Gln Phe  Pro Asp Lys Ala Val  Met Asp Thr 
    1085                 1090                 1095             


Phe Val  Gly Gln Pro Asp Ser  Thr Gln Thr Asn Ile  Lys Gln Ile 
    1100                 1105                 1110             


Val Ser  Ala Tyr Ile Thr Ile  Val Asn Thr Leu Ile  Ala Thr Lys 
    1115                 1120                 1125             


Leu Leu  Ala Lys Arg 
    1130             


<210>  1768
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1768

Met Gly Ala Ile Lys Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Gly Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1769
<211>  1212
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1769

Met Val Lys Pro Ile Asn Pro Phe Asp Leu Phe Thr Gly Gly Lys Gln 
1               5                   10                  15      


Pro Glu Leu Ala Ile Ala Tyr Asn Leu Ala His Asp Asn Ile Thr Lys 
            20                  25                  30          


Tyr Ile Asn Thr Leu Leu Thr Phe Asn Lys Pro Asp Tyr Lys Pro Leu 
        35                  40                  45              


Glu His Ile Asn Asp Leu Pro Asp Glu Val Phe Val Tyr Leu Arg His 
    50                  55                  60                  


Tyr Leu Trp Lys Gly Asn Asp Glu Asn Lys Asn Thr Ser Gly Tyr Glu 
65                  70                  75                  80  


Leu Asp Pro Gln Glu Lys Ser Ile Ile Lys Lys Leu Leu Thr Lys Leu 
                85                  90                  95      


Asp Glu Leu Arg Asn Phe Tyr Ser His Ile Trp His Asp Asn Tyr Met 
            100                 105                 110         


Met Ala Phe Asp Lys Glu Leu Tyr Ser Phe Ile Leu Asn Lys His Asp 
        115                 120                 125             


Val Ala Cys Ser Lys Leu Glu Thr Lys Ala Ala Asp Arg Glu Leu Tyr 
    130                 135                 140                 


Phe Lys Gln Ile Glu Lys Tyr Pro Leu Phe Lys Asp Tyr Lys Tyr Ile 
145                 150                 155                 160 


Thr Gln Asp Gly Arg Val Phe Leu Leu Ser Phe Phe Leu Asn Lys Gly 
                165                 170                 175     


Glu Met Gln Ser Leu Leu Gln Arg Leu Lys Gly Tyr Lys Arg Thr Asn 
            180                 185                 190         


Glu Pro Gln Tyr His Phe Lys His Lys Leu Tyr Thr His Tyr Cys His 
        195                 200                 205             


Arg Glu Gly Ser Ser Trp Asp Ser Thr Gly Ile Glu Asn Lys Glu Leu 
    210                 215                 220                 


Glu Lys Arg Thr Asn Ser Glu Gln Thr Arg Ile Leu Ser Gly Arg Gln 
225                 230                 235                 240 


Ala Tyr Arg Ile Phe Asn Tyr Leu Lys Asp Ile Pro Ala Phe Thr Leu 
                245                 250                 255     


Asp Glu Ala Leu Pro Leu Ile Leu Gln Ser Gly Thr Trp Val His Asn 
            260                 265                 270         


Met Asp Thr Leu Leu Val Phe Ile Lys Glu Lys Asn Ile Leu Pro Gly 
        275                 280                 285             


Phe Asn Phe Tyr Lys Lys Phe Glu Val Pro Glu Asn Asp Glu Thr Leu 
    290                 295                 300                 


Asp Ala Lys Glu Leu Asn Glu Ala Asn Lys Leu Leu Glu Lys Lys Glu 
305                 310                 315                 320 


Arg Glu Gly Tyr Arg Tyr Phe Thr Tyr Ser Gly Asp Asn Asn Cys Glu 
                325                 330                 335     


Phe Glu Ile Ser Tyr Ala Asn Leu Lys His Ile Val Thr Asp Leu Phe 
            340                 345                 350         


Leu Asp Val Asn Thr Gly Glu Asn Asn Asn Gln Ser Gln Thr His Phe 
        355                 360                 365             


Leu Gly Val Leu Lys Asp Cys Ile Asp Thr Arg Lys Phe Ile Phe Asp 
    370                 375                 380                 


Ser Leu Lys Ala Gly Gly Asn Lys Pro Leu His Thr Glu Asn Phe Lys 
385                 390                 395                 400 


Leu Glu Lys Arg Tyr Ser Ser Ile Tyr Ile Asn Tyr Lys Glu Tyr Glu 
                405                 410                 415     


Asp Ala Ile Gln Glu Arg Tyr Tyr Thr Gly Asp Glu Trp Arg His Ile 
            420                 425                 430         


Pro Ile Ser Pro Thr Pro Lys Val Glu Lys Leu Leu Ile Glu Trp His 
        435                 440                 445             


Ala Glu Phe Met Arg Gly Thr Asn Asp Lys Pro Ser Lys Asn Glu Val 
    450                 455                 460                 


Ala Lys Arg Lys Lys Leu Leu Asn Leu Ile Arg Pro Arg Asn Glu Pro 
465                 470                 475                 480 


Phe Asp Thr Ser Ala Tyr Glu Gly Leu Leu Arg Thr Gly Lys Lys Lys 
                485                 490                 495     


Lys Leu Pro Glu Val Thr Asp Pro Ala Pro Leu Leu Phe His Leu Ser 
            500                 505                 510         


Tyr Tyr Tyr Arg Glu Leu Asp Thr Lys Lys Arg Ser Glu Asp Arg Phe 
        515                 520                 525             


Leu Ala Trp Gly Val His Tyr Leu Ile Asp Met Gly Leu Val Pro Asp 
    530                 535                 540                 


Trp His Phe Glu Leu Glu Gln Leu Lys Tyr Glu Gln Lys Leu Gly Asp 
545                 550                 555                 560 


Pro Glu Ser Pro Tyr Lys Phe Lys Lys Val Thr Thr Trp Ala Lys Gly 
                565                 570                 575     


Ile Thr Asp Asn Phe Arg Leu Tyr Ile Thr Asp His His Val Asn Val 
            580                 585                 590         


Gly Ile Gln Lys Asp Gly Val Ile Tyr Arg Leu Arg Ile Gly Glu Lys 
        595                 600                 605             


Thr Ile Lys Tyr Leu Leu Phe Trp His Phe Lys Glu Lys Asn Lys Gly 
    610                 615                 620                 


Asp Lys Ser Ile Asn Gly Phe Leu Val Glu Val Cys Lys Asp Leu Ala 
625                 630                 635                 640 


Ala Ile Tyr Thr Asn Lys Ala Glu Lys Ile Ser Val Ser Ala Leu His 
                645                 650                 655     


Leu Leu Glu Asn Phe Ala Leu Pro Glu Leu Leu Tyr Lys Thr Lys Val 
            660                 665                 670         


Ala Glu Glu Ser Glu Lys Gly Arg Lys Ser Ile Leu Tyr Lys Glu Gln 
        675                 680                 685             


Val Leu Lys Phe Phe Thr Arg Lys Lys Asp Trp Val Asp Leu Gln Leu 
    690                 695                 700                 


Lys Asn Leu Arg Thr Leu Ser Arg Asn Glu Lys Asn Ala Ile Leu Leu 
705                 710                 715                 720 


Asp Ala Tyr Arg Leu Phe Asn Phe Ser Glu Thr Glu Gly Gln Lys Phe 
                725                 730                 735     


Leu Arg Lys Asn Glu Tyr Glu Gln Met Ser Val Cys His Phe Met Leu 
            740                 745                 750         


Asn Gln Glu Lys Phe Lys Val Lys Gly Leu Ile Glu Arg Thr Phe Lys 
        755                 760                 765             


Leu Lys Arg Arg Leu Pro Ala Glu Ile Ile Asn Ile Ile Tyr Ser Val 
    770                 775                 780                 


Val Glu Thr Asp Gly Glu Asn Leu Asp Asn Leu Leu Val Lys Ile Leu 
785                 790                 795                 800 


Arg Asn Arg Lys Ile Phe Leu Lys Gln Lys Val Asp Leu Leu Asn Asn 
                805                 810                 815     


Pro Gly Ile Lys Asn Lys Val Ile Lys Asn Asp Ile Val Asp Phe Phe 
            820                 825                 830         


Asp Ile Tyr Ile Asp Asp Ala Asn Leu Ser Ala Glu Glu Leu Ala Ile 
        835                 840                 845             


Arg Asn Asn Val Arg His Lys Thr Leu Glu Thr Leu Pro Phe Ser Val 
    850                 855                 860                 


His Pro Ala Leu Ala Leu Lys Tyr Phe Tyr Pro Gln Gln Phe Ala Ala 
865                 870                 875                 880 


Gln Gly Phe Arg Lys Glu Gly Gly Asn Tyr Ile Asn Val Phe Tyr Glu 
                885                 890                 895     


Leu Arg Lys Gln Ser Thr Arg Leu Ala Gly Ile Leu Pro Leu Gly Asn 
            900                 905                 910         


Phe Arg Glu Lys Glu Thr Ser Lys Ile Phe Asp Asn Tyr Thr Gln Leu 
        915                 920                 925             


Phe Ser Asp Asp Lys Leu Leu Lys Asn His Ile Lys Lys Trp Thr Gly 
    930                 935                 940                 


Glu Ile Asn Asp Ile Lys Val Lys Asp Ile Leu Leu Leu Leu Val Ala 
945                 950                 955                 960 


Glu Asp Tyr Leu Lys Lys Tyr Asp Gly Lys Thr Ala Glu Glu Phe Thr 
                965                 970                 975     


Lys Ile Arg Gly Leu Asn Lys Asn Lys Leu Asp Glu Leu Phe Ala Ser 
            980                 985                 990         


Glu Val Thr Val Thr Pro Asn Ile  Gln Ala Val Arg Ser  Glu Leu Asp 
        995                 1000                 1005             


Glu Glu  His Lys Asn Ile Ile  Pro Thr Ile Ile Tyr  Phe Ser Leu 
    1010                 1015                 1020             


His Met  His Gln Leu Asp Asp  Tyr Phe Phe Arg Ser  Gln Lys Asp 
    1025                 1030                 1035             


Asn Gln  Ile Lys Leu Ala Met  Phe Tyr Ile Asn Trp  Arg His Glu 
    1040                 1045                 1050             


Glu Leu  Gln Ala Tyr Lys Asp  His Asn Gly Ile Val  Glu Lys Ile 
    1055                 1060                 1065             


Thr Ala  Trp Pro Asp Gly Thr  Lys Gln Lys Pro Leu  Thr Met Gly 
    1070                 1075                 1080             


Asn Leu  Val Glu Ala Arg Arg  Val Asn Ala Gly His  Ala Ala Glu 
    1085                 1090                 1095             


Leu Val  Asn Tyr Ile Phe Asp  Tyr Glu Arg Gly Ile  Ile Asn Asn 
    1100                 1105                 1110             


Tyr Ala  Lys Lys Ala Pro Asn  Lys Gln Pro Gln Gln  Val Leu Gln 
    1115                 1120                 1125             


Glu Tyr  Ser Asn Ser Asn Leu  Asn Gly Lys Tyr Ile  Asp Phe Asp 
    1130                 1135                 1140             


Thr Val  Leu Gln Trp Asp Asn  Val Asn Glu Ala Asp  Ile Lys Ser 
    1145                 1150                 1155             


Asp Ile  Lys Thr Met Arg Val  Lys Cys Leu His Thr  Leu Ile Pro 
    1160                 1165                 1170             


Ile Asn  Gly Ser His Arg Gln  Lys Thr Leu Pro Gly  Thr Ala Leu 
    1175                 1180                 1185             


Ala Glu  Ala Leu His Ile Tyr  Lys Trp Leu Gly Asn  Asp Arg Thr 
    1190                 1195                 1200             


Ala Pro  Asn Ile Tyr Glu Gln  Glu Glu 
    1205                 1210         


<210>  1770
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1770

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Thr 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1771
<211>  1000
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1771

Met Glu Glu Ala Asn Arg Tyr Ile Tyr Gly Ala Tyr Phe Asn Met Ala 
1               5                   10                  15      


Arg Asp Asn Phe Leu Asn Thr Ile Lys Leu Leu Ala Asp Lys Met Lys 
            20                  25                  30          


Leu Gly Ala Ile Ser Gly Phe Gly Lys Asp Gly Asn Glu Val Asn Asp 
        35                  40                  45              


Ile Asn Lys Leu Phe Gly Asp Lys Asn Thr Tyr Ala Asn Ile Glu Asn 
    50                  55                  60                  


Val Val Glu Phe Tyr Phe Pro Trp Ile Lys Ala Leu Glu Gly Arg Phe 
65                  70                  75                  80  


Ser Leu Asp Lys Gly Asp Arg Asn Leu Asn Asp Met Lys Met Phe Tyr 
                85                  90                  95      


Lys Ser Val Leu Thr Ala Phe Phe Thr Ala Val Asp Ser Leu Arg Asn 
            100                 105                 110         


Lys Tyr Thr His Tyr Ser His Lys Asp Leu Asn Ile Arg Glu Ile Lys 
        115                 120                 125             


Ile Glu Cys Thr Leu Gly Gly Lys Asp Tyr Cys Ile Gly Leu Leu Asn 
    130                 135                 140                 


Ala Leu Asp Cys Ile Tyr Asp Ser Ala Val Asn Leu Leu Lys Leu Arg 
145                 150                 155                 160 


Phe Met Ala Gly Glu Asp Glu Val Ala His Leu Arg Arg Cys Lys Ala 
                165                 170                 175     


Val Asn Lys Lys Val Val Val Arg Thr Glu Lys Asp Gly Phe Tyr Tyr 
            180                 185                 190         


Arg Leu Ser Asp Asn Gly Gly Val Thr Glu Lys Gly Val Ile Phe Ile 
        195                 200                 205             


Ala Ser Met Phe Leu Asn Arg Lys Tyr Gly Phe Leu Phe Leu Lys Gln 
    210                 215                 220                 


Leu Glu Gly Phe Lys Arg Ser Asp Glu Lys Arg Tyr Arg Leu Thr Leu 
225                 230                 235                 240 


Glu Ala Phe Leu Ala Phe Ser Asn Ile Lys Pro Val Asp Arg Leu Lys 
                245                 250                 255     


Ser Asp Lys Leu Asp Arg Ala Ser Leu Gly Leu Asp Met Leu Asn Glu 
            260                 265                 270         


Leu Thr Lys Ile Pro Lys Glu Leu Ser Glu Thr Leu Ser Val Asp Cys 
        275                 280                 285             


Leu Tyr Lys Tyr Leu Ala Ser Asp Gly Glu Asp Asp Leu Arg Ser Arg 
    290                 295                 300                 


Ile Arg Tyr Gln Asp Arg Phe Val Pro Leu Ala Leu Glu Phe Ile Ser 
305                 310                 315                 320 


Gln Ser Asp Glu Phe Asn Asp Phe Arg Phe Tyr Thr Tyr Val Gly Asn 
                325                 330                 335     


Tyr Val Tyr Lys Gly Tyr Ile Lys Arg Leu Ile Asp Gly Thr Asp Lys 
            340                 345                 350         


Glu Arg Tyr Leu Ser Asp Arg Leu Cys Gly Phe Tyr Lys Ser Val Asn 
        355                 360                 365             


Asp Ala Ser Ser Asp Ala Ile Ala Gln Lys Tyr Gly Val Glu Ile Lys 
    370                 375                 380                 


Asp Ser Asn Glu Pro Asp Tyr Met Leu Pro Asp Ser Phe Arg Pro His 
385                 390                 395                 400 


Val Leu Arg Ala Thr Pro His Phe Val Ile Asn Asn Asn Asn Ile Gly 
                405                 410                 415     


Ile Lys Ile Cys Gly Asn Asp Cys Leu Pro Ile Val Asn Gly Lys Gly 
            420                 425                 430         


Val Glu Ser Pro Glu Pro Asp Tyr Trp Leu Ser Ile Tyr Glu Leu Pro 
        435                 440                 445             


Ala Met Leu Phe Tyr Ala Tyr Leu Arg Glu Lys Asn Gly Lys Arg Phe 
    450                 455                 460                 


Lys Asp Tyr Lys Ser Ile Arg Glu Leu Ile Glu Gly Val Glu Lys Lys 
465                 470                 475                 480 


Ala Asp Glu Lys Asn Asp Arg Asp Lys Gly Ala Leu Met Ala Arg His 
                485                 490                 495     


Ile Asp Lys Glu Ile Ile Trp Thr Gln Thr Lys Leu Asp Glu Val Lys 
            500                 505                 510         


Arg Leu Glu Glu Lys Lys Val Ala Ala Tyr Gly Lys Lys Gly Arg Val 
        515                 520                 525             


Val Leu Lys Ser Gly Arg Met Ala Asp Leu Leu Ala His Asp Met Val 
    530                 535                 540                 


Arg Leu Gln Pro Ala Thr Lys Gly Ser Asp Lys Ile Thr Gly Ala Asn 
545                 550                 555                 560 


Phe Gln Ala Leu Gln Val Ser Leu Ala Tyr Phe Lys Arg Asp Ile Leu 
                565                 570                 575     


Ala Asp Val Phe Ser Arg Ala Met Leu Thr Thr Gly Asn His Arg His 
            580                 585                 590         


Pro Phe Leu Tyr Arg Ile Asp Val Ser His Cys Ser Ser Leu Arg Asp 
        595                 600                 605             


Phe Tyr Val Ala Tyr Leu Gly Glu Arg Arg Lys Tyr Phe Glu Asp Val 
    610                 615                 620                 


Ala Lys Lys Ile Ala Lys Asn Lys Leu Asn Thr Pro Cys His Ile Leu 
625                 630                 635                 640 


Arg Arg Leu Gln Arg Glu Gly Ser Gly Glu Glu Ala Gly Lys Asp Val 
                645                 650                 655     


Lys Pro Lys Phe Leu Pro Arg Gly Ile Phe Thr Gly Ser Ile Lys Ser 
            660                 665                 670         


Cys Leu Glu Lys Ser Ala Leu Asn Ile Asn Ile Arg Asn Ala Arg Asn 
        675                 680                 685             


Asp Val Lys Pro Val Ile Asn Ala Ala Tyr Leu Ile Leu Met Tyr Tyr 
    690                 695                 700                 


Lys Glu Ile Glu Lys Gly Glu Phe Gln Gly Phe Tyr Gly Glu Lys Arg 
705                 710                 715                 720 


Arg Tyr Asp Ile Leu Glu Glu Gly Lys Pro Leu Asp Leu Asp Glu Arg 
                725                 730                 735     


Lys Lys Ala Leu Ala Ser Ile Lys Pro Ala Lys Ile Asp Val Ser Glu 
            740                 745                 750         


Ala Asn Met Pro Met Ser Lys Glu Glu His Leu Ile Arg Lys Arg Tyr 
        755                 760                 765             


His Ala Val Cys Asn Asn Glu Ser Ala Ile Arg Met Tyr Gln Val Gln 
    770                 775                 780                 


Asp Ile Leu Leu Leu Leu Met Ala Lys Asp Ile Phe Lys Lys Ala Leu 
785                 790                 795                 800 


Ser Glu Gly Val Met Ser Lys Lys Ile Gly Leu Glu Asn Leu Asn Gly 
                805                 810                 815     


Ile Phe Asp Ala Pro Val Asn Phe Val Lys Asn Phe Asp Asn Ile Lys 
            820                 825                 830         


Leu Thr Ala Thr Gly Ile Lys Ile Lys Asp Tyr Gly Lys Val Cys Arg 
        835                 840                 845             


Leu Gly Thr Asp Phe Lys Phe Asn Ser Leu Ile Lys Ala Phe His Lys 
    850                 855                 860                 


Val Tyr Ser Lys Ser Val Glu Met Asp Tyr Ser Asp Tyr Leu Lys Glu 
865                 870                 875                 880 


Glu Glu Glu Phe Glu Lys Tyr Arg Leu Asn Met Val Lys Leu Cys Arg 
                885                 890                 895     


Glu Val Glu Arg Gly Ile Thr Glu Asp Leu His Leu Ser Leu Asp Gly 
            900                 905                 910         


Lys Ser His Leu Ser Phe Asn Asp Asp Val Ile Lys Pro Tyr Asn Asp 
        915                 920                 925             


Lys Tyr Asn Val Phe Asn Gly Asp Asp Leu Thr Phe Phe Ile Asn Ala 
    930                 935                 940                 


Arg Asn Met Phe Met His Gly Asp Tyr Lys Tyr Glu Cys Val Lys Tyr 
945                 950                 955                 960 


Val Val Ser Glu His Phe Lys Gly Ser Leu Asn Asp Val Ser Phe Ala 
                965                 970                 975     


Lys Glu Thr Tyr Gly His Phe Cys Asn Leu Leu Glu Ser Met Arg Lys 
            980                 985                 990         


Lys Thr Gly Leu Arg Ile Asp Ile  
        995                 1000 


<210>  1772
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1772

Leu Gln Lys Gln Asp Lys Leu Phe Val Asp Arg Lys Lys Asn Ala Ile 
1               5                   10                  15      


Phe Ala Phe Pro Lys Tyr Ile Thr Ile Met Glu Asn Lys Glu Lys Pro 
            20                  25                  30          


Glu Pro Ile Tyr Tyr Glu Leu Thr Asp Lys His Phe Trp Ala Ala Phe 
        35                  40                  45              


Leu Asn Leu Ala Arg His Asn Val Tyr Thr Thr Val Asn His Ile Asn 
    50                  55                  60                  


Lys Leu Leu Glu Ile Ala Glu Leu Lys Asn Asp Glu Asp Val Leu Asn 
65                  70                  75                  80  


Ile Lys Asp Ser Trp Asn Lys Gln Ala Glu Lys Leu Asp Lys Lys Val 
                85                  90                  95      


Arg Leu Arg Asn Leu Leu Met Arg His Phe Pro Phe Leu Glu Ala Ala 
            100                 105                 110         


Ala Tyr Glu Lys Thr Thr Ser Lys Asp Ser Asn Ser Lys Glu Gln Lys 
        115                 120                 125             


Glu Lys Glu Gln Ala Glu Ala Leu Ser Leu Asp Asn Leu Lys Asn Val 
    130                 135                 140                 


Leu Phe Ile Phe Leu Glu Lys Leu Gln Ser Leu Arg Asn Tyr Tyr Ser 
145                 150                 155                 160 


His Tyr Lys Tyr Ser Glu Glu Ala Gln Lys Pro Thr Phe Glu Asn Asp 
                165                 170                 175     


Leu Leu Lys Asn Met Tyr Lys Ile Phe Asp Thr Asn Val Arg Leu Val 
            180                 185                 190         


Lys Arg Asp Tyr Met His His Glu Asn Val Asp Met Gln Arg Asp Phe 
        195                 200                 205             


Ser His Leu Asn Arg Lys Lys Gln Glu Gly Gln Thr Arg Lys Ile Ile 
    210                 215                 220                 


Ala Asn Pro Asn Phe Arg Tyr His Phe Ala Asp Glu Lys Gly Asp Met 
225                 230                 235                 240 


Thr Ile Ala Gly Leu Leu Phe Phe Ile Ser Leu Phe Leu Asp Lys Lys 
                245                 250                 255     


Asp Ala Ile Trp Met Gln Lys Lys Leu Lys Gly Phe Lys Asp Gly Arg 
            260                 265                 270         


Asn Leu Arg Glu Gln Met Thr Asn Glu Val Phe Cys Arg Ser Arg Ile 
        275                 280                 285             


Ser Leu Pro Lys Leu Lys Leu Glu Asn Val Gln Thr Lys Asp Trp Met 
    290                 295                 300                 


Gln Leu Asp Met Leu Asn Glu Leu Val Arg Cys Pro Lys Ser Leu Tyr 
305                 310                 315                 320 


Glu Arg Leu Arg Glu Lys Asp Arg Glu Ser Phe Lys Val Pro Phe Asp 
                325                 330                 335     


Ile Phe Ser Asp Asp Tyr Asp Ala Glu Glu Glu Pro Phe Lys Asn Thr 
            340                 345                 350         


Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe 
        355                 360                 365             


Asp Leu Asn Glu Ile Phe Glu Gln Leu Arg Phe Gln Ile Asp Leu Gly 
    370                 375                 380                 


Thr Tyr His Phe Ser Ile Tyr Asn Lys Arg Ile Gly Asp Glu Asp Glu 
385                 390                 395                 400 


Val Arg His Leu Thr His His Leu Tyr Gly Phe Ala Arg Ile Gln Asp 
                405                 410                 415     


Phe Ala Pro Gln Asn Gln Pro Glu Glu Trp Arg Lys Leu Val Lys Asp 
            420                 425                 430         


Leu Asp His Phe Glu Thr Ser Gln Glu Pro Tyr Ile Ser Lys Thr Ala 
        435                 440                 445             


Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Lys Phe Cys Ser 
    450                 455                 460                 


Thr His Asn Asn Leu Phe Pro Ser Leu Lys Thr Glu Lys Thr Cys Asn 
465                 470                 475                 480 


Gly Arg Ser Lys Phe Asn Leu Gly Thr Gln Phe Thr Ala Glu Ala Phe 
                485                 490                 495     


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu 
            500                 505                 510         


Thr Lys Asp His Pro Lys Gly Lys Gly Ile Asn Lys Ile Glu Lys Ile 
        515                 520                 525             


Ile Arg Lys Glu Ile Ser Asn Ile Tyr Ala Ile Tyr Asp Ala Phe Ala 
    530                 535                 540                 


Asn Asn Glu Ile Asn Ser Ile Ala Asp Leu Thr Arg Arg Leu Gln Asn 
545                 550                 555                 560 


Thr Asn Ile Leu Gln Gly His Leu Pro Lys Gln Met Ile Ser Ile Leu 
                565                 570                 575     


Glu Gly Arg Gln Lys Asp Met Glu Lys Glu Ala Glu Arg Lys Ile Gly 
            580                 585                 590         


Glu Met Ile Asp Asp Thr Gln Arg Arg Leu Asp Leu Leu Cys Lys Gln 
        595                 600                 605             


Thr Asn Gln Lys Ile Arg Ile Gly Lys Arg Asn Ala Gly Leu Leu Lys 
    610                 615                 620                 


Ser Gly Lys Ile Ala Asp Trp Leu Val Asn Asp Met Met Arg Phe Gln 
625                 630                 635                 640 


Pro Val Gln Lys Asp Gln Asn Asn Ile Pro Ile Asn Asn Ser Lys Ala 
                645                 650                 655     


Asn Ser Thr Glu Tyr Arg Met Leu Gln Arg Ala Leu Ala Leu Phe Gly 
            660                 665                 670         


Ser Glu Asn Phe Arg Leu Lys Ala Tyr Phe Asn Gln Met Asn Leu Val 
        675                 680                 685             


Gly Asn Asp Asn Pro His Pro Phe Leu Ala Glu Thr Gln Trp Glu His 
    690                 695                 700                 


Gln Thr Asn Ile Leu Ser Phe Tyr Arg Asn Tyr Leu Glu Ala Arg Lys 
705                 710                 715                 720 


Lys Tyr Leu Lys Gly Leu Lys Pro Gln Asn Trp Lys Gln Tyr Gln His 
                725                 730                 735     


Phe Leu Ile Leu Lys Val Gln Lys Thr Asn Arg Asn Thr Leu Val Thr 
            740                 745                 750         


Gly Trp Lys Asn Ser Phe Asn Leu Pro Arg Gly Ile Phe Thr Gln Pro 
        755                 760                 765             


Ile Arg Glu Trp Phe Glu Lys His Asn Asn Ser Lys Arg Ile Tyr Asp 
    770                 775                 780                 


Gln Ile Leu Ser Phe Gly Arg Val Gly Phe Val Ala Lys Ala Ile Pro 
785                 790                 795                 800 


Leu Tyr Phe Ala Glu Glu Tyr Lys Asp Asn Val Gln Pro Phe Tyr Asp 
                805                 810                 815     


Tyr Pro Phe Asn Ile Gly Asn Lys Leu Lys Pro Lys Lys Gly Gln Phe 
            820                 825                 830         


Leu Asp Lys Lys Glu Arg Val Glu Leu Trp Gln Lys Asn Lys Glu Leu 
        835                 840                 845             


Phe Lys Asn Tyr Pro Pro Glu Lys Arg Lys Thr Asp Leu Ala Tyr Leu 
    850                 855                 860                 


Asp Phe Leu Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys 
865                 870                 875                 880 


Asn Gln Asp Ile Val Thr Trp Leu Met Phe Lys Glu Leu Phe Asn Met 
                885                 890                 895     


Ala Thr Val Glu Gly Leu Lys Ile Gly Glu Ile His Leu Arg Asp Ile 
            900                 905                 910         


Asp Thr Asn Thr Ala Asn Glu Glu Ser Asn Asn Ile Leu Asn Arg Ile 
        915                 920                 925             


Met Pro Met Lys Leu Pro Val Lys Thr Tyr Glu Thr Asp Asn Lys Gly 
    930                 935                 940                 


Asn Ile Leu Lys Glu Arg Pro Leu Ala Thr Phe Tyr Ile Glu Glu Thr 
945                 950                 955                 960 


Glu Thr Lys Val Leu Lys Gln Gly Asn Phe Lys Val Leu Ala Lys Asp 
                965                 970                 975     


Arg Arg Leu Asn Gly Leu Leu Ser Phe Ala Glu Thr Thr Asp Ile Asp 
            980                 985                 990         


Leu Glu Lys Asn Pro Ile Thr Lys  Leu Ser Val Asp His  Glu Leu Ile 
        995                 1000                 1005             


Lys Tyr  Gln Thr Thr Arg Ile  Ser Ile Phe Glu Met  Thr Leu Gly 
    1010                 1015                 1020             


Leu Glu  Lys Lys Leu Ile Asp  Lys Tyr Ser Thr Leu  Pro Thr Asp 
    1025                 1030                 1035             


Ser Phe  Arg Asn Met Leu Glu  Arg Trp Leu Gln Cys  Lys Ala Asn 
    1040                 1045                 1050             


Arg Pro  Glu Leu Lys Asn Cys  Val Asn Ser Leu Ile  Ala Val Arg 
    1055                 1060                 1065             


Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met Tyr Asp  Ala Thr Leu 
    1070                 1075                 1080             


Phe Ala  Glu Val Lys Lys Phe  Thr Leu Phe Pro Ser  Val Asp Thr 
    1085                 1090                 1095             


Lys Lys  Ile Glu Leu Asn Ile  Ala Pro Gln Leu Leu  Glu Ile Val 
    1100                 1105                 1110             


Gly Lys  Ala Ile Lys Glu Ile  Glu Lys Ser Glu Asn  Lys Asn 
    1115                 1120                 1125         


<210>  1773
<211>  1008
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1773

Met Asp Thr Pro Asn Phe Ser Glu Arg Ile Pro Val Ser Leu Gln Ser 
1               5                   10                  15      


His Pro Tyr Tyr Phe Ala His Tyr Leu Asn Met Ala Arg His Asn Ala 
            20                  25                  30          


Tyr Val Ile Leu Glu Tyr Val Asn Arg Glu Leu Ile Lys Pro Gly Lys 
        35                  40                  45              


Asn Leu Asp Glu Asp Asn Leu Ile Gln Ser Thr Val Leu Lys Asp Gly 
    50                  55                  60                  


Tyr Phe Asp Arg Lys Pro Asp Glu Leu Ser His Arg Asn Arg Leu Leu 
65                  70                  75                  80  


Val Gln His Phe Pro Phe Leu Arg Glu Ala Glu Asn Glu Gly Ala Arg 
                85                  90                  95      


Thr Cys Asn Pro Val Ser Tyr Lys Leu Lys Thr Ala Leu Ala Ala Leu 
            100                 105                 110         


Asn Gln Trp Arg Asn Asn Ala Ser His Tyr Pro Leu Asn Gln Asn His 
        115                 120                 125             


Glu Lys Asp Phe Asp Leu Gln Pro Phe Phe Ser Phe Ala Ile Glu Ala 
    130                 135                 140                 


Cys Lys Lys Arg Met Arg Glu Val Phe Gln Pro Asp Asp Phe Tyr Leu 
145                 150                 155                 160 


Leu Glu Thr Asn Glu Lys Gln Phe Tyr Thr Leu His Asn Glu Asn Gly 
                165                 170                 175     


Phe Thr Glu Lys Gly Leu Tyr Cys Phe Ile Cys Phe Phe Leu Glu Lys 
            180                 185                 190         


Lys Tyr Ala Phe Gln Phe Leu Ala Gly Ile Lys Gly Phe Lys Asn Thr 
        195                 200                 205             


Thr Asp Asn Lys Phe Arg Ala Thr Leu Glu Thr Phe Thr Glu His Cys 
    210                 215                 220                 


Cys Arg Leu Pro Lys Pro Lys Leu Asp Ser Ser Asp Ile Lys Leu Asp 
225                 230                 235                 240 


Met Leu Gly Glu Leu Ser Arg Cys Pro Ala Pro Leu Phe Asp Leu Leu 
                245                 250                 255     


Asp Ile Glu Glu Arg Lys Lys Phe Ile Arg Glu Pro Glu Glu Val Lys 
            260                 265                 270         


Pro Asp Glu Ser Gly Asp Arg Glu Glu Val Gln Gln Val Leu Met Lys 
        275                 280                 285             


Arg Tyr Asp Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Glu Glu 
    290                 295                 300                 


Lys Asn Leu Leu Lys Gly Ile Ser Phe His Ile His Ile Gly Arg Trp 
305                 310                 315                 320 


Ile Lys Ser Glu His Thr Lys Lys Ile Met Gly Ala Glu Arg Asp Arg 
                325                 330                 335     


Arg Leu Leu Lys Asp Ile Arg Thr Phe Gly Glu Leu Lys Glu Phe Ser 
            340                 345                 350         


Pro Glu His Ala Pro Asp Tyr Trp Leu Arg Asp Gly Ile Thr Pro Asp 
        355                 360                 365             


Asp Val Asp Gln Phe Ser Pro Gln Tyr Arg Ile Val Gly Asn Arg Ile 
    370                 375                 380                 


Gly Ile Lys Leu Asn Tyr Asn Gly His Asn Arg Trp Ser Val Pro Asp 
385                 390                 395                 400 


Lys Glu Ile Asn Val Lys Pro Asp Ala Ile Ile Ser Thr Tyr Glu Phe 
                405                 410                 415     


Leu Asn Leu Phe Leu Tyr Glu His Leu Tyr Gln Lys Lys Leu Thr Gly 
            420                 425                 430         


Leu Ser Pro Ala Glu Phe Ile Gln Asp Tyr Leu Asp Arg Phe Asn Asn 
        435                 440                 445             


Phe Leu Ser Glu Phe Lys Ala Gly His Ile Arg Pro Val Gly Asp Phe 
    450                 455                 460                 


Ser Leu Glu Lys Arg Arg Gly Gln Gly Asp Glu Pro Asp Leu Thr Ala 
465                 470                 475                 480 


Arg Arg Lys Ser Leu Gln Lys Glu Leu Asp Arg Phe Val Leu Lys Gly 
                485                 490                 495     


Lys Asp Leu Pro Asp Lys Ile Arg Glu Tyr Leu Leu Gly Tyr Lys Gln 
            500                 505                 510         


Lys Ser Glu Lys Lys Gln Ala Lys Trp Ile Leu Gly Gly Met Ile Lys 
        515                 520                 525             


Glu Thr Val Tyr Trp Arg Asn Lys Ala Glu Gln Ser Pro Glu Lys Met 
    530                 535                 540                 


Arg Ser Gly Asp Met Ala Gln Gln Leu Ala Arg Asp Ile Ile Phe Leu 
545                 550                 555                 560 


Thr Pro Pro His Thr Val Lys Glu His Lys Gln Lys Leu Asn Ser Leu 
                565                 570                 575     


Glu Tyr Asp Val Leu Gln Tyr Ala Leu Ala Tyr Phe Ser Ser Asn Arg 
            580                 585                 590         


Glu Lys Leu Tyr Ser Phe Phe Lys Glu His Gln Leu Thr Val Lys Gly 
        595                 600                 605             


Asp Arg Ala His Pro Phe Leu Tyr Lys Ile Arg Leu Asp Glu Cys Gln 
    610                 615                 620                 


Gly Ile Leu Asp Phe Phe Ile Val Tyr Met Gln Gln Lys Glu Lys Trp 
625                 630                 635                 640 


Leu Gly Trp Leu Asp Arg Asn Leu Lys Ser Pro Arg Leu Asn Glu Glu 
                645                 650                 655     


Glu Phe Phe Asn Thr Tyr Ser Tyr Phe Ile Lys Thr Asp Thr Lys Arg 
            660                 665                 670         


Ala Ile Glu Met Asp Tyr Glu Ser Cys Pro Asn Tyr Leu Pro Arg Gly 
        675                 680                 685             


Ile Phe Asn Glu Pro Ile Ala Lys Ala Leu Gln Lys Ala Gly Val Lys 
    690                 695                 700                 


Ile Lys Asp Glu Asp Asn Ala Ser Tyr Ala Leu Ser Val Tyr Ser Asn 
705                 710                 715                 720 


Gly Lys Thr Gln Pro Phe Tyr Asn Lys Glu Arg Tyr Tyr Asn Lys Gly 
                725                 730                 735     


Ile Phe Arg Met Glu Glu Leu Pro Glu Lys Leu Gln Pro Lys Glu Leu 
            740                 745                 750         


Leu Gly Lys Ile Gln Trp Thr Ile Lys Ser Ser Gly Lys Asp Thr Glu 
        755                 760                 765             


Glu Phe Arg Ser Leu Gln Asn Leu Lys Asn Arg Ile Leu Asn Thr Glu 
    770                 775                 780                 


Lys Glu Ile Arg Tyr Val Gln Ser Thr Asp Arg Ala Leu Trp Ile Met 
785                 790                 795                 800 


Val Ala Asp Leu Phe Pro Glu Thr Phe Glu Leu Arg Pro Asp Asp Leu 
                805                 810                 815     


Glu Cys Ile Gly His Asp Leu Ser Asp Asp Leu Leu Ser Arg Pro Tyr 
            820                 825                 830         


Gln Met Lys Glu Lys Val Tyr Asn Tyr Thr Ile Thr Asp Tyr Leu Pro 
        835                 840                 845             


Ile Lys Arg Tyr Gly Glu Phe Arg Arg Phe Leu Lys Asp Arg Arg Leu 
    850                 855                 860                 


Glu Asn Leu Leu Thr Tyr Phe Glu Glu Gly Val Pro Leu His Arg Glu 
865                 870                 875                 880 


Ala Leu Val Ala Glu Leu Glu Ala Tyr Asp Leu Gln Arg Lys Asn Leu 
                885                 890                 895     


Leu Glu Ile Ile Tyr Arg Phe Glu Lys Leu Val Phe Asp Arg His Arg 
            900                 905                 910         


His Glu Leu Thr Phe Ser Gly Glu Gly Glu Asn Gln Tyr Val Asn His 
        915                 920                 925             


Trp Asp Tyr Leu Asp Phe Val Ala Arg Lys Tyr Gly Leu Ser Ala Glu 
    930                 935                 940                 


Val Lys Glu Leu Asn Ser Glu Arg Phe Thr Glu Leu Arg Asn Lys Met 
945                 950                 955                 960 


Leu His Asn Gln Ile Pro Tyr Gln Leu Trp Ile Lys Glu Ala Ile Ala 
                965                 970                 975     


Ala Arg Glu Glu Asn Thr Val Cys Gly Arg Ile Met Gly Met Ile Gly 
            980                 985                 990         


Glu Ile Tyr Glu Arg Met Thr Thr  Glu Ile Glu Lys Gln  Met Gln Val 
        995                 1000                 1005             


<210>  1774
<211>  1211
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1774

Met Asn Tyr Thr Ala Lys Ser Asp Phe Lys Lys Ile Phe Glu Asn Lys 
1               5                   10                  15      


Gly Tyr Val Gly Ala Leu Ala Glu Lys Ser Ser Asn Asn Phe Glu Tyr 
            20                  25                  30          


Ile Tyr Lys Asn Thr Val Asn Arg Asn Ser Arg Leu Phe Tyr Phe Ala 
        35                  40                  45              


Val Gly His Lys Phe Lys Asn Leu Pro Val Pro Ala Ser Ile Leu Phe 
    50                  55                  60                  


Arg Lys Glu Tyr Asp Glu Lys Ala Gly Asp Phe Gln Cys Asn Asp Phe 
65                  70                  75                  80  


Thr Tyr Leu Gln Glu Lys Asn Phe Arg Asn Val Asn Gly Glu Glu Leu 
                85                  90                  95      


Leu Lys Lys Thr Ile Gly Gly Ile Arg Asn Leu Asn Ser His Tyr Val 
            100                 105                 110         


His Leu Phe Glu Pro Leu Ser Ile Asp Asp Lys Ser Lys Pro Val Ala 
        115                 120                 125             


Leu Phe Leu Lys Asp Ala Phe Arg Met Ala Thr Leu Val Gln Phe Leu 
    130                 135                 140                 


Asp Lys Glu Lys Ala Trp Glu Arg Leu Trp Lys Glu Ala Gly Ser Ala 
145                 150                 155                 160 


Phe Pro Glu Gly Asp Tyr Phe Ala Glu Gln Ile Asn Pro Lys Leu Leu 
                165                 170                 175     


Glu Lys Tyr Val Arg Tyr Ile Ser Asp Ser Ser Phe Lys Ala Arg Tyr 
            180                 185                 190         


Lys Gln Phe Leu Tyr Glu Lys Phe Arg Gln Asp Lys Lys Lys Gln Gly 
        195                 200                 205             


Ser Arg Ala Asn Gly Asp Gly Ala Ser Ser Ser Asn Ala Ser Gly Phe 
    210                 215                 220                 


Pro Glu Glu Trp Ser Ile Asp Ala Cys Leu Asp Asn Leu Leu Phe Thr 
225                 230                 235                 240 


Glu Val Gln Gln Glu Ile Glu Trp Lys Leu Tyr Asn Lys Tyr Pro Ile 
                245                 250                 255     


Ile Asn Ile Gly Val Gly Thr Tyr Ile Ser Phe Ile Gly Met Leu Phe 
            260                 265                 270         


Leu Leu Ser Met Phe Leu Tyr Lys Asp Glu Ala Asp Leu Leu Ile Ser 
        275                 280                 285             


Lys Ile Ser Gly Tyr Lys Lys Asn Asp Asp Asp Glu Met Arg Cys Lys 
    290                 295                 300                 


Arg Asn Ile Met Ser Phe Phe Ser Lys Lys Leu Ser Ser Gln Asp Tyr 
305                 310                 315                 320 


Asp Ser Glu Glu Lys His Leu Ile Tyr Phe Arg Asp Ile Ile Gln Tyr 
                325                 330                 335     


Leu Asn Lys Tyr Pro Thr Glu Trp Asn Lys Lys Val Asp Leu Asp Asn 
            340                 345                 350         


Glu Thr Asp Ser Leu Phe Ser Ala Ala Leu Lys Gln Lys Ile Glu Glu 
        355                 360                 365             


Met Glu Ile Asn Arg Leu Phe Pro Tyr Met Arg Asp Asp Val Asp Phe 
    370                 375                 380                 


Lys His Phe Ala Val Glu Arg Leu Phe Arg Lys Lys His Val Glu Pro 
385                 390                 395                 400 


Leu Lys Pro Ile Tyr Ser Ala Leu Ile Glu Lys Asn Glu Leu Leu Gly 
                405                 410                 415     


Thr Ile Tyr Arg Gln Val Glu Ser His Asn Leu Leu Gly Gly Glu Tyr 
            420                 425                 430         


Lys Gly Phe Glu Phe Lys Glu Tyr Val Leu Lys Tyr Val Leu Asn Thr 
        435                 440                 445             


Phe Phe Pro Gly Lys Thr Asp Trp Ser Glu Tyr Arg Asn Lys Thr Phe 
    450                 455                 460                 


Glu Lys Glu Glu Thr His Glu Ala Lys Leu Asn Thr Asn Lys Glu Val 
465                 470                 475                 480 


Ala Lys Leu Lys Glu Arg Leu Lys Gln Lys Leu Phe Tyr Thr Ser Tyr 
                485                 490                 495     


Gly Arg Asn Gln Asp Arg Phe Met Glu Met Ala Ile Arg Tyr Leu Ala 
            500                 505                 510         


Thr Glu Glu Tyr Phe Gly Lys Asp Ala Lys Phe Lys Met Tyr Lys Phe 
        515                 520                 525             


Lys Thr Val Glu Glu Gln Thr Asp Tyr Leu Glu Ala Val Glu Asn Asp 
    530                 535                 540                 


Lys Ser Met Ser Lys Gln Glu Leu Asp Lys Gln Lys Phe His Asn Gly 
545                 550                 555                 560 


Lys Leu Thr Tyr Tyr Ala Thr Tyr Ser Glu His Cys Lys Lys Tyr Pro 
                565                 570                 575     


Glu Trp Asp Met Pro Phe Val Ile Glu Asn Asn Ser Phe Lys Val Gln 
            580                 585                 590         


Leu Lys Leu Ser Glu Thr Glu Ile Ser Glu Thr Glu Val Ser Ile Gln 
        595                 600                 605             


Arg Ser Leu Leu Val Tyr Leu Leu Gln Asp Arg Leu Phe Pro Pro Glu 
    610                 615                 620                 


Gly Phe Tyr Lys Thr Ser Gly Glu Ser Leu Phe Gln Glu Tyr Tyr Lys 
625                 630                 635                 640 


Gly Tyr Lys Asp Arg Leu Lys Thr Ala Cys Gln Ala Phe Glu Asn Lys 
                645                 650                 655     


Ser Val Glu Gln Leu Thr Ser Ile Lys Lys Leu Leu Pro Arg Arg Ala 
            660                 665                 670         


Val Lys Arg Gln Phe Ser Asp Glu Pro Met Gln Gln Pro Thr Tyr Ala 
        675                 680                 685             


Leu Tyr Lys Ile Leu Glu Glu Ala Arg Arg Gln Glu Glu Arg Tyr Glu 
    690                 695                 700                 


Gln Leu Leu Ala Tyr Lys Arg Ala Thr Ala Arg Ser Ile Gln Ser Ser 
705                 710                 715                 720 


Glu Val Tyr Asp His Phe Ile His Lys Asn Lys Gly Lys Gln Phe Lys 
                725                 730                 735     


Leu Arg Phe Ile Arg Lys Ala Trp Asn Leu Met Tyr Phe Lys Asp Ile 
            740                 745                 750         


Tyr Lys Asn Ser Leu Ser Thr Cys Gly Gln His His Lys Ser Phe His 
        755                 760                 765             


Ile Thr Arg Asp Glu Tyr Asn Asp Phe Cys Arg Tyr Leu Phe Ala Met 
    770                 775                 780                 


Asp Thr Val Pro Asp Tyr Lys Ser Arg Leu Arg Met Leu Leu Asp Gln 
785                 790                 795                 800 


Lys Ser Phe Phe Ala Asp Lys Ala Phe Glu Arg Leu Phe Asn Glu Gly 
                805                 810                 815     


His Ser Leu Asp Glu Tyr Tyr Arg Lys Thr Lys Val Leu Phe Lys Glu 
            820                 825                 830         


Trp Ala Asp Lys Gln Gln Ser Val Ala Val Pro Lys Glu Lys Tyr Arg 
        835                 840                 845             


Leu Lys Asn Tyr Lys Asn Phe Ser Glu Lys Val Ile Leu Tyr Ile Asn 
    850                 855                 860                 


Leu Ser Asp Phe Ile Ala Phe Leu Ile Glu Lys Lys Arg Leu Gln Thr 
865                 870                 875                 880 


Asn Ala Glu His Lys Leu Cys Leu Pro Ala Leu Arg Asn Ile Glu His 
                885                 890                 895     


Leu Ile Ser Gly Phe Tyr Ser Val Glu Asp Glu Thr Thr Ser Arg Ser 
            900                 905                 910         


Met Cys Lys Lys Leu Met Ala Asn Arg Leu Glu Asp Cys Leu Leu Tyr 
        915                 920                 925             


Glu Met Ala Ile Cys Tyr Leu Gln Lys Glu Lys Lys Lys Glu Ile Lys 
    930                 935                 940                 


Gln Leu Asn Arg Arg Gly Val Asp Val Ile Leu Asn Thr Asn Gln Val 
945                 950                 955                 960 


Leu Pro Ile Glu Ile Lys Pro Asp Lys Gly Lys Thr Lys Pro Asp Lys 
                965                 970                 975     


Asp Lys Thr Gln Gly Glu Val Tyr Tyr Ile Glu Met Pro Phe Asn His 
            980                 985                 990         


Ile Glu Lys Tyr Val Gly Ile Val  Ser Leu Lys Ile Lys  Lys Glu Glu 
        995                 1000                 1005             


Lys Gly  His Arg Ser Phe Leu  Ser Asp Leu Pro Gly  Tyr Ile Lys 
    1010                 1015                 1020             


Leu Val  Asn Asp Lys Leu Val  Asn Glu Lys Asn Arg  Pro Asn Gly 
    1025                 1030                 1035             


Arg Gly  Ser Lys Glu Leu Glu  Lys Ile Ser Arg Ile  Tyr Gln Asn 
    1040                 1045                 1050             


Tyr Leu  Glu Arg Gly Asn Lys  Ile Leu Leu Glu Glu  Tyr Asn Ser 
    1055                 1060                 1065             


Ile Gln  Arg His Ile Val Thr  Glu Ala Gly Lys Phe  Ile Ser Leu 
    1070                 1075                 1080             


Tyr Met  Glu Leu Glu Lys Tyr  Phe Ile Tyr Tyr Ser  Ile Tyr Asn 
    1085                 1090                 1095             


Asn Lys  Met Gln Leu Leu Ile  Ile Glu Gly Lys Arg  Asn Arg Ile 
    1100                 1105                 1110             


Thr Phe  Glu Glu Ile Pro Glu  Leu Lys Ala Leu Val  Glu Lys Glu 
    1115                 1120                 1125             


Gln Arg  Asn Thr Ala Phe His  Phe Gly Ile Pro Lys  Gly Lys Leu 
    1130                 1135                 1140             


Tyr Thr  Gln Ile Met Arg Asp  Ile Glu Asn Gly Phe  Ile Glu Gln 
    1145                 1150                 1155             


Ile Val  Lys Pro Met Asn Cys  Lys Asp Tyr Arg Ser  Ile Pro Asp 
    1160                 1165                 1170             


Glu Lys  Arg Ala Val Leu Asp  Lys Leu Tyr Glu Cys  Gln Lys Lys 
    1175                 1180                 1185             


Asp Gly  Lys Pro Lys Lys Arg  Ser Ile Asp Glu Glu  Asn Arg Tyr 
    1190                 1195                 1200             


Phe Glu  Lys Met Ile Arg Lys  Lys 
    1205                 1210     


<210>  1775
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1775

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Leu Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1776
<211>  1120
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1776

Met Glu Asp Asp Lys Lys Thr Thr Asp Ser Ile Ser Tyr Ala Leu Lys 
1               5                   10                  15      


Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val 
            20                  25                  30          


Tyr Ile Thr Val Asn His Ile Asn Lys Ile Leu Glu Glu Asp Glu Ile 
        35                  40                  45              


Asn Arg Asp Gly Tyr Glu Asn Thr Leu Glu Asn Ser Trp Asn Glu Ile 
    50                  55                  60                  


Lys Asp Ile Asn Lys Lys Asp Arg Leu Ser Lys Leu Ile Ile Lys His 
65                  70                  75                  80  


Phe Pro Phe Leu Glu Ala Ala Thr Tyr Arg Gln Asn Pro Thr Asp Thr 
                85                  90                  95      


Thr Lys Gln Lys Glu Glu Lys Gln Ala Glu Ala Gln Ser Leu Glu Ser 
            100                 105                 110         


Leu Lys Lys Ser Phe Phe Val Phe Ile Tyr Lys Leu Arg Asp Leu Arg 
        115                 120                 125             


Asn His Tyr Ser His Tyr Lys His Ser Lys Ser Leu Glu Arg Pro Lys 
    130                 135                 140                 


Phe Glu Glu Asp Leu Gln Asn Lys Met Tyr Asn Ile Phe Asp Val Ser 
145                 150                 155                 160 


Ile Gln Phe Val Lys Glu Asp Tyr Lys His Asn Thr Asp Ile Asn Pro 
                165                 170                 175     


Lys Lys Asp Phe Lys His Leu Asp Arg Lys Arg Lys Gly Lys Phe His 
            180                 185                 190         


Tyr Ser Phe Ala Asp Asn Glu Gly Asn Ile Thr Glu Ser Gly Leu Leu 
        195                 200                 205             


Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Val Gln 
    210                 215                 220                 


Lys Lys Leu Glu Gly Phe Lys Cys Ser Asn Glu Ser Tyr Gln Lys Met 
225                 230                 235                 240 


Thr Asn Glu Val Phe Cys Arg Ser Arg Met Leu Leu Pro Lys Leu Arg 
                245                 250                 255     


Leu Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu Asn 
            260                 265                 270         


Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Gln Gly Val 
        275                 280                 285             


Asn Arg Lys Lys Phe Tyr Val Ser Phe Asp Pro Ala Asp Glu Asp Tyr 
    290                 295                 300                 


Asp Ala Glu Gln Glu Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp 
305                 310                 315                 320 


Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Tyr Asn Glu Ile Phe 
                325                 330                 335     


Thr Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile 
            340                 345                 350         


Tyr Lys Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg His Leu Thr His 
        355                 360                 365             


Lys Leu Tyr Gly Phe Glu Arg Ile Gln Glu Phe Asp Lys Gln Asn Arg 
    370                 375                 380                 


Pro Asp Glu Trp Lys Ala Ile Val Lys Asp Ser Asp Thr Phe Lys Lys 
385                 390                 395                 400 


Lys Glu Glu Lys Glu Glu Glu Lys Pro Tyr Ile Ser Glu Thr Thr Pro 
                405                 410                 415     


His Tyr His Leu Glu Asn Lys Lys Ile Gly Ile Ala Phe Lys Asn His 
            420                 425                 430         


Asn Ile Trp Pro Ser Thr Gln Thr Glu Leu Thr Asn Asn Lys Arg Lys 
        435                 440                 445             


Lys Tyr Asn Leu Gly Thr Ser Ile Lys Ala Glu Ala Phe Leu Ser Val 
    450                 455                 460                 


His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Lys Thr Glu 
465                 470                 475                 480 


Asn Thr Lys Asn Asp Asn Lys Val Glu Gly Lys Lys Glu Thr Lys Lys 
                485                 490                 495     


Gln Gly Lys His Lys Ile Glu Ala Ile Ile Glu Ser Lys Ile Lys Asp 
            500                 505                 510         


Ile Tyr Ala Leu Tyr Asp Ala Phe Ala Asn Gly Glu Ile Asn Ser Glu 
        515                 520                 525             


Asp Glu Leu Lys Glu Tyr Leu Lys Gly Lys Asp Ile Lys Ile Val His 
    530                 535                 540                 


Leu Pro Lys Gln Met Ile Ala Ile Leu Lys Asn Glu His Lys Asp Met 
545                 550                 555                 560 


Ala Glu Lys Ala Glu Ala Lys Gln Glu Lys Met Lys Leu Ala Thr Glu 
                565                 570                 575     


Asn Arg Leu Lys Thr Leu Asp Lys Gln Leu Lys Gly Lys Ile Gln Asn 
            580                 585                 590         


Gly Lys Arg Tyr Asn Ser Ala Pro Lys Ser Gly Glu Ile Ala Ser Trp 
        595                 600                 605             


Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln Lys Asp Glu Asn 
    610                 615                 620                 


Gly Glu Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln Leu 
625                 630                 635                 640 


Leu Gln Arg Thr Leu Ala Phe Phe Gly Ser Glu His Glu Arg Leu Ala 
                645                 650                 655     


Pro Tyr Phe Lys Gln Thr Lys Leu Ile Glu Ser Ser Asn Pro His Pro 
            660                 665                 670         


Phe Leu Asn Asp Thr Glu Trp Glu Lys Cys Asn Asn Ile Leu Ser Phe 
        675                 680                 685             


Tyr Arg Ser Tyr Leu Glu Ala Lys Lys Asn Phe Leu Glu Ser Leu Lys 
    690                 695                 700                 


Pro Glu Asp Trp Glu Lys Asn Gln Tyr Phe Leu Met Leu Lys Glu Pro 
705                 710                 715                 720 


Lys Thr Asn Arg Lys Thr Leu Val Gln Gly Trp Lys Asn Gly Phe Asn 
                725                 730                 735     


Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg Lys Trp Phe Met Glu 
            740                 745                 750         


His Trp Lys Ser Ile Lys Val Asp Asp Ser Lys Arg Val Gly Leu Val 
        755                 760                 765             


Ala Lys Val Ile Pro Leu Phe Phe Ser Glu Lys Tyr Lys Asp Ser Val 
    770                 775                 780                 


Gln Pro Phe Tyr Asn Tyr Pro Phe Asn Val Gly Asp Val Asn Lys Pro 
785                 790                 795                 800 


Lys Glu Glu Asp Phe Leu His Arg Glu Glu Arg Ile Glu Leu Trp Asp 
                805                 810                 815     


Lys Lys Lys Asp Lys Phe Lys Gly Tyr Lys Ala Lys Lys Lys Phe Lys 
            820                 825                 830         


Glu Met Thr Asp Lys Glu Lys Glu Glu His Arg Ser Tyr Leu Glu Phe 
        835                 840                 845             


Gln Ser Trp Asn Lys Phe Glu Arg Glu Leu Arg Leu Val Arg Asn Gln 
    850                 855                 860                 


Asp Ile Val Thr Trp Leu Leu Cys Thr Glu Leu Ile Asp Lys Leu Lys 
865                 870                 875                 880 


Ile Asp Glu Leu Asn Ile Lys Glu Leu Lys Lys Leu Arg Leu Lys Asp 
                885                 890                 895     


Ile Asn Thr Asp Thr Ala Lys Glu Glu Lys Asn Asn Ile Leu Asn Arg 
            900                 905                 910         


Val Met Pro Met Glu Leu Pro Val Thr Val Tyr Glu Val Asn Lys Gly 
        915                 920                 925             


Gly Tyr Ile Ile Lys Asn Lys Pro Leu His Thr Ile Tyr Ile Lys Glu 
    930                 935                 940                 


Ala Glu Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys 
945                 950                 955                 960 


Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Val Lys Thr Pro Ser Glu 
                965                 970                 975     


Ala Glu Ser Glu Ser Asn Pro Ile Ser Lys Ser Arg Val Glu Ser Glu 
            980                 985                 990         


Leu Gly Lys Tyr Gln Asn Ala Arg  Leu Asp Ile Ile Glu  Asp Met Leu 
        995                 1000                 1005             


Ala Leu  Glu Lys Lys Leu Ile  Asp Lys Tyr Asn Ser  Leu Asp Thr 
    1010                 1015                 1020             


Asp Asn  Phe His Asn Met Leu  Thr Gly Trp Leu Glu  Leu Lys Gly 
    1025                 1030                 1035             


Glu Ala  Asn Lys Ala Arg Phe  Gln Asn Asp Val Lys  Leu Leu Thr 
    1040                 1045                 1050             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asn 
    1055                 1060                 1065             


Glu Asn  Leu Phe Gly Asn Ile  Glu Arg Phe Ser Leu  Ser Ser Ser 
    1070                 1075                 1080             


Asn Ile  Ile Glu Ser Lys Gly  Leu Asn Ile Ala Val  Lys Leu Lys 
    1085                 1090                 1095             


Glu Glu  Val Ser Lys Ala Ala  Lys Lys Ile Gln Asn  Glu Glu Asp 
    1100                 1105                 1110             


Asn Lys  Lys Glu Lys Glu Thr  
    1115                 1120 


<210>  1777
<211>  1334
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1777

Met Asn Met Gly Lys Asp Asn Lys Lys Tyr Gln Asp Lys Arg Gln Gly 
1               5                   10                  15      


Gln Lys Ser Glu Gln Pro Lys Lys Val Arg Arg Ile Gln Thr Lys Asp 
            20                  25                  30          


Phe Ser Ile Ser Leu Thr Gly Lys His Val Phe Gly Ala Tyr Phe Asn 
        35                  40                  45              


Met Ala Arg Thr Asn Phe Val Lys Thr Ile Asn Tyr Val Leu Pro Ile 
    50                  55                  60                  


Ala Gly Val Arg Gly Asn Tyr Ser Glu Ser Gln Ile Asn Lys Met Leu 
65                  70                  75                  80  


Gln Ala Leu Phe Leu Ile Gln Ala Asn Arg Asn Thr Glu Leu Thr Gln 
                85                  90                  95      


Glu Gln Gln Gln Trp Arg Lys Lys Leu Ile Leu Thr Pro Glu Gln Gln 
            100                 105                 110         


Thr Arg Leu Gln Arg Leu Leu Phe Lys His Phe Pro Val Leu Gly Pro 
        115                 120                 125             


Leu Met Ala Asp Val Ala Asp His Lys Ala Tyr Leu Asn Lys Lys Lys 
    130                 135                 140                 


Ser Lys Val Gln Thr Glu Asp Glu Ala Phe Glu Gln Leu Arg Gly Val 
145                 150                 155                 160 


Ser Leu Ala Asp Cys Leu Glu Met Ile Ser Leu Met Gly Glu Thr Leu 
                165                 170                 175     


Thr Glu Cys Arg Asn Tyr Tyr Thr His Arg Asn Pro Tyr Asn Ser Pro 
            180                 185                 190         


Ser Glu Leu Ala Lys Gln Tyr Met His Gln Ala Thr Ile Ala Lys Lys 
        195                 200                 205             


Leu Asp Lys Val Val Val Ala Ser Arg Arg Ile Leu Lys Asp Arg Glu 
    210                 215                 220                 


Gly Leu Ser Val Asn Glu Val Glu Phe Leu Thr Gly Val Asp Arg Met 
225                 230                 235                 240 


Lys Gln Val Asp Val Leu Asp Glu Asn Gly Lys Val Lys Met Val Asn 
                245                 250                 255     


Gly Lys Lys Met Lys Ser Phe Gln Glu Tyr Glu Asp Phe Tyr Phe Thr 
            260                 265                 270         


Leu Trp Ala Lys Arg Pro Val Val Gly Ile Thr Met Thr Gly Leu Asp 
        275                 280                 285             


Gly Asn Leu Thr Thr Ile Asp Thr Lys Leu Pro Ala Leu Ser Asp Phe 
    290                 295                 300                 


Gly Leu Leu Tyr Phe Cys Val Leu Phe Leu Ser Lys Ser Tyr Ala Lys 
305                 310                 315                 320 


Leu Phe Met Asp Glu Ala Arg Leu Phe Glu Phe Ser Pro Phe Thr Glu 
                325                 330                 335     


Gln Glu Asn Ile Ile Met Gln Glu Met Leu Cys Ile Tyr Arg Ile Arg 
            340                 345                 350         


Thr Pro Gln Pro His Arg Ile Asp Ser Arg Asp Asn Lys Ala Thr Leu 
        355                 360                 365             


Ser Met Asp Met Phe Gly Glu Leu Arg Arg Cys Pro Ile Glu Leu Tyr 
    370                 375                 380                 


Asp Leu Leu Asp Lys Thr Ala Gly Gln Pro Phe Phe His Asp Lys Val 
385                 390                 395                 400 


Lys Arg Pro Asn Ser Tyr Thr Pro Glu Val Ser Lys Arg Leu Arg Tyr 
                405                 410                 415     


Thr Asp Arg Phe Pro Gln Leu Ala Leu Arg Tyr Ile Asp Glu Asn Asp 
            420                 425                 430         


Leu Phe Lys Arg Ile Arg Phe Gln Leu Gln Leu Gly Ser Phe Arg Phe 
        435                 440                 445             


Lys Phe Tyr Asp Lys Asn Asp Cys Ile Asp Gly Arg Val Arg Val Arg 
    450                 455                 460                 


Arg Ile Gln Lys Glu Ile Asn Gly Tyr Gly Arg Pro Gln Glu Val Asn 
465                 470                 475                 480 


Glu Asn Arg Phe Gln Lys Trp Asp Gly Leu Ile Gln Lys Arg Glu Glu 
                485                 490                 495     


Arg Ser Val Lys Leu Glu His Glu Glu Leu Tyr Ile Asp Leu Asp Gln 
            500                 505                 510         


Phe Leu Gln Asp Ser Ala Asp Ser Thr Pro Tyr Ile Thr Asp Arg His 
        515                 520                 525             


Pro Thr Tyr Asn Ile His Ala Asn Arg Ile Gly Met Tyr Trp Glu Glu 
    530                 535                 540                 


Ser Gln Ile Pro Lys Gln Phe Lys Tyr Phe Asp Gly Asn Lys Met Tyr 
545                 550                 555                 560 


Ile Pro Glu Leu Ile Val Gly Asn Asp Gly Lys Ala Pro Ile Val Met 
                565                 570                 575     


Pro Ala Pro Arg Cys Ser Leu Ser Val Tyr Asp Leu Thr Gly Met Leu 
            580                 585                 590         


Phe Tyr Glu Tyr Leu Arg Asn Gln Ser Ser Thr Asp Tyr Leu Ser Ala 
        595                 600                 605             


Glu Gln Ile Ile Ile Asn Cys Glu Ser Asp Tyr Arg Arg Phe Phe Cys 
    610                 615                 620                 


Ala Val Ala Asp Gly Thr Leu Lys Pro Phe Pro Lys Thr Lys Glu Leu 
625                 630                 635                 640 


His Asp Tyr Leu Ala Arg Glu Tyr Pro Asn Leu His Ile Ala Asp Ile 
                645                 650                 655     


Pro Gln Lys Leu Leu Phe Tyr Leu Ser Gly Lys Gly Leu Thr His Asn 
            660                 665                 670         


Asn Met Pro Glu Thr Val Arg Gln Arg Leu Val Arg Leu Thr Leu Glu 
        675                 680                 685             


His Leu Glu Glu Arg Glu Gln Lys Val Lys Tyr Arg Leu Glu His Tyr 
    690                 695                 700                 


Glu Glu Asp Arg Lys Val Ile Gly Asn Lys Glu Asn Lys Tyr Gly Lys 
705                 710                 715                 720 


Lys Asn Phe Ala Asp Val Arg His Gly Ala Leu Ala Arg Tyr Leu Ala 
                725                 730                 735     


Gln Ser Met Met Glu Trp Gln Pro Thr Lys Asp Gly Val Gly His Asp 
            740                 745                 750         


Lys Leu Thr Gly Leu Asn Tyr Asn Val Leu Thr Ala Tyr Leu Ala Thr 
        755                 760                 765             


Phe Gly Val Ala Gln Pro Lys Asp Asp Phe Asp Ile Thr Pro Cys Ser 
    770                 775                 780                 


Leu Gln Glu Val Leu Thr Lys Ala His Leu Ile Gly Gly Ser Asn Pro 
785                 790                 795                 800 


His Pro Phe Val Ser Lys Val Ile Ser His Cys Val Ile Ala Asn Ala 
                805                 810                 815     


Lys Thr Arg Gln Lys Leu Thr Lys Glu Pro Arg Asn Ile Glu Glu Phe 
            820                 825                 830         


Tyr Leu Phe Tyr Leu Glu Glu Glu Leu Lys His Ile Arg Ser Arg Ile 
        835                 840                 845             


Gln Ser Leu Lys Ser Asn Ala Ser Asp Lys Ala Leu Ala Ala Leu Pro 
    850                 855                 860                 


Phe Val His His Asp Arg Met Arg Phe Arg Glu Arg Thr Ala Glu Glu 
865                 870                 875                 880 


Met Lys Ala Leu Ala Ser Arg Tyr Thr Thr Ile Gln Leu Pro Asp Gly 
                885                 890                 895     


Leu Phe Thr Pro Tyr Ile Val Lys Leu Leu Lys Ala Glu Tyr Ala Asp 
            900                 905                 910         


Asn Thr Ala Leu Gln Gln Lys Leu Ile Gln Gln Thr Pro Asn Lys Leu 
        915                 920                 925             


Asn Pro Ile Asn Asn Ala Ala Tyr Leu Val Thr Leu Phe Tyr Gln Met 
    930                 935                 940                 


Val Leu His Asp Ser Ala Gln Pro Phe Tyr Met Ser Asp Val Thr Tyr 
945                 950                 955                 960 


Ser Arg Leu Asn Ala Asp Asn Lys Ser Glu Thr Phe Ser Phe Lys Arg 
                965                 970                 975     


Ala Tyr Glu Leu Phe Ser Val Leu Ala Asn Asp Lys Glu Lys Phe Phe 
            980                 985                 990         


Pro Phe Glu Leu Lys Pro Leu Phe  Leu Thr Ser Ala Asp  Ile Gln Ala 
        995                 1000                 1005             


Arg Ile  Ser Ala Lys Val Lys  Asp Glu Thr Gly Asp  Pro Ile Ala 
    1010                 1015                 1020             


Arg Ile  Gly Lys Lys Gly Lys  Pro Glu Lys Asp Thr  Gln Gly Asn 
    1025                 1030                 1035             


Ile Ile  Trp Leu Arg Glu Ile  Thr Glu Lys Ile Asp  Val Tyr Val 
    1040                 1045                 1050             


Lys Ser  Arg Ser Asp Lys Asp  Leu Lys Ile Ser Pro  Asn Gln Ser 
    1055                 1060                 1065             


Trp Lys  Glu Lys Glu Glu Glu  Arg Glu Gln Lys Arg  Glu Ala Leu 
    1070                 1075                 1080             


Arg Thr  Arg Leu Asn Arg Gln  Val Asn Asp Val Lys  Asp Asn Glu 
    1085                 1090                 1095             


Arg Thr  Leu Arg Arg Phe Lys  Thr Gln Asp Met Val  Leu Phe Leu 
    1100                 1105                 1110             


Leu Ala  Lys Gly Met Phe Thr  Asp Ile Leu Asn Gly  Gln Glu Arg 
    1115                 1120                 1125             


Glu Val  Asn Trp Lys His Leu  Arg Leu Ala Lys Val  Cys Asn Asp 
    1130                 1135                 1140             


Thr Phe  Leu Arg Gln Thr Leu  Thr Phe Gln Val Pro  Val Thr Ile 
    1145                 1150                 1155             


Gly Asn  Glu Thr Ile Tyr Val  Glu Gln Glu Asn Met  Ser Leu Lys 
    1160                 1165                 1170             


Asn Tyr  Gly Glu Phe Tyr Arg  Phe Leu Thr Asp Asp  Arg Leu Lys 
    1175                 1180                 1185             


Ser Leu  Leu Glu Asn Ile Ile  Gly Glu Leu Lys Pro  Asp Gln Gln 
    1190                 1195                 1200             


Gly Arg  Leu Val Ile Ser His  Thr Asp Leu Met Ser  Glu Leu Ala 
    1205                 1210                 1215             


Ala Tyr  Asp Gln Lys Arg Ser  Thr Val Phe Lys Leu  Ile Gln Gln 
    1220                 1225                 1230             


Ile Glu  Ala Met Ile Ile Lys  Gly Asn Asp Val Leu  Cys Asn Pro 
    1235                 1240                 1245             


Asp Ser  Pro Glu Phe Trp Ser  Lys Pro Gly Leu Pro  Lys Arg Asn 
    1250                 1255                 1260             


Asn Phe  Ser Ser Leu Leu Glu  Leu Ile Asp His Leu  Asn Gln Thr 
    1265                 1270                 1275             


Ala Leu  Thr Thr Glu Glu Arg  Ser Leu Leu Val Ala  Ile Arg Asn 
    1280                 1285                 1290             


Ala Phe  Ser His Asn Ser Tyr  Asn Ile Asp Leu Ser  Leu Ile Ala 
    1295                 1300                 1305             


Gly Leu  Lys His Leu Pro Glu  Val Ala Asn Ser Ile  Leu Gln His 
    1310                 1315                 1320             


Leu Gln  Ser Val Ile Gly Ile  Ser Thr Ile Ser 
    1325                 1330                 


<210>  1778
<211>  1008
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1778

Met Asp Thr Pro Asn Phe Ser Glu Arg Ile Pro Val Ser Leu Gln Ser 
1               5                   10                  15      


His Pro Tyr Tyr Phe Ala His Tyr Leu Asn Met Ala Arg His Asn Ala 
            20                  25                  30          


Tyr Val Ile Leu Glu Tyr Val Asn Arg Glu Leu Ile Lys Pro Gly Lys 
        35                  40                  45              


Asn Leu Asp Glu Asp Asn Leu Ile Gln Ser Thr Val Leu Lys Asp Gly 
    50                  55                  60                  


Tyr Phe Asp Arg Lys Pro Asp Glu Leu Ser His Arg Asn Arg Leu Leu 
65                  70                  75                  80  


Val Gln His Phe Pro Phe Leu Arg Glu Ala Glu Asn Glu Gly Ala Arg 
                85                  90                  95      


Thr Cys Asn Pro Val Ser Tyr Lys Leu Lys Thr Ala Leu Ala Ala Leu 
            100                 105                 110         


Asn Gln Trp Arg Asn Asn Ala Ser His Tyr Pro Leu Asn Gln Asn His 
        115                 120                 125             


Glu Lys Asp Phe Asp Leu Gln Pro Phe Phe Ser Phe Ala Ile Glu Ala 
    130                 135                 140                 


Cys Lys Lys Arg Met Arg Glu Val Phe Gln Pro Asp Asp Phe Tyr Leu 
145                 150                 155                 160 


Leu Glu Thr Asn Glu Lys Gln Phe Tyr Thr Leu His Asn Glu Asn Gly 
                165                 170                 175     


Phe Thr Glu Lys Gly Leu Tyr Cys Phe Ile Cys Phe Phe Leu Glu Lys 
            180                 185                 190         


Lys Tyr Ala Phe Gln Phe Leu Ala Gly Ile Lys Gly Phe Lys Asn Thr 
        195                 200                 205             


Thr Asp Asn Lys Phe Arg Ala Thr Leu Glu Thr Phe Thr Glu His Cys 
    210                 215                 220                 


Cys Arg Leu Pro Lys Pro Lys Leu Asp Ser Ser Asp Ile Lys Leu Asp 
225                 230                 235                 240 


Met Leu Gly Glu Leu Ser Arg Cys Pro Ala Pro Leu Phe Asp Leu Leu 
                245                 250                 255     


Asp Ile Glu Glu Arg Lys Lys Phe Ile Arg Glu Pro Glu Glu Val Lys 
            260                 265                 270         


Pro Asp Glu Ser Gly Asp Arg Glu Glu Val Gln Gln Val Leu Met Lys 
        275                 280                 285             


Arg Tyr Asp Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Glu Glu 
    290                 295                 300                 


Lys Asn Leu Leu Lys Gly Ile Ser Phe His Ile His Ile Gly Arg Trp 
305                 310                 315                 320 


Ile Lys Ser Glu His Thr Lys Lys Ile Met Gly Ala Glu Arg Asp Arg 
                325                 330                 335     


Arg Leu Leu Lys Asp Ile Arg Thr Phe Gly Glu Leu Lys Glu Phe Ser 
            340                 345                 350         


Pro Glu His Ala Pro Asp Tyr Trp Leu Arg Asp Gly Ile Thr Pro Asp 
        355                 360                 365             


Asp Val Asp Gln Phe Ser Pro Gln Tyr Arg Ile Val Gly Asn Arg Ile 
    370                 375                 380                 


Gly Ile Lys Leu Asn Tyr Asn Gly His Asn Arg Trp Ser Val Pro Asp 
385                 390                 395                 400 


Lys Glu Ile Asn Val Lys Pro Asp Ala Ile Ile Ser Thr Tyr Glu Phe 
                405                 410                 415     


Leu Asn Leu Phe Leu Tyr Glu His Leu Tyr Gln Lys Lys Leu Thr Gly 
            420                 425                 430         


Leu Ser Pro Ala Glu Phe Ile Gln Asp Tyr Leu Asp Arg Phe Asn Asn 
        435                 440                 445             


Phe Leu Ser Glu Phe Lys Ala Gly His Ile Arg Pro Val Gly Asp Phe 
    450                 455                 460                 


Ser Leu Glu Lys Arg Arg Gly Gln Gly Asp Glu Pro Asp Leu Thr Ala 
465                 470                 475                 480 


Arg Arg Lys Ser Leu Gln Lys Glu Leu Asp Arg Phe Val Leu Lys Gly 
                485                 490                 495     


Lys Asp Leu Pro Asp Lys Ile Arg Glu Tyr Leu Leu Gly Tyr Lys Gln 
            500                 505                 510         


Lys Ser Glu Lys Lys Gln Ala Lys Trp Ile Leu Gly Gly Met Ile Lys 
        515                 520                 525             


Glu Thr Val Tyr Trp Arg Asn Lys Ala Glu Gln Ser Pro Glu Lys Met 
    530                 535                 540                 


Arg Ser Gly Asp Met Ala Gln Gln Leu Ala Arg Asp Ile Ile Phe Leu 
545                 550                 555                 560 


Thr Pro Pro His Thr Val Lys Glu His Lys Gln Lys Leu Asn Ser Leu 
                565                 570                 575     


Glu Tyr Asp Val Leu Gln Tyr Ala Leu Ala Tyr Phe Ser Ser Asn Arg 
            580                 585                 590         


Glu Lys Leu Tyr Ser Phe Phe Lys Glu His Gln Leu Thr Val Lys Gly 
        595                 600                 605             


Asp Arg Ala His Pro Phe Leu Tyr Lys Ile Arg Leu Asp Glu Cys Gln 
    610                 615                 620                 


Gly Ile Leu Asp Phe Phe Ile Val Tyr Met Gln Gln Lys Glu Lys Trp 
625                 630                 635                 640 


Leu Gly Trp Leu Asp Arg Asn Leu Lys Ser Pro Arg Leu Asn Glu Glu 
                645                 650                 655     


Glu Phe Phe Asn Thr Tyr Ser Tyr Phe Ile Lys Thr Asp Thr Lys Arg 
            660                 665                 670         


Ala Ile Glu Met Asp Tyr Glu Ser Cys Pro Asn Tyr Leu Pro Arg Gly 
        675                 680                 685             


Ile Phe Asn Glu Pro Ile Ala Lys Ala Leu Gln Lys Ala Gly Val Lys 
    690                 695                 700                 


Ile Lys Asp Glu Asp Asn Ala Ser Tyr Ala Leu Ser Val Tyr Ser Asn 
705                 710                 715                 720 


Gly Lys Thr Gln Pro Phe Tyr Asn Lys Glu Arg Tyr Tyr Asn Lys Gly 
                725                 730                 735     


Ile Phe Arg Met Glu Glu Leu Pro Glu Lys Leu Gln Pro Lys Glu Leu 
            740                 745                 750         


Leu Gly Lys Ile Gln Trp Thr Ile Lys Ser Ser Gly Lys Asp Thr Glu 
        755                 760                 765             


Glu Phe Arg Ser Leu Gln Asn Leu Lys Asn Arg Ile Leu Asn Thr Glu 
    770                 775                 780                 


Lys Glu Ile Arg Tyr Val Gln Ser Thr Asp Arg Ala Leu Trp Ile Met 
785                 790                 795                 800 


Val Ala Asp Leu Phe Pro Glu Thr Phe Glu Leu Arg Pro Asp Asp Leu 
                805                 810                 815     


Glu Cys Ile Gly His Asp Leu Ser Asp Asp Leu Leu Ser Arg Pro Tyr 
            820                 825                 830         


Gln Met Lys Glu Lys Val Tyr Asn Tyr Thr Ile Thr Asp Tyr Leu Pro 
        835                 840                 845             


Ile Lys Arg Tyr Gly Glu Phe Arg Arg Phe Leu Lys Asp Arg Arg Leu 
    850                 855                 860                 


Glu Asn Leu Leu Thr Tyr Phe Glu Glu Gly Val Pro Leu His Arg Glu 
865                 870                 875                 880 


Ala Leu Val Ala Glu Leu Glu Ala Tyr Asp Leu Gln Arg Lys Asn Leu 
                885                 890                 895     


Leu Glu Ile Ile Tyr Arg Phe Glu Lys Leu Val Phe Asp Arg His Arg 
            900                 905                 910         


His Glu Leu Thr Phe Ser Gly Glu Gly Glu Asn Gln Tyr Val Asn His 
        915                 920                 925             


Trp Asp Tyr Leu Asp Phe Val Ala Arg Lys Tyr Gly Leu Ser Ala Glu 
    930                 935                 940                 


Val Lys Glu Leu Asn Ser Glu Arg Phe Thr Glu Leu Arg Asn Lys Met 
945                 950                 955                 960 


Leu His Asn Gln Ile Pro Tyr Gln Leu Trp Ile Lys Glu Ala Ile Ala 
                965                 970                 975     


Ala Arg Glu Glu Asn Thr Val Cys Gly Arg Ile Met Gly Met Ile Gly 
            980                 985                 990         


Glu Ile Tyr Glu Arg Met Thr Thr  Glu Ile Glu Lys Gln  Met Gln Val 
        995                 1000                 1005             


<210>  1779
<211>  1129
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1779

Met Glu Thr Asn Gln Gln Thr His Glu Asn Arg Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Asn Asn His Val Ala Thr Asp Phe Lys Arg Lys Pro 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Asp Ala Leu Leu Cys Asn Lys Thr 
    50                  55                  60                  


Ile Lys Asn Leu Asn Trp Asn His Val His Thr Arg Ala Leu Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ser Glu Ser Leu Pro Lys Asp Glu 
                85                  90                  95      


Arg Lys Asn Ser Asp Thr Glu Gly Lys Asp Phe Thr Ser Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Ser Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Asp Ser Arg Lys Leu Ile Val 
    130                 135                 140                 


Ser Pro Glu Leu Ala Asn Phe Leu Thr Ile Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Thr Tyr Thr Lys Ala Arg Met Lys Asp Val Leu Thr Asp Ala Asp Tyr 
                165                 170                 175     


Ala Leu Val Glu Asn Leu Gln Met Val Ala Thr Asp Asn Lys Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ala Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asn Gln Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Ser 
            260                 265                 270         


Ile Ile Thr Asp Lys Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Glu Asn Leu Ile Ala Asn Ser Thr Asn Asn Glu Glu Arg 
    290                 295                 300                 


Glu Arg Ile Leu Asp Glu Ile Asp Tyr Gln Asp Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg Tyr Asn Asn Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Asp Glu Lys Asn Ile Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Asn Tyr Thr Lys Gln Phe Ala Gly Glu 
        355                 360                 365             


Gln Ala Glu Arg Lys Val Leu Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asp Pro Glu Leu Ser Gln Gln Arg Ile Asp Lys Gln 
385                 390                 395                 400 


Gln Gln Thr Ala Gly Phe Glu Gln Phe Ala Pro Arg Tyr His Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Asn Ile Ala Thr Leu Thr 
            420                 425                 430         


Ala Lys Ser Lys Ala Gly Ser Lys Val Glu His Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Gln Ala Glu Glu Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Ile Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Ser Gln Leu Pro Asp Gly Trp Asn Glu Phe Asn Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asp Ser Thr Leu Arg Tyr Leu 
        515                 520                 525             


His Gln Arg Lys Thr Ile Leu Asn Thr Ile Leu Ser Lys Tyr Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Lys Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Thr Arg Leu Lys Ala Val Glu Lys His Lys Leu 
            580                 585                 590         


Asn Lys Ser Val Lys Ile Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Glu Glu Lys Lys Lys Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Thr Asn Ala Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Asn Asp Gly His Pro Phe Leu Gln Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Gln Ala Tyr Leu Ile 
        675                 680                 685             


Glu Lys Gly Asn Lys Met Val Pro Arg Leu Asn Pro Lys Thr Asn Lys 
    690                 695                 700                 


Thr Ser Lys Val Asp Glu Ser Trp Met Met Lys Gln Phe Tyr Val Lys 
705                 710                 715                 720 


Glu Trp Lys Glu Glu Ile Ala Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Ser Arg Ile Pro Phe Thr Ile Arg Gln Trp Asp Glu Lys 
            740                 745                 750         


Glu Lys Tyr Asp Leu Asn Thr Trp Leu Arg His Val Thr Val Gly Lys 
        755                 760                 765             


Asn Asn Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe Asp 
    770                 775                 780                 


Glu Ala Leu Cys Asp Leu Leu Arg Glu Gln Leu Asp Thr Lys Ile Val 
785                 790                 795                 800 


Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Ile Trp Trp 
                805                 810                 815     


Lys Thr Arg Asn Asp Asp Thr Gln Gln Phe Tyr Gln Ser Glu Arg Glu 
            820                 825                 830         


Tyr Asn Ile Tyr Asn Glu Lys Val Arg Phe Lys Ile Asp Ser Ser Ala 
        835                 840                 845             


His Phe Ala Asp Tyr Tyr Lys Asn Ala Leu Ser Arg Ala Phe Thr Arg 
    850                 855                 860                 


Leu Lys Ala Glu Arg Glu Thr Ala Arg Gln Ser Asn Lys Arg Leu Pro 
865                 870                 875                 880 


Pro Leu Glu Tyr Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile Ala 
                885                 890                 895     


Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met Ala 
            900                 905                 910         


Val Leu Met Leu Glu Arg Leu Met Asp Asn Ser Pro Asn Leu Arg Leu 
        915                 920                 925             


Ser Lys Ile Glu Thr Leu Leu Asn Asp Thr Thr Pro Ile Arg Glu Lys 
    930                 935                 940                 


Ile Ser Ala Thr Leu Ser Phe Asp Ala Ser Gly Glu Arg Ile Ser Gly 
945                 950                 955                 960 


Lys Ser Asn Pro Thr Val Thr Lys Thr Leu Val Ala Glu Arg Lys Gln 
                965                 970                 975     


Lys Asn Tyr Thr Glu Leu Arg Lys Tyr Arg Tyr Asp Arg Arg Leu Pro 
            980                 985                 990         


Glu Leu Phe Glu Tyr Val Gln Ala  Asp Glu Ile Pro Leu  Glu Trp Leu 
        995                 1000                 1005             


Leu Glu  Glu Leu Ser Ala Tyr  Asn Asn Ala Lys Gln  Gln Val Phe 
    1010                 1015                 1020             


Asp Thr  Val Phe Thr Leu Glu  Lys Lys Ile Ile Gly  Thr Asp Pro 
    1025                 1030                 1035             


Asp Gly  Leu Lys Ser Leu Phe  Thr Gly Ala Asn Gly  Glu Leu Gln 
    1040                 1045                 1050             


Thr Gly  Asn Ile Gln His Lys  Pro Tyr Val Gln Trp  Leu Thr Asn 
    1055                 1060                 1065             


Lys Gly  Leu Ile Asn Lys Glu  Glu Lys Gln Phe Ile  Asn Met Val 
    1070                 1075                 1080             


Arg Lys  Cys Phe Ser His Asn  Gln Phe Pro Gln Arg  Lys Thr Met 
    1085                 1090                 1095             


Glu Leu  Leu Ile Pro Ala Trp  Asn Glu Lys Lys Leu  Ala Leu Gln 
    1100                 1105                 1110             


Ile Ala  Thr Val Tyr Asn Gln  Leu Ile Ala Asp Leu  Thr Asn Lys 
    1115                 1120                 1125             


Ile 
    


<210>  1780
<211>  1126
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1780

Met Glu Thr Asn Gln Lys Pro Asn Tyr Lys Lys Phe Thr Asn Glu Gln 
1               5                   10                  15      


Asp Lys Pro Phe Phe Ser Gly Tyr Leu Asn Thr Ala Lys Gln Asn Val 
            20                  25                  30          


Phe Ile Ile Phe Arg Asp Ile Ser Glu Arg Leu Gly Leu Gly Phe Asp 
        35                  40                  45              


Leu Ser Asn Asp Asp Asn Ile Met Asn Ala Asp Leu Trp Glu Tyr Leu 
    50                  55                  60                  


Lys Asn Asn Lys Arg Pro Glu Ile Thr Gln His Ile Ile Glu Lys Leu 
65                  70                  75                  80  


Met Tyr His Phe Pro Phe Ala Ser His Leu Thr Thr Asn Tyr Ala Tyr 
                85                  90                  95      


Tyr Lys Arg Lys Glu Asn Gln Ala Glu Pro Leu Asp Tyr Tyr Glu Ile 
            100                 105                 110         


Phe Glu Leu Leu Ile Lys Gln Leu Tyr Glu Tyr Arg Asn Phe Tyr Thr 
        115                 120                 125             


His Val Val His Asp Pro Val Ile Met Asn Lys Val Ile Ile Asn Gly 
    130                 135                 140                 


Met Arg Ile Leu Phe Asp Ala Ala Arg Ile Glu Val Lys Asp Arg Phe 
145                 150                 155                 160 


Asn Leu Lys Thr Glu Asp Val Asn His Leu Val Arg Leu Gly Pro Lys 
                165                 170                 175     


Gly Lys Glu Asn Lys Asn Phe Tyr Tyr Asn Phe Ser Asp Asp Glu Arg 
            180                 185                 190         


Asn Val Ser Glu Lys Gly Leu Ala Phe Phe Ile Cys Leu Gly Leu Gln 
        195                 200                 205             


Arg Lys Asp Ala Gln Ile Phe Leu Lys Ser Leu Val Gly Phe Lys Leu 
    210                 215                 220                 


Ser Glu Ser Pro Ser Gln Lys Ala Thr Leu Glu Val Tyr Thr Asn Tyr 
225                 230                 235                 240 


Ser Pro Arg Ile Pro Gln Pro Arg Leu Thr Ser Asp Asn Ser Ile Glu 
                245                 250                 255     


Gly Leu Leu Leu Asp Met Val Asn Glu Leu Lys Arg Cys Pro Lys Glu 
            260                 265                 270         


Leu Tyr His Leu Leu Ser Ile Glu Asp Arg Glu Lys Phe Lys Ala Val 
        275                 280                 285             


Lys Glu Asp Asn Thr Tyr Asp Asp Asn Asp Glu Tyr Glu Ala Met Pro 
    290                 295                 300                 


Val Leu Lys Arg Ser Arg Asn Arg Phe Phe Tyr Phe Ala Leu Arg Tyr 
305                 310                 315                 320 


Leu Asp Asn Asn Leu Gln Asn Ile Lys Phe His Ile Asp Leu Gly Asn 
                325                 330                 335     


Tyr Cys Phe His Val Tyr Glu Gln Glu Ile Glu Glu Ile Val Arg Lys 
            340                 345                 350         


Arg Arg Trp Ile Lys Arg Met Thr Ser Phe Gly Asn Leu Glu Asp Phe 
        355                 360                 365             


Ala Asp Lys Met Arg Pro Ala Tyr Trp Val Glu Lys Thr Leu Lys Leu 
    370                 375                 380                 


Glu Asp Lys Lys Val Asp Asn Pro Asn Ile Tyr Ile Thr Asp Thr Thr 
385                 390                 395                 400 


Pro His Tyr His Ile Asn Gly Gln Asn Ile Gly Ile Lys Phe Ile Asn 
                405                 410                 415     


Asn Tyr Val Ala Leu Arg Lys Asn Asn Lys Ile Trp Pro Glu Leu Pro 
            420                 425                 430         


Asp Phe Gly Asp Asn Asn Lys Thr Asn Lys Pro Arg Asn Glu Thr Pro 
        435                 440                 445             


Asp Cys Trp Leu Ser Leu Tyr Glu Leu Pro Ser Ile Val Phe Tyr His 
    450                 455                 460                 


Leu Leu Lys Gln Gln Asn Ile Gly Leu Pro Ser Val Glu Arg Ile Ile 
465                 470                 475                 480 


Asn Asp His Arg Asn Gln Ile Arg Gly Phe Phe Asn Asp Leu Glu Asn 
                485                 490                 495     


Asn Arg Ile Val Pro Ser Phe Thr Asp Thr Thr Leu Lys Ala Glu Leu 
            500                 505                 510         


Lys Asn Arg Gly Leu Lys Lys Ser Gln Ile Pro Ser Ala Ile Val Lys 
        515                 520                 525             


Tyr Leu Thr Ser Lys Pro Val Met Ser Phe Glu Ala Lys Ala Ser Lys 
    530                 535                 540                 


Arg Leu Ser Glu Leu Val Thr Glu Thr Ser Glu Lys Leu Asp Lys Ile 
545                 550                 555                 560 


Lys Arg Gln Glu Gln His Tyr Leu Lys Lys Pro Gly Ser Lys Asp Tyr 
                565                 570                 575     


Ile Asp Met Lys Cys Gly His Leu Ala Asp Phe Leu Ala Arg Asp Met 
            580                 585                 590         


Ile Ser Leu Gln Lys Pro Tyr Asn Asn Met Asp Gly Lys Ala Asn Ser 
        595                 600                 605             


Thr Glu Phe Gln Ile Leu Gln Ser Lys Leu Ala Tyr Phe Gly Lys Asn 
    610                 615                 620                 


Lys Asp Ser Leu Ser Lys Thr Phe His Leu Phe Asn Leu Met Gly Ser 
625                 630                 635                 640 


Gln Asn Ile His Pro Phe Leu Tyr Lys Ile Asp Ile Asn Gln Cys Ile 
                645                 650                 655     


Gly Ile Leu Asp Phe Tyr Lys Lys Tyr Leu Asp His Arg Tyr Ile Tyr 
            660                 665                 670         


Phe Lys Gln Cys Leu Asn Glu Lys Arg Tyr Ser Glu Tyr His Phe Leu 
        675                 680                 685             


Lys Leu Gly Gly Lys Ser Lys Glu Gln Gly Arg Asp Tyr Phe Val Lys 
    690                 695                 700                 


Leu Ala Asn Thr Leu Gln Lys Glu Thr Val Met Asn Leu Pro Arg Gly 
705                 710                 715                 720 


Leu Phe Leu Glu Ser Ile Ile Arg Ile Leu Lys Ala Asn Asp Asn Ser 
                725                 730                 735     


Arg Pro Phe Ala Ile Glu Ile Glu Lys Met Glu Arg Val Asn Ala Ala 
            740                 745                 750         


Tyr Val Ile Asp Gln Tyr Leu Gly Arg Ile Leu Asn Asp Lys Pro Gln 
        755                 760                 765             


Val Phe Tyr Ser Tyr Asn Lys Ser Tyr Glu Phe Leu Asn Lys Leu Phe 
    770                 775                 780                 


Asp Ser Arg Lys Ile Ser Glu Lys Arg Asn Ala Leu Pro Glu Val Tyr 
785                 790                 795                 800 


Phe Asp Thr Gly Glu Leu Ala Lys Lys Thr Thr Ile Ser Val Lys Gly 
                805                 810                 815     


Gln Lys Asp Asn Glu Ile Thr Arg Ser Leu Thr Lys Thr Val Glu Gln 
            820                 825                 830         


His Ile Lys Arg Asn Arg Ile Phe Asp Glu Lys Glu Lys Thr Lys Val 
        835                 840                 845             


Tyr Asp Gln Tyr Met Ala Arg Tyr Asn Asp Phe Thr Glu Asn Glu Lys 
    850                 855                 860                 


Gln Ile Arg Leu Ala Lys Thr Cys Asp Glu Val Met Phe Met Met Ile 
865                 870                 875                 880 


Asp Asp Ile Phe Arg Lys Tyr Phe Val Leu Asp Asn Gly Thr Leu Lys 
                885                 890                 895     


Lys Lys Thr Ile Glu Ala Ile Pro Phe Ile Gln Leu Gly Asp Asp Tyr 
            900                 905                 910         


Lys Leu Gly Ser Ile Lys Pro Asp Ser Glu Lys Gly Phe Leu Ser Leu 
        915                 920                 925             


Gln Thr Thr Val Lys Leu Gln Met Pro Phe Thr Tyr Glu Thr Asn Thr 
    930                 935                 940                 


Asp Lys Val Leu Lys Val Lys Gly Ala Glu Ser Lys Leu Ser Ala Arg 
945                 950                 955                 960 


Tyr Ile Lys Thr Ile Val Arg Glu Thr Ile Lys Ile Lys Asn Tyr Gly 
                965                 970                 975     


Asp Phe Arg Ala Phe Leu Lys Asp Arg Arg Ile Ser Ser Leu Leu Pro 
            980                 985                 990         


Tyr Leu Ser Asp Arg Glu Ile His  Tyr Glu Ala Leu Gln  Lys Glu Leu 
        995                 1000                 1005             


Glu Leu  Phe Gln Lys Ala Arg  Met Glu Val Phe Asp  Arg Ile Phe 
    1010                 1015                 1020             


Arg Phe  Glu Lys Asp Ile Thr  Gly Ala Phe His Ile  Pro Lys Asn 
    1025                 1030                 1035             


Lys Asn  Gly Tyr Ile Tyr His  Thr Glu Ile Leu Lys  Gln Lys Ile 
    1040                 1045                 1050             


Asn Glu  Gly Asp Glu Arg Phe  Gly Phe Ile Lys Glu  Leu Arg Asn 
    1055                 1060                 1065             


Ala Phe  Asn His Ser Asn Tyr  Pro Ala Tyr Val Leu  Phe Lys Asp 
    1070                 1075                 1080             


Phe Ile  Asp Gly Ser Gln Phe  Asn Glu Leu Arg Asn  Tyr Lys Ser 
    1085                 1090                 1095             


Gly Asp  Thr Glu Val Glu Asn  Lys Ser Val Ile Leu  Gln Phe Lys 
    1100                 1105                 1110             


Asn Leu  Leu Ile Gln Tyr Tyr  Asp Glu Leu Thr Asp  Leu 
    1115                 1120                 1125     


<210>  1781
<211>  1167
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1781

Met Glu Thr Lys Glu Gln Ile Gly Lys Asn Val Tyr Lys Thr Ser Glu 
1               5                   10                  15      


Asn Asp Pro Leu Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg His Asn 
            20                  25                  30          


Val Phe Leu Ile Ile Asn His Leu Thr Glu Val Phe Asp Ser Leu Gly 
        35                  40                  45              


Tyr Thr Lys Ile Asn Asp Asp Glu Asp Ile Val Asn Gln Asp His Ile 
    50                  55                  60                  


Leu Ser Gln Ile Phe Asp Pro Ser Lys Lys Glu Leu Glu Asn Glu Arg 
65                  70                  75                  80  


Ile Arg Ile Tyr Asn Tyr Met Ile Lys Arg His His Leu Pro Phe Leu 
                85                  90                  95      


Lys Val Phe Asn Ser Glu Ile Leu Asn Asp Glu Asp Gly Glu Asn Met 
            100                 105                 110         


Gly Ile Asp Phe Lys Ser Leu His Asn Phe Ile Ile Lys Ser Phe Lys 
        115                 120                 125             


Thr Leu Asn Asp Leu Arg Asn Ser Tyr Ser His Tyr Leu Ala Ile Asp 
    130                 135                 140                 


Asp Asp Gly Asn Lys Ile Glu Lys Arg Ser Asn Ile Val Asp Val Ser 
145                 150                 155                 160 


Ile Lys Ser Asp Ile Lys Gln Leu Phe Lys His Ala Pro Lys Phe Ser 
                165                 170                 175     


Phe Ile Arg Asn Gln Glu Thr Gln His Glu Glu Asp Tyr Asn His Leu 
            180                 185                 190         


Asp Arg Tyr Arg Ile Phe Glu Asn Glu Thr Asn Ile Leu Thr Asp Gln 
        195                 200                 205             


Gly Leu Tyr Phe Phe Ile Asn Leu Phe Leu Glu Arg Asn His Ala Thr 
    210                 215                 220                 


Lys Phe Leu Lys Lys Ile Lys Gly Phe Lys Asn Glu Thr Thr Pro Pro 
225                 230                 235                 240 


Phe Arg Ala Thr Ile Gln Ser Phe Thr Ser Phe Ala Leu Lys Leu Pro 
                245                 250                 255     


Asp Ile Arg Leu Ser Asn Glu Arg Pro Leu Phe Ser Leu Leu Met Asn 
            260                 265                 270         


Met Leu Thr Glu Leu Asn Lys Cys Pro Lys Glu Leu Phe Asn His Leu 
        275                 280                 285             


Thr Gln Lys Asp Lys Lys Glu Phe Glu Pro Leu Leu Asn Asp Glu Glu 
    290                 295                 300                 


Lys His Asn Val Val Leu Asn Ser Thr Asn Tyr Ser Glu Ile Ser Asp 
305                 310                 315                 320 


Asp Glu Leu Asp Glu Ala Ile Arg Glu Ile Thr Ala Leu Lys Arg Tyr 
                325                 330                 335     


Asn Asp Arg Phe Pro Tyr Phe Ala Leu Arg Phe Leu Asp Glu Thr Asn 
            340                 345                 350         


Ala Leu Lys Asn Ile Arg Phe Gln Ile Thr Leu Gly Lys Leu Ile Ile 
        355                 360                 365             


Lys Arg Tyr Asp Lys Glu Ile Ala Gly Ile Glu Glu Asn Arg Arg Val 
    370                 375                 380                 


Ile Lys Thr Ile Asn Ala Phe Gly Lys Leu Ser Asp Phe Ile Asp Asn 
385                 390                 395                 400 


Glu Glu Val Val Leu Lys Glu Leu Lys Lys Asn Leu Ala Asp Asn Asn 
                405                 410                 415     


Asp Ile Arg Phe Glu Gln Tyr Ser Pro His Tyr Asn Thr Asn Asn Ile 
            420                 425                 430         


Lys Ile Ala Phe Tyr Val Phe Asp Glu Gly Asp Asp Lys Thr Lys Tyr 
        435                 440                 445             


Pro Phe Val Phe Glu Asn Lys Glu Asn Asn Ser Asp Ile Gln Asn Asn 
    450                 455                 460                 


Pro Ser Gly Phe Leu Ser Ile His Asp Leu Pro Lys Met Leu Leu Phe 
465                 470                 475                 480 


Glu Cys Leu Asp Ile Asn Leu Lys Pro Glu Asn Ile Ile Ile Asp Phe 
                485                 490                 495     


Ile Arg Ser Thr Asn Leu Glu Met Phe Asp Leu Ser Glu Leu Glu Lys 
            500                 505                 510         


Ile Arg Lys Gln Ala Asn Tyr Glu Pro Glu Tyr Phe Ser Lys Arg Ile 
        515                 520                 525             


Asn Lys Glu Lys Tyr Leu Ile Ser Lys Lys Gly Ile Lys Tyr Leu Ser 
    530                 535                 540                 


Lys Glu Val Glu Asn Asn Met Leu Glu Asp Leu Gly Leu Ser Lys Asp 
545                 550                 555                 560 


Glu Leu Ile Leu Lys Asp Lys Asp Ser Phe Met Lys Leu Thr Asn Ser 
                565                 570                 575     


Lys Lys Tyr Ile Glu Tyr Phe Ser Gln Ile Lys Tyr Gln Tyr Tyr Leu 
            580                 585                 590         


Gln Lys Arg Arg Glu Glu Leu Gln Arg His Leu Pro Lys Gly Leu Lys 
        595                 600                 605             


Ile Asp Leu Leu Pro Glu Asn Ile Leu Glu Tyr Leu Met Asp Phe Lys 
    610                 615                 620                 


Glu Arg Asn Asn Glu Gly Ile Ile His Gln Lys Val Ala Ala Ile Arg 
625                 630                 635                 640 


Asp Glu Ala Lys Asn Leu Lys Lys Ser Ile Glu Ser Glu Val Glu Lys 
                645                 650                 655     


Pro Lys Asn Glu Gln Arg Ile Lys Leu Gly Glu Leu Ala Thr Phe Val 
            660                 665                 670         


Ala Arg Asp Ile Ile Lys Met Val Ile Cys Lys Glu Val Lys Asp Lys 
        675                 680                 685             


Ile Thr Ser Pro Tyr Tyr Asn Lys Leu Gln Asn Lys Ile Ala Tyr Phe 
    690                 695                 700                 


Ser Leu Asn Lys Asp Glu Leu Ile Asp Ile Cys Asp Glu Leu Lys Leu 
705                 710                 715                 720 


Phe Asn Glu Asn Glu Gly His Val Phe Phe Lys Lys Glu Leu Ile Lys 
                725                 730                 735     


Asn Ser Asp Gly Ile Ile Asp Phe Thr Leu Asp Tyr Leu Arg Ala Lys 
            740                 745                 750         


Asp Asn Trp Ile Glu Thr Lys Leu Leu Lys Lys Gly Lys Thr Gly Gly 
        755                 760                 765             


Tyr Arg Phe Pro Asp Lys Thr Lys Ile Pro Leu Ser Phe Asn Lys Ile 
    770                 775                 780                 


Lys Asn Lys Ala Asn Ser Phe Asp Phe Lys Thr Trp Leu Lys Asn Lys 
785                 790                 795                 800 


Ser Gln Leu Pro Val Asp Leu Pro Arg Ser Leu Phe Asp Glu Lys Leu 
                805                 810                 815     


Glu Ile Ile Leu Lys Gly Lys Leu Asn Gln Lys Gly Ile Ile Phe Asn 
            820                 825                 830         


Thr Gly Asp Lys Phe Ser Val Leu Leu Ser Lys Tyr Leu Asn Asn Asp 
        835                 840                 845             


Thr Gln Val Phe Tyr Asn Tyr Cys Arg Ser Tyr Ser Ile Asn Lys Lys 
    850                 855                 860                 


Ile Glu Glu Phe Glu Ile Ser Gly Leu Ser Gly Lys Glu Ile Lys Lys 
865                 870                 875                 880 


Asn Phe Asp Ser Asn Val Glu Lys Asn Glu Lys Ser Ile Arg Phe Ile 
                885                 890                 895     


Gln Thr Lys Asp Arg Val Leu Lys Leu Ile Ser Asp Lys Ile Leu Ser 
            900                 905                 910         


Ile Asp Arg Ser Ile Gly Leu Gln Ser Gly Phe Cys Leu Thr Asp Ile 
        915                 920                 925             


His Pro Ala Ala Lys His Asn Pro Leu Asp Cys Pro Ala Val Phe Glu 
    930                 935                 940                 


Gln Lys Ile Ile Arg Arg Gly Asp Glu Val Phe Cys Asn Ile Ile Ala 
945                 950                 955                 960 


Lys Asp Thr Glu Asn Gln Ile Gln Ser Val Lys His Phe Glu Ser Leu 
                965                 970                 975     


Gln Ala Glu Glu Glu Lys Glu Ala Tyr Pro Asp Gln Lys Trp Tyr Gln 
            980                 985                 990         


Trp Thr Ile Lys Asp Phe Gly Arg  Phe Lys Arg Phe Ile  Lys Asp Arg 
        995                 1000                 1005             


Arg Ile  Pro Asn Leu Ser Asn  Tyr Phe Glu Asp Lys  Asn Ile Pro 
    1010                 1015                 1020             


Phe Asp  Leu Leu Glu Tyr Gln  Leu Arg Glu Tyr Asn  Lys Tyr Lys 
    1025                 1030                 1035             


Glu Glu  Ile Phe Glu Leu Thr  Leu Met Leu Glu Lys  Glu Ile Ile 
    1040                 1045                 1050             


Asn Tyr  Asp Phe Glu Gly Ile  Arg Thr Ile Glu Phe  Ser Glu Asn 
    1055                 1060                 1065             


Arg Arg  Pro Lys Gly Phe Tyr  Glu Ile Arg Phe Asp  Thr Tyr Met 
    1070                 1075                 1080             


Glu Trp  Leu Asp Asn Lys Asn  Ile Gln Tyr Asn Lys  Glu Arg Val 
    1085                 1090                 1095             


Lys Glu  Cys Arg Asn Lys Phe  Ser His Ser Glu Tyr  Pro Leu Phe 
    1100                 1105                 1110             


Lys Glu  Ile Ser Lys Ile Ser  Lys Gln Gln Ile Thr  Glu Phe Glu 
    1115                 1120                 1125             


Thr Asn  Lys Gln Ile Lys Asp  Tyr Lys Ser Ser Ser  Gly Ile Ser 
    1130                 1135                 1140             


Ile Ala  Glu Lys Ile Tyr Asn  Leu Tyr Lys Leu Glu  Ile Glu Arg 
    1145                 1150                 1155             


Ile Ile  Asn Ser Ile Lys Asn  Asn Ile 
    1160                 1165         


<210>  1782
<211>  1082
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1782

Met Met Tyr Asn Asp Ser Gln Gly Asn Asn Met Glu Gln Asn Ser Lys 
1               5                   10                  15      


Ser Phe Leu Gly Ile Phe Leu Asn Gln Ala Arg Leu Asn Ala Tyr Ile 
            20                  25                  30          


Ala Leu Cys His Ile Ser Asp Leu Leu Glu Lys Asn Thr Val Asp Glu 
        35                  40                  45              


Asp Ser Leu Thr Gln Met Pro Val Leu Lys Phe Leu Glu Ser Asn Lys 
    50                  55                  60                  


Asp Ala Val Lys Ser Glu Arg Ala Phe Asp Leu Ile Gly Lys Gln Phe 
65                  70                  75                  80  


Pro Met Leu Lys Val Ile Tyr Gly Ser Glu Pro Lys Asn Gly Gln Glu 
                85                  90                  95      


Asp Asn Leu Leu Glu Arg Thr Lys Lys Tyr Arg Glu Ile Leu Thr Cys 
            100                 105                 110         


Leu Leu Lys Ala Leu Asn Tyr Asn Arg Asn Glu Asn Cys His Ala His 
        115                 120                 125             


Ser Gly Lys Gly Lys Arg Asp Tyr Asp Val Lys Thr Leu Ile Arg Tyr 
    130                 135                 140                 


Leu Glu Asn Cys Phe Asp Ala Ala Val Thr Pro Ile Arg Asp Arg Tyr 
145                 150                 155                 160 


Ser Leu Asn Glu Glu Ser Val Phe His Leu Arg Arg Lys Thr Ser Glu 
                165                 170                 175     


Gly Glu Gly Lys Asp Lys Arg Val Val Asp Asn Pro Asn Phe Tyr Tyr 
            180                 185                 190         


His Phe Lys Asp Glu Gln Gly Gln Leu Asn Glu Lys Gly Leu Ala Phe 
        195                 200                 205             


Leu Thr Ser Leu Phe Leu Glu Lys Arg Asp Thr Tyr Leu Phe Leu Lys 
    210                 215                 220                 


Arg Gln Arg Gly Phe Lys Arg Gly Glu Thr Pro Ala Glu Lys Ala Thr 
225                 230                 235                 240 


Leu Glu Cys Phe Cys Cys Tyr Arg Ile Lys Leu Pro Lys Pro Val Met 
                245                 250                 255     


Thr Ser Asp Val Asp Lys Asn Gly Leu Ala Leu Asp Met Leu Asn Glu 
            260                 265                 270         


Leu Lys Lys Cys Pro Lys Glu Leu Phe Glu Leu Leu Ser Lys Asp Arg 
        275                 280                 285             


Gln Lys Asp Phe Arg Gly Ile Asp Ser Ser Asp Thr Glu Glu Asp Gly 
    290                 295                 300                 


Asn Glu Ile Leu Met Arg Arg Tyr Ser Asp Arg Phe Pro Tyr Leu Ala 
305                 310                 315                 320 


Leu Arg Tyr Cys Asp Glu Asn Glu Leu Phe Gln Asn Leu Arg Phe His 
                325                 330                 335     


Ile Asp Leu Gly Arg Tyr Tyr Phe Lys Phe Tyr Asn Lys Glu Met Ile 
            340                 345                 350         


Asp Gly Gly Thr Tyr Gln Arg Ala Leu Asp Lys Arg Leu Lys Thr Phe 
        355                 360                 365             


Gly Arg Ile Arg Asp Val Lys Glu Lys Val Glu Gln Gln Trp Lys Asp 
    370                 375                 380                 


Ile Ile Lys Ser Pro Gly Asp Asn Thr Glu Glu Lys Ser Glu Pro Cys 
385                 390                 395                 400 


Asp Asn Thr Glu Lys Gln Ser Glu Pro Tyr Lys Thr Asn Thr Thr Pro 
                405                 410                 415     


His Tyr Asn Leu Val Asp Asn Gln Ile Gly Phe Val Ile Ser Gly Asp 
            420                 425                 430         


Cys Asp Leu Pro Asp Ile Lys Gln Pro Glu Gly Lys Ile Thr Leu Gln 
        435                 440                 445             


Lys Pro Asp Ala Trp Leu Ser Ile Tyr Glu Leu Pro Gly Met Ile Phe 
    450                 455                 460                 


His Gly Leu Gly Asp Gly Phe Glu Lys Thr Glu Gly Leu Ile Lys Gln 
465                 470                 475                 480 


Tyr Ile Glu Arg Gln Arg Lys Ile Cys Lys Lys Ile Cys Glu Thr Gly 
                485                 490                 495     


Ala Ile Pro Glu Asp Ala Gly Glu Phe Leu Ser Glu Ser Leu Lys Asp 
            500                 505                 510         


Thr Gly Thr Ser Asp Ala Gly Gln Asn Asn Tyr Ala Arg Glu Lys Leu 
        515                 520                 525             


Gln Arg Met Leu Gly Asp Thr Ile Gln Arg Ile Lys Ala Leu Lys Lys 
    530                 535                 540                 


Thr Gln Asp Arg Met Ala Asp Lys Ser Asn Lys Pro Gly Lys Lys Lys 
545                 550                 555                 560 


Phe Phe Asp Ile Arg Ala Gly Lys Leu Ala Asp Phe Leu Ala Arg Asp 
                565                 570                 575     


Ile Met Ala Leu Gln Lys Phe Asp Pro Ala Lys Asn Gly Lys Asp Lys 
            580                 585                 590         


Leu Thr Ser Thr Asp Tyr Gln Val Leu Gln Ala Ser Leu Ala Phe Phe 
        595                 600                 605             


Ser Ala Lys Lys Asp Met Ile Ala Asp Ile Phe Lys Arg Ile Gly Leu 
    610                 615                 620                 


Leu Asp Gly Asp Asn Pro His Ser Phe Leu Asn Gln Ile Asn Leu Ala 
625                 630                 635                 640 


Gly Cys Asn Ser Ile Val Asp Phe Tyr Leu Ala Tyr Leu Asn Ala Lys 
                645                 650                 655     


Gln Gln Tyr Leu Glu Gly Cys Lys Lys Asp Gly Asp Leu Asp Asp Cys 
            660                 665                 670         


Gln Phe Leu Arg Pro Ser Arg Gln Arg Tyr Ala Lys Gly Lys Arg Asp 
        675                 680                 685             


Ile Lys Thr Ile Ala Lys Gln Leu Leu Asp Asn Pro Val Asn Ile Pro 
    690                 695                 700                 


Lys Gly Phe Phe Gln Lys Gln Ile Glu Glu Phe Val Cys Lys Gln Asp 
705                 710                 715                 720 


Pro Ser Leu Glu Asn Arg Glu Met Asn Thr Ala Tyr Met Ile Gln Glu 
                725                 730                 735     


Trp Phe Glu Met Thr His Gly Gly Cys Gln Pro Phe Tyr Gly Tyr Glu 
            740                 745                 750         


Lys Thr Tyr Glu Ile Val Ser Lys Ala Ala Glu Tyr Gly Lys Lys Ala 
        755                 760                 765             


Val Asn Arg Asn Ile Ala Arg Glu Leu Arg Ser Ile Thr Ala Gln Met 
    770                 775                 780                 


Ser Tyr Lys Glu Met Lys Ser Phe Ile Glu Glu Lys Ile Pro Asp Lys 
785                 790                 795                 800 


Gly Arg Tyr Asp Pro Glu Asn Leu Arg Glu Asn Leu Leu Lys Gly Cys 
                805                 810                 815     


Ser Asp Phe Lys Asp Asn Glu Arg Leu Leu Arg Arg Ser Arg Val Gln 
            820                 825                 830         


Asp Met Val Met Phe Met Met Phe Glu Thr Thr Leu Lys Glu His Leu 
        835                 840                 845             


Ser Ile Asp Gly Asn Val Val Lys Leu Gln Asp Ile Thr Leu Leu Glu 
    850                 855                 860                 


Asp Ser Pro Phe Asn Lys Pro Val Arg Cys Asp Thr Ile Ile Thr Val 
865                 870                 875                 880 


Pro Phe Asn Thr Lys Pro Glu His Tyr Asp Asn Gly Tyr Val Val Phe 
                885                 890                 895     


Ile Gln Glu Lys Tyr Lys Gly Phe Cys Ile Ser Gln Pro Asn Arg Ile 
            900                 905                 910         


Ile Leu Lys Tyr Lys Val Thr Ser Glu Asn Thr Lys Leu Lys Asp Leu 
        915                 920                 925             


Gly Lys Tyr Arg Arg Tyr Leu Tyr Asp Arg Arg Leu Pro Gly Leu Leu 
    930                 935                 940                 


Ile Trp Lys Tyr Pro Pro Asn Ala Gln Ser Asp Thr Glu Ile Lys Tyr 
945                 950                 955                 960 


Ser Tyr Ile Glu Glu Gln Ile Lys Ala Tyr Glu Gln His Arg Val Glu 
                965                 970                 975     


Ile Ala Gly Leu Leu Tyr Gly Leu Glu Asn Lys Val Ile Asp Cys Leu 
            980                 985                 990         


Met Pro Lys Asp Ala Leu Gly Asp  Gly Tyr Ile Asp Phe  Lys Glu Ile 
        995                 1000                 1005             


Ile Lys  Lys Leu Lys Asp Lys  Leu Pro Arg Phe Glu  Glu Gln Ala 
    1010                 1015                 1020             


Asp Thr  Leu Trp Asn Ile Arg  Asn Ala Phe Tyr His  Asn Gln Phe 
    1025                 1030                 1035             


Pro Val  Phe Thr Asp Ala Ile  Glu Lys Ala Asp Gly  Gly Ser Ile 
    1040                 1045                 1050             


Ala Glu  Lys Met Leu Ser Ile  Thr Gln Ser Tyr Val  Glu Gln Ile 
    1055                 1060                 1065             


Thr Lys  Glu Ile Asp Glu Ser  Asp Lys Glu Phe Thr  Asn Val 
    1070                 1075                 1080         


<210>  1783
<211>  1008
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1783

Met Asp Thr Pro Asn Phe Ser Glu Arg Ile Pro Val Ser Leu Gln Ser 
1               5                   10                  15      


His Pro Tyr Tyr Phe Ala His Tyr Leu Asn Met Ala Arg His Asn Ala 
            20                  25                  30          


Tyr Val Ile Leu Glu Tyr Val Asn Arg Glu Leu Ile Lys Pro Gly Lys 
        35                  40                  45              


Asn Leu Asp Glu Asp Asn Leu Ile Gln Ser Thr Val Leu Lys Asp Gly 
    50                  55                  60                  


Tyr Phe Asp Arg Lys Pro Asp Glu Leu Ser His Arg Asn Arg Leu Leu 
65                  70                  75                  80  


Val Gln His Phe Pro Phe Leu Arg Glu Ala Glu Asn Glu Gly Ala Arg 
                85                  90                  95      


Thr Cys Asn Pro Val Ser Tyr Lys Leu Lys Thr Ala Leu Ala Ala Leu 
            100                 105                 110         


Asn Gln Trp Arg Asn Asn Ala Ser His Tyr Pro Leu Asn Gln Asn His 
        115                 120                 125             


Glu Lys Asp Phe Asp Leu Gln Pro Phe Phe Ser Phe Ala Ile Glu Ala 
    130                 135                 140                 


Cys Lys Lys Arg Met Arg Glu Val Phe Gln Pro Asp Asp Phe Tyr Leu 
145                 150                 155                 160 


Leu Glu Thr Asn Glu Lys Gln Phe Tyr Thr Leu His Asn Glu Asn Gly 
                165                 170                 175     


Phe Thr Glu Lys Gly Leu Tyr Cys Phe Ile Cys Phe Phe Leu Glu Lys 
            180                 185                 190         


Lys Tyr Ala Phe Gln Phe Leu Ala Gly Ile Lys Gly Phe Lys Asn Thr 
        195                 200                 205             


Thr Asp Asn Lys Phe Arg Ala Thr Leu Glu Thr Phe Thr Glu His Cys 
    210                 215                 220                 


Cys Arg Leu Pro Lys Pro Lys Leu Asp Ser Ser Asp Ile Lys Leu Asp 
225                 230                 235                 240 


Met Leu Gly Glu Leu Ser Arg Cys Pro Ala Pro Leu Phe Asp Leu Leu 
                245                 250                 255     


Asp Ile Glu Glu Arg Lys Lys Phe Ile Arg Glu Pro Glu Glu Val Lys 
            260                 265                 270         


Pro Asp Glu Ser Gly Asp Arg Glu Glu Val Gln Gln Val Leu Met Lys 
        275                 280                 285             


Arg Tyr Asp Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Glu Glu 
    290                 295                 300                 


Lys Asn Leu Leu Lys Gly Ile Ser Phe His Ile His Ile Gly Arg Trp 
305                 310                 315                 320 


Ile Lys Ser Glu His Thr Lys Lys Ile Met Gly Ala Glu Arg Asp Arg 
                325                 330                 335     


Arg Leu Leu Lys Asp Ile Arg Thr Phe Gly Glu Leu Lys Glu Phe Ser 
            340                 345                 350         


Pro Glu His Ala Pro Asp Tyr Trp Leu Arg Asp Gly Ile Thr Pro Asp 
        355                 360                 365             


Asp Val Asp Gln Phe Ser Pro Gln Tyr Arg Ile Val Gly Asn Arg Ile 
    370                 375                 380                 


Gly Ile Lys Leu Asn Tyr Asn Gly His Asn Arg Trp Ser Val Pro Asp 
385                 390                 395                 400 


Lys Glu Ile Asn Val Lys Pro Asp Ala Ile Ile Ser Thr Tyr Glu Phe 
                405                 410                 415     


Leu Asn Leu Phe Leu Tyr Glu His Leu Tyr Gln Lys Lys Leu Thr Gly 
            420                 425                 430         


Leu Ser Pro Ala Glu Phe Ile Gln Asp Tyr Leu Asp Arg Phe Asn Asn 
        435                 440                 445             


Phe Leu Ser Glu Phe Lys Ala Gly His Ile Arg Pro Val Gly Asp Phe 
    450                 455                 460                 


Ser Leu Glu Lys Arg Arg Gly Gln Gly Asp Glu Pro Asp Leu Thr Ala 
465                 470                 475                 480 


Arg Arg Lys Ser Leu Gln Lys Glu Leu Asp Arg Phe Val Leu Lys Gly 
                485                 490                 495     


Lys Asp Leu Pro Asp Lys Ile Arg Glu Tyr Leu Leu Gly Tyr Lys Gln 
            500                 505                 510         


Lys Ser Glu Lys Lys Gln Ala Lys Trp Ile Leu Gly Gly Met Ile Lys 
        515                 520                 525             


Glu Thr Val Tyr Trp Arg Asn Lys Ala Glu Gln Ser Pro Glu Lys Met 
    530                 535                 540                 


Arg Ser Gly Asp Met Ala Gln Gln Leu Ala Arg Asp Ile Ile Phe Leu 
545                 550                 555                 560 


Thr Pro Pro His Thr Val Lys Glu His Lys Gln Lys Leu Asn Ser Leu 
                565                 570                 575     


Glu Tyr Asp Val Leu Gln Tyr Ala Leu Ala Tyr Phe Ser Ser Asn Arg 
            580                 585                 590         


Glu Lys Leu Tyr Ser Phe Phe Lys Glu His Gln Leu Thr Val Lys Gly 
        595                 600                 605             


Asp Arg Ala His Pro Phe Leu Tyr Lys Ile Arg Leu Asp Glu Cys Gln 
    610                 615                 620                 


Gly Ile Leu Asp Phe Phe Ile Val Tyr Met Gln Gln Lys Glu Lys Trp 
625                 630                 635                 640 


Leu Gly Trp Leu Asp Arg Asn Leu Lys Ser Pro Arg Leu Asn Glu Glu 
                645                 650                 655     


Glu Phe Phe Asn Thr Tyr Ser Tyr Phe Ile Lys Thr Asp Thr Lys Arg 
            660                 665                 670         


Ala Ile Glu Met Asp Tyr Glu Ser Cys Pro Asn Tyr Leu Pro Arg Gly 
        675                 680                 685             


Ile Phe Asn Glu Pro Ile Ala Lys Ala Leu Gln Lys Ala Gly Val Lys 
    690                 695                 700                 


Ile Lys Asp Glu Asp Asn Ala Ser Tyr Ala Leu Ser Val Tyr Ser Asn 
705                 710                 715                 720 


Gly Lys Thr Gln Pro Phe Tyr Asn Lys Glu Arg Tyr Tyr Asn Lys Gly 
                725                 730                 735     


Ile Phe Arg Met Glu Glu Leu Pro Glu Lys Leu Gln Pro Lys Glu Leu 
            740                 745                 750         


Leu Gly Lys Ile Gln Trp Thr Ile Lys Ser Ser Gly Lys Asp Thr Glu 
        755                 760                 765             


Glu Phe Arg Ser Leu Gln Asn Leu Lys Asn Arg Ile Leu Asn Thr Glu 
    770                 775                 780                 


Lys Glu Ile Arg Tyr Val Gln Ser Thr Asp Arg Ala Leu Trp Ile Met 
785                 790                 795                 800 


Val Ala Asp Leu Phe Pro Glu Thr Phe Glu Leu Arg Pro Asp Asp Leu 
                805                 810                 815     


Glu Cys Ile Gly His Asp Leu Ser Asp Asp Leu Leu Ser Arg Pro Tyr 
            820                 825                 830         


Gln Met Lys Glu Lys Val Tyr Asn Tyr Thr Ile Thr Asp Tyr Leu Pro 
        835                 840                 845             


Ile Lys Arg Tyr Gly Glu Phe Arg Arg Phe Leu Lys Asp Arg Arg Leu 
    850                 855                 860                 


Glu Asn Leu Leu Thr Tyr Phe Glu Glu Gly Val Pro Leu His Arg Glu 
865                 870                 875                 880 


Ala Leu Val Ala Glu Leu Glu Ala Tyr Asp Leu Gln Arg Lys Asn Leu 
                885                 890                 895     


Leu Glu Ile Ile Tyr Arg Phe Glu Lys Leu Val Phe Asp Arg His Arg 
            900                 905                 910         


His Glu Leu Thr Phe Ser Gly Glu Gly Glu Asn Gln Tyr Val Asn His 
        915                 920                 925             


Trp Asp Tyr Leu Asp Phe Val Ala Arg Lys Tyr Gly Leu Ser Ala Glu 
    930                 935                 940                 


Val Lys Glu Leu Asn Ser Glu Arg Phe Thr Glu Leu Arg Asn Lys Met 
945                 950                 955                 960 


Leu His Asn Gln Ile Pro Tyr Gln Leu Trp Ile Lys Glu Ala Ile Ala 
                965                 970                 975     


Ala Arg Glu Glu Asn Thr Val Cys Gly Arg Ile Met Gly Met Ile Gly 
            980                 985                 990         


Glu Ile Tyr Glu Arg Met Thr Thr  Glu Ile Glu Lys Gln  Met Gln Val 
        995                 1000                 1005             


<210>  1784
<211>  1147
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1784

Met Glu Ile Ala Thr Gln Gln Ser Glu Thr Gln Lys Lys Lys Arg Ser 
1               5                   10                  15      


Leu Asp Gln Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg 
            20                  25                  30          


His Asn Val Phe Leu Ile Val Asn His Leu Thr Asp Thr Phe Lys Glu 
        35                  40                  45              


Leu Asn Phe Lys Lys Leu Ala Asn Glu Glu Asp Ile Trp Lys Val Asp 
    50                  55                  60                  


Asn Ser Ser Asn Ile Leu Leu Asn Val Phe Asp Val Thr Gln Ser Lys 
65                  70                  75                  80  


Tyr Glu Asp Phe Arg Pro Arg Ile Phe His Tyr Leu Ile Lys Arg His 
                85                  90                  95      


His Leu Pro Leu Val Lys Ile Phe Asn Thr Glu Tyr Leu Gly Glu Asn 
            100                 105                 110         


Ile Leu Gln Asp Lys Ser Ile Asp Tyr Glu Arg Leu His Gln Phe Leu 
        115                 120                 125             


Cys Leu Ser Phe Lys Glu Leu Thr Glu Phe Arg Asn Ser Tyr Ser His 
    130                 135                 140                 


Ser Ile Ala Ile Asp Glu Asn Gly Asn Lys Val Gly Arg Lys Thr Thr 
145                 150                 155                 160 


Leu Ala Asn Asp Leu Val Pro Glu Val Asn Leu Leu Phe Lys Tyr Ala 
                165                 170                 175     


Pro Lys Tyr Ser Phe Leu Arg Asn His Gln Thr Leu Asn Glu Gly Asp 
            180                 185                 190         


Phe Gln His Leu Asp Asn Tyr Gln Leu Phe Ile Ala Asp Asn Gln Leu 
        195                 200                 205             


Thr His Gln Gly Arg Phe Phe Phe Ile Asn Leu Phe Leu Glu Arg Ser 
    210                 215                 220                 


Tyr Gly Ile Lys Phe Leu Lys Arg Phe Arg Gly Phe Lys Asn Glu Asn 
225                 230                 235                 240 


Thr Pro Pro Phe Lys Ala Thr Ile Gln Ser Phe Thr Thr Tyr Cys Leu 
                245                 250                 255     


Lys Val Pro Asp Ile Arg Leu Gly Asn Glu Asn Pro Lys Gln Ser Leu 
            260                 265                 270         


Leu Leu Asp Met Leu Thr Glu Leu Asn Lys Cys Pro Lys Glu Leu Phe 
        275                 280                 285             


Asn His Leu Thr Glu Asp Asp Lys Lys Glu Phe Glu Pro Asn Leu Asp 
    290                 295                 300                 


Glu Thr Ser Ser Thr Asn Val Leu Leu Asn Ser Thr Asn Tyr Glu Phe 
305                 310                 315                 320 


Phe Asp Thr Asp Glu Val Glu Glu Ala Ile Arg Glu Leu Thr Ala Gln 
                325                 330                 335     


Lys Arg His Ser Asp Arg Phe Pro Tyr Leu Ala Leu Arg Phe Leu Asp 
            340                 345                 350         


Glu Thr Met Ala Phe Ser Gln Leu Arg Phe Gln Leu Ser Leu Gly Lys 
        355                 360                 365             


Ile Ile Ile Lys Lys Pro Tyr Gln Lys Thr Ile Leu Gly Gln Pro Asn 
    370                 375                 380                 


Asp Arg Ile Ile Thr Lys Lys Leu Asn Val Phe Gly Arg Ile Ser Asp 
385                 390                 395                 400 


Phe Leu Asn Arg Glu Lys Glu Ile Ile Arg Ala Leu Ser Asn Asp Gln 
                405                 410                 415     


Asn Val Asp Phe Leu Glu Phe Glu Gln Phe Phe Pro His Tyr Asn Ile 
            420                 425                 430         


Asn Asn Asn Lys Ile Ala Phe Tyr Phe Leu Asn Asp Ser Asp Leu Thr 
        435                 440                 445             


Glu Glu Asn Leu Glu Ser Arg Leu Arg Asp Gln Glu Asn Arg Gln Pro 
    450                 455                 460                 


Thr Gly Phe Leu Ser Ile His Asp Leu Pro Lys Leu Val Leu Leu His 
465                 470                 475                 480 


Leu Leu Ala Pro Ser Glu Val Gln Lys Thr Leu Gln Arg Phe Ile Asn 
                485                 490                 495     


Asp Asn Asn Pro Ala Phe Phe Asp Leu Glu Leu Leu Ala Asn Ile Lys 
            500                 505                 510         


Ser Lys Val Val Tyr Glu Pro Ser Thr Phe Thr Lys Arg Ser Glu His 
        515                 520                 525             


Gln Tyr Arg Asp Ala Asp Lys Gln Glu Glu Glu Thr Glu Lys Gln Gln 
    530                 535                 540                 


Glu Tyr Gln Thr Leu Leu Asn Gln Arg Lys Arg Leu Leu Glu Gln His 
545                 550                 555                 560 


Leu Pro Lys Gly Val Lys Ile Asn Gln Ile Pro Glu Lys Val Leu Asp 
                565                 570                 575     


Phe Leu Met Asn Ile Ser Glu Pro Asn Glu Asn Lys Val Ile His Gln 
            580                 585                 590         


Lys Ile Lys Ser Ile Lys Asp Glu Ala Lys Thr Leu Leu Gln Arg Val 
        595                 600                 605             


Lys Asn Lys Gln Ala Ala Asn Glu Ile Pro Lys Leu Gly Glu Leu Ala 
    610                 615                 620                 


Thr Phe Leu Thr Arg Asp Ile Ile Asn Met Val Val Ser Glu Glu Leu 
625                 630                 635                 640 


Lys Lys Lys Ile Thr Ser Pro Tyr Ser Asn Lys Leu Gln Asn Lys Ile 
                645                 650                 655     


Ala Phe Phe Ser Leu Ser Lys Gln Glu Ile Ile Ser Leu Leu Ser Glu 
            660                 665                 670         


Leu Gln Leu Leu Asn Asn Glu Lys Gly His Val Phe Leu Ser Ser Arg 
        675                 680                 685             


Leu Ile Leu Glu Ser Asn Gly Leu Leu Ser Phe Tyr Lys Ser Tyr Leu 
    690                 695                 700                 


Glu Ala Lys Ile Ala Trp Ile Asp Lys Asn Leu Phe Leu Lys Gly Lys 
705                 710                 715                 720 


Lys Gly Gly Tyr Ile Ile Pro Glu Asn Lys Pro Val Pro Lys Thr Leu 
                725                 730                 735     


Gln Lys Ile Lys Gln Glu Val Ser Gln Phe Asp Phe Thr Gln Trp Leu 
            740                 745                 750         


Gln Asn Lys Ala Ala Met Pro Ile Asp Val Pro Asn Thr Ile Phe Asp 
        755                 760                 765             


Val Ser Leu Glu Asn Leu Leu Lys Thr Asn Leu Lys Lys Arg Gly Ile 
    770                 775                 780                 


Thr Val Lys Asp Thr Asp Lys Phe Ser Val Leu Leu Asn Lys Tyr Leu 
785                 790                 795                 800 


Asp Lys Asp Thr Gln Pro Phe Tyr Lys Tyr Gly Arg Val Tyr Lys Ile 
                805                 810                 815     


Gln Asp Glu Glu Glu Ser Val Gln Val Val Gly Lys Met Ser Lys Thr 
            820                 825                 830         


Leu Lys Lys Gln Tyr Gly Lys Phe Val Glu Glu Asn Glu Lys Val Ile 
        835                 840                 845             


Arg Phe Tyr Gln Ser Lys Asp Arg Val Ile Lys Leu Met Cys Asn Ala 
    850                 855                 860                 


Leu Leu Gln Ala Glu Asn Lys Thr Ala Leu Thr Asp Ser Phe Lys Leu 
865                 870                 875                 880 


Ala His Thr His Pro Asn Ser Lys Gln Asn Pro Leu Asp Thr Pro Met 
                885                 890                 895     


Arg Phe Glu Gln Lys Leu Phe Ser Asn Asp Lys Glu Thr Lys Val Leu 
            900                 905                 910         


Cys Thr Ile Tyr Ala Gln Asp Thr Glu Asn Gln Lys Asn Glu Ile Leu 
        915                 920                 925             


Ala Trp Asn Ser Leu Ser Glu Asp Asp Lys Lys Tyr Trp Leu Thr Leu 
    930                 935                 940                 


Thr Thr Lys Glu Ala Gln Lys Glu Trp Leu Ser Gly Lys Pro Glu Thr 
945                 950                 955                 960 


Glu Gln Glu Val Tyr His Gly Gln Lys Gly Tyr Gln Trp Thr Ile Lys 
                965                 970                 975     


Glu Val Gly Lys Phe Lys Arg Phe Val Lys Asp Arg Arg Ile Pro Ala 
            980                 985                 990         


Leu Val Asn Tyr Phe Glu Thr Thr  Lys Leu Pro Phe Ser  Leu Leu Glu 
        995                 1000                 1005             


Tyr Gln  Leu Lys Glu Tyr Asp  Arg Val Arg Glu Gln  Ile Phe Asp 
    1010                 1015                 1020             


Gly Val  Phe Lys Leu Glu Glu  Ala Ile Ser Gln Lys  Asp Leu Ala 
    1025                 1030                 1035             


Gly Ile  Trp Ala Leu Glu Gln  Glu Ala Arg Gly Arg  Lys Asn Tyr 
    1040                 1045                 1050             


His Gln  Val Gln Phe Asn Ile  Phe Glu Lys Tyr Leu  Gln Asn Thr 
    1055                 1060                 1065             


Leu Pro  Ser Tyr Asp Pro Ala  Ile Gly Val Ile Arg  Asn Lys Phe 
    1070                 1075                 1080             


Ser His  Asn Glu Phe Pro Asp  Leu Ile Gly Gln Gly  Ile Glu Lys 
    1085                 1090                 1095             


Ile Ser  Gln Ala Gln Ile Asp  Asp Tyr Gln Arg Asn  Lys His Leu 
    1100                 1105                 1110             


Lys Asp  Tyr Leu Ala His Ala  Gly Ile Ser Ile Ala  Gln Gln Ile 
    1115                 1120                 1125             


Leu Ala  Ile Phe Glu Gln Lys  Ile Asn Asp Thr Leu  Thr Gln Leu 
    1130                 1135                 1140             


Thr Thr  His Gly 
    1145         


<210>  1785
<211>  1147
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1785

Met Glu Ile Ala Thr Gln Gln Ser Glu Thr Gln Lys Lys Lys Arg Ser 
1               5                   10                  15      


Leu Asp Gln Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg 
            20                  25                  30          


His Asn Val Phe Leu Ile Val Asn His Leu Thr Asp Thr Phe Lys Glu 
        35                  40                  45              


Leu Asn Phe Lys Lys Leu Ala Asn Glu Glu Asp Ile Trp Lys Val Asp 
    50                  55                  60                  


Asn Ser Ser Asn Ile Leu Leu Asn Val Phe Asp Val Thr Gln Ser Lys 
65                  70                  75                  80  


Tyr Glu Asp Phe Arg Pro Arg Ile Phe His Tyr Leu Ile Lys Arg His 
                85                  90                  95      


His Leu Pro Leu Val Lys Ile Phe Asn Thr Glu Tyr Leu Gly Glu Asn 
            100                 105                 110         


Ile Leu Gln Asp Lys Ser Ile Asp Tyr Glu Arg Leu His Gln Phe Leu 
        115                 120                 125             


Cys Leu Ser Phe Lys Glu Leu Thr Glu Phe Arg Asn Ser Tyr Ser His 
    130                 135                 140                 


Ser Ile Ala Ile Asp Glu Asn Gly Asn Lys Val Gly Arg Lys Thr Thr 
145                 150                 155                 160 


Leu Ala Asn Asp Leu Val Pro Glu Val Asn Leu Leu Phe Lys Tyr Ala 
                165                 170                 175     


Pro Lys Tyr Ser Phe Leu Arg Asn His Gln Thr Leu Asn Glu Gly Asp 
            180                 185                 190         


Phe Gln His Leu Asp Asn Tyr Gln Leu Phe Ile Ala Asp Asn Gln Leu 
        195                 200                 205             


Thr His Gln Gly Arg Phe Phe Phe Ile Asn Leu Phe Leu Glu Arg Ser 
    210                 215                 220                 


Tyr Gly Ile Lys Phe Leu Lys Arg Phe Arg Gly Phe Lys Asn Glu Asn 
225                 230                 235                 240 


Thr Pro Pro Phe Lys Ala Thr Ile Gln Ser Phe Thr Thr Tyr Cys Leu 
                245                 250                 255     


Lys Val Pro Asp Ile Arg Leu Gly Asn Glu Asn Pro Lys Gln Ser Leu 
            260                 265                 270         


Leu Leu Asp Met Leu Thr Glu Leu Asn Lys Cys Pro Lys Glu Leu Phe 
        275                 280                 285             


Asn His Leu Thr Glu Asp Asp Lys Lys Glu Phe Glu Pro Asn Leu Asp 
    290                 295                 300                 


Glu Thr Ser Ser Thr Asn Val Leu Leu Asn Ser Thr Asn Tyr Glu Phe 
305                 310                 315                 320 


Phe Asp Thr Asp Glu Val Glu Glu Ala Ile Arg Glu Leu Thr Ala Gln 
                325                 330                 335     


Lys Arg His Ser Asp Arg Phe Pro Tyr Leu Ala Leu Arg Phe Leu Asp 
            340                 345                 350         


Glu Thr Met Ala Phe Ser Gln Leu Arg Phe Gln Leu Ser Leu Gly Lys 
        355                 360                 365             


Ile Ile Ile Lys Lys Pro Tyr Gln Lys Thr Ile Leu Gly Gln Pro Asn 
    370                 375                 380                 


Asp Arg Ile Ile Thr Lys Lys Leu Asn Val Phe Gly Arg Ile Ser Asp 
385                 390                 395                 400 


Phe Leu Asn Arg Glu Lys Glu Ile Ile Arg Ala Leu Ser Asn Asp Gln 
                405                 410                 415     


Asn Val Asp Phe Leu Glu Phe Glu Gln Phe Phe Pro His Tyr Asn Ile 
            420                 425                 430         


Asn Asn Asn Lys Ile Ala Phe Tyr Phe Leu Asn Asp Ser Asp Leu Thr 
        435                 440                 445             


Glu Glu Asn Leu Glu Ser Arg Leu Arg Asp Gln Glu Asn Arg Gln Pro 
    450                 455                 460                 


Thr Gly Phe Leu Ser Ile His Asp Leu Pro Lys Leu Val Leu Leu His 
465                 470                 475                 480 


Leu Leu Ala Pro Ser Glu Val Gln Lys Thr Leu Gln Arg Phe Ile Asn 
                485                 490                 495     


Asp Asn Asn Pro Ala Phe Phe Asp Leu Glu Leu Leu Ala Asn Ile Lys 
            500                 505                 510         


Ser Lys Val Val Tyr Glu Pro Ser Thr Phe Thr Lys Arg Ser Glu His 
        515                 520                 525             


Gln Tyr Arg Asp Ala Asp Lys Gln Glu Glu Glu Thr Glu Lys Gln Gln 
    530                 535                 540                 


Glu Tyr Gln Thr Leu Leu Asn Gln Arg Lys Arg Leu Leu Glu Gln His 
545                 550                 555                 560 


Leu Pro Lys Gly Val Lys Ile Asn Gln Ile Pro Glu Lys Val Leu Asp 
                565                 570                 575     


Phe Leu Met Asn Ile Ser Glu Pro Asn Glu Asn Lys Val Ile His Gln 
            580                 585                 590         


Lys Ile Lys Ser Ile Lys Asp Glu Ala Lys Thr Leu Leu Gln Arg Val 
        595                 600                 605             


Lys Asn Lys Gln Ala Ala Asn Glu Ile Pro Lys Leu Gly Glu Leu Ala 
    610                 615                 620                 


Thr Phe Leu Thr Arg Asp Ile Ile Asn Met Val Val Ser Glu Glu Leu 
625                 630                 635                 640 


Lys Lys Lys Ile Thr Ser Pro Tyr Ser Asn Lys Leu Gln Asn Lys Ile 
                645                 650                 655     


Ala Phe Phe Ser Leu Ser Lys Gln Glu Ile Ile Ser Leu Leu Ser Glu 
            660                 665                 670         


Leu Gln Leu Leu Asn Asn Glu Lys Gly His Val Phe Leu Ser Ser Arg 
        675                 680                 685             


Leu Ile Leu Glu Ser Asn Gly Leu Leu Ser Phe Tyr Lys Ser Tyr Leu 
    690                 695                 700                 


Glu Ala Lys Ile Ala Trp Ile Asp Lys Asn Leu Phe Leu Lys Gly Lys 
705                 710                 715                 720 


Lys Gly Gly Tyr Ile Ile Pro Glu Asn Lys Pro Val Pro Lys Thr Leu 
                725                 730                 735     


Gln Lys Ile Lys Gln Glu Val Ser Gln Phe Asp Phe Thr Gln Trp Leu 
            740                 745                 750         


Gln Asn Lys Ala Ala Met Pro Ile Asp Val Pro Asn Thr Ile Phe Asp 
        755                 760                 765             


Val Ser Leu Glu Asn Leu Leu Lys Thr Asn Leu Lys Lys Arg Gly Ile 
    770                 775                 780                 


Thr Val Lys Asp Thr Asp Lys Phe Ser Val Leu Leu Asn Lys Tyr Leu 
785                 790                 795                 800 


Asp Lys Asp Thr Gln Pro Phe Tyr Lys Tyr Gly Arg Val Tyr Lys Ile 
                805                 810                 815     


Gln Asp Glu Glu Glu Ser Val Gln Val Val Gly Lys Met Ser Lys Thr 
            820                 825                 830         


Leu Lys Lys Gln Tyr Gly Lys Phe Val Glu Glu Asn Glu Lys Val Ile 
        835                 840                 845             


Arg Phe Tyr Gln Ser Lys Asp Arg Val Ile Lys Leu Met Cys Asn Ala 
    850                 855                 860                 


Leu Leu Gln Ala Glu Asn Lys Thr Ala Leu Thr Asp Ser Phe Lys Leu 
865                 870                 875                 880 


Ala His Thr His Pro Asn Ser Lys Gln Asn Pro Leu Asp Thr Pro Met 
                885                 890                 895     


Arg Phe Glu Gln Lys Leu Phe Ser Asn Asp Lys Glu Thr Lys Val Leu 
            900                 905                 910         


Cys Thr Ile Tyr Ala Gln Asp Thr Glu Asn Gln Lys Asn Glu Ile Leu 
        915                 920                 925             


Ala Trp Asn Ser Leu Ser Glu Asp Asp Lys Lys Tyr Trp Leu Thr Leu 
    930                 935                 940                 


Thr Thr Lys Glu Ala Gln Lys Glu Trp Leu Ser Gly Lys Pro Glu Thr 
945                 950                 955                 960 


Glu Gln Glu Val Tyr His Gly Gln Lys Gly Tyr Gln Trp Thr Ile Lys 
                965                 970                 975     


Glu Val Gly Lys Phe Lys Arg Phe Val Lys Asp Arg Arg Ile Pro Ala 
            980                 985                 990         


Leu Val Asn Tyr Phe Glu Thr Thr  Lys Leu Pro Phe Ser  Leu Leu Glu 
        995                 1000                 1005             


Tyr Gln  Leu Lys Glu Tyr Asp  Arg Val Arg Glu Gln  Ile Phe Asp 
    1010                 1015                 1020             


Gly Val  Phe Lys Leu Glu Glu  Ala Ile Ser Gln Lys  Asp Leu Ala 
    1025                 1030                 1035             


Gly Ile  Trp Ala Leu Glu Gln  Glu Ala Arg Gly Arg  Lys Asn Tyr 
    1040                 1045                 1050             


His Gln  Val Gln Phe Asn Ile  Phe Glu Lys Tyr Leu  Gln Asn Thr 
    1055                 1060                 1065             


Leu Pro  Ser Tyr Asp Pro Ala  Ile Gly Val Ile Arg  Asn Lys Phe 
    1070                 1075                 1080             


Ser His  Asn Glu Phe Pro Asp  Leu Ile Gly Gln Gly  Ile Glu Lys 
    1085                 1090                 1095             


Ile Ser  Gln Ala Gln Ile Asp  Asp Tyr Gln Arg Asn  Lys His Leu 
    1100                 1105                 1110             


Lys Asp  Tyr Leu Ala His Ala  Gly Ile Ser Ile Ala  Gln Gln Ile 
    1115                 1120                 1125             


Leu Ala  Ile Phe Glu Gln Lys  Ile Asn Asp Thr Leu  Thr Gln Leu 
    1130                 1135                 1140             


Thr Thr  His Gly 
    1145         


<210>  1786
<211>  1147
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1786

Met Glu Ile Ala Thr Gln Gln Ser Glu Thr Gln Lys Lys Lys Arg Ser 
1               5                   10                  15      


Leu Asp Gln Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg 
            20                  25                  30          


His Asn Val Phe Leu Ile Val Asn His Leu Thr Asp Thr Phe Lys Glu 
        35                  40                  45              


Leu Asn Phe Lys Lys Leu Ala Asn Glu Glu Asp Ile Trp Lys Val Asp 
    50                  55                  60                  


Asn Ser Ser Asn Ile Leu Leu Asn Val Phe Asp Val Thr Gln Ser Lys 
65                  70                  75                  80  


Tyr Glu Asp Phe Arg Pro Arg Ile Phe His Tyr Leu Ile Lys Arg His 
                85                  90                  95      


His Leu Pro Leu Val Lys Ile Phe Asn Thr Glu Tyr Leu Gly Glu Asn 
            100                 105                 110         


Ile Leu Gln Asp Lys Ser Ile Asp Tyr Glu Arg Leu His Gln Phe Leu 
        115                 120                 125             


Cys Leu Ser Phe Lys Glu Leu Thr Glu Phe Arg Asn Ser Tyr Ser His 
    130                 135                 140                 


Ser Ile Ala Ile Asp Glu Asn Gly Asn Lys Val Gly Arg Lys Thr Thr 
145                 150                 155                 160 


Leu Ala Asn Asp Leu Val Pro Glu Val Asn Leu Leu Phe Lys Tyr Ala 
                165                 170                 175     


Pro Lys Tyr Ser Phe Leu Arg Asn His Gln Thr Leu Asn Glu Gly Asp 
            180                 185                 190         


Phe Gln His Leu Asp Asn Tyr Gln Leu Phe Ile Ala Asp Asn Gln Leu 
        195                 200                 205             


Thr His Gln Gly Arg Phe Phe Phe Ile Asn Leu Phe Leu Glu Arg Ser 
    210                 215                 220                 


Tyr Gly Ile Lys Phe Leu Lys Arg Phe Arg Gly Phe Lys Asn Glu Asn 
225                 230                 235                 240 


Thr Pro Pro Phe Lys Ala Thr Ile Gln Ser Phe Thr Thr Tyr Cys Leu 
                245                 250                 255     


Lys Val Pro Asp Ile Arg Leu Gly Asn Glu Asn Pro Lys Gln Ser Leu 
            260                 265                 270         


Leu Leu Asp Met Leu Thr Glu Leu Asn Lys Cys Pro Lys Glu Leu Phe 
        275                 280                 285             


Asn His Leu Thr Glu Asp Asp Lys Lys Glu Phe Glu Pro Asn Leu Asp 
    290                 295                 300                 


Glu Thr Ser Ser Thr Asn Val Leu Leu Asn Ser Thr Asn Tyr Glu Phe 
305                 310                 315                 320 


Phe Asp Thr Asp Glu Val Glu Glu Ala Ile Arg Glu Leu Thr Ala Gln 
                325                 330                 335     


Lys Arg His Ser Asp Arg Phe Pro Tyr Leu Ala Leu Arg Phe Leu Asp 
            340                 345                 350         


Glu Thr Met Ala Phe Ser Gln Leu Arg Phe Gln Leu Ser Leu Gly Lys 
        355                 360                 365             


Ile Ile Ile Lys Lys Pro Tyr Gln Lys Thr Ile Leu Gly Gln Pro Asn 
    370                 375                 380                 


Asp Arg Ile Ile Thr Lys Lys Leu Asn Val Phe Gly Arg Ile Ser Asp 
385                 390                 395                 400 


Phe Leu Asn Arg Glu Lys Glu Ile Ile Arg Ala Leu Ser Asn Asp Gln 
                405                 410                 415     


Asn Val Asp Phe Leu Glu Phe Glu Gln Phe Phe Pro His Tyr Asn Ile 
            420                 425                 430         


Asn Asn Asn Lys Ile Ala Phe Tyr Phe Leu Asn Asp Ser Asp Leu Thr 
        435                 440                 445             


Glu Glu Asn Leu Glu Ser Arg Leu Arg Asp Gln Glu Asn Arg Gln Pro 
    450                 455                 460                 


Thr Gly Phe Leu Ser Ile His Asp Leu Pro Lys Leu Val Leu Leu His 
465                 470                 475                 480 


Leu Leu Ala Pro Ser Glu Val Gln Lys Thr Leu Gln Arg Phe Ile Asn 
                485                 490                 495     


Asp Asn Asn Pro Ala Phe Phe Asp Leu Glu Leu Leu Ala Asn Ile Lys 
            500                 505                 510         


Ser Lys Val Val Tyr Glu Pro Ser Thr Phe Thr Lys Arg Ser Glu His 
        515                 520                 525             


Gln Tyr Arg Asp Ala Asp Lys Gln Glu Glu Glu Thr Glu Lys Gln Gln 
    530                 535                 540                 


Glu Tyr Gln Thr Leu Leu Asn Gln Arg Lys Arg Leu Leu Glu Gln His 
545                 550                 555                 560 


Leu Pro Lys Gly Val Lys Ile Asn Gln Ile Pro Glu Lys Val Leu Asp 
                565                 570                 575     


Phe Leu Met Asn Ile Ser Glu Pro Asn Glu Asn Lys Val Ile His Gln 
            580                 585                 590         


Lys Ile Lys Ser Ile Lys Asp Glu Ala Lys Thr Leu Leu Gln Arg Val 
        595                 600                 605             


Lys Asn Lys Gln Ala Ala Asn Glu Ile Pro Lys Leu Gly Glu Leu Ala 
    610                 615                 620                 


Thr Phe Leu Thr Arg Asp Ile Ile Asn Met Val Val Ser Glu Glu Leu 
625                 630                 635                 640 


Lys Lys Lys Ile Thr Ser Pro Tyr Ser Asn Lys Leu Gln Asn Lys Ile 
                645                 650                 655     


Ala Phe Phe Ser Leu Ser Lys Gln Glu Ile Ile Ser Leu Leu Ser Glu 
            660                 665                 670         


Leu Gln Leu Leu Asn Asn Glu Lys Gly His Val Phe Leu Ser Ser Arg 
        675                 680                 685             


Leu Ile Leu Glu Ser Asn Gly Leu Leu Ser Phe Tyr Lys Ser Tyr Leu 
    690                 695                 700                 


Glu Ala Lys Ile Ala Trp Ile Asp Lys Asn Leu Phe Leu Lys Gly Lys 
705                 710                 715                 720 


Lys Gly Gly Tyr Ile Ile Pro Glu Asn Lys Pro Val Pro Lys Thr Leu 
                725                 730                 735     


Gln Lys Ile Lys Gln Glu Val Ser Gln Phe Asp Phe Thr Gln Trp Leu 
            740                 745                 750         


Gln Asn Lys Ala Ala Met Pro Ile Asp Val Pro Asn Thr Ile Phe Asp 
        755                 760                 765             


Val Ser Leu Glu Asn Leu Leu Lys Thr Asn Leu Lys Lys Arg Gly Ile 
    770                 775                 780                 


Thr Val Lys Asp Thr Asp Lys Phe Ser Val Leu Leu Asn Lys Tyr Leu 
785                 790                 795                 800 


Asp Lys Asp Thr Gln Pro Phe Tyr Lys Tyr Gly Arg Val Tyr Lys Ile 
                805                 810                 815     


Gln Asp Glu Glu Glu Ser Val Gln Val Val Gly Lys Met Ser Lys Thr 
            820                 825                 830         


Leu Lys Lys Gln Tyr Gly Lys Phe Val Glu Glu Asn Glu Lys Val Ile 
        835                 840                 845             


Arg Phe Tyr Gln Ser Lys Asp Arg Val Ile Lys Leu Met Cys Asn Ala 
    850                 855                 860                 


Leu Leu Gln Ala Glu Asn Lys Thr Ala Leu Thr Asp Ser Phe Lys Leu 
865                 870                 875                 880 


Ala His Thr His Pro Asn Ser Lys Gln Asn Pro Leu Asp Thr Pro Met 
                885                 890                 895     


Arg Phe Glu Gln Lys Leu Phe Ser Asn Asp Lys Glu Thr Lys Val Leu 
            900                 905                 910         


Cys Thr Ile Tyr Ala Gln Asp Thr Glu Asn Gln Lys Asn Glu Ile Leu 
        915                 920                 925             


Ala Trp Asn Ser Leu Ser Glu Asp Asp Lys Lys Tyr Trp Leu Thr Leu 
    930                 935                 940                 


Thr Thr Lys Glu Ala Gln Lys Glu Trp Leu Ser Gly Lys Pro Glu Thr 
945                 950                 955                 960 


Glu Gln Glu Val Tyr His Gly Gln Lys Gly Tyr Gln Trp Thr Ile Lys 
                965                 970                 975     


Glu Val Gly Lys Phe Lys Arg Phe Val Lys Asp Arg Arg Ile Pro Ala 
            980                 985                 990         


Leu Val Asn Tyr Phe Glu Thr Thr  Lys Leu Pro Phe Ser  Leu Leu Glu 
        995                 1000                 1005             


Tyr Gln  Leu Lys Glu Tyr Asp  Arg Val Arg Glu Gln  Ile Phe Asp 
    1010                 1015                 1020             


Gly Val  Phe Lys Leu Glu Glu  Ala Ile Ser Gln Lys  Asp Leu Ala 
    1025                 1030                 1035             


Gly Ile  Trp Ala Leu Glu Gln  Glu Ala Arg Gly Arg  Lys Asn Tyr 
    1040                 1045                 1050             


His Gln  Val Gln Phe Asn Ile  Phe Glu Lys Tyr Leu  Gln Asn Thr 
    1055                 1060                 1065             


Leu Pro  Ser Tyr Asp Pro Ala  Ile Gly Val Ile Arg  Asn Lys Phe 
    1070                 1075                 1080             


Ser His  Asn Glu Phe Pro Asp  Leu Ile Gly Gln Gly  Ile Glu Lys 
    1085                 1090                 1095             


Ile Ser  Gln Ala Gln Ile Asp  Asp Tyr Gln Arg Asn  Lys His Leu 
    1100                 1105                 1110             


Lys Asp  Tyr Leu Ala His Ala  Gly Ile Ser Ile Ala  Gln Gln Ile 
    1115                 1120                 1125             


Leu Ala  Ile Phe Glu Gln Lys  Ile Asn Asp Thr Leu  Thr Gln Leu 
    1130                 1135                 1140             


Thr Thr  His Gly 
    1145         


<210>  1787
<211>  1147
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1787

Met Glu Ile Ala Thr Gln Gln Ser Glu Thr Gln Lys Lys Lys Arg Ser 
1               5                   10                  15      


Leu Asp Gln Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg 
            20                  25                  30          


His Asn Val Phe Leu Ile Val Asn His Leu Thr Asp Thr Phe Lys Glu 
        35                  40                  45              


Leu Asn Phe Lys Lys Leu Ala Asn Glu Glu Asp Ile Trp Lys Val Asp 
    50                  55                  60                  


Asn Ser Ser Asn Ile Leu Leu Asn Val Phe Asp Val Thr Gln Ser Lys 
65                  70                  75                  80  


Tyr Glu Asp Phe Arg Pro Arg Ile Phe His Tyr Leu Ile Lys Arg His 
                85                  90                  95      


His Leu Pro Leu Val Lys Ile Phe Asn Thr Glu Tyr Leu Gly Glu Asn 
            100                 105                 110         


Ile Leu Gln Asp Lys Ser Ile Asp Tyr Glu Arg Leu His Gln Phe Leu 
        115                 120                 125             


Cys Leu Ser Phe Lys Glu Leu Thr Glu Phe Arg Asn Ser Tyr Ser His 
    130                 135                 140                 


Ser Ile Ala Ile Asp Glu Asn Gly Asn Lys Val Gly Arg Lys Thr Thr 
145                 150                 155                 160 


Leu Ala Asn Asp Leu Val Pro Glu Val Asn Leu Leu Phe Lys Tyr Ala 
                165                 170                 175     


Pro Lys Tyr Ser Phe Leu Arg Asn His Gln Thr Leu Asn Glu Gly Asp 
            180                 185                 190         


Phe Gln His Leu Asp Asn Tyr Gln Leu Phe Ile Ala Asp Asn Gln Leu 
        195                 200                 205             


Thr His Gln Gly Arg Phe Phe Phe Ile Asn Leu Phe Leu Glu Arg Ser 
    210                 215                 220                 


Tyr Gly Ile Lys Phe Leu Lys Arg Phe Arg Gly Phe Lys Asn Glu Asn 
225                 230                 235                 240 


Thr Pro Pro Phe Lys Ala Thr Ile Gln Ser Phe Thr Thr Tyr Cys Leu 
                245                 250                 255     


Lys Val Pro Asp Ile Arg Leu Gly Asn Glu Asn Pro Lys Gln Ser Leu 
            260                 265                 270         


Leu Leu Asp Met Leu Thr Glu Leu Asn Lys Cys Pro Lys Glu Leu Phe 
        275                 280                 285             


Asn His Leu Thr Glu Asp Asp Lys Lys Glu Phe Glu Pro Asn Leu Asp 
    290                 295                 300                 


Glu Thr Ser Ser Thr Asn Val Leu Leu Asn Ser Thr Asn Tyr Glu Phe 
305                 310                 315                 320 


Phe Asp Thr Asp Glu Val Glu Glu Ala Ile Arg Glu Leu Thr Ala Gln 
                325                 330                 335     


Lys Arg His Ser Asp Arg Phe Pro Tyr Leu Ala Leu Arg Phe Leu Asp 
            340                 345                 350         


Glu Thr Met Ala Phe Ser Gln Leu Arg Phe Gln Leu Ser Leu Gly Lys 
        355                 360                 365             


Ile Ile Ile Lys Lys Pro Tyr Gln Lys Thr Ile Leu Gly Gln Pro Asn 
    370                 375                 380                 


Asp Arg Ile Ile Thr Lys Lys Leu Asn Val Phe Gly Arg Ile Ser Asp 
385                 390                 395                 400 


Phe Leu Asn Arg Glu Lys Glu Ile Ile Arg Ala Leu Ser Asn Asp Gln 
                405                 410                 415     


Asn Val Asp Phe Leu Glu Phe Glu Gln Phe Phe Pro His Tyr Asn Ile 
            420                 425                 430         


Asn Asn Asn Lys Ile Ala Phe Tyr Phe Leu Asn Asp Ser Asp Leu Thr 
        435                 440                 445             


Glu Glu Asn Leu Glu Ser Arg Leu Arg Asp Gln Glu Asn Arg Gln Pro 
    450                 455                 460                 


Thr Gly Phe Leu Ser Ile His Asp Leu Pro Lys Leu Val Leu Leu His 
465                 470                 475                 480 


Leu Leu Ala Pro Ser Glu Val Gln Lys Thr Leu Gln Arg Phe Ile Asn 
                485                 490                 495     


Asp Asn Asn Pro Ala Phe Phe Asp Leu Glu Leu Leu Ala Asn Ile Lys 
            500                 505                 510         


Ser Lys Val Val Tyr Glu Pro Ser Thr Phe Thr Lys Arg Ser Glu His 
        515                 520                 525             


Gln Tyr Arg Asp Ala Asp Lys Gln Glu Glu Glu Thr Glu Lys Gln Gln 
    530                 535                 540                 


Glu Tyr Gln Thr Leu Leu Asn Gln Arg Lys Arg Leu Leu Glu Gln His 
545                 550                 555                 560 


Leu Pro Lys Gly Val Lys Ile Asn Gln Ile Pro Glu Lys Val Leu Asp 
                565                 570                 575     


Phe Leu Met Asn Ile Ser Glu Pro Asn Glu Asn Lys Val Ile His Gln 
            580                 585                 590         


Lys Ile Lys Ser Ile Lys Asp Glu Ala Lys Thr Leu Leu Gln Arg Val 
        595                 600                 605             


Lys Asn Lys Gln Ala Ala Asn Glu Ile Pro Lys Leu Gly Glu Leu Ala 
    610                 615                 620                 


Thr Phe Leu Thr Arg Asp Ile Ile Asn Met Val Val Ser Glu Glu Leu 
625                 630                 635                 640 


Lys Lys Lys Ile Thr Ser Pro Tyr Ser Asn Lys Leu Gln Asn Lys Ile 
                645                 650                 655     


Ala Phe Phe Ser Leu Ser Lys Gln Glu Ile Ile Ser Leu Leu Ser Glu 
            660                 665                 670         


Leu Gln Leu Leu Asn Asn Glu Lys Gly His Val Phe Leu Ser Ser Arg 
        675                 680                 685             


Leu Ile Leu Glu Ser Asn Gly Leu Leu Ser Phe Tyr Lys Ser Tyr Leu 
    690                 695                 700                 


Glu Ala Lys Ile Ala Trp Ile Asp Lys Asn Leu Phe Leu Lys Gly Lys 
705                 710                 715                 720 


Lys Gly Gly Tyr Ile Ile Pro Glu Asn Lys Pro Val Pro Lys Thr Leu 
                725                 730                 735     


Gln Lys Ile Lys Gln Glu Val Ser Gln Phe Asp Phe Thr Gln Trp Leu 
            740                 745                 750         


Gln Asn Lys Ala Ala Met Pro Ile Asp Val Pro Asn Thr Ile Phe Asp 
        755                 760                 765             


Val Ser Leu Glu Asn Leu Leu Lys Thr Asn Leu Lys Lys Arg Gly Ile 
    770                 775                 780                 


Thr Val Lys Asp Thr Asp Lys Phe Ser Val Leu Leu Asn Lys Tyr Leu 
785                 790                 795                 800 


Asp Lys Asp Thr Gln Pro Phe Tyr Lys Tyr Gly Arg Val Tyr Lys Ile 
                805                 810                 815     


Gln Asp Glu Glu Glu Ser Val Gln Val Val Gly Lys Met Ser Lys Thr 
            820                 825                 830         


Leu Lys Lys Gln Tyr Gly Lys Phe Val Glu Glu Asn Glu Lys Val Ile 
        835                 840                 845             


Arg Phe Tyr Gln Ser Lys Asp Arg Val Ile Lys Leu Met Cys Asn Ala 
    850                 855                 860                 


Leu Leu Gln Ala Glu Asn Lys Thr Ala Leu Thr Asp Ser Phe Lys Leu 
865                 870                 875                 880 


Ala His Thr His Pro Asn Ser Lys Gln Asn Pro Leu Asp Thr Pro Met 
                885                 890                 895     


Arg Phe Glu Gln Lys Leu Phe Ser Asn Asp Lys Glu Thr Lys Val Leu 
            900                 905                 910         


Cys Thr Ile Tyr Ala Gln Asp Thr Glu Asn Gln Lys Asn Glu Ile Leu 
        915                 920                 925             


Ala Trp Asn Ser Leu Ser Glu Asp Asp Lys Lys Tyr Trp Leu Thr Leu 
    930                 935                 940                 


Thr Thr Lys Glu Ala Gln Lys Glu Trp Leu Ser Gly Lys Pro Glu Thr 
945                 950                 955                 960 


Glu Gln Glu Val Tyr His Gly Gln Lys Gly Tyr Gln Trp Thr Ile Lys 
                965                 970                 975     


Glu Val Gly Lys Phe Lys Arg Phe Val Lys Asp Arg Arg Ile Pro Ala 
            980                 985                 990         


Leu Val Asn Tyr Phe Glu Thr Thr  Lys Leu Pro Phe Ser  Leu Leu Glu 
        995                 1000                 1005             


Tyr Gln  Leu Lys Glu Tyr Asp  Arg Val Arg Glu Gln  Ile Phe Asp 
    1010                 1015                 1020             


Gly Val  Phe Lys Leu Glu Glu  Ala Ile Ser Gln Lys  Asp Leu Ala 
    1025                 1030                 1035             


Gly Ile  Trp Ala Leu Glu Gln  Glu Ala Arg Gly Arg  Lys Asn Tyr 
    1040                 1045                 1050             


His Gln  Val Gln Phe Asn Ile  Phe Glu Lys Tyr Leu  Gln Asn Thr 
    1055                 1060                 1065             


Leu Pro  Ser Tyr Asp Pro Ala  Ile Gly Val Ile Arg  Asn Lys Phe 
    1070                 1075                 1080             


Ser His  Asn Glu Phe Pro Asp  Leu Ile Gly Gln Gly  Ile Glu Lys 
    1085                 1090                 1095             


Ile Ser  Gln Ala Gln Ile Asp  Asp Tyr Gln Arg Asn  Lys His Leu 
    1100                 1105                 1110             


Lys Asp  Tyr Leu Ala His Ala  Gly Ile Ser Ile Ala  Gln Gln Ile 
    1115                 1120                 1125             


Leu Ala  Ile Phe Glu Gln Lys  Ile Asn Asp Thr Leu  Thr Gln Leu 
    1130                 1135                 1140             


Thr Thr  His Gly 
    1145         


<210>  1788
<211>  1084
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1788

Met Asn Pro Thr Asn Pro Pro Thr Met Ser Lys Gly Glu Tyr Arg Gln 
1               5                   10                  15      


Phe Asp Asn Pro Lys Asp Lys Ala Phe Tyr Ala Ala Tyr Leu Asn Thr 
            20                  25                  30          


Ala Lys Gln Asn Ile Phe Ile Ile Leu Arg Asp Leu Ser Glu Arg Leu 
        35                  40                  45              


Gly Leu Gly Phe Glu Asp Asn Asp Asp Arg Met Phe Ser Ala Met Phe 
    50                  55                  60                  


Trp Ser Lys Leu Ser Val Asn Asp Glu Glu Phe Ser Gln Arg Ile Ile 
65                  70                  75                  80  


Asp His Leu His His His Phe Arg Phe Leu Lys Ser Val Thr Leu Asn 
                85                  90                  95      


Tyr Ala Arg Tyr Arg Thr Asp Asn Leu Leu Ala Thr Ala Leu Pro Glu 
            100                 105                 110         


Asp Tyr His Phe Val Leu Lys Lys Trp Ile Asp Gln Leu Ile Ala Tyr 
        115                 120                 125             


Arg Asn Tyr Tyr Thr His Ala Ala His Asp Pro Ile Cys Met Asp Pro 
    130                 135                 140                 


Gln Ile Ile Tyr Asp Met Arg Gly Leu Tyr Tyr Ala Glu Trp Lys Glu 
145                 150                 155                 160 


Phe Lys Lys Gln Lys Asn Leu Thr Asp Thr Asp Val Ala His Leu His 
                165                 170                 175     


Gly Leu Asp Lys Lys Gly His Glu Lys Pro Gly Phe Leu Tyr Ala Phe 
            180                 185                 190         


Arg Asn Asp Lys Gly Leu Thr Glu Lys Gly Leu Leu Tyr Phe Thr Cys 
        195                 200                 205             


Leu Trp Leu Glu Lys Arg Ser Gly Gln Glu Leu Leu Lys Lys His Tyr 
    210                 215                 220                 


Gly Phe Lys Asp Ser Arg Glu Arg Ser Gln Lys Ala Thr Leu Glu Lys 
225                 230                 235                 240 


Phe Thr Arg Trp Ser Ala Tyr Val Pro Lys Pro Lys Ile Thr Ser Asp 
                245                 250                 255     


His Ser Thr Gln Ser Leu Phe Leu Asp Met Val Asn Glu Leu Gln Arg 
            260                 265                 270         


Cys Pro Lys Ala Leu Phe Asp Gln Leu Gln Lys Thr His Gln Gln Ile 
        275                 280                 285             


Phe Glu Arg Ala Ala Glu Asp Glu Thr Glu Glu Leu Asp Gly Tyr Glu 
    290                 295                 300                 


Asn Lys Pro Ile Leu Leu Arg Lys Gln Asn Arg Phe Phe Tyr Phe Ala 
305                 310                 315                 320 


Leu Arg Tyr Leu Asp Arg Ser Phe Glu His Leu Lys Phe His Ile Asp 
                325                 330                 335     


Leu Gly Asn Gly Cys Phe Asn Ser Tyr Asp Gln Arg Ile Ala Glu Lys 
            340                 345                 350         


Asp Trp Lys Arg Gln Trp Met His Arg Ile Thr Gly Phe Gly Asn Leu 
        355                 360                 365             


Thr Asp Phe Thr Asn Arg Val Pro Glu Ser Trp Lys His Leu Gln Ala 
    370                 375                 380                 


Arg Pro Gly Glu Gln Ala Thr Arg Lys Thr Tyr Ile Thr Glu Thr Thr 
385                 390                 395                 400 


Pro His Tyr His Phe Asp Pro Ala Ser Glu Val Met Thr Ile Gly Met 
                405                 410                 415     


Lys Trp Val Glu His Tyr Asp Pro Ala Ala Ala Trp Pro Leu Val Lys 
            420                 425                 430         


Thr Asp Ile Asn Gly Glu Ile Leu Lys Pro Lys Asn Glu Ala Pro Asp 
        435                 440                 445             


Phe Trp Leu Ser Leu Tyr Glu Leu Pro Ala Met Val Phe Tyr Gln Trp 
    450                 455                 460                 


Leu His Leu Thr Ala Pro Thr Arg Val Leu Leu Thr Ala Glu Ala Ile 
465                 470                 475                 480 


Ile Lys Gln His Gln Lys Asn Ile Gly Leu Phe Phe Ser Glu Leu Lys 
                485                 490                 495     


Thr Leu Ala His Ala Asn Ser Ile Arg Arg Glu Glu Leu Asp Thr Leu 
            500                 505                 510         


Leu Ala Lys His His Leu Glu Ile Gly Trp Val Pro Lys Pro Ile Ile 
        515                 520                 525             


Lys Cys Ile Leu Asp Gln Ser Gln Pro Thr Ser His Met Lys Ala Thr 
    530                 535                 540                 


Asn Arg Leu Lys Glu Met Met Arg Glu Asn Ser Glu Leu Leu Asp Arg 
545                 550                 555                 560 


Leu Ser Arg Arg Lys Glu His His Gln Ala Arg Thr Ser Ser Lys Asp 
                565                 570                 575     


Tyr Leu Pro Met Lys Ser Gly His Met Ala Asp Phe Leu Ala Arg Asp 
            580                 585                 590         


Met Ile Gln Leu Gln Pro Ala Ile Asn Gln Asp Gln Gly Lys Ala Asn 
        595                 600                 605             


Ser Thr Glu Phe Gln Val Leu Gln Ser Gln Leu Ala Phe Phe Gly Arg 
    610                 615                 620                 


Tyr Arg Asp Gln Leu Gln Glu Thr Phe Ala Leu Cys Asn Leu Thr Ala 
625                 630                 635                 640 


Ala Ser Asn Pro His Pro Phe Leu His Lys Val Glu Glu Arg Lys Cys 
                645                 650                 655     


Arg Gly Ile Phe Glu Tyr Tyr Gln Ser Tyr Leu Gln Glu Arg Gly Arg 
            660                 665                 670         


Phe Leu Gln Glu Cys Ala Glu Ser Pro Asn Pro Glu Gln Leu His Phe 
        675                 680                 685             


Leu Ser Ile Lys Pro Gln Arg Asp Leu Asp Lys Ile Ile Glu Gly Gln 
    690                 695                 700                 


Leu Ser Ala Val Met Asn Leu Pro Arg Gly Leu Phe Lys Gln Pro Ile 
705                 710                 715                 720 


Ile Asn Ala Leu Lys Ser Lys Glu Thr Thr Arg Pro Leu Ala Ile Lys 
                725                 730                 735     


Leu Gln Ala Met Asp Arg Cys Asn Val Ala Tyr Ile Ile Gln Ser Tyr 
            740                 745                 750         


Phe His Glu Leu Gln Gln Asp Gln Ser Gln Pro Tyr Tyr Asn Tyr Pro 
        755                 760                 765             


Arg Glu Tyr Lys Leu Leu Asn Lys Leu Tyr Asp Pro Arg Pro Asn Pro 
    770                 775                 780                 


Leu Lys Gly Lys Pro Pro His Leu Ser Tyr Ser Pro Gln Gln Leu Thr 
785                 790                 795                 800 


Gln Leu Gln Glu Asp Ile Ala Leu Arg Leu Lys Ile Ser Ile Glu Lys 
                805                 810                 815     


Asp Ile Thr Lys Asn Lys Arg Lys Gly Ala Glu Arg Ile Lys Glu Lys 
            820                 825                 830         


Trp His Lys Leu Phe Lys Val Phe Thr Glu Asn Glu Lys Gln Ile Arg 
        835                 840                 845             


Leu Tyr Gln Asn Gly Asp Gln Val Leu Trp Leu Met Val Gln Gln Leu 
    850                 855                 860                 


Tyr Gln Asn Leu Glu Glu Asp Asn Ala Lys His Gln Thr Pro Leu Thr 
865                 870                 875                 880 


Met Glu Gly Asp Phe Leu Leu Gly Glu Ile Thr Pro Glu Thr Gln Lys 
                885                 890                 895     


Gly Ile Leu Asn Met Thr Val Arg Val Ser Val Pro Ile Lys Thr Arg 
            900                 905                 910         


Ser Gly His Ser Lys Gln Ile Ile Asn Pro Thr Leu Lys Ile Lys Asn 
        915                 920                 925             


Tyr Gly Asn Phe Arg Ala Leu Leu Lys Asp Arg Arg Val Ala Gly Met 
    930                 935                 940                 


Leu Ser Phe Val Ser Ala Asp Glu Ile Ala Glu Ser Ala Ile Arg Arg 
945                 950                 955                 960 


Glu Leu Glu Trp Phe Glu Gln Val Arg Val Pro Ile Leu Gln His Ile 
                965                 970                 975     


His Val Leu Glu Lys Val Val Ile Glu Lys Tyr Thr Leu Gln Lys Asn 
            980                 985                 990         


Lys Asp Gly Tyr Ile Ser His Asp  Glu Ile Leu Gly Tyr  Val Pro Gly 
        995                 1000                 1005             


Leu Ser  Glu Gln Met Lys Asn  Leu Leu Asp Glu Phe  Arg Asn Met 
    1010                 1015                 1020             


Val Cys  His Ser Gln Tyr Pro  Glu Leu Glu Val Phe  Lys Gly Leu 
    1025                 1030                 1035             


Ile Ala  Gly Ala Asp Phe Asn  Asp Leu Gln His Tyr  Lys Lys Glu 
    1040                 1045                 1050             


Asn Pro  Ala Ile Lys Glu Lys  Ser Ile Ala Ser Gln  Leu Leu Lys 
    1055                 1060                 1065             


Leu Ala  Asn His Asn Tyr His  Glu Thr Ile Gln Ala  Val Lys Lys 
    1070                 1075                 1080             


Ala 
    


<210>  1789
<211>  1141
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1789

Met Glu Asp Asp Lys Lys Thr Thr Glu Ser Thr Asn Met Leu Asp Asn 
1               5                   10                  15      


Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val Tyr 
            20                  25                  30          


Ile Thr Val Asn His Ile Asn Lys Val Leu Glu Leu Lys Asn Lys Lys 
        35                  40                  45              


Asp Gln Asp Ile Ile Ile Asp Asn Asp Gln Asp Ile Leu Ala Ile Lys 
    50                  55                  60                  


Thr His Trp Glu Lys Val Asn Gly Asp Leu Asn Lys Thr Glu Arg Leu 
65                  70                  75                  80  


Arg Glu Leu Met Thr Lys His Phe Pro Phe Leu Glu Thr Ala Ile Tyr 
                85                  90                  95      


Thr Lys Asn Lys Glu Asp Lys Glu Glu Val Lys Gln Glu Lys Gln Ala 
            100                 105                 110         


Lys Ala Gln Ser Phe Asp Ser Leu Lys His Cys Leu Phe Leu Phe Leu 
        115                 120                 125             


Glu Lys Leu Gln Glu Ala Arg Asn Tyr Tyr Ser His Tyr Lys Tyr Ser 
    130                 135                 140                 


Glu Ser Thr Lys Glu Pro Met Leu Glu Lys Glu Leu Leu Lys Lys Met 
145                 150                 155                 160 


Tyr Asn Ile Phe Asp Asp Asn Ile Gln Leu Val Ile Lys Asp Tyr Gln 
                165                 170                 175     


His Asn Lys Asp Ile Asn Pro Asp Glu Asp Phe Lys His Leu Asp Arg 
            180                 185                 190         


Thr Glu Glu Glu Phe Asn Tyr Tyr Phe Thr Arg Asn Lys Lys Gly Asn 
        195                 200                 205             


Ile Thr Ala Ser Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys 
    210                 215                 220                 


Lys Asp Ala Ile Trp Met Gln Gln Lys Leu Arg Gly Phe Lys Asp Asn 
225                 230                 235                 240 


Arg Glu Ser Lys Lys Lys Met Thr His Glu Val Phe Cys Arg Arg Arg 
                245                 250                 255     


Met Leu Leu Pro Lys Leu Arg Leu Glu Ser Thr Gln Thr Gln Asp Trp 
            260                 265                 270         


Ile Leu Leu Asp Met Leu Asn Glu Leu Ile Arg Cys Pro Lys Ser Leu 
        275                 280                 285             


Tyr Glu Arg Leu Gln Gly Glu Asp Arg Glu Lys Phe Lys Val Pro Phe 
    290                 295                 300                 


Asp Pro Ala Asp Glu Asp Tyr Asp Ala Glu Gln Glu Pro Phe Lys Asn 
305                 310                 315                 320 


Thr Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr 
                325                 330                 335     


Phe Asp Tyr Asn Glu Ile Phe Thr Asn Leu Arg Phe Gln Ile Asp Leu 
            340                 345                 350         


Gly Thr Tyr His Phe Ser Ile Tyr Lys Lys Leu Ile Gly Gly Gln Lys 
        355                 360                 365             


Glu Asp Arg His Leu Thr His Lys Leu Tyr Gly Phe Glu Arg Ile Gln 
    370                 375                 380                 


Glu Phe Ala Lys Gln Asn Arg Thr Asp Glu Trp Lys Ala Ile Val Lys 
385                 390                 395                 400 


Asp Leu Asp Thr Tyr Glu Thr Ser Asn Glu Arg Tyr Ile Ser Glu Thr 
                405                 410                 415     


Ile Pro His Tyr His Leu Glu Asn Gln Lys Ile Gly Ile Arg Phe Arg 
            420                 425                 430         


Asn Asp Asn Asp Glu Ile Trp Pro Ser Leu Lys Thr Asn Gly Glu Asn 
        435                 440                 445             


Asn Glu Lys Arg Lys Tyr Lys Leu Asp Lys Gln Tyr Gln Ala Glu Ala 
    450                 455                 460                 


Phe Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu 
465                 470                 475                 480 


Leu Lys Met Glu Asn Thr Asp Asn Gly Lys Glu Asn Asn Glu Val Gly 
                485                 490                 495     


Thr Lys Lys Lys Arg Asn Lys Asn Asn Glu Gln Glu Lys His Lys Ile 
            500                 505                 510         


Glu Glu Ile Ile Glu Asn Lys Ile Lys Asp Ile Tyr Ala Leu Tyr Asp 
        515                 520                 525             


Ala Phe Ala Asn Gly Glu Ile Asn Ser Glu Glu Glu Leu Lys Glu Tyr 
    530                 535                 540                 


Leu Lys Gly Lys Asp Ile Glu Ile Val His Leu Pro Lys Gln Met Ile 
545                 550                 555                 560 


Ala Ile Leu Glu Ser Lys Pro Lys Asp Met Val Lys Glu Ala Lys Arg 
                565                 570                 575     


Lys Gln Lys Glu Met Val Lys Asp Thr Lys Lys Leu Leu Ala Ala Leu 
            580                 585                 590         


Glu Lys Gln Thr Gln Gly Glu Ile Glu Asp Gly Gly Arg Asn Ile Arg 
        595                 600                 605             


Leu Leu Lys Ser Gly Glu Ile Ala Arg Trp Leu Val Asn Asp Met Met 
    610                 615                 620                 


Arg Phe Gln Pro Val Gln Lys Asp Asn Glu Gly Asn Pro Leu Asn Asn 
625                 630                 635                 640 


Ser Lys Ala Asn Ser Thr Glu Tyr Gln Met Leu Gln Arg Ser Leu Ala 
                645                 650                 655     


Leu Tyr Asn Lys Glu Glu Lys Pro Thr Arg Tyr Phe Arg Gln Val Asn 
            660                 665                 670         


Leu Ile Asn Ser Ser Asn Pro His Pro Phe Leu Lys Trp Thr Lys Trp 
        675                 680                 685             


Glu Glu Cys Asn Asn Ile Leu Ser Phe Tyr Arg Ser Tyr Leu Thr Lys 
    690                 695                 700                 


Lys Ile Glu Phe Leu Asn Lys Leu Lys Pro Glu Glu Trp Lys Lys Asn 
705                 710                 715                 720 


Gln Tyr Phe Leu Lys Leu Lys Glu Pro Lys Thr Asn Arg Glu Thr Leu 
                725                 730                 735     


Val Gln Gly Trp Lys Asn Gly Phe Asn Leu Pro Arg Gly Ile Phe Thr 
            740                 745                 750         


Glu Pro Ile Arg Glu Trp Phe Lys Arg His Gln Asn Asp Ser Lys Glu 
        755                 760                 765             


Tyr Glu Lys Val Glu Ala Leu Asp Arg Val Gly Leu Val Ala Lys Val 
    770                 775                 780                 


Ile Pro Leu Phe Phe Lys Glu Glu Tyr Phe Lys Glu Asp Ala Gln Lys 
785                 790                 795                 800 


Glu Ile Asn Asn Cys Val Gln Pro Phe Tyr Ser Phe Pro Tyr Asn Val 
                805                 810                 815     


Gly Asn Ile His Lys Pro Asp Glu Lys Asp Phe Leu Pro Ser Glu Glu 
            820                 825                 830         


Arg Lys Lys Arg Trp Gly Asp Lys Lys Tyr Lys Phe Lys Gly Tyr Lys 
        835                 840                 845             


Ala Lys Val Lys Ser Lys Lys Leu Thr Asp Lys Glu Lys Glu Glu Tyr 
    850                 855                 860                 


Arg Ser Tyr Leu Glu Phe Gln Ser Trp Asn Lys Phe Glu Arg Glu Leu 
865                 870                 875                 880 


Arg Leu Val Arg Asn Gln Asp Ile Val Thr Trp Leu Leu Cys Thr Glu 
                885                 890                 895     


Leu Ile Asp Lys Leu Lys Val Glu Gly Leu Asn Val Glu Glu Leu Gln 
            900                 905                 910         


Lys Leu Arg Leu Lys Asp Ile Asp Thr Asp Thr Ala Lys Gln Glu Lys 
        915                 920                 925             


Asn Asn Ile Leu Asn Arg Ile Met Pro Met Gln Leu Pro Val Thr Val 
    930                 935                 940                 


Tyr Glu Ile Asp Asp Ser His Asn Ile Val Lys Asp Lys Pro Leu His 
945                 950                 955                 960 


Thr Val Tyr Ile Glu Glu Thr Lys Thr Lys Leu Leu Lys Gln Gly Asn 
                965                 970                 975     


Phe Lys Ala Leu Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe 
            980                 985                 990         


Val Asp Thr Ser Ser Lys Ala Glu  Leu Lys Asp Lys Pro  Ile Ser Lys 
        995                 1000                 1005             


Ser Val  Val Glu Tyr Glu Leu  Gly Glu Tyr Gln Asn  Ala Arg Ile 
    1010                 1015                 1020             


Glu Thr  Ile Lys Asp Met Leu  Leu Leu Glu Glu Thr  Leu Ile Lys 
    1025                 1030                 1035             


Lys Tyr  Lys Thr Leu Pro Thr  Asn Lys Phe Ser Ala  Met Leu Asn 
    1040                 1045                 1050             


Gly Trp  Leu Glu Gly Lys Asp  Glu Ala Asp Lys Ala  Arg Phe Gln 
    1055                 1060                 1065             


Asn Asp  Val Lys Leu Leu Val  Ala Val Arg Asn Ala  Phe Ser His 
    1070                 1075                 1080             


Asn Gln  Tyr Pro Met Arg Asn  Arg Ile Ala Phe Ala  Asn Ile Asn 
    1085                 1090                 1095             


Pro Phe  Ser Leu Ser Ser Ala  Asn Thr Ser Glu Glu  Lys Lys Leu 
    1100                 1105                 1110             


Asp Ile  Ala Asn Gln Leu Lys  Asp Lys Thr His Lys  Thr Ile Glu 
    1115                 1120                 1125             


Lys Ile  Ile Glu Ile Glu Lys  Pro Ile Glu Thr Lys  Glu 
    1130                 1135                 1140     


<210>  1790
<211>  1119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1790

Met Thr Ser Ile Gln Ile Ser Arg Gly Asn Thr Asn Leu Thr Arg Lys 
1               5                   10                  15      


Tyr Gln Leu Arg Glu Leu Ile Leu Lys His Phe Pro Phe Ile Gln Pro 
            20                  25                  30          


Ala Ile Ile Gly Ala Gln Thr Lys Glu Arg Thr Thr Ile Asp Lys Asp 
        35                  40                  45              


Lys Arg Ser Thr Ser Thr Ser Asn Asp Ser Leu Lys Gln Thr Gly Glu 
    50                  55                  60                  


Gly Asp Ile Asn Asp Pro Leu Ser Leu Ser Asn Val Lys Ser Met Phe 
65                  70                  75                  80  


Phe Ser Leu Leu Gln Met Leu Glu Gln Leu Arg Asn Tyr Tyr Ser His 
                85                  90                  95      


Val Lys His Ser Lys Ser Ala Thr Met Pro Asn Phe Asp Glu Asp Leu 
            100                 105                 110         


Leu Asn Trp Met Arg Tyr Ile Phe Ile Asp Ser Val Asn Lys Val Lys 
        115                 120                 125             


Glu Asp Tyr Ser Ser Asn Ser Val Ile Asp Pro Asn Thr Cys Phe Ser 
    130                 135                 140                 


His Leu Ile Tyr Lys Asp Lys Gln Gly Lys Ile Lys Pro Cys Arg Tyr 
145                 150                 155                 160 


Pro Phe Thr Ser Lys Asp Gly Ser Ile Asn Ala Phe Gly Leu Leu Phe 
                165                 170                 175     


Phe Val Ser Leu Phe Leu Glu Lys Gln Asp Ser Ile Trp Met Gln Lys 
            180                 185                 190         


Lys Ile Pro Gly Phe Lys Lys Ala Ser Glu Asn Tyr Met Lys Met Thr 
        195                 200                 205             


Asn Glu Val Phe Cys Arg Asn His Ile Leu Leu Pro Lys Ile Arg Leu 
    210                 215                 220                 


Glu Thr Val Tyr Asp Lys Asp Trp Met Leu Leu Asp Met Leu Asn Glu 
225                 230                 235                 240 


Val Val Arg Cys Pro Leu Ser Leu Tyr Lys Arg Leu Thr Pro Ala Asp 
                245                 250                 255     


Gln Asn Lys Phe Lys Val Pro Glu Lys Ser Ser Asp Asn Ala Asn Arg 
            260                 265                 270         


Gln Glu Asp Asp Asn Pro Phe Ser Arg Ile Leu Val Arg His Gln Asn 
        275                 280                 285             


Arg Phe Pro Tyr Phe Ala Leu Arg Phe Phe Asp Leu Asn Glu Val Phe 
    290                 295                 300                 


Thr Thr Leu Arg Phe Gln Ile Asn Leu Gly Cys Tyr His Phe Ala Ile 
305                 310                 315                 320 


Cys Lys Lys Gln Ile Gly Asp Lys Lys Glu Val His His Leu Thr Arg 
                325                 330                 335     


Thr Leu Tyr Gly Phe Ser Arg Leu Gln Asn Phe Thr Gln Asn Thr Arg 
            340                 345                 350         


Pro Glu Glu Trp Asn Thr Leu Val Lys Thr Thr Glu Pro Ser Ser Gly 
        355                 360                 365             


Asn Asp Gly Lys Thr Val Gln Gly Val Pro Leu Pro Tyr Ile Ser Tyr 
    370                 375                 380                 


Thr Ile Pro His Tyr Gln Ile Glu Asn Glu Lys Ile Gly Ile Lys Ile 
385                 390                 395                 400 


Phe Asp Gly Asp Thr Ala Val Asp Thr Asp Ile Trp Pro Ser Val Ser 
                405                 410                 415     


Thr Glu Lys Gln Leu Asn Lys Pro Asp Lys Tyr Thr Leu Thr Pro Gly 
            420                 425                 430         


Phe Lys Ala Asp Val Phe Leu Ser Val His Glu Leu Leu Pro Met Met 
        435                 440                 445             


Phe Tyr Tyr Gln Leu Leu Leu Cys Glu Gly Met Leu Lys Thr Asp Ala 
    450                 455                 460                 


Gly Asn Ala Val Glu Lys Val Leu Ile Asp Thr Arg Asn Ala Ile Phe 
465                 470                 475                 480 


Asn Leu Tyr Asp Ala Phe Val Gln Glu Lys Ile Asn Thr Ile Thr Asp 
                485                 490                 495     


Leu Glu Asn Tyr Leu Gln Asp Lys Pro Ile Leu Ile Gly His Leu Pro 
            500                 505                 510         


Lys Gln Met Ile Asp Leu Leu Lys Gly His Gln Arg Asp Met Gln Lys 
        515                 520                 525             


Ala Ala Glu Gln Lys Lys Lys Met Leu Ile Lys Asp Thr Glu Arg Arg 
    530                 535                 540                 


Leu Lys Ser Leu Asn Lys Gln Leu Asn Gln Lys Pro Asn Val Ala Ala 
545                 550                 555                 560 


Lys Asn Thr Gly Thr Leu Leu Arg Asn Gly Gln Ile Ala Asp Trp Leu 
                565                 570                 575     


Val Asn Asp Met Met Arg Phe Gln Pro Val Lys Arg Asp Lys Glu Gly 
            580                 585                 590         


Asn Pro Ile Asn Cys Ser Lys Ala Asn Ser Thr Glu Tyr Gln Met Leu 
        595                 600                 605             


Gln Arg Ala Phe Ala Phe Tyr Thr Thr Asp Ser Trp Arg Leu Pro Arg 
    610                 615                 620                 


Tyr Phe Glu Gln Leu His Leu Ile His Ser Asp Asn Ser His Leu Phe 
625                 630                 635                 640 


Leu Ser His Phe Glu Tyr Asp Lys Gln Pro Asn Leu Ile Ala Phe Tyr 
                645                 650                 655     


Ala Ala Tyr Leu Lys Ala Lys Leu Asp Phe Leu Asn Glu Leu Arg Pro 
            660                 665                 670         


Glu Asn Trp Ala Ser Asn Asn Tyr Phe Leu Leu Leu Arg Ala Pro Lys 
        675                 680                 685             


Asn Asp Arg Gln Lys Leu Ala Glu Gly Trp Lys Asn Gly Phe Asn Leu 
    690                 695                 700                 


Pro Arg Gly Leu Phe Thr Glu Lys Ile Lys Thr Trp Phe Ser Glu His 
705                 710                 715                 720 


Lys Glu Ile Val Asp Leu Ser Asn Asp Asp Leu Phe Lys Ser Arg Val 
                725                 730                 735     


Gly Gln Val Ala Arg Leu Ile Pro Ala Phe Phe Asp Lys Lys Phe Thr 
            740                 745                 750         


Asp His Ser Gln Pro Phe Tyr Arg Tyr Asp Phe Asn Val Gly Asn Val 
        755                 760                 765             


Ser Lys Pro Thr Glu Ala Asn Tyr Leu Ser Lys Glu Lys Arg Glu Lys 
    770                 775                 780                 


Leu Phe Lys Ser Tyr Gln Asn Lys Phe Lys Asn Asn Ile Pro Ala Glu 
785                 790                 795                 800 


Lys Thr Lys Glu Tyr Arg Glu Tyr Lys Asn Phe Ser Ser Trp Lys Lys 
                805                 810                 815     


Phe Glu Arg Glu Leu Arg Leu Ile Lys Asn Gln Asp Ile Leu Thr Trp 
            820                 825                 830         


Leu Met Cys Lys Asn Leu Phe Asp Glu Gln Lys Asp Lys Glu Val Asn 
        835                 840                 845             


Ile Ser Asp Ile Lys Leu Asp Ser Leu Gln Thr Asn Thr Ser Thr Lys 
    850                 855                 860                 


Gly Ser Leu Asn Ala Leu Ala Gln Val Val Pro Met Val Leu Ala Ile 
865                 870                 875                 880 


His Ile Gly Asn Ser Glu Ser Lys Asn Glu Thr Gly Ala Asn Glu Glu 
                885                 890                 895     


Glu Asn Lys Arg Pro Thr Val Tyr Ile Lys Glu Arg Gly Thr Lys Arg 
            900                 905                 910         


Ser Lys Trp Glu Asn Leu Lys Thr Pro Leu Ala Asp Tyr Ile Asp Asn 
        915                 920                 925             


Ser Glu Ser Lys Asn Glu Thr Gly Thr Asn Glu Glu Glu Asn Lys Gly 
    930                 935                 940                 


Pro Thr Val Tyr Ile Lys Glu Glu Gly Thr Lys Leu Leu Lys Trp Gly 
945                 950                 955                 960 


Asn Phe Lys Thr Leu Leu Ala Asp Arg Arg Ile Lys Gly Leu Phe Ser 
                965                 970                 975     


Tyr Ile Glu His Asp Asp Ile Asn Leu Glu Lys Tyr Pro Leu Thr Lys 
            980                 985                 990         


Tyr Gln Val Asp Ser Glu Leu Asp  Leu Tyr Gln Lys Tyr  Arg Ile Asp 
        995                 1000                 1005             


Ile Phe  Lys Gln Thr Leu Asp  Leu Glu Ala Gln Leu  Leu Asp Lys 
    1010                 1015                 1020             


Tyr Ser  Asp Leu Asn Thr Asp  Asn Phe Asn Gln Met  Leu Ser Gly 
    1025                 1030                 1035             


Trp Ser  Glu Lys Glu Gly Ile  Pro Arg Asp Ile Lys  Glu Asp Thr 
    1040                 1045                 1050             


Asp Phe  Leu Lys Asp Val Arg  Asn Ala Phe Ser His  Asn Gln Tyr 
    1055                 1060                 1065             


Pro Asp  Ser Lys Lys Ile Ala  Phe Ser Arg Ile Arg  Lys Phe Asn 
    1070                 1075                 1080             


Pro Lys  Glu Leu Ile Leu Glu  Glu Lys Lys Gly Leu  Ser Ile Ala 
    1085                 1090                 1095             


Lys Gln  Met Tyr Glu Glu Val  Glu Lys Val Val Asn  Arg Ile Lys 
    1100                 1105                 1110             


Gly Ile  Glu Leu Phe Asp 
    1115                 


<210>  1791
<211>  1098
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1791

Met Glu Asn Asp Lys Arg Leu Glu Glu Ser Ala Cys Tyr Thr Leu Asn 
1               5                   10                  15      


Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val 
            20                  25                  30          


Tyr Ile Thr Val Asn His Ile Asn Lys Thr Leu Gly Glu Gly Glu Ile 
        35                  40                  45              


Asn Arg Asp Gly Tyr Glu Thr Thr Leu Glu Asn Thr Trp Asn Glu Ile 
    50                  55                  60                  


Lys Asp Ile Asn Lys Lys Ala Arg Leu Arg Glu Leu Ile Ile Lys His 
65                  70                  75                  80  


Phe Pro Phe Leu Glu Ala Ala Thr Tyr Gln Gln Arg Ser Thr Asp Ser 
                85                  90                  95      


Thr Lys Gln Lys Glu Glu Lys Gln Ala Glu Ala Gln Ser Leu Glu Ser 
            100                 105                 110         


Leu Lys His Cys Leu Phe Pro Phe Leu Lys Lys Leu Gln Lys Ser Arg 
        115                 120                 125             


Asp His Tyr Ser His Tyr Lys His Ser Lys Ser Leu Glu Arg Pro Lys 
    130                 135                 140                 


Phe Glu Glu Asp Leu Gln Lys Lys Met Tyr Asn Ile Phe Asp Val Ser 
145                 150                 155                 160 


Ile Arg Leu Val Lys Glu Asp Tyr Lys His Asn Thr Asp Ile Asn Leu 
                165                 170                 175     


Lys Glu Asp Phe Lys His Leu Asn Arg Thr Gly Lys Phe Lys Tyr Ser 
            180                 185                 190         


Phe Ala Asp Asn Lys Gly Asn Ile Thr Glu Ser Gly Leu Leu Phe Phe 
        195                 200                 205             


Ile Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Met Gln Lys Lys 
    210                 215                 220                 


Leu Lys Gly Phe Lys Asp Ser Arg Glu Lys Tyr Gln Lys Met Thr Asn 
225                 230                 235                 240 


Glu Val Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu Glu 
                245                 250                 255     


Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu Asn Glu Leu 
            260                 265                 270         


Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Arg Glu Lys Glu Arg 
        275                 280                 285             


Lys Glu Phe Lys Val Pro Ile Glu Ile Ala Asp Glu Asp Tyr Asp Ala 
    290                 295                 300                 


Glu Gln Glu Pro Phe Arg Asn Thr Leu Val Arg His Gln Asp Arg Phe 
305                 310                 315                 320 


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Tyr Asn Glu Ile Phe Thr Asn 
                325                 330                 335     


Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile Tyr Lys 
            340                 345                 350         


Lys Leu Ile Gly Gly Asn Lys Glu Asp Arg His Leu Thr His Lys Leu 
        355                 360                 365             


Tyr Gly Phe Glu Arg Ile Gln Glu Phe Ala Lys Gln Asn Arg Pro Asp 
    370                 375                 380                 


Glu Trp Lys Ala Leu Val Lys Asp Leu Asp Thr Phe Asn Lys Glu Glu 
385                 390                 395                 400 


Glu Lys Pro Tyr Ile Ser Glu Thr Thr Pro His Tyr His Leu Glu Asn 
                405                 410                 415     


Glu Lys Ile Gly Ile Val Phe Lys Asn His Asn Ile Trp Pro Ser Thr 
            420                 425                 430         


Lys Thr Glu Leu Thr Asn Asn Asn Arg Lys Lys Tyr Asn Leu Gly Ala 
        435                 440                 445             


Ser Ile Lys Ala Glu Ala Phe Leu Ser Val His Glu Leu Leu Pro Met 
    450                 455                 460                 


Met Phe Tyr Tyr Leu Leu Leu Lys Thr Lys Asn Thr His Asn Gly Asn 
465                 470                 475                 480 


Glu Val Glu Ala Lys Lys Lys Gly Thr Lys Asn Lys Lys Gln Glu Lys 
                485                 490                 495     


His Lys Ile Glu Ala Ile Ile Glu Ser Lys Ile Lys Asp Ile Tyr Asn 
            500                 505                 510         


Leu Tyr Asp Ala Phe Ala Asn Gly Glu Ile Asn Ser Ile Glu Glu Leu 
        515                 520                 525             


Glu Glu His Cys Lys Gly Lys Asp Ile Glu Ile Gly His Leu Pro Lys 
    530                 535                 540                 


Gln Met Ile Ala Ile Leu Lys Asp Glu His Lys Asp Met Ala Lys Lys 
545                 550                 555                 560 


Ala Glu Thr Lys Gln Glu Lys Met Ile Leu Ala Thr Glu Asn Arg Leu 
                565                 570                 575     


Lys Thr Leu Asp Lys Lys Leu Lys Gly Lys Ile Arg Asn Gly Lys Arg 
            580                 585                 590         


Cys Asn Ser Ala Leu Lys Ser Gly Glu Ile Ala Ser Trp Leu Val Asn 
        595                 600                 605             


Asp Met Met Arg Phe Gln Pro Val Gln Arg Asp Glu Glu Gly Lys Pro 
    610                 615                 620                 


Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln Leu Leu Gln Arg 
625                 630                 635                 640 


Thr Leu Ala Phe Phe Gly Ser Glu His Glu Arg Leu Asp Pro Tyr Phe 
                645                 650                 655     


Lys Gln Met Asn Leu Ile Gly Asp Asn Asn Pro His Pro Phe Leu Lys 
            660                 665                 670         


Glu Thr Lys Trp Glu Glu Cys Asn Asn Ile Leu Ser Phe Tyr Arg Ser 
        675                 680                 685             


Tyr Leu Glu Ala Lys Lys Asn Phe Leu Glu Ser Leu Lys Pro Glu Asp 
    690                 695                 700                 


Trp Lys Lys Asn Gln Tyr Phe Leu Met Leu Lys Glu Pro Lys Asn Asn 
705                 710                 715                 720 


Arg Glu Thr Leu Val Gln Gly Trp Lys Asn Gly Phe Asn Leu Pro Arg 
                725                 730                 735     


Gly Ile Phe Thr Glu Pro Ile Arg Lys Trp Phe Met Glu His Arg Lys 
            740                 745                 750         


Lys Ile Lys Ala Asp Glu Leu Lys Arg Val Gly Phe Val Ala Lys Val 
        755                 760                 765             


Ile Pro Leu Phe Phe Ser Lys Glu Tyr Lys Asp Gly Val Gln Pro Phe 
    770                 775                 780                 


Tyr Asn Tyr Pro Phe Asn Val Gly Asn Ile Asn Lys Pro Glu Glu Lys 
785                 790                 795                 800 


Asp Phe Leu Asp Tyr Glu Lys Arg Lys Lys Leu Trp Asp Lys Lys Gln 
                805                 810                 815     


Ala Lys Phe Lys Gly Lys Thr Asp Lys Glu Lys Arg Glu Asp Pro Ser 
            820                 825                 830         


Tyr Pro Asp Phe Lys Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu 
        835                 840                 845             


Val Arg Asn Gln Asp Ile Val Thr Trp Met Leu Cys Met Glu Leu Phe 
    850                 855                 860                 


Glu Glu Gln Lys Val Asp Gly Leu Asn Thr Gly Gln Ile His Leu Lys 
865                 870                 875                 880 


Asp Ile Val Thr Asn Val Asp Glu Glu Gly Asn Asn Asn Ile Leu Asn 
                885                 890                 895     


Gln Ile Lys Pro Met Gln Leu Pro Ile Thr Val Tyr Asp Lys Glu Asn 
            900                 905                 910         


Ser Pro Lys Arg Lys Pro Leu His Thr Val Tyr Ile Glu Glu Thr Gly 
        915                 920                 925             


Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys Asp Arg 
    930                 935                 940                 


Arg Leu Asn Gly Leu Phe Ser Phe Val Lys Thr Ser Ser Glu Ala Glu 
945                 950                 955                 960 


Ser Lys Ser Lys Pro Ile Ser Lys Ser Arg Val Glu Tyr Glu Leu Gly 
                965                 970                 975     


Ala Tyr Gln Lys Ala Arg Ile Asp Ile Ile Lys Asp Met Leu Ala Leu 
            980                 985                 990         


Glu Lys Thr Leu Ile Asp Asn Asp  Glu Asn Leu Pro Thr  Asn Lys Phe 
        995                 1000                 1005             


Ser Asp  Met Leu Lys Ser Trp  Leu Lys Gly Lys Gly  Glu Ala Asn 
    1010                 1015                 1020             


Lys Val  Arg Phe Gln Asn Asp  Val Asp Leu Leu Val  Ala Val Arg 
    1025                 1030                 1035             


Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met Tyr Asn  Ser Glu Val 
    1040                 1045                 1050             


Phe Lys  Gly Met Lys Leu Leu  Ser Leu Ser Ser Asp  Ile Pro Glu 
    1055                 1060                 1065             


Lys Glu  Gly Leu Gly Ile Ala  Lys Gln Leu Lys Asp  Lys Ile Lys 
    1070                 1075                 1080             


Glu Thr  Ile Glu Arg Ile Ile  Glu Ile Glu Lys Glu  Ile Arg Asn 
    1085                 1090                 1095             


<210>  1792
<211>  1207
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1792

Met Glu Asn Lys Thr Ser Leu Gly Asn Asn Ile Tyr Tyr Asn Pro Phe 
1               5                   10                  15      


Lys Pro Gln Asp Lys Ser Tyr Phe Ala Gly Tyr Phe Asn Ala Ala Met 
            20                  25                  30          


Glu Asn Ile Asp Ser Val Phe Arg Glu Leu Gly Lys Arg Leu Lys Gly 
        35                  40                  45              


Lys Gly Tyr Thr Ser Glu Asn Phe Phe Asp Ala Ile Phe Lys Glu Asn 
    50                  55                  60                  


Ile Ser Leu Val Glu Tyr Glu Arg Tyr Val Lys Leu Leu Ser Asp Tyr 
65                  70                  75                  80  


Phe Pro Met Ala Arg Leu Leu Asp Lys Lys Glu Val Pro Ile Lys Glu 
                85                  90                  95      


Arg Lys Glu Asn Phe Lys Lys Asn Phe Lys Gly Ile Ile Lys Ala Val 
            100                 105                 110         


Arg Asp Leu Arg Asn Phe Tyr Thr His Lys Glu His Arg Glu Val Glu 
        115                 120                 125             


Ile Thr Asp Glu Ile Phe Gly Val Leu Asp Glu Met Leu Lys Ser Thr 
    130                 135                 140                 


Val Leu Thr Val Lys Lys Lys Lys Val Lys Thr Asp Lys Thr Lys Glu 
145                 150                 155                 160 


Ile Leu Lys Lys Ser Ile Glu Lys Gln Leu Asp Ile Leu Cys Gln Lys 
                165                 170                 175     


Lys Leu Glu Tyr Leu Arg Asp Thr Ala Arg Lys Ile Glu Glu Lys Arg 
            180                 185                 190         


Arg Asn Gln Arg Glu Arg Gly Glu Lys Lys Leu Val Ala Pro Phe Lys 
        195                 200                 205             


Tyr Ser Asp Lys Arg Asp Asp Leu Ile Ala Ala Ile Tyr Asn Asp Ala 
    210                 215                 220                 


Phe Asp Val Tyr Ile Asp Lys Lys Lys Asp Ser Leu Lys Glu Ser Ser 
225                 230                 235                 240 


Lys Ala Lys Tyr Asn Thr Glu Ser Tyr Pro Gln Gln Glu Lys Gly Asp 
                245                 250                 255     


Leu Glu Ile Pro Ile Ser Lys Asn Gly Val Val Phe Leu Leu Ser Leu 
            260                 265                 270         


Phe Leu Thr Lys Gln Glu Ile His Ala Phe Lys Ser Lys Ile Ala Gly 
        275                 280                 285             


Phe Lys Ala Thr Val Ile Asp Glu Ala Thr Val Ser Glu Ala Thr Val 
    290                 295                 300                 


Ser His Arg Lys Asn Ser Ile Cys Phe Met Ala Thr His Glu Ile Phe 
305                 310                 315                 320 


Ser His Leu Ala Tyr Lys Lys Leu Lys Arg Lys Val Arg Thr Ala Glu 
                325                 330                 335     


Ile Asn Tyr Gly Glu Ala Glu Asn Ala Glu Gln Leu Ser Val Tyr Ala 
            340                 345                 350         


Lys Glu Thr Leu Met Met Gln Met Leu Asp Glu Leu Ser Lys Val Pro 
        355                 360                 365             


Asp Val Val Tyr Gln Asn Leu Ser Glu Asp Val Gln Lys Thr Phe Ile 
    370                 375                 380                 


Glu Asp Trp Asn Glu Tyr Leu Lys Glu Asn Asn Gly Asp Val Arg Thr 
385                 390                 395                 400 


Met Glu Glu Glu Gln Val Ile His Pro Val Ile Arg Lys Arg Tyr Glu 
                405                 410                 415     


Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe Ala Gln 
            420                 425                 430         


Phe Pro Thr Leu Arg Phe Gln Val His Leu Gly Asn Tyr Leu His Asp 
        435                 440                 445             


Ser Arg Pro Lys Glu Asn Leu Ile Ser Asp Arg Arg Ile Lys Glu Lys 
    450                 455                 460                 


Ile Thr Val Phe Gly Arg Leu Ser Glu Leu Glu His Lys Lys Ala Leu 
465                 470                 475                 480 


Phe Ile Lys Asn Thr Glu Thr Asn Glu Asp Arg Glu His Tyr Trp Glu 
                485                 490                 495     


Ile Phe Pro Asn Pro Asn Tyr Asp Phe Pro Lys Glu Asn Ile Ser Val 
            500                 505                 510         


Asn Asp Lys Asp Phe Pro Ile Ala Gly Ser Ile Leu Asp Arg Glu Lys 
        515                 520                 525             


Gln Pro Val Ala Gly Lys Ile Gly Ile Lys Val Lys Leu Leu Asn Gln 
    530                 535                 540                 


Gln Tyr Val Ser Glu Val Asp Lys Ala Val Lys Ala His Gln Leu Lys 
545                 550                 555                 560 


Gln Arg Lys Ala Lys Lys Pro Ser Ile Gln Asn Ile Ile Glu Glu Ile 
                565                 570                 575     


Val Pro Ile Asn Glu Ser Asn Pro Lys Glu Ala Ile Val Phe Gly Gly 
            580                 585                 590         


Gln Pro Thr Ala Tyr Leu Ser Met Asn Asp Ile His Ser Ile Leu Tyr 
        595                 600                 605             


Glu Phe Leu Ile Lys Gly Thr Ser Gly Glu Ala Leu Glu Lys Lys Ile 
    610                 615                 620                 


Val Gly Lys Ile Gln Ala Gln Ile Gln Gln Ile Ile Asp Lys Asp Thr 
625                 630                 635                 640 


Asn Ala Lys Ile Leu Lys Pro Tyr Gln Asp Gly Asn Ser Thr Ala Ile 
                645                 650                 655     


Asp Lys Glu Lys Leu Ile Lys Asp Leu Lys Gln Glu Gln Asn Ile Leu 
            660                 665                 670         


Gln Lys Leu Lys Asn Glu Gln Thr Ala Arg Glu Lys Glu Tyr Asn Asp 
        675                 680                 685             


Phe Ile Ala Tyr Gln Asp Lys Asn Arg Glu Ile Asn Lys Val Arg Asp 
    690                 695                 700                 


Arg Asn His Lys Gln Tyr Leu Lys Asp Asn Leu Lys Arg Lys Tyr Pro 
705                 710                 715                 720 


Glu Val Pro Thr Arg Lys Glu Ile Leu Tyr Tyr Gln Glu Lys Gly Lys 
                725                 730                 735     


Val Ala Val Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Thr Asp 
            740                 745                 750         


Phe Lys Asn Glu Trp Lys Gly Glu Gln His Ser Leu Leu Gln Lys Ser 
        755                 760                 765             


Leu Ala Tyr Tyr Glu Gln Cys Lys Glu Glu Leu Lys Asn Leu Leu Pro 
    770                 775                 780                 


Glu Lys Val Phe Gln His Leu Pro Phe Lys Leu Gly Gly Tyr Phe Gln 
785                 790                 795                 800 


Gln Lys Tyr Leu Tyr Gln Phe Tyr Thr Cys Tyr Leu Asp Lys Arg Leu 
                805                 810                 815     


Glu Tyr Ile Ser Gly Leu Val Gln Gln Ala Glu Ser Phe Lys Ser Glu 
            820                 825                 830         


Asn Lys Val Phe Lys Lys Val Glu Asn Glu Cys Phe Lys Phe Leu Lys 
        835                 840                 845             


Lys Gln Asn Tyr Thr His Lys Glu Leu Asp Ala Arg Val Gln Ser Ile 
    850                 855                 860                 


Leu Gly Tyr Pro Ile Phe Leu Glu Arg Gly Phe Met Asp Glu Lys Pro 
865                 870                 875                 880 


Thr Ile Ile Lys Gly Lys Thr Phe Lys Gly Asn Glu Ser Leu Phe Ala 
                885                 890                 895     


Asp Trp Phe Arg Tyr Tyr Lys Glu Tyr Gln Asn Phe Gln Thr Phe Tyr 
            900                 905                 910         


Asn Ala Lys Gln Tyr Pro Leu Val Glu Leu Glu Glu Lys Gln Ala Asp 
        915                 920                 925             


Arg Lys Arg Lys Thr Lys Ile Tyr Gln Gln Lys Lys Asn Asp Val Phe 
    930                 935                 940                 


Thr Leu Leu Met Ala Lys His Ile Phe Lys Ser Val Phe Lys Gln Asp 
945                 950                 955                 960 


Ser Ile Asp Arg Phe Ser Leu Glu Asp Leu Tyr Gln Ser Arg Glu Glu 
                965                 970                 975     


Arg Leu Glu Asn Gln Glu Lys Ala Lys Gln Thr Gly Glu Arg Asn Thr 
            980                 985                 990         


Asn Tyr Ile Trp Asn Lys Thr Val  Asp Leu Lys Leu Cys  Asp Gly Lys 
        995                 1000                 1005             


Ile Thr  Val Glu Asn Val Lys  Leu Lys Asn Val Gly  Asp Phe Ile 
    1010                 1015                 1020             


Lys Tyr  Glu Tyr Asp Gln Arg  Val Gln Ala Phe Leu  Lys Tyr Glu 
    1025                 1030                 1035             


Glu Asn  Ile Lys Trp Gln Ala  Phe Leu Ile Lys Glu  Ser Lys Glu 
    1040                 1045                 1050             


Glu Glu  Asn Tyr Pro Tyr Val  Val Glu Arg Glu Ile  Glu Gln Tyr 
    1055                 1060                 1065             


Glu Lys  Val Arg Arg Glu Glu  Leu Leu Lys Glu Val  His Leu Ile 
    1070                 1075                 1080             


Glu Glu  Tyr Ile Leu Glu Lys  Val Lys Asp Lys Glu  Ile Leu Lys 
    1085                 1090                 1095             


Lys Gly  Asp Asn Gln Asn Phe  Lys Tyr Tyr Ile Leu  Asn Gly Leu 
    1100                 1105                 1110             


Leu Lys  Gln Leu Lys Asn Glu  Asn Val Asp Gly Tyr  Lys Val Phe 
    1115                 1120                 1125             


Asn Leu  Asn Thr Glu Pro Glu  Asp Val Asn Ile Asn  Gln Leu Lys 
    1130                 1135                 1140             


Gln Glu  Ala Thr Asp Leu Glu  Gln Lys Ala Phe Val  Leu Thr Tyr 
    1145                 1150                 1155             


Ile Arg  Asn Lys Phe Ala His  Asn Gln Leu Pro Lys  Lys Glu Phe 
    1160                 1165                 1170             


Trp Asp  Tyr Cys Gln Glu Lys  Tyr Gly Lys Ile Glu  Lys Glu Lys 
    1175                 1180                 1185             


Thr Tyr  Ala Glu Tyr Phe Ala  Glu Val Phe Lys Arg  Glu Lys Glu 
    1190                 1195                 1200             


Ala Leu  Ile Lys 
    1205         


<210>  1793
<211>  1008
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1793

Met Asp Thr Pro Asn Phe Ser Glu Arg Ile Pro Val Ser Leu Gln Ser 
1               5                   10                  15      


His Pro Tyr Tyr Phe Ala His Tyr Leu Asn Met Ala Arg His Asn Ala 
            20                  25                  30          


Tyr Val Ile Leu Glu Tyr Val Asn Arg Glu Leu Ile Lys Pro Gly Lys 
        35                  40                  45              


Asn Leu Asp Glu Asp Asn Leu Ile Gln Ser Thr Val Leu Lys Asp Gly 
    50                  55                  60                  


Tyr Phe Asp Arg Lys Pro Asp Glu Leu Ser His Arg Asn Arg Leu Leu 
65                  70                  75                  80  


Val Gln His Phe Pro Phe Leu Arg Glu Ala Glu Asn Glu Gly Ala Arg 
                85                  90                  95      


Thr Cys Asn Pro Val Ser Tyr Lys Leu Lys Thr Ala Leu Ala Ala Leu 
            100                 105                 110         


Asn Gln Trp Arg Asn Asn Ala Ser His Tyr Pro Leu Asn Gln Asn His 
        115                 120                 125             


Glu Lys Asp Phe Asp Leu Gln Pro Phe Phe Ser Phe Ala Ile Glu Ala 
    130                 135                 140                 


Cys Lys Lys Arg Met Arg Glu Val Phe Gln Pro Asp Asp Phe Tyr Leu 
145                 150                 155                 160 


Leu Glu Thr Asn Glu Lys Gln Phe Tyr Thr Leu His Asn Glu Asn Gly 
                165                 170                 175     


Phe Thr Glu Lys Gly Leu Tyr Cys Phe Ile Cys Phe Phe Leu Glu Lys 
            180                 185                 190         


Lys Tyr Ala Phe Gln Phe Leu Ala Gly Ile Lys Gly Phe Lys Asn Thr 
        195                 200                 205             


Thr Asp Asn Lys Phe Arg Ala Thr Leu Glu Thr Phe Thr Glu His Cys 
    210                 215                 220                 


Cys Arg Leu Pro Lys Pro Lys Leu Asp Ser Ser Asp Ile Lys Leu Asp 
225                 230                 235                 240 


Met Leu Gly Glu Leu Ser Arg Cys Pro Ala Pro Leu Phe Asp Leu Leu 
                245                 250                 255     


Asp Ile Glu Glu Arg Lys Lys Phe Ile Arg Glu Pro Glu Glu Val Lys 
            260                 265                 270         


Pro Asp Glu Ser Gly Asp Arg Glu Glu Val Gln Gln Val Leu Met Lys 
        275                 280                 285             


Arg Tyr Asp Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Glu Glu 
    290                 295                 300                 


Lys Asn Leu Leu Lys Gly Ile Ser Phe His Ile His Ile Gly Arg Trp 
305                 310                 315                 320 


Ile Lys Ser Glu His Thr Lys Lys Ile Met Gly Ala Glu Arg Asp Arg 
                325                 330                 335     


Arg Leu Leu Lys Asp Ile Arg Thr Phe Gly Glu Leu Lys Glu Phe Ser 
            340                 345                 350         


Pro Glu His Ala Pro Asp Tyr Trp Leu Arg Asp Gly Ile Thr Pro Asp 
        355                 360                 365             


Asp Val Asp Gln Phe Ser Pro Gln Tyr Arg Ile Val Gly Asn Arg Ile 
    370                 375                 380                 


Gly Ile Lys Leu Asn Tyr Asn Gly His Asn Arg Trp Ser Val Pro Asp 
385                 390                 395                 400 


Lys Glu Ile Asn Val Lys Pro Asp Ala Ile Ile Ser Thr Tyr Glu Phe 
                405                 410                 415     


Leu Asn Leu Phe Leu Tyr Glu His Leu Tyr Gln Lys Lys Leu Thr Gly 
            420                 425                 430         


Leu Ser Pro Ala Glu Phe Ile Gln Asp Tyr Leu Asp Arg Phe Asn Asn 
        435                 440                 445             


Phe Leu Ser Glu Phe Lys Ala Gly His Ile Arg Pro Val Gly Asp Phe 
    450                 455                 460                 


Ser Leu Glu Lys Arg Arg Gly Gln Gly Asp Glu Pro Asp Leu Thr Ala 
465                 470                 475                 480 


Arg Arg Lys Ser Leu Gln Lys Glu Leu Asp Arg Phe Val Leu Lys Gly 
                485                 490                 495     


Lys Asp Leu Pro Asp Lys Ile Arg Glu Tyr Leu Leu Gly Tyr Lys Gln 
            500                 505                 510         


Lys Ser Glu Lys Lys Gln Ala Lys Trp Ile Leu Gly Gly Met Ile Lys 
        515                 520                 525             


Glu Thr Val Tyr Trp Arg Asn Lys Ala Glu Gln Ser Pro Glu Lys Met 
    530                 535                 540                 


Arg Ser Gly Asp Met Ala Gln Gln Leu Ala Arg Asp Ile Ile Phe Leu 
545                 550                 555                 560 


Thr Pro Pro His Thr Val Lys Glu His Lys Gln Lys Leu Asn Ser Leu 
                565                 570                 575     


Glu Tyr Asp Val Leu Gln Tyr Ala Leu Ala Tyr Phe Ser Ser Asn Arg 
            580                 585                 590         


Glu Lys Leu Tyr Ser Phe Phe Lys Glu His Gln Leu Thr Val Lys Gly 
        595                 600                 605             


Asp Arg Ala His Pro Phe Leu Tyr Lys Ile Arg Leu Asp Glu Cys Gln 
    610                 615                 620                 


Gly Ile Leu Asp Phe Phe Ile Val Tyr Met Gln Gln Lys Glu Lys Trp 
625                 630                 635                 640 


Leu Gly Trp Leu Asp Arg Asn Leu Lys Ser Pro Arg Leu Asn Glu Glu 
                645                 650                 655     


Glu Phe Phe Asn Thr Tyr Ser Tyr Phe Ile Lys Thr Asp Thr Lys Arg 
            660                 665                 670         


Ala Ile Glu Met Asp Tyr Glu Ser Cys Pro Asn Tyr Leu Pro Arg Gly 
        675                 680                 685             


Ile Phe Asn Glu Pro Ile Ala Lys Ala Leu Gln Lys Ala Gly Val Lys 
    690                 695                 700                 


Ile Lys Asp Glu Asp Asn Ala Ser Tyr Ala Leu Ser Val Tyr Ser Asn 
705                 710                 715                 720 


Gly Lys Thr Gln Pro Phe Tyr Asn Lys Glu Arg Tyr Tyr Asn Lys Gly 
                725                 730                 735     


Ile Phe Arg Met Glu Glu Leu Pro Glu Lys Leu Gln Pro Lys Glu Leu 
            740                 745                 750         


Leu Gly Lys Ile Gln Trp Thr Ile Lys Ser Ser Gly Lys Asp Thr Glu 
        755                 760                 765             


Glu Phe Arg Ser Leu Gln Asn Leu Lys Asn Arg Ile Leu Asn Thr Glu 
    770                 775                 780                 


Lys Glu Ile Arg Tyr Val Gln Ser Thr Asp Arg Ala Leu Trp Ile Met 
785                 790                 795                 800 


Val Ala Asp Leu Phe Pro Glu Thr Phe Glu Leu Arg Pro Asp Asp Leu 
                805                 810                 815     


Glu Cys Ile Gly His Asp Leu Ser Asp Asp Leu Leu Ser Arg Pro Tyr 
            820                 825                 830         


Gln Met Lys Glu Lys Val Tyr Asn Tyr Thr Ile Thr Asp Tyr Leu Pro 
        835                 840                 845             


Ile Lys Arg Tyr Gly Glu Phe Arg Arg Phe Leu Lys Asp Arg Arg Leu 
    850                 855                 860                 


Glu Asn Leu Leu Thr Tyr Phe Glu Glu Gly Val Pro Leu His Arg Glu 
865                 870                 875                 880 


Ala Leu Val Ala Glu Leu Glu Ala Tyr Asp Leu Gln Arg Lys Asn Leu 
                885                 890                 895     


Leu Glu Ile Ile Tyr Arg Phe Glu Lys Leu Val Phe Asp Arg His Arg 
            900                 905                 910         


His Glu Leu Thr Phe Ser Gly Glu Gly Glu Asn Gln Tyr Val Asn His 
        915                 920                 925             


Trp Asp Tyr Leu Asp Phe Val Ala Arg Lys Tyr Gly Leu Ser Ala Glu 
    930                 935                 940                 


Val Lys Glu Leu Asn Ser Glu Arg Phe Thr Glu Leu Arg Asn Lys Met 
945                 950                 955                 960 


Leu His Asn Gln Ile Pro Tyr Gln Leu Trp Ile Lys Glu Ala Ile Ala 
                965                 970                 975     


Ala Arg Glu Glu Asn Thr Val Cys Gly Arg Ile Met Gly Met Ile Gly 
            980                 985                 990         


Glu Ile Tyr Glu Arg Met Thr Thr  Glu Ile Glu Lys Gln  Met Gln Val 
        995                 1000                 1005             


<210>  1794
<211>  1150
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1794

Val Lys Met Glu Asp Asp Lys Lys Thr Thr Glu Ser Thr Asn Met Leu 
1               5                   10                  15      


Asp Asn Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Val Tyr Ile Thr Val Asn His Ile Asn Lys Val Leu Glu Leu Lys Asn 
        35                  40                  45              


Lys Lys Asp Gln Asp Ile Ile Ile Asp Asn Asp Gln Asp Ile Leu Ala 
    50                  55                  60                  


Ile Lys Thr His Trp Glu Lys Val Asn Gly Asp Leu Asn Lys Thr Glu 
65                  70                  75                  80  


Arg Leu Arg Glu Leu Met Thr Lys His Phe Pro Phe Leu Glu Thr Ala 
                85                  90                  95      


Ile Tyr Thr Lys Asn Lys Glu Asp Lys Lys Glu Val Lys Gln Glu Lys 
            100                 105                 110         


Gln Ala Lys Ala Gln Ser Phe Asp Ser Leu Lys His Cys Leu Phe Leu 
        115                 120                 125             


Phe Leu Glu Lys Leu Gln Glu Ala Arg Asn Tyr Tyr Ser His Tyr Lys 
    130                 135                 140                 


Tyr Ser Glu Ser Thr Lys Glu Pro Met Leu Glu Lys Glu Leu Leu Lys 
145                 150                 155                 160 


Lys Met Tyr Asn Ile Phe Asp Asp Asn Ile Gln Leu Val Ile Lys Asp 
                165                 170                 175     


Tyr Gln His Asn Lys Asp Ile Asn Pro Asp Glu Asp Phe Lys His Leu 
            180                 185                 190         


Asp Arg Thr Glu Glu Asp Phe Asn Tyr Tyr Phe Thr Arg Asn Lys Lys 
        195                 200                 205             


Gly Asn Ile Thr Ala Ser Gly Leu Leu Phe Phe Val Ser Leu Phe Leu 
    210                 215                 220                 


Glu Lys Lys Asp Ala Ile Trp Met Gln Gln Lys Leu Arg Gly Phe Lys 
225                 230                 235                 240 


Asp Asn Arg Glu Ser Lys Lys Lys Met Thr His Glu Val Phe Cys Arg 
                245                 250                 255     


Arg Arg Met Leu Leu Pro Lys Leu Arg Leu Glu Ser Thr Gln Thr Gln 
            260                 265                 270         


Asp Trp Ile Leu Leu Asp Met Leu Asn Glu Leu Ile Arg Cys Pro Lys 
        275                 280                 285             


Ser Leu Tyr Glu Arg Leu Gln Gly Asp Asp Arg Lys Lys Phe Asn Val 
    290                 295                 300                 


Pro Phe Asp Pro Ala Asp Glu Asn Tyr Asp Ala Glu Gln Glu Pro Phe 
305                 310                 315                 320 


Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Ala Leu 
                325                 330                 335     


Arg Tyr Phe Asp Tyr Asn Glu Ile Phe Ala Asn Leu Arg Phe Gln Ile 
            340                 345                 350         


Asp Leu Gly Thr Tyr His Phe Ser Ile Tyr Lys Lys Leu Ile Gly Gly 
        355                 360                 365             


Gln Lys Glu Asp Arg His Leu Thr His Lys Leu Tyr Gly Phe Glu Arg 
    370                 375                 380                 


Ile Gln Glu Phe Ala Lys Gln Asn Arg Thr Asp Glu Trp Lys Ala Ile 
385                 390                 395                 400 


Val Lys Asp Leu Asp Thr Tyr Glu Thr Ser Asn Glu Arg Tyr Ile Ser 
                405                 410                 415     


Glu Thr Thr Pro His Tyr His Leu Glu Asn Gln Lys Ile Gly Ile Arg 
            420                 425                 430         


Phe Arg Asn Asp Asn Asp Glu Ile Trp Pro Ser Leu Lys Thr Asn Gly 
        435                 440                 445             


Glu Asn Asn Glu Lys Arg Lys Tyr Lys Leu Asp Lys Gln Tyr Gln Ala 
    450                 455                 460                 


Glu Ala Phe Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr 
465                 470                 475                 480 


Leu Leu Leu Lys Met Glu Asn Thr Asp Asn Gly Lys Glu Asn Asn Glu 
                485                 490                 495     


Val Gly Thr Lys Lys Lys Arg Asn Lys Asn Asn Glu Gln Glu Lys His 
            500                 505                 510         


Lys Ile Glu Glu Ile Ile Glu Asn Lys Ile Lys Asp Ile Tyr Ala Leu 
        515                 520                 525             


Tyr Asp Ala Phe Ala Asn Gly Glu Ile Asn Ser Glu Glu Glu Leu Lys 
    530                 535                 540                 


Glu Tyr Leu Lys Gly Lys Asp Ile Glu Ile Val His Leu Pro Lys Gln 
545                 550                 555                 560 


Met Val Ala Ile Leu Tyr Asp Glu His Lys Asp Met Val Glu Glu Ala 
                565                 570                 575     


Lys Arg Lys Gln Lys Glu Met Val Lys Asp Thr Lys Lys Leu Leu Ala 
            580                 585                 590         


Thr Leu Glu Lys Gln Thr Gln Gly Glu Ile Glu Asp Gly Gly Arg Asn 
        595                 600                 605             


Ile Arg Leu Leu Lys Ser Gly Glu Ile Ala Arg Trp Leu Val Asn Asp 
    610                 615                 620                 


Met Met Arg Phe Gln Pro Val Gln Lys Asp Asn Glu Gly Asn Pro Leu 
625                 630                 635                 640 


Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln Met Leu Gln Arg Ser 
                645                 650                 655     


Leu Ala Leu Tyr Asn Lys Glu Glu Lys Pro Thr Arg Tyr Phe Arg Gln 
            660                 665                 670         


Val Asn Leu Ile Asn Ser Ser Asn Pro His Pro Phe Leu Lys Trp Thr 
        675                 680                 685             


Lys Trp Glu Glu Cys Asn Asn Ile Leu Ser Phe Tyr Arg Ser Tyr Leu 
    690                 695                 700                 


Thr Lys Lys Ile Glu Phe Leu Asn Lys Leu Lys Pro Glu Asp Trp Glu 
705                 710                 715                 720 


Lys Asn Gln Tyr Phe Leu Lys Leu Lys Glu Pro Lys Ile Asn Arg Glu 
                725                 730                 735     


Thr Leu Val Gln Gly Trp Lys Asn Gly Phe Asn Leu Pro Arg Gly Ile 
            740                 745                 750         


Phe Thr Glu Pro Ile Arg Glu Trp Phe Lys Arg His Gln Asn Asp Ser 
        755                 760                 765             


Lys Glu Tyr Glu Asn Val Glu Ala Leu Asp Arg Val Gly Leu Val Thr 
    770                 775                 780                 


Lys Val Ile Pro Leu Phe Phe Lys Glu Glu Asp Phe Lys Asp Lys Glu 
785                 790                 795                 800 


Glu Tyr Leu Lys Lys Asp Ala Gln Lys Glu Ile Asn Asn Cys Val Gln 
                805                 810                 815     


Pro Phe Tyr Ser Leu Pro Tyr Asn Val Gly Asn Ile His Lys Pro Asp 
            820                 825                 830         


Glu Lys Asp Phe Leu Pro Ser Glu Glu Arg Lys Lys Leu Trp Gly Asp 
        835                 840                 845             


Lys Lys Tyr Lys Phe Lys Gly Tyr Lys Ala Lys Val Lys Ser Lys Lys 
    850                 855                 860                 


Leu Thr Asp Lys Glu Lys Glu Glu Tyr Arg Ser Tyr Leu Glu Phe Gln 
865                 870                 875                 880 


Ser Trp Asn Lys Phe Glu Arg Glu Leu Arg Leu Val Arg Asn Gln Asp 
                885                 890                 895     


Ile Val Thr Trp Leu Leu Cys Thr Glu Leu Ile Asp Lys Leu Lys Val 
            900                 905                 910         


Glu Gly Leu Asn Val Glu Glu Leu Gln Lys Leu Arg Leu Lys Asp Ile 
        915                 920                 925             


Asp Thr Asp Thr Ala Lys Gln Glu Lys Asn Asn Ile Leu Asn Arg Val 
    930                 935                 940                 


Met Pro Met Gln Leu Pro Val Thr Val Tyr Glu Ile Asp Asp Ser His 
945                 950                 955                 960 


Asn Ile Val Lys Asp Arg Pro Leu His Thr Val Tyr Ile Glu Glu Thr 
                965                 970                 975     


Lys Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys Asp 
            980                 985                 990         


Arg Arg Leu Asn Gly Leu Phe Ser  Phe Val Asp Thr Ser  Ser Glu Thr 
        995                 1000                 1005             


Glu Leu  Lys Ser Lys Pro Ile  Ser Lys Ser Val Val  Glu Tyr Glu 
    1010                 1015                 1020             


Leu Gly  Glu Tyr Gln Asn Ala  Arg Ile Glu Ile Ile  Glu Asp Met 
    1025                 1030                 1035             


Leu Ala  Leu Glu Glu Thr Leu  Ile Glu Lys Asp Lys  Asn Leu Pro 
    1040                 1045                 1050             


Thr Asn  Asn Phe Ser Asp Met  Leu Asn Gly Trp Leu  Glu Gly Lys 
    1055                 1060                 1065             


Asp Glu  Ser Asp Lys Ala Arg  Phe Gln Asn Asp Val  Lys Leu Leu 
    1070                 1075                 1080             


Val Ala  Val Arg Asn Ala Phe  Ser His Asn Gln Tyr  Pro Met Arg 
    1085                 1090                 1095             


Asn Arg  Ile Ala Phe Ala Asn  Ile Asn Pro Phe Ser  Leu Ser Ser 
    1100                 1105                 1110             


Ala Asp  Thr Ser Glu Glu Lys  Gly Leu Asp Ile Ala  Asn Gln Leu 
    1115                 1120                 1125             


Lys Asp  Lys Thr His Lys Ile  Ile Lys Arg Ile Ile  Lys Ile Glu 
    1130                 1135                 1140             


Lys Pro  Ile Glu Thr Lys Glu  
    1145                 1150 


<210>  1795
<211>  1138
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1795

Met Glu Thr Gln Glu Asn Glu Leu Phe Glu Asn Arg Arg Arg Thr Leu 
1               5                   10                  15      


Ala Asp Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Leu Ala Arg Leu 
            20                  25                  30          


Asn Ile Phe Ser Ile Asn Asn Tyr Leu Ala Lys Glu Phe Gln Gln Thr 
        35                  40                  45              


Glu Leu Arg Asp Asp Glu Leu Ile Gln Asn Gly Phe Ile Cys Ile Pro 
    50                  55                  60                  


Ser Gln Lys Asn Arg Asn Asp Asn Lys Leu Phe Glu Arg Leu Ile Arg 
65                  70                  75                  80  


Leu Met Pro Val Ile Lys Gln Phe Asp Ala Ala Arg Leu Pro Asn Glu 
                85                  90                  95      


Glu Gln Lys Ser Gly Gln Ala Glu Gly Lys Asp Ile Lys Thr Met Ala 
            100                 105                 110         


Lys Thr Leu Lys Ala Leu Phe Lys Asp Met Gln Glu Phe Arg Asn Asp 
        115                 120                 125             


Tyr Thr His Phe Tyr Ala Thr Asp Lys Gln Glu Cys Arg Lys Leu Thr 
    130                 135                 140                 


Val Ser Ser Glu Thr Ala Thr Phe Leu Lys Ala Ser Phe Ala Arg Ala 
145                 150                 155                 160 


Ile Glu Tyr Ser Lys Val Arg Phe Lys Asp Val Leu Ala Glu Asp Asp 
                165                 170                 175     


Tyr Ser Leu Val Ala Gly Lys Glu Leu Val Glu Asp Glu Asn Thr Ile 
            180                 185                 190         


Thr Thr Glu Gly Leu Val Phe Phe Thr Ala Leu Phe Leu Asp Arg Glu 
        195                 200                 205             


Asn Ala Phe Gln Phe Ile Gly Lys Val Gln Gly Leu Lys Gly Thr Gln 
    210                 215                 220                 


Phe Lys Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ala Tyr Cys Val 
225                 230                 235                 240 


Arg Leu Pro His Asp Lys Leu Ile Ser Asp Asn Pro Ile Gln Ala Leu 
                245                 250                 255     


Leu Phe Asp Ile Leu Asn Glu Leu Asn Lys Cys Pro Lys Lys Leu Tyr 
            260                 265                 270         


Asn Val Leu Ser Glu Glu Val Lys Lys Glu Phe Arg Pro Glu Leu Ser 
        275                 280                 285             


Glu Ser Gly Ile Glu Asn Met Leu Ala Asn Ser Phe Asn Asp Glu Glu 
    290                 295                 300                 


Arg Glu Lys Leu Leu Asp Glu Ile Glu Tyr Lys Glu Tyr Ile Glu Gln 
305                 310                 315                 320 


Leu Thr Ile Arg Val Arg His Ser Asn Arg Phe His Tyr Phe Ala Met 
                325                 330                 335     


Arg Phe Ile Asp Glu Gln Glu Leu Trp Pro Gly Ile Arg Phe Gln Ile 
            340                 345                 350         


Asp Leu Gly Lys Tyr Thr Leu Thr Gln Tyr Asp Lys Gln Val Leu Gly 
        355                 360                 365             


Glu Ser Ile Pro Arg Ser Val Val Glu Asn Thr Arg Ala Phe Gly Arg 
    370                 375                 380                 


Leu Ser Asn Phe Leu Thr Ala Asp Pro Asp Ser Leu Glu Gln Arg Ile 
385                 390                 395                 400 


Asp Val Asp His Arg Ala Asn Gly Phe Glu Gln Phe Ala Pro His Tyr 
                405                 410                 415     


Asn Ala Asp Ile Asn Lys Ile Gly Ile Ala Phe Thr Glu Lys Glu Gln 
            420                 425                 430         


Leu Pro Tyr Val Val Pro Thr Lys Asn Ala Glu Thr Asn Arg Val Lys 
        435                 440                 445             


Tyr Ser Phe Lys Gln Pro Gln Pro Asp Ala Phe Ile Ser Leu His Glu 
    450                 455                 460                 


Leu Ala Lys Ala Ile Leu Leu Glu Gln Leu Gln Pro Gly Glu Ser Glu 
465                 470                 475                 480 


Lys Leu Ile Arg Ala Phe Cys Ser Thr Ala Glu Asn Lys Leu Phe Asn 
                485                 490                 495     


Leu Glu Phe Ile Glu Ser Ile Lys Trp Lys Leu Pro Asp Trp Lys Pro 
            500                 505                 510         


Phe Gln Lys Gln Cys Asp Thr Lys Lys Ser Arg Ala Tyr Ile Thr Lys 
        515                 520                 525             


Lys Lys Met Phe Ala Tyr Ala Pro Arg Asp Arg Lys Lys Leu Leu Asp 
    530                 535                 540                 


Glu Leu Leu Ala Pro Tyr Gly Leu Asn Trp Lys Gln Val Pro Glu Arg 
545                 550                 555                 560 


Ile Leu Asn Tyr Trp Leu Asn Ile Glu Glu Val His Asp Ala Arg Ser 
                565                 570                 575     


Ile Lys Glu Arg Ile Leu Leu Met Lys Arg Asp Gly Leu Lys Arg Leu 
            580                 585                 590         


Lys Gln Leu Glu Lys His Arg Lys Asp Pro Ser Ile Arg Ile Pro Lys 
        595                 600                 605             


Val Gly Glu Met Ala Thr Phe Leu Ala Arg Asp Ile Val Asp Met Met 
    610                 615                 620                 


Ile Asp Lys Thr Lys Lys Gln Lys Ile Thr Ser Ile Tyr Tyr Asp Lys 
625                 630                 635                 640 


Met Gln Glu Cys Leu Ala Phe Tyr Ala Asp Ala Glu Lys Lys Arg Gln 
                645                 650                 655     


Phe Ile Gly Leu Val Arg Glu Leu Asn Leu Asn Ala Pro Asp Gly His 
            660                 665                 670         


Pro Phe Leu Lys Asn Leu Asn Leu Glu Ser Ile Arg Lys Thr Ser Glu 
        675                 680                 685             


Phe Tyr Lys Leu Tyr Leu Met Glu Lys Val Glu Lys Met Ile Glu Asn 
    690                 695                 700                 


Gly Tyr Lys Ser Asn Gly Asp Lys Arg Phe Lys Asn Ile Ala Trp Ile 
705                 710                 715                 720 


Ile Arg Val Phe Glu Glu Lys Gln Lys Asn Glu Lys Asn Gly Lys Asp 
                725                 730                 735     


Asp Thr Ile Tyr Arg Ile Pro Asn Asn Arg Asn Asp Ile Pro Tyr Thr 
            740                 745                 750         


Ile Arg Gln Trp Glu Lys Glu Thr Ser Thr Leu Glu Glu Trp Leu His 
        755                 760                 765             


Thr Ile Asn His Gly Lys Gln Glu Gly Asp Arg Lys Arg Pro Ile Asp 
    770                 775                 780                 


Leu Pro Thr Asp Leu Phe Asp Ala Arg Leu Cys Glu Leu Met Lys Gly 
785                 790                 795                 800 


Gln Met Gln Glu Asn Gly Gln Thr Phe Ala Asp Thr Ala Lys Tyr Asn 
                805                 810                 815     


Glu Leu Leu Lys Gln Trp Trp Ser Leu Arg Glu Asp Glu Thr Gln Pro 
            820                 825                 830         


Phe Tyr Asn Gly Ala Arg His Tyr Val Ile Lys Glu Glu Ala Val Cys 
        835                 840                 845             


Phe Met Pro Gly Ala Gln Pro Arg Leu Thr Ser Cys Tyr Ala Asp Ala 
    850                 855                 860                 


Val Glu Glu Ala Tyr Asn Arg Leu Ser Ala Glu Arg Asn Ile Ala Arg 
865                 870                 875                 880 


Arg His Asn Lys Gln Leu Pro Leu Ile Gln Lys Gln Lys Val Glu Lys 
                885                 890                 895     


Val Phe Lys His Thr Leu Tyr Asp Thr Glu Arg Glu Ile Arg Leu Leu 
            900                 905                 910         


Gly Glu Gln Asp Arg Ile Leu Leu Leu Met Ala Glu Gln Leu Thr Pro 
        915                 920                 925             


Gly Arg Glu Thr Leu Lys Leu Lys Thr Val Ser Glu Glu Leu Thr Arg 
    930                 935                 940                 


Pro Arg Glu Ile Lys Lys Glu Phe Pro Tyr Ile Ser Asn Tyr Asn Ala 
945                 950                 955                 960 


Gln Gly Glu Lys Leu Pro Lys Asp Glu Pro Lys Pro Lys Ile Lys Val 
                965                 970                 975     


Thr Val Thr Gly Ile Met Gln Leu Lys Asn Ser Asn Asp Leu Asn Arg 
            980                 985                 990         


Phe Ala His Asp Arg Arg Met Pro  Glu Leu Val Ala Tyr  Leu Pro Asn 
        995                 1000                 1005             


Ala Thr  Ile Asp Ala Asp Thr  Leu Arg Tyr Glu Leu  Met Asp Tyr 
    1010                 1015                 1020             


Asn Lys  Ala Arg Leu Thr Val  Phe Asp Ala Val Phe  Arg Leu Glu 
    1025                 1030                 1035             


Lys Ala  Ile Ile Asp Gln Asp  Arg Glu Gly Val Ile  Thr Leu Phe 
    1040                 1045                 1050             


Thr Asp  Glu Gln Gly Glu Ala  Lys Gln Gly Arg Met  Gln His Lys 
    1055                 1060                 1065             


Pro Tyr  Leu Gln Trp Leu Leu  Asn Lys Gly Ile Ile  Thr Gln Pro 
    1070                 1075                 1080             


Glu Ser  Ser Tyr Leu Asn Met  Leu Arg Asn Ser Phe  Ser His Asn 
    1085                 1090                 1095             


Gln Val  Pro His Ile Ala Val  Ala Leu Asn Gly Thr  Glu Val Val 
    1100                 1105                 1110             


Pro Val  Lys Asn Ile Ala Ser  Thr Ile Ala Gly Ala  Tyr Lys Gln 
    1115                 1120                 1125             


Lys Ile  Glu Thr Ile Ile Gly  Lys Ile Gly 
    1130                 1135             


<210>  1796
<211>  1227
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1796

Met Asn Ala Asn Thr Pro Thr Leu Ala Pro Glu Leu Lys Ala Pro Arg 
1               5                   10                  15      


Ile Tyr Asn Gln Gln Asp Thr Pro Trp Tyr Phe Gly Ala His Leu Asn 
            20                  25                  30          


Gln Ala Arg His Asn Leu Phe Leu Ala Leu Asn Glu Leu Thr Ile Lys 
        35                  40                  45              


Ile Gly Gly Asn Pro Ile Glu Asn Asp Asp Gln Leu Gln Ser Ala Lys 
    50                  55                  60                  


Ala Leu Thr Ile Leu Asn Ala Ala Ser Pro Asn Pro Asn Glu Leu Ala 
65                  70                  75                  80  


Lys Ala Met Glu Tyr Tyr Asp Lys Asn Phe Pro Phe Leu Phe Tyr Met 
                85                  90                  95      


Gln Tyr Arg Tyr Glu Thr Asp Gln Glu Arg Asp Glu Arg Ile Phe Ser 
            100                 105                 110         


Arg Gln Lys Asn Arg Arg Ser Ala Pro Val Gln His Ala Tyr Gly Ser 
        115                 120                 125             


Ala Ala Arg Tyr Phe Glu Ile Leu Asn Thr Leu Ile Val Tyr Leu Asn 
    130                 135                 140                 


Lys Ala Arg Asn His Cys Asn His Tyr Thr Tyr Ser Pro Leu Thr Ile 
145                 150                 155                 160 


Lys Lys Asp Leu Val Tyr Leu Leu Asn Asp Val Phe Asp Val Asn Val 
                165                 170                 175     


Arg Leu Ile Lys Ser Arg Phe Asn Leu Glu Glu Ala Gln Leu Asp His 
            180                 185                 190         


Leu Lys Arg Tyr Asn Gly Ile Asp Arg Lys Thr Lys Lys Pro Lys Ser 
        195                 200                 205             


Asn Tyr Arg Phe Trp Tyr Ser Phe Thr Ala Thr Gly Asn Thr Glu Asn 
    210                 215                 220                 


Ile Ser Glu Ala Gly Leu Ala Phe Phe Thr Cys Leu Phe Leu Pro Lys 
225                 230                 235                 240 


Gly Glu Ala Tyr Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Ala 
                245                 250                 255     


Glu Thr Pro Glu Tyr Lys Ala Thr Leu Glu Val Phe Thr Ser Asn Met 
            260                 265                 270         


Leu Arg Val Pro Arg Glu Arg Leu Glu Ser Asp Asn Ser Pro Gln Ala 
        275                 280                 285             


Val Phe Leu Asp Met Cys Asn Glu Leu Ala Arg Cys Pro Ala Glu Leu 
    290                 295                 300                 


Phe Glu Leu Leu Glu Glu Glu Lys Gln Glu Leu Phe Ile Thr Asn Arg 
305                 310                 315                 320 


Leu Glu Asp Glu Asp Asn Thr Asp Ser Ser Gly Asp Gly Pro Glu Thr 
                325                 330                 335     


Lys Met Ile Arg Lys Ser Asp Arg Phe Leu Tyr Phe Ala Gln Arg Tyr 
            340                 345                 350         


Leu Asp Ile Thr Lys Gly Leu Pro Gln Met Arg Phe Gly Val Asp Leu 
        355                 360                 365             


Gly Met Tyr Phe Tyr Ser Ile Tyr Pro Lys Thr Leu Ala Gly Val Asp 
    370                 375                 380                 


Glu Met Arg Gln Leu Thr Lys His Leu Ile Gly Tyr Gly Arg Leu Glu 
385                 390                 395                 400 


Asp Phe Asp Thr Asp Lys Arg Pro Ala Ala Phe Ala Ala Leu Tyr Gly 
                405                 410                 415     


Gln Lys Glu Asp Pro Phe Ala Pro Tyr Ile Arg Glu Thr Thr Pro His 
            420                 425                 430         


Tyr His Thr Asp Gly Lys Asn Ile Pro Ile Tyr Ile Gly Ser Ser Ser 
        435                 440                 445             


Cys Glu Trp Pro Glu Ile Gly Thr Thr Asp Val Lys Gly Lys Ser Tyr 
    450                 455                 460                 


Pro Arg Lys Leu Asn Lys Asn Asn Thr Leu Leu Pro Tyr Ala Ile Leu 
465                 470                 475                 480 


Ser Ala Lys Glu Met Pro Ala Leu Met Leu Tyr His Leu Leu Arg Lys 
                485                 490                 495     


Glu Lys Asn Lys Gly Asp Asp Val Gln Lys Val Ile Val Thr His Ile 
            500                 505                 510         


Asn Asn Val Arg Arg Phe Phe Lys Ala Val Leu Asn Gly Ser Glu Arg 
        515                 520                 525             


Pro Val Asp Gln Ser Pro Leu Pro Lys Pro Asp Gly Asp Ala Leu Lys 
    530                 535                 540                 


Gln Arg Ser Asp Lys Glu Tyr Cys Arg Arg Tyr Glu Leu Leu Leu Gln 
545                 550                 555                 560 


Gln Leu Asp Arg Tyr Ala Leu His Pro Ser Tyr Ile Pro Glu Lys Leu 
                565                 570                 575     


Ala Asn Tyr Leu Leu Gly Ile Ala Pro Ser Asp Trp Lys Glu Lys Ala 
            580                 585                 590         


Glu Arg Arg Leu Asn Glu Met Lys Ala Thr Ala Ala Asp Leu Val Glu 
        595                 600                 605             


Arg Met Glu Leu Arg Glu Lys Asp Asp Ile Lys Pro Gly Lys Pro Gly 
    610                 615                 620                 


Phe Arg Lys Val Lys Val Gly Lys Leu Ala Gln Leu Ile Val Glu Asp 
625                 630                 635                 640 


Met Met Leu Met Gln Pro Val Leu Lys Asp Glu Asn Asp Gln Pro Val 
                645                 650                 655     


Pro Asp Ser Lys Ala Asn Gly Leu Ala Tyr Arg Leu Leu Gln Ser His 
            660                 665                 670         


Leu Ala Phe Tyr Gly Val His Arg Asp Asn Ile Thr Glu Leu Phe Ser 
        675                 680                 685             


Ser Cys Lys Leu Thr Gly Gly Thr Asn Pro His Pro Phe Leu His Arg 
    690                 695                 700                 


Ile Asn Val Asn Glu Leu Ser Gly Ile Ile Glu Phe Tyr Lys Ala Tyr 
705                 710                 715                 720 


Phe Asn Glu Lys Ile Asp Tyr Leu Asn Thr Cys Leu Lys Asn Lys Arg 
                725                 730                 735     


Tyr Asp Glu Tyr His Phe Leu Lys Ile Asn Ala Gln Pro Asp Asp Ile 
            740                 745                 750         


Ala Asp Leu Leu Lys Thr Tyr Leu Gln Thr Glu Gly Pro Ser His Ser 
        755                 760                 765             


Pro Phe Asn Leu Pro Arg Gly Phe Phe His Arg Ala Thr Val Asn Trp 
    770                 775                 780                 


Leu Met Leu His Gly Thr Glu Ser Asn Lys Lys Phe Leu Ala Asp His 
785                 790                 795                 800 


Pro Asp Thr Asn Thr Val His Leu Thr Lys His Leu Phe Glu Gln Gln 
                805                 810                 815     


Asp Thr Ala Gln Ala Phe Tyr His Trp Lys Arg His Tyr His Leu Phe 
            820                 825                 830         


Ser Gly Asp Val Pro Leu Tyr Leu Asn Leu Glu Glu Arg Lys Gln Glu 
        835                 840                 845             


Thr Glu Arg Thr Met Lys Ile Val Asn Arg Leu Arg Glu Glu Leu Asp 
    850                 855                 860                 


Asp Met Glu Asp Leu Ala Ala Glu Ala Gln Asp Thr Phe Tyr His Glu 
865                 870                 875                 880 


Ile Lys Arg Leu Arg Ser Leu Asp Asp Ile Ile Arg His Thr Glu Arg 
                885                 890                 895     


Lys Tyr Gly Ala Ser Phe Pro Ala Val Tyr Glu Ile Glu Trp Arg Val 
            900                 905                 910         


Ser Asp Tyr Tyr Met His Lys Asp Ala Thr Arg Leu Val Thr Ala Ala 
        915                 920                 925             


Ile Glu Gly Gln Ile Lys Asp Asn Lys His Tyr Leu Asn Ser Tyr Lys 
    930                 935                 940                 


Phe Phe Ile Glu Asn Glu Lys Tyr Leu Arg Leu Ile Glu Ala Gln Asp 
945                 950                 955                 960 


Met Leu Leu Phe Met Ala Val Lys Asp Leu Leu Lys Glu Lys Ile Gly 
                965                 970                 975     


Asp Ile Ser Leu Thr Glu Thr Gln Asp Lys Glu Ser Gly Thr Phe Leu 
            980                 985                 990         


Leu Ser Asn Ile Ser Pro Gln Asn  Val Glu Asn Asn Lys  Asn Leu Leu 
        995                 1000                 1005             


Asn Gln  Arg Pro Ala Gly Gly  Ile His Ile Asn Leu  Asp Phe Phe 
    1010                 1015                 1020             


Glu Ile  Asn Glu Asn Gly Ser  Phe Arg Lys Ser Glu  Asn Gly Lys 
    1025                 1030                 1035             


Val Lys  Val Gly Thr Ala Thr  Ile Ile Asp Lys His  Leu Lys Ile 
    1040                 1045                 1050             


Lys Asn  Ala Gly Asn Phe Arg  Lys Leu Leu Lys Asp  Arg Arg Ile 
    1055                 1060                 1065             


Asn Asn  Ile Cys Phe Tyr Phe  Lys Pro Asp Ala Gly  His Phe Thr 
    1070                 1075                 1080             


Ile Asn  Arg Met Val Leu Glu  Asn Glu Phe Arg Ala  Tyr Asp Lys 
    1085                 1090                 1095             


Gln Arg  Leu Lys Val Leu Glu  Val Val Ala Ala Phe  Glu Glu Lys 
    1100                 1105                 1110             


Leu Tyr  Leu Asn Ser Asn Lys  Glu Glu Lys Ala Thr  Phe Leu Asn 
    1115                 1120                 1125             


Asn Lys  Gly Val Ala Glu His  Lys Leu Tyr Leu Lys  His Tyr Phe 
    1130                 1135                 1140             


Gly Lys  Phe Thr Asp Asp Asn  Glu Asn Leu Gln Arg  Asn Leu Leu 
    1145                 1150                 1155             


Ala Ile  Arg Asn Ala Phe Ala  His Asn Gln Phe Pro  Leu Ile His 
    1160                 1165                 1170             


Asp Asp  Thr Phe Ala Leu Ser  Ala Asn Glu Trp Arg  Met Ile His 
    1175                 1180                 1185             


Glu Gln  Tyr Gln Pro Ser Ala  Gln Gly Ser His Gln  Gly Tyr Gly 
    1190                 1195                 1200             


Ile Ile  Glu Lys Ile Ser Leu  Tyr Gly Ile Asn Gly  Tyr Gln Ser 
    1205                 1210                 1215             


Leu Ile  Asp Lys Ile Ser Gly  His Val 
    1220                 1225         


<210>  1797
<211>  1158
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1797

Met Lys Asn Gln Asn Thr Leu Pro Ser Asn Pro Thr Asp Ile Leu Lys 
1               5                   10                  15      


Asp Lys Pro Phe Trp Ala Ala Phe Phe Asn Leu Ala Arg His Asn Val 
            20                  25                  30          


Tyr Leu Thr Val Asn His Ile Asn Lys Leu Leu Asp Leu Glu Lys Leu 
        35                  40                  45              


Tyr Asn Lys Asp Lys His Glu Glu Ile Phe Glu Arg Glu Asp Ile Phe 
    50                  55                  60                  


Asn Ile Ser Asp Asp Val Met Asn Asp Ala Asn Ser Asn Gly Lys Lys 
65                  70                  75                  80  


Arg Lys Leu Asp Ile Lys Lys Ile Trp Asp Asp Leu Asp Thr Asp Leu 
                85                  90                  95      


Thr Arg Lys Tyr Gln Leu Arg Glu Leu Ile Leu Lys His Phe Pro Phe 
            100                 105                 110         


Ile Gln Pro Ala Ile Ile Gly Ala Gln Thr Lys Glu Arg Thr Thr Ile 
        115                 120                 125             


Asp Lys Asp Lys Arg Ser Thr Ser Thr Ser Asn Asp Ser Leu Lys Pro 
    130                 135                 140                 


Thr Gly Glu Gly Asp Ile Asn Asp Pro Leu Ser Leu Ser Asn Val Lys 
145                 150                 155                 160 


Ser Ile Phe Phe Arg Leu Leu Gln Met Leu Glu Gln Leu Arg Asn Tyr 
                165                 170                 175     


Tyr Ser His Val Lys His Ser Lys Ser Ala Thr Met Pro Asn Phe Asp 
            180                 185                 190         


Glu Asp Leu Leu Asn Trp Met Arg Tyr Ile Phe Ile Asp Ser Val Asn 
        195                 200                 205             


Lys Val Lys Glu Asp Tyr Ser Ser Asn Ser Val Ile Asp Pro Asn Thr 
    210                 215                 220                 


Cys Phe Ser His Phe Ile Tyr Lys Asp Lys Gln Gly Lys Ile Lys Pro 
225                 230                 235                 240 


Cys Arg Tyr Pro Phe Thr Ser Lys Asp Gly Ser Ile Asn Ala Phe Gly 
                245                 250                 255     


Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys Gln Asp Ser Ile Trp 
            260                 265                 270         


Met Gln Lys Lys Ile Pro Gly Phe Lys Lys Ala Ser Glu Asn Tyr Met 
        275                 280                 285             


Lys Met Thr Asn Glu Val Phe Cys Arg Asn His Ile Leu Leu Pro Lys 
    290                 295                 300                 


Met Arg Leu Glu Ala Val Tyr Asp Lys Asp Trp Met Leu Leu Asp Met 
305                 310                 315                 320 


Leu Asn Glu Val Val Arg Cys Pro Leu Ser Leu Tyr Lys Arg Leu Thr 
                325                 330                 335     


Pro Ala Asp Gln Asn Lys Phe Lys Val Pro Glu Lys Ser Ser Asp Asn 
            340                 345                 350         


Ala Asn Arg Gln Glu Asp Asp Asn Pro Phe Ser Arg Ile Leu Val Arg 
        355                 360                 365             


His Gln Asn Arg Phe Pro Tyr Phe Ala Leu Arg Phe Phe Asp Leu Asn 
    370                 375                 380                 


Glu Val Phe Thr Thr Leu Arg Phe Gln Ile Asn Leu Gly Cys Tyr His 
385                 390                 395                 400 


Phe Ala Ile Cys Lys Lys Gln Ile Gly Asp Lys Lys Glu Ile His His 
                405                 410                 415     


Leu Thr Arg Thr Leu Tyr Gly Phe Ser Arg Leu Gln Asn Phe Thr Gln 
            420                 425                 430         


Asn Thr Arg Pro Glu Glu Trp Asn Thr Leu Val Lys Thr Thr Glu Pro 
        435                 440                 445             


Ser Ser Gly Asn Asp Gly Lys Thr Val Gln Gly Val Pro Leu Pro Tyr 
    450                 455                 460                 


Ile Ser Tyr Thr Ile Pro His Tyr Gln Ile Glu Asn Glu Lys Ile Gly 
465                 470                 475                 480 


Ile Lys Ile Phe Asp Gly Asp Thr Ala Val Asp Thr Asp Ile Trp Pro 
                485                 490                 495     


Ser Val Ser Thr Glu Lys Gln Leu Asn Lys Pro Asp Lys Tyr Thr Leu 
            500                 505                 510         


Thr Pro Gly Phe Lys Ala Asp Val Phe Leu Ser Val His Glu Leu Leu 
        515                 520                 525             


Pro Met Met Phe Tyr Tyr Gln Leu Leu Leu Cys Glu Gly Met Leu Lys 
    530                 535                 540                 


Thr Asp Ala Gly Asn Ala Val Glu Gly Val Leu Thr Asp Ala Arg Asn 
545                 550                 555                 560 


Thr Ile Phe Asn Leu Tyr Asp Ala Phe Val Gln Glu Lys Ile Asn Thr 
                565                 570                 575     


Ile Thr Asp Leu Glu Asn Tyr Leu Gln Asp Lys Pro Ile Leu Ile Gly 
            580                 585                 590         


His Leu Pro Lys Gln Met Ile Asp Leu Leu Lys Gly His Gln Lys Asp 
        595                 600                 605             


Met Leu Lys Ala Ala Glu Gln Lys Lys Ala Met Leu Ile Lys Asp Thr 
    610                 615                 620                 


Glu Arg Arg Leu Glu Arg Leu Asn Lys Gln Pro Glu Gln Lys Pro Asp 
625                 630                 635                 640 


Val Ala Ala Lys Asn Thr Gly Thr Leu Leu Arg Asn Gly Gln Ile Ala 
                645                 650                 655     


Asp Trp Leu Val Lys Asp Met Met Arg Phe Gln Pro Val Lys Arg Asp 
            660                 665                 670         


Lys Glu Gly Asp Pro Ile Asn Cys Ser Lys Ala Asn Ser Thr Glu Tyr 
        675                 680                 685             


Gln Met Leu Gln Arg Ala Phe Ala Phe Tyr Ala Thr Asp Ser Cys Arg 
    690                 695                 700                 


Leu Pro Arg Tyr Phe Glu Gln Leu His Leu Ile Asn Cys Asp Asn Ser 
705                 710                 715                 720 


His Leu Phe Leu Ser Arg Phe Glu Tyr Asp Lys Gln Pro Asn Leu Ile 
                725                 730                 735     


Ala Phe Tyr Ala Ala Tyr Leu Glu Ala Lys Leu Glu Phe Leu Asn Glu 
            740                 745                 750         


Leu Gln Pro Gln Asn Trp Ala Ser Asp Asn Tyr Phe Leu Leu Leu Arg 
        755                 760                 765             


Ala Pro Lys Asn Asp Arg Gln Lys Leu Ala Glu Gly Trp Lys Asn Gly 
    770                 775                 780                 


Phe Asn Leu Pro Arg Gly Leu Phe Thr Glu Lys Ile Lys Thr Trp Phe 
785                 790                 795                 800 


Asn Glu His Lys Thr Ile Val Asp Ile Ser Asn Cys Asp Ile Phe Lys 
                805                 810                 815     


Asn Arg Val Gly Gln Val Ala Arg Leu Ile Pro Val Phe Phe Asp Lys 
            820                 825                 830         


Lys Phe Lys Asp His Ser Gln Pro Phe Tyr Arg Tyr Asp Phe Asn Val 
        835                 840                 845             


Gly Asn Val Ser Lys Pro Thr Glu Ala Asn Tyr Leu Ser Lys Glu Lys 
    850                 855                 860                 


Arg Glu Glu Leu Phe Lys Ser Tyr Gln Asn Lys Phe Lys Asn Asn Ile 
865                 870                 875                 880 


Pro Ala Lys Lys Thr Thr Glu Tyr Pro Glu Tyr Lys Asn Phe Ser Ser 
                885                 890                 895     


Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys Asn Gln Asp Ile 
            900                 905                 910         


Leu Thr Trp Leu Met Cys Lys Asn Leu Phe Asp Glu Gln Lys Asp Lys 
        915                 920                 925             


Lys Val Asn Val Ser Asp Ile Lys Leu Asp Ser Leu Gln Thr Asn Thr 
    930                 935                 940                 


Ser Thr Lys Gly Ser Leu Asn Ala Leu Ala Gln Val Val Pro Met Val 
945                 950                 955                 960 


Leu Ala Ile His Ile Gly Asn Ser Glu Ser Lys Asn Glu Thr Gly Thr 
                965                 970                 975     


Asn Glu Lys Glu Asn Lys Gly Pro Ala Val Tyr Ile Lys Glu Glu Gly 
            980                 985                 990         


Thr Lys Leu Leu Lys Trp Gly Asn  Phe Lys Thr Leu Leu  Ala Asp Arg 
        995                 1000                 1005             


Arg Ile  Lys Gly Leu Phe Ser  Tyr Ile Glu His Asp  Asp Ile Asp 
    1010                 1015                 1020             


Leu Lys  Gln His Pro Leu Thr  Lys Arg Arg Val Asp  Leu Glu Leu 
    1025                 1030                 1035             


Asp Leu  Tyr Gln Thr Cys Arg  Ile Gly Ile Phe Arg  Gln Thr Leu 
    1040                 1045                 1050             


Gly Leu  Glu Ala Gln Leu Leu  Asp Lys Tyr Ser Asp  Leu Asn Thr 
    1055                 1060                 1065             


Asp Asn  Phe Asn Lys Met Leu  Ser Gly Trp Ser Glu  Lys Glu Gly 
    1070                 1075                 1080             


Ile Ser  Arg Glu Ile Lys Glu  Asp Thr Asp Phe Leu  Lys Asp Val 
    1085                 1090                 1095             


Arg Asn  Ala Phe Ser His Asn  Gln Tyr Pro Asp Ser  Lys Lys Ile 
    1100                 1105                 1110             


Ala Phe  Ser Arg Ile Arg Lys  Phe Asn Pro Lys Glu  Leu Ile Leu 
    1115                 1120                 1125             


Glu Glu  Glu Glu Gly Leu Asp  Ile Ala Lys Gln Met  Tyr Lys Glu 
    1130                 1135                 1140             


Val Lys  Lys Val Val Asn Arg  Ile Lys Glu Ile Glu  Leu Phe Asp 
    1145                 1150                 1155             


<210>  1798
<211>  1133
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1798

Val Lys Met Glu Asp Asp Lys Lys Thr Thr Glu Ser Thr Tyr Thr Leu 
1               5                   10                  15      


Asp Asn Lys His Phe Gly Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Val Tyr Ile Thr Val Asn His Ile Asn Lys Ile Leu Glu Glu Gly Glu 
        35                  40                  45              


Ile Asn Arg Asp Gly Tyr Glu Thr Thr Leu Lys Asn Ser Trp Asp Glu 
    50                  55                  60                  


Ile Lys Asp Ile Asn Lys Lys Asp Arg Leu Ser Lys Leu Ile Ile Lys 
65                  70                  75                  80  


His Phe Ser Phe Leu Glu Ala Ala Thr Tyr Arg Gln Asn Pro Thr Asp 
                85                  90                  95      


Thr Thr Lys Gln Lys Glu Glu Lys Gln Ala Glu Ala Gln Ser Leu Glu 
            100                 105                 110         


Ser Leu Lys Lys Ser Phe Phe Val Phe Ile Tyr Lys Leu Arg Asp Leu 
        115                 120                 125             


Arg Asn His Tyr Ser His Tyr Lys His Ser Lys Ser Leu Glu Arg Pro 
    130                 135                 140                 


Lys Phe Glu Glu Asp Leu Leu Lys Lys Met Tyr Asn Ile Phe Asn Ala 
145                 150                 155                 160 


Ser Ile Arg Leu Val Lys Glu Asp Tyr Lys His Asn Lys Asn Ile Asn 
                165                 170                 175     


Pro Lys Lys Asp Phe Lys His Leu Asn Arg Lys Arg Lys Gly Lys Phe 
            180                 185                 190         


Tyr Tyr Ser Phe Ala Asp Asn Glu Gly Asn Ile Thr Glu Ser Gly Leu 
        195                 200                 205             


Leu Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Val 
    210                 215                 220                 


Gln Lys Lys Leu Glu Gly Phe Lys Cys Ser Asn Glu Ser Tyr Gln Lys 
225                 230                 235                 240 


Met Thr Asn Glu Val Phe Cys Arg Ser Arg Met Leu Leu Pro Lys Leu 
                245                 250                 255     


Arg Leu Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu 
            260                 265                 270         


Asn Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Arg Gly 
        275                 280                 285             


Asp Asp Arg Glu Lys Phe Arg Val Pro Leu Asp Pro Ile Asp Glu Asp 
    290                 295                 300                 


Tyr Asp Ala Glu Gln Glu Pro Phe Lys Asn Thr Leu Val Arg His Gln 
305                 310                 315                 320 


Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Tyr Asn Glu Ile 
                325                 330                 335     


Phe Ser Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser 
            340                 345                 350         


Ile Tyr Lys Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg His Leu Thr 
        355                 360                 365             


His Lys Leu Tyr Gly Phe Glu Arg Ile Gln Glu Phe Asp Lys Gln Asn 
    370                 375                 380                 


Arg Thr Asp Glu Trp Lys Ser Ile Val Lys Asp Leu Asp Thr Tyr Glu 
385                 390                 395                 400 


Thr Ser Asn Glu Arg Tyr Ile Ser Glu Thr Thr Pro His Tyr His Leu 
                405                 410                 415     


Glu Asn Gln Lys Ile Gly Ile Arg Phe Arg Asn Gly Asn Asn Asp Ile 
            420                 425                 430         


Trp Pro Ser Leu Glu Thr Asn Gly Glu Asn Asn Glu Lys Ser Lys Tyr 
        435                 440                 445             


Lys Leu Asp Lys Gln Tyr Gln Ala Glu Ala Phe Leu Ser Val His Glu 
    450                 455                 460                 


Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Lys Thr Glu Asn Thr 
465                 470                 475                 480 


Asp Asn Asp Asn Glu Ile Glu Thr Lys Lys Lys Glu Asn Lys Asn Asp 
                485                 490                 495     


Lys Gln Glu Lys His Lys Ile Glu Glu Ile Ile Glu Asn Lys Ile Lys 
            500                 505                 510         


Asp Ile Tyr Ala Leu Tyr Asp Ala Phe Ala Asn Gly Glu Ile Asn Ser 
        515                 520                 525             


Lys Glu Glu Leu Lys Glu Tyr Leu Lys Gly Lys Asp Ile Glu Ile Val 
    530                 535                 540                 


His Leu Pro Lys Gln Met Ile Ala Ile Leu Glu Ser Lys Pro Lys Asp 
545                 550                 555                 560 


Met Val Glu Glu Ala Glu Arg Lys Gln Arg Lys Met Val Lys Asp Thr 
                565                 570                 575     


Lys Lys Leu Leu Ala Ala Leu Glu Lys Gln Thr Gln Glu Glu Ile Glu 
            580                 585                 590         


Asp Gly Gly Arg Asn Ile Arg Leu Leu Lys Ser Gly Glu Ile Ala Arg 
        595                 600                 605             


Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln Lys Asp Asn 
    610                 615                 620                 


Glu Gly Asn Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln 
625                 630                 635                 640 


Met Leu Gln Arg Ser Leu Ala Leu Tyr Asn Lys Glu Glu Lys Pro Thr 
                645                 650                 655     


Arg Tyr Phe Arg Gln Val Asn Leu Ile Asn Ser Ser Asn Pro His Pro 
            660                 665                 670         


Phe Leu Lys Trp Thr Lys Trp Glu Glu Cys Asn Asn Ile Leu Ser Phe 
        675                 680                 685             


Tyr Arg Ser Tyr Leu Thr Lys Lys Ile Glu Phe Leu Asn Lys Leu Lys 
    690                 695                 700                 


Pro Glu Asp Trp Glu Lys Asn Gln Tyr Phe Leu Lys Leu Lys Glu Pro 
705                 710                 715                 720 


Lys Thr Asn Arg Glu Thr Leu Val Gln Gly Trp Lys Asn Gly Phe Asn 
                725                 730                 735     


Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg Glu Trp Phe Lys Arg 
            740                 745                 750         


His Gln Asn Asn Ser Glu Glu Tyr Glu Lys Val Glu Ala Leu Asp Arg 
        755                 760                 765             


Val Gly Leu Val Thr Lys Val Ile Pro Leu Phe Phe Lys Glu Glu Tyr 
    770                 775                 780                 


Phe Lys Glu Asp Ala Gln Lys Glu Ile Asn Asn Cys Val Gln Pro Phe 
785                 790                 795                 800 


Tyr Ser Phe Pro Tyr Asn Val Gly Asn Ile His Lys Pro Lys Glu Glu 
                805                 810                 815     


Asp Phe Leu His Arg Glu Glu Arg Ile Glu Leu Trp Asp Lys Lys Lys 
            820                 825                 830         


Asp Lys Phe Lys Gly Tyr Lys Ala Lys Lys Lys Phe Lys Glu Met Thr 
        835                 840                 845             


Asp Lys Glu Lys Glu Glu His Arg Ser Tyr Leu Glu Phe Gln Ser Trp 
    850                 855                 860                 


Asn Lys Phe Glu Arg Glu Leu Arg Leu Val Arg Asn Gln Asp Ile Val 
865                 870                 875                 880 


Thr Trp Leu Leu Cys Thr Glu Leu Ile Asp Lys Leu Lys Val Glu Gly 
                885                 890                 895     


Leu Asn Val Glu Glu Leu Lys Lys Leu Arg Leu Lys Asp Ile Asp Thr 
            900                 905                 910         


Asp Thr Ala Lys Gln Glu Lys Asn Asn Ile Leu Asn Arg Val Met Pro 
        915                 920                 925             


Met Gln Leu Pro Val Thr Val Tyr Glu Ile Asp Asp Ser His Asn Ile 
    930                 935                 940                 


Val Lys Asp Arg Pro Leu His Thr Val Tyr Ile Glu Glu Thr Lys Thr 
945                 950                 955                 960 


Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys Asp Arg Arg 
                965                 970                 975     


Leu Asn Gly Leu Phe Ser Phe Val Lys Thr Pro Ser Glu Ala Glu Ser 
            980                 985                 990         


Glu Ser Asn Pro Ile Ser Lys Ser  Arg Val Glu Ser Glu  Leu Gly Lys 
        995                 1000                 1005             


Tyr Gln  Asn Ala Arg Leu Asn  Ile Ile Glu Asp Met  Leu Ala Leu 
    1010                 1015                 1020             


Glu Lys  Thr Leu Ile Asp Asn  Tyr Asn Ser Leu Asp  Thr Asp Asn 
    1025                 1030                 1035             


Phe His  Asn Met Leu Thr Gly  Trp Leu Lys Leu Lys  Gly Lys Ala 
    1040                 1045                 1050             


Asn Lys  Ala Arg Phe Gln Asn  Glu Val Asp Leu Leu  Val Ala Val 
    1055                 1060                 1065             


Arg Asn  Ala Phe Ser His Asn  Gln Tyr Pro Met Tyr  Asn Glu Asn 
    1070                 1075                 1080             


Leu Phe  Gly Asn Ile Glu Arg  Phe Ser Leu Ser Ser  Ser Asn Ile 
    1085                 1090                 1095             


Ile Glu  Ser Lys Gly Leu Asp  Ile Ala Val Lys Leu  Lys Glu Glu 
    1100                 1105                 1110             


Val Ser  Lys Ala Val Glu Lys  Ile Gln Asn Glu Glu  Asp Asp Lys 
    1115                 1120                 1125             


Lys Glu  Lys Glu Thr 
    1130             


<210>  1799
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1799

Met Glu Thr Lys Gln Gln Val Gly Lys Gly Ile Ser Tyr Asp His Arg 
1               5                   10                  15      


Arg Pro Asp Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asp Gly Val Ile Gln Glu Phe Ala Met Arg Leu Asn Arg 
        35                  40                  45              


Glu Tyr Asp Pro Glu Asn Lys Asn Gln Ser Leu Phe Ser Tyr Phe Asn 
    50                  55                  60                  


Ile Asn Ala Ser Phe Thr Asp Trp Glu Arg Gly Val Asn Ile Leu Lys 
65                  70                  75                  80  


Glu Tyr Trp Pro Met Met Glu Phe Ile Asp Arg Pro Ala Thr Asp Lys 
                85                  90                  95      


Gln Phe Glu Ala Glu Lys Pro Glu Asn Arg Glu Ala Ala Lys Arg Lys 
            100                 105                 110         


Tyr Phe Leu Ala Thr Leu Gly Ala Leu Leu Thr Ser Ile Lys Asp Leu 
        115                 120                 125             


Arg His Tyr Tyr Thr His Tyr Tyr His Pro Pro Val His Leu Asn Asp 
    130                 135                 140                 


Asp Leu Phe Leu Phe Leu Asp His Ala Leu Leu Tyr Thr Ala Phe Asp 
145                 150                 155                 160 


Val Lys Lys Thr Lys Met Lys Asp Asp Lys Thr Arg Gln Leu Leu Asn 
                165                 170                 175     


Gln Asn Leu Ser Leu Glu Leu Glu Lys Leu Lys Lys Leu Lys Val Glu 
            180                 185                 190         


Glu Leu Lys Lys Lys Lys Glu Lys Gly Ile Lys Val Asn Leu Gln Asp 
        195                 200                 205             


Glu Lys Gly Ile Leu Asn Ala Ile Tyr Asn Asp Ala Phe Ala His Ile 
    210                 215                 220                 


Ile Thr Lys Glu Lys Asp Ser Asp Lys Asp Lys Leu Glu Thr Arg Tyr 
225                 230                 235                 240 


Lys Ser Ile Leu Pro Gln Asp Glu Ala Ala Glu Thr Gly Ile Asn Ile 
                245                 250                 255     


Ser Ile Ser Gly Leu Ile Phe Leu Leu Ser Leu Phe Leu Ser Arg Lys 
            260                 265                 270         


Glu Ile Glu Gln Leu Lys Ser Asn Ile Glu Gly Tyr Lys Gly Lys Val 
        275                 280                 285             


Leu Asn Ile Glu Thr Glu Val Asp Arg Lys His Asn Ser Leu Lys Tyr 
    290                 295                 300                 


Met Ala Thr His Trp Val Phe Ser Ile Leu Ala Phe Lys Gly Leu Lys 
305                 310                 315                 320 


Gln Arg Leu Thr Asn Ser Phe Glu Lys Glu Ser Leu Leu Ile Gln Met 
                325                 330                 335     


Met Asp Glu Leu Asn Lys Val Pro Asp Glu Leu Tyr Gln Thr Leu Ser 
            340                 345                 350         


Glu Thr Ala Lys Lys Glu Phe Leu Glu Asp Ile Asn Glu Tyr Val Ser 
        355                 360                 365             


Glu Gly Asp Asp Asn Glu Lys Ala Thr Tyr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Ser Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gln Phe Pro Thr Leu Lys Phe Gln Ile Phe Val Gly 
                405                 410                 415     


Gln Tyr Leu His Asp Asn Arg Pro Lys Thr Leu Ala Ser Asn Gly Met 
            420                 425                 430         


Thr Ala Gln Arg Met Ile Lys Glu Lys Ile Asn Leu Phe Gly Asn Leu 
        435                 440                 445             


Ser Glu Val Thr Lys His Lys Ser Asp Phe Phe Glu Lys Glu Ser Ala 
    450                 455                 460                 


Ala Gln Gly Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Trp Ala Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Val Tyr Ile Asp Met Ile Gly Lys Glu Gly Lys Ala 
                485                 490                 495     


Lys Glu Ile Gln Val Gln Ile Asn Lys Tyr Arg Lys Gln Leu Asn Pro 
            500                 505                 510         


Ala Pro Gln Arg Asp Lys Arg Ile Ser Lys Lys Glu Ile Ile Glu Gln 
        515                 520                 525             


Leu Tyr Lys Glu Lys Val Val Tyr Gly Asp Pro Thr Leu Met Leu Ser 
    530                 535                 540                 


Ala Asn Glu Leu Met Ala Leu Leu Tyr Glu Leu Ile Val Asn Gly Lys 
545                 550                 555                 560 


Ser Gly Ala Glu Leu Glu Asn Lys Ile Val Glu Gln Ile Ile Ala Arg 
                565                 570                 575     


Tyr Glu Gln Ile Glu Ala Tyr Asp Pro Thr Thr Gln Gln Leu Pro Thr 
            580                 585                 590         


Asn Gln Met Pro His Lys Leu Gln Lys Ser Arg Lys Asp Ser Lys Val 
        595                 600                 605             


Thr Asp Thr Asp Lys Leu Leu Lys Thr Ile Asp Lys Glu Ile Asp Glu 
    610                 615                 620                 


Gly Asn Lys Lys Leu Glu Leu Ile Ala Cys His Arg Lys Glu Trp Glu 
625                 630                 635                 640 


Glu Ala Glu Gln Arg Lys Lys Ser Gly Lys Arg Asn Asn Pro Gly Thr 
                645                 650                 655     


Lys Ser Arg Lys His Leu Phe Tyr Ala Ser Glu Met Gly Glu Glu Ala 
            660                 665                 670         


Thr Trp Ile Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Pro Ala Arg 
        675                 680                 685             


Ala Glu Trp Lys Gly Thr His His Ser Glu Leu Gln Arg Leu Leu Ala 
    690                 695                 700                 


Phe Tyr Ser Thr Gln Arg Leu Glu Ala Trp Gln Leu Val Glu Ser Val 
705                 710                 715                 720 


Trp Thr Ala Asn Thr His Ser Phe Trp Glu Glu Asn Phe Lys Glu Ala 
                725                 730                 735     


Phe Tyr Lys Pro Glu Phe Glu Asn Phe Tyr Gly Ala Tyr Ile Glu Ile 
            740                 745                 750         


Arg Thr Lys Ile Leu Thr Thr Cys Arg Ser Ile Leu Glu Asn Asn Pro 
        755                 760                 765             


Glu Ala Thr Met Asn Asn Asp Thr Glu Lys Glu Trp Asp Lys Val Phe 
    770                 775                 780                 


Thr Leu Phe Asp Lys Arg Leu Tyr Arg Thr Ser Thr Thr Asp Glu Gln 
785                 790                 795                 800 


Lys Lys Gln Leu Leu Thr Lys Pro Phe Ala Phe Pro Arg Gly Leu Phe 
                805                 810                 815     


Asp Asp Lys Pro Thr Phe Leu Pro Gly Ser Lys Pro Asn Glu Asn Pro 
            820                 825                 830         


Glu Arg Phe Ala Ala Trp Tyr Ser Tyr Gly Tyr Thr Tyr Ser Gly Lys 
        835                 840                 845             


Phe Gln Ser Phe Tyr Asp Met Pro Arg Asn Tyr Ser Asp Trp Tyr Lys 
    850                 855                 860                 


Lys Leu Lys Glu Asp Gly Lys Leu Pro Arg Leu Asp Lys Lys Thr Glu 
865                 870                 875                 880 


Gln Glu Lys Ile Leu Arg Phe Arg Met Asp Cys Asp Leu Asn Ile Lys 
                885                 890                 895     


His Ile Arg Phe Gln Asp Ile Tyr Val Lys Leu Met Val Asp Ser Leu 
            900                 905                 910         


Tyr Lys Ala Val Phe Gly Gln Gln Pro Glu Phe Asp Leu Ser His Leu 
        915                 920                 925             


Tyr Asp Thr Arg Ser Glu Arg Tyr Glu Asn Asn Thr Ile Ala Gln Arg 
    930                 935                 940                 


Gln Lys Ser Arg Gln Glu Gly Asp Asn Ser Asp Asn Ala Ile Asn Glu 
945                 950                 955                 960 


Asn Tyr Val Trp Asn Lys Thr Phe Ala Ile Ser Leu Tyr Asn Gly Arg 
                965                 970                 975     


Ile Thr Glu Ser Gln Val Lys Leu Lys Asp Val Gly Lys Phe Arg Arg 
            980                 985                 990         


Phe Ala Thr Asp Pro Arg Val Gln  Thr Leu Ile Ser Tyr  Asp Asp Thr 
        995                 1000                 1005             


Arg Thr  Trp Thr Lys Leu Glu  Ile Glu Asn Glu Leu  Asp Asn Lys 
    1010                 1015                 1020             


Ala Asp  Ala Tyr Glu Pro Ile  Arg Arg Thr Gln Ser  Leu Lys Ala 
    1025                 1030                 1035             


Ile Gln  Gln Leu Glu Lys Asn  Ile Leu Lys Lys Asn  Gly Phe Asn 
    1040                 1045                 1050             


Gly Lys  Gln His Pro Glu Glu  Leu Lys His Asn Gly  Asn Pro Asn 
    1055                 1060                 1065             


Phe Arg  Lys Tyr Ile Ala Asn  Gly Leu Leu Lys His  Arg Thr Asp 
    1070                 1075                 1080             


Ile Arg  Gln Glu Glu Leu Ala  Leu Ile Ser Asp Thr  Glu Phe Gln 
    1085                 1090                 1095             


Glu Ile  Gly Leu Glu Arg Ile  Arg Gln Thr Asn Pro  Leu Ile Gln 
    1100                 1105                 1110             


Lys Ala  Tyr Leu Leu Ile Leu  Leu Arg Asn Lys Phe  Gly His Asn 
    1115                 1120                 1125             


Gln Leu  Pro Asp Gln Glu His  Phe Arg Leu Met Arg  Ser Ile Tyr 
    1130                 1135                 1140             


Pro Tyr  Asn Gln Gln Glu Ser  Tyr Ser Ala Tyr Phe  Asn His Val 
    1145                 1150                 1155             


Ile Thr  Gln Ile Ile Glu Glu  Leu Asn Thr 
    1160                 1165             


<210>  1800
<211>  1140
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1800

Met Glu Asn Asp Gln Gln Ile Leu Glu Asn Arg Arg Arg Thr Leu Ala 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Ser Asn His Leu Ala Thr Ser Phe Glu Gln Lys Ala 
        35                  40                  45              


Leu His Glu Glu Gly Gln Ile Pro Ala Ser Phe Leu Cys Asn Lys Ser 
    50                  55                  60                  


Ile Lys Lys Ile Asn Trp Asn His Val Tyr Ser Lys Ala Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Ile Phe Asp Ala Asp Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Arg Glu Thr Ser Asp Lys Glu Gly Lys Asp Phe Thr Ala Met Asn Glu 
            100                 105                 110         


Thr Leu Lys Leu Val Phe Asp Glu Leu Gln Ala Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Ala Asp Ser Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Val Glu Leu Ala Asp Phe Leu Thr Val Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Ala Asp Asp Asp Tyr 
                165                 170                 175     


Ala Val Val Glu Ser Lys Gln Ile Val Thr Pro Asp Asn Gln Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Ile Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Val Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Leu Ala Tyr Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asp Leu Arg Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Glu 
            260                 265                 270         


Val Ile Thr Glu Glu Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Glu Glu Glu Arg 
    290                 295                 300                 


Glu Lys Ile Leu Asp Glu Ile Asp Tyr Glu Asp Tyr Ile Glu Ser Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg His Ser Asn Arg Phe Pro Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Glu Lys Tyr Asn Lys Gln Phe Asp Gly Glu 
        355                 360                 365             


Ala Thr Glu Arg Lys Val Val Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asn Gln Glu Thr Val Glu Leu Lys Ile Asp Ser Ala 
385                 390                 395                 400 


Gln Arg Thr Asn Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Glu Ala Arg Leu Leu 
            420                 425                 430         


Thr Lys Ala Lys Pro Glu Ser Lys Val Ser Tyr Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Lys Ala Glu Glu Met Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Lys Val Asn Asp Ser Gln Leu Met Asn Met Gln Phe Ile Asp Glu 
                485                 490                 495     


Ile Lys Glu Gln Leu Pro Ala Asp Trp Asn Glu Phe Gly Lys Arg Ser 
            500                 505                 510         


Asp Ser Lys Lys Lys Lys Ala Tyr Thr Asn Ala Ala Arg Gln Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Lys Val Leu Ala Asn Tyr Gln Leu 
    530                 535                 540                 


Asn Asp Lys Gln Val Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Val 
545                 550                 555                 560 


Lys Glu Val Asp Asp Ser Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Met Glu Lys His Lys Val 
            580                 585                 590         


Asp Lys Ser Ala Arg Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Thr Asp Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Tyr 
625                 630                 635                 640 


Ala Asp Asn Glu Lys Lys Ala Thr Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Lys Asp Gly His Pro Phe Leu Ala Asn Ile Asn 
            660                 665                 670         


Leu Arg Gln Ile Arg Lys Thr Ser Gln Leu Tyr Glu Leu Tyr Leu Val 
        675                 680                 685             


Glu Lys Ala Asn Lys Gln Val Lys Lys Met Asn Pro Lys Thr Gln Arg 
    690                 695                 700                 


Thr Asn Asn Val Asp Glu Ser Trp Met Met Lys Ser Phe Tyr Ala Lys 
705                 710                 715                 720 


Glu Trp Asn Glu Glu Met Gly Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Thr Asn Ile Pro Phe Thr Ile Arg Gln Trp Glu Glu Lys 
            740                 745                 750         


Glu Lys His Asn Leu Gln Ala Trp Leu His Asn Ile Thr Lys Gly Lys 
        755                 760                 765             


Thr Ser Lys Asp Gly Lys Lys Ala Val Asp Leu Pro Thr Asn Leu Phe 
    770                 775                 780                 


Asp Asp Thr Leu Cys Glu Leu Leu Arg Glu Ala Leu Ile Asn Glu Gly 
785                 790                 795                 800 


Ile Asp Ala Thr Pro Thr Thr Lys Tyr Asn Glu Leu Leu Lys His Trp 
                805                 810                 815     


Trp Thr Ala Arg Glu Asp Ser Thr Gln Asp Phe Tyr Leu Ser Glu Arg 
            820                 825                 830         


Gln Tyr Asp Ile Tyr Asp Glu Lys Val Cys Phe Thr Ile Asn Ser Ser 
        835                 840                 845             


Ala His Phe Ala Asp Tyr Tyr Ala Pro Ala Leu Ser Lys Ala Tyr Ser 
    850                 855                 860                 


Arg Leu Arg Ala Glu Arg Asp Val Ala Arg Arg Thr Asp Lys Arg Leu 
865                 870                 875                 880 


Pro Pro Val Glu Arg Lys Asp Val Glu Arg Val Phe Lys Asn Thr Ile 
                885                 890                 895     


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
            900                 905                 910         


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asn Gln Gln Gln Leu Lys 
        915                 920                 925             


Leu Ser Lys Met Asp Ser Leu Leu Asn Glu Thr Lys Arg Ile Glu Gln 
    930                 935                 940                 


Val Ile Asn Thr Gln Leu Ser Phe Asp Gln Lys Gly Lys Glu Ile Lys 
945                 950                 955                 960 


Asp Lys Thr Asn Leu Glu Ile Val Lys Thr Ile Val Ala Glu Arg Lys 
                965                 970                 975     


Gln Lys Asn Tyr Thr Glu Met Arg Lys Tyr Val His Asp Arg Arg Leu 
            980                 985                 990         


Pro Glu Leu Phe Glu Tyr Ile Asp  Gly Asn Glu Leu Pro  Leu Asp Met 
        995                 1000                 1005             


Leu Leu  Asn Glu Leu Arg Ala  Tyr Asn Thr Ala Lys  Gln Val Val 
    1010                 1015                 1020             


Phe Asp  Thr Val Phe Ala Leu  Glu Lys Lys Ile Ile  Glu Thr Asp 
    1025                 1030                 1035             


Pro Glu  Gly Leu Lys Gln Leu  Asn Val Ser Lys Asp  Gly Gln Ile 
    1040                 1045                 1050             


Gln Thr  Gly Asn Ile Gln His  Lys Pro Tyr Val Gln  Trp Leu Glu 
    1055                 1060                 1065             


Asn Lys  Gly Leu Ile Thr Asp  Lys Asp Lys Gln Phe  Ile Asn Met 
    1070                 1075                 1080             


Val Arg  Asn Ser Phe Ser His  Asn Gln Phe Pro Gln  Arg Ser Thr 
    1085                 1090                 1095             


Val Glu  Leu Leu Met Pro Val  Trp Gln Asn Thr Asn  Ile Ala Leu 
    1100                 1105                 1110             


Gln Ile  Ala Arg Glu Tyr Gln  Gln Leu Ile Val Asp  Ile Ile Glu 
    1115                 1120                 1125             


Lys Ser  Leu His Pro His Lys  Gln His Gln Met Val  
    1130                 1135                 1140 


<210>  1801
<211>  1094
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1801

Met Glu Ala Asn Glu Gln Asn Gln Glu Asn Arg Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Asn Asn His Ile Ala Ala Asp Phe Gly Gln Ala Val 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ser Gly Phe Leu Cys Asn Lys Glu 
    50                  55                  60                  


Ile Lys Lys Leu Asn Trp Asn His Ile Tyr Ala Lys Thr Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ile Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Val Asn Ser Asp Lys Glu Gly Lys Asp Phe Ala Ala Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Ser Glu Leu Gln Asp Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Glu Asn Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Ala Glu Leu Thr Asp Met Leu Thr Ile Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Thr Asp Ala Asp Tyr 
                165                 170                 175     


Glu Leu Val Glu Thr Lys Gln Val Val Thr Thr Gly Asn Ile Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Met Phe Leu Glu Arg Glu His 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asn Leu Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Gly 
            260                 265                 270         


Val Ile Thr Asp Glu Glu Lys Met Gln Phe Arg Pro Glu Leu Asp Glu 
        275                 280                 285             


Leu Asp Ile Glu Lys Leu Ile Ala Asn Ser Thr Asn Asp Asp Glu Arg 
    290                 295                 300                 


Glu Arg Ile Leu Asp Glu Ile Gly Tyr Glu Glu Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg Tyr Asn Asn Arg Phe Pro Tyr Phe Ala Met Arg 
                325                 330                 335     


Phe Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Arg Tyr Thr Lys Gln Leu Ala Gly Glu 
        355                 360                 365             


Gln Thr Glu Arg Val Val Gln Glu Asn Val Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asp Pro Glu Leu Ile Gln Gln Lys Ile Asp Asn Gln 
385                 390                 395                 400 


Gln Arg Thr Asp Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Ile Ala Ile Leu Ile 
            420                 425                 430         


Pro Lys Ser Lys Pro Glu Ser Lys Val Gly Asn Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Asp Tyr Leu Gln Lys Gly Lys Ala Glu Glu Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Ile Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Leu Lys Leu Pro Ala Asn Trp Asn Glu Phe Ala Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asp Ala Ala Met Glu Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Asp Val Leu Ile Thr Tyr Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Asp Val Glu Asp Asn Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Leu Glu Lys His Lys Leu 
            580                 585                 590         


Asp Lys Ser Val Lys Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Met Val Ser Lys Glu Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Ala Asp Thr Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Val Leu Glu Gly Asp Gly His Pro Phe Leu Thr Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Glu Leu Tyr Met Asn 
        675                 680                 685             


Ala Lys Val Gln Tyr Leu Ile Gln Phe Tyr Lys Pro Ser Lys Asp Lys 
    690                 695                 700                 


Val Asp Lys Arg Gly Arg Pro Thr Thr Glu Val Lys Leu Pro Pro Leu 
705                 710                 715                 720 


Asp Lys Arg Ser Asn Ile Pro Phe Thr Ile Arg Gln Trp Asp Glu Lys 
                725                 730                 735     


Glu Lys Tyr Asn Leu Asn Ala Trp Leu Arg Asn Val Thr Val Gly Lys 
            740                 745                 750         


Asn Thr Lys Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe 
        755                 760                 765             


Asp Glu Thr Leu Cys Asp Leu Leu Ser Gln Gln Leu Asp Ala Arg Thr 
    770                 775                 780                 


Val Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Leu Trp 
785                 790                 795                 800 


Trp Lys Thr Arg Asp Asp Ala Thr Gln Asp Phe Tyr Gln Ser Glu Arg 
                805                 810                 815     


Glu Tyr Asp Ile Tyr Glu Glu Lys Val Glu Phe Lys Ile Asp Ser Ser 
            820                 825                 830         


Gly His Phe Ala Asp Tyr Tyr Lys Lys Ala Leu Ser Lys Ala Tyr Asn 
        835                 840                 845             


Arg Leu Lys Ala Glu Arg Glu Ile Ala Arg Arg Thr Asn Lys Arg Leu 
    850                 855                 860                 


Pro Pro Ile Glu His Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile 
865                 870                 875                 880 


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
                885                 890                 895     


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asp Ser Gly Asn Leu Lys 
            900                 905                 910         


Leu Ser Thr Ile Lys Thr Ser Leu Asn Asn Thr Thr Gln Ile Lys Gln 
        915                 920                 925             


Lys Ile Leu Asn Lys Thr Ile Val Ala Glu Arg Lys Gln Lys Asn Tyr 
    930                 935                 940                 


Thr Glu Leu Arg Lys Tyr Val His Asp Arg Arg Leu Pro Asn Leu Phe 
945                 950                 955                 960 


Glu Tyr Val Glu Ala Asp Glu Ile Leu Leu Glu Trp Leu Leu Asp Glu 
                965                 970                 975     


Leu Met Ala Tyr Asn Ala Ala Lys Gln Gln Val Phe Asp Thr Ile Phe 
            980                 985                 990         


Met Leu Glu Lys Arg Ile Ile Glu  Thr Asp Pro Gln Glu  Leu Lys Ser 
        995                 1000                 1005             


Leu Phe  Thr Asn Glu Lys Gly  Gln Val Gln Thr Gly  Asn Ile Gln 
    1010                 1015                 1020             


His Lys  Pro Tyr Val Gln Trp  Leu Lys Asn Lys Gly  Leu Ile Asn 
    1025                 1030                 1035             


His Asn  Glu Lys Leu Phe Ile  Asn Met Val Arg Asn  Cys Phe Ser 
    1040                 1045                 1050             


His Asn  Gln Phe Pro Gln Arg  Glu Thr Met Glu Leu  Leu Ile Ser 
    1055                 1060                 1065             


Glu Trp  Gly Ala Gly Lys Ile  Ala Thr Gln Ile Leu  Thr Val Tyr 
    1070                 1075                 1080             


Asn Gln  Leu Ile Thr Asn Ile  Ile Asn Lys Ile 
    1085                 1090                 


<210>  1802
<211>  1184
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1802

Met Glu Arg Ile Phe Gly His Cys Cys Pro His His Asp Ser Val Cys 
1               5                   10                  15      


Phe Val Arg Phe Leu Gly Thr Met Val Ser Asn Gln Asp Gly Arg Glu 
            20                  25                  30          


Asn Val Leu Asp Ile Leu Tyr Ile Ala Asp Arg Thr Arg Lys Leu Lys 
        35                  40                  45              


Pro Met Asn Thr Val Pro Ala Ser Glu Asn Lys Gly Gln Ser Arg Thr 
    50                  55                  60                  


Val Glu Asp Asp Pro Gln Tyr Phe Gly Leu Tyr Leu Asn Leu Ala Arg 
65                  70                  75                  80  


Glu Asn Leu Ile Glu Val Glu Ser His Val Arg Ile Lys Phe Gly Lys 
                85                  90                  95      


Lys Lys Leu Asn Glu Glu Ser Leu Lys Gln Ser Leu Leu Cys Asp His 
            100                 105                 110         


Leu Leu Ser Val Asp Arg Trp Thr Lys Val Tyr Gly His Ser Arg Arg 
        115                 120                 125             


Tyr Leu Pro Phe Leu His Tyr Phe Asp Pro Asp Ser Gln Ile Glu Lys 
    130                 135                 140                 


Asp His Asp Ser Lys Thr Gly Val Asp Pro Asp Ser Ala Gln Arg Leu 
145                 150                 155                 160 


Ile Arg Glu Leu Tyr Ser Leu Leu Asp Phe Leu Arg Asn Asp Phe Ser 
                165                 170                 175     


His Asn Arg Leu Asp Gly Thr Thr Phe Glu His Leu Glu Val Ser Pro 
            180                 185                 190         


Asp Ile Ser Ser Phe Ile Thr Gly Thr Tyr Ser Leu Ala Cys Gly Arg 
        195                 200                 205             


Ala Gln Ser Arg Phe Ala Asp Phe Phe Lys Pro Asp Asp Phe Val Leu 
    210                 215                 220                 


Ala Lys Asn Arg Lys Glu Gln Leu Ile Ser Val Ala Asp Gly Lys Glu 
225                 230                 235                 240 


Cys Leu Thr Val Ser Gly Leu Ala Phe Phe Ile Cys Leu Phe Leu Asp 
                245                 250                 255     


Arg Glu Gln Ala Ser Gly Met Leu Ser Arg Ile Arg Gly Phe Lys Arg 
            260                 265                 270         


Thr Asp Glu Asn Trp Ala Arg Ala Val His Glu Thr Phe Cys Asp Leu 
        275                 280                 285             


Cys Ile Arg His Pro His Asp Arg Leu Glu Ser Ser Asn Thr Lys Glu 
    290                 295                 300                 


Ala Leu Leu Leu Asp Met Leu Asn Glu Leu Asn Arg Cys Pro Arg Ile 
305                 310                 315                 320 


Leu Tyr Asp Met Leu Pro Glu Glu Glu Arg Ala Gln Phe Leu Pro Ala 
                325                 330                 335     


Leu Asp Glu Asn Ser Met Asn Asn Leu Ser Glu Asn Ser Leu Asn Glu 
            340                 345                 350         


Glu Ser Arg Leu Leu Trp Asp Gly Ser Ser Asp Trp Ala Glu Ala Leu 
        355                 360                 365             


Thr Lys Arg Ile Arg His Gln Asp Arg Phe Pro Tyr Leu Met Leu Arg 
    370                 375                 380                 


Phe Ile Glu Glu Met Asp Leu Leu Lys Gly Ile Arg Phe Arg Val Asp 
385                 390                 395                 400 


Leu Gly Glu Ile Glu Leu Asp Ser Tyr Ser Lys Lys Val Gly Arg Asn 
                405                 410                 415     


Gly Glu Tyr Asp Arg Thr Ile Thr Asp His Ala Leu Ala Phe Gly Lys 
            420                 425                 430         


Leu Ser Asp Phe Gln Asn Glu Glu Glu Val Ser Arg Met Ile Ser Gly 
        435                 440                 445             


Glu Ala Ser Tyr Pro Val Arg Phe Ser Leu Phe Ala Pro Arg Tyr Ala 
    450                 455                 460                 


Ile Tyr Asp Asn Lys Ile Gly Tyr Cys His Thr Ser Asp Pro Val Tyr 
465                 470                 475                 480 


Pro Lys Ser Lys Thr Gly Glu Lys Arg Ala Leu Ser Asn Pro Arg Ser 
                485                 490                 495     


Met Gly Phe Ile Ser Val His Asp Leu Arg Lys Leu Leu Leu Met Glu 
            500                 505                 510         


Leu Leu Cys Glu Gly Ser Phe Ser Arg Met Gln Ser Asp Phe Leu Arg 
        515                 520                 525             


Lys Ala Asn Arg Ile Leu Asp Glu Thr Ala Glu Gly Lys Leu Gln Phe 
    530                 535                 540                 


Ser Ala Leu Phe Pro Glu Met Arg His Arg Phe Ile Pro Pro Gln Asn 
545                 550                 555                 560 


Pro Lys Ser Lys Asp Arg Arg Glu Lys Ala Glu Thr Thr Leu Glu Lys 
                565                 570                 575     


Tyr Lys Gln Glu Ile Lys Gly Arg Lys Asp Lys Leu Asn Ser Gln Leu 
            580                 585                 590         


Leu Ser Ala Phe Asp Met Asp Gln Arg Gln Leu Pro Ser Arg Leu Leu 
        595                 600                 605             


Asp Glu Trp Met Asn Ile Arg Pro Ala Ser His Ser Val Lys Leu Arg 
    610                 615                 620                 


Thr Tyr Val Lys Gln Leu Asn Glu Asp Cys Arg Leu Arg Leu Gln Lys 
625                 630                 635                 640 


Phe Arg Lys Asp Gly Asp Gly Lys Ala Arg Ala Ile Pro Leu Val Gly 
                645                 650                 655     


Glu Met Ala Thr Phe Leu Ser Gln Asp Ile Val Arg Met Ile Ile Ser 
            660                 665                 670         


Glu Glu Thr Lys Lys Leu Ile Thr Ser Ala Tyr Tyr Asn Glu Met Gln 
        675                 680                 685             


Arg Ser Leu Ala Gln Tyr Ala Gly Glu Glu Asn Arg His Gln Phe Arg 
    690                 695                 700                 


Ala Ile Val Ala Glu Leu Arg Leu Leu Asp Pro Ser Ser Gly His Pro 
705                 710                 715                 720 


Phe Leu Ser Ala Thr Met Glu Thr Ala His Arg Tyr Thr Glu Asp Phe 
                725                 730                 735     


Tyr Lys Cys Tyr Leu Glu Lys Lys Arg Glu Trp Leu Ala Lys Thr Phe 
            740                 745                 750         


Tyr Arg Pro Glu Gln Asp Glu Asn Thr Lys Arg Arg Ile Ser Val Phe 
        755                 760                 765             


Phe Val Pro Asp Gly Glu Ala Arg Lys Leu Leu Pro Leu Leu Ile Arg 
    770                 775                 780                 


Arg Arg Met Lys Glu Gln Asn Asp Leu Gln Asp Trp Ile Arg Asn Lys 
785                 790                 795                 800 


Gln Ala His Pro Ile Asp Leu Pro Ser His Leu Phe Asp Ser Lys Val 
                805                 810                 815     


Met Glu Leu Leu Lys Val Lys Asp Gly Lys Lys Lys Trp Asn Glu Ala 
            820                 825                 830         


Phe Lys Asp Trp Trp Ser Thr Lys Tyr Pro Asp Gly Met Gln Pro Phe 
        835                 840                 845             


Tyr Gly Leu Arg Arg Glu Leu Asn Ile His Gly Lys Ser Val Ser Tyr 
    850                 855                 860                 


Ile Pro Ser Asp Gly Lys Lys Phe Ala Asp Cys Tyr Thr His Leu Met 
865                 870                 875                 880 


Glu Lys Thr Val Arg Asp Lys Lys Arg Glu Leu Arg Thr Ala Gly Lys 
                885                 890                 895     


Pro Val Pro Pro Asp Leu Ala Ala Tyr Ile Lys Arg Ser Phe His Arg 
            900                 905                 910         


Ala Val Asn Glu Arg Glu Phe Met Leu Arg Leu Val Gln Glu Asp Asp 
        915                 920                 925             


Arg Leu Met Leu Met Ala Ile Asn Lys Ile Met Thr Asp Arg Glu Glu 
    930                 935                 940                 


Asp Ile Leu Pro Gly Leu Lys Asn Ile Asp Ser Ile Leu Asp Lys Glu 
945                 950                 955                 960 


Asn Gln Phe Ser Leu Ala Val His Ala Lys Val Leu Glu Lys Glu Gly 
                965                 970                 975     


Glu Gly Gly Asp Asn Ser Leu Ser Leu Val Pro Ala Thr Ile Glu Ile 
            980                 985                 990         


Lys Ser Lys Arg Lys Asp Trp Ser  Lys Tyr Ile Arg Tyr  Arg Tyr Asp 
        995                 1000                 1005             


Arg Arg  Val Pro Gly Leu Met  Ser His Phe Pro Glu  His Lys Ala 
    1010                 1015                 1020             


Thr Leu  Asp Glu Val Lys Thr  Leu Leu Gly Glu Tyr  Asp Arg Cys 
    1025                 1030                 1035             


Arg Ile  Lys Ile Phe Asp Trp  Ala Phe Ala Leu Glu  Gly Ala Ile 
    1040                 1045                 1050             


Met Ser  Asp Arg Asp Leu Lys  Pro Tyr Leu His Glu  Ser Ser Ser 
    1055                 1060                 1065             


Arg Glu  Gly Lys Ser Gly Glu  His Ser Thr Leu Val  Lys Met Leu 
    1070                 1075                 1080             


Val Glu  Lys Lys Gly Cys Leu  Thr Pro Asp Glu Ser  Gln Tyr Leu 
    1085                 1090                 1095             


Ile Leu  Ile Arg Asn Lys Ala  Ala His Asn Gln Phe  Pro Cys Ala 
    1100                 1105                 1110             


Ala Glu  Ile Pro Leu Ile Tyr  Arg Asp Val Ser Ala  Lys Val Gly 
    1115                 1120                 1125             


Ser Ile  Glu Gly Ser Ser Ala  Lys Asp Leu Pro Glu  Gly Ser Ser 
    1130                 1135                 1140             


Leu Val  Asp Ser Leu Trp Lys  Lys Tyr Glu Met Ile  Ile Arg Lys 
    1145                 1150                 1155             


Ile Leu  Pro Ile Leu Asp Pro  Glu Asn Arg Phe Phe  Gly Lys Leu 
    1160                 1165                 1170             


Leu Asn  Asn Met Ser Gln Pro  Ile Asn Asp Leu 
    1175                 1180                 


<210>  1803
<211>  1141
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1803

Met Glu Asp Asp Lys Lys Thr Lys Glu Ser Thr Asn Met Leu Asp Asn 
1               5                   10                  15      


Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val Tyr 
            20                  25                  30          


Ile Thr Val Asn His Ile Asn Lys Val Leu Glu Leu Lys Asn Lys Lys 
        35                  40                  45              


Asp Gln Asp Ile Ile Ile Asp Asn Asp Gln Asp Ile Leu Ala Ile Lys 
    50                  55                  60                  


Thr His Trp Glu Lys Val Asn Gly Asp Leu Asn Lys Thr Glu Arg Leu 
65                  70                  75                  80  


Arg Glu Leu Met Thr Lys His Phe Pro Phe Leu Glu Thr Ala Ile Tyr 
                85                  90                  95      


Thr Lys Asn Lys Glu Asp Lys Glu Glu Val Lys Gln Glu Lys Gln Ala 
            100                 105                 110         


Lys Ala Gln Ser Phe Asp Ser Leu Lys His Cys Leu Phe Leu Phe Leu 
        115                 120                 125             


Glu Lys Leu Gln Glu Ala Arg Asn Tyr Tyr Ser His Tyr Lys Tyr Ser 
    130                 135                 140                 


Glu Ser Thr Lys Glu Pro Met Leu Glu Lys Glu Leu Leu Lys Lys Met 
145                 150                 155                 160 


Tyr Asn Ile Phe Asp Asp Asn Ile Arg Leu Val Ile Lys Asp Tyr Gln 
                165                 170                 175     


His Asn Lys Asp Ile Asn Pro Asp Glu Asp Phe Lys His Leu Asp Arg 
            180                 185                 190         


Ile Glu Glu Asp Phe Asn Tyr Tyr Phe Thr Arg Asn Lys Lys Gly Asn 
        195                 200                 205             


Ile Thr Ala Ser Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys 
    210                 215                 220                 


Lys Asp Ala Ile Trp Met Gln Gln Lys Leu Arg Gly Phe Lys Asp Asn 
225                 230                 235                 240 


Arg Glu Ser Lys Lys Lys Met Thr His Glu Val Phe Cys Arg Ser Arg 
                245                 250                 255     


Met Leu Leu Pro Lys Leu Arg Leu Glu Ser Thr Gln Thr Gln Asp Trp 
            260                 265                 270         


Ile Leu Leu Asp Met Leu Asn Glu Leu Ile Arg Cys Pro Lys Ser Leu 
        275                 280                 285             


Tyr Glu Arg Leu Gln Gly Glu Asp Arg Glu Lys Phe Lys Val Pro Phe 
    290                 295                 300                 


Asp Pro Ala Asp Glu Asp Tyr Asp Ala Glu Gln Glu Pro Phe Lys Asn 
305                 310                 315                 320 


Thr Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr 
                325                 330                 335     


Phe Asp Tyr Asn Glu Ile Phe Thr Asn Leu Arg Phe Gln Ile Asp Leu 
            340                 345                 350         


Gly Thr Tyr His Phe Ser Ile Tyr Lys Lys Leu Ile Gly Gly Gln Lys 
        355                 360                 365             


Glu Asp Arg His Leu Thr His Lys Leu Tyr Gly Phe Glu Arg Ile Gln 
    370                 375                 380                 


Glu Phe Ala Lys Gln Asn Arg Pro Asp Glu Trp Lys Ala Ile Val Lys 
385                 390                 395                 400 


Asp Leu Asp Thr Tyr Glu Thr Ser Asn Glu Arg Tyr Ile Ser Glu Thr 
                405                 410                 415     


Thr Pro His Tyr His Leu Glu Asn Gln Lys Ile Gly Ile Arg Phe Arg 
            420                 425                 430         


Asn Asp Asn Asp Glu Ile Trp Pro Ser Leu Lys Thr Asn Gly Glu Asn 
        435                 440                 445             


Asn Glu Lys Arg Lys Tyr Lys Leu Asp Lys Gln Tyr Gln Ala Glu Ala 
    450                 455                 460                 


Phe Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu 
465                 470                 475                 480 


Leu Lys Met Glu Asn Thr Asp Asn Gly Lys Glu Asn Asn Glu Val Gly 
                485                 490                 495     


Thr Lys Lys Lys Arg Asn Lys Asn Asn Glu Gln Glu Lys His Lys Ile 
            500                 505                 510         


Glu Glu Ile Ile Glu Asn Lys Ile Lys Asp Ile Tyr Ala Leu Tyr Asp 
        515                 520                 525             


Ala Phe Ala Asn Gly Glu Ile Asn Ser Glu Glu Glu Leu Lys Glu Tyr 
    530                 535                 540                 


Leu Lys Gly Lys Asp Ile Glu Ile Val His Leu Pro Lys Gln Met Val 
545                 550                 555                 560 


Ala Ile Leu Tyr Asp Glu His Lys Asp Met Val Glu Glu Ala Lys Arg 
                565                 570                 575     


Lys Gln Lys Glu Met Val Lys Asp Thr Lys Lys Leu Leu Ala Ala Leu 
            580                 585                 590         


Glu Lys Gln Thr Gln Gly Glu Ile Glu Asp Gly Gly Arg Asn Ile Arg 
        595                 600                 605             


Leu Leu Lys Ser Gly Glu Ile Ala Arg Trp Leu Val Asn Asp Met Met 
    610                 615                 620                 


Arg Phe Gln Pro Val Gln Lys Asp Asn Glu Gly Asn Pro Leu Asn Asn 
625                 630                 635                 640 


Ser Lys Ala Asn Ser Thr Glu Tyr Gln Met Leu Gln Arg Ser Leu Ala 
                645                 650                 655     


Leu Tyr Asn Lys Glu Glu Lys Pro Thr Arg Tyr Phe Arg Gln Val Asn 
            660                 665                 670         


Leu Ile Asn Ser Ser Asn Pro His Pro Phe Leu Lys Trp Thr Lys Trp 
        675                 680                 685             


Glu Glu Cys Asn Asn Ile Leu Ser Phe Tyr Arg Asn Tyr Leu Thr Lys 
    690                 695                 700                 


Lys Ile Glu Phe Leu Asn Lys Leu Lys Pro Glu Asp Trp Glu Lys Asn 
705                 710                 715                 720 


Gln Tyr Phe Leu Lys Leu Lys Glu Pro Lys Thr Asn Arg Glu Thr Leu 
                725                 730                 735     


Val Gln Gly Trp Lys Asn Gly Phe Asn Leu Pro Arg Gly Ile Phe Thr 
            740                 745                 750         


Glu Pro Ile Arg Glu Trp Phe Lys Arg His Gln Asn Asp Ser Glu Glu 
        755                 760                 765             


Tyr Lys Lys Val Glu Ala Leu Asp Arg Val Gly Leu Val Thr Lys Val 
    770                 775                 780                 


Ile Pro Leu Phe Phe Lys Lys Glu Asp Leu Lys Lys Asp Ala Gln Lys 
785                 790                 795                 800 


Glu Ile Asn Asn Cys Val Gln Pro Phe Tyr Ser Phe Pro Tyr Asn Val 
                805                 810                 815     


Gly Asn Ile His Lys Pro Asp Glu Lys Asp Phe Leu His Arg Glu Glu 
            820                 825                 830         


Arg Ile Glu Leu Trp Asp Lys Lys Lys Asp Lys Phe Lys Gly Tyr Lys 
        835                 840                 845             


Ala Lys Val Lys Ser Lys Lys Leu Thr Asp Lys Glu Lys Glu Glu Tyr 
    850                 855                 860                 


Arg Ser Tyr Leu Glu Phe Gln Ser Trp Asn Lys Phe Glu Arg Glu Leu 
865                 870                 875                 880 


Arg Leu Val Arg Asn Gln Asp Ile Val Thr Trp Leu Leu Cys Thr Glu 
                885                 890                 895     


Leu Ile Asp Lys Leu Lys Val Glu Gly Leu Asn Val Glu Glu Leu Lys 
            900                 905                 910         


Lys Leu Arg Leu Lys Asp Ile Asp Thr Asp Thr Ala Lys Lys Glu Lys 
        915                 920                 925             


Asn Asn Ile Leu Asn Arg Ile Met Pro Met Gln Leu Pro Val Thr Val 
    930                 935                 940                 


Tyr Glu Ile Asp Asp Ser His Asn Ile Val Lys Asp Arg Pro Leu His 
945                 950                 955                 960 


Thr Val Tyr Ile Glu Glu Thr Lys Thr Lys Leu Leu Lys Gln Gly Asn 
                965                 970                 975     


Phe Lys Ala Leu Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe 
            980                 985                 990         


Val Asp Thr Ser Ser Lys Ala Glu  Leu Lys Asp Lys Pro  Ile Ser Lys 
        995                 1000                 1005             


Ser Val  Val Glu Tyr Glu Leu  Gly Glu Tyr Gln Asn  Ala Arg Ile 
    1010                 1015                 1020             


Glu Thr  Ile Lys Asp Met Leu  Leu Leu Glu Lys Thr  Leu Ile Lys 
    1025                 1030                 1035             


Lys Tyr  Lys Lys Leu Pro Thr  Asp Asn Phe Ser Asp  Met Leu Asn 
    1040                 1045                 1050             


Gly Trp  Leu Glu Gly Lys Asp  Glu Ser Asp Lys Ala  Arg Phe Gln 
    1055                 1060                 1065             


Asn Asp  Val Lys Leu Leu Val  Ala Val Arg Asn Ala  Phe Ser His 
    1070                 1075                 1080             


Asn Gln  Tyr Pro Met Arg Asn  Arg Ile Ala Phe Ala  Asn Ile Asn 
    1085                 1090                 1095             


Pro Phe  Ser Leu Ser Ser Ala  Asp Thr Ser Glu Glu  Lys Lys Leu 
    1100                 1105                 1110             


Asp Ile  Ala Asn Gln Leu Lys  Asp Lys Thr His Lys  Ile Ile Lys 
    1115                 1120                 1125             


Lys Ile  Ile Glu Ile Glu Lys  Pro Ile Glu Thr Lys  Glu 
    1130                 1135                 1140     


<210>  1804
<211>  1317
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1804

Met Gly Asn Asp Tyr Lys Lys Gly Asn Tyr Thr Pro Lys Asn Gln Asn 
1               5                   10                  15      


Gly Asn Lys Gln Gln Pro Lys Lys Val Arg Arg Leu Gln Lys Thr Asn 
            20                  25                  30          


Phe Arg Ile Ser Leu Thr Gly Lys His Val Phe Gly Ala Tyr Phe Asn 
        35                  40                  45              


Met Ala Arg Thr Asn Phe Ile Lys Thr Ile Asn Tyr Ile Leu Pro Ile 
    50                  55                  60                  


Ala Gly Val Arg Gly Asn Tyr Ser Glu Ser Gln Ile Asn Lys Leu Leu 
65                  70                  75                  80  


Gln Ala Met Phe Leu Ile Gln Thr Gly Arg Asn Gly Glu Leu Thr Lys 
                85                  90                  95      


Glu Gln Lys Gln Trp Glu Lys Lys Leu Arg Leu Asn Pro Glu Gln Gln 
            100                 105                 110         


Thr Lys Leu Gln Gln Leu Leu Phe Lys His Phe Pro Val Leu Gly Pro 
        115                 120                 125             


Met Met Ala Asp Val Ala Asp His Lys Val Tyr Leu Asn Lys Lys Lys 
    130                 135                 140                 


Ser Asn Val Gln Thr Asp Asp Glu Ala Phe Ala Gln Leu Lys Gly Val 
145                 150                 155                 160 


Ser Leu Ala Asp Cys Leu Asp Met Ile Tyr Leu Met Ala Glu Thr Leu 
                165                 170                 175     


Thr Glu Cys Arg Asn Phe Tyr Thr His Lys Ser Pro Tyr Asn Thr Pro 
            180                 185                 190         


Ser Gln Leu Ala Met Gln Tyr Gln His Gln Glu Lys Ile Ala Gln Lys 
        195                 200                 205             


Leu Asp Lys Val Val Val Ala Ser Arg Arg Ile Leu Lys Asp Arg Glu 
    210                 215                 220                 


Gly Leu Ser Val Asn Glu Val Glu Phe Leu Thr Gly Ile Asp His Leu 
225                 230                 235                 240 


His Gln Glu Thr Val Lys Asp Glu Phe Gly Asn Val Lys Met Lys Gly 
                245                 250                 255     


Gly Lys Val Met Lys Thr Phe Val Glu Tyr Asp Asp Phe Tyr Phe Lys 
            260                 265                 270         


Ile Ser Gly Lys Arg Leu Val Lys Gly Tyr Thr Val Thr Val Lys Asp 
        275                 280                 285             


Asp Lys Pro Val Asn Val Asp Thr Met Leu Pro Ala Leu Ser Asp Phe 
    290                 295                 300                 


Gly Leu Leu Tyr Phe Cys Val Ile Phe Leu Ser Lys Pro Tyr Ala Lys 
305                 310                 315                 320 


Leu Phe Ile Asp Glu Val Arg Leu Phe Glu Phe Ser Pro Phe Ser Asp 
                325                 330                 335     


Asn Glu Asn Met Ile Met Ser Glu Met Leu Ser Ile Tyr Arg Ile Arg 
            340                 345                 350         


Thr Pro Arg Leu His Lys Ile Asp Ser Arg Asp Ser Lys Ala Thr Leu 
        355                 360                 365             


Ala Met Asp Ile Phe Gly Glu Leu Arg Arg Cys Pro Ile Glu Leu Tyr 
    370                 375                 380                 


Asp Leu Leu Asp Lys Asn Ser Gly Gln Pro Phe Phe His Asp Glu Val 
385                 390                 395                 400 


Lys Arg Pro Asn Ser His Thr Pro Glu Val Ser Lys Arg Leu Arg Tyr 
                405                 410                 415     


Asn Asp Arg Phe Pro Thr Leu Ala Leu Arg Tyr Val Asp Glu Thr Glu 
            420                 425                 430         


Leu Phe Lys Arg Ile Arg Phe Gln Leu Gln Leu Gly Ala Phe Arg Tyr 
        435                 440                 445             


Lys Phe Tyr Asp Lys Glu Gly Ile Asp Gly Arg Ile Arg Val Arg Arg 
    450                 455                 460                 


Ile Gln Lys Asp Ile Asn Gly Tyr Gly Arg Leu Gln Glu Val Ala Asp 
465                 470                 475                 480 


Lys Arg Ile Glu Lys Trp Gly Asp Met Leu Gln Lys Arg Glu Glu Arg 
                485                 490                 495     


Ser Val Lys Leu Glu His Glu Glu Leu Tyr Ile Asp Leu Asp Gln Phe 
            500                 505                 510         


Gln Glu Asp Thr Ala Asp Ser Thr Pro Tyr Val Thr Asp Arg Arg Pro 
        515                 520                 525             


Ala Tyr Asn Ile His Ala Asn Arg Ile Gly Leu Tyr Trp Glu Glu Ser 
    530                 535                 540                 


Gln Asn Pro Asn Glu Phe Lys Val Phe Asp Asn Asn Gly Met Tyr Ile 
545                 550                 555                 560 


Pro Glu Leu Val Val Thr Glu Asp Glu Lys Ala Pro Val Lys Met Pro 
                565                 570                 575     


Ala Pro Arg Cys Ala Leu Ser Val Tyr Asp Leu Ser Ala Met Leu Phe 
            580                 585                 590         


Tyr Glu Tyr Leu Arg Glu Gln Glu Asp Gly Asn Thr Pro Ser Ala Glu 
        595                 600                 605             


Gln Ile Ile Ile Asp Tyr Glu Ala Asp Tyr Arg Arg Phe Phe Asn Ala 
    610                 615                 620                 


Val Ala Glu Gly Thr Leu Lys Pro Phe Gln Lys Thr Lys Glu Phe Arg 
625                 630                 635                 640 


Glu Tyr Leu Glu Lys Glu Tyr Pro Arg Leu Arg Met Ala Asp Ile Pro 
                645                 650                 655     


Glu Lys Leu Gln Leu Tyr Leu Thr Cys Lys Gly Leu Thr His Asp Asn 
            660                 665                 670         


Lys Pro Glu Thr Val Arg Glu Arg Leu Ile Arg Leu Ala Ile Glu His 
        675                 680                 685             


Leu Lys Glu Arg Glu Glu Arg Val Gln Arg Arg Leu Glu His Tyr Glu 
    690                 695                 700                 


Glu Asp Arg Lys Met Ile Gly Glu Lys Asp Asn Lys Tyr Gly Lys Lys 
705                 710                 715                 720 


Gly Phe Ala Asp Val Arg His Gly Ala Ile Ala Arg Tyr Leu Ala Gln 
                725                 730                 735     


Ser Met Met Glu Trp Gln Pro Thr Asn Leu Lys Asp Lys Glu Lys Gly 
            740                 745                 750         


Arg Asp Lys Leu Thr Gly Met Asn Tyr Asn Val Leu Thr Ala Tyr Leu 
        755                 760                 765             


Ala Thr Phe Gly Gln Pro Gln Thr Pro Glu Glu Asp Phe Thr Pro Arg 
    770                 775                 780                 


Thr Leu Glu Gln Val Leu Thr Gly Ala His Leu Ile Gly Gly Asn Asn 
785                 790                 795                 800 


Pro His Pro Phe Ile Asp Lys Val Leu Ala Leu Gly Asn Arg Asn Ile 
                805                 810                 815     


Glu Glu Leu Tyr Leu His Tyr Leu Glu Glu Glu Leu Lys His Ile Arg 
            820                 825                 830         


Ser Arg Lys Gln Ser Leu Ser Ser Asn Pro Ser Asp Lys Ala Leu Ser 
        835                 840                 845             


Ala Leu Pro Phe Val His His Asp Arg Leu Arg Phe His Glu Arg Thr 
    850                 855                 860                 


Asn Glu Glu Met Lys Ala Leu Ala Ala Arg Tyr Thr Thr Ile Gln Leu 
865                 870                 875                 880 


Pro Asp Gly Leu Phe Thr Pro Tyr Ile Val Glu Leu Leu Lys Gln Tyr 
                885                 890                 895     


Val Glu Leu Gln Thr Ala Leu Asn Gln Asp Ile Pro Ala Asn Leu Asn 
            900                 905                 910         


Pro Thr Asn Asn Ala Ala Tyr Leu Ile Thr Gln Phe Tyr Gln Thr Val 
        915                 920                 925             


Leu Lys Asp Asp Ala Gln Pro Phe Tyr Ile Ser Gly Lys Thr Tyr Thr 
    930                 935                 940                 


Arg His Lys Glu Gly Glu Lys Asp Glu Val Phe Ser Phe Lys Arg Ala 
945                 950                 955                 960 


Tyr Glu Leu Phe Ser Val Leu Asn Asn Glu Lys Lys Arg Thr Phe Pro 
                965                 970                 975     


Phe Glu Leu Ile Pro Leu Phe Leu Thr Ser Glu Glu Ile Gln Lys Arg 
            980                 985                 990         


Leu Ser Glu Lys Leu Leu Asp Asp  Asp Gly Asn Pro Met  Pro Glu Gln 
        995                 1000                 1005             


Gly Lys  Arg Gly Lys Ala Ala  Thr Asp Ser Gln Gly  Asn Ile Ile 
    1010                 1015                 1020             


Trp Gln  Arg Lys Ile Lys Leu  Asp Ile Ser Asn Tyr  Val Ser Ser 
    1025                 1030                 1035             


Leu Ser  Asp Lys Asp Leu Lys  Ile Ser Met Asn Gln  Ser Trp Lys 
    1040                 1045                 1050             


Gln Lys  Glu Glu Glu Arg Thr  Glu Lys Arg Glu Ala  Leu Gln Ser 
    1055                 1060                 1065             


Arg Leu  Thr Arg Gln Ile His  Asp Ile Lys Tyr Asn  Glu Arg Thr 
    1070                 1075                 1080             


Leu Arg  Arg Tyr Lys Thr Gln  Asp Met Val Leu Phe  Leu Ile Ala 
    1085                 1090                 1095             


Lys Lys  Leu Phe Glu Asn Ile  Ile Phe Glu Gln Gly  Asn Glu Val 
    1100                 1105                 1110             


Asn Ser  Glu Gln Met Arg Leu  Ser Lys Val Cys Asp  Glu Ala Phe 
    1115                 1120                 1125             


Leu Arg  Gln Thr Leu Thr Phe  Arg Val Pro Val Thr  Val Gly Asp 
    1130                 1135                 1140             


Lys Thr  Ile Tyr Val Glu Gln  Glu Asn Met Ser Leu  Lys Asn Tyr 
    1145                 1150                 1155             


Gly Glu  Phe Tyr Arg Phe Leu  Thr Asp Asp Arg Leu  Met Ser Leu 
    1160                 1165                 1170             


Leu Glu  Asn Ile Ile Gly Thr  Leu Lys Pro Asn Glu  Asp Gly Asp 
    1175                 1180                 1185             


Leu Val  Ile Arg His Thr Asp  Leu Met Ser Glu Leu  Ala Ala Tyr 
    1190                 1195                 1200             


Asp Gln  His Arg Ser Thr Val  Phe Lys Leu Ile Gln  Gln Ile Glu 
    1205                 1210                 1215             


Asn Leu  Ile Ile Glu Lys Asn  Asn Ala Leu Lys Asn  Pro Asp Ser 
    1220                 1225                 1230             


Glu Asp  Phe Trp Val Lys Glu  Gly Leu Pro Lys Arg  Asn Asn Phe 
    1235                 1240                 1245             


Ala Ser  Leu Leu Glu Leu Ile  Asp Gln Leu Asn Asn  Val Ala Leu 
    1250                 1255                 1260             


Thr Asp  Glu Glu Arg Lys Leu  Leu Val Ala Ile Arg  Asn Ala Phe 
    1265                 1270                 1275             


Ser His  Asn Ser Tyr Asn Ile  Asp Phe Ser Leu Ile  Lys Asp Val 
    1280                 1285                 1290             


Lys His  Leu Pro Glu Val Ala  Lys Gly Ile Leu Gln  His Leu Gln 
    1295                 1300                 1305             


Leu Val  Leu Gly Val Glu Gln  Thr Lys 
    1310                 1315         


<210>  1805
<211>  1134
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1805

Val Lys Met Glu Asp Asp Lys Lys Thr Lys Glu Ser Thr Asn Met Leu 
1               5                   10                  15      


Asp Asn Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Val Tyr Ile Thr Val Asn His Ile Asn Lys Val Leu Glu Leu Lys Asn 
        35                  40                  45              


Lys Lys Asp Gln Asp Ile Ile Ile Asp Asn Asp Gln Asp Ile Leu Ala 
    50                  55                  60                  


Ile Lys Thr His Trp Glu Lys Val Asn Gly Asp Leu Asn Lys Thr Glu 
65                  70                  75                  80  


Arg Leu Arg Glu Leu Met Thr Lys His Phe Pro Phe Leu Glu Thr Ala 
                85                  90                  95      


Ile Tyr Thr Lys Asn Lys Glu Asp Lys Glu Glu Val Lys Gln Glu Lys 
            100                 105                 110         


Gln Ala Lys Ala Gln Ser Phe Asp Ser Leu Lys His Cys Leu Phe Leu 
        115                 120                 125             


Phe Leu Glu Lys Leu Gln Glu Ala Arg Asn Tyr Tyr Ser His Tyr Lys 
    130                 135                 140                 


Tyr Ser Glu Ser Thr Lys Glu Pro Met Leu Glu Lys Glu Leu Leu Lys 
145                 150                 155                 160 


Lys Met Tyr Asn Ile Phe Asp Asp Asn Ile Gln Leu Val Ile Lys Asp 
                165                 170                 175     


Tyr Gln His Asn Lys Asp Ile Asn Pro Asp Glu Asp Phe Lys His Leu 
            180                 185                 190         


Asp Arg Thr Glu Glu Glu Phe Asn Tyr Tyr Phe Thr Thr Asn Lys Lys 
        195                 200                 205             


Gly Asn Ile Thr Ala Ser Gly Leu Leu Phe Phe Val Ser Leu Phe Leu 
    210                 215                 220                 


Glu Lys Lys Asp Ala Ile Trp Met Gln Gln Lys Leu Arg Gly Phe Lys 
225                 230                 235                 240 


Asp Asn Arg Glu Ser Lys Lys Lys Met Thr His Glu Val Phe Cys Arg 
                245                 250                 255     


Ser Arg Met Leu Leu Pro Lys Leu Arg Leu Glu Ser Thr Gln Thr Gln 
            260                 265                 270         


Asp Trp Ile Leu Leu Asp Met Leu Asn Glu Leu Ile Arg Cys Pro Lys 
        275                 280                 285             


Ser Leu Tyr Glu Arg Leu Gln Gly Glu Tyr Arg Lys Lys Phe Asn Val 
    290                 295                 300                 


Pro Phe Asp Ser Ala Asp Glu Asp Tyr Asp Ala Glu Gln Glu Pro Phe 
305                 310                 315                 320 


Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Ala Leu 
                325                 330                 335     


Arg Tyr Phe Asp Tyr Asn Glu Ile Phe Thr Asn Leu Arg Phe Gln Ile 
            340                 345                 350         


Asp Leu Gly Thr Tyr His Phe Ser Ile Tyr Lys Lys Leu Ile Gly Gly 
        355                 360                 365             


Gln Lys Glu Asp Arg His Leu Thr His Lys Leu Tyr Gly Phe Glu Arg 
    370                 375                 380                 


Ile Gln Glu Phe Ala Lys Gln Asn Arg Thr Asp Glu Trp Lys Ala Ile 
385                 390                 395                 400 


Val Lys Asp Phe Asp Thr Tyr Glu Thr Ser Glu Glu Pro Tyr Ile Ser 
                405                 410                 415     


Glu Thr Ala Pro His Tyr His Leu Glu Asn Gln Lys Ile Gly Ile Arg 
            420                 425                 430         


Phe Arg Asn Asp Asn Asp Glu Ile Trp Pro Ser Leu Lys Thr Asn Gly 
        435                 440                 445             


Glu Asn Asn Glu Lys Arg Lys Tyr Lys Leu Asp Lys Gln Tyr Gln Ala 
    450                 455                 460                 


Glu Ala Phe Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr 
465                 470                 475                 480 


Leu Leu Leu Lys Lys Glu Glu Pro Asn Asn Asp Lys Lys Asn Ala Ser 
                485                 490                 495     


Ile Val Glu Gly Phe Ile Lys Arg Glu Ile Arg Asp Ile Tyr Lys Leu 
            500                 505                 510         


Tyr Asp Ala Phe Ala Asn Gly Glu Ile Asn Asn Ile Asp Asp Leu Glu 
        515                 520                 525             


Lys Tyr Cys Glu Asp Lys Gly Ile Pro Lys Arg His Leu Pro Lys Gln 
    530                 535                 540                 


Met Val Ala Ile Leu Tyr Asp Glu His Lys Asp Met Ala Glu Glu Ala 
545                 550                 555                 560 


Lys Arg Lys Gln Lys Glu Met Val Lys Asp Thr Lys Lys Leu Leu Ala 
                565                 570                 575     


Thr Leu Glu Lys Gln Thr Gln Gly Glu Ile Glu Asp Gly Gly Arg Asn 
            580                 585                 590         


Ile Arg Leu Leu Lys Ser Gly Glu Ile Ala Arg Trp Leu Val Asn Asp 
        595                 600                 605             


Met Met Arg Phe Gln Pro Val Gln Lys Asp Asn Glu Gly Asn Pro Leu 
    610                 615                 620                 


Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln Met Leu Gln Arg Ser 
625                 630                 635                 640 


Leu Ala Leu Tyr Asn Lys Glu Glu Lys Pro Thr Arg Tyr Phe Arg Gln 
                645                 650                 655     


Val Asn Leu Ile Asn Ser Ser Asn Pro His Pro Phe Leu Lys Trp Thr 
            660                 665                 670         


Lys Trp Glu Glu Cys Asn Asn Ile Leu Ser Phe Tyr Arg Ser Tyr Leu 
        675                 680                 685             


Thr Lys Lys Ile Glu Phe Leu Asn Lys Leu Lys Pro Glu Asp Trp Glu 
    690                 695                 700                 


Lys Asn Gln Tyr Phe Leu Lys Leu Lys Glu Pro Lys Thr Asn Arg Glu 
705                 710                 715                 720 


Thr Leu Val Gln Gly Trp Lys Asn Gly Phe Asn Leu Pro Arg Gly Ile 
                725                 730                 735     


Phe Thr Glu Pro Ile Arg Glu Trp Phe Lys Arg His Gln Asn Asp Ser 
            740                 745                 750         


Glu Glu Tyr Glu Lys Val Glu Thr Leu Asp Arg Val Gly Leu Val Thr 
        755                 760                 765             


Lys Val Ile Pro Leu Phe Phe Lys Lys Glu Asp Ser Lys Asp Lys Glu 
    770                 775                 780                 


Glu Tyr Leu Lys Lys Asp Ala Gln Lys Glu Ile Asn Asn Cys Val Gln 
785                 790                 795                 800 


Pro Phe Tyr Gly Phe Pro Tyr Asn Val Gly Asn Ile His Lys Pro Asp 
                805                 810                 815     


Glu Lys Asp Phe Leu Pro Ser Glu Glu Arg Lys Lys Leu Trp Gly Asp 
            820                 825                 830         


Lys Lys Tyr Lys Phe Lys Gly Tyr Lys Ala Lys Val Lys Ser Lys Lys 
        835                 840                 845             


Leu Thr Asp Lys Glu Lys Glu Glu Tyr Arg Ser Tyr Leu Glu Phe Gln 
    850                 855                 860                 


Ser Trp Asn Lys Phe Glu Arg Glu Leu Arg Leu Val Arg Asn Gln Asp 
865                 870                 875                 880 


Ile Val Thr Trp Leu Leu Cys Thr Glu Leu Ile Asp Lys Leu Lys Val 
                885                 890                 895     


Glu Gly Leu Asn Val Glu Glu Leu Lys Lys Leu Arg Leu Lys Asp Ile 
            900                 905                 910         


Asp Thr Asp Thr Ala Lys Gln Glu Lys Asn Asn Ile Leu Asn Arg Val 
        915                 920                 925             


Met Pro Met Gln Leu Pro Val Thr Val Tyr Glu Ile Asp Asp Ser His 
    930                 935                 940                 


Asn Ile Val Lys Asp Arg Pro Leu His Thr Val Tyr Ile Glu Glu Thr 
945                 950                 955                 960 


Lys Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys Asp 
                965                 970                 975     


Arg Arg Leu Asn Gly Leu Phe Ser Phe Val Asp Thr Ser Ser Glu Thr 
            980                 985                 990         


Glu Leu Lys Ser Asn Pro Ile Ser  Lys Ser Leu Val Glu  Tyr Glu Leu 
        995                 1000                 1005             


Gly Glu  Tyr Gln Asn Ala Arg  Ile Glu Thr Ile Lys  Asp Met Leu 
    1010                 1015                 1020             


Leu Leu  Glu Glu Thr Leu Ile  Glu Lys Tyr Lys Thr  Leu Pro Thr 
    1025                 1030                 1035             


Asp Asn  Phe Ser Asp Met Leu  Asn Gly Trp Leu Glu  Gly Lys Asp 
    1040                 1045                 1050             


Glu Ala  Asp Lys Ala Arg Phe  Gln Asn Asp Val Lys  Leu Leu Val 
    1055                 1060                 1065             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Arg Asn 
    1070                 1075                 1080             


Arg Ile  Ala Phe Ala Asn Ile  Asn Pro Phe Ser Leu  Ser Ser Ala 
    1085                 1090                 1095             


Asp Thr  Ser Glu Glu Lys Lys  Leu Asp Ile Ala Asn  Gln Leu Lys 
    1100                 1105                 1110             


Asp Lys  Thr His Lys Ile Ile  Lys Arg Ile Ile Glu  Ile Glu Lys 
    1115                 1120                 1125             


Pro Ile  Glu Thr Lys Glu 
    1130                 


<210>  1806
<211>  1254
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1806

Met Lys Asp Asn Arg Ser Phe Gln Gly Val Arg Thr His Arg Gly Pro 
1               5                   10                  15      


Arg Thr Asn Asn Lys Pro Gln Lys Thr Arg Arg Arg Gln Thr Thr Asp 
            20                  25                  30          


Phe Ser Ile Ser Gln Ser Gly Arg His Val Phe Gly Ala Tyr Phe Asn 
        35                  40                  45              


Met Ala Arg Ala Asn Phe Ile Lys Thr Ile Trp His Ile Leu Pro Gln 
    50                  55                  60                  


Val Gly Ile Arg Gly Asn Tyr Pro Glu Ser Lys Val Ala Lys Met Leu 
65                  70                  75                  80  


Gln Ala Leu Tyr Leu Ile Gln Ser Gly His Ser Asp Gln Leu Ser Ala 
                85                  90                  95      


Glu Gln Arg Leu Trp Lys Asn Asn Leu Val Leu Lys Thr Pro Glu Gln 
            100                 105                 110         


Lys Thr Thr Leu Gln Arg Leu Leu Ile Lys His Phe Pro Ile Leu Val 
        115                 120                 125             


Pro Val Met Ala Asp Val Ala Asp Arg Arg Ala Arg Asn Asn Lys Lys 
    130                 135                 140                 


Lys Ser Thr Val Gln Thr Glu Glu Asp Thr Leu Ser Gln Met Lys Gly 
145                 150                 155                 160 


Val Glu Leu Asn Asp Tyr Leu Arg Ala Leu Ser Thr Ile Ala Thr Thr 
                165                 170                 175     


Leu Asn Glu Cys Arg Asn Phe Tyr Thr His Asn Asp Pro Tyr Asn Thr 
            180                 185                 190         


Pro Glu Glu Leu Thr Lys Gln Tyr Ser His Gln Ala Gln Ile Ala Leu 
        195                 200                 205             


Met Leu Asp Lys Ala Ile Thr Ala Ser Arg Arg Val Leu Lys Asp Arg 
    210                 215                 220                 


Glu Gly Leu Thr Thr Arg Glu Leu Glu Phe Leu Thr Gly Val Asp His 
225                 230                 235                 240 


Met Glu Gln Val Thr Val Arg Asp Glu Asn Asn Lys Val Ile Ile Lys 
                245                 250                 255     


Asn Asn Arg Pro Met Lys Arg Phe Val Glu Tyr Asp Asp Phe Tyr Phe 
            260                 265                 270         


Ser Val Trp Gly Lys Arg Asp Gly Gln Lys Ala Leu Ser Asp Phe Gly 
        275                 280                 285             


Leu Leu Tyr Phe Cys Val Leu Phe Leu Ser Lys Thr Tyr Ala Lys Leu 
    290                 295                 300                 


Leu Ile Glu Glu Ser Arg Leu Phe Glu Phe Ser Pro Phe Thr Asp Glu 
305                 310                 315                 320 


Glu Asn Leu Val Met Gln Glu Met Met Ser Ile Tyr Arg Ile His Thr 
                325                 330                 335     


Pro Lys Leu His Arg Leu Ser Ser Arg Asp Asp Lys Ala Ala Leu Ala 
            340                 345                 350         


Met Asp Met Leu Ser Glu Leu Arg Arg Cys Pro Arg Glu Leu Tyr Asp 
        355                 360                 365             


Leu Leu Ser Asp Glu Asp Lys Gln Val Phe Leu Asp Gly Gly Lys Asp 
    370                 375                 380                 


Glu Lys Gly Glu Glu Thr Glu Leu Ile Lys Gln Leu Arg Tyr Thr Asp 
385                 390                 395                 400 


Arg Phe Pro Gln Leu Ala Leu Arg Phe Ile Asp Glu Thr Glu Leu Phe 
                405                 410                 415     


Lys His Ile Arg Phe Gln Leu Ser Leu Gly Thr Phe Arg Tyr Arg Phe 
            420                 425                 430         


Tyr Asp Lys Val Cys Ile Asp Gly Ile Glu Arg Val Arg Arg Ile Gln 
        435                 440                 445             


Lys Thr Ile Asn Gly Tyr Gly Arg Leu Gln Glu Val Ala Asp Lys Arg 
    450                 455                 460                 


Met Glu Lys Trp Gly Asp Met Leu Gln Lys Lys Glu Glu Arg Glu Val 
465                 470                 475                 480 


Ala Leu Glu Asn Glu Asp Leu Thr Leu Asn Leu Asp Gln Ile Val Ala 
                485                 490                 495     


Asp Thr Ala Asp Thr Leu Pro Tyr Ile Thr Asp Arg Gln Pro Ser Tyr 
            500                 505                 510         


Asn Ile Ser Asn Asn Arg Ile Gly Leu Tyr Trp Glu Ser Ser Arg Asp 
        515                 520                 525             


Lys Arg Glu Tyr Arg Phe Phe Asp Ala Asn Glu Met Tyr Leu Pro Glu 
    530                 535                 540                 


Leu Ser Val Arg Asp Asp Gly Lys Ala Glu Val Ala Met Pro Ala Pro 
545                 550                 555                 560 


Lys Cys Phe Leu Ser Thr Arg Asp Leu Ser Ala Met Leu Phe Tyr Glu 
                565                 570                 575     


His Leu Arg Val Gln His Pro Met Asp Leu Pro Ser Ala Glu Gln Ile 
            580                 585                 590         


Ile Met Asp Tyr Glu Ala Glu Tyr Arg Arg Phe Phe Ala Asp Val Ala 
        595                 600                 605             


Glu Gly Arg Leu His Pro Ala Thr Lys Pro Arg Tyr Phe Arg Asn Tyr 
    610                 615                 620                 


Leu Lys Leu Asn Tyr Pro Leu Leu Ser Leu Ser Asp Ile Pro Asp Lys 
625                 630                 635                 640 


Leu Gln Leu Tyr Leu Ser Gly Lys Gln Leu Ser His Glu Gly Thr Ala 
                645                 650                 655     


Glu Thr Ala Arg Glu Arg Leu Ile Arg Leu Thr Met Asp Ala Leu Asn 
            660                 665                 670         


Lys Arg Glu Glu Gln Thr Lys Arg Arg Leu Glu Arg Tyr Leu Asp Ala 
        675                 680                 685             


Lys Lys Gln Ile Gly Asp Lys Thr Asn Lys Leu Gly Lys Arg Ser Phe 
    690                 695                 700                 


Ala Glu Ile Arg His Gly Val Leu Ala Glu Tyr Ile Ala Gln Ser Met 
705                 710                 715                 720 


Met Glu Trp Gln Pro Ser Lys Asp Gly Ala Gly Lys Asp Lys Leu Thr 
                725                 730                 735     


Gly Lys Asn Tyr Arg Val Leu Val Asp Tyr Leu Ala Thr Tyr Gly Ala 
            740                 745                 750         


Leu Asp Asn Asp Pro Glu Ala Leu Pro Ile Glu Gln Val Met Gln Asn 
        755                 760                 765             


Ala His Leu Leu Gly Gly Ala Asn Pro His Pro Phe Ile Ala Lys Val 
    770                 775                 780                 


Leu Ala Lys Gly Asp Thr Asn Ile Glu Asp Phe Tyr Gln His Tyr Leu 
785                 790                 795                 800 


Glu Ala Glu Leu Gln His Ile Arg Ala Arg Arg Gln Ser Leu Gln Thr 
                805                 810                 815     


Asn Pro Ser Asp Lys Ala Leu Ala Ala Leu Pro Phe Val His His Glu 
            820                 825                 830         


Arg Ala Arg Phe Ala Glu Pro Thr Pro Glu Glu Met Gln Thr Leu Ala 
        835                 840                 845             


Gly Arg Tyr Glu Thr Leu Met Leu Pro Asp Gly Leu Phe Thr Lys Tyr 
    850                 855                 860                 


Ile Val Glu Leu Leu Lys Lys Ala Tyr Ser Asp His Ala Glu Leu Gln 
865                 870                 875                 880 


Glu Ala Leu Asn Asn Asp Ala Glu Pro Lys Leu Asn Pro Leu Arg Asn 
                885                 890                 895     


Ala Ala Tyr Leu Ile Ser Leu Tyr Tyr Arg Thr Val Leu His Asp Gln 
            900                 905                 910         


Ser Gln Pro Tyr Tyr Phe Phe Lys Arg Asn Tyr Asp Leu Phe Pro Thr 
        915                 920                 925             


Leu Ser Asn His Lys Ser Lys Val Phe Pro Phe Glu Leu Leu Pro Met 
    930                 935                 940                 


Tyr Leu Ser Ser Glu Glu Ile Gln Ser Arg Leu Ala Ala Lys Leu Met 
945                 950                 955                 960 


Asp Arg Asn Gly Gln Pro Val Ala Val Met Glu Asn Gly Lys Pro Lys 
                965                 970                 975     


Arg Asp Glu Gln Asn Asn Ile Ile Trp Gln Arg Gln Ile Thr Thr Glu 
            980                 985                 990         


Ile Asp Arg Cys Val Gln Arg Glu  Arg Ala Asp Lys Arg  Glu Ala Val 
        995                 1000                 1005             


Arg Ala  Lys Leu Leu Lys Glu  Val Lys Phe Ile Lys  Asp Asn Glu 
    1010                 1015                 1020             


Arg Thr  Ile Arg Arg Tyr Lys  Asn Gln Asp Met Thr  Leu Phe Leu 
    1025                 1030                 1035             


Ile Ala  Arg Gly Leu Leu Gln  Gln Ile Leu Thr Leu  Asp Ala Gln 
    1040                 1045                 1050             


Thr Val  Glu Gln Ser Gly Met  Arg Leu Glu Asn Val  Phe Glu Asn 
    1055                 1060                 1065             


Thr Phe  Leu Arg Gln Thr Leu  Thr Ile Arg Ile Pro  Val Gln Ala 
    1070                 1075                 1080             


Gly Gly  Lys Thr Ile Tyr Val  Glu Gln Gly Asn Met  Ser Leu Lys 
    1085                 1090                 1095             


Asn Tyr  Gly Glu Phe Tyr Arg  Phe Leu Ser Asp Glu  Arg Leu Pro 
    1100                 1105                 1110             


Ser Leu  Met Asn Asn Ile Ala  Asp Ser Ile Ala Pro  Asn Glu Lys 
    1115                 1120                 1125             


Gly Glu  Tyr Val Ile Arg Phe  Gly Asp Leu Met Gly  Glu Leu Ala 
    1130                 1135                 1140             


Ser Tyr  Asp Arg Lys Arg Ser  Glu Ile Phe Arg Leu  Met Gln Gln 
    1145                 1150                 1155             


Ile Glu  Ala Ile Ala Met Asn  Ser Asp Ala Ala Leu  Gln Asn Pro 
    1160                 1165                 1170             


Asn Asp  Ser Arg Phe Trp Ala  His Glu Gly Leu Pro  Gln Arg Asn 
    1175                 1180                 1185             


Ser Phe  Lys Ala Met Val Ala  Leu Leu Asp Gln Leu  Asn Glu Thr 
    1190                 1195                 1200             


Pro Met  Leu Pro Glu Gln Arg  Thr Leu Leu Val Ala  Ile Arg Asn 
    1205                 1210                 1215             


Ala Phe  Ser His Asn Thr Tyr  Asn Ile Asp Leu Ser  Thr Ile Gln 
    1220                 1225                 1230             


Glu Val  Lys His Leu Pro Glu  Val Ala Ser Gly Ile  Leu Lys His 
    1235                 1240                 1245             


Leu Gln  Leu Leu Ile Asn 
    1250                 


<210>  1807
<211>  1310
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1807

Met Gly Lys Asp Tyr Lys Thr Gln Gln Pro Lys Lys Val Arg Arg Gln 
1               5                   10                  15      


Gln Lys Thr Asn Phe Ser Ile Asn Leu Thr Gly Lys His Val Phe Gly 
            20                  25                  30          


Ala Tyr Phe Asn Met Ala Arg Thr Asn Phe Val Lys Thr Ile Asn Tyr 
        35                  40                  45              


Ile Met Ser Ile Ala Gly Ile Arg Gly Ser Tyr Ser Glu Ser Gln Ile 
    50                  55                  60                  


Asn Lys Met Leu His Ala Leu Phe Leu Ile Gln Ala Gly Arg Ser Gly 
65                  70                  75                  80  


Glu Leu Thr Lys Glu Gln Arg Gln Trp Glu Lys Lys Leu Arg Leu Asn 
                85                  90                  95      


Thr Glu Gln Gln Thr Arg Leu Gln Lys Leu Leu Phe Lys His Phe Pro 
            100                 105                 110         


Val Leu Gly Pro Met Met Ala Asp Val Ala Asp His Lys Ala Phe Leu 
        115                 120                 125             


Asn Lys Lys Lys Ser Lys Val Gln Thr Glu Glu Asp Lys Phe Ala Gln 
    130                 135                 140                 


Leu Lys Gly Val Ser Leu Ala Asp Cys Leu Asp Val Ile Cys Leu Met 
145                 150                 155                 160 


Ala Asp Ala Leu Thr Glu Cys Arg Asn Phe Tyr Thr His Lys Ala Pro 
                165                 170                 175     


Tyr Asn Ala Pro Ser Gln Leu Ala Ala Gln Tyr Gln His Gln Glu Met 
            180                 185                 190         


Ile Ala Lys Lys Leu Asp Lys Val Val Val Ala Cys Arg Arg Val Leu 
        195                 200                 205             


Lys Asp Arg Glu Gly Leu Ser Val Asn Glu Val Glu Phe Leu Thr Gly 
    210                 215                 220                 


Ile Asp His Leu His Gln Glu Val Val Lys Asp Glu Ser Gly Asn Val 
225                 230                 235                 240 


Lys Lys Lys Asn Gly Lys Val Met Lys Thr Phe Val Asp Tyr Asp Asp 
                245                 250                 255     


Phe Tyr Phe Lys Ile Ser Gly Lys Arg Leu Val Lys Gly Phe Thr Val 
            260                 265                 270         


Ala Val Lys Asp Asp Lys Pro Val Asn Ile Asp Thr Met Leu Pro Ala 
        275                 280                 285             


Leu Ser Asp Phe Gly Leu Leu Tyr Phe Cys Val Leu Phe Leu Ser Lys 
    290                 295                 300                 


Pro Tyr Ala Lys Leu Phe Ile Asp Glu Val Arg Leu Phe Glu Phe Ser 
305                 310                 315                 320 


Pro Phe Thr Asp Thr Glu Asn Met Ile Met Ser Glu Met Leu Ser Ile 
                325                 330                 335     


Tyr Arg Ile Arg Thr Pro Arg Leu His Lys Ile Asp Ser Arg Asp Asn 
            340                 345                 350         


Lys Ala Thr Leu Ala Met Asp Ile Phe Gly Glu Leu Arg Arg Cys Pro 
        355                 360                 365             


Ile Glu Leu Tyr Glu Leu Leu Asp Lys Asn Met Gly Gln Pro Phe Phe 
    370                 375                 380                 


His Asp Glu Val Lys His Pro Asn Ser His Thr Pro Glu Val Ser Lys 
385                 390                 395                 400 


Arg Leu Arg Tyr Asn Asp Arg Phe Pro Thr Leu Ala Leu Arg Tyr Ile 
                405                 410                 415     


Asp Glu Thr Glu Leu Phe Lys Arg Ile Arg Phe Gln Leu Gln Leu Gly 
            420                 425                 430         


Ala Phe Arg Tyr Arg Phe Tyr Asp Lys Glu Asp Cys Ile Asp Gly Ile 
        435                 440                 445             


Val Arg Val Arg Arg Ile Gln Lys Asp Ile Asn Gly Tyr Gly Arg Leu 
    450                 455                 460                 


Gln Glu Val Ala Asp Lys Arg Ile Glu Lys Trp Gly Asp Leu Ile Gln 
465                 470                 475                 480 


Lys Arg Glu Glu His Ala Val Lys Leu Glu His Glu Glu Leu Tyr Ile 
                485                 490                 495     


Asp Leu Asp Gln Phe Val Glu Asp Thr Ala Asp Ser Ile Pro Tyr Val 
            500                 505                 510         


Thr Asp Arg Arg Pro Ser Tyr Asn Ile His Ala Asn Arg Ile Gly Leu 
        515                 520                 525             


Tyr Trp Glu Asp Ser Gln Asn Pro Lys Ser Tyr Lys Ile Phe Asp Glu 
    530                 535                 540                 


Asn Gly Met Tyr Ile Pro Glu Leu Val Val Thr Glu Asp Glu Lys Ala 
545                 550                 555                 560 


Pro Ile Lys Met Pro Ala Pro Arg Cys Thr Leu Ser Val Tyr Asp Leu 
                565                 570                 575     


Ser Ala Met Leu Phe Tyr Glu Tyr Leu His Glu His Gln Asp Val Asp 
            580                 585                 590         


Thr Pro Ser Ala Glu Arg Ile Ile Ile Asp Cys Glu Asp Asp Tyr Arg 
        595                 600                 605             


Arg Phe Phe Lys Ala Val Ala Glu Gly Thr Leu Thr Pro Phe Lys Lys 
    610                 615                 620                 


Thr Lys Glu Phe Arg Glu Tyr Leu Glu Arg Glu Tyr Pro Lys Leu Arg 
625                 630                 635                 640 


Met Ala Asp Ile Pro Glu Lys Leu Gln Leu Tyr Leu Thr Ser Lys Gly 
                645                 650                 655     


Leu Thr His Asp Asn Lys Pro Glu Thr Val His Glu Arg Met Ile Arg 
            660                 665                 670         


Leu Thr Arg Glu His Leu Glu Glu Arg Glu Ile His Val Gln Arg Arg 
        675                 680                 685             


Leu Glu His Tyr Gln Glu Asp Arg Lys Met Ile Gly Glu Lys Glu Asn 
    690                 695                 700                 


Lys Tyr Gly Lys Lys Ser Phe Ala Asp Val Arg His Gly Thr Leu Ala 
705                 710                 715                 720 


Arg Tyr Leu Ala Gln Ser Met Met Glu Trp Gln Pro Thr Lys Leu Lys 
                725                 730                 735     


Asp Lys Glu Lys Gly His Asp Lys Leu Thr Gly Leu Asn Tyr Asn Val 
            740                 745                 750         


Leu Thr Ala Tyr Leu Ala Thr Tyr Gly His Pro Gln Val Ser Glu Asp 
        755                 760                 765             


Asp Phe Val Pro Leu Thr Leu Glu Gln Val Leu Thr Asn Ala His Leu 
    770                 775                 780                 


Leu Gly Gly Asn Asn Pro His Pro Phe Ile Gly Lys Val Leu Ala Leu 
785                 790                 795                 800 


Gly Asn Arg Asn Ile Glu Glu Leu Tyr Leu His Tyr Leu Glu Glu Glu 
                805                 810                 815     


Leu Lys His Ile Arg Ser Arg Lys Gln Ser Leu Leu Ser Asn Pro Ser 
            820                 825                 830         


Asp Lys Ala Leu Ser Ala Leu Pro Phe Val His Tyr Asp Arg Val Arg 
        835                 840                 845             


Phe His Glu Arg Thr Asp Glu Glu Met Arg Ala Leu Ala Ala Arg Tyr 
    850                 855                 860                 


Thr Thr Ile Gln Leu Pro Asp Gly Leu Phe Thr Pro Tyr Ile Leu Glu 
865                 870                 875                 880 


Ile Leu Lys Lys His Tyr Thr Glu Asn Thr Glu Leu Gln Asn Ala Leu 
                885                 890                 895     


Arg Gln Asp Ala Pro Ser Lys Ile Asn Pro Thr Asn Asn Ala Ala Tyr 
            900                 905                 910         


Leu Ile Thr Leu Phe Tyr Lys Thr Val Leu Lys Asp Asp Ala Gln Pro 
        915                 920                 925             


Phe Tyr Ile Ser Gly Lys Ala Tyr Thr Arg Asn Lys Asp Gly Glu Lys 
    930                 935                 940                 


Ala Glu Ala Phe Ser Phe Lys Arg Ser Tyr Glu Leu Phe Ser Val Leu 
945                 950                 955                 960 


Asn Asn Asn Lys Lys Lys Thr Phe Pro Tyr Glu Leu Leu Pro Leu Phe 
                965                 970                 975     


Leu Thr Ser Asp Glu Ile Gln Glu Arg Leu Ser Ala Lys Leu Leu Asp 
            980                 985                 990         


Asp Asn Gly Asn Pro Ile Pro Glu  Ala Gly Lys Arg Gly  Lys Pro Ala 
        995                 1000                 1005             


Thr Asp  Ile Gln Gly Asn Thr  Ile Trp Gln Arg Gln  Ile Lys Gln 
    1010                 1015                 1020             


Lys Ile  Asn Gly Tyr Val Asn  Ser Leu Ser Asp Lys  Asp Leu Lys 
    1025                 1030                 1035             


Ile Ser  Met Asn Gln Ser Trp  Lys Lys Lys Glu Glu  Glu Arg Ala 
    1040                 1045                 1050             


Ala Lys  Arg Glu Ala Met Gln  Ser Arg Leu Thr Lys  Gln Ile Asn 
    1055                 1060                 1065             


Glu Val  Lys Gly Asn Glu Arg  Thr Leu Arg Arg Tyr  Lys Thr Gln 
    1070                 1075                 1080             


Asp Met  Val Ser Phe Leu Met  Ala Lys Glu Leu Phe  Ala Thr Ile 
    1085                 1090                 1095             


Ile Ser  Asp Gln Gly Asn Glu  Val Asn Trp Lys Gln  Met Arg Leu 
    1100                 1105                 1110             


Ser Lys  Val Cys Asn Glu Ala  Phe Leu Arg Gln Thr  Leu Thr Phe 
    1115                 1120                 1125             


Arg Val  Pro Val Thr Val Gly  Asn Thr Thr Ile Tyr  Val Glu Gln 
    1130                 1135                 1140             


Glu Asn  Met Ser Leu Lys Asn  Tyr Gly Glu Phe Tyr  Arg Phe Leu 
    1145                 1150                 1155             


Thr Asp  Asp Arg Leu Met Ser  Leu Leu Asn Asn Ile  Val Glu Thr 
    1160                 1165                 1170             


Leu Lys  Pro Asn Glu Asp Gly  Glu Leu Val Ile Arg  His Thr Asp 
    1175                 1180                 1185             


Leu Met  Ser Glu Leu Ala Ala  Tyr Asp Gln Tyr Arg  Ser Thr Ile 
    1190                 1195                 1200             


Phe Lys  Leu Ile Gln Asn Ile  Glu Asp Leu Ile Ile  Lys Glu Asn 
    1205                 1210                 1215             


Ala Ala  Leu Asn Asp Pro Asp  Ala Asp Gly Phe Trp  Val Arg Lys 
    1220                 1225                 1230             


Asp Leu  Pro Lys Arg Asn Asn  Phe Ala Ser Leu Leu  Glu Leu Leu 
    1235                 1240                 1245             


Asn Gln  Leu Asn Asn Val Asp  Leu Thr Asp Asp Glu  Arg Lys Leu 
    1250                 1255                 1260             


Leu Val  Ala Ile Arg Asn Ala  Phe Ser His Asn Ser  Tyr Asn Ile 
    1265                 1270                 1275             


Asp Phe  Ser Leu Ile Arg Asn  Val Lys His Leu Pro  Glu Val Ala 
    1280                 1285                 1290             


Lys Gly  Ile Leu Gln His Leu  Gln Ser Val Leu Gly  Val Glu Ile 
    1295                 1300                 1305             


Thr Lys  
    1310 


<210>  1808
<211>  1120
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1808

Met Lys Thr Lys Val Leu Gly Asn Ser Pro Phe Glu Lys Pro Asn Tyr 
1               5                   10                  15      


Lys Lys Phe Lys Arg Glu Glu Asp Lys Pro Phe Tyr Ala Thr Tyr Leu 
            20                  25                  30          


Asn Thr Ala Lys Gln Asn Val Phe Leu Ile Leu Arg Glu Ile Ser Asp 
        35                  40                  45              


Lys Leu Glu Leu Gly Phe Thr Thr Lys Asp Thr Gly Met Leu Ser Thr 
    50                  55                  60                  


Glu Leu Trp Ser Lys Leu Lys Asn Asn Asp Gln Pro Glu Val Ser Gln 
65                  70                  75                  80  


Lys Ile Ile Glu Arg Leu Glu Asn Gln Phe Thr Phe Leu Arg Gln Leu 
                85                  90                  95      


Ala Leu Asn His Ala Arg Asp Lys Ala Tyr Ser Ser Glu Val Asp Ser 
            100                 105                 110         


Tyr Gln Asn Asp Tyr Asn Gly Asp Ser Gln Asp Lys Ile Asn Ser Asn 
        115                 120                 125             


Glu Ala Glu Ser Ser Pro Glu Asp Tyr His Asp Val Leu Lys Leu Trp 
    130                 135                 140                 


Ile Glu Gln Leu Asn Ser Tyr Arg Asn Tyr Tyr Thr His Ala Lys His 
145                 150                 155                 160 


Lys Pro Val Gln Leu Asp Pro Ala Val Ile Asp Gly Met Arg Asp Leu 
                165                 170                 175     


Phe Asp Ala Asp Trp Lys Glu Phe Lys Asp Arg Phe Gly Phe Glu Asp 
            180                 185                 190         


Ser Val Val Gly His Leu Ile Arg Arg Gly Lys Asn Gly Glu Leu Ala 
        195                 200                 205             


Asn Phe Thr Tyr Ala Phe Ala Asp Arg His Gly Thr Thr Glu Lys Gly 
    210                 215                 220                 


Phe Leu Tyr Phe Val Cys Leu Trp Leu Glu Lys Lys Asp Ala Gln Glu 
225                 230                 235                 240 


Leu Leu Lys Lys His Glu Gly Phe Lys Arg Ser Ser Leu Ser Tyr Glu 
                245                 250                 255     


Lys Ala Thr Leu Glu Arg Tyr Thr Trp Phe Arg Thr Lys Ile Pro Lys 
            260                 265                 270         


Pro Lys Leu Val Ser Asp His Ser Glu Ala Gly Leu Phe Met Asp Met 
        275                 280                 285             


Val Asn Glu Leu Lys Arg Cys Pro Gln Pro Leu Tyr Asn Thr Leu Ser 
    290                 295                 300                 


Glu Lys Asp Lys Asp Thr Phe Lys Gln Leu Asp Thr Ala Asp Ala Ser 
305                 310                 315                 320 


His Gly Gln Glu Ser Glu Gly Asp Glu Asp Tyr Thr Leu Thr Pro Val 
                325                 330                 335     


Leu Lys Arg His Ser Asn Arg Phe Tyr Tyr Phe Ala Leu Arg Tyr Leu 
            340                 345                 350         


Asp Gln Ser Phe Glu His Leu Arg Phe His Val Asp Leu Gly Asn Tyr 
        355                 360                 365             


Cys Phe His Ser Tyr Asp Gln Val Ile Glu Asp Met Pro Arg Lys Arg 
    370                 375                 380                 


Arg Trp Ile Lys Arg Met Thr Gly Phe Gly Lys Leu Thr Asp Phe Asp 
385                 390                 395                 400 


Glu Ala His Arg Pro Ala Thr Trp Gly Glu Lys Leu Pro Asp Pro Leu 
                405                 410                 415     


Ala Gln Glu Lys Pro Asp Thr Tyr Ile Thr Lys Thr Thr Pro His Tyr 
            420                 425                 430         


His Leu Asp Gly Thr Gly Glu Val Lys Asn Ile Gly Ile Lys Trp Val 
        435                 440                 445             


Asp Ser Tyr Asp Arg Lys Lys Ile Trp Pro Asn Val Ser Glu Pro Tyr 
    450                 455                 460                 


Thr His Gly Lys Ser Asp Arg Pro His Thr Glu Ala Pro Asp Phe Trp 
465                 470                 475                 480 


Leu Ser Leu Tyr Glu Leu Pro Ala Val Ala Phe Tyr Gln Met Leu His 
                485                 490                 495     


Leu Gln Asn Lys Asp Arg Val His Gln Ser Ala Glu Thr Val Ile Arg 
            500                 505                 510         


Asp Tyr Gln Gln Asn Leu Lys Asn Phe Leu Thr Ala Val Ala Gln Gly 
        515                 520                 525             


Arg Ile Ser Pro Gly Tyr Thr Leu Glu Thr Leu Ser Ala Glu Leu Asp 
    530                 535                 540                 


Lys Ser Asn Leu Arg Ile Ser Tyr Ile Pro Lys Ala Val Val Lys Tyr 
545                 550                 555                 560 


Leu Leu Asn Lys Lys Gly Lys Ala Tyr Asp Glu Lys Ala Asn Ile Arg 
                565                 570                 575     


Leu Gln Glu Leu Gln Lys Glu Asn Ser Arg Leu Leu Ser Lys Val Asn 
            580                 585                 590         


Arg Gln Lys Pro His Tyr His Lys His Thr Ser Asn Lys Asp Tyr Val 
        595                 600                 605             


Ala Met Lys Ala Gly Tyr Met Ala Asp Phe Leu Ala Arg Asp Met Ile 
    610                 615                 620                 


Arg Leu Gln Gln Pro Ile Asp Gln Asp Gln Gly Lys Ala Asn Gly Thr 
625                 630                 635                 640 


Glu Phe Gln Leu Leu Gln Ala Lys Leu Ala Leu Phe Gly Lys Ser Lys 
                645                 650                 655     


Asp Thr Leu His Val Thr Phe Lys Leu Cys Asn Leu Ile Asp Ala Ala 
            660                 665                 670         


Asn Pro His Pro Phe Leu His Lys Ile Lys Leu Ser Lys Cys His Gly 
        675                 680                 685             


Ile Leu Ala Phe Tyr Thr Glu Tyr Leu His Leu Arg Asp Gly Tyr Leu 
    690                 695                 700                 


Leu Gln Cys Leu Gln Glu Lys Lys Tyr Asn Lys Tyr His Phe Leu Lys 
705                 710                 715                 720 


Leu Asn Pro Val Asp Thr Asn Ile Gln Thr Leu Ile Glu Arg Gln Leu 
                725                 730                 735     


Asp Ala Val Met Asn Leu Pro Arg Gly Leu Phe Lys Gln Pro Ile Leu 
            740                 745                 750         


Gln Ala Met Thr Ile Ile Asn Ala Thr Lys Thr Leu Val Gln Gln Leu 
        755                 760                 765             


Lys Glu Leu Pro Ser Val Asn Val Ala Tyr Met Ile Gln Ser Tyr Phe 
    770                 775                 780                 


Glu His Val Arg His Asp Gly Asn Gln Glu Phe Tyr Thr Tyr Lys Arg 
785                 790                 795                 800 


Asn Tyr Glu Leu Leu Asp Lys Leu Tyr Asp Asn Lys Thr Gly Arg Ser 
                805                 810                 815     


Lys Thr Lys Ala Arg Tyr Phe Thr Gly Gln Glu Leu Glu Gln Lys Thr 
            820                 825                 830         


Lys Glu Ile Lys Gln Lys Leu Ala Gln Lys Ile Asp Ala Ala Ile Arg 
        835                 840                 845             


Lys Lys Ala Asn Ala Thr Glu Glu Glu Lys Gln Arg Ile Arg Asp Asn 
    850                 855                 860                 


Tyr Gln Lys Ala Tyr Lys Ala Phe Thr His Ser Glu Lys Gln Ile Arg 
865                 870                 875                 880 


Leu His Lys Ser Cys Asp Thr Val Leu Phe Met Met Val Asp His Met 
                885                 890                 895     


Tyr Arg Tyr Gly Asp Phe Leu Leu Asp Arg Arg Lys Lys Lys Asn Glu 
            900                 905                 910         


Gln Pro Gln Leu Leu Glu Leu Ala Asp Ser Tyr Lys Leu Arg Ser Ile 
        915                 920                 925             


Lys Pro Asp Thr Asp Gln Ser Phe Leu Ser Met Leu Leu Pro Ile Ala 
    930                 935                 940                 


Ile Pro Val Phe Tyr Pro Glu Lys Thr Ser Lys His Gln Arg Thr Ile 
945                 950                 955                 960 


Ala Arg Glu Gln Leu Lys Val Lys Asn Tyr Gly Asp Phe Arg Ser Phe 
                965                 970                 975     


Leu Lys Asp Arg Arg Leu Tyr Thr Leu Leu Pro Tyr Ile Ser Asp Glu 
            980                 985                 990         


Val Val Gln Phe Glu Ala Ile Gln  Arg Glu Phe Ala Ala  Tyr His Arg 
        995                 1000                 1005             


Ser Arg  Glu Ser Val Phe Glu  Lys Ile Leu Ser Phe  Glu Lys Thr 
    1010                 1015                 1020             


Val Ile  Ala Gln His Asn Ile  Gln Pro Asn Lys Tyr  Gly Tyr Ile 
    1025                 1030                 1035             


Glu His  Lys Asp Ile Leu Asp  Glu Ala Arg Ile Pro  Glu Glu Gln 
    1040                 1045                 1050             


Tyr His  Gln Met Ile Asp Ile  Arg Asn Ala Leu Cys  His Gly Thr 
    1055                 1060                 1065             


Tyr Pro  Asn Pro Glu Lys Phe  Lys Asp Gln Val Asp  Gly Ser Asp 
    1070                 1075                 1080             


Phe Asn  Ala Leu Lys His Ile  Gly Leu Asn Ala Pro  Glu Ala Ser 
    1085                 1090                 1095             


Gln Lys  Ser Ile Ile Thr Gln  Leu Glu Gln Ile Ala  Leu Arg Leu 
    1100                 1105                 1110             


Tyr Glu  Lys Pro Lys Lys Asn  
    1115                 1120 


<210>  1809
<211>  1145
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1809

Met Glu Thr Leu Thr Ile Pro Glu Val Ile Lys Cys Arg Thr Leu Ser 
1               5                   10                  15      


Asp Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Ile Ala Lys Glu Phe Asp Leu Pro Leu 
        35                  40                  45              


Leu Ala Glu Glu Gly His Leu Lys Asn Ser Phe Leu Cys Lys Lys Glu 
    50                  55                  60                  


His Asn Lys Val Asn Trp Asn His Val Tyr Ser Arg Thr Lys Arg Phe 
65                  70                  75                  80  


Leu Ala Val Leu Lys Val Phe Asp Ala Glu Thr Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Lys Thr Ile Asn Trp Glu Gly Lys Asp Phe Ala Ser Met Ser Asp 
            100                 105                 110         


Ile Leu Lys Ile Val Phe Gly Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Thr Ile Arg Lys Thr Ala Val 
    130                 135                 140                 


Ser Ala Glu Met Ala Leu Phe Leu Thr Thr Asn Phe Arg Arg Ala Ile 
145                 150                 155                 160 


Glu Tyr Thr Lys Glu Arg Phe Lys Gly Val Leu Asn Asp Glu Asp Tyr 
                165                 170                 175     


Gln Leu Val Ala Ser Lys Lys Val Leu Glu Ala Asn Ser Thr Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Arg Phe Ile Gly Ile Ile Thr Gly Leu Lys Gly Thr Gln Asn 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro His Asp Arg Phe Gln Ser Asp Asn Pro Arg Gln Ala Phe Ser 
                245                 250                 255     


Leu Asp Leu Ile Asn Glu Leu Asn Arg Cys Pro Lys Val Leu Tyr Asn 
            260                 265                 270         


Ala Ile Thr Glu Glu Gly Lys Gln Lys Leu Arg Ser Ile Pro Gly Glu 
        275                 280                 285             


Leu Glu Asn Lys Asn Leu His Asp Asn Asn Thr Lys Lys Glu Ala Lys 
    290                 295                 300                 


Ile Glu Ala Glu Ala Tyr Glu Leu Tyr Ile Glu Ser Leu Thr Arg Gln 
305                 310                 315                 320 


Ile Arg Tyr Ser Asn Arg Phe Pro Asp Phe Ala Leu Lys Phe Ile Asp 
                325                 330                 335     


Glu Thr Asp Ile Phe Ser Glu Phe Arg Phe Gln Ile Asp Leu Gly Lys 
            340                 345                 350         


Leu Leu Val Asp Glu Tyr Leu Lys Phe Phe Asn Gly Glu His Val Gln 
        355                 360                 365             


Arg Arg Ile Val Glu Asn Ala Lys Ala Phe Gly Lys Leu Ile Asp Phe 
    370                 375                 380                 


Asn Asp Glu Ala Lys Val Met Thr Arg Ile Gly Asn Gly His Phe Ser 
385                 390                 395                 400 


Lys Arg Phe Glu Gln Phe Ala Pro Phe Tyr Asn Thr Glu Asp Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Arg His His Val Thr Ala Lys Leu Gly Pro Asp Ser 
            420                 425                 430         


Lys Gly Glu Pro Glu Lys Lys Leu Leu Gln Pro Leu Pro Glu Ala Phe 
        435                 440                 445             


Leu Ser Leu His Glu Leu Pro Lys Val Ile Leu Leu Asp Tyr Leu Gln 
    450                 455                 460                 


Lys Gly Glu Pro Glu Lys Leu Ile Asn Asp Phe Ile Leu Ile Asn Asn 
465                 470                 475                 480 


Ser Lys Leu Met Asn Met Ser Phe Ile Glu Ala Val Lys Thr Gln Leu 
                485                 490                 495     


Pro Pro Glu Trp Asp Glu Phe Gln Arg Arg Thr Gly Ser Lys Asn Glu 
            500                 505                 510         


Met Pro Tyr Asn Glu Lys Thr Leu Ala Tyr Leu Leu Gln Arg Lys Gln 
        515                 520                 525             


Ile Leu Asn Lys Ile Leu Ala Glu Phe Gln Leu Asn Asp Lys Gln Ile 
    530                 535                 540                 


Pro Gly Arg Ile Leu Asp Tyr Trp Leu Asn Ile Ala Asp Val Glu Glu 
545                 550                 555                 560 


Glu Arg Ala Val Ser Asp Arg Ile Lys Ser Ile Lys Arg Asp Cys Met 
                565                 570                 575     


Ser Arg Leu Arg Ala Leu Gly Lys Phe Lys Ile Asp Arg Asn Arg Asn 
            580                 585                 590         


Lys Ile Pro Lys Ile Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile 
        595                 600                 605             


Val Asp Met Val Val Ser Glu Gly Lys Lys His Lys Ile Thr Ser Phe 
    610                 615                 620                 


Tyr Tyr Glu Lys Met Gln Asp Cys Leu Ser Leu Phe Ala Asp Pro Leu 
625                 630                 635                 640 


Lys Arg Gln Leu Phe Ile His Ile Ile Thr Asn Glu Leu Arg Leu Asn 
                645                 650                 655     


Asp Ser Gly Gly His Pro Phe Leu Phe Lys Leu Asn Met Arg Gln Ile 
            660                 665                 670         


Asn Cys Thr Ser Asp Phe Tyr Glu Ile Tyr Leu Gln Glu Lys Gly His 
        675                 680                 685             


Lys Met Val Pro Glu Lys Asn Leu Lys Thr Gly Lys Val Val Asn Thr 
    690                 695                 700                 


Asp His Ser Trp Met Ala Leu Thr Phe Tyr Lys Leu Glu Phe Asn Asp 
705                 710                 715                 720 


Lys Val Asp Lys Leu Met Thr Val Val Lys Leu Pro Leu Asn Lys Leu 
                725                 730                 735     


Asn Leu Pro Phe Thr Leu Arg Gln Leu Asn Ala Lys Thr Thr Tyr Thr 
            740                 745                 750         


Leu Glu Gln Trp Leu Lys Asn Leu Thr Leu Gly Lys Lys Pro Asp Asp 
        755                 760                 765             


Gly Lys His Pro Val Asn Leu Pro Thr Asn Leu Phe Asp Glu Lys Leu 
    770                 775                 780                 


Ser Asp Leu Leu Arg Gln Asp Leu Asp Asn Asn Lys Ile Ala Tyr Arg 
785                 790                 795                 800 


Pro Tyr Ala Asn Trp Asn Glu Leu Phe Lys Ile Trp Trp Ile Ser Arg 
                805                 810                 815     


Asn Asp Ser Leu Gln Arg Phe Tyr Asn Ala Glu Arg Glu Tyr His Ile 
            820                 825                 830         


Phe Asn Glu Lys Val Asn Phe Tyr Pro Asn Arg Lys Glu Asn Phe Ala 
        835                 840                 845             


Asp Tyr Tyr Gln His Ala Val Lys Val Ala Phe Gln Lys Lys Arg Asn 
    850                 855                 860                 


Glu Arg Ile Ile Glu Gln Arg Ile Asn Lys Tyr Leu Pro Asp Ile Leu 
865                 870                 875                 880 


Phe Glu Gln Val Glu Lys Thr Phe Lys His Thr Ile Ala Glu Thr Glu 
                885                 890                 895     


Lys Glu Ile Arg Ile Leu Gln Glu Glu Asp Arg Ile Met Leu Leu Met 
            900                 905                 910         


Leu Glu Gly Leu Met Glu Asp Gly Asn Lys Gln Gln Leu Lys Leu Ser 
        915                 920                 925             


Glu Ile Lys Thr Leu Gln Asn Ala Thr Ile Asn Ile Arg Gln Leu Val 
    930                 935                 940                 


Pro Gly Lys Leu Ser Phe Asp Asp Ser Gly Glu Ala Ile Lys Asp Ser 
945                 950                 955                 960 


Thr Asn Pro Glu Ile Val Arg Thr Val Ser Val Ser Ile Lys Arg Ile 
                965                 970                 975     


Glu Tyr Asn Leu Leu Pro Lys Tyr Val Ala Asp Gly Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Pro Asp Glu  Glu Ile Gln Met Glu  Arg Leu Lys 
        995                 1000                 1005             


Thr Glu  Phe Asp Thr Tyr Asn  Lys Val Arg Gln Val  Val Leu Asp 
    1010                 1015                 1020             


Leu Ser  Phe Lys Leu Glu Lys  Met Ile Ile Glu Lys  Gly His Lys 
    1025                 1030                 1035             


Asp Arg  Ile Asn Gln Leu Cys  Thr Gly Ala Thr Gly  Glu Leu Leu 
    1040                 1045                 1050             


Thr Gly  Asn Ile Cys His His  Thr Tyr Leu Thr Trp  Leu Lys Asp 
    1055                 1060                 1065             


Lys Glu  Met Ile Asp Asn Glu  Thr Phe Ile Phe Met  Asn Met Val 
    1070                 1075                 1080             


Gln His  Cys Phe Ser His Asn  Gln Tyr Pro Gln Lys  Lys Thr Met 
    1085                 1090                 1095             


Glu Arg  Ile Ile Asn His Trp  Glu Pro Asp Arg Phe  Ala Leu Thr 
    1100                 1105                 1110             


Ile Ala  Ala Thr Tyr Asn Gln  Lys Ile Ala Gly Ile  Leu Glu Asp 
    1115                 1120                 1125             


Ile Gly  Thr Phe Pro Phe Ile  Arg Ser Arg Lys Thr  Met Pro Asp 
    1130                 1135                 1140             


Val Val  
    1145 


<210>  1810
<211>  1133
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1810

Val Lys Met Glu Asp Asp Lys Lys Thr Thr Glu Ser Thr Tyr Thr Leu 
1               5                   10                  15      


Asp Asn Lys His Phe Gly Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Val Tyr Ile Thr Val Asn His Ile Asn Lys Ile Leu Glu Glu Gly Glu 
        35                  40                  45              


Ile Asn Arg Asp Gly Tyr Glu Thr Thr Leu Lys Asn Ser Trp Asp Glu 
    50                  55                  60                  


Ile Lys Asp Ile Asn Lys Lys Asp Arg Leu Ser Lys Leu Ile Ile Lys 
65                  70                  75                  80  


His Phe Ser Phe Leu Glu Ala Ala Thr Tyr Arg Gln Asn Pro Thr Asp 
                85                  90                  95      


Thr Thr Lys Gln Lys Glu Glu Lys Gln Ala Glu Ala Gln Ser Leu Glu 
            100                 105                 110         


Ser Leu Lys Lys Ser Phe Phe Val Phe Ile Tyr Lys Leu Arg Asp Leu 
        115                 120                 125             


Arg Asn His Tyr Ser His Tyr Lys His Ser Lys Ser Leu Glu Arg Pro 
    130                 135                 140                 


Lys Phe Glu Glu Asp Leu Leu Lys Lys Met Tyr Asn Ile Phe Asn Ala 
145                 150                 155                 160 


Ser Ile Arg Leu Val Lys Glu Asp Tyr Lys His Asn Lys Asn Ile Asn 
                165                 170                 175     


Pro Lys Lys Asp Phe Lys His Leu Asn Arg Lys Arg Lys Gly Lys Phe 
            180                 185                 190         


Tyr Tyr Ser Phe Ala Asp Asn Glu Gly Asn Ile Thr Glu Ser Gly Leu 
        195                 200                 205             


Leu Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Val 
    210                 215                 220                 


Gln Lys Lys Leu Glu Gly Phe Lys Cys Ser Asn Glu Ser Tyr Gln Lys 
225                 230                 235                 240 


Met Thr Asn Glu Val Phe Cys Arg Ser Arg Met Leu Leu Pro Lys Leu 
                245                 250                 255     


Arg Leu Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu 
            260                 265                 270         


Asn Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Arg Gly 
        275                 280                 285             


Asp Asp Arg Glu Lys Phe Arg Val Pro Leu Asp Pro Ile Asp Glu Asp 
    290                 295                 300                 


Tyr Asp Ala Glu Gln Glu Pro Phe Lys Asn Thr Leu Val Arg His Gln 
305                 310                 315                 320 


Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Tyr Asn Glu Ile 
                325                 330                 335     


Phe Ser Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser 
            340                 345                 350         


Ile Tyr Lys Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg His Leu Thr 
        355                 360                 365             


His Lys Leu Tyr Gly Phe Glu Arg Ile Gln Glu Phe Asp Lys Gln Asn 
    370                 375                 380                 


Arg Thr Asp Glu Trp Lys Ser Ile Val Lys Asp Leu Asp Thr Tyr Glu 
385                 390                 395                 400 


Thr Ser Asn Glu Arg Tyr Ile Ser Glu Thr Thr Pro His Tyr His Leu 
                405                 410                 415     


Glu Asn Gln Lys Ile Gly Ile Arg Phe Arg Asn Gly Asn Asn Asp Ile 
            420                 425                 430         


Trp Pro Ser Leu Glu Thr Asn Gly Glu Asn Asn Glu Lys Ser Lys Tyr 
        435                 440                 445             


Lys Leu Asp Lys Gln Tyr Gln Ala Glu Ala Phe Leu Ser Val His Glu 
    450                 455                 460                 


Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Lys Thr Glu Asn Thr 
465                 470                 475                 480 


Asp Asn Asp Asn Glu Ile Glu Thr Lys Lys Lys Glu Asn Lys Asn Asp 
                485                 490                 495     


Lys Gln Glu Lys His Lys Ile Glu Glu Ile Ile Glu Asn Lys Ile Lys 
            500                 505                 510         


Asp Ile Tyr Ala Leu Tyr Asp Ala Phe Ala Asn Gly Glu Ile Asn Ser 
        515                 520                 525             


Lys Glu Glu Leu Lys Glu Tyr Leu Lys Gly Lys Asp Ile Glu Ile Val 
    530                 535                 540                 


His Leu Pro Lys Gln Met Ile Ala Ile Leu Glu Ser Lys Pro Lys Asp 
545                 550                 555                 560 


Met Val Glu Glu Ala Glu Arg Lys Gln Arg Lys Met Val Lys Asp Thr 
                565                 570                 575     


Lys Lys Leu Leu Ala Ala Leu Glu Lys Gln Thr Gln Glu Glu Ile Glu 
            580                 585                 590         


Asp Gly Gly Arg Asn Ile Arg Leu Leu Lys Ser Gly Glu Ile Ala Arg 
        595                 600                 605             


Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln Lys Asp Asn 
    610                 615                 620                 


Glu Gly Asn Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln 
625                 630                 635                 640 


Met Leu Gln Arg Ser Leu Ala Leu Tyr Asn Lys Glu Glu Lys Pro Thr 
                645                 650                 655     


Arg Tyr Phe Arg Gln Val Asn Leu Ile Asn Ser Ser Asn Pro His Pro 
            660                 665                 670         


Phe Leu Lys Trp Thr Lys Trp Glu Glu Cys Asn Asn Ile Leu Ser Phe 
        675                 680                 685             


Tyr Arg Ser Tyr Leu Thr Lys Lys Ile Glu Phe Leu Asn Lys Leu Lys 
    690                 695                 700                 


Pro Glu Asp Trp Glu Lys Asn Gln Tyr Phe Leu Lys Leu Lys Glu Pro 
705                 710                 715                 720 


Lys Thr Asn Arg Glu Thr Leu Val Gln Gly Trp Lys Asn Gly Phe Asn 
                725                 730                 735     


Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg Glu Trp Phe Lys Arg 
            740                 745                 750         


His Gln Asn Asn Ser Glu Glu Tyr Glu Lys Val Glu Ala Leu Asp Arg 
        755                 760                 765             


Val Gly Leu Val Thr Lys Val Ile Pro Leu Phe Phe Lys Glu Glu Tyr 
    770                 775                 780                 


Phe Lys Glu Asp Ala Gln Lys Glu Ile Asn Asn Cys Val Gln Pro Phe 
785                 790                 795                 800 


Tyr Ser Phe Pro Tyr Asn Val Gly Asn Ile His Lys Pro Lys Glu Glu 
                805                 810                 815     


Asp Phe Leu His Arg Glu Glu Arg Ile Glu Leu Trp Asp Lys Lys Lys 
            820                 825                 830         


Asp Lys Phe Lys Gly Tyr Lys Ala Lys Lys Lys Phe Lys Glu Met Thr 
        835                 840                 845             


Asp Lys Glu Lys Glu Glu His Arg Ser Tyr Leu Glu Phe Gln Ser Trp 
    850                 855                 860                 


Asn Lys Phe Glu Arg Glu Leu Arg Leu Val Arg Asn Gln Asp Ile Val 
865                 870                 875                 880 


Thr Trp Leu Leu Cys Thr Glu Leu Ile Asp Lys Leu Lys Val Glu Gly 
                885                 890                 895     


Leu Asn Val Glu Glu Leu Lys Lys Leu Arg Leu Lys Asp Ile Asp Thr 
            900                 905                 910         


Asp Thr Ala Lys Gln Glu Lys Asn Asn Ile Leu Asn Arg Val Met Pro 
        915                 920                 925             


Met Gln Leu Pro Val Thr Val Tyr Glu Ile Asp Asp Ser His Asn Ile 
    930                 935                 940                 


Val Lys Asp Arg Pro Leu His Thr Val Tyr Ile Glu Glu Thr Lys Thr 
945                 950                 955                 960 


Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys Asp Arg Arg 
                965                 970                 975     


Leu Asn Gly Leu Phe Ser Phe Val Lys Thr Pro Ser Glu Ala Glu Ser 
            980                 985                 990         


Glu Ser Asn Pro Ile Ser Lys Ser  Arg Val Glu Ser Glu  Leu Gly Lys 
        995                 1000                 1005             


Tyr Gln  Asn Ala Arg Leu Asn  Ile Ile Glu Asp Met  Leu Ala Leu 
    1010                 1015                 1020             


Glu Lys  Thr Leu Ile Asp Asn  Tyr Asn Ser Leu Asp  Thr Asp Asn 
    1025                 1030                 1035             


Phe His  Asn Met Leu Thr Gly  Trp Leu Lys Leu Lys  Gly Lys Ala 
    1040                 1045                 1050             


Asn Lys  Ala Arg Phe Gln Asn  Glu Val Asp Leu Leu  Val Ala Val 
    1055                 1060                 1065             


Arg Asn  Ala Phe Ser His Asn  Gln Tyr Pro Met Tyr  Asn Glu Asn 
    1070                 1075                 1080             


Leu Phe  Gly Asn Ile Glu Arg  Phe Ser Leu Ser Ser  Ser Asn Ile 
    1085                 1090                 1095             


Ile Glu  Ser Lys Gly Leu Asp  Ile Ala Val Lys Leu  Lys Glu Glu 
    1100                 1105                 1110             


Val Ser  Lys Ala Val Glu Lys  Ile Gln Asn Glu Glu  Asp Asp Lys 
    1115                 1120                 1125             


Lys Glu  Lys Glu Thr 
    1130             


<210>  1811
<211>  1085
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1811

Met Lys Lys Glu Leu Asn Arg Glu Asp Val Phe Thr Gly Gly Lys Thr 
1               5                   10                  15      


Pro Glu Leu Thr Ile Tyr Tyr Asn Ile Ala Tyr Phe Arg Met Ala Gly 
            20                  25                  30          


Leu Ile Asn Ala Leu Cys Gly Asn Lys Leu Glu Arg Asp Lys Asp Ala 
        35                  40                  45              


Leu Glu Gln Phe Met Lys Ala Phe Ile Asn Gly Lys Gln Lys Leu Thr 
    50                  55                  60                  


Asp Met Gln Phe Val Lys Leu Cys Asp Tyr Leu Trp Lys Gly Tyr Lys 
65                  70                  75                  80  


Tyr Asp Lys Asn Arg Ser Glu Tyr Ser Leu Thr Glu Asn Asp Lys Thr 
                85                  90                  95      


Met Val Leu Lys Met Val Ala Lys Leu Gln Asp Ile Arg Asn Phe Gln 
            100                 105                 110         


Ser His Ile Trp His Asp Asn Lys Val Leu Val Phe Asp Ala Asp Leu 
        115                 120                 125             


Val Gln Phe Ile Lys Asn Lys His Leu Glu Ala Ile Asp Ala Gln Arg 
    130                 135                 140                 


Gln Arg Phe Ser Lys Glu Thr Glu Val Tyr Glu Lys Glu Asn Arg Glu 
145                 150                 155                 160 


Leu Lys Lys Lys Lys Asn Lys Glu Leu Leu Phe Asp Ile His Asp Gly 
                165                 170                 175     


Leu Gly Tyr Ile Thr Gly Glu Gly Arg Asn Phe Phe Leu Ser Phe Phe 
            180                 185                 190         


Leu Thr Arg Gly Glu Met Thr Arg Phe Leu Lys Gln Arg Lys Gly Cys 
        195                 200                 205             


Lys Arg Asp Asp Thr Pro Glu Tyr Lys Ile Lys His Leu Val Tyr Arg 
    210                 215                 220                 


His Phe Thr His Arg Asp Gly Ala Thr Arg Thr His Tyr Gly Tyr Glu 
225                 230                 235                 240 


Asp Asn Met Leu Asp Gln Leu Pro Asp Lys Gln Glu Phe Leu Thr Thr 
                245                 250                 255     


Arg His Thr Tyr Arg Leu Ile Asn Tyr Leu Asn Asp Ile Pro Glu Glu 
            260                 265                 270         


Val Thr Asn Pro Glu Leu Phe Pro Leu Phe Asn Thr Ile Ser Asn Gly 
        275                 280                 285             


Ile Leu Ile Lys Glu Ser Val Gly Thr Tyr Ile Ala Phe Ile Asn Lys 
    290                 295                 300                 


Met Pro Leu Leu Ser Asp Phe Glu Phe Ser Glu Val Trp Gly Lys Asp 
305                 310                 315                 320 


Gly Lys Pro Tyr Thr Asn Leu Val Glu Phe Tyr His Lys Thr Gln Pro 
                325                 330                 335     


Gly Phe Lys Phe Arg Thr Asp Leu Asn Ser Phe His Lys Ile Ile Leu 
            340                 345                 350         


Asn Leu Ile Arg Asp Glu Asn Tyr Thr Gly Phe Phe Thr Thr Gln Leu 
        355                 360                 365             


Asn Leu Phe Met Ala His Arg Glu Glu Leu Ile Leu Val Ile Ser Lys 
    370                 375                 380                 


Pro Leu Ile Thr Pro Asn Asp Leu Leu Leu Ile Glu Glu His Tyr Arg 
385                 390                 395                 400 


Tyr Lys Leu Lys Ala Asn Asp Phe Val Arg Glu Lys Leu Gly Glu Trp 
                405                 410                 415     


Lys Glu Lys Ile Glu Lys Gly Lys Trp Glu Lys Ala Asn Glu Gln Lys 
            420                 425                 430         


Asp Lys Leu Ile Asn Leu Leu Gly Gly Val Ile Glu Ile Thr Phe Tyr 
        435                 440                 445             


Asp Phe Tyr Trp Gln Lys Asp Glu Lys Pro Arg Asn Glu Asn Arg Phe 
    450                 455                 460                 


Met Glu Phe Ala Ile Arg Phe Met Ala Asp Phe Asn Leu Leu Pro Asp 
465                 470                 475                 480 


Cys Glu Trp Glu Val Glu Pro Leu Gln Ile Glu Asn Asp Leu Ile Ala 
                485                 490                 495     


Asn Arg Thr Ala Thr Pro Asp Leu Lys Lys Ser Gly Ser Gln Phe Met 
            500                 505                 510         


Asn Gln Leu Thr Asp Asn Tyr Arg Leu Lys Phe Asn Asp Gly Gln Ile 
        515                 520                 525             


Ala Phe Arg Tyr Gln Asn Gln Val Phe Ile Met Gly His Lys Ala Val 
    530                 535                 540                 


Lys Asn Leu Leu Ile Ala Cys Phe Asp Gly Lys Glu Lys Met Leu Asn 
545                 550                 555                 560 


Gly Phe Met Pro Ala Leu Leu Ala Asp Leu Lys Lys Ile Thr Asn Glu 
                565                 570                 575     


His Ile Leu Lys Asn His Gln Ala Leu Asn Thr Leu Ser Leu Leu Asn 
            580                 585                 590         


Asn Asp Ser Ile Pro Ser Tyr Ile Ser Arg Gln Trp Gly Glu Ala Glu 
        595                 600                 605             


Pro Ile Thr Asp Met Lys Lys Lys Ala Ile Ala Arg Met Asp Tyr Ile 
    610                 615                 620                 


Thr Gln Gln Phe Glu Ala Leu Ile Glu Asn His His Tyr Leu Asn Arg 
625                 630                 635                 640 


Ala Asp Lys Asn Arg Gln Ile Met Arg Cys Tyr Lys Phe Phe Glu Trp 
                645                 650                 655     


Gln Tyr Pro Gln Asn Ser Gln Phe Lys Phe Leu Arg Arg Asn Glu Tyr 
            660                 665                 670         


His Arg Met Ser Ile Tyr His Tyr Cys Leu Asp Lys Glu Gln His Lys 
        675                 680                 685             


Tyr Asp Lys Lys Gly His Asn Tyr Leu Tyr Asn Arg Leu Ile Lys Glu 
    690                 695                 700                 


Ser His Asn Glu Ser Gly Asn Ile Glu Gln His Leu Pro Tyr Gln Ile 
705                 710                 715                 720 


Arg Thr Met Leu Asn Asp Ala Lys Asp Phe Asn Asp Tyr Phe Leu Arg 
                725                 730                 735     


Ile Leu Asn Ala Thr His Lys Ile Leu Thr Asp Trp Lys Asn Gln Leu 
            740                 745                 750         


Lys Gln Gly Arg Glu Pro Asn Asn Tyr Tyr Leu Ser Arg Leu Gly Phe 
        755                 760                 765             


Thr Gly Gly Leu Thr Gln Lys Val Val His Thr Arg Leu Leu Pro Phe 
    770                 775                 780                 


Ser Ile His Pro Gly Ile Pro Val Ser Phe Phe Tyr Arg Thr Glu Met 
785                 790                 795                 800 


Asn Gln Asn Pro Ser Phe Asn Leu Ser Ala Lys Val Trp Asn Ser Glu 
                805                 810                 815     


Ser Pro Phe Arg Val Gly Leu Lys Glu Ser Asn Tyr Gln Tyr Ala Lys 
            820                 825                 830         


Tyr Leu Gly Leu Phe Asn Glu Ile Lys Thr Gln Arg Lys Ile Ile Gly 
        835                 840                 845             


Lys Met Asn Gln Leu Ile Ala Glu Asp Ala Leu Leu Trp Gln Ile Ala 
    850                 855                 860                 


Lys Lys Tyr Leu Asp Lys Cys His Pro Lys Phe Ser Glu Ile Ile Asn 
865                 870                 875                 880 


Gln Gln Val Asn Gly Lys Gln Pro Leu Asn Val Lys Ala Ile His Asp 
                885                 890                 895     


Thr Glu Leu Thr Ile Asp Phe Pro Val Asp Lys Asn Leu Tyr Gln Val 
            900                 905                 910         


Val Val Lys Met Lys Gln Leu Asp Asp Phe Met Phe Ile Asp Ser Lys 
        915                 920                 925             


Pro Val Leu Glu Lys Thr Ile Arg Tyr Met Ile Lys Asn Ser Leu Arg 
    930                 935                 940                 


Asp Lys Glu Tyr Gln Gln Arg Val Phe Ile Glu Thr Asn Pro Gly Val 
945                 950                 955                 960 


Phe Lys Ile Pro Tyr Asn Glu Val Val Glu Ala Met Arg Thr Ile Asn 
                965                 970                 975     


His Gln Ala Leu Thr Trp Ala Arg Leu Leu Leu Asp Trp Glu Ser Lys 
            980                 985                 990         


Thr Val Lys Thr Ile Pro Glu Ala  Asp Lys Lys Ala Lys  Leu Gln Glu 
        995                 1000                 1005             


Ala Tyr  Asn Lys Arg Gln Pro  Ala Phe Phe Asn Phe  Asn Asp Ile 
    1010                 1015                 1020             


Cys Arg  Tyr Ala Asp Asp Gly  Lys Gln Leu Lys Asp  Leu Arg Asn 
    1025                 1030                 1035             


Lys Thr  Phe His Thr Glu Val  Pro Glu Thr Trp Thr  Tyr Asp Glu 
    1040                 1045                 1050             


Met Arg  Glu Asn Lys Thr Ile  Lys Met Val Leu Gly  Ile Asn Glu 
    1055                 1060                 1065             


Thr Thr  Phe Leu Lys Lys Asp  Tyr Ala Ile Glu Asn  Ala Arg Thr 
    1070                 1075                 1080             


Ile Glu  
    1085 


<210>  1812
<211>  1402
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1812

Met Ala Asn Phe Val Ser Pro Ser Ser Asp Lys His Ile Phe Gly Thr 
1               5                   10                  15      


Tyr Leu Asn Ile Ala His Thr Asn Phe Tyr Arg Thr Ile Leu His Val 
            20                  25                  30          


Phe Ser Ser Ser Gly Ile Asp Cys Tyr Thr Leu Met Gly Asp Leu Phe 
        35                  40                  45              


Val Thr Glu Lys Thr Val Asp Lys Val Ile Asp Ala Phe Trp His Ile 
    50                  55                  60                  


Ala Lys Gln Glu Asn Ile Glu Glu Ala Leu Asp Ser Leu Leu Asp Ile 
65                  70                  75                  80  


Val Lys Lys Cys Tyr Asp Asp Arg Trp Lys Lys Glu Ser Pro Thr Leu 
                85                  90                  95      


Thr Gly Leu Asn Asp His Glu Lys Lys Asn Lys Glu Gly Glu Phe Lys 
            100                 105                 110         


Ala Pro Leu Thr Asp Glu Gly Pro Thr Gly Glu Lys Ala His Leu Met 
        115                 120                 125             


Ala Ala Phe Thr Leu Arg Ser Glu Gln Glu Glu Arg Leu Arg Lys Leu 
    130                 135                 140                 


Leu Phe Arg His Ile Pro Phe Leu Ala Pro Val Met Ala Asp Met Val 
145                 150                 155                 160 


Ala Asp Glu Phe Arg Lys Lys Gln Lys Asn Glu His Asn Glu Asn Asn 
                165                 170                 175     


Ser Ile Met His Asp Ser Ser Leu Thr Asp Cys Leu Gln Ala Leu Ser 
            180                 185                 190         


His Ile Ala Gln Cys Leu Thr Tyr Ser Arg Asn Phe Tyr Thr His Ala 
        195                 200                 205             


Asn Pro Tyr Asn Thr Glu Ala Asp Gln Glu Lys Gln Tyr Asp Ile Gln 
    210                 215                 220                 


Lys Ile Val Ala Gly Tyr Leu Asp Lys Ala Phe Val Ala Ser Arg Arg 
225                 230                 235                 240 


Ile Ala Lys Lys Arg Asn Gly Tyr Ser Glu Gln Asp Leu Lys Phe Leu 
                245                 250                 255     


Thr Asp Lys Val Ser Ala Asn Gly Ser Pro Glu Glu Phe Arg Met Glu 
            260                 265                 270         


Glu Val Phe Val Leu Asp Glu Asn Gly Gln Lys Ile Lys Lys Val Glu 
        275                 280                 285             


Lys Asp Asp Lys Gly Asn Ile Lys Leu Asp Lys Asp Gly Val Pro Ile 
    290                 295                 300                 


Tyr Ile Tyr Lys Lys Lys Val Ile Lys Asp Glu Asn Gly Lys Pro Ile 
305                 310                 315                 320 


Leu Asn Asn Lys Arg Lys Lys Gln Tyr Glu Ile Ile Tyr Glu Asn Gly 
                325                 330                 335     


Ile Pro Val His Glu Tyr Glu Thr Lys Phe Val Glu Arg Lys Asp Trp 
            340                 345                 350         


Tyr Phe Arg Leu Phe Gly Asn Arg Gln Ile Leu Leu Pro Asp Pro Asn 
        355                 360                 365             


Pro Asp Leu Ser Thr Asn Ser Lys Leu Gly Leu Ser Asp Phe Gly Ile 
    370                 375                 380                 


Leu Tyr Phe Cys Ala Leu Phe Leu Ser Lys Glu Gln Leu Ala Gln Phe 
385                 390                 395                 400 


Cys Thr Glu Thr Arg Val Phe Val Asn Ser Pro Phe Gln Asn Asp Asn 
                405                 410                 415     


Asn Lys Lys Asn Asn Ile Ile Leu Asn Met Met Tyr Val Tyr Gln Thr 
            420                 425                 430         


His Ile Pro Arg Gly Lys Arg Leu Asp Ser Glu Arg Asp Ser Gln Ala 
        435                 440                 445             


Leu Ala Met Asp Met Leu Asn Glu Leu Arg Arg Cys Pro Ile Glu Leu 
    450                 455                 460                 


Tyr Asn Val Leu Pro Glu Ile Gly Lys Arg Glu Phe Glu Asp Asn Val 
465                 470                 475                 480 


Gly His Glu Asn Asn Arg Thr Pro Glu Leu Ser Lys Arg Ile Arg Thr 
                485                 490                 495     


Lys Asp Arg Phe Pro His Leu Ala Leu Arg Tyr Ile Asp Ser Gln Lys 
            500                 505                 510         


Thr Phe Glu Lys Ile Arg Phe Gln Val Arg Leu Gly Ser Tyr Arg Phe 
        515                 520                 525             


Cys Phe Tyr Asp Lys Asn Cys Ile Asp Gly Lys Ser His Pro Arg Gln 
    530                 535                 540                 


Leu His Lys Glu Ile Asn Gly Phe Gly Arg Trp Gln Asp Met Glu Lys 
545                 550                 555                 560 


Glu Arg Lys Glu Gln Tyr Gly Pro Leu Phe Gln Lys Thr Arg Asp Val 
                565                 570                 575     


Ser Val Trp Gln Lys Asp Glu Asn Ala Tyr Val Asn Leu Arg Gln Leu 
            580                 585                 590         


Glu Pro Ile Lys Ala Gly Asp Pro Pro His Ile Thr Asp Thr Ile Thr 
        595                 600                 605             


Gln Tyr Asn Ile His Lys Asn Arg Ile Gly Leu Tyr Trp Asn Thr Asp 
    610                 615                 620                 


Glu Glu Thr Tyr Leu Lys Asp Lys Val Gly Glu Asn Gly Glu Thr Ile 
625                 630                 635                 640 


Tyr Lys Gly Tyr Tyr Leu Pro Glu Leu Lys Ala Glu Glu Arg Pro Asn 
                645                 650                 655     


Asp Lys Arg Lys Arg Arg Lys Ala Pro Leu Asp Met Pro Ala Pro Leu 
            660                 665                 670         


Cys Ser Leu Ser Val Tyr Asp Leu Pro Ala Met Leu Phe Tyr Glu His 
        675                 680                 685             


Leu Arg Lys Glu Glu Gln Leu Thr Ala Glu Glu Phe Pro Ser Ile Glu 
    690                 695                 700                 


Asp Ile Ile Ile Lys Gln Tyr Asp Asn Leu Val Arg Phe Phe Lys Gln 
705                 710                 715                 720 


Val Lys Asp Ile Gln Pro Thr Ser Asp Glu Ser Gln Leu Ala Thr Ile 
                725                 730                 735     


Leu Ser Thr Tyr Gly Leu Asn Lys Gln Ser Val Pro Gln Lys Ile Tyr 
            740                 745                 750         


Asp Tyr Leu Ser Met Lys Lys Thr Val Ile Gly Lys Asp Phe Ser Lys 
        755                 760                 765             


Ser Ala Gly Ile Glu Leu Asn Arg Arg Leu Arg Lys Ala Lys Gly Lys 
    770                 775                 780                 


Leu Lys Glu Phe Leu Ala Asp Lys Glu Lys Ile Glu Ser Gly Asn Asn 
785                 790                 795                 800 


Gln Tyr Gly Lys Asp Ser Phe Ala Ser Ile Arg Tyr Val Gln Leu Ala 
                805                 810                 815     


Asn Tyr Leu Ala Glu Ser Ile Met Asp Trp Met Thr Ala Glu Glu Gly 
            820                 825                 830         


Gly Lys Tyr Lys Leu Thr Gly Leu Asn Tyr Arg Val Leu Ala Ser Ser 
        835                 840                 845             


Leu Ala Thr Phe Gly Thr Arg Gln Thr Asp Glu Asp Ile Leu Gln Met 
    850                 855                 860                 


Leu Ala Asp Ala His Ile Tyr Glu Asp Glu Lys Thr Asp His Pro Phe 
865                 870                 875                 880 


Ile Ala Tyr Thr Leu Gly Asp Asp Asp Asn Pro Val Ile Asp Leu Glu 
                885                 890                 895     


Thr Phe Tyr Glu Asn Tyr Leu Asn Arg Glu Ile Lys Gln Ile Glu Lys 
            900                 905                 910         


Tyr Ile Ser Val Thr Ile Asp Ser Gln Thr Asn Lys Glu Val Ile Thr 
        915                 920                 925             


Leu Lys Lys Thr Pro Asp Asn Leu Pro Phe Leu His Arg Gln Arg Lys 
    930                 935                 940                 


Arg Trp Gln Glu Ser Thr Ile Ala Glu Gln Ala Glu Arg Tyr Leu Tyr 
945                 950                 955                 960 


Ile Ala Glu Glu Gly Lys Lys Glu Leu Asn Arg Thr Thr Leu Leu Leu 
                965                 970                 975     


Pro Asp Gly Leu Phe Thr Pro Tyr Ile Ile Lys Val Phe Lys Gln Asn 
            980                 985                 990         


His Pro Asp Leu Ile Cys Gln Met  Gln Ser Leu Ser Asp  Thr Gln Lys 
        995                 1000                 1005             


Lys Gly  Ile Ala Asn Asn Ala  Ala Tyr Leu Ile Asn  Leu Tyr Phe 
    1010                 1015                 1020             


Glu Ser  Lys Gly Glu Lys Ser  Gln Pro Phe Tyr Asp  Ser Thr Glu 
    1025                 1030                 1035             


Pro Phe  Asp Met Asp Met Asp  Asn Arg Ala Lys Thr  Pro Tyr Lys 
    1040                 1045                 1050             


Tyr Ala  Arg Leu Tyr Asp Tyr  Phe Thr Leu Ile Asp  Asp Glu Gln 
    1055                 1060                 1065             


Lys Lys  Arg Tyr Leu Pro Asn  Thr Ile Ile Leu Ser  Lys Ser Lys 
    1070                 1075                 1080             


Asn Arg  Asn Ser Asp Ile Ala  Val Tyr Ile Arg Lys  Ile Lys Glu 
    1085                 1090                 1095             


Lys Gly  Glu Glu Asp Asn Arg  Gln Thr Tyr Arg Lys  Phe Lys Lys 
    1100                 1105                 1110             


Asp Asn  Pro Asp Lys Lys Asp  Glu Trp Asn Lys Glu  Lys Glu Arg 
    1115                 1120                 1125             


Leu Lys  Asn Glu Leu Lys Gln  Lys Val Glu Arg Ala  Gln Lys Lys 
    1130                 1135                 1140             


Ala Lys  Lys Leu Tyr Cys Asp  Met Glu Asp Asn Glu  Arg Ala Ile 
    1145                 1150                 1155             


Arg Arg  His Lys Thr Gln Asp  Arg Ile Leu Phe Leu  Met Ala Lys 
    1160                 1165                 1170             


Asn Ile  Met Gly Asp Thr Val  Asn Gln Asn Gly Asp  Leu Phe Lys 
    1175                 1180                 1185             


Leu Glu  Asn Val Cys Lys Glu  Glu Phe Leu Ser Gln  Lys Val Gln 
    1190                 1195                 1200             


Val Arg  His Ile Val Thr Ser  Gly Asp Arg Gln Ile  Val Ile Gln 
    1205                 1210                 1215             


Lys Asp  Glu Met Pro Ile Lys  Asp Tyr Gly Lys Ile  Tyr Arg Leu 
    1220                 1225                 1230             


Leu Gly  Asp Glu Arg Thr Val  Val Leu Leu Ser Tyr  Met Leu Phe 
    1235                 1240                 1245             


Ala Asn  Asn Gly Ile Ile Asp  Tyr Asp Asn Leu Thr  Glu Glu Leu 
    1250                 1255                 1260             


Lys Gln  Tyr Asp Thr Gln Arg  Ser Ser Ala Ile Lys  Ser Ala Gln 
    1265                 1270                 1275             


Thr Leu  Glu Asn Lys Arg Phe  Val Gln Ala Lys Glu  Val Leu Thr 
    1280                 1285                 1290             


Asp Pro  Glu Lys Asn Glu Phe  Tyr Gln Gly Asn Arg  Arg Tyr Lys 
    1295                 1300                 1305             


Asn Arg  Ala Cys Thr Lys Glu  Asn Asp Ala Lys Arg  Asn Asn Phe 
    1310                 1315                 1320             


Ser Ser  Leu Leu Lys Asp Leu  Gln Lys Leu Thr Pro  Glu Gln Met 
    1325                 1330                 1335             


Glu Met  Phe Cys Asp Glu Asp  Arg Lys Leu Ile Ile  Ala Ile Arg 
    1340                 1345                 1350             


Asn Ala  Phe Ser His Asn Ser  Tyr Pro Ala Trp Glu  Val Ile Gln 
    1355                 1360                 1365             


Lys Leu  Leu Asp Gln Asn Gln  Asp Val Gln Leu Glu  Leu Lys Gln 
    1370                 1375                 1380             


Ile Ala  Gly Phe Leu Ile Asp  Lys Leu Ser Ser Phe  Val Ala Arg 
    1385                 1390                 1395             


Thr Met  Asn Val 
    1400         


<210>  1813
<211>  1128
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1813

Val Lys Met Glu Asp Asp Lys Lys Thr Thr Glu Ser Thr Tyr Thr Leu 
1               5                   10                  15      


Asp Asn Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Val Tyr Ile Thr Val Asn His Ile Asn Lys Ile Leu Glu Glu Gly Glu 
        35                  40                  45              


Ile Asn Arg Asp Gly Tyr Glu Thr Thr Leu Lys Asn Ser Trp Asn Glu 
    50                  55                  60                  


Ile Lys Asp Ile Asn Lys Lys Asp Arg Leu Ser Lys Leu Ile Ile Lys 
65                  70                  75                  80  


His Phe Pro Phe Leu Glu Ala Ala Thr Tyr Arg Arg Asn Pro Thr Asp 
                85                  90                  95      


Thr Thr Lys Gln Lys Glu Glu Lys Gln Ala Glu Ala Gln Ser Leu Glu 
            100                 105                 110         


Ser Leu Lys Lys Ser Phe Phe Val Phe Ile Tyr Lys Leu Arg Asp Leu 
        115                 120                 125             


Arg Asn His Tyr Ser His Tyr Lys His Ser Lys Ser Leu Glu Arg Pro 
    130                 135                 140                 


Lys Phe Glu Glu Gly Leu Gln Lys Lys Met Tyr Asn Ile Phe Asn Ala 
145                 150                 155                 160 


Ser Ile Arg Leu Val Lys Glu Asp Tyr Gln Tyr Asn Lys Asn Ile Asn 
                165                 170                 175     


Pro Lys Lys Asp Phe Lys His Leu Asn Arg Lys Arg Lys Gly Lys Phe 
            180                 185                 190         


Tyr Tyr Ser Phe Ala Asp Asn Glu Gly Asn Ile Thr Glu Ser Gly Leu 
        195                 200                 205             


Leu Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Val 
    210                 215                 220                 


Gln Lys Lys Leu Glu Gly Phe Lys Cys Ser Asn Glu Ser Tyr Gln Lys 
225                 230                 235                 240 


Met Thr Asn Glu Val Phe Cys Arg Ser Arg Met Leu Leu Pro Lys Leu 
                245                 250                 255     


Arg Leu Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu 
            260                 265                 270         


Asn Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Gln Gly 
        275                 280                 285             


Asp Asp Arg Glu Lys Phe Arg Val Pro Phe Asp Pro Val Asp Glu Asp 
    290                 295                 300                 


Tyr Asp Ala Glu Gln Glu Pro Phe Lys Asn Thr Leu Val Arg His Gln 
305                 310                 315                 320 


Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Tyr Asn Glu Ile 
                325                 330                 335     


Phe Ser Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser 
            340                 345                 350         


Ile Tyr Lys Lys Gln Ile Gly Gly Gln Lys Glu Asp Arg His Leu Thr 
        355                 360                 365             


His Lys Leu Tyr Gly Phe Glu Arg Ile Gln Glu Phe Ala Lys Gln Asn 
    370                 375                 380                 


Arg Pro Asp Glu Trp Lys Ala Ile Val Lys Asp Ser Asp Thr Phe Lys 
385                 390                 395                 400 


Lys Lys Glu Glu Lys Glu Glu Glu Lys Pro Tyr Ile Ser Glu Thr Thr 
                405                 410                 415     


Pro His Tyr His Leu Glu Asn Lys Lys Ile Gly Ile Ala Phe Lys Asn 
            420                 425                 430         


His Asn Ile Trp Pro Ser Thr Gln Thr Glu Leu Thr Asn Asn Lys Arg 
        435                 440                 445             


Lys Lys Tyr Asn Leu Gly Thr Ser Ile Lys Ala Glu Ala Phe Leu Ser 
    450                 455                 460                 


Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Lys Thr 
465                 470                 475                 480 


Glu Asn Thr Lys Asn Asp Asn Lys Val Glu Gly Lys Lys Glu Thr Lys 
                485                 490                 495     


Lys Gln Glu Lys His Lys Ile Glu Ala Ile Ile Glu Ser Lys Ile Lys 
            500                 505                 510         


Asp Met Tyr Ala Leu Tyr Asp Ala Phe Ala Asn Gly Glu Ile Asn Ser 
        515                 520                 525             


Glu Lys Glu Leu Glu Glu Tyr Leu Lys Gly Lys Asp Ile Glu Ile Val 
    530                 535                 540                 


His Leu Pro Lys Gln Met Ile Ala Ile Leu Lys Asn Glu His Lys Asp 
545                 550                 555                 560 


Met Ala Glu Lys Ala Glu Ala Lys Gln Glu Lys Met Lys Leu Ala Thr 
                565                 570                 575     


Glu Asn Arg Leu Lys Thr Leu Asp Lys Gln Leu Lys Gly Lys Ile Gln 
            580                 585                 590         


Asn Gly Lys Arg Tyr Asn Ser Ala Pro Lys Ser Gly Glu Ile Ala Ser 
        595                 600                 605             


Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln Arg Asp Glu 
    610                 615                 620                 


Asn Gly Glu Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln 
625                 630                 635                 640 


Leu Leu Gln Arg Thr Leu Ala Phe Phe Gly Ser Glu His Glu Arg Leu 
                645                 650                 655     


Ala Pro Tyr Phe Lys Gln Thr Lys Leu Ile Glu Ser Ser Asn Pro His 
            660                 665                 670         


Pro Phe Leu Asn Asp Thr Glu Trp Glu Lys Cys Ser Asn Ile Leu Ser 
        675                 680                 685             


Phe Tyr Arg Ser Tyr Leu Lys Ala Lys Lys Asn Phe Leu Glu Ser Leu 
    690                 695                 700                 


Lys Pro Glu Asp Trp Glu Lys Asn Gln Tyr Phe Leu Met Leu Lys Glu 
705                 710                 715                 720 


Pro Lys Thr Asn Arg Lys Thr Leu Val Gln Gly Trp Lys Asn Gly Phe 
                725                 730                 735     


Asn Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg Lys Trp Phe Met 
            740                 745                 750         


Glu His Trp Lys Asn Ile Lys Val Asp Asp Ser Lys Arg Val Gly Leu 
        755                 760                 765             


Val Ala Lys Val Ile Pro Leu Phe Phe Ser Glu Lys Tyr Lys Asp Ser 
    770                 775                 780                 


Val Gln Pro Phe Tyr Asn Tyr Pro Phe Asn Val Gly Asp Val Asn Lys 
785                 790                 795                 800 


Pro Lys Glu Glu Asp Phe Leu His Arg Lys Asp Arg Ile Glu Leu Trp 
                805                 810                 815     


Asp Lys Asn Lys Asp Lys Phe Lys Gly Tyr Lys Ala Lys Lys Lys Phe 
            820                 825                 830         


Lys Glu Met Thr Asp Lys Glu Lys Glu Glu His Arg Ser Tyr Leu Glu 
        835                 840                 845             


Phe Lys Ser Trp Asn Gln Phe Glu Arg Glu Leu Arg Leu Val Arg Asn 
    850                 855                 860                 


Gln Asp Ile Ile Thr Trp Leu Leu Cys Thr Glu Leu Ile Asp Lys Leu 
865                 870                 875                 880 


Lys Ile Asp Glu Leu Asn Ile Lys Glu Leu Lys Lys Leu Arg Leu Lys 
                885                 890                 895     


Asp Ile Asn Thr Asp Thr Ala Lys Glu Glu Lys Asn Asn Ile Leu Asn 
            900                 905                 910         


Arg Val Met Pro Met Glu Leu Pro Ala Thr Val Tyr Glu Val Asn Lys 
        915                 920                 925             


Ala Gly Asn Ile Ile Lys Asn Lys Pro Leu His Thr Ile Tyr Ile Lys 
    930                 935                 940                 


Glu Ala Lys Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu Val 
945                 950                 955                 960 


Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Val Lys Thr Ser Ser 
                965                 970                 975     


Glu Ala Glu Ser Glu Ser Asn Pro Ile Ser Lys Leu Arg Val Glu Ser 
            980                 985                 990         


Glu Leu Gly Lys Tyr Gln Asn Ala  Arg Leu Asp Ile Ile  Glu Asp Met 
        995                 1000                 1005             


Leu Ala  Leu Glu Lys Lys Leu  Ile Asp Lys Tyr Asn  Ser Leu Asp 
    1010                 1015                 1020             


Thr Asp  Asn Phe Ser Leu Asp  Thr Asp Asn Phe His  Asn Met Leu 
    1025                 1030                 1035             


Thr Gly  Trp Leu Lys Leu Lys  Gly Lys Ala Asn Lys  Ala Arg Phe 
    1040                 1045                 1050             


Gln Asn  Glu Val Asp Leu Leu  Val Ala Val Arg Asn  Ala Phe Ser 
    1055                 1060                 1065             


His Asn  Gln Tyr Pro Met Tyr  Asp Glu Asn Leu Phe  Gly Asn Ile 
    1070                 1075                 1080             


Glu Arg  Phe Ser Leu Ser Ser  Ser Asn Ile Ile Glu  Ser Lys Gly 
    1085                 1090                 1095             


Leu Asp  Ile Ala Val Lys Leu  Lys Glu Glu Val Ser  Lys Ala Ala 
    1100                 1105                 1110             


Lys Lys  Ile Gln Asn Glu Glu  Asp Asn Lys Lys Glu  Lys Glu Thr 
    1115                 1120                 1125             


<210>  1814
<211>  1008
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1814

Met Asp Thr Pro Asn Phe Ser Glu Arg Ile Pro Val Ser Leu Gln Ser 
1               5                   10                  15      


His Pro Tyr Tyr Phe Ala His Tyr Leu Asn Met Ala Arg His Asn Ala 
            20                  25                  30          


Tyr Val Ile Leu Glu Tyr Val Asn Arg Glu Leu Ile Lys Pro Gly Lys 
        35                  40                  45              


Asn Leu Asp Glu Asp Asn Leu Ile Gln Ser Thr Val Leu Lys Asp Gly 
    50                  55                  60                  


Tyr Phe Asp Arg Lys Pro Asp Glu Leu Ser His Arg Asn Arg Leu Leu 
65                  70                  75                  80  


Val Gln His Phe Pro Phe Leu Arg Glu Ala Glu Asn Glu Gly Ala Arg 
                85                  90                  95      


Thr Cys Asn Pro Val Ser Tyr Lys Leu Lys Thr Ala Leu Ala Ala Leu 
            100                 105                 110         


Asn Gln Trp Arg Asn Asn Ala Ser His Tyr Pro Leu Asn Gln Asn His 
        115                 120                 125             


Glu Lys Asp Phe Asp Leu Gln Pro Phe Phe Ser Phe Ala Ile Glu Ala 
    130                 135                 140                 


Cys Lys Lys Arg Met Arg Glu Val Phe Gln Pro Asp Asp Phe Tyr Leu 
145                 150                 155                 160 


Leu Glu Thr Asn Glu Lys Gln Phe Tyr Thr Leu His Asn Glu Asn Gly 
                165                 170                 175     


Phe Thr Glu Lys Gly Leu Tyr Cys Phe Ile Cys Phe Phe Leu Glu Lys 
            180                 185                 190         


Lys Tyr Ala Phe Gln Phe Leu Ala Gly Ile Lys Gly Phe Lys Asn Thr 
        195                 200                 205             


Thr Asp Asn Lys Phe Arg Ala Thr Leu Glu Thr Phe Thr Glu His Cys 
    210                 215                 220                 


Cys Arg Leu Pro Lys Pro Lys Leu Asp Ser Ser Asp Ile Lys Leu Asp 
225                 230                 235                 240 


Met Leu Gly Glu Leu Ser Arg Cys Pro Ala Pro Leu Phe Asp Leu Leu 
                245                 250                 255     


Asp Ile Glu Glu Arg Lys Lys Phe Ile Arg Glu Pro Glu Glu Val Lys 
            260                 265                 270         


Pro Asp Glu Ser Gly Asp Arg Glu Glu Val Gln Gln Val Leu Met Lys 
        275                 280                 285             


Arg Tyr Asp Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Glu Glu 
    290                 295                 300                 


Lys Asn Leu Leu Lys Gly Ile Ser Phe His Ile His Ile Gly Arg Trp 
305                 310                 315                 320 


Ile Lys Ser Glu His Thr Lys Lys Ile Met Gly Ala Glu Arg Asp Arg 
                325                 330                 335     


Arg Leu Leu Lys Asp Ile Arg Thr Phe Gly Glu Leu Lys Glu Phe Ser 
            340                 345                 350         


Pro Glu His Ala Pro Asp Tyr Trp Leu Arg Asp Gly Ile Thr Pro Asp 
        355                 360                 365             


Asp Val Asp Gln Phe Ser Pro Gln Tyr Arg Ile Val Gly Asn Arg Ile 
    370                 375                 380                 


Gly Ile Lys Leu Asn Tyr Asn Gly His Asn Arg Trp Ser Val Pro Asp 
385                 390                 395                 400 


Lys Glu Ile Asn Val Lys Pro Asp Ala Ile Ile Ser Thr Tyr Glu Phe 
                405                 410                 415     


Leu Asn Leu Phe Leu Tyr Glu His Leu Tyr Gln Lys Lys Leu Thr Gly 
            420                 425                 430         


Leu Ser Pro Ala Glu Phe Ile Gln Asp Tyr Leu Asp Arg Phe Asn Asn 
        435                 440                 445             


Phe Leu Ser Glu Phe Lys Ala Gly His Ile Arg Pro Val Gly Asp Phe 
    450                 455                 460                 


Ser Leu Glu Lys Arg Arg Gly Gln Gly Asp Glu Pro Asp Leu Thr Ala 
465                 470                 475                 480 


Arg Arg Lys Ser Leu Gln Lys Glu Leu Asp Arg Phe Val Leu Lys Gly 
                485                 490                 495     


Lys Asp Leu Pro Asp Lys Ile Arg Glu Tyr Leu Leu Gly Tyr Lys Gln 
            500                 505                 510         


Lys Ser Glu Lys Lys Gln Ala Lys Trp Ile Leu Gly Gly Met Ile Lys 
        515                 520                 525             


Glu Thr Val Tyr Trp Arg Asn Lys Ala Glu Gln Ser Pro Glu Lys Met 
    530                 535                 540                 


Arg Ser Gly Asp Met Ala Gln Gln Leu Ala Arg Asp Ile Ile Phe Leu 
545                 550                 555                 560 


Thr Pro Pro His Thr Val Lys Glu His Lys Gln Lys Leu Asn Ser Leu 
                565                 570                 575     


Glu Tyr Asp Val Leu Gln Tyr Ala Leu Ala Tyr Phe Ser Ser Asn Arg 
            580                 585                 590         


Glu Lys Leu Tyr Ser Phe Phe Lys Glu His Gln Leu Thr Val Lys Gly 
        595                 600                 605             


Asp Arg Ala His Pro Phe Leu Tyr Lys Ile Arg Leu Asp Glu Cys Gln 
    610                 615                 620                 


Gly Ile Leu Asp Phe Phe Ile Val Tyr Met Gln Gln Lys Glu Lys Trp 
625                 630                 635                 640 


Leu Gly Trp Leu Asp Arg Asn Leu Lys Ser Pro Arg Leu Asn Glu Glu 
                645                 650                 655     


Glu Phe Phe Asn Thr Tyr Ser Tyr Phe Ile Lys Thr Asp Thr Lys Arg 
            660                 665                 670         


Ala Ile Glu Met Asp Tyr Glu Ser Cys Pro Asn Tyr Leu Pro Arg Gly 
        675                 680                 685             


Ile Phe Asn Glu Pro Ile Ala Lys Ala Leu Gln Lys Ala Gly Val Lys 
    690                 695                 700                 


Ile Lys Asp Glu Asp Asn Ala Ser Tyr Ala Leu Ser Val Tyr Ser Asn 
705                 710                 715                 720 


Gly Lys Thr Gln Pro Phe Tyr Asn Lys Glu Arg Tyr Tyr Asn Lys Gly 
                725                 730                 735     


Ile Phe Arg Met Glu Glu Leu Pro Glu Lys Leu Gln Pro Lys Glu Leu 
            740                 745                 750         


Leu Gly Lys Ile Gln Trp Thr Ile Lys Ser Ser Gly Lys Asp Thr Glu 
        755                 760                 765             


Glu Phe Arg Ser Leu Gln Asn Leu Lys Asn Arg Ile Leu Asn Thr Glu 
    770                 775                 780                 


Lys Glu Ile Arg Tyr Val Gln Ser Thr Asp Arg Ala Leu Trp Ile Met 
785                 790                 795                 800 


Val Ala Asp Leu Phe Pro Glu Thr Phe Glu Leu Arg Pro Asp Asp Leu 
                805                 810                 815     


Glu Cys Ile Gly His Asp Leu Ser Asp Asp Leu Leu Ser Arg Pro Tyr 
            820                 825                 830         


Gln Met Lys Glu Lys Val Tyr Asn Tyr Thr Ile Thr Asp Tyr Leu Pro 
        835                 840                 845             


Ile Lys Arg Tyr Gly Glu Phe Arg Arg Phe Leu Lys Asp Arg Arg Leu 
    850                 855                 860                 


Glu Asn Leu Leu Thr Tyr Phe Glu Glu Gly Val Pro Leu His Arg Glu 
865                 870                 875                 880 


Ala Leu Val Ala Glu Leu Glu Ala Tyr Asp Leu Gln Arg Lys Asn Leu 
                885                 890                 895     


Leu Glu Ile Ile Tyr Arg Phe Glu Lys Leu Val Phe Asp Arg His Arg 
            900                 905                 910         


His Glu Leu Thr Phe Ser Gly Glu Gly Glu Asn Gln Tyr Val Asn His 
        915                 920                 925             


Trp Asp Tyr Leu Asp Phe Val Ala Arg Lys Tyr Gly Leu Ser Ala Glu 
    930                 935                 940                 


Val Lys Glu Leu Asn Ser Glu Arg Phe Thr Glu Leu Arg Asn Lys Met 
945                 950                 955                 960 


Leu His Asn Gln Ile Pro Tyr Gln Leu Trp Ile Lys Glu Ala Ile Ala 
                965                 970                 975     


Ala Arg Glu Glu Asn Thr Val Cys Gly Arg Ile Met Gly Met Ile Gly 
            980                 985                 990         


Glu Ile Tyr Glu Arg Met Thr Thr  Glu Ile Glu Lys Gln  Met Gln Val 
        995                 1000                 1005             


<210>  1815
<211>  1180
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1815

Met Glu Thr Pro Glu Lys Val Gly Asn Gly Ile Val Tyr Asp His Thr 
1               5                   10                  15      


Lys Ile Glu Asp Lys His Tyr Phe Gly Gly Tyr Leu Asn Leu Ala Glu 
            20                  25                  30          


Asn Asn Ile Lys Asn Val Leu Asn Ala Leu Lys Asn Arg Phe Gly Lys 
        35                  40                  45              


Ala Ile Asp Lys Lys Glu Lys Glu Glu Phe Lys Lys Glu Phe Asn Glu 
    50                  55                  60                  


Tyr Phe Ser Asp Lys Leu Ala Gln Ala Asp Tyr Gln Glu Arg Val Asp 
65                  70                  75                  80  


Phe Leu Lys Thr Tyr Phe Pro Val Ile His Tyr Ile Asp Leu Pro Pro 
                85                  90                  95      


Ala His Lys Lys Phe Lys Gly Ile Pro Lys Pro Glu Leu Glu Lys Ile 
            100                 105                 110         


Arg Arg Ala Tyr Phe Arg Glu His Phe Phe Leu Leu Thr Asp Ala Ile 
        115                 120                 125             


Asn Ala Leu Arg Asn Phe Tyr Thr His Tyr Tyr His Arg Pro Leu Val 
    130                 135                 140                 


Phe Asp Glu Lys Leu Tyr Ala Leu Leu Asp Glu Ile Phe Leu Asp Val 
145                 150                 155                 160 


Val Leu Gln Val Lys Arg Ala Lys Met Lys Asn Asp Lys Thr Arg His 
                165                 170                 175     


Leu Leu Lys Ala Ser Leu Asn Asp Glu Leu Glu Ala Leu Tyr Lys Ala 
            180                 185                 190         


Lys Glu Lys Gln Val Lys Glu Asp Ile Lys Ala Gly Lys Gln Arg Asn 
        195                 200                 205             


Thr Asp Glu Val Ser Leu Arg Asn Gly Val Leu Asn Asp Ala Phe Tyr 
    210                 215                 220                 


His Leu Leu Phe Gly Lys Asp Glu Val Asn Arg Gln Tyr Lys Ser Lys 
225                 230                 235                 240 


Tyr Val His Glu Thr Glu Ala Glu Asn Lys Ile Val Leu Ser Gln Ser 
                245                 250                 255     


Gly Leu Ile Phe Leu Ser Gly Met Phe Leu Ser Arg Lys Gln Ser Glu 
            260                 265                 270         


Asp Met Arg Ser Arg Ile Lys Gly Phe Lys Ala Lys Thr Val Lys Asp 
        275                 280                 285             


Pro Glu Lys Ser Pro Asp Arg Lys Asn Asn Ser Leu Lys Tyr Met Ala 
    290                 295                 300                 


Thr His Trp Val Phe Gly Tyr Leu Ser Phe Lys Gly Val Lys His Arg 
305                 310                 315                 320 


Ile Ser Thr Gly Phe Asn Leu Glu Thr Leu Leu Met Gln Met Val Asp 
                325                 330                 335     


Glu Leu Ser Lys Val Pro Asp Glu Val Tyr Gln Thr Phe Thr Glu Glu 
            340                 345                 350         


Gln Lys Asn Gln Phe Leu Glu Asp Ile Asn Glu Tyr Val Lys Glu Glu 
        355                 360                 365             


Lys Glu Thr His Ser Leu Asn Glu Ser Ile Gly Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Asp Lys Phe Ala Tyr Phe Ala Leu Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gly Phe Pro Ser Leu Arg Phe Gln Val His Leu Gly 
                405                 410                 415     


Asn Tyr Val His Asp Arg Arg Thr Lys Gln Ile Glu Gly Thr Ala Tyr 
            420                 425                 430         


Glu Thr Glu Arg Val Val Lys Glu Lys Ile Thr Ala Phe Gly Lys Leu 
        435                 440                 445             


Ser Glu Leu Ala Gly Leu Lys Glu Asp Tyr Phe Gln Lys Leu Ala Val 
    450                 455                 460                 


Thr Asp Asn Gln Thr Gly Trp Glu Lys Phe Pro Asn Pro Ser Tyr Asn 
465                 470                 475                 480 


Phe Val Ala Glu Thr Ile Pro Leu Tyr Ile Asn Leu Ala Asn Lys Asp 
                485                 490                 495     


Val Arg Asp Ala His Lys Thr Asn Asn Leu Tyr Arg Gly Arg Arg Glu 
            500                 505                 510         


Ala Tyr Leu Asn Thr Val Ala Lys Arg Asn Ser Gly Lys Pro Ser Thr 
        515                 520                 525             


Glu Gln Ile Arg Ser Asp Ile Asp Ala Gly Ile Ala Asp Thr Ala Arg 
    530                 535                 540                 


Ser Ala Pro Val Ala Ile Leu Ser Leu Asn Glu Leu Pro Ala Leu Leu 
545                 550                 555                 560 


His Glu Leu Leu Val Lys Lys Arg Ser Gly Glu Glu Leu Glu Lys Gln 
                565                 570                 575     


Leu Val Gln Thr Leu Val Lys His Tyr Ala Thr Ile Val Asp Phe Asp 
            580                 585                 590         


Pro Lys Ala Pro Leu Pro Glu Leu Arg Val Thr Lys Lys Leu Ile Lys 
        595                 600                 605             


Ser Ser Asn Glu Pro Ser Val Asn Leu Asp Lys Leu Ile Arg Ala Ile 
    610                 615                 620                 


Gln Thr Glu Val Glu Arg Thr Asp Glu Lys Leu Gln Leu Ile Ala Asp 
625                 630                 635                 640 


His Lys Ala Glu Met Lys Lys Lys Gly Lys Asn Gly Gln Pro Leu Arg 
                645                 650                 655     


Lys Asn Val Phe Thr Asn Arg Glu Cys Gly Glu Glu Ala Arg Trp Leu 
            660                 665                 670         


Ala Asp Asp Leu Lys Arg Leu Met Pro Ala Ala Ala Arg Ala Lys Trp 
        675                 680                 685             


Arg Gly His His His Ser Gln Leu Gln Leu Ser Leu Ala Leu Tyr Glu 
    690                 695                 700                 


His Arg Pro Ala Glu Ala Phe Ser Leu Leu Lys Glu Phe Trp Asn Phe 
705                 710                 715                 720 


Ala Asp Pro Glu Pro Leu Trp Asn Glu Trp Ile Ala Trp Ala Phe Arg 
                725                 730                 735     


Ser Ser Gln Thr Phe Glu Leu Phe Tyr Glu Lys Tyr Leu Thr Arg Arg 
            740                 745                 750         


Arg Lys Leu Phe Ala Ala Trp Ala Glu Gln Leu Glu Gly Phe Arg Asn 
        755                 760                 765             


Ser Thr Ala Gln Leu Asn Lys Phe Ile Lys Gln Gln His Ile Trp Ser 
    770                 775                 780                 


Val Phe His Lys Arg Leu Tyr Ile Ile Asp Thr Thr Glu Asn Gln Lys 
785                 790                 795                 800 


Gln Lys Leu Leu Arg Gln Pro Leu Val Leu Pro Arg Gly Leu Phe Asp 
                805                 810                 815     


Val Lys Pro Thr Tyr Ile Lys Gly Lys Ser Ile Asp Asp Asn Pro Glu 
            820                 825                 830         


Leu Tyr Ala Asp Trp Phe Arg Leu Ala Tyr Tyr Asn Gln Asp Trp Gln 
        835                 840                 845             


Arg Phe Tyr Ala Met Pro Gly Asp Tyr Arg Glu Leu Phe Glu Arg Asn 
    850                 855                 860                 


Thr Asp Lys Asp Thr Glu Arg Thr Lys Asn Lys Tyr Asn Leu Ser Ala 
865                 870                 875                 880 


Glu Glu Gln Leu Asn Leu Phe Lys His Lys His Asn Arg Lys Ile Arg 
                885                 890                 895     


Ala Val Lys Ile Asn Asp Leu Tyr Leu Lys Leu Met Ala Glu Asp Met 
            900                 905                 910         


Leu Asn Arg Leu Leu Gly His Ala Gln Thr Leu His Leu Gln Glu Met 
        915                 920                 925             


Tyr Leu Thr Arg Ala Glu Arg Leu Glu Lys Glu Arg Lys Ala Met Leu 
    930                 935                 940                 


Gln His Gln Arg Ser Ala Gly Asp Thr Ser Pro Val Ile Val Lys Asp 
945                 950                 955                 960 


Ser Phe Val Trp Ser Ile Pro Val Glu Tyr Lys Tyr Thr Gln Thr Thr 
                965                 970                 975     


Glu Ala Gly Glu Lys Val Arg Val Ser Gln Pro Ala Ile Lys Leu Lys 
            980                 985                 990         


Asp Leu Gly Lys Ala Arg Asn Phe  Ile Gln Thr Glu Lys  Val Gln Thr 
        995                 1000                 1005             


Leu Leu  Ser Tyr Asp Lys Glu  Lys Leu Trp Asn Leu  Ala Glu Leu 
    1010                 1015                 1020             


Glu Asp  Glu Leu His Ile Lys  Lys Tyr Ser Tyr Glu  Thr Val Arg 
    1025                 1030                 1035             


Arg Glu  Tyr Leu Leu Lys Glu  Ile Gln Gln Phe Glu  Lys Tyr Ile 
    1040                 1045                 1050             


Leu Asp  Gly Gln Gly Phe Asn  Gly Ala Asp His Pro  Glu Thr Phe 
    1055                 1060                 1065             


Glu Glu  Asn Lys His Pro Asn  Phe Lys Arg Tyr Leu  Ala Glu Gly 
    1070                 1075                 1080             


Ile Leu  Ser Lys Tyr Glu Gln  Val Thr Glu Glu Glu  Arg Asn Trp 
    1085                 1090                 1095             


Phe Thr  Gly Leu Asn Glu Phe  Thr Ile Glu Lys Val  Ser Pro Gly 
    1100                 1105                 1110             


Glu Leu  Asp Thr Lys Gln Pro  Cys Thr Gln His Ala  Phe Leu Leu 
    1115                 1120                 1125             


Leu Leu  Ile Arg Asn Lys Cys  Ala His Asn Gln Leu  Pro Ala Ala 
    1130                 1135                 1140             


Val Tyr  Tyr Lys Arg Met Leu  Ser Gly Leu Pro Leu  Pro Pro Glu 
    1145                 1150                 1155             


Gly Thr  Gly Tyr Ser Gln His  Ile Leu Gln Tyr Val  Arg Tyr Ala 
    1160                 1165                 1170             


Ile Ala  Phe Leu Lys Ala Ala  
    1175                 1180 


<210>  1816
<211>  1180
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1816

Met Glu Thr Pro Glu Lys Val Gly Asn Gly Ile Val Tyr Asp His Thr 
1               5                   10                  15      


Lys Ile Glu Asp Lys His Tyr Phe Gly Gly Tyr Leu Asn Leu Ala Glu 
            20                  25                  30          


Asn Asn Ile Lys Asn Val Leu Asn Ala Leu Lys Asn Arg Phe Gly Lys 
        35                  40                  45              


Ala Ile Asp Lys Lys Glu Lys Glu Glu Phe Lys Lys Glu Phe Asn Glu 
    50                  55                  60                  


Tyr Phe Ser Asp Lys Leu Ala Gln Ala Asp Tyr Gln Glu Arg Val Asp 
65                  70                  75                  80  


Phe Leu Lys Thr Tyr Phe Pro Val Ile His Tyr Ile Asp Leu Pro Pro 
                85                  90                  95      


Ala His Lys Lys Phe Lys Gly Ile Pro Lys Pro Glu Leu Glu Lys Ile 
            100                 105                 110         


Arg Arg Ala Tyr Phe Arg Glu His Phe Phe Leu Leu Thr Asp Ala Ile 
        115                 120                 125             


Asn Ala Leu Arg Asn Phe Tyr Thr His Tyr Tyr His Arg Pro Leu Val 
    130                 135                 140                 


Phe Asp Glu Lys Leu Tyr Ala Leu Leu Asp Glu Ile Phe Leu Asp Val 
145                 150                 155                 160 


Val Leu Gln Val Lys Arg Ala Lys Met Lys Asn Asp Lys Thr Arg His 
                165                 170                 175     


Leu Leu Lys Ala Ser Leu Asn Asp Glu Leu Glu Ala Leu Tyr Lys Ala 
            180                 185                 190         


Lys Glu Lys Gln Val Lys Glu Asp Ile Lys Ala Gly Lys Gln Arg Asn 
        195                 200                 205             


Thr Asp Glu Val Ser Leu Arg Asn Gly Val Leu Asn Asp Ala Phe Tyr 
    210                 215                 220                 


His Leu Leu Phe Gly Lys Asp Glu Val Asn Arg Gln Tyr Lys Ser Lys 
225                 230                 235                 240 


Tyr Val His Glu Thr Glu Ala Glu Asn Lys Ile Val Leu Ser Gln Ser 
                245                 250                 255     


Gly Leu Ile Phe Leu Ser Gly Met Phe Leu Ser Arg Lys Gln Ser Glu 
            260                 265                 270         


Asp Met Arg Ser Arg Ile Lys Gly Phe Lys Ala Lys Thr Val Lys Asp 
        275                 280                 285             


Pro Glu Lys Ser Pro Asp Arg Lys Asn Asn Ser Leu Lys Tyr Met Ala 
    290                 295                 300                 


Thr His Trp Val Phe Gly Tyr Leu Ser Phe Lys Gly Val Lys His Arg 
305                 310                 315                 320 


Ile Ser Thr Gly Phe Asn Leu Glu Thr Leu Leu Met Gln Met Val Asp 
                325                 330                 335     


Glu Leu Ser Lys Val Pro Asp Glu Val Tyr Gln Thr Phe Thr Glu Glu 
            340                 345                 350         


Gln Lys Asn Gln Phe Leu Glu Asp Ile Asn Glu Tyr Val Lys Glu Glu 
        355                 360                 365             


Lys Glu Thr His Ser Leu Asn Glu Ser Ile Gly Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Asp Lys Phe Ala Tyr Phe Ala Leu Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gly Phe Pro Ser Leu Arg Phe Gln Val His Leu Gly 
                405                 410                 415     


Asn Tyr Val His Asp Arg Arg Thr Lys Gln Ile Glu Gly Thr Ala Tyr 
            420                 425                 430         


Glu Thr Glu Arg Val Val Lys Glu Lys Ile Thr Ala Phe Gly Lys Leu 
        435                 440                 445             


Ser Glu Leu Ala Gly Leu Lys Glu Asp Tyr Phe Gln Lys Leu Ala Val 
    450                 455                 460                 


Thr Asp Asn Gln Thr Gly Trp Glu Lys Phe Pro Asn Pro Ser Tyr Asn 
465                 470                 475                 480 


Phe Val Ala Glu Thr Ile Pro Leu Tyr Ile Asn Leu Ala Asn Lys Asp 
                485                 490                 495     


Val Arg Asp Ala His Lys Thr Asn Asn Leu Tyr Arg Gly Arg Arg Glu 
            500                 505                 510         


Ala Tyr Leu Asn Thr Val Ala Lys Arg Asn Ser Gly Lys Pro Ser Thr 
        515                 520                 525             


Glu Gln Ile Arg Ser Asp Ile Asp Ala Gly Ile Ala Asp Thr Ala Arg 
    530                 535                 540                 


Ser Ala Pro Val Ala Ile Leu Ser Leu Asn Glu Leu Pro Ala Leu Leu 
545                 550                 555                 560 


His Glu Leu Leu Val Lys Lys Arg Ser Gly Glu Glu Leu Glu Lys Gln 
                565                 570                 575     


Leu Val Gln Thr Leu Val Lys His Tyr Ala Thr Ile Val Asp Phe Asp 
            580                 585                 590         


Pro Lys Ala Pro Leu Pro Glu Leu Arg Val Thr Lys Lys Leu Ile Lys 
        595                 600                 605             


Ser Ser Asn Glu Pro Ser Val Asn Leu Asp Lys Leu Ile Arg Ala Ile 
    610                 615                 620                 


Gln Thr Glu Val Glu Arg Thr Asp Glu Lys Leu Gln Leu Ile Ala Asp 
625                 630                 635                 640 


His Lys Ala Glu Met Lys Lys Lys Gly Lys Asn Gly Gln Pro Leu Arg 
                645                 650                 655     


Lys Asn Val Phe Thr Asn Arg Glu Cys Gly Glu Glu Ala Arg Trp Leu 
            660                 665                 670         


Ala Asp Asp Leu Lys Arg Leu Met Pro Ala Ala Ala Arg Ala Lys Trp 
        675                 680                 685             


Arg Gly His His His Ser Gln Leu Gln Leu Ser Leu Ala Leu Tyr Glu 
    690                 695                 700                 


His Arg Pro Ala Glu Ala Phe Ser Leu Leu Lys Glu Phe Trp Asn Phe 
705                 710                 715                 720 


Ala Asp Pro Glu Pro Leu Trp Asn Glu Trp Ile Ala Trp Ala Phe Arg 
                725                 730                 735     


Ser Ser Gln Thr Phe Glu Leu Phe Tyr Glu Lys Tyr Leu Thr Arg Arg 
            740                 745                 750         


Arg Lys Leu Phe Ala Ala Trp Ala Glu Gln Leu Glu Gly Phe Arg Asn 
        755                 760                 765             


Ser Thr Ala Gln Leu Asn Lys Phe Ile Lys Gln Gln His Ile Trp Ser 
    770                 775                 780                 


Val Phe His Lys Arg Leu Tyr Ile Ile Asp Thr Thr Glu Asn Gln Lys 
785                 790                 795                 800 


Gln Lys Leu Leu Arg Gln Pro Leu Val Leu Pro Arg Gly Leu Phe Asp 
                805                 810                 815     


Val Lys Pro Thr Tyr Ile Lys Gly Lys Ser Ile Asp Asp Asn Pro Glu 
            820                 825                 830         


Leu Tyr Ala Asp Trp Phe Arg Leu Ala Tyr Tyr Asn Gln Asp Trp Gln 
        835                 840                 845             


Arg Phe Tyr Ala Met Pro Gly Asp Tyr Arg Glu Leu Phe Glu Arg Asn 
    850                 855                 860                 


Thr Asp Lys Asp Thr Glu Arg Thr Lys Asn Lys Tyr Asn Leu Ser Ala 
865                 870                 875                 880 


Glu Glu Gln Leu Asn Leu Phe Lys His Lys His Asn Arg Lys Ile Arg 
                885                 890                 895     


Ala Val Lys Ile Asn Asp Leu Tyr Leu Lys Leu Met Ala Glu Asp Met 
            900                 905                 910         


Leu Asn Arg Leu Leu Gly His Ala Gln Thr Leu His Leu Gln Glu Met 
        915                 920                 925             


Tyr Leu Thr Arg Ala Glu Arg Leu Glu Lys Glu Arg Lys Ala Met Leu 
    930                 935                 940                 


Gln His Gln Arg Ser Ala Gly Asp Thr Ser Pro Val Ile Val Lys Asp 
945                 950                 955                 960 


Ser Phe Val Trp Ser Ile Pro Val Glu Tyr Lys Tyr Thr Gln Thr Thr 
                965                 970                 975     


Glu Ala Gly Glu Lys Val Arg Val Ser Gln Pro Ala Ile Lys Leu Lys 
            980                 985                 990         


Asp Leu Gly Lys Ala Arg Asn Phe  Ile Gln Thr Glu Lys  Val Gln Thr 
        995                 1000                 1005             


Leu Leu  Ser Tyr Asp Lys Glu  Lys Leu Trp Asn Leu  Ala Glu Leu 
    1010                 1015                 1020             


Glu Asp  Glu Leu His Ile Lys  Lys Tyr Ser Tyr Glu  Thr Val Arg 
    1025                 1030                 1035             


Arg Glu  Tyr Leu Leu Lys Glu  Ile Gln Gln Phe Glu  Lys Tyr Ile 
    1040                 1045                 1050             


Leu Asp  Gly Gln Gly Phe Asn  Gly Ala Asp His Pro  Glu Thr Phe 
    1055                 1060                 1065             


Glu Glu  Asn Lys His Pro Asn  Phe Lys Arg Tyr Leu  Ala Glu Gly 
    1070                 1075                 1080             


Ile Leu  Ser Lys Tyr Glu Gln  Val Thr Glu Glu Glu  Arg Asn Trp 
    1085                 1090                 1095             


Phe Thr  Gly Leu Asn Glu Phe  Thr Ile Glu Lys Val  Ser Pro Gly 
    1100                 1105                 1110             


Glu Leu  Asp Thr Lys Gln Pro  Cys Thr Gln His Ala  Phe Leu Leu 
    1115                 1120                 1125             


Leu Leu  Ile Arg Asn Lys Cys  Ala His Asn Gln Leu  Pro Ala Ala 
    1130                 1135                 1140             


Val Tyr  Tyr Lys Arg Met Leu  Ser Gly Leu Pro Leu  Pro Pro Glu 
    1145                 1150                 1155             


Gly Thr  Gly Tyr Ser Gln His  Ile Leu Gln Tyr Val  Arg Tyr Ala 
    1160                 1165                 1170             


Ile Ala  Phe Leu Lys Ala Ala  
    1175                 1180 


<210>  1817
<211>  1148
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1817

Met Asp Asn Ser Thr Ser Lys Ser Phe Lys Arg Phe Phe Glu Phe Lys 
1               5                   10                  15      


Gly Asn Val Ala Pro Ile Ala Glu Lys Ala Asn Arg Asn Phe Asn Ile 
            20                  25                  30          


Lys Asn Leu Asn Pro Ile Asn Thr Gln Gln Arg Leu His Tyr Phe Ala 
        35                  40                  45              


Ile Gly His Val Phe Lys Ser Ile Asp Thr Glu Lys Ile Phe Thr Val 
    50                  55                  60                  


Leu Leu Asp Glu Val Ala Lys Val Lys Lys Pro Thr Lys Phe Ser Ala 
65                  70                  75                  80  


Leu Gln Asn Thr Glu Phe Thr Phe Ile Asn Glu Leu Lys Cys Leu Met 
                85                  90                  95      


Ser Asp Ile Arg Asn Ile Asn Ser His Phe Ile His Asp Phe Glu Lys 
            100                 105                 110         


Ile Lys Ile Asp Ser Ile Asp Lys Asn Ile Ile Glu Phe Leu Lys Gln 
        115                 120                 125             


Ser Phe Glu Leu Ala Val Leu Gln Thr Cys Met Asp Glu Lys Asn Ile 
    130                 135                 140                 


Asn Tyr Glu Glu Phe Thr Gly Gly Gly Asn Pro Glu Lys Glu Ile Val 
145                 150                 155                 160 


Asp Phe Leu Cys Asp Lys Phe Tyr Pro Lys Ile Asp Asn Ser Lys Asp 
                165                 170                 175     


Leu Ser Glu His Gln Lys Leu Ile Ser Asp Phe Lys Lys Lys Ser Lys 
            180                 185                 190         


Asp Glu Ala Ile Asn Glu Ile Leu Phe Ile Asn Val Ser Ser Asp Tyr 
        195                 200                 205             


Asn Trp Asn Ile Phe Glu Thr His Thr Val Phe Lys Ile Ser Lys Gly 
    210                 215                 220                 


Lys Tyr Leu Ser Phe Glu Ala Cys Leu Phe Leu Leu Ala Met Phe Leu 
225                 230                 235                 240 


Tyr Lys Gly Glu Ala Asn Gln Leu Ile Ser Lys Ile Lys Gly Phe Lys 
                245                 250                 255     


Arg Asn Asp Asp Asn Lys Phe Met Ser Lys Arg Asn Leu Phe Thr Phe 
            260                 265                 270         


Phe Ser Lys Lys Phe Ser Ser Gln Asp Ile Asp Ser Glu Glu Asn His 
        275                 280                 285             


Leu Val Lys Phe Arg Asp Leu Val Gln Tyr Leu Asn His Tyr Pro Thr 
    290                 295                 300                 


Val Trp Asn Lys Tyr Leu Glu Leu Gly Ser Asn Asn Pro Ile Met Thr 
305                 310                 315                 320 


Glu Arg Leu Lys Glu Lys Ile Ile Glu Leu Glu Ile Lys Arg Cys Phe 
                325                 330                 335     


Pro Glu Leu Ala Ser Asn Ser Ser Phe Asn Gln Phe Ala Ile Asn Tyr 
            340                 345                 350         


Ile Phe Lys Asn Gly Lys Ile Ile Glu Cys Glu Asn Asn Asn Ile Tyr 
        355                 360                 365             


Leu Asp Ile Ile Asn Lys Asn Asp Glu Val Arg Lys Ile Tyr Phe Ser 
    370                 375                 380                 


Ile Lys Asn Asn Glu Phe Asn Arg Ser Glu Phe Lys Asp Asn Ser Phe 
385                 390                 395                 400 


Lys Met Phe Ala Leu Lys Tyr Val Val Lys Glu Tyr Tyr Lys Glu Asn 
                405                 410                 415     


Lys Ala Tyr Ala Asp Tyr Leu Thr Lys Gln Ile Lys Asp Lys Glu Lys 
            420                 425                 430         


Thr Phe Asp Glu Glu Leu Ile Thr Asn Lys Lys Val Glu Lys Leu Lys 
        435                 440                 445             


Lys Gln Ile Ser Gln Asn Leu Asn Phe Ile Phe Tyr Gly Arg Asn Gln 
    450                 455                 460                 


Asp Arg Phe Met Glu Phe Ala Thr Arg Tyr Leu Ala Glu Thr Gly Tyr 
465                 470                 475                 480 


Phe Gly Lys Asp Ala Lys Phe Lys Met Tyr Glu Phe Phe Thr Thr Asp 
                485                 490                 495     


Glu Gln Ile Glu Glu Ile Asp Arg Leu Lys Arg Thr Ile Ser Lys Lys 
            500                 505                 510         


Glu Phe Asp Lys Leu Lys Phe His Gln Gly Lys Leu Val His Cys Ser 
        515                 520                 525             


Thr Tyr Ala Asp His Ile Ala Lys Tyr Lys Asn Trp Asp Thr Pro Phe 
    530                 535                 540                 


Val Val Glu Asn Asn Ala Val Gln Leu Thr Val Cys Phe Asp Asn Gly 
545                 550                 555                 560 


Gln Arg Lys Ile Leu Ser Ile Gln Arg Asn Leu Met Pro Tyr Phe Leu 
                565                 570                 575     


Glu Asp Ala Leu Tyr Asn Met Gln Asn Asp Lys Ile Glu Gly Ala Gly 
            580                 585                 590         


Lys Ile Leu Ile Glu Asn Tyr Tyr Asn Tyr His Lys Glu Gly Phe Glu 
        595                 600                 605             


Lys Ser Arg Leu Thr Leu Lys Gln Asn Asp Thr Ile Ser Leu Leu Glu 
    610                 615                 620                 


Lys Ala Thr Phe Lys Lys Ile Leu Pro Lys Arg Leu Leu His Arg Tyr 
625                 630                 635                 640 


Ser Pro Ala Val Gln Asn Asn Leu Pro Glu His Ser Thr Tyr Lys Gln 
                645                 650                 655     


Ile Leu Thr Lys Thr Lys Glu Ala Glu Glu Arg Tyr Val Lys Leu Leu 
            660                 665                 670         


Glu Lys Ala Lys Lys Asp Gly Tyr Glu Glu Asp Phe Leu Lys Arg Asn 
        675                 680                 685             


Lys Gly Lys Gln Phe Lys Leu Arg Phe Ile Arg Lys Ala Trp Asn Ile 
    690                 695                 700                 


Leu Phe Phe Lys Asp His Tyr Leu Lys Gln Val Gln Phe Ser Gly His 
705                 710                 715                 720 


His Arg Arg Phe Asn Ile Ser Arg Glu Glu Phe Asn Asp Phe Ser Lys 
                725                 730                 735     


Trp Met Phe Ala Phe Asp Glu Thr Pro Lys Tyr Lys Asp Tyr Leu Met 
            740                 745                 750         


Ile Leu Phe Glu Gln Lys Gly Phe Leu Glu Ile Ser Asn Phe Arg Thr 
        755                 760                 765             


Leu Phe Val Asn Ser Ser Ser Leu Asp Gly Leu Tyr Gly Lys Thr Lys 
    770                 775                 780                 


Ala Ile Tyr Glu Gly Trp Met Gln Asn Asn Asn Thr Asn Glu Lys Asn 
785                 790                 795                 800 


Pro Asp Lys Tyr Ser Leu Lys Asn Tyr Glu Lys Phe Phe Thr Asp Glu 
                805                 810                 815     


Leu Phe Tyr Ile Asn Val Ser His Phe Ile Ala Tyr Leu Asp Ile Ile 
            820                 825                 830         


Asn Lys Ile Arg Arg Asn Glu Lys Gly Gly Ile Ile Tyr Pro Cys Leu 
        835                 840                 845             


Glu Asn Glu Lys His Leu Ile Thr Glu Tyr Tyr Tyr Lys Val Lys Leu 
    850                 855                 860                 


Glu Glu Asn Glu Leu Lys Asn Cys Lys Lys Leu Phe Asn Lys Leu Met 
865                 870                 875                 880 


Ser Ala Lys Leu Glu Asp Ala Leu Leu Tyr Glu Ile Ser Met Tyr Tyr 
                885                 890                 895     


Leu Gly Ile Asp Asn Thr Ile Val Gln Lys Ala Arg Thr Asn Val Thr 
            900                 905                 910         


Asn Leu Leu Asn Gln Asp Val Val Phe Asn Ile Asn Asp Ala Asn Ser 
        915                 920                 925             


Asn His Leu Tyr Asp Leu Ser Ile Pro Phe Asn Lys Ile Asp Ser Tyr 
    930                 935                 940                 


Val Glu Leu Ile Lys His Lys Glu Asp Gln Glu Asn Asp Lys Lys Asn 
945                 950                 955                 960 


Lys Lys Thr Ser Phe Leu Gly Asn Met Pro Ser Tyr Ile Val Asn Val 
                965                 970                 975     


Ile Cys Lys Glu Thr Lys Asn Lys Glu Ser Cys Ser Ile Cys Asn Lys 
            980                 985                 990         


Tyr Ile Asn Phe Lys Lys Leu Asp  Phe Asp Asp Leu Asn  Lys Ile Asn 
        995                 1000                 1005             


Asn His  Ile Leu Ser Asn Ser  Val Lys Phe Thr Gln  Val Ala Leu 
    1010                 1015                 1020             


Ser Phe  Glu Glu Tyr Phe Ile  Phe Asn Glu Lys Lys  Ser Ile Ile 
    1025                 1030                 1035             


Lys Asn  Asn Arg Ile Asp Val  Asp Glu Phe Ser Phe  Trp Asn Ala 
    1040                 1045                 1050             


Tyr Phe  Ser Asp Ser Gly Leu  Thr Arg Lys Lys Ala  Phe His Phe 
    1055                 1060                 1065             


Gly Val  Pro Lys Glu Ser Tyr  Asp Asp Ile Ile Ala  Arg Met Glu 
    1070                 1075                 1080             


Asn Lys  Phe Val Lys Glu Gln  Ile Arg Pro Ser Leu  Pro Leu Asp 
    1085                 1090                 1095             


Tyr Asn  Ser Phe Asn Lys Gln  Gln Lys Ser Ile Cys  Asp Ala Leu 
    1100                 1105                 1110             


Leu Lys  Ser Ile His Ser Ser  Tyr Phe Asn His Arg  Glu Lys Asp 
    1115                 1120                 1125             


Lys Lys  Lys Lys Arg Asn Glu  Ala Asn Asn Met Tyr  Tyr Lys Glu 
    1130                 1135                 1140             


Val Ile  Leu Lys Lys 
    1145             


<210>  1818
<211>  1145
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1818

Met Glu Thr Leu Thr Ile Pro Glu Val Ile Lys Cys Arg Thr Leu Ser 
1               5                   10                  15      


Asp Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Ile Ala Lys Glu Phe Asp Leu Pro Leu 
        35                  40                  45              


Leu Ala Glu Glu Gly His Leu Lys Asn Ser Phe Leu Cys Lys Lys Glu 
    50                  55                  60                  


His Asn Lys Val Asn Trp Asn His Val Tyr Ser Arg Thr Lys Arg Phe 
65                  70                  75                  80  


Leu Ala Val Leu Lys Val Phe Asp Ala Glu Thr Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Lys Thr Ile Asn Trp Glu Gly Lys Asp Phe Ala Ser Met Ser Asp 
            100                 105                 110         


Ile Leu Lys Ile Val Phe Gly Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Thr Ile Arg Lys Thr Ala Val 
    130                 135                 140                 


Ser Ala Glu Met Ala Leu Phe Leu Thr Thr Asn Phe Arg Arg Ala Ile 
145                 150                 155                 160 


Glu Tyr Thr Lys Glu Arg Phe Lys Gly Val Leu Asn Asp Glu Asp Tyr 
                165                 170                 175     


Gln Leu Val Ala Ser Lys Lys Val Leu Glu Ala Asn Ser Thr Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Arg Phe Ile Gly Ile Ile Thr Gly Leu Lys Gly Thr Gln Asn 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro His Asp Arg Phe Gln Ser Asp Asn Pro Arg Gln Ala Phe Ser 
                245                 250                 255     


Leu Asp Leu Ile Asn Glu Leu Asn Arg Cys Pro Lys Val Leu Tyr Asn 
            260                 265                 270         


Ala Ile Thr Glu Glu Gly Lys Gln Lys Leu Arg Ser Ile Pro Gly Glu 
        275                 280                 285             


Leu Glu Asn Lys Asn Leu His Asp Asn Asn Thr Lys Lys Glu Ala Lys 
    290                 295                 300                 


Ile Glu Ala Glu Ala Tyr Glu Leu Tyr Ile Glu Ser Leu Thr Arg Gln 
305                 310                 315                 320 


Ile Arg Tyr Ser Asn Arg Phe Pro Asp Phe Ala Leu Lys Phe Ile Asp 
                325                 330                 335     


Glu Thr Asp Ile Phe Ser Glu Phe Arg Phe Gln Ile Asp Leu Gly Lys 
            340                 345                 350         


Leu Leu Val Asp Glu Tyr Leu Lys Phe Phe Asn Gly Glu His Val Gln 
        355                 360                 365             


Arg Arg Ile Val Glu Asn Ala Lys Ala Phe Gly Lys Leu Ile Asp Phe 
    370                 375                 380                 


Asn Asp Glu Ala Lys Val Met Thr Arg Ile Gly Asn Gly His Phe Ser 
385                 390                 395                 400 


Lys Arg Phe Glu Gln Phe Ala Pro Phe Tyr Asn Thr Glu Asp Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Arg His His Val Thr Ala Lys Leu Gly Pro Asp Ser 
            420                 425                 430         


Lys Gly Glu Pro Glu Lys Lys Leu Leu Gln Pro Leu Pro Glu Ala Phe 
        435                 440                 445             


Leu Ser Leu His Glu Leu Pro Lys Val Ile Leu Leu Asp Tyr Leu Gln 
    450                 455                 460                 


Lys Gly Glu Pro Glu Lys Leu Ile Asn Asp Phe Ile Leu Ile Asn Asn 
465                 470                 475                 480 


Ser Lys Leu Met Asn Met Ser Phe Ile Glu Ala Val Lys Thr Gln Leu 
                485                 490                 495     


Pro Pro Glu Trp Asp Glu Phe Gln Arg Arg Thr Gly Ser Lys Asn Glu 
            500                 505                 510         


Met Pro Tyr Asn Glu Lys Thr Leu Ala Tyr Leu Leu Gln Arg Lys Gln 
        515                 520                 525             


Ile Leu Asn Lys Ile Leu Ala Glu Phe Gln Leu Asn Asp Lys Gln Ile 
    530                 535                 540                 


Pro Gly Arg Ile Leu Asp Tyr Trp Leu Asn Ile Ala Asp Val Glu Glu 
545                 550                 555                 560 


Glu Arg Ala Val Ser Asp Arg Ile Lys Ser Ile Lys Arg Asp Cys Met 
                565                 570                 575     


Ser Arg Leu Arg Ala Leu Gly Lys Phe Lys Ile Asp Arg Asn Arg Asn 
            580                 585                 590         


Lys Ile Pro Lys Ile Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile 
        595                 600                 605             


Val Asp Met Val Val Ser Glu Gly Lys Lys His Lys Ile Thr Ser Phe 
    610                 615                 620                 


Tyr Tyr Glu Lys Met Gln Asp Cys Leu Ser Leu Phe Ala Asp Pro Leu 
625                 630                 635                 640 


Lys Arg Gln Leu Phe Ile His Ile Ile Thr Asn Glu Leu Arg Leu Asn 
                645                 650                 655     


Asp Ser Gly Gly His Pro Phe Leu Phe Lys Leu Asn Met Arg Gln Ile 
            660                 665                 670         


Asn Cys Thr Ser Asp Phe Tyr Glu Ile Tyr Leu Gln Glu Lys Gly His 
        675                 680                 685             


Lys Met Val Pro Glu Lys Asn Leu Lys Thr Gly Lys Val Val Asn Thr 
    690                 695                 700                 


Asp His Ser Trp Met Ala Leu Thr Phe Tyr Lys Leu Glu Phe Asn Asp 
705                 710                 715                 720 


Lys Val Asp Lys Leu Met Thr Val Val Lys Leu Pro Leu Asn Lys Leu 
                725                 730                 735     


Asn Leu Pro Phe Thr Leu Arg Gln Leu Asn Ala Lys Thr Thr Tyr Thr 
            740                 745                 750         


Leu Glu Gln Trp Leu Lys Asn Leu Thr Leu Gly Lys Lys Pro Asp Asp 
        755                 760                 765             


Gly Lys His Pro Val Asn Leu Pro Thr Asn Leu Phe Asp Glu Lys Leu 
    770                 775                 780                 


Ser Asp Leu Leu Arg Gln Asp Leu Asp Asn Asn Lys Ile Ala Tyr Arg 
785                 790                 795                 800 


Pro Tyr Ala Asn Trp Asn Glu Leu Phe Lys Ile Trp Trp Ile Ser Arg 
                805                 810                 815     


Asn Asp Ser Leu Gln Arg Phe Tyr Asn Ala Glu Arg Glu Tyr His Ile 
            820                 825                 830         


Phe Asn Glu Lys Val Asn Phe Tyr Pro Asn Arg Lys Glu Asn Phe Ala 
        835                 840                 845             


Asp Tyr Tyr Gln His Ala Val Lys Val Ala Phe Gln Lys Lys Arg Asn 
    850                 855                 860                 


Glu Arg Ile Ile Glu Gln Arg Ile Asn Lys Tyr Leu Pro Asp Ile Leu 
865                 870                 875                 880 


Phe Glu Gln Val Glu Lys Thr Phe Lys His Thr Ile Ala Glu Thr Glu 
                885                 890                 895     


Lys Glu Ile Arg Ile Leu Gln Glu Glu Asp Arg Ile Met Leu Leu Met 
            900                 905                 910         


Leu Glu Gly Leu Met Glu Asp Gly Asn Lys Gln Gln Leu Lys Leu Ser 
        915                 920                 925             


Glu Ile Lys Thr Leu Gln Asn Ala Thr Ile Asn Ile Arg Gln Leu Val 
    930                 935                 940                 


Pro Gly Lys Leu Ser Phe Asp Asp Ser Gly Glu Ala Ile Lys Asp Ser 
945                 950                 955                 960 


Thr Asn Pro Glu Ile Val Arg Thr Val Ser Val Ser Ile Lys Arg Ile 
                965                 970                 975     


Glu Tyr Asn Leu Leu Pro Lys Tyr Val Ala Asp Gly Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Pro Asp Glu  Glu Ile Gln Met Glu  Arg Leu Lys 
        995                 1000                 1005             


Thr Glu  Phe Asp Thr Tyr Asn  Lys Val Arg Gln Val  Val Leu Asp 
    1010                 1015                 1020             


Leu Ser  Phe Lys Leu Glu Lys  Met Ile Ile Glu Lys  Gly His Lys 
    1025                 1030                 1035             


Asp Arg  Ile Asn Gln Leu Cys  Thr Gly Ala Thr Gly  Glu Leu Leu 
    1040                 1045                 1050             


Thr Gly  Asn Ile Cys His His  Thr Tyr Leu Thr Trp  Leu Lys Asp 
    1055                 1060                 1065             


Lys Glu  Met Ile Asp Asn Glu  Thr Phe Ile Phe Met  Asn Met Val 
    1070                 1075                 1080             


Gln His  Cys Phe Ser His Asn  Gln Tyr Pro Gln Lys  Lys Thr Met 
    1085                 1090                 1095             


Glu Arg  Ile Ile Asn His Trp  Glu Pro Asp Arg Phe  Ala Leu Thr 
    1100                 1105                 1110             


Ile Ala  Ala Thr Tyr Asn Gln  Lys Ile Ala Gly Ile  Leu Glu Asp 
    1115                 1120                 1125             


Ile Gly  Thr Phe Pro Phe Ile  Arg Ser Arg Lys Thr  Met Pro Asp 
    1130                 1135                 1140             


Val Val  
    1145 


<210>  1819
<211>  1150
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1819

Val Lys Met Glu Asp Asp Lys Lys Thr Thr Glu Ser Thr Asn Met Leu 
1               5                   10                  15      


Asp Asn Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Val Tyr Ile Thr Val Asn His Ile Asn Lys Val Leu Glu Leu Lys Asn 
        35                  40                  45              


Lys Lys Asp Gln Asp Ile Ile Ile Asp Asn Asp Gln Asp Ile Leu Ala 
    50                  55                  60                  


Ile Lys Thr His Trp Glu Lys Val Asn Gly Asp Leu Asn Lys Thr Glu 
65                  70                  75                  80  


Arg Leu Arg Glu Leu Met Thr Lys His Phe Pro Phe Leu Glu Thr Ala 
                85                  90                  95      


Ile Tyr Thr Lys Asn Lys Glu Asp Lys Lys Glu Val Lys Gln Glu Lys 
            100                 105                 110         


Gln Ala Lys Ala Gln Ser Phe Asp Ser Leu Lys His Cys Leu Phe Leu 
        115                 120                 125             


Phe Leu Glu Lys Leu Gln Glu Ala Arg Asn Tyr Tyr Ser His Tyr Lys 
    130                 135                 140                 


Tyr Ser Glu Ser Thr Lys Glu Pro Met Leu Glu Lys Glu Leu Leu Lys 
145                 150                 155                 160 


Lys Met Tyr Asn Ile Phe Asp Asp Asn Ile Gln Leu Val Ile Lys Asp 
                165                 170                 175     


Tyr Gln His Asn Lys Asp Ile Asn Pro Asp Glu Asp Phe Lys His Leu 
            180                 185                 190         


Asp Arg Thr Glu Glu Asp Phe Asn Tyr Tyr Phe Thr Arg Asn Lys Lys 
        195                 200                 205             


Gly Asn Ile Thr Ala Ser Gly Leu Leu Phe Phe Val Ser Leu Phe Leu 
    210                 215                 220                 


Glu Lys Lys Asp Ala Ile Trp Met Gln Gln Lys Leu Arg Gly Phe Lys 
225                 230                 235                 240 


Asp Asn Arg Glu Ser Lys Lys Lys Met Thr His Glu Val Phe Cys Arg 
                245                 250                 255     


Arg Arg Met Leu Leu Pro Lys Leu Arg Leu Glu Ser Thr Gln Thr Gln 
            260                 265                 270         


Asp Trp Ile Leu Leu Asp Met Leu Asn Glu Leu Ile Arg Cys Pro Lys 
        275                 280                 285             


Ser Leu Tyr Glu Arg Leu Gln Gly Asp Asp Arg Lys Lys Phe Asn Val 
    290                 295                 300                 


Pro Phe Asp Pro Ala Asp Glu Asn Tyr Asp Ala Glu Gln Glu Pro Phe 
305                 310                 315                 320 


Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Ala Leu 
                325                 330                 335     


Arg Tyr Phe Asp Tyr Asn Glu Ile Phe Ala Asn Leu Arg Phe Gln Ile 
            340                 345                 350         


Asp Leu Gly Thr Tyr His Phe Ser Ile Tyr Lys Lys Leu Ile Gly Gly 
        355                 360                 365             


Gln Lys Glu Asp Arg His Leu Thr His Lys Leu Tyr Gly Phe Glu Arg 
    370                 375                 380                 


Ile Gln Glu Phe Ala Lys Gln Asn Arg Thr Asp Glu Trp Lys Ala Ile 
385                 390                 395                 400 


Val Lys Asp Leu Asp Thr Tyr Glu Thr Ser Asn Glu Arg Tyr Ile Ser 
                405                 410                 415     


Glu Thr Thr Pro His Tyr His Leu Glu Asn Gln Lys Ile Gly Ile Arg 
            420                 425                 430         


Phe Arg Asn Asp Asn Asp Glu Ile Trp Pro Ser Leu Lys Thr Asn Gly 
        435                 440                 445             


Glu Asn Asn Glu Lys Arg Lys Tyr Lys Leu Asp Lys Gln Tyr Gln Ala 
    450                 455                 460                 


Glu Ala Phe Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr 
465                 470                 475                 480 


Leu Leu Leu Lys Met Glu Asn Thr Asp Asn Gly Lys Glu Asn Asn Glu 
                485                 490                 495     


Val Gly Thr Lys Lys Lys Arg Asn Lys Asn Asn Glu Gln Glu Lys His 
            500                 505                 510         


Lys Ile Glu Glu Ile Ile Glu Asn Lys Ile Lys Asp Ile Tyr Ala Leu 
        515                 520                 525             


Tyr Asp Ala Phe Ala Asn Gly Glu Ile Asn Ser Glu Glu Glu Leu Lys 
    530                 535                 540                 


Glu Tyr Leu Lys Gly Lys Asp Ile Glu Ile Val His Leu Pro Lys Gln 
545                 550                 555                 560 


Met Val Ala Ile Leu Tyr Asp Glu His Lys Asp Met Val Glu Glu Ala 
                565                 570                 575     


Lys Arg Lys Gln Lys Glu Met Val Lys Asp Thr Lys Lys Leu Leu Ala 
            580                 585                 590         


Thr Leu Glu Lys Gln Thr Gln Gly Glu Ile Glu Asp Gly Gly Arg Asn 
        595                 600                 605             


Ile Arg Leu Leu Lys Ser Gly Glu Ile Ala Arg Trp Leu Val Asn Asp 
    610                 615                 620                 


Met Met Arg Phe Gln Pro Val Gln Lys Asp Asn Glu Gly Asn Pro Leu 
625                 630                 635                 640 


Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln Met Leu Gln Arg Ser 
                645                 650                 655     


Leu Ala Leu Tyr Asn Lys Glu Glu Lys Pro Thr Arg Tyr Phe Arg Gln 
            660                 665                 670         


Val Asn Leu Ile Asn Ser Ser Asn Pro His Pro Phe Leu Lys Trp Thr 
        675                 680                 685             


Lys Trp Glu Glu Cys Asn Asn Ile Leu Ser Phe Tyr Arg Ser Tyr Leu 
    690                 695                 700                 


Thr Lys Lys Ile Glu Phe Leu Asn Lys Leu Lys Pro Glu Asp Trp Glu 
705                 710                 715                 720 


Lys Asn Gln Tyr Phe Leu Lys Leu Lys Glu Pro Lys Ile Asn Arg Glu 
                725                 730                 735     


Thr Leu Val Gln Gly Trp Lys Asn Gly Phe Asn Leu Pro Arg Gly Ile 
            740                 745                 750         


Phe Thr Glu Pro Ile Arg Glu Trp Phe Lys Arg His Gln Asn Asp Ser 
        755                 760                 765             


Lys Glu Tyr Glu Asn Val Glu Ala Leu Asp Arg Val Gly Leu Val Thr 
    770                 775                 780                 


Lys Val Ile Pro Leu Phe Phe Lys Glu Glu Asp Phe Lys Asp Lys Glu 
785                 790                 795                 800 


Glu Tyr Leu Lys Lys Asp Ala Gln Lys Glu Ile Asn Asn Cys Val Gln 
                805                 810                 815     


Pro Phe Tyr Ser Leu Pro Tyr Asn Val Gly Asn Ile His Lys Pro Asp 
            820                 825                 830         


Glu Lys Asp Phe Leu Pro Ser Glu Glu Arg Lys Lys Leu Trp Gly Asp 
        835                 840                 845             


Lys Lys Tyr Lys Phe Lys Gly Tyr Lys Ala Lys Val Lys Ser Lys Lys 
    850                 855                 860                 


Leu Thr Asp Lys Glu Lys Glu Glu Tyr Arg Ser Tyr Leu Glu Phe Gln 
865                 870                 875                 880 


Ser Trp Asn Lys Phe Glu Arg Glu Leu Arg Leu Val Arg Asn Gln Asp 
                885                 890                 895     


Ile Val Thr Trp Leu Leu Cys Thr Glu Leu Ile Asp Lys Leu Lys Val 
            900                 905                 910         


Glu Gly Leu Asn Val Glu Glu Leu Gln Lys Leu Arg Leu Lys Asp Ile 
        915                 920                 925             


Asp Thr Asp Thr Ala Lys Gln Glu Lys Asn Asn Ile Leu Asn Arg Val 
    930                 935                 940                 


Met Pro Met Gln Leu Pro Val Thr Val Tyr Glu Ile Asp Asp Ser His 
945                 950                 955                 960 


Asn Ile Val Lys Asp Arg Pro Leu His Thr Val Tyr Ile Glu Glu Thr 
                965                 970                 975     


Lys Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys Asp 
            980                 985                 990         


Arg Arg Leu Asn Gly Leu Phe Ser  Phe Val Asp Thr Ser  Ser Glu Thr 
        995                 1000                 1005             


Glu Leu  Lys Ser Lys Pro Ile  Ser Lys Ser Val Val  Glu Tyr Glu 
    1010                 1015                 1020             


Leu Gly  Glu Tyr Gln Asn Ala  Arg Ile Glu Ile Ile  Glu Asp Met 
    1025                 1030                 1035             


Leu Ala  Leu Glu Glu Thr Leu  Ile Glu Lys Asp Lys  Asn Leu Pro 
    1040                 1045                 1050             


Thr Asn  Asn Phe Ser Asp Met  Leu Asn Gly Trp Leu  Glu Gly Lys 
    1055                 1060                 1065             


Asp Glu  Ala Asp Lys Ala Ser  Phe Gln Asn Asp Val  Asp Leu Leu 
    1070                 1075                 1080             


Thr Ala  Val Arg Asn Ala Phe  Ser His Asn Gln Tyr  Pro Met Arg 
    1085                 1090                 1095             


Asn Arg  Ile Ala Phe Ala Asn  Ile Asn Pro Phe Ser  Leu Ser Ser 
    1100                 1105                 1110             


Ala Asn  Thr Ser Glu Glu Lys  Gly Leu Gly Ile Ala  Asn Gln Leu 
    1115                 1120                 1125             


Lys Asp  Lys Thr Lys Glu Thr  Ile Glu Lys Ile Ile  Lys Ile Glu 
    1130                 1135                 1140             


Lys Pro  Ile Glu Thr Lys Glu  
    1145                 1150 


<210>  1820
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1820

Leu Gln Lys Gln Asp Lys Leu Phe Val Asp Arg Lys Lys Asn Ala Ile 
1               5                   10                  15      


Phe Ala Phe Pro Lys Tyr Ile Thr Ile Met Glu Asn Lys Glu Lys Pro 
            20                  25                  30          


Glu Pro Ile Tyr Tyr Glu Leu Thr Asp Lys His Phe Trp Ala Ala Phe 
        35                  40                  45              


Leu Asn Leu Ala Arg His Asn Val Tyr Thr Thr Ile Asn His Ile Asn 
    50                  55                  60                  


Arg Arg Leu Glu Ile Ala Glu Leu Lys Asp Asp Gly Tyr Met Met Asp 
65                  70                  75                  80  


Ile Lys Gly Ser Trp Asn Glu Gln Ala Lys Lys Leu Asp Lys Lys Val 
                85                  90                  95      


Arg Leu Arg Asp Leu Leu Met Lys His Phe Pro Phe Leu Glu Ala Ala 
            100                 105                 110         


Ala Tyr Glu Met Thr Asn Ser Lys Ser Pro Asn Asn Lys Glu Gln Arg 
        115                 120                 125             


Glu Lys Glu Gln Ser Glu Ala Leu Ser Leu Asn Asn Leu Lys Asn Val 
    130                 135                 140                 


Leu Phe Ile Phe Leu Glu Lys Leu Gln Val Leu Arg Asn Tyr Tyr Ser 
145                 150                 155                 160 


His Tyr Lys Tyr Ser Glu Glu Ser Pro Lys Pro Ile Phe Glu Thr Ser 
                165                 170                 175     


Leu Leu Lys Asn Met Tyr Lys Val Phe Asp Ala Asn Val Arg Leu Val 
            180                 185                 190         


Lys Arg Asp Tyr Met His His Glu Asn Ile Asp Met Gln Arg Asp Phe 
        195                 200                 205             


Thr His Leu Asn Arg Lys Lys Gln Val Gly Arg Thr Lys Asn Ile Ile 
    210                 215                 220                 


Asp Ser Pro Asn Phe His Tyr His Phe Ala Asp Lys Glu Gly Asn Met 
225                 230                 235                 240 


Thr Ile Ala Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Asp Lys Lys 
                245                 250                 255     


Asp Ala Ile Trp Met Gln Lys Lys Leu Lys Gly Phe Lys Asp Gly Arg 
            260                 265                 270         


Asn Leu Arg Glu Gln Met Thr Asn Glu Val Phe Cys Arg Ser Arg Ile 
        275                 280                 285             


Ser Leu Pro Lys Leu Lys Leu Glu Asn Val Gln Thr Lys Asp Trp Met 
    290                 295                 300                 


Gln Leu Asp Met Leu Asn Glu Leu Val Arg Cys Pro Lys Ser Leu Tyr 
305                 310                 315                 320 


Glu Arg Leu Arg Glu Lys Asp Arg Glu Ser Phe Lys Val Pro Phe Asp 
                325                 330                 335     


Ile Phe Ser Asp Asp Tyr Asp Ala Glu Glu Glu Pro Phe Lys Asn Thr 
            340                 345                 350         


Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe 
        355                 360                 365             


Asp Leu Asn Glu Ile Phe Glu Gln Leu Arg Phe Gln Ile Asp Leu Gly 
    370                 375                 380                 


Thr Tyr His Phe Ser Ile Tyr Asn Lys Arg Ile Gly Asp Glu Asp Glu 
385                 390                 395                 400 


Val Arg His Leu Thr His His Leu Tyr Gly Phe Ala Arg Ile Gln Asp 
                405                 410                 415     


Phe Ala Pro Gln Asn Gln Pro Glu Glu Trp Arg Lys Leu Val Lys Asp 
            420                 425                 430         


Leu Asp His Phe Glu Thr Ser Gln Glu Pro Tyr Ile Ser Lys Thr Ala 
        435                 440                 445             


Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Lys Phe Cys Ser 
    450                 455                 460                 


Thr His Asn Asn Leu Phe Pro Ser Leu Lys Thr Glu Lys Thr Cys Asn 
465                 470                 475                 480 


Gly Arg Ser Lys Phe Asn Leu Gly Thr Gln Phe Thr Ala Glu Ala Phe 
                485                 490                 495     


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu 
            500                 505                 510         


Thr Lys Asp His Pro Lys Gly Lys Gly Ile Asn Lys Ile Glu Lys Ile 
        515                 520                 525             


Ile Arg Lys Glu Ile Ser Asn Ile Tyr Ala Ile Tyr Asp Ala Phe Ala 
    530                 535                 540                 


Asn Asn Glu Ile Asn Ser Ile Ala Asp Leu Thr Arg Arg Leu Gln Asn 
545                 550                 555                 560 


Thr Asn Ile Leu Gln Gly His Leu Pro Lys Gln Met Ile Ser Ile Leu 
                565                 570                 575     


Glu Gly Arg Gln Lys Asp Met Glu Lys Glu Ala Glu Arg Lys Ile Gly 
            580                 585                 590         


Glu Met Ile Asp Asp Thr Gln Arg Arg Leu Asp Leu Leu Cys Lys Gln 
        595                 600                 605             


Thr Asn Gln Lys Ile Arg Ile Gly Lys Arg Asn Ala Gly Leu Leu Lys 
    610                 615                 620                 


Ser Gly Lys Ile Ala Asp Trp Leu Val Asn Asp Met Met Arg Phe Gln 
625                 630                 635                 640 


Pro Val Gln Lys Asp Gln Asn Asn Ile Pro Ile Asn Asn Ser Lys Ala 
                645                 650                 655     


Asn Ser Thr Glu Tyr Arg Met Leu Gln Arg Ala Leu Ala Leu Phe Gly 
            660                 665                 670         


Ser Glu Asn Phe Arg Leu Lys Ala Tyr Phe Asn Gln Met Asn Leu Val 
        675                 680                 685             


Gly Asn Asp Asn Pro His Pro Phe Leu Ala Glu Thr Gln Trp Glu His 
    690                 695                 700                 


Gln Thr Asn Ile Leu Ser Phe Tyr Arg Asn Tyr Leu Glu Ala Arg Lys 
705                 710                 715                 720 


Lys Tyr Leu Lys Gly Leu Lys Pro Gln Asn Trp Lys Gln Tyr Gln His 
                725                 730                 735     


Phe Leu Ile Leu Lys Val Gln Lys Thr Asn Arg Asn Thr Leu Val Thr 
            740                 745                 750         


Gly Trp Lys Asn Ser Phe Asn Leu Pro Arg Gly Ile Phe Thr Gln Pro 
        755                 760                 765             


Ile Arg Glu Trp Phe Glu Lys His Asn Asn Ser Lys Arg Ile Tyr Asp 
    770                 775                 780                 


Gln Ile Leu Ser Phe Asp Arg Val Gly Phe Val Ala Lys Ala Ile Pro 
785                 790                 795                 800 


Leu Tyr Phe Ala Glu Glu Tyr Lys Asp Asn Val Gln Pro Phe Tyr Asp 
                805                 810                 815     


Tyr Pro Phe Asn Ile Gly Asn Lys Leu Lys Pro Gln Lys Gly Gln Phe 
            820                 825                 830         


Leu Asp Lys Lys Glu Arg Val Glu Leu Trp Gln Lys Asn Lys Glu Leu 
        835                 840                 845             


Phe Lys Asn Tyr Pro Ser Glu Lys Lys Lys Thr Asp Leu Ala Tyr Leu 
    850                 855                 860                 


Asp Phe Leu Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys 
865                 870                 875                 880 


Asn Gln Asp Ile Val Thr Trp Leu Met Phe Lys Glu Leu Phe Lys Thr 
                885                 890                 895     


Thr Thr Val Glu Gly Leu Lys Ile Gly Glu Ile His Leu Arg Asp Ile 
            900                 905                 910         


Asp Thr Asn Thr Ala Asn Glu Glu Ser Asn Asn Ile Leu Asn Arg Ile 
        915                 920                 925             


Met Pro Met Lys Leu Pro Val Lys Thr Tyr Glu Thr Asp Asn Lys Gly 
    930                 935                 940                 


Asn Ile Leu Lys Glu Arg Pro Leu Ala Thr Phe Tyr Ile Glu Glu Thr 
945                 950                 955                 960 


Glu Thr Lys Val Leu Lys Gln Gly Asn Phe Lys Val Leu Ala Lys Asp 
                965                 970                 975     


Arg Arg Leu Asn Gly Leu Leu Ser Phe Ala Glu Thr Thr Asp Ile Asp 
            980                 985                 990         


Leu Glu Lys Asn Pro Ile Thr Lys  Leu Ser Val Asp His  Glu Leu Ile 
        995                 1000                 1005             


Lys Tyr  Gln Thr Thr Arg Ile  Ser Ile Phe Glu Met  Thr Leu Gly 
    1010                 1015                 1020             


Leu Glu  Lys Lys Leu Ile Asp  Lys Tyr Ser Thr Leu  Pro Thr Asp 
    1025                 1030                 1035             


Ser Phe  Arg Asn Met Leu Glu  Arg Trp Leu Gln Cys  Lys Ala Asn 
    1040                 1045                 1050             


Arg Pro  Glu Leu Lys Asn Tyr  Val Asn Ser Leu Ile  Ala Val Arg 
    1055                 1060                 1065             


Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met Tyr Asp  Ala Thr Leu 
    1070                 1075                 1080             


Phe Ala  Glu Val Lys Lys Phe  Thr Leu Phe Pro Ser  Val Asp Thr 
    1085                 1090                 1095             


Lys Lys  Ile Glu Leu Asn Ile  Ala Pro Gln Leu Leu  Glu Ile Val 
    1100                 1105                 1110             


Gly Lys  Ala Ile Lys Glu Ile  Glu Lys Ser Glu Asn  Lys Asn 
    1115                 1120                 1125         


<210>  1821
<211>  1126
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1821

Met Glu Asp Asp Lys Lys Thr Thr Asp Ser Ile Ser Tyr Glu Leu Lys 
1               5                   10                  15      


Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val 
            20                  25                  30          


Tyr Ile Thr Val Asn His Ile Asn Lys Ile Leu Glu Glu Gly Glu Ile 
        35                  40                  45              


Asn Arg Asp Gly Tyr Glu Lys Thr Leu Glu Asn Ser Trp Asn Glu Ile 
    50                  55                  60                  


Lys Asp Ile Asn Lys Lys Asp Arg Leu Ser Lys Leu Ile Ile Lys His 
65                  70                  75                  80  


Phe Pro Phe Leu Glu Ala Thr Thr Tyr Arg Arg Asn Pro Thr Asp Thr 
                85                  90                  95      


Thr Lys Gln Lys Glu Glu Lys Gln Ala Glu Ala Gln Ser Leu Glu Asn 
            100                 105                 110         


Leu Lys Glu Ser Phe Phe Val Phe Ile Tyr Lys Leu Arg Asp Leu Arg 
        115                 120                 125             


Asn His Tyr Ser His Tyr Lys His Ser Lys Ser Leu Glu Arg Pro Lys 
    130                 135                 140                 


Phe Glu Glu Asn Leu Leu Lys Lys Met Tyr Asn Ile Phe Asn Ala Ser 
145                 150                 155                 160 


Ile Arg Leu Val Lys Glu Asp Tyr Gln Tyr Asn Lys Asn Ile Asn Pro 
                165                 170                 175     


Lys Lys Asp Phe Lys His Leu Asp Arg Lys Arg Lys Gly Lys Phe Tyr 
            180                 185                 190         


Tyr Ser Phe Ala Asp Asn Glu Gly Asn Ile Thr Glu Ser Gly Leu Leu 
        195                 200                 205             


Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Val Gln 
    210                 215                 220                 


Lys Lys Leu Glu Gly Phe Lys Cys Ser Asn Lys Ser Tyr Gln Lys Met 
225                 230                 235                 240 


Thr Asn Glu Val Phe Cys Arg Ser Arg Met Leu Leu Pro Lys Leu Arg 
                245                 250                 255     


Leu Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu Asn 
            260                 265                 270         


Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Gln Gly Glu 
        275                 280                 285             


Asp Arg Glu Lys Phe Arg Val Pro Leu Asp Pro Ile Asp Glu Asp Tyr 
    290                 295                 300                 


Asp Val Glu Gln Glu Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp 
305                 310                 315                 320 


Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Tyr Asn Glu Ile Phe 
                325                 330                 335     


Thr Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile 
            340                 345                 350         


Tyr Lys Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg His Leu Thr His 
        355                 360                 365             


Lys Leu Tyr Gly Phe Glu Arg Ile Gln Glu Phe Asp Lys Gln Asn Arg 
    370                 375                 380                 


Pro Asp Glu Trp Lys Ala Ile Val Lys Asp Ser Asp Thr Phe Lys Lys 
385                 390                 395                 400 


Lys Glu Glu Lys Glu Glu Glu Lys Pro Tyr Ile Ser Glu Thr Thr Pro 
                405                 410                 415     


His Tyr His Leu Glu Asn Lys Lys Ile Gly Ile Ala Phe Lys Asn His 
            420                 425                 430         


Asn Ile Trp Pro Ser Thr Gln Thr Glu Leu Thr Asn Asn Lys Arg Lys 
        435                 440                 445             


Lys Tyr Asn Leu Gly Thr Ser Ile Lys Ala Glu Ala Phe Leu Ser Val 
    450                 455                 460                 


His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Lys Thr Glu 
465                 470                 475                 480 


Asn Thr Lys Asn Asp Asn Lys Val Glu Gly Lys Lys Glu Thr Lys Lys 
                485                 490                 495     


Gln Gly Lys His Lys Ile Glu Ala Ile Ile Glu Ser Lys Ile Lys Asp 
            500                 505                 510         


Ile Tyr Ala Leu Tyr Asp Ala Phe Ala Asn Gly Glu Ile Asn Ser Glu 
        515                 520                 525             


Lys Glu Leu Glu Glu Tyr Leu Lys Gly Lys Asp Ile Glu Ile Val His 
    530                 535                 540                 


Leu Pro Lys Gln Met Ile Ala Ile Leu Lys Asn Glu His Lys Asp Met 
545                 550                 555                 560 


Ala Glu Lys Ala Glu Ala Lys Gln Glu Lys Met Lys Leu Ala Thr Glu 
                565                 570                 575     


Asn Arg Leu Lys Thr Leu Asp Lys Gln Leu Lys Gly Lys Ile Gln Asn 
            580                 585                 590         


Gly Lys Arg Tyr Asn Ser Ala Pro Lys Ser Gly Glu Ile Ala Ser Trp 
        595                 600                 605             


Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln Lys Asp Asn Glu 
    610                 615                 620                 


Gly Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln Leu 
625                 630                 635                 640 


Leu Gln Arg Thr Leu Ala Phe Phe Gly Ser Glu His Glu Arg Phe Ala 
                645                 650                 655     


Pro Tyr Phe Lys Gln Thr Lys Leu Ile Glu Ser Ser Asn Pro His Pro 
            660                 665                 670         


Phe Leu Lys Asp Thr Glu Trp Glu Lys Cys Asn Asn Ile Leu Ser Phe 
        675                 680                 685             


Tyr Arg Ser Tyr Leu Lys Ala Lys Lys Asn Phe Leu Glu Ser Leu Lys 
    690                 695                 700                 


Pro Glu Asp Trp Glu Lys Asn Gln Tyr Phe Leu Met Leu Lys Glu Pro 
705                 710                 715                 720 


Lys Thr Asn Arg Lys Thr Leu Val Gln Gly Trp Lys Asn Gly Phe Asn 
                725                 730                 735     


Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg Lys Trp Phe Met Glu 
            740                 745                 750         


His Trp Lys Asn Ile Lys Val Asp Asp Ser Lys Arg Val Gly Leu Val 
        755                 760                 765             


Ala Lys Val Ile Pro Leu Phe Phe Ser Glu Lys Tyr Lys Asp Ser Val 
    770                 775                 780                 


Gln Pro Phe Tyr Asn Tyr Pro Phe Asn Val Gly Asp Val Asn Lys Pro 
785                 790                 795                 800 


Lys Glu Glu Asp Phe Leu His Arg Lys Asp Arg Ile Glu Leu Trp Asp 
                805                 810                 815     


Lys Asn Lys Asp Lys Phe Lys Gly Tyr Lys Ala Lys Lys Lys Phe Lys 
            820                 825                 830         


Glu Met Thr Asp Lys Glu Lys Glu Glu His Arg Ser Tyr Leu Glu Phe 
        835                 840                 845             


Gln Ser Trp Asn Gln Phe Glu Arg Glu Leu Arg Leu Val Arg Asn Gln 
    850                 855                 860                 


Asp Ile Val Thr Trp Leu Leu Cys Thr Glu Leu Ile Asp Lys Leu Lys 
865                 870                 875                 880 


Val Glu Gly Leu Asn Val Glu Glu Leu Lys Lys Leu Arg Leu Lys Glu 
                885                 890                 895     


Ile Asn Thr Asp Thr Ala Lys Lys Asp Lys Asn Asn Ile Leu Asn Arg 
            900                 905                 910         


Val Met Pro Met Glu Leu Pro Val Thr Val Tyr Glu Val Asn Lys Ala 
        915                 920                 925             


Ser Asn Ile Ile Lys Asn Lys Pro Leu His Thr Ile Tyr Ile Lys Glu 
    930                 935                 940                 


Ala Lys Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys 
945                 950                 955                 960 


Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Val Asp Thr Ser Ser Lys 
                965                 970                 975     


Ala Glu Ser Glu Ser Asn Thr Ile Ser Lys Ser Arg Val Glu Tyr Glu 
            980                 985                 990         


Leu Gly Glu Tyr Gln Lys Ala Arg  Ile Glu Ile Ile Lys  Asp Met Leu 
        995                 1000                 1005             


Ala Leu  Glu Glu Thr Leu Ile  Asp Lys Tyr Asp Leu  Asn His Asp 
    1010                 1015                 1020             


Asn Phe  Asn Lys Met Leu Thr  Gly Trp Leu Glu Leu  Lys Asn Lys 
    1025                 1030                 1035             


Ala Asn  Lys Ala Ser Leu Glu  Lys Thr Asp Lys Thr  Ser Phe Gln 
    1040                 1045                 1050             


Asn Asp  Val Asp Leu Leu Ile  Ala Val Arg Asn Ala  Phe Ser His 
    1055                 1060                 1065             


Asn Gln  Tyr Pro Met Arg Asn  Arg Ile Ala Phe Ala  Asn Ile Asn 
    1070                 1075                 1080             


Pro Phe  Ser Leu Ser Ser Ala  Asn Thr Ser Glu Glu  Lys Gly Leu 
    1085                 1090                 1095             


Gly Ile  Ala Asn Gln Leu Lys  Asp Lys Thr Lys Glu  Thr Ile Glu 
    1100                 1105                 1110             


Lys Ile  Ile Lys Ile Glu Lys  Pro Ile Glu Thr Lys  Glu 
    1115                 1120                 1125     


<210>  1822
<211>  1119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1822

Met Thr Glu Gln Asn Glu Lys Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Ala His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Met Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Lys Tyr Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Gly Thr Val Ala Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Ala Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Phe Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Asn Tyr Ser Asp Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Asp Glu Ile Asn Thr Arg Asp 
    530                 535                 540                 


Glu Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Thr Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Ile Arg Lys Lys Leu Gln Glu Met Met Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asn Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu Arg Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Gly Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Tyr Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Leu Ala Lys Leu Lys Lys Glu Ile Leu Glu Ala 
        835                 840                 845             


Lys Glu His Pro Tyr His Asp Phe Lys Ser Trp Gln Lys Phe Glu Arg 
    850                 855                 860                 


Glu Leu Arg Leu Val Lys Asn Gln Asp Ile Ile Thr Trp Met Met Cys 
865                 870                 875                 880 


Arg Asp Leu Met Glu Glu Asn Lys Val Glu Gly Leu Asp Thr Gly Thr 
                885                 890                 895     


Leu Tyr Leu Lys Asp Ile Arg Thr Asp Val Gln Glu Gln Gly Ser Leu 
            900                 905                 910         


Asn Val Leu Asn Arg Val Lys Pro Met Arg Leu Pro Val Val Val Tyr 
        915                 920                 925             


Arg Ala Asp Ser Arg Gly His Val His Lys Glu Glu Ala Pro Leu Ala 
    930                 935                 940                 


Thr Val Tyr Ile Glu Glu Arg Asp Thr Lys Leu Leu Lys Gln Gly Asn 
945                 950                 955                 960 


Phe Lys Ser Phe Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe 
                965                 970                 975     


Val Asp Thr Gly Gly Leu Ala Met Glu Gln Tyr Pro Ile Ser Lys Leu 
            980                 985                 990         


Arg Val Glu Tyr Glu Leu Ala Lys  Tyr Gln Thr Ala Arg  Val Cys Ala 
        995                 1000                 1005             


Phe Glu  Gln Thr Leu Glu Leu  Glu Glu Ser Leu Leu  Thr Arg Tyr 
    1010                 1015                 1020             


Pro His  Leu Pro Asp Lys Asn  Phe Arg Lys Met Leu  Glu Ser Trp 
    1025                 1030                 1035             


Ser Asp  Pro Leu Leu Asp Lys  Trp Pro Asp Leu His  Arg Lys Val 
    1040                 1045                 1050             


Arg Leu  Leu Ile Ala Val Arg  Asn Ala Phe Ser His  Asn Gln Tyr 
    1055                 1060                 1065             


Pro Met  Tyr Asp Glu Ala Val  Phe Ser Ser Ile Arg  Lys Tyr Asp 
    1070                 1075                 1080             


Pro Ser  Ser Pro Asp Ala Ile  Glu Glu Arg Met Gly  Leu Asn Ile 
    1085                 1090                 1095             


Ala His  Arg Leu Ser Glu Glu  Val Lys Gln Ala Lys  Glu Met Val 
    1100                 1105                 1110             


Glu Arg  Ile Ile Gln Val 
    1115                 


<210>  1823
<211>  1085
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1823

Met Lys Lys Glu Leu Asn Arg Glu Asp Val Phe Thr Gly Gly Lys Thr 
1               5                   10                  15      


Pro Glu Leu Thr Ile Tyr Tyr Asn Ile Ala Tyr Phe Arg Met Ala Gly 
            20                  25                  30          


Leu Ile Asn Ala Leu Cys Gly Asn Lys Leu Glu Arg Asp Lys Asp Ala 
        35                  40                  45              


Leu Glu Gln Phe Met Lys Ala Phe Ile Asn Gly Lys Gln Lys Leu Thr 
    50                  55                  60                  


Asp Met Gln Phe Val Lys Leu Cys Asp Tyr Leu Trp Lys Gly Tyr Lys 
65                  70                  75                  80  


Tyr Asp Lys Asn Arg Ser Glu Tyr Ser Leu Thr Glu Asn Asp Lys Thr 
                85                  90                  95      


Met Val Leu Lys Met Val Ala Lys Leu Gln Asp Ile Arg Asn Phe Gln 
            100                 105                 110         


Ser His Ile Trp His Asp Asn Lys Val Leu Val Phe Asp Ala Asp Leu 
        115                 120                 125             


Val Gln Phe Ile Lys Asn Lys His Leu Glu Ala Ile Asp Ala Gln Arg 
    130                 135                 140                 


Gln Arg Phe Ser Lys Glu Thr Glu Val Tyr Glu Lys Glu Asn Arg Glu 
145                 150                 155                 160 


Leu Lys Lys Lys Lys Asn Lys Glu Leu Leu Phe Asp Ile His Asp Gly 
                165                 170                 175     


Leu Gly Tyr Ile Thr Gly Glu Gly Arg Asn Phe Phe Leu Ser Phe Phe 
            180                 185                 190         


Leu Thr Arg Gly Glu Met Thr Arg Phe Leu Lys Gln Arg Lys Gly Cys 
        195                 200                 205             


Lys Arg Asp Asp Thr Pro Glu Tyr Lys Ile Lys His Leu Val Tyr Arg 
    210                 215                 220                 


His Phe Thr His Arg Asp Gly Ala Thr Arg Thr His Tyr Gly Tyr Glu 
225                 230                 235                 240 


Asp Asn Met Leu Asp Gln Leu Pro Asp Lys Gln Glu Phe Leu Thr Thr 
                245                 250                 255     


Arg His Thr Tyr Arg Leu Ile Asn Tyr Leu Asn Asp Ile Pro Glu Glu 
            260                 265                 270         


Val Thr Asn Pro Glu Leu Phe Pro Leu Phe Asn Thr Ile Ser Asn Gly 
        275                 280                 285             


Ile Leu Ile Lys Glu Ser Val Gly Thr Tyr Ile Ala Phe Ile Asn Lys 
    290                 295                 300                 


Met Pro Leu Leu Ser Asp Phe Glu Phe Ser Glu Val Trp Gly Lys Asp 
305                 310                 315                 320 


Gly Lys Pro Tyr Thr Asn Leu Val Glu Phe Tyr His Lys Thr Gln Pro 
                325                 330                 335     


Gly Phe Lys Phe Arg Thr Asp Leu Asn Ser Phe His Lys Ile Ile Leu 
            340                 345                 350         


Asn Leu Ile Arg Asp Glu Asn Tyr Thr Gly Phe Phe Thr Thr Gln Leu 
        355                 360                 365             


Asn Leu Phe Met Ala His Arg Glu Glu Leu Ile Leu Val Ile Ser Lys 
    370                 375                 380                 


Pro Leu Ile Thr Pro Asn Asp Leu Leu Leu Ile Glu Glu His Tyr Arg 
385                 390                 395                 400 


Tyr Lys Leu Lys Ala Asn Asp Phe Val Arg Glu Lys Leu Gly Glu Trp 
                405                 410                 415     


Lys Glu Lys Ile Glu Lys Gly Lys Trp Glu Lys Ala Asn Glu Gln Lys 
            420                 425                 430         


Asp Lys Leu Ile Asn Leu Leu Gly Gly Val Ile Glu Ile Thr Phe Tyr 
        435                 440                 445             


Asp Phe Tyr Trp Gln Lys Asp Glu Lys Pro Arg Asn Glu Asn Arg Phe 
    450                 455                 460                 


Met Glu Phe Ala Ile Arg Phe Met Ala Asp Phe Asn Leu Leu Pro Asp 
465                 470                 475                 480 


Cys Glu Trp Glu Val Glu Pro Leu Gln Ile Glu Asn Asp Leu Ile Ala 
                485                 490                 495     


Asn Arg Thr Ala Thr Pro Asp Leu Lys Lys Ser Gly Ser Gln Phe Met 
            500                 505                 510         


Asn Gln Leu Thr Asp Asn Tyr Arg Leu Lys Phe Asn Asp Gly Gln Ile 
        515                 520                 525             


Ala Phe Arg Tyr Gln Asn Gln Val Phe Ile Met Gly His Lys Ala Val 
    530                 535                 540                 


Lys Asn Leu Leu Ile Ala Cys Phe Asp Gly Lys Glu Lys Met Leu Asn 
545                 550                 555                 560 


Gly Phe Met Pro Ala Leu Leu Ala Asp Leu Lys Lys Ile Thr Asn Glu 
                565                 570                 575     


His Ile Leu Lys Asn His Gln Ala Leu Asn Thr Leu Ser Leu Leu Asn 
            580                 585                 590         


Asn Asp Ser Ile Pro Ser Tyr Ile Ser Arg Gln Trp Gly Glu Ala Glu 
        595                 600                 605             


Pro Ile Thr Asp Met Lys Lys Lys Ala Ile Ala Arg Met Asp Tyr Ile 
    610                 615                 620                 


Thr Gln Gln Phe Glu Ala Leu Ile Glu Asn His His Tyr Leu Asn Arg 
625                 630                 635                 640 


Ala Asp Lys Asn Arg Gln Ile Met Arg Cys Tyr Lys Phe Phe Glu Trp 
                645                 650                 655     


Gln Tyr Pro Gln Asn Ser Gln Phe Lys Phe Leu Arg Arg Asn Glu Tyr 
            660                 665                 670         


His Arg Met Ser Ile Tyr His Tyr Cys Leu Asp Lys Glu Gln His Lys 
        675                 680                 685             


Tyr Asp Lys Lys Gly His Asn Tyr Leu Tyr Asn Arg Leu Ile Lys Glu 
    690                 695                 700                 


Ser His Asn Glu Ser Gly Asn Ile Glu Gln His Leu Pro Tyr Gln Ile 
705                 710                 715                 720 


Arg Thr Met Leu Asn Asp Ala Lys Asp Phe Asn Asp Tyr Phe Leu Arg 
                725                 730                 735     


Ile Leu Asn Ala Thr His Lys Ile Leu Thr Asp Trp Lys Asn Gln Leu 
            740                 745                 750         


Lys Gln Gly Arg Glu Pro Asn Asn Tyr Tyr Leu Ser Arg Leu Gly Phe 
        755                 760                 765             


Thr Gly Gly Leu Thr Gln Lys Val Val His Thr Arg Leu Leu Pro Phe 
    770                 775                 780                 


Ser Ile His Pro Gly Ile Pro Val Ser Phe Phe Tyr Arg Thr Glu Met 
785                 790                 795                 800 


Asn Gln Asn Pro Ser Phe Asn Leu Ser Ala Lys Val Trp Asn Ser Glu 
                805                 810                 815     


Ser Pro Phe Arg Val Gly Leu Lys Glu Ser Asn Tyr Gln Tyr Ala Lys 
            820                 825                 830         


Tyr Leu Gly Leu Phe Asn Glu Ile Lys Thr Gln Arg Lys Ile Ile Gly 
        835                 840                 845             


Lys Met Asn Gln Leu Ile Ala Glu Asp Ala Leu Leu Trp Gln Ile Ala 
    850                 855                 860                 


Lys Lys Tyr Leu Asp Lys Cys His Pro Lys Phe Ser Glu Ile Ile Asn 
865                 870                 875                 880 


Gln Gln Val Asn Gly Lys Gln Pro Leu Asn Val Lys Ala Ile His Asp 
                885                 890                 895     


Thr Glu Leu Thr Ile Asp Phe Pro Val Asp Lys Asn Leu Tyr Gln Val 
            900                 905                 910         


Val Val Lys Met Lys Gln Leu Asp Asp Phe Met Phe Ile Asp Ser Lys 
        915                 920                 925             


Pro Val Leu Glu Lys Thr Ile Arg Tyr Met Ile Lys Asn Ser Leu Arg 
    930                 935                 940                 


Asp Lys Glu Tyr Gln Gln Arg Val Phe Ile Glu Thr Asn Pro Gly Val 
945                 950                 955                 960 


Phe Lys Ile Pro Tyr Asn Glu Val Val Glu Ala Met Arg Thr Ile Asn 
                965                 970                 975     


His Gln Ala Leu Thr Trp Ala Arg Leu Leu Leu Asp Trp Glu Ser Lys 
            980                 985                 990         


Thr Val Lys Thr Ile Pro Glu Ala  Asp Lys Lys Ala Lys  Leu Gln Glu 
        995                 1000                 1005             


Ala Tyr  Asn Lys Arg Gln Pro  Ala Phe Phe Asn Phe  Asn Asp Ile 
    1010                 1015                 1020             


Cys Arg  Tyr Ala Asp Asp Gly  Lys Gln Leu Lys Asp  Leu Arg Asn 
    1025                 1030                 1035             


Lys Thr  Phe His Thr Glu Val  Pro Glu Thr Trp Thr  Tyr Asp Glu 
    1040                 1045                 1050             


Met Arg  Glu Asn Lys Thr Ile  Lys Met Val Leu Gly  Ile Asn Glu 
    1055                 1060                 1065             


Thr Thr  Phe Leu Lys Lys Asp  Tyr Ala Ile Glu Asn  Ala Arg Thr 
    1070                 1075                 1080             


Ile Glu  
    1085 


<210>  1824
<211>  1164
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1824

Met Thr Ala Thr Asn Gly Leu Gly Lys Gly Ile Ser Tyr His His His 
1               5                   10                  15      


Leu Tyr Ala Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Asp 
            20                  25                  30          


Asp Asn Ile Asp Gln Val Lys Gln Leu Phe Asp Thr Arg Phe Gly Glu 
        35                  40                  45              


Lys Asn Ala Asp Arg Phe Phe Ser Thr Lys Asn Asn His Leu Ile Ala 
    50                  55                  60                  


Tyr Asp Asp Trp Glu Lys Gly Ile Asp Phe Leu Lys Gln Tyr Leu Pro 
65                  70                  75                  80  


Val Val His Tyr Leu Ala Leu Pro Val Asn His Glu Lys Phe Ser Asn 
                85                  90                  95      


Leu Thr Asp Lys Glu Lys Gly Arg Arg Asp Tyr Phe Thr Ile His Phe 
            100                 105                 110         


Asn Leu Leu Thr Ser Thr Ile His Asp Cys Arg Asn Phe Tyr Thr His 
        115                 120                 125             


Tyr Tyr His Asp Pro Ile Thr Val Gln Asn Asp Leu Phe Gln Leu Leu 
    130                 135                 140                 


Asp Glu Leu Phe Ile Leu Val Cys Arg Asp Val Arg Lys His Arg Ile 
145                 150                 155                 160 


Lys Thr Asp Lys Thr Gly Trp Leu Leu Lys Arg Thr Leu Gln Asn Glu 
                165                 170                 175     


Leu Gln Ile Leu Thr Lys His Lys Lys His Thr Leu Glu Lys Gln Lys 
            180                 185                 190         


Lys Glu Gly Lys Lys Val Asn Leu Asp Ala Glu Ala Ile Glu Asn Ala 
        195                 200                 205             


Val Met Asn Asp Ala Phe Lys His Leu Arg Tyr Thr Asp Lys Glu Asp 
    210                 215                 220                 


Asn Lys Gly Asn Ile Lys Lys Phe Leu Val Lys Asp Gln Tyr Lys Ser 
225                 230                 235                 240 


Ala Tyr Asn Arg Gln Glu Pro Ser Glu Asn Gly Ile Cys Leu Ser Arg 
                245                 250                 255     


Ser Gly Leu Leu Phe Leu Cys Ser Met Phe Leu Ser Arg Lys Ala Gly 
            260                 265                 270         


Glu Asp Met Arg Ala Arg Val Ser Gly Phe Lys Glu Lys Phe Val Tyr 
        275                 280                 285             


Arg Thr Glu Glu Glu Ile Thr Asp Lys Asn Asn Ser Leu Arg Ser Met 
    290                 295                 300                 


Val Thr Gln Trp Val Phe Ser His Leu Ala Phe Lys Asp Ile Lys Gln 
305                 310                 315                 320 


Arg Ile Thr Thr Asn Leu Asp Arg Glu Thr Leu Phe Val Gln Ile Val 
                325                 330                 335     


Asp Tyr Leu Ser Lys Val Pro Asp Glu Leu Tyr Gln Val Phe Ser Asn 
            340                 345                 350         


Thr Gln Lys Leu Asp Phe Leu Glu Asp Ile Asn Glu Tyr Ile Lys Glu 
        355                 360                 365             


Gly Asn Lys Thr Glu Ser Leu Ile Gln Ser Thr Val Ala His Pro Val 
    370                 375                 380                 


Ile Arg Lys Arg Tyr Glu Asn Gln Phe Asn Tyr Phe Val Leu Arg Tyr 
385                 390                 395                 400 


Leu Asp Glu Phe Val Glu Phe Pro Ser Leu Arg Phe Gln Ile Asn Thr 
                405                 410                 415     


Gly Phe Tyr Thr His Asp Gln Arg Glu Lys Thr Ile Glu Gly Thr Glu 
            420                 425                 430         


Tyr Leu Thr Asp Arg Lys Ile Lys Glu Lys Ile Lys Val Phe Gly Lys 
        435                 440                 445             


Leu Ser Glu Val Thr Thr Gln Lys Asn Glu Phe Leu Val Lys Asn Thr 
    450                 455                 460                 


Asp Leu Gln Gly Trp Glu Ala Tyr Pro Gly Pro Ser Tyr Asn Val Asn 
465                 470                 475                 480 


Asn Asn Asn Ile Pro Val Phe Ile Asn Met Gln Asn Asn Ala Val Asn 
                485                 490                 495     


Gly Ser Lys Gln Trp Tyr Ser Lys Ile Asn Phe Lys Ile Arg Asn Glu 
            500                 505                 510         


Arg Asn Leu Lys Gln Ser Pro Arg Thr Glu Asp Lys Lys Gln Lys Ser 
        515                 520                 525             


Ala Ile Ala Asp Met Leu Lys Ile Asn Gly Glu Met Asp Leu Arg Tyr 
    530                 535                 540                 


Glu Glu Pro Thr Ala Ile Leu Cys Leu Lys Glu Leu Pro Ser Leu Leu 
545                 550                 555                 560 


Tyr Glu Leu Leu Tyr Thr Lys Ala Ser Pro Lys Glu Ile Glu Glu His 
                565                 570                 575     


Leu Leu Lys Lys Ile Ile Gly His Leu Asp Thr Ile Glu Lys Tyr Ala 
            580                 585                 590         


His His Thr Asp Ser Ser Leu Gln Gly Met Pro Arg Lys Leu Lys Lys 
        595                 600                 605             


Ser Gly Glu Glu Ser Ser Ile Asn Tyr Lys Lys Leu Arg Glu Val Ile 
    610                 615                 620                 


Val Asn Glu Leu Lys Val Ile Thr Glu Lys Gln Asp Phe Leu Lys Glu 
625                 630                 635                 640 


Lys Gln Lys Asp Lys Lys Val Asn Lys Arg Leu Tyr Leu Leu Asn Asn 
                645                 650                 655     


Arg Glu Met Gly Lys Glu Ala Thr Trp Leu Ala Ser Asp Leu Ile Arg 
            660                 665                 670         


Phe Met Pro Glu Thr Ala Arg Lys Gln Trp Lys Gly Tyr His His Ser 
        675                 680                 685             


Gln Leu Gln Gln Thr Leu Ala Phe Tyr Gln Gln Lys Arg Lys Glu Ala 
    690                 695                 700                 


Leu Ser Leu Ile Gly Gln Phe Trp Asp Phe Asn Thr Gly Pro Tyr Trp 
705                 710                 715                 720 


Gly Asp Lys Leu Lys Lys Ala Phe Glu Gln Thr Thr Phe Glu Asp Phe 
                725                 730                 735     


Tyr Phe Glu Tyr Leu Lys Met Arg Gln Ala Ile Leu Asn Asn Phe Leu 
            740                 745                 750         


Glu Asn Val Ser Ser Ser Gln Asn Gln Pro Asn Leu Ala Lys Lys Ala 
        755                 760                 765             


Leu Lys Asp Cys Trp Ile Ile Phe His Lys Arg His Phe Ile Ile Arg 
    770                 775                 780                 


Pro Ala Lys Glu Gln Ile Ser Ser Leu Leu Ala Gln Pro Val Val Leu 
785                 790                 795                 800 


Pro Arg Gly Leu Phe Asp Asn Lys Pro Thr Tyr Ile Lys Asp Val Lys 
                805                 810                 815     


Leu Glu Asp Ala Pro Glu Lys Phe Ala Asn Trp Tyr Arg Tyr Thr Tyr 
            820                 825                 830         


Asn Asp Tyr Pro Met Gln Arg Phe Tyr Ser Phe Asp Arg Asp Tyr Thr 
        835                 840                 845             


Ser Leu Tyr Glu Glu Phe Gln Ser Asn Lys Asp Val Ile Leu Asn Lys 
    850                 855                 860                 


Lys Arg Leu Thr Lys Ser Glu Gln Glu Ala Leu Leu Lys Lys Lys Gln 
865                 870                 875                 880 


Asp Leu Lys Ile Lys Asp Ile Arg Thr Gln Asp Leu Phe Leu Lys Leu 
                885                 890                 895     


Ile Ala Asp Lys Leu Phe Glu Asp Ile Phe Asp Gln Lys Ala Asp Phe 
            900                 905                 910         


Thr Leu Glu Asp Ile Tyr Gln Thr Arg Glu Glu Arg Met Gln Asn Gly 
        915                 920                 925             


Glu Gln Ala Leu Gln Gln Ser Glu Arg Ala Pro Gly Asp Asp Phe Glu 
    930                 935                 940                 


Asn Ile Tyr Asn Glu Ser Phe Val Leu Asn Lys Thr Val Pro Phe Ile 
945                 950                 955                 960 


Gln Lys Gln Ile His Glu Pro Thr Val Lys Ile Lys Asp Leu Gly Lys 
                965                 970                 975     


Phe Lys Arg Phe Leu Phe Asp Asn Lys Val Lys Ala Leu Phe Ser Tyr 
            980                 985                 990         


Glu Pro Asn Arg Val Trp Ser Ile  Gln Glu Leu Glu Asn  Glu Leu Thr 
        995                 1000                 1005             


Leu Leu  Pro Thr Ser Tyr Glu  Val Ile Arg Arg Val  Ser Leu Leu 
    1010                 1015                 1020             


Lys Ala  Ile Gln Glu Phe Glu  Lys Tyr Ile Met Glu  Cys Trp Gly 
    1025                 1030                 1035             


Asp Ser  Asp Thr Thr Lys Leu  Asp Gln Lys Asp Lys  Lys Ser Gly 
    1040                 1045                 1050             


Lys Tyr  Asn Pro Ser Phe Lys  Lys Tyr Ile Phe Asn  Gly Val Leu 
    1055                 1060                 1065             


Asp Lys  Phe Arg Leu Ala Asn  Ala Glu Asn Ile Lys  His Ile Ile 
    1070                 1075                 1080             


Asp Tyr  Lys Lys Phe Glu Glu  Leu Val Asp Asp Pro  Gln Leu Lys 
    1085                 1090                 1095             


Ser Phe  Glu Glu Ile Val Arg  Lys Ala Tyr Ile Leu  Thr Ile Ile 
    1100                 1105                 1110             


Arg Asn  Lys Ile Ala His Asn  Gln Leu Pro Asp Lys  Ala Asn Met 
    1115                 1120                 1125             


Asp Phe  Ile Gln Gly Met Tyr  Pro Lys Glu Pro Gln  Asp Ser Tyr 
    1130                 1135                 1140             


Ser Gln  Tyr Leu Leu Arg Val  Thr Gln Leu Ile Ile  Asp Glu Met 
    1145                 1150                 1155             


Val Leu  Leu Met Lys Ile 
    1160                 


<210>  1825
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1825

Met Glu Thr Lys Gln Gln Val Gly Lys Gly Ile Ser Tyr Asp His Arg 
1               5                   10                  15      


Arg Pro Asp Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asp Gly Val Ile Gln Glu Phe Ala Met Arg Leu Asn Arg 
        35                  40                  45              


Glu Tyr Asp Pro Glu Asn Lys Asn Gln Ser Leu Phe Ser Tyr Phe Asn 
    50                  55                  60                  


Ile Asn Ala Ser Phe Thr Asp Trp Glu Arg Gly Val Asn Ile Leu Lys 
65                  70                  75                  80  


Glu Tyr Trp Pro Met Met Glu Phe Ile Asp Arg Pro Ala Thr Asp Lys 
                85                  90                  95      


Gln Phe Glu Ala Glu Lys Pro Glu Asn Arg Glu Ala Ala Lys Arg Lys 
            100                 105                 110         


Tyr Phe Leu Ala Thr Leu Gly Ala Leu Leu Thr Ser Ile Lys Asp Leu 
        115                 120                 125             


Arg His Tyr Tyr Thr His Tyr Tyr His Pro Pro Val His Leu Asn Asp 
    130                 135                 140                 


Asp Leu Phe Leu Phe Leu Asp His Ala Leu Leu Tyr Thr Ala Phe Asp 
145                 150                 155                 160 


Val Lys Lys Thr Lys Met Lys Asp Asp Lys Thr Arg Gln Leu Leu Asn 
                165                 170                 175     


Gln Asn Leu Ser Leu Glu Leu Glu Lys Leu Lys Lys Leu Lys Val Glu 
            180                 185                 190         


Glu Leu Lys Lys Lys Lys Glu Lys Gly Ile Lys Val Asn Leu Gln Asp 
        195                 200                 205             


Glu Lys Gly Ile Leu Asn Ala Ile Tyr Asn Asp Ala Phe Ala His Ile 
    210                 215                 220                 


Ile Thr Lys Glu Lys Asp Ser Asp Lys Asp Lys Leu Glu Thr Arg Tyr 
225                 230                 235                 240 


Lys Ser Ile Leu Pro Gln Asp Glu Ala Ala Glu Thr Gly Ile Asn Ile 
                245                 250                 255     


Ser Ile Ser Gly Leu Ile Phe Leu Leu Ser Leu Phe Leu Ser Arg Lys 
            260                 265                 270         


Glu Ile Glu Gln Leu Lys Ser Asn Ile Glu Gly Tyr Lys Gly Lys Val 
        275                 280                 285             


Leu Asn Ile Glu Thr Glu Val Asp Arg Lys His Asn Ser Leu Lys Tyr 
    290                 295                 300                 


Met Ala Thr His Trp Val Phe Ser Ile Leu Ala Phe Lys Gly Leu Lys 
305                 310                 315                 320 


Gln Arg Leu Thr Asn Ser Phe Glu Lys Glu Ser Leu Leu Ile Gln Met 
                325                 330                 335     


Met Asp Glu Leu Asn Lys Val Pro Asp Glu Leu Tyr Gln Thr Leu Ser 
            340                 345                 350         


Glu Thr Ala Lys Lys Glu Phe Leu Glu Asp Ile Asn Glu Tyr Val Ser 
        355                 360                 365             


Glu Gly Asp Asp Asn Glu Lys Ala Thr Tyr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Ser Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gln Phe Pro Thr Leu Lys Phe Gln Ile Phe Val Gly 
                405                 410                 415     


Gln Tyr Leu His Asp Asn Arg Pro Lys Thr Leu Ala Ser Asn Gly Met 
            420                 425                 430         


Thr Ala Gln Arg Met Ile Lys Glu Lys Ile Asn Leu Phe Gly Asn Leu 
        435                 440                 445             


Ser Glu Val Thr Lys His Lys Ser Asp Phe Phe Glu Lys Glu Ser Ala 
    450                 455                 460                 


Ala Gln Gly Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Trp Ala Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Val Tyr Ile Asp Met Ile Gly Lys Glu Gly Lys Ala 
                485                 490                 495     


Lys Glu Ile Gln Val Gln Ile Asn Lys Tyr Arg Lys Gln Leu Asn Pro 
            500                 505                 510         


Ala Pro Gln Arg Asp Lys Arg Ile Ser Lys Lys Glu Ile Ile Glu Gln 
        515                 520                 525             


Leu Tyr Lys Glu Lys Val Val Tyr Gly Asp Pro Thr Leu Met Leu Ser 
    530                 535                 540                 


Ala Asn Glu Leu Met Ala Leu Leu Tyr Glu Leu Ile Val Asn Gly Lys 
545                 550                 555                 560 


Ser Gly Ala Glu Leu Glu Asn Lys Ile Val Glu Gln Ile Ile Ala Arg 
                565                 570                 575     


Tyr Glu Gln Ile Glu Ala Tyr Asp Pro Thr Thr Gln Gln Leu Pro Thr 
            580                 585                 590         


Asn Gln Met Pro His Lys Leu Gln Lys Ser Arg Lys Asp Ser Lys Val 
        595                 600                 605             


Thr Asp Thr Asp Lys Leu Leu Lys Thr Ile Asp Lys Glu Ile Asp Glu 
    610                 615                 620                 


Gly Asn Lys Lys Leu Glu Leu Ile Ala Cys His Arg Lys Glu Trp Glu 
625                 630                 635                 640 


Glu Ala Glu Gln Arg Lys Lys Ser Gly Lys Arg Asn Asn Pro Gly Thr 
                645                 650                 655     


Lys Ser Arg Lys His Leu Phe Tyr Ala Ser Glu Met Gly Glu Glu Ala 
            660                 665                 670         


Thr Trp Ile Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Pro Ala Arg 
        675                 680                 685             


Ala Glu Trp Lys Gly Thr His His Ser Glu Leu Gln Arg Leu Leu Ala 
    690                 695                 700                 


Phe Tyr Ser Thr Gln Arg Leu Glu Ala Trp Gln Leu Val Glu Ser Val 
705                 710                 715                 720 


Trp Thr Ala Asn Thr His Ser Phe Trp Glu Glu Asn Phe Lys Glu Ala 
                725                 730                 735     


Phe Tyr Lys Pro Glu Phe Glu Asn Phe Tyr Gly Ala Tyr Ile Glu Ile 
            740                 745                 750         


Arg Thr Lys Ile Leu Thr Thr Cys Arg Ser Ile Leu Glu Asn Asn Pro 
        755                 760                 765             


Glu Ala Thr Met Asn Asn Asp Thr Glu Lys Glu Trp Asp Lys Val Phe 
    770                 775                 780                 


Thr Leu Phe Asp Lys Arg Leu Tyr Arg Thr Ser Thr Thr Asp Glu Gln 
785                 790                 795                 800 


Lys Lys Gln Leu Leu Thr Lys Pro Phe Ala Phe Pro Arg Gly Leu Phe 
                805                 810                 815     


Asp Asp Lys Pro Thr Phe Leu Pro Gly Ser Lys Pro Asn Glu Asn Pro 
            820                 825                 830         


Glu Arg Phe Ala Ala Trp Tyr Ser Tyr Gly Tyr Thr Tyr Ser Gly Lys 
        835                 840                 845             


Phe Gln Ser Phe Tyr Asp Met Pro Arg Asn Tyr Ser Asp Trp Tyr Lys 
    850                 855                 860                 


Lys Leu Lys Glu Asp Gly Lys Leu Pro Arg Leu Asp Lys Lys Thr Glu 
865                 870                 875                 880 


Gln Glu Lys Ile Leu Arg Phe Arg Met Asp Cys Asp Leu Asn Ile Lys 
                885                 890                 895     


His Ile Arg Phe Gln Asp Ile Tyr Val Lys Leu Met Val Asp Ser Leu 
            900                 905                 910         


Tyr Lys Ala Val Phe Gly Gln Gln Pro Glu Phe Asp Leu Ser His Leu 
        915                 920                 925             


Tyr Asp Thr Arg Ser Glu Arg Tyr Glu Asn Asn Thr Ile Ala Gln Arg 
    930                 935                 940                 


Gln Lys Ser Arg Gln Glu Gly Asp Asn Ser Asp Asn Ala Ile Asn Glu 
945                 950                 955                 960 


Asn Tyr Val Trp Asn Lys Thr Phe Ala Ile Ser Leu Tyr Asn Gly Arg 
                965                 970                 975     


Ile Thr Glu Ser Gln Val Lys Leu Lys Asp Val Gly Lys Phe Arg Arg 
            980                 985                 990         


Phe Ala Thr Asp Pro Arg Val Gln  Thr Leu Ile Ser Tyr  Asp Asp Thr 
        995                 1000                 1005             


Arg Thr  Trp Thr Lys Leu Glu  Ile Glu Asn Glu Leu  Asp Asn Lys 
    1010                 1015                 1020             


Ala Asp  Ala Tyr Glu Pro Ile  Arg Arg Thr Gln Ser  Leu Lys Ala 
    1025                 1030                 1035             


Ile Gln  Gln Leu Glu Lys Asn  Ile Leu Lys Lys Asn  Gly Phe Asn 
    1040                 1045                 1050             


Gly Lys  Gln His Pro Glu Glu  Leu Lys His Asn Gly  Asn Pro Asn 
    1055                 1060                 1065             


Phe Arg  Lys Tyr Ile Ala Asn  Gly Leu Leu Lys His  Arg Thr Asp 
    1070                 1075                 1080             


Ile Arg  Gln Glu Glu Leu Ala  Leu Ile Ser Asp Thr  Glu Phe Gln 
    1085                 1090                 1095             


Glu Ile  Gly Leu Glu Arg Ile  Arg Gln Thr Asn Pro  Leu Ile Gln 
    1100                 1105                 1110             


Lys Ala  Tyr Leu Leu Ile Leu  Leu Arg Asn Lys Phe  Gly His Asn 
    1115                 1120                 1125             


Gln Leu  Pro Asp Gln Glu His  Phe Arg Leu Met Arg  Ser Ile Tyr 
    1130                 1135                 1140             


Pro Tyr  Asn Gln Gln Glu Ser  Tyr Ser Ala Tyr Phe  Asn His Val 
    1145                 1150                 1155             


Ile Thr  Gln Ile Ile Glu Glu  Leu Asn Thr 
    1160                 1165             


<210>  1826
<211>  1126
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1826

Leu Arg Leu Phe Ile Arg Ser Ile Ile Leu Phe Ser Ile Thr Cys Phe 
1               5                   10                  15      


Lys Thr Val Asn Lys Asn Leu Ser Phe Leu Leu Phe Arg Leu Thr Ile 
            20                  25                  30          


Phe Leu Tyr Leu Leu Phe Pro Lys Asn Arg Cys Leu Ala Ser Ile Asn 
        35                  40                  45              


Leu Lys Pro Asn Lys Tyr Thr Thr Met Glu Glu Lys Tyr Tyr Gly Gln 
    50                  55                  60                  


Gly Val Ser Tyr Thr Leu Asn His Lys His Tyr Phe Ala Leu Tyr Leu 
65                  70                  75                  80  


Asn Leu Ala Gln Asn Asn Leu Asn Lys Ile Leu Gly Glu Phe Glu Lys 
                85                  90                  95      


Ile Tyr Pro Arg Leu His His Asp Tyr Leu Pro Asn Gln Pro Gly Ala 
            100                 105                 110         


Leu Val Gln Lys Leu His Gln Leu Leu Pro Leu Thr Glu Glu Asp Ala 
        115                 120                 125             


Val Glu Thr Arg Gly Arg Leu Asn Tyr Leu Ser Arg Ser Leu Pro Phe 
    130                 135                 140                 


Val Asn Ala Ile Leu Lys Gln Gly Glu Tyr Thr Ala Tyr Arg Glu Glu 
145                 150                 155                 160 


Leu Ile His Phe Phe Thr Arg Met Asn Gln Leu Arg Asn Tyr Phe Thr 
                165                 170                 175     


His Asp Leu Tyr Gln Ile Asp Glu Leu Glu Phe Gly Arg Asn Glu Lys 
            180                 185                 190         


Leu Phe Arg Phe Leu Asn Glu Ile Lys Lys Leu Val Leu Tyr Arg Leu 
        195                 200                 205             


Asn Lys Glu Pro Tyr Phe Ile Gly Ser Glu Asn Leu Thr His Leu Ala 
    210                 215                 220                 


Glu Pro Asn Gly Tyr Phe Asn Phe Leu Ala Glu Gln Asn Lys Lys Ala 
225                 230                 235                 240 


Ala Ile Asn Phe Leu Val Cys Leu Phe Leu Glu Arg Lys Thr Ala Met 
                245                 250                 255     


Glu Phe Leu Lys Val Gln Arg Gly Tyr Lys Ser Ser Asn Asn Pro Ala 
            260                 265                 270         


His Lys Ala Thr Leu Ser Ser Phe Thr His Phe Ser Val Lys Met Pro 
        275                 280                 285             


Lys Pro Val Leu Glu Ser Lys Asp Phe Glu Phe Arg Phe Val Leu Asp 
    290                 295                 300                 


Gly Ile Asn Glu Leu Lys Arg Cys Pro Lys Asp Leu Phe His His Phe 
305                 310                 315                 320 


Pro Asp Gln Asn Lys Glu Leu Cys Gln Thr Thr Ala Glu Val Gln Met 
                325                 330                 335     


Glu Lys Glu Glu Thr Gly Glu Met Glu Met Glu Ser Arg Lys Val Asp 
            340                 345                 350         


Leu Ile Arg Tyr Glu Asp Lys Phe Pro Tyr Phe Ala Leu Arg Tyr Leu 
        355                 360                 365             


Asp Glu Met Asn Leu Leu Pro Lys Ile Arg Phe Gln Val Cys Ile Gly 
    370                 375                 380                 


His Arg Lys Glu Lys Phe His Thr His Asp Asn Ala Thr Glu Pro Val 
385                 390                 395                 400 


Val His His Lys Arg Val Tyr Ala Phe Thr Ser Leu His Lys Leu Leu 
                405                 410                 415     


Gln Glu Asn Pro Tyr Thr Glu Gln Phe Leu Asn Glu Asp Gly Ile Lys 
            420                 425                 430         


Glu His His Leu Lys Pro Gly Ser Gly Leu Glu Asn Phe Ala Pro Thr 
        435                 440                 445             


Tyr Ala Ile His Asp Gln Asn Ile Lys Phe Val Ile Gln Ala Glu Lys 
    450                 455                 460                 


Phe Asp Lys Phe Pro Asp Leu Cys Glu Glu Asn Pro Lys Ala Ile Leu 
465                 470                 475                 480 


Ala Asp Gly Ile Ile Ser Ile Tyr Glu Leu Lys Asn Leu Val Tyr Ala 
                485                 490                 495     


Cys Leu Leu Gly Arg Gly Glu Arg Ala Lys Ala Glu Asn Lys Leu Leu 
            500                 505                 510         


Asn Gln Val Lys Asn Tyr Asn Lys Phe Leu Ser Asp Leu Gln Cys Gly 
        515                 520                 525             


Val Phe Pro Asn Ile Asn Tyr Met Ala Glu Lys Asn Val Arg Lys Glu 
    530                 535                 540                 


Glu Phe Asn Ser Tyr Leu Ala Lys Asn Tyr Gln Met Gln Asn Thr His 
545                 550                 555                 560 


Ile Pro Lys Gln Ile Arg Arg Ser Leu Leu Gln Ile Lys Gln Ala Ser 
                565                 570                 575     


Tyr Gln Glu Lys Ala Leu Lys Lys Trp Glu Leu Trp His Asn Asp Asn 
            580                 585                 590         


Glu Glu Lys Phe Tyr Arg Leu Lys Asn Tyr Leu Asp Leu Ala Gly Thr 
        595                 600                 605             


Glu Asp Gln Pro Lys Leu Lys Lys Gly Ser Leu Ala Asn Glu Leu Thr 
    610                 615                 620                 


Arg Asp Ile Gln Phe Phe Leu Pro Glu Lys Tyr Lys Leu Glu Leu Phe 
625                 630                 635                 640 


Glu Tyr Ser Asn Leu Gln Lys Ala Leu Ala Phe Tyr Gln Glu Gly Glu 
                645                 650                 655     


Val Glu Arg Leu Leu Arg Arg Glu Leu Gln Leu Ser Tyr Phe Glu Lys 
            660                 665                 670         


Thr Asp Lys Glu Asn Asn Lys Tyr Asp Leu Phe Phe Glu Lys Lys His 
        675                 680                 685             


Pro Phe Leu His Lys Val Phe Gln Val Glu Ser Phe Asn Pro Arg Ala 
    690                 695                 700                 


Arg Phe Pro Lys Pro Lys Val Ile Lys Asn Asp Asn Ser Ser Leu Phe 
705                 710                 715                 720 


His Phe Ala Gln Asn Tyr Tyr Lys Gln Lys Arg Lys Trp Leu Glu Asn 
                725                 730                 735     


Val Asn Arg Phe Leu His Lys Thr Asp Thr Ser Ser Leu Lys Glu Ala 
            740                 745                 750         


Gln Gly Leu Leu Tyr Tyr Phe Lys Leu Gly Thr Ser Glu Glu Asn Gly 
        755                 760                 765             


Lys Arg Ile Tyr His Arg Glu Tyr Gly Ser Arg Tyr Leu Lys Pro Leu 
    770                 775                 780                 


Ile Ala Asp Ile Lys Ala His Asn Ile Pro Val Asn Met Pro Ser Gly 
785                 790                 795                 800 


Leu Phe Arg Asp Ile Leu Ala Arg Ala Gly Val Ser Asp Gln Asn Asn 
                805                 810                 815     


Ala Ser Arg Gln Ile Glu Cys Asp Phe Pro Ala Thr Gln Ala Phe Tyr 
            820                 825                 830         


Gln Phe Gln Arg Gln His Pro Ile His Lys Gln Glu Val Asp Leu Glu 
        835                 840                 845             


Gln Ile His Ser Glu Tyr Arg His Leu His Lys Met Glu Tyr Arg Asn 
    850                 855                 860                 


Glu Lys Glu Asn Lys Ser His Lys Thr Leu Tyr Tyr Phe Leu Lys Arg 
865                 870                 875                 880 


Glu Gln Lys Ile Arg Tyr Tyr Gln Thr Cys Asp Arg Leu Leu Trp Lys 
                885                 890                 895     


Met Ile Gln Glu Tyr Leu Gln Leu Arg Cys Lys Asp Met Asn Leu Asp 
            900                 905                 910         


Phe Ser Glu Ile Asp Leu Cys Asp Ile Tyr Thr Pro Ser Val Asp Gly 
        915                 920                 925             


Gln Glu Met Val Asn Ala Leu Glu Glu Lys Lys Val Glu Ile Ser Phe 
    930                 935                 940                 


Pro Ile Gly Asp Arg Lys Phe Cys Ile Gln Glu Lys Leu Lys Asn Phe 
945                 950                 955                 960 


Gly Arg Ile Ala Arg Tyr Arg Tyr Asp Ser Arg Phe Val Ser Leu Phe 
                965                 970                 975     


Arg Tyr Lys Gly Glu Asp Leu Tyr Ala Gly Arg Pro Glu Glu Glu Val 
            980                 985                 990         


His Ala Lys Ile Ala Gly Ala Leu  His Asp Phe Thr Arg  Glu Gln Leu 
        995                 1000                 1005             


Glu Leu  Phe Glu Ala Val His  Val Phe Glu Gln Phe  Ile His Glu 
    1010                 1015                 1020             


Thr Cys  Ala Asp Lys Leu Glu  Ser Trp Gln Asn Glu  Ile Arg Glu 
    1025                 1030                 1035             


Lys Asn  Gln Gln Ala Asp Arg  Ser Lys Gln Met Ala  Leu His Tyr 
    1040                 1045                 1050             


Phe Ser  His Cys Phe Leu Met  Gln Lys Ala Leu Ala  Met Gly Ile 
    1055                 1060                 1065             


Ile Pro  Asp Ala Asp Lys Met  Glu Leu Leu Ile Gln  Ala Arg Asn 
    1070                 1075                 1080             


Ser Ala  Ala His Asn Lys Val  Asn Glu Gln Tyr Ile  Arg Leu Ser 
    1085                 1090                 1095             


Thr Glu  Ala Cys Arg Asp Asn  Tyr Phe Gly Glu Ala  Ile Gln Leu 
    1100                 1105                 1110             


Tyr Lys  Gln Ile Ile His Cys  His Asp Ile Ile Thr  Asn 
    1115                 1120                 1125     


<210>  1827
<211>  1081
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1827

Met Gln Ala Gln Ser Leu Phe Asp Glu Tyr Lys His Leu Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Val Met Ser Ile Met Asn Ile Ile Thr Val Leu Asn His Ile 
            20                  25                  30          


His Gln Ile Ala Gly Leu Lys Arg Asn Glu Leu Gly Asp Asp Asp Asn 
        35                  40                  45              


Ile Tyr Ser His Pro Val Leu Lys Tyr Ile Ala Pro Glu Asn Asn Ser 
    50                  55                  60                  


Thr Thr Leu Pro Glu Lys Arg Asp Leu Ile Lys Glu Leu Leu Leu Glu 
65                  70                  75                  80  


Tyr Leu Pro Phe Leu Glu Ala Met Lys Asp Cys Tyr Lys Glu Val Lys 
                85                  90                  95      


Val Glu Lys Asp Lys Arg Asn Asn Lys Tyr Val Lys Asp Lys Lys Gln 
            100                 105                 110         


Val Phe Ile Arg Asn Tyr Ser Asp Ile Tyr Cys Ile Tyr Trp Thr Leu 
        115                 120                 125             


Tyr Asn Ile Phe Ser Thr Leu Ile Asn Tyr Arg Asp Lys Ser Cys His 
    130                 135                 140                 


Tyr Arg Phe Ile Pro Ser Lys Asp Gln Glu Glu Tyr Ser Lys Arg Thr 
145                 150                 155                 160 


Glu Tyr Asp Thr Val Arg Ile Ile Asn Lys Tyr Tyr Thr Tyr Ala Leu 
                165                 170                 175     


Arg Lys Thr Lys Glu Lys Tyr Gly Tyr Thr Thr Glu Gln Leu Ser Phe 
            180                 185                 190         


Ile Gln Asn Asn Arg Tyr Thr Asp Asp Lys Lys Val Asn Phe Asn Phe 
        195                 200                 205             


Phe Leu Ser Met Gln Ser Ser Asn Asn Asn Leu Ser His Val Gly Val 
    210                 215                 220                 


Ala Gln Leu Ile Cys Leu Phe Leu Gln Lys Lys Asp Val Asp Asn Phe 
225                 230                 235                 240 


Leu Glu Asn Leu Pro Ile Tyr Asp Asn Arg Tyr Cys Leu Gly Ile Asp 
                245                 250                 255     


Glu His Met Ile Ile Lys Arg Ser Leu Ala Leu His Ser Ile Lys Leu 
            260                 265                 270         


Pro Lys Glu Arg Leu Asn Ser Glu Lys Lys Asp Met Ala Ile Ala Met 
        275                 280                 285             


Asp Met Leu Asn Glu Leu Lys Arg Cys Pro Lys Glu Leu Phe Asn Thr 
    290                 295                 300                 


Leu Pro Phe Asp Lys Gln Glu Arg Phe Arg Ile Ile Ser Ser Asp His 
305                 310                 315                 320 


Lys Glu Val Leu Leu Met Arg Ser Thr Asp Arg Phe Val Pro Leu Ile 
                325                 330                 335     


Leu Gln Tyr Ile Asp Cys Asn Lys Lys Phe Lys Asp Ile Arg Phe His 
            340                 345                 350         


Val Asn Met Gly Lys Leu Arg Tyr Leu Phe Ser Pro Asn Lys Leu Cys 
        355                 360                 365             


Ile Asp Asn Gln Glu Arg Val Arg Met Leu Glu His Leu Leu Asn Gly 
    370                 375                 380                 


Tyr Gly Arg Ile Asp Glu Val Glu Tyr Leu Arg Lys Ala Pro Asn Gly 
385                 390                 395                 400 


Thr Phe Gly Asn Thr Asn Ile Pro Ile Lys Gly Phe Gly Glu Ile Glu 
                405                 410                 415     


Arg Asp Ser Ala Asp Ser Asn Asn Tyr Pro Tyr Ile Val Asp Thr His 
            420                 425                 430         


Thr His Tyr Ile Leu Asn Asn Asn Lys Val Glu Phe Cys Phe Cys Glu 
        435                 440                 445             


Asp Ser Lys Asn Lys Asn Val Phe Pro Thr Ile Glu Lys Glu Ile Asn 
    450                 455                 460                 


Gly Lys Trp Tyr Val Glu Lys Thr Ala Pro His Cys Arg Ile Ser Phe 
465                 470                 475                 480 


Phe Glu Ile Pro Ala Met Ala Phe His Met Phe Leu Cys Gly Ser Glu 
                485                 490                 495     


Lys Thr Glu Lys Leu Ile Lys Asp Val Tyr Asn Asn Tyr Ile Ser Leu 
            500                 505                 510         


Phe Asn Ala Leu Lys Asn Gly Ala Leu Thr Glu Glu Asn Tyr Lys Asp 
        515                 520                 525             


Phe Asn Ile Pro Glu Cys Asp Met Pro Lys Lys Ile Leu Asp Phe Leu 
    530                 535                 540                 


Lys Gly Lys Ala Glu Gly Lys Ser Ile Asp Gly Tyr Val Lys Asn Ile 
545                 550                 555                 560 


Leu Lys Lys Glu Leu Lys Asp Thr Arg Lys Arg Ile Glu Gln Ala Pro 
                565                 570                 575     


Ser Glu Lys Asp Gln Met Pro Ser Lys Arg Asn Lys Ile Gly Thr Lys 
            580                 585                 590         


Ser Tyr Lys Arg Val Leu Thr Gly Lys Leu Ala Asp Phe Leu Ala Lys 
        595                 600                 605             


Asp Ile Val Lys Tyr Gln Pro Thr Leu Cys Ala Gly Asp Asp Tyr Gly 
    610                 615                 620                 


Ile Asp Arg Met Thr Gly Met Asn Tyr Arg Ile Met Gln Ala Thr Ile 
625                 630                 635                 640 


Ala Thr Tyr Asn Asp Asp Asp Asp Phe Asp Thr Phe Tyr Asn Val Phe 
                645                 650                 655     


Lys Met Ala Gly Leu Val Asp Gly Asp Glu Arg Lys Asn His Pro Phe 
            660                 665                 670         


Leu Lys Lys Val Leu Leu Ser Lys Pro Gln Asn Thr Val Ala Phe Asn 
        675                 680                 685             


Ile Lys Tyr Leu Lys Glu Lys Glu Ile Tyr Leu Arg Asn Ile Glu Lys 
    690                 695                 700                 


Lys Asn Ile Ile Pro Pro Phe Val Asn Arg Glu Arg Asn Lys Trp Cys 
705                 710                 715                 720 


Glu Arg Asp Cys Glu Tyr Tyr Arg Ile Leu Gly Glu Asn Leu Leu Asp 
                725                 730                 735     


Leu Pro Ile Glu Leu Pro Arg Gln Met Phe Tyr Lys Asp Ile Arg Ala 
            740                 745                 750         


Gln Leu Glu Pro Leu Met Pro Glu Ile Asp Phe Ser Gln Thr Asn Thr 
        755                 760                 765             


Thr Tyr Leu Ile Ala Glu Tyr Leu Lys Arg Val Arg Gly Asp Asp Phe 
    770                 775                 780                 


Gln Glu Phe Tyr Ser Trp Glu Arg Asn Tyr Arg Tyr Ile Asp Phe Leu 
785                 790                 795                 800 


Lys Cys Ile Arg Asp Asp Asn Gly Arg Ile Cys Ala Gln Tyr Thr Thr 
                805                 810                 815     


Thr Glu Glu Arg Glu Ser Leu Trp Glu Asp Ser Lys Asn Arg Thr Ala 
            820                 825                 830         


Glu Tyr Lys Arg Ser Glu Glu Gln Lys Asn Glu Lys Lys Asp Lys Asn 
        835                 840                 845             


Phe Glu Asp Ser Leu Glu Glu Arg Ile Ser Ser Ser His Ile Lys Phe 
    850                 855                 860                 


Gln Asn Thr Glu Lys His Ile Arg Arg Tyr Lys Val Gln Asp Ala Leu 
865                 870                 875                 880 


Leu Phe Met Ile Ala Glu Lys Gln Phe Gly Lys Tyr Leu Asp Asp Ile 
                885                 890                 895     


Lys Ala Lys Asn Phe Lys Leu Lys Asp Ile Met Pro Asp Thr Asp Lys 
            900                 905                 910         


Gly Ile Leu Ser Glu Thr Met Pro Ile Asp Phe Thr Phe Thr Lys Lys 
        915                 920                 925             


Asn Ile Lys Tyr Asn Ile His Ala Lys Asn Leu Lys Phe Lys Glu Tyr 
    930                 935                 940                 


Gly Asp Leu Phe Ile Leu Ala Asn Asp Lys Arg Leu Glu Ser Leu Trp 
945                 950                 955                 960 


Lys Ile Leu Ala Thr Asp Thr Val Asn Lys Glu Glu Ile Ser Glu Glu 
                965                 970                 975     


Phe Ala Lys Tyr Asp Phe Cys Arg Pro Asp Ile Thr Lys Leu Val Leu 
            980                 985                 990         


Asp Phe Glu Lys Asp Val Leu Glu  Lys Tyr Pro Glu Ile  Ile Glu Glu 
        995                 1000                 1005             


Ala Glu  Lys Glu Tyr Lys Lys  Phe Asp Phe Lys Phe  Ile Leu Asp 
    1010                 1015                 1020             


Trp Leu  Ile Asn Lys Lys Lys  Leu Asn Tyr Gly Ile  Arg Asn Lys 
    1025                 1030                 1035             


Leu Leu  Leu Ile Arg Asn Ala  Phe Asn His Asn Ser  Tyr Pro Asp 
    1040                 1045                 1050             


Lys Lys  Tyr Ala Glu Val Arg  Glu Leu Pro Glu Ile  Ala Thr Asn 
    1055                 1060                 1065             


Leu Lys  Lys Thr Phe Asp Glu  Asn Ala Lys Lys Tyr  Glu 
    1070                 1075                 1080     


<210>  1828
<211>  1164
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1828

Met Thr Ala Thr Asn Gly Leu Gly Lys Gly Ile Ser Tyr His His His 
1               5                   10                  15      


Leu Tyr Ala Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Asp 
            20                  25                  30          


Asp Asn Ile Asp Gln Val Lys Gln Leu Phe Asp Thr Arg Phe Gly Glu 
        35                  40                  45              


Lys Asn Ala Asp Arg Phe Phe Ser Thr Lys Asn Asn His Leu Ile Ala 
    50                  55                  60                  


Tyr Asp Asp Trp Glu Lys Gly Ile Asp Phe Leu Lys Gln Tyr Leu Pro 
65                  70                  75                  80  


Val Val His Tyr Leu Ala Leu Pro Val Asn His Glu Lys Phe Ser Asn 
                85                  90                  95      


Leu Thr Asp Lys Glu Lys Gly Arg Arg Asp Tyr Phe Thr Ile His Phe 
            100                 105                 110         


Asn Leu Leu Thr Ser Thr Ile His Asp Cys Arg Asn Phe Tyr Thr His 
        115                 120                 125             


Tyr Tyr His Asp Pro Ile Thr Val Gln Asn Asp Leu Phe Gln Leu Leu 
    130                 135                 140                 


Asp Glu Leu Phe Ile Leu Val Cys Arg Asp Val Arg Lys His Arg Ile 
145                 150                 155                 160 


Lys Thr Asp Lys Thr Gly Trp Leu Leu Lys Arg Thr Leu Gln Asn Glu 
                165                 170                 175     


Leu Gln Ile Leu Thr Lys His Lys Lys His Thr Leu Glu Lys Gln Lys 
            180                 185                 190         


Lys Glu Gly Lys Lys Val Asn Leu Asp Ala Glu Ala Ile Glu Asn Ala 
        195                 200                 205             


Val Met Asn Asp Ala Phe Lys His Leu Arg Tyr Thr Asp Lys Glu Asp 
    210                 215                 220                 


Asn Lys Gly Asn Ile Lys Lys Phe Leu Val Lys Asp Gln Tyr Lys Ser 
225                 230                 235                 240 


Ala Tyr Asn Arg Gln Glu Pro Ser Glu Asn Gly Ile Cys Leu Ser Arg 
                245                 250                 255     


Ser Gly Leu Leu Phe Leu Cys Ser Met Phe Leu Ser Arg Lys Ala Gly 
            260                 265                 270         


Glu Asp Met Arg Ala Arg Val Ser Gly Phe Lys Glu Lys Phe Val Tyr 
        275                 280                 285             


Arg Thr Glu Glu Glu Ile Thr Asp Lys Asn Asn Ser Leu Arg Ser Met 
    290                 295                 300                 


Val Thr Gln Trp Val Phe Ser His Leu Ala Phe Lys Asp Ile Lys Gln 
305                 310                 315                 320 


Arg Ile Thr Thr Asn Leu Asp Arg Glu Thr Leu Phe Val Gln Ile Val 
                325                 330                 335     


Asp Tyr Leu Ser Lys Val Pro Asp Glu Leu Tyr Gln Val Phe Ser Asn 
            340                 345                 350         


Thr Gln Lys Leu Asp Phe Leu Glu Asp Ile Asn Glu Tyr Ile Lys Glu 
        355                 360                 365             


Gly Asn Lys Thr Glu Ser Leu Ile Gln Ser Thr Val Ala His Pro Val 
    370                 375                 380                 


Ile Arg Lys Arg Tyr Glu Asn Gln Phe Asn Tyr Phe Val Leu Arg Tyr 
385                 390                 395                 400 


Leu Asp Glu Phe Val Glu Phe Pro Ser Leu Arg Phe Gln Ile Asn Thr 
                405                 410                 415     


Gly Phe Tyr Thr His Asp Gln Arg Glu Lys Thr Ile Glu Gly Thr Glu 
            420                 425                 430         


Tyr Leu Thr Asp Arg Lys Ile Lys Glu Lys Ile Lys Val Phe Gly Lys 
        435                 440                 445             


Leu Ser Glu Val Thr Thr Gln Lys Asn Glu Phe Leu Val Lys Asn Thr 
    450                 455                 460                 


Asp Leu Gln Gly Trp Glu Ala Tyr Pro Gly Pro Ser Tyr Asn Val Asn 
465                 470                 475                 480 


Asn Asn Asn Ile Pro Val Phe Ile Asn Met Gln Asn Asn Ala Val Asn 
                485                 490                 495     


Gly Ser Lys Gln Trp Tyr Ser Lys Ile Asn Phe Lys Ile Arg Asn Glu 
            500                 505                 510         


Arg Asn Leu Lys Gln Ser Pro Arg Thr Glu Asp Lys Lys Gln Lys Ser 
        515                 520                 525             


Ala Ile Ala Asp Met Leu Lys Ile Asn Gly Glu Met Asp Leu Arg Tyr 
    530                 535                 540                 


Glu Glu Pro Thr Ala Ile Leu Cys Leu Lys Glu Leu Pro Ser Leu Leu 
545                 550                 555                 560 


Tyr Glu Leu Leu Tyr Thr Lys Ala Ser Pro Lys Glu Ile Glu Glu His 
                565                 570                 575     


Leu Leu Lys Lys Ile Ile Gly His Leu Asp Thr Ile Glu Lys Tyr Ala 
            580                 585                 590         


His His Thr Asp Ser Ser Leu Gln Gly Met Pro Arg Lys Leu Lys Lys 
        595                 600                 605             


Ser Gly Glu Glu Ser Ser Ile Asn Tyr Lys Lys Leu Arg Glu Val Ile 
    610                 615                 620                 


Val Asn Glu Leu Lys Val Ile Thr Glu Lys Gln Asp Phe Leu Lys Glu 
625                 630                 635                 640 


Lys Gln Lys Asp Lys Lys Val Asn Lys Arg Leu Tyr Leu Leu Asn Asn 
                645                 650                 655     


Arg Glu Met Gly Lys Glu Ala Thr Trp Leu Ala Ser Asp Leu Ile Arg 
            660                 665                 670         


Phe Met Pro Glu Thr Ala Arg Lys Gln Trp Lys Gly Tyr His His Ser 
        675                 680                 685             


Gln Leu Gln Gln Thr Leu Ala Phe Tyr Gln Gln Lys Arg Lys Glu Ala 
    690                 695                 700                 


Leu Ser Leu Ile Gly Gln Phe Trp Asp Phe Asn Thr Gly Pro Tyr Trp 
705                 710                 715                 720 


Gly Asp Lys Leu Lys Lys Ala Phe Glu Gln Thr Thr Phe Glu Asp Phe 
                725                 730                 735     


Tyr Phe Glu Tyr Leu Lys Met Arg Gln Ala Ile Leu Asn Asn Phe Leu 
            740                 745                 750         


Glu Asn Val Ser Ser Ser Gln Asn Gln Pro Asn Leu Ala Lys Lys Ala 
        755                 760                 765             


Leu Lys Asp Cys Trp Ile Ile Phe His Lys Arg His Phe Ile Ile Arg 
    770                 775                 780                 


Pro Ala Lys Glu Gln Ile Ser Ser Leu Leu Ala Gln Pro Val Val Leu 
785                 790                 795                 800 


Pro Arg Gly Leu Phe Asp Asn Lys Pro Thr Tyr Ile Lys Asp Val Lys 
                805                 810                 815     


Leu Glu Asp Ala Pro Glu Lys Phe Ala Asn Trp Tyr Arg Tyr Thr Tyr 
            820                 825                 830         


Asn Asp Tyr Pro Met Gln Arg Phe Tyr Ser Phe Asp Arg Asp Tyr Thr 
        835                 840                 845             


Ser Leu Tyr Glu Glu Phe Gln Ser Asn Lys Asp Val Ile Leu Asn Lys 
    850                 855                 860                 


Lys Arg Leu Thr Lys Ser Glu Gln Glu Ala Leu Leu Lys Lys Lys Gln 
865                 870                 875                 880 


Asp Leu Lys Ile Lys Asp Ile Arg Thr Gln Asp Leu Phe Leu Lys Leu 
                885                 890                 895     


Ile Ala Asp Lys Leu Phe Glu Asp Ile Phe Asp Gln Lys Ala Asp Phe 
            900                 905                 910         


Thr Leu Glu Asp Ile Tyr Gln Thr Arg Glu Glu Arg Met Gln Asn Gly 
        915                 920                 925             


Glu Gln Ala Leu Gln Gln Ser Glu Arg Ala Pro Gly Asp Asp Phe Glu 
    930                 935                 940                 


Asn Ile Tyr Asn Glu Ser Phe Val Leu Asn Lys Thr Val Pro Phe Ile 
945                 950                 955                 960 


Gln Lys Gln Ile His Glu Pro Thr Val Lys Ile Lys Asp Leu Gly Lys 
                965                 970                 975     


Phe Lys Arg Phe Leu Phe Asp Asn Lys Val Lys Ala Leu Phe Ser Tyr 
            980                 985                 990         


Glu Pro Asn Arg Val Trp Ser Ile  Gln Glu Leu Glu Asn  Glu Leu Thr 
        995                 1000                 1005             


Leu Leu  Pro Thr Ser Tyr Glu  Val Ile Arg Arg Val  Ser Leu Leu 
    1010                 1015                 1020             


Lys Ala  Ile Gln Glu Phe Glu  Lys Tyr Ile Met Glu  Cys Trp Gly 
    1025                 1030                 1035             


Asp Ser  Asp Thr Thr Lys Leu  Asp Gln Lys Asp Lys  Lys Ser Gly 
    1040                 1045                 1050             


Lys Tyr  Asn Pro Ser Phe Lys  Lys Tyr Ile Phe Asn  Gly Val Leu 
    1055                 1060                 1065             


Asp Lys  Phe Arg Leu Ala Asn  Ala Glu Asn Ile Lys  His Ile Ile 
    1070                 1075                 1080             


Asp Tyr  Lys Lys Phe Glu Glu  Leu Val Asp Asp Pro  Gln Leu Lys 
    1085                 1090                 1095             


Ser Phe  Glu Glu Ile Val Arg  Lys Ala Tyr Ile Leu  Thr Ile Ile 
    1100                 1105                 1110             


Arg Asn  Lys Ile Ala His Asn  Gln Leu Pro Asp Lys  Ala Asn Met 
    1115                 1120                 1125             


Asp Phe  Ile Gln Gly Met Tyr  Pro Lys Glu Pro Gln  Asp Ser Tyr 
    1130                 1135                 1140             


Ser Gln  Tyr Leu Leu Arg Val  Thr Gln Leu Ile Ile  Asp Glu Met 
    1145                 1150                 1155             


Val Leu  Leu Met Lys Ile 
    1160                 


<210>  1829
<211>  1164
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1829

Met Thr Ala Thr Asn Gly Leu Gly Lys Gly Ile Ser Tyr His His His 
1               5                   10                  15      


Leu Tyr Ala Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Asp 
            20                  25                  30          


Asp Asn Ile Asp Gln Val Lys Gln Leu Phe Asp Thr Arg Phe Gly Glu 
        35                  40                  45              


Lys Asn Ala Asp Arg Phe Phe Ser Thr Lys Asn Asn His Leu Ile Ala 
    50                  55                  60                  


Tyr Asp Asp Trp Glu Lys Gly Ile Asp Phe Leu Lys Gln Tyr Leu Pro 
65                  70                  75                  80  


Val Val His Tyr Leu Ala Leu Pro Val Asn His Glu Lys Phe Ser Asn 
                85                  90                  95      


Leu Thr Asp Lys Glu Lys Gly Arg Arg Asp Tyr Phe Thr Ile His Phe 
            100                 105                 110         


Asn Leu Leu Thr Ser Thr Ile His Asp Cys Arg Asn Phe Tyr Thr His 
        115                 120                 125             


Tyr Tyr His Asp Pro Ile Thr Val Gln Asn Asp Leu Phe Gln Leu Leu 
    130                 135                 140                 


Asp Glu Leu Phe Ile Leu Val Cys Arg Asp Val Arg Lys His Arg Ile 
145                 150                 155                 160 


Lys Thr Asp Lys Thr Gly Trp Leu Leu Lys Arg Thr Leu Gln Asn Glu 
                165                 170                 175     


Leu Gln Ile Leu Thr Lys His Lys Lys His Thr Leu Glu Lys Gln Lys 
            180                 185                 190         


Lys Glu Gly Lys Lys Val Asn Leu Asp Ala Glu Ala Ile Glu Asn Ala 
        195                 200                 205             


Val Met Asn Asp Ala Phe Lys His Leu Arg Tyr Thr Asp Lys Glu Asp 
    210                 215                 220                 


Asn Lys Gly Asn Ile Lys Lys Phe Leu Val Lys Asp Gln Tyr Lys Ser 
225                 230                 235                 240 


Ala Tyr Asn Arg Gln Glu Pro Ser Glu Asn Gly Ile Cys Leu Ser Arg 
                245                 250                 255     


Ser Gly Leu Leu Phe Leu Cys Ser Met Phe Leu Ser Arg Lys Ala Gly 
            260                 265                 270         


Glu Asp Met Arg Ala Arg Val Ser Gly Phe Lys Glu Lys Phe Val Tyr 
        275                 280                 285             


Arg Thr Glu Glu Glu Ile Thr Asp Lys Asn Asn Ser Leu Arg Ser Met 
    290                 295                 300                 


Val Thr Gln Trp Val Phe Ser His Leu Ala Phe Lys Asp Ile Lys Gln 
305                 310                 315                 320 


Arg Ile Thr Thr Asn Leu Asp Arg Glu Thr Leu Phe Val Gln Ile Val 
                325                 330                 335     


Asp Tyr Leu Ser Lys Val Pro Asp Glu Leu Tyr Gln Val Phe Ser Asn 
            340                 345                 350         


Thr Gln Lys Leu Asp Phe Leu Glu Asp Ile Asn Glu Tyr Ile Lys Glu 
        355                 360                 365             


Gly Asn Lys Thr Glu Ser Leu Ile Gln Ser Thr Val Ala His Pro Val 
    370                 375                 380                 


Ile Arg Lys Arg Tyr Glu Asn Gln Phe Asn Tyr Phe Val Leu Arg Tyr 
385                 390                 395                 400 


Leu Asp Glu Phe Val Glu Phe Pro Ser Leu Arg Phe Gln Ile Asn Thr 
                405                 410                 415     


Gly Phe Tyr Thr His Asp Gln Arg Glu Lys Thr Ile Glu Gly Thr Glu 
            420                 425                 430         


Tyr Leu Thr Asp Arg Lys Ile Lys Glu Lys Ile Lys Val Phe Gly Lys 
        435                 440                 445             


Leu Ser Glu Val Thr Thr Gln Lys Asn Glu Phe Leu Val Lys Asn Thr 
    450                 455                 460                 


Asp Leu Gln Gly Trp Glu Ala Tyr Pro Gly Pro Ser Tyr Asn Val Asn 
465                 470                 475                 480 


Asn Asn Asn Ile Pro Val Phe Ile Asn Met Gln Asn Asn Ala Val Asn 
                485                 490                 495     


Gly Ser Lys Gln Trp Tyr Ser Lys Ile Asn Phe Lys Ile Arg Asn Glu 
            500                 505                 510         


Arg Asn Leu Lys Gln Ser Pro Arg Thr Glu Asp Lys Lys Gln Lys Ser 
        515                 520                 525             


Ala Ile Ala Asp Met Leu Lys Ile Asn Gly Glu Met Asp Leu Arg Tyr 
    530                 535                 540                 


Glu Glu Pro Thr Ala Ile Leu Cys Leu Lys Glu Leu Pro Ser Leu Leu 
545                 550                 555                 560 


Tyr Glu Leu Leu Tyr Thr Lys Ala Ser Pro Lys Glu Ile Glu Glu His 
                565                 570                 575     


Leu Leu Lys Lys Ile Ile Gly His Leu Asp Thr Ile Glu Lys Tyr Ala 
            580                 585                 590         


His His Thr Asp Ser Ser Leu Gln Gly Met Pro Arg Lys Leu Lys Lys 
        595                 600                 605             


Ser Gly Glu Glu Ser Ser Ile Asn Tyr Lys Lys Leu Arg Glu Val Ile 
    610                 615                 620                 


Val Asn Glu Leu Lys Val Ile Thr Glu Lys Gln Asp Phe Leu Lys Glu 
625                 630                 635                 640 


Lys Gln Lys Asp Lys Lys Val Asn Lys Arg Leu Tyr Leu Leu Asn Asn 
                645                 650                 655     


Arg Glu Met Gly Lys Glu Ala Thr Trp Leu Ala Ser Asp Leu Ile Arg 
            660                 665                 670         


Phe Met Pro Glu Thr Ala Arg Lys Gln Trp Lys Gly Tyr His His Ser 
        675                 680                 685             


Gln Leu Gln Gln Thr Leu Ala Phe Tyr Gln Gln Lys Arg Lys Glu Ala 
    690                 695                 700                 


Leu Ser Leu Ile Gly Gln Phe Trp Asp Phe Asn Thr Gly Pro Tyr Trp 
705                 710                 715                 720 


Gly Asp Lys Leu Lys Lys Ala Phe Glu Gln Thr Thr Phe Glu Asp Phe 
                725                 730                 735     


Tyr Phe Glu Tyr Leu Lys Met Arg Gln Ala Ile Leu Asn Asn Phe Leu 
            740                 745                 750         


Glu Asn Val Ser Ser Ser Gln Asn Gln Pro Asn Leu Ala Lys Lys Ala 
        755                 760                 765             


Leu Lys Asp Cys Trp Ile Ile Phe His Lys Arg His Phe Ile Ile Arg 
    770                 775                 780                 


Pro Ala Lys Glu Gln Ile Ser Ser Leu Leu Ala Gln Pro Val Val Leu 
785                 790                 795                 800 


Pro Arg Gly Leu Phe Asp Asn Lys Pro Thr Tyr Ile Lys Asp Val Lys 
                805                 810                 815     


Leu Glu Asp Ala Pro Glu Lys Phe Ala Asn Trp Tyr Arg Tyr Thr Tyr 
            820                 825                 830         


Asn Asp Tyr Pro Met Gln Arg Phe Tyr Ser Phe Asp Arg Asp Tyr Thr 
        835                 840                 845             


Ser Leu Tyr Glu Glu Phe Gln Ser Asn Lys Asp Val Ile Leu Asn Lys 
    850                 855                 860                 


Lys Arg Leu Thr Lys Ser Glu Gln Glu Ala Leu Leu Lys Lys Lys Gln 
865                 870                 875                 880 


Asp Leu Lys Ile Lys Asp Ile Arg Thr Gln Asp Leu Phe Leu Lys Leu 
                885                 890                 895     


Ile Ala Asp Lys Leu Phe Glu Asp Ile Phe Asp Gln Lys Ala Asp Phe 
            900                 905                 910         


Thr Leu Glu Asp Ile Tyr Gln Thr Arg Glu Glu Arg Met Gln Asn Gly 
        915                 920                 925             


Glu Gln Ala Leu Gln Gln Ser Glu Arg Ala Pro Gly Asp Asp Phe Glu 
    930                 935                 940                 


Asn Ile Tyr Asn Glu Ser Phe Val Leu Asn Lys Thr Val Pro Phe Ile 
945                 950                 955                 960 


Gln Lys Gln Ile His Glu Pro Thr Val Lys Ile Lys Asp Leu Gly Lys 
                965                 970                 975     


Phe Lys Arg Phe Leu Phe Asp Asn Lys Val Lys Ala Leu Phe Ser Tyr 
            980                 985                 990         


Glu Pro Asn Arg Val Trp Ser Ile  Gln Glu Leu Glu Asn  Glu Leu Thr 
        995                 1000                 1005             


Leu Leu  Pro Thr Ser Tyr Glu  Val Ile Arg Arg Val  Ser Leu Leu 
    1010                 1015                 1020             


Lys Ala  Ile Gln Glu Phe Glu  Lys Tyr Ile Met Glu  Cys Trp Gly 
    1025                 1030                 1035             


Asp Ser  Asp Thr Thr Lys Leu  Asp Gln Lys Asp Lys  Lys Ser Gly 
    1040                 1045                 1050             


Lys Tyr  Asn Pro Ser Phe Lys  Lys Tyr Ile Phe Asn  Gly Val Leu 
    1055                 1060                 1065             


Asp Lys  Phe Arg Leu Ala Asn  Ala Glu Asn Ile Lys  His Ile Ile 
    1070                 1075                 1080             


Asp Tyr  Lys Lys Phe Glu Glu  Leu Val Asp Asp Pro  Gln Leu Lys 
    1085                 1090                 1095             


Ser Phe  Glu Glu Ile Val Arg  Lys Ala Tyr Ile Leu  Thr Ile Ile 
    1100                 1105                 1110             


Arg Asn  Lys Ile Ala His Asn  Gln Leu Pro Asp Lys  Ala Asn Met 
    1115                 1120                 1125             


Asp Phe  Ile Gln Gly Met Tyr  Pro Lys Glu Pro Gln  Asp Ser Tyr 
    1130                 1135                 1140             


Ser Gln  Tyr Leu Leu Arg Val  Thr Gln Leu Ile Ile  Asp Glu Met 
    1145                 1150                 1155             


Val Leu  Leu Met Lys Ile 
    1160                 


<210>  1830
<211>  1081
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1830

Met Gln Ala Gln Ser Leu Phe Asp Glu Tyr Lys His Leu Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Val Met Ser Ile Met Asn Ile Ile Thr Val Leu Asn His Ile 
            20                  25                  30          


His Gln Ile Ala Gly Leu Lys Arg Asn Glu Leu Gly Asp Asp Asp Asn 
        35                  40                  45              


Ile Tyr Ser His Pro Val Leu Lys Tyr Ile Ala Pro Glu Asn Asn Ser 
    50                  55                  60                  


Thr Thr Leu Pro Glu Lys Arg Asp Leu Ile Lys Glu Leu Leu Leu Glu 
65                  70                  75                  80  


Tyr Leu Pro Phe Leu Glu Ala Met Lys Asp Cys Tyr Lys Glu Val Lys 
                85                  90                  95      


Val Glu Lys Asp Lys Arg Asn Asn Lys Tyr Val Lys Asp Lys Lys Gln 
            100                 105                 110         


Val Phe Ile Arg Asn Tyr Ser Asp Ile Tyr Cys Ile Tyr Trp Thr Leu 
        115                 120                 125             


Tyr Asn Ile Phe Ser Thr Leu Ile Asn Tyr Arg Asp Lys Ser Cys His 
    130                 135                 140                 


Tyr Arg Phe Ile Pro Ser Lys Asp Gln Glu Glu Tyr Ser Lys Arg Thr 
145                 150                 155                 160 


Glu Tyr Asp Thr Val Arg Ile Ile Asn Lys Tyr Tyr Thr Tyr Ala Leu 
                165                 170                 175     


Arg Lys Thr Lys Glu Lys Tyr Gly Tyr Thr Thr Glu Gln Leu Ser Phe 
            180                 185                 190         


Ile Gln Asn Asn Arg Tyr Thr Asp Asp Lys Lys Val Asn Phe Asn Phe 
        195                 200                 205             


Phe Leu Ser Met Gln Ser Ser Asn Asn Asn Leu Ser His Val Gly Val 
    210                 215                 220                 


Ala Gln Leu Ile Cys Leu Phe Leu Gln Lys Lys Asp Val Asp Asn Phe 
225                 230                 235                 240 


Leu Glu Asn Leu Pro Ile Tyr Asp Asn Arg Tyr Cys Leu Gly Ile Asp 
                245                 250                 255     


Glu His Met Ile Ile Lys Arg Ser Leu Ala Leu His Ser Ile Lys Leu 
            260                 265                 270         


Pro Lys Glu Arg Leu Asn Ser Glu Lys Lys Asp Met Ala Ile Ala Met 
        275                 280                 285             


Asp Met Leu Asn Glu Leu Lys Arg Cys Pro Lys Glu Leu Phe Asn Thr 
    290                 295                 300                 


Leu Pro Phe Asp Lys Gln Glu Arg Phe Arg Ile Ile Ser Ser Asp His 
305                 310                 315                 320 


Lys Glu Val Leu Leu Met Arg Ser Thr Asp Arg Phe Val Pro Leu Ile 
                325                 330                 335     


Leu Gln Tyr Ile Asp Cys Asn Lys Lys Phe Lys Asp Ile Arg Phe His 
            340                 345                 350         


Val Asn Met Gly Lys Leu Arg Tyr Leu Phe Ser Pro Asn Lys Leu Cys 
        355                 360                 365             


Ile Asp Asn Gln Glu Arg Val Arg Met Leu Glu His Leu Leu Asn Gly 
    370                 375                 380                 


Tyr Gly Arg Ile Asp Glu Val Glu Tyr Leu Arg Lys Ala Pro Asn Gly 
385                 390                 395                 400 


Thr Phe Gly Asn Thr Asn Ile Pro Ile Lys Gly Phe Gly Glu Ile Glu 
                405                 410                 415     


Arg Asp Ser Ala Asp Ser Asn Asn Tyr Pro Tyr Ile Val Asp Thr His 
            420                 425                 430         


Thr His Tyr Ile Leu Asn Asn Asn Lys Val Glu Phe Cys Phe Cys Glu 
        435                 440                 445             


Asp Ser Lys Asn Lys Asn Val Phe Pro Thr Ile Glu Lys Glu Ile Asn 
    450                 455                 460                 


Gly Lys Trp Tyr Val Glu Lys Thr Ala Pro His Cys Arg Ile Ser Phe 
465                 470                 475                 480 


Phe Glu Ile Pro Ala Met Ala Phe His Met Phe Leu Cys Gly Ser Glu 
                485                 490                 495     


Lys Thr Glu Lys Leu Ile Lys Asp Val Tyr Asn Asn Tyr Ile Ser Leu 
            500                 505                 510         


Phe Asn Ala Leu Lys Asn Gly Ala Leu Thr Glu Glu Asn Tyr Lys Asp 
        515                 520                 525             


Phe Asn Ile Pro Glu Cys Asp Met Pro Lys Lys Ile Leu Asp Phe Leu 
    530                 535                 540                 


Lys Gly Lys Ala Glu Gly Lys Ser Ile Asp Gly Tyr Val Lys Asn Ile 
545                 550                 555                 560 


Leu Lys Lys Glu Leu Lys Asp Thr Arg Lys Arg Ile Glu Gln Ala Pro 
                565                 570                 575     


Ser Glu Lys Asp Gln Met Pro Ser Lys Arg Asn Lys Ile Gly Thr Lys 
            580                 585                 590         


Ser Tyr Lys Arg Val Leu Thr Gly Lys Leu Ala Asp Phe Leu Ala Lys 
        595                 600                 605             


Asp Ile Val Lys Tyr Gln Pro Thr Leu Cys Ala Gly Asp Asp Tyr Gly 
    610                 615                 620                 


Ile Asp Arg Met Thr Gly Met Asn Tyr Arg Ile Met Gln Ala Thr Ile 
625                 630                 635                 640 


Ala Thr Tyr Asn Asp Asp Asp Asp Phe Asp Thr Phe Tyr Asn Val Phe 
                645                 650                 655     


Lys Met Ala Gly Leu Val Asp Gly Asp Glu Arg Lys Asn His Pro Phe 
            660                 665                 670         


Leu Lys Lys Val Leu Leu Ser Lys Pro Gln Asn Thr Val Ala Phe Asn 
        675                 680                 685             


Ile Lys Tyr Leu Lys Glu Lys Glu Ile Tyr Leu Arg Asn Ile Glu Lys 
    690                 695                 700                 


Lys Asn Ile Ile Pro Pro Phe Val Asn Arg Glu Arg Asn Lys Trp Cys 
705                 710                 715                 720 


Glu Arg Asp Cys Glu Tyr Tyr Arg Ile Leu Gly Glu Asn Leu Leu Asp 
                725                 730                 735     


Leu Pro Ile Glu Leu Pro Arg Gln Met Phe Tyr Lys Asp Ile Arg Ala 
            740                 745                 750         


Gln Leu Glu Pro Leu Met Pro Glu Ile Asp Phe Ser Gln Thr Asn Thr 
        755                 760                 765             


Thr Tyr Leu Ile Ala Glu Tyr Leu Lys Arg Val Arg Gly Asp Asp Phe 
    770                 775                 780                 


Gln Glu Phe Tyr Ser Trp Glu Arg Asn Tyr Arg Tyr Ile Asp Phe Leu 
785                 790                 795                 800 


Lys Cys Ile Arg Asp Asp Asn Gly Arg Ile Cys Ala Gln Tyr Thr Thr 
                805                 810                 815     


Thr Glu Glu Arg Glu Ser Leu Trp Glu Asp Ser Lys Asn Arg Thr Ala 
            820                 825                 830         


Glu Tyr Lys Arg Ser Glu Glu Gln Lys Asn Glu Lys Lys Asp Lys Asn 
        835                 840                 845             


Phe Glu Asp Ser Leu Glu Glu Arg Ile Ser Ser Ser His Ile Lys Phe 
    850                 855                 860                 


Gln Asn Thr Glu Lys His Ile Arg Arg Tyr Lys Val Gln Asp Ala Leu 
865                 870                 875                 880 


Leu Phe Met Ile Ala Glu Lys Gln Phe Gly Lys Tyr Leu Asp Asp Ile 
                885                 890                 895     


Lys Ala Lys Asn Phe Lys Leu Lys Asp Ile Met Pro Asp Thr Asp Lys 
            900                 905                 910         


Gly Ile Leu Ser Glu Thr Met Pro Ile Asp Phe Thr Phe Thr Lys Lys 
        915                 920                 925             


Asn Ile Lys Tyr Asn Ile His Ala Lys Asn Leu Lys Phe Lys Glu Tyr 
    930                 935                 940                 


Gly Asp Leu Phe Ile Leu Ala Asn Asp Lys Arg Leu Glu Ser Leu Trp 
945                 950                 955                 960 


Lys Ile Leu Ala Thr Asp Thr Val Asn Lys Glu Glu Ile Ser Glu Glu 
                965                 970                 975     


Phe Ala Lys Tyr Asp Phe Cys Arg Pro Asp Ile Thr Lys Leu Val Leu 
            980                 985                 990         


Asp Phe Glu Lys Asp Val Leu Glu  Lys Tyr Pro Glu Ile  Ile Glu Glu 
        995                 1000                 1005             


Ala Glu  Lys Glu Tyr Lys Lys  Phe Asp Phe Lys Phe  Ile Leu Asp 
    1010                 1015                 1020             


Trp Leu  Ile Asn Lys Lys Lys  Leu Asn Tyr Gly Ile  Arg Asn Lys 
    1025                 1030                 1035             


Leu Leu  Leu Ile Arg Asn Ala  Phe Asn His Asn Ser  Tyr Pro Asp 
    1040                 1045                 1050             


Lys Lys  Tyr Ala Glu Val Arg  Glu Leu Pro Glu Ile  Ala Thr Asn 
    1055                 1060                 1065             


Leu Lys  Lys Thr Phe Asp Glu  Asn Ala Lys Lys Tyr  Glu 
    1070                 1075                 1080     


<210>  1831
<211>  1085
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1831

Met Lys Lys Glu Leu Asn Arg Glu Asp Val Phe Thr Gly Gly Lys Thr 
1               5                   10                  15      


Pro Glu Leu Thr Ile Tyr Tyr Asn Ile Ala Tyr Phe Arg Met Ala Gly 
            20                  25                  30          


Leu Ile Asn Ala Leu Cys Gly Asn Lys Leu Glu Arg Asp Lys Asp Ala 
        35                  40                  45              


Leu Glu Gln Phe Met Lys Ala Phe Ile Asn Gly Lys Gln Lys Leu Thr 
    50                  55                  60                  


Asp Met Gln Phe Val Lys Leu Cys Asp Tyr Leu Trp Lys Gly Tyr Lys 
65                  70                  75                  80  


Tyr Asp Lys Asn Arg Ser Glu Tyr Ser Leu Thr Glu Asn Asp Lys Thr 
                85                  90                  95      


Met Val Leu Lys Met Val Ala Lys Leu Gln Asp Ile Arg Asn Phe Gln 
            100                 105                 110         


Ser His Ile Trp His Asp Asn Lys Val Leu Val Phe Asp Ala Asp Leu 
        115                 120                 125             


Val Gln Phe Ile Lys Asn Lys His Leu Glu Ala Ile Asp Ala Gln Arg 
    130                 135                 140                 


Gln Arg Phe Ser Lys Glu Thr Glu Val Tyr Glu Lys Glu Asn Arg Glu 
145                 150                 155                 160 


Leu Lys Lys Lys Lys Asn Lys Glu Leu Leu Phe Asp Ile His Asp Gly 
                165                 170                 175     


Leu Gly Tyr Ile Thr Gly Glu Gly Arg Asn Phe Phe Leu Ser Phe Phe 
            180                 185                 190         


Leu Thr Arg Gly Glu Met Thr Arg Phe Leu Lys Gln Arg Lys Gly Cys 
        195                 200                 205             


Lys Arg Asp Asp Thr Pro Glu Tyr Lys Ile Lys His Leu Val Tyr Arg 
    210                 215                 220                 


His Phe Thr His Arg Asp Gly Ala Thr Arg Thr His Tyr Gly Tyr Glu 
225                 230                 235                 240 


Asp Asn Met Leu Asp Gln Leu Pro Asp Lys Gln Glu Phe Leu Thr Thr 
                245                 250                 255     


Arg His Thr Tyr Arg Leu Ile Asn Tyr Leu Asn Asp Ile Pro Glu Glu 
            260                 265                 270         


Val Thr Asn Pro Glu Leu Phe Pro Leu Phe Asn Thr Ile Ser Asn Gly 
        275                 280                 285             


Ile Leu Ile Lys Glu Ser Val Gly Thr Tyr Ile Ala Phe Ile Asn Lys 
    290                 295                 300                 


Met Pro Leu Leu Ser Asp Phe Glu Phe Ser Glu Val Trp Gly Lys Asp 
305                 310                 315                 320 


Gly Lys Pro Tyr Thr Asn Leu Val Glu Phe Tyr His Lys Thr Gln Pro 
                325                 330                 335     


Gly Phe Lys Phe Arg Thr Asp Leu Asn Ser Phe His Lys Ile Ile Leu 
            340                 345                 350         


Asn Leu Ile Arg Asp Glu Asn Tyr Thr Gly Phe Phe Thr Thr Gln Leu 
        355                 360                 365             


Asn Leu Phe Met Ala His Arg Glu Glu Leu Ile Leu Val Ile Ser Lys 
    370                 375                 380                 


Pro Leu Ile Thr Pro Asn Asp Leu Leu Leu Ile Glu Glu His Tyr Arg 
385                 390                 395                 400 


Tyr Lys Leu Lys Ala Asn Asp Phe Val Arg Glu Lys Leu Gly Glu Trp 
                405                 410                 415     


Lys Glu Lys Ile Glu Lys Gly Lys Trp Glu Lys Ala Asn Glu Gln Lys 
            420                 425                 430         


Asp Lys Leu Ile Asn Leu Leu Gly Gly Val Ile Glu Ile Thr Phe Tyr 
        435                 440                 445             


Asp Phe Tyr Trp Gln Lys Asp Glu Lys Pro Arg Asn Glu Asn Arg Phe 
    450                 455                 460                 


Met Glu Phe Ala Ile Arg Phe Met Ala Asp Phe Asn Leu Leu Pro Asp 
465                 470                 475                 480 


Cys Glu Trp Glu Val Glu Pro Leu Gln Ile Glu Asn Asp Leu Ile Ala 
                485                 490                 495     


Asn Arg Thr Ala Thr Pro Asp Leu Lys Lys Ser Gly Ser Gln Phe Met 
            500                 505                 510         


Asn Gln Leu Thr Asp Asn Tyr Arg Leu Lys Phe Asn Asp Gly Gln Ile 
        515                 520                 525             


Ala Phe Arg Tyr Gln Asn Gln Val Phe Ile Met Gly His Lys Ala Val 
    530                 535                 540                 


Lys Asn Leu Leu Ile Ala Cys Phe Asp Gly Lys Glu Lys Met Leu Asn 
545                 550                 555                 560 


Gly Phe Met Pro Ala Leu Leu Ala Asp Leu Lys Lys Ile Thr Asn Glu 
                565                 570                 575     


His Ile Leu Lys Asn His Gln Ala Leu Asn Thr Leu Ser Leu Leu Asn 
            580                 585                 590         


Asn Asp Ser Ile Pro Ser Tyr Ile Ser Arg Gln Trp Gly Glu Ala Glu 
        595                 600                 605             


Pro Ile Thr Asp Met Lys Lys Lys Ala Ile Ala Arg Met Asp Tyr Ile 
    610                 615                 620                 


Thr Gln Gln Phe Glu Ala Leu Ile Glu Asn His His Tyr Leu Asn Arg 
625                 630                 635                 640 


Ala Asp Lys Asn Arg Gln Ile Met Arg Cys Tyr Lys Phe Phe Glu Trp 
                645                 650                 655     


Gln Tyr Pro Gln Asn Ser Gln Phe Lys Phe Leu Arg Arg Asn Glu Tyr 
            660                 665                 670         


His Arg Met Ser Ile Tyr His Tyr Cys Leu Asp Lys Glu Gln His Lys 
        675                 680                 685             


Tyr Asp Lys Lys Gly His Asn Tyr Leu Tyr Asn Arg Leu Ile Lys Glu 
    690                 695                 700                 


Ser His Asn Glu Ser Gly Asn Ile Glu Gln His Leu Pro Tyr Gln Ile 
705                 710                 715                 720 


Arg Thr Met Leu Asn Asp Ala Lys Asp Phe Asn Asp Tyr Phe Leu Arg 
                725                 730                 735     


Ile Leu Asn Ala Thr His Lys Ile Leu Thr Asp Trp Lys Asn Gln Leu 
            740                 745                 750         


Lys Gln Gly Arg Glu Pro Asn Asn Tyr Tyr Leu Ser Arg Leu Gly Phe 
        755                 760                 765             


Thr Gly Gly Leu Thr Gln Lys Val Val His Thr Arg Leu Leu Pro Phe 
    770                 775                 780                 


Ser Ile His Pro Gly Ile Pro Val Ser Phe Phe Tyr Arg Thr Glu Met 
785                 790                 795                 800 


Asn Gln Asn Pro Ser Phe Asn Leu Ser Ala Lys Val Trp Asn Ser Glu 
                805                 810                 815     


Ser Pro Phe Arg Val Gly Leu Lys Glu Ser Asn Tyr Gln Tyr Ala Lys 
            820                 825                 830         


Tyr Leu Gly Leu Phe Asn Glu Ile Lys Thr Gln Arg Lys Ile Ile Gly 
        835                 840                 845             


Lys Met Asn Gln Leu Ile Ala Glu Asp Ala Leu Leu Trp Gln Ile Ala 
    850                 855                 860                 


Lys Lys Tyr Leu Asp Lys Cys His Pro Lys Phe Ser Glu Ile Ile Asn 
865                 870                 875                 880 


Gln Gln Val Asn Gly Lys Gln Pro Leu Asn Val Lys Ala Ile His Asp 
                885                 890                 895     


Thr Glu Leu Thr Ile Asp Phe Pro Val Asp Lys Asn Leu Tyr Gln Val 
            900                 905                 910         


Val Val Lys Met Lys Gln Leu Asp Asp Phe Met Phe Ile Asp Ser Lys 
        915                 920                 925             


Pro Val Leu Glu Lys Thr Ile Arg Tyr Met Ile Lys Asn Ser Leu Arg 
    930                 935                 940                 


Asp Lys Glu Tyr Gln Gln Arg Val Phe Ile Glu Thr Asn Pro Gly Val 
945                 950                 955                 960 


Phe Lys Ile Pro Tyr Asn Glu Val Val Glu Ala Met Arg Thr Ile Asn 
                965                 970                 975     


His Gln Ala Leu Thr Trp Ala Arg Leu Leu Leu Asp Trp Glu Ser Lys 
            980                 985                 990         


Thr Val Lys Thr Ile Pro Glu Ala  Asp Lys Lys Ala Lys  Leu Gln Glu 
        995                 1000                 1005             


Ala Tyr  Asn Lys Arg Gln Pro  Ala Phe Phe Asn Phe  Asn Asp Ile 
    1010                 1015                 1020             


Cys Arg  Tyr Ala Asp Asp Gly  Lys Gln Leu Lys Asp  Leu Arg Asn 
    1025                 1030                 1035             


Lys Thr  Phe His Thr Glu Val  Pro Glu Thr Trp Thr  Tyr Asp Glu 
    1040                 1045                 1050             


Met Arg  Glu Asn Lys Thr Ile  Lys Met Val Leu Gly  Ile Asn Glu 
    1055                 1060                 1065             


Thr Thr  Phe Leu Lys Lys Asp  Tyr Ala Ile Glu Asn  Ala Arg Thr 
    1070                 1075                 1080             


Ile Glu  
    1085 


<210>  1832
<211>  1085
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1832

Met Lys Lys Glu Leu Asn Arg Glu Asp Val Phe Thr Gly Gly Lys Thr 
1               5                   10                  15      


Pro Glu Leu Thr Ile Tyr Tyr Asn Ile Ala Tyr Phe Arg Met Ala Gly 
            20                  25                  30          


Leu Ile Asn Ala Leu Cys Gly Asn Lys Leu Glu Arg Asp Lys Asp Ala 
        35                  40                  45              


Leu Glu Gln Phe Met Lys Ala Phe Ile Asn Gly Lys Gln Lys Leu Thr 
    50                  55                  60                  


Asp Met Gln Phe Val Lys Leu Cys Asp Tyr Leu Trp Lys Gly Tyr Lys 
65                  70                  75                  80  


Tyr Asp Lys Asn Arg Ser Glu Tyr Ser Leu Thr Glu Asn Asp Lys Thr 
                85                  90                  95      


Met Val Leu Lys Met Val Ala Lys Leu Gln Asp Ile Arg Asn Phe Gln 
            100                 105                 110         


Ser His Ile Trp His Asp Asn Lys Val Leu Val Phe Asp Ala Asp Leu 
        115                 120                 125             


Val Gln Phe Ile Lys Asn Lys His Leu Glu Ala Ile Asp Ala Gln Arg 
    130                 135                 140                 


Gln Arg Phe Ser Lys Glu Thr Glu Val Tyr Glu Lys Glu Asn Arg Glu 
145                 150                 155                 160 


Leu Lys Lys Lys Lys Asn Lys Glu Leu Leu Phe Asp Ile His Asp Gly 
                165                 170                 175     


Leu Gly Tyr Ile Thr Gly Glu Gly Arg Asn Phe Phe Leu Ser Phe Phe 
            180                 185                 190         


Leu Thr Arg Gly Glu Met Thr Arg Phe Leu Lys Gln Arg Lys Gly Cys 
        195                 200                 205             


Lys Arg Asp Asp Thr Pro Glu Tyr Lys Ile Lys His Leu Val Tyr Arg 
    210                 215                 220                 


His Phe Thr His Arg Asp Gly Ala Thr Arg Thr His Tyr Gly Tyr Glu 
225                 230                 235                 240 


Asp Asn Met Leu Asp Gln Leu Pro Asp Lys Gln Glu Phe Leu Thr Thr 
                245                 250                 255     


Arg His Thr Tyr Arg Leu Ile Asn Tyr Leu Asn Asp Ile Pro Glu Glu 
            260                 265                 270         


Val Thr Asn Pro Glu Leu Phe Pro Leu Phe Asn Thr Ile Ser Asn Gly 
        275                 280                 285             


Ile Leu Ile Lys Glu Ser Val Gly Thr Tyr Ile Ala Phe Ile Asn Lys 
    290                 295                 300                 


Met Pro Leu Leu Ser Asp Phe Glu Phe Ser Glu Val Trp Gly Lys Asp 
305                 310                 315                 320 


Gly Lys Pro Tyr Thr Asn Leu Val Glu Phe Tyr His Lys Thr Gln Pro 
                325                 330                 335     


Gly Phe Lys Phe Arg Thr Asp Leu Asn Ser Phe His Lys Ile Ile Leu 
            340                 345                 350         


Asn Leu Ile Arg Asp Glu Asn Tyr Thr Gly Phe Phe Thr Thr Gln Leu 
        355                 360                 365             


Asn Leu Phe Met Ala His Arg Glu Glu Leu Ile Leu Val Ile Ser Lys 
    370                 375                 380                 


Pro Leu Ile Thr Pro Asn Asp Leu Leu Leu Ile Glu Glu His Tyr Arg 
385                 390                 395                 400 


Tyr Lys Leu Lys Ala Asn Asp Phe Val Arg Glu Lys Leu Gly Glu Trp 
                405                 410                 415     


Lys Glu Lys Ile Glu Lys Gly Lys Trp Glu Lys Ala Asn Glu Gln Lys 
            420                 425                 430         


Asp Lys Leu Ile Asn Leu Leu Gly Gly Val Ile Glu Ile Thr Phe Tyr 
        435                 440                 445             


Asp Phe Tyr Trp Gln Lys Asp Glu Lys Pro Arg Asn Glu Asn Arg Phe 
    450                 455                 460                 


Met Glu Phe Ala Ile Arg Phe Met Ala Asp Phe Asn Leu Leu Pro Asp 
465                 470                 475                 480 


Cys Glu Trp Glu Val Glu Pro Leu Gln Ile Glu Asn Asp Leu Ile Ala 
                485                 490                 495     


Asn Arg Thr Ala Thr Pro Asp Leu Lys Lys Ser Gly Ser Gln Phe Met 
            500                 505                 510         


Asn Gln Leu Thr Asp Asn Tyr Arg Leu Lys Phe Asn Asp Gly Gln Ile 
        515                 520                 525             


Ala Phe Arg Tyr Gln Asn Gln Val Phe Ile Met Gly His Lys Ala Val 
    530                 535                 540                 


Lys Asn Leu Leu Ile Ala Cys Phe Asp Gly Lys Glu Lys Met Leu Asn 
545                 550                 555                 560 


Gly Phe Met Pro Ala Leu Leu Ala Asp Leu Lys Lys Ile Thr Asn Glu 
                565                 570                 575     


His Ile Leu Lys Asn His Gln Ala Leu Asn Thr Leu Ser Leu Leu Asn 
            580                 585                 590         


Asn Asp Ser Ile Pro Ser Tyr Ile Ser Arg Gln Trp Gly Glu Ala Glu 
        595                 600                 605             


Pro Ile Thr Asp Met Lys Lys Lys Ala Ile Ala Arg Met Asp Tyr Ile 
    610                 615                 620                 


Thr Gln Gln Phe Glu Ala Leu Ile Glu Asn His His Tyr Leu Asn Arg 
625                 630                 635                 640 


Ala Asp Lys Asn Arg Gln Ile Met Arg Cys Tyr Lys Phe Phe Glu Trp 
                645                 650                 655     


Gln Tyr Pro Gln Asn Ser Gln Phe Lys Phe Leu Arg Arg Asn Glu Tyr 
            660                 665                 670         


His Arg Met Ser Ile Tyr His Tyr Cys Leu Asp Lys Glu Gln His Lys 
        675                 680                 685             


Tyr Asp Lys Lys Gly His Asn Tyr Leu Tyr Asn Arg Leu Ile Lys Glu 
    690                 695                 700                 


Ser His Asn Glu Ser Gly Asn Ile Glu Gln His Leu Pro Tyr Gln Ile 
705                 710                 715                 720 


Arg Thr Met Leu Asn Asp Ala Lys Asp Phe Asn Asp Tyr Phe Leu Arg 
                725                 730                 735     


Ile Leu Asn Ala Thr His Lys Ile Leu Thr Asp Trp Lys Asn Gln Leu 
            740                 745                 750         


Lys Gln Gly Arg Glu Pro Asn Asn Tyr Tyr Leu Ser Arg Leu Gly Phe 
        755                 760                 765             


Thr Gly Gly Leu Thr Gln Lys Val Val His Thr Arg Leu Leu Pro Phe 
    770                 775                 780                 


Ser Ile His Pro Gly Ile Pro Val Ser Phe Phe Tyr Arg Thr Glu Met 
785                 790                 795                 800 


Asn Gln Asn Pro Ser Phe Asn Leu Ser Ala Lys Val Trp Asn Ser Glu 
                805                 810                 815     


Ser Pro Phe Arg Val Gly Leu Lys Glu Ser Asn Tyr Gln Tyr Ala Lys 
            820                 825                 830         


Tyr Leu Gly Leu Phe Asn Glu Ile Lys Thr Gln Arg Lys Ile Ile Gly 
        835                 840                 845             


Lys Met Asn Gln Leu Ile Ala Glu Asp Ala Leu Leu Trp Gln Ile Ala 
    850                 855                 860                 


Lys Lys Tyr Leu Asp Lys Cys His Pro Lys Phe Ser Glu Ile Ile Asn 
865                 870                 875                 880 


Gln Gln Val Asn Gly Lys Gln Pro Leu Asn Val Lys Ala Ile His Asp 
                885                 890                 895     


Thr Glu Leu Thr Ile Asp Phe Pro Val Asp Lys Asn Leu Tyr Gln Val 
            900                 905                 910         


Val Val Lys Met Lys Gln Leu Asp Asp Phe Met Phe Ile Asp Ser Lys 
        915                 920                 925             


Pro Val Leu Glu Lys Thr Ile Arg Tyr Met Ile Lys Asn Ser Leu Arg 
    930                 935                 940                 


Asp Lys Glu Tyr Gln Gln Arg Val Phe Ile Glu Thr Asn Pro Gly Val 
945                 950                 955                 960 


Phe Lys Ile Pro Tyr Asn Glu Val Val Glu Ala Met Arg Thr Ile Asn 
                965                 970                 975     


His Gln Ala Leu Thr Trp Ala Arg Leu Leu Leu Asp Trp Glu Ser Lys 
            980                 985                 990         


Thr Val Lys Thr Ile Pro Glu Ala  Asp Lys Lys Ala Lys  Leu Gln Glu 
        995                 1000                 1005             


Ala Tyr  Asn Lys Arg Gln Pro  Ala Phe Phe Asn Phe  Asn Asp Ile 
    1010                 1015                 1020             


Cys Arg  Tyr Ala Asp Asp Gly  Lys Gln Leu Lys Asp  Leu Arg Asn 
    1025                 1030                 1035             


Lys Thr  Phe His Thr Glu Val  Pro Glu Thr Trp Thr  Tyr Asp Glu 
    1040                 1045                 1050             


Met Arg  Glu Asn Lys Thr Ile  Lys Met Val Leu Gly  Ile Asn Glu 
    1055                 1060                 1065             


Thr Thr  Phe Leu Lys Lys Asp  Tyr Ala Ile Glu Asn  Ala Arg Thr 
    1070                 1075                 1080             


Ile Glu  
    1085 


<210>  1833
<211>  1164
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1833

Met Thr Ala Thr Asn Gly Leu Gly Lys Gly Ile Ser Tyr His His His 
1               5                   10                  15      


Leu Tyr Ala Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Asp 
            20                  25                  30          


Asp Asn Ile Asp Gln Val Lys Gln Leu Phe Asp Thr Arg Phe Gly Glu 
        35                  40                  45              


Lys Asn Ala Asp Arg Phe Phe Ser Thr Lys Asn Asn His Leu Ile Ala 
    50                  55                  60                  


Tyr Asp Asp Trp Glu Lys Gly Ile Asp Phe Leu Lys Gln Tyr Leu Pro 
65                  70                  75                  80  


Val Val His Tyr Leu Ala Leu Pro Val Asn His Glu Lys Phe Ser Asn 
                85                  90                  95      


Leu Thr Asp Lys Glu Lys Gly Arg Arg Asp Tyr Phe Thr Ile His Phe 
            100                 105                 110         


Asn Leu Leu Thr Ser Thr Ile His Asp Cys Arg Asn Phe Tyr Thr His 
        115                 120                 125             


Tyr Tyr His Asp Pro Ile Thr Val Gln Asn Asp Leu Phe Gln Leu Leu 
    130                 135                 140                 


Asp Glu Leu Phe Ile Leu Val Cys Arg Asp Val Arg Lys His Arg Ile 
145                 150                 155                 160 


Lys Thr Asp Lys Thr Gly Trp Leu Leu Lys Arg Thr Leu Gln Asn Glu 
                165                 170                 175     


Leu Gln Ile Leu Thr Lys His Lys Lys His Thr Leu Glu Lys Gln Lys 
            180                 185                 190         


Lys Glu Gly Lys Lys Val Asn Leu Asp Ala Glu Ala Ile Glu Asn Ala 
        195                 200                 205             


Val Met Asn Asp Ala Phe Lys His Leu Arg Tyr Thr Asp Lys Glu Asp 
    210                 215                 220                 


Asn Lys Gly Asn Ile Lys Lys Phe Leu Val Lys Asp Gln Tyr Lys Ser 
225                 230                 235                 240 


Ala Tyr Asn Arg Gln Glu Pro Ser Glu Asn Gly Ile Cys Leu Ser Arg 
                245                 250                 255     


Ser Gly Leu Leu Phe Leu Cys Ser Met Phe Leu Ser Arg Lys Ala Gly 
            260                 265                 270         


Glu Asp Met Arg Ala Arg Val Ser Gly Phe Lys Glu Lys Phe Val Tyr 
        275                 280                 285             


Arg Thr Glu Glu Glu Ile Thr Asp Lys Asn Asn Ser Leu Arg Ser Met 
    290                 295                 300                 


Val Thr Gln Trp Val Phe Ser His Leu Ala Phe Lys Asp Ile Lys Gln 
305                 310                 315                 320 


Arg Ile Thr Thr Asn Leu Asp Arg Glu Thr Leu Phe Val Gln Ile Val 
                325                 330                 335     


Asp Tyr Leu Ser Lys Val Pro Asp Glu Leu Tyr Gln Val Phe Ser Asn 
            340                 345                 350         


Thr Gln Lys Leu Asp Phe Leu Glu Asp Ile Asn Glu Tyr Ile Lys Glu 
        355                 360                 365             


Gly Asn Lys Thr Glu Ser Leu Ile Gln Ser Thr Val Ala His Pro Val 
    370                 375                 380                 


Ile Arg Lys Arg Tyr Glu Asn Gln Phe Asn Tyr Phe Val Leu Arg Tyr 
385                 390                 395                 400 


Leu Asp Glu Phe Val Glu Phe Pro Ser Leu Arg Phe Gln Ile Asn Thr 
                405                 410                 415     


Gly Phe Tyr Thr His Asp Gln Arg Glu Lys Thr Ile Glu Gly Thr Glu 
            420                 425                 430         


Tyr Leu Thr Asp Arg Lys Ile Lys Glu Lys Ile Lys Val Phe Gly Lys 
        435                 440                 445             


Leu Ser Glu Val Thr Thr Gln Lys Asn Glu Phe Leu Val Lys Asn Thr 
    450                 455                 460                 


Asp Leu Gln Gly Trp Glu Ala Tyr Pro Gly Pro Ser Tyr Asn Val Asn 
465                 470                 475                 480 


Asn Asn Asn Ile Pro Val Phe Ile Asn Met Gln Asn Asn Ala Val Asn 
                485                 490                 495     


Gly Ser Lys Gln Trp Tyr Ser Lys Ile Asn Phe Lys Ile Arg Asn Glu 
            500                 505                 510         


Arg Asn Leu Lys Gln Ser Pro Arg Thr Glu Asp Lys Lys Gln Lys Ser 
        515                 520                 525             


Ala Ile Ala Asp Met Leu Lys Ile Asn Gly Glu Met Asp Leu Arg Tyr 
    530                 535                 540                 


Glu Glu Pro Thr Ala Ile Leu Cys Leu Lys Glu Leu Pro Ser Leu Leu 
545                 550                 555                 560 


Tyr Glu Leu Leu Tyr Thr Lys Ala Ser Pro Lys Glu Ile Glu Glu His 
                565                 570                 575     


Leu Leu Lys Lys Ile Ile Gly His Leu Asp Thr Ile Glu Lys Tyr Ala 
            580                 585                 590         


His His Thr Asp Ser Ser Leu Gln Gly Met Pro Arg Lys Leu Lys Lys 
        595                 600                 605             


Ser Gly Glu Glu Ser Ser Ile Asn Tyr Lys Lys Leu Arg Glu Val Ile 
    610                 615                 620                 


Val Asn Glu Leu Lys Val Ile Thr Glu Lys Gln Asp Phe Leu Lys Glu 
625                 630                 635                 640 


Lys Gln Lys Asp Lys Lys Val Asn Lys Arg Leu Tyr Leu Leu Asn Asn 
                645                 650                 655     


Arg Glu Met Gly Lys Glu Ala Thr Trp Leu Ala Ser Asp Leu Ile Arg 
            660                 665                 670         


Phe Met Pro Glu Thr Ala Arg Lys Gln Trp Lys Gly Tyr His His Ser 
        675                 680                 685             


Gln Leu Gln Gln Thr Leu Ala Phe Tyr Gln Gln Lys Arg Lys Glu Ala 
    690                 695                 700                 


Leu Ser Leu Ile Gly Gln Phe Trp Asp Phe Asn Thr Gly Pro Tyr Trp 
705                 710                 715                 720 


Gly Asp Lys Leu Lys Lys Ala Phe Glu Gln Thr Thr Phe Glu Asp Phe 
                725                 730                 735     


Tyr Phe Glu Tyr Leu Lys Met Arg Gln Ala Ile Leu Asn Asn Phe Leu 
            740                 745                 750         


Glu Asn Val Ser Ser Ser Gln Asn Gln Pro Asn Leu Ala Lys Lys Ala 
        755                 760                 765             


Leu Lys Asp Cys Trp Ile Ile Phe His Lys Arg His Phe Ile Ile Arg 
    770                 775                 780                 


Pro Ala Lys Glu Gln Ile Ser Ser Leu Leu Ala Gln Pro Val Val Leu 
785                 790                 795                 800 


Pro Arg Gly Leu Phe Asp Asn Lys Pro Thr Tyr Ile Lys Asp Val Lys 
                805                 810                 815     


Leu Glu Asp Ala Pro Glu Lys Phe Ala Asn Trp Tyr Arg Tyr Thr Tyr 
            820                 825                 830         


Asn Asp Tyr Pro Met Gln Arg Phe Tyr Ser Phe Asp Arg Asp Tyr Thr 
        835                 840                 845             


Ser Leu Tyr Glu Glu Phe Gln Ser Asn Lys Asp Val Ile Leu Asn Lys 
    850                 855                 860                 


Lys Arg Leu Thr Lys Ser Glu Gln Glu Ala Leu Leu Lys Lys Lys Gln 
865                 870                 875                 880 


Asp Leu Lys Ile Lys Asp Ile Arg Thr Gln Asp Leu Phe Leu Lys Leu 
                885                 890                 895     


Ile Ala Asp Lys Leu Phe Glu Asp Ile Phe Asp Gln Lys Ala Asp Phe 
            900                 905                 910         


Thr Leu Glu Asp Ile Tyr Gln Thr Arg Glu Glu Arg Met Gln Asn Gly 
        915                 920                 925             


Glu Gln Ala Leu Gln Gln Ser Glu Arg Ala Pro Gly Asp Asp Phe Glu 
    930                 935                 940                 


Asn Ile Tyr Asn Glu Ser Phe Val Leu Asn Lys Thr Val Pro Phe Ile 
945                 950                 955                 960 


Gln Lys Gln Ile His Glu Pro Thr Val Lys Ile Lys Asp Leu Gly Lys 
                965                 970                 975     


Phe Lys Arg Phe Leu Phe Asp Asn Lys Val Lys Ala Leu Phe Ser Tyr 
            980                 985                 990         


Glu Pro Asn Arg Val Trp Ser Ile  Gln Glu Leu Glu Asn  Glu Leu Thr 
        995                 1000                 1005             


Leu Leu  Pro Thr Ser Tyr Glu  Val Ile Arg Arg Val  Ser Leu Leu 
    1010                 1015                 1020             


Lys Ala  Ile Gln Glu Phe Glu  Lys Tyr Ile Met Glu  Cys Trp Gly 
    1025                 1030                 1035             


Asp Ser  Asp Thr Thr Lys Leu  Asp Gln Lys Asp Lys  Lys Ser Gly 
    1040                 1045                 1050             


Lys Tyr  Asn Pro Ser Phe Lys  Lys Tyr Ile Phe Asn  Gly Val Leu 
    1055                 1060                 1065             


Asp Lys  Phe Arg Leu Ala Asn  Ala Glu Asn Ile Lys  His Ile Ile 
    1070                 1075                 1080             


Asp Tyr  Lys Lys Phe Glu Glu  Leu Val Asp Asp Pro  Gln Leu Lys 
    1085                 1090                 1095             


Ser Phe  Glu Glu Ile Val Arg  Lys Ala Tyr Ile Leu  Thr Ile Ile 
    1100                 1105                 1110             


Arg Asn  Lys Ile Ala His Asn  Gln Leu Pro Asp Lys  Ala Asn Met 
    1115                 1120                 1125             


Asp Phe  Ile Gln Gly Met Tyr  Pro Lys Glu Pro Gln  Asp Ser Tyr 
    1130                 1135                 1140             


Ser Gln  Tyr Leu Leu Arg Val  Thr Gln Leu Ile Ile  Asp Glu Met 
    1145                 1150                 1155             


Val Leu  Leu Met Lys Ile 
    1160                 


<210>  1834
<211>  1141
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1834

Met Thr Gln Thr Ala Thr Thr Asn Ser Gly Thr Leu Ala Asp Asp Lys 
1               5                   10                  15      


Gln Thr Tyr Tyr Tyr His Phe Leu Lys Ser Asp Lys Phe Phe Phe Gly 
            20                  25                  30          


Ser Phe Phe Asn Leu Ala Asp Asn Asn Leu Lys Ala Thr Phe Asn Asp 
        35                  40                  45              


Phe Glu Lys Arg Leu Gly Ile Lys Ser Ala Asn Gly Leu Val Gln Lys 
    50                  55                  60                  


Val Glu Gln Tyr Phe Pro Asp Asn Leu Leu Leu Ser Glu Phe Glu Arg 
65                  70                  75                  80  


Arg Thr Glu Leu Leu Thr Glu Tyr Leu Pro Ile Val His Lys Leu Arg 
                85                  90                  95      


Lys Ile Asn Lys Glu Ser Ala Glu Pro Asp Arg Ser Tyr Phe Arg Asp 
            100                 105                 110         


Asn Leu Lys Met Leu Ile Lys Ala Val Asp His Leu Arg Asn Phe Tyr 
        115                 120                 125             


Thr His Tyr Tyr His Lys Ser Ile Ile Phe Asp Glu Arg Leu Phe Glu 
    130                 135                 140                 


Phe Leu Asn Gly Ala Leu Leu Asn Val Cys Phe Asp Val Lys Lys Lys 
145                 150                 155                 160 


Arg Met Lys Ser Asp Thr Asn Lys Ala Phe Leu Lys Lys His Phe Glu 
                165                 170                 175     


Glu Asn Phe Ile Asn Lys Ser Lys Asp Lys Ile Lys Glu Ala Phe Asp 
            180                 185                 190         


Glu Ala Phe Ser His Leu Lys Val Ser Asn Asp Gly Lys Lys Phe Ser 
        195                 200                 205             


Leu Thr Lys Phe Tyr Gln Ala Lys Leu Ser His Lys Gln Lys Phe Ser 
    210                 215                 220                 


Val Lys Asn Asp Leu Ile Phe Asp Ile Thr Asn Ser Asp Phe Val Phe 
225                 230                 235                 240 


Leu Ser Asn Ser Gly Leu Leu Phe Leu Leu Ser Phe Phe Leu Arg Arg 
                245                 250                 255     


Glu Glu Gln Glu Gln Leu Leu Ser Lys Met Glu Gly Phe Lys Asn Gln 
            260                 265                 270         


Asn Glu Leu Asn Phe Ile Ala Thr Arg Trp Val Phe Thr His Lys Cys 
        275                 280                 285             


Phe Lys Gly Leu Lys Lys Thr Ile Lys Ser Ser Tyr Asp Lys Glu Thr 
    290                 295                 300                 


Leu Leu Met Gln Met Val Asp Glu Leu Ser Lys Cys Pro Asp Val Leu 
305                 310                 315                 320 


Tyr Lys Asn Leu Ser Asp Lys Gln Lys Gln Glu Phe Val Val Asp Val 
                325                 330                 335     


Asn Glu Phe Tyr Gln Glu Ala Lys Glu Gln Asn Glu Glu Asn Lys Leu 
            340                 345                 350         


Val Ser His Thr Ile Ile Arg Lys Arg Tyr Glu Asp Lys Phe Ala Tyr 
        355                 360                 365             


Phe Ala Leu Arg Phe Leu Asp Glu Phe Ala Asn Phe Pro Thr Leu Arg 
    370                 375                 380                 


Phe Gln Val Val Val Gly Asn Tyr Leu Gln Asn Glu Gln Glu Lys Gln 
385                 390                 395                 400 


Ile Lys Asn Thr Thr Thr Val Leu Lys Thr Asn Arg Gln Ile Lys Glu 
                405                 410                 415     


Arg Ile Lys Met Phe Gly Lys Leu Ser Thr Leu Ser Ser Lys Lys Ala 
            420                 425                 430         


Ala Tyr Phe Lys Ala Ile Leu Glu Asp Arg Thr Leu Thr Ala Glu Glu 
        435                 440                 445             


Lys Gly Leu Asp Pro Lys Trp Glu Ile Phe Pro Asn Pro Ser Tyr Gly 
    450                 455                 460                 


Phe Lys Gly Asn Asn Ile Pro Ile Tyr Ile Asn Lys Lys Gly Phe Lys 
465                 470                 475                 480 


Asn Met Leu Ser Val Asp Glu Ala Lys Val Arg Thr Asn Lys Asp Arg 
                485                 490                 495     


Ala Ala Lys Lys Asp Ile Ile Glu Lys Ile Phe Gly Lys Asp Asn Tyr 
            500                 505                 510         


Tyr Gly Lys Pro Ile Ala Tyr Leu Ser Leu Asn Glu Leu Pro Ala Leu 
        515                 520                 525             


Leu Tyr Glu Phe Leu Val Asn Gly Lys Asn Gly Ala Asp Ile Glu Asn 
    530                 535                 540                 


Ile Ile Phe Asn Lys Ile Lys Gln Gln Val Val Ala Ile Lys Ala Ala 
545                 550                 555                 560 


Asp Lys Thr Asn Lys Gly Ile Pro Asn Lys Leu Arg Lys Ala Lys Glu 
                565                 570                 575     


Glu Asn Asp Tyr Asp Leu Asn Lys Leu Lys Gly Asn Ile Lys Asp Gln 
            580                 585                 590         


Ile Asp Glu Cys Asn Glu Lys Ile His Phe Ile Arg Thr Cys Arg Ala 
        595                 600                 605             


Ala Phe Asp Pro Asn Lys Thr Lys His Phe Phe Thr Leu Lys Gln Leu 
    610                 615                 620                 


Gly Asp Glu Ala Thr Trp Leu Ala Asp Asp Ile Lys Arg Phe Met Leu 
625                 630                 635                 640 


Pro Glu Ala Arg Lys Asn Trp Lys Ala Tyr Glu His Ser Glu Phe Gln 
                645                 650                 655     


Arg Leu Leu Ala Phe Tyr Lys Arg Phe Arg Lys Asp Ala Arg Gln Leu 
            660                 665                 670         


Leu Lys Asn Lys Trp Thr Met Asn Asp Thr Phe Gly Glu Met Val Lys 
        675                 680                 685             


Arg Cys Phe Ser Gln Val Glu Phe Asp Gln Phe Tyr Glu Met Tyr Leu 
    690                 695                 700                 


Ile Asp Lys Ile Glu Gln Leu Glu Val Tyr Lys Asn Gln Leu Asp Gly 
705                 710                 715                 720 


Glu Ala Ile Gln Ser His Pro Lys Leu Leu Lys Lys Val Leu Lys Glu 
                725                 730                 735     


Ile Phe Arg Tyr Phe Asn Glu Arg Leu Tyr Leu Ile Lys Pro Ala Gly 
            740                 745                 750         


Lys Gln Ile Glu Glu Leu Leu Lys His Pro Ile Asn Leu Pro Arg Gly 
        755                 760                 765             


Ile Phe Asp Asn Arg Pro Thr Tyr Ile Glu Asn Ala Asn His Thr Asp 
    770                 775                 780                 


His Lys Asp Gln Tyr Ala Ala Trp Phe Leu His Ile Thr Lys Asn Glu 
785                 790                 795                 800 


Asn Glu Leu Gln Gln Phe Tyr Ser Phe Ala Trp Asn Ile Asn Asn Asp 
                805                 810                 815     


Lys Thr Leu Asp Tyr Glu Lys Leu Thr Lys Glu Lys Met Lys Arg Leu 
            820                 825                 830         


Glu Lys Lys Arg Lys Arg Gln Gly Lys Thr Asn Gln Asn Phe Ser Gln 
        835                 840                 845             


Asn Asn Ser Ile Asn Phe Asn Asn Leu Lys Glu Lys Ile Lys Ile Arg 
    850                 855                 860                 


Leu Gln Lys Asp Ala Lys Ala Ala Ile Asn Lys Gln Ile Arg Ser Asp 
865                 870                 875                 880 


Val Phe Ile Lys Ala Met Ala Asp Tyr Val Phe Glu Lys Thr Phe Asp 
                885                 890                 895     


Lys Pro Tyr Gln Ile Pro Leu Asn Glu Ile Tyr Gln Asn Lys Ala Gln 
            900                 905                 910         


Lys Glu Gln Met Arg Asn Glu Ala Ala Ala Gln Gln Ser Arg Ala Glu 
        915                 920                 925             


Gly Asp Lys Ser Ser Asn Ile Tyr Asn Glu Thr Phe Ile Trp Asn Lys 
    930                 935                 940                 


Val Ile Ser Tyr Ser Ile Phe Gly Gly Lys Ile Lys Glu Glu Lys Leu 
945                 950                 955                 960 


Lys Leu Lys Asp Ile Gly Lys Phe Arg Ala Leu Glu Gln Asn Pro Lys 
                965                 970                 975     


Val Lys Ala Ile Val Thr Tyr Pro His Asn Asp Asp Trp Ser Lys Thr 
            980                 985                 990         


Glu Ile Glu Lys Glu Leu Thr Asn  Tyr Glu Arg Ile Arg  Ser Glu Thr 
        995                 1000                 1005             


Leu Leu  Lys Ser Val Gln Glu  Ile Glu Lys Lys Val  Leu Gln Lys 
    1010                 1015                 1020             


Leu Gln  Thr Gly Thr Val His  Pro Lys Ile Leu Glu  His Lys Gly 
    1025                 1030                 1035             


Asn Pro  Gln Phe Arg Lys Tyr  Val Val Glu Gly Phe  Leu Lys Asp 
    1040                 1045                 1050             


Met Ile  Ala Glu Pro Glu Leu  Thr Phe Phe Asn Asn  Asn Lys Thr 
    1055                 1060                 1065             


Ile Asp  Asn Phe Ser Ile Ser  Glu Val Glu Glu Gln  Ala Leu Leu 
    1070                 1075                 1080             


Ile Gln  Gln Ala Phe Tyr Leu  Ile Leu Ile Arg Asn  Lys Phe Ala 
    1085                 1090                 1095             


His Asn  Gln Leu Pro Asn Val  Ala Phe Phe Glu Ala  Met Ile Asn 
    1100                 1105                 1110             


Ile Ser  Gly Ile Glu Lys Arg  Asn Asp Asn Phe Ala  Ala Gln Leu 
    1115                 1120                 1125             


Asn Gln  Ile Phe Asp Thr Phe  Lys Ala Glu Ile Ile  Lys 
    1130                 1135                 1140     


<210>  1835
<211>  1123
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1835

Met Ile Thr Glu Gln Ala Lys Val Glu Glu Ser Thr Lys Ser Val Tyr 
1               5                   10                  15      


Gln Asn Pro Gly Tyr Phe Gly Ala Phe Leu Asn Met Ala Val Leu Asn 
            20                  25                  30          


Val Phe Ala Ile Ser Asn Gln Ile Val Lys Thr Phe Lys Glu Leu Asn 
        35                  40                  45              


Gly Val Glu Leu Lys Asn Asp Ser Asp Ile Lys Cys Ser Asp Lys Asn 
    50                  55                  60                  


Leu Leu Leu Gln Ile Phe Asn Asn Ala Asn Leu Pro Ser Glu Ile Lys 
65                  70                  75                  80  


Trp Asn Val Phe Asn Tyr Leu Tyr Lys Arg Gln His Phe Pro Val Leu 
                85                  90                  95      


Lys Tyr Phe Leu Ser Cys Tyr His Asp Asp Gly Asn Gln Arg Phe Tyr 
            100                 105                 110         


Asn Asn Glu Thr Lys Leu Phe Glu Arg Thr His Gln Phe Leu Gln Glu 
        115                 120                 125             


Ser Phe Asn Ala Leu Val Ala Leu Arg Asn Asp Phe Thr His Tyr Ile 
    130                 135                 140                 


Ala Ile Asp Asp Gln Gly Asn Glu Val Glu Lys Lys Tyr Glu Val His 
145                 150                 155                 160 


Gln Asn Leu Ala Asn Leu Met Gln Asp Glu Leu Leu His Ala Ser Ile 
                165                 170                 175     


Asn Phe Ser Lys Thr Arg Phe Glu Gln Thr Gln Ile Glu Glu Asp Phe 
            180                 185                 190         


Lys Phe Leu Gln His Val Lys Leu Ile Glu Asp Asn Val Pro Lys Leu 
        195                 200                 205             


Thr Glu Gln Gly Leu Tyr Phe Phe Thr Ser Leu Phe Leu Glu Arg Gly 
    210                 215                 220                 


Lys Thr Tyr Leu Phe Leu Lys Lys Leu Thr Gly Phe Lys Asn Glu Thr 
225                 230                 235                 240 


Thr Pro Ser Phe Arg Ala Thr Leu Lys Val Phe Ser Ala Phe Cys Leu 
                245                 250                 255     


Lys Leu Pro Lys Ala Lys Ile Gln Asn Asp Asp Tyr Lys Gln Ser Leu 
            260                 265                 270         


Leu Met Glu Met Leu Pro Glu Leu Ala Lys Cys Pro Ala Ile Leu Tyr 
        275                 280                 285             


Asn Arg Leu Ser Glu Asp Asp Lys Gln Lys Phe Lys Thr Lys Ile Ser 
    290                 295                 300                 


Asn Glu Ala Arg Lys Asn Ile Glu Leu Asn Ser Thr Asp Tyr Lys Asn 
305                 310                 315                 320 


Ile Asp Ile Gln Gln Leu Glu Leu Glu Ile Asn Asp Leu Val Ser Gln 
                325                 330                 335     


Lys Arg Arg Ser Asp Arg Phe His Tyr Phe Ala Leu Arg Phe Leu Asp 
            340                 345                 350         


Glu Leu Asp Val Phe Lys Asn Ile Lys Phe Gln Ile Lys Leu Gly Arg 
        355                 360                 365             


Leu Met Phe Ser Glu Asp Asp Ile Arg Asp Lys Glu Ile Leu Gly Glu 
    370                 375                 380                 


Ile Gln Ala Arg Lys Ile Thr Lys Thr Val Cys Ala Phe Gly Lys Leu 
385                 390                 395                 400 


Ser Glu Leu Glu Lys Met Ala Glu Asn Gln Leu Val Ser Gln Leu Lys 
                405                 410                 415     


Gly His Thr Asn Glu Trp Lys Phe Asp Gln Phe Ala Pro His Tyr Asn 
            420                 425                 430         


Met Gln His Asn Lys Ile Ala Phe Cys Phe Ser Glu Gln Val Lys Tyr 
        435                 440                 445             


Pro Val Leu Lys Lys Glu Asp Glu Lys Ala Asn Gln Pro Asp Gly Tyr 
    450                 455                 460                 


Leu Ser Leu His Ala Leu Pro Lys Leu Ile Leu Thr Ser Ile Leu Glu 
465                 470                 475                 480 


Ser Asp Lys Leu Glu Thr Leu Ile Lys Glu Phe Phe Lys Asn Asn Ser 
                485                 490                 495     


Asp Thr Ile Leu Asn Val Leu Thr Leu Lys Glu Ile Lys Asp Gln Leu 
            500                 505                 510         


Asn Phe Gly Ser Asp Pro Lys Glu Leu Thr Arg Lys Leu Ile Asp Tyr 
        515                 520                 525             


Asn Lys Asn Pro Arg Ile Leu Ser Gly Lys Glu Lys Glu Glu Lys Arg 
    530                 535                 540                 


Asp Leu Ala Glu Arg Met Glu Lys Glu Ile Asn Asp Arg Glu Asp Tyr 
545                 550                 555                 560 


Ala Ile Lys Met Lys Ser Arg Asn Lys Lys Leu Asn Val Ala Leu Gln 
                565                 570                 575     


Asn Tyr Asn Leu His His Asn Gln Leu Pro Ser Ile Val Lys Asp Tyr 
            580                 585                 590         


Leu Leu Asn Ile Gln Asn Pro Ser Leu Ala Leu Lys Ile Asn Thr Tyr 
        595                 600                 605             


Leu Lys Ala Glu Lys Leu Thr Phe Gln Gln Ser Leu Lys Lys Ile Lys 
    610                 615                 620                 


Lys Gln Gln Glu Leu Asn His Thr Ile Lys Leu Gly Glu Leu Ala Thr 
625                 630                 635                 640 


Ile Ile Thr Arg Asp Met Met Asn Met Leu Val Asp Thr Ala Leu Lys 
                645                 650                 655     


Ser Lys Leu Thr Pro Pro Tyr Thr Asn Lys Ile Gln Asn Ala Ile Ala 
            660                 665                 670         


His Phe Gly Leu Lys Lys Asn Glu Leu Ile Asn Met Leu Thr Glu Trp 
        675                 680                 685             


Lys Ile Leu Asp Asn Arg Ala Gly His Val Phe Leu Gln Lys Asn His 
    690                 695                 700                 


Ile Lys Asn Ser Lys Gly Val Val Asp Phe Tyr Glu Asn Tyr Val Glu 
705                 710                 715                 720 


Gln Lys Ile Lys Tyr Ile Asp Asn Ile Lys Ala Lys Thr Lys Asn Leu 
                725                 730                 735     


Phe Gly Leu Lys Pro Asp Ala Asn Val Ser Asn Gln Leu Pro Tyr Lys 
            740                 745                 750         


Tyr Arg Lys Leu Thr Glu Lys Tyr Gln Lys Pro Ala Ile Lys Asp Tyr 
        755                 760                 765             


Val Lys Gln Lys Gln Lys Val Pro Val Asn Leu Pro Leu Asn Leu Phe 
    770                 775                 780                 


Asp Glu Val Leu Phe Ser Ala Leu Arg Ser Lys Val Asn Thr Ser Lys 
785                 790                 795                 800 


Thr Gly Leu Asn Asn Leu Leu Ala Ala Tyr Leu Lys Asp Asp Ser Gln 
                805                 810                 815     


Thr Phe Tyr Ser Phe Asn Arg Leu Tyr Asn Ile Asn Lys Glu Pro Thr 
            820                 825                 830         


Thr Val Asp Val Asn Ser Lys Ser Leu Lys Glu Ile Lys Ile Glu Phe 
        835                 840                 845             


Gly Lys Pro Val Phe Glu Asn Glu Lys Lys Ile Arg Tyr Gln Gln Met 
    850                 855                 860                 


Ile Asp Arg Val Met Lys Met Met Cys Ile Glu Leu Met Gln Lys Gln 
865                 870                 875                 880 


Asp Thr Asp Leu Thr Leu Gly Val Ser Gln Leu Glu Leu Ala Lys Leu 
                885                 890                 895     


Ser Asn Ala Thr Pro Asp Lys Asn Phe Leu Asn Ala Pro Val Ser Phe 
            900                 905                 910         


Lys Arg Thr Val Asn Ala Asp Lys Glu Leu Ile Ala Glu Asp Asn Glu 
        915                 920                 925             


Glu Thr Lys Gln Lys Val Ala Glu Ser Ile Arg Ala Tyr Lys Ala Gly 
    930                 935                 940                 


Thr Lys Glu Val Ile Glu His Trp Tyr Ser Trp Thr Val Lys Asp Tyr 
945                 950                 955                 960 


Gly Arg Phe Thr Arg Leu Leu Val Asp Arg Arg Leu Glu Asn Leu Leu 
                965                 970                 975     


Lys His Phe Glu Gly Asp Ala Ile Pro Phe Ser Ile Ile Lys Tyr Glu 
            980                 985                 990         


Leu Asp Asn Tyr Asp Lys Tyr Trp  His Lys Ile Leu Asp  Glu Leu Leu 
        995                 1000                 1005             


Lys Val  Glu Lys Ala Ile Phe  Glu Lys Asp Gly Glu  Arg Ile Lys 
    1010                 1015                 1020             


Ala Leu  Gln Leu Gly Ser Lys  Tyr Glu His Val Gln  Phe Gly Lys 
    1025                 1030                 1035             


Tyr Val  Lys Trp Leu Lys Glu  Lys Ser Ile Asn Tyr  Asp Lys Lys 
    1040                 1045                 1050             


Leu Phe  Leu Asn Val Arg Asn  Lys Phe Ser His Ser  Gln Phe Leu 
    1055                 1060                 1065             


Glu Ile  Asp Lys Val Gly Leu  Ser Lys Ile Ser Glu  Gln Ile Thr 
    1070                 1075                 1080             


Tyr Asn  Phe Asn Glu Asn Tyr  Leu Thr Gly Asp Trp  Ile Asn Thr 
    1085                 1090                 1095             


Asn Tyr  Glu Ser Ile Ala Ser  Lys Val Tyr Thr Lys  Phe Lys Thr 
    1100                 1105                 1110             


Glu Ile  Asp Glu Ile Leu Lys  Gln Ile Ala 
    1115                 1120             


<210>  1836
<211>  1224
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1836

Met Glu Asn Lys Thr Ser Leu Gly Asn Asn Ile Tyr Tyr Asn Pro Phe 
1               5                   10                  15      


Lys Pro Gln Asp Lys Ser Tyr Phe Ser Gly Tyr Leu Asn Val Ala Met 
            20                  25                  30          


Glu Asn Ile Asp Ser Val Phe Arg Glu Leu Gly Lys Arg Leu Lys Gly 
        35                  40                  45              


Lys Glu Tyr Thr Trp Glu Asn Phe Phe Asp Ala Ile Phe Lys Glu Asn 
    50                  55                  60                  


Ile Ser Leu Val Glu Tyr Glu Arg Tyr Val Lys Leu Leu Ser Asp Tyr 
65                  70                  75                  80  


Phe Pro Met Ala Arg Leu Leu Asp Lys Lys Glu Ala Pro Ile Lys Glu 
                85                  90                  95      


Arg Lys Glu Asn Phe Lys Lys Asn Phe Lys Gly Ile Ile Lys Ala Val 
            100                 105                 110         


Arg Asp Leu Arg Asn Phe Tyr Thr His Lys Glu His Gly Glu Val Glu 
        115                 120                 125             


Ile Thr Asp Glu Ile Phe Gly Val Leu Asp Glu Met Leu Lys Ser Thr 
    130                 135                 140                 


Val Leu Thr Val Lys Lys Lys Lys Val Lys Thr Asp Lys Thr Lys Glu 
145                 150                 155                 160 


Ile Leu Lys Lys Ser Ile Glu Lys Gln Leu Asp Ile Leu Cys Gln Lys 
                165                 170                 175     


Lys Leu Glu Tyr Leu Arg Asp Thr Ala Arg Lys Ile Glu Glu Lys Arg 
            180                 185                 190         


Arg Asn Gln Arg Glu Arg Gly Glu Lys Lys Leu Val Ala Pro Phe Glu 
        195                 200                 205             


Tyr Ser Asp Lys Arg Asp Asp Leu Ile Ala Ala Ile Tyr Asn Asp Ala 
    210                 215                 220                 


Phe Asp Val Tyr Ile Asp Lys Lys Lys Asp Ser Leu Lys Glu Ser Ser 
225                 230                 235                 240 


Lys Thr Lys Tyr Asn Thr Glu Ser Tyr Pro Gln Gln Glu Glu Gly Asp 
                245                 250                 255     


Leu Lys Ile Pro Ile Ser Lys Asn Gly Val Val Phe Leu Leu Ser Leu 
            260                 265                 270         


Phe Leu Ser Lys Gln Glu Val His Ala Phe Lys Ser Lys Ile Ala Gly 
        275                 280                 285             


Phe Lys Ala Thr Val Ile Asp Glu Ala Thr Val Ser Glu Ala Thr Val 
    290                 295                 300                 


Ser His Arg Lys Asn Ser Ile Cys Phe Met Ala Thr His Glu Ile Phe 
305                 310                 315                 320 


Ser His Leu Ala Tyr Lys Lys Leu Lys Arg Lys Val Arg Thr Ala Glu 
                325                 330                 335     


Ile Asn Tyr Gly Lys Ala Glu Asn Ala Glu Gln Leu Phe Val Tyr Ala 
            340                 345                 350         


Lys Glu Thr Leu Met Met Gln Met Leu Asp Glu Leu Ser Lys Val Pro 
        355                 360                 365             


Asp Val Val Tyr Gln Asn Leu Ser Glu Asp Val Gln Lys Thr Phe Ile 
    370                 375                 380                 


Glu Asp Trp Asn Glu Tyr Leu Lys Glu Asn Asn Gly Asp Val Gly Thr 
385                 390                 395                 400 


Met Glu Glu Glu Gln Val Ile His Pro Val Ile Arg Lys Arg Tyr Glu 
                405                 410                 415     


Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe Ala Gln 
            420                 425                 430         


Phe Pro Thr Leu Arg Phe Gln Val His Leu Gly Asn Tyr Leu His Asp 
        435                 440                 445             


Ser Arg Pro Lys Glu Asn Leu Ile Ser Asp Arg Arg Ile Lys Glu Lys 
    450                 455                 460                 


Ile Thr Val Phe Gly Arg Leu Ser Glu Leu Glu His Lys Lys Ala Leu 
465                 470                 475                 480 


Phe Ile Lys Asn Thr Glu Thr Asn Glu Asp Arg Glu His Tyr Trp Glu 
                485                 490                 495     


Ile Phe Pro Asn Pro Asn Tyr Asp Phe Pro Lys Glu Asn Ile Ser Val 
            500                 505                 510         


Asn Asp Lys Asp Phe Pro Ile Ala Gly Ser Ile Leu Asp Arg Glu Lys 
        515                 520                 525             


Gln Pro Thr Ala Gly Lys Ile Gly Ile Lys Val Lys Leu Leu Asn Gln 
    530                 535                 540                 


Gln Tyr Ile Ser Glu Ile Asn Lys Ala Val Lys Ala His Gln Leu Lys 
545                 550                 555                 560 


Gln Arg Lys Ala Ser Lys Pro Ser Ile Gln Asn Ile Ile Glu Glu Ile 
                565                 570                 575     


Val Pro Ile Asn Gly Asn Asn Gln Glu Glu Ile Ile Val Phe Gly Gly 
            580                 585                 590         


Gln Pro Thr Ala Tyr Leu Ser Met Asn Asp Ile His Ser Ile Leu Tyr 
        595                 600                 605             


Glu Phe Phe Asp Lys Trp Glu Glu Lys Lys Glu Arg Leu Glu Lys Glu 
    610                 615                 620                 


Gly Glu Lys Lys Leu Arg Lys Glu Ile Gly Lys Glu Leu Glu Glu Lys 
625                 630                 635                 640 


Ile Val Gly Lys Ile Gln Val Gln Ile Gln Gln Ile Ile Asp Lys Asp 
                645                 650                 655     


Thr His Ala Lys Ile Leu Lys Pro Tyr Gln Asp Gly Asn Ser Thr Ala 
            660                 665                 670         


Ile Asp Lys Asp Lys Leu Ile Lys Asp Leu Lys Gln Glu Gln Asn Ile 
        675                 680                 685             


Leu Gln Lys Leu Lys Asp Glu Gln Thr Ala Arg Glu Lys Glu Tyr Lys 
    690                 695                 700                 


Glu Cys Ile Ala Tyr Gln Asp Lys Asn Arg Glu Ile Asn Lys Val Arg 
705                 710                 715                 720 


Asp Arg Asn His Lys Gln Tyr Leu Lys Asp Asn Leu Lys Arg Lys Tyr 
                725                 730                 735     


Pro Glu Ala Pro Thr Arg Lys Glu Ile Leu Tyr Tyr Gln Glu Lys Gly 
            740                 745                 750         


Lys Val Ala Val Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Thr 
        755                 760                 765             


Asp Phe Lys Asn Glu Trp Lys Gly Glu Gln His Ser Leu Leu Gln Lys 
    770                 775                 780                 


Ser Leu Ala Tyr Tyr Glu Gln Cys Lys Glu Glu Leu Lys Asn Leu Leu 
785                 790                 795                 800 


Pro Glu Lys Val Phe Gln His Phe Pro Phe Lys Leu Gly Gly Tyr Phe 
                805                 810                 815     


Gln Gln Lys Tyr Leu Tyr Gln Phe Tyr Thr Arg Tyr Leu Asp Lys Arg 
            820                 825                 830         


Leu Glu Tyr Ile Ser Gly Leu Val Gln Gln Ala Glu Asn Phe Lys Ser 
        835                 840                 845             


Glu Asn Lys Val Phe Lys Lys Val Glu Asn Glu Cys Phe Lys Phe Leu 
    850                 855                 860                 


Lys Lys Gln Asn Tyr Thr His Lys Gly Leu Asp Ala Gln Val Gln Ser 
865                 870                 875                 880 


Ile Leu Gly Tyr Pro Ile Phe Leu Glu Arg Gly Phe Met Asp Glu Lys 
                885                 890                 895     


Pro Thr Ile Ile Lys Gly Lys Thr Phe Lys Gly Asn Glu Ala Leu Phe 
            900                 905                 910         


Ala Asp Trp Phe Arg Tyr Tyr Lys Glu Tyr Gln Asn Phe Gln Thr Phe 
        915                 920                 925             


Tyr Asn Ala Lys Gln Tyr Pro Leu Val Glu Leu Glu Lys Asn Gln Ala 
    930                 935                 940                 


Asp Arg Lys Arg Lys Thr Lys Ile Tyr Gln Gln Lys Lys Asn Asp Val 
945                 950                 955                 960 


Phe Thr Leu Leu Met Ala Lys His Ile Phe Lys Ser Val Phe Lys Gln 
                965                 970                 975     


Asp Ser Ile Asp Gln Phe Ser Leu Glu Asp Leu Tyr Gln Ser Arg Glu 
            980                 985                 990         


Glu Arg Leu Glu Asn Gln Glu Lys  Ala Lys Gln Thr Gly  Glu Arg Asn 
        995                 1000                 1005             


Thr Asn  Tyr Ile Trp Asn Lys  Thr Val Asn Leu Asn  Leu Cys Asp 
    1010                 1015                 1020             


Gly Lys  Ile Thr Val Glu Asn  Val Lys Leu Lys Asn  Val Gly Asp 
    1025                 1030                 1035             


Phe Ile  Lys Tyr Glu Tyr Asp  Gln Arg Val Gln Ala  Phe Leu Lys 
    1040                 1045                 1050             


Tyr Glu  Glu Asn Ile Glu Trp  Gln Ala Phe Leu Ile  Lys Glu Ser 
    1055                 1060                 1065             


Lys Glu  Glu Glu Asn Tyr Pro  Tyr Val Val Glu Arg  Glu Ile Glu 
    1070                 1075                 1080             


Gln Tyr  Glu Lys Val Arg Arg  Glu Glu Leu Leu Lys  Glu Val His 
    1085                 1090                 1095             


Leu Ile  Glu Glu Tyr Ile Leu  Glu Lys Val Lys Asp  Lys Glu Ile 
    1100                 1105                 1110             


Leu Lys  Lys Gly Asp Asn Gln  Asn Phe Lys Tyr Tyr  Ile Leu Asn 
    1115                 1120                 1125             


Gly Leu  Leu Lys Gln Leu Lys  Asn Glu Asp Val Glu  Ser Tyr Lys 
    1130                 1135                 1140             


Val Phe  Asn Leu Asn Thr Glu  Pro Glu Asp Val Asn  Ile Asn Gln 
    1145                 1150                 1155             


Leu Lys  Gln Glu Ala Thr Asp  Leu Glu Gln Lys Ala  Phe Val Leu 
    1160                 1165                 1170             


Thr Tyr  Ile Arg Asn Lys Phe  Ala His Asn Gln Leu  Pro Lys Arg 
    1175                 1180                 1185             


Glu Phe  Trp Asp Tyr Cys Gln  Glu Lys Tyr Gly Lys  Ile Glu Lys 
    1190                 1195                 1200             


Glu Lys  Thr Tyr Ala Glu Tyr  Phe Ser Glu Ile Phe  Lys Arg Glu 
    1205                 1210                 1215             


Lys Glu  Ala Leu Ile Lys 
    1220                 


<210>  1837
<211>  1094
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1837

Met Asn Ile Pro Thr Ile Ile Glu Gln Lys Lys Gln Phe Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Val Met Ala Leu Leu Asn Val Gln Thr Val Leu Asp His Ile 
            20                  25                  30          


Gln Lys Leu Ala Asp Ile Glu Asp Ile Pro Cys Tyr Asp Glu Asn Gly 
        35                  40                  45              


Lys Glu Lys Asp Lys Arg Glu Asn Leu Trp Glu His Ser Val Met Leu 
    50                  55                  60                  


Tyr Ile Asn Tyr Lys Asn Asn Ser Ile Gln Lys Ala Pro Glu Lys Thr 
65                  70                  75                  80  


Ala Leu Ile Ile Asp Lys Leu Met Ala Tyr Phe Pro Phe Leu Lys Ile 
                85                  90                  95      


Met Ala Glu Asn Gln Arg Thr His Lys Asn Lys Lys Tyr Gln Gln Asn 
            100                 105                 110         


Arg Leu Glu Val Asn Ser Asp Asp Val Phe Asp Val Leu Asn Cys Leu 
        115                 120                 125             


Phe Arg Val Val Lys Lys Tyr Arg Asp Thr Thr Thr His Tyr Met Leu 
    130                 135                 140                 


His Asp Glu Cys Trp Asp Asp Asn Ser Lys Phe Leu Arg Cys Ser Glu 
145                 150                 155                 160 


Gln Ile Leu Ala Thr Met Leu Asn Lys Tyr Tyr Asp Val Ala Leu Arg 
                165                 170                 175     


Asn Met Lys Glu Arg Tyr Gly Tyr Thr Thr Glu Glu Leu Ala Phe Ile 
            180                 185                 190         


Gln Asn His Arg Tyr Lys Ile Glu Trp Glu Pro Asp Ser Arg Lys Arg 
        195                 200                 205             


Pro Gln Ser Asn Thr Arg Phe Phe Phe Ser Leu Val Asp Asn Asn Gly 
    210                 215                 220                 


Asp Ala Asn Pro Asp Thr Leu His Leu Ser Gly Val Gly Val Ala Val 
225                 230                 235                 240 


Leu Ile Cys Leu Leu Leu Asp Lys Gln Tyr Ile Asn Leu Phe Ala Gln 
                245                 250                 255     


Gln Leu Pro Ala Ile Gln Lys Phe Glu Pro Gln Ser Ala Ala Arg Lys 
            260                 265                 270         


Met Leu Val Arg Ser Met Gly Ile His Ser Ile Val Leu Pro Lys Asp 
        275                 280                 285             


Arg Ile His Ser Gln Lys Asp Asn Met Ser Ile Ala Met Asp Met Ile 
    290                 295                 300                 


Asn Glu Met Lys Arg Cys Pro Lys Glu Leu Phe Asp Thr Leu Ser Pro 
305                 310                 315                 320 


Ser Asp Gln Ser Arg Phe Arg Val Thr Ser Ser Asp His Asn Glu Val 
                325                 330                 335     


Leu Phe Leu Arg His Asn Asp Arg Phe Ala Gln Leu Ala Leu Gln Tyr 
            340                 345                 350         


Ile Asp Tyr Cys Lys Trp Phe Asn Gly Ile Arg Phe His Val Asn Met 
        355                 360                 365             


Gly Lys Leu Arg Tyr Leu Phe Asn Ala Glu Lys Asn Cys Ile Asp Gly 
    370                 375                 380                 


Ile Asn Arg Val Arg Val Ile Glu His Ala Leu Asn Gly Phe Gly Arg 
385                 390                 395                 400 


Ile Asp Glu Met Glu Asp Leu Arg Lys Ser Glu Val Gly Thr Phe Ala 
                405                 410                 415     


Asn Thr Gly Val Ala Ile Arg Asp Phe Glu Asn Val Lys Arg Asp Asp 
            420                 425                 430         


Ala Asp Pro Asn Asn Tyr Pro Tyr Ile Val Asp Thr Tyr Thr His Tyr 
        435                 440                 445             


Ile Leu Glu Asn Asn Lys Ile Glu Met Leu Leu Thr Asp Thr Asn Ser 
    450                 455                 460                 


Leu Pro Thr Ile Thr Glu Lys Gly Gly Lys Trp Tyr Val Gly Lys Lys 
465                 470                 475                 480 


Ala Pro Thr Cys Arg Met Ser Ile Phe Glu Leu Pro Ala Met Met Phe 
                485                 490                 495     


His Ala Ile Leu Leu Gly Asn Gln Ala Thr Glu Lys Arg Ile Lys Thr 
            500                 505                 510         


Val Cys Ala Asn Tyr Ser Arg Leu Phe Glu Ala Leu Lys Gln Gly Ala 
        515                 520                 525             


Val Asn Lys Asp Asn Ile Ala Ser Phe Gly Ile Ala Glu Glu Asp Ile 
    530                 535                 540                 


Pro Gln Lys Val Leu Asp Ile Val Asn Gly Cys Ala Gln Gly Lys Asp 
545                 550                 555                 560 


Val Asn Ile Phe Ile Lys Lys Asn Ile Asp Glu Met Leu His Asp Thr 
                565                 570                 575     


Glu Arg Arg Leu Glu Arg Leu Arg Glu Asp Arg Glu Ala Val Asn Ala 
            580                 585                 590         


Asn Asp Asn Arg Met Gly Lys Arg Gly Phe Arg Gln Ile Gln Arg Gly 
        595                 600                 605             


Lys Leu Ala Ser Phe Leu Ala Glu Asp Ile Val Lys Leu Gln Pro Thr 
    610                 615                 620                 


Leu Cys Asn Gly Thr Asp Lys Leu Thr Gly Leu Asn Tyr Arg Val Leu 
625                 630                 635                 640 


Gln Ala Ser Leu Ala Val Tyr Asp Ser Gly Gly Met Asn Glu Ala Arg 
                645                 650                 655     


Gln Gln Phe Lys Ala Leu Phe Val Lys Ala His Leu Leu Gly Thr Asp 
            660                 665                 670         


Pro His Thr Cys His Pro Phe Leu His Lys Val Phe Ala Arg Ser Ile 
        675                 680                 685             


Pro Asp Asn Thr Ile Asp Phe Tyr Glu Arg Tyr Leu Ala Glu Arg Glu 
    690                 695                 700                 


Ser Tyr Leu Ser Thr Ile Gln Lys Lys Val Ala Met Gly Lys Ala Val 
705                 710                 715                 720 


Asn Val Pro Phe Ile Asn Arg Ala Gln Ser Lys Trp Ser Ala Pro Thr 
                725                 730                 735     


Gln Glu Ala Leu Gly Asn Ala Tyr Thr Asp Asp Met Ala Ile Glu Leu 
            740                 745                 750         


Pro Arg Gln Met Phe Asp Asp Glu Ile Lys Ala His Leu Lys Thr Leu 
        755                 760                 765             


Pro Glu Met Ala Asp Ile Asp Phe Asp Asn Ala Asn Ile Thr Phe Leu 
    770                 775                 780                 


Ile Gly Glu Tyr Gln Lys Arg Val Leu His Asp Asn Val Gln His Phe 
785                 790                 795                 800 


Tyr Ser Trp Gln Arg Asn Tyr Arg Tyr Ile Asp Met Leu Lys Cys Glu 
                805                 810                 815     


Thr Asp Arg Lys Asn Cys Leu Cys Ser Thr Tyr Thr Ser Val Glu Glu 
            820                 825                 830         


Arg Glu Ala Leu Trp Gly Arg Arg Lys Glu Cys Ile Glu Lys Tyr Arg 
        835                 840                 845             


Gln Trp Phe Thr Arg Lys Thr Ser Asn Asp Arg Gly Arg Ser Leu Ile 
    850                 855                 860                 


Ser Ala Val Asp Ile Glu Glu Ile Leu Asp Lys Arg Leu Ser Asn Ala 
865                 870                 875                 880 


Arg Asn Glu Tyr Gln Lys Cys Glu Lys Thr Ile Arg Arg Phe Lys Val 
                885                 890                 895     


Gln Asp Thr Leu Leu Phe Ile Leu Ala Lys Lys Ala Leu Thr Asn Phe 
            900                 905                 910         


Ala Asp Tyr Asn Gly Glu Arg Phe Cys Leu Asn Asp Ile Thr Pro Glu 
        915                 920                 925             


Gly Asp Lys Gly Ile Leu Ser Gln Leu Met Pro Met Ile Phe Arg Phe 
    930                 935                 940                 


Glu Lys Lys Gly Lys Val Tyr Thr Ile Lys Ser Glu Ser Met Lys Pro 
945                 950                 955                 960 


Lys Asn Tyr Gly Asp Phe Phe Val Ile Ala Asn Asp Asn Arg Ile Cys 
                965                 970                 975     


Asn Leu Leu Asp Leu Ile Glu Asp Asn Ile Val Ser Lys Glu Asp Ile 
            980                 985                 990         


Asp Lys Glu Leu Gln Lys Tyr Asp  Gln Cys Arg Pro Glu  Met Ala Lys 
        995                 1000                 1005             


Leu Val  Leu Asp Leu Glu Lys  Trp Thr Tyr Ser Lys  Ser Pro Gly 
    1010                 1015                 1020             


Leu Met  Tyr Lys Glu Lys Val  Gln Phe Lys Asp Val  Leu Asp Glu 
    1025                 1030                 1035             


Leu Cys  Lys His Thr Asn Leu  Thr Glu Arg Gln Lys  Phe Val Leu 
    1040                 1045                 1050             


Gly Lys  Val Arg Asn Ala Phe  Glu His Asn Asp Tyr  Pro Glu Lys 
    1055                 1060                 1065             


Gly Ile  Leu Glu Ile Thr Thr  Leu Pro Gln Ile Ala  Ala Arg Met 
    1070                 1075                 1080             


Lys Asp  Leu Phe Asp Glu Tyr  Ala Glu Val Glu 
    1085                 1090                 


<210>  1838
<211>  1081
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1838

Met Gln Ala Gln Ser Leu Phe Asp Glu Tyr Lys His Leu Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Val Met Ser Ile Met Asn Ile Ile Thr Val Leu Asn His Ile 
            20                  25                  30          


His Gln Ile Ala Gly Leu Lys Arg Asn Glu Leu Gly Asp Asp Asp Asn 
        35                  40                  45              


Ile Tyr Ser His Pro Val Leu Lys Tyr Ile Ala Pro Glu Asn Asn Ser 
    50                  55                  60                  


Thr Thr Leu Pro Glu Lys Arg Asp Leu Ile Lys Glu Leu Leu Leu Glu 
65                  70                  75                  80  


Tyr Leu Pro Phe Leu Glu Ala Met Lys Asp Cys Tyr Lys Glu Val Lys 
                85                  90                  95      


Val Glu Lys Asp Lys Arg Asn Asn Lys Tyr Val Lys Asp Lys Lys Gln 
            100                 105                 110         


Val Phe Ile Arg Asn Tyr Ser Asp Ile Tyr Cys Ile Tyr Trp Thr Leu 
        115                 120                 125             


Tyr Asn Ile Phe Ser Thr Leu Ile Asn Tyr Arg Asp Lys Ser Cys His 
    130                 135                 140                 


Tyr Arg Phe Ile Pro Ser Lys Asp Gln Glu Glu Tyr Ser Lys Arg Thr 
145                 150                 155                 160 


Glu Tyr Asp Thr Val Arg Ile Ile Asn Lys Tyr Tyr Thr Tyr Ala Leu 
                165                 170                 175     


Arg Lys Thr Lys Glu Lys Tyr Gly Tyr Thr Thr Glu Gln Leu Ser Phe 
            180                 185                 190         


Ile Gln Asn Asn Arg Tyr Thr Asp Asp Lys Lys Val Asn Phe Asn Phe 
        195                 200                 205             


Phe Leu Ser Met Gln Ser Ser Asn Asn Asn Leu Ser His Val Gly Val 
    210                 215                 220                 


Ala Gln Leu Ile Cys Leu Phe Leu Gln Lys Lys Asp Val Asp Asn Phe 
225                 230                 235                 240 


Leu Glu Asn Leu Pro Ile Tyr Asp Asn Arg Tyr Cys Leu Gly Ile Asp 
                245                 250                 255     


Glu His Met Ile Ile Lys Arg Ser Leu Ala Leu His Ser Ile Lys Leu 
            260                 265                 270         


Pro Lys Glu Arg Leu Asn Ser Glu Lys Lys Asp Met Ala Ile Ala Met 
        275                 280                 285             


Asp Met Leu Asn Glu Leu Lys Arg Cys Pro Lys Glu Leu Phe Asn Thr 
    290                 295                 300                 


Leu Pro Phe Asp Lys Gln Glu Arg Phe Arg Ile Ile Ser Ser Asp His 
305                 310                 315                 320 


Lys Glu Val Leu Leu Met Arg Ser Thr Asp Arg Phe Val Pro Leu Ile 
                325                 330                 335     


Leu Gln Tyr Ile Asp Cys Asn Lys Lys Phe Lys Asp Ile Arg Phe His 
            340                 345                 350         


Val Asn Met Gly Lys Leu Arg Tyr Leu Phe Ser Pro Asn Lys Leu Cys 
        355                 360                 365             


Ile Asp Asn Gln Glu Arg Val Arg Met Leu Glu His Leu Leu Asn Gly 
    370                 375                 380                 


Tyr Gly Arg Ile Asp Glu Val Glu Tyr Leu Arg Lys Ala Pro Asn Gly 
385                 390                 395                 400 


Thr Phe Gly Asn Thr Asn Ile Pro Ile Lys Gly Phe Gly Glu Ile Glu 
                405                 410                 415     


Arg Asp Ser Ala Asp Ser Asn Asn Tyr Pro Tyr Ile Val Asp Thr His 
            420                 425                 430         


Thr His Tyr Ile Leu Asn Asn Asn Lys Val Glu Phe Cys Phe Cys Glu 
        435                 440                 445             


Asp Ser Lys Asn Lys Asn Val Phe Pro Thr Ile Glu Lys Glu Ile Asn 
    450                 455                 460                 


Gly Lys Trp Tyr Val Glu Lys Thr Ala Pro His Cys Arg Ile Ser Phe 
465                 470                 475                 480 


Phe Glu Ile Pro Ala Met Ala Phe His Met Phe Leu Cys Gly Ser Glu 
                485                 490                 495     


Lys Thr Glu Lys Leu Ile Lys Asp Val Tyr Asn Asn Tyr Ile Ser Leu 
            500                 505                 510         


Phe Asn Ala Leu Lys Asn Gly Ala Leu Thr Glu Glu Asn Tyr Lys Asp 
        515                 520                 525             


Phe Asn Ile Pro Glu Cys Asp Met Pro Lys Lys Ile Leu Asp Phe Leu 
    530                 535                 540                 


Lys Gly Lys Ala Glu Gly Lys Ser Ile Asp Gly Tyr Val Lys Asn Ile 
545                 550                 555                 560 


Leu Lys Lys Glu Leu Lys Asp Thr Arg Lys Arg Ile Glu Gln Ala Pro 
                565                 570                 575     


Ser Glu Lys Asp Gln Met Pro Ser Lys Arg Asn Lys Ile Gly Thr Lys 
            580                 585                 590         


Ser Tyr Lys Arg Val Leu Thr Gly Lys Leu Ala Asp Phe Leu Ala Lys 
        595                 600                 605             


Asp Ile Val Lys Tyr Gln Pro Thr Leu Cys Ala Gly Asp Asp Tyr Gly 
    610                 615                 620                 


Ile Asp Arg Met Thr Gly Met Asn Tyr Arg Ile Met Gln Ala Thr Ile 
625                 630                 635                 640 


Ala Thr Tyr Asn Asp Asp Asp Asp Phe Asp Thr Phe Tyr Asn Val Phe 
                645                 650                 655     


Lys Met Ala Gly Leu Val Asp Gly Asp Glu Arg Lys Asn His Pro Phe 
            660                 665                 670         


Leu Lys Lys Val Leu Leu Ser Lys Pro Gln Asn Thr Val Ala Phe Asn 
        675                 680                 685             


Ile Lys Tyr Leu Lys Glu Lys Glu Ile Tyr Leu Arg Asn Ile Glu Lys 
    690                 695                 700                 


Lys Asn Ile Ile Pro Pro Phe Val Asn Arg Glu Arg Asn Lys Trp Cys 
705                 710                 715                 720 


Glu Arg Asp Cys Glu Tyr Tyr Arg Ile Leu Gly Glu Asn Leu Leu Asp 
                725                 730                 735     


Leu Pro Ile Glu Leu Pro Arg Gln Met Phe Tyr Lys Asp Ile Arg Ala 
            740                 745                 750         


Gln Leu Glu Pro Leu Met Pro Glu Ile Asp Phe Ser Gln Thr Asn Thr 
        755                 760                 765             


Thr Tyr Leu Ile Ala Glu Tyr Leu Lys Arg Val Arg Gly Asp Asp Phe 
    770                 775                 780                 


Gln Glu Phe Tyr Ser Trp Glu Arg Asn Tyr Arg Tyr Ile Asp Phe Leu 
785                 790                 795                 800 


Lys Cys Ile Arg Asp Asp Asn Gly Arg Ile Cys Ala Gln Tyr Thr Thr 
                805                 810                 815     


Thr Glu Glu Arg Glu Ser Leu Trp Glu Asp Ser Lys Asn Arg Thr Ala 
            820                 825                 830         


Glu Tyr Lys Arg Ser Glu Glu Gln Lys Asn Glu Lys Lys Asp Lys Asn 
        835                 840                 845             


Phe Glu Asp Ser Leu Glu Glu Arg Ile Ser Ser Ser His Ile Lys Phe 
    850                 855                 860                 


Gln Asn Thr Glu Lys His Ile Arg Arg Tyr Lys Val Gln Asp Ala Leu 
865                 870                 875                 880 


Leu Phe Met Ile Ala Glu Lys Gln Phe Gly Lys Tyr Leu Asp Asp Ile 
                885                 890                 895     


Lys Ala Lys Asn Phe Lys Leu Lys Asp Ile Met Pro Asp Thr Asp Lys 
            900                 905                 910         


Gly Ile Leu Ser Glu Thr Met Pro Ile Asp Phe Thr Phe Thr Lys Lys 
        915                 920                 925             


Asn Ile Lys Tyr Asn Ile His Ala Lys Asn Leu Lys Phe Lys Glu Tyr 
    930                 935                 940                 


Gly Asp Leu Phe Ile Leu Ala Asn Asp Lys Arg Leu Glu Ser Leu Trp 
945                 950                 955                 960 


Lys Ile Leu Ala Thr Asp Thr Val Asn Lys Glu Glu Ile Ser Glu Glu 
                965                 970                 975     


Phe Ala Lys Tyr Asp Phe Cys Arg Pro Asp Ile Thr Lys Leu Val Leu 
            980                 985                 990         


Asp Phe Glu Lys Asp Val Leu Glu  Lys Tyr Pro Glu Ile  Ile Glu Glu 
        995                 1000                 1005             


Ala Glu  Lys Glu Tyr Lys Lys  Phe Asp Phe Lys Phe  Ile Leu Asp 
    1010                 1015                 1020             


Trp Leu  Ile Asn Lys Lys Lys  Leu Asn Tyr Gly Ile  Arg Asn Lys 
    1025                 1030                 1035             


Leu Leu  Leu Ile Arg Asn Ala  Phe Asn His Asn Ser  Tyr Pro Asp 
    1040                 1045                 1050             


Lys Lys  Tyr Ala Glu Val Arg  Glu Leu Pro Glu Ile  Ala Thr Asn 
    1055                 1060                 1065             


Leu Lys  Lys Thr Phe Asp Glu  Asn Ala Lys Lys Tyr  Glu 
    1070                 1075                 1080     


<210>  1839
<211>  1165
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1839

Met Lys Asn Gln Asn Ser Leu Pro Ser Asn Pro Thr Asp Ile Leu Glu 
1               5                   10                  15      


Asp Lys Pro Phe Trp Ala Ala Phe Phe Asn Leu Ala Arg His Asn Val 
            20                  25                  30          


Tyr Leu Thr Val Asn His Ile Asn Lys Leu Leu Asp Leu Glu Lys Leu 
        35                  40                  45              


Tyr Asn Lys Asp Lys His Lys Glu Ile Phe Glu His Glu Asp Ile Phe 
    50                  55                  60                  


Asn Ile Ser Asp Asp Val Met Asn Asp Ala Asn Ser Asn Gly Lys Lys 
65                  70                  75                  80  


Arg Lys Leu Asp Ile Lys Lys Ile Trp Asp Asp Leu Asp Thr Asp Leu 
                85                  90                  95      


Thr Arg Lys Tyr Leu Leu Arg Glu Leu Ile Leu Lys His Phe Pro Phe 
            100                 105                 110         


Ile Gln Pro Ala Ile Ile Gly Thr Gln Thr Lys Glu Arg Thr Thr Ile 
        115                 120                 125             


Asp Lys Asp Lys Lys Arg Thr Ser Thr Ser Asn Asp Ser Leu Lys Gln 
    130                 135                 140                 


Thr Gly Glu Gly Asp Ile Asn Asp Pro Leu Ser Leu Ser Asn Val Lys 
145                 150                 155                 160 


Ser Met Phe Phe Arg Leu Leu Gln Met Leu Glu Gln Leu Arg Asn Tyr 
                165                 170                 175     


Tyr Ser His Val Lys His Ser Lys Ser Ala Thr Met Pro Asn Phe Asp 
            180                 185                 190         


Glu Gly Leu Leu Lys Ser Met Tyr Asn Ile Phe Ile Asp Ser Val Asn 
        195                 200                 205             


Lys Val Lys Glu Asp Tyr Ser Ser Asn Ser Val Ile Asp Pro Asn Thr 
    210                 215                 220                 


Ser Phe Ser His Leu Ile Tyr Lys Asp Lys Tyr Gly Glu Ile Lys Pro 
225                 230                 235                 240 


Cys Arg Tyr Pro Phe Thr Ser Lys Asp Gly Ser Ile Asn Ala Ser Gly 
                245                 250                 255     


Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys Gln Asp Ser Ile Trp 
            260                 265                 270         


Met Gln Lys Lys Ile Pro Gly Phe Lys Lys Ala Ser Glu Asn Tyr Met 
        275                 280                 285             


Lys Met Thr Asn Glu Val Phe Cys Arg Asn His Ile Leu Leu Pro Lys 
    290                 295                 300                 


Met Arg Leu Glu Ala Val Tyr Asp Lys Asp Trp Met Leu Leu Asp Met 
305                 310                 315                 320 


Leu Asn Glu Val Val Arg Cys Pro Leu Ser Leu Tyr Lys Arg Leu Thr 
                325                 330                 335     


Pro Ala Asp Gln Asn Lys Phe Lys Val Pro Glu Lys Ser Ser Asp Asn 
            340                 345                 350         


Ala Asn Gln Gln Glu Asp Asp Asn Pro Phe Ser Arg Ile Leu Val Arg 
        355                 360                 365             


His Gln Asn Arg Phe Pro Tyr Phe Val Leu Arg Phe Phe Asp Leu Asn 
    370                 375                 380                 


Glu Val Phe Thr Thr Leu Arg Phe Gln Ile Asn Leu Gly Cys Tyr His 
385                 390                 395                 400 


Phe Ala Ile Tyr Lys Lys Gln Ile Gly Asp Lys Lys Glu Val His His 
                405                 410                 415     


Leu Thr Arg Thr Leu Tyr Gly Phe Ser Arg Leu Gln Asn Phe Thr Gln 
            420                 425                 430         


Asn Thr Arg Pro Glu Glu Trp Asn Thr Leu Val Lys Thr Thr Glu Pro 
        435                 440                 445             


Ser Ser Gly Asn Asp Gly Lys Met Val Gln Gly Val Pro Leu Pro Tyr 
    450                 455                 460                 


Ile Ser Tyr Thr Ile Pro His Tyr Gln Ile Glu Asn Glu Lys Ile Gly 
465                 470                 475                 480 


Ile Lys Ile Phe Gly Glu Asp Thr Ala Val Asp Thr Asp Ile Trp Pro 
                485                 490                 495     


Ser Val Ser Thr Glu Lys Gln Leu Asn Lys Pro Asp Lys Tyr Thr Leu 
            500                 505                 510         


Thr Pro Gly Phe Lys Ala Asp Val Phe Leu Ser Val His Glu Leu Leu 
        515                 520                 525             


Pro Met Met Phe Tyr Tyr Gln Leu Leu Leu Cys Glu Gly Met Leu Lys 
    530                 535                 540                 


Thr Asp Ala Gly Asn Ala Val Glu Lys Val Leu Ile Asp Thr Arg Asn 
545                 550                 555                 560 


Ala Ile Phe Asn Leu Tyr Asp Ala Phe Val Gln Glu Lys Ile Asn Thr 
                565                 570                 575     


Ile Thr Asp Leu Glu Asn Tyr Leu Gln Asp Lys Pro Ile Leu Ile Gly 
            580                 585                 590         


His Leu Pro Lys Gln Met Ile Asp Leu Leu Lys Gly His Gln Arg Asp 
        595                 600                 605             


Met Leu Lys Ala Val Glu Gln Lys Lys Ala Met Leu Ile Lys Asp Thr 
    610                 615                 620                 


Glu Arg Arg Leu Glu Arg Leu Asn Lys Gln Pro Glu Gln Lys Pro Asn 
625                 630                 635                 640 


Val Ala Ala Lys Asn Thr Gly Thr Leu Leu Arg Asn Gly Gln Ile Ala 
                645                 650                 655     


Asp Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Lys Arg Asp 
            660                 665                 670         


Lys Glu Gly Asn Pro Ile Asn Cys Ser Lys Ala Asn Ser Thr Glu Tyr 
        675                 680                 685             


Gln Met Leu Gln Arg Ala Phe Ala Phe Tyr Thr Thr Asp Ser Tyr Arg 
    690                 695                 700                 


Leu Pro Arg Tyr Phe Glu Gln Leu His Leu Ile Asn Cys Asp Asn Ser 
705                 710                 715                 720 


His Leu Phe Leu Ser Arg Phe Glu Tyr Asp Lys Gln Pro Asn Leu Ile 
                725                 730                 735     


Ala Phe Tyr Ala Ala Tyr Leu Glu Ala Lys Leu Glu Phe Leu Asn Glu 
            740                 745                 750         


Leu Gln Pro Gln Asn Trp Ala Ser Asp Asn Tyr Phe Leu Leu Leu Arg 
        755                 760                 765             


Ala Pro Lys Asn Asp Arg Gln Lys Leu Ala Glu Gly Trp Lys Asn Gly 
    770                 775                 780                 


Phe Asn Leu Pro Arg Gly Leu Phe Thr Glu Lys Ile Lys Thr Trp Phe 
785                 790                 795                 800 


Asn Glu His Lys Thr Ile Val Asp Ile Ser Asp Cys Asp Ile Phe Lys 
                805                 810                 815     


Asn Arg Val Gly Gln Val Ala Arg Leu Ile Pro Val Phe Phe Asp Lys 
            820                 825                 830         


Lys Phe Lys Asp His Ser Gln Pro Phe Tyr Arg Tyr Asn Phe Asn Val 
        835                 840                 845             


Gly Asn Val Ser Lys Pro Thr Glu Ala Asn Tyr Leu Ser Lys Gly Lys 
    850                 855                 860                 


Arg Glu Glu Leu Phe Lys Ser Tyr Gln Asn Lys Phe Lys Asn Asn Ile 
865                 870                 875                 880 


Pro Ala Glu Lys Thr Lys Glu Tyr Arg Glu Tyr Lys Asn Phe Ser Ser 
                885                 890                 895     


Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys Asn Gln Asp Ile 
            900                 905                 910         


Leu Thr Trp Leu Met Cys Lys Asn Leu Phe Asp Glu Lys Ile Lys Pro 
        915                 920                 925             


Gln Lys Asp Ile Leu Glu Pro Arg Ile Ala Val Ser Tyr Ile Lys Leu 
    930                 935                 940                 


Asp Ser Leu Gln Thr Asn Thr Ser Thr Ala Gly Ser Leu Asn Ala Leu 
945                 950                 955                 960 


Ala Lys Val Val Pro Met Thr Leu Ala Ile His Ile Asp Ser Pro Lys 
                965                 970                 975     


Pro Lys Gly Lys Ala Arg Asn Asn Glu Lys Glu Asn Lys Glu Phe Thr 
            980                 985                 990         


Val Tyr Ile Lys Glu Glu Gly Thr  Lys Leu Leu Lys Trp  Gly Asn Phe 
        995                 1000                 1005             


Lys Thr  Leu Leu Ala Asp Arg  Arg Ile Lys Gly Leu  Phe Ser Tyr 
    1010                 1015                 1020             


Ile Glu  His Asp Asp Ile Asn  Leu Glu Lys Tyr Pro  Leu Thr Lys 
    1025                 1030                 1035             


Tyr Gln  Val Asp Ser Glu Leu  Asp Leu Tyr Gln Lys  Tyr Arg Ile 
    1040                 1045                 1050             


Asp Ile  Phe Lys Gln Thr Leu  Asp Leu Glu Ala Gln  Leu Leu Asp 
    1055                 1060                 1065             


Lys Tyr  Ser Asp Leu Asn Thr  Asp Asn Phe Tyr Gln  Met Leu Ile 
    1070                 1075                 1080             


Gly Trp  Arg Lys Lys Glu Gly  Ile Pro Arg Asp Ile  Lys Glu Asp 
    1085                 1090                 1095             


Thr Asp  Phe Leu Lys Asp Val  Arg Asn Ala Phe Ser  His Asn Gln 
    1100                 1105                 1110             


Tyr Pro  Asp Ser Lys Lys Ile  Ala Phe Ser Arg Ile  Arg Lys Phe 
    1115                 1120                 1125             


Asn Pro  Lys Glu Leu Ile Leu  Glu Glu Lys Lys Gly  Leu Ser Ile 
    1130                 1135                 1140             


Ala Lys  Gln Met Tyr Glu Glu  Val Glu Lys Val Val  Asn Arg Ile 
    1145                 1150                 1155             


Lys Glu  Ile Glu Leu Phe Asp  
    1160                 1165 


<210>  1840
<211>  1085
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1840

Met Lys Lys Glu Leu Asn Arg Glu Asp Val Phe Thr Gly Gly Lys Thr 
1               5                   10                  15      


Pro Glu Leu Thr Ile Tyr Tyr Asn Ile Ala Tyr Phe Arg Met Ala Gly 
            20                  25                  30          


Leu Ile Asn Ala Leu Cys Gly Asn Lys Leu Glu Arg Asp Lys Asp Ala 
        35                  40                  45              


Leu Glu Gln Phe Met Lys Ala Phe Ile Asn Gly Lys Gln Lys Leu Thr 
    50                  55                  60                  


Asp Met Gln Phe Val Lys Leu Cys Asp Tyr Leu Trp Lys Gly Tyr Lys 
65                  70                  75                  80  


Tyr Asp Lys Asn Arg Ser Glu Tyr Ser Leu Thr Glu Asn Asp Lys Thr 
                85                  90                  95      


Met Val Leu Lys Met Val Ala Lys Leu Gln Asp Ile Arg Asn Phe Gln 
            100                 105                 110         


Ser His Ile Trp His Asp Asn Lys Val Leu Val Phe Asp Ala Asp Leu 
        115                 120                 125             


Val Gln Phe Ile Lys Asn Lys His Leu Glu Ala Ile Asp Ala Gln Arg 
    130                 135                 140                 


Gln Arg Phe Ser Lys Glu Thr Glu Val Tyr Glu Lys Glu Asn Arg Glu 
145                 150                 155                 160 


Leu Lys Lys Lys Lys Asn Lys Glu Leu Leu Phe Asp Ile His Asp Gly 
                165                 170                 175     


Leu Gly Tyr Ile Thr Gly Glu Gly Arg Asn Phe Phe Leu Ser Phe Phe 
            180                 185                 190         


Leu Thr Arg Gly Glu Met Thr Arg Phe Leu Lys Gln Arg Lys Gly Cys 
        195                 200                 205             


Lys Arg Asp Asp Thr Pro Glu Tyr Lys Ile Lys His Leu Val Tyr Arg 
    210                 215                 220                 


His Phe Thr His Arg Asp Gly Ala Thr Arg Thr His Tyr Gly Tyr Glu 
225                 230                 235                 240 


Asp Asn Met Leu Asp Gln Leu Pro Asp Lys Gln Glu Phe Leu Thr Thr 
                245                 250                 255     


Arg His Thr Tyr Arg Leu Ile Asn Tyr Leu Asn Asp Ile Pro Glu Glu 
            260                 265                 270         


Val Thr Asn Pro Glu Leu Phe Pro Leu Phe Asn Thr Ile Ser Asn Gly 
        275                 280                 285             


Ile Leu Ile Lys Glu Ser Val Gly Thr Tyr Ile Ala Phe Ile Asn Lys 
    290                 295                 300                 


Met Pro Leu Leu Ser Asp Phe Glu Phe Ser Glu Val Trp Gly Lys Asp 
305                 310                 315                 320 


Gly Lys Pro Tyr Thr Asn Leu Val Glu Phe Tyr His Lys Thr Gln Pro 
                325                 330                 335     


Gly Phe Lys Phe Arg Thr Asp Leu Asn Ser Phe His Lys Ile Ile Leu 
            340                 345                 350         


Asn Leu Ile Arg Asp Glu Asn Tyr Thr Gly Phe Phe Thr Thr Gln Leu 
        355                 360                 365             


Asn Leu Phe Met Ala His Arg Glu Glu Leu Ile Leu Val Ile Ser Lys 
    370                 375                 380                 


Pro Leu Ile Thr Pro Asn Asp Leu Leu Leu Ile Glu Glu His Tyr Arg 
385                 390                 395                 400 


Tyr Lys Leu Lys Ala Asn Asp Phe Val Arg Glu Lys Leu Gly Glu Trp 
                405                 410                 415     


Lys Glu Lys Ile Glu Lys Gly Lys Trp Glu Lys Ala Asn Glu Gln Lys 
            420                 425                 430         


Asp Lys Leu Ile Asn Leu Leu Gly Gly Val Ile Glu Ile Thr Phe Tyr 
        435                 440                 445             


Asp Phe Tyr Trp Gln Lys Asp Glu Lys Pro Arg Asn Glu Asn Arg Phe 
    450                 455                 460                 


Met Glu Phe Ala Ile Arg Phe Met Ala Asp Phe Asn Leu Leu Pro Asp 
465                 470                 475                 480 


Cys Glu Trp Glu Val Glu Pro Leu Gln Ile Glu Asn Asp Leu Ile Ala 
                485                 490                 495     


Asn Arg Thr Ala Thr Pro Asp Leu Lys Lys Ser Gly Ser Gln Phe Met 
            500                 505                 510         


Asn Gln Leu Thr Asp Asn Tyr Arg Leu Lys Phe Asn Asp Gly Gln Ile 
        515                 520                 525             


Ala Phe Arg Tyr Gln Asn Gln Val Phe Ile Met Gly His Lys Ala Val 
    530                 535                 540                 


Lys Asn Leu Leu Ile Ala Cys Phe Asp Gly Lys Glu Lys Met Leu Asn 
545                 550                 555                 560 


Gly Phe Met Pro Ala Leu Leu Ala Asp Leu Lys Lys Ile Thr Asn Glu 
                565                 570                 575     


His Ile Leu Lys Asn His Gln Ala Leu Asn Thr Leu Ser Leu Leu Asn 
            580                 585                 590         


Asn Asp Ser Ile Pro Ser Tyr Ile Ser Arg Gln Trp Gly Glu Ala Glu 
        595                 600                 605             


Pro Ile Thr Asp Met Lys Lys Lys Ala Ile Ala Arg Met Asp Tyr Ile 
    610                 615                 620                 


Thr Gln Gln Phe Glu Ala Leu Ile Glu Asn His His Tyr Leu Asn Arg 
625                 630                 635                 640 


Ala Asp Lys Asn Arg Gln Ile Met Arg Cys Tyr Lys Phe Phe Glu Trp 
                645                 650                 655     


Gln Tyr Pro Gln Asn Ser Gln Phe Lys Phe Leu Arg Arg Asn Glu Tyr 
            660                 665                 670         


His Arg Met Ser Ile Tyr His Tyr Cys Leu Asp Lys Glu Gln His Lys 
        675                 680                 685             


Tyr Asp Lys Lys Gly His Asn Tyr Leu Tyr Asn Arg Leu Ile Lys Glu 
    690                 695                 700                 


Ser His Asn Glu Ser Gly Asn Ile Glu Gln His Leu Pro Tyr Gln Ile 
705                 710                 715                 720 


Arg Thr Met Leu Asn Asp Ala Lys Asp Phe Asn Asp Tyr Phe Leu Arg 
                725                 730                 735     


Ile Leu Asn Ala Thr His Lys Ile Leu Thr Asp Trp Lys Asn Gln Leu 
            740                 745                 750         


Lys Gln Gly Arg Glu Pro Asn Asn Tyr Tyr Leu Ser Arg Leu Gly Phe 
        755                 760                 765             


Thr Gly Gly Leu Thr Gln Lys Val Val His Thr Arg Leu Leu Pro Phe 
    770                 775                 780                 


Ser Ile His Pro Gly Ile Pro Val Ser Phe Phe Tyr Arg Thr Glu Met 
785                 790                 795                 800 


Asn Gln Asn Pro Ser Phe Asn Leu Ser Ala Lys Val Trp Asn Ser Glu 
                805                 810                 815     


Ser Pro Phe Arg Val Gly Leu Lys Glu Ser Asn Tyr Gln Tyr Ala Lys 
            820                 825                 830         


Tyr Leu Gly Leu Phe Asn Glu Ile Lys Thr Gln Arg Lys Ile Ile Gly 
        835                 840                 845             


Lys Met Asn Gln Leu Ile Ala Glu Asp Ala Leu Leu Trp Gln Ile Ala 
    850                 855                 860                 


Lys Lys Tyr Leu Asp Lys Cys His Pro Lys Phe Ser Glu Ile Ile Asn 
865                 870                 875                 880 


Gln Gln Val Asn Gly Lys Gln Pro Leu Asn Val Lys Ala Ile His Asp 
                885                 890                 895     


Thr Glu Leu Thr Ile Asp Phe Pro Val Asp Lys Asn Leu Tyr Gln Val 
            900                 905                 910         


Val Val Lys Met Lys Gln Leu Asp Asp Phe Met Phe Ile Asp Ser Lys 
        915                 920                 925             


Pro Val Leu Glu Lys Thr Ile Arg Tyr Met Ile Lys Asn Ser Leu Arg 
    930                 935                 940                 


Asp Lys Glu Tyr Gln Gln Arg Val Phe Ile Glu Thr Asn Pro Gly Val 
945                 950                 955                 960 


Phe Lys Ile Pro Tyr Asn Glu Val Val Glu Ala Met Arg Thr Ile Asn 
                965                 970                 975     


His Gln Ala Leu Thr Trp Ala Arg Leu Leu Leu Asp Trp Glu Ser Lys 
            980                 985                 990         


Thr Val Lys Thr Ile Pro Glu Ala  Asp Lys Lys Ala Lys  Leu Gln Glu 
        995                 1000                 1005             


Ala Tyr  Asn Lys Arg Gln Pro  Ala Phe Phe Asn Phe  Asn Asp Ile 
    1010                 1015                 1020             


Cys Arg  Tyr Ala Asp Asp Gly  Lys Gln Leu Lys Asp  Leu Arg Asn 
    1025                 1030                 1035             


Lys Thr  Phe His Thr Glu Val  Pro Glu Thr Trp Thr  Tyr Asp Glu 
    1040                 1045                 1050             


Met Arg  Glu Asn Lys Thr Ile  Lys Met Val Leu Gly  Ile Asn Glu 
    1055                 1060                 1065             


Thr Thr  Phe Leu Lys Lys Asp  Tyr Ala Ile Glu Asn  Ala Arg Thr 
    1070                 1075                 1080             


Ile Glu  
    1085 


<210>  1841
<211>  1081
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1841

Met Gln Ala Gln Ser Leu Phe Asp Glu Tyr Lys His Leu Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Val Met Ser Ile Met Asn Ile Ile Thr Val Leu Asn His Ile 
            20                  25                  30          


His Gln Ile Ala Gly Leu Lys Arg Asn Glu Leu Gly Asp Asp Asp Asn 
        35                  40                  45              


Ile Tyr Ser His Pro Val Leu Lys Tyr Ile Ala Pro Glu Asn Asn Ser 
    50                  55                  60                  


Thr Thr Leu Pro Glu Lys Arg Asp Leu Ile Lys Glu Leu Leu Leu Glu 
65                  70                  75                  80  


Tyr Leu Pro Phe Leu Glu Ala Met Lys Asp Cys Tyr Lys Glu Val Lys 
                85                  90                  95      


Val Glu Lys Asp Lys Arg Asn Asn Lys Tyr Val Lys Asp Lys Lys Gln 
            100                 105                 110         


Val Phe Ile Arg Asn Tyr Ser Asp Ile Tyr Cys Ile Tyr Trp Thr Leu 
        115                 120                 125             


Tyr Asn Ile Phe Ser Thr Leu Ile Asn Tyr Arg Asp Lys Ser Cys His 
    130                 135                 140                 


Tyr Arg Phe Ile Pro Ser Lys Asp Gln Glu Glu Tyr Ser Lys Arg Thr 
145                 150                 155                 160 


Glu Tyr Asp Thr Val Arg Ile Ile Asn Lys Tyr Tyr Thr Tyr Ala Leu 
                165                 170                 175     


Arg Lys Thr Lys Glu Lys Tyr Gly Tyr Thr Thr Glu Gln Leu Ser Phe 
            180                 185                 190         


Ile Gln Asn Asn Arg Tyr Thr Asp Asp Lys Lys Val Asn Phe Asn Phe 
        195                 200                 205             


Phe Leu Ser Met Gln Ser Ser Asn Asn Asn Leu Ser His Val Gly Val 
    210                 215                 220                 


Ala Gln Leu Ile Cys Leu Phe Leu Gln Lys Lys Asp Val Asp Asn Phe 
225                 230                 235                 240 


Leu Glu Asn Leu Pro Ile Tyr Asp Asn Arg Tyr Cys Leu Gly Ile Asp 
                245                 250                 255     


Glu His Met Ile Ile Lys Arg Ser Leu Ala Leu His Ser Ile Lys Leu 
            260                 265                 270         


Pro Lys Glu Arg Leu Asn Ser Glu Lys Lys Asp Met Ala Ile Ala Met 
        275                 280                 285             


Asp Met Leu Asn Glu Leu Lys Arg Cys Pro Lys Glu Leu Phe Asn Thr 
    290                 295                 300                 


Leu Pro Phe Asp Lys Gln Glu Arg Phe Arg Ile Ile Ser Ser Asp His 
305                 310                 315                 320 


Lys Glu Val Leu Leu Met Arg Ser Thr Asp Arg Phe Val Pro Leu Ile 
                325                 330                 335     


Leu Gln Tyr Ile Asp Cys Asn Lys Lys Phe Lys Asp Ile Arg Phe His 
            340                 345                 350         


Val Asn Met Gly Lys Leu Arg Tyr Leu Phe Ser Pro Asn Lys Leu Cys 
        355                 360                 365             


Ile Asp Asn Gln Glu Arg Val Arg Met Leu Glu His Leu Leu Asn Gly 
    370                 375                 380                 


Tyr Gly Arg Ile Asp Glu Val Glu Tyr Leu Arg Lys Ala Pro Asn Gly 
385                 390                 395                 400 


Thr Phe Gly Asn Thr Asn Ile Pro Ile Lys Gly Phe Gly Glu Ile Glu 
                405                 410                 415     


Arg Asp Ser Ala Asp Ser Asn Asn Tyr Pro Tyr Ile Val Asp Thr His 
            420                 425                 430         


Thr His Tyr Ile Leu Asn Asn Asn Lys Val Glu Phe Cys Phe Cys Glu 
        435                 440                 445             


Asp Ser Lys Asn Lys Asn Val Phe Pro Thr Ile Glu Lys Glu Ile Asn 
    450                 455                 460                 


Gly Lys Trp Tyr Val Glu Lys Thr Ala Pro His Cys Arg Ile Ser Phe 
465                 470                 475                 480 


Phe Glu Ile Pro Ala Met Ala Phe His Met Phe Leu Cys Gly Ser Glu 
                485                 490                 495     


Lys Thr Glu Lys Leu Ile Lys Asp Val Tyr Asn Asn Tyr Ile Ser Leu 
            500                 505                 510         


Phe Asn Ala Leu Lys Asn Gly Ala Leu Thr Glu Glu Asn Tyr Lys Asp 
        515                 520                 525             


Phe Asn Ile Pro Glu Cys Asp Met Pro Lys Lys Ile Leu Asp Phe Leu 
    530                 535                 540                 


Lys Gly Lys Ala Glu Gly Lys Ser Ile Asp Gly Tyr Val Lys Asn Ile 
545                 550                 555                 560 


Leu Lys Lys Glu Leu Lys Asp Thr Arg Lys Arg Ile Glu Gln Ala Pro 
                565                 570                 575     


Ser Glu Lys Asp Gln Met Pro Ser Lys Arg Asn Lys Ile Gly Thr Lys 
            580                 585                 590         


Ser Tyr Lys Arg Val Leu Thr Gly Lys Leu Ala Asp Phe Leu Ala Lys 
        595                 600                 605             


Asp Ile Val Lys Tyr Gln Pro Thr Leu Cys Ala Gly Asp Asp Tyr Gly 
    610                 615                 620                 


Ile Asp Arg Met Thr Gly Met Asn Tyr Arg Ile Met Gln Ala Thr Ile 
625                 630                 635                 640 


Ala Thr Tyr Asn Asp Asp Asp Asp Phe Asp Thr Phe Tyr Asn Val Phe 
                645                 650                 655     


Lys Met Ala Gly Leu Val Asp Gly Asp Glu Arg Lys Asn His Pro Phe 
            660                 665                 670         


Leu Lys Lys Val Leu Leu Ser Lys Pro Gln Asn Thr Val Ala Phe Asn 
        675                 680                 685             


Ile Lys Tyr Leu Lys Glu Lys Glu Ile Tyr Leu Arg Asn Ile Glu Lys 
    690                 695                 700                 


Lys Asn Ile Ile Pro Pro Phe Val Asn Arg Glu Arg Asn Lys Trp Cys 
705                 710                 715                 720 


Glu Arg Asp Cys Glu Tyr Tyr Arg Ile Leu Gly Glu Asn Leu Leu Asp 
                725                 730                 735     


Leu Pro Ile Glu Leu Pro Arg Gln Met Phe Tyr Lys Asp Ile Arg Ala 
            740                 745                 750         


Gln Leu Glu Pro Leu Met Pro Glu Ile Asp Phe Ser Gln Thr Asn Thr 
        755                 760                 765             


Thr Tyr Leu Ile Ala Glu Tyr Leu Lys Arg Val Arg Gly Asp Asp Phe 
    770                 775                 780                 


Gln Glu Phe Tyr Ser Trp Glu Arg Asn Tyr Arg Tyr Ile Asp Phe Leu 
785                 790                 795                 800 


Lys Cys Ile Arg Asp Asp Asn Gly Arg Ile Cys Ala Gln Tyr Thr Thr 
                805                 810                 815     


Thr Glu Glu Arg Glu Ser Leu Trp Glu Asp Ser Lys Asn Arg Thr Ala 
            820                 825                 830         


Glu Tyr Lys Arg Ser Glu Glu Gln Lys Asn Glu Lys Lys Asp Lys Asn 
        835                 840                 845             


Phe Glu Asp Ser Leu Glu Glu Arg Ile Ser Ser Ser His Ile Lys Phe 
    850                 855                 860                 


Gln Asn Thr Glu Lys His Ile Arg Arg Tyr Lys Val Gln Asp Ala Leu 
865                 870                 875                 880 


Leu Phe Met Ile Ala Glu Lys Gln Phe Gly Lys Tyr Leu Asp Asp Ile 
                885                 890                 895     


Lys Ala Lys Asn Phe Lys Leu Lys Asp Ile Met Pro Asp Thr Asp Lys 
            900                 905                 910         


Gly Ile Leu Ser Glu Thr Met Pro Ile Asp Phe Thr Phe Thr Lys Lys 
        915                 920                 925             


Asn Ile Lys Tyr Asn Ile His Ala Lys Asn Leu Lys Phe Lys Glu Tyr 
    930                 935                 940                 


Gly Asp Leu Phe Ile Leu Ala Asn Asp Lys Arg Leu Glu Ser Leu Trp 
945                 950                 955                 960 


Lys Ile Leu Ala Thr Asp Thr Val Asn Lys Glu Glu Ile Ser Glu Glu 
                965                 970                 975     


Phe Ala Lys Tyr Asp Phe Cys Arg Pro Asp Ile Thr Lys Leu Val Leu 
            980                 985                 990         


Asp Phe Glu Lys Asp Val Leu Glu  Lys Tyr Pro Glu Ile  Ile Glu Glu 
        995                 1000                 1005             


Ala Glu  Lys Glu Tyr Lys Lys  Phe Asp Phe Lys Phe  Ile Leu Asp 
    1010                 1015                 1020             


Trp Leu  Ile Asn Lys Lys Lys  Leu Asn Tyr Gly Ile  Arg Asn Lys 
    1025                 1030                 1035             


Leu Leu  Leu Ile Arg Asn Ala  Phe Asn His Asn Ser  Tyr Pro Asp 
    1040                 1045                 1050             


Lys Lys  Tyr Ala Glu Val Arg  Glu Leu Pro Glu Ile  Ala Thr Asn 
    1055                 1060                 1065             


Leu Lys  Lys Thr Phe Asp Glu  Asn Ala Lys Lys Tyr  Glu 
    1070                 1075                 1080     


<210>  1842
<211>  1140
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1842

Met Glu Asn Asp Gln Gln Ile Leu Glu Asn Arg Arg Arg Thr Leu Ala 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Ser Asn His Leu Ala Ala Ser Phe Glu Gln Lys Val 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ala Ser Phe Leu Cys Asn Lys Ser 
    50                  55                  60                  


Ile Lys Lys Ile Asn Trp Asn His Val Tyr Ser Lys Ala Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ala Asp Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Arg Glu Thr Thr Asp Lys Glu Gly Lys Asp Phe Thr Ala Met Asn Glu 
            100                 105                 110         


Thr Leu Lys Leu Val Phe Asp Glu Leu Gln Ala Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Ala Asp Ser Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Val Glu Leu Ala Asp Phe Leu Thr Val Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Ala Asp Asp Asp Tyr 
                165                 170                 175     


Thr Met Val Glu Ser Lys Gln Ile Val Thr Pro Asp Asn Leu Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Val Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Leu Ala Tyr Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asp Leu Gly Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Glu 
            260                 265                 270         


Val Ile Thr Glu Glu Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Glu Glu Glu Arg 
    290                 295                 300                 


Glu Lys Ile Leu Asp Glu Ile Asp Tyr Glu Asp Tyr Ile Glu Ser Leu 
305                 310                 315                 320 


Thr Arg Arg Val Arg His Ser Asn Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Lys Tyr Asn Lys Gln Phe Asp Gly Glu 
        355                 360                 365             


Ala Thr Glu Cys Lys Val Val Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asn Gln Glu Thr Val Glu Leu Lys Ile Asp Ser Ala 
385                 390                 395                 400 


Gln Arg Thr Asn Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Glu Ala Arg Leu Leu 
            420                 425                 430         


Thr Lys Ala Lys Pro Glu Ser Lys Val Ser Tyr Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Lys Ala Glu Glu Met Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Lys Val Asn Asp Ser Gln Leu Met Ser Met Gln Phe Ile Asp Glu 
                485                 490                 495     


Ile Lys Glu Gln Leu Pro Ala Asp Trp Asn Glu Phe Gly Lys Arg Ser 
            500                 505                 510         


Asp Ser Lys Lys Lys Lys Ala Tyr Thr Asn Ala Ala Leu Gln Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Lys Val Leu Ala Asn Tyr Gln Leu 
    530                 535                 540                 


Asn Asp Lys Gln Val Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Ser Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Val Glu Lys His Lys Leu 
            580                 585                 590         


Asp Lys Ser Ala Arg Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Thr Asp Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Phe Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Tyr 
625                 630                 635                 640 


Ala Asp Thr Asp Lys Lys Ala Thr Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Lys Gly Gly His Pro Phe Leu Ala Asn Ile Asn 
            660                 665                 670         


Leu Arg Gln Ile Arg Lys Thr Ser Gln Leu Tyr Glu Leu Tyr Leu Val 
        675                 680                 685             


Glu Lys Ala Asn Lys Gln Val Lys Lys Met Asn Pro Lys Thr Gln Arg 
    690                 695                 700                 


Thr Ser Asn Val Asp Glu Ser Trp Met Met Lys Ser Phe Tyr Ala Lys 
705                 710                 715                 720 


Glu Trp Asn Glu Glu Met Gly Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Val Asn Lys Thr Asn Ile Pro Phe Thr Ile Arg Gln Trp Glu Glu Lys 
            740                 745                 750         


Glu Lys His Asn Leu Gln Ala Trp Leu His Asn Ile Thr Lys Gly Lys 
        755                 760                 765             


Thr Ser Lys Asp Gly Lys Lys Ala Ile Asp Leu Pro Thr Asn Leu Phe 
    770                 775                 780                 


Asp Asp Thr Leu Cys Glu Leu Leu Arg Glu Ala Leu Ile Asn Gln Gly 
785                 790                 795                 800 


Ile Asp Ala Thr Pro Thr Thr Lys Tyr Asn Glu Leu Leu Lys Gln Trp 
                805                 810                 815     


Trp Thr Ala Arg Glu Asp Ser Thr Gln Asp Phe Tyr Leu Ser Glu Arg 
            820                 825                 830         


Gln Tyr Asp Ile Tyr Asp Glu Lys Val Cys Phe Thr Ile Asn Ser Ser 
        835                 840                 845             


Ala His Phe Ala Asp Tyr Tyr Ala Pro Ala Leu Asn Lys Ala Tyr Ser 
    850                 855                 860                 


Arg Leu Arg Ala Glu Arg Asp Val Ala Arg Arg Thr Asp Lys Arg Leu 
865                 870                 875                 880 


Pro Pro Val Glu Arg Lys Asp Val Glu Arg Val Phe Lys Asn Thr Ile 
                885                 890                 895     


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
            900                 905                 910         


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asn Gln Gln Gln Leu Lys 
        915                 920                 925             


Leu Ser Lys Met Asp Ser Leu Leu Asn Glu Thr Lys Arg Ile Glu Gln 
    930                 935                 940                 


Thr Ile Asn Thr Gln Leu Ser Phe Asp His Lys Gly Lys Glu Ile Lys 
945                 950                 955                 960 


Asp Lys Thr Asn Ser Glu Ile Val Lys Thr Ile Val Ala Glu Arg Lys 
                965                 970                 975     


Gln Lys Asn Tyr Thr Glu Met Arg Lys Tyr Val His Asp Arg Arg Leu 
            980                 985                 990         


Pro Glu Leu Phe Glu Tyr Ile Asp  Gly Asn Glu Leu Pro  Leu Asp Val 
        995                 1000                 1005             


Leu Leu  Asn Glu Leu Arg Ala  Tyr Asn Thr Ala Lys  Gln Met Val 
    1010                 1015                 1020             


Phe Asp  Thr Val Phe Ala Leu  Glu Lys Lys Ile Ile  Glu Thr Asp 
    1025                 1030                 1035             


Pro Glu  Gly Leu Lys Gln Leu  Asn Val Gly Lys Asn  Gly Gln Ile 
    1040                 1045                 1050             


Gln Thr  Gly Asn Ile Gln His  Lys Pro Tyr Val Gln  Trp Leu Glu 
    1055                 1060                 1065             


Asn Lys  Gly Leu Ile Thr Asp  His Gln Lys Gln Phe  Ile Asn Met 
    1070                 1075                 1080             


Val Arg  Asn Ser Phe Ser His  Asn Gln Phe Pro Gln  Arg Ser Thr 
    1085                 1090                 1095             


Val Glu  Leu Leu Met Pro Glu  Trp Gln Asn Thr Asp  Ile Ala Leu 
    1100                 1105                 1110             


Gln Ile  Ala Arg Glu Tyr Gln  Gln Leu Ile Val Asp  Ile Ile Glu 
    1115                 1120                 1125             


Lys Ser  Leu His Pro His Lys  Gln His Gln Met Val  
    1130                 1135                 1140 


<210>  1843
<211>  1146
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1843

Met Glu Ser Ile Ile Gly Leu Gly Leu Ser Phe Asn Pro Tyr Lys Thr 
1               5                   10                  15      


Ala Asp Lys His Tyr Phe Gly Ser Phe Leu Asn Leu Ala Asp Asn Asn 
            20                  25                  30          


Leu Lys Ala Val Phe Ala Glu Phe Lys Glu Arg Ile Ser Asp Lys Ser 
        35                  40                  45              


Lys Asp Glu Asp Ile Ser Asn Leu Ile Glu Lys His Phe Ile Asp Asn 
    50                  55                  60                  


Met Ser Ile Val Asp Tyr Glu Lys Asn Ile Ser Ile Leu Asn Gly Tyr 
65                  70                  75                  80  


Leu Pro Ile Ile Asp Phe Leu Asp Asp Glu Leu Glu Asn Asn Leu Asn 
                85                  90                  95      


Thr Arg Val Lys Asn Phe Lys Lys Ser Phe Ile Ile Leu Ala Glu Ala 
            100                 105                 110         


Leu Glu Thr Leu Arg Asn Tyr Tyr Thr His Phe Tyr His Asp Pro Ile 
        115                 120                 125             


Thr Phe Gly Asp Asn Lys Glu Pro Leu Leu Glu Leu Leu Asp Glu Val 
    130                 135                 140                 


Leu Leu Lys Thr Ile Leu Asp Val Lys Lys Lys Tyr Leu Lys Thr Asp 
145                 150                 155                 160 


Lys Thr Lys Glu Ile Leu Lys Asp Ser Leu Arg Glu Glu Met Asp Leu 
                165                 170                 175     


Leu Val Ile Arg Lys Thr Asp Glu Leu Arg Glu Lys Lys Lys Thr Asn 
            180                 185                 190         


Pro Lys Phe Lys Phe Ser Thr Asp Pro Thr Gln Ile Arg Asn Ser Ile 
        195                 200                 205             


Phe Asn Asp Ala Phe Gln Gly Leu Leu Tyr Glu Asp Lys Glu Asn Asn 
    210                 215                 220                 


Gly Lys Thr Gln Val Ser Tyr Arg Ala Lys Thr Lys Leu Asn Pro Lys 
225                 230                 235                 240 


Asp Ile His Lys Gln Glu Glu Arg Asp Phe Glu Ile Pro Leu Ser Thr 
                245                 250                 255     


Ser Gly Ile Val Phe Leu Met Ser Leu Phe Leu Ser Lys Lys Glu Ile 
            260                 265                 270         


Glu Asp Phe Lys Ser Asn Ile Lys Gly Phe Lys Gly Lys Val Val Lys 
        275                 280                 285             


Asp Glu Asn His Asn Ser Leu Lys Tyr Met Ala Thr His Arg Val Tyr 
    290                 295                 300                 


Ser Ile Leu Ala Phe Lys Gly Leu Lys Tyr Arg Ile Lys Thr Asp Thr 
305                 310                 315                 320 


Phe Ser Lys Val Thr Leu Met Met Gln Met Ile Asp Glu Leu Ser Lys 
                325                 330                 335     


Val Pro Asp Cys Val Tyr Gln Asn Leu Ser Glu Thr Lys Gln Lys Asp 
            340                 345                 350         


Phe Ile Glu Asp Trp Asn Glu Tyr Leu Lys Asp Asn Glu Glu Asn Thr 
        355                 360                 365             


Glu Asn Leu Glu Asn Ser Arg Val Val His Pro Leu Ile Arg Lys Arg 
    370                 375                 380                 


Tyr Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe 
385                 390                 395                 400 


Ala Asn Phe Lys Thr Leu Lys Phe Gln Val Phe Met Gly Tyr Tyr Ile 
                405                 410                 415     


His Asp Gln Arg Thr Lys Thr Ile Gly Thr Thr Asn Ile Thr Thr Glu 
            420                 425                 430         


Arg Thr Val Lys Glu Lys Ile Asn Val Phe Gly Lys Leu Ser Lys Met 
        435                 440                 445             


Asp Asn Leu Lys Lys His Phe Phe Ser Gln Leu Ser Asp Glu Glu Asn 
    450                 455                 460                 


Thr Asp Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Phe Leu Thr Gln 
465                 470                 475                 480 


Ala Asp Asn Ser Pro Ala Asn Asn Ile Pro Ile Tyr Leu Glu Leu Lys 
                485                 490                 495     


Asn Gln Gln Ile Ile Lys Glu Lys Asp Asp Ile Lys Ala Glu Val Asn 
            500                 505                 510         


Asn Ser Gln Asn Arg Asn Pro Asn Lys Pro Ser Lys Arg Asp Leu Leu 
        515                 520                 525             


Asn Lys Ile Ser Asn Thr Asn Glu Asp Phe Tyr Gln Gly Asp Pro Thr 
    530                 535                 540                 


Ala Ile Leu Ser Leu Asn Glu Ile Pro Ala Leu Leu His Leu Phe Leu 
545                 550                 555                 560 


Val Gln Pro Asp Asn Lys Thr Gly Gln Gln Ile Glu Asn Ile Ile Arg 
                565                 570                 575     


Ile Lys Ile Glu Lys Gln Phe Asn Ser Ile Lys Asn Pro Ser Lys Asp 
            580                 585                 590         


Asp Lys Gly Val Pro Lys Ser Leu Phe Ala Asp Thr Asn Val Arg Val 
        595                 600                 605             


Asn Ala Ile Lys Leu Lys Lys Asp Leu Gly Glu Glu Leu Asp Met Leu 
    610                 615                 620                 


Asn Lys Lys Gln Ile Val Phe Lys Glu Asn Gln Lys Ala Ser Ser Asn 
625                 630                 635                 640 


Tyr Asp Glu Leu Leu Lys Lys His Gln Phe Thr Pro Lys Asn Lys Arg 
                645                 650                 655     


Pro Ala Leu Arg Lys Tyr Val Phe Tyr Asn Ser Glu Lys Gly Glu Glu 
            660                 665                 670         


Ala Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Lys Gly Phe 
        675                 680                 685             


Lys Thr Lys Trp Lys Gly Tyr Gln His Ser Glu Leu Gln Arg Lys Leu 
    690                 695                 700                 


Ala Phe Tyr Asp Arg His Thr Lys Gln Asp Ile Lys Glu Leu Leu Ser 
705                 710                 715                 720 


Gly Cys Glu Phe Asp His Phe Leu Leu Asp Ile Asn Ala Cys Phe Lys 
                725                 730                 735     


Glu Asp Asp Phe Glu Asp Phe Phe Ser Lys Tyr Leu Lys Asn Arg Ile 
            740                 745                 750         


Glu Thr Leu Asn Ile Ile Leu Lys Gln Leu His Asp Phe Lys Asn Glu 
        755                 760                 765             


Pro Thr Pro Leu Lys Gly Val Phe Lys Asn Cys Leu Lys Phe Leu Lys 
    770                 775                 780                 


Gln Lys Asn Tyr Val Thr Glu Asn Pro Glu Ile Ile Lys Lys Arg Ile 
785                 790                 795                 800 


Leu Ala Lys Pro Ala Phe Leu Pro Arg Gly Ile Phe Asp Glu Arg Pro 
                805                 810                 815     


Thr Met Lys Lys Gly Lys Asn Pro Leu Ile Asp Arg Asp Glu Phe Ala 
            820                 825                 830         


Lys Trp Phe Val Glu Tyr Leu Glu Asn Lys Asp Tyr Gln Lys Phe Tyr 
        835                 840                 845             


Asn Ser Glu Glu Tyr Arg Ile Arg Asp Ala Asp Phe Lys Lys Asn Ala 
    850                 855                 860                 


Val Ile Lys Lys Gln Lys Leu Lys Asp Phe Tyr Thr Leu Gln Met Val 
865                 870                 875                 880 


Asn Tyr Leu Leu Lys Glu Val Phe Gly Lys Asp Glu Met Asn Leu Gln 
                885                 890                 895     


Leu Ser Glu Leu Phe Gln Thr Arg Gln Glu Arg Leu Lys Leu Gln Gly 
            900                 905                 910         


Ile Ala Lys Lys Gln Met Asn Lys Glu Thr Gly Asp Ser Ser Glu Asn 
        915                 920                 925             


Thr Arg Asn Gln Thr Tyr Ile Trp Asn Lys Asp Val Pro Val Ser Phe 
    930                 935                 940                 


Phe Asn Gly Lys Val Thr Ile Asp Lys Val Lys Leu Lys Asn Ile Gly 
945                 950                 955                 960 


Lys Tyr Lys Arg Tyr Glu Arg Asp Glu Arg Val Lys Thr Phe Ile Gly 
                965                 970                 975     


Tyr Glu Val Asp Glu Lys Trp Met Met Tyr Leu Pro His Asn Trp Lys 
            980                 985                 990         


Asp Arg Tyr Ser Val Lys Pro Ile  Asn Val Ile Asp Leu  Gln Ile Gln 
        995                 1000                 1005             


Glu Tyr  Glu Glu Ile Arg Ser  His Glu Leu Leu Lys  Glu Ile Gln 
    1010                 1015                 1020             


Asn Leu  Glu Gln Tyr Ile Tyr  Asp His Thr Thr Asp  Lys Asn Thr 
    1025                 1030                 1035             


Leu Leu  Gln Asp Gly Asn Pro  Asn Phe Lys Met Tyr  Val Leu Asn 
    1040                 1045                 1050             


Gly Leu  Leu Thr Gly Ile Lys  Gln Val Asn Ile Ala  Asp Phe Ile 
    1055                 1060                 1065             


Val Leu  Lys Gln Asn Thr Asn  Phe Asp Lys Ile Asp  Phe Thr Gly 
    1070                 1075                 1080             


Ile Ala  Ser Cys Ser Glu Leu  Glu Lys Lys Thr Ile  Ile Leu Ile 
    1085                 1090                 1095             


Ala Ile  Arg Asn Lys Phe Ala  His Asn Gln Leu Pro  Asn Lys Thr 
    1100                 1105                 1110             


Ile Tyr  Asp Leu Ala Asn Glu  Phe Leu Lys Lys Glu  Lys Arg Glu 
    1115                 1120                 1125             


Thr Tyr  Ala Asn Tyr Tyr Leu  Lys Val Leu Lys Lys  Met Ile Ser 
    1130                 1135                 1140             


Asp Leu  Ala 
    1145     


<210>  1844
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1844

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Thr 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1845
<211>  1225
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1845

Met Glu Asn Lys Thr Ser Leu Gly Asn Asn Ile Tyr Tyr Asn Ser Phe 
1               5                   10                  15      


Lys Pro Gln Asp Lys Ser Tyr Phe Ala Gly Tyr Leu Asn Ala Ala Met 
            20                  25                  30          


Glu Asn Met Asp Ser Val Phe Arg Glu Leu Gly Lys Arg Leu Lys Gly 
        35                  40                  45              


Lys Glu Tyr Thr Ser Glu Asn Phe Phe Asp Ala Ile Phe Lys Glu Asn 
    50                  55                  60                  


Ile Ser Leu Val Glu Tyr Glu Arg Tyr Val Lys Leu Leu Ser Asp Tyr 
65                  70                  75                  80  


Phe Pro Met Val Arg Leu Leu Asp Lys Lys Glu Val Pro Ile Lys Glu 
                85                  90                  95      


Arg Lys Glu Asn Phe Lys Lys Asn Phe Lys Gly Ile Ile Lys Ala Val 
            100                 105                 110         


Arg Asp Leu Arg Asn Phe Tyr Thr His Lys Glu His Gly Lys Val Glu 
        115                 120                 125             


Ile Pro Asp Glu Ile Phe Ala Val Leu Asp Glu Met Leu Lys Ser Thr 
    130                 135                 140                 


Val Leu Thr Val Lys Lys Lys Lys Val Lys Thr Asp Lys Thr Lys Glu 
145                 150                 155                 160 


Ile Leu Lys Lys Ser Ile Glu Lys Gln Leu Asp Ile Leu Cys Gln Lys 
                165                 170                 175     


Lys Leu Asn Tyr Leu Arg Glu Thr Ala Glu Lys Ile Glu Glu Lys Arg 
            180                 185                 190         


Arg Asn Gln Arg Glu Arg Gly Glu Arg Lys Leu Val Pro Pro Phe Lys 
        195                 200                 205             


Tyr Ser Asp Lys Arg Asp Asp Leu Ile Ala Ala Ile Tyr Asn Asp Ala 
    210                 215                 220                 


Phe Asp Phe Tyr Ile Asn Lys Lys Lys Asp Ser Leu Lys Glu Ser Ser 
225                 230                 235                 240 


Lys Thr Lys Tyr Asn Thr Glu Ser Tyr Pro Gln Gln Glu Lys Gly Asp 
                245                 250                 255     


Leu Glu Ile Pro Ile Ser Lys Asn Gly Val Val Phe Leu Leu Ser Leu 
            260                 265                 270         


Phe Leu Thr Lys Gln Glu Ile His Ala Phe Lys Ser Lys Ile Ala Gly 
        275                 280                 285             


Phe Lys Ala Thr Val Ile Asp Glu Ala Thr Val Ser Glu Ala Thr Val 
    290                 295                 300                 


Ser His Arg Lys Asn Ser Ile Cys Phe Met Ala Thr His Glu Ile Phe 
305                 310                 315                 320 


Ser His Leu Ala Tyr Lys Lys Leu Lys Arg Lys Val Arg Thr Ala Glu 
                325                 330                 335     


Ile Asn Tyr Gly Glu Ala Glu Asn Ala Glu Gln Leu Ser Ile Tyr Ala 
            340                 345                 350         


Lys Glu Thr Leu Met Met Gln Met Leu Asp Glu Leu Ser Lys Val Pro 
        355                 360                 365             


Asp Val Val Tyr Gln Asn Leu Ser Glu Asp Val Gln Lys Thr Phe Ile 
    370                 375                 380                 


Glu Asp Trp Asn Glu Tyr Leu Lys Glu Asn Asn Ser Asp Val Gly Thr 
385                 390                 395                 400 


Met Glu Glu Glu Gln Val Ile His Pro Met Ile Arg Lys Arg Tyr Glu 
                405                 410                 415     


Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe Ala Gln 
            420                 425                 430         


Phe Pro Thr Leu Arg Phe Gln Val His Leu Gly Asp Tyr Leu His Asp 
        435                 440                 445             


Ser Arg Pro Lys Glu His Leu Ile Ser Asp Arg Arg Ile Lys Glu Lys 
    450                 455                 460                 


Ile Thr Val Phe Gly Arg Leu Ser Glu Leu Glu His Lys Lys Ala Leu 
465                 470                 475                 480 


Phe Ile Lys Asn Thr Glu Thr Asn Glu Asp Arg Glu His Tyr Trp Glu 
                485                 490                 495     


Val Phe Pro Asn Pro Asn Tyr Asp Phe Pro Lys Glu Asn Ile Ser Val 
            500                 505                 510         


Asn Asp Lys Asp Phe Pro Ile Ala Gly Ser Ile Leu Asp Arg Glu Lys 
        515                 520                 525             


Gln Pro Thr Ala Gly Lys Ile Gly Ile Lys Val Lys Leu Leu Asn Gln 
    530                 535                 540                 


Lys Tyr Ile Ser Glu Val Asp Lys Ala Val Lys Ala Asn Gln Leu Lys 
545                 550                 555                 560 


Gln Arg Lys Ala Asn Lys Pro Ser Ile Gln Asn Ile Ile Glu Glu Ile 
                565                 570                 575     


Val Pro Ile Asn Gly Asn Asn Gln Glu Glu Ile Ile Val Phe Gly Gly 
            580                 585                 590         


Gln Pro Thr Ala Tyr Leu Ser Met Asn Asp Ile His Ser Ile Leu Tyr 
        595                 600                 605             


Glu Phe Phe Asp Lys Trp Glu Glu Lys Lys Glu Lys Leu Glu Lys Lys 
    610                 615                 620                 


Gly Glu Lys Glu Leu Arg Lys Glu Ile Gly Lys Glu Leu Glu Glu Lys 
625                 630                 635                 640 


Ile Val Gly Lys Ile Gln Thr Gln Ile Gln Gln Ile Ile Asp Lys Asp 
                645                 650                 655     


Ile Asn Ala Lys Ile Leu Lys Pro Tyr Gln Asp Asp Asn Ser Thr Val 
            660                 665                 670         


Ile Asp Lys Glu Lys Leu Ile Lys Asp Leu Lys Gln Glu Gln Ser Val 
        675                 680                 685             


Leu Gln Lys Leu Lys Asp Glu Gln Thr Val Arg Glu Lys Glu Tyr Lys 
    690                 695                 700                 


Glu Cys Ile Ala Tyr Gln Asp Lys Asn Arg Glu Ile Asn Lys Val Arg 
705                 710                 715                 720 


Asp Arg Asn His Lys Gln Tyr Leu Arg Asn Gln Leu Arg Arg Lys Tyr 
                725                 730                 735     


Pro Glu Val Pro Ala Arg Lys Glu Val Leu Tyr Tyr Arg Glu Lys Gly 
            740                 745                 750         


Lys Val Ala Val Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Thr 
        755                 760                 765             


Asp Phe Lys Asn Glu Trp Lys Gly Glu Gln His Ser Leu Leu Gln Lys 
    770                 775                 780                 


Ser Leu Ala Tyr Tyr Glu Gln Cys Lys Glu Glu Leu Arg Thr Leu Leu 
785                 790                 795                 800 


Pro Gln Glu Lys Val Phe Lys His Leu Pro Phe Glu Leu Gly Gly His 
                805                 810                 815     


Phe Gln Gln Lys Tyr Leu Tyr Gln Phe Tyr Thr Arg Tyr Leu Asp Lys 
            820                 825                 830         


Arg Leu Glu His Ile Ser Gly Leu Val Gln Gln Ala Glu Asn Phe Lys 
        835                 840                 845             


Asn Glu Asn Lys Val Phe Lys Lys Val Glu Asn Glu Cys Phe Lys Phe 
    850                 855                 860                 


Leu Lys Lys Gln Asn Tyr Ile His Lys Glu Leu Asp Ala Gln Val Gln 
865                 870                 875                 880 


Ser Ile Leu Gly Tyr Pro Ile Phe Leu Lys Arg Gly Phe Met Asn Glu 
                885                 890                 895     


Lys Pro Thr Ile Ile Lys Gly Lys Thr Phe Lys Gly Asn Glu Ala Leu 
            900                 905                 910         


Phe Ala His Trp Phe Lys Tyr Tyr Lys Glu Tyr Gln Asn Phe Gln Thr 
        915                 920                 925             


Phe Tyr Asp Thr Glu Asn Tyr Pro Leu Val Lys Leu Glu Lys Lys Gln 
    930                 935                 940                 


Ala Asp Arg Lys Arg Lys Thr Lys Ile Tyr Gln Gln Lys Lys Asn Asp 
945                 950                 955                 960 


Val Phe Thr Leu Leu Met Ala Lys His Ile Phe Lys Ser Val Phe Lys 
                965                 970                 975     


Gln Asp Ser Ile Asp Arg Phe Ser Leu Glu Asp Leu Tyr Gln Ser Arg 
            980                 985                 990         


Glu Glu Arg Leu Glu Asn Gln Glu  Lys Ala Lys Gln Thr  Gly Glu Arg 
        995                 1000                 1005             


Asn Thr  Asn Tyr Ile Trp Asn  Lys Thr Val Asp Leu  Asn Leu Cys 
    1010                 1015                 1020             


Asp Gly  Lys Ile Thr Val Glu  Asn Val Lys Leu Lys  Asn Val Gly 
    1025                 1030                 1035             


Asn Phe  Ile Lys Tyr Glu Tyr  Asp Gln Arg Val Gln  Ala Phe Leu 
    1040                 1045                 1050             


Thr Tyr  Glu Glu Asn Ile Lys  Trp Gln Ala Phe Leu  Ile Lys Glu 
    1055                 1060                 1065             


Ser Lys  Glu Glu Glu Asn Tyr  Pro Tyr Val Val Glu  Arg Glu Ile 
    1070                 1075                 1080             


Glu Gln  Tyr Glu Lys Val Arg  Arg Glu Glu Leu Leu  Lys Glu Val 
    1085                 1090                 1095             


His Leu  Ile Glu Glu Tyr Ile  Leu Glu Lys Val Lys  Asp Lys Glu 
    1100                 1105                 1110             


Ile Leu  Lys Lys Gly Asp Asn  Gln Asn Phe Lys Tyr  Tyr Ile Leu 
    1115                 1120                 1125             


Asn Gly  Leu Leu Lys Gln Phe  Lys Asn Glu Asn Val  Asp Gly Tyr 
    1130                 1135                 1140             


Lys Val  Phe Asn Leu Asp Thr  Lys Pro Glu Asp Val  Asp Ile Asn 
    1145                 1150                 1155             


Gln Leu  Lys Gln Glu Ala Thr  Asp Leu Glu Gln Lys  Ala Phe Val 
    1160                 1165                 1170             


Leu Thr  Tyr Ile Arg Asn Lys  Phe Ala His Asn Gln  Leu Pro Lys 
    1175                 1180                 1185             


Lys Glu  Phe Trp Asp Tyr Cys  Gln Glu Lys Cys Gly  Lys Ile Ala 
    1190                 1195                 1200             


Lys Gly  Lys Thr Tyr Ala Glu  Tyr Phe Ala Glu Val  Phe Lys Arg 
    1205                 1210                 1215             


Glu Lys  Glu Ala Leu Met Lys  
    1220                 1225 


<210>  1846
<211>  1202
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1846

Met Glu Asn Lys Thr Ser Leu Gly Asn Asn Ile Tyr Tyr Asn Pro Phe 
1               5                   10                  15      


Lys Pro Gln Asp Lys Pro Tyr Phe Ala Gly Tyr Leu Asn Ala Ala Met 
            20                  25                  30          


Glu Asn Ile Asp Ser Val Phe Arg Glu Leu Gly Lys Arg Leu Lys Gly 
        35                  40                  45              


Lys Glu Tyr Thr Ser Glu Asn Phe Phe Asp Ala Ile Phe Lys Glu Asn 
    50                  55                  60                  


Ile Ser Leu Val Glu Tyr Glu Arg Tyr Val Lys Leu Leu Ser Asp Tyr 
65                  70                  75                  80  


Phe Pro Met Ala Arg Leu Leu Asp Lys Lys Glu Ala Pro Ile Lys Glu 
                85                  90                  95      


Arg Lys Glu Asn Phe Lys Lys Asn Phe Lys Gly Ile Ile Lys Ala Val 
            100                 105                 110         


Arg Asp Leu Arg Asn Phe Tyr Thr His Lys Glu His Gly Glu Val Glu 
        115                 120                 125             


Ile Thr Asp Glu Ile Phe Gly Val Leu Asp Glu Met Leu Lys Ser Thr 
    130                 135                 140                 


Val Leu Thr Val Lys Lys Lys Lys Val Lys Thr Asp Lys Thr Lys Glu 
145                 150                 155                 160 


Ile Leu Lys Lys Ser Ile Glu Lys Gln Leu Asp Ile Leu Cys Gln Lys 
                165                 170                 175     


Lys Leu Glu Tyr Leu Arg Asp Thr Ala Arg Lys Ile Glu Glu Lys Arg 
            180                 185                 190         


Arg Asn Gln Arg Glu Arg Gly Glu Asp Ile Asp Pro Pro Phe Arg Tyr 
        195                 200                 205             


Gly Asp Lys Arg Glu Asp Leu Ile Ala Ala Ile Tyr Asn Asp Ala Phe 
    210                 215                 220                 


Asp Phe Tyr Ile Asp Lys Lys Lys Asp Ser Leu Lys Glu Ser Ile Lys 
225                 230                 235                 240 


Ala Lys Tyr Asn Thr Lys Ser Tyr Pro Gln Gln Glu Glu Gly Asp Leu 
                245                 250                 255     


Lys Ile Pro Ile Ser Lys Asn Gly Val Val Phe Leu Leu Ser Leu Phe 
            260                 265                 270         


Leu Thr Lys Gln Glu Ile His Ala Phe Lys Ser Lys Ile Ala Gly Phe 
        275                 280                 285             


Lys Ala Thr Val Ile Asp Glu Ala Thr Val Ser Glu Ala Thr Val Ser 
    290                 295                 300                 


His Arg Lys Asn Ser Ile Cys Phe Met Ala Thr His Glu Ile Phe Ser 
305                 310                 315                 320 


His Leu Ala Tyr Lys Lys Leu Lys Arg Lys Val Arg Thr Ala Glu Ile 
                325                 330                 335     


Asn Tyr Gly Glu Ala Glu Asn Ala Glu Gln Leu Ser Ile Tyr Ala Lys 
            340                 345                 350         


Glu Thr Leu Met Met Gln Met Leu Asp Glu Leu Ser Lys Val Pro Asp 
        355                 360                 365             


Val Val Tyr Gln Asn Leu Ser Glu Asp Val Gln Lys Thr Phe Ile Glu 
    370                 375                 380                 


Asp Trp Asn Glu Tyr Leu Lys Glu Asn Asn Gly Asp Val Gly Thr Met 
385                 390                 395                 400 


Glu Glu Glu Gln Val Ile His Pro Val Ile Arg Lys Arg Tyr Glu Asp 
                405                 410                 415     


Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe Ala Gln Phe 
            420                 425                 430         


Pro Thr Leu Arg Phe Gln Val His Leu Gly Asn Tyr Phe His Asp Ser 
        435                 440                 445             


Arg Pro Lys Glu His Leu Ile Ser Asp Arg Arg Ile Lys Glu Lys Ile 
    450                 455                 460                 


Thr Val Phe Gly Arg Leu Ser Glu Leu Glu His Lys Lys Ala Leu Phe 
465                 470                 475                 480 


Ile Lys Asn Thr Glu Thr Asn Glu Asp Arg Lys His Tyr Trp Glu Ile 
                485                 490                 495     


Phe Ser Asn Pro Asn Tyr Asp Phe Pro Lys Glu Asn Ile Ser Val Asn 
            500                 505                 510         


Asp Lys Asp Phe Pro Ile Ala Gly Ser Ile Leu Asp Arg Glu Lys Gln 
        515                 520                 525             


Pro Thr Ala Gly Lys Ile Gly Ile Lys Val Lys Gln Tyr Ile Ser Glu 
    530                 535                 540                 


Val Asp Lys Ala Val Lys Ala Asn Gln Leu Lys Gln Arg Lys Ala Asn 
545                 550                 555                 560 


Lys Pro Ser Ile Gln Asn Ile Ile Glu Glu Ile Val Pro Ile Asn Gly 
                565                 570                 575     


Ser Asn Pro Lys Glu Ile Ile Val Phe Gly Gly Gln Pro Thr Ala Tyr 
            580                 585                 590         


Leu Ser Met Asn Asp Ile His Ser Ile Leu Tyr Glu Phe Leu Ile Lys 
        595                 600                 605             


Gly Thr Ser Gly Glu Ala Leu Glu Lys Lys Ile Val Gly Lys Ile Gln 
    610                 615                 620                 


Thr Gln Ile Gln Gln Ile Ile Asp Lys Asp Thr Asn Ala Lys Ile Leu 
625                 630                 635                 640 


Lys Pro Tyr Gln Asp Glu Ile Ser Thr Ala Ile Asp Lys Glu Lys Leu 
                645                 650                 655     


Ile Lys Asp Leu Lys Gln Glu Gln Asn Ile Leu Gln Lys Leu Lys Asp 
            660                 665                 670         


Glu Gln Thr Val Arg Glu Lys Glu Tyr Asn Asp Phe Ile Ala Tyr Gln 
        675                 680                 685             


Asp Lys Asn Arg Glu Ile Asn Lys Val Arg Asp Arg Asn His Lys Gln 
    690                 695                 700                 


Tyr Leu Lys Asp Asn Leu Lys Arg Lys Tyr Pro Glu Ala Pro Ala Arg 
705                 710                 715                 720 


Lys Glu Ile Leu Tyr Tyr Gln Glu Lys Gly Lys Val Ala Val Trp Leu 
                725                 730                 735     


Ala Asn Asp Ile Lys Arg Phe Met Pro Thr Asp Phe Lys Asn Glu Trp 
            740                 745                 750         


Lys Gly Glu Gln His Ser Leu Leu Gln Lys Ser Leu Ala Tyr Tyr Glu 
        755                 760                 765             


Gln Cys Lys Glu Glu Leu Lys Asn Leu Leu Pro Glu Lys Val Phe Gln 
    770                 775                 780                 


His Leu Pro Phe Lys Leu Gly Gly Tyr Phe Gln Gln Lys Tyr Leu Tyr 
785                 790                 795                 800 


Gln Phe Tyr Thr Cys Tyr Leu Asp Lys Arg Leu Glu Tyr Ile Ser Gly 
                805                 810                 815     


Leu Val Gln Gln Ala Glu Asn Phe Lys Ser Glu Asn Lys Val Phe Lys 
            820                 825                 830         


Lys Val Glu Asn Glu Cys Phe Lys Phe Leu Lys Lys Gln Asn Tyr Thr 
        835                 840                 845             


His Lys Glu Leu Asp Ala Arg Val Gln Ser Ile Leu Gly Tyr Pro Ile 
    850                 855                 860                 


Phe Leu Glu Arg Gly Phe Met Asp Glu Lys Pro Thr Ile Ile Lys Gly 
865                 870                 875                 880 


Lys Thr Phe Lys Gly Asn Glu Ser Leu Phe Ala Asp Trp Phe Lys Tyr 
                885                 890                 895     


Tyr Lys Glu Tyr Gln Asn Phe Gln Thr Phe Tyr Asp Thr Glu Asn Tyr 
            900                 905                 910         


Pro Leu Val Glu Leu Glu Lys Lys Gln Ala Asp Arg Lys Arg Lys Thr 
        915                 920                 925             


Lys Ile Tyr Gln Gln Lys Lys Asn Asp Val Phe Thr Leu Leu Met Ala 
    930                 935                 940                 


Lys His Ile Phe Lys Ser Val Phe Lys Gln Asp Ser Ile Asp Arg Phe 
945                 950                 955                 960 


Ser Leu Glu Asp Leu Tyr Gln Ser Arg Glu Glu Arg Leu Glu Asn Gln 
                965                 970                 975     


Glu Lys Ala Lys Gln Thr Gly Glu Arg Asn Thr Asn Tyr Ile Trp Asn 
            980                 985                 990         


Lys Thr Val Asp Leu Lys Leu Cys  Asp Gly Lys Ile Thr  Val Glu Asn 
        995                 1000                 1005             


Val Lys  Leu Lys Asn Val Gly  Asp Phe Ile Lys Tyr  Glu Tyr Asp 
    1010                 1015                 1020             


Gln Arg  Val Gln Ala Phe Leu  Lys Tyr Glu Glu Asn  Ile Glu Trp 
    1025                 1030                 1035             


Gln Ala  Phe Leu Ile Lys Glu  Ser Lys Glu Glu Glu  Asn Tyr Pro 
    1040                 1045                 1050             


Tyr Val  Val Glu Arg Glu Ile  Glu Gln Tyr Glu Lys  Val Arg Arg 
    1055                 1060                 1065             


Glu Glu  Leu Leu Lys Glu Val  His Leu Ile Glu Glu  Tyr Ile Leu 
    1070                 1075                 1080             


Glu Lys  Val Lys Asp Lys Glu  Ile Leu Lys Lys Gly  Asp Asn Gln 
    1085                 1090                 1095             


Asn Phe  Lys Tyr Tyr Ile Leu  Asn Gly Leu Leu Lys  Gln Leu Lys 
    1100                 1105                 1110             


Asn Glu  Asp Val Glu Ser Tyr  Lys Val Phe Asn Leu  Asn Thr Glu 
    1115                 1120                 1125             


Pro Glu  Gly Val Asn Ile Asn  Gln Leu Lys Gln Glu  Ala Thr Asp 
    1130                 1135                 1140             


Leu Glu  Gln Lys Ala Phe Val  Leu Thr Tyr Ile Arg  Asn Lys Phe 
    1145                 1150                 1155             


Ala His  Asn Gln Leu Pro Lys  Arg Glu Phe Trp Asp  Tyr Cys Gln 
    1160                 1165                 1170             


Glu Lys  Tyr Gly Lys Ile Glu  Lys Glu Lys Thr Tyr  Ala Glu Tyr 
    1175                 1180                 1185             


Phe Ser  Glu Ile Phe Lys Arg  Glu Lys Glu Ala Leu  Ile Lys 
    1190                 1195                 1200         


<210>  1847
<211>  1164
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1847

Met Thr Ala Thr Asn Gly Leu Gly Lys Gly Ile Ser Tyr His His His 
1               5                   10                  15      


Leu Tyr Ala Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Asp 
            20                  25                  30          


Asp Asn Ile Asp Gln Val Lys Gln Leu Phe Asp Thr Arg Phe Gly Glu 
        35                  40                  45              


Lys Asn Ala Asp Arg Phe Phe Ser Thr Lys Asn Asn His Leu Ile Ala 
    50                  55                  60                  


Tyr Asp Asp Trp Glu Lys Gly Ile Asp Phe Leu Lys Gln Tyr Leu Pro 
65                  70                  75                  80  


Val Val His Tyr Leu Ala Leu Pro Val Asn His Glu Lys Phe Ser Asn 
                85                  90                  95      


Leu Thr Asp Lys Glu Lys Gly Arg Arg Asp Tyr Phe Thr Ile His Phe 
            100                 105                 110         


Asn Leu Leu Thr Ser Thr Ile His Asp Cys Arg Asn Phe Tyr Thr His 
        115                 120                 125             


Tyr Tyr His Asp Pro Ile Thr Val Gln Asn Asp Leu Phe Gln Leu Leu 
    130                 135                 140                 


Asp Glu Leu Phe Ile Leu Val Cys Arg Asp Val Arg Lys His Arg Ile 
145                 150                 155                 160 


Lys Thr Asp Lys Thr Gly Trp Leu Leu Lys Arg Thr Leu Gln Asn Glu 
                165                 170                 175     


Leu Gln Ile Leu Thr Lys His Lys Lys His Thr Leu Glu Lys Gln Lys 
            180                 185                 190         


Lys Glu Gly Lys Lys Val Asn Leu Asp Ala Glu Ala Ile Glu Asn Ala 
        195                 200                 205             


Val Met Asn Asp Ala Phe Lys His Leu Arg Tyr Thr Asp Lys Glu Asp 
    210                 215                 220                 


Asn Lys Gly Asn Ile Lys Lys Phe Leu Val Lys Asp Gln Tyr Lys Ser 
225                 230                 235                 240 


Ala Tyr Asn Arg Gln Glu Pro Ser Glu Asn Gly Ile Cys Leu Ser Arg 
                245                 250                 255     


Ser Gly Leu Leu Phe Leu Cys Ser Met Phe Leu Ser Arg Lys Ala Gly 
            260                 265                 270         


Glu Asp Met Arg Ala Arg Val Ser Gly Phe Lys Glu Lys Phe Val Tyr 
        275                 280                 285             


Arg Thr Glu Glu Glu Ile Thr Asp Lys Asn Asn Ser Leu Arg Ser Met 
    290                 295                 300                 


Val Thr Gln Trp Val Phe Ser His Leu Ala Phe Lys Asp Ile Lys Gln 
305                 310                 315                 320 


Arg Ile Thr Thr Asn Leu Asp Arg Glu Thr Leu Phe Val Gln Ile Val 
                325                 330                 335     


Asp Tyr Leu Ser Lys Val Pro Asp Glu Leu Tyr Gln Val Phe Ser Asn 
            340                 345                 350         


Thr Gln Lys Leu Asp Phe Leu Glu Asp Ile Asn Glu Tyr Ile Lys Glu 
        355                 360                 365             


Gly Asn Lys Thr Glu Ser Leu Ile Gln Ser Thr Val Ala His Pro Val 
    370                 375                 380                 


Ile Arg Lys Arg Tyr Glu Asn Gln Phe Asn Tyr Phe Val Leu Arg Tyr 
385                 390                 395                 400 


Leu Asp Glu Phe Val Glu Phe Pro Ser Leu Arg Phe Gln Ile Asn Thr 
                405                 410                 415     


Gly Phe Tyr Thr His Asp Gln Arg Glu Lys Thr Ile Glu Gly Thr Glu 
            420                 425                 430         


Tyr Leu Thr Asp Arg Lys Ile Lys Glu Lys Ile Lys Val Phe Gly Lys 
        435                 440                 445             


Leu Ser Glu Val Thr Thr Gln Lys Asn Glu Phe Leu Val Lys Asn Thr 
    450                 455                 460                 


Asp Leu Gln Gly Trp Glu Ala Tyr Pro Gly Pro Ser Tyr Asn Val Asn 
465                 470                 475                 480 


Asn Asn Asn Ile Pro Val Phe Ile Asn Met Gln Asn Asn Ala Val Asn 
                485                 490                 495     


Gly Ser Lys Gln Trp Tyr Ser Lys Ile Asn Phe Lys Ile Arg Asn Glu 
            500                 505                 510         


Arg Asn Leu Lys Gln Ser Pro Arg Thr Glu Asp Lys Lys Gln Lys Ser 
        515                 520                 525             


Ala Ile Ala Asp Met Leu Lys Ile Asn Gly Glu Met Asp Leu Arg Tyr 
    530                 535                 540                 


Glu Glu Pro Thr Ala Ile Leu Cys Leu Lys Glu Leu Pro Ser Leu Leu 
545                 550                 555                 560 


Tyr Glu Leu Leu Tyr Thr Lys Ala Ser Pro Lys Glu Ile Glu Glu His 
                565                 570                 575     


Leu Leu Lys Lys Ile Ile Gly His Leu Asp Thr Ile Glu Lys Tyr Ala 
            580                 585                 590         


His His Thr Asp Ser Ser Leu Gln Gly Met Pro Arg Lys Leu Lys Lys 
        595                 600                 605             


Ser Gly Glu Glu Ser Ser Ile Asn Tyr Lys Lys Leu Arg Glu Val Ile 
    610                 615                 620                 


Val Asn Glu Leu Lys Val Ile Thr Glu Lys Gln Asp Phe Leu Lys Glu 
625                 630                 635                 640 


Lys Gln Lys Asp Lys Lys Val Asn Lys Arg Leu Tyr Leu Leu Asn Asn 
                645                 650                 655     


Arg Glu Met Gly Lys Glu Ala Thr Trp Leu Ala Ser Asp Leu Ile Arg 
            660                 665                 670         


Phe Met Pro Glu Thr Ala Arg Lys Gln Trp Lys Gly Tyr His His Ser 
        675                 680                 685             


Gln Leu Gln Gln Thr Leu Ala Phe Tyr Gln Gln Lys Arg Lys Glu Ala 
    690                 695                 700                 


Leu Ser Leu Ile Gly Gln Phe Trp Asp Phe Asn Thr Gly Pro Tyr Trp 
705                 710                 715                 720 


Gly Asp Lys Leu Lys Lys Ala Phe Glu Gln Thr Thr Phe Glu Asp Phe 
                725                 730                 735     


Tyr Phe Glu Tyr Leu Lys Met Arg Gln Ala Ile Leu Asn Asn Phe Leu 
            740                 745                 750         


Glu Asn Val Ser Ser Ser Gln Asn Gln Pro Asn Leu Ala Lys Lys Ala 
        755                 760                 765             


Leu Lys Asp Cys Trp Ile Ile Phe His Lys Arg His Phe Ile Ile Arg 
    770                 775                 780                 


Pro Ala Lys Glu Gln Ile Ser Ser Leu Leu Ala Gln Pro Val Val Leu 
785                 790                 795                 800 


Pro Arg Gly Leu Phe Asp Asn Lys Pro Thr Tyr Ile Lys Asp Val Lys 
                805                 810                 815     


Leu Glu Asp Ala Pro Glu Lys Phe Ala Asn Trp Tyr Arg Tyr Thr Tyr 
            820                 825                 830         


Asn Asp Tyr Pro Met Gln Arg Phe Tyr Ser Phe Asp Arg Asp Tyr Thr 
        835                 840                 845             


Ser Leu Tyr Glu Glu Phe Gln Ser Asn Lys Asp Val Ile Leu Asn Lys 
    850                 855                 860                 


Lys Arg Leu Thr Lys Ser Glu Gln Glu Ala Leu Leu Lys Lys Lys Gln 
865                 870                 875                 880 


Asp Leu Lys Ile Lys Asp Ile Arg Thr Gln Asp Leu Phe Leu Lys Leu 
                885                 890                 895     


Ile Ala Asp Lys Leu Phe Glu Asp Ile Phe Asp Gln Lys Ala Asp Phe 
            900                 905                 910         


Thr Leu Glu Asp Ile Tyr Gln Thr Arg Glu Glu Arg Met Gln Asn Gly 
        915                 920                 925             


Glu Gln Ala Leu Gln Gln Ser Glu Arg Ala Pro Gly Asp Asp Phe Glu 
    930                 935                 940                 


Asn Ile Tyr Asn Glu Ser Phe Val Leu Asn Lys Thr Val Pro Phe Ile 
945                 950                 955                 960 


Gln Lys Gln Ile His Glu Pro Thr Val Lys Ile Lys Asp Leu Gly Lys 
                965                 970                 975     


Phe Lys Arg Phe Leu Phe Asp Asn Lys Val Lys Ala Leu Phe Ser Tyr 
            980                 985                 990         


Glu Pro Asn Arg Val Trp Ser Ile  Gln Glu Leu Glu Asn  Glu Leu Thr 
        995                 1000                 1005             


Leu Leu  Pro Thr Ser Tyr Glu  Val Ile Arg Arg Val  Ser Leu Leu 
    1010                 1015                 1020             


Lys Ala  Ile Gln Glu Phe Glu  Lys Tyr Ile Met Glu  Cys Trp Gly 
    1025                 1030                 1035             


Asp Ser  Asp Thr Thr Lys Leu  Asp Gln Lys Asp Lys  Lys Ser Gly 
    1040                 1045                 1050             


Lys Tyr  Asn Pro Ser Phe Lys  Lys Tyr Ile Phe Asn  Gly Val Leu 
    1055                 1060                 1065             


Asp Lys  Phe Arg Leu Ala Asn  Ala Glu Asn Ile Lys  His Ile Ile 
    1070                 1075                 1080             


Asp Tyr  Lys Lys Phe Glu Glu  Leu Val Asp Asp Pro  Gln Leu Lys 
    1085                 1090                 1095             


Ser Phe  Glu Glu Ile Val Arg  Lys Ala Tyr Ile Leu  Thr Ile Ile 
    1100                 1105                 1110             


Arg Asn  Lys Ile Ala His Asn  Gln Leu Pro Asp Lys  Ala Asn Met 
    1115                 1120                 1125             


Asp Phe  Ile Gln Gly Met Tyr  Pro Lys Glu Pro Gln  Asp Ser Tyr 
    1130                 1135                 1140             


Ser Gln  Tyr Leu Leu Arg Val  Thr Gln Leu Ile Ile  Asp Glu Met 
    1145                 1150                 1155             


Val Leu  Leu Met Lys Ile 
    1160                 


<210>  1848
<211>  1130
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1848

Met Glu Thr Leu Ser Ile Ser Lys Val Phe Asn Tyr Arg Thr Leu Asn 
1               5                   10                  15      


Glu Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Thr Met Ser Arg Leu Asn 
            20                  25                  30          


Ile Ile Ser Ile Ser Asn His Ile Ala Asn Glu Phe Gly Leu Pro Leu 
        35                  40                  45              


Leu Glu Glu Glu Gly Gln Leu Lys Asn Ser Phe Leu Cys His Lys Asp 
    50                  55                  60                  


Asn Lys Glu Val Asn Trp Tyr His Val His Ser Lys Thr Lys Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Glu Ala Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Lys Ile Ile Asp Trp Glu Gly Lys Asp Phe Ala Lys Met Cys Asp 
            100                 105                 110         


Thr Leu Asn Thr Val Phe Thr Glu Leu Met Glu Phe Arg Asp Asp Tyr 
        115                 120                 125             


Ser His Phe Tyr Ser Pro Lys Lys Gly Thr Thr Arg Lys Thr Ile Leu 
    130                 135                 140                 


Ser Pro Gly Leu Ala Leu Phe Leu Lys Thr Asn Phe Gly Arg Ala Ile 
145                 150                 155                 160 


Gly Tyr Thr Lys Glu Lys Phe Lys Asp Ile Leu Lys Asp Glu Asp Phe 
                165                 170                 175     


Gln Leu Val Ala Ser Leu Lys Met Phe Glu Ala Asp His Thr Ile Thr 
            180                 185                 190         


Thr Gln Gly Leu Val Phe Leu Thr Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Arg Leu Ile Gly Lys Leu Ala Gly Leu Gln Gly Ile Gln Asn 
    210                 215                 220                 


Ser Ser Phe Ile Ala Thr Cys Glu Val Leu Met Ala Tyr Cys Leu Lys 
225                 230                 235                 240 


Leu Pro Gln Asp Gln Ile Arg Asn Glu Cys Lys Arg Gln Ser Phe Ser 
                245                 250                 255     


Leu Glu Leu Ile Asn Glu Leu Ser Lys Cys Pro Lys Val Leu Tyr His 
            260                 265                 270         


Thr Ile Thr Asp Glu Gly Lys Gln Lys Leu Arg Pro Ala Pro Glu Gln 
        275                 280                 285             


Leu Glu Ala Lys Asn Phe Phe Asp Lys Ser Ser Asn Lys Glu Glu Lys 
    290                 295                 300                 


Ile Glu Ala Glu Asn Tyr Asp Leu Tyr Ile Asp Ser Leu Thr Arg Arg 
305                 310                 315                 320 


Ile Arg Ser Gly Asn Arg Phe Ser Glu Phe Ala Leu Lys Tyr Ile Asp 
                325                 330                 335     


Glu Thr Asp Ile Phe Ser Glu Phe Arg Phe Gln Ile Glu Ile Gly Thr 
            340                 345                 350         


Leu Leu Val Asp Glu Tyr Leu Lys Phe Phe Asn Gly Glu Leu Val Pro 
        355                 360                 365             


Arg Arg Ile Ile Asp Asn Ala Asn Ala Phe Gly Lys Leu Ser Asp Phe 
    370                 375                 380                 


Asn Asp Gln Ser Lys Val Ile Thr Arg Ile Glu Asn Gly His Ser Gln 
385                 390                 395                 400 


Arg Arg Phe Glu Gln Phe Ala Pro Arg Tyr Asn Thr Glu Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Lys Tyr Lys Val Thr Ala Lys Leu Leu Pro Asn Ser 
            420                 425                 430         


Lys Gly Glu His Gly Lys Lys Leu His Gln Pro Leu Pro Glu Ala Phe 
        435                 440                 445             


Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu Leu Asp Tyr Leu Gln 
    450                 455                 460                 


Lys Gly Glu Ala Glu Lys Leu Ile Asn Asp Phe Ile Phe Val Asn Asn 
465                 470                 475                 480 


Cys Lys Leu Met Asn Met Pro Phe Ile Glu Ser Val Lys Asn Gln Leu 
                485                 490                 495     


Pro Lys Glu Trp Asp Glu Phe Gln Arg Arg Thr Asp Gly Lys Arg Glu 
            500                 505                 510         


Met Ala Tyr Asp Glu Asn Thr Leu Ala Tyr Leu Gln Leu Arg Lys Gln 
        515                 520                 525             


Ile Leu Asn Gln Val Leu Ala Glu Tyr Gln Leu Asn Asp Lys Gln Ile 
    530                 535                 540                 


Pro Gly Arg Ile Leu Asp Tyr Trp Leu Asn Ile Thr Leu Ala Asp Glu 
545                 550                 555                 560 


Gly Arg Ala Ile Ser Asn Arg Ile Lys Ser Ile Lys Arg Asp Cys Met 
                565                 570                 575     


Ser Arg Leu Lys Ala Leu Arg Lys Phe Lys Glu Asp Arg Asn Arg Ser 
            580                 585                 590         


Lys Ile Pro Ala Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp Ile 
        595                 600                 605             


Ile Asp Met Val Val Ser Glu Arg Lys Lys His Arg Ile Thr Ser Phe 
    610                 615                 620                 


Tyr Phe Asn Lys Ile Gln Glu Cys Leu Val Gln Phe Thr Val Pro Glu 
625                 630                 635                 640 


Lys Lys Gln Leu Phe Ile His Ile Val Thr Lys Glu Leu Arg Leu Asn 
                645                 650                 655     


Asp Thr Gly Gly His Pro Phe Leu Tyr Lys Leu Asp Leu Lys Gln Ile 
            660                 665                 670         


Asn Ser Thr Leu Asp Phe Tyr Glu Met Tyr Leu Gln Glu Lys Gly Tyr 
        675                 680                 685             


Lys Met Val Pro Glu Thr Asn Leu Lys Thr Gly Lys Val Val Tyr Thr 
    690                 695                 700                 


Asp His Ser Trp Thr Ala Leu Thr Phe Tyr Lys Ile Glu Phe Asn Asp 
705                 710                 715                 720 


Asn Val Asp Lys Leu Met Thr Val Val Lys Leu Pro Leu Asn Lys Leu 
                725                 730                 735     


Asn Leu Pro Phe Thr Ile Arg Gln Phe Ala Gly Lys Ser Thr Tyr Thr 
            740                 745                 750         


Leu Glu Gln Trp Leu Asn Asn Leu Thr Lys Gly Lys Asn Leu Asp Asn 
        755                 760                 765             


Gly Lys Gln Pro Val Asn Leu Pro Thr Asn Leu Phe Asp Asp Lys Leu 
    770                 775                 780                 


Thr Glu Leu Leu Arg Arg Asp Leu Glu Lys Lys Lys Ile Ile Tyr Trp 
785                 790                 795                 800 


Gln Tyr Ala Asn Trp Asn Glu Leu Phe Lys Ile Trp Trp Gly Ser Arg 
                805                 810                 815     


Asn Asp Ser Leu Gln Ser Phe Tyr Asn Ala Glu Arg Glu Tyr His Ile 
            820                 825                 830         


Phe Asp Glu Lys Val Asn Phe Tyr Pro Asn Arg Arg Glu Asn Phe Ala 
        835                 840                 845             


Asp Tyr Tyr Gln His Ala Leu Lys Ile Ala Phe Gln Lys Lys Arg Asn 
    850                 855                 860                 


Glu Arg Ile Leu Lys Gln Arg Glu Asp Lys His Leu Pro Asp Ile Ile 
865                 870                 875                 880 


Phe Glu Gln Ile Glu Lys Ile Phe Lys His Thr Ile Ala Glu Thr Glu 
                885                 890                 895     


Lys Glu Ile Arg Ile Leu Gln Glu Glu Asp Arg Ile Met Leu Leu Met 
            900                 905                 910         


Leu Glu Gly Leu Leu Glu Asp Ala Lys Asn Asp Gln Pro Leu Lys Leu 
        915                 920                 925             


Ser Glu Ile Lys Thr Leu Leu Asn Thr Thr Thr Asn Ile Arg Leu Ser 
    930                 935                 940                 


Val Ser Gly Lys Leu Ser Phe Asn Gln Phe Gly Glu Pro Ile Lys Gly 
945                 950                 955                 960 


Lys Val His Pro Glu Ile Val Arg Thr Val Ser Val Thr Ser Lys Pro 
                965                 970                 975     


Lys Glu Phe Asn Leu Leu Ser Lys Phe Ala Val Asp Lys Arg Leu Pro 
            980                 985                 990         


Glu Leu Phe Glu Tyr Phe Thr Asp  Glu Glu Ile Gln Phe  Glu Ser Leu 
        995                 1000                 1005             


Lys Thr  Glu Leu Asn Ala Tyr  His Lys Ala Lys Gln  Met Val Leu 
    1010                 1015                 1020             


Asp Leu  Ser Phe Lys Leu Glu  Arg Met Ile Ile Glu  Lys Gly Thr 
    1025                 1030                 1035             


Asn Asp  Arg Ile Lys Gln Leu  Cys Thr Cys Ala Ser  Gly Asp Leu 
    1040                 1045                 1050             


Leu Thr  Gly Asn Ile Cys His  Lys Thr Tyr Leu Thr  Trp Leu Lys 
    1055                 1060                 1065             


Asn Thr  Gly Thr Ile Asp Phe  Asp Thr Phe Ile Phe  Met Asn Met 
    1070                 1075                 1080             


Val His  Tyr Ser Phe Ser His  Asn Gln Phe Pro Gln  Lys Lys Thr 
    1085                 1090                 1095             


Met Glu  Arg Leu Ile Arg Arg  Trp Asp Ala Asn Arg  Phe Ala Leu 
    1100                 1105                 1110             


Gln Ile  Glu Ala Thr Tyr Ile  Gln Lys Ile Ala Gly  Ile Ile Glu 
    1115                 1120                 1125             


His Leu  
    1130 


<210>  1849
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1849

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1850
<211>  1164
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1850

Met Thr Ala Thr Asn Gly Leu Gly Lys Gly Ile Ser Tyr His His His 
1               5                   10                  15      


Leu Tyr Ala Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Asp 
            20                  25                  30          


Asp Asn Ile Asp Gln Val Lys Gln Leu Phe Asp Thr Arg Phe Gly Glu 
        35                  40                  45              


Lys Asn Ala Asp Arg Phe Phe Ser Thr Lys Asn Asn His Leu Ile Ala 
    50                  55                  60                  


Tyr Asp Asp Trp Glu Lys Gly Ile Asp Phe Leu Lys Gln Tyr Leu Pro 
65                  70                  75                  80  


Val Val His Tyr Leu Ala Leu Pro Val Asn His Glu Lys Phe Ser Asn 
                85                  90                  95      


Leu Thr Asp Lys Glu Lys Gly Arg Arg Asp Tyr Phe Thr Ile His Phe 
            100                 105                 110         


Asn Leu Leu Thr Ser Thr Ile His Asp Cys Arg Asn Phe Tyr Thr His 
        115                 120                 125             


Tyr Tyr His Asp Pro Ile Thr Val Gln Asn Asp Leu Phe Gln Leu Leu 
    130                 135                 140                 


Asp Glu Leu Phe Ile Leu Val Cys Arg Asp Val Arg Lys His Arg Ile 
145                 150                 155                 160 


Lys Thr Asp Lys Thr Gly Trp Leu Leu Lys Arg Thr Leu Gln Asn Glu 
                165                 170                 175     


Leu Gln Ile Leu Thr Lys His Lys Lys His Thr Leu Glu Lys Gln Lys 
            180                 185                 190         


Lys Glu Gly Lys Lys Val Asn Leu Asp Ala Glu Ala Ile Glu Asn Ala 
        195                 200                 205             


Val Met Asn Asp Ala Phe Lys His Leu Arg Tyr Thr Asp Lys Glu Asp 
    210                 215                 220                 


Asn Lys Gly Asn Ile Lys Lys Phe Leu Val Lys Asp Gln Tyr Lys Ser 
225                 230                 235                 240 


Ala Tyr Asn Arg Gln Glu Pro Ser Glu Asn Gly Ile Cys Leu Ser Arg 
                245                 250                 255     


Ser Gly Leu Leu Phe Leu Cys Ser Met Phe Leu Ser Arg Lys Ala Gly 
            260                 265                 270         


Glu Asp Met Arg Ala Arg Val Ser Gly Phe Lys Glu Lys Phe Val Tyr 
        275                 280                 285             


Arg Thr Glu Glu Glu Ile Thr Asp Lys Asn Asn Ser Leu Arg Ser Met 
    290                 295                 300                 


Val Thr Gln Trp Val Phe Ser His Leu Ala Phe Lys Asp Ile Lys Gln 
305                 310                 315                 320 


Arg Ile Thr Thr Asn Leu Asp Arg Glu Thr Leu Phe Val Gln Ile Val 
                325                 330                 335     


Asp Tyr Leu Ser Lys Val Pro Asp Glu Leu Tyr Gln Val Phe Ser Asn 
            340                 345                 350         


Thr Gln Lys Leu Asp Phe Leu Glu Asp Ile Asn Glu Tyr Ile Lys Glu 
        355                 360                 365             


Gly Asn Lys Thr Glu Ser Leu Ile Gln Ser Thr Val Ala His Pro Val 
    370                 375                 380                 


Ile Arg Lys Arg Tyr Glu Asn Gln Phe Asn Tyr Phe Val Leu Arg Tyr 
385                 390                 395                 400 


Leu Asp Glu Phe Val Glu Phe Pro Ser Leu Arg Phe Gln Ile Asn Thr 
                405                 410                 415     


Gly Phe Tyr Thr His Asp Gln Arg Glu Lys Thr Ile Glu Gly Thr Glu 
            420                 425                 430         


Tyr Leu Thr Asp Arg Lys Ile Lys Glu Lys Ile Lys Val Phe Gly Lys 
        435                 440                 445             


Leu Ser Glu Val Thr Thr Gln Lys Asn Glu Phe Leu Val Lys Asn Thr 
    450                 455                 460                 


Asp Leu Gln Gly Trp Glu Ala Tyr Pro Gly Pro Ser Tyr Asn Val Asn 
465                 470                 475                 480 


Asn Asn Asn Ile Pro Val Phe Ile Asn Met Gln Asn Asn Ala Val Asn 
                485                 490                 495     


Gly Ser Lys Gln Trp Tyr Ser Lys Ile Asn Phe Lys Ile Arg Asn Glu 
            500                 505                 510         


Arg Asn Leu Lys Gln Ser Pro Arg Thr Glu Asp Lys Lys Gln Lys Ser 
        515                 520                 525             


Ala Ile Ala Asp Met Leu Lys Ile Asn Gly Glu Met Asp Leu Arg Tyr 
    530                 535                 540                 


Glu Glu Pro Thr Ala Ile Leu Cys Leu Lys Glu Leu Pro Ser Leu Leu 
545                 550                 555                 560 


Tyr Glu Leu Leu Tyr Thr Lys Ala Ser Pro Lys Glu Ile Glu Glu His 
                565                 570                 575     


Leu Leu Lys Lys Ile Ile Gly His Leu Asp Thr Ile Glu Lys Tyr Ala 
            580                 585                 590         


His His Thr Asp Ser Ser Leu Gln Gly Met Pro Arg Lys Leu Lys Lys 
        595                 600                 605             


Ser Gly Glu Glu Ser Ser Ile Asn Tyr Lys Lys Leu Arg Glu Val Ile 
    610                 615                 620                 


Val Asn Glu Leu Lys Val Ile Thr Glu Lys Gln Asp Phe Leu Lys Glu 
625                 630                 635                 640 


Lys Gln Lys Asp Lys Lys Val Asn Lys Arg Leu Tyr Leu Leu Asn Asn 
                645                 650                 655     


Arg Glu Met Gly Lys Glu Ala Thr Trp Leu Ala Ser Asp Leu Ile Arg 
            660                 665                 670         


Phe Met Pro Glu Thr Ala Arg Lys Gln Trp Lys Gly Tyr His His Ser 
        675                 680                 685             


Gln Leu Gln Gln Thr Leu Ala Phe Tyr Gln Gln Lys Arg Lys Glu Ala 
    690                 695                 700                 


Leu Ser Leu Ile Gly Gln Phe Trp Asp Phe Asn Thr Gly Pro Tyr Trp 
705                 710                 715                 720 


Gly Asp Lys Leu Lys Lys Ala Phe Glu Gln Thr Thr Phe Glu Asp Phe 
                725                 730                 735     


Tyr Phe Glu Tyr Leu Lys Met Arg Gln Ala Ile Leu Asn Asn Phe Leu 
            740                 745                 750         


Glu Asn Val Ser Ser Ser Gln Asn Gln Pro Asn Leu Ala Lys Lys Ala 
        755                 760                 765             


Leu Lys Asp Cys Trp Ile Ile Phe His Lys Arg His Phe Ile Ile Arg 
    770                 775                 780                 


Pro Ala Lys Glu Gln Ile Ser Ser Leu Leu Ala Gln Pro Val Val Leu 
785                 790                 795                 800 


Pro Arg Gly Leu Phe Asp Asn Lys Pro Thr Tyr Ile Lys Asp Val Lys 
                805                 810                 815     


Leu Glu Asp Ala Pro Glu Lys Phe Ala Asn Trp Tyr Arg Tyr Thr Tyr 
            820                 825                 830         


Asn Asp Tyr Pro Met Gln Arg Phe Tyr Ser Phe Asp Arg Asp Tyr Thr 
        835                 840                 845             


Ser Leu Tyr Glu Glu Phe Gln Ser Asn Lys Asp Val Ile Leu Asn Lys 
    850                 855                 860                 


Lys Arg Leu Thr Lys Ser Glu Gln Glu Ala Leu Leu Lys Lys Lys Gln 
865                 870                 875                 880 


Asp Leu Lys Ile Lys Asp Ile Arg Thr Gln Asp Leu Phe Leu Lys Leu 
                885                 890                 895     


Ile Ala Asp Lys Leu Phe Glu Asp Ile Phe Asp Gln Lys Ala Asp Phe 
            900                 905                 910         


Thr Leu Glu Asp Ile Tyr Gln Thr Arg Glu Glu Arg Met Gln Asn Gly 
        915                 920                 925             


Glu Gln Ala Leu Gln Gln Ser Glu Arg Ala Pro Gly Asp Asp Phe Glu 
    930                 935                 940                 


Asn Ile Tyr Asn Glu Ser Phe Val Leu Asn Lys Thr Val Pro Phe Ile 
945                 950                 955                 960 


Gln Lys Gln Ile His Glu Pro Thr Val Lys Ile Lys Asp Leu Gly Lys 
                965                 970                 975     


Phe Lys Arg Phe Leu Phe Asp Asn Lys Val Lys Ala Leu Phe Ser Tyr 
            980                 985                 990         


Glu Pro Asn Arg Val Trp Ser Ile  Gln Glu Leu Glu Asn  Glu Leu Thr 
        995                 1000                 1005             


Leu Leu  Pro Thr Ser Tyr Glu  Val Ile Arg Arg Val  Ser Leu Leu 
    1010                 1015                 1020             


Lys Ala  Ile Gln Glu Phe Glu  Lys Tyr Ile Met Glu  Cys Trp Gly 
    1025                 1030                 1035             


Asp Ser  Asp Thr Thr Lys Leu  Asp Gln Lys Asp Lys  Lys Ser Gly 
    1040                 1045                 1050             


Lys Tyr  Asn Pro Ser Phe Lys  Lys Tyr Ile Phe Asn  Gly Val Leu 
    1055                 1060                 1065             


Asp Lys  Phe Arg Leu Ala Asn  Ala Glu Asn Ile Lys  His Ile Ile 
    1070                 1075                 1080             


Asp Tyr  Lys Lys Phe Glu Glu  Leu Val Asp Asp Pro  Gln Leu Lys 
    1085                 1090                 1095             


Ser Phe  Glu Glu Ile Val Arg  Lys Ala Tyr Ile Leu  Thr Ile Ile 
    1100                 1105                 1110             


Arg Asn  Lys Ile Ala His Asn  Gln Leu Pro Asp Lys  Ala Asn Met 
    1115                 1120                 1125             


Asp Phe  Ile Gln Gly Met Tyr  Pro Lys Glu Pro Gln  Asp Ser Tyr 
    1130                 1135                 1140             


Ser Gln  Tyr Leu Leu Arg Val  Thr Gln Leu Ile Ile  Asp Glu Met 
    1145                 1150                 1155             


Val Leu  Leu Met Lys Ile 
    1160                 


<210>  1851
<211>  1164
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1851

Met Thr Ala Thr Asn Gly Leu Gly Lys Gly Ile Ser Tyr His His His 
1               5                   10                  15      


Leu Tyr Ala Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Asp 
            20                  25                  30          


Asp Asn Ile Asp Gln Val Lys Gln Leu Phe Asp Thr Arg Phe Gly Glu 
        35                  40                  45              


Lys Asn Ala Asp Arg Phe Phe Ser Thr Lys Asn Asn His Leu Ile Ala 
    50                  55                  60                  


Tyr Asp Asp Trp Glu Lys Gly Ile Asp Phe Leu Lys Gln Tyr Leu Pro 
65                  70                  75                  80  


Val Val His Tyr Leu Ala Leu Pro Val Asn His Glu Lys Phe Ser Asn 
                85                  90                  95      


Leu Thr Asp Lys Glu Lys Gly Arg Arg Asp Tyr Phe Thr Ile His Phe 
            100                 105                 110         


Asn Leu Leu Thr Ser Thr Ile His Asp Cys Arg Asn Phe Tyr Thr His 
        115                 120                 125             


Tyr Tyr His Asp Pro Ile Thr Val Gln Asn Asp Leu Phe Gln Leu Leu 
    130                 135                 140                 


Asp Glu Leu Phe Ile Leu Val Cys Arg Asp Val Arg Lys His Arg Ile 
145                 150                 155                 160 


Lys Thr Asp Lys Thr Gly Trp Leu Leu Lys Arg Thr Leu Gln Asn Glu 
                165                 170                 175     


Leu Gln Ile Leu Thr Lys His Lys Lys His Thr Leu Glu Lys Gln Lys 
            180                 185                 190         


Lys Glu Gly Lys Lys Val Asn Leu Asp Ala Glu Ala Ile Glu Asn Ala 
        195                 200                 205             


Val Met Asn Asp Ala Phe Lys His Leu Arg Tyr Thr Asp Lys Glu Asp 
    210                 215                 220                 


Asn Lys Gly Asn Ile Lys Lys Phe Leu Val Lys Asp Gln Tyr Lys Ser 
225                 230                 235                 240 


Ala Tyr Asn Arg Gln Glu Pro Ser Glu Asn Gly Ile Cys Leu Ser Arg 
                245                 250                 255     


Ser Gly Leu Leu Phe Leu Cys Ser Met Phe Leu Ser Arg Lys Ala Gly 
            260                 265                 270         


Glu Asp Met Arg Ala Arg Val Ser Gly Phe Lys Glu Lys Phe Val Tyr 
        275                 280                 285             


Arg Thr Glu Glu Glu Ile Thr Asp Lys Asn Asn Ser Leu Arg Ser Met 
    290                 295                 300                 


Val Thr Gln Trp Val Phe Ser His Leu Ala Phe Lys Asp Ile Lys Gln 
305                 310                 315                 320 


Arg Ile Thr Thr Asn Leu Asp Arg Glu Thr Leu Phe Val Gln Ile Val 
                325                 330                 335     


Asp Tyr Leu Ser Lys Val Pro Asp Glu Leu Tyr Gln Val Phe Ser Asn 
            340                 345                 350         


Thr Gln Lys Leu Asp Phe Leu Glu Asp Ile Asn Glu Tyr Ile Lys Glu 
        355                 360                 365             


Gly Asn Lys Thr Glu Ser Leu Ile Gln Ser Thr Val Ala His Pro Val 
    370                 375                 380                 


Ile Arg Lys Arg Tyr Glu Asn Gln Phe Asn Tyr Phe Val Leu Arg Tyr 
385                 390                 395                 400 


Leu Asp Glu Phe Val Glu Phe Pro Ser Leu Arg Phe Gln Ile Asn Thr 
                405                 410                 415     


Gly Phe Tyr Thr His Asp Gln Arg Glu Lys Thr Ile Glu Gly Thr Glu 
            420                 425                 430         


Tyr Leu Thr Asp Arg Lys Ile Lys Glu Lys Ile Lys Val Phe Gly Lys 
        435                 440                 445             


Leu Ser Glu Val Thr Thr Gln Lys Asn Glu Phe Leu Val Lys Asn Thr 
    450                 455                 460                 


Asp Leu Gln Gly Trp Glu Ala Tyr Pro Gly Pro Ser Tyr Asn Val Asn 
465                 470                 475                 480 


Asn Asn Asn Ile Pro Val Phe Ile Asn Met Gln Asn Asn Ala Val Asn 
                485                 490                 495     


Gly Ser Lys Gln Trp Tyr Ser Lys Ile Asn Phe Lys Ile Arg Asn Glu 
            500                 505                 510         


Arg Asn Leu Lys Gln Ser Pro Arg Thr Glu Asp Lys Lys Gln Lys Ser 
        515                 520                 525             


Ala Ile Ala Asp Met Leu Lys Ile Asn Gly Glu Met Asp Leu Arg Tyr 
    530                 535                 540                 


Glu Glu Pro Thr Ala Ile Leu Cys Leu Lys Glu Leu Pro Ser Leu Leu 
545                 550                 555                 560 


Tyr Glu Leu Leu Tyr Thr Lys Ala Ser Pro Lys Glu Ile Glu Glu His 
                565                 570                 575     


Leu Leu Lys Lys Ile Ile Gly His Leu Asp Thr Ile Glu Lys Tyr Ala 
            580                 585                 590         


His His Thr Asp Ser Ser Leu Gln Gly Met Pro Arg Lys Leu Lys Lys 
        595                 600                 605             


Ser Gly Glu Glu Ser Ser Ile Asn Tyr Lys Lys Leu Arg Glu Val Ile 
    610                 615                 620                 


Val Asn Glu Leu Lys Val Ile Thr Glu Lys Gln Asp Phe Leu Lys Glu 
625                 630                 635                 640 


Lys Gln Lys Asp Lys Lys Val Asn Lys Arg Leu Tyr Leu Leu Asn Asn 
                645                 650                 655     


Arg Glu Met Gly Lys Glu Ala Thr Trp Leu Ala Ser Asp Leu Ile Arg 
            660                 665                 670         


Phe Met Pro Glu Thr Ala Arg Lys Gln Trp Lys Gly Tyr His His Ser 
        675                 680                 685             


Gln Leu Gln Gln Thr Leu Ala Phe Tyr Gln Gln Lys Arg Lys Glu Ala 
    690                 695                 700                 


Leu Ser Leu Ile Gly Gln Phe Trp Asp Phe Asn Thr Gly Pro Tyr Trp 
705                 710                 715                 720 


Gly Asp Lys Leu Lys Lys Ala Phe Glu Gln Thr Thr Phe Glu Asp Phe 
                725                 730                 735     


Tyr Phe Glu Tyr Leu Lys Met Arg Gln Ala Ile Leu Asn Asn Phe Leu 
            740                 745                 750         


Glu Asn Val Ser Ser Ser Gln Asn Gln Pro Asn Leu Ala Lys Lys Ala 
        755                 760                 765             


Leu Lys Asp Cys Trp Ile Ile Phe His Lys Arg His Phe Ile Ile Arg 
    770                 775                 780                 


Pro Ala Lys Glu Gln Ile Ser Ser Leu Leu Ala Gln Pro Val Val Leu 
785                 790                 795                 800 


Pro Arg Gly Leu Phe Asp Asn Lys Pro Thr Tyr Ile Lys Asp Val Lys 
                805                 810                 815     


Leu Glu Asp Ala Pro Glu Lys Phe Ala Asn Trp Tyr Arg Tyr Thr Tyr 
            820                 825                 830         


Asn Asp Tyr Pro Met Gln Arg Phe Tyr Ser Phe Asp Arg Asp Tyr Thr 
        835                 840                 845             


Ser Leu Tyr Glu Glu Phe Gln Ser Asn Lys Asp Val Ile Leu Asn Lys 
    850                 855                 860                 


Lys Arg Leu Thr Lys Ser Glu Gln Glu Ala Leu Leu Lys Lys Lys Gln 
865                 870                 875                 880 


Asp Leu Lys Ile Lys Asp Ile Arg Thr Gln Asp Leu Phe Leu Lys Leu 
                885                 890                 895     


Ile Ala Asp Lys Leu Phe Glu Asp Ile Phe Asp Gln Lys Ala Asp Phe 
            900                 905                 910         


Thr Leu Glu Asp Ile Tyr Gln Thr Arg Glu Glu Arg Met Gln Asn Gly 
        915                 920                 925             


Glu Gln Ala Leu Gln Gln Ser Glu Arg Ala Pro Gly Asp Asp Phe Glu 
    930                 935                 940                 


Asn Ile Tyr Asn Glu Ser Phe Val Leu Asn Lys Thr Val Pro Phe Ile 
945                 950                 955                 960 


Gln Lys Gln Ile His Glu Pro Thr Val Lys Ile Lys Asp Leu Gly Lys 
                965                 970                 975     


Phe Lys Arg Phe Leu Phe Asp Asn Lys Val Lys Ala Leu Phe Ser Tyr 
            980                 985                 990         


Glu Pro Asn Arg Val Trp Ser Ile  Gln Glu Leu Glu Asn  Glu Leu Thr 
        995                 1000                 1005             


Leu Leu  Pro Thr Ser Tyr Glu  Val Ile Arg Arg Val  Ser Leu Leu 
    1010                 1015                 1020             


Lys Ala  Ile Gln Glu Phe Glu  Lys Tyr Ile Met Glu  Cys Trp Gly 
    1025                 1030                 1035             


Asp Ser  Asp Thr Thr Lys Leu  Asp Gln Lys Asp Lys  Lys Ser Gly 
    1040                 1045                 1050             


Lys Tyr  Asn Pro Ser Phe Lys  Lys Tyr Ile Phe Asn  Gly Val Leu 
    1055                 1060                 1065             


Asp Lys  Phe Arg Leu Ala Asn  Ala Glu Asn Ile Lys  His Ile Ile 
    1070                 1075                 1080             


Asp Tyr  Lys Lys Phe Glu Glu  Leu Val Asp Asp Pro  Gln Leu Lys 
    1085                 1090                 1095             


Ser Phe  Glu Glu Ile Val Arg  Lys Ala Tyr Ile Leu  Thr Ile Ile 
    1100                 1105                 1110             


Arg Asn  Lys Ile Ala His Asn  Gln Leu Pro Asp Lys  Ala Asn Met 
    1115                 1120                 1125             


Asp Phe  Ile Gln Gly Met Tyr  Pro Lys Glu Pro Gln  Asp Ser Tyr 
    1130                 1135                 1140             


Ser Gln  Tyr Leu Leu Arg Val  Thr Gln Leu Ile Ile  Asp Glu Met 
    1145                 1150                 1155             


Val Leu  Leu Met Lys Ile 
    1160                 


<210>  1852
<211>  1090
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1852

Met Glu Lys Val Thr Asn Thr Asp Lys Asn Ile Lys Pro Asn Tyr Arg 
1               5                   10                  15      


Ser Phe Lys Glu Glu Glu Ser Lys Pro Phe Tyr Ala Ala Tyr Leu Asn 
            20                  25                  30          


Thr Ala Ile His Asn Ile Tyr Thr Val Phe Lys Asp Ile Ser Glu Ser 
        35                  40                  45              


Leu Gly Ile Ala Phe Asn Phe Lys Asn Asp Tyr Gln Ile Leu Gly Ser 
    50                  55                  60                  


Asp Leu Ile Lys Lys Leu Glu Glu Asn Asn Glu Pro Glu Leu Ser Gln 
65                  70                  75                  80  


Lys Ile Ile Glu Arg Leu Asp Arg Gln Phe Ser Phe Leu Lys Thr Leu 
                85                  90                  95      


Thr Leu His Asn Ala Lys Asn Arg Thr Gln Ala Asp Ala Pro Leu Ala 
            100                 105                 110         


Asp Ala Ile Asp Tyr His Gln Val Ile Lys Leu Trp Val Ser Gln Leu 
        115                 120                 125             


Met Asp Tyr Arg Asn Phe Tyr Ser His Ala Leu His Val Pro Ile Gln 
    130                 135                 140                 


Met Asp Pro Phe Ile Val Asp Gly Met Arg Ser Leu Tyr Asp Ala Asp 
145                 150                 155                 160 


Trp Lys Glu Phe Lys Glu Arg Lys Thr Leu Ser Thr Glu Asp Thr Ala 
                165                 170                 175     


His Leu Ile Arg Leu Gly Lys Asn Gly Glu Ser Arg Asn Phe His Tyr 
            180                 185                 190         


Ala Phe Leu Asp Lys Gln Gly Asn Ile Thr Glu Lys Gly Phe Leu Tyr 
        195                 200                 205             


Phe Thr Cys Leu Trp Leu Glu Lys Lys Asp Ala Gln Glu Leu Leu Lys 
    210                 215                 220                 


Lys His Lys Gly Phe Lys Arg Gly Glu Ser Lys Ser Gln Lys Ala Thr 
225                 230                 235                 240 


Leu Glu Lys Phe Ile Trp Phe Gly Thr Arg Val Pro Lys Pro Arg Leu 
                245                 250                 255     


Thr Ser Asp Asn Ser Gln Gln Gly Leu Phe Met Asp Met Val Asn Asp 
            260                 265                 270         


Leu Lys Arg Cys Pro Val Val Leu Phe Asp Leu Leu Ser Glu Ala Asp 
        275                 280                 285             


Lys Ala Arg Phe Tyr Thr Glu Asp Glu Phe Gly Ala Asp Glu Glu Asp 
    290                 295                 300                 


Gly Tyr Glu Ala Lys Pro Phe Leu Ile Arg Lys Thr Asn Arg Phe Tyr 
305                 310                 315                 320 


Tyr Phe Ala Met Arg Phe Leu Glu Gln Arg Phe Glu His Leu Lys Phe 
                325                 330                 335     


His Ile Asp Leu Gly Asn Tyr Cys Tyr Lys Thr Tyr Asp Gln Val Ile 
            340                 345                 350         


Glu Gly Val Thr Arg Lys Arg Arg Trp Ile Ser Arg Ile Thr Ala Phe 
        355                 360                 365             


Gly Asn Leu Thr Asp Phe Arg Glu Ser Asp Pro Pro Leu Ala Trp Arg 
    370                 375                 380                 


Glu Lys Leu Leu Ser Pro Gly Glu Thr Asp Lys Pro Ser Thr Tyr Ile 
385                 390                 395                 400 


Thr Pro Thr Thr Ala His Tyr His Phe Asp Pro Ser Ser Lys Val Met 
                405                 410                 415     


Ala Ile Gly Leu Lys Trp Val Glu Asp Tyr Arg Lys Asp Ala Ile Trp 
            420                 425                 430         


Pro Asp Ile Glu Thr Ala Asp Val Asp Gln Lys Tyr Arg Asn Val Val 
        435                 440                 445             


Pro Asp Phe Trp Leu Ser Leu Tyr Glu Leu Pro Ser Leu Val Phe Tyr 
    450                 455                 460                 


Gln Ile Leu His Glu Lys Gly Leu Ile Glu His Ser Ala Glu Ser Ile 
465                 470                 475                 480 


Ile Lys Ser Tyr Arg Glu Lys Leu Asn Lys Gly Phe Leu Asn Asn Val 
                485                 490                 495     


Ala Glu Lys Arg Ile Leu Pro Gly Leu Ser Lys Val Glu Leu Glu Lys 
            500                 505                 510         


Glu Leu Lys Gln Arg Gly Leu Asp Ile Gln Cys Ile Pro Lys Thr Val 
        515                 520                 525             


Val Asn Tyr Leu Leu Ser Lys Asp Pro Glu Pro Ile Glu Ser Lys Ala 
    530                 535                 540                 


Lys Ala Arg Leu Ala Arg Leu Lys Glu Glu Asn Thr Cys Leu Leu Ser 
545                 550                 555                 560 


Gln Val Glu Arg Gln Glu Pro His Tyr Arg Met Lys Pro Gly Ser Lys 
                565                 570                 575     


Asn His Ile Ala Pro Lys Ala Gly Thr Ile Ala Asp Phe Leu Ala His 
            580                 585                 590         


Asp Met Leu Leu Leu Gln Lys Pro Ile Lys Gln Asp Gln Gly Lys Ala 
        595                 600                 605             


Asn Ser Thr Glu Phe Gln Ile Leu Gln Ala Lys Leu Ala Tyr Phe Asn 
    610                 615                 620                 


Gln Asn Lys Glu Ser Leu Asn Glu Thr Phe Lys Leu Cys Asn Leu Thr 
625                 630                 635                 640 


Glu Ala Pro Asn Ala His Pro Phe Leu Gly Arg Ile Glu Leu Ala Lys 
                645                 650                 655     


Cys Lys Gly Ile Val Asp Phe Tyr Lys Lys Tyr Leu Leu Gln Arg Ala 
            660                 665                 670         


Lys Phe Leu Asp Gln Cys Ile Met Asp Lys Ser Phe Lys Glu Tyr His 
        675                 680                 685             


Phe Leu Lys Ile Lys Asp Thr Ser Asp Thr Ile Lys Ala Leu Ile Glu 
    690                 695                 700                 


Lys Gln Gln Asn Ala Val Leu Asn Leu Pro Arg Gly Leu Phe Lys Ser 
705                 710                 715                 720 


His Ile Gln Thr Ala Leu Thr Lys Gly Asp Thr Thr Ser Lys Leu Leu 
                725                 730                 735     


Lys Asp Val Leu Ala Asp Asn Thr His Asn Asn Ala Phe Ile Ile Gln 
            740                 745                 750         


Glu Tyr Phe Lys Arg Val Glu Lys Asp Glu Ser Gln Thr Phe Tyr Glu 
        755                 760                 765             


Phe Lys Arg Ser Tyr Glu Leu Leu Thr Lys Leu Tyr Asp Thr Arg Arg 
    770                 775                 780                 


Pro Lys Asp Arg Lys Pro Ala Pro Pro Lys Phe Phe Ala Pro Glu Glu 
785                 790                 795                 800 


Leu Thr Glu Lys Tyr Arg Asp Ile Lys Lys Lys Leu Ala Leu Lys Ile 
                805                 810                 815     


Asp Gln Lys Leu Ala Gly Val Glu Lys Gly Ser Pro Glu Glu Ala Arg 
            820                 825                 830         


Ile Arg Ser Asn Phe Ser Lys Gln Tyr Lys Lys Leu Met Asp Asp Glu 
        835                 840                 845             


Lys Gln Ile Arg Leu Phe Lys Thr Cys Asp Met Val Gln Phe Leu Met 
    850                 855                 860                 


Val Asp Gln Leu Tyr Gln Gln Leu Gly Leu Glu Tyr Lys Ser Leu Val 
865                 870                 875                 880 


Lys Lys Asp Gln Thr Gly Thr Ser Phe Gln Met Gly Lys Glu Tyr Ser 
                885                 890                 895     


Leu Arg Glu Ile Ile Pro Asp Gly Gln Asp Gly Ile Leu Ser Leu Lys 
            900                 905                 910         


Thr Gln Val Lys Leu Pro Leu Tyr Leu Asp Lys Gly Asp Ser Thr Glu 
        915                 920                 925             


Cys Lys Ile Ile Val Arg Asp Lys Met Lys Ile Lys Asn Tyr Gly Asp 
    930                 935                 940                 


Phe Arg Leu Phe Leu Lys Asp Arg Arg Ile Lys Gly Leu Leu Pro Tyr 
945                 950                 955                 960 


Ile Asp Ala Glu Glu Ile Ala Tyr Glu Ala Leu Lys Arg Glu Leu Glu 
                965                 970                 975     


Glu Phe Asp Lys Cys Arg Arg Ala Val Ile Ala Glu Ile Leu Arg Phe 
            980                 985                 990         


Glu Gln Asn Thr Val Lys Lys Phe  Asn Met Glu Leu Ser  Gly Lys Arg 
        995                 1000                 1005             


Phe Phe  Asn His Glu Lys Phe  Leu Glu Lys Gly Ser  Gly Tyr Ser 
    1010                 1015                 1020             


Ala Glu  Glu Ile Glu Ser Met  Ser Leu Leu Arg Asn  Ala Phe Phe 
    1025                 1030                 1035             


His Ser  Ile Tyr Pro Ser Tyr  Glu Gln Phe Arg Gly  Lys Val Asn 
    1040                 1045                 1050             


Gly Glu  Arg Phe Asn Glu Leu  Lys Asp Tyr Thr Ala  Asp Asp Pro 
    1055                 1060                 1065             


Glu Val  Asp Gln Lys Ser Ile  Ile Gln Gln Leu Lys  Asn Leu Thr 
    1070                 1075                 1080             


Leu Ile  Tyr Tyr Arg Gly Leu  
    1085                 1090 


<210>  1853
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1853

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1854
<211>  1164
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1854

Met Thr Ala Thr Asn Gly Leu Gly Lys Gly Ile Ser Tyr His His His 
1               5                   10                  15      


Leu Tyr Ala Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Asp 
            20                  25                  30          


Asp Asn Ile Asp Gln Val Lys Gln Leu Phe Asp Thr Arg Phe Gly Glu 
        35                  40                  45              


Lys Asn Ala Asp Arg Phe Phe Ser Thr Lys Asn Asn His Leu Ile Ala 
    50                  55                  60                  


Tyr Asp Asp Trp Glu Lys Gly Ile Asp Phe Leu Lys Gln Tyr Leu Pro 
65                  70                  75                  80  


Val Val His Tyr Leu Ala Leu Pro Val Asn His Glu Lys Phe Ser Asn 
                85                  90                  95      


Leu Thr Asp Lys Glu Lys Gly Arg Arg Asp Tyr Phe Thr Ile His Phe 
            100                 105                 110         


Asn Leu Leu Thr Ser Thr Ile His Asp Cys Arg Asn Phe Tyr Thr His 
        115                 120                 125             


Tyr Tyr His Asp Pro Ile Thr Val Gln Asn Asp Leu Phe Gln Leu Leu 
    130                 135                 140                 


Asp Glu Leu Phe Ile Leu Val Cys Arg Asp Val Arg Lys His Arg Ile 
145                 150                 155                 160 


Lys Thr Asp Lys Thr Gly Trp Leu Leu Lys Arg Thr Leu Gln Asn Glu 
                165                 170                 175     


Leu Gln Ile Leu Thr Lys His Lys Lys His Thr Leu Glu Lys Gln Lys 
            180                 185                 190         


Lys Glu Gly Lys Lys Val Asn Leu Asp Ala Glu Ala Ile Glu Asn Ala 
        195                 200                 205             


Val Met Asn Asp Ala Phe Lys His Leu Arg Tyr Thr Asp Lys Glu Asp 
    210                 215                 220                 


Asn Lys Gly Asn Ile Lys Lys Phe Leu Val Lys Asp Gln Tyr Lys Ser 
225                 230                 235                 240 


Ala Tyr Asn Arg Gln Glu Pro Ser Glu Asn Gly Ile Cys Leu Ser Arg 
                245                 250                 255     


Ser Gly Leu Leu Phe Leu Cys Ser Met Phe Leu Ser Arg Lys Ala Gly 
            260                 265                 270         


Glu Asp Met Arg Ala Arg Val Ser Gly Phe Lys Glu Lys Phe Val Tyr 
        275                 280                 285             


Arg Thr Glu Glu Glu Ile Thr Asp Lys Asn Asn Ser Leu Arg Ser Met 
    290                 295                 300                 


Val Thr Gln Trp Val Phe Ser His Leu Ala Phe Lys Asp Ile Lys Gln 
305                 310                 315                 320 


Arg Ile Thr Thr Asn Leu Asp Arg Glu Thr Leu Phe Val Gln Ile Val 
                325                 330                 335     


Asp Tyr Leu Ser Lys Val Pro Asp Glu Leu Tyr Gln Val Phe Ser Asn 
            340                 345                 350         


Thr Gln Lys Leu Asp Phe Leu Glu Asp Ile Asn Glu Tyr Ile Lys Glu 
        355                 360                 365             


Gly Asn Lys Thr Glu Ser Leu Ile Gln Ser Thr Val Ala His Pro Val 
    370                 375                 380                 


Ile Arg Lys Arg Tyr Glu Asn Gln Phe Asn Tyr Phe Val Leu Arg Tyr 
385                 390                 395                 400 


Leu Asp Glu Phe Val Glu Phe Pro Ser Leu Arg Phe Gln Ile Asn Thr 
                405                 410                 415     


Gly Phe Tyr Thr His Asp Gln Arg Glu Lys Thr Ile Glu Gly Thr Glu 
            420                 425                 430         


Tyr Leu Thr Asp Arg Lys Ile Lys Glu Lys Ile Lys Val Phe Gly Lys 
        435                 440                 445             


Leu Ser Glu Val Thr Thr Gln Lys Asn Glu Phe Leu Val Lys Asn Thr 
    450                 455                 460                 


Asp Leu Gln Gly Trp Glu Ala Tyr Pro Gly Pro Ser Tyr Asn Val Asn 
465                 470                 475                 480 


Asn Asn Asn Ile Pro Val Phe Ile Asn Met Gln Asn Asn Ala Val Asn 
                485                 490                 495     


Gly Ser Lys Gln Trp Tyr Ser Lys Ile Asn Phe Lys Ile Arg Asn Glu 
            500                 505                 510         


Arg Asn Leu Lys Gln Ser Pro Arg Thr Glu Asp Lys Lys Gln Lys Ser 
        515                 520                 525             


Ala Ile Ala Asp Met Leu Lys Ile Asn Gly Glu Met Asp Leu Arg Tyr 
    530                 535                 540                 


Glu Glu Pro Thr Ala Ile Leu Cys Leu Lys Glu Leu Pro Ser Leu Leu 
545                 550                 555                 560 


Tyr Glu Leu Leu Tyr Thr Lys Ala Ser Pro Lys Glu Ile Glu Glu His 
                565                 570                 575     


Leu Leu Lys Lys Ile Ile Gly His Leu Asp Thr Ile Glu Lys Tyr Ala 
            580                 585                 590         


His His Thr Asp Ser Ser Leu Gln Gly Met Pro Arg Lys Leu Lys Lys 
        595                 600                 605             


Ser Gly Glu Glu Ser Ser Ile Asn Tyr Lys Lys Leu Arg Glu Val Ile 
    610                 615                 620                 


Val Asn Glu Leu Lys Val Ile Thr Glu Lys Gln Asp Phe Leu Lys Glu 
625                 630                 635                 640 


Lys Gln Lys Asp Lys Lys Val Asn Lys Arg Leu Tyr Leu Leu Asn Asn 
                645                 650                 655     


Arg Glu Met Gly Lys Glu Ala Thr Trp Leu Ala Ser Asp Leu Ile Arg 
            660                 665                 670         


Phe Met Pro Glu Thr Ala Arg Lys Gln Trp Lys Gly Tyr His His Ser 
        675                 680                 685             


Gln Leu Gln Gln Thr Leu Ala Phe Tyr Gln Gln Lys Arg Lys Glu Ala 
    690                 695                 700                 


Leu Ser Leu Ile Gly Gln Phe Trp Asp Phe Asn Thr Gly Pro Tyr Trp 
705                 710                 715                 720 


Gly Asp Lys Leu Lys Lys Ala Phe Glu Gln Thr Thr Phe Glu Asp Phe 
                725                 730                 735     


Tyr Phe Glu Tyr Leu Lys Met Arg Gln Ala Ile Leu Asn Asn Phe Leu 
            740                 745                 750         


Glu Asn Val Ser Ser Ser Gln Asn Gln Pro Asn Leu Ala Lys Lys Ala 
        755                 760                 765             


Leu Lys Asp Cys Trp Ile Ile Phe His Lys Arg His Phe Ile Ile Arg 
    770                 775                 780                 


Pro Ala Lys Glu Gln Ile Ser Ser Leu Leu Ala Gln Pro Val Val Leu 
785                 790                 795                 800 


Pro Arg Gly Leu Phe Asp Asn Lys Pro Thr Tyr Ile Lys Asp Val Lys 
                805                 810                 815     


Leu Glu Asp Ala Pro Glu Lys Phe Ala Asn Trp Tyr Arg Tyr Thr Tyr 
            820                 825                 830         


Asn Asp Tyr Pro Met Gln Arg Phe Tyr Ser Phe Asp Arg Asp Tyr Thr 
        835                 840                 845             


Ser Leu Tyr Glu Glu Phe Gln Ser Asn Lys Asp Val Ile Leu Asn Lys 
    850                 855                 860                 


Lys Arg Leu Thr Lys Ser Glu Gln Glu Ala Leu Leu Lys Lys Lys Gln 
865                 870                 875                 880 


Asp Leu Lys Ile Lys Asp Ile Arg Thr Gln Asp Leu Phe Leu Lys Leu 
                885                 890                 895     


Ile Ala Asp Lys Leu Phe Glu Asp Ile Phe Asp Gln Lys Ala Asp Phe 
            900                 905                 910         


Thr Leu Glu Asp Ile Tyr Gln Thr Arg Glu Glu Arg Met Gln Asn Gly 
        915                 920                 925             


Glu Gln Ala Leu Gln Gln Ser Glu Arg Ala Pro Gly Asp Asp Phe Glu 
    930                 935                 940                 


Asn Ile Tyr Asn Glu Ser Phe Val Leu Asn Lys Thr Val Pro Phe Ile 
945                 950                 955                 960 


Gln Lys Gln Ile His Glu Pro Thr Val Lys Ile Lys Asp Leu Gly Lys 
                965                 970                 975     


Phe Lys Arg Phe Leu Phe Asp Asn Lys Val Lys Ala Leu Phe Ser Tyr 
            980                 985                 990         


Glu Pro Asn Arg Val Trp Ser Ile  Gln Glu Leu Glu Asn  Glu Leu Thr 
        995                 1000                 1005             


Leu Leu  Pro Thr Ser Tyr Glu  Val Ile Arg Arg Val  Ser Leu Leu 
    1010                 1015                 1020             


Lys Ala  Ile Gln Glu Phe Glu  Lys Tyr Ile Met Glu  Cys Trp Gly 
    1025                 1030                 1035             


Asp Ser  Asp Thr Thr Lys Leu  Asp Gln Lys Asp Lys  Lys Ser Gly 
    1040                 1045                 1050             


Lys Tyr  Asn Pro Ser Phe Lys  Lys Tyr Ile Phe Asn  Gly Val Leu 
    1055                 1060                 1065             


Asp Lys  Phe Arg Leu Ala Asn  Ala Glu Asn Ile Lys  His Ile Ile 
    1070                 1075                 1080             


Asp Tyr  Lys Lys Phe Glu Glu  Leu Val Asp Asp Pro  Gln Leu Lys 
    1085                 1090                 1095             


Ser Phe  Glu Glu Ile Val Arg  Lys Ala Tyr Ile Leu  Thr Ile Ile 
    1100                 1105                 1110             


Arg Asn  Lys Ile Ala His Asn  Gln Leu Pro Asp Lys  Ala Asn Met 
    1115                 1120                 1125             


Asp Phe  Ile Gln Gly Met Tyr  Pro Lys Glu Pro Gln  Asp Ser Tyr 
    1130                 1135                 1140             


Ser Gln  Tyr Leu Leu Arg Val  Thr Gln Leu Ile Ile  Asp Glu Met 
    1145                 1150                 1155             


Val Leu  Leu Met Lys Ile 
    1160                 


<210>  1855
<211>  1081
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1855

Met Gln Ala Gln Ser Leu Phe Asp Glu Tyr Lys His Leu Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Val Met Ser Ile Met Asn Ile Ile Thr Val Leu Asn His Ile 
            20                  25                  30          


His Gln Ile Ala Gly Leu Lys Arg Asn Glu Leu Gly Asp Asp Asp Asn 
        35                  40                  45              


Ile Tyr Ser His Pro Val Leu Lys Tyr Ile Ala Pro Glu Asn Asn Ser 
    50                  55                  60                  


Thr Thr Leu Pro Glu Lys Arg Asp Leu Ile Lys Glu Leu Leu Leu Glu 
65                  70                  75                  80  


Tyr Leu Pro Phe Leu Glu Ala Met Lys Asp Cys Tyr Lys Glu Val Lys 
                85                  90                  95      


Val Glu Lys Asp Lys Arg Asn Asn Lys Tyr Val Lys Asp Lys Lys Gln 
            100                 105                 110         


Val Phe Ile Arg Asn Tyr Ser Asp Ile Tyr Cys Ile Tyr Trp Thr Leu 
        115                 120                 125             


Tyr Asn Ile Phe Ser Thr Leu Ile Asn Tyr Arg Asp Lys Ser Cys His 
    130                 135                 140                 


Tyr Arg Phe Ile Pro Ser Lys Asp Gln Glu Glu Tyr Ser Lys Arg Thr 
145                 150                 155                 160 


Glu Tyr Asp Thr Val Arg Ile Ile Asn Lys Tyr Tyr Thr Tyr Ala Leu 
                165                 170                 175     


Arg Lys Thr Lys Glu Lys Tyr Gly Tyr Thr Thr Glu Gln Leu Ser Phe 
            180                 185                 190         


Ile Gln Asn Asn Arg Tyr Thr Asp Asp Lys Lys Val Asn Phe Asn Phe 
        195                 200                 205             


Phe Leu Ser Met Gln Ser Ser Asn Asn Asn Leu Ser His Val Gly Val 
    210                 215                 220                 


Ala Gln Leu Ile Cys Leu Phe Leu Gln Lys Lys Asp Val Asp Asn Phe 
225                 230                 235                 240 


Leu Glu Asn Leu Pro Ile Tyr Asp Asn Arg Tyr Cys Leu Gly Ile Asp 
                245                 250                 255     


Glu His Met Ile Ile Lys Arg Ser Leu Ala Leu His Ser Ile Lys Leu 
            260                 265                 270         


Pro Lys Glu Arg Leu Asn Ser Glu Lys Lys Asp Met Ala Ile Ala Met 
        275                 280                 285             


Asp Met Leu Asn Glu Leu Lys Arg Cys Pro Lys Glu Leu Phe Asn Thr 
    290                 295                 300                 


Leu Pro Phe Asp Lys Gln Glu Arg Phe Arg Ile Ile Ser Ser Asp His 
305                 310                 315                 320 


Lys Glu Val Leu Leu Met Arg Ser Thr Asp Arg Phe Val Pro Leu Ile 
                325                 330                 335     


Leu Gln Tyr Ile Asp Cys Asn Lys Lys Phe Lys Asp Ile Arg Phe His 
            340                 345                 350         


Val Asn Met Gly Lys Leu Arg Tyr Leu Phe Ser Pro Asn Lys Leu Cys 
        355                 360                 365             


Ile Asp Asn Gln Glu Arg Val Arg Met Leu Glu His Leu Leu Asn Gly 
    370                 375                 380                 


Tyr Gly Arg Ile Asp Glu Val Glu Tyr Leu Arg Lys Ala Pro Asn Gly 
385                 390                 395                 400 


Thr Phe Gly Asn Thr Asn Ile Pro Ile Lys Gly Phe Gly Glu Ile Glu 
                405                 410                 415     


Arg Asp Ser Ala Asp Ser Asn Asn Tyr Pro Tyr Ile Val Asp Thr His 
            420                 425                 430         


Thr His Tyr Ile Leu Asn Asn Asn Lys Val Glu Phe Cys Phe Cys Glu 
        435                 440                 445             


Asp Ser Lys Asn Lys Asn Val Phe Pro Thr Ile Glu Lys Glu Ile Asn 
    450                 455                 460                 


Gly Lys Trp Tyr Val Glu Lys Thr Ala Pro His Cys Arg Ile Ser Phe 
465                 470                 475                 480 


Phe Glu Ile Pro Ala Met Ala Phe His Met Phe Leu Cys Gly Ser Glu 
                485                 490                 495     


Lys Thr Glu Lys Leu Ile Lys Asp Val Tyr Asn Asn Tyr Ile Ser Leu 
            500                 505                 510         


Phe Asn Ala Leu Lys Asn Gly Ala Leu Thr Glu Glu Asn Tyr Lys Asp 
        515                 520                 525             


Phe Asn Ile Pro Glu Cys Asp Met Pro Lys Lys Ile Leu Asp Phe Leu 
    530                 535                 540                 


Lys Gly Lys Ala Glu Gly Lys Ser Ile Asp Gly Tyr Val Lys Asn Ile 
545                 550                 555                 560 


Leu Lys Lys Glu Leu Lys Asp Thr Arg Lys Arg Ile Glu Gln Ala Pro 
                565                 570                 575     


Ser Glu Lys Asp Gln Met Pro Ser Lys Arg Asn Lys Ile Gly Thr Lys 
            580                 585                 590         


Ser Tyr Lys Arg Val Leu Thr Gly Lys Leu Ala Asp Phe Leu Ala Lys 
        595                 600                 605             


Asp Ile Val Lys Tyr Gln Pro Thr Leu Cys Ala Gly Asp Asp Tyr Gly 
    610                 615                 620                 


Ile Asp Arg Met Thr Gly Met Asn Tyr Arg Ile Met Gln Ala Thr Ile 
625                 630                 635                 640 


Ala Thr Tyr Asn Asp Asp Asp Asp Phe Asp Thr Phe Tyr Asn Val Phe 
                645                 650                 655     


Lys Met Ala Gly Leu Val Asp Gly Asp Glu Arg Lys Asn His Pro Phe 
            660                 665                 670         


Leu Lys Lys Val Leu Leu Ser Lys Pro Gln Asn Thr Val Ala Phe Asn 
        675                 680                 685             


Ile Lys Tyr Leu Lys Glu Lys Glu Ile Tyr Leu Arg Asn Ile Glu Lys 
    690                 695                 700                 


Lys Asn Ile Ile Pro Pro Phe Val Asn Arg Glu Arg Asn Lys Trp Cys 
705                 710                 715                 720 


Glu Arg Asp Cys Glu Tyr Tyr Arg Ile Leu Gly Glu Asn Leu Leu Asp 
                725                 730                 735     


Leu Pro Ile Glu Leu Pro Arg Gln Met Phe Tyr Lys Asp Ile Arg Ala 
            740                 745                 750         


Gln Leu Glu Pro Leu Met Pro Glu Ile Asp Phe Ser Gln Thr Asn Thr 
        755                 760                 765             


Thr Tyr Leu Ile Ala Glu Tyr Leu Lys Arg Val Arg Gly Asp Asp Phe 
    770                 775                 780                 


Gln Glu Phe Tyr Ser Trp Glu Arg Asn Tyr Arg Tyr Ile Asp Phe Leu 
785                 790                 795                 800 


Lys Cys Ile Arg Asp Asp Asn Gly Arg Ile Cys Ala Gln Tyr Thr Thr 
                805                 810                 815     


Thr Glu Glu Arg Glu Ser Leu Trp Glu Asp Ser Lys Asn Arg Thr Ala 
            820                 825                 830         


Glu Tyr Lys Arg Ser Glu Glu Gln Lys Asn Glu Lys Lys Asp Lys Asn 
        835                 840                 845             


Phe Glu Asp Ser Leu Glu Glu Arg Ile Ser Ser Ser His Ile Lys Phe 
    850                 855                 860                 


Gln Asn Thr Glu Lys His Ile Arg Arg Tyr Lys Val Gln Asp Ala Leu 
865                 870                 875                 880 


Leu Phe Met Ile Ala Glu Lys Gln Phe Gly Lys Tyr Leu Asp Asp Ile 
                885                 890                 895     


Lys Ala Lys Asn Phe Lys Leu Lys Asp Ile Met Pro Asp Thr Asp Lys 
            900                 905                 910         


Gly Ile Leu Ser Glu Thr Met Pro Ile Asp Phe Thr Phe Thr Lys Lys 
        915                 920                 925             


Asn Ile Lys Tyr Asn Ile His Ala Lys Asn Leu Lys Phe Lys Glu Tyr 
    930                 935                 940                 


Gly Asp Leu Phe Ile Leu Ala Asn Asp Lys Arg Leu Glu Ser Leu Trp 
945                 950                 955                 960 


Lys Ile Leu Ala Thr Asp Thr Val Asn Lys Glu Glu Ile Ser Glu Glu 
                965                 970                 975     


Phe Ala Lys Tyr Asp Phe Cys Arg Pro Asp Ile Thr Lys Leu Val Leu 
            980                 985                 990         


Asp Phe Glu Lys Asp Val Leu Glu  Lys Tyr Pro Glu Ile  Ile Glu Glu 
        995                 1000                 1005             


Ala Glu  Lys Glu Tyr Lys Lys  Phe Asp Phe Lys Phe  Ile Leu Asp 
    1010                 1015                 1020             


Trp Leu  Ile Asn Lys Lys Lys  Leu Asn Tyr Gly Ile  Arg Asn Lys 
    1025                 1030                 1035             


Leu Leu  Leu Ile Arg Asn Ala  Phe Asn His Asn Ser  Tyr Pro Asp 
    1040                 1045                 1050             


Lys Lys  Tyr Ala Glu Val Arg  Glu Leu Pro Glu Ile  Ala Thr Asn 
    1055                 1060                 1065             


Leu Lys  Lys Thr Phe Asp Glu  Asn Ala Lys Lys Tyr  Glu 
    1070                 1075                 1080     


<210>  1856
<211>  1081
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1856

Met Gln Ala Gln Ser Leu Phe Asp Glu Tyr Lys His Leu Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Val Met Ser Ile Met Asn Ile Ile Thr Val Leu Asn His Ile 
            20                  25                  30          


His Gln Ile Ala Gly Leu Lys Arg Asn Glu Leu Gly Asp Asp Asp Asn 
        35                  40                  45              


Ile Tyr Ser His Pro Val Leu Lys Tyr Ile Ala Pro Glu Asn Asn Ser 
    50                  55                  60                  


Thr Thr Leu Pro Glu Lys Arg Asp Leu Ile Lys Glu Leu Leu Leu Glu 
65                  70                  75                  80  


Tyr Leu Pro Phe Leu Glu Ala Met Lys Asp Cys Tyr Lys Glu Val Lys 
                85                  90                  95      


Val Glu Lys Asp Lys Arg Asn Asn Lys Tyr Val Lys Asp Lys Lys Gln 
            100                 105                 110         


Val Phe Ile Arg Asn Tyr Ser Asp Ile Tyr Cys Ile Tyr Trp Thr Leu 
        115                 120                 125             


Tyr Asn Ile Phe Ser Thr Leu Ile Asn Tyr Arg Asp Lys Ser Cys His 
    130                 135                 140                 


Tyr Arg Phe Ile Pro Ser Lys Asp Gln Glu Glu Tyr Ser Lys Arg Thr 
145                 150                 155                 160 


Glu Tyr Asp Thr Val Arg Ile Ile Asn Lys Tyr Tyr Thr Tyr Ala Leu 
                165                 170                 175     


Arg Lys Thr Lys Glu Lys Tyr Gly Tyr Thr Thr Glu Gln Leu Ser Phe 
            180                 185                 190         


Ile Gln Asn Asn Arg Tyr Thr Asp Asp Lys Lys Val Asn Phe Asn Phe 
        195                 200                 205             


Phe Leu Ser Met Gln Ser Ser Asn Asn Asn Leu Ser His Val Gly Val 
    210                 215                 220                 


Ala Gln Leu Ile Cys Leu Phe Leu Gln Lys Lys Asp Val Asp Asn Phe 
225                 230                 235                 240 


Leu Glu Asn Leu Pro Ile Tyr Asp Asn Arg Tyr Cys Leu Gly Ile Asp 
                245                 250                 255     


Glu His Met Ile Ile Lys Arg Ser Leu Ala Leu His Ser Ile Lys Leu 
            260                 265                 270         


Pro Lys Glu Arg Leu Asn Ser Glu Lys Lys Asp Met Ala Ile Ala Met 
        275                 280                 285             


Asp Met Leu Asn Glu Leu Lys Arg Cys Pro Lys Glu Leu Phe Asn Thr 
    290                 295                 300                 


Leu Pro Phe Asp Lys Gln Glu Arg Phe Arg Ile Ile Ser Ser Asp His 
305                 310                 315                 320 


Lys Glu Val Leu Leu Met Arg Ser Thr Asp Arg Phe Val Pro Leu Ile 
                325                 330                 335     


Leu Gln Tyr Ile Asp Cys Asn Lys Lys Phe Lys Asp Ile Arg Phe His 
            340                 345                 350         


Val Asn Met Gly Lys Leu Arg Tyr Leu Phe Ser Pro Asn Lys Leu Cys 
        355                 360                 365             


Ile Asp Asn Gln Glu Arg Val Arg Met Leu Glu His Leu Leu Asn Gly 
    370                 375                 380                 


Tyr Gly Arg Ile Asp Glu Val Glu Tyr Leu Arg Lys Ala Pro Asn Gly 
385                 390                 395                 400 


Thr Phe Gly Asn Thr Asn Ile Pro Ile Lys Gly Phe Gly Glu Ile Glu 
                405                 410                 415     


Arg Asp Ser Ala Asp Ser Asn Asn Tyr Pro Tyr Ile Val Asp Thr His 
            420                 425                 430         


Thr His Tyr Ile Leu Asn Asn Asn Lys Val Glu Phe Cys Phe Cys Glu 
        435                 440                 445             


Asp Ser Lys Asn Lys Asn Val Phe Pro Thr Ile Glu Lys Glu Ile Asn 
    450                 455                 460                 


Gly Lys Trp Tyr Val Glu Lys Thr Ala Pro His Cys Arg Ile Ser Phe 
465                 470                 475                 480 


Phe Glu Ile Pro Ala Met Ala Phe His Met Phe Leu Cys Gly Ser Glu 
                485                 490                 495     


Lys Thr Glu Lys Leu Ile Lys Asp Val Tyr Asn Asn Tyr Ile Ser Leu 
            500                 505                 510         


Phe Asn Ala Leu Lys Asn Gly Ala Leu Thr Glu Glu Asn Tyr Lys Asp 
        515                 520                 525             


Phe Asn Ile Pro Glu Cys Asp Met Pro Lys Lys Ile Leu Asp Phe Leu 
    530                 535                 540                 


Lys Gly Lys Ala Glu Gly Lys Ser Ile Asp Gly Tyr Val Lys Asn Ile 
545                 550                 555                 560 


Leu Lys Lys Glu Leu Lys Asp Thr Arg Lys Arg Ile Glu Gln Ala Pro 
                565                 570                 575     


Ser Glu Lys Asp Gln Met Pro Ser Lys Arg Asn Lys Ile Gly Thr Lys 
            580                 585                 590         


Ser Tyr Lys Arg Val Leu Thr Gly Lys Leu Ala Asp Phe Leu Ala Lys 
        595                 600                 605             


Asp Ile Val Lys Tyr Gln Pro Thr Leu Cys Ala Gly Asp Asp Tyr Gly 
    610                 615                 620                 


Ile Asp Arg Met Thr Gly Met Asn Tyr Arg Ile Met Gln Ala Thr Ile 
625                 630                 635                 640 


Ala Thr Tyr Asn Asp Asp Asp Asp Phe Asp Thr Phe Tyr Asn Val Phe 
                645                 650                 655     


Lys Met Ala Gly Leu Val Asp Gly Asp Glu Arg Lys Asn His Pro Phe 
            660                 665                 670         


Leu Lys Lys Val Leu Leu Ser Lys Pro Gln Asn Thr Val Ala Phe Asn 
        675                 680                 685             


Ile Lys Tyr Leu Lys Glu Lys Glu Ile Tyr Leu Arg Asn Ile Glu Lys 
    690                 695                 700                 


Lys Asn Ile Ile Pro Pro Phe Val Asn Arg Glu Arg Asn Lys Trp Cys 
705                 710                 715                 720 


Glu Arg Asp Cys Glu Tyr Tyr Arg Ile Leu Gly Glu Asn Leu Leu Asp 
                725                 730                 735     


Leu Pro Ile Glu Leu Pro Arg Gln Met Phe Tyr Lys Asp Ile Arg Ala 
            740                 745                 750         


Gln Leu Glu Pro Leu Met Pro Glu Ile Asp Phe Ser Gln Thr Asn Thr 
        755                 760                 765             


Thr Tyr Leu Ile Ala Glu Tyr Leu Lys Arg Val Arg Gly Asp Asp Phe 
    770                 775                 780                 


Gln Glu Phe Tyr Ser Trp Glu Arg Asn Tyr Arg Tyr Ile Asp Phe Leu 
785                 790                 795                 800 


Lys Cys Ile Arg Asp Asp Asn Gly Arg Ile Cys Ala Gln Tyr Thr Thr 
                805                 810                 815     


Thr Glu Glu Arg Glu Ser Leu Trp Glu Asp Ser Lys Asn Arg Thr Ala 
            820                 825                 830         


Glu Tyr Lys Arg Ser Glu Glu Gln Lys Asn Glu Lys Lys Asp Lys Asn 
        835                 840                 845             


Phe Glu Asp Ser Leu Glu Glu Arg Ile Ser Ser Ser His Ile Lys Phe 
    850                 855                 860                 


Gln Asn Thr Glu Lys His Ile Arg Arg Tyr Lys Val Gln Asp Ala Leu 
865                 870                 875                 880 


Leu Phe Met Ile Ala Glu Lys Gln Phe Gly Lys Tyr Leu Asp Asp Ile 
                885                 890                 895     


Lys Ala Lys Asn Phe Lys Leu Lys Asp Ile Met Pro Asp Thr Asp Lys 
            900                 905                 910         


Gly Ile Leu Ser Glu Thr Met Pro Ile Asp Phe Thr Phe Thr Lys Lys 
        915                 920                 925             


Asn Ile Lys Tyr Asn Ile His Ala Lys Asn Leu Lys Phe Lys Glu Tyr 
    930                 935                 940                 


Gly Asp Leu Phe Ile Leu Ala Asn Asp Lys Arg Leu Glu Ser Leu Trp 
945                 950                 955                 960 


Lys Ile Leu Ala Thr Asp Thr Val Asn Lys Glu Glu Ile Ser Glu Glu 
                965                 970                 975     


Phe Ala Lys Tyr Asp Phe Cys Arg Pro Asp Ile Thr Lys Leu Val Leu 
            980                 985                 990         


Asp Phe Glu Lys Asp Val Leu Glu  Lys Tyr Pro Glu Ile  Ile Glu Glu 
        995                 1000                 1005             


Ala Glu  Lys Glu Tyr Lys Lys  Phe Asp Phe Lys Phe  Ile Leu Asp 
    1010                 1015                 1020             


Trp Leu  Ile Asn Lys Lys Lys  Leu Asn Tyr Gly Ile  Arg Asn Lys 
    1025                 1030                 1035             


Leu Leu  Leu Ile Arg Asn Ala  Phe Asn His Asn Ser  Tyr Pro Asp 
    1040                 1045                 1050             


Lys Lys  Tyr Ala Glu Val Arg  Glu Leu Pro Glu Ile  Ala Thr Asn 
    1055                 1060                 1065             


Leu Lys  Lys Thr Phe Asp Glu  Asn Ala Lys Lys Tyr  Glu 
    1070                 1075                 1080     


<210>  1857
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1857

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Thr 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1858
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1858

Met Asn Thr His Gln Glu Glu Leu Gln Ser Trp Ile Thr Arg Lys Arg 
1               5                   10                  15      


Leu Pro Asp Thr Glu Met Lys Lys Tyr Trp Ala Ala Tyr Met Asn Leu 
            20                  25                  30          


Ala Arg Leu Asn Phe Phe Lys Thr Leu Met Phe Ile Ser Asn Ser Ile 
        35                  40                  45              


Gly Asp Leu Lys Pro Ala Lys Asp Asn Asn Gly Lys Gly Asn Thr Glu 
    50                  55                  60                  


Val Asn Met His Asn Met Gly Ile Leu Thr Ala Leu Leu Gly Pro Glu 
65                  70                  75                  80  


Asp Glu Glu Lys Ala Arg Leu Leu Ile Phe Lys His Phe Pro Phe Leu 
                85                  90                  95      


Arg Thr Phe Cys Ile Glu Lys Glu Leu Ser Leu Ser Lys Gln Arg Thr 
            100                 105                 110         


Ile Leu Ile Asp Met Ala Cys Ile Ile Gly Arg Tyr Arg Asn Met Tyr 
        115                 120                 125             


Ser His Ser Ile Phe Ile Ser Asp Asp Asn Glu Lys Val Leu Glu Ser 
    130                 135                 140                 


Glu Lys Arg Cys Ser Glu Tyr Leu Gln Ser Ile Leu Thr Val Ser Thr 
145                 150                 155                 160 


Arg Ile Ile Lys Glu Arg Tyr Arg Ser Asn Lys Asn Asp Ala Gln Arg 
                165                 170                 175     


Gly Met Ile Asp Asp Lys Ser Leu Glu Phe Ile Ser Glu Asn Lys Val 
            180                 185                 190         


Lys Phe Val Tyr Asp Glu Asn Gly Lys Arg Ile Thr Ala Pro Asn Lys 
        195                 200                 205             


Lys Tyr Tyr Leu Ser Thr Ile Asp Lys Asp Asn Thr His Leu Ser Tyr 
    210                 215                 220                 


Phe Gly Lys Leu Met Leu Thr Cys Ile Leu Leu Glu Lys Lys Tyr Ala 
225                 230                 235                 240 


Thr Ala Phe Leu Thr Gln Cys His Phe Leu Asp Ala Phe Asn Asp Ser 
                245                 250                 255     


Glu Val Ala Pro Lys Leu Ser Glu Arg Arg Leu Met Leu Glu Val Met 
            260                 265                 270         


Thr Ala Leu Arg Ile Arg Leu Ala Glu Lys Lys Leu Ser Asn Glu Lys 
        275                 280                 285             


Ser Glu Val Gln Ile Ser Leu Asp Ile Leu Asn Glu Leu Lys Lys Cys 
    290                 295                 300                 


Pro Phe Glu Leu Tyr Glu Leu Leu Gly Ser Glu Asp Lys Arg Leu Phe 
305                 310                 315                 320 


Thr Ile Val Ala Asp Thr Gly Glu Thr Ile Leu Leu Arg Arg His Glu 
                325                 330                 335     


Asp Arg Phe Pro Gln Leu Ala Leu Ser Trp Ile Asp Ser Ser Lys Ala 
            340                 345                 350         


Phe Asp His Leu Arg Phe Gln Val Asn Ala Gly Lys Leu Arg Tyr Leu 
        355                 360                 365             


Phe Arg Asp Asn Lys His Cys Ile Asp Gly Gln Thr Arg Met Arg Val 
    370                 375                 380                 


Leu Glu Glu Pro Leu Asn Gly Tyr Arg Arg Leu Met Glu Phe Glu Glu 
385                 390                 395                 400 


Glu Arg Ile Gln Lys Gln Ser Gly Glu Ile Arg Ser Leu Trp Pro Gly 
                405                 410                 415     


Leu Asp Ile Leu Asn Lys Asp Glu Thr Pro Arg Asn Asp Ala Ser Val 
            420                 425                 430         


Leu Pro Tyr Ile Ser Asp Tyr Arg Val Arg Tyr Leu Phe Asp Gly Asp 
        435                 440                 445             


Asn Ile Gly Ile Ser Ile Gly Asp Phe Thr Pro Ser Ile Thr Lys Thr 
    450                 455                 460                 


Asp Glu Thr Lys Tyr Arg Val Thr Gly Lys Thr Ala Asp Cys Cys Leu 
465                 470                 475                 480 


Ser Lys Tyr Glu Leu Pro Gly Leu Leu Phe Tyr His Leu Leu Thr Leu 
                485                 490                 495     


Arg His Gly Asp Asn Lys Arg Ser Thr Lys Asn Ala Glu Asp Ile Ile 
            500                 505                 510         


Ile Asp Ala Ile Lys Arg Tyr Lys Arg Leu Phe Ser Asp Val Lys Glu 
        515                 520                 525             


Gly Ile Leu Lys Pro Ile Lys Glu Glu Asn Ala Asn Gln Leu Gly Asn 
    530                 535                 540                 


Arg Ile Trp Asn Ser Tyr Gly Ile Asp Ile Lys Asp Ile Pro Asp Lys 
545                 550                 555                 560 


Ile Ile Asp Tyr Leu Leu Val Arg Glu Cys Asn Glu Asp Glu Lys Phe 
                565                 570                 575     


Thr Ala Trp Lys Asn Gly Leu Ile Ser Glu Met Leu Gln Ser Thr Lys 
            580                 585                 590         


Asn Arg Ile Lys Arg Phe Glu Lys Asp Ser Glu Ala Val Ile Ser Ser 
        595                 600                 605             


Asp Asn Lys Pro Gly Lys Lys Asn His Val Ser Leu Lys Pro Gly Ala 
    610                 615                 620                 


Tyr Ala Ser Phe Ile Ala Asn Asp Ile Val Phe Phe Gln Glu Cys Gly 
625                 630                 635                 640 


Ala Thr Glu Lys Met Thr Gly Leu Asn Phe Lys Val Met Gln Ser Arg 
                645                 650                 655     


Leu Ala Thr Phe Thr Lys Asp Gly Ser Thr Ser Phe Asn Ile Leu Leu 
            660                 665                 670         


Gln Thr Leu Lys Asn Ala His Leu Val Ser Asn Thr Tyr Gly Lys Gly 
        675                 680                 685             


Asp His Pro Phe Leu Tyr Arg Val Ile Lys Gln Gln Pro Ser Asp Ile 
    690                 695                 700                 


Val Gln Phe Tyr Lys Ile Tyr Leu Asn Glu Lys Val Leu Tyr Leu Gln 
705                 710                 715                 720 


Ser Asp Ile Pro Asp Asn Ala Ile Phe Leu His Gly Glu Arg Lys Arg 
                725                 730                 735     


Trp Glu Asn Arg Asn Glu Gln Tyr Tyr Arg Asp Leu Ala Glu Arg Tyr 
            740                 745                 750         


Leu Gln Arg Pro Ile Gln Leu Pro Arg Gln Leu Phe Glu Ser His Ile 
        755                 760                 765             


Arg Gln Leu Leu Leu Ser Asp Cys Ile Lys Gly Glu Arg Gly Asn Asp 
    770                 775                 780                 


Leu Lys Glu Ala Ile Asn Ser Ala Ala Ser Gln Gly Arg Cys Asn Thr 
785                 790                 795                 800 


Thr Tyr Met Ile Met Glu Tyr Phe Ala Asp Tyr Leu Cys Asp Gly Thr 
                805                 810                 815     


Gln Phe Phe Tyr Gly Leu Phe Asp Gly Asp Leu Ser His Glu Tyr Asn 
            820                 825                 830         


Tyr Arg Phe Tyr Ser Leu Ile Ser Asn Asn Ile Glu Asn Ser Lys Lys 
        835                 840                 845             


Leu Val Leu Thr Leu Lys Lys Gly Asn Asn Ser Lys Glu Ser Pro Phe 
    850                 855                 860                 


Ile Ser Ala Leu Glu Arg Gly Ile His Trp Ser Lys Met Asn Pro Leu 
865                 870                 875                 880 


Met Lys Lys Gly Leu Lys Asn Asp Ser Ser Glu Gly Asp Phe Val His 
                885                 890                 895     


Ala Ala Lys Arg Ala Tyr Lys Glu Met Thr Glu Thr Glu Arg Met Phe 
            900                 905                 910         


Arg Arg Tyr Ala Val Gln Asp Glu Val Leu Phe Leu Ala Ala Lys Ile 
        915                 920                 925             


Thr Ile Arg Arg Ala Leu Gly Leu Ser Glu Gln Tyr Asn Cys Leu Leu 
    930                 935                 940                 


Gly Asp Ile Lys Pro Gln Gly Gly Ser Leu Leu Glu Gln Thr Ile Pro 
945                 950                 955                 960 


Ser Ile Thr Thr Lys His Thr Ile Asn Thr Gly Asn Lys Lys Gln Lys 
                965                 970                 975     


Pro Lys Gln Val Gln Ile Leu Gln Lys Asn Val Lys Leu Lys Asp Phe 
            980                 985                 990         


Gly Lys Val Phe Lys Leu Leu Asn  Asp Arg Arg Ile Phe  Asp Leu Leu 
        995                 1000                 1005             


Phe Asn  Lys Gly Asn Glu Ala  Val Ser Met Thr Asp  Leu Cys Glu 
    1010                 1015                 1020             


Glu Leu  Glu Arg Tyr Asp Arg  His Arg Val Asp Val  Phe Asp Ser 
    1025                 1030                 1035             


Val Leu  Lys Tyr Glu Ser Lys  Ile Thr Lys Gly Tyr  Thr Asn Lys 
    1040                 1045                 1050             


Glu Leu  Met Asn Glu Ser Gly  Gln Ile Asp Phe Lys  Ala Ile Gln 
    1055                 1060                 1065             


Ala Phe  Asp Lys Gln Asn Thr  Thr Ser Asp Lys Glu  Asp Leu Arg 
    1070                 1075                 1080             


Leu Ile  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Gln Tyr Asn 
    1085                 1090                 1095             


Asn Glu  Pro Ile Leu Phe Asp  Lys Asp Ile Pro Glu  Ile Ala Asp 
    1100                 1105                 1110             


Glu Ile  Ser Ile Ile Ala Lys  Asp Ile Glu Glu Asn  Thr Lys 
    1115                 1120                 1125         


<210>  1859
<211>  1150
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1859

Met Lys Thr Ile Phe Ala Gln Asn Ser Ile Asn Lys Leu Phe Gln His 
1               5                   10                  15      


Lys Gly Lys Ile Ala Pro Ile Ala Glu Lys Ala Asn Ile Asn Phe Lys 
            20                  25                  30          


Leu Lys Ser Asn Asn Pro Asn Gly Leu Ser Glu Asp Phe Ile Lys Ser 
        35                  40                  45              


Arg Leu His Tyr Phe Ser Ile Gly His Ser Phe Lys Gln Ile Asp Thr 
    50                  55                  60                  


Lys Gln Val Phe Gly Gln Thr Asp Glu Gly Glu Arg Lys Phe Phe Lys 
65                  70                  75                  80  


Asn Leu Gln Leu Glu Asn Phe Pro Asn Lys Asp Thr Phe Lys Thr Leu 
                85                  90                  95      


Ile Asn Asp Leu Arg Asn Ile Asn Ser His Tyr Ile His Asp Phe Glu 
            100                 105                 110         


Lys Ile Lys Ile Glu Lys Ile Glu Pro Leu Lys His Phe Leu Ile Glu 
        115                 120                 125             


Ala Phe Ser Leu Ala Ile Lys Met Ser Tyr Leu Lys Leu Glu Thr Ser 
    130                 135                 140                 


Lys Lys Ala Ser Phe Val Tyr Ser Asp Ile Thr Asp Asn Asn Leu Met 
145                 150                 155                 160 


His Phe Leu Ser Asp Lys Phe Phe Pro Asn His Glu Phe Gln Ile Glu 
                165                 170                 175     


Glu Arg Ala Tyr Phe Lys Lys Leu Ser Tyr Asp Lys Ala Leu Glu Tyr 
            180                 185                 190         


Leu Leu Phe Ile Glu Leu Asp Glu His Tyr Asp Trp Lys Asn Tyr Lys 
        195                 200                 205             


Glu Ser Asn His Val Val Phe Thr Ile Ala Lys Gly Thr Tyr Leu Ser 
    210                 215                 220                 


Phe Tyr Gly Ser Leu Phe Cys Leu Ser Met Phe Leu Tyr Arg Gly Glu 
225                 230                 235                 240 


Ala Arg Thr Met Ile Ser Lys Ile Lys Gly Phe Lys Lys Asn Ala Thr 
                245                 250                 255     


Glu Asp Glu Arg Val Lys Leu Asp Ile Phe Thr Phe Phe Ala Lys Lys 
            260                 265                 270         


Phe Ser Ser Gln Asp Ala Asp Ala Glu Glu Lys His Leu Val Lys Phe 
        275                 280                 285             


Arg Asp Ile Val Gln Tyr Leu Asn Gln Tyr Pro Thr Ala Trp Asn Lys 
    290                 295                 300                 


Glu Leu Glu Leu Glu Ser Ser Val Pro Lys Met Thr Glu Ala Leu Asn 
305                 310                 315                 320 


Lys Glu Leu Glu Leu Thr Ser Ser Val Pro Lys Met Thr Glu Ala Leu 
                325                 330                 335     


Thr Glu Tyr Val Lys Glu Glu Glu Ile Gln Arg Cys Tyr Glu Asp Met 
            340                 345                 350         


Tyr Ala Val Gly Asn Phe Lys Glu Tyr Ala Leu His Tyr Phe Trp Gln 
        355                 360                 365             


Arg Pro Lys Pro Ser Ile Asn Ala Lys Thr Glu Lys Asp Phe Leu Tyr 
    370                 375                 380                 


Glu Ile Gln Thr Pro Glu Ser Val Lys Lys Leu Glu Glu Glu Ile Arg 
385                 390                 395                 400 


Lys Leu Glu Ser Asp Leu Lys Lys Lys Tyr Asp Tyr Glu Lys Glu Lys 
                405                 410                 415     


Ala Leu Lys Ser Ala Asn Phe Ser Leu Lys Lys Leu Lys Glu Lys Asn 
            420                 425                 430         


Leu Pro Asn Thr Lys Leu Leu Lys Leu Gln Lys Arg Ile Ala Asn His 
        435                 440                 445             


Ser Leu Ile Arg Ser Tyr Gly Arg Asn Ile Asp Arg Phe Met Glu Met 
    450                 455                 460                 


Gly Leu Arg Tyr Leu Ala Glu Asn Gln Cys Phe Gly Glu Tyr Thr Gln 
465                 470                 475                 480 


Phe Arg Leu Tyr Lys Tyr Phe Ser Pro Glu Asp Glu Arg Leu Lys Pro 
                485                 490                 495     


Glu Glu Lys His Leu Thr Lys Lys Glu Phe Asp Lys Leu Lys Tyr His 
            500                 505                 510         


Glu Gly Lys Leu Thr His Phe Thr Thr Tyr Gln Glu His Ile Asn Lys 
        515                 520                 525             


Tyr Gln Asp Trp Asp Met Pro Phe Val Ile Glu Asn Asn Ala Thr Gln 
    530                 535                 540                 


Ile Arg Phe Ser Val Gly Gly Asp Phe Tyr Thr Val Ser Ile Gln Arg 
545                 550                 555                 560 


Asn Leu Leu Val Tyr Leu Leu Glu Ile Ala Phe Tyr Ser Ser Gln Ile 
                565                 570                 575     


Thr Cys His Lys Val Leu Gln Glu Tyr Ile Leu Gln Asn Leu Met Asp 
            580                 585                 590         


Lys Lys Glu Ser Val Ser Leu Leu Asn Thr Asn Thr Pro Phe Ser Lys 
        595                 600                 605             


Ile Glu Leu Ala Lys Leu Arg Lys Leu Ile Pro Ser Arg Val Ile Gln 
    610                 615                 620                 


Asp Lys Leu His Leu Pro Asn Glu Arg Lys Ser Asp Tyr Glu Asn Tyr 
625                 630                 635                 640 


Thr Leu Ile Leu Asp Gln Ala Thr Ile Gln Glu Ile Arg Tyr Gln Ala 
                645                 650                 655     


Leu Val Glu Lys Ala Lys Lys Asp Asn Val Leu Glu Phe Phe Leu Lys 
            660                 665                 670         


Arg Asn Lys Gly Lys Asn Phe Lys Leu Arg Phe Val Lys Lys Ala Trp 
        675                 680                 685             


Asn Leu Leu Phe Phe Lys Asn Ala Tyr Val Ala Gln Leu Glu Glu Asn 
    690                 695                 700                 


Lys Asn Lys His His Lys His Tyr His Ile Thr Lys Asp Glu Phe Asp 
705                 710                 715                 720 


Asn Phe Cys Lys Trp Met Tyr Ala Phe Glu Glu Ile Pro Phe Tyr Lys 
                725                 730                 735     


Leu Glu Leu Glu Lys Leu Leu Asn Gln Lys Gly Phe Leu Asn Asn Val 
            740                 745                 750         


Glu Phe Lys Asn Ile Phe Asp Ile Gly Lys Ser Leu Asp Asp Tyr Tyr 
        755                 760                 765             


Thr Ser Thr Lys Lys Leu Tyr Thr Asn Trp Leu Glu Thr Asn Lys Val 
    770                 775                 780                 


Ala Ala Glu Ser Ser Lys Gln Leu Phe Glu Ile His Lys Tyr Lys Asn 
785                 790                 795                 800 


Tyr Glu Glu Pro Asn Lys His Leu Leu Tyr Ile Asn Thr Ser His Phe 
                805                 810                 815     


Ile Glu Phe Leu Lys Ser Lys Lys Trp Leu Gln Leu Thr Asp Ser Lys 
            820                 825                 830         


Ile Val Tyr Thr Ser Leu Asn Asn Ala Lys Tyr Leu Arg Thr Pro Tyr 
        835                 840                 845             


Tyr Tyr Thr Asp Ile Leu Gln Lys Glu Glu Tyr Lys Thr His Ala Asn 
    850                 855                 860                 


Leu Phe Asn Lys Leu Arg Thr His Arg Leu Glu Asp Cys Leu Leu Phe 
865                 870                 875                 880 


Glu Ile Gly Gln Arg Tyr Ile Ser Lys Asn Leu Ser Lys Ala Asn Lys 
                885                 890                 895     


Ile Glu Ser Val Lys Ile Leu Leu Ser Ser Ala Tyr Asp Phe Glu Ile 
            900                 905                 910         


Lys Pro Lys Asp Asn Phe Ser Ala Ser Tyr Tyr Ile Asn Ile Pro Phe 
        915                 920                 925             


Asn Lys Ile Asp Ala Phe Ser Glu Trp Asn His Ala Lys Asn Gln Gly 
    930                 935                 940                 


Glu Thr Gly Lys Tyr Asp Val His Phe Leu Ser Lys Leu Pro Leu Tyr 
945                 950                 955                 960 


Leu Glu Asn Tyr Gly Tyr Met Leu Gly Asn Lys Ser Ser Ile Ala Gln 
                965                 970                 975     


Lys Trp Lys Thr Gln Asn His Pro Lys Thr Ile Asp Tyr Ala Asp Leu 
            980                 985                 990         


Asn Thr Val Asn Met His Ile Met  Asn Thr Ala Ala Thr  Phe Thr Glu 
        995                 1000                 1005             


Ile Gly  Ile Glu Met Glu Arg  Tyr Leu Ile Glu Lys  Tyr Thr Leu 
    1010                 1015                 1020             


Lys Leu  Lys Ser Tyr Asn Ile  Asp Val Lys Asp Ile  Thr Asp Tyr 
    1025                 1030                 1035             


Asp Lys  Tyr Phe Tyr Phe Ile  Gln Asn Ala Lys Lys  Glu Lys Ile 
    1040                 1045                 1050             


Tyr Pro  Asp Arg Asn Asn Ala  Phe His Phe Asn Ile  Ala Ser Lys 
    1055                 1060                 1065             


Pro Tyr  Lys Phe Leu Leu Glu  Asp Val His Lys Lys  Phe Ile Ile 
    1070                 1075                 1080             


Glu Lys  Ile Lys Thr Lys Gln  Tyr Asp Asn Phe Asp  Ala Val Pro 
    1085                 1090                 1095             


Pro Ile  Glu Lys Thr Ile Leu  Lys Met Phe Leu Lys  Glu Leu Phe 
    1100                 1105                 1110             


Asp His  Cys Tyr Asp Arg Asn  Asn Lys Ala Lys Thr  Glu Ile Glu 
    1115                 1120                 1125             


Lys Arg  Arg Lys Leu Glu Asp  Ala Ile Asn Lys Tyr  Trp Gln Lys 
    1130                 1135                 1140             


Glu Val  Lys Lys Tyr Leu Ile  
    1145                 1150 


<210>  1860
<211>  1081
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1860

Met Gln Ala Gln Ser Leu Phe Asp Glu Tyr Lys His Leu Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Val Met Ser Ile Met Asn Ile Ile Thr Val Leu Asn His Ile 
            20                  25                  30          


His Gln Ile Ala Gly Leu Lys Arg Asn Glu Leu Gly Asp Asp Asp Asn 
        35                  40                  45              


Ile Tyr Ser His Pro Val Leu Lys Tyr Ile Ala Pro Glu Asn Asn Ser 
    50                  55                  60                  


Thr Thr Leu Pro Glu Lys Arg Asp Leu Ile Lys Glu Leu Leu Leu Glu 
65                  70                  75                  80  


Tyr Leu Pro Phe Leu Glu Ala Met Lys Asp Cys Tyr Lys Glu Val Lys 
                85                  90                  95      


Val Glu Lys Asp Lys Arg Asn Asn Lys Tyr Val Lys Asp Lys Lys Gln 
            100                 105                 110         


Val Phe Ile Arg Asn Tyr Ser Asp Ile Tyr Cys Ile Tyr Trp Thr Leu 
        115                 120                 125             


Tyr Asn Ile Phe Ser Thr Leu Ile Asn Tyr Arg Asp Lys Ser Cys His 
    130                 135                 140                 


Tyr Arg Phe Ile Pro Ser Lys Asp Gln Glu Glu Tyr Ser Lys Arg Thr 
145                 150                 155                 160 


Glu Tyr Asp Thr Val Arg Ile Ile Asn Lys Tyr Tyr Thr Tyr Ala Leu 
                165                 170                 175     


Arg Lys Thr Lys Glu Lys Tyr Gly Tyr Thr Thr Glu Gln Leu Ser Phe 
            180                 185                 190         


Ile Gln Asn Asn Arg Tyr Thr Asp Asp Lys Lys Val Asn Phe Asn Phe 
        195                 200                 205             


Phe Leu Ser Met Gln Ser Ser Asn Asn Asn Leu Ser His Val Gly Val 
    210                 215                 220                 


Ala Gln Leu Ile Cys Leu Phe Leu Gln Lys Lys Asp Val Asp Asn Phe 
225                 230                 235                 240 


Leu Glu Asn Leu Pro Ile Tyr Asp Asn Arg Tyr Cys Leu Gly Ile Asp 
                245                 250                 255     


Glu His Met Ile Ile Lys Arg Ser Leu Ala Leu His Ser Ile Lys Leu 
            260                 265                 270         


Pro Lys Glu Arg Leu Asn Ser Glu Lys Lys Asp Met Ala Ile Ala Met 
        275                 280                 285             


Asp Met Leu Asn Glu Leu Lys Arg Cys Pro Lys Glu Leu Phe Asn Thr 
    290                 295                 300                 


Leu Pro Phe Asp Lys Gln Glu Arg Phe Arg Ile Ile Ser Ser Asp His 
305                 310                 315                 320 


Lys Glu Val Leu Leu Met Arg Ser Thr Asp Arg Phe Val Pro Leu Ile 
                325                 330                 335     


Leu Gln Tyr Ile Asp Cys Asn Lys Lys Phe Lys Asp Ile Arg Phe His 
            340                 345                 350         


Val Asn Met Gly Lys Leu Arg Tyr Leu Phe Ser Pro Asn Lys Leu Cys 
        355                 360                 365             


Ile Asp Asn Gln Glu Arg Val Arg Met Leu Glu His Leu Leu Asn Gly 
    370                 375                 380                 


Tyr Gly Arg Ile Asp Glu Val Glu Tyr Leu Arg Lys Ala Pro Asn Gly 
385                 390                 395                 400 


Thr Phe Gly Asn Thr Asn Ile Pro Ile Lys Gly Phe Gly Glu Ile Glu 
                405                 410                 415     


Arg Asp Ser Ala Asp Ser Asn Asn Tyr Pro Tyr Ile Val Asp Thr His 
            420                 425                 430         


Thr His Tyr Ile Leu Asn Asn Asn Lys Val Glu Phe Cys Phe Cys Glu 
        435                 440                 445             


Asp Ser Lys Asn Lys Asn Val Phe Pro Thr Ile Glu Lys Glu Ile Asn 
    450                 455                 460                 


Gly Lys Trp Tyr Val Glu Lys Thr Ala Pro His Cys Arg Ile Ser Phe 
465                 470                 475                 480 


Phe Glu Ile Pro Ala Met Ala Phe His Met Phe Leu Cys Gly Ser Glu 
                485                 490                 495     


Lys Thr Glu Lys Leu Ile Lys Asp Val Tyr Asn Asn Tyr Ile Ser Leu 
            500                 505                 510         


Phe Asn Ala Leu Lys Asn Gly Ala Leu Thr Glu Glu Asn Tyr Lys Asp 
        515                 520                 525             


Phe Asn Ile Pro Glu Cys Asp Met Pro Lys Lys Ile Leu Asp Phe Leu 
    530                 535                 540                 


Lys Gly Lys Ala Glu Gly Lys Ser Ile Asp Gly Tyr Val Lys Asn Ile 
545                 550                 555                 560 


Leu Lys Lys Glu Leu Lys Asp Thr Arg Lys Arg Ile Glu Gln Ala Pro 
                565                 570                 575     


Ser Glu Lys Asp Gln Met Pro Ser Lys Arg Asn Lys Ile Gly Thr Lys 
            580                 585                 590         


Ser Tyr Lys Arg Val Leu Thr Gly Lys Leu Ala Asp Phe Leu Ala Lys 
        595                 600                 605             


Asp Ile Val Lys Tyr Gln Pro Thr Leu Cys Ala Gly Asp Asp Tyr Gly 
    610                 615                 620                 


Ile Asp Arg Met Thr Gly Met Asn Tyr Arg Ile Met Gln Ala Thr Ile 
625                 630                 635                 640 


Ala Thr Tyr Asn Asp Asp Asp Asp Phe Asp Thr Phe Tyr Asn Val Phe 
                645                 650                 655     


Lys Met Ala Gly Leu Val Asp Gly Asp Glu Arg Lys Asn His Pro Phe 
            660                 665                 670         


Leu Lys Lys Val Leu Leu Ser Lys Pro Gln Asn Thr Val Ala Phe Asn 
        675                 680                 685             


Ile Lys Tyr Leu Lys Glu Lys Glu Ile Tyr Leu Arg Asn Ile Glu Lys 
    690                 695                 700                 


Lys Asn Ile Ile Pro Pro Phe Val Asn Arg Glu Arg Asn Lys Trp Cys 
705                 710                 715                 720 


Glu Arg Asp Cys Glu Tyr Tyr Arg Ile Leu Gly Glu Asn Leu Leu Asp 
                725                 730                 735     


Leu Pro Ile Glu Leu Pro Arg Gln Met Phe Tyr Lys Asp Ile Arg Ala 
            740                 745                 750         


Gln Leu Glu Pro Leu Met Pro Glu Ile Asp Phe Ser Gln Thr Asn Thr 
        755                 760                 765             


Thr Tyr Leu Ile Ala Glu Tyr Leu Lys Arg Val Arg Gly Asp Asp Phe 
    770                 775                 780                 


Gln Glu Phe Tyr Ser Trp Glu Arg Asn Tyr Arg Tyr Ile Asp Phe Leu 
785                 790                 795                 800 


Lys Cys Ile Arg Asp Asp Asn Gly Arg Ile Cys Ala Gln Tyr Thr Thr 
                805                 810                 815     


Thr Glu Glu Arg Glu Ser Leu Trp Glu Asp Ser Lys Asn Arg Thr Ala 
            820                 825                 830         


Glu Tyr Lys Arg Ser Glu Glu Gln Lys Asn Glu Lys Lys Asp Lys Asn 
        835                 840                 845             


Phe Glu Asp Ser Leu Glu Glu Arg Ile Ser Ser Ser His Ile Lys Phe 
    850                 855                 860                 


Gln Asn Thr Glu Lys His Ile Arg Arg Tyr Lys Val Gln Asp Ala Leu 
865                 870                 875                 880 


Leu Phe Met Ile Ala Glu Lys Gln Phe Gly Lys Tyr Leu Asp Asp Ile 
                885                 890                 895     


Lys Ala Lys Asn Phe Lys Leu Lys Asp Ile Met Pro Asp Thr Asp Lys 
            900                 905                 910         


Gly Ile Leu Ser Glu Thr Met Pro Ile Asp Phe Thr Phe Thr Lys Lys 
        915                 920                 925             


Asn Ile Lys Tyr Asn Ile His Ala Lys Asn Leu Lys Phe Lys Glu Tyr 
    930                 935                 940                 


Gly Asp Leu Phe Ile Leu Ala Asn Asp Lys Arg Leu Glu Ser Leu Trp 
945                 950                 955                 960 


Lys Ile Leu Ala Thr Asp Thr Val Asn Lys Glu Glu Ile Ser Glu Glu 
                965                 970                 975     


Phe Ala Lys Tyr Asp Phe Cys Arg Pro Asp Ile Thr Lys Leu Val Leu 
            980                 985                 990         


Asp Phe Glu Lys Asp Val Leu Glu  Lys Tyr Pro Glu Ile  Ile Glu Glu 
        995                 1000                 1005             


Ala Glu  Lys Glu Tyr Lys Lys  Phe Asp Phe Lys Phe  Ile Leu Asp 
    1010                 1015                 1020             


Trp Leu  Ile Asn Lys Lys Lys  Leu Asn Tyr Gly Ile  Arg Asn Lys 
    1025                 1030                 1035             


Leu Leu  Leu Ile Arg Asn Ala  Phe Asn His Asn Ser  Tyr Pro Asp 
    1040                 1045                 1050             


Lys Lys  Tyr Ala Glu Val Arg  Glu Leu Pro Glu Ile  Ala Thr Asn 
    1055                 1060                 1065             


Leu Lys  Lys Thr Phe Asp Glu  Asn Ala Lys Lys Tyr  Glu 
    1070                 1075                 1080     


<210>  1861
<211>  1214
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1861

Leu Ile Leu Ser Phe Ile Ile Phe Asn Phe Ile Val Ile Ile Asn Gln 
1               5                   10                  15      


His Thr Leu Asn Thr Tyr Thr Arg Lys Tyr Met Lys Asp Lys Ser Phe 
            20                  25                  30          


Ser Thr Ile Ser Ser Ala Ile Asn Glu Thr Ile Thr Thr Asp Asn Ile 
        35                  40                  45              


Lys Tyr Pro Glu Gln Leu Asn Leu Ile Leu Ser Lys Arg Leu Arg Pro 
    50                  55                  60                  


Lys Asn Glu Leu Gln Pro Leu Trp Ala Ala Tyr Phe Asn Met Ala Arg 
65                  70                  75                  80  


Tyr Asn Met Tyr Thr Thr Leu Val His Ile Ala Thr Ala Thr Gly Leu 
                85                  90                  95      


Ser Asp Glu Asp Asn Met Glu Asn Arg Met Asp Lys Met Arg Ile Leu 
            100                 105                 110         


Asn Glu Pro Val Glu Pro Glu Ile Glu His Arg Leu Arg Lys Leu Leu 
        115                 120                 125             


Cys Arg His Phe Pro Phe Ala Val Trp Met Ile Cys Asn Pro Ile Arg 
    130                 135                 140                 


Lys Lys Asp Ser Lys Glu Asp Ser Ala Asp Glu Asp Tyr Arg Val Ile 
145                 150                 155                 160 


Ser Val Lys Glu Leu Arg Asp Cys Leu Lys Thr Val Ser Tyr Thr Leu 
                165                 170                 175     


Asn Tyr Phe Arg Asn Tyr Tyr Ser His Thr Arg His Val Glu Thr Arg 
            180                 185                 190         


Ser Glu Asp Ile Ile Ala Ala Ser Arg Asn Ser Glu Lys Gln Thr Gly 
        195                 200                 205             


Ile Phe Leu Asn Lys Val Cys Thr Val Ala Thr Arg Arg Val Lys Ser 
    210                 215                 220                 


Arg Phe Ser Asp Lys Ser Asn Lys Gly Gln Ala Gly Met Ile Asp Asp 
225                 230                 235                 240 


Gln Ser Met Lys Phe Ile Thr Glu Gly Lys Val Lys Phe Arg Asn Asn 
                245                 250                 255     


Asn Gly Ile Lys Glu Thr Ile Tyr Asn Pro Asp His Phe Leu Tyr Pro 
            260                 265                 270         


Leu Phe Leu Asn Arg Ser Ser Ala Leu Arg Asp Gly Thr Asn Pro Glu 
        275                 280                 285             


Arg Leu Ser Thr Val Gly Lys Ile Gln Leu Ile Cys Leu Leu Leu Asp 
    290                 295                 300                 


Lys Lys Tyr Ile Thr Glu Phe Leu Asp Gln Ser Gly Phe Leu Ser Ala 
305                 310                 315                 320 


Phe Asn Asn Asn Ala Pro Ala Pro Lys Leu Ser Glu Arg Arg Leu Ile 
                325                 330                 335     


Leu Glu Val Leu Ser Asp Leu Arg Ile Arg Leu Pro Gln Arg Lys Ile 
            340                 345                 350         


Asp Ala Thr Cys Asn Asp Ile Gln Val Ala Leu Asp Met Leu Asn Glu 
        355                 360                 365             


Leu Lys Lys Cys Pro Lys Glu Leu Phe Glu Leu Leu Glu Ala Lys Asp 
    370                 375                 380                 


Lys Ala Thr Phe Ser Ile Leu Ser Ser Thr Gly Glu His Ile Leu Leu 
385                 390                 395                 400 


Arg Arg Ser Ser Asp Arg Phe Thr Gln Leu Ala Leu Gln Trp Phe Asp 
                405                 410                 415     


Val Asn Lys Ala Phe Ser Arg Ile Arg Phe His Met Asn Ala Gly Ile 
            420                 425                 430         


Phe Arg Tyr Leu Phe Asn Asp Ser Lys Thr Cys Ile Asp Gly Lys Thr 
        435                 440                 445             


Arg Leu Arg Val Leu Gln Glu Pro Leu Asn Cys Phe Gly Arg Ile Gln 
    450                 455                 460                 


Glu Val Glu Asp Ser Arg Glu Ser Asn Arg Asp Gly Asn Asp Gly Pro 
465                 470                 475                 480 


Trp Arg Gly Phe Glu Ile Lys Gly Phe Asp Glu Ala Ala Arg Asn Asp 
                485                 490                 495     


Val Asn Cys Leu Pro Tyr Ile Asn Asp Ser Arg Thr Arg Tyr Leu Ile 
            500                 505                 510         


Thr Glu Asp Asn Ile Gly Ile Arg Phe Ser Gly Asn Asp Glu Ala Cys 
        515                 520                 525             


Gly Asn Tyr Phe Pro Arg Ile Asp Glu Lys Asn Gly Lys Tyr Lys Val 
    530                 535                 540                 


Thr Cys Leu Pro Ala Gln Cys Met Ile Ser Ile Tyr Glu Leu Gln Ala 
545                 550                 555                 560 


Met Leu Phe Leu His Leu Leu Asn Pro Gly Asn Asp Gly Gly Ile Ala 
                565                 570                 575     


Pro Val Glu Lys Ile Ile Ile Asp Lys Val Glu Ser Tyr Arg Arg Phe 
            580                 585                 590         


Phe Ser Asp Ile Lys Asn Gly Leu Leu Thr Pro Ser Gly Leu Thr Glu 
        595                 600                 605             


Ser Ser Leu Asn Asp Lys Leu Thr Ser Thr Tyr Gly Ile Ser Leu Ser 
    610                 615                 620                 


Asp Ile Pro Asp Lys Met Lys Asp Tyr Leu Leu Lys Lys Asn Asn Lys 
625                 630                 635                 640 


Gly Arg Gly Phe Asn Ala Tyr Arg Asp Arg Leu Ile Glu Thr Leu Lys 
                645                 650                 655     


Glu Glu Thr Glu Tyr Arg Ile Lys Arg Leu Glu Glu Asn Leu Asn Ala 
            660                 665                 670         


Thr Asn Ser Asp Thr Asn Lys Pro Gly Lys Pro Gly Tyr Val Gln Ile 
        675                 680                 685             


Lys Pro Gly Ser Leu Ala Ser Phe Ile Ser Lys Asp Ile Val Phe Phe 
    690                 695                 700                 


Gln Glu Cys Asn Ala Asp Gln Lys Met Thr Gly Leu Asn Phe Ser Val 
705                 710                 715                 720 


Met Gln Gly Leu Ile Ala Thr Phe Gly Ser Gln Glu Gly Ala Thr Thr 
                725                 730                 735     


Asp Asp Leu Arg Met Ala Phe Arg Lys Ser Gly Leu Ile Ala Ala Asn 
            740                 745                 750         


Gly Ser Cys Gly Thr His Pro Phe Leu Ala Ile Ala Phe Asn Ala Gly 
        755                 760                 765             


Ala Lys Asn Thr Val Asp Leu Tyr Lys Glu Tyr Leu Asn Ala Arg Lys 
    770                 775                 780                 


Ser Tyr Leu Ser Gly Ile Ile Pro Asp Asn Ala Pro Phe Leu His Ala 
785                 790                 795                 800 


Asp Arg Ile Arg Trp Ala Val Asn Asp Asp Ala Tyr Tyr Lys Asp Tyr 
                805                 810                 815     


Ala Glu Arg Cys Leu Gln Arg Pro Val Ile Leu Pro Arg Arg Leu Phe 
            820                 825                 830         


Glu Ala Ser Ile Arg Glu Asn Leu Leu Ala Leu Asn Gly Glu Asn Ala 
        835                 840                 845             


Asn Ala Leu Lys Lys Val Ile Ile Gly Ala Gly Gly His Cys Asn Ser 
    850                 855                 860                 


Ala Phe Met Ile Asp Ser Tyr Phe Tyr Tyr Val Lys Asn Asp Ser Pro 
865                 870                 875                 880 


Gln Val Phe His Gly Ala Cys Glu Gly Asp Met Leu His Thr Tyr Gly 
                885                 890                 895     


His Arg Phe Phe Gln Val Val Arg Arg Asn Leu Lys Asn Ala Glu Ala 
            900                 905                 910         


Ile Leu Ser Lys Leu Lys Lys Asp Ser Asn Thr His Asn Thr Tyr Ile 
        915                 920                 925             


Gly Ala Leu Ser Asp Ala Ile Cys Trp Ala Lys Glu Asn Pro Ile Lys 
    930                 935                 940                 


Pro Thr Phe Ser Val Gly Arg Ser Arg Leu Asn Asn His Ser Glu Asn 
945                 950                 955                 960 


Glu Ile Ala Ala Met Ile Lys Arg Ala Phe Asn Glu Tyr Met Ala Thr 
                965                 970                 975     


Glu Lys Thr Leu Arg Arg Tyr Val Ile Gln Asp Glu Leu Leu Phe Leu 
            980                 985                 990         


Ala Ala Met Lys Thr Ile Lys Ser  Lys Leu Gly Val Pro  Asp Ser Glu 
        995                 1000                 1005             


Trp Lys  Leu Gly Ser Ile Gly  Ser Lys Ser Gly Ser  Ile Leu Asp 
    1010                 1015                 1020             


Lys Glu  Leu Pro Leu Ile Gln  Thr Pro Ala Lys Phe  Ser Asn Ile 
    1025                 1030                 1035             


Lys Arg  Arg Pro Asn Lys Thr  Ile Thr Lys Asp Leu  Val Glu Leu 
    1040                 1045                 1050             


Val Ile  Glu Gln His Asn Val  Ser Ile Lys Asp Tyr  Gly Glu Ile 
    1055                 1060                 1065             


Tyr Arg  Ile Leu Ala Asp Glu  Arg Leu Tyr Gly Leu  Leu Lys Tyr 
    1070                 1075                 1080             


His Lys  Asn Glu Thr Val Leu  Ala Ser Asp Leu Lys  Asn Glu Ile 
    1085                 1090                 1095             


Glu Lys  Tyr Asp Glu Lys Arg  Val Lys Val Phe Glu  Asp Ile Met 
    1100                 1105                 1110             


Asn Tyr  Glu Lys Lys Ile Thr  Asn Gly Val Thr Asp  Arg Gln Leu 
    1115                 1120                 1125             


Cys Glu  Ser Met Asp His Ala  Lys Asp Ile Asp Phe  Lys Val Met 
    1130                 1135                 1140             


Gln Thr  Phe Asp Thr Met Asn  Asp Asn Leu Thr Lys  Met Glu Leu 
    1145                 1150                 1155             


Arg Ser  Ile Arg Asn Ala Phe  Cys His Asn Ser Tyr  Pro Asp Val 
    1160                 1165                 1170             


Asn Ala  Phe Asp Asn Ser Ser  Gly Thr Thr Lys Arg  Ile Arg Ile 
    1175                 1180                 1185             


His Asn  Ala Asp Ile Pro Gly  Thr Ala Glu Lys Ile  Ser Glu Ile 
    1190                 1195                 1200             


Val Asn  Asp Ile Ser Ser Lys  Thr Glu Ala Lys 
    1205                 1210                 


<210>  1862
<211>  1081
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1862

Met Gln Ala Gln Ser Leu Phe Asp Glu Tyr Lys His Leu Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Val Met Ser Ile Met Asn Ile Ile Thr Val Leu Asn His Ile 
            20                  25                  30          


His Gln Ile Ala Gly Leu Lys Arg Asn Glu Leu Gly Asp Asp Asp Asn 
        35                  40                  45              


Ile Tyr Ser His Pro Val Leu Lys Tyr Ile Ala Pro Glu Asn Asn Ser 
    50                  55                  60                  


Thr Thr Leu Pro Glu Lys Arg Asp Leu Ile Lys Glu Leu Leu Leu Glu 
65                  70                  75                  80  


Tyr Leu Pro Phe Leu Glu Ala Met Lys Asp Cys Tyr Lys Glu Val Lys 
                85                  90                  95      


Val Glu Lys Asp Lys Arg Asn Asn Lys Tyr Val Lys Asp Lys Lys Gln 
            100                 105                 110         


Val Phe Ile Arg Asn Tyr Ser Asp Ile Tyr Cys Ile Tyr Trp Thr Leu 
        115                 120                 125             


Tyr Asn Ile Phe Ser Thr Leu Ile Asn Tyr Arg Asp Lys Ser Cys His 
    130                 135                 140                 


Tyr Arg Phe Ile Pro Ser Lys Asp Gln Glu Glu Tyr Ser Lys Arg Thr 
145                 150                 155                 160 


Glu Tyr Asp Thr Val Arg Ile Ile Asn Lys Tyr Tyr Thr Tyr Ala Leu 
                165                 170                 175     


Arg Lys Thr Lys Glu Lys Tyr Gly Tyr Thr Thr Glu Gln Leu Ser Phe 
            180                 185                 190         


Ile Gln Asn Asn Arg Tyr Thr Asp Asp Lys Lys Val Asn Phe Asn Phe 
        195                 200                 205             


Phe Leu Ser Met Gln Ser Ser Asn Asn Asn Leu Ser His Val Gly Val 
    210                 215                 220                 


Ala Gln Leu Ile Cys Leu Phe Leu Gln Lys Lys Asp Val Asp Asn Phe 
225                 230                 235                 240 


Leu Glu Asn Leu Pro Ile Tyr Asp Asn Arg Tyr Cys Leu Gly Ile Asp 
                245                 250                 255     


Glu His Met Ile Ile Lys Arg Ser Leu Ala Leu His Ser Ile Lys Leu 
            260                 265                 270         


Pro Lys Glu Arg Leu Asn Ser Glu Lys Lys Asp Met Ala Ile Ala Met 
        275                 280                 285             


Asp Met Leu Asn Glu Leu Lys Arg Cys Pro Lys Glu Leu Phe Asn Thr 
    290                 295                 300                 


Leu Pro Phe Asp Lys Gln Glu Arg Phe Arg Ile Ile Ser Ser Asp His 
305                 310                 315                 320 


Lys Glu Val Leu Leu Met Arg Ser Thr Asp Arg Phe Val Pro Leu Ile 
                325                 330                 335     


Leu Gln Tyr Ile Asp Cys Asn Lys Lys Phe Lys Asp Ile Arg Phe His 
            340                 345                 350         


Val Asn Met Gly Lys Leu Arg Tyr Leu Phe Ser Pro Asn Lys Leu Cys 
        355                 360                 365             


Ile Asp Asn Gln Glu Arg Val Arg Met Leu Glu His Leu Leu Asn Gly 
    370                 375                 380                 


Tyr Gly Arg Ile Asp Glu Val Glu Tyr Leu Arg Lys Ala Pro Asn Gly 
385                 390                 395                 400 


Thr Phe Gly Asn Thr Asn Ile Pro Ile Lys Gly Phe Gly Glu Ile Glu 
                405                 410                 415     


Arg Asp Ser Ala Asp Ser Asn Asn Tyr Pro Tyr Ile Val Asp Thr His 
            420                 425                 430         


Thr His Tyr Ile Leu Asn Asn Asn Lys Val Glu Phe Cys Phe Cys Glu 
        435                 440                 445             


Asp Ser Lys Asn Lys Asn Val Phe Pro Thr Ile Glu Lys Glu Ile Asn 
    450                 455                 460                 


Gly Lys Trp Tyr Val Glu Lys Thr Ala Pro His Cys Arg Ile Ser Phe 
465                 470                 475                 480 


Phe Glu Ile Pro Ala Met Ala Phe His Met Phe Leu Cys Gly Ser Glu 
                485                 490                 495     


Lys Thr Glu Lys Leu Ile Lys Asp Val Tyr Asn Asn Tyr Ile Ser Leu 
            500                 505                 510         


Phe Asn Ala Leu Lys Asn Gly Ala Leu Thr Glu Glu Asn Tyr Lys Asp 
        515                 520                 525             


Phe Asn Ile Pro Glu Cys Asp Met Pro Lys Lys Ile Leu Asp Phe Leu 
    530                 535                 540                 


Lys Gly Lys Ala Glu Gly Lys Ser Ile Asp Gly Tyr Val Lys Asn Ile 
545                 550                 555                 560 


Leu Lys Lys Glu Leu Lys Asp Thr Arg Lys Arg Ile Glu Gln Ala Pro 
                565                 570                 575     


Ser Glu Lys Asp Gln Met Pro Ser Lys Arg Asn Lys Ile Gly Thr Lys 
            580                 585                 590         


Ser Tyr Lys Arg Val Leu Thr Gly Lys Leu Ala Asp Phe Leu Ala Lys 
        595                 600                 605             


Asp Ile Val Lys Tyr Gln Pro Thr Leu Cys Ala Gly Asp Asp Tyr Gly 
    610                 615                 620                 


Ile Asp Arg Met Thr Gly Met Asn Tyr Arg Ile Met Gln Ala Thr Ile 
625                 630                 635                 640 


Ala Thr Tyr Asn Asp Asp Asp Asp Phe Asp Thr Phe Tyr Asn Val Phe 
                645                 650                 655     


Lys Met Ala Gly Leu Val Asp Gly Asp Glu Arg Lys Asn His Pro Phe 
            660                 665                 670         


Leu Lys Lys Val Leu Leu Ser Lys Pro Gln Asn Thr Val Ala Phe Asn 
        675                 680                 685             


Ile Lys Tyr Leu Lys Glu Lys Glu Ile Tyr Leu Arg Asn Ile Glu Lys 
    690                 695                 700                 


Lys Asn Ile Ile Pro Pro Phe Val Asn Arg Glu Arg Asn Lys Trp Cys 
705                 710                 715                 720 


Glu Arg Asp Cys Glu Tyr Tyr Arg Ile Leu Gly Glu Asn Leu Leu Asp 
                725                 730                 735     


Leu Pro Ile Glu Leu Pro Arg Gln Met Phe Tyr Lys Asp Ile Arg Ala 
            740                 745                 750         


Gln Leu Glu Pro Leu Met Pro Glu Ile Asp Phe Ser Gln Thr Asn Thr 
        755                 760                 765             


Thr Tyr Leu Ile Ala Glu Tyr Leu Lys Arg Val Arg Gly Asp Asp Phe 
    770                 775                 780                 


Gln Glu Phe Tyr Ser Trp Glu Arg Asn Tyr Arg Tyr Ile Asp Phe Leu 
785                 790                 795                 800 


Lys Cys Ile Arg Asp Asp Asn Gly Arg Ile Cys Ala Gln Tyr Thr Thr 
                805                 810                 815     


Thr Glu Glu Arg Glu Ser Leu Trp Glu Asp Ser Lys Asn Arg Thr Ala 
            820                 825                 830         


Glu Tyr Lys Arg Ser Glu Glu Gln Lys Asn Glu Lys Lys Asp Lys Asn 
        835                 840                 845             


Phe Glu Asp Ser Leu Glu Glu Arg Ile Ser Ser Ser His Ile Lys Phe 
    850                 855                 860                 


Gln Asn Thr Glu Lys His Ile Arg Arg Tyr Lys Val Gln Asp Ala Leu 
865                 870                 875                 880 


Leu Phe Met Ile Ala Glu Lys Gln Phe Gly Lys Tyr Leu Asp Asp Ile 
                885                 890                 895     


Lys Ala Lys Asn Phe Lys Leu Lys Asp Ile Met Pro Asp Thr Asp Lys 
            900                 905                 910         


Gly Ile Leu Ser Glu Thr Met Pro Ile Asp Phe Thr Phe Thr Lys Lys 
        915                 920                 925             


Asn Ile Lys Tyr Asn Ile His Ala Lys Asn Leu Lys Phe Lys Glu Tyr 
    930                 935                 940                 


Gly Asp Leu Phe Ile Leu Ala Asn Asp Lys Arg Leu Glu Ser Leu Trp 
945                 950                 955                 960 


Lys Ile Leu Ala Thr Asp Thr Val Asn Lys Glu Glu Ile Ser Glu Glu 
                965                 970                 975     


Phe Ala Lys Tyr Asp Phe Cys Arg Pro Asp Ile Thr Lys Leu Val Leu 
            980                 985                 990         


Asp Phe Glu Lys Asp Val Leu Glu  Lys Tyr Pro Glu Ile  Ile Glu Glu 
        995                 1000                 1005             


Ala Glu  Lys Glu Tyr Lys Lys  Phe Asp Phe Lys Phe  Ile Leu Asp 
    1010                 1015                 1020             


Trp Leu  Ile Asn Lys Lys Lys  Leu Asn Tyr Gly Ile  Arg Asn Lys 
    1025                 1030                 1035             


Leu Leu  Leu Ile Arg Asn Ala  Phe Asn His Asn Ser  Tyr Pro Asp 
    1040                 1045                 1050             


Lys Lys  Tyr Ala Glu Val Arg  Glu Leu Pro Glu Ile  Ala Thr Asn 
    1055                 1060                 1065             


Leu Lys  Lys Thr Phe Asp Glu  Asn Ala Lys Lys Tyr  Glu 
    1070                 1075                 1080     


<210>  1863
<211>  1214
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1863

Leu Ile Leu Ser Phe Ile Ile Phe Asn Phe Ile Val Ile Ile Asn Gln 
1               5                   10                  15      


His Thr Leu Asn Thr Tyr Thr Arg Lys Tyr Met Lys Asp Lys Ser Phe 
            20                  25                  30          


Ser Thr Ile Ser Ser Ala Ile Asn Glu Thr Ile Thr Thr Asp Asn Ile 
        35                  40                  45              


Lys Tyr Pro Glu Gln Leu Asn Leu Ile Leu Ser Lys Arg Leu Arg Pro 
    50                  55                  60                  


Lys Asn Glu Leu Gln Pro Leu Trp Ala Ala Tyr Phe Asn Met Ala Arg 
65                  70                  75                  80  


Tyr Asn Met Tyr Thr Thr Leu Val His Ile Ala Thr Ala Thr Gly Leu 
                85                  90                  95      


Ser Asp Glu Asp Asn Met Glu Asn Arg Met Asp Lys Met Arg Ile Leu 
            100                 105                 110         


Asn Glu Pro Val Glu Pro Glu Ile Glu His Arg Leu Arg Lys Leu Leu 
        115                 120                 125             


Cys Arg His Phe Pro Phe Ala Val Trp Met Ile Cys Asn Pro Ile Arg 
    130                 135                 140                 


Lys Lys Asp Ser Lys Glu Asp Ser Ala Asp Glu Asp Tyr Arg Val Ile 
145                 150                 155                 160 


Ser Val Lys Glu Leu Arg Asp Cys Leu Lys Thr Val Ser Tyr Thr Leu 
                165                 170                 175     


Asn Tyr Phe Arg Asn Tyr Tyr Ser His Thr Arg His Val Glu Thr Arg 
            180                 185                 190         


Ser Glu Asp Ile Ile Ala Ala Ser Arg Asn Ser Glu Lys Gln Thr Gly 
        195                 200                 205             


Ile Phe Leu Asn Lys Val Cys Thr Val Ala Thr Arg Arg Val Lys Ser 
    210                 215                 220                 


Arg Phe Ser Asp Lys Ser Asn Lys Gly Gln Ala Gly Met Ile Asp Asp 
225                 230                 235                 240 


Gln Ser Met Lys Phe Ile Thr Glu Gly Lys Val Lys Phe Arg Asn Asn 
                245                 250                 255     


Asn Gly Ile Lys Glu Thr Ile Tyr Asn Pro Asp His Phe Leu Tyr Pro 
            260                 265                 270         


Leu Phe Leu Asn Arg Ser Ser Ala Leu Arg Asp Gly Thr Asn Pro Glu 
        275                 280                 285             


Arg Leu Ser Thr Val Gly Lys Ile Gln Leu Ile Cys Leu Leu Leu Asp 
    290                 295                 300                 


Lys Lys Tyr Ile Thr Glu Phe Leu Asp Gln Ser Gly Phe Leu Ser Ala 
305                 310                 315                 320 


Phe Asn Asn Asn Ala Pro Ala Pro Lys Leu Ser Glu Arg Arg Leu Ile 
                325                 330                 335     


Leu Glu Val Leu Ser Asp Leu Arg Ile Arg Leu Pro Gln Arg Lys Ile 
            340                 345                 350         


Asp Ala Thr Cys Asn Asp Ile Gln Val Ala Leu Asp Met Leu Asn Glu 
        355                 360                 365             


Leu Lys Lys Cys Pro Lys Glu Leu Phe Glu Leu Leu Glu Ala Lys Asp 
    370                 375                 380                 


Lys Ala Thr Phe Ser Ile Leu Ser Ser Thr Gly Glu His Ile Leu Leu 
385                 390                 395                 400 


Arg Arg Ser Ser Asp Arg Phe Thr Gln Leu Ala Leu Gln Trp Phe Asp 
                405                 410                 415     


Val Asn Lys Ala Phe Ser Arg Ile Arg Phe His Met Asn Ala Gly Ile 
            420                 425                 430         


Phe Arg Tyr Leu Phe Asn Asp Ser Lys Thr Cys Ile Asp Gly Lys Thr 
        435                 440                 445             


Arg Leu Arg Val Leu Gln Glu Pro Leu Asn Cys Phe Gly Arg Ile Gln 
    450                 455                 460                 


Glu Val Glu Asp Ser Arg Glu Ser Asn Arg Asp Gly Asn Asp Gly Pro 
465                 470                 475                 480 


Trp Arg Gly Phe Glu Ile Lys Gly Phe Asp Glu Ala Ala Arg Asn Asp 
                485                 490                 495     


Val Asn Cys Leu Pro Tyr Ile Asn Asp Ser Arg Thr Arg Tyr Leu Ile 
            500                 505                 510         


Thr Glu Asp Asn Ile Gly Ile Arg Phe Ser Gly Asn Asp Glu Ala Cys 
        515                 520                 525             


Gly Asn Tyr Phe Pro Arg Ile Asp Glu Lys Asn Gly Lys Tyr Lys Val 
    530                 535                 540                 


Thr Cys Leu Pro Ala Gln Cys Met Ile Ser Ile Tyr Glu Leu Gln Ala 
545                 550                 555                 560 


Met Leu Phe Leu His Leu Leu Asn Pro Gly Asn Asp Gly Gly Ile Ala 
                565                 570                 575     


Pro Val Glu Lys Ile Ile Ile Asp Lys Val Glu Ser Tyr Arg Arg Phe 
            580                 585                 590         


Phe Ser Asp Ile Lys Asn Gly Leu Leu Thr Pro Ser Gly Leu Thr Glu 
        595                 600                 605             


Ser Ser Leu Asn Asp Lys Leu Thr Ser Thr Tyr Gly Ile Ser Leu Ser 
    610                 615                 620                 


Asp Ile Pro Asp Lys Met Lys Asp Tyr Leu Leu Lys Lys Asn Asn Lys 
625                 630                 635                 640 


Gly Arg Gly Phe Asn Ala Tyr Arg Asp Arg Leu Ile Glu Thr Leu Lys 
                645                 650                 655     


Glu Glu Thr Glu Tyr Arg Ile Lys Arg Leu Glu Glu Asn Leu Asn Ala 
            660                 665                 670         


Thr Asn Ser Asp Thr Asn Lys Pro Gly Lys Pro Gly Tyr Val Gln Ile 
        675                 680                 685             


Lys Pro Gly Ser Leu Ala Ser Phe Ile Ser Lys Asp Ile Val Phe Phe 
    690                 695                 700                 


Gln Glu Cys Asn Ala Asp Gln Lys Met Thr Gly Leu Asn Phe Ser Val 
705                 710                 715                 720 


Met Gln Gly Leu Ile Ala Thr Phe Gly Ser Gln Glu Gly Ala Thr Thr 
                725                 730                 735     


Asp Asp Leu Arg Met Ala Phe Arg Lys Ser Gly Leu Ile Ala Ala Asn 
            740                 745                 750         


Gly Ser Cys Gly Thr His Pro Phe Leu Ala Ile Ala Phe Asn Ala Gly 
        755                 760                 765             


Ala Lys Asn Thr Val Asp Leu Tyr Lys Glu Tyr Leu Asn Ala Arg Lys 
    770                 775                 780                 


Ser Tyr Leu Ser Gly Ile Ile Pro Asp Asn Ala Pro Phe Leu His Ala 
785                 790                 795                 800 


Asp Arg Ile Arg Trp Ala Val Asn Asp Asp Ala Tyr Tyr Lys Asp Tyr 
                805                 810                 815     


Ala Glu Arg Cys Leu Gln Arg Pro Val Ile Leu Pro Arg Arg Leu Phe 
            820                 825                 830         


Glu Ala Ser Ile Arg Glu Asn Leu Leu Ala Leu Asn Gly Glu Asn Ala 
        835                 840                 845             


Asn Ala Leu Lys Lys Val Ile Ile Gly Ala Gly Gly His Cys Asn Ser 
    850                 855                 860                 


Ala Phe Met Ile Asp Ser Tyr Phe Tyr Tyr Val Lys Asn Asp Ser Pro 
865                 870                 875                 880 


Gln Val Phe His Gly Ala Cys Glu Gly Asp Met Leu His Thr Tyr Gly 
                885                 890                 895     


His Arg Phe Phe Gln Val Val Arg Arg Asn Leu Lys Asn Ala Glu Ala 
            900                 905                 910         


Ile Leu Ser Lys Leu Lys Lys Asp Ser Asn Thr His Asn Thr Tyr Ile 
        915                 920                 925             


Gly Ala Leu Ser Asp Ala Ile Cys Trp Ala Lys Glu Asn Pro Ile Lys 
    930                 935                 940                 


Pro Thr Phe Ser Val Gly Arg Ser Arg Leu Asn Asn His Ser Glu Asn 
945                 950                 955                 960 


Glu Ile Ala Ala Met Ile Lys Arg Ala Phe Asn Glu Tyr Met Ala Thr 
                965                 970                 975     


Glu Lys Thr Leu Arg Arg Tyr Val Ile Gln Asp Glu Leu Leu Phe Leu 
            980                 985                 990         


Ala Ala Met Lys Thr Ile Lys Ser  Lys Leu Gly Val Pro  Asp Ser Glu 
        995                 1000                 1005             


Trp Lys  Leu Gly Ser Ile Gly  Ser Lys Ser Gly Ser  Ile Leu Asp 
    1010                 1015                 1020             


Lys Glu  Leu Pro Leu Ile Gln  Thr Pro Ala Lys Phe  Ser Asn Ile 
    1025                 1030                 1035             


Lys Arg  Arg Pro Asn Lys Thr  Ile Thr Lys Asp Leu  Val Glu Leu 
    1040                 1045                 1050             


Val Ile  Glu Gln His Asn Val  Ser Ile Lys Asp Tyr  Gly Glu Ile 
    1055                 1060                 1065             


Tyr Arg  Ile Leu Ala Asp Glu  Arg Leu Tyr Gly Leu  Leu Lys Tyr 
    1070                 1075                 1080             


His Lys  Asn Glu Thr Val Leu  Ala Ser Asp Leu Lys  Asn Glu Ile 
    1085                 1090                 1095             


Glu Lys  Tyr Asp Glu Lys Arg  Val Lys Val Phe Glu  Asp Ile Met 
    1100                 1105                 1110             


Asn Tyr  Glu Lys Lys Ile Thr  Asn Gly Val Thr Asp  Arg Gln Leu 
    1115                 1120                 1125             


Cys Glu  Ser Met Asp His Ala  Lys Asp Ile Asp Phe  Lys Val Met 
    1130                 1135                 1140             


Gln Thr  Phe Asp Thr Met Asn  Asp Asn Leu Thr Lys  Met Glu Leu 
    1145                 1150                 1155             


Arg Ser  Ile Arg Asn Ala Phe  Cys His Asn Ser Tyr  Pro Asp Val 
    1160                 1165                 1170             


Asn Ala  Phe Asp Asn Ser Ser  Gly Thr Thr Lys Arg  Ile Arg Ile 
    1175                 1180                 1185             


His Asn  Ala Asp Ile Pro Gly  Thr Ala Glu Lys Ile  Ser Glu Ile 
    1190                 1195                 1200             


Val Asn  Asp Ile Ser Ser Lys  Thr Glu Ala Lys 
    1205                 1210                 


<210>  1864
<211>  1088
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1864

Met Lys Ile Pro Asp Leu Ile Asn Asn Tyr Lys Glu Gln Phe Gly Thr 
1               5                   10                  15      


Tyr Ala Val Met Ala Leu Met Asn Ala Gln Thr Val Leu Asp His Ile 
            20                  25                  30          


Gln Lys Leu Ala Cys Ile Gly Asn Ser Glu Ser Tyr Lys Glu Asp Leu 
        35                  40                  45              


Trp Lys His Pro Val Met Leu His Ile Lys Asn Ala Ala Tyr Glu Thr 
    50                  55                  60                  


Asp Asn Asn Pro Glu Thr Thr Leu Phe Val Met Glu Lys Leu Gln Phe 
65                  70                  75                  80  


Tyr Phe Pro Phe Leu Lys Ile Met Ala Glu Arg Gln Arg Glu Tyr Ser 
                85                  90                  95      


Asn Lys Lys Tyr Asn Glu Asn Arg Leu Ala Val Asn Ser Arg Asp Leu 
            100                 105                 110         


Phe Phe Val Leu Asp Lys Val Phe Arg Val Leu Lys Asn Tyr Arg Asn 
        115                 120                 125             


Thr Thr Ala His Phe Met Thr Lys Ser Leu Ser Glu Asn Glu Glu Tyr 
    130                 135                 140                 


Leu Phe Leu Lys Asn Glu Gln Pro Leu Ala Asn Met Val Asn Glu Tyr 
145                 150                 155                 160 


Tyr Thr Val Ala Leu Arg Asp Met Lys Asp Arg Tyr Ser Tyr Ser Thr 
                165                 170                 175     


Glu Asp Leu Ala Phe Ile Gln Asp Asn Arg Tyr Lys Gln Thr Arg Gly 
            180                 185                 190         


Asp Asp Gly Lys Arg Lys Ala Thr Val Asn Leu Asp Phe Phe Leu Ser 
        195                 200                 205             


Leu Gln Ser His Asn Gly Asp Pro Ala Lys Lys Leu His Leu Ser Gly 
    210                 215                 220                 


Val Gly Val Ala Leu Leu Ile Cys Leu Phe Leu Glu Lys Gln Tyr Val 
225                 230                 235                 240 


Asn Leu Phe Ile Ser Lys Leu Ser Ile Phe Ser Thr Tyr Lys Pro Asn 
                245                 250                 255     


Ser Glu Gln His Arg Ile Ile Cys Arg Ser Met Gly Ile His Ser Ile 
            260                 265                 270         


Lys Leu Pro Lys Asp Arg Ile His Ser Leu Lys Asp Gly Met Ser Val 
        275                 280                 285             


Ala Met Asp Met Leu Asn Glu Thr Lys Arg Cys Pro Lys Glu Leu Phe 
    290                 295                 300                 


Asp Thr Leu Ser Ala Asp Lys Gln Ala Arg Phe Arg Thr Ile Ser Asp 
305                 310                 315                 320 


Asp His Asn Glu Val Leu Leu Met Arg Ser Ser Asp Arg Phe Ala Gln 
                325                 330                 335     


Leu Leu Leu Gln Tyr Ile Asp Tyr Asn Lys Leu Phe Lys Gly Ile Arg 
            340                 345                 350         


Phe His Val Asn Met Gly Lys Leu Arg Tyr Leu Phe Asn Ala Ala Lys 
        355                 360                 365             


Asn Cys Ile Asp Gly Gln Thr Arg Val Arg Val Ile Glu His Gln Leu 
    370                 375                 380                 


Asn Gly Tyr Gly Arg Ile Asp Glu Ile Glu Ala Glu Arg Lys Ser Glu 
385                 390                 395                 400 


Asp Gly Lys Phe Ala Asn Ser Gly Ile Ser Ile Arg Asp Phe Glu Asn 
                405                 410                 415     


Val Arg Arg Asp Asp Gly Asn Pro Glu Asn Tyr Pro Tyr Val Val Asp 
            420                 425                 430         


Thr Tyr Ser His Tyr Ile Leu Glu Asn Asn Lys Val Glu Met Gln Phe 
        435                 440                 445             


Thr Asp Ser Cys Ile Leu Pro Phe Ile Glu Glu Tyr Gly Gly Lys Trp 
    450                 455                 460                 


Tyr Val Ala Lys Asp Val Pro Ala Cys Arg Ile Ser Thr Leu Glu Leu 
465                 470                 475                 480 


Pro Ala Leu Ala Phe His Met Leu Leu Leu Gly Ser Lys Lys Thr Glu 
                485                 490                 495     


Glu Arg Ile Lys Glu Val Tyr Gly Lys Tyr Met Lys Leu Phe Glu Ala 
            500                 505                 510         


Met Ser Asn Asp Ala Val Thr Lys Glu Asn Ile Glu Ser Phe Gly Ile 
        515                 520                 525             


Ala Leu Trp Asn Leu Pro Gln Lys Ala Ile Asp Ala Ile Asn Gly Cys 
    530                 535                 540                 


Ala His Ala Lys Asn Val Asn Ala Phe Ile Lys Asn Thr Val Glu Glu 
545                 550                 555                 560 


Met Leu Ala Asp Thr Glu Lys Arg Leu Glu Arg Leu Lys Glu Asp Arg 
                565                 570                 575     


Lys Gly Ile Ser Ser His Asp Asn Lys Met Gly Lys Pro Asn Phe Arg 
            580                 585                 590         


Gln Ile Ser Thr Gly Arg Leu Ala Asp Phe Leu Ala Lys Asp Ile Val 
        595                 600                 605             


Lys Leu Gln Pro Ala Thr Thr Glu Asp Gly Ser Asp Lys Met Thr Gly 
    610                 615                 620                 


Leu Asn Tyr Arg Val Met Gln Ala Ala Ile Ala Thr Tyr Asn Ser Asn 
625                 630                 635                 640 


Gly Asn Pro Glu Ala Glu Gln Gln Phe Arg Gly Met Phe Glu Lys Ala 
                645                 650                 655     


Arg Leu Ile Gly Lys Ser Pro Asn Ala His Pro Phe Leu Tyr Lys Val 
            660                 665                 670         


Phe Ala Ser Ala Leu Pro Lys Asn Thr Ile Glu Phe Tyr Asp Lys Tyr 
        675                 680                 685             


Leu Arg Glu Arg Lys Arg Tyr Leu Ser Asn Leu Thr Lys Asp Ile Glu 
    690                 695                 700                 


Ser Gly Lys Thr Ala Ser Val Pro Phe Val Asn Arg Asn Gln Asn Lys 
705                 710                 715                 720 


Trp Lys Lys Pro Asn Gln Glu Tyr Leu Gly Gln Thr Tyr Gly Asn Ser 
                725                 730                 735     


Gln Asn Leu Ala Ile Glu Leu Pro Arg Gln Met Phe Asp Ala Asp Ile 
            740                 745                 750         


Lys Ala Phe Leu Lys Gly Leu Pro Glu Met Lys Asp Val Asp Phe Asp 
        755                 760                 765             


Asn Ala Asn Val Thr Phe Leu Ile Gly Glu Tyr Met Lys Arg Val Leu 
    770                 775                 780                 


Ala Asp Asp Phe Gln Asn Phe Tyr Ala Trp Lys Arg Asn Tyr Arg Tyr 
785                 790                 795                 800 


Met Asp Met Leu Met Gly Glu Thr Asp Ser Lys Asp Gly Leu Arg His 
                805                 810                 815     


Met Phe Thr Ser Val Glu Glu Arg Glu Lys Leu Trp Arg Glu Arg Glu 
            820                 825                 830         


Gly Arg Thr Ser Ser Tyr Arg Lys Trp Ala Ala Arg Lys Asn Gln Gly 
        835                 840                 845             


Cys Gly Tyr Ser Lys Arg Leu Pro Asp Asn Val Leu Asp Glu Ile Leu 
    850                 855                 860                 


Ala Lys Arg Leu Ser Gly Ser Arg Asn Asp Tyr Gln Lys Cys Glu Lys 
865                 870                 875                 880 


Ala Ile Arg Arg Gln Lys Val Gln Asp Ala Met Leu Phe Met Leu Ala 
                885                 890                 895     


Lys Lys Ala Phe Thr Gln His Ala Asp Phe Glu Gly Lys Asp Phe Lys 
            900                 905                 910         


Leu Lys Asn Ile Met Pro Asp Ala Asp Lys Gly Ile Leu Ser Glu Thr 
        915                 920                 925             


Met Pro Met Thr Phe Thr Phe Glu Lys Gly Gly Lys Gln Tyr Thr Ile 
    930                 935                 940                 


Glu Ser Gly Gly Met Lys Leu Lys Asn Tyr Gly Asp Phe His Ala Leu 
945                 950                 955                 960 


Ala Asn Asp Arg Arg Ile Gly Cys Leu Met Lys Leu Ile Gly Thr Asn 
                965                 970                 975     


Thr Ala Gln Lys Glu Asp Leu Ile Ser Glu Phe Asn Lys Tyr Asp Gln 
            980                 985                 990         


Cys Arg Pro Gln Val Val Lys Leu  Val Leu Asp Leu Glu  Lys Trp Ala 
        995                 1000                 1005             


Phe Ala  Lys Tyr Pro Glu Leu  Gly Ala Ser Glu Glu  Met Ser Tyr 
    1010                 1015                 1020             


Val Ser  Phe Asp Lys Ile Leu  Asn Lys Leu Thr Gln  His Arg Asn 
    1025                 1030                 1035             


Leu Gly  Asn Arg Gln Ser Asn  Ile Leu Arg Lys Ile  Arg Asn Ala 
    1040                 1045                 1050             


Phe Asp  His Asn Ser Tyr Pro  Glu Ser Gly Ile Val  Glu Ile Thr 
    1055                 1060                 1065             


Thr Leu  Pro Glu Ile Ala Gln  Asn Met Lys Asp Met  Phe Gly Arg 
    1070                 1075                 1080             


Tyr Ala  Ile Val Lys 
    1085             


<210>  1865
<211>  1139
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1865

Met Glu Asn Asp Lys Arg Leu Glu Glu Ser Ala Cys Tyr Thr Leu Asn 
1               5                   10                  15      


Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val 
            20                  25                  30          


Tyr Ile Thr Val Asn His Ile Asn Lys Thr Leu Glu Leu Lys Asn Lys 
        35                  40                  45              


Lys Asn Gln Glu Ile Ile Ile Asp Asn Asp Gln Asp Ile Leu Ala Ile 
    50                  55                  60                  


Lys Thr His Trp Ala Lys Val Asn Gly Asp Leu Asn Lys Thr Asp Arg 
65                  70                  75                  80  


Leu Arg Glu Leu Met Ile Lys His Phe Pro Phe Leu Glu Ala Ala Ile 
                85                  90                  95      


Tyr Ser Asn Asn Lys Glu Asp Lys Glu Glu Val Lys Glu Glu Lys Gln 
            100                 105                 110         


Ala Lys Ala Gln Ser Phe Lys Ser Leu Lys Asp Cys Leu Phe Leu Phe 
        115                 120                 125             


Leu Glu Lys Leu Gln Glu Ala Arg Asn Tyr Tyr Ser His Tyr Lys Tyr 
    130                 135                 140                 


Ser Glu Ser Ser Lys Glu Pro Glu Phe Glu Glu Gly Leu Leu Glu Lys 
145                 150                 155                 160 


Met Tyr Asn Thr Phe Asp Ala Ser Ile Arg Leu Val Lys Glu Asp Tyr 
                165                 170                 175     


Gln Tyr Asn Lys Asp Ile Asp Pro Glu Lys Asp Phe Lys His Leu Glu 
            180                 185                 190         


Arg Lys Glu Asp Phe Asn Tyr Leu Phe Thr Asp Lys Asp Asn Lys Gly 
        195                 200                 205             


Lys Ile Thr Lys Asn Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Glu 
    210                 215                 220                 


Lys Lys Asp Ala Ile Trp Met Gln Gln Lys Phe Arg Gly Phe Lys Asp 
225                 230                 235                 240 


Asn Arg Gly Asn Lys Glu Lys Met Thr His Glu Val Phe Cys Arg Ser 
                245                 250                 255     


Arg Met Leu Leu Pro Lys Ile Arg Leu Glu Ser Thr Gln Thr Gln Asp 
            260                 265                 270         


Trp Ile Leu Leu Asp Met Leu Asn Glu Leu Ile Arg Cys Pro Lys Ser 
        275                 280                 285             


Leu Tyr Glu Arg Leu Gln Gly Ala Tyr Arg Glu Lys Phe Lys Val Pro 
    290                 295                 300                 


Phe Asp Ser Ile Asp Glu Asp Tyr Asp Ala Glu Gln Glu Pro Phe Arg 
305                 310                 315                 320 


Asn Thr Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Ala Leu Arg 
                325                 330                 335     


Tyr Phe Asp Tyr Asn Glu Ile Phe Lys Asn Leu Arg Phe Gln Ile Asp 
            340                 345                 350         


Leu Gly Thr Tyr His Phe Ser Ile Tyr Lys Lys Leu Ile Gly Gly Lys 
        355                 360                 365             


Lys Glu Asp Arg His Leu Thr His Lys Leu Tyr Gly Phe Glu Arg Ile 
    370                 375                 380                 


Gln Glu Phe Thr Lys Gln Asn Arg Pro Asp Lys Trp Gln Ala Ile Ile 
385                 390                 395                 400 


Lys Asp Leu Asp Thr Tyr Glu Thr Ser Asn Glu Arg Tyr Ile Ser Glu 
                405                 410                 415     


Thr Thr Pro His Tyr His Leu Glu Asn Gln Lys Ile Gly Ile Arg Phe 
            420                 425                 430         


Arg Asn Asp Asn Asn Asp Ile Trp Pro Ser Leu Lys Thr Asn Gly Glu 
        435                 440                 445             


Lys Asn Glu Lys Ser Lys Tyr Asn Leu Asp Lys Pro Tyr Gln Ala Glu 
    450                 455                 460                 


Ala Phe Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu 
465                 470                 475                 480 


Leu Leu Lys Met Glu Asn Thr Asp Asn Asp Lys Glu Asp Asn Glu Val 
                485                 490                 495     


Gly Thr Lys Lys Lys Gly Asn Lys Asn Asn Lys Gln Glu Lys His Lys 
            500                 505                 510         


Ile Glu Glu Ile Ile Glu Asn Lys Ile Lys Asp Ile Tyr Ala Leu Tyr 
        515                 520                 525             


Asp Ala Phe Ala Asn Gly Glu Ile Asn Ser Ile Asp Glu Leu Ala Glu 
    530                 535                 540                 


Gln Arg Glu Gly Lys Asp Ile Glu Ile Gly His Leu Pro Lys Gln Leu 
545                 550                 555                 560 


Ile Val Ile Leu Lys Asn Lys Ser Lys Asp Met Ala Glu Lys Ala Asn 
                565                 570                 575     


Arg Lys Gln Lys Glu Met Ile Lys Asp Thr Lys Lys Arg Leu Ala Thr 
            580                 585                 590         


Leu Asp Lys Gln Val Lys Gly Glu Ile Glu Asp Gly Gly Arg Asn Ile 
        595                 600                 605             


Arg Leu Leu Lys Ser Gly Glu Ile Ala Arg Trp Leu Val Asn Asp Met 
    610                 615                 620                 


Met Arg Phe Gln Pro Val Gln Lys Asp Asn Glu Gly Lys Pro Leu Asn 
625                 630                 635                 640 


Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln Met Leu Gln Arg Ser Leu 
                645                 650                 655     


Ala Leu Tyr Asn Lys Glu Glu Lys Pro Thr Arg Tyr Phe Arg Gln Val 
            660                 665                 670         


Asn Leu Ile Lys Ser Ser Asn Pro His Pro Phe Leu Glu Asp Thr Lys 
        675                 680                 685             


Trp Glu Glu Cys Tyr Asn Ile Leu Ser Phe Tyr Arg Asn Tyr Leu Lys 
    690                 695                 700                 


Ala Lys Ile Lys Phe Leu Asn Lys Leu Lys Pro Glu Asp Trp Lys Lys 
705                 710                 715                 720 


Asn Gln Tyr Phe Leu Met Leu Lys Glu Pro Lys Thr Asn Arg Lys Thr 
                725                 730                 735     


Leu Val Gln Gly Trp Lys Asn Gly Phe Asn Leu Pro Arg Gly Ile Phe 
            740                 745                 750         


Thr Glu Pro Ile Lys Glu Trp Phe Lys Arg His Gln Asn Asp Ser Glu 
        755                 760                 765             


Glu Tyr Lys Lys Val Glu Ala Leu Asp Arg Val Gly Leu Val Ala Lys 
    770                 775                 780                 


Val Ile Pro Leu Phe Phe Lys Glu Glu Tyr Phe Lys Glu Asp Ala Gln 
785                 790                 795                 800 


Lys Glu Ile Asn Asn Cys Val Gln Pro Phe Tyr Ser Phe Pro Tyr Asn 
                805                 810                 815     


Val Gly Asn Ile His Lys Pro Glu Glu Lys Asn Phe Leu His Cys Glu 
            820                 825                 830         


Glu Arg Arg Lys Leu Trp Asp Lys Lys Lys Asp Lys Phe Lys Gly Tyr 
        835                 840                 845             


Lys Ala Lys Glu Lys Ser Lys Lys Met Thr Asp Lys Glu Lys Glu Glu 
    850                 855                 860                 


His Arg Ser Tyr Leu Glu Phe Gln Ser Trp Asn Lys Phe Glu Arg Glu 
865                 870                 875                 880 


Leu Arg Leu Val Arg Asn Gln Asp Ile Leu Thr Trp Leu Leu Cys Thr 
                885                 890                 895     


Lys Leu Ile Asp Lys Leu Lys Ile Asp Glu Leu Asn Ile Glu Glu Leu 
            900                 905                 910         


Gln Lys Leu Arg Leu Lys Asp Ile Asp Thr Asp Thr Ala Lys Lys Glu 
        915                 920                 925             


Lys Asn Asn Ile Leu Asn Arg Val Met Pro Met Arg Leu Pro Val Thr 
    930                 935                 940                 


Val Tyr Glu Ile Asp Lys Ser Phe Asn Ile Val Lys Asp Lys Pro Leu 
945                 950                 955                 960 


His Thr Val Tyr Ile Glu Glu Thr Gly Thr Lys Leu Leu Lys Gln Gly 
                965                 970                 975     


Asn Phe Lys Ala Leu Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser 
            980                 985                 990         


Phe Val Lys Thr Ser Ser Glu Ala  Glu Ser Lys Ser Lys  Pro Ile Ser 
        995                 1000                 1005             


Lys Leu  Arg Val Glu Tyr Glu  Leu Gly Ala Tyr Gln  Lys Ala Arg 
    1010                 1015                 1020             


Ile Asp  Ile Ile Lys Asp Met  Leu Ala Leu Glu Lys  Thr Leu Ile 
    1025                 1030                 1035             


Asp Asn  Asp Glu Asn Leu Pro  Thr Asn Lys Phe Ser  Asp Met Leu 
    1040                 1045                 1050             


Lys Ser  Trp Leu Lys Gly Lys  Gly Glu Ala Asn Lys  Ala Arg Leu 
    1055                 1060                 1065             


Gln Asn  Asp Val Gly Leu Leu  Val Ala Val Arg Asn  Ala Phe Ser 
    1070                 1075                 1080             


His Asn  Gln Tyr Pro Met Tyr  Asn Ser Glu Val Phe  Lys Gly Met 
    1085                 1090                 1095             


Lys Leu  Leu Ser Leu Ser Ser  Asp Ile Pro Glu Lys  Glu Gly Leu 
    1100                 1105                 1110             


Gly Ile  Ala Lys Gln Leu Lys  Asp Lys Ile Lys Glu  Thr Ile Glu 
    1115                 1120                 1125             


Arg Ile  Ile Glu Ile Glu Lys  Glu Ile Arg Asn 
    1130                 1135                 


<210>  1866
<211>  1221
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1866

Met Asp Ile Arg Leu Ser Lys Asn Arg Ala Leu Leu Ala Ala Tyr Leu 
1               5                   10                  15      


Asn Met Ala Gln Gln Asn Val Tyr Val Thr Leu Leu His Ile Ser Gln 
            20                  25                  30          


Leu Met Gly Val Glu Glu Thr Lys Asp Leu Ser Asn Arg Met Tyr Asp 
        35                  40                  45              


Phe Gln Ile Leu Gln Glu Leu Lys Thr Gly Lys Lys Gly Ala Glu Ser 
    50                  55                  60                  


Glu Gln Met Val Lys Ser Glu Arg Val Gln Lys Ile Ile Leu Leu Leu 
65                  70                  75                  80  


Tyr Arg Asn Phe Pro Phe Leu Lys Ala Phe Val Glu Ala Lys Tyr Lys 
                85                  90                  95      


Gln Gln Glu Lys Asn Asn Gly Gly Lys Asn Lys Gly Gly Gly Lys Asn 
            100                 105                 110         


Thr Gln Lys Asn Lys Asn Asn Ala Ser Asn Glu Glu Gln Leu Glu Phe 
        115                 120                 125             


Thr Glu Ser Glu Leu Gly Lys Leu Pro Ile Pro Pro His Glu Tyr Arg 
    130                 135                 140                 


Thr Ile Leu Cys Asp Val Phe Arg Leu Ile Asn Asp Leu Arg Asn Glu 
145                 150                 155                 160 


Tyr Thr His Phe Ser Pro Glu Lys Arg Thr Gly Gly Ala Lys Glu Ser 
                165                 170                 175     


His Glu Lys Cys Gln Lys Lys Met Leu Ser Tyr Leu Tyr Leu Cys Leu 
            180                 185                 190         


Asp Gly Gly Arg Arg Val Val Lys Glu Arg Phe Lys Asp Thr Phe Gln 
        195                 200                 205             


Glu Asn Asp Phe Asn Phe Leu Thr Gln Gly Pro Arg Tyr Ser Leu Gln 
    210                 215                 220                 


Lys Asp Gly Asp Lys Lys Lys Ala Glu Glu Arg Pro Asn Phe Tyr Tyr 
225                 230                 235                 240 


Arg Leu Lys Asp Asp Gln Gly Leu Phe Ser Tyr Val Gly Ile Leu Leu 
                245                 250                 255     


Phe Ile Ser Leu Phe Leu His Lys Arg Tyr Ile Ser Glu Met Leu Ala 
            260                 265                 270         


Gln Ser Gly Leu Phe Tyr Thr Pro Arg Tyr Trp Lys Gly Gln Pro Val 
        275                 280                 285             


Asn Val Glu Leu Glu Arg Arg Ile Ile Ser Glu Ile Phe Ser Ile Tyr 
    290                 295                 300                 


Arg Ile Arg Leu Pro Lys Glu Arg Ile Asp Ser Thr Arg Pro Asp Tyr 
305                 310                 315                 320 


Ala Leu Gly Leu Asp Met Leu Asn Glu Leu Gln Lys Cys Pro Asn Glu 
                325                 330                 335     


Leu Tyr Glu Thr Phe Ser Pro Lys Asp Gln Ala Glu Phe Arg Val Lys 
            340                 345                 350         


Arg Glu Tyr Asp Glu Ser Gly Glu Gly Thr Glu Glu Gly Glu Val Leu 
        355                 360                 365             


Leu Lys Arg Phe Glu Asp Arg Phe Pro Tyr Phe Ala Ile Arg Tyr Leu 
    370                 375                 380                 


Asp Glu Asn Arg Val Phe Asp Asp Ile Arg Phe Gln Val Ser Ile Gly 
385                 390                 395                 400 


Lys Tyr Arg Tyr Lys Phe Tyr Asn Lys Leu Cys Ile Asp Val Val Ser 
                405                 410                 415     


Ser Asn Arg Asn Asp Asp Cys Tyr Arg Leu Arg Ser Leu Gln Lys Glu 
            420                 425                 430         


Ile Asn Gly Phe Gly Arg Leu Asn Glu Val Glu Tyr Glu Arg Ile Leu 
        435                 440                 445             


Arg Tyr Gly Ser His Ile His Val Glu Lys Pro Glu Gly Asp Asp Thr 
    450                 455                 460                 


Pro Tyr Leu Thr Asp His His Thr Ser Tyr Leu Phe Asn Gly Asn Arg 
465                 470                 475                 480 


Ile Gly Leu Leu Phe Asn Gln Glu Asn Gly Arg His Asp Leu Glu Glu 
                485                 490                 495     


Ile Arg Gly Asn Cys Leu Tyr Leu Pro His Leu Thr Phe Ala Ser Ser 
            500                 505                 510         


Ser Glu Gly Lys Asp Ala Arg Arg Val Pro Pro Ile Ala Trp Leu Ser 
        515                 520                 525             


Thr Tyr Glu Leu Pro Ala Leu Ile Phe His His Leu Leu Cys Arg His 
    530                 535                 540                 


Tyr Gly Leu Glu Arg Thr Ala Thr Glu Ser Ile Ile Lys Glu Cys Val 
545                 550                 555                 560 


Gly Leu Tyr His Arg Leu Phe Thr Asp Ile Arg Asp Gly Lys Leu Leu 
                565                 570                 575     


Pro Gly Glu Ala Leu Gly Ile Gln Ala Glu Glu Ser Thr Arg Ser Glu 
            580                 585                 590         


Ile Ser Arg Ile Lys Lys Gly Glu Pro Leu Pro Gln Asn Ile Ser Glu 
        595                 600                 605             


Lys Ile Glu Thr Phe Leu Ser Thr His Tyr Cys Thr Glu Gln Val Cys 
    610                 615                 620                 


Leu His Ile Gln Asp Ile Pro Lys Lys Ile Ile Asp Tyr Leu Ile Gly 
625                 630                 635                 640 


Lys Asn Ile Asp Gln Asp Met Ser Gly Leu Phe Lys Gln Arg Ser Arg 
                645                 650                 655     


Glu Arg Ile Asn Lys Met Tyr Glu Ser Thr Lys Ile Arg Leu Lys Lys 
            660                 665                 670         


Phe Lys Thr Asp Leu Asp Leu Gln Gly Asn Gly Asp Asn Lys Phe Gly 
        675                 680                 685             


Lys Lys Arg Tyr Thr Asp Ile Arg Pro Gly Gln Leu Ala Asp Tyr Leu 
    690                 695                 700                 


Ala Lys Asp Leu Leu Phe Phe Gln Pro Tyr Asp Asp Glu Lys Lys Asn 
705                 710                 715                 720 


Lys Val Thr Gly Leu Asn Tyr Gln Ile Leu Gln Ala Ala Leu Ala Ile 
                725                 730                 735     


Tyr Asn His Asn Leu Asp Glu Leu Arg Arg Leu Phe Lys Asn Ala Arg 
            740                 745                 750         


Leu Leu Val Pro Glu Asn Pro Lys Met Glu His Pro Phe Leu Gly Ser 
        755                 760                 765             


Val Leu His Lys Ser Pro Arg Thr Thr Leu Gln Phe Tyr Ala Tyr Tyr 
    770                 775                 780                 


Leu Leu Glu Lys Ile Ser Tyr Leu Lys Lys Arg Leu Asp Asp Pro Asn 
785                 790                 795                 800 


Glu Thr Phe Ala Asp Leu Phe Arg Tyr Lys Gln Arg Gln Lys Trp Gln 
                805                 810                 815     


Thr Arg Asp Ser Gln Trp Tyr Arg Ala Leu Ala Gly Arg Tyr Met Ala 
            820                 825                 830         


Glu Met Met Glu Glu Gly Thr Met Asn Phe Lys Pro Val Glu Leu Pro 
        835                 840                 845             


Arg Gly Leu Phe Glu Arg Pro Ile Lys Arg Leu Leu Thr Asn Ile Leu 
    850                 855                 860                 


Thr Lys Arg Thr Asp Ser Asp Ser Gln Ala Leu Leu Lys Ile Val Glu 
865                 870                 875                 880 


Ser Pro Arg Cys Asn Val Ser Tyr Leu Ile Ala Gln Tyr Phe Thr Leu 
                885                 890                 895     


Ile Leu His Asp Asp Ser Gln Pro Phe Tyr His Pro Asn Lys Arg Tyr 
            900                 905                 910         


Lys Arg Thr Tyr Gln Tyr Phe Asn Ile Leu Asn Asn Arg Lys Glu Arg 
        915                 920                 925             


Asn Lys Leu Val Gln Val Tyr Tyr Thr Leu Asp Glu Met Glu Ala Tyr 
    930                 935                 940                 


Phe Lys Asp Thr Glu Ser Leu Lys Lys Arg Tyr Lys Asp Tyr Leu Thr 
945                 950                 955                 960 


Ser Ser Glu Ala Lys Lys His Pro Ala Pro Glu Gln Arg Leu Lys Lys 
                965                 970                 975     


Tyr Leu Ser Glu Tyr Arg Lys Asn Glu Thr Thr Ile Arg Arg Tyr Arg 
            980                 985                 990         


Val Gln Asp Met Leu Val Phe Leu  Met Ala Lys Ile Leu  Leu Leu Glu 
        995                 1000                 1005             


Lys Gly  Gly Leu Glu Ala Gly  Glu Leu Glu Gln Tyr  Lys Leu Ser 
    1010                 1015                 1020             


His Ile  Gln Pro Thr Thr Gly  Gln Asn Ser Gly Gln  Asn Ile Leu 
    1025                 1030                 1035             


Ser Leu  Gln Val Pro Phe Asn  Ile Thr Val Lys Leu  Asp Asp Gly 
    1040                 1045                 1050             


Thr Glu  Arg Ser Ile Thr Gln  Glu Ala Ile Lys Val  Lys Asn Tyr 
    1055                 1060                 1065             


Gly Asp  Phe Phe Arg Phe Leu  Tyr Asp Asp Arg Val  Ala Ser Leu 
    1070                 1075                 1080             


Leu Pro  Tyr Thr Gln Glu Asp  Ile Pro Leu Glu Arg  Ala Leu Leu 
    1085                 1090                 1095             


Glu Lys  Glu Leu Glu Gly Tyr  Asp Arg Glu Arg Ile  Pro Ile Phe 
    1100                 1105                 1110             


Lys Ser  Val His Cys Met Glu  Lys Glu Ile Leu Arg  Leu Cys Pro 
    1115                 1120                 1125             


Glu Leu  Asn Asp Pro Gln Ser  Ser Gln Tyr Lys Tyr  Thr Thr Asp 
    1130                 1135                 1140             


Ile Gly  Thr Glu Lys Ile Val  Lys Glu Asn Phe Arg  Ala Met Leu 
    1145                 1150                 1155             


Thr Glu  Leu Cys Ser Arg Gly  Leu Leu Pro Glu Asn  Glu Ile Glu 
    1160                 1165                 1170             


Met Met  Val Glu Ile Arg Asn  Ser Phe Ser His Asn  Arg Tyr Ala 
    1175                 1180                 1185             


Cys Val  Asn Leu Lys Gly Lys  Asn Ile Pro Met Ile  Ala Ile Ser 
    1190                 1195                 1200             


Ile Gln  Arg Lys Phe Asp Gly  Val Val Gly Arg Thr  Ile Gly Lys 
    1205                 1210                 1215             


Asn Lys  Asn 
    1220     


<210>  1867
<211>  1034
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1867

Met Asn Phe Ser Glu Asn Asn Lys Tyr Leu Tyr Gly Ala Tyr Phe Asn 
1               5                   10                  15      


Thr Ala Leu Asp Asn Phe Lys Asp Val Ile Arg His Ile Tyr Arg Ile 
            20                  25                  30          


Ile Lys Leu Ile Asp Gly Val Asp Val Lys Ile Ser Phe Gly Asp Tyr 
        35                  40                  45              


Asp Thr Gln Tyr Asp Tyr Leu Ser Lys Lys Leu Lys Asp Arg Asn Ala 
    50                  55                  60                  


Thr Ser Gln Lys Val Glu Glu Leu Leu Tyr Gly Ala Phe Pro Phe Trp 
65                  70                  75                  80  


Gly Lys Leu Met Ser Ile Ile Ser Ser Glu Trp Lys Arg Glu Glu Asn 
                85                  90                  95      


Thr Asn Tyr Asn Asp Ile Ser Ala Lys Cys Val Asp Gly Ile Ala Ile 
            100                 105                 110         


Ile His Lys Val Leu Glu Asp Trp Arg Asn Tyr Thr Thr His Gly Gln 
        115                 120                 125             


His Glu Glu Ala Asn Ile Asn Glu Ser Val Leu Tyr Leu Leu Lys Asp 
    130                 135                 140                 


Met Tyr Asp Val Ser Val Lys Thr Ile Ile Glu Arg Phe Ser Leu Thr 
145                 150                 155                 160 


Asn Ser Asp Val Thr His Leu Ser Lys Arg Ile Glu Lys Lys Asp Lys 
                165                 170                 175     


Glu Gly Lys Asn Ala Lys Val Lys Tyr Gln Pro Ala Gly Tyr Tyr Ala 
            180                 185                 190         


Phe Leu Asp Asp Ser Lys Ser Ile Thr Glu Lys Gly Leu Ala Phe Leu 
        195                 200                 205             


Ile Cys Leu Phe Leu Lys Lys Glu Glu Ala Tyr His Phe Leu Lys Ser 
    210                 215                 220                 


Ile Lys Gly Phe Lys Arg Asp Asp Asp Ile His Tyr Arg Met Thr Leu 
225                 230                 235                 240 


Glu Val Phe Thr Ala Met Arg Tyr His Ala Pro Lys Arg Leu Met Arg 
                245                 250                 255     


Leu Glu Gln Lys Ser Gly Asp Lys Val Ser Leu Ala Met Glu Met Ile 
            260                 265                 270         


Asn Glu Leu Ala Lys Cys Pro Lys Glu Leu Tyr Glu His Leu Ser Pro 
        275                 280                 285             


Glu Glu Lys Lys Lys Phe Glu Ile Tyr Glu Glu Gly Glu Gln Gly Glu 
    290                 295                 300                 


Val Ile Gly Asp Leu Ile Arg Tyr Lys Asp Arg Tyr Glu Ile Leu Met 
305                 310                 315                 320 


Met Lys Ala Leu Glu Phe Ser Gly Glu Cys Gln Asp Met Gly Phe Tyr 
                325                 330                 335     


Met His Leu Ser Lys Cys Tyr Met Asn Cys Tyr Glu Lys Thr Phe Ile 
            340                 345                 350         


Asp Gly Thr Lys Asp Asn Arg Tyr Ile Thr Phe Ser Leu Cys Gly Phe 
        355                 360                 365             


Gly Arg Leu Gln Asn Ser Tyr Ile Lys Pro Glu Asn Ile Ser Thr Val 
    370                 375                 380                 


Val Asp Glu Glu Tyr Glu Thr Ser Glu Asn Leu Ser Ser Lys Lys Glu 
385                 390                 395                 400 


Cys Leu Ser Asn Phe Gly Glu Met Leu His Glu Ser Ser Ser Met Arg 
                405                 410                 415     


Val Gln His Ser Phe Ser Glu Gln Glu Phe Asn Asn Ser Ala Ile Asn 
            420                 425                 430         


Val Glu Val Pro Tyr Ile Ser Glu Ser Tyr Pro Ser Tyr Ile Val Asn 
        435                 440                 445             


Asp Asn Lys Ile Gly Ile Lys Arg Leu Gln Ser Pro Ser Asp Thr Ile 
    450                 455                 460                 


Leu Pro Glu Phe Asp Ile Ala Asn Lys Lys Val Ser Cys Pro Lys Pro 
465                 470                 475                 480 


Asp Tyr Trp Leu Ser Lys Tyr Glu Leu Pro Ser Met Ala Phe Tyr Ala 
                485                 490                 495     


Tyr Leu Lys Glu Val His Lys Asp Lys Leu Ser Ser Phe Pro Thr Ile 
            500                 505                 510         


Trp Glu Ile Ile Glu Arg Asp Lys Pro Gln Ser His Ala Ser Gln Asn 
        515                 520                 525             


Ser Pro Lys Lys Ile Lys Glu Leu Glu Glu Glu Arg Leu Lys Lys Tyr 
    530                 535                 540                 


Leu Ser Glu Ile Glu Ile Lys Ile Ser Glu Leu Ser Asn Asn Asp Val 
545                 550                 555                 560 


Ile Leu Lys Asn Gly Asn Ile Ala Asp Glu Leu Ala Arg Asp Ile Leu 
                565                 570                 575     


Trp Leu Gln Pro Ser Val Asn Lys Gly Lys Asp Lys Leu Thr Gly Ala 
            580                 585                 590         


Asn Phe Arg Thr Leu Gln Tyr Ala Leu Ala Arg Tyr Ser Phe Val Lys 
        595                 600                 605             


Glu Gln Leu Ala Asp Ile Tyr Lys Lys Gly Gly Leu Ile Glu Ser Lys 
    610                 615                 620                 


Asn Gly Asn Asn His Pro Phe Leu Ala Asp Ile Leu His Asn Gly Phe 
625                 630                 635                 640 


Glu Ser Leu Lys Asp Tyr Tyr Lys Gly Tyr Leu Cys Lys Lys Lys Lys 
                645                 650                 655     


Phe Ile Gln Thr Gln Leu Leu Lys Ile Glu Lys Gly Lys Thr Asn Ile 
            660                 665                 670         


Asn Phe Tyr Pro Phe Arg Lys Leu Val Asn Glu Lys Asp Lys Thr Gln 
        675                 680                 685             


Lys Ser Ser Glu Asn Glu Pro Val Phe Leu Ser Arg Asn Leu Phe Ala 
    690                 695                 700                 


Glu Asn Ile Lys Lys Ala Leu Cys Ala Ile Arg Gly Asp Leu Lys Ser 
705                 710                 715                 720 


Asn Ile Glu Arg Met Glu Ile Glu Thr Lys Arg Val Asn Thr Ala Lys 
                725                 730                 735     


Leu Ile Gln Ile Tyr Phe Gln Ser Phe Leu Lys Asp Ser Ser Gln Phe 
            740                 745                 750         


Phe Tyr Leu Thr Asp Arg Lys Tyr Asp Glu Leu Asn Ser Glu Ile Lys 
        755                 760                 765             


Asp Gly Ser Lys Tyr Leu Ser Leu Asn Met Arg Asp Lys Ile Ile Lys 
    770                 775                 780                 


Asp Lys Lys Glu Ser Gly Gln Met Asn Asp Gly Ile Lys Asp Val Leu 
785                 790                 795                 800 


Glu Ser Glu Lys Ile Ile Arg Leu Arg Ser Ile Gln Asp Met Thr Leu 
                805                 810                 815     


Phe Leu Trp Met Lys Glu Phe Ser Asn Ile Asp Phe Ile Asp Lys Ile 
            820                 825                 830         


Met Leu Lys Asp Ile Asp Asn Ala Phe Leu Ser Lys Pro Ile Ser Ile 
        835                 840                 845             


Asn Met Phe Ile Glu Thr Ile Gln Ile Lys Cys Lys Val Lys Ile Lys 
    850                 855                 860                 


Asp Tyr Gly Arg Ile Ser Ser Ile Ile Val Ser Asn Ser Leu Ser Arg 
865                 870                 875                 880 


Ser Leu Ile Lys Phe Ile Ser Ser Val Tyr Lys Glu Asn Asn Leu Lys 
                885                 890                 895     


Arg Gln Asp Lys Glu Val Leu Ser Tyr Asn Tyr Ile Phe Lys Glu Ile 
            900                 905                 910         


Asn Thr Phe Val Lys Tyr Arg Pro Glu Ile Ile Arg Leu Ala Gln Ser 
        915                 920                 925             


Ile Glu Glu Lys Leu Leu Glu Tyr Ser Lys Glu Glu Ile Ser Ser Glu 
    930                 935                 940                 


Gly Ser Tyr Tyr Asn Phe Arg Val Val Ala Thr Thr Ala Leu Glu Asp 
945                 950                 955                 960 


Met Pro Asp Ile Asp Lys Glu Val Leu Ile Asp Ile Arg Asn Gly Phe 
                965                 970                 975     


Cys His Asn Ser Tyr Pro Glu Asn Ser Ile Cys His Lys Glu Tyr Tyr 
            980                 985                 990         


Gln Ile Lys Arg Lys Glu Asp Ser  Phe Gly Phe Ser Ala  Glu Glu Gly 
        995                 1000                 1005             


Ile Lys  Glu Glu Asn Thr Ile  Ala His Tyr Leu Tyr  Glu Lys Phe 
    1010                 1015                 1020             


Arg Leu  Glu Gln Glu Lys Ile  Met Lys Leu Glu 
    1025                 1030                 


<210>  1868
<211>  1062
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1868

Met Asn Phe Glu Glu Asn Gly Asn Lys Tyr Leu Phe Gly Ala Phe Leu 
1               5                   10                  15      


Asn Thr Ala Tyr Asp Asn Tyr Asn Glu Val Ile Ser His Ile Tyr Asp 
            20                  25                  30          


Val Ile Arg Arg Ile Thr Asn Asn Asn Pro Thr Glu Gln Lys Ser Ser 
        35                  40                  45              


Ser Gln Ala Leu Ala Ser Glu Glu Pro Ile Ser Ser Glu Glu Lys Glu 
    50                  55                  60                  


Lys Met Phe Phe Val Cys Thr Ile Leu Ile Ala Gly Asn Ala Thr Ser 
65                  70                  75                  80  


Arg Lys Ile Glu Ser Ile Leu Lys Arg Ala Phe Pro Phe Trp Asp Asp 
                85                  90                  95      


Phe Ile Glu Ile His Ala Ser Leu Ser Ala Gln Leu Asp Lys Thr Glu 
            100                 105                 110         


Ser Ile Phe Gln Leu Gln Lys Asn Cys Val Glu Glu Leu Phe Thr Ala 
        115                 120                 125             


Leu Glu Ser Trp Arg Asn Tyr Thr Thr His Tyr Ile His Pro Glu Ala 
    130                 135                 140                 


Ile Ala Ser Pro Thr Ile Asn Leu Leu Leu Lys Ser Cys Phe Asn Gln 
145                 150                 155                 160 


Gly Ile Lys Glu Ile Lys Lys Arg Phe Asn Thr Lys Asp Glu Gln Leu 
                165                 170                 175     


Thr His Leu Tyr Glu Pro Glu Leu Phe His Asn Lys Glu Thr Asn Lys 
            180                 185                 190         


Asp Glu Ile Lys Cys Tyr His Pro Ala Asn Tyr Tyr Arg Phe Ala Asn 
        195                 200                 205             


Glu Asn Gly Leu Leu Thr Glu Lys Gly Leu Ala Phe Phe Thr Cys Leu 
    210                 215                 220                 


Phe Leu Tyr Lys Arg Glu Ser Tyr Leu Leu Leu Asn Gln Leu Lys Gly 
225                 230                 235                 240 


Phe Lys Arg Ala Asp Glu Glu Arg Tyr Arg Met Thr Leu Glu Ala Phe 
                245                 250                 255     


Thr Val Met Arg Phe Arg Ala Pro Lys Gln Leu Leu Lys Leu Gln Gln 
            260                 265                 270         


Gln Gln Leu Asp Lys Val Ser Leu Gly Ile Ser Met Ile Asn Glu Leu 
        275                 280                 285             


Ala Lys Cys Pro Lys Glu Leu Tyr Asp Cys Leu Glu Asn Glu Lys Arg 
    290                 295                 300                 


Arg Gln Phe Glu Val Tyr Pro Asp Thr Glu Thr Thr Leu Tyr Glu Gln 
305                 310                 315                 320 


Glu Ala Ile Gly Glu Leu Ile Arg Tyr Lys Asp Arg Tyr Glu Asn Leu 
                325                 330                 335     


Met Leu Lys Ala Leu Glu His Ser Ser Glu Cys Lys Tyr Met Gly Phe 
            340                 345                 350         


Tyr Leu Ser Leu Gly Lys Cys Tyr Met Lys Cys Tyr Glu Lys His Tyr 
        355                 360                 365             


Ile Asp Gly Thr Thr Asp Asn Arg Tyr Ile Val His Ser Leu Tyr Gly 
    370                 375                 380                 


Phe Gly Arg Leu Gln Asn Ala Ser Thr Asp His Lys Asn His Leu Ser 
385                 390                 395                 400 


Ser Phe Gly Glu Glu Leu Gln Thr His Ser Gln Leu Pro Val Cys His 
                405                 410                 415     


Phe Ala Thr Glu Asp Asp Ala Ala Asp Ser Pro Thr Ser Val Pro Tyr 
            420                 425                 430         


Ile Ser Glu Ser Tyr Pro Ser Tyr Val Leu Asn Asn Asn Asn Ile Gly 
        435                 440                 445             


Ile Lys Trp Leu Asn Ser Ser Glu Lys Thr Glu Tyr Pro Asn Phe Asn 
    450                 455                 460                 


Leu Asn Glu Gly Lys Val Ser Cys Pro Ala Pro Asp Tyr Trp Leu Ser 
465                 470                 475                 480 


Lys Tyr Glu Leu Pro Ala Met Ala Phe Tyr Ala Tyr Leu Lys Glu Lys 
                485                 490                 495     


His Lys Asn Lys Leu Gln Glu Tyr Pro Ser Ile Lys Glu Leu Ile Asp 
            500                 505                 510         


Gln Ser His Pro Glu Ala Thr Lys Thr Ser Ser Ser Thr Ile Lys Asp 
        515                 520                 525             


Arg Leu Glu Glu Arg Leu Lys Arg Tyr Lys Val Asp Ala Thr Lys Lys 
    530                 535                 540                 


Leu Lys Arg Leu Ala Glu Lys Pro Asp Gly Val Gln Ser Gly Arg Leu 
545                 550                 555                 560 


Ala Asp Glu Leu Ala Arg Asp Ile Leu Trp Leu Gln Pro Ser Ser Pro 
                565                 570                 575     


Lys Glu Gly Gly Lys Asp Lys Leu Thr Gly Ala Asn Phe Gln Ala Leu 
            580                 585                 590         


Gln Tyr Ala Leu Ala Arg Tyr Asp Phe Met Arg Thr Glu Leu Pro Arg 
        595                 600                 605             


Ile Leu Thr Ala Ala Arg Leu Thr Gly Ser Asn Asn Ala His Pro Phe 
    610                 615                 620                 


Leu Asp Lys Ile Asn Pro Gln Asp Tyr Ser Arg Leu Thr Ala Tyr Tyr 
625                 630                 635                 640 


Ala Gly Tyr Leu Thr Gln Lys Ile Val Tyr Ile Asp Lys Gln Leu Glu 
                645                 650                 655     


Lys Leu Ala Arg Gly Lys Val Asn Ile Gln Phe His Pro Thr Arg Lys 
            660                 665                 670         


Leu Ile Arg Gln Ser Gln Thr Asp Ser Val Glu His Glu Lys Glu Thr 
        675                 680                 685             


Val Phe Leu Pro Arg Asn Ile Phe Thr Glu Lys Ile Glu Gln Ala Leu 
    690                 695                 700                 


Cys Gln Ile Gln Gly Asn Phe Lys Leu Asn Ile Glu Lys Ala Arg Ile 
705                 710                 715                 720 


Ser Gly Lys Lys Leu Asn Ala Ser Lys Leu Ile Leu Ile Tyr Leu Glu 
                725                 730                 735     


Leu Tyr Leu Lys Asp Glu Val Pro Glu Phe Tyr Asn Ala Lys Arg Lys 
            740                 745                 750         


Tyr Pro Cys Leu Cys Tyr Pro Leu Thr Pro Ser Glu Lys Tyr Thr Leu 
        755                 760                 765             


Lys Glu Tyr Gln Asp Thr Glu Glu Arg Ser Lys Arg Ile Asp Arg Leu 
    770                 775                 780                 


Lys Cys Phe Tyr Asn Phe Lys Glu Val Ala Glu Lys Val Tyr Leu His 
785                 790                 795                 800 


Lys Glu Leu Ser Glu Asp Glu Asn Lys Arg Tyr Arg Lys Tyr Ile Glu 
                805                 810                 815     


Val Gln Lys Val Ile Asp Asn Glu Lys Ile Ile Arg Leu Arg Lys Val 
            820                 825                 830         


Gln Asp Ile Thr Leu Tyr Leu Trp Thr Arg Leu Phe Ile Glu Glu Asn 
        835                 840                 845             


Pro Glu Gln Ile Phe Phe Ser Lys Asn Glu Lys Pro Glu Asn Ser Leu 
    850                 855                 860                 


Phe Lys Leu Arg Glu Met Asn Asn Ala Ile Leu Asp Asn Thr Thr Ser 
865                 870                 875                 880 


Arg Lys Ile Asn Ile Asn Thr Pro Asn Gly Asn Val Ser Ile Glu Asp 
                885                 890                 895     


Glu Phe Lys Ile Lys Asp Tyr Gly Arg Val Thr Ala Leu Thr Thr Glu 
            900                 905                 910         


Lys Leu Pro Gln Ser Leu Ile Lys Phe Ile Ala Ile Leu Asn Lys Pro 
        915                 920                 925             


Leu Asn Lys Lys Asp Arg Pro Leu Leu Ser Tyr Asp Tyr Ile Tyr His 
    930                 935                 940                 


Glu Thr Asn Ala Phe Tyr Arg Tyr Arg Pro Glu Ile Ile Lys Met Ala 
945                 950                 955                 960 


Gln Asp Ile Glu Asn Lys Ile Ile Asn Asp Leu Lys Ile Asn Val Lys 
                965                 970                 975     


Pro Gln Ala Glu Ser Tyr Tyr Asn Phe Arg Arg Thr Ile Gln Lys Leu 
            980                 985                 990         


Glu Asn Lys Ser Arg Asp Ile Asn  Ile Glu Leu Leu Ile  Lys Ile Arg 
        995                 1000                 1005             


Asn Ala  Phe Cys His Asn Glu  Tyr Lys Glu Leu Asp  Asn Asp Gln 
    1010                 1015                 1020             


Tyr Lys  Tyr Leu Asn Ser Leu  Phe Lys Leu Ser Ser  Asp Ile Lys 
    1025                 1030                 1035             


Gln Thr  Asp Thr Leu Ala Tyr  Leu Leu Tyr Ile Leu  Phe Glu Thr 
    1040                 1045                 1050             


Glu Tyr  Gln Lys Val Met Ile  Leu Lys 
    1055                 1060         


<210>  1869
<211>  1147
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1869

Met Lys Glu Ser Ile Lys Gln Gly Lys Gly Lys Glu Tyr Asn Ser Phe 
1               5                   10                  15      


Lys Thr Glu Asp Lys His Tyr Phe Gly Gly Phe Phe Asn Leu Ala Asp 
            20                  25                  30          


Asn Asn Ile Glu Glu Ala Leu Lys Glu Val Gly Gln Arg Leu Asn Thr 
        35                  40                  45              


Thr Leu Asp Ser Lys Lys Leu Ile Asp Lys Tyr Thr Lys Glu Thr Ile 
    50                  55                  60                  


Ser Leu Val Asp Tyr Glu Arg Phe Ile His Leu Leu Thr Asp Tyr Phe 
65                  70                  75                  80  


Pro Ile Val Asn Glu Ile Asp Gln Ile Asn Lys Lys Asp Asp Lys Gly 
                85                  90                  95      


Asn Ile Ile Ser Asn Thr Lys Ile Glu Arg Leu Glu Asn Phe Lys Glu 
            100                 105                 110         


Thr Phe Leu Leu Leu Ile Asn Ser Ile Asp Glu Leu Arg Asn Tyr Tyr 
        115                 120                 125             


Thr His Tyr His His Asp Pro Ile Gln Leu Glu Pro Lys Leu Phe Ala 
    130                 135                 140                 


Phe Leu Asp Asp Val Leu Leu Lys Thr Val Leu Asp Thr Lys Lys Asn 
145                 150                 155                 160 


Tyr Leu Lys Met Asp Lys Thr Lys Glu Met Met Lys Asp Ser Leu Lys 
                165                 170                 175     


Glu Asp Tyr Lys Lys Ile Phe Asp Leu Lys Val Gln Asp Tyr Leu Ser 
            180                 185                 190         


Lys Asp Asn Leu Thr Ser Lys Lys Ile Lys Lys Ala Arg Lys Tyr Gly 
        195                 200                 205             


Asn Gly Phe Asp Asp Lys Leu Thr Asn Glu Ile Glu His Ser Ile Tyr 
    210                 215                 220                 


Asn Asp Thr Ile Lys Asp Phe Ile Tyr Asp Lys Ser Lys Lys Ala Glu 
225                 230                 235                 240 


Leu Thr His Ala Arg Lys Thr Ser Phe Asn Asp Lys Asp Pro Phe Val 
                245                 250                 255     


Lys Asn Lys Asp Phe Asp Leu Pro Ile Ser Ser Asn Gly Ile Ile Phe 
            260                 265                 270         


Leu Leu Ser Leu Phe Leu Asn Arg Lys Glu Ile Glu Asn Leu Lys Ala 
        275                 280                 285             


Asn Ile Lys Gly Tyr Lys Gly Lys Val Asn Lys Ser Glu Glu Pro Thr 
    290                 295                 300                 


Leu Glu Lys Asn Asn Ile Arg Phe Met Thr Thr His Arg Ile Phe Ser 
305                 310                 315                 320 


Phe Trp His Tyr Lys Gly Leu Lys Ser Lys Ile Lys Thr Ser Glu Asn 
                325                 330                 335     


Ala Thr Lys Glu Thr Leu Leu Met Gln Met Ile Asp Glu Leu Ser Lys 
            340                 345                 350         


Val Pro Asp Val Ile Tyr Gln Asn Val Pro Lys Asp Val Gln Asp Ser 
        355                 360                 365             


Phe Ile Glu Asn Trp Asn Glu Tyr Tyr Lys Asp Asn Glu Glu Asn Gln 
    370                 375                 380                 


Glu Asn Leu Glu Asn Ser Lys Val Val His Pro Val Ile Arg Lys Arg 
385                 390                 395                 400 


Tyr Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Tyr 
                405                 410                 415     


Val Asp Phe Pro Thr Leu Arg Phe Gln Val His Leu Gly Asn Tyr Leu 
            420                 425                 430         


Glu Asp Ser Arg Ala Lys Lys Ile Gly Asn Val Phe Thr Glu Arg Glu 
        435                 440                 445             


Ile Lys Lys Lys Leu Phe Val Phe Gly Lys Leu Asn Glu Ile Asn Gln 
    450                 455                 460                 


Leu Lys Ser Asp Phe Phe Gln Glu Ile Lys Glu Lys Lys Glu Glu Thr 
465                 470                 475                 480 


Gln Trp Glu Ile Phe Pro Asn Pro Ser Tyr His Phe Pro Met Glu Asn 
                485                 490                 495     


Ser Glu Glu Leu Lys Ala Ala Asn Lys Ile Gly Ile Tyr Ile Asp His 
            500                 505                 510         


Glu Lys Ser Ile Asn Lys Tyr Lys His Gln Ala Lys Lys Leu Ser Ser 
        515                 520                 525             


Asp Ala Lys Lys Asn Leu Ile Glu Glu Ile Ile Gly Ser Lys Ser Lys 
    530                 535                 540                 


Met Ala Ile Gly Gln Pro Ile Ala Tyr Leu Ser Met Asn Asp Ile His 
545                 550                 555                 560 


Ser Ile Ile Phe Glu Ala Leu Glu Lys Leu Thr Ile Glu Glu Gly Lys 
                565                 570                 575     


Ile Asn Gly Lys Ala Ile Glu Glu Lys Ile Lys Arg Gln Ile Asn Lys 
            580                 585                 590         


Gln Ile Asp Glu Ile Ile Asn Arg Asp Glu Lys Ala Lys Ile Ile Lys 
        595                 600                 605             


Asn His Ser Lys Lys Glu Val Thr Asp Phe Asn Ile Glu Lys Leu Ile 
    610                 615                 620                 


Asp Asp Val Lys Lys Glu Ile Glu Ile Thr Cys Asn Leu Glu Lys Lys 
625                 630                 635                 640 


Leu Thr Glu Lys Glu Asn Lys Tyr Lys Ala Tyr Gln Lys Ile Lys Gly 
                645                 650                 655     


Ser Arg Asn Val Lys Thr Glu Lys Arg Asn His Val Leu Tyr Asn Ser 
            660                 665                 670         


Glu Lys Gly Glu Ile Ala Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe 
        675                 680                 685             


Phe Pro Lys Glu Phe Lys Glu Ser Trp Lys Gly Tyr Gln His Asn Glu 
    690                 695                 700                 


Phe Gln Leu Asn Leu Ala Tyr Tyr Asp Thr Gln Lys Gln Ser Val Glu 
705                 710                 715                 720 


Leu Leu Leu Ile Gly Leu Asn Tyr Gln Lys Glu Ile Pro Met Ile Tyr 
                725                 730                 735     


Phe Ser Lys Ile Ser Phe Leu Glu Phe Tyr Glu Glu Tyr Leu Lys Lys 
            740                 745                 750         


Arg Lys Lys Tyr Phe Thr Asn Leu Leu Ala Asp Leu Glu Lys His Lys 
        755                 760                 765             


Lys Gly Glu Pro Ile Asn Lys Asp Lys Leu Leu Thr Lys Cys Phe Thr 
    770                 775                 780                 


Val Phe Lys Lys Lys Asn Tyr Gln Asn Lys Ala Leu Asp Glu Lys Ile 
785                 790                 795                 800 


Lys Thr Thr Leu Ala Ser Pro Ile Phe Ile Glu Arg Gly Phe Leu Asp 
                805                 810                 815     


Ser Lys Pro Thr Val Ile Ala Gly Lys Lys Phe Tyr Glu Asn Lys Asn 
            820                 825                 830         


Glu Phe Ala Asp Trp Phe Val Ala Phe Lys Lys Phe Cys Asp Tyr Gln 
        835                 840                 845             


Lys Phe Tyr Asp Ile Thr Glu Tyr Pro Leu Asp Thr Lys Gln Lys Thr 
    850                 855                 860                 


Lys Thr Glu Ile Asn Lys Ile His Thr Lys Ile Tyr Thr Gln Lys Lys 
865                 870                 875                 880 


Asn Asp Trp Ala Ala Trp Lys Met Val His Phe Ile Phe Lys Asp Ile 
                885                 890                 895     


Phe Lys Gln Gly Leu Gln Asn Val Ala Leu Ser Glu Leu Tyr Gln Ser 
            900                 905                 910         


Arg Ala Glu Arg Ile Lys Asn Lys Glu Glu Lys Lys Gln Asn Phe Ile 
        915                 920                 925             


Trp Asn Arg Thr Ile Asp Leu Gln Leu Asn Glu Lys Ile Gln Ile Pro 
    930                 935                 940                 


Lys Val Lys Leu Lys Asp Ile Gly Asn Phe Arg Lys His Glu Lys Asp 
945                 950                 955                 960 


Gln Arg Val Lys Thr Phe Leu Ser Tyr Gly Asp Ile Thr Gly Trp Met 
                965                 970                 975     


Ala Tyr Leu Pro Asn Asp Trp Asn Glu Asn His Thr Glu Lys Pro Ile 
            980                 985                 990         


Asn Val Ile Asp Ile Gln Ile Asp  Glu Tyr Glu Lys Ile  Arg Gln His 
        995                 1000                 1005             


Glu Leu  Leu Lys Glu Val Gln  Thr Leu Glu Lys Glu  Ile Tyr Ser 
    1010                 1015                 1020             


Asn Val  Thr Asp Lys Gly Ala  Leu Leu Asn Glu Ile  Glu Gln Lys 
    1025                 1030                 1035             


Asp Lys  Thr Val Lys Lys Asn  Pro Asn Phe Lys Lys  Tyr Ile Val 
    1040                 1045                 1050             


Asn Gly  Leu Leu Lys Gln Ile  Lys Lys Met Asn Val  Asp Asn Phe 
    1055                 1060                 1065             


Lys Ile  Thr Gln Asp Gly Phe  Lys Phe Asn Asn Leu  Thr Lys Asp 
    1070                 1075                 1080             


Ile Leu  Asn Ser Tyr Thr Glu  Leu Glu Gln Lys Thr  Thr Leu Leu 
    1085                 1090                 1095             


Val Leu  Ile Arg Asn Lys Phe  Ala His Asn Gln Leu  Pro Asn Asn 
    1100                 1105                 1110             


Glu Val  Tyr Glu Phe Ser Gln  Asn Leu Leu Lys Arg  Glu Glu Asn 
    1115                 1120                 1125             


Gln Thr  Tyr Ala Ala Tyr Tyr  Leu Glu Ile Phe Lys  Lys Leu Lys 
    1130                 1135                 1140             


Thr Glu  Leu Gln 
    1145         


<210>  1870
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1870

Met Gly Ala Ile Lys Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Lys Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1871
<211>  1119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1871

Met Glu Asp Asp Lys Lys Thr Thr Glu Ser Ile Arg Tyr Glu Leu Lys 
1               5                   10                  15      


Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val 
            20                  25                  30          


Tyr Ile Thr Val Asn His Ile Asn Lys Met Leu Glu Glu Gly Glu Ile 
        35                  40                  45              


Asn Arg Asp Gly Tyr Glu Asn Thr Leu Glu Asn Ser Trp Asn Glu Ile 
    50                  55                  60                  


Lys Asp Ile Asn Lys Lys Asp Arg Leu Ser Lys Leu Ile Ile Lys His 
65                  70                  75                  80  


Phe Pro Phe Leu Glu Ala Thr Thr Tyr Arg Arg Asn Pro Thr Asp Thr 
                85                  90                  95      


Thr Lys Gln Lys Glu Glu Lys Gln Ala Glu Ala Gln Ser Leu Glu Ser 
            100                 105                 110         


Leu Lys Glu Ser Phe Phe Val Phe Ile Tyr Lys Leu Arg Asp Leu Arg 
        115                 120                 125             


Asn His Tyr Ser His Tyr Lys His Ser Lys Ser Leu Glu Arg Pro Lys 
    130                 135                 140                 


Phe Glu Glu Asp Leu Leu Lys Lys Met Tyr Asn Ile Phe Asn Ala Ser 
145                 150                 155                 160 


Ile Arg Leu Val Lys Glu Asp Tyr Gln Tyr Asn Lys Asn Ile Asn Pro 
                165                 170                 175     


Lys Lys Asp Phe Lys His Leu Asp Arg Lys Arg Lys Gly Lys Phe Tyr 
            180                 185                 190         


Tyr Ser Phe Ala Asp Asn Lys Gly Asn Ile Thr Glu Ser Gly Leu Leu 
        195                 200                 205             


Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Val Gln 
    210                 215                 220                 


Lys Lys Leu Glu Gly Phe Lys Cys Ser Asn Glu Ser Tyr Gln Lys Met 
225                 230                 235                 240 


Thr Asn Glu Val Phe Cys Arg Ser Arg Met Leu Leu Pro Lys Leu Arg 
                245                 250                 255     


Leu Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu Asn 
            260                 265                 270         


Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Gln Gly Asn 
        275                 280                 285             


Asp Arg Glu Lys Phe Arg Val Pro Phe Asp Pro Val Asp Glu Asp Tyr 
    290                 295                 300                 


Asp Ala Glu Gln Glu Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp 
305                 310                 315                 320 


Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Tyr Asn Glu Ile Phe 
                325                 330                 335     


Thr Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile 
            340                 345                 350         


Tyr Lys Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg His Leu Thr His 
        355                 360                 365             


Lys Leu Tyr Gly Phe Glu Arg Ile Gln Glu Phe Asp Lys Gln Asn Arg 
    370                 375                 380                 


Pro Asp Glu Trp Lys Ala Ile Val Lys Asp Ser Asp Thr Phe Lys Lys 
385                 390                 395                 400 


Lys Glu Glu Lys Glu Glu Glu Lys Pro Tyr Ile Ser Glu Thr Thr Pro 
                405                 410                 415     


His Tyr His Leu Glu Asn Lys Lys Ile Gly Ile Ala Phe Lys Asn His 
            420                 425                 430         


Asn Ile Trp Pro Ser Thr Gln Thr Glu Leu Thr Asn Asn Lys Arg Lys 
        435                 440                 445             


Lys Tyr Asn Leu Gly Thr Ser Ile Lys Ala Glu Ala Phe Leu Ser Val 
    450                 455                 460                 


His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Lys Thr Glu 
465                 470                 475                 480 


Asn Thr Lys Asn Asp Asn Lys Val Glu Gly Lys Lys Glu Thr Lys Lys 
                485                 490                 495     


Gln Glu Lys His Lys Ile Glu Ala Ile Ile Glu Ser Lys Ile Lys Asp 
            500                 505                 510         


Met Tyr Ala Leu Tyr Asp Ala Phe Ala Asn Gly Glu Ile Asn Ser Glu 
        515                 520                 525             


Lys Glu Leu Glu Glu Tyr Leu Lys Gly Lys Asp Ile Glu Ile Val His 
    530                 535                 540                 


Leu Pro Lys Gln Met Ile Ala Ile Leu Lys Asn Glu Tyr Lys Asp Met 
545                 550                 555                 560 


Ala Glu Lys Ala Glu Asp Lys Gln Glu Lys Met Lys Leu Ala Thr Glu 
                565                 570                 575     


Asn Arg Leu Lys Thr Leu Asp Lys Gln Leu Lys Gly Lys Ile Gln Asn 
            580                 585                 590         


Gly Lys Arg Tyr Asn Ser Ala Pro Lys Ser Gly Glu Ile Ala Ser Trp 
        595                 600                 605             


Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln Lys Asp Asn Glu 
    610                 615                 620                 


Gly Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln Leu 
625                 630                 635                 640 


Leu Gln Arg Thr Leu Ala Phe Phe Gly Ser Glu His Glu Arg Phe Ala 
                645                 650                 655     


Pro Tyr Phe Lys Gln Thr Lys Leu Ile Glu Ser Ser Asn Pro His Pro 
            660                 665                 670         


Phe Leu Lys Asp Thr Glu Trp Glu Lys Cys Asn Asn Ile Leu Ser Phe 
        675                 680                 685             


Tyr Arg Ser Tyr Leu Glu Ala Lys Lys Asn Phe Leu Glu Ser Leu Lys 
    690                 695                 700                 


Pro Glu Asp Trp Glu Lys Asn Gln Tyr Phe Leu Met Leu Lys Glu Pro 
705                 710                 715                 720 


Lys Thr Asn Arg Lys Thr Leu Val Gln Gly Trp Lys Asn Gly Phe Asn 
                725                 730                 735     


Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg Lys Trp Phe Met Glu 
            740                 745                 750         


His Trp Lys Ser Ile Lys Val Asp Asp Ser Lys Arg Val Gly Leu Val 
        755                 760                 765             


Ala Lys Val Ile Pro Leu Phe Phe Ser Glu Lys Tyr Lys Asp Ser Val 
    770                 775                 780                 


Gln Pro Phe Tyr Asn Tyr Pro Phe Asn Val Gly Asp Val Asn Lys Pro 
785                 790                 795                 800 


Lys Glu Glu Asp Phe Leu His Arg Lys Asp Arg Ile Glu Leu Trp Asp 
                805                 810                 815     


Lys Lys Lys Val Gly Phe Lys Gly Tyr Lys Ala Lys Glu Lys Pro Lys 
            820                 825                 830         


Glu Met Thr Asp Glu Glu Lys Lys Glu His Arg Ser Tyr Leu Glu Phe 
        835                 840                 845             


Gln Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Val Arg Asn Gln 
    850                 855                 860                 


Asp Ile Val Thr Trp Leu Leu Cys Thr Glu Leu Ile Asp Lys Leu Lys 
865                 870                 875                 880 


Val Glu Gly Leu Asn Val Glu Glu Leu Gln Lys Leu Arg Leu Lys Asp 
                885                 890                 895     


Ile Asn Thr Asp Thr Ala Lys Lys Glu Lys Asn Asn Ile Leu Asn Arg 
            900                 905                 910         


Val Met Pro Met Glu Leu Pro Val Thr Val Tyr Glu Val Asn Lys Ala 
        915                 920                 925             


Ser Asn Ile Ile Lys Asn Lys Pro Leu His Thr Ile Tyr Ile Lys Glu 
    930                 935                 940                 


Ala Lys Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys 
945                 950                 955                 960 


Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Val Asp Thr Ser Ser Lys 
                965                 970                 975     


Ala Glu Ser Glu Ser Asn Thr Ile Ser Lys Ser Arg Val Glu Tyr Glu 
            980                 985                 990         


Leu Gly Glu Tyr Gln Lys Ala Arg  Ile Glu Ile Ile Lys  Asp Met Leu 
        995                 1000                 1005             


Ala Leu  Glu Lys Thr Leu Ile  Asp Lys Tyr Asn Ser  Leu Asp Thr 
    1010                 1015                 1020             


Asp Asn  Phe Asn Lys Met Leu  Thr Asp Trp Leu Glu  Leu Lys Gly 
    1025                 1030                 1035             


Glu Pro  Asp Lys Ala Ser Phe  Gln Asn Asp Val Asp  Leu Leu Ile 
    1040                 1045                 1050             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Arg Asn 
    1055                 1060                 1065             


Arg Ile  Ala Phe Ala Asn Ile  Asn Pro Phe Ser Leu  Ser Ser Ala 
    1070                 1075                 1080             


Asn Thr  Ser Glu Glu Lys Gly  Leu Gly Ile Ala Asn  Gln Leu Lys 
    1085                 1090                 1095             


Asp Lys  Thr Tyr Lys Thr Ile  Glu Lys Ile Ile Glu  Ile Glu Lys 
    1100                 1105                 1110             


Pro Ile  Glu Thr Lys Glu 
    1115                 


<210>  1872
<211>  1319
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1872

Met Gly Lys Glu His Lys Gly Asn Asn Ala Pro Lys Asn Arg Asn Lys 
1               5                   10                  15      


Val Ala Asn Asn Ser Gln Gln Pro Arg Lys Val Arg Arg Leu Gln Lys 
            20                  25                  30          


Thr Asn Phe Arg Ile Ser Leu Ser Gly Lys His Val Phe Gly Ala Tyr 
        35                  40                  45              


Phe Asn Met Ala Arg Thr Asn Phe Ile Lys Thr Ile Asn Tyr Ile Leu 
    50                  55                  60                  


Pro Ile Ala Gly Val Arg Gly Asn Tyr Ser Glu Ser Gln Ile Asn Lys 
65                  70                  75                  80  


Leu Leu Gln Ala Met Phe Leu Ile Gln Thr Gly Arg Asn Gly Glu Leu 
                85                  90                  95      


Thr Lys Glu Gln Lys Gln Trp Glu Lys Lys Leu Arg Leu Asn Pro Glu 
            100                 105                 110         


Gln Gln Thr Lys Leu Gln Gln Leu Leu Phe Lys His Phe Pro Val Leu 
        115                 120                 125             


Gly Pro Met Met Ala Asp Val Ala Asp His Lys Val Tyr Leu Asn Lys 
    130                 135                 140                 


Lys Lys Ser Asn Val Gln Thr Glu Asp Glu Ala Phe Ala Gln Leu Lys 
145                 150                 155                 160 


Gly Val Ser Leu Ala Asp Cys Leu Glu Met Ile Tyr Leu Met Ala Glu 
                165                 170                 175     


Thr Leu Thr Glu Cys Arg Asn Phe Tyr Thr His Lys Ser Pro Tyr Asn 
            180                 185                 190         


Thr Pro Ser Gln Leu Ala Met Gln Tyr Leu His Gln Glu Met Ile Ala 
        195                 200                 205             


Lys Lys Leu Asp Lys Val Val Val Ala Ser Arg Arg Ile Leu Lys Asp 
    210                 215                 220                 


Arg Glu Gly Leu Ser Val Asn Glu Met Glu Phe Leu Thr Gly Ile Asp 
225                 230                 235                 240 


His Leu His Gln Glu Thr Val Lys Asp Glu Tyr Gly Asn Val Lys Met 
                245                 250                 255     


Lys Asp Gly Lys Val Met Lys Thr Phe Val Glu Tyr Asp Asp Phe Tyr 
            260                 265                 270         


Phe Lys Ile Ser Gly Lys Arg Leu Val Lys Gly Phe Thr Val Thr Gly 
        275                 280                 285             


Lys Asp Gly Lys Pro Ile Asn Val Asp Thr Met Leu Pro Ala Leu Ser 
    290                 295                 300                 


Asp Phe Gly Leu Leu Tyr Phe Cys Val Ile Phe Leu Ser Lys Pro Tyr 
305                 310                 315                 320 


Ala Lys Leu Phe Ile Asp Glu Val Arg Leu Phe Glu Phe Ser Pro Phe 
                325                 330                 335     


Ser Asp Asn Glu Asn Met Ile Met Ser Glu Met Leu Ser Ile Tyr Arg 
            340                 345                 350         


Ile Arg Thr Pro Arg Leu His Lys Ile Asp Ser Arg Asp Ser Lys Ala 
        355                 360                 365             


Thr Leu Ala Met Asp Ile Phe Gly Glu Leu Arg Arg Cys Pro Ile Glu 
    370                 375                 380                 


Leu Tyr Asn Leu Leu Asp Lys Asn Ser Gly Gln Pro Phe Phe His Asp 
385                 390                 395                 400 


Glu Val Lys Arg Pro Asn Ser His Thr Pro Glu Val Ser Lys Arg Leu 
                405                 410                 415     


Arg Tyr Asn Asp Arg Phe Pro Thr Leu Ala Leu Arg Tyr Val Asp Glu 
            420                 425                 430         


Thr Glu Leu Phe Lys Arg Ile Arg Phe Gln Leu Gln Leu Gly Ala Phe 
        435                 440                 445             


Arg Tyr Lys Phe Tyr Asp Lys Glu Gly Ile Asp Gly Arg Ile Arg Val 
    450                 455                 460                 


Arg Arg Ile Gln Lys Asp Ile Asn Gly Tyr Gly Arg Leu Gln Glu Val 
465                 470                 475                 480 


Ala Asp Lys Arg Ile Glu Lys Trp Gly Asp Met Leu Gln Lys Arg Glu 
                485                 490                 495     


Glu Arg Ser Val Lys Leu Glu His Glu Glu Leu Tyr Ile Asp Leu Asp 
            500                 505                 510         


Gln Phe Gln Glu Asp Thr Ala Asp Ser Thr Pro Tyr Val Thr Asp Arg 
        515                 520                 525             


Arg Pro Val Tyr Asn Ile His Ala Asn Arg Ile Gly Leu Tyr Trp Glu 
    530                 535                 540                 


Glu Ser Gln Asn Pro Asn Glu Phe Lys Val Phe Asp Asn Asn Gly Met 
545                 550                 555                 560 


Tyr Ile Pro Glu Leu Val Val Thr Glu Asp Glu Lys Ala Pro Val Lys 
                565                 570                 575     


Met Pro Ala Pro Arg Cys Ala Leu Ser Val Tyr Asp Leu Ser Ala Met 
            580                 585                 590         


Leu Phe Tyr Glu Tyr Leu Arg Glu Gln Glu Asp Gly Asn Ile Pro Ser 
        595                 600                 605             


Ala Glu Gln Ile Ile Ile Asp Tyr Glu Ala Asp Tyr Arg Arg Phe Phe 
    610                 615                 620                 


Asn Ala Val Ala Glu Gly Thr Leu Lys Pro Phe Gln Lys Thr Lys Asp 
625                 630                 635                 640 


Phe Arg Glu Tyr Leu Glu Lys Glu Tyr Pro Arg Leu Arg Met Glu Asp 
                645                 650                 655     


Ile Pro Glu Lys Leu Gln Leu Tyr Leu Thr Cys Lys Gly Leu Thr His 
            660                 665                 670         


Asp Asn Lys Pro Glu Thr Val Arg Glu Arg Met Ile Arg Leu Ala Ile 
        675                 680                 685             


Glu His Leu Lys Glu Arg Glu Glu Arg Val Gln Arg Arg Leu Glu His 
    690                 695                 700                 


Tyr Glu Glu Asp Arg Lys Met Ile Gly Glu Lys Asp Asn Lys Tyr Gly 
705                 710                 715                 720 


Lys Lys Gly Phe Ala Asp Val Arg His Gly Ala Ile Ala Arg Tyr Leu 
                725                 730                 735     


Ala Gln Ser Met Met Glu Trp Gln Pro Thr Asn Leu Lys Asp Lys Glu 
            740                 745                 750         


Lys Gly Arg Asp Lys Leu Thr Gly Met Asn Tyr Asn Val Leu Thr Ala 
        755                 760                 765             


Tyr Leu Ala Thr Phe Gly Gln Pro Gln Thr Pro Glu Glu Asp Phe Thr 
    770                 775                 780                 


Pro Arg Thr Leu Glu Gln Val Leu Thr Gly Ala His Leu Ile Gly Gly 
785                 790                 795                 800 


Asn Asn Pro His Pro Phe Ile Asp Lys Val Leu Ala Leu Gly Asn Arg 
                805                 810                 815     


Asn Ile Glu Glu Leu Tyr Leu His Tyr Leu Glu Glu Glu Leu Lys His 
            820                 825                 830         


Ile Arg Ser Arg Lys Gln Ser Leu Ser Ser Asn Pro Ser Asp Lys Asp 
        835                 840                 845             


Leu Ser Ala Leu Pro Phe Val His His Asp His Leu Arg Phe His Glu 
    850                 855                 860                 


Arg Thr Asn Glu Glu Met Arg Ala Leu Ala Ala Arg Tyr Thr Thr Ile 
865                 870                 875                 880 


Gln Leu Pro Asp Gly Leu Phe Thr Pro Tyr Ile Val Glu Leu Leu Lys 
                885                 890                 895     


Gln Tyr Val Glu Leu Gln Thr Ala Leu Asn Gln Asp Ile Pro Ala Asn 
            900                 905                 910         


Leu Asn Pro Thr Asn Asn Ala Ala Tyr Leu Ile Thr Gln Phe Tyr Gln 
        915                 920                 925             


Thr Ile Leu Lys Asp Asp Ala Gln Pro Phe Tyr Ile Ser Gly Lys Thr 
    930                 935                 940                 


Tyr Thr Arg His Lys Glu Gly Glu Lys Asp Glu Val Phe Ser Phe Lys 
945                 950                 955                 960 


Arg Ala Tyr Glu Leu Phe Ser Val Leu Asn Asn Glu Lys Lys Arg Thr 
                965                 970                 975     


Phe Pro Phe Glu Leu Ile Pro Leu Phe Leu Thr Ser Glu Glu Ile Gln 
            980                 985                 990         


Lys Arg Leu Ser Glu Lys Leu Leu  Asp Asp Asp Gly Asn  Thr Met Pro 
        995                 1000                 1005             


Glu Gln  Gly Lys Arg Gly Lys  Ala Ala Thr Asp Ser  Gln Gly Asn 
    1010                 1015                 1020             


Ile Ile  Trp Gln Arg Lys Ile  Lys Leu Asp Ile Ser  Asn Tyr Val 
    1025                 1030                 1035             


Ser Ser  Leu Ser Asp Lys Asp  Leu Lys Ile Ser Met  Asn Gln Ser 
    1040                 1045                 1050             


Trp Lys  Gln Lys Glu Glu Glu  Arg Thr Glu Lys Arg  Glu Ala Leu 
    1055                 1060                 1065             


Gln Ser  Arg Leu Thr Arg Gln  Ile His Asp Ile Lys  Tyr Asn Glu 
    1070                 1075                 1080             


Arg Thr  Leu Arg Arg Tyr Lys  Thr Gln Asp Met Val  Leu Phe Leu 
    1085                 1090                 1095             


Ile Ala  Lys Lys Leu Phe Glu  Asn Ile Ile Phe Glu  Gln Gly Asn 
    1100                 1105                 1110             


Glu Val  Asn Ser Glu Gln Met  Arg Leu Ser Lys Val  Cys Asp Glu 
    1115                 1120                 1125             


Ala Phe  Leu Arg Gln Thr Leu  Thr Phe Arg Val Pro  Val Thr Val 
    1130                 1135                 1140             


Gly Asp  Lys Thr Ile Tyr Val  Glu Gln Glu Asn Met  Ser Leu Lys 
    1145                 1150                 1155             


Asn Tyr  Gly Glu Phe Tyr Arg  Phe Leu Thr Asp Asp  Arg Leu Met 
    1160                 1165                 1170             


Ser Leu  Leu Glu Asn Ile Ile  Gly Thr Leu Lys Pro  Asn Glu Asp 
    1175                 1180                 1185             


Gly Asp  Leu Val Ile Arg His  Thr Asp Leu Met Ser  Glu Leu Ala 
    1190                 1195                 1200             


Ala Tyr  Asp Gln His Arg Ser  Thr Val Phe Lys Leu  Ile Gln Gln 
    1205                 1210                 1215             


Ile Glu  Asn Leu Ile Ile Glu  Lys Asn Ala Ala Leu  Lys Asn Pro 
    1220                 1225                 1230             


Asp Ser  Glu Asp Phe Trp Val  Lys Glu Gly Leu Pro  Lys Arg Asn 
    1235                 1240                 1245             


Asn Phe  Ala Ser Leu Leu Glu  Leu Ile Asp Gln Leu  Asn Asn Val 
    1250                 1255                 1260             


Ala Leu  Thr Asp Glu Glu Arg  Lys Leu Leu Val Ala  Val Arg Asn 
    1265                 1270                 1275             


Ala Phe  Ser His Asn Ser Tyr  Asn Ile Asp Phe Ser  Leu Ile Lys 
    1280                 1285                 1290             


Asp Val  Lys His Leu Pro Glu  Val Ala Lys Gly Ile  Leu Gln His 
    1295                 1300                 1305             


Leu Glu  Ser Val Val Gly Val  Glu Gln Thr Lys 
    1310                 1315                 


<210>  1873
<211>  1403
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1873

Met Gly Lys Asn Lys Gln Lys Lys Lys Ile Gln Ser Gln Asp Ser Ser 
1               5                   10                  15      


Lys Ala Asn Asn Pro Tyr Pro Ser Val Thr Lys Pro Gln Arg Pro Asp 
            20                  25                  30          


Phe Cys Leu Glu Gly Phe Tyr Thr Gln Gln Ala Phe Val Asp Val Arg 
        35                  40                  45              


His Val Ala Ala Asn Tyr Phe Asn Leu Ala His Asn Asn Phe Tyr Lys 
    50                  55                  60                  


Thr Leu Ile Tyr Val Leu Thr Arg Ser Gly Ile Asp Leu Lys Thr Leu 
65                  70                  75                  80  


Asn Phe Trp Asn Phe Lys Asp Asp Ser Ile Gly Thr Val Leu Gln Thr 
                85                  90                  95      


Val Cys Asp Ala Thr Phe Gly Ser Gly Glu Gln Lys Gln Ala Ile Lys 
            100                 105                 110         


Asp Tyr Tyr Phe Ser Ile Glu Glu Lys Lys Leu Ile Val Glu Asn Asn 
        115                 120                 125             


Lys Glu Asn Asp Ser Asn Lys Lys Lys Ser Asp Ala Glu Ile Arg Glu 
    130                 135                 140                 


Leu Ser Leu Gln Arg Ala Glu Lys Asp Phe Gly Ser Phe Val Leu Phe 
145                 150                 155                 160 


Glu Asp Met Gln Gly Arg Ile Gln Lys Lys Leu Phe His His Ile Pro 
                165                 170                 175     


Ala Phe Gly Pro Ile Met Ala Asp Val Ala Ser Tyr Glu Ala Tyr Lys 
            180                 185                 190         


Asn Arg Gln Lys Ser Asp Glu Leu Lys Asp Lys Asn Lys Glu Lys Ile 
        195                 200                 205             


Leu Arg Gly Ile Thr Phe Gln Gln Cys Leu Glu Thr Leu Ile Ile Ile 
    210                 215                 220                 


Ala Asn Ala Leu Asn Tyr Tyr Arg Asn Phe Tyr Thr His Glu Ile Pro 
225                 230                 235                 240 


Tyr Asn Glu Leu Glu Glu Glu Trp Ser Gln Thr Leu Arg Glu Ala Lys 
                245                 250                 255     


Leu Val Lys Tyr Met Asn Asn Val Phe Lys Ala Ser Gln Arg Leu Asp 
            260                 265                 270         


Lys Lys Arg Glu Leu Val Thr Thr Glu Ala Met Thr Phe Leu Thr Gly 
        275                 280                 285             


His Gly Ser Gly Asp Pro Cys Asp Arg Met Lys Glu Ile Pro Asn Gly 
    290                 295                 300                 


Glu Lys Thr Tyr Phe Asp Glu Lys Lys His Arg Asn Val Thr Ile Lys 
305                 310                 315                 320 


Val Tyr Arg Tyr Glu Glu Asn Glu Asn Phe Phe Phe Lys Ile Ala Gly 
                325                 330                 335     


Arg Glu Phe Thr Thr Glu Asp Gly Gly Lys Ala Asn Tyr Leu Ser Asp 
            340                 345                 350         


Phe Gly Lys Leu Leu Phe Cys Cys Leu Phe Leu Lys Arg Gln Gln Thr 
        355                 360                 365             


Gln Asn Phe Ala Ile Glu Ser Arg Leu Leu Glu Phe Ser Pro Tyr Leu 
    370                 375                 380                 


Leu Lys Pro His Glu Leu Gln Lys Lys Gln Ala Glu Glu Asn Lys Arg 
385                 390                 395                 400 


Val Asp Lys Glu Asn Lys Leu Arg Gln Ala Gln Gly Lys Lys Arg Met 
                405                 410                 415     


Leu Thr Pro Lys Gln Phe Thr Lys His Asp Ser Leu Gln Asn Glu Ile 
            420                 425                 430         


Ile Leu Asp Met Leu Gly Ile Tyr His Ile Arg Arg Pro Leu Glu Lys 
        435                 440                 445             


Arg Ile Asp Ala Lys Ala Thr Pro Gly Thr Leu Ala Met Asp Met Leu 
    450                 455                 460                 


Asn Glu Leu Arg Arg Cys Pro Ser Glu Leu Tyr Gln Thr Phe Ser Ala 
465                 470                 475                 480 


Asp Asp Lys Asp Ile Phe Glu Arg Glu Val Ser Asp Pro Lys Asp Gly 
                485                 490                 495     


Ser Pro Arg Ser Ala Lys Ala Glu Glu Lys Val Lys Leu Ile Arg Tyr 
            500                 505                 510         


Thr Asp Arg Phe Pro Tyr Leu Ala Leu Arg Tyr Ile Asp Glu Thr Asn 
        515                 520                 525             


Leu Ile Gly Asp Ile Arg Phe His Ile Arg Leu Gly Asn Tyr Arg Phe 
    530                 535                 540                 


His Phe Tyr Asp Lys Thr Cys Val Asp Gly Asn Pro Lys Ile Arg Ser 
545                 550                 555                 560 


Trp Gln Lys Glu Ile Asn Gly Phe Gly Lys Trp Gln Glu Ile Glu Glu 
                565                 570                 575     


Lys Arg Lys Ser Lys Trp Ala Asn Gln Phe Gln Lys Arg Glu Tyr Val 
            580                 585                 590         


Asn Thr Arg Gln Glu Tyr Gly Glu Met Glu Leu Glu Gln Pro Val Lys 
        595                 600                 605             


Asp His Ala Asp Thr Lys Pro Tyr Ile Thr Asp Trp Thr Ala Ala Tyr 
    610                 615                 620                 


Asn Ile His Ala Asn Arg Ile Gly Leu Tyr Trp Gly Leu Glu Asp Gly 
625                 630                 635                 640 


Met Phe Leu Pro Asp Leu Asn Thr Ile Val Asp Pro Thr Asp Ala Asn 
                645                 650                 655     


Ala Ser Gln Glu Glu Leu Arg Lys Ser Glu Met Lys Pro Arg His Arg 
            660                 665                 670         


Ala Pro Val Ile Met Lys Glu Pro Leu Cys Thr Leu Ser Thr Tyr Asp 
        675                 680                 685             


Leu Pro Ala Leu Leu Phe Tyr Asn Tyr Leu Phe Lys His Tyr Asn Ala 
    690                 695                 700                 


Ala Lys Tyr Lys Met Pro Met Pro Asn Lys Ile Ile Lys Asp Ala Tyr 
705                 710                 715                 720 


Asp Gly Leu Lys Ala Phe Ile Asp Ala Ile Ala Ala Arg Lys Lys Gly 
                725                 730                 735     


Lys Asp Leu Glu Glu Val Leu Gln Gln Lys Gly Val Arg Glu Phe Asp 
            740                 745                 750         


Ile Pro Lys Ala Leu Arg Lys Arg Leu Glu Ser Gln Gly Lys Pro Glu 
        755                 760                 765             


Gln Phe Asn Asn Lys Ile Tyr Met Arg Leu Val Glu Arg Val Tyr Gly 
    770                 775                 780                 


Arg Tyr Asp Ile Glu Arg Glu Met Tyr Val Pro Gly Lys Leu Ser Glu 
785                 790                 795                 800 


Lys Leu Glu Glu Ile Glu Tyr Arg Ile Lys Ala Phe Lys Asp Lys Lys 
                805                 810                 815     


Ala Lys Ile Asp Ser Gly Asp Asn Lys Tyr Ala Lys Lys Gly Tyr Ala 
            820                 825                 830         


Asp Ile Arg His Gly Val Leu Ala Arg Tyr Leu Ala Lys Ser Phe Met 
        835                 840                 845             


Gln Trp Gln Pro Thr Lys Asp Lys Gly His Asp Lys Ile Thr Gly Leu 
    850                 855                 860                 


Asn Tyr Ser Val Met Thr Ala Phe Leu Ser Thr Tyr Gly Ile Asn Ser 
865                 870                 875                 880 


Asp Ile Val Gln Leu Arg Thr Leu Leu Glu Lys Ala Lys Leu Ile Gly 
                885                 890                 895     


Ser Ala Asn Pro His Pro Phe Leu Pro Glu Val Leu Ala Glu Ser Pro 
            900                 905                 910         


Gln Asn Ile Glu Asp Leu Tyr Phe Ile Tyr Leu Lys Gln Glu Gln Lys 
        915                 920                 925             


Phe Ala Glu Gly Leu Asn Ser His His Gly Lys Leu Lys Ala Phe Lys 
    930                 935                 940                 


Gly Asn Leu Gln Asp Lys Ile Lys Tyr Ile Asn Glu Asn Lys Ser Ser 
945                 950                 955                 960 


Ile Asp Gln Ile Leu Ala Gln Ile Pro Phe Val His Ala Asp Arg Glu 
                965                 970                 975     


Lys Trp Arg Arg Thr Asp Ser Val Asp Lys Tyr Tyr Thr Asp Tyr Ala 
            980                 985                 990         


Gly Arg Tyr His Thr Ile Met Leu  Pro Asp Ser Leu Phe  Thr Pro Tyr 
        995                 1000                 1005             


Ile Ile  Arg Leu Met Lys Ser  Cys Leu Pro Asn Asp  Lys Thr Leu 
    1010                 1015                 1020             


Met Ser  Arg Ile Lys Ala Cys  Glu Ser Asp Ser Arg  Gln Thr Leu 
    1025                 1030                 1035             


Gly Ala  Ala Trp Leu Ile Glu  Tyr Tyr Phe Glu His  His Met Lys 
    1040                 1045                 1050             


Asp Lys  His Gln Gln Phe Tyr  Asn Ala Asn Ile Phe  Arg Arg Ala 
    1055                 1060                 1065             


Tyr Lys  Pro Phe Thr Thr Met  Asn Asn Asp Phe Val  Lys Asn Gln 
    1070                 1075                 1080             


Asn Gly  Gly Asn Thr Asn Glu  Pro Leu Pro Tyr Tyr  Asn Ser Lys 
    1085                 1090                 1095             


Lys Glu  Ile Glu Glu Lys Leu  Ser Tyr Thr Glu Glu  Asp Ile Arg 
    1100                 1105                 1110             


Asn Phe  Val Tyr Asn Val Trp  Arg Gly Lys Thr Lys  Arg Glu Glu 
    1115                 1120                 1125             


Ile Glu  Ile Leu Lys Asn Gln  Ile Lys Asp Val Lys  Asp Thr Glu 
    1130                 1135                 1140             


Lys Val  Ile Arg Arg Tyr Arg  Thr Gln Asp Val Thr  Leu Phe Leu 
    1145                 1150                 1155             


Ala Ala  Lys Asp Leu Leu Thr  Thr Gln Leu Ser Lys  Asp Asp Asn 
    1160                 1165                 1170             


Met Ala  Asp Ala Thr Lys Gln  Ala Met Lys Asn Leu  Lys Glu Lys 
    1175                 1180                 1185             


Ala Glu  Cys Leu Lys Leu Lys  Asp Phe Asp Tyr Asp  Glu Gly Phe 
    1190                 1195                 1200             


Ser Phe  Leu Ser Asp Gly Asp  Asn Pro Glu Ser Gly  Ile Val Tyr 
    1205                 1210                 1215             


Thr Tyr  Glu Tyr Lys Thr Lys  Thr Gly Arg Thr Val  Lys Ile Thr 
    1220                 1225                 1230             


Gln Lys  Gly Val Ser Leu Lys  Asn Tyr Gly Asn Ile  Tyr Arg Ile 
    1235                 1240                 1245             


Leu Gly  Asp Asp Arg Phe Lys  Ser Leu Met Glu Gly  Ile Ala Asn 
    1250                 1255                 1260             


Ile Ala  Thr Thr Asp Ser Ile  Glu Val Thr Phe Asn  Asp Leu Thr 
    1265                 1270                 1275             


Thr Glu  Phe Ala Asn Tyr Asp  Glu Arg Arg Ser Ala  Met Phe Lys 
    1280                 1285                 1290             


Met Val  His Glu Leu Glu Gly  Lys Ala Phe Ile Arg  Asn Glu Lys 
    1295                 1300                 1305             


Glu Leu  Gln Asp Pro Asn Asn  Pro Val Phe His Ile  Lys Asn Asp 
    1310                 1315                 1320             


Leu Ala  Lys Asp Pro Arg Arg  Asn Asn Phe Ser Ser  Leu Leu Glu 
    1325                 1330                 1335             


Leu Leu  Gln Glu Tyr Ser Asp  Lys Asp Gln Lys Val  Met Val Ala 
    1340                 1345                 1350             


Ile Arg  Asn Ala Ile Gly His  Asp Tyr Tyr Met Asp  Ile Thr Leu 
    1355                 1360                 1365             


Leu Asp  Arg Thr Asn Ser Lys  Ala Lys Arg Val Pro  Asn Ile Ser 
    1370                 1375                 1380             


Leu Leu  Met Glu His Thr Leu  Asn Lys Lys Lys Asp  Asn Pro Ser 
    1385                 1390                 1395             


Gln Asp  Lys Lys Lys 
    1400             


<210>  1874
<211>  1220
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1874

Met Ser Thr Arg Tyr Thr Asn Gln Lys Lys Val Glu Glu Asn Ile Asn 
1               5                   10                  15      


Tyr Val Phe Ser Asn Lys Gly Ile Phe Ala Ala Val Ala Glu Lys Thr 
            20                  25                  30          


Leu Thr Asn Tyr Lys Ser Lys Phe Asn Glu Gly Gln Thr Ile Gln Pro 
        35                  40                  45              


Asn Leu His Tyr Phe Ala Val Gly His Thr Phe Lys Asn Ile Asp Thr 
    50                  55                  60                  


Lys Arg Ile Phe Asp Tyr Gln Leu Ser Glu Asp Glu Met Asp Ile Leu 
65                  70                  75                  80  


Pro Thr Lys Tyr Phe Ser Leu Gln Gln Asn Lys Phe Ser Phe Pro Ile 
                85                  90                  95      


Asp Gly Gln Thr Lys Thr Asp Lys Leu Tyr Leu Leu Leu Asp Asn Ile 
            100                 105                 110         


Arg Asn Ile Asn Ala His Phe Ile His Asp Phe Asn Phe Leu Lys Val 
        115                 120                 125             


Asp Asn Ile Asp Glu Asn Ile Ile Cys Phe Leu Ile Asp Ser Phe Glu 
    130                 135                 140                 


Leu Ala Leu Ile Lys Gly Val Phe Ala Lys Lys Tyr Gly Asn Lys Lys 
145                 150                 155                 160 


His Glu Leu Gly Leu Asp Phe Leu Ser Asn Asp Leu Lys Asp Glu Ile 
                165                 170                 175     


Leu Glu Glu Ile Leu Glu Asn Leu Asp Asp Glu Leu Ile Val Phe Met 
            180                 185                 190         


Lys Glu Ile Phe Tyr Gln Thr Leu Tyr Val Val Asp Lys Lys Glu Trp 
        195                 200                 205             


Arg Asn Lys Glu Leu Asn Gln Glu Lys Lys Asp Phe Leu Asp Ser His 
    210                 215                 220                 


Leu Ser Ser Lys Glu Asp Trp Ile Asn Trp Ile Leu Phe Asn Cys Val 
225                 230                 235                 240 


Glu Glu Asp Ile Asp Trp Phe Leu Asn Asn Tyr Gly Asp Ser Asp Pro 
                245                 250                 255     


His Pro Asp Ser Lys Asn His Lys His Lys Val Leu Thr Ile Glu Lys 
            260                 265                 270         


Gly Lys His Leu Ser Phe Glu Gly Ser Leu Phe Met Met Thr Met Phe 
        275                 280                 285             


Leu Tyr Ala Asn Glu Ala Asn Tyr Leu Ile Pro Lys Leu Lys Gly Tyr 
    290                 295                 300                 


Lys Lys Asn Gly Thr Pro Gln Asp Ala Ser Lys Leu Glu Val Phe Arg 
305                 310                 315                 320 


Phe Phe Ala Lys Lys Phe Lys Ser Gln Asp Val Asp Ser Glu His Lys 
                325                 330                 335     


Gln Tyr Val Lys Phe Arg Asp Met Ile Gln Tyr Val Gly Lys Tyr Pro 
            340                 345                 350         


Thr Val Trp Asn Lys His Ile His Leu Asp Asn Tyr Tyr Val Asn Glu 
        355                 360                 365             


Leu Lys Val Ser Ile Leu Glu Asn Glu Ile Thr Gln Leu Phe Glu Gln 
    370                 375                 380                 


Asp Ile Gln Asn Tyr Phe Glu Thr Lys Tyr Gly Leu Gln Lys Phe Ala 
385                 390                 395                 400 


Lys Ala Lys Gly Asp Met His Tyr Ala Phe Val Glu Val Ala Lys Ser 
                405                 410                 415     


Tyr Leu Gln Lys Lys Thr Ile Ser Tyr Lys Gly Lys Tyr Gln Asp Asp 
            420                 425                 430         


Ser Ile Ala Ile Leu Glu Thr Leu Ala Glu Gln Ile Thr Asn Lys Arg 
        435                 440                 445             


Gln Leu Lys Asn Ile Glu Val Lys Leu Leu Arg Phe Ser Asp Thr Asp 
    450                 455                 460                 


Tyr Gln Ser Leu Ser Ser Ile Glu Lys Thr Lys Lys Gln Arg Leu Asp 
465                 470                 475                 480 


Lys Ser Lys Lys Met Phe Leu Asp Lys Ile Lys Glu Ser Lys Lys Thr 
                485                 490                 495     


Ile Asn Lys Thr Thr Glu Lys Phe Ala Lys Arg Val Glu Asp Asn Leu 
            500                 505                 510         


Leu Tyr Ile Ser Asn Gly Arg Asn Ser Asp Arg Phe Met Val Phe Ala 
        515                 520                 525             


Cys Arg Phe Leu Ala Glu Ile Asn Tyr Phe Gly Lys Asp Ala Gln Phe 
    530                 535                 540                 


Lys Met Tyr Glu Asn Tyr Tyr Ser Glu Glu Glu Gln Asn Ala Leu Lys 
545                 550                 555                 560 


Asp Lys Lys Gln Asn Leu Thr Gln Lys Asp Phe Asp Lys Leu His Tyr 
                565                 570                 575     


His Trp Gly Lys Leu Thr His Phe Glu Thr Phe Glu Asn His Val Lys 
            580                 585                 590         


Lys Tyr Pro Asn Trp Asp Met Pro Phe Val Val Gln Asn Asn Ala Ile 
        595                 600                 605             


Tyr Val Lys Ile Pro Gly Ile Asn Phe Ile Lys Asn Thr Ala Phe Cys 
    610                 615                 620                 


Ile Arg Arg Asn Val Ile Asn Tyr Leu Leu Glu His Ala Leu Gly Glu 
625                 630                 635                 640 


Asn Tyr Lys Asp Gln Gln Gly Arg Glu Trp Leu Phe Asp Tyr Tyr Glu 
                645                 650                 655     


Tyr Lys Thr Glu Ala Thr Asp Asn Ala Lys Arg Ile Leu Thr Glu Ser 
            660                 665                 670         


Lys Pro Ile Glu Ala Ser Ser Lys Thr Gln Leu Lys Lys Leu Leu Pro 
        675                 680                 685             


Lys Lys Leu Leu Pro Lys His Ser Pro Leu Glu Thr Glu Asn Lys Glu 
    690                 695                 700                 


Asn Ile Phe Arg Lys Tyr Leu Glu Gln Ala Glu Glu Ser Glu Lys Leu 
705                 710                 715                 720 


Tyr Glu Asn Gln Lys Asp Lys Ala Lys Ala Glu Lys Lys Leu Asp Leu 
                725                 730                 735     


Phe Val Asn Lys Asn Lys Gly Lys Gln Phe Lys Leu Arg Phe Ile Phe 
            740                 745                 750         


Lys Ala Trp Gln Leu Met Tyr Phe Lys Lys Gln Tyr Gln Ile Glu Lys 
        755                 760                 765             


Glu Arg Tyr Ala Glu Leu Glu Lys Leu Asp Gly Ile Pro Lys Asn Tyr 
    770                 775                 780                 


Glu His Glu Phe Gly His His Lys Lys Phe Asn Ile Asn Arg Lys Glu 
785                 790                 795                 800 


Phe Asn Leu Phe Ser Lys Trp Leu Phe Ala Met Asp Glu Val Pro Glu 
                805                 810                 815     


Tyr Lys Asn Ser Leu Lys Glu Leu Leu Asp Asp Lys Asn Phe Phe Val 
            820                 825                 830         


Asn Ser Glu Phe Gln Lys Leu Phe Glu Ser Ser Ser Asn Ile Asn Gln 
        835                 840                 845             


Phe Tyr Glu Ser Thr Lys Ser Lys Phe Lys Asn Trp Leu Asn Asp Gln 
    850                 855                 860                 


Gln Val Gln Asn Ile Arg Lys Thr Ile Gln Pro Glu Asn Tyr Tyr Lys 
865                 870                 875                 880 


Met Met Glu Val Gly Asn Phe His Ile Asn Leu Ser His Phe Ile Ala 
                885                 890                 895     


Phe Gly Val Ser His Asp Phe Ile Glu Lys Ser Gly Lys Asn Ile Leu 
            900                 905                 910         


Arg Pro Ile Thr Ser His Ala Lys Tyr Leu Asn Thr Lys Ile Tyr Asp 
        915                 920                 925             


Ile Asp Leu Glu His Ser Asp Ala Ser Asn Leu Glu Lys Asn Ile Phe 
    930                 935                 940                 


Arg Lys Leu Tyr Lys Ile Arg Leu Glu Asp Cys Leu Leu Tyr Glu Ile 
945                 950                 955                 960 


Ala Leu Arg Tyr Phe Gln Pro Asn Leu Asn Leu Arg Gln Lys Ser Tyr 
                965                 970                 975     


Glu Gln Leu Asn Lys Leu Leu Val Gln Lys Ile Ser Ile Ala Ile Lys 
            980                 985                 990         


Ala Asn Asn Ser Gln Thr Tyr Gln  Val Leu Val Pro Phe  Lys Asp Leu 
        995                 1000                 1005             


Glu Lys  Phe Ala Gln Leu Lys  Ala Ile Asp Asp Asn  Thr Gln Asn 
    1010                 1015                 1020             


Lys Phe  Ser Leu Leu Arg Arg  Leu Pro Glu Tyr Leu  Ser Gln Val 
    1025                 1030                 1035             


Asn Glu  Arg Asn Glu Asn Val  Ser Gly Leu Lys Asp  Met Val Glu 
    1040                 1045                 1050             


Ala Phe  Gly Val Asp Lys Ser  Ile Ser Leu Ala Asp  Met Ser Met 
    1055                 1060                 1065             


Leu Tyr  Asn His Leu Ile Thr  Gln Gln Gly Arg Tyr  Thr Asn Cys 
    1070                 1075                 1080             


Ile Met  Ala Leu Glu Glu Tyr  Phe Ile Trp Lys Glu  Lys Phe Thr 
    1085                 1090                 1095             


Ile Glu  Lys Gln Glu Ser Lys  Lys Phe Lys Asn Arg  Ile Val Val 
    1100                 1105                 1110             


Thr Glu  Ile Pro Val Leu Lys  Asp Tyr Phe Lys Arg  Asp Glu Gln 
    1115                 1120                 1125             


Arg Asn  Asn Ala Phe His Met  Asp Leu Pro Ile Asn  Glu Thr Tyr 
    1130                 1135                 1140             


Lys Ser  Thr Phe Lys Ala Ile  Glu Lys Gln Phe Val  Ala Thr Glu 
    1145                 1150                 1155             


Val Asp  Lys Ala Tyr Thr Lys  Leu Asp Asp Cys Pro  Ser Met Leu 
    1160                 1165                 1170             


Lys Asn  Thr Leu Lys Val Phe  Met Asn Gln Met His  Asp Glu Ile 
    1175                 1180                 1185             


Lys Leu  Gly Tyr Lys Pro Asn  Asp Thr Lys Asp Gly  Ile Lys Gln 
    1190                 1195                 1200             


Lys Arg  Thr Val Ala Glu Asn  Thr Phe Phe Lys Gln  Leu Leu Lys 
    1205                 1210                 1215             


Gly Tyr  
    1220 


<210>  1875
<211>  1146
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1875

Met Glu Ser Ile Ile Gly Leu Gly Leu Ser Phe Asn Pro Tyr Lys Thr 
1               5                   10                  15      


Ala Asp Lys His Tyr Phe Gly Ser Phe Leu Asn Leu Ala Asp Asn Asn 
            20                  25                  30          


Leu Lys Ala Val Phe Ala Glu Phe Lys Glu Arg Ile Ser Asp Lys Ser 
        35                  40                  45              


Lys Asp Glu Asp Ile Ser Asn Leu Ile Glu Lys His Phe Ile Asp Asn 
    50                  55                  60                  


Met Ser Ile Val Asp Tyr Glu Lys Asn Ile Ser Ile Leu Asn Gly Tyr 
65                  70                  75                  80  


Leu Pro Ile Ile Asp Phe Leu Asp Asp Glu Leu Glu Asn Asn Leu Asn 
                85                  90                  95      


Thr Arg Val Lys Asn Phe Lys Lys Ser Phe Ile Ile Leu Ala Glu Ala 
            100                 105                 110         


Leu Glu Thr Leu Arg Asn Tyr Tyr Thr His Phe Tyr His Asp Pro Ile 
        115                 120                 125             


Thr Phe Gly Asp Asn Lys Glu Pro Leu Leu Glu Leu Leu Asp Glu Val 
    130                 135                 140                 


Leu Leu Lys Thr Ile Leu Asp Val Lys Lys Lys Tyr Leu Lys Thr Asp 
145                 150                 155                 160 


Lys Thr Lys Glu Ile Leu Lys Asp Ser Leu Arg Glu Glu Met Asp Leu 
                165                 170                 175     


Leu Val Ile Arg Lys Thr Asp Glu Leu Arg Glu Lys Lys Lys Thr Asn 
            180                 185                 190         


Pro Lys Phe Lys Phe Ser Thr Asp Pro Thr Gln Ile Arg Asn Ser Ile 
        195                 200                 205             


Phe Asn Asp Ala Phe Gln Gly Leu Leu Tyr Glu Asp Lys Glu Asn Asn 
    210                 215                 220                 


Gly Lys Thr Gln Val Ser Tyr Arg Ala Lys Thr Lys Leu Asn Pro Lys 
225                 230                 235                 240 


Asp Ile His Lys Gln Glu Glu Arg Asp Phe Glu Ile Pro Leu Ser Thr 
                245                 250                 255     


Ser Gly Ile Val Phe Leu Met Ser Leu Phe Leu Ser Lys Lys Glu Ile 
            260                 265                 270         


Glu Asp Phe Lys Ser Asn Ile Lys Gly Phe Lys Gly Lys Val Val Lys 
        275                 280                 285             


Asp Glu Asn His Asn Ser Leu Lys Tyr Met Ala Thr His Arg Val Tyr 
    290                 295                 300                 


Ser Ile Leu Ala Phe Lys Gly Leu Lys Tyr Arg Ile Lys Thr Asp Thr 
305                 310                 315                 320 


Phe Ser Lys Val Thr Leu Met Met Gln Met Ile Asp Glu Leu Ser Lys 
                325                 330                 335     


Val Pro Asp Cys Val Tyr Gln Asn Leu Ser Glu Thr Lys Gln Lys Asp 
            340                 345                 350         


Phe Ile Glu Asp Trp Asn Glu Tyr Leu Lys Asp Asn Glu Glu Asn Thr 
        355                 360                 365             


Glu Asn Leu Glu Asn Ser Arg Val Val His Pro Leu Ile Arg Lys Arg 
    370                 375                 380                 


Tyr Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe 
385                 390                 395                 400 


Ala Asn Phe Lys Thr Leu Lys Phe Gln Val Phe Met Gly Tyr Tyr Ile 
                405                 410                 415     


His Asp Gln Arg Thr Lys Thr Ile Gly Thr Thr Asn Ile Thr Thr Glu 
            420                 425                 430         


Arg Thr Val Lys Glu Lys Ile Asn Val Phe Gly Lys Leu Ser Lys Met 
        435                 440                 445             


Asp Asn Leu Lys Lys His Phe Phe Ser Gln Leu Ser Asp Glu Glu Asn 
    450                 455                 460                 


Thr Asp Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Phe Leu Thr Gln 
465                 470                 475                 480 


Ala Asp Asn Ser Pro Ala Asn Asn Ile Pro Ile Tyr Leu Glu Leu Lys 
                485                 490                 495     


Asn Gln Gln Ile Ile Lys Glu Lys Asp Asp Ile Lys Ala Glu Val Asn 
            500                 505                 510         


Asn Ser Gln Asn Arg Asn Pro Asn Lys Pro Ser Lys Arg Asp Leu Leu 
        515                 520                 525             


Asn Lys Ile Ser Asn Thr Asn Glu Asp Phe Tyr Gln Gly Asp Pro Thr 
    530                 535                 540                 


Ala Ile Leu Ser Leu Asn Glu Ile Pro Ala Leu Leu His Leu Phe Leu 
545                 550                 555                 560 


Val Gln Pro Asp Asn Lys Thr Gly Gln Gln Ile Glu Asn Ile Ile Arg 
                565                 570                 575     


Ile Lys Ile Glu Lys Gln Phe Asn Ser Ile Lys Asn Pro Ser Lys Asp 
            580                 585                 590         


Asp Lys Gly Val Pro Lys Ser Leu Phe Ala Asp Thr Asn Val Arg Val 
        595                 600                 605             


Asn Ala Ile Lys Leu Lys Lys Asp Leu Gly Glu Glu Leu Asp Met Leu 
    610                 615                 620                 


Asn Lys Lys Gln Ile Val Phe Lys Glu Asn Gln Lys Ala Ser Ser Asn 
625                 630                 635                 640 


Tyr Asp Glu Leu Leu Lys Lys His Gln Phe Thr Pro Lys Asn Lys Arg 
                645                 650                 655     


Pro Ala Leu Arg Lys Tyr Val Phe Tyr Asn Ser Glu Lys Gly Glu Glu 
            660                 665                 670         


Ala Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Lys Gly Phe 
        675                 680                 685             


Lys Thr Lys Trp Lys Gly Tyr Gln His Ser Glu Leu Gln Arg Lys Leu 
    690                 695                 700                 


Ala Phe Tyr Asp Arg His Thr Lys Gln Asp Ile Lys Glu Leu Leu Ser 
705                 710                 715                 720 


Gly Cys Glu Phe Asp His Phe Leu Leu Asp Ile Asn Ala Cys Phe Lys 
                725                 730                 735     


Glu Asp Asp Phe Glu Asp Phe Phe Ser Lys Tyr Leu Lys Asn Arg Ile 
            740                 745                 750         


Glu Thr Leu Asn Ile Ile Leu Lys Gln Leu His Asp Phe Lys Asn Glu 
        755                 760                 765             


Pro Thr Pro Leu Lys Gly Val Phe Lys Asn Cys Leu Lys Phe Leu Lys 
    770                 775                 780                 


Gln Lys Asn Tyr Val Thr Glu Asn Pro Glu Ile Ile Lys Lys Arg Ile 
785                 790                 795                 800 


Leu Ala Lys Pro Ala Phe Leu Pro Arg Gly Ile Phe Asp Glu Arg Pro 
                805                 810                 815     


Thr Met Lys Lys Gly Lys Asn Pro Leu Ile Asp Arg Asp Glu Phe Ala 
            820                 825                 830         


Lys Trp Phe Val Glu Tyr Leu Glu Asn Lys Asp Tyr Gln Lys Phe Tyr 
        835                 840                 845             


Asn Ser Glu Glu Tyr Arg Ile Arg Asp Ala Asp Phe Lys Lys Asn Ala 
    850                 855                 860                 


Val Ile Lys Lys Gln Lys Leu Lys Asp Phe Tyr Thr Leu Gln Met Val 
865                 870                 875                 880 


Asn Tyr Leu Leu Lys Glu Val Phe Gly Lys Asp Glu Met Asn Leu Gln 
                885                 890                 895     


Leu Ser Glu Leu Phe Gln Thr Arg Gln Glu Arg Leu Lys Leu Gln Gly 
            900                 905                 910         


Ile Ala Lys Lys Gln Met Asn Lys Glu Thr Gly Asp Ser Ser Glu Asn 
        915                 920                 925             


Thr Arg Asn Gln Thr Tyr Ile Trp Asn Lys Asp Val Pro Val Ser Phe 
    930                 935                 940                 


Phe Asn Gly Lys Val Thr Ile Asp Lys Val Lys Leu Lys Asn Ile Gly 
945                 950                 955                 960 


Lys Tyr Lys Arg Tyr Glu Arg Asp Glu Arg Val Lys Thr Phe Ile Gly 
                965                 970                 975     


Tyr Glu Val Asp Glu Lys Trp Met Met Tyr Leu Pro His Asn Trp Lys 
            980                 985                 990         


Asp Arg Tyr Ser Val Lys Pro Ile  Asn Val Ile Asp Leu  Gln Ile Gln 
        995                 1000                 1005             


Glu Tyr  Glu Glu Ile Arg Ser  His Glu Leu Leu Lys  Glu Ile Gln 
    1010                 1015                 1020             


Asn Leu  Glu Gln Tyr Ile Tyr  Asp His Thr Thr Asp  Lys Asn Thr 
    1025                 1030                 1035             


Leu Leu  Gln Asp Gly Asn Pro  Asn Phe Lys Met Tyr  Val Leu Asn 
    1040                 1045                 1050             


Gly Leu  Leu Thr Gly Ile Lys  Gln Val Asn Ile Ala  Asp Phe Ile 
    1055                 1060                 1065             


Val Leu  Lys Gln Asn Thr Asn  Phe Asp Lys Ile Asp  Phe Thr Gly 
    1070                 1075                 1080             


Ile Ala  Ser Cys Ser Glu Leu  Glu Lys Lys Thr Ile  Ile Leu Ile 
    1085                 1090                 1095             


Ala Ile  Arg Asn Lys Phe Ala  His Asn Gln Leu Pro  Asn Lys Thr 
    1100                 1105                 1110             


Ile Tyr  Asp Leu Ala Asn Glu  Phe Leu Lys Lys Glu  Lys Arg Glu 
    1115                 1120                 1125             


Thr Tyr  Ala Asn Tyr Tyr Leu  Lys Val Leu Lys Lys  Met Ile Ser 
    1130                 1135                 1140             


Asp Leu  Ala 
    1145     


<210>  1876
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1876

Leu Gln Lys Gln Asp Lys Leu Phe Val Asp Arg Lys Lys Asn Ala Ile 
1               5                   10                  15      


Phe Ala Phe Pro Lys Tyr Ile Thr Ile Met Glu Asn Lys Glu Lys Thr 
            20                  25                  30          


Glu Pro Ile Tyr Tyr Glu Leu Thr Asp Lys His Phe Trp Ala Ala Phe 
        35                  40                  45              


Leu Asn Leu Ala Arg His Asn Val Tyr Thr Thr Val Asn His Ile Asn 
    50                  55                  60                  


Lys Leu Leu Glu Ile Ala Glu Leu Lys Asn Asp Glu Asp Val Leu Asn 
65                  70                  75                  80  


Ile Lys Asp Ser Trp Asn Lys Gln Ala Glu Lys Leu Asp Lys Lys Val 
                85                  90                  95      


Arg Leu Arg Asn Leu Leu Met Arg His Phe Pro Phe Leu Glu Ala Ala 
            100                 105                 110         


Ala Tyr Glu Lys Thr Thr Ser Lys Asp Ser Asn Ser Lys Glu Gln Lys 
        115                 120                 125             


Glu Lys Glu Gln Ala Glu Ala Leu Ser Leu Asp Asn Leu Lys Asn Val 
    130                 135                 140                 


Leu Phe Ile Phe Leu Glu Lys Leu Gln Ser Leu Arg Asn Tyr Tyr Ser 
145                 150                 155                 160 


His Tyr Lys Tyr Ser Glu Glu Ala Gln Lys Pro Thr Phe Glu Asn Asp 
                165                 170                 175     


Leu Leu Lys Asn Met Tyr Lys Ile Phe Asp Thr Asn Val Arg Leu Val 
            180                 185                 190         


Lys Arg Asp Tyr Met His His Glu Asn Val Asp Met Gln Arg Asp Phe 
        195                 200                 205             


Ser His Leu Asn Arg Lys Lys Gln Glu Gly Gln Thr Arg Lys Ile Ile 
    210                 215                 220                 


Ala Asn Pro Asn Phe Arg Tyr His Phe Ala Asp Glu Lys Gly Asp Met 
225                 230                 235                 240 


Thr Ile Ala Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Asp Lys Lys 
                245                 250                 255     


Asp Ala Ile Trp Met Gln Lys Lys Leu Lys Gly Phe Lys Asp Gly Arg 
            260                 265                 270         


Asn Leu Arg Glu Gln Met Thr Asn Glu Val Phe Cys Arg Ser Arg Ile 
        275                 280                 285             


Ser Leu Pro Lys Leu Lys Leu Glu Asn Val Gln Thr Lys Asp Trp Met 
    290                 295                 300                 


Gln Leu Asp Met Leu Asn Glu Leu Val Arg Cys Pro Lys Ser Leu Tyr 
305                 310                 315                 320 


Glu Arg Leu Arg Glu Lys Asp Arg Glu Ser Phe Lys Val Pro Phe Asp 
                325                 330                 335     


Ile Phe Ser Asp Asp Tyr Asp Ala Glu Glu Glu Pro Phe Lys Asn Thr 
            340                 345                 350         


Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe 
        355                 360                 365             


Asp Leu Asn Glu Ile Phe Glu Gln Leu Arg Phe Gln Ile Asp Leu Gly 
    370                 375                 380                 


Thr Tyr His Phe Ser Ile Tyr Asn Lys Leu Ile Gly Asp Glu Asp Glu 
385                 390                 395                 400 


Val Arg His Leu Thr His His Leu Tyr Gly Phe Ala Arg Ile Gln Asp 
                405                 410                 415     


Phe Ala Pro Arg Asn Gln Pro Glu Glu Trp Arg Lys Leu Val Lys Asp 
            420                 425                 430         


Leu Asp His Phe Glu Thr Ser Gln Lys Pro Tyr Ile Ser Lys Thr Ala 
        435                 440                 445             


Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Lys Phe Cys Ser 
    450                 455                 460                 


Thr His Asn Asn Leu Phe Pro Ser Leu Lys Arg Glu Lys Thr Cys Asn 
465                 470                 475                 480 


Gly Arg Ser Lys Phe Asn Leu Gly Thr Gln Phe Thr Ala Glu Ala Phe 
                485                 490                 495     


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu 
            500                 505                 510         


Thr Lys Asp Tyr Ser Arg Lys Glu Ser Ala Asp Lys Val Glu Gly Ile 
        515                 520                 525             


Ile Arg Lys Glu Ile Ser Asn Ile Tyr Ala Ile Tyr Asp Ala Phe Ala 
    530                 535                 540                 


Asn Asn Glu Ile Asn Ser Ile Ala Asp Leu Thr Cys Arg Leu Gln Lys 
545                 550                 555                 560 


Thr Asn Ile Leu Gln Gly His Leu Pro Lys Gln Met Ile Ser Ile Leu 
                565                 570                 575     


Glu Gly Arg Gln Lys Asp Met Glu Lys Glu Ala Glu Arg Lys Ile Gly 
            580                 585                 590         


Glu Met Ile Asp Asp Thr Gln Arg Arg Leu Asp Leu Leu Cys Lys Gln 
        595                 600                 605             


Thr Asn Gln Lys Ile Arg Ile Gly Lys Arg Asn Ala Gly Leu Leu Lys 
    610                 615                 620                 


Ser Gly Lys Ile Ala Asp Trp Leu Val Ser Asp Met Met Arg Phe Gln 
625                 630                 635                 640 


Pro Val Gln Lys Asp Thr Asn Asn Ala Pro Ile Asn Asn Ser Lys Ala 
                645                 650                 655     


Asn Ser Thr Glu Tyr Arg Met Leu Gln His Ala Leu Ala Leu Phe Gly 
            660                 665                 670         


Ser Glu Ser Ser Arg Leu Lys Ala Tyr Phe Arg Gln Met Asn Leu Val 
        675                 680                 685             


Gly Asn Ala Asn Pro His Pro Phe Leu Ala Glu Thr Gln Trp Glu His 
    690                 695                 700                 


Gln Thr Asn Ile Leu Ser Phe Tyr Arg Asn Tyr Leu Glu Ala Arg Lys 
705                 710                 715                 720 


Lys Tyr Leu Lys Gly Leu Lys Leu Gln Asn Trp Lys Gln Tyr Gln His 
                725                 730                 735     


Phe Leu Ile Leu Lys Val Gln Lys Thr Asn Arg Asn Thr Leu Val Thr 
            740                 745                 750         


Gly Trp Lys Asn Ser Phe Asn Leu Pro Arg Gly Ile Phe Thr Gln Pro 
        755                 760                 765             


Ile Arg Glu Trp Phe Glu Lys His Asn Asn Ser Lys Arg Ile Tyr Asp 
    770                 775                 780                 


Gln Ile Leu Ser Phe Asp Arg Val Gly Phe Val Ala Lys Ala Ile Pro 
785                 790                 795                 800 


Leu Tyr Phe Ala Glu Glu Tyr Lys Asp Asn Val Gln Pro Phe Tyr Asp 
                805                 810                 815     


Tyr Pro Phe Asn Ile Gly Asn Lys Leu Lys Pro Gln Lys Gly Gln Phe 
            820                 825                 830         


Leu Asp Lys Lys Glu Arg Val Glu Leu Trp Gln Lys Asn Lys Glu Leu 
        835                 840                 845             


Phe Lys Asn Tyr Pro Ser Glu Lys Lys Lys Thr Asp Leu Ala Tyr Leu 
    850                 855                 860                 


Asp Phe Leu Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys 
865                 870                 875                 880 


Asn Gln Asp Ile Val Thr Trp Leu Met Phe Lys Glu Leu Phe Lys Thr 
                885                 890                 895     


Thr Thr Val Glu Gly Leu Lys Ile Gly Glu Ile His Leu Arg Asp Ile 
            900                 905                 910         


Asp Thr Asn Thr Ala Asn Glu Glu Ser Asn Asn Ile Leu Asn Arg Ile 
        915                 920                 925             


Met Pro Met Lys Leu Pro Val Lys Thr Tyr Glu Thr Asp Asn Lys Gly 
    930                 935                 940                 


Asn Ile Leu Lys Glu Arg Pro Leu Ala Thr Phe Tyr Ile Glu Glu Thr 
945                 950                 955                 960 


Glu Thr Lys Val Leu Lys Gln Gly Asn Phe Lys Val Leu Ala Lys Asp 
                965                 970                 975     


Arg Arg Leu Asn Gly Leu Leu Ser Phe Ala Glu Thr Thr Asp Ile Asp 
            980                 985                 990         


Leu Glu Lys Asn Pro Ile Thr Lys  Leu Ser Val Asp His  Glu Leu Ile 
        995                 1000                 1005             


Lys Tyr  Gln Thr Thr Arg Ile  Ser Ile Phe Glu Met  Thr Leu Gly 
    1010                 1015                 1020             


Leu Glu  Lys Lys Leu Ile Asp  Lys Tyr Ser Thr Leu  Pro Thr Asp 
    1025                 1030                 1035             


Ser Phe  Arg Asn Met Leu Glu  Arg Trp Leu Gln Cys  Lys Ala Asn 
    1040                 1045                 1050             


Arg Pro  Glu Leu Lys Asn Cys  Val Asn Ser Leu Ile  Ala Val Arg 
    1055                 1060                 1065             


Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met Tyr Asp  Ala Thr Leu 
    1070                 1075                 1080             


Phe Ala  Lys Val Lys Lys Phe  Thr Leu Phe Pro Ser  Val Asp Thr 
    1085                 1090                 1095             


Lys Lys  Ile Glu Leu Asn Ile  Ala Pro Gln Leu Leu  Glu Ile Val 
    1100                 1105                 1110             


Gly Lys  Ala Ile Lys Glu Ile  Glu Lys Ser Glu Asn  Lys Asn 
    1115                 1120                 1125         


<210>  1877
<211>  1125
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1877

Met Glu Asp Asp Lys Lys Thr Thr Glu Ser Thr Tyr Thr Leu Asp Asn 
1               5                   10                  15      


Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val Tyr 
            20                  25                  30          


Ile Thr Val Asn His Ile Asn Lys Val Leu Glu Leu Lys Asn Lys Lys 
        35                  40                  45              


Asp Gln Asp Ile Leu Ile Asp Asn Asp Gln Asp Ile Leu Ala Ile Lys 
    50                  55                  60                  


Thr His Trp Glu Lys Val Asn Gly Asp Leu Asn Lys Thr Glu Arg Leu 
65                  70                  75                  80  


Arg Lys Leu Met Thr Lys His Phe Pro Phe Leu Glu Thr Ala Ile Tyr 
                85                  90                  95      


Thr Lys Asn Lys Glu Asp Lys Glu Glu Val Lys Gln Glu Lys Gln Ala 
            100                 105                 110         


Lys Ala Gln Ser Phe Asp Ser Leu Lys His Cys Leu Phe Leu Phe Leu 
        115                 120                 125             


Glu Lys Leu Gln Glu Ala Arg Asn Tyr Tyr Ser His Tyr Lys Tyr Ser 
    130                 135                 140                 


Glu Ser Thr Lys Glu Pro Met Leu Glu Lys Glu Leu Leu Lys Lys Met 
145                 150                 155                 160 


Tyr Asn Ile Phe Asp Asp Asn Ile Gln Leu Val Ile Lys Asp Tyr Gln 
                165                 170                 175     


His Asn Lys Asp Ile Asn Pro Asp Glu Asp Phe Lys His Leu Asp Arg 
            180                 185                 190         


Thr Lys Glu Glu Phe Asn Tyr Tyr Phe Thr Arg Asn Lys Lys Gly Asn 
        195                 200                 205             


Ile Thr Ala Ser Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys 
    210                 215                 220                 


Lys Asp Ala Ile Trp Met Gln Gln Lys Leu Thr Gly Phe Lys Asp Asn 
225                 230                 235                 240 


Arg Glu Ser Lys Lys Lys Met Thr His Glu Val Phe Cys Arg Ser Arg 
                245                 250                 255     


Met Leu Leu Pro Lys Leu Arg Leu Glu Ser Thr Gln Thr Gln Asp Trp 
            260                 265                 270         


Ile Leu Leu Asp Met Leu Asn Glu Leu Ile Arg Cys Pro Lys Ser Leu 
        275                 280                 285             


Tyr Glu Arg Leu Gln Gly Val Asp Arg Glu Lys Phe Lys Val Pro Phe 
    290                 295                 300                 


Asp Pro Ala Asp Glu Asp Tyr Asp Ala Glu Gln Glu Pro Phe Lys Asn 
305                 310                 315                 320 


Thr Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr 
                325                 330                 335     


Phe Asp Tyr Asn Glu Val Phe Ala Asn Leu Arg Phe Gln Ile Asp Leu 
            340                 345                 350         


Gly Thr Tyr His Phe Ser Ile Tyr Lys Lys Leu Ile Gly Gly Gln Lys 
        355                 360                 365             


Glu Asp Arg His Leu Thr His Lys Leu Tyr Gly Phe Glu Arg Ile Gln 
    370                 375                 380                 


Glu Phe Asp Lys Gln Asn Arg Pro Asp Glu Trp Lys Ala Ile Val Lys 
385                 390                 395                 400 


Asp Leu Asp Thr Tyr Glu Thr Ser Asn Glu Arg Tyr Ile Ser Glu Thr 
                405                 410                 415     


Thr Pro His Tyr His Leu Glu Asn Gln Lys Ile Gly Ile Arg Phe Arg 
            420                 425                 430         


Asn Gly Asn Lys Glu Ile Trp Pro Ser Leu Lys Thr Asn Gly Glu Asn 
        435                 440                 445             


Asn Glu Lys Ser Lys Tyr Lys Leu Asp Lys Gln Tyr Gln Ala Glu Ala 
    450                 455                 460                 


Phe Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu 
465                 470                 475                 480 


Leu Lys Lys Glu Glu Pro Asn Asn Asp Lys Lys Asn Ala Ser Ile Val 
                485                 490                 495     


Glu Gly Phe Ile Lys Arg Glu Ile Arg Asp Ile Tyr Lys Leu Tyr Asp 
            500                 505                 510         


Ala Phe Ala Asn Gly Glu Ile Asn Asn Ile Asp Asp Leu Glu Lys Tyr 
        515                 520                 525             


Cys Glu Asp Glu Gly Ile Pro Lys Arg His Leu Pro Lys Gln Met Val 
    530                 535                 540                 


Ala Ile Leu Tyr Asp Glu His Lys Asp Met Val Glu Glu Ala Lys Arg 
545                 550                 555                 560 


Lys Gln Lys Glu Met Val Lys Asp Thr Lys Lys Leu Leu Ala Ala Leu 
                565                 570                 575     


Glu Lys Gln Thr Gln Glu Glu Ile Glu Asp Gly Gly Arg Asn Ile Arg 
            580                 585                 590         


Leu Leu Lys Ser Gly Glu Ile Ala Arg Trp Leu Val Asn Asp Met Met 
        595                 600                 605             


Arg Phe Gln Pro Val Gln Lys Asp Asn Glu Gly Asn Pro Leu Asn Asn 
    610                 615                 620                 


Ser Lys Ala Asn Ser Thr Glu Tyr Gln Met Leu Gln Arg Ser Leu Ala 
625                 630                 635                 640 


Leu Tyr Asn Lys Glu Glu Lys Pro Thr Arg Tyr Phe Arg Gln Val Asn 
                645                 650                 655     


Leu Ile Asn Ser Ser Asn Pro His Pro Phe Leu Lys Trp Thr Lys Trp 
            660                 665                 670         


Glu Glu Cys Asn Asn Ile Leu Ser Phe Tyr Arg Ser Tyr Leu Thr Lys 
        675                 680                 685             


Lys Ile Glu Phe Leu Asn Lys Leu Lys Pro Glu Asp Trp Glu Lys Asn 
    690                 695                 700                 


Gln Tyr Phe Leu Lys Leu Lys Glu Pro Lys Thr Asn Arg Glu Thr Leu 
705                 710                 715                 720 


Val Gln Gly Trp Lys Asn Gly Phe Asn Leu Pro Arg Gly Ile Phe Thr 
                725                 730                 735     


Glu Pro Ile Arg Glu Trp Phe Lys Arg His Gln Asn Asp Ser Lys Glu 
            740                 745                 750         


Tyr Glu Lys Val Glu Ala Leu Lys Arg Val Gly Leu Val Thr Lys Val 
        755                 760                 765             


Ile Pro Leu Phe Phe Lys Glu Glu Tyr Phe Lys Glu Asp Ala Gln Lys 
    770                 775                 780                 


Glu Ile Asn Asn Cys Val Gln Pro Phe Tyr Gly Phe Pro Tyr Asn Val 
785                 790                 795                 800 


Gly Asn Ile His Lys Pro Asp Glu Lys Asp Phe Leu Pro Ser Glu Glu 
                805                 810                 815     


Arg Lys Lys Leu Trp Gly Asp Lys Lys Tyr Lys Phe Lys Gly Tyr Lys 
            820                 825                 830         


Ala Lys Val Lys Ser Lys Lys Leu Thr Asp Lys Glu Lys Glu Glu Tyr 
        835                 840                 845             


Arg Ser Tyr Leu Glu Phe Gln Ser Trp Asn Lys Phe Glu Arg Glu Leu 
    850                 855                 860                 


Arg Leu Val Arg Asn Gln Asp Ile Val Thr Trp Leu Leu Cys Thr Glu 
865                 870                 875                 880 


Leu Ile Asp Lys Met Lys Val Glu Gly Leu Asn Val Glu Glu Leu Gln 
                885                 890                 895     


Lys Leu Arg Leu Lys Asp Ile Asp Thr Asp Thr Ala Lys Gln Glu Lys 
            900                 905                 910         


Asn Asn Ile Leu Asn Arg Ile Met Pro Met Gln Leu Pro Val Thr Val 
        915                 920                 925             


Tyr Glu Ile Asp Asp Ser His Asn Ile Val Lys Asp Lys Pro Leu His 
    930                 935                 940                 


Thr Val Tyr Ile Glu Glu Thr Lys Thr Lys Leu Leu Lys Gln Gly Asn 
945                 950                 955                 960 


Phe Lys Ala Leu Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe 
                965                 970                 975     


Val Asp Thr Ser Ser Glu Ala Glu Leu Lys Asp Lys Pro Ile Ser Lys 
            980                 985                 990         


Ser Val Val Glu Tyr Glu Leu Gly  Glu Tyr Gln Asn Ala  Arg Ile Glu 
        995                 1000                 1005             


Ile Ile  Glu Asn Met Leu Ala  Leu Glu Gly Ala Leu  Ile Glu Lys 
    1010                 1015                 1020             


Asp Lys  Thr Leu Pro Thr Asn  Asn Phe Ser Ala Met  Leu Asn Gly 
    1025                 1030                 1035             


Trp Leu  Glu Gly Lys Asp Glu  Ala Asp Lys Ala Arg  Phe Gln Asn 
    1040                 1045                 1050             


Asp Val  Lys Leu Leu Val Ala  Val Arg Asn Ala Phe  Ser His Asn 
    1055                 1060                 1065             


Gln Tyr  Pro Met Arg Asn Arg  Ile Ala Phe Ala Asn  Ile Asn Pro 
    1070                 1075                 1080             


Phe Ser  Leu Ser Ser Ala Asp  Thr Ser Glu Glu Lys  Lys Leu Asp 
    1085                 1090                 1095             


Ile Ala  Asn Gln Leu Lys Asp  Lys Thr Lys Glu Thr  Ile Glu Lys 
    1100                 1105                 1110             


Ile Ile  Glu Ile Glu Lys Pro  Ile Glu Thr Lys Glu  
    1115                 1120                 1125 


<210>  1878
<211>  1214
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1878

Leu Ile Leu Ser Phe Ile Ile Phe Asn Phe Ile Val Ile Ile Asn Gln 
1               5                   10                  15      


His Thr Leu Asn Thr Tyr Thr Arg Lys Tyr Met Lys Asp Lys Ser Phe 
            20                  25                  30          


Ser Thr Ile Ser Ser Ala Ile Asn Glu Thr Ile Thr Thr Asp Asn Ile 
        35                  40                  45              


Lys Tyr Pro Glu Gln Leu Asn Leu Ile Leu Ser Lys Arg Leu Arg Pro 
    50                  55                  60                  


Lys Asn Glu Leu Gln Pro Leu Trp Ala Ala Tyr Phe Asn Met Ala Arg 
65                  70                  75                  80  


Tyr Asn Met Tyr Thr Thr Leu Val His Ile Ala Thr Ala Thr Gly Leu 
                85                  90                  95      


Ser Asp Glu Asp Asn Met Glu Asn Arg Met Asp Lys Met Arg Ile Leu 
            100                 105                 110         


Asn Glu Pro Val Glu Pro Glu Ile Glu His Arg Leu Arg Lys Leu Leu 
        115                 120                 125             


Cys Arg His Phe Pro Phe Ala Val Trp Met Ile Cys Asn Pro Ile Arg 
    130                 135                 140                 


Lys Lys Asp Ser Lys Glu Asp Ser Ala Asp Glu Asp Tyr Arg Val Ile 
145                 150                 155                 160 


Ser Val Lys Glu Leu Arg Asp Cys Leu Lys Thr Val Ser Tyr Thr Leu 
                165                 170                 175     


Asn Tyr Phe Arg Asn Tyr Tyr Ser His Thr Arg His Val Glu Thr Arg 
            180                 185                 190         


Ser Glu Asp Ile Ile Ala Ala Ser Arg Asn Ser Glu Lys Gln Thr Gly 
        195                 200                 205             


Ile Phe Leu Asn Lys Val Cys Thr Val Ala Thr Arg Arg Val Lys Ser 
    210                 215                 220                 


Arg Phe Ser Asp Lys Ser Asn Lys Gly Gln Ala Gly Met Ile Asp Asp 
225                 230                 235                 240 


Gln Ser Met Lys Phe Ile Thr Glu Gly Lys Val Lys Phe Arg Asn Asn 
                245                 250                 255     


Asn Gly Ile Lys Glu Thr Ile Tyr Asn Pro Asp His Phe Leu Tyr Pro 
            260                 265                 270         


Leu Phe Leu Asn Arg Ser Ser Ala Leu Arg Asp Gly Thr Asn Pro Glu 
        275                 280                 285             


Arg Leu Ser Thr Val Gly Lys Ile Gln Leu Ile Cys Leu Leu Leu Asp 
    290                 295                 300                 


Lys Lys Tyr Ile Thr Glu Phe Leu Asp Gln Ser Gly Phe Leu Ser Ala 
305                 310                 315                 320 


Phe Asn Asn Asn Ala Pro Ala Pro Lys Leu Ser Glu Arg Arg Leu Ile 
                325                 330                 335     


Leu Glu Val Leu Ser Asp Leu Arg Ile Arg Leu Pro Gln Arg Lys Ile 
            340                 345                 350         


Asp Ala Thr Cys Asn Asp Ile Gln Val Ala Leu Asp Met Leu Asn Glu 
        355                 360                 365             


Leu Lys Lys Cys Pro Lys Glu Leu Phe Glu Leu Leu Glu Ala Lys Asp 
    370                 375                 380                 


Lys Ala Thr Phe Ser Ile Leu Ser Ser Thr Gly Glu His Ile Leu Leu 
385                 390                 395                 400 


Arg Arg Ser Ser Asp Arg Phe Thr Gln Leu Ala Leu Gln Trp Phe Asp 
                405                 410                 415     


Val Asn Lys Ala Phe Ser Arg Ile Arg Phe His Met Asn Ala Gly Ile 
            420                 425                 430         


Phe Arg Tyr Leu Phe Asn Asp Ser Lys Thr Cys Ile Asp Gly Lys Thr 
        435                 440                 445             


Arg Leu Arg Val Leu Gln Glu Pro Leu Asn Cys Phe Gly Arg Ile Gln 
    450                 455                 460                 


Glu Val Glu Asp Ser Arg Glu Ser Asn Arg Asp Gly Asn Asp Gly Pro 
465                 470                 475                 480 


Trp Arg Gly Phe Glu Ile Lys Gly Phe Asp Glu Ala Ala Arg Asn Asp 
                485                 490                 495     


Val Asn Cys Leu Pro Tyr Ile Asn Asp Ser Arg Thr Arg Tyr Leu Ile 
            500                 505                 510         


Thr Glu Asp Asn Ile Gly Ile Arg Phe Ser Gly Asn Asp Glu Ala Cys 
        515                 520                 525             


Gly Asn Tyr Phe Pro Arg Ile Asp Glu Lys Asn Gly Lys Tyr Lys Val 
    530                 535                 540                 


Thr Cys Leu Pro Ala Gln Cys Met Ile Ser Ile Tyr Glu Leu Gln Ala 
545                 550                 555                 560 


Met Leu Phe Leu His Leu Leu Asn Pro Gly Asn Asp Gly Gly Ile Ala 
                565                 570                 575     


Pro Val Glu Lys Ile Ile Ile Asp Lys Val Glu Ser Tyr Arg Arg Phe 
            580                 585                 590         


Phe Ser Asp Ile Lys Asn Gly Leu Leu Thr Pro Ser Gly Leu Thr Glu 
        595                 600                 605             


Ser Ser Leu Asn Asp Lys Leu Thr Ser Thr Tyr Gly Ile Ser Leu Ser 
    610                 615                 620                 


Asp Ile Pro Asp Lys Met Lys Asp Tyr Leu Leu Lys Lys Asn Asn Lys 
625                 630                 635                 640 


Gly Arg Gly Phe Asn Ala Tyr Arg Asp Arg Leu Ile Glu Thr Leu Lys 
                645                 650                 655     


Glu Glu Thr Glu Tyr Arg Ile Lys Arg Leu Glu Glu Asn Leu Asn Ala 
            660                 665                 670         


Thr Asn Ser Asp Thr Asn Lys Pro Gly Lys Pro Gly Tyr Val Gln Ile 
        675                 680                 685             


Lys Pro Gly Ser Leu Ala Ser Phe Ile Ser Lys Asp Ile Val Phe Phe 
    690                 695                 700                 


Gln Glu Cys Asn Ala Asp Gln Lys Met Thr Gly Leu Asn Phe Ser Val 
705                 710                 715                 720 


Met Gln Gly Leu Ile Ala Thr Phe Gly Ser Gln Glu Gly Ala Thr Thr 
                725                 730                 735     


Asp Asp Leu Arg Met Ala Phe Arg Lys Ser Gly Leu Ile Ala Ala Asn 
            740                 745                 750         


Gly Ser Cys Gly Thr His Pro Phe Leu Ala Ile Ala Phe Asn Ala Gly 
        755                 760                 765             


Ala Lys Asn Thr Val Asp Leu Tyr Lys Glu Tyr Leu Asn Ala Arg Lys 
    770                 775                 780                 


Ser Tyr Leu Ser Gly Ile Ile Pro Asp Asn Ala Pro Phe Leu His Ala 
785                 790                 795                 800 


Asp Arg Ile Arg Trp Ala Val Asn Asp Asp Ala Tyr Tyr Lys Asp Tyr 
                805                 810                 815     


Ala Glu Arg Cys Leu Gln Arg Pro Val Ile Leu Pro Arg Arg Leu Phe 
            820                 825                 830         


Glu Ala Ser Ile Arg Glu Asn Leu Leu Ala Leu Asn Gly Glu Asn Ala 
        835                 840                 845             


Asn Ala Leu Lys Lys Val Ile Ile Gly Ala Gly Gly His Cys Asn Ser 
    850                 855                 860                 


Ala Phe Met Ile Asp Ser Tyr Phe Tyr Tyr Val Lys Asn Asp Ser Pro 
865                 870                 875                 880 


Gln Val Phe His Gly Ala Cys Glu Gly Asp Met Leu His Thr Tyr Gly 
                885                 890                 895     


His Arg Phe Phe Gln Val Val Arg Arg Asn Leu Lys Asn Ala Glu Ala 
            900                 905                 910         


Ile Leu Ser Lys Leu Lys Lys Asp Ser Asn Thr His Asn Thr Tyr Ile 
        915                 920                 925             


Gly Ala Leu Ser Asp Ala Ile Cys Trp Ala Lys Glu Asn Pro Ile Lys 
    930                 935                 940                 


Pro Thr Phe Ser Val Gly Arg Ser Arg Leu Asn Asn His Ser Glu Asn 
945                 950                 955                 960 


Glu Ile Ala Ala Met Ile Lys Arg Ala Phe Asn Glu Tyr Met Ala Thr 
                965                 970                 975     


Glu Lys Thr Leu Arg Arg Tyr Val Ile Gln Asp Glu Leu Leu Phe Leu 
            980                 985                 990         


Ala Ala Met Lys Thr Ile Lys Ser  Lys Leu Gly Val Pro  Asp Ser Glu 
        995                 1000                 1005             


Trp Lys  Leu Gly Ser Ile Gly  Ser Lys Ser Gly Ser  Ile Leu Asp 
    1010                 1015                 1020             


Lys Glu  Leu Pro Leu Ile Gln  Thr Pro Ala Lys Phe  Ser Asn Ile 
    1025                 1030                 1035             


Lys Arg  Arg Pro Asn Lys Thr  Ile Thr Lys Asp Leu  Val Glu Leu 
    1040                 1045                 1050             


Val Ile  Glu Gln His Asn Val  Ser Ile Lys Asp Tyr  Gly Glu Ile 
    1055                 1060                 1065             


Tyr Arg  Ile Leu Ala Asp Glu  Arg Leu Tyr Gly Leu  Leu Lys Tyr 
    1070                 1075                 1080             


His Lys  Asn Glu Thr Val Leu  Ala Ser Asp Leu Lys  Asn Glu Ile 
    1085                 1090                 1095             


Glu Lys  Tyr Asp Glu Lys Arg  Val Lys Val Phe Glu  Asp Ile Met 
    1100                 1105                 1110             


Asn Tyr  Glu Lys Lys Ile Thr  Asn Gly Val Thr Asp  Arg Gln Leu 
    1115                 1120                 1125             


Cys Glu  Ser Met Asp His Ala  Lys Asp Ile Asp Phe  Lys Val Met 
    1130                 1135                 1140             


Gln Thr  Phe Asp Thr Met Asn  Asp Asn Leu Thr Lys  Met Glu Leu 
    1145                 1150                 1155             


Arg Ser  Ile Arg Asn Ala Phe  Cys His Asn Ser Tyr  Pro Asp Val 
    1160                 1165                 1170             


Asn Ala  Phe Asp Asn Ser Ser  Gly Thr Thr Lys Arg  Ile Arg Ile 
    1175                 1180                 1185             


His Asn  Ala Asp Ile Pro Gly  Thr Ala Glu Lys Ile  Ser Glu Ile 
    1190                 1195                 1200             


Val Asn  Asp Ile Ser Ser Lys  Thr Glu Ala Lys 
    1205                 1210                 


<210>  1879
<211>  1216
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1879

Val Ser Ile Val Ser Cys Leu Ser Ile Ile Ser Lys Lys Thr Ser Leu 
1               5                   10                  15      


Phe Leu Gly Arg Ile Val Phe Ser Leu Tyr Leu Cys Lys Ile Trp Asn 
            20                  25                  30          


Ile Asp Val Ser Gly Lys Pro Tyr Asn Leu Leu Ile Ile Lys Ile Pro 
        35                  40                  45              


Arg Leu Thr Ile Asn Thr Leu Asn Met Asn Val Ile Glu Ser Phe Leu 
    50                  55                  60                  


Pro Leu Asn Thr Lys Glu Lys Ile Asp Gln Leu Met Ala Ile Ile Lys 
65                  70                  75                  80  


Ser Glu Pro Lys Ala Met Asn Gln Asn Ala Trp His Met Ile Phe Gly 
                85                  90                  95      


Asn Ile Gly Lys Ser Lys Met Gln Met Tyr Phe Ile Glu Lys Tyr Pro 
            100                 105                 110         


Gln Ser Leu Phe Ala Ala Pro Gly Asn Tyr Ile Pro Ser Cys Asn Gly 
        115                 120                 125             


Gln Gly Gln Glu Glu Lys Asn Pro Gln Gln Pro Gln Val Gln Gln His 
    130                 135                 140                 


Glu Arg Gln Thr Asp Ile Pro Val Pro Pro Thr Ser Leu Lys Asp Asn 
145                 150                 155                 160 


Arg Phe Leu Tyr Ala Thr Tyr Ile Glu Met Ala Phe His Asn Met Phe 
                165                 170                 175     


Leu Asn Ile Lys His Ile Tyr Gly Val Val Phe Gly Arg Asp Ile Met 
            180                 185                 190         


Ala Glu Ala Lys Ala Asn Tyr Glu Ala Leu Asn Pro Glu Lys Lys Trp 
        195                 200                 205             


Asp Glu Asp Phe Ala Asn Glu Phe Leu Val Trp Lys Pro Met Phe Glu 
    210                 215                 220                 


Ala Phe Asn Asn Gly Asn Val Glu Glu Lys Gln Lys Val Gly Glu Met 
225                 230                 235                 240 


Leu Ser Arg His Phe Pro Leu Leu Val Pro Phe Thr Asp Phe Thr Asn 
                245                 250                 255     


His Glu Ser Asn Tyr Lys Asn Leu Thr Ile Val Gly Ile Leu Arg Arg 
            260                 265                 270         


Leu Ser Gln Val Leu Arg Val Leu Arg Asn Leu Tyr Ser His Tyr Arg 
        275                 280                 285             


Ile Glu Leu Phe Glu Asn Gln Lys Lys Val Tyr Leu Asp Asn Glu Tyr 
    290                 295                 300                 


Leu Ile Ile Arg Cys Thr Met Asn Ala Tyr Met Gly Ala Arg Arg Val 
305                 310                 315                 320 


Ile Lys Asp Arg Phe Ser Tyr Asp Glu Lys Asp Met Arg Cys Thr Asp 
                325                 330                 335     


Gln Tyr Gln Phe Val Asp Glu Arg Gly Arg Arg Leu Lys Glu Lys Val 
            340                 345                 350         


Glu Ile Lys Gly Phe Arg Tyr Lys Ile Gly Glu Lys Gly Lys Asp Ser 
        355                 360                 365             


Lys Leu His Phe Thr Pro Phe Gly Leu Val Ala Phe Ile Ser Leu Phe 
    370                 375                 380                 


Leu Glu Lys Lys Tyr Ser Lys Ile Leu Thr Asp Lys Leu Arg Leu Ile 
385                 390                 395                 400 


Pro Ile Gln Asp Gln His Ile Ile Asn Glu Met Leu Ala Val Tyr Arg 
                405                 410                 415     


Ile Arg Leu Asn Ala Gln Lys Leu Asn Ile Ser Lys Asp Ala Asp Leu 
            420                 425                 430         


Leu Ala Leu Asp Ile Ile Asn Glu Leu Gln Arg Cys Pro Lys Asp Leu 
        435                 440                 445             


Phe Ser Leu Leu Ser Pro Ser Asp Gln Lys Lys Phe Arg His Glu Ser 
    450                 455                 460                 


Glu Ala Asn Asp Glu Val Leu Met Val Arg His Ser Asp Arg Phe Pro 
465                 470                 475                 480 


Phe Leu Val Met Lys Tyr Ile Asp Asp Cys Gln Leu Phe Asp Asn Ile 
                485                 490                 495     


Arg Phe Gln Val Ser Leu Gly Lys Tyr Phe Tyr Lys Phe Tyr Asp Lys 
            500                 505                 510         


Asn Cys Ile Asp Ser Glu Thr Arg Val Arg Ala Leu Ser Lys Asn Leu 
        515                 520                 525             


Asn Gly Phe Gly Arg Leu Ser Lys Ile Glu Ala Met Arg Glu Gly Cys 
    530                 535                 540                 


Trp Glu Asp Ser Ile Arg Gln Tyr Asp Asp Ile His Lys Asn Thr Val 
545                 550                 555                 560 


Asp Glu Lys Pro Tyr Val Thr Asp His His Ala Lys Tyr Val Ile Asn 
                565                 570                 575     


Gly Asn Arg Ile Ala Met Arg Ile Ile Arg Glu Glu Glu Lys Ala Tyr 
            580                 585                 590         


Leu Pro Glu Leu Asn Ala Glu Gly Val Arg Asn Leu Ala Pro Thr Cys 
        595                 600                 605             


Trp Leu Ser Ile Tyr Asp Leu Ser Ser Leu Ala Phe Leu Leu Tyr Leu 
    610                 615                 620                 


Thr Asn Gly Asp Phe Val Glu Gly Ile Ile Glu Asn Thr Val Glu Asn 
625                 630                 635                 640 


Tyr His Lys Leu Phe Lys Asp Ile Glu Asn Gly Thr Met Leu Pro Val 
                645                 650                 655     


Ala Asn Glu Glu Glu Leu Asp Ser Leu Leu Cys Arg Asn Tyr Gly Gly 
            660                 665                 670         


Ile Lys Gln Lys Asp Ile Pro Lys Asn Met Leu Asp Tyr Leu Leu Arg 
        675                 680                 685             


Lys Thr Ser Asp Ala Arg Lys Arg Phe Val Glu Phe Ser Lys Ser Ile 
    690                 695                 700                 


Ile Asp Arg Met Ile Ser Gln Thr Glu Tyr Lys Ile Glu Gln Ile Lys 
705                 710                 715                 720 


Arg Gln Glu Glu Gln Cys Arg Gln Asn Lys Ile Gly Lys Lys Ser Tyr 
                725                 730                 735     


Val Ile Ile Lys Asp Gly Lys Leu Ala Ser Phe Leu Ala Asn Asp Ile 
            740                 745                 750         


Met Leu Phe Gln Pro Asn Asp Ser Glu Asn Ser Asn Lys Leu Thr Gly 
        755                 760                 765             


Leu Asn Phe Arg Ile Leu Gln Ser Thr Leu Ala Thr Met Lys Glu Cys 
    770                 775                 780                 


Gly Ile Asp Gln Leu Lys Arg Thr Leu Thr Ser Ala His Ile Ile Gly 
785                 790                 795                 800 


Glu Ala Asn Asp Glu Tyr Cys Asn Pro Ile Val Met Lys Met Met Arg 
                805                 810                 815     


Lys Arg Val Pro Glu Asn Thr Arg Asp Phe Tyr Lys Ser Tyr Leu Lys 
            820                 825                 830         


Ala Arg Leu Glu Tyr Leu Asn Glu Cys Lys Arg Lys Ala Asp Tyr Glu 
        835                 840                 845             


Asn Leu Ser Phe Leu His Ser Asn Arg Ser Lys Trp Gln Glu His Asp 
    850                 855                 860                 


Asp Glu Phe Cys Arg Leu Leu Ala Gly Arg Tyr Leu His Asp Glu Asn 
865                 870                 875                 880 


Gly Gly Thr Glu Phe Glu Lys Ser Ile Asn Leu Pro Ser Gly Met Phe 
                885                 890                 895     


Asp Lys Tyr Ile Arg Glu Lys Leu Cys Glu Val Pro Ala Leu Lys Asp 
            900                 905                 910         


Ile Ala Asn Asp Glu Thr Lys Asn Val Ser Tyr Leu Ile Tyr Ala Tyr 
        915                 920                 925             


Phe Lys Asn Val Cys Asn Asp Asp Cys Leu Phe Phe Tyr Glu Ala Gly 
    930                 935                 940                 


Arg Ser Tyr Arg Leu Phe Lys Leu Leu Gly Met Asn Gly Ser Lys Thr 
945                 950                 955                 960 


Ala Gln Asp Ile Arg Leu Met Leu Asn Arg Lys His Lys Thr Ser Leu 
                965                 970                 975     


Tyr Lys Glu Ile Asp Lys Tyr Leu Ile Ser Ile Pro Leu Ala Glu Arg 
            980                 985                 990         


Glu Gln Glu Lys Ala Arg Leu Met  Gly Leu Leu Lys Gly  Met Lys Asn 
        995                 1000                 1005             


Ser Glu  Thr Asp Phe Lys Arg  Phe Lys Ile Gln Asp  Ile Leu Leu 
    1010                 1015                 1020             


Phe Leu  Ile Ala Lys Lys Leu  Phe Lys Asp Asn Val  Gln Asp Asp 
    1025                 1030                 1035             


Val Gln  His Thr Ala Phe Glu  Ser Leu Lys Leu Lys  Ser Leu Lys 
    1040                 1045                 1050             


Asp Thr  Asp Gly Leu Ser Gln  Lys Ile Arg Ile Ser  Val Lys Ile 
    1055                 1060                 1065             


Lys Ser  Lys Asn Gly Tyr Glu  Lys Glu Ile Lys Lys  Pro Glu Leu 
    1070                 1075                 1080             


Lys Leu  Lys Asn Tyr Ala Asp  Phe Tyr Lys Leu Leu  Asn Asp Arg 
    1085                 1090                 1095             


Arg Leu  Pro Ala Leu Leu Asp  Leu Val Arg Glu His  Ser Ile Asp 
    1100                 1105                 1110             


Tyr Asp  Ser Leu Val Asp Glu  Phe Gly Gly Tyr Asp  Lys Val Arg 
    1115                 1120                 1125             


Pro Asn  Val Met Lys Asp Val  Leu Lys Tyr Glu Arg  Lys Tyr Tyr 
    1130                 1135                 1140             


Asp Asn  His Ala Asp Ser Asp  Glu Ser Leu Asp Phe  Gly Ser Met 
    1145                 1150                 1155             


Leu Asp  Asn Ser Ser Phe Asn  Glu Glu Glu Lys Asp  Leu Leu Arg 
    1160                 1165                 1170             


Lys Ile  Arg Asn Ser Phe Ala  His Asn Thr Tyr Pro  Lys Tyr Tyr 
    1175                 1180                 1185             


Ile Val  Asn Lys Ala Gly Asp  Pro His Leu Pro Glu  Lys Ala Ile 
    1190                 1195                 1200             


Lys Cys  Ser Glu Lys Phe Ser  Ser Asp Ile Asn Asn  Glu 
    1205                 1210                 1215     


<210>  1880
<211>  989
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1880

Met Ala Asn Thr Thr Leu Pro Asn Tyr Gln Lys Asn Thr Ala Asp Thr 
1               5                   10                  15      


Thr Ala Glu Leu Cys Leu Phe Tyr Asn Leu Ala Phe Asp Arg Ile Gln 
            20                  25                  30          


Asp Leu Leu Phe Ser Tyr Glu Gln Lys Lys Ile Glu Ile Glu Ser Phe 
        35                  40                  45              


Asn Thr Phe Thr Gly Glu Gln Leu Cys Gln Gln His Phe Ser Lys Gln 
    50                  55                  60                  


Thr Tyr Leu Cys Leu Lys Val Tyr Leu Trp Lys Glu Pro Val Ser Arg 
65                  70                  75                  80  


Arg Tyr Thr Gln Ile Lys Gln His Asp Ile Cys Met Val Asn Thr Ile 
                85                  90                  95      


Leu Gln Lys Leu Val His Leu Arg Asn Phe His Ser His Tyr Tyr His 
            100                 105                 110         


Asp Ala Ser Val Leu Gln Phe Pro His Asp Leu Val Ser Phe Ile Ala 
        115                 120                 125             


Leu Gln Leu Gln Thr Val Lys Gln Lys Leu Ala Ala Lys Gln Pro Glu 
    130                 135                 140                 


Cys Ala Gly Tyr Tyr Gly Glu Leu Glu Lys Asp Ile Lys Glu Tyr Gly 
145                 150                 155                 160 


Pro Pro Asp Gly Glu Lys Lys Gln Asp Val Tyr Lys His Phe Tyr Phe 
                165                 170                 175     


Phe Asp Gly Asn Gly Tyr Ile Gln Pro Glu Gly Lys Asn Phe Phe Leu 
            180                 185                 190         


Ser Phe Phe Leu Val Lys Gly Glu Met Gln Arg Phe Leu Lys Lys Arg 
        195                 200                 205             


Lys Arg Cys Lys Arg Asp Asn Gly Glu Arg Tyr Gln Val Lys Asn Lys 
    210                 215                 220                 


Leu Tyr Thr Glu Leu Cys His Arg Asp Ala Ser Asn Arg Phe Phe Thr 
225                 230                 235                 240 


Arg Gly Lys Glu Asp Tyr Cys Glu Gly Asn Glu Pro Leu Arg Arg Gln 
                245                 250                 255     


Phe Asn Thr Ile Leu Asn Tyr Leu Leu Ser Lys Pro Val Ala Asp Lys 
            260                 265                 270         


Ser Tyr Met Pro Pro Pro Leu Pro Gly Glu Leu Phe Ser Lys Asp Glu 
        275                 280                 285             


Met Leu Gln Met Lys Glu Gln Arg Ser Asp Glu Pro Gly Gly Glu Thr 
    290                 295                 300                 


Val Tyr Ile Arg Arg Ser Ser Lys Phe Val Asp Ile Ala Val Arg Phe 
305                 310                 315                 320 


Phe Met Asp Met Pro Leu Leu Gly Tyr Lys Asn Val Glu Pro Ile Asp 
                325                 330                 335     


Trp Glu Val Arg Asn Phe Thr His Thr Lys Ile Glu Lys Gln Leu Ser 
            340                 345                 350         


Ala Arg Ile Ser Thr Asp Asp Asn Lys Thr Tyr Met Glu Ala Lys Asp 
        355                 360                 365             


Gly Trp His Arg Thr Tyr Arg Ala Gly Asn Phe Pro Arg Val Val Asn 
    370                 375                 380                 


Asn His Ile Arg Phe Val Leu Asp Gly Cys Ser Thr Pro Phe Ile Ile 
385                 390                 395                 400 


Asn Val Arg Glu Leu Lys Asn Trp Leu Tyr Phe Leu Leu Ala Gly Asn 
                405                 410                 415     


Ala Asp Ala Tyr Ser Lys Cys Ile Ala Leu Ile Lys Glu Tyr Gly Gln 
            420                 425                 430         


Gln Tyr Ala His Ala Thr Gly Glu Leu Cys Lys Thr His Ser Leu Asp 
        435                 440                 445             


Cys Ser Arg Tyr Pro Leu Val Phe His Asp Gly Thr Val Glu Ser Ala 
    450                 455                 460                 


Lys Leu Ser Asp Ala His Ile Lys Leu Leu Thr Gln Glu Pro Phe Cys 
465                 470                 475                 480 


Thr Asp Thr Tyr Arg Gln Lys Ile Leu Ala Arg Ile His Thr Thr Leu 
                485                 490                 495     


Asp Phe Leu Lys Glu Thr Lys Arg Lys Lys Thr Glu Leu Ser Arg Asn 
            500                 505                 510         


Arg Lys Asn Arg Val Ile Met Lys Cys Leu Asn Trp Tyr Leu Pro Gln 
        515                 520                 525             


Gln Ala Lys Leu Lys Pro Asp Glu Val Asn Leu Leu Ser Ile Tyr Asn 
    530                 535                 540                 


Phe Thr Ala Asp Asn Glu Gly Leu Lys Asn Glu Ser Arg Asp Ser Ile 
545                 550                 555                 560 


Ile Gln Pro Leu Met His Lys Leu His Lys Ala Thr Glu Gly Ala Phe 
                565                 570                 575     


Asn Cys Ile Gln Ala Ser Asn Ser Leu Asp Asp Leu Phe Asp Thr Met 
            580                 585                 590         


Leu Asp Lys Lys Arg Gln Ser Leu Gln Gln Leu Leu Pro Lys Ile Ala 
        595                 600                 605             


Gln Leu Pro Leu Pro Glu Leu His Leu Leu Ala Ala Lys Leu His Val 
    610                 615                 620                 


Arg Met Pro Gly Ala Asp Thr Ala Arg Asn Gly Asn Asp Arg Leu Gln 
625                 630                 635                 640 


Glu Leu Gln Ser Thr Leu Ser Ser Asn Pro Val Leu Leu Pro Asn Gly 
                645                 650                 655     


Phe Phe Lys Arg Asn Leu Ala Pro Asp Glu Asn Tyr Gln Val Ser Thr 
            660                 665                 670         


Leu Val Arg Lys Arg Ala Val Trp Thr Asn Ile Leu Pro Arg Asp Asn 
        675                 680                 685             


Tyr His Leu Gly Glu Gln Asp Ser Phe Val Asn Gly Glu His Ser Pro 
    690                 695                 700                 


Ala Pro Ile Arg Arg Ala Val Leu Asp Ala Val Glu Thr His Phe Asp 
705                 710                 715                 720 


Glu Leu His Arg Ala Tyr Val Leu Ser Ala Thr Glu Leu Lys Gln Gln 
                725                 730                 735     


Ala Ser Ala Gln Gly Lys Gln Ala Pro Lys Thr Phe Lys Leu Phe Val 
            740                 745                 750         


Glu Ser Phe Ala Gln Lys Leu Pro Gly Thr Asp Ala Lys Glu Leu Arg 
        755                 760                 765             


Pro Ala Val Asp Leu Tyr Lys Lys Leu Lys Glu Thr Glu Val Gln Asp 
    770                 775                 780                 


Ala Leu Leu Ala Gln Ile Leu Phe Lys Tyr His Asn Leu Asp Leu Pro 
785                 790                 795                 800 


Leu Arg Glu Arg Glu Leu Lys Thr Cys Lys Ile Ala Glu Leu His Arg 
                805                 810                 815     


His Glu Tyr Thr Ile Gln Leu Asp Tyr Asn Val Ser Ile Pro Tyr Lys 
            820                 825                 830         


Gln Leu Asp Asp Leu Ala Thr His Trp Asp Arg Lys Lys Leu Val Ala 
        835                 840                 845             


Leu Phe Lys Asn Asn Lys Tyr Trp Asn Trp His Leu Arg Ala Glu Leu 
    850                 855                 860                 


Gln Asn Lys Gly Ile Asp Thr Asp Met Arg Met Ile Asn Tyr Val Leu 
865                 870                 875                 880 


Asn Ser Leu Tyr Glu Asp Ser Phe Arg Tyr Ile Gln Leu Val Leu Ala 
                885                 890                 895     


Val Glu Lys Lys Ile Leu Glu Gly Thr Gly Arg Asp Ala Leu Asn Gln 
            900                 905                 910         


Leu Ile Ala Gly Thr Ala Gly Ser Gly Arg Ala Arg Ile Glu Phe Gly 
        915                 920                 925             


Ser Leu Leu Asp Thr Thr Ala Met Lys Gly Lys Ala Lys Lys Lys Phe 
    930                 935                 940                 


Val Arg Leu Arg Asn Ser Ala Phe His Thr Phe Val Pro Asp Asn Asn 
945                 950                 955                 960 


Leu Gln Tyr Cys Glu Glu Lys Glu Arg Leu Ala Thr His Phe Gly Ile 
                965                 970                 975     


Arg Leu Glu Gln Lys Lys Gly Lys Gly Phe Tyr Arg Lys 
            980                 985                 


<210>  1881
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1881

Val Lys Met Glu Asp Asp Lys Lys Thr Thr Glu Ser Thr Asn Met Leu 
1               5                   10                  15      


Asp Asn Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Val Tyr Ile Thr Val Asn His Ile Asn Lys Val Leu Glu Leu Lys Asn 
        35                  40                  45              


Lys Lys Asp Gln Asp Ile Ile Ile Asp Asn Asp Gln Asp Ile Leu Ala 
    50                  55                  60                  


Ile Lys Thr Leu Trp Glu Lys Val Asn Gly Asp Leu Asn Lys Thr Glu 
65                  70                  75                  80  


Arg Leu Arg Glu Leu Met Thr Lys His Phe Pro Phe Leu Glu Thr Ala 
                85                  90                  95      


Ile Tyr Ser Lys Asn Lys Glu Asp Lys Glu Glu Val Lys Gln Glu Lys 
            100                 105                 110         


Gln Ala Lys Ala Gln Ser Phe Asp Ser Leu Lys His Cys Leu Phe Leu 
        115                 120                 125             


Phe Leu Glu Lys Leu Gln Glu Ala Arg Asn Tyr Tyr Ser His Tyr Lys 
    130                 135                 140                 


Tyr Ser Glu Ser Thr Lys Glu Pro Met Leu Glu Lys Glu Leu Leu Lys 
145                 150                 155                 160 


Lys Met Tyr Asn Ile Phe Asp Asp Asn Ile Gln Leu Val Ile Lys Asp 
                165                 170                 175     


Tyr Gln His Asn Lys Asp Ile Asn Pro Asn Glu Asp Phe Lys His Leu 
            180                 185                 190         


Asp Arg Thr Glu Glu Asp Phe Asn Tyr Tyr Phe Thr Arg Asn Lys Lys 
        195                 200                 205             


Gly Asn Ile Thr Ala Ser Gly Leu Leu Phe Phe Val Ser Leu Phe Leu 
    210                 215                 220                 


Glu Lys Lys Asp Ala Ile Trp Met Gln Gln Lys Leu Arg Gly Phe Lys 
225                 230                 235                 240 


Asp Asn Arg Glu Ser Lys Lys Lys Met Thr His Glu Val Phe Cys Arg 
                245                 250                 255     


Arg Arg Met Leu Leu Pro Lys Leu Arg Leu Glu Ser Thr Gln Thr Gln 
            260                 265                 270         


Asp Trp Ile Leu Leu Asp Met Leu Asn Glu Leu Ile Arg Cys Pro Lys 
        275                 280                 285             


Ser Leu Tyr Glu Arg Leu Gln Gly Glu Tyr Arg Lys Lys Phe Asn Val 
    290                 295                 300                 


Pro Phe Asp Pro Ala Asp Glu Asp Tyr Asp Ala Glu Gln Glu Pro Phe 
305                 310                 315                 320 


Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Val Leu 
                325                 330                 335     


Arg Tyr Phe Asp Tyr Asn Glu Ile Phe Thr Asn Leu Arg Phe Gln Ile 
            340                 345                 350         


Asp Leu Gly Thr Tyr His Phe Ser Ile Tyr Lys Lys Leu Ile Gly Gly 
        355                 360                 365             


Gln Lys Glu Asp Arg His Leu Thr His Lys Leu Tyr Gly Phe Glu Arg 
    370                 375                 380                 


Ile Gln Glu Phe Ala Lys Gln Asn Arg Thr Asp Glu Trp Lys Ala Ile 
385                 390                 395                 400 


Val Lys Asp Leu Asp Thr Tyr Glu Thr Ser Asn Glu Arg Tyr Ile Ser 
                405                 410                 415     


Glu Thr Thr Pro His Tyr His Leu Glu Asn Gln Lys Ile Gly Ile Arg 
            420                 425                 430         


Phe Arg Asn Gly Asn Asn Asp Ile Trp Pro Ser Leu Glu Thr Asn Gly 
        435                 440                 445             


Glu Asn Asn Glu Lys Ser Lys Tyr Lys Leu Asp Lys Pro Tyr Gln Ala 
    450                 455                 460                 


Glu Ala Phe Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr 
465                 470                 475                 480 


Leu Leu Leu Lys Lys Glu Glu Pro Asn Asn Asp Lys Lys Asn Ala Ser 
                485                 490                 495     


Ile Val Glu Gly Phe Ile Lys Arg Glu Ile Arg Asp Ile Tyr Lys Leu 
            500                 505                 510         


Tyr Asp Ala Phe Ala Asn Gly Glu Ile Asn Ser Glu Glu Glu Leu Lys 
        515                 520                 525             


Glu Tyr Leu Lys Gly Lys Asp Ile Glu Ile Val His Leu Pro Lys Gln 
    530                 535                 540                 


Met Ile Ala Ile Leu Glu Ser Lys Pro Lys Asp Met Val Lys Glu Ala 
545                 550                 555                 560 


Lys Arg Lys Gln Lys Glu Met Val Lys Asp Thr Lys Lys Leu Leu Ala 
                565                 570                 575     


Ala Leu Glu Lys Gln Thr Gln Glu Glu Ile Glu Asp Gly Gly Arg Asn 
            580                 585                 590         


Ile Arg Leu Leu Lys Ser Gly Glu Ile Ala Arg Trp Leu Val Asn Asp 
        595                 600                 605             


Met Met Arg Phe Gln Pro Val Gln Lys Asp Asn Glu Gly Asn Pro Leu 
    610                 615                 620                 


Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln Met Leu Gln Arg Ser 
625                 630                 635                 640 


Leu Ala Leu Tyr Asn Lys Glu Glu Lys Pro Thr Arg Tyr Phe Arg Gln 
                645                 650                 655     


Val Asn Leu Ile Asn Ser Ser Asn Pro His Pro Phe Leu Lys Trp Thr 
            660                 665                 670         


Lys Trp Glu Glu Cys Asn Asn Ile Leu Ser Phe Tyr Arg Ser Tyr Leu 
        675                 680                 685             


Thr Lys Lys Ile Glu Phe Leu Asn Lys Leu Lys Pro Glu Asp Trp Glu 
    690                 695                 700                 


Lys Asn Gln Tyr Phe Leu Lys Leu Lys Glu Pro Lys Thr Asn Arg Lys 
705                 710                 715                 720 


Thr Leu Val Gln Gly Trp Lys Asn Gly Phe Asn Leu Pro Arg Gly Ile 
                725                 730                 735     


Phe Thr Glu Pro Ile Arg Glu Trp Phe Lys Arg His Gln Asn Asp Ser 
            740                 745                 750         


Glu Glu Tyr Lys Lys Val Glu Ala Leu Lys Arg Val Gly Leu Val Ala 
        755                 760                 765             


Lys Val Ile Pro Leu Phe Phe Lys Glu Glu Tyr Phe Lys Glu Asp Ala 
    770                 775                 780                 


Gln Lys Glu Ile Asn Asn Cys Val Gln Pro Phe Tyr Ser Phe Pro Tyr 
785                 790                 795                 800 


Asn Val Gly Asn Ile His Lys Pro Asp Glu Lys Asp Phe Leu Pro Ser 
                805                 810                 815     


Glu Glu Arg Lys Lys Leu Trp Gly Asp Lys Lys Tyr Lys Phe Lys Gly 
            820                 825                 830         


Tyr Lys Ala Lys Glu Lys Ser Lys Lys Leu Thr Asp Lys Glu Lys Glu 
        835                 840                 845             


Glu Tyr Arg Ser Tyr Leu Glu Phe Gln Ser Trp Asn Lys Phe Glu Arg 
    850                 855                 860                 


Glu Leu Arg Leu Val Arg Asn Gln Asp Ile Val Thr Trp Leu Leu Cys 
865                 870                 875                 880 


Thr Glu Leu Ile Asp Lys Leu Lys Val Glu Gly Leu Asn Val Glu Glu 
                885                 890                 895     


Leu Gln Lys Leu Arg Leu Lys Asp Ile Asp Thr Asp Thr Ala Lys Lys 
            900                 905                 910         


Glu Lys Asn Asn Ile Leu Asn Arg Ile Met Pro Met Gln Leu Pro Val 
        915                 920                 925             


Thr Val Tyr Glu Ile Asp Asp Ser His Asn Ile Val Lys Asp Arg Pro 
    930                 935                 940                 


Leu His Thr Val Tyr Ile Glu Glu Thr Lys Thr Lys Leu Leu Lys Gln 
945                 950                 955                 960 


Gly Asn Phe Lys Ala Leu Val Lys Asp Arg Arg Leu Asn Gly Leu Phe 
                965                 970                 975     


Ser Phe Val Asp Thr Ser Ser Glu Ala Asp Leu Lys Asp Lys Pro Ile 
            980                 985                 990         


Ser Lys Ser Val Val Glu Tyr Glu  Leu Gly Glu Tyr Gln  Asn Ala Arg 
        995                 1000                 1005             


Ile Glu  Thr Ile Lys Asp Met  Leu Leu Leu Glu Lys  Thr Leu Ile 
    1010                 1015                 1020             


Lys Lys  Tyr Lys Lys Leu Pro  Thr Asp Asn Phe Ser  Asp Met Leu 
    1025                 1030                 1035             


Asn Gly  Trp Leu Glu Gly Lys  Asp Glu Ser Asp Lys  Ala Arg Phe 
    1040                 1045                 1050             


Gln Asn  Asp Val Lys Leu Leu  Val Ala Val Arg Asn  Ala Phe Ser 
    1055                 1060                 1065             


His Asn  Gln Tyr Pro Met Arg  Asn Arg Ile Ala Phe  Ala Asn Ile 
    1070                 1075                 1080             


Asn Pro  Phe Ser Leu Ser Ser  Ala Asn Thr Ser Glu  Glu Lys Lys 
    1085                 1090                 1095             


Leu Asp  Ile Ala Asn Gln Leu  Lys Asp Lys Thr His  Lys Thr Ile 
    1100                 1105                 1110             


Glu Lys  Ile Ile Glu Ile Glu  Lys Pro Ile Glu Thr  Lys Glu 
    1115                 1120                 1125         


<210>  1882
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1882

Val Lys Met Glu Asp Asp Lys Lys Thr Thr Glu Ser Thr Asn Met Leu 
1               5                   10                  15      


Asp Asn Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Val Tyr Ile Thr Val Asn His Ile Asn Lys Val Leu Glu Leu Lys Asn 
        35                  40                  45              


Lys Lys Asp Gln Asp Ile Ile Ile Asp Asn Asp Gln Asp Ile Leu Ala 
    50                  55                  60                  


Ile Lys Thr His Trp Glu Lys Val Asn Gly Asp Leu Asn Lys Thr Glu 
65                  70                  75                  80  


Arg Leu Arg Glu Leu Met Thr Lys His Phe Pro Phe Leu Glu Thr Ala 
                85                  90                  95      


Ile Tyr Thr Lys Asn Lys Glu Asp Lys Lys Glu Val Lys Gln Glu Lys 
            100                 105                 110         


Gln Ala Lys Ala Gln Ser Phe Asp Ser Leu Lys His Cys Leu Phe Leu 
        115                 120                 125             


Phe Leu Glu Lys Leu Gln Glu Ala Arg Asn Tyr Tyr Ser His Tyr Lys 
    130                 135                 140                 


Tyr Ser Glu Ser Thr Lys Glu Pro Met Leu Glu Lys Glu Leu Leu Lys 
145                 150                 155                 160 


Lys Met Tyr Asn Ile Phe Asp Asp Asn Ile Gln Leu Val Ile Lys Asp 
                165                 170                 175     


Tyr Gln His Asn Lys Asp Ile Asn Pro Asp Glu Asp Phe Lys His Leu 
            180                 185                 190         


Asp Arg Thr Glu Glu Asp Phe Asn Tyr Tyr Phe Thr Arg Asn Lys Lys 
        195                 200                 205             


Gly Asn Ile Thr Ala Ser Gly Leu Leu Phe Phe Val Ser Leu Phe Leu 
    210                 215                 220                 


Glu Lys Lys Asp Ala Ile Trp Met Gln Gln Lys Leu Arg Gly Phe Lys 
225                 230                 235                 240 


Asp Asn Arg Glu Ser Lys Lys Lys Met Thr His Glu Val Phe Cys Arg 
                245                 250                 255     


Ser Arg Met Leu Leu Pro Lys Leu Arg Leu Glu Ser Thr Gln Thr Gln 
            260                 265                 270         


Asp Trp Ile Leu Leu Asp Met Leu Asn Glu Leu Ile Arg Cys Pro Lys 
        275                 280                 285             


Ser Leu Tyr Glu Arg Leu Gln Gly Asp Asp Arg Lys Lys Phe Asn Val 
    290                 295                 300                 


Pro Phe Asp Pro Thr Asp Glu Asn Tyr Asp Ala Glu Gln Glu Pro Phe 
305                 310                 315                 320 


Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Ala Leu 
                325                 330                 335     


Arg Tyr Phe Asp Tyr Asn Glu Val Phe Ala Asn Leu Arg Phe Gln Ile 
            340                 345                 350         


Asp Leu Gly Thr Tyr His Phe Ser Ile Tyr Lys Lys Leu Ile Gly Gly 
        355                 360                 365             


Gln Lys Glu Asp Arg His Leu Thr His Lys Leu Tyr Gly Phe Glu Arg 
    370                 375                 380                 


Ile Gln Glu Phe Ala Lys Gln Asn Arg Pro Asp Glu Trp Lys Ala Ile 
385                 390                 395                 400 


Val Lys Asp Leu Asp Thr Tyr Glu Thr Ser Glu Glu Pro Tyr Ile Ser 
                405                 410                 415     


Glu Thr Thr Pro His Tyr His Leu Glu Asn Gln Lys Ile Gly Ile Arg 
            420                 425                 430         


Phe Arg Asn Gly Asn Asn Asp Ile Trp Pro Ser Leu Glu Thr Asn Gly 
        435                 440                 445             


Glu Asn Asn Glu Lys Ser Lys Tyr Lys Leu Asp Lys Gln Tyr Gln Ala 
    450                 455                 460                 


Glu Ala Phe Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr 
465                 470                 475                 480 


Leu Leu Leu Lys Lys Glu Lys Pro Asn Asn Asp Glu Ile Asn Ala Ser 
                485                 490                 495     


Ile Val Glu Gly Phe Ile Lys Arg Glu Ile Arg Tyr Ile Tyr Lys Leu 
            500                 505                 510         


Tyr Asp Ala Phe Ala Asn Gly Glu Ile Asn Asn Ile Asp Asp Leu Lys 
        515                 520                 525             


Lys Tyr Cys Glu Asp Lys Gly Ile Pro Lys Arg Asn Leu Pro Lys Gln 
    530                 535                 540                 


Met Ile Ala Ile Leu Glu Ser Lys Pro Lys Asp Met Val Glu Glu Ala 
545                 550                 555                 560 


Glu Arg Lys Gln Arg Lys Met Val Lys Asp Thr Lys Lys Leu Leu Ala 
                565                 570                 575     


Thr Leu Glu Lys Gln Thr Gln Gly Glu Ile Glu Asp Gly Gly Arg Asn 
            580                 585                 590         


Ile Arg Leu Leu Lys Ser Gly Glu Ile Ala Arg Trp Leu Val Asn Asp 
        595                 600                 605             


Met Met Arg Phe Gln Pro Val Gln Lys Asp Asn Glu Gly Asn Pro Leu 
    610                 615                 620                 


Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln Met Leu Gln Arg Ser 
625                 630                 635                 640 


Leu Ala Leu Tyr Asn Lys Glu Glu Lys Pro Thr Arg Tyr Phe Arg Gln 
                645                 650                 655     


Val Asn Leu Ile Glu Ser Ser Asn Pro His Pro Phe Leu Asn Asn Thr 
            660                 665                 670         


Glu Trp Lys Glu Cys Asn Asn Ile Leu Ser Phe Tyr Arg Ser Tyr Leu 
        675                 680                 685             


Thr Lys Lys Ile Glu Phe Leu Asn Glu Leu Lys Pro Glu Asp Trp Glu 
    690                 695                 700                 


Lys Asn Gln Tyr Phe Leu Lys Leu Lys Glu Pro Lys Thr Asn Arg Glu 
705                 710                 715                 720 


Thr Leu Val Gln Gly Trp Lys Asn Gly Phe Asn Leu Pro Arg Gly Ile 
                725                 730                 735     


Phe Thr Glu Pro Ile Arg Glu Trp Phe Lys Arg His Gln Asn Asp Ser 
            740                 745                 750         


Lys Glu Tyr Glu Lys Val Glu Ala Leu Lys Arg Val Gly Leu Val Thr 
        755                 760                 765             


Lys Val Ile Pro Leu Phe Phe Lys Glu Glu Tyr Phe Lys Glu Asp Ala 
    770                 775                 780                 


Gln Lys Glu Ile Asn Asn Cys Val Gln Pro Phe Tyr Gly Phe Pro Tyr 
785                 790                 795                 800 


Asn Val Gly Asn Ile His Lys Pro Lys Glu Glu Asp Phe Leu His Arg 
                805                 810                 815     


Glu Glu Arg Ile Glu Leu Trp Asp Lys Lys Lys Asp Lys Phe Lys Gly 
            820                 825                 830         


Tyr Lys Ala Lys Lys Lys Phe Lys Glu Met Thr Asp Lys Glu Lys Glu 
        835                 840                 845             


Glu His Arg Ser Tyr Leu Glu Phe Lys Ser Trp Asn Gln Phe Glu Arg 
    850                 855                 860                 


Glu Leu Arg Leu Val Arg Asn Gln Asp Ile Val Thr Trp Leu Leu Cys 
865                 870                 875                 880 


Met Glu Leu Ile Asp Lys Leu Lys Val Glu Gly Leu Asn Val Glu Glu 
                885                 890                 895     


Leu Gln Lys Leu Arg Leu Lys Asp Ile Asp Thr Asp Thr Ala Lys Gln 
            900                 905                 910         


Glu Lys Asn Asn Ile Leu Asn Arg Val Met Pro Met Gln Leu Pro Val 
        915                 920                 925             


Thr Val Tyr Glu Ile Asp Asp Ser His Asn Ile Val Lys Asp Arg Pro 
    930                 935                 940                 


Leu His Thr Val Tyr Ile Glu Glu Thr Lys Thr Lys Leu Leu Lys Gln 
945                 950                 955                 960 


Gly Asn Phe Lys Ala Leu Val Lys Asp Arg Arg Leu Asn Gly Leu Phe 
                965                 970                 975     


Ser Phe Val Asp Thr Ser Ser Glu Ala Glu Leu Lys Ser Asn Pro Ile 
            980                 985                 990         


Ser Lys Leu Arg Val Glu Tyr Glu  Leu Gly Glu Tyr Gln  Asn Ala Arg 
        995                 1000                 1005             


Ile Glu  Ile Ile Glu Asp Met  Leu Ala Leu Glu Gly  Ala Leu Ile 
    1010                 1015                 1020             


Glu Lys  Asp Lys Asn Leu Pro  Thr Asp Asn Phe Ser  Asp Met Leu 
    1025                 1030                 1035             


Asn Gly  Trp Leu Glu Gly Lys  Asp Glu Ser Asp Lys  Ala Arg Phe 
    1040                 1045                 1050             


Gln Asn  Asp Val Lys Leu Leu  Val Ala Val Arg Asn  Ala Phe Ser 
    1055                 1060                 1065             


His Asn  Gln Tyr Pro Met Arg  Asn Arg Ile Ala Phe  Ala Asn Ile 
    1070                 1075                 1080             


Asn Pro  Phe Ser Leu Ser Ser  Ala Asp Ile Ser Glu  Glu Lys Gly 
    1085                 1090                 1095             


Leu Asp  Ile Ala Asn Gln Leu  Lys Asp Lys Thr His  Lys Ile Ile 
    1100                 1105                 1110             


Lys Arg  Ile Ile Lys Ile Glu  Lys Pro Ile Glu Thr  Lys Glu 
    1115                 1120                 1125         


<210>  1883
<211>  1064
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1883

Met Pro Leu Tyr Tyr Pro Phe Ser Glu Lys Asp Lys His Tyr Phe Gly 
1               5                   10                  15      


Ser Tyr Leu Asn Leu Ala His Lys Asn Ile Phe Asp Val Leu Asn Glu 
            20                  25                  30          


Phe Cys Ser Arg Phe Gln Leu Lys Asn Lys Lys Pro Lys Glu Lys Glu 
        35                  40                  45              


Phe Phe Lys Asp Phe Lys Glu Leu Glu Lys Phe Leu Ile Asn Ile Phe 
    50                  55                  60                  


Lys Glu Asn Ile Ser Ile Ser Asp Tyr Glu Lys Trp Ile Glu Val Leu 
65                  70                  75                  80  


Ser Ser Tyr Phe Pro Val Val Ala Tyr Leu Asp Asn Gln Glu Lys Asn 
                85                  90                  95      


Arg Asn Lys Lys Glu Asp Arg Ile Asn Asn Phe Arg Asn Asn Phe Leu 
            100                 105                 110         


Asn Leu Ile Ser Thr Ile Asp Lys Leu Arg Asn Phe Tyr Thr His Tyr 
        115                 120                 125             


Phe His Asn Glu Val Lys Ile Glu Asp Ser Val Phe Glu Ile Leu Asp 
    130                 135                 140                 


Lys Leu Phe Glu Asn Thr Leu Leu Glu Ile Lys Asn Lys Phe Leu Lys 
145                 150                 155                 160 


Thr Asp Lys Thr Gln Glu Ala Leu Lys Lys Leu Leu Gln Lys Glu Ile 
                165                 170                 175     


Asp Thr Tyr Thr Lys Asn Asn Lys Lys Glu Glu Val Leu Lys Ser Ile 
            180                 185                 190         


Phe Glu Glu Ser Ile Asp Ile Ile Asp Glu Lys Gly Asn Leu Lys Thr 
        195                 200                 205             


Glu Cys Phe Ser Ser Lys Asn Ile Ser Gln Pro Asn Asn Asn Gly Leu 
    210                 215                 220                 


Lys Val Ser Ile Ser Leu Asp Gly Leu Val Ile Leu Leu Ser Ile Phe 
225                 230                 235                 240 


Leu Asn Lys Lys Asp Ile Asn His Phe Arg Ala Asn Ile Ser Val Pro 
                245                 250                 255     


Asp Ile Ile Lys Gly Asp Glu Glu Leu Phe Lys Lys Leu Asn Ser Thr 
            260                 265                 270         


Cys Ile Asp Arg Ile Asn Ser His Leu Ala Tyr Lys Gly Leu Lys Tyr 
        275                 280                 285             


Arg Leu Lys Thr Ser Pro Ile Leu Asp Lys Ala Val Leu Met Lys Gln 
    290                 295                 300                 


Ile Leu Asp Glu Leu Asn Lys Val Pro Asp Val Ile Tyr Lys Asn Ile 
305                 310                 315                 320 


Glu Glu Ser Lys Gln Glu Asp Phe Ile Met Asp Leu Asn Glu Tyr Phe 
                325                 330                 335     


Arg Asp Asn Gly Glu Glu Asn Gln Ser Leu Asp Asn Leu Arg Val Val 
            340                 345                 350         


His Pro Val Ile Arg Lys Arg Tyr Glu Asp Lys Phe Asn Tyr Phe Ala 
        355                 360                 365             


Leu Arg Phe Leu Asp Glu Tyr Ala Asp Phe Pro Lys Leu Arg Phe Gln 
    370                 375                 380                 


Val His Ile Gly Asn Tyr Ile His His Gln Thr Asp Lys Phe Val Gly 
385                 390                 395                 400 


Asn Ser Thr Lys Asn Arg Ile Ile Lys Glu Lys Ile Asn Val Phe Gly 
                405                 410                 415     


Lys Leu Asn Asp Ile Ile Lys Ala Lys Ala Asn Tyr Phe His Ser Ser 
            420                 425                 430         


Thr Ile Asp Thr Gln Trp Glu Glu Phe Pro Asn Pro Ser Tyr Leu Phe 
        435                 440                 445             


Pro Lys Glu Asn Ile Val Asp Asn Lys Asn Gln Asn Ala Asn Lys Ile 
    450                 455                 460                 


Gly Ile Gln Leu Pro Ile Asn Asn Pro Ile Ile Asn Asn Ile Leu Asn 
465                 470                 475                 480 


Glu Ile Pro Asn Leu Asn Gln Glu Arg Asn Pro Asn Lys Lys Glu Lys 
                485                 490                 495     


Ile Tyr Ile Val Asn Asp Val Leu Asn Ile Asn Glu Ser Asp Asn Asn 
            500                 505                 510         


Asn Ala Asn Asn Asn Asp Asn Pro Ile Ile Pro Phe Gly Ala Pro Thr 
        515                 520                 525             


Ala Tyr Leu Ser Met Asn Asp Ile His Ser Ile Leu Tyr Glu Ile Ile 
    530                 535                 540                 


Lys Asn Gly Thr Ser Gly Gln Lys Leu Glu Asn Lys Ile Arg Arg Gln 
545                 550                 555                 560 


Ile Glu Lys Gln Ile Gly Asp Ile His Asn Gln Ser Glu Gly Ile Lys 
                565                 570                 575     


Ile Leu Lys Lys Arg Ile Glu Ile Asp Asn Glu Gln Ile Asn Tyr Asn 
            580                 585                 590         


Lys Leu Lys Lys Asp Leu Glu Asn Leu Ile Asn Gln Thr Lys Asn Leu 
        595                 600                 605             


Gln Lys Glu His Gln Glu Arg Ile Asp Ser Tyr Asn Asn Lys Glu Arg 
    610                 615                 620                 


Lys Tyr Ile Leu Thr Asn Asn Glu Lys Gly Arg Ile Ala Asn Trp Leu 
625                 630                 635                 640 


Ala Asn Glu Ile Lys Gln Phe Met Pro Gln Lys Phe Lys Ser Asn Trp 
                645                 650                 655     


Lys Gly Tyr Gln His Asn Glu Leu Gln Lys Leu Leu Ala Tyr Tyr Glu 
            660                 665                 670         


Ile Ser Lys Asp Glu Val Leu Lys Leu Leu Glu Asn Ser Gly Thr Lys 
        675                 680                 685             


Glu His Phe Asn Phe Glu Lys Tyr Ser Thr Leu Glu Glu Leu Tyr Glu 
    690                 695                 700                 


Asp Tyr Leu Asn Thr Lys Ile Ser Thr Leu Ser Thr Leu Gln Gln Gln 
705                 710                 715                 720 


Leu Lys Asn Phe Glu Lys Glu Ile Phe Ile Phe Leu Asn Arg Lys Asn 
                725                 730                 735     


Tyr Ile Gln Lys Pro Ile Ser Glu Lys Ile Asn Gln Ile Leu Ser Ser 
            740                 745                 750         


Pro Ile Phe Ile Glu Arg Gly Phe Leu Asp Asn Lys Pro Thr Met Ile 
        755                 760                 765             


Glu Lys Thr Lys Phe Ala Gly Asn Glu Glu Leu Phe Ala Asp Trp Phe 
    770                 775                 780                 


Gln Phe Tyr Lys Lys Asn Lys Glu Tyr Gln Asp Phe Tyr Asn Thr Glu 
785                 790                 795                 800 


Lys Tyr Pro Leu Lys Ser Asp Leu Ser Lys Ser Glu Leu Lys Ser Ile 
                805                 810                 815     


Asn Lys Lys Ile Asn Gln Gln Lys Lys Asn Asp Val Phe Ala Leu His 
            820                 825                 830         


Met Ala Lys Glu Ile Phe Asn Asp Leu Phe Leu Thr Asn Asn Asn Leu 
        835                 840                 845             


Asp Ile Thr Leu Ser Asp Leu Phe Gly Gln Asn Ile Trp Asp Lys Thr 
    850                 855                 860                 


Leu Thr Leu Glu Leu Phe Gly Gly Lys Leu Lys Ile Lys Asn Val Lys 
865                 870                 875                 880 


Ile Lys Asp Ile Gly Lys Tyr Arg Lys Tyr Glu Asn Asp Ser Arg Val 
                885                 890                 895     


Lys Leu Leu Thr Glu Tyr Phe Pro Asp Arg Glu Trp Val Gly His Leu 
            900                 905                 910         


Pro Asn Asp Lys Asn Thr Pro Ala Tyr Asn Ser Ile Glu Arg Gln Leu 
        915                 920                 925             


Glu Glu Tyr Glu Arg Ile Arg Ser Glu Glu Leu Phe Lys Glu Val His 
    930                 935                 940                 


Lys Leu Glu Lys Glu Ile Tyr Asp Gln Val Glu Asp Lys Asn Cys Leu 
945                 950                 955                 960 


Leu Glu Ser Asn Asn Pro Asn Phe Arg Asn Tyr Ile Ile Lys Gly Phe 
                965                 970                 975     


Leu Cys Glu Ile Lys Asn Tyr Ile Lys Asp Thr Asp Thr Glu Asn Tyr 
            980                 985                 990         


Ala Lys Glu Leu Lys Glu Asp Asn  Asp Gln Asn Lys Val  Glu Asn Tyr 
        995                 1000                 1005             


Thr Tyr  Val Leu Ile Asn Ile  Arg Asn Lys Phe Ser  His Asn Gln 
    1010                 1015                 1020             


Leu Pro  Asp Leu Glu Thr Phe  Asn Tyr Cys Gln Lys  Ile Lys Glu 
    1025                 1030                 1035             


Ile Asn  Asn Asp Gln Phe Ile  Ala Lys Tyr Tyr Leu  Asp Ile Phe 
    1040                 1045                 1050             


Arg Thr  Ile Thr Glu Ile Leu  Lys Gly Asn Leu 
    1055                 1060                 


<210>  1884
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1884

Val Lys Met Glu Asp Asp Lys Lys Thr Thr Glu Ser Thr Asn Met Leu 
1               5                   10                  15      


Asp Asn Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Val Tyr Ile Thr Val Asn His Ile Asn Lys Val Leu Glu Leu Lys Asn 
        35                  40                  45              


Lys Lys Asp Gln Asp Ile Ile Ile Asp Asn Asp Gln Asp Ile Leu Ala 
    50                  55                  60                  


Ile Lys Thr Leu Trp Glu Lys Val Asn Gly Asp Leu Asn Lys Thr Glu 
65                  70                  75                  80  


Arg Leu Arg Glu Leu Met Thr Lys His Phe Pro Phe Leu Glu Thr Ala 
                85                  90                  95      


Ile Tyr Ser Lys Asn Lys Glu Asp Lys Glu Glu Val Lys Gln Glu Lys 
            100                 105                 110         


Gln Ala Lys Ala Gln Ser Phe Asp Ser Leu Lys His Cys Leu Phe Leu 
        115                 120                 125             


Phe Leu Glu Lys Leu Gln Glu Ala Arg Asn Tyr Tyr Ser His Tyr Lys 
    130                 135                 140                 


Tyr Ser Glu Ser Thr Lys Glu Pro Met Leu Glu Lys Glu Leu Leu Lys 
145                 150                 155                 160 


Lys Met Tyr Asn Ile Phe Asp Asp Asn Ile Gln Leu Val Ile Lys Asp 
                165                 170                 175     


Tyr Gln His Asn Lys Asp Ile Asn Pro Asn Glu Asp Phe Lys His Leu 
            180                 185                 190         


Asp Arg Thr Glu Glu Asp Phe Asn Tyr Tyr Phe Thr Arg Asn Lys Lys 
        195                 200                 205             


Gly Asn Ile Thr Ala Ser Gly Leu Leu Phe Phe Val Ser Leu Phe Leu 
    210                 215                 220                 


Glu Lys Lys Asp Ala Ile Trp Met Gln Gln Lys Leu Arg Gly Phe Lys 
225                 230                 235                 240 


Asp Asn Arg Glu Ser Lys Lys Lys Met Thr His Glu Val Phe Cys Arg 
                245                 250                 255     


Arg Arg Met Leu Leu Pro Lys Leu Arg Leu Glu Ser Thr Gln Thr Gln 
            260                 265                 270         


Asp Trp Ile Leu Leu Asp Met Leu Asn Glu Leu Ile Arg Cys Pro Lys 
        275                 280                 285             


Ser Leu Tyr Glu Arg Leu Gln Gly Glu Tyr Arg Lys Lys Phe Asn Val 
    290                 295                 300                 


Pro Phe Asp Pro Ala Asp Glu Asp Tyr Asp Ala Glu Gln Glu Pro Phe 
305                 310                 315                 320 


Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Val Leu 
                325                 330                 335     


Arg Tyr Phe Asp Tyr Asn Glu Ile Phe Thr Asn Leu Arg Phe Gln Ile 
            340                 345                 350         


Asp Leu Gly Thr Tyr His Phe Ser Ile Tyr Lys Lys Leu Ile Gly Gly 
        355                 360                 365             


Gln Lys Glu Asp Arg His Leu Thr His Lys Leu Tyr Gly Phe Glu Arg 
    370                 375                 380                 


Ile Gln Glu Phe Ala Lys Gln Asn Arg Thr Asp Glu Trp Lys Ala Ile 
385                 390                 395                 400 


Val Lys Asp Leu Asp Thr Tyr Glu Thr Ser Asn Glu Arg Tyr Ile Ser 
                405                 410                 415     


Glu Thr Thr Pro His Tyr His Leu Glu Asn Gln Lys Ile Gly Ile Arg 
            420                 425                 430         


Phe Arg Asn Gly Asn Asn Asp Ile Trp Pro Ser Leu Glu Thr Asn Gly 
        435                 440                 445             


Glu Asn Asn Glu Lys Ser Lys Tyr Lys Leu Asp Lys Pro Tyr Gln Ala 
    450                 455                 460                 


Glu Ala Phe Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr 
465                 470                 475                 480 


Leu Leu Leu Lys Lys Glu Glu Pro Asn Asn Asp Lys Lys Asn Ala Ser 
                485                 490                 495     


Ile Val Glu Gly Phe Ile Lys Arg Glu Ile Arg Asp Ile Tyr Lys Leu 
            500                 505                 510         


Tyr Asp Ala Phe Ala Asn Gly Glu Ile Asn Ser Glu Glu Glu Leu Lys 
        515                 520                 525             


Glu Tyr Leu Lys Gly Lys Asp Ile Glu Ile Val His Leu Pro Lys Gln 
    530                 535                 540                 


Met Ile Ala Ile Leu Glu Ser Lys Pro Lys Asp Met Val Lys Glu Ala 
545                 550                 555                 560 


Lys Arg Lys Gln Lys Glu Met Val Lys Asp Thr Lys Lys Leu Leu Ala 
                565                 570                 575     


Ala Leu Glu Lys Gln Thr Gln Glu Glu Ile Glu Asp Gly Gly Arg Asn 
            580                 585                 590         


Ile Arg Leu Leu Lys Ser Gly Glu Ile Ala Arg Trp Leu Val Asn Asp 
        595                 600                 605             


Met Met Arg Phe Gln Pro Val Gln Lys Asp Asn Glu Gly Asn Pro Leu 
    610                 615                 620                 


Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln Met Leu Gln Arg Ser 
625                 630                 635                 640 


Leu Ala Leu Tyr Asn Lys Glu Glu Lys Pro Thr Arg Tyr Phe Arg Gln 
                645                 650                 655     


Val Asn Leu Ile Asn Ser Ser Asn Pro His Pro Phe Leu Lys Trp Thr 
            660                 665                 670         


Lys Trp Glu Glu Cys Asn Asn Ile Leu Ser Phe Tyr Arg Ser Tyr Leu 
        675                 680                 685             


Thr Lys Lys Ile Glu Phe Leu Asn Lys Leu Lys Pro Glu Asp Trp Glu 
    690                 695                 700                 


Lys Asn Gln Tyr Phe Leu Lys Leu Lys Glu Pro Lys Thr Asn Arg Lys 
705                 710                 715                 720 


Thr Leu Val Gln Gly Trp Lys Asn Gly Phe Asn Leu Pro Arg Gly Ile 
                725                 730                 735     


Phe Thr Glu Pro Ile Arg Glu Trp Phe Lys Arg His Gln Asn Asp Ser 
            740                 745                 750         


Glu Glu Tyr Lys Lys Val Glu Ala Leu Lys Arg Val Gly Leu Val Ala 
        755                 760                 765             


Lys Val Ile Pro Leu Phe Phe Lys Glu Glu Tyr Phe Lys Glu Asp Ala 
    770                 775                 780                 


Gln Lys Glu Ile Asn Asn Cys Val Gln Pro Phe Tyr Ser Phe Pro Tyr 
785                 790                 795                 800 


Asn Val Gly Asn Ile His Lys Pro Asp Glu Lys Asp Phe Leu Pro Ser 
                805                 810                 815     


Glu Glu Arg Lys Lys Leu Trp Gly Asp Lys Lys Tyr Lys Phe Lys Gly 
            820                 825                 830         


Tyr Lys Ala Lys Glu Lys Ser Lys Lys Leu Thr Asp Lys Glu Lys Glu 
        835                 840                 845             


Glu Tyr Arg Ser Tyr Leu Glu Phe Gln Ser Trp Asn Lys Phe Glu Arg 
    850                 855                 860                 


Glu Leu Arg Leu Val Arg Asn Gln Asp Ile Val Thr Trp Leu Leu Cys 
865                 870                 875                 880 


Thr Glu Leu Ile Asp Lys Leu Lys Val Glu Gly Leu Asn Val Glu Glu 
                885                 890                 895     


Leu Gln Lys Leu Arg Leu Lys Asp Ile Asp Thr Asp Thr Ala Lys Lys 
            900                 905                 910         


Glu Lys Asn Asn Ile Leu Asn Arg Ile Met Pro Met Gln Leu Pro Val 
        915                 920                 925             


Thr Val Tyr Glu Ile Asp Asp Ser His Asn Ile Val Lys Asp Arg Pro 
    930                 935                 940                 


Leu His Thr Val Tyr Ile Glu Glu Thr Lys Thr Lys Leu Leu Lys Gln 
945                 950                 955                 960 


Gly Asn Phe Lys Ala Leu Val Lys Asp Arg Arg Leu Asn Gly Leu Phe 
                965                 970                 975     


Ser Phe Val Asp Thr Ser Ser Glu Ala Asp Leu Lys Asp Lys Pro Ile 
            980                 985                 990         


Ser Lys Ser Val Val Glu Tyr Glu  Leu Gly Glu Tyr Gln  Asn Ala Arg 
        995                 1000                 1005             


Ile Glu  Thr Ile Lys Asp Met  Leu Leu Leu Glu Lys  Thr Leu Ile 
    1010                 1015                 1020             


Lys Lys  Tyr Lys Lys Leu Pro  Thr Asp Asn Phe Ser  Asp Met Leu 
    1025                 1030                 1035             


Asn Gly  Trp Leu Glu Gly Lys  Asp Glu Ser Asp Lys  Ala Arg Phe 
    1040                 1045                 1050             


Gln Asn  Asp Val Lys Leu Leu  Val Ala Val Arg Asn  Ala Phe Ser 
    1055                 1060                 1065             


His Asn  Gln Tyr Pro Met Arg  Asn Arg Ile Ala Phe  Ala Asn Ile 
    1070                 1075                 1080             


Asn Pro  Phe Ser Leu Ser Ser  Ala Asn Thr Ser Glu  Glu Lys Lys 
    1085                 1090                 1095             


Leu Asp  Ile Ala Asn Gln Leu  Lys Asp Lys Thr His  Lys Thr Ile 
    1100                 1105                 1110             


Glu Lys  Ile Ile Glu Ile Glu  Lys Pro Ile Glu Thr  Lys Glu 
    1115                 1120                 1125         


<210>  1885
<211>  1123
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1885

Met Glu Asp Asp Lys Lys Thr Thr Asp Ser Ile Ser Tyr Glu Leu Lys 
1               5                   10                  15      


Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val 
            20                  25                  30          


Tyr Ile Thr Val Asn His Ile Asn Lys Ile Leu Glu Glu Gly Glu Ile 
        35                  40                  45              


Asn Arg Asp Gly Tyr Glu Asn Thr Leu Glu Lys Ser Trp Asn Glu Ile 
    50                  55                  60                  


Lys Asp Ile Asn Lys Lys Asp Arg Leu Ser Lys Leu Ile Ile Lys His 
65                  70                  75                  80  


Phe Pro Phe Leu Glu Ala Ala Thr Tyr Arg Arg Asn Pro Thr Asp Thr 
                85                  90                  95      


Thr Lys Gln Lys Glu Glu Lys Gln Ala Glu Ala Gln Ser Leu Glu Ser 
            100                 105                 110         


Leu Arg Lys Ser Phe Phe Val Phe Ile Tyr Lys Leu Arg Asp Leu Arg 
        115                 120                 125             


Asn His Tyr Ser His Tyr Lys His Ser Lys Ser Leu Glu Arg Pro Lys 
    130                 135                 140                 


Phe Glu Glu Gly Leu Gln Lys Lys Met Tyr Asn Ile Phe Asn Ala Ser 
145                 150                 155                 160 


Ile Gln Leu Val Lys Glu Asp Tyr Lys His Asn Thr Asp Ile Lys Thr 
                165                 170                 175     


Glu Glu Asp Phe Lys His Leu Asp Arg Lys Gly Gln Phe Lys Tyr Ser 
            180                 185                 190         


Phe Ala Asp Asn Glu Gly Asn Ile Thr Glu Ser Gly Leu Leu Phe Phe 
        195                 200                 205             


Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Met Gln Gln Lys 
    210                 215                 220                 


Leu Arg Gly Phe Lys Asp Asn Arg Glu Asn Lys Lys Lys Met Thr Asn 
225                 230                 235                 240 


Glu Val Phe Cys Arg Ser Arg Met Leu Leu Pro Lys Leu Arg Leu Gln 
                245                 250                 255     


Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu Asn Glu Leu 
            260                 265                 270         


Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Arg Glu Glu Asp Arg 
        275                 280                 285             


Glu Lys Phe Arg Val Pro Ile Glu Ile Ala Asp Glu Asp Tyr Asp Ala 
    290                 295                 300                 


Glu Gln Glu Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
305                 310                 315                 320 


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Tyr Asn Glu Ile Phe Gln Asn 
                325                 330                 335     


Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile Tyr Lys 
            340                 345                 350         


Lys Gln Ile Gly Asp Tyr Lys Glu Ser His His Leu Thr His Lys Leu 
        355                 360                 365             


Tyr Gly Phe Glu Arg Ile Gln Glu Phe Ala Lys Gln Asn Arg Pro Asp 
    370                 375                 380                 


Glu Trp Arg Lys Phe Val Lys Thr Phe Asn Ser Phe Glu Thr Ser Lys 
385                 390                 395                 400 


Glu Pro Tyr Ile Pro Glu Thr Thr Pro His Tyr His Leu Glu Asn Gln 
                405                 410                 415     


Lys Ile Gly Ile Arg Phe Arg Asn Asp Asn Asp Lys Ile Trp Pro Ser 
            420                 425                 430         


Leu Lys Thr Asn Ser Glu Lys Asn Glu Lys Ser Lys Tyr Lys Leu Asp 
        435                 440                 445             


Lys Ser Phe Gln Ala Glu Ala Phe Leu Ser Val His Glu Leu Leu Pro 
    450                 455                 460                 


Met Met Phe Tyr Tyr Leu Leu Leu Lys Thr Glu Asn Thr Asp Asn Asp 
465                 470                 475                 480 


Asn Glu Ile Glu Thr Lys Lys Lys Glu Asn Lys Asn Asp Lys Gln Glu 
                485                 490                 495     


Lys His Lys Ile Glu Glu Ile Ile Glu Asn Lys Ile Thr Glu Ile Tyr 
            500                 505                 510         


Ala Leu Tyr Asp Thr Phe Ala Asn Gly Glu Ile Lys Ser Ile Asp Glu 
        515                 520                 525             


Leu Glu Glu Tyr Cys Lys Gly Lys Asp Ile Glu Ile Gly His Leu Pro 
    530                 535                 540                 


Lys Gln Met Ile Thr Ile Leu Lys Ser Glu His Lys Asp Met Ala Thr 
545                 550                 555                 560 


Glu Ala Lys Arg Lys Gln Glu Glu Met Leu Ala Asp Val Gln Lys Ser 
                565                 570                 575     


Leu Glu Ser Leu Asp Asn Gln Ile Asn Glu Glu Val Glu Asn Val Glu 
            580                 585                 590         


Arg Lys Asn Ser Ser Leu Lys Ser Gly Glu Ile Ala Ser Trp Leu Val 
        595                 600                 605             


Asn Asp Met Met Arg Phe Gln Pro Val Gln Lys Asp Asn Glu Gly Asn 
    610                 615                 620                 


Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln Met Leu Gln 
625                 630                 635                 640 


Arg Ser Leu Ala Leu Tyr Asn Lys Glu Glu Lys Pro Thr Arg Tyr Phe 
                645                 650                 655     


Lys Gln Val Asn Leu Ile Glu Ser Ser Asn Pro His Pro Phe Leu Asn 
            660                 665                 670         


Asn Thr Glu Trp Lys Glu Cys Asn Asn Ile Leu Ser Phe Tyr Arg Ser 
        675                 680                 685             


Tyr Leu Thr Lys Lys Ile Glu Phe Leu Asn Glu Leu Lys Pro Glu Asp 
    690                 695                 700                 


Trp Lys Lys Asn Gln Tyr Phe Leu Lys Leu Lys Glu Pro Lys Thr Asn 
705                 710                 715                 720 


Arg Glu Thr Leu Val Gln Gly Trp Lys Asn Gly Phe Asn Leu Pro Arg 
                725                 730                 735     


Gly Ile Phe Thr Glu Pro Ile Arg Lys Trp Phe Met Glu His Trp Lys 
            740                 745                 750         


Ser Ile Lys Val Asp Asp Leu Lys Arg Val Gly Leu Val Ala Lys Val 
        755                 760                 765             


Ile Pro Leu Phe Phe Ser Glu Lys Tyr Lys Asp Ser Val Gln Pro Phe 
    770                 775                 780                 


Tyr Asn Tyr Leu Phe Asn Val Gly Asn Ile Asn Lys Pro Asp Glu Lys 
785                 790                 795                 800 


Asn Phe Leu Asn Cys Glu Lys Arg Arg Glu Gln Leu Arg Lys Lys Lys 
                805                 810                 815     


Asp Glu Phe Lys Lys Met Thr Asp Lys Glu Lys Glu Glu Asn Pro Ser 
            820                 825                 830         


Tyr Leu Glu Phe Gln Ser Trp Asn Lys Phe Glu Arg Glu Leu Arg Leu 
        835                 840                 845             


Val Arg Asn Gln Asp Ile Val Thr Trp Leu Leu Cys Met Glu Leu Phe 
    850                 855                 860                 


Asn Lys Lys Lys Ile Lys Glu Leu Asn Val Glu Lys Ile Tyr Leu Lys 
865                 870                 875                 880 


Asp Ile Asn Thr Asn Thr Thr Lys Lys Glu Lys Asn Thr Glu Glu Lys 
                885                 890                 895     


Asn Gly Glu Glu Lys Ile Ile Lys Glu Lys Asn Asn Ile Leu Asn Arg 
            900                 905                 910         


Ile Met Pro Met Arg Leu Pro Ile Lys Val Tyr Gly Arg Glu Asn Phe 
        915                 920                 925             


Ser Lys Asn Lys Lys Lys Lys Ile Arg Arg Asn Thr Phe Phe Thr Val 
    930                 935                 940                 


Tyr Ile Glu Glu Lys Gly Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys 
945                 950                 955                 960 


Ala Leu Glu Arg Asp Arg Arg Leu Gly Gly Leu Phe Ser Phe Val Lys 
                965                 970                 975     


Thr Pro Ser Lys Ala Glu Ser Lys Ser Asn Thr Ile Ser Lys Leu Arg 
            980                 985                 990         


Val Glu Tyr Glu Leu Gly Glu Tyr  Gln Lys Ala Arg Ile  Glu Ile Ile 
        995                 1000                 1005             


Lys Asp  Met Leu Ala Leu Glu  Lys Thr Leu Ile Asp  Lys Tyr Asn 
    1010                 1015                 1020             


Ser Leu  Asp Thr Asp Asn Phe  Asn Lys Met Leu Thr  Asp Trp Leu 
    1025                 1030                 1035             


Glu Leu  Lys Gly Glu Pro Asp  Lys Ala Ser Phe Gln  Asn Asp Val 
    1040                 1045                 1050             


Asp Leu  Leu Ile Ala Val Arg  Asn Ala Phe Ser His  Asn Gln Tyr 
    1055                 1060                 1065             


Pro Met  Arg Asn Arg Ile Ala  Phe Ala Asn Ile Asn  Pro Phe Ser 
    1070                 1075                 1080             


Leu Ser  Ser Ala Asn Thr Ser  Glu Glu Lys Gly Leu  Gly Ile Ala 
    1085                 1090                 1095             


Asn Gln  Leu Lys Asn Lys Thr  His Lys Thr Ile Glu  Lys Ile Ile 
    1100                 1105                 1110             


Glu Ile  Glu Lys Pro Ile Glu  Thr Lys Glu 
    1115                 1120             


<210>  1886
<211>  1085
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1886

Met Lys Lys Glu Leu Asn Arg Glu Asp Val Phe Thr Gly Gly Lys Thr 
1               5                   10                  15      


Pro Glu Leu Thr Ile Tyr Tyr Asn Ile Ala Tyr Phe Arg Met Ala Gly 
            20                  25                  30          


Leu Ile Asn Ala Leu Cys Gly Asn Lys Leu Glu Arg Asp Lys Asp Ala 
        35                  40                  45              


Leu Glu Gln Phe Met Lys Ala Phe Ile Asn Gly Lys Gln Lys Leu Thr 
    50                  55                  60                  


Asp Met Gln Phe Val Lys Leu Cys Asp Tyr Leu Trp Lys Gly Tyr Lys 
65                  70                  75                  80  


Tyr Asp Lys Asn Arg Ser Glu Tyr Ser Leu Thr Glu Asn Asp Lys Thr 
                85                  90                  95      


Met Val Leu Lys Met Val Ala Lys Leu Gln Asp Ile Arg Asn Phe Gln 
            100                 105                 110         


Ser His Ile Trp His Asp Asn Lys Val Leu Val Phe Asp Ala Asp Leu 
        115                 120                 125             


Val Gln Phe Ile Lys Asn Lys His Leu Glu Ala Ile Asp Ala Gln Arg 
    130                 135                 140                 


Gln Arg Phe Ser Lys Glu Thr Glu Val Tyr Glu Lys Glu Asn Arg Glu 
145                 150                 155                 160 


Leu Lys Lys Lys Lys Asn Lys Glu Leu Leu Phe Asp Ile His Asp Gly 
                165                 170                 175     


Leu Gly Tyr Ile Thr Gly Glu Gly Arg Asn Phe Phe Leu Ser Phe Phe 
            180                 185                 190         


Leu Thr Arg Gly Glu Met Thr Arg Phe Leu Lys Gln Arg Lys Gly Cys 
        195                 200                 205             


Lys Arg Asp Asp Thr Pro Glu Tyr Lys Ile Lys His Leu Val Tyr Arg 
    210                 215                 220                 


His Phe Thr His Arg Asp Gly Ala Thr Arg Thr His Tyr Gly Tyr Glu 
225                 230                 235                 240 


Asp Asn Met Leu Asp Gln Leu Pro Asp Lys Gln Glu Phe Leu Thr Thr 
                245                 250                 255     


Arg His Thr Tyr Arg Leu Ile Asn Tyr Leu Asn Asp Ile Pro Glu Glu 
            260                 265                 270         


Val Thr Asn Pro Glu Leu Phe Pro Leu Phe Asn Thr Ile Ser Asn Gly 
        275                 280                 285             


Ile Leu Ile Lys Glu Ser Val Gly Thr Tyr Ile Ala Phe Ile Asn Lys 
    290                 295                 300                 


Met Pro Leu Leu Ser Asp Phe Glu Phe Ser Glu Val Trp Gly Lys Asp 
305                 310                 315                 320 


Gly Lys Pro Tyr Thr Asn Leu Val Glu Phe Tyr His Lys Thr Gln Pro 
                325                 330                 335     


Gly Phe Lys Phe Arg Thr Asp Leu Asn Ser Phe His Lys Ile Ile Leu 
            340                 345                 350         


Asn Leu Ile Arg Asp Glu Asn Tyr Thr Gly Phe Phe Thr Thr Gln Leu 
        355                 360                 365             


Asn Leu Phe Met Ala His Arg Glu Glu Leu Ile Leu Val Ile Ser Lys 
    370                 375                 380                 


Pro Leu Ile Thr Pro Asn Asp Leu Leu Leu Ile Glu Glu His Tyr Arg 
385                 390                 395                 400 


Tyr Lys Leu Lys Ala Asn Asp Phe Val Arg Glu Lys Leu Gly Glu Trp 
                405                 410                 415     


Lys Glu Lys Ile Glu Lys Gly Lys Trp Glu Lys Ala Asn Glu Gln Lys 
            420                 425                 430         


Asp Lys Leu Ile Asn Leu Leu Gly Gly Val Ile Glu Ile Thr Phe Tyr 
        435                 440                 445             


Asp Phe Tyr Trp Gln Lys Asp Glu Lys Pro Arg Asn Glu Asn Arg Phe 
    450                 455                 460                 


Met Glu Phe Ala Ile Arg Phe Met Ala Asp Phe Asn Leu Leu Pro Asp 
465                 470                 475                 480 


Cys Glu Trp Glu Val Glu Pro Leu Gln Ile Glu Asn Asp Leu Ile Ala 
                485                 490                 495     


Asn Arg Thr Ala Thr Pro Asp Leu Lys Lys Ser Gly Ser Gln Phe Met 
            500                 505                 510         


Asn Gln Leu Thr Asp Asn Tyr Arg Leu Lys Phe Asn Asp Gly Gln Ile 
        515                 520                 525             


Ala Phe Arg Tyr Gln Asn Gln Val Phe Ile Met Gly His Lys Ala Val 
    530                 535                 540                 


Lys Asn Leu Leu Ile Ala Cys Phe Asp Gly Lys Glu Lys Met Leu Asn 
545                 550                 555                 560 


Gly Phe Met Pro Ala Leu Leu Ala Asp Leu Lys Lys Ile Thr Asn Glu 
                565                 570                 575     


His Ile Leu Lys Asn His Gln Ala Leu Asn Thr Leu Ser Leu Leu Asn 
            580                 585                 590         


Asn Asp Ser Ile Pro Ser Tyr Ile Ser Arg Gln Trp Gly Glu Ala Glu 
        595                 600                 605             


Pro Ile Thr Asp Met Lys Lys Lys Ala Ile Ala Arg Met Asp Tyr Ile 
    610                 615                 620                 


Thr Gln Gln Phe Glu Ala Leu Ile Glu Asn His His Tyr Leu Asn Arg 
625                 630                 635                 640 


Ala Asp Lys Asn Arg Gln Ile Met Arg Cys Tyr Lys Phe Phe Glu Trp 
                645                 650                 655     


Gln Tyr Pro Gln Asn Ser Gln Phe Lys Phe Leu Arg Arg Asn Glu Tyr 
            660                 665                 670         


His Arg Met Ser Ile Tyr His Tyr Cys Leu Asp Lys Glu Gln His Lys 
        675                 680                 685             


Tyr Asp Lys Lys Gly His Asn Tyr Leu Tyr Asn Arg Leu Ile Lys Glu 
    690                 695                 700                 


Ser His Asn Glu Ser Gly Asn Ile Glu Gln His Leu Pro Tyr Gln Ile 
705                 710                 715                 720 


Arg Thr Met Leu Asn Asp Ala Lys Asp Phe Asn Asp Tyr Phe Leu Arg 
                725                 730                 735     


Ile Leu Asn Ala Thr His Lys Ile Leu Thr Asp Trp Lys Asn Gln Leu 
            740                 745                 750         


Lys Gln Gly Arg Glu Pro Asn Asn Tyr Tyr Leu Ser Arg Leu Gly Phe 
        755                 760                 765             


Thr Gly Gly Leu Thr Gln Lys Val Val His Thr Arg Leu Leu Pro Phe 
    770                 775                 780                 


Ser Ile His Pro Gly Ile Pro Val Ser Phe Phe Tyr Arg Thr Glu Met 
785                 790                 795                 800 


Asn Gln Asn Pro Ser Phe Asn Leu Ser Ala Lys Val Trp Asn Ser Glu 
                805                 810                 815     


Ser Pro Phe Arg Val Gly Leu Lys Glu Ser Asn Tyr Gln Tyr Ala Lys 
            820                 825                 830         


Tyr Leu Gly Leu Phe Asn Glu Ile Lys Thr Gln Arg Lys Ile Ile Gly 
        835                 840                 845             


Lys Met Asn Gln Leu Ile Ala Glu Asp Ala Leu Leu Trp Gln Ile Ala 
    850                 855                 860                 


Lys Lys Tyr Leu Asp Lys Cys His Pro Lys Phe Ser Glu Ile Ile Asn 
865                 870                 875                 880 


Gln Gln Val Asn Gly Lys Gln Pro Leu Asn Val Lys Ala Ile His Asp 
                885                 890                 895     


Thr Glu Leu Thr Ile Asp Phe Pro Val Asp Lys Asn Leu Tyr Gln Val 
            900                 905                 910         


Val Val Lys Met Lys Gln Leu Asp Asp Phe Met Phe Ile Asp Ser Lys 
        915                 920                 925             


Pro Val Leu Glu Lys Thr Ile Arg Tyr Met Ile Lys Asn Ser Leu Arg 
    930                 935                 940                 


Asp Lys Glu Tyr Gln Gln Arg Val Phe Ile Glu Thr Asn Pro Gly Val 
945                 950                 955                 960 


Phe Lys Ile Pro Tyr Asn Glu Val Val Glu Ala Met Arg Thr Ile Asn 
                965                 970                 975     


His Gln Ala Leu Thr Trp Ala Arg Leu Leu Leu Asp Trp Glu Ser Lys 
            980                 985                 990         


Thr Val Lys Thr Ile Pro Glu Ala  Asp Lys Lys Ala Lys  Leu Gln Glu 
        995                 1000                 1005             


Ala Tyr  Asn Lys Arg Gln Pro  Ala Phe Phe Asn Phe  Asn Asp Ile 
    1010                 1015                 1020             


Cys Arg  Tyr Ala Asp Asp Gly  Lys Gln Leu Lys Asp  Leu Arg Asn 
    1025                 1030                 1035             


Lys Thr  Phe His Thr Glu Val  Pro Glu Thr Trp Thr  Tyr Asp Glu 
    1040                 1045                 1050             


Met Arg  Glu Asn Lys Thr Ile  Lys Met Val Leu Gly  Ile Asn Glu 
    1055                 1060                 1065             


Thr Thr  Phe Leu Lys Lys Asp  Tyr Ala Ile Glu Asn  Ala Arg Thr 
    1070                 1075                 1080             


Ile Glu  
    1085 


<210>  1887
<211>  964
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (948)..(959)
<223>  Xaa can be any naturally occurring amino acid

<400>  1887

Met Lys Lys Glu Leu Asn Arg Glu Asp Val Phe Thr Gly Gly Lys Thr 
1               5                   10                  15      


Pro Glu Leu Thr Ile Tyr Tyr Asn Ile Ala Tyr Phe Arg Met Ala Gly 
            20                  25                  30          


Leu Ile Asn Ala Leu Cys Gly Asn Lys Leu Glu Arg Asp Lys Asp Ala 
        35                  40                  45              


Leu Glu Gln Phe Met Lys Ala Phe Ile Asn Gly Lys Gln Lys Leu Thr 
    50                  55                  60                  


Asp Met Gln Phe Val Lys Leu Cys Asp Tyr Leu Trp Lys Gly Tyr Lys 
65                  70                  75                  80  


Tyr Asp Lys Asn Arg Ser Glu Tyr Ser Leu Thr Glu Asn Asp Lys Thr 
                85                  90                  95      


Met Val Leu Lys Met Val Ala Lys Leu Gln Asp Ile Arg Asn Phe Gln 
            100                 105                 110         


Ser His Ile Trp His Asp Asn Lys Val Leu Val Phe Asp Ala Asp Leu 
        115                 120                 125             


Val Gln Phe Ile Lys Asn Lys His Leu Glu Ala Ile Asp Ala Gln Arg 
    130                 135                 140                 


Gln Arg Phe Ser Lys Glu Thr Glu Val Tyr Glu Lys Glu Asn Arg Glu 
145                 150                 155                 160 


Leu Lys Lys Lys Lys Asn Lys Glu Leu Leu Phe Asp Ile His Asp Gly 
                165                 170                 175     


Leu Gly Tyr Ile Thr Gly Glu Gly Arg Asn Phe Phe Leu Ser Phe Phe 
            180                 185                 190         


Leu Thr Arg Gly Glu Met Thr Arg Phe Leu Lys Gln Arg Lys Gly Cys 
        195                 200                 205             


Lys Arg Asp Asp Thr Pro Glu Tyr Lys Ile Lys His Leu Val Tyr Arg 
    210                 215                 220                 


His Phe Thr His Arg Asp Gly Ala Thr Arg Thr His Tyr Gly Tyr Glu 
225                 230                 235                 240 


Asp Asn Met Leu Asp Gln Leu Pro Asp Lys Gln Glu Phe Leu Thr Thr 
                245                 250                 255     


Arg His Thr Tyr Arg Leu Ile Asn Tyr Leu Asn Asp Ile Pro Glu Glu 
            260                 265                 270         


Val Thr Asn Pro Glu Leu Phe Pro Leu Phe Asn Thr Ile Ser Asn Gly 
        275                 280                 285             


Ile Leu Ile Lys Glu Ser Val Gly Thr Tyr Ile Ala Phe Ile Asn Lys 
    290                 295                 300                 


Met Pro Leu Leu Ser Asp Phe Glu Phe Ser Glu Val Trp Gly Lys Asp 
305                 310                 315                 320 


Gly Lys Pro Tyr Thr Asn Leu Val Glu Phe Tyr His Lys Thr Gln Pro 
                325                 330                 335     


Gly Phe Lys Phe Arg Thr Asp Leu Asn Ser Phe His Lys Ile Ile Leu 
            340                 345                 350         


Asn Leu Ile Arg Asp Glu Asn Tyr Thr Gly Phe Phe Thr Thr Gln Leu 
        355                 360                 365             


Asn Leu Phe Met Ala His Arg Glu Glu Leu Ile Leu Val Ile Ser Lys 
    370                 375                 380                 


Pro Leu Ile Thr Pro Asn Asp Leu Leu Leu Ile Glu Glu His Tyr Arg 
385                 390                 395                 400 


Tyr Lys Leu Lys Ala Asn Asp Phe Val Arg Glu Lys Leu Gly Glu Trp 
                405                 410                 415     


Lys Glu Lys Ile Glu Lys Gly Lys Trp Glu Lys Ala Asn Glu Gln Lys 
            420                 425                 430         


Asp Lys Leu Ile Asn Leu Leu Gly Gly Val Ile Glu Ile Thr Phe Tyr 
        435                 440                 445             


Asp Phe Tyr Trp Gln Lys Asp Glu Lys Pro Arg Asn Glu Asn Arg Phe 
    450                 455                 460                 


Met Glu Phe Ala Ile Arg Phe Met Ala Asp Phe Asn Leu Leu Pro Asp 
465                 470                 475                 480 


Cys Glu Trp Glu Val Glu Pro Leu Gln Ile Glu Asn Asp Leu Ile Ala 
                485                 490                 495     


Asn Arg Thr Ala Thr Pro Asp Leu Lys Lys Ser Gly Ser Gln Phe Met 
            500                 505                 510         


Asn Gln Leu Thr Asp Asn Tyr Arg Leu Lys Phe Asn Asp Gly Gln Ile 
        515                 520                 525             


Ala Phe Arg Tyr Gln Asn Gln Val Phe Ile Met Gly His Lys Ala Val 
    530                 535                 540                 


Lys Asn Leu Leu Ile Ala Cys Phe Asp Gly Lys Glu Lys Met Leu Asn 
545                 550                 555                 560 


Gly Phe Met Pro Ala Leu Leu Ala Asp Leu Lys Lys Ile Thr Asn Glu 
                565                 570                 575     


His Ile Leu Lys Asn His Gln Ala Leu Asn Thr Leu Ser Leu Leu Asn 
            580                 585                 590         


Asn Asp Ser Ile Pro Ser Tyr Ile Ser Arg Gln Trp Gly Glu Ala Glu 
        595                 600                 605             


Pro Ile Thr Asp Met Lys Lys Lys Ala Ile Ala Arg Met Asp Tyr Ile 
    610                 615                 620                 


Thr Gln Gln Phe Glu Ala Leu Ile Glu Asn His His Tyr Leu Asn Arg 
625                 630                 635                 640 


Ala Asp Lys Asn Arg Gln Ile Met Arg Cys Tyr Lys Phe Phe Glu Trp 
                645                 650                 655     


Gln Tyr Pro Gln Asn Ser Gln Phe Lys Phe Leu Arg Arg Asn Glu Tyr 
            660                 665                 670         


His Arg Met Ser Ile Tyr His Tyr Cys Leu Asp Lys Glu Gln His Lys 
        675                 680                 685             


Tyr Asp Lys Lys Gly His Asn Tyr Leu Tyr Asn Arg Leu Ile Lys Glu 
    690                 695                 700                 


Ser His Asn Glu Ser Gly Asn Ile Glu Gln His Leu Pro Tyr Gln Ile 
705                 710                 715                 720 


Arg Thr Met Leu Asn Asp Ala Lys Asp Phe Asn Asp Tyr Phe Leu Arg 
                725                 730                 735     


Ile Leu Asn Ala Thr His Lys Ile Leu Thr Asp Trp Lys Asn Gln Leu 
            740                 745                 750         


Lys Gln Gly Arg Glu Pro Asn Asn Tyr Tyr Leu Ser Arg Leu Gly Phe 
        755                 760                 765             


Thr Gly Gly Leu Thr Gln Lys Val Val His Thr Arg Leu Leu Pro Phe 
    770                 775                 780                 


Ser Ile His Pro Gly Ile Pro Val Ser Phe Phe Tyr Arg Thr Glu Met 
785                 790                 795                 800 


Asn Gln Asn Pro Ser Phe Asn Leu Ser Ala Lys Val Trp Asn Ser Glu 
                805                 810                 815     


Ser Pro Phe Arg Val Gly Leu Lys Glu Ser Asn Tyr Gln Tyr Ala Lys 
            820                 825                 830         


Tyr Leu Gly Leu Phe Asn Glu Ile Lys Thr Gln Arg Lys Ile Ile Gly 
        835                 840                 845             


Lys Met Asn Gln Leu Ile Ala Glu Asp Ala Leu Leu Trp Gln Ile Ala 
    850                 855                 860                 


Lys Lys Tyr Leu Asp Lys Cys His Pro Lys Phe Ser Glu Ile Ile Asn 
865                 870                 875                 880 


Gln Gln Val Asn Gly Lys Gln Pro Leu Asn Val Lys Ala Ile His Asp 
                885                 890                 895     


Thr Glu Leu Thr Ile Asp Phe Pro Val Asp Lys Asn Leu Tyr Gln Val 
            900                 905                 910         


Val Val Lys Met Lys Gln Leu Asp Asp Phe Met Phe Ile Asp Ser Lys 
        915                 920                 925             


Pro Val Leu Glu Lys Thr Ile Arg Tyr Met Ile Lys Asn Ser Leu Arg 
    930                 935                 940                 


Asp Lys Glu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu 
945                 950                 955                 960 


Gln Arg Ser Gly 
                


<210>  1888
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1888

Met Gly Ala Ile Lys Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1889
<211>  1146
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1889

Met Glu Ser Ile Ile Gly Leu Gly Leu Ser Phe Asn Pro Tyr Lys Thr 
1               5                   10                  15      


Ala Asp Lys His Tyr Phe Gly Ser Phe Leu Asn Leu Ala Asp Asn Asn 
            20                  25                  30          


Leu Lys Ala Val Phe Ala Glu Phe Lys Glu Arg Ile Ser Asp Lys Ser 
        35                  40                  45              


Lys Asp Glu Asp Ile Ser Asn Leu Ile Glu Lys His Phe Ile Asp Asn 
    50                  55                  60                  


Met Ser Ile Val Asp Tyr Glu Lys Asn Ile Ser Ile Leu Asn Gly Tyr 
65                  70                  75                  80  


Leu Pro Ile Ile Asp Phe Leu Asp Asp Glu Leu Glu Asn Asn Leu Asn 
                85                  90                  95      


Thr Arg Val Lys Asn Phe Lys Lys Ser Phe Ile Ile Leu Ala Glu Ala 
            100                 105                 110         


Leu Glu Thr Leu Arg Asn Tyr Tyr Thr His Phe Tyr His Asp Pro Ile 
        115                 120                 125             


Thr Phe Gly Asp Asn Lys Glu Pro Leu Leu Glu Leu Leu Asp Glu Val 
    130                 135                 140                 


Leu Leu Lys Thr Ile Leu Asp Val Lys Lys Lys Tyr Leu Lys Thr Asp 
145                 150                 155                 160 


Lys Thr Lys Glu Ile Leu Lys Asp Ser Leu Arg Glu Glu Met Asp Leu 
                165                 170                 175     


Leu Val Ile Arg Lys Thr Asp Glu Leu Arg Glu Lys Lys Lys Thr Asn 
            180                 185                 190         


Pro Lys Phe Lys Phe Ser Thr Asp Pro Thr Gln Ile Arg Asn Ser Ile 
        195                 200                 205             


Phe Asn Asp Ala Phe Gln Gly Leu Leu Tyr Glu Asp Lys Glu Asn Asn 
    210                 215                 220                 


Gly Lys Thr Gln Val Ser Tyr Arg Ala Lys Thr Lys Leu Asn Pro Lys 
225                 230                 235                 240 


Asp Ile His Lys Gln Glu Glu Arg Asp Phe Glu Ile Pro Leu Ser Thr 
                245                 250                 255     


Ser Gly Ile Val Phe Leu Met Ser Leu Phe Leu Ser Lys Lys Glu Ile 
            260                 265                 270         


Glu Asp Phe Lys Ser Asn Ile Lys Gly Phe Lys Gly Lys Val Val Lys 
        275                 280                 285             


Asp Glu Asn His Asn Ser Leu Lys Tyr Met Ala Thr His Arg Val Tyr 
    290                 295                 300                 


Ser Ile Leu Ala Phe Lys Gly Leu Lys Tyr Arg Ile Lys Thr Asp Thr 
305                 310                 315                 320 


Phe Ser Lys Val Thr Leu Met Met Gln Met Ile Asp Glu Leu Ser Lys 
                325                 330                 335     


Val Pro Asp Cys Val Tyr Gln Asn Leu Ser Glu Thr Lys Gln Lys Asp 
            340                 345                 350         


Phe Ile Glu Asp Trp Asn Glu Tyr Leu Lys Asp Asn Glu Glu Asn Thr 
        355                 360                 365             


Glu Asn Leu Glu Asn Ser Arg Val Val His Pro Leu Ile Arg Lys Arg 
    370                 375                 380                 


Tyr Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe 
385                 390                 395                 400 


Ala Asn Phe Lys Thr Leu Lys Phe Gln Val Phe Met Gly Tyr Tyr Ile 
                405                 410                 415     


His Asp Gln Arg Thr Lys Thr Ile Gly Thr Thr Asn Ile Thr Thr Glu 
            420                 425                 430         


Arg Thr Val Lys Glu Lys Ile Asn Val Phe Gly Lys Leu Ser Lys Met 
        435                 440                 445             


Asp Asn Leu Lys Lys His Phe Phe Ser Gln Leu Ser Asp Glu Glu Asn 
    450                 455                 460                 


Thr Asp Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Phe Leu Thr Gln 
465                 470                 475                 480 


Ala Asp Asn Ser Pro Ala Asn Asn Ile Pro Ile Tyr Leu Glu Leu Lys 
                485                 490                 495     


Asn Gln Gln Ile Ile Lys Glu Lys Asp Asp Ile Lys Ala Glu Val Asn 
            500                 505                 510         


Asn Ser Gln Asn Arg Asn Pro Asn Lys Pro Ser Lys Arg Asp Leu Leu 
        515                 520                 525             


Asn Lys Ile Ser Asn Thr Asn Glu Asp Phe Tyr Gln Gly Asp Pro Thr 
    530                 535                 540                 


Ala Ile Leu Ser Leu Asn Glu Ile Pro Ala Leu Leu His Leu Phe Leu 
545                 550                 555                 560 


Val Gln Pro Asp Asn Lys Thr Gly Gln Gln Ile Glu Asn Ile Ile Arg 
                565                 570                 575     


Ile Lys Ile Glu Lys Gln Phe Asn Ser Ile Lys Asn Pro Ser Lys Asp 
            580                 585                 590         


Asp Lys Gly Val Pro Lys Ser Leu Phe Ala Asp Thr Asn Val Arg Val 
        595                 600                 605             


Asn Ala Ile Lys Leu Lys Lys Asp Leu Gly Glu Glu Leu Asp Met Leu 
    610                 615                 620                 


Asn Lys Lys Gln Ile Val Phe Lys Glu Asn Gln Lys Ala Ser Ser Asn 
625                 630                 635                 640 


Tyr Asp Glu Leu Leu Lys Lys His Gln Phe Thr Pro Lys Asn Lys Arg 
                645                 650                 655     


Pro Ala Leu Arg Lys Tyr Val Phe Tyr Asn Ser Glu Lys Gly Glu Glu 
            660                 665                 670         


Ala Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Lys Gly Phe 
        675                 680                 685             


Lys Thr Lys Trp Lys Gly Tyr Gln His Ser Glu Leu Gln Arg Lys Leu 
    690                 695                 700                 


Ala Phe Tyr Asp Arg His Thr Lys Gln Asp Ile Lys Glu Leu Leu Ser 
705                 710                 715                 720 


Gly Cys Glu Phe Asp His Phe Leu Leu Asp Ile Asn Ala Cys Phe Lys 
                725                 730                 735     


Glu Asp Asp Phe Glu Asp Phe Phe Ser Lys Tyr Leu Lys Asn Arg Ile 
            740                 745                 750         


Glu Thr Leu Asn Ile Ile Leu Lys Gln Leu His Asp Phe Lys Asn Glu 
        755                 760                 765             


Pro Thr Pro Leu Lys Gly Val Phe Lys Asn Cys Leu Lys Phe Leu Lys 
    770                 775                 780                 


Gln Lys Asn Tyr Val Thr Glu Asn Pro Glu Ile Ile Lys Lys Arg Ile 
785                 790                 795                 800 


Leu Ala Lys Pro Ala Phe Leu Pro Arg Gly Ile Phe Asp Glu Arg Pro 
                805                 810                 815     


Thr Met Lys Lys Gly Lys Asn Pro Leu Ile Asp Arg Asp Glu Phe Ala 
            820                 825                 830         


Lys Trp Phe Val Glu Tyr Leu Glu Asn Lys Asp Tyr Gln Lys Phe Tyr 
        835                 840                 845             


Asn Ser Glu Glu Tyr Arg Ile Arg Asp Ala Asp Phe Lys Lys Asn Ala 
    850                 855                 860                 


Val Ile Lys Lys Gln Lys Leu Lys Asp Phe Tyr Thr Leu Gln Met Val 
865                 870                 875                 880 


Asn Tyr Leu Leu Lys Glu Val Phe Gly Lys Asp Glu Met Asn Leu Gln 
                885                 890                 895     


Leu Ser Glu Leu Phe Gln Thr Arg Gln Glu Arg Leu Lys Leu Gln Gly 
            900                 905                 910         


Ile Ala Lys Lys Gln Met Asn Lys Glu Thr Gly Asp Ser Ser Glu Asn 
        915                 920                 925             


Thr Arg Asn Gln Thr Tyr Ile Trp Asn Lys Asp Val Pro Val Ser Phe 
    930                 935                 940                 


Phe Asn Gly Lys Val Thr Ile Asp Lys Val Lys Leu Lys Asn Ile Gly 
945                 950                 955                 960 


Lys Tyr Lys Arg Tyr Glu Arg Asp Glu Arg Val Lys Thr Phe Ile Gly 
                965                 970                 975     


Tyr Glu Val Asp Glu Lys Trp Met Met Tyr Leu Pro His Asn Trp Lys 
            980                 985                 990         


Asp Arg Tyr Ser Val Lys Pro Ile  Asn Leu Ile Asp Leu  Gln Ile Gln 
        995                 1000                 1005             


Glu Tyr  Glu Glu Ile Arg Ser  His Glu Leu Leu Lys  Glu Ile Gln 
    1010                 1015                 1020             


Asn Leu  Glu Gln Tyr Ile Tyr  Asp His Thr Thr Asp  Lys Asn Thr 
    1025                 1030                 1035             


Leu Leu  Gln Asp Gly Asn Pro  Asn Phe Lys Met Tyr  Val Leu Asn 
    1040                 1045                 1050             


Gly Leu  Leu Thr Gly Ile Lys  Gln Val Asn Ile Ala  Asp Phe Ile 
    1055                 1060                 1065             


Val Leu  Lys Gln Asn Thr Asn  Phe Asp Lys Ile Asp  Phe Thr Gly 
    1070                 1075                 1080             


Ile Ala  Ser Cys Ser Glu Leu  Glu Lys Lys Thr Ile  Ile Leu Ile 
    1085                 1090                 1095             


Ala Ile  Arg Asn Lys Phe Ser  His Asn Gln Leu Pro  Asn Lys Thr 
    1100                 1105                 1110             


Ile Tyr  Asp Leu Ala Asn Glu  Phe Leu Lys Lys Glu  Lys Arg Glu 
    1115                 1120                 1125             


Thr Tyr  Ala Asn Tyr Tyr Leu  Lys Val Leu Lys Lys  Met Ile Ser 
    1130                 1135                 1140             


Asp Leu  Ala 
    1145     


<210>  1890
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1890

Met Gly Ala Ile Lys Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Gly Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1891
<211>  1085
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1891

Met Lys Lys Glu Leu Asn Arg Glu Asp Val Phe Thr Gly Gly Lys Thr 
1               5                   10                  15      


Pro Glu Leu Thr Ile Tyr Tyr Asn Ile Ala Tyr Phe Arg Met Ala Gly 
            20                  25                  30          


Leu Ile Asn Ala Leu Cys Gly Asn Lys Leu Glu Arg Asp Lys Asp Ala 
        35                  40                  45              


Leu Glu Gln Phe Met Lys Ala Phe Ile Asn Gly Lys Gln Lys Leu Thr 
    50                  55                  60                  


Asp Met Gln Phe Val Lys Leu Cys Asp Tyr Leu Trp Lys Gly Tyr Lys 
65                  70                  75                  80  


Tyr Asp Lys Asn Arg Ser Glu Tyr Ser Leu Thr Glu Asn Asp Lys Thr 
                85                  90                  95      


Met Val Leu Lys Met Val Ala Lys Leu Gln Asp Ile Arg Asn Phe Gln 
            100                 105                 110         


Ser His Ile Trp His Asp Asn Lys Val Leu Val Phe Asp Ala Asp Leu 
        115                 120                 125             


Val Gln Phe Ile Lys Asn Lys His Leu Glu Ala Ile Asp Ala Gln Arg 
    130                 135                 140                 


Gln Arg Phe Ser Lys Glu Thr Glu Val Tyr Glu Lys Glu Asn Arg Glu 
145                 150                 155                 160 


Leu Lys Lys Lys Lys Asn Lys Glu Leu Leu Phe Asp Ile His Asp Gly 
                165                 170                 175     


Leu Gly Tyr Ile Thr Gly Glu Gly Arg Asn Phe Phe Leu Ser Phe Phe 
            180                 185                 190         


Leu Thr Arg Gly Glu Met Thr Arg Phe Leu Lys Gln Arg Lys Gly Cys 
        195                 200                 205             


Lys Arg Asp Asp Thr Pro Glu Tyr Lys Ile Lys His Leu Val Tyr Arg 
    210                 215                 220                 


His Phe Thr His Arg Asp Gly Ala Thr Arg Thr His Tyr Gly Tyr Glu 
225                 230                 235                 240 


Asp Asn Met Leu Asp Gln Leu Pro Asp Lys Gln Glu Phe Leu Thr Thr 
                245                 250                 255     


Arg His Thr Tyr Arg Leu Ile Asn Tyr Leu Asn Asp Ile Pro Glu Glu 
            260                 265                 270         


Val Thr Asn Pro Glu Leu Phe Pro Leu Phe Asn Thr Ile Ser Asn Gly 
        275                 280                 285             


Ile Leu Ile Lys Glu Ser Val Gly Thr Tyr Ile Ala Phe Ile Asn Lys 
    290                 295                 300                 


Met Pro Leu Leu Ser Asp Phe Glu Phe Ser Glu Val Trp Gly Lys Asp 
305                 310                 315                 320 


Gly Lys Pro Tyr Thr Asn Leu Val Glu Phe Tyr His Lys Thr Gln Pro 
                325                 330                 335     


Gly Phe Lys Phe Arg Thr Asp Leu Asn Ser Phe His Lys Ile Ile Leu 
            340                 345                 350         


Asn Leu Ile Arg Asp Glu Asn Tyr Thr Gly Phe Phe Thr Thr Gln Leu 
        355                 360                 365             


Asn Leu Phe Met Ala His Arg Glu Glu Leu Ile Leu Val Ile Ser Lys 
    370                 375                 380                 


Pro Leu Ile Thr Pro Asn Asp Leu Leu Leu Ile Glu Glu His Tyr Arg 
385                 390                 395                 400 


Tyr Lys Leu Lys Ala Asn Asp Phe Val Arg Glu Lys Leu Gly Glu Trp 
                405                 410                 415     


Lys Glu Lys Ile Glu Lys Gly Lys Trp Glu Lys Ala Asn Glu Gln Lys 
            420                 425                 430         


Asp Lys Leu Ile Asn Leu Leu Gly Gly Val Ile Glu Ile Thr Phe Tyr 
        435                 440                 445             


Asp Phe Tyr Trp Gln Lys Asp Glu Lys Pro Arg Asn Glu Asn Arg Phe 
    450                 455                 460                 


Met Glu Phe Ala Ile Arg Phe Met Ala Asp Phe Asn Leu Leu Pro Asp 
465                 470                 475                 480 


Cys Glu Trp Glu Val Glu Pro Leu Gln Ile Glu Asn Asp Leu Ile Ala 
                485                 490                 495     


Asn Arg Thr Ala Thr Pro Asp Leu Lys Lys Ser Gly Ser Gln Phe Met 
            500                 505                 510         


Asn Gln Leu Thr Asp Asn Tyr Arg Leu Lys Phe Asn Asp Gly Gln Ile 
        515                 520                 525             


Ala Phe Arg Tyr Gln Asn Gln Val Phe Ile Met Gly His Lys Ala Val 
    530                 535                 540                 


Lys Asn Leu Leu Ile Ala Cys Phe Asp Gly Lys Glu Lys Met Leu Asn 
545                 550                 555                 560 


Gly Phe Met Pro Ala Leu Leu Ala Asp Leu Lys Lys Ile Thr Asn Glu 
                565                 570                 575     


His Ile Leu Lys Asn His Gln Ala Leu Asn Thr Leu Ser Leu Leu Asn 
            580                 585                 590         


Asn Asp Ser Ile Pro Ser Tyr Ile Ser Arg Gln Trp Gly Glu Ala Glu 
        595                 600                 605             


Pro Ile Thr Asp Met Lys Lys Lys Ala Ile Ala Arg Met Asp Tyr Ile 
    610                 615                 620                 


Thr Gln Gln Phe Glu Ala Leu Ile Glu Asn His His Tyr Leu Asn Arg 
625                 630                 635                 640 


Ala Asp Lys Asn Arg Gln Ile Met Arg Cys Tyr Lys Phe Phe Glu Trp 
                645                 650                 655     


Gln Tyr Pro Gln Asn Ser Gln Phe Lys Phe Leu Arg Arg Asn Glu Tyr 
            660                 665                 670         


His Arg Met Ser Ile Tyr His Tyr Cys Leu Asp Lys Glu Gln His Lys 
        675                 680                 685             


Tyr Asp Lys Lys Gly His Asn Tyr Leu Tyr Asn Arg Leu Ile Lys Glu 
    690                 695                 700                 


Ser His Asn Glu Ser Gly Asn Ile Glu Gln His Leu Pro Tyr Gln Ile 
705                 710                 715                 720 


Arg Thr Met Leu Asn Asp Ala Lys Asp Phe Asn Asp Tyr Phe Leu Arg 
                725                 730                 735     


Ile Leu Asn Ala Thr His Lys Ile Leu Thr Asp Trp Lys Asn Gln Leu 
            740                 745                 750         


Lys Gln Gly Arg Glu Pro Asn Asn Tyr Tyr Leu Ser Arg Leu Gly Phe 
        755                 760                 765             


Thr Gly Gly Leu Thr Gln Lys Val Val His Thr Arg Leu Leu Pro Phe 
    770                 775                 780                 


Ser Ile His Pro Gly Ile Pro Val Ser Phe Phe Tyr Arg Thr Glu Met 
785                 790                 795                 800 


Asn Gln Asn Pro Ser Phe Asn Leu Ser Ala Lys Val Trp Asn Ser Glu 
                805                 810                 815     


Ser Pro Phe Arg Val Gly Leu Lys Glu Ser Asn Tyr Gln Tyr Ala Lys 
            820                 825                 830         


Tyr Leu Gly Leu Phe Asn Glu Ile Lys Thr Gln Arg Lys Ile Ile Gly 
        835                 840                 845             


Lys Met Asn Gln Leu Ile Ala Glu Asp Ala Leu Leu Trp Gln Ile Ala 
    850                 855                 860                 


Lys Lys Tyr Leu Asp Lys Cys His Pro Lys Phe Ser Glu Ile Ile Asn 
865                 870                 875                 880 


Gln Gln Val Asn Gly Lys Gln Pro Leu Asn Val Lys Ala Ile His Asp 
                885                 890                 895     


Thr Glu Leu Thr Ile Asp Phe Pro Val Asp Lys Asn Leu Tyr Gln Val 
            900                 905                 910         


Val Val Lys Met Lys Gln Leu Asp Asp Phe Met Phe Ile Asp Ser Lys 
        915                 920                 925             


Pro Val Leu Glu Lys Thr Ile Arg Tyr Met Ile Lys Asn Ser Leu Arg 
    930                 935                 940                 


Asp Lys Glu Tyr Gln Gln Arg Val Phe Ile Glu Thr Asn Pro Gly Val 
945                 950                 955                 960 


Phe Lys Ile Pro Tyr Asn Glu Val Val Glu Ala Met Arg Thr Ile Asn 
                965                 970                 975     


His Gln Ala Leu Thr Trp Ala Arg Leu Leu Leu Asp Trp Glu Ser Lys 
            980                 985                 990         


Thr Val Lys Thr Ile Pro Glu Ala  Asp Lys Lys Ala Lys  Leu Gln Glu 
        995                 1000                 1005             


Ala Tyr  Asn Lys Arg Gln Pro  Ala Phe Phe Asn Phe  Asn Asp Ile 
    1010                 1015                 1020             


Cys Arg  Tyr Ala Asp Asp Gly  Lys Gln Leu Lys Asp  Leu Arg Asn 
    1025                 1030                 1035             


Lys Thr  Phe His Thr Glu Val  Pro Glu Thr Trp Thr  Tyr Asp Glu 
    1040                 1045                 1050             


Met Arg  Glu Asn Lys Thr Ile  Lys Met Val Leu Gly  Ile Asn Glu 
    1055                 1060                 1065             


Thr Thr  Phe Leu Lys Lys Asp  Tyr Ala Ile Glu Asn  Ala Arg Thr 
    1070                 1075                 1080             


Ile Glu  
    1085 


<210>  1892
<211>  1171
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1892

Met Asn Leu Leu Glu Lys Thr Asn Ala Ala Glu Ser Cys Phe Asn His 
1               5                   10                  15      


Thr Ile Asn Asp Gln Lys Tyr Tyr Phe Ala Gly Tyr Leu Asn Leu Ala 
            20                  25                  30          


Gln Asn Asn Ile Lys Thr Leu Glu Lys Ala Tyr Gly Glu His Phe Leu 
        35                  40                  45              


Cys Ser Gly Asn Asn Pro Ile Ile Asn Asp Leu Thr Asn Thr Asn Ser 
    50                  55                  60                  


Leu Ile Asp Trp Asp Phe Lys Met Lys Phe Leu Ser Gln Tyr Leu Pro 
65                  70                  75                  80  


Ala Ile Ser Tyr Leu Asn Leu Glu Thr Asp Leu Asn Glu Ser Phe Glu 
                85                  90                  95      


Lys Arg Lys Lys Glu Phe Thr Lys Asn Leu Ser Phe Leu Phe Asn Ala 
            100                 105                 110         


Ile Asp Leu Leu Arg Asn Phe Tyr Ser His Tyr Tyr His Ala Pro Leu 
        115                 120                 125             


Ile Asp Glu Leu Asn Ser Glu Arg Leu Ile Phe Leu Asp Lys Ile Phe 
    130                 135                 140                 


Val Ala Val Cys Ile Asn Val Lys Lys Lys Arg Met Lys Asp Asp Lys 
145                 150                 155                 160 


Thr Lys Gln Leu Leu Lys Ala Thr Leu Ile Asp Glu Leu Asp Leu Leu 
                165                 170                 175     


Leu Lys Ala Lys Lys Glu Glu Leu Leu Lys Lys Lys Lys Glu Gly Lys 
            180                 185                 190         


Lys Val Ser Thr Asp Ala Ile Ser Met Lys Asn Ser Val Leu Asn Asp 
        195                 200                 205             


Ala Phe Asn His Leu Ile Gln Leu Glu Lys Asn Ser Lys Lys Glu Ile 
    210                 215                 220                 


Pro Gly Arg Tyr Tyr Thr Ser Leu Leu Asn Asp Asn Asn Lys Tyr Thr 
225                 230                 235                 240 


Glu Asn Gly Ile Asn Ile Ser Ile Ser Gly Leu Leu Phe Leu Leu Ser 
                245                 250                 255     


Met Phe Leu Thr Lys Lys Gln Asn Glu Asp Val Arg Ser Arg Ile Phe 
            260                 265                 270         


Gly Phe Lys Gly Thr Ile Glu Ser Asp Lys Gly Ile Ser Lys Ser Asn 
        275                 280                 285             


Asn Ser Phe Arg Asn Met Ala Thr Asn Trp Val Phe Ser Tyr Leu Ser 
    290                 295                 300                 


Phe Lys Gly Met Lys Lys Gln Leu Gly Ser Thr Phe Asn Lys Glu Ser 
305                 310                 315                 320 


Leu Leu Val Gln Ile Val Asp Glu Leu Ser Lys Val Pro His Glu Val 
                325                 330                 335     


Tyr Gln Thr Leu Ser Pro Ser Arg Gln Glu Met Phe Leu Glu Asp Met 
            340                 345                 350         


Asn Glu Tyr Leu Lys Asp Gly Asn Lys Lys His Cys Leu Glu Asp Ser 
        355                 360                 365             


Ile Val Val His Pro Val Ile Lys Lys Arg Tyr Glu Asp Lys Phe Asn 
    370                 375                 380                 


Tyr Phe Ala Ile Arg Tyr Leu Asp Glu Phe Val Asp Phe Pro Ser Leu 
385                 390                 395                 400 


Arg Phe Gln Val Asn Val Gly Asn Tyr Val His Asp Arg Arg Lys Lys 
                405                 410                 415     


Thr Ile Asp Gly Thr Asn Thr Glu Thr Asp Arg Met Val Lys Glu Glu 
            420                 425                 430         


Ile Arg Ala Phe Gly Lys Leu Ser Phe Ile Ser Lys Leu Lys Ala Asp 
        435                 440                 445             


Tyr Phe Ala Lys Asp Leu Pro Ser Asp Ile Ser Trp Glu Met Tyr Pro 
    450                 455                 460                 


Asn Pro Ser Tyr Asn Phe Ser Ala Asn Asn Ile Pro Val Tyr Ile Asp 
465                 470                 475                 480 


Leu Phe Lys Ser Ser Val Ala Gly Ala Ala Asp Val Gly Lys Asp His 
                485                 490                 495     


Lys Gly Tyr Gln Ala Lys Leu Asp Leu Asp Glu Asp Gly Lys Lys Arg 
            500                 505                 510         


Asn Arg Asn Glu Gly Lys Pro Asp Lys Lys Glu Ile Ala Glu Ile Leu 
        515                 520                 525             


Phe Gly Lys Lys Asn Lys Gln Ile Leu Phe Glu Lys Pro Thr Val Leu 
    530                 535                 540                 


Leu Ser Leu Asn Glu Leu Pro Ala Met Leu Tyr Glu Val Leu Ile Glu 
545                 550                 555                 560 


Asn Gly Asp Lys Gln Asp Ile Gly Lys Arg Ile Glu Asp Lys Ile Val 
                565                 570                 575     


Glu Lys Ile Ile Ala His Tyr Asn Leu Leu Asp Gln Tyr Asp Gly Thr 
            580                 585                 590         


Thr Glu Leu Pro Gly Ser Val Ile Pro Arg Lys Leu Arg Met Gly Gly 
        595                 600                 605             


Asn Glu Lys Ser Ile Asn Ile Asp Lys Leu Leu Arg Ala Val Lys Arg 
    610                 615                 620                 


Glu Leu Glu Ile Thr Gln Glu Lys Leu Asp Leu Ile Lys Thr Asn Gln 
625                 630                 635                 640 


Lys Lys Phe Lys Ser Lys Glu Lys Asp Glu Lys Gly Asn Ser Arg Gln 
                645                 650                 655     


His Val Phe Tyr Thr Asn Glu Leu Gly Gln Glu Ala Thr Trp Ile Ala 
            660                 665                 670         


Asn Asp Met Lys Arg Phe Met Pro Lys Glu Val Lys Glu Lys Trp Arg 
        675                 680                 685             


Gly Tyr His His Ser Asn Leu Gln Lys Leu Leu Ala Leu Tyr Asp Gln 
    690                 695                 700                 


Thr Arg Asn Glu Ala Val Lys Cys Ile Thr Cys Phe Trp Asn Phe Asp 
705                 710                 715                 720 


Gln Gln Thr Ser Trp Gly Lys Gly Ile Lys Glu Ala Phe Tyr Lys Ser 
                725                 730                 735     


Thr Phe Glu Glu Phe Tyr Lys Ala Tyr Leu Glu His Arg Met Asp Val 
            740                 745                 750         


Tyr Lys Thr Leu Glu Asn Asn Leu Ile Ala Gly Lys Gly Tyr Ser Lys 
        755                 760                 765             


Leu Phe Asn Lys Glu Lys Lys Lys Ala Phe Ile Leu Phe Asp Glu His 
    770                 775                 780                 


Leu Tyr Thr Ile Pro Asp Ile Asn Thr Gln Lys Glu Arg Leu Lys Ser 
785                 790                 795                 800 


Thr Leu Phe Ile Leu Pro Arg Gly Ile Phe Asp Ser Lys Pro Thr Phe 
                805                 810                 815     


Ile Lys Gly Ile Lys Tyr Glu Glu Asp Pro Ser Cys Phe Ala Asp Trp 
            820                 825                 830         


Tyr Gln Phe Ala Asn Ala Thr Gly Asn Gln Tyr Gln Arg Phe Tyr Asp 
        835                 840                 845             


Leu Pro Arg Ser Tyr Thr Ser Leu Phe Glu Glu Thr Lys Lys Asn Asn 
    850                 855                 860                 


Glu Gly Leu Ile Glu Asn Lys Lys Gly Leu Ser Ala Lys Glu Gln Leu 
865                 870                 875                 880 


Asp Phe Phe Lys Met Arg Gln Asp Leu Lys Ile Lys Lys Ile Lys Thr 
                885                 890                 895     


Gln Asp Leu Phe Leu Phe Met Ile Val Arg Asp Leu Tyr Lys Lys Val 
            900                 905                 910         


Phe Asp His Thr Leu Pro Leu Glu Ile Gly Leu Arg Asp Met Tyr Gln 
        915                 920                 925             


Thr Pro Ala Glu Arg Gln Ala Asn Tyr Asp Leu Ala Val Lys Gln Ser 
    930                 935                 940                 


Gln Arg Thr Glu Gly Asp Asn Ser Asp Asn Leu Tyr Asn Tyr Asn Phe 
945                 950                 955                 960 


Leu Trp Asn Leu Thr Ile Pro Phe Glu Tyr Asp Lys Ile Lys Glu Pro 
                965                 970                 975     


Gln Val Lys Leu Lys Asp Val Gly Lys Phe Tyr Lys Phe Ala Ala Asp 
            980                 985                 990         


Glu Lys Val Gln Thr Ile Leu Ser  Tyr Ser Asp Arg Glu  Trp Ser Lys 
        995                 1000                 1005             


Leu Asp  Leu Glu Lys Glu Leu  Glu Leu Met Pro Thr  Ser Tyr Glu 
    1010                 1015                 1020             


Val Ile  Arg Arg Glu Gln Leu  Leu Arg Asp Ile Gln  Gln Phe Glu 
    1025                 1030                 1035             


Lys Arg  Ile Leu Glu Asn Tyr  Pro Ser Asp Gly Asn  Ala His Pro 
    1040                 1045                 1050             


Ala Asp  Leu Glu Lys Glu Asp  Lys Asp Lys Lys Cys  Phe Pro Asn 
    1055                 1060                 1065             


Phe Asn  Leu Tyr Leu Leu Lys  Gly Ile Ile Ile Lys  Asn Asn Leu 
    1070                 1075                 1080             


Ala Ser  Glu Glu Glu Arg Gln  Trp Phe Glu Gln Val  His Leu Asp 
    1085                 1090                 1095             


Lys Thr  Pro Phe Tyr Pro Glu  Val Glu Thr Lys Ser  Ser Ile Ile 
    1100                 1105                 1110             


Gln Ser  Ala Tyr Leu Leu Leu  Leu Ile Arg Asn Lys  Met Leu His 
    1115                 1120                 1125             


Asn Gln  Leu Pro Ser Lys Gln  Asn Phe Glu Phe Met  Thr Thr Leu 
    1130                 1135                 1140             


Tyr Pro  Phe Glu Gly Tyr Glu  Ser Tyr Ser Thr Tyr  Leu Leu Phe 
    1145                 1150                 1155             


Val Thr  Lys Lys Thr Ile Glu  Cys Leu Ser Ser Ala  Met 
    1160                 1165                 1170     


<210>  1893
<211>  1132
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1893

Met Glu Asp Asp Lys Lys Thr Lys Glu Ser Thr Asn Met Leu Asp Asn 
1               5                   10                  15      


Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val Tyr 
            20                  25                  30          


Ile Thr Val Asn His Ile Asn Lys Val Leu Glu Leu Lys Asn Lys Lys 
        35                  40                  45              


Asp Gln Asp Ile Ile Ile Asp Asn Asp Gln Asp Ile Leu Ala Ile Lys 
    50                  55                  60                  


Thr His Trp Glu Lys Val Asn Gly Asp Leu Asn Lys Thr Glu Arg Leu 
65                  70                  75                  80  


Arg Glu Leu Met Thr Lys His Phe Pro Phe Leu Glu Thr Ala Ile Tyr 
                85                  90                  95      


Thr Lys Asn Lys Glu Asp Lys Glu Glu Val Lys Gln Glu Lys Gln Ala 
            100                 105                 110         


Lys Ala Gln Ser Phe Asp Ser Leu Lys His Cys Leu Phe Leu Phe Leu 
        115                 120                 125             


Glu Lys Leu Gln Glu Ala Arg Asn Tyr Tyr Ser His Tyr Lys Tyr Ser 
    130                 135                 140                 


Glu Ser Thr Lys Glu Pro Met Leu Glu Lys Glu Leu Leu Lys Lys Met 
145                 150                 155                 160 


Tyr Asn Ile Phe Asp Asp Asn Ile Gln Leu Val Ile Lys Asp Tyr Gln 
                165                 170                 175     


His Asn Lys Asp Ile Asn Pro Asp Glu Asp Phe Lys His Leu Asp Arg 
            180                 185                 190         


Thr Glu Glu Glu Phe Asn Tyr Tyr Phe Thr Arg Asn Lys Lys Gly Asn 
        195                 200                 205             


Ile Thr Ala Ser Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys 
    210                 215                 220                 


Lys Asp Ala Ile Trp Met Gln Gln Lys Leu Arg Gly Phe Lys Asp Asn 
225                 230                 235                 240 


Arg Glu Ser Lys Lys Lys Met Thr His Glu Val Phe Cys Arg Ser Arg 
                245                 250                 255     


Met Leu Leu Pro Lys Leu Arg Leu Glu Ser Thr Gln Thr Gln Asp Trp 
            260                 265                 270         


Ile Leu Leu Asp Met Leu Asn Glu Leu Ile Arg Cys Pro Lys Ser Leu 
        275                 280                 285             


Tyr Glu Arg Leu Gln Gly Asp Asp Arg Glu Lys Phe Arg Val Pro Ile 
    290                 295                 300                 


Glu Ile Ala Asp Glu Asp Tyr Asp Ala Glu Gln Glu Pro Phe Lys Asn 
305                 310                 315                 320 


Thr Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr 
                325                 330                 335     


Phe Asp Tyr Asn Glu Ile Phe Thr Asn Leu Arg Phe Gln Ile Asp Leu 
            340                 345                 350         


Gly Thr Tyr His Phe Ser Ile Tyr Lys Lys Leu Ile Gly Gly Gln Lys 
        355                 360                 365             


Glu Asp Arg His Leu Thr His Lys Leu Tyr Gly Phe Glu Arg Ile Gln 
    370                 375                 380                 


Glu Phe Asn Lys Gln Asn Arg Pro Asp Glu Trp Lys Ala Leu Val Lys 
385                 390                 395                 400 


Asp Leu Asp Thr Tyr Glu Thr Ser Asn Glu Arg Tyr Ile Ser Glu Thr 
                405                 410                 415     


Thr Pro His Tyr His Leu Glu Asn Gln Lys Ile Gly Ile Arg Phe Arg 
            420                 425                 430         


Asn Gly Asn Asn Asp Ile Trp Pro Ser Leu Glu Thr Asn Gly Glu Asn 
        435                 440                 445             


Asn Glu Lys Arg Lys Tyr Lys Leu Asp Lys Gln Tyr Gln Ala Glu Ala 
    450                 455                 460                 


Phe Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu 
465                 470                 475                 480 


Leu Lys Lys Glu Glu Pro Asn Asn Asp Lys Lys Asn Ala Ser Ile Val 
                485                 490                 495     


Glu Gly Phe Ile Lys Arg Glu Ile Arg Asp Ile Tyr Lys Leu Tyr Asp 
            500                 505                 510         


Ala Phe Ala Asn Gly Glu Ile Asn Asn Ile Asp Asp Leu Lys Lys Tyr 
        515                 520                 525             


Cys Glu Leu Lys Gly Ile Pro Lys Arg Asn Leu Pro Lys Gln Met Ile 
    530                 535                 540                 


Ala Ile Leu Lys Asn Lys Pro Lys Asp Met Val Lys Lys Ala Lys His 
545                 550                 555                 560 


Lys Gln Lys Lys Met Val Lys Ala Ala Glu Arg Lys Gln Arg Lys Met 
                565                 570                 575     


Val Lys Glu Thr Glu Lys Leu Leu Ala Ala Leu Glu Lys Gln Thr Gln 
            580                 585                 590         


Glu Glu Ile Glu Asp Gly Gly Arg Asn Ile Arg Leu Leu Lys Ser Gly 
        595                 600                 605             


Glu Ile Ala Arg Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Val 
    610                 615                 620                 


Gln Lys Asp Asn Glu Gly Asn Pro Leu Asn Asn Ser Lys Ala Asn Ser 
625                 630                 635                 640 


Thr Glu Tyr Gln Met Leu Gln Arg Ser Leu Ala Leu Tyr Asn Lys Glu 
                645                 650                 655     


Glu Lys Pro Thr Arg Tyr Phe Arg Gln Val Asn Leu Ile Glu Ser Gly 
            660                 665                 670         


Asn Pro His Pro Phe Leu Asn Asn Thr Gly Trp Lys Glu Cys Asn Asn 
        675                 680                 685             


Ile Leu Ser Phe Tyr Arg Ser Tyr Leu Thr Lys Lys Ile Glu Phe Leu 
    690                 695                 700                 


Asn Glu Leu Lys Pro Glu Asp Trp Glu Lys Asn Gln Tyr Phe Leu Lys 
705                 710                 715                 720 


Leu Lys Glu Pro Lys Thr Asn Arg Lys Thr Leu Val Gln Gly Trp Lys 
                725                 730                 735     


Asn Gly Phe Asn Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg Glu 
            740                 745                 750         


Trp Phe Lys Arg His Gln Asn Asp Ser Glu Glu Tyr Lys Lys Val Glu 
        755                 760                 765             


Ala Leu Asp Arg Val Gly Leu Val Ala Lys Val Ile Pro Leu Phe Phe 
    770                 775                 780                 


Lys Glu Glu Asp Ser Lys Asp Lys Glu Glu Tyr Leu Lys Lys Asp Ala 
785                 790                 795                 800 


Gln Lys Glu Ile Asn Asn Cys Val Gln Pro Phe Tyr Ser Phe Pro Tyr 
                805                 810                 815     


Asn Val Gly Asn Ile His Lys Pro Lys Glu Glu Asp Phe Leu His Arg 
            820                 825                 830         


Glu Glu Arg Ile Glu Gln Trp Gly Lys Lys Lys Tyr Asn Phe Lys Gly 
        835                 840                 845             


Tyr Lys Ala Lys Val Lys Ser Lys Lys Leu Thr Asp Lys Glu Lys Glu 
    850                 855                 860                 


Glu Tyr Arg Ser Tyr Leu Glu Phe Gln Ser Trp Asn Lys Phe Glu Arg 
865                 870                 875                 880 


Glu Leu Arg Leu Val Arg Asn Gln Asp Ile Val Thr Trp Leu Leu Cys 
                885                 890                 895     


Thr Glu Leu Ile Asp Lys Leu Lys Val Glu Gly Leu Asn Val Glu Glu 
            900                 905                 910         


Leu Gln Lys Leu Gly Leu Lys Asp Ile Asp Thr Asp Thr Ala Lys Gln 
        915                 920                 925             


Glu Lys Asn Asn Ile Leu Asn Arg Ile Met Pro Met Gln Leu Pro Val 
    930                 935                 940                 


Thr Val Tyr Glu Ile Asp Asp Ser His Asn Ile Val Lys Asp Arg Pro 
945                 950                 955                 960 


Leu His Thr Val Tyr Ile Glu Glu Thr Lys Thr Lys Leu Leu Lys Gln 
                965                 970                 975     


Gly Asn Phe Lys Ala Leu Val Lys Asp Arg Arg Leu Asn Gly Leu Phe 
            980                 985                 990         


Ser Phe Val Asp Thr Ser Ser Glu  Ala Glu Leu Lys Ser  Asn Pro Ile 
        995                 1000                 1005             


Ser Lys  Ser Leu Val Glu Tyr  Glu Leu Gly Glu Tyr  Gln Asn Ala 
    1010                 1015                 1020             


Arg Ile  Glu Ile Ile Glu Asp  Met Leu Ala Leu Glu  Gly Thr Leu 
    1025                 1030                 1035             


Ile Glu  Lys Asp Lys Asn Leu  Pro Thr Asp Asn Phe  Ser Asp Met 
    1040                 1045                 1050             


Leu Lys  Gly Trp Leu Lys Gly  Lys Asn Asp Ala Asp  Lys Glu Glu 
    1055                 1060                 1065             


Ser Glu  Lys Ala Ile Asp Phe  Leu Val Ala Val Arg  Asn Ala Phe 
    1070                 1075                 1080             


Ser His  Asn Gln Tyr Pro Met  Tyr Asn Ser Glu Val  Phe Glu Gly 
    1085                 1090                 1095             


Met Lys  Leu Leu Asn Pro Ser  Ser Ala Glu Phe Lys  Asp Lys Glu 
    1100                 1105                 1110             


Leu Gly  Ile Ala Asn Gln Leu  Lys Lys Lys Val Lys  Glu Ala Ile 
    1115                 1120                 1125             


Glu Lys  Ile Asn 
    1130         


<210>  1894
<211>  1162
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1894

Met Glu Lys Thr Leu Ile Ser Ser Gly Ile Tyr Tyr Asp His Thr Lys 
1               5                   10                  15      


Leu Gln Asp Lys Tyr Phe Phe Gly Gly Phe Phe Asn Leu Ala Gln Asn 
            20                  25                  30          


Asn Ile Asp Asn Val Ile Lys Ala Phe Ile Ile Lys Phe Phe Pro Glu 
        35                  40                  45              


Arg Lys Asp Gln Asn Ile Asn Thr Ala Gln Phe Leu Asp Ile Cys Phe 
    50                  55                  60                  


Lys Asp Asn Asp Ala Asp Ser Asp Phe Leu Lys Lys Asn Lys Phe Leu 
65                  70                  75                  80  


Lys Met His Phe Pro Val Ile Gly Phe Leu Ile Ser Asp Asn Asp Lys 
                85                  90                  95      


Ile Gly Phe Lys Arg Lys Phe Ser Leu Leu Leu Lys Ala Ile Ser Glu 
            100                 105                 110         


Leu Arg Asn Phe Tyr Thr His Tyr Tyr His Lys Pro Ile Glu Phe Ser 
        115                 120                 125             


Ser Glu Leu Phe Glu Ile Leu Asp Ala Ile Phe Val Lys Thr Thr Asn 
    130                 135                 140                 


Glu Ile Lys Lys Leu Lys Lys Lys Asp Asp Lys Thr Gln Gln Leu Leu 
145                 150                 155                 160 


Asn Lys Asn Leu Ser Glu Glu Tyr Lys Ile Arg Tyr Gln Gln Gln Ile 
                165                 170                 175     


Gln Arg Leu Lys Glu Leu Lys Ala Gln Gly Lys Arg Ile Gln Leu Asn 
            180                 185                 190         


Asp Glu Thr Ala Ile Arg Asn Gly Val Phe Asn Ala Ala Phe Asn His 
        195                 200                 205             


Leu Val Tyr Arg Asp Gly Glu Asn Ile Lys Pro Ser Arg Phe Tyr Gln 
    210                 215                 220                 


Ser Phe Tyr Ser Glu Ala Glu Thr Ala Glu Asn Lys Ile Pro Phe Ser 
225                 230                 235                 240 


Gln Ser Ser Ile Leu Phe Leu Leu Ser Met Phe Leu Glu Arg Lys Glu 
                245                 250                 255     


Met Glu Asp Leu Lys Ser Arg Val Lys Gly Phe Lys Ala Lys Ile Ile 
            260                 265                 270         


Lys Gln Gly Glu Glu Gln Ile Ser Gly Leu Lys Phe Met Ala Thr His 
        275                 280                 285             


Trp Val Phe Ser Tyr Leu Cys Phe Lys Gly Ile Gln Gln Lys Leu Ser 
    290                 295                 300                 


Thr Glu Phe His Glu Glu Thr Leu Leu Ile Gln Ile Ile Asp Glu Leu 
305                 310                 315                 320 


Ser Lys Val Pro Asp Glu Val Tyr Ser Ala Phe Asp Leu Glu Thr Lys 
                325                 330                 335     


Glu Arg Phe Val Glu Asp Ile Asn Glu Tyr Met Lys Glu Gly Asn Ala 
            340                 345                 350         


Asp Leu Ser Leu Glu Asp Ser Lys Val Ile His Pro Val Ile Arg Lys 
        355                 360                 365             


Arg Tyr Glu Asn Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu 
    370                 375                 380                 


Tyr Leu Ser Ser Thr Ser Leu Lys Phe Gln Val His Val Gly Asn Tyr 
385                 390                 395                 400 


Val His Asp Arg Arg Ile Lys Asp Ile Asn Gly Thr Asn Phe Gln Thr 
                405                 410                 415     


Glu Arg Ile Val Lys Asp Arg Ile Lys Val Phe Gly Arg Leu Ser Lys 
            420                 425                 430         


Ile Ser Asn Leu Lys Ala Asp Tyr Ile Lys Glu Gln Leu Glu Leu Pro 
        435                 440                 445             


Asn Asp Ser Asn Gly Trp Glu Ile Phe Pro Asn Pro Ser Tyr Ala Phe 
    450                 455                 460                 


Ile Asp Asn Asn Ile Pro Met His Ile Leu Ala Asp Glu Thr Thr Lys 
465                 470                 475                 480 


Lys Gly Ile Asp Leu Phe Lys Asp Lys Arg Arg Lys Glu Gln Pro Glu 
                485                 490                 495     


Glu Leu Gln Lys Arg Lys Gly Lys Leu Ser Lys Tyr Asn Ile Val Ser 
            500                 505                 510         


Met Ile Ser Lys Glu Ala Lys Gly Val Asp Arg Leu Arg Ile Asp Glu 
        515                 520                 525             


Pro Val Ala Leu Leu Ser Leu Asn Glu Ile Pro Ala Leu Leu Tyr Gln 
    530                 535                 540                 


Ile Leu Glu Lys Gly Ala Thr Pro Lys Asp Ile Glu Leu Ile Ile Lys 
545                 550                 555                 560 


Asn Lys Leu Thr Glu Arg Phe Glu Lys Ile Lys Asn Tyr Asp Pro Glu 
                565                 570                 575     


Thr Pro Ala Pro Ala Ser Gln Ile Ser Lys Arg Leu Arg Asn Asn Thr 
            580                 585                 590         


Thr Ala Lys Gly Gln Glu Thr Leu Asn Ala Glu Lys Leu Ser Leu Leu 
        595                 600                 605             


Ile Glu Arg Glu Ile Glu Asp Thr Glu Thr Lys Leu Ser Ser Ile Lys 
    610                 615                 620                 


Glu Lys Arg Leu Lys Ala Lys Met Glu Gln Arg Arg Asn Ser Pro Lys 
625                 630                 635                 640 


Thr Ser Ile Phe Ser Asn Ser Asp Leu Gly Arg Ile Ala Ala Trp Leu 
                645                 650                 655     


Ala Asp Asp Ile Lys Arg Phe Met Pro Thr Glu Gln Arg Lys Asn Trp 
            660                 665                 670         


Lys Gly Tyr Gln His Ser Gln Leu Gln Gln Ser Leu Ala Tyr Phe Glu 
        675                 680                 685             


Lys Arg Pro Gln Glu Ala Phe Leu Leu Leu Lys Glu Gly Trp Asp Thr 
    690                 695                 700                 


Ser Asp Gly Ser Ser Cys Trp Asn Asn Trp Val Ile Asn Ser Phe Ser 
705                 710                 715                 720 


Glu Thr Lys Asp Phe Glu Lys Phe Tyr Glu Asn Tyr Leu Arg Lys Arg 
                725                 730                 735     


Ala Ile Tyr Phe Ser Glu Leu Ala Glu Asn Ile Lys Gln His Thr His 
            740                 745                 750         


Asn Thr Lys Phe Leu Arg Lys Phe Ile Lys Gln Gln Met Pro Ala Asp 
        755                 760                 765             


Leu Phe Pro Lys Lys His Tyr Ile Leu Lys Asp Leu Glu Thr Glu Lys 
    770                 775                 780                 


Asn Lys Val Leu Ser Lys Pro Leu Val Phe Ser Arg Gly Leu Phe Asp 
785                 790                 795                 800 


Ser Asn Pro Thr Phe Ile Lys Gly Val Lys Val Thr Glu Asn Pro Glu 
                805                 810                 815     


Leu Phe Ala Glu Trp Tyr Ser Tyr Gly Tyr Lys Thr Glu His Ser Phe 
            820                 825                 830         


Gln His Phe Tyr Gly Trp Glu Arg Asp Tyr Asn Glu Leu Leu Asp Ser 
        835                 840                 845             


Glu Leu Tyr Lys Asp Asn Asn Phe Ala Lys Asn Ser Ile His Tyr Ser 
    850                 855                 860                 


Arg Glu Ser Gln Leu Asp Leu Ile Lys Leu Lys Gln Asp Leu Lys Ile 
865                 870                 875                 880 


Lys Lys Val Lys Ile Gln Asp Leu Phe Leu Lys Arg Ile Ala Glu Lys 
                885                 890                 895     


Leu Phe Glu Asn Val Phe His Tyr Pro Thr Thr Leu Ser Leu Asp Glu 
            900                 905                 910         


Phe Tyr Met Thr Gln Glu Glu Arg Ala Lys Lys Glu Arg Ile Ala Leu 
        915                 920                 925             


Ala Gln Ser Leu Arg Glu Glu Gly Asp Asn Ser Pro Asn Ile Ile Lys 
    930                 935                 940                 


Asp Asn Phe Ile Trp Ser Lys Thr Thr Ala Phe Arg Ser Lys Gln Ile 
945                 950                 955                 960 


Tyr Glu Pro Thr Ile Lys Leu Lys Asp Leu Gly Lys Phe Asn Arg Phe 
                965                 970                 975     


Leu Leu Asp His Lys Val Leu Met Leu Leu Ser Tyr Asp Pro Asn Lys 
            980                 985                 990         


Ile Trp Asn Lys Glu Gln Leu Glu  Arg Glu Leu Ser Ile  Gly Glu Asn 
        995                 1000                 1005             


Ser Tyr  Glu Val Ile Arg Arg  Glu Arg Leu Phe Lys  Glu Ile Gln 
    1010                 1015                 1020             


Asn Leu  Glu Leu Gln Thr Leu  Ser Asn Trp Ser Trp  Asp Gly Val 
    1025                 1030                 1035             


Asn His  Pro Arg Glu Phe Glu  Ile Glu Asp Gln Lys  Asn Ala Trp 
    1040                 1045                 1050             


His Pro  Asn Phe Lys Met Tyr  Leu Val Asn Gly Ile  Leu Arg Lys 
    1055                 1060                 1065             


Asn Ser  Asn Phe Tyr Lys Glu  Asp Glu Asp Phe Trp  Leu Glu Ser 
    1070                 1075                 1080             


Leu Lys  Glu Asn Asp Phe Lys  Thr Leu Pro Ser Glu  Ile Leu Glu 
    1085                 1090                 1095             


Thr Lys  Ser Glu Met Val Arg  Leu Leu Phe Leu Val  Ile Leu Ile 
    1100                 1105                 1110             


Arg Asn  Gln Phe Ala His Asn  Gln Leu Pro Ala Val  Gln Phe Tyr 
    1115                 1120                 1125             


Asn Phe  Ile Arg Lys Asn Tyr  Pro Glu Ile Gln Asn  Asn Thr Val 
    1130                 1135                 1140             


Ala Glu  Leu Tyr Leu Asp Leu  Val Lys Leu Ala Val  Gln Lys Leu 
    1145                 1150                 1155             


Lys Glu  Asn Ser 
    1160         


<210>  1895
<211>  1145
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1895

Met Glu Thr Leu Thr Ile Pro Glu Val Ile Lys Cys Arg Thr Leu Ser 
1               5                   10                  15      


Asp Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Ile Ala Lys Glu Phe Asp Leu Pro Leu 
        35                  40                  45              


Leu Ala Glu Glu Gly His Leu Lys Asn Ser Phe Leu Cys Lys Lys Glu 
    50                  55                  60                  


His Asn Lys Val Asn Trp Asn His Val Tyr Ser Arg Thr Lys Arg Phe 
65                  70                  75                  80  


Leu Ala Val Leu Lys Val Phe Asp Ala Glu Thr Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Lys Thr Ile Asn Trp Glu Gly Lys Asp Phe Ala Ser Met Ser Asp 
            100                 105                 110         


Ile Leu Lys Ile Val Phe Gly Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Thr Ile Arg Lys Thr Ala Val 
    130                 135                 140                 


Ser Ala Glu Met Ala Leu Phe Leu Thr Thr Asn Phe Arg Arg Ala Ile 
145                 150                 155                 160 


Glu Tyr Thr Lys Glu Arg Phe Lys Gly Val Leu Asn Asp Glu Asp Tyr 
                165                 170                 175     


Gln Leu Val Ala Ser Lys Lys Val Leu Glu Ala Asn Ser Thr Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Arg Phe Ile Gly Ile Ile Thr Gly Leu Lys Gly Thr Gln Asn 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro His Asp Arg Phe Gln Ser Asp Asn Pro Arg Gln Ala Phe Ser 
                245                 250                 255     


Leu Asp Leu Ile Asn Glu Leu Asn Arg Cys Pro Lys Val Leu Tyr Asn 
            260                 265                 270         


Ala Ile Thr Glu Glu Gly Lys Gln Lys Leu Arg Ser Ile Pro Gly Glu 
        275                 280                 285             


Leu Glu Asn Lys Asn Leu His Asp Asn Asn Thr Lys Lys Glu Ala Lys 
    290                 295                 300                 


Ile Glu Ala Glu Ala Tyr Glu Leu Tyr Ile Glu Ser Leu Thr Arg Gln 
305                 310                 315                 320 


Ile Arg Tyr Ser Asn Arg Phe Pro Asp Phe Ala Leu Lys Phe Ile Asp 
                325                 330                 335     


Glu Thr Asp Ile Phe Ser Glu Phe Arg Phe Gln Ile Asp Leu Gly Lys 
            340                 345                 350         


Leu Leu Val Asp Glu Tyr Leu Lys Phe Phe Asn Gly Glu His Val Gln 
        355                 360                 365             


Arg Arg Ile Val Glu Asn Ala Lys Ala Phe Gly Lys Leu Ile Asp Phe 
    370                 375                 380                 


Asn Asp Glu Ala Lys Val Met Thr Arg Ile Gly Asn Gly His Phe Ser 
385                 390                 395                 400 


Lys Arg Phe Glu Gln Phe Ala Pro Phe Tyr Asn Thr Glu Asp Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Arg His His Val Thr Ala Lys Leu Gly Pro Asp Ser 
            420                 425                 430         


Lys Gly Glu Pro Glu Lys Lys Leu Leu Gln Pro Leu Pro Glu Ala Phe 
        435                 440                 445             


Leu Ser Leu His Glu Leu Pro Lys Val Ile Leu Leu Asp Tyr Leu Gln 
    450                 455                 460                 


Lys Gly Glu Pro Glu Lys Leu Ile Asn Asp Phe Ile Leu Ile Asn Asn 
465                 470                 475                 480 


Ser Lys Leu Met Asn Met Ser Phe Ile Glu Ala Val Lys Thr Gln Leu 
                485                 490                 495     


Pro Pro Glu Trp Asp Glu Phe Gln Arg Arg Thr Gly Ser Lys Asn Glu 
            500                 505                 510         


Met Pro Tyr Asn Glu Lys Thr Leu Ala Tyr Leu Leu Gln Arg Lys Gln 
        515                 520                 525             


Ile Leu Asn Lys Ile Leu Ala Glu Phe Gln Leu Asn Asp Lys Gln Ile 
    530                 535                 540                 


Pro Gly Arg Ile Leu Asp Tyr Trp Leu Asn Ile Ala Asp Val Glu Glu 
545                 550                 555                 560 


Glu Arg Ala Val Ser Asp Arg Ile Lys Ser Ile Lys Arg Asp Cys Met 
                565                 570                 575     


Ser Arg Leu Arg Ala Leu Gly Lys Phe Lys Ile Asp Arg Asn Arg Asn 
            580                 585                 590         


Lys Ile Pro Lys Ile Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile 
        595                 600                 605             


Val Asp Met Val Val Ser Glu Gly Lys Lys His Lys Ile Thr Ser Phe 
    610                 615                 620                 


Tyr Tyr Glu Lys Met Gln Asp Cys Leu Ser Leu Phe Ala Asp Pro Leu 
625                 630                 635                 640 


Lys Arg Gln Leu Phe Ile His Ile Ile Thr Asn Glu Leu Arg Leu Asn 
                645                 650                 655     


Asp Ser Gly Gly His Pro Phe Leu Phe Lys Leu Asn Met Arg Gln Ile 
            660                 665                 670         


Asn Cys Thr Ser Asp Phe Tyr Glu Ile Tyr Leu Gln Glu Lys Gly His 
        675                 680                 685             


Lys Met Val Pro Glu Lys Asn Leu Lys Thr Gly Lys Val Val Asn Thr 
    690                 695                 700                 


Asp His Ser Trp Met Ala Leu Thr Phe Tyr Lys Leu Glu Phe Asn Asp 
705                 710                 715                 720 


Lys Val Asp Lys Leu Met Thr Val Val Lys Leu Pro Leu Asn Lys Leu 
                725                 730                 735     


Asn Leu Pro Phe Thr Leu Arg Gln Leu Asn Ala Lys Thr Thr Tyr Thr 
            740                 745                 750         


Leu Glu Gln Trp Leu Lys Asn Leu Thr Leu Gly Lys Lys Pro Asp Asp 
        755                 760                 765             


Gly Lys His Pro Val Asn Leu Pro Thr Asn Leu Phe Asp Glu Lys Leu 
    770                 775                 780                 


Ser Asp Leu Leu Arg Gln Asp Leu Asp Asn Asn Lys Ile Ala Tyr Arg 
785                 790                 795                 800 


Pro Tyr Ala Asn Trp Asn Glu Leu Phe Lys Ile Trp Trp Ile Ser Arg 
                805                 810                 815     


Asn Asp Ser Leu Gln Arg Phe Tyr Asn Ala Glu Arg Glu Tyr His Ile 
            820                 825                 830         


Phe Asn Glu Lys Val Asn Phe Tyr Pro Asn Arg Lys Glu Asn Phe Ala 
        835                 840                 845             


Asp Tyr Tyr Gln His Ala Val Lys Val Ala Phe Gln Lys Lys Arg Asn 
    850                 855                 860                 


Glu Arg Ile Ile Glu Gln Arg Ile Asn Lys Tyr Leu Pro Asp Ile Leu 
865                 870                 875                 880 


Phe Glu Gln Val Glu Lys Thr Phe Lys His Thr Ile Ala Glu Thr Glu 
                885                 890                 895     


Lys Glu Ile Arg Ile Leu Gln Glu Glu Asp Arg Ile Met Leu Leu Met 
            900                 905                 910         


Leu Glu Gly Leu Met Glu Asp Gly Asn Lys Gln Gln Leu Lys Leu Ser 
        915                 920                 925             


Glu Ile Lys Thr Leu Gln Asn Ala Thr Ile Asn Ile Arg Gln Leu Val 
    930                 935                 940                 


Pro Gly Lys Leu Ser Phe Asp Asp Ser Gly Glu Ala Ile Lys Asp Ser 
945                 950                 955                 960 


Thr Asn Pro Glu Ile Val Arg Thr Val Ser Val Ser Ile Lys Arg Ile 
                965                 970                 975     


Glu Tyr Asn Leu Leu Pro Lys Tyr Val Ala Asp Gly Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Pro Asp Glu  Glu Ile Gln Met Glu  Arg Leu Lys 
        995                 1000                 1005             


Thr Glu  Phe Asp Thr Tyr Asn  Lys Val Arg Gln Val  Val Leu Asp 
    1010                 1015                 1020             


Leu Ser  Phe Lys Leu Glu Lys  Met Ile Ile Glu Lys  Gly His Lys 
    1025                 1030                 1035             


Asp Arg  Ile Asn Gln Leu Cys  Thr Gly Ala Thr Gly  Glu Leu Leu 
    1040                 1045                 1050             


Thr Gly  Asn Ile Cys His His  Thr Tyr Leu Thr Trp  Leu Lys Asp 
    1055                 1060                 1065             


Lys Glu  Met Ile Asp Asn Glu  Thr Phe Ile Phe Met  Asn Met Val 
    1070                 1075                 1080             


Gln His  Cys Phe Ser His Asn  Gln Tyr Pro Gln Lys  Lys Thr Met 
    1085                 1090                 1095             


Glu Arg  Ile Ile Asn His Trp  Glu Pro Asp Arg Phe  Ala Leu Thr 
    1100                 1105                 1110             


Ile Ala  Ala Thr Tyr Asn Gln  Lys Ile Ala Gly Ile  Leu Glu Asp 
    1115                 1120                 1125             


Ile Gly  Thr Phe Pro Phe Ile  Arg Ser Arg Lys Thr  Met Pro Asp 
    1130                 1135                 1140             


Val Val  
    1145 


<210>  1896
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1896

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Ala Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Asn Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1897
<211>  1119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1897

Met Glu Asp Asp Lys Lys Thr Thr Asp Ser Ile Arg Tyr Glu Leu Lys 
1               5                   10                  15      


Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val 
            20                  25                  30          


Tyr Ile Thr Val Asn His Ile Asn Lys Ile Leu Glu Glu Gly Glu Ile 
        35                  40                  45              


Asn Arg Asp Gly Tyr Glu Lys Thr Leu Glu Asn Ser Trp Asn Glu Ile 
    50                  55                  60                  


Lys Asp Ile Asn Lys Lys Asp Arg Leu Ser Lys Leu Ile Ile Lys His 
65                  70                  75                  80  


Phe Pro Phe Leu Glu Ala Thr Thr Tyr Arg Gln Asn Pro Thr Asp Thr 
                85                  90                  95      


Thr Lys Gln Lys Glu Glu Lys Gln Ala Glu Ala Gln Ser Leu Glu Asn 
            100                 105                 110         


Leu Lys Glu Ser Phe Phe Val Phe Ile Tyr Lys Leu Arg Asp Leu Arg 
        115                 120                 125             


Asn His Tyr Ser His Tyr Lys His Ser Lys Ser Leu Glu Arg Pro Lys 
    130                 135                 140                 


Phe Glu Glu Asp Leu Gln Lys Lys Met Tyr Asn Ile Phe Asn Ala Ser 
145                 150                 155                 160 


Ile Arg Leu Val Lys Glu Asp Tyr Gln Tyr Asn Lys Asn Ile Asn Pro 
                165                 170                 175     


Lys Lys Asp Phe Lys His Leu Asp Arg Lys Arg Lys Gly Lys Phe Tyr 
            180                 185                 190         


Tyr Ser Phe Ala Asp Asn Glu Gly Asn Ile Thr Glu Ser Gly Leu Leu 
        195                 200                 205             


Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Val Gln 
    210                 215                 220                 


Lys Lys Leu Glu Gly Phe Lys Cys Ser Asn Lys Ser Tyr Gln Lys Met 
225                 230                 235                 240 


Thr Asn Glu Val Phe Cys Arg Ser Arg Met Leu Leu Pro Lys Leu Arg 
                245                 250                 255     


Leu Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu Asn 
            260                 265                 270         


Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Gln Gly Glu 
        275                 280                 285             


Asp Arg Glu Lys Phe Arg Val Pro Leu Asp Pro Ile Asp Glu Asp Tyr 
    290                 295                 300                 


Asp Val Glu Gln Glu Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp 
305                 310                 315                 320 


Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Tyr Asn Glu Ile Phe 
                325                 330                 335     


Thr Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile 
            340                 345                 350         


Tyr Lys Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg His Leu Thr His 
        355                 360                 365             


Lys Leu Tyr Gly Phe Glu Arg Ile Gln Glu Phe Asp Lys Gln Asn Arg 
    370                 375                 380                 


Pro Asp Glu Trp Lys Ala Ile Val Lys Asp Ser Asp Thr Phe Lys Lys 
385                 390                 395                 400 


Lys Glu Glu Lys Glu Glu Lys Pro Tyr Ile Ser Glu Thr Thr Pro His 
                405                 410                 415     


Tyr His Leu Glu Asn Lys Lys Ile Gly Ile Ala Phe Lys Asn His Asn 
            420                 425                 430         


Ile Trp Pro Ser Thr Gln Thr Glu Leu Thr Asn Asn Lys Arg Lys Lys 
        435                 440                 445             


Tyr Asn Leu Gly Thr Ser Ile Lys Ala Glu Ala Phe Leu Ser Val His 
    450                 455                 460                 


Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Lys Thr Glu Asn 
465                 470                 475                 480 


Thr Lys Asn Asp Asn Lys Val Glu Gly Lys Lys Glu Thr Lys Lys Gln 
                485                 490                 495     


Glu Lys His Lys Ile Glu Ala Ile Ile Glu Ser Lys Ile Lys Asp Met 
            500                 505                 510         


Tyr Ala Leu Tyr Asp Ala Phe Ala Asn Gly Glu Ile Asn Ser Glu Lys 
        515                 520                 525             


Glu Leu Glu Glu Tyr Leu Lys Gly Lys Asp Ile Glu Ile Val His Leu 
    530                 535                 540                 


Pro Lys Gln Met Ile Ala Ile Leu Lys Asn Glu His Lys Asp Met Ala 
545                 550                 555                 560 


Glu Lys Ala Glu Ala Lys Gln Glu Lys Met Lys Leu Ala Thr Glu Asn 
                565                 570                 575     


Arg Leu Lys Thr Leu Asp Lys Gln Leu Lys Gly Lys Ile Gln Asn Gly 
            580                 585                 590         


Lys Arg Tyr Asn Ser Ala Pro Lys Ser Gly Glu Ile Ala Ser Trp Leu 
        595                 600                 605             


Val Asn Asp Met Met Arg Phe Gln Pro Val Gln Arg Asp Glu Asn Gly 
    610                 615                 620                 


Glu Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln Leu Leu 
625                 630                 635                 640 


Gln Arg Thr Leu Ala Phe Phe Gly Ser Glu His Glu Arg Leu Ala Pro 
                645                 650                 655     


Tyr Phe Lys Gln Thr Lys Leu Ile Glu Ser Ser Asn Pro His Pro Phe 
            660                 665                 670         


Leu Asn Asp Thr Glu Trp Glu Lys Cys Ser Asn Ile Leu Ser Phe Tyr 
        675                 680                 685             


Arg Ser Tyr Leu Lys Ala Lys Lys Asn Phe Leu Glu Ser Leu Lys Pro 
    690                 695                 700                 


Glu Asp Trp Glu Lys Asn Gln Tyr Phe Leu Met Leu Lys Glu Pro Lys 
705                 710                 715                 720 


Thr Asn Arg Lys Thr Leu Val Gln Gly Trp Lys Asn Gly Phe Asn Leu 
                725                 730                 735     


Pro Arg Gly Ile Phe Thr Lys Pro Ile Arg Lys Trp Phe Met Glu His 
            740                 745                 750         


Trp Lys Asn Ile Lys Val Asp Asp Ser Lys Arg Val Gly Leu Val Ala 
        755                 760                 765             


Lys Val Ile Pro Leu Phe Phe Ser Glu Lys Tyr Lys Asp Ser Val Gln 
    770                 775                 780                 


Pro Phe Tyr Asn Tyr Pro Phe Asn Val Gly Asp Val Asn Lys Pro Lys 
785                 790                 795                 800 


Glu Glu Asp Phe Leu His Arg Glu Glu Arg Ile Glu Leu Trp Asp Lys 
                805                 810                 815     


Lys Lys Asp Lys Phe Lys Gly Tyr Lys Ala Lys Lys Lys Phe Lys Glu 
            820                 825                 830         


Met Thr Asp Lys Glu Lys Glu Glu His Arg Ser Tyr Leu Glu Phe Gln 
        835                 840                 845             


Ser Trp Asn Lys Phe Glu Arg Glu Leu Arg Leu Val Arg Asn Gln Asp 
    850                 855                 860                 


Ile Val Ser Trp Leu Leu Cys Thr Glu Leu Ile Asp Lys Leu Lys Ile 
865                 870                 875                 880 


Asp Glu Leu Asn Ile Lys Glu Leu Lys Lys Leu Arg Leu Lys Asp Ile 
                885                 890                 895     


Asn Thr Asp Thr Ala Lys Lys Glu Lys Asn Asn Ile Leu Asn Arg Val 
            900                 905                 910         


Met Pro Met Glu Leu Pro Val Thr Val Tyr Glu Val Asn Gln Gly Gly 
        915                 920                 925             


Tyr Ile Ile Lys Asn Lys Pro Leu His Thr Ile Tyr Ile Lys Glu Ala 
    930                 935                 940                 


Glu Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys Asp 
945                 950                 955                 960 


Arg Arg Leu Asn Gly Leu Phe Ser Phe Val Lys Thr Pro Ser Glu Ala 
                965                 970                 975     


Glu Ser Lys Ser Asn Pro Ile Ser Lys Ser Arg Val Glu Ser Glu Leu 
            980                 985                 990         


Gly Lys Tyr Gln Asn Ala Arg Leu  Asp Ile Ile Glu Asp  Met Leu Ala 
        995                 1000                 1005             


Leu Glu  Lys Lys Leu Ile Asp  Lys Tyr Asn Ser Leu  Asp Thr Asp 
    1010                 1015                 1020             


Asn Phe  His Asn Met Leu Thr  Gly Trp Leu Glu Leu  Lys Gly Glu 
    1025                 1030                 1035             


Ala Asn  Lys Ala Arg Phe Gln  Asn Glu Val Asp Leu  Leu Ile Ala 
    1040                 1045                 1050             


Val Arg  Asn Ala Phe Ser His  Asn Gln Tyr Pro Met  Tyr Asn Glu 
    1055                 1060                 1065             


Asn Leu  Phe Gly Asn Ile Glu  Arg Phe Ser Leu Ser  Ser Ser Asn 
    1070                 1075                 1080             


Ile Ile  Glu Ser Lys Gly Leu  Asp Ile Ala Ala Lys  Leu Lys Glu 
    1085                 1090                 1095             


Glu Val  Ser Arg Ala Ala Lys  Lys Ile Gln Asn Glu  Glu Asp Asp 
    1100                 1105                 1110             


Lys Lys  Glu Lys Glu Thr 
    1115                 


<210>  1898
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1898

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Ala Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Asn Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1899
<211>  1206
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1899

Met Ser Ser Lys Asn Glu Ser Tyr Asn Lys Gln Lys Thr Phe Asn His 
1               5                   10                  15      


Tyr Lys Gln Glu Asp Lys Tyr Phe Phe Gly Gly Phe Leu Asn Asn Ala 
            20                  25                  30          


Glu Glu Asn Ile Ile Thr Ser Phe Lys Glu Ile Ala Lys Arg Leu Asn 
        35                  40                  45              


Ser Lys Glu Lys Asn Lys Pro Ile Glu Ile Leu Gln Glu Ile Leu Ser 
    50                  55                  60                  


Glu Asn Ile Ile Asp Thr Glu Trp Asp Arg Asn Ile Lys Val Ile Ala 
65                  70                  75                  80  


Glu Tyr Phe Pro Phe Val Lys Leu Leu Glu Thr Ile Thr Glu Arg Gln 
                85                  90                  95      


Tyr Lys Lys His Lys Asn Lys Leu Phe Phe Lys Glu Arg Asn Pro Arg 
            100                 105                 110         


Gln Asn Phe Lys Asn Leu Phe Leu Tyr Asn Cys Ile Ile Leu Phe Asn 
        115                 120                 125             


Ser Pro Leu Gln Leu Arg Asp Phe Tyr Thr His Phe Tyr His Arg Asn 
    130                 135                 140                 


Phe Ile Thr Ile Ser Phe Pro Asp Phe Arg Arg Thr Thr Ile Asp Asn 
145                 150                 155                 160 


Asn Ser Ile Thr Asp Tyr Ile Lys Asn Glu Ala Ile Gln His Ser Ala 
                165                 170                 175     


Gln Ser Asp Gly Val Asn Phe Ile Ala His Ser Ile Phe Glu Leu Leu 
            180                 185                 190         


Asp Glu Leu Lys Leu Glu Thr Val Ser Gln Val Asn Asn Gln Arg Ile 
        195                 200                 205             


Lys Pro Asn Glu Lys His Ser Phe Leu Lys Lys Asn Tyr Gln Asn Asp 
    210                 215                 220                 


Phe Thr Asp Leu Thr Glu Glu Glu Ile Ser Lys Lys Phe Lys Lys Val 
225                 230                 235                 240 


Phe Asn Gln Phe Trp Thr Phe Asn Asp Tyr Lys Gly Arg Met Val Leu 
                245                 250                 255     


Lys Asp Phe His Lys Ser His Phe Val Glu Lys Val Glu Glu Gly Ser 
            260                 265                 270         


Met Glu Gln Lys Pro Lys Lys Asp Phe Phe His Gln Lys Ile Ser Arg 
        275                 280                 285             


Ser Gly Phe Leu Phe Leu Leu Ser Leu Phe Val Asp Arg Lys Asn Ala 
    290                 295                 300                 


Glu Phe Ile Leu Asp Asn Ser Thr Tyr Phe Lys Ala Ser Phe Asp Leu 
305                 310                 315                 320 


Gln Lys Leu Ala Thr Arg Trp Val Tyr Thr Tyr Asn Cys Tyr Arg Gly 
                325                 330                 335     


Leu Lys Asn Thr Val Asn Thr Thr Phe Pro Lys Glu Thr Leu Leu Ser 
            340                 345                 350         


Lys Met Val Asp Tyr Leu Ser Lys Val Pro Asp Glu Val Tyr Gln Leu 
        355                 360                 365             


Leu Ser Thr Glu Gln Gln Glu Met Phe Leu Glu Asp Met Asn Glu Tyr 
    370                 375                 380                 


Met Arg Asp Asn Glu Glu Asn Asn Asp Ser Ser Glu Ala Ser Lys Val 
385                 390                 395                 400 


Val His Pro Val Ile Arg Lys Arg Tyr Ser Asn Glu Phe Asn Tyr Leu 
                405                 410                 415     


Ala Leu Ser Phe Ile Asp Gln Tyr Ile Gln Leu Pro Asn Leu Arg Phe 
            420                 425                 430         


Ala Ile Asn Leu Gly Thr Tyr Val His Asn Lys Lys Glu Lys Ile Val 
        435                 440                 445             


Gly Lys Gly Lys Thr Ser Ser Thr Ser Asn Arg Val Ile Lys Glu Asp 
    450                 455                 460                 


Ile Arg Ile Tyr Ala Arg Leu His Glu Ala Ile Asp Phe Lys Asn Asn 
465                 470                 475                 480 


Phe Phe Leu Lys Glu Asn Phe Ser Glu Asp Asn Lys Asp Gly Tyr Trp 
                485                 490                 495     


Glu Glu Phe Pro Asn Pro His Tyr Ala Ile Lys Asp Asn Asn Ile Gly 
            500                 505                 510         


Ile Tyr Phe Ile Asn Lys Asp Val Ile Gln Thr Asn Leu Glu Glu Arg 
        515                 520                 525             


Ser Asn Gly Lys Lys Lys Lys Ala Ser Ile Ile Glu Ile Leu Thr Glu 
    530                 535                 540                 


Thr Glu Ser Asp Thr Ile Lys Tyr Gly Lys Pro His Ala Leu Leu Ser 
545                 550                 555                 560 


Cys Tyr Glu Leu Ile Pro Leu Leu Phe Asp Tyr Phe Gln Lys Val Lys 
                565                 570                 575     


Asn Ser Arg Glu Lys Lys Leu Asn Glu Lys Glu Leu Glu Ala Ile Pro 
            580                 585                 590         


Ile Gln Ile Glu Asn Lys Ile Leu Ser Ala Ile Asn Ser Phe Thr Lys 
        595                 600                 605             


Ser Phe Glu Asn Tyr Ser Glu Gly Lys Asn Ile Leu Lys Ser Tyr Pro 
    610                 615                 620                 


Lys Lys Leu Ser Lys Thr Ser Asn Gln Thr Ser Phe Leu Glu Val Gln 
625                 630                 635                 640 


Asp Glu Asn Gly Asn Pro Ala Lys Lys Ile Phe Gln Asp Ile Asp Lys 
                645                 650                 655     


Glu Ile Gln Lys Ser Gln Asp Lys Leu Asp Ile Leu Lys Lys Asn Glu 
            660                 665                 670         


Asn Glu Phe Gln Asn Asn Glu Arg Lys Ala Thr Phe Ser Lys Lys Glu 
        675                 680                 685             


Ile Gly Glu Glu Ala Thr Trp Leu Ala Asn Asp Ile Leu Arg Phe Met 
    690                 695                 700                 


Pro Ser Ser Phe Lys Lys Asp Trp Lys Gly Tyr Glu His Ser His Leu 
705                 710                 715                 720 


Gln Tyr Leu Leu Ala Phe Tyr Glu Val Arg Lys Thr Glu Ile Phe Gln 
                725                 730                 735     


Leu Leu Asn Gln Lys Trp Pro Leu Tyr Glu Asp Asn Phe Met Gly Glu 
            740                 745                 750         


Ser Leu Arg Thr Phe Leu Asp Asn Arg Lys Thr Phe Glu Ser Phe Tyr 
        755                 760                 765             


Lys Gly Tyr Leu Asp Lys Arg Lys Glu Ile Phe Glu Asn Leu Lys Asn 
    770                 775                 780                 


Asn Leu Ser Leu Asn Asn Asp Asn Leu Phe Arg Val Phe Asp Glu Arg 
785                 790                 795                 800 


Lys Tyr Thr Thr Lys Cys Leu Glu Cys Tyr Lys Lys Leu Ile Leu Glu 
                805                 810                 815     


Gln Pro Val Ser Phe Ser Arg Gly Ile Phe Glu Asp Lys Lys Ala Ala 
            820                 825                 830         


Ile Lys Asn Glu Trp Ser Leu Ile Pro Lys Asp Pro Ala Thr Glu Tyr 
        835                 840                 845             


Gln Ser Phe Tyr Asn Leu Ile Asn Ile Tyr Thr Asn Glu Ala Ile Asp 
    850                 855                 860                 


Lys Glu Glu Lys Lys Glu Lys Tyr Lys Asn Leu Arg Ala Ile Asn Lys 
865                 870                 875                 880 


Val Lys Ile Gln Asp Tyr Tyr Leu Lys Leu Met Val Asp Thr Leu Tyr 
                885                 890                 895     


Gln Asp Leu Phe Asn Leu Pro Leu Asp Lys Ser Leu Ser Asp Phe Tyr 
            900                 905                 910         


Val Ser Lys Ala Glu Arg Glu Lys Ile Lys Ala Asp Ala Lys Ala Tyr 
        915                 920                 925             


Gln Lys Arg Asn Asp Ser Ser Leu Trp Asn Lys Val Ile His Leu Ser 
    930                 935                 940                 


Leu Gln Asn Asn Arg Ile Thr Ala Asn Pro Lys Leu Lys Asp Ile Gly 
945                 950                 955                 960 


Lys Tyr Lys Arg Ala Leu Gln Asp Glu Lys Ile Ala Thr Leu Leu Thr 
                965                 970                 975     


Tyr Asp Asp Arg Thr Trp Ser Tyr Ala Leu Gln Lys Pro Glu Lys Glu 
            980                 985                 990         


Asn Glu Asn Asp Tyr Lys Glu Leu  His Tyr Thr Ala Leu  Asn Met Glu 
        995                 1000                 1005             


Leu Gln  Glu Tyr Glu Lys Val  Arg Ser Lys Lys Leu  Leu Lys Gln 
    1010                 1015                 1020             


Val Gln  Gln Leu Glu Lys Gln  Ile Leu Asp Lys Phe  Tyr Asp Phe 
    1025                 1030                 1035             


Ser Asn  Asn Ala Thr His Pro  Glu Asp Leu Glu Ile  Glu Asp Lys 
    1040                 1045                 1050             


Lys Gly  Lys Arg His Pro Asn  Phe Lys Leu Tyr Ile  Thr Lys Ala 
    1055                 1060                 1065             


Leu Leu  Lys Asn Glu Ser Glu  Ile Ile Asn Leu Glu  Asn Ile Asp 
    1070                 1075                 1080             


Ile Glu  Ile Leu Ile Lys Tyr  Tyr Asp Tyr Asn Thr  Glu Lys Leu 
    1085                 1090                 1095             


Lys Glu  Lys Ile Lys Asn Met  Asp Glu Asp Glu Lys  Ala Lys Ile 
    1100                 1105                 1110             


Val Asn  Thr Lys Glu Asn Tyr  Asn Lys Ile Thr Asn  Val Leu Ile 
    1115                 1120                 1125             


Lys Lys  Ala Leu Val Leu Ile  Ile Ile Arg Asn Lys  Met Ala His 
    1130                 1135                 1140             


Asn Gln  Tyr Pro Pro Lys Phe  Ile Tyr Asp Leu Ala  Thr Ser Phe 
    1145                 1150                 1155             


Gln Asn  Asp Lys Arg Asn Lys  Asp Trp Glu Lys Phe  Val His Gln 
    1160                 1165                 1170             


Lys Glu  Ser Glu Tyr Phe Ala  Thr Tyr Phe Asn Arg  Val Phe Glu 
    1175                 1180                 1185             


Thr Ile  Thr Thr Glu Leu Trp  Glu Asn Lys Lys Glu  Lys Ala Lys 
    1190                 1195                 1200             


Glu Ile  Val 
    1205     


<210>  1900
<211>  1367
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1900

Met Gly Lys Asn Lys Lys Lys Tyr Gln Ala Lys Gly Gln Asp Gln Glu 
1               5                   10                  15      


Ser Lys Leu Pro Lys Lys Asn Val Lys Lys Pro Met Ala Leu Val Val 
            20                  25                  30          


Asn Glu Asn Asn Lys Tyr Val Leu Gly Cys Tyr Phe Ser Leu Gly Leu 
        35                  40                  45              


Asn Asn Phe Tyr Lys Thr Ile Leu Leu Val Phe Ala Lys Thr Gly Ile 
    50                  55                  60                  


Lys Val Met Ser Asp Asn Gly Asn Ile Leu Tyr Gly Glu Glu Lys Ile 
65                  70                  75                  80  


Gly Gln Val Leu Cys Thr Leu Tyr Lys Cys Thr Leu Ser Ser Ser Pro 
                85                  90                  95      


Lys Phe Glu Pro Phe Glu Gln Ala Trp Ser Lys Asn Phe Lys Leu Asn 
            100                 105                 110         


Ala Asn Gln Gln Ala Thr Leu Arg Arg Leu Leu Phe His His Phe Pro 
        115                 120                 125             


Val Leu Gly Pro Ile Met Ala Asp Glu Glu Ala Tyr Lys Val Ile Lys 
    130                 135                 140                 


Thr Lys Lys Ser Asn Val Thr Asp Thr Tyr Ser Met Thr Leu Gly Val 
145                 150                 155                 160 


Thr Leu Pro Glu Cys Leu Lys Val Ile Cys Asn Ile Ala Gln Gly Leu 
                165                 170                 175     


Val Asp Cys Arg Asn Thr Asp Val His Tyr Ala Pro Tyr Asn Ser Ile 
            180                 185                 190         


Asp Asp Leu Ser Lys Gln Tyr Leu Val Gln Glu Asp Ile Val Arg Tyr 
        195                 200                 205             


Leu Asn Lys Ala Leu Val Ala Ser Arg Arg Ile Asp Lys Lys Arg Asn 
    210                 215                 220                 


Ser Ile Glu Thr Glu Lys Met Glu Phe Leu Thr Gly Tyr Ala Asn Val 
225                 230                 235                 240 


Asp Thr Leu Asn Arg Tyr Leu Asn Lys Trp His Phe Tyr Pro Lys Tyr 
                245                 250                 255     


Asp Gln Leu Thr Lys Arg Asp Ser Asp Gly Asn Ile Leu Tyr Val Gln 
            260                 265                 270         


Glu Thr Asp Lys Arg Gly Asn Pro Leu Phe Asp Arg Gln Gly Asn Pro 
        275                 280                 285             


Val Tyr Lys Gln Glu Arg Asp Arg Tyr Gly Ile Ile Val Lys Asn Ala 
    290                 295                 300                 


Asp Gly Thr Pro Lys Tyr Glu Glu Gln Lys Ile Met Val Glu Arg Asn 
305                 310                 315                 320 


Asp Phe Phe Tyr Arg Ile Gly Gly Glu Thr Thr Ile Glu Lys Met Gly 
                325                 330                 335     


Lys Ser Tyr Ser Thr Leu Thr Gly Phe Gly Leu Ala Tyr Phe Cys Thr 
            340                 345                 350         


Leu Phe Leu Ser Lys Pro Gln Ala Lys Gln Met Leu Thr Asp Ile Lys 
        355                 360                 365             


Leu Phe Glu Arg Ser Pro Tyr Pro Gln Glu Leu Asn Asp Ile Ile Arg 
    370                 375                 380                 


Asp Met Leu Ser Ile Tyr Arg Leu Arg Ser Pro Lys Gly Arg Lys Leu 
385                 390                 395                 400 


Glu Gly Asn Asp Asn Lys Val Thr Leu Ala Leu Asp Ile Leu Asn Glu 
                405                 410                 415     


Leu Arg Lys Cys Pro Lys Glu Leu Tyr Asp Val Leu Ser Pro Glu Gly 
            420                 425                 430         


Gln Ala Phe Phe Glu Asp Glu Val Lys Arg Pro Asn Glu Arg Thr Pro 
        435                 440                 445             


Glu Val Val Lys Arg Phe Arg Ser Met Asp Arg Phe Pro Phe Leu Cys 
    450                 455                 460                 


Leu Lys Tyr Ile Asp Glu Thr Gly Val Phe Asp Asn Ile Arg Phe Gln 
465                 470                 475                 480 


Val Gln Leu Gly Lys Leu Arg Phe Lys Phe Tyr Pro Lys Thr Cys Ile 
                485                 490                 495     


Asn Gly Glu Glu Glu Ile Arg Ser Leu Gln Lys Glu Ile Asn Gly Tyr 
            500                 505                 510         


Gly Lys Leu Gln Glu Ile Glu Leu Lys Arg Lys Ser Glu Tyr Gly Asp 
        515                 520                 525             


Leu Leu Gln Ala Ser Ala Glu Lys Ser Val Lys Met Glu His Glu Asp 
    530                 535                 540                 


Ile Tyr Leu Asp Leu Arg Gln Phe Glu Lys Asp Arg Ala Asp Ser Arg 
545                 550                 555                 560 


Pro Tyr Ile Thr Asp Asn Lys Ala Phe Tyr Asn Ile His Asn Asn Arg 
                565                 570                 575     


Ile Gly Leu Tyr Trp Asn Glu Leu Glu Tyr Val Asp Lys Gln Thr Asn 
            580                 585                 590         


Lys Lys Val Val Lys Leu Gln Ile Gly Asp Tyr Ile Pro Asp Leu Ser 
        595                 600                 605             


Cys Val Asn Asn Gly Lys Ala Pro Val Val Met Pro Ala Pro Met Ala 
    610                 615                 620                 


Met Leu Ser Val Tyr Glu Leu Pro Ala Leu Ile Phe Phe Gln Tyr Leu 
625                 630                 635                 640 


Cys Asn Gln Gln Lys Gly Met Glu Ser Pro Thr Thr Glu Glu Ile Ile 
                645                 650                 655     


Thr Gln Lys Tyr Asn Ser Leu Lys Arg Phe Phe Gln Asp Val Ser Thr 
            660                 665                 670         


Gly Thr Leu Gln Pro Phe Glu Lys Lys Lys Leu Leu Ala Glu Ala Leu 
        675                 680                 685             


Ser Ser Gln Tyr Glu Leu Glu Val Arg Glu Ile Pro Asp Lys Leu Gln 
    690                 695                 700                 


Asp Tyr Leu Thr Lys Lys Asn Ile Asn Ile Asp Ser Lys Lys Gln Lys 
705                 710                 715                 720 


Leu Thr Gln Asp Ile Leu Val Thr Arg Leu Arg Lys Ala Ile Arg Arg 
                725                 730                 735     


Arg Asp Gly Tyr Lys Asp Asp Arg Lys Lys Ile Gly Asp Lys Glu Asn 
            740                 745                 750         


Arg Tyr Gly Lys Asp Ser Tyr Val Asp Val Arg His Gly Ser Leu Ala 
        755                 760                 765             


Arg Tyr Leu Ser Glu Ser Phe Ile Glu Trp Gln Pro Thr Met Glu Lys 
    770                 775                 780                 


Gly Arg Asp Lys Leu Thr Gly Met Asn Phe Ser Lys Leu Gln Ser Glu 
785                 790                 795                 800 


Leu Ala Ile Phe Asp Ser Val Glu Lys Tyr Pro Ser Leu Lys Asp Leu 
                805                 810                 815     


Leu Gly Lys Ala Asn Leu Leu Ser Gly Asn Ile Ala His Pro Phe Leu 
            820                 825                 830         


Asn Asn Ile Met Gly Lys Thr Ile His Asn Ile Glu Glu Leu Tyr Leu 
        835                 840                 845             


Leu Tyr Leu Asn Glu Glu Ile Lys Tyr Leu Arg Lys Leu Phe Ala Ile 
    850                 855                 860                 


Asp Ile Lys Val Lys Asp Gly Asp Ile Lys Phe Asp Lys Leu Lys Leu 
865                 870                 875                 880 


Asn Ala Pro Asp Tyr Thr Lys Leu Pro Phe Ile Arg Gly Glu Lys Lys 
                885                 890                 895     


Trp Glu Gln Arg Asn Asp Glu Tyr Tyr Lys Gln Leu Ala Lys Arg Tyr 
            900                 905                 910         


Leu Glu Ile Glu Gly Lys Arg Ala Pro Ile Asn Leu Pro Asn Gly Ile 
        915                 920                 925             


Phe Thr Asp Tyr Ile Ile Lys Ile Leu Arg Asn Asp Tyr Ala Ser Asn 
    930                 935                 940                 


Ala Gln Leu Gln Glu Cys Leu Lys Asp Glu Gln Leu Val Asn Asn Val 
945                 950                 955                 960 


Ser Tyr Leu Ile Arg Ala Phe Phe Gln Tyr Gln Leu Lys Asp Asn Ser 
                965                 970                 975     


Gln Pro Phe Tyr Phe Ser Ser Lys Lys Ile Ser Glu Asp Glu Glu Val 
            980                 985                 990         


Pro Thr Arg Phe Val His Phe Tyr  Asp Leu Phe Asn Ile  Leu Asn Asn 
        995                 1000                 1005             


Glu Lys  Lys Arg Asn Ala Tyr  Val Lys Val Pro Met  Thr Val Ser 
    1010                 1015                 1020             


Gln Ile  Ile Lys Arg Phe Thr  Asp Phe Ala Leu Asp  Glu Asp Asn 
    1025                 1030                 1035             


Asp Arg  Ile Glu Leu Ile Gly  Ser Asn Arg Lys Pro  Met Arg Asp 
    1040                 1045                 1050             


Gly Glu  Gly Asn Ile Arg Tyr  Lys Lys Lys Ile Gln  Thr Glu Ile 
    1055                 1060                 1065             


Glu Glu  Arg Val Ala Ala Met  Thr Tyr Lys Glu Lys  Gly Asn His 
    1070                 1075                 1080             


Lys Ser  Leu Asp Asp Ala Arg  Glu Ala Met Leu Arg  Lys Leu Lys 
    1085                 1090                 1095             


His Ala  Val Asn Asp Val Lys  Asp Asn Glu Arg Ala  Ile Arg Arg 
    1100                 1105                 1110             


Tyr Lys  Ala Gln Asp Met Ile  Leu Phe Leu Met Val  Asp Lys Leu 
    1115                 1120                 1125             


Ile Ser  Asp Ser Val Ala Thr  Gly Lys Val Asp Asn  Phe Gln Asn 
    1130                 1135                 1140             


Phe Lys  Leu Glu Asn Val Cys  Arg Asp Asp Phe Leu  Ser Gln Thr 
    1145                 1150                 1155             


Val Asn  Phe Glu Phe Pro Phe  Ala Val Gly Asn Asp  Thr Val Ser 
    1160                 1165                 1170             


Ile Cys  Gln Glu Ala Met Ser  Leu Lys Asn Tyr Gly  Glu Phe Tyr 
    1175                 1180                 1185             


Arg Leu  Leu Ser Asp Asp Arg  Leu Pro Ser Leu Leu  Asn Arg Leu 
    1190                 1195                 1200             


Val Thr  Ala Lys Lys Lys Glu  Gly Glu Asn Val Thr  Val Asp Tyr 
    1205                 1210                 1215             


Asn Ser  Leu Met Gly Glu Leu  Ala Ser Tyr Asp Ile  His Arg Ser 
    1220                 1225                 1230             


Arg Ile  Phe Ser Ala Val His  Lys Leu Glu Lys Tyr  Val Val Ser 
    1235                 1240                 1245             


Leu Lys  Glu Phe Glu Ser Phe  Leu Asn Asn Pro Asp  Asp Lys Arg 
    1250                 1255                 1260             


Phe Tyr  Ile Asn Asp Asp Lys  Lys Arg Asp Pro Lys  Arg Asn Asn 
    1265                 1270                 1275             


Phe Arg  Glu Leu Leu Tyr Leu  Leu Glu Glu Ser Asp  Glu Asp Ile 
    1280                 1285                 1290             


Leu Asn  Ser Asp Ala Lys Glu  Leu Leu Ile Ser Ile  Arg Asn Ala 
    1295                 1300                 1305             


Phe Ser  His Asn His Tyr Gly  Ile Asp Phe Glu Lys  Ile Ala Leu 
    1310                 1315                 1320             


Pro Glu  Gln Met Ala Lys Ser  Thr Leu Met His Glu  Val Thr Asp 
    1325                 1330                 1335             


Gly Asp  Ala Thr Glu Asn Leu  Thr Thr Ile Ala Thr  Leu Ile Ala 
    1340                 1345                 1350             


Lys Arg  Met Thr Gln Leu Gln  Lys Leu Val Cys Glu  Gly Leu 
    1355                 1360                 1365         


<210>  1901
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1901

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Ala Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Asn Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1902
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1902

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Ala Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Asn Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1903
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1903

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Ile Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1904
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1904

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Ile Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1905
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1905

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Ala Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Asn Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1906
<211>  1179
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1906

Met Ser Ser Lys Asn Glu Ser Tyr Asn Lys Gln Lys Thr Phe Asn His 
1               5                   10                  15      


Tyr Lys Gln Glu Asp Lys Tyr Phe Phe Gly Gly Phe Leu Asn Asn Ala 
            20                  25                  30          


Asp Asp Asn Leu Arg Gln Val Gly Lys Glu Phe Lys Thr Arg Ile Asn 
        35                  40                  45              


Phe Asn His Asn Asn Asn Glu Leu Ala Ser Val Phe Lys Asp Tyr Phe 
    50                  55                  60                  


Asn Lys Glu Lys Ser Val Ala Lys Arg Glu His Ala Leu Asn Leu Leu 
65                  70                  75                  80  


Ser Asn Tyr Phe Pro Val Leu Glu Arg Ile Gln Lys His Thr Asn His 
                85                  90                  95      


Asn Phe Glu Gln Thr Arg Glu Ile Phe Glu Leu Leu Leu Asp Thr Ile 
            100                 105                 110         


Lys Lys Leu Arg Asp Tyr Tyr Thr His His Tyr His Lys Pro Ile Thr 
        115                 120                 125             


Ile Asn Pro Lys Ile Tyr Asp Phe Leu Asp Asp Thr Leu Leu Asp Val 
    130                 135                 140                 


Leu Ile Thr Ile Lys Lys Lys Lys Val Lys Asn Asp Thr Ser Arg Glu 
145                 150                 155                 160 


Leu Leu Lys Glu Lys Leu Arg Pro Glu Leu Thr Gln Leu Lys Asn Gln 
                165                 170                 175     


Lys Arg Glu Glu Leu Ile Lys Lys Gly Lys Lys Leu Leu Glu Glu Asn 
            180                 185                 190         


Leu Glu Asn Ala Val Phe Asn His Cys Leu Ile Pro Phe Leu Glu Glu 
        195                 200                 205             


Asn Lys Thr Asp Asp Lys Gln Asn Lys Thr Val Ser Leu Arg Lys Tyr 
    210                 215                 220                 


Arg Lys Ser Lys Pro Asn Glu Glu Thr Ser Ile Thr Leu Thr Gln Ser 
225                 230                 235                 240 


Gly Leu Val Phe Leu Met Ser Phe Phe Leu His Arg Lys Glu Phe Gln 
                245                 250                 255     


Val Phe Thr Ser Gly Leu Glu Arg Phe Lys Ala Lys Val Asn Thr Ile 
            260                 265                 270         


Lys Glu Glu Glu Ile Ser Leu Asn Lys Asn Asn Ile Val Tyr Met Ile 
        275                 280                 285             


Thr His Trp Ser Tyr Ser Tyr Tyr Asn Phe Lys Gly Leu Lys His Arg 
    290                 295                 300                 


Ile Lys Thr Asp Gln Gly Val Ser Thr Leu Glu Gln Asn Asn Thr Thr 
305                 310                 315                 320 


His Ser Leu Thr Asn Thr Asn Thr Lys Glu Ala Leu Leu Thr Gln Ile 
                325                 330                 335     


Val Asp Tyr Leu Ser Lys Val Pro Asn Glu Ile Tyr Glu Thr Leu Ser 
            340                 345                 350         


Glu Lys Gln Gln Lys Glu Phe Glu Glu Asp Ile Asn Glu Tyr Met Arg 
        355                 360                 365             


Glu Asn Pro Glu Asn Glu Asp Ser Thr Phe Ser Ser Ile Val Ser His 
    370                 375                 380                 


Lys Val Ile Arg Lys Arg Tyr Glu Asn Lys Phe Asn Tyr Phe Ala Met 
385                 390                 395                 400 


Arg Phe Leu Asp Glu Tyr Ala Glu Leu Pro Thr Leu Arg Phe Met Val 
                405                 410                 415     


Asn Phe Gly Asp Tyr Ile Lys Asp Arg Gln Lys Lys Ile Leu Glu Ser 
            420                 425                 430         


Ile Gln Phe Asp Ser Glu Arg Ile Ile Lys Lys Glu Ile His Leu Phe 
        435                 440                 445             


Glu Lys Leu Ser Leu Val Thr Glu Tyr Lys Lys Asn Val Tyr Leu Lys 
    450                 455                 460                 


Glu Thr Ser Asn Ile Asp Leu Ser Arg Phe Pro Leu Phe Pro Asn Pro 
465                 470                 475                 480 


Ser Tyr Val Met Ala Asn Asn Asn Ile Pro Phe Tyr Ile Asp Ser Arg 
                485                 490                 495     


Ser Asn Asn Leu Asp Glu Tyr Leu Asn Gln Lys Lys Lys Thr Gln Ser 
            500                 505                 510         


Gln Asn Arg Lys Arg Asn Leu Thr Phe Glu Lys Tyr Asn Lys Glu Gln 
        515                 520                 525             


Ser Lys Asp Ala Ile Ile Ala Met Leu Gln Lys Glu Ile Gly Val Lys 
    530                 535                 540                 


Asp Leu Gln Gln Arg Ser Thr Ile Gly Leu Leu Ser Cys Asn Glu Leu 
545                 550                 555                 560 


Pro Ser Met Leu Tyr Glu Val Ile Val Lys Asp Ile Lys Gly Ala Glu 
                565                 570                 575     


Leu Glu Asn Lys Ile Ala Gln Lys Ile Arg Glu Gln Tyr Gln Ser Ile 
            580                 585                 590         


Arg Asp Phe Thr Leu Asp Ser Pro Gln Lys Asp Asn Ile Pro Thr Thr 
        595                 600                 605             


Leu Ile Lys Thr Ile Asn Thr Asp Ser Ser Val Thr Phe Glu Asn Gln 
    610                 615                 620                 


Pro Ile Asp Ile Pro Arg Leu Lys Asn Ala Ile Gln Lys Glu Leu Ala 
625                 630                 635                 640 


Leu Thr Gln Glu Lys Leu Leu Asn Val Lys Glu His Glu Ile Glu Val 
                645                 650                 655     


Asp Asn Tyr Asn Arg Asn Lys Asn Thr Tyr Lys Phe Lys Asn Gln Pro 
            660                 665                 670         


Lys Asn Lys Val Asp Asp Lys Lys Leu Gln Arg Lys Tyr Val Phe Tyr 
        675                 680                 685             


Arg Asn Glu Ile Arg Gln Glu Ala Asn Trp Leu Ala Ser Asp Leu Ile 
    690                 695                 700                 


His Phe Met Lys Asn Lys Ser Leu Trp Lys Gly Tyr Met His Asn Glu 
705                 710                 715                 720 


Leu Gln Ser Phe Leu Ala Phe Phe Glu Asp Lys Lys Asn Asp Cys Ile 
                725                 730                 735     


Ala Leu Leu Glu Thr Val Phe Asn Leu Lys Glu Asp Cys Ile Leu Thr 
            740                 745                 750         


Lys Gly Leu Lys Asn Leu Phe Leu Lys His Gly Asn Phe Ile Asp Phe 
        755                 760                 765             


Tyr Lys Glu Tyr Leu Lys Leu Lys Glu Asp Phe Leu Ser Thr Glu Ser 
    770                 775                 780                 


Thr Phe Leu Glu Asn Gly Phe Ile Gly Leu Pro Pro Lys Ile Leu Lys 
785                 790                 795                 800 


Lys Glu Leu Ser Lys Arg Leu Asn Tyr Ile Phe Ile Val Phe Gln Lys 
                805                 810                 815     


Arg Gln Phe Ile Ile Lys Glu Leu Glu Glu Lys Lys Asn Asn Leu Tyr 
            820                 825                 830         


Ala Asp Ala Ile Asn Leu Ser Arg Gly Ile Phe Asp Glu Lys Pro Thr 
        835                 840                 845             


Met Ile Pro Phe Lys Lys Pro Asn Pro Asp Glu Phe Ala Ser Trp Phe 
    850                 855                 860                 


Val Ala Ser Tyr Gln Tyr Asn Asn Tyr Gln Ser Phe Tyr Glu Leu Thr 
865                 870                 875                 880 


Pro Asp Ile Val Glu Arg Asp Lys Lys Lys Lys Tyr Lys Asn Leu Arg 
                885                 890                 895     


Ala Ile Asn Lys Val Lys Ile Gln Asp Tyr Tyr Leu Lys Leu Met Val 
            900                 905                 910         


Asp Thr Leu Tyr Gln Asp Leu Phe Asn Gln Pro Leu Asp Lys Ser Leu 
        915                 920                 925             


Ser Asp Phe Tyr Val Ser Lys Ala Glu Arg Glu Lys Ile Lys Ala Asp 
    930                 935                 940                 


Ala Lys Ala Tyr Gln Lys Arg Asn Asp Ser Ser Leu Trp Asn Lys Val 
945                 950                 955                 960 


Ile His Leu Ser Leu Gln Asn Asn Arg Ile Thr Ala Asn Pro Lys Leu 
                965                 970                 975     


Lys Asp Ile Gly Lys Tyr Lys Arg Ala Leu Gln Asp Glu Lys Ile Ala 
            980                 985                 990         


Thr Leu Leu Thr Tyr Asp Ala Arg  Thr Trp Thr Tyr Ala  Leu Gln Lys 
        995                 1000                 1005             


Pro Glu  Lys Glu Asn Glu Asn  Asp Tyr Lys Glu Leu  His Tyr Thr 
    1010                 1015                 1020             


Ala Leu  Asn Met Glu Leu Gln  Glu Tyr Glu Lys Val  Arg Ser Lys 
    1025                 1030                 1035             


Glu Leu  Leu Lys Gln Val Gln  Glu Leu Glu Lys Lys  Ile Leu Glu 
    1040                 1045                 1050             


Glu Tyr  Thr Asp Phe Leu Ser  Thr Gln Ile His Pro  Ala Asp Phe 
    1055                 1060                 1065             


Glu Arg  Glu Gly Asn Pro Asn  Phe Lys Lys Tyr Leu  Ala His Ser 
    1070                 1075                 1080             


Ile Leu  Glu Asn Glu Asp Asp  Leu Asp Lys Leu Pro  Glu Lys Ala 
    1085                 1090                 1095             


Glu Ala  Met Arg Glu Leu Asp  Glu Thr Ile Thr Asn  Pro Ile Ile 
    1100                 1105                 1110             


Lys Lys  Ala Ile Val Leu Ile  Ile Ile Arg Asn Lys  Met Ala His 
    1115                 1120                 1125             


Asn Gln  Tyr Pro Pro Lys Phe  Ile Tyr Asp Leu Ala  Asn Arg Phe 
    1130                 1135                 1140             


Val Pro  Lys Lys Glu Glu Glu  Tyr Phe Ala Thr Tyr  Phe Asn Arg 
    1145                 1150                 1155             


Val Phe  Glu Thr Ile Thr Lys  Glu Leu Trp Glu Asn  Lys Glu Lys 
    1160                 1165                 1170             


Lys Asp  Lys Thr Gln Val 
    1175                 


<210>  1907
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1907

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Ala Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Asn Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1908
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1908

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1909
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1909

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Ala Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Asn Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1910
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1910

Leu Gln Lys Gln Asp Lys Leu Phe Val Asp Arg Lys Lys Asn Ala Ile 
1               5                   10                  15      


Phe Ala Phe Pro Lys Tyr Ile Thr Ile Met Glu Asn Lys Glu Lys Pro 
            20                  25                  30          


Glu Pro Ile Tyr Tyr Glu Leu Thr Asp Lys His Phe Trp Ala Ala Phe 
        35                  40                  45              


Leu Asn Leu Ala Arg His Asn Val Tyr Thr Thr Ile Asn His Ile Asn 
    50                  55                  60                  


Arg Arg Leu Glu Ile Ala Glu Leu Lys Asp Asp Gly Tyr Met Met Asp 
65                  70                  75                  80  


Ile Lys Gly Ser Trp Asn Glu Gln Ala Lys Lys Leu Asp Lys Lys Val 
                85                  90                  95      


Arg Leu Arg Asp Leu Leu Met Lys His Phe Pro Phe Leu Glu Ala Ala 
            100                 105                 110         


Ala Tyr Glu Met Thr Asn Ser Lys Ser Pro Asn Asn Lys Glu Gln Arg 
        115                 120                 125             


Glu Lys Glu Gln Ser Glu Ala Leu Ser Leu Asn Asn Leu Lys Asn Val 
    130                 135                 140                 


Leu Phe Ile Phe Leu Glu Lys Leu Gln Val Leu Arg Asn Tyr Tyr Ser 
145                 150                 155                 160 


His Tyr Lys Tyr Ser Glu Glu Ser Pro Lys Pro Ile Phe Glu Thr Ser 
                165                 170                 175     


Leu Leu Lys Asn Met Tyr Lys Val Phe Asp Ala Asn Val Arg Leu Val 
            180                 185                 190         


Lys Arg Asp Tyr Met His His Glu Asn Ile Asp Met Gln Arg Asp Phe 
        195                 200                 205             


Thr His Leu Asn Arg Lys Lys Gln Val Gly Arg Thr Lys Asn Ile Ile 
    210                 215                 220                 


Asp Ser Pro Asn Phe His Tyr His Phe Ala Asp Lys Glu Gly Asn Met 
225                 230                 235                 240 


Thr Ile Ala Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Asp Lys Lys 
                245                 250                 255     


Asp Ala Ile Trp Met Gln Lys Lys Leu Lys Gly Phe Lys Asp Gly Arg 
            260                 265                 270         


Asn Leu Arg Glu Gln Met Thr Asn Glu Val Phe Cys Arg Ser Arg Ile 
        275                 280                 285             


Ser Leu Pro Lys Leu Lys Leu Glu Asn Val Gln Thr Lys Asp Trp Met 
    290                 295                 300                 


Gln Leu Asp Met Leu Asn Glu Leu Val Arg Cys Pro Lys Ser Leu Tyr 
305                 310                 315                 320 


Glu Arg Leu Arg Glu Lys Asp Arg Glu Ser Phe Lys Val Pro Phe Asp 
                325                 330                 335     


Ile Phe Ser Asp Asp Tyr Asp Ala Glu Glu Glu Pro Phe Lys Asn Thr 
            340                 345                 350         


Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe 
        355                 360                 365             


Asp Leu Asn Glu Ile Phe Glu Gln Leu Arg Phe Gln Ile Asp Leu Gly 
    370                 375                 380                 


Thr Tyr His Phe Ser Ile Tyr Asn Lys Arg Ile Gly Asp Glu Asp Glu 
385                 390                 395                 400 


Val Arg His Leu Thr His His Leu Tyr Gly Phe Ala Arg Ile Gln Asp 
                405                 410                 415     


Phe Ala Pro Gln Asn Gln Pro Glu Glu Trp Arg Lys Leu Val Lys Asp 
            420                 425                 430         


Leu Asp His Phe Glu Thr Ser Gln Glu Pro Tyr Ile Ser Lys Thr Ala 
        435                 440                 445             


Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Lys Phe Cys Ser 
    450                 455                 460                 


Thr His Asn Asn Leu Phe Pro Ser Leu Lys Thr Glu Lys Thr Cys Asn 
465                 470                 475                 480 


Gly Arg Ser Lys Phe Asn Leu Gly Thr Gln Phe Thr Ala Glu Ala Phe 
                485                 490                 495     


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu 
            500                 505                 510         


Thr Lys Asp His Pro Lys Gly Lys Gly Ile Asn Lys Ile Glu Lys Ile 
        515                 520                 525             


Ile Arg Lys Glu Ile Ser Asn Ile Tyr Ala Ile Tyr Asp Ala Phe Ala 
    530                 535                 540                 


Asn Asn Glu Ile Asn Ser Ile Ala Asp Leu Thr Arg Arg Leu Gln Asn 
545                 550                 555                 560 


Thr Asn Ile Leu Gln Gly His Leu Pro Lys Gln Met Ile Ser Ile Leu 
                565                 570                 575     


Glu Gly Arg Gln Lys Asp Met Glu Lys Glu Ala Glu Arg Lys Ile Gly 
            580                 585                 590         


Glu Met Ile Asp Asp Thr Gln Arg Arg Leu Asp Leu Leu Cys Lys Gln 
        595                 600                 605             


Thr Asn Gln Lys Ile Arg Ile Gly Lys Arg Asn Ala Gly Leu Leu Lys 
    610                 615                 620                 


Ser Gly Lys Ile Ala Asp Trp Leu Val Asn Asp Met Met Arg Phe Gln 
625                 630                 635                 640 


Pro Val Gln Lys Asp Gln Asn Asn Ile Pro Ile Asn Asn Ser Lys Ala 
                645                 650                 655     


Asn Ser Thr Glu Tyr Arg Met Leu Gln Arg Ala Leu Ala Leu Phe Gly 
            660                 665                 670         


Ser Glu Asn Phe Arg Leu Lys Ala Tyr Phe Asn Gln Met Asn Leu Val 
        675                 680                 685             


Gly Asn Asp Asn Pro His Pro Phe Leu Ala Glu Thr Gln Trp Glu His 
    690                 695                 700                 


Gln Thr Asn Ile Leu Ser Phe Tyr Arg Asn Tyr Leu Glu Ala Arg Lys 
705                 710                 715                 720 


Lys Tyr Leu Lys Gly Leu Lys Pro Gln Asn Trp Lys Gln Tyr Gln His 
                725                 730                 735     


Phe Leu Ile Leu Lys Val Gln Lys Thr Asn Arg Asn Thr Leu Val Thr 
            740                 745                 750         


Gly Trp Lys Asn Ser Phe Asn Leu Pro Arg Gly Ile Phe Thr Gln Pro 
        755                 760                 765             


Ile Arg Glu Trp Phe Glu Lys His Asn Asn Ser Lys Arg Ile Tyr Asp 
    770                 775                 780                 


Gln Ile Leu Ser Phe Asp Arg Val Gly Phe Val Ala Lys Ala Ile Pro 
785                 790                 795                 800 


Leu Tyr Phe Ala Glu Glu Tyr Lys Asp Asn Val Gln Pro Phe Tyr Asp 
                805                 810                 815     


Tyr Pro Phe Asn Ile Gly Asn Lys Leu Lys Pro Gln Lys Gly Gln Phe 
            820                 825                 830         


Leu Asp Lys Lys Glu Arg Val Glu Leu Trp Gln Lys Asn Lys Glu Leu 
        835                 840                 845             


Phe Lys Asn Tyr Pro Ser Glu Lys Lys Lys Thr Asp Leu Ala Tyr Leu 
    850                 855                 860                 


Asp Phe Leu Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys 
865                 870                 875                 880 


Asn Gln Asp Ile Val Thr Trp Leu Met Phe Lys Glu Leu Phe Lys Thr 
                885                 890                 895     


Thr Thr Val Glu Gly Leu Lys Ile Gly Glu Ile His Leu Arg Asp Ile 
            900                 905                 910         


Asp Thr Asn Thr Ala Asn Glu Glu Ser Asn Asn Ile Leu Asn Arg Ile 
        915                 920                 925             


Met Pro Met Lys Leu Pro Val Lys Thr Tyr Glu Thr Asp Asn Lys Gly 
    930                 935                 940                 


Asn Ile Leu Lys Glu Arg Pro Leu Ala Thr Phe Tyr Ile Glu Glu Thr 
945                 950                 955                 960 


Glu Thr Lys Val Leu Lys Gln Gly Asn Phe Lys Val Leu Ala Lys Asp 
                965                 970                 975     


Arg Arg Leu Asn Gly Leu Leu Ser Phe Ala Glu Thr Thr Asp Ile Asp 
            980                 985                 990         


Leu Glu Lys Asn Pro Ile Thr Lys  Leu Ser Val Asp His  Glu Leu Ile 
        995                 1000                 1005             


Lys Tyr  Gln Thr Thr Arg Ile  Ser Ile Phe Glu Met  Thr Leu Gly 
    1010                 1015                 1020             


Leu Glu  Lys Lys Leu Ile Asp  Lys Tyr Ser Thr Leu  Pro Thr Asp 
    1025                 1030                 1035             


Ser Phe  Arg Asn Met Leu Glu  Arg Trp Leu Gln Cys  Lys Ala Asn 
    1040                 1045                 1050             


Arg Pro  Glu Leu Lys Asn Tyr  Val Asn Ser Leu Ile  Ala Val Arg 
    1055                 1060                 1065             


Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met Tyr Asp  Ala Thr Leu 
    1070                 1075                 1080             


Phe Ala  Glu Val Lys Lys Phe  Thr Leu Phe Pro Ser  Val Asp Thr 
    1085                 1090                 1095             


Lys Lys  Ile Glu Leu Asn Ile  Ala Pro Gln Leu Leu  Glu Ile Val 
    1100                 1105                 1110             


Gly Lys  Ala Ile Lys Glu Ile  Glu Lys Ser Glu Asn  Lys Asn 
    1115                 1120                 1125         


<210>  1911
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1911

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Val Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Ser Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1912
<211>  1157
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1912

Met Glu Asn Ile Glu Thr Lys Lys Asp Asn Lys Lys Thr Leu Asn Val 
1               5                   10                  15      


Asn Pro Glu Phe Phe Gly Thr Tyr Leu Asn Leu Ala Arg His Asn Val 
            20                  25                  30          


Phe Leu Ile Asn Asn Glu Leu Ala Asn Arg Phe Glu Ile Asn Ser Ile 
        35                  40                  45              


Leu Thr Thr Asp Glu Asn Ile Gly Ser Ser Phe Met Thr Asn Lys Ile 
    50                  55                  60                  


Thr Phe Asp Lys Thr Asn Ser Asn Leu Val Tyr Thr Asn Leu Val Arg 
65                  70                  75                  80  


Tyr Met Pro Val Ala Lys Ile Phe Ser Ser Asp Leu Leu Pro Lys Lys 
                85                  90                  95      


Ile Gln Glu Phe Ala Thr Phe Gln Gly Val Asp Ile Leu Lys Leu Thr 
            100                 105                 110         


Gln Phe Phe Lys Leu Ser Phe Ser Glu Leu Asn Ser Phe Arg Asn Asp 
        115                 120                 125             


Tyr Ser His Tyr Tyr Ser Ile Glu Thr Lys Thr Leu Lys Lys Thr Gln 
    130                 135                 140                 


Ile Ser Ala Asp Phe Ala Pro Leu Phe Lys Glu Ser Phe Ala Phe Ala 
145                 150                 155                 160 


Ile Glu Phe Ala Lys Ser Arg Phe Glu Thr Ile Phe Asp Lys Lys Asp 
                165                 170                 175     


Phe Glu Leu Val Glu Lys Met Glu Leu Ile Asp Ser Asn Asn Thr Ile 
            180                 185                 190         


Ser Asp Arg Gly Val Val Phe Leu Ala Cys Met Phe Leu Asp Lys Glu 
        195                 200                 205             


Asn Ala Phe Gln Phe Met Asn Lys Val Val Gly Phe Lys Ala Thr Asn 
    210                 215                 220                 


Asp Asn Ile Phe Leu Ala Thr Arg Glu Val Phe Ser Val Phe Cys Val 
225                 230                 235                 240 


Thr Leu Pro His Asp Lys Phe Leu Ser Asp Asn Pro Lys Gln Ala Leu 
                245                 250                 255     


Gln Leu Asp Met Leu Asn Tyr Leu Asn Arg Cys Pro Lys Glu Leu Phe 
            260                 265                 270         


Asn Ala Leu Ser Pro Ile Gly Lys Lys Gln Phe Gln Pro Asn Leu Ser 
        275                 280                 285             


Ala Ile Ala Ser Leu Asn Val Glu Asp Asn Ser Ile Asn Glu Ser Ile 
    290                 295                 300                 


Asp Phe Glu Asn Tyr Gln Asn Tyr Ile Glu Asn Ile Ser Thr Lys Lys 
305                 310                 315                 320 


Arg Ser Ser Asp Arg Phe Pro Tyr Phe Ala Leu Lys His Leu Ser Glu 
                325                 330                 335     


Asn Asn Lys Phe Asp Phe Asp Phe Gln Ile Asn Leu Gly Lys Val Leu 
            340                 345                 350         


Lys Lys Ser Tyr Lys Lys Val Val Leu Gly Ile Glu Pro Glu Glu Asn 
        355                 360                 365             


Asn Arg Asn Ile Val Glu Asn Ile Leu Val Phe Asn Asn Ile Ser Ile 
    370                 375                 380                 


Phe Glu Asn Lys Asn Asp Asp Glu Ile Leu Glu Ile Lys Lys Ser Ile 
385                 390                 395                 400 


Ile Asn Glu Pro Thr Phe Ile Lys Arg Phe Ser Asn Ile Asp Val Ser 
                405                 410                 415     


Asp Phe Glu Gln Phe Thr Pro His Phe Asn Thr Glu Asn Asn Lys Ile 
            420                 425                 430         


Gly Leu Leu Pro His Asp Asn Lys Met Phe Ala Asn Leu Leu Tyr Arg 
        435                 440                 445             


Pro Ile Val Pro Thr Ala Phe Leu Ser Thr His Glu Leu Pro Lys Val 
    450                 455                 460                 


Val Leu Leu Glu His Leu Glu Lys Gly Ser Ser Ser Gln Ile Ile Lys 
465                 470                 475                 480 


Ser Phe Ile Asp Ala Asn Thr Asn Val Ile Phe Asn Lys Ser Leu Val 
                485                 490                 495     


Glu Glu Ile Lys Glu Lys Leu Ala Phe Glu Arg Thr Leu Tyr Lys Val 
            500                 505                 510         


Phe Phe Asp Glu Lys Leu Lys Val Leu Asp Trp Lys Ala Asp Leu Glu 
        515                 520                 525             


Thr Gln Leu Asn Ser Leu Asn Asp Ser Ile Lys Lys Leu Lys Glu Thr 
    530                 535                 540                 


Gln Thr Val Thr Phe Asp Glu Lys Arg Asn Lys Asp Asn Ala Leu Lys 
545                 550                 555                 560 


Asn Lys Gln Phe Glu Arg Lys Ser Leu Asn Tyr Ala Leu Tyr Val Lys 
                565                 570                 575     


Arg Val Asn Glu Arg Lys Asn Ile Leu Asn Asn Val Leu Glu Lys Tyr 
            580                 585                 590         


Asn Leu Asp Ala Ser Gln Ile Pro Ser Ala Ile Ile Asp Tyr Trp Leu 
        595                 600                 605             


Lys Ile Asp Ser Val Lys Glu Glu Thr Thr Ile Lys Asn Lys Ile Arg 
    610                 615                 620                 


Ala Glu Lys Ser Glu Cys Arg Asp Arg Leu Lys Asp Ile Lys Asn Gly 
625                 630                 635                 640 


Lys Ser Pro Lys Ile Gly Glu Met Ala Thr Phe Leu Ala Arg Asp Ile 
                645                 650                 655     


Val Arg Leu Val Ile Asp Lys Asp Val Lys Lys Lys Ile Thr Ser Phe 
            660                 665                 670         


Tyr Tyr Asp Lys Leu Gln Glu Cys Leu Ala Leu Tyr Glu Asp Lys Asp 
        675                 680                 685             


Lys Lys Gln Leu Phe Ile Asp Leu Cys Asn Lys Glu Leu Gln Leu Phe 
    690                 695                 700                 


Asp Asn Gln Lys Gly His Pro Phe Leu Ser Asn Leu Asn Leu Gln Asp 
705                 710                 715                 720 


Ile His Arg Thr Lys Glu Leu Tyr Gln Lys Tyr Ile Glu Glu Lys Gly 
                725                 730                 735     


Glu Lys Thr Val Pro Glu Lys Tyr Tyr Asn Arg Lys Ser Asp Asn Trp 
            740                 745                 750         


Glu Phe Lys Glu Ile Glu Ala Asn Trp Met Tyr Lys Thr Phe Tyr Asn 
        755                 760                 765             


Lys Val Lys Asn Ile Glu Thr Gly Lys Asp Glu Thr Gln Ile Thr Ile 
    770                 775                 780                 


Pro Ile Asn Lys Pro Met Pro Ile Val Tyr Ser Lys Leu Leu Asp Lys 
785                 790                 795                 800 


Thr Asn Asp Phe Asp Lys Trp Phe Thr Asn Val Ser Ser Gly Cys Ile 
                805                 810                 815     


Thr Pro Glu Asn Pro Lys Pro Asn Pro Lys Pro Ile Asp Leu Pro Thr 
            820                 825                 830         


Asn Leu Phe Asp Asp Lys Leu Val Lys Leu Leu Lys Asn Lys Ile Gly 
        835                 840                 845             


Ile Ala Asp Asn Asp Thr Thr Val Tyr Asn Phe Ser Lys Leu Leu Glu 
    850                 855                 860                 


Met Trp Leu Ala Asp Ala Gln Pro Phe Tyr Asp Asn Asp Arg Glu Tyr 
865                 870                 875                 880 


Ile Val Phe Lys Asn Lys Pro Phe Glu Ala Ile Val Pro Ile Lys Leu 
                885                 890                 895     


Gly Thr Lys Asn Ser Phe Lys Asp Tyr Tyr Arg Glu Phe Val Glu Thr 
            900                 905                 910         


Thr Phe Arg Leu Lys Lys Gln Glu Ser Lys Gln Leu Gln Lys Ser Gln 
        915                 920                 925             


Val Glu Ala Val Phe Arg Asn Ala Ile Ser Glu Asn Glu Lys Ile Ile 
    930                 935                 940                 


Arg His Tyr Lys Thr Lys Asp Arg Ile Met Leu Leu Met Leu Lys Glu 
945                 950                 955                 960 


Thr Leu Thr Ala Asp Ile Asp Ile Lys Leu Ser Glu Ile Tyr Pro Lys 
                965                 970                 975     


Ser Leu Thr Asn Pro Leu Asp Ile Gln Ile Pro Ile Lys Gln Pro Ile 
            980                 985                 990         


Gly Asn Lys Phe Ile Thr Asp Thr  Arg Lys Arg Lys Glu  Tyr Ser Ile 
        995                 1000                 1005             


Phe Lys  Arg Tyr Leu Ser Asp  Arg Arg Leu Pro Ser  Leu Leu Thr 
    1010                 1015                 1020             


Tyr Phe  Asp Thr Val Glu Ile  Pro Phe Glu Thr Leu  Lys Leu Glu 
    1025                 1030                 1035             


Leu Asn  Asp Tyr Gln Thr Ser  Arg Ile Ser Ile Ala  Glu Ala Val 
    1040                 1045                 1050             


Phe Lys  Leu Glu Lys Ser Ile  Ile Asn Val Val Ser  Gln Gln Asp 
    1055                 1060                 1065             


Leu Gln  Glu Leu Glu Ser His  Ala Thr Glu Lys Ile  Ser Asn Ile 
    1070                 1075                 1080             


Gln Phe  Lys His Tyr Cys Asn  Trp Leu Ile Lys Asn  Glu Lys Ile 
    1085                 1090                 1095             


Asn Pro  Gln Gln Gln Leu Phe  Leu Glu Asn Val Arg  Asn Lys Phe 
    1100                 1105                 1110             


Leu His  Asn Gln Phe Pro Asp  Arg Glu Ile Val Glu  Gln His Leu 
    1115                 1120                 1125             


Gln Leu  Glu Gln Asn Ser Thr  Phe Ser Lys Gln Ile  Ala Asn His 
    1130                 1135                 1140             


Tyr Leu  Ser Ile Ile Glu Asn  Leu Ile Thr Asn Lys  Phe Asn 
    1145                 1150                 1155         


<210>  1913
<211>  1146
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1913

Met Glu Ser Ile Ile Gly Leu Gly Leu Ser Phe Asn Pro Tyr Lys Thr 
1               5                   10                  15      


Ala Asp Lys His Tyr Phe Gly Ser Phe Leu Asn Leu Ala Asp Asn Asn 
            20                  25                  30          


Leu Lys Ala Val Phe Ala Glu Phe Lys Glu Arg Ile Ser Asp Lys Ser 
        35                  40                  45              


Lys Asp Glu Asp Ile Ser Asn Leu Ile Glu Lys His Phe Ile Asp Asn 
    50                  55                  60                  


Met Ser Ile Val Asp Tyr Glu Lys Asn Ile Ser Ile Leu Asn Gly Tyr 
65                  70                  75                  80  


Leu Pro Ile Ile Asp Phe Leu Asp Asp Glu Leu Glu Asn Asn Leu Asn 
                85                  90                  95      


Thr Arg Val Lys Asn Phe Lys Lys Ser Phe Ile Ile Leu Ala Glu Ala 
            100                 105                 110         


Leu Glu Thr Leu Arg Asn Tyr Tyr Thr His Phe Tyr His Asp Pro Ile 
        115                 120                 125             


Thr Phe Gly Asp Asn Lys Glu Pro Leu Leu Glu Leu Leu Asp Glu Val 
    130                 135                 140                 


Leu Leu Lys Thr Ile Leu Asp Val Lys Lys Lys Tyr Leu Lys Thr Asp 
145                 150                 155                 160 


Lys Thr Lys Glu Ile Leu Lys Asp Ser Leu Arg Glu Glu Met Asp Leu 
                165                 170                 175     


Leu Val Ile Arg Lys Thr Asp Glu Leu Arg Glu Lys Lys Lys Thr Asn 
            180                 185                 190         


Pro Lys Phe Lys Phe Ser Thr Asp Pro Thr Gln Ile Arg Asn Ser Ile 
        195                 200                 205             


Phe Asn Asp Ala Phe Gln Gly Leu Leu Tyr Glu Asp Lys Glu Asn Asn 
    210                 215                 220                 


Gly Lys Thr Gln Val Ser Tyr Arg Ala Lys Thr Lys Leu Asn Pro Lys 
225                 230                 235                 240 


Asp Ile His Lys Gln Glu Glu Arg Asp Phe Glu Ile Pro Leu Ser Thr 
                245                 250                 255     


Ser Gly Ile Val Phe Leu Met Ser Leu Phe Leu Ser Lys Lys Glu Ile 
            260                 265                 270         


Glu Asp Phe Lys Ser Asn Ile Lys Gly Phe Lys Gly Lys Val Val Lys 
        275                 280                 285             


Asp Glu Asn His Asn Ser Leu Lys Tyr Met Ala Thr His Arg Val Tyr 
    290                 295                 300                 


Ser Ile Leu Ala Phe Lys Gly Leu Lys Tyr Arg Ile Lys Thr Asp Thr 
305                 310                 315                 320 


Phe Ser Lys Val Thr Leu Met Met Gln Met Ile Asp Glu Leu Ser Lys 
                325                 330                 335     


Val Pro Asp Cys Val Tyr Gln Asn Leu Ser Glu Thr Lys Gln Lys Asp 
            340                 345                 350         


Phe Ile Glu Asp Trp Asn Glu Tyr Leu Lys Asp Asn Glu Glu Asn Thr 
        355                 360                 365             


Glu Asn Leu Glu Asn Ser Arg Val Val His Pro Leu Ile Arg Lys Arg 
    370                 375                 380                 


Tyr Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe 
385                 390                 395                 400 


Ala Asn Phe Lys Thr Leu Lys Phe Gln Val Phe Met Gly Tyr Tyr Ile 
                405                 410                 415     


His Asp Gln Arg Thr Lys Thr Ile Gly Thr Thr Asn Ile Thr Thr Glu 
            420                 425                 430         


Arg Thr Val Lys Glu Lys Ile Asn Val Phe Gly Lys Leu Ser Lys Met 
        435                 440                 445             


Asp Asn Leu Lys Lys His Phe Phe Ser Gln Leu Ser Asp Glu Glu Asn 
    450                 455                 460                 


Thr Asp Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Phe Leu Thr Gln 
465                 470                 475                 480 


Ala Asp Asn Ser Pro Ala Asn Asn Ile Pro Ile Tyr Leu Glu Leu Lys 
                485                 490                 495     


Asn Gln Gln Ile Ile Lys Glu Lys Asp Asp Ile Lys Ala Glu Val Asn 
            500                 505                 510         


Asn Ser Gln Asn Arg Asn Pro Asn Lys Pro Ser Lys Arg Asp Leu Leu 
        515                 520                 525             


Asn Lys Ile Ser Asn Thr Asn Glu Asp Phe Tyr Gln Gly Asp Pro Thr 
    530                 535                 540                 


Ala Ile Leu Ser Leu Asn Glu Ile Pro Ala Leu Leu His Leu Phe Leu 
545                 550                 555                 560 


Val Gln Pro Asp Asn Lys Thr Gly Gln Gln Ile Glu Asn Ile Ile Arg 
                565                 570                 575     


Ile Lys Ile Glu Lys Gln Phe Asn Ser Ile Lys Asn Pro Ser Lys Asp 
            580                 585                 590         


Asp Lys Gly Val Pro Lys Ser Leu Phe Ala Asp Thr Asn Val Arg Val 
        595                 600                 605             


Asn Ala Ile Lys Leu Lys Lys Asp Leu Gly Glu Glu Leu Asp Met Leu 
    610                 615                 620                 


Asn Lys Lys Gln Ile Val Phe Lys Glu Asn Gln Lys Ala Ser Ser Asn 
625                 630                 635                 640 


Tyr Asp Glu Leu Leu Lys Lys His Gln Phe Thr Pro Lys Asn Lys Arg 
                645                 650                 655     


Pro Ala Leu Arg Lys Tyr Val Phe Tyr Asn Ser Glu Lys Gly Glu Glu 
            660                 665                 670         


Ala Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Lys Gly Phe 
        675                 680                 685             


Lys Thr Lys Trp Lys Gly Tyr Gln His Ser Glu Leu Gln Arg Lys Leu 
    690                 695                 700                 


Ala Phe Tyr Asp Arg His Thr Lys Gln Asp Ile Lys Glu Leu Leu Ser 
705                 710                 715                 720 


Gly Cys Glu Phe Asp His Phe Leu Leu Asp Ile Asn Ala Cys Phe Lys 
                725                 730                 735     


Glu Asp Asp Phe Glu Asp Phe Phe Ser Lys Tyr Leu Lys Asn Arg Ile 
            740                 745                 750         


Glu Thr Leu Asn Ile Ile Leu Lys Gln Leu His Asp Phe Lys Asn Glu 
        755                 760                 765             


Pro Thr Pro Leu Lys Gly Val Phe Lys Asn Cys Leu Lys Phe Leu Lys 
    770                 775                 780                 


Gln Lys Asn Tyr Val Thr Glu Asn Pro Glu Ile Ile Lys Lys Arg Ile 
785                 790                 795                 800 


Leu Ala Lys Pro Ala Phe Leu Pro Arg Gly Ile Phe Asp Glu Arg Pro 
                805                 810                 815     


Thr Met Lys Lys Gly Lys Asn Pro Leu Ile Asp Arg Asp Glu Phe Ala 
            820                 825                 830         


Lys Trp Phe Val Glu Tyr Leu Glu Asn Lys Asp Tyr Gln Lys Phe Tyr 
        835                 840                 845             


Asn Ser Glu Glu Tyr Arg Ile Arg Asp Ala Asp Phe Lys Lys Asn Ala 
    850                 855                 860                 


Val Ile Lys Lys Gln Lys Leu Lys Asp Phe Tyr Thr Leu Gln Met Val 
865                 870                 875                 880 


Asn Tyr Leu Leu Lys Glu Val Phe Gly Lys Asp Glu Met Asn Leu Gln 
                885                 890                 895     


Leu Ser Glu Leu Phe Gln Thr Arg Gln Glu Arg Leu Lys Leu Gln Gly 
            900                 905                 910         


Ile Ala Lys Lys Gln Met Asn Lys Glu Thr Gly Asp Ser Ser Glu Asn 
        915                 920                 925             


Thr Arg Asn Gln Thr Tyr Ile Trp Asn Lys Asp Val Pro Val Ser Phe 
    930                 935                 940                 


Phe Asn Gly Lys Val Thr Ile Asp Lys Val Lys Leu Lys Asn Ile Gly 
945                 950                 955                 960 


Lys Tyr Lys Arg Tyr Glu Arg Asp Glu Arg Val Lys Thr Phe Ile Gly 
                965                 970                 975     


Tyr Glu Val Asp Glu Lys Trp Met Met Tyr Leu Pro His Asn Trp Lys 
            980                 985                 990         


Asp Arg Tyr Ser Val Lys Pro Ile  Asn Val Ile Asp Leu  Gln Ile Gln 
        995                 1000                 1005             


Glu Tyr  Glu Glu Ile Arg Ser  His Glu Leu Leu Lys  Glu Ile Gln 
    1010                 1015                 1020             


Asn Leu  Glu Gln Tyr Ile Tyr  Asp His Thr Thr Asp  Lys Asn Thr 
    1025                 1030                 1035             


Leu Leu  Gln Asp Gly Asn Pro  Asn Phe Lys Met Tyr  Val Leu Asn 
    1040                 1045                 1050             


Gly Leu  Leu Thr Gly Ile Lys  Gln Val Asn Ile Ala  Asp Phe Ile 
    1055                 1060                 1065             


Val Leu  Lys Gln Asn Thr Asn  Phe Asp Lys Ile Asp  Phe Thr Gly 
    1070                 1075                 1080             


Ile Ala  Ser Cys Ser Glu Leu  Glu Lys Lys Thr Ile  Ile Leu Ile 
    1085                 1090                 1095             


Ala Ile  Arg Asn Lys Phe Ala  His Asn Gln Leu Pro  Asn Lys Thr 
    1100                 1105                 1110             


Ile Tyr  Asp Leu Ala Asn Glu  Phe Leu Lys Lys Glu  Lys Arg Glu 
    1115                 1120                 1125             


Thr Tyr  Ala Asn Tyr Tyr Leu  Lys Val Leu Lys Lys  Met Ile Ser 
    1130                 1135                 1140             


Asp Leu  Ala 
    1145     


<210>  1914
<211>  1206
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1914

Met Ser Ser Lys Asn Glu Ser Tyr Asn Lys Gln Lys Thr Phe Asn His 
1               5                   10                  15      


Tyr Lys Gln Glu Asp Lys Tyr Phe Phe Gly Gly Phe Leu Asn Asn Ala 
            20                  25                  30          


Glu Glu Asn Ile Ile Thr Ser Phe Lys Glu Ile Ala Lys Arg Leu Asn 
        35                  40                  45              


Ser Lys Glu Lys Asn Lys Pro Ile Glu Ile Leu Gln Glu Ile Leu Ser 
    50                  55                  60                  


Glu Asn Ile Ile Asp Thr Glu Trp Asp Arg Asn Ile Lys Val Ile Ala 
65                  70                  75                  80  


Glu Tyr Phe Pro Phe Val Lys Leu Leu Glu Thr Ile Thr Glu Arg Gln 
                85                  90                  95      


Tyr Lys Lys His Lys Asn Lys Leu Phe Phe Lys Glu Arg Asn Pro Arg 
            100                 105                 110         


Gln Asn Phe Lys Asn Leu Phe Leu Tyr Asn Cys Ile Ile Leu Phe Asn 
        115                 120                 125             


Ser Pro Leu Gln Leu Arg Asp Phe Tyr Thr His Phe Tyr His Arg Asn 
    130                 135                 140                 


Phe Ile Thr Ile Ser Phe Pro Asp Phe Arg Arg Thr Thr Ile Asp Asn 
145                 150                 155                 160 


Asn Ser Ile Thr Asp Tyr Ile Lys Asn Glu Ala Ile Gln His Ser Ala 
                165                 170                 175     


Gln Ser Asp Gly Val Asn Phe Ile Ala His Ser Ile Phe Glu Leu Leu 
            180                 185                 190         


Asp Glu Leu Lys Leu Glu Thr Val Ser Gln Val Asn Asn Gln Arg Ile 
        195                 200                 205             


Lys Pro Asn Glu Lys His Ser Phe Leu Lys Lys Asn Tyr Gln Asn Asp 
    210                 215                 220                 


Phe Thr Asp Leu Thr Glu Glu Glu Ile Ser Lys Lys Phe Lys Lys Val 
225                 230                 235                 240 


Phe Asn Gln Phe Trp Thr Phe Asn Asp Tyr Lys Gly Arg Met Val Leu 
                245                 250                 255     


Lys Asp Phe His Lys Ser His Phe Val Glu Lys Val Glu Glu Gly Ser 
            260                 265                 270         


Met Glu Gln Lys Pro Lys Lys Asp Phe Phe His Gln Lys Ile Ser Arg 
        275                 280                 285             


Ser Gly Phe Leu Phe Leu Leu Ser Leu Phe Val Asp Arg Lys Asn Ala 
    290                 295                 300                 


Glu Phe Ile Leu Asp Asn Ser Thr Tyr Phe Lys Ala Ser Phe Asp Leu 
305                 310                 315                 320 


Gln Lys Leu Ala Thr Arg Trp Val Tyr Thr Tyr Asn Cys Tyr Arg Gly 
                325                 330                 335     


Leu Lys Asn Thr Val Asn Thr Thr Phe Pro Lys Glu Thr Leu Leu Ser 
            340                 345                 350         


Lys Met Val Asp Tyr Leu Ser Lys Val Pro Asp Glu Val Tyr Gln Leu 
        355                 360                 365             


Leu Ser Thr Glu Gln Gln Glu Met Phe Leu Glu Asp Met Asn Glu Tyr 
    370                 375                 380                 


Met Arg Asp Asn Glu Glu Asn Asn Asp Ser Ser Glu Ala Ser Lys Val 
385                 390                 395                 400 


Val His Pro Val Ile Arg Lys Arg Tyr Ser Asn Glu Phe Asn Tyr Leu 
                405                 410                 415     


Ala Leu Ser Phe Ile Asp Gln Tyr Ile Gln Leu Pro Asn Leu Arg Phe 
            420                 425                 430         


Ala Ile Asn Leu Gly Thr Tyr Val His Asn Lys Lys Glu Lys Ile Val 
        435                 440                 445             


Gly Lys Gly Lys Thr Ser Ser Thr Ser Asn Arg Val Ile Lys Glu Asp 
    450                 455                 460                 


Ile Arg Ile Tyr Ala Arg Leu His Glu Ala Ile Asp Phe Lys Asn Asn 
465                 470                 475                 480 


Phe Phe Leu Lys Glu Asn Phe Ser Glu Asp Asn Lys Asp Gly Tyr Trp 
                485                 490                 495     


Glu Glu Phe Pro Asn Pro His Tyr Ala Ile Lys Asp Asn Asn Ile Gly 
            500                 505                 510         


Ile Tyr Phe Ile Asn Lys Asp Val Ile Gln Thr Asn Leu Glu Glu Arg 
        515                 520                 525             


Ser Asn Gly Lys Lys Lys Lys Ala Ser Ile Ile Glu Ile Leu Thr Glu 
    530                 535                 540                 


Thr Glu Ser Asp Thr Ile Lys Tyr Gly Lys Pro His Ala Leu Leu Ser 
545                 550                 555                 560 


Cys Tyr Glu Leu Ile Pro Leu Leu Phe Asp Tyr Phe Gln Lys Val Lys 
                565                 570                 575     


Asn Ser Arg Glu Lys Lys Leu Asn Glu Lys Glu Leu Glu Ala Ile Pro 
            580                 585                 590         


Ile Gln Ile Glu Asn Lys Ile Leu Ser Ala Ile Asn Ser Phe Thr Lys 
        595                 600                 605             


Ser Phe Glu Asn Tyr Ser Glu Gly Lys Asn Ile Leu Lys Ser Tyr Pro 
    610                 615                 620                 


Lys Lys Leu Ser Lys Thr Ser Asn Gln Thr Ser Phe Leu Glu Val Gln 
625                 630                 635                 640 


Asp Glu Asn Gly Asn Pro Ala Lys Lys Ile Phe Gln Asp Ile Asp Lys 
                645                 650                 655     


Glu Ile Gln Lys Ser Gln Asp Lys Leu Asp Ile Leu Lys Lys Asn Glu 
            660                 665                 670         


Asn Glu Phe Gln Asn Asn Glu Arg Lys Ala Thr Phe Ser Lys Lys Glu 
        675                 680                 685             


Ile Gly Glu Glu Ala Thr Trp Leu Ala Asn Asp Ile Leu Arg Phe Met 
    690                 695                 700                 


Pro Ser Ser Phe Lys Lys Asp Trp Lys Gly Tyr Glu His Ser His Leu 
705                 710                 715                 720 


Gln Tyr Leu Leu Ala Phe Tyr Glu Val Arg Lys Thr Glu Ile Phe Gln 
                725                 730                 735     


Leu Leu Asn Gln Lys Trp Pro Leu Tyr Glu Asp Asn Phe Met Gly Glu 
            740                 745                 750         


Ser Leu Arg Thr Phe Leu Asp Asn Arg Lys Thr Phe Glu Ser Phe Tyr 
        755                 760                 765             


Lys Gly Tyr Leu Asp Lys Arg Lys Glu Ile Phe Glu Asn Leu Lys Asn 
    770                 775                 780                 


Asn Leu Ser Leu Asn Asn Asp Asn Leu Phe Arg Val Phe Asp Glu Arg 
785                 790                 795                 800 


Lys Tyr Thr Thr Lys Cys Leu Glu Cys Tyr Lys Lys Leu Ile Leu Glu 
                805                 810                 815     


Gln Pro Val Ser Phe Ser Arg Gly Ile Phe Glu Asp Lys Lys Ala Ala 
            820                 825                 830         


Ile Lys Asn Glu Trp Ser Leu Ile Pro Lys Asp Pro Ala Thr Glu Tyr 
        835                 840                 845             


Gln Ser Phe Tyr Asn Leu Ile Asn Ile Tyr Thr Asn Glu Ala Ile Asp 
    850                 855                 860                 


Lys Glu Glu Lys Lys Glu Lys Tyr Lys Asn Leu Arg Ala Ile Asn Lys 
865                 870                 875                 880 


Val Lys Ile Gln Asp Tyr Tyr Leu Lys Leu Met Val Asp Thr Leu Tyr 
                885                 890                 895     


Gln Asp Leu Phe Asn Leu Pro Leu Asp Lys Ser Leu Ser Asp Phe Tyr 
            900                 905                 910         


Val Ser Lys Ala Glu Arg Glu Lys Ile Lys Ala Asp Ala Lys Ala Tyr 
        915                 920                 925             


Gln Lys Arg Asn Asp Ser Ser Leu Trp Asn Lys Val Ile His Leu Ser 
    930                 935                 940                 


Leu Gln Asn Asn Arg Ile Thr Ala Asn Pro Lys Leu Lys Asp Ile Gly 
945                 950                 955                 960 


Lys Tyr Lys Arg Ala Leu Gln Asp Glu Lys Ile Ala Thr Leu Leu Thr 
                965                 970                 975     


Tyr Asp Asp Arg Thr Trp Ser Tyr Ala Leu Gln Lys Pro Glu Lys Glu 
            980                 985                 990         


Asn Glu Asn Asp Tyr Lys Glu Leu  His Tyr Thr Ala Leu  Asn Met Glu 
        995                 1000                 1005             


Leu Gln  Glu Tyr Glu Lys Val  Arg Ser Lys Lys Leu  Leu Lys Gln 
    1010                 1015                 1020             


Val Gln  Gln Leu Glu Lys Gln  Ile Leu Asp Lys Phe  Tyr Asp Phe 
    1025                 1030                 1035             


Ser Asn  Asn Ala Thr His Pro  Glu Asp Leu Glu Ile  Glu Asp Lys 
    1040                 1045                 1050             


Lys Gly  Lys Arg His Pro Asn  Phe Lys Leu Tyr Ile  Thr Lys Ala 
    1055                 1060                 1065             


Leu Leu  Lys Asn Glu Ser Glu  Ile Ile Asn Leu Glu  Asn Ile Asp 
    1070                 1075                 1080             


Ile Glu  Ile Leu Ile Lys Tyr  Tyr Asp Tyr Asn Thr  Glu Lys Leu 
    1085                 1090                 1095             


Lys Glu  Lys Ile Lys Asn Met  Asp Glu Asp Glu Lys  Ala Lys Ile 
    1100                 1105                 1110             


Val Asn  Thr Lys Glu Asn Tyr  Asn Lys Ile Thr Asn  Val Leu Ile 
    1115                 1120                 1125             


Lys Lys  Ala Leu Val Leu Ile  Ile Ile Arg Asn Lys  Met Ala His 
    1130                 1135                 1140             


Asn Gln  Tyr Pro Pro Lys Phe  Ile Tyr Asp Leu Ala  Thr Ser Phe 
    1145                 1150                 1155             


Gln Asn  Asp Lys Arg Asn Lys  Asp Trp Glu Lys Phe  Val His Gln 
    1160                 1165                 1170             


Lys Glu  Ser Glu Tyr Phe Ala  Thr Tyr Phe Asn Arg  Val Phe Glu 
    1175                 1180                 1185             


Thr Ile  Thr Thr Glu Leu Trp  Glu Asn Lys Lys Glu  Lys Ala Lys 
    1190                 1195                 1200             


Glu Ile  Val 
    1205     


<210>  1915
<211>  1107
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1915

Met Asn Ile Pro Lys Leu Val Glu Asp Lys Lys Arg Tyr Phe Gly Thr 
1               5                   10                  15      


Tyr Thr Val Met Ala Leu Met Asn Ala Gln Thr Val Leu Asp His Ile 
            20                  25                  30          


Gln Lys Val Thr Glu Leu Pro Ile Ile Pro Ala Ile Asn Lys Glu Gly 
        35                  40                  45              


Lys Glu Phe Thr Pro Pro Glu Glu Asp Leu Trp Gln His Pro Val Met 
    50                  55                  60                  


Arg Tyr Ile Asn His Val Ala Tyr Lys Gln Asp Asp Gln Pro Glu Lys 
65                  70                  75                  80  


Thr Gln Ala Val Ile Glu Lys Leu Leu His His Phe Ser Phe Leu Lys 
                85                  90                  95      


Ile Met Ala Glu Asn Gln Arg Asp Tyr Trp Asn Lys Lys Asn Asn Thr 
            100                 105                 110         


His Arg Leu Glu Val Asn Ser Thr Asp Leu Asn Gly Ile Leu Asn Thr 
        115                 120                 125             


Val Phe Arg Val Ile Lys Lys Tyr Arg Asp Thr Thr Thr His Tyr Met 
    130                 135                 140                 


Thr Asn Asp Thr Cys Trp Asn Asp Gly Ser Asp Phe Leu Ala Lys Glu 
145                 150                 155                 160 


Gln Arg Leu Ala Phe Met Ile Asp Asn Tyr Tyr Glu Val Ala Leu Arg 
                165                 170                 175     


Asp Leu Lys Glu Arg Tyr Ser Tyr Thr Thr Asp Asp Leu Arg Phe Ile 
            180                 185                 190         


Gln Tyr Tyr Arg Tyr Lys Arg Val Arg Met Pro Asp Gly Lys Pro Thr 
        195                 200                 205             


Met Cys Lys Asn Thr Asn Phe Tyr Leu Ser Met Val Asp Tyr Asn Gly 
    210                 215                 220                 


Asp Ala Gly Lys Lys Leu His Leu Ser Gly Val Gly Val Ala Gln Leu 
225                 230                 235                 240 


Val Cys Leu Phe Leu Asp Lys Gln Tyr Ile Asn Gln Leu Ala Ser Asn 
                245                 250                 255     


Leu Glu Leu Thr Ser Lys His Leu Pro Ser Ser Lys Glu Ala Gln Ile 
            260                 265                 270         


Ile Arg Arg Ser Leu Gly Ile His Asn Ile Val Leu Pro Lys Asp Arg 
        275                 280                 285             


Ile His Ser Asp Lys Gly Glu Met Ser Ile Ala Met Asp Met Leu Gly 
    290                 295                 300                 


Glu Ile Lys Arg Cys Pro Asn Glu Leu Phe Asp Thr Leu Ser Ala Asp 
305                 310                 315                 320 


Arg Gln Ser Ser Phe Arg Leu Ile Ser Ser Asp His Asn Glu Val Leu 
                325                 330                 335     


Leu Lys Arg Ser Ser Asp Arg Phe Ala Gln Leu Thr Leu Gln Tyr Ile 
            340                 345                 350         


Asp Tyr Gly Glu Lys Phe Asp Arg Ile Arg Phe His Val Asn Met Gly 
        355                 360                 365             


Lys Leu Arg Tyr Leu Phe Asn Ala Glu Lys Thr Cys Val Asp Gly Gln 
    370                 375                 380                 


Val Arg Val Arg Val Ile Glu His Pro Leu Asn Gly Phe Gly Arg Met 
385                 390                 395                 400 


Ala Glu Met Glu Ala Met Arg Lys Gln Glu Asp Gly Thr Phe Gly Lys 
                405                 410                 415     


Thr Gly Ile Gln Ile Arg Asp Phe Asp Asn Val Lys Arg Asp Asp Ala 
            420                 425                 430         


Asn Pro Ala Asn Tyr Pro Tyr Ile Val Asp Thr Tyr Thr His Tyr Met 
        435                 440                 445             


Leu Asp Asp Asn His Val Glu Met Leu Ile Gly Lys Pro Met Asp Met 
    450                 455                 460                 


Pro Glu Ile Glu Glu Tyr Asp Gly Lys Trp Tyr Val Asn Lys Thr Val 
465                 470                 475                 480 


Pro Ser Cys Arg Met Ser Thr Leu Glu Leu Pro Ala Met Met Phe His 
                485                 490                 495     


Met His Leu Leu Gly Ser Lys Arg Thr Glu Ala Arg Ile Ile Asp Phe 
            500                 505                 510         


Tyr Glu Arg Tyr Cys Lys Leu Phe Asp Ala Leu Lys Gln Gly Ala Val 
        515                 520                 525             


Ser Lys Glu Asn Ile Gly Glu Phe Gly Ile Lys Glu Gln Asp Met Pro 
    530                 535                 540                 


Gln Thr Val Leu Asp Val Ile Asn Gly Asn Ala Gln Gly Lys Asn Ala 
545                 550                 555                 560 


Asn Glu Tyr Ile Leu Lys Thr Leu Gln Glu Leu Tyr Asp His Ala Cys 
                565                 570                 575     


Lys Arg Ile Asp Asn Leu Arg Gln Asp Lys Arg Ala Ile Gly Ser Ala 
            580                 585                 590         


Ala Asn Lys Met Gly Lys Arg Gly Tyr Arg Gln Ile Lys Pro Gly Lys 
        595                 600                 605             


Leu Ala Glu Tyr Leu Ile Gln Asp Ile Val Arg Trp Gln Pro Thr Leu 
    610                 615                 620                 


Ser Ala Gly Asp Asp Tyr Gly Thr Asp Arg Leu Thr Gly Leu Asn Tyr 
625                 630                 635                 640 


Arg Val Met Gln Ala Ala Ile Ala Thr Tyr Asp Ser Arg Gly Lys Asp 
                645                 650                 655     


Glu Glu Ala Arg Arg Phe Lys Ala Met Phe Glu Arg Ala Asn Leu Ile 
            660                 665                 670         


Gly Gly Asp Arg Gln Lys Asn His Pro Phe Leu Tyr Lys Val Phe Gly 
        675                 680                 685             


Tyr Arg Leu Pro Ala Asp Ile Val Asp Phe Tyr Glu Lys Tyr Leu Asn 
    690                 695                 700                 


Glu Gln Lys Tyr Tyr Ile Asn Ser Leu Leu Lys Lys Ala Lys Gln Gly 
705                 710                 715                 720 


Glu Val Val Asn Val Pro Phe Val Asn Arg Asp Gln Ser Lys Trp Lys 
                725                 730                 735     


Lys Pro Thr Gln Glu Tyr Leu Gly Ala Glu Tyr Met Ala Asp Lys Ala 
            740                 745                 750         


Ile Glu Leu Pro Arg Gln Met Phe Asp Glu Asp Ile Lys Asn His Leu 
        755                 760                 765             


Lys Thr Leu Asp Gln Met Lys Asp Val Asp Phe Asp His Ala Asn Val 
    770                 775                 780                 


Thr Tyr Leu Ile Gly Glu Tyr Met Lys Arg Val Arg Asp Asp Ala Phe 
785                 790                 795                 800 


Gln Glu Phe Tyr Ala Trp Arg Arg Asn Tyr Arg Tyr Ile Asp Leu Leu 
                805                 810                 815     


Lys Cys Glu Val Asp Arg Thr Lys Arg Ile Pro Lys Leu Val Glu Thr 
            820                 825                 830         


Trp Thr Thr Thr Glu Glu Arg Glu Lys Ile Trp Lys Glu Arg Glu Lys 
        835                 840                 845             


Leu Ala Lys Glu Tyr Arg Ser Trp Ala Asp Gly Gln Met Lys Asn Asn 
    850                 855                 860                 


Pro Gln Thr Arg Arg Leu Thr Glu Asp Glu Arg Gly Glu Ile Ile Ala 
865                 870                 875                 880 


Lys Arg Leu Ser Asn Ser Arg Asn Asp Tyr Gln Arg Ser Glu Lys Met 
                885                 890                 895     


Ile Arg Arg Tyr Lys Val Gln Asp Ala Leu Leu Phe Ile Ala Ala Asn 
            900                 905                 910         


Asp Thr Leu Thr Gln His Met Asp Phe Lys Gly Lys Gln Phe Lys Leu 
        915                 920                 925             


Lys Asp Ile Thr Pro Asp Ala Glu Arg Gly Ile Leu Ser Glu Lys Met 
    930                 935                 940                 


Ser Met Asp Phe Lys Phe Glu Lys Asn Gly Lys Thr Tyr Ile Ile Tyr 
945                 950                 955                 960 


Ala Gln Glu Met Lys Ile Lys Asn Tyr Gly Asp Phe Phe Val Leu Ala 
                965                 970                 975     


Asn Asp Lys Arg Leu Val Asn Leu Leu Ala Leu Val Asn Gln Asp Arg 
            980                 985                 990         


Val Ser Lys Asp Glu Ile Glu Gln  Glu Leu Lys Arg Tyr  Asp Val Cys 
        995                 1000                 1005             


Arg Pro  Glu Val Val Lys Met  Ile Leu Asp Leu Glu  Lys Trp Ala 
    1010                 1015                 1020             


Phe Asp  Asn Phe Pro Glu Leu  Lys Ala Lys Val Met  Asn Asp Arg 
    1025                 1030                 1035             


Glu Asp  Asn Lys Val Gly Phe  Asn Tyr Ile Leu Asp  Val Leu Leu 
    1040                 1045                 1050             


Glu Asn  Lys Arg Ile Gly Glu  Ala Gln Lys Glu Thr  Leu Arg Leu 
    1055                 1060                 1065             


Ile Arg  Asn Ala Phe Asp His  Asn Asn Tyr Pro Arg  Thr Gly Val 
    1070                 1075                 1080             


Val Asn  Val Val Thr Leu Pro  Glu Ile Ala Glu Glu  Met Arg Asp 
    1085                 1090                 1095             


Leu Phe  Gly Glu Tyr Ala Arg  Ile Glu 
    1100                 1105         


<210>  1916
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1916

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Ile Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1917
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1917

Leu Gln Lys Gln Asp Lys Leu Phe Val Asp Arg Lys Lys Asn Ala Ile 
1               5                   10                  15      


Phe Ala Phe Pro Lys Tyr Ile Thr Ile Met Glu Asn Gln Glu Lys Pro 
            20                  25                  30          


Glu Pro Ile Tyr Tyr Glu Leu Thr Asp Lys His Phe Trp Ala Ala Phe 
        35                  40                  45              


Leu Asn Leu Ala Arg His Asn Val Tyr Thr Thr Ile Asn His Ile Asn 
    50                  55                  60                  


Arg Arg Leu Glu Ile Ala Glu Leu Lys Asp Asp Gly Tyr Met Met Asp 
65                  70                  75                  80  


Ile Lys Gly Ser Trp Asn Glu Gln Ala Lys Lys Leu Asp Lys Lys Val 
                85                  90                  95      


Arg Leu Arg Asp Leu Ile Met Lys His Phe Pro Phe Leu Glu Ala Ala 
            100                 105                 110         


Ala Tyr Glu Ile Thr Asn Ser Lys Ser Pro Asn Asn Lys Glu Gln Arg 
        115                 120                 125             


Glu Lys Glu Gln Ser Glu Ala Leu Ser Leu Asn Asn Leu Lys Asn Val 
    130                 135                 140                 


Leu Phe Ile Phe Leu Glu Lys Leu Gln Val Leu Arg Asn Tyr Tyr Ser 
145                 150                 155                 160 


His Tyr Lys Tyr Ser Glu Glu Ser Pro Lys Pro Ile Phe Glu Thr Ser 
                165                 170                 175     


Leu Leu Lys Asn Met Tyr Lys Val Phe Asp Ala Asn Val Arg Leu Val 
            180                 185                 190         


Lys Arg Asp Tyr Met His His Glu Asn Ile Asp Met Gln Arg Asp Phe 
        195                 200                 205             


Thr His Leu Asn Arg Lys Lys Gln Val Gly Arg Thr Lys Asn Ile Ile 
    210                 215                 220                 


Asp Ser Pro Asn Phe His Tyr His Phe Ala Asp Lys Glu Gly Asn Met 
225                 230                 235                 240 


Thr Ile Ala Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Asp Lys Lys 
                245                 250                 255     


Asp Ala Ile Trp Met Gln Lys Lys Leu Lys Gly Phe Lys Asp Gly Arg 
            260                 265                 270         


Asn Leu Arg Glu Gln Met Thr Asn Glu Val Phe Cys Arg Ser Arg Ile 
        275                 280                 285             


Ser Leu Pro Lys Leu Lys Leu Glu Asn Val Gln Thr Lys Asp Trp Met 
    290                 295                 300                 


Gln Leu Asp Met Leu Asn Glu Leu Val Arg Cys Pro Lys Ser Leu Tyr 
305                 310                 315                 320 


Glu Arg Leu Arg Glu Lys Asp Arg Glu Ser Phe Lys Val Pro Phe Asp 
                325                 330                 335     


Ile Phe Ser Asp Asp Tyr Asp Ala Glu Glu Glu Pro Phe Lys Asn Thr 
            340                 345                 350         


Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe 
        355                 360                 365             


Asp Leu Asn Glu Ile Phe Glu Gln Leu Arg Phe Gln Ile Asp Leu Gly 
    370                 375                 380                 


Thr Tyr His Phe Ser Ile Tyr Asn Lys Arg Ile Gly Asp Glu Asp Glu 
385                 390                 395                 400 


Val Arg His Leu Thr His His Leu Tyr Gly Phe Ala Arg Ile Gln Asp 
                405                 410                 415     


Phe Ala Gln Gln Asn Gln Pro Glu Val Trp Arg Lys Leu Val Lys Asp 
            420                 425                 430         


Leu Asp Tyr Phe Glu Ala Ser Gln Glu Pro Tyr Ile Pro Lys Thr Ala 
        435                 440                 445             


Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Lys Phe Cys Ser 
    450                 455                 460                 


Thr His Asn Asn Leu Phe Pro Ser Leu Lys Thr Glu Lys Thr Cys Asn 
465                 470                 475                 480 


Gly Arg Ser Lys Phe Asn Leu Gly Thr Gln Phe Thr Ala Glu Ala Phe 
                485                 490                 495     


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu 
            500                 505                 510         


Thr Lys Asp Tyr Ser Arg Lys Glu Ser Ala Asp Lys Val Glu Gly Ile 
        515                 520                 525             


Ile Arg Lys Glu Ile Ser Asn Ile Tyr Ala Ile Tyr Asp Ala Phe Ala 
    530                 535                 540                 


Asn Gly Glu Ile Asn Ser Ile Ala Asp Leu Thr Cys Arg Leu Gln Lys 
545                 550                 555                 560 


Thr Asn Ile Leu Gln Gly His Leu Pro Lys Gln Met Ile Ser Ile Leu 
                565                 570                 575     


Glu Gly Arg Gln Lys Asp Met Glu Lys Glu Ala Glu Arg Lys Ile Gly 
            580                 585                 590         


Glu Met Ile Asp Asp Thr Gln Arg Arg Leu Asp Leu Leu Cys Lys Gln 
        595                 600                 605             


Thr Asn Gln Lys Ile Arg Ile Gly Lys Arg Asn Ala Gly Leu Leu Lys 
    610                 615                 620                 


Ser Gly Lys Ile Ala Asp Trp Leu Val Asn Asp Met Met Arg Phe Gln 
625                 630                 635                 640 


Pro Val Gln Lys Asp Gln Asn Asn Ile Pro Ile Asn Asn Ser Lys Ala 
                645                 650                 655     


Asn Ser Thr Glu Tyr Arg Met Leu Gln Arg Ala Leu Ala Leu Phe Gly 
            660                 665                 670         


Ser Glu Asn Phe Arg Leu Lys Ala Tyr Phe Asn Gln Met Asn Leu Val 
        675                 680                 685             


Gly Asn Asp Asn Pro His Pro Phe Leu Ala Glu Thr Gln Trp Glu His 
    690                 695                 700                 


Gln Thr Asn Ile Leu Ser Phe Tyr Arg Asn Tyr Leu Glu Ala Arg Lys 
705                 710                 715                 720 


Lys Tyr Leu Lys Gly Leu Lys Pro Gln Asn Trp Lys Gln Tyr Gln His 
                725                 730                 735     


Phe Leu Ile Leu Lys Val Gln Lys Thr Asn Arg Asn Thr Leu Val Thr 
            740                 745                 750         


Gly Trp Lys Asn Ser Phe Asn Leu Pro Arg Gly Ile Phe Thr Gln Pro 
        755                 760                 765             


Ile Arg Glu Trp Phe Glu Lys His Asn Asn Ser Lys Arg Ile Tyr Asp 
    770                 775                 780                 


Gln Ile Leu Ser Phe Asp Arg Val Gly Phe Val Ala Lys Ala Ile Pro 
785                 790                 795                 800 


Leu Tyr Phe Ala Glu Glu Tyr Lys Asp Asn Val Gln Pro Phe Tyr Asp 
                805                 810                 815     


Tyr Pro Phe Asn Ile Gly Asn Lys Leu Lys Pro Gln Lys Gly Gln Phe 
            820                 825                 830         


Leu Asp Lys Lys Glu Arg Val Glu Leu Trp Gln Lys Asn Lys Glu Leu 
        835                 840                 845             


Phe Lys Asn Tyr Pro Ser Glu Lys Lys Lys Thr Asp Leu Ala Tyr Leu 
    850                 855                 860                 


Asp Phe Leu Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys 
865                 870                 875                 880 


Asn Gln Asp Ile Val Thr Trp Leu Met Phe Lys Glu Leu Phe Asn Met 
                885                 890                 895     


Ala Thr Val Glu Gly Leu Lys Ile Gly Glu Ile His Leu Arg Asp Ile 
            900                 905                 910         


Asp Thr Asn Thr Ala Asn Glu Glu Ser Asn Asn Ile Leu Asn Arg Ile 
        915                 920                 925             


Met Pro Met Lys Leu Pro Val Lys Thr Tyr Glu Thr Asp Asn Lys Gly 
    930                 935                 940                 


Asn Ile Leu Lys Glu Arg Pro Leu Ala Thr Phe Tyr Ile Glu Glu Thr 
945                 950                 955                 960 


Glu Thr Lys Val Leu Lys Gln Gly Asn Phe Lys Val Leu Ala Lys Asp 
                965                 970                 975     


Arg Arg Leu Asn Gly Leu Leu Ser Phe Ala Glu Thr Thr Asp Ile Asp 
            980                 985                 990         


Leu Glu Lys Asn Pro Ile Thr Lys  Leu Ser Val Asp His  Glu Leu Ile 
        995                 1000                 1005             


Lys Tyr  Gln Thr Thr Arg Ile  Ser Ile Phe Glu Met  Thr Leu Gly 
    1010                 1015                 1020             


Leu Glu  Lys Lys Leu Ile Asn  Lys Tyr Pro Thr Leu  Pro Thr Asp 
    1025                 1030                 1035             


Ser Phe  Arg Asn Met Leu Glu  Arg Trp Leu Gln Cys  Lys Ala Asn 
    1040                 1045                 1050             


Arg Pro  Glu Leu Lys Asn Tyr  Val Asn Ser Leu Ile  Ala Val Arg 
    1055                 1060                 1065             


Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met Tyr Asp  Ala Thr Leu 
    1070                 1075                 1080             


Phe Ala  Glu Val Lys Lys Phe  Thr Leu Phe Pro Ser  Val Asp Thr 
    1085                 1090                 1095             


Lys Lys  Ile Glu Leu Asn Ile  Ala Pro Gln Leu Leu  Glu Ile Val 
    1100                 1105                 1110             


Gly Lys  Ala Ile Lys Glu Ile  Glu Lys Ser Glu Asn  Lys Asn 
    1115                 1120                 1125         


<210>  1918
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1918

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Met Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Met Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1919
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1919

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Val Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Ser Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1920
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1920

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Thr 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1921
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1921

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Thr 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1922
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1922

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe His Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Arg Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Met Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1923
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1923

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Val Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Ser Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1924
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1924

Leu Gln Lys Gln Asp Lys Leu Phe Val Asp Arg Lys Lys Asn Ala Ile 
1               5                   10                  15      


Phe Ala Phe Pro Lys Tyr Ile Thr Ile Met Glu Asn Lys Glu Lys Pro 
            20                  25                  30          


Glu Pro Ile Tyr Tyr Glu Leu Thr Asp Lys His Phe Trp Ala Ala Phe 
        35                  40                  45              


Leu Asn Leu Ala Arg His Asn Val Tyr Thr Thr Ile Asn His Ile Asn 
    50                  55                  60                  


Arg Arg Leu Glu Ile Ala Glu Leu Lys Asp Asp Gly Tyr Met Met Gly 
65                  70                  75                  80  


Ile Lys Gly Ser Trp Asn Glu Gln Ala Lys Lys Leu Asp Lys Lys Val 
                85                  90                  95      


Arg Leu Arg Asp Leu Ile Met Lys His Phe Pro Phe Leu Glu Ala Ala 
            100                 105                 110         


Ala Tyr Glu Met Thr Asn Ser Lys Ser Pro Asn Asn Lys Glu Gln Arg 
        115                 120                 125             


Glu Lys Glu Gln Ser Glu Ala Leu Ser Leu Asn Asn Leu Lys Asn Val 
    130                 135                 140                 


Leu Phe Ile Phe Leu Glu Lys Leu Gln Val Leu Arg Asn Tyr Tyr Ser 
145                 150                 155                 160 


His Tyr Lys Tyr Ser Glu Glu Ser Pro Lys Pro Ile Phe Glu Thr Ser 
                165                 170                 175     


Leu Leu Lys Asn Met Tyr Lys Ile Phe Asp Thr Asn Val Arg Leu Val 
            180                 185                 190         


Lys Arg Asp Tyr Met His His Glu Asn Val Asp Met Gln Arg Asp Phe 
        195                 200                 205             


Ser His Leu Asn Arg Lys Lys Gln Glu Gly Gln Thr Arg Lys Ile Ile 
    210                 215                 220                 


Ala Asn Pro Asn Phe Arg Tyr His Phe Ala Asp Glu Lys Gly Asp Met 
225                 230                 235                 240 


Thr Ile Ala Gly Leu Leu Phe Phe Ile Ser Leu Phe Leu Asp Lys Lys 
                245                 250                 255     


Asp Ala Ile Trp Met Gln Lys Lys Leu Lys Gly Phe Lys Asp Gly Arg 
            260                 265                 270         


Asn Leu Arg Glu Gln Met Thr Asn Glu Val Phe Cys Arg Ser Arg Ile 
        275                 280                 285             


Ser Leu Pro Lys Leu Lys Leu Glu Asn Val Gln Thr Lys Asp Trp Met 
    290                 295                 300                 


Gln Leu Asp Met Leu Asn Glu Leu Val Arg Cys Pro Lys Ser Leu Tyr 
305                 310                 315                 320 


Glu Arg Leu Arg Glu Lys Asp Arg Glu Ser Phe Lys Val Pro Phe Asp 
                325                 330                 335     


Ile Phe Ser Asp Asp Tyr Asp Ala Glu Glu Glu Pro Phe Lys Asn Thr 
            340                 345                 350         


Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe 
        355                 360                 365             


Asp Leu Asn Glu Ile Phe Glu Gln Leu Arg Phe Gln Ile Asp Leu Gly 
    370                 375                 380                 


Thr Tyr His Phe Ser Ile Tyr Asn Lys Arg Ile Gly Asp Glu Asp Glu 
385                 390                 395                 400 


Val Arg His Leu Thr His His Leu Tyr Gly Phe Ala Arg Ile Gln Asp 
                405                 410                 415     


Phe Ala Pro Gln Asn Gln Pro Glu Glu Trp Arg Lys Leu Val Lys Asp 
            420                 425                 430         


Leu Asp His Phe Glu Thr Ser Gln Lys Pro Tyr Ile Ser Lys Thr Ala 
        435                 440                 445             


Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Lys Phe Cys Ser 
    450                 455                 460                 


Thr His Asn Asn Leu Phe Pro Ser Leu Lys Thr Glu Lys Thr Cys Asn 
465                 470                 475                 480 


Gly Arg Ser Lys Phe Asn Leu Gly Thr Gln Phe Thr Ala Glu Ala Phe 
                485                 490                 495     


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu 
            500                 505                 510         


Thr Lys Asp His Pro Lys Gly Lys Gly Ile Asn Lys Ile Glu Lys Ile 
        515                 520                 525             


Ile Arg Thr Glu Ile Ser Asn Ile Tyr Asp Ile Tyr Asp Ala Phe Ala 
    530                 535                 540                 


Asn Gly Glu Ile Asn Ser Ile Ala Asp Leu Thr Cys Arg Leu Gln Lys 
545                 550                 555                 560 


Thr Asn Ile Leu Gln Gly His Leu Pro Lys Gln Met Ile Ser Ile Leu 
                565                 570                 575     


Glu Gly Arg Gln Lys Asp Met Glu Lys Glu Ala Glu Arg Lys Ile Gly 
            580                 585                 590         


Glu Met Ile Asp Asp Thr Gln Arg Arg Leu Asp Leu Leu Cys Lys Gln 
        595                 600                 605             


Thr Asn Gln Lys Ile Arg Ile Gly Lys Arg Asn Ala Gly Leu Leu Lys 
    610                 615                 620                 


Ser Gly Lys Ile Ala Asp Trp Leu Val Asn Asp Met Met Arg Phe Gln 
625                 630                 635                 640 


Pro Val Gln Lys Asp Gln Asn Asn Ile Pro Ile Asn Asn Ser Lys Ala 
                645                 650                 655     


Asn Ser Thr Glu Tyr Arg Met Leu Gln Arg Ala Leu Ala Leu Phe Gly 
            660                 665                 670         


Ser Glu Asn Phe Arg Leu Lys Ala Tyr Phe Asn Gln Met Asn Leu Val 
        675                 680                 685             


Gly Asn Asp Asn Pro His Pro Phe Leu Ala Glu Thr Gln Trp Glu His 
    690                 695                 700                 


Gln Thr Asn Ile Leu Ser Phe Tyr Arg Asn Tyr Leu Glu Ala Arg Lys 
705                 710                 715                 720 


Lys Tyr Leu Lys Gly Leu Lys Pro Gln Asn Trp Lys Gln Tyr Gln His 
                725                 730                 735     


Phe Leu Ile Leu Lys Val Gln Lys Thr Asn Arg Asn Thr Leu Val Thr 
            740                 745                 750         


Gly Trp Lys Asn Ser Phe Asn Leu Pro Arg Gly Ile Phe Thr Gln Pro 
        755                 760                 765             


Ile Arg Glu Trp Phe Glu Lys His Asn Asn Ser Lys Arg Ile Tyr Asp 
    770                 775                 780                 


Gln Ile Leu Ser Phe Asp Arg Val Gly Phe Val Ala Lys Ala Ile Pro 
785                 790                 795                 800 


Leu Tyr Phe Ala Glu Glu Tyr Lys Asp Asn Val Gln Pro Phe Tyr Asp 
                805                 810                 815     


Tyr Pro Phe Asn Ile Gly Asn Lys Leu Lys Pro Gln Lys Gly Gln Phe 
            820                 825                 830         


Leu Asp Lys Lys Glu Arg Val Glu Leu Trp Gln Lys Asn Lys Glu Leu 
        835                 840                 845             


Phe Lys Asn Tyr Pro Ser Glu Lys Lys Lys Thr Asp Leu Ala Tyr Leu 
    850                 855                 860                 


Asp Phe Leu Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys 
865                 870                 875                 880 


Asn Gln Asp Ile Val Thr Trp Leu Met Phe Lys Glu Leu Phe Lys Thr 
                885                 890                 895     


Thr Thr Val Glu Gly Leu Lys Ile Gly Glu Ile His Leu Arg Asp Ile 
            900                 905                 910         


Asp Thr Asn Thr Ala Asn Glu Glu Ser Asn Asn Ile Leu Asn Arg Ile 
        915                 920                 925             


Met Pro Met Lys Leu Pro Val Lys Thr Tyr Glu Thr Asp Asn Lys Gly 
    930                 935                 940                 


Asn Ile Leu Lys Glu Arg Pro Leu Ala Thr Phe Tyr Ile Glu Glu Thr 
945                 950                 955                 960 


Glu Thr Lys Val Leu Lys Gln Gly Asn Phe Lys Val Leu Ala Lys Asp 
                965                 970                 975     


Arg Arg Leu Asn Gly Leu Leu Ser Phe Ala Glu Thr Thr Asp Ile Asp 
            980                 985                 990         


Leu Glu Lys Asn Pro Ile Thr Lys  Leu Ser Val Asp His  Glu Leu Ile 
        995                 1000                 1005             


Lys Tyr  Gln Thr Thr Arg Ile  Ser Ile Phe Glu Met  Thr Leu Gly 
    1010                 1015                 1020             


Leu Glu  Lys Lys Leu Ile Asp  Lys Tyr Ser Thr Leu  Pro Thr Asp 
    1025                 1030                 1035             


Ser Phe  Arg Asn Met Leu Glu  Arg Trp Leu Gln Cys  Lys Ala Asn 
    1040                 1045                 1050             


Arg Pro  Glu Leu Lys Asn Tyr  Val Asn Ser Leu Ile  Ala Val Arg 
    1055                 1060                 1065             


Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met Tyr Asp  Ala Thr Leu 
    1070                 1075                 1080             


Phe Ala  Glu Val Lys Lys Phe  Thr Leu Phe Pro Ser  Val Asp Thr 
    1085                 1090                 1095             


Lys Lys  Ile Glu Leu Asn Ile  Ala Pro Gln Leu Leu  Glu Ile Val 
    1100                 1105                 1110             


Gly Lys  Ala Ile Lys Glu Ile  Glu Lys Ser Glu Asn  Lys Asn 
    1115                 1120                 1125         


<210>  1925
<211>  1090
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1925

Met Asn Ile Pro Ala Leu Val Glu Asn Gln Lys Lys Tyr Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Val Met Ala Met Leu Asn Ala Gln Thr Val Leu Asp His Ile 
            20                  25                  30          


Gln Lys Val Ala Asp Ile Glu Gly Glu Gln Asn Glu Asn Asn Glu Asn 
        35                  40                  45              


Leu Trp Phe His Pro Ile Met Ser His Leu Tyr Asn Ala Lys Asn Gly 
    50                  55                  60                  


Tyr Asp Lys Gln Pro Glu Lys Thr Met Phe Ile Ile Glu Arg Leu Gln 
65                  70                  75                  80  


Ser Tyr Phe Pro Phe Leu Lys Ile Met Ala Glu Ser Gln Arg Glu Tyr 
                85                  90                  95      


Ser Asn Lys Lys Asn Lys Gln Asn Arg Val Glu Val Asn Ser Asn Asp 
            100                 105                 110         


Ile Phe Glu Val Leu Lys Arg Ala Phe Gly Val Leu Lys Met Tyr Arg 
        115                 120                 125             


Asp Gln Thr Asn His Tyr Lys Thr Tyr Asp Glu Lys Leu Ile Asp Gly 
    130                 135                 140                 


Cys Glu Phe Leu Thr Arg Thr Glu Leu Pro Leu Ser Gly Met Ile Asn 
145                 150                 155                 160 


Ser Tyr Tyr Thr Val Ala Leu Arg Asn Ile Lys Glu Arg Tyr Gly Tyr 
                165                 170                 175     


Lys Thr Glu Asp Leu Ala Phe Ile Gln Asp Asn Arg Tyr Lys Phe Val 
            180                 185                 190         


Lys Asp Ala Tyr Gly Lys Arg Lys Ser Gln Val Asn Thr Gly Phe Phe 
        195                 200                 205             


Leu Ser Leu Gln Asp Tyr Asn Gly Asp Met Thr Lys Lys Leu His Leu 
    210                 215                 220                 


Ser Gly Val Gly Ile Ala Leu Leu Ile Cys Leu Phe Leu Asp Lys Gln 
225                 230                 235                 240 


Tyr Ile Asn Leu Phe Leu Ser Arg Leu Pro Ile Phe Ser Ser Tyr Asn 
                245                 250                 255     


Ala Gln Ser Glu Glu Arg Arg Ile Ile Ile Arg Ser Phe Gly Ile Asn 
            260                 265                 270         


Ser Ile Lys Gln Pro Lys Asp Arg Ile His Ser Glu Lys Ser Asn Lys 
        275                 280                 285             


Ser Val Ala Met Asp Met Leu Asn Glu Val Lys Arg Cys Pro Asp Glu 
    290                 295                 300                 


Leu Phe Thr Thr Leu Ser Ala Glu Lys Gln Ser Arg Phe Arg Ile Ile 
305                 310                 315                 320 


Ser Asp Asp His Asn Glu Val Leu Met Lys Arg Ser Ser Asp Arg Phe 
                325                 330                 335     


Val Gln Leu Leu Leu Gln Tyr Ile Asp Tyr Gly Lys Leu Phe Lys Asn 
            340                 345                 350         


Ile Arg Phe His Val Asn Met Gly Lys Leu Arg Tyr Leu Leu Lys Ala 
        355                 360                 365             


Asp Lys Glu Cys Ile Asp Gly Gln Thr Arg Val Arg Val Ile Glu Gln 
    370                 375                 380                 


Pro Leu Asn Gly Phe Gly Arg Leu Asp Glu Val Glu Val Leu Arg Lys 
385                 390                 395                 400 


Gln Glu Asn Gly Thr Phe Gly Lys Ser Gly Ile Arg Ile Arg Asp Phe 
                405                 410                 415     


Glu Asn Met Lys Arg Asp Asp Asp Asn Pro Ala Asp Tyr Pro Tyr Ile 
            420                 425                 430         


Val Asp Thr Tyr Thr His Tyr Met Leu Glu Asn Asn Lys Val Glu Met 
        435                 440                 445             


Tyr Ile Ser Lys Asp Asp Asn Pro Ala Pro Leu Leu Pro Glu Ile Glu 
    450                 455                 460                 


Asp Asn Arg Tyr Ala Val Lys Thr Ile Pro Ser Cys Arg Ile Ser Thr 
465                 470                 475                 480 


Leu Glu Phe Pro Ala Met Ala Phe His Met Phe Leu Leu Gly Ser Glu 
                485                 490                 495     


Arg Thr Glu Arg Arg Ile Lys Asp Val Tyr Asp Arg Tyr Lys Lys Leu 
            500                 505                 510         


Phe Glu Ala Met His Lys Glu Glu Val Thr Ala Glu Asn Ile Ala Ser 
        515                 520                 525             


Phe Gly Ile Ala Glu Arg Asp Leu Pro Lys Lys Ile Leu Asp Ile Ile 
    530                 535                 540                 


Asn Gly Asn Ala Gln Gly Lys Asp Val Asp Ala Tyr Ile Lys Ala Thr 
545                 550                 555                 560 


Ile Asp Asn Met Ile Ala Asp Thr Glu His Arg Ile Lys Lys Leu Lys 
                565                 570                 575     


Asp Asp Arg Lys Ala Val Arg Ser Val Asp Asn Lys Met Gly Lys Arg 
            580                 585                 590         


Ser Phe Lys Arg Ile Ser Thr Gly Lys Leu Ala Asp Phe Leu Ala Lys 
        595                 600                 605             


Asp Ile Val Met Phe Gln Pro Ser Lys Asn Tyr Gly Glu Asn Lys Ile 
    610                 615                 620                 


Thr Gly Leu Asn Tyr Arg Ile Met Gln Ser Ala Ile Ala Val Tyr Asp 
625                 630                 635                 640 


Ser Gly Asp Asn Tyr Glu Ala Lys Gln Gln Phe Arg Leu Met Phe Glu 
                645                 650                 655     


Asn Ala Gln Leu Ile Gly Lys Gly Ile Thr Glu Ala His Pro Phe Leu 
            660                 665                 670         


Tyr Lys Val Phe Ala Arg Ser Val Pro Ala Asn Ala Val Asp Phe Tyr 
        675                 680                 685             


Glu Arg Tyr Leu Ile Glu Arg Lys Tyr Tyr Leu Thr Ala Leu Phe Asn 
    690                 695                 700                 


Glu Ile Lys Lys Gly Asn Lys Val Asp Ile Pro Phe Ile Arg Arg Asn 
705                 710                 715                 720 


Gln Asn Lys Trp Lys Thr Pro Val Met Lys Thr Leu Gly Arg Ile Tyr 
                725                 730                 735     


Asn Glu Asp Leu Pro Val Glu Leu Pro Arg Gln Met Phe Asp Asp Glu 
            740                 745                 750         


Ile Lys Ser His Leu Lys Ser Leu Ser Gln Met Ser Ser Ile Asp Phe 
        755                 760                 765             


Asp Asn Ala Asn Val Thr Tyr Leu Ile Ala Glu Tyr Met Lys Arg Val 
    770                 775                 780                 


Leu Gly Asp Asp Phe Gln Asn Phe Tyr Gln Trp Asn Arg Asn Tyr Arg 
785                 790                 795                 800 


Tyr Met Asp Met Leu Lys Gly Glu Tyr Asp Ser Lys Gly Thr Leu Leu 
                805                 810                 815     


Cys Asn Phe Thr Ser Val Glu Glu Arg Glu Ala Leu Trp Lys Glu Arg 
            820                 825                 830         


Glu Asp Arg Ser Gly Ser Tyr Arg Lys Leu Ala Thr Lys Lys Ile Lys 
        835                 840                 845             


Ser Asn Arg Leu Met Arg Asn Ala Ser Thr Asp Glu Val Asn Ser Ile 
    850                 855                 860                 


Leu Asp Lys Arg Leu Ser Asn Ser Arg Asn Glu Tyr Gln Lys Asn Glu 
865                 870                 875                 880 


Lys Ile Ile Arg Arg Tyr Lys Val Gln Asp Ala Leu Leu Phe Leu Leu 
                885                 890                 895     


Ala Lys Lys Ser Leu Thr Glu Met Ala Asp Phe Asp Gly Asn Lys Phe 
            900                 905                 910         


Lys Leu Lys Glu Ile Met Pro Asp Thr Glu Lys Gly Ile Leu Ser Glu 
        915                 920                 925             


Ile Met Pro Met Thr Phe Thr Phe Glu Lys Gly Gly Glu Arg Tyr Thr 
    930                 935                 940                 


Ile Thr Ser Glu Gly Met Lys Leu Lys Asn Tyr Gly Asp Phe Phe Val 
945                 950                 955                 960 


Leu Ala Asn Asp Lys Arg Leu Cys Lys Leu Leu Lys Ile Val Asp Ser 
                965                 970                 975     


Asp Thr Val Ser Lys Glu Asp Ile Met Glu Glu Phe Lys Arg Tyr Asp 
            980                 985                 990         


Gln Cys Arg Pro Glu Ile Ala Ser  Ile Val Phe Asn Leu  Glu Lys Trp 
        995                 1000                 1005             


Ala Phe  Asp Thr Tyr Pro Glu  Leu Ser Ala Lys Val  Asp Arg Glu 
    1010                 1015                 1020             


Glu Gln  Val Asp Phe Lys Phe  Ile Leu Asn Val Leu  Leu Asn Lys 
    1025                 1030                 1035             


Lys Asn  Ile Asn Asn Glu Gln  Ser Tyr Ile Leu Arg  Lys Ile Arg 
    1040                 1045                 1050             


Asn Ala  Phe Asp His Asn Asn  Tyr Pro Asp Lys Gly  Leu Val Glu 
    1055                 1060                 1065             


Ile Lys  Ala Leu Pro Glu Ile  Ala Met Ser Ile Lys  Lys Thr Phe 
    1070                 1075                 1080             


Gly Glu  Tyr Ala Ile Met Lys  
    1085                 1090 


<210>  1926
<211>  1214
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1926

Leu Ile Leu Ser Phe Ile Ile Phe Asn Phe Ile Val Ile Ile Asn Gln 
1               5                   10                  15      


His Thr Leu Asn Thr Tyr Thr Arg Lys Tyr Met Lys Asp Lys Ser Phe 
            20                  25                  30          


Ser Thr Ile Ser Ser Ala Ile Asn Glu Thr Ile Thr Thr Asp Asn Ile 
        35                  40                  45              


Lys Tyr Pro Glu Gln Leu Asn Leu Ile Leu Ser Lys Arg Leu Arg Pro 
    50                  55                  60                  


Lys Asn Glu Leu Gln Pro Leu Trp Ala Ala Tyr Phe Asn Met Ala Arg 
65                  70                  75                  80  


Tyr Asn Met Tyr Thr Thr Leu Val His Ile Ala Thr Ala Thr Gly Leu 
                85                  90                  95      


Ser Asp Glu Asp Asn Met Glu Asn Arg Met Asp Lys Met Arg Ile Leu 
            100                 105                 110         


Asn Glu Pro Val Glu Pro Glu Ile Glu His Arg Leu Arg Lys Leu Leu 
        115                 120                 125             


Cys Arg His Phe Pro Phe Ala Val Trp Met Ile Cys Asn Pro Ile Arg 
    130                 135                 140                 


Lys Lys Asp Ser Lys Glu Asp Ser Ala Asp Glu Asp Tyr Arg Val Ile 
145                 150                 155                 160 


Ser Val Lys Glu Leu Arg Asp Cys Leu Lys Thr Val Ser Tyr Thr Leu 
                165                 170                 175     


Asn Tyr Phe Arg Asn Tyr Tyr Ser His Thr Arg His Val Glu Thr Arg 
            180                 185                 190         


Ser Glu Asp Ile Ile Ala Ala Ser Arg Asn Ser Glu Lys Gln Thr Gly 
        195                 200                 205             


Ile Phe Leu Asn Lys Val Cys Thr Val Ala Thr Arg Arg Val Lys Ser 
    210                 215                 220                 


Arg Phe Ser Asp Lys Ser Asn Lys Gly Gln Ala Gly Met Ile Asp Asp 
225                 230                 235                 240 


Gln Ser Met Lys Phe Ile Thr Glu Gly Lys Val Lys Phe Arg Asn Asn 
                245                 250                 255     


Asn Gly Ile Lys Glu Thr Ile Tyr Asn Pro Asp His Phe Leu Tyr Pro 
            260                 265                 270         


Leu Phe Leu Asn Arg Ser Ser Ala Leu Arg Asp Gly Thr Asn Pro Glu 
        275                 280                 285             


Arg Leu Ser Thr Val Gly Lys Ile Gln Leu Ile Cys Leu Leu Leu Asp 
    290                 295                 300                 


Lys Lys Tyr Ile Thr Glu Phe Leu Asp Gln Ser Gly Phe Leu Ser Ala 
305                 310                 315                 320 


Phe Asn Asn Asn Ala Pro Ala Pro Lys Leu Ser Glu Arg Arg Leu Ile 
                325                 330                 335     


Leu Glu Val Leu Ser Asp Leu Arg Ile Arg Leu Pro Gln Arg Lys Ile 
            340                 345                 350         


Asp Ala Thr Cys Asn Asp Ile Gln Val Ala Leu Asp Met Leu Asn Glu 
        355                 360                 365             


Leu Lys Lys Cys Pro Lys Glu Leu Phe Glu Leu Leu Glu Ala Lys Asp 
    370                 375                 380                 


Lys Ala Thr Phe Ser Ile Leu Ser Ser Thr Gly Glu His Ile Leu Leu 
385                 390                 395                 400 


Arg Arg Ser Ser Asp Arg Phe Thr Gln Leu Ala Leu Gln Trp Phe Asp 
                405                 410                 415     


Val Asn Lys Ala Phe Ser Arg Ile Arg Phe His Met Asn Ala Gly Ile 
            420                 425                 430         


Phe Arg Tyr Leu Phe Asn Asp Ser Lys Thr Cys Ile Asp Gly Lys Thr 
        435                 440                 445             


Arg Leu Arg Val Leu Gln Glu Pro Leu Asn Cys Phe Gly Arg Ile Gln 
    450                 455                 460                 


Glu Val Glu Asp Ser Arg Glu Ser Asn Arg Asp Gly Asn Asp Gly Pro 
465                 470                 475                 480 


Trp Arg Gly Phe Glu Ile Lys Gly Phe Asp Glu Ala Ala Arg Asn Asp 
                485                 490                 495     


Val Asn Cys Leu Pro Tyr Ile Asn Asp Ser Arg Thr Arg Tyr Leu Ile 
            500                 505                 510         


Thr Glu Asp Asn Ile Gly Ile Arg Phe Ser Gly Asn Asp Glu Ala Cys 
        515                 520                 525             


Gly Asn Tyr Phe Pro Arg Ile Asp Glu Lys Asn Gly Lys Tyr Lys Val 
    530                 535                 540                 


Thr Cys Leu Pro Ala Gln Cys Met Ile Ser Ile Tyr Glu Leu Gln Ala 
545                 550                 555                 560 


Met Leu Phe Leu His Leu Leu Asn Pro Gly Asn Asp Gly Gly Ile Ala 
                565                 570                 575     


Pro Val Glu Lys Ile Ile Ile Asp Lys Val Glu Ser Tyr Arg Arg Phe 
            580                 585                 590         


Phe Ser Asp Ile Lys Asn Gly Leu Leu Thr Pro Ser Gly Leu Thr Glu 
        595                 600                 605             


Ser Ser Leu Asn Asp Lys Leu Thr Ser Thr Tyr Gly Ile Ser Leu Ser 
    610                 615                 620                 


Asp Ile Pro Asp Lys Met Lys Asp Tyr Leu Leu Lys Lys Asn Asn Lys 
625                 630                 635                 640 


Gly Arg Gly Phe Asn Ala Tyr Arg Asp Arg Leu Ile Glu Thr Leu Lys 
                645                 650                 655     


Glu Glu Thr Glu Tyr Arg Ile Lys Arg Leu Glu Glu Asn Leu Asn Ala 
            660                 665                 670         


Thr Asn Ser Asp Thr Asn Lys Pro Gly Lys Pro Gly Tyr Val Gln Ile 
        675                 680                 685             


Lys Pro Gly Ser Leu Ala Ser Phe Ile Ser Lys Asp Ile Val Phe Phe 
    690                 695                 700                 


Gln Glu Cys Asn Ala Asp Gln Lys Met Thr Gly Leu Asn Phe Ser Val 
705                 710                 715                 720 


Met Gln Gly Leu Ile Ala Thr Phe Gly Ser Gln Glu Gly Ala Thr Thr 
                725                 730                 735     


Asp Asp Leu Arg Met Ala Phe Arg Lys Ser Gly Leu Ile Ala Ala Asn 
            740                 745                 750         


Gly Ser Cys Gly Thr His Pro Phe Leu Ala Ile Ala Phe Asn Ala Gly 
        755                 760                 765             


Ala Lys Asn Thr Val Asp Leu Tyr Lys Glu Tyr Leu Asn Ala Arg Lys 
    770                 775                 780                 


Ser Tyr Leu Ser Gly Ile Ile Pro Asp Asn Ala Pro Phe Leu His Ala 
785                 790                 795                 800 


Asp Arg Ile Arg Trp Ala Val Asn Asp Asp Ala Tyr Tyr Lys Asp Tyr 
                805                 810                 815     


Ala Glu Arg Cys Leu Gln Arg Pro Val Ile Leu Pro Arg Arg Leu Phe 
            820                 825                 830         


Glu Ala Ser Ile Arg Glu Asn Leu Leu Ala Leu Asn Gly Glu Asn Ala 
        835                 840                 845             


Asn Ala Leu Lys Lys Val Ile Ile Gly Ala Gly Gly His Cys Asn Ser 
    850                 855                 860                 


Ala Phe Met Ile Asp Ser Tyr Phe Tyr Tyr Val Lys Asn Asp Ser Pro 
865                 870                 875                 880 


Gln Val Phe His Gly Ala Cys Glu Gly Asp Met Leu His Thr Tyr Gly 
                885                 890                 895     


His Arg Phe Phe Gln Val Val Arg Arg Asn Leu Lys Asn Ala Glu Ala 
            900                 905                 910         


Ile Leu Ser Lys Leu Lys Lys Asp Ser Asn Thr His Asn Thr Tyr Ile 
        915                 920                 925             


Gly Ala Leu Ser Asp Ala Ile Cys Trp Ala Lys Glu Asn Pro Ile Lys 
    930                 935                 940                 


Pro Thr Phe Ser Val Gly Arg Ser Arg Leu Asn Asn His Ser Glu Asn 
945                 950                 955                 960 


Glu Ile Ala Ala Met Ile Lys Arg Ala Phe Asn Glu Tyr Met Ala Thr 
                965                 970                 975     


Glu Lys Thr Leu Arg Arg Tyr Val Ile Gln Asp Glu Leu Leu Phe Leu 
            980                 985                 990         


Ala Ala Met Lys Thr Ile Lys Ser  Lys Leu Gly Val Pro  Asp Ser Glu 
        995                 1000                 1005             


Trp Lys  Leu Gly Ser Ile Gly  Ser Lys Ser Gly Ser  Ile Leu Asp 
    1010                 1015                 1020             


Lys Glu  Leu Pro Leu Ile Gln  Thr Pro Ala Lys Phe  Ser Asn Ile 
    1025                 1030                 1035             


Lys Arg  Arg Pro Asn Lys Thr  Ile Thr Lys Asp Leu  Val Glu Leu 
    1040                 1045                 1050             


Val Ile  Glu Gln His Asn Val  Ser Ile Lys Asp Tyr  Gly Glu Ile 
    1055                 1060                 1065             


Tyr Arg  Ile Leu Ala Asp Glu  Arg Leu Tyr Gly Leu  Leu Lys Tyr 
    1070                 1075                 1080             


His Lys  Asn Glu Thr Val Leu  Ala Ser Asp Leu Lys  Asn Glu Ile 
    1085                 1090                 1095             


Glu Lys  Tyr Asp Glu Lys Arg  Val Lys Val Phe Glu  Asp Ile Met 
    1100                 1105                 1110             


Asn Tyr  Glu Lys Lys Ile Thr  Asn Gly Val Thr Asp  Arg Gln Leu 
    1115                 1120                 1125             


Cys Glu  Ser Met Asp His Ala  Lys Asp Ile Asp Phe  Lys Val Met 
    1130                 1135                 1140             


Gln Thr  Phe Asp Thr Met Asn  Asp Asn Leu Thr Lys  Met Glu Leu 
    1145                 1150                 1155             


Arg Ser  Ile Arg Asn Ala Phe  Cys His Asn Ser Tyr  Pro Asp Val 
    1160                 1165                 1170             


Asn Ala  Phe Asp Asn Ser Ser  Gly Thr Thr Lys Arg  Ile Arg Ile 
    1175                 1180                 1185             


His Asn  Ala Asp Ile Pro Gly  Thr Ala Glu Lys Ile  Ser Glu Ile 
    1190                 1195                 1200             


Val Asn  Asp Ile Ser Ser Lys  Thr Glu Ala Lys 
    1205                 1210                 


<210>  1927
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1927

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Thr 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1928
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1928

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Leu Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1929
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1929

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Ala Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Asn Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1930
<211>  1146
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1930

Met Glu Ser Ile Ile Gly Leu Gly Leu Ser Phe Asn Pro Tyr Lys Thr 
1               5                   10                  15      


Ala Asp Lys His Tyr Phe Gly Ser Phe Leu Asn Leu Ala Asp Asn Asn 
            20                  25                  30          


Leu Lys Ala Val Phe Ala Glu Phe Lys Glu Arg Ile Ser Asp Lys Ser 
        35                  40                  45              


Lys Asp Glu Asp Ile Ser Asn Leu Ile Glu Lys His Phe Ile Asp Asn 
    50                  55                  60                  


Met Ser Ile Val Asp Tyr Glu Lys Asn Ile Ser Ile Leu Asn Gly Tyr 
65                  70                  75                  80  


Leu Pro Ile Ile Asp Phe Leu Asp Asp Glu Leu Glu Asn Asn Leu Asn 
                85                  90                  95      


Thr Arg Val Lys Asn Phe Lys Lys Ser Phe Ile Ile Leu Ala Glu Ala 
            100                 105                 110         


Leu Glu Thr Leu Arg Asn Tyr Tyr Thr His Phe Tyr His Asp Pro Ile 
        115                 120                 125             


Thr Phe Gly Asp Asn Lys Glu Pro Leu Leu Glu Leu Leu Asp Glu Val 
    130                 135                 140                 


Leu Leu Lys Thr Ile Leu Asp Val Lys Lys Lys Tyr Leu Lys Thr Asp 
145                 150                 155                 160 


Lys Thr Lys Glu Ile Leu Lys Asp Ser Leu Arg Glu Glu Met Asp Leu 
                165                 170                 175     


Leu Val Ile Arg Lys Thr Asp Glu Leu Arg Glu Lys Lys Lys Thr Asn 
            180                 185                 190         


Pro Lys Phe Lys Phe Ser Thr Asp Pro Thr Gln Ile Arg Asn Ser Ile 
        195                 200                 205             


Phe Asn Asp Ala Phe Gln Gly Leu Leu Tyr Glu Asp Lys Glu Asn Asn 
    210                 215                 220                 


Gly Lys Thr Gln Val Ser Tyr Arg Ala Lys Thr Lys Leu Asn Pro Lys 
225                 230                 235                 240 


Asp Ile His Lys Gln Glu Glu Arg Asp Phe Glu Ile Pro Leu Ser Thr 
                245                 250                 255     


Ser Gly Ile Val Phe Leu Met Ser Leu Phe Leu Ser Lys Lys Glu Ile 
            260                 265                 270         


Glu Asp Phe Lys Ser Asn Ile Lys Gly Phe Lys Gly Lys Val Val Lys 
        275                 280                 285             


Asp Glu Asn His Asn Ser Leu Lys Tyr Met Ala Thr His Arg Val Tyr 
    290                 295                 300                 


Ser Ile Leu Ala Phe Lys Gly Leu Lys Tyr Arg Ile Lys Thr Asp Thr 
305                 310                 315                 320 


Phe Ser Lys Val Thr Leu Met Met Gln Met Ile Asp Glu Leu Ser Lys 
                325                 330                 335     


Val Pro Asp Cys Val Tyr Gln Asn Leu Ser Glu Thr Lys Gln Lys Asp 
            340                 345                 350         


Phe Ile Glu Asp Trp Asn Glu Tyr Leu Lys Asp Asn Glu Glu Asn Thr 
        355                 360                 365             


Glu Asn Leu Glu Asn Ser Arg Val Val His Pro Leu Ile Arg Lys Arg 
    370                 375                 380                 


Tyr Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe 
385                 390                 395                 400 


Ala Asn Phe Lys Thr Leu Lys Phe Gln Val Phe Met Gly Tyr Tyr Ile 
                405                 410                 415     


His Asp Gln Arg Thr Lys Thr Ile Gly Thr Thr Asn Ile Thr Thr Glu 
            420                 425                 430         


Arg Thr Val Lys Glu Lys Ile Asn Val Phe Gly Lys Leu Ser Lys Met 
        435                 440                 445             


Asp Asn Leu Lys Lys His Phe Phe Ser Gln Leu Ser Asp Glu Glu Asn 
    450                 455                 460                 


Thr Asp Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Phe Leu Thr Gln 
465                 470                 475                 480 


Ala Asp Asn Ser Pro Ala Asn Asn Ile Pro Ile Tyr Leu Glu Leu Lys 
                485                 490                 495     


Asn Gln Gln Ile Ile Lys Glu Lys Asp Asp Ile Lys Ala Glu Val Asn 
            500                 505                 510         


Asn Ser Gln Asn Arg Asn Pro Asn Lys Pro Ser Lys Arg Asp Leu Leu 
        515                 520                 525             


Asn Lys Ile Ser Asn Thr Asn Glu Asp Phe Tyr Gln Gly Asp Pro Thr 
    530                 535                 540                 


Ala Ile Leu Ser Leu Asn Glu Ile Pro Ala Leu Leu His Leu Phe Leu 
545                 550                 555                 560 


Val Gln Pro Asp Asn Lys Thr Gly Gln Gln Ile Glu Asn Ile Ile Arg 
                565                 570                 575     


Ile Lys Ile Glu Lys Gln Phe Asn Ser Ile Lys Asn Pro Ser Lys Asp 
            580                 585                 590         


Asp Lys Gly Val Pro Lys Ser Leu Phe Ala Asp Thr Asn Val Arg Val 
        595                 600                 605             


Asn Ala Ile Lys Leu Lys Lys Asp Leu Gly Glu Glu Leu Asp Met Leu 
    610                 615                 620                 


Asn Lys Lys Gln Ile Val Phe Lys Glu Asn Gln Lys Ala Ser Ser Asn 
625                 630                 635                 640 


Tyr Asp Glu Leu Leu Lys Lys His Gln Phe Thr Pro Lys Asn Lys Arg 
                645                 650                 655     


Pro Ala Leu Arg Lys Tyr Val Phe Tyr Asn Ser Glu Lys Gly Glu Glu 
            660                 665                 670         


Ala Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Lys Gly Phe 
        675                 680                 685             


Lys Thr Lys Trp Lys Gly Tyr Gln His Ser Glu Leu Gln Arg Lys Leu 
    690                 695                 700                 


Ala Phe Tyr Asp Arg His Thr Lys Gln Asp Ile Lys Glu Leu Leu Ser 
705                 710                 715                 720 


Gly Cys Glu Phe Asp His Phe Leu Leu Asp Ile Asn Ala Cys Phe Lys 
                725                 730                 735     


Glu Asp Asp Phe Glu Asp Phe Phe Ser Lys Tyr Leu Lys Asn Arg Ile 
            740                 745                 750         


Glu Thr Leu Asn Ile Ile Leu Lys Gln Leu His Asp Phe Lys Asn Glu 
        755                 760                 765             


Pro Thr Pro Leu Lys Gly Val Phe Lys Asn Cys Leu Lys Phe Leu Lys 
    770                 775                 780                 


Gln Lys Asn Tyr Val Thr Glu Asn Pro Glu Ile Ile Lys Lys Arg Ile 
785                 790                 795                 800 


Leu Ala Lys Pro Ala Phe Leu Pro Arg Gly Ile Phe Asp Glu Arg Pro 
                805                 810                 815     


Thr Met Lys Lys Gly Lys Asn Pro Leu Ile Asp Arg Asp Glu Phe Ala 
            820                 825                 830         


Lys Trp Phe Val Glu Tyr Leu Glu Asn Lys Asp Tyr Gln Lys Phe Tyr 
        835                 840                 845             


Asn Ser Glu Glu Tyr Arg Ile Arg Asp Ala Asp Phe Lys Lys Asn Ala 
    850                 855                 860                 


Val Ile Lys Lys Gln Lys Leu Lys Asp Phe Tyr Thr Leu Gln Met Val 
865                 870                 875                 880 


Asn Tyr Leu Leu Lys Glu Val Phe Gly Lys Asp Glu Met Asn Leu Gln 
                885                 890                 895     


Leu Ser Glu Leu Phe Gln Thr Arg Gln Glu Arg Leu Lys Leu Gln Gly 
            900                 905                 910         


Ile Ala Lys Lys Gln Met Asn Lys Glu Thr Gly Asp Ser Ser Glu Asn 
        915                 920                 925             


Thr Arg Asn Gln Thr Tyr Ile Trp Asn Lys Asp Val Pro Val Ser Phe 
    930                 935                 940                 


Phe Asn Gly Lys Val Thr Ile Asp Lys Val Lys Leu Lys Asn Ile Gly 
945                 950                 955                 960 


Lys Tyr Lys Arg Tyr Glu Arg Asp Glu Arg Val Lys Thr Phe Ile Gly 
                965                 970                 975     


Tyr Glu Val Asp Glu Lys Trp Met Met Tyr Leu Pro His Asn Trp Lys 
            980                 985                 990         


Asp Arg Tyr Ser Val Lys Pro Ile  Asn Val Ile Asp Leu  Gln Ile Gln 
        995                 1000                 1005             


Glu Tyr  Glu Glu Ile Arg Ser  His Glu Leu Leu Lys  Glu Ile Gln 
    1010                 1015                 1020             


Asn Leu  Glu Gln Tyr Ile Tyr  Asp His Thr Thr Asp  Lys Asn Thr 
    1025                 1030                 1035             


Leu Leu  Gln Asp Gly Asn Pro  Asn Phe Lys Met Tyr  Val Leu Asn 
    1040                 1045                 1050             


Gly Leu  Leu Thr Gly Ile Lys  Gln Val Asn Ile Ala  Asp Phe Ile 
    1055                 1060                 1065             


Val Leu  Lys Gln Asn Thr Asn  Phe Asp Lys Ile Asp  Phe Thr Gly 
    1070                 1075                 1080             


Ile Ala  Ser Cys Ser Glu Leu  Glu Lys Lys Thr Ile  Ile Leu Ile 
    1085                 1090                 1095             


Ala Ile  Arg Asn Lys Phe Ala  His Asn Gln Leu Pro  Asn Lys Thr 
    1100                 1105                 1110             


Ile Tyr  Asp Leu Ala Asn Glu  Phe Leu Lys Lys Glu  Lys Arg Glu 
    1115                 1120                 1125             


Thr Tyr  Ala Asn Tyr Tyr Leu  Lys Val Leu Lys Lys  Met Ile Ser 
    1130                 1135                 1140             


Asp Leu  Ala 
    1145     


<210>  1931
<211>  1098
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1931

Met Glu Thr Thr Thr Val Ala Glu Phe Ser Lys Thr Arg Thr Met Glu 
1               5                   10                  15      


Ser Asp Pro Gln Tyr Phe Gly Ser Tyr Leu Asn Met Ala Arg His Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn Tyr Ile Ala Asp Tyr Phe Asn Leu Ser Arg 
        35                  40                  45              


Leu Lys Asp Asp Asp Leu Ile Gln Asn Ser Phe Leu Cys Asn Pro Asp 
    50                  55                  60                  


Ile Gln Lys Ile Asn Trp Pro Tyr Val Phe Gly Arg Thr Lys His Leu 
65                  70                  75                  80  


Leu Ser Ile Leu Lys Val Phe Asp Thr Asp Thr Leu Pro Lys Asp Glu 
                85                  90                  95      


Val Leu Ser Ser Ser Gln Ala Gly Lys Gln Phe Leu Leu Met Asn Glu 
            100                 105                 110         


Thr Leu Lys Leu Val Phe Arg Glu Leu Gln Gln Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Ala Glu Lys Gly Ser Asp Lys Lys Ile Ile Ile 
    130                 135                 140                 


Asp Glu Gln Leu Val Gln Phe Leu Asn Leu Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ser Tyr Thr Arg Glu Arg Phe Lys Asp Val Phe Ser Glu Asp Asp Phe 
                165                 170                 175     


Lys Tyr Ala Ile Asn Leu Lys Leu Val Lys Glu Asp Asn Lys Ile Thr 
            180                 185                 190         


Val His Gly Met Val Phe Leu Ile Ala Met Phe Leu Glu Arg Glu Glu 
        195                 200                 205             


Ala Phe Ser Phe Ile Ser Arg Ile Ser Gly Leu Lys Gly Thr Tyr Ser 
    210                 215                 220                 


Lys Ser Phe Leu Ala Thr Arg Glu Val Leu Met Ala Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Lys Ser Asn Asp Glu Lys Gln Ala Thr Ser 
                245                 250                 255     


Leu Asp Leu Ile Asn Glu Leu Asn Arg Cys Pro Leu Asp Leu Trp Asn 
            260                 265                 270         


Asn Leu Asn Gln Ser Asp Lys Met Lys Phe Ile Pro Asp Leu Glu Val 
        275                 280                 285             


Asp Glu Asn Gly Asp His Leu Ala Glu Glu Tyr Glu Ile Tyr Ala Glu 
    290                 295                 300                 


Thr Ile Thr Lys Gln Ile Arg Tyr Lys Asn Arg Phe Thr Glu Phe Ala 
305                 310                 315                 320 


Leu Lys Tyr Ile Asp Tyr Ala Gly Val Leu Pro Lys Tyr Lys Met Leu 
                325                 330                 335     


Ile Asp Val Gly Lys Ile Ser Leu Gly Ser Tyr Thr Lys Ile Met Asn 
            340                 345                 350         


Asn Glu Pro Tyr Glu Arg Glu Ile Gln Asp Glu Val Ile Ala Phe Asp 
        355                 360                 365             


Lys Thr Val Glu Tyr Thr Lys Lys Asp Glu Val Leu Lys Arg Val Asp 
    370                 375                 380                 


Ala Glu Lys Arg Thr Lys Gly Phe Thr Arg Phe Asn Pro His Tyr Ser 
385                 390                 395                 400 


Ser Ala Ala Asn Lys Ile Gly Leu Leu Tyr Lys Ser Asp Phe Ser Gln 
                405                 410                 415     


Val Met Pro Ala Gln Asp Arg Lys Leu Gly Ile Arg Leu Asn His Pro 
            420                 425                 430         


Ala Ala Arg Ala Phe Leu Ser Ala Asn Glu Leu Thr Lys Val Ile Leu 
        435                 440                 445             


Leu Asp Tyr Leu Ile Pro Arg Glu Pro Glu Arg Ile Ile Asn Arg Phe 
    450                 455                 460                 


Ile Gln Lys Asn Lys Gln Ile Leu Asp Leu Asn Phe Ile Asn Gln Ile 
465                 470                 475                 480 


Lys Glu Gln Ile Gly Phe Asn Glu Phe Ala Arg Arg Thr Ser Lys Lys 
                485                 490                 495     


Asn Glu His Ala Tyr Thr Glu Gly Ala Leu Asn His Leu Thr Phe Arg 
            500                 505                 510         


Lys Asn Gln Leu Gln Ala Ile Leu Ser Lys Tyr Asn Leu Thr Ile Ala 
        515                 520                 525             


Gln Ile Pro Ser Lys Ile Ile Asp Tyr Trp Leu Asn Ile Lys Pro Val 
    530                 535                 540                 


Asp Glu Tyr Arg Lys Ala Ala Glu Arg Ile Thr Arg Ile Arg Leu Glu 
545                 550                 555                 560 


Thr Lys Thr Arg Tyr Lys Glu His Leu Lys Ala Arg Ile Ala Asn Lys 
                565                 570                 575     


Pro Ala Leu Lys Gln Gly Ile Met Ala Ser Tyr Leu Ala Arg Asp Ile 
            580                 585                 590         


Ile His Met Ile Ile Ser Lys Glu Lys Lys Lys Lys Ile Thr Ser Phe 
        595                 600                 605             


Tyr Tyr Asn Lys Leu Gln Glu Ser Leu Ala Leu Tyr Gly Asn Pro Gly 
    610                 615                 620                 


Met Lys Glu Leu Phe Leu Ser Ile Val Lys Asp Glu Leu Lys Leu Lys 
625                 630                 635                 640 


Ala Ala Asp Gly His Pro Phe Leu Phe Lys Leu Asp Phe Asp Lys Ile 
                645                 650                 655     


Asn Leu Thr Gly Asp Phe Tyr Glu Asn Tyr Leu Trp Glu Lys Ala Val 
            660                 665                 670         


Arg Glu Glu Pro Phe Thr Thr Lys Ser Gly Lys Thr Val Met Lys Asn 
        675                 680                 685             


Thr Ser Trp Ile Thr Arg Thr Phe Tyr Gln Glu Glu Trp Ser Glu Lys 
    690                 695                 700                 


Ala Arg Lys Lys Ile Thr Thr Ile Gln Leu Pro Glu Asn Gln Asp Leu 
705                 710                 715                 720 


Val Pro Val Asn Leu Arg Ile Asn Val Lys Ser Thr Leu Glu Glu Trp 
                725                 730                 735     


Leu Glu Asn Lys Arg Asp Lys Pro Val Asp Leu Pro Thr Asp Leu Phe 
            740                 745                 750         


Asp Glu Ala Ile Leu Gln Asn Leu Ser Ser Leu Thr Glu Ser Ser Ile 
        755                 760                 765             


Thr Ser Thr Gly Lys Lys Leu Asn Trp Asn Glu Leu Phe Lys Ile Trp 
    770                 775                 780                 


Trp Asn Ser Asn His Gln Asp Asp Val Gln Glu Phe Tyr Tyr Tyr Asp 
785                 790                 795                 800 


Arg Glu Tyr Gln Ile Tyr Asp Thr Lys Val Cys Phe Thr Pro Gly Ser 
                805                 810                 815     


Ala Asp Lys Tyr Ser Thr Tyr Tyr Gln Asp Val Phe Asp Arg Leu Phe 
            820                 825                 830         


Asp Gln Lys Thr Ala Leu Arg Lys Ile Glu Lys Arg Arg Asp Pro Lys 
        835                 840                 845             


Leu Ala Asn Val Asp Arg Lys Gln Leu Glu Arg Val Phe Lys Lys Ser 
    850                 855                 860                 


Ile Ala Gly Asn Glu Lys Glu Leu Arg Ile Ile Arg Glu Gln Asp Met 
865                 870                 875                 880 


Val Cys Ala Leu Met Leu Glu Lys Ile Leu Asn Ile Pro Ile Lys Leu 
                885                 890                 895     


Ser Ser Val Asn Ser Trp Leu Ser Gly Ile Ser Lys Ile Glu Gln Thr 
            900                 905                 910         


Ile Thr Val Glu Leu Arg Asn Thr Asn Ser Asp Asn Ala Leu Ala Gly 
        915                 920                 925             


Lys Asp Thr Ile Thr Lys Lys Ile Phe Thr Glu Ala Lys Gly Lys Asp 
    930                 935                 940                 


Tyr Thr Ile Leu His Arg Phe Leu His Asp Lys Arg Leu Pro Glu Leu 
945                 950                 955                 960 


Phe Glu Tyr Phe Thr Glu Asp Glu Ile Asn Leu Glu Arg Leu Arg Glu 
                965                 970                 975     


Glu Ile Lys Ser Tyr Asn Lys His Lys Gln Glu Ile Gln Asp Ala Ala 
            980                 985                 990         


Phe Ser Leu Glu Lys Cys Leu Ile  Glu Leu His Tyr Asp  Glu Ile Thr 
        995                 1000                 1005             


Asp Leu  Phe Ile Asp Ser Glu  Gly Asn Lys Lys Lys  Ser Ser Ile 
    1010                 1015                 1020             


Gln His  Lys Pro Tyr Leu Gln  Trp Leu Leu Asn Lys  Lys Leu Ile 
    1025                 1030                 1035             


Ser Val  Lys Glu Tyr Asp Phe  Leu Leu Met Val Arg  Asn Cys Phe 
    1040                 1045                 1050             


Phe His  Asn Gln Phe Pro Gln  Arg Glu Thr Met Glu  Leu Leu Ile 
    1055                 1060                 1065             


Asp Lys  Trp Cys Tyr Lys Ser  Phe Ala Ala Thr Ile  Ala Glu Val 
    1070                 1075                 1080             


Tyr Thr  Thr Ile Ile Asn Gln  Leu Ile Glu His Ile  Ile Phe Lys 
    1085                 1090                 1095             


<210>  1932
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1932

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Ala Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Asn Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1933
<211>  1277
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1933

Met Ser Tyr Gln Asn Arg Asp Asn Leu Lys Lys Ser Lys Ala Pro Phe 
1               5                   10                  15      


Ser Ile Asp Thr Val Gly Lys Ala Pro Ile Gly Ala Tyr Phe Asn Leu 
            20                  25                  30          


Ala Arg Tyr Asn Phe Tyr Arg Thr Ile Val Asp Ile Tyr Asn Lys Val 
        35                  40                  45              


Gly Phe Ala Val Asn Phe Asp Glu Glu Lys Phe Ala Lys Ala Leu Phe 
    50                  55                  60                  


Ala Leu Tyr Arg Val Thr Ile Gly Lys Lys Asn Glu Met Pro Gln Asn 
65                  70                  75                  80  


Gln Lys Asp Leu Val Asn Gly Ile Lys Leu Thr Thr Asp Lys Gln Glu 
                85                  90                  95      


Lys Leu Lys Arg Leu Leu Tyr Lys His Phe Pro Phe Ile Asp Pro Ile 
            100                 105                 110         


Leu Ala Gly Glu Val Asn Arg Pro Lys Ser Lys Lys Ser Asn Val Ala 
        115                 120                 125             


Asn Asp Glu Glu Gln Met Ala Gly Val Thr Leu Ser Gln Val Leu Lys 
    130                 135                 140                 


Val Val Ala Asn Met Ala Leu Thr Val His Asp Cys Arg Asn Tyr Tyr 
145                 150                 155                 160 


Thr His Tyr Asn Pro Tyr Asn Ser Glu Glu Asp Gln Met Tyr Gln Tyr 
                165                 170                 175     


Trp Arg Gln Gly Leu Val Ala His Tyr Leu Glu Arg Leu Phe Thr Ala 
            180                 185                 190         


Ala Arg Arg Ile Ser Lys Asn Arg Glu Arg Leu Thr Ser Val Glu Met 
        195                 200                 205             


Glu Phe Leu Thr Ser Leu Asn His Tyr Phe Lys Gln Arg Asn Glu Lys 
    210                 215                 220                 


Thr Gly Lys Phe Asp Ile Pro Val Glu Arg Asp Asp Tyr Tyr Phe Lys 
225                 230                 235                 240 


Ile Thr Gly Lys Arg Gln Val Val Asp Ala Ala Gly His Asp Val Glu 
                245                 250                 255     


Val Glu Asp Glu Glu Gly Asn Pro Ile Thr Phe Asn Lys Ala Leu Ser 
            260                 265                 270         


Asp Phe Gly Val Leu Tyr Leu Cys Ile Leu Phe Leu Asn Lys Thr Tyr 
        275                 280                 285             


Ala Arg Lys Leu Ile Asp Glu Met His Leu Leu Asp Gly Lys Arg Val 
    290                 295                 300                 


Gln Ile Gly Lys Ala Ile Arg Asn Lys Glu Thr Gly Arg Trp Glu Thr 
305                 310                 315                 320 


Phe Asp Ile Tyr Glu Gly Cys Pro Tyr Cys Thr Asp Lys Glu Lys Lys 
                325                 330                 335     


Ile Ile Ser Glu Ile Leu Ser Val Tyr Arg Ile Arg Val Pro His Gly 
            340                 345                 350         


Lys Arg Ile Asp Cys Asn Asp Arg Gly Met Gln Leu Ala Met Asp Ile 
        355                 360                 365             


Leu Asn Glu Leu Arg Lys Cys Pro Met Pro Leu Tyr Asp Leu Leu Thr 
    370                 375                 380                 


Pro Glu Gly Arg Arg Thr Phe Glu Asp Glu Val Gln Ala Arg Ser Gly 
385                 390                 395                 400 


Gln Val Asp Asp Lys Gly Asp Pro Ile Tyr Val Pro Thr Gly Asp Val 
                405                 410                 415     


Val Lys Arg Leu Arg His Asp Asp Arg Phe Ala His Leu Val Leu Lys 
            420                 425                 430         


Tyr Ile Asp Glu Lys Gln Leu Phe Ser Arg Ile Arg Phe Gln Val Arg 
        435                 440                 445             


Leu Gly Ala Tyr Arg Phe Lys Phe Tyr Asp Lys Thr Cys Val Asp Gly 
    450                 455                 460                 


Glu Thr Arg Leu Arg Arg Leu Gln Lys Asp Val Asn Gly Tyr Gly Arg 
465                 470                 475                 480 


Leu Gln Glu Ile Glu Ala Leu Lys Gln Glu Glu Tyr Lys Asp Met Leu 
                485                 490                 495     


Gln Gln Thr Gln Asp Val Asp Thr Val Leu Glu Asp Arg Glu Thr Thr 
            500                 505                 510         


Leu Asn Leu Glu Gln Phe Val Glu Asp Asp Ile Asn Ser Gln Pro Tyr 
        515                 520                 525             


Leu Thr Asp Ser Arg Ala Val Tyr Asn Ile His Asn Asn Arg Ile Gly 
    530                 535                 540                 


Met Leu Trp Asn Asp Glu Arg Asn Lys Gly Ala Met Lys Pro Asn Asn 
545                 550                 555                 560 


Gly Asn Pro Tyr Phe Leu Pro Asn Phe Ala Asp Gly Lys Gln Gly Val 
                565                 570                 575     


Val Gln Pro Gly Pro Leu Ala Ser Leu Ser Ile Tyr Asp Phe Pro Ala 
            580                 585                 590         


Met Val Leu Tyr Asp Ile Leu Arg Arg Pro Leu Glu Lys Asn Pro Asp 
        595                 600                 605             


Phe Pro Thr Thr Glu Gln Val Ile Ile Asp Lys His Asp Ala Leu Arg 
    610                 615                 620                 


Arg Phe Phe Asn Asp Val Tyr Ser Glu Asp Ile Phe Asp Arg Asp Thr 
625                 630                 635                 640 


Ala Gly Arg Val Val Leu Phe Ala Asn Glu Gln Ala Leu Ser Gln Arg 
                645                 650                 655     


Ile Gly Glu Arg Tyr Gly Leu Gln Leu Asn Glu Ile Pro Asp Lys Leu 
            660                 665                 670         


Lys Asp Gln Leu Val Lys Thr Arg Lys Pro Gln Glu Ser Gly His Gln 
        675                 680                 685             


Arg Met Leu Arg Leu Val Arg Ala Asp Leu Ser Asp Arg Ile Ser Gln 
    690                 695                 700                 


Val Glu Arg Lys Leu Glu Arg Tyr Arg Asp Thr Leu Arg Ala Val Gly 
705                 710                 715                 720 


Ser Ala Asp Asn Lys Tyr Gly Lys Lys Gln Tyr Val Asp Val Arg His 
                725                 730                 735     


Gly Thr Leu Ala Arg Arg Leu Ala Gly Ser Leu Ala Arg Trp Met Pro 
            740                 745                 750         


Arg Gly Ala Asp Gly Lys Thr Arg Leu Thr Gly Leu Asn Phe Asn Val 
        755                 760                 765             


Leu Thr Ser Thr Leu Ala Thr Phe Gly Ser Gly Thr Ser Tyr Gln Glu 
    770                 775                 780                 


Phe Tyr Glu Met Leu Glu Gln Ala Gly Leu Leu Ser Gly Asp His Ala 
785                 790                 795                 800 


His Pro Phe Leu Arg Arg Val Leu Glu Arg Gly Val Arg Asn Ile Glu 
                805                 810                 815     


Asp Leu Tyr Glu Lys Tyr Met Val Val Glu Ile Glu His Leu Asn Asn 
            820                 825                 830         


Val Leu Lys Asn Asn Asn Leu Gln Ser Leu Pro Phe Val His Pro Gln 
        835                 840                 845             


Arg Ala Arg Trp Ser Asp Arg Asn Tyr Lys Gln Leu Ala His Thr Tyr 
    850                 855                 860                 


Leu His Leu Thr Asp Asp Arg Asp Ala Thr Met Leu Leu Pro Asp Gly 
865                 870                 875                 880 


Leu Phe Ala Pro Trp Leu Lys Arg Ile Met Gln Phe Leu Phe Ala Asp 
                885                 890                 895     


Asn Gln Asp Val Met Asp Ala Leu Ser Asn Asp Gln Ala Cys Asn Ser 
            900                 905                 910         


Ala Ser Tyr Leu Ile Asn Ala Tyr Met Val Tyr Val Gln Glu Asp Glu 
        915                 920                 925             


Ala Gln Pro Phe Tyr Tyr Gly Ser Glu Gln Gln Pro Asp Ala Ile Phe 
    930                 935                 940                 


Asn Arg Ala Tyr Asp Leu Phe Thr Ile Leu Gln Asn Arg Arg Thr Arg 
945                 950                 955                 960 


Glu Arg Ser Tyr Val Pro Ala Tyr Leu Pro Glu Gly Glu Ile Met Asp 
                965                 970                 975     


Arg Leu Lys Glu Lys Thr Thr Asp Gly Lys Arg Lys Ile Met Ala Asp 
            980                 985                 990         


Ile Glu Ala Arg Ala Ser Lys Leu  Asp Lys Thr Asp Leu  Ala Pro Tyr 
        995                 1000                 1005             


Lys Lys  Pro Lys Asn Gly Leu  Ser Pro Arg Gln Gln  Ala Arg Glu 
    1010                 1015                 1020             


Ala Met  Ile Thr Lys Leu Lys  Arg Cys Tyr Lys Glu  Cys Gln Asn 
    1025                 1030                 1035             


Thr Glu  Arg Thr Ile Arg Arg  Tyr Met Thr Gln Asp  Ile Ile Leu 
    1040                 1045                 1050             


Phe Gln  Ile Ala Arg Glu Ile  Leu Ser Glu Met Ile  Asn Phe Gly 
    1055                 1060                 1065             


Asp Pro  Arg Asp Ser Ser Phe  Lys Leu Phe Asn Ile  Phe Glu Pro 
    1070                 1075                 1080             


Asn Phe  Leu Ser His Gly Val  Arg Val Glu Phe Lys  Val Glu Val 
    1085                 1090                 1095             


Phe Gln  Gly Lys Asn Lys Pro  Pro Arg Val Val Thr  Ile Tyr His 
    1100                 1105                 1110             


Asp Asn  Met Ala Leu Lys Asn  Tyr Gly Glu Ile Ser  Arg Leu Val 
    1115                 1120                 1125             


Asn Asp  Glu Arg Thr Leu Ser  Leu Leu Gln Gln Leu  Lys Asp Val 
    1130                 1135                 1140             


Asn Gln  Val Glu Tyr Thr Asp  Leu Cys Gly Glu Phe  Asp Phe Tyr 
    1145                 1150                 1155             


Asp Asn  Arg Arg Thr Ala Val  Phe Lys Ile Val Gln  Glu Ile Glu 
    1160                 1165                 1170             


Gln Leu  Ala Tyr Glu Arg Asn  Arg Leu Thr Leu Asn  Asp Val Asn 
    1175                 1180                 1185             


His Pro  Ala Phe Tyr Val Asp  Gly Asp Ser Ser Asn  Gln Ala Val 
    1190                 1195                 1200             


Arg Thr  Asn Phe Lys Ala Leu  Leu Asp Leu Leu Ser  Gln Glu Val 
    1205                 1210                 1215             


Thr Thr  Leu Ser Ala Asp Asp  Arg Asp Val Leu Arg  Gln Val Arg 
    1220                 1225                 1230             


Asn Ala  Phe Ser His Asn Ser  Tyr Asn Val Ala Leu  Glu Lys Leu 
    1235                 1240                 1245             


Gly Pro  Asn Ala Gln Ile Gln  Leu Pro Arg Val Ala  Lys Leu Ile 
    1250                 1255                 1260             


Ile Asp  His Ile Thr Thr Ile  Gln Ser Ser Ile Pro  Gln Glu 
    1265                 1270                 1275         


<210>  1934
<211>  1277
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1934

Met Ser Tyr Gln Asn Arg Asp Asn Leu Lys Lys Ser Lys Ala Pro Phe 
1               5                   10                  15      


Ser Ile Asp Thr Val Gly Lys Ala Pro Ile Gly Ala Tyr Phe Asn Leu 
            20                  25                  30          


Ala Arg Tyr Asn Phe Tyr Arg Thr Ile Val Asp Ile Tyr Asn Lys Val 
        35                  40                  45              


Gly Phe Ala Val Asn Phe Asp Glu Glu Lys Phe Ala Lys Ala Leu Phe 
    50                  55                  60                  


Ala Leu Tyr Arg Val Thr Ile Gly Lys Lys Asn Glu Met Pro Gln Asn 
65                  70                  75                  80  


Gln Lys Asp Leu Val Asn Gly Ile Lys Leu Thr Thr Asp Lys Gln Glu 
                85                  90                  95      


Lys Leu Lys Arg Leu Leu Tyr Lys His Phe Pro Phe Ile Asp Pro Ile 
            100                 105                 110         


Leu Ala Gly Glu Val Asn Arg Pro Lys Ser Lys Lys Ser Asn Val Ala 
        115                 120                 125             


Asn Asp Glu Glu Gln Met Ala Gly Val Thr Leu Ser Gln Val Leu Lys 
    130                 135                 140                 


Val Val Ala Asn Met Ala Leu Thr Val His Asp Cys Arg Asn Tyr Tyr 
145                 150                 155                 160 


Thr His Tyr Asn Pro Tyr Asn Ser Glu Glu Asp Gln Met Tyr Gln Tyr 
                165                 170                 175     


Trp Arg Gln Gly Leu Val Ala His Tyr Leu Glu Arg Leu Phe Thr Ala 
            180                 185                 190         


Ala Arg Arg Ile Ser Lys Asn Arg Glu Arg Leu Thr Ser Val Glu Met 
        195                 200                 205             


Glu Phe Leu Thr Ser Leu Asn His Tyr Phe Lys Gln Arg Asn Glu Lys 
    210                 215                 220                 


Thr Gly Lys Phe Asp Ile Pro Val Glu Arg Asp Asp Tyr Tyr Phe Lys 
225                 230                 235                 240 


Ile Thr Gly Lys Arg Gln Val Val Asp Ala Ala Gly His Asp Val Glu 
                245                 250                 255     


Val Glu Asp Glu Glu Gly Asn Pro Ile Thr Phe Asn Lys Ala Leu Ser 
            260                 265                 270         


Asp Phe Gly Val Leu Tyr Leu Cys Ile Leu Phe Leu Asn Lys Thr Tyr 
        275                 280                 285             


Ala Arg Lys Leu Ile Asp Glu Met His Leu Leu Asp Gly Lys Arg Val 
    290                 295                 300                 


Gln Ile Gly Lys Ala Ile Arg Asn Lys Glu Thr Gly Arg Trp Glu Thr 
305                 310                 315                 320 


Phe Asp Ile Tyr Glu Gly Cys Pro Tyr Cys Thr Asp Lys Glu Lys Lys 
                325                 330                 335     


Ile Ile Ser Glu Ile Leu Ser Val Tyr Arg Ile Arg Val Pro His Gly 
            340                 345                 350         


Lys Arg Ile Asp Cys Asn Asp Arg Gly Met Gln Leu Ala Met Asp Ile 
        355                 360                 365             


Leu Asn Glu Leu Arg Lys Cys Pro Met Pro Leu Tyr Asp Leu Leu Thr 
    370                 375                 380                 


Pro Glu Gly Arg Arg Thr Phe Glu Asp Glu Val Gln Ala Arg Ser Gly 
385                 390                 395                 400 


Gln Val Asp Asp Lys Gly Asp Pro Ile Tyr Val Pro Thr Gly Asp Val 
                405                 410                 415     


Val Lys Arg Leu Arg His Asp Asp Arg Phe Ala His Leu Val Leu Lys 
            420                 425                 430         


Tyr Ile Asp Glu Lys Gln Leu Phe Ser Arg Ile Arg Phe Gln Val Arg 
        435                 440                 445             


Leu Gly Ala Tyr Arg Phe Lys Phe Tyr Asp Lys Thr Cys Val Asp Gly 
    450                 455                 460                 


Glu Thr Arg Leu Arg Arg Leu Gln Lys Asp Val Asn Gly Tyr Gly Arg 
465                 470                 475                 480 


Leu Gln Glu Ile Glu Ala Leu Lys Gln Glu Glu Tyr Lys Asp Met Leu 
                485                 490                 495     


Gln Gln Thr Gln Asp Val Asp Thr Val Leu Glu Asp Arg Glu Thr Thr 
            500                 505                 510         


Leu Asn Leu Glu Gln Phe Val Glu Asp Asp Ile Asn Ser Gln Pro Tyr 
        515                 520                 525             


Leu Thr Asp Ser Arg Ala Val Tyr Asn Ile His Asn Asn Arg Ile Gly 
    530                 535                 540                 


Met Leu Trp Asn Asp Glu Arg Asn Lys Gly Ala Met Lys Pro Asn Asn 
545                 550                 555                 560 


Gly Asn Pro Tyr Phe Leu Pro Asn Phe Ala Asp Gly Lys Gln Gly Val 
                565                 570                 575     


Val Gln Pro Gly Pro Leu Ala Ser Leu Ser Ile Tyr Asp Phe Pro Ala 
            580                 585                 590         


Met Val Leu Tyr Asp Ile Leu Arg Arg Pro Leu Glu Lys Asn Pro Asp 
        595                 600                 605             


Phe Pro Thr Thr Glu Gln Val Ile Ile Asp Lys His Asp Ala Leu Arg 
    610                 615                 620                 


Arg Phe Phe Asn Asp Val Tyr Ser Glu Asp Ile Phe Asp Arg Asp Thr 
625                 630                 635                 640 


Ala Gly Arg Val Val Leu Phe Ala Asn Glu Gln Ala Leu Ser Gln Arg 
                645                 650                 655     


Ile Gly Glu Arg Tyr Gly Leu Gln Leu Asn Glu Ile Pro Asp Lys Leu 
            660                 665                 670         


Lys Asp Gln Leu Val Lys Thr Arg Lys Pro Gln Glu Ser Gly His Gln 
        675                 680                 685             


Arg Met Leu Arg Leu Val Arg Ala Asp Leu Ser Asp Arg Ile Ser Gln 
    690                 695                 700                 


Val Glu Arg Lys Leu Glu Arg Tyr Arg Asp Thr Leu Arg Ala Val Gly 
705                 710                 715                 720 


Ser Ala Asp Asn Lys Tyr Gly Lys Lys Gln Tyr Val Asp Val Arg His 
                725                 730                 735     


Gly Thr Leu Ala Arg Arg Leu Ala Gly Ser Leu Ala Arg Trp Met Pro 
            740                 745                 750         


Arg Gly Ala Asp Gly Lys Thr Arg Leu Thr Gly Leu Asn Phe Asn Val 
        755                 760                 765             


Leu Thr Ser Thr Leu Ala Thr Phe Gly Ser Gly Thr Ser Tyr Gln Glu 
    770                 775                 780                 


Phe Tyr Glu Met Leu Glu Gln Ala Gly Leu Leu Ser Gly Asp His Ala 
785                 790                 795                 800 


His Pro Phe Leu Arg Arg Val Leu Glu Arg Gly Val Arg Asn Ile Glu 
                805                 810                 815     


Asp Leu Tyr Glu Lys Tyr Met Val Val Glu Ile Glu His Leu Asn Asn 
            820                 825                 830         


Val Leu Lys Asn Asn Asn Leu Gln Ser Leu Pro Phe Val His Pro Gln 
        835                 840                 845             


Arg Ala Arg Trp Ser Asp Arg Asn Tyr Lys Gln Leu Ala His Thr Tyr 
    850                 855                 860                 


Leu His Leu Thr Asp Asp Arg Asp Ala Thr Met Leu Leu Pro Asp Gly 
865                 870                 875                 880 


Leu Phe Ala Pro Trp Leu Lys Arg Ile Met Gln Phe Leu Phe Ala Asp 
                885                 890                 895     


Asn Gln Asp Val Met Asp Ala Leu Ser Asn Asp Gln Ala Cys Asn Ser 
            900                 905                 910         


Ala Ser Tyr Leu Ile Asn Ala Tyr Met Val Tyr Val Gln Glu Asp Glu 
        915                 920                 925             


Ala Gln Pro Phe Tyr Tyr Gly Ser Glu Gln Gln Pro Asp Ala Ile Phe 
    930                 935                 940                 


Asn Arg Ala Tyr Asp Leu Phe Thr Ile Leu Gln Asn Arg Arg Thr Arg 
945                 950                 955                 960 


Glu Arg Ser Tyr Val Pro Ala Tyr Leu Pro Glu Gly Glu Ile Met Asp 
                965                 970                 975     


Arg Leu Lys Glu Lys Thr Thr Asp Gly Lys Arg Lys Ile Met Ala Asp 
            980                 985                 990         


Ile Glu Ala Arg Ala Ser Lys Leu  Asp Lys Thr Asp Leu  Ala Pro Tyr 
        995                 1000                 1005             


Lys Lys  Pro Lys Asn Gly Leu  Ser Pro Arg Gln Gln  Ala Arg Glu 
    1010                 1015                 1020             


Ala Met  Ile Thr Lys Leu Lys  Arg Cys Tyr Lys Glu  Cys Gln Asn 
    1025                 1030                 1035             


Thr Glu  Arg Thr Ile Arg Arg  Tyr Met Thr Gln Asp  Ile Ile Leu 
    1040                 1045                 1050             


Phe Gln  Ile Ala Arg Glu Ile  Leu Ser Glu Met Ile  Asn Phe Gly 
    1055                 1060                 1065             


Asp Pro  Arg Asp Ser Ser Phe  Lys Leu Phe Asn Ile  Phe Glu Pro 
    1070                 1075                 1080             


Asn Phe  Leu Ser His Gly Val  Arg Val Glu Phe Lys  Val Glu Val 
    1085                 1090                 1095             


Phe Gln  Gly Lys Asn Lys Pro  Pro Arg Val Val Thr  Ile Tyr His 
    1100                 1105                 1110             


Asp Asn  Met Ala Leu Lys Asn  Tyr Gly Glu Ile Ser  Arg Leu Val 
    1115                 1120                 1125             


Asn Asp  Glu Arg Thr Leu Ser  Leu Leu Gln Gln Leu  Lys Asp Val 
    1130                 1135                 1140             


Asn Gln  Val Glu Tyr Thr Asp  Leu Cys Gly Glu Phe  Asp Phe Tyr 
    1145                 1150                 1155             


Asp Asn  Arg Arg Thr Ala Val  Phe Lys Ile Val Gln  Glu Ile Glu 
    1160                 1165                 1170             


Gln Leu  Ala Tyr Glu Arg Asn  Arg Leu Thr Leu Asn  Asp Val Asn 
    1175                 1180                 1185             


His Pro  Ala Phe Tyr Val Asp  Gly Asp Ser Ser Asn  Gln Ala Val 
    1190                 1195                 1200             


Arg Thr  Asn Phe Lys Ala Leu  Leu Asp Leu Leu Ser  Gln Glu Val 
    1205                 1210                 1215             


Thr Thr  Leu Ser Ala Asp Asp  Arg Asp Val Leu Arg  Gln Val Arg 
    1220                 1225                 1230             


Asn Ala  Phe Ser His Asn Ser  Tyr Asn Val Ala Leu  Glu Lys Leu 
    1235                 1240                 1245             


Gly Pro  Asn Ala Gln Ile Gln  Leu Pro Arg Val Ala  Lys Leu Ile 
    1250                 1255                 1260             


Ile Asp  His Ile Thr Thr Ile  Gln Ser Ser Ile Pro  Gln Glu 
    1265                 1270                 1275         


<210>  1935
<211>  1277
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1935

Met Ser Tyr Gln Asn Arg Asp Asn Leu Lys Lys Ser Lys Ala Pro Phe 
1               5                   10                  15      


Ser Ile Asp Thr Val Gly Lys Ala Pro Ile Gly Ala Tyr Phe Asn Leu 
            20                  25                  30          


Ala Arg Tyr Asn Phe Tyr Arg Thr Ile Val Asp Ile Tyr Asn Lys Val 
        35                  40                  45              


Gly Phe Ala Val Asn Phe Asp Glu Glu Lys Phe Ala Lys Ala Leu Phe 
    50                  55                  60                  


Ala Leu Tyr Arg Val Thr Ile Gly Lys Lys Asn Glu Met Pro Gln Asn 
65                  70                  75                  80  


Gln Lys Asp Leu Val Asn Gly Ile Lys Leu Thr Thr Asp Lys Gln Glu 
                85                  90                  95      


Lys Leu Lys Arg Leu Leu Tyr Lys His Phe Pro Phe Ile Asp Pro Ile 
            100                 105                 110         


Leu Ala Gly Glu Val Asn Arg Pro Lys Ser Lys Lys Ser Asn Val Ala 
        115                 120                 125             


Asn Asp Glu Glu Gln Met Ala Gly Val Thr Leu Ser Gln Val Leu Lys 
    130                 135                 140                 


Val Val Ala Asn Met Ala Leu Thr Val His Asp Cys Arg Asn Tyr Tyr 
145                 150                 155                 160 


Thr His Tyr Asn Pro Tyr Asn Ser Glu Glu Asp Gln Met Tyr Gln Tyr 
                165                 170                 175     


Trp Arg Gln Gly Leu Val Ala His Tyr Leu Glu Arg Leu Phe Thr Ala 
            180                 185                 190         


Ala Arg Arg Ile Ser Lys Asn Arg Glu Arg Leu Thr Ser Val Glu Met 
        195                 200                 205             


Glu Phe Leu Thr Ser Leu Asn His Tyr Phe Lys Gln Arg Asn Glu Lys 
    210                 215                 220                 


Thr Gly Lys Phe Asp Ile Pro Val Glu Arg Asp Asp Tyr Tyr Phe Lys 
225                 230                 235                 240 


Ile Thr Gly Lys Arg Gln Val Val Asp Ala Ala Gly His Asp Val Glu 
                245                 250                 255     


Val Glu Asp Glu Glu Gly Asn Pro Ile Thr Phe Asn Lys Ala Leu Ser 
            260                 265                 270         


Asp Phe Gly Val Leu Tyr Leu Cys Ile Leu Phe Leu Asn Lys Thr Tyr 
        275                 280                 285             


Ala Arg Lys Leu Ile Asp Glu Met His Leu Leu Asp Gly Lys Arg Val 
    290                 295                 300                 


Gln Ile Gly Lys Ala Ile Arg Asn Lys Glu Thr Gly Arg Trp Glu Thr 
305                 310                 315                 320 


Phe Asp Ile Tyr Glu Gly Cys Pro Tyr Cys Thr Asp Lys Glu Lys Lys 
                325                 330                 335     


Ile Ile Ser Glu Ile Leu Ser Val Tyr Arg Ile Arg Val Pro His Gly 
            340                 345                 350         


Lys Arg Ile Asp Cys Asn Asp Arg Gly Met Gln Leu Ala Met Asp Ile 
        355                 360                 365             


Leu Asn Glu Leu Arg Lys Cys Pro Met Pro Leu Tyr Asp Leu Leu Thr 
    370                 375                 380                 


Pro Glu Gly Arg Arg Thr Phe Glu Asp Glu Val Gln Ala Arg Ser Gly 
385                 390                 395                 400 


Gln Val Asp Asp Lys Gly Asp Pro Ile Tyr Val Pro Thr Gly Asp Val 
                405                 410                 415     


Val Lys Arg Leu Arg His Asp Asp Arg Phe Ala His Leu Val Leu Lys 
            420                 425                 430         


Tyr Ile Asp Glu Lys Gln Leu Phe Ser Arg Ile Arg Phe Gln Val Arg 
        435                 440                 445             


Leu Gly Ala Tyr Arg Phe Lys Phe Tyr Asp Lys Thr Cys Val Asp Gly 
    450                 455                 460                 


Glu Thr Arg Leu Arg Arg Leu Gln Lys Asp Val Asn Gly Tyr Gly Arg 
465                 470                 475                 480 


Leu Gln Glu Ile Glu Ala Leu Lys Gln Glu Glu Tyr Lys Asp Met Leu 
                485                 490                 495     


Gln Gln Thr Gln Asp Val Asp Thr Val Leu Glu Asp Arg Glu Thr Thr 
            500                 505                 510         


Leu Asn Leu Glu Gln Phe Val Glu Asp Asp Ile Asn Ser Gln Pro Tyr 
        515                 520                 525             


Leu Thr Asp Ser Arg Ala Val Tyr Asn Ile His Asn Asn Arg Ile Gly 
    530                 535                 540                 


Met Leu Trp Asn Asp Glu Arg Asn Lys Gly Ala Met Lys Pro Asn Asn 
545                 550                 555                 560 


Gly Asn Pro Tyr Phe Leu Pro Asn Phe Ala Asp Gly Lys Gln Gly Val 
                565                 570                 575     


Val Gln Pro Gly Pro Leu Ala Ser Leu Ser Ile Tyr Asp Phe Pro Ala 
            580                 585                 590         


Met Val Leu Tyr Asp Ile Leu Arg Arg Pro Leu Glu Lys Asn Pro Asp 
        595                 600                 605             


Phe Pro Thr Thr Glu Gln Val Ile Ile Asp Lys His Asp Ala Leu Arg 
    610                 615                 620                 


Arg Phe Phe Asn Asp Val Tyr Ser Glu Asp Ile Phe Asp Arg Asp Thr 
625                 630                 635                 640 


Ala Gly Arg Val Val Leu Phe Ala Asn Glu Gln Ala Leu Ser Gln Arg 
                645                 650                 655     


Ile Gly Glu Arg Tyr Gly Leu Gln Leu Asn Glu Ile Pro Asp Lys Leu 
            660                 665                 670         


Lys Asp Gln Leu Val Lys Thr Arg Lys Pro Gln Glu Ser Gly His Gln 
        675                 680                 685             


Arg Met Leu Arg Leu Val Arg Ala Asp Leu Ser Asp Arg Ile Ser Gln 
    690                 695                 700                 


Val Glu Arg Lys Leu Glu Arg Tyr Arg Asp Thr Leu Arg Ala Val Gly 
705                 710                 715                 720 


Ser Ala Asp Asn Lys Tyr Gly Lys Lys Gln Tyr Val Asp Val Arg His 
                725                 730                 735     


Gly Thr Leu Ala Arg Arg Leu Ala Gly Ser Leu Ala Arg Trp Met Pro 
            740                 745                 750         


Arg Gly Ala Asp Gly Lys Thr Arg Leu Thr Gly Leu Asn Phe Asn Val 
        755                 760                 765             


Leu Thr Ser Thr Leu Ala Thr Phe Gly Ser Gly Thr Ser Tyr Gln Glu 
    770                 775                 780                 


Phe Tyr Glu Met Leu Glu Gln Ala Gly Leu Leu Ser Gly Asp His Ala 
785                 790                 795                 800 


His Pro Phe Leu Arg Arg Val Leu Glu Arg Gly Val Arg Asn Ile Glu 
                805                 810                 815     


Asp Leu Tyr Glu Lys Tyr Met Val Val Glu Ile Glu His Leu Asn Asn 
            820                 825                 830         


Val Leu Lys Asn Asn Asn Leu Gln Ser Leu Pro Phe Val His Pro Gln 
        835                 840                 845             


Arg Ala Arg Trp Ser Asp Arg Asn Tyr Lys Gln Leu Ala His Thr Tyr 
    850                 855                 860                 


Leu His Leu Thr Asp Asp Arg Asp Ala Thr Met Leu Leu Pro Asp Gly 
865                 870                 875                 880 


Leu Phe Ala Pro Trp Leu Lys Arg Ile Met Gln Phe Leu Phe Ala Asp 
                885                 890                 895     


Asn Gln Asp Val Met Asp Ala Leu Ser Asn Asp Gln Ala Cys Asn Ser 
            900                 905                 910         


Ala Ser Tyr Leu Ile Asn Ala Tyr Met Val Tyr Val Gln Glu Asp Glu 
        915                 920                 925             


Ala Gln Pro Phe Tyr Tyr Gly Ser Glu Gln Gln Pro Asp Ala Ile Phe 
    930                 935                 940                 


Asn Arg Ala Tyr Asp Leu Phe Thr Ile Leu Gln Asn Arg Arg Thr Arg 
945                 950                 955                 960 


Glu Arg Ser Tyr Val Pro Ala Tyr Leu Pro Glu Gly Glu Ile Met Asp 
                965                 970                 975     


Arg Leu Lys Glu Lys Thr Thr Asp Gly Lys Arg Lys Ile Met Ala Asp 
            980                 985                 990         


Ile Glu Ala Arg Ala Ser Lys Leu  Asp Lys Thr Asp Leu  Ala Pro Tyr 
        995                 1000                 1005             


Lys Lys  Pro Lys Asn Gly Leu  Ser Pro Arg Gln Gln  Ala Arg Glu 
    1010                 1015                 1020             


Ala Met  Ile Thr Lys Leu Lys  Arg Cys Tyr Lys Glu  Cys Gln Asn 
    1025                 1030                 1035             


Thr Glu  Arg Thr Ile Arg Arg  Tyr Met Thr Gln Asp  Ile Ile Leu 
    1040                 1045                 1050             


Phe Gln  Ile Ala Arg Glu Ile  Leu Ser Glu Met Ile  Asn Phe Gly 
    1055                 1060                 1065             


Asp Pro  Arg Asp Ser Ser Phe  Lys Leu Phe Asn Ile  Phe Glu Pro 
    1070                 1075                 1080             


Asn Phe  Leu Ser His Gly Val  Arg Val Glu Phe Lys  Val Glu Val 
    1085                 1090                 1095             


Phe Gln  Gly Lys Asn Lys Pro  Pro Arg Val Val Thr  Ile Tyr His 
    1100                 1105                 1110             


Asp Asn  Met Ala Leu Lys Asn  Tyr Gly Glu Ile Ser  Arg Leu Val 
    1115                 1120                 1125             


Asn Asp  Glu Arg Thr Leu Ser  Leu Leu Gln Gln Leu  Lys Asp Val 
    1130                 1135                 1140             


Asn Gln  Val Glu Tyr Thr Asp  Leu Cys Gly Glu Phe  Asp Phe Tyr 
    1145                 1150                 1155             


Asp Asn  Arg Arg Thr Ala Val  Phe Lys Ile Val Gln  Glu Ile Glu 
    1160                 1165                 1170             


Gln Leu  Ala Tyr Glu Arg Asn  Arg Leu Thr Leu Asn  Asp Val Asn 
    1175                 1180                 1185             


His Pro  Ala Phe Tyr Val Asp  Gly Asp Ser Ser Asn  Gln Ala Val 
    1190                 1195                 1200             


Arg Thr  Asn Phe Lys Ala Leu  Leu Asp Leu Leu Ser  Gln Glu Val 
    1205                 1210                 1215             


Thr Thr  Leu Ser Ala Asp Asp  Arg Asp Val Leu Arg  Gln Val Arg 
    1220                 1225                 1230             


Asn Ala  Phe Ser His Asn Ser  Tyr Asn Val Ala Leu  Glu Lys Leu 
    1235                 1240                 1245             


Gly Pro  Asn Ala Gln Ile Gln  Leu Pro Arg Val Ala  Lys Leu Ile 
    1250                 1255                 1260             


Ile Asp  His Ile Thr Thr Ile  Gln Ser Ser Ile Pro  Gln Glu 
    1265                 1270                 1275         


<210>  1936
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1936

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Met Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Met Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Val Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1937
<211>  1126
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1937

Met Glu Thr Asn Gln Lys Pro Asn Tyr Lys Lys Phe Thr Asn Glu Gln 
1               5                   10                  15      


Asp Lys Pro Phe Phe Ser Gly Tyr Leu Asn Thr Ala Lys Gln Asn Val 
            20                  25                  30          


Phe Ile Ile Phe Arg Asp Ile Ser Glu Arg Leu Gly Leu Gly Phe Asp 
        35                  40                  45              


Leu Ser Asn Asp Asp Asn Ile Met Asn Ala Asp Leu Trp Glu Tyr Leu 
    50                  55                  60                  


Lys Asn Asn Lys Arg Pro Glu Ile Thr Gln His Ile Ile Glu Lys Leu 
65                  70                  75                  80  


Met Tyr His Phe Pro Phe Ala Ser His Leu Thr Thr Asn Tyr Ala Tyr 
                85                  90                  95      


Tyr Lys Arg Lys Glu Asn Gln Ala Glu Pro Leu Asp Tyr Tyr Glu Ile 
            100                 105                 110         


Phe Glu Leu Leu Ile Lys Gln Leu Tyr Glu Tyr Arg Asn Phe Tyr Thr 
        115                 120                 125             


His Val Val His Asp Pro Val Ile Met Asn Lys Val Ile Ile Asn Gly 
    130                 135                 140                 


Met Arg Ile Leu Phe Asp Ala Ala Arg Ile Glu Val Lys Asp Arg Phe 
145                 150                 155                 160 


Asn Leu Lys Thr Glu Asp Val Asn His Leu Val Arg Leu Gly Pro Lys 
                165                 170                 175     


Gly Lys Glu Asn Lys Asn Phe Tyr Tyr Asn Phe Ser Asp Asp Glu Arg 
            180                 185                 190         


Asn Val Ser Glu Lys Gly Leu Ala Phe Phe Ile Cys Leu Gly Leu Gln 
        195                 200                 205             


Arg Lys Asp Ala Gln Ile Phe Leu Lys Ser Leu Val Gly Phe Lys Leu 
    210                 215                 220                 


Ser Glu Ser Pro Ser Gln Lys Ala Thr Leu Glu Val Tyr Thr Asn Tyr 
225                 230                 235                 240 


Ser Pro Arg Ile Pro Gln Pro Arg Leu Thr Ser Asp Asn Ser Ile Glu 
                245                 250                 255     


Gly Leu Leu Leu Asp Met Val Asn Glu Leu Lys Arg Cys Pro Lys Glu 
            260                 265                 270         


Leu Tyr His Leu Leu Ser Ile Glu Asp Arg Glu Lys Phe Lys Ala Val 
        275                 280                 285             


Lys Glu Asp Asn Thr Tyr Asp Asp Asn Asp Glu Tyr Glu Ala Met Pro 
    290                 295                 300                 


Val Leu Lys Arg Ser Arg Asn Arg Phe Phe Tyr Phe Ala Leu Arg Tyr 
305                 310                 315                 320 


Leu Asp Asn Asn Leu Gln Asn Ile Lys Phe His Ile Asp Leu Gly Asn 
                325                 330                 335     


Tyr Cys Phe His Val Tyr Glu Gln Glu Ile Glu Glu Ile Val Arg Lys 
            340                 345                 350         


Arg Arg Trp Ile Lys Arg Met Thr Ser Phe Gly Asn Leu Glu Asp Phe 
        355                 360                 365             


Ala Asp Lys Met Arg Pro Ala Tyr Trp Val Glu Lys Thr Leu Lys Leu 
    370                 375                 380                 


Glu Asp Lys Lys Val Asp Asn Pro Asn Ile Tyr Ile Thr Asp Thr Thr 
385                 390                 395                 400 


Pro His Tyr His Ile Asn Gly Gln Asn Ile Gly Ile Lys Phe Ile Asn 
                405                 410                 415     


Asn Tyr Val Ala Leu Arg Lys Asn Asn Lys Ile Trp Pro Glu Leu Pro 
            420                 425                 430         


Asp Phe Gly Asp Asn Asn Lys Thr Asn Lys Pro Arg Asn Glu Thr Pro 
        435                 440                 445             


Asp Cys Trp Leu Ser Leu Tyr Glu Leu Pro Ser Ile Val Phe Tyr His 
    450                 455                 460                 


Leu Leu Lys Gln Gln Asn Ile Gly Leu Pro Ser Val Glu Arg Ile Ile 
465                 470                 475                 480 


Asn Asp His Arg Asn Gln Ile Arg Gly Phe Phe Asn Asp Leu Glu Asn 
                485                 490                 495     


Asn Arg Ile Val Pro Ser Phe Thr Asp Thr Thr Leu Lys Ala Glu Leu 
            500                 505                 510         


Lys Asn Arg Gly Leu Lys Lys Ser Gln Ile Pro Ser Ala Ile Val Lys 
        515                 520                 525             


Tyr Leu Thr Ser Lys Pro Val Met Ser Phe Glu Ala Lys Ala Ser Lys 
    530                 535                 540                 


Arg Leu Ser Glu Leu Val Thr Glu Thr Ser Glu Lys Leu Asp Lys Ile 
545                 550                 555                 560 


Lys Arg Gln Glu Gln His Tyr Leu Lys Lys Pro Gly Ser Lys Asp Tyr 
                565                 570                 575     


Ile Asp Met Lys Cys Gly His Leu Ala Asp Phe Leu Ala Arg Asp Met 
            580                 585                 590         


Ile Ser Leu Gln Lys Pro Tyr Asn Asn Met Asp Gly Lys Ala Asn Ser 
        595                 600                 605             


Thr Glu Phe Gln Ile Leu Gln Ser Lys Leu Ala Tyr Phe Gly Lys Asn 
    610                 615                 620                 


Lys Asp Ser Leu Ser Lys Thr Phe His Leu Phe Asn Leu Met Gly Ser 
625                 630                 635                 640 


Gln Asn Ile His Pro Phe Leu Tyr Lys Ile Asp Ile Asn Gln Cys Ile 
                645                 650                 655     


Gly Ile Leu Asp Phe Tyr Lys Lys Tyr Leu Asp His Arg Tyr Ile Tyr 
            660                 665                 670         


Phe Lys Gln Cys Leu Asn Glu Lys Arg Tyr Ser Glu Tyr His Phe Leu 
        675                 680                 685             


Lys Leu Gly Gly Lys Ser Lys Glu Gln Gly Arg Asp Tyr Phe Val Lys 
    690                 695                 700                 


Leu Ala Asn Thr Leu Gln Lys Glu Thr Val Met Asn Leu Pro Arg Gly 
705                 710                 715                 720 


Leu Phe Leu Glu Ser Ile Ile Arg Ile Leu Lys Ala Asn Asp Asn Ser 
                725                 730                 735     


Arg Pro Phe Ala Ile Glu Ile Glu Lys Met Glu Arg Val Asn Ala Ala 
            740                 745                 750         


Tyr Val Ile Asp Gln Tyr Leu Gly Arg Ile Leu Asn Asp Lys Pro Gln 
        755                 760                 765             


Val Phe Tyr Ser Tyr Asn Lys Ser Tyr Glu Phe Leu Asn Lys Leu Phe 
    770                 775                 780                 


Asp Ser Arg Lys Ile Ser Glu Lys Arg Asn Ala Leu Pro Glu Val Tyr 
785                 790                 795                 800 


Phe Asp Thr Gly Glu Leu Ala Lys Lys Thr Thr Ile Ser Val Lys Gly 
                805                 810                 815     


Gln Lys Asp Asn Glu Ile Thr Arg Ser Leu Thr Lys Thr Val Glu Gln 
            820                 825                 830         


His Ile Lys Arg Asn Arg Ile Phe Asp Glu Lys Glu Lys Thr Lys Val 
        835                 840                 845             


Tyr Asp Gln Tyr Met Ala Arg Tyr Asn Asp Phe Thr Glu Asn Glu Lys 
    850                 855                 860                 


Gln Ile Arg Leu Ala Lys Thr Cys Asp Glu Val Met Phe Met Met Ile 
865                 870                 875                 880 


Asp Asp Ile Phe Arg Lys Tyr Phe Val Leu Asp Asn Gly Thr Leu Lys 
                885                 890                 895     


Lys Lys Thr Ile Glu Ala Ile Pro Phe Ile Gln Leu Gly Asp Asp Tyr 
            900                 905                 910         


Lys Leu Gly Ser Ile Lys Pro Asp Ser Glu Lys Gly Phe Leu Ser Leu 
        915                 920                 925             


Gln Thr Thr Val Lys Leu Gln Met Pro Phe Thr Tyr Glu Thr Asn Thr 
    930                 935                 940                 


Asp Lys Val Leu Lys Val Lys Gly Ala Glu Ser Lys Leu Ser Ala Arg 
945                 950                 955                 960 


Tyr Ile Lys Thr Ile Val Arg Glu Thr Ile Lys Ile Lys Asn Tyr Gly 
                965                 970                 975     


Asp Phe Arg Ala Phe Leu Lys Asp Arg Arg Ile Ser Ser Leu Leu Pro 
            980                 985                 990         


Tyr Leu Ser Asp Arg Glu Ile His  Tyr Glu Ala Leu Gln  Lys Glu Leu 
        995                 1000                 1005             


Glu Leu  Phe Gln Lys Ala Arg  Met Glu Val Phe Asp  Arg Ile Phe 
    1010                 1015                 1020             


Arg Phe  Glu Lys Asp Ile Thr  Gly Ala Phe His Ile  Pro Lys Asn 
    1025                 1030                 1035             


Lys Asn  Gly Tyr Ile Tyr His  Thr Glu Ile Leu Lys  Gln Lys Ile 
    1040                 1045                 1050             


Asn Glu  Gly Asp Glu Arg Phe  Gly Phe Ile Lys Glu  Leu Arg Asn 
    1055                 1060                 1065             


Ala Phe  Asn His Ser Asn Tyr  Pro Ala Tyr Val Leu  Phe Lys Asp 
    1070                 1075                 1080             


Phe Ile  Asp Gly Ser Gln Phe  Asn Glu Leu Arg Asn  Tyr Lys Ser 
    1085                 1090                 1095             


Gly Asp  Thr Glu Val Glu Asn  Lys Ser Val Ile Leu  Gln Phe Lys 
    1100                 1105                 1110             


Asn Leu  Leu Ile Gln Tyr Tyr  Asp Glu Leu Thr Asp  Leu 
    1115                 1120                 1125     


<210>  1938
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1938

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Thr 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1939
<211>  1057
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1939

Met Thr Ile Lys Glu Gln Ser His Phe Ala Ala Tyr Tyr Asn Met Ala 
1               5                   10                  15      


Arg His Asn Met Tyr Glu Thr Leu Cys Tyr Ile Ser Lys Ile Ser Gly 
            20                  25                  30          


Ile Gln Glu Gly Glu Asp Asn Lys Glu Ser Lys Ile Glu Asp Met Gln 
        35                  40                  45              


Leu Leu Arg Val Leu Thr Thr Lys Gly His Pro Glu Glu Lys Ile Arg 
    50                  55                  60                  


Ile Glu Lys Leu Ile Tyr Lys His Leu Pro Leu Phe Arg Pro Ala Val 
65                  70                  75                  80  


Glu Asp Leu Arg Lys Lys Ser Lys Glu Asn Val Lys Ser Pro Glu Leu 
                85                  90                  95      


Leu Ala Lys Val Ile Lys Asn Trp Ala Lys Val Ile Thr Tyr Tyr Arg 
            100                 105                 110         


Asp Lys Phe Thr His Tyr Val Phe Ile Asp Lys Arg His Glu Asn Lys 
        115                 120                 125             


Glu Phe Leu Asn Ala Glu Met Ser Val Ala Asn Asp Leu Asn Gln Ile 
    130                 135                 140                 


Phe Thr Ala Ser Ala Arg Val Ile Lys Glu Arg Phe Gly Leu Ser Thr 
145                 150                 155                 160 


Glu Leu Glu Phe Leu Thr Lys Gly Arg Tyr Arg Thr Gln Thr Ile Asp 
                165                 170                 175     


Gly Lys Arg Ser Thr Lys Leu Asn Pro Asn Phe Ile Tyr Ser Leu Gln 
            180                 185                 190         


Asp Lys Asn Glu Arg Leu Asn Lys Met Gly Leu Ile Phe Leu Ala Cys 
        195                 200                 205             


Gln Leu Ile Glu Lys Lys Tyr Ala Ser Met Leu Phe Asp Gln Gln Gly 
    210                 215                 220                 


Tyr Met Gly Arg Asp Ile Tyr Phe Asp Phe Thr Pro Ala Gln Cys Lys 
225                 230                 235                 240 


Tyr Ile Arg Glu Val Phe Ser Ala His Arg Ile Val Leu Pro Arg Gly 
                245                 250                 255     


Arg Met Asp Val Glu Arg Asn Glu Ile Thr Ile Ala Met Asp Met Phe 
            260                 265                 270         


Asn Glu Leu Gly Lys Cys Pro Lys Glu Leu Phe Glu Ile Ile Ser Lys 
        275                 280                 285             


Glu Glu Gln Lys Arg Phe Arg Thr Lys Ser Glu Thr Thr Gly Glu Glu 
    290                 295                 300                 


Val Leu Leu Met Arg His Ser Asp Arg Phe Ala Thr Leu Ala Leu Gln 
305                 310                 315                 320 


Tyr Ile Asp Asn Arg Lys Val Phe Glu Lys Ile Arg Phe Gln Leu Ser 
                325                 330                 335     


Leu Gly Lys Tyr Arg Tyr Lys Phe Tyr Asp Lys Thr Cys Val Asp Gly 
            340                 345                 350         


Asp Thr His Val Arg Ile Leu Gln Lys Glu Leu Asn Gly Phe Gly Arg 
        355                 360                 365             


Ile Asn Glu Ile Glu Leu Leu Lys Glu Glu Lys Trp Gly Gly Leu Ile 
    370                 375                 380                 


Arg Lys Phe Glu Asp Ala Lys Ile Asp Thr Ala Glu Thr Lys Pro Tyr 
385                 390                 395                 400 


Ile Thr Asp Gln Tyr Pro Gln Tyr Leu Phe Asn Gly Asn Arg Ile Gly 
                405                 410                 415     


Ile Tyr Phe Asn Ser Ala His Gly Lys Ala Met Arg Asn Gly Ala Tyr 
            420                 425                 430         


Ile Pro Asp Ile Glu Ser Gly Ala His Cys Ile Gln Pro Ile Cys Trp 
        435                 440                 445             


Ile Ser Asn Tyr Glu Leu Pro Ala Leu Ile Phe His His Ile Leu Thr 
    450                 455                 460                 


Lys Asp Glu Lys Lys Ser Leu Thr Glu Lys Ile Ile Ile Asp Cys Val 
465                 470                 475                 480 


Glu Arg Tyr Lys Lys Leu Phe Asn Asp Ile Ala Glu Gly Lys Val Ala 
                485                 490                 495     


Arg Thr Gly Asn Ala Thr Ser Asp Phe Glu Met Ile Ser Lys Glu Tyr 
            500                 505                 510         


Gly Ile Glu Lys Ser Asp Ile Pro Arg Glu Leu Gln Asp Tyr Phe Asn 
        515                 520                 525             


Gly Thr Glu Arg Asp Gly Ile Glu Gln Tyr Ala Lys Ala Gln Ile Arg 
    530                 535                 540                 


Glu Met Ile Glu Glu Asn Arg Ile Arg Leu Glu Gln Phe Asn Ser Lys 
545                 550                 555                 560 


Leu Lys Lys Ile Glu Asp Gly Glu Val Lys Tyr Gly Lys Arg Asp Tyr 
                565                 570                 575     


Thr Glu Ile Arg Thr Gly Glu Leu Ala Gln Tyr Leu Ala Lys Asp Ile 
            580                 585                 590         


Val Met Phe Met Pro Lys Ala Lys Tyr Lys Pro Thr Ser Lys Asn Tyr 
        595                 600                 605             


Asn Val Met Gln Ala Leu Leu Ala Thr Phe Asn Gly Ser Glu Ser Gly 
    610                 615                 620                 


Ser Thr Leu Asp Glu Val Asp Asp Met Phe Asp Asn Ile Lys Ala Cys 
625                 630                 635                 640 


Tyr Trp Lys Asn Glu Ser Asp Asn His Pro Phe Leu Glu Tyr Val Leu 
                645                 650                 655     


Gly Glu Glu Pro Lys Asp Ile Ile Ala Phe Tyr Lys Ile Tyr Leu Glu 
            660                 665                 670         


Leu Arg Gly Glu Tyr Leu Asp Lys Cys Ile Lys Lys Met Asp Leu Ala 
        675                 680                 685             


Thr Ile Pro Phe Ile His Thr Glu Arg Lys Arg Trp Glu Lys Arg Asp 
    690                 695                 700                 


Glu Lys Phe Phe Lys Glu Leu Ala Gln Arg Tyr Ala Thr Gln Pro Ile 
705                 710                 715                 720 


Glu Leu Pro Arg Gly Leu Tyr Asp Arg Ala Ile Lys Glu Tyr Leu Lys 
                725                 730                 735     


Ser Lys Ser Ile Leu Glu Asp Val Ile Ala Gln Glu Gln Cys Asn Val 
            740                 745                 750         


Thr Tyr Leu Ile Ala Arg Tyr Met Gln Asp Val Leu Lys Asp Asp Ser 
        755                 760                 765             


Gln Gln Phe Tyr Ser Leu Pro Arg His Tyr Ser Cys Leu Ser Glu Lys 
    770                 775                 780                 


Asp Lys Tyr Leu Ser Leu Thr Glu Arg Glu Ala Ile Ala Lys Ser Asp 
785                 790                 795                 800 


Ala Leu Asn Ser Phe Lys Lys Arg Glu Arg Glu Lys Glu Asn Glu Asn 
                805                 810                 815     


Arg Arg Gly Asn Arg Arg Tyr Asn Lys Gly Glu Asn Lys Asn Thr Ile 
            820                 825                 830         


Lys Asp Arg Asp Thr Glu Glu Lys Phe Asn Ser Leu Tyr Arg Lys Met 
        835                 840                 845             


Asp Asn Asn Glu Arg Ile Leu Arg Arg Tyr Lys Val Gln Asp Met Leu 
    850                 855                 860                 


Leu Tyr Leu Leu Ala Cys Asp Ile Ile Lys Gly Ile Met Arg Glu Asp 
865                 870                 875                 880 


Phe Gly Tyr Lys Leu Ser Met Ile Thr Asp Gly Lys Asn Ser Asn Phe 
                885                 890                 895     


Phe Asp Tyr Lys Met Pro Glu Phe Lys Thr Thr Ile Thr Leu Lys Glu 
            900                 905                 910         


Gly Lys Lys Phe Thr Ile Lys Gln Gln Tyr Leu Lys Ile Lys Asn Tyr 
        915                 920                 925             


Gly Asp Phe Leu Lys Phe Ile Phe Asp Leu Arg Ile Asp Ser Leu Leu 
    930                 935                 940                 


Ser Asn Gly Thr Lys Val Glu Ile Asp Arg Asn Ile Leu Glu Asp Glu 
945                 950                 955                 960 


Leu Ser Asn Tyr Asp Gly Ser Arg Pro Lys Val Phe Glu Thr Leu Leu 
                965                 970                 975     


Met Ile Glu Lys Ile Val Val Glu Lys His Lys Glu Leu Lys Asp Leu 
            980                 985                 990         


Glu His Ile Thr Phe Gly Asp Val  Leu Asn Val Ile Lys  Met Glu Glu 
        995                 1000                 1005             


Gly Glu  Lys Lys Ile Leu Arg  Leu Ile Arg Asn Ala  Phe Ser His 
    1010                 1015                 1020             


Asn Tyr  Tyr Pro Thr Ile Lys  Asp Val Asn Tyr Asp  Asn Met Pro 
    1025                 1030                 1035             


Glu Val  Ala Glu Ser Leu Lys  Asp Ile Leu Glu Lys  Glu Ser Lys 
    1040                 1045                 1050             


Lys Leu  Thr Asn 
    1055         


<210>  1940
<211>  1147
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1940

Met Glu Glu Thr Thr Thr Met Gly Lys Gly Val Ala Tyr Asp His Thr 
1               5                   10                  15      


Leu Phe Lys Asp Lys His Tyr Phe Ala Gly Tyr Leu Asn Leu Ala Val 
            20                  25                  30          


Asn Asn Ile Glu Asn Val Phe Lys Thr Val Tyr Lys Asn Arg Phe Asp 
        35                  40                  45              


Ile Lys Gln His Asn Leu Tyr Lys Ile Leu Asp Ser Leu Asp Gly Gln 
    50                  55                  60                  


Ile Ser Glu Pro Asp Tyr Ile Glu Arg Val Ser Phe Leu Lys Gln Tyr 
65                  70                  75                  80  


Phe Pro Val Leu His Tyr Leu Asp Leu His Pro Asp Asn Lys Arg Phe 
                85                  90                  95      


Thr Lys Glu Glu Asp Lys Val Lys Ala Arg Arg Arg Tyr Leu Ile Asn 
            100                 105                 110         


Asn Leu Arg Leu Leu Ile Glu Thr Leu Ser Lys Leu Arg Asp Phe Tyr 
        115                 120                 125             


Thr His Tyr Tyr His Lys Pro Leu Ser Ile Glu Gln Asn Thr Phe Ser 
    130                 135                 140                 


Leu Ile Asp Asn Ile Phe Leu Asn Val Val Ile Asp Val Lys Arg Gln 
145                 150                 155                 160 


Lys Lys Lys Asn Asp His Thr Arg Gln Leu Leu Lys Asp Ser Leu Lys 
                165                 170                 175     


Glu Glu Met Asp Ile Leu Tyr Gln Lys Thr Lys Ala Ser Leu Lys Glu 
            180                 185                 190         


Lys Gln Lys Glu Asn Thr Arg Ile Lys Leu Asp Ser Glu Thr Ile Asn 
        195                 200                 205             


Asn Thr Ile Phe Asn Asn Ser Phe Ser His Leu Ile Tyr Arg Arg Lys 
    210                 215                 220                 


Lys Ala Asp Asn Asp Ile Leu Ser Ala Ser Cys Lys Ser Glu Tyr Lys 
225                 230                 235                 240 


Gly Glu Pro Thr Glu Asn Gly Ile Asn Val Ser Val Asp Gly Leu Leu 
                245                 250                 255     


Phe Phe Leu Gly Ile Phe Leu Ser Arg Lys Glu Ser Asn Asp Leu Arg 
            260                 265                 270         


Gly Arg Ile Lys Gly Phe Lys Gly Thr Val Ile Lys Asp Leu Pro Asp 
        275                 280                 285             


Phe Pro Asn Glu Lys Asn Asn Ser Leu Lys Phe Met Ala Thr His Trp 
    290                 295                 300                 


Val Phe Thr Tyr Leu Asn Ile Lys Pro Ile Lys Gln Lys Leu Asn Thr 
305                 310                 315                 320 


Asn Phe Ser Arg Glu Thr Leu Leu Leu Gln Ile Val Asp Glu Leu Thr 
                325                 330                 335     


Lys Ile Pro Asn Glu Ile Tyr Arg Asn Leu Cys Phe Lys Lys Gln Gln 
            340                 345                 350         


Glu Phe Val Glu Asp Ile Asn Glu Tyr Ile Lys Glu Gly Asp Asp Ile 
        355                 360                 365             


Asp Thr Leu Asn Ser Ser Thr Val Ile His Pro Val Ile Arg Lys Arg 
    370                 375                 380                 


Tyr Glu Asn Lys Phe Asn Tyr Phe Val Leu Arg Tyr Leu Asp Glu Phe 
385                 390                 395                 400 


Val Ser Phe Asn Ser Leu Arg Phe Gln Ile Tyr Leu Gly Asn Tyr Val 
                405                 410                 415     


His His Ile Gln Arg Lys Lys Leu Ser Gly Thr Glu Tyr Glu Thr Glu 
            420                 425                 430         


Arg Val Ile Lys Glu Lys Ile Asn Val Phe Gly Lys Leu Ser Glu Val 
        435                 440                 445             


Ser Asn Ile Lys Gly Asp Tyr Phe Ile Gln Asn Asn Pro Asp Asn Glu 
    450                 455                 460                 


Ala Leu Gly Trp Glu Ile Tyr Pro Asn Pro Ser Tyr Asn Phe Thr Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Ile Tyr Phe Asp Ile Asn Asp Gln Asp Lys Glu Lys 
                485                 490                 495     


Ile Asn Glu Tyr Lys Ser Ile Arg Asn Phe Ser Glu Lys Arg Ile Leu 
            500                 505                 510         


Arg Lys Lys Asn Lys Lys Asn Lys Gln Glu Ile Phe Asp Leu Ile Asn 
        515                 520                 525             


Asn Thr Leu Thr Thr Arg Val Phe Thr Ala Glu Pro Thr Ala Ile Leu 
    530                 535                 540                 


Ser Leu Asn Glu Leu Pro Ala Leu Leu Tyr Thr Ile Leu Cys Glu Asn 
545                 550                 555                 560 


Lys Thr Ala Ser Glu Ile Glu Asn Leu Leu Arg Arg Thr Tyr Leu Lys 
                565                 570                 575     


Arg Leu Asn Thr Ile Lys Asn Tyr Gln Pro Gly Thr Leu Pro Gln Ser 
            580                 585                 590         


Lys Ile Thr Lys Asn Leu Asn Lys Ser Thr Asn Gln Glu Ser Leu Asp 
        595                 600                 605             


Val Ser Lys Leu Ile Lys Ala Met Lys His Glu Ile Ser Ile Ser Asn 
    610                 615                 620                 


Glu Lys Leu Thr Leu Ile Lys Lys Asn Gln Asn Glu Val Lys Asp Thr 
625                 630                 635                 640 


Ser His Arg Arg Lys Tyr Val Phe Asn Ser Lys Glu Leu Gly Ile Glu 
                645                 650                 655     


Ala Thr Trp Leu Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Lys Val 
            660                 665                 670         


Arg Glu Asn Trp Lys Gly Tyr Met His Ser Gln Leu Gln Asn Ser Ile 
        675                 680                 685             


Ala Tyr Tyr Ser Gln Lys Pro Lys Glu Ala Leu Ser Ile Leu Ser Ser 
    690                 695                 700                 


Val Trp Asn Phe Asn Asp Asp Asn Tyr Ile Trp Asn Glu Gly Ile Lys 
705                 710                 715                 720 


Lys Ala Phe Asn Glu Lys Glu Phe Glu Lys Phe Tyr Cys Lys Tyr Leu 
                725                 730                 735     


Ala Ser Arg Asn Lys Thr Leu Glu Lys Leu Lys Glu Asn Leu Asp Asn 
            740                 745                 750         


Leu Glu Tyr Lys Thr Asp Lys Arg Lys Leu Asp Lys Phe Ile Lys Gln 
        755                 760                 765             


Gln Asn Leu Asp Cys Leu Phe His Ile Arg Thr Tyr Thr Ile Asp Ser 
    770                 775                 780                 


Thr Gln Glu Gln Ile Asn Lys Leu Leu Ala Lys Pro Leu Val Phe Pro 
785                 790                 795                 800 


Arg Gly Ile Phe Asp Ser Lys Pro Thr Phe Val Lys Asn Glu Ser Val 
                805                 810                 815     


Thr Glu Lys Pro Glu Leu Phe Ala Asp Trp Tyr Thr Tyr Thr Tyr Lys 
            820                 825                 830         


Glu His Pro Leu Gln Glu Phe Tyr Ser Phe Thr Lys Asp Tyr Glu Cys 
        835                 840                 845             


Asn Phe Lys Lys Glu Lys Leu Thr Val Lys Glu Phe Val Lys Asn Gln 
    850                 855                 860                 


Glu Gln Leu Asn Pro Glu Glu Gln Leu Asn Leu Phe Lys Leu Lys Glu 
865                 870                 875                 880 


Asp Leu Ser Ile Lys Cys Ile Lys Asn Gln Asp Leu Phe Leu Lys Leu 
                885                 890                 895     


Val Val Asp Asn Ile Tyr Asn Lys Ile Phe Glu Tyr Asn Ile Asp Ile 
            900                 905                 910         


Ser Leu Lys Asn Leu Tyr Ile Ser Arg Lys Glu Arg Ile Ala Ile Gly 
        915                 920                 925             


Leu Lys Ala Lys Glu Leu Asn Gln Ile Asn Asp Ser Tyr Ile Trp Gly 
    930                 935                 940                 


Lys Thr Ile Leu Tyr Gln Asp Lys Gln Ile Arg Glu Thr Lys Val Gln 
945                 950                 955                 960 


Leu Lys Asp Ile Asn Lys Ile Lys Arg Phe Leu Glu Glu Asp Lys Val 
                965                 970                 975     


Lys Gln Ile Leu Ser Tyr Asp Ile Asn Lys Gln Trp Glu Ile Glu Glu 
            980                 985                 990         


Leu Lys Tyr Glu Leu Tyr Ile Lys  Pro Asn Ser Tyr Glu  Val Ile Arg 
        995                 1000                 1005             


Arg Glu  Lys Leu Phe Lys Ala  Ile Gln Glu Phe Glu  Ser Tyr Ile 
    1010                 1015                 1020             


Leu Thr  Ile Asn Asn Phe Asp  Gly Ser Asn His Pro  Ser Ile Leu 
    1025                 1030                 1035             


Glu Tyr  Asn Ser Asn Pro Arg  Phe Lys His Tyr Val  Val Asn Gly 
    1040                 1045                 1050             


Leu Leu  Leu Lys Lys Gly Leu  Ala Thr Asn Glu Glu  Ile Glu Trp 
    1055                 1060                 1065             


Leu Leu  Ala Lys Gly Gln Lys  Glu Phe Asn Thr Phe  Asp Lys Ser 
    1070                 1075                 1080             


Ile Val  Glu Lys Pro Glu Ile  Ile Gln Lys Ala Phe  Leu Leu Val 
    1085                 1090                 1095             


Leu Ile  Arg Asn Lys Phe Ala  His Ser Gln Leu Pro  Ile Lys Glu 
    1100                 1105                 1110             


Tyr Tyr  Glu Met Ile Arg Ser  Tyr Thr Lys Asn Ile  Glu Asn Leu 
    1115                 1120                 1125             


Asn Thr  Thr Glu Ile Ile Phe  Gln Phe Thr Thr Asn  Thr Ile Asn 
    1130                 1135                 1140             


Glu Leu  Lys Arg 
    1145         


<210>  1941
<211>  1338
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1941

Met Ala Asn Val Gln Phe Gln Leu Val Pro Val Asp Tyr Ser Arg Pro 
1               5                   10                  15      


Tyr Asp Glu Gln Pro Glu Cys Lys Arg His Ile Ile Gly Ala Tyr Ala 
            20                  25                  30          


Asn Leu Ala Arg His Asn Met Thr Val Thr Ile Asn Thr Val Met Gln 
        35                  40                  45              


Ala Ile Gly Met Asn Leu Phe Asn Glu Asn Asp Ile Asp Asp Ala Phe 
    50                  55                  60                  


Asn Lys Ser His Arg Lys Lys Ile Ala Lys Leu Asp Asn Ile Gln Lys 
65                  70                  75                  80  


Val Asn Leu Gln Lys Arg Leu Tyr Arg His Phe Pro Phe Phe Lys Arg 
                85                  90                  95      


Met Lys Leu Glu Asp Glu Asn Lys Lys Ser Val Gln Leu Asn Thr Leu 
            100                 105                 110         


Leu Glu Val Met Ala Asp Phe Thr Ser Cys Met Ala Met Leu Arg Asn 
        115                 120                 125             


Tyr Tyr Thr His Tyr His Pro Tyr Asn Ser Phe Leu Glu Gln Glu Lys 
    130                 135                 140                 


Gln Phe Glu Leu Lys Lys Arg Met Gly Lys Arg Leu Gln Tyr Leu Tyr 
145                 150                 155                 160 


Glu Asn Thr Ala Gln Leu Phe Lys Ser Asn Glu Ser Leu Pro His Glu 
                165                 170                 175     


Ala Asn Glu Val Phe Ala Thr Leu Arg Ile Pro Glu Asp Tyr Val Glu 
            180                 185                 190         


Glu Phe Met Pro Gly Asp Glu Gly Tyr Asp Glu Leu Leu Lys Leu Ile 
        195                 200                 205             


Thr Asp Pro Arg Thr Asn Ser Phe Lys Lys Lys Gly Leu Lys Leu Glu 
    210                 215                 220                 


Met Lys Ser Gln Lys Ile Thr Arg Lys Ser Leu Arg Tyr Val Arg Asn 
225                 230                 235                 240 


Pro Glu Tyr Gln Ala Tyr Met Met Asp Asp Ser Lys Gly Met Ser Asp 
                245                 250                 255     


Val Ala Ile Ile Tyr Phe Leu Cys Leu Phe Leu Glu Lys Lys Val Ala 
            260                 265                 270         


Phe Glu Leu Met Glu Glu Val Gly Phe Thr Lys Gln Val Lys Phe Thr 
        275                 280                 285             


Gly Lys Asn Ala Asp Gln Gln Leu Leu Phe Val Lys Glu Ile Met Cys 
    290                 295                 300                 


Met Asn Arg Ile Arg Met Thr Lys Thr Lys Leu Asp Ser Glu Met Thr 
305                 310                 315                 320 


Asp Thr Ala Leu Ala Leu Asp Met Ile Ser Glu Leu Arg Lys Cys Pro 
                325                 330                 335     


Lys Pro Leu Tyr Glu Val Phe Cys Lys Glu Ala Arg Asp Glu Phe Lys 
            340                 345                 350         


Asp Asp Ala Thr Val Ser Trp Glu Arg Ile His Asn Glu Glu Ala Val 
        355                 360                 365             


Ala Thr Glu Glu Thr Thr Glu Asp Glu Asn Asn Gly Ala Glu Ser Val 
    370                 375                 380                 


Asp Lys Asn Thr Pro Arg Ser Thr Phe Val Arg Trp Glu Asp Arg Phe 
385                 390                 395                 400 


Pro Gln Met Ala Leu Arg Tyr Ile Asp Cys Gln Gly Leu Phe Asp Asp 
                405                 410                 415     


Ile Arg Phe Gln Leu Asn Leu Gly Lys Tyr Arg Phe Ala Phe Tyr Gln 
            420                 425                 430         


His Asp Ala Ser Tyr Ser Val Asp Asn Glu Glu Arg Leu Arg Ile Leu 
        435                 440                 445             


Gln Lys Glu Leu His Gly Phe Gly Arg Ile Gln Glu Val Asn Pro Gln 
    450                 455                 460                 


Met Lys Glu Lys Trp Ala Thr Leu Phe Asp Glu Lys Tyr Val Glu Asp 
465                 470                 475                 480 


Gly Leu Thr Gln Lys Arg Pro Asp Gln Ser Gly Gln Ala Pro Tyr Val 
                485                 490                 495     


Thr Glu Gln Asp Ala Gln Tyr Ala Ile Asp Asp Lys Ser His Ser Val 
            500                 505                 510         


Gly Leu Arg Trp Glu Gly Phe Glu Ala Thr Gly Asp Pro His Lys His 
        515                 520                 525             


Tyr Gly Asp Leu Asp Ala Gln Lys Met Phe Ile Pro Tyr Leu Pro Thr 
    530                 535                 540                 


Asn Leu Gln Lys Asp Thr Thr Lys Thr Asn Gln Ala Glu Pro Leu Leu 
545                 550                 555                 560 


Ala Pro Gln Ala Met Leu Ser Leu Tyr Glu Leu Pro Ala Leu Leu Phe 
                565                 570                 575     


Tyr Gln Tyr Leu Ser Val Lys Tyr Gly Arg Ser Lys Phe Glu Ala Glu 
            580                 585                 590         


Asn Val Ile Lys Asp Tyr Tyr Lys Asn Ile Arg Ser Phe Leu Asp Asp 
        595                 600                 605             


Phe Ser Lys Gly Gln Ile His Pro Ile Gly Gly Thr Pro Val Arg Asp 
    610                 615                 620                 


Val Lys Lys Gln Glu Glu Leu Trp Thr Gln Arg Lys Thr Glu Leu Asn 
625                 630                 635                 640 


Glu Ile Leu Gln Lys Tyr Asn Leu Lys Asp Ser Asp Ile Pro Ser Lys 
                645                 650                 655     


Leu Arg Tyr Tyr Leu Cys Ser Lys Glu Val Asp Tyr Asp Gln Lys Leu 
            660                 665                 670         


Leu Asp Ser Ala Leu Asn Arg Leu Asn Glu Arg Lys Lys Arg Val Glu 
        675                 680                 685             


Lys Ser Lys Glu Ser Phe Asn Glu Lys Lys Lys Leu Ile Gly Thr Lys 
    690                 695                 700                 


Gln Asn Lys Phe Asp Arg Met Arg Ala Thr Ile Lys Thr Gly Gln Leu 
705                 710                 715                 720 


Ala Gln Trp Leu Ile Arg Asp Ile Trp Asp Trp Leu Pro Asn Asn Ser 
                725                 730                 735     


Ile Cys Arg Lys Lys Leu Ser Gly Gln Ser Tyr Ala Val Leu Gln Ser 
            740                 745                 750         


Ser Leu Ala Met Leu Gly Gln Gln Phe Ser Glu Thr Gly Val Asp Ile 
        755                 760                 765             


Leu Asn Val Asn Arg Leu Lys Ser Met Phe Thr Lys Ala Gly Val Ile 
    770                 775                 780                 


Ser Gln Ser Gly Glu Ile Asp Lys Asn Gln His His Pro Phe Leu Asn 
785                 790                 795                 800 


Glu Val Phe Ser Gln Cys Gln Ile Asp Ser Val Glu Tyr Phe Tyr Glu 
                805                 810                 815     


Thr Tyr Leu Asp Cys Glu Leu Thr His Ile Glu Asn Val Asp Lys Glu 
            820                 825                 830         


Ile Arg Glu Gly Ser Asp Phe Asp Asp Tyr Leu Lys Ile Pro Phe Leu 
        835                 840                 845             


His Cys Glu Arg Arg Arg Trp Cys Glu Gln Asp Phe Asn Ser Leu Arg 
    850                 855                 860                 


Asn Leu Ala Lys Arg Tyr Leu Asn Arg Pro Ile Gln Leu Pro Asp Gly 
865                 870                 875                 880 


Leu Phe Ala Lys Ser Ile Phe Asn Leu Leu Leu Glu Ala Glu Pro Lys 
                885                 890                 895     


Leu Lys Val Ala Leu Met Thr Ile Arg Gly Ala Ala Asn Asn Gln Gln 
            900                 905                 910         


Leu Asp Asn Asn Thr Ala Tyr Leu Ile Arg Leu Tyr Met Glu Glu Val 
        915                 920                 925             


Glu Gly Asp His Ser Gln Pro Phe Tyr Ser Thr Ala Pro Ile Asp Gly 
    930                 935                 940                 


Ala Pro Ser Pro Tyr Arg His Val Tyr Arg Leu Phe Lys Lys Tyr Phe 
945                 950                 955                 960 


Gly Gln Ser Ile Pro Gly Thr Asn Gln Thr Thr Thr Pro Ala Tyr Thr 
                965                 970                 975     


Ile Glu Glu Ile Arg Glu Ile Leu Lys Asp Lys Ser Lys Leu Met Glu 
            980                 985                 990         


Leu Ile Leu Asn His Ile Ala Asp  Asp Leu Ala Lys Phe  Arg Glu Lys 
        995                 1000                 1005             


Lys Lys  Lys Lys Val Lys Ser  Phe Asn Leu Lys Ala  Phe Ile Asp 
    1010                 1015                 1020             


Leu Gln  Trp Lys Ile Val Lys  Asp Glu Asn Ala Thr  Gly Lys Ala 
    1025                 1030                 1035             


Lys Arg  Asn Phe Gln Gln Arg  Lys Gln Glu Val Asp  Lys Arg Ile 
    1040                 1045                 1050             


Asn Ala  Lys Lys Lys Glu Leu  Glu Gly Leu Arg Ala  Lys Ile Glu 
    1055                 1060                 1065             


Lys Glu  Val Asp Glu Tyr Glu  Lys Lys Leu Ile Gln  Lys Gln Lys 
    1070                 1075                 1080             


Arg Gln  Phe Asp Lys Val Ala  Asp Asn Glu Arg Ile  Ile Arg Arg 
    1085                 1090                 1095             


Phe Lys  Thr Gln Asp Val Leu  Met Phe Val Met Ala  Arg Glu Ile 
    1100                 1105                 1110             


Leu Lys  Ala Lys Ser Lys Asp  Arg Asp Phe Thr Lys  Gly Phe Cys 
    1115                 1120                 1125             


Leu Lys  Tyr Val Met Thr Asp  Ser Leu Leu Ser Lys  Pro Ile Asp 
    1130                 1135                 1140             


Phe Asp  Trp Arg Val Asn Ile  Lys Glu Lys Asp Lys  Lys Pro Val 
    1145                 1150                 1155             


Thr Lys  Thr Ile Arg Gln Glu  Gly Met Lys Met Lys  Asn Tyr Gly 
    1160                 1165                 1170             


Gln Phe  Tyr Lys Phe Ala Ser  Asp His Gln Arg Leu  Glu Ser Leu 
    1175                 1180                 1185             


Leu Ser  Arg Leu Pro Gly Glu  Ile Phe Leu Arg Ala  Glu Ile Glu 
    1190                 1195                 1200             


Asn Glu  Phe Ser Tyr Tyr Asp  Thr Asn Arg Ser Glu  Val Phe Arg 
    1205                 1210                 1215             


Gln Val  Tyr Ile Ile Glu Ser  Glu Ala Tyr Arg Leu  Lys Pro Glu 
    1220                 1225                 1230             


Leu Leu  Asp Asp Ser Asn Ala  Asn Glu Gly Trp Phe  Tyr Tyr Ser 
    1235                 1240                 1245             


Asp Asn  Arg Thr Gly Lys Gln  Arg Pro Ile Arg Asn  Ser Phe Ile 
    1250                 1255                 1260             


Gln Leu  Leu Glu Ile Leu Ala  Ala Gly Lys Asp Gly  Ile Leu Asp 
    1265                 1270                 1275             


Asp Asn  Glu Lys Val Ala Met  Gln Thr Thr Arg Asn  Ala Phe Gly 
    1280                 1285                 1290             


His Asn  Thr Tyr Asp Val Asp  Leu Asp Ala Val Phe  Glu Gly Asn 
    1295                 1300                 1305             


Glu Gln  Lys Lys Lys Ile Pro  Glu Val Ser Asn Gly  Ile Thr Ser 
    1310                 1315                 1320             


Lys Ile  Lys Glu Gly Thr Thr  Glu Leu Lys Lys Lys  Leu Glu Glu 
    1325                 1330                 1335             


<210>  1942
<211>  1126
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1942

Met Glu Thr Asn Gln Lys Pro Asn Tyr Lys Lys Phe Thr Asn Glu Gln 
1               5                   10                  15      


Asp Lys Pro Phe Phe Ser Gly Tyr Leu Asn Thr Ala Lys Gln Asn Val 
            20                  25                  30          


Phe Ile Ile Phe Arg Asp Ile Ser Glu Arg Leu Gly Leu Gly Phe Asp 
        35                  40                  45              


Leu Ser Asn Asp Asp Asn Ile Met Asn Ala Asp Leu Trp Glu Tyr Leu 
    50                  55                  60                  


Lys Asn Asn Lys Arg Pro Glu Ile Thr Gln His Ile Ile Glu Lys Leu 
65                  70                  75                  80  


Met Tyr His Phe Pro Phe Ala Ser His Leu Thr Thr Asn Tyr Ala Tyr 
                85                  90                  95      


Tyr Lys Arg Lys Glu Asn Gln Ala Glu Pro Leu Asp Tyr Tyr Glu Ile 
            100                 105                 110         


Phe Glu Leu Leu Ile Lys Gln Leu Tyr Glu Tyr Arg Asn Phe Tyr Thr 
        115                 120                 125             


His Val Val His Asp Pro Val Ile Met Asn Lys Val Ile Ile Asn Gly 
    130                 135                 140                 


Met Arg Ile Leu Phe Asp Ala Ala Arg Ile Glu Val Lys Asp Arg Phe 
145                 150                 155                 160 


Asn Leu Lys Thr Glu Asp Val Asn His Leu Val Arg Leu Gly Pro Lys 
                165                 170                 175     


Gly Lys Glu Asn Lys Asn Phe Tyr Tyr Asn Phe Ser Asp Asp Glu Arg 
            180                 185                 190         


Asn Val Ser Glu Lys Gly Leu Ala Phe Phe Ile Cys Leu Gly Leu Gln 
        195                 200                 205             


Arg Lys Asp Ala Gln Ile Phe Leu Lys Ser Leu Val Gly Phe Lys Leu 
    210                 215                 220                 


Ser Glu Ser Pro Ser Gln Lys Ala Thr Leu Glu Val Tyr Thr Asn Tyr 
225                 230                 235                 240 


Ser Pro Arg Ile Pro Gln Pro Arg Leu Thr Ser Asp Asn Ser Ile Glu 
                245                 250                 255     


Gly Leu Leu Leu Asp Met Val Asn Glu Leu Lys Arg Cys Pro Lys Glu 
            260                 265                 270         


Leu Tyr His Leu Leu Ser Ile Glu Asp Arg Glu Lys Phe Lys Ala Val 
        275                 280                 285             


Lys Glu Asp Asn Thr Tyr Asp Asp Asn Asp Glu Tyr Glu Ala Met Pro 
    290                 295                 300                 


Val Leu Lys Arg Ser Arg Asn Arg Phe Phe Tyr Phe Ala Leu Arg Tyr 
305                 310                 315                 320 


Leu Asp Asn Asn Leu Gln Asn Ile Lys Phe His Ile Asp Leu Gly Asn 
                325                 330                 335     


Tyr Cys Phe His Val Tyr Glu Gln Glu Ile Glu Glu Ile Val Arg Lys 
            340                 345                 350         


Arg Arg Trp Ile Lys Arg Met Thr Ser Phe Gly Asn Leu Glu Asp Phe 
        355                 360                 365             


Ala Asp Lys Met Arg Pro Ala Tyr Trp Val Glu Lys Thr Leu Lys Leu 
    370                 375                 380                 


Glu Asp Lys Lys Val Asp Asn Pro Asn Ile Tyr Ile Thr Asp Thr Thr 
385                 390                 395                 400 


Pro His Tyr His Ile Asn Gly Gln Asn Ile Gly Ile Lys Phe Ile Asn 
                405                 410                 415     


Asn Tyr Val Ala Leu Arg Lys Asn Asn Lys Ile Trp Pro Glu Leu Pro 
            420                 425                 430         


Asp Phe Gly Asp Asn Asn Lys Thr Asn Lys Pro Arg Asn Glu Thr Pro 
        435                 440                 445             


Asp Cys Trp Leu Ser Leu Tyr Glu Leu Pro Ser Ile Val Phe Tyr His 
    450                 455                 460                 


Leu Leu Lys Gln Gln Asn Ile Gly Leu Pro Ser Val Glu Arg Ile Ile 
465                 470                 475                 480 


Asn Asp His Arg Asn Gln Ile Arg Gly Phe Phe Asn Asp Leu Glu Asn 
                485                 490                 495     


Asn Arg Ile Val Pro Ser Phe Thr Asp Thr Thr Leu Lys Ala Glu Leu 
            500                 505                 510         


Lys Asn Arg Gly Leu Lys Lys Ser Gln Ile Pro Ser Ala Ile Val Lys 
        515                 520                 525             


Tyr Leu Thr Ser Lys Pro Val Met Ser Phe Glu Ala Lys Ala Ser Lys 
    530                 535                 540                 


Arg Leu Ser Glu Leu Val Thr Glu Thr Ser Glu Lys Leu Asp Lys Ile 
545                 550                 555                 560 


Lys Arg Gln Glu Gln His Tyr Leu Lys Lys Pro Gly Ser Lys Asp Tyr 
                565                 570                 575     


Ile Asp Met Lys Cys Gly His Leu Ala Asp Phe Leu Ala Arg Asp Met 
            580                 585                 590         


Ile Ser Leu Gln Lys Pro Tyr Asn Asn Met Asp Gly Lys Ala Asn Ser 
        595                 600                 605             


Thr Glu Phe Gln Ile Leu Gln Ser Lys Leu Ala Tyr Phe Gly Lys Asn 
    610                 615                 620                 


Lys Asp Ser Leu Ser Lys Thr Phe His Leu Phe Asn Leu Met Gly Ser 
625                 630                 635                 640 


Gln Asn Ile His Pro Phe Leu Tyr Lys Ile Asp Ile Asn Gln Cys Ile 
                645                 650                 655     


Gly Ile Leu Asp Phe Tyr Lys Lys Tyr Leu Asp His Arg Tyr Ile Tyr 
            660                 665                 670         


Phe Lys Gln Cys Leu Asn Glu Lys Arg Tyr Ser Glu Tyr His Phe Leu 
        675                 680                 685             


Lys Leu Gly Gly Lys Ser Lys Glu Gln Gly Arg Asp Tyr Phe Val Lys 
    690                 695                 700                 


Leu Ala Asn Thr Leu Gln Lys Glu Thr Val Met Asn Leu Pro Arg Gly 
705                 710                 715                 720 


Leu Phe Leu Glu Ser Ile Ile Arg Ile Leu Lys Ala Asn Asp Asn Ser 
                725                 730                 735     


Arg Pro Phe Ala Ile Glu Ile Glu Lys Met Glu Arg Val Asn Ala Ala 
            740                 745                 750         


Tyr Val Ile Asp Gln Tyr Leu Gly Arg Ile Leu Asn Asp Lys Pro Gln 
        755                 760                 765             


Val Phe Tyr Ser Tyr Asn Lys Ser Tyr Glu Phe Leu Asn Lys Leu Phe 
    770                 775                 780                 


Asp Ser Arg Lys Ile Ser Glu Lys Arg Asn Ala Leu Pro Glu Val Tyr 
785                 790                 795                 800 


Phe Asp Thr Gly Glu Leu Ala Lys Lys Thr Thr Ile Ser Val Lys Gly 
                805                 810                 815     


Gln Lys Asp Asn Glu Ile Thr Arg Ser Leu Thr Lys Thr Val Glu Gln 
            820                 825                 830         


His Ile Lys Arg Asn Arg Ile Phe Asp Glu Lys Glu Lys Thr Lys Val 
        835                 840                 845             


Tyr Asp Gln Tyr Met Ala Arg Tyr Asn Asp Phe Thr Glu Asn Glu Lys 
    850                 855                 860                 


Gln Ile Arg Leu Ala Lys Thr Cys Asp Glu Val Met Phe Met Met Ile 
865                 870                 875                 880 


Asp Asp Ile Phe Arg Lys Tyr Phe Val Leu Asp Asn Gly Thr Leu Lys 
                885                 890                 895     


Lys Lys Thr Ile Glu Ala Ile Pro Phe Ile Gln Leu Gly Asp Asp Tyr 
            900                 905                 910         


Lys Leu Gly Ser Ile Lys Pro Asp Ser Glu Lys Gly Phe Leu Ser Leu 
        915                 920                 925             


Gln Thr Thr Val Lys Leu Gln Met Pro Phe Thr Tyr Glu Thr Asn Thr 
    930                 935                 940                 


Asp Lys Val Leu Lys Val Lys Gly Ala Glu Ser Lys Leu Ser Ala Arg 
945                 950                 955                 960 


Tyr Ile Lys Thr Ile Val Arg Glu Thr Ile Lys Ile Lys Asn Tyr Gly 
                965                 970                 975     


Asp Phe Arg Ala Phe Leu Lys Asp Arg Arg Ile Ser Ser Leu Leu Pro 
            980                 985                 990         


Tyr Leu Ser Asp Arg Glu Ile His  Tyr Glu Ala Leu Gln  Lys Glu Leu 
        995                 1000                 1005             


Glu Leu  Phe Gln Lys Ala Arg  Met Glu Val Phe Asp  Arg Ile Phe 
    1010                 1015                 1020             


Arg Phe  Glu Lys Asp Ile Thr  Gly Ala Phe His Ile  Pro Lys Asn 
    1025                 1030                 1035             


Lys Asn  Gly Tyr Ile Tyr His  Thr Glu Ile Leu Lys  Gln Lys Ile 
    1040                 1045                 1050             


Asn Glu  Gly Asp Glu Arg Phe  Gly Phe Ile Lys Glu  Leu Arg Asn 
    1055                 1060                 1065             


Ala Phe  Asn His Ser Asn Tyr  Pro Ala Tyr Val Leu  Phe Lys Asp 
    1070                 1075                 1080             


Phe Ile  Asp Gly Ser Gln Phe  Asn Glu Leu Arg Asn  Tyr Lys Ser 
    1085                 1090                 1095             


Gly Asp  Thr Glu Val Glu Asn  Lys Ser Val Ile Leu  Gln Phe Lys 
    1100                 1105                 1110             


Asn Leu  Leu Ile Gln Tyr Tyr  Asp Glu Leu Thr Asp  Leu 
    1115                 1120                 1125     


<210>  1943
<211>  1152
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1943

Met Glu Thr Gln Ile Leu Gly Gln Gly Ile Ser Tyr Asp His Thr Lys 
1               5                   10                  15      


Ile Glu Asp Lys His Phe Phe Gly Gly Phe Leu Asn Ser Ala Arg Asn 
            20                  25                  30          


Asn Val Asp Leu Leu Ile Thr Ala Phe Gly Ala Lys Phe Gly Phe Ser 
        35                  40                  45              


Asn Lys Leu Ser Leu Thr Gln Phe Val Glu Val Cys Phe Lys Pro Glu 
    50                  55                  60                  


Asp Ser Asp Glu Asp Phe Gln Asn Lys Leu Arg Phe Val Arg Met His 
65                  70                  75                  80  


Leu Pro Val Val Gln Tyr Leu Arg Phe Gln Gly Asp Arg Thr Val Leu 
                85                  90                  95      


Arg Gln Lys Phe Ala Leu Leu Leu Gln Ala Ile Asp Gly Leu Arg Asn 
            100                 105                 110         


Phe Tyr Thr His Tyr Tyr His Lys Pro Leu His Leu Ser Asn Glu Leu 
        115                 120                 125             


Phe Val Leu Leu Asp Asp Ile Phe Ala Ala Val Ala Asp Asp Val Lys 
    130                 135                 140                 


Lys Asn Lys Met Lys Asp Asp Lys Thr Arg His Leu Leu Lys Lys Asn 
145                 150                 155                 160 


Leu Lys Glu Glu Leu Asp Ile Arg Tyr Lys Gln Gln Val Glu Lys Leu 
                165                 170                 175     


Lys Lys Leu Lys Ser Glu Gly Lys Lys Val Asn Leu Asn Asp Thr Glu 
            180                 185                 190         


Ala Ile Lys Asn Gly Val Leu Asn Gly Ala Phe Asn His Leu Ile Phe 
        195                 200                 205             


Lys Asp Glu Glu Val Ile Lys Pro Thr Val Ser Tyr Ser Ser Tyr Tyr 
    210                 215                 220                 


Tyr Gly Ser Asp Ser Ala Glu Asn Gly Ile Cys Ile Ser Gln Ser Gly 
225                 230                 235                 240 


Leu Leu Phe Leu Leu Ser Met Phe Leu Gly Arg Lys Glu Thr Glu His 
                245                 250                 255     


Leu Lys Ser Arg Ile Lys Gly Phe Lys Ala Arg Ile Ile Lys His Glu 
            260                 265                 270         


Glu Glu His Ile Ser Gly Leu Lys Phe Met Ala Thr His Trp Val Phe 
        275                 280                 285             


Ser Gln Leu Cys Phe Lys Gly Val Lys Pro Lys Leu Asn Thr Asp Phe 
    290                 295                 300                 


His Glu Glu Thr Leu Leu Ile Gln Ile Ile Asp Glu Leu Ser Lys Val 
305                 310                 315                 320 


Pro Asp Glu Leu Tyr Arg Ser Phe Asp Lys Glu Thr Lys Thr Lys Phe 
                325                 330                 335     


Ile Glu Asp Ile Asn Glu Tyr Ile Arg Glu Gly Lys Val Asp Leu Ser 
            340                 345                 350         


Leu Glu Glu Ser Lys Ile Val His Pro Val Ile Arg Lys Arg Tyr Glu 
        355                 360                 365             


Ser Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe Phe Asp 
    370                 375                 380                 


Phe Pro Ser Leu Arg Phe Gln Val His Val Gly Asn Phe Val His Asp 
385                 390                 395                 400 


Arg Arg Ile Lys His Ile Ala Gly Thr Asp Phe Gln Thr Glu Arg Leu 
                405                 410                 415     


Val Lys Asp Arg Ile Lys Val Phe Gly Lys Leu Ser Thr Ile Ser Arg 
            420                 425                 430         


Leu Lys Ala Glu His Leu Thr Glu Ile Ile Gly Leu Asn Lys Asp Thr 
        435                 440                 445             


Gly Trp Glu Leu Leu Pro Asn Pro Ser Tyr Val Phe Ile Glu Asn Asn 
    450                 455                 460                 


Ile Pro Ile His Ile Ser Ala Asp Lys Ser Phe Lys Asn Gly Ile Lys 
465                 470                 475                 480 


Glu Phe Lys Asp Lys Arg Lys Ala Glu Lys Pro Glu Glu Met Lys Lys 
                485                 490                 495     


Arg Glu Gln Gly Lys Met Gln Lys Phe Glu Ile Ser Lys Leu Ile Gly 
            500                 505                 510         


Val Lys Asn Asp Ile Asn Pro Glu Ser Pro Ile Ala Leu Leu Ser Met 
        515                 520                 525             


Asn Glu Ile Pro Ala Leu Leu Tyr Glu Ile Leu Val Asn Asn Val Ser 
    530                 535                 540                 


Pro Glu Glu Ile Glu Glu Lys Leu Lys Asn Lys Leu Asn Ile Gly Phe 
545                 550                 555                 560 


Glu Arg Ile Arg Asp Tyr Asp Pro Ile Thr Pro Leu Pro Ala Ser Met 
                565                 570                 575     


Ile Ser Lys Arg Leu Arg Asn Asn Thr Asp Gly Lys Ser Val Asn Thr 
            580                 585                 590         


Glu Lys Leu Ile Ser Leu Ile Glu Arg Glu Ile Glu Lys Thr Asp Glu 
        595                 600                 605             


Lys Leu Ile Leu Ile Ala Lys Asn Arg Arg Glu Cys Arg Val Arg Phe 
    610                 615                 620                 


Arg Gly Lys Ala Ile Arg Gln Gln Val Phe Arg Asn Ser Glu Leu Gly 
625                 630                 635                 640 


Val Glu Ala Thr Trp Leu Ala Asp Asp Ile Lys Arg Phe Met Pro Ala 
                645                 650                 655     


Val Gln Lys Lys Asn Trp Lys Gly Tyr Gln His Ser Gln Phe Gln Gln 
            660                 665                 670         


Ser Leu Ala Phe Phe Glu Lys Arg Pro His Glu Ala Arg Ser Ile Leu 
        675                 680                 685             


Gln Ala Gly Trp Asp Phe Ser Asp Gly Ser Ser Phe Trp Asn Gly Trp 
    690                 695                 700                 


Ile Met Asn Ser Phe Thr Lys Asp Lys Thr Phe Asp Gly Phe Tyr Glu 
705                 710                 715                 720 


Thr Tyr Leu Tyr Gly Arg Gln Lys Tyr Phe Thr Arg Leu Ser Glu Asn 
                725                 730                 735     


Ile Ala Gln His Ser Thr Asn Ala Lys Asn Leu Arg Lys Phe Met Asp 
            740                 745                 750         


Gln Gln Met Pro Lys Gly Leu Phe Glu Asn Arg Leu Tyr Met Leu Glu 
        755                 760                 765             


Asp Leu Asn Thr Glu Lys Arg Lys Ile Leu Ser Lys Pro Leu Ile Phe 
    770                 775                 780                 


Ser Arg Gly Ile Phe Asp Glu Lys Pro Thr Phe Ile Lys Gly Val Lys 
785                 790                 795                 800 


Val Thr Glu Asn Pro Glu Gly Phe Ala Asp Trp Tyr Lys Tyr Gly Tyr 
                805                 810                 815     


Ala Pro Lys His Lys Phe Gln Asn Tyr Tyr Trp Trp Glu Arg Asn Tyr 
            820                 825                 830         


Asp Asp Leu Leu Glu Glu Glu Leu Ala Lys Asp Thr Asp Phe Ala Lys 
        835                 840                 845             


Asn Ser Phe Lys Tyr Asp Arg Lys Ser Gln Ile Glu Leu Leu Ala Lys 
    850                 855                 860                 


Lys Gln Asp Leu Lys Ile Lys Asn Ile Lys Ile Gln Asp Leu Phe Leu 
865                 870                 875                 880 


Lys Leu Met Ala Glu Phe Leu Phe Gln Lys Val Phe Asp His Ser Val 
                885                 890                 895     


Glu Leu Ser Leu Asp His Leu Phe Leu Ser Gln Glu Glu Arg Leu Glu 
            900                 905                 910         


Lys Glu Arg Val Ala His Leu Gln Ser Gln Arg Met Glu Gly Asp Asp 
        915                 920                 925             


Ser Pro Asn Ile Leu Lys Glu Asp Phe Ile Trp Ser Lys Thr Leu Ala 
    930                 935                 940                 


Tyr Glu Asp Gly Gln Ile Tyr Glu Pro Arg Val Lys Leu Lys Asp Leu 
945                 950                 955                 960 


Gly Lys Leu Lys Ala Leu Leu Leu Asp Asp Lys Val Lys Thr Leu Leu 
                965                 970                 975     


Ser Tyr Asp Ser Asp Lys Arg Trp Asn Arg Leu Ala Ile Asp Asn Glu 
            980                 985                 990         


Met Ser Ile Gly Ser Asp Ser Tyr  Glu Ser Ile Arg Arg  Glu Leu Leu 
        995                 1000                 1005             


Phe Lys  Glu Ile Gln Gln Met  Glu Lys Thr Thr Leu  Glu Asn Trp 
    1010                 1015                 1020             


Pro Trp  Asp Gly Ile Ala His  Pro Ala Glu Phe Glu  Phe Ala Asp 
    1025                 1030                 1035             


Lys Thr  Gly Val Arg His Pro  Asn Phe Lys His Tyr  Ile Val Asn 
    1040                 1045                 1050             


Gly Ile  Leu Arg Lys Lys Pro  Gly Leu Val Glu Glu  Gln Glu Ala 
    1055                 1060                 1065             


Lys Trp  Ile Glu Asp Cys Asp  Glu Glu Ile Phe Lys  Asn Leu Ser 
    1070                 1075                 1080             


Glu Asn  Asp Leu Ala Lys Lys  Thr Glu Pro Ile Gln  Leu Ala Phe 
    1085                 1090                 1095             


Leu Val  Ile Met Ile Arg Asn  Gln Phe Ala His Asn  His Leu Pro 
    1100                 1105                 1110             


Ala Lys  Gln Phe Tyr Glu Phe  Ile Lys Gln Thr Tyr  Pro Glu Ile 
    1115                 1120                 1125             


Gln Gly  Thr Thr Val Ser Glu  Phe Tyr Leu Gln Phe  Met Arg Phe 
    1130                 1135                 1140             


Ala Ile  Gln Arg Met Leu Asn  Leu Asn 
    1145                 1150         


<210>  1944
<211>  1118
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1944

Met Glu Asp Asp Lys Lys Thr Lys Glu Ser Ile Ser Tyr Glu Leu Glu 
1               5                   10                  15      


Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val 
            20                  25                  30          


Tyr Ile Thr Val Asn His Ile Asn Lys Ile Leu Glu Glu Gly Glu Ile 
        35                  40                  45              


Asn Arg Asp Gly Tyr Glu Lys Thr Leu Glu Asn Ser Trp Asn Glu Ile 
    50                  55                  60                  


Lys Asp Ile Asn Lys Lys Asp Arg Leu Ser Lys Leu Ile Ile Lys His 
65                  70                  75                  80  


Phe Pro Phe Leu Glu Ala Thr Thr Tyr Arg Leu Asn Pro Thr Asp Thr 
                85                  90                  95      


Thr Lys Gln Lys Glu Glu Lys Gln Ala Glu Ala Gln Ser Leu Glu Ser 
            100                 105                 110         


Leu Lys Glu Ser Phe Phe Val Phe Ile Tyr Lys Leu Arg Asp Leu Arg 
        115                 120                 125             


Asn His Tyr Ser His Tyr Lys His Ser Lys Ser Leu Glu Arg Pro Lys 
    130                 135                 140                 


Phe Glu Glu Gly Leu Gln Lys Lys Met Tyr Asn Ile Phe Asn Ala Ser 
145                 150                 155                 160 


Ile Gln Leu Val Lys Glu Asp Tyr Lys His Asn Thr Asp Ile Lys Thr 
                165                 170                 175     


Glu Glu Asp Phe Lys His Leu Asp Arg Lys Gly Gln Phe Lys Tyr Ser 
            180                 185                 190         


Phe Ala Asp Asn Glu Gly Asn Ile Thr Glu Ser Gly Leu Leu Phe Phe 
        195                 200                 205             


Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Val Gln Lys Lys 
    210                 215                 220                 


Leu Glu Gly Phe Lys Cys Ser Asn Glu Ser Tyr Gln Lys Met Thr Asn 
225                 230                 235                 240 


Glu Val Phe Cys Arg Ser Arg Met Leu Leu Pro Lys Leu Arg Leu Gln 
                245                 250                 255     


Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu Asn Glu Leu 
            260                 265                 270         


Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Arg Gly Glu Asp Arg 
        275                 280                 285             


Glu Lys Phe Arg Val Pro Leu Asp Pro Ile Asp Glu Asp Tyr Asp Ala 
    290                 295                 300                 


Glu Gln Glu Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
305                 310                 315                 320 


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Tyr Asn Glu Ile Phe Thr Asn 
                325                 330                 335     


Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile Tyr Lys 
            340                 345                 350         


Lys Leu Ile Gly Gly Asn Lys Glu Asp Arg His Leu Thr His Lys Leu 
        355                 360                 365             


Tyr Gly Phe Glu Arg Ile Gln Glu Phe Asp Lys Gln Asn Arg Pro Asp 
    370                 375                 380                 


Glu Trp Lys Ala Ile Val Lys Asp Ser Asp Thr Phe Lys Lys Lys Glu 
385                 390                 395                 400 


Glu Lys Glu Glu Glu Lys Pro Tyr Ile Ser Glu Thr Thr Pro His Tyr 
                405                 410                 415     


His Leu Glu Asn Lys Lys Ile Gly Ile Ala Phe Lys Asn His Asn Ile 
            420                 425                 430         


Trp Pro Ser Thr Gln Thr Glu Leu Thr Asn Asn Lys Arg Lys Lys Tyr 
        435                 440                 445             


Asn Leu Gly Thr Ser Ile Lys Ala Glu Ala Phe Leu Ser Val His Glu 
    450                 455                 460                 


Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Lys Thr Glu Asn Thr 
465                 470                 475                 480 


Lys Asn Asp Asn Lys Val Glu Gly Lys Lys Glu Thr Lys Lys Gln Glu 
                485                 490                 495     


Lys His Lys Ile Glu Ala Ile Ile Glu Ser Lys Ile Lys Asp Met Tyr 
            500                 505                 510         


Ala Leu Tyr Asp Ala Phe Ala Asn Gly Glu Ile Asn Ser Glu Lys Glu 
        515                 520                 525             


Leu Glu Glu Tyr Leu Lys Gly Lys Asp Ile Glu Ile Val His Leu Pro 
    530                 535                 540                 


Lys Gln Met Ile Ala Ile Leu Lys Asn Lys His Lys Asp Met Val Glu 
545                 550                 555                 560 


Lys Ala Glu Ala Lys Gln Glu Lys Met Lys Leu Ala Thr Glu Asn Arg 
                565                 570                 575     


Leu Lys Thr Leu Asp Lys Gln Leu Lys Gly Lys Ile Gln Asn Gly Lys 
            580                 585                 590         


Arg Tyr Asn Ser Ala Pro Lys Ser Gly Glu Ile Ala Ser Trp Leu Val 
        595                 600                 605             


Asn Asp Met Met Arg Phe Gln Pro Val Gln Arg Asp Glu Asn Gly Glu 
    610                 615                 620                 


Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln Leu Leu Gln 
625                 630                 635                 640 


Arg Thr Leu Ala Phe Phe Gly Ser Glu His Glu Arg Leu Ala Pro Tyr 
                645                 650                 655     


Phe Lys Gln Thr Lys Leu Ile Glu Ser Ser Asn Pro His Pro Phe Leu 
            660                 665                 670         


Asn Asp Thr Glu Trp Glu Lys Cys Ser Asn Ile Leu Ser Phe Tyr Arg 
        675                 680                 685             


Ser Tyr Leu Lys Ala Lys Lys Asn Phe Leu Glu Ser Leu Lys Pro Glu 
    690                 695                 700                 


Asp Trp Glu Lys Asn Gln Tyr Phe Leu Met Leu Lys Glu Pro Lys Thr 
705                 710                 715                 720 


Asn Arg Lys Thr Leu Val Gln Gly Trp Lys Asn Gly Phe Asn Leu Pro 
                725                 730                 735     


Arg Gly Ile Phe Thr Glu Pro Ile Arg Lys Trp Phe Met Glu His Trp 
            740                 745                 750         


Lys Asn Ile Lys Val Asp Asp Ser Lys Arg Val Gly Leu Val Ala Lys 
        755                 760                 765             


Val Ile Pro Leu Phe Phe Ser Glu Lys Tyr Lys Asp Ser Val Gln Pro 
    770                 775                 780                 


Phe Tyr Asn Tyr Pro Phe Asn Val Gly Asp Val Asn Lys Pro Glu Glu 
785                 790                 795                 800 


Lys Asn Phe Leu Asn Cys Glu Glu Arg Lys Gly Ile Trp Lys Glu Lys 
                805                 810                 815     


Lys Asp Lys Phe Lys Gly Tyr Lys Ala Lys Glu Lys Pro Lys Glu Met 
            820                 825                 830         


Ala Asp Lys Glu Lys Glu Glu His Arg Ser Tyr Leu Glu Phe Gln Ser 
        835                 840                 845             


Trp Asn Lys Phe Glu Arg Glu Leu Arg Leu Val Arg Asn Gln Asp Ile 
    850                 855                 860                 


Val Thr Trp Leu Leu Cys Thr Glu Leu Ile Asp Lys Leu Lys Ile Asp 
865                 870                 875                 880 


Glu Leu Asn Ile Lys Glu Leu Lys Lys Leu Arg Leu Lys Asp Ile Asn 
                885                 890                 895     


Thr Asp Thr Ala Lys Glu Glu Lys Asn Asn Ile Leu Asn Arg Val Met 
            900                 905                 910         


Pro Met Glu Leu Pro Val Thr Val Tyr Glu Val Asn Lys Gly Gly Tyr 
        915                 920                 925             


Ile Ile Lys Asn Lys Pro Leu His Thr Ile Tyr Ile Lys Glu Ala Lys 
    930                 935                 940                 


Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys Asp Arg 
945                 950                 955                 960 


Arg Leu Asn Gly Leu Phe Ser Phe Val Lys Thr Pro Ser Glu Ala Glu 
                965                 970                 975     


Ser Glu Ser Asn Pro Ile Ser Lys Leu Arg Val Glu Ser Glu Leu Gly 
            980                 985                 990         


Lys Tyr Gln Asn Ala Arg Leu Asp  Ile Ile Glu Asp Met  Leu Ala Leu 
        995                 1000                 1005             


Glu Lys  Lys Leu Ile Asp Lys  Tyr Asn Ser Leu Asp  Thr Asp Asn 
    1010                 1015                 1020             


Phe His  Asn Met Leu Thr Ala  Trp Leu Glu Leu Lys  Gly Asp Ala 
    1025                 1030                 1035             


Asn Lys  Ala Arg Phe Gln Asn  Asp Val Asp Leu Leu  Val Ala Val 
    1040                 1045                 1050             


Arg Asn  Ala Phe Ser His Asn  Gln Tyr Pro Met Tyr  Asn Glu Asn 
    1055                 1060                 1065             


Leu Phe  Gly Asn Ile Glu Arg  Phe Ser Leu Ser Ser  Ser Asn Ile 
    1070                 1075                 1080             


Ile Glu  Ser Lys Gly Leu Asp  Ile Ala Ala Lys Leu  Lys Glu Glu 
    1085                 1090                 1095             


Val Ser  Lys Ala Thr Lys Lys  Ile Gln Asn Glu Glu  Asp Asp Lys 
    1100                 1105                 1110             


Lys Glu  Lys Glu Thr 
    1115             


<210>  1945
<211>  985
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1945

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Lys His Leu 
145                 150                 155                 160 


Arg Asn Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys Gly Tyr 
                165                 170                 175     


Ala Phe Phe Ile Ser Lys Phe Leu Glu Arg Lys Tyr Ser Tyr Leu Phe 
            180                 185                 190         


Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln Tyr Arg 
        195                 200                 205             


Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro Val Glu 
    210                 215                 220                 


Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu Asp Ile 
225                 230                 235                 240 


Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr Leu Glu 
                245                 250                 255     


Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr Asp Ala 
            260                 265                 270         


Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe Arg Ser 
        275                 280                 285             


Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala Asp Phe 
    290                 295                 300                 


Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His Asn Gly 
305                 310                 315                 320 


Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr Ile Asn 
                325                 330                 335     


Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser Ala Lys 
            340                 345                 350         


Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser Thr Asp 
        355                 360                 365             


Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln Ser Thr 
    370                 375                 380                 


Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val Leu Pro 
385                 390                 395                 400 


Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala Lys Met 
                405                 410                 415     


Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala Met Leu 
            420                 425                 430         


Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His Cys Pro 
        435                 440                 445             


Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser Thr Lys 
    450                 455                 460                 


Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg Val Met 
465                 470                 475                 480 


Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu Arg Ile 
                485                 490                 495     


Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile Leu Lys 
            500                 505                 510         


Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp Leu Gln 
        515                 520                 525             


Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn Phe Gln 
    530                 535                 540                 


Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn Asp Leu 
545                 550                 555                 560 


Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn Pro His 
                565                 570                 575     


Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile Glu Phe 
            580                 585                 590         


Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg Ile Gln 
        595                 600                 605             


Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro Leu Arg 
    610                 615                 620                 


Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu Ala Ile 
625                 630                 635                 640 


Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys Leu Lys 
                645                 650                 655     


Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu Lys Ser 
            660                 665                 670         


Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg Thr Tyr 
        675                 680                 685             


Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn Tyr Arg 
    690                 695                 700                 


Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser Tyr Leu 
705                 710                 715                 720 


Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro Ser Lys 
                725                 730                 735     


Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp Arg Leu 
            740                 745                 750         


Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile Ile Arg 
        755                 760                 765             


Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys Glu Tyr 
    770                 775                 780                 


Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu Glu Asn 
785                 790                 795                 800 


Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp Leu Asn 
                805                 810                 815     


Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr Gly Lys 
            820                 825                 830         


Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn Lys Val 
        835                 840                 845             


Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val Lys Ile 
    850                 855                 860                 


Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu Glu Ala 
865                 870                 875                 880 


Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala Met Val 
                885                 890                 895     


Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr Tyr Asp 
            900                 905                 910         


Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln Lys Ile 
        915                 920                 925             


Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His Asp Lys 
    930                 935                 940                 


Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Leu Val Tyr Ala 
945                 950                 955                 960 


Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile Lys Leu 
                965                 970                 975     


Glu Asp Leu Ser Asn Asp Ser Ser Ala 
            980                 985 


<210>  1946
<211>  1200
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1946

Met Gln Glu Glu Ile Ile Ser Ala Asp Pro Lys Thr Lys Gln Thr Lys 
1               5                   10                  15      


Phe Asn His Tyr Ser Glu Glu Asp Lys Tyr Phe Phe Gly Gly Phe Leu 
            20                  25                  30          


Asn Asn Ala Asp Asp Asn Leu Lys Gln Val Ser Lys Glu Phe Lys Glu 
        35                  40                  45              


Arg Leu Asn Ile Ile Gly Gln Asn Glu Asn Thr Ser Thr Ser Asn Asp 
    50                  55                  60                  


Asp Asp Asn Leu Asn Ser Val Val Lys Gln Tyr Ile Asn Asn Asn Lys 
65                  70                  75                  80  


Ser Leu Ala Lys Lys Glu Lys Ala Ile Asn Ile Leu Ile Asp Tyr Phe 
                85                  90                  95      


Pro Ile Val Ala Ala Val Lys Lys Tyr Cys Ser Asn Asn Ile Asp Glu 
            100                 105                 110         


Thr Phe Glu Leu Phe Lys Leu Leu Leu Gly Thr Val Ala Asp Leu Arg 
        115                 120                 125             


Asn Phe Tyr Thr His Tyr Tyr His Lys Pro Ile Thr Ile Asp Glu Lys 
    130                 135                 140                 


Val Tyr Asp Phe Leu Asp Thr Thr Leu Phe Asp Val Phe Met Thr Ile 
145                 150                 155                 160 


Lys Lys Lys Lys Val Lys Asn Asp Lys Ser Lys Glu Leu Leu Lys Glu 
                165                 170                 175     


Lys Leu Arg Pro Glu Leu Lys Leu Leu Ile Asn Leu Lys Arg Lys Glu 
            180                 185                 190         


Leu Ile Gln Lys Gly Lys Lys Thr Glu Asn Leu Glu Asn Ala Val Phe 
        195                 200                 205             


Asn His Cys Leu Arg Pro Phe Leu Glu Glu Thr Lys Asn Ser Lys Asn 
    210                 215                 220                 


Lys Thr Ile Ser Leu Arg Ser Tyr Lys Lys Ser Lys Pro Glu Glu Glu 
225                 230                 235                 240 


Thr Thr Val Pro Ile Thr Gln Ser Gly Leu Val Phe Leu Met Ser Phe 
                245                 250                 255     


Phe Leu His Arg Lys Asp Phe Gln Leu Phe Ile Ser Gly Leu Glu Gly 
            260                 265                 270         


Phe Lys Gly Lys Val Asn Ala Val Gln Glu Glu Glu Ile Thr Leu Lys 
        275                 280                 285             


Lys Asn Asn Leu Val Tyr Met Ile Ser His Trp Ser Tyr Ser Tyr Tyr 
    290                 295                 300                 


Asn Phe Lys Gly Leu Lys His Arg Ile Lys Thr Asp Gln Gly Val Asn 
305                 310                 315                 320 


Glu Ile Glu Tyr Asp Gly Ile Thr His Thr Ile Thr Asn Lys Asp Thr 
                325                 330                 335     


Lys Glu Ala Leu Leu Thr Gln Leu Val Asp Tyr Leu Ser Lys Val Pro 
            340                 345                 350         


Asp Glu Val Tyr Asn Asn Leu Ser Glu Glu Gln Gln Asn Glu Phe Leu 
        355                 360                 365             


Glu Asp Val Asn Glu Tyr Met Arg Asp Asn Pro Glu Asn Glu Asp Ser 
    370                 375                 380                 


Ser Ile Ser Ser Ile Val Ser His Gln Val Ile Arg Lys Arg Tyr Glu 
385                 390                 395                 400 


Asn Lys Phe Asn Tyr Phe Ala Leu Arg Phe Ile Asp Glu Tyr Gly Asn 
                405                 410                 415     


Leu Pro Ser Phe Arg Phe Met Val Asn Phe Gly Ser Tyr Ile Lys Asp 
            420                 425                 430         


Arg Lys Lys Lys Val Leu Asp Ser Ile Asn Tyr Asn Ser Glu Arg Ile 
        435                 440                 445             


Ile Lys Lys Glu Ile His Leu Phe Glu Lys Leu Ser Met Val Thr Asp 
    450                 455                 460                 


Tyr Lys Lys Asn Leu Phe Leu Asn Glu Thr Ala Thr Leu Asn Leu Ala 
465                 470                 475                 480 


Gln Phe Pro Leu Phe Pro Asn Pro Ser Tyr Val Ile Ala Asn Asn Asn 
                485                 490                 495     


Ile Pro Phe Tyr Ile Asn Cys Gln Lys Asn Asp Leu Asn Asp Tyr Phe 
            500                 505                 510         


Gly Lys Lys Lys Ser Ser Gln Ser Gln Asn Gln Lys Lys Asn His Thr 
        515                 520                 525             


Tyr Asp Lys Asp Asn Lys Gly Gln Thr Ser Ser Asn Ile Val Gly Glu 
    530                 535                 540                 


Leu Glu Lys Ala Leu Gly Val Lys Asp Ile Lys Gln Arg Ser Thr Ile 
545                 550                 555                 560 


Gly Leu Phe Ser Cys Asn Glu Leu Ser Ser Met Leu His Glu Ile Ile 
                565                 570                 575     


Val Lys Lys Thr Ser Gly Val Asp Leu Glu Asn Arg Ile Ala Gln Lys 
            580                 585                 590         


Ile Lys Glu Gln Tyr Gln Ile Ile Lys Asp Phe Asp Ser Asn Ser Tyr 
        595                 600                 605             


Asp Glu Ser Ala Lys Asn Lys Ile Pro Lys Ala Leu Leu Lys Thr Ser 
    610                 615                 620                 


Lys Val Asp Ser Thr Ile Thr Phe Glu Gly Lys Gln Ile Asp Leu Ala 
625                 630                 635                 640 


Arg Leu Ile Asn Ala Val Thr Phe Glu Leu Asp Ala Thr His Ala Lys 
                645                 650                 655     


Ile Lys Thr Val Lys Glu Arg Glu Glu Glu Val Arg Lys Gly Glu Ile 
            660                 665                 670         


Glu Lys Asn Gln Lys Asn Ser Ser Asn Lys Gln Lys Thr Lys Val Lys 
        675                 680                 685             


Tyr Arg Lys Tyr Val Phe Tyr Asn Asn Glu Ile Gly Gln Glu Ala Ser 
    690                 695                 700                 


Trp Leu Ala Gly Asp Leu Ile Arg Tyr Met Lys Asn Asn Ala Thr Trp 
705                 710                 715                 720 


Lys Gly Tyr Met His Ser Glu Leu Gln Ala Leu Leu Ala Phe Tyr Glu 
                725                 730                 735     


Glu Lys Arg Asn Asp Ile Ile Thr Ile Leu Glu Asn Thr Phe Asn Leu 
            740                 745                 750         


Lys Ala Asp Cys Leu Leu Thr Ile Asp Leu Lys Ser Leu Leu Val Lys 
        755                 760                 765             


Asn His Lys Phe Ile Asp Phe Tyr Lys Asp Tyr Leu Ser Leu Lys Arg 
    770                 775                 780                 


Ser Phe Leu Asn Glu Lys Leu Met Phe Leu Lys Asn Asn Asp Phe Asn 
785                 790                 795                 800 


Gly Ile Pro Ala Lys Thr Leu Lys Lys Glu Trp Asn Ser Val Phe Glu 
                805                 810                 815     


Val Phe Lys Lys Arg Gln Tyr Leu Ile Gln Ser Thr Glu Glu Lys Lys 
            820                 825                 830         


Gln Asn Leu Tyr Gly Asp Ala Ile Asn Leu Ser Arg Gly Ile Phe Asp 
        835                 840                 845             


Asp Lys Pro Thr Met Ile Pro Asn Lys Gln Pro Asn Arg Glu Glu Phe 
    850                 855                 860                 


Ala Ala Trp Phe Val Ala Pro Thr Val Tyr Glu His Tyr Gln Ser Phe 
865                 870                 875                 880 


Tyr Asn Leu Ile Asp Leu Asn Asn Pro Lys Thr Asp Thr Lys Glu Gln 
                885                 890                 895     


Thr Lys Gln Asn Tyr Lys Thr Ile Arg Thr Leu Asn Lys Ile Lys Ile 
            900                 905                 910         


Gln Asp Tyr Tyr Leu Lys Leu Met Val Asp Ala Leu Tyr Lys Asp Leu 
        915                 920                 925             


Phe Gly Gln Glu Leu Asn Ile Glu Leu Lys Asp Phe Tyr Val Pro Lys 
    930                 935                 940                 


Ser Glu Arg Glu Ser Ile Lys Ala Asp Ala Lys Asn Tyr Gln Gln Val 
945                 950                 955                 960 


Asp Asn Ser Phe Leu Trp Asn Lys Val Val His His Thr Leu Gln Gly 
                965                 970                 975     


Gly Arg Ile Asn Ala Thr Ala Lys Leu Lys Asp Ile Gly Lys Tyr Lys 
            980                 985                 990         


Arg Ala Met Lys Asp Glu Lys Ile  Ala Ser Leu Leu Thr  Tyr Asp Asp 
        995                 1000                 1005             


Arg Thr  Trp Thr Tyr Ala Leu  Asp Asn Ile Lys Asp  Glu Ser Lys 
    1010                 1015                 1020             


Gln Thr  His Leu Tyr Ser Leu  Thr Met Glu Leu Gln  Glu Tyr Glu 
    1025                 1030                 1035             


Lys Val  Arg Ser Lys Glu Leu  Leu Lys Gln Val Gln  Gln Leu Glu 
    1040                 1045                 1050             


Lys Glu  Ile Leu Asn Leu Asp  Glu Asp Phe Val Thr  Thr Gln Asn 
    1055                 1060                 1065             


His Pro  Ile Ile Phe Glu Val  Ala Asn Asn Pro Arg  Phe Arg Lys 
    1070                 1075                 1080             


Tyr Ile  Glu Glu Gly Ile Leu  Asn Lys Ile Leu Pro  Asn Glu Asn 
    1085                 1090                 1095             


Gln Val  Glu Ile Leu Arg Gly  Ile Asp Phe Asp Asp  Leu Ser Trp 
    1100                 1105                 1110             


Ala Phe  Asp Ser Ser Glu Arg  Asn Glu Glu Gln Lys  Glu Lys Ile 
    1115                 1120                 1125             


Asn Leu  Tyr Tyr Gln Ile Thr  Asn Pro Gln Val Gln  Arg Gly Leu 
    1130                 1135                 1140             


Ile Leu  Ile Met Ile Arg Asn  Lys Ile Ala His Asn  Gln Tyr Pro 
    1145                 1150                 1155             


Pro Lys  Tyr Ile Tyr Asp Leu  Ala Gln Thr Phe Ile  Pro Lys Lys 
    1160                 1165                 1170             


Glu Asn  Glu Tyr Phe Ala Ser  Tyr Phe Asn Arg Val  Phe Lys Glu 
    1175                 1180                 1185             


Met Thr  Lys Lys Leu Leu Glu  Ser Leu Glu Lys Lys  
    1190                 1195                 1200 


<210>  1947
<211>  1125
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1947

Met Glu Asp Asp Lys Lys Thr Lys Glu Ser Thr Asn Met Leu Asp Asn 
1               5                   10                  15      


Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val Tyr 
            20                  25                  30          


Ile Thr Val Asn His Ile Asn Lys Val Leu Glu Leu Lys Asn Lys Lys 
        35                  40                  45              


Asp Gln Asp Ile Ile Ile Asp Asn Asp Gln Asp Ile Leu Ala Ile Lys 
    50                  55                  60                  


Thr His Trp Glu Lys Val Asp Gly Asp Leu Asn Lys Thr Glu Arg Leu 
65                  70                  75                  80  


Arg Glu Leu Met Thr Lys His Phe Pro Phe Leu Glu Thr Ala Ile Tyr 
                85                  90                  95      


Thr Lys Asn Lys Glu Asp Lys Glu Glu Val Lys Gln Glu Lys Gln Ala 
            100                 105                 110         


Lys Ala Gln Ser Phe Asp Ser Leu Lys His Cys Leu Phe Leu Phe Leu 
        115                 120                 125             


Glu Lys Leu Gln Glu Ala Arg Asn Tyr Tyr Ser His Tyr Lys Tyr Ser 
    130                 135                 140                 


Glu Ser Thr Lys Glu Pro Met Leu Glu Lys Glu Leu Leu Lys Lys Met 
145                 150                 155                 160 


Tyr Asn Ile Phe Asp Asp Asn Ile Gln Leu Val Ile Lys Asp Tyr Gln 
                165                 170                 175     


His Asn Lys Asp Ile Asn Pro Asp Glu Asp Phe Lys His Leu Asp Arg 
            180                 185                 190         


Thr Glu Glu Glu Phe Asn Tyr Tyr Phe Thr Arg Asn Lys Lys Gly Asn 
        195                 200                 205             


Ile Thr Ala Ser Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys 
    210                 215                 220                 


Lys Asp Ala Ile Trp Met Gln Gln Lys Leu Arg Gly Phe Lys Asp Asn 
225                 230                 235                 240 


Arg Glu Ser Lys Lys Lys Met Thr His Glu Val Phe Cys Arg Ser Arg 
                245                 250                 255     


Met Leu Leu Pro Lys Leu Arg Leu Glu Ser Thr Gln Thr Gln Asp Trp 
            260                 265                 270         


Ile Leu Leu Asp Met Leu Asn Glu Leu Ile Arg Cys Pro Lys Ser Leu 
        275                 280                 285             


Tyr Glu Arg Leu Gln Gly Glu Asp Arg Glu Lys Phe Lys Val Pro Phe 
    290                 295                 300                 


Asp Pro Ala Asp Glu Asp Tyr Asp Ala Glu Gln Glu Pro Phe Lys Asn 
305                 310                 315                 320 


Thr Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr 
                325                 330                 335     


Phe Asp Tyr Asn Glu Ile Phe Thr Asn Leu Arg Phe Gln Ile Asp Leu 
            340                 345                 350         


Gly Thr Tyr His Phe Ser Ile Tyr Lys Lys Leu Ile Gly Gly Gln Lys 
        355                 360                 365             


Glu Asp Arg His Leu Thr His Lys Leu Tyr Gly Phe Glu Arg Ile Gln 
    370                 375                 380                 


Glu Phe Ala Lys Gln Asn Arg Pro Asp Glu Trp Lys Ala Ile Val Lys 
385                 390                 395                 400 


Asp Leu Asp Thr Tyr Glu Thr Ser Asn Glu Arg Tyr Ile Ser Glu Thr 
                405                 410                 415     


Thr Pro His Tyr His Leu Glu Asn Gln Lys Ile Gly Ile Arg Phe Arg 
            420                 425                 430         


Asn Gly Asn Lys Glu Ile Trp Pro Ser Leu Glu Thr Asn Gly Glu Asn 
        435                 440                 445             


Asn Glu Lys Arg Lys Tyr Lys Leu Asp Lys Gln Tyr Gln Ala Glu Ala 
    450                 455                 460                 


Phe Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu 
465                 470                 475                 480 


Leu Lys Lys Glu Glu Pro Asn Asn Asp Lys Lys Asn Ala Ser Ile Val 
                485                 490                 495     


Glu Gly Phe Ile Lys Arg Glu Ile Arg Asp Ile Tyr Lys Leu Tyr Asp 
            500                 505                 510         


Ala Phe Ala Asn Gly Glu Ile Asn Asn Ile Asp Asp Leu Glu Lys Tyr 
        515                 520                 525             


Cys Glu Asp Lys Gly Ile Pro Lys Arg His Leu Pro Lys Gln Met Val 
    530                 535                 540                 


Ala Ile Leu Tyr Asp Glu His Lys Asp Met Val Lys Glu Ala Lys Arg 
545                 550                 555                 560 


Lys Gln Lys Glu Met Val Lys Asp Thr Lys Lys Leu Leu Ala Thr Leu 
                565                 570                 575     


Glu Lys Gln Thr Gln Gly Glu Ile Glu Asp Gly Gly Arg Asn Ile Arg 
            580                 585                 590         


Leu Leu Lys Ser Gly Glu Ile Ala Arg Trp Leu Val Asn Asp Met Met 
        595                 600                 605             


Arg Phe Gln Pro Val Gln Lys Asp Asn Glu Gly Asn Pro Leu Asn Asn 
    610                 615                 620                 


Ser Lys Ala Asn Ser Thr Glu Tyr Gln Met Leu Gln Arg Ser Leu Ala 
625                 630                 635                 640 


Leu Tyr Asn Lys Glu Glu Lys Pro Thr Arg Tyr Phe Arg Gln Val Asn 
                645                 650                 655     


Leu Ile Asn Ser Ser Asn Pro His Pro Phe Leu Lys Trp Thr Lys Trp 
            660                 665                 670         


Glu Glu Cys Asn Asn Ile Leu Ser Phe Tyr Arg Ser Tyr Leu Thr Lys 
        675                 680                 685             


Lys Ile Glu Phe Leu Asn Lys Leu Lys Pro Glu Asp Trp Glu Lys Asn 
    690                 695                 700                 


Gln Tyr Phe Leu Lys Leu Lys Glu Pro Lys Thr Asn Arg Glu Thr Leu 
705                 710                 715                 720 


Val Gln Gly Trp Lys Asn Gly Phe Asn Leu Pro Arg Gly Ile Phe Thr 
                725                 730                 735     


Glu Pro Ile Arg Glu Trp Phe Lys Arg His Gln Asn Asn Ser Glu Glu 
            740                 745                 750         


Tyr Glu Lys Val Glu Ala Leu Asp Arg Val Gly Leu Val Thr Lys Val 
        755                 760                 765             


Ile Pro Leu Phe Phe Lys Glu Glu Tyr Phe Lys Glu Asp Ala Gln Lys 
    770                 775                 780                 


Glu Ile Asn Asn Cys Val Gln Pro Phe Tyr Ser Phe Pro Tyr Asn Val 
785                 790                 795                 800 


Gly Asn Ile His Lys Pro Asp Glu Lys Asp Phe Leu Pro Ser Glu Glu 
                805                 810                 815     


Arg Lys Lys Leu Trp Gly Asp Lys Lys Asp Lys Phe Lys Gly Tyr Lys 
            820                 825                 830         


Ala Lys Val Lys Ser Lys Lys Leu Thr Asp Lys Glu Lys Glu Glu Tyr 
        835                 840                 845             


Arg Ser Tyr Leu Glu Phe Gln Ser Trp Asn Lys Phe Glu Arg Glu Leu 
    850                 855                 860                 


Arg Leu Val Arg Asn Gln Asp Ile Val Thr Trp Leu Leu Cys Thr Glu 
865                 870                 875                 880 


Leu Ile Asp Lys Leu Lys Val Glu Gly Leu Asn Val Glu Glu Leu Gln 
                885                 890                 895     


Lys Leu Arg Leu Lys Asp Ile Asp Thr Asp Thr Ala Lys Gln Glu Lys 
            900                 905                 910         


Asn Asn Ile Leu Asn Arg Ile Met Pro Met Gln Leu Pro Val Thr Val 
        915                 920                 925             


Tyr Glu Ile Asp Asp Ser His Lys Ile Val Lys Asp Arg Pro Leu His 
    930                 935                 940                 


Thr Val Tyr Ile Glu Glu Thr Lys Thr Lys Leu Leu Lys Gln Gly Asn 
945                 950                 955                 960 


Phe Lys Ala Leu Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe 
                965                 970                 975     


Val Asp Thr Ser Ser Glu Ala Glu Leu Lys Asp Lys Pro Ile Ser Lys 
            980                 985                 990         


Ser Val Val Glu Tyr Glu Leu Gly  Glu Tyr Gln Asn Ala  Arg Ile Glu 
        995                 1000                 1005             


Thr Ile  Lys Asp Met Leu Leu  Leu Glu Glu Thr Leu  Ile Lys Lys 
    1010                 1015                 1020             


Tyr Lys  Thr Leu Pro Thr Asn  Lys Phe Lys Lys Met  Leu Lys Gly 
    1025                 1030                 1035             


Trp Leu  Glu Gly Lys Asp Glu  Ala Asp Lys Ala Arg  Phe Gln Asn 
    1040                 1045                 1050             


Asp Val  Lys Leu Leu Val Ala  Val Arg Asn Ala Phe  Ser His Asn 
    1055                 1060                 1065             


Gln Tyr  Pro Met Arg Asn Arg  Ile Ala Phe Ala Asn  Ile Asn Pro 
    1070                 1075                 1080             


Phe Ser  Leu Ser Ser Ala Asn  Thr Ser Glu Glu Lys  Gly Leu Gly 
    1085                 1090                 1095             


Ile Ala  Asn Gln Leu Lys Asp  Lys Thr Lys Glu Thr  Ile Glu Lys 
    1100                 1105                 1110             


Ile Ile  Lys Ile Glu Lys Pro  Ile Glu Thr Lys Glu  
    1115                 1120                 1125 


<210>  1948
<211>  985
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1948

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Asn Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys Gly Tyr 
                165                 170                 175     


Ala Phe Phe Ile Ser Lys Phe Leu Glu Arg Lys Tyr Ser Tyr Leu Phe 
            180                 185                 190         


Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln Tyr Arg 
        195                 200                 205             


Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro Val Glu 
    210                 215                 220                 


Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu Asp Ile 
225                 230                 235                 240 


Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr Leu Glu 
                245                 250                 255     


Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr Asp Ala 
            260                 265                 270         


Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe Arg Ser 
        275                 280                 285             


Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala Asp Phe 
    290                 295                 300                 


Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His Asn Gly 
305                 310                 315                 320 


Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr Ile Asn 
                325                 330                 335     


Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser Ala Lys 
            340                 345                 350         


Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser Thr Asp 
        355                 360                 365             


Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln Ser Thr 
    370                 375                 380                 


Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val Leu Pro 
385                 390                 395                 400 


Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala Lys Met 
                405                 410                 415     


Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala Met Leu 
            420                 425                 430         


Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His Cys Pro 
        435                 440                 445             


Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser Thr Lys 
    450                 455                 460                 


Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg Val Met 
465                 470                 475                 480 


Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu Arg Ile 
                485                 490                 495     


Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile Leu Lys 
            500                 505                 510         


Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp Leu Gln 
        515                 520                 525             


Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn Phe Gln 
    530                 535                 540                 


Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn Asp Leu 
545                 550                 555                 560 


Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn Pro His 
                565                 570                 575     


Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile Glu Phe 
            580                 585                 590         


Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg Ile Gln 
        595                 600                 605             


Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro Leu Arg 
    610                 615                 620                 


Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu Ala Ile 
625                 630                 635                 640 


Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys Leu Lys 
                645                 650                 655     


Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu Lys Ser 
            660                 665                 670         


Pro Ala Leu Asn Val Ser Tyr Leu Ile His Asn Tyr Phe Arg Ala Tyr 
        675                 680                 685             


Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn Tyr Arg 
    690                 695                 700                 


Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser Tyr Leu 
705                 710                 715                 720 


Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro Ser Lys 
                725                 730                 735     


Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp Arg Leu 
            740                 745                 750         


Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile Ile Arg 
        755                 760                 765             


Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys Glu Tyr 
    770                 775                 780                 


Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu Glu Asn 
785                 790                 795                 800 


Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp Leu Asn 
                805                 810                 815     


Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr Gly Lys 
            820                 825                 830         


Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn Lys Val 
        835                 840                 845             


Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val Lys Ile 
    850                 855                 860                 


Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu Glu Ala 
865                 870                 875                 880 


Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala Met Val 
                885                 890                 895     


Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr Tyr Asp 
            900                 905                 910         


Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln Lys Ile 
        915                 920                 925             


Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His Asp Lys 
    930                 935                 940                 


Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val Tyr Ala 
945                 950                 955                 960 


Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile Lys Leu 
                965                 970                 975     


Glu Asp Leu Ser Asn Asp Ser Ser Ala 
            980                 985 


<210>  1949
<211>  1125
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1949

Met Glu Asp Asp Lys Lys Thr Lys Glu Ser Thr Asn Met Leu Asp Asn 
1               5                   10                  15      


Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val Tyr 
            20                  25                  30          


Ile Thr Val Asn His Ile Asn Lys Val Leu Glu Leu Lys Asn Lys Lys 
        35                  40                  45              


Asp Gln Asp Ile Ile Ile Asp Asn Asp Gln Asp Ile Leu Ala Ile Lys 
    50                  55                  60                  


Thr His Trp Glu Lys Val Asp Gly Asp Leu Asn Lys Thr Glu Arg Leu 
65                  70                  75                  80  


Arg Glu Leu Met Thr Lys His Phe Pro Phe Leu Glu Thr Ala Ile Tyr 
                85                  90                  95      


Thr Lys Asn Lys Glu Asp Lys Glu Glu Val Lys Gln Glu Lys Gln Ala 
            100                 105                 110         


Lys Ala Gln Ser Phe Asp Ser Leu Lys His Cys Leu Phe Leu Phe Leu 
        115                 120                 125             


Glu Lys Leu Gln Glu Ala Arg Asn Tyr Tyr Ser His Tyr Lys Tyr Ser 
    130                 135                 140                 


Glu Ser Thr Lys Glu Pro Met Leu Glu Lys Glu Leu Leu Lys Lys Met 
145                 150                 155                 160 


Tyr Asn Ile Phe Asp Asp Asn Ile Gln Leu Val Ile Lys Asp Tyr Gln 
                165                 170                 175     


His Asn Lys Asp Ile Asn Pro Asp Glu Asp Phe Lys His Leu Asp Arg 
            180                 185                 190         


Thr Glu Glu Glu Phe Asn Tyr Tyr Phe Thr Arg Asn Lys Lys Gly Asn 
        195                 200                 205             


Ile Thr Ala Ser Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys 
    210                 215                 220                 


Lys Asp Ala Ile Trp Met Gln Gln Lys Leu Arg Gly Phe Lys Asp Asn 
225                 230                 235                 240 


Arg Glu Ser Lys Lys Lys Met Thr His Glu Val Phe Cys Arg Ser Arg 
                245                 250                 255     


Met Leu Leu Pro Lys Leu Arg Leu Glu Ser Thr Gln Thr Gln Asp Trp 
            260                 265                 270         


Ile Leu Leu Asp Met Leu Asn Glu Leu Ile Arg Cys Pro Lys Ser Leu 
        275                 280                 285             


Tyr Glu Arg Leu Gln Gly Glu Asp Arg Glu Lys Phe Lys Val Pro Phe 
    290                 295                 300                 


Asp Pro Ala Asp Glu Asp Tyr Asp Ala Glu Gln Glu Pro Phe Lys Asn 
305                 310                 315                 320 


Thr Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr 
                325                 330                 335     


Phe Asp Tyr Asn Glu Ile Phe Thr Asn Leu Arg Phe Gln Ile Asp Leu 
            340                 345                 350         


Gly Thr Tyr His Phe Ser Ile Tyr Lys Lys Leu Ile Gly Gly Gln Lys 
        355                 360                 365             


Glu Asp Arg His Leu Thr His Lys Leu Tyr Gly Phe Glu Arg Ile Gln 
    370                 375                 380                 


Glu Phe Ala Lys Gln Asn Arg Pro Asp Glu Trp Lys Ala Ile Val Lys 
385                 390                 395                 400 


Asp Leu Asp Thr Tyr Glu Thr Ser Asn Glu Arg Tyr Ile Ser Glu Thr 
                405                 410                 415     


Thr Pro His Tyr His Leu Glu Asn Gln Lys Ile Gly Ile Arg Phe Arg 
            420                 425                 430         


Asn Gly Asn Lys Glu Ile Trp Pro Ser Leu Glu Thr Asn Gly Glu Asn 
        435                 440                 445             


Asn Glu Lys Arg Lys Tyr Lys Leu Asp Lys Gln Tyr Gln Ala Glu Ala 
    450                 455                 460                 


Phe Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu 
465                 470                 475                 480 


Leu Lys Lys Glu Glu Pro Asn Asn Asp Lys Lys Asn Ala Ser Ile Val 
                485                 490                 495     


Glu Gly Phe Ile Lys Arg Glu Ile Arg Asp Ile Tyr Lys Leu Tyr Asp 
            500                 505                 510         


Ala Phe Ala Asn Gly Glu Ile Asn Asn Ile Asp Asp Leu Glu Lys Tyr 
        515                 520                 525             


Cys Glu Asp Lys Gly Ile Pro Lys Arg His Leu Pro Lys Gln Met Val 
    530                 535                 540                 


Ala Ile Leu Tyr Asp Glu His Lys Asp Met Val Lys Glu Ala Lys Arg 
545                 550                 555                 560 


Lys Gln Lys Glu Met Val Lys Asp Thr Lys Lys Leu Leu Ala Thr Leu 
                565                 570                 575     


Glu Lys Gln Thr Gln Gly Glu Ile Glu Asp Gly Gly Arg Asn Ile Arg 
            580                 585                 590         


Leu Leu Lys Ser Gly Glu Ile Ala Arg Trp Leu Val Asn Asp Met Met 
        595                 600                 605             


Arg Phe Gln Pro Val Gln Lys Asp Asn Glu Gly Asn Pro Leu Asn Asn 
    610                 615                 620                 


Ser Lys Ala Asn Ser Thr Glu Tyr Gln Met Leu Gln Arg Ser Leu Ala 
625                 630                 635                 640 


Leu Tyr Asn Lys Glu Glu Lys Pro Thr Arg Tyr Phe Arg Gln Val Asn 
                645                 650                 655     


Leu Ile Asn Ser Ser Asn Pro His Pro Phe Leu Lys Trp Thr Lys Trp 
            660                 665                 670         


Glu Glu Cys Asn Asn Ile Leu Ser Phe Tyr Arg Ser Tyr Leu Thr Lys 
        675                 680                 685             


Lys Ile Glu Phe Leu Asn Lys Leu Lys Pro Glu Asp Trp Glu Lys Asn 
    690                 695                 700                 


Gln Tyr Phe Leu Lys Leu Lys Glu Pro Lys Thr Asn Arg Glu Thr Leu 
705                 710                 715                 720 


Val Gln Gly Trp Lys Asn Gly Phe Asn Leu Pro Arg Gly Ile Phe Thr 
                725                 730                 735     


Glu Pro Ile Arg Glu Trp Phe Lys Arg His Gln Asn Asn Ser Glu Glu 
            740                 745                 750         


Tyr Glu Lys Val Glu Ala Leu Asp Arg Val Gly Leu Val Thr Lys Val 
        755                 760                 765             


Ile Pro Leu Phe Phe Lys Glu Glu Tyr Phe Lys Glu Asp Ala Gln Lys 
    770                 775                 780                 


Glu Ile Asn Asn Cys Val Gln Pro Phe Tyr Ser Phe Pro Tyr Asn Val 
785                 790                 795                 800 


Gly Asn Ile His Lys Pro Asp Glu Lys Asp Phe Leu Pro Ser Glu Glu 
                805                 810                 815     


Arg Lys Lys Leu Trp Gly Asp Lys Lys Asp Lys Phe Lys Gly Tyr Lys 
            820                 825                 830         


Ala Lys Val Lys Ser Lys Lys Leu Thr Asp Lys Glu Lys Glu Glu Tyr 
        835                 840                 845             


Arg Ser Tyr Leu Glu Phe Gln Ser Trp Asn Lys Phe Glu Arg Glu Leu 
    850                 855                 860                 


Arg Leu Val Arg Asn Gln Asp Ile Val Thr Trp Leu Leu Cys Thr Glu 
865                 870                 875                 880 


Leu Ile Asp Lys Leu Lys Val Glu Gly Leu Asn Val Glu Glu Leu Gln 
                885                 890                 895     


Lys Leu Arg Leu Lys Asp Ile Asp Thr Asp Thr Ala Lys Gln Glu Lys 
            900                 905                 910         


Asn Asn Ile Leu Asn Arg Ile Met Pro Met Gln Leu Pro Val Thr Val 
        915                 920                 925             


Tyr Glu Ile Asp Asp Ser His Lys Ile Val Lys Asp Arg Pro Leu His 
    930                 935                 940                 


Thr Val Tyr Ile Glu Glu Thr Lys Thr Lys Leu Leu Lys Gln Gly Asn 
945                 950                 955                 960 


Phe Lys Ala Leu Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe 
                965                 970                 975     


Val Asp Thr Ser Ser Glu Ala Glu Leu Lys Asp Lys Pro Ile Ser Lys 
            980                 985                 990         


Ser Val Val Glu Tyr Glu Leu Gly  Glu Tyr Gln Asn Ala  Arg Ile Glu 
        995                 1000                 1005             


Thr Ile  Lys Asp Met Leu Leu  Leu Glu Glu Thr Leu  Ile Lys Lys 
    1010                 1015                 1020             


Tyr Lys  Thr Leu Pro Thr Asn  Lys Phe Lys Lys Met  Leu Lys Gly 
    1025                 1030                 1035             


Trp Leu  Glu Gly Lys Asp Glu  Ala Asp Lys Ala Arg  Phe Gln Asn 
    1040                 1045                 1050             


Asp Val  Lys Leu Leu Val Ala  Val Arg Asn Ala Phe  Ser His Asn 
    1055                 1060                 1065             


Gln Tyr  Pro Met Arg Asn Arg  Ile Ala Phe Ala Asn  Ile Asn Pro 
    1070                 1075                 1080             


Phe Ser  Leu Ser Ser Ala Asn  Thr Ser Glu Glu Lys  Gly Leu Gly 
    1085                 1090                 1095             


Ile Ala  Asn Gln Leu Lys Asp  Lys Thr Lys Glu Thr  Ile Glu Lys 
    1100                 1105                 1110             


Ile Ile  Lys Ile Glu Lys Pro  Ile Glu Thr Lys Glu  
    1115                 1120                 1125 


<210>  1950
<211>  1104
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1950

Met Gln Asp Lys Leu Asn Asp Asn Val Ser Thr Ala Arg Thr Ile Ser 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn Tyr Ile Gly Gln Leu Phe Asn Gln Ser Leu 
        35                  40                  45              


Leu Pro Glu Glu Ala His Ile Pro Asn Ser Phe Leu Thr Asn Tyr Gln 
    50                  55                  60                  


Ile Lys His Leu Asn Trp Asn His Thr Tyr Ser Arg Thr Leu Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Val Lys Leu Phe Asn Leu Glu Glu Tyr Pro Lys Asn Thr 
                85                  90                  95      


Asn Gly Lys Leu Asp His Thr Leu Ile Thr Pro Gly Leu Thr Lys Asp 
            100                 105                 110         


Phe Glu Ser Met Ser Lys Tyr Leu Lys Gln Val Phe Ala Asp Ile Asn 
        115                 120                 125             


Asp Phe Arg Asn Asp Tyr Ser His Phe Tyr Ser Thr Thr Thr Gly Thr 
    130                 135                 140                 


Asn Arg Lys Leu Tyr Val Asp Asp Gln Thr Ala Thr Leu Leu Thr Asn 
145                 150                 155                 160 


Ala Phe Glu Phe Ala Ile Asp His Thr Met Leu Arg Leu Lys Gly Val 
                165                 170                 175     


Leu Ser Glu Glu Asp Phe Asn His Val Arg Ile Arg Lys Ile Val Glu 
            180                 185                 190         


Ala Asp Asn Lys Ile Thr Thr Asp Gly Leu Val Phe Leu Ile Cys Met 
        195                 200                 205             


Phe Leu Glu Arg Glu His Ala Phe Gln Phe Ile Asn Arg Val Lys Gly 
    210                 215                 220                 


Phe Lys Gly Thr Gln Tyr Cys Cys Phe Val Ala Thr Arg Glu Val Phe 
225                 230                 235                 240 


Met Thr Phe Cys Val Lys Leu Pro His Asp Lys Phe Ile Ser Ser Asp 
                245                 250                 255     


Ile Lys Gln Arg Leu Ile Met Asn Met Ile Asn Glu Leu Asn Asn Cys 
            260                 265                 270         


Pro Lys Asp Leu Tyr Ala Val Leu Ser Glu Lys Glu Arg Glu Lys Val 
        275                 280                 285             


Arg Ser Ile Asp Val Thr Asn Asn Gly Ser Asp Asp Asn Phe Gly Glu 
    290                 295                 300                 


Met Asp Tyr Asp Leu Tyr Lys Glu Glu Leu Ile Ser Asn Ile Arg His 
305                 310                 315                 320 


Ser Asn Arg Phe Pro Tyr Phe Ala Leu Gly Phe Ile Asp Glu Thr Gly 
                325                 330                 335     


Cys Leu Ser Ser Trp Arg Phe His Ile Asn Ile Gly Lys Leu Glu Leu 
            340                 345                 350         


Ala Ser Tyr Phe Lys Pro Leu Ala Gly Ser Glu Glu Gln Arg Arg Ile 
        355                 360                 365             


Ile Glu Asn Val Lys Ala Phe Gly Lys Leu Ser Asp Phe Asn Asp Lys 
    370                 375                 380                 


Asp Ser Thr Tyr Thr Lys Ile Asn Asn Lys Leu His Asp His Gly Phe 
385                 390                 395                 400 


Asp Gln Phe Ala Pro His Tyr Asn Ile Ile Gln Asn Lys Ile Gly Ile 
                405                 410                 415     


Tyr Arg Thr Thr Leu Lys Thr Pro Ile Ile Ile Arg Arg Ser Gly Gln 
            420                 425                 430         


Thr Asp Asn Leu Lys Val Arg Ile Lys Gln His Ala Pro Glu Ala Phe 
        435                 440                 445             


Leu Ser Leu His Met Leu Pro Gln Ile Ile Leu Leu Glu Tyr Leu Lys 
    450                 455                 460                 


Ser Gly Ala Ala Glu Lys Ile Leu Asn His Phe Ile Asp Phe Asn Gln 
465                 470                 475                 480 


Glu Ile Leu Asn Glu Lys Phe Ile Arg Lys Ile Lys Glu Lys Leu Pro 
                485                 490                 495     


Ser Asp Trp Ser Glu Phe His Arg Lys Thr Asp Ser Lys Lys Gln Ser 
            500                 505                 510         


Ala Tyr Ser Ala Lys Ser Leu Asn Cys Leu Glu Asp Arg Lys Gln Cys 
        515                 520                 525             


Leu Asn Asn Val Leu Asp His Tyr Asn Leu Asn Ile Lys Gln Ile Pro 
    530                 535                 540                 


Ser Arg Ile Ile Asp Tyr Trp Leu Asn Ile Ala Asp Val Asp Asp Ser 
545                 550                 555                 560 


Arg Ser Phe Ser Asp Arg Ile Lys Leu Met Lys Ser Asp Cys Lys Lys 
                565                 570                 575     


Arg Leu Lys Val Ile Lys Lys Tyr Ser Asp Asp Pro Ser Thr Arg Ile 
            580                 585                 590         


Pro Lys Val Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile Val Asp 
        595                 600                 605             


Met Ile Val Asp Lys Ser Leu Lys Met Arg Phe Thr Ser Phe Tyr Tyr 
    610                 615                 620                 


Asp Arg Met Gln Glu Ser Leu Ala Phe Tyr Ala Ala Ser Glu Lys Lys 
625                 630                 635                 640 


Asp Leu Phe Arg Ala Ile Val Asp Glu Leu Arg Ile Phe Glu Lys Asp 
                645                 650                 655     


Gly His Pro Phe Leu Glu Asn Val Leu Lys Lys Ser Pro Ser Asn Thr 
            660                 665                 670         


Leu Asp Phe Tyr Thr Cys Tyr Leu Lys Glu Lys Ala Asp Thr Arg Asn 
        675                 680                 685             


Asn Asn Phe Glu Lys Asn Asn Ser Trp Ile Asp Arg Val Phe Phe Thr 
    690                 695                 700                 


Thr Val Phe Asn Asp Lys Ile Asn Lys Lys Met Val Thr Val Arg Met 
705                 710                 715                 720 


Pro Glu Asp Thr Ser Asn Ile Pro Tyr Thr Ile Arg Ile Trp Ala Glu 
                725                 730                 735     


Lys Asp Lys Val Asp Leu Trp Lys Trp Leu Asn Asn Ile Thr Thr Leu 
            740                 745                 750         


Asn Lys Lys Pro Ile Asp Leu Pro Val Asn Leu Phe Asp Ser Lys Leu 
        755                 760                 765             


His Glu Leu Leu Cys Leu Glu Leu Asp Lys Lys Ala Val Thr Tyr Asn 
    770                 775                 780                 


Pro Glu Ser Lys Trp Asn Glu Leu Leu Lys Leu Trp Trp Asn Thr Arg 
785                 790                 795                 800 


Asn Asp Gly Val Gln Trp Phe Tyr Ser Ala Glu Arg Glu Tyr Ser Ile 
                805                 810                 815     


Tyr Asn Glu Lys Ile His Phe Ile Pro Asp Ser Lys Glu Thr Phe Lys 
            820                 825                 830         


Glu Tyr Tyr Val Ser Ala Phe Thr Lys Val Asn Gln Asn Asn Lys Arg 
        835                 840                 845             


Gly Arg Lys Lys Pro Ile Asn Lys Gln Leu Glu His Val Phe Lys Arg 
    850                 855                 860                 


Ser Ile Ala Glu Ser Glu Lys Lys Phe Arg Ile Leu Gln Glu Glu Asp 
865                 870                 875                 880 


Arg Leu Ile Val Leu Met Val Glu Lys Leu Met Lys Glu Lys Asn Val 
                885                 890                 895     


Asn Ile Glu Asn Leu Gln Leu Ser Asn Val Ala Lys Leu Ile Ser Glu 
            900                 905                 910         


Glu Ile His Val Glu Met Val Leu Glu Tyr Asp Asn Asn Gly Asn Ile 
        915                 920                 925             


Ile Tyr Lys Asn Ile Thr Gln Pro Ser Lys Lys Asn Met Ile Val Thr 
    930                 935                 940                 


Arg Cys Lys Arg Lys Asn Tyr Thr Leu Leu His Lys Tyr Arg Tyr Asp 
945                 950                 955                 960 


Arg Arg Leu Pro Gly Leu Phe Glu Tyr Cys Gln Thr Gln Glu Val Gln 
                965                 970                 975     


His Asp Trp Leu Lys Lys Glu Leu Asp Ser Tyr Asn Arg Ala Lys Gln 
            980                 985                 990         


Val Val Phe Asp Ser Ala Phe Lys  Leu Glu Lys His Ile  Ile Ala Tyr 
        995                 1000                 1005             


Asp Lys  Asp Gly Leu Val Lys  Leu Tyr Val Asp Glu  Asn Asn Asn 
    1010                 1015                 1020             


Ser Leu  Thr Gly Asn Val Val  His Lys Pro Tyr Leu  Asn Trp Met 
    1025                 1030                 1035             


Val Ser  Lys Asn Leu Ile Thr  Asn Glu Glu Cys Asp  Phe Leu His 
    1040                 1045                 1050             


Thr Val  Arg Asn Lys Phe Ala  His Asn Gln Phe Pro  Arg Lys Glu 
    1055                 1060                 1065             


Ile Val  Lys Asp Met Phe Asp  Leu Asp Tyr Ser Ser  Pro Ile Ala 
    1070                 1075                 1080             


Glu Gln  Ile Ser Glu Val Tyr  Arg Gln Lys Ile Asn  Asp Val Ile 
    1085                 1090                 1095             


Ser Lys  Lys Ala Ile His 
    1100                 


<210>  1951
<211>  1211
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1951

Leu Ile Leu Ser Phe Ile Ile Phe Asn Phe Arg Val Ile Ile Asn Gln 
1               5                   10                  15      


His Thr Leu Asn Thr Tyr Thr Arg Lys Tyr Met Lys Asp Lys Ser Phe 
            20                  25                  30          


Ser Thr Thr Ser Ser Ala Ile Asn Glu Thr Ile Thr Thr Asp Asn Leu 
        35                  40                  45              


Lys Tyr Pro Glu Arg Leu Asn Leu Ile Leu Ser Lys Arg Leu Arg Pro 
    50                  55                  60                  


Lys Asn Glu Leu Gln Pro Leu Trp Ala Ala Tyr Phe Asn Met Ala Arg 
65                  70                  75                  80  


Tyr Asn Met Tyr Thr Thr Leu Val His Ile Ala Thr Ala Thr Gly Leu 
                85                  90                  95      


Ser Asp Glu Glu Asn Met Glu Asn Arg Met Asp Lys Met Arg Ile Leu 
            100                 105                 110         


Asn Glu Pro Val Glu Pro Glu Ile Glu His Ser Leu Arg Lys Leu Leu 
        115                 120                 125             


Cys Arg His Phe Pro Phe Ala Val Trp Ile Cys Ser Pro Ile Arg Lys 
    130                 135                 140                 


Lys Asp Ser Lys Glu Asp Ser Ala Asp Glu Asp Tyr Arg Val Ile Ser 
145                 150                 155                 160 


Val Lys Glu Leu Arg Asp Cys Leu Lys Thr Val Ser Tyr Thr Leu Asn 
                165                 170                 175     


Tyr Phe Arg Asn Tyr Tyr Ser His Thr Arg His Val Glu Thr Arg Ser 
            180                 185                 190         


Glu Asp Ile Ile Ala Ala Ser Arg Asn Ser Glu Lys Gln Thr Gly Ile 
        195                 200                 205             


Phe Leu Asn Lys Val Cys Thr Val Ala Thr Arg Arg Val Lys Ser Arg 
    210                 215                 220                 


Phe Gly Asp Lys Ser Asn Lys Gly Gln Ala Gly Met Ile Asp Asp Gln 
225                 230                 235                 240 


Ser Met Lys Phe Ile Thr Glu Gly Lys Val Lys Phe Arg Asn Asn Asn 
                245                 250                 255     


Gly Ile Lys Glu Thr Ile Tyr Asn Pro Asp His Phe Leu Tyr Pro Leu 
            260                 265                 270         


Phe Leu Asp Arg Ser Ser Ala Leu Arg Asp Gly Thr Asn Pro Glu Arg 
        275                 280                 285             


Leu Ser Thr Val Gly Lys Met Gln Leu Ile Cys Leu Leu Leu Asp Lys 
    290                 295                 300                 


Lys Tyr Ile Thr Glu Phe Leu Asp Gln Ala Gly Phe Leu Ser Ala Phe 
305                 310                 315                 320 


Asn Asn Asp Ala Leu Ala Pro Arg Leu Ser Glu Arg Arg Leu Ile Leu 
                325                 330                 335     


Glu Val Leu Ser Asp Leu Arg Ile Arg Leu Pro Arg Arg Lys Ile Asp 
            340                 345                 350         


Ala Thr Cys Asn Asp Ile Gln Val Ala Leu Asp Met Leu Asn Glu Leu 
        355                 360                 365             


Lys Lys Cys Pro Lys Glu Leu Phe Glu Leu Leu Glu Ala Lys Asp Lys 
    370                 375                 380                 


Ala Thr Phe Ser Ile Leu Ser Ser Thr Gly Glu His Ile Leu Leu Arg 
385                 390                 395                 400 


Arg Ser Ser Asp Arg Phe Thr Gln Leu Ala Leu Gln Trp Phe Asp Val 
                405                 410                 415     


Asn Lys Ala Phe Ser Arg Ile Arg Phe Gln Met Asn Ala Gly Ile Phe 
            420                 425                 430         


Arg Tyr Leu Phe Asn Asp Ser Lys Thr Cys Ile Asp Gly Lys Thr Arg 
        435                 440                 445             


Leu Arg Val Leu Gln Glu Pro Leu Asn Cys Phe Gly Arg Ile Gln Glu 
    450                 455                 460                 


Val Glu Asp Ser Arg Glu Ser Asn Arg Tyr Gly Asn Asp Gly Pro Trp 
465                 470                 475                 480 


Arg Gly Phe Glu Ile Lys Gly Phe Asp Glu Ala Ala Arg Asn Asp Val 
                485                 490                 495     


Asn Cys Leu Pro Tyr Ile Asn Asp Ser Arg Thr Arg Tyr Leu Ile Thr 
            500                 505                 510         


Glu Asp Asn Ile Gly Ile Arg Phe Ser Gly Asp Asp Glu Ala Cys Gly 
        515                 520                 525             


Asn Tyr Phe Pro Arg Ile Asp Glu Lys Asn Gly Lys Tyr Lys Val Thr 
    530                 535                 540                 


Cys Leu Pro Ala Gln Cys Met Ile Ser Ile Tyr Glu Leu Gln Ala Met 
545                 550                 555                 560 


Leu Phe Leu His Leu Leu Asn Pro Gly Asn Asp Gly Gly Ile Ala Pro 
                565                 570                 575     


Val Glu Lys Ile Ile Ile Asp Lys Val Glu Ser Tyr Arg Arg Phe Phe 
            580                 585                 590         


Ser Asp Ile Lys Asn Gly Leu Leu Thr Pro Ser Gly Leu Thr Glu Ser 
        595                 600                 605             


Ser Leu Asn Asp Lys Leu Thr Ser Thr Tyr Gly Ile Ser Leu Ser Asp 
    610                 615                 620                 


Ile Pro Asp Lys Met Lys Asp Tyr Leu Leu Lys Lys Asn Asn Lys Gly 
625                 630                 635                 640 


Arg Gly Phe Asn Ala Tyr Arg Asp Arg Leu Ile Glu Thr Leu Lys Glu 
                645                 650                 655     


Glu Thr Glu Tyr Arg Ile Lys Arg Leu Glu Glu Asn Leu Asn Ala Thr 
            660                 665                 670         


Asn Ser Asp Ile Asn Lys Pro Gly Lys Pro Gly Tyr Val Gln Ile Lys 
        675                 680                 685             


Pro Gly Ser Leu Ala Ser Phe Ile Ser Lys Asp Ile Val Phe Phe Gln 
    690                 695                 700                 


Glu Cys Asn Ala Asp Gln Lys Met Thr Gly Leu Asn Phe Ser Val Met 
705                 710                 715                 720 


Gln Gly Leu Ile Ala Thr Phe Gly Ser Gln Glu Gly Ala Thr Thr Asp 
                725                 730                 735     


Asp Leu Arg Met Ala Phe Arg Lys Ser Gly Leu Ile Ala Ala Asn Gly 
            740                 745                 750         


Ser Cys Gly Thr His Pro Phe Leu Ala Ile Ala Phe Asn Ala Gly Val 
        755                 760                 765             


Lys Asn Thr Leu Asp Leu Tyr Glu Lys Tyr Leu Asn Ala Arg Lys Ser 
    770                 775                 780                 


Tyr Leu Ser Gly Ile Ile Pro Asp Asn Ala Pro Phe Leu His Ala Asp 
785                 790                 795                 800 


Arg Ile Arg Trp Thr Ile Asn Asp Asp Ala Tyr Tyr Lys Asp Tyr Ala 
                805                 810                 815     


Glu Arg Cys Leu Gln Arg Pro Val Ile Leu Pro Arg Arg Leu Phe Glu 
            820                 825                 830         


Ala Ser Ile Arg Glu Asn Leu Leu Ala Leu Asn Gly Glu Asn Ala Asn 
        835                 840                 845             


Ala Leu Lys Lys Val Ile Ile Gly Ala Gly Gly His Cys Asn Ser Ala 
    850                 855                 860                 


Phe Met Ile Asp Ser Tyr Phe Tyr Tyr Val Lys Asn Asp Ser Pro Gln 
865                 870                 875                 880 


Val Phe His Gly Ala Cys Glu Gly Asp Met Leu His Thr Tyr Gly His 
                885                 890                 895     


Arg Phe Phe Gln Val Val Arg Arg Asn Leu Lys Asn Ala Glu Ala Ile 
            900                 905                 910         


Leu Ser Lys Leu Lys Lys Asp Ser Asn Thr His Asn Thr Tyr Ile Gly 
        915                 920                 925             


Ala Leu Ser Asp Ala Ile Cys Trp Ala Lys Glu Asn Pro Ile Lys Pro 
    930                 935                 940                 


Thr Phe Ser Val Gly Arg Ser Arg Leu Asn Asn His Ser Glu Asn Glu 
945                 950                 955                 960 


Ile Val Ala Met Ile Lys Arg Ala Phe Asn Glu Tyr Met Ala Thr Glu 
                965                 970                 975     


Lys Thr Leu Arg Arg Tyr Val Ile Gln Asp Glu Leu Leu Phe Leu Ala 
            980                 985                 990         


Ala Met Lys Thr Ile Lys Ser Lys  Leu Gly Val Pro Asp  Gly Glu Trp 
        995                 1000                 1005             


Lys Leu  Gly Ser Ile Gly Ser  Lys Ser Gly Ser Ile  Leu Asp Lys 
    1010                 1015                 1020             


Glu Leu  Pro Leu Ile Gln Thr  Pro Ala Lys Phe Ser  Asn Ile Lys 
    1025                 1030                 1035             


Lys Arg  Pro Tyr Thr Lys Lys  Asp Leu Val Glu Phe  Val Ile Glu 
    1040                 1045                 1050             


Gln His  Asn Val Ser Ile Lys  Asp Tyr Gly Glu Ile  Tyr Arg Ile 
    1055                 1060                 1065             


Leu Ala  Asp Glu Arg Leu Tyr  Gly Leu Leu Lys Tyr  His Lys Asn 
    1070                 1075                 1080             


Glu Ile  Val Leu Ala Ser Asp  Leu Lys Asn Glu Ile  Glu Lys Tyr 
    1085                 1090                 1095             


Asp Glu  Lys Arg Val Lys Val  Phe Glu Asp Ile Met  Asn Tyr Glu 
    1100                 1105                 1110             


Lys Lys  Ile Thr Asn Gly Val  Thr Asp Arg Gln Leu  Cys Glu Ser 
    1115                 1120                 1125             


Met Asp  Lys Glu His Pro Lys  Asp Ile Asp Phe Lys  Val Met Gln 
    1130                 1135                 1140             


Thr Phe  Asp Thr Met Asn Asp  Asn Leu Thr Lys Met  Glu Leu Arg 
    1145                 1150                 1155             


Ser Ile  Arg Asn Ala Phe Cys  His Asn Ser Tyr Pro  Asp Val Asn 
    1160                 1165                 1170             


Ala Phe  Asp Asp Ser Ser Arg  Thr Thr Lys Arg Ile  His Asn Ala 
    1175                 1180                 1185             


Asp Ile  Pro Gly Thr Ala Glu  Lys Ile Ser Gly Ile  Val Asn Asp 
    1190                 1195                 1200             


Ile Ser  Ser Lys Thr Glu Ala  Lys 
    1205                 1210     


<210>  1952
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1952

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Met Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Met Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Val Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1953
<211>  985
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1953

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Asn Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys Gly Tyr 
                165                 170                 175     


Ala Phe Phe Ile Ser Lys Phe Leu Glu Arg Lys Tyr Ser Tyr Leu Phe 
            180                 185                 190         


Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln Tyr Arg 
        195                 200                 205             


Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro Val Glu 
    210                 215                 220                 


Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu Asp Ile 
225                 230                 235                 240 


Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr Leu Glu 
                245                 250                 255     


Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr Asp Ala 
            260                 265                 270         


Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe Arg Ser 
        275                 280                 285             


Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala Asp Phe 
    290                 295                 300                 


Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His Asn Gly 
305                 310                 315                 320 


Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr Ile Asn 
                325                 330                 335     


Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser Ala Lys 
            340                 345                 350         


Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser Thr Asp 
        355                 360                 365             


Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln Ser Thr 
    370                 375                 380                 


Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val Leu Pro 
385                 390                 395                 400 


Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala Lys Met 
                405                 410                 415     


Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala Met Leu 
            420                 425                 430         


Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His Cys Pro 
        435                 440                 445             


Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser Thr Lys 
    450                 455                 460                 


Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg Val Met 
465                 470                 475                 480 


Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu Arg Ile 
                485                 490                 495     


Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile Leu Lys 
            500                 505                 510         


Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp Leu Gln 
        515                 520                 525             


Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn Phe Gln 
    530                 535                 540                 


Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn Asp Leu 
545                 550                 555                 560 


Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn Pro His 
                565                 570                 575     


Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile Glu Phe 
            580                 585                 590         


Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg Ile Gln 
        595                 600                 605             


Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro Leu Arg 
    610                 615                 620                 


Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu Ala Ile 
625                 630                 635                 640 


Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys Leu Lys 
                645                 650                 655     


Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu Lys Ser 
            660                 665                 670         


Pro Ala Leu Asn Val Ser Tyr Leu Ile His Asn Tyr Phe Arg Ala Tyr 
        675                 680                 685             


Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn Tyr Arg 
    690                 695                 700                 


Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser Tyr Leu 
705                 710                 715                 720 


Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro Ser Lys 
                725                 730                 735     


Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp Arg Leu 
            740                 745                 750         


Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile Ile Arg 
        755                 760                 765             


Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys Glu Tyr 
    770                 775                 780                 


Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu Glu Asn 
785                 790                 795                 800 


Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp Leu Asn 
                805                 810                 815     


Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr Gly Lys 
            820                 825                 830         


Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn Lys Val 
        835                 840                 845             


Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val Lys Ile 
    850                 855                 860                 


Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu Glu Ala 
865                 870                 875                 880 


Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala Met Val 
                885                 890                 895     


Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr Tyr Asp 
            900                 905                 910         


Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln Lys Ile 
        915                 920                 925             


Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His Asp Lys 
    930                 935                 940                 


Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val Tyr Ala 
945                 950                 955                 960 


Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile Lys Leu 
                965                 970                 975     


Glu Asp Leu Ser Asn Asp Ser Ser Ala 
            980                 985 


<210>  1954
<211>  1025
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1954

Met Glu Thr Lys Glu Gln Ile Gly Lys Asn Val Tyr Lys Thr Ser Glu 
1               5                   10                  15      


Asn Asp Pro Leu Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg His Asn 
            20                  25                  30          


Val Phe Leu Ile Ile Asn His Leu Thr Glu Val Phe Asp Ser Leu Gly 
        35                  40                  45              


Tyr Thr Lys Ile Asn Asp Asp Glu Asp Ile Val Asn Gln Asp His Ile 
    50                  55                  60                  


Leu Ser Gln Ile Phe Asp Pro Ser Lys Lys Glu Leu Glu Asn Glu Arg 
65                  70                  75                  80  


Ile Arg Ile Tyr Asn Tyr Met Ile Lys Arg His His Leu Pro Phe Leu 
                85                  90                  95      


Lys Val Phe Asn Ser Glu Ile Leu Asn Asp Glu Asp Gly Glu Asn Met 
            100                 105                 110         


Gly Ile Asp Phe Lys Ser Leu His Asn Phe Ile Ile Lys Ser Phe Lys 
        115                 120                 125             


Thr Leu Asn Asp Leu Arg Asn Ser Tyr Ser His Tyr Leu Ala Ile Asp 
    130                 135                 140                 


Asp Asp Gly Asn Lys Ile Glu Lys Arg Ser Asn Ile Val Asp Val Ser 
145                 150                 155                 160 


Ile Lys Ser Asp Ile Lys Gln Leu Phe Lys His Ala Pro Lys Phe Ser 
                165                 170                 175     


Phe Ile Arg Asn Gln Glu Thr Gln His Glu Glu Asp Tyr Asn His Leu 
            180                 185                 190         


Asp Arg Tyr Arg Ile Phe Glu Asn Glu Thr Asn Ile Leu Thr Asp Gln 
        195                 200                 205             


Gly Leu Tyr Phe Phe Ile Asn Leu Phe Leu Glu Arg Asn His Ala Thr 
    210                 215                 220                 


Lys Phe Leu Lys Lys Ile Lys Gly Phe Lys Asn Glu Thr Thr Pro Pro 
225                 230                 235                 240 


Phe Arg Ala Thr Ile Gln Ser Phe Thr Ser Phe Ala Leu Lys Leu Pro 
                245                 250                 255     


Asp Ile Arg Leu Ser Asn Glu Arg Pro Leu Phe Ser Leu Leu Met Asn 
            260                 265                 270         


Met Leu Thr Glu Leu Asn Lys Cys Pro Lys Glu Leu Phe Asn His Leu 
        275                 280                 285             


Thr Gln Lys Asp Lys Lys Glu Phe Glu Pro Leu Leu Asn Asp Glu Glu 
    290                 295                 300                 


Lys His Asn Val Val Leu Asn Ser Thr Asn Tyr Ser Glu Ile Ser Asp 
305                 310                 315                 320 


Asp Glu Leu Asp Glu Ala Ile Arg Glu Ile Thr Ala Leu Lys Arg Tyr 
                325                 330                 335     


Asn Asp Arg Phe Pro Tyr Phe Ala Leu Arg Phe Leu Asp Glu Thr Asn 
            340                 345                 350         


Ala Leu Lys Asn Ile Arg Phe Gln Ile Thr Leu Gly Lys Leu Ile Ile 
        355                 360                 365             


Lys Arg Tyr Asp Lys Glu Ile Ala Gly Ile Glu Glu Asn Arg Arg Val 
    370                 375                 380                 


Ile Lys Thr Ile Asn Ala Phe Gly Lys Leu Ser Asp Phe Ile Asp Asn 
385                 390                 395                 400 


Glu Glu Val Val Leu Lys Glu Leu Lys Lys Asn Leu Ala Asp Asn Asn 
                405                 410                 415     


Asp Ile Arg Phe Glu Gln Tyr Ser Pro His Tyr Asn Thr Asn Asn Ile 
            420                 425                 430         


Lys Ile Ala Phe Tyr Val Phe Asp Glu Gly Asp Asp Lys Thr Lys Tyr 
        435                 440                 445             


Pro Phe Val Phe Glu Asn Lys Glu Asn Asn Ser Asp Ile Gln Asn Asn 
    450                 455                 460                 


Pro Ser Gly Phe Leu Ser Ile His Asp Leu Pro Lys Met Leu Leu Phe 
465                 470                 475                 480 


Glu Cys Leu Asp Ile Asn Leu Lys Pro Glu Asn Ile Ile Ile Asp Phe 
                485                 490                 495     


Ile Arg Ser Thr Asn Leu Glu Met Phe Asp Leu Ser Glu Leu Glu Lys 
            500                 505                 510         


Ile Arg Lys Gln Ala Asn Tyr Glu Pro Glu Tyr Phe Ser Lys Arg Ile 
        515                 520                 525             


Asn Lys Glu Lys Tyr Leu Ile Ser Lys Lys Gly Ile Lys Tyr Leu Ser 
    530                 535                 540                 


Lys Glu Val Glu Asn Asn Met Leu Glu Asp Leu Gly Leu Ser Lys Asp 
545                 550                 555                 560 


Glu Leu Ile Leu Lys Asp Lys Asp Ser Phe Met Lys Leu Thr Asn Ser 
                565                 570                 575     


Lys Lys Tyr Ile Glu Tyr Phe Ser Gln Ile Lys Tyr Gln Tyr Tyr Leu 
            580                 585                 590         


Gln Lys Arg Arg Glu Glu Leu Gln Arg His Leu Pro Lys Gly Leu Lys 
        595                 600                 605             


Ile Asp Leu Leu Pro Glu Asn Ile Leu Glu Tyr Leu Met Asp Phe Lys 
    610                 615                 620                 


Glu Arg Asn Asn Glu Gly Ile Ile His Gln Lys Val Ala Ala Ile Arg 
625                 630                 635                 640 


Asp Glu Ala Lys Asn Leu Lys Lys Ser Ile Glu Ser Glu Val Glu Lys 
                645                 650                 655     


Pro Lys Asn Glu Gln Arg Ile Lys Leu Gly Glu Leu Ala Thr Phe Val 
            660                 665                 670         


Ala Arg Asp Ile Ile Lys Met Val Ile Cys Lys Glu Val Lys Asp Lys 
        675                 680                 685             


Ile Thr Ser Pro Tyr Tyr Asn Lys Leu Gln Asn Lys Ile Ala Tyr Phe 
    690                 695                 700                 


Ser Leu Asn Lys Asp Glu Leu Ile Asp Ile Cys Asp Glu Leu Lys Leu 
705                 710                 715                 720 


Phe Asn Glu Asn Glu Gly His Val Phe Phe Lys Lys Glu Leu Ile Lys 
                725                 730                 735     


Asn Ser Asp Gly Ile Ile Asp Phe Thr Leu Asp Tyr Leu Arg Ala Lys 
            740                 745                 750         


Asp Asn Trp Ile Glu Thr Lys Leu Leu Lys Lys Gly Lys Thr Gly Gly 
        755                 760                 765             


Tyr Arg Phe Pro Asp Lys Thr Lys Ile Pro Leu Ser Phe Asn Lys Ile 
    770                 775                 780                 


Lys Asn Lys Ala Asn Ser Phe Asp Phe Lys Thr Trp Leu Lys Asn Lys 
785                 790                 795                 800 


Ser Gln Leu Pro Val Asp Leu Pro Arg Ser Leu Phe Asp Glu Lys Leu 
                805                 810                 815     


Glu Ile Ile Leu Lys Gly Lys Leu Asn Gln Lys Gly Ile Ile Phe Asn 
            820                 825                 830         


Thr Gly Asp Lys Phe Ser Val Leu Leu Ser Lys Tyr Leu Asn Asn Asp 
        835                 840                 845             


Thr Gln Val Phe Tyr Asn Tyr Cys Arg Ser Tyr Ser Ile Asn Lys Lys 
    850                 855                 860                 


Ile Glu Glu Phe Glu Ile Ser Gly Leu Ser Gly Lys Glu Ile Lys Lys 
865                 870                 875                 880 


Asn Phe Asp Ser Asn Val Glu Lys Asn Glu Lys Ser Ile Arg Phe Ile 
                885                 890                 895     


Gln Thr Lys Asp Arg Val Leu Lys Leu Ile Ser Asp Lys Ile Leu Ser 
            900                 905                 910         


Ile Asp Arg Ser Ile Gly Leu Gln Ser Gly Phe Cys Leu Thr Asp Ile 
        915                 920                 925             


His Pro Ala Ala Lys His Asn Pro Leu Asp Cys Pro Ala Val Phe Glu 
    930                 935                 940                 


Gln Lys Ile Ile Arg Arg Gly Asp Glu Val Phe Cys Asn Ile Ile Ala 
945                 950                 955                 960 


Lys Asp Thr Glu Asn Gln Ile Gln Ser Val Lys His Phe Glu Ser Leu 
                965                 970                 975     


Gln Ala Glu Glu Glu Lys Glu Ala Tyr Pro Asp Gln Lys Trp Tyr Gln 
            980                 985                 990         


Trp Thr Ile Lys Asp Phe Gly Arg  Phe Lys Arg Phe Ile  Lys Asp Arg 
        995                 1000                 1005             


Arg Ile  Pro Asn Leu Ser Asn  Tyr Phe Glu Asp Lys  Asn Ile Pro 
    1010                 1015                 1020             


Phe Asp  
    1025 


<210>  1955
<211>  1126
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1955

Met Glu Thr Asn Gln Lys Pro Asn Tyr Lys Lys Phe Thr Asn Glu Gln 
1               5                   10                  15      


Asp Lys Pro Phe Phe Ser Gly Tyr Leu Asn Thr Ala Lys Gln Asn Val 
            20                  25                  30          


Phe Ile Ile Phe Arg Asp Ile Ser Glu Arg Leu Gly Leu Gly Phe Asp 
        35                  40                  45              


Leu Ser Asn Asp Asp Asn Ile Met Asn Ala Asp Leu Trp Glu Tyr Leu 
    50                  55                  60                  


Lys Asn Asn Lys Arg Pro Glu Ile Thr Gln His Ile Ile Glu Lys Leu 
65                  70                  75                  80  


Met Tyr His Phe Pro Phe Ala Ser His Leu Thr Thr Asn Tyr Ala Tyr 
                85                  90                  95      


Tyr Lys Arg Lys Glu Asn Gln Ala Glu Pro Leu Asp Tyr Tyr Glu Ile 
            100                 105                 110         


Phe Glu Leu Leu Ile Lys Gln Leu Tyr Glu Tyr Arg Asn Phe Tyr Thr 
        115                 120                 125             


His Val Val His Asp Pro Val Ile Met Asn Lys Val Ile Ile Asn Gly 
    130                 135                 140                 


Met Arg Ile Leu Phe Asp Ala Ala Arg Ile Glu Val Lys Asp Arg Phe 
145                 150                 155                 160 


Asn Leu Lys Thr Glu Asp Val Asn His Leu Val Arg Leu Gly Pro Lys 
                165                 170                 175     


Gly Lys Glu Asn Lys Asn Phe Tyr Tyr Asn Phe Ser Asp Asp Glu Arg 
            180                 185                 190         


Asn Val Ser Glu Lys Gly Leu Ala Phe Phe Ile Cys Leu Gly Leu Gln 
        195                 200                 205             


Arg Lys Asp Ala Gln Ile Phe Leu Lys Ser Leu Val Gly Phe Lys Leu 
    210                 215                 220                 


Ser Glu Ser Pro Ser Gln Lys Ala Thr Leu Glu Val Tyr Thr Asn Tyr 
225                 230                 235                 240 


Ser Pro Arg Ile Pro Gln Pro Arg Leu Thr Ser Asp Asn Ser Ile Glu 
                245                 250                 255     


Gly Leu Leu Leu Asp Met Val Asn Glu Leu Lys Arg Cys Pro Lys Glu 
            260                 265                 270         


Leu Tyr His Leu Leu Ser Ile Glu Asp Arg Glu Lys Phe Lys Ala Val 
        275                 280                 285             


Lys Glu Asp Asn Thr Tyr Asp Asp Asn Asp Glu Tyr Glu Ala Met Pro 
    290                 295                 300                 


Val Leu Lys Arg Ser Arg Asn Arg Phe Phe Tyr Phe Ala Leu Arg Tyr 
305                 310                 315                 320 


Leu Asp Asn Asn Leu Gln Asn Ile Lys Phe His Ile Asp Leu Gly Asn 
                325                 330                 335     


Tyr Cys Phe His Val Tyr Glu Gln Glu Ile Glu Glu Ile Val Arg Lys 
            340                 345                 350         


Arg Arg Trp Ile Lys Arg Met Thr Ser Phe Gly Asn Leu Glu Asp Phe 
        355                 360                 365             


Ala Asp Lys Met Arg Pro Ala Tyr Trp Val Glu Lys Thr Leu Lys Leu 
    370                 375                 380                 


Glu Asp Lys Lys Val Asp Asn Pro Asn Ile Tyr Ile Thr Asp Thr Thr 
385                 390                 395                 400 


Pro His Tyr His Ile Asn Gly Gln Asn Ile Gly Ile Lys Phe Ile Asn 
                405                 410                 415     


Asn Tyr Val Ala Leu Arg Lys Asn Asn Lys Ile Trp Pro Glu Leu Pro 
            420                 425                 430         


Asp Phe Gly Asp Asn Asn Lys Thr Asn Lys Pro Arg Asn Glu Thr Pro 
        435                 440                 445             


Asp Cys Trp Leu Ser Leu Tyr Glu Leu Pro Ser Ile Val Phe Tyr His 
    450                 455                 460                 


Leu Leu Lys Gln Gln Asn Ile Gly Leu Pro Ser Val Glu Arg Ile Ile 
465                 470                 475                 480 


Asn Asp His Arg Asn Gln Ile Arg Gly Phe Phe Asn Asp Leu Glu Asn 
                485                 490                 495     


Asn Arg Ile Val Pro Ser Phe Thr Asp Thr Thr Leu Lys Ala Glu Leu 
            500                 505                 510         


Lys Asn Arg Gly Leu Lys Lys Ser Gln Ile Pro Ser Ala Ile Val Lys 
        515                 520                 525             


Tyr Leu Thr Ser Lys Pro Val Met Ser Phe Glu Ala Lys Ala Ser Lys 
    530                 535                 540                 


Arg Leu Ser Glu Leu Val Thr Glu Thr Ser Glu Lys Leu Asp Lys Ile 
545                 550                 555                 560 


Lys Arg Gln Glu Gln His Tyr Leu Lys Lys Pro Gly Ser Lys Asp Tyr 
                565                 570                 575     


Ile Asp Met Lys Cys Gly His Leu Ala Asp Phe Leu Ala Arg Asp Met 
            580                 585                 590         


Ile Ser Leu Gln Lys Pro Tyr Asn Asn Met Asp Gly Lys Ala Asn Ser 
        595                 600                 605             


Thr Glu Phe Gln Ile Leu Gln Ser Lys Leu Ala Tyr Phe Gly Lys Asn 
    610                 615                 620                 


Lys Asp Ser Leu Ser Lys Thr Phe His Leu Phe Asn Leu Met Gly Ser 
625                 630                 635                 640 


Gln Asn Ile His Pro Phe Leu Tyr Lys Ile Asp Ile Asn Gln Cys Ile 
                645                 650                 655     


Gly Ile Leu Asp Phe Tyr Lys Lys Tyr Leu Asp His Arg Tyr Ile Tyr 
            660                 665                 670         


Phe Lys Gln Cys Leu Asn Glu Lys Arg Tyr Ser Glu Tyr His Phe Leu 
        675                 680                 685             


Lys Leu Gly Gly Lys Ser Lys Glu Gln Gly Arg Asp Tyr Phe Val Lys 
    690                 695                 700                 


Leu Ala Asn Thr Leu Gln Lys Glu Thr Val Met Asn Leu Pro Arg Gly 
705                 710                 715                 720 


Leu Phe Leu Glu Ser Ile Ile Arg Ile Leu Lys Ala Asn Asp Asn Ser 
                725                 730                 735     


Arg Pro Phe Ala Ile Glu Ile Glu Lys Met Glu Arg Val Asn Ala Ala 
            740                 745                 750         


Tyr Val Ile Asp Gln Tyr Leu Gly Arg Ile Leu Asn Asp Lys Pro Gln 
        755                 760                 765             


Val Phe Tyr Ser Tyr Asn Lys Ser Tyr Glu Phe Leu Asn Lys Leu Phe 
    770                 775                 780                 


Asp Ser Arg Lys Ile Ser Glu Lys Arg Asn Ala Leu Pro Glu Val Tyr 
785                 790                 795                 800 


Phe Asp Thr Gly Glu Leu Ala Lys Lys Thr Thr Ile Ser Val Lys Gly 
                805                 810                 815     


Gln Lys Asp Asn Glu Ile Thr Arg Ser Leu Thr Lys Thr Val Glu Gln 
            820                 825                 830         


His Ile Lys Arg Asn Arg Ile Phe Asp Glu Lys Glu Lys Thr Lys Val 
        835                 840                 845             


Tyr Asp Gln Tyr Met Ala Arg Tyr Asn Asp Phe Thr Glu Asn Glu Lys 
    850                 855                 860                 


Gln Ile Arg Leu Ala Lys Thr Cys Asp Glu Val Met Phe Met Met Ile 
865                 870                 875                 880 


Asp Asp Ile Phe Arg Lys Tyr Phe Val Leu Asp Asn Gly Thr Leu Lys 
                885                 890                 895     


Lys Lys Thr Ile Glu Ala Ile Pro Phe Ile Gln Leu Gly Asp Asp Tyr 
            900                 905                 910         


Lys Leu Gly Ser Ile Lys Pro Asp Ser Glu Lys Gly Phe Leu Ser Leu 
        915                 920                 925             


Gln Thr Thr Val Lys Leu Gln Met Pro Phe Thr Tyr Glu Thr Asn Thr 
    930                 935                 940                 


Asp Lys Val Leu Lys Val Lys Gly Ala Glu Ser Lys Leu Ser Ala Arg 
945                 950                 955                 960 


Tyr Ile Lys Thr Ile Val Arg Glu Thr Ile Lys Ile Lys Asn Tyr Gly 
                965                 970                 975     


Asp Phe Arg Ala Phe Leu Lys Asp Arg Arg Ile Ser Ser Leu Leu Pro 
            980                 985                 990         


Tyr Leu Ser Asp Arg Glu Ile His  Tyr Glu Ala Leu Gln  Lys Glu Leu 
        995                 1000                 1005             


Glu Leu  Phe Gln Lys Ala Arg  Met Glu Val Phe Asp  Arg Ile Phe 
    1010                 1015                 1020             


Arg Phe  Glu Lys Asp Ile Thr  Gly Ala Phe His Ile  Pro Lys Asn 
    1025                 1030                 1035             


Lys Asn  Gly Tyr Ile Tyr His  Thr Glu Ile Leu Lys  Gln Lys Ile 
    1040                 1045                 1050             


Asn Glu  Gly Asp Glu Arg Phe  Gly Phe Ile Lys Glu  Leu Arg Asn 
    1055                 1060                 1065             


Ala Phe  Asn His Ser Asn Tyr  Pro Ala Tyr Val Leu  Phe Lys Asp 
    1070                 1075                 1080             


Phe Ile  Asp Gly Ser Gln Phe  Asn Glu Leu Arg Asn  Tyr Lys Ser 
    1085                 1090                 1095             


Gly Asp  Thr Glu Val Glu Asn  Lys Ser Val Ile Leu  Gln Phe Lys 
    1100                 1105                 1110             


Asn Leu  Leu Ile Gln Tyr Tyr  Asp Glu Leu Thr Asp  Leu 
    1115                 1120                 1125     


<210>  1956
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1956

Met Glu Lys Glu Lys Leu Gly Met Gly Ile Gln Tyr Asp His Ser Ile 
1               5                   10                  15      


Lys Ala Asp Lys His Phe Phe Gly Gly Phe Leu Asn Leu Ala Glu Asn 
            20                  25                  30          


Asn Ile Ala Thr Val Phe Asn Ser Phe Asn Asn Arg Tyr Arg Lys Val 
        35                  40                  45              


Ser Asn Asp Glu Lys Lys Ile Asn Asn Thr Ala Leu Ile Asp Glu Cys 
    50                  55                  60                  


Phe Ser Asp Thr Val Ser Asp Ala Glu Tyr Lys Thr Arg Ile Asp Phe 
65                  70                  75                  80  


Leu Lys Met Tyr Phe Pro Ile Ile Asn Tyr Ile Glu Lys Glu Asn Asn 
                85                  90                  95      


Asn Arg Asn His Phe Arg Leu Arg Phe Val Gln Leu Ile Lys Thr Ile 
            100                 105                 110         


Asn Asp Leu Arg Asn Phe Tyr Thr His Tyr Tyr His Lys Gln Leu Glu 
        115                 120                 125             


Ile Asp Glu Asn Phe Phe Asn Phe Leu Asp Asp Thr Phe Leu Thr Ile 
    130                 135                 140                 


Val Gln Asp Val Lys Lys His Lys Met Lys Asp Asp Lys Thr Arg His 
145                 150                 155                 160 


Leu Leu Ser Lys Asn Leu Ser Glu Asn Leu Asp Gln Leu Tyr Lys Ser 
                165                 170                 175     


Lys Lys Gln Gln Leu Glu Gln Met Lys Lys Glu Gly Lys Lys Val Asn 
            180                 185                 190         


Leu Asp Asp Ile Ser Ile Lys Asn Ser Val Leu Asn Asp Ser Phe Phe 
        195                 200                 205             


His Leu Leu Tyr Lys Lys Asp Gln Val Asn Gln Val Tyr Lys Ser Lys 
    210                 215                 220                 


Leu Asn Gly Thr Ala Glu Asn Asn Ile Ile Leu Ser Gln Ser Gly Leu 
225                 230                 235                 240 


Ile Phe Leu Leu Gly Met Phe Leu Thr Lys Lys Glu Ser Glu Asp Leu 
                245                 250                 255     


Arg Ser Arg Val Arg Gly Phe Lys Ala Lys Phe Val Lys Ser Asp Asp 
            260                 265                 270         


Leu Ser Asn Asn Ile Lys Phe Met Ala Thr His Trp Val Phe Ser Tyr 
        275                 280                 285             


Leu Ala Tyr Lys Gly His Lys His Arg Leu Ala Gly His Phe Gln Gln 
    290                 295                 300                 


Glu Gly Leu Leu Ile Gln Ile Ile Asp Glu Leu Ser Lys Val Pro Asp 
305                 310                 315                 320 


Glu Val Tyr Val Thr Leu Asp Lys Glu Lys Gln Asn Ser Phe Ile Glu 
                325                 330                 335     


Asp Ile Asn Glu Tyr Leu Lys Ser Gly Lys Glu Asp Leu Ser Leu Glu 
            340                 345                 350         


Asp Ser Ile Val Val His Pro Val Ile Arg Lys Arg Tyr Glu Asn Lys 
        355                 360                 365             


Phe Asn Tyr Phe Ala Leu Arg Tyr Leu Asp Gln Phe Ala Asp Phe Pro 
    370                 375                 380                 


Thr Leu Arg Phe Gln Ile His Leu Gly Asn Phe Val His Asp Arg Arg 
385                 390                 395                 400 


Leu Lys Asp Ile Gln Gly Thr Ala Phe Gln Thr Glu Arg Ile Val Lys 
                405                 410                 415     


Glu Lys Ile Asn Val Phe Ser Arg Leu Ser Glu Val Ser Asn Leu Lys 
            420                 425                 430         


Ser Ser Tyr Ile Gln Asn Asn Lys Asn Glu Asp Asp Ile Asn Gly Trp 
        435                 440                 445             


Glu Ile Phe Pro Asn Pro Ser Tyr Asn Phe Ala Ala Asn Asn Ile Pro 
    450                 455                 460                 


Ile Phe Ile Asn Leu Gln Asn Ser Lys Leu Glu Gly Ala Lys Lys Leu 
465                 470                 475                 480 


Tyr Gly Gln Leu Lys Gln Ile Lys Asn Gln Pro Glu Glu Asn Asp Lys 
                485                 490                 495     


Asn Lys Glu Lys Lys Asn Ile Thr Arg Asp Glu Ala Lys Leu Asn Lys 
            500                 505                 510         


Glu Gln Ile Thr Gln Leu Val Asp Ser Asp Ile Gln Gly Gly Lys Phe 
        515                 520                 525             


Lys Asn Thr Tyr Ile Gly Pro Pro Leu Ala Met Leu Ser Leu Asn Glu 
    530                 535                 540                 


Leu Pro Ala Leu Leu Tyr Glu Leu Leu Val Lys Gly Val Pro Ala Lys 
545                 550                 555                 560 


Glu Ile Glu Asp Arg Met Val Ala Lys Leu Val Ala Arg Phe Lys Ile 
                565                 570                 575     


Ile Gln Asp Tyr Ser Pro Thr Gln Asn Ile Ser Ser Ser His Ile Thr 
            580                 585                 590         


Lys Lys Leu Arg Lys Ser Thr Asp Gln Val Gln Ile Asp Thr Ala Lys 
        595                 600                 605             


Ile Val Arg Ala Ala Asn Arg Glu Ile Glu Ile Thr Glu Gln Lys Leu 
    610                 615                 620                 


Ala Leu Ile Ser Gln Asn Arg Lys Asp Thr Lys Asn Ile Ser Gln Arg 
625                 630                 635                 640 


Arg Lys Tyr Val Phe Thr Thr Arg Glu Leu Gly Ile Glu Ala Ser Trp 
                645                 650                 655     


Leu Ala Tyr Asp Ile Lys Arg Phe Met Pro Lys Glu Asn Arg Glu Leu 
            660                 665                 670         


Leu Lys Gly Tyr Gln Phe Ala Gln Ile Gln His Ser Leu Ser Lys Phe 
        675                 680                 685             


Asp Ile Asn Asn Glu Glu Leu Ile Asn Thr Leu Ser Ala Val Trp Asn 
    690                 695                 700                 


Phe Lys Glu Asn Ser Ser Asp Phe Ser Gln Trp Val Arg Asp Ser Leu 
705                 710                 715                 720 


Leu Lys Ser Lys Ser Phe Asp Thr Ala Tyr Glu Val Trp Leu Lys Lys 
                725                 730                 735     


Arg Lys Glu Tyr Phe Gln Met Val Ala Glu Asn Leu Ser Ser Tyr Glu 
            740                 745                 750         


Leu Glu Ser Gly Leu Leu Lys Lys Phe Ile Lys Gln Gln Gln Ile Phe 
        755                 760                 765             


Glu Ile Phe Lys Glu Trp Leu Tyr Lys Ile Glu Ser Ser Gln Lys Gln 
    770                 775                 780                 


Ile His Arg Leu Leu Lys Thr Ala Leu Val Phe Pro Arg Gly Ile Phe 
785                 790                 795                 800 


Asp Asp Lys Pro Thr Phe Ile Gln Gly Ala Lys Ile Asn Glu Thr Pro 
                805                 810                 815     


Glu Leu Tyr Ala Asp Trp Tyr Gln Tyr Thr Tyr Gln Ser Ser His Gln 
            820                 825                 830         


Phe Gln Asn Phe Tyr Asp Leu Glu Arg Asp Tyr Thr Glu Trp Phe Asp 
        835                 840                 845             


Phe Glu Lys Leu Lys Asp Val Glu Ala Val Lys Asn Lys Lys Lys Leu 
    850                 855                 860                 


Asn Thr Asp Glu Gln Phe Ala Lys Leu Arg Leu Lys Gln Asp Ile Lys 
865                 870                 875                 880 


Ile Lys Gln Ile Lys Thr Gln Asp Leu Phe Leu Lys Leu Ile Ala Gln 
                885                 890                 895     


Asn Ile Tyr Asn Lys Ile Phe Asp Thr Asn Ile Ser Leu Glu Leu Lys 
            900                 905                 910         


Asp Leu Tyr Leu Thr Gln Glu Glu Arg Ile Lys Arg Glu Asn Lys Ala 
        915                 920                 925             


Leu Ile Gln Ser Asn Arg Lys Thr Gly Asp Ser Cys Gln Asn Ile Ile 
    930                 935                 940                 


Asn Asp Asn Phe Ile Trp Ser Met Thr Val Pro Phe Asp Gln Gly Gln 
945                 950                 955                 960 


Ile Ile Glu Pro Ala Val Lys Leu Lys Asp Leu Gly Lys Phe Lys Asn 
                965                 970                 975     


Phe Ile Ala Asp Pro Lys Val Gln Lys Leu Leu Gln Tyr Asp Thr Ala 
            980                 985                 990         


Lys Ile Trp Thr Lys Gln Met Leu  Asp Asp Glu Leu Phe  Ile Lys Ser 
        995                 1000                 1005             


Asn Ser  Tyr Glu Thr Ile Arg  Arg Glu His Ile Phe  Lys Ile Phe 
    1010                 1015                 1020             


Gln Asp  Phe Glu Lys Asp Ile  Leu Thr Leu Asn Asn  Phe Asp Gly 
    1025                 1030                 1035             


Ile Asn  His Pro Ser Asp Phe  Glu Gln Glu Asp Tyr  Lys Gly Asn 
    1040                 1045                 1050             


Arg His  Pro Asn Phe Lys Phe  Tyr Val Thr Lys Gly  Ile Leu Glu 
    1055                 1060                 1065             


Lys Phe  Asn Leu Ala Ala Ala  Gln Glu Ile Arg Trp  Leu Leu Glu 
    1070                 1075                 1080             


Leu Lys  Glu Asp Asn Ile Glu  His Thr Ser Ile Glu  Thr Ile Lys 
    1085                 1090                 1095             


Glu Lys  Ser Glu Phe Val Gln  Tyr Cys Phe Phe Ile  Ile Leu Ile 
    1100                 1105                 1110             


Arg Asn  Lys Phe Ala His Asn  Gln Phe Ile Glu Ala  Thr Tyr Met 
    1115                 1120                 1125             


His Tyr  Leu Met Ser Lys Met  Val Ile Asn Pro Asp  Tyr Ser Tyr 
    1130                 1135                 1140             


Cys Glu  Asn Ile Ser Glu Phe  Leu Lys Ser Ala Thr  Ser Lys Ile 
    1145                 1150                 1155             


Leu Asn  His Leu Asn Tyr Lys  Asn Val His 
    1160                 1165             


<210>  1957
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1957

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Leu Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1958
<211>  985
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1958

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Asn Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys Gly Tyr 
                165                 170                 175     


Ala Phe Phe Ile Ser Lys Phe Leu Glu Arg Lys Tyr Ser Tyr Leu Phe 
            180                 185                 190         


Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln Tyr Arg 
        195                 200                 205             


Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro Val Glu 
    210                 215                 220                 


Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu Asp Ile 
225                 230                 235                 240 


Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr Leu Glu 
                245                 250                 255     


Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr Asp Ala 
            260                 265                 270         


Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe Arg Ser 
        275                 280                 285             


Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala Asp Phe 
    290                 295                 300                 


Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His Asn Gly 
305                 310                 315                 320 


Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr Ile Asn 
                325                 330                 335     


Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser Ala Lys 
            340                 345                 350         


Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser Thr Asp 
        355                 360                 365             


Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln Ser Thr 
    370                 375                 380                 


Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val Leu Pro 
385                 390                 395                 400 


Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala Lys Met 
                405                 410                 415     


Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala Met Leu 
            420                 425                 430         


Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His Cys Pro 
        435                 440                 445             


Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser Thr Lys 
    450                 455                 460                 


Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg Val Met 
465                 470                 475                 480 


Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu Arg Ile 
                485                 490                 495     


Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile Leu Lys 
            500                 505                 510         


Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp Leu Gln 
        515                 520                 525             


Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn Phe Gln 
    530                 535                 540                 


Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn Asp Leu 
545                 550                 555                 560 


Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn Pro His 
                565                 570                 575     


Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile Glu Phe 
            580                 585                 590         


Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg Ile Gln 
        595                 600                 605             


Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro Leu Arg 
    610                 615                 620                 


Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu Ala Ile 
625                 630                 635                 640 


Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys Leu Lys 
                645                 650                 655     


Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu Lys Ser 
            660                 665                 670         


Pro Ala Leu Asn Val Ser Tyr Leu Ile His Asn Tyr Phe Arg Ala Tyr 
        675                 680                 685             


Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn Tyr Arg 
    690                 695                 700                 


Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser Tyr Leu 
705                 710                 715                 720 


Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro Ser Lys 
                725                 730                 735     


Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp Arg Leu 
            740                 745                 750         


Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile Ile Arg 
        755                 760                 765             


Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys Glu Tyr 
    770                 775                 780                 


Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu Glu Asn 
785                 790                 795                 800 


Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp Leu Asn 
                805                 810                 815     


Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr Gly Lys 
            820                 825                 830         


Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn Lys Val 
        835                 840                 845             


Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val Lys Ile 
    850                 855                 860                 


Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu Glu Ala 
865                 870                 875                 880 


Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala Met Val 
                885                 890                 895     


Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr Tyr Asp 
            900                 905                 910         


Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln Lys Ile 
        915                 920                 925             


Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His Asp Lys 
    930                 935                 940                 


Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val Tyr Ala 
945                 950                 955                 960 


Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile Lys Leu 
                965                 970                 975     


Glu Asp Leu Ser Asn Asp Ser Ser Ala 
            980                 985 


<210>  1959
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1959

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Leu Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1960
<211>  1157
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1960

Met Glu Asn Ile Glu Thr Lys Lys Asp Asn Lys Lys Thr Leu Asn Val 
1               5                   10                  15      


Asn Pro Glu Phe Phe Gly Thr Tyr Leu Asn Leu Ala Arg His Asn Val 
            20                  25                  30          


Phe Leu Ile Asn Asn Glu Leu Ala Asn Arg Phe Glu Ile Asn Ser Ile 
        35                  40                  45              


Leu Thr Thr Asp Glu Asn Ile Gly Ser Ser Phe Met Thr Asn Lys Ile 
    50                  55                  60                  


Thr Phe Asp Lys Thr Asn Ser Asn Leu Val Tyr Thr Asn Leu Val Arg 
65                  70                  75                  80  


Tyr Met Pro Val Ala Lys Ile Phe Ser Ser Asp Leu Leu Pro Lys Lys 
                85                  90                  95      


Ile Gln Glu Phe Ala Thr Phe Gln Gly Val Asp Ile Leu Lys Leu Thr 
            100                 105                 110         


Gln Phe Phe Lys Leu Ser Phe Ser Glu Leu Asn Ser Phe Arg Asn Asp 
        115                 120                 125             


Tyr Ser His Tyr Tyr Ser Ile Glu Thr Lys Thr Leu Lys Lys Thr Gln 
    130                 135                 140                 


Ile Ser Ala Asp Phe Ala Pro Leu Phe Lys Glu Ser Phe Ala Phe Ala 
145                 150                 155                 160 


Ile Glu Phe Ala Lys Ser Arg Phe Glu Thr Ile Phe Asp Lys Lys Asp 
                165                 170                 175     


Phe Glu Leu Val Glu Lys Met Glu Leu Ile Asp Ser Asn Asn Thr Ile 
            180                 185                 190         


Ser Asp Arg Gly Val Val Phe Leu Ala Cys Met Phe Leu Asp Lys Glu 
        195                 200                 205             


Asn Ala Phe Gln Phe Met Asn Lys Val Val Gly Phe Lys Ala Thr Asn 
    210                 215                 220                 


Asp Asn Ile Phe Leu Ala Thr Arg Glu Val Phe Ser Val Phe Cys Val 
225                 230                 235                 240 


Thr Leu Pro His Asp Lys Phe Leu Ser Asp Asn Pro Lys Gln Ala Leu 
                245                 250                 255     


Gln Leu Asp Met Leu Asn Tyr Leu Asn Arg Cys Pro Lys Glu Leu Phe 
            260                 265                 270         


Asn Ala Leu Ser Pro Ile Gly Lys Lys Gln Phe Gln Pro Asn Leu Ser 
        275                 280                 285             


Ala Ile Ala Ser Leu Asn Val Glu Asp Asn Ser Ile Asn Glu Ser Ile 
    290                 295                 300                 


Asp Phe Glu Asn Tyr Gln Asn Tyr Ile Glu Asn Ile Ser Thr Lys Lys 
305                 310                 315                 320 


Arg Ser Ser Asp Arg Phe Pro Tyr Phe Ala Leu Lys His Leu Ser Glu 
                325                 330                 335     


Asn Asn Lys Phe Asp Phe Asp Phe Gln Ile Asn Leu Gly Lys Val Leu 
            340                 345                 350         


Lys Lys Ser Tyr Lys Lys Val Val Leu Gly Ile Glu Pro Glu Glu Asn 
        355                 360                 365             


Asn Arg Asn Ile Val Glu Asn Ile Leu Val Phe Asn Asn Ile Ser Ile 
    370                 375                 380                 


Phe Glu Asn Lys Asn Asp Asp Glu Ile Leu Glu Ile Lys Lys Ser Ile 
385                 390                 395                 400 


Ile Asn Glu Pro Thr Phe Ile Lys Arg Phe Ser Asn Ile Asp Val Ser 
                405                 410                 415     


Asp Phe Glu Gln Phe Thr Pro His Phe Asn Thr Glu Asn Asn Lys Ile 
            420                 425                 430         


Gly Leu Leu Pro His Asp Asn Lys Met Phe Ala Asn Leu Leu Tyr Arg 
        435                 440                 445             


Pro Ile Val Pro Thr Ala Phe Leu Ser Thr His Glu Leu Pro Lys Val 
    450                 455                 460                 


Val Leu Leu Glu His Leu Glu Lys Gly Ser Ser Ser Gln Ile Ile Lys 
465                 470                 475                 480 


Ser Phe Ile Asp Ala Asn Thr Asn Val Ile Phe Asn Lys Ser Leu Val 
                485                 490                 495     


Glu Glu Ile Lys Glu Lys Leu Ala Phe Glu Arg Thr Leu Tyr Lys Val 
            500                 505                 510         


Phe Phe Asp Glu Lys Leu Lys Val Leu Asp Trp Lys Ala Asp Leu Glu 
        515                 520                 525             


Thr Gln Leu Asn Ser Leu Asn Asp Ser Ile Lys Lys Leu Lys Glu Thr 
    530                 535                 540                 


Gln Thr Val Thr Phe Asp Glu Lys Arg Asn Lys Asp Asn Ala Leu Lys 
545                 550                 555                 560 


Asn Lys Gln Phe Glu Arg Lys Ser Leu Asn Tyr Ala Leu Tyr Val Lys 
                565                 570                 575     


Arg Val Asn Glu Arg Lys Asn Ile Leu Asn Asn Val Leu Glu Lys Tyr 
            580                 585                 590         


Asn Leu Asp Ala Ser Gln Ile Pro Ser Ala Ile Ile Asp Tyr Trp Leu 
        595                 600                 605             


Lys Ile Asp Ser Val Lys Glu Glu Thr Thr Ile Lys Asn Lys Ile Arg 
    610                 615                 620                 


Ala Glu Lys Ser Glu Cys Arg Asp Arg Leu Lys Asp Ile Lys Asn Gly 
625                 630                 635                 640 


Lys Ser Pro Lys Ile Gly Glu Met Ala Thr Phe Leu Ala Arg Asp Ile 
                645                 650                 655     


Val Arg Leu Val Ile Asp Lys Asp Val Lys Lys Lys Ile Thr Ser Phe 
            660                 665                 670         


Tyr Tyr Asp Lys Leu Gln Glu Cys Leu Ala Leu Tyr Glu Asp Lys Asp 
        675                 680                 685             


Lys Lys Gln Leu Phe Ile Asp Leu Cys Asn Lys Glu Leu Gln Leu Phe 
    690                 695                 700                 


Asp Asn Gln Lys Gly His Pro Phe Leu Ser Asn Leu Asn Leu Gln Asp 
705                 710                 715                 720 


Ile His Arg Thr Lys Glu Leu Tyr Gln Lys Tyr Ile Glu Glu Lys Gly 
                725                 730                 735     


Glu Lys Thr Val Pro Glu Lys Tyr Tyr Asn Arg Lys Ser Asp Asn Trp 
            740                 745                 750         


Glu Phe Lys Glu Ile Glu Ala Asn Trp Met Tyr Lys Thr Phe Tyr Asn 
        755                 760                 765             


Lys Val Lys Asn Ile Glu Thr Gly Lys Asp Glu Thr Gln Ile Thr Ile 
    770                 775                 780                 


Pro Ile Asn Lys Pro Met Pro Ile Val Tyr Ser Lys Leu Leu Asp Lys 
785                 790                 795                 800 


Thr Asn Asp Phe Asp Lys Trp Phe Thr Asn Val Ser Ser Gly Cys Ile 
                805                 810                 815     


Thr Pro Glu Asn Pro Lys Pro Asn Pro Lys Pro Ile Asp Leu Pro Thr 
            820                 825                 830         


Asn Leu Phe Asp Asp Lys Leu Val Lys Leu Leu Lys Asn Lys Ile Gly 
        835                 840                 845             


Ile Ala Asp Asn Asp Thr Thr Val Tyr Asn Phe Ser Lys Leu Leu Glu 
    850                 855                 860                 


Met Trp Leu Ala Asp Ala Gln Pro Phe Tyr Asp Asn Asp Arg Glu Tyr 
865                 870                 875                 880 


Ile Val Phe Lys Asn Lys Pro Phe Glu Ala Ile Val Pro Ile Lys Leu 
                885                 890                 895     


Gly Thr Lys Asn Ser Phe Lys Asp Tyr Tyr Arg Glu Phe Val Glu Thr 
            900                 905                 910         


Thr Phe Arg Leu Lys Lys Gln Glu Ser Lys Gln Leu Gln Lys Ser Gln 
        915                 920                 925             


Val Glu Ala Val Phe Arg Asn Ala Ile Ser Glu Asn Glu Lys Ile Ile 
    930                 935                 940                 


Arg His Tyr Lys Thr Lys Asp Arg Ile Met Leu Leu Met Leu Lys Glu 
945                 950                 955                 960 


Thr Leu Thr Ala Asp Ile Asp Ile Lys Leu Ser Glu Ile Tyr Pro Lys 
                965                 970                 975     


Ser Leu Thr Asn Pro Leu Asp Ile Gln Ile Pro Ile Lys Gln Pro Ile 
            980                 985                 990         


Gly Asn Lys Phe Ile Thr Asp Thr  Arg Lys Arg Lys Glu  Tyr Ser Ile 
        995                 1000                 1005             


Phe Lys  Arg Tyr Leu Ser Asp  Arg Arg Leu Pro Ser  Leu Leu Thr 
    1010                 1015                 1020             


Tyr Phe  Asp Thr Val Glu Ile  Pro Phe Glu Thr Leu  Lys Leu Glu 
    1025                 1030                 1035             


Leu Asn  Asp Tyr Gln Thr Ser  Arg Ile Ser Ile Ala  Glu Ala Val 
    1040                 1045                 1050             


Phe Lys  Leu Glu Lys Ser Ile  Ile Asn Val Val Ser  Gln Gln Asp 
    1055                 1060                 1065             


Leu Gln  Glu Leu Glu Ser His  Ala Thr Glu Lys Ile  Ser Asn Ile 
    1070                 1075                 1080             


Gln Phe  Lys His Tyr Cys Asn  Trp Leu Ile Lys Asn  Glu Lys Ile 
    1085                 1090                 1095             


Asn Pro  Gln Gln Gln Leu Phe  Leu Glu Asn Val Arg  Asn Lys Phe 
    1100                 1105                 1110             


Leu His  Asn Gln Phe Pro Asp  Arg Glu Ile Val Glu  Gln His Leu 
    1115                 1120                 1125             


Gln Leu  Glu Gln Asn Ser Thr  Phe Ser Lys Gln Ile  Ala Asn His 
    1130                 1135                 1140             


Tyr Leu  Ser Ile Ile Glu Asn  Leu Ile Thr Asn Lys  Phe Asn 
    1145                 1150                 1155         


<210>  1961
<211>  985
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1961

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Asn Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys Gly Tyr 
                165                 170                 175     


Ala Phe Phe Ile Ser Lys Phe Leu Glu Arg Lys Tyr Ser Tyr Leu Phe 
            180                 185                 190         


Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln Tyr Arg 
        195                 200                 205             


Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro Val Glu 
    210                 215                 220                 


Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu Asp Ile 
225                 230                 235                 240 


Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr Leu Glu 
                245                 250                 255     


Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr Asp Ala 
            260                 265                 270         


Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe Arg Ser 
        275                 280                 285             


Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala Asp Phe 
    290                 295                 300                 


Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His Asn Gly 
305                 310                 315                 320 


Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr Ile Asn 
                325                 330                 335     


Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser Ala Lys 
            340                 345                 350         


Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser Thr Asp 
        355                 360                 365             


Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln Ser Thr 
    370                 375                 380                 


Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val Leu Pro 
385                 390                 395                 400 


Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala Lys Met 
                405                 410                 415     


Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala Met Leu 
            420                 425                 430         


Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His Cys Pro 
        435                 440                 445             


Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser Thr Lys 
    450                 455                 460                 


Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg Val Met 
465                 470                 475                 480 


Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu Arg Ile 
                485                 490                 495     


Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile Leu Lys 
            500                 505                 510         


Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp Leu Gln 
        515                 520                 525             


Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn Phe Gln 
    530                 535                 540                 


Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn Asp Leu 
545                 550                 555                 560 


Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn Pro His 
                565                 570                 575     


Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile Glu Phe 
            580                 585                 590         


Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg Ile Gln 
        595                 600                 605             


Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro Leu Arg 
    610                 615                 620                 


Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu Ala Ile 
625                 630                 635                 640 


Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys Leu Lys 
                645                 650                 655     


Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu Lys Ser 
            660                 665                 670         


Pro Ala Leu Asn Val Ser Tyr Leu Ile His Asn Tyr Phe Arg Ala Tyr 
        675                 680                 685             


Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn Tyr Arg 
    690                 695                 700                 


Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser Tyr Leu 
705                 710                 715                 720 


Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro Ser Lys 
                725                 730                 735     


Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp Arg Leu 
            740                 745                 750         


Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile Ile Arg 
        755                 760                 765             


Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys Glu Tyr 
    770                 775                 780                 


Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu Glu Asn 
785                 790                 795                 800 


Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp Leu Asn 
                805                 810                 815     


Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr Gly Lys 
            820                 825                 830         


Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn Lys Val 
        835                 840                 845             


Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val Lys Ile 
    850                 855                 860                 


Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu Glu Ala 
865                 870                 875                 880 


Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala Met Val 
                885                 890                 895     


Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr Tyr Asp 
            900                 905                 910         


Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln Lys Ile 
        915                 920                 925             


Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His Asp Lys 
    930                 935                 940                 


Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val Tyr Ala 
945                 950                 955                 960 


Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile Lys Leu 
                965                 970                 975     


Glu Asp Leu Ser Asn Asp Ser Ser Ala 
            980                 985 


<210>  1962
<211>  1110
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1962

Met Glu Thr Asn Glu Gln Ile Leu Glu Asn Arg Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Ser Asn His Ile Ala Asn Glu Phe Gly Gln Ala Pro 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ala Ser Phe Leu Cys Asn Lys Gly 
    50                  55                  60                  


Ile Lys Lys Leu Asn Trp Asn His Val Tyr Gly Lys Thr Arg Arg Phe 
65                  70                  75                  80  


Leu Ser Ile Leu Lys Val Phe Asp Val Glu Ser Leu Pro Lys Asp Glu 
                85                  90                  95      


Arg Glu Asn Ser Glu Lys Glu Gly Arg Asp Phe Ala Ser Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Gly Glu Leu Gln Ala Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Asp Ser Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Val Glu Leu Ala Asp Phe Leu Thr Val Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Ala Asp Ile Asp Tyr 
                165                 170                 175     


Glu Leu Val Glu Ser Lys His Ile Val Thr Pro Asp Asn Thr Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asp Leu Arg Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Glu 
            260                 265                 270         


Val Ile Thr Glu Glu Ser Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Ser Asn Asp Glu Glu Arg 
    290                 295                 300                 


Glu Lys Ile Leu Asp Glu Ile Glu Tyr Glu Asp Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg His Asn Asn Arg Phe Pro Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe Gln Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Lys Tyr Asn Lys Glu Leu Asn Gly Glu 
        355                 360                 365             


Pro Ile Glu Arg Val Val Val Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Tyr Val Asp Glu Lys Thr Ile Ala Lys Lys Ile Asp Asn Gln 
385                 390                 395                 400 


Gln Arg Thr Gly Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Glu Thr Ala Val Leu Ile 
            420                 425                 430         


Pro Lys Thr Lys Pro Asp Ser Lys Val Ser Asn Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Lys Ala Glu Glu Met Ile His Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Ser Lys Leu Met Asn Met His Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Ser Lys Leu Pro Ala Asp Trp Asn Glu Phe Ala Lys Arg Ser 
            500                 505                 510         


Asp Ser Lys Lys Lys Lys Ala Tyr Ser Glu Ala Ala Leu Lys Tyr Leu 
        515                 520                 525             


Trp Gln Arg Lys Thr Ile Leu Asn Asp Val Leu Ile Glu Tyr Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Val Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Glu Asp Asn Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Thr Arg Leu Lys Val Leu Glu Lys His Lys Leu 
            580                 585                 590         


Asp Lys Ser Val Lys Thr Pro Lys Val Gly Glu Met Ala Thr Tyr Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Lys Glu Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Ala Asp Ala Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Phe Glu Asn Gly Gly His Pro Phe Leu Gln Asn Leu Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Glu Ala Tyr Leu Lys 
        675                 680                 685             


Glu Lys Gly Asn Lys Gln Val Gln Lys Phe Asn Pro Lys Thr Asn Lys 
    690                 695                 700                 


Thr Ser Lys Ile Asp Glu Ser Trp Met Met Gln Leu Phe Tyr Ser Lys 
705                 710                 715                 720 


Glu Trp Lys Glu Glu Ile Gly Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Ile His Val Pro Phe Thr Ile Arg Met Trp Glu Glu Lys 
            740                 745                 750         


Glu Lys Tyr Asn Leu Asn Ala Trp Leu His Asn Val Ala Val Gly Lys 
        755                 760                 765             


Asn Val Lys Asp Gly Lys Lys Ala Val Asp Leu Pro Thr Asn Leu Phe 
    770                 775                 780                 


Asp Glu Thr Leu Cys Asp Leu Leu Arg Lys Gln Leu Asp Ala Lys Thr 
785                 790                 795                 800 


Val Asn Tyr Asn Pro Ala Ser Asn Tyr Asn Glu Leu Leu Lys Leu Trp 
                805                 810                 815     


Trp Ile Thr Arg Asp Asp Ala Thr Gln Asp Phe Tyr Gln Ser Glu Arg 
            820                 825                 830         


Glu Tyr Glu Ile Tyr Lys Glu Lys Leu Lys Phe Asn Leu Asp Ser Ser 
        835                 840                 845             


Ser His Phe Ala Asp Tyr Phe Lys Lys Ala Leu Glu Arg Ala Tyr Asn 
    850                 855                 860                 


Arg Leu Lys Ala Glu Arg Glu Thr Glu Gln Gln Thr Asn Arg Arg Leu 
865                 870                 875                 880 


Pro Pro Ile Asp Pro Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile 
                885                 890                 895     


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
            900                 905                 910         


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asn Thr Arg Asn Leu Lys 
        915                 920                 925             


Leu Ser Lys Ile Lys Thr Leu Leu Asn Asp Thr Thr Arg Ile Glu His 
    930                 935                 940                 


Lys Ile Leu Asn Lys Thr Ile Ile Ala Glu Arg Lys Gln Lys Asn Tyr 
945                 950                 955                 960 


Thr Glu Leu Arg Lys Tyr Val His Asp Arg Arg Leu Pro Asp Leu Phe 
                965                 970                 975     


Glu Tyr Val Asp Ala Asp Glu Val Pro Leu Glu Trp Leu Gln Asp Glu 
            980                 985                 990         


Leu Arg Ala Tyr Asn Thr Ala Lys  Gln Gln Val Phe Asp  Thr Val Phe 
        995                 1000                 1005             


Met Leu  Glu Lys Lys Ile Ile  Glu Thr Asp Tyr Val  Gly Leu Lys 
    1010                 1015                 1020             


Val Leu  Phe Thr Gly Pro Asp  Gly Gln Val Gln Thr  Gly Asn Ile 
    1025                 1030                 1035             


Gln His  Lys Pro Tyr Leu Gln  Trp Leu Lys Asn Lys  Gly Leu Ile 
    1040                 1045                 1050             


Asn Asp  Asn Glu Lys Gln Phe  Ile Asn Glu Val Arg  Asn Cys Phe 
    1055                 1060                 1065             


Ser His  Asn Gln Phe Pro Gln  Arg Lys Thr Met Glu  Leu Leu Ile 
    1070                 1075                 1080             


Leu Gly  Trp Glu Glu Gly Lys  Leu Ala Leu Gln Ile  Val Thr Val 
    1085                 1090                 1095             


Tyr Asn  Gln Leu Ile Thr Asp  Ile Ile Asp Arg Ile  
    1100                 1105                 1110 


<210>  1963
<211>  985
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1963

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Asn Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys Gly Tyr 
                165                 170                 175     


Ala Phe Phe Ile Ser Lys Phe Leu Glu Arg Lys Tyr Ser Tyr Leu Phe 
            180                 185                 190         


Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln Tyr Arg 
        195                 200                 205             


Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro Val Glu 
    210                 215                 220                 


Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu Asp Ile 
225                 230                 235                 240 


Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr Leu Glu 
                245                 250                 255     


Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr Asp Ala 
            260                 265                 270         


Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe Arg Ser 
        275                 280                 285             


Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala Asp Phe 
    290                 295                 300                 


Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His Asn Gly 
305                 310                 315                 320 


Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr Ile Asn 
                325                 330                 335     


Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser Ala Lys 
            340                 345                 350         


Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser Thr Asp 
        355                 360                 365             


Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln Ser Thr 
    370                 375                 380                 


Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val Leu Pro 
385                 390                 395                 400 


Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala Lys Met 
                405                 410                 415     


Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala Met Leu 
            420                 425                 430         


Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His Cys Pro 
        435                 440                 445             


Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser Thr Lys 
    450                 455                 460                 


Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg Val Met 
465                 470                 475                 480 


Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu Arg Ile 
                485                 490                 495     


Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile Leu Lys 
            500                 505                 510         


Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp Leu Gln 
        515                 520                 525             


Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn Phe Gln 
    530                 535                 540                 


Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn Asp Leu 
545                 550                 555                 560 


Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn Pro His 
                565                 570                 575     


Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile Glu Phe 
            580                 585                 590         


Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg Ile Gln 
        595                 600                 605             


Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro Leu Arg 
    610                 615                 620                 


Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu Ala Ile 
625                 630                 635                 640 


Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys Leu Lys 
                645                 650                 655     


Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu Lys Ser 
            660                 665                 670         


Pro Ala Leu Asn Val Ser Tyr Leu Ile His Asn Tyr Phe Arg Ala Tyr 
        675                 680                 685             


Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn Tyr Arg 
    690                 695                 700                 


Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser Tyr Leu 
705                 710                 715                 720 


Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro Ser Lys 
                725                 730                 735     


Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp Arg Leu 
            740                 745                 750         


Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile Ile Arg 
        755                 760                 765             


Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys Glu Tyr 
    770                 775                 780                 


Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu Glu Asn 
785                 790                 795                 800 


Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp Leu Asn 
                805                 810                 815     


Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr Gly Lys 
            820                 825                 830         


Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn Lys Val 
        835                 840                 845             


Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val Lys Ile 
    850                 855                 860                 


Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu Glu Ala 
865                 870                 875                 880 


Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala Met Val 
                885                 890                 895     


Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr Tyr Asp 
            900                 905                 910         


Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln Lys Ile 
        915                 920                 925             


Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His Asp Lys 
    930                 935                 940                 


Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val Tyr Ala 
945                 950                 955                 960 


Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile Lys Leu 
                965                 970                 975     


Glu Asp Leu Ser Asn Asp Ser Ser Ala 
            980                 985 


<210>  1964
<211>  1136
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1964

Met Glu Ser His Val Asn Asn Pro Lys Lys Arg Thr Leu Ala Asp Asp 
1               5                   10                  15      


Pro Gln Tyr Phe Gly Ala Phe Leu Asn Met Ala Arg His Asn Val Phe 
            20                  25                  30          


Leu Ile Ile Asn His Ile Ile Gly His Phe Pro Asn Gln Lys Pro Ile 
        35                  40                  45              


Lys Asp Asp Asp Gln Ile Ala Asn Glu Pro Leu Asn Phe Ile Val Asn 
    50                  55                  60                  


Arg Asn Lys Tyr Ser Ala Ser Asp Thr Gln Lys Leu Phe Asp Leu Leu 
65                  70                  75                  80  


Gln Lys Phe Met Pro Val Val Lys Val Phe Asn Pro Glu Ala Leu Pro 
                85                  90                  95      


Lys Asn Glu Arg Ser Ala Asp Ser Ile Asp Phe Asp Gly Phe Phe Glu 
            100                 105                 110         


Ile Ile Asn Lys Cys Phe Lys Glu Leu Asn His Phe Arg Asn Asp Tyr 
        115                 120                 125             


Leu His Tyr Tyr Ser Val Asp Asn Lys Asp Glu Arg Lys Ile Ser Ile 
    130                 135                 140                 


Asp Glu Asp Leu Ala Gly Phe Leu Ser Thr Gly Phe Gln Arg Ala Val 
145                 150                 155                 160 


Glu Tyr Thr Met Asn Arg Phe Lys Asp Thr Phe Glu Glu Lys Asp Phe 
                165                 170                 175     


Glu Ile Ala Lys Glu Lys Ile Ile Val Thr Glu Asp Asn Val Ile Thr 
            180                 185                 190         


Pro Asp Gly Leu Val Phe Phe Cys Cys Leu Phe Leu Asp Arg Glu Tyr 
        195                 200                 205             


Ala Phe Gln Phe Ile Asn Arg Val Val Gly Phe Lys Gly Thr Gln His 
    210                 215                 220                 


Lys Val Phe Leu Ala Thr Arg Ala Val Phe Ser Ala Tyr Cys Val Lys 
225                 230                 235                 240 


Leu Pro Tyr Glu Lys Leu Ile Ser Asp Asp Pro Arg Gln Ala Phe Leu 
                245                 250                 255     


Leu Asp Met Leu Asn Glu Leu Asn Arg Cys Pro Asp Glu Leu Phe Arg 
            260                 265                 270         


Cys Leu Gly Asn Glu Gly Lys Lys Gln Phe Gln Pro Asn Leu Asp Val 
        275                 280                 285             


Leu Glu Lys Leu Glu Ile Glu Asn Phe Asp Glu Tyr Ile Gln Asn Ile 
    290                 295                 300                 


Thr Thr Lys Lys Arg Tyr Arg Asp Arg Phe Pro Tyr Phe Ala Met Lys 
305                 310                 315                 320 


Tyr Phe Asp Met Asn Asn Cys Phe Glu Lys Leu Arg Phe His Ile Asn 
                325                 330                 335     


Leu Gly Lys Tyr His Val Thr Glu Tyr Glu Lys Ser Phe Asn Asn Ser 
            340                 345                 350         


Thr Glu Asp Arg Val Ile Ile Glu Asn Val Lys Thr Phe Gly Lys Leu 
        355                 360                 365             


Glu Glu Tyr Ala Leu Pro Glu Glu Glu Lys Glu Lys Leu Ile Lys Lys 
    370                 375                 380                 


Ile Glu Asp Lys Ile Asn Leu Val Thr Ser Lys Asn Ser Phe Phe Glu 
385                 390                 395                 400 


Gln Phe Ser Pro His Tyr His Ile Glu Lys Asn Lys Ile Gly Leu Gln 
                405                 410                 415     


Phe Lys Ser Asp Val Pro Glu Ile Lys Lys Tyr Ile Gly Lys Lys Leu 
            420                 425                 430         


Tyr Asn Lys Pro Gly Ile Pro Asn Ile Thr Gln Ile Pro Tyr Leu Ile 
        435                 440                 445             


Lys Ser Asp Ser Asn Thr Ser Arg Ile Asn Leu Lys Leu Asn Lys Ala 
    450                 455                 460                 


His Pro Asp Ala Phe Leu Ser Ile His Gln Leu Pro Lys Met Val Leu 
465                 470                 475                 480 


Ile Glu Leu Leu Glu Lys Gly Ser Ser Glu Lys Ile Ile Lys Glu Phe 
                485                 490                 495     


Ile Asn Asn Ser Phe Pro Lys Ile Leu Glu Ser Glu Ile Ile Lys Asp 
            500                 505                 510         


Val Lys Lys Gln Leu Asn Ile Glu Lys Pro Phe Tyr Lys Lys Phe Gln 
        515                 520                 525             


Gly Lys Ser Lys Asn Ala Tyr Thr Ser Glu Ala Leu Glu Ile Leu Ala 
    530                 535                 540                 


Glu Arg Lys Glu Arg Leu Asn Glu Leu Leu Lys Pro Tyr Lys Leu Asp 
545                 550                 555                 560 


Thr Lys Gln Ile Pro Thr Arg Leu Ile Asn Tyr Phe Leu Asp Ile Lys 
                565                 570                 575     


Glu Val Ser Gln Asn Leu Ser Ile Lys Asn Val Ile Lys Asn His Val 
            580                 585                 590         


Glu Asp Ile Lys Asn Arg Leu Lys Asp Ile Asn Lys Asn Lys Ser Pro 
        595                 600                 605             


Arg Ile Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile Val Asp Met 
    610                 615                 620                 


Met Ile Asp Glu Asn Gln Lys Lys Lys Phe Thr Ser Phe Tyr Tyr Asp 
625                 630                 635                 640 


Lys Leu Gln Arg Ser Ile Ala Leu Phe Pro Ser Ala Glu Asp Gly Lys 
                645                 650                 655     


Ile Val Phe Ile Asn Ile Cys Ser Lys Glu Phe Asp Leu Phe Asn Lys 
            660                 665                 670         


Glu Met Gly His Pro Phe Leu Gln Asp Ile Arg Ile Ser Asp Phe Tyr 
        675                 680                 685             


Lys Thr Phe Asp Leu Tyr Lys Ala Tyr Leu Glu Leu Lys Ile Gln Trp 
    690                 695                 700                 


Val Lys Arg Val Phe Tyr Ser Glu Lys Ile Asn Lys Lys Lys Ser Arg 
705                 710                 715                 720 


Leu Glu Thr Tyr Ile Ser Ile Pro Glu Asn Gln His Ser Ile Pro Phe 
                725                 730                 735     


Ser Phe Trp Asn Leu Gln Lys Glu Gln Ser Ser Phe Glu Glu Trp Leu 
            740                 745                 750         


Gly Asn Ile Lys Gly Glu Lys Glu Ser Arg Gln Lys Pro Val Asp Leu 
        755                 760                 765             


Pro Val Asn Leu Phe Asp Asn Lys Ala Glu Asp Leu Leu Lys Ser Lys 
    770                 775                 780                 


Leu Arg Glu Lys Asn Ile Val Tyr Gly Glu Ser Asp Arg Phe Ala Arg 
785                 790                 795                 800 


Leu Leu Glu Leu Tyr Phe Glu Lys Asp Ile Gln Pro Phe Tyr Lys Asn 
                805                 810                 815     


Lys Arg Glu Tyr Asn Ile Tyr Glu Glu Ile Ile Pro Phe Glu Leu Gln 
            820                 825                 830         


Asp Asn Val Lys Phe Lys Asp Leu Phe Tyr Asn Lys Ala Leu Glu Ile 
        835                 840                 845             


Tyr Asn Lys Lys Thr Ile Glu Arg Lys Glu Glu Asn Asp Ala Ile Lys 
    850                 855                 860                 


Ile Arg Asn Lys Ser Lys Lys Tyr Asn Lys Glu Lys Thr Lys Pro Pro 
865                 870                 875                 880 


Leu Lys Phe Asp Asp Ile Leu Asn Val Phe Asn Asn Ala Ile Thr Glu 
                885                 890                 895     


Asn Glu Lys Leu Leu Arg Phe Tyr Gln Val Lys Asp Arg Leu Met Leu 
            900                 905                 910         


Lys Met Cys Glu Asn Leu Ile Glu Cys Asp Glu Pro Leu Asn Phe Lys 
        915                 920                 925             


Leu Glu Glu Ile Tyr Pro Gly Ser Glu Ile Ser Pro Leu Glu Ile Glu 
    930                 935                 940                 


Ser Glu Ile Thr Gln Lys Val Thr Gly Glu Leu Ser Phe Asp Glu Lys 
945                 950                 955                 960 


Gly Asn Arg Ile Asn Leu Asp Ser Lys Val Lys Ile Asp Lys Thr Val 
                965                 970                 975     


Thr Ala Thr Arg Lys Arg Lys Asp Phe Gly Val Phe Lys Lys Phe Ile 
            980                 985                 990         


His Asp Lys Arg Leu Pro Glu Leu  Phe Glu Tyr Phe Asp  Glu Gln Gln 
        995                 1000                 1005             


Ile Pro  Tyr Glu Thr Leu Lys  Ile Glu Leu Ala Asp  Tyr Asn Phe 
    1010                 1015                 1020             


Ala Lys  Glu Leu Ile Leu Asp  Lys Thr Phe Glu Leu  Glu Lys Arg 
    1025                 1030                 1035             


Val Ile  Tyr Cys Phe Asn Asp  Glu Phe Leu Asp Trp  Tyr Lys Thr 
    1040                 1045                 1050             


Ile Met  Glu Ser Asp Ile His  Asn Ile Gln Phe Lys  Tyr Tyr Leu 
    1055                 1060                 1065             


Asp Phe  Leu Lys Ser Lys Asn  Ile Met Lys Pro Asp  Glu Tyr Asp 
    1070                 1075                 1080             


Phe Leu  Lys Val Val Arg Asn  Thr Phe Ser His Asn  Gln Phe Pro 
    1085                 1090                 1095             


Pro Lys  Ala Val Met Glu Arg  Phe Ile Pro Ile Asn  Lys Ser Asn 
    1100                 1105                 1110             


Gly Lys  Ile Ser Gly Gln Val  Tyr Glu Lys Tyr Asn  Glu Lys Ile 
    1115                 1120                 1125             


Glu Asn  Val Leu Cys Gln Phe  Val 
    1130                 1135     


<210>  1965
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1965

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Ala Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Leu Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1966
<211>  985
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1966

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Asn Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys Gly Tyr 
                165                 170                 175     


Ala Phe Phe Ile Ser Lys Phe Leu Glu Arg Lys Tyr Ser Tyr Leu Phe 
            180                 185                 190         


Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln Tyr Arg 
        195                 200                 205             


Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro Val Glu 
    210                 215                 220                 


Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu Asp Ile 
225                 230                 235                 240 


Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr Leu Glu 
                245                 250                 255     


Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr Asp Ala 
            260                 265                 270         


Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe Arg Ser 
        275                 280                 285             


Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala Asp Phe 
    290                 295                 300                 


Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His Asn Gly 
305                 310                 315                 320 


Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr Ile Asn 
                325                 330                 335     


Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser Ala Lys 
            340                 345                 350         


Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser Thr Asp 
        355                 360                 365             


Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln Ser Thr 
    370                 375                 380                 


Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val Leu Pro 
385                 390                 395                 400 


Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala Lys Met 
                405                 410                 415     


Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala Met Leu 
            420                 425                 430         


Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His Cys Pro 
        435                 440                 445             


Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser Thr Lys 
    450                 455                 460                 


Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg Val Met 
465                 470                 475                 480 


Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu Arg Ile 
                485                 490                 495     


Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile Leu Lys 
            500                 505                 510         


Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp Leu Gln 
        515                 520                 525             


Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn Phe Gln 
    530                 535                 540                 


Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn Asp Leu 
545                 550                 555                 560 


Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn Pro His 
                565                 570                 575     


Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile Glu Phe 
            580                 585                 590         


Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg Ile Gln 
        595                 600                 605             


Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro Leu Arg 
    610                 615                 620                 


Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu Ala Ile 
625                 630                 635                 640 


Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys Leu Lys 
                645                 650                 655     


Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu Lys Ser 
            660                 665                 670         


Pro Ala Leu Asn Val Ser Tyr Leu Ile His Asn Tyr Phe Arg Ala Tyr 
        675                 680                 685             


Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn Tyr Arg 
    690                 695                 700                 


Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser Tyr Leu 
705                 710                 715                 720 


Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro Ser Lys 
                725                 730                 735     


Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp Arg Leu 
            740                 745                 750         


Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile Ile Arg 
        755                 760                 765             


Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys Glu Tyr 
    770                 775                 780                 


Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu Glu Asn 
785                 790                 795                 800 


Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp Leu Asn 
                805                 810                 815     


Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr Gly Lys 
            820                 825                 830         


Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn Lys Val 
        835                 840                 845             


Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val Lys Ile 
    850                 855                 860                 


Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu Glu Ala 
865                 870                 875                 880 


Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala Met Val 
                885                 890                 895     


Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr Tyr Asp 
            900                 905                 910         


Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln Lys Ile 
        915                 920                 925             


Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His Asp Lys 
    930                 935                 940                 


Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val Tyr Ala 
945                 950                 955                 960 


Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile Lys Leu 
                965                 970                 975     


Glu Asp Leu Ser Asn Asp Ser Ser Ala 
            980                 985 


<210>  1967
<211>  1126
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1967

Met Glu Asp Asp Lys Lys Thr Thr Glu Ser Thr Asn Met Leu Asp Asn 
1               5                   10                  15      


Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val Tyr 
            20                  25                  30          


Ile Thr Val Asn His Ile Asn Lys Ile Leu Glu Glu Gly Glu Ile Asn 
        35                  40                  45              


Arg Asp Gly Tyr Glu Asn Thr Leu Glu Asn Ser Trp Asp Glu Ile Lys 
    50                  55                  60                  


Asp Ile Asn Lys Lys Asp Arg Leu Ser Lys Leu Ile Ile Lys His Phe 
65                  70                  75                  80  


Pro Phe Leu Glu Ala Thr Thr Tyr Arg Gln Asn Pro Thr Asp Thr Thr 
                85                  90                  95      


Lys Gln Lys Glu Glu Lys Gln Ala Glu Ala Gln Ser Leu Glu Asn Leu 
            100                 105                 110         


Lys Glu Ser Phe Phe Val Phe Ile Tyr Lys Leu Arg Asp Leu Arg Asn 
        115                 120                 125             


His Tyr Ser His Tyr Lys His Ser Lys Ser Leu Glu Arg Pro Lys Phe 
    130                 135                 140                 


Glu Glu Asp Leu Gln Lys Lys Met Tyr Asn Ile Phe Asn Ala Ser Ile 
145                 150                 155                 160 


Arg Leu Val Lys Glu Asp Tyr Gln Tyr Asn Lys Asn Ile Asn Pro Lys 
                165                 170                 175     


Lys Asp Phe Lys His Leu Asp Arg Lys Arg Lys Gly Lys Phe Tyr Tyr 
            180                 185                 190         


Ser Phe Ala Asp Asn Glu Gly Asn Ile Thr Glu Ser Gly Leu Leu Phe 
        195                 200                 205             


Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Met Gln Gln 
    210                 215                 220                 


Lys Leu Thr Gly Phe Lys Asp Asn Arg Glu Ser Lys Lys Lys Met Thr 
225                 230                 235                 240 


His Glu Val Phe Cys Arg Arg Arg Met Leu Leu Pro Lys Leu Arg Leu 
                245                 250                 255     


Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu Asn Glu 
            260                 265                 270         


Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Gln Gly Glu Tyr 
        275                 280                 285             


Arg Lys Lys Phe Asn Val Pro Phe Asp Pro Ala Asp Glu Asp Tyr Asp 
    290                 295                 300                 


Ala Glu Gln Glu Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg 
305                 310                 315                 320 


Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Tyr Asn Glu Ile Phe Thr 
                325                 330                 335     


Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile Tyr 
            340                 345                 350         


Lys Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg His Leu Thr His Lys 
        355                 360                 365             


Leu Tyr Gly Phe Glu Arg Ile Gln Glu Phe Ala Lys Gln Asn Arg Pro 
    370                 375                 380                 


Asp Glu Trp Lys Ala Ile Val Lys Asp Leu Asp Thr Tyr Glu Thr Ser 
385                 390                 395                 400 


Asn Glu Arg Tyr Ile Ser Glu Thr Thr Pro His Tyr His Leu Glu Asn 
                405                 410                 415     


Gln Lys Ile Gly Ile Arg Phe Arg Asn Gly Asn Asn Asp Ile Trp Pro 
            420                 425                 430         


Ser Leu Glu Thr Asn Gly Glu Lys Asn Glu Lys Ser Lys Tyr Lys Leu 
        435                 440                 445             


Asp Lys Gln Tyr Gln Ala Glu Ala Phe Leu Ser Val His Glu Leu Leu 
    450                 455                 460                 


Pro Met Met Phe Tyr Tyr Leu Leu Leu Lys Thr Glu Asn Thr Asp Asn 
465                 470                 475                 480 


Asp Asn Glu Ile Glu Thr Lys Lys Lys Glu Asn Lys Asn Asp Lys Gln 
                485                 490                 495     


Glu Lys His Lys Ile Glu Glu Ile Ile Glu Asn Lys Ile Lys Asp Ile 
            500                 505                 510         


Tyr Ala Leu Tyr Asp Ala Phe Ala Asn Gly Glu Ile Asn Ser Lys Glu 
        515                 520                 525             


Glu Leu Lys Glu Tyr Leu Lys Gly Lys Asp Ile Glu Ile Val His Leu 
    530                 535                 540                 


Pro Lys Gln Met Ile Ala Ile Leu Lys Asn Lys His Lys Asp Met Val 
545                 550                 555                 560 


Glu Lys Ala Glu Ala Lys Gln Glu Lys Met Lys Leu Ala Thr Glu Asn 
                565                 570                 575     


Arg Leu Lys Thr Leu Asp Lys Gln Leu Lys Gly Lys Ile Gln Asn Gly 
            580                 585                 590         


Lys Arg Tyr Asn Ser Ala Pro Lys Ser Gly Glu Ile Ala Ser Trp Leu 
        595                 600                 605             


Val Asn Asp Met Met Arg Phe Gln Pro Val Gln Arg Asp Glu Asn Gly 
    610                 615                 620                 


Glu Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln Leu Leu 
625                 630                 635                 640 


Gln Arg Thr Leu Ala Phe Phe Gly Ser Glu His Glu Arg Leu Ala Pro 
                645                 650                 655     


Tyr Phe Lys Gln Thr Lys Leu Ile Glu Ser Ser Thr Pro His Pro Phe 
            660                 665                 670         


Leu Asn Glu Thr Glu Trp Glu Lys Cys Asn Asn Ile Leu Ser Phe Tyr 
        675                 680                 685             


Arg Ser Tyr Leu Lys Ala Arg Lys Asn Phe Leu Glu Ser Leu Lys Pro 
    690                 695                 700                 


Glu Asp Trp Glu Lys Asn Gln Tyr Phe Leu Met Leu Lys Glu Pro Lys 
705                 710                 715                 720 


Thr Asn Arg Lys Thr Leu Val Gln Gly Trp Lys Asn Gly Phe Asn Leu 
                725                 730                 735     


Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg Lys Trp Phe Met Glu His 
            740                 745                 750         


Trp Lys Asn Ile Lys Val Asp Asp Ser Lys Arg Val Gly Leu Val Ala 
        755                 760                 765             


Lys Val Ile Pro Leu Phe Phe Ser Glu Lys Tyr Lys Asp Ser Val Gln 
    770                 775                 780                 


Pro Phe Tyr Asn Tyr Pro Phe Asn Val Gly Asp Val Asn Lys Pro Lys 
785                 790                 795                 800 


Glu Glu Asp Phe Leu His Arg Glu Glu Arg Ile Glu Leu Trp Asp Lys 
                805                 810                 815     


Lys Lys Asp Lys Phe Lys Gly Tyr Lys Ala Lys Lys Lys Phe Lys Glu 
            820                 825                 830         


Met Thr Asp Lys Glu Lys Glu Glu His Arg Ser Tyr Leu Glu Phe Gln 
        835                 840                 845             


Ser Trp Asn Lys Phe Glu Arg Glu Leu Arg Leu Val Arg Asn Gln Asp 
    850                 855                 860                 


Ile Val Thr Trp Leu Leu Cys Thr Glu Leu Ile Asp Lys Leu Lys Ile 
865                 870                 875                 880 


Asp Glu Leu Asn Ile Lys Glu Leu Lys Lys Leu Arg Leu Lys Asp Ile 
                885                 890                 895     


Asn Thr Asp Thr Ala Lys Glu Glu Lys Asn Asn Ile Leu Asn Arg Val 
            900                 905                 910         


Met Pro Met Glu Leu Pro Val Thr Val Tyr Glu Val Asn Lys Gly Gly 
        915                 920                 925             


Tyr Ile Ile Lys Asn Lys Pro Leu His Thr Ile Tyr Ile Lys Glu Ala 
    930                 935                 940                 


Lys Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys Asp 
945                 950                 955                 960 


Arg Arg Leu Asn Gly Leu Phe Ser Phe Val Lys Thr Pro Ser Glu Ala 
                965                 970                 975     


Glu Ser Glu Ser Asn Pro Ile Ser Lys Ser Arg Val Glu Ser Glu Leu 
            980                 985                 990         


Gly Lys Tyr Gln Asn Ala Arg Leu  Asn Ile Ile Glu Asp  Met Leu Ala 
        995                 1000                 1005             


Leu Glu  Lys Thr Leu Ile Asp  Asn Tyr Asn Ser Leu  Asp Thr Asp 
    1010                 1015                 1020             


Asn Phe  Ser Leu Asp Thr Asp  Asn Phe His Asn Met  Leu Thr Gly 
    1025                 1030                 1035             


Trp Leu  Lys Leu Lys Ser Lys  Ala Asn Lys Ala Arg  Phe Gln Asn 
    1040                 1045                 1050             


Glu Val  Asp Leu Leu Val Ala  Val Arg Asn Ala Phe  Ser His Asn 
    1055                 1060                 1065             


Gln Tyr  Pro Met Tyr Asn Glu  Asn Leu Phe Gly Asn  Ile Glu Arg 
    1070                 1075                 1080             


Phe Ser  Leu Ser Ser Ser Asn  Ile Ile Glu Ser Lys  Gly Phe Asp 
    1085                 1090                 1095             


Ile Ala  Val Lys Leu Lys Glu  Glu Val Ser Lys Ala  Val Glu Lys 
    1100                 1105                 1110             


Ile Gln  Asn Glu Glu Asp Asn  Lys Lys Glu Lys Glu  Thr 
    1115                 1120                 1125     


<210>  1968
<211>  985
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1968

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Asn Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys Gly Tyr 
                165                 170                 175     


Ala Phe Phe Ile Ser Lys Phe Leu Glu Arg Lys Tyr Ser Tyr Leu Phe 
            180                 185                 190         


Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln Tyr Arg 
        195                 200                 205             


Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro Val Glu 
    210                 215                 220                 


Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu Asp Ile 
225                 230                 235                 240 


Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr Leu Glu 
                245                 250                 255     


Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr Asp Ala 
            260                 265                 270         


Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe Arg Ser 
        275                 280                 285             


Arg Phe Glu Ala Phe Thr Leu His Phe Leu Asp Lys Gln Ala Asp Phe 
    290                 295                 300                 


Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His Asn Gly 
305                 310                 315                 320 


Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr Ile Asn 
                325                 330                 335     


Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser Ala Lys 
            340                 345                 350         


Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser Thr Asp 
        355                 360                 365             


Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln Ser Thr 
    370                 375                 380                 


Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val Leu Pro 
385                 390                 395                 400 


Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala Lys Met 
                405                 410                 415     


Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala Met Leu 
            420                 425                 430         


Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His Cys Pro 
        435                 440                 445             


Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser Thr Lys 
    450                 455                 460                 


Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg Val Met 
465                 470                 475                 480 


Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu Arg Ile 
                485                 490                 495     


Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile Leu Lys 
            500                 505                 510         


Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp Leu Gln 
        515                 520                 525             


Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn Phe Gln 
    530                 535                 540                 


Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn Asp Leu 
545                 550                 555                 560 


Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn Pro His 
                565                 570                 575     


Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile Glu Phe 
            580                 585                 590         


Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg Ile Gln 
        595                 600                 605             


Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro Leu Arg 
    610                 615                 620                 


Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu Ala Ile 
625                 630                 635                 640 


Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys Leu Lys 
                645                 650                 655     


Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu Lys Ser 
            660                 665                 670         


Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg Ala Tyr 
        675                 680                 685             


Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn Tyr Arg 
    690                 695                 700                 


Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser Tyr Leu 
705                 710                 715                 720 


Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro Ser Lys 
                725                 730                 735     


Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp Arg Leu 
            740                 745                 750         


Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile Ile Arg 
        755                 760                 765             


Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys Glu Tyr 
    770                 775                 780                 


Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu Glu Asn 
785                 790                 795                 800 


Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp Leu Asn 
                805                 810                 815     


Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr Gly Lys 
            820                 825                 830         


Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn Lys Val 
        835                 840                 845             


Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val Lys Ile 
    850                 855                 860                 


Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu Glu Ala 
865                 870                 875                 880 


Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala Met Val 
                885                 890                 895     


Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr Tyr Asp 
            900                 905                 910         


Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln Lys Ile 
        915                 920                 925             


Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His Asp Lys 
    930                 935                 940                 


Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val Tyr Ala 
945                 950                 955                 960 


Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile Lys Leu 
                965                 970                 975     


Glu Asp Phe Ser Asn Asp Ser Ser Ala 
            980                 985 


<210>  1969
<211>  1174
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1969

Met Asn Pro Glu Asn Asn Ile Val Lys Asn Tyr Ser Val Lys Glu Thr 
1               5                   10                  15      


Pro Trp Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg His Asn Val Tyr 
            20                  25                  30          


Leu Leu Ile Asn His Leu Thr Asp Lys Phe Ser Tyr Leu Lys Asn Tyr 
        35                  40                  45              


Lys Lys Leu Ser Leu Glu Lys Gln Thr Gly Thr Ser Lys Phe Glu Leu 
    50                  55                  60                  


Arg Pro Gln Pro Phe Ser Ile Leu Thr Asp Asp Glu Gln Ile Val Asn 
65                  70                  75                  80  


Glu Asn Ile Leu Thr Lys Ile Phe Asp Thr Ser Tyr Pro Gln Tyr Asp 
                85                  90                  95      


Asn Asp Arg Phe Arg Ile Tyr Lys Tyr Met Val Arg Lys His Ser Leu 
            100                 105                 110         


Pro Phe Ile Lys Asn Phe Ser Glu Thr Gly Gly Arg Asn Leu Asp Asp 
        115                 120                 125             


Asn Pro Ile Ile Asp Tyr Asp Gly Leu His Gln Tyr Ile Asn Glu Ala 
    130                 135                 140                 


Phe Ala Leu Leu Val Arg Leu Arg Asp Ser Phe Ser His Tyr Leu Ala 
145                 150                 155                 160 


Ile Asp Lys Phe Gly Asn Lys Ile Glu Asp Arg Asn Leu Thr Val Ser 
                165                 170                 175     


Thr Asn Ile His Thr Gln Val Ile Asn Leu Tyr Thr Asn Ser Pro Asn 
            180                 185                 190         


Tyr Ser Leu Glu Arg Phe Ser Ala Thr Gln Ser Asp Phe Asp Tyr Glu 
        195                 200                 205             


His Leu Ser Leu Tyr Lys Ile Phe Glu Ala Asp Asn Ile Thr Phe Thr 
    210                 215                 220                 


Glu Gln Gly Leu Tyr Phe Phe Ile Asn Leu Phe Leu Glu Arg Gly Tyr 
225                 230                 235                 240 


Gly Ile Lys Phe Leu Lys Lys Ile Arg Gly Phe Lys Asn Asp Thr Asn 
                245                 250                 255     


Pro Ala Phe Arg Ala Thr Ile Lys Thr Phe Thr Thr Tyr Ala Leu Lys 
            260                 265                 270         


Val Pro Asp Glu Arg Leu Asp Asn Asp Asp Pro Arg Met Ser Leu Leu 
        275                 280                 285             


Met Asp Val Leu Asn Glu Leu Lys Arg Cys Pro Ala Ile Leu Ser Lys 
    290                 295                 300                 


His Leu Ser Asp Gln Asp Gln Lys Lys Phe Asn Pro Gln Leu Asn Asp 
305                 310                 315                 320 


Asp Ser Lys Ala Asn Val Leu Leu Asn Ser Val Asn Tyr Asp Asp Ile 
                325                 330                 335     


Asp Asp Glu Gln Ile Asp Tyr Leu Leu Asn Ser Ile Thr Thr Phe Lys 
            340                 345                 350         


Arg His Gln Asp Arg Phe Pro Tyr Phe Ala Leu Arg Cys Ile Asp Glu 
        355                 360                 365             


Leu Asn Leu Leu Pro Asn Ile Arg Phe Gln Val Ala Leu Gly Ser Ile 
    370                 375                 380                 


Glu Arg Arg Ser Tyr Asp Lys Val Val Gly Asp Val Ile Ile Asp Arg 
385                 390                 395                 400 


Arg Ile Leu Lys Lys Leu Asn Ala Phe Gly Lys Leu Ser Tyr Phe Glu 
                405                 410                 415     


Gly Lys Glu Glu Gln Val Leu Leu Glu Leu Asn Arg Lys Val Lys Asp 
            420                 425                 430         


Gln Asp Leu Leu Phe Asp Gln Phe Asn Pro His Tyr Asn Ile Asn Asn 
        435                 440                 445             


Asn Lys Ile Gly Phe Tyr Thr Phe Ser Ser Gly Lys Glu Lys Ile Gln 
    450                 455                 460                 


Trp Pro Thr Ile Ala Asp Phe Pro Lys Glu Gly Asn Leu His Gln Lys 
465                 470                 475                 480 


Arg Asp Asn Ser Ile Pro Lys Ser Phe Leu Ser Ile His Glu Leu Pro 
                485                 490                 495     


Lys Leu Leu Leu Leu Ala Leu Lys Asp Pro Glu Leu Ala Glu Lys Thr 
            500                 505                 510         


Ile Thr Asp Phe Leu Asp Val Asn Lys Asn Leu Val Leu Asn Lys Ala 
        515                 520                 525             


Ala Leu Gly Gln Ile Arg Asp Lys Ile Lys Leu Cys Pro Ser Ile Phe 
    530                 535                 540                 


Asn Arg Arg Arg Val Glu Glu Lys Ala Leu Lys Gln Lys Gly Arg Ile 
545                 550                 555                 560 


Gln Phe Leu Asn His Ala Gln Ile Lys Asn Leu Arg Gln Arg Asn Lys 
                565                 570                 575     


Ile Thr Asp Glu Arg Leu Ala Asp Leu Lys Phe Met Asp Ser Met Ile 
            580                 585                 590         


Ser Asn Thr Lys Asn Ile Lys Ile Lys Glu Tyr Leu Lys Gln Ile Asn 
        595                 600                 605             


Tyr Asn Gln Val Leu Glu Thr Arg Lys Asp Ala Leu Arg Gln Val Leu 
    610                 615                 620                 


Pro Ala Gly Leu Lys Val Asn Gln Leu Pro Thr Ile Val Ile Asp Tyr 
625                 630                 635                 640 


Leu Leu Gly Met Val Gly Gln Asp Pro His Lys Lys Ile Leu Ala Arg 
                645                 650                 655     


Phe Lys Glu Ile Lys Thr Asp Thr Asn Lys Arg Leu Lys Gln Leu Asp 
            660                 665                 670         


Arg Asp Asp Asp Ser Arg Leu Lys Val Gly Glu Ile Ala Thr Phe Leu 
        675                 680                 685             


Thr Lys Asp Ile Ile Asn Leu Val Ile Ser Glu Asp Leu Lys Lys Lys 
    690                 695                 700                 


Ile Thr Ser Ala Tyr Tyr Gly Arg Ile Gln Tyr Gln Phe Ala Asn Phe 
705                 710                 715                 720 


Ser Ile Ser Lys Gly Glu Leu Thr Thr Ile Ile Glu Gln Leu Gly Leu 
                725                 730                 735     


Phe Asp Asn Ile Lys Gly His Pro Phe Leu Ala Ser Ser Met Leu Asn 
            740                 745                 750         


Lys Val Lys Gly Ile Arg Glu Phe Tyr Asp Asn Tyr Leu Ser Ala Lys 
        755                 760                 765             


Leu Lys Trp Ile Asn Gly Ile Ile Ala Asn Lys Asn Leu Lys Asp Leu 
    770                 775                 780                 


Leu Lys Asn Asn Lys Ile Ser Leu Pro Phe Lys Ile Lys Ser Ile Ile 
785                 790                 795                 800 


Ser Lys Ser Glu Ala Lys Asn Leu Asp Asn Trp Leu Lys Ser Lys Lys 
                805                 810                 815     


Asp Met Pro Val Asp Leu Pro Val Ser Ile Phe Asp Asp Gln Leu Asn 
            820                 825                 830         


Thr Tyr Leu Lys Lys Glu Leu Gln His Val Asn Ile Ala Phe Gln Glu 
        835                 840                 845             


Thr Asp Lys Phe Ser Val Leu Leu Thr Lys Leu Leu Asn Gly Asp Lys 
    850                 855                 860                 


Gln Pro Phe Tyr Asn His Thr Arg Trp Tyr Arg Ser Glu Glu Gly Asp 
865                 870                 875                 880 


Val Pro Phe Ser Pro Asp Gly His Ser Ser Leu Thr Ile Lys Asn Asn 
                885                 890                 895     


Tyr Ser Ser Tyr Ala Glu Leu Thr Glu Lys Lys Ile Arg His Val Gln 
            900                 905                 910         


Thr Gln Asp Arg Val Leu Arg Leu Ala Cys Gln Ser Ile Leu Gly Gln 
        915                 920                 925             


Leu Ser Asp Val Asp Asp Thr Leu Thr Phe Tyr Leu Gln Asp Ile Leu 
    930                 935                 940                 


Ala Phe Thr Asn Thr Asn Pro Leu Asn Arg Pro Ala Thr Phe Lys His 
945                 950                 955                 960 


Lys Leu Lys Glu Ile Ser Ser Glu Gly Val Tyr Val Val Ala Glu Asp 
                965                 970                 975     


Thr Leu Ser Gln Lys Glu Glu Val Val Lys Tyr Leu Val Leu Glu Gln 
            980                 985                 990         


Glu Glu Glu Gln Asn Leu Tyr Asp  Gly Gln Lys Gly Phe  Gln Trp Thr 
        995                 1000                 1005             


Ile Lys  Asp Phe Gly Arg Phe  Arg Arg Phe Met His  Asp Arg Arg 
    1010                 1015                 1020             


Leu Pro  Ala Ile Phe Asn Tyr  Leu Glu Thr Ser Ile  Ser Ser Tyr 
    1025                 1030                 1035             


Asp Leu  Leu Ser Tyr Gln Ile  Ser Glu Tyr Asp Arg  Tyr Arg Glu 
    1040                 1045                 1050             


Ala Ile  Phe Arg Glu Thr Phe  Glu Leu Glu Ala Tyr  Leu Ala Asn 
    1055                 1060                 1065             


Thr Tyr  Phe Asp Glu Val Val  Val Leu Lys Leu Gln  Asp Lys Ala 
    1070                 1075                 1080             


Ile Phe  Pro Gln Val Gln Phe  Lys Thr Tyr Leu Glu  Leu Ile Lys 
    1085                 1090                 1095             


Gln Arg  Asn Met Leu Asp Lys  Ala Ala Cys Glu Phe  Ile Asn Ser 
    1100                 1105                 1110             


Ile Arg  Asn Lys Phe Ser His  Ser Glu Phe Pro Asp  Tyr Tyr Pro 
    1115                 1120                 1125             


Glu Ile  Ser Lys Ile Thr Val  Asp Asp Ile Asp Asp  Phe Glu Leu 
    1130                 1135                 1140             


Asn Lys  Ser Lys Lys Gly Phe  Lys Glu Tyr Ala Gly  Leu Ser Ile 
    1145                 1150                 1155             


Ser Lys  Lys Val Phe Asp Leu  Tyr Gln Ser Ile Met  Val Ser Cys 
    1160                 1165                 1170             


Lys 
    


<210>  1970
<211>  1138
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1970

Met Glu Thr Leu Tyr Asn Ser Thr Asn Glu Asn Ser Arg Arg Asn Leu 
1               5                   10                  15      


Asn Asp Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Leu Ala Arg Leu 
            20                  25                  30          


Asn Ile Phe Ser Ile Asn Asn His Leu Ala Glu Glu Phe Lys Gln Lys 
        35                  40                  45              


Asn Arg Leu Thr Asp Glu Glu His Ile Arg Asn Ser Phe Ile Cys Asn 
    50                  55                  60                  


Ser Asn Ile Lys Asn Leu Asn Tyr Asn Trp Leu Phe Glu Lys Leu Ile 
65                  70                  75                  80  


Arg Leu Met Pro Ile Val Lys Gln Phe Asp Ser Ser Arg Leu Pro Glu 
                85                  90                  95      


Glu Glu Gln Lys Lys Gly Asp Thr Glu Gly Lys Asn Leu Leu Leu Met 
            100                 105                 110         


Ala Glu Thr Leu Lys Glu Val Phe Lys Asp Ile Gln Asp Phe Arg Asn 
        115                 120                 125             


Asp Tyr Thr His Tyr Tyr Ser Val Glu Lys Gly Asp Glu Arg Lys Leu 
    130                 135                 140                 


Asn Val Ser Ser Ala Thr Ala Asp Phe Leu Val Thr Ser Phe His Arg 
145                 150                 155                 160 


Ala Ile Glu Tyr Thr Lys Ser Arg Phe Ala Asn Val Phe Ser Glu Asp 
                165                 170                 175     


Asp Phe Lys Leu Ile Gln Ala Lys Gln Leu Val Leu Ser Asn Asn Ser 
            180                 185                 190         


Ile Thr Val Glu Gly Leu Val Phe Leu Thr Ala Met Phe Leu Asp Arg 
        195                 200                 205             


Glu Asn Ala Phe Gln Phe Ile Gly Lys Val Gln Gly Leu Lys Gly Thr 
    210                 215                 220                 


Gln Phe Lys Ser Phe Ile Ala Ser Arg Glu Val Leu Met Ala Tyr Cys 
225                 230                 235                 240 


Val Arg Leu Pro His Asp Lys Leu Ile Ser Asp Asp Pro Lys Gln Ala 
                245                 250                 255     


Leu Leu Leu Asp Met Leu Asn Glu Leu Asp Arg Cys Pro Lys Leu Leu 
            260                 265                 270         


Tyr Asn Val Leu Ser Glu Asp Ala Lys Lys Gln Phe Arg Pro Ile Leu 
        275                 280                 285             


Thr Lys Gln Ser Ile Glu Gln Val Leu Glu Asn Ser Val Ser Asp Glu 
    290                 295                 300                 


Glu Arg Glu Asn Ile Leu Asp Asn Ile Asp Tyr Ser Glu Tyr Ile Glu 
305                 310                 315                 320 


Gln Leu Thr Val Arg Val Arg His Ser Asn Arg Phe His Tyr Phe Ala 
                325                 330                 335     


Met Arg Phe Ile Asp Glu Gln Asn Leu Leu Pro Asp Phe Phe Phe Gln 
            340                 345                 350         


Ile Asp Leu Gly Lys Tyr Lys Leu Ser Glu Tyr Glu Lys Ser Ile Leu 
        355                 360                 365             


Gly Gln Ser Ile Pro Arg Ser Ile Ile Glu Asn Ala Lys Ala Phe Gly 
    370                 375                 380                 


Arg Leu Ser Lys Phe Val Ser Glu Asp Asp Val Gln Lys Ile Ile Asp 
385                 390                 395                 400 


Pro Gly Asn Leu Ala Asn Gly Phe Glu Gln Phe Ala Pro His Tyr Asn 
                405                 410                 415     


Thr Asp Ile Asn Lys Ile Gly Phe Arg Phe Asn Glu Asp Ile Cys His 
            420                 425                 430         


Ile Glu Ser Ile Asp Ala Lys Ala Glu Arg Arg Ile Ser Val Asn Leu 
        435                 440                 445             


Ile Gln Pro Gln Pro Met Gly Phe Leu Ser Leu His Glu Leu Ser Lys 
    450                 455                 460                 


Ile Ile Leu Leu Glu Tyr Leu Gln Pro Gly Glu Ser Ile Lys Leu Ile 
465                 470                 475                 480 


Arg Gln Phe Tyr Lys Thr Ala Asn Thr Gln Leu Phe Asn Ile Asp Phe 
                485                 490                 495     


Ile Glu Leu Val Lys Thr Lys Leu Pro Thr Asn Trp Gly Asp Leu Glu 
            500                 505                 510         


Lys Gln Cys Asp Thr Lys Asn Asn Lys Ala Tyr Arg Asn Ser Lys Ala 
        515                 520                 525             


Ser Leu Tyr Glu Leu Gln Lys Arg Lys Glu Glu Leu Asp Lys Val Leu 
    530                 535                 540                 


Gln Phe His Gly Leu Asn Trp Thr Gln Ile Pro Glu Arg Ile Leu Asn 
545                 550                 555                 560 


Tyr Trp Leu Asn Ile Gln Asp Val Ser Tyr Ser Lys Ser Ile Ser Glu 
                565                 570                 575     


Arg Ile Leu Leu Met Lys Arg Asp Gly Leu Lys Arg Leu Lys Gln Leu 
            580                 585                 590         


Lys Asn His Ser Asn Arg Pro Asp Val Arg Ile Pro Lys Val Gly Glu 
        595                 600                 605             


Met Ala Thr Phe Ile Ala Arg Asp Ile Val Asp Met Ile Ile Asp Glu 
    610                 615                 620                 


Glu Lys Lys Lys Lys Ile Thr Ser Ile Tyr Tyr Asp Lys Leu Gln Glu 
625                 630                 635                 640 


Cys Leu Ala Phe Tyr Ala Asp Lys Glu Lys Lys Gln Gln Leu Ile Gly 
                645                 650                 655     


Leu Val Arg Glu Leu Gln Leu Asn Leu Gln Gly Gly His Pro Phe Leu 
            660                 665                 670         


Lys Asn Leu Arg Leu Glu Ser Ile Arg Lys Thr Ser Glu Phe Tyr Glu 
        675                 680                 685             


Leu Tyr Leu Thr Glu Lys Phe Ser Lys Leu Val His Lys Gly Leu Asn 
    690                 695                 700                 


Gln Lys Gly Lys Pro Gln Ser Arg Asp Glu Ser Trp Ile Ile Arg Thr 
705                 710                 715                 720 


Phe Glu Lys Lys Glu Trp Ser Asp Lys Ala Lys Lys Asn Leu Thr Val 
                725                 730                 735     


Tyr Lys Phe Pro Asp Asn Met Lys Glu Leu Pro Phe Ser Met Gln Gln 
            740                 745                 750         


Trp Ile Asn Lys Glu Gln Tyr Asp Leu Arg Gly Trp Leu Arg Asn Ile 
        755                 760                 765             


Asn Glu Gly Arg Asn Arg Asn Asp Gln Lys Arg Pro Ile Asp Leu Pro 
    770                 775                 780                 


Thr Asn Leu Phe Asn Asn Lys Leu Cys Glu Leu Leu Thr Gln Glu Leu 
785                 790                 795                 800 


Arg Leu Ala Gly Lys Ala Ile Pro Asn Thr Thr Lys Tyr Tyr Glu Leu 
                805                 810                 815     


Leu Arg Val Trp Trp Leu Asn Arg Asp Asp Ser Val Gln Gly Phe Tyr 
            820                 825                 830         


Lys Gly Ser Arg Ser Tyr Ile Ile Lys Asp Glu Leu Val Ser Phe Ile 
        835                 840                 845             


Pro Asp Ser Gln Pro Asn Phe Lys Lys Tyr Tyr Gln Glu Pro Leu Asn 
    850                 855                 860                 


Lys Ala Phe Ile Arg Leu Ser Gln Lys Arg Gln Met Asp Arg Glu Lys 
865                 870                 875                 880 


Asp Lys Lys Leu Pro Val Leu Asp Lys Thr Asp Ile Glu Lys Thr Phe 
                885                 890                 895     


Lys Lys Thr Leu Phe Asp Thr Glu Lys Asn Ile Arg Leu Leu Ala Glu 
            900                 905                 910         


Asp Asp Arg Ile Leu Leu Leu Met Ala Glu Lys Leu Ser Pro Gly Asp 
        915                 920                 925             


Gly Ser Gly His Leu Lys Leu Asn Asn Ile Lys Lys Glu Leu Asn Lys 
    930                 935                 940                 


Glu Gln Ile Lys Glu Arg Ala Phe Gln Phe Arg Pro Asn Tyr Asp Asp 
945                 950                 955                 960 


Ala Gly Asn Met Pro Glu Lys Gly Val Leu Leu Pro Glu Ile Gln Leu 
                965                 970                 975     


Ile Val Glu Ala Lys Ile Arg Leu Lys Asn Ile Lys Asp Leu Asn Arg 
            980                 985                 990         


Phe Ala Tyr Asp Arg Arg Leu Pro  Glu Leu Ile Ala Tyr  Leu Pro Asn 
        995                 1000                 1005             


Gly Lys  Ile Gly Val Asn Glu  Leu Arg Tyr Glu Leu  Thr Asp Tyr 
    1010                 1015                 1020             


Asn Lys  Ala Arg Gln Glu Val  Phe Asp Glu Val Phe  Arg Leu Glu 
    1025                 1030                 1035             


Lys Thr  Ile Ile Gln Lys Asp  Ala Asp Gly Leu Leu  Ala Leu Cys 
    1040                 1045                 1050             


Val Asn  Glu Arg Gly Ile Pro  Leu Arg Gly Asn Ile  Ala His Lys 
    1055                 1060                 1065             


Tyr Phe  Leu Gln Trp Leu Ile  Asn His Gly Tyr Ile  Ser Glu Gln 
    1070                 1075                 1080             


Glu Arg  Lys Tyr Leu Asn Met  Ile Arg Asn Ser Phe  Ser His Asn 
    1085                 1090                 1095             


Gln Phe  Pro His Lys Leu Ile  Val Ser Tyr Ser Gln  Asn Gln Ile 
    1100                 1105                 1110             


Asn Gln  Lys Gly Ile Ala Ser  Ile Ile Ser Ser Ala  Phe Lys Glu 
    1115                 1120                 1125             


Lys Thr  Glu Ser Ile Ile Tyr  Lys Ile Asp 
    1130                 1135             


<210>  1971
<211>  1125
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1971

Met Lys Lys Thr Asn Ala Glu Glu Ser Asn Phe Asn His Thr Leu Asn 
1               5                   10                  15      


Asp Gln Lys Tyr Tyr Phe Ala Gly Tyr Leu Asn Leu Ala Glu Asn Asn 
            20                  25                  30          


Ile Lys Thr Leu Glu Lys Ala Tyr Gly Glu His Phe Leu Cys Ser Gly 
        35                  40                  45              


Lys Glu Thr Ile Ile Ser Asn Leu Asn Asn Thr Ser Ser Leu Ile Asp 
    50                  55                  60                  


Trp Asp Leu Lys Val Lys Phe Leu Ser Gln Tyr Leu Pro Val Val Ser 
65                  70                  75                  80  


Tyr Leu Asn Leu Asp Thr Asp Pro Asn Ser Thr Phe Lys Ile Ile Lys 
                85                  90                  95      


Lys Glu Phe Ser Glu Asn Leu Ser Ser Leu Phe Asp Ser Ile Gly Ser 
            100                 105                 110         


Leu Arg Asn Phe Tyr Ser His Tyr Tyr His Arg Pro Leu Thr Glu Glu 
        115                 120                 125             


Leu Asn Ile Glu Leu Leu Ser Phe Leu Asp Arg Thr Phe Val Ala Val 
    130                 135                 140                 


Cys Ile Asn Val Lys Lys Lys Arg Met Lys Asp Asp Lys Thr Lys Gln 
145                 150                 155                 160 


Leu Leu Lys Ala Thr Leu Asn Asn Glu Leu Asp Leu Leu Leu Lys Ala 
                165                 170                 175     


Lys Lys Glu Glu Leu Leu Lys Lys Lys Lys Glu Gly Lys Lys Val Ser 
            180                 185                 190         


Ile Asp Ala Ile Ser Met Lys Asn Ser Val Leu Asn Asp Ala Phe Asn 
        195                 200                 205             


His Leu Val Gln Leu Asp Lys Asn Ser Arg Glu Glu Ile Pro Gly Arg 
    210                 215                 220                 


Phe Tyr Thr Ser Val Leu Gly Asp Asn Asn Lys Tyr Thr Glu Asn Glu 
225                 230                 235                 240 


Ile Asn Ile Ser Met Ser Gly Leu Leu Phe Leu Leu Ser Met Phe Leu 
                245                 250                 255     


Thr Lys Lys Gln Asn Glu Asp Met Arg Ser Arg Ile Phe Gly Phe Lys 
            260                 265                 270         


Gly Thr Ile Asp Pro Asp Lys Ser Ile Ser Lys Ser Asn Asn Ser Phe 
        275                 280                 285             


Arg Asn Met Ala Thr Asn Trp Val Phe Ser Tyr Leu Ser Phe Lys Gly 
    290                 295                 300                 


Met Lys Lys Gln Leu Gly Asn Thr Phe Lys Lys Glu Ser Leu Leu Val 
305                 310                 315                 320 


Gln Ile Val Asp Glu Leu Ser Lys Val Pro His Glu Val Tyr Gln Thr 
                325                 330                 335     


Leu Ser Pro His His Gln Glu Met Phe Leu Glu Asp Met Asn Glu Tyr 
            340                 345                 350         


Leu Lys Glu Gly Asn Lys Lys Leu Cys Leu Glu Asp Ser Ile Val Val 
        355                 360                 365             


His Pro Val Ile Arg Lys Arg Tyr Glu Asp Lys Phe Asn Tyr Phe Ala 
    370                 375                 380                 


Ile Arg Tyr Leu Asp Glu Phe Val Glu Phe Pro Ser Leu Arg Phe Gln 
385                 390                 395                 400 


Val Asn Val Gly Asn Tyr Val His Asp Arg Arg Met Lys Thr Ile Asp 
                405                 410                 415     


Gly Thr Lys Thr Glu Thr Asp Arg Met Val Lys Glu Glu Ile Arg Ala 
            420                 425                 430         


Phe Gly Lys Leu Ser Val Ile Ser Lys Leu Lys Ala Asp Phe Phe Ala 
        435                 440                 445             


Lys Asp Leu Pro Ser Asp Ile Ser Trp Glu Met Tyr Pro Asn Pro Ser 
    450                 455                 460                 


Tyr Asn Ile Ser Ala Asn Asn Ile Pro Val Tyr Ile Asp Leu Ile Lys 
465                 470                 475                 480 


Ser Ser Val Ala Gly Ala Val Asp Val Gly Lys Asp His Lys Ser Tyr 
                485                 490                 495     


Gln Ala Lys Leu Asp Leu Asp Glu Asp Lys Arg Lys Arg Asn Arg Lys 
            500                 505                 510         


Glu Gly Lys Pro Gly Lys Thr Glu Ile Ala Arg Ile Leu Leu Gly Lys 
        515                 520                 525             


Lys Gln Ile Leu Phe Glu Lys Pro Thr Val Leu Leu Ser Leu Asn Glu 
    530                 535                 540                 


Leu Pro Ala Leu Leu Tyr Glu Val Leu Lys Glu Gly Gly Asp Lys Gln 
545                 550                 555                 560 


Asp Ile Gly Lys Arg Ile Glu Asp Lys Ile Val Glu Lys Ile Val Ala 
                565                 570                 575     


Gln Tyr Lys Leu Ile Asp Gln Tyr Asp Gly Thr Ile Glu Leu Pro Gly 
            580                 585                 590         


Ser Val Ile Pro Lys Lys Leu Arg Lys Ser Gly Ser Glu Lys Cys Thr 
        595                 600                 605             


Asn Met Asp Lys Leu Leu Arg Ala Val Lys Arg Glu Leu Glu Ile Thr 
    610                 615                 620                 


Gln Glu Lys Leu Asp Leu Ile Lys Asn Asn Lys Lys Lys Phe Glu Ser 
625                 630                 635                 640 


Lys Glu Lys Asp Glu Lys Gly Lys Ala Arg Gln His Val Phe Tyr Thr 
                645                 650                 655     


Asn Glu Leu Gly Gln Glu Ala Thr Trp Ile Ala Asn Asp Ile Lys Arg 
            660                 665                 670         


Phe Met Pro Arg Asp Val Lys Glu Lys Trp Arg Gly Tyr His His Ser 
        675                 680                 685             


Asn Leu Gln Lys Leu Leu Ser Gln Tyr Asn Gln Ser Arg Asn Glu Ala 
    690                 695                 700                 


Val Lys Cys Ile Thr Cys Phe Trp Asn Phe Asp Gln Gln Thr Pro Trp 
705                 710                 715                 720 


Gly Lys Gly Ile Lys Glu Ala Phe Tyr Lys Ser Thr Phe Glu Glu Phe 
                725                 730                 735     


Tyr Lys Ala Tyr Leu Asp Asn Arg Met Asp Val Tyr Lys Thr Leu Glu 
            740                 745                 750         


Asn Asn Leu Ile Ala Ala Lys Gly His Ser Lys Leu Phe Asn Lys Glu 
        755                 760                 765             


Lys Lys Lys Ala Phe Val Leu Phe Asp Lys His Leu Tyr Asn Ile Pro 
    770                 775                 780                 


Asp Ile Asn Thr Gln Lys Glu Arg Leu Lys Ser Thr Leu Phe Ile Leu 
785                 790                 795                 800 


Pro Arg Gly Ile Phe Asp Ser Lys Pro Thr Phe Ile Lys Gly Ile Lys 
                805                 810                 815     


Tyr Glu Glu Asp Pro Ser Cys Phe Ala Asp Trp Tyr Gln Phe Ala Asn 
            820                 825                 830         


Asn Ala Gly Asn Glu Tyr Gln Gln Phe Tyr Asn Leu Thr Arg Ser Tyr 
        835                 840                 845             


Thr Ser Leu Phe Glu Glu Thr Lys Lys Asn Asn Glu Gly Leu Lys Glu 
    850                 855                 860                 


Asn Lys Lys Gly Leu Ser Ala Asp Glu Gln Phe Asp Phe Phe Lys Met 
865                 870                 875                 880 


Arg Gln Asp Leu Lys Ile Lys Lys Ile Lys Thr Gln Asp Leu Phe Leu 
                885                 890                 895     


Phe Gln Ile Val Lys Asp Leu Tyr Lys Lys Val Phe Gly Arg Thr Phe 
            900                 905                 910         


Pro Glu Gly Leu Glu Leu Lys Asp Met Tyr Gln Thr Pro Ala Glu Arg 
        915                 920                 925             


Gln Ala Asn Tyr Glu Leu Ala Val Lys Gln Ser Gln Arg Thr Glu Gly 
    930                 935                 940                 


Asp Lys Ser Asp Asn Leu Tyr Asn Thr Asn Phe Leu Trp Asn Leu Thr 
945                 950                 955                 960 


Val Pro Phe Glu Thr Gly Lys Ile Lys Glu Pro Gln Val Lys Leu Lys 
                965                 970                 975     


Asp Ile Gly Lys Phe Tyr Lys Phe Ala Ala Asp Glu Lys Val Gln Thr 
            980                 985                 990         


Ile Leu Ser Tyr Ser Asp Arg Glu  Trp Ser Lys Leu Asp  Leu Glu Lys 
        995                 1000                 1005             


Glu Leu  Glu Leu Met Pro Thr  Ser Tyr Glu Val Ile  Arg Arg Glu 
    1010                 1015                 1020             


Gln Leu  Leu Arg Asp Ile Gln  Gln Phe Glu Lys Arg  Ile Leu Glu 
    1025                 1030                 1035             


Asn Tyr  Pro Ser Asp Gly Asn  Ala His Pro Arg Asp  Phe Glu Ile 
    1040                 1045                 1050             


Val Arg  Asn Gly Ile Leu Ser  Pro Ser Phe Asn Phe  Tyr Leu Leu 
    1055                 1060                 1065             


Lys Gly  Val Ile Ile Lys Asn  Asn Leu Ala Ser Glu  Glu Glu Cys 
    1070                 1075                 1080             


Gln Trp  Phe Glu Gln Val His  Leu Asn Lys Thr Gln  Phe Tyr Pro 
    1085                 1090                 1095             


Glu Val  Ala Thr Lys Ser Thr  Ile Ile Gln Ser Ala  Tyr Leu Leu 
    1100                 1105                 1110             


Leu Leu  Ile Arg Asn Lys Met  Leu His Asn Gln Leu  
    1115                 1120                 1125 


<210>  1972
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1972

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1973
<211>  1145
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1973

Met Thr Leu Pro Thr Asp Asn Thr Phe Ile Glu Lys Ala Asp Gln Glu 
1               5                   10                  15      


Ile Leu Gly Lys Asn Lys Leu Phe Phe Gly Ala Tyr Leu Asn Met Ala 
            20                  25                  30          


Asn His Asn Ala Tyr Leu Ile Ile Lys Asp Ile Ser Glu Arg Leu Lys 
        35                  40                  45              


Gln Glu Asp Ala Leu Asp Ile Asp Ala Pro Ser Asp Glu Asp Asn Leu 
    50                  55                  60                  


Ala Tyr Ala Asp Ile Phe Ser Lys Ile Leu Lys Lys Ala Ser Asp Lys 
65                  70                  75                  80  


Asn Pro Lys Asn Arg Pro Gln Ala Thr Ile Ile Asp Lys Val Thr Asn 
                85                  90                  95      


Leu Leu Ile His His Phe Pro Ala Phe Glu Val Phe Ala Tyr Glu His 
            100                 105                 110         


Pro Phe Glu Gln Gln Asn Ser Tyr Pro Glu Leu Leu Tyr Gln Lys Leu 
        115                 120                 125             


Thr Thr Ala Leu Lys Leu Leu Asn Asp Leu Arg Asn Glu His Ser His 
    130                 135                 140                 


Phe Tyr Tyr Lys Gly Ser Phe Asp Ile Asp Thr Val Phe Ser Ala Ala 
145                 150                 155                 160 


Gln Glu Glu Ile Thr Arg Phe Pro Tyr Leu Thr Pro Glu Asp Ile Glu 
                165                 170                 175     


Glu Leu Glu Tyr Tyr Lys Asn Asp Leu Leu Glu Pro Leu Thr Tyr Phe 
            180                 185                 190         


Lys Lys Tyr Gly Phe Val Phe Phe Ile Cys Thr Phe Leu Glu Lys Arg 
        195                 200                 205             


Tyr Ala Arg Tyr Met Leu Lys Glu Lys Gln Leu Asp Leu Ile Ala Ser 
    210                 215                 220                 


Asp Lys Glu Arg Asp Ala Thr Leu Glu Asn Phe Thr Asn Tyr Ser Cys 
225                 230                 235                 240 


Arg Leu Pro Arg Pro Lys Leu Glu Ser Ser Val Ile Glu Leu Asp Met 
                245                 250                 255     


Leu Asn Glu Leu Ser Arg Cys Pro Lys Gly Ile His Asp Val Leu Ser 
            260                 265                 270         


Ser Pro Met Glu Lys Val Leu Leu Lys Thr Asp Ala Lys Asp Asp Pro 
        275                 280                 285             


Asn Gln Val Pro Met Ile Arg His Asn Asp Arg Phe Pro Tyr Phe Ala 
    290                 295                 300                 


Leu Ser Tyr Phe Asp Lys Met Glu Arg Phe Pro Ala Met Arg Phe His 
305                 310                 315                 320 


Ile Trp Ala Gly Lys Thr Arg Leu Ala Phe Tyr Gly Lys Lys Leu Gly 
                325                 330                 335     


Lys Lys Asn Val Leu Arg Asp Ile Gln Glu Asn Val Thr Ile Tyr Ala 
            340                 345                 350         


Arg Leu Asn Asp Ile Lys Ala Asp Lys Ile Pro Asp Asn Trp Lys Asp 
        355                 360                 365             


Lys Ile Asp Val Glu Asp Ser Glu Glu Asn Lys Glu Lys Ala Lys Ile 
    370                 375                 380                 


Gln Ser Tyr Ser Pro His Tyr Asn Ile His Asn Asn Arg Ile Ala Ile 
385                 390                 395                 400 


Lys Phe Ile Asp Thr Gln Lys Asp Glu Leu Asp Thr Glu Asn Phe Ser 
                405                 410                 415     


Glu Ile Lys Ser Lys Pro Gln Asp Pro Thr Lys Asp Lys Gln Leu Lys 
            420                 425                 430         


Tyr Thr Val Thr His Ala Leu Pro Asn Ala Ile Leu Ser Thr Tyr Glu 
        435                 440                 445             


Leu Gln Asn Leu Phe Leu Tyr Asp Tyr Leu Tyr Arg Thr Tyr Lys Asp 
    450                 455                 460                 


Gln Lys Val Leu Ala Arg Pro Ala Asp Ser Phe Ile Arg Asn Tyr Ile 
465                 470                 475                 480 


Ser Ser Phe His Arg Phe Cys Lys Asp Val Lys Ser Gly Lys Ile Gln 
                485                 490                 495     


Pro Val Ser Pro His Asp Phe Glu Arg Leu Thr Glu His Thr Arg Ser 
            500                 505                 510         


Thr Thr Arg Asp Leu Gly Asn Arg Glu Glu Glu Leu Glu Ile Arg Lys 
        515                 520                 525             


Glu Ala Leu Gln Lys Lys Lys Leu Asp Asn Tyr Gly Leu Lys Val Lys 
    530                 535                 540                 


Asn Leu Pro Asp Ala Leu Arg Glu Tyr Leu Leu Gly Tyr Lys Gln Glu 
545                 550                 555                 560 


Thr Tyr Thr Glu Ile Ala Leu Asn Lys Leu Arg Gly Lys Ile Lys Gln 
                565                 570                 575     


Thr Lys Val His Tyr Lys Leu Ala Thr Lys Asp Asp Leu Phe Leu Asp 
            580                 585                 590         


Gly Lys Thr Asp Leu Lys Ser Gly Lys Ile Gly Asp Phe Leu Ala Ala 
        595                 600                 605             


Asp Ile Val Phe Leu Lys Pro Leu Asp Ala Asn Arg Thr Gly Lys Pro 
    610                 615                 620                 


Asn Asn Gln Gln Phe Asn Glu Leu Gln Lys Ala Ile Ala Arg Phe His 
625                 630                 635                 640 


Ser Gln Lys Lys Asp Val Glu Asp Phe Ile Asn Glu Glu Leu Gln Ile 
                645                 650                 655     


Lys Glu Gln Ser Leu Pro His Ala His Pro Phe Leu Tyr Lys Ile Gln 
            660                 665                 670         


Phe Glu Glu His Thr Asp Val Gln Ser Phe Tyr Ile Lys Tyr Leu Glu 
        675                 680                 685             


Leu Lys Ile Glu Trp Leu Glu Cys Thr Lys Arg Glu Ile Gln Gly Lys 
    690                 695                 700                 


Ser Asp Tyr Leu Lys Pro Trp Gln Trp Arg Glu Glu Ala Asp Lys Cys 
705                 710                 715                 720 


Lys Gln Tyr Gly Ile Asp Ile Lys Pro Glu Gly Leu Ser Asp Ala Ala 
                725                 730                 735     


Thr Glu Asn Lys Tyr Gly Tyr Phe Leu Gln Ile Asn Thr Lys Lys Gly 
            740                 745                 750         


Asn Glu Arg Asn Tyr Thr Asn Ala Thr Thr Pro Ser Lys Ala Asn Ser 
        755                 760                 765             


Lys Glu Phe Glu Ser Leu Glu Ser Lys Ser Pro Val Ile Leu Pro Arg 
    770                 775                 780                 


Gly Leu Phe Asn Asp Ala Ile Ile Asp Ala Met Met Lys Ile Asp Glu 
785                 790                 795                 800 


Phe Lys Gly Lys Ile Lys Glu Gly Asp Asn Ile Val Arg Cys Leu Asp 
                805                 810                 815     


Val Leu Ala Glu Gly Asp Arg Gln Thr Phe Tyr Asp Phe Glu Arg Ser 
            820                 825                 830         


Tyr Thr Val Gly Lys Ala Ala Pro Thr Ser Val Thr Ile His Gln Gly 
        835                 840                 845             


Ala Asn Asp Glu Tyr Ile Lys Asn Lys Leu Arg Ser Ile Lys Pro Ile 
    850                 855                 860                 


Ile Lys Lys Leu Arg Thr Gln Gln Asn Ala Lys Asp Ala Lys Tyr Lys 
865                 870                 875                 880 


Asp Lys Lys Ile Leu Gln Asn His Ile Lys Ala Leu Gln Ala Ile Ser 
                885                 890                 895     


Asp Asn Glu Arg Ser Ile Arg Phe Ile Arg Ala Asn Asp Arg Ala Leu 
            900                 905                 910         


Phe Leu Met Ile Lys His Ile Phe Ser Glu His Lys Ser Tyr Val Val 
        915                 920                 925             


Glu Gly Ser Lys Leu Thr Lys Ser Ile Asn Thr Leu Pro Trp Lys Leu 
    930                 935                 940                 


Asn Lys Val Gly Tyr Glu Ile Lys Glu Asn Asn Ile Leu Asn Glu Ile 
945                 950                 955                 960 


Leu Pro Met Asn Ile Gln Phe Asn Gln Lys Asn Ile Tyr Thr Glu Gly 
                965                 970                 975     


Glu Tyr Gly Thr Asp Pro Leu Asn Lys Leu Ser Ile Lys His Tyr Gly 
            980                 985                 990         


Lys Phe Arg Lys Leu Leu Lys Asp  Lys Arg Leu Ser Asn  Lys Lys Lys 
        995                 1000                 1005             


Pro Gly  Leu Leu Asn Tyr Tyr  Thr Asp Gln Asn Val  Arg Trp Ser 
    1010                 1015                 1020             


Ala Ile  Asn Lys Glu Leu Glu  Tyr Tyr Asp Glu Asn  Arg Asp Arg 
    1025                 1030                 1035             


Leu Leu  Asp Val Ile Tyr Lys  Phe Glu Lys Ala Val  Trp Glu Asn 
    1040                 1045                 1050             


Glu Glu  Cys Arg Glu Glu Leu  Lys Glu Asn Ile Arg  Leu Gly Tyr 
    1055                 1060                 1065             


Ile Asn  His Ala Ala Gln Leu  Lys Ala Val Gly Lys  Ile Val Arg 
    1070                 1075                 1080             


Asp Phe  Thr Ala Ser Lys Gln  Asp Gln Leu Ala Leu  Leu Arg Asn 
    1085                 1090                 1095             


Lys Phe  Leu His Asn Gln Ile  Pro Tyr Thr Glu Asn  Leu Lys Thr 
    1100                 1105                 1110             


Gly Trp  Val Asp Asn Asn Pro  Glu Tyr Pro Leu Ile  Thr Gln Ala 
    1115                 1120                 1125             


Leu Leu  Glu Leu Ala Ile Ile  Glu Tyr Gln Asn Ile  Thr Lys Asn 
    1130                 1135                 1140             


Ile Ile  
    1145 


<210>  1974
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1974

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1975
<211>  1090
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1975

Met Lys Glu Glu Glu Ala Pro Val Val Ser Thr Tyr Asn Lys Asp Asp 
1               5                   10                  15      


Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val Tyr 
            20                  25                  30          


Ile Thr Ile Asn His Ile Asn Lys Ile Leu Gly Glu Ala Glu Ile Asn 
        35                  40                  45              


Ile Asp Gly Tyr Asp Ile Pro Leu Lys Asn Ile Trp Ser Gly Ile Arg 
    50                  55                  60                  


Asp Ile Asn Lys Lys Ala Arg Leu Glu Glu Leu Met Ile Lys His Phe 
65                  70                  75                  80  


Pro Phe Leu Glu Ala Met Thr His Gln Gln His Leu Thr Gly Asn Thr 
                85                  90                  95      


Lys Gln Lys Glu Glu Lys Gln Ala Glu Ile Gln Ser Phe Glu Ile Leu 
            100                 105                 110         


Lys Asp Asn Leu Phe Leu Leu Leu Lys Met Leu Gln Asp Leu Arg Asn 
        115                 120                 125             


His Tyr Ser His Tyr Lys His Ser Lys Ser Leu Glu Arg Pro Lys Phe 
    130                 135                 140                 


Asp Glu Asp Ile Arg Asn Lys Leu Tyr Asn Ile Leu Asp Thr Ser Ile 
145                 150                 155                 160 


Arg Leu Val Lys Glu Asp Tyr Lys His Asn Pro Asp Ile Lys Pro Lys 
                165                 170                 175     


Glu His Phe Lys His Leu Asp Arg Lys Arg Asn Glu Lys Phe Arg Tyr 
            180                 185                 190         


Ser Phe Ala Asp Asn Glu Gly Asn Ile Thr Ile Ser Gly Leu Leu Phe 
        195                 200                 205             


Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Val Gln Lys 
    210                 215                 220                 


Lys Leu Glu Gly Phe Arg Cys Ser Asn Glu Ser Tyr Gln Lys Met Thr 
225                 230                 235                 240 


Asn Glu Val Phe Cys Arg Asn Arg Ile Leu Leu Pro Lys Leu Arg Leu 
                245                 250                 255     


Glu Ser Thr Gln Thr Lys Asp Trp Ile Leu Leu Asp Met Leu Asn Glu 
            260                 265                 270         


Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Lys Gly Glu Asp 
        275                 280                 285             


Arg Lys Lys Phe Glu Val Pro Phe Asp Ser Thr Asp Glu Asp Tyr Asp 
    290                 295                 300                 


Ala Glu Gln Asp Pro Phe Lys Asn Thr Leu Ile Arg His Gln Asp Arg 
305                 310                 315                 320 


Phe Pro Tyr Phe Val Leu Arg Tyr Ser Asp Tyr Asn Glu Ile Phe Glu 
                325                 330                 335     


Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile Tyr 
            340                 345                 350         


Lys Lys Leu Ile Gly Gly Glu Lys Glu Asp Arg His Leu Thr His Lys 
        355                 360                 365             


Leu Tyr Gly Phe Glu Arg Leu Gln Glu Phe Ala Lys Gln Asn Arg Pro 
    370                 375                 380                 


Asp Glu Trp Lys Ala Ile Ile Lys Asp Leu Asp Thr Phe Lys Lys Gln 
385                 390                 395                 400 


Glu Asp Glu Lys Val Asn Glu Lys Pro Tyr Ile Ser Glu Thr Thr Pro 
                405                 410                 415     


His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Ala Phe Lys Asn His 
            420                 425                 430         


Asn Ile Trp Pro Ser Thr Asn Thr Glu Leu Thr Asn Asn Lys Arg Lys 
        435                 440                 445             


Lys Tyr Asn Leu Arg Thr Ser Ile Lys Ala Glu Ala Phe Leu Ser Val 
    450                 455                 460                 


His Glu Leu Leu Pro Met Met Phe Tyr Tyr Met Leu Leu Lys Thr Lys 
465                 470                 475                 480 


Asn Glu Ser Pro Arg Lys Val Glu Ala Ile Ile Glu Ser Lys Ile Lys 
                485                 490                 495     


Asp Ile Phe Thr Leu Tyr Asp Ala Phe Ala Asn Asp Glu Ile Asp Asn 
            500                 505                 510         


Thr Asp Glu Leu Glu Lys Tyr Cys Glu Asp Lys Asp Ile Lys Ile Gly 
        515                 520                 525             


His Leu Pro Lys Gln Met Ile Ala Ile Leu Tyr Asn Lys His Lys Asp 
    530                 535                 540                 


Met Val Glu Lys Ala Lys Val Lys Gln Glu Lys Met Lys Leu Ala Thr 
545                 550                 555                 560 


Glu Asn Arg Leu Lys Thr Leu Asp Lys Leu Ile Glu Gly Lys Met Lys 
                565                 570                 575     


Tyr Ala Lys Arg Gly Ile Ser Pro Leu Lys Ser Gly Glu Ile Ala Ser 
            580                 585                 590         


Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln Arg Asp Glu 
        595                 600                 605             


Asn Gly Glu Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln 
    610                 615                 620                 


Leu Leu Gln Arg Thr Leu Ala Leu Phe Gly Ser Glu His Glu Arg Leu 
625                 630                 635                 640 


Thr Pro Tyr Phe Lys Gln Met Asn Leu Ile Gly Asp Thr Asn Ser His 
                645                 650                 655     


Pro Phe Leu Lys Gln Thr Glu Trp Glu Lys Cys Asn Asn Ile Leu Ser 
            660                 665                 670         


Phe Tyr Arg Asn Tyr Leu Lys Ala Lys Ile Glu Phe Leu Asn Lys Leu 
        675                 680                 685             


Lys Pro Glu Asp Trp Lys Lys Asn Gln Cys Phe Leu Lys Leu Lys Glu 
    690                 695                 700                 


Pro Lys Thr Asn Arg Asp Thr Leu Val Gln Gly Trp Lys Asn Gly Phe 
705                 710                 715                 720 


Asn Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg Lys Trp Phe Ile 
                725                 730                 735     


Lys Tyr Trp Lys Lys Ile Lys Val Asp Asp Leu Lys Arg Val Gly Leu 
            740                 745                 750         


Val Ala Lys Val Ile Pro Leu Phe Phe Ser Glu Lys Tyr Lys Asp Ser 
        755                 760                 765             


Val Gln Pro Phe Tyr Asn Tyr Pro Phe Asn Val Gly Asn Ile Asp Lys 
    770                 775                 780                 


Pro Lys Glu Lys Asp Phe Leu Asp Ile Ala Arg Arg Arg Lys Leu Trp 
785                 790                 795                 800 


Asp Lys Lys Gln Leu Glu Phe Lys Gly Lys Thr Glu Glu Glu Lys Arg 
                805                 810                 815     


Lys Asn Pro Ser Tyr Leu Asp Phe Lys Ser Trp Lys Lys Phe Glu Arg 
            820                 825                 830         


Glu Ile Arg Leu Thr Arg Asn Gln Asp Ile Val Thr Trp Leu Met Cys 
        835                 840                 845             


Ile Glu Ile Tyr Asn Asn Gln Lys Val Glu Asn Leu Asn Thr Gly His 
    850                 855                 860                 


Ile Tyr Leu Lys Asp Ile Ile Thr Asn Val Glu Glu Glu Arg Ser Asn 
865                 870                 875                 880 


Asn Ile Leu Asn Gln Ile Lys Ser Met Gln Leu Pro Val Thr Val Tyr 
                885                 890                 895     


Glu Asn Glu Ser Ser Pro Lys Lys Lys Tyr Leu Arg Thr Ile Tyr Ile 
            900                 905                 910         


Glu Glu Asn Gly Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu 
        915                 920                 925             


Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Val Lys Thr Asn 
    930                 935                 940                 


Ser Glu Ala Glu Ser Lys Arg Asn Pro Ile Ser Lys Leu Arg Val Glu 
945                 950                 955                 960 


His Glu Leu Arg Glu Tyr Gln Lys Ala Arg Ile Glu Ile Ile Lys Asp 
                965                 970                 975     


Met Leu Ala Leu Glu Lys Thr Leu Ile Asp Asn Tyr Asp Ser Leu Asp 
            980                 985                 990         


Thr Asp Asn Phe His Asn Met Leu  Thr Gly Trp Leu Glu  Leu Lys Gly 
        995                 1000                 1005             


Glu Val  Asn Lys Ala Lys Phe  Asn Asn Asp Val Lys  Leu Leu Thr 
    1010                 1015                 1020             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1025                 1030                 1035             


Glu Asn  Leu Phe Val Asn Ile  Glu Arg Phe Ser Leu  Ser Ser Ser 
    1040                 1045                 1050             


Lys Ile  Leu Glu Ser Lys Gly  Leu Ser Ile Ala Val  Lys Leu Lys 
    1055                 1060                 1065             


Glu Glu  Val Ser Lys Ile Ile  Lys Lys Ile Gln Glu  Glu Glu Asp 
    1070                 1075                 1080             


Gly Lys  Lys Glu Lys Glu Thr  
    1085                 1090 


<210>  1976
<211>  948
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1976

Leu Phe Phe Ser Phe His Asn Ala Gln Arg Val Ile Phe Lys His Leu 
1               5                   10                  15      


Tyr Lys Ala Phe Asp Ala Ser Leu Arg Met Val Lys Glu Asp Tyr Lys 
            20                  25                  30          


Ala His Phe Thr Val Asn Leu Thr Arg Asp Phe Ala His Leu Asn Arg 
        35                  40                  45              


Lys Gly Lys Asn Lys Gln Asp Asn Pro Asp Phe Asn Arg Tyr Arg Phe 
    50                  55                  60                  


Glu Lys Asp Gly Phe Phe Thr Glu Ser Gly Leu Leu Phe Phe Thr Asn 
65                  70                  75                  80  


Leu Phe Leu Asp Lys Arg Asp Ala Tyr Trp Met Leu Lys Lys Val Ser 
                85                  90                  95      


Gly Phe Lys Ala Ser His Lys Gln Arg Glu Lys Met Thr Thr Glu Val 
            100                 105                 110         


Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu Glu Ser Arg 
        115                 120                 125             


Tyr Asp His Asn Gln Met Leu Leu Asp Met Leu Ser Glu Leu Ser Arg 
    130                 135                 140                 


Cys Pro Lys Leu Leu Tyr Glu Lys Leu Ser Glu Glu Asn Lys Lys His 
145                 150                 155                 160 


Phe Gln Val Glu Ala Asp Gly Phe Leu Asp Glu Ile Glu Glu Glu Gln 
                165                 170                 175     


Asn Pro Phe Lys Asp Thr Leu Ile Arg His Gln Asp Arg Phe Pro Tyr 
            180                 185                 190         


Phe Ala Leu Arg Tyr Leu Asp Leu Asn Glu Ser Phe Lys Ser Ile Arg 
        195                 200                 205             


Phe Gln Val Asp Leu Gly Thr Tyr His Tyr Cys Ile Tyr Asp Lys Lys 
    210                 215                 220                 


Ile Gly Asp Glu Gln Glu Lys Arg His Leu Thr Arg Thr Leu Leu Ser 
225                 230                 235                 240 


Phe Gly Arg Leu Gln Asp Phe Thr Glu Ile Asn Arg Pro Gln Glu Trp 
                245                 250                 255     


Lys Ala Leu Thr Lys Asp Leu Asp Tyr Lys Glu Thr Ser Asn Gln Pro 
            260                 265                 270         


Phe Ile Ser Lys Thr Thr Pro His Tyr His Ile Thr Asp Asn Lys Ile 
        275                 280                 285             


Gly Phe Arg Leu Gly Thr Ser Lys Glu Leu Tyr Pro Ser Leu Glu Ile 
    290                 295                 300                 


Lys Asp Gly Ala Asn Arg Ile Ala Lys Tyr Pro Tyr Asn Ser Gly Phe 
305                 310                 315                 320 


Val Ala His Ala Phe Ile Ser Val His Glu Leu Leu Pro Leu Met Phe 
                325                 330                 335     


Tyr Gln His Leu Thr Gly Lys Ser Glu Asp Leu Leu Lys Glu Thr Val 
            340                 345                 350         


Arg His Ile Gln Arg Ile Tyr Lys Asp Phe Glu Glu Glu Arg Ile Asn 
        355                 360                 365             


Thr Ile Glu Asp Leu Glu Lys Ala Asn Gln Gly Arg Leu Pro Leu Gly 
    370                 375                 380                 


Ala Phe Pro Lys Gln Met Leu Gly Leu Leu Gln Asn Lys Gln Pro Asp 
385                 390                 395                 400 


Leu Ser Glu Lys Ala Lys Ile Lys Ile Glu Lys Leu Ile Ala Glu Thr 
                405                 410                 415     


Lys Leu Leu Ser His Arg Leu Asn Thr Lys Leu Lys Ser Ser Pro Lys 
            420                 425                 430         


Leu Gly Lys Arg Arg Glu Lys Leu Ile Lys Thr Gly Val Leu Ala Asp 
        435                 440                 445             


Trp Leu Val Lys Asp Phe Met Arg Phe Gln Pro Val Ala Tyr Asp Ala 
    450                 455                 460                 


Gln Asn Gln Pro Ile Lys Ser Ser Lys Ala Asn Ser Thr Glu Phe Trp 
465                 470                 475                 480 


Phe Ile Arg Arg Ala Leu Ala Leu Tyr Gly Gly Glu Lys Asn Arg Leu 
                485                 490                 495     


Glu Gly Tyr Phe Lys Gln Thr Asn Leu Ile Gly Asn Thr Asn Pro His 
            500                 505                 510         


Pro Phe Leu Asn Lys Phe Asn Trp Lys Ala Cys Arg Asn Leu Val Asp 
        515                 520                 525             


Phe Tyr Gln Gln Tyr Leu Glu Gln Arg Glu Lys Phe Leu Glu Ala Ile 
    530                 535                 540                 


Lys Asn Gln Pro Trp Glu Pro Tyr Gln Tyr Cys Leu Leu Leu Lys Ile 
545                 550                 555                 560 


Pro Lys Glu Asn Arg Lys Asn Leu Val Lys Gly Trp Glu Gln Gly Gly 
                565                 570                 575     


Ile Ser Leu Pro Arg Gly Leu Phe Thr Glu Ala Ile Arg Glu Thr Leu 
            580                 585                 590         


Ser Glu Asp Leu Met Leu Ser Lys Pro Ile Arg Lys Glu Ile Lys Lys 
        595                 600                 605             


His Gly Arg Val Gly Phe Ile Ser Arg Ala Ile Thr Leu Tyr Phe Lys 
    610                 615                 620                 


Glu Lys Tyr Gln Asp Lys His Gln Ser Phe Tyr Asn Leu Ser Tyr Lys 
625                 630                 635                 640 


Leu Glu Ala Lys Ala Pro Leu Leu Lys Arg Glu Glu His Tyr Glu Tyr 
                645                 650                 655     


Trp Gln Gln Asn Lys Pro Gln Ser Pro Thr Glu Ser Gln Arg Leu Glu 
            660                 665                 670         


Leu His Thr Ser Asp Arg Trp Lys Asp Tyr Leu Leu Tyr Lys Arg Trp 
        675                 680                 685             


Gln His Leu Glu Lys Lys Leu Arg Leu Tyr Arg Asn Gln Asp Val Met 
    690                 695                 700                 


Leu Trp Leu Met Thr Leu Glu Leu Thr Lys Asn His Phe Lys Glu Leu 
705                 710                 715                 720 


Asn Leu Asn Tyr His Gln Leu Lys Leu Glu Asn Leu Ala Val Asn Val 
                725                 730                 735     


Gln Glu Ala Asp Ala Lys Leu Asn Pro Leu Asn Gln Thr Leu Pro Met 
            740                 745                 750         


Val Leu Pro Val Lys Val Tyr Pro Ala Thr Ala Phe Gly Glu Val Gln 
        755                 760                 765             


Tyr His Lys Thr Pro Ile Arg Thr Val Tyr Ile Arg Glu Glu His Thr 
    770                 775                 780                 


Lys Ala Leu Lys Met Gly Asn Phe Lys Ala Leu Val Lys Asp Arg Arg 
785                 790                 795                 800 


Leu Asn Gly Leu Phe Ser Phe Ile Lys Glu Glu Asn Asp Thr Gln Lys 
                805                 810                 815     


His Pro Ile Ser Gln Leu Arg Leu Arg Arg Glu Leu Glu Ile Tyr Gln 
            820                 825                 830         


Ser Leu Arg Val Asp Ala Phe Lys Glu Thr Leu Ser Leu Glu Glu Lys 
        835                 840                 845             


Leu Leu Asn Lys His Thr Ser Leu Ser Ser Leu Glu Asn Glu Phe Arg 
    850                 855                 860                 


Ala Leu Leu Glu Glu Trp Lys Lys Glu Tyr Ala Ala Ser Ser Met Val 
865                 870                 875                 880 


Thr Asp Glu His Ile Ala Phe Ile Ala Ser Val Arg Asn Ala Phe Cys 
                885                 890                 895     


His Asn Gln Tyr Pro Phe Tyr Lys Glu Ala Leu His Ala Pro Ile Pro 
            900                 905                 910         


Leu Phe Thr Val Ala Gln Pro Thr Thr Glu Glu Lys Asp Gly Leu Gly 
        915                 920                 925             


Ile Ala Glu Ala Leu Leu Lys Val Leu Arg Glu Tyr Cys Glu Ile Val 
    930                 935                 940                 


Lys Ser Gln Ile 
945             


<210>  1977
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1977

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1978
<211>  1140
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1978

Met Glu Asn Asp Gln Gln Ile Leu Glu Asn Arg Arg Arg Thr Leu Ala 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Ser Asn His Leu Ala Thr Ser Phe Glu Gln Lys Ala 
        35                  40                  45              


Leu His Glu Glu Gly Gln Ile Pro Ala Ser Phe Leu Cys Asn Lys Ser 
    50                  55                  60                  


Ile Lys Lys Ile Asn Trp Asn His Val Tyr Ser Lys Ala Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Ile Phe Asp Ala Asp Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Arg Glu Thr Ser Asp Lys Glu Gly Lys Asp Phe Thr Ala Met Asn Glu 
            100                 105                 110         


Thr Leu Lys Leu Val Phe Asp Glu Leu Gln Ala Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Ala Asp Ser Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Val Glu Leu Ala Asp Phe Leu Thr Val Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Ala Asp Asp Asp Tyr 
                165                 170                 175     


Ala Val Val Glu Ser Lys Gln Ile Val Thr Pro Asp Asn Gln Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Ile Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Val Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Leu Ala Tyr Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asp Leu Arg Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Glu 
            260                 265                 270         


Val Ile Thr Glu Glu Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Glu Glu Glu Arg 
    290                 295                 300                 


Glu Lys Ile Leu Asp Glu Ile Asp Tyr Glu Asp Tyr Ile Glu Ser Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg His Ser Asn Arg Phe Pro Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Glu Lys Tyr Asn Lys Gln Phe Asp Gly Glu 
        355                 360                 365             


Ala Thr Glu Arg Lys Val Val Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asn Gln Glu Thr Val Glu Leu Lys Ile Asp Ser Ala 
385                 390                 395                 400 


Gln Arg Thr Asn Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Glu Ala Arg Leu Leu 
            420                 425                 430         


Thr Lys Ala Lys Pro Glu Ser Lys Val Ser Tyr Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Lys Ala Glu Glu Met Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Lys Val Asn Asp Ser Gln Leu Met Asn Met Gln Phe Ile Asp Glu 
                485                 490                 495     


Ile Lys Glu Gln Leu Pro Ala Asp Trp Asn Glu Phe Gly Lys Arg Ser 
            500                 505                 510         


Asp Ser Lys Lys Lys Lys Ala Tyr Thr Asn Ala Ala Arg Gln Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Lys Val Leu Ala Asn Tyr Gln Leu 
    530                 535                 540                 


Asn Asp Lys Gln Val Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Val 
545                 550                 555                 560 


Lys Glu Val Asp Asp Ser Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Met Glu Lys His Lys Val 
            580                 585                 590         


Asp Lys Ser Ala Arg Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Thr Asp Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Tyr 
625                 630                 635                 640 


Ala Asp Asn Glu Lys Lys Ala Thr Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Lys Asp Gly His Pro Phe Leu Ala Asn Ile Asn 
            660                 665                 670         


Leu Arg Gln Ile Arg Lys Thr Ser Gln Leu Tyr Glu Leu Tyr Leu Val 
        675                 680                 685             


Glu Lys Ala Asn Lys Gln Val Lys Lys Met Asn Pro Lys Thr Gln Arg 
    690                 695                 700                 


Thr Asn Asn Val Asp Glu Ser Trp Met Met Lys Ser Phe Tyr Ala Lys 
705                 710                 715                 720 


Glu Trp Asn Glu Glu Met Gly Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Thr Asn Ile Pro Phe Thr Ile Arg Gln Trp Glu Glu Lys 
            740                 745                 750         


Glu Lys His Asn Leu Gln Ala Trp Leu His Asn Ile Thr Lys Gly Lys 
        755                 760                 765             


Thr Ser Lys Asp Gly Lys Lys Ala Val Asp Leu Pro Thr Asn Leu Phe 
    770                 775                 780                 


Asp Asp Thr Leu Cys Glu Leu Leu Arg Glu Ala Leu Ile Asn Glu Gly 
785                 790                 795                 800 


Ile Asp Ala Thr Pro Thr Thr Lys Tyr Asn Glu Leu Leu Lys His Trp 
                805                 810                 815     


Trp Thr Ala Arg Glu Asp Ser Thr Gln Asp Phe Tyr Leu Ser Glu Arg 
            820                 825                 830         


Gln Tyr Asp Ile Tyr Asp Glu Lys Val Cys Phe Thr Ile Asn Ser Ser 
        835                 840                 845             


Ala His Phe Ala Asp Tyr Tyr Ala Pro Ala Leu Ser Lys Ala Tyr Ser 
    850                 855                 860                 


Arg Leu Arg Ala Glu Arg Asp Val Ala Arg Arg Thr Asp Lys Arg Leu 
865                 870                 875                 880 


Pro Pro Val Glu Arg Lys Asp Val Glu Arg Val Phe Lys Asn Thr Ile 
                885                 890                 895     


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
            900                 905                 910         


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asn Gln Gln Gln Leu Lys 
        915                 920                 925             


Leu Ser Lys Met Asp Ser Leu Leu Asn Glu Thr Lys Arg Ile Glu Gln 
    930                 935                 940                 


Val Ile Asn Thr Gln Leu Ser Phe Asp Gln Lys Gly Lys Glu Ile Lys 
945                 950                 955                 960 


Asp Lys Thr Asn Leu Glu Ile Val Lys Thr Ile Val Ala Glu Arg Lys 
                965                 970                 975     


Gln Lys Asn Tyr Thr Glu Met Arg Lys Tyr Val His Asp Arg Arg Leu 
            980                 985                 990         


Pro Glu Leu Phe Glu Tyr Ile Asp  Gly Asn Glu Leu Pro  Leu Asp Met 
        995                 1000                 1005             


Leu Leu  Asn Glu Leu Arg Ala  Tyr Asn Thr Ala Lys  Gln Val Val 
    1010                 1015                 1020             


Phe Asp  Thr Val Phe Ala Leu  Glu Lys Lys Ile Ile  Glu Thr Asp 
    1025                 1030                 1035             


Pro Glu  Gly Leu Lys Gln Leu  Asn Val Ser Lys Asp  Gly Gln Ile 
    1040                 1045                 1050             


Gln Thr  Gly Asn Ile Gln His  Lys Pro Tyr Val Gln  Trp Leu Glu 
    1055                 1060                 1065             


Asn Lys  Gly Leu Ile Thr Asp  Lys Asp Lys Gln Phe  Ile Asn Met 
    1070                 1075                 1080             


Val Arg  Asn Ser Phe Ser His  Asn Gln Phe Pro Gln  Arg Ser Thr 
    1085                 1090                 1095             


Val Glu  Leu Leu Met Pro Val  Trp Gln Asn Thr Asn  Ile Ala Leu 
    1100                 1105                 1110             


Gln Ile  Ala Arg Glu Tyr Gln  Gln Leu Ile Val Asp  Ile Ile Glu 
    1115                 1120                 1125             


Lys Ser  Leu His Pro His Lys  Gln His Gln Met Val  
    1130                 1135                 1140 


<210>  1979
<211>  1128
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1979

Met Glu Thr Gln Ile Ser Asn Ile Glu Asn Lys Tyr Arg Ile Leu Asn 
1               5                   10                  15      


Asp Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Val Phe Asn Ile Ser Asn His Ile Ala Lys Glu Phe Asn Leu Pro Leu 
        35                  40                  45              


Leu Pro Glu Glu Gly His Leu Lys Asn Ser Phe Leu Cys Gln Lys Glu 
    50                  55                  60                  


Asn Lys Lys Val Asn Trp Asn His Ile Phe Ser Lys Thr Asn Arg Phe 
65                  70                  75                  80  


Leu Ser Ile Leu Lys Val Phe Asp Val Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Lys Met Thr Asp Ser Glu Gly Lys Asp Phe Ala Leu Met Ser Asp 
            100                 105                 110         


Ser Leu Lys Ile Val Phe Gly Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Asn Gly Thr Ser Arg Lys Thr Thr Val 
    130                 135                 140                 


Ser Asp Glu Met Ser Leu Phe Leu Arg Thr Asn Phe Leu Arg Ala Ile 
145                 150                 155                 160 


Gln Tyr Thr Lys Glu Arg Phe Lys Gly Val Leu Asn Asp Glu Asp Tyr 
                165                 170                 175     


Gln Leu Val Ala Ser Lys Lys Val Leu Glu Ala Asp Asn Thr Ile Thr 
            180                 185                 190         


Val Glu Gly Leu Val Phe Leu Thr Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Thr Gly Leu Lys Gly Thr Gln Asn 
    210                 215                 220                 


Asn Ser Phe Ile Ser Thr Arg Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro His Asp Arg Phe Gln Ser Asp Asp Thr Arg Gln Ala Phe Ser 
                245                 250                 255     


Leu Asp Leu Ile Asn Glu Leu Thr Arg Cys Pro Lys Glu Leu Tyr Asn 
            260                 265                 270         


Ala Ile Thr Glu Glu Gly Lys Met Lys Phe Gln Pro Lys Leu Asp Glu 
        275                 280                 285             


Pro Gly Ile Lys Asn Leu Leu Asp Asn Ser Thr Asn Asn Lys Lys Lys 
    290                 295                 300                 


Ile Asp Ala Glu Asp Tyr Asp Glu Tyr Ile Glu Ser Leu Thr Lys Arg 
305                 310                 315                 320 


Ile Arg Tyr Asn Asn Arg Phe Ser Asp Phe Ala Leu Lys Tyr Ile Glu 
                325                 330                 335     


Glu Thr Asp Ile Leu Gly Asp Phe Arg Phe Gln Ile Asp Leu Gly Lys 
            340                 345                 350         


Leu Phe Val Asp Glu Tyr Asp Lys Phe Phe Asn Gly Glu Glu Val Pro 
        355                 360                 365             


Arg Arg Ile Ile Glu Asn Val Lys Ala Phe Gly Lys Leu Asn Asp Phe 
    370                 375                 380                 


Asn Asp Glu Ser Ile Leu Leu Ala Gln Ile Glu Asn Gly Tyr Pro Ser 
385                 390                 395                 400 


Lys Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Thr Glu Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Val Lys Val Asp Thr Ala Lys Leu Arg Ser Asn Ser 
            420                 425                 430         


Lys Gly Glu Pro Gly Lys Asn Leu Asn Gln Pro Leu Pro Glu Ala Phe 
        435                 440                 445             


Leu Ser Leu Asn Glu Leu Pro Lys Ile Ile Leu Leu Asp Tyr Leu Gln 
    450                 455                 460                 


Lys Gly Glu Pro Glu Gln Leu Ile Asn Asp Phe Ile Leu Ile Asn Asn 
465                 470                 475                 480 


Ser Lys Leu Met Lys Met Ser Phe Ile Glu Glu Ile Lys Asn Leu Leu 
                485                 490                 495     


Pro Lys Glu Trp Asn Glu Phe Arg Lys Arg Ala Asp Thr Arg Lys Gln 
            500                 505                 510         


Ala Ala Tyr Asn Asn Glu Thr Leu Ala Tyr Leu Leu Glu Arg Lys Gln 
        515                 520                 525             


Ile Leu Asn Gln Val Leu Val Ser Tyr Gln Leu Asn Asp Lys Gln Ile 
    530                 535                 540                 


Pro Gly Arg Ile Leu Asp Tyr Trp Leu Asn Ile Lys Glu Val Glu Glu 
545                 550                 555                 560 


Gly Arg Ala Val Ser Asp Arg Leu Lys Leu Met Lys Arg Asp Cys Met 
                565                 570                 575     


Ser Arg Leu Lys Ala Leu Glu Lys Phe Lys Ile Asp Arg Asn Arg Ser 
            580                 585                 590         


Lys Ile Pro Lys Thr Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile 
        595                 600                 605             


Val Asp Met Val Val Ser Glu Gly Ile Lys Lys Lys Ile Thr Ser Phe 
    610                 615                 620                 


Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Pro Glu 
625                 630                 635                 640 


Lys Lys Arg Leu Phe Ile His Ile Val Ile Arg Glu Leu Arg Leu Asn 
                645                 650                 655     


Gly Thr Gly Gly His Pro Phe Leu Phe Gln Leu Asn Phe Asp Lys Ile 
            660                 665                 670         


Asn Cys Thr Ser Asp Phe Tyr Ser Glu Tyr Leu Arg Glu Lys Gly His 
        675                 680                 685             


Lys Met Val Lys Glu Lys Asn Leu Lys Thr Gly Lys Ile Val Leu Thr 
    690                 695                 700                 


Asp His Ser Trp Met Ala Leu Thr Phe Tyr Lys Leu Glu Phe Asn Asp 
705                 710                 715                 720 


Lys Val Asp Lys Leu Met Thr Val Val Lys Leu Pro Leu Asn Lys Leu 
                725                 730                 735     


Asn Ile Pro Phe Thr Leu Arg Gln Leu Glu Gly Lys Thr Ile Asn Thr 
            740                 745                 750         


Leu Glu Gln Trp Leu His Asn Ile Thr Lys Gly Lys Asn Leu Asn Asp 
        755                 760                 765             


Gly Lys His Pro Val Asn Leu Pro Thr Asn Leu Phe Asp Glu Arg Leu 
    770                 775                 780                 


Thr Ala Cys Leu Gln Lys Glu Leu Asp Lys Lys Gln Ile Ile Tyr Pro 
785                 790                 795                 800 


Pro Tyr Ala Asn Trp Asn Glu Leu Phe Lys Thr Trp Trp Lys Ser Arg 
                805                 810                 815     


Asn Asp Ser Thr Gln Ser Phe Tyr Asn Ala Glu Arg Glu Tyr Ile Ile 
            820                 825                 830         


Phe Asp Glu Lys Val Asn Phe Tyr Pro Asn Arg Gln Glu Lys Phe Ala 
        835                 840                 845             


Asp Tyr Tyr His His Ala Val Lys Ala Ala Tyr Gln Lys Lys Arg Asn 
    850                 855                 860                 


Glu Arg Thr Leu Gln Gln Lys Asp Asp Lys His Leu Pro Asp Ile Leu 
865                 870                 875                 880 


Phe Ala Gln Val Glu Lys Thr Phe Lys Gln Thr Ile Ala Gly Thr Glu 
                885                 890                 895     


Lys Glu Ile Arg Met Val Gln Glu Glu Asp Arg Ile Met Leu Val Met 
            900                 905                 910         


Leu Glu Ser Leu Leu Glu Asp Gly Lys Lys Leu Gln Leu Lys Leu Ser 
        915                 920                 925             


Glu Ile Asn Thr Leu Leu Asn Ala Thr Thr Glu Ile Lys Gln Val Val 
    930                 935                 940                 


Thr Ala Lys Leu Ser Phe Asn Asp Ser Gly Glu Ile Ile Lys Asp Lys 
945                 950                 955                 960 


Thr Asn Pro Glu Ile Thr Lys Thr Ile Thr Ala Val Arg Lys Arg Lys 
                965                 970                 975     


Asp Tyr Ser Val Leu Arg Lys Phe Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Gly Tyr Phe Asp Gly Asp  Glu Ile Gln Phe Glu  Ser Leu Lys 
        995                 1000                 1005             


Ala Glu  Leu Asp Ala Tyr Asn  Lys Ala Lys Gln Glu  Val Leu Asp 
    1010                 1015                 1020             


Val Val  Phe Lys Leu Glu Lys  Lys Ile Ile Ala Lys  Asp Cys Asn 
    1025                 1030                 1035             


Gly Val  Gln Gln Leu Phe Ser  Asp Glu Thr Gly Asn  Leu Leu Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Thr Trp Leu  Lys Ser Lys 
    1055                 1060                 1065             


Gly Leu  Ile Gly Asp Ser Thr  Phe Thr Phe Leu Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Cys  Phe Ser His Asn Gln  Tyr Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Arg Phe  Ile Asp His Trp Glu  Thr Asn Arg Phe Ala  Leu Thr Ile 
    1100                 1105                 1110             


Ala Thr  Lys Tyr Asn His Glu  Ile Thr Arg Ile Met  Glu Lys Ile 
    1115                 1120                 1125             


<210>  1980
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1980

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1981
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1981

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Met Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Met Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1982
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1982

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Met Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Met Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1983
<211>  985
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1983

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Asn Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys Gly Tyr 
                165                 170                 175     


Ala Phe Phe Ile Ser Lys Phe Leu Glu Arg Lys Tyr Ser Tyr Leu Phe 
            180                 185                 190         


Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln Tyr Arg 
        195                 200                 205             


Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro Val Glu 
    210                 215                 220                 


Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu Asp Ile 
225                 230                 235                 240 


Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr Leu Glu 
                245                 250                 255     


Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr Asp Ala 
            260                 265                 270         


Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe Arg Ser 
        275                 280                 285             


Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala Asp Phe 
    290                 295                 300                 


Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His Asn Gly 
305                 310                 315                 320 


Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr Ile Asn 
                325                 330                 335     


Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser Ala Lys 
            340                 345                 350         


Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser Thr Asp 
        355                 360                 365             


Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln Ser Thr 
    370                 375                 380                 


Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val Leu Pro 
385                 390                 395                 400 


Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala Lys Met 
                405                 410                 415     


Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala Met Leu 
            420                 425                 430         


Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His Cys Pro 
        435                 440                 445             


Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser Thr Lys 
    450                 455                 460                 


Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg Val Met 
465                 470                 475                 480 


Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu Arg Ile 
                485                 490                 495     


Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile Leu Lys 
            500                 505                 510         


Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp Leu Gln 
        515                 520                 525             


Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn Phe Gln 
    530                 535                 540                 


Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn Asp Leu 
545                 550                 555                 560 


Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn Pro His 
                565                 570                 575     


Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile Glu Phe 
            580                 585                 590         


Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg Ile Gln 
        595                 600                 605             


Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro Leu Arg 
    610                 615                 620                 


Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu Ala Ile 
625                 630                 635                 640 


Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys Leu Lys 
                645                 650                 655     


Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu Lys Ser 
            660                 665                 670         


Pro Ala Leu Asn Val Ser Tyr Leu Ile His Asn Tyr Phe Arg Ala Tyr 
        675                 680                 685             


Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn Tyr Arg 
    690                 695                 700                 


Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser Tyr Leu 
705                 710                 715                 720 


Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro Ser Lys 
                725                 730                 735     


Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp Arg Leu 
            740                 745                 750         


Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile Ile Arg 
        755                 760                 765             


Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys Glu Tyr 
    770                 775                 780                 


Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu Glu Asn 
785                 790                 795                 800 


Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp Leu Asn 
                805                 810                 815     


Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr Gly Lys 
            820                 825                 830         


Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn Lys Val 
        835                 840                 845             


Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val Lys Ile 
    850                 855                 860                 


Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu Glu Ala 
865                 870                 875                 880 


Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala Met Val 
                885                 890                 895     


Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr Tyr Asp 
            900                 905                 910         


Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln Lys Ile 
        915                 920                 925             


Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His Asp Lys 
    930                 935                 940                 


Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val Tyr Ala 
945                 950                 955                 960 


Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile Lys Leu 
                965                 970                 975     


Glu Asp Leu Ser Asn Asp Ser Ser Ala 
            980                 985 


<210>  1984
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1984

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Pro 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Met Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Met Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Ala Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1985
<211>  1171
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1985

Met Asn Leu Leu Glu Lys Thr Asn Ala Ala Glu Ser Cys Phe Asn His 
1               5                   10                  15      


Thr Ile Asn Asp Gln Lys Tyr Tyr Phe Ala Gly Tyr Leu Asn Leu Ala 
            20                  25                  30          


Gln Asn Asn Ile Lys Thr Leu Glu Lys Ala Tyr Gly Glu His Phe Leu 
        35                  40                  45              


Cys Ser Gly Asn Asn Pro Ile Ile Asn Asp Leu Thr Asn Thr Asn Ser 
    50                  55                  60                  


Leu Ile Asp Trp Asp Phe Lys Met Lys Phe Leu Ser Gln Tyr Leu Pro 
65                  70                  75                  80  


Ala Ile Ser Tyr Leu Asn Leu Glu Thr Asp Leu Asn Glu Ser Phe Glu 
                85                  90                  95      


Lys Arg Lys Lys Glu Phe Thr Lys Asn Leu Ser Phe Leu Phe Asn Ala 
            100                 105                 110         


Ile Asp Leu Leu Arg Asn Phe Tyr Ser His Tyr Tyr His Ala Pro Leu 
        115                 120                 125             


Ile Asp Glu Leu Asn Ser Glu Arg Leu Ile Phe Leu Asp Lys Ile Phe 
    130                 135                 140                 


Val Ala Val Cys Ile Asn Val Lys Lys Lys Arg Met Lys Asp Asp Lys 
145                 150                 155                 160 


Thr Lys Gln Leu Leu Lys Ala Thr Leu Ile Asp Glu Leu Asp Leu Leu 
                165                 170                 175     


Leu Lys Ala Lys Lys Glu Glu Leu Leu Lys Lys Lys Lys Glu Gly Lys 
            180                 185                 190         


Lys Val Ser Thr Asp Ala Ile Ser Met Lys Asn Ser Val Leu Asn Asp 
        195                 200                 205             


Ala Phe Asn His Leu Ile Gln Leu Glu Lys Asn Ser Lys Lys Glu Ile 
    210                 215                 220                 


Pro Gly Arg Tyr Tyr Thr Ser Leu Leu Asn Asp Asn Asn Lys Tyr Thr 
225                 230                 235                 240 


Glu Asn Gly Ile Asn Ile Ser Ile Ser Gly Leu Leu Phe Leu Leu Ser 
                245                 250                 255     


Met Phe Leu Thr Lys Lys Gln Asn Glu Asp Val Arg Ser Arg Ile Phe 
            260                 265                 270         


Gly Phe Lys Gly Thr Ile Glu Ser Asp Lys Gly Ile Ser Lys Ser Asn 
        275                 280                 285             


Asn Ser Phe Arg Asn Met Ala Thr Asn Trp Val Phe Ser Tyr Leu Ser 
    290                 295                 300                 


Phe Lys Gly Met Lys Lys Gln Leu Gly Ser Thr Phe Asn Lys Glu Ser 
305                 310                 315                 320 


Leu Leu Val Gln Ile Val Asp Glu Leu Ser Lys Val Pro His Glu Val 
                325                 330                 335     


Tyr Gln Thr Leu Ser Pro Ser Arg Gln Glu Met Phe Leu Glu Asp Met 
            340                 345                 350         


Asn Glu Tyr Leu Lys Asp Gly Asn Lys Lys His Cys Leu Glu Asp Ser 
        355                 360                 365             


Ile Val Val His Pro Val Ile Lys Lys Arg Tyr Glu Asp Lys Phe Asn 
    370                 375                 380                 


Tyr Phe Ala Ile Arg Tyr Leu Asp Glu Phe Val Asp Phe Pro Ser Leu 
385                 390                 395                 400 


Arg Phe Gln Val Asn Val Gly Asn Tyr Val His Asp Arg Arg Lys Lys 
                405                 410                 415     


Thr Ile Asp Gly Thr Asn Thr Glu Thr Asp Arg Met Val Lys Glu Glu 
            420                 425                 430         


Ile Arg Ala Phe Gly Lys Leu Ser Phe Ile Ser Lys Leu Lys Ala Asp 
        435                 440                 445             


Tyr Phe Ala Lys Asp Leu Pro Ser Asp Ile Ser Trp Glu Met Tyr Pro 
    450                 455                 460                 


Asn Pro Ser Tyr Asn Phe Ser Ala Asn Asn Ile Pro Val Tyr Ile Asp 
465                 470                 475                 480 


Leu Phe Lys Ser Ser Val Ala Gly Ala Ala Asp Val Gly Lys Asp His 
                485                 490                 495     


Lys Gly Tyr Gln Ala Lys Leu Asp Leu Asp Glu Asp Gly Lys Lys Arg 
            500                 505                 510         


Asn Arg Asn Glu Gly Lys Pro Asp Lys Lys Glu Ile Ala Glu Ile Leu 
        515                 520                 525             


Phe Gly Lys Lys Asn Lys Gln Ile Leu Phe Glu Lys Pro Thr Val Leu 
    530                 535                 540                 


Leu Ser Leu Asn Glu Leu Pro Ala Met Leu Tyr Glu Val Leu Ile Glu 
545                 550                 555                 560 


Asn Gly Asp Lys Gln Asp Ile Gly Lys Arg Ile Glu Asp Lys Ile Val 
                565                 570                 575     


Glu Lys Ile Ile Ala His Tyr Asn Leu Leu Asp Gln Tyr Asp Gly Thr 
            580                 585                 590         


Thr Glu Leu Pro Gly Ser Val Ile Pro Arg Lys Leu Arg Met Gly Gly 
        595                 600                 605             


Asn Glu Lys Ser Ile Asn Ile Asp Lys Leu Leu Arg Ala Val Lys Arg 
    610                 615                 620                 


Glu Leu Glu Ile Thr Gln Glu Lys Leu Asp Leu Ile Lys Thr Asn Gln 
625                 630                 635                 640 


Lys Lys Phe Lys Ser Lys Glu Lys Asp Glu Lys Gly Asn Ser Arg Gln 
                645                 650                 655     


His Val Phe Tyr Thr Asn Glu Leu Gly Gln Glu Ala Thr Trp Ile Ala 
            660                 665                 670         


Asn Asp Met Lys Arg Phe Met Pro Lys Glu Val Lys Glu Lys Trp Arg 
        675                 680                 685             


Gly Tyr His His Ser Asn Leu Gln Lys Leu Leu Ala Leu Tyr Asp Gln 
    690                 695                 700                 


Thr Arg Asn Glu Ala Val Lys Cys Ile Thr Cys Phe Trp Asn Phe Asp 
705                 710                 715                 720 


Gln Gln Thr Ser Trp Gly Lys Gly Ile Lys Glu Ala Phe Tyr Lys Ser 
                725                 730                 735     


Thr Phe Glu Glu Phe Tyr Lys Ala Tyr Leu Glu His Arg Met Asp Val 
            740                 745                 750         


Tyr Lys Thr Leu Glu Asn Asn Leu Ile Ala Gly Lys Gly Tyr Ser Lys 
        755                 760                 765             


Leu Phe Asn Lys Glu Lys Lys Lys Ala Phe Ile Leu Phe Asp Glu His 
    770                 775                 780                 


Leu Tyr Thr Ile Pro Asp Ile Asn Thr Gln Lys Glu Arg Leu Lys Ser 
785                 790                 795                 800 


Thr Leu Phe Ile Leu Pro Arg Gly Ile Phe Asp Ser Lys Pro Thr Phe 
                805                 810                 815     


Ile Lys Gly Ile Lys Tyr Glu Glu Asp Pro Ser Cys Phe Ala Asp Trp 
            820                 825                 830         


Tyr Gln Phe Ala Asn Ala Thr Gly Asn Gln Tyr Gln Arg Phe Tyr Asp 
        835                 840                 845             


Leu Pro Arg Ser Tyr Thr Ser Leu Phe Glu Glu Thr Lys Lys Asn Asn 
    850                 855                 860                 


Glu Gly Leu Ile Glu Asn Lys Lys Gly Leu Ser Ala Lys Glu Gln Leu 
865                 870                 875                 880 


Asp Phe Phe Lys Met Arg Gln Asp Leu Lys Ile Lys Lys Ile Lys Thr 
                885                 890                 895     


Gln Asp Leu Phe Leu Phe Met Ile Val Arg Asp Leu Tyr Lys Lys Val 
            900                 905                 910         


Phe Asp His Thr Leu Pro Leu Glu Ile Gly Leu Arg Asp Met Tyr Gln 
        915                 920                 925             


Thr Pro Ala Glu Arg Gln Ala Asn Tyr Asp Leu Ala Val Lys Gln Ser 
    930                 935                 940                 


Gln Arg Thr Glu Gly Asp Asn Ser Asp Asn Leu Tyr Asn Tyr Asn Phe 
945                 950                 955                 960 


Leu Trp Asn Leu Thr Ile Pro Phe Glu Tyr Asp Lys Ile Lys Glu Pro 
                965                 970                 975     


Gln Val Lys Leu Lys Asp Val Gly Lys Phe Tyr Lys Phe Ala Ala Asp 
            980                 985                 990         


Glu Lys Val Gln Thr Ile Leu Ser  Tyr Ser Asp Arg Glu  Trp Ser Lys 
        995                 1000                 1005             


Leu Asp  Leu Glu Lys Glu Leu  Glu Leu Met Pro Thr  Ser Tyr Glu 
    1010                 1015                 1020             


Val Ile  Arg Arg Glu Gln Leu  Leu Arg Asp Ile Gln  Gln Phe Glu 
    1025                 1030                 1035             


Lys Arg  Ile Leu Glu Asn Tyr  Pro Ser Asp Gly Asn  Ala His Pro 
    1040                 1045                 1050             


Ala Asp  Leu Glu Lys Glu Asp  Lys Asp Lys Lys Cys  Phe Pro Asn 
    1055                 1060                 1065             


Phe Asn  Leu Tyr Leu Leu Lys  Gly Ile Ile Ile Lys  Asn Asn Leu 
    1070                 1075                 1080             


Ala Ser  Glu Glu Glu Arg Gln  Trp Phe Glu Gln Val  His Leu Asp 
    1085                 1090                 1095             


Lys Thr  Pro Phe Tyr Pro Glu  Val Glu Thr Lys Ser  Ser Ile Ile 
    1100                 1105                 1110             


Gln Ser  Ala Tyr Leu Leu Leu  Leu Ile Arg Asn Lys  Met Leu His 
    1115                 1120                 1125             


Asn Gln  Leu Pro Ser Lys Gln  Asn Phe Glu Phe Met  Thr Thr Leu 
    1130                 1135                 1140             


Tyr Pro  Phe Glu Gly Tyr Glu  Ser Tyr Ser Thr Tyr  Leu Leu Phe 
    1145                 1150                 1155             


Val Thr  Lys Lys Thr Ile Glu  Cys Leu Ser Ser Ala  Met 
    1160                 1165                 1170     


<210>  1986
<211>  1134
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1986

Met Asn Glu Thr Asp Tyr Leu Ala Lys Arg Leu Glu Tyr Asn Tyr Ala 
1               5                   10                  15      


Ser Ile Glu Asp Lys His Tyr Phe Gly Gly Tyr Phe Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asn Asp Leu Ser Lys Ala Phe Lys Glu Lys Phe Gly Met 
        35                  40                  45              


Lys Pro Lys Ser Cys Ile Leu Asp Phe Phe Thr Gln Asp Lys Ala Ile 
    50                  55                  60                  


Ala Glu Tyr Gln Leu Gly Val Glu Phe Leu Gln Lys Asn Leu Pro Val 
65                  70                  75                  80  


Ile Arg Tyr Leu Tyr Leu Pro Thr Ser His Lys Arg Phe Glu Asn Val 
                85                  90                  95      


Pro Lys Asn Gln Leu Ile Ser Glu Gln Arg Asn Tyr Phe Lys Asn Ser 
            100                 105                 110         


Leu Lys Val Leu Lys Asn Leu Ile Arg Asp Tyr Arg Asn Phe Tyr Thr 
        115                 120                 125             


His His Phe His Lys Pro Ile Pro Val Phe Pro Glu Thr Tyr Lys Leu 
    130                 135                 140                 


Leu Asp Asp Leu Phe Leu Ala Val Ala Asn Asp Val Lys Lys His Arg 
145                 150                 155                 160 


Met Lys Thr Asp Ala Ser Lys Gln Leu Leu Lys Lys Gly Leu Ile Glu 
                165                 170                 175     


Glu Leu Ala Gln Leu Glu Lys Leu Lys Leu Glu Asp Leu Lys Lys Leu 
            180                 185                 190         


Lys Arg Glu Gly Lys Lys Val Asn Leu Asn Asp Lys Glu Ala Ile Thr 
        195                 200                 205             


Asn Ala Ile Leu Asn Asp Ser Phe Ser His Leu Leu Pro Lys Glu Asn 
    210                 215                 220                 


Thr Ile Ser Lys Tyr Tyr Ser Ala Val Pro Thr Glu Asp Ile Asp Thr 
225                 230                 235                 240 


Glu Asn Gly Val Thr Ile Ser Glu Ser Gly Ile Ile Phe Leu Leu Gly 
                245                 250                 255     


Leu Phe Leu Thr Lys Lys Gln Ser Glu Asp Leu Arg Ser Arg Val Lys 
            260                 265                 270         


Gly Phe Lys Ala Lys Leu Ile Val Asn Pro Glu Asn Pro Ile Asn Lys 
        275                 280                 285             


Lys Asn Asn Ser Leu Lys Tyr Met Ala Thr His Trp Val Phe Gly Tyr 
    290                 295                 300                 


Leu Gly Phe Lys Gly Leu Lys Asn Arg Phe Thr Thr Thr Phe Thr Lys 
305                 310                 315                 320 


Asp Thr Leu Leu Ala Gln Ile Val Asp Glu Leu Ser Lys Val Pro Asp 
                325                 330                 335     


Glu Leu Tyr Gln Val Leu Pro Glu Glu Leu Lys Asn Glu Phe Leu Glu 
            340                 345                 350         


Asp Met Asn Glu Tyr Leu Lys Glu Glu Asn Ser Glu Ser Leu Asp Lys 
        355                 360                 365             


Ala Thr Val Ile His Pro Val Ile Arg Lys Arg Tyr Glu Asn Lys Phe 
    370                 375                 380                 


Ala Tyr Phe Ala Leu Arg Phe Leu Asp Glu Phe Val Asp Phe Pro Thr 
385                 390                 395                 400 


Leu Arg Phe Gln Leu His Leu Gly Asn Tyr Val His Asp Lys Arg Glu 
                405                 410                 415     


Lys Pro Ile Glu Gly Thr Lys Tyr Val Thr Glu Arg Ile Val Lys Glu 
            420                 425                 430         


Lys Ile Lys Ala Phe Ala Lys Leu Ser Glu Ala Ala Gln Leu Lys Gln 
        435                 440                 445             


Lys Tyr Phe Glu Glu Lys Glu Asn His Gln Ser Ile Gly Leu Gln Leu 
    450                 455                 460                 


Tyr Pro Asn Pro Ser Tyr Asn Phe Val Gly Asn Asn Ile Pro Ile His 
465                 470                 475                 480 


Leu Asn Leu Asn Glu His Phe Phe Pro Lys Glu Val Lys Ile Val Ala 
                485                 490                 495     


Gly Arg Leu Lys Lys Arg Asn Ser Ser Tyr Lys Ser Asp His Pro Glu 
            500                 505                 510         


Glu Tyr Lys Val Arg Thr Asp Asn Lys Ile Lys Pro Asp Ala Ile Leu 
        515                 520                 525             


Gln Asp Leu Gly Lys Pro Glu Lys Leu Ala Pro Val Ala Met Leu Ser 
    530                 535                 540                 


Leu Asn Glu Leu Pro Ala Leu Leu His Leu Val Leu Thr Lys Lys Thr 
545                 550                 555                 560 


Pro Glu Glu Ile Glu Ile Ile Ile Ala Gln Lys Ile Ala Glu Arg Tyr 
                565                 570                 575     


Asn Val Leu Thr Asn Tyr Lys Ala Gly Asp Asp Ile Ser Lys Gly Gln 
            580                 585                 590         


Ile Thr Lys Asn Leu Leu Lys Ala Lys Gln Lys Lys Glu Val Asn Leu 
        595                 600                 605             


Asp Lys Leu Gln Leu Ala Ile Glu Lys Glu Ile Ala Val Thr Asn Asp 
    610                 615                 620                 


Lys Leu Gln Thr Ile Ala Leu His Ile Lys Glu Arg Asn Asp Pro Lys 
625                 630                 635                 640 


Gln Lys Arg Lys Tyr Val Phe Thr Asn Lys Glu Ile Gly Leu Gln Val 
                645                 650                 655     


Thr Trp Leu Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Gly Ser Arg 
            660                 665                 670         


Gln Asn Trp Arg Gly Gln His His Ser Gln Leu Gln Lys Ser Leu Ala 
        675                 680                 685             


Phe Tyr Asp Ile Gln Pro Lys Glu Pro Leu Ser Leu Leu Glu Glu Val 
    690                 695                 700                 


Trp Asp Phe Lys Asn Glu Ala Tyr Leu Trp Asn Asn Gly Ile Arg Arg 
705                 710                 715                 720 


Ser Phe Asp Lys Arg Asp Phe Ile Ser Phe Tyr Thr Ser Tyr Leu Asn 
                725                 730                 735     


Asn Arg Lys Glu Thr Phe Gln Arg Phe Lys Asp Gln Leu Asn Gly Ile 
            740                 745                 750         


Arg Ser Asn Lys Lys Ile Leu Asp Lys Phe Ile Lys Gln Gln His Leu 
        755                 760                 765             


Trp Asn Leu Phe His Lys Arg Leu Tyr Val Ile Asp Thr Ile Glu Glu 
    770                 775                 780                 


Gln Val Glu Lys Leu Leu Val Lys Pro Met Gln Phe Pro Lys Gly Val 
785                 790                 795                 800 


Phe Asp His Lys Pro Thr Tyr Ile Lys Gly Lys Ser Ile Gln Glu Asn 
                805                 810                 815     


Pro Glu Cys Phe Ala Asp Trp Tyr Val Ala Trp Asn Gln His Thr Asp 
            820                 825                 830         


Tyr Gln Lys Phe Tyr Ser Trp Asp Arg Asp Tyr Lys Ser Ala Tyr Leu 
        835                 840                 845             


Ser Gly Glu Gln Glu Lys Thr Glu Lys Arg Phe Ile Arg Val Gln Gly 
    850                 855                 860                 


Ser Lys Ile Asn Lys Val Lys Gln Gln Asp Val Leu Leu Ala Lys Met 
865                 870                 875                 880 


Ala Ser Ile Ile Phe Asn Glu Leu Tyr Leu Pro Glu Asp Ala Glu His 
                885                 890                 895     


Leu Asp Leu Asn Leu Ser Asp Ile Tyr Lys Thr Gln Thr Glu Arg Lys 
            900                 905                 910         


Ala Glu Ile Glu Ala Ala Leu Ile Gln Ser His Lys Thr Thr Gly Asp 
        915                 920                 925             


Asn Ser Ala Asn Ile Ile Lys Ser Thr Ser Ala Trp Thr Leu Thr Val 
    930                 935                 940                 


Pro Tyr Cys Ser Lys Asn Ile Tyr Glu Pro Gln Val Lys Leu Lys Glu 
945                 950                 955                 960 


Leu Gly Lys Phe Lys Lys Phe Ile Ala Ser Gln Lys Val Gln Thr Leu 
                965                 970                 975     


Phe Glu Tyr Lys Pro Gln Lys Ile Trp Asn Lys Thr Glu Leu Glu Glu 
            980                 985                 990         


Val Leu Glu Leu Lys Ala Asn Ser  Tyr Glu Val Ile Arg  Arg Asp Tyr 
        995                 1000                 1005             


Leu Leu  Lys Ser Ile Gln Glu  Phe Glu Lys Tyr Met  Ile Lys Lys 
    1010                 1015                 1020             


Leu Pro  Thr Leu Ile Asp Thr  Asn Glu His Pro Asn  Phe Asn Lys 
    1025                 1030                 1035             


Tyr Leu  Thr Thr Phe Leu Lys  Ser Leu Glu Leu Val  Ser Glu Glu 
    1040                 1045                 1050             


Asp Ala  Lys Trp Leu Ile Ser  Lys Lys Asp Phe Asp  Thr Thr Pro 
    1055                 1060                 1065             


Ile Asp  Glu Leu Lys Lys Gln  Ser Lys Ile Met Glu  Lys Ala Phe 
    1070                 1075                 1080             


Leu Leu  Val Met Ile Arg Asn  Lys Phe Ser His Asn  Gln Leu Pro 
    1085                 1090                 1095             


Arg Lys  Ile Tyr Tyr Asp Glu  Ile Tyr Lys Asn Val  Pro Asn Ala 
    1100                 1105                 1110             


Val Ser  Ile Asn Phe Asn Glu  Leu Phe Leu Glu Tyr  Thr Asn Gln 
    1115                 1120                 1125             


Thr Ile  Leu Glu Phe Lys 
    1130                 


<210>  1987
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1987

Met Asn Thr His Gln Glu Glu Leu Gln Ser Trp Ile Thr Arg Lys Arg 
1               5                   10                  15      


Leu Pro Asp Thr Glu Met Lys Lys Tyr Trp Ala Ala Tyr Met Asn Leu 
            20                  25                  30          


Ala Arg Leu Asn Phe Phe Lys Thr Leu Met Phe Ile Ser Asn Ser Ile 
        35                  40                  45              


Gly Asp Leu Lys Pro Ala Lys Asp Asn Asn Gly Lys Gly Asn Thr Glu 
    50                  55                  60                  


Val Asn Met His Asn Met Gly Ile Leu Thr Ala Leu Leu Gly Pro Glu 
65                  70                  75                  80  


Asp Glu Glu Lys Ala Arg Leu Leu Ile Phe Lys His Phe Pro Phe Leu 
                85                  90                  95      


Arg Thr Phe Cys Ile Glu Lys Glu Leu Ser Leu Ser Lys Gln Arg Thr 
            100                 105                 110         


Ile Leu Ile Asp Met Ala Cys Ile Ile Gly Arg Tyr Arg Asn Met Tyr 
        115                 120                 125             


Ser His Ser Ile Phe Ile Ser Asp Asp Asn Glu Lys Val Leu Glu Ser 
    130                 135                 140                 


Glu Lys Arg Cys Ser Glu Tyr Leu Gln Ser Ile Leu Thr Val Ser Thr 
145                 150                 155                 160 


Arg Ile Ile Lys Glu Arg Tyr Arg Ser Asn Lys Asn Asp Ala Gln Arg 
                165                 170                 175     


Gly Met Ile Asp Asp Lys Ser Leu Lys Phe Ile Ser Glu Asn Lys Val 
            180                 185                 190         


Lys Phe Val Tyr Asp Glu Asn Gly Lys Arg Ile Thr Ala Pro Asn Lys 
        195                 200                 205             


Lys Tyr Tyr Leu Ser Thr Ile Asp Lys Asp Asn Thr His Leu Ser Tyr 
    210                 215                 220                 


Phe Gly Lys Leu Met Leu Thr Cys Ile Leu Leu Glu Lys Lys Tyr Ala 
225                 230                 235                 240 


Thr Asp Phe Leu Thr Gln Cys His Phe Leu Asp Ala Phe Asn Asp Ser 
                245                 250                 255     


Glu Val Ala Pro Lys Leu Ser Glu Arg Arg Leu Met Leu Glu Val Met 
            260                 265                 270         


Thr Ala Leu Arg Ile Arg Leu Ala Glu Lys Lys Leu Ser Asn Glu Lys 
        275                 280                 285             


Ser Glu Val Gln Ile Ser Leu Asp Ile Leu Asn Glu Leu Lys Lys Cys 
    290                 295                 300                 


Pro Phe Glu Leu Tyr Glu Leu Leu Gly Ser Glu Asp Lys Arg Leu Phe 
305                 310                 315                 320 


Thr Ile Val Ala Asp Thr Gly Glu Thr Ile Leu Leu Arg Arg His Glu 
                325                 330                 335     


Asp Arg Phe Pro Gln Leu Ala Leu Ser Trp Ile Asp Ser Ser Lys Ala 
            340                 345                 350         


Phe Asp His Leu Arg Phe Gln Val Asn Ala Gly Lys Leu Arg Tyr Leu 
        355                 360                 365             


Phe Arg Asp Asn Lys His Cys Ile Asp Gly Gln Thr Arg Met Arg Val 
    370                 375                 380                 


Leu Glu Glu Pro Leu Asn Gly Tyr Arg Arg Leu Met Glu Phe Glu Glu 
385                 390                 395                 400 


Glu Arg Ile Gln Lys Gln Ser Gly Glu Ile Arg Ser Leu Trp Pro Gly 
                405                 410                 415     


Leu Asp Ile Leu Asn Lys Asp Glu Thr Pro Arg Asn Asp Ala Ser Val 
            420                 425                 430         


Leu Pro Tyr Ile Ser Asp Tyr Arg Val Arg Tyr Leu Phe Asp Gly Asp 
        435                 440                 445             


Asn Ile Gly Ile Ser Ile Gly Asp Phe Thr Pro Ser Ile Thr Lys Thr 
    450                 455                 460                 


Asp Glu Thr Lys Tyr Arg Val Thr Gly Lys Thr Ala Asp Cys Cys Leu 
465                 470                 475                 480 


Ser Lys Tyr Glu Leu Leu Gly Leu Leu Phe Tyr His Leu Leu Thr Leu 
                485                 490                 495     


Arg His Gly Asp Asn Lys Arg Ser Thr Lys Asn Ala Glu Asp Ile Ile 
            500                 505                 510         


Ile Asp Ala Ile Lys Arg Tyr Lys Arg Leu Phe Ser Asp Val Lys Glu 
        515                 520                 525             


Gly Ile Leu Lys Pro Ile Lys Glu Glu Asn Ala Asn Gln Leu Gly Asn 
    530                 535                 540                 


Arg Ile Trp Asn Ser Tyr Gly Ile Asn Ile Lys Asp Ile Pro Asp Lys 
545                 550                 555                 560 


Ile Ile Asp Tyr Leu Leu Val Arg Glu Cys Asn Glu Asp Glu Lys Phe 
                565                 570                 575     


Thr Ala Trp Lys Asn Gly Phe Ile Ser Glu Met Leu Gln Ser Thr Lys 
            580                 585                 590         


Asn Arg Ile Lys Arg Phe Glu Lys Asp Ser Glu Ala Val Ile Ser Ser 
        595                 600                 605             


Asp Asn Lys Pro Gly Lys Lys Asn His Val Ser Leu Lys Pro Gly Ala 
    610                 615                 620                 


Tyr Ala Ser Phe Ile Ala Asn Asp Ile Val Phe Phe Gln Glu Cys Gly 
625                 630                 635                 640 


Ala Thr Glu Lys Met Thr Gly Leu Asn Phe Lys Val Met Gln Ser Arg 
                645                 650                 655     


Leu Ala Thr Phe Thr Lys Asp Gly Ser Thr Ser Phe Asn Ile Leu Leu 
            660                 665                 670         


Gln Thr Leu Lys Asn Ala His Leu Val Ser Thr Thr Tyr Gly Lys Gly 
        675                 680                 685             


Asp His Pro Phe Leu Tyr Arg Val Ile Lys Gln Gln Pro Ser Asp Ile 
    690                 695                 700                 


Val Gln Phe Tyr Lys Ile Tyr Leu Asn Glu Lys Val Leu Tyr Leu Gln 
705                 710                 715                 720 


Ser Asp Ile Pro Asp Asn Ala Ile Phe Leu His Gly Glu Arg Lys Arg 
                725                 730                 735     


Trp Glu Asn Arg Asn Glu Gln Tyr Tyr Arg Asp Leu Ala Glu Arg Tyr 
            740                 745                 750         


Leu Gln Arg Pro Ile Gln Leu Pro Arg Gln Leu Phe Glu Ser His Ile 
        755                 760                 765             


Arg Gln Leu Leu Leu Ser Asp Cys Ile Lys Gly Glu Arg Gly Asn Asp 
    770                 775                 780                 


Leu Lys Glu Ala Ile Asn Ser Ala Ala Ser Gln Gly Arg Cys Asn Thr 
785                 790                 795                 800 


Thr Tyr Met Ile Met Glu Tyr Phe Ala Asp Tyr Leu Cys Asp Gly Thr 
                805                 810                 815     


Gln Phe Phe Tyr Gly Leu Phe Asp Gly Asp Leu Ser His Glu Tyr Asn 
            820                 825                 830         


Tyr Arg Phe Tyr Ser Leu Ile Ser Asn Asn Ile Glu Asn Ser Lys Lys 
        835                 840                 845             


Leu Val Leu Thr Leu Lys Lys Gly Asn Asn Ser Lys Glu Ser Pro Phe 
    850                 855                 860                 


Ile Ser Ala Leu Glu Arg Gly Ile His Trp Ser Lys Met Asn Pro Leu 
865                 870                 875                 880 


Met Lys Lys Gly Leu Lys Asn Asp Ser Ser Glu Gly Asp Phe Val His 
                885                 890                 895     


Ala Ala Lys Arg Ala Tyr Lys Glu Met Thr Glu Thr Glu Arg Met Phe 
            900                 905                 910         


Arg Arg Tyr Ala Val Gln Asp Glu Val Leu Phe Leu Ala Ala Lys Ile 
        915                 920                 925             


Thr Ile Arg Arg Ala Leu Gly Leu Ser Glu Gln Tyr Asn Cys Leu Leu 
    930                 935                 940                 


Gly Asp Ile Lys Pro Gln Gly Gly Ser Leu Leu Glu Gln Thr Ile Pro 
945                 950                 955                 960 


Ser Ile Thr Thr Lys His Thr Ile Asn Thr Gly Asn Lys Lys Gln Lys 
                965                 970                 975     


Pro Lys Gln Val Gln Ile Leu Gln Lys Asn Val Lys Leu Lys Asp Phe 
            980                 985                 990         


Gly Lys Val Phe Lys Leu Leu Asn  Asp Arg Arg Ile Phe  Asp Leu Leu 
        995                 1000                 1005             


Phe Asn  Lys Gly Asn Glu Ala  Val Ser Met Thr Asp  Leu Cys Glu 
    1010                 1015                 1020             


Glu Leu  Glu Arg Tyr Asp Arg  His Arg Val Asp Val  Phe Asp Ser 
    1025                 1030                 1035             


Val Leu  Lys Tyr Glu Ser Lys  Ile Thr Lys Gly Tyr  Thr Asn Lys 
    1040                 1045                 1050             


Glu Leu  Met Asn Glu Ser Gly  Gln Ile Asp Phe Lys  Ala Ile Gln 
    1055                 1060                 1065             


Ala Phe  Asp Lys Gln Asn Thr  Thr Ala Asp Lys Glu  Asp Leu Arg 
    1070                 1075                 1080             


Leu Ile  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Gln Tyr Asn 
    1085                 1090                 1095             


Asn Glu  Pro Ile Leu Phe Asp  Lys Asp Ile Pro Glu  Ile Ala Asp 
    1100                 1105                 1110             


Glu Ile  Ser Ile Ile Ala Lys  Asp Ile Glu Glu Asn  Thr Lys 
    1115                 1120                 1125         


<210>  1988
<211>  1134
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1988

Met Asn Glu Thr Asp Tyr Leu Ala Lys Arg Leu Glu Tyr Asn Tyr Ala 
1               5                   10                  15      


Ser Ile Glu Asp Lys His Tyr Phe Gly Gly Tyr Phe Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asn Asp Leu Ser Lys Ala Phe Lys Glu Lys Phe Gly Met 
        35                  40                  45              


Lys Pro Lys Ser Cys Ile Leu Asp Phe Phe Thr Gln Asp Lys Ala Ile 
    50                  55                  60                  


Ala Glu Tyr Gln Leu Gly Val Glu Phe Leu Gln Lys Asn Leu Pro Val 
65                  70                  75                  80  


Ile Arg Tyr Leu Tyr Leu Pro Thr Ser His Lys Arg Phe Glu Asn Val 
                85                  90                  95      


Pro Lys Asn Gln Leu Ile Ser Glu Gln Arg Asn Tyr Phe Lys Asn Ser 
            100                 105                 110         


Leu Lys Val Leu Lys Asn Leu Ile Arg Asp Tyr Arg Asn Phe Tyr Thr 
        115                 120                 125             


His His Phe His Lys Pro Ile Pro Val Phe Pro Glu Thr Tyr Lys Leu 
    130                 135                 140                 


Leu Asp Asp Leu Phe Leu Ala Val Ala Asn Asp Val Lys Lys His Arg 
145                 150                 155                 160 


Met Lys Thr Asp Ala Ser Lys Gln Leu Leu Lys Lys Gly Leu Ile Glu 
                165                 170                 175     


Glu Leu Ala Gln Leu Glu Lys Leu Lys Leu Glu Asp Leu Lys Lys Leu 
            180                 185                 190         


Lys Arg Glu Gly Lys Lys Val Asn Leu Asn Asp Lys Glu Ala Ile Thr 
        195                 200                 205             


Asn Ala Ile Leu Asn Asp Ser Phe Ser His Leu Leu Pro Lys Glu Asn 
    210                 215                 220                 


Thr Ile Ser Lys Tyr Tyr Ser Ala Val Pro Thr Glu Asp Ile Asp Thr 
225                 230                 235                 240 


Glu Asn Gly Val Thr Ile Ser Glu Ser Gly Ile Ile Phe Leu Leu Gly 
                245                 250                 255     


Leu Phe Leu Thr Lys Lys Gln Ser Glu Asp Leu Arg Ser Arg Val Lys 
            260                 265                 270         


Gly Phe Lys Ala Lys Leu Ile Val Asn Pro Glu Asn Pro Ile Asn Lys 
        275                 280                 285             


Lys Asn Asn Ser Leu Lys Tyr Met Ala Thr His Trp Val Phe Gly Tyr 
    290                 295                 300                 


Leu Gly Phe Lys Gly Leu Lys Asn Arg Phe Thr Thr Thr Phe Thr Lys 
305                 310                 315                 320 


Asp Thr Leu Leu Ala Gln Ile Val Asp Glu Leu Ser Lys Val Pro Asp 
                325                 330                 335     


Glu Leu Tyr Gln Val Leu Pro Glu Glu Leu Lys Asn Glu Phe Leu Glu 
            340                 345                 350         


Asp Met Asn Glu Tyr Leu Lys Glu Glu Asn Ser Glu Ser Leu Asp Lys 
        355                 360                 365             


Ala Thr Val Ile His Pro Val Ile Arg Lys Arg Tyr Glu Asn Lys Phe 
    370                 375                 380                 


Ala Tyr Phe Ala Leu Arg Phe Leu Asp Glu Phe Val Asp Phe Pro Thr 
385                 390                 395                 400 


Leu Arg Phe Gln Leu His Leu Gly Asn Tyr Val His Asp Lys Arg Glu 
                405                 410                 415     


Lys Pro Ile Glu Gly Thr Lys Tyr Val Thr Glu Arg Ile Val Lys Glu 
            420                 425                 430         


Lys Ile Lys Ala Phe Ala Lys Leu Ser Glu Ala Ala Gln Leu Lys Gln 
        435                 440                 445             


Lys Tyr Phe Glu Glu Lys Glu Asn His Gln Ser Ile Gly Leu Gln Leu 
    450                 455                 460                 


Tyr Pro Asn Pro Ser Tyr Asn Phe Val Gly Asn Asn Ile Pro Ile His 
465                 470                 475                 480 


Leu Asn Leu Asn Glu His Phe Phe Pro Lys Glu Val Lys Ile Val Ala 
                485                 490                 495     


Gly Arg Leu Lys Lys Arg Asn Ser Ser Tyr Lys Ser Asp His Pro Glu 
            500                 505                 510         


Glu Tyr Lys Val Arg Thr Asp Asn Lys Ile Lys Pro Asp Ala Ile Leu 
        515                 520                 525             


Gln Asp Leu Gly Lys Pro Glu Lys Leu Ala Pro Val Ala Met Leu Ser 
    530                 535                 540                 


Leu Asn Glu Leu Pro Ala Leu Leu His Leu Val Leu Thr Lys Lys Thr 
545                 550                 555                 560 


Pro Glu Glu Ile Glu Ile Ile Ile Ala Gln Lys Ile Ala Glu Arg Tyr 
                565                 570                 575     


Asn Val Leu Thr Asn Tyr Lys Ala Gly Asp Asp Ile Ser Lys Gly Gln 
            580                 585                 590         


Ile Thr Lys Asn Leu Leu Lys Ala Lys Gln Lys Lys Glu Val Asn Leu 
        595                 600                 605             


Asp Lys Leu Gln Leu Ala Ile Glu Lys Glu Ile Ala Val Thr Asn Asp 
    610                 615                 620                 


Lys Leu Gln Thr Ile Ala Leu His Ile Lys Glu Arg Asn Asp Pro Lys 
625                 630                 635                 640 


Gln Lys Arg Lys Tyr Val Phe Thr Asn Lys Glu Ile Gly Leu Gln Val 
                645                 650                 655     


Thr Trp Leu Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Gly Ser Arg 
            660                 665                 670         


Gln Asn Trp Arg Gly Gln His His Ser Gln Leu Gln Lys Ser Leu Ala 
        675                 680                 685             


Phe Tyr Asp Ile Gln Pro Lys Glu Pro Leu Ser Leu Leu Glu Glu Val 
    690                 695                 700                 


Trp Asp Phe Lys Asn Glu Ala Tyr Leu Trp Asn Asn Gly Ile Arg Arg 
705                 710                 715                 720 


Ser Phe Asp Lys Arg Asp Phe Ile Ser Phe Tyr Thr Ser Tyr Leu Asn 
                725                 730                 735     


Asn Arg Lys Glu Thr Phe Gln Arg Phe Lys Asp Gln Leu Asn Gly Ile 
            740                 745                 750         


Arg Ser Asn Lys Lys Ile Leu Asp Lys Phe Ile Lys Gln Gln His Leu 
        755                 760                 765             


Trp Asn Leu Phe His Lys Arg Leu Tyr Val Ile Asp Thr Ile Glu Glu 
    770                 775                 780                 


Gln Val Glu Lys Leu Leu Val Lys Pro Met Gln Phe Pro Lys Gly Val 
785                 790                 795                 800 


Phe Asp His Lys Pro Thr Tyr Ile Lys Gly Lys Ser Ile Gln Glu Asn 
                805                 810                 815     


Pro Glu Cys Phe Ala Asp Trp Tyr Val Ala Trp Asn Gln His Thr Asp 
            820                 825                 830         


Tyr Gln Lys Phe Tyr Ser Trp Asp Arg Asp Tyr Lys Ser Ala Tyr Leu 
        835                 840                 845             


Ser Gly Glu Gln Glu Lys Thr Glu Lys Arg Phe Ile Arg Val Gln Gly 
    850                 855                 860                 


Ser Lys Ile Asn Lys Val Lys Gln Gln Asp Val Leu Leu Ala Lys Met 
865                 870                 875                 880 


Ala Ser Ile Ile Phe Asn Glu Leu Tyr Leu Pro Glu Asp Ala Glu His 
                885                 890                 895     


Leu Asp Leu Asn Leu Ser Asp Ile Tyr Lys Thr Gln Thr Glu Arg Lys 
            900                 905                 910         


Ala Glu Ile Glu Ala Ala Leu Ile Gln Ser His Lys Thr Thr Gly Asp 
        915                 920                 925             


Asn Ser Ala Asn Ile Ile Lys Ser Thr Ser Ala Trp Thr Leu Thr Val 
    930                 935                 940                 


Pro Tyr Cys Ser Lys Asn Ile Tyr Glu Pro Gln Val Lys Leu Lys Glu 
945                 950                 955                 960 


Leu Gly Lys Phe Lys Lys Phe Ile Ala Ser Gln Lys Val Gln Thr Leu 
                965                 970                 975     


Phe Glu Tyr Lys Pro Gln Lys Ile Trp Asn Lys Thr Glu Leu Glu Glu 
            980                 985                 990         


Val Leu Glu Leu Lys Ala Asn Ser  Tyr Glu Val Ile Arg  Arg Asp Tyr 
        995                 1000                 1005             


Leu Leu  Lys Ser Ile Gln Glu  Phe Glu Lys Tyr Met  Ile Lys Lys 
    1010                 1015                 1020             


Leu Pro  Thr Leu Ile Asp Thr  Asn Glu His Pro Asn  Phe Asn Lys 
    1025                 1030                 1035             


Tyr Leu  Thr Thr Phe Leu Lys  Ser Leu Glu Leu Val  Ser Glu Glu 
    1040                 1045                 1050             


Asp Ala  Lys Trp Leu Ile Ser  Lys Lys Asp Phe Asp  Thr Thr Pro 
    1055                 1060                 1065             


Ile Asp  Glu Leu Lys Lys Gln  Ser Lys Ile Met Glu  Lys Ala Phe 
    1070                 1075                 1080             


Leu Leu  Val Met Ile Arg Asn  Lys Phe Ser His Asn  Gln Leu Pro 
    1085                 1090                 1095             


Arg Lys  Ile Tyr Tyr Asp Glu  Ile Tyr Lys Asn Val  Pro Asn Ala 
    1100                 1105                 1110             


Val Ser  Ile Asn Phe Asn Glu  Leu Phe Leu Glu Tyr  Thr Asn Gln 
    1115                 1120                 1125             


Thr Ile  Leu Glu Phe Lys 
    1130                 


<210>  1989
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1989

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Thr Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1990
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1990

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1991
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1991

Leu Gln Lys Gln Asp Lys Leu Phe Val Asp Arg Lys Lys Asn Ala Ile 
1               5                   10                  15      


Phe Ala Phe Pro Lys Tyr Ile Thr Ile Met Glu Asn Lys Glu Lys Pro 
            20                  25                  30          


Glu Pro Ile Tyr Tyr Glu Leu Thr Asp Lys His Phe Trp Ala Ala Phe 
        35                  40                  45              


Leu Asn Leu Ala Arg His Asn Val Tyr Thr Thr Ile Asn His Ile Asn 
    50                  55                  60                  


Arg Arg Leu Glu Ile Ala Glu Leu Lys Asp Asp Gly Tyr Met Met Gly 
65                  70                  75                  80  


Ile Lys Gly Ser Trp Asn Glu Gln Ala Lys Lys Leu Asp Lys Lys Val 
                85                  90                  95      


Arg Leu Arg Asp Leu Ile Met Lys His Phe Pro Phe Leu Glu Ala Ala 
            100                 105                 110         


Ala Tyr Glu Ile Thr Asn Ser Lys Ser Ser Asn Asn Lys Glu Gln Arg 
        115                 120                 125             


Glu Lys Glu Gln Ser Glu Ala Leu Ser Leu Asn Asn Leu Lys Asn Val 
    130                 135                 140                 


Leu Phe Ile Phe Leu Glu Lys Leu Gln Val Leu Arg Asn Tyr Tyr Ser 
145                 150                 155                 160 


His Tyr Lys Tyr Ser Glu Glu Ser Pro Lys Pro Ile Phe Glu Thr Ser 
                165                 170                 175     


Leu Leu Lys Asn Met Tyr Lys Val Phe Asp Ala Asn Val Arg Leu Val 
            180                 185                 190         


Lys Arg Asp Tyr Met His His Glu Asn Ile Asp Met Gln Arg Asp Phe 
        195                 200                 205             


Thr His Leu Asn Arg Lys Lys Gln Val Gly Arg Thr Lys Asn Ile Ile 
    210                 215                 220                 


Asp Ser Pro Asn Phe His Tyr His Phe Ala Asp Lys Glu Gly Asn Met 
225                 230                 235                 240 


Thr Ile Ala Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Asp Lys Lys 
                245                 250                 255     


Asp Ala Ile Trp Met Gln Lys Lys Leu Lys Gly Phe Lys Asp Gly Arg 
            260                 265                 270         


Asn Leu Arg Glu Gln Met Thr Asn Glu Val Phe Cys Arg Ser Arg Ile 
        275                 280                 285             


Ser Leu Pro Lys Leu Lys Leu Glu Asn Val Gln Thr Lys Asp Trp Met 
    290                 295                 300                 


Gln Leu Asp Met Leu Asn Glu Leu Val Arg Cys Pro Lys Ser Leu Tyr 
305                 310                 315                 320 


Glu Arg Leu Arg Glu Lys Asp Arg Glu Ser Phe Lys Val Pro Phe Asp 
                325                 330                 335     


Ile Phe Ser Asp Asp Tyr Asp Ala Glu Glu Glu Pro Phe Lys Asn Thr 
            340                 345                 350         


Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe 
        355                 360                 365             


Asp Leu Asn Glu Ile Phe Glu Gln Leu Arg Phe Gln Ile Asp Leu Gly 
    370                 375                 380                 


Thr Tyr His Phe Ser Ile Tyr Asn Lys Arg Ile Gly Asp Glu Asp Glu 
385                 390                 395                 400 


Val Arg His Leu Thr His His Leu Tyr Gly Phe Ala Arg Ile Gln Asp 
                405                 410                 415     


Phe Ala Pro Gln Asn Gln Pro Glu Glu Trp Arg Lys Leu Val Lys Asp 
            420                 425                 430         


Leu Asp His Phe Glu Thr Ser Gln Glu Pro Tyr Ile Ser Lys Thr Ala 
        435                 440                 445             


Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Lys Phe Cys Ser 
    450                 455                 460                 


Thr His Asn Asn Leu Phe Pro Ser Leu Lys Arg Glu Lys Thr Cys Asn 
465                 470                 475                 480 


Gly Arg Ser Lys Phe Asn Leu Gly Thr Gln Phe Thr Ala Glu Ala Phe 
                485                 490                 495     


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu 
            500                 505                 510         


Thr Lys Asp His Pro Lys Gly Glu Gly Val Asn Lys Ile Glu Lys Ile 
        515                 520                 525             


Ile Arg Thr Glu Ile Ser Asn Ile Tyr Asp Ile Tyr Asp Ala Phe Ala 
    530                 535                 540                 


Asn Gly Glu Ile Asn Ser Ile Ala Asp Leu Thr Cys Arg Leu Gln Lys 
545                 550                 555                 560 


Thr Asn Ile Leu Gln Gly His Leu Pro Lys Gln Met Ile Ser Ile Leu 
                565                 570                 575     


Glu Gly Arg Gln Lys Asp Met Glu Lys Glu Ala Glu Arg Lys Ile Gly 
            580                 585                 590         


Glu Met Ile Asp Asp Thr Gln Arg Arg Leu Asp Leu Leu Cys Lys Gln 
        595                 600                 605             


Thr Asn Gln Lys Ile Arg Ile Gly Lys Arg Asn Ala Gly Leu Leu Lys 
    610                 615                 620                 


Ser Gly Lys Ile Ala Asp Trp Leu Val Asn Asp Met Met Arg Phe Gln 
625                 630                 635                 640 


Pro Val Gln Lys Asp Gln Asn Asn Ile Pro Ile Asn Asn Ser Lys Ala 
                645                 650                 655     


Asn Ser Thr Glu Tyr Arg Met Leu Gln Arg Ala Leu Ala Leu Phe Gly 
            660                 665                 670         


Ser Glu Asn Phe Arg Leu Lys Ala Tyr Phe Asn Gln Met Asn Leu Val 
        675                 680                 685             


Gly Asn Asp Asn Pro His Pro Phe Leu Ala Glu Thr Gln Trp Glu His 
    690                 695                 700                 


Gln Thr Asn Ile Leu Ser Phe Tyr Arg Asn Tyr Leu Glu Ala Arg Lys 
705                 710                 715                 720 


Lys Tyr Leu Lys Gly Leu Lys Pro Gln Asn Trp Lys Gln Tyr Gln His 
                725                 730                 735     


Phe Leu Ile Leu Lys Val Gln Lys Thr Asn Arg Asn Thr Leu Val Thr 
            740                 745                 750         


Gly Trp Lys Asn Ser Phe Asn Leu Pro Arg Gly Ile Phe Thr Gln Pro 
        755                 760                 765             


Ile Arg Glu Trp Phe Glu Lys His Asn Asn Ser Lys Arg Ile Tyr Asp 
    770                 775                 780                 


Gln Ile Leu Ser Phe Asp Arg Val Gly Phe Val Ala Lys Ala Ile Pro 
785                 790                 795                 800 


Leu Tyr Phe Thr Glu Glu Tyr Lys Asp Asn Val Gln Pro Phe Tyr Asp 
                805                 810                 815     


Tyr Pro Phe Asn Ile Gly Asn Lys Leu Lys Pro Gln Lys Gly Gln Phe 
            820                 825                 830         


Leu Asp Lys Lys Glu Arg Val Glu Leu Trp Gln Lys Asn Lys Glu Leu 
        835                 840                 845             


Phe Lys Asn Tyr Pro Ser Glu Lys Lys Lys Thr Asp Leu Ala Tyr Leu 
    850                 855                 860                 


Asp Phe Leu Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys 
865                 870                 875                 880 


Asn Gln Asp Ile Val Thr Trp Leu Met Phe Lys Glu Leu Phe Lys Thr 
                885                 890                 895     


Thr Thr Val Glu Glu Leu Lys Ile Gly Glu Ile His Leu Arg Asp Ile 
            900                 905                 910         


Asp Thr Asn Thr Ala Asn Glu Glu Ser Asn Asn Ile Leu Asn Arg Ile 
        915                 920                 925             


Met Pro Met Lys Leu Pro Val Lys Thr Tyr Glu Thr Asp Asn Lys Gly 
    930                 935                 940                 


Asn Ile Leu Lys Glu Arg Pro Leu Ala Thr Phe Tyr Ile Glu Glu Thr 
945                 950                 955                 960 


Glu Thr Lys Val Leu Lys Gln Gly Asn Phe Lys Val Leu Ala Lys Asp 
                965                 970                 975     


Arg Arg Leu Asn Gly Leu Leu Ser Phe Ala Glu Thr Thr Asp Ile Asp 
            980                 985                 990         


Leu Glu Lys Asn Pro Ile Thr Lys  Leu Ser Val Asp His  Glu Leu Ile 
        995                 1000                 1005             


Lys Tyr  Gln Thr Thr Arg Ile  Ser Ile Phe Glu Met  Thr Leu Gly 
    1010                 1015                 1020             


Leu Glu  Lys Lys Leu Ile Asp  Lys Tyr Ser Thr Leu  Pro Thr Asp 
    1025                 1030                 1035             


Ser Phe  Arg Asn Met Leu Gly  Ser Trp Leu Glu Asp  Lys Thr Asn 
    1040                 1045                 1050             


Ser Ala  Glu Leu Asn Asn Tyr  Val Asp Cys Leu Ile  Thr Val Arg 
    1055                 1060                 1065             


Asn Ala  Phe Ala His Asn Gln  Tyr Pro Met Tyr Asn  Pro Lys Leu 
    1070                 1075                 1080             


Phe Ala  Glu Val Lys Lys Phe  Ser Leu Phe Pro Ser  Ser Asn Thr 
    1085                 1090                 1095             


Lys Lys  Thr Glu Leu Asn Ile  Ala Ser Gln Leu Leu  Arg Ile Val 
    1100                 1105                 1110             


Glu Lys  Ala Ile Asp Glu Ile  Glu Lys Ser Glu Asn  Lys Asn 
    1115                 1120                 1125         


<210>  1992
<211>  1121
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1992

Met Asp Met Asp Glu Asn Ile Asn Tyr Tyr Asp Phe Asn Asn Ile Glu 
1               5                   10                  15      


Asp Lys His Phe Phe Ala Gly Tyr Tyr Asn Leu Ala Asn Asp Asn Phe 
            20                  25                  30          


Tyr Asn Val Leu Lys Glu Leu Lys Tyr Ile Ser Asp Lys Lys Leu Asp 
        35                  40                  45              


Ile Thr Glu Ile Asn Lys Ala Ser Tyr Ser Glu Leu Asp Thr Arg Leu 
    50                  55                  60                  


Asn Lys Leu Gln Arg Phe Leu Pro Phe Ile Pro Ser Leu Val Val Asp 
65                  70                  75                  80  


Lys Glu Ile Lys Asp Gln Lys Phe Glu Ile Thr Thr Leu Leu Lys Phe 
                85                  90                  95      


Leu Trp Ser Glu Ile Glu Lys Gln Arg Asn Phe Tyr Thr His Tyr Ala 
            100                 105                 110         


His Asn Arg Pro Glu Phe Ile Leu Glu Ser Asn Gln Gln Ile Leu Asn 
        115                 120                 125             


His Tyr Phe Ile Lys Ala Val Glu Leu Ile Lys Lys Ser Val Lys Asp 
    130                 135                 140                 


Glu Leu Cys Arg Asn Ser Ile Arg Glu His Phe Ser Val Glu Phe Asn 
145                 150                 155                 160 


Glu Leu Lys Val Leu Gln Lys Arg Tyr Ile Glu Glu Lys Ile Arg Asn 
                165                 170                 175     


Ser Lys Ser Asn Ser Glu Lys Lys Lys Tyr Ser Leu Asp Glu Glu Ser 
            180                 185                 190         


Ile Asn Asn Gly Ile Phe Asn Lys Leu Phe Lys Pro Tyr Ile Ile Lys 
        195                 200                 205             


Asp Lys Val Thr Gly Ile Leu Ser Ile Asn Asn Tyr Arg Leu Leu Phe 
    210                 215                 220                 


Asp Ser Ser Gly Tyr Leu Thr Lys His Gly His Leu Phe Leu Leu Ser 
225                 230                 235                 240 


Leu Phe Leu Lys Arg Asp Gln Met Glu Ser Leu Met Asp Lys Ile Glu 
                245                 250                 255     


Gly Tyr Lys Ala Ser His Lys Leu Tyr Phe His Leu Thr Arg Arg Ile 
            260                 265                 270         


Tyr Ser His Phe Cys Phe Lys Gly Ile Lys Arg Gln Ile Val Ser Gln 
        275                 280                 285             


His Ser Lys Thr Lys Leu Met Leu Gln Met Ala Asp Glu Leu Gly Lys 
    290                 295                 300                 


Ile Pro Glu Glu Leu Tyr Asn Leu Leu Asn Asn Asn Glu Lys Ala Glu 
305                 310                 315                 320 


Phe Ile Val Asp Ile Asn Glu Tyr Tyr Lys Asp Asn Asp Gln Asn Gly 
                325                 330                 335     


Glu Asn Pro Asp Glu Lys Arg Val Ile His Asp Val Val Arg Arg Arg 
            340                 345                 350         


Tyr Lys Gln Thr Asp Lys Ser Phe Ser Asp Thr Tyr Gly Thr Asn Lys 
        355                 360                 365             


Thr Ile Asp Lys Phe Glu Tyr Phe Ala Leu Arg Phe Phe Asp Glu Asp 
    370                 375                 380                 


Ser Lys Leu Lys Asn Ile Lys Phe Met Ile Asp Trp Gly Asn Val Ile 
385                 390                 395                 400 


Ile Asp Lys Arg Ser Lys Asn Ile Leu Asp Met Gln Thr Glu Arg Ile 
                405                 410                 415     


Ile Lys Lys Arg Val Thr Val Phe Glu Asn Ile Asn Thr Val Ile Asp 
            420                 425                 430         


Lys Lys Ile Glu Leu Val Asn Ser Asn Asn Cys Asn Gly Gln Ile Leu 
        435                 440                 445             


Ile Asp Glu Glu Asn Ser Thr Cys Leu Ile Glu Gly Tyr Pro Phe Pro 
    450                 455                 460                 


Ala Asn Pro Ser Tyr Tyr Phe Gln Gly His Asn Ile Pro Ile Tyr Leu 
465                 470                 475                 480 


Ser Tyr Asn Asn Lys Lys Glu Ala Asp Cys Glu Asp Thr Glu Ile Asn 
                485                 490                 495     


Lys Val Arg Asn Ala Val Leu Lys Asn Thr Leu Gly Asp Asn Val Phe 
            500                 505                 510         


Pro Asn Lys Pro Asn Ala Leu Leu Ser Leu Tyr Glu Leu Pro Ala Met 
        515                 520                 525             


Leu His Val Tyr Phe Asn His Ala Asn Lys Glu Lys Glu Val Phe Lys 
    530                 535                 540                 


Leu Leu Ile Asn Lys Tyr Phe Lys Tyr Lys Lys Asp Leu Asn Phe Lys 
545                 550                 555                 560 


Glu Asn Ile Asn Asp Asn Gln Leu Val His Leu Lys Lys Ile Lys Asn 
                565                 570                 575     


Asn Lys Ile Leu Leu Glu Lys Asn Glu Tyr Thr Phe Asn Arg Gln Lys 
            580                 585                 590         


Leu Val Ser Asp Ile Asn Lys Glu Ile Ile Lys Thr Glu Ile Lys Ile 
        595                 600                 605             


Asn Glu Phe Asn Lys Cys Lys Leu Glu Tyr His Asp Ile Lys Asn Lys 
    610                 615                 620                 


Arg Lys Tyr Leu Met Tyr Asn Ser Glu Lys Gly Leu Val Ala Thr Phe 
625                 630                 635                 640 


Leu Ala Asp Glu Ile Leu Arg Trp Met Pro Arg Asn Leu Lys Glu Asn 
                645                 650                 655     


Trp Lys Gly Tyr His His Ser Glu Leu Gln Lys Leu Leu Ser Phe Phe 
            660                 665                 670         


Gln Ile Glu Lys Asn Asn Ile Asn His Leu Ile Ile Phe Asp Asp Lys 
        675                 680                 685             


Phe Asp Phe Leu Arg Asp Ile Phe Lys Lys Ser Asn Ser Leu Glu Asp 
    690                 695                 700                 


Leu Tyr Ile Asn Tyr Leu Asn Gly Lys Ile Glu Lys Leu Lys Ser Phe 
705                 710                 715                 720 


Leu Ser Ile Leu Asp Ile Lys Glu Lys Lys Val Leu Lys Lys Gly Leu 
                725                 730                 735     


Cys Asp Ile Trp Val Phe Phe Lys Gln Ser Lys Tyr Asn Ile Lys Asn 
            740                 745                 750         


Ile Asn Ser Tyr Ser Glu Glu Leu Leu Lys Lys Pro Ile Leu Leu Gly 
        755                 760                 765             


Arg Gly Ile Phe Asp Asp Thr Pro Thr Phe Tyr Pro Ser Asp Leu Lys 
    770                 775                 780                 


Asp Asn Pro Lys Ala Asn Trp Phe Glu Thr Val Lys Lys Asn Gln Ser 
785                 790                 795                 800 


Tyr Gln Ser Phe Tyr Asn Leu Leu Glu Asp Lys Leu Lys Pro Val Ser 
                805                 810                 815     


Gly Glu Ser Ser Val Glu Lys Arg Arg Arg Ile Glu Lys Tyr Arg Ser 
            820                 825                 830         


Ile Glu Tyr Gln Lys Ile Lys Asp Ile Tyr Thr Leu Glu Met Phe Lys 
        835                 840                 845             


His Leu Tyr Lys Glu Ile Phe Gly Asn Glu Glu Ile Met Glu Asn Ile 
    850                 855                 860                 


Thr Leu Thr Asp Phe Tyr Gln Ser Pro Ala Glu Arg Lys Lys Met Ile 
865                 870                 875                 880 


Ala Asn Ala Ser Ser Gln Asn Asn Arg Asn Gln Gly Asn Cys Ser Lys 
                885                 890                 895     


Asn Lys Tyr Asn Glu Leu Gly Ile Trp Asn Lys Val Thr Pro Cys Asn 
            900                 905                 910         


Phe Glu Asn Gly Arg Val Val Ala Pro Gln Ile Lys Leu Lys Glu Ile 
        915                 920                 925             


Gly Lys Phe Glu Gln Leu Leu Leu Asp Asp Lys Val Lys Ala Ile Leu 
    930                 935                 940                 


Ser Tyr Asn Asp Gln Ile Trp Gln Lys Gln Glu Leu Glu Arg Glu Leu 
945                 950                 955                 960 


Glu Ser Tyr Arg Ile Val Arg Glu Glu Lys Leu Phe Lys Ile Ile His 
                965                 970                 975     


Asn Leu Glu Lys Val Ile Leu Glu Ile Glu Thr Leu His Arg Glu Asp 
            980                 985                 990         


Lys Ser His Pro Ile Ile Phe Asn  Asn Gly Glu Tyr Pro  Asn Phe Arg 
        995                 1000                 1005             


Lys Tyr  Ile Glu Asn Ser Lys  Ile Phe Asn Trp Ser  Gln Glu Asp 
    1010                 1015                 1020             


Lys Asn  Ile Ile Asn Cys Phe  Asn Ser Glu Leu Leu  Glu Asn Ser 
    1025                 1030                 1035             


Phe Pro  Glu Ile Ile Val Asn  Ala Asn Pro Arg Leu  Gln Lys Ala 
    1040                 1045                 1050             


Ile Leu  Leu Ile Tyr Ile Arg  Asn Lys Phe Ala His  Asn Gln Leu 
    1055                 1060                 1065             


Pro Ser  Lys His Val His Asn  Phe Cys Lys Lys Ile  Ser Cys Ile 
    1070                 1075                 1080             


Asn Asp  Glu Arg Val Thr Thr  Tyr Ala Glu Phe Tyr  Leu Met Ile 
    1085                 1090                 1095             


Val Glu  Asn Phe Ile Leu Asp  Gln Asn Phe Ile Lys  Thr Lys Gln 
    1100                 1105                 1110             


Val Tyr  Asn Asn Asn Ser Ile  Ser 
    1115                 1120     


<210>  1993
<211>  1144
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1993

Met Asp Ile Ile Pro Lys Leu Thr Tyr Thr Ile Glu Ser Thr Pro Trp 
1               5                   10                  15      


Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg His Asn Val Tyr Leu Leu 
            20                  25                  30          


Ile Asn His Leu Thr Glu Lys Phe Ser His Leu Lys Tyr Glu Lys Leu 
        35                  40                  45              


Lys Asp Asp Lys Glu Ile Lys Gly Lys Asn Ile Leu Thr Glu Ile Phe 
    50                  55                  60                  


Asp Thr Thr Lys Ser Asp Leu Asp Glu Glu Arg Phe Arg Ile Tyr Lys 
65                  70                  75                  80  


Tyr Leu Val Arg Gly His Tyr Leu Pro Phe Ile Lys Val Tyr Ser Asp 
                85                  90                  95      


Ser Lys Gly Asn Ala Leu Glu Asn Asn Pro Leu Val Tyr Tyr Asp Arg 
            100                 105                 110         


Leu His Gln Phe Ile Asn Asn Ser Phe Ala Leu Leu Val Lys Phe Arg 
        115                 120                 125             


Asp Ala Phe Ser His Tyr Leu Ala Leu Asp Glu His Gly Asn Ser Ile 
    130                 135                 140                 


Asp Ser Arg Gln Leu Asn Ile Asp His Glu Ile Ala His Asp Leu Glu 
145                 150                 155                 160 


Thr Ile Phe Gln Asp Ser Leu Ser Leu Ser Ala Ser Arg Phe Tyr Leu 
                165                 170                 175     


Thr Gln Gln Glu Ser Asp Phe Glu His Leu Lys His Tyr Ala Leu Phe 
            180                 185                 190         


Lys Glu Thr Glu Thr Lys Leu Ser Glu Asn Gly Phe Tyr Phe Phe Ile 
        195                 200                 205             


Cys Leu Phe Leu Glu Lys Gln Tyr Ala Ile Lys Phe Leu Lys Lys Ile 
    210                 215                 220                 


Lys Gly Phe Lys Asn Glu Thr Ile Pro Ala Phe Arg Ala Thr Leu Leu 
225                 230                 235                 240 


Ala Phe Thr His Tyr Thr Ile Arg Ile Pro Asp Ile Arg Leu Asp Asn 
                245                 250                 255     


Asp Glu Pro Arg Met Gly Val Leu Met Glu Met Leu Asn Glu Leu Gln 
            260                 265                 270         


Lys Cys Pro Ile Glu Leu Tyr Lys Arg Leu Thr Asp Glu Asp Lys Lys 
        275                 280                 285             


Lys Phe Glu Pro Ala Leu Asp Glu Glu Ser Gln Leu Asn Leu Ile Leu 
    290                 295                 300                 


Asn Ser Thr Ala Asn Ser Glu Asn Leu Ser Asp Glu Gln Thr Asp Ser 
305                 310                 315                 320 


Leu Leu Ile Asp Leu Thr Thr Leu Lys Arg His Gln Asn Arg Phe Ser 
                325                 330                 335     


Tyr Phe Ala Leu Arg Cys Ile Asp Glu Leu Asn Leu Leu Pro Gly Ile 
            340                 345                 350         


His Phe Gln Ile Thr Val Gly Lys Ile Glu Leu Arg Ala Tyr Pro Lys 
        355                 360                 365             


Val Ile Gly Lys Val Ala Thr Asn Arg Arg Ile Leu Lys Glu Val Asn 
    370                 375                 380                 


Ala Phe Gly Lys Leu Ser Ala Tyr Glu Gly Lys Glu Asn Trp Phe Ser 
385                 390                 395                 400 


Gln Gln Leu Lys Met Ile Tyr Glu Asp Glu Asn Leu Val Phe Asp Gln 
                405                 410                 415     


Tyr Asn Pro His Tyr Asn Ile Gln Glu Asn Lys Ile Ala Phe Tyr Val 
            420                 425                 430         


Leu Asp Ser Gly Thr Ser Gly Thr Leu Leu Pro Leu Lys Lys Lys Asn 
        435                 440                 445             


Thr Leu Pro Thr Gly Phe Leu Ser Leu Asn Asp Leu Pro Lys Leu Ile 
    450                 455                 460                 


Val Arg Ala Leu Asn Ser Pro Gly Arg Thr Val Ser Leu Ile Lys Asp 
465                 470                 475                 480 


Phe Ile Ala Lys Asn Glu Asn Ile Ile Leu Asn Glu Asp Ala Leu Val 
                485                 490                 495     


Ala Trp Lys Glu Gln Leu His Leu Asp Pro Ala Val Phe Thr Arg Arg 
            500                 505                 510         


Ile Ile Lys Glu Asn Ala Leu Arg Gly Lys Glu Gly Ile Ala Tyr Leu 
        515                 520                 525             


Thr Gln Arg Lys Thr Asp Ala Leu Phe Lys Arg Tyr Lys Ala Leu Ser 
    530                 535                 540                 


Ile Lys Ile Asp Ser Leu Ala Gly Leu Lys Lys Leu Ile Asp Gln Leu 
545                 550                 555                 560 


His Ser Lys Lys Asp Lys Glu Tyr Ile Ser Gln Ile Val Tyr Thr His 
                565                 570                 575     


Phe Leu Asn Lys Arg Lys Asp Ala Leu Ala Gly Ile Leu Pro Lys Gly 
            580                 585                 590         


Leu Pro Val Asn Gln Leu Pro Leu Lys Val Ile Asn Tyr Leu Leu Ser 
        595                 600                 605             


Leu Glu Thr Val Gly His Lys Lys Lys Phe Leu His Tyr Ile Lys Glu 
    610                 615                 620                 


Glu Lys Arg Thr Cys Lys Thr Arg Leu Lys Ala Leu Asn Lys Gln Glu 
625                 630                 635                 640 


Asn Asn Ala Pro Lys Ile Gly Glu Ile Ala Thr Phe Leu Ala Arg Asp 
                645                 650                 655     


Ile Ile Asn Met Val Val Asn Glu Glu Thr Lys Gln Asn Ile Thr Ser 
            660                 665                 670         


Ala Tyr Tyr Asn Arg Leu Gln Asn Lys Ile Ala Tyr Phe Ser Ile Ser 
        675                 680                 685             


Lys Pro Glu Ile Ala Glu Met Leu Thr Glu Leu Asn Leu Phe Asp Lys 
    690                 695                 700                 


Lys Thr Gly His Pro Phe Leu Asp Lys Gly Ser Ile Met Ala Ser Ser 
705                 710                 715                 720 


Gly Ile Leu Ala Phe Tyr Glu Tyr Tyr Leu Val Glu Lys Ala Ala Trp 
                725                 730                 735     


Ile Asp Lys Gln Ile Leu His Lys Asn Gln Leu Lys Lys Asp Leu Glu 
            740                 745                 750         


Ser His Leu Asn Lys Leu Pro Phe Ala Tyr Ala Arg Arg Tyr Gln Lys 
        755                 760                 765             


Asn Asn Glu Val Asn Phe Thr Lys Trp Leu Ile Asn Lys Lys Val Met 
    770                 775                 780                 


Pro Val Asn Ile Pro Asn Asn Leu Phe Asp Ala Asp Val Asn Lys Ile 
785                 790                 795                 800 


Leu Lys Asp Ser Leu Arg Lys Met Gly Ile Ala Phe Lys Asp Thr Glu 
                805                 810                 815     


Lys Phe Ala Leu Leu Leu Ser Lys Ser Met Met Gly Asp Thr Gln Pro 
            820                 825                 830         


Phe Tyr Thr Tyr Lys Arg Glu Tyr Thr Val Asp Gly Glu Lys Ile Pro 
        835                 840                 845             


Phe Tyr Pro Ala Asn Gln Ser Gly Lys Asp Ile Lys Thr Asp Tyr Gly 
    850                 855                 860                 


Lys His Ala Asp Ala Ser Glu Lys Glu Ile Arg Phe Ile Gln Thr Gln 
865                 870                 875                 880 


Asp Arg Val Ile Lys Leu Leu Cys Arg Asn Ile Ile Gln Ser Ile Val 
                885                 890                 895     


Lys Phe Lys Glu Ser Asn Leu Asp Ile Ile Leu Asn Asn Ile Tyr Pro 
            900                 905                 910         


Phe Ser Glu Thr Ser Val Leu Asn Ala Pro Gln Lys Phe Glu Phe Thr 
        915                 920                 925             


Leu Pro Lys Asn Gly Lys Lys Lys Ile Ile Val Ala Glu Asp Thr Ser 
    930                 935                 940                 


Ala Gln Lys Glu Gln Val Leu Arg Tyr Lys Gly Leu Ser Asp Leu Glu 
945                 950                 955                 960 


Glu Arg Lys Gln Tyr Asn Gly Gln Lys Gly Tyr Gln Trp Thr Ile Lys 
                965                 970                 975     


Asp Phe Gly Arg Phe Lys Arg Phe Val His Asp Arg Arg Leu Ser Glu 
            980                 985                 990         


Val Leu Asp Tyr Ile Asp Ala Pro  Asn Ala Thr Phe Asp  Leu Leu Ala 
        995                 1000                 1005             


Tyr Gln  Leu Asp Glu Tyr Asp  Arg Tyr Arg Val Glu  Ile Phe Gln 
    1010                 1015                 1020             


Gln Thr  Phe Asp Phe Glu Lys  Ala Ile Ala Ile Lys  His Leu Asp 
    1025                 1030                 1035             


Arg Val  Lys His Phe Asp Ser  Ile Asp Lys Ala Gly  Lys Lys Gly 
    1040                 1045                 1050             


Lys Ile  Ala Glu Val Ser Phe  Arg Val Tyr Leu Asp  Val Leu Lys 
    1055                 1060                 1065             


Glu Leu  Lys Ile Leu Ala Thr  Asp Glu Ala Asp Leu  Leu Lys Asn 
    1070                 1075                 1080             


Val Arg  Asn Lys Phe Ser His  Ser Glu Phe Pro Pro  Phe Ile Lys 
    1085                 1090                 1095             


Ser Leu  Thr Lys Ile Thr Ser  Glu Asn Ile Ala Ser  Phe Glu Ala 
    1100                 1105                 1110             


Asn Lys  Phe Thr Lys Asp Ala  Ile Ser Ala Leu Asp  Ile Ser Val 
    1115                 1120                 1125             


Pro Ser  Lys Ile Leu Asn Glu  Tyr Lys Ala Val Leu  Ser Lys Phe 
    1130                 1135                 1140             


Ser 
    


<210>  1994
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1994

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Ile Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Val Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Ala Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1995
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1995

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Ile Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1996
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1996

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1997
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1997

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Ile Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1998
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1998

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Ile Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  1999
<211>  1140
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  1999

Met Glu Asn Asp Gln Gln Ile Leu Glu Asn Arg Arg Arg Thr Leu Ala 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Ser Asn His Leu Ala Thr Ser Phe Glu Gln Lys Ala 
        35                  40                  45              


Leu His Glu Glu Gly Gln Ile Pro Ala Ser Phe Leu Cys Asn Lys Ser 
    50                  55                  60                  


Ile Lys Lys Ile Asn Trp Asn His Val Tyr Ser Lys Ala Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Ile Phe Asp Ala Asp Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Arg Glu Thr Ser Asp Lys Glu Gly Lys Asp Phe Thr Ala Met Asn Glu 
            100                 105                 110         


Thr Leu Lys Leu Val Phe Asp Glu Leu Gln Ala Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Ala Asp Ser Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Val Glu Leu Ala Asp Phe Leu Thr Val Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Ala Asp Asp Asp Tyr 
                165                 170                 175     


Ala Val Val Glu Ser Lys Gln Ile Val Thr Pro Asp Asn Gln Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Ile Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Val Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Leu Ala Tyr Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asp Leu Arg Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Glu 
            260                 265                 270         


Val Ile Thr Glu Glu Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Glu Glu Glu Arg 
    290                 295                 300                 


Glu Lys Ile Leu Asp Glu Ile Asp Tyr Glu Asp Tyr Ile Glu Ser Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg His Ser Asn Arg Phe Pro Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Glu Lys Tyr Asn Lys Gln Phe Asp Gly Glu 
        355                 360                 365             


Ala Thr Glu Arg Lys Val Val Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asn Gln Glu Thr Val Glu Leu Lys Ile Asp Ser Ala 
385                 390                 395                 400 


Gln Arg Thr Asn Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Glu Ala Arg Leu Leu 
            420                 425                 430         


Thr Lys Ala Lys Pro Glu Ser Lys Val Ser Tyr Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Lys Ala Glu Glu Met Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Lys Val Asn Asp Ser Gln Leu Met Asn Met Gln Phe Ile Asp Glu 
                485                 490                 495     


Ile Lys Glu Gln Leu Pro Ala Asp Trp Asn Glu Phe Gly Lys Arg Ser 
            500                 505                 510         


Asp Ser Lys Lys Lys Lys Ala Tyr Thr Asn Ala Ala Arg Gln Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Lys Val Leu Ala Asn Tyr Gln Leu 
    530                 535                 540                 


Asn Asp Lys Gln Val Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Val 
545                 550                 555                 560 


Lys Glu Val Asp Asp Ser Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Met Glu Lys His Lys Val 
            580                 585                 590         


Asp Lys Ser Ala Arg Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Thr Asp Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Tyr 
625                 630                 635                 640 


Ala Asp Asn Glu Lys Lys Ala Thr Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Lys Asp Gly His Pro Phe Leu Ala Asn Ile Asn 
            660                 665                 670         


Leu Arg Gln Ile Arg Lys Thr Ser Gln Leu Tyr Glu Leu Tyr Leu Val 
        675                 680                 685             


Glu Lys Ala Asn Lys Gln Val Lys Lys Met Asn Pro Lys Thr Gln Arg 
    690                 695                 700                 


Thr Asn Asn Val Asp Glu Ser Trp Met Met Lys Ser Phe Tyr Ala Lys 
705                 710                 715                 720 


Glu Trp Asn Glu Glu Met Gly Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Thr Asn Ile Pro Phe Thr Ile Arg Gln Trp Glu Glu Lys 
            740                 745                 750         


Glu Lys His Asn Leu Gln Ala Trp Leu His Asn Ile Thr Lys Gly Lys 
        755                 760                 765             


Thr Ser Lys Asp Gly Lys Lys Ala Val Asp Leu Pro Thr Asn Leu Phe 
    770                 775                 780                 


Asp Asp Thr Leu Cys Glu Leu Leu Arg Glu Ala Leu Ile Asn Glu Gly 
785                 790                 795                 800 


Ile Asp Ala Thr Pro Thr Thr Lys Tyr Asn Glu Leu Leu Lys His Trp 
                805                 810                 815     


Trp Thr Ala Arg Glu Asp Ser Thr Gln Asp Phe Tyr Leu Ser Glu Arg 
            820                 825                 830         


Gln Tyr Asp Ile Tyr Asp Glu Lys Val Cys Phe Thr Ile Asn Ser Ser 
        835                 840                 845             


Ala His Phe Ala Asp Tyr Tyr Ala Pro Ala Leu Ser Lys Ala Tyr Ser 
    850                 855                 860                 


Arg Leu Arg Ala Glu Arg Asp Val Ala Arg Arg Thr Asp Lys Arg Leu 
865                 870                 875                 880 


Pro Pro Val Glu Arg Lys Asp Val Glu Arg Val Phe Lys Asn Thr Ile 
                885                 890                 895     


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
            900                 905                 910         


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asn Gln Gln Gln Leu Lys 
        915                 920                 925             


Leu Ser Lys Met Asp Ser Leu Leu Asn Glu Thr Lys Arg Ile Glu Gln 
    930                 935                 940                 


Val Ile Asn Thr Gln Leu Ser Phe Asp Gln Lys Gly Lys Glu Ile Lys 
945                 950                 955                 960 


Asp Lys Thr Asn Leu Glu Ile Val Lys Thr Ile Val Ala Glu Arg Lys 
                965                 970                 975     


Gln Lys Asn Tyr Thr Glu Met Arg Lys Tyr Val His Asp Arg Arg Leu 
            980                 985                 990         


Pro Glu Leu Phe Glu Tyr Ile Asp  Gly Asn Glu Leu Pro  Leu Asp Met 
        995                 1000                 1005             


Leu Leu  Asn Glu Leu Arg Ala  Tyr Asn Thr Ala Lys  Gln Val Val 
    1010                 1015                 1020             


Phe Asp  Thr Val Phe Ala Leu  Glu Lys Lys Ile Ile  Glu Thr Asp 
    1025                 1030                 1035             


Pro Glu  Gly Leu Lys Gln Leu  Asn Val Ser Lys Asp  Gly Gln Ile 
    1040                 1045                 1050             


Gln Thr  Gly Asn Ile Gln His  Lys Pro Tyr Val Gln  Trp Leu Glu 
    1055                 1060                 1065             


Asn Lys  Gly Leu Ile Thr Asp  Lys Asp Lys Gln Phe  Ile Asn Met 
    1070                 1075                 1080             


Val Arg  Asn Ser Phe Ser His  Asn Gln Phe Pro Gln  Arg Ser Thr 
    1085                 1090                 1095             


Val Glu  Leu Leu Met Pro Val  Trp Gln Asn Thr Asn  Ile Ala Leu 
    1100                 1105                 1110             


Gln Ile  Ala Arg Glu Tyr Gln  Gln Leu Ile Val Asp  Ile Ile Glu 
    1115                 1120                 1125             


Lys Ser  Leu His Pro His Lys  Gln His Gln Met Val  
    1130                 1135                 1140 


<210>  2000
<211>  1126
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2000

Met Glu Thr Leu Leu Thr Pro Thr Glu Asn Lys Tyr Arg Thr Ile Asn 
1               5                   10                  15      


Asp Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Ser Met Ala Arg Leu Asn 
            20                  25                  30          


Val Phe Asn Ile Ser Asn His Ile Ala Lys Glu Phe Gly Gln Ser Leu 
        35                  40                  45              


Leu Glu Glu Glu Gly His Ile Lys Asn Ser Phe Leu Cys Asp Lys Asn 
    50                  55                  60                  


Asn Lys Lys Val Asn Trp Asn His Val His Ala Lys Ala Arg Arg Phe 
65                  70                  75                  80  


Leu Ser Ile Leu Lys Val Phe Asp Ala Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Leu Lys Ile Ile Glu Trp Glu Gly Lys Asp Phe Ser Leu Met Gly Asp 
            100                 105                 110         


Thr Leu Lys Ile Val Phe Arg Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Phe Tyr Ser Thr Glu Lys Gly Thr Ser Arg Lys Ile Lys Val 
    130                 135                 140                 


Ser Glu Glu Leu Ala Glu Phe Leu Lys Thr Asn Phe Arg Arg Ala Ile 
145                 150                 155                 160 


Glu Tyr Thr Lys Glu Arg Phe Lys Gly Gly Leu Ile Glu Glu Asp Phe 
                165                 170                 175     


Asn Leu Val Ala Ser Arg Lys Val Val Arg Asp Asp Leu Ala Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ala Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Thr Gly Leu Lys Gly Thr Gln Asn 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro His Asp Arg Phe Gln Ser Asp Asn Thr Arg Gln Ala Phe Ser 
                245                 250                 255     


Leu Asp Leu Ile Asn Glu Leu Asn Arg Cys Pro Lys Val Leu Tyr Asn 
            260                 265                 270         


Val Ile Thr Glu Glu Gly Lys Gln Leu Phe Arg Pro Gln Leu Glu Asp 
        275                 280                 285             


Leu Glu Ile Lys Asn Leu Ile Lys Asn Ser Thr Asn Asn Glu Glu Glu 
    290                 295                 300                 


Ile Asp Asn Tyr Asp Glu Tyr Ile Glu Ala Leu Thr Lys Arg Ile Arg 
305                 310                 315                 320 


His Thr Asn Arg Phe Ser Asp Phe Ala Leu Gln Phe Ile Asp Glu Thr 
                325                 330                 335     


Asp Val Phe Lys Lys Phe Arg Phe Gln Ile Asp Leu Gly Lys Leu Leu 
            340                 345                 350         


Val Asp Glu Tyr Asp Lys Ser Phe Asn Gly Glu Glu Val Glu Arg Lys 
        355                 360                 365             


Ile Ile Val Asn Ala Lys Ala Phe Arg Lys Leu Asn Ser Tyr Gly Thr 
    370                 375                 380                 


Glu Asp Glu Thr Leu Lys Leu Ile Glu Asn Gly Gln Gly Ser Lys Arg 
385                 390                 395                 400 


Phe Glu Gln Phe Ala Pro His Tyr Asn Thr Glu Asn Asn Lys Ile Gly 
                405                 410                 415     


Leu Ser Gly Lys Glu Leu Ile Ala Lys Leu Arg Pro Asn Ser Lys Gly 
            420                 425                 430         


Glu Ala Gly Lys Lys Leu His Gln Pro Leu Pro Glu Ala Phe Leu Ser 
        435                 440                 445             


Leu Lys Glu Leu Pro Lys Ile Ile Leu Leu Asn Tyr Leu Leu Pro Asp 
    450                 455                 460                 


Glu Pro Glu Lys Leu Ile Asn Asp Phe Ile Leu Val Asn Asn Ser Lys 
465                 470                 475                 480 


Leu Met Asn Met Ser Phe Ile Lys Glu Val Lys Ser Leu Leu Pro Lys 
                485                 490                 495     


Glu Trp Asn Glu Phe Lys Lys Arg Ser Asp Thr Lys Lys Gln Arg Ala 
            500                 505                 510         


Tyr Asn Glu Lys Ala Leu Ala Tyr Leu Leu His Arg Lys Gln Ile Leu 
        515                 520                 525             


Asn Gln Val Leu Ala Ala Tyr Gln Leu Asn Asp Lys Gln Ile Pro Arg 
    530                 535                 540                 


Arg Ile Leu Asp Tyr Trp Leu Asn Ile Val Asp Val Val Glu Gly Arg 
545                 550                 555                 560 


Ser Val Ser Asp Arg Ile Lys Met Met Lys Arg Asp Cys Met Ser Arg 
                565                 570                 575     


Leu Lys Ala Met Ala Lys Phe Lys Glu Asp Arg Asn Arg Asn Lys Ile 
            580                 585                 590         


Pro Lys Ile Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile Val Asp 
        595                 600                 605             


Met Val Val Gly Glu Glu Lys Lys Gln Lys Ile Thr Ser Phe Tyr Tyr 
    610                 615                 620                 


Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Pro Glu Lys Lys 
625                 630                 635                 640 


Gln Leu Phe Ile His Thr Val Ile Asn Glu Leu Lys Leu Asn Glu Gln 
                645                 650                 655     


Gly Gly His Pro Phe Leu His Lys Leu Asn Leu Gln Gln Ile Lys Asn 
            660                 665                 670         


Thr Ser Gly Phe Tyr Glu Ile Tyr Leu Gln Glu Lys Gly Gln Lys Met 
        675                 680                 685             


Val Ser Glu Lys Asn Phe Arg Thr Gly Arg Thr Ile Glu Thr Asp Lys 
    690                 695                 700                 


Ser Trp Met Ala Leu Thr Phe Tyr Lys Lys Glu Trp Asp Glu Lys Val 
705                 710                 715                 720 


Gly Lys Gln Leu Thr Val Val Arg Leu Pro Glu Asn Lys Ser Asn Ile 
                725                 730                 735     


Pro Phe Ser Leu Arg Leu Leu Glu Glu Lys Thr Val Tyr Thr Leu Glu 
            740                 745                 750         


Gln Trp Leu His Asn Val Thr Lys Gly Lys Lys Gln Asn Asp Thr Arg 
        755                 760                 765             


Gln Pro Val Asn Leu Pro Thr Asn Leu Phe Asp Glu Arg Leu Thr Val 
    770                 775                 780                 


Leu Leu Arg Gly Glu Leu Asp Lys Lys Gln Ile Ser Tyr Ala Pro Asn 
785                 790                 795                 800 


Ala Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Lys Ser Arg Asn Asp 
                805                 810                 815     


Ser Val Gln Ser Phe Tyr Lys Ala Glu Arg Glu Tyr Glu Ile Phe Gly 
            820                 825                 830         


Glu Lys Val Asn Phe Met Pro Asp Ser Lys Glu Arg Phe Ala Asp Tyr 
        835                 840                 845             


Tyr Gln His Ala Leu Thr Ala Ala Trp Gln Lys Lys Arg Lys Glu Arg 
    850                 855                 860                 


Ile Gln Gln Gln Lys Gln Asp Arg Arg Leu Pro Asp Ile Ser Phe Asp 
865                 870                 875                 880 


Gln Val Glu Lys Thr Phe Lys Gln Thr Ile Ala Glu Thr Glu Lys Glu 
                885                 890                 895     


Ile Arg Ile Val Gln Glu Glu Asp Arg Met Met Leu Leu Met Leu Glu 
            900                 905                 910         


Thr Leu Met Glu Asn Gly Lys Asp Leu Lys Leu Lys Leu Ser Gly Ile 
        915                 920                 925             


Asp Thr Leu Leu Asn Ala Thr Thr Glu Val Lys Gln Leu Val Ser Gly 
    930                 935                 940                 


Lys Leu Ser Phe Asn Gly Ser Gly Glu Leu Ile Lys Gly Lys Thr Asn 
945                 950                 955                 960 


Pro Glu Ile Ser Lys Thr Ile Thr Val Ala Arg Lys Arg Lys Asp Tyr 
                965                 970                 975     


Ser Met Leu Arg Lys Phe Val Phe Asp Arg Arg Leu Pro Glu Leu Phe 
            980                 985                 990         


Glu Tyr Phe Ala Glu Glu Glu Ile  Pro Ile Glu Val Leu  Lys Asp Glu 
        995                 1000                 1005             


Leu Asp  Ala Tyr Asn Lys Ala  Lys His Glu Val Phe  Asp Thr Val 
    1010                 1015                 1020             


Phe Glu  Leu Glu Glu Lys Ile  Ile Thr Leu Asp Ala  Asp Gly Ile 
    1025                 1030                 1035             


Arg Gln  Leu Phe Ile Asp Asp  Ala Gly Gln Pro Val  Thr Gly Asn 
    1040                 1045                 1050             


Ile Gln  His Lys Pro Tyr Val  Ile Trp Leu Lys Asn  Asn Gly Thr 
    1055                 1060                 1065             


Ile Asp  Asp Asn Thr Leu Thr  Phe Leu Asn Met Val  Arg Asn Cys 
    1070                 1075                 1080             


Phe Ser  His Asn Gln Tyr Pro  Gln Lys Lys Thr Met  Glu Leu Leu 
    1085                 1090                 1095             


Ile Gly  Gln Trp Glu Pro Asn  Arg Phe Ala Leu Thr  Ile Ala Gln 
    1100                 1105                 1110             


Thr Tyr  Lys Arg Lys Ile Asn  Ser Ile Met Lys His  Leu 
    1115                 1120                 1125     


<210>  2001
<211>  1144
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2001

Met Asp Ile Ile Pro Lys Leu Thr Tyr Thr Ile Glu Ser Thr Pro Trp 
1               5                   10                  15      


Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg His Asn Val Tyr Leu Leu 
            20                  25                  30          


Ile Asn His Leu Thr Glu Lys Phe Ser His Leu Lys Tyr Glu Lys Leu 
        35                  40                  45              


Lys Asp Asp Lys Glu Ile Lys Gly Lys Asn Ile Leu Thr Glu Ile Phe 
    50                  55                  60                  


Asp Thr Thr Lys Ser Asp Leu Asp Glu Glu Arg Phe Arg Ile Tyr Lys 
65                  70                  75                  80  


Tyr Leu Val Arg Gly His Tyr Leu Pro Phe Ile Lys Val Tyr Ser Asp 
                85                  90                  95      


Ser Lys Gly Asn Ala Leu Glu Asn Asn Pro Leu Val Tyr Tyr Asp Arg 
            100                 105                 110         


Leu His Gln Phe Ile Asn Asn Ser Phe Ala Leu Leu Val Lys Phe Arg 
        115                 120                 125             


Asp Ala Phe Ser His Tyr Leu Ala Leu Asp Glu His Gly Asn Ser Ile 
    130                 135                 140                 


Asp Ser Arg Gln Leu Asn Ile Asp His Glu Ile Ala His Asp Leu Glu 
145                 150                 155                 160 


Thr Ile Phe Gln Asp Ser Leu Ser Leu Ser Ala Ser Arg Phe Tyr Leu 
                165                 170                 175     


Thr Gln Gln Glu Ser Asp Phe Glu His Leu Lys His Tyr Ala Leu Phe 
            180                 185                 190         


Lys Glu Thr Glu Thr Lys Leu Ser Glu Asn Gly Phe Tyr Phe Phe Ile 
        195                 200                 205             


Cys Leu Phe Leu Glu Lys Gln Tyr Ala Ile Lys Phe Leu Lys Lys Ile 
    210                 215                 220                 


Lys Gly Phe Lys Asn Glu Thr Ile Pro Ala Phe Arg Ala Thr Leu Leu 
225                 230                 235                 240 


Ala Phe Thr His Tyr Thr Ile Arg Ile Pro Asp Ile Arg Leu Asp Asn 
                245                 250                 255     


Asp Glu Pro Arg Met Gly Val Leu Met Glu Met Leu Asn Glu Leu Gln 
            260                 265                 270         


Lys Cys Pro Ile Glu Leu Tyr Lys Arg Leu Thr Asp Glu Asp Lys Lys 
        275                 280                 285             


Lys Phe Glu Pro Ala Leu Asp Glu Glu Ser Gln Leu Asn Leu Ile Leu 
    290                 295                 300                 


Asn Ser Thr Ala Asn Ser Glu Asn Leu Ser Asp Glu Gln Thr Asp Ser 
305                 310                 315                 320 


Leu Leu Ile Asp Leu Thr Thr Leu Lys Arg His Gln Asn Arg Phe Ser 
                325                 330                 335     


Tyr Phe Ala Leu Arg Cys Ile Asp Glu Leu Asn Leu Leu Pro Gly Ile 
            340                 345                 350         


His Phe Gln Ile Thr Val Gly Lys Ile Glu Leu Arg Ala Tyr Pro Lys 
        355                 360                 365             


Val Ile Gly Lys Val Ala Thr Asn Arg Arg Ile Leu Lys Glu Val Asn 
    370                 375                 380                 


Ala Phe Gly Lys Leu Ser Ala Tyr Glu Gly Lys Glu Asn Trp Phe Ser 
385                 390                 395                 400 


Gln Gln Leu Lys Met Ile Tyr Glu Asp Glu Asn Leu Val Phe Asp Gln 
                405                 410                 415     


Tyr Asn Pro His Tyr Asn Ile Gln Glu Asn Lys Ile Ala Phe Tyr Val 
            420                 425                 430         


Leu Asp Ser Gly Thr Ser Gly Thr Leu Leu Pro Leu Lys Lys Lys Asn 
        435                 440                 445             


Thr Leu Pro Thr Gly Phe Leu Ser Leu Asn Asp Leu Pro Lys Leu Ile 
    450                 455                 460                 


Val Arg Ala Leu Asn Ser Pro Gly Arg Thr Val Ser Leu Ile Lys Asp 
465                 470                 475                 480 


Phe Ile Ala Lys Asn Glu Asn Ile Ile Leu Asn Glu Asp Ala Leu Val 
                485                 490                 495     


Ala Trp Lys Glu Gln Leu His Leu Asp Pro Ala Val Phe Thr Arg Arg 
            500                 505                 510         


Ile Ile Lys Glu Asn Ala Leu Arg Gly Lys Glu Gly Ile Ala Tyr Leu 
        515                 520                 525             


Thr Gln Arg Lys Thr Asp Ala Leu Phe Lys Arg Tyr Lys Ala Leu Ser 
    530                 535                 540                 


Ile Lys Ile Asp Ser Leu Ala Gly Leu Lys Lys Leu Ile Asp Gln Leu 
545                 550                 555                 560 


His Ser Lys Lys Asp Lys Glu Tyr Ile Ser Gln Ile Val Tyr Thr His 
                565                 570                 575     


Phe Leu Asn Lys Arg Lys Asp Ala Leu Ala Gly Ile Leu Pro Lys Gly 
            580                 585                 590         


Leu Pro Val Asn Gln Leu Pro Leu Lys Val Ile Asn Tyr Leu Leu Ser 
        595                 600                 605             


Leu Glu Thr Val Gly His Lys Lys Lys Phe Leu His Tyr Ile Lys Glu 
    610                 615                 620                 


Glu Lys Arg Thr Cys Lys Thr Arg Leu Lys Ala Leu Asn Lys Gln Glu 
625                 630                 635                 640 


Asn Asn Ala Pro Lys Ile Gly Glu Ile Ala Thr Phe Leu Ala Arg Asp 
                645                 650                 655     


Ile Ile Asn Met Val Val Asn Glu Glu Thr Lys Gln Asn Ile Thr Ser 
            660                 665                 670         


Ala Tyr Tyr Asn Arg Leu Gln Asn Lys Ile Ala Tyr Phe Ser Ile Ser 
        675                 680                 685             


Lys Pro Glu Ile Ala Glu Met Leu Thr Glu Leu Asn Leu Phe Asp Lys 
    690                 695                 700                 


Lys Thr Gly His Pro Phe Leu Asp Lys Gly Ser Ile Met Ala Ser Ser 
705                 710                 715                 720 


Gly Ile Leu Ala Phe Tyr Glu Tyr Tyr Leu Val Glu Lys Ala Ala Trp 
                725                 730                 735     


Ile Asp Lys Gln Ile Leu His Lys Asn Gln Leu Lys Lys Asp Leu Glu 
            740                 745                 750         


Ser His Leu Asn Lys Leu Pro Phe Ala Tyr Ala Arg Arg Tyr Gln Lys 
        755                 760                 765             


Asn Asn Glu Val Asn Phe Thr Lys Trp Leu Ile Asn Lys Lys Val Met 
    770                 775                 780                 


Pro Val Asn Ile Pro Asn Asn Leu Phe Asp Ala Asp Val Asn Lys Ile 
785                 790                 795                 800 


Leu Lys Asp Ser Leu Arg Lys Met Gly Ile Ala Phe Lys Asp Thr Glu 
                805                 810                 815     


Lys Phe Ala Leu Leu Leu Ser Lys Ser Met Met Gly Asp Thr Gln Pro 
            820                 825                 830         


Phe Tyr Thr Tyr Lys Arg Glu Tyr Thr Val Asp Gly Glu Lys Ile Pro 
        835                 840                 845             


Phe Tyr Pro Ala Asn Gln Ser Gly Lys Asp Ile Lys Thr Asp Tyr Gly 
    850                 855                 860                 


Lys His Ala Asp Ala Ser Glu Lys Glu Ile Arg Phe Ile Gln Thr Gln 
865                 870                 875                 880 


Asp Arg Val Ile Lys Leu Leu Cys Arg Asn Ile Ile Gln Ser Ile Val 
                885                 890                 895     


Lys Phe Lys Glu Ser Asn Leu Asp Ile Ile Leu Asn Asn Ile Tyr Pro 
            900                 905                 910         


Phe Ser Glu Thr Ser Val Leu Asn Ala Pro Gln Lys Phe Glu Phe Thr 
        915                 920                 925             


Leu Pro Lys Asn Gly Lys Lys Lys Ile Ile Val Ala Glu Asp Thr Ser 
    930                 935                 940                 


Ala Gln Lys Glu Gln Val Leu Arg Tyr Lys Gly Leu Ser Asp Leu Glu 
945                 950                 955                 960 


Glu Arg Lys Gln Tyr Asn Gly Gln Lys Gly Tyr Gln Trp Thr Ile Lys 
                965                 970                 975     


Asp Phe Gly Arg Phe Lys Arg Phe Val His Asp Arg Arg Leu Ser Glu 
            980                 985                 990         


Val Leu Asp Tyr Ile Asp Ala Pro  Asn Ala Thr Phe Asp  Leu Leu Ala 
        995                 1000                 1005             


Tyr Gln  Leu Asp Glu Tyr Asp  Arg Tyr Arg Val Glu  Ile Phe Gln 
    1010                 1015                 1020             


Gln Thr  Phe Asp Phe Glu Lys  Ala Ile Ala Ile Lys  His Leu Asp 
    1025                 1030                 1035             


Arg Val  Lys His Phe Asp Ser  Ile Asp Lys Ala Gly  Lys Lys Gly 
    1040                 1045                 1050             


Lys Ile  Ala Glu Val Ser Phe  Arg Val Tyr Leu Asp  Val Leu Lys 
    1055                 1060                 1065             


Glu Leu  Lys Ile Leu Ala Thr  Asp Glu Ala Asp Leu  Leu Lys Asn 
    1070                 1075                 1080             


Val Arg  Asn Lys Phe Ser His  Ser Glu Phe Pro Pro  Phe Ile Lys 
    1085                 1090                 1095             


Ser Leu  Thr Lys Ile Thr Ser  Glu Asn Ile Ala Ser  Phe Glu Ala 
    1100                 1105                 1110             


Asn Lys  Phe Thr Lys Asp Ala  Ile Ser Ala Leu Asp  Ile Ser Val 
    1115                 1120                 1125             


Pro Ser  Lys Ile Leu Asn Glu  Tyr Lys Ala Val Leu  Ser Lys Phe 
    1130                 1135                 1140             


Ser 
    


<210>  2002
<211>  1135
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2002

Met Asn Thr Val Pro Ala Ser Glu Asn Lys Gly Gln Ser Arg Thr Val 
1               5                   10                  15      


Glu Asp Asp Pro Gln Tyr Phe Gly Leu Tyr Leu Asn Leu Ala Arg Glu 
            20                  25                  30          


Asn Leu Ile Glu Val Glu Ser His Val Arg Ile Lys Phe Gly Lys Lys 
        35                  40                  45              


Lys Leu Asn Glu Glu Ser Leu Lys Gln Ser Leu Leu Cys Asp His Leu 
    50                  55                  60                  


Leu Ser Val Asp Arg Trp Thr Lys Val Tyr Gly His Ser Arg Arg Tyr 
65                  70                  75                  80  


Leu Pro Phe Leu His Tyr Phe Asp Pro Asp Ser Gln Ile Glu Lys Asp 
                85                  90                  95      


His Asp Ser Lys Thr Gly Val Asp Pro Asp Ser Ala Gln Arg Leu Ile 
            100                 105                 110         


Arg Glu Leu Tyr Ser Leu Leu Asp Phe Leu Arg Asn Asp Phe Ser His 
        115                 120                 125             


Asn Arg Leu Asp Gly Thr Thr Phe Glu His Leu Glu Val Ser Pro Asp 
    130                 135                 140                 


Ile Ser Ser Phe Ile Thr Gly Thr Tyr Ser Leu Ala Cys Gly Arg Ala 
145                 150                 155                 160 


Gln Ser Arg Phe Ala Asp Phe Phe Lys Pro Asp Asp Phe Val Leu Ala 
                165                 170                 175     


Lys Asn Arg Lys Glu Gln Leu Ile Ser Val Ala Asp Gly Lys Glu Cys 
            180                 185                 190         


Leu Thr Val Ser Gly Leu Ala Phe Phe Ile Cys Leu Phe Leu Asp Arg 
        195                 200                 205             


Glu Gln Ala Ser Gly Met Leu Ser Arg Ile Arg Gly Phe Lys Arg Thr 
    210                 215                 220                 


Asp Glu Asn Trp Ala Arg Ala Val His Glu Thr Phe Cys Asp Leu Cys 
225                 230                 235                 240 


Ile Arg His Pro His Asp Arg Leu Glu Ser Ser Asn Thr Lys Glu Ala 
                245                 250                 255     


Leu Leu Leu Asp Met Leu Asn Glu Leu Asn Arg Cys Pro Arg Ile Leu 
            260                 265                 270         


Tyr Asp Met Leu Pro Glu Glu Glu Arg Ala Gln Phe Leu Pro Ala Leu 
        275                 280                 285             


Asp Glu Asn Ser Met Asn Asn Leu Ser Glu Asn Ser Leu Asn Glu Glu 
    290                 295                 300                 


Ser Arg Leu Leu Trp Asp Gly Ser Ser Asp Trp Ala Glu Ala Leu Thr 
305                 310                 315                 320 


Lys Arg Ile Arg His Gln Asp Arg Phe Pro Tyr Leu Met Leu Arg Phe 
                325                 330                 335     


Ile Glu Glu Met Asp Leu Leu Lys Gly Ile Arg Phe Arg Val Asp Leu 
            340                 345                 350         


Gly Glu Ile Glu Leu Asp Ser Tyr Ser Lys Lys Val Gly Gln Asn Gly 
        355                 360                 365             


Glu Tyr Asp Arg Thr Ile Thr Asp Tyr Ala Leu Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Asp Phe Gln Asn Glu Glu Glu Val Ser Arg Met Ile Ser Gly Glu 
385                 390                 395                 400 


Ala Ser Tyr Pro Val Arg Phe Ser Leu Phe Ala Pro Arg Tyr Ala Ile 
                405                 410                 415     


Tyr Asp Asn Lys Ile Gly Tyr Cys His Thr Ser Asp Pro Val Tyr Pro 
            420                 425                 430         


Lys Ser Lys Thr Gly Glu Lys Arg Ala Leu Ser Asn Pro Gln Ser Met 
        435                 440                 445             


Gly Phe Ile Ser Val His Asp Leu Arg Lys Leu Leu Leu Met Glu Leu 
    450                 455                 460                 


Leu Cys Glu Gly Ser Phe Ser Arg Met Gln Ser Asp Phe Leu Arg Lys 
465                 470                 475                 480 


Ala Asn Arg Ile Leu Asp Glu Thr Ala Glu Gly Lys Leu Gln Phe Ser 
                485                 490                 495     


Ala Leu Phe Pro Glu Met Arg His Arg Phe Ile Pro Pro Gln Asn Pro 
            500                 505                 510         


Lys Ser Lys Asp Arg Arg Glu Lys Ala Glu Thr Thr Leu Glu Lys Tyr 
        515                 520                 525             


Lys Gln Glu Ile Lys Gly Arg Lys Asp Lys Leu Asn Ser Gln Leu Leu 
    530                 535                 540                 


Ser Ala Phe Asp Met Asp Gln Arg Gln Leu Pro Ser Arg Leu Leu Asp 
545                 550                 555                 560 


Glu Trp Met Asn Ile Arg Pro Ala Ser His Ser Val Lys Leu Arg Thr 
                565                 570                 575     


Tyr Val Lys Gln Leu Asn Glu Asp Cys Arg Leu Arg Leu Arg Lys Phe 
            580                 585                 590         


Arg Lys Asp Gly Asp Gly Lys Ala Arg Ala Ile Pro Leu Val Gly Glu 
        595                 600                 605             


Met Ala Thr Phe Leu Ser Gln Asp Ile Val Arg Met Ile Ile Ser Glu 
    610                 615                 620                 


Glu Thr Lys Lys Leu Ile Thr Ser Ala Tyr Tyr Asn Glu Met Gln Arg 
625                 630                 635                 640 


Ser Leu Ala Gln Tyr Ala Gly Glu Glu Asn Arg Arg Gln Phe Arg Ala 
                645                 650                 655     


Ile Val Ala Glu Leu His Leu Leu Asp Pro Ser Ser Gly His Pro Phe 
            660                 665                 670         


Leu Ser Ala Thr Met Glu Thr Ala His Arg Tyr Thr Glu Asp Phe Tyr 
        675                 680                 685             


Lys Cys Tyr Leu Glu Lys Lys Arg Glu Trp Leu Ala Lys Thr Phe Tyr 
    690                 695                 700                 


Arg Pro Glu Gln Asp Glu Asn Thr Lys Arg Arg Ile Ser Val Phe Phe 
705                 710                 715                 720 


Val Pro Asp Gly Glu Ala Arg Lys Leu Leu Pro Leu Leu Ile Arg Arg 
                725                 730                 735     


Arg Met Lys Glu Gln Asn Asp Leu Gln Asp Trp Ile Arg Asn Lys Gln 
            740                 745                 750         


Ala His Pro Ile Asp Leu Pro Ser His Leu Phe Asp Ser Lys Val Met 
        755                 760                 765             


Glu Leu Leu Lys Val Lys Asp Gly Lys Lys Lys Trp Asn Glu Ala Phe 
    770                 775                 780                 


Lys Asp Trp Trp Ser Thr Lys Tyr Pro Asp Gly Met Gln Pro Phe Tyr 
785                 790                 795                 800 


Gly Leu Arg Arg Glu Leu Asn Ile His Gly Lys Ser Val Ser Tyr Ile 
                805                 810                 815     


Pro Ser Asp Gly Lys Lys Phe Ala Asp Cys Tyr Thr His Leu Met Glu 
            820                 825                 830         


Lys Thr Val Arg Asp Lys Lys Arg Glu Leu Arg Thr Ala Gly Lys Pro 
        835                 840                 845             


Val Pro Pro Asp Leu Ala Ala Asp Ile Lys Arg Ser Phe His Arg Ala 
    850                 855                 860                 


Val Asn Glu Arg Glu Phe Met Leu Arg Leu Val Gln Glu Asp Asp Arg 
865                 870                 875                 880 


Leu Met Leu Met Ala Ile Asn Lys Met Met Thr Asp Arg Glu Glu Asp 
                885                 890                 895     


Ile Leu Pro Gly Leu Lys Asn Ile Asp Ser Ile Leu Asp Glu Glu Asn 
            900                 905                 910         


Gln Phe Ser Leu Ala Val His Ala Lys Val Leu Glu Lys Glu Gly Glu 
        915                 920                 925             


Gly Gly Asp Asn Ser Leu Ser Leu Val Pro Ala Thr Ile Val Ile Lys 
    930                 935                 940                 


Ser Lys Arg Lys Asp Trp Ser Lys Tyr Ile Arg Tyr Arg Tyr Asp Arg 
945                 950                 955                 960 


Arg Val Pro Gly Leu Met Ser His Phe Pro Glu His Lys Ala Thr Leu 
                965                 970                 975     


Asp Glu Val Lys Thr Leu Leu Gly Glu Tyr Asp Arg Cys Arg Ile Lys 
            980                 985                 990         


Ile Phe Asp Trp Ala Phe Ala Leu  Glu Gly Ala Ile Met  Ser Asp Arg 
        995                 1000                 1005             


Asp Leu  Lys Pro Tyr Leu His  Glu Ser Ser Ser Arg  Glu Gly Lys 
    1010                 1015                 1020             


Ser Gly  Glu His Ser Thr Leu  Val Lys Met Leu Val  Glu Lys Lys 
    1025                 1030                 1035             


Gly Cys  Leu Thr Pro Asp Glu  Ser Gln Tyr Leu Ile  Leu Ile Arg 
    1040                 1045                 1050             


Asn Lys  Ala Ala His Asn Gln  Phe Pro Cys Ala Ala  Glu Met Pro 
    1055                 1060                 1065             


Leu Ile  Tyr Arg Asp Val Ser  Ala Lys Val Gly Ser  Ile Glu Gly 
    1070                 1075                 1080             


Ser Ser  Ala Lys Asp Leu Pro  Glu Gly Ser Ser Leu  Val Asp Ser 
    1085                 1090                 1095             


Leu Trp  Lys Lys Tyr Glu Met  Ile Ile Arg Lys Ile  Leu Pro Ile 
    1100                 1105                 1110             


Leu Asp  Pro Glu Asn Arg Phe  Phe Gly Lys Leu Leu  Asn Asn Met 
    1115                 1120                 1125             


Ser Gln  Pro Ile Asn Asp Leu  
    1130                 1135 


<210>  2003
<211>  1175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2003

Met Thr Glu Gln Asn Glu Arg Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Thr His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Tyr Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Gly Thr Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Thr Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Phe Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Asp Glu Ala 
            500                 505                 510         


Ser Ala Glu Lys Leu Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Asp Glu Ile Asp Thr Leu Asp 
    530                 535                 540                 


Arg Leu Asp Ala Tyr Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Ile Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Gly Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly His Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Asp Leu Glu Ala Trp Ser Gln Ser Ala Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Ala Gly Ile Glu Asn Ala Ser Arg Glu Asn 
    850                 855                 860                 


Lys Lys Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Lys Ala 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Arg Gly Asp Lys Ile Asn Ile Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Ala Lys Glu His Pro Tyr His Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asp Ile Trp Thr 
945                 950                 955                 960 


Asp Val His Glu Gln Gly Ser Leu Asn Val Leu Asn Arg Val Lys Pro 
                965                 970                 975     


Met Arg Leu Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val 
            980                 985                 990         


His Lys Glu Gln Ala Pro Leu Ala  Thr Val Tyr Ile Glu  Glu Arg Asp 
        995                 1000                 1005             


Thr Lys  Leu Leu Lys Gln Gly  Asn Phe Lys Ser Phe  Val Lys Asp 
    1010                 1015                 1020             


Arg Arg  Leu Asn Gly Leu Phe  Ser Phe Val Asp Thr  Gly Ala Leu 
    1025                 1030                 1035             


Ala Met  Glu Gln Tyr Pro Ile  Ser Lys Leu Arg Val  Glu Tyr Glu 
    1040                 1045                 1050             


Leu Ala  Lys Tyr Gln Thr Ala  Arg Val Cys Ala Phe  Glu Gln Thr 
    1055                 1060                 1065             


Leu Glu  Leu Glu Glu Ser Leu  Leu Thr Arg Tyr Pro  His Leu Pro 
    1070                 1075                 1080             


Asp Lys  Asn Phe Arg Lys Met  Leu Glu Ser Trp Ser  Asp Pro Leu 
    1085                 1090                 1095             


Leu Asp  Lys Trp Pro Asp Leu  His Arg Lys Val Arg  Leu Leu Ile 
    1100                 1105                 1110             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1115                 1120                 1125             


Glu Ala  Val Phe Ser Ser Ile  Arg Lys Tyr Asp Pro  Ser Ser Pro 
    1130                 1135                 1140             


Asp Ala  Ile Glu Glu Arg Met  Gly Leu Asn Ile Ala  His Arg Leu 
    1145                 1150                 1155             


Ser Glu  Glu Val Lys Gln Ala  Lys Glu Met Ala Glu  Arg Ile Ile 
    1160                 1165                 1170             


Gln Ala  
    1175 


<210>  2004
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2004

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2005
<211>  1144
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2005

Met Asp Ile Ile Pro Lys Leu Thr Tyr Thr Ile Glu Ser Thr Pro Trp 
1               5                   10                  15      


Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg His Asn Val Tyr Leu Leu 
            20                  25                  30          


Ile Asn His Leu Thr Glu Lys Phe Ser His Leu Lys Tyr Glu Lys Leu 
        35                  40                  45              


Lys Asp Asp Lys Glu Ile Lys Gly Lys Asn Ile Leu Thr Glu Ile Phe 
    50                  55                  60                  


Asp Thr Thr Lys Ser Asp Leu Asp Glu Glu Arg Phe Arg Ile Tyr Lys 
65                  70                  75                  80  


Tyr Leu Val Arg Gly His Tyr Leu Pro Phe Ile Lys Val Tyr Ser Asp 
                85                  90                  95      


Ser Lys Gly Asn Ala Leu Glu Asn Asn Pro Leu Val Tyr Tyr Asp Arg 
            100                 105                 110         


Leu His Gln Phe Ile Asn Asn Ser Phe Ala Leu Leu Val Lys Phe Arg 
        115                 120                 125             


Asp Ala Phe Ser His Tyr Leu Ala Leu Asp Glu His Gly Asn Ser Ile 
    130                 135                 140                 


Asp Ser Arg Gln Leu Asn Ile Asp His Glu Ile Ala His Asp Leu Glu 
145                 150                 155                 160 


Thr Ile Phe Gln Asp Ser Leu Ser Leu Ser Ala Ser Arg Phe Tyr Leu 
                165                 170                 175     


Thr Gln Gln Glu Ser Asp Phe Glu His Leu Lys His Tyr Ala Leu Phe 
            180                 185                 190         


Lys Glu Thr Glu Thr Lys Leu Ser Glu Asn Gly Phe Tyr Phe Phe Ile 
        195                 200                 205             


Cys Leu Phe Leu Glu Lys Gln Tyr Ala Ile Lys Phe Leu Lys Lys Ile 
    210                 215                 220                 


Lys Gly Phe Lys Asn Glu Thr Ile Pro Ala Phe Arg Ala Thr Leu Leu 
225                 230                 235                 240 


Ala Phe Thr His Tyr Thr Ile Arg Ile Pro Asp Ile Arg Leu Asp Asn 
                245                 250                 255     


Asp Glu Pro Arg Met Gly Val Leu Met Glu Met Leu Asn Glu Leu Gln 
            260                 265                 270         


Lys Cys Pro Ile Glu Leu Tyr Lys Arg Leu Thr Asp Glu Asp Lys Lys 
        275                 280                 285             


Lys Phe Glu Pro Ala Leu Asp Glu Glu Ser Gln Leu Asn Leu Ile Leu 
    290                 295                 300                 


Asn Ser Thr Ala Asn Ser Glu Asn Leu Ser Asp Glu Gln Thr Asp Ser 
305                 310                 315                 320 


Leu Leu Ile Asp Leu Thr Thr Leu Lys Arg His Gln Asn Arg Phe Ser 
                325                 330                 335     


Tyr Phe Ala Leu Arg Cys Ile Asp Glu Leu Asn Leu Leu Pro Gly Ile 
            340                 345                 350         


His Phe Gln Ile Thr Val Gly Lys Ile Glu Leu Arg Ala Tyr Pro Lys 
        355                 360                 365             


Val Ile Gly Lys Val Ala Thr Asn Arg Arg Ile Leu Lys Glu Val Asn 
    370                 375                 380                 


Ala Phe Gly Lys Leu Ser Ala Tyr Glu Gly Lys Glu Asn Trp Phe Ser 
385                 390                 395                 400 


Gln Gln Leu Lys Met Ile Tyr Glu Asp Glu Asn Leu Val Phe Asp Gln 
                405                 410                 415     


Tyr Asn Pro His Tyr Asn Ile Gln Glu Asn Lys Ile Ala Phe Tyr Val 
            420                 425                 430         


Leu Asp Ser Gly Thr Ser Gly Thr Leu Leu Pro Leu Lys Lys Lys Asn 
        435                 440                 445             


Thr Leu Pro Thr Gly Phe Leu Ser Leu Asn Asp Leu Pro Lys Leu Ile 
    450                 455                 460                 


Val Arg Ala Leu Asn Ser Pro Gly Arg Thr Val Ser Leu Ile Lys Asp 
465                 470                 475                 480 


Phe Ile Ala Lys Asn Glu Asn Ile Ile Leu Asn Glu Asp Ala Leu Val 
                485                 490                 495     


Ala Trp Lys Glu Gln Leu His Leu Asp Pro Ala Val Phe Thr Arg Arg 
            500                 505                 510         


Ile Ile Lys Glu Asn Ala Leu Arg Gly Lys Glu Gly Ile Ala Tyr Leu 
        515                 520                 525             


Thr Gln Arg Lys Thr Asp Ala Leu Phe Lys Arg Tyr Lys Ala Leu Ser 
    530                 535                 540                 


Ile Lys Ile Asp Ser Leu Ala Gly Leu Lys Lys Leu Ile Asp Gln Leu 
545                 550                 555                 560 


His Ser Lys Lys Asp Lys Glu Tyr Ile Ser Gln Ile Val Tyr Thr His 
                565                 570                 575     


Phe Leu Asn Lys Arg Lys Asp Ala Leu Ala Gly Ile Leu Pro Lys Gly 
            580                 585                 590         


Leu Pro Val Asn Gln Leu Pro Leu Lys Val Ile Asn Tyr Leu Leu Ser 
        595                 600                 605             


Leu Glu Thr Val Gly His Lys Lys Lys Phe Leu His Tyr Ile Lys Glu 
    610                 615                 620                 


Glu Lys Arg Thr Cys Lys Thr Arg Leu Lys Ala Leu Asn Lys Gln Glu 
625                 630                 635                 640 


Asn Asn Ala Pro Lys Ile Gly Glu Ile Ala Thr Phe Leu Ala Arg Asp 
                645                 650                 655     


Ile Ile Asn Met Val Val Asn Glu Glu Thr Lys Gln Asn Ile Thr Ser 
            660                 665                 670         


Ala Tyr Tyr Asn Arg Leu Gln Asn Lys Ile Ala Tyr Phe Ser Ile Ser 
        675                 680                 685             


Lys Pro Glu Ile Ala Glu Met Leu Thr Glu Leu Asn Leu Phe Asp Lys 
    690                 695                 700                 


Lys Thr Gly His Pro Phe Leu Asp Lys Gly Ser Ile Met Ala Ser Ser 
705                 710                 715                 720 


Gly Ile Leu Ala Phe Tyr Glu Tyr Tyr Leu Val Glu Lys Ala Ala Trp 
                725                 730                 735     


Ile Asp Lys Gln Ile Leu His Lys Asn Gln Leu Lys Lys Asp Leu Glu 
            740                 745                 750         


Ser His Leu Asn Lys Leu Pro Phe Ala Tyr Ala Arg Arg Tyr Gln Lys 
        755                 760                 765             


Asn Asn Glu Val Asn Phe Thr Lys Trp Leu Ile Asn Lys Lys Val Met 
    770                 775                 780                 


Pro Val Asn Ile Pro Asn Asn Leu Phe Asp Ala Asp Val Asn Lys Ile 
785                 790                 795                 800 


Leu Lys Asp Ser Leu Arg Lys Met Gly Ile Ala Phe Lys Asp Thr Glu 
                805                 810                 815     


Lys Phe Ala Leu Leu Leu Ser Lys Ser Met Met Gly Asp Thr Gln Pro 
            820                 825                 830         


Phe Tyr Thr Tyr Lys Arg Glu Tyr Thr Val Asp Gly Glu Lys Ile Pro 
        835                 840                 845             


Phe Tyr Pro Ala Asn Gln Ser Gly Lys Asp Ile Lys Thr Asp Tyr Gly 
    850                 855                 860                 


Lys His Ala Asp Ala Ser Glu Lys Glu Ile Arg Phe Ile Gln Thr Gln 
865                 870                 875                 880 


Asp Arg Val Ile Lys Leu Leu Cys Arg Asn Ile Ile Gln Ser Ile Val 
                885                 890                 895     


Lys Phe Lys Glu Ser Asn Leu Asp Ile Ile Leu Asn Asn Ile Tyr Pro 
            900                 905                 910         


Phe Ser Glu Thr Ser Val Leu Asn Ala Pro Gln Lys Phe Glu Phe Thr 
        915                 920                 925             


Leu Pro Lys Asn Gly Lys Lys Lys Ile Ile Val Ala Glu Asp Thr Ser 
    930                 935                 940                 


Ala Gln Lys Glu Gln Val Leu Arg Tyr Lys Gly Leu Ser Asp Leu Glu 
945                 950                 955                 960 


Glu Arg Lys Gln Tyr Asn Gly Gln Lys Gly Tyr Gln Trp Thr Ile Lys 
                965                 970                 975     


Asp Phe Gly Arg Phe Lys Arg Phe Val His Asp Arg Arg Leu Ser Glu 
            980                 985                 990         


Val Leu Asp Tyr Ile Asp Ala Pro  Asn Ala Thr Phe Asp  Leu Leu Ala 
        995                 1000                 1005             


Tyr Gln  Leu Asp Glu Tyr Asp  Arg Tyr Arg Val Glu  Ile Phe Gln 
    1010                 1015                 1020             


Gln Thr  Phe Asp Phe Glu Lys  Ala Ile Ala Ile Lys  His Leu Asp 
    1025                 1030                 1035             


Arg Val  Lys His Phe Asp Ser  Ile Asp Lys Ala Gly  Lys Lys Gly 
    1040                 1045                 1050             


Lys Ile  Ala Glu Val Ser Phe  Arg Val Tyr Leu Asp  Val Leu Lys 
    1055                 1060                 1065             


Glu Leu  Lys Ile Leu Ala Thr  Asp Glu Ala Asp Leu  Leu Lys Asn 
    1070                 1075                 1080             


Val Arg  Asn Lys Phe Ser His  Ser Glu Phe Pro Pro  Phe Ile Lys 
    1085                 1090                 1095             


Ser Leu  Thr Lys Ile Thr Ser  Glu Asn Ile Ala Ser  Phe Glu Ala 
    1100                 1105                 1110             


Asn Lys  Phe Thr Lys Asp Ala  Ile Ser Ala Leu Asp  Ile Ser Val 
    1115                 1120                 1125             


Pro Ser  Lys Ile Leu Asn Glu  Tyr Lys Ala Val Leu  Ser Lys Phe 
    1130                 1135                 1140             


Ser 
    


<210>  2006
<211>  1175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2006

Met Thr Glu Gln Asn Glu Lys Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Thr His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Phe Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Lys Tyr Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Gly Lys Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Thr Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Ala 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Phe Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Glu Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Asp Glu Ile Asn Thr Arg Asp 
    530                 535                 540                 


Glu Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Lys His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Gly Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Leu Asp Glu Val Arg Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Ser Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Asp Leu Glu Ala Trp Ser His Ser Ala Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Ala Gly Ile Glu Asn Ala Ser Arg Glu Asn 
    850                 855                 860                 


Lys Lys Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Glu Thr 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Lys Ala Asp Lys Ile Asn Ile Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Ala Lys Glu His Pro Tyr Leu Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asp Ile Arg Thr 
945                 950                 955                 960 


Asp Val Gln Glu Gln Gly Ser Leu Asn Val Leu Asn His Val Lys Pro 
                965                 970                 975     


Met Arg Leu Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val 
            980                 985                 990         


His Lys Glu Gln Ala Pro Leu Ala  Thr Val Tyr Ile Glu  Glu Arg Asp 
        995                 1000                 1005             


Thr Lys  Leu Leu Lys Gln Gly  Asn Phe Lys Ser Phe  Val Lys Asp 
    1010                 1015                 1020             


Arg Arg  Leu Asn Gly Leu Phe  Ser Phe Val Asp Thr  Gly Gly Leu 
    1025                 1030                 1035             


Ala Met  Glu Gln Tyr Pro Ile  Ser Lys Leu Arg Val  Glu Tyr Glu 
    1040                 1045                 1050             


Leu Ala  Lys Tyr Gln Thr Ala  Arg Val Cys Ala Phe  Glu Gln Thr 
    1055                 1060                 1065             


Leu Glu  Leu Glu Glu Ser Leu  Leu Thr Arg Tyr Pro  His Leu Pro 
    1070                 1075                 1080             


Asp Lys  Asn Phe Arg Lys Met  Leu Glu Ser Trp Ser  Asp Pro Leu 
    1085                 1090                 1095             


Leu Ala  Lys Trp Pro Glu Leu  His Glu Lys Val Arg  Leu Leu Ile 
    1100                 1105                 1110             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1115                 1120                 1125             


Glu Ala  Val Phe Ser Pro Ile  Arg Lys Tyr Asp Pro  Ser Ser Pro 
    1130                 1135                 1140             


Asp Ala  Ile Glu Glu Arg Met  Arg Leu Asn Ile Ala  His Arg Leu 
    1145                 1150                 1155             


Ser Glu  Glu Val Lys Gln Ala  Lys Glu Thr Val Glu  Arg Ile Ile 
    1160                 1165                 1170             


Gln Ala  
    1175 


<210>  2007
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2007

Met Gly Ala Ile Lys Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Gly Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2008
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2008

Met Asn Thr His Gln Glu Glu Leu Gln Ser Trp Ile Thr Arg Lys Arg 
1               5                   10                  15      


Leu Pro Asp Thr Glu Met Lys Lys Tyr Trp Ala Ala Tyr Met Asn Leu 
            20                  25                  30          


Ala Arg Leu Asn Phe Phe Lys Thr Leu Met Phe Ile Ser Asn Ser Ile 
        35                  40                  45              


Gly Asp Leu Lys Pro Ala Lys Asp Asn Asn Gly Lys Gly Asn Thr Glu 
    50                  55                  60                  


Val Asn Met His Asn Met Gly Ile Leu Thr Ala Leu Leu Gly Pro Glu 
65                  70                  75                  80  


Asp Glu Glu Lys Ala Arg Leu Leu Ile Phe Lys His Phe Pro Phe Leu 
                85                  90                  95      


Arg Thr Phe Cys Ile Glu Lys Glu Leu Ser Leu Ser Lys Gln Arg Thr 
            100                 105                 110         


Ile Leu Ile Asp Met Ala Cys Ile Ile Gly Arg Tyr Arg Asn Met Tyr 
        115                 120                 125             


Ser His Ser Ile Phe Ile Ser Asp Asp Asn Glu Lys Val Leu Glu Ser 
    130                 135                 140                 


Glu Lys Arg Cys Ser Glu Tyr Leu Gln Ser Ile Leu Thr Val Ser Thr 
145                 150                 155                 160 


Arg Ile Ile Lys Glu Arg Tyr Arg Ser Asn Lys Asn Asp Ala Gln Arg 
                165                 170                 175     


Gly Met Ile Asp Asp Lys Ser Leu Lys Phe Ile Ser Glu Asn Lys Val 
            180                 185                 190         


Lys Phe Val Tyr Asp Glu Asn Gly Lys Arg Ile Thr Ala Pro Asn Lys 
        195                 200                 205             


Lys Tyr Tyr Leu Ser Thr Ile Asp Lys Asp Asn Thr His Leu Ser Tyr 
    210                 215                 220                 


Phe Gly Lys Leu Met Leu Thr Cys Ile Leu Leu Glu Lys Lys Tyr Ala 
225                 230                 235                 240 


Thr Asp Phe Leu Thr Gln Cys His Phe Leu Asp Ala Phe Asn Asp Ser 
                245                 250                 255     


Glu Val Ala Pro Lys Leu Ser Glu Arg Arg Leu Met Leu Glu Val Met 
            260                 265                 270         


Thr Ala Leu Arg Ile Arg Leu Ala Glu Lys Lys Leu Ser Asn Glu Lys 
        275                 280                 285             


Ser Glu Val Gln Ile Ser Leu Asp Ile Leu Asn Glu Leu Lys Lys Cys 
    290                 295                 300                 


Pro Phe Glu Leu Tyr Glu Leu Leu Gly Ser Glu Asp Lys Arg Leu Phe 
305                 310                 315                 320 


Thr Ile Val Ala Asp Thr Gly Glu Thr Ile Leu Leu Arg Arg His Glu 
                325                 330                 335     


Asp Arg Phe Pro Gln Leu Ala Leu Ser Trp Ile Asp Ser Ser Lys Ala 
            340                 345                 350         


Phe Asp His Leu Arg Phe Gln Val Asn Ala Gly Lys Leu Arg Tyr Leu 
        355                 360                 365             


Phe Arg Asp Asn Lys His Cys Ile Asp Gly Gln Thr Arg Met Arg Val 
    370                 375                 380                 


Leu Glu Glu Pro Leu Asn Gly Tyr Arg Arg Leu Met Glu Phe Glu Glu 
385                 390                 395                 400 


Glu Arg Ile Gln Lys Gln Ser Gly Glu Ile Arg Ser Leu Trp Pro Gly 
                405                 410                 415     


Leu Asp Ile Leu Asn Lys Asp Glu Thr Pro Arg Asn Asp Ala Ser Val 
            420                 425                 430         


Leu Pro Tyr Ile Ser Asp Tyr Arg Val Arg Tyr Leu Phe Asp Gly Asp 
        435                 440                 445             


Asn Ile Gly Ile Ser Ile Gly Asp Phe Thr Pro Ser Ile Thr Lys Thr 
    450                 455                 460                 


Asp Glu Thr Lys Tyr Arg Val Thr Gly Lys Thr Ala Asp Cys Cys Leu 
465                 470                 475                 480 


Ser Lys Tyr Glu Leu Pro Gly Leu Leu Phe Tyr His Leu Leu Thr Leu 
                485                 490                 495     


Arg His Gly Asp Asn Lys Arg Ser Thr Lys Asn Ala Glu Asp Ile Ile 
            500                 505                 510         


Ile Asp Ala Ile Lys Arg Tyr Lys Arg Leu Phe Ser Asp Val Lys Glu 
        515                 520                 525             


Gly Ile Leu Lys Pro Ile Lys Glu Glu Asn Ala Asn Gln Leu Gly Asn 
    530                 535                 540                 


Arg Ile Trp Asn Ser Tyr Gly Ile Asn Ile Lys Asp Ile Pro Asp Lys 
545                 550                 555                 560 


Ile Ile Asp Tyr Leu Leu Val Arg Glu Cys Asn Glu Asp Glu Lys Phe 
                565                 570                 575     


Thr Ala Trp Lys Asn Gly Phe Ile Ser Glu Met Leu Gln Ser Thr Lys 
            580                 585                 590         


Asn Arg Ile Lys Arg Phe Glu Lys Asp Ser Glu Ala Val Ile Ser Ser 
        595                 600                 605             


Asp Asn Lys Pro Gly Lys Lys Asn His Val Ser Leu Lys Pro Gly Ala 
    610                 615                 620                 


Tyr Ala Ser Phe Ile Ala Asn Asp Ile Val Phe Phe Gln Glu Cys Gly 
625                 630                 635                 640 


Ala Thr Glu Lys Met Thr Gly Leu Asn Phe Lys Val Met Gln Ser Arg 
                645                 650                 655     


Leu Ala Thr Phe Thr Lys Asp Gly Ser Thr Ser Phe Asn Ile Leu Leu 
            660                 665                 670         


Gln Thr Leu Lys Asn Ala His Leu Val Ser Thr Thr Tyr Gly Lys Gly 
        675                 680                 685             


Asp His Pro Phe Leu Tyr Arg Val Ile Lys Gln Gln Pro Ser Asp Ile 
    690                 695                 700                 


Val Gln Phe Tyr Lys Ile Tyr Leu Asn Glu Lys Val Leu Tyr Leu Gln 
705                 710                 715                 720 


Ser Asp Ile Pro Asp Asn Ala Ile Phe Leu His Gly Glu Arg Lys Arg 
                725                 730                 735     


Trp Glu Asn Arg Asn Glu Gln Tyr Tyr Arg Asp Leu Ala Glu Arg Tyr 
            740                 745                 750         


Leu Gln Arg Pro Ile Gln Leu Pro Arg Gln Leu Phe Glu Ser His Ile 
        755                 760                 765             


Arg Gln Leu Leu Leu Ser Asp Cys Ile Lys Gly Glu Arg Gly Asn Asp 
    770                 775                 780                 


Leu Lys Glu Ala Ile Asn Ser Ala Ala Ser Gln Gly Arg Cys Asn Thr 
785                 790                 795                 800 


Thr Tyr Met Ile Met Glu Tyr Phe Ala Asp Tyr Leu Cys Asp Gly Thr 
                805                 810                 815     


Gln Phe Phe Tyr Gly Leu Phe Asp Gly Asp Leu Ser His Glu Tyr Asn 
            820                 825                 830         


Tyr Arg Phe Tyr Ser Leu Ile Ser Asn Asn Ile Glu Asn Ser Lys Lys 
        835                 840                 845             


Leu Val Leu Thr Leu Lys Lys Gly Asn Asn Ser Lys Glu Ser Pro Phe 
    850                 855                 860                 


Ile Ser Ala Leu Glu Arg Gly Ile His Trp Ser Lys Met Asn Pro Leu 
865                 870                 875                 880 


Met Lys Lys Gly Leu Lys Asn Asp Ser Ser Glu Gly Asp Phe Val His 
                885                 890                 895     


Ala Ala Lys Arg Ala Tyr Lys Glu Met Thr Glu Thr Glu Arg Met Phe 
            900                 905                 910         


Arg Arg Tyr Ala Val Gln Asp Glu Val Leu Phe Leu Ala Ala Lys Ile 
        915                 920                 925             


Thr Ile Arg Arg Val Leu Gly Leu Ser Glu Gln Tyr Asn Cys Leu Leu 
    930                 935                 940                 


Gly Asp Ile Lys Pro Gln Gly Gly Ser Leu Leu Glu Gln Thr Ile Pro 
945                 950                 955                 960 


Ser Ile Thr Thr Lys His Thr Ile Asn Thr Gly Asn Lys Lys Gln Lys 
                965                 970                 975     


Pro Lys Gln Val Gln Ile Leu Gln Lys Asn Val Lys Leu Lys Asp Phe 
            980                 985                 990         


Gly Lys Val Phe Lys Leu Leu Asn  Asp Arg Arg Ile Phe  Asp Leu Leu 
        995                 1000                 1005             


Phe Asn  Lys Gly Asn Glu Ala  Val Ser Met Thr Asp  Leu Cys Glu 
    1010                 1015                 1020             


Glu Leu  Glu Arg Tyr Asp Arg  His Arg Val Asp Val  Phe Asp Ser 
    1025                 1030                 1035             


Val Leu  Lys Tyr Glu Ser Lys  Ile Thr Lys Gly Tyr  Thr Asn Lys 
    1040                 1045                 1050             


Glu Leu  Met Asn Glu Ser Gly  Gln Ile Asp Phe Lys  Ala Ile Gln 
    1055                 1060                 1065             


Ala Phe  Asp Lys Gln Asn Thr  Thr Ala Asp Lys Glu  Asp Leu Arg 
    1070                 1075                 1080             


Leu Ile  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Gln Tyr Asn 
    1085                 1090                 1095             


Asn Glu  Pro Ile Leu Phe Asp  Lys Asp Ile Pro Glu  Ile Ala Asp 
    1100                 1105                 1110             


Glu Ile  Ser Ile Ile Ala Lys  Asp Ile Glu Glu Asn  Thr Lys 
    1115                 1120                 1125         


<210>  2009
<211>  1144
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2009

Met Asp Ile Ile Pro Lys Leu Thr Tyr Thr Ile Glu Ser Thr Pro Trp 
1               5                   10                  15      


Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg His Asn Val Tyr Leu Leu 
            20                  25                  30          


Ile Asn His Leu Thr Glu Lys Phe Ser His Leu Lys Tyr Glu Lys Leu 
        35                  40                  45              


Lys Asp Asp Lys Glu Ile Lys Gly Lys Asn Ile Leu Thr Glu Ile Phe 
    50                  55                  60                  


Asp Thr Thr Lys Ser Asp Leu Asp Glu Glu Arg Phe Arg Ile Tyr Lys 
65                  70                  75                  80  


Tyr Leu Val Arg Gly His Tyr Leu Pro Phe Ile Lys Val Tyr Ser Asp 
                85                  90                  95      


Ser Lys Gly Asn Ala Leu Glu Asn Asn Pro Leu Val Tyr Tyr Asp Arg 
            100                 105                 110         


Leu His Gln Phe Ile Asn Asn Ser Phe Ala Leu Leu Val Lys Phe Arg 
        115                 120                 125             


Asp Ala Phe Ser His Tyr Leu Ala Leu Asp Glu His Gly Asn Ser Ile 
    130                 135                 140                 


Asp Ser Arg Gln Leu Asn Ile Asp His Glu Ile Ala His Asp Leu Glu 
145                 150                 155                 160 


Thr Ile Phe Gln Asp Ser Leu Ser Leu Ser Ala Ser Arg Phe Tyr Leu 
                165                 170                 175     


Thr Gln Gln Glu Ser Asp Phe Glu His Leu Lys His Tyr Ala Leu Phe 
            180                 185                 190         


Lys Glu Thr Glu Thr Lys Leu Ser Glu Asn Gly Phe Tyr Phe Phe Ile 
        195                 200                 205             


Cys Leu Phe Leu Glu Lys Gln Tyr Ala Ile Lys Phe Leu Lys Lys Ile 
    210                 215                 220                 


Lys Gly Phe Lys Asn Glu Thr Ile Pro Ala Phe Arg Ala Thr Leu Leu 
225                 230                 235                 240 


Ala Phe Thr His Tyr Thr Ile Arg Ile Pro Asp Ile Arg Leu Asp Asn 
                245                 250                 255     


Asp Glu Pro Arg Met Gly Val Leu Met Glu Met Leu Asn Glu Leu Gln 
            260                 265                 270         


Lys Cys Pro Ile Glu Leu Tyr Lys Arg Leu Thr Asp Glu Asp Lys Lys 
        275                 280                 285             


Lys Phe Glu Pro Ala Leu Asp Glu Glu Ser Gln Leu Asn Leu Ile Leu 
    290                 295                 300                 


Asn Ser Thr Ala Asn Ser Glu Asn Leu Ser Asp Glu Gln Thr Asp Ser 
305                 310                 315                 320 


Leu Leu Ile Asp Leu Thr Thr Leu Lys Arg His Gln Asn Arg Phe Ser 
                325                 330                 335     


Tyr Phe Ala Leu Arg Cys Ile Asp Glu Leu Asn Leu Leu Pro Gly Ile 
            340                 345                 350         


His Phe Gln Ile Thr Val Gly Lys Ile Glu Leu Arg Ala Tyr Pro Lys 
        355                 360                 365             


Val Ile Gly Lys Val Ala Thr Asn Arg Arg Ile Leu Lys Glu Val Asn 
    370                 375                 380                 


Ala Phe Gly Lys Leu Ser Ala Tyr Glu Gly Lys Glu Asn Trp Phe Ser 
385                 390                 395                 400 


Gln Gln Leu Lys Met Ile Tyr Glu Asp Glu Asn Leu Val Phe Asp Gln 
                405                 410                 415     


Tyr Asn Pro His Tyr Asn Ile Gln Glu Asn Lys Ile Ala Phe Tyr Val 
            420                 425                 430         


Leu Asp Ser Gly Thr Ser Gly Thr Leu Leu Pro Leu Lys Lys Lys Asn 
        435                 440                 445             


Thr Leu Pro Thr Gly Phe Leu Ser Leu Asn Asp Leu Pro Lys Leu Ile 
    450                 455                 460                 


Val Arg Ala Leu Asn Ser Pro Gly Arg Thr Val Ser Leu Ile Lys Asp 
465                 470                 475                 480 


Phe Ile Ala Lys Asn Glu Asn Ile Ile Leu Asn Glu Asp Ala Leu Val 
                485                 490                 495     


Ala Trp Lys Glu Gln Leu His Leu Asp Pro Ala Val Phe Thr Arg Arg 
            500                 505                 510         


Ile Ile Lys Glu Asn Ala Leu Arg Gly Lys Glu Gly Ile Ala Tyr Leu 
        515                 520                 525             


Thr Gln Arg Lys Thr Asp Ala Leu Phe Lys Arg Tyr Lys Ala Leu Ser 
    530                 535                 540                 


Ile Lys Ile Asp Ser Leu Ala Gly Leu Lys Lys Leu Ile Asp Gln Leu 
545                 550                 555                 560 


His Ser Lys Lys Asp Lys Glu Tyr Ile Ser Gln Ile Val Tyr Thr His 
                565                 570                 575     


Phe Leu Asn Lys Arg Lys Asp Ala Leu Ala Gly Ile Leu Pro Lys Gly 
            580                 585                 590         


Leu Pro Val Asn Gln Leu Pro Leu Lys Val Ile Asn Tyr Leu Leu Ser 
        595                 600                 605             


Leu Glu Thr Val Gly His Lys Lys Lys Phe Leu His Tyr Ile Lys Glu 
    610                 615                 620                 


Glu Lys Arg Thr Cys Lys Thr Arg Leu Lys Ala Leu Asn Lys Gln Glu 
625                 630                 635                 640 


Asn Asn Ala Pro Lys Ile Gly Glu Ile Ala Thr Phe Leu Ala Arg Asp 
                645                 650                 655     


Ile Ile Asn Met Val Val Asn Glu Glu Thr Lys Gln Asn Ile Thr Ser 
            660                 665                 670         


Ala Tyr Tyr Asn Arg Leu Gln Asn Lys Ile Ala Tyr Phe Ser Ile Ser 
        675                 680                 685             


Lys Pro Glu Ile Ala Glu Met Leu Thr Glu Leu Asn Leu Phe Asp Lys 
    690                 695                 700                 


Lys Thr Gly His Pro Phe Leu Asp Lys Gly Ser Ile Met Ala Ser Ser 
705                 710                 715                 720 


Gly Ile Leu Ala Phe Tyr Glu Tyr Tyr Leu Val Glu Lys Ala Ala Trp 
                725                 730                 735     


Ile Asp Lys Gln Ile Leu His Lys Asn Gln Leu Lys Lys Asp Leu Glu 
            740                 745                 750         


Ser His Leu Asn Lys Leu Pro Phe Ala Tyr Ala Arg Arg Tyr Gln Lys 
        755                 760                 765             


Asn Asn Glu Val Asn Phe Thr Lys Trp Leu Ile Asn Lys Lys Val Met 
    770                 775                 780                 


Pro Val Asn Ile Pro Asn Asn Leu Phe Asp Ala Asp Val Asn Lys Ile 
785                 790                 795                 800 


Leu Lys Asp Ser Leu Arg Lys Met Gly Ile Ala Phe Lys Asp Thr Glu 
                805                 810                 815     


Lys Phe Ala Leu Leu Leu Ser Lys Ser Met Met Gly Asp Thr Gln Pro 
            820                 825                 830         


Phe Tyr Thr Tyr Lys Arg Glu Tyr Thr Val Asp Gly Glu Lys Ile Pro 
        835                 840                 845             


Phe Tyr Pro Ala Asn Gln Ser Gly Lys Asp Ile Lys Thr Asp Tyr Gly 
    850                 855                 860                 


Lys His Ala Asp Ala Ser Glu Lys Glu Ile Arg Phe Ile Gln Thr Gln 
865                 870                 875                 880 


Asp Arg Val Ile Lys Leu Leu Cys Arg Asn Ile Ile Gln Ser Ile Val 
                885                 890                 895     


Lys Phe Lys Glu Ser Asn Leu Asp Ile Ile Leu Asn Asn Ile Tyr Pro 
            900                 905                 910         


Phe Ser Glu Thr Ser Val Leu Asn Ala Pro Gln Lys Phe Glu Phe Thr 
        915                 920                 925             


Leu Pro Lys Asn Gly Lys Lys Lys Ile Ile Val Ala Glu Asp Thr Ser 
    930                 935                 940                 


Ala Gln Lys Glu Gln Val Leu Arg Tyr Lys Gly Leu Ser Asp Leu Glu 
945                 950                 955                 960 


Glu Arg Lys Gln Tyr Asn Gly Gln Lys Gly Tyr Gln Trp Thr Ile Lys 
                965                 970                 975     


Asp Phe Gly Arg Phe Lys Arg Phe Val His Asp Arg Arg Leu Ser Glu 
            980                 985                 990         


Val Leu Asp Tyr Ile Asp Ala Pro  Asn Ala Thr Phe Asp  Leu Leu Ala 
        995                 1000                 1005             


Tyr Gln  Leu Asp Glu Tyr Asp  Arg Tyr Arg Val Glu  Ile Phe Gln 
    1010                 1015                 1020             


Gln Thr  Phe Asp Phe Glu Lys  Ala Ile Ala Ile Lys  His Leu Asp 
    1025                 1030                 1035             


Arg Val  Lys His Phe Asp Ser  Ile Asp Lys Ala Gly  Lys Lys Gly 
    1040                 1045                 1050             


Lys Ile  Ala Glu Val Ser Phe  Arg Val Tyr Leu Asp  Val Leu Lys 
    1055                 1060                 1065             


Glu Leu  Lys Ile Leu Ala Thr  Asp Glu Ala Asp Leu  Leu Lys Asn 
    1070                 1075                 1080             


Val Arg  Asn Lys Phe Ser His  Ser Glu Phe Pro Pro  Phe Ile Lys 
    1085                 1090                 1095             


Ser Leu  Thr Lys Ile Thr Ser  Glu Asn Ile Ala Ser  Phe Glu Ala 
    1100                 1105                 1110             


Asn Lys  Phe Thr Lys Asp Ala  Ile Ser Ala Leu Asp  Ile Ser Val 
    1115                 1120                 1125             


Pro Ser  Lys Ile Leu Asn Glu  Tyr Lys Ala Val Leu  Ser Lys Phe 
    1130                 1135                 1140             


Ser 
    


<210>  2010
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2010

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2011
<211>  1134
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2011

Met Asn Glu Thr Asp Tyr Leu Ala Lys Arg Leu Glu Tyr Asn Tyr Ala 
1               5                   10                  15      


Ser Ile Glu Asp Lys His Tyr Phe Gly Gly Tyr Phe Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asn Asp Leu Ser Lys Ala Phe Lys Glu Lys Phe Gly Met 
        35                  40                  45              


Lys Pro Lys Ser Cys Ile Leu Asp Phe Phe Thr Gln Asp Lys Ala Ile 
    50                  55                  60                  


Ala Glu Tyr Gln Leu Gly Val Glu Phe Leu Gln Lys Asn Leu Pro Val 
65                  70                  75                  80  


Ile Arg Tyr Leu Tyr Leu Pro Thr Ser His Lys Arg Phe Glu Asn Val 
                85                  90                  95      


Pro Lys Asn Gln Leu Ile Ser Glu Gln Arg Asn Tyr Phe Lys Asn Ser 
            100                 105                 110         


Leu Lys Val Leu Lys Asn Leu Ile Arg Asp Tyr Arg Asn Phe Tyr Thr 
        115                 120                 125             


His His Phe His Lys Pro Ile Pro Val Phe Pro Glu Thr Tyr Lys Leu 
    130                 135                 140                 


Leu Asp Asp Leu Phe Leu Ala Val Ala Asn Asp Val Lys Lys His Arg 
145                 150                 155                 160 


Met Lys Thr Asp Ala Ser Lys Gln Leu Leu Lys Lys Gly Leu Ile Glu 
                165                 170                 175     


Glu Leu Ala Gln Leu Glu Lys Leu Lys Leu Glu Asp Leu Lys Lys Leu 
            180                 185                 190         


Lys Arg Glu Gly Lys Lys Val Asn Leu Asn Asp Lys Glu Ala Ile Thr 
        195                 200                 205             


Asn Ala Ile Leu Asn Asp Ser Phe Ser His Leu Leu Pro Lys Glu Asn 
    210                 215                 220                 


Thr Ile Ser Lys Tyr Tyr Ser Ala Val Pro Thr Glu Asp Ile Asp Thr 
225                 230                 235                 240 


Glu Asn Gly Val Thr Ile Ser Glu Ser Gly Ile Ile Phe Leu Leu Gly 
                245                 250                 255     


Leu Phe Leu Thr Lys Lys Gln Ser Glu Asp Leu Arg Ser Arg Val Lys 
            260                 265                 270         


Gly Phe Lys Ala Lys Leu Ile Val Asn Pro Glu Asn Pro Ile Asn Lys 
        275                 280                 285             


Lys Asn Asn Ser Leu Lys Tyr Met Ala Thr His Trp Val Phe Gly Tyr 
    290                 295                 300                 


Leu Gly Phe Lys Gly Leu Lys Asn Arg Phe Thr Thr Thr Phe Thr Lys 
305                 310                 315                 320 


Asp Thr Leu Leu Ala Gln Ile Val Asp Glu Leu Ser Lys Val Pro Asp 
                325                 330                 335     


Glu Leu Tyr Gln Val Leu Pro Glu Glu Leu Lys Asn Glu Phe Leu Glu 
            340                 345                 350         


Asp Met Asn Glu Tyr Leu Lys Glu Glu Asn Ser Glu Ser Leu Asp Lys 
        355                 360                 365             


Ala Thr Val Ile His Pro Val Ile Arg Lys Arg Tyr Glu Asn Lys Phe 
    370                 375                 380                 


Ala Tyr Phe Ala Leu Arg Phe Leu Asp Glu Phe Val Asp Phe Pro Thr 
385                 390                 395                 400 


Leu Arg Phe Gln Leu His Leu Gly Asn Tyr Val His Asp Lys Arg Glu 
                405                 410                 415     


Lys Pro Ile Glu Gly Thr Lys Tyr Val Thr Glu Arg Ile Val Lys Glu 
            420                 425                 430         


Lys Ile Lys Ala Phe Ala Lys Leu Ser Glu Ala Ala Gln Leu Lys Gln 
        435                 440                 445             


Lys Tyr Phe Glu Glu Lys Glu Asn His Gln Ser Ile Gly Leu Gln Leu 
    450                 455                 460                 


Tyr Pro Asn Pro Ser Tyr Asn Phe Val Gly Asn Asn Ile Pro Ile His 
465                 470                 475                 480 


Leu Asn Leu Asn Glu His Phe Phe Pro Lys Glu Val Lys Ile Val Ala 
                485                 490                 495     


Gly Arg Leu Lys Lys Arg Asn Ser Ser Tyr Lys Ser Asp His Pro Glu 
            500                 505                 510         


Glu Tyr Lys Val Arg Thr Asp Asn Lys Ile Lys Pro Asp Ala Ile Leu 
        515                 520                 525             


Gln Asp Leu Gly Lys Pro Glu Lys Leu Ala Pro Val Ala Met Leu Ser 
    530                 535                 540                 


Leu Asn Glu Leu Pro Ala Leu Leu His Leu Val Leu Thr Lys Lys Thr 
545                 550                 555                 560 


Pro Glu Glu Ile Glu Ile Ile Ile Ala Gln Lys Ile Ala Glu Arg Tyr 
                565                 570                 575     


Asn Val Leu Thr Asn Tyr Lys Ala Gly Asp Asp Ile Ser Lys Gly Gln 
            580                 585                 590         


Ile Thr Lys Asn Leu Leu Lys Ala Lys Gln Lys Lys Glu Val Asn Leu 
        595                 600                 605             


Asp Lys Leu Gln Leu Ala Ile Glu Lys Glu Ile Ala Val Thr Asn Asp 
    610                 615                 620                 


Lys Leu Gln Thr Ile Ala Leu His Ile Lys Glu Arg Asn Asp Pro Lys 
625                 630                 635                 640 


Gln Lys Arg Lys Tyr Val Phe Thr Asn Lys Glu Ile Gly Leu Gln Val 
                645                 650                 655     


Thr Trp Leu Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Gly Ser Arg 
            660                 665                 670         


Gln Asn Trp Arg Gly Gln His His Ser Gln Leu Gln Lys Ser Leu Ala 
        675                 680                 685             


Phe Tyr Asp Ile Gln Pro Lys Glu Pro Leu Ser Leu Leu Glu Glu Val 
    690                 695                 700                 


Trp Asp Phe Lys Asn Glu Ala Tyr Leu Trp Asn Asn Gly Ile Arg Arg 
705                 710                 715                 720 


Ser Phe Asp Lys Arg Asp Phe Ile Ser Phe Tyr Thr Ser Tyr Leu Asn 
                725                 730                 735     


Asn Arg Lys Glu Thr Phe Gln Arg Phe Lys Asp Gln Leu Asn Gly Ile 
            740                 745                 750         


Arg Ser Asn Lys Lys Ile Leu Asp Lys Phe Ile Lys Gln Gln His Leu 
        755                 760                 765             


Trp Asn Leu Phe His Lys Arg Leu Tyr Val Ile Asp Thr Ile Glu Glu 
    770                 775                 780                 


Gln Val Glu Lys Leu Leu Val Lys Pro Met Gln Phe Pro Lys Gly Val 
785                 790                 795                 800 


Phe Asp His Lys Pro Thr Tyr Ile Lys Gly Lys Ser Ile Gln Glu Asn 
                805                 810                 815     


Pro Glu Cys Phe Ala Asp Trp Tyr Val Ala Trp Asn Gln His Thr Asp 
            820                 825                 830         


Tyr Gln Lys Phe Tyr Ser Trp Asp Arg Asp Tyr Lys Ser Ala Tyr Leu 
        835                 840                 845             


Ser Gly Glu Gln Glu Lys Thr Glu Lys Arg Phe Ile Arg Val Gln Gly 
    850                 855                 860                 


Ser Lys Ile Asn Lys Val Lys Gln Gln Asp Val Leu Leu Ala Lys Met 
865                 870                 875                 880 


Ala Ser Ile Ile Phe Asn Glu Leu Tyr Leu Pro Glu Asp Ala Glu His 
                885                 890                 895     


Leu Asp Leu Asn Leu Ser Asp Ile Tyr Lys Thr Gln Thr Glu Arg Lys 
            900                 905                 910         


Ala Glu Ile Glu Ala Ala Leu Ile Gln Ser His Lys Thr Thr Gly Asp 
        915                 920                 925             


Asn Ser Ala Asn Ile Ile Lys Ser Thr Ser Ala Trp Thr Leu Thr Val 
    930                 935                 940                 


Pro Tyr Cys Ser Lys Asn Ile Tyr Glu Pro Gln Val Lys Leu Lys Glu 
945                 950                 955                 960 


Leu Gly Lys Phe Lys Lys Phe Ile Ala Ser Gln Lys Val Gln Thr Leu 
                965                 970                 975     


Phe Glu Tyr Lys Pro Gln Lys Ile Trp Asn Lys Thr Glu Leu Glu Glu 
            980                 985                 990         


Val Leu Glu Leu Lys Ala Asn Ser  Tyr Glu Val Ile Arg  Arg Asp Tyr 
        995                 1000                 1005             


Leu Leu  Lys Ser Ile Gln Glu  Phe Glu Lys Tyr Met  Ile Lys Lys 
    1010                 1015                 1020             


Leu Pro  Thr Leu Ile Asp Thr  Asn Glu His Pro Asn  Phe Asn Lys 
    1025                 1030                 1035             


Tyr Leu  Thr Thr Phe Leu Lys  Ser Leu Glu Leu Val  Ser Glu Glu 
    1040                 1045                 1050             


Asp Ala  Lys Trp Leu Ile Ser  Lys Lys Asp Phe Asp  Thr Thr Pro 
    1055                 1060                 1065             


Ile Asp  Glu Leu Lys Lys Gln  Ser Lys Ile Met Glu  Lys Ala Phe 
    1070                 1075                 1080             


Leu Leu  Val Met Ile Arg Asn  Lys Phe Ser His Asn  Gln Leu Pro 
    1085                 1090                 1095             


Arg Lys  Ile Tyr Tyr Asp Glu  Ile Tyr Lys Asn Val  Pro Asn Ala 
    1100                 1105                 1110             


Val Ser  Ile Asn Phe Asn Glu  Leu Phe Leu Glu Tyr  Thr Asn Gln 
    1115                 1120                 1125             


Thr Ile  Leu Glu Phe Lys 
    1130                 


<210>  2012
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2012

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2013
<211>  1144
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2013

Met Asp Ile Ile Pro Lys Leu Thr Tyr Thr Ile Glu Ser Thr Pro Trp 
1               5                   10                  15      


Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg His Asn Val Tyr Leu Leu 
            20                  25                  30          


Ile Asn His Leu Thr Glu Lys Phe Ser His Leu Lys Tyr Glu Lys Leu 
        35                  40                  45              


Lys Asp Asp Lys Glu Ile Lys Gly Lys Asn Ile Leu Thr Glu Ile Phe 
    50                  55                  60                  


Asp Thr Thr Lys Ser Asp Leu Asp Glu Glu Arg Phe Arg Ile Tyr Lys 
65                  70                  75                  80  


Tyr Leu Val Arg Gly His Tyr Leu Pro Phe Ile Lys Val Tyr Ser Asp 
                85                  90                  95      


Ser Lys Gly Asn Ala Leu Glu Asn Asn Pro Leu Val Tyr Tyr Asp Arg 
            100                 105                 110         


Leu His Gln Phe Ile Asn Asn Ser Phe Ala Leu Leu Val Lys Phe Arg 
        115                 120                 125             


Asp Ala Phe Ser His Tyr Leu Ala Leu Asp Glu His Gly Asn Ser Ile 
    130                 135                 140                 


Asp Ser Arg Gln Leu Asn Ile Asp His Glu Ile Ala His Asp Leu Glu 
145                 150                 155                 160 


Thr Ile Phe Gln Asp Ser Leu Ser Leu Ser Ala Ser Arg Phe Tyr Leu 
                165                 170                 175     


Thr Gln Gln Glu Ser Asp Phe Glu His Leu Lys His Tyr Ala Leu Phe 
            180                 185                 190         


Lys Glu Thr Glu Thr Lys Leu Ser Glu Asn Gly Phe Tyr Phe Phe Ile 
        195                 200                 205             


Cys Leu Phe Leu Glu Lys Gln Tyr Ala Ile Lys Phe Leu Lys Lys Ile 
    210                 215                 220                 


Lys Gly Phe Lys Asn Glu Thr Ile Pro Ala Phe Arg Ala Thr Leu Leu 
225                 230                 235                 240 


Ala Phe Thr His Tyr Thr Ile Arg Ile Pro Asp Ile Arg Leu Asp Asn 
                245                 250                 255     


Asp Glu Pro Arg Met Gly Val Leu Met Glu Met Leu Asn Glu Leu Gln 
            260                 265                 270         


Lys Cys Pro Ile Glu Leu Tyr Lys Arg Leu Thr Asp Glu Asp Lys Lys 
        275                 280                 285             


Lys Phe Glu Pro Ala Leu Asp Glu Glu Ser Gln Leu Asn Leu Ile Leu 
    290                 295                 300                 


Asn Ser Thr Ala Asn Ser Glu Asn Leu Ser Asp Glu Gln Thr Asp Ser 
305                 310                 315                 320 


Leu Leu Ile Asp Leu Thr Thr Leu Lys Arg His Gln Asn Arg Phe Ser 
                325                 330                 335     


Tyr Phe Ala Leu Arg Cys Ile Asp Glu Leu Asn Leu Leu Pro Gly Ile 
            340                 345                 350         


His Phe Gln Ile Thr Val Gly Lys Ile Glu Leu Arg Ala Tyr Pro Lys 
        355                 360                 365             


Val Ile Gly Lys Val Ala Thr Asn Arg Arg Ile Leu Lys Glu Val Asn 
    370                 375                 380                 


Ala Phe Gly Lys Leu Ser Ala Tyr Glu Gly Lys Glu Asn Trp Phe Ser 
385                 390                 395                 400 


Gln Gln Leu Lys Met Ile Tyr Glu Asp Glu Asn Leu Val Phe Asp Gln 
                405                 410                 415     


Tyr Asn Pro His Tyr Asn Ile Gln Glu Asn Lys Ile Ala Phe Tyr Val 
            420                 425                 430         


Leu Asp Ser Gly Thr Ser Gly Thr Leu Leu Pro Leu Lys Lys Lys Asn 
        435                 440                 445             


Thr Leu Pro Thr Gly Phe Leu Ser Leu Asn Asp Leu Pro Lys Leu Ile 
    450                 455                 460                 


Val Arg Ala Leu Asn Ser Pro Gly Arg Thr Val Ser Leu Ile Lys Asp 
465                 470                 475                 480 


Phe Ile Ala Lys Asn Glu Asn Ile Ile Leu Asn Glu Asp Ala Leu Val 
                485                 490                 495     


Ala Trp Lys Glu Gln Leu His Leu Asp Pro Ala Val Phe Thr Arg Arg 
            500                 505                 510         


Ile Ile Lys Glu Asn Ala Leu Arg Gly Lys Glu Gly Ile Ala Tyr Leu 
        515                 520                 525             


Thr Gln Arg Lys Thr Asp Ala Leu Phe Lys Arg Tyr Lys Ala Leu Ser 
    530                 535                 540                 


Ile Lys Ile Asp Ser Leu Ala Gly Leu Lys Lys Leu Ile Asp Gln Leu 
545                 550                 555                 560 


His Ser Lys Lys Asp Lys Glu Tyr Ile Ser Gln Ile Val Tyr Thr His 
                565                 570                 575     


Phe Leu Asn Lys Arg Lys Asp Ala Leu Ala Gly Ile Leu Pro Lys Gly 
            580                 585                 590         


Leu Pro Val Asn Gln Leu Pro Leu Lys Val Ile Asn Tyr Leu Leu Ser 
        595                 600                 605             


Leu Glu Thr Val Gly His Lys Lys Lys Phe Leu His Tyr Ile Lys Glu 
    610                 615                 620                 


Glu Lys Arg Thr Cys Lys Thr Arg Leu Lys Ala Leu Asn Lys Gln Glu 
625                 630                 635                 640 


Asn Asn Ala Pro Lys Ile Gly Glu Ile Ala Thr Phe Leu Ala Arg Asp 
                645                 650                 655     


Ile Ile Asn Met Val Val Asn Glu Glu Thr Lys Gln Asn Ile Thr Ser 
            660                 665                 670         


Ala Tyr Tyr Asn Arg Leu Gln Asn Lys Ile Ala Tyr Phe Ser Ile Ser 
        675                 680                 685             


Lys Pro Glu Ile Ala Glu Met Leu Thr Glu Leu Asn Leu Phe Asp Lys 
    690                 695                 700                 


Lys Thr Gly His Pro Phe Leu Asp Lys Gly Ser Ile Met Ala Ser Ser 
705                 710                 715                 720 


Gly Ile Leu Ala Phe Tyr Glu Tyr Tyr Leu Val Glu Lys Ala Ala Trp 
                725                 730                 735     


Ile Asp Lys Gln Ile Leu His Lys Asn Gln Leu Lys Lys Asp Leu Glu 
            740                 745                 750         


Ser His Leu Asn Lys Leu Pro Phe Ala Tyr Ala Arg Arg Tyr Gln Lys 
        755                 760                 765             


Asn Asn Glu Val Asn Phe Thr Lys Trp Leu Ile Asn Lys Lys Val Met 
    770                 775                 780                 


Pro Val Asn Ile Pro Asn Asn Leu Phe Asp Ala Asp Val Asn Lys Ile 
785                 790                 795                 800 


Leu Lys Asp Ser Leu Arg Lys Met Gly Ile Ala Phe Lys Asp Thr Glu 
                805                 810                 815     


Lys Phe Ala Leu Leu Leu Ser Lys Ser Met Met Gly Asp Thr Gln Pro 
            820                 825                 830         


Phe Tyr Thr Tyr Lys Arg Glu Tyr Thr Val Asp Gly Glu Lys Ile Pro 
        835                 840                 845             


Phe Tyr Pro Ala Asn Gln Ser Gly Lys Asp Ile Lys Thr Asp Tyr Gly 
    850                 855                 860                 


Lys His Ala Asp Ala Ser Glu Lys Glu Ile Arg Phe Ile Gln Thr Gln 
865                 870                 875                 880 


Asp Arg Val Ile Lys Leu Leu Cys Arg Asn Ile Ile Gln Ser Ile Val 
                885                 890                 895     


Lys Phe Lys Glu Ser Asn Leu Asp Ile Ile Leu Asn Asn Ile Tyr Pro 
            900                 905                 910         


Phe Ser Glu Thr Ser Val Leu Asn Ala Pro Gln Lys Phe Glu Phe Thr 
        915                 920                 925             


Leu Pro Lys Asn Gly Lys Lys Lys Ile Ile Val Ala Glu Asp Thr Ser 
    930                 935                 940                 


Ala Gln Lys Glu Gln Val Leu Arg Tyr Lys Gly Leu Ser Asp Leu Glu 
945                 950                 955                 960 


Glu Arg Lys Gln Tyr Asn Gly Gln Lys Gly Tyr Gln Trp Thr Ile Lys 
                965                 970                 975     


Asp Phe Gly Arg Phe Lys Arg Phe Val His Asp Arg Arg Leu Ser Glu 
            980                 985                 990         


Val Leu Asp Tyr Ile Asp Ala Pro  Asn Ala Thr Phe Asp  Leu Leu Ala 
        995                 1000                 1005             


Tyr Gln  Leu Asp Glu Tyr Asp  Arg Tyr Arg Val Glu  Ile Phe Gln 
    1010                 1015                 1020             


Gln Thr  Phe Asp Phe Glu Lys  Ala Ile Ala Ile Lys  His Leu Asp 
    1025                 1030                 1035             


Arg Val  Lys His Phe Asp Ser  Ile Asp Lys Ala Gly  Lys Lys Gly 
    1040                 1045                 1050             


Lys Ile  Ala Glu Val Ser Phe  Arg Val Tyr Leu Asp  Val Leu Lys 
    1055                 1060                 1065             


Glu Leu  Lys Ile Leu Ala Thr  Asp Glu Ala Asp Leu  Leu Lys Asn 
    1070                 1075                 1080             


Val Arg  Asn Lys Phe Ser His  Ser Glu Phe Pro Pro  Phe Ile Lys 
    1085                 1090                 1095             


Ser Leu  Thr Lys Ile Thr Ser  Glu Asn Ile Ala Ser  Phe Glu Ala 
    1100                 1105                 1110             


Asn Lys  Phe Thr Lys Asp Ala  Ile Ser Ala Leu Asp  Ile Ser Val 
    1115                 1120                 1125             


Pro Ser  Lys Ile Leu Asn Glu  Tyr Lys Ala Val Leu  Ser Lys Phe 
    1130                 1135                 1140             


Ser 
    


<210>  2014
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2014

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2015
<211>  1134
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2015

Met Asn Glu Thr Asp Tyr Leu Ala Lys Arg Leu Glu Tyr Asn Tyr Ala 
1               5                   10                  15      


Ser Ile Glu Asp Lys His Tyr Phe Gly Gly Tyr Phe Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asn Asp Leu Ser Lys Ala Phe Lys Glu Lys Phe Gly Met 
        35                  40                  45              


Lys Pro Lys Ser Cys Ile Leu Asp Phe Phe Thr Gln Asp Lys Ala Ile 
    50                  55                  60                  


Ala Glu Tyr Gln Leu Gly Val Glu Phe Leu Gln Lys Asn Leu Pro Val 
65                  70                  75                  80  


Ile Arg Tyr Leu Tyr Leu Pro Thr Ser His Lys Arg Phe Glu Asn Val 
                85                  90                  95      


Pro Lys Asn Gln Leu Ile Ser Glu Gln Arg Asn Tyr Phe Lys Asn Ser 
            100                 105                 110         


Leu Lys Val Leu Lys Asn Leu Ile Arg Asp Tyr Arg Asn Phe Tyr Thr 
        115                 120                 125             


His His Phe His Lys Pro Ile Pro Val Phe Pro Glu Thr Tyr Lys Leu 
    130                 135                 140                 


Leu Asp Asp Leu Phe Leu Ala Val Ala Asn Asp Val Lys Lys His Arg 
145                 150                 155                 160 


Met Lys Thr Asp Ala Ser Lys Gln Leu Leu Lys Lys Gly Leu Ile Glu 
                165                 170                 175     


Glu Leu Ala Gln Leu Glu Lys Leu Lys Leu Glu Asp Leu Lys Lys Leu 
            180                 185                 190         


Lys Arg Glu Gly Lys Lys Val Asn Leu Asn Asp Lys Glu Ala Ile Thr 
        195                 200                 205             


Asn Ala Ile Leu Asn Asp Ser Phe Ser His Leu Leu Pro Lys Glu Asn 
    210                 215                 220                 


Thr Ile Ser Lys Tyr Tyr Ser Ala Val Pro Thr Glu Asp Ile Asp Thr 
225                 230                 235                 240 


Glu Asn Gly Val Thr Ile Ser Glu Ser Gly Ile Ile Phe Leu Leu Gly 
                245                 250                 255     


Leu Phe Leu Thr Lys Lys Gln Ser Glu Asp Leu Arg Ser Arg Val Lys 
            260                 265                 270         


Gly Phe Lys Ala Lys Leu Ile Val Asn Pro Glu Asn Pro Ile Asn Lys 
        275                 280                 285             


Lys Asn Asn Ser Leu Lys Tyr Met Ala Thr His Trp Val Phe Gly Tyr 
    290                 295                 300                 


Leu Gly Phe Lys Gly Leu Lys Asn Arg Phe Thr Thr Thr Phe Thr Lys 
305                 310                 315                 320 


Asp Thr Leu Leu Ala Gln Ile Val Asp Glu Leu Ser Lys Val Pro Asp 
                325                 330                 335     


Glu Leu Tyr Gln Val Leu Pro Glu Glu Leu Lys Asn Glu Phe Leu Glu 
            340                 345                 350         


Asp Met Asn Glu Tyr Leu Lys Glu Glu Asn Ser Glu Ser Leu Asp Lys 
        355                 360                 365             


Ala Thr Val Ile His Pro Val Ile Arg Lys Arg Tyr Glu Asn Lys Phe 
    370                 375                 380                 


Ala Tyr Phe Ala Leu Arg Phe Leu Asp Glu Phe Val Asp Phe Pro Thr 
385                 390                 395                 400 


Leu Arg Phe Gln Leu His Leu Gly Asn Tyr Val His Asp Lys Arg Glu 
                405                 410                 415     


Lys Pro Ile Glu Gly Thr Lys Tyr Val Thr Glu Arg Ile Val Lys Glu 
            420                 425                 430         


Lys Ile Lys Ala Phe Ala Lys Leu Ser Glu Ala Ala Gln Leu Lys Gln 
        435                 440                 445             


Lys Tyr Phe Glu Glu Lys Glu Asn His Gln Ser Ile Gly Leu Gln Leu 
    450                 455                 460                 


Tyr Pro Asn Pro Ser Tyr Asn Phe Val Gly Asn Asn Ile Pro Ile His 
465                 470                 475                 480 


Leu Asn Leu Asn Glu His Phe Phe Pro Lys Glu Val Lys Ile Val Ala 
                485                 490                 495     


Gly Arg Leu Lys Lys Arg Asn Ser Ser Tyr Lys Ser Asp His Pro Glu 
            500                 505                 510         


Glu Tyr Lys Val Arg Thr Asp Asn Lys Ile Lys Pro Asp Ala Ile Leu 
        515                 520                 525             


Gln Asp Leu Gly Lys Pro Glu Lys Leu Ala Pro Val Ala Met Leu Ser 
    530                 535                 540                 


Leu Asn Glu Leu Pro Ala Leu Leu His Leu Val Leu Thr Lys Lys Thr 
545                 550                 555                 560 


Pro Glu Glu Ile Glu Ile Ile Ile Ala Gln Lys Ile Ala Glu Arg Tyr 
                565                 570                 575     


Asn Val Leu Thr Asn Tyr Lys Ala Gly Asp Asp Ile Ser Lys Gly Gln 
            580                 585                 590         


Ile Thr Lys Asn Leu Leu Lys Ala Lys Gln Lys Lys Glu Val Asn Leu 
        595                 600                 605             


Asp Lys Leu Gln Leu Ala Ile Glu Lys Glu Ile Ala Val Thr Asn Asp 
    610                 615                 620                 


Lys Leu Gln Thr Ile Ala Leu His Ile Lys Glu Arg Asn Asp Pro Lys 
625                 630                 635                 640 


Gln Lys Arg Lys Tyr Val Phe Thr Asn Lys Glu Ile Gly Leu Gln Val 
                645                 650                 655     


Thr Trp Leu Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Gly Ser Arg 
            660                 665                 670         


Gln Asn Trp Arg Gly Gln His His Ser Gln Leu Gln Lys Ser Leu Ala 
        675                 680                 685             


Phe Tyr Asp Ile Gln Pro Lys Glu Pro Leu Ser Leu Leu Glu Glu Val 
    690                 695                 700                 


Trp Asp Phe Lys Asn Glu Ala Tyr Leu Trp Asn Asn Gly Ile Arg Arg 
705                 710                 715                 720 


Ser Phe Asp Lys Arg Asp Phe Ile Ser Phe Tyr Thr Ser Tyr Leu Asn 
                725                 730                 735     


Asn Arg Lys Glu Thr Phe Gln Arg Phe Lys Asp Gln Leu Asn Gly Ile 
            740                 745                 750         


Arg Ser Asn Lys Lys Ile Leu Asp Lys Phe Ile Lys Gln Gln His Leu 
        755                 760                 765             


Trp Asn Leu Phe His Lys Arg Leu Tyr Val Ile Asp Thr Ile Glu Glu 
    770                 775                 780                 


Gln Val Glu Lys Leu Leu Val Lys Pro Met Gln Phe Pro Lys Gly Val 
785                 790                 795                 800 


Phe Asp His Lys Pro Thr Tyr Ile Lys Gly Lys Ser Ile Gln Glu Asn 
                805                 810                 815     


Pro Glu Cys Phe Ala Asp Trp Tyr Val Ala Trp Asn Gln His Thr Asp 
            820                 825                 830         


Tyr Gln Lys Phe Tyr Ser Trp Asp Arg Asp Tyr Lys Ser Ala Tyr Leu 
        835                 840                 845             


Ser Gly Glu Gln Glu Lys Thr Glu Lys Arg Phe Ile Arg Val Gln Gly 
    850                 855                 860                 


Ser Lys Ile Asn Lys Val Lys Gln Gln Asp Val Leu Leu Ala Lys Met 
865                 870                 875                 880 


Ala Ser Ile Ile Phe Asn Glu Leu Tyr Leu Pro Glu Asp Ala Glu His 
                885                 890                 895     


Leu Asp Leu Asn Leu Ser Asp Ile Tyr Lys Thr Gln Thr Glu Arg Lys 
            900                 905                 910         


Ala Glu Ile Glu Ala Ala Leu Ile Gln Ser His Lys Thr Thr Gly Asp 
        915                 920                 925             


Asn Ser Ala Asn Ile Ile Lys Ser Thr Ser Ala Trp Thr Leu Thr Val 
    930                 935                 940                 


Pro Tyr Cys Ser Lys Asn Ile Tyr Glu Pro Gln Val Lys Leu Lys Glu 
945                 950                 955                 960 


Leu Gly Lys Phe Lys Lys Phe Ile Ala Ser Gln Lys Val Gln Thr Leu 
                965                 970                 975     


Phe Glu Tyr Lys Pro Gln Lys Ile Trp Asn Lys Thr Glu Leu Glu Glu 
            980                 985                 990         


Val Leu Glu Leu Lys Ala Asn Ser  Tyr Glu Val Ile Arg  Arg Asp Tyr 
        995                 1000                 1005             


Leu Leu  Lys Ser Ile Gln Glu  Phe Glu Lys Tyr Met  Ile Lys Lys 
    1010                 1015                 1020             


Leu Pro  Thr Leu Ile Asp Thr  Asn Glu His Pro Asn  Phe Asn Lys 
    1025                 1030                 1035             


Tyr Leu  Thr Thr Phe Leu Lys  Ser Leu Glu Leu Val  Ser Glu Glu 
    1040                 1045                 1050             


Asp Ala  Lys Trp Leu Ile Ser  Lys Lys Asp Phe Asp  Thr Thr Pro 
    1055                 1060                 1065             


Ile Asp  Glu Leu Lys Lys Gln  Ser Lys Ile Met Glu  Lys Ala Phe 
    1070                 1075                 1080             


Leu Leu  Val Met Ile Arg Asn  Lys Phe Ser His Asn  Gln Leu Pro 
    1085                 1090                 1095             


Arg Lys  Ile Tyr Tyr Asp Glu  Ile Tyr Lys Asn Val  Pro Asn Ala 
    1100                 1105                 1110             


Val Ser  Ile Asn Phe Asn Glu  Leu Phe Leu Glu Tyr  Thr Asn Gln 
    1115                 1120                 1125             


Thr Ile  Leu Glu Phe Lys 
    1130                 


<210>  2016
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2016

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2017
<211>  1130
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2017

Met Glu Thr Thr Ala Thr Phe Arg Asn Tyr Asn Cys Arg Asn Ser Phe 
1               5                   10                  15      


Lys Gln Ile Phe Asn Phe Lys Gly Ala Ile Ala Pro Ile Ala Glu Lys 
            20                  25                  30          


Ala Ser Arg Asn Phe Thr Leu Lys Thr Lys Asn Pro Val Asn Arg Glu 
        35                  40                  45              


Gln Arg Leu His Tyr Phe Ala Leu Ala Tyr Ser Phe Lys Gln Leu Asp 
    50                  55                  60                  


Thr Glu Asn Leu Phe Glu Lys Val Leu Asp Glu Thr Leu Arg Glu Lys 
65                  70                  75                  80  


Arg Pro Thr Lys Phe Leu Ala Leu Gln Lys Phe Asp Ser Ala Phe Cys 
                85                  90                  95      


Ile Glu Leu Asn Lys Val Val Gly Ile Ile Arg Asn Ile Asn Ser His 
            100                 105                 110         


Tyr Ile His Asp Phe Glu Lys Leu Lys Thr Asp Glu Ile His Pro Ser 
        115                 120                 125             


Val Leu Ala Phe Leu Lys Glu Ser Phe Asp Val Ala Leu Ile Gln Ile 
    130                 135                 140                 


Tyr Leu Lys Glu Lys Glu Ile Thr Tyr Glu Gln Phe Val Gly Ser Gly 
145                 150                 155                 160 


Asp Ile Asp Lys Arg Leu Val Gly Phe Met His Asp Lys Phe Tyr Pro 
                165                 170                 175     


Leu Asp Asp Lys Lys Thr Tyr Pro Glu Glu Tyr Leu Glu Ile Arg Lys 
            180                 185                 190         


Glu Phe Lys Ser Leu Ser Lys Lys Glu Ala Ile Asp Thr Ile Leu Phe 
        195                 200                 205             


Val Glu Val Asp Ser Ser Phe Asp Trp Met Val Phe Asp Thr His Lys 
    210                 215                 220                 


Ala Phe Thr Val Ser Ser Gly Lys Tyr Leu Ser Phe Tyr Ala Cys Leu 
225                 230                 235                 240 


Phe Leu Leu Ser Met Phe Leu Tyr Lys Ser Glu Ala Asn Gln Leu Ile 
                245                 250                 255     


Ser Lys Ile Lys Gly Phe Lys Lys Asn Thr Thr Asp Glu Glu Lys Ser 
            260                 265                 270         


Lys Arg Glu Ile Phe Ser Phe Phe Ser Lys Lys Phe Ser Ser Gln Asp 
        275                 280                 285             


Ile Asp Ser Glu Glu Asn His Leu Val Lys Phe Arg Asp Leu Ile Gln 
    290                 295                 300                 


Tyr Leu Asn Arg Tyr Ser Leu Ala Trp Asn Lys Asp Leu Glu Leu Ala 
305                 310                 315                 320 


Ser Gly His Pro Leu Met Thr Asp Arg Leu Lys Ala Thr Ile Ile Asp 
                325                 330                 335     


Met Glu Ile Asp Arg Ser Phe Pro Leu Phe Thr Gly Asn Lys Arg Phe 
            340                 345                 350         


Lys Glu Tyr Ala Arg Leu Lys Leu Trp Asn Asp Lys Ser Ile Asn Asn 
        355                 360                 365             


Ala Phe Thr Asp Glu Glu Lys Thr Ser Phe Asp Tyr Glu Ile Asn Thr 
    370                 375                 380                 


Cys Pro Glu Leu Lys Asp Ala His Thr Lys Leu Glu Glu Leu Lys Gln 
385                 390                 395                 400 


Met Lys Gly Leu Tyr Gly His Lys Lys Glu Arg Asn Glu Lys Glu Ile 
                405                 410                 415     


Tyr Arg Thr Lys Lys Thr Ile Leu Thr Lys Ala Asn Glu Pro Asn Pro 
            420                 425                 430         


Ile Lys Glu Lys Leu Glu Asn Arg Ile Lys Asn Asn Leu Leu Phe Val 
        435                 440                 445             


Ser Tyr Gly Arg Asn Gln Asp Arg Phe Met Asp Phe Ala Thr Arg Tyr 
    450                 455                 460                 


Leu Ala Glu Thr Lys Tyr Phe Gly Val Asp Ala Gln Phe Lys Leu Tyr 
465                 470                 475                 480 


Gln Phe Phe Thr Ser Glu Glu Gln Asn Val Glu Met Asp Arg Leu Lys 
                485                 490                 495     


Lys Thr Leu Pro Lys Lys Glu Tyr Asp Asn Leu Lys Phe His Gln Gly 
            500                 505                 510         


Lys Leu Val His Tyr Ser Thr Phe Glu Glu Gln Leu Ala Arg Tyr Glu 
        515                 520                 525             


Ser Trp Asp Thr Pro Phe Val Ile Glu Asn Asn Ala Ile Gln Ile Lys 
    530                 535                 540                 


Met Asn Leu Gly Asn Gly Ile Asp Lys Ile Val Ser Ile Gln Arg Gly 
545                 550                 555                 560 


Leu Met Val Tyr Leu Leu Glu Asp Ala Leu Tyr Asn Val Lys Pro Glu 
                565                 570                 575     


Ala Ile Glu Asn Ala Gly Lys Lys Leu Leu Thr Ala Tyr Tyr Ala Gln 
            580                 585                 590         


His Gln Ala Glu Phe Thr Thr Ser Lys Leu Ile Leu Gln Glu Gln Asp 
        595                 600                 605             


Ser Ile Ser Pro Glu Gln Lys Asn Lys Phe Lys Lys Ile Leu Pro Lys 
    610                 615                 620                 


Arg Leu Leu His Arg Tyr Ser Pro Ala Ile Gln Asn Tyr Leu Pro Glu 
625                 630                 635                 640 


His Asn Thr Leu Gln Leu Ile Leu Glu Lys Ala Lys Asp Ser Glu Ala 
                645                 650                 655     


Arg Tyr Glu Lys Leu Val Glu Lys Ala Lys Ala Glu Gly Lys Tyr Glu 
            660                 665                 670         


Asp Phe Val Lys Arg Asn Lys Gly Lys Gln Phe Lys Leu Gln Phe Val 
        675                 680                 685             


Arg Lys Ala Trp His Leu Met Tyr Phe Lys Asp Ser Tyr Met Gln Gln 
    690                 695                 700                 


Val Ala Val Ser Gly His His Lys Arg Phe His Ile Glu Arg Asp Glu 
705                 710                 715                 720 


Phe Asn Asp Phe Ser Arg Tyr Leu Phe Ala Phe Asp Glu Val Ala Leu 
                725                 730                 735     


Tyr Lys Asp Tyr Leu His Glu Met Leu Glu Lys Lys Gly Phe Leu Glu 
            740                 745                 750         


Asn Val Ala Phe Lys Thr Leu Phe Glu Ser Gly Ser Ser Leu Asp Asn 
        755                 760                 765             


Leu Tyr Val Lys Thr Lys Gln Ala Tyr Gln Ala Trp Ile His Thr Gln 
    770                 775                 780                 


Ala Glu Arg Glu Gln Val Ser Asp Lys Tyr Ser Ile Ala Asn Tyr Asn 
785                 790                 795                 800 


Lys Leu Phe Glu Asp Asp Leu Phe Tyr Ile Asn Arg Ser His Phe Ile 
                805                 810                 815     


Asp Tyr Leu Lys Ser Ser Ser Lys Leu Gln Val Asp Ala Gln Gly Trp 
            820                 825                 830         


Met Arg Phe Arg Ala Leu Glu Asn Ala Pro Tyr Leu Ile Pro Ala Tyr 
        835                 840                 845             


Tyr Tyr Ala Asp Lys Leu Ile Lys Glu Glu Thr Lys Ser Cys Gly Lys 
    850                 855                 860                 


Leu Tyr Asn Lys Leu Asn Ala Thr Arg Leu Glu Asp Val Met Leu Tyr 
865                 870                 875                 880 


Glu Ile Gly Met Arg Tyr Leu Gln Leu Asp Lys Gln Ile Val Gln Lys 
                885                 890                 895     


Ala Lys Lys Pro Val Ile Glu Ile Leu Asn Gln Asp Val Ala Leu Asp 
            900                 905                 910         


Ile Lys Asp Val Gln Asn Lys His Leu Tyr Gln Leu Gln Ile Pro Phe 
        915                 920                 925             


Asn Lys Ile Asp Glu Phe Val Gly Leu Ile Ala His Lys Gly Glu Gln 
    930                 935                 940                 


Asp Val Gln Phe Lys Ser Ser Tyr Leu Ala Asn Ile Val Ala Tyr Leu 
945                 950                 955                 960 


Glu Lys Val Gln Arg His Lys Asp Ile Lys Ser Val Tyr Ala Ser Phe 
                965                 970                 975     


Thr Ala Asn Pro Leu Lys Lys Val Leu Thr Tyr Asp Asp Leu His Lys 
            980                 985                 990         


Ile Asp Gly His Leu Val Ser Asn  Ser Ile Lys Phe Thr  Asn Leu Ala 
        995                 1000                 1005             


Leu Ala  Lys Glu Leu Tyr Phe  Val His Lys His Ser  Ile Ser Ile 
    1010                 1015                 1020             


Gln Lys  Asp Asn Arg Ile Thr  Tyr Asp Glu Ile Ile  Ala Leu Lys 
    1025                 1030                 1035             


Pro Tyr  Phe Asn Ile Thr Thr  Arg Asn Lys Ala Phe  His Phe Gly 
    1040                 1045                 1050             


Val Pro  Asn Ile Ser Tyr Pro  Gln Met Val Ser Glu  Ile Glu Lys 
    1055                 1060                 1065             


Lys Phe  Ile Ala Asp Glu Val  Arg Pro Thr Ala Pro  Ser Asn Phe 
    1070                 1075                 1080             


Glu Asp  Leu Ser Lys Pro Leu  Lys Ser Ile Cys Asn  Ile Leu Leu 
    1085                 1090                 1095             


Glu Thr  Leu His Asn Asp Tyr  Phe Gly Gln Glu Arg  Asp Gly Lys 
    1100                 1105                 1110             


Lys Lys  Arg Lys Asp Ala Glu  Gln Arg Tyr Phe Asn  Glu Val Ile 
    1115                 1120                 1125             


Ala Lys  
    1130 


<210>  2018
<211>  1144
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2018

Met Asp Ile Ile Pro Lys Leu Thr Tyr Thr Ile Glu Ser Thr Pro Trp 
1               5                   10                  15      


Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg His Asn Val Tyr Leu Leu 
            20                  25                  30          


Ile Asn His Leu Thr Glu Lys Phe Ser His Leu Lys Tyr Glu Lys Leu 
        35                  40                  45              


Lys Asp Asp Lys Glu Ile Lys Gly Lys Asn Ile Leu Thr Glu Ile Phe 
    50                  55                  60                  


Asp Thr Thr Lys Ser Asp Leu Asp Glu Glu Arg Phe Arg Ile Tyr Lys 
65                  70                  75                  80  


Tyr Leu Val Arg Gly His Tyr Leu Pro Phe Ile Lys Val Tyr Ser Asp 
                85                  90                  95      


Ser Lys Gly Asn Ala Leu Glu Asn Asn Pro Leu Val Tyr Tyr Asp Arg 
            100                 105                 110         


Leu His Gln Phe Ile Asn Asn Ser Phe Ala Leu Leu Val Lys Phe Arg 
        115                 120                 125             


Asp Ala Phe Ser His Tyr Leu Ala Leu Asp Glu His Gly Asn Ser Ile 
    130                 135                 140                 


Asp Ser Arg Gln Leu Asn Ile Asp His Glu Ile Ala His Asp Leu Glu 
145                 150                 155                 160 


Thr Ile Phe Gln Asp Ser Leu Ser Leu Ser Ala Ser Arg Phe Tyr Leu 
                165                 170                 175     


Thr Gln Gln Glu Ser Asp Phe Glu His Leu Lys His Tyr Ala Leu Phe 
            180                 185                 190         


Lys Glu Thr Glu Thr Lys Leu Ser Glu Asn Gly Phe Tyr Phe Phe Ile 
        195                 200                 205             


Cys Leu Phe Leu Glu Lys Gln Tyr Ala Ile Lys Phe Leu Lys Lys Ile 
    210                 215                 220                 


Lys Gly Phe Lys Asn Glu Thr Ile Pro Ala Phe Arg Ala Thr Leu Leu 
225                 230                 235                 240 


Ala Phe Thr His Tyr Thr Ile Arg Ile Pro Asp Ile Arg Leu Asp Asn 
                245                 250                 255     


Asp Glu Pro Arg Met Gly Val Leu Met Glu Met Leu Asn Glu Leu Gln 
            260                 265                 270         


Lys Cys Pro Ile Glu Leu Tyr Lys Arg Leu Thr Asp Glu Asp Lys Lys 
        275                 280                 285             


Lys Phe Glu Pro Ala Leu Asp Glu Glu Ser Gln Leu Asn Leu Ile Leu 
    290                 295                 300                 


Asn Ser Thr Ala Asn Ser Glu Asn Leu Ser Asp Glu Gln Thr Asp Ser 
305                 310                 315                 320 


Leu Leu Ile Asp Leu Thr Thr Leu Lys Arg His Gln Asn Arg Phe Ser 
                325                 330                 335     


Tyr Phe Ala Leu Arg Cys Ile Asp Glu Leu Asn Leu Leu Pro Gly Ile 
            340                 345                 350         


His Phe Gln Ile Thr Val Gly Lys Ile Glu Leu Arg Ala Tyr Pro Lys 
        355                 360                 365             


Val Ile Gly Lys Val Ala Thr Asn Arg Arg Ile Leu Lys Glu Val Asn 
    370                 375                 380                 


Ala Phe Gly Lys Leu Ser Ala Tyr Glu Gly Lys Glu Asn Trp Phe Ser 
385                 390                 395                 400 


Gln Gln Leu Lys Met Ile Tyr Glu Asp Glu Asn Leu Val Phe Asp Gln 
                405                 410                 415     


Tyr Asn Pro His Tyr Asn Ile Gln Glu Asn Lys Ile Ala Phe Tyr Val 
            420                 425                 430         


Leu Asp Ser Gly Thr Ser Gly Thr Leu Leu Pro Leu Lys Lys Lys Asn 
        435                 440                 445             


Thr Leu Pro Thr Gly Phe Leu Ser Leu Asn Asp Leu Pro Lys Leu Ile 
    450                 455                 460                 


Val Arg Ala Leu Asn Ser Pro Gly Arg Thr Val Ser Leu Ile Lys Asp 
465                 470                 475                 480 


Phe Ile Ala Lys Asn Glu Asn Ile Ile Leu Asn Glu Asp Ala Leu Val 
                485                 490                 495     


Ala Trp Lys Glu Gln Leu His Leu Asp Pro Ala Val Phe Thr Arg Arg 
            500                 505                 510         


Ile Ile Lys Glu Asn Ala Leu Arg Gly Lys Glu Gly Ile Ala Tyr Leu 
        515                 520                 525             


Thr Gln Arg Lys Thr Asp Ala Leu Phe Lys Arg Tyr Lys Ala Leu Ser 
    530                 535                 540                 


Ile Lys Ile Asp Ser Leu Ala Gly Leu Lys Lys Leu Ile Asp Gln Leu 
545                 550                 555                 560 


His Ser Lys Lys Asp Lys Glu Tyr Ile Ser Gln Ile Val Tyr Thr His 
                565                 570                 575     


Phe Leu Asn Lys Arg Lys Asp Ala Leu Ala Gly Ile Leu Pro Lys Gly 
            580                 585                 590         


Leu Pro Val Asn Gln Leu Pro Leu Lys Val Ile Asn Tyr Leu Leu Ser 
        595                 600                 605             


Leu Glu Thr Val Gly His Lys Lys Lys Phe Leu His Tyr Ile Lys Glu 
    610                 615                 620                 


Glu Lys Arg Thr Cys Lys Thr Arg Leu Lys Ala Leu Asn Lys Gln Glu 
625                 630                 635                 640 


Asn Asn Ala Pro Lys Ile Gly Glu Ile Ala Thr Phe Leu Ala Arg Asp 
                645                 650                 655     


Ile Ile Asn Met Val Val Asn Glu Glu Thr Lys Gln Asn Ile Thr Ser 
            660                 665                 670         


Ala Tyr Tyr Asn Arg Leu Gln Asn Lys Ile Ala Tyr Phe Ser Ile Ser 
        675                 680                 685             


Lys Pro Glu Ile Ala Glu Met Leu Thr Glu Leu Asn Leu Phe Asp Lys 
    690                 695                 700                 


Lys Thr Gly His Pro Phe Leu Asp Lys Gly Ser Ile Met Ala Ser Ser 
705                 710                 715                 720 


Gly Ile Leu Ala Phe Tyr Glu Tyr Tyr Leu Val Glu Lys Ala Ala Trp 
                725                 730                 735     


Ile Asp Lys Gln Ile Leu His Lys Asn Gln Leu Lys Lys Asp Leu Glu 
            740                 745                 750         


Ser His Leu Asn Lys Leu Pro Phe Ala Tyr Ala Arg Arg Tyr Gln Lys 
        755                 760                 765             


Asn Asn Glu Val Asn Phe Thr Lys Trp Leu Ile Asn Lys Lys Val Met 
    770                 775                 780                 


Pro Val Asn Ile Pro Asn Asn Leu Phe Asp Ala Asp Val Asn Lys Ile 
785                 790                 795                 800 


Leu Lys Asp Ser Leu Arg Lys Met Gly Ile Ala Phe Lys Asp Thr Glu 
                805                 810                 815     


Lys Phe Ala Leu Leu Leu Ser Lys Ser Met Met Gly Asp Thr Gln Pro 
            820                 825                 830         


Phe Tyr Thr Tyr Lys Arg Glu Tyr Thr Val Asp Gly Glu Lys Ile Pro 
        835                 840                 845             


Phe Tyr Pro Ala Asn Gln Ser Gly Lys Asp Ile Lys Thr Asp Tyr Gly 
    850                 855                 860                 


Lys His Ala Asp Ala Ser Glu Lys Glu Ile Arg Phe Ile Gln Thr Gln 
865                 870                 875                 880 


Asp Arg Val Ile Lys Leu Leu Cys Arg Asn Ile Ile Gln Ser Ile Val 
                885                 890                 895     


Lys Phe Lys Glu Ser Asn Leu Asp Ile Ile Leu Asn Asn Ile Tyr Pro 
            900                 905                 910         


Phe Ser Glu Thr Ser Val Leu Asn Ala Pro Gln Lys Phe Glu Phe Thr 
        915                 920                 925             


Leu Pro Lys Asn Gly Lys Lys Lys Ile Ile Val Ala Glu Asp Thr Ser 
    930                 935                 940                 


Ala Gln Lys Glu Gln Val Leu Arg Tyr Lys Gly Leu Ser Asp Leu Glu 
945                 950                 955                 960 


Glu Arg Lys Gln Tyr Asn Gly Gln Lys Gly Tyr Gln Trp Thr Ile Lys 
                965                 970                 975     


Asp Phe Gly Arg Phe Lys Arg Phe Val His Asp Arg Arg Leu Ser Glu 
            980                 985                 990         


Val Leu Asp Tyr Ile Asp Ala Pro  Asn Ala Thr Phe Asp  Leu Leu Ala 
        995                 1000                 1005             


Tyr Gln  Leu Asp Glu Tyr Asp  Arg Tyr Arg Val Glu  Ile Phe Gln 
    1010                 1015                 1020             


Gln Thr  Phe Asp Phe Glu Lys  Ala Ile Ala Ile Lys  His Leu Asp 
    1025                 1030                 1035             


Arg Val  Lys His Phe Asp Ser  Ile Asp Lys Ala Gly  Lys Lys Gly 
    1040                 1045                 1050             


Lys Ile  Ala Glu Val Ser Phe  Arg Val Tyr Leu Asp  Val Leu Lys 
    1055                 1060                 1065             


Glu Leu  Lys Ile Leu Ala Thr  Asp Glu Ala Asp Leu  Leu Lys Asn 
    1070                 1075                 1080             


Val Arg  Asn Lys Phe Ser His  Ser Glu Phe Pro Pro  Phe Ile Lys 
    1085                 1090                 1095             


Ser Leu  Thr Lys Ile Thr Ser  Glu Asn Ile Ala Ser  Phe Glu Ala 
    1100                 1105                 1110             


Asn Lys  Phe Thr Lys Asp Ala  Ile Ser Ala Leu Asp  Ile Ser Val 
    1115                 1120                 1125             


Pro Ser  Lys Ile Leu Asn Glu  Tyr Lys Ala Val Leu  Ser Lys Phe 
    1130                 1135                 1140             


Ser 
    


<210>  2019
<211>  1152
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2019

Met Lys Asp Ile Leu Thr Thr Glu Lys Gln Asn Arg Phe Tyr Ser His 
1               5                   10                  15      


Lys Ile Ala Asp Lys Tyr Phe Phe Gly Gly Tyr Phe Asn Leu Ala Ser 
            20                  25                  30          


Asn Asn Ile Tyr Glu Val Phe Glu Glu Val Asn Lys Arg Asn Thr Phe 
        35                  40                  45              


Gly Lys Leu Ala Lys Arg Asp Asn Gly Asn Leu Lys Asn Tyr Ile Ile 
    50                  55                  60                  


His Val Phe Lys Asp Glu Leu Ser Ile Ser Asp Phe Glu Lys Arg Val 
65                  70                  75                  80  


Ala Ile Phe Ala Ser Tyr Phe Pro Ile Leu Glu Thr Val Asp Lys Lys 
                85                  90                  95      


Ser Ile Lys Glu Arg Asn Arg Thr Ile Asp Leu Thr Leu Ser Gln Arg 
            100                 105                 110         


Ile Arg Gln Phe Arg Glu Met Leu Ile Ser Leu Val Thr Ala Val Asp 
        115                 120                 125             


Gln Leu Arg Asn Phe Tyr Thr His Tyr His His Ser Glu Ile Val Ile 
    130                 135                 140                 


Glu Asn Lys Val Leu Asp Phe Leu Asn Ser Ser Phe Val Ser Thr Ala 
145                 150                 155                 160 


Leu His Val Lys Asp Lys Tyr Leu Lys Thr Asp Lys Thr Lys Glu Phe 
                165                 170                 175     


Leu Lys Glu Thr Ile Ala Ala Glu Leu Asp Ile Leu Ile Glu Ala Tyr 
            180                 185                 190         


Lys Lys Lys Gln Ile Glu Lys Lys Asn Thr Arg Phe Lys Ala Asn Lys 
        195                 200                 205             


Arg Glu Asp Ile Leu Asn Ala Ile Tyr Asn Glu Ala Phe Trp Ser Phe 
    210                 215                 220                 


Ile Asn Asp Lys Asp Lys Glu Thr Val Val Ala Lys Gly Ala Asp Ala 
225                 230                 235                 240 


Tyr Phe Glu Lys Asn His His Lys Ser Asn Asp Pro Asp Phe Ala Leu 
                245                 250                 255     


Asn Ile Ser Glu Lys Gly Ile Val Tyr Leu Leu Ser Phe Phe Leu Thr 
            260                 265                 270         


Asn Lys Glu Met Asp Ser Leu Lys Ala Asn Leu Thr Gly Phe Lys Gly 
        275                 280                 285             


Lys Val Asp Arg Glu Ser Gly Asn Ser Ile Lys Tyr Met Ala Thr Gln 
    290                 295                 300                 


Arg Ile Tyr Ser Phe His Thr Tyr Arg Gly Leu Lys Gln Lys Ile Arg 
305                 310                 315                 320 


Thr Ser Glu Glu Gly Val Lys Glu Thr Leu Leu Met Gln Met Ile Asp 
                325                 330                 335     


Glu Leu Ser Lys Val Pro Asn Val Val Tyr Gln His Leu Ser Thr Thr 
            340                 345                 350         


Gln Gln Asn Ser Phe Ile Glu Asp Trp Asn Glu Tyr Tyr Lys Asp Tyr 
        355                 360                 365             


Glu Asp Asp Val Glu Thr Asp Asp Leu Ser Arg Val Ile His Pro Val 
    370                 375                 380                 


Ile Arg Lys Arg Tyr Glu Asp Arg Phe Asn Tyr Phe Ala Ile Arg Phe 
385                 390                 395                 400 


Leu Asp Glu Phe Phe Asp Phe Pro Thr Leu Arg Phe Gln Val His Leu 
                405                 410                 415     


Gly Asp Tyr Val His Asp Arg Arg Thr Lys Gln Leu Gly Lys Val Glu 
            420                 425                 430         


Ser Asp Arg Ile Ile Lys Glu Lys Val Thr Val Phe Ala Arg Leu Lys 
        435                 440                 445             


Asp Ile Asn Ser Ala Lys Ala Ser Tyr Phe His Ser Leu Glu Glu Gln 
    450                 455                 460                 


Asp Lys Glu Glu Leu Asp Asn Lys Trp Thr Leu Phe Pro Asn Pro Ser 
465                 470                 475                 480 


Tyr Asp Phe Pro Lys Glu His Thr Leu Gln His Gln Gly Glu Gln Lys 
                485                 490                 495     


Asn Ala Gly Lys Ile Gly Ile Tyr Val Lys Leu Arg Asp Thr Gln Tyr 
            500                 505                 510         


Lys Glu Lys Ala Ala Leu Glu Glu Ala Arg Lys Ser Leu Asn Pro Lys 
        515                 520                 525             


Glu Arg Ser Ala Thr Lys Ala Ser Lys Tyr Asp Ile Ile Thr Gln Ile 
    530                 535                 540                 


Ile Glu Ala Asn Asp Asn Val Lys Ser Glu Lys Pro Leu Val Phe Thr 
545                 550                 555                 560 


Gly Gln Pro Ile Ala Tyr Leu Ser Met Asn Asp Ile His Ser Met Leu 
                565                 570                 575     


Phe Ser Leu Leu Thr Asp Asn Ala Glu Leu Lys Lys Thr Pro Glu Glu 
            580                 585                 590         


Val Glu Ala Lys Leu Ile Asp Gln Ile Gly Lys Gln Ile Asn Glu Ile 
        595                 600                 605             


Leu Ser Lys Asp Thr Asp Thr Lys Ile Leu Lys Lys Tyr Lys Asp Asn 
    610                 615                 620                 


Asp Leu Lys Glu Thr Asp Thr Asp Lys Ile Thr Arg Asp Leu Ala Arg 
625                 630                 635                 640 


Asp Lys Glu Glu Ile Glu Lys Leu Ile Leu Glu Gln Lys Gln Arg Ala 
                645                 650                 655     


Asp Asp Tyr Asn Tyr Thr Ser Ser Thr Lys Phe Asn Ile Asp Lys Ser 
            660                 665                 670         


Arg Lys Arg Lys His Leu Leu Phe Asn Ala Glu Lys Gly Lys Ile Gly 
        675                 680                 685             


Val Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Phe Lys Glu Ser Lys 
    690                 695                 700                 


Ser Lys Trp Lys Gly Tyr Gln His Thr Glu Leu Gln Lys Leu Phe Ala 
705                 710                 715                 720 


Tyr Phe Asp Thr Ser Lys Ser Asp Leu Glu Leu Ile Leu Ser Asp Met 
                725                 730                 735     


Val Met Val Lys Asp Tyr Pro Ile Glu Leu Ile Asp Leu Val Arg Lys 
            740                 745                 750         


Ser Arg Thr Leu Val Asp Phe Leu Asn Lys Tyr Leu Glu Ala Arg Leu 
        755                 760                 765             


Gly Tyr Ile Glu Asn Val Ile Thr Arg Val Lys Asn Ser Ile Gly Thr 
    770                 775                 780                 


Pro Gln Phe Lys Thr Val Arg Lys Glu Cys Phe Ala Phe Leu Lys Glu 
785                 790                 795                 800 


Ser Asn Tyr Thr Val Ala Ser Leu Asp Lys Gln Ile Glu Arg Ile Leu 
                805                 810                 815     


Ser Met Pro Leu Phe Ile Glu Arg Gly Phe Met Asp Ser Lys Pro Thr 
            820                 825                 830         


Met Leu Glu Gly Lys Ser Tyr Gln Gln His Lys Glu Asp Phe Ala Asp 
        835                 840                 845             


Trp Phe Val His Tyr Lys Glu Asn Ser Asn Tyr Gln Asn Phe Tyr Asp 
    850                 855                 860                 


Thr Glu Val Tyr Glu Ile Ile Thr Glu Asp Lys Arg Glu Gln Ala Lys 
865                 870                 875                 880 


Val Thr Lys Lys Ile Lys Gln Gln Gln Lys Asn Asp Val Phe Thr Leu 
                885                 890                 895     


Met Met Val Asn Tyr Met Leu Glu Glu Val Leu Lys Leu Pro Ser Asn 
            900                 905                 910         


Asp Arg Leu Ser Leu Asn Glu Leu Tyr Gln Thr Lys Glu Glu Arg Ile 
        915                 920                 925             


Val Asn Lys Gln Val Ala Lys Asp Thr Gln Glu Arg Asn Lys Asn Tyr 
    930                 935                 940                 


Ile Trp Asn Lys Val Val Asp Leu Gln Leu Cys Glu Gly Leu Val Arg 
945                 950                 955                 960 


Ile Asp Lys Val Lys Leu Lys Asp Ile Gly Asn Phe Arg Lys Tyr Glu 
                965                 970                 975     


Asn Asp Ser Arg Val Lys Glu Phe Leu Thr Tyr Gln Ser Asp Ile Val 
            980                 985                 990         


Trp Ser Ala Tyr Leu Ser Asn Glu  Val Asp Ser Asn Lys  Leu Tyr Val 
        995                 1000                 1005             


Ile Glu  Arg Gln Leu Asp Asn  Tyr Glu Ser Ile Arg  Ser Lys Glu 
    1010                 1015                 1020             


Leu Leu  Lys Glu Val Gln Glu  Ile Glu Cys Ser Val  Tyr Asn Gln 
    1025                 1030                 1035             


Val Ala  Asn Lys Glu Ser Leu  Lys Gln Ser Gly Asn  Glu Asn Phe 
    1040                 1045                 1050             


Lys Gln  Tyr Val Leu Gln Gly  Leu Leu Pro Ile Gly  Met Asp Val 
    1055                 1060                 1065             


Arg Glu  Met Leu Ile Leu Ser  Thr Asp Val Lys Phe  Lys Lys Glu 
    1070                 1075                 1080             


Glu Ile  Ile Gln Leu Gly Gln  Ala Gly Glu Val Glu  Gln Asp Leu 
    1085                 1090                 1095             


Tyr Ser  Leu Ile Tyr Ile Arg  Asn Lys Phe Ala His  Asn Gln Leu 
    1100                 1105                 1110             


Pro Ile  Lys Glu Phe Phe Asp  Phe Cys Glu Asn Asn  Tyr Arg Ser 
    1115                 1120                 1125             


Ile Ser  Asp Asn Glu Tyr Tyr  Ala Glu Tyr Tyr Met  Glu Ile Phe 
    1130                 1135                 1140             


Arg Ser  Ile Lys Glu Lys Tyr  Ala Asn 
    1145                 1150         


<210>  2020
<211>  1107
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2020

Met Glu Thr Ile Glu Lys Thr Glu His Lys Gly Leu Asn Val Tyr Lys 
1               5                   10                  15      


Thr Val Glu Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala 
            20                  25                  30          


Arg Leu Asn Ile Phe Ser Ile Asn Asn Ser Val Ala His Lys Ile Lys 
        35                  40                  45              


Leu Pro Thr Leu Ser Asp Glu Glu Lys Ile Leu Asp Ser Phe Leu Cys 
    50                  55                  60                  


Thr Asn Asn Arg Lys His Leu Asn Trp Asn Leu Ala His Ser Ile Ala 
65                  70                  75                  80  


Val Lys Phe Leu Pro Ile Val Lys Val Phe Asp Phe Glu Ser Leu Pro 
                85                  90                  95      


Lys Gln Glu Arg Thr Gly Asp Leu Asn Asn Arg Asn Ala Gly Lys Asp 
            100                 105                 110         


Phe Ala Ala Met Thr Ala Ser Leu Arg Cys Leu Phe Ser Glu Ile Gln 
        115                 120                 125             


Glu Phe Arg Asn Asp Tyr Ser His Tyr Tyr Ser Ile Ala Asn Gly Asp 
    130                 135                 140                 


Lys Arg Lys Thr Thr Ile Ser Gly Glu Ala Ala Glu Phe Leu Arg Leu 
145                 150                 155                 160 


Asn Phe Ala Arg Ala Ile Glu Tyr Thr Lys Glu Arg Phe Asn Gly Val 
                165                 170                 175     


Leu Asn Asp Glu Asp Phe Glu Pro Ala Lys Glu Arg Val Leu Val Asn 
            180                 185                 190         


Gln Asp Asn Thr Ile Thr Thr Asp Gly Phe Val Phe Leu Ile Ser Met 
        195                 200                 205             


Phe Leu Glu Arg Glu His Ala Phe Gln Phe Ile Gly Lys Ile Lys Gly 
    210                 215                 220                 


Leu Lys Gly Thr Gln Phe Asn Ser Phe Ile Ala Thr Arg Glu Val Leu 
225                 230                 235                 240 


Met Ala Phe Cys Val Lys Leu Pro His Asp Arg Phe Val Ser Glu Asp 
                245                 250                 255     


Lys Lys Gln Ala Leu Thr Leu Asp Ile Ile Asn Thr Leu Asn Arg Cys 
            260                 265                 270         


Pro Lys Glu Leu Tyr Ser Val Ile Thr Asp Glu Glu Arg Lys Ala Phe 
        275                 280                 285             


Lys Pro Gly Leu Asp Ser Leu Lys Leu Glu Asn Leu Leu Asp Asn Ser 
    290                 295                 300                 


Thr Asn Asp Lys Ala Ala Ile Glu Asp Tyr Asp Lys Tyr Ile Glu Ala 
305                 310                 315                 320 


Leu Thr Arg Lys Ile Arg His Ser Asn Arg Phe Ser Tyr Phe Ala Leu 
                325                 330                 335     


Lys Phe Ile Asp Glu Thr Asp Ile Phe Ser Lys Leu Arg Phe Gln Val 
            340                 345                 350         


Asn Leu Gly Lys Leu Leu Ile Asp Glu Tyr Glu Lys Pro Val Asn Asn 
        355                 360                 365             


Glu Leu Tyr Pro Arg Ser Ile Val Gln Asn Val Lys Ala Phe Gly Lys 
    370                 375                 380                 


Leu Asn Asp Phe Glu Glu Glu Ala Glu Val Leu Lys Gln Ile Asp Lys 
385                 390                 395                 400 


Asp Gly Asn Ser Leu Gly Phe Glu Gln Tyr Ala Pro Phe Tyr Ser Thr 
                405                 410                 415     


Lys Asn Asn Lys Ile Gly Leu His Thr Asn Ser Ala Lys Ser Ile Ile 
            420                 425                 430         


Ile Asn Arg Pro Asn Ser Glu Ser Lys Ile Lys Lys Asn Leu Lys Gln 
        435                 440                 445             


Ala Leu Pro Glu Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile 
    450                 455                 460                 


Val Leu Glu His Leu Lys Lys Gly Lys Pro Glu Glu Leu Ile Asn Asp 
465                 470                 475                 480 


Phe Ile Leu Ala Cys Asn Ser Lys Ile Thr Asn Lys Gln Phe Ile Asp 
                485                 490                 495     


Glu Val Lys Ala Lys Leu Pro Asn Asp Trp Asn Glu Phe Asn Lys Arg 
            500                 505                 510         


Ser Asp Ser Lys Lys Asp Pro Ala Tyr Lys Pro Asn Ala Leu Ala Tyr 
        515                 520                 525             


Leu Arg Lys Arg Lys Lys Thr Leu Asp Glu Val Leu Ala Gln Tyr Asn 
    530                 535                 540                 


Leu Asn His Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp Leu Cys 
545                 550                 555                 560 


Ile Val Asp Ile Asp Glu Asn Arg Ala Ile Ser Glu Arg Ile Lys Arg 
                565                 570                 575     


Met Lys Arg Glu Gly Met Asp Arg Leu Lys Ala Tyr Gln Lys Phe Thr 
            580                 585                 590         


Lys Thr Gly Lys Gly Lys Ile Pro Lys Ile Gly Glu Met Ala Thr Phe 
        595                 600                 605             


Leu Ala Lys Asp Ile Val Asp Met Val Ile Ser Thr Asp Lys Lys Lys 
    610                 615                 620                 


Lys Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu 
625                 630                 635                 640 


Phe Ala Asp Pro Glu Lys Lys Thr Leu Phe Ile Asp Leu Ile Ser Lys 
                645                 650                 655     


Glu Leu Met Leu Asn Asp Ile Gly Gly His Pro Phe Leu Lys Asn Ile 
            660                 665                 670         


Arg Phe Lys Asn Leu Asn Tyr Leu Gln Asp Leu Tyr Ala Lys Tyr Leu 
        675                 680                 685             


Gln Glu Lys Val Lys Arg Asn Ala Tyr Asn Asp Asp Ser Trp Met Asn 
    690                 695                 700                 


Thr Thr Phe Tyr Asp Leu Ala Trp Asp Asp Lys Lys Gly Lys Glu Ser 
705                 710                 715                 720 


Thr Thr Val Arg Ile Pro Phe Asn Leu Ser Asn Val Pro Phe Thr Leu 
                725                 730                 735     


Arg Gln Leu Lys Glu Lys Thr Asn Tyr Asn Leu Asp Glu Trp Leu Tyr 
            740                 745                 750         


Asn Val Thr Lys Gly Lys Val Lys Gly Asp Gly Lys Ala Pro Ile Asn 
        755                 760                 765             


Leu Pro Thr Asn Leu Phe Asp Glu Thr Leu Thr Arg Leu Leu Gln Asn 
    770                 775                 780                 


Asn Leu Glu Ala His Ala Val Glu Tyr Pro Ala Glu Ala Lys Tyr Asn 
785                 790                 795                 800 


Glu Leu Phe Lys Ile Trp Trp Lys Lys Arg Gly Asp Ser Thr Gln Ser 
                805                 810                 815     


Phe Tyr Asn Ala Glu Arg Glu Tyr Phe Ile Phe Asp Glu Lys Val Asn 
            820                 825                 830         


Phe Lys Leu Gln Glu Asn Ala Met Phe Ala Asp Phe Tyr Ser Asp Ser 
        835                 840                 845             


Val Lys Lys Ala Phe Arg Ala Lys Arg Asn Ala Arg Arg Ile Glu Gln 
    850                 855                 860                 


Arg Thr Asp Arg Ser Leu Pro Asp Ile Lys Phe Ser Gln Val Glu Lys 
865                 870                 875                 880 


Val Phe Lys Arg Ser Ile Ser Asn Ser Glu Lys Gln Ile Arg Leu Leu 
                885                 890                 895     


Gln Glu Glu Asp Arg Ile Met Leu Leu Met Leu Glu Lys Leu Met Thr 
            900                 905                 910         


Pro Asn Gln Asp Leu Asn Leu Lys Leu Asn Gln Ile Asp Thr Leu Leu 
        915                 920                 925             


Asn Lys Ile Ile Thr Val Lys Glu Leu Val Thr Gly Lys Leu Tyr Phe 
    930                 935                 940                 


Glu Asn Asn Ala Glu Ile Thr Lys Thr Ile Val Asp Arg Arg Lys Arg 
945                 950                 955                 960 


Lys Asp Phe Ser Met Leu His Lys Tyr Val Phe Asp Arg Arg Leu Pro 
                965                 970                 975     


Glu Leu Phe Glu Tyr Phe Glu Glu Asn Glu Ile Pro Leu Pro Asn Leu 
            980                 985                 990         


Lys Asn Glu Leu Glu Ala Tyr Asn  Ala Ala Lys Gln Lys  Val Leu Asp 
        995                 1000                 1005             


Ala Ala  Phe Glu Leu Glu Lys  Lys Leu Leu Ala Asn  Asn Arg Ala 
    1010                 1015                 1020             


Asp Asn  Phe Ile Asp Glu Asp  Cys Lys Asn Gly His  Ile Pro His 
    1025                 1030                 1035             


Lys Ala  Tyr Leu Gln Trp Leu  Thr Lys Glu Gly Val  Ile Asn Glu 
    1040                 1045                 1050             


Asn Glu  Phe Leu Phe Leu Asn  Gly Val Arg Asn Cys  Phe Ser His 
    1055                 1060                 1065             


Asn Leu  Phe Pro Gln Lys Arg  Thr Met Ser Leu Phe  Val Ala Arg 
    1070                 1075                 1080             


Trp Asp  Asn Ser Asn Phe Ala  Gln Gln Ile Ala Glu  Arg Tyr Asn 
    1085                 1090                 1095             


Glu Lys  Ile Asp Ala Ile Leu  Ala Ile 
    1100                 1105         


<210>  2021
<211>  1057
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2021

Met Thr Ile Lys Glu Gln Ser His Phe Ala Ala Tyr Tyr Asn Met Ala 
1               5                   10                  15      


Arg His Asn Met Tyr Glu Thr Leu Cys Tyr Ile Ser Lys Ile Ser Gly 
            20                  25                  30          


Ile Gln Glu Gly Glu Asp Asn Lys Glu Ser Lys Ile Glu Asp Met Gln 
        35                  40                  45              


Leu Leu Arg Val Leu Thr Thr Lys Gly His Pro Glu Glu Lys Ile Arg 
    50                  55                  60                  


Ile Glu Lys Leu Ile Tyr Lys His Leu Pro Leu Phe Arg Pro Ala Val 
65                  70                  75                  80  


Glu Asp Leu Arg Lys Lys Ser Lys Glu Asn Val Lys Ser Pro Glu Leu 
                85                  90                  95      


Leu Ala Lys Val Ile Lys Asn Trp Ala Lys Val Ile Thr Tyr Tyr Arg 
            100                 105                 110         


Asp Lys Phe Thr His Tyr Val Phe Ile Asp Lys Arg His Glu Asn Lys 
        115                 120                 125             


Glu Phe Leu Asn Ala Glu Met Ser Val Ala Asn Asp Leu Asn Gln Ile 
    130                 135                 140                 


Phe Thr Ala Ser Ala Arg Val Ile Lys Glu Arg Phe Gly Leu Ser Thr 
145                 150                 155                 160 


Glu Leu Glu Phe Leu Thr Lys Gly Arg Tyr Arg Thr Gln Thr Ile Asp 
                165                 170                 175     


Gly Lys Arg Ser Thr Lys Leu Asn Pro Asn Phe Ile Tyr Ser Leu Gln 
            180                 185                 190         


Asp Lys Asn Glu Arg Leu Asn Lys Met Gly Leu Ile Phe Leu Ala Cys 
        195                 200                 205             


Gln Leu Ile Glu Lys Lys Tyr Ala Ser Met Leu Phe Asp Gln Gln Gly 
    210                 215                 220                 


Tyr Met Gly Arg Asp Ile Tyr Phe Asp Phe Thr Pro Ala Gln Cys Lys 
225                 230                 235                 240 


Tyr Ile Arg Glu Val Phe Ser Ala His Arg Ile Val Leu Pro Arg Gly 
                245                 250                 255     


Arg Met Asp Val Glu Arg Asn Glu Ile Thr Ile Ala Met Asp Met Phe 
            260                 265                 270         


Asn Glu Leu Gly Lys Cys Pro Lys Glu Leu Phe Glu Ile Ile Ser Lys 
        275                 280                 285             


Glu Glu Gln Lys Arg Phe Arg Thr Lys Ser Glu Thr Thr Gly Glu Glu 
    290                 295                 300                 


Val Leu Leu Met Arg His Ser Asp Arg Phe Ala Thr Leu Ala Leu Gln 
305                 310                 315                 320 


Tyr Ile Asp Asn Arg Lys Val Phe Glu Lys Ile Arg Phe Gln Leu Ser 
                325                 330                 335     


Leu Gly Lys Tyr Arg Tyr Lys Phe Tyr Asp Lys Thr Cys Val Asp Gly 
            340                 345                 350         


Asp Thr His Val Arg Ile Leu Gln Lys Glu Leu Asn Gly Phe Gly Arg 
        355                 360                 365             


Ile Asn Glu Ile Glu Leu Leu Lys Glu Glu Lys Trp Gly Gly Leu Ile 
    370                 375                 380                 


Arg Lys Phe Glu Asp Ala Lys Ile Asp Thr Ala Glu Thr Lys Pro Tyr 
385                 390                 395                 400 


Ile Thr Asp Gln Tyr Pro Gln Tyr Leu Phe Asn Gly Asn Arg Ile Gly 
                405                 410                 415     


Ile Tyr Phe Asn Ser Ala His Gly Lys Ala Met Arg Asn Gly Ala Tyr 
            420                 425                 430         


Ile Pro Asp Ile Glu Ser Gly Ala His Cys Ile Gln Pro Ile Cys Trp 
        435                 440                 445             


Ile Ser Asn Tyr Glu Leu Pro Ala Leu Ile Phe His His Ile Leu Thr 
    450                 455                 460                 


Lys Asp Glu Lys Lys Ser Leu Thr Glu Lys Ile Ile Ile Asp Cys Val 
465                 470                 475                 480 


Glu Arg Tyr Lys Lys Leu Phe Asn Asp Ile Ala Glu Gly Lys Val Ala 
                485                 490                 495     


Arg Thr Gly Asn Ala Thr Ser Asp Phe Glu Met Ile Ser Lys Glu Tyr 
            500                 505                 510         


Gly Ile Glu Lys Ser Asp Ile Pro Arg Glu Leu Gln Asp Tyr Phe Asn 
        515                 520                 525             


Gly Thr Glu Arg Asp Gly Ile Glu Gln Tyr Ala Lys Ala Gln Ile Arg 
    530                 535                 540                 


Glu Met Ile Glu Glu Asn Arg Ile Arg Leu Glu Gln Phe Asn Ser Lys 
545                 550                 555                 560 


Leu Lys Lys Ile Glu Asp Gly Glu Val Lys Tyr Gly Lys Arg Asp Tyr 
                565                 570                 575     


Thr Glu Ile Arg Thr Gly Glu Leu Ala Gln Tyr Leu Ala Lys Asp Ile 
            580                 585                 590         


Val Met Phe Met Pro Lys Ala Lys Tyr Lys Pro Thr Ser Lys Asn Tyr 
        595                 600                 605             


Asn Val Met Gln Ala Leu Leu Ala Thr Phe Asn Gly Ser Glu Ser Gly 
    610                 615                 620                 


Ser Thr Leu Asp Glu Val Asp Asp Met Phe Asp Asn Ile Lys Ala Cys 
625                 630                 635                 640 


Tyr Trp Lys Asn Glu Ser Asp Asn His Pro Phe Leu Glu Tyr Val Leu 
                645                 650                 655     


Gly Glu Glu Pro Lys Asp Ile Ile Ala Phe Tyr Lys Ile Tyr Leu Glu 
            660                 665                 670         


Leu Arg Gly Glu Tyr Leu Asp Lys Cys Ile Lys Lys Met Asp Leu Ala 
        675                 680                 685             


Thr Ile Pro Phe Ile His Thr Glu Arg Lys Arg Trp Glu Lys Arg Asp 
    690                 695                 700                 


Glu Lys Phe Phe Lys Glu Leu Ala Gln Arg Tyr Ala Thr Gln Pro Ile 
705                 710                 715                 720 


Glu Leu Pro Arg Gly Leu Tyr Asp Arg Ala Ile Lys Glu Tyr Leu Lys 
                725                 730                 735     


Ser Lys Ser Ile Leu Glu Asp Val Ile Ala Gln Glu Gln Cys Asn Val 
            740                 745                 750         


Thr Tyr Leu Ile Ala Arg Tyr Met Gln Asp Val Leu Lys Asp Asp Ser 
        755                 760                 765             


Gln Gln Phe Tyr Ser Leu Pro Arg His Tyr Ser Cys Leu Ser Glu Lys 
    770                 775                 780                 


Asp Lys Tyr Leu Ser Leu Thr Glu Arg Glu Ala Ile Ala Lys Ser Asp 
785                 790                 795                 800 


Ala Leu Asn Ser Phe Lys Lys Arg Glu Arg Glu Lys Glu Asn Glu Asn 
                805                 810                 815     


Arg Arg Gly Asn Arg Arg Tyr Asn Lys Gly Glu Asn Lys Asn Thr Ile 
            820                 825                 830         


Lys Asp Arg Asp Thr Glu Glu Lys Phe Asn Ser Leu Tyr Arg Lys Met 
        835                 840                 845             


Asp Asn Asn Glu Arg Ile Leu Arg Arg Tyr Lys Val Gln Asp Met Leu 
    850                 855                 860                 


Leu Tyr Leu Leu Ala Cys Asp Ile Ile Lys Gly Ile Met Arg Glu Asp 
865                 870                 875                 880 


Phe Gly Tyr Lys Leu Ser Met Ile Thr Asp Gly Lys Asn Ser Asn Phe 
                885                 890                 895     


Phe Asp Tyr Lys Met Pro Glu Phe Lys Thr Thr Ile Thr Leu Lys Glu 
            900                 905                 910         


Gly Lys Lys Phe Thr Ile Lys Gln Gln Tyr Leu Lys Ile Lys Asn Tyr 
        915                 920                 925             


Gly Asp Phe Leu Lys Phe Ile Phe Asp Leu Arg Ile Asp Ser Leu Leu 
    930                 935                 940                 


Ser Asn Gly Thr Lys Val Glu Ile Asp Arg Asn Ile Leu Glu Asp Glu 
945                 950                 955                 960 


Leu Ser Asn Tyr Asp Gly Ser Arg Pro Lys Val Phe Glu Thr Leu Leu 
                965                 970                 975     


Met Ile Glu Lys Ile Val Val Glu Lys His Lys Glu Leu Lys Asp Leu 
            980                 985                 990         


Glu His Ile Thr Phe Gly Asp Val  Leu Asn Val Ile Lys  Met Glu Glu 
        995                 1000                 1005             


Gly Glu  Lys Lys Ile Leu Arg  Leu Ile Arg Asn Ala  Phe Ser His 
    1010                 1015                 1020             


Asn Tyr  Tyr Pro Thr Ile Lys  Asp Val Asn Tyr Asp  Asn Met Pro 
    1025                 1030                 1035             


Glu Val  Ala Glu Ser Leu Lys  Asp Ile Leu Glu Lys  Glu Ser Lys 
    1040                 1045                 1050             


Lys Leu  Thr Asn 
    1055         


<210>  2022
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2022

Met Gly Ala Ile Lys Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2023
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2023

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2024
<211>  1134
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2024

Met Asn Glu Thr Asp Tyr Leu Ala Lys Arg Leu Glu Tyr Asn Tyr Ala 
1               5                   10                  15      


Ser Ile Glu Asp Lys His Tyr Phe Gly Gly Tyr Phe Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asn Asp Leu Ser Lys Ala Phe Lys Glu Lys Phe Gly Met 
        35                  40                  45              


Lys Pro Lys Ser Cys Ile Leu Asp Phe Phe Thr Gln Asp Lys Ala Ile 
    50                  55                  60                  


Ala Glu Tyr Gln Leu Gly Val Glu Phe Leu Gln Lys Asn Leu Pro Val 
65                  70                  75                  80  


Ile Arg Tyr Leu Tyr Leu Pro Thr Ser His Lys Arg Phe Glu Asn Val 
                85                  90                  95      


Pro Lys Asn Gln Leu Ile Ser Glu Gln Arg Asn Tyr Phe Lys Asn Ser 
            100                 105                 110         


Leu Lys Val Leu Lys Asn Leu Ile Arg Asp Tyr Arg Asn Phe Tyr Thr 
        115                 120                 125             


His His Phe His Lys Pro Ile Pro Val Phe Pro Glu Thr Tyr Lys Leu 
    130                 135                 140                 


Leu Asp Asp Leu Phe Leu Ala Val Ala Asn Asp Val Lys Lys His Arg 
145                 150                 155                 160 


Met Lys Thr Asp Ala Ser Lys Gln Leu Leu Lys Lys Gly Leu Ile Glu 
                165                 170                 175     


Glu Leu Ala Gln Leu Glu Lys Leu Lys Leu Glu Asp Leu Lys Lys Leu 
            180                 185                 190         


Lys Arg Glu Gly Lys Lys Val Asn Leu Asn Asp Lys Glu Ala Ile Thr 
        195                 200                 205             


Asn Ala Ile Leu Asn Asp Ser Phe Ser His Leu Leu Pro Lys Glu Asn 
    210                 215                 220                 


Thr Ile Ser Lys Tyr Tyr Ser Ala Val Pro Thr Glu Asp Ile Asp Thr 
225                 230                 235                 240 


Glu Asn Gly Val Thr Ile Ser Glu Ser Gly Ile Ile Phe Leu Leu Gly 
                245                 250                 255     


Leu Phe Leu Thr Lys Lys Gln Ser Glu Asp Leu Arg Ser Arg Val Lys 
            260                 265                 270         


Gly Phe Lys Ala Lys Leu Ile Val Asn Pro Glu Asn Pro Ile Asn Lys 
        275                 280                 285             


Lys Asn Asn Ser Leu Lys Tyr Met Ala Thr His Trp Val Phe Gly Tyr 
    290                 295                 300                 


Leu Gly Phe Lys Gly Leu Lys Asn Arg Phe Thr Thr Thr Phe Thr Lys 
305                 310                 315                 320 


Asp Thr Leu Leu Ala Gln Ile Val Asp Glu Leu Ser Lys Val Pro Asp 
                325                 330                 335     


Glu Leu Tyr Gln Val Leu Pro Glu Glu Leu Lys Asn Glu Phe Leu Glu 
            340                 345                 350         


Asp Met Asn Glu Tyr Leu Lys Glu Glu Asn Ser Glu Ser Leu Asp Lys 
        355                 360                 365             


Ala Thr Val Ile His Pro Val Ile Arg Lys Arg Tyr Glu Asn Lys Phe 
    370                 375                 380                 


Ala Tyr Phe Ala Leu Arg Phe Leu Asp Glu Phe Val Asp Phe Pro Thr 
385                 390                 395                 400 


Leu Arg Phe Gln Leu His Leu Gly Asn Tyr Val His Asp Lys Arg Glu 
                405                 410                 415     


Lys Pro Ile Glu Gly Thr Lys Tyr Val Thr Glu Arg Ile Val Lys Glu 
            420                 425                 430         


Lys Ile Lys Ala Phe Ala Lys Leu Ser Glu Ala Ala Gln Leu Lys Gln 
        435                 440                 445             


Lys Tyr Phe Glu Glu Lys Glu Asn His Gln Ser Ile Gly Leu Gln Leu 
    450                 455                 460                 


Tyr Pro Asn Pro Ser Tyr Asn Phe Val Gly Asn Asn Ile Pro Ile His 
465                 470                 475                 480 


Leu Asn Leu Asn Glu His Phe Phe Pro Lys Glu Val Lys Ile Val Ala 
                485                 490                 495     


Gly Arg Leu Lys Lys Arg Asn Ser Ser Tyr Lys Ser Asp His Pro Glu 
            500                 505                 510         


Glu Tyr Lys Val Arg Thr Asp Asn Lys Ile Lys Pro Asp Ala Ile Leu 
        515                 520                 525             


Gln Asp Leu Gly Lys Pro Glu Lys Leu Ala Pro Val Ala Met Leu Ser 
    530                 535                 540                 


Leu Asn Glu Leu Pro Ala Leu Leu His Leu Val Leu Thr Lys Lys Thr 
545                 550                 555                 560 


Pro Glu Glu Ile Glu Ile Ile Ile Ala Gln Lys Ile Ala Glu Arg Tyr 
                565                 570                 575     


Asn Val Leu Thr Asn Tyr Lys Ala Gly Asp Asp Ile Ser Lys Gly Gln 
            580                 585                 590         


Ile Thr Lys Asn Leu Leu Lys Ala Lys Gln Lys Lys Glu Val Asn Leu 
        595                 600                 605             


Asp Lys Leu Gln Leu Ala Ile Glu Lys Glu Ile Ala Val Thr Asn Asp 
    610                 615                 620                 


Lys Leu Gln Thr Ile Ala Leu His Ile Lys Glu Arg Asn Asp Pro Lys 
625                 630                 635                 640 


Gln Lys Arg Lys Tyr Val Phe Thr Asn Lys Glu Ile Gly Leu Gln Val 
                645                 650                 655     


Thr Trp Leu Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Gly Ser Arg 
            660                 665                 670         


Gln Asn Trp Arg Gly Gln His His Ser Gln Leu Gln Lys Ser Leu Ala 
        675                 680                 685             


Phe Tyr Asp Ile Gln Pro Lys Glu Pro Leu Ser Leu Leu Glu Glu Val 
    690                 695                 700                 


Trp Asp Phe Lys Asn Glu Ala Tyr Leu Trp Asn Asn Gly Ile Arg Arg 
705                 710                 715                 720 


Ser Phe Asp Lys Arg Asp Phe Ile Ser Phe Tyr Thr Ser Tyr Leu Asn 
                725                 730                 735     


Asn Arg Lys Glu Thr Phe Gln Arg Phe Lys Asp Gln Leu Asn Gly Ile 
            740                 745                 750         


Arg Ser Asn Lys Lys Ile Leu Asp Lys Phe Ile Lys Gln Gln His Leu 
        755                 760                 765             


Trp Asn Leu Phe His Lys Arg Leu Tyr Val Ile Asp Thr Ile Glu Glu 
    770                 775                 780                 


Gln Val Glu Lys Leu Leu Val Lys Pro Met Gln Phe Pro Lys Gly Val 
785                 790                 795                 800 


Phe Asp His Lys Pro Thr Tyr Ile Lys Gly Lys Ser Ile Gln Glu Asn 
                805                 810                 815     


Pro Glu Cys Phe Ala Asp Trp Tyr Val Ala Trp Asn Gln His Thr Asp 
            820                 825                 830         


Tyr Gln Lys Phe Tyr Ser Trp Asp Arg Asp Tyr Lys Ser Ala Tyr Leu 
        835                 840                 845             


Ser Gly Glu Gln Glu Lys Thr Glu Lys Arg Phe Ile Arg Val Gln Gly 
    850                 855                 860                 


Ser Lys Ile Asn Lys Val Lys Gln Gln Asp Val Leu Leu Ala Lys Met 
865                 870                 875                 880 


Ala Ser Ile Ile Phe Asn Glu Leu Tyr Leu Pro Glu Asp Ala Glu His 
                885                 890                 895     


Leu Asp Leu Asn Leu Ser Asp Ile Tyr Lys Thr Gln Thr Glu Arg Lys 
            900                 905                 910         


Ala Glu Ile Glu Ala Ala Leu Ile Gln Ser His Lys Thr Thr Gly Asp 
        915                 920                 925             


Asn Ser Ala Asn Ile Ile Lys Ser Thr Ser Ala Trp Thr Leu Thr Val 
    930                 935                 940                 


Pro Tyr Cys Ser Lys Asn Ile Tyr Glu Pro Gln Val Lys Leu Lys Glu 
945                 950                 955                 960 


Leu Gly Lys Phe Lys Lys Phe Ile Ala Ser Gln Lys Val Gln Thr Leu 
                965                 970                 975     


Phe Glu Tyr Lys Pro Gln Lys Ile Trp Asn Lys Thr Glu Leu Glu Glu 
            980                 985                 990         


Val Leu Glu Leu Lys Ala Asn Ser  Tyr Glu Val Ile Arg  Arg Asp Tyr 
        995                 1000                 1005             


Leu Leu  Lys Ser Ile Gln Glu  Phe Glu Lys Tyr Met  Ile Lys Lys 
    1010                 1015                 1020             


Leu Pro  Thr Leu Ile Asp Thr  Asn Glu His Pro Asn  Phe Asn Lys 
    1025                 1030                 1035             


Tyr Leu  Thr Thr Phe Leu Lys  Ser Leu Glu Leu Val  Ser Glu Glu 
    1040                 1045                 1050             


Asp Ala  Lys Trp Leu Ile Ser  Lys Lys Asp Phe Asp  Thr Thr Pro 
    1055                 1060                 1065             


Ile Asp  Glu Leu Lys Lys Gln  Ser Lys Ile Met Glu  Lys Ala Phe 
    1070                 1075                 1080             


Leu Leu  Val Met Ile Arg Asn  Lys Phe Ser His Asn  Gln Leu Pro 
    1085                 1090                 1095             


Arg Lys  Ile Tyr Tyr Asp Glu  Ile Tyr Lys Asn Val  Pro Asn Ala 
    1100                 1105                 1110             


Val Ser  Ile Asn Phe Asn Glu  Leu Phe Leu Glu Tyr  Thr Asn Gln 
    1115                 1120                 1125             


Thr Ile  Leu Glu Phe Lys 
    1130                 


<210>  2025
<211>  1167
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2025

Met Asn Lys Ala Ile Phe Gly Ala Tyr Leu Asn Ala Ala Gln His Asn 
1               5                   10                  15      


Ala Tyr Met Ile Leu Asn His Ile Lys Asp Leu Val Thr Leu Lys Asp 
            20                  25                  30          


Lys Asn Asn Thr Ala Gly Ala Asp Val Glu Glu Ser Arg Leu Asp Asn 
        35                  40                  45              


Ile Asn Ile Leu Gln Leu Lys Asn Ala Pro Glu Lys Ile Ala Tyr Thr 
    50                  55                  60                  


Leu Lys Leu Leu Tyr Leu His Phe Pro Phe Leu Gly Met Leu Val Pro 
65                  70                  75                  80  


Glu Asn Ile Asn Ser Val Glu Asn Asn Tyr Glu Lys Val Ala Arg Ile 
                85                  90                  95      


Leu Lys Lys Ala Leu Val Arg Leu Asn Gln Glu Arg Asn Gln Tyr Ser 
            100                 105                 110         


His Tyr Glu Thr Gln Thr Leu Lys Thr Glu Ser His Phe Val Leu Ala 
        115                 120                 125             


Ser Thr Gln Lys Asp Leu Asp Leu Asp Glu Leu Arg Ser Thr Phe Leu 
    130                 135                 140                 


Asn Trp Phe Asn Leu Asp Asn Pro Asn Lys Glu Arg Ala Phe Ala Arg 
145                 150                 155                 160 


Tyr Pro Phe Met Asp Gly Glu Ala Arg Asn Phe Met Gly Leu His Ile 
                165                 170                 175     


Ala Lys Asn Ser Leu Trp Lys Asn Ser Ser Glu Ala Gly Lys Asp Phe 
            180                 185                 190         


Ser Glu Lys Gly Leu Ile Tyr Phe Leu Cys Leu Phe Leu Glu Arg Lys 
        195                 200                 205             


Gln Ala Tyr Leu Leu Leu Asn Ser Ile Gln Gly Phe Lys Gly Ser Lys 
    210                 215                 220                 


Gly Asn Lys Phe Arg Ala Val Arg Glu Met Tyr Ala His Asn Cys Cys 
225                 230                 235                 240 


Lys Leu Pro Gln Pro Arg Leu Asp Ser Ser Asp Ile Leu Leu Asp Met 
                245                 250                 255     


Leu Asn Glu Leu Asn Arg Cys Pro Lys Asp Leu Phe Gln Val Leu Gly 
            260                 265                 270         


Glu Thr Asp Gln Gln Arg Phe Met Ser Ala Ile Asp Asn Ala Ser Ala 
        275                 280                 285             


Val Val Lys Arg Gln Asp Asp Asn Gly Glu Leu Leu Glu Tyr Glu Lys 
    290                 295                 300                 


Arg Ile Arg His Gln Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe 
305                 310                 315                 320 


Asp Asp Thr Asn Ala Phe Pro Arg Leu Arg Phe Gln Leu Tyr Ile Gly 
                325                 330                 335     


Lys Leu Leu Gln Lys Thr Tyr Asp Lys Ala Leu Gln Gly Glu Thr Tyr 
            340                 345                 350         


Gln Arg Gln Ile Ala Lys Glu Ile Tyr Ala Phe Gly Lys Leu Ser Glu 
        355                 360                 365             


Phe Leu Gly Thr Gln Pro Thr Lys His Pro Leu Leu Lys Asn Met Thr 
    370                 375                 380                 


Val Tyr Glu Gln His Thr Ile Asp Thr Ala Thr Gly Ala Val Ile Asn 
385                 390                 395                 400 


Asn Pro Asn Ala Pro Glu Ile Gly Gln Ile Val Gln Phe Ser Pro Gln 
                405                 410                 415     


Tyr Asn Phe Gly Thr Asn Lys Ile Met Leu Lys Ile Gly Lys Glu Thr 
            420                 425                 430         


Thr Val Asp Ser Lys Ala Leu Glu Tyr Arg Arg Gly Glu Lys Gly Val 
        435                 440                 445             


Val Leu Lys Asp Lys Met Lys Ile Lys Lys Ile Glu Pro Glu Glu Lys 
    450                 455                 460                 


Glu Ala Ile Leu Ser Thr His Glu Leu Pro Asn Leu Phe Leu Tyr His 
465                 470                 475                 480 


Tyr Leu Tyr Lys Gln Gly His Leu Thr Ser Thr Val Glu Ser Phe Ile 
                485                 490                 495     


Glu Lys Tyr Ile Asp Thr Phe Arg Lys Phe Ile Lys Ser Val Gln Thr 
            500                 505                 510         


Lys Gln Phe Leu Pro Leu Glu Lys Ser Ala Phe Lys Arg Arg Ser Ile 
        515                 520                 525             


Ser Tyr Lys Asp Arg Lys Glu Ala Thr Ile Lys Lys Ala Pro Gln Thr 
    530                 535                 540                 


Gly Arg Glu Pro Tyr Asn Asp Lys Asn Phe Glu Glu Leu Lys Asp Arg 
545                 550                 555                 560 


Lys Thr Ala Leu Gln His Arg Leu Asp Asn Ser Asp Phe Lys Gly Leu 
                565                 570                 575     


Tyr Trp Ser Tyr Leu Pro Asp Glu Ile Val Asn Tyr Leu Leu Asn Thr 
            580                 585                 590         


Gln Pro Thr Asp Tyr Lys Thr Val Val Leu Ala Lys Ile Asp Glu Leu 
        595                 600                 605             


Lys Asp Gln Thr Asn Glu Leu Lys Gln Gln Phe Lys Arg Ile Asn Lys 
    610                 615                 620                 


Arg Lys Ala Phe Phe Glu Glu Glu Gln Glu Glu Asn Pro Thr Asn Asp 
625                 630                 635                 640 


His Thr Ala Thr Phe Ser Thr Gly Leu Arg Val Gly Glu Ile Ala Thr 
                645                 650                 655     


Trp Leu Ala Lys Asp Ile Ile Phe Leu Lys Pro Tyr Gln Lys Asp Val 
            660                 665                 670         


Lys Asn Tyr Gly Lys Pro Asn Asn Asp Gln Tyr Asn Arg Leu Gln Thr 
        675                 680                 685             


Leu Leu Ala Leu Tyr Pro Leu Tyr Lys Asp Glu Leu Pro Lys Phe Phe 
    690                 695                 700                 


Glu Glu Leu His Leu Ile Gly Gly Lys Ser Thr Glu Asn His Pro Phe 
705                 710                 715                 720 


Leu Ser Gln Asn Leu Pro Asn Ser Leu Tyr Asp Phe Tyr Gln Asn Tyr 
                725                 730                 735     


Ile Asp Ala Lys Leu Lys Trp Leu Ile Gln Leu His Thr Asp Ile Asp 
            740                 745                 750         


Gly Val Lys Arg Lys Asp Lys Ala Thr Gln Ser Ile Lys Thr Val Lys 
        755                 760                 765             


Glu Gly Leu Asn Pro Thr Gln Ile Glu Asn Leu Tyr Ser His Leu Phe 
    770                 775                 780                 


Gly Lys Ile Ser Gln Val Glu Thr Asn Ile Glu Ser Lys Lys Tyr Asp 
785                 790                 795                 800 


Thr Leu Pro Ile Ala Leu Pro Val Gly Leu Phe Asn Ala Ala Ile Leu 
                805                 810                 815     


Glu Gly Met Gln Arg Lys Gly Ile Ala Leu Ser Glu Lys Asp Asn Thr 
            820                 825                 830         


Leu Phe Ala Leu Lys Asn Leu Leu Gln Asn Asp Thr Gln Glu Phe Tyr 
        835                 840                 845             


His Tyr Pro Arg Arg Tyr Glu Thr Thr Gln Glu Ile Leu Gln Pro Phe 
    850                 855                 860                 


Leu Thr His Ser Gly Ser Ala Cys Lys Asp Leu Ala Glu Arg Glu Lys 
865                 870                 875                 880 


Leu Met Glu Ser Leu Lys Asn Glu Ile Asn Arg Leu Gly Lys Ser Thr 
                885                 890                 895     


Asn Glu Glu Lys Leu Ile Leu Arg Arg Thr Leu Val Asn Phe Arg Ser 
            900                 905                 910         


Arg Val Leu Glu Lys Glu Gln Thr Ile Arg Phe Thr Gln Gln Gln Asp 
        915                 920                 925             


Arg Cys Leu Trp Leu Met Cys Gln Glu Leu Thr Asn Tyr Arg Lys Glu 
    930                 935                 940                 


Lys Thr Gln Glu Gly Ile Gln Leu Asp Phe Thr Asn Thr Ser Leu Gln 
945                 950                 955                 960 


Lys Leu Glu Glu Leu Leu Asp Thr Asn Lys Glu Met Lys Leu Gln Val 
                965                 970                 975     


Tyr Ile Tyr Lys Thr Lys Gln Ala Ile Gly Ile Ile Thr Asp Thr Leu 
            980                 985                 990         


Pro Ile Arg Arg Tyr Gly Asp Leu  Arg Arg Phe Ala Lys  Asn Arg Gln 
        995                 1000                 1005             


Leu Pro  Asn Leu Tyr Asp Tyr  Phe Tyr Asp Glu Asn  Gln His Gln 
    1010                 1015                 1020             


Asn Gly  Asn Leu Pro Thr Phe  Ser Pro Gln Asn Leu  Gln Asp Ala 
    1025                 1030                 1035             


Leu Glu  Phe Leu Glu Lys Asn  Arg Pro Ser Ile Leu  Gln Lys Ala 
    1040                 1045                 1050             


Leu Asp  Leu Glu Glu Val Ile  Phe Ser Asn Tyr Glu  Val Glu Phe 
    1055                 1060                 1065             


Val Ala  Tyr Lys Ala Ala Asn  Ser Thr Lys Thr Asp  Pro Asp His 
    1070                 1075                 1080             


Asn Ile  Phe Ile Glu Tyr Leu  Phe Ser Lys Leu Pro  Glu Thr Thr 
    1085                 1090                 1095             


Leu Thr  Gln Ile Ala Gly Ala  Asn Thr Glu Ala Lys  Lys Ile Phe 
    1100                 1105                 1110             


Lys Leu  Arg Asn His Ile Leu  His Asn Glu Val Pro  Pro Lys Glu 
    1115                 1120                 1125             


Tyr Ile  Gly Asn His Leu Thr  Gln His Leu Gly Lys  Asn Pro Glu 
    1130                 1135                 1140             


Thr Pro  Leu Gln Val Thr Glu  Phe Ile Ile Ala His  Thr Ile Arg 
    1145                 1150                 1155             


Ile Tyr  Glu Gln Leu Ala Ala  Ala Val 
    1160                 1165         


<210>  2026
<211>  1134
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2026

Met Asn Glu Thr Asp Tyr Leu Ala Lys Arg Leu Glu Tyr Asn Tyr Ala 
1               5                   10                  15      


Ser Ile Glu Asp Lys His Tyr Phe Gly Gly Tyr Phe Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asn Asp Leu Ser Lys Ala Phe Lys Glu Lys Phe Gly Met 
        35                  40                  45              


Lys Pro Lys Ser Cys Ile Leu Asp Phe Phe Thr Gln Asp Lys Ala Ile 
    50                  55                  60                  


Ala Glu Tyr Gln Leu Gly Val Glu Phe Leu Gln Lys Asn Leu Pro Val 
65                  70                  75                  80  


Ile Arg Tyr Leu Tyr Leu Pro Thr Ser His Lys Arg Phe Glu Asn Val 
                85                  90                  95      


Pro Lys Asn Gln Leu Ile Ser Glu Gln Arg Asn Tyr Phe Lys Asn Ser 
            100                 105                 110         


Leu Lys Val Leu Lys Asn Leu Ile Arg Asp Tyr Arg Asn Phe Tyr Thr 
        115                 120                 125             


His His Phe His Lys Pro Ile Pro Val Phe Pro Glu Thr Tyr Lys Leu 
    130                 135                 140                 


Leu Asp Asp Leu Phe Leu Ala Val Ala Asn Asp Val Lys Lys His Arg 
145                 150                 155                 160 


Met Lys Thr Asp Ala Ser Lys Gln Leu Leu Lys Lys Gly Leu Ile Glu 
                165                 170                 175     


Glu Leu Ala Gln Leu Glu Lys Leu Lys Leu Glu Asp Leu Lys Lys Leu 
            180                 185                 190         


Lys Arg Glu Gly Lys Lys Val Asn Leu Asn Asp Lys Glu Ala Ile Thr 
        195                 200                 205             


Asn Ala Ile Leu Asn Asp Ser Phe Ser His Leu Leu Pro Lys Glu Asn 
    210                 215                 220                 


Thr Ile Ser Lys Tyr Tyr Ser Ala Val Pro Thr Glu Asp Ile Asp Thr 
225                 230                 235                 240 


Glu Asn Gly Val Thr Ile Ser Glu Ser Gly Ile Ile Phe Leu Leu Gly 
                245                 250                 255     


Leu Phe Leu Thr Lys Lys Gln Ser Glu Asp Leu Arg Ser Arg Val Lys 
            260                 265                 270         


Gly Phe Lys Ala Lys Leu Ile Val Asn Pro Glu Asn Pro Ile Asn Lys 
        275                 280                 285             


Lys Asn Asn Ser Leu Lys Tyr Met Ala Thr His Trp Val Phe Gly Tyr 
    290                 295                 300                 


Leu Gly Phe Lys Gly Leu Lys Asn Arg Phe Thr Thr Thr Phe Thr Lys 
305                 310                 315                 320 


Asp Thr Leu Leu Ala Gln Ile Val Asp Glu Leu Ser Lys Val Pro Asp 
                325                 330                 335     


Glu Leu Tyr Gln Val Leu Pro Glu Glu Leu Lys Asn Glu Phe Leu Glu 
            340                 345                 350         


Asp Met Asn Glu Tyr Leu Lys Glu Glu Asn Ser Glu Ser Leu Asp Lys 
        355                 360                 365             


Ala Thr Val Ile His Pro Val Ile Arg Lys Arg Tyr Glu Asn Lys Phe 
    370                 375                 380                 


Ala Tyr Phe Ala Leu Arg Phe Leu Asp Glu Phe Val Asp Phe Pro Thr 
385                 390                 395                 400 


Leu Arg Phe Gln Leu His Leu Gly Asn Tyr Val His Asp Lys Arg Glu 
                405                 410                 415     


Lys Pro Ile Glu Gly Thr Lys Tyr Val Thr Glu Arg Ile Val Lys Glu 
            420                 425                 430         


Lys Ile Lys Ala Phe Ala Lys Leu Ser Glu Ala Ala Gln Leu Lys Gln 
        435                 440                 445             


Lys Tyr Phe Glu Glu Lys Glu Asn His Gln Ser Ile Gly Leu Gln Leu 
    450                 455                 460                 


Tyr Pro Asn Pro Ser Tyr Asn Phe Val Gly Asn Asn Ile Pro Ile His 
465                 470                 475                 480 


Leu Asn Leu Asn Glu His Phe Phe Pro Lys Glu Val Lys Ile Val Ala 
                485                 490                 495     


Gly Arg Leu Lys Lys Arg Asn Ser Ser Tyr Lys Ser Asp His Pro Glu 
            500                 505                 510         


Glu Tyr Lys Val Arg Thr Asp Asn Lys Ile Lys Pro Asp Ala Ile Leu 
        515                 520                 525             


Gln Asp Leu Gly Lys Pro Glu Lys Leu Ala Pro Val Ala Met Leu Ser 
    530                 535                 540                 


Leu Asn Glu Leu Pro Ala Leu Leu His Leu Val Leu Thr Lys Lys Thr 
545                 550                 555                 560 


Pro Glu Glu Ile Glu Ile Ile Ile Ala Gln Lys Ile Ala Glu Arg Tyr 
                565                 570                 575     


Asn Val Leu Thr Asn Tyr Lys Ala Gly Asp Asp Ile Ser Lys Gly Gln 
            580                 585                 590         


Ile Thr Lys Asn Leu Leu Lys Ala Lys Gln Lys Lys Glu Val Asn Leu 
        595                 600                 605             


Asp Lys Leu Gln Leu Ala Ile Glu Lys Glu Ile Ala Val Thr Asn Asp 
    610                 615                 620                 


Lys Leu Gln Thr Ile Ala Leu His Ile Lys Glu Arg Asn Asp Pro Lys 
625                 630                 635                 640 


Gln Lys Arg Lys Tyr Val Phe Thr Asn Lys Glu Ile Gly Leu Gln Val 
                645                 650                 655     


Thr Trp Leu Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Gly Ser Arg 
            660                 665                 670         


Gln Asn Trp Arg Gly Gln His His Ser Gln Leu Gln Lys Ser Leu Ala 
        675                 680                 685             


Phe Tyr Asp Ile Gln Pro Lys Glu Pro Leu Ser Leu Leu Glu Glu Val 
    690                 695                 700                 


Trp Asp Phe Lys Asn Glu Ala Tyr Leu Trp Asn Asn Gly Ile Arg Arg 
705                 710                 715                 720 


Ser Phe Asp Lys Arg Asp Phe Ile Ser Phe Tyr Thr Ser Tyr Leu Asn 
                725                 730                 735     


Asn Arg Lys Glu Thr Phe Gln Arg Phe Lys Asp Gln Leu Asn Gly Ile 
            740                 745                 750         


Arg Ser Asn Lys Lys Ile Leu Asp Lys Phe Ile Lys Gln Gln His Leu 
        755                 760                 765             


Trp Asn Leu Phe His Lys Arg Leu Tyr Val Ile Asp Thr Ile Glu Glu 
    770                 775                 780                 


Gln Val Glu Lys Leu Leu Val Lys Pro Met Gln Phe Pro Lys Gly Val 
785                 790                 795                 800 


Phe Asp His Lys Pro Thr Tyr Ile Lys Gly Lys Ser Ile Gln Glu Asn 
                805                 810                 815     


Pro Glu Cys Phe Ala Asp Trp Tyr Val Ala Trp Asn Gln His Thr Asp 
            820                 825                 830         


Tyr Gln Lys Phe Tyr Ser Trp Asp Arg Asp Tyr Lys Ser Ala Tyr Leu 
        835                 840                 845             


Ser Gly Glu Gln Glu Lys Thr Glu Lys Arg Phe Ile Arg Val Gln Gly 
    850                 855                 860                 


Ser Lys Ile Asn Lys Val Lys Gln Gln Asp Val Leu Leu Ala Lys Met 
865                 870                 875                 880 


Ala Ser Ile Ile Phe Asn Glu Leu Tyr Leu Pro Glu Asp Ala Glu His 
                885                 890                 895     


Leu Asp Leu Asn Leu Ser Asp Ile Tyr Lys Thr Gln Thr Glu Arg Lys 
            900                 905                 910         


Ala Glu Ile Glu Ala Ala Leu Ile Gln Ser His Lys Thr Thr Gly Asp 
        915                 920                 925             


Asn Ser Ala Asn Ile Ile Lys Ser Thr Ser Ala Trp Thr Leu Thr Val 
    930                 935                 940                 


Pro Tyr Cys Ser Lys Asn Ile Tyr Glu Pro Gln Val Lys Leu Lys Glu 
945                 950                 955                 960 


Leu Gly Lys Phe Lys Lys Phe Ile Ala Ser Gln Lys Val Gln Thr Leu 
                965                 970                 975     


Phe Glu Tyr Lys Pro Gln Lys Ile Trp Asn Lys Thr Glu Leu Glu Glu 
            980                 985                 990         


Val Leu Glu Leu Lys Ala Asn Ser  Tyr Glu Val Ile Arg  Arg Asp Tyr 
        995                 1000                 1005             


Leu Leu  Lys Ser Ile Gln Glu  Phe Glu Lys Tyr Met  Ile Lys Lys 
    1010                 1015                 1020             


Leu Pro  Thr Leu Ile Asp Thr  Asn Glu His Pro Asn  Phe Asn Lys 
    1025                 1030                 1035             


Tyr Leu  Thr Thr Phe Leu Lys  Ser Leu Glu Leu Val  Ser Glu Glu 
    1040                 1045                 1050             


Asp Ala  Lys Trp Leu Ile Ser  Lys Lys Asp Phe Asp  Thr Thr Pro 
    1055                 1060                 1065             


Ile Asp  Glu Leu Lys Lys Gln  Ser Lys Ile Met Glu  Lys Ala Phe 
    1070                 1075                 1080             


Leu Leu  Val Met Ile Arg Asn  Lys Phe Ser His Asn  Gln Leu Pro 
    1085                 1090                 1095             


Arg Lys  Ile Tyr Tyr Asp Glu  Ile Tyr Lys Asn Val  Pro Asn Ala 
    1100                 1105                 1110             


Val Ser  Ile Asn Phe Asn Glu  Leu Phe Leu Glu Tyr  Thr Asn Gln 
    1115                 1120                 1125             


Thr Ile  Leu Glu Phe Lys 
    1130                 


<210>  2027
<211>  1159
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2027

Met Ser Ser Lys Asn Glu Ser Tyr Asn Lys Gln Lys Thr Phe Asn His 
1               5                   10                  15      


Tyr Lys Gln Glu Asp Lys Tyr Phe Phe Gly Gly Phe Leu Asn Asn Ala 
            20                  25                  30          


Glu Glu Asn Ile Ile Thr Ser Phe Lys Glu Ile Ala Lys Arg Leu Asn 
        35                  40                  45              


Ser Lys Glu Lys Asn Lys Pro Ile Glu Ile Leu Gln Glu Ile Leu Ser 
    50                  55                  60                  


Glu Thr Ile Ile Asp Thr Glu Trp Asp Arg Asn Ile Lys Val Ile Ala 
65                  70                  75                  80  


Glu Tyr Phe Pro Phe Val Lys Leu Leu Glu Thr Ile Thr Gln Lys Gln 
                85                  90                  95      


Tyr Glu Glu Asn Gln Asn Lys Leu Phe Phe Lys Glu Arg Asn Pro Arg 
            100                 105                 110         


Gln Asn Phe Lys Asn Leu Phe Leu Tyr Asn Cys Ile Ile Leu Phe Asn 
        115                 120                 125             


Cys Pro Leu Gln Leu Arg Asp Phe Tyr Thr His Phe Tyr His Arg Asn 
    130                 135                 140                 


Phe Ile Thr Ile Ser Phe Pro Asp Phe Arg Arg Thr Thr Thr Asp Asn 
145                 150                 155                 160 


Ile Ser Ile Tyr Asp Tyr Val Lys Asn Glu Ala Ile Gln His Ser Ala 
                165                 170                 175     


Gln Ser Asp Gly Val Asn Phe Ile Ala His Ser Ile Phe Glu Leu Leu 
            180                 185                 190         


Asp Glu Leu Lys Leu Glu Thr Val Ser Gln Val Asn Asn Gln Arg Ile 
        195                 200                 205             


Lys Pro Asn Glu Lys His Ser Phe Leu Lys Lys Asn Tyr Gln Asn Asp 
    210                 215                 220                 


Phe Thr Asp Leu Thr Glu Glu Glu Ile Ser Lys Lys Phe Lys Lys Val 
225                 230                 235                 240 


Phe Asn Gln Phe Trp Thr Phe Asn Asp Tyr Lys Gly Arg Met Val Leu 
                245                 250                 255     


Lys Asp Phe His Lys Ser His Phe Val Glu Lys Val Glu Glu Gly Ser 
            260                 265                 270         


Met Glu Gln Lys Pro Lys Lys Asp Phe Phe His Gln Lys Ile Ser Arg 
        275                 280                 285             


Ser Gly Phe Leu Phe Leu Leu Ser Leu Phe Val Asp Arg Lys Asn Ala 
    290                 295                 300                 


Glu Phe Ile Leu Asp Asn Ser Thr Asn Phe Lys Ala Ser Phe Asp Leu 
305                 310                 315                 320 


Gln Lys Leu Ala Thr Arg Trp Val Tyr Thr Tyr Asn Cys Tyr Arg Gly 
                325                 330                 335     


Leu Lys Asn Thr Ile Asn Thr Thr Phe Pro Lys Glu Thr Leu Leu Ser 
            340                 345                 350         


Lys Met Val Asp Tyr Leu Ser Lys Val Pro Asp Glu Val Tyr Gln Leu 
        355                 360                 365             


Leu Ser Ile Glu Gln Gln Glu Met Phe Leu Glu Asp Met Asn Glu Tyr 
    370                 375                 380                 


Met Arg Asp Asn Glu Glu Asn Asn Asp Ser Ser Glu Ala Ser Lys Val 
385                 390                 395                 400 


Val His Pro Val Ile Arg Lys Arg Tyr Ser Asn Glu Phe Asn Tyr Leu 
                405                 410                 415     


Ala Leu Ser Phe Ile Asp Gln Tyr Ile Gln Leu Pro Asn Leu Arg Phe 
            420                 425                 430         


Ala Ile Asn Leu Gly Thr Tyr Val His Asn Lys Glu Glu Lys Ile Val 
        435                 440                 445             


Gly Lys Gly Lys Thr Ser Ser Thr Ser Asn Arg Val Ile Lys Glu Asp 
    450                 455                 460                 


Ile Arg Ile Tyr Ala Arg Leu His Glu Ala Ile Asp Phe Lys Asn Ile 
465                 470                 475                 480 


Phe Phe Leu Lys Glu Asn Phe Ser Glu Asp Asn Lys Gly Cys His Trp 
                485                 490                 495     


Glu Glu Phe Pro Asn Pro His Tyr Ala Ile Lys Asp Asn Asn Ile Gly 
            500                 505                 510         


Ile Tyr Phe Ile Asn Lys Asp Val Ile Gln Asn Asn Leu Glu Glu Arg 
        515                 520                 525             


Ser Asn Gly Glu Lys Lys Lys Ala Ser Ile Ile Glu Ile Leu Thr Glu 
    530                 535                 540                 


Thr Glu Ser Asp Thr Ile Lys Tyr Gly Lys Pro His Ala Leu Leu Ser 
545                 550                 555                 560 


Cys Tyr Glu Leu Ile Pro Leu Ile Phe Asp Tyr Phe Gln Lys Val Lys 
                565                 570                 575     


Asn Ser Arg Glu Lys Lys Leu Asn Glu Lys Glu Leu Glu Ala Ile Pro 
            580                 585                 590         


Ile Gln Ile Glu Asn Lys Ile Leu Ser Ala Ile Asn Arg Phe Thr Lys 
        595                 600                 605             


Ser Phe Glu Asn Tyr Ser Glu Gly Lys Asn Ile Leu Lys Ser Tyr Pro 
    610                 615                 620                 


Lys Lys Leu Ser Lys Thr Ser Asn Glu Thr Ser Phe Leu Glu Val Gln 
625                 630                 635                 640 


Asp Glu Asn Gly Asn Pro Val Lys Lys Ile Leu Gln Asp Ile Asp Lys 
                645                 650                 655     


Glu Ile Gln Lys Ser Gln Asp Lys Leu Asp Ile Leu Lys Lys Asn Glu 
            660                 665                 670         


Asn Glu Phe Gln Asn Asp Glu Arg Lys Thr Thr Phe Ser Lys Lys Glu 
        675                 680                 685             


Ile Gly Glu Glu Ala Thr Trp Leu Ala Asn Asp Ile Leu Arg Phe Met 
    690                 695                 700                 


Pro Ser Ser Phe Lys Lys Asp Trp Lys Gly Tyr Glu His Ser His Leu 
705                 710                 715                 720 


Gln Tyr Leu Leu Ala Phe Tyr Asp Val Arg Lys Thr Glu Ile Phe Gln 
                725                 730                 735     


Leu Leu Asn Gln Lys Trp Pro Leu Tyr Glu Asp Asn Phe Met Gly Lys 
            740                 745                 750         


Ser Leu Lys Thr Phe Leu Asp Asn Arg Lys Thr Phe Glu Ser Phe Tyr 
        755                 760                 765             


Lys Gly Tyr Leu Asp Lys Arg Lys Glu Ile Phe Glu Asn Leu Lys Asn 
    770                 775                 780                 


Asn Leu Ser Leu Asn Asn Asp Asn Leu Phe Arg Val Phe Asp Lys Arg 
785                 790                 795                 800 


Lys Tyr Ile Thr Gln Ser Leu Glu Cys Tyr Lys Asn Ala Ile Leu Glu 
                805                 810                 815     


Gln Pro Val Ser Phe Ser Arg Gly Ile Phe Glu Asp Lys Lys Val Ser 
            820                 825                 830         


Val Lys Asn Glu Trp Ser Ile Ile Pro Lys Asp Pro Thr Thr Gln Tyr 
        835                 840                 845             


Gln Ser Phe Tyr Asn Leu Ile Asn Val Tyr Thr Asn Glu Ala Ile Asp 
    850                 855                 860                 


Lys Glu Glu Lys Lys Glu Lys Tyr Lys Asn Leu Arg Ala Ile Asn Lys 
865                 870                 875                 880 


Val Lys Ile Gln Asp Tyr Tyr Leu Lys Leu Met Val Asp Thr Leu Tyr 
                885                 890                 895     


Gln Asp Leu Phe Asn Gln Pro Leu Asp Lys Ser Leu Ser Asp Phe Tyr 
            900                 905                 910         


Val Ser Lys Ala Glu Arg Glu Lys Ile Lys Ala Asn Ala Lys Ala Tyr 
        915                 920                 925             


Gln Lys Cys Asn Asp Ser Ser Leu Trp Asn Lys Val Ile Asp Leu Ser 
    930                 935                 940                 


Leu Gln Asn Asn Arg Ile Thr Ala Asn Pro Lys Leu Lys Asp Ile Gly 
945                 950                 955                 960 


Lys Tyr Lys Arg Ala Val Gln Asp Glu Lys Ile Ala Thr Leu Leu Thr 
                965                 970                 975     


Tyr Asp Asn Arg Thr Trp Thr Tyr Ala Leu Gln Lys Pro Lys Lys Lys 
            980                 985                 990         


Asn Lys Asn Asp Tyr Lys Glu Leu  His Tyr Thr Ala Leu  Asn Met Glu 
        995                 1000                 1005             


Leu Gln  Glu Tyr Glu Lys Val  Arg Ser Lys Lys Leu  Leu Lys Gln 
    1010                 1015                 1020             


Val Gln  Gln Leu Glu Lys Gln  Ile Leu Glu Glu Tyr  Thr Asp Phe 
    1025                 1030                 1035             


Leu Ser  Thr Gln Ile His Pro  Ala Asp Phe Glu Arg  Glu Gly Asn 
    1040                 1045                 1050             


Pro Asn  Phe Lys Lys Tyr Leu  Ala His Ser Ile Leu  Glu Asn Glu 
    1055                 1060                 1065             


Asp Asp  Leu Asp Lys Leu Pro  Glu Lys Ala Glu Ala  Met Arg Glu 
    1070                 1075                 1080             


Leu Asp  Glu Thr Ile Thr Asn  Pro Ile Ile Lys Lys  Ala Ile Val 
    1085                 1090                 1095             


Leu Ile  Ile Ile Arg Asn Lys  Met Ala His Asn Gln  Tyr Pro Pro 
    1100                 1105                 1110             


Lys Phe  Ile Tyr Asp Leu Ala  Asn Arg Phe Val Pro  Lys Lys Glu 
    1115                 1120                 1125             


Glu Glu  Tyr Phe Ala Thr Tyr  Phe Asn Arg Val Phe  Glu Thr Ile 
    1130                 1135                 1140             


Thr Lys  Glu Leu Trp Glu Asn  Lys Glu Lys Lys Asp  Lys Thr Gln 
    1145                 1150                 1155             


Val 
    


<210>  2028
<211>  1184
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2028

Met Glu Thr Lys Lys Leu Asn Ile Lys Thr Ile Gln Asp Asn Pro Glu 
1               5                   10                  15      


Tyr Phe Gly Ser Tyr Leu Asn Met Ala Arg His Asn Val Phe Leu Leu 
            20                  25                  30          


Ile Asn His Leu His Lys Thr Phe Lys Tyr Leu Pro Phe Gln Glu Leu 
        35                  40                  45              


Lys Asn Asp Gln His Ile Ala Thr Ile Glu Asn Asn Ile Leu Leu Asn 
    50                  55                  60                  


Ile Phe Asp Thr Ser Lys Lys Glu Phe Glu Asp Glu Arg Gln Lys Val 
65                  70                  75                  80  


Tyr Asn Tyr Leu Ile Lys Arg His His Leu Pro Ile Ile Lys Tyr Ile 
                85                  90                  95      


Gly Lys Asn Glu Glu Asn Asp Leu Ile Asp Phe Glu Glu Ile His Lys 
            100                 105                 110         


Phe Leu Val Ile Ala Phe Lys Glu Leu Asn Lys Leu Arg Asn Ser Tyr 
        115                 120                 125             


Thr His Tyr Leu Ala Ile Asp Asn Asn Lys Asn Val Leu Lys Arg Lys 
    130                 135                 140                 


Leu Asp Ile Asn His Glu Leu Lys Lys Asn Ile Glu Lys Leu Phe Lys 
145                 150                 155                 160 


Val Ala Pro Tyr Ile Ser Tyr Leu Arg Asn Phe Glu Thr Gln Lys Gln 
                165                 170                 175     


Glu Asp Tyr Ser His Leu Leu Ser Asn Tyr Gln Leu Phe Lys Asn Glu 
            180                 185                 190         


Asp Ile Leu Thr Glu His Gly Phe Tyr Phe Phe Ile Asn Leu Phe Ile 
        195                 200                 205             


Glu Arg Lys Tyr Ala Ile Lys Leu Leu Lys Lys Ile Arg Gly Phe Lys 
    210                 215                 220                 


Asn Glu Thr Thr Pro Ala Phe Lys Ser Thr Leu Gln Thr Phe Thr Ser 
225                 230                 235                 240 


Tyr Cys Leu Lys Ile Pro Asp Thr Arg Leu Asp Asn Gly Phe Pro Lys 
                245                 250                 255     


Gln Thr Ile Leu Met Glu Ile Leu Ser Glu Leu Asn Lys Cys Pro Lys 
            260                 265                 270         


Glu Leu Tyr Asn His Leu Thr Gln Asn Asp Lys Glu Lys Phe Glu Pro 
        275                 280                 285             


Lys Ile Lys Glu Glu Gln Ile Ile Asn Ser Asp Asn Tyr Leu Asp Ile 
    290                 295                 300                 


Asp Asn Glu Ser Ile Asp Ser Leu Val Lys Asp Leu Val Ser Leu Lys 
305                 310                 315                 320 


Arg Tyr Glu Asp Arg Phe Pro Asn Phe Ala Leu Arg Phe Ile Asp Glu 
                325                 330                 335     


Ala Asn Phe Phe Asp Arg Ile Arg Phe Gln Ile Thr Ile Gly Lys Leu 
            340                 345                 350         


Val Ile Lys Arg Tyr Asn Lys Thr Ile Ile Gly Asn Gln Gln Asp Arg 
        355                 360                 365             


Arg Val Ile Lys Ile Ile Asn Ala Tyr Gly Lys Leu Asn Asp Phe Ile 
    370                 375                 380                 


Gly Lys Glu Thr Glu Ile Leu Asn Gln Leu Lys Lys Asp Leu Asp Asp 
385                 390                 395                 400 


Asp Thr Ile Val Phe Glu Gln Phe Ala Pro His Tyr Asn Thr Asn Asn 
                405                 410                 415     


Asn Lys Ile Ala Phe Lys Ile Phe Asp Thr Asn Ser Ile Lys Ile Gln 
            420                 425                 430         


Tyr Pro Lys Val Phe Glu Asn Lys Lys Glu Ile Glu Ala Leu His Asn 
        435                 440                 445             


Asn Pro Ser Gly Phe Ile Ser Ile His Asp Leu His Lys Ile Val Leu 
    450                 455                 460                 


Ala Ser Leu Leu Thr Gln Asn Thr Lys His Ser Lys Asn Val Ala Thr 
465                 470                 475                 480 


Glu Thr Ile Ile Ile Asp Phe Val Asn Asn Thr Asn Ala Thr Ile Leu 
                485                 490                 495     


Asp Ile Asp Arg Leu Gln Ser Ile Lys Asn Asp Val Gln Phe Glu Pro 
            500                 505                 510         


Glu Asn Phe Thr Lys Arg Val Phe Asp Glu Lys Lys Met Arg Val Arg 
        515                 520                 525             


Gly Ser Arg Lys Pro Gln Phe Val Thr Lys Gln Thr Glu Ala Lys Leu 
    530                 535                 540                 


Leu Leu Lys Tyr Lys Leu His Ser Gln Glu Leu Tyr Ser Leu Ser Arg 
545                 550                 555                 560 


Asp Glu Phe Lys Lys Ile Ala Lys Asn Asn Ala Ile Asp Leu Glu Val 
                565                 570                 575     


Phe Asn Gln Ile Lys Tyr Lys Tyr Tyr Leu Glu Ser Arg Lys Lys Thr 
            580                 585                 590         


Leu Gln Ser Gly Leu Pro Lys Asn Ile Leu Val Asn Gln Leu Pro Gln 
        595                 600                 605             


Arg Val Leu Asn His Leu Met Asn Ile Ser Glu Thr Ser Thr Gln Thr 
    610                 615                 620                 


Arg Ile Tyr Leu Lys Ile Lys Ala Ile Lys Gln Glu Asn Val Asn Leu 
625                 630                 635                 640 


Leu Lys Thr Ala Lys Lys Glu Leu Lys Asp Gly Gln Ile Ile Lys Leu 
                645                 650                 655     


Gly Glu Tyr Ala Met Tyr Leu Cys Arg Asp Ile Leu Asn Met Ile Ile 
            660                 665                 670         


Asp Lys Asp Leu Lys Gln Lys Ile Thr Gln Pro Tyr Ile Lys Lys Ile 
        675                 680                 685             


Gln Asn Arg Leu Ser Tyr Phe Ser Ile Ser Lys Val Glu Leu Val Ala 
    690                 695                 700                 


Ile Leu Lys Glu Leu Gln Leu Phe Asp Lys Asn Lys Gly His Val Phe 
705                 710                 715                 720 


Leu Glu Gln Ser His Ile Ser Asn Ser Lys Gly Ile Lys Asp Phe Tyr 
                725                 730                 735     


Ile Lys Tyr Leu Glu Glu Lys Asn Ser Trp Leu Asn Phe Phe Leu Asn 
            740                 745                 750         


Gln Leu Lys Asp Glu His Tyr Asn Lys Gln Arg Ile Pro Tyr Thr Tyr 
        755                 760                 765             


Gln Gly Ile Ile Asn Lys Tyr Glu Asp Phe Asn Phe Thr Lys Trp Leu 
    770                 775                 780                 


Ser Asn Lys Thr Lys Met Pro Val Asn Ile Pro Asn Ser Leu Leu Asp 
785                 790                 795                 800 


Asn Phe Val Asn Thr Ala Leu Lys Ile Lys Leu Lys Lys Gln Asn Ile 
                805                 810                 815     


Ala Tyr Asn Asn His Asp Thr Leu Ser Val Leu Ile Ala Lys Ile Met 
            820                 825                 830         


Asn Lys Asp Thr Gln Pro Phe Tyr Asn Tyr Glu Arg Val Tyr Lys Asp 
        835                 840                 845             


Lys Ser Lys Asn Ser Ile His Ile Lys Gln Ile Asn Ser Leu Cys Asn 
    850                 855                 860                 


Lys Thr Ile Lys Ile Glu Tyr Asn Lys Phe Val Glu Ala Asn Glu Lys 
865                 870                 875                 880 


Arg Ile Arg Phe Tyr Gln Thr Lys Asp Arg Val Leu Lys Leu Met Cys 
                885                 890                 895     


Asn Tyr Leu Met Lys Glu Asp Lys Thr Val Gly Leu Glu Asn Glu Ile 
            900                 905                 910         


Leu Leu Lys Asn Ile Tyr Pro Asn Ser Thr Thr Thr Ile Leu Glu Asn 
        915                 920                 925             


Pro Ala Phe Phe Lys Gln Lys Leu Arg Lys Asn Asp Met Asp Asp Thr 
    930                 935                 940                 


Gln Met Ser Lys Ser Asn Glu Asn Leu Tyr Phe Thr Ile Ile Ala Gln 
945                 950                 955                 960 


Asp Asn Leu Lys Gln Ile Glu Glu Ile Gln Lys Trp Asn Thr Leu Thr 
                965                 970                 975     


Pro Asn Glu Lys Leu Lys Trp Thr Ser Leu Lys Thr Lys Glu Glu Gln 
            980                 985                 990         


Gln Ser Phe Leu Gln Asn Cys Asn  Ala Glu Glu Ile Lys  Ile Tyr His 
        995                 1000                 1005             


Gly Gln  Lys Gly Tyr Gln Trp  Lys Phe Lys Asp Tyr  Gly Arg Phe 
    1010                 1015                 1020             


Lys Arg  Phe Val Lys Asp Arg  Arg Leu Asn Glu Leu  Ser Lys Tyr 
    1025                 1030                 1035             


Phe Glu  Met Asn Glu Ile Pro  Phe Asp Ile Leu Glu  Tyr Gln Ile 
    1040                 1045                 1050             


Met Glu  Phe Asp Lys Ile Arg  Glu Lys Ile Phe Glu  His Ile Phe 
    1055                 1060                 1065             


Thr Leu  Glu Lys Ala Ile Tyr  Glu Lys Asp Pro Gln  Gly Leu Ile 
    1070                 1075                 1080             


Lys Leu  Glu Phe Lys His Arg  Pro Lys Glu Phe Asn  Glu Val Lys 
    1085                 1090                 1095             


Phe Asp  Val Tyr Leu Asp Trp  Leu Ser Gln Asn Asn  Leu Cys Phe 
    1100                 1105                 1110             


Asn Lys  Tyr Ile Ile Lys Trp  Gly Arg Asn Lys Phe  Ser His Thr 
    1115                 1120                 1125             


Glu Phe  Pro Tyr Phe Asn Thr  Ile Pro Lys Ile Thr  Lys Lys Gln 
    1130                 1135                 1140             


Ile Glu  Asp Phe Asp Tyr Phe  Lys Asn Val Tyr Gly  Gly Lys Glu 
    1145                 1150                 1155             


Gln Leu  Asn Ile Ser Ile Ala  Gln Lys Ile Ile Glu  Leu Phe Glu 
    1160                 1165                 1170             


Lys Glu  Ile Thr Gln Ile Ile  Glu Lys Ile Lys 
    1175                 1180                 


<210>  2029
<211>  1184
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2029

Met Glu Thr Lys Lys Leu Asn Ile Lys Thr Ile Gln Asp Asn Pro Glu 
1               5                   10                  15      


Tyr Phe Gly Ser Tyr Leu Asn Met Ala Arg His Asn Val Phe Leu Leu 
            20                  25                  30          


Ile Asn His Leu His Lys Thr Phe Lys Tyr Leu Pro Phe Gln Glu Leu 
        35                  40                  45              


Lys Asn Asp Gln His Ile Ala Thr Ile Glu Asn Asn Ile Leu Leu Asn 
    50                  55                  60                  


Ile Phe Asp Thr Ser Lys Lys Glu Phe Glu Asp Glu Arg Gln Lys Val 
65                  70                  75                  80  


Tyr Asn Tyr Leu Ile Lys Arg His His Leu Pro Ile Ile Lys Tyr Ile 
                85                  90                  95      


Gly Lys Asn Glu Glu Asn Asp Leu Ile Asp Phe Glu Glu Ile His Lys 
            100                 105                 110         


Phe Leu Val Ile Ala Phe Lys Glu Leu Asn Lys Leu Arg Asn Ser Tyr 
        115                 120                 125             


Thr His Tyr Leu Ala Ile Asp Asn Asn Lys Asn Val Leu Lys Arg Lys 
    130                 135                 140                 


Leu Asp Ile Asn His Glu Leu Lys Lys Asn Ile Glu Lys Leu Phe Lys 
145                 150                 155                 160 


Val Ala Pro Tyr Ile Ser Tyr Leu Arg Asn Phe Glu Thr Gln Lys Gln 
                165                 170                 175     


Glu Asp Tyr Ser His Leu Leu Ser Asn Tyr Gln Leu Phe Lys Asn Glu 
            180                 185                 190         


Asp Ile Leu Thr Glu His Gly Phe Tyr Phe Phe Ile Asn Leu Phe Ile 
        195                 200                 205             


Glu Arg Lys Tyr Ala Ile Lys Leu Leu Lys Lys Ile Arg Gly Phe Lys 
    210                 215                 220                 


Asn Glu Thr Thr Pro Ala Phe Lys Ser Thr Leu Gln Thr Phe Thr Ser 
225                 230                 235                 240 


Tyr Cys Leu Lys Ile Pro Asp Thr Arg Leu Asp Asn Gly Phe Pro Lys 
                245                 250                 255     


Gln Thr Ile Leu Met Glu Ile Leu Ser Glu Leu Asn Lys Cys Pro Lys 
            260                 265                 270         


Glu Leu Tyr Asn His Leu Thr Gln Asn Asp Lys Glu Lys Phe Glu Pro 
        275                 280                 285             


Lys Ile Lys Glu Glu Gln Ile Ile Asn Ser Asp Asn Tyr Leu Asp Ile 
    290                 295                 300                 


Asp Asn Glu Ser Ile Asp Ser Leu Val Lys Asp Leu Val Ser Leu Lys 
305                 310                 315                 320 


Arg Tyr Glu Asp Arg Phe Pro Asn Phe Ala Leu Arg Phe Ile Asp Glu 
                325                 330                 335     


Ala Asn Phe Phe Asp Arg Ile Arg Phe Gln Ile Thr Ile Gly Lys Leu 
            340                 345                 350         


Val Ile Lys Arg Tyr Asn Lys Thr Ile Ile Gly Asn Gln Gln Asp Arg 
        355                 360                 365             


Arg Val Ile Lys Ile Ile Asn Ala Tyr Gly Lys Leu Asn Asp Phe Ile 
    370                 375                 380                 


Gly Lys Glu Thr Glu Ile Leu Asn Gln Leu Lys Lys Asp Leu Asp Asp 
385                 390                 395                 400 


Asp Thr Ile Val Phe Glu Gln Phe Ala Pro His Tyr Asn Thr Asn Asn 
                405                 410                 415     


Asn Lys Ile Ala Phe Lys Ile Phe Asp Thr Asn Ser Ile Lys Ile Gln 
            420                 425                 430         


Tyr Pro Lys Val Phe Glu Asn Lys Lys Glu Ile Glu Ala Leu His Asn 
        435                 440                 445             


Asn Pro Ser Gly Phe Ile Ser Ile His Asp Leu His Lys Ile Val Leu 
    450                 455                 460                 


Ala Ser Leu Leu Thr Gln Asn Thr Lys His Ser Lys Asn Val Ala Thr 
465                 470                 475                 480 


Glu Thr Ile Ile Ile Asp Phe Val Asn Asn Thr Asn Ala Thr Ile Leu 
                485                 490                 495     


Asp Ile Asp Arg Leu Gln Ser Ile Lys Asn Asp Val Gln Phe Glu Pro 
            500                 505                 510         


Glu Asn Phe Thr Lys Arg Val Phe Asp Glu Lys Lys Met Arg Val Arg 
        515                 520                 525             


Gly Ser Arg Lys Pro Gln Phe Val Thr Lys Gln Thr Glu Ala Lys Leu 
    530                 535                 540                 


Leu Leu Lys Tyr Lys Leu His Ser Gln Glu Leu Tyr Ser Leu Ser Arg 
545                 550                 555                 560 


Asp Glu Phe Lys Lys Ile Ala Lys Asn Asn Ala Ile Asp Leu Glu Val 
                565                 570                 575     


Phe Asn Gln Ile Lys Tyr Lys Tyr Tyr Leu Glu Ser Arg Lys Lys Thr 
            580                 585                 590         


Leu Gln Ser Gly Leu Pro Lys Asn Ile Leu Val Asn Gln Leu Pro Gln 
        595                 600                 605             


Arg Val Leu Asn His Leu Met Asn Ile Ser Glu Thr Ser Thr Gln Thr 
    610                 615                 620                 


Arg Ile Tyr Leu Lys Ile Lys Ala Ile Lys Gln Glu Asn Val Asn Leu 
625                 630                 635                 640 


Leu Lys Thr Ala Lys Lys Glu Leu Lys Asp Gly Gln Ile Ile Lys Leu 
                645                 650                 655     


Gly Glu Tyr Ala Met Tyr Leu Cys Arg Asp Ile Leu Asn Met Ile Ile 
            660                 665                 670         


Asp Lys Asp Leu Lys Gln Lys Ile Thr Gln Pro Tyr Ile Lys Lys Ile 
        675                 680                 685             


Gln Asn Arg Leu Ser Tyr Phe Ser Ile Ser Lys Val Glu Leu Val Ala 
    690                 695                 700                 


Ile Leu Lys Glu Leu Gln Leu Phe Asp Lys Asn Lys Gly His Val Phe 
705                 710                 715                 720 


Leu Glu Gln Ser His Ile Ser Asn Ser Lys Gly Ile Lys Asp Phe Tyr 
                725                 730                 735     


Ile Lys Tyr Leu Glu Glu Lys Asn Ser Trp Leu Asn Phe Phe Leu Asn 
            740                 745                 750         


Gln Leu Lys Asp Glu His Tyr Asn Lys Gln Arg Ile Pro Tyr Thr Tyr 
        755                 760                 765             


Gln Gly Ile Ile Asn Lys Tyr Glu Asp Phe Asn Phe Thr Lys Trp Leu 
    770                 775                 780                 


Ser Asn Lys Thr Lys Met Pro Val Asn Ile Pro Asn Ser Leu Leu Asp 
785                 790                 795                 800 


Asn Phe Val Asn Thr Ala Leu Lys Ile Lys Leu Lys Lys Gln Asn Ile 
                805                 810                 815     


Ala Tyr Asn Asn His Asp Thr Leu Ser Val Leu Ile Ala Lys Ile Met 
            820                 825                 830         


Asn Lys Asp Thr Gln Pro Phe Tyr Asn Tyr Glu Arg Val Tyr Lys Asp 
        835                 840                 845             


Lys Ser Lys Asn Ser Ile His Ile Lys Gln Ile Asn Ser Leu Cys Asn 
    850                 855                 860                 


Lys Thr Ile Lys Ile Glu Tyr Asn Lys Phe Val Glu Ala Asn Glu Lys 
865                 870                 875                 880 


Arg Ile Arg Phe Tyr Gln Thr Lys Asp Arg Val Leu Lys Leu Met Cys 
                885                 890                 895     


Asn Tyr Leu Met Lys Glu Asp Lys Thr Val Gly Leu Glu Asn Glu Ile 
            900                 905                 910         


Leu Leu Lys Asn Ile Tyr Pro Asn Ser Thr Thr Thr Ile Leu Glu Asn 
        915                 920                 925             


Pro Ala Phe Phe Lys Gln Lys Leu Arg Lys Asn Asp Met Asp Asp Thr 
    930                 935                 940                 


Gln Met Ser Lys Ser Asn Glu Asn Leu Tyr Phe Thr Ile Ile Ala Gln 
945                 950                 955                 960 


Asp Asn Leu Lys Gln Ile Glu Glu Ile Gln Lys Trp Asn Thr Leu Thr 
                965                 970                 975     


Pro Asn Glu Lys Leu Lys Trp Thr Ser Leu Lys Thr Lys Glu Glu Gln 
            980                 985                 990         


Gln Ser Phe Leu Gln Asn Cys Asn  Ala Glu Glu Ile Lys  Ile Tyr His 
        995                 1000                 1005             


Gly Gln  Lys Gly Tyr Gln Trp  Lys Phe Lys Asp Tyr  Gly Arg Phe 
    1010                 1015                 1020             


Lys Arg  Phe Val Lys Asp Arg  Arg Leu Asn Glu Leu  Ser Lys Tyr 
    1025                 1030                 1035             


Phe Glu  Met Asn Glu Ile Pro  Phe Asp Ile Leu Glu  Tyr Gln Ile 
    1040                 1045                 1050             


Met Glu  Phe Asp Lys Ile Arg  Glu Lys Ile Phe Glu  His Ile Phe 
    1055                 1060                 1065             


Thr Leu  Glu Lys Ala Ile Tyr  Glu Lys Asp Pro Gln  Gly Leu Ile 
    1070                 1075                 1080             


Lys Leu  Glu Phe Lys His Arg  Pro Lys Glu Phe Asn  Glu Val Lys 
    1085                 1090                 1095             


Phe Asp  Val Tyr Leu Asp Trp  Leu Ser Gln Asn Asn  Leu Cys Phe 
    1100                 1105                 1110             


Asn Lys  Tyr Ile Ile Lys Trp  Gly Arg Asn Lys Phe  Ser His Thr 
    1115                 1120                 1125             


Glu Phe  Pro Tyr Phe Asn Thr  Ile Pro Lys Ile Thr  Lys Lys Gln 
    1130                 1135                 1140             


Ile Glu  Asp Phe Asp Tyr Phe  Lys Asn Val Tyr Gly  Gly Lys Glu 
    1145                 1150                 1155             


Gln Leu  Asn Ile Ser Ile Ala  Gln Lys Ile Ile Glu  Leu Phe Glu 
    1160                 1165                 1170             


Lys Glu  Ile Thr Gln Ile Ile  Glu Lys Ile Lys 
    1175                 1180                 


<210>  2030
<211>  1000
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2030

Met Glu Glu Ala Asn Arg Tyr Ile Tyr Gly Ala Tyr Phe Asn Met Ala 
1               5                   10                  15      


Arg Asp Asn Phe Leu Asn Thr Ile Lys Leu Leu Ala Asp Lys Met Lys 
            20                  25                  30          


Leu Gly Ala Thr Ser Gly Phe Gly Lys Asp Gly Asn Glu Val Asn Asp 
        35                  40                  45              


Ile Asn Glu Leu Phe Gly Asp Lys Asn Thr Tyr Ala Asn Ile Glu Asn 
    50                  55                  60                  


Val Val Glu Phe Tyr Phe Pro Trp Ile Lys Ala Leu Glu Gly Arg Phe 
65                  70                  75                  80  


Ser Leu Asp Lys Gly Asp Arg Asn Leu Asn Asp Met Lys Met Phe Tyr 
                85                  90                  95      


Lys Ser Val Leu Thr Ala Phe Phe Thr Ala Val Asp Ser Leu Arg Asn 
            100                 105                 110         


Lys Tyr Thr His Tyr Ser His Lys Asp Leu Asn Ile Arg Glu Ile Lys 
        115                 120                 125             


Ile Glu Cys Thr Leu Gly Gly Lys Asp Tyr Cys Ile Gly Leu Leu Asn 
    130                 135                 140                 


Ala Leu Asp Cys Ile Tyr Asp Ser Ala Val Asn Leu Leu Lys Leu Arg 
145                 150                 155                 160 


Phe Met Ala Asp Glu Asp Glu Val Ala His Leu Arg Arg Cys Lys Ala 
                165                 170                 175     


Val Asn Lys Lys Val Val Val Arg Thr Glu Lys Asp Gly Phe Tyr Tyr 
            180                 185                 190         


Arg Leu Ser Asp Asn Gly Glu Val Thr Glu Lys Gly Val Ile Phe Ile 
        195                 200                 205             


Ala Ser Met Phe Leu Asn Arg Lys Tyr Gly Phe Leu Phe Leu Lys Gln 
    210                 215                 220                 


Leu Glu Gly Phe Lys Arg Ser Asp Glu Lys Arg Tyr Arg Leu Thr Leu 
225                 230                 235                 240 


Glu Ala Phe Leu Ala Phe Ser Asn Ile Lys Pro Val Asp Arg Leu Lys 
                245                 250                 255     


Ser Asp Lys Leu Asp Arg Ala Ser Leu Gly Leu Asp Met Leu Asn Glu 
            260                 265                 270         


Leu Thr Lys Ile Pro Lys Glu Leu Ser Glu Thr Leu Ser Val Asp Cys 
        275                 280                 285             


Leu Tyr Lys Tyr Leu Ala Ser Asp Gly Glu Asp Asp Leu Arg Ser Arg 
    290                 295                 300                 


Ile Arg Tyr Gln Asp Arg Phe Val Pro Leu Ala Leu Glu Phe Ile Ser 
305                 310                 315                 320 


Gln Ser Asp Glu Phe Lys Asp Phe Arg Phe Tyr Thr Tyr Val Gly Asn 
                325                 330                 335     


Tyr Val Tyr Lys Gly Tyr Ile Lys Arg Leu Ile Asp Gly Thr Asp Lys 
            340                 345                 350         


Glu Arg Tyr Leu Ser Asp Arg Leu Cys Gly Phe Tyr Lys Ser Val Asn 
        355                 360                 365             


Asp Ala Ser Ser Asp Ala Ile Ala Gln Lys Tyr Gly Val Glu Ile Lys 
    370                 375                 380                 


Asp Ser Asn Glu Pro Asp Tyr Met Leu Pro Asp Ser Phe Arg Pro His 
385                 390                 395                 400 


Val Leu Arg Ala Thr Pro His Phe Val Ile Asn Asn Asn Asn Ile Gly 
                405                 410                 415     


Ile Lys Ile Cys Gly Asn Asp Cys Leu Pro Val Val Asn Gly Lys Gly 
            420                 425                 430         


Val Glu Ser Pro Glu Pro Asp Tyr Trp Leu Ser Ile Tyr Glu Leu Pro 
        435                 440                 445             


Ala Met Leu Phe Tyr Ala Tyr Leu Arg Glu Lys Asn Gly Lys Leu Leu 
    450                 455                 460                 


Lys Asp Tyr Lys Ser Ile Arg Glu Leu Ile Glu Asp Val Glu Lys Lys 
465                 470                 475                 480 


Ala Asp Glu Lys Asn Asp Arg Asp Lys Gly Ala Leu Met Ala Arg His 
                485                 490                 495     


Ile Asp Lys Glu Ile Ile Trp Thr Gln Thr Lys Leu Asp Glu Val Lys 
            500                 505                 510         


Arg Leu Glu Glu Lys Lys Val Ala Ala Tyr Gly Lys Lys Gly Arg Val 
        515                 520                 525             


Val Leu Lys Ser Gly Arg Met Ala Asp Leu Leu Ala His Asp Met Val 
    530                 535                 540                 


Arg Leu Gln Pro Ala Thr Lys Gly Ser Asp Lys Ile Thr Gly Ala Asn 
545                 550                 555                 560 


Phe Gln Ala Leu Gln Val Ser Leu Ala Tyr Phe Lys Arg Asp Ile Leu 
                565                 570                 575     


Ala Asp Val Phe Ser Arg Ala Met Leu Thr Thr Gly Asn His Arg His 
            580                 585                 590         


Pro Phe Leu Tyr Arg Ile Asp Val Ser His Cys Ser Ser Leu Arg Asp 
        595                 600                 605             


Phe Tyr Val Ala Tyr Leu Gly Glu Arg Arg Lys Tyr Phe Glu Asp Val 
    610                 615                 620                 


Ala Lys Lys Ile Thr Lys Asn Lys Leu Asn Thr Pro Cys His Ile Leu 
625                 630                 635                 640 


Arg Arg Leu Gln Arg Glu Gly Ser Gly Glu Glu Ala Gly Lys Asp Val 
                645                 650                 655     


Lys Pro Lys Phe Leu Pro Arg Gly Ile Phe Thr Gly Ser Ile Lys Ser 
            660                 665                 670         


Cys Leu Glu Lys Ser Ala Leu Asn Ile Asn Ile Arg Asn Ala Arg Asn 
        675                 680                 685             


Asp Val Lys Pro Ala Ile Asn Ala Ala Tyr Leu Ile Phe Met Tyr Tyr 
    690                 695                 700                 


Lys Glu Ile Glu Lys Gly Glu Phe Gln Gly Phe Tyr Gly Glu Lys Arg 
705                 710                 715                 720 


Arg Tyr Asp Ile Leu Glu Glu Gly Lys Pro Leu Asp Leu Asp Glu Arg 
                725                 730                 735     


Lys Lys Ala Leu Ala Ser Ile Lys Pro Ala Lys Ile Asp Val Ser Glu 
            740                 745                 750         


Ala Asn Met Pro Met Ser Lys Glu Glu His Leu Met Arg Lys Arg Tyr 
        755                 760                 765             


His Ala Val Cys Asn Asn Glu Ser Ala Ile Arg Met Tyr Gln Val Gln 
    770                 775                 780                 


Asp Ile Leu Leu Leu Leu Met Ala Lys Asp Ile Phe Lys Lys Ala Leu 
785                 790                 795                 800 


Ser Glu Val Val Met Ser Lys Lys Ile Gly Leu Glu Asn Leu Asn Gly 
                805                 810                 815     


Ile Phe Asp Ala Pro Val Asn Phe Val Lys Asn Phe Asp Asn Ile Lys 
            820                 825                 830         


Leu Thr Ala Thr Gly Ile Lys Ile Lys Asp Tyr Gly Lys Val Cys Arg 
        835                 840                 845             


Leu Gly Thr Asp Phe Lys Phe Asn Ser Leu Ile Lys Ala Phe His Lys 
    850                 855                 860                 


Val Tyr Ser Lys Ser Val Glu Met Asp Tyr Ser Asp Tyr Leu Lys Glu 
865                 870                 875                 880 


Glu Glu Glu Phe Glu Lys Tyr Arg Leu Asn Met Val Lys Leu Cys Arg 
                885                 890                 895     


Glu Val Glu Arg Gly Ile Thr Glu Asp Leu His Leu Ser Leu Asp Gly 
            900                 905                 910         


Lys Ser His Leu Ser Phe Asn Asp Asp Val Ile Lys Ser Tyr Asn Asp 
        915                 920                 925             


Lys Tyr Asn Val Phe Asn Gly Asp Asp Leu Thr Phe Phe Ile Asn Ala 
    930                 935                 940                 


Arg Asn Met Phe Met His Gly Asp Tyr Lys Tyr Glu Cys Val Lys Tyr 
945                 950                 955                 960 


Val Val Ser Glu His Phe Lys Gly Ser Leu Asn Asp Val Ser Phe Ala 
                965                 970                 975     


Lys Glu Thr Tyr Gly His Phe Cys Asn Leu Leu Glu Ser Met Arg Lys 
            980                 985                 990         


Lys Thr Gly Leu Arg Ile Asp Ile  
        995                 1000 


<210>  2031
<211>  1081
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2031

Met Gln Ala Gln Ser Leu Phe Asp Glu Tyr Lys His Leu Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Val Met Ser Ile Met Asn Ile Ile Thr Val Leu Asn His Ile 
            20                  25                  30          


His Gln Ile Ala Gly Leu Lys Arg Asn Glu Leu Gly Asp Asp Asp Asn 
        35                  40                  45              


Ile Tyr Ser His Pro Val Leu Lys Tyr Ile Ala Pro Glu Asn Asn Ser 
    50                  55                  60                  


Thr Thr Leu Pro Glu Lys Arg Asp Leu Ile Lys Glu Leu Leu Leu Glu 
65                  70                  75                  80  


Tyr Leu Pro Phe Leu Glu Ala Met Lys Asp Cys Tyr Lys Glu Val Lys 
                85                  90                  95      


Val Glu Lys Asp Lys Arg Asn Asn Lys Tyr Val Lys Asp Lys Lys Gln 
            100                 105                 110         


Val Phe Ile Arg Asn Tyr Ser Asp Ile Tyr Cys Ile Tyr Trp Thr Leu 
        115                 120                 125             


Tyr Asn Ile Phe Ser Thr Leu Ile Asn Tyr Arg Asp Lys Ser Cys His 
    130                 135                 140                 


Tyr Arg Phe Ile Pro Ser Lys Asp Gln Glu Glu Tyr Ser Lys Arg Thr 
145                 150                 155                 160 


Glu Tyr Asp Thr Val Arg Ile Ile Asn Lys Tyr Tyr Thr Tyr Ala Leu 
                165                 170                 175     


Arg Lys Thr Lys Glu Lys Tyr Gly Tyr Thr Thr Glu Gln Leu Ser Phe 
            180                 185                 190         


Ile Gln Asn Asn Arg Tyr Thr Asp Asp Lys Lys Val Asn Phe Asn Phe 
        195                 200                 205             


Phe Leu Ser Met Gln Ser Ser Asn Asn Asn Leu Ser His Val Gly Val 
    210                 215                 220                 


Ala Gln Leu Ile Cys Leu Phe Leu Gln Lys Lys Asp Val Asp Asn Phe 
225                 230                 235                 240 


Leu Glu Asn Leu Pro Ile Tyr Asp Asn Arg Tyr Cys Leu Gly Ile Asp 
                245                 250                 255     


Glu His Met Ile Ile Lys Arg Ser Leu Ala Leu His Ser Ile Lys Leu 
            260                 265                 270         


Pro Lys Glu Arg Leu Asn Ser Glu Lys Lys Asp Met Ala Ile Ala Met 
        275                 280                 285             


Asp Met Leu Asn Glu Leu Lys Arg Cys Pro Lys Glu Leu Phe Asn Thr 
    290                 295                 300                 


Leu Pro Phe Asp Lys Gln Glu Arg Phe Arg Ile Ile Ser Ser Asp His 
305                 310                 315                 320 


Lys Glu Val Leu Leu Met Arg Ser Thr Asp Arg Phe Val Pro Leu Ile 
                325                 330                 335     


Leu Gln Tyr Ile Asp Cys Asn Lys Lys Phe Lys Asp Ile Arg Phe His 
            340                 345                 350         


Val Asn Met Gly Lys Leu Arg Tyr Leu Phe Ser Pro Asn Lys Leu Cys 
        355                 360                 365             


Ile Asp Asn Gln Glu Arg Val Arg Met Leu Glu His Leu Leu Asn Gly 
    370                 375                 380                 


Tyr Gly Arg Ile Asp Glu Val Glu Tyr Leu Arg Lys Ala Pro Asn Gly 
385                 390                 395                 400 


Thr Phe Gly Asn Thr Asn Ile Pro Ile Lys Gly Phe Gly Glu Ile Glu 
                405                 410                 415     


Arg Asp Ser Ala Asp Ser Asn Asn Tyr Pro Tyr Ile Val Asp Thr His 
            420                 425                 430         


Thr His Tyr Ile Leu Asn Asn Asn Lys Val Glu Phe Cys Phe Cys Glu 
        435                 440                 445             


Asp Ser Lys Asn Lys Asn Val Phe Pro Thr Ile Glu Lys Glu Ile Asn 
    450                 455                 460                 


Gly Lys Trp Tyr Val Glu Lys Thr Ala Pro His Cys Arg Ile Ser Phe 
465                 470                 475                 480 


Phe Glu Ile Pro Ala Met Ala Phe His Met Phe Leu Cys Gly Ser Glu 
                485                 490                 495     


Lys Thr Glu Lys Leu Ile Lys Asp Val Tyr Asn Asn Tyr Ile Ser Leu 
            500                 505                 510         


Phe Asn Ala Leu Lys Asn Gly Ala Leu Thr Glu Glu Asn Tyr Lys Asp 
        515                 520                 525             


Phe Asn Ile Pro Glu Cys Asp Met Pro Lys Lys Ile Leu Asp Phe Leu 
    530                 535                 540                 


Lys Gly Lys Ala Glu Gly Lys Ser Ile Asp Gly Tyr Val Lys Asn Ile 
545                 550                 555                 560 


Leu Lys Lys Glu Leu Lys Asp Thr Arg Lys Arg Ile Glu Gln Ala Pro 
                565                 570                 575     


Ser Glu Lys Asp Gln Met Pro Ser Lys Arg Asn Lys Ile Gly Thr Lys 
            580                 585                 590         


Ser Tyr Lys Arg Val Leu Thr Gly Lys Leu Ala Asp Phe Leu Ala Lys 
        595                 600                 605             


Asp Ile Val Lys Tyr Gln Pro Thr Leu Cys Ala Gly Asp Asp Tyr Gly 
    610                 615                 620                 


Ile Asp Arg Met Thr Gly Met Asn Tyr Arg Ile Met Gln Ala Thr Ile 
625                 630                 635                 640 


Ala Thr Tyr Asn Asp Asp Asp Asp Phe Asp Thr Phe Tyr Asn Val Phe 
                645                 650                 655     


Lys Met Ala Gly Leu Val Asp Gly Asp Glu Arg Lys Asn His Pro Phe 
            660                 665                 670         


Leu Lys Lys Val Leu Leu Ser Lys Pro Gln Asn Thr Val Ala Phe Asn 
        675                 680                 685             


Ile Lys Tyr Leu Lys Glu Lys Glu Ile Tyr Leu Arg Asn Ile Glu Lys 
    690                 695                 700                 


Lys Asn Ile Ile Pro Pro Phe Val Asn Arg Glu Arg Asn Lys Trp Cys 
705                 710                 715                 720 


Glu Arg Asp Cys Glu Tyr Tyr Arg Ile Leu Gly Glu Asn Leu Leu Asp 
                725                 730                 735     


Leu Pro Ile Glu Leu Pro Arg Gln Met Phe Tyr Lys Asp Ile Arg Ala 
            740                 745                 750         


Gln Leu Glu Pro Leu Met Pro Glu Ile Asp Phe Ser Gln Thr Asn Thr 
        755                 760                 765             


Thr Tyr Leu Ile Ala Glu Tyr Leu Lys Arg Val Arg Gly Asp Asp Phe 
    770                 775                 780                 


Gln Glu Phe Tyr Ser Trp Glu Arg Asn Tyr Arg Tyr Ile Asp Phe Leu 
785                 790                 795                 800 


Lys Cys Ile Arg Asp Asp Asn Gly Arg Ile Cys Ala Gln Tyr Thr Thr 
                805                 810                 815     


Thr Glu Glu Arg Glu Ser Leu Trp Glu Asp Ser Lys Asn Arg Thr Ala 
            820                 825                 830         


Glu Tyr Lys Arg Ser Glu Glu Gln Lys Asn Glu Lys Lys Asp Lys Asn 
        835                 840                 845             


Phe Glu Asp Ser Leu Glu Glu Arg Ile Ser Ser Ser His Ile Lys Phe 
    850                 855                 860                 


Gln Asn Thr Glu Lys His Ile Arg Arg Tyr Lys Val Gln Asp Ala Leu 
865                 870                 875                 880 


Leu Phe Met Ile Ala Glu Lys Gln Phe Gly Lys Tyr Leu Asp Asp Ile 
                885                 890                 895     


Lys Ala Lys Asn Phe Lys Leu Lys Asp Ile Met Pro Asp Thr Asp Lys 
            900                 905                 910         


Gly Ile Leu Ser Glu Thr Met Pro Ile Asp Phe Thr Phe Thr Lys Lys 
        915                 920                 925             


Asn Ile Lys Tyr Asn Ile His Ala Lys Asn Leu Lys Phe Lys Glu Tyr 
    930                 935                 940                 


Gly Asp Leu Phe Ile Leu Ala Asn Asp Lys Arg Leu Glu Ser Leu Trp 
945                 950                 955                 960 


Lys Ile Leu Ala Thr Asp Thr Val Asn Lys Glu Glu Ile Ser Glu Glu 
                965                 970                 975     


Phe Ala Lys Tyr Asp Phe Cys Arg Pro Asp Ile Thr Lys Leu Val Leu 
            980                 985                 990         


Asp Phe Glu Lys Asp Val Leu Glu  Lys Tyr Pro Glu Ile  Ile Glu Glu 
        995                 1000                 1005             


Ala Glu  Lys Glu Tyr Lys Lys  Phe Asp Phe Lys Phe  Ile Leu Asp 
    1010                 1015                 1020             


Trp Leu  Ile Asn Lys Lys Lys  Leu Asn Tyr Gly Ile  Arg Asn Lys 
    1025                 1030                 1035             


Leu Leu  Leu Ile Arg Asn Ala  Phe Asn His Asn Ser  Tyr Pro Asp 
    1040                 1045                 1050             


Lys Lys  Tyr Ala Glu Val Arg  Glu Leu Pro Glu Ile  Ala Thr Asn 
    1055                 1060                 1065             


Leu Lys  Lys Thr Phe Asp Glu  Asn Ala Lys Lys Tyr  Glu 
    1070                 1075                 1080     


<210>  2032
<211>  1128
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2032

Met Glu Thr Gln Ile Ser Asn Ile Glu Asn Lys Tyr Arg Ile Leu Asn 
1               5                   10                  15      


Asp Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Val Phe Asn Ile Ser Asn His Ile Ala Lys Glu Phe Asn Leu Pro Leu 
        35                  40                  45              


Leu Pro Glu Glu Gly His Leu Lys Asn Ser Phe Leu Cys Gln Lys Glu 
    50                  55                  60                  


Asn Lys Lys Val Asn Trp Asn His Ile Phe Ser Lys Thr Asn Arg Phe 
65                  70                  75                  80  


Leu Ser Ile Leu Lys Val Phe Asp Val Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Lys Met Thr Asp Ser Glu Gly Lys Asp Phe Ala Leu Met Ser Asp 
            100                 105                 110         


Ser Leu Lys Ile Val Phe Gly Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Asn Gly Thr Ser Arg Lys Thr Thr Val 
    130                 135                 140                 


Ser Asp Glu Met Ser Leu Phe Leu Arg Thr Asn Phe Leu Arg Ala Ile 
145                 150                 155                 160 


Gln Tyr Thr Lys Glu Arg Phe Lys Gly Val Leu Asn Asp Glu Asp Tyr 
                165                 170                 175     


Gln Leu Val Ala Ser Lys Lys Val Leu Glu Ala Asp Asn Thr Ile Thr 
            180                 185                 190         


Val Glu Gly Leu Val Phe Leu Thr Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Thr Gly Leu Lys Gly Thr Gln Asn 
    210                 215                 220                 


Asn Ser Phe Ile Ser Thr Arg Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro His Asp Arg Phe Gln Ser Asp Asp Thr Arg Gln Ala Phe Ser 
                245                 250                 255     


Leu Asp Leu Ile Asn Glu Leu Thr Arg Cys Pro Lys Glu Leu Tyr Asn 
            260                 265                 270         


Ala Ile Thr Glu Glu Gly Lys Met Lys Phe Gln Pro Lys Leu Asp Glu 
        275                 280                 285             


Pro Gly Ile Lys Asn Leu Leu Asp Asn Ser Thr Asn Asn Lys Lys Lys 
    290                 295                 300                 


Ile Asp Ala Glu Asp Tyr Asp Glu Tyr Ile Glu Ser Leu Thr Lys Arg 
305                 310                 315                 320 


Ile Arg Tyr Asn Asn Arg Phe Ser Asp Phe Ala Leu Lys Tyr Ile Glu 
                325                 330                 335     


Glu Thr Asp Ile Leu Gly Asp Phe Arg Phe Gln Ile Asp Leu Gly Lys 
            340                 345                 350         


Leu Phe Val Asp Glu Tyr Asp Lys Phe Phe Asn Gly Glu Glu Val Pro 
        355                 360                 365             


Arg Arg Ile Ile Glu Asn Val Lys Ala Phe Gly Lys Leu Asn Asp Phe 
    370                 375                 380                 


Asn Asp Glu Ser Ile Leu Leu Ala Gln Ile Glu Asn Gly Tyr Pro Ser 
385                 390                 395                 400 


Lys Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Thr Glu Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Val Lys Val Asp Thr Ala Lys Leu Arg Ser Asn Ser 
            420                 425                 430         


Lys Gly Glu Pro Gly Lys Asn Leu Asn Gln Pro Leu Pro Glu Ala Phe 
        435                 440                 445             


Leu Ser Leu Asn Glu Leu Pro Lys Ile Ile Leu Leu Asp Tyr Leu Gln 
    450                 455                 460                 


Lys Gly Glu Pro Glu Gln Leu Ile Asn Asp Phe Ile Leu Ile Asn Asn 
465                 470                 475                 480 


Ser Lys Leu Met Lys Met Ser Phe Ile Glu Glu Ile Lys Asn Leu Leu 
                485                 490                 495     


Pro Lys Glu Trp Asn Glu Phe Arg Lys Arg Ala Asp Thr Arg Lys Gln 
            500                 505                 510         


Ala Ala Tyr Asn Asn Glu Thr Leu Ala Tyr Leu Leu Glu Arg Lys Gln 
        515                 520                 525             


Ile Leu Asn Gln Val Leu Val Ser Tyr Gln Leu Asn Asp Lys Gln Ile 
    530                 535                 540                 


Pro Gly Arg Ile Leu Asp Tyr Trp Leu Asn Ile Lys Glu Val Glu Glu 
545                 550                 555                 560 


Gly Arg Ala Val Ser Asp Arg Leu Lys Leu Met Lys Arg Asp Cys Met 
                565                 570                 575     


Ser Arg Leu Lys Ala Leu Glu Lys Phe Lys Ile Asp Arg Asn Arg Ser 
            580                 585                 590         


Lys Ile Pro Lys Thr Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile 
        595                 600                 605             


Val Asp Met Val Val Ser Glu Gly Ile Lys Lys Lys Ile Thr Ser Phe 
    610                 615                 620                 


Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Pro Glu 
625                 630                 635                 640 


Lys Lys Arg Leu Phe Ile His Ile Val Ile Arg Glu Leu Arg Leu Asn 
                645                 650                 655     


Gly Thr Gly Gly His Pro Phe Leu Phe Gln Leu Asn Phe Asp Lys Ile 
            660                 665                 670         


Asn Cys Thr Ser Asp Phe Tyr Ser Glu Tyr Leu Arg Glu Lys Gly His 
        675                 680                 685             


Lys Met Val Lys Glu Lys Asn Leu Lys Thr Gly Lys Ile Val Leu Thr 
    690                 695                 700                 


Asp His Ser Trp Met Ala Leu Thr Phe Tyr Lys Leu Glu Phe Asn Asp 
705                 710                 715                 720 


Lys Val Asp Lys Leu Met Thr Val Val Lys Leu Pro Leu Asn Lys Leu 
                725                 730                 735     


Asn Ile Pro Phe Thr Leu Arg Gln Leu Glu Gly Lys Thr Ile Asn Thr 
            740                 745                 750         


Leu Glu Gln Trp Leu Gln Asn Ile Thr Lys Gly Lys Asn Gln Asn Asp 
        755                 760                 765             


Gly Lys His Pro Val Asn Leu Pro Thr Asn Leu Phe Asp Glu Arg Leu 
    770                 775                 780                 


Thr Ala Cys Leu Gln Lys Glu Leu Asp Lys Lys Gln Ile Ile Tyr Pro 
785                 790                 795                 800 


Pro Tyr Ala Asn Trp Asn Glu Leu Phe Lys Thr Trp Trp Lys Ser Arg 
                805                 810                 815     


Asn Asp Ser Thr Gln Ser Phe Tyr Asn Ala Glu Arg Glu Tyr Ile Ile 
            820                 825                 830         


Phe Asp Glu Lys Val Asn Phe Tyr Pro Asn Arg Gln Glu Lys Phe Ala 
        835                 840                 845             


Asp Tyr Tyr His His Ala Val Lys Ala Ala Tyr Gln Lys Lys Arg Asn 
    850                 855                 860                 


Glu Arg Thr Leu Gln Gln Lys Asp Asp Lys His Leu Pro Asp Ile Leu 
865                 870                 875                 880 


Phe Ala Gln Val Glu Lys Thr Phe Lys Gln Thr Ile Ala Gly Thr Glu 
                885                 890                 895     


Lys Glu Ile Arg Met Val Gln Glu Glu Asp Arg Ile Met Leu Val Met 
            900                 905                 910         


Leu Glu Ser Leu Leu Glu Asp Gly Lys Lys Leu Gln Leu Lys Leu Ser 
        915                 920                 925             


Glu Ile Asn Thr Leu Leu Asn Ala Thr Thr Glu Ile Lys Gln Val Val 
    930                 935                 940                 


Thr Ala Lys Leu Ser Phe Asn Asp Ser Gly Glu Ile Ile Lys Asp Lys 
945                 950                 955                 960 


Thr Asn Pro Glu Ile Thr Lys Thr Ile Thr Ala Val Arg Lys Arg Lys 
                965                 970                 975     


Asp Tyr Ser Val Leu Arg Lys Phe Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Gly Tyr Phe Asp Gly Asp  Glu Ile Gln Phe Glu  Ser Leu Lys 
        995                 1000                 1005             


Ala Glu  Leu Asp Ala Tyr Asn  Lys Ala Lys Gln Glu  Val Leu Asp 
    1010                 1015                 1020             


Val Val  Phe Lys Leu Glu Lys  Lys Ile Ile Ala Lys  Asp Cys Asn 
    1025                 1030                 1035             


Gly Val  Gln Gln Leu Phe Ser  Asp Glu Thr Gly Asn  Leu Leu Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Thr Trp Leu  Lys Ser Lys 
    1055                 1060                 1065             


Gly Leu  Ile Gly Asp Ser Thr  Phe Thr Phe Leu Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Cys  Phe Ser His Asn Gln  Tyr Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Arg Phe  Ile Asp His Trp Glu  Thr Asn Arg Phe Ala  Leu Thr Ile 
    1100                 1105                 1110             


Ala Thr  Lys Tyr Asn His Glu  Ile Thr Arg Ile Met  Glu Lys Ile 
    1115                 1120                 1125             


<210>  2033
<211>  1047
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2033

Met Glu Glu Gln Phe Leu Gln Lys Glu Arg Asn Met Gly Asp Asn Pro 
1               5                   10                  15      


Tyr Tyr Phe Cys His Phe Ile Asn Met Ala His His Asn Val Asn Leu 
            20                  25                  30          


Ile Leu Glu Glu Ile Tyr Asn Ser Val Tyr Glu Lys Tyr Thr Gln Asp 
        35                  40                  45              


Lys Glu Glu Asn Ile Lys Ala Ile Cys Asn Ser Met Ile Ser Lys Ser 
    50                  55                  60                  


Arg Lys Asn Pro Asp Glu Lys Ala Lys Met Met Asn Met Cys Ile Arg 
65                  70                  75                  80  


His Phe Pro Phe Leu Asp Tyr Tyr Lys Glu Lys Asp Gln Asn Ser Asp 
                85                  90                  95      


Val Leu Thr Ile Leu Leu Asn Gln Phe Leu Val Pro Leu His Gly Leu 
            100                 105                 110         


Arg Asn Gln Phe Ser His Tyr Lys His Pro Gln Glu Ala Tyr Cys Ile 
        115                 120                 125             


Ser Gly Phe Asp Leu Leu Phe Glu Gln Ala Lys Thr Gly Ala Gln Met 
    130                 135                 140                 


Arg Met Lys Tyr Ser Asp Glu Asp Ile Ser Lys Val Lys Ser Lys Val 
145                 150                 155                 160 


Val Asn His Asp Ser Ile Leu Thr Glu Arg Gly Ile Leu Phe Phe Ile 
                165                 170                 175     


Cys Leu Phe Leu Asp Lys Arg Asn Ile Tyr Leu Phe Leu Ser Lys Ile 
            180                 185                 190         


Lys Gly Phe Arg Asp Arg Arg Pro Asp Glu Lys Tyr Lys Ser Ala Thr 
        195                 200                 205             


Leu Glu Val Phe Ser Gln Tyr Tyr Cys His Val Pro Tyr Arg Lys Leu 
    210                 215                 220                 


Asp Ser Ser Asp Val Ala Leu Asp Met Leu Asn Glu Leu Asn Arg Cys 
225                 230                 235                 240 


Pro Lys Ala Leu Tyr Asp Val Leu Ser Asp Glu Asp Arg Glu Arg Phe 
                245                 250                 255     


Ile Val Asp Asn Val Glu Asn Ala Asp Asn Arg Asp Glu Ile Ser Asp 
            260                 265                 270         


Glu Asp Asp Glu Glu Met Pro Arg Ser Val Met Lys Arg Ser Asp Asp 
        275                 280                 285             


Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Glu Lys Gln Asn Asn Leu 
    290                 295                 300                 


Asp Glu Ile Ser Phe His Leu Tyr Leu Gly Arg Lys Glu Ala Lys Pro 
305                 310                 315                 320 


Ala His Glu Lys Val Ile Asn Gly Glu Met Arg Thr His Lys Ile Leu 
                325                 330                 335     


Lys Asp Ile His Val Phe Gly Arg Leu Glu Asn Tyr Arg Asn Glu Glu 
            340                 345                 350         


Ile Cys Asn Ala Ile Lys Asn Arg Glu Asp Ile Glu Phe Tyr Ala Pro 
        355                 360                 365             


Ser Tyr Arg Ile Val Glu Asn Arg Ile Gly Leu Leu Leu Arg Arg Gln 
    370                 375                 380                 


Asn Asp Phe Thr Leu Glu Glu Ala Asn Glu Glu Lys Ile Phe Glu Gly 
385                 390                 395                 400 


Asn Leu Cys Pro Asp Val Ile Leu Ser Thr His Glu Leu Gly Ala Leu 
                405                 410                 415     


Phe Phe Tyr Asn Tyr Leu His Lys Lys Gly Trp Ile Glu Ser Ala Pro 
            420                 425                 430         


Tyr Leu Tyr Ile Arg Asn Phe Ile Ser Asp Phe Lys Arg Phe Ile Glu 
        435                 440                 445             


Asp Ile Lys Asn Gly Lys Leu Thr Pro Val Glu Ser Glu Asp Asp Phe 
    450                 455                 460                 


Tyr Leu Ile Lys Lys Lys Lys Arg Asp Glu Thr Lys Asp Asn Asp Lys 
465                 470                 475                 480 


Lys Ser Ile Ala Val Gln Glu Arg Arg Arg Glu Lys Leu Lys Glu Lys 
                485                 490                 495     


Leu Lys Gly Tyr His Leu Glu Pro Asp Trp Ile Pro Asp Ala Cys Arg 
            500                 505                 510         


Glu Tyr Met Leu Gly Tyr Lys Ala Asp Gln Lys Asp Tyr Tyr Thr Lys 
        515                 520                 525             


Gln Arg Phe Cys Ser Met Lys Lys Glu Thr Asp Ser Arg Ile Lys Gln 
    530                 535                 540                 


Ile Glu Ala Ile Arg Lys Arg Glu Asp Asn Ser Ile Ile Arg Gln Thr 
545                 550                 555                 560 


Arg Val Gly Glu Ile Ala Gln Glu Leu Ala Arg Asp Ile Val Phe Leu 
                565                 570                 575     


Ile Pro Pro Tyr Lys Asn Glu Lys Gly Ala Asp Thr Lys Ile Asn Asn 
            580                 585                 590         


Met Glu Phe Asp Val Leu Gln Lys Met Leu Ala Tyr Phe Pro Leu Asn 
        595                 600                 605             


Lys Lys Asp Ile Tyr Pro Phe Leu Lys Asn Ile Arg Asn Trp Asp Lys 
    610                 615                 620                 


His Pro Phe Leu Lys Tyr Thr Leu His Thr Glu His Gln Ser Leu Leu 
625                 630                 635                 640 


Asp Phe Tyr Gln Asp Tyr Leu Asn Cys Lys Lys Arg Trp Ile Ser Lys 
                645                 650                 655     


Asn Ile Arg Tyr Asp Lys Gln Lys Gly Asn Tyr Leu Val Asp Ala Asn 
            660                 665                 670         


Lys Thr Glu Gln Glu Cys Arg Tyr Phe Leu Lys Thr Asp Lys Leu Arg 
        675                 680                 685             


Thr Ala Lys Glu Lys Glu Tyr Phe Glu Glu Pro Asp Lys Pro Val Tyr 
    690                 695                 700                 


Leu Pro Thr Gly Phe Phe Val Asp Pro Ile Val Glu Ala Met Arg Lys 
705                 710                 715                 720 


Asn Gly Tyr Glu Leu Lys Glu Asn Ser Asn Ile Val Gly Cys Leu Lys 
                725                 730                 735     


Ile Tyr Phe Val Ser Lys Ile Gln Pro Met Tyr Asp Leu Ser Arg Tyr 
            740                 745                 750         


Tyr Thr Tyr Tyr Asp Gly Lys Glu Glu Arg Ser Met Gln Leu Asp Asp 
        755                 760                 765             


Leu Lys Val Phe Ile Lys Glu Lys Phe Gly Asn Lys Arg Thr Asp Asp 
    770                 775                 780                 


Asn Thr Ile Arg Phe Leu Lys Lys Ala Ala Lys Arg Ile Arg Glu Asn 
785                 790                 795                 800 


Glu Ser Glu Ile Leu Val Arg Gln Met Asp Asp Cys Ala Leu Phe Leu 
                805                 810                 815     


Met Val Asn Asp Leu Leu Glu Gly Gly Lys Phe Asn Asp Glu Asp Ile 
            820                 825                 830         


Glu Asn Ile Gly Tyr Asn Lys His His Asn Leu Leu Asp His Glu Tyr 
        835                 840                 845             


Asp Met Cys Glu Thr Ile Tyr Gly Arg Lys Val Thr Ala Arg Leu Pro 
    850                 855                 860                 


Ile Lys Arg Tyr Gly Glu Phe Arg Arg Phe Met Lys Asp Arg Arg Leu 
865                 870                 875                 880 


Gln Asn Leu Val Lys Tyr Tyr Pro Gly Asp His Glu Thr Pro Ile Pro 
                885                 890                 895     


Ser Gly Ile Pro Glu Ser Gly Lys Ala Met Glu Lys Asn Lys Lys Tyr 
            900                 905                 910         


Thr Tyr Ser Asn Leu Cys Asp Glu Leu Glu Ile Tyr Asp Lys Glu Arg 
        915                 920                 925             


Asp Asn Val Leu Asn Leu Ile Tyr Glu Val Asp Lys Ile Leu Val Asp 
    930                 935                 940                 


His Phe Pro Asp Lys Ile Met Lys Glu Glu Asp Gly Tyr Tyr Glu His 
945                 950                 955                 960 


Tyr His Cys Leu Asp Phe Ala Lys Lys Glu Phe Gly Leu Glu Ser Asp 
                965                 970                 975     


Val Glu Leu Leu Ser Gln Asp Asn Phe Lys Asp Leu Arg Asn Ala Leu 
            980                 985                 990         


Tyr His Asn Gln Ile Pro Tyr Asn  Asp Trp Val Ala Asp  Lys Ile Ser 
        995                 1000                 1005             


Lys Asp  Thr Glu Glu Pro Met  Tyr Val Arg Arg Ile  Phe Ser Phe 
    1010                 1015                 1020             


Ile Arg  Thr Val Tyr Ser Arg  Leu Leu Asp Gln Ile  Lys Ile Lys 
    1025                 1030                 1035             


Ile Glu  Lys Asp Glu Tyr Lys  Cys Lys 
    1040                 1045         


<210>  2034
<211>  960
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2034

Met Glu Ile Leu Thr Ile Pro Glu Val Ile Lys Cys Arg Thr Leu Ser 
1               5                   10                  15      


Asp Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Val Leu Asn Ile Ser Asn His Ile Ala Lys Glu Phe Lys Leu Pro Leu 
        35                  40                  45              


Leu Pro Glu Glu Ala His Leu Lys Asn Ser Phe Leu Cys Lys Lys Glu 
    50                  55                  60                  


Asn Lys Lys Ile Asp Trp Asn His Val Tyr Ala Arg Thr Ile Arg Phe 
65                  70                  75                  80  


Leu Ser Val Met Lys Val Phe Asp Ala Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Lys Thr Ile Asp Trp Glu Gly Lys Asp Phe Ala Ser Met Cys Asp 
            100                 105                 110         


Thr Leu Asn Ile Val Phe Ser Glu Leu Gln Glu Phe Ser Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Glu Thr Lys Arg Lys Thr Thr Val 
    130                 135                 140                 


Ser Asp Glu Leu Ala Leu Phe Leu Arg Thr Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Glu Tyr Thr Lys Val Arg Phe Lys Gly Ile Leu Asn Asp Glu Asp Tyr 
                165                 170                 175     


Gln Leu Val Val Ser Lys Lys Met Leu Glu Thr Asn His Thr Ile Thr 
            180                 185                 190         


His Glu Gly Leu Val Phe Leu Thr Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Arg Phe Ile Arg Lys Ile His Gly Leu Ser Gly Pro Lys Asp 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Cys Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro Gln Glu Gln Phe Arg Ser Asp Asn Arg Arg Gln Ala Ile Ser 
                245                 250                 255     


Leu Glu Leu Met Asn Glu Leu Lys Lys Cys Pro Lys Val Leu Tyr His 
            260                 265                 270         


Val Ile Thr Glu Glu Trp Lys Gln Lys Leu Lys Ser Val Pro Glu Glu 
        275                 280                 285             


Leu Glu Thr Lys Asn Leu His Tyr Asn Thr Lys Arg Glu Thr Lys Ile 
    290                 295                 300                 


Glu Phe Glu Asp Tyr Asp Leu Tyr Ile Glu Ser Leu Thr Lys Gln Val 
305                 310                 315                 320 


Arg Tyr Asn Asn Arg Phe Ser Glu Phe Ala Leu Lys Tyr Ile Asp Glu 
                325                 330                 335     


Thr Gly Ile Phe Ser Glu Phe Arg Phe Gln Leu Asp Leu Gly Lys Ile 
            340                 345                 350         


Leu Val Asp Glu Tyr Leu Lys Asn Phe Asn Asp Glu Arg Val Gln Arg 
        355                 360                 365             


Cys Ile Ile Glu Asn Ala Lys Ala Phe Gly Lys Leu Asn Asp Tyr Thr 
    370                 375                 380                 


Asn Glu Thr Lys Val Met Ser Leu Ile Val Asn Gly Pro Pro Leu Lys 
385                 390                 395                 400 


Ser Phe Asp Arg Phe Ala Pro His Tyr Asn Ile Glu Ser Asn Lys Ile 
                405                 410                 415     


Gly Ile Ser Thr His Glu Val Thr Ala Lys Leu Val Pro Asn Ser Lys 
            420                 425                 430         


Gly Glu Pro Ala Lys Lys Leu His Gln Pro Leu Pro Glu Ala Phe Leu 
        435                 440                 445             


Ser Leu His Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu Gln Lys 
    450                 455                 460                 


Gly Glu Pro Glu Lys Leu Ile Asn Glu Phe Ile Leu Val Asn Asn Ser 
465                 470                 475                 480 


Lys Leu Met Asn Met Ser Phe Ile Glu Glu Val Lys Asn Gln Leu Pro 
                485                 490                 495     


Lys Glu Trp Asp Lys Phe Gln Arg Arg Thr Asn Ala Lys His Glu Leu 
            500                 505                 510         


Ala Tyr Asp Glu Asn Thr Leu Ala Phe Leu Leu Gln Arg Lys Gln Ile 
        515                 520                 525             


Leu Asn Lys Thr Leu Leu Ala Tyr Gln Leu Asn Asp Lys Gln Ile Pro 
    530                 535                 540                 


Thr Arg Ile Leu Asp Tyr Trp Leu Asn Ile Ser Asp Ala Asp Glu Glu 
545                 550                 555                 560 


Arg Ala Ile Ser Asn Arg Leu Lys Ser Ile Lys Arg Asp Cys Met Ser 
                565                 570                 575     


Arg Leu Lys Ala Leu Ser Lys Phe Asn Glu Asn Gly Asn Arg Asn Lys 
            580                 585                 590         


Ile Pro Gly Ile Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile Ile 
        595                 600                 605             


Asp Met Val Val Ser Glu Gly Lys Lys Arg Lys Ile Thr Ser Phe Tyr 
    610                 615                 620                 


Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Gly Asp Pro Asp Lys 
625                 630                 635                 640 


Lys Gln Leu Phe Ile His Ile Val Thr Lys Glu Leu Lys Leu Asn Asp 
                645                 650                 655     


Pro Gly Gly His Pro Phe Leu Asp Lys Leu Asp Leu Gln Lys Ile Asn 
            660                 665                 670         


Ser Thr Thr Gly Phe Tyr Glu Ile Tyr Leu Gln Glu Lys Gly His Lys 
        675                 680                 685             


Met Val Pro Glu Asn Asn Pro Lys Thr Gly Lys Val Ile Tyr Thr Asp 
    690                 695                 700                 


His Ser Trp Met Ala Leu Thr Phe Tyr Lys Ile Glu Phe Asn Asp Lys 
705                 710                 715                 720 


Val Asp Met Leu Met Thr Val Val Lys Leu Pro Leu Lys Lys Leu Asn 
                725                 730                 735     


Ile Pro Phe Thr Leu Arg Gln Leu Ser Gly Lys Thr Asn Asn Thr Leu 
            740                 745                 750         


Lys Gln Trp Leu Asn Asn Leu Thr Gln Gly Lys Lys Arg Asn Asp Gly 
        755                 760                 765             


Lys Arg Pro Ile Asn Leu Pro Thr Asn Leu Phe Asp Glu Arg Leu Ala 
    770                 775                 780                 


Glu Leu Leu Arg Lys Asp Leu Asp Asn Lys Lys Ile Val Tyr Trp Pro 
785                 790                 795                 800 


Tyr Ala Asn Trp Asn Glu Leu Phe Lys Thr Trp Trp Ser Ser Arg Asn 
                805                 810                 815     


Asp Gly Leu Gln Ser Phe Tyr Asn Ala Glu Arg Glu Tyr Arg Ile Phe 
            820                 825                 830         


Asp Glu Lys Val Asn Phe Tyr Pro Asn Arg Lys Glu Asn Phe Ala Asp 
        835                 840                 845             


Tyr Tyr Gln His Ala Leu Lys Leu Ala Phe Gln Lys Lys Gln Ser Lys 
    850                 855                 860                 


Arg Ile Leu Glu Gln Met Tyr Asp Gln His Leu Pro Asp Ile Leu Phe 
865                 870                 875                 880 


Asp Gln Val Glu Lys Thr Phe Arg His Thr Ile Ala Glu Thr Glu Lys 
                885                 890                 895     


Glu Ile Arg Ile Leu Gln Glu Glu Asp His Ile Met Leu Leu Met Leu 
            900                 905                 910         


Glu Ser Leu Leu Asp Asp Gly Ser Lys Gln Gln Leu Lys Leu Ser Glu 
        915                 920                 925             


Ile Arg Thr His Leu Asn Arg Thr Thr Asn Ile Arg Gln Val Val Lys 
    930                 935                 940                 


Gly Lys Leu Ser Phe Asp Asp Ser Gly Glu Leu Ile Lys Asp Asn Thr 
945                 950                 955                 960 


<210>  2035
<211>  1094
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2035

Met Glu Ala Asn Glu Gln Asn Gln Glu Asn Arg Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Asn Asn His Ile Ala Ala Asp Phe Gly Gln Ala Val 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ser Gly Phe Leu Cys Asn Lys Glu 
    50                  55                  60                  


Ile Lys Lys Leu Asn Trp Asn His Ile Tyr Ala Lys Thr Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ile Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Val Asn Ser Asp Lys Glu Gly Lys Asp Phe Ala Ala Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Ser Glu Leu Gln Asp Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Glu Asn Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Ala Glu Leu Thr Asp Met Leu Thr Ile Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Thr Asp Ala Asp Tyr 
                165                 170                 175     


Glu Leu Val Glu Thr Lys Gln Val Val Thr Thr Gly Asn Ile Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Met Phe Leu Glu Arg Glu His 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asn Leu Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Gly 
            260                 265                 270         


Val Ile Thr Asp Glu Glu Lys Met Gln Phe Arg Pro Glu Leu Asp Glu 
        275                 280                 285             


Leu Asp Ile Glu Lys Leu Ile Ala Asn Ser Thr Asn Asp Asp Glu Arg 
    290                 295                 300                 


Glu Arg Ile Leu Asp Glu Ile Gly Tyr Glu Glu Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg Tyr Asn Asn Arg Phe Pro Tyr Phe Ala Met Arg 
                325                 330                 335     


Phe Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Arg Tyr Thr Lys Gln Leu Ala Gly Glu 
        355                 360                 365             


Gln Thr Glu Arg Val Val Leu Glu Asn Val Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asp Pro Glu Leu Ile Gln Gln Lys Ile Asp Asn Gln 
385                 390                 395                 400 


Gln Arg Thr Asp Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Ile Ala Ile Leu Ile 
            420                 425                 430         


Pro Lys Ser Lys Pro Glu Ser Lys Val Gly Asn Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Asp Tyr Leu Gln Lys Gly Lys Ala Glu Glu Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Ile Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Leu Lys Leu Pro Ala Asn Trp Asn Glu Phe Ala Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asp Ala Ala Met Glu Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Asp Val Leu Ile Thr Tyr Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Asp Val Glu Asp Asn Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Leu Glu Lys His Lys Leu 
            580                 585                 590         


Asp Lys Ser Val Lys Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Met Val Ser Lys Glu Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Ala Asp Thr Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Val Leu Glu Gly Asp Gly His Pro Phe Leu Thr Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Glu Leu Tyr Met Asn 
        675                 680                 685             


Ala Lys Val Gln Tyr Leu Ile Gln Phe Tyr Lys Pro Ser Lys Asp Lys 
    690                 695                 700                 


Val Asp Lys Arg Gly Arg Pro Thr Thr Glu Val Lys Leu Pro Pro Leu 
705                 710                 715                 720 


Asp Lys Arg Ser Asn Ile Pro Phe Thr Ile Arg Gln Trp Asp Glu Lys 
                725                 730                 735     


Glu Lys Tyr Asn Leu Asn Ala Trp Leu Arg Asn Val Thr Val Gly Lys 
            740                 745                 750         


Asn Thr Lys Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe 
        755                 760                 765             


Asp Glu Thr Leu Cys Asp Leu Leu Ser Gln Gln Leu Asp Ala Arg Thr 
    770                 775                 780                 


Val Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Leu Trp 
785                 790                 795                 800 


Trp Lys Thr Arg Asp Asp Ala Thr Gln Asp Phe Tyr Gln Ser Glu Arg 
                805                 810                 815     


Glu Tyr Asp Ile Tyr Glu Glu Lys Val Glu Phe Lys Ile Asp Ser Ser 
            820                 825                 830         


Gly His Phe Ala Asp Tyr Tyr Lys Lys Ala Leu Ser Lys Ala Tyr Asn 
        835                 840                 845             


Arg Leu Lys Ala Glu Arg Glu Ile Ala Arg Arg Thr Asn Lys Arg Leu 
    850                 855                 860                 


Pro Pro Ile Glu His Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile 
865                 870                 875                 880 


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
                885                 890                 895     


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asp Ser Gly Asn Leu Lys 
            900                 905                 910         


Leu Ser Thr Ile Lys Thr Ser Leu Asn Asn Thr Thr Gln Ile Lys Gln 
        915                 920                 925             


Lys Ile Leu Asn Lys Thr Ile Val Ala Glu Arg Lys Gln Lys Asn Tyr 
    930                 935                 940                 


Thr Glu Leu Arg Lys Tyr Val His Asp Arg Arg Leu Pro Asn Leu Phe 
945                 950                 955                 960 


Glu Tyr Val Glu Ala Asp Glu Ile Leu Leu Glu Trp Leu Leu Asp Glu 
                965                 970                 975     


Leu Met Ala Tyr Asn Ala Ala Lys Gln Gln Val Phe Asp Thr Ile Phe 
            980                 985                 990         


Met Leu Glu Lys Arg Ile Ile Glu  Thr Asp Pro Gln Glu  Leu Lys Ser 
        995                 1000                 1005             


Leu Phe  Thr Asn Glu Lys Gly  Gln Val Gln Thr Gly  Asn Ile Gln 
    1010                 1015                 1020             


His Lys  Pro Tyr Val Gln Trp  Leu Lys Asn Lys Gly  Leu Ile Asn 
    1025                 1030                 1035             


His Asn  Glu Lys Leu Phe Ile  Asn Met Val Arg Asn  Cys Phe Ser 
    1040                 1045                 1050             


His Asn  Gln Phe Pro Gln Arg  Glu Thr Met Glu Leu  Leu Ile Ser 
    1055                 1060                 1065             


Glu Trp  Gly Ala Gly Lys Ile  Ala Thr Gln Ile Leu  Thr Val Tyr 
    1070                 1075                 1080             


Asn Gln  Leu Ile Thr Asn Ile  Ile Asn Lys Ile 
    1085                 1090                 


<210>  2036
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2036

Met Glu Thr Lys Gln Gln Val Gly Lys Gly Ile Ser Tyr Asp His Arg 
1               5                   10                  15      


Arg Pro Asp Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asp Gly Val Ile Gln Glu Phe Ala Met Arg Leu Asn Arg 
        35                  40                  45              


Glu Tyr Asp Pro Glu Asn Lys Asn Gln Ser Leu Phe Ser Tyr Phe Asn 
    50                  55                  60                  


Ile Asn Ala Ser Phe Thr Asp Trp Glu Arg Gly Val Asn Ile Leu Lys 
65                  70                  75                  80  


Glu Tyr Trp Pro Met Met Glu Phe Ile Asp Arg Pro Ala Thr Asp Lys 
                85                  90                  95      


Gln Phe Glu Ala Glu Lys Pro Glu Asn Arg Glu Ala Ala Lys Arg Lys 
            100                 105                 110         


Tyr Phe Leu Ala Thr Leu Gly Ala Leu Leu Thr Ser Ile Lys Asp Leu 
        115                 120                 125             


Arg His Tyr Tyr Thr His Tyr Tyr His Pro Pro Val His Leu Asn Asp 
    130                 135                 140                 


Asp Leu Phe Leu Phe Leu Asp His Ala Leu Leu Tyr Thr Ala Phe Asp 
145                 150                 155                 160 


Val Lys Lys Thr Lys Met Lys Asp Asp Lys Thr Arg Gln Leu Leu Asn 
                165                 170                 175     


Gln Asn Leu Ser Leu Glu Leu Glu Lys Leu Lys Lys Leu Lys Val Glu 
            180                 185                 190         


Glu Leu Lys Lys Lys Lys Glu Lys Gly Ile Lys Val Asn Leu Gln Asp 
        195                 200                 205             


Glu Lys Gly Ile Leu Asn Ala Ile Tyr Asn Asp Ala Phe Ala His Ile 
    210                 215                 220                 


Ile Thr Lys Glu Lys Asp Ser Asp Lys Asp Lys Leu Glu Thr Arg Tyr 
225                 230                 235                 240 


Lys Ser Ile Leu Pro Gln Asp Glu Ala Ala Glu Thr Gly Ile Asn Ile 
                245                 250                 255     


Ser Ile Ser Gly Leu Ile Phe Leu Leu Ser Leu Phe Leu Ser Arg Lys 
            260                 265                 270         


Glu Ile Glu Gln Leu Lys Ser Asn Ile Glu Gly Tyr Lys Gly Lys Val 
        275                 280                 285             


Leu Asn Ile Glu Thr Glu Val Asp Arg Lys His Asn Ser Leu Lys Tyr 
    290                 295                 300                 


Met Ala Thr His Trp Val Phe Ser Ile Leu Ala Phe Lys Gly Leu Lys 
305                 310                 315                 320 


Gln Arg Leu Thr Asn Ser Phe Glu Lys Glu Ser Leu Leu Ile Gln Met 
                325                 330                 335     


Met Asp Glu Leu Asn Lys Val Pro Asp Glu Leu Tyr Gln Thr Leu Ser 
            340                 345                 350         


Glu Thr Ala Lys Lys Glu Phe Leu Glu Asp Ile Asn Glu Tyr Val Ser 
        355                 360                 365             


Glu Gly Asp Asp Asn Glu Lys Ala Thr Tyr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Ser Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gln Phe Pro Thr Leu Lys Phe Gln Ile Phe Val Gly 
                405                 410                 415     


Gln Tyr Leu His Asp Asn Arg Pro Lys Thr Leu Ala Ser Asn Gly Met 
            420                 425                 430         


Thr Ala Gln Arg Met Ile Lys Glu Lys Ile Asn Leu Phe Gly Asn Leu 
        435                 440                 445             


Ser Glu Val Thr Lys His Lys Ser Asp Phe Phe Glu Lys Glu Ser Ala 
    450                 455                 460                 


Ala Gln Gly Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Trp Ala Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Val Tyr Ile Asp Met Ile Gly Lys Glu Gly Lys Ala 
                485                 490                 495     


Lys Glu Ile Gln Val Gln Ile Asn Lys Tyr Arg Lys Gln Leu Asn Pro 
            500                 505                 510         


Ala Pro Gln Arg Asp Lys Arg Ile Ser Lys Lys Glu Ile Ile Glu Gln 
        515                 520                 525             


Leu Tyr Lys Glu Lys Val Val Tyr Gly Asp Pro Thr Leu Met Leu Ser 
    530                 535                 540                 


Ala Asn Glu Leu Met Ala Leu Leu Tyr Glu Leu Ile Val Asn Gly Lys 
545                 550                 555                 560 


Ser Gly Ala Glu Leu Glu Asn Lys Ile Val Glu Gln Ile Ile Ala Arg 
                565                 570                 575     


Tyr Glu Gln Ile Glu Ala Tyr Asp Pro Thr Thr Gln Gln Leu Pro Thr 
            580                 585                 590         


Asn Gln Met Pro His Lys Leu Gln Lys Ser Arg Lys Asp Ser Lys Val 
        595                 600                 605             


Thr Asp Thr Asp Lys Leu Leu Lys Thr Ile Asp Lys Glu Ile Asp Glu 
    610                 615                 620                 


Gly Asn Lys Lys Leu Glu Leu Ile Ala Cys His Arg Lys Glu Trp Glu 
625                 630                 635                 640 


Glu Ala Glu Gln Arg Lys Lys Ser Gly Lys Arg Asn Asn Pro Gly Thr 
                645                 650                 655     


Lys Ser Arg Lys His Leu Phe Tyr Ala Ser Glu Met Gly Glu Glu Ala 
            660                 665                 670         


Thr Trp Ile Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Pro Ala Arg 
        675                 680                 685             


Ala Glu Trp Lys Gly Thr His His Ser Glu Leu Gln Arg Leu Leu Ala 
    690                 695                 700                 


Phe Tyr Ser Thr Gln Arg Leu Glu Ala Trp Gln Leu Val Glu Ser Val 
705                 710                 715                 720 


Trp Thr Ala Asn Thr His Ser Phe Trp Glu Glu Asn Phe Lys Glu Ala 
                725                 730                 735     


Phe Tyr Lys Pro Glu Phe Glu Asn Phe Tyr Gly Ala Tyr Ile Glu Ile 
            740                 745                 750         


Arg Thr Lys Ile Leu Thr Thr Cys Arg Ser Ile Leu Glu Asn Asn Pro 
        755                 760                 765             


Glu Ala Thr Met Asn Asn Asp Thr Glu Lys Glu Trp Asp Lys Val Phe 
    770                 775                 780                 


Thr Leu Phe Asp Lys Arg Leu Tyr Arg Thr Ser Thr Thr Asp Glu Gln 
785                 790                 795                 800 


Lys Lys Gln Leu Leu Thr Lys Pro Phe Ala Phe Pro Arg Gly Leu Phe 
                805                 810                 815     


Asp Asp Lys Pro Thr Phe Leu Pro Gly Ser Lys Pro Asn Glu Asn Pro 
            820                 825                 830         


Glu Arg Phe Ala Ala Trp Tyr Ser Tyr Gly Tyr Thr Tyr Ser Gly Lys 
        835                 840                 845             


Phe Gln Ser Phe Tyr Asp Met Pro Arg Asn Tyr Ser Asp Trp Tyr Lys 
    850                 855                 860                 


Lys Leu Lys Glu Asp Gly Lys Leu Pro Arg Leu Asp Lys Lys Thr Glu 
865                 870                 875                 880 


Gln Glu Lys Ile Leu Arg Phe Arg Met Asp Cys Asp Leu Asn Ile Lys 
                885                 890                 895     


His Ile Arg Phe Gln Asp Ile Tyr Val Lys Leu Met Val Asp Ser Leu 
            900                 905                 910         


Tyr Lys Ala Val Phe Gly Gln Gln Pro Glu Phe Asp Leu Ser His Leu 
        915                 920                 925             


Tyr Asp Thr Arg Ser Glu Arg Tyr Glu Asn Asn Thr Ile Ala Gln Arg 
    930                 935                 940                 


Gln Lys Ser Arg Gln Glu Gly Asp Asn Ser Asp Asn Ala Ile Asn Glu 
945                 950                 955                 960 


Asn Tyr Val Trp Asn Lys Thr Phe Ala Ile Ser Leu Tyr Asn Gly Arg 
                965                 970                 975     


Ile Thr Glu Ser Gln Val Lys Leu Lys Asp Val Gly Lys Phe Arg Arg 
            980                 985                 990         


Phe Ala Thr Asp Pro Arg Val Gln  Thr Leu Ile Ser Tyr  Asp Asp Thr 
        995                 1000                 1005             


Arg Thr  Trp Thr Lys Leu Glu  Ile Glu Asn Glu Leu  Asp Asn Lys 
    1010                 1015                 1020             


Ala Asp  Ala Tyr Glu Pro Ile  Arg Arg Thr Gln Ser  Leu Lys Ala 
    1025                 1030                 1035             


Ile Gln  Gln Leu Glu Lys Asn  Ile Leu Lys Lys Asn  Gly Phe Asn 
    1040                 1045                 1050             


Gly Lys  Gln His Pro Glu Glu  Leu Lys His Asn Gly  Asn Pro Asn 
    1055                 1060                 1065             


Phe Arg  Lys Tyr Ile Ala Asn  Gly Leu Leu Lys His  Arg Thr Asp 
    1070                 1075                 1080             


Ile Arg  Gln Glu Glu Leu Ala  Leu Ile Ser Asp Thr  Glu Phe Gln 
    1085                 1090                 1095             


Glu Ile  Gly Leu Glu Arg Ile  Arg Gln Thr Asn Pro  Leu Ile Gln 
    1100                 1105                 1110             


Lys Ala  Tyr Leu Leu Ile Leu  Leu Arg Asn Lys Phe  Gly His Asn 
    1115                 1120                 1125             


Gln Leu  Pro Asp Gln Glu His  Phe Arg Leu Met Arg  Ser Ile Tyr 
    1130                 1135                 1140             


Pro Tyr  Asn Gln Gln Glu Ser  Tyr Ser Ala Tyr Phe  Asn His Val 
    1145                 1150                 1155             


Ile Thr  Gln Ile Ile Glu Glu  Leu Asn Thr 
    1160                 1165             


<210>  2037
<211>  1118
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2037

Met Glu Thr Ile Glu Lys Ala Glu His Lys Gly Leu Asn Val Tyr Lys 
1               5                   10                  15      


Thr Leu Lys Ser Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala 
            20                  25                  30          


Arg Ser Asn Ile Phe Ser Ile Asn Asn Ser Val Ala His Lys Ile Lys 
        35                  40                  45              


Ile Ser Thr Leu Pro Asp Glu Glu Lys Ile Leu Asp Ser Phe Leu Cys 
    50                  55                  60                  


Asn Asn Asn Arg Lys His Leu Asn Trp Asn Leu Ala His Ser Ile Ala 
65                  70                  75                  80  


Val Lys Phe Leu Pro Ile Ile Lys Val Phe Asp Phe Glu Ser Leu Pro 
                85                  90                  95      


Lys Ser Glu Arg Thr Gly Asp Leu Asn Asn Leu Asn Thr Gly Lys Asp 
            100                 105                 110         


Phe Ala Ala Met Ala Ala Ser Leu Arg Cys Leu Phe Arg Glu Ile Gln 
        115                 120                 125             


Glu Phe Arg Asn Asp Tyr Ser His Tyr Tyr Ser Ile Ala Asn Gly Thr 
    130                 135                 140                 


Lys Arg Lys Thr Ile Ile Ser Gly Glu Leu Ala Glu Phe Leu Arg Leu 
145                 150                 155                 160 


Asn Phe Ala Arg Ala Ile Glu Tyr Thr Lys Glu Arg Phe Asn Gly Val 
                165                 170                 175     


Leu Asn Asp Asp Asp Phe Glu Pro Val Lys Glu Arg Val Leu Val Asn 
            180                 185                 190         


Gln Asp Asn Thr Ile Thr Thr Asp Gly Phe Val Phe Leu Ile Ser Met 
        195                 200                 205             


Phe Leu Glu Arg Glu His Ala Phe Gln Phe Ile Gly Glu Ile Lys Gly 
    210                 215                 220                 


Leu Lys Gly Thr Gln Phe Asn Ser Phe Ile Ala Thr Arg Glu Val Leu 
225                 230                 235                 240 


Met Ala Phe Cys Ala Lys Leu Pro His Asp Arg Phe Val Ser Glu Asp 
                245                 250                 255     


Lys Lys Gln Ala Phe Thr Leu Asp Ile Ile Asn Thr Leu Asn Arg Cys 
            260                 265                 270         


Pro Lys Glu Leu Tyr Gly Val Ile Thr Asp Glu Glu Arg Lys Ala Phe 
        275                 280                 285             


Lys Pro Cys Leu Asp Lys Leu Asn Leu Glu Asn Leu Leu Asp Asn Ser 
    290                 295                 300                 


Thr Asn Asp Lys Ala Asp Val Glu Asp Tyr Asp Lys Tyr Ile Glu Ala 
305                 310                 315                 320 


Leu Thr Arg Lys Ile Arg His Ser Asn Arg Phe Ser Tyr Phe Ala Leu 
                325                 330                 335     


Lys Phe Ile Asp Glu Thr Asp Ile Phe Ser Lys Leu Arg Phe Gln Ile 
            340                 345                 350         


Asn Leu Gly Lys Leu Leu Ile Asp Glu Tyr Glu Lys Pro Ile Asn Arg 
        355                 360                 365             


Glu Met Tyr Pro Arg Ser Ile Val Gln Asp Val Lys Ala Phe Gly Lys 
    370                 375                 380                 


Leu Ser Asp Phe Glu Asp Gly Ala Glu Val Leu Lys Gln Ile Asp Lys 
385                 390                 395                 400 


Asp Gly Asn Ser Leu Gly Phe Glu Gln Tyr Ala Pro Phe Tyr His Thr 
                405                 410                 415     


Lys Asn Asn Lys Ile Gly Leu His Thr Asn Asn Ala Lys Ala Ile Val 
            420                 425                 430         


Ile His Lys Pro Asn Ser Gln Ser Lys Val Lys Lys Ser Leu Lys Gln 
        435                 440                 445             


Ala Leu Pro Glu Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile 
    450                 455                 460                 


Val Leu Glu His Leu Glu Lys Gly Lys Ser Glu Glu Leu Ile Asn Asp 
465                 470                 475                 480 


Phe Val Leu Ala Cys Asn Ser Lys Ile Thr Asn Lys Gln Phe Ile Asp 
                485                 490                 495     


Glu Val Lys Arg Lys Leu Pro Asn Asp Trp Asn Glu Phe Ser Lys Arg 
            500                 505                 510         


Ser Asp Ser Gln Lys Glu Ser Ala Tyr Lys Pro Asn Ala Leu Ala Tyr 
        515                 520                 525             


Leu Arg Met Arg Lys Lys Ile Val Asp Glu Val Leu Ala Pro Tyr Asn 
    530                 535                 540                 


Leu Asn His Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp Leu Cys 
545                 550                 555                 560 


Ile Val Asp Ile Asn Ala Asp Arg Ala Ile Ser Asp Arg Ile Lys Arg 
                565                 570                 575     


Met Lys Arg Glu Gly Met Asp Arg Leu Lys Ala Tyr Gln Lys Phe Thr 
            580                 585                 590         


Lys Thr Gly Lys Gly Lys Ile Pro Lys Ile Gly Glu Met Ala Thr Phe 
        595                 600                 605             


Leu Ala Lys Asp Ile Val Asp Met Val Ile Ser Thr Asp Lys Lys Lys 
    610                 615                 620                 


Lys Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu 
625                 630                 635                 640 


Phe Ala Asp Pro Glu Lys Lys Ser Leu Phe Val Asp Leu Ile Ser Lys 
                645                 650                 655     


Glu Leu His Leu Asn Glu Ala Asp Gly His Pro Phe Leu Lys Asn Ile 
            660                 665                 670         


Glu Phe Ser Lys Ile Arg Tyr Thr Gln Asp Leu Tyr Leu Ile Tyr Leu 
        675                 680                 685             


Gln Glu Lys Val Asn Lys Met Ile Asp Val Lys Asn Phe Arg Ser Gly 
    690                 695                 700                 


Lys Thr Ser Thr Ile Asp Lys Ser Trp Met Met Cys Thr Phe Tyr Lys 
705                 710                 715                 720 


Arg Glu Trp Asn Gln Glu Ala Gly Lys Gln Leu Thr Glu Val Lys Leu 
                725                 730                 735     


Pro Asp Asn Leu Ser Ser Ile Pro Phe Thr Leu Arg Gln Leu Lys Glu 
            740                 745                 750         


Lys Ile Ser Ser Asn Leu Asp Glu Trp Leu His Asn Leu Thr Lys Gly 
        755                 760                 765             


Asn Glu Ala Asn Asp Gly Lys Thr Pro Ile Asn Leu Pro Thr Asn Leu 
    770                 775                 780                 


Phe Asp Glu Pro Leu Ile Arg Leu Leu Gln Asn Asp Leu Asp Ala Gln 
785                 790                 795                 800 


Gln Val Glu Tyr Ser Ala Asp Ala Lys Tyr Asn Glu Leu Phe Lys Ile 
                805                 810                 815     


Trp Trp Arg Asn Arg Gly Asp Ser Thr Gln Ser Phe Tyr His Ala Glu 
            820                 825                 830         


Arg Glu Tyr Phe Ile Phe Asp Glu Lys Val Asn Phe Lys Leu Gln Glu 
        835                 840                 845             


Asn Ala Met Phe Ala Asp Phe Tyr Ser Leu Ser Val Lys Lys Ala Phe 
    850                 855                 860                 


Arg Ala Lys Gln Asn Ala Arg Arg Ile Glu Gln Lys Thr Asn Arg Arg 
865                 870                 875                 880 


Leu Pro Asp Ile Gln Phe Ser Gln Val Glu Lys Val Phe Lys Arg Ser 
                885                 890                 895     


Ile Ser Asn Thr Glu Lys Gln Ile Arg Leu Leu Gln Glu Glu Asp Gln 
            900                 905                 910         


Ile Leu Leu Leu Met Leu Glu Lys Leu Ile Ser Ser Asp Gln Asp Leu 
        915                 920                 925             


Asn Leu Lys Leu Asn Gln Ile Asp Ile Leu Leu Asn Glu Thr Ile Thr 
    930                 935                 940                 


Val Lys Glu Pro Val Arg Gly Asn Leu Phe Phe Asp Asn Asn Ala Glu 
945                 950                 955                 960 


Ile Thr Arg Arg Ile Ile Asp Gln Arg Lys Arg Lys Asp His Ser Met 
                965                 970                 975     


Leu His Lys Tyr Val Phe Asp Arg Arg Leu Pro Glu Leu Phe Glu Tyr 
            980                 985                 990         


Phe Ala Glu Asn Glu Ile Pro Leu  Gln Asp Leu Lys Asn  Glu Leu Glu 
        995                 1000                 1005             


Ala Tyr  Asn Asn Ala Lys Gln  Met Val Leu Ala Thr  Val Phe Lys 
    1010                 1015                 1020             


Phe Glu  Glu Ala Leu Val Ala  Asn Asn His Ala Asp  Asp Phe Met 
    1025                 1030                 1035             


Asp Ala  Asp Ser Lys Thr Gly  His Ile Pro His Lys  Ala Tyr Leu 
    1040                 1045                 1050             


Gln Trp  Leu Lys Lys Glu Gly  Met Ile Asn Glu Asn  Glu Phe Gln 
    1055                 1060                 1065             


Phe Leu  Asn Arg Val Arg Asn  Cys Phe Ser His Asn  Gln Phe Pro 
    1070                 1075                 1080             


Pro Lys  Asn Thr Met Ser Leu  Phe Val Ser Gln Trp  Ala Asp Gly 
    1085                 1090                 1095             


Asn Phe  Ala Leu Gln Ile Ala  Glu Leu Tyr Asn Glu  Lys Ile Asp 
    1100                 1105                 1110             


Ala Ile  Leu Ala Ile 
    1115             


<210>  2038
<211>  1081
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2038

Met Gln Ala Gln Ser Leu Phe Asp Glu Tyr Lys His Leu Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Val Met Ser Ile Met Asn Ile Ile Thr Val Leu Asn His Ile 
            20                  25                  30          


His Gln Ile Ala Gly Leu Lys Arg Asn Glu Leu Gly Asp Asp Asp Asn 
        35                  40                  45              


Ile Tyr Ser His Pro Val Leu Lys Tyr Ile Ala Pro Glu Asn Asn Ser 
    50                  55                  60                  


Thr Thr Leu Pro Glu Lys Arg Asp Leu Ile Lys Glu Leu Leu Leu Glu 
65                  70                  75                  80  


Tyr Leu Pro Phe Leu Glu Ala Met Lys Asp Cys Tyr Lys Glu Val Lys 
                85                  90                  95      


Val Glu Lys Asp Lys Arg Asn Asn Lys Tyr Val Lys Asp Lys Lys Gln 
            100                 105                 110         


Val Phe Ile Arg Asn Tyr Ser Asp Ile Tyr Cys Ile Tyr Trp Thr Leu 
        115                 120                 125             


Tyr Asn Ile Phe Ser Thr Leu Ile Asn Tyr Arg Asp Lys Ser Cys His 
    130                 135                 140                 


Tyr Arg Phe Ile Pro Ser Lys Asp Gln Glu Glu Tyr Ser Lys Arg Thr 
145                 150                 155                 160 


Glu Tyr Asp Thr Val Arg Ile Ile Asn Lys Tyr Tyr Thr Tyr Ala Leu 
                165                 170                 175     


Arg Lys Thr Lys Glu Lys Tyr Gly Tyr Thr Thr Glu Gln Leu Ser Phe 
            180                 185                 190         


Ile Gln Asn Asn Arg Tyr Thr Asp Asp Lys Lys Val Asn Phe Asn Phe 
        195                 200                 205             


Phe Leu Ser Met Gln Ser Ser Asn Asn Asn Leu Ser His Val Gly Val 
    210                 215                 220                 


Ala Gln Leu Ile Cys Leu Phe Leu Gln Lys Lys Asp Val Asp Asn Phe 
225                 230                 235                 240 


Leu Glu Asn Leu Pro Ile Tyr Asp Asn Arg Tyr Cys Leu Gly Ile Asp 
                245                 250                 255     


Glu His Met Ile Ile Lys Arg Ser Leu Ala Leu His Ser Ile Lys Leu 
            260                 265                 270         


Pro Lys Glu Arg Leu Asn Ser Glu Lys Lys Asp Met Ala Ile Ala Met 
        275                 280                 285             


Asp Met Leu Asn Glu Leu Lys Arg Cys Pro Lys Glu Leu Phe Asn Thr 
    290                 295                 300                 


Leu Pro Phe Asp Lys Gln Glu Arg Phe Arg Ile Ile Ser Ser Asp His 
305                 310                 315                 320 


Lys Glu Val Leu Leu Met Arg Ser Thr Asp Arg Phe Val Pro Leu Ile 
                325                 330                 335     


Leu Gln Tyr Ile Asp Cys Asn Lys Lys Phe Lys Asp Ile Arg Phe His 
            340                 345                 350         


Val Asn Met Gly Lys Leu Arg Tyr Leu Phe Ser Pro Asn Lys Leu Cys 
        355                 360                 365             


Ile Asp Asn Gln Glu Arg Val Arg Met Leu Glu His Leu Leu Asn Gly 
    370                 375                 380                 


Tyr Gly Arg Ile Asp Glu Val Glu Tyr Leu Arg Lys Ala Pro Asn Gly 
385                 390                 395                 400 


Thr Phe Gly Asn Thr Asn Ile Pro Ile Lys Gly Phe Gly Glu Ile Glu 
                405                 410                 415     


Arg Asp Ser Ala Asp Ser Asn Asn Tyr Pro Tyr Ile Val Asp Thr His 
            420                 425                 430         


Thr His Tyr Ile Leu Asn Asn Asn Lys Val Glu Phe Cys Phe Cys Glu 
        435                 440                 445             


Asp Ser Lys Asn Lys Asn Val Phe Pro Thr Ile Glu Lys Glu Ile Asn 
    450                 455                 460                 


Gly Lys Trp Tyr Val Glu Lys Thr Ala Pro His Cys Arg Ile Ser Phe 
465                 470                 475                 480 


Phe Glu Ile Pro Ala Met Ala Phe His Met Phe Leu Cys Gly Ser Glu 
                485                 490                 495     


Lys Thr Glu Lys Leu Ile Lys Asp Val Tyr Asn Asn Tyr Ile Ser Leu 
            500                 505                 510         


Phe Asn Ala Leu Lys Asn Gly Ala Leu Thr Glu Glu Asn Tyr Lys Asp 
        515                 520                 525             


Phe Asn Ile Pro Glu Cys Asp Met Pro Lys Lys Ile Leu Asp Phe Leu 
    530                 535                 540                 


Lys Gly Lys Ala Glu Gly Lys Ser Ile Asp Gly Tyr Val Lys Asn Ile 
545                 550                 555                 560 


Leu Lys Lys Glu Leu Lys Asp Thr Arg Lys Arg Ile Glu Gln Ala Pro 
                565                 570                 575     


Ser Glu Lys Asp Gln Met Pro Ser Lys Arg Asn Lys Ile Gly Thr Lys 
            580                 585                 590         


Ser Tyr Lys Arg Val Leu Thr Gly Lys Leu Ala Asp Phe Leu Ala Lys 
        595                 600                 605             


Asp Ile Val Lys Tyr Gln Pro Thr Leu Cys Ala Gly Asp Asp Tyr Gly 
    610                 615                 620                 


Ile Asp Arg Met Thr Gly Met Asn Tyr Arg Ile Met Gln Ala Thr Ile 
625                 630                 635                 640 


Ala Thr Tyr Asn Asp Asp Asp Asp Phe Asp Thr Phe Tyr Asn Val Phe 
                645                 650                 655     


Lys Met Ala Gly Leu Val Asp Gly Asp Glu Arg Lys Asn His Pro Phe 
            660                 665                 670         


Leu Lys Lys Val Leu Leu Ser Lys Pro Gln Asn Thr Val Ala Phe Asn 
        675                 680                 685             


Ile Lys Tyr Leu Lys Glu Lys Glu Ile Tyr Leu Arg Asn Ile Glu Lys 
    690                 695                 700                 


Lys Asn Ile Ile Pro Pro Phe Val Asn Arg Glu Arg Asn Lys Trp Cys 
705                 710                 715                 720 


Glu Arg Asp Cys Glu Tyr Tyr Arg Ile Leu Gly Glu Asn Leu Leu Asp 
                725                 730                 735     


Leu Pro Ile Glu Leu Pro Arg Gln Met Phe Tyr Lys Asp Ile Arg Ala 
            740                 745                 750         


Gln Leu Glu Pro Leu Met Pro Glu Ile Asp Phe Ser Gln Thr Asn Thr 
        755                 760                 765             


Thr Tyr Leu Ile Ala Glu Tyr Leu Lys Arg Val Arg Gly Asp Asp Phe 
    770                 775                 780                 


Gln Glu Phe Tyr Ser Trp Glu Arg Asn Tyr Arg Tyr Ile Asp Phe Leu 
785                 790                 795                 800 


Lys Cys Ile Arg Asp Asp Asn Gly Arg Ile Cys Ala Gln Tyr Thr Thr 
                805                 810                 815     


Thr Glu Glu Arg Glu Ser Leu Trp Glu Asp Ser Lys Asn Arg Thr Ala 
            820                 825                 830         


Glu Tyr Lys Arg Ser Glu Glu Gln Lys Asn Glu Lys Lys Asp Lys Asn 
        835                 840                 845             


Phe Glu Asp Ser Leu Glu Glu Arg Ile Ser Ser Ser His Ile Lys Phe 
    850                 855                 860                 


Gln Asn Thr Glu Lys His Ile Arg Arg Tyr Lys Val Gln Asp Ala Leu 
865                 870                 875                 880 


Leu Phe Met Ile Ala Glu Lys Gln Phe Gly Lys Tyr Leu Asp Asp Ile 
                885                 890                 895     


Lys Ala Lys Asn Phe Lys Leu Lys Asp Ile Met Pro Asp Thr Asp Lys 
            900                 905                 910         


Gly Ile Leu Ser Glu Thr Met Pro Ile Asp Phe Thr Phe Thr Lys Lys 
        915                 920                 925             


Asn Ile Lys Tyr Asn Ile His Ala Lys Asn Leu Lys Phe Lys Glu Tyr 
    930                 935                 940                 


Gly Asp Leu Phe Ile Leu Ala Asn Asp Lys Arg Leu Glu Ser Leu Trp 
945                 950                 955                 960 


Lys Ile Leu Ala Thr Asp Thr Val Asn Lys Glu Glu Ile Ser Glu Glu 
                965                 970                 975     


Phe Ala Lys Tyr Asp Phe Cys Arg Pro Asp Ile Thr Lys Leu Val Leu 
            980                 985                 990         


Asp Phe Glu Lys Asp Val Leu Glu  Lys Tyr Pro Glu Ile  Ile Glu Glu 
        995                 1000                 1005             


Ala Glu  Lys Glu Tyr Lys Lys  Phe Asp Phe Lys Phe  Ile Leu Asp 
    1010                 1015                 1020             


Trp Leu  Ile Asn Lys Lys Lys  Leu Asn Tyr Gly Ile  Arg Asn Lys 
    1025                 1030                 1035             


Leu Leu  Leu Ile Arg Asn Ala  Phe Asn His Asn Ser  Tyr Pro Asp 
    1040                 1045                 1050             


Lys Lys  Tyr Ala Glu Val Arg  Glu Leu Pro Glu Ile  Ala Thr Asn 
    1055                 1060                 1065             


Leu Lys  Lys Thr Phe Asp Glu  Asn Ala Lys Lys Tyr  Glu 
    1070                 1075                 1080     


<210>  2039
<211>  1112
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2039

Met Glu Asn Gln Glu Leu Lys Thr Arg Thr Met Lys Ser Glu Pro Tyr 
1               5                   10                  15      


Tyr Tyr Gly Ala Phe Leu Asn Met Ala Arg Leu Asn Ile Phe Asn Ile 
            20                  25                  30          


Ser Asn His Leu Ser Asn Lys Leu Asn Ile Leu Pro Thr Leu Ser Ser 
        35                  40                  45              


Glu Glu His Ile Ala Asn Ala Phe Phe Thr Asp Lys Asn Thr Lys Ile 
    50                  55                  60                  


Lys Trp Glu His Thr Tyr Asp Ile Leu Arg Arg Phe Ile Pro Ile Val 
65                  70                  75                  80  


Lys Val Phe Asp Thr Glu Ser Leu Pro Lys Gly Glu Val Gly Asn Asn 
                85                  90                  95      


Thr Gly Lys Asp Phe Ser Lys Met Ser Asp Thr Leu Lys Ile Ile Phe 
            100                 105                 110         


Lys Glu Leu Asn Glu Phe Arg Asn Asp Tyr Ser His Tyr Tyr Ser Thr 
        115                 120                 125             


Glu Lys Glu Asp Lys Arg Lys Ile Thr Ile Ser Asp Glu Leu Ala Asn 
    130                 135                 140                 


Phe Leu Asn Glu Asn Phe Lys Arg Ala Ile Ala Tyr Thr Lys Lys Arg 
145                 150                 155                 160 


Phe Lys Gly Val Phe Thr Glu Lys Asp Phe Glu Leu Ala Asn Asn Ile 
                165                 170                 175     


Gln Leu Phe Asn Lys Asp Lys Glu Ile Thr Glu Lys Gly Leu Ala Phe 
            180                 185                 190         


Leu Thr Ser Ile Phe Leu Glu Arg Glu Tyr Ala Phe Gln Phe Ile Ser 
        195                 200                 205             


Lys Ile Glu Gly Leu Lys Gly Thr Gln Lys Ser Glu Tyr Arg Ala Thr 
    210                 215                 220                 


Arg Glu Val Phe Met Ala Tyr Cys Val Asn Leu Pro His Asp Lys Phe 
225                 230                 235                 240 


Ile Ser Glu Asp Ala Lys Gln Ser Phe Ser Leu Asp Ile Ile Ser Glu 
                245                 250                 255     


Leu Asn Arg Cys Pro Gln Thr Leu Phe Asn Val Ile Thr Glu Lys Glu 
            260                 265                 270         


Gln Glu Lys Phe Arg Pro Thr Ile Asn Gln Gln Glu Lys Asn Asn Ile 
        275                 280                 285             


Ile Asn Asn Ser Val Pro Tyr Asp Ile Glu Asp Tyr Glu Glu Tyr Val 
    290                 295                 300                 


Asn Ser Ile Thr Lys Lys Ile Arg Tyr Asp Asn Arg Phe Pro Phe Phe 
305                 310                 315                 320 


Ala Leu Lys Phe Ile Asp Glu Thr Gln Val Phe Glu Lys Ile Arg Phe 
                325                 330                 335     


Gln Ile Asp Leu Gly Glu Ile Leu Leu Asp Glu Tyr Thr Lys Gln Leu 
            340                 345                 350         


Ala Asn Asn Glu Glu Lys Arg Gln Val Val Gln Asn Ala Lys Ala Phe 
        355                 360                 365             


Gly Arg Leu Asn Asp Phe Ile Asp Glu Asn Asn Val Leu Glu Asn Ile 
    370                 375                 380                 


Asn Lys Gln Asn Gly Ser Ala Ser Phe Ile Gln Tyr Ala Pro Asn Tyr 
385                 390                 395                 400 


Asn Phe Asp Asn Asn Lys Ile Gly Ile Asp Thr Thr Gly Lys Arg Ile 
                405                 410                 415     


Met Pro Ile Leu Thr Lys Gln Thr Asp Asn Asn Lys Lys Val Lys Asn 
            420                 425                 430         


Lys Leu Lys Gln Pro Leu Pro Lys Ala Phe Leu Ser Ile His Glu Leu 
        435                 440                 445             


Pro Lys Ile Ile Leu Leu Glu Tyr Leu Glu Lys Gly Lys Ala Glu Lys 
    450                 455                 460                 


Leu Ile Asn Asp Phe Leu Leu Ile Asn Glu Ser Gln Leu Leu Asn Tyr 
465                 470                 475                 480 


Lys Tyr Ile Glu Glu Ile Lys Asn Lys Leu Asn Asn Phe Asp Val Phe 
                485                 490                 495     


Gln Lys Arg Ser Gln Arg Lys Lys Leu Gln Thr Ala Tyr Asn Lys Thr 
            500                 505                 510         


Asn Ile Glu Glu Leu Gln Ser Arg Lys Glu Glu Leu Asn Lys Ile Leu 
        515                 520                 525             


Lys Glu Tyr Lys Leu Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Glu 
    530                 535                 540                 


Tyr Trp Leu Asn Ile Glu Asp Val Thr Pro Asn Glu Ala Ile Ser Asp 
545                 550                 555                 560 


Arg Ile Lys Leu Met Lys Arg Asp Cys Val Asp Arg Leu Arg Asp Ile 
                565                 570                 575     


Lys Lys Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala 
            580                 585                 590         


Lys Asp Ile Val Asp Met Ile Ile Ser Lys Asp Ile Lys Gln Lys Ile 
        595                 600                 605             


Ser Ser Phe Tyr Tyr Asp Lys Ile Gln Glu Cys Leu Ala Leu Tyr Asn 
    610                 615                 620                 


Val Ser Glu Lys Arg Asp Leu Phe Leu Thr Ile Cys Asn Glu Leu Arg 
625                 630                 635                 640 


Leu Leu Asp Ala Asp Lys Gly His Pro Phe Leu Lys Asn Ile Asn Leu 
                645                 650                 655     


Asn Arg Ile Asn Tyr Thr Ser Asp Phe Tyr Val Lys Tyr Leu Gln Glu 
            660                 665                 670         


Lys Gly His Lys Leu Ile Lys Glu Thr Asn Tyr Arg Thr Gly Lys Leu 
        675                 680                 685             


Val Glu Lys Asp Lys Ser Trp Met Phe Leu Asn Phe Tyr Tyr Leu Lys 
    690                 695                 700                 


Lys Asn Glu Thr Leu Asn Lys Met Met Thr Ile Val Gln Leu Pro Asp 
705                 710                 715                 720 


Asp Lys Ser Lys Leu Pro Phe Thr Ile Ala Gln Leu Asp Lys Pro Lys 
                725                 730                 735     


Asn Thr Phe Glu Glu Trp Ile Asn Asn Ile Thr Lys Gly Lys Thr Lys 
            740                 745                 750         


Thr Asp Lys Glu Lys Pro Ile Asp Leu Pro Thr Asn Ile Phe Asp Lys 
        755                 760                 765             


Glu Ile Glu Glu Ile Leu Lys Asn Lys Leu Ser Glu Glu Lys Ile Ala 
    770                 775                 780                 


Phe Thr Glu Asn Ala Asn Tyr Asn Gln Leu Phe Lys Leu Trp Trp Thr 
785                 790                 795                 800 


Asp Cys Arg Lys Asp Asn Val Gln Lys Phe Tyr Asp Ala Glu Arg Glu 
                805                 810                 815     


Tyr Val Ile Tyr Asp Glu His Val Lys Phe Ile Pro Asn Thr Lys Pro 
            820                 825                 830         


Lys Phe Glu Asn Tyr Tyr Asn Glu Ser Phe Pro Ile Val Leu Thr Arg 
        835                 840                 845             


Leu Lys Arg Asp Arg Glu Glu Ala Arg Lys Leu Asn Arg Lys Leu Pro 
    850                 855                 860                 


Pro Ile Glu Lys Ser Gln Val Glu Lys Val Phe Lys Gln Ala Ile Gly 
865                 870                 875                 880 


Ser Thr Glu Lys Glu Ile Arg Leu Leu Gln Glu Glu Asp Arg Ile Met 
                885                 890                 895     


Leu Leu Met Phe Glu Gln Leu Leu Glu Thr Asp Asn Asn Leu Asn Leu 
            900                 905                 910         


Lys Leu Asn Asn Ala Glu Ser Leu Leu Asn Glu Gln Ile Thr Ile Lys 
        915                 920                 925             


Glu Lys Ile Ser Leu Lys Leu Ser Phe Asn Glu Gln Glu Asp Lys Lys 
    930                 935                 940                 


Glu Ile Ile Lys Thr Ile Ile Asp Lys Arg Lys Arg Lys Asp Phe Ser 
945                 950                 955                 960 


Ile Leu Arg Lys Phe Lys Tyr Asp Lys Arg Leu Pro Glu Leu Cys Glu 
                965                 970                 975     


Tyr Phe Glu Thr Asp Asp Ile Ser His Ser Asp Leu Lys Lys Glu Leu 
            980                 985                 990         


Asp Glu Tyr Asn Lys Ala Lys Glu  Gln Ile Leu Ala Asn  Ala Phe Met 
        995                 1000                 1005             


Leu Glu  Lys Thr Ile Ile Glu  Lys Asp Lys Asp Gly  Ile Lys Ala 
    1010                 1015                 1020             


Leu Phe  Leu Asn Asp Asn Gly  Glu Lys Lys Tyr Gly  Asn Val Gln 
    1025                 1030                 1035             


His Lys  Pro Tyr Leu Thr Trp  Leu Lys Asn Lys Gly  Leu Ile Asn 
    1040                 1045                 1050             


Asp Asn  Glu Tyr Leu Phe Ile  Asn Met Val Arg Asn  Thr Phe Ser 
    1055                 1060                 1065             


His Asn  Gln Phe Pro Gln Lys  Arg Thr Ile Gln Ile  Phe Ile Asp 
    1070                 1075                 1080             


Lys Asn  Arg Gly Asn Pro Ile  Thr Phe Ala Glu Thr  Ile Lys Asn 
    1085                 1090                 1095             


Ala Tyr  Asn Lys Lys Ile Glu  Glu Ile Ile Val Lys  Ile Lys 
    1100                 1105                 1110         


<210>  2040
<211>  1131
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2040

Met Asn Asp Lys Ile Ala Gln Ser Tyr Ala Arg Trp Asn Phe Cys Gln 
1               5                   10                  15      


Tyr Phe Glu Asn Lys Ala Phe Val Ala Pro Ile Ala Glu Lys Ser Ala 
            20                  25                  30          


His Asn Ile Lys Arg Gln Asn Ser Ile Gly Lys Thr Thr Gly Gln Arg 
        35                  40                  45              


Leu Tyr Tyr Phe Ala Ile Gly His Lys Trp Lys Asn Leu Pro Asn Val 
    50                  55                  60                  


Ile Phe Gln Arg Phe Tyr Asp Glu Gln Gln Lys Gln Tyr Ala Thr Gly 
65                  70                  75                  80  


Asp Tyr Met Ala Leu Gln Lys Glu Ala Phe Pro Lys Lys Asp Ile Glu 
                85                  90                  95      


Glu Leu Leu Arg Asn Leu Arg Asn Leu Asn Asn His Tyr Val His Asp 
            100                 105                 110         


Phe Gln Lys Leu Ile Ile Asp Lys Glu Asn Asn Asn Ala Leu Arg Lys 
        115                 120                 125             


Phe Leu Lys Glu Ser Phe Arg Met Ala Ala Thr Met Val Tyr Phe Glu 
    130                 135                 140                 


His Glu Asn Ile Trp Glu Arg Leu Cys Glu Lys Thr Asn Gln Lys Leu 
145                 150                 155                 160 


Ser Asn Thr Ser Phe Thr Ser Glu Gln Tyr Asp Lys Lys Leu Gln Glu 
                165                 170                 175     


Leu Tyr Gln Lys His Ile Thr Asn Lys Asp Phe Lys Asn Lys Leu Cys 
            180                 185                 190         


Glu Phe Leu Ser Lys Lys Phe Leu Phe Asn Lys Thr Asn Asn Asp His 
        195                 200                 205             


Thr Leu Asn Asp Leu Asp Ser Leu Ile Glu Tyr Leu Leu Phe Val Arg 
    210                 215                 220                 


Val Ser Ser Asp Phe Glu Trp Lys Ile Asn Asn Glu His Ala Val Phe 
225                 230                 235                 240 


Thr Ile Gln Lys Gly Glu Tyr Leu Ser Phe Val Gly Ala Leu Phe Ala 
                245                 250                 255     


Leu Cys Met Phe Leu Tyr Lys Asp Glu Ala Asn Thr Met Ile Ser Lys 
            260                 265                 270         


Val Lys Gly Tyr Lys Lys Thr Lys Glu Lys Glu Met Met Ala Lys Arg 
        275                 280                 285             


Asp Ile Met Thr Phe Phe Ser Lys Asn Ile Ser Ala Gln Asp Ile Asp 
    290                 295                 300                 


Cys Glu Glu Lys Asn Leu Ile Tyr Phe Arg Asp Ile Ile Leu Tyr Leu 
305                 310                 315                 320 


Asn Lys Tyr Pro Leu Glu Trp Asn Lys Ala Leu Glu Lys Glu Val Asn 
                325                 330                 335     


Ala Asp Lys Val Phe Glu Val Leu Lys Lys Glu Ile Ala Glu Met Glu 
            340                 345                 350         


Glu Asn Arg Ile Leu Asp Val Cys Leu Thr Pro Tyr Pro Gln Arg Thr 
        355                 360                 365             


Ile Gln Ser Phe Ile Leu Ser Asp Asn Phe Asp Lys Ile Pro Asp Val 
    370                 375                 380                 


Asn Lys Lys Met Ile Asp Glu Gln Val Glu Ala Ile Gln Lys Asp Val 
385                 390                 395                 400 


Glu Lys Leu Ala Gln Arg Leu Lys Glu Asn Thr Phe Phe Thr Ser Tyr 
                405                 410                 415     


Gly Arg Asn Gln Asp Arg Phe Met Glu Phe Ala Leu Arg Tyr Leu Ala 
            420                 425                 430         


Glu Arg Asn Tyr Phe Gly Ser Asp Ala Gln Phe Lys Cys Tyr Arg Phe 
        435                 440                 445             


Tyr Thr Thr Glu Glu Gln Asn Val Phe Leu Glu Ser Glu Lys Glu Arg 
    450                 455                 460                 


Leu Pro Lys Lys Glu Phe Asp Lys Ile Lys Phe His Arg Gly Arg Val 
465                 470                 475                 480 


Val Tyr Phe Ser Thr Leu Ala Asp His Arg Asp Arg Tyr Pro Asp Trp 
                485                 490                 495     


Asp Thr Pro Phe Val Phe Glu Asn Asn Ala Ile Gln Ile Arg Ile Thr 
            500                 505                 510         


Leu Asn Asp Lys Thr Val Leu Leu Ser Ile Gln Arg Pro Leu Leu Val 
        515                 520                 525             


Cys Leu Val Gln His Cys Leu Met Gln Lys Thr Pro Glu Gly Lys Gly 
    530                 535                 540                 


Lys Asn Leu Leu Glu Asp Tyr Tyr Ala His Tyr Arg Glu Asn Leu Ala 
545                 550                 555                 560 


Thr Ala Leu Thr Ala Phe Gly Lys Ser Lys Thr Glu Val Ser Ser Glu 
                565                 570                 575     


Asp Lys Asn Ile Ile Glu Gln Leu Phe Pro Arg Arg Ala Val Lys Arg 
            580                 585                 590         


Trp Ala Thr Gly Glu Glu Val Gln Leu Thr Asn Glu Gly Leu Asp Arg 
        595                 600                 605             


Ile Leu Lys Glu Ala Lys His Cys Glu Leu Arg Tyr Gln Lys Lys Leu 
    610                 615                 620                 


Glu Glu Val Glu Lys Thr Val Glu Arg Thr Gly Asn Pro Asp Pro Leu 
625                 630                 635                 640 


Thr His Phe Leu Lys Lys Asn Lys Gly Lys Gln Phe Lys Leu Arg Phe 
                645                 650                 655     


Val Lys Lys Ala Trp Asn Leu Met Tyr Phe Lys Pro Val Tyr Lys Glu 
            660                 665                 670         


Arg Tyr Glu Glu Lys Lys Glu His His Lys Ser Tyr His Leu Thr Arg 
        675                 680                 685             


Glu Glu Tyr Asn Asp Phe Cys Cys Tyr Met Phe Asp Tyr Gly Val Asn 
    690                 695                 700                 


Ser Asp Tyr Gln Arg Leu Leu Arg Glu Leu Leu Asp Ser Lys Gly Phe 
705                 710                 715                 720 


Leu Ala Asn Pro Glu Leu Ala Gly Leu Phe Glu Lys Cys Lys Ser Leu 
                725                 730                 735     


Asp Asp Phe Tyr Gln Asp Thr Lys Lys Ile Phe Glu Thr Trp Ile Ser 
            740                 745                 750         


Thr Ser Val Arg Glu Lys Arg Glu Asp Arg Phe Gln Leu Ser Met Tyr 
        755                 760                 765             


Lys Asn Phe Ser Phe Asn Gln Glu Val Pro Gln Pro Ile Leu Tyr Ile 
    770                 775                 780                 


Asn Leu Gln His Phe Leu Asn His Val Lys Lys Asp Lys Gly Glu Gln 
785                 790                 795                 800 


Glu Tyr Ala Tyr Pro Leu Pro Pro Asn Gln Ser Tyr Leu Ile Ser Ser 
                805                 810                 815     


Tyr Tyr Phe Lys Asp His Gln Lys Ser Asn Asn Ser Thr Leu Asn Lys 
            820                 825                 830         


Leu His Phe Lys Leu Arg Asn Thr Cys Val Glu Asp Cys Leu Leu Tyr 
        835                 840                 845             


Glu Ile Ala Met Tyr Tyr Phe Asn Lys Glu Asn Pro Ile Thr Asp Pro 
    850                 855                 860                 


Ala Arg Asn Lys Val Asn Lys Ile Leu Gln Ser Lys Asp Leu Phe Ile 
865                 870                 875                 880 


Glu Ile Gln Asp Lys Arg Glu Leu Ser Lys Thr Phe Arg Leu Tyr Phe 
                885                 890                 895     


Pro Phe Lys Gln Ile Glu Lys Val Gly Ser Met Leu His Asn Asp Gln 
            900                 905                 910         


Glu Lys Glu Arg Leu Thr Asp Val Pro Arg Tyr Ile Asp Leu Leu Ala 
        915                 920                 925             


Asp Arg Glu Glu Arg Lys Lys Asn Lys Gln Trp Asn Lys Glu Ile Arg 
    930                 935                 940                 


Lys Ile Tyr Asp Asn Tyr Lys Ser Gly Lys Ile Leu Leu Glu Asp Tyr 
945                 950                 955                 960 


Thr Tyr Leu Gln Lys Glu Val Val Arg Glu Ser Gly Thr Phe Leu Ser 
                965                 970                 975     


Val Tyr Met Glu Met Glu Lys Phe Phe Ile Leu Gln Glu Lys Leu Arg 
            980                 985                 990         


Pro Lys Pro Gly Arg Asn Asn Ile  Val Tyr Lys Lys Ile  Thr Pro Leu 
        995                 1000                 1005             


Lys Thr  Leu Leu Glu Glu Ile  Glu Gln Glu Gln Lys  Ile Glu Lys 
    1010                 1015                 1020             


Phe Asp  Asn Asn Gly Asn Arg  Gln Ser Asn Ile Ile  Arg Asn Asp 
    1025                 1030                 1035             


Ala Cys  His Phe Ser Phe Pro  Gln Lys Leu Tyr Asp  Thr Ile Leu 
    1040                 1045                 1050             


Ile Glu  Leu Glu Lys Lys Phe  Ile Lys Lys Tyr Val  Ser Ser Pro 
    1055                 1060                 1065             


Thr Pro  Leu Ser Phe Gln Asp  Phe Pro Ala Pro Ile  Arg Lys Val 
    1070                 1075                 1080             


Leu Asp  Tyr Phe Leu Glu Ser  Val His Asn Ser Leu  Phe Gln Tyr 
    1085                 1090                 1095             


Lys Ile  Lys Asn Lys Glu Glu  Arg Ile Ala Thr Ala  Gln Arg Glu 
    1100                 1105                 1110             


Tyr Ile  Asn Gln Val Ile Lys  Lys Tyr Ile Gln Pro  Leu Gln Arg 
    1115                 1120                 1125             


Arg Ile  His 
    1130     


<210>  2041
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2041

Met Glu Thr Lys Gln Gln Val Gly Lys Gly Ile Ser Tyr Asp His Arg 
1               5                   10                  15      


Arg Pro Asp Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asp Gly Val Ile Gln Glu Phe Ala Met Arg Leu Asn Arg 
        35                  40                  45              


Glu Tyr Asp Pro Glu Asn Lys Asn Gln Ser Leu Phe Ser Tyr Phe Asn 
    50                  55                  60                  


Ile Asn Ala Ser Phe Thr Asp Trp Glu Arg Gly Val Asn Ile Leu Lys 
65                  70                  75                  80  


Glu Tyr Trp Pro Met Met Glu Phe Ile Asp Arg Pro Ala Thr Asp Lys 
                85                  90                  95      


Gln Phe Glu Ala Glu Lys Pro Glu Asn Arg Glu Ala Ala Lys Arg Lys 
            100                 105                 110         


Tyr Phe Leu Ala Thr Leu Gly Ala Leu Leu Thr Ser Ile Lys Asp Leu 
        115                 120                 125             


Arg His Tyr Tyr Thr His Tyr Tyr His Pro Pro Val His Leu Asn Asp 
    130                 135                 140                 


Asp Leu Phe Leu Phe Leu Asp His Ala Leu Leu Tyr Thr Ala Phe Asp 
145                 150                 155                 160 


Val Lys Lys Ala Lys Met Lys Asp Asp Lys Thr Arg Gln Leu Leu Asn 
                165                 170                 175     


Gln Asn Leu Ser Leu Glu Leu Glu Lys Leu Lys Lys Leu Lys Val Glu 
            180                 185                 190         


Glu Leu Lys Lys Lys Lys Glu Lys Gly Ile Lys Val Asn Leu Gln Asp 
        195                 200                 205             


Glu Lys Gly Ile Leu Asn Ala Ile Tyr Asn Asp Ala Phe Ala His Ile 
    210                 215                 220                 


Ile Thr Lys Glu Lys Asp Ser Asp Lys Asp Lys Leu Glu Thr Arg Tyr 
225                 230                 235                 240 


Lys Ser Ile Leu Pro Gln Asp Glu Ala Ala Glu Thr Gly Ile Asn Ile 
                245                 250                 255     


Ser Ile Ser Gly Leu Ile Phe Leu Leu Ser Leu Phe Leu Ser Arg Lys 
            260                 265                 270         


Glu Ile Glu Gln Leu Lys Ser Asn Ile Glu Gly Tyr Lys Gly Lys Val 
        275                 280                 285             


Leu Asn Ile Glu Thr Glu Val Asp Arg Lys His Asn Ser Leu Lys Tyr 
    290                 295                 300                 


Met Ala Thr His Trp Val Phe Ser Ile Leu Ala Phe Lys Gly Leu Lys 
305                 310                 315                 320 


Gln Arg Leu Thr Asn Ser Phe Glu Lys Glu Ser Leu Leu Ile Gln Met 
                325                 330                 335     


Met Asp Glu Leu Asn Lys Val Pro Asp Glu Leu Tyr Gln Thr Leu Ser 
            340                 345                 350         


Glu Thr Ala Lys Lys Glu Phe Leu Glu Asp Ile Asn Glu Tyr Val Ser 
        355                 360                 365             


Glu Gly Asp Asp Asn Glu Lys Ala Thr Tyr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Ser Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gln Phe Pro Thr Leu Lys Phe Gln Ile Phe Val Gly 
                405                 410                 415     


Gln Tyr Leu His Asp Asn Arg Pro Lys Thr Leu Ala Ser Asn Gly Met 
            420                 425                 430         


Thr Ala Gln Arg Met Ile Lys Glu Lys Ile Asn Leu Phe Gly Asn Leu 
        435                 440                 445             


Ser Glu Val Thr Lys His Lys Ser Asp Phe Phe Glu Lys Glu Ser Ala 
    450                 455                 460                 


Ala Gln Gly Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Trp Ala Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Val Tyr Ile Asp Met Ile Gly Lys Glu Gly Lys Ala 
                485                 490                 495     


Lys Glu Ile Gln Val Gln Ile Asn Lys Tyr Arg Lys Gln Leu Asn Pro 
            500                 505                 510         


Ala Pro Gln Arg Asp Lys Arg Ile Ser Lys Lys Glu Ile Ile Glu Gln 
        515                 520                 525             


Leu Tyr Lys Glu Lys Val Val Tyr Gly Asp Pro Thr Leu Met Leu Ser 
    530                 535                 540                 


Ala Asn Glu Leu Met Ala Leu Leu Tyr Glu Leu Ile Val Asn Gly Lys 
545                 550                 555                 560 


Ser Gly Ala Glu Leu Glu Asn Lys Ile Val Glu Gln Ile Ile Ala Arg 
                565                 570                 575     


Tyr Glu Gln Ile Glu Ala Tyr Asp Pro Thr Thr Gln Gln Leu Pro Thr 
            580                 585                 590         


Asn Gln Met Pro His Lys Leu Gln Lys Ser Arg Lys Asp Ser Lys Val 
        595                 600                 605             


Thr Asp Thr Asp Lys Leu Leu Lys Thr Ile Asp Lys Glu Ile Asp Glu 
    610                 615                 620                 


Gly Asn Lys Lys Leu Glu Leu Ile Ala Cys His Arg Lys Glu Trp Glu 
625                 630                 635                 640 


Glu Ala Glu Gln Arg Lys Lys Ser Gly Lys Arg Asn Asn Pro Gly Thr 
                645                 650                 655     


Lys Ser Arg Lys His Leu Phe Tyr Ala Ser Glu Met Gly Glu Glu Ala 
            660                 665                 670         


Thr Trp Ile Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Pro Ala Arg 
        675                 680                 685             


Ala Glu Trp Lys Gly Thr His His Ser Glu Leu Gln Arg Leu Leu Ala 
    690                 695                 700                 


Phe Tyr Ser Thr Gln Arg Leu Glu Ala Trp Gln Leu Val Glu Ser Val 
705                 710                 715                 720 


Trp Thr Ala Asn Thr His Ser Phe Trp Glu Glu Asn Phe Lys Glu Ala 
                725                 730                 735     


Phe Tyr Lys Pro Glu Phe Glu Asn Phe Tyr Gly Ala Tyr Ile Glu Ile 
            740                 745                 750         


Arg Thr Lys Ile Leu Thr Thr Cys Arg Ser Ile Leu Glu Asn Asn Pro 
        755                 760                 765             


Glu Ala Thr Met Asn Asn Asp Thr Glu Lys Glu Trp Asp Lys Val Phe 
    770                 775                 780                 


Thr Leu Phe Asp Lys Arg Leu Tyr Arg Thr Ser Thr Thr Asp Glu Gln 
785                 790                 795                 800 


Lys Lys Gln Leu Leu Thr Lys Pro Phe Ala Phe Pro Arg Gly Leu Phe 
                805                 810                 815     


Asp Asp Lys Pro Thr Phe Leu Pro Gly Ser Lys Pro Asn Glu Asn Pro 
            820                 825                 830         


Glu Arg Phe Ala Ala Trp Tyr Ser Tyr Gly Tyr Thr Tyr Ser Gly Lys 
        835                 840                 845             


Phe Gln Ser Phe Tyr Asp Met Pro Arg Asn Tyr Ser Asp Trp Tyr Lys 
    850                 855                 860                 


Lys Leu Lys Glu Asp Gly Lys Leu Pro Arg Leu Asp Lys Lys Thr Glu 
865                 870                 875                 880 


Gln Glu Lys Ile Leu Arg Phe Arg Met Asp Cys Asp Leu Asn Ile Lys 
                885                 890                 895     


His Ile Arg Phe Gln Asp Ile Tyr Val Lys Leu Met Val Asp Ser Leu 
            900                 905                 910         


Tyr Lys Ala Val Phe Gly Gln Gln Pro Glu Phe Asp Leu Ser His Leu 
        915                 920                 925             


Tyr Asp Thr Arg Ser Glu Arg Tyr Glu Asn Asn Thr Ile Ala Gln Arg 
    930                 935                 940                 


Gln Lys Ser Arg Gln Glu Gly Asp Asn Ser Asp Asn Ala Ile Asn Glu 
945                 950                 955                 960 


Asn Tyr Val Trp Asn Lys Thr Phe Ala Ile Ser Leu Tyr Asn Gly Arg 
                965                 970                 975     


Ile Thr Glu Ser Gln Val Lys Leu Lys Asp Val Gly Lys Phe Arg Arg 
            980                 985                 990         


Phe Ala Thr Asp Pro Arg Val Gln  Thr Leu Ile Ser Tyr  Asp Asp Thr 
        995                 1000                 1005             


Arg Thr  Trp Thr Lys Leu Glu  Ile Glu Asn Glu Leu  Asp Asn Lys 
    1010                 1015                 1020             


Ala Asp  Ala Tyr Glu Pro Ile  Arg Arg Thr Gln Ser  Leu Lys Ala 
    1025                 1030                 1035             


Ile Gln  Gln Leu Glu Lys Asn  Ile Leu Lys Lys Asn  Gly Phe Asn 
    1040                 1045                 1050             


Gly Lys  Gln His Pro Glu Glu  Leu Lys His Asn Gly  Asn Pro Asn 
    1055                 1060                 1065             


Phe Arg  Lys Tyr Ile Ala Asn  Gly Leu Leu Lys His  Arg Thr Asp 
    1070                 1075                 1080             


Ile Arg  Gln Glu Glu Leu Ala  Leu Ile Ser Asp Thr  Glu Phe Gln 
    1085                 1090                 1095             


Glu Ile  Gly Leu Glu Arg Ile  Arg Gln Thr Asn Pro  Leu Ile Gln 
    1100                 1105                 1110             


Lys Ala  Tyr Leu Leu Ile Leu  Leu Arg Asn Lys Phe  Gly His Asn 
    1115                 1120                 1125             


Gln Leu  Pro Asp Gln Glu His  Phe Arg Leu Met Arg  Ser Ile Tyr 
    1130                 1135                 1140             


Pro Tyr  Asn Gln Gln Glu Ser  Tyr Ser Ala Tyr Phe  Asn His Val 
    1145                 1150                 1155             


Ile Thr  Gln Ile Ile Glu Glu  Leu Asn Thr 
    1160                 1165             


<210>  2042
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2042

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Ala Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2043
<211>  1171
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2043

Met Glu Glu Ile Val Leu Lys Asn Asn Lys Ile Glu Phe Asp His Ser 
1               5                   10                  15      


Leu Leu Lys Asp Lys His Phe Phe Ala Gly Tyr Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asp Gln Ala Leu Glu Ala Tyr Lys Val Arg Phe Gly Val 
        35                  40                  45              


Lys Ala Asn Glu Lys Asp Asn Phe Ser Val Ile Asp Asn Leu Asp Ile 
    50                  55                  60                  


Lys Lys Leu Ser Glu Pro Asp Tyr Ile Asn Arg Ile Asp Phe Leu Lys 
65                  70                  75                  80  


Leu His Phe Pro Val Val Gly Tyr Leu Asp Leu Pro Val Thr Asn Asp 
                85                  90                  95      


Leu Phe Lys Asn Glu Ile Asp Lys Asn Leu Ala Arg Arg Leu Tyr Phe 
            100                 105                 110         


Lys Glu Lys Phe Lys Val Leu Val Lys Thr Ile Asp Ser Leu Arg Asn 
        115                 120                 125             


Phe Tyr Thr His Tyr Tyr His Lys Ser Leu Pro Phe Asp Lys Lys Leu 
    130                 135                 140                 


Phe Thr Leu Val Asp Glu Ile Phe Leu Gln Val Ile Leu Asp Val Lys 
145                 150                 155                 160 


Arg Leu Lys Lys Lys Asn Asp His Thr Arg Gln Phe Leu Lys Gln Ser 
                165                 170                 175     


Leu Lys Glu Glu Tyr Pro Ile Leu Phe Asn Leu Lys Lys Lys Asp Leu 
            180                 185                 190         


Gln Asp Lys Lys Ala Lys Gly Lys Lys Val Ser Leu Asp Thr Val Ser 
        195                 200                 205             


Ile Asn Asn Ala Val Phe Asn Asp Ala Phe Phe His Leu Leu Tyr Gln 
    210                 215                 220                 


Lys Asp Gln Leu Asn Pro Phe Tyr Lys Ser Ala Leu Leu Asp Gly Glu 
225                 230                 235                 240 


His Tyr Glu Asn Thr Ile Ser Ile Ser Gln Asn Gly Leu Leu Phe Leu 
                245                 250                 255     


Leu Gly Met Phe Leu Asn Lys Lys Glu Gly Glu Asp Leu Arg Ser Gln 
            260                 265                 270         


Ile Lys Gly Phe Lys Gly Lys Val Val Lys Asp His Pro Glu Phe Pro 
        275                 280                 285             


Asn Ala Lys Asn Asn Ser Phe Arg Phe Met Ala Thr His Trp Val Phe 
    290                 295                 300                 


Ser Tyr Leu Ala Phe Lys Gly Ile Arg Gln Lys Ile Ser Thr Ala Phe 
305                 310                 315                 320 


Asp Lys Glu Thr Leu Leu Ile Gln Ile Val Asp Glu Leu Ser Lys Val 
                325                 330                 335     


Pro Asp Glu Val Tyr Asn Asn Leu Ser Phe Glu Lys Gln Gln Gln Phe 
            340                 345                 350         


Val Glu Asp Ile Asn Glu Tyr Ile Lys Glu Gly Asn Glu Thr Lys Arg 
        355                 360                 365             


Leu Asn Asp Ala Ile Val Ile His Pro Val Ile Arg Lys Arg Tyr Glu 
    370                 375                 380                 


Asn Lys Phe Asn Tyr Phe Val Leu Arg Tyr Leu Asp Glu Phe Ala Gly 
385                 390                 395                 400 


Phe Pro Ser Leu Arg Phe Gln Ile His Leu Gly Asn Tyr Val His Asp 
                405                 410                 415     


Arg Arg Ile Lys Asn Ile Ala Gly Thr Ser Phe Glu Thr Asp Arg Ile 
            420                 425                 430         


Val Lys Glu Lys Ile Asn Val Phe Gly Asn Leu Ser Glu Val Gly Asn 
        435                 440                 445             


Leu Lys Ala Asp Tyr Phe Glu Lys Asn Glu Ala Ser Ala Thr Asp Ser 
    450                 455                 460                 


Gly Trp Glu Ile Phe Pro Asn Pro Ser Tyr Asn Phe Val Ser Glu Asn 
465                 470                 475                 480 


Ile Pro Ile Phe Ile Asn Leu Gln Lys Ser Lys Val Pro Gly Ala Ala 
                485                 490                 495     


Lys Leu Phe Gly Gln Ile Lys Ser Lys Gln Ile Lys Val Glu Lys Glu 
            500                 505                 510         


Asp Gly Asn Gln Arg Ala Glu Ser Lys Tyr Thr Lys Glu Gln Met Thr 
        515                 520                 525             


Thr Leu Ile Asp Pro Asn Ile Lys Gly Gln Thr Phe Glu Lys Ile Tyr 
    530                 535                 540                 


Ile Gly Pro Pro Thr Ala Met Leu Ser Leu Asn Glu Leu Pro Ala Leu 
545                 550                 555                 560 


Leu Tyr Glu Leu Leu Val Arg Lys Val Ser Pro Glu Ala Ile Glu Asn 
                565                 570                 575     


Thr Met Ile Gln Lys Leu Met Asp Arg Phe Ser Thr Ile Glu Lys Tyr 
            580                 585                 590         


Ala Pro Ser Asp Lys Leu Ser Ala Ser Gln Ile Thr Lys Asn Leu Arg 
        595                 600                 605             


Arg Ser Asp Val Thr Glu Lys Ile Asp Thr Glu Lys Leu Gln Arg Ser 
    610                 615                 620                 


Ile Glu Lys Glu Ile Lys Ile Cys Asp Glu Lys Leu Ala Thr Ile Ser 
625                 630                 635                 640 


Gln Asn Arg Lys Asp Thr Arg Val Pro Tyr His Lys Arg Lys Phe Ile 
                645                 650                 655     


Phe Thr Asn Lys Glu Leu Gly Ser Glu Ala Thr Trp Leu Thr Asp Asp 
            660                 665                 670         


Leu Ile Arg Phe Met Pro Lys Asp Ala Arg Glu Asn Trp Lys Gly Tyr 
        675                 680                 685             


Gln His Ser Gln Leu Gln Gln Ser Leu Ala Tyr Phe Asn Gln Asn Thr 
    690                 695                 700                 


Arg Glu Ala Phe Ser Leu Leu Gln Ser Val Trp Asp Phe Lys Asp Thr 
705                 710                 715                 720 


Asn Tyr Asn Trp Asn Ser Gly Ile Gln Lys Ala Phe Ile Ser Cys Lys 
                725                 730                 735     


His Phe Asp Met Leu Leu Glu Arg Tyr Leu Asn Asn Arg Lys Asp Thr 
            740                 745                 750         


Leu Thr Ala Met Tyr Glu Gly Val Arg Ser Phe Ser Ser Asn Thr Lys 
        755                 760                 765             


Met Leu Lys Lys Leu Ile Glu Gln Gln Asn Ile Trp Thr Val Phe Asn 
    770                 775                 780                 


Lys Arg Leu Phe Gln Ile Asn Pro Ile Asp Gln Gln Lys Glu Arg Leu 
785                 790                 795                 800 


Leu Ala Lys Pro Leu Val Phe Pro Arg Gly Ile Phe Asp Glu Lys Pro 
                805                 810                 815     


Thr Phe Ile Lys Asp Ser Lys Leu Thr Glu Gln Pro Glu Ala Phe Ala 
            820                 825                 830         


Asp Trp Tyr Arg Tyr Thr Tyr Lys Ala His Leu Tyr Gln Arg Phe Tyr 
        835                 840                 845             


Glu Leu Glu Arg Asn Cys Asp Leu Leu Phe Glu Gln Asn Gln Leu Ser 
    850                 855                 860                 


Asn Glu Tyr Phe Ser Ala Asn Lys Lys Asn Leu Ser Lys Ala Glu Gln 
865                 870                 875                 880 


Leu Glu Leu Phe Gln Leu Lys Gln Asp Leu Lys Ile Lys Lys Val Lys 
                885                 890                 895     


Asn Gln Asp Leu Phe Leu Lys Leu Ile Ala Glu Ala Ile Tyr Asn Lys 
            900                 905                 910         


Thr Phe Glu His Asp Ala Ser Leu Ser Leu Ser Asp Phe Tyr Leu Thr 
        915                 920                 925             


Gln Glu Glu Arg Leu Glu Lys Glu Ala Asn Ala Arg Arg Gln Ser Glu 
    930                 935                 940                 


Arg Gln Lys Asn Asp Thr Ser Glu Asn Ile Ile Lys Asp Asn Phe Ile 
945                 950                 955                 960 


Trp Ser Lys Thr Ile Ser Ile Lys Asp Gly Gln Val Tyr Ala Glu Ser 
                965                 970                 975     


Ile Lys Leu Lys Asp Ile Gly Lys Phe Arg Arg Phe Leu Asn Asp Ser 
            980                 985                 990         


Lys Val Lys Thr Ile Leu Ser Tyr  Asp Pro Asn Arg Arg  Trp Thr Lys 
        995                 1000                 1005             


Gln Glu  Leu Glu Asp Glu Leu  Ser Ile Lys Arg Asp  Ser Tyr Glu 
    1010                 1015                 1020             


Thr Ile  Arg Arg Glu Glu Leu  Ile Lys Glu Ile Gln  Leu Phe Glu 
    1025                 1030                 1035             


Lys Ser  Ile Leu Glu Ser Tyr  Asn Phe Asp Gly Gln  Gln His Pro 
    1040                 1045                 1050             


Thr Asp  Leu Glu Ser Glu Asn  Asn Pro Lys Phe Lys  His Tyr Val 
    1055                 1060                 1065             


Val Asn  Gly Val Leu Arg Lys  Arg Lys Leu Ala Pro  Glu Asp Glu 
    1070                 1075                 1080             


Ile Gln  Trp Leu Leu Asp Cys  Thr Glu Lys Gln Phe  Asp Lys Leu 
    1085                 1090                 1095             


Thr Leu  Ala Glu Leu Thr Thr  Lys Thr Asp Thr Ile  Gln Lys Ala 
    1100                 1105                 1110             


Phe Leu  Leu Ile Ile Ile Arg  Asn Lys Phe Ala His  Asn Gln Leu 
    1115                 1120                 1125             


Pro Lys  Asp Ile Phe Tyr Ser  Leu Ile Lys Lys His  Thr Tyr Pro 
    1130                 1135                 1140             


Asp Gly  Val Gly Val Ser Asn  Asp Lys Thr Ala Ser  Ser Val Ile 
    1145                 1150                 1155             


Leu Glu  Phe Thr Arg Ser Val  Ile Ala Met Phe Arg  Asp 
    1160                 1165                 1170     


<210>  2044
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2044

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Ala Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Leu Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2045
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2045

Met Asn Thr His Gln Glu Glu Leu Gln Ser Trp Ile Thr Arg Lys Arg 
1               5                   10                  15      


Leu Pro Asp Thr Glu Met Lys Lys Tyr Trp Ala Ala Tyr Met Asn Leu 
            20                  25                  30          


Ala Arg Leu Asn Phe Phe Lys Thr Leu Met Phe Ile Ser Asn Ser Ile 
        35                  40                  45              


Gly Asp Leu Lys Pro Ala Lys Asp Asn Asn Gly Lys Gly Asn Thr Glu 
    50                  55                  60                  


Val Asn Met His Asn Met Gly Ile Leu Thr Ala Leu Leu Gly Pro Glu 
65                  70                  75                  80  


Asp Glu Glu Lys Ala Arg Leu Leu Ile Phe Lys His Phe Pro Phe Leu 
                85                  90                  95      


Arg Thr Phe Cys Ile Glu Lys Glu Leu Ser Leu Ser Lys Gln Arg Thr 
            100                 105                 110         


Ile Leu Ile Asp Met Ala Cys Ile Ile Gly Arg Tyr Arg Asn Met Tyr 
        115                 120                 125             


Ser His Ser Ile Phe Ile Ser Asp Asp Asn Glu Lys Val Leu Glu Ser 
    130                 135                 140                 


Glu Lys Arg Cys Ser Glu Tyr Leu Gln Ser Ile Leu Thr Val Ser Thr 
145                 150                 155                 160 


Arg Ile Ile Lys Glu Arg Tyr Arg Ser Asn Lys Asn Asp Ala Gln Arg 
                165                 170                 175     


Gly Met Ile Asp Asp Lys Ser Leu Glu Phe Ile Ser Glu Asn Lys Val 
            180                 185                 190         


Lys Phe Val Tyr Asp Glu Asn Gly Lys Arg Ile Thr Ala Pro Asn Lys 
        195                 200                 205             


Lys Tyr Tyr Leu Ser Thr Ile Asp Lys Asp Asn Thr His Leu Ser Tyr 
    210                 215                 220                 


Phe Gly Lys Leu Met Leu Thr Cys Ile Leu Leu Glu Lys Lys Tyr Ala 
225                 230                 235                 240 


Thr Ala Phe Leu Thr Gln Cys His Phe Leu Asp Ala Phe Asn Asp Ser 
                245                 250                 255     


Glu Val Ala Pro Lys Leu Ser Glu Arg Arg Leu Met Leu Glu Val Met 
            260                 265                 270         


Thr Ala Leu Arg Ile Arg Leu Ala Glu Lys Lys Leu Ser Asn Glu Lys 
        275                 280                 285             


Ser Glu Val Gln Ile Ser Leu Asp Ile Leu Asn Glu Leu Lys Lys Cys 
    290                 295                 300                 


Pro Phe Glu Leu Tyr Glu Leu Leu Gly Ser Glu Asp Lys Arg Leu Phe 
305                 310                 315                 320 


Thr Ile Val Ala Asp Thr Gly Glu Thr Ile Leu Leu Arg Arg His Glu 
                325                 330                 335     


Asp Arg Phe Pro Gln Leu Ala Leu Ser Trp Ile Asp Ser Ser Lys Ala 
            340                 345                 350         


Phe Asp His Leu Arg Phe Gln Val Asn Ala Gly Lys Leu Arg Tyr Leu 
        355                 360                 365             


Phe Arg Asp Asn Lys His Cys Ile Asp Gly Gln Thr Arg Met Arg Val 
    370                 375                 380                 


Leu Glu Glu Pro Leu Asn Gly Tyr Arg Arg Leu Met Glu Phe Glu Glu 
385                 390                 395                 400 


Glu Arg Ile Gln Lys Gln Ser Gly Glu Ile Arg Ser Leu Trp Pro Gly 
                405                 410                 415     


Leu Asp Ile Leu Asn Lys Asp Glu Thr Pro Arg Asn Asp Ala Ser Val 
            420                 425                 430         


Leu Pro Tyr Ile Ser Asp Tyr Arg Val Arg Tyr Leu Phe Asp Gly Asp 
        435                 440                 445             


Asn Ile Gly Ile Ser Ile Gly Asp Phe Thr Pro Ser Ile Thr Lys Thr 
    450                 455                 460                 


Asp Glu Thr Lys Tyr Arg Val Thr Gly Lys Thr Ala Asp Cys Cys Leu 
465                 470                 475                 480 


Ser Lys Tyr Glu Leu Pro Gly Leu Leu Phe Tyr His Leu Leu Thr Leu 
                485                 490                 495     


Arg His Gly Asp Asn Lys Arg Ser Thr Lys Asn Ala Glu Asp Ile Ile 
            500                 505                 510         


Ile Asp Ala Ile Lys Arg Tyr Lys Arg Leu Phe Ser Asp Val Lys Glu 
        515                 520                 525             


Gly Ile Leu Lys Pro Ile Lys Glu Glu Asn Ala Asn Gln Leu Gly Asn 
    530                 535                 540                 


Arg Ile Trp Asn Ser Tyr Gly Ile Asp Ile Lys Asp Ile Pro Asp Lys 
545                 550                 555                 560 


Ile Ile Asp Tyr Leu Leu Val Arg Glu Cys Asn Glu Asp Glu Lys Phe 
                565                 570                 575     


Thr Ala Trp Lys Asn Gly Leu Ile Ser Glu Met Leu Gln Ser Thr Lys 
            580                 585                 590         


Asn Arg Ile Lys Arg Phe Glu Lys Asp Ser Glu Ala Val Ile Ser Ser 
        595                 600                 605             


Asp Asn Lys Pro Gly Lys Lys Asn His Val Ser Leu Lys Pro Gly Ala 
    610                 615                 620                 


Tyr Ala Ser Phe Ile Ala Asn Asp Ile Val Phe Phe Gln Glu Cys Gly 
625                 630                 635                 640 


Ala Thr Glu Lys Met Thr Gly Leu Asn Phe Lys Val Met Gln Ser Arg 
                645                 650                 655     


Leu Ala Thr Phe Thr Lys Asp Gly Ser Thr Ser Phe Asn Ile Leu Leu 
            660                 665                 670         


Gln Thr Leu Lys Asn Ala His Leu Val Ser Asn Thr Tyr Gly Lys Gly 
        675                 680                 685             


Asp His Pro Phe Leu Tyr Arg Val Ile Lys Gln Gln Pro Ser Asp Ile 
    690                 695                 700                 


Val Gln Phe Tyr Lys Ile Tyr Leu Asn Glu Lys Val Leu Tyr Leu Gln 
705                 710                 715                 720 


Ser Asp Ile Pro Asp Asn Ala Ile Phe Leu His Gly Glu Arg Lys Arg 
                725                 730                 735     


Trp Glu Asn Arg Asn Glu Gln Tyr Tyr Arg Asp Leu Ala Glu Arg Tyr 
            740                 745                 750         


Leu Gln Arg Pro Ile Gln Leu Pro Arg Gln Leu Phe Glu Ser His Ile 
        755                 760                 765             


Arg Gln Leu Leu Leu Ser Asp Cys Ile Lys Gly Glu Arg Gly Asn Asp 
    770                 775                 780                 


Leu Lys Glu Ala Ile Asn Ser Ala Ala Ser Gln Gly Arg Cys Asn Thr 
785                 790                 795                 800 


Thr Tyr Met Ile Met Glu Tyr Phe Ala Asp Tyr Leu Cys Asp Gly Thr 
                805                 810                 815     


Gln Phe Phe Tyr Gly Leu Phe Asp Gly Asp Leu Ser His Glu Tyr Asn 
            820                 825                 830         


Tyr Arg Phe Tyr Ser Leu Ile Ser Asn Asn Ile Glu Asn Ser Lys Lys 
        835                 840                 845             


Leu Val Leu Thr Leu Lys Lys Gly Asn Asn Ser Lys Glu Ser Pro Phe 
    850                 855                 860                 


Ile Ser Ala Leu Glu Arg Gly Ile His Trp Ser Lys Met Asn Pro Leu 
865                 870                 875                 880 


Met Lys Lys Gly Leu Lys Asn Asp Ser Ser Glu Gly Asp Phe Val His 
                885                 890                 895     


Ala Ala Lys Arg Ala Tyr Lys Glu Met Thr Glu Thr Glu Arg Met Phe 
            900                 905                 910         


Arg Arg Tyr Ala Val Gln Asp Glu Val Leu Phe Leu Ala Ala Lys Ile 
        915                 920                 925             


Thr Ile Arg Arg Ala Leu Gly Leu Ser Glu Gln Tyr Asn Cys Leu Leu 
    930                 935                 940                 


Gly Asp Ile Lys Pro Gln Gly Gly Ser Leu Leu Glu Gln Thr Ile Pro 
945                 950                 955                 960 


Ser Ile Thr Thr Lys His Thr Ile Asn Thr Gly Asn Lys Lys Gln Lys 
                965                 970                 975     


Pro Lys Gln Val Gln Ile Leu Gln Lys Asn Val Lys Leu Lys Asp Phe 
            980                 985                 990         


Gly Lys Val Phe Lys Leu Leu Asn  Asp Arg Arg Ile Phe  Asp Leu Leu 
        995                 1000                 1005             


Phe Asn  Lys Gly Asn Glu Ala  Val Ser Met Thr Asp  Leu Cys Glu 
    1010                 1015                 1020             


Glu Leu  Glu Arg Tyr Asp Arg  His Arg Val Asp Val  Phe Asp Ser 
    1025                 1030                 1035             


Val Leu  Lys Tyr Glu Ser Lys  Ile Thr Lys Gly Tyr  Thr Asn Lys 
    1040                 1045                 1050             


Glu Leu  Met Asn Glu Ser Gly  Gln Ile Asp Phe Lys  Ala Ile Gln 
    1055                 1060                 1065             


Ala Phe  Asp Lys Gln Asn Thr  Thr Ser Asp Lys Glu  Asp Leu Arg 
    1070                 1075                 1080             


Leu Ile  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Gln Tyr Asn 
    1085                 1090                 1095             


Asn Glu  Pro Ile Leu Phe Asp  Lys Asp Ile Pro Glu  Ile Ala Asp 
    1100                 1105                 1110             


Glu Ile  Ser Ile Ile Ala Lys  Asp Ile Glu Glu Asn  Thr Lys 
    1115                 1120                 1125         


<210>  2046
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2046

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Ala Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Leu Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2047
<211>  1144
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2047

Met Asn Thr Gln Pro Val Gly Leu Gly Val Tyr Tyr Ser His Thr Ser 
1               5                   10                  15      


Lys Lys Asp Lys His Phe Phe Gly Gly Phe Leu Asn Leu Gly Ile Asn 
            20                  25                  30          


Asn Leu Glu Val Leu Ile Glu Ala Phe Asn Leu Lys Phe Phe Pro Lys 
        35                  40                  45              


Asp Lys Lys Thr Ile Asp Ile Lys Asn Phe Val Gln Ile Cys Phe Gly 
    50                  55                  60                  


Ile Lys Ile Ser Asp His Asp Phe Glu Ser Arg Val Glu Phe Leu Gln 
65                  70                  75                  80  


Lys Tyr Leu Pro Val Val Arg Tyr Leu Asp Lys Arg Asn Lys Glu Ser 
                85                  90                  95      


Phe Lys Asn Gln Val Asp Leu Leu Phe Arg Ser Leu Asp Ser Leu Arg 
            100                 105                 110         


Asn Phe Tyr Thr His Tyr Tyr His Gly Pro Leu Ser Leu Pro Glu Ala 
        115                 120                 125             


Leu Phe Asp Leu Leu Asp Asp Thr Phe Ser Lys Val Ala Ser His Val 
    130                 135                 140                 


Lys Ser Asn Lys Val Lys Asp Asp Lys Ser Gln His Leu Leu Lys Ser 
145                 150                 155                 160 


Ser Leu Ser Glu Glu Leu Asp Ala Arg Tyr Lys Leu Gln Leu Glu Arg 
                165                 170                 175     


Leu Lys Ala Ala Gly Lys Lys Val Tyr Leu His Asp His Asp Ala Ile 
            180                 185                 190         


Arg Asn Gly Val Leu Asn Ser Ser Phe Asp His Leu Ile Tyr Asn Asn 
        195                 200                 205             


Glu Ala Asp Ala Ala Val Val Thr Arg Arg Tyr Ala Ala His Tyr Ser 
    210                 215                 220                 


Glu Ile Glu Pro Ala Asp Asn Gly Ile Thr Ile Ser Gln Ser Gly Leu 
225                 230                 235                 240 


Leu Phe Leu Ala Gly Leu Phe Leu Lys Arg Lys Glu Val Glu Asp Leu 
                245                 250                 255     


Lys Ser Arg Val Lys Gly Phe Lys Ala Lys Ile Ile Lys Glu Gly Glu 
            260                 265                 270         


Glu Asn Ile Ser Gly Leu Lys Tyr Met Ala Thr His Trp Val Phe Ser 
        275                 280                 285             


Tyr Leu Ser Phe Lys Gln Pro Lys Gln Thr Leu Thr Asn Asp Phe Asp 
    290                 295                 300                 


Arg Glu Thr Leu Leu Leu Gln Ile Ile Asp Glu Leu Ser Lys Val Pro 
305                 310                 315                 320 


Asp Asp Val Tyr Gln Ala Phe Ser Glu Glu Thr Arg Asn Leu Phe Val 
                325                 330                 335     


Glu Asp Ile Asn Gln Tyr Leu Lys Glu Gly Asn Asp Asp Tyr Thr Leu 
            340                 345                 350         


Glu Glu Ala Gln Val Ile His Pro Val Ile Arg Lys Arg Tyr Asp Asn 
        355                 360                 365             


Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu Asp Glu Phe Ala Gly Phe 
    370                 375                 380                 


Lys Ser Leu Arg Phe Gln Val His Leu Gly Asn Tyr Val His Asp Arg 
385                 390                 395                 400 


Arg Thr Lys His Ile Ser Gly Thr Glu Leu Gln Thr Glu Arg Arg Ile 
                405                 410                 415     


Lys Glu Arg Val Lys Val Phe Gly Arg Leu Ser Asp Ala Gln Arg Leu 
            420                 425                 430         


Lys Asn Asp Phe Phe Ala Asp Glu Ser His Arg Asp Gln Glu Leu Gly 
        435                 440                 445             


Trp Glu Ile Phe Pro Asn Pro Ser Tyr Val Phe Ile Glu Asn Asn Ile 
    450                 455                 460                 


Pro Ile Tyr Phe Lys Val Asp Asn Glu Val Gly Glu Ala Met Lys Ser 
465                 470                 475                 480 


Ala Lys Ala Arg Arg Lys Ser Leu Ser Ala Asp Glu Arg Lys Val Arg 
                485                 490                 495     


Ser Glu Asp Lys Ala Gln Lys His Ile Ile Val Asn Ser Ile Ser Gln 
            500                 505                 510         


Lys Gly Leu Leu Arg Lys Asp Glu Pro Thr Ala Leu Leu Ser Leu Asn 
        515                 520                 525             


Glu Ile Pro Ala Leu Leu Tyr Glu Ile Leu Val Lys Gly Thr Ser Pro 
    530                 535                 540                 


Asp Glu Ile Glu Glu Ile Leu Lys Phe Lys Ala Val Glu Arg Val Gln 
545                 550                 555                 560 


Thr Ile Lys Asn Tyr Asn Pro Glu Gln Pro Leu Pro Ala Ser Gln Ile 
                565                 570                 575     


Ser Lys Arg Leu Arg Thr Asn Thr Ile Val Ala Gly Lys Gln Tyr Asn 
            580                 585                 590         


Leu Asp Lys Val Lys Gln Leu Leu Asp Lys Glu Ile Phe Ser Ala Asp 
        595                 600                 605             


Glu Lys Leu Ala Leu Ile Tyr Lys Asn Arg Ala Glu Leu Asn Lys Lys 
    610                 615                 620                 


Ile Gly Gly Lys Val Leu Arg Asn Tyr Ile Phe Gly Phe Ser Glu Leu 
625                 630                 635                 640 


Gly Arg Glu Ala Thr Trp Ile Ala Glu Asp Ile Lys Arg Phe Met Pro 
                645                 650                 655     


Val Pro Thr Arg Arg Glu Trp Lys Gly Tyr Gln His Ser Gln Leu Gln 
            660                 665                 670         


Gln Ser Leu Ser Tyr Tyr Glu Ser Arg Pro Asp Glu Ala Phe Asn Ile 
        675                 680                 685             


Leu Lys Asp Asn Trp Asn Phe Asp Asp Glu Ala Met Leu Trp Asn Ser 
    690                 695                 700                 


Trp Ile Lys Asp Ser Phe Lys Glu Lys Ser Phe Asp Gln Phe Tyr Glu 
705                 710                 715                 720 


Arg Tyr Leu His Gly Lys Arg Lys Tyr Leu Glu Asn Phe Leu Glu Asn 
                725                 730                 735     


Leu Gln Asn Phe Ser Pro Gly Ser Asn Lys Ile Leu Glu Lys Phe Leu 
            740                 745                 750         


Ser Gln Gln Met Pro Lys Asn Phe Phe Asp Lys Arg Leu Tyr Val Leu 
        755                 760                 765             


Glu Pro Leu Glu Arg Glu Lys Asp Lys Ile Leu Ser Tyr Pro Leu Val 
    770                 775                 780                 


Phe Pro Arg Gly Leu Phe Asp Pro Ala Pro Thr Phe Ile Lys Gly Val 
785                 790                 795                 800 


Arg Ile Thr Glu Glu Pro Glu Arg Phe Ala Ala Trp Tyr His Tyr Gly 
                805                 810                 815     


Tyr Ser Pro Asp His Pro Phe Gln Arg Phe Tyr Asp Met Glu Arg Asp 
            820                 825                 830         


Tyr Thr Asp Leu Ile Asn Thr Asp Thr Glu Asn Arg Thr Asp Ala Asp 
        835                 840                 845             


Lys Asn Lys Pro Asp Phe Thr Val Glu Gln Gln Tyr Ala Leu Ile Lys 
    850                 855                 860                 


Lys Lys Gln Asp Leu Lys Ile Lys Asn Ile Lys Ile Gln Asp Leu Phe 
865                 870                 875                 880 


Leu Lys Leu Ile Ala Glu Thr Leu Phe Gln Asp Val Phe Asp Tyr Thr 
                885                 890                 895     


Ser Glu Ile Gly Leu Ser Asp Leu Tyr Leu Thr Gln Ala Glu Arg Ile 
            900                 905                 910         


Glu Lys Glu Gln Asn Ala Ala Leu Gln Ser Val Arg Arg Ala Gly Asp 
        915                 920                 925             


Asp Ser Asp Asn Ile Ile Lys Asp Asn Phe Ile Trp Ser Lys Thr Ile 
    930                 935                 940                 


Ser Tyr Glu Lys Gly Gln Ile Tyr Glu Pro Ala Val Lys Leu Lys Asp 
945                 950                 955                 960 


Ile Gly Lys Phe Arg Tyr Phe Leu Asn Asp Gly Arg Ile Gly Arg Leu 
                965                 970                 975     


Leu Ser Tyr Asp Thr Ser Lys Ile Trp Ser Lys Ser Glu Ile Glu Asn 
            980                 985                 990         


Glu Ile Tyr Ile Gly Pro Gly Ser  Tyr Glu Ser Ile Arg  Arg Glu Ala 
        995                 1000                 1005             


Ile Phe  Lys Glu Leu Gln Lys  Leu Glu Val Lys Ile  Leu Ala Gly 
    1010                 1015                 1020             


Tyr Glu  Gly Glu His Pro Glu  Glu Leu Glu Phe Glu  Asn Asn Pro 
    1025                 1030                 1035             


Ser Phe  Lys Lys Tyr Ile Val  Asn Gly Phe Leu Arg  Lys Gln Ser 
    1040                 1045                 1050             


Asp Thr  Val Ser Glu Thr Asp  Cys Ser Trp Leu Asp  Ser Phe Arg 
    1055                 1060                 1065             


Asp Ser  Thr Phe Glu Asn Pro  Glu Val Phe Glu Asn  Leu Ser Asp 
    1070                 1075                 1080             


Lys Ala  Pro Leu Ile Gln Glu  Ala Phe Leu Leu Val  Tyr Leu Arg 
    1085                 1090                 1095             


Asn Lys  Phe Ala His Asn Gln  Leu Pro Val Lys Glu  Ala Tyr Tyr 
    1100                 1105                 1110             


Tyr Ile  Tyr Glu Asn Tyr Ser  Glu Leu Arg Gly Ser  Thr Val Ala 
    1115                 1120                 1125             


Glu Thr  Leu Leu Asn Phe Val  Ala Tyr Ala Val Asn  Ser Ile Thr 
    1130                 1135                 1140             


Lys 
    


<210>  2048
<211>  1008
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2048

Met Asp Thr Pro Asn Phe Ser Glu Arg Ile Pro Val Ser Leu Gln Ser 
1               5                   10                  15      


His Pro Tyr Tyr Phe Ala His Tyr Leu Asn Met Ala Arg His Asn Ala 
            20                  25                  30          


Tyr Val Ile Leu Glu Tyr Val Asn Arg Glu Leu Ile Lys Pro Gly Lys 
        35                  40                  45              


Asn Leu Asp Glu Asp Asn Leu Ile Gln Ser Thr Val Leu Lys Asp Gly 
    50                  55                  60                  


Tyr Phe Asp Arg Lys Pro Asp Glu Leu Ser His Arg Asn Arg Leu Leu 
65                  70                  75                  80  


Val Gln His Phe Pro Phe Leu Arg Glu Ala Glu Asn Glu Gly Ala Arg 
                85                  90                  95      


Thr Cys Asn Pro Val Ser Tyr Lys Leu Lys Thr Ala Leu Ala Ala Leu 
            100                 105                 110         


Asn Gln Trp Arg Asn Asn Ala Ser His Tyr Pro Leu Asn Gln Asn His 
        115                 120                 125             


Glu Lys Asp Phe Asp Leu Gln Pro Phe Phe Ser Phe Ala Ile Glu Ala 
    130                 135                 140                 


Cys Lys Lys Arg Met Arg Glu Val Phe Gln Pro Asp Asp Phe Tyr Leu 
145                 150                 155                 160 


Leu Glu Thr Asn Glu Lys Gln Phe Tyr Thr Leu His Asn Glu Asn Gly 
                165                 170                 175     


Phe Thr Glu Lys Gly Leu Tyr Cys Phe Ile Cys Phe Phe Leu Glu Lys 
            180                 185                 190         


Lys Tyr Ala Phe Gln Phe Leu Ala Gly Ile Lys Gly Phe Lys Asn Thr 
        195                 200                 205             


Thr Asp Asn Lys Phe Arg Ala Thr Leu Glu Thr Phe Thr Glu His Cys 
    210                 215                 220                 


Cys Arg Leu Pro Lys Pro Lys Leu Asp Ser Ser Asp Ile Lys Leu Asp 
225                 230                 235                 240 


Met Leu Gly Glu Leu Ser Arg Cys Pro Ala Pro Leu Phe Asp Leu Leu 
                245                 250                 255     


Asp Ile Glu Glu Arg Lys Lys Phe Ile Arg Glu Pro Glu Glu Val Lys 
            260                 265                 270         


Pro Asp Glu Ser Gly Asp Arg Glu Glu Val Gln Gln Val Leu Met Lys 
        275                 280                 285             


Arg Tyr Asp Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Glu Glu 
    290                 295                 300                 


Lys Asn Leu Leu Lys Gly Ile Ser Phe His Ile His Ile Gly Arg Trp 
305                 310                 315                 320 


Ile Lys Ser Glu His Thr Lys Lys Ile Met Gly Ala Glu Arg Asp Arg 
                325                 330                 335     


Arg Leu Leu Lys Asp Ile Arg Thr Phe Gly Glu Leu Lys Glu Phe Ser 
            340                 345                 350         


Pro Glu His Ala Pro Asp Tyr Trp Leu Arg Asp Gly Ile Thr Pro Asp 
        355                 360                 365             


Asp Val Asp Gln Phe Ser Pro Gln Tyr Arg Ile Val Gly Asn Arg Ile 
    370                 375                 380                 


Gly Ile Lys Leu Asn Tyr Asn Gly His Asn Arg Trp Ser Val Pro Asp 
385                 390                 395                 400 


Lys Glu Ile Asn Val Lys Pro Asp Ala Ile Ile Ser Thr Tyr Glu Phe 
                405                 410                 415     


Leu Asn Leu Phe Leu Tyr Glu His Leu Tyr Gln Lys Lys Leu Thr Gly 
            420                 425                 430         


Leu Ser Pro Ala Glu Phe Ile Gln Asp Tyr Leu Asp Arg Phe Asn Asn 
        435                 440                 445             


Phe Leu Ser Glu Phe Lys Ala Gly His Ile Arg Pro Val Gly Asp Phe 
    450                 455                 460                 


Ser Leu Glu Lys Arg Arg Gly Gln Gly Asp Glu Pro Asp Leu Thr Ala 
465                 470                 475                 480 


Arg Arg Lys Ser Leu Gln Lys Glu Leu Asp Arg Phe Val Leu Lys Gly 
                485                 490                 495     


Lys Asp Leu Pro Asp Lys Ile Arg Glu Tyr Leu Leu Gly Tyr Lys Gln 
            500                 505                 510         


Lys Ser Glu Lys Lys Gln Ala Lys Trp Ile Leu Gly Gly Met Ile Lys 
        515                 520                 525             


Glu Thr Val Tyr Trp Arg Asn Lys Ala Glu Gln Ser Pro Glu Lys Met 
    530                 535                 540                 


Arg Ser Gly Asp Met Ala Gln Gln Leu Ala Arg Asp Ile Ile Phe Leu 
545                 550                 555                 560 


Thr Pro Pro His Thr Val Lys Glu His Lys Gln Lys Leu Asn Ser Leu 
                565                 570                 575     


Glu Tyr Asp Val Leu Gln Tyr Ala Leu Ala Tyr Phe Ser Ser Asn Arg 
            580                 585                 590         


Glu Lys Leu Tyr Ser Phe Phe Lys Glu His Gln Leu Thr Val Lys Gly 
        595                 600                 605             


Asp Arg Ala His Pro Phe Leu Tyr Lys Ile Arg Leu Asp Glu Cys Gln 
    610                 615                 620                 


Gly Ile Leu Asp Phe Phe Ile Val Tyr Met Gln Gln Lys Glu Lys Trp 
625                 630                 635                 640 


Leu Gly Trp Leu Asp Arg Asn Leu Lys Ser Pro Arg Leu Asn Glu Glu 
                645                 650                 655     


Glu Phe Phe Asn Thr Tyr Ser Tyr Phe Ile Lys Thr Asp Thr Lys Arg 
            660                 665                 670         


Ala Ile Glu Met Asp Tyr Glu Ser Cys Pro Asn Tyr Leu Pro Arg Gly 
        675                 680                 685             


Ile Phe Asn Glu Pro Ile Ala Lys Ala Leu Gln Lys Ala Gly Val Lys 
    690                 695                 700                 


Ile Lys Asp Glu Asp Asn Ala Ser Tyr Ala Leu Ser Val Tyr Ser Asn 
705                 710                 715                 720 


Gly Lys Thr Gln Pro Phe Tyr Asn Lys Glu Arg Tyr Tyr Asn Lys Gly 
                725                 730                 735     


Ile Phe Arg Met Glu Glu Leu Pro Glu Lys Leu Gln Pro Lys Glu Leu 
            740                 745                 750         


Leu Gly Lys Ile Gln Trp Thr Ile Lys Ser Ser Gly Lys Asp Thr Glu 
        755                 760                 765             


Glu Phe Arg Ser Leu Gln Asn Leu Lys Asn Arg Ile Leu Asn Thr Glu 
    770                 775                 780                 


Lys Glu Ile Arg Tyr Val Gln Ser Thr Asp Arg Ala Leu Trp Ile Met 
785                 790                 795                 800 


Val Ala Asp Leu Phe Pro Glu Thr Phe Glu Leu Arg Pro Asp Asp Leu 
                805                 810                 815     


Glu Cys Ile Gly His Asp Leu Ser Asp Asp Leu Leu Ser Arg Pro Tyr 
            820                 825                 830         


Gln Met Lys Glu Lys Val Tyr Asn Tyr Thr Ile Thr Asp Tyr Leu Pro 
        835                 840                 845             


Ile Lys Arg Tyr Gly Glu Phe Arg Arg Phe Leu Lys Asp Arg Arg Leu 
    850                 855                 860                 


Glu Asn Leu Leu Thr Tyr Phe Glu Glu Gly Val Pro Leu His Arg Glu 
865                 870                 875                 880 


Ala Leu Val Ala Glu Leu Glu Ala Tyr Asp Leu Gln Arg Lys Asn Leu 
                885                 890                 895     


Leu Glu Ile Ile Tyr Arg Phe Glu Lys Leu Val Phe Asp Arg His Arg 
            900                 905                 910         


His Glu Leu Thr Phe Ser Gly Glu Gly Glu Asn Gln Tyr Val Asn His 
        915                 920                 925             


Trp Asp Tyr Leu Asp Phe Val Ala Arg Lys Tyr Gly Leu Ser Ala Glu 
    930                 935                 940                 


Val Lys Glu Leu Asn Ser Glu Arg Phe Thr Glu Leu Arg Asn Lys Met 
945                 950                 955                 960 


Leu His Asn Gln Ile Pro Tyr Gln Leu Trp Ile Lys Glu Ala Ile Ala 
                965                 970                 975     


Ala Arg Glu Glu Asn Thr Val Cys Gly Arg Ile Met Gly Met Ile Gly 
            980                 985                 990         


Glu Ile Tyr Glu Arg Met Thr Thr  Glu Ile Glu Lys Gln  Met Gln Val 
        995                 1000                 1005             


<210>  2049
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2049

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Ala Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2050
<211>  1134
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2050

Met Asn Glu Thr Asp Tyr Leu Ala Lys Arg Leu Glu Tyr Asn Tyr Ala 
1               5                   10                  15      


Ser Ile Glu Asp Lys His Tyr Phe Gly Gly Tyr Phe Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asn Asp Leu Ser Lys Ala Phe Lys Glu Lys Phe Gly Met 
        35                  40                  45              


Lys Pro Lys Ser Cys Ile Leu Asp Phe Phe Thr Gln Asp Lys Ala Ile 
    50                  55                  60                  


Ala Glu Tyr Gln Leu Gly Val Glu Phe Leu Gln Lys Asn Leu Pro Val 
65                  70                  75                  80  


Ile Arg Tyr Leu Tyr Leu Pro Thr Ser His Lys Arg Phe Glu Asn Val 
                85                  90                  95      


Pro Lys Asn Gln Leu Ile Ser Glu Gln Arg Asn Tyr Phe Lys Asn Ser 
            100                 105                 110         


Leu Lys Val Leu Lys Asn Leu Ile Arg Asp Tyr Arg Asn Phe Tyr Thr 
        115                 120                 125             


His His Phe His Lys Pro Ile Pro Val Phe Pro Glu Thr Tyr Lys Leu 
    130                 135                 140                 


Leu Asp Asp Leu Phe Leu Ala Val Ala Asn Asp Val Lys Lys His Arg 
145                 150                 155                 160 


Met Lys Thr Asp Ala Ser Lys Gln Leu Leu Lys Lys Gly Leu Ile Glu 
                165                 170                 175     


Glu Leu Ala Gln Leu Glu Lys Leu Lys Leu Glu Asp Leu Lys Lys Leu 
            180                 185                 190         


Lys Arg Glu Gly Lys Lys Val Asn Leu Asn Asp Lys Glu Ala Ile Thr 
        195                 200                 205             


Asn Ala Ile Leu Asn Asp Ser Phe Ser His Leu Leu Pro Lys Glu Asn 
    210                 215                 220                 


Thr Ile Ser Lys Tyr Tyr Ser Ala Val Pro Thr Glu Asp Ile Asp Thr 
225                 230                 235                 240 


Glu Asn Gly Val Thr Ile Ser Glu Ser Gly Ile Ile Phe Leu Leu Gly 
                245                 250                 255     


Leu Phe Leu Thr Lys Lys Gln Ser Glu Asp Leu Arg Ser Arg Val Lys 
            260                 265                 270         


Gly Phe Lys Ala Lys Leu Ile Val Asn Pro Glu Asn Pro Ile Asn Lys 
        275                 280                 285             


Lys Asn Asn Ser Leu Lys Tyr Met Ala Thr His Trp Val Phe Gly Tyr 
    290                 295                 300                 


Leu Gly Phe Lys Gly Leu Lys Asn Arg Phe Thr Thr Thr Phe Thr Lys 
305                 310                 315                 320 


Asp Thr Leu Leu Ala Gln Ile Val Asp Glu Leu Ser Lys Val Pro Asp 
                325                 330                 335     


Glu Leu Tyr Gln Val Leu Pro Glu Glu Leu Lys Asn Glu Phe Leu Glu 
            340                 345                 350         


Asp Met Asn Glu Tyr Leu Lys Glu Glu Asn Ser Glu Ser Leu Asp Lys 
        355                 360                 365             


Ala Thr Val Ile His Pro Val Ile Arg Lys Arg Tyr Glu Asn Lys Phe 
    370                 375                 380                 


Ala Tyr Phe Ala Leu Arg Phe Leu Asp Glu Phe Val Asp Phe Pro Thr 
385                 390                 395                 400 


Leu Arg Phe Gln Leu His Leu Gly Asn Tyr Val His Asp Lys Arg Glu 
                405                 410                 415     


Lys Pro Ile Glu Gly Thr Lys Tyr Val Thr Glu Arg Ile Val Lys Glu 
            420                 425                 430         


Lys Ile Lys Ala Phe Ala Lys Leu Ser Glu Ala Ala Gln Leu Lys Gln 
        435                 440                 445             


Lys Tyr Phe Glu Glu Lys Glu Asn His Gln Ser Ile Gly Leu Gln Leu 
    450                 455                 460                 


Tyr Pro Asn Pro Ser Tyr Asn Phe Val Gly Asn Asn Ile Pro Ile His 
465                 470                 475                 480 


Leu Asn Leu Asn Glu His Phe Phe Pro Lys Glu Val Lys Ile Val Ala 
                485                 490                 495     


Gly Arg Leu Lys Lys Arg Asn Ser Ser Tyr Lys Ser Asp His Pro Glu 
            500                 505                 510         


Glu Tyr Lys Val Arg Thr Asp Asn Lys Ile Lys Pro Asp Ala Ile Leu 
        515                 520                 525             


Gln Asp Leu Gly Lys Pro Glu Lys Leu Ala Pro Val Ala Met Leu Ser 
    530                 535                 540                 


Leu Asn Glu Leu Pro Ala Leu Leu His Leu Val Leu Thr Lys Lys Thr 
545                 550                 555                 560 


Pro Glu Glu Ile Glu Ile Ile Ile Ala Gln Lys Ile Ala Glu Arg Tyr 
                565                 570                 575     


Asn Val Leu Thr Asn Tyr Lys Ala Gly Asp Asp Ile Ser Lys Gly Gln 
            580                 585                 590         


Ile Thr Lys Asn Leu Leu Lys Ala Lys Gln Lys Lys Glu Val Asn Leu 
        595                 600                 605             


Asp Lys Leu Gln Leu Ala Ile Glu Lys Glu Ile Ala Val Thr Asn Asp 
    610                 615                 620                 


Lys Leu Gln Thr Ile Ala Leu His Ile Lys Glu Arg Asn Asp Pro Lys 
625                 630                 635                 640 


Gln Lys Arg Lys Tyr Val Phe Thr Asn Lys Glu Ile Gly Leu Gln Val 
                645                 650                 655     


Thr Trp Leu Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Gly Ser Arg 
            660                 665                 670         


Gln Asn Trp Arg Gly Gln His His Ser Gln Leu Gln Lys Ser Leu Ala 
        675                 680                 685             


Phe Tyr Asp Ile Gln Pro Lys Glu Pro Leu Ser Leu Leu Glu Glu Val 
    690                 695                 700                 


Trp Asp Phe Lys Asn Glu Ala Tyr Leu Trp Asn Asn Gly Ile Arg Arg 
705                 710                 715                 720 


Ser Phe Asp Lys Arg Asp Phe Ile Ser Phe Tyr Thr Ser Tyr Leu Asn 
                725                 730                 735     


Asn Arg Lys Glu Thr Phe Gln Arg Phe Lys Asp Gln Leu Asn Gly Ile 
            740                 745                 750         


Arg Ser Asn Lys Lys Ile Leu Asp Lys Phe Ile Lys Gln Gln His Leu 
        755                 760                 765             


Trp Asn Leu Phe His Lys Arg Leu Tyr Val Ile Asp Thr Ile Glu Glu 
    770                 775                 780                 


Gln Val Glu Lys Leu Leu Val Lys Pro Met Gln Phe Pro Lys Gly Val 
785                 790                 795                 800 


Phe Asp His Lys Pro Thr Tyr Ile Lys Gly Lys Ser Ile Gln Glu Asn 
                805                 810                 815     


Pro Glu Cys Phe Ala Asp Trp Tyr Val Ala Trp Asn Gln His Thr Asp 
            820                 825                 830         


Tyr Gln Lys Phe Tyr Ser Trp Asp Arg Asp Tyr Lys Ser Ala Tyr Leu 
        835                 840                 845             


Ser Gly Glu Gln Glu Lys Thr Glu Lys Arg Phe Ile Arg Val Gln Gly 
    850                 855                 860                 


Ser Lys Ile Asn Lys Val Lys Gln Gln Asp Val Leu Leu Ala Lys Met 
865                 870                 875                 880 


Ala Ser Ile Ile Phe Asn Glu Leu Tyr Leu Pro Glu Asp Ala Glu His 
                885                 890                 895     


Leu Asp Leu Asn Leu Ser Asp Ile Tyr Lys Thr Gln Thr Glu Arg Lys 
            900                 905                 910         


Ala Glu Ile Glu Ala Ala Leu Ile Gln Ser His Lys Thr Thr Gly Asp 
        915                 920                 925             


Asn Ser Ala Asn Ile Ile Lys Ser Thr Ser Ala Trp Thr Leu Thr Val 
    930                 935                 940                 


Pro Tyr Cys Ser Lys Asn Ile Tyr Glu Pro Gln Val Lys Leu Lys Glu 
945                 950                 955                 960 


Leu Gly Lys Phe Lys Lys Phe Ile Ala Ser Gln Lys Val Gln Thr Leu 
                965                 970                 975     


Phe Glu Tyr Lys Pro Gln Lys Ile Trp Asn Lys Thr Glu Leu Glu Glu 
            980                 985                 990         


Val Leu Glu Leu Lys Ala Asn Ser  Tyr Glu Val Ile Arg  Arg Asp Tyr 
        995                 1000                 1005             


Leu Leu  Lys Ser Ile Gln Glu  Phe Glu Lys Tyr Met  Ile Lys Lys 
    1010                 1015                 1020             


Leu Pro  Thr Leu Ile Asp Thr  Asn Glu His Pro Asn  Phe Asn Lys 
    1025                 1030                 1035             


Tyr Leu  Thr Thr Phe Leu Lys  Ser Leu Glu Leu Val  Ser Glu Glu 
    1040                 1045                 1050             


Asp Ala  Lys Trp Leu Ile Ser  Lys Lys Asp Phe Asp  Thr Thr Pro 
    1055                 1060                 1065             


Ile Asp  Glu Leu Lys Lys Gln  Ser Lys Ile Met Glu  Lys Ala Phe 
    1070                 1075                 1080             


Leu Leu  Val Met Ile Arg Asn  Lys Phe Ser His Asn  Gln Leu Pro 
    1085                 1090                 1095             


Arg Lys  Ile Tyr Tyr Asp Glu  Ile Tyr Lys Asn Val  Pro Asn Ala 
    1100                 1105                 1110             


Val Ser  Ile Asn Phe Asn Glu  Leu Phe Leu Glu Tyr  Thr Asn Gln 
    1115                 1120                 1125             


Thr Ile  Leu Glu Phe Lys 
    1130                 


<210>  2051
<211>  1134
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2051

Met Asn Glu Thr Asp Tyr Leu Ala Lys Arg Leu Glu Tyr Asn Tyr Ala 
1               5                   10                  15      


Ser Ile Glu Asp Lys His Tyr Phe Gly Gly Tyr Phe Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asn Asp Leu Ser Lys Ala Phe Lys Glu Lys Phe Gly Met 
        35                  40                  45              


Lys Pro Lys Ser Cys Ile Leu Asp Phe Phe Thr Gln Asp Lys Ala Ile 
    50                  55                  60                  


Ala Glu Tyr Gln Leu Gly Val Glu Phe Leu Gln Lys Asn Leu Pro Val 
65                  70                  75                  80  


Ile Arg Tyr Leu Tyr Leu Pro Thr Ser His Lys Arg Phe Glu Asn Val 
                85                  90                  95      


Pro Lys Asn Gln Leu Ile Ser Glu Gln Arg Asn Tyr Phe Lys Asn Ser 
            100                 105                 110         


Leu Lys Val Leu Lys Asn Leu Ile Arg Asp Tyr Arg Asn Phe Tyr Thr 
        115                 120                 125             


His His Phe His Lys Pro Ile Pro Val Phe Pro Glu Thr Tyr Lys Leu 
    130                 135                 140                 


Leu Asp Asp Leu Phe Leu Ala Val Ala Asn Asp Val Lys Lys His Arg 
145                 150                 155                 160 


Met Lys Thr Asp Ala Ser Lys Gln Leu Leu Lys Lys Gly Leu Ile Glu 
                165                 170                 175     


Glu Leu Ala Gln Leu Glu Lys Leu Lys Leu Glu Asp Leu Lys Lys Leu 
            180                 185                 190         


Lys Arg Glu Gly Lys Lys Val Asn Leu Asn Asp Lys Glu Ala Ile Thr 
        195                 200                 205             


Asn Ala Ile Leu Asn Asp Ser Phe Ser His Leu Leu Pro Lys Glu Asn 
    210                 215                 220                 


Thr Ile Ser Lys Tyr Tyr Ser Ala Val Pro Thr Glu Asp Ile Asp Thr 
225                 230                 235                 240 


Glu Asn Gly Val Thr Ile Ser Glu Ser Gly Ile Ile Phe Leu Leu Gly 
                245                 250                 255     


Leu Phe Leu Thr Lys Lys Gln Ser Glu Asp Leu Arg Ser Arg Val Lys 
            260                 265                 270         


Gly Phe Lys Ala Lys Leu Ile Val Asn Pro Glu Asn Pro Ile Asn Lys 
        275                 280                 285             


Lys Asn Asn Ser Leu Lys Tyr Met Ala Thr His Trp Val Phe Gly Tyr 
    290                 295                 300                 


Leu Gly Phe Lys Gly Leu Lys Asn Arg Phe Thr Thr Thr Phe Thr Lys 
305                 310                 315                 320 


Asp Thr Leu Leu Ala Gln Ile Val Asp Glu Leu Ser Lys Val Pro Asp 
                325                 330                 335     


Glu Leu Tyr Gln Val Leu Pro Glu Glu Leu Lys Asn Glu Phe Leu Glu 
            340                 345                 350         


Asp Met Asn Glu Tyr Leu Lys Glu Glu Asn Ser Glu Ser Leu Asp Lys 
        355                 360                 365             


Ala Thr Val Ile His Pro Val Ile Arg Lys Arg Tyr Glu Asn Lys Phe 
    370                 375                 380                 


Ala Tyr Phe Ala Leu Arg Phe Leu Asp Glu Phe Val Asp Phe Pro Thr 
385                 390                 395                 400 


Leu Arg Phe Gln Leu His Leu Gly Asn Tyr Val His Asp Lys Arg Glu 
                405                 410                 415     


Lys Pro Ile Glu Gly Thr Lys Tyr Val Thr Glu Arg Ile Val Lys Glu 
            420                 425                 430         


Lys Ile Lys Ala Phe Ala Lys Leu Ser Glu Ala Ala Gln Leu Lys Gln 
        435                 440                 445             


Lys Tyr Phe Glu Glu Lys Glu Asn His Gln Ser Ile Gly Leu Gln Leu 
    450                 455                 460                 


Tyr Pro Asn Pro Ser Tyr Asn Phe Val Gly Asn Asn Ile Pro Ile His 
465                 470                 475                 480 


Leu Asn Leu Asn Glu His Phe Phe Pro Lys Glu Val Lys Ile Val Ala 
                485                 490                 495     


Gly Arg Leu Lys Lys Arg Asn Ser Ser Tyr Lys Ser Asp His Pro Glu 
            500                 505                 510         


Glu Tyr Lys Val Arg Thr Asp Asn Lys Ile Lys Pro Asp Ala Ile Leu 
        515                 520                 525             


Gln Asp Leu Gly Lys Pro Glu Lys Leu Ala Pro Val Ala Met Leu Ser 
    530                 535                 540                 


Leu Asn Glu Leu Pro Ala Leu Leu His Leu Val Leu Thr Lys Lys Thr 
545                 550                 555                 560 


Pro Glu Glu Ile Glu Ile Ile Ile Ala Gln Lys Ile Ala Glu Arg Tyr 
                565                 570                 575     


Asn Val Leu Thr Asn Tyr Lys Ala Gly Asp Asp Ile Ser Lys Gly Gln 
            580                 585                 590         


Ile Thr Lys Asn Leu Leu Lys Ala Lys Gln Lys Lys Glu Val Asn Leu 
        595                 600                 605             


Asp Lys Leu Gln Leu Ala Ile Glu Lys Glu Ile Ala Val Thr Asn Asp 
    610                 615                 620                 


Lys Leu Gln Thr Ile Ala Leu His Ile Lys Glu Arg Asn Asp Pro Lys 
625                 630                 635                 640 


Gln Lys Arg Lys Tyr Val Phe Thr Asn Lys Glu Ile Gly Leu Gln Val 
                645                 650                 655     


Thr Trp Leu Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Gly Ser Arg 
            660                 665                 670         


Gln Asn Trp Arg Gly Gln His His Ser Gln Leu Gln Lys Ser Leu Ala 
        675                 680                 685             


Phe Tyr Asp Ile Gln Pro Lys Glu Pro Leu Ser Leu Leu Glu Glu Val 
    690                 695                 700                 


Trp Asp Phe Lys Asn Glu Ala Tyr Leu Trp Asn Asn Gly Ile Arg Arg 
705                 710                 715                 720 


Ser Phe Asp Lys Arg Asp Phe Ile Ser Phe Tyr Thr Ser Tyr Leu Asn 
                725                 730                 735     


Asn Arg Lys Glu Thr Phe Gln Arg Phe Lys Asp Gln Leu Asn Gly Ile 
            740                 745                 750         


Arg Ser Asn Lys Lys Ile Leu Asp Lys Phe Ile Lys Gln Gln His Leu 
        755                 760                 765             


Trp Asn Leu Phe His Lys Arg Leu Tyr Val Ile Asp Thr Ile Glu Glu 
    770                 775                 780                 


Gln Val Glu Lys Leu Leu Val Lys Pro Met Gln Phe Pro Lys Gly Val 
785                 790                 795                 800 


Phe Asp His Lys Pro Thr Tyr Ile Lys Gly Lys Ser Ile Gln Glu Asn 
                805                 810                 815     


Pro Glu Cys Phe Ala Asp Trp Tyr Val Ala Trp Asn Gln His Thr Asp 
            820                 825                 830         


Tyr Gln Lys Phe Tyr Ser Trp Asp Arg Asp Tyr Lys Ser Ala Tyr Leu 
        835                 840                 845             


Ser Gly Glu Gln Glu Lys Thr Glu Lys Arg Phe Ile Arg Val Gln Gly 
    850                 855                 860                 


Ser Lys Ile Asn Lys Val Lys Gln Gln Asp Val Leu Leu Ala Lys Met 
865                 870                 875                 880 


Ala Ser Ile Ile Phe Asn Glu Leu Tyr Leu Pro Glu Asp Ala Glu His 
                885                 890                 895     


Leu Asp Leu Asn Leu Ser Asp Ile Tyr Lys Thr Gln Thr Glu Arg Lys 
            900                 905                 910         


Ala Glu Ile Glu Ala Ala Leu Ile Gln Ser His Lys Thr Thr Gly Asp 
        915                 920                 925             


Asn Ser Ala Asn Ile Ile Lys Ser Thr Ser Ala Trp Thr Leu Thr Val 
    930                 935                 940                 


Pro Tyr Cys Ser Lys Asn Ile Tyr Glu Pro Gln Val Lys Leu Lys Glu 
945                 950                 955                 960 


Leu Gly Lys Phe Lys Lys Phe Ile Ala Ser Gln Lys Val Gln Thr Leu 
                965                 970                 975     


Phe Glu Tyr Lys Pro Gln Lys Ile Trp Asn Lys Thr Glu Leu Glu Glu 
            980                 985                 990         


Val Leu Glu Leu Lys Ala Asn Ser  Tyr Glu Val Ile Arg  Arg Asp Tyr 
        995                 1000                 1005             


Leu Leu  Lys Ser Ile Gln Glu  Phe Glu Lys Tyr Met  Ile Lys Lys 
    1010                 1015                 1020             


Leu Pro  Thr Leu Ile Asp Thr  Asn Glu His Pro Asn  Phe Asn Lys 
    1025                 1030                 1035             


Tyr Leu  Thr Thr Phe Leu Lys  Ser Leu Glu Leu Val  Ser Glu Glu 
    1040                 1045                 1050             


Asp Ala  Lys Trp Leu Ile Ser  Lys Lys Asp Phe Asp  Thr Thr Pro 
    1055                 1060                 1065             


Ile Asp  Glu Leu Lys Lys Gln  Ser Lys Ile Met Glu  Lys Ala Phe 
    1070                 1075                 1080             


Leu Leu  Val Met Ile Arg Asn  Lys Phe Ser His Asn  Gln Leu Pro 
    1085                 1090                 1095             


Arg Lys  Ile Tyr Tyr Asp Glu  Ile Tyr Lys Asn Val  Pro Asn Ala 
    1100                 1105                 1110             


Val Ser  Ile Asn Phe Asn Glu  Leu Phe Leu Glu Tyr  Thr Asn Gln 
    1115                 1120                 1125             


Thr Ile  Leu Glu Phe Lys 
    1130                 


<210>  2052
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2052

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Ala Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Leu Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2053
<211>  1192
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2053

Met Ala Phe Asp Lys Pro Arg Pro Lys Arg Arg Gln Ala Arg Ser Asp 
1               5                   10                  15      


Phe Tyr Ile Thr Asp Lys Ala Ile Met Gly Gly Tyr Phe Asn Leu Ala 
            20                  25                  30          


Gln Leu Asn Phe Phe Lys Thr Leu Met Glu Ile Phe Thr Lys Ala Gly 
        35                  40                  45              


Ile Asp Val Ser Lys Ile Arg Gln Asp Asn Ser Pro Lys Tyr Leu Met 
    50                  55                  60                  


Ile Leu Ile Lys Lys Leu Thr His Asp Asp Glu Lys Ile Asp Asp Lys 
65                  70                  75                  80  


Lys Trp Ala Asp Ala Leu Asp Leu Ser Asn Glu Cys Leu Leu Lys Leu 
                85                  90                  95      


Gln Gln Leu Leu Tyr Lys His Phe Pro Phe Leu Gly Pro Val Met Gly 
            100                 105                 110         


Gly Glu Ala Ser Tyr Asn Ile Tyr Lys Leu Lys Asp Gly His Pro Glu 
        115                 120                 125             


Val Lys Ile Ala Asn Asn Val Met Arg Gly Val Lys Leu Glu Asp Cys 
    130                 135                 140                 


Leu Ala Val Ile Arg His Phe Ala Leu Cys Leu Asn Asp Cys Arg Asn 
145                 150                 155                 160 


Phe Tyr Thr His Phe Asn Pro Tyr Asn Pro Ile Asp Ala Gln Lys Glu 
                165                 170                 175     


Gln Tyr Leu Ser Gln Asn Lys Val Ala Val Trp Leu Asp Lys Val Lys 
            180                 185                 190         


Asp Ala Ser Arg Arg Ile Ile Lys Gln Asn Asn Gln Leu Thr Ser Gln 
        195                 200                 205             


Asp Met Glu Phe Leu Thr Gly Asp Arg Met Lys Pro Gln Asp Lys Val 
    210                 215                 220                 


Asp Glu Phe Gly Asn Ile Met Thr Asp Lys Lys Gly Tyr Thr Ile Lys 
225                 230                 235                 240 


Glu Tyr Val Glu Tyr Glu Asp Tyr Tyr Phe Arg Ile Arg Gly Lys Arg 
                245                 250                 255     


Tyr Leu Val Asp Ala Ala Gly Ala Lys Leu Val Asp Gln Glu Pro Arg 
            260                 265                 270         


Asn Ala Leu Ser Asp Phe Gly Val Val Phe Leu Cys Thr Leu Phe Leu 
        275                 280                 285             


Glu Ser Asp Gln Ala Arg Arg Met Leu Asp Glu Leu Arg Leu Phe Glu 
    290                 295                 300                 


Thr Gly Pro Tyr Asp Gly Ser Arg Asp Gly Asp Glu Phe Lys Asn Asp 
305                 310                 315                 320 


Ile Leu Arg Glu Ile Leu Leu Phe Tyr Arg Thr Arg Val Pro Arg Gly 
                325                 330                 335     


Lys Arg Leu Asp Pro Met Asp Asp Thr Thr Leu Leu Ala Met Asp Met 
            340                 345                 350         


Leu Asn Glu Leu Arg Lys Cys Pro Met Pro Leu Tyr Asp Val Leu Ser 
        355                 360                 365             


Arg Glu Gly Gln Gly Phe Phe Glu Asp Glu Val Lys Arg Pro Asn Asp 
    370                 375                 380                 


Leu Thr Pro Glu Val Ala Lys Arg Leu Arg Ser Ser Asp Arg Phe Pro 
385                 390                 395                 400 


Tyr Leu Ala Leu Arg Tyr Ile Asp Leu Asn Lys Cys Phe Gly Asn Ile 
                405                 410                 415     


Arg Phe Gln Val Gln Leu Gly Glu Phe Arg Tyr Lys Phe Tyr Asp Lys 
            420                 425                 430         


Thr Thr Ile Asp Gly Glu Gln Val Val Arg Gly Leu Gln Lys Glu Val 
        435                 440                 445             


Asn Ala Tyr Gly Arg Leu Gln Asp Val Glu Arg Tyr Arg Leu Glu Lys 
    450                 455                 460                 


Tyr Ala Asp Met Leu Gln Gln Thr Glu Leu Val Glu Thr Gly Glu Glu 
465                 470                 475                 480 


Asp Ile Thr Ile Ala Asn Phe Ile Pro Asp Thr Pro Gln Ser Ser Pro 
                485                 490                 495     


Tyr Leu Ser Asp Arg Thr Ala Ser Tyr Asn Ile His Asn Asn Arg Ile 
            500                 505                 510         


Gly Leu Leu Trp Asn Met Pro Gly Glu His Glu Val Leu Thr Gly Asp 
        515                 520                 525             


Glu Lys Met Tyr Leu Pro Asp Leu Lys Val Asp Glu Asn Gly Lys Ala 
    530                 535                 540                 


Asp Val Phe Leu Pro Ala Pro Arg Ala Ser Leu Ser Val Arg Asp Leu 
545                 550                 555                 560 


Pro Ala Leu Val Phe Tyr Leu Tyr Leu His Asn Gln Tyr Pro Asp Leu 
                565                 570                 575     


Thr Pro Ala Glu Ala Ile Ile Gln Gln Lys Tyr Asn Ala Leu Val Arg 
            580                 585                 590         


Phe Phe Asp Asp Val Ser Thr Gly His Met Leu Pro Val Asn Gly Ile 
        595                 600                 605             


Glu Glu Leu Glu Lys Ala Ile Asp Gln Tyr Gly His Leu Thr Val Asn 
    610                 615                 620                 


Glu Ile Pro Glu Lys Leu Arg Asp Tyr Leu Ala Gly Ser Ala Arg Ala 
625                 630                 635                 640 


Glu Asn Asp Asp Asp Cys Gly Val Arg Phe Asp Trp Tyr Ala Leu Gly 
                645                 650                 655     


Val Leu Glu Lys Arg Tyr Lys Gln Val Arg Ala Arg Ile Asp Gln Leu 
            660                 665                 670         


Lys Glu Ala Arg Lys Met Val Gly Asp Lys Met Asn Arg Tyr Gly Lys 
        675                 680                 685             


Lys Ser Tyr Ile Asp Val Arg Pro Arg Arg Leu Ala Glu Gln Leu Ala 
    690                 695                 700                 


Gln Ser Ile Val Asp Trp Gln Pro Ser Thr Asp Asn Gly Arg His Lys 
705                 710                 715                 720 


Met Thr Gly Lys Asn Phe Gln Arg Leu Ile Ala Phe Leu Ala Arg Tyr 
                725                 730                 735     


Thr Asp Glu Val Pro Val Gln Glu Ile Lys Asp Leu Met Thr Arg Ala 
            740                 745                 750         


Arg Leu Leu Glu Gly Pro Val Ala His Pro Phe Leu Gln Gln Val Leu 
        755                 760                 765             


Asp Lys Asn Pro Leu Asn Ile Glu Val Leu Tyr Asp Leu Tyr Phe Lys 
    770                 775                 780                 


Glu Glu Lys Arg Tyr Leu Asp Lys Tyr Ile Asp Ile Glu Ile Asn Lys 
785                 790                 795                 800 


Gln Gly Glu Glu Val Tyr Trp Ile Lys Pro Asp Ala Asp Leu Ser Lys 
                805                 810                 815     


Ile Pro Phe Leu Asn Ser Ser Arg Leu Arg Phe His Lys Leu Asp Ser 
            820                 825                 830         


Ala Tyr Tyr Gln Arg Leu Ala Ala Arg Tyr Leu Gln Val Asp Gly Arg 
        835                 840                 845             


Gln Ser Thr Ile Leu Leu Pro Asp Gly Leu Phe Thr Pro His Ile Leu 
    850                 855                 860                 


Ser Val Leu Lys Ser Thr Leu Tyr Gln Glu Asn Arg Asp Leu Gln Asp 
865                 870                 875                 880 


His Leu Gln Asp Gln Glu Leu Asn Arg Asn Ala Ser Tyr Leu Met Ser 
                885                 890                 895     


Val Tyr Leu Glu His Val Leu His Asp Ser Ala Gln Pro Phe Tyr Met 
            900                 905                 910         


Pro Asn Ser Asn Asp Ser Pro Phe Ala Arg Arg Tyr Asp Leu Phe Ala 
        915                 920                 925             


Ile Val Gln Asn Asn Lys Lys Gly Ile Glu Leu Leu Pro Cys Pro Leu 
    930                 935                 940                 


Thr Pro Val Glu Ile Asn Arg Arg Leu Thr Gly Lys Thr Pro Asp Cys 
945                 950                 955                 960 


Arg Ala Lys Leu Ile Glu Arg Asp Ile Leu Ala Leu Leu Glu Asp Met 
                965                 970                 975     


Ala Arg Lys Thr Glu Gln Arg Ile His Lys Leu Pro Gln Gly Leu Tyr 
            980                 985                 990         


Arg Lys Lys Lys Asn Glu Ala Gln  Glu Glu Arg Ile Lys  Leu Gln Gln 
        995                 1000                 1005             


Arg Met  Arg His Lys Ile Ala  Asn Val Lys Lys Asn  Glu Arg Ala 
    1010                 1015                 1020             


Ile Arg  Arg Tyr Lys Thr Gln  Asp Met Ala Val Phe  Leu Met Ala 
    1025                 1030                 1035             


Lys Gln  Met Leu Ala Asn Gln  Leu Ser Trp Gln Asn  Gln Glu Gly 
    1040                 1045                 1050             


Glu Val  Pro Phe Lys Leu Ala  Asn Val Cys Lys Glu  Gly Phe Leu 
    1055                 1060                 1065             


Arg Gln  Thr Met Lys Val Ser  Phe Pro Tyr Glu Val  Pro Leu Lys 
    1070                 1075                 1080             


Glu Asp  Lys Thr Gln Lys Ala  Thr Ile Asn Ile Val  Gln Asp Asp 
    1085                 1090                 1095             


Met Ser  Leu Lys Asn Tyr Gly  Leu Leu Tyr Lys Leu  Tyr His Asp 
    1100                 1105                 1110             


Glu Arg  Val Val Thr Leu Leu  Gln Asn Ile Val Asp  Gln Gln Gln 
    1115                 1120                 1125             


Ile Ser  Phe Ala Glu Leu Thr  Ala Glu Leu Ser Leu  Tyr Asp Gln 
    1130                 1135                 1140             


Asn Arg  Ser Lys Ala Phe Ser  Asn Phe Gln Gln Phe  Glu Lys Leu 
    1145                 1150                 1155             


Ala Phe  Glu Thr Asn Lys Glu  Ala Leu Ser Asn Pro  Glu His Arg 
    1160                 1165                 1170             


Gly Phe  Phe Leu Glu Lys Val  Asn Lys Lys Asn Gln  Val Ile Arg 
    1175                 1180                 1185             


Tyr Glu  Arg Arg 
    1190         


<210>  2054
<211>  1361
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2054

Met Gly Lys Asn Tyr Tyr Ser Lys Asn Gly Asn Ala Ser Asn Lys Asn 
1               5                   10                  15      


Ala Lys Val Gln Lys Ala Pro Arg Leu Thr Asn Glu Pro Phe Thr Ile 
            20                  25                  30          


Arg Glu Asp Asp Lys Lys Ile Tyr Gly Ala Tyr Phe Asn Met Ala Leu 
        35                  40                  45              


Asp Asn Phe Phe Lys Thr Ile Ala Tyr Ile Phe Asn Val Leu Asp Ile 
    50                  55                  60                  


Lys Gln Phe Val Arg Thr Lys Tyr Asp Gly Glu Tyr Val Glu Val Pro 
65                  70                  75                  80  


Met Phe Ser Glu Glu Ser Leu His Ile Ile Leu Lys Tyr Tyr Ser Lys 
                85                  90                  95      


Phe Phe Gly Gly Thr Leu Lys Ser Asp Lys Leu Lys Lys Asn Val Lys 
            100                 105                 110         


Lys Leu Ser Arg Leu Ser Ser Lys Asn Glu Glu Gln Glu Gln Lys Tyr 
        115                 120                 125             


Glu Glu Asp Leu Asp Glu Leu Ile Gln Ser Leu Gln Leu Thr Asn Glu 
    130                 135                 140                 


Gln Gln Gln Lys Phe Gln Gln Met Leu Phe Arg His Phe Pro Phe Leu 
145                 150                 155                 160 


Gly Pro Ile Met Ala Asp Tyr Ala Ser Tyr Ser Ile Tyr Gln Gln Ala 
                165                 170                 175     


Ser Lys Asp Val Ser Asp Lys Glu Glu Ile Lys Lys Arg Lys Lys Glu 
            180                 185                 190         


Ile Met Asn Ser Tyr Asp Ser Leu Arg Gly Val Thr Leu Ser Gln Cys 
        195                 200                 205             


Leu Glu Glu Leu Ser Lys Met Ala Glu Cys Leu Thr Ala Cys Arg Asn 
    210                 215                 220                 


Lys Tyr Thr His Phe Lys Pro Tyr Asn Ser Leu Glu Thr Gln Lys Thr 
225                 230                 235                 240 


Gln Leu Glu Leu Gln Phe Thr Ile Ala Lys Lys Leu Asp Lys Leu Leu 
                245                 250                 255     


Ala Ala Ser Arg Arg Leu Thr Lys Gln Asn Ile Ala Ile Thr Thr Glu 
            260                 265                 270         


Glu Met Glu Phe Ile Thr Gly Ile Asp His Tyr Glu Asn Val Asn Lys 
        275                 280                 285             


Gln Phe Ile Glu Arg Glu Asp Phe Tyr Phe Asn Pro Lys Gly Lys Gly 
    290                 295                 300                 


Met Ala Val Ile Glu Ser Asn Asp Ala Asn Gly Ala His Gln Gln Ser 
305                 310                 315                 320 


Ser Ser Thr Tyr Asp Ala Phe Ser Pro Phe Gly Ile Ala Tyr Phe Cys 
                325                 330                 335     


Ile Leu Phe Leu Ser Lys Thr Tyr Ala Arg Leu Phe Ile Asp Glu Ile 
            340                 345                 350         


Asn Leu Phe Ala Gly Ser Pro Phe Asn Asp Ser Glu Asn Ala Ile Met 
        355                 360                 365             


Arg Glu Ile Met Ser Leu Tyr Arg Val Arg Thr Pro Arg Gly Lys Arg 
    370                 375                 380                 


Leu Asp Ser Lys Ala Thr Asp Ser Thr Leu Gly Met Asp Ile Leu Asn 
385                 390                 395                 400 


Glu Leu Arg Lys Cys Pro Met Glu Leu Tyr Glu Thr Leu Ser Gln Glu 
                405                 410                 415     


Gly Arg Arg Phe Phe Glu Asp Glu Val Lys Arg Gln Asn Asp His Thr 
            420                 425                 430         


Pro Glu Val Val Lys Arg Leu Arg Ser Thr Asp Arg Phe Pro Tyr Leu 
        435                 440                 445             


Ala Met Arg Tyr Ile Asp Glu Thr Arg Met Phe Asp Asp Ile Arg Phe 
    450                 455                 460                 


Gln Val Arg Leu Gly Ser Tyr Arg Phe Arg Phe Tyr Lys Lys Ile Asp 
465                 470                 475                 480 


Cys Val Asp Gly Val Asp Arg Val Arg Arg Ile Gln Lys Glu Ile Asn 
                485                 490                 495     


Gly Phe Gly Arg Leu Gln Asp Ile Glu Asn Glu Arg Lys Thr Asn Trp 
            500                 505                 510         


Glu Ala Gln Met Gln Asp Ala Asn Tyr Lys Ser Val Lys Leu Glu His 
        515                 520                 525             


Glu Asp Leu Tyr Leu Asp Leu Arg Gln Phe Pro Lys Asp Thr Glu Ser 
    530                 535                 540                 


Gln Gln Pro Tyr Ile Thr Asp Arg Arg Ala Glu Tyr Asn Ile His Asn 
545                 550                 555                 560 


Asn Arg Ile Gly Leu Tyr Trp Asn Arg Glu Thr Asp Thr Pro Glu Tyr 
                565                 570                 575     


Leu Asp Asp Ala Lys Cys Phe Leu Pro Lys Leu Glu Thr Thr Gly Asp 
            580                 585                 590         


Ala Gly Lys Arg Lys Ala Gln Ile Ile Gln Pro Ala Pro Leu Cys Thr 
        595                 600                 605             


Leu Ser Val Arg Glu Leu Pro Ala Met Leu Phe Tyr Gln Trp Leu Cys 
    610                 615                 620                 


Asp Asn Tyr Lys Thr Asp Met Pro His Asp Ser Ala Glu Leu Leu Ile 
625                 630                 635                 640 


Lys Lys Lys Tyr Asp Ser Leu Val Arg Leu Phe Thr Ala Ile Lys Asn 
                645                 650                 655     


Gly Thr Phe Ser Tyr Lys Thr Thr Glu Glu Ala Thr Val Lys Tyr Leu 
            660                 665                 670         


Lys Asn Lys Phe Lys Leu Thr Leu Ala Asp Val Pro Gln Lys Leu Arg 
        675                 680                 685             


Met Tyr Ile Val Gly Lys Glu Thr His Pro Leu Gln Arg Leu Ile Glu 
    690                 695                 700                 


Val Thr Phe Asp Gly Tyr Glu Asp Asn Ser Gly Lys His Lys Gly Lys 
705                 710                 715                 720 


Leu Glu Gln Arg Arg Glu Lys Ile Glu Arg Arg Leu Glu Lys Tyr Lys 
                725                 730                 735     


Asp Asp Arg Lys Lys Ile Gly Asp Lys Thr Asn Thr Tyr Gly Lys Lys 
            740                 745                 750         


Ser Phe Val Asp Val Arg Leu Gly Ser Leu Ala Lys Phe Leu Ala Arg 
        755                 760                 765             


Asp Ile Ile Glu Trp Gln Pro Ser Asn Asn Glu Gly Arg Asp Lys Met 
    770                 775                 780                 


Thr Gly Met Asn Tyr Thr Val Met Gln Ser Phe Leu Ala Ser Tyr Gly 
785                 790                 795                 800 


Thr Lys Gln Ala Glu Gln Glu Gly Lys Thr Arg Ile Ser Ile Thr Gln 
                805                 810                 815     


Met Phe Thr Asn Ala Lys Leu Leu Asn Gly Pro Thr Ala His Pro Phe 
            820                 825                 830         


Leu Gln Asn Val Leu Asn Lys Gly Ala Lys Asn Ile Glu Lys Phe Tyr 
        835                 840                 845             


Leu Asp Tyr Leu Gln Glu Glu Ile Asp His Ile Lys Ser Leu Glu Asp 
    850                 855                 860                 


Arg Val Lys Asn Gly Glu Ala Lys Glu Ile Val Ile Arg Asp Ile Pro 
865                 870                 875                 880 


Phe Ile His Pro Asp Arg Val Lys Tyr Thr Asp Arg Ser Thr Asp Glu 
                885                 890                 895     


Ala Ile Arg Lys Gln Ala Ala Arg Tyr Met Glu Ile Glu Asp Lys Asp 
            900                 905                 910         


Ala Asp Gly Asn Thr Val Ile His Arg Thr Thr Ile Met Leu Pro Asp 
        915                 920                 925             


Gly Met Phe Ile Thr Tyr Ile Asn Asp Ile Leu Arg Ser Thr Ala Lys 
    930                 935                 940                 


Ser Lys Glu Phe Arg Lys Phe Ile Ser Pro Leu Pro Ser Tyr Ala Ser 
945                 950                 955                 960 


Asp Ala Asp Arg Lys Lys Lys Ser Asp Glu Leu Lys Asn Thr Ala Tyr 
                965                 970                 975     


Thr Ile Ser Arg Phe Phe Glu Tyr Glu Leu Gly Asp Lys Ser Gln Leu 
            980                 985                 990         


Phe Tyr Tyr Ala Asn Asp Thr Leu  Asn Gly Asp Lys Gln  Glu Met Phe 
        995                 1000                 1005             


Ala Arg  Asn Tyr Lys Leu Phe  Gln Thr Leu Arg Gly  Ile Lys Ser 
    1010                 1015                 1020             


Gly Pro  Gly Lys Leu Pro Tyr  Tyr Leu Ser Pro Ser  Gln Ile Leu 
    1025                 1030                 1035             


Thr Gly  Val Lys Asn Ile Gln  Ser Glu Ile Asp Thr  Tyr Ile Lys 
    1040                 1045                 1050             


Asp Asn  Arg Gln Ser Arg Lys  Tyr Lys Ile Glu His  Pro Lys Phe 
    1055                 1060                 1065             


Gly Lys  Gln Lys Ile Phe Gly  Glu Arg Leu Met Ala  Tyr Leu Asn 
    1070                 1075                 1080             


Glu Glu  Asp Glu Lys Glu Arg  Lys Thr Ile Ser Ile  Leu Leu Ser 
    1085                 1090                 1095             


Glu Cys  Lys His Asn Glu Lys  Thr Ile Arg Arg Tyr  Lys Thr Gln 
    1100                 1105                 1110             


Asp Met  Val Leu Phe Leu Met  Ala Lys Asp Leu Leu  Gly Lys Tyr 
    1115                 1120                 1125             


Ile Lys  Asp Glu Asp Thr Gln  Glu Glu Asn Ser Leu  Phe Met Leu 
    1130                 1135                 1140             


His Asn  Val Cys Asp Asp Lys  Phe Leu Arg Arg Thr  Val Arg Tyr 
    1145                 1150                 1155             


Glu Phe  Pro Ile Arg Val Asn  Glu Glu Arg Thr Val  Arg Val Val 
    1160                 1165                 1170             


Gln Pro  Asn Met Ser Leu Lys  Asn Tyr Gly Glu Phe  Tyr Arg Leu 
    1175                 1180                 1185             


Leu Ser  Asp Glu Arg Phe Leu  Asn Val Ile Glu Arg  Phe Lys Asp 
    1190                 1195                 1200             


Ile Asp  Val Tyr Asn Tyr Asn  Lys Leu Met Ala Glu  Leu Asn Ser 
    1205                 1210                 1215             


Tyr Asp  Ser Lys Arg Ser Ser  Ile Phe Gly Ile Val  His Tyr Leu 
    1220                 1225                 1230             


Glu Glu  Ile Ile Tyr Gly Thr  Asn Asp Ile Leu Arg  Asp Glu His 
    1235                 1240                 1245             


Glu Asn  Glu Ala Gly Phe His  Val Glu Asp Asn Pro  Glu Lys Ala 
    1250                 1255                 1260             


Ala Arg  Arg Asn Asn Phe Arg  Ser Met Leu Tyr Ile  Tyr Asp Lys 
    1265                 1270                 1275             


Glu Ala  Glu Lys Glu Lys Arg  Asn Ala Ile Phe Glu  Leu Leu Ile 
    1280                 1285                 1290             


Ser Ile  Arg Asn Ala Phe Gly  His Asn His Leu Arg  Ile Pro Phe 
    1295                 1300                 1305             


Gln Glu  Trp Met Thr Asp Glu  Glu Lys Lys Ala Phe  Lys Ser Trp 
    1310                 1315                 1320             


Ile Ser  Lys Asp Asp Glu Val  Arg Glu Lys Gly His  Glu Arg Ile 
    1325                 1330                 1335             


Ala Pro  Pro Thr Ile Ala Glu  Arg Ile Leu Ala Tyr  Thr Glu Lys 
    1340                 1345                 1350             


Thr Ala  Glu Glu Thr Gly Ile  Ile 
    1355                 1360     


<210>  2055
<211>  1146
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2055

Met Glu Ser Ile Ile Gly Leu Gly Leu Ser Phe Asn Pro Tyr Lys Thr 
1               5                   10                  15      


Ala Asp Lys His Tyr Phe Gly Ser Phe Leu Asn Leu Ala Asp Asn Asn 
            20                  25                  30          


Leu Lys Ala Val Phe Ala Glu Phe Lys Glu Arg Ile Ser Asp Lys Ser 
        35                  40                  45              


Lys Asp Glu Asp Ile Ser Asn Leu Ile Glu Lys His Phe Ile Asp Asn 
    50                  55                  60                  


Met Ser Ile Val Asp Tyr Glu Lys Asn Ile Ser Ile Leu Asn Gly Tyr 
65                  70                  75                  80  


Leu Pro Ile Ile Asp Phe Leu Asp Asp Glu Leu Glu Asn Asn Leu Asn 
                85                  90                  95      


Thr Arg Val Lys Asn Phe Lys Lys Ser Phe Ile Ile Leu Ala Glu Ala 
            100                 105                 110         


Leu Glu Thr Leu Arg Asn Tyr Tyr Thr His Phe Tyr His Asp Pro Ile 
        115                 120                 125             


Thr Phe Gly Asp Asn Lys Glu Pro Leu Leu Glu Leu Leu Asp Glu Val 
    130                 135                 140                 


Leu Leu Lys Thr Ile Leu Asp Val Lys Lys Lys Tyr Leu Lys Thr Asp 
145                 150                 155                 160 


Lys Thr Lys Glu Ile Leu Lys Asp Ser Leu Arg Glu Glu Met Asp Leu 
                165                 170                 175     


Leu Val Ile Arg Lys Thr Asp Glu Leu Arg Glu Lys Lys Lys Thr Asn 
            180                 185                 190         


Pro Lys Phe Lys Phe Ser Thr Asp Pro Thr Gln Ile Arg Asn Ser Ile 
        195                 200                 205             


Phe Asn Asp Ala Phe Gln Gly Leu Leu Tyr Glu Asp Lys Glu Asn Asn 
    210                 215                 220                 


Gly Lys Thr Gln Val Ser Tyr Arg Ala Lys Thr Lys Leu Asn Pro Lys 
225                 230                 235                 240 


Asp Ile His Lys Gln Glu Glu Arg Asp Phe Glu Ile Pro Leu Ser Thr 
                245                 250                 255     


Ser Gly Ile Val Phe Leu Met Ser Leu Phe Leu Ser Lys Lys Glu Ile 
            260                 265                 270         


Glu Asp Phe Lys Ser Asn Ile Lys Gly Phe Lys Gly Lys Val Val Lys 
        275                 280                 285             


Asp Glu Asn His Asn Ser Leu Lys Tyr Met Ala Thr His Arg Val Tyr 
    290                 295                 300                 


Ser Ile Leu Ala Phe Lys Gly Leu Lys Tyr Arg Ile Lys Thr Asp Thr 
305                 310                 315                 320 


Phe Ser Lys Val Thr Leu Met Met Gln Met Ile Asp Glu Leu Ser Lys 
                325                 330                 335     


Val Pro Asp Cys Val Tyr Gln Asn Leu Ser Glu Thr Lys Gln Lys Asp 
            340                 345                 350         


Phe Ile Glu Asp Trp Asn Glu Tyr Leu Lys Asp Asn Glu Glu Asn Thr 
        355                 360                 365             


Glu Asn Leu Glu Asn Ser Arg Val Val His Pro Leu Ile Arg Lys Arg 
    370                 375                 380                 


Tyr Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe 
385                 390                 395                 400 


Ala Asn Phe Lys Thr Leu Lys Phe Gln Val Phe Met Gly Tyr Tyr Ile 
                405                 410                 415     


His Asp Gln Arg Thr Lys Thr Ile Gly Thr Thr Asn Ile Thr Thr Glu 
            420                 425                 430         


Arg Thr Val Lys Glu Lys Ile Asn Val Phe Gly Lys Leu Ser Lys Met 
        435                 440                 445             


Asp Asn Leu Lys Lys His Phe Phe Ser Gln Leu Ser Asp Glu Glu Asn 
    450                 455                 460                 


Thr Asp Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Phe Leu Thr Gln 
465                 470                 475                 480 


Ala Asp Asn Ser Pro Ala Asn Asn Ile Pro Ile Tyr Leu Glu Leu Lys 
                485                 490                 495     


Asn Gln Gln Ile Ile Lys Glu Lys Asp Asp Ile Lys Ala Glu Val Asn 
            500                 505                 510         


Asn Ser Gln Asn Arg Asn Pro Asn Lys Pro Ser Lys Arg Asp Leu Leu 
        515                 520                 525             


Asn Lys Ile Ser Asn Thr Asn Glu Asp Phe Tyr Gln Gly Asp Pro Thr 
    530                 535                 540                 


Ala Ile Leu Ser Leu Asn Glu Ile Pro Ala Leu Leu His Leu Phe Leu 
545                 550                 555                 560 


Val Gln Pro Asp Asn Lys Thr Gly Gln Gln Ile Glu Asn Ile Ile Arg 
                565                 570                 575     


Ile Lys Ile Glu Lys Gln Phe Asn Ser Ile Lys Asn Pro Ser Lys Asp 
            580                 585                 590         


Asp Lys Gly Val Pro Lys Ser Leu Phe Ala Asp Thr Asn Val Arg Val 
        595                 600                 605             


Asn Ala Ile Lys Leu Lys Lys Asp Leu Gly Glu Glu Leu Asp Met Leu 
    610                 615                 620                 


Asn Lys Lys Gln Ile Val Phe Lys Glu Asn Gln Lys Ala Ser Ser Asn 
625                 630                 635                 640 


Tyr Asp Glu Leu Leu Lys Lys His Gln Phe Thr Pro Lys Asn Lys Arg 
                645                 650                 655     


Pro Ala Leu Arg Lys Tyr Val Phe Tyr Asn Ser Glu Lys Gly Glu Glu 
            660                 665                 670         


Ala Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Lys Gly Phe 
        675                 680                 685             


Lys Thr Lys Trp Lys Gly Tyr Gln His Ser Glu Leu Gln Arg Lys Leu 
    690                 695                 700                 


Ala Phe Tyr Asp Arg His Thr Lys Gln Asp Ile Lys Glu Leu Leu Ser 
705                 710                 715                 720 


Gly Cys Glu Phe Asp His Phe Leu Leu Asp Ile Asn Ala Cys Phe Lys 
                725                 730                 735     


Glu Asp Asp Phe Glu Asp Phe Phe Ser Lys Tyr Leu Lys Asn Arg Ile 
            740                 745                 750         


Glu Thr Leu Asn Ile Ile Leu Lys Gln Leu His Asp Phe Lys Asn Glu 
        755                 760                 765             


Pro Thr Pro Leu Lys Gly Val Phe Lys Asn Cys Leu Lys Phe Leu Lys 
    770                 775                 780                 


Gln Lys Asn Tyr Val Thr Glu Asn Pro Glu Ile Ile Lys Lys Arg Ile 
785                 790                 795                 800 


Leu Ala Lys Pro Ala Phe Leu Pro Arg Gly Ile Phe Asp Glu Arg Pro 
                805                 810                 815     


Thr Met Lys Lys Gly Lys Asn Pro Leu Ile Asp Arg Asp Glu Phe Ala 
            820                 825                 830         


Lys Trp Phe Val Glu Tyr Leu Glu Asn Lys Asp Tyr Gln Lys Phe Tyr 
        835                 840                 845             


Asn Ser Glu Glu Tyr Arg Ile Arg Asp Ala Asp Phe Lys Lys Asn Ala 
    850                 855                 860                 


Val Ile Lys Lys Gln Lys Leu Lys Asp Phe Tyr Thr Leu Gln Met Val 
865                 870                 875                 880 


Asn Tyr Leu Leu Lys Glu Val Phe Gly Lys Asp Glu Met Asn Leu Gln 
                885                 890                 895     


Leu Ser Glu Leu Phe Gln Thr Arg Gln Glu Arg Leu Lys Leu Gln Gly 
            900                 905                 910         


Ile Ala Lys Lys Gln Met Asn Lys Glu Thr Gly Asp Ser Ser Glu Asn 
        915                 920                 925             


Thr Arg Asn Gln Thr Tyr Ile Trp Asn Lys Asp Val Pro Val Ser Phe 
    930                 935                 940                 


Phe Asn Gly Lys Val Thr Ile Asp Lys Val Lys Leu Lys Asn Ile Gly 
945                 950                 955                 960 


Lys Tyr Lys Arg Tyr Glu Arg Asp Glu Arg Val Lys Thr Phe Ile Gly 
                965                 970                 975     


Tyr Glu Val Asp Glu Lys Trp Met Met Tyr Leu Pro His Asn Trp Lys 
            980                 985                 990         


Asp Arg Tyr Ser Val Lys Pro Ile  Asn Val Ile Asp Leu  Gln Ile Gln 
        995                 1000                 1005             


Glu Tyr  Glu Glu Ile Arg Ser  His Glu Leu Leu Lys  Glu Ile Gln 
    1010                 1015                 1020             


Asn Leu  Glu Gln Tyr Ile Tyr  Asp His Thr Thr Asp  Lys Asn Thr 
    1025                 1030                 1035             


Leu Leu  Gln Asp Gly Asn Pro  Asn Phe Lys Met Tyr  Val Leu Asn 
    1040                 1045                 1050             


Gly Leu  Leu Thr Gly Ile Lys  Gln Val Asn Ile Ala  Asp Phe Ile 
    1055                 1060                 1065             


Val Leu  Lys Gln Asn Thr Asn  Phe Asp Lys Ile Asp  Phe Thr Gly 
    1070                 1075                 1080             


Ile Ala  Ser Cys Ser Glu Leu  Glu Lys Lys Thr Ile  Ile Leu Ile 
    1085                 1090                 1095             


Ala Ile  Arg Asn Lys Phe Ala  His Asn Gln Leu Pro  Asn Lys Thr 
    1100                 1105                 1110             


Ile Tyr  Asp Leu Ala Asn Glu  Phe Leu Lys Lys Glu  Lys Arg Glu 
    1115                 1120                 1125             


Thr Tyr  Ala Asn Tyr Tyr Leu  Lys Val Leu Lys Lys  Met Ile Ser 
    1130                 1135                 1140             


Asp Leu  Ala 
    1145     


<210>  2056
<211>  1167
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2056

Met Asn Lys Ala Ile Phe Gly Ala Tyr Leu Asn Ala Ala Gln His Asn 
1               5                   10                  15      


Ala Tyr Met Ile Leu Asn His Ile Lys Asp Leu Val Thr Leu Lys Asp 
            20                  25                  30          


Lys Asn Asn Thr Ala Gly Ala Asp Val Glu Glu Ser Arg Leu Asp Asn 
        35                  40                  45              


Ile Asn Ile Leu Gln Leu Lys Asn Ala Pro Glu Lys Ile Ala Tyr Thr 
    50                  55                  60                  


Leu Lys Leu Leu Tyr Leu His Phe Pro Phe Leu Gly Met Leu Val Pro 
65                  70                  75                  80  


Glu Asn Ile Asn Ser Val Glu Asn Asn Tyr Glu Lys Val Ala Arg Ile 
                85                  90                  95      


Leu Lys Lys Ala Leu Val Arg Leu Asn Gln Glu Arg Asn Gln Tyr Ser 
            100                 105                 110         


His Tyr Glu Thr Gln Thr Leu Lys Thr Glu Ser His Phe Val Leu Ala 
        115                 120                 125             


Ser Thr Gln Lys Asp Leu Asp Leu Asp Glu Leu Arg Ser Thr Phe Leu 
    130                 135                 140                 


Asn Trp Phe Asn Leu Asp Asn Pro Asn Lys Glu Arg Ala Phe Ala Arg 
145                 150                 155                 160 


Tyr Pro Phe Met Asp Gly Glu Ala Arg Asn Phe Met Gly Leu His Ile 
                165                 170                 175     


Ala Lys Asn Ser Leu Trp Lys Asn Ser Ser Glu Ala Gly Lys Asp Phe 
            180                 185                 190         


Ser Glu Lys Gly Leu Ile Tyr Phe Leu Cys Leu Phe Leu Glu Arg Lys 
        195                 200                 205             


Gln Ala Tyr Leu Leu Leu Asn Ser Ile Gln Gly Phe Lys Gly Ser Lys 
    210                 215                 220                 


Gly Asn Lys Phe Arg Ala Val Arg Glu Met Tyr Ala His Asn Cys Cys 
225                 230                 235                 240 


Lys Leu Pro Gln Pro Arg Leu Asp Ser Ser Asp Ile Leu Leu Asp Met 
                245                 250                 255     


Leu Asn Glu Leu Asn Arg Cys Pro Lys Asp Leu Phe Gln Val Leu Gly 
            260                 265                 270         


Glu Thr Asp Gln Gln Arg Phe Met Ser Ala Ile Asp Asn Ala Ser Ala 
        275                 280                 285             


Val Val Lys Arg Gln Asp Asp Asn Gly Glu Leu Leu Glu Tyr Glu Lys 
    290                 295                 300                 


Arg Ile Arg His Gln Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe 
305                 310                 315                 320 


Asp Asp Thr Asn Ala Phe Pro Arg Leu Arg Phe Gln Leu Tyr Ile Gly 
                325                 330                 335     


Lys Leu Leu Gln Lys Thr Tyr Asp Lys Ala Leu Gln Gly Glu Thr Tyr 
            340                 345                 350         


Gln Arg Gln Ile Ala Lys Glu Ile Tyr Ala Phe Gly Lys Leu Ser Glu 
        355                 360                 365             


Phe Leu Gly Thr Gln Pro Thr Lys His Pro Leu Leu Lys Asn Met Thr 
    370                 375                 380                 


Val Tyr Glu Gln His Thr Ile Asp Thr Ala Thr Gly Ala Val Ile Asn 
385                 390                 395                 400 


Asn Pro Asn Ala Pro Glu Ile Gly Gln Ile Val Gln Phe Ser Pro Gln 
                405                 410                 415     


Tyr Asn Phe Gly Thr Asn Lys Ile Met Leu Lys Ile Gly Lys Glu Thr 
            420                 425                 430         


Thr Val Asp Ser Lys Ala Leu Glu Tyr Arg Arg Gly Glu Lys Gly Val 
        435                 440                 445             


Val Leu Lys Asp Lys Met Lys Ile Lys Lys Ile Glu Pro Glu Glu Lys 
    450                 455                 460                 


Glu Ala Ile Leu Ser Thr His Glu Leu Pro Asn Leu Phe Leu Tyr His 
465                 470                 475                 480 


Tyr Leu Tyr Lys Gln Gly His Leu Thr Ser Thr Val Glu Ser Phe Ile 
                485                 490                 495     


Glu Lys Tyr Ile Asp Thr Phe Arg Lys Phe Ile Lys Ser Val Gln Thr 
            500                 505                 510         


Lys Gln Phe Leu Pro Leu Glu Lys Ser Ala Phe Lys Arg Arg Ser Ile 
        515                 520                 525             


Ser Tyr Lys Asp Arg Lys Glu Ala Thr Ile Lys Lys Ala Pro Gln Thr 
    530                 535                 540                 


Gly Arg Glu Pro Tyr Asn Asp Lys Asn Phe Glu Glu Leu Lys Asp Arg 
545                 550                 555                 560 


Lys Thr Ala Leu Gln His Arg Leu Asp Asn Ser Asp Phe Lys Gly Leu 
                565                 570                 575     


Tyr Trp Ser Tyr Leu Pro Asp Glu Ile Val Asn Tyr Leu Leu Asn Thr 
            580                 585                 590         


Gln Pro Thr Asp Tyr Lys Thr Val Val Leu Ala Lys Ile Asp Glu Leu 
        595                 600                 605             


Lys Asp Gln Thr Asn Glu Leu Lys Gln Gln Phe Lys Arg Ile Asn Lys 
    610                 615                 620                 


Arg Lys Ala Phe Phe Glu Glu Glu Gln Glu Glu Asn Pro Thr Asn Asp 
625                 630                 635                 640 


His Thr Ala Thr Phe Ser Thr Gly Leu Arg Val Gly Glu Ile Ala Thr 
                645                 650                 655     


Trp Leu Ala Lys Asp Ile Ile Phe Leu Lys Pro Tyr Gln Lys Asp Val 
            660                 665                 670         


Lys Asn Tyr Gly Lys Pro Asn Asn Asp Gln Tyr Asn Arg Leu Gln Thr 
        675                 680                 685             


Leu Leu Ala Leu Tyr Pro Leu Tyr Lys Asp Glu Leu Pro Lys Phe Phe 
    690                 695                 700                 


Glu Glu Leu His Leu Ile Gly Gly Lys Ser Thr Glu Asn His Pro Phe 
705                 710                 715                 720 


Leu Ser Gln Asn Leu Pro Asn Ser Leu Tyr Asp Phe Tyr Gln Asn Tyr 
                725                 730                 735     


Ile Asp Ala Lys Leu Lys Trp Leu Ile Gln Leu His Thr Asp Ile Asp 
            740                 745                 750         


Gly Val Lys Arg Lys Asp Lys Ala Thr Gln Ser Ile Lys Thr Val Lys 
        755                 760                 765             


Glu Gly Leu Asn Pro Thr Gln Ile Glu Asn Leu Tyr Ser His Leu Phe 
    770                 775                 780                 


Gly Lys Ile Ser Gln Val Glu Thr Asn Ile Glu Ser Lys Lys Tyr Asp 
785                 790                 795                 800 


Thr Leu Pro Ile Ala Leu Pro Val Gly Leu Phe Asn Ala Ala Ile Leu 
                805                 810                 815     


Glu Gly Met Gln Arg Lys Gly Ile Ala Leu Ser Glu Lys Asp Asn Thr 
            820                 825                 830         


Leu Phe Ala Leu Lys Asn Leu Leu Gln Asn Asp Thr Gln Glu Phe Tyr 
        835                 840                 845             


His Tyr Pro Arg Arg Tyr Glu Thr Thr Gln Glu Ile Leu Gln Pro Phe 
    850                 855                 860                 


Leu Thr His Ser Gly Ser Ala Cys Lys Asp Leu Ala Glu Arg Glu Lys 
865                 870                 875                 880 


Leu Met Glu Ser Leu Lys Asn Glu Ile Asn Arg Leu Gly Lys Ser Thr 
                885                 890                 895     


Asn Glu Glu Lys Leu Ile Leu Arg Arg Thr Leu Val Asn Phe Arg Ser 
            900                 905                 910         


Arg Val Leu Glu Lys Glu Gln Thr Ile Arg Phe Thr Gln Gln Gln Asp 
        915                 920                 925             


Arg Cys Leu Trp Leu Met Cys Gln Glu Leu Thr Asn Tyr Arg Lys Glu 
    930                 935                 940                 


Lys Thr Gln Glu Gly Ile Gln Leu Asp Phe Thr Asn Thr Ser Leu Gln 
945                 950                 955                 960 


Lys Leu Glu Glu Leu Leu Asp Thr Asn Lys Glu Met Lys Leu Gln Val 
                965                 970                 975     


Tyr Ile Tyr Lys Thr Lys Gln Ala Ile Gly Ile Ile Thr Asp Thr Leu 
            980                 985                 990         


Pro Ile Arg Arg Tyr Gly Asp Leu  Arg Arg Phe Ala Lys  Asn Arg Gln 
        995                 1000                 1005             


Leu Pro  Asn Leu Tyr Asp Tyr  Phe Tyr Asp Glu Asn  Gln His Gln 
    1010                 1015                 1020             


Asn Gly  Asn Leu Pro Thr Phe  Ser Pro Gln Asn Leu  Gln Asp Ala 
    1025                 1030                 1035             


Leu Glu  Phe Leu Glu Lys Asn  Arg Pro Ser Ile Leu  Gln Lys Ala 
    1040                 1045                 1050             


Leu Asp  Leu Glu Glu Val Ile  Phe Ser Asn Tyr Glu  Val Glu Phe 
    1055                 1060                 1065             


Val Ala  Tyr Lys Ala Ala Asn  Ser Thr Lys Thr Asp  Pro Asp His 
    1070                 1075                 1080             


Asn Ile  Phe Ile Glu Tyr Leu  Phe Ser Lys Leu Pro  Glu Thr Thr 
    1085                 1090                 1095             


Leu Thr  Gln Ile Ala Gly Ala  Asn Thr Glu Ala Lys  Lys Ile Phe 
    1100                 1105                 1110             


Lys Leu  Arg Asn His Ile Leu  His Asn Glu Val Pro  Pro Lys Glu 
    1115                 1120                 1125             


Tyr Ile  Gly Asn His Leu Thr  Gln His Leu Gly Lys  Asn Pro Glu 
    1130                 1135                 1140             


Thr Pro  Leu Gln Val Thr Glu  Phe Ile Ile Ala His  Thr Ile Arg 
    1145                 1150                 1155             


Ile Tyr  Glu Gln Leu Ala Ala  Ala Val 
    1160                 1165         


<210>  2057
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2057

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2058
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2058

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Leu Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2059
<211>  1078
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2059

Met Ile Asn Asn Lys Asn Thr Asn Gln Ala Phe Trp Ala Ala Tyr Ser 
1               5                   10                  15      


Asn Val Ala Ala Tyr Asn Val Ala Ile Ile Ile Ala His Ile Asn Ser 
            20                  25                  30          


Lys Ile Glu Asn Lys Thr Lys Glu Ala Asp Glu Glu Ser Leu Gly Lys 
        35                  40                  45              


Ile Glu Asp Leu Phe Asp Met Val Cys Val Asp Asn Pro Asn Asn Lys 
    50                  55                  60                  


Lys Lys Ile Asp Phe Leu Tyr Lys Tyr Met Pro Phe Ile Trp Leu Phe 
65                  70                  75                  80  


Val Asp Tyr Ile Tyr Asn Gln Asp Lys Thr Ser Asn Gly Ile Pro Phe 
                85                  90                  95      


Phe Glu Lys Arg Ile Ile Asn Asn Asn Asp Lys Asn Asp Val Glu Ser 
            100                 105                 110         


Arg Glu Val Thr Leu Thr Glu Gln Ile Glu Ile Ile Lys Glu Leu Phe 
        115                 120                 125             


Gln Leu Leu Leu Asp Ile Arg Asn Asn Gln Ser His Phe Val Gly Ser 
    130                 135                 140                 


Asn Tyr Phe Val Asn Asp Ser Met Phe Arg Ala Leu Glu Tyr Cys Phe 
145                 150                 155                 160 


Asp Val Ser Leu Arg Thr Thr Ile Thr Arg Phe Trp Asp Asp Ala Lys 
                165                 170                 175     


Asp Ala Asn Asn Lys Leu Glu His Leu Lys Arg His Asp Asn Lys Gly 
            180                 185                 190         


Lys Ile Lys Lys Glu Phe Ile Tyr Lys Phe Lys Asn Ile Gly Val Asp 
        195                 200                 205             


Lys Asn Asn Phe Thr Thr Asn Gly Leu Ala Phe Phe Leu Cys Leu Phe 
    210                 215                 220                 


Leu Asp Lys Arg Met Ser Lys Leu Met Leu Asp Gln Ile Ser Gly Phe 
225                 230                 235                 240 


Lys Arg Asn Asp Ser Lys Glu Tyr Arg Ala Thr Ile Asn Val Phe Thr 
                245                 250                 255     


Ile Asp Arg Ile Arg Leu Pro Lys Glu Lys Ile Glu Ser Val Phe Ser 
            260                 265                 270         


Leu Asp Ser Leu Gly Leu Asp Ile Ile Asn Glu Leu Gln Lys Cys Pro 
        275                 280                 285             


Lys Glu Leu Tyr Asp Leu Leu Ser Gln Glu Asp Arg Asn Lys Phe Val 
    290                 295                 300                 


Leu Ile Asp Glu Glu Thr Glu Asp Glu Thr Ile Leu Lys Arg Ser Gln 
305                 310                 315                 320 


Asn Arg Phe Ser Tyr Phe Val Met Arg Tyr Phe Asp Glu Lys Glu Ile 
                325                 330                 335     


Phe Lys Asn Ile Arg Phe His Ile Asp Leu Gly Leu Tyr Asn Lys Asp 
            340                 345                 350         


Cys Tyr Glu Lys Thr Leu Lys Asp Gly Ser Lys Leu Glu Asp Arg Phe 
        355                 360                 365             


Ile Ser Lys Arg Leu Lys Gly Phe Gly Arg Ile Gln Glu Met Asn Thr 
    370                 375                 380                 


Glu Phe Glu Lys His Lys Lys Glu Tyr Pro Asp Phe Tyr Val Gln Asp 
385                 390                 395                 400 


Lys Asn Glu Lys Asn Tyr Gln Ile Pro Asn Arg Met Pro Thr Phe Pro 
                405                 410                 415     


His Tyr His Tyr Ala Asn Glu Glu Lys Thr Leu Ile Gly Leu Lys Ile 
            420                 425                 430         


Lys Asp Lys Val Asp Tyr Lys Tyr Ser Asp Ile Glu Arg Asn Asn Phe 
        435                 440                 445             


Ile Leu Glu Lys Pro Asp Ala Tyr Ile Ser Thr Tyr Glu Phe Pro Ala 
    450                 455                 460                 


Met Tyr Phe Cys Glu Tyr Leu Lys Gly Asn Pro Glu Gln Val Leu Ile 
465                 470                 475                 480 


Asp Thr Tyr Asn Thr Ile Ile Asp Phe Leu Lys Lys Ile Ala Ser Asn 
                485                 490                 495     


Asp Asn Ser Ile Glu Ile Phe Arg Asp Glu Ile Thr Gly Lys Thr Glu 
            500                 505                 510         


Asp Glu Ile Lys Glu Leu Phe Lys Asn Glu Phe Lys Leu Asp Ile Asn 
        515                 520                 525             


Asp Ile Pro Lys Glu Leu Lys Val Tyr Ile Ser Thr Lys Pro Ala Lys 
    530                 535                 540                 


Ser Lys Asn Thr Tyr Gln Glu Tyr Leu Lys Gln Lys Met Asp Thr Met 
545                 550                 555                 560 


Leu Glu Glu Ala Lys Lys Glu Tyr Gly Trp Ile Ile Asp Lys Glu Asn 
                565                 570                 575     


Arg Ile Lys Glu Arg Arg Ile Lys Ala Gly Lys Lys Asn Tyr Glu Lys 
            580                 585                 590         


Ile Asn Ile Gly Asp Ile Ala Leu Lys Leu Val Lys Asp Ile Ile Tyr 
        595                 600                 605             


Leu Thr Pro Ile Ser Ser Lys Asn Asn Gly Lys Asp Gly Ile Thr Ser 
    610                 615                 620                 


Pro Asn Tyr Asn Arg Leu Gln Glu His Phe Ala Leu Trp Val Glu Lys 
625                 630                 635                 640 


Glu Arg Arg Phe Lys Ala Ile Glu Ile Leu Asn Ala Phe Lys Ile Phe 
                645                 650                 655     


Asp Lys His Pro Phe Leu Asn Lys Leu Gly Lys Ile Glu Asp Ile Ser 
            660                 665                 670         


Ser Ile Val Ile Leu Tyr Lys Ala Tyr Met Leu Ser Lys Ile Asn Tyr 
        675                 680                 685             


Leu Asn Glu Lys Ala Val Lys Gly Lys Tyr Gly Ile Asp Ile Leu Ser 
    690                 695                 700                 


Asn Asp Lys Glu Asn Lys Lys Ala Leu Asp Tyr Glu Thr Tyr Ser Ile 
705                 710                 715                 720 


Asp Leu Ala Lys Lys Leu Leu Glu Leu Pro Ile Asn Leu Pro Arg Asn 
                725                 730                 735     


Met Phe Tyr Glu Glu Ile Val Lys Ser Lys Glu Leu Glu Thr Leu Arg 
            740                 745                 750         


Arg Tyr Ile Tyr Gly Lys Arg Ala Asn Val Ser Tyr Leu Ile Lys Leu 
        755                 760                 765             


Tyr Leu Asn Glu Lys Leu Lys Asp Asp Ser Gln Glu Phe Tyr Lys Tyr 
    770                 775                 780                 


Asp Arg Met Tyr Lys Phe Phe Lys Glu Gly Arg Asn Asn Lys Asn Val 
785                 790                 795                 800 


Tyr His Glu Leu Asn Arg Phe Asp Glu Lys Val Ser Glu Ile Lys Glu 
                805                 810                 815     


Gln Ile Lys Asn Asn Gln Asp Asn Pro Asn Tyr Lys Phe Tyr Lys Gln 
            820                 825                 830         


Phe Thr Glu Asn Glu Lys Gln Leu Arg Leu Leu Gln Thr Gln Asp Val 
        835                 840                 845             


Leu Leu Phe Leu Met Ala Lys Ser Ile Leu Phe Asn Glu Val Glu Thr 
    850                 855                 860                 


Lys Phe Ile Asp Lys Thr Ile Gln Ser Glu Ser Ile Leu Leu Lys Asn 
865                 870                 875                 880 


Ile Gly Ile Gly Gly Lys Ser Val Leu Glu Glu Lys Thr Lys Val Asn 
                885                 890                 895     


Leu Ser Leu Ser Val Ala Asp Tyr Tyr Leu Phe Ile Glu Asp Thr Leu 
            900                 905                 910         


Lys Ile Lys Asn Tyr Gly Asp Phe Lys Tyr Phe Cys Phe Asp Lys Arg 
        915                 920                 925             


Val Ser Asn Tyr Leu Glu Cys Leu Leu Lys Thr Phe Asn Asp Asn Gln 
    930                 935                 940                 


Tyr Lys Lys Gly Gly Asn Pro Tyr Lys Ile Lys Arg Gln Glu Ile Glu 
945                 950                 955                 960 


Lys Glu Leu Glu Asn Tyr Glu Thr Tyr Arg Ile Ala Ala Phe Glu Lys 
                965                 970                 975     


Ile Leu Glu Phe Glu Arg Ile Phe Phe Gln Asn Tyr Tyr Thr Lys Glu 
            980                 985                 990         


Glu Phe Glu Ser Ile Asn Asn Gly  Thr His Phe Ser Phe  Glu Lys Ile 
        995                 1000                 1005             


Ile Lys  Glu Phe Ile Glu Lys  Thr Asn Ala Glu Tyr  Glu Ile Cys 
    1010                 1015                 1020             


Lys Leu  Ile Lys Ser Thr Arg  Asn Ala Phe Ser His  Ser Gln Tyr 
    1025                 1030                 1035             


Pro Met  Gln Asp Asn Trp Leu  Arg Asn Arg Ile Asp  Glu Lys Asn 
    1040                 1045                 1050             


Lys Ser  Asn Met Leu Asp Ile  Ile Tyr Asn Asp Phe  Ser Glu Ser 
    1055                 1060                 1065             


Ile Glu  Ser Cys Lys Lys Leu  Ile Val Asn 
    1070                 1075             


<210>  2060
<211>  1078
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2060

Met Ile Asn Asn Lys Asn Thr Asn Gln Ala Phe Trp Ala Ala Tyr Ser 
1               5                   10                  15      


Asn Val Ala Ala Tyr Asn Val Ala Ile Ile Ile Ala His Ile Asn Ser 
            20                  25                  30          


Lys Ile Glu Asn Lys Thr Lys Glu Ala Asp Glu Glu Ser Leu Gly Lys 
        35                  40                  45              


Ile Glu Asp Leu Phe Asp Met Val Cys Val Asp Asn Pro Asn Asn Lys 
    50                  55                  60                  


Lys Lys Ile Asp Phe Leu Tyr Lys Tyr Met Pro Phe Ile Trp Leu Phe 
65                  70                  75                  80  


Val Asp Tyr Ile Tyr Asn Gln Asp Lys Thr Ser Asn Gly Ile Pro Phe 
                85                  90                  95      


Phe Glu Lys Arg Ile Ile Asn Asn Asn Asp Lys Asn Asp Val Glu Ser 
            100                 105                 110         


Arg Glu Val Thr Leu Thr Glu Gln Ile Glu Ile Ile Lys Glu Leu Phe 
        115                 120                 125             


Gln Leu Leu Leu Asp Ile Arg Asn Asn Gln Ser His Phe Val Gly Ser 
    130                 135                 140                 


Asn Tyr Phe Val Asn Asp Ser Met Phe Arg Ala Leu Glu Tyr Cys Phe 
145                 150                 155                 160 


Asp Val Ser Leu Arg Thr Thr Ile Thr Arg Phe Trp Asp Asp Ala Lys 
                165                 170                 175     


Asp Ala Asn Asn Lys Leu Glu His Leu Lys Arg His Asp Asn Lys Gly 
            180                 185                 190         


Lys Ile Lys Lys Glu Phe Ile Tyr Lys Phe Lys Asn Ile Gly Val Asp 
        195                 200                 205             


Lys Asn Asn Phe Thr Thr Asn Gly Leu Ala Phe Phe Leu Cys Leu Phe 
    210                 215                 220                 


Leu Asp Lys Arg Met Ser Lys Leu Met Leu Asp Gln Ile Ser Gly Phe 
225                 230                 235                 240 


Lys Arg Asn Asp Ser Lys Glu Tyr Arg Ala Thr Ile Asn Val Phe Thr 
                245                 250                 255     


Ile Asp Arg Ile Arg Leu Pro Lys Glu Lys Ile Glu Ser Val Phe Ser 
            260                 265                 270         


Leu Asp Ser Leu Gly Leu Asp Ile Ile Asn Glu Leu Gln Lys Cys Pro 
        275                 280                 285             


Lys Glu Leu Tyr Asp Leu Leu Ser Gln Glu Asp Arg Asn Lys Phe Val 
    290                 295                 300                 


Leu Ile Asp Glu Glu Thr Glu Asp Glu Thr Ile Leu Lys Arg Ser Gln 
305                 310                 315                 320 


Asn Arg Phe Ser Tyr Phe Val Met Arg Tyr Phe Asp Glu Lys Glu Ile 
                325                 330                 335     


Phe Lys Asn Ile Arg Phe His Ile Asp Leu Gly Leu Tyr Asn Lys Asp 
            340                 345                 350         


Cys Tyr Glu Lys Thr Leu Lys Asp Gly Ser Lys Leu Glu Asp Arg Phe 
        355                 360                 365             


Ile Ser Lys Arg Leu Lys Gly Phe Gly Arg Ile Gln Glu Met Asn Thr 
    370                 375                 380                 


Glu Phe Glu Lys His Lys Lys Glu Tyr Pro Asp Phe Tyr Val Gln Asp 
385                 390                 395                 400 


Lys Asn Glu Lys Asn Tyr Gln Ile Pro Asn Arg Met Pro Thr Phe Pro 
                405                 410                 415     


His Tyr His Tyr Ala Asn Glu Glu Lys Thr Leu Ile Gly Leu Lys Ile 
            420                 425                 430         


Lys Asp Lys Val Asp Tyr Lys Tyr Ser Asp Ile Glu Arg Asn Asn Phe 
        435                 440                 445             


Ile Leu Glu Lys Pro Asp Ala Tyr Ile Ser Thr Tyr Glu Phe Pro Ala 
    450                 455                 460                 


Met Tyr Phe Cys Glu Tyr Leu Lys Gly Asn Pro Glu Gln Val Leu Ile 
465                 470                 475                 480 


Asp Thr Tyr Asn Thr Ile Ile Asp Phe Leu Lys Lys Ile Ala Ser Asn 
                485                 490                 495     


Asp Asn Ser Ile Glu Ile Phe Arg Asp Glu Ile Thr Gly Lys Thr Glu 
            500                 505                 510         


Asp Glu Ile Lys Glu Leu Phe Lys Asn Glu Phe Lys Leu Asp Ile Asn 
        515                 520                 525             


Asp Ile Pro Lys Glu Leu Lys Val Tyr Ile Ser Thr Lys Pro Ala Lys 
    530                 535                 540                 


Ser Lys Asn Thr Tyr Gln Glu Tyr Leu Lys Gln Lys Met Asp Thr Met 
545                 550                 555                 560 


Leu Glu Glu Ala Lys Lys Glu Tyr Gly Trp Ile Ile Asp Lys Glu Asn 
                565                 570                 575     


Arg Ile Lys Glu Arg Arg Ile Lys Ala Gly Lys Lys Asn Tyr Glu Lys 
            580                 585                 590         


Ile Asn Ile Gly Asp Ile Ala Leu Lys Leu Val Lys Asp Ile Ile Tyr 
        595                 600                 605             


Leu Thr Pro Ile Ser Ser Lys Asn Asn Gly Lys Asp Gly Ile Thr Ser 
    610                 615                 620                 


Pro Asn Tyr Asn Arg Leu Gln Glu His Phe Ala Leu Trp Val Glu Lys 
625                 630                 635                 640 


Glu Arg Arg Phe Lys Ala Ile Glu Ile Leu Asn Ala Phe Lys Ile Phe 
                645                 650                 655     


Asp Lys His Pro Phe Leu Asn Lys Leu Gly Lys Ile Glu Asp Ile Ser 
            660                 665                 670         


Ser Ile Val Ile Leu Tyr Lys Ala Tyr Met Leu Ser Lys Ile Asn Tyr 
        675                 680                 685             


Leu Asn Glu Lys Ala Val Lys Gly Lys Tyr Gly Ile Asp Ile Leu Ser 
    690                 695                 700                 


Asn Asp Lys Glu Asn Lys Lys Ala Leu Asp Tyr Glu Thr Tyr Ser Ile 
705                 710                 715                 720 


Asp Leu Ala Lys Lys Leu Leu Glu Leu Pro Ile Asn Leu Pro Arg Asn 
                725                 730                 735     


Met Phe Tyr Glu Glu Ile Val Lys Ser Lys Glu Leu Glu Thr Leu Arg 
            740                 745                 750         


Arg Tyr Ile Tyr Gly Lys Arg Ala Asn Val Ser Tyr Leu Ile Lys Leu 
        755                 760                 765             


Tyr Leu Asn Glu Lys Leu Lys Asp Asp Ser Gln Glu Phe Tyr Lys Tyr 
    770                 775                 780                 


Asp Arg Met Tyr Lys Phe Phe Lys Glu Gly Arg Asn Asn Lys Asn Val 
785                 790                 795                 800 


Tyr His Glu Leu Asn Arg Phe Asp Glu Lys Val Ser Glu Ile Lys Glu 
                805                 810                 815     


Gln Ile Lys Asn Asn Gln Asp Asn Pro Asn Tyr Lys Phe Tyr Lys Gln 
            820                 825                 830         


Phe Thr Glu Asn Glu Lys Gln Leu Arg Leu Leu Gln Thr Gln Asp Val 
        835                 840                 845             


Leu Leu Phe Leu Met Ala Lys Ser Ile Leu Phe Asn Glu Val Glu Thr 
    850                 855                 860                 


Lys Phe Ile Asp Lys Thr Ile Gln Ser Glu Ser Ile Leu Leu Lys Asn 
865                 870                 875                 880 


Ile Gly Ile Gly Gly Lys Ser Val Leu Glu Glu Lys Thr Lys Val Asn 
                885                 890                 895     


Leu Ser Leu Ser Val Ala Asp Tyr Tyr Leu Phe Ile Glu Asp Thr Leu 
            900                 905                 910         


Lys Ile Lys Asn Tyr Gly Asp Phe Lys Tyr Phe Cys Phe Asp Lys Arg 
        915                 920                 925             


Val Ser Asn Tyr Leu Glu Cys Leu Leu Lys Thr Phe Asn Asp Asn Gln 
    930                 935                 940                 


Tyr Lys Lys Gly Gly Asn Pro Tyr Lys Ile Lys Arg Gln Glu Ile Glu 
945                 950                 955                 960 


Lys Glu Leu Glu Asn Tyr Glu Thr Tyr Arg Ile Ala Ala Phe Glu Lys 
                965                 970                 975     


Ile Leu Glu Phe Glu Arg Ile Phe Phe Gln Asn Tyr Tyr Thr Lys Glu 
            980                 985                 990         


Glu Phe Glu Ser Ile Asn Asn Gly  Thr His Phe Ser Phe  Glu Lys Ile 
        995                 1000                 1005             


Ile Lys  Glu Phe Ile Glu Lys  Thr Asn Ala Glu Tyr  Glu Ile Cys 
    1010                 1015                 1020             


Lys Leu  Ile Lys Ser Thr Arg  Asn Ala Phe Ser His  Ser Gln Tyr 
    1025                 1030                 1035             


Pro Met  Gln Asp Asn Trp Leu  Arg Asn Arg Ile Asp  Glu Lys Asn 
    1040                 1045                 1050             


Lys Ser  Asn Met Leu Asp Ile  Ile Tyr Asn Asp Phe  Ser Glu Ser 
    1055                 1060                 1065             


Ile Glu  Ser Cys Lys Lys Leu  Ile Val Asn 
    1070                 1075             


<210>  2061
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2061

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Ala Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Leu Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2062
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2062

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2063
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2063

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Lys Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Leu Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2064
<211>  1140
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2064

Met Glu Asn Asp Gln Gln Ile Leu Glu Asn Arg Arg Arg Thr Leu Ala 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Ser Asn His Leu Ala Thr Ser Phe Glu Gln Lys Ala 
        35                  40                  45              


Leu His Glu Glu Gly Gln Ile Pro Ala Ser Phe Leu Cys Asn Lys Ser 
    50                  55                  60                  


Ile Lys Lys Ile Asn Trp Asn His Val Tyr Ser Lys Ala Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Ile Phe Asp Ala Asp Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Arg Glu Thr Ser Asp Lys Glu Gly Lys Asp Phe Thr Ala Met Asn Glu 
            100                 105                 110         


Thr Leu Lys Leu Val Phe Asp Glu Leu Gln Ala Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Ala Asp Ser Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Val Glu Leu Ala Asp Phe Leu Thr Val Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Ala Asp Asp Asp Tyr 
                165                 170                 175     


Ala Val Val Glu Ser Lys Gln Ile Val Thr Pro Asp Asn Gln Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Ile Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Val Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Leu Ala Tyr Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asp Leu Arg Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Glu 
            260                 265                 270         


Val Ile Thr Glu Glu Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Glu Glu Glu Arg 
    290                 295                 300                 


Glu Lys Ile Leu Asp Glu Ile Asp Tyr Glu Asp Tyr Ile Glu Ser Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg His Ser Asn Arg Phe Pro Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Glu Lys Tyr Asn Lys Gln Phe Asp Gly Glu 
        355                 360                 365             


Ala Thr Glu Arg Lys Val Val Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asn Gln Glu Thr Val Glu Leu Lys Ile Asp Ser Ala 
385                 390                 395                 400 


Gln Arg Thr Asn Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Glu Ala Arg Leu Leu 
            420                 425                 430         


Thr Lys Ala Lys Pro Glu Ser Lys Val Ser Tyr Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Lys Ala Glu Glu Met Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Lys Val Asn Asp Ser Gln Leu Met Asn Met Gln Phe Ile Asp Glu 
                485                 490                 495     


Ile Lys Glu Gln Leu Pro Ala Asp Trp Asn Glu Phe Gly Lys Arg Ser 
            500                 505                 510         


Asp Ser Lys Lys Lys Lys Ala Tyr Thr Asn Ala Ala Arg Gln Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Lys Val Leu Ala Asn Tyr Gln Leu 
    530                 535                 540                 


Asn Asp Lys Gln Val Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Val 
545                 550                 555                 560 


Lys Glu Val Asp Asp Ser Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Met Glu Lys His Lys Val 
            580                 585                 590         


Asp Lys Ser Ala Arg Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Thr Asp Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Tyr 
625                 630                 635                 640 


Ala Asp Asn Glu Lys Lys Ala Thr Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Lys Asp Gly His Pro Phe Leu Ala Asn Ile Asn 
            660                 665                 670         


Leu Arg Gln Ile Arg Lys Thr Ser Gln Leu Tyr Glu Leu Tyr Leu Val 
        675                 680                 685             


Glu Lys Ala Asn Lys Gln Val Lys Lys Met Asn Pro Lys Thr Gln Arg 
    690                 695                 700                 


Thr Asn Asn Val Asp Glu Ser Trp Met Met Lys Ser Phe Tyr Ala Lys 
705                 710                 715                 720 


Glu Trp Asn Glu Glu Met Gly Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Thr Asn Ile Pro Phe Thr Ile Arg Gln Trp Glu Glu Lys 
            740                 745                 750         


Glu Lys His Asn Leu Gln Ala Trp Leu His Asn Ile Thr Lys Gly Lys 
        755                 760                 765             


Thr Ser Lys Asp Gly Lys Lys Ala Val Asp Leu Pro Thr Asn Leu Phe 
    770                 775                 780                 


Asp Asp Thr Leu Cys Glu Leu Leu Arg Glu Ala Leu Ile Asn Glu Gly 
785                 790                 795                 800 


Ile Asp Ala Thr Pro Thr Thr Lys Tyr Asn Glu Leu Leu Lys His Trp 
                805                 810                 815     


Trp Thr Ala Arg Glu Asp Ser Thr Gln Asp Phe Tyr Leu Ser Glu Arg 
            820                 825                 830         


Gln Tyr Asp Ile Tyr Asp Glu Lys Val Cys Phe Thr Ile Asn Ser Ser 
        835                 840                 845             


Ala His Phe Ala Asp Tyr Tyr Ala Pro Ala Leu Ser Lys Ala Tyr Ser 
    850                 855                 860                 


Arg Leu Arg Ala Glu Arg Asp Val Ala Arg Arg Thr Asp Lys Arg Leu 
865                 870                 875                 880 


Pro Pro Val Glu Arg Lys Asp Val Glu Arg Val Phe Lys Asn Thr Ile 
                885                 890                 895     


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
            900                 905                 910         


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asn Gln Gln Gln Leu Lys 
        915                 920                 925             


Leu Ser Lys Met Asp Ser Leu Leu Asn Glu Thr Lys Arg Ile Glu Gln 
    930                 935                 940                 


Val Ile Asn Thr Gln Leu Ser Phe Asp Gln Lys Gly Lys Glu Ile Lys 
945                 950                 955                 960 


Asp Lys Thr Asn Leu Glu Ile Val Lys Thr Ile Val Ala Glu Arg Lys 
                965                 970                 975     


Gln Lys Asn Tyr Thr Glu Met Arg Lys Tyr Val His Asp Arg Arg Leu 
            980                 985                 990         


Pro Glu Leu Phe Glu Tyr Ile Asp  Gly Asn Glu Leu Pro  Leu Asp Met 
        995                 1000                 1005             


Leu Leu  Asn Glu Leu Arg Ala  Tyr Asn Thr Ala Lys  Gln Val Val 
    1010                 1015                 1020             


Phe Asp  Thr Val Phe Ala Leu  Glu Lys Lys Ile Ile  Glu Thr Asp 
    1025                 1030                 1035             


Pro Glu  Gly Leu Lys Gln Leu  Asn Val Ser Lys Asp  Gly Gln Ile 
    1040                 1045                 1050             


Gln Thr  Gly Asn Ile Gln His  Lys Pro Tyr Val Gln  Trp Leu Glu 
    1055                 1060                 1065             


Asn Lys  Gly Leu Ile Thr Asp  Lys Asp Lys Gln Phe  Ile Asn Met 
    1070                 1075                 1080             


Val Arg  Asn Ser Phe Ser His  Asn Gln Phe Pro Gln  Arg Ser Thr 
    1085                 1090                 1095             


Val Glu  Leu Leu Met Pro Val  Trp Gln Asn Thr Asn  Ile Ala Leu 
    1100                 1105                 1110             


Gln Ile  Ala Arg Glu Tyr Gln  Gln Leu Ile Val Asp  Ile Ile Glu 
    1115                 1120                 1125             


Lys Ser  Leu His Pro His Lys  Gln His Gln Met Val  
    1130                 1135                 1140 


<210>  2065
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2065

Met Glu Thr Lys Gln Gln Val Gly Lys Gly Ile Ser Tyr Asp His Arg 
1               5                   10                  15      


Arg Pro Asp Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asp Gly Val Ile Gln Glu Phe Ala Met Arg Leu Asn Arg 
        35                  40                  45              


Glu Tyr Asp Pro Glu Asn Lys Asn Gln Ser Leu Phe Ser Tyr Phe Asn 
    50                  55                  60                  


Ile Asn Ala Ser Phe Thr Asp Trp Glu Arg Gly Val Asn Ile Leu Lys 
65                  70                  75                  80  


Glu Tyr Trp Pro Met Met Glu Phe Ile Asp Arg Pro Ala Thr Asp Lys 
                85                  90                  95      


Gln Phe Glu Ala Glu Lys Pro Glu Asn Arg Glu Ala Ala Lys Arg Lys 
            100                 105                 110         


Tyr Phe Leu Ala Thr Leu Gly Ala Leu Leu Thr Ser Ile Lys Asp Leu 
        115                 120                 125             


Arg His Tyr Tyr Thr His Tyr Tyr His Pro Pro Val His Leu Asn Asp 
    130                 135                 140                 


Asp Leu Phe Leu Phe Leu Asp His Ala Leu Leu Tyr Thr Ala Phe Asp 
145                 150                 155                 160 


Val Lys Lys Thr Lys Met Lys Asp Asp Lys Thr Arg Gln Leu Leu Asn 
                165                 170                 175     


Gln Asn Leu Ser Leu Glu Leu Glu Lys Leu Lys Lys Leu Lys Val Glu 
            180                 185                 190         


Glu Leu Lys Lys Lys Lys Glu Lys Gly Ile Lys Val Asn Leu Gln Asp 
        195                 200                 205             


Glu Lys Gly Ile Leu Asn Ala Ile Tyr Asn Asp Ala Phe Ala His Ile 
    210                 215                 220                 


Ile Thr Lys Glu Lys Asp Ser Asp Lys Asp Lys Leu Glu Thr Arg Tyr 
225                 230                 235                 240 


Lys Ser Ile Leu Pro Gln Asp Glu Ala Ala Glu Thr Gly Ile Asn Ile 
                245                 250                 255     


Ser Ile Ser Gly Leu Ile Phe Leu Leu Ser Leu Phe Leu Ser Arg Lys 
            260                 265                 270         


Glu Ile Glu Gln Leu Lys Ser Asn Ile Glu Gly Tyr Lys Gly Lys Val 
        275                 280                 285             


Leu Asn Ile Glu Thr Glu Val Asp Arg Lys His Asn Ser Leu Lys Tyr 
    290                 295                 300                 


Met Ala Thr His Trp Val Phe Ser Ile Leu Ala Phe Lys Gly Leu Lys 
305                 310                 315                 320 


Gln Arg Leu Thr Asn Ser Phe Glu Lys Glu Ser Leu Leu Ile Gln Met 
                325                 330                 335     


Met Asp Glu Leu Asn Lys Val Pro Asp Glu Leu Tyr Gln Thr Leu Ser 
            340                 345                 350         


Glu Thr Ala Lys Lys Glu Phe Leu Glu Asp Ile Asn Glu Tyr Val Ser 
        355                 360                 365             


Glu Gly Asp Asp Asn Glu Lys Ala Thr Tyr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Ser Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gln Phe Pro Thr Leu Lys Phe Gln Ile Phe Val Gly 
                405                 410                 415     


Gln Tyr Leu His Asp Asn Arg Pro Lys Thr Leu Ala Ser Asn Gly Met 
            420                 425                 430         


Thr Ala Gln Arg Met Ile Lys Glu Lys Ile Asn Leu Phe Gly Asn Leu 
        435                 440                 445             


Ser Glu Val Thr Lys His Lys Ser Asp Phe Phe Glu Lys Glu Ser Ala 
    450                 455                 460                 


Ala Gln Gly Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Trp Ala Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Val Tyr Ile Asp Met Ile Gly Lys Glu Gly Lys Ala 
                485                 490                 495     


Lys Glu Ile Gln Val Gln Ile Asn Lys Tyr Arg Lys Gln Leu Asn Pro 
            500                 505                 510         


Ala Pro Gln Arg Asp Lys Arg Ile Ser Lys Lys Glu Ile Ile Glu Gln 
        515                 520                 525             


Leu Tyr Lys Glu Lys Val Val Tyr Gly Asp Pro Thr Leu Met Leu Ser 
    530                 535                 540                 


Ala Asn Glu Leu Met Ala Leu Leu Tyr Glu Leu Ile Val Asn Gly Lys 
545                 550                 555                 560 


Ser Gly Ala Glu Leu Glu Asn Lys Ile Val Glu Gln Ile Ile Ala Arg 
                565                 570                 575     


Tyr Glu Gln Ile Glu Ala Tyr Asp Pro Thr Thr Gln Gln Leu Pro Thr 
            580                 585                 590         


Asn Gln Met Pro His Lys Leu Gln Lys Ser Arg Lys Asp Ser Lys Val 
        595                 600                 605             


Thr Asp Thr Asp Lys Leu Leu Lys Thr Ile Asp Lys Glu Ile Asp Glu 
    610                 615                 620                 


Gly Asn Lys Lys Leu Glu Leu Ile Ala Cys His Arg Lys Glu Trp Glu 
625                 630                 635                 640 


Glu Ala Glu Gln Arg Lys Lys Ser Gly Lys Arg Asn Asn Pro Gly Thr 
                645                 650                 655     


Lys Ser Arg Lys His Leu Phe Tyr Ala Ser Glu Met Gly Glu Glu Ala 
            660                 665                 670         


Thr Trp Ile Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Pro Ala Arg 
        675                 680                 685             


Ala Glu Trp Lys Gly Thr His His Ser Glu Leu Gln Arg Leu Leu Ala 
    690                 695                 700                 


Phe Tyr Ser Thr Gln Arg Leu Glu Ala Trp Gln Leu Val Glu Ser Val 
705                 710                 715                 720 


Trp Thr Ala Asn Thr His Ser Phe Trp Glu Glu Asn Phe Lys Glu Ala 
                725                 730                 735     


Phe Tyr Lys Pro Glu Phe Glu Asn Phe Tyr Gly Ala Tyr Ile Glu Ile 
            740                 745                 750         


Arg Thr Lys Ile Leu Thr Thr Cys Arg Ser Ile Leu Glu Asn Asn Pro 
        755                 760                 765             


Glu Ala Thr Met Asn Asn Asp Thr Glu Lys Glu Trp Asp Lys Val Phe 
    770                 775                 780                 


Thr Leu Phe Asp Lys Arg Leu Tyr Arg Thr Ser Thr Thr Asp Glu Gln 
785                 790                 795                 800 


Lys Lys Gln Leu Leu Thr Lys Pro Phe Ala Phe Pro Arg Gly Leu Phe 
                805                 810                 815     


Asp Asp Lys Pro Thr Phe Leu Pro Gly Ser Lys Pro Asn Glu Asn Pro 
            820                 825                 830         


Glu Arg Phe Ala Ala Trp Tyr Ser Tyr Gly Tyr Thr Tyr Ser Gly Lys 
        835                 840                 845             


Phe Gln Ser Phe Tyr Asp Met Pro Arg Asn Tyr Ser Asp Trp Tyr Lys 
    850                 855                 860                 


Lys Leu Lys Glu Asp Gly Lys Leu Pro Arg Leu Asp Lys Lys Thr Glu 
865                 870                 875                 880 


Gln Glu Lys Ile Leu Arg Phe Arg Met Asp Cys Asp Leu Asn Ile Lys 
                885                 890                 895     


His Ile Arg Phe Gln Asp Ile Tyr Val Lys Leu Met Val Asp Ser Leu 
            900                 905                 910         


Tyr Lys Ala Val Phe Gly Gln Gln Pro Glu Phe Asp Leu Ser His Leu 
        915                 920                 925             


Tyr Asp Thr Arg Ser Glu Arg Tyr Glu Asn Asn Thr Ile Ala Gln Arg 
    930                 935                 940                 


Gln Lys Ser Arg Gln Glu Gly Asp Asn Ser Asp Asn Ala Ile Asn Glu 
945                 950                 955                 960 


Asn Tyr Val Trp Asn Lys Thr Phe Ala Ile Ser Leu Tyr Asn Gly Arg 
                965                 970                 975     


Ile Thr Glu Ser Gln Val Lys Leu Lys Asp Val Gly Lys Phe Arg Arg 
            980                 985                 990         


Phe Ala Thr Asp Pro Arg Val Gln  Thr Leu Ile Ser Tyr  Asp Asp Thr 
        995                 1000                 1005             


Arg Thr  Trp Thr Lys Leu Glu  Ile Glu Asn Glu Leu  Asp Asn Lys 
    1010                 1015                 1020             


Ala Asp  Ala Tyr Glu Pro Ile  Arg Arg Thr Gln Ser  Leu Lys Ala 
    1025                 1030                 1035             


Ile Gln  Gln Leu Glu Lys Asn  Ile Leu Lys Lys Asn  Gly Phe Asn 
    1040                 1045                 1050             


Gly Lys  Gln His Pro Glu Glu  Leu Lys His Asn Gly  Asn Pro Asn 
    1055                 1060                 1065             


Phe Arg  Lys Tyr Ile Ala Asn  Gly Leu Leu Lys His  Arg Thr Asp 
    1070                 1075                 1080             


Ile Arg  Gln Glu Glu Leu Ala  Leu Ile Ser Asp Thr  Glu Phe Gln 
    1085                 1090                 1095             


Glu Ile  Gly Leu Glu Arg Ile  Arg Gln Thr Asn Pro  Leu Ile Gln 
    1100                 1105                 1110             


Lys Ala  Tyr Leu Leu Ile Leu  Leu Arg Asn Lys Phe  Gly His Asn 
    1115                 1120                 1125             


Gln Leu  Pro Asp Gln Glu His  Phe Arg Leu Met Arg  Ser Ile Tyr 
    1130                 1135                 1140             


Pro Tyr  Asn Gln Gln Glu Ser  Tyr Ser Ala Tyr Phe  Asn His Val 
    1145                 1150                 1155             


Ile Thr  Gln Ile Ile Glu Glu  Leu Asn Thr 
    1160                 1165             


<210>  2066
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2066

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Lys Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Leu Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2067
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2067

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2068
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2068

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2069
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2069

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2070
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2070

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2071
<211>  1110
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2071

Met Lys Ser Asn Glu Gln Thr Tyr Glu Asn Lys Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Val Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Ser Asn His Ile Ala Ser Asp Phe Gly Gln Ala Gln 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Thr Ser Phe Leu Cys Asn Lys Gly 
    50                  55                  60                  


Ile Lys Lys Leu Asn Trp Asn His Val Tyr Thr Lys Thr Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ala Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Arg Glu Asn Tyr Glu Lys Glu Gly Lys Asp Phe Ala Ala Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Thr Glu Leu Gln Ala Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Glu Asn Arg Lys Leu Thr Val 
    130                 135                 140                 


Ser Gly Glu Leu Ala Asp Phe Leu Thr Ile Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Thr Asp Ala Asp Tyr 
                165                 170                 175     


Glu Leu Val Glu Asn Arg Gln Ile Val Val Asp Asn Asn Thr Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ser Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asp Leu Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Lys 
            260                 265                 270         


Val Ser Thr Glu Glu Ala Lys Leu Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Leu Ala Asn Ser Thr Asn Ile Asp Glu Cys 
    290                 295                 300                 


Glu Lys Ile Leu Asp Glu Ile Asn Tyr Glu Asp Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg His Asn Asn Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Asp Glu Lys Asn Val Phe Glu Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Thr Tyr Thr Lys Gln Leu Ala Gly Glu 
        355                 360                 365             


Gln Thr Glu Arg Val Val Phe Glu Asn Val Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Asn Ser Phe Thr Asp Ser Glu Ser Val Gln Gln Arg Ile Asp Lys Gln 
385                 390                 395                 400 


Gln Arg Thr Gly Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Glu 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Ser Lys Glu Glu Val Ala Leu Leu Leu 
            420                 425                 430         


Pro Lys Ser Lys Pro Asp Thr Lys Val Ala Tyr Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Val Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Lys Ser Glu Gln Met Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Met Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Ser Lys Leu Pro Phe Gly Trp Asn Glu Phe Thr Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asn Ala Thr Met Lys Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Thr Ile Val Asn Asp Val Leu Ile Asp Tyr Asn Leu 
    530                 535                 540                 


Asn His Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Asp Val Glu Asp Ser Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Thr Arg Val Lys Val Leu Glu Lys His Lys Leu 
            580                 585                 590         


Asp Lys Ser Val Lys Thr Pro Lys Val Gly Glu Met Ala Ser Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Lys Glu Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Ile Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Ala Asp Ala Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Phe Glu Asn Gly Gly His Pro Phe Ile Gln Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Leu His Lys Thr Ser Gln Phe Tyr Glu Ala Tyr Leu Lys 
        675                 680                 685             


Glu Lys Gly Asn Lys Gln Val Ser Lys Phe Asn Pro Lys Thr Asn Lys 
    690                 695                 700                 


Thr Ser Lys Val Asp Asp Ser Trp Met Met Gln Gln Phe Tyr Thr Lys 
705                 710                 715                 720 


Glu Trp Asn Asp Glu Ile Lys Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Thr His Ile Pro Phe Thr Ile Arg Met Trp Glu Glu Lys 
            740                 745                 750         


Glu Lys Tyr Asn Leu Glu Thr Trp Leu His Asn Val Thr Val Gly Lys 
        755                 760                 765             


Asn Ile Lys Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe 
    770                 775                 780                 


Asp Glu Ala Leu Cys Ile Leu Leu Arg Lys Gln Leu Asp Thr Leu Ala 
785                 790                 795                 800 


Pro Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Leu Trp 
                805                 810                 815     


Trp Lys Thr Arg Asn Asp Asp Thr Gln Asp Phe Tyr Arg Ala Glu Arg 
            820                 825                 830         


Glu Tyr Ser Ile Tyr Asp Glu Lys Ile Val Phe Lys Ile Asn Ser Ser 
        835                 840                 845             


Gly His Phe Ala Asp Tyr Tyr Gln Lys Ala Leu Gly Lys Val Tyr Ser 
    850                 855                 860                 


Arg Leu Lys Ala Glu Arg Glu Thr Ala Arg Arg Thr Asn Asn Arg Leu 
865                 870                 875                 880 


Pro Pro Ile Glu His Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile 
                885                 890                 895     


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
            900                 905                 910         


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asn Ser Gln Asn Leu Lys 
        915                 920                 925             


Leu Asn Arg Ile Glu Ser Leu Leu Asn Asp Thr Thr Arg Ile Glu Gln 
    930                 935                 940                 


Lys Val Leu Ser Lys Thr Ile Val Ala Glu Arg Lys Gln Lys Asn Tyr 
945                 950                 955                 960 


Thr Glu Leu Arg Lys Tyr Ile His Asp Arg Arg Leu Pro Glu Leu Phe 
                965                 970                 975     


Glu Tyr Val Glu Ala Asp Glu Ile Gln Leu Glu Trp Leu Gln Asn Glu 
            980                 985                 990         


Leu Lys Glu Tyr Asn Thr Ala Lys  Gln Gln Val Phe Asp  Lys Val Phe 
        995                 1000                 1005             


Met Leu  Glu Lys Lys Ile Ile  Glu Thr Asp Arg Glu  Gly Val Ile 
    1010                 1015                 1020             


Glu Val  Met Ile Asn Thr Asp  Gly Val Leu Gln Lys  Gly Thr Ile 
    1025                 1030                 1035             


Gln His  Lys Pro Tyr Val Gln  Trp Met Lys Arg Lys  Gly Leu Ile 
    1040                 1045                 1050             


Ala Asp  His Glu Glu Gln Phe  Ile Asn Glu Val Arg  Asn Cys Phe 
    1055                 1060                 1065             


Ser His  Asn Gln Phe Pro His  Arg Lys Thr Met Glu  Leu Leu Ile 
    1070                 1075                 1080             


Pro Glu  Trp Ala Glu Gly Lys  Leu Ala Leu Gln Ile  Val Thr Val 
    1085                 1090                 1095             


Tyr Ser  Gln Leu Ile Ala Asp  Ile Val Asp Lys Ile  
    1100                 1105                 1110 


<210>  2072
<211>  1140
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2072

Met Glu Asn Asp Gln Gln Ile Leu Glu Asn Arg Arg Arg Thr Leu Ala 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Ser Asn His Leu Ala Ala Ser Phe Glu Gln Lys Val 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ala Ser Phe Leu Cys Asn Lys Ser 
    50                  55                  60                  


Ile Lys Lys Ile Asn Trp Asn His Val Tyr Ser Lys Ala Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ala Asp Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Arg Glu Thr Thr Asp Lys Glu Gly Lys Asp Phe Thr Ala Met Asn Glu 
            100                 105                 110         


Thr Leu Lys Leu Val Phe Asp Glu Leu Gln Ala Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Ala Asp Ser Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Val Glu Leu Ala Asp Phe Leu Thr Val Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Ala Asp Asp Asp Tyr 
                165                 170                 175     


Thr Met Val Glu Ser Lys Gln Ile Val Thr Pro Asp Asn Leu Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Val Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Leu Ala Tyr Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asp Leu Gly Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Glu 
            260                 265                 270         


Val Ile Thr Glu Glu Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Glu Glu Glu Arg 
    290                 295                 300                 


Glu Lys Ile Leu Asp Glu Ile Asp Tyr Glu Asp Tyr Ile Glu Ser Leu 
305                 310                 315                 320 


Thr Arg Arg Val Arg His Ser Asn Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Lys Tyr Asn Lys Gln Phe Asp Gly Glu 
        355                 360                 365             


Ala Thr Glu Cys Lys Val Val Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asn Gln Glu Thr Val Glu Leu Lys Ile Asp Ser Ala 
385                 390                 395                 400 


Gln Arg Thr Asn Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Glu Ala Arg Leu Leu 
            420                 425                 430         


Thr Lys Ala Lys Pro Glu Ser Lys Val Ser Tyr Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Lys Ala Glu Glu Met Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Lys Val Asn Asp Ser Gln Leu Met Ser Met Gln Phe Ile Asp Glu 
                485                 490                 495     


Ile Lys Glu Gln Leu Pro Ala Asp Trp Asn Glu Phe Gly Lys Arg Ser 
            500                 505                 510         


Asp Ser Lys Lys Lys Lys Ala Tyr Thr Asn Ala Ala Leu Gln Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Lys Val Leu Ala Asn Tyr Gln Leu 
    530                 535                 540                 


Asn Asp Lys Gln Val Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Ser Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Val Glu Lys His Lys Leu 
            580                 585                 590         


Asp Lys Ser Ala Arg Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Thr Asp Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Phe Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Tyr 
625                 630                 635                 640 


Ala Asp Thr Asp Lys Lys Ala Thr Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Lys Gly Gly His Pro Phe Leu Ala Asn Ile Asn 
            660                 665                 670         


Leu Arg Gln Ile Arg Lys Thr Ser Gln Leu Tyr Glu Leu Tyr Leu Val 
        675                 680                 685             


Glu Lys Ala Asn Lys Gln Val Lys Lys Met Asn Pro Lys Thr Gln Arg 
    690                 695                 700                 


Thr Ser Asn Val Asp Glu Ser Trp Met Met Lys Ser Phe Tyr Ala Lys 
705                 710                 715                 720 


Glu Trp Asn Glu Glu Met Gly Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Val Asn Lys Thr Asn Ile Pro Phe Thr Ile Arg Gln Trp Glu Glu Lys 
            740                 745                 750         


Glu Lys His Asn Leu Gln Ala Trp Leu His Asn Ile Thr Lys Gly Lys 
        755                 760                 765             


Thr Ser Lys Asp Gly Lys Lys Ala Ile Asp Leu Pro Thr Asn Leu Phe 
    770                 775                 780                 


Asp Asp Thr Leu Cys Glu Leu Leu Arg Glu Ala Leu Ile Asn Gln Gly 
785                 790                 795                 800 


Ile Asp Ala Thr Pro Thr Thr Lys Tyr Asn Glu Leu Leu Lys Gln Trp 
                805                 810                 815     


Trp Thr Ala Arg Glu Asp Ser Thr Gln Asp Phe Tyr Leu Ser Glu Arg 
            820                 825                 830         


Gln Tyr Asp Ile Tyr Asp Glu Lys Val Cys Phe Thr Ile Asn Ser Ser 
        835                 840                 845             


Ala His Phe Ala Asp Tyr Tyr Ala Pro Ala Leu Asn Lys Ala Tyr Ser 
    850                 855                 860                 


Arg Leu Arg Ala Glu Arg Asp Val Ala Arg Arg Thr Asp Lys Arg Leu 
865                 870                 875                 880 


Pro Pro Val Glu Arg Lys Asp Val Glu Arg Val Phe Lys Asn Thr Ile 
                885                 890                 895     


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
            900                 905                 910         


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asn Gln Gln Gln Leu Lys 
        915                 920                 925             


Leu Ser Lys Met Asp Ser Leu Leu Asn Glu Thr Lys Arg Ile Glu Gln 
    930                 935                 940                 


Thr Ile Asn Thr Gln Leu Ser Phe Asp His Lys Gly Lys Glu Ile Lys 
945                 950                 955                 960 


Asp Lys Thr Asn Ser Glu Ile Val Lys Thr Ile Val Ala Glu Arg Lys 
                965                 970                 975     


Gln Lys Asn Tyr Thr Glu Met Arg Lys Tyr Val His Asp Arg Arg Leu 
            980                 985                 990         


Pro Glu Leu Phe Glu Tyr Ile Asp  Gly Asn Glu Leu Pro  Leu Asp Val 
        995                 1000                 1005             


Leu Leu  Asn Glu Leu Arg Ala  Tyr Asn Thr Ala Lys  Gln Met Val 
    1010                 1015                 1020             


Phe Asp  Thr Val Phe Ala Leu  Glu Lys Lys Ile Ile  Glu Thr Asp 
    1025                 1030                 1035             


Pro Glu  Gly Leu Lys Gln Leu  Asn Val Gly Lys Asn  Gly Gln Ile 
    1040                 1045                 1050             


Gln Thr  Gly Asn Ile Gln His  Lys Pro Tyr Val Gln  Trp Leu Glu 
    1055                 1060                 1065             


Asn Lys  Gly Leu Ile Thr Asp  His Gln Lys Gln Phe  Ile Asn Met 
    1070                 1075                 1080             


Val Arg  Asn Ser Phe Ser His  Asn Gln Phe Pro Gln  Arg Ser Thr 
    1085                 1090                 1095             


Val Glu  Leu Leu Met Pro Glu  Trp Gln Asn Thr Asp  Ile Ala Leu 
    1100                 1105                 1110             


Gln Ile  Ala Arg Glu Tyr Gln  Gln Leu Ile Val Asp  Ile Ile Glu 
    1115                 1120                 1125             


Lys Ser  Leu His Pro His Lys  Gln His Gln Met Val  
    1130                 1135                 1140 


<210>  2073
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2073

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2074
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2074

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2075
<211>  1156
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2075

Met Glu Asn His Thr Lys Gln Thr Thr Tyr Lys Tyr Asp Glu Ile Ala 
1               5                   10                  15      


Asp Lys His Tyr Phe Ala Gly Phe Phe Asn Leu Ala Trp Asn Asn Ile 
            20                  25                  30          


Glu Ile Val Phe Lys Val Phe Leu Lys Lys Phe Lys Leu Ile Glu Asp 
        35                  40                  45              


Lys Asp Lys Lys Ile Glu Val Asn Pro Leu Ser Phe Val Asp Asn Tyr 
    50                  55                  60                  


Phe Lys Asn Glu Leu Ala Leu Ser Asp Tyr Arg Asp Arg Ile Asp Phe 
65                  70                  75                  80  


Leu Lys Gln Tyr Phe Pro Val Val Gln Tyr Leu Glu Leu Leu Val Ser 
                85                  90                  95      


Lys Asn Asn Asp Leu Glu Lys Cys Ile Gly Glu Glu Lys Glu Asn Lys 
            100                 105                 110         


Arg Arg Glu Cys Phe Arg Ala Lys Phe Lys Ser Leu Ile Arg Thr Ile 
        115                 120                 125             


Asn Glu Leu Arg Asn Tyr Tyr Thr His His Tyr His Lys Pro Ile Ile 
    130                 135                 140                 


Val Asp Glu Ala Thr Phe Glu Leu Leu Asp Glu Leu Phe Leu Thr Val 
145                 150                 155                 160 


Val Lys Glu Val Lys Arg Tyr Lys Met Lys Gly Glu Pro Ile Arg His 
                165                 170                 175     


Leu Phe Lys Lys Glu Leu Asn Asn Glu Leu Thr Ala Leu Ile Lys Leu 
            180                 185                 190         


Lys Lys Ser Glu Leu Glu Thr Arg Arg Lys Glu Gly Lys Arg Val Asn 
        195                 200                 205             


Ile Asp Pro Val Ser Ile Glu Asn Ala Val Leu Asn Asp Ala Phe Ser 
    210                 215                 220                 


His Leu Leu Phe Gly Glu Lys Gly Glu Lys Phe Tyr Gln Ser Lys Ser 
225                 230                 235                 240 


Thr Ser Ser Asn Gln Gln Ser Thr Ile Asn Ile Ser Glu Ser Gly Leu 
                245                 250                 255     


Leu Phe Leu Leu Gly Met Phe Leu His Arg Lys Glu Ser Glu Arg Leu 
            260                 265                 270         


Arg Ser Asn Ile Gln Gly Phe Lys Ala Lys Val Val Arg Asp Pro Glu 
        275                 280                 285             


Lys Pro Ile Asp Phe Lys Asn Asn Ser Leu Lys Tyr Met Ala Thr His 
    290                 295                 300                 


Trp Val Phe Asn His Leu Ala Ala Lys Pro Ile Lys Glu Arg Leu Asn 
305                 310                 315                 320 


Thr Ala Phe Gln Lys Glu Thr Leu Leu Leu Gln Ile Ala Asp Glu Leu 
                325                 330                 335     


Ser Lys Val Pro Asp Glu Val Tyr Gln Thr Phe Ser Gln Glu Lys Lys 
            340                 345                 350         


Asn Glu Phe Leu Glu Asp Ile Asn Glu Tyr Phe Lys Thr Gly Asn Asp 
        355                 360                 365             


Ile Lys Ser Phe Glu Glu Ser Arg Val Val His Pro Val Ile Arg Lys 
    370                 375                 380                 


Arg Tyr Glu Asn Lys Phe Asn Tyr Phe Val Leu Arg Phe Leu Asp Glu 
385                 390                 395                 400 


Phe Ile Asp Phe Pro Thr Leu Arg Phe Gln Ile His Leu Gly Asn Tyr 
                405                 410                 415     


Val His Asp Gln Lys Glu Lys Pro Ile Ser Gln Gly Thr His Leu Ile 
            420                 425                 430         


Thr Gln Arg Ile Ile Lys Glu Lys Ile Asn Leu Phe Gly Lys Leu Ser 
        435                 440                 445             


Glu Val Thr Asn Asn Lys Thr Asp Phe Phe Gln Lys Leu Glu Val Ala 
    450                 455                 460                 


Gly Gly Glu Thr Asn Leu Glu Met Phe Pro Glu Pro Ser Tyr Asn Phe 
465                 470                 475                 480 


Val Gly Asn Asn Ile Pro Ile Tyr Leu Asn Leu Ala Lys Ser Lys Val 
                485                 490                 495     


Glu Gly Ala Lys Glu Leu Asn Ser His Leu Ile Arg Leu Asn Asn Glu 
            500                 505                 510         


Glu Lys Lys His Gln Lys Lys Arg Thr Gly Asn Lys Pro Asp Lys Thr 
        515                 520                 525             


Ala Ile Leu Ser Glu Ile Gln Ile Ser Asp Ile Ser Tyr Gly Lys Pro 
    530                 535                 540                 


Val Ala Leu Leu Ser Leu Asn Glu Leu Pro Ala Leu Leu Tyr Glu Leu 
545                 550                 555                 560 


Leu Ile Asn Gly Lys Ser Gly Glu Glu Ile Glu Asn Ile Leu Val Glu 
                565                 570                 575     


Lys Leu Val Glu Arg Tyr Lys Thr Ile Asn Asn Phe Ser Pro Asp Asn 
            580                 585                 590         


Pro Leu Pro Thr Ser Gln Ile Ser Lys Lys Leu Arg Lys Ala Thr Ala 
        595                 600                 605             


Asn Glu Arg Ile Asp Ile Asp Lys Leu Ile Arg Ala Ile Asp Arg Glu 
    610                 615                 620                 


Ile Ala Val Ser Lys Glu Lys Ala Asn Leu Ile Ser Thr Lys Leu Arg 
625                 630                 635                 640 


Asp Trp Glu Asn Ala Lys Thr Asn Arg Lys Tyr Ala Phe Thr Lys Lys 
                645                 650                 655     


Glu Leu Gly Gln Glu Ala Thr Trp Leu Ala Asp Asp Ile Lys Arg Phe 
            660                 665                 670         


Met Pro Asn Lys Val Lys Glu Asn Trp Lys Gly Tyr Gln His Ser His 
        675                 680                 685             


Leu Gln Leu Leu Leu Ala Phe Tyr Glu Ser Arg Pro Asn Glu Ala Tyr 
    690                 695                 700                 


Ser Phe Ile Gln Glu Phe Trp Asn Leu Asp Asn Asp Thr Tyr Leu Phe 
705                 710                 715                 720 


Asn Arg Trp Leu Lys Thr Ser Phe Asn Glu Lys Ser Phe His Lys Phe 
                725                 730                 735     


Tyr Leu Lys Tyr Leu Glu Asn Arg Lys Lys Tyr Phe Glu Asn Ile Arg 
            740                 745                 750         


His Gln Ile Thr Ala Phe Lys Asn Gln Glu Lys Leu Leu Lys Lys Phe 
        755                 760                 765             


Ile Glu Gln Gln His Ile Trp Ser Val Phe Tyr Lys Arg Leu Tyr Ile 
    770                 775                 780                 


Val Ser Pro Ile Glu Glu Gln Lys Arg Gln Leu Leu Leu Lys Pro Leu 
785                 790                 795                 800 


Val Phe Thr Arg Gly Ile Phe Asp Pro Lys Pro Thr Tyr Ile Glu Gly 
                805                 810                 815     


Lys Glu Phe Glu Gly Asn Lys Asp Leu Phe Ala Asp Trp Tyr Gln Tyr 
            820                 825                 830         


Ile His Asp Glu Glu His Val Leu Gln Lys Phe Tyr Ser Trp Lys Arg 
        835                 840                 845             


Asp Tyr Lys Glu Leu Phe Glu Lys Phe Lys Ala Ser Asp Glu Phe Thr 
    850                 855                 860                 


Asn Asn Lys Tyr Gln Leu Ser Glu Lys Gln Gln Phe Glu Leu Phe Asn 
865                 870                 875                 880 


Arg Lys Trp Asp Lys Lys Ile Arg Lys Ile Ile Gly Gln Asp Leu Phe 
                885                 890                 895     


Leu Asn Leu Ile Ile Lys Arg Ile Ile Lys Glu Leu Tyr His Gln Asp 
            900                 905                 910         


Val Ala Leu Asn Leu Ala Asp Tyr Tyr Leu Thr Gln Glu Glu Arg Ile 
        915                 920                 925             


Glu Lys Glu Gln Arg Ala Lys Gln Gln Thr Asn Arg Leu Lys Gly Asp 
    930                 935                 940                 


Lys Ser Glu Asn Ile Ile Asn Asp Ser Phe Ile Trp Asn Met Thr Ile 
945                 950                 955                 960 


Ser Tyr Lys Thr Asp Tyr Ile Asn Glu Pro Ala Ile Lys Leu Lys Asp 
                965                 970                 975     


Ile Gly Lys Phe Ile Arg Phe Leu Asn Asp Glu Lys Val Glu Arg Ile 
            980                 985                 990         


Phe Ser Tyr Thr Pro Lys Lys Asn  Asn Trp Arg Lys His  Glu Ile Glu 
        995                 1000                 1005             


Lys Glu  Leu Glu Met Tyr Glu  Lys Ile Arg Arg Glu  Glu Val Phe 
    1010                 1015                 1020             


Lys Met  Ile Gln Glu Leu Glu  Lys Lys Ile Leu Glu  Lys His Lys 
    1025                 1030                 1035             


Phe Asp  Gly Ile Asn His Pro  Asp Glu Phe Glu Lys  Ser Gly Asn 
    1040                 1045                 1050             


Pro Asn  Phe Lys Lys Tyr Ile  Ala Gln Gly Val Leu  Lys Lys His 
    1055                 1060                 1065             


Gly Ile  Gln Asp Val Val Ile  Glu Trp Ile Glu Asn  Leu Gly Glu 
    1070                 1075                 1080             


Asn Ser  Tyr Glu Asp Asn Asn  Thr Leu Glu Leu Leu  Val Gln Lys 
    1085                 1090                 1095             


Asp Glu  Lys Val Gln Asp Ala  Phe Leu Leu Ile Tyr  Leu Arg Asn 
    1100                 1105                 1110             


Lys Phe  Ala His Asn Gln Leu  Pro Thr Lys Glu Ile  Phe Asp Ile 
    1115                 1120                 1125             


Ile Val  Ser Lys Thr Asp Thr  Lys Ser Tyr Val Ala  Glu Thr Leu 
    1130                 1135                 1140             


Leu Asn  Tyr Ile Ser Ile Thr  Ser Arg Arg Ile Leu  Asn 
    1145                 1150                 1155     


<210>  2076
<211>  1156
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2076

Met Glu Asn His Thr Lys Gln Thr Thr Tyr Lys Tyr Asp Glu Ile Ala 
1               5                   10                  15      


Asp Lys His Tyr Phe Ala Gly Phe Phe Asn Leu Ala Trp Asn Asn Ile 
            20                  25                  30          


Glu Ile Val Phe Lys Val Phe Leu Lys Lys Phe Lys Leu Ile Glu Asp 
        35                  40                  45              


Lys Asp Lys Lys Ile Glu Val Asn Pro Leu Ser Phe Val Asp Asn Tyr 
    50                  55                  60                  


Phe Lys Asn Glu Leu Ala Leu Ser Asp Tyr Arg Asp Arg Ile Asp Phe 
65                  70                  75                  80  


Leu Lys Gln Tyr Phe Pro Val Val Gln Tyr Leu Glu Leu Leu Val Ser 
                85                  90                  95      


Lys Asn Asn Asp Leu Glu Lys Cys Ile Gly Glu Glu Lys Glu Asn Lys 
            100                 105                 110         


Arg Arg Glu Cys Phe Arg Ala Lys Phe Lys Ser Leu Ile Arg Thr Ile 
        115                 120                 125             


Asn Glu Leu Arg Asn Tyr Tyr Thr His His Tyr His Lys Pro Ile Ile 
    130                 135                 140                 


Val Asp Glu Ala Thr Phe Glu Leu Leu Asp Glu Leu Phe Leu Thr Val 
145                 150                 155                 160 


Val Lys Glu Val Lys Arg Tyr Lys Met Lys Gly Glu Pro Ile Arg His 
                165                 170                 175     


Leu Phe Lys Lys Glu Leu Asn Asn Glu Leu Thr Ala Leu Ile Lys Leu 
            180                 185                 190         


Lys Lys Ser Glu Leu Glu Thr Arg Arg Lys Glu Gly Lys Arg Val Asn 
        195                 200                 205             


Ile Asp Pro Val Ser Ile Glu Asn Ala Val Leu Asn Asp Ala Phe Ser 
    210                 215                 220                 


His Leu Leu Phe Gly Glu Lys Gly Glu Lys Phe Tyr Gln Ser Lys Ser 
225                 230                 235                 240 


Thr Ser Ser Asn Gln Gln Ser Thr Ile Asn Ile Ser Glu Ser Gly Leu 
                245                 250                 255     


Leu Phe Leu Leu Gly Met Phe Leu His Arg Lys Glu Ser Glu Arg Leu 
            260                 265                 270         


Arg Ser Asn Ile Gln Gly Phe Lys Ala Lys Val Val Arg Asp Pro Glu 
        275                 280                 285             


Lys Pro Ile Asp Phe Lys Asn Asn Ser Leu Lys Tyr Met Ala Thr His 
    290                 295                 300                 


Trp Val Phe Asn His Leu Ala Ala Lys Pro Ile Lys Glu Arg Leu Asn 
305                 310                 315                 320 


Thr Ala Phe Gln Lys Glu Thr Leu Leu Leu Gln Ile Ala Asp Glu Leu 
                325                 330                 335     


Ser Lys Val Pro Asp Glu Val Tyr Gln Thr Phe Ser Gln Glu Lys Lys 
            340                 345                 350         


Asn Glu Phe Leu Glu Asp Ile Asn Glu Tyr Phe Lys Thr Gly Asn Asp 
        355                 360                 365             


Ile Lys Ser Phe Glu Glu Ser Arg Val Val His Pro Val Ile Arg Lys 
    370                 375                 380                 


Arg Tyr Glu Asn Lys Phe Asn Tyr Phe Val Leu Arg Phe Leu Asp Glu 
385                 390                 395                 400 


Phe Ile Asp Phe Pro Thr Leu Arg Phe Gln Ile His Leu Gly Asn Tyr 
                405                 410                 415     


Val His Asp Gln Lys Glu Lys Pro Ile Ser Gln Gly Thr His Leu Ile 
            420                 425                 430         


Thr Gln Arg Ile Ile Lys Glu Lys Ile Asn Leu Phe Gly Lys Leu Ser 
        435                 440                 445             


Glu Val Thr Asn Asn Lys Thr Asp Phe Phe Gln Lys Leu Glu Val Ala 
    450                 455                 460                 


Gly Gly Glu Thr Asn Leu Glu Met Phe Pro Glu Pro Ser Tyr Asn Phe 
465                 470                 475                 480 


Val Gly Asn Asn Ile Pro Ile Tyr Leu Asn Leu Ala Lys Ser Lys Val 
                485                 490                 495     


Glu Gly Ala Lys Glu Leu Asn Ser His Leu Ile Arg Leu Asn Asn Glu 
            500                 505                 510         


Glu Lys Lys His Gln Lys Lys Arg Thr Gly Asn Lys Pro Asp Lys Thr 
        515                 520                 525             


Ala Ile Leu Ser Glu Ile Gln Ile Ser Asp Ile Ser Tyr Gly Lys Pro 
    530                 535                 540                 


Val Ala Leu Leu Ser Leu Asn Glu Leu Pro Ala Leu Leu Tyr Glu Leu 
545                 550                 555                 560 


Leu Ile Asn Gly Lys Ser Gly Glu Glu Ile Glu Asn Ile Leu Val Glu 
                565                 570                 575     


Lys Leu Val Glu Arg Tyr Lys Thr Ile Asn Asn Phe Ser Pro Asp Asn 
            580                 585                 590         


Pro Leu Pro Thr Ser Gln Ile Ser Lys Lys Leu Arg Lys Ala Thr Ala 
        595                 600                 605             


Asn Glu Arg Ile Asp Ile Asp Lys Leu Ile Arg Ala Ile Asp Arg Glu 
    610                 615                 620                 


Ile Ala Val Ser Lys Glu Lys Ala Asn Leu Ile Ser Thr Lys Leu Arg 
625                 630                 635                 640 


Asp Trp Glu Asn Ala Lys Thr Asn Arg Lys Tyr Ala Phe Thr Lys Lys 
                645                 650                 655     


Glu Leu Gly Gln Glu Ala Thr Trp Leu Ala Asp Asp Ile Lys Arg Phe 
            660                 665                 670         


Met Pro Asn Lys Val Lys Glu Asn Trp Lys Gly Tyr Gln His Ser His 
        675                 680                 685             


Leu Gln Leu Leu Leu Ala Phe Tyr Glu Ser Arg Pro Asn Glu Ala Tyr 
    690                 695                 700                 


Ser Phe Ile Gln Glu Phe Trp Asn Leu Asp Asn Asp Thr Tyr Leu Phe 
705                 710                 715                 720 


Asn Arg Trp Leu Lys Thr Ser Phe Asn Glu Lys Ser Phe His Lys Phe 
                725                 730                 735     


Tyr Leu Lys Tyr Leu Glu Asn Arg Lys Lys Tyr Phe Glu Asn Ile Arg 
            740                 745                 750         


His Gln Ile Thr Ala Phe Lys Asn Gln Glu Lys Leu Leu Lys Lys Phe 
        755                 760                 765             


Ile Glu Gln Gln His Ile Trp Ser Val Phe Tyr Lys Arg Leu Tyr Ile 
    770                 775                 780                 


Val Ser Pro Ile Glu Glu Gln Lys Arg Gln Leu Leu Leu Lys Pro Leu 
785                 790                 795                 800 


Val Phe Thr Arg Gly Ile Phe Asp Pro Lys Pro Thr Tyr Ile Glu Gly 
                805                 810                 815     


Lys Glu Phe Glu Gly Asn Lys Asp Leu Phe Ala Asp Trp Tyr Gln Tyr 
            820                 825                 830         


Ile His Asp Glu Glu His Val Leu Gln Lys Phe Tyr Ser Trp Lys Arg 
        835                 840                 845             


Asp Tyr Lys Glu Leu Phe Glu Lys Phe Lys Ala Ser Asp Glu Phe Thr 
    850                 855                 860                 


Asn Asn Lys Tyr Gln Leu Ser Glu Lys Gln Gln Phe Glu Leu Phe Asn 
865                 870                 875                 880 


Arg Lys Trp Asp Lys Lys Ile Arg Lys Ile Ile Gly Gln Asp Leu Phe 
                885                 890                 895     


Leu Asn Leu Ile Ile Lys Arg Ile Ile Lys Glu Leu Tyr His Gln Asp 
            900                 905                 910         


Val Ala Leu Asn Leu Ala Asp Tyr Tyr Leu Thr Gln Glu Glu Arg Ile 
        915                 920                 925             


Glu Lys Glu Gln Arg Ala Lys Gln Gln Thr Asn Arg Leu Lys Gly Asp 
    930                 935                 940                 


Lys Ser Glu Asn Ile Ile Asn Asp Ser Phe Ile Trp Asn Met Thr Ile 
945                 950                 955                 960 


Ser Tyr Lys Thr Asp Tyr Ile Asn Glu Pro Ala Ile Lys Leu Lys Asp 
                965                 970                 975     


Ile Gly Lys Phe Ile Arg Phe Leu Asn Asp Glu Lys Val Glu Arg Ile 
            980                 985                 990         


Phe Ser Tyr Thr Pro Lys Lys Asn  Asn Trp Arg Lys His  Glu Ile Glu 
        995                 1000                 1005             


Lys Glu  Leu Glu Met Tyr Glu  Lys Ile Arg Arg Glu  Glu Val Phe 
    1010                 1015                 1020             


Lys Met  Ile Gln Glu Leu Glu  Lys Lys Ile Leu Glu  Lys His Lys 
    1025                 1030                 1035             


Phe Asp  Gly Ile Asn His Pro  Asp Glu Phe Glu Lys  Ser Gly Asn 
    1040                 1045                 1050             


Pro Asn  Phe Lys Lys Tyr Ile  Ala Gln Gly Val Leu  Lys Lys His 
    1055                 1060                 1065             


Gly Ile  Gln Asp Val Val Ile  Glu Trp Ile Glu Asn  Leu Gly Glu 
    1070                 1075                 1080             


Asn Ser  Tyr Glu Asp Asn Asn  Thr Leu Glu Leu Leu  Val Gln Lys 
    1085                 1090                 1095             


Asp Glu  Lys Val Gln Asp Ala  Phe Leu Leu Ile Tyr  Leu Arg Asn 
    1100                 1105                 1110             


Lys Phe  Ala His Asn Gln Leu  Pro Thr Lys Glu Ile  Phe Asp Ile 
    1115                 1120                 1125             


Ile Val  Ser Lys Thr Asp Thr  Lys Ser Tyr Val Ala  Glu Thr Leu 
    1130                 1135                 1140             


Leu Asn  Tyr Ile Ser Ile Thr  Ser Arg Arg Ile Leu  Asn 
    1145                 1150                 1155     


<210>  2077
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2077

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2078
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2078

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2079
<211>  1124
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2079

Met Asn Ile Glu Ile Lys Ala Arg Asn Met Ser Asp His Pro Gln Tyr 
1               5                   10                  15      


Phe Gly Ala Phe Leu Asn Met Ala Arg Leu Asn Ile Phe Ser Ile Ser 
            20                  25                  30          


Asn His Leu Ala Lys Ile Phe Asp Lys Thr Pro Leu Asp Asp Glu Glu 
        35                  40                  45              


Lys Ile Leu Thr Ser Phe Ile Ser Asp Lys Lys Ile Lys Asn Leu Asn 
    50                  55                  60                  


Trp Asn Lys Val Ile Gly Ile Leu Lys Lys Phe Met Pro Ile Val Lys 
65                  70                  75                  80  


Ile Val Asn Ala Glu Thr Leu Pro Lys Ser Glu Gln Glu Lys Leu Lys 
                85                  90                  95      


Asp Glu Asn Lys Phe Asn Pro Lys Asn Asp Phe Glu Lys Met Cys Asp 
            100                 105                 110         


Phe Leu Phe Tyr Leu Phe Lys Glu Ile Ser Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Thr His Tyr Tyr Ser Ile Glu Asn Lys Thr Glu Arg Lys Lys Asn Val 
    130                 135                 140                 


Ser Pro Glu Ile Lys Asp Phe Leu Ile Glu Asn Phe Asn Arg Ala Val 
145                 150                 155                 160 


Glu Tyr Thr Lys Asp Arg Phe Ala Asn Val Phe Thr Asp Lys Asp Phe 
                165                 170                 175     


Glu Leu Ala Lys Asn Ile Val Leu Phe Asn Asp Asn Ser Glu Ile Thr 
            180                 185                 190         


Ser Leu Gly Leu Ala Phe Leu Ile Ser Ile Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Leu Phe Ile Gly Lys Val Thr Gly Leu Lys Gly Thr Gln His 
    210                 215                 220                 


Lys Ser Phe Leu Ala Val Arg Glu Ile Phe Met Ala Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Leu Val Ser Glu Asp Arg Lys Gln Glu Leu Ser 
                245                 250                 255     


Leu Leu Ile Ile Ser Glu Leu Asn Lys Cys Pro Gln Glu Leu Tyr Asn 
            260                 265                 270         


Val Ile Ser Asp Asp Glu Lys Lys Tyr Phe Leu Pro Glu Leu Asp Val 
        275                 280                 285             


Ile Ala Lys Ala Asn Val Leu Glu Asn Ser Val Pro Asp Asp Glu Met 
    290                 295                 300                 


Asp Tyr Asp Asn Tyr Ile Gln Asn Ile Thr Lys Lys Ile Arg Tyr Glu 
305                 310                 315                 320 


Asn Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Ile Asp Glu Thr Asn Phe 
                325                 330                 335     


Phe Thr Lys Tyr Arg Phe Gln Ile Asn Leu Gly Lys Val Leu Leu Asn 
            340                 345                 350         


Glu Tyr Lys Lys Lys Leu Leu Asn Glu Glu Glu Asp Arg Gln Ile Ile 
        355                 360                 365             


Asp Lys Ala Phe Ala Phe Gly Lys Leu Asn Leu Phe Leu Asn Asn Glu 
    370                 375                 380                 


Asp Glu Ile Leu Lys Lys Ile Asn Lys Ala Asn Gly Asn Ile Glu Phe 
385                 390                 395                 400 


Glu Gln Phe Ala Pro His Tyr Asn Phe Asn Asp Gln Leu Phe Lys Ile 
                405                 410                 415     


Gly Ile Ser Asn Lys Glu Ser Tyr Pro Ile Phe Ile Lys Asn Glu Asn 
            420                 425                 430         


Lys Ala Asn Gly Ile Leu Lys Gln Thr Leu Pro Asp Ala Phe Leu Ser 
        435                 440                 445             


Leu Asn Ile Leu Ser Asp Ile Ile Leu Leu Asp Tyr Leu Lys Lys Gly 
    450                 455                 460                 


Glu Ser Glu Lys Leu Ile Ala Asp Phe Ile Gln Leu Asn Lys Ser His 
465                 470                 475                 480 


Ile Leu Asn Trp Glu Phe Ile Glu Lys Ile Lys Ala Lys Phe Ala Gly 
                485                 490                 495     


Leu Glu Val Phe Gln Lys Tyr Ser Arg Gly Lys Lys Gln Pro Ala Ala 
            500                 505                 510         


Tyr Arg Thr Glu Arg Leu Lys Glu Leu Glu Asp Arg Lys Lys Arg Leu 
        515                 520                 525             


Asn Asp Val Leu Thr Glu Tyr Asn Leu Asn Asp Lys Gln Ile Pro Ser 
    530                 535                 540                 


Arg Ile Ile Glu Tyr Trp Leu Asn Ile Asn Asp Thr Ala Lys Asn Lys 
545                 550                 555                 560 


Gln Ile Ser Asp Lys Ile Lys Leu Met Lys Asn Asp Gly Lys Asp Arg 
                565                 570                 575     


Leu Lys Asp Leu Arg Lys Asn Lys Ala Pro Lys Ile Gly Glu Met Ala 
            580                 585                 590         


Thr Phe Leu Ala Lys Asp Ile Val Asp Met Ile Ile Ser Lys Glu Arg 
        595                 600                 605             


Lys Val Lys Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Gly Leu 
    610                 615                 620                 


Ala Leu Tyr Asn Val Glu Glu Lys Arg Lys Met Phe Leu Asp Ile Cys 
625                 630                 635                 640 


Asn Leu Pro Glu Ile Asn Leu Phe Asp Pro Gln Ala Gly His Pro Phe 
                645                 650                 655     


Leu Ser Lys Ile Asn Pro Ala Lys Ile Lys Tyr Thr Thr Asp Phe Tyr 
            660                 665                 670         


Arg Leu Tyr Leu Glu Glu Lys Thr Cys Lys Met Val Glu Thr Thr Asn 
        675                 680                 685             


Tyr Lys Thr Gly Lys Ile Ser Lys Lys Asp Gln Ser Trp Met Ser Asn 
    690                 695                 700                 


Thr Phe Tyr Lys Leu Glu Tyr Ser Glu Lys Val Gly Lys Asn Met Thr 
705                 710                 715                 720 


Val Val Lys Leu Pro Ser Ile Ile Ser Asn Leu Pro Leu Thr Ile Gln 
                725                 730                 735     


Lys Trp Cys Lys Glu Asn Tyr Asp Phe Lys Glu Trp Phe Asp His Ile 
            740                 745                 750         


His Gly Lys Ile Asp Asn Ala Pro Lys Pro Val Ala Lys Pro Val Asp 
        755                 760                 765             


Leu Pro Thr Asn Leu Phe Glu Pro Ala Ile Lys His Glu Leu Gln Asp 
    770                 775                 780                 


Ile Phe Lys Asn His Ile Pro Phe Asn Asp Asn Asp Thr Asn Asn Gln 
785                 790                 795                 800 


Leu Phe Lys Leu Trp Trp Thr Lys Val Lys Asn Asn Gly Phe Met Lys 
                805                 810                 815     


Phe Tyr Asn Thr Lys Arg Glu Tyr Asn Ile Tyr Asp Glu Lys Val Ile 
            820                 825                 830         


Phe Glu Ile Lys Pro Gln Gly Lys Phe Ser Asp Tyr Tyr Gln Asn Ala 
        835                 840                 845             


Leu Ser Lys Ala Phe Lys Asn Leu Ser Thr Glu Arg Lys Asn Glu Lys 
    850                 855                 860                 


Gln Ile Asn Arg Ala Leu Pro Asp Ile Asp Arg Lys Gln Val Glu Lys 
865                 870                 875                 880 


Val Phe Lys Gln Thr Ile Gly Asn Thr Glu Lys Lys Ile Arg Ile Leu 
                885                 890                 895     


Gln Glu Glu Asp Ala Leu Met Leu Leu Met Phe Glu Lys Leu Leu Asp 
            900                 905                 910         


Met Pro Gly Ile Asn Met Leu Asn Asn Ile Asn Met Asp Asn Ile Leu 
        915                 920                 925             


Asp Glu Thr Ile Glu Val Lys Gln Lys Ile Glu Arg Lys Leu Ser Phe 
    930                 935                 940                 


Asp Asp Asn Gly Glu Ile Ile Lys Asn Asp Asp Ala Lys Lys Thr Ile 
945                 950                 955                 960 


Ser Lys Ile Ile Val Glu Glu Arg Lys Arg Lys Glu Tyr Ser Val Leu 
                965                 970                 975     


His Lys Tyr Leu Tyr Asp Lys Arg Leu Pro Glu Leu Phe Glu Tyr Phe 
            980                 985                 990         


Glu Glu Pro Glu Ile Pro Val Ala  Lys Leu Lys Leu Glu  Leu Asp Asn 
        995                 1000                 1005             


Tyr Asn  Gln Ala Lys Asn Glu  Ile Phe Asp Leu Val  Phe Asn Phe 
    1010                 1015                 1020             


Glu Lys  Lys Leu Ile Glu Lys  Asp Lys Asp Gly Ile  Ile Ala Lys 
    1025                 1030                 1035             


Ile Glu  Thr Lys Pro Asp Glu  Val Pro Thr Gly Asn  Ile Gln His 
    1040                 1045                 1050             


Lys Pro  Tyr Leu Leu Trp Leu  Lys Ser Lys Asn Tyr  Ile Asp Asp 
    1055                 1060                 1065             


Ser Asp  Phe Lys Phe Leu Asn  Met Val Arg Asn Thr  Phe Ser His 
    1070                 1075                 1080             


Asn Gln  Phe Pro Gln Lys Lys  Thr Met Glu Ile Phe  Ile Asn Thr 
    1085                 1090                 1095             


Trp Asn  Lys Thr Lys Phe Ala  Glu Asn Ile Phe Glu  Ile Tyr Lys 
    1100                 1105                 1110             


Leu Lys  Ile Glu Phe Ile Leu  Gly Lys Val Gly 
    1115                 1120                 


<210>  2080
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2080

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe His Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Arg Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Met Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2081
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2081

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2082
<211>  1262
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2082

Leu Gln Asn Ala Lys Tyr Ile Arg Asn Phe Ala Lys Arg Arg Pro Asn 
1               5                   10                  15      


Asn Tyr Tyr Ser Lys Gln Ser Val Lys Gln Lys Tyr Met Ile Ile Lys 
            20                  25                  30          


Glu Ser Lys Gln Arg Lys Asp Lys Val Arg Thr Gln Thr Glu Asp Ser 
        35                  40                  45              


Gln Leu Ser His Asn Arg Arg Ser Pro Lys Ala Gln Met Pro Tyr Thr 
    50                  55                  60                  


Glu Asn Asp Lys Leu Arg Ser Val Tyr Ala Ala Tyr Leu Asn Met Ala 
65                  70                  75                  80  


Arg Met Asn Leu Tyr Asn Thr Leu Arg Phe Ile Gly His Leu Tyr Gly 
                85                  90                  95      


Met Asp Asp Asn Ile Gln Glu Gly Glu Met Asp Lys Met Lys Val Ala 
            100                 105                 110         


Asn Phe Ala Asn His Pro His Leu Glu Lys Arg Leu Ser Val Arg Lys 
        115                 120                 125             


Ala Leu Leu Lys His Leu Pro Phe Leu His Cys Met Ala Gln Ala Tyr 
    130                 135                 140                 


Val Asn Thr Glu His Lys Tyr Thr Asp Asp Asn Asp Leu Gln Lys Val 
145                 150                 155                 160 


Leu Leu Asn Ile Ile Asn Val Val Ser Asn Gln Arg Asp His Leu Thr 
                165                 170                 175     


His Ala Asn Pro Tyr Asn Asn Asp Ala Asp Trp Ala Lys Gln Lys Glu 
            180                 185                 190         


Ile Glu Lys Gln Leu Leu Glu Pro Leu Glu Lys Ala Phe Met Phe Ser 
        195                 200                 205             


Lys His Lys Val Glu Thr Ile Phe Asp Tyr Ser Lys Ser Asp Met Ser 
    210                 215                 220                 


Phe Ile Asp Arg Leu Glu Arg Met Met Asp Thr Gly Asp Thr Ile Ile 
225                 230                 235                 240 


Val Lys Glu Asn Asn Lys Glu Arg Glu Leu Arg Asp Asn Gln Asp His 
                245                 250                 255     


Ser Asp Tyr Tyr Phe Arg Leu Arg Thr Pro Glu Gly Asp Ala Leu Ser 
            260                 265                 270         


Thr Val Gly Leu Thr Phe Leu Ile Cys Lys Leu Leu His Lys Lys His 
        275                 280                 285             


Ala Thr Ile Phe Ala Gln Arg Thr Gly Leu Phe Leu Glu Gln Ser His 
    290                 295                 300                 


Leu Asp Gly Tyr Ser Pro Phe Ser Lys Arg Glu Asn Glu Ile Met Phe 
305                 310                 315                 320 


Asn Ile Phe Cys His Glu Arg Ile Arg Leu Pro Lys Gly Arg Leu Glu 
                325                 330                 335     


Ser Thr Thr Asp Pro Met Ala Leu Gly Leu Asp Met Leu Ala Glu Leu 
            340                 345                 350         


Gln Lys Cys Pro Ala Glu Leu Phe Asn Thr Phe Gly Pro Ser Asp Arg 
        355                 360                 365             


Lys Leu Phe Glu Val Arg Asn Glu Asp Phe Ser Thr Asp Ser Ser Thr 
    370                 375                 380                 


Glu Asp Ile Ile Leu Met Arg Arg Tyr Gly Asp Arg Phe Ala Arg Leu 
385                 390                 395                 400 


Ala Met Gln Tyr Ile Asp Ser Phe Asn Ala Asp Pro Asn His Arg Asn 
                405                 410                 415     


Lys Arg Asp Ser Ala Pro Leu Pro Gly Met Ala Phe Gln Val Ser Val 
            420                 425                 430         


Gly Lys Phe Arg His Thr Phe Tyr Glu Arg Ala Pro Phe His Glu Gly 
        435                 440                 445             


Val Lys Asp Arg Val Arg Val Leu Gln Lys Glu Ile Asn Gly Phe Gly 
    450                 455                 460                 


Pro Leu Thr Lys Ile Glu Asp Leu Arg Gln Thr Asp Tyr Ala Leu Phe 
465                 470                 475                 480 


Ile Arg Gln Val Asn Asp Asp Ser Ser Asp Arg Leu Tyr Asp Pro Asp 
                485                 490                 495     


Thr Ala Gln Thr Arg Pro Tyr Ile Thr Asp His His Ala Ser Tyr Ala 
            500                 505                 510         


Ile Thr Gly Asp Arg Ile Gly Leu Met Trp Asn Asp Glu Asn Val Gln 
        515                 520                 525             


Val Leu Asn Asn Asp Thr Leu Cys Tyr Leu Pro Glu Leu Pro Ile Pro 
    530                 535                 540                 


Thr Ala Thr Asp Asp Ser Lys Lys Pro Trp Asn Val Asp Leu Thr Val 
545                 550                 555                 560 


Phe Asn Arg Ser Asn Gly Gly His Pro Lys Gly Asn Ile Ala Pro Arg 
                565                 570                 575     


Ala Trp Leu Ser Ile Tyr Asp Leu Pro Ala Leu Ile Phe Leu His Phe 
            580                 585                 590         


Leu Gly Gly Lys Pro Ala Ser Val Ile Lys Asp Thr Tyr Asn Ser Leu 
        595                 600                 605             


Met Lys Leu Phe Asp Asp Ile Ala Glu Gly Arg Arg Asp Pro Tyr Phe 
    610                 615                 620                 


Lys Gly Gln Ile Pro Gln Asp Pro Asn Ser Arg Lys Lys Val Ile Leu 
625                 630                 635                 640 


Ser Leu Arg Glu Gln Leu Thr Pro His Leu Met Thr Asp Tyr Gly Leu 
                645                 650                 655     


His Thr Arg Asp Ile Pro Asp Lys Ile Val Glu Tyr Leu Ile Gly Glu 
            660                 665                 670         


Gly Leu Ala Ala Asn Glu Gln Thr Ala Ile Leu His Ala Glu Glu Arg 
        675                 680                 685             


Phe Arg Lys Trp Cys Asp Ile Lys Val Lys Ala Met Lys Lys Asp Leu 
    690                 695                 700                 


Asp Leu Arg Ile Glu His Phe Asn Lys Asp Lys Glu Gln Ile Gly Asn 
705                 710                 715                 720 


Ser Ser Asn Arg Ile Gly Ser Lys Arg Tyr Val Asp Leu Arg Pro Gly 
                725                 730                 735     


Ser Leu Ala Arg Tyr Leu Ala Lys Asp Met Ile Ala Met Val Asp Pro 
            740                 745                 750         


Lys Asp Gly Ala Lys Pro Ser Gly Leu Asp Phe Thr Leu Leu Gln Ala 
        755                 760                 765             


Ala Ile Ala Thr Tyr Gln Gly Asn Gly Cys Pro Leu Glu Lys Thr Glu 
    770                 775                 780                 


Leu Gly Ala Thr Ile Lys Lys Ala Phe Ala Trp Gln Ala His Pro Phe 
785                 790                 795                 800 


Leu Pro Lys Ile Met Asn Leu Thr Val Ser Asp Thr Ile Asp Leu Tyr 
                805                 810                 815     


Ser Arg Tyr Gln Asn Glu Lys Thr Lys Tyr Leu Asp Arg Leu Leu Gln 
            820                 825                 830         


Ser His Lys Tyr Ser Asp Thr Tyr Phe Leu Arg Asn Ala His Arg Asn 
        835                 840                 845             


Met Met Ala Lys Thr Arg Ser Tyr Met Arg Asp Gln Lys Gly Gln Asp 
    850                 855                 860                 


Gly Thr Leu Ile Glu Gly Leu Ala His Arg Tyr Arg Lys Thr Leu Gln 
865                 870                 875                 880 


Leu Pro Asp Gly Leu Phe Thr Asn Ala Ile Arg Glu Gln Leu Ala Lys 
                885                 890                 895     


Ile Asn Asn Ser Asp Ile Gln Asp Ala Leu Asn Asn Pro Gln Phe Gly 
            900                 905                 910         


His Ser Ala Ala Tyr Leu Leu Asn Leu Trp Phe Thr Lys Ile Ile Gly 
        915                 920                 925             


Asp Gln Ser Gln Pro Phe Tyr Arg Ser Asp Thr His Gly His Tyr Lys 
    930                 935                 940                 


Arg His Tyr Lys Leu Leu Glu Thr Leu Tyr Pro Gln Lys Thr Pro Leu 
945                 950                 955                 960 


Asp Asp Ala Thr Leu Ser Ala Lys Leu Lys Gly Gly Lys Asn Ser Glu 
                965                 970                 975     


Ile Lys Gln Glu Ile Asp Lys Gln Ala Pro Val Ala Lys Lys Glu Ala 
            980                 985                 990         


Glu His Gln Lys Leu Met His Leu  Leu Arg Asp Leu Gln  Arg Asn Glu 
        995                 1000                 1005             


Arg Thr  Ile Arg Arg Tyr Arg  Asn Gln Asp Met Val  Leu Phe Leu 
    1010                 1015                 1020             


Met Ala  Lys Lys Leu Leu Leu  Ser Gly Gly Ala Pro  Phe Met Asn 
    1025                 1030                 1035             


Arg Ala  Glu Ser Asp Gly Ser  Arg Gln Phe Leu Leu  Gln Asn Ile 
    1040                 1045                 1050             


Val Pro  Ile Gly Val Asn His  Gly Glu Glu Asn Asn  Leu Leu Asn 
    1055                 1060                 1065             


Gln Lys  Val Ser Leu Ser Thr  Arg Ile Thr Leu Leu  Asp Asp Lys 
    1070                 1075                 1080             


Asn Lys  Pro Ile Lys Asp Ser  Glu Lys His Pro Met  Lys Arg Thr 
    1085                 1090                 1095             


Ile His  Gln Lys Glu Ile Lys  Met Lys Asn Tyr Gly  Asp Phe Phe 
    1100                 1105                 1110             


Arg Phe  Leu Tyr Asp Ser Arg  Ile Gly Ile Leu Leu  Ser Gln Leu 
    1115                 1120                 1125             


Pro Asp  Asp Glu Ala Gly Ile  Ala Arg Glu Lys Leu  Glu Lys Glu 
    1130                 1135                 1140             


Leu Asp  Thr Tyr Asp Asn Ser  Arg Thr Asp Ile Phe  Lys Val Ile 
    1145                 1150                 1155             


His Lys  Ile Glu Arg Gln Ile  Ile Glu Glu His Pro  Glu Leu Lys 
    1160                 1165                 1170             


Asn Pro  Asn Ser Gly His Phe  Thr Asn Asp Lys Gly  Thr Pro Tyr 
    1175                 1180                 1185             


Arg Asn  Asn Phe Thr Leu Leu  Leu Thr Leu Ser Ala  Leu Phe Ser 
    1190                 1195                 1200             


Glu Ala  Asp His Asn Leu Asn  Gln Lys Gly Lys Leu  Leu Lys Asp 
    1205                 1210                 1215             


Ile Arg  Asp Ala Phe Cys His  Asn Lys Tyr Ile Glu  Asn Ile Glu 
    1220                 1225                 1230             


Arg Ala  Ile Lys Glu Lys Glu  Glu Arg Glu Leu Pro  Lys Ile Ala 
    1235                 1240                 1245             


Glu Asn  Leu Thr Lys Trp Met  Lys Glu Phe Gly Glu  Gln Ser 
    1250                 1255                 1260         


<210>  2083
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2083

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Ala Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Asn Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2084
<211>  1146
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2084

Met Glu Ser Ile Ile Gly Leu Gly Leu Ser Phe Asn Pro Tyr Lys Thr 
1               5                   10                  15      


Ala Asp Lys His Tyr Phe Gly Ser Phe Leu Asn Leu Ala Asp Asn Asn 
            20                  25                  30          


Leu Lys Ala Val Phe Ala Glu Phe Lys Glu Arg Ile Ser Asp Lys Ser 
        35                  40                  45              


Lys Asp Glu Asp Ile Ser Asn Leu Ile Glu Lys His Phe Ile Asp Asn 
    50                  55                  60                  


Met Ser Ile Val Asp Tyr Glu Lys Asn Ile Ser Ile Leu Asn Gly Tyr 
65                  70                  75                  80  


Leu Pro Ile Ile Asp Phe Leu Asp Asp Glu Leu Glu Asn Asn Leu Asn 
                85                  90                  95      


Thr Arg Val Lys Asn Phe Lys Lys Ser Phe Ile Ile Leu Ala Glu Ala 
            100                 105                 110         


Leu Glu Thr Leu Arg Asn Tyr Tyr Thr His Phe Tyr His Asp Pro Ile 
        115                 120                 125             


Thr Phe Gly Asp Asn Lys Glu Pro Leu Leu Glu Leu Leu Asp Glu Val 
    130                 135                 140                 


Leu Leu Lys Thr Ile Leu Asp Val Lys Lys Lys Tyr Leu Lys Thr Asp 
145                 150                 155                 160 


Lys Thr Lys Glu Ile Leu Lys Asp Ser Leu Arg Glu Glu Met Asp Leu 
                165                 170                 175     


Leu Val Ile Arg Lys Thr Asp Glu Leu Arg Glu Lys Lys Lys Thr Asn 
            180                 185                 190         


Pro Lys Phe Lys Phe Ser Thr Asp Pro Thr Gln Ile Arg Asn Ser Ile 
        195                 200                 205             


Phe Asn Asp Ala Phe Gln Gly Leu Leu Tyr Glu Asp Lys Glu Asn Asn 
    210                 215                 220                 


Gly Lys Thr Gln Val Ser Tyr Arg Ala Lys Thr Lys Leu Asn Pro Lys 
225                 230                 235                 240 


Asp Ile His Lys Gln Glu Glu Arg Asp Phe Glu Ile Pro Leu Ser Thr 
                245                 250                 255     


Ser Gly Ile Val Phe Leu Met Ser Leu Phe Leu Ser Lys Lys Glu Ile 
            260                 265                 270         


Glu Asp Phe Lys Ser Asn Ile Lys Gly Phe Lys Gly Lys Val Val Lys 
        275                 280                 285             


Asp Glu Asn His Asn Ser Leu Lys Tyr Met Ala Thr His Arg Val Tyr 
    290                 295                 300                 


Ser Ile Leu Ala Phe Lys Gly Leu Lys Tyr Arg Ile Lys Thr Asp Thr 
305                 310                 315                 320 


Phe Ser Lys Val Thr Leu Met Met Gln Met Ile Asp Glu Leu Ser Lys 
                325                 330                 335     


Val Pro Asp Cys Val Tyr Gln Asn Leu Ser Glu Thr Lys Gln Lys Asp 
            340                 345                 350         


Phe Ile Glu Asp Trp Asn Glu Tyr Leu Lys Asp Asn Glu Glu Asn Thr 
        355                 360                 365             


Glu Asn Leu Glu Asn Ser Arg Val Val His Pro Leu Ile Arg Lys Arg 
    370                 375                 380                 


Tyr Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe 
385                 390                 395                 400 


Ala Asn Phe Lys Thr Leu Lys Phe Gln Val Phe Met Gly Tyr Tyr Ile 
                405                 410                 415     


His Asp Gln Arg Thr Lys Thr Ile Gly Thr Thr Asn Ile Thr Thr Glu 
            420                 425                 430         


Arg Thr Val Lys Glu Lys Ile Asn Val Phe Gly Lys Leu Ser Lys Met 
        435                 440                 445             


Asp Asn Leu Lys Lys His Phe Phe Ser Gln Leu Ser Asp Glu Glu Asn 
    450                 455                 460                 


Thr Asp Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Phe Leu Thr Gln 
465                 470                 475                 480 


Ala Asp Asn Ser Pro Ala Asn Asn Ile Pro Ile Tyr Leu Glu Leu Lys 
                485                 490                 495     


Asn Gln Gln Ile Ile Lys Glu Lys Asp Asp Ile Lys Ala Glu Val Asn 
            500                 505                 510         


Asn Ser Gln Asn Arg Asn Pro Asn Lys Pro Ser Lys Arg Asp Leu Leu 
        515                 520                 525             


Asn Lys Ile Ser Asn Thr Asn Glu Asp Phe Tyr Gln Gly Asp Pro Thr 
    530                 535                 540                 


Ala Ile Leu Ser Leu Asn Glu Ile Pro Ala Leu Leu His Leu Phe Leu 
545                 550                 555                 560 


Val Gln Pro Asp Asn Lys Thr Gly Gln Gln Ile Glu Asn Ile Ile Arg 
                565                 570                 575     


Ile Lys Ile Glu Lys Gln Phe Asn Ser Ile Lys Asn Pro Ser Lys Asp 
            580                 585                 590         


Asp Lys Gly Val Pro Lys Ser Leu Phe Ala Asp Thr Asn Val Arg Val 
        595                 600                 605             


Asn Ala Ile Lys Leu Lys Lys Asp Leu Gly Glu Glu Leu Asp Met Leu 
    610                 615                 620                 


Asn Lys Lys Gln Ile Val Phe Lys Glu Asn Gln Lys Ala Ser Ser Asn 
625                 630                 635                 640 


Tyr Asp Glu Leu Leu Lys Lys His Gln Phe Thr Pro Lys Asn Lys Arg 
                645                 650                 655     


Pro Ala Leu Arg Lys Tyr Val Phe Tyr Asn Ser Glu Lys Gly Glu Glu 
            660                 665                 670         


Ala Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Lys Gly Phe 
        675                 680                 685             


Lys Thr Lys Trp Lys Gly Tyr Gln His Ser Glu Leu Gln Arg Lys Leu 
    690                 695                 700                 


Ala Phe Tyr Asp Arg His Thr Lys Gln Asp Ile Lys Glu Leu Leu Ser 
705                 710                 715                 720 


Gly Cys Glu Phe Asp His Phe Leu Leu Asp Ile Asn Ala Cys Phe Lys 
                725                 730                 735     


Glu Asp Asp Phe Glu Asp Phe Phe Ser Lys Tyr Leu Lys Asn Arg Ile 
            740                 745                 750         


Glu Thr Leu Asn Ile Ile Leu Lys Gln Leu His Asp Phe Lys Asn Glu 
        755                 760                 765             


Pro Thr Pro Leu Lys Gly Val Phe Lys Asn Cys Leu Lys Phe Leu Lys 
    770                 775                 780                 


Gln Lys Asn Tyr Val Thr Glu Asn Pro Glu Ile Ile Lys Lys Arg Ile 
785                 790                 795                 800 


Leu Ala Lys Pro Ala Phe Leu Pro Arg Gly Ile Phe Asp Glu Arg Pro 
                805                 810                 815     


Thr Met Lys Lys Gly Lys Asn Pro Leu Ile Asp Arg Asp Glu Phe Ala 
            820                 825                 830         


Lys Trp Phe Val Glu Tyr Leu Glu Asn Lys Asp Tyr Gln Lys Phe Tyr 
        835                 840                 845             


Asn Ser Glu Glu Tyr Arg Ile Arg Asp Ala Asp Phe Lys Lys Asn Ala 
    850                 855                 860                 


Val Ile Lys Lys Gln Lys Leu Lys Asp Phe Tyr Thr Leu Gln Met Val 
865                 870                 875                 880 


Asn Tyr Leu Leu Lys Glu Val Phe Gly Lys Asp Glu Met Asn Leu Gln 
                885                 890                 895     


Leu Ser Glu Leu Phe Gln Thr Arg Gln Glu Arg Leu Lys Leu Gln Gly 
            900                 905                 910         


Ile Ala Lys Lys Gln Met Asn Lys Glu Thr Gly Asp Ser Ser Glu Asn 
        915                 920                 925             


Thr Arg Asn Gln Thr Tyr Ile Trp Asn Lys Asp Val Pro Val Ser Phe 
    930                 935                 940                 


Phe Asn Gly Lys Val Thr Ile Asp Lys Val Lys Leu Lys Asn Ile Gly 
945                 950                 955                 960 


Lys Tyr Lys Arg Tyr Glu Arg Asp Glu Arg Val Lys Thr Phe Ile Gly 
                965                 970                 975     


Tyr Glu Val Asp Glu Lys Trp Met Met Tyr Leu Pro His Asn Trp Lys 
            980                 985                 990         


Asp Arg Tyr Ser Val Lys Pro Ile  Asn Val Ile Asp Leu  Gln Ile Gln 
        995                 1000                 1005             


Glu Tyr  Glu Glu Ile Arg Ser  His Glu Leu Leu Lys  Glu Ile Gln 
    1010                 1015                 1020             


Asn Leu  Glu Gln Tyr Ile Tyr  Asp His Thr Thr Asp  Lys Asn Thr 
    1025                 1030                 1035             


Leu Leu  Gln Asp Gly Asn Pro  Asn Phe Lys Met Tyr  Val Leu Asn 
    1040                 1045                 1050             


Gly Leu  Leu Thr Gly Ile Lys  Gln Val Asn Ile Ala  Asp Phe Ile 
    1055                 1060                 1065             


Val Leu  Lys Gln Asn Thr Asn  Phe Asp Lys Ile Asp  Phe Thr Gly 
    1070                 1075                 1080             


Ile Ala  Ser Cys Ser Glu Leu  Glu Lys Lys Thr Ile  Ile Leu Ile 
    1085                 1090                 1095             


Ala Ile  Arg Asn Lys Phe Ala  His Asn Gln Leu Pro  Asn Lys Thr 
    1100                 1105                 1110             


Ile Tyr  Asp Leu Ala Asn Glu  Phe Leu Lys Lys Glu  Lys Arg Glu 
    1115                 1120                 1125             


Thr Tyr  Ala Asn Tyr Tyr Leu  Lys Val Leu Lys Lys  Met Ile Ser 
    1130                 1135                 1140             


Asp Leu  Ala 
    1145     


<210>  2085
<211>  1242
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2085

Met Glu Gln Asn Arg Lys Glu Gly Ser Leu Arg Thr Gln Glu Asp Ile 
1               5                   10                  15      


Gln Tyr Phe Gly Ser Tyr Phe Asn Met Ala Arg His Asn Leu Tyr Leu 
            20                  25                  30          


Ile Thr Asn His Leu Thr Ser Val Phe Ser His Leu Asn Phe Ser Gln 
        35                  40                  45              


Leu Asp Asp Asp Glu Asp Ile Trp Ser Asp Lys Pro Glu Val Asn Glu 
    50                  55                  60                  


Lys Asn Ile Leu Leu Asn Ile Phe Asp Thr Lys Asn Glu Arg Leu Gln 
65                  70                  75                  80  


Asp Glu Arg Ile Arg Val Phe Arg Tyr Leu Met Arg Arg His His Leu 
                85                  90                  95      


Pro Cys Leu Arg Ile Phe Thr Asn Asp Phe Lys Val Leu Glu Thr Thr 
            100                 105                 110         


Gly Asn Thr Ile Lys Lys Asp Glu Leu Glu Val Asp Phe Asp Ala Val 
        115                 120                 125             


His Lys Phe Leu Asn Ile Ala Phe Lys Glu Ile Asn Leu Phe Arg Asn 
    130                 135                 140                 


Ser Tyr Thr His Tyr Leu Ser Ile Asn Glu Glu Gly Lys Arg Leu Lys 
145                 150                 155                 160 


Lys Lys Lys Lys Ile Ser Ser Lys Leu Val Pro Val Leu Asn Ser Leu 
                165                 170                 175     


Phe Ser Tyr Ala Pro Glu Tyr Ser Phe Leu Arg His Asn Ile Asp Lys 
            180                 185                 190         


Ala Asn Lys Asp Val Lys Ile Tyr Lys Glu Glu Val Lys Glu Tyr Tyr 
        195                 200                 205             


Asp Asn Ile Lys Ser Lys Tyr Lys Leu Phe Glu Asn Asp Ser Asn Glu 
    210                 215                 220                 


Leu Thr Asp Gln Gly Met Tyr Phe Phe Ile Thr Leu Phe Leu Glu Arg 
225                 230                 235                 240 


Ala His Gly Ile Lys Phe Leu Lys Arg Phe Arg Gly Phe Lys Asn Glu 
                245                 250                 255     


Thr Thr Pro Pro Phe Lys Ala Thr Ile Gln Ala Phe Thr Thr Tyr Thr 
            260                 265                 270         


Leu Lys Ile Pro Asp Val Arg Leu Asp Asn Asp Ile Pro Glu Gln Thr 
        275                 280                 285             


Met Ile Met Glu Val Leu Asn Glu Leu Asn Lys Cys Pro Glu Glu Leu 
    290                 295                 300                 


Phe Lys Phe Leu Lys Lys Glu Asp Lys Asp Arg Phe Gln Pro Val Ile 
305                 310                 315                 320 


Ser Asp Glu Ser Leu Thr Asn Ile Ile Asn Ser Ser Asn Tyr Glu Glu 
                325                 330                 335     


Ile Ser Asp Glu Asp Ile Asp Arg Leu Ile Lys Glu Asn Ser Val Leu 
            340                 345                 350         


Lys Arg Arg Glu Asp Arg Phe Pro Tyr Phe Ala Leu Gln Tyr Leu Glu 
        355                 360                 365             


Ile Met Ser Lys Leu Lys Asn Ile Arg Phe Gln Ile Tyr Leu Gly Lys 
    370                 375                 380                 


Leu Val Leu Lys Thr Tyr Asp Lys Glu Asn Pro Asn Ile Glu Arg Arg 
385                 390                 395                 400 


Val Ile Thr Asp Ile His Ala Phe Gly Lys Leu Ser Asp Phe Val Gly 
                405                 410                 415     


Lys Glu Ala Glu Val Leu Asp Thr Phe Asn Ser Gln Leu Lys Asp Tyr 
            420                 425                 430         


Gly Tyr Ser Val Ala Trp Asp Gln Tyr Lys Pro Ser Tyr Ala Ile Glu 
        435                 440                 445             


Met Asn Arg Ile Gly Phe Tyr Leu Phe Asn Asp Gln Gly Asp Lys Val 
    450                 455                 460                 


Glu Asn Lys Ile Leu Pro Ser Leu Cys Lys Asn Lys Asn Leu Glu Arg 
465                 470                 475                 480 


Lys Val Glu Ile Lys Val Asn Lys Ile Gln Pro Thr Gly Phe Ile Ser 
                485                 490                 495     


Thr His Met Leu Pro Lys Phe Leu Ile Ser Tyr Leu Met Gly Asp Val 
            500                 505                 510         


Asn Glu Lys Asn Gly Glu Lys Thr Ile Thr His Phe Leu Glu Lys Val 
        515                 520                 525             


Asn Val Ser Ile Leu Asp Gln Asn Ile Ile Asn Gln Ile Lys Ser Glu 
    530                 535                 540                 


Ile Gln Asn Leu Asp Pro Ile Glu Phe Thr Lys Arg Cys Pro Lys Leu 
545                 550                 555                 560 


Ser Ala Ile Lys Asn Val Lys Lys Leu Arg Val Ala Gly Ala Ile Asp 
                565                 570                 575     


Lys Lys Ile Val Glu Tyr Gln Tyr Ile Asn Asp Thr Asp Ile Ala Lys 
            580                 585                 590         


Leu Val Gln Lys Thr Gly Leu Ala Tyr Asp Thr Met Val Thr Tyr Ser 
        595                 600                 605             


Lys Asp Lys Phe Lys Glu Lys Thr Asn His Leu Asn Leu Ser Lys Lys 
    610                 615                 620                 


Glu Leu Glu Thr Phe Ala His Ile Lys Tyr Lys Tyr Tyr Leu Ser Glu 
625                 630                 635                 640 


Arg Arg Lys Ala Leu Asp Ser Val Leu Lys Ala Tyr Phe Pro Glu Ile 
                645                 650                 655     


Gly Ser Gln Asp Ile Pro Lys Glu Leu Tyr Asn Tyr Leu Leu Asn Ile 
            660                 665                 670         


Asn Glu Gln Asp Asn Lys Lys Leu Glu His Arg Arg Ile Lys Asp Glu 
        675                 680                 685             


Val Thr Lys Thr Lys Lys Leu Ile Lys Asp Val Asn Arg Ser Leu Lys 
    690                 695                 700                 


Phe Glu Asp Lys Ile Leu Leu Gly Asp Leu Ala Thr Lys Ile Ala Arg 
705                 710                 715                 720 


Asp Ile Ile Asn Met Ile Ile Asp Lys Asp Leu Lys Val Ser Met Thr 
                725                 730                 735     


Asn Pro Phe Ala Asn Arg Leu Gln Asn Leu Ile Ala Tyr Phe Ser Thr 
            740                 745                 750         


Asn Lys Glu Ala Ile Val Ala Leu Cys Glu Ser Tyr Lys Val Phe Glu 
        755                 760                 765             


His Asn Lys Gly His Phe Phe Leu Thr Arg Glu Leu Ile Leu Asn Ser 
    770                 775                 780                 


Thr Gly Val Ile Asp Phe Tyr Ile Arg Tyr Phe Glu Ala Lys Ile Glu 
785                 790                 795                 800 


Lys Ile Lys Glu Val Leu Leu Val Arg Gly Lys Glu Gly Gly Tyr Glu 
                805                 810                 815     


Ile Asn Thr Glu Leu Ile Pro Tyr Ser Tyr Thr Gln Tyr Leu Pro Lys 
            820                 825                 830         


Glu Val Lys Glu Glu Asn Lys Asn Thr Cys Lys Asn Leu Phe Glu Gln 
        835                 840                 845             


Trp Leu Tyr Tyr Lys Gln Lys Ser Pro Val Asn Leu Pro Val Thr Leu 
    850                 855                 860                 


Leu Asp Glu Asp Leu Thr Ser Ala Leu Lys Ser Lys Leu Lys Leu Lys 
865                 870                 875                 880 


Pro Asp Leu Lys Asp Gly Phe Ser Lys Leu Ile Gln Leu Tyr Leu Lys 
                885                 890                 895     


Asp Asp Ala Gln Glu Phe Tyr Ser Phe Asp Arg Val Tyr Arg Asn Asn 
            900                 905                 910         


Asp Asn Glu His Val Ile Lys Tyr Ser Asn Glu Gly Ser Ser Lys Glu 
        915                 920                 925             


Met Gln Ile Lys Tyr Gly Lys Val Ala Val Glu Ser Glu Lys Ile Ile 
    930                 935                 940                 


Arg His Val Leu Leu Lys Asp Arg Ile Leu Arg Val Ile Cys Glu Asp 
945                 950                 955                 960 


Leu Leu Lys Ser Asp Lys Asn Thr Ser Ser Thr Lys Ser Phe Leu Leu 
                965                 970                 975     


Lys Asp Ile Ser Pro Trp Ser Glu Thr Asn Ile Leu Asn Lys Pro Asn 
            980                 985                 990         


Glu Phe Ser Tyr Asn Leu Arg Lys  Asn Ile Asp Gly Ser  Gly Thr Glu 
        995                 1000                 1005             


Tyr Cys  Thr Ile Val Ala Lys  Asp Ser Thr Glu Gln  Ile Arg Gln 
    1010                 1015                 1020             


Ile Asn  Glu Trp Asn Asp Leu  Ser Lys Glu Ile Lys  Ser Lys Phe 
    1025                 1030                 1035             


Leu Lys  Leu Asn Ala Glu Gln  Lys Ile Asp Phe Leu  Thr Thr Gln 
    1040                 1045                 1050             


Asp Glu  Lys Thr Lys Leu Val  Leu Leu Gly Gln Gln  Asn Tyr Gln 
    1055                 1060                 1065             


Trp Lys  Phe Ser Asp Phe Gly  Arg Phe Arg Arg Phe  Met Lys Asp 
    1070                 1075                 1080             


Lys Arg  Ile Asn Glu Met Val  Lys Tyr Phe Glu Pro  Lys Gln Ile 
    1085                 1090                 1095             


Pro Phe  Asp Leu Leu Glu Phe  Gln Ile Leu Gln Tyr  Asn Ile Tyr 
    1100                 1105                 1110             


Arg Glu  Lys Met Phe Asp Lys  Ile Phe Glu Leu Glu  Arg Val Met 
    1115                 1120                 1125             


Ser Glu  Arg Tyr Phe Glu Asp  Ile Lys Ser Lys His  Leu Glu Asn 
    1130                 1135                 1140             


Phe Lys  Tyr Asn Glu Val Gly  Phe Gln Thr Tyr Leu  Asn Val Leu 
    1145                 1150                 1155             


Ser Glu  Lys Ile Ala Ser Gly  Tyr Asp Ile Ala Ile  Leu Lys Trp 
    1160                 1165                 1170             


Gly Arg  Asn Lys Phe Ser His  Thr Glu Ile Val Tyr  Tyr Asn Phe 
    1175                 1180                 1185             


Ile Ser  Lys Ile Ala Val Gln  Asp Ile Glu Glu Phe  Glu Leu Lys 
    1190                 1195                 1200             


Lys His  Leu Glu Gly Tyr Lys  Glu Asn Val Ser Phe  Asn Ile Ala 
    1205                 1210                 1215             


Arg Asn  Ile Tyr Arg Val Phe  Ser Arg Glu Val Asp  Lys Thr Ile 
    1220                 1225                 1230             


Asn Leu  Ile Asn Asn Ser Phe  Lys Ile 
    1235                 1240         


<210>  2086
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2086

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Thr 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2087
<211>  1317
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2087

Met Gly Asn Asp Tyr Lys Lys Gly Asn Tyr Thr Pro Lys Asn Gln Asn 
1               5                   10                  15      


Gly Asn Lys Gln Gln Pro Lys Lys Val Arg Arg Leu Gln Lys Thr Asn 
            20                  25                  30          


Phe Arg Ile Ser Leu Thr Gly Lys His Val Phe Gly Ala Tyr Phe Asn 
        35                  40                  45              


Met Ala Arg Thr Asn Phe Ile Lys Thr Ile Asn Tyr Ile Leu Pro Ile 
    50                  55                  60                  


Ala Gly Val Arg Gly Asn Tyr Ser Glu Ser Gln Ile Asn Lys Leu Leu 
65                  70                  75                  80  


Gln Ala Met Phe Leu Ile Gln Thr Gly Arg Asn Gly Glu Leu Thr Lys 
                85                  90                  95      


Glu Gln Lys Gln Trp Glu Lys Lys Leu Arg Leu Asn Pro Glu Gln Gln 
            100                 105                 110         


Thr Lys Leu Gln Gln Leu Leu Phe Lys His Phe Pro Val Leu Gly Pro 
        115                 120                 125             


Met Met Ala Asp Val Ala Asp His Lys Val Tyr Leu Asn Lys Lys Lys 
    130                 135                 140                 


Ser Asn Val Gln Thr Asp Asp Glu Ala Phe Ala Gln Leu Lys Gly Val 
145                 150                 155                 160 


Ser Leu Ala Asp Cys Leu Asp Met Ile Tyr Leu Met Ala Glu Thr Leu 
                165                 170                 175     


Thr Glu Cys Arg Asn Phe Tyr Thr His Lys Ser Pro Tyr Asn Thr Pro 
            180                 185                 190         


Ser Gln Leu Ala Met Gln Tyr Gln His Gln Glu Lys Ile Ala Gln Lys 
        195                 200                 205             


Leu Asp Lys Val Val Val Ala Ser Arg Arg Ile Leu Lys Asp Arg Glu 
    210                 215                 220                 


Gly Leu Ser Val Asn Glu Val Glu Phe Leu Thr Gly Ile Asp His Leu 
225                 230                 235                 240 


His Gln Glu Thr Val Lys Asp Glu Phe Gly Asn Val Lys Met Lys Gly 
                245                 250                 255     


Gly Lys Val Met Lys Thr Phe Val Glu Tyr Asp Asp Phe Tyr Phe Lys 
            260                 265                 270         


Ile Ser Gly Lys Arg Leu Val Lys Gly Tyr Thr Val Thr Val Lys Asp 
        275                 280                 285             


Asp Lys Pro Val Asn Val Asp Thr Met Leu Pro Ala Leu Ser Asp Phe 
    290                 295                 300                 


Gly Leu Leu Tyr Phe Cys Val Ile Phe Leu Ser Lys Pro Tyr Ala Lys 
305                 310                 315                 320 


Leu Phe Ile Asp Glu Val Arg Leu Phe Glu Phe Ser Pro Phe Ser Asp 
                325                 330                 335     


Asn Glu Asn Met Ile Met Ser Glu Met Leu Ser Ile Tyr Arg Ile Arg 
            340                 345                 350         


Thr Pro Arg Leu His Lys Ile Asp Ser Arg Asp Ser Lys Ala Thr Leu 
        355                 360                 365             


Ala Met Asp Ile Phe Gly Glu Leu Arg Arg Cys Pro Ile Glu Leu Tyr 
    370                 375                 380                 


Asp Leu Leu Asp Lys Asn Ser Gly Gln Pro Phe Phe His Asp Glu Val 
385                 390                 395                 400 


Lys Arg Pro Asn Ser His Thr Pro Glu Val Ser Lys Arg Leu Arg Tyr 
                405                 410                 415     


Asn Asp Arg Phe Pro Thr Leu Ala Leu Arg Tyr Val Asp Glu Thr Glu 
            420                 425                 430         


Leu Phe Lys Arg Ile Arg Phe Gln Leu Gln Leu Gly Ala Phe Arg Tyr 
        435                 440                 445             


Lys Phe Tyr Asp Lys Glu Gly Ile Asp Gly Arg Ile Arg Val Arg Arg 
    450                 455                 460                 


Ile Gln Lys Asp Ile Asn Gly Tyr Gly Arg Leu Gln Glu Val Ala Asp 
465                 470                 475                 480 


Lys Arg Ile Glu Lys Trp Gly Asp Met Leu Gln Lys Arg Glu Glu Arg 
                485                 490                 495     


Ser Val Lys Leu Glu His Glu Glu Leu Tyr Ile Asp Leu Asp Gln Phe 
            500                 505                 510         


Gln Glu Asp Thr Ala Asp Ser Thr Pro Tyr Val Thr Asp Arg Arg Pro 
        515                 520                 525             


Ala Tyr Asn Ile His Ala Asn Arg Ile Gly Leu Tyr Trp Glu Glu Ser 
    530                 535                 540                 


Gln Asn Pro Asn Glu Phe Lys Val Phe Asp Asn Asn Gly Met Tyr Ile 
545                 550                 555                 560 


Pro Glu Leu Val Val Thr Glu Asp Glu Lys Ala Pro Val Lys Met Pro 
                565                 570                 575     


Ala Pro Arg Cys Ala Leu Ser Val Tyr Asp Leu Ser Ala Met Leu Phe 
            580                 585                 590         


Tyr Glu Tyr Leu Arg Glu Gln Glu Asp Gly Asn Thr Pro Ser Ala Glu 
        595                 600                 605             


Gln Ile Ile Ile Asp Tyr Glu Ala Asp Tyr Arg Arg Phe Phe Asn Ala 
    610                 615                 620                 


Val Ala Glu Gly Thr Leu Lys Pro Phe Gln Lys Thr Lys Glu Phe Arg 
625                 630                 635                 640 


Glu Tyr Leu Glu Lys Glu Tyr Pro Arg Leu Arg Met Ala Asp Ile Pro 
                645                 650                 655     


Glu Lys Leu Gln Leu Tyr Leu Thr Cys Lys Gly Leu Thr His Asp Asn 
            660                 665                 670         


Lys Pro Glu Thr Val Arg Glu Arg Leu Ile Arg Leu Ala Ile Glu His 
        675                 680                 685             


Leu Lys Glu Arg Glu Glu Arg Val Gln Arg Arg Leu Glu His Tyr Glu 
    690                 695                 700                 


Glu Asp Arg Lys Met Ile Gly Glu Lys Asp Asn Lys Tyr Gly Lys Lys 
705                 710                 715                 720 


Gly Phe Ala Asp Val Arg His Gly Ala Ile Ala Arg Tyr Leu Ala Gln 
                725                 730                 735     


Ser Met Met Glu Trp Gln Pro Thr Asn Leu Lys Asp Lys Glu Lys Gly 
            740                 745                 750         


Arg Asp Lys Leu Thr Gly Met Asn Tyr Asn Val Leu Thr Ala Tyr Leu 
        755                 760                 765             


Ala Thr Phe Gly Gln Pro Gln Thr Pro Glu Glu Asp Phe Thr Pro Arg 
    770                 775                 780                 


Thr Leu Glu Gln Val Leu Thr Gly Ala His Leu Ile Gly Gly Asn Asn 
785                 790                 795                 800 


Pro His Pro Phe Ile Asp Lys Val Leu Ala Leu Gly Asn Arg Asn Ile 
                805                 810                 815     


Glu Glu Leu Tyr Leu His Tyr Leu Glu Glu Glu Leu Lys His Ile Arg 
            820                 825                 830         


Ser Arg Lys Gln Ser Leu Ser Ser Asn Pro Ser Asp Lys Ala Leu Ser 
        835                 840                 845             


Ala Leu Pro Phe Val His His Asp Arg Leu Arg Phe His Glu Arg Thr 
    850                 855                 860                 


Asn Glu Glu Met Lys Ala Leu Ala Ala Arg Tyr Thr Thr Ile Gln Leu 
865                 870                 875                 880 


Pro Asp Gly Leu Phe Thr Pro Tyr Ile Val Glu Leu Leu Lys Gln Tyr 
                885                 890                 895     


Val Glu Leu Gln Thr Ala Leu Asn Gln Asp Ile Pro Ala Asn Leu Asn 
            900                 905                 910         


Pro Thr Asn Asn Ala Ala Tyr Leu Ile Thr Gln Phe Tyr Gln Thr Val 
        915                 920                 925             


Leu Lys Asp Asp Ala Gln Pro Phe Tyr Ile Ser Gly Lys Thr Tyr Thr 
    930                 935                 940                 


Arg His Lys Glu Gly Glu Lys Asp Glu Val Phe Ser Phe Lys Arg Ala 
945                 950                 955                 960 


Tyr Glu Leu Phe Ser Val Leu Asn Asn Glu Lys Lys Arg Thr Phe Pro 
                965                 970                 975     


Phe Glu Leu Ile Pro Leu Phe Leu Thr Ser Glu Glu Ile Gln Lys Arg 
            980                 985                 990         


Leu Ser Glu Lys Leu Leu Asp Asp  Asp Gly Asn Pro Met  Pro Glu Gln 
        995                 1000                 1005             


Gly Lys  Arg Gly Lys Ala Ala  Thr Asp Ser Gln Gly  Asn Ile Ile 
    1010                 1015                 1020             


Trp Gln  Arg Lys Ile Lys Leu  Asp Ile Ser Asn Tyr  Val Ser Ser 
    1025                 1030                 1035             


Leu Ser  Asp Lys Asp Leu Lys  Ile Ser Met Asn Gln  Ser Trp Lys 
    1040                 1045                 1050             


Gln Lys  Glu Glu Glu Arg Thr  Glu Lys Arg Glu Ala  Leu Gln Ser 
    1055                 1060                 1065             


Arg Leu  Thr Arg Gln Ile His  Asp Ile Lys Tyr Asn  Glu Arg Thr 
    1070                 1075                 1080             


Leu Arg  Arg Tyr Lys Thr Gln  Asp Met Val Leu Phe  Leu Ile Ala 
    1085                 1090                 1095             


Lys Lys  Leu Phe Glu Asn Ile  Ile Phe Glu Gln Gly  Asn Glu Val 
    1100                 1105                 1110             


Asn Ser  Glu Gln Met Arg Leu  Ser Lys Val Cys Asp  Glu Ala Phe 
    1115                 1120                 1125             


Leu Arg  Gln Thr Leu Thr Phe  Arg Val Pro Val Thr  Val Gly Asp 
    1130                 1135                 1140             


Lys Thr  Ile Tyr Val Glu Gln  Glu Asn Met Ser Leu  Lys Asn Tyr 
    1145                 1150                 1155             


Gly Glu  Phe Tyr Arg Phe Leu  Thr Asp Asp Arg Leu  Met Ser Leu 
    1160                 1165                 1170             


Leu Glu  Asn Ile Ile Gly Thr  Leu Lys Pro Asn Glu  Asp Gly Asp 
    1175                 1180                 1185             


Leu Val  Ile Arg His Thr Asp  Leu Met Ser Glu Leu  Ala Ala Tyr 
    1190                 1195                 1200             


Asp Gln  His Arg Ser Thr Val  Phe Lys Leu Ile Gln  Gln Ile Glu 
    1205                 1210                 1215             


Asn Leu  Ile Ile Glu Lys Asn  Asn Ala Leu Lys Asn  Pro Asp Ser 
    1220                 1225                 1230             


Glu Asp  Phe Trp Val Lys Glu  Gly Leu Pro Lys Arg  Asn Asn Phe 
    1235                 1240                 1245             


Ala Ser  Leu Leu Glu Leu Ile  Asp Gln Leu Asn Asn  Val Ala Leu 
    1250                 1255                 1260             


Thr Asp  Glu Glu Arg Lys Leu  Leu Val Ala Ile Arg  Asn Ala Phe 
    1265                 1270                 1275             


Ser His  Asn Ser Tyr Asn Ile  Asp Phe Ser Leu Ile  Lys Asp Val 
    1280                 1285                 1290             


Lys His  Leu Pro Glu Val Ala  Lys Gly Ile Leu Gln  His Leu Gln 
    1295                 1300                 1305             


Leu Val  Leu Gly Val Glu Gln  Thr Lys 
    1310                 1315         


<210>  2088
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2088

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2089
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2089

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Ser Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2090
<211>  985
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2090

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Asn Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys Gly Tyr 
                165                 170                 175     


Ala Phe Phe Ile Ser Lys Phe Leu Glu Arg Lys Tyr Ser Tyr Leu Phe 
            180                 185                 190         


Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln Tyr Arg 
        195                 200                 205             


Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro Val Glu 
    210                 215                 220                 


Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu Asp Ile 
225                 230                 235                 240 


Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr Leu Glu 
                245                 250                 255     


Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr Asp Ala 
            260                 265                 270         


Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe Arg Ser 
        275                 280                 285             


Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala Asp Phe 
    290                 295                 300                 


Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His Asn Gly 
305                 310                 315                 320 


Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr Ile Asn 
                325                 330                 335     


Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser Ala Lys 
            340                 345                 350         


Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser Thr Asp 
        355                 360                 365             


Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln Ser Thr 
    370                 375                 380                 


Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val Leu Pro 
385                 390                 395                 400 


Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala Lys Met 
                405                 410                 415     


Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala Met Leu 
            420                 425                 430         


Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His Cys Pro 
        435                 440                 445             


Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser Thr Lys 
    450                 455                 460                 


Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg Val Met 
465                 470                 475                 480 


Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu Arg Ile 
                485                 490                 495     


Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile Leu Lys 
            500                 505                 510         


Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp Leu Gln 
        515                 520                 525             


Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn Phe Gln 
    530                 535                 540                 


Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn Asp Leu 
545                 550                 555                 560 


Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn Pro His 
                565                 570                 575     


Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile Glu Phe 
            580                 585                 590         


Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg Ile Gln 
        595                 600                 605             


Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro Leu Arg 
    610                 615                 620                 


Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu Ala Ile 
625                 630                 635                 640 


Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys Leu Lys 
                645                 650                 655     


Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu Lys Ser 
            660                 665                 670         


Pro Ala Leu Asn Val Ser Tyr Leu Ile His Asn Tyr Phe Arg Ala Tyr 
        675                 680                 685             


Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn Tyr Arg 
    690                 695                 700                 


Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser Tyr Leu 
705                 710                 715                 720 


Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro Ser Lys 
                725                 730                 735     


Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp Arg Leu 
            740                 745                 750         


Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile Ile Arg 
        755                 760                 765             


Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys Glu Tyr 
    770                 775                 780                 


Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu Glu Asn 
785                 790                 795                 800 


Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp Leu Asn 
                805                 810                 815     


Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr Gly Lys 
            820                 825                 830         


Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn Lys Val 
        835                 840                 845             


Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val Lys Ile 
    850                 855                 860                 


Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu Glu Ala 
865                 870                 875                 880 


Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala Met Val 
                885                 890                 895     


Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr Tyr Asp 
            900                 905                 910         


Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln Lys Ile 
        915                 920                 925             


Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His Asp Lys 
    930                 935                 940                 


Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val Tyr Ala 
945                 950                 955                 960 


Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile Lys Leu 
                965                 970                 975     


Glu Asp Leu Ser Asn Asp Ser Ser Ala 
            980                 985 


<210>  2091
<211>  1146
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2091

Met Glu Ser Ile Ile Gly Leu Gly Leu Ser Phe Asn Pro Tyr Lys Thr 
1               5                   10                  15      


Ala Asp Lys His Tyr Phe Gly Ser Phe Leu Asn Leu Ala Asp Asn Asn 
            20                  25                  30          


Leu Lys Ala Val Phe Ala Glu Phe Lys Glu Arg Ile Ser Asp Lys Ser 
        35                  40                  45              


Lys Asp Glu Asp Ile Ser Asn Leu Ile Glu Lys His Phe Ile Asp Asn 
    50                  55                  60                  


Met Ser Ile Val Asp Tyr Glu Lys Asn Ile Ser Ile Leu Asn Gly Tyr 
65                  70                  75                  80  


Leu Pro Ile Ile Asp Phe Leu Asp Asp Glu Leu Glu Asn Asn Leu Asn 
                85                  90                  95      


Thr Arg Val Lys Asn Phe Lys Lys Ser Phe Ile Ile Leu Ala Glu Ala 
            100                 105                 110         


Leu Glu Thr Leu Arg Asn Tyr Tyr Thr His Phe Tyr His Asp Pro Ile 
        115                 120                 125             


Thr Phe Gly Asp Asn Lys Glu Pro Leu Leu Glu Leu Leu Asp Glu Val 
    130                 135                 140                 


Leu Leu Lys Thr Ile Leu Asp Val Lys Lys Lys Tyr Leu Lys Thr Asp 
145                 150                 155                 160 


Lys Thr Lys Glu Ile Leu Lys Asp Ser Leu Arg Glu Glu Met Asp Leu 
                165                 170                 175     


Leu Val Ile Arg Lys Thr Asp Glu Leu Arg Glu Lys Lys Lys Thr Asn 
            180                 185                 190         


Pro Lys Phe Lys Phe Ser Thr Asp Pro Thr Gln Ile Arg Asn Ser Ile 
        195                 200                 205             


Phe Asn Asp Ala Phe Gln Gly Leu Leu Tyr Glu Asp Lys Glu Asn Asn 
    210                 215                 220                 


Gly Lys Thr Gln Val Ser Tyr Arg Ala Lys Thr Lys Leu Asn Pro Lys 
225                 230                 235                 240 


Asp Ile His Lys Gln Glu Glu Arg Asp Phe Glu Ile Pro Leu Ser Thr 
                245                 250                 255     


Ser Gly Ile Val Phe Leu Met Ser Leu Phe Leu Ser Lys Lys Glu Ile 
            260                 265                 270         


Glu Asp Phe Lys Ser Asn Ile Lys Gly Phe Lys Gly Lys Val Val Lys 
        275                 280                 285             


Asp Glu Asn His Asn Ser Leu Lys Tyr Met Ala Thr His Arg Val Tyr 
    290                 295                 300                 


Ser Ile Leu Ala Phe Lys Gly Leu Lys Tyr Arg Ile Lys Thr Asp Thr 
305                 310                 315                 320 


Phe Ser Lys Val Thr Leu Met Met Gln Met Ile Asp Glu Leu Ser Lys 
                325                 330                 335     


Val Pro Asp Cys Val Tyr Gln Asn Leu Ser Glu Thr Lys Gln Lys Asp 
            340                 345                 350         


Phe Ile Glu Asp Trp Asn Glu Tyr Leu Lys Asp Asn Glu Glu Asn Thr 
        355                 360                 365             


Glu Asn Leu Glu Asn Ser Arg Val Val His Pro Leu Ile Arg Lys Arg 
    370                 375                 380                 


Tyr Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe 
385                 390                 395                 400 


Ala Asn Phe Lys Thr Leu Lys Phe Gln Val Phe Met Gly Tyr Tyr Ile 
                405                 410                 415     


His Asp Gln Arg Thr Lys Thr Ile Gly Thr Thr Asn Ile Thr Thr Glu 
            420                 425                 430         


Arg Thr Val Lys Glu Lys Ile Asn Val Phe Gly Lys Leu Ser Lys Met 
        435                 440                 445             


Asp Asn Leu Lys Lys His Phe Phe Ser Gln Leu Ser Asp Glu Glu Asn 
    450                 455                 460                 


Thr Asp Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Phe Leu Thr Gln 
465                 470                 475                 480 


Ala Asp Asn Ser Pro Ala Asn Asn Ile Pro Ile Tyr Leu Glu Leu Lys 
                485                 490                 495     


Asn Gln Gln Ile Ile Lys Glu Lys Asp Asp Ile Lys Ala Glu Val Asn 
            500                 505                 510         


Asn Ser Gln Asn Arg Asn Pro Asn Lys Pro Ser Lys Arg Asp Leu Leu 
        515                 520                 525             


Asn Lys Ile Ser Asn Thr Asn Glu Asp Phe Tyr Gln Gly Asp Pro Thr 
    530                 535                 540                 


Ala Ile Leu Ser Leu Asn Glu Ile Pro Ala Leu Leu His Leu Phe Leu 
545                 550                 555                 560 


Val Gln Pro Asp Asn Lys Thr Gly Gln Gln Ile Glu Asn Ile Ile Arg 
                565                 570                 575     


Ile Lys Ile Glu Lys Gln Phe Asn Ser Ile Lys Asn Pro Ser Lys Asp 
            580                 585                 590         


Asp Lys Gly Val Pro Lys Ser Leu Phe Ala Asp Thr Asn Val Arg Val 
        595                 600                 605             


Asn Ala Ile Lys Leu Lys Lys Asp Leu Gly Glu Glu Leu Asp Met Leu 
    610                 615                 620                 


Asn Lys Lys Gln Ile Val Phe Lys Glu Asn Gln Lys Ala Ser Ser Asn 
625                 630                 635                 640 


Tyr Asp Glu Leu Leu Lys Lys His Gln Phe Thr Pro Lys Asn Lys Arg 
                645                 650                 655     


Pro Ala Leu Arg Lys Tyr Val Phe Tyr Asn Ser Glu Lys Gly Glu Glu 
            660                 665                 670         


Ala Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Lys Gly Phe 
        675                 680                 685             


Lys Thr Lys Trp Lys Gly Tyr Gln His Ser Glu Leu Gln Arg Lys Leu 
    690                 695                 700                 


Ala Phe Tyr Asp Arg His Thr Lys Gln Asp Ile Lys Glu Leu Leu Ser 
705                 710                 715                 720 


Gly Cys Glu Phe Asp His Phe Leu Leu Asp Ile Asn Ala Cys Phe Lys 
                725                 730                 735     


Glu Asp Asp Phe Glu Asp Phe Phe Ser Lys Tyr Leu Lys Asn Arg Ile 
            740                 745                 750         


Glu Thr Leu Asn Ile Ile Leu Lys Gln Leu His Asp Phe Lys Asn Glu 
        755                 760                 765             


Pro Thr Pro Leu Lys Gly Val Phe Lys Asn Cys Leu Lys Phe Leu Lys 
    770                 775                 780                 


Gln Lys Asn Tyr Val Thr Glu Asn Pro Glu Ile Ile Lys Lys Arg Ile 
785                 790                 795                 800 


Leu Ala Lys Pro Ala Phe Leu Pro Arg Gly Ile Phe Asp Glu Arg Pro 
                805                 810                 815     


Thr Met Lys Lys Gly Lys Asn Pro Leu Ile Asp Arg Asp Glu Phe Ala 
            820                 825                 830         


Lys Trp Phe Val Glu Tyr Leu Glu Asn Lys Asp Tyr Gln Lys Phe Tyr 
        835                 840                 845             


Asn Ser Glu Glu Tyr Arg Ile Arg Asp Ala Asp Phe Lys Lys Asn Ala 
    850                 855                 860                 


Val Ile Lys Lys Gln Lys Leu Lys Asp Phe Tyr Thr Leu Gln Met Val 
865                 870                 875                 880 


Asn Tyr Leu Leu Lys Glu Val Phe Gly Lys Asp Glu Met Asn Leu Gln 
                885                 890                 895     


Leu Ser Glu Leu Phe Gln Thr Arg Gln Glu Arg Leu Lys Leu Gln Gly 
            900                 905                 910         


Ile Ala Lys Lys Gln Met Asn Lys Glu Thr Gly Asp Ser Ser Glu Asn 
        915                 920                 925             


Thr Arg Asn Gln Thr Tyr Ile Trp Asn Lys Asp Val Pro Val Ser Phe 
    930                 935                 940                 


Phe Asn Gly Lys Val Thr Ile Asp Lys Val Lys Leu Lys Asn Ile Gly 
945                 950                 955                 960 


Lys Tyr Lys Arg Tyr Glu Arg Asp Glu Arg Val Lys Thr Phe Ile Gly 
                965                 970                 975     


Tyr Glu Val Asp Glu Lys Trp Met Met Tyr Leu Pro His Asn Trp Lys 
            980                 985                 990         


Asp Arg Tyr Ser Val Lys Pro Ile  Asn Val Ile Asp Leu  Gln Ile Gln 
        995                 1000                 1005             


Glu Tyr  Glu Glu Ile Arg Ser  His Glu Leu Leu Lys  Glu Ile Gln 
    1010                 1015                 1020             


Asn Leu  Glu Gln Tyr Ile Tyr  Asp His Thr Thr Asp  Lys Asn Thr 
    1025                 1030                 1035             


Leu Leu  Gln Asp Gly Asn Pro  Asn Phe Lys Met Tyr  Val Leu Asn 
    1040                 1045                 1050             


Gly Leu  Leu Thr Gly Ile Lys  Gln Val Asn Ile Ala  Asp Phe Ile 
    1055                 1060                 1065             


Val Leu  Lys Gln Asn Thr Asn  Phe Asp Lys Ile Asp  Phe Thr Gly 
    1070                 1075                 1080             


Ile Ala  Ser Cys Ser Glu Leu  Glu Lys Lys Thr Ile  Ile Leu Ile 
    1085                 1090                 1095             


Ala Ile  Arg Asn Lys Phe Ala  His Asn Gln Leu Pro  Asn Lys Thr 
    1100                 1105                 1110             


Ile Tyr  Asp Leu Ala Asn Glu  Phe Leu Lys Lys Glu  Lys Arg Glu 
    1115                 1120                 1125             


Thr Tyr  Ala Asn Tyr Tyr Leu  Lys Val Leu Lys Lys  Met Ile Ser 
    1130                 1135                 1140             


Asp Leu  Ala 
    1145     


<210>  2092
<211>  1081
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2092

Met Gln Ala Gln Ser Leu Phe Asp Glu Tyr Lys His Leu Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Val Met Ser Ile Met Asn Ile Ile Thr Val Leu Asn His Ile 
            20                  25                  30          


His Gln Ile Ala Gly Leu Lys Arg Asn Glu Leu Gly Asp Asp Asp Asn 
        35                  40                  45              


Ile Tyr Ser His Pro Val Leu Lys Tyr Ile Ala Pro Glu Asn Asn Ser 
    50                  55                  60                  


Thr Thr Leu Pro Glu Lys Arg Asp Leu Ile Lys Glu Leu Leu Leu Glu 
65                  70                  75                  80  


Tyr Leu Pro Phe Leu Glu Ala Met Lys Asp Cys Tyr Lys Glu Val Lys 
                85                  90                  95      


Val Glu Lys Asp Lys Arg Asn Asn Lys Tyr Val Lys Asp Lys Lys Gln 
            100                 105                 110         


Val Phe Ile Arg Asn Tyr Ser Asp Ile Tyr Cys Ile Tyr Trp Thr Leu 
        115                 120                 125             


Tyr Asn Ile Phe Ser Thr Leu Ile Asn Tyr Arg Asp Lys Ser Cys His 
    130                 135                 140                 


Tyr Arg Phe Ile Pro Ser Lys Asp Gln Glu Glu Tyr Ser Lys Arg Thr 
145                 150                 155                 160 


Glu Tyr Asp Thr Val Arg Ile Ile Asn Lys Tyr Tyr Thr Tyr Ala Leu 
                165                 170                 175     


Arg Lys Thr Lys Glu Lys Tyr Gly Tyr Thr Thr Glu Gln Leu Ser Phe 
            180                 185                 190         


Ile Gln Asn Asn Arg Tyr Thr Asp Asp Lys Lys Val Asn Phe Asn Phe 
        195                 200                 205             


Phe Leu Ser Met Gln Ser Ser Asn Asn Asn Leu Ser His Val Gly Val 
    210                 215                 220                 


Ala Gln Leu Ile Cys Leu Phe Leu Gln Lys Lys Asp Val Asp Asn Phe 
225                 230                 235                 240 


Leu Glu Asn Leu Pro Ile Tyr Asp Asn Arg Tyr Cys Leu Gly Ile Asp 
                245                 250                 255     


Glu His Met Ile Ile Lys Arg Ser Leu Ala Leu His Ser Ile Lys Leu 
            260                 265                 270         


Pro Lys Glu Arg Leu Asn Ser Glu Lys Lys Asp Met Ala Ile Ala Met 
        275                 280                 285             


Asp Met Leu Asn Glu Leu Lys Arg Cys Pro Lys Glu Leu Phe Asn Thr 
    290                 295                 300                 


Leu Pro Phe Asp Lys Gln Glu Arg Phe Arg Ile Ile Ser Ser Asp His 
305                 310                 315                 320 


Lys Glu Val Leu Leu Met Arg Ser Thr Asp Arg Phe Val Pro Leu Ile 
                325                 330                 335     


Leu Gln Tyr Ile Asp Cys Asn Lys Lys Phe Lys Asp Ile Arg Phe His 
            340                 345                 350         


Val Asn Met Gly Lys Leu Arg Tyr Leu Phe Ser Pro Asn Lys Leu Cys 
        355                 360                 365             


Ile Asp Asn Gln Glu Arg Val Arg Met Leu Glu His Leu Leu Asn Gly 
    370                 375                 380                 


Tyr Gly Arg Ile Asp Glu Val Glu Tyr Leu Arg Lys Ala Pro Asn Gly 
385                 390                 395                 400 


Thr Phe Gly Asn Thr Asn Ile Pro Ile Lys Gly Phe Gly Glu Ile Glu 
                405                 410                 415     


Arg Asp Ser Ala Asp Ser Asn Asn Tyr Pro Tyr Ile Val Asp Thr His 
            420                 425                 430         


Thr His Tyr Ile Leu Asn Asn Asn Lys Val Glu Phe Cys Phe Cys Glu 
        435                 440                 445             


Asp Ser Lys Asn Lys Asn Val Phe Pro Thr Ile Glu Lys Glu Ile Asn 
    450                 455                 460                 


Gly Lys Trp Tyr Val Glu Lys Thr Ala Pro His Cys Arg Ile Ser Phe 
465                 470                 475                 480 


Phe Glu Ile Pro Ala Met Ala Phe His Met Phe Leu Cys Gly Ser Glu 
                485                 490                 495     


Lys Thr Glu Lys Leu Ile Lys Asp Val Tyr Asn Asn Tyr Ile Ser Leu 
            500                 505                 510         


Phe Asn Ala Leu Lys Asn Gly Ala Leu Thr Glu Glu Asn Tyr Lys Asp 
        515                 520                 525             


Phe Asn Ile Pro Glu Cys Asp Met Pro Lys Lys Ile Leu Asp Phe Leu 
    530                 535                 540                 


Lys Gly Lys Ala Glu Gly Lys Ser Ile Asp Gly Tyr Val Lys Asn Ile 
545                 550                 555                 560 


Leu Lys Lys Glu Leu Lys Asp Thr Arg Lys Arg Ile Glu Gln Ala Pro 
                565                 570                 575     


Ser Glu Lys Asp Gln Met Pro Ser Lys Arg Asn Lys Ile Gly Thr Lys 
            580                 585                 590         


Ser Tyr Lys Arg Val Leu Thr Gly Lys Leu Ala Asp Phe Leu Ala Lys 
        595                 600                 605             


Asp Ile Val Lys Tyr Gln Pro Thr Leu Cys Ala Gly Asp Asp Tyr Gly 
    610                 615                 620                 


Ile Asp Arg Met Thr Gly Met Asn Tyr Arg Ile Met Gln Ala Thr Ile 
625                 630                 635                 640 


Ala Thr Tyr Asn Asp Asp Asp Asp Phe Asp Thr Phe Tyr Asn Val Phe 
                645                 650                 655     


Lys Met Ala Gly Leu Val Asp Gly Asp Glu Arg Lys Asn His Pro Phe 
            660                 665                 670         


Leu Lys Lys Val Leu Leu Ser Lys Pro Gln Asn Thr Val Ala Phe Asn 
        675                 680                 685             


Ile Lys Tyr Leu Lys Glu Lys Glu Ile Tyr Leu Arg Asn Ile Glu Lys 
    690                 695                 700                 


Lys Asn Ile Ile Pro Pro Phe Val Asn Arg Glu Arg Asn Lys Trp Cys 
705                 710                 715                 720 


Glu Arg Asp Cys Glu Tyr Tyr Arg Ile Leu Gly Glu Asn Leu Leu Asp 
                725                 730                 735     


Leu Pro Ile Glu Leu Pro Arg Gln Met Phe Tyr Lys Asp Ile Arg Ala 
            740                 745                 750         


Gln Leu Glu Pro Leu Met Pro Glu Ile Asp Phe Ser Gln Thr Asn Thr 
        755                 760                 765             


Thr Tyr Leu Ile Ala Glu Tyr Leu Lys Arg Val Arg Gly Asp Asp Phe 
    770                 775                 780                 


Gln Glu Phe Tyr Ser Trp Glu Arg Asn Tyr Arg Tyr Ile Asp Phe Leu 
785                 790                 795                 800 


Lys Cys Ile Arg Asp Asp Asn Gly Arg Ile Cys Ala Gln Tyr Thr Thr 
                805                 810                 815     


Thr Glu Glu Arg Glu Ser Leu Trp Glu Asp Ser Lys Asn Arg Thr Ala 
            820                 825                 830         


Glu Tyr Lys Arg Ser Glu Glu Gln Lys Asn Glu Lys Lys Asp Lys Asn 
        835                 840                 845             


Phe Glu Asp Ser Leu Glu Glu Arg Ile Ser Ser Ser His Ile Lys Phe 
    850                 855                 860                 


Gln Asn Thr Glu Lys His Ile Arg Arg Tyr Lys Val Gln Asp Ala Leu 
865                 870                 875                 880 


Leu Phe Met Ile Ala Glu Lys Gln Phe Gly Lys Tyr Leu Asp Asp Ile 
                885                 890                 895     


Lys Ala Lys Asn Phe Lys Leu Lys Asp Ile Met Pro Asp Thr Asp Lys 
            900                 905                 910         


Gly Ile Leu Ser Glu Thr Met Pro Ile Asp Phe Thr Phe Thr Lys Lys 
        915                 920                 925             


Asn Ile Lys Tyr Asn Ile His Ala Lys Asn Leu Lys Phe Lys Glu Tyr 
    930                 935                 940                 


Gly Asp Leu Phe Ile Leu Ala Asn Asp Lys Arg Leu Glu Ser Leu Trp 
945                 950                 955                 960 


Lys Ile Leu Ala Thr Asp Thr Val Asn Lys Glu Glu Ile Ser Glu Glu 
                965                 970                 975     


Phe Ala Lys Tyr Asp Phe Cys Arg Pro Asp Ile Thr Lys Leu Val Leu 
            980                 985                 990         


Asp Phe Glu Lys Asp Val Leu Glu  Lys Tyr Pro Glu Ile  Ile Glu Glu 
        995                 1000                 1005             


Ala Glu  Lys Glu Tyr Lys Lys  Phe Asp Phe Lys Phe  Ile Leu Asp 
    1010                 1015                 1020             


Trp Leu  Ile Asn Lys Lys Lys  Leu Asn Tyr Gly Ile  Arg Asn Lys 
    1025                 1030                 1035             


Leu Leu  Leu Ile Arg Asn Ala  Phe Asn His Asn Ser  Tyr Pro Asp 
    1040                 1045                 1050             


Lys Lys  Tyr Ala Glu Val Arg  Glu Leu Pro Glu Ile  Ala Thr Asn 
    1055                 1060                 1065             


Leu Lys  Lys Thr Phe Asp Glu  Asn Ala Lys Lys Tyr  Glu 
    1070                 1075                 1080     


<210>  2093
<211>  1126
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2093

Met Glu Thr Asn Gln Lys Pro Asn Tyr Lys Lys Phe Thr Asn Glu Gln 
1               5                   10                  15      


Asp Lys Pro Phe Phe Ser Gly Tyr Leu Asn Thr Ala Lys Gln Asn Val 
            20                  25                  30          


Phe Ile Ile Phe Arg Asp Ile Ser Glu Arg Leu Gly Leu Gly Phe Asp 
        35                  40                  45              


Leu Ser Asn Asp Asp Asn Ile Met Asn Ala Asp Leu Trp Glu Tyr Leu 
    50                  55                  60                  


Lys Asn Asn Lys Arg Pro Glu Ile Thr Gln His Ile Ile Glu Lys Leu 
65                  70                  75                  80  


Met Tyr His Phe Pro Phe Ala Ser His Leu Thr Thr Asn Tyr Ala Tyr 
                85                  90                  95      


Tyr Lys Arg Lys Glu Asn Gln Ala Glu Pro Leu Asp Tyr Tyr Glu Ile 
            100                 105                 110         


Phe Glu Leu Leu Ile Lys Gln Leu Tyr Glu Tyr Arg Asn Phe Tyr Thr 
        115                 120                 125             


His Val Val His Asp Pro Val Ile Met Asn Lys Val Ile Ile Asn Gly 
    130                 135                 140                 


Met Arg Ile Leu Phe Asp Ala Ala Arg Ile Glu Val Lys Asp Arg Phe 
145                 150                 155                 160 


Asn Leu Lys Thr Glu Asp Val Asn His Leu Val Arg Leu Gly Pro Lys 
                165                 170                 175     


Gly Lys Glu Asn Lys Asn Phe Tyr Tyr Asn Phe Ser Asp Asp Glu Arg 
            180                 185                 190         


Asn Val Ser Glu Lys Gly Leu Ala Phe Phe Ile Cys Leu Gly Leu Gln 
        195                 200                 205             


Arg Lys Asp Ala Gln Ile Phe Leu Lys Ser Leu Val Gly Phe Lys Leu 
    210                 215                 220                 


Ser Glu Ser Pro Ser Gln Lys Ala Thr Leu Glu Val Tyr Thr Asn Tyr 
225                 230                 235                 240 


Ser Pro Arg Ile Pro Gln Pro Arg Leu Thr Ser Asp Asn Ser Ile Glu 
                245                 250                 255     


Gly Leu Leu Leu Asp Met Val Asn Glu Leu Lys Arg Cys Pro Lys Glu 
            260                 265                 270         


Leu Tyr His Leu Leu Ser Ile Glu Asp Arg Glu Lys Phe Lys Ala Val 
        275                 280                 285             


Lys Glu Asp Asn Thr Tyr Asp Asp Asn Asp Glu Tyr Glu Ala Met Pro 
    290                 295                 300                 


Val Leu Lys Arg Ser Arg Asn Arg Phe Phe Tyr Phe Ala Leu Arg Tyr 
305                 310                 315                 320 


Leu Asp Asn Asn Leu Gln Asn Ile Lys Phe His Ile Asp Leu Gly Asn 
                325                 330                 335     


Tyr Cys Phe His Val Tyr Glu Gln Glu Ile Glu Glu Ile Val Arg Lys 
            340                 345                 350         


Arg Arg Trp Ile Lys Arg Met Thr Ser Phe Gly Asn Leu Glu Asp Phe 
        355                 360                 365             


Ala Asp Lys Met Arg Pro Ala Tyr Trp Val Glu Lys Thr Leu Lys Leu 
    370                 375                 380                 


Glu Asp Lys Lys Val Asp Asn Pro Asn Ile Tyr Ile Thr Asp Thr Thr 
385                 390                 395                 400 


Pro His Tyr His Ile Asn Gly Gln Asn Ile Gly Ile Lys Phe Ile Asn 
                405                 410                 415     


Asn Tyr Val Ala Leu Arg Lys Asn Asn Lys Ile Trp Pro Glu Leu Pro 
            420                 425                 430         


Asp Phe Gly Asp Asn Asn Lys Thr Asn Lys Pro Arg Asn Glu Thr Pro 
        435                 440                 445             


Asp Cys Trp Leu Ser Leu Tyr Glu Leu Pro Ser Ile Val Phe Tyr His 
    450                 455                 460                 


Leu Leu Lys Gln Gln Asn Ile Gly Leu Pro Ser Val Glu Arg Ile Ile 
465                 470                 475                 480 


Asn Asp His Arg Asn Gln Ile Arg Gly Phe Phe Asn Asp Leu Glu Asn 
                485                 490                 495     


Asn Arg Ile Val Pro Ser Phe Thr Asp Thr Thr Leu Lys Ala Glu Leu 
            500                 505                 510         


Lys Asn Arg Gly Leu Lys Lys Ser Gln Ile Pro Ser Ala Ile Val Lys 
        515                 520                 525             


Tyr Leu Thr Ser Lys Pro Val Met Ser Phe Glu Ala Lys Ala Ser Lys 
    530                 535                 540                 


Arg Leu Ser Glu Leu Val Thr Glu Thr Ser Glu Lys Leu Asp Lys Ile 
545                 550                 555                 560 


Lys Arg Gln Glu Gln His Tyr Leu Lys Lys Pro Gly Ser Lys Asp Tyr 
                565                 570                 575     


Ile Asp Met Lys Cys Gly His Leu Ala Asp Phe Leu Ala Arg Asp Met 
            580                 585                 590         


Ile Ser Leu Gln Lys Pro Tyr Asn Asn Met Asp Gly Lys Ala Asn Ser 
        595                 600                 605             


Thr Glu Phe Gln Ile Leu Gln Ser Lys Leu Ala Tyr Phe Gly Lys Asn 
    610                 615                 620                 


Lys Asp Ser Leu Ser Lys Thr Phe His Leu Phe Asn Leu Met Gly Ser 
625                 630                 635                 640 


Gln Asn Ile His Pro Phe Leu Tyr Lys Ile Asp Ile Asn Gln Cys Ile 
                645                 650                 655     


Gly Ile Leu Asp Phe Tyr Lys Lys Tyr Leu Asp His Arg Tyr Ile Tyr 
            660                 665                 670         


Phe Lys Gln Cys Leu Asn Glu Lys Arg Tyr Ser Glu Tyr His Phe Leu 
        675                 680                 685             


Lys Leu Gly Gly Lys Ser Lys Glu Gln Gly Arg Asp Tyr Phe Val Lys 
    690                 695                 700                 


Leu Ala Asn Thr Leu Gln Lys Glu Thr Val Met Asn Leu Pro Arg Gly 
705                 710                 715                 720 


Leu Phe Leu Glu Ser Ile Ile Arg Ile Leu Lys Ala Asn Asp Asn Ser 
                725                 730                 735     


Arg Pro Phe Ala Ile Glu Ile Glu Lys Met Glu Arg Val Asn Ala Ala 
            740                 745                 750         


Tyr Val Ile Asp Gln Tyr Leu Gly Arg Ile Leu Asn Asp Lys Pro Gln 
        755                 760                 765             


Val Phe Tyr Ser Tyr Asn Lys Ser Tyr Glu Phe Leu Asn Lys Leu Phe 
    770                 775                 780                 


Asp Ser Arg Lys Ile Ser Glu Lys Arg Asn Ala Leu Pro Glu Val Tyr 
785                 790                 795                 800 


Phe Asp Thr Gly Glu Leu Ala Lys Lys Thr Thr Ile Ser Val Lys Gly 
                805                 810                 815     


Gln Lys Asp Asn Glu Ile Thr Arg Ser Leu Thr Lys Thr Val Glu Gln 
            820                 825                 830         


His Ile Lys Arg Asn Arg Ile Phe Asp Glu Lys Glu Lys Thr Lys Val 
        835                 840                 845             


Tyr Asp Gln Tyr Met Ala Arg Tyr Asn Asp Phe Thr Glu Asn Glu Lys 
    850                 855                 860                 


Gln Ile Arg Leu Ala Lys Thr Cys Asp Glu Val Met Phe Met Met Ile 
865                 870                 875                 880 


Asp Asp Ile Phe Arg Lys Tyr Phe Val Leu Asp Asn Gly Thr Leu Lys 
                885                 890                 895     


Lys Lys Thr Ile Glu Ala Ile Pro Phe Ile Gln Leu Gly Asp Asp Tyr 
            900                 905                 910         


Lys Leu Gly Ser Ile Lys Pro Asp Ser Glu Lys Gly Phe Leu Ser Leu 
        915                 920                 925             


Gln Thr Thr Val Lys Leu Gln Met Pro Phe Thr Tyr Glu Thr Asn Thr 
    930                 935                 940                 


Asp Lys Val Leu Lys Val Lys Gly Ala Glu Ser Lys Leu Ser Ala Arg 
945                 950                 955                 960 


Tyr Ile Lys Thr Ile Val Arg Glu Thr Ile Lys Ile Lys Asn Tyr Gly 
                965                 970                 975     


Asp Phe Arg Ala Phe Leu Lys Asp Arg Arg Ile Ser Ser Leu Leu Pro 
            980                 985                 990         


Tyr Leu Ser Asp Arg Glu Ile His  Tyr Glu Ala Leu Gln  Lys Glu Leu 
        995                 1000                 1005             


Glu Leu  Phe Gln Lys Ala Arg  Met Glu Val Phe Asp  Arg Ile Phe 
    1010                 1015                 1020             


Arg Phe  Glu Lys Asp Ile Thr  Gly Ala Phe His Ile  Pro Lys Asn 
    1025                 1030                 1035             


Lys Asn  Gly Tyr Ile Tyr His  Thr Glu Ile Leu Lys  Gln Lys Ile 
    1040                 1045                 1050             


Asn Glu  Gly Asp Glu Arg Phe  Gly Phe Ile Lys Glu  Leu Arg Asn 
    1055                 1060                 1065             


Ala Phe  Asn His Ser Asn Tyr  Pro Ala Tyr Val Leu  Phe Lys Asp 
    1070                 1075                 1080             


Phe Ile  Asp Gly Ser Gln Phe  Asn Glu Leu Arg Asn  Tyr Lys Ser 
    1085                 1090                 1095             


Gly Asp  Thr Glu Val Glu Asn  Lys Ser Val Ile Leu  Gln Phe Lys 
    1100                 1105                 1110             


Asn Leu  Leu Ile Gln Tyr Tyr  Asp Glu Leu Thr Asp  Leu 
    1115                 1120                 1125     


<210>  2094
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2094

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Thr 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2095
<211>  1143
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2095

Met Lys Gln Val Asn Asn Thr His Arg Glu Phe Ser Lys Ile Phe Arg 
1               5                   10                  15      


Asp Lys Gly Tyr Ile Ala Pro Ile Ala Glu Lys Ala His Arg Asn Tyr 
            20                  25                  30          


Ser Ile Val Leu Asn Asn Pro Ile Asn Thr Asp Asp Arg Leu His His 
        35                  40                  45              


Phe Ala Ile Gly His Ala Phe Lys Asp Leu Gly Thr Lys Ala Ile Phe 
    50                  55                  60                  


Lys Tyr Asp Leu Asn Glu Lys Glu Lys Arg Leu Thr Pro Ser Gln Tyr 
65                  70                  75                  80  


Leu Thr Leu Gln Leu Glu Asn Phe Thr Phe Lys Asp Asp Leu Phe Lys 
                85                  90                  95      


Val Ile Glu Asn Ile Arg Asn Ile Asn Ser His Tyr Val His Lys Phe 
            100                 105                 110         


Asp Phe Ile Glu Ile Gly Lys Leu Thr Glu Asn Lys Glu Ala Asn Ile 
        115                 120                 125             


Lys Ile Ile Glu Phe Leu Lys Glu Ala Phe Glu Val Ala Val Leu Val 
    130                 135                 140                 


Asn Phe Leu Glu Glu Glu Lys Ile Thr Tyr Glu Ala Phe Ser Gln Asp 
145                 150                 155                 160 


Glu Glu Ala Asn His Lys Ile Val Ser Tyr Leu Cys Glu Lys Phe Tyr 
                165                 170                 175     


Pro Asn Lys Glu Phe Gln Gln Glu Glu Arg Gln Tyr Phe Leu Ser Leu 
            180                 185                 190         


Asn Lys Asn Ala Ala Ile Glu Ala Leu Leu Phe Ile Gln Val Glu Glu 
        195                 200                 205             


Asp Val Glu Trp Lys Leu Phe Glu Asp His Ser Ile Phe Ser Ile His 
    210                 215                 220                 


Ser Gly Cys Tyr Leu Ser Phe His Ser Cys Leu Phe Met Leu Ser Leu 
225                 230                 235                 240 


Phe Leu Tyr Lys Asp Glu Ala Asn Lys Leu Ile Ser Lys Ile Lys Gly 
                245                 250                 255     


Phe Lys Arg Thr Asp Asp Gln Tyr Ser Phe Lys Arg Asn Ile Phe Met 
            260                 265                 270         


Phe Phe Ser Lys Lys Phe Lys Ser Gln Asp Ile Ser Ser Glu Glu Lys 
        275                 280                 285             


Tyr Leu Val Arg Phe Arg Asp Ile Ile Ser Tyr Leu Asn Lys Tyr Pro 
    290                 295                 300                 


Ile His Trp Asn Lys His Leu Glu Leu Glu Ser Gly Phe Pro Gln Met 
305                 310                 315                 320 


Thr Glu Leu Leu Gln Lys Lys Ile Ile Glu Thr Glu Ile Phe Arg Ser 
                325                 330                 335     


Phe Pro Lys Tyr Asp Gln Lys Arg Glu Arg Lys Lys Phe Leu Gln Phe 
            340                 345                 350         


Ala Thr Lys Lys Leu Phe Gly Phe Asp Phe Tyr Leu Asn Glu Lys Leu 
        355                 360                 365             


Glu Phe Thr Asp Gln Glu Ile Ser Asp Phe Lys Tyr Gln Ile Asn Thr 
    370                 375                 380                 


Ser Pro Glu Leu Gln Lys Val Asn Ser Asp Ile Asp Lys Leu Gln Gly 
385                 390                 395                 400 


Thr Pro Asn Leu Ser Glu Lys Gln Asn Arg Glu Phe Arg Lys Leu Lys 
                405                 410                 415     


Gly Lys Lys Lys Lys Leu Asn Gln Phe Pro Asn Pro Val Lys Glu Lys 
            420                 425                 430         


Leu Glu Lys Arg Ile Lys Glu Lys Thr Leu Tyr Lys Ser Tyr Gly Arg 
        435                 440                 445             


Asn Gln Asp Arg Phe Met His Phe Ala Ile Arg Phe Leu Ala Glu Gly 
    450                 455                 460                 


Asn Tyr Phe Gly Glu Asp Val Lys Phe Lys Leu Tyr Gln Phe Tyr Thr 
465                 470                 475                 480 


Ile Lys Glu Gln Glu Asp Tyr Leu Thr Asp Leu Gln Asn Arg Asn Gly 
                485                 490                 495     


Leu Lys Ser Leu Asp Ser Leu Thr Tyr His Gln Gly Lys Leu Ile His 
            500                 505                 510         


Tyr Asn Thr Phe Arg Asp His Ile Asn Lys Tyr Lys Glu Trp Asp Thr 
        515                 520                 525             


Pro Phe Val Ile Gln Asn Asn Ala Phe Lys Leu Lys Ile Lys Leu Tyr 
    530                 535                 540                 


Asn Gly Thr Glu Lys Leu Leu Thr Val Gln Arg Gly Leu Met Ile Tyr 
545                 550                 555                 560 


Phe Leu Glu His Ala Leu Phe His Val Lys Ser Glu Leu His Ser Ala 
                565                 570                 575     


Gly Lys Cys Leu Leu Glu Glu Tyr Phe Glu Glu Tyr Gln Lys Glu Val 
            580                 585                 590         


Ser Tyr Gly Lys Lys Ile Leu Glu Asn Lys Glu Ala Val Ser Leu Asn 
        595                 600                 605             


Glu Lys Asn Lys Leu Lys Arg Phe Phe Pro Lys Arg Leu Leu His His 
    610                 615                 620                 


Tyr Ser Pro Thr Gln Gln Asn Asn Leu Ala Asp Lys Ser Ser Phe Glu 
625                 630                 635                 640 


Leu Ile Leu Glu Glu Ala Ile Leu Gln Glu Lys Arg Tyr Asn Glu Leu 
                645                 650                 655     


Leu Glu Asn Ala Arg Asn Val Asn Leu Glu Glu Gln Phe Thr Glu Lys 
            660                 665                 670         


Asn Lys Gly Lys Gln Phe Lys Leu Arg Phe Ile Arg Lys Ala Trp Gln 
        675                 680                 685             


Gln Met Tyr Phe Lys Ser Ile Tyr Leu Glu Arg Ala Ser Glu Lys Gly 
    690                 695                 700                 


His His Lys Ala Phe Asn Ile Thr Lys Glu Gln Phe Asn Asp Phe Ser 
705                 710                 715                 720 


Arg Trp Met Phe Ala Phe Asp Glu Val Pro Lys Tyr Lys Asp Tyr Leu 
                725                 730                 735     


Thr Ser Leu Phe Glu Gln Lys Glu Phe Phe Lys Asn Asp Glu Phe Lys 
            740                 745                 750         


His Leu Phe Asn Gln Ser Ser Ser Leu Asn Glu Leu Tyr Gly Lys Thr 
        755                 760                 765             


Lys Glu Arg Tyr Ser Asn Trp Leu Lys Ser Asn Gln Pro Gln Leu Asn 
    770                 775                 780                 


Ser Glu Lys Tyr Thr Tyr Asp Asn Tyr Lys Asn Ile Leu His Lys Asn 
785                 790                 795                 800 


Gln Trp Tyr Ile Asn Val Ala His Phe Ile Asp Phe Leu Gln Ala Lys 
                805                 810                 815     


Asp Leu Leu Tyr Lys Asn Gly Asp Asn Thr Ile Gln Tyr Lys Ala Leu 
            820                 825                 830         


Glu Asn Lys Gln Tyr Leu Val Glu Ala Tyr Tyr Tyr Lys Asp Arg Leu 
        835                 840                 845             


Asn Pro Gln Glu Tyr Lys Thr Asn Gly Lys Leu Phe Asn Lys Leu Arg 
    850                 855                 860                 


Lys Asn Lys Leu Glu Asp Ala Leu Leu Tyr Glu Met Ala Ile Arg Tyr 
865                 870                 875                 880 


Leu His Val Asp Met Ser Ile Ala Arg Glu Ala Lys Asn His Val Ser 
                885                 890                 895     


Glu Val Leu Asn Ser Asn Ile Thr Phe Asn Ile Gln Asn Lys Thr Ser 
            900                 905                 910         


Gln His Leu Tyr Lys Leu Ile Val Pro Phe Ser Lys Leu Glu Thr Leu 
        915                 920                 925             


Ala Val Leu Leu Asn His Lys Ile Glu Gln Glu Glu Ser Pro Lys Leu 
    930                 935                 940                 


Arg Gly Lys Ser Phe Leu Gly Asn Ile His Glu Tyr Leu Asn Thr Thr 
945                 950                 955                 960 


Asn Asn Asn Lys Asp Leu Lys Ala Val Ile Lys Gln Lys Lys Asn Thr 
                965                 970                 975     


Gly Thr Leu Asn Tyr Glu His Leu Asn Thr Val Tyr Asn His Ile Ile 
            980                 985                 990         


Ser Gln Ser Ile Leu Phe Thr Arg  Ile Glu Met Lys Leu  Glu Glu Tyr 
        995                 1000                 1005             


Phe Ile  Ala Lys Tyr Lys Asn  Thr Ile Pro Asp Asn  Ser Asn His 
    1010                 1015                 1020             


Ile Lys  Trp Asp Glu Ile Ile  Asn Thr Asp Asn Glu  Arg Leu Leu 
    1025                 1030                 1035             


Arg Gln  Tyr Phe Asn Lys Ala  Thr Arg Asn Lys Ala  Phe His Phe 
    1040                 1045                 1050             


Gly Ile  Pro Ser Lys Asp Tyr  Lys Lys Leu Ile Glu  Asp Glu Ile 
    1055                 1060                 1065             


Glu Ile  Lys Phe Leu Asn Glu  Glu Ile Lys Arg Asp  His Pro Thr 
    1070                 1075                 1080             


Ser Phe  Asp Asp Leu Asn Pro  Met Gln Lys Ser Val  Cys Arg Leu 
    1085                 1090                 1095             


Phe Met  Asn Val Leu His Asn  Asp Tyr Phe Arg Lys  Ser Arg Pro 
    1100                 1105                 1110             


Val Asn  Thr Glu Thr Asp Glu  Glu Lys Asn Asn Arg  Ile Arg Glu 
    1115                 1120                 1125             


Glu Arg  Ala Lys Phe Glu Glu  Thr Tyr Phe Asn Ser  Met Ile Arg 
    1130                 1135                 1140             


<210>  2096
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2096

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2097
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2097

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Lys Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Leu Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2098
<211>  1150
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2098

Met Asn Thr Gln Pro Val Gly Leu Gly Ile Ser Tyr Ser His Thr Ser 
1               5                   10                  15      


Lys Asn Asp Lys His Phe Phe Gly Gly Phe Leu Asn Leu Gly Ile Asn 
            20                  25                  30          


Asn Leu Glu Val Leu Ile Ala Ala Phe Lys Leu Lys Phe Phe Ser Gly 
        35                  40                  45              


Asp Gln Lys Lys Ile Asp Ile Lys Asn Phe Val Gln Thr Cys Phe Thr 
    50                  55                  60                  


Ala Asn Ile Ser Asp His Asp Phe Glu Ser Arg Val Glu Phe Leu Gln 
65                  70                  75                  80  


Asn Tyr Leu Pro Val Val Arg Tyr Leu Asp Lys Arg Asn Lys Glu Gly 
                85                  90                  95      


Phe Lys Asn Gln Val Glu Leu Leu Phe Lys Ser Leu Asp Ser Leu Arg 
            100                 105                 110         


Asn Phe Tyr Thr His Tyr Tyr His Ala Pro Leu Ser Leu Pro Gln Ala 
        115                 120                 125             


Leu Phe Asp Leu Leu Asp Ser Thr Phe Ala Lys Val Ala Ser Asp Val 
    130                 135                 140                 


Lys Ala Asn Lys Val Lys Asp Asp Lys Ser Arg His Leu Leu Lys Ser 
145                 150                 155                 160 


Ala Leu Ser Glu Glu Leu Asn Ala Arg Tyr Lys Leu Gln Leu Glu Arg 
                165                 170                 175     


Leu Lys Glu Leu Lys Ala Ser Gly Lys Lys Val Asn Leu His Asp His 
            180                 185                 190         


Asp Ala Ile Arg Asn Gly Val Leu Asn Ser Ser Phe Asn His Leu Ile 
        195                 200                 205             


Tyr Lys Asn Glu Ala Gly Asp Thr Ile Val Thr Arg Arg Tyr Ala Ala 
    210                 215                 220                 


Arg Tyr Ser Glu Ile Glu Ser Ala Glu Asn Gly Ile Thr Ile Ser Gln 
225                 230                 235                 240 


Ser Gly Leu Leu Phe Leu Ala Gly Leu Phe Leu Lys Arg Lys Glu Val 
                245                 250                 255     


Glu Asp Leu Lys Ser Arg Val Lys Gly Phe Lys Ala Lys Ile Ile Lys 
            260                 265                 270         


Glu Gly Glu Glu Asn Ile Ser Gly Leu Lys Tyr Met Ala Thr His Trp 
        275                 280                 285             


Ile Phe Ser Tyr Leu Ser Phe Lys Gln Pro Lys Gln Thr Leu Thr Asn 
    290                 295                 300                 


Asp Phe Asp Arg Glu Thr Leu Leu Leu Gln Ile Ile Asp Glu Leu Ser 
305                 310                 315                 320 


Lys Val Pro Asp Asp Val Tyr Gln Ala Phe Ser Glu Glu Thr Arg Asn 
                325                 330                 335     


Leu Phe Val Glu Asp Ile Asn Gln Tyr Leu Lys Glu Gly Asn Asp Asp 
            340                 345                 350         


Tyr Thr Leu Glu Glu Ala Gln Val Ile His Pro Val Ile Arg Lys Arg 
        355                 360                 365             


Tyr Glu Asn Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu Asp Glu Phe 
    370                 375                 380                 


Ala Gly Phe Thr Ser Leu Lys Phe Gln Val His Leu Gly Asn Tyr Ile 
385                 390                 395                 400 


His Asp Lys Arg Thr Lys His Ile Ser Gly Thr Glu Leu Gln Thr Glu 
                405                 410                 415     


Arg Arg Ile Lys Glu Arg Val Lys Val Phe Gly Lys Leu Ser Asp Ala 
            420                 425                 430         


Gln Arg Leu Lys Asn Asp Phe Phe Ala Asp Lys Ser Arg Arg Asp Gln 
        435                 440                 445             


Glu Leu Gly Trp Glu Ile Leu Pro Asn Pro Ser Tyr Val Phe Ile Glu 
    450                 455                 460                 


Asn Asn Ile Pro Ile Tyr Phe Lys Val Asp Asn Glu Val Ala Glu Ala 
465                 470                 475                 480 


Val Lys Ser Ala Lys Ala Ser Arg Lys Ser Leu Ser Pro Asp Glu Arg 
                485                 490                 495     


Lys Val Arg Ser Gly Asp Lys Ala Gln Lys His Ile Ile Leu Asn Ser 
            500                 505                 510         


Ile Ser Glu Arg Gly Leu Leu Arg Lys Asp Glu Pro Thr Ala Leu Leu 
        515                 520                 525             


Ser Leu Asn Glu Ile Pro Ala Leu Leu Tyr Glu Ile Leu Val Lys Gly 
    530                 535                 540                 


Thr Ser Pro Val Glu Ile Glu Glu Ile Leu Lys Ser Lys Ala Val Glu 
545                 550                 555                 560 


Arg Val Gln Val Ile Lys Asn Tyr Thr Pro Glu Gln Pro Leu Pro Gly 
                565                 570                 575     


Ser Gln Ile Ser Lys Arg Leu Arg Ser Asn Thr Ala Val Thr Gly Lys 
            580                 585                 590         


Gln Tyr Asn Val Asp Lys Leu Gln Gln Leu Leu Lys Lys Glu Ile Phe 
        595                 600                 605             


Leu Ala Asp Glu Lys Leu Ala Leu Ile Tyr Lys Asn Arg Val Glu Leu 
    610                 615                 620                 


His Lys Lys Ile Gly Gly Lys Val Leu Arg Asn Tyr Val Phe Gly Phe 
625                 630                 635                 640 


Ser Glu Leu Gly Arg Glu Ala Thr Trp Ile Ala Glu Asp Ile Lys Arg 
                645                 650                 655     


Phe Met Pro Leu Pro Ala Arg Arg Glu Trp Lys Gly Tyr Gln His Ser 
            660                 665                 670         


Gln Leu Gln Gln Ser Leu Ser Tyr Tyr Glu Ser Arg Pro Asn Glu Ala 
        675                 680                 685             


Phe Asn Ile Leu Lys Asp Asn Trp Asn Phe Asp Asp Gly Ala Met Leu 
    690                 695                 700                 


Trp Asn Ser Trp Ile Lys Asp Ser Phe Asn Glu Lys Phe Phe Asp Arg 
705                 710                 715                 720 


Phe Tyr Glu Arg Tyr Leu His Gly Lys Arg Lys Tyr Leu Glu Asn Phe 
                725                 730                 735     


Leu Glu Asn Ile Gln Asn Phe Ser Pro Gly Ser Asn Lys Ile Leu Glu 
            740                 745                 750         


Lys Phe Leu Cys Gln Gln Met Pro Lys Asn Phe Phe Asp Lys Arg Leu 
        755                 760                 765             


Tyr Val Leu Glu Pro Leu Glu Gln Glu Lys Asp Lys Ile Leu Ser Tyr 
    770                 775                 780                 


Pro Leu Val Phe Pro Arg Gly Leu Phe Asp Pro Ala Pro Thr Phe Ile 
785                 790                 795                 800 


Lys Gly Val Gln Val Met Glu Glu Pro Glu Arg Phe Ala Ala Trp Tyr 
                805                 810                 815     


Arg Tyr Gly Tyr Ser Pro Asp His Pro Phe Gln Arg Phe Tyr Glu Met 
            820                 825                 830         


Glu Arg Asp Tyr Thr Asp Leu Ile Asn Asp Asp Thr Glu Thr Arg Pro 
        835                 840                 845             


Asp Thr Asp Lys Asn Lys Ser Asp Phe Ser Ser Glu Gln Gln Tyr Ala 
    850                 855                 860                 


Leu Ile Lys Lys Lys Gln Asp Leu Lys Ile Lys Asn Ile Lys Ile Gln 
865                 870                 875                 880 


Asp Leu Phe Leu Lys Leu Ile Ala Glu Thr Leu Phe Ser Asp Ile Phe 
                885                 890                 895     


Asp Tyr Asp Ser Glu Ile Arg Leu Ser Asp Leu Tyr Leu Thr Gln Ala 
            900                 905                 910         


Glu Arg Ile Glu Lys Glu Gln Asn Ala Ala Gln Gln Ser Ile Arg Pro 
        915                 920                 925             


Ala Gly Asp Asp Ser Asp Asn Ile Ile Lys Asp Asn Phe Ile Trp Ser 
    930                 935                 940                 


Lys Thr Ile Pro Tyr Ile Lys Asp Gln Ile Tyr Glu Pro Ala Val Lys 
945                 950                 955                 960 


Phe Lys Asp Ile Gly Lys Phe Lys Tyr Phe Leu Asn Asp Gly Arg Ile 
                965                 970                 975     


Asn Arg Leu Leu Ser Tyr Asp Thr Leu Lys Ile Trp Ser Lys Ala Glu 
            980                 985                 990         


Ile Glu Thr Glu Ile Tyr Ile Gly  Ser Ala Ser Tyr Glu  Ser Ile Arg 
        995                 1000                 1005             


Arg Glu  Ala Ile Phe Lys Glu  Leu Gln Lys Leu Glu  Glu Lys Ile 
    1010                 1015                 1020             


Leu Ala  Arg Tyr Lys Gly Gly  His Pro Glu Glu Leu  Glu Tyr Lys 
    1025                 1030                 1035             


Asn Asn  Pro Ser Phe Lys Lys  Tyr Ile Val Asn Gly  Ile Leu Arg 
    1040                 1045                 1050             


Lys Lys  Pro Asp Thr Val Ser  Glu Thr Asp Cys Phe  Trp Leu Asp 
    1055                 1060                 1065             


Asn Phe  Asp Glu Ser Thr Phe  Glu Asn Pro Glu Val  Phe Glu Ile 
    1070                 1075                 1080             


Leu Ser  Asp Lys Leu Pro Leu  Val Gln Glu Ala Phe  Leu Leu Val 
    1085                 1090                 1095             


Tyr Leu  Arg Asn Lys Phe Ala  His Asn Gln Leu Pro  Ile Lys Glu 
    1100                 1105                 1110             


Ala Tyr  Phe Tyr Ile Asn Glu  Asn Tyr Pro Asp Leu  Arg Gly Ser 
    1115                 1120                 1125             


Thr Val  Ser Glu Thr Leu Leu  Asn Phe Leu Val His  Ala Val Asn 
    1130                 1135                 1140             


Asn Ile  Thr Asn Arg Cys Ile  
    1145                 1150 


<210>  2099
<211>  985
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2099

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Asn Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys Gly Tyr 
                165                 170                 175     


Ala Phe Phe Ile Ser Lys Phe Leu Glu Arg Lys Tyr Ser Tyr Leu Phe 
            180                 185                 190         


Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln Tyr Arg 
        195                 200                 205             


Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro Val Glu 
    210                 215                 220                 


Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu Asp Ile 
225                 230                 235                 240 


Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr Leu Glu 
                245                 250                 255     


Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr Asp Ala 
            260                 265                 270         


Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe Arg Ser 
        275                 280                 285             


Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala Asp Phe 
    290                 295                 300                 


Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His Asn Gly 
305                 310                 315                 320 


Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr Ile Asn 
                325                 330                 335     


Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser Ala Lys 
            340                 345                 350         


Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser Thr Asp 
        355                 360                 365             


Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln Ser Thr 
    370                 375                 380                 


Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val Leu Pro 
385                 390                 395                 400 


Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala Lys Met 
                405                 410                 415     


Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala Met Leu 
            420                 425                 430         


Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His Cys Pro 
        435                 440                 445             


Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser Thr Lys 
    450                 455                 460                 


Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg Val Met 
465                 470                 475                 480 


Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu Arg Ile 
                485                 490                 495     


Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile Leu Lys 
            500                 505                 510         


Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp Leu Gln 
        515                 520                 525             


Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn Phe Gln 
    530                 535                 540                 


Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn Asp Leu 
545                 550                 555                 560 


Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn Pro His 
                565                 570                 575     


Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile Glu Phe 
            580                 585                 590         


Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg Ile Gln 
        595                 600                 605             


Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro Leu Arg 
    610                 615                 620                 


Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu Ala Ile 
625                 630                 635                 640 


Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys Leu Lys 
                645                 650                 655     


Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu Lys Ser 
            660                 665                 670         


Pro Ala Leu Asn Val Ser Tyr Leu Ile His Asn Tyr Phe Arg Ala Tyr 
        675                 680                 685             


Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn Tyr Arg 
    690                 695                 700                 


Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser Tyr Leu 
705                 710                 715                 720 


Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro Ser Lys 
                725                 730                 735     


Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp Arg Leu 
            740                 745                 750         


Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile Ile Arg 
        755                 760                 765             


Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys Glu Tyr 
    770                 775                 780                 


Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu Glu Asn 
785                 790                 795                 800 


Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp Leu Asn 
                805                 810                 815     


Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr Gly Lys 
            820                 825                 830         


Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn Lys Val 
        835                 840                 845             


Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val Lys Ile 
    850                 855                 860                 


Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu Glu Ala 
865                 870                 875                 880 


Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala Met Val 
                885                 890                 895     


Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr Tyr Asp 
            900                 905                 910         


Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln Lys Ile 
        915                 920                 925             


Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His Asp Lys 
    930                 935                 940                 


Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val Tyr Ala 
945                 950                 955                 960 


Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile Lys Leu 
                965                 970                 975     


Glu Asp Leu Ser Asn Asp Ser Ser Ala 
            980                 985 


<210>  2100
<211>  1121
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2100

Val Lys Met Glu Asp Asp Lys Lys Thr Thr Gly Ser Ile Ser Tyr Glu 
1               5                   10                  15      


Leu Lys Asp Lys His Phe Gly Ala Ala Phe Leu Asn Leu Ala Arg His 
            20                  25                  30          


Asn Val Tyr Ile Thr Ile Asn His Ile Asn Lys Leu Leu Glu Ile Arg 
        35                  40                  45              


Glu Ile Asp Asn Asp Glu Lys Val Leu Asp Ile Lys Ala Leu Trp Gln 
    50                  55                  60                  


Lys Gly Asn Lys Asp Leu Asn Gln Lys Ala Arg Leu Arg Glu Leu Met 
65                  70                  75                  80  


Thr Lys His Phe Pro Phe Leu Glu Thr Ala Ile Tyr Ser Lys Asn Lys 
                85                  90                  95      


Glu Asp Lys Glu Glu Val Lys Gln Glu Lys Gln Ala Glu Ala Gln Ser 
            100                 105                 110         


Leu Glu Ser Leu Lys Asp Cys Leu Phe Leu Phe Leu Glu Lys Leu Gln 
        115                 120                 125             


Glu Ala Arg Asn Tyr Tyr Ser His Tyr Lys Tyr Ser Glu Phe Ser Lys 
    130                 135                 140                 


Glu Pro Glu Phe Glu Glu Gly Leu Leu Glu Lys Ile Tyr Asn Ile Phe 
145                 150                 155                 160 


Asp Asp Asn Ile Gln Leu Val Ile Lys Asp Tyr Gln His Asn Lys Asp 
                165                 170                 175     


Ile Asn Pro Asp Glu Asp Phe Lys His Leu Asp Arg Thr Glu Glu Asp 
            180                 185                 190         


Phe Asn Tyr Tyr Phe Thr Arg Asn Lys Lys Gly Asn Ile Thr Ala Ser 
        195                 200                 205             


Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile 
    210                 215                 220                 


Trp Met Gln Gln Lys Leu Arg Gly Phe Lys Asp Asn Arg Glu Ser Lys 
225                 230                 235                 240 


Lys Lys Met Thr His Glu Val Phe Cys Arg Ser Arg Met Leu Leu Pro 
                245                 250                 255     


Lys Leu Arg Leu Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp 
            260                 265                 270         


Met Leu Asn Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu 
        275                 280                 285             


Gln Gly Asp Asp Arg Glu Lys Phe Lys Val Pro Phe Asp Pro Ala Asp 
    290                 295                 300                 


Glu Asp Tyr Asp Ala Glu Gln Glu Pro Phe Lys Asn Thr Leu Val Arg 
305                 310                 315                 320 


His Gln Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Tyr Asn 
                325                 330                 335     


Glu Ile Phe Thr Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His 
            340                 345                 350         


Phe Ser Ile Tyr Lys Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg His 
        355                 360                 365             


Leu Thr His Lys Leu Tyr Gly Phe Glu Arg Ile Gln Glu Phe Ala Lys 
    370                 375                 380                 


Gln Asn Arg Pro Asp Glu Trp Lys Ala Ile Val Lys Asp Phe Asp Thr 
385                 390                 395                 400 


Tyr Glu Thr Ser Asn Glu Arg Tyr Ile Ser Glu Thr Thr Pro His Tyr 
                405                 410                 415     


His Leu Glu Asn Gln Lys Ile Gly Ile Arg Phe Arg Asn Gly Asn Lys 
            420                 425                 430         


Asp Ile Trp Pro Ser Leu Lys Thr Asn Gly Glu Asn Asn Glu Lys Arg 
        435                 440                 445             


Lys Tyr Lys Leu Asp Lys Gln Tyr Gln Ala Glu Ala Phe Leu Ser Val 
    450                 455                 460                 


His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Lys Lys Glu 
465                 470                 475                 480 


Glu Pro Asn Asn Asp Lys Lys Asn Ala Ser Ile Val Glu Gly Phe Ile 
                485                 490                 495     


Lys Arg Glu Ile Arg Asp Ile Tyr Lys Leu Tyr Asp Ala Phe Ala Asn 
            500                 505                 510         


Gly Glu Ile Asn Asn Ile Asp Asp Leu Glu Lys Tyr Cys Glu Asp Lys 
        515                 520                 525             


Gly Ile Pro Lys Arg His Leu Pro Lys Gln Met Val Ala Ile Leu Tyr 
    530                 535                 540                 


Asp Glu Pro Lys Asp Met Val Lys Glu Ala Lys Arg Lys Gln Lys Glu 
545                 550                 555                 560 


Met Val Lys Asp Thr Lys Lys Leu Leu Ala Thr Leu Glu Lys Gln Thr 
                565                 570                 575     


Gln Gly Glu Ile Glu Asp Gly Gly Arg Asn Ile Arg Leu Leu Lys Ser 
            580                 585                 590         


Gly Glu Ile Ala Arg Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro 
        595                 600                 605             


Val Gln Lys Asp Asn Glu Gly Asn Pro Leu Asn Asn Ser Lys Ala Asn 
    610                 615                 620                 


Ser Thr Glu Tyr Gln Met Leu Gln Arg Ser Leu Ala Leu Tyr Asn Lys 
625                 630                 635                 640 


Glu Glu Lys Pro Thr Arg Tyr Phe Arg Gln Val Asn Leu Ile Asn Ser 
                645                 650                 655     


Ser Asn Pro His Pro Phe Leu Lys Trp Thr Lys Trp Glu Glu Cys Asn 
            660                 665                 670         


Asn Ile Leu Ser Phe Tyr Arg Ser Tyr Leu Thr Lys Lys Ile Glu Phe 
        675                 680                 685             


Leu Asn Lys Leu Lys Pro Glu Asp Trp Glu Lys Asn Gln Tyr Phe Leu 
    690                 695                 700                 


Lys Leu Lys Glu Pro Lys Thr Asn Arg Glu Thr Leu Val Gln Gly Trp 
705                 710                 715                 720 


Lys Asn Gly Phe Asn Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg 
                725                 730                 735     


Glu Trp Phe Lys Arg His Gln Asn Asp Ser Lys Glu Tyr Glu Lys Val 
            740                 745                 750         


Glu Ala Leu Lys Arg Val Gly Leu Val Thr Lys Val Ile Pro Leu Phe 
        755                 760                 765             


Phe Lys Glu Glu Tyr Phe Lys Glu Asp Ala Gln Lys Glu Ile Asn Asn 
    770                 775                 780                 


Cys Val Gln Pro Phe Tyr Ser Leu Pro Tyr Asn Val Gly Asn Ile His 
785                 790                 795                 800 


Lys Pro Asp Glu Glu Asp Phe Leu His Arg Glu Glu Arg Ile Glu Leu 
                805                 810                 815     


Trp Gly Lys Lys Lys Asp Lys Phe Lys Gly Tyr Lys Ala Lys Val Lys 
            820                 825                 830         


Ser Lys Lys Leu Thr Asp Lys Glu Lys Glu Glu Tyr Arg Ser Tyr Leu 
        835                 840                 845             


Glu Phe Gln Ser Trp Asn Lys Phe Glu Arg Glu Leu Arg Leu Val Arg 
    850                 855                 860                 


Asn Gln Asp Ile Val Thr Trp Leu Leu Cys Thr Glu Leu Ile Asp Lys 
865                 870                 875                 880 


Leu Lys Val Glu Gly Leu Asn Val Glu Glu Leu Lys Lys Leu Arg Leu 
                885                 890                 895     


Lys Asp Ile Asp Thr Asp Thr Ala Lys Gln Glu Lys Asn Asn Ile Leu 
            900                 905                 910         


Asn Arg Ile Met Pro Met Gln Leu Pro Val Thr Val Tyr Glu Ile Asp 
        915                 920                 925             


Asp Ser His Asn Ile Val Lys Asp Arg Pro Leu His Thr Val Tyr Ile 
    930                 935                 940                 


Glu Glu Thr Lys Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu 
945                 950                 955                 960 


Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Val Asp Thr Ser 
                965                 970                 975     


Ser Glu Ala Glu Leu Lys Ser Asn Pro Ile Ser Lys Ser Val Val Glu 
            980                 985                 990         


Tyr Glu Leu Gly Glu Tyr Gln Asn  Ala Arg Ile Glu Thr  Ile Lys Asp 
        995                 1000                 1005             


Met Leu  Leu Leu Glu Lys Thr  Leu Ile Lys Lys Tyr  Lys Thr Leu 
    1010                 1015                 1020             


Pro Thr  Asn Lys Phe Ser Ala  Met Leu Asn Gly Trp  Leu Glu Gly 
    1025                 1030                 1035             


Lys Asp  Glu Ser Asp Lys Ala  Arg Phe Gln Asn Asp  Val Lys Leu 
    1040                 1045                 1050             


Leu Val  Ala Val Arg Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met 
    1055                 1060                 1065             


Arg Asn  Arg Ile Ala Phe Ala  Asn Ile Asn Pro Phe  Ser Leu Ser 
    1070                 1075                 1080             


Ser Ala  Asp Ile Ser Glu Glu  Lys Gly Leu Asn Ile  Ala Asn Gln 
    1085                 1090                 1095             


Leu Lys  Asp Lys Thr His Lys  Thr Ile Lys Lys Ile  Ile Glu Ile 
    1100                 1105                 1110             


Glu Lys  Pro Ile Glu Thr Lys  Glu 
    1115                 1120     


<210>  2101
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2101

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Met Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Met Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2102
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2102

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2103
<211>  1047
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2103

Met Glu Glu Gln Phe Leu Gln Lys Glu Arg Asn Met Gly Asp Asn Pro 
1               5                   10                  15      


Tyr Tyr Phe Cys His Phe Ile Asn Met Ala His His Asn Val Asn Leu 
            20                  25                  30          


Ile Leu Glu Glu Ile Tyr Asn Ser Val Tyr Glu Lys Tyr Thr Gln Asp 
        35                  40                  45              


Lys Glu Glu Asn Ile Lys Ala Ile Cys Asn Ser Met Ile Ser Lys Ser 
    50                  55                  60                  


Arg Lys Asn Pro Asp Glu Lys Ala Lys Met Met Asn Met Cys Ile Arg 
65                  70                  75                  80  


His Phe Pro Phe Leu Asp Tyr Tyr Lys Glu Lys Asp Gln Asn Ser Asp 
                85                  90                  95      


Val Leu Thr Ile Leu Leu Asn Gln Phe Leu Val Pro Leu His Gly Leu 
            100                 105                 110         


Arg Asn Gln Phe Ser His Tyr Lys His Pro Gln Glu Ala Tyr Cys Ile 
        115                 120                 125             


Ser Gly Phe Asp Leu Leu Phe Glu Gln Ala Lys Thr Gly Ala Gln Met 
    130                 135                 140                 


Arg Met Lys Tyr Ser Asp Glu Asp Ile Ser Lys Val Lys Ser Lys Val 
145                 150                 155                 160 


Val Asn His Asp Ser Ile Leu Thr Glu Arg Gly Ile Leu Phe Phe Ile 
                165                 170                 175     


Cys Leu Phe Leu Asp Lys Arg Asn Ile Tyr Leu Phe Leu Ser Lys Ile 
            180                 185                 190         


Lys Gly Phe Arg Asp Arg Arg Pro Asp Glu Lys Tyr Lys Ser Ala Thr 
        195                 200                 205             


Leu Glu Val Phe Ser Gln Tyr Tyr Cys His Val Pro Tyr Arg Lys Leu 
    210                 215                 220                 


Asp Ser Ser Asp Val Ala Leu Asp Met Leu Asn Glu Leu Asn Arg Cys 
225                 230                 235                 240 


Pro Lys Ala Leu Tyr Asp Val Leu Ser Asp Glu Asp Arg Glu Arg Phe 
                245                 250                 255     


Ile Val Asp Asn Val Glu Asn Ala Asp Asn Arg Asp Glu Ile Ser Asp 
            260                 265                 270         


Glu Asp Asp Glu Glu Met Pro Arg Ser Val Met Lys Arg Ser Asp Asp 
        275                 280                 285             


Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Glu Lys Gln Asn Asn Leu 
    290                 295                 300                 


Asp Glu Ile Ser Phe His Leu Tyr Leu Gly Arg Lys Glu Ala Lys Pro 
305                 310                 315                 320 


Ala His Glu Lys Val Ile Asn Gly Glu Met Arg Thr His Lys Ile Leu 
                325                 330                 335     


Lys Asp Ile His Val Phe Gly Arg Leu Glu Asn Tyr Arg Asn Glu Glu 
            340                 345                 350         


Ile Cys Asn Ala Ile Lys Asn Arg Glu Asp Ile Glu Phe Tyr Ala Pro 
        355                 360                 365             


Ser Tyr Arg Ile Val Glu Asn Arg Ile Gly Leu Leu Leu Arg Arg Gln 
    370                 375                 380                 


Asn Asp Phe Thr Leu Glu Glu Ala Asn Glu Glu Lys Ile Phe Glu Gly 
385                 390                 395                 400 


Asn Leu Cys Pro Asp Val Ile Leu Ser Thr His Glu Leu Gly Ala Leu 
                405                 410                 415     


Phe Phe Tyr Asn Tyr Leu His Lys Lys Gly Trp Ile Glu Ser Ala Pro 
            420                 425                 430         


Tyr Leu Tyr Ile Arg Asn Phe Ile Ser Asp Phe Lys Arg Phe Ile Glu 
        435                 440                 445             


Asp Ile Lys Asn Gly Lys Leu Thr Pro Val Glu Ser Glu Asp Asp Phe 
    450                 455                 460                 


Tyr Leu Ile Lys Lys Lys Lys Arg Asp Glu Thr Lys Asp Asn Asp Lys 
465                 470                 475                 480 


Lys Ser Ile Ala Val Gln Glu Arg Arg Arg Glu Lys Leu Lys Glu Lys 
                485                 490                 495     


Leu Lys Gly Tyr His Leu Glu Pro Asp Trp Ile Pro Asp Ala Cys Arg 
            500                 505                 510         


Glu Tyr Met Leu Gly Tyr Lys Ala Asp Gln Lys Asp Tyr Tyr Thr Lys 
        515                 520                 525             


Gln Arg Phe Cys Ser Met Lys Lys Glu Thr Asp Ser Arg Ile Lys Gln 
    530                 535                 540                 


Ile Glu Ala Ile Arg Lys Arg Glu Asp Asn Ser Ile Ile Arg Gln Thr 
545                 550                 555                 560 


Arg Val Gly Glu Ile Ala Gln Glu Leu Ala Arg Asp Ile Val Phe Leu 
                565                 570                 575     


Ile Pro Pro Tyr Lys Asn Glu Lys Gly Ala Asp Thr Lys Ile Asn Asn 
            580                 585                 590         


Met Glu Phe Asp Val Leu Gln Lys Met Leu Ala Tyr Phe Pro Leu Asn 
        595                 600                 605             


Lys Lys Asp Ile Tyr Pro Phe Leu Lys Asn Ile Arg Asn Trp Asp Lys 
    610                 615                 620                 


His Pro Phe Leu Lys Tyr Thr Leu His Thr Glu His Gln Ser Leu Leu 
625                 630                 635                 640 


Asp Phe Tyr Gln Asp Tyr Leu Asn Cys Lys Lys Arg Trp Ile Ser Lys 
                645                 650                 655     


Asn Ile Arg Tyr Asp Lys Gln Lys Gly Asn Tyr Leu Val Asp Ala Asn 
            660                 665                 670         


Lys Thr Glu Gln Glu Cys Arg Tyr Phe Leu Lys Thr Asp Lys Leu Arg 
        675                 680                 685             


Thr Ala Lys Glu Lys Glu Tyr Phe Glu Glu Pro Asp Lys Pro Val Tyr 
    690                 695                 700                 


Leu Pro Thr Gly Phe Phe Val Asp Pro Ile Val Glu Ala Met Arg Lys 
705                 710                 715                 720 


Asn Gly Tyr Glu Leu Lys Glu Asn Ser Asn Ile Val Gly Cys Leu Lys 
                725                 730                 735     


Ile Tyr Phe Val Ser Lys Ile Gln Pro Met Tyr Asp Leu Ser Arg Tyr 
            740                 745                 750         


Tyr Thr Tyr Tyr Asp Gly Lys Glu Glu Arg Ser Met Gln Leu Asp Asp 
        755                 760                 765             


Leu Lys Val Phe Ile Lys Glu Lys Phe Gly Asn Lys Arg Thr Asp Asp 
    770                 775                 780                 


Asn Thr Ile Arg Phe Leu Lys Lys Ala Ala Lys Arg Ile Arg Glu Asn 
785                 790                 795                 800 


Glu Ser Glu Ile Leu Val Arg Gln Met Asp Asp Cys Ala Leu Phe Leu 
                805                 810                 815     


Met Val Asn Asp Leu Leu Glu Gly Gly Lys Phe Asn Asp Glu Asp Ile 
            820                 825                 830         


Glu Asn Ile Gly Tyr Asn Lys His His Asn Leu Leu Asp His Glu Tyr 
        835                 840                 845             


Asp Met Cys Glu Thr Ile Tyr Gly Arg Lys Val Thr Ala Arg Leu Pro 
    850                 855                 860                 


Ile Lys Arg Tyr Gly Glu Phe Arg Arg Phe Met Lys Asp Arg Arg Leu 
865                 870                 875                 880 


Gln Asn Leu Val Lys Tyr Tyr Pro Gly Asp His Glu Thr Pro Ile Pro 
                885                 890                 895     


Ser Gly Ile Pro Glu Ser Gly Lys Ala Met Glu Lys Asn Lys Lys Tyr 
            900                 905                 910         


Thr Tyr Ser Asn Leu Cys Asp Glu Leu Glu Ile Tyr Asp Lys Glu Arg 
        915                 920                 925             


Asp Asn Val Leu Asn Leu Ile Tyr Glu Val Asp Lys Ile Leu Val Asp 
    930                 935                 940                 


His Phe Pro Asp Lys Ile Met Lys Glu Glu Asp Gly Tyr Tyr Glu His 
945                 950                 955                 960 


Tyr His Cys Leu Asp Phe Ala Lys Lys Glu Phe Gly Leu Glu Ser Asp 
                965                 970                 975     


Val Glu Leu Leu Ser Gln Asp Asn Phe Lys Asp Leu Arg Asn Ala Leu 
            980                 985                 990         


Tyr His Asn Gln Ile Pro Tyr Asn  Asp Trp Val Ala Asp  Lys Ile Ser 
        995                 1000                 1005             


Lys Asp  Thr Glu Glu Pro Met  Tyr Val Arg Arg Ile  Phe Ser Phe 
    1010                 1015                 1020             


Ile Arg  Thr Val Tyr Ser Arg  Leu Leu Asp Gln Ile  Lys Ile Lys 
    1025                 1030                 1035             


Ile Glu  Lys Asp Glu Tyr Lys  Cys Lys 
    1040                 1045         


<210>  2104
<211>  1140
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2104

Met Glu Asn Asp Gln Gln Ile Leu Glu Asn Arg Arg Arg Thr Leu Ala 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Ser Asn His Leu Ala Ala Ser Phe Glu Gln Lys Val 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ala Ser Phe Leu Cys Asn Lys Ser 
    50                  55                  60                  


Ile Lys Lys Ile Asn Trp Asn His Val Tyr Ser Lys Ala Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ala Asp Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Arg Glu Thr Thr Asp Lys Glu Gly Lys Asp Phe Thr Ala Met Asn Glu 
            100                 105                 110         


Thr Leu Lys Leu Val Phe Asp Glu Leu Gln Ala Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Ala Asp Ser Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Val Glu Leu Ala Asp Phe Leu Thr Val Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Ala Asp Asp Asp Tyr 
                165                 170                 175     


Thr Met Val Glu Ser Lys Gln Ile Val Thr Pro Asp Asn Leu Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Val Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Leu Ala Tyr Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asp Leu Gly Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Glu 
            260                 265                 270         


Val Ile Thr Glu Glu Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Glu Glu Glu Arg 
    290                 295                 300                 


Glu Lys Ile Leu Asp Glu Ile Asp Tyr Glu Asp Tyr Ile Glu Ser Leu 
305                 310                 315                 320 


Thr Arg Arg Val Arg His Ser Asn Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Lys Tyr Asn Lys Gln Phe Asp Gly Glu 
        355                 360                 365             


Ala Thr Glu Cys Lys Val Val Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asn Gln Glu Thr Val Glu Leu Lys Ile Asp Ser Ala 
385                 390                 395                 400 


Gln Arg Thr Asn Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Glu Ala Arg Leu Leu 
            420                 425                 430         


Thr Lys Ala Lys Pro Glu Ser Lys Val Ser Tyr Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Lys Ala Glu Glu Met Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Lys Val Asn Asp Ser Gln Leu Met Ser Met Gln Phe Ile Asp Glu 
                485                 490                 495     


Ile Lys Glu Gln Leu Pro Ala Asp Trp Asn Glu Phe Gly Lys Arg Ser 
            500                 505                 510         


Asp Ser Lys Lys Lys Lys Ala Tyr Thr Asn Ala Ala Leu Gln Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Lys Val Leu Ala Asn Tyr Gln Leu 
    530                 535                 540                 


Asn Asp Lys Gln Val Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Ser Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Val Glu Lys His Lys Leu 
            580                 585                 590         


Asp Lys Ser Ala Arg Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Thr Asp Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Phe Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Tyr 
625                 630                 635                 640 


Ala Asp Thr Asp Lys Lys Ala Thr Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Lys Gly Gly His Pro Phe Leu Ala Asn Ile Asn 
            660                 665                 670         


Leu Arg Gln Ile Arg Lys Thr Ser Gln Leu Tyr Glu Leu Tyr Leu Val 
        675                 680                 685             


Glu Lys Ala Asn Lys Gln Val Lys Lys Met Asn Pro Lys Thr Gln Arg 
    690                 695                 700                 


Thr Ser Asn Val Asp Glu Ser Trp Met Met Lys Ser Phe Tyr Ala Lys 
705                 710                 715                 720 


Glu Trp Asn Glu Glu Met Gly Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Val Asn Lys Thr Asn Ile Pro Phe Thr Ile Arg Gln Trp Glu Glu Lys 
            740                 745                 750         


Glu Lys His Asn Leu Gln Ala Trp Leu His Asn Ile Thr Lys Gly Lys 
        755                 760                 765             


Thr Ser Lys Asp Gly Lys Lys Ala Ile Asp Leu Pro Thr Asn Leu Phe 
    770                 775                 780                 


Asp Asp Thr Leu Cys Glu Leu Leu Arg Glu Ala Leu Ile Asn Gln Gly 
785                 790                 795                 800 


Ile Asp Ala Thr Pro Thr Thr Lys Tyr Asn Glu Leu Leu Lys Gln Trp 
                805                 810                 815     


Trp Thr Ala Arg Glu Asp Ser Thr Gln Asp Phe Tyr Leu Ser Glu Arg 
            820                 825                 830         


Gln Tyr Asp Ile Tyr Asp Glu Lys Val Cys Phe Thr Ile Asn Ser Ser 
        835                 840                 845             


Ala His Phe Ala Asp Tyr Tyr Ala Pro Ala Leu Asn Lys Ala Tyr Ser 
    850                 855                 860                 


Arg Leu Arg Ala Glu Arg Asp Val Ala Arg Arg Thr Asp Lys Arg Leu 
865                 870                 875                 880 


Pro Pro Val Glu Arg Lys Asp Val Glu Arg Val Phe Lys Asn Thr Ile 
                885                 890                 895     


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
            900                 905                 910         


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asn Gln Gln Gln Leu Lys 
        915                 920                 925             


Leu Ser Lys Met Asp Ser Leu Leu Asn Glu Thr Lys Arg Ile Glu Gln 
    930                 935                 940                 


Thr Ile Asn Thr Gln Leu Ser Phe Asp His Lys Gly Lys Glu Ile Lys 
945                 950                 955                 960 


Asp Lys Thr Asn Ser Glu Ile Val Lys Thr Ile Val Ala Glu Arg Lys 
                965                 970                 975     


Gln Lys Asn Tyr Thr Glu Met Arg Lys Tyr Val His Asp Arg Arg Leu 
            980                 985                 990         


Pro Glu Leu Phe Glu Tyr Ile Asp  Gly Asn Glu Leu Pro  Leu Asp Val 
        995                 1000                 1005             


Leu Leu  Asn Glu Leu Arg Ala  Tyr Asn Thr Ala Lys  Gln Met Val 
    1010                 1015                 1020             


Phe Asp  Thr Val Phe Ala Leu  Glu Lys Lys Ile Ile  Glu Thr Asp 
    1025                 1030                 1035             


Pro Glu  Gly Leu Lys Gln Leu  Asn Val Gly Lys Asn  Gly Gln Ile 
    1040                 1045                 1050             


Gln Thr  Gly Asn Ile Gln His  Lys Pro Tyr Val Gln  Trp Leu Glu 
    1055                 1060                 1065             


Asn Lys  Gly Leu Ile Thr Asp  His Gln Lys Gln Phe  Ile Asn Met 
    1070                 1075                 1080             


Val Arg  Asn Ser Phe Ser His  Asn Gln Phe Pro Gln  Arg Ser Thr 
    1085                 1090                 1095             


Val Glu  Leu Leu Met Pro Glu  Trp Gln Asn Thr Asp  Ile Ala Leu 
    1100                 1105                 1110             


Gln Ile  Ala Arg Glu Tyr Gln  Gln Leu Ile Val Asp  Ile Ile Glu 
    1115                 1120                 1125             


Lys Ser  Leu His Pro His Lys  Gln His Gln Met Val  
    1130                 1135                 1140 


<210>  2105
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2105

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2106
<211>  1069
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2106

Met Val Tyr Tyr Asn Trp Lys Asn His Asp Glu Lys Trp Phe Phe Ala 
1               5                   10                  15      


Ile Tyr Leu Asn Leu Ala Arg Gln Asn Ala Tyr Leu Thr Leu Ser His 
            20                  25                  30          


Ile Ala Asn Leu Leu Gly Glu Val Pro Cys Asp Glu Glu Asn Leu Cys 
        35                  40                  45              


Glu Met Pro Ile Ile Glu Ala Leu Asn Gly Asn Asp Gln Ser Leu Leu 
    50                  55                  60                  


Gln Lys Ser Glu Arg Leu Ile Leu Lys His Phe Pro Phe Phe Ala Pro 
65                  70                  75                  80  


Ile Ile Glu Thr Glu Arg Asn Ile Ala Leu Lys Asn Asn Lys Pro Phe 
                85                  90                  95      


Ser Glu Lys Glu Gly Thr Lys Leu Leu Tyr Asn Leu Cys Lys Ser Phe 
            100                 105                 110         


Phe Gln Leu Leu Asn Asp Trp Arg Asn Phe Tyr Thr His Tyr Asp Tyr 
        115                 120                 125             


Ala Val Met Arg Phe Arg Asn Asp Glu Glu Arg Asp Asn Phe Phe Lys 
    130                 135                 140                 


Tyr Leu Asp Phe Ile Phe Asp Thr Ser Leu Arg Met Gly Lys Glu Arg 
145                 150                 155                 160 


Phe Lys Trp Glu Glu Asn Glu Leu Ser Cys Phe Arg Arg Leu Glu Gly 
                165                 170                 175     


Lys Asp Arg Ile Thr Arg Arg Pro Lys Glu Asn Pro Asn Phe Leu Tyr 
            180                 185                 190         


His Phe Glu Arg Glu Lys Lys Leu Thr Glu Lys Gly Phe Val Phe Phe 
        195                 200                 205             


Val Ser Leu Phe Leu Glu Lys Lys Asp Ser Ile Asp Leu Ile Asn His 
    210                 215                 220                 


Val Lys Gln His Phe Asn Asp Ile Phe Arg Asp Phe Phe Ala Ile Tyr 
225                 230                 235                 240 


Ser Ile Arg Ile Pro Gln His Arg Val Glu Ser Thr Asp Ser Thr Leu 
                245                 250                 255     


Ala Leu Gly Leu Asp Ile Leu Asn Glu Leu Lys Arg Phe Pro Lys Pro 
            260                 265                 270         


Val Phe Glu Leu Leu Gln Lys Lys Asp Lys Ile Ser Phe Ile Ser Asn 
        275                 280                 285             


Ile Lys Glu Ser Asp Gln Asn Glu Ser Asn Phe Ile Arg Met Asn Asn 
    290                 295                 300                 


Arg Phe Ala Phe Phe Ala Leu Asn Phe Ile Asp Glu Leu Lys Leu Phe 
305                 310                 315                 320 


Pro Gln Phe Arg Phe His Ile Lys Leu Gly Arg Tyr Phe Tyr Lys Phe 
                325                 330                 335     


Tyr Asp Lys Lys Thr Ile Asp Gly Glu Thr Arg Lys Arg Asn Leu Ser 
            340                 345                 350         


Val Gly Leu Lys Thr Phe Ala Arg Leu Asn Glu Val Asn Ser Ala Lys 
        355                 360                 365             


Lys Glu Gln Trp Asp Asn Leu Ile Trp Asp Glu Ala Lys Glu Lys Leu 
    370                 375                 380                 


Pro Thr Pro Pro Lys Asn Phe Ala Gln Lys Tyr Ile Thr Asn Ala Phe 
385                 390                 395                 400 


Pro Arg Tyr His Leu Asn Ala Asn Gln Ile Ala Leu Lys Lys Val Gly 
                405                 410                 415     


Asp Asn Ile His Leu Pro Glu Leu Asp Asp Gly Lys Thr His Cys Asp 
            420                 425                 430         


Val Pro Asp Cys Phe Leu Ser Ala Tyr Glu Leu Pro Ala Leu Val Phe 
        435                 440                 445             


Tyr Gly Leu Ile Leu Gly Gln Lys Asn Thr Val Asp Gly Phe Ala Ala 
    450                 455                 460                 


Ala Glu Lys Ile Ile Asp Ser His Ile Lys Asn Phe Arg Lys Leu Phe 
465                 470                 475                 480 


Ser Asp Ile His Thr Gly Glu Met Leu Pro Asp Ser Glu Glu Asn Val 
                485                 490                 495     


Lys Asn Thr Leu Asn Ser Gln Tyr Gln Ile Asp Ile Ser Asp Ile Pro 
            500                 505                 510         


Val Glu Met Gln Asp Tyr Leu Leu Asp Lys Lys Val Asn Ile Ser Glu 
        515                 520                 525             


Lys Phe Lys Lys Phe Ala Gly Asn Lys Ile Arg Asn Glu Val Glu Arg 
    530                 535                 540                 


Cys Gln Arg Leu Ile Glu Lys Ile Lys Val Lys Arg Asp Lys Leu Lys 
545                 550                 555                 560 


Asp Lys Gly Asn Lys Ile Gly Lys Lys Lys Phe Val Val Ile Lys Ser 
                565                 570                 575     


Gly Ser Leu Ala Lys Phe Leu Ala Lys Asp Met Leu Asn Leu Gln Pro 
            580                 585                 590         


Ser Leu Asp Gly Ala Gly Lys Asp Lys Ile Thr Ser Leu Asn Tyr Gln 
        595                 600                 605             


Val Leu Gln Ser Tyr Leu Thr Ser Tyr Ser Gln His Lys His Leu Leu 
    610                 615                 620                 


Lys Asn Leu Phe Leu Asn Cys Ala Leu Thr Phe Ser Lys Asn Lys His 
625                 630                 635                 640 


Pro Phe Leu Glu Lys Leu Asn Pro Glu Asn His Leu Thr Ile Val Asp 
                645                 650                 655     


Phe Phe Ile Ala Tyr Leu Ile Lys Arg Lys Glu Tyr Phe Glu Glu Cys 
            660                 665                 670         


Leu Lys Lys Ile Val Met Gly Lys Asn Val Ser Glu Tyr Phe Leu His 
        675                 680                 685             


Pro Lys Arg Lys Lys Trp Asn Val Arg Asp Thr Glu Tyr Tyr Arg Asn 
    690                 695                 700                 


Leu Ala Lys Thr Tyr Ser Glu Asn Pro Ile Ser Leu Pro Arg Gly Met 
705                 710                 715                 720 


Phe Asn Glu Gly Leu Lys Lys Trp Phe Ser Glu Asn Gly Asn Asp Lys 
                725                 730                 735     


Met Lys Lys Phe Ala Gln Gly Arg Cys Asn Ser Val Phe Leu Ile Gln 
            740                 745                 750         


Asn Tyr Phe Ala Glu Val Glu Lys Asp Lys Ser Gln Glu Phe Tyr Asn 
        755                 760                 765             


Phe Lys Arg Ser Tyr Lys Ile Leu Asn Leu Leu Leu Gly Lys Arg Ser 
    770                 775                 780                 


Gly Asn Lys Leu Leu Glu Asn Tyr Phe Ser Val Ala Glu Leu Ser Ser 
785                 790                 795                 800 


Asn Cys Lys Asn Trp Ser Gln Gln Ile Tyr Lys Leu Pro Gln Lys Pro 
                805                 810                 815     


Leu Asp Ser Arg Asn Val Glu Ile Ser Lys Leu Tyr Arg Glu Ser Ala 
            820                 825                 830         


Leu Gly Lys Phe Asn Lys Phe Leu Gln Asn Glu Lys Ile Ile Arg Phe 
        835                 840                 845             


Asn Lys Val Gln Asp Met Leu Leu Phe Leu Met Val Lys Glu Ile Phe 
    850                 855                 860                 


Thr Tyr His Gln Lys Gln Ala Asp Leu Lys Val Lys Ile Trp Gly Glu 
865                 870                 875                 880 


Ser Phe Lys Leu Ala Glu Ile Asn Ala Asn Thr Asn Gly Ile Leu Asn 
                885                 890                 895     


Val Gln Val Pro Cys Ser Met Lys Ile Phe Gly Lys Ile Ile Glu Thr 
            900                 905                 910         


Thr Leu Lys Val Arg Asn Tyr Gly Asp Phe Val Arg Tyr Thr Lys Asp 
        915                 920                 925             


Ser Arg Leu Glu Asn Leu Phe Lys Trp Val Ser Val Lys Asn Ile Ser 
    930                 935                 940                 


Leu Ala Asp Leu Lys Thr Glu Leu Glu Asn Tyr Gln Asp Val Arg Phe 
945                 950                 955                 960 


Asp Ile Phe Ser Leu Ile His Arg Phe Glu Lys Leu Val Leu Glu Lys 
                965                 970                 975     


Phe Ala Glu Glu Val Lys Lys Glu Arg Glu Leu Asn Gln Lys Gly Gln 
            980                 985                 990         


Tyr Phe Thr Asn Phe Ser Thr Ile  Leu Asn Val Phe Tyr  Arg Tyr Phe 
        995                 1000                 1005             


Pro Asn  Phe Ala Lys Glu Arg  Ala Lys Ile Glu Ser  Leu Arg Asn 
    1010                 1015                 1020             


Asn Leu  Ser His Asn Glu Tyr  Pro Glu Ala Gln Tyr  Phe Ser Glu 
    1025                 1030                 1035             


Asn Ile  Thr Asn Leu Ser Val  Ala Val Tyr Leu Arg  Arg Ile Ala 
    1040                 1045                 1050             


Thr Glu  Leu Phe Met Arg Tyr  Asn Ser Glu Leu Ser  Lys Ile Lys 
    1055                 1060                 1065             


Leu 
    


<210>  2107
<211>  1121
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2107

Val Lys Met Glu Asp Asp Lys Lys Thr Thr Gly Ser Ile Ser Tyr Glu 
1               5                   10                  15      


Leu Lys Asp Lys His Phe Gly Ala Ala Phe Leu Asn Leu Ala Arg His 
            20                  25                  30          


Asn Val Tyr Ile Thr Ile Asn His Ile Asn Lys Leu Leu Glu Ile Arg 
        35                  40                  45              


Glu Ile Asp Asn Asp Glu Lys Val Leu Asp Ile Lys Ala Leu Trp Gln 
    50                  55                  60                  


Lys Gly Asn Lys Asp Leu Asn Gln Lys Ala Arg Leu Arg Glu Leu Met 
65                  70                  75                  80  


Thr Lys His Phe Pro Phe Leu Glu Thr Ala Ile Tyr Ser Lys Asn Lys 
                85                  90                  95      


Glu Asp Lys Glu Glu Val Lys Gln Glu Lys Gln Ala Glu Ala Gln Ser 
            100                 105                 110         


Leu Glu Ser Leu Lys Asp Cys Leu Phe Leu Phe Leu Glu Lys Leu Gln 
        115                 120                 125             


Glu Ala Arg Asn Tyr Tyr Ser His Tyr Lys Tyr Ser Glu Phe Ser Lys 
    130                 135                 140                 


Glu Pro Glu Phe Glu Glu Gly Leu Leu Glu Lys Ile Tyr Asn Ile Phe 
145                 150                 155                 160 


Asp Asp Asn Ile Gln Leu Val Ile Lys Asp Tyr Gln His Asn Lys Asp 
                165                 170                 175     


Ile Asn Pro Asp Glu Asp Phe Lys His Leu Asp Arg Thr Glu Glu Asp 
            180                 185                 190         


Phe Asn Tyr Tyr Phe Thr Arg Asn Lys Lys Gly Asn Ile Thr Ala Ser 
        195                 200                 205             


Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile 
    210                 215                 220                 


Trp Met Gln Gln Lys Leu Arg Gly Phe Lys Asp Asn Arg Glu Ser Lys 
225                 230                 235                 240 


Lys Lys Met Thr His Glu Val Phe Cys Arg Ser Arg Met Leu Leu Pro 
                245                 250                 255     


Lys Leu Arg Leu Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp 
            260                 265                 270         


Met Leu Asn Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu 
        275                 280                 285             


Gln Gly Asp Asp Arg Glu Lys Phe Lys Val Pro Phe Asp Pro Ala Asp 
    290                 295                 300                 


Glu Asp Tyr Asp Ala Glu Gln Glu Pro Phe Lys Asn Thr Leu Val Arg 
305                 310                 315                 320 


His Gln Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Tyr Asn 
                325                 330                 335     


Glu Ile Phe Thr Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His 
            340                 345                 350         


Phe Ser Ile Tyr Lys Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg His 
        355                 360                 365             


Leu Thr His Lys Leu Tyr Gly Phe Glu Arg Ile Gln Glu Phe Ala Lys 
    370                 375                 380                 


Gln Asn Arg Pro Asp Glu Trp Lys Ala Ile Val Lys Asp Phe Asp Thr 
385                 390                 395                 400 


Tyr Glu Thr Ser Asn Glu Arg Tyr Ile Ser Glu Thr Thr Pro His Tyr 
                405                 410                 415     


His Leu Glu Asn Gln Lys Ile Gly Ile Arg Phe Arg Asn Gly Asn Lys 
            420                 425                 430         


Asp Ile Trp Pro Ser Leu Lys Thr Asn Gly Glu Asn Asn Glu Lys Arg 
        435                 440                 445             


Lys Tyr Lys Leu Asp Lys Gln Tyr Gln Ala Glu Ala Phe Leu Ser Val 
    450                 455                 460                 


His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Lys Lys Glu 
465                 470                 475                 480 


Glu Pro Asn Asn Asp Lys Lys Asn Ala Ser Ile Val Glu Gly Phe Ile 
                485                 490                 495     


Lys Arg Glu Ile Arg Asp Ile Tyr Lys Leu Tyr Asp Ala Phe Ala Asn 
            500                 505                 510         


Gly Glu Ile Asn Asn Ile Asp Asp Leu Glu Lys Tyr Cys Glu Asp Lys 
        515                 520                 525             


Gly Ile Pro Lys Arg His Leu Pro Lys Gln Met Val Ala Ile Leu Tyr 
    530                 535                 540                 


Asp Glu Pro Lys Asp Met Val Lys Glu Ala Lys Arg Lys Gln Lys Glu 
545                 550                 555                 560 


Met Val Lys Asp Thr Lys Lys Leu Leu Ala Thr Leu Glu Lys Gln Thr 
                565                 570                 575     


Gln Gly Glu Ile Glu Asp Gly Gly Arg Asn Ile Arg Leu Leu Lys Ser 
            580                 585                 590         


Gly Glu Ile Ala Arg Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro 
        595                 600                 605             


Val Gln Lys Asp Asn Glu Gly Asn Pro Leu Asn Asn Ser Lys Ala Asn 
    610                 615                 620                 


Ser Thr Glu Tyr Gln Met Leu Gln Arg Ser Leu Ala Leu Tyr Asn Lys 
625                 630                 635                 640 


Glu Glu Lys Pro Thr Arg Tyr Phe Arg Gln Val Asn Leu Ile Asn Ser 
                645                 650                 655     


Ser Asn Pro His Pro Phe Leu Lys Trp Thr Lys Trp Glu Glu Cys Asn 
            660                 665                 670         


Asn Ile Leu Ser Phe Tyr Arg Ser Tyr Leu Thr Lys Lys Ile Glu Phe 
        675                 680                 685             


Leu Asn Lys Leu Lys Pro Glu Asp Trp Glu Lys Asn Gln Tyr Phe Leu 
    690                 695                 700                 


Lys Leu Lys Glu Pro Lys Thr Asn Arg Glu Thr Leu Val Gln Gly Trp 
705                 710                 715                 720 


Lys Asn Gly Phe Asn Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg 
                725                 730                 735     


Glu Trp Phe Lys Arg His Gln Asn Asp Ser Lys Glu Tyr Glu Lys Val 
            740                 745                 750         


Glu Ala Leu Lys Arg Val Gly Leu Val Thr Lys Val Ile Pro Leu Phe 
        755                 760                 765             


Phe Lys Glu Glu Tyr Phe Lys Glu Asp Ala Gln Lys Glu Ile Asn Asn 
    770                 775                 780                 


Cys Val Gln Pro Phe Tyr Ser Leu Pro Tyr Asn Val Gly Asn Ile His 
785                 790                 795                 800 


Lys Pro Asp Glu Glu Asp Phe Leu His Arg Glu Glu Arg Ile Glu Leu 
                805                 810                 815     


Trp Gly Lys Lys Lys Asp Lys Phe Lys Gly Tyr Lys Ala Lys Val Lys 
            820                 825                 830         


Ser Lys Lys Leu Thr Asp Lys Glu Lys Glu Glu Tyr Arg Ser Tyr Leu 
        835                 840                 845             


Glu Phe Gln Ser Trp Asn Lys Phe Glu Arg Glu Leu Arg Leu Val Arg 
    850                 855                 860                 


Asn Gln Asp Ile Val Thr Trp Leu Leu Cys Thr Glu Leu Ile Asp Lys 
865                 870                 875                 880 


Leu Lys Val Glu Gly Leu Asn Val Glu Glu Leu Lys Lys Leu Arg Leu 
                885                 890                 895     


Lys Asp Ile Asp Thr Asp Thr Ala Lys Gln Glu Lys Asn Asn Ile Leu 
            900                 905                 910         


Asn Arg Ile Met Pro Met Gln Leu Pro Val Thr Val Tyr Glu Ile Asp 
        915                 920                 925             


Asp Ser His Asn Ile Val Lys Asp Arg Pro Leu His Thr Val Tyr Ile 
    930                 935                 940                 


Glu Glu Thr Lys Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu 
945                 950                 955                 960 


Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Val Asp Thr Ser 
                965                 970                 975     


Ser Glu Ala Glu Leu Lys Ser Asn Pro Ile Ser Lys Ser Val Val Glu 
            980                 985                 990         


Tyr Glu Leu Gly Glu Tyr Gln Asn  Ala Arg Ile Glu Thr  Ile Lys Asp 
        995                 1000                 1005             


Met Leu  Leu Leu Glu Lys Thr  Leu Ile Lys Lys Tyr  Lys Thr Leu 
    1010                 1015                 1020             


Pro Thr  Asn Lys Phe Ser Ala  Met Leu Asn Gly Trp  Leu Glu Gly 
    1025                 1030                 1035             


Lys Asp  Glu Ser Asp Lys Ala  Arg Phe Gln Asn Asp  Val Lys Leu 
    1040                 1045                 1050             


Leu Val  Ala Val Arg Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met 
    1055                 1060                 1065             


Arg Asn  Arg Ile Ala Phe Ala  Asn Ile Asn Pro Phe  Ser Leu Ser 
    1070                 1075                 1080             


Ser Ala  Asp Ile Ser Glu Glu  Lys Gly Leu Asn Ile  Ala Asn Gln 
    1085                 1090                 1095             


Leu Lys  Asp Lys Thr His Lys  Thr Ile Lys Lys Ile  Ile Glu Ile 
    1100                 1105                 1110             


Glu Lys  Pro Ile Glu Thr Lys  Glu 
    1115                 1120     


<210>  2108
<211>  1375
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2108

Met Glu Ser Ser Asn Lys Arg Lys Lys Asp Lys Ser Gln Asn Ala Leu 
1               5                   10                  15      


Lys Gly Lys Asn Val Tyr Ile Asp Glu Phe Val Val Thr Met Lys Asn 
            20                  25                  30          


Phe Ser Leu Pro Lys Tyr His Lys His Ile Leu Ala Ala Tyr Tyr Asn 
        35                  40                  45              


Leu Ala Arg Arg Asn Leu Tyr Met Thr Ile Ala Asn Val Phe Val Tyr 
    50                  55                  60                  


Ala Gly Gly Gln Phe Pro Phe Thr Glu Asp Asp Met Val Met Pro Leu 
65                  70                  75                  80  


Lys Val Leu His Asp Leu Ile Ser Lys His Lys Cys Tyr Gly Asp Ile 
                85                  90                  95      


Lys Lys Ala Ala Glu Tyr Glu Lys Gln Met Ser Phe Lys Lys Ile Asp 
            100                 105                 110         


Gln Lys Lys Leu His Ser Arg Leu Tyr His Ser Leu Pro Met Leu Ala 
        115                 120                 125             


Pro Ala Thr Asp Asp Ile Lys Glu Met Gln Leu Lys Ser Ile Leu Ser 
    130                 135                 140                 


Glu Thr Ser Ala Ser Leu Val Ser Thr Leu Glu Asp Cys Leu Lys Ala 
145                 150                 155                 160 


Leu Ile His Tyr Thr Ala Thr Ile Thr Asp Cys Arg Asn Ile Tyr Thr 
                165                 170                 175     


His Tyr Arg Ala Tyr Lys Ser Pro Glu Asn Gln Glu Ile Ala Tyr Asp 
            180                 185                 190         


Asn Gln Lys Glu Val Ser Phe Phe Leu Asp Ala Val Met Lys Ala Gly 
        195                 200                 205             


Arg Arg Ile Cys Lys Arg Leu Asp Asn Leu Ser Gln Glu Asp Met Asp 
    210                 215                 220                 


Phe Ile Glu Gln Gly Lys His Tyr Glu Gln Val Ser Val Ile Asp Glu 
225                 230                 235                 240 


Lys Thr Gly Leu Pro Lys Lys Asp Lys Lys Gly Arg Ile Ile Lys Val 
                245                 250                 255     


Pro Ser Glu Arg Lys Asn Phe Tyr Phe Arg Ile Lys Gly Val Arg Asp 
            260                 265                 270         


Val Val Asp Ala Lys Gly Lys Pro Ile Asp Gly Asn Ser Cys His Ala 
        275                 280                 285             


Leu Ser Asp Phe Gly Leu Ile Phe Leu Ala Val Leu Phe Leu Lys Lys 
    290                 295                 300                 


Thr Asp Ala Glu Ala Leu Met Ser Glu Val Gln Leu Met Glu Lys Ser 
305                 310                 315                 320 


Pro Phe Ser Ser Lys Glu Asn Glu Leu Val Lys Ser Phe Met Ser Val 
                325                 330                 335     


Tyr Arg Ile His Leu Pro Lys Gly Lys Arg Leu Asp Ile Asn Asp Asp 
            340                 345                 350         


Ala Thr Gln Leu Gly Met Asp Met Leu Asn Glu Leu Arg Lys Cys Pro 
        355                 360                 365             


Lys Glu Leu Tyr Glu Leu Leu Asp Leu Lys Gly Lys Lys Thr Phe Glu 
    370                 375                 380                 


Asp Asp Val Thr Val Leu Thr Gly Asp Ile Asp Pro Val Ser His Asn 
385                 390                 395                 400 


Pro Ile Ser Arg Thr Thr Gly Glu Lys Ala Val Arg Lys Arg Tyr Val 
                405                 410                 415     


Asp Arg Phe Pro Tyr Leu Ala Leu Arg Tyr Ile Asp Lys Lys Asn Leu 
            420                 425                 430         


Leu Glu Asp Ile Arg Phe Gln Leu His Leu Gly Ser Tyr Arg Phe Ser 
        435                 440                 445             


Phe Tyr Lys Lys Thr Thr Ile Asp Gly Glu Glu Lys Leu Arg Ile Leu 
    450                 455                 460                 


Gln Arg Gly Ile Asn Gly Tyr Gly Lys Leu Val Glu Val Glu Gly Glu 
465                 470                 475                 480 


Arg Leu Ile Leu Trp Glu Glu His Phe Gln Lys Phe Glu Ile Lys Asp 
                485                 490                 495     


Pro Asn Glu Thr Glu Lys Ser Glu Ile Ala Ile Asp Glu Asp Gly Asn 
            500                 505                 510         


Ile Ile Gln Leu Ile Gln Pro Thr Glu Ser Val Val Asn Asp Thr Pro 
        515                 520                 525             


Tyr Val Thr Asp His Arg Ala Ser Tyr Asn Phe Thr Val Asn Arg Ile 
    530                 535                 540                 


Gly Leu Tyr Trp Gln Glu Glu Gly Ile Val Gly Val Ala Gly Glu Lys 
545                 550                 555                 560 


Phe Leu Pro Ala Leu Thr Tyr Lys Arg His Ala Glu Ser Leu Gln Asp 
                565                 570                 575     


Asp Asp Arg Arg Lys Arg Ala Thr Val Ser Gln Pro Ala Pro Leu Ala 
            580                 585                 590         


Phe Leu Ser Thr Arg Glu Leu Pro Ala Leu Leu Phe Tyr His Tyr Leu 
        595                 600                 605             


Trp Asn Thr His Arg Leu Gly Asn Asp Pro Val Ala Ser Ile Ile Lys 
    610                 615                 620                 


Asn Glu Tyr Arg Lys Met Arg Gln Met Phe Leu Gly Ile Ala Asp Gly 
625                 630                 635                 640 


Ser Ile Thr Ser Lys Asp Gly Ile Glu Asn Leu Gly Ile Lys Trp Ala 
                645                 650                 655     


Asn Val Pro Gln Lys Leu Arg Asp Tyr Leu Thr His Lys Asn Val Asn 
            660                 665                 670         


Pro Ser Asp Arg Leu Val Gln Val Phe Phe Gly Lys Gly Lys Asp Lys 
        675                 680                 685             


Gly His Leu Gln Glu Arg Ile Asp Trp Ile Glu Arg Lys Lys Ser Lys 
    690                 695                 700                 


Phe Glu Glu Leu Gln Lys Arg Ile Lys Ala Gly Asp Asn Lys Arg Gly 
705                 710                 715                 720 


Lys Lys Lys Phe Asp Thr Ile Arg Pro Asn Glu Ile Ala Arg Asn Leu 
                725                 730                 735     


Ala Thr Trp Ile Met Asp Trp Ile Pro Gln Asp Ser Lys Cys Ala Ala 
            740                 745                 750         


Val Met Thr Thr Pro Asn Phe Glu Ala Leu Val Asp Met Leu Ala Lys 
        755                 760                 765             


Tyr Gly Ile His Glu Asp Tyr Asp Glu Ser Lys Leu Arg Thr Thr Leu 
    770                 775                 780                 


Thr Asn Gly Tyr Val Met Gln Cys His Pro Phe Met Thr Asp Val Met 
785                 790                 795                 800 


Asn Gln His Pro Lys Asp Ile Glu Arg Leu Tyr Val Thr Tyr Met Asp 
                805                 810                 815     


Lys Glu Ile Phe Lys Leu Lys Ser Ile Leu Asn Gln Ser His Ser Arg 
            820                 825                 830         


Lys Ala Leu Glu Ala Ile Pro Phe Ala His Thr Asp Arg Leu Arg Trp 
        835                 840                 845             


Thr Ser Arg Asn Asp Ala Tyr Tyr Lys Ala Leu Ala Lys Arg Tyr Leu 
    850                 855                 860                 


Asn Ile Asp Asp Lys Ser Arg Ala Val Leu Phe Leu Pro Asp Gly Leu 
865                 870                 875                 880 


Phe Thr Glu His Ile Leu Arg Ile Leu Gln Asn Pro Asp Asp Ala Lys 
                885                 890                 895     


Phe Ser Gly Ile Glu Ala Phe Lys Thr Lys Glu Gly Asn Ala Lys Glu 
            900                 905                 910         


Glu Asn Glu Gln His Asn Val Ser Tyr Leu Ile Ser Thr Phe Leu Glu 
        915                 920                 925             


Ser Val Leu Gly Asp Arg Ser Gln Ser Tyr Tyr Tyr Asp Leu Gly Arg 
    930                 935                 940                 


Ser Tyr Asp Phe Phe Lys Glu Met Lys Arg Glu Lys Lys Asp Val Lys 
945                 950                 955                 960 


Asn Pro Arg Ser Ala Leu Lys Asn Gln Tyr Leu Lys Pro Leu Gln Ile 
                965                 970                 975     


Ala Glu Ala Leu Arg Gly Arg Ala Glu Leu Lys Lys Lys Ile Ser Ile 
            980                 985                 990         


Phe Val Asn Asn Leu Tyr Asn Ser  Lys Glu Ile Gln Ser  Gln Leu Gln 
        995                 1000                 1005             


Lys Glu  Glu Glu Asn Leu Gln  Ser Arg Leu Asp Trp  Glu Arg Asn 
    1010                 1015                 1020             


Pro Arg  Lys Arg Glu Lys Ile  Asn Met Glu Leu Glu  Ala Phe Leu 
    1025                 1030                 1035             


Ser Asn  Lys Arg Thr Trp Lys  Leu Arg Met Asn Asp  Lys Leu Leu 
    1040                 1045                 1050             


Arg Leu  Ala His Glu Cys Ala  Lys Asn Glu Arg Thr  Ile Arg Arg 
    1055                 1060                 1065             


Tyr Arg  Ile Gln Asp Ile Leu  Ile Phe Leu Met Ala  Lys Asp Leu 
    1070                 1075                 1080             


Leu Gly  Asn Ser Phe Lys Glu  Arg Thr Gln Gln Lys  Pro Phe Met 
    1085                 1090                 1095             


Leu Gln  Asn Val Ser Ser Pro  Ala Phe Leu Ser Gln  Thr Val Glu 
    1100                 1105                 1110             


Phe Thr  Tyr Lys Thr Lys Ser  Ser Cys Lys Tyr Lys  Lys Gly Asp 
    1115                 1120                 1125             


Asn Thr  Tyr Thr Ile Thr Met  Pro Ile Glu Ile Arg  Gln Asp Asn 
    1130                 1135                 1140             


Leu Ala  Ile Lys Asn Tyr Asn  Leu Ala Phe Arg Tyr  Leu Lys Asp 
    1145                 1150                 1155             


Asp Arg  Leu Gly Ser Phe Leu  Ser Gln Leu Val Arg  Val Val Ala 
    1160                 1165                 1170             


Glu Asn  Thr Asp Gly Glu Glu  Thr Lys Ala Asn Met  Ser Thr Ile 
    1175                 1180                 1185             


Val Val  Asp Tyr Asn Lys Leu  Ser Gly Glu Phe Asp  Ser Tyr Asn 
    1190                 1195                 1200             


Lys Leu  Arg Ser Gln Ile Phe  Asp Val Ile His Gln  Ile Glu Ser 
    1205                 1210                 1215             


Leu Ile  Val Asp Pro Asn Lys  Ala Ile Tyr Asn Asn  Pro Val His 
    1220                 1225                 1230             


Lys Asn  Phe Tyr Val His Asp  Ser Leu Arg Ala Lys  Asn Gly Glu 
    1235                 1240                 1245             


Glu Arg  Thr Asp Glu Asn Ala  Val Arg Asn Ser Phe  Ser Ser Leu 
    1250                 1255                 1260             


Leu Lys  Thr Val Tyr Lys Ile  Leu Pro Asp Asp Glu  Ile Lys Thr 
    1265                 1270                 1275             


Ile Gln  Gln Glu Ala Glu Lys  Ala Glu Ala Leu Arg  Val Ser Leu 
    1280                 1285                 1290             


Ile Tyr  Lys Val Met Val Ala  Ile Arg Asn Ala Phe  Ser His Asn 
    1295                 1300                 1305             


His Phe  Asp Ile Asp Leu Leu  Gln Ile Ala Ala Pro  Gln Thr Leu 
    1310                 1315                 1320             


Arg Ile  Ile Ile Asp Ser Leu  Asn Leu Gln Ala Glu  Asp Gly Met 
    1325                 1330                 1335             


Gln Lys  Lys Gly Lys Asp Glu  Lys Ile Glu His Ile  Ser Lys Leu 
    1340                 1345                 1350             


Ile Leu  Ser Lys Leu Gln Thr  Leu Arg Asp Thr Leu  Asn Lys Asp 
    1355                 1360                 1365             


Ile Tyr  Asn Lys Ser Asn Gln  
    1370                 1375 


<210>  2109
<211>  1519
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2109

Met Ala Thr Phe Arg Phe Gln Asn Lys Tyr Val Cys Gly Ala Tyr Tyr 
1               5                   10                  15      


Asn Met Ala Gln Asn Asn Phe Arg Leu Ala Ile Leu His Val Leu Ser 
            20                  25                  30          


Arg Ile Gly Ile Asn Arg Lys Asp Glu Glu Arg Ala Ile Pro Glu Leu 
        35                  40                  45              


Leu Asp Thr Ile Tyr Gly Phe Leu Thr Gly Asp Thr Glu His Phe Asn 
    50                  55                  60                  


Asp Thr Gln Ile Leu Gln Lys Lys Val Leu Thr Leu Arg Tyr Asp Gln 
65                  70                  75                  80  


Gln Val Lys Leu Arg Glu Leu Leu Phe Arg Gln Phe Pro Ile Leu Lys 
                85                  90                  95      


Pro Ile Ile Ala Ser Glu Thr His Lys Ser Leu Gln Glu Gln Lys Glu 
            100                 105                 110         


Lys Leu Ser Glu Met Glu Glu Tyr Ile His Glu Phe Glu Lys Gln Leu 
        115                 120                 125             


Lys Arg Leu Tyr Arg Ser Lys Lys Gly Lys Ala Ser Gln Glu Gln Lys 
    130                 135                 140                 


Glu Ile Asn Glu Gln Ile Lys Tyr Leu Lys Thr Lys Lys Ser Lys Tyr 
145                 150                 155                 160 


Leu Asp Glu Tyr Asp Thr Leu Leu Phe Ser Lys Ser His Asp Ala Asp 
                165                 170                 175     


Leu Gln Leu Cys Leu Lys Ile Leu Lys Thr Met Ala Trp Cys Leu Tyr 
            180                 185                 190         


Asp Leu Arg Asp Phe Tyr Thr His Tyr Asp Pro Tyr Asn Thr Pro Glu 
        195                 200                 205             


Ser Leu Lys Val Lys Tyr Leu Arg Gln Val Thr Val Ala Asn Trp Leu 
    210                 215                 220                 


Ser Gln Val Phe Ala Ala Ser Arg Thr Ile Asp Lys Glu Arg Asn Ser 
225                 230                 235                 240 


Ile Thr Thr Glu Glu Met Asn Phe Leu Asn Glu Ala Lys Lys Gln Gly 
                245                 250                 255     


Asn Asp Lys Lys Trp Arg Glu Asp Pro Asp Tyr Tyr Phe Ala Ile Lys 
            260                 265                 270         


Gly Gln Asn Leu Leu Ser Ser Ser Phe Lys Asp Ser Asp Ser Pro Ala 
        275                 280                 285             


Asn Asn Asp Tyr Leu Asp Glu Leu Tyr Gln Lys Tyr Arg Lys Lys Arg 
    290                 295                 300                 


Leu Ala Trp Met Lys Glu Gln Arg Asp Glu Ala Leu Glu Arg Asp Asp 
305                 310                 315                 320 


Glu Glu Glu Tyr Gly Phe Trp Val Val Glu Met Glu Lys Leu Asp Asn 
                325                 330                 335     


Pro Glu Arg Ile Ala Lys Ile Lys Ser Lys Ile Cys Pro Leu Ala Leu 
            340                 345                 350         


Ser Asp Phe Gly Val Leu Tyr Phe Cys Ala Thr Phe Leu Pro Arg Asn 
        355                 360                 365             


Tyr Thr Leu Leu Met Ala Asp His Ala Glu Val Met Lys Asn Ser Pro 
    370                 375                 380                 


Tyr Ser Met Thr Ala Glu Glu Leu Glu Ala Arg Arg Asn Ala Cys Lys 
385                 390                 395                 400 


Thr Asp Glu Glu Arg Glu Lys Ile Asp Pro Thr Asp Thr Pro Arg Asn 
                405                 410                 415     


Asn Ile Leu Arg Glu Met Leu Cys Ile Tyr Arg Val Arg Leu Pro Lys 
            420                 425                 430         


Gly Lys Arg Leu Asp Lys Lys Asp Thr Lys Gly Leu Leu Thr Leu Asp 
        435                 440                 445             


Ile Leu Asn Glu Leu Arg Lys Cys Pro Lys Glu Val Tyr Glu Gln Leu 
    450                 455                 460                 


Ser Lys Glu Gly Lys Asp Phe Phe Ile Ser Arg Val Ser Ser Ala Ser 
465                 470                 475                 480 


His Asn Ala Pro Asp Ile Val Lys Arg Ile Arg Phe Gly Asp Arg Phe 
                485                 490                 495     


Pro Tyr Leu Ala Leu Arg Ala Ile Asp Glu Ser Asp Val Phe Lys Arg 
            500                 505                 510         


Ile Arg Phe Gln Val Arg Leu Gly Ser Tyr Arg Phe Tyr Phe Tyr Asn 
        515                 520                 525             


Lys Thr Cys Ile Asp Gly Ser Thr Gln Leu Arg Arg Trp Gln Lys Glu 
    530                 535                 540                 


Ile Asn Gly Phe Gly Arg Leu Gln Asp Met Glu Ala Leu Arg Lys Ser 
545                 550                 555                 560 


Leu Trp Lys Asp Leu Leu Gln Lys Lys Glu Tyr Asp Ser Val Gln Leu 
                565                 570                 575     


Glu Asp Lys Ser Ser Tyr Leu Asp Leu Gln Gln Phe Lys Ala Asp Ala 
            580                 585                 590         


Pro Asp Ser Val Pro Tyr Ile Thr Asp Ser Gln Ala Gln Tyr Asn Ile 
        595                 600                 605             


His Asn Asn Arg Ile Gly Leu Ile Trp Asn Gly Asp Glu Cys Arg Leu 
    610                 615                 620                 


Leu Arg Asn Ile Lys Asp Ala Asp Val Leu Arg Glu Tyr Val Tyr Leu 
625                 630                 635                 640 


Pro Asp Leu Lys Asp Asn Asp Gly Asn Pro Lys Lys Ser Gly Lys Asp 
                645                 650                 655     


Ile Glu Gln Pro Ser Pro Leu Cys Ser Leu Ser Thr Tyr Glu Leu Pro 
            660                 665                 670         


Ala Leu Leu Phe Tyr His Phe Leu Tyr Asn Thr Pro Glu Ala Gln Val 
        675                 680                 685             


His Lys Glu Arg Leu Glu Lys Pro Glu Gln Val Ile Ile Lys Lys Tyr 
    690                 695                 700                 


Gly Ala Leu Arg Ala Phe Phe Leu Glu Leu Arg Ser His Pro Glu Gln 
705                 710                 715                 720 


Ile Val Lys Thr Asp Leu Gln Ala Thr Leu Thr Arg Phe Gly Leu Lys 
                725                 730                 735     


Cys Ser Glu Ile Pro Gln Arg Ile Ile Asp Cys Ile Gln Gly Cys Gln 
            740                 745                 750         


Gln Lys Gln Lys Glu Thr Glu Ser Ser Val Thr Tyr Leu Pro Asp Leu 
        755                 760                 765             


Leu Gln Leu Pro Met Glu Asp Ile Arg Gln Lys Val Gln Glu Lys Gly 
    770                 775                 780                 


Met Glu Arg Tyr Lys Asp Leu Pro Ala Lys Phe Arg Lys Gln Ile Ser 
785                 790                 795                 800 


His Glu Gln Ile Val Thr Ser Gly Leu Glu Thr Leu Leu Lys Pro Leu 
                805                 810                 815     


Gly Ile Ser Val Glu Ser Leu Pro Ala Lys Val Met Glu Ala Leu Leu 
            820                 825                 830         


Ser Thr Gln Ile Gln Glu Asp Val Ala Pro Ala Glu Asp Thr Ala Thr 
        835                 840                 845             


Glu Lys Pro Phe Asn Ile Met Phe Val Arg Ser Val Val Tyr Lys Leu 
    850                 855                 860                 


His Glu Arg Leu Gln Asp Val Ser Lys Arg His Gln Ser Phe Val Glu 
865                 870                 875                 880 


Ser Ile His His Val Gly Ser Lys Asp Asn Lys Phe Ala Lys His Gly 
                885                 890                 895     


Tyr Met Asp Val Arg His Gly Lys Leu Ala Glu Tyr Leu Ala Gly Ser 
            900                 905                 910         


Phe Leu Lys Trp Gln Pro Thr Ile Ser Asn Gly Ser Asp Lys Leu Thr 
        915                 920                 925             


Gly Leu Asn Tyr Asn Val Leu Lys Ser Phe Leu Ser Thr Tyr Gly Ile 
    930                 935                 940                 


Ala Thr Asp Ile Asp Asp Leu Thr Ala Val Leu His Glu Ala Lys Leu 
945                 950                 955                 960 


Ile His Leu Gly Lys Glu Glu Thr Pro Ile Pro His Pro Phe Leu Gln 
                965                 970                 975     


Lys Val Ile Asp Lys Glu Pro Gly Asn Leu Glu Lys Leu Phe His Leu 
            980                 985                 990         


Tyr Ile Ile Gln Glu Lys Glu Tyr  Leu Ser Asp Leu Leu  Ile Asp Tyr 
        995                 1000                 1005             


Leu Leu  Gln Ile Ser Thr Ala  Ile Gly Thr Glu Gly  Gln Asp Ala 
    1010                 1015                 1020             


Asp Met  Leu Glu Glu Ala Tyr  Thr Cys Asn Gly Glu  Lys Leu Ile 
    1025                 1030                 1035             


Ser Asp  Met Leu Glu Glu Tyr  Lys Ala Lys Ser Thr  Ala Asp Ser 
    1040                 1045                 1050             


Arg Gln  Ser Val Tyr Gln Leu  Glu His Pro Ala Phe  Thr His Pro 
    1055                 1060                 1065             


Lys Arg  Glu Arg Trp Lys Gln  Gly Thr Asn Ile Ala  Thr Leu Ala 
    1070                 1075                 1080             


Gln Leu  Ala Lys Ser Tyr Thr  Asn Pro Leu Leu Leu  Pro Asp Gly 
    1085                 1090                 1095             


Leu Phe  Thr Glu Ala Ile Arg  His Leu Met Glu Ile  Val Tyr Ser 
    1100                 1105                 1110             


Asp Asn  Gln Lys Leu Gln Asp  Glu Leu Ser Arg Gln  Asn Ser Lys 
    1115                 1120                 1125             


Gly Glu  Ala Ala Ser His Ser  Val Ala Phe Ile Ile  Asp Val Tyr 
    1130                 1135                 1140             


Ser Arg  Ile Val Leu Asn Asp  His Ala Gln Ser Tyr  Tyr Cys Ser 
    1145                 1150                 1155             


Asp Leu  Val Gln Pro Glu Cys  Thr Asn Phe Ala Arg  Ser Tyr Arg 
    1160                 1165                 1170             


Leu Phe  Asp Lys Leu Asn Asn  Gln Lys Asp Pro Phe  Lys Ala Phe 
    1175                 1180                 1185             


Ile Arg  Val Pro Met Asp Thr  Ile Gly Ile Met Gln  Lys Leu Lys 
    1190                 1195                 1200             


Thr Gly  Lys Glu Gln Phe Glu  Ala Glu Val Glu Thr  Tyr Ile Ile 
    1205                 1210                 1215             


Asp Thr  Glu Arg Arg Glu Lys  Ala Glu Ala Glu Gln  Lys Val Arg 
    1220                 1225                 1230             


Asn Lys  Ser Val Arg Glu Asn  Trp Lys Leu Asp Arg  Tyr Glu Gln 
    1235                 1240                 1245             


Glu Arg  Glu Arg Ala Ile Asp  Asn Ala Ser Trp Pro  Asp Ser Lys 
    1250                 1255                 1260             


Lys Gln  Glu Glu Arg Asp Lys  Met Glu Arg Met Lys  Arg Phe Val 
    1265                 1270                 1275             


Gln Lys  Asn Glu Arg Ala Ile  Arg Arg Tyr Arg Ile  Gln Asp Ile 
    1280                 1285                 1290             


Thr Leu  Phe Leu Met Ala Arg  Asn Met Leu Ser Glu  Val Phe Ser 
    1295                 1300                 1305             


Gly Asp  Asp Gly Gln Ser Phe  Asp Glu Gln Ser Arg  Gln Asn Leu 
    1310                 1315                 1320             


Lys Leu  Glu Asn Val Cys Asn  Glu Asp Phe Leu Ser  Gln Thr Ile 
    1325                 1330                 1335             


Asp Tyr  Glu Tyr Ala Tyr Gln  Leu Gly Asp Arg Thr  Val Thr Ile 
    1340                 1345                 1350             


Arg Gln  Ala Gly Met Ser Leu  Lys Asn Tyr Gly Gln  Phe Tyr Arg 
    1355                 1360                 1365             


Phe Leu  Gly Asp Val Arg Leu  Asp Thr Leu Leu Met  Leu Leu Ala 
    1370                 1375                 1380             


Asn Val  Lys Ser Val Thr Leu  Thr Asp Val Ala Ser  Glu Phe Ala 
    1385                 1390                 1395             


Lys Tyr  Asp Gln Glu Arg Pro  Leu Ala Phe Lys Lys  Leu Gln Leu 
    1400                 1405                 1410             


Leu Glu  Gln Leu Ala Ile Glu  Thr Asp Gln Thr Gly  Thr Leu Tyr 
    1415                 1420                 1425             


Asn Pro  Glu Ala Asp Gly Phe  Ser Phe Ile Asn Pro  Lys Gly Gln 
    1430                 1435                 1440             


Lys Glu  Pro Lys Arg Asn Asn  Phe Ala Lys Leu Leu  Asp Leu Leu 
    1445                 1450                 1455             


Lys Asp  Leu Gly Ser Asp Lys  Asn Lys Leu Leu Thr  Asp Ile Arg 
    1460                 1465                 1470             


Asn Ala  Leu Gly His Asn Lys  Tyr Ile Thr Asp Ser  Ser Ala Met 
    1475                 1480                 1485             


Thr Leu  Asn Glu Gln Leu Glu  Ile Thr Gln Val Ala  Val Lys Met 
    1490                 1495                 1500             


Ser Glu  Gln Ile Ser Leu Leu  Gln Gln Gly Ile Gln  Glu Asn Ile 
    1505                 1510                 1515             


Lys 
    


<210>  2110
<211>  1093
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2110

Leu Ala Arg His Asn Val Tyr Ile Thr Ile Asn His Ile Asn Lys Leu 
1               5                   10                  15      


Leu Glu Ile Arg Glu Ile Asp Asn Asp Glu Lys Ile Leu Asp Ile Lys 
            20                  25                  30          


Thr Leu Trp Glu Lys Val Asn Gly Asp Leu Asn Lys Thr Glu Arg Leu 
        35                  40                  45              


Arg Glu Leu Met Thr Lys His Phe Pro Phe Leu Glu Thr Ala Ile Tyr 
    50                  55                  60                  


Ser Lys Asn Lys Glu Asp Lys Glu Glu Val Lys Gln Glu Lys Gln Ala 
65                  70                  75                  80  


Thr Ala Gln Ser Phe Lys Ser Leu Glu His Cys Leu Phe Leu Phe Leu 
                85                  90                  95      


Lys Lys Leu Gln Glu Ala Arg Asn Tyr Tyr Ser His Tyr Lys Tyr Ser 
            100                 105                 110         


Glu Ser Thr Lys Glu Pro Met Leu Glu Lys Glu Leu Leu Lys Lys Met 
        115                 120                 125             


Tyr Asn Ile Phe Asp Asp Asn Ile Gln Leu Val Ile Lys Asp Tyr Gln 
    130                 135                 140                 


His Asn Lys Asp Ile Asn Pro Asp Glu Asp Phe Lys His Leu Asn Arg 
145                 150                 155                 160 


Thr Glu Lys Glu Phe Asn Tyr Tyr Phe Thr Thr Asn Lys Lys Gly Asn 
                165                 170                 175     


Ile Thr Ala Ser Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys 
            180                 185                 190         


Lys Asp Ala Ile Trp Met Gln Gln Lys Leu Arg Gly Phe Lys Asp Asn 
        195                 200                 205             


Arg Glu Ser Lys Lys Lys Met Thr His Glu Val Phe Cys Arg Ser Arg 
    210                 215                 220                 


Met Leu Leu Pro Lys Leu Arg Leu Glu Ser Thr Gln Thr Gln Asp Trp 
225                 230                 235                 240 


Ile Leu Leu Asp Met Leu Asn Glu Leu Ile Arg Cys Pro Lys Ser Leu 
                245                 250                 255     


Tyr Glu Arg Leu Gln Gly Val Asp Arg Glu Lys Phe Arg Val Pro Ile 
            260                 265                 270         


Glu Ile Ala Asp Glu Asp Tyr Asp Ala Glu Gln Glu Pro Phe Lys Asn 
        275                 280                 285             


Thr Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr 
    290                 295                 300                 


Phe Asp Tyr Asn Glu Ile Phe Thr Asn Leu Arg Phe Gln Ile Asp Leu 
305                 310                 315                 320 


Gly Thr Tyr His Phe Ser Ile Tyr Lys Lys Leu Ile Gly Gly Gln Lys 
                325                 330                 335     


Glu Asp Arg His Leu Thr His Lys Leu Tyr Gly Phe Glu Arg Ile Gln 
            340                 345                 350         


Glu Phe Asn Lys Gln Asn Arg Pro Asp Glu Trp Lys Ala Leu Val Lys 
        355                 360                 365             


Asp Leu Asp Thr Tyr Glu Thr Ser Glu Glu Pro Tyr Ile Ser Glu Thr 
    370                 375                 380                 


Thr Pro His Tyr His Leu Glu Asn Gln Lys Ile Gly Ile Arg Phe Arg 
385                 390                 395                 400 


Asn Gly Asn Asn Asp Ile Trp Pro Ser Leu Glu Thr Asn Gly Glu Asn 
                405                 410                 415     


Asn Glu Lys Ser Lys Tyr Lys Leu Asp Lys Gln Tyr Gln Ala Glu Ala 
            420                 425                 430         


Phe Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu 
        435                 440                 445             


Leu Lys Lys Glu Lys Pro Asn Asn Asp Glu Ile Asn Ala Ser Ile Val 
    450                 455                 460                 


Glu Gly Phe Ile Lys Arg Glu Ile Arg Tyr Ile Tyr Lys Leu Tyr Asp 
465                 470                 475                 480 


Ala Phe Ala Asn Gly Glu Ile Asn Ser Ile Gly Asp Leu Glu Lys Tyr 
                485                 490                 495     


Cys Glu Asp Lys Gly Ile Pro Lys Arg His Leu Pro Lys Gln Met Val 
            500                 505                 510         


Ala Ile Leu Tyr Asp Glu His Lys Asp Met Val Lys Glu Ala Lys Arg 
        515                 520                 525             


Lys Gln Arg Lys Met Val Lys Glu Thr Glu Lys Leu Leu Ala Ala Leu 
    530                 535                 540                 


Glu Lys Gln Thr Gln Glu Glu Ile Glu Asp Gly Gly Arg Asn Ile Arg 
545                 550                 555                 560 


Leu Leu Lys Ser Gly Glu Ile Ala Arg Trp Leu Val Asn Asp Met Met 
                565                 570                 575     


Arg Phe Gln Pro Val Gln Lys Asp Asn Glu Gly Asn Pro Leu Asn Asn 
            580                 585                 590         


Ser Lys Ala Asn Ser Thr Glu Tyr Gln Met Leu Gln Arg Ser Leu Ala 
        595                 600                 605             


Leu Tyr Asn Lys Glu Glu Lys Pro Thr Arg Tyr Phe Lys Gln Val Asn 
    610                 615                 620                 


Leu Ile Glu Ser Gly Asn Pro His Pro Phe Leu Asn Asn Thr Gly Trp 
625                 630                 635                 640 


Lys Glu Cys Asn Asn Ile Leu Ser Phe Tyr Arg Ser Tyr Leu Thr Lys 
                645                 650                 655     


Lys Ile Glu Phe Leu Asn Glu Leu Lys Pro Glu Asp Trp Glu Lys Asn 
            660                 665                 670         


Gln Tyr Phe Leu Lys Leu Lys Glu Pro Lys Thr Asn Arg Lys Thr Leu 
        675                 680                 685             


Val Gln Gly Trp Lys Asn Gly Phe Asn Leu Pro Arg Gly Ile Phe Thr 
    690                 695                 700                 


Glu Pro Ile Arg Glu Trp Phe Lys Arg His Gln Asn Val Ser Glu Glu 
705                 710                 715                 720 


Tyr Asn Lys Val Glu Ala Leu Asp Arg Val Gly Leu Val Thr Lys Val 
                725                 730                 735     


Ile Pro Leu Phe Phe Lys Glu Glu Tyr Phe Lys Asp Asp Ala Gln Lys 
            740                 745                 750         


Glu Ile Asn Asn Cys Val Gln Pro Phe Tyr Ser Leu Pro Tyr Asn Val 
        755                 760                 765             


Gly Asn Ile His Lys Pro Asp Glu Lys Asp Phe Leu His Arg Glu Glu 
    770                 775                 780                 


Arg Ile Glu Leu Trp Gly Lys Lys Lys Asp Lys Phe Lys Gly Tyr Lys 
785                 790                 795                 800 


Ala Lys Lys Lys Pro Lys Lys Ile Thr Asp Glu Val Lys Glu Glu His 
                805                 810                 815     


Arg Ser Tyr Leu Glu Phe Gln Ser Trp Asn Lys Phe Glu Arg Glu Leu 
            820                 825                 830         


Arg Leu Val Arg Asn Gln Asp Ile Val Thr Trp Leu Leu Cys Met Glu 
        835                 840                 845             


Leu Phe Asp Asn Leu Lys Val Glu Gly Leu Asn Val Glu Glu Leu Gln 
    850                 855                 860                 


Lys Leu Arg Leu Lys Asp Ile Asp Thr Asp Thr Ala Lys Lys Asp Lys 
865                 870                 875                 880 


Asn Asn Ile Leu Asn Arg Ile Met Pro Met Gln Leu Pro Val Thr Val 
                885                 890                 895     


Tyr Glu Ile Asp Asp Ser His Asn Ile Val Lys Asp Lys Pro Leu His 
            900                 905                 910         


Thr Val Tyr Ile Glu Glu Thr Lys Thr Lys Leu Leu Lys Gln Gly Asn 
        915                 920                 925             


Phe Lys Ala Leu Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe 
    930                 935                 940                 


Val Asp Thr Ser Ser Glu Ala Glu Leu Lys Asp Lys Pro Ile Ser Lys 
945                 950                 955                 960 


Ser Val Val Glu Tyr Glu Leu Gly Glu Tyr Gln Asn Ala Arg Ile Glu 
                965                 970                 975     


Thr Ile Lys Asp Met Leu Leu Leu Glu Glu Thr Leu Ile Glu Lys Tyr 
            980                 985                 990         


Lys Thr Leu Pro Thr Asn Asn Phe  Ser Ala Met Leu Asn  Ala Trp Leu 
        995                 1000                 1005             


Glu Gly  Lys Asp Glu Ser Asp  Lys Ala Arg Phe Gln  Asn Asp Val 
    1010                 1015                 1020             


Asp Leu  Leu Val Ala Val Arg  Asn Ala Phe Ser His  Asn Gln Tyr 
    1025                 1030                 1035             


Pro Met  Arg Asn Arg Ile Ala  Phe Ala Asn Ile Asn  Pro Phe Ser 
    1040                 1045                 1050             


Leu Ser  Ser Ala Asn Thr Ser  Glu Glu Lys Lys Leu  Asp Ile Ala 
    1055                 1060                 1065             


Asn Gln  Leu Lys Asp Lys Thr  His Lys Thr Ile Lys  Lys Ile Ile 
    1070                 1075                 1080             


Glu Ile  Glu Lys Pro Ile Glu  Thr Lys Glu 
    1085                 1090             


<210>  2111
<211>  1126
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2111

Met Glu Thr Leu Leu Thr Pro Thr Glu Asn Lys Tyr Arg Thr Ile Asn 
1               5                   10                  15      


Asp Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Ser Met Ala Arg Leu Asn 
            20                  25                  30          


Val Phe Asn Ile Ser Asn His Ile Ala Lys Glu Phe Gly Gln Ser Leu 
        35                  40                  45              


Leu Glu Glu Glu Gly His Ile Lys Asn Ser Phe Leu Cys Asp Lys Asn 
    50                  55                  60                  


Asn Lys Lys Val Asn Trp Asn His Val His Ala Lys Ala Arg Arg Phe 
65                  70                  75                  80  


Leu Ser Ile Leu Lys Val Phe Asp Ala Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Leu Lys Ile Ile Glu Trp Glu Gly Lys Asp Phe Ser Leu Met Gly Asp 
            100                 105                 110         


Thr Leu Lys Ile Val Phe Arg Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Phe Tyr Ser Thr Glu Lys Gly Thr Ser Arg Lys Ile Lys Val 
    130                 135                 140                 


Ser Glu Glu Leu Ala Glu Phe Leu Lys Thr Asn Phe Arg Arg Ala Ile 
145                 150                 155                 160 


Glu Tyr Thr Lys Glu Arg Phe Lys Gly Gly Leu Ile Glu Glu Asp Phe 
                165                 170                 175     


Asn Leu Val Ala Ser Arg Lys Val Val Arg Asp Asp Leu Ala Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ala Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Thr Gly Leu Lys Gly Thr Gln Asn 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro His Asp Arg Phe Gln Ser Asp Asn Thr Arg Gln Ala Phe Ser 
                245                 250                 255     


Leu Asp Leu Ile Asn Glu Leu Asn Arg Cys Pro Lys Val Leu Tyr Asn 
            260                 265                 270         


Val Ile Thr Glu Glu Gly Lys Gln Leu Phe Arg Pro Gln Leu Glu Asp 
        275                 280                 285             


Leu Glu Ile Lys Asn Leu Ile Lys Asn Ser Thr Asn Asn Glu Glu Glu 
    290                 295                 300                 


Ile Asp Asn Tyr Asp Glu Tyr Ile Glu Ala Leu Thr Lys Arg Ile Arg 
305                 310                 315                 320 


His Thr Asn Arg Phe Ser Asp Phe Ala Leu Gln Phe Ile Asp Glu Thr 
                325                 330                 335     


Asp Val Phe Lys Lys Phe Arg Phe Gln Ile Asp Leu Gly Lys Leu Leu 
            340                 345                 350         


Val Asp Glu Tyr Asp Lys Ser Phe Asn Gly Glu Glu Val Glu Arg Lys 
        355                 360                 365             


Ile Ile Val Asn Ala Lys Ala Phe Arg Lys Leu Asn Ser Tyr Gly Thr 
    370                 375                 380                 


Glu Asp Glu Thr Leu Lys Leu Ile Glu Asn Gly Gln Gly Ser Lys Arg 
385                 390                 395                 400 


Phe Glu Gln Phe Ala Pro His Tyr Asn Thr Glu Asn Asn Lys Ile Gly 
                405                 410                 415     


Leu Ser Gly Lys Glu Leu Ile Ala Lys Leu Arg Pro Asn Ser Lys Gly 
            420                 425                 430         


Glu Ala Gly Lys Lys Leu His Gln Pro Leu Pro Glu Ala Phe Leu Ser 
        435                 440                 445             


Leu Lys Glu Leu Pro Lys Ile Ile Leu Leu Asn Tyr Leu Leu Pro Asp 
    450                 455                 460                 


Glu Pro Glu Lys Leu Ile Asn Asp Phe Ile Leu Val Asn Asn Ser Lys 
465                 470                 475                 480 


Leu Met Asn Met Ser Phe Ile Lys Glu Val Lys Ser Leu Leu Pro Lys 
                485                 490                 495     


Glu Trp Asn Glu Phe Lys Lys Arg Ser Asp Thr Lys Lys Gln Arg Ala 
            500                 505                 510         


Tyr Asn Glu Lys Ala Leu Ala Tyr Leu Leu His Arg Lys Gln Ile Leu 
        515                 520                 525             


Asn Gln Val Leu Ala Ala Tyr Gln Leu Asn Asp Lys Gln Ile Pro Arg 
    530                 535                 540                 


Arg Ile Leu Asp Tyr Trp Leu Asn Ile Val Asp Val Val Glu Gly Arg 
545                 550                 555                 560 


Ser Val Ser Asp Arg Ile Lys Met Met Lys Arg Asp Cys Met Ser Arg 
                565                 570                 575     


Leu Lys Ala Met Ala Lys Phe Lys Glu Asp Arg Asn Arg Asn Lys Ile 
            580                 585                 590         


Pro Lys Ile Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile Val Asp 
        595                 600                 605             


Met Val Val Gly Glu Glu Lys Lys Gln Lys Ile Thr Ser Phe Tyr Tyr 
    610                 615                 620                 


Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Pro Glu Lys Lys 
625                 630                 635                 640 


Gln Leu Phe Ile His Thr Val Ile Asn Glu Leu Lys Leu Asn Glu Gln 
                645                 650                 655     


Gly Gly His Pro Phe Leu His Lys Leu Asn Leu Gln Gln Ile Lys Asn 
            660                 665                 670         


Thr Ser Gly Phe Tyr Glu Ile Tyr Leu Gln Glu Lys Gly Gln Lys Met 
        675                 680                 685             


Val Ser Glu Lys Asn Phe Arg Thr Gly Arg Thr Ile Glu Thr Asp Lys 
    690                 695                 700                 


Ser Trp Met Ala Leu Thr Phe Tyr Lys Lys Glu Trp Asp Glu Lys Val 
705                 710                 715                 720 


Gly Lys Gln Leu Thr Val Val Arg Leu Pro Glu Asn Lys Ser Asn Ile 
                725                 730                 735     


Pro Phe Ser Leu Arg Leu Leu Glu Glu Lys Thr Val Tyr Thr Leu Glu 
            740                 745                 750         


Gln Trp Leu His Asn Val Thr Lys Gly Lys Lys Gln Asn Asp Thr Arg 
        755                 760                 765             


Gln Pro Val Asn Leu Pro Thr Asn Leu Phe Asp Glu Arg Leu Thr Val 
    770                 775                 780                 


Leu Leu Arg Gly Glu Leu Asp Lys Lys Gln Ile Ser Tyr Ala Pro Asn 
785                 790                 795                 800 


Ala Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Lys Ser Arg Asn Asp 
                805                 810                 815     


Ser Val Gln Ser Phe Tyr Lys Ala Glu Arg Glu Tyr Glu Ile Phe Gly 
            820                 825                 830         


Glu Lys Val Asn Phe Met Pro Asp Ser Lys Glu Arg Phe Ala Asp Tyr 
        835                 840                 845             


Tyr Gln His Ala Leu Thr Ala Ala Trp Gln Lys Lys Arg Lys Glu Arg 
    850                 855                 860                 


Ile Gln Gln Gln Lys Gln Asp Arg Arg Leu Pro Asp Ile Ser Phe Asp 
865                 870                 875                 880 


Gln Val Glu Lys Thr Phe Lys Gln Thr Ile Ala Glu Thr Glu Lys Glu 
                885                 890                 895     


Ile Arg Ile Val Gln Glu Glu Asp Arg Met Met Leu Leu Met Leu Glu 
            900                 905                 910         


Thr Leu Met Glu Asn Gly Lys Asp Leu Lys Leu Lys Leu Ser Gly Ile 
        915                 920                 925             


Asp Thr Leu Leu Asn Ala Thr Thr Glu Val Lys Gln Leu Val Ser Gly 
    930                 935                 940                 


Lys Leu Ser Phe Asn Gly Ser Gly Glu Leu Ile Lys Gly Lys Thr Asn 
945                 950                 955                 960 


Pro Glu Ile Ser Lys Thr Ile Thr Val Ala Arg Lys Arg Lys Asp Tyr 
                965                 970                 975     


Ser Met Leu Arg Lys Phe Val Phe Asp Arg Arg Leu Pro Glu Leu Phe 
            980                 985                 990         


Glu Tyr Phe Ala Glu Glu Glu Ile  Pro Ile Glu Val Leu  Lys Asp Glu 
        995                 1000                 1005             


Leu Asp  Ala Tyr Asn Lys Ala  Lys His Glu Val Phe  Asp Thr Val 
    1010                 1015                 1020             


Phe Glu  Leu Glu Glu Lys Ile  Ile Thr Leu Asp Ala  Asp Gly Ile 
    1025                 1030                 1035             


Arg Gln  Leu Phe Ile Asp Asp  Ala Gly Gln Pro Val  Thr Gly Asn 
    1040                 1045                 1050             


Ile Gln  His Lys Pro Tyr Val  Ile Trp Leu Lys Asn  Asn Gly Thr 
    1055                 1060                 1065             


Ile Asp  Asp Asn Thr Leu Thr  Phe Leu Asn Met Val  Arg Asn Cys 
    1070                 1075                 1080             


Phe Ser  His Asn Gln Tyr Pro  Gln Lys Lys Thr Met  Glu Leu Leu 
    1085                 1090                 1095             


Ile Gly  Gln Trp Glu Pro Asn  Arg Phe Ala Leu Thr  Ile Ala Gln 
    1100                 1105                 1110             


Thr Tyr  Lys Arg Lys Ile Asn  Ser Ile Met Lys His  Leu 
    1115                 1120                 1125     


<210>  2112
<211>  1140
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2112

Met Glu Asn Asp Gln Gln Ile Leu Glu Asn Arg Arg Arg Thr Leu Ala 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Ser Asn His Leu Ala Thr Ser Phe Glu Gln Lys Ala 
        35                  40                  45              


Leu His Glu Glu Gly Gln Ile Pro Ala Ser Phe Leu Cys Asn Lys Ser 
    50                  55                  60                  


Ile Lys Lys Ile Asn Trp Asn His Val Tyr Ser Lys Ala Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Ile Phe Asp Ala Asp Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Arg Glu Thr Ser Asp Lys Glu Gly Lys Asp Phe Thr Ala Met Asn Glu 
            100                 105                 110         


Thr Leu Lys Leu Val Phe Asp Glu Leu Gln Ala Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Ala Asp Ser Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Val Glu Leu Ala Asp Phe Leu Thr Val Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Ala Asp Asp Asp Tyr 
                165                 170                 175     


Ala Val Val Glu Ser Lys Gln Ile Val Thr Pro Asp Asn Gln Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Ile Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Val Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Leu Ala Tyr Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asp Leu Arg Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Glu 
            260                 265                 270         


Val Ile Thr Glu Glu Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Glu Glu Glu Arg 
    290                 295                 300                 


Glu Lys Ile Leu Asp Glu Ile Asp Tyr Glu Asp Tyr Ile Glu Ser Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg His Ser Asn Arg Phe Pro Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Glu Lys Tyr Asn Lys Gln Phe Asp Gly Glu 
        355                 360                 365             


Ala Thr Glu Arg Lys Val Val Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asn Gln Glu Thr Val Glu Leu Lys Ile Asp Ser Ala 
385                 390                 395                 400 


Gln Arg Thr Asn Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Glu Ala Arg Leu Leu 
            420                 425                 430         


Thr Lys Ala Lys Pro Glu Ser Lys Val Ser Tyr Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Lys Ala Glu Glu Met Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Lys Val Asn Asp Ser Gln Leu Met Asn Met Gln Phe Ile Asp Glu 
                485                 490                 495     


Ile Lys Glu Gln Leu Pro Ala Asp Trp Asn Glu Phe Gly Lys Arg Ser 
            500                 505                 510         


Asp Ser Lys Lys Lys Lys Ala Tyr Thr Asn Ala Ala Arg Gln Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Lys Val Leu Ala Asn Tyr Gln Leu 
    530                 535                 540                 


Asn Asp Lys Gln Val Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Val 
545                 550                 555                 560 


Lys Glu Val Asp Asp Ser Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Met Glu Lys His Lys Val 
            580                 585                 590         


Asp Lys Ser Ala Arg Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Thr Asp Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Tyr 
625                 630                 635                 640 


Ala Asp Asn Glu Lys Lys Ala Thr Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Lys Asp Gly His Pro Phe Leu Ala Asn Ile Asn 
            660                 665                 670         


Leu Arg Gln Ile Arg Lys Thr Ser Gln Leu Tyr Glu Leu Tyr Leu Val 
        675                 680                 685             


Glu Lys Ala Asn Lys Gln Val Lys Lys Met Asn Pro Lys Thr Gln Arg 
    690                 695                 700                 


Thr Asn Asn Val Asp Glu Ser Trp Met Met Lys Ser Phe Tyr Ala Lys 
705                 710                 715                 720 


Glu Trp Asn Glu Glu Met Gly Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Thr Asn Ile Pro Phe Thr Ile Arg Gln Trp Glu Glu Lys 
            740                 745                 750         


Glu Lys His Asn Leu Gln Ala Trp Leu His Asn Ile Thr Lys Gly Lys 
        755                 760                 765             


Thr Ser Lys Asp Gly Lys Lys Ala Val Asp Leu Pro Thr Asn Leu Phe 
    770                 775                 780                 


Asp Asp Thr Leu Cys Glu Leu Leu Arg Glu Ala Leu Ile Asn Glu Gly 
785                 790                 795                 800 


Ile Asp Ala Thr Pro Thr Thr Lys Tyr Asn Glu Leu Leu Lys His Trp 
                805                 810                 815     


Trp Thr Ala Arg Glu Asp Ser Thr Gln Asp Phe Tyr Leu Ser Glu Arg 
            820                 825                 830         


Gln Tyr Asp Ile Tyr Asp Glu Lys Val Cys Phe Thr Ile Asn Ser Ser 
        835                 840                 845             


Ala His Phe Ala Asp Tyr Tyr Ala Pro Ala Leu Ser Lys Ala Tyr Ser 
    850                 855                 860                 


Arg Leu Arg Ala Glu Arg Asp Val Ala Arg Arg Thr Asp Lys Arg Leu 
865                 870                 875                 880 


Pro Pro Val Glu Arg Lys Asp Val Glu Arg Val Phe Lys Asn Thr Ile 
                885                 890                 895     


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
            900                 905                 910         


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asn Gln Gln Gln Leu Lys 
        915                 920                 925             


Leu Ser Lys Met Asp Ser Leu Leu Asn Glu Thr Lys Arg Ile Glu Gln 
    930                 935                 940                 


Val Ile Asn Thr Gln Leu Ser Phe Asp Gln Lys Gly Lys Glu Ile Lys 
945                 950                 955                 960 


Asp Lys Thr Asn Leu Glu Ile Val Lys Thr Ile Val Ala Glu Arg Lys 
                965                 970                 975     


Gln Lys Asn Tyr Thr Glu Met Arg Lys Tyr Val His Asp Arg Arg Leu 
            980                 985                 990         


Pro Glu Leu Phe Glu Tyr Ile Asp  Gly Asn Glu Leu Pro  Leu Asp Met 
        995                 1000                 1005             


Leu Leu  Asn Glu Leu Arg Ala  Tyr Asn Thr Ala Lys  Gln Val Val 
    1010                 1015                 1020             


Phe Asp  Thr Val Phe Ala Leu  Glu Lys Lys Ile Ile  Glu Thr Asp 
    1025                 1030                 1035             


Pro Glu  Gly Leu Lys Gln Leu  Asn Val Ser Lys Asp  Gly Gln Ile 
    1040                 1045                 1050             


Gln Thr  Gly Asn Ile Gln His  Lys Pro Tyr Val Gln  Trp Leu Glu 
    1055                 1060                 1065             


Asn Lys  Gly Leu Ile Thr Asp  Lys Asp Lys Gln Phe  Ile Asn Met 
    1070                 1075                 1080             


Val Arg  Asn Ser Phe Ser His  Asn Gln Phe Pro Gln  Arg Ser Thr 
    1085                 1090                 1095             


Val Glu  Leu Leu Met Pro Val  Trp Gln Asn Thr Asn  Ile Ala Leu 
    1100                 1105                 1110             


Gln Ile  Ala Arg Glu Tyr Gln  Gln Leu Ile Val Asp  Ile Ile Glu 
    1115                 1120                 1125             


Lys Ser  Leu His Pro His Lys  Gln His Gln Met Val  
    1130                 1135                 1140 


<210>  2113
<211>  986
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2113

Met Lys Thr Asn Gln Pro Lys Thr Ile Tyr Tyr Asn Trp Lys Asp Lys 
1               5                   10                  15      


Glu Asp Phe Ala Tyr Phe Ala Phe Tyr Thr Ser Gln Ala Leu Asn Asn 
            20                  25                  30          


Thr Ser Ile Ile Leu Lys Asn Ile Ser Glu Ile Ile Glu Asn Lys Val 
        35                  40                  45              


Asp Lys Thr Asn Asp Asp Asn Gln Leu Phe Ser Asn Ala Gln Val Ile 
    50                  55                  60                  


Lys Ile Leu Glu Ser Asn Asn Ser Val Ala Gln Lys Ser Val Ile Asn 
65                  70                  75                  80  


Leu Leu Asp Ser Asn Leu Pro Phe Ser Val Lys Ser Ile Ser Asp Pro 
                85                  90                  95      


Phe Leu Val Lys Asn Arg Leu Ser Tyr Phe Leu Trp Leu Leu Lys Asn 
            100                 105                 110         


Phe Arg Asn Glu Tyr Ala His Tyr His Glu Arg Glu Leu Asp Ser Arg 
        115                 120                 125             


Thr Thr Leu Asp Arg Glu Glu Asp Phe Lys Lys Arg Glu Asn Leu Asn 
    130                 135                 140                 


Lys Arg Phe Ser Lys Tyr Asp Phe Ala Asp Glu Leu Leu Lys Leu Lys 
145                 150                 155                 160 


Lys Ser Ala Val Glu Glu Leu Glu Lys Arg Leu Lys Ile Asn Asn Lys 
                165                 170                 175     


Glu Leu Glu Ser Asp Ser Val Tyr Lys Ser Phe Lys Asn Arg Phe Leu 
            180                 185                 190         


Lys Ile Ser Ser Arg Gln Asn Phe Thr Glu Glu Asp Phe Ile Phe Phe 
        195                 200                 205             


Leu Cys Leu Phe Leu Ser Thr Lys Glu Thr Met Gln Leu Leu Asn Gly 
    210                 215                 220                 


Ile Lys Gly Lys Lys Asn Thr Thr Thr Glu Glu Phe Gln Trp Ile Arg 
225                 230                 235                 240 


Arg Val Phe Thr Ile Phe Asn Ala Lys Arg Phe Gln Asn Lys Ile Lys 
                245                 250                 255     


Ser Asp Asn Pro Lys Glu Ala Phe Ile Leu Asn Ile Val Asn Asp Leu 
            260                 265                 270         


Ala Lys Ile Pro Ile His Leu Lys Lys Tyr Leu Thr Glu Glu Ala Lys 
        275                 280                 285             


Glu Lys Leu Ile Tyr Thr Val Gln Glu Thr Glu Asp Glu Glu Gly Asn 
    290                 295                 300                 


Ile Leu Glu Gln Lys Ser Glu Ala Val Thr Lys His Asp Glu Met Phe 
305                 310                 315                 320 


Ser Tyr Arg Cys Leu Gln Tyr Leu Glu Leu Phe Gly Phe Ala Lys Asn 
                325                 330                 335     


Ile Asn Phe Asn Ile Asn Leu Gly Lys Val Phe Ile Asn Lys Pro Tyr 
            340                 345                 350         


Lys Lys Thr Ile Ile Asn Asp Glu Tyr Asp Arg Phe Leu Asp Lys Glu 
        355                 360                 365             


Ile His Thr Phe Gly Lys Leu Lys Asp Phe Asp Asp Ser Tyr Phe Glu 
    370                 375                 380                 


Gly Tyr Ile Glu Arg Lys Glu Thr Glu Asn Gly Val Val Thr Thr Phe 
385                 390                 395                 400 


Lys Gln Pro Leu Lys Phe Tyr Ser Pro Lys Tyr His Phe Ser Asn Asn 
                405                 410                 415     


Arg Ile Gly Ile Lys Leu Tyr Asn Lys Asn Leu Lys Leu Glu Leu Lys 
            420                 425                 430         


Glu Tyr Asp Glu Asp Gly Lys Phe Val Val Ile Asn Asn Gln Pro Asp 
        435                 440                 445             


Tyr Phe Leu Ser Glu Asn Ala Ile Pro Tyr Phe Thr Tyr Cys Met Ile 
    450                 455                 460                 


Asn Phe Gly Glu Asp Lys Thr Leu Gly Val Ile Lys Asn Phe Glu Thr 
465                 470                 475                 480 


Asn Phe Lys Arg Phe Leu Asn Asp Val Ser Ile Gly Lys Ser Ile Lys 
                485                 490                 495     


Leu Gln Glu Ile Glu Gln Asn Tyr Ser Leu Lys Ile Gly Trp Ile Pro 
            500                 505                 510         


Ser Leu Ile Arg Asp Asn Leu Phe His Asp Asn Asp Lys Thr Phe Glu 
        515                 520                 525             


Glu Val Val Lys Glu Lys Ile Asn Ser Leu Lys Glu Glu Thr Gln Lys 
    530                 535                 540                 


Leu Ile Glu Asn Asn Asn Lys Lys Pro Glu Asp Arg Asp Arg Asn Ile 
545                 550                 555                 560 


Lys Phe Ser Phe Lys Lys Gly Asp Leu Ala Thr Phe Val Ala Lys Asp 
                565                 570                 575     


Ile Ile Tyr Phe Met Glu Ser Lys Glu Glu Ile Val Asn Gly Lys Lys 
            580                 585                 590         


Val Val Ser Lys Leu Ser Ser Ile Glu Tyr Asp Val Leu Gln Ser Lys 
        595                 600                 605             


Leu Ala Phe Tyr Gly Lys His Glu Glu Asp Leu Lys Leu Leu Phe Lys 
    610                 615                 620                 


Lys Trp Asn Leu Asn Glu Arg His Pro Phe Leu Lys Asp Val Ser Met 
625                 630                 635                 640 


Glu Lys Val Glu Asp Arg Arg Gly Phe Lys Arg Gln Ile Gly Ile Lys 
                645                 650                 655     


Lys Phe Phe Lys Asn Tyr Ile Tyr Gln Arg Lys Tyr Trp Leu Asn Asp 
            660                 665                 670         


Leu Lys Leu Glu Ile Asn Lys Glu Asn Tyr His Phe Val Asp Asp Tyr 
        675                 680                 685             


Lys Val Cys Lys Asn Asp Thr Gln Ile Lys Ala Tyr Ala Ser Asn Leu 
    690                 695                 700                 


Leu Asn His Thr Ile Tyr Leu Pro Asn Asp Leu Phe Ser Asp Leu Ile 
705                 710                 715                 720 


Leu Glu Asn Ser Asn Phe Ala Val Glu Lys Ala Asn Thr Asn Phe Leu 
                725                 730                 735     


Ile Ser Lys Asn Leu Glu Tyr Phe Gly Asn Gln Trp Phe Tyr Asn Lys 
            740                 745                 750         


Glu Asn Tyr Gln Gln Gly Leu Asp Thr Tyr Gln Ser His Leu Arg Asp 
        755                 760                 765             


Lys Gln Ile Arg Lys Ala Ile Thr Leu Asp Arg Leu Tyr Trp Asn Met 
    770                 775                 780                 


Leu Lys Ile Asn Thr Gln Ile Pro Glu Phe Ser Gln Ile Phe Glu Gln 
785                 790                 795                 800 


Asn Asn Leu Ala Ala Tyr Asn Ser Glu Gln Thr Leu Leu Glu Lys Gln 
                805                 810                 815     


Ile Arg Met Ser Ser Asn Phe Lys Leu Ala Lys Glu Asp Phe Arg Tyr 
            820                 825                 830         


Leu Asp Phe Asp Arg Asp Phe Glu Ile Lys Ile Glu Gly Tyr Arg Lys 
        835                 840                 845             


Ile Lys Asp Phe Gly Ile Phe Arg His Leu Ile Lys Asp Arg Arg Val 
    850                 855                 860                 


Pro Ser Ile Leu Ala Phe Tyr Thr Lys Tyr Lys Lys Leu Gly Ser Ile 
865                 870                 875                 880 


Asn Glu Glu Ile Ile Arg Asn Glu Ile Leu Asp Phe Glu Tyr Tyr Lys 
                885                 890                 895     


Ile Ser Ile Leu Lys Arg Val Leu Glu Ile Asp Lys Gln Ile Tyr Asn 
            900                 905                 910         


Asn Leu Ile Gly Lys Asn Ile Ser Ile His Glu Lys Phe Ser Glu Asn 
        915                 920                 925             


Val Asn Lys Leu Tyr Leu Glu Asn Gln Lys Leu Ala Asn Lys Ile Ile 
    930                 935                 940                 


Glu Ile Arg Asn Lys Leu Leu His Asn Lys Val Pro Glu Ile Asn Leu 
945                 950                 955                 960 


Glu Asn Ile Gln Glu Thr Phe Ser Glu Thr Leu Phe Leu Glu Met Glu 
                965                 970                 975     


Lys Ser Cys Asn Glu Leu Glu Arg Leu Ile 
            980                 985     


<210>  2114
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2114

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2115
<211>  1199
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2115

Met Asn Thr Phe Ile Asp Ser Phe Ile Arg Arg Val Gln Ile Gln Asn 
1               5                   10                  15      


Gln Asn Gln Ser Trp Pro Lys Arg Pro Lys Tyr Val Arg Pro Val Glu 
            20                  25                  30          


Asn Ile Arg Pro Asp Asp Leu Ala Phe Gln Ser His Phe Thr Ala Tyr 
        35                  40                  45              


Leu Asn Met Ala Arg Gln Asn Cys Cys Ile Ile Leu Gly His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Gly Phe Lys Ala Ser Ser Val Lys Asp Thr Thr Leu Thr 
65                  70                  75                  80  


Ser Ser Pro Leu Leu Gly Gln Asn Gly Leu Leu Ser Pro Lys Lys Glu 
                85                  90                  95      


Val Ser Asp Leu Ile Arg Gly Arg Leu Leu Ser Ala Phe Pro Met Leu 
            100                 105                 110         


Asp Pro Met Ile Arg Tyr Arg Lys Ala Val Asp Lys Glu Lys Asp Asp 
        115                 120                 125             


Tyr Ala Arg Ile Ile Ile Thr Ser Glu Asp Val Ser Glu Met Leu Arg 
    130                 135                 140                 


Asp Leu Leu Asp Val Leu Ser Tyr Tyr Arg Asp Met Ala Ser His Val 
145                 150                 155                 160 


Val Phe Asn Asp Asp Arg Ser Val Ser Ala Glu Phe Ala Ser Lys Glu 
                165                 170                 175     


Lys Lys Val Ala Glu Cys Leu Asn Tyr Met Met Thr Val Ser Leu Arg 
            180                 185                 190         


Ile Val Lys Asp Arg Phe Ser Leu Ala Val Ser Asp Leu Asp Phe Tyr 
        195                 200                 205             


Asn Arg Asn Arg Tyr Met Met Val Asn Arg Lys Pro Leu Leu Asn Ala 
    210                 215                 220                 


Gly Phe Ala His Ala Val Arg Thr Glu Asp Tyr Arg Leu Thr Leu Met 
225                 230                 235                 240 


Gly Leu Val Leu Leu Cys Cys Gln Phe Ile Glu Lys Gln Tyr Ala Ser 
                245                 250                 255     


Met Phe Phe Asp Ala Leu Asp Lys His Ser Asn Gly Ala Arg Phe Tyr 
            260                 265                 270         


Gly Ile Ala Asp Ala Met Pro Met Val Asn Val Gly Thr Lys Asp Lys 
        275                 280                 285             


Pro Lys Lys Ile Pro Met Tyr Thr Gly Asp Glu Ala Gln Lys Gln Val 
    290                 295                 300                 


Gln Lys Gln Arg Met Ala Leu Arg Glu Ala Tyr Ser Val Tyr Arg Val 
305                 310                 315                 320 


Arg Ile Pro Lys Glu Arg Leu Glu Ser Thr Arg Ser Asp Met Ala Leu 
                325                 330                 335     


Ala Leu Asp Ile Leu Asn Glu Leu Gly Lys Cys Pro Glu Glu Leu Phe 
            340                 345                 350         


Glu His Leu Ser Pro Glu Asp Arg Glu Ser Phe Lys Asn Glu Glu Gly 
        355                 360                 365             


Val Leu Met Lys Arg Tyr Ser Asp Arg Phe Pro Gln Leu Ala Leu Arg 
    370                 375                 380                 


Trp Leu Asp Glu Asn Glu Lys Phe Asn Asn Leu Arg Phe His Val Thr 
385                 390                 395                 400 


Phe Gly Lys Tyr Arg Trp Leu Phe Cys Gln Asp Lys Lys Cys Ala Asp 
                405                 410                 415     


Gly Ser Val Arg Pro Arg Trp Leu Gln Lys Glu Leu Asn Gly Phe Gly 
            420                 425                 430         


Arg Ile Gln Thr Val Glu Arg Lys Arg Thr Gly Leu Glu Pro Gly Trp 
        435                 440                 445             


Asp Gly Thr Gly Leu Ile Arg Lys Phe Glu Glu Val Val Thr Asp Glu 
    450                 455                 460                 


Val Gln Lys Glu Pro Tyr Ile Thr Asp Phe Arg Thr Gln Tyr Leu Phe 
465                 470                 475                 480 


Asn Arg Asp Lys Ile Gly Ile Ser Leu Ser Glu Tyr Met Pro Gly Ile 
                485                 490                 495     


Gly Asp Ile His Ser Gly Lys Glu Trp Gly Lys His Ala Gly Val Pro 
            500                 505                 510         


Asp Phe Tyr Leu Ser Val Tyr Asp Ile Pro Ala Met Leu Phe Leu Thr 
        515                 520                 525             


Trp Leu Leu Gly Lys Asn Ser Ser Ala Val Glu Lys Leu Leu Ala Asn 
    530                 535                 540                 


Cys Lys Ala Ala Tyr Met Lys Leu Phe Asp Asp Leu Ala Lys Gly Lys 
545                 550                 555                 560 


Trp Glu Gly Glu Arg Asn Val Ser Asp Tyr Cys Ala Gly Glu Gly Thr 
                565                 570                 575     


Val Arg Tyr Thr Leu Arg Trp Tyr Asp Val Pro Met Lys Ile Arg Arg 
            580                 585                 590         


Lys Met Pro Leu Leu Gly Gly Asp Arg Asp Phe Glu Glu Lys Lys Ser 
        595                 600                 605             


Phe Glu Thr Leu Ala Gln Glu Ala Leu Thr Arg Met Leu Gln Arg Thr 
    610                 615                 620                 


Glu Asn Gln Leu Glu Lys Phe Asp Arg Asp Leu Ala Ala Ala Arg Asp 
625                 630                 635                 640 


Leu Lys Ala Asn Lys Gln Gly Lys Asp Arg Phe Val Asp Ile Arg Ala 
                645                 650                 655     


Gly Ser Leu Ala Thr Phe Leu Ala Arg Asp Ile Val Arg Leu Met Pro 
            660                 665                 670         


Val Ser Asp Asn Gly Arg Asn Lys Pro Thr Gly Leu Asn Tyr Ser Ile 
        675                 680                 685             


Val Gln Lys Ala Ile Ala Thr Tyr Lys Pro Ser Glu Gly Gly Leu Asp 
    690                 695                 700                 


Thr Leu Thr Gly Val Phe Arg Asp Ala Arg Ile Ile Gly Val Lys Gly 
705                 710                 715                 720 


Gly Ser His Pro Phe Leu Glu Arg Leu Leu Val Glu Lys Lys Pro Ser 
                725                 730                 735     


Ser Val Leu Ala Leu Tyr Arg His Tyr Leu Glu Tyr Arg Lys Glu Tyr 
            740                 745                 750         


Leu Lys Lys Ala Leu Glu Asp Glu Asn Lys Ala Glu Leu Lys Asn Leu 
        755                 760                 765             


Pro Phe Leu Lys Ser Gly Arg Gln Lys Tyr Ala Val Asp Gln Ala Asp 
    770                 775                 780                 


Tyr Ala Arg Arg Leu Ala Glu Ser Tyr Arg Asn Cys Pro Ile Tyr Leu 
785                 790                 795                 800 


Pro Thr Gly Ile Phe Thr Asp Met Leu Lys Asp Gln Leu Ala Lys Ile 
                805                 810                 815     


Asp Val Met Lys Pro Val Leu Glu Asn Asp Lys Val Asn Ala Ser Tyr 
            820                 825                 830         


Leu Ile Ala Gln Tyr Phe Glu Lys Val Glu His Asp Ser Glu Gln Pro 
        835                 840                 845             


Leu Tyr Arg Leu Lys Arg Asn Tyr Arg Val Phe Asp Leu Leu Glu Phe 
    850                 855                 860                 


Thr Asp Glu Pro Lys Tyr Trp Arg Leu Asn Glu Arg Ser Asp Lys Ala 
865                 870                 875                 880 


Gly Lys Tyr Gly Leu Ala Lys Arg Asn Ile Phe Trp Asn Arg Met Gly 
                885                 890                 895     


Glu Tyr Tyr Lys Gly Leu Lys Lys Phe Tyr Lys Gly Tyr Glu Ser Lys 
            900                 905                 910         


Arg Thr Ala Val Asp Trp Arg Glu Lys Leu Lys Ile Val Glu Ala Glu 
        915                 920                 925             


His Ala Met Trp Asn Arg Leu Lys Asp Ala Ser Gly Glu Ala Arg Leu 
    930                 935                 940                 


Lys Met Lys Asp Gly Val Phe Tyr Ser Arg Leu Leu Ser Ala Arg Lys 
945                 950                 955                 960 


Glu Tyr Asp Asp Cys Glu Arg Ala Leu Arg Arg Leu Lys Val Gln Asp 
                965                 970                 975     


Ile Val Leu Phe Leu Ala Ala Arg Glu Thr Leu Ile Leu Pro Lys Asp 
            980                 985                 990         


Lys Val Phe Arg Leu Lys Asn Leu  Ser Leu Ser Glu Gly  Asn Lys Asn 
        995                 1000                 1005             


Ile Leu  Ser Ser Ala Ile Asp  Glu Phe Ser Val Asp  Val Val Trp 
    1010                 1015                 1020             


Thr Glu  Lys Glu Gly Ala Ala  Lys Val Thr His Ser  Ala Ser Ile 
    1025                 1030                 1035             


Lys Glu  Asn Asp Val Val Ile  Lys Asn Tyr Gly Arg  Met Phe Arg 
    1040                 1045                 1050             


Leu Leu  His Asp Asp Arg Val  Lys Thr Leu Leu Pro  His Ile Tyr 
    1055                 1060                 1065             


Asp Ser  Ala Leu Ser Glu Asn  Ile Thr Gly Asp Arg  Ile Thr Val 
    1070                 1075                 1080             


Lys Asp  Asn Lys Val Ile Ile  Asp Lys Ser Leu Phe  Asp Glu Asp 
    1085                 1090                 1095             


Leu Met  Asn Tyr Asp Leu Arg  Arg His Glu Ile Cys  Glu Ile Ile 
    1100                 1105                 1110             


Leu Arg  Phe Glu Ala Ala Ser  Ile Lys Arg Phe Gly  Leu Asp Gly 
    1115                 1120                 1125             


Arg Val  Asp Phe Lys Ala Ala  Leu Asp Ala Leu Thr  Gly Arg Ser 
    1130                 1135                 1140             


Leu Leu  Asn Asp Glu Asp Ala  Arg Ile Leu Ser Ala  Ile Arg Asn 
    1145                 1150                 1155             


Ala Tyr  Asn His Asn Lys Tyr  Pro Ala Lys Gly Thr  Asp Val Lys 
    1160                 1165                 1170             


Val Asn  Val Met Ala Leu Pro  Lys Leu Thr Glu Asp  Leu Leu Arg 
    1175                 1180                 1185             


Ile Phe  Ser Asp Thr Gly Asn  Asn Arg Val Arg 
    1190                 1195                 


<210>  2116
<211>  1085
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2116

Met Lys Lys Glu Leu Asn Arg Glu Asp Val Phe Thr Gly Gly Lys Thr 
1               5                   10                  15      


Pro Glu Leu Thr Ile Tyr Tyr Asn Ile Ala Tyr Phe Arg Met Ala Gly 
            20                  25                  30          


Leu Ile Asn Ala Leu Cys Gly Asn Lys Leu Glu Arg Asp Lys Asp Ala 
        35                  40                  45              


Leu Glu Gln Phe Met Lys Ala Phe Ile Asn Gly Lys Gln Lys Leu Thr 
    50                  55                  60                  


Asp Met Gln Phe Val Lys Leu Cys Asp Tyr Leu Trp Lys Gly Tyr Lys 
65                  70                  75                  80  


Tyr Asp Lys Asn Arg Ser Glu Tyr Ser Leu Thr Glu Asn Asp Lys Thr 
                85                  90                  95      


Met Val Leu Lys Met Val Ala Lys Leu Gln Asp Ile Arg Asn Phe Gln 
            100                 105                 110         


Ser His Ile Trp His Asp Asn Lys Val Leu Val Phe Asp Ala Asp Leu 
        115                 120                 125             


Val Gln Phe Ile Lys Asn Lys His Leu Glu Ala Ile Asp Ala Gln Arg 
    130                 135                 140                 


Gln Arg Phe Ser Lys Glu Thr Glu Val Tyr Glu Lys Glu Asn Arg Glu 
145                 150                 155                 160 


Leu Lys Lys Lys Lys Asn Lys Glu Leu Leu Phe Asp Ile His Asp Gly 
                165                 170                 175     


Leu Gly Tyr Ile Thr Gly Glu Gly Arg Asn Phe Phe Leu Ser Phe Phe 
            180                 185                 190         


Leu Thr Arg Gly Glu Met Thr Arg Phe Leu Lys Gln Arg Lys Gly Cys 
        195                 200                 205             


Lys Arg Asp Asp Thr Pro Glu Tyr Lys Ile Lys His Leu Val Tyr Arg 
    210                 215                 220                 


His Phe Thr His Arg Asp Gly Ala Thr Arg Thr His Tyr Gly Tyr Glu 
225                 230                 235                 240 


Asp Asn Met Leu Asp Gln Leu Pro Asp Lys Gln Glu Phe Leu Thr Thr 
                245                 250                 255     


Arg His Thr Tyr Arg Leu Ile Asn Tyr Leu Asn Asp Ile Pro Glu Glu 
            260                 265                 270         


Val Thr Asn Pro Glu Leu Phe Pro Leu Phe Asn Thr Ile Ser Asn Gly 
        275                 280                 285             


Ile Leu Ile Lys Glu Ser Val Gly Thr Tyr Ile Ala Phe Ile Asn Lys 
    290                 295                 300                 


Met Pro Leu Leu Ser Asp Phe Glu Phe Ser Glu Val Trp Gly Lys Asp 
305                 310                 315                 320 


Gly Lys Pro Tyr Thr Asn Leu Val Glu Phe Tyr His Lys Thr Gln Pro 
                325                 330                 335     


Gly Phe Lys Phe Arg Thr Asp Leu Asn Ser Phe His Lys Ile Ile Leu 
            340                 345                 350         


Asn Leu Ile Arg Asp Glu Asn Tyr Thr Gly Phe Phe Thr Thr Gln Leu 
        355                 360                 365             


Asn Leu Phe Met Ala His Arg Glu Glu Leu Ile Leu Val Ile Ser Lys 
    370                 375                 380                 


Pro Leu Ile Thr Pro Asn Asp Leu Leu Leu Ile Glu Glu His Tyr Arg 
385                 390                 395                 400 


Tyr Lys Leu Lys Ala Asn Asp Phe Val Arg Glu Lys Leu Gly Glu Trp 
                405                 410                 415     


Lys Glu Lys Ile Glu Lys Gly Lys Trp Glu Lys Ala Asn Glu Gln Lys 
            420                 425                 430         


Asp Lys Leu Ile Asn Leu Leu Gly Gly Val Ile Glu Ile Thr Phe Tyr 
        435                 440                 445             


Asp Phe Tyr Trp Gln Lys Asp Glu Lys Pro Arg Asn Glu Asn Arg Phe 
    450                 455                 460                 


Met Glu Phe Ala Ile Arg Phe Met Ala Asp Phe Asn Leu Leu Pro Asp 
465                 470                 475                 480 


Cys Glu Trp Glu Val Glu Pro Leu Gln Ile Glu Asn Asp Leu Ile Ala 
                485                 490                 495     


Asn Arg Thr Ala Thr Pro Asp Leu Lys Lys Ser Gly Ser Gln Phe Met 
            500                 505                 510         


Asn Gln Leu Thr Asp Asn Tyr Arg Leu Lys Phe Asn Asp Gly Gln Ile 
        515                 520                 525             


Ala Phe Arg Tyr Gln Asn Gln Val Phe Ile Met Gly His Lys Ala Val 
    530                 535                 540                 


Lys Asn Leu Leu Ile Ala Cys Phe Asp Gly Lys Glu Lys Met Leu Asn 
545                 550                 555                 560 


Gly Phe Met Pro Ala Leu Leu Ala Asp Leu Lys Lys Ile Thr Asn Glu 
                565                 570                 575     


His Ile Leu Lys Asn His Gln Ala Leu Asn Thr Leu Ser Leu Leu Asn 
            580                 585                 590         


Asn Asp Ser Ile Pro Ser Tyr Ile Ser Arg Gln Trp Gly Glu Ala Glu 
        595                 600                 605             


Pro Ile Thr Asp Met Lys Lys Lys Ala Ile Ala Arg Met Asp Tyr Ile 
    610                 615                 620                 


Thr Gln Gln Phe Glu Ala Leu Ile Glu Asn His His Tyr Leu Asn Arg 
625                 630                 635                 640 


Ala Asp Lys Asn Arg Gln Ile Met Arg Cys Tyr Lys Phe Phe Glu Trp 
                645                 650                 655     


Gln Tyr Pro Gln Asn Ser Gln Phe Lys Phe Leu Arg Arg Asn Glu Tyr 
            660                 665                 670         


His Arg Met Ser Ile Tyr His Tyr Cys Leu Asp Lys Glu Gln His Lys 
        675                 680                 685             


Tyr Asp Lys Lys Gly His Asn Tyr Leu Tyr Asn Arg Leu Ile Lys Glu 
    690                 695                 700                 


Ser His Asn Glu Ser Gly Asn Ile Glu Gln His Leu Pro Tyr Gln Ile 
705                 710                 715                 720 


Arg Thr Met Leu Asn Asp Ala Lys Asp Phe Asn Asp Tyr Phe Leu Arg 
                725                 730                 735     


Ile Leu Asn Ala Thr His Lys Ile Leu Thr Asp Trp Lys Asn Gln Leu 
            740                 745                 750         


Lys Gln Gly Arg Glu Pro Asn Asn Tyr Tyr Leu Ser Arg Leu Gly Phe 
        755                 760                 765             


Thr Gly Gly Leu Thr Gln Lys Val Val His Thr Arg Leu Leu Pro Phe 
    770                 775                 780                 


Ser Ile His Pro Gly Ile Pro Val Ser Phe Phe Tyr Arg Thr Glu Met 
785                 790                 795                 800 


Asn Gln Asn Pro Ser Phe Asn Leu Ser Ala Lys Val Trp Asn Ser Glu 
                805                 810                 815     


Ser Pro Phe Arg Val Gly Leu Lys Glu Ser Asn Tyr Gln Tyr Ala Lys 
            820                 825                 830         


Tyr Leu Gly Leu Phe Asn Glu Ile Lys Thr Gln Arg Lys Ile Ile Gly 
        835                 840                 845             


Lys Met Asn Gln Leu Ile Ala Glu Asp Ala Leu Leu Trp Gln Ile Ala 
    850                 855                 860                 


Lys Lys Tyr Leu Asp Lys Cys His Pro Lys Phe Ser Glu Ile Ile Asn 
865                 870                 875                 880 


Gln Gln Val Asn Gly Lys Gln Pro Leu Asn Val Lys Ala Ile His Asp 
                885                 890                 895     


Thr Glu Leu Thr Ile Asp Phe Pro Val Asp Lys Asn Leu Tyr Gln Val 
            900                 905                 910         


Val Val Lys Met Lys Gln Leu Asp Asp Phe Met Phe Ile Asp Ser Lys 
        915                 920                 925             


Pro Val Leu Glu Lys Thr Ile Arg Tyr Met Ile Lys Asn Ser Leu Arg 
    930                 935                 940                 


Asp Lys Glu Tyr Gln Gln Arg Val Phe Ile Glu Thr Asn Pro Gly Val 
945                 950                 955                 960 


Phe Lys Ile Pro Tyr Asn Glu Val Val Glu Ala Met Arg Thr Ile Asn 
                965                 970                 975     


His Gln Ala Leu Thr Trp Ala Arg Leu Leu Leu Asp Trp Glu Ser Lys 
            980                 985                 990         


Thr Val Lys Thr Ile Pro Glu Ala  Asp Lys Lys Ala Lys  Leu Gln Glu 
        995                 1000                 1005             


Ala Tyr  Asn Lys Arg Gln Pro  Ala Phe Phe Asn Phe  Asn Asp Ile 
    1010                 1015                 1020             


Cys Arg  Tyr Ala Asp Asp Gly  Lys Gln Leu Lys Asp  Leu Arg Asn 
    1025                 1030                 1035             


Lys Thr  Phe His Thr Glu Val  Pro Glu Thr Trp Thr  Tyr Asp Glu 
    1040                 1045                 1050             


Met Arg  Glu Asn Lys Thr Ile  Lys Met Val Leu Gly  Ile Asn Glu 
    1055                 1060                 1065             


Thr Thr  Phe Leu Lys Lys Asp  Tyr Ala Ile Glu Asn  Ala Arg Thr 
    1070                 1075                 1080             


Ile Glu  
    1085 


<210>  2117
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2117

Met Glu Asn Leu Ser Lys Glu Gln Ile Val Glu Thr Gln Glu Gln Asn 
1               5                   10                  15      


Lys Arg Thr Trp Gly Asn Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn 
            20                  25                  30          


Met Ala Arg Leu Asn Ile Tyr Asn Val Ser Asn His Leu Ala Glu Lys 
        35                  40                  45              


Phe Gly Ile Thr Ala Ile Glu Asn Glu Glu Gln Ile Ser Asn Ser Phe 
    50                  55                  60                  


Leu Gly Asp Lys Glu Asn Lys Val Phe Lys Asn Lys Gln Asn His Ile 
65                  70                  75                  80  


Phe Ser Asn Leu Ile Arg Tyr Leu Pro Ile Val Lys Val Phe Asp Phe 
                85                  90                  95      


Glu Lys Leu Pro Glu Glu Glu Lys Ile Ser Leu Lys Asp Asn Phe Gly 
            100                 105                 110         


Lys Asp Phe Lys Glu Leu Ser Asp Thr Leu Lys Ile Ile Phe Ser Glu 
        115                 120                 125             


Ile Asn Glu Phe Arg Asn Asp Tyr Ser His Tyr Phe Ser Thr Glu Lys 
    130                 135                 140                 


Lys Asn Lys Arg Lys Thr Lys Val Ser Asp Lys Leu Lys Asp Phe Leu 
145                 150                 155                 160 


Asn Ile Asn Tyr Thr Arg Ala Ile Gln Tyr Thr Lys Asn Arg Phe Ile 
                165                 170                 175     


Asn Val Phe Ser Asp Asn Asp Phe Cys Leu Ala Glu Glu Ala Lys Leu 
            180                 185                 190         


Val Glu Asn Asp Asn Thr Ile Thr Gln Asp Gly Ile Val Phe Phe Thr 
        195                 200                 205             


Ser Met Phe Leu Asp Arg Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile 
    210                 215                 220                 


Lys Gly Leu Lys Gly Thr Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu 
225                 230                 235                 240 


Val Leu Met Ala Phe Cys Ile Asn Leu Pro His Asp Lys Phe Val Ser 
                245                 250                 255     


Glu Asn Thr Glu Gln Ala Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn 
            260                 265                 270         


Lys Cys Pro Lys Thr Leu Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln 
        275                 280                 285             


His Phe Leu Pro Lys Leu Glu Asp Glu Gln Ile Asp Asn Val Leu Glu 
    290                 295                 300                 


Asn Ser Val Pro Tyr Thr Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn 
305                 310                 315                 320 


Ile Thr Lys Lys Val Arg Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu 
                325                 330                 335     


Lys Phe Ile Asp Gln Lys Glu Leu Phe Lys Asn Trp Lys Phe Gln Ile 
            340                 345                 350         


Asp Leu Gly Lys Val Val Leu Asp Glu Tyr Thr Lys Thr Leu Gln Gly 
        355                 360                 365             


Lys Asp Glu Thr Arg Thr Val Val Glu Asn Ala Lys Ala Phe Gly Lys 
    370                 375                 380                 


Leu Gln His Leu Asn Asp Glu Glu Asn Val Leu Asn Lys Ile Asn Lys 
385                 390                 395                 400 


Ser Glu Ser Lys Thr His Phe Glu Gln Phe Ala Pro His Tyr Asn Phe 
                405                 410                 415     


Asp Asn Asn Lys Ile Gly Ile Ser Arg Lys Glu Asp Ser Ala Ile Phe 
            420                 425                 430         


Ile Ser Arg Asn Thr Asp Lys Lys Val Lys Phe Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Glu Ala Phe Leu Ser Ile His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Glu Asn Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Glu Ile Asn Asn Ser Lys Ile Leu Asn Lys Lys Phe Ile Glu Ser 
                485                 490                 495     


Ile Lys Ser Lys Leu Thr Asp Phe Asn Thr Phe Asn Lys Arg Ser Gln 
            500                 505                 510         


Gly Arg Lys Glu Lys Ser Ala Tyr Lys Lys Glu Ala Leu Lys Tyr Leu 
        515                 520                 525             


Leu Asp Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu Tyr Asn Leu 
    530                 535                 540                 


Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp Leu Asn Val 
545                 550                 555                 560 


Ala Asp Val Gln Glu Lys Thr Ala Ile Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Asp Arg Ile Lys Ala Met Lys Lys Gly Lys Ala 
            580                 585                 590         


Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp Ile Val Asp 
        595                 600                 605             


Met Ile Ile Gly Glu Glu Lys Lys Lys Lys Ile Thr Ser Phe Tyr Tyr 
    610                 615                 620                 


Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Lys Glu Lys Lys 
625                 630                 635                 640 


Glu Leu Phe Ile His Ile Cys Asn Asn Glu Leu Lys Leu Asn Glu Ser 
                645                 650                 655     


Asp Gly His Pro Phe Leu Lys Asn Ile Ile Leu Tyr Asp Tyr Arg Tyr 
            660                 665                 670         


Thr Ser Asp Leu Tyr Arg Arg Tyr Leu Glu Glu Lys Ala Asp Asn Arg 
        675                 680                 685             


Asn Asn Leu Asn Lys Asn Asp Thr Ser Trp Leu Ala Lys Asn Phe Tyr 
    690                 695                 700                 


Phe Ile Glu Lys Val Glu Val Phe Asp Lys Arg Leu Asn Arg Met Glu 
705                 710                 715                 720 


Phe Lys Pro Gln Thr Val Val Lys Ile Lys Asp Lys Ser Lys Ile Pro 
                725                 730                 735     


Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser Phe Asp Thr Trp 
            740                 745                 750         


Phe Glu Asn Ile Thr Lys Gly Lys Glu Thr Thr Asp Lys Lys Lys Pro 
        755                 760                 765             


Val Asp Leu Pro Thr Asn Leu Phe Asp Asn Tyr Leu Lys Glu Leu Leu 
    770                 775                 780                 


Ile Lys Asp Leu Ser Lys Asn Asn Ile Lys Phe Asn Pro Lys Thr Asn 
785                 790                 795                 800 


Tyr Asn Glu Leu Phe Lys Leu Trp Trp Lys Glu Cys Arg Lys Asp Lys 
                805                 810                 815     


Thr Gln Ser Phe Tyr Asn Ala Glu Arg Glu Tyr Ser Phe Glu Asp Lys 
            820                 825                 830         


Lys Leu Asn Phe Lys Ile Asn Thr Lys Ser Lys Phe Glu Asp Tyr Ile 
        835                 840                 845             


Asn Pro Glu Phe Ala Glu Lys Val Phe Lys Leu Lys Ser Ser Arg Arg 
    850                 855                 860                 


Glu Lys Glu Asn Ser Thr Gly Arg Lys Leu Pro Pro Leu Met Ile Lys 
865                 870                 875                 880 


Asp Leu Glu Lys Ser Met Ala Asn Lys Ile Gly Ser Ile Glu Lys Asp 
                885                 890                 895     


Ile Arg Ile Leu Gln Glu Asp Asp Cys Met Met Leu Leu Met Phe Glu 
            900                 905                 910         


Lys Leu Val Asp Asn Asn Leu Glu Leu Lys Leu Glu Asn Val Asp Thr 
        915                 920                 925             


Leu Met Asn Glu Ser Ile Glu Ile Lys Gln Ser Ile Leu Gly Lys Leu 
    930                 935                 940                 


Ser Phe Asp Asp Phe Gly Asp Asn Val Asn Lys Asn Asp Arg Ile Ile 
945                 950                 955                 960 


Ile Ser Lys Asn Ile Thr Glu Thr Arg Lys Arg Lys Glu Tyr Ser Val 
                965                 970                 975     


Leu Lys Lys Tyr Ile Phe Asp Arg Arg Leu Pro Glu Leu Phe Glu Tyr 
            980                 985                 990         


Phe Glu Thr Glu Asp Ile Thr Met  Glu Lys Ile Lys Leu  Glu Leu Gly 
        995                 1000                 1005             


Thr Tyr  Asn Lys Ala Lys Asp  Ile Val Phe Asp Leu  Ile Phe Asp 
    1010                 1015                 1020             


Leu Glu  Ser Ala Ile Ile Lys  Lys Asn Glu Asn Arg  Ile Lys Glu 
    1025                 1030                 1035             


Leu Asn  Lys Asp Lys Asn Gly  Asn Ile Gln Thr Gly  Asn Ile Gln 
    1040                 1045                 1050             


His Lys  Pro Tyr Leu Phe Trp  Leu Leu Glu Lys Asn  Leu Ile Thr 
    1055                 1060                 1065             


Glu Gln  Glu Phe Thr Phe Leu  Asn Met Val Arg Asn  Thr Phe Ser 
    1070                 1075                 1080             


His Asn  Gln Phe Pro Gln Lys  Lys Thr Met Glu Leu  Phe Ile Lys 
    1085                 1090                 1095             


Asn Trp  Asn Lys Asn Glu Tyr  Ala Lys Gln Ile Leu  Thr Val Tyr 
    1100                 1105                 1110             


Thr Glu  Lys Ile Asn Asn Leu  Ile Glu Lys Val Ile  Asp Ile 
    1115                 1120                 1125         


<210>  2118
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2118

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2119
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2119

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Thr 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2120
<211>  1152
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2120

Met Glu Asn His Thr Lys Gln Thr Thr Tyr Lys Tyr Asp Glu Ile Ala 
1               5                   10                  15      


Asp Lys His Tyr Phe Ala Gly Phe Phe Asn Leu Ala Trp Asn Asn Ile 
            20                  25                  30          


Glu Ile Val Phe Lys Val Phe Leu Lys Lys Phe Lys Leu Ile Glu Asp 
        35                  40                  45              


Lys Asp Lys Lys Ile Glu Val Asn Pro Leu Ser Phe Val Asp Asn Tyr 
    50                  55                  60                  


Phe Lys Asn Glu Leu Ala Leu Ser Asp Tyr Arg Asp Arg Ile Asp Phe 
65                  70                  75                  80  


Leu Lys Gln Tyr Phe Pro Val Val Gln Tyr Leu Glu Leu Leu Val Ser 
                85                  90                  95      


Lys Asn Asn Asp Leu Glu Lys Cys Ile Gly Glu Glu Lys Glu Asn Lys 
            100                 105                 110         


Arg Arg Glu Cys Phe Arg Ala Lys Phe Lys Ser Leu Ile Arg Thr Ile 
        115                 120                 125             


Asn Glu Leu Arg Asn Tyr Tyr Thr His His Tyr His Lys Pro Ile Ile 
    130                 135                 140                 


Val Asp Glu Ala Thr Phe Glu Leu Leu Asp Glu Leu Phe Leu Thr Val 
145                 150                 155                 160 


Val Lys Glu Val Lys Arg Tyr Lys Met Lys Gly Glu Pro Ile Arg His 
                165                 170                 175     


Leu Phe Lys Lys Glu Leu Asn Asn Glu Leu Thr Ala Leu Ile Lys Leu 
            180                 185                 190         


Lys Lys Ser Glu Leu Glu Thr Arg Arg Lys Glu Gly Lys Arg Val Asn 
        195                 200                 205             


Asn Asp Pro Val Ser Ile Glu Asn Ala Val Leu Asn Asp Ala Phe Ser 
    210                 215                 220                 


His Leu Leu Leu Gly Glu Lys Lys Val Lys Lys Phe Tyr Gln Ser Lys 
225                 230                 235                 240 


Ser Thr Ser Ser Asn Gln Gln Ser Thr Ile Asn Ile Ser Glu Ser Gly 
                245                 250                 255     


Leu Leu Phe Leu Leu Gly Met Phe Leu His Lys Lys Glu Ser Glu Arg 
            260                 265                 270         


Leu Arg Ser Asn Ile Gln Gly Phe Lys Ala Lys Val Val Arg Asp Pro 
        275                 280                 285             


Glu Lys Pro Ile Asp Phe Lys Asn Asn Ser Leu Lys Tyr Met Ala Thr 
    290                 295                 300                 


His Trp Val Phe Asn His Leu Ala Ala Lys Pro Ile Lys Glu Arg Leu 
305                 310                 315                 320 


Asn Thr Ala Phe Gln Lys Glu Thr Leu Leu Leu Gln Ile Ala Asp Glu 
                325                 330                 335     


Leu Ser Lys Val Pro Asp Glu Val Tyr Gln Thr Phe Ser Gln Glu Lys 
            340                 345                 350         


Lys Asn Glu Phe Leu Glu Asp Ile Asn Glu Tyr Phe Lys Thr Gly Asn 
        355                 360                 365             


Asp Ile Lys Ser Phe Glu Glu Ser Arg Val Val His Pro Val Ile Arg 
    370                 375                 380                 


Lys Arg Tyr Glu Asn Lys Phe Asn Tyr Phe Val Leu Arg Phe Leu Asp 
385                 390                 395                 400 


Glu Phe Ile Asp Phe Pro Thr Leu Arg Phe Gln Ile His Leu Gly Asn 
                405                 410                 415     


Tyr Val His Asp Gln Lys Glu Lys Pro Ile Ser Gln Gly Thr His Leu 
            420                 425                 430         


Ile Thr Gln Arg Ile Ile Lys Glu Lys Ile Asn Leu Phe Gly Lys Leu 
        435                 440                 445             


Ser Glu Val Thr Asn Asn Lys Thr Asp Phe Phe Gln Lys Leu Glu Val 
    450                 455                 460                 


Ala Gly Gly Glu Thr Asn Leu Glu Met Phe Pro Glu Pro Ser Tyr Asn 
465                 470                 475                 480 


Phe Val Gly Asn Asn Ile Pro Ile Tyr Leu Asn Leu Ala Lys Ser Lys 
                485                 490                 495     


Val Glu Gly Ala Lys Glu Leu Asn Ser His Leu Ile Arg Leu Asn Asn 
            500                 505                 510         


Glu Glu Lys Glu His Gln Lys Lys Arg Thr Gly Asn Lys Pro Asp Lys 
        515                 520                 525             


Thr Ile Gln Ile Ser Gly Ile Ser Tyr Gly Lys Pro Val Ala Leu Leu 
    530                 535                 540                 


Ser Leu Asn Glu Leu Pro Ala Leu Leu Tyr Glu Leu Leu Ile Asn Gly 
545                 550                 555                 560 


Lys Ser Gly Glu Glu Ile Glu Asn Ile Leu Val Glu Lys Leu Val Ala 
                565                 570                 575     


Arg Tyr Lys Thr Ile Asn Asn Phe Ser Pro Asp Asn Pro Leu Pro Thr 
            580                 585                 590         


Ser Gln Ile Ser Lys Lys Leu Arg Lys Ala Thr Ala Asn Glu Arg Ile 
        595                 600                 605             


Asp Ile Asp Lys Leu Ile Arg Ala Ile Asp Arg Glu Ile Ala Val Ser 
    610                 615                 620                 


Lys Glu Lys Ala Asn Leu Ile Ala Thr Lys Leu Arg Asp Trp Glu Asn 
625                 630                 635                 640 


Ala Lys Thr Asn Arg Lys Tyr Ala Phe Thr Lys Lys Glu Leu Gly Gln 
                645                 650                 655     


Glu Ala Thr Trp Leu Ala Asp Asp Ile Lys Arg Phe Met Pro Asn Lys 
            660                 665                 670         


Val Lys Glu Asn Trp Lys Gly Tyr Gln His Ser His Leu Gln Leu Leu 
        675                 680                 685             


Leu Ala Phe Tyr Glu Ser Arg Pro Asn Glu Ala Tyr Ser Phe Ile Gln 
    690                 695                 700                 


Glu Phe Trp Asn Leu Asp Asn Asp Thr Tyr Leu Phe Asn Arg Trp Leu 
705                 710                 715                 720 


Lys Thr Ser Phe Asn Glu Lys Ser Phe His Lys Phe Tyr Leu Lys Tyr 
                725                 730                 735     


Leu Glu Asn Arg Lys Lys Tyr Phe Glu Asn Ile Arg His Gln Ile Thr 
            740                 745                 750         


Ala Phe Lys Asn Gln Glu Lys Leu Leu Lys Lys Phe Ile Glu Gln Gln 
        755                 760                 765             


His Ile Trp Ser Val Phe Tyr Lys Arg Leu Tyr Ile Val Ser Pro Ile 
    770                 775                 780                 


Glu Glu Gln Lys Arg Gln Leu Leu Leu Lys Pro Leu Val Phe Thr Arg 
785                 790                 795                 800 


Gly Ile Phe Asp Pro Lys Pro Thr Tyr Ile Glu Gly Lys Glu Phe Glu 
                805                 810                 815     


Gly Asn Lys Asp Leu Phe Ala Asp Trp Tyr Gln Tyr Ile His Asp Lys 
            820                 825                 830         


Glu His Val Leu Gln Lys Phe Tyr Ser Trp Lys Arg Asp Tyr Lys Glu 
        835                 840                 845             


Leu Phe Glu Lys Phe Lys Ala Ser Asp Glu Phe Thr Asn Asn Lys Tyr 
    850                 855                 860                 


Gln Leu Ser Glu Lys Gln Gln Phe Glu Leu Phe Asn Arg Lys Trp Asp 
865                 870                 875                 880 


Lys Lys Ile Arg Lys Ile Ile Gly Gln Asp Leu Phe Leu Asn Leu Ile 
                885                 890                 895     


Ile Lys Arg Ile Ile Lys Glu Leu Tyr His Gln Asp Val Ala Leu Asn 
            900                 905                 910         


Leu Ala Asp Tyr Tyr Leu Thr Gln Glu Glu Arg Ile Glu Lys Glu Gln 
        915                 920                 925             


Arg Ala Lys Gln Gln Thr Asn Arg Leu Lys Gly Asp Lys Ser Glu Asn 
    930                 935                 940                 


Ile Ile Asn Asp Ser Phe Ile Trp Asn Met Thr Ile Ser Tyr Lys Thr 
945                 950                 955                 960 


Asp Tyr Ile Asn Glu Pro Ala Ile Lys Leu Lys Asp Ile Gly Lys Phe 
                965                 970                 975     


Ile Arg Phe Leu Asn Asp Glu Lys Val Glu Arg Ile Phe Ser Tyr Thr 
            980                 985                 990         


Pro Lys Lys Asn Asn Trp Arg Lys  His Glu Ile Glu Lys  Glu Leu Glu 
        995                 1000                 1005             


Met Tyr  Glu Lys Ile Arg Arg  Glu Glu Val Phe Lys  Met Ile Gln 
    1010                 1015                 1020             


Glu Leu  Glu Lys Lys Ile Leu  Glu Lys His Lys Phe  Asp Gly Ile 
    1025                 1030                 1035             


Asn His  Pro Asp Glu Phe Glu  Lys Ser Gly Asn Pro  Asn Phe Lys 
    1040                 1045                 1050             


Lys Tyr  Ile Thr Gln Gly Val  Leu Lys Lys Arg Gly  Ile Gln Asp 
    1055                 1060                 1065             


Val Val  Ile Glu Trp Ile Glu  Asn Leu Gly Glu Asn  Ser Tyr Glu 
    1070                 1075                 1080             


Asp Asn  Asp Thr Leu Glu Leu  Leu Val Gln Lys Asp  Glu Lys Val 
    1085                 1090                 1095             


Gln Asp  Ala Phe Leu Leu Ile  Tyr Leu Arg Asn Lys  Phe Ala His 
    1100                 1105                 1110             


Asn Gln  Leu Pro Thr Lys Glu  Ile Phe Asp Ile Ile  Val Ser Lys 
    1115                 1120                 1125             


Thr Asp  Thr Lys Ser Tyr Val  Ala Glu Thr Leu Leu  Asn Tyr Ile 
    1130                 1135                 1140             


Ser Ile  Thr Ser Arg Arg Ile  Leu Asn 
    1145                 1150         


<210>  2121
<211>  1193
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2121

Met Glu Ser Thr Val Asn Ala Lys Arg Ile Ser Tyr Asp Tyr Lys Asn 
1               5                   10                  15      


Gln Glu Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln Asn 
            20                  25                  30          


Asn Ile Glu Glu Thr Ile Glu Ala Leu Gly Ile Arg Asn Gln Val Phe 
        35                  40                  45              


Lys Lys Glu Asp Ser Asn Lys Lys Asn Lys Ser Arg Pro Ala Glu Ile 
    50                  55                  60                  


Ile Ala Lys Val Phe Gln Ile Asp Leu Lys Lys Arg Lys Thr Lys Asp 
65                  70                  75                  80  


Asp Gly Ser Gly Ile Thr Tyr Ala Gln Trp Glu Ser Asn Val Asn Phe 
                85                  90                  95      


Leu Lys Gln Tyr Leu Pro Ile Val Gln Phe Leu Asn Leu Pro Val Ser 
            100                 105                 110         


His Lys Lys Phe Asp His Leu Pro Lys Ala Lys Lys Glu Lys Ala Lys 
        115                 120                 125             


Arg Asp Tyr Phe Ile Gly Asn Phe Leu Leu Leu Ile Asp Ile Ile Gly 
    130                 135                 140                 


Ser Leu Arg His Tyr Tyr Thr His Tyr His His Lys Gln Ile Ser Ile 
145                 150                 155                 160 


Glu Pro Glu Leu Phe Thr Leu Leu Asp Glu Ile Phe Leu His Thr Cys 
                165                 170                 175     


Leu Val Val Lys Lys Arg Lys Met Lys Ser Glu Lys Thr Arg Glu Leu 
            180                 185                 190         


Leu Lys Arg Glu Leu Glu Arg Glu Val Asp Ile Leu Lys Lys Leu Lys 
        195                 200                 205             


Leu Ala Ala Leu Lys Lys Gln Lys Glu Asp Gly Val Arg Val Ser Leu 
    210                 215                 220                 


Asp Asp Glu His Val Glu Arg Ala Val Leu Asn Glu Ser Phe Asn Tyr 
225                 230                 235                 240 


Leu Leu Ala Lys Arg Asp Asn Val Tyr Lys Val Gln Pro Thr His Cys 
                245                 250                 255     


Ser Arg Gly Glu Asp Gly Thr Pro Phe Ser Arg Ser Gly Leu Val Phe 
            260                 265                 270         


Leu Val Ser Met Phe Leu Thr Lys Lys Gln Gly Glu Asp Phe Arg Ser 
        275                 280                 285             


Arg Ile Lys Gly Phe Lys Glu Lys Ile Val Lys Arg Glu Glu Asn Ala 
    290                 295                 300                 


Ile Ser Pro Thr Asn Asn Ser Leu Arg Phe Met Ala Thr His Trp Val 
305                 310                 315                 320 


Phe Ser Tyr Trp Ser Tyr Lys Gly Phe Lys Ala Lys Leu Asn Thr Thr 
                325                 330                 335     


Phe Ser Lys Glu Val Leu Glu Leu Lys Gly Ile Glu His Arg Leu Asn 
            340                 345                 350         


Thr Thr Val Ile Ser Lys Glu Ala Leu Leu Ala Gln Ile Val Asp Glu 
        355                 360                 365             


Leu Ser Lys Val Pro Asp Glu Val Tyr Glu Val Leu Ser Leu Asp Lys 
    370                 375                 380                 


Arg Asn Glu Phe Leu Glu Asp Val Asn Glu Tyr Ile Arg Glu Thr Arg 
385                 390                 395                 400 


Glu Val Glu Thr Leu Asp Lys Ser Ile Val Glu His Ser Val Ile Arg 
                405                 410                 415     


Lys Arg Tyr Glu Ser Lys Phe Gly Tyr Leu Ala Leu Arg Tyr Leu Asp 
            420                 425                 430         


Glu Phe Val Asp Phe Pro Ser Leu Arg Phe Gln Val Arg Leu Gly Asn 
        435                 440                 445             


Tyr Val His Asp Ser Arg Thr Lys Val Ile Glu Gly Thr Lys Leu Val 
    450                 455                 460                 


Thr Glu Arg Gln Ile Lys Glu Pro Ile Asn Val Phe Gly Lys Leu Ser 
465                 470                 475                 480 


Lys Val Lys Glu Leu Lys Thr Gln Phe Phe Leu Ser Ser Asp Asp Glu 
                485                 490                 495     


Glu Asn Ser Met Glu Ile Phe Pro Asn Pro Ser Tyr Cys Phe Val Glu 
            500                 505                 510         


Asn Asn Ile Pro Ile Ile Phe Ser Val Glu Gly Asn Val Lys Ala Asn 
        515                 520                 525             


Ser Ile Tyr Asn Lys Ile Lys Leu Lys Ile Arg Thr Gln Arg Asn Lys 
    530                 535                 540                 


Asp Glu Lys Arg Val Asp Arg Ser Gly Arg Lys Phe Pro Lys Ser Arg 
545                 550                 555                 560 


Ile Phe Ser Ile Val Asn Ser Lys Trp Asp Lys Ser Glu Ser Lys Lys 
                565                 570                 575     


Val Lys Leu Ala Glu Pro Met Ala Leu Leu Ser Phe Asn Glu Leu Pro 
            580                 585                 590         


Ser Leu Leu Tyr Glu Leu Leu His Lys Lys Lys Thr Pro Gln Ala Ile 
        595                 600                 605             


Glu Asp Ala Ile Val Glu Lys Tyr Val Glu Gln Phe Glu Ala Ile Glu 
    610                 615                 620                 


Asn Phe Asp Ser Gln Ser Thr Val Gln Lys Ser Arg Ile Pro Lys Lys 
625                 630                 635                 640 


Met Lys Lys Ser Asp Lys Ile Gly Lys Leu Asp Tyr Glu Lys Leu Val 
                645                 650                 655     


Lys Asp Ile Asp Arg Ser Leu Ala Glu Thr Lys Glu Lys Arg Lys Leu 
            660                 665                 670         


Leu Leu Gln Lys Gln Lys Asp Ala Lys Glu Asn Asn Lys Gln Thr Leu 
        675                 680                 685             


Ser Ser Ser Glu Leu Gly Gln Glu Ala Val Trp Leu Ser Asp Asp Ile 
    690                 695                 700                 


Lys Arg Leu Met Pro Arg Ser Ser Arg Lys Glu Trp Lys Gly Arg His 
705                 710                 715                 720 


His Ser His Leu Gln Tyr Thr Leu Ala Phe Tyr Asp Val Arg Lys Lys 
                725                 730                 735     


Glu Ala Leu Ala Leu Leu Glu Asn Phe Trp Asp Met Asp Lys Asp Pro 
            740                 745                 750         


Tyr Trp Gly Glu Lys Leu Lys Asn Glu Phe Asn Ala Asn Asn Thr Phe 
        755                 760                 765             


Glu Tyr Phe Tyr Phe Ser Tyr Leu Asn Leu Arg Glu Gly Ile Leu Ser 
    770                 775                 780                 


Thr Phe Leu Asp Gln Ile Glu Glu Tyr Lys Asp Gln Pro Gly Asn Leu 
785                 790                 795                 800 


Lys Lys Ala Leu Lys Asp Ile Gly Ile Val Phe Gln Met Arg Lys Tyr 
                805                 810                 815     


Arg Ile Lys Pro Leu Glu Asp Gln Lys Thr Ala Leu Leu Ala Lys Pro 
            820                 825                 830         


Ile Leu Leu Pro Arg Gly Ile Phe Asp Pro Lys Pro Thr Phe Ile Lys 
        835                 840                 845             


Lys Lys Arg Met Asp Glu Phe Pro Asp Glu Phe Ala Glu Trp Tyr Thr 
    850                 855                 860                 


Tyr Ala Asn Ala Pro Glu Arg Gln Phe Gln Arg Phe Tyr Ala Met Glu 
865                 870                 875                 880 


Arg Asp Tyr Gln Glu Leu Trp Lys Thr Glu Lys Asp Thr Asp Pro Asp 
                885                 890                 895     


Phe Lys Gln Asn Lys Lys Gly Ile Ser Glu Glu Gln Gln Ile Ala Leu 
            900                 905                 910         


Phe Lys Met Lys Gln Asp Leu Lys Ile Lys Lys Ile Lys Thr Gln Asp 
        915                 920                 925             


Leu Phe Leu Lys Leu Ile Ala Glu Gln Leu Tyr Leu Asp Val Phe Gly 
    930                 935                 940                 


His Lys Ala Thr Phe Ser Leu Ser Asp Met Tyr Gln Thr Lys Glu Glu 
945                 950                 955                 960 


Arg Arg Glu Ile Glu Arg Leu Ser Ala Lys Gln Ser Asn Arg Ala Gln 
                965                 970                 975     


Gly Asp Lys Ser Asp Asn Ile Val Ser Glu Asn Tyr Ile Trp Asn Lys 
            980                 985                 990         


Thr Val Gly Phe Lys Asp Gln Gln  Leu Glu Glu Pro Cys  Val Lys Leu 
        995                 1000                 1005             


Lys Asp  Ile Gly Lys Ile Arg  Arg Phe Val Asn Asn  Glu Lys Val 
    1010                 1015                 1020             


Gln Lys  Leu Phe Ala Tyr Asn  Leu Asp Arg Ile Trp  Thr Lys Arg 
    1025                 1030                 1035             


Glu Leu  Glu Asp Glu Leu Glu  Met Lys Pro Ser Ser  Tyr Glu Val 
    1040                 1045                 1050             


Ile Arg  Arg Glu Lys Leu Leu  Lys Glu Val Gln Asn  Leu Glu Lys 
    1055                 1060                 1065             


Tyr Ile  Leu Lys Gln Tyr Gly  Phe Asp Asn Glu Asn  His Pro Ser 
    1070                 1075                 1080             


Ile Phe  Glu Arg Asp Gly Asn  Pro Asn Phe Asn Glu  Tyr Val Val 
    1085                 1090                 1095             


Gln Gly  Ile Leu Lys Lys Lys  Asn Leu Val Ser Glu  Asp Glu Cys 
    1100                 1105                 1110             


Asp Trp  Phe Ser Lys Gln Lys  Ile Glu Lys Ile Lys  Leu Asp Thr 
    1115                 1120                 1125             


Leu Arg  Gln Lys Ser Asp Ile  Leu Ile Lys Ala Tyr  Ile Leu Ile 
    1130                 1135                 1140             


Leu Ile  Arg Asn Thr Phe Ala  His Asn Gln Leu Pro  Asp Lys Glu 
    1145                 1150                 1155             


Cys Val  Asp Leu Met Gln Glu  Phe Cys Gln Lys Asp  Pro Gly Ile 
    1160                 1165                 1170             


Ser Tyr  Ser Glu Tyr Phe Leu  Tyr Val Phe Gln Gln  Ile Ala Lys 
    1175                 1180                 1185             


Glu Phe  Thr Asn Ala 
    1190             


<210>  2122
<211>  1147
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2122

Met Ser Gly Asn Tyr Val Asn Asp Arg Ile Gly Ser Val Arg Arg Ala 
1               5                   10                  15      


Ser Gln Gly Ala Gly Gly Gly Phe Lys Lys Pro Arg Thr Tyr Leu Ser 
            20                  25                  30          


Gly Asp Phe Ala Arg Asp Met Lys Ala Leu Arg Ile Lys Gly Ser Val 
        35                  40                  45              


Arg Asp Ala Arg Thr Arg Arg Asp Leu Glu Lys Asp Glu Thr Pro Ala 
    50                  55                  60                  


Phe Ile Ala Tyr Leu Thr Leu Ala Leu Glu Asn Leu Gly Asn Ile Leu 
65                  70                  75                  80  


Gly Lys Val Asp Leu Ser Gly Phe Met Arg Pro Glu Ala Val Thr Glu 
                85                  90                  95      


Ala Leu Asp Glu Ser Gly Arg Leu Phe Glu Leu Ala Ser Phe Leu Trp 
            100                 105                 110         


Met Phe Arg Glu Gly Glu Pro Gln Phe Asn Tyr Gly Arg Val Arg Lys 
        115                 120                 125             


Pro Gly Glu Glu Arg Asp Tyr Glu Lys Phe Ala Lys Ala Ile Val Leu 
    130                 135                 140                 


Lys Leu Trp Glu Leu Arg Asn Met Phe Val His Ser Thr Gln Glu Arg 
145                 150                 155                 160 


Ala Ala Thr Val Leu Val Val Asp Pro Gly Phe Tyr Arg Phe Val Glu 
                165                 170                 175     


Gly Glu Leu Tyr Ser Glu Ala Arg Glu Asn Ala Leu Gly Pro Gly Arg 
            180                 185                 190         


Lys Ser Glu Lys Ile Phe Lys Leu Lys Leu Phe Thr Pro His Asn Glu 
        195                 200                 205             


Ser Asn Thr Gln Tyr Glu Phe Thr Arg Lys Gly Leu Ile Tyr Leu Ile 
    210                 215                 220                 


Cys Leu Ala Leu Tyr Arg His Asp Ala Asn Glu Phe Ile Gln Arg Phe 
225                 230                 235                 240 


Pro Asp Leu Gln Leu Pro Pro Arg Asp Trp Glu Val Glu Gly Gly Tyr 
                245                 250                 255     


Lys Pro Glu Lys Thr Glu Gln Glu Leu Val Glu Leu Arg Lys Lys Gly 
            260                 265                 270         


Gly Ser Val Lys Ala Ile Leu Asp Ala Phe Thr Tyr Phe Ser Met Arg 
        275                 280                 285             


Ala Ser Arg Thr Asp Ile Asp Val Ala Asp Ala Asp Tyr Leu Asn Phe 
    290                 295                 300                 


Ala Asn Ile Leu Leu Tyr Leu Asn Lys Val Pro Gly Pro Ala Tyr Asp 
305                 310                 315                 320 


Tyr Leu Ala Leu Gln Lys Glu Ala Asp Arg Leu Val Ala Glu Glu Lys 
                325                 330                 335     


Asp Ser Thr Glu Asn Met Glu Asn Lys Arg Phe Lys Tyr Val Leu Gln 
            340                 345                 350         


Ala Arg Lys Lys Asp Arg Phe Leu Thr Leu Ala Leu Ala Tyr Leu Glu 
        355                 360                 365             


Asp Phe Asn Lys Leu Ser Cys Leu Lys Phe Lys Arg Leu Asp Ile Thr 
    370                 375                 380                 


Val Arg Pro Glu Arg Lys Arg Tyr Leu Phe Gly Arg Ile Pro Glu Gly 
385                 390                 395                 400 


Ala Lys Asn Glu Phe Gly Asp Glu Ile Gln Asp Ala Asn Gly Met Asp 
                405                 410                 415     


Arg His Tyr Ala Ile Val Asn Gly Asn Ala Gln Phe Glu Phe Val Pro 
            420                 425                 430         


Ala Glu His Tyr Gly Pro Val Arg Ile Thr Arg Leu Arg Gly Ala Leu 
        435                 440                 445             


Gly Glu Asp Glu Ile Met Arg Leu Leu Leu Val Ile His Asp Cys Glu 
    450                 455                 460                 


Val Arg Arg Ala Asp Pro Asn Arg Val Leu Ala Asp Tyr Leu Thr Ala 
465                 470                 475                 480 


Tyr His Arg Ile Leu Glu Arg Met Leu Asn Ala Gln Asp Leu Ala Glu 
                485                 490                 495     


Leu Ser Leu Glu Asp Ala Gln Tyr Arg Ala Asp Phe Lys Thr Val Ser 
            500                 505                 510         


Gly Lys Asp Asp Ala Ala Leu Ala Pro Ala Val Phe Val Glu Gln Met 
        515                 520                 525             


Lys Pro Phe Phe Ser Ala Ser Val Thr Arg Tyr Phe Val Asn Gln Asp 
    530                 535                 540                 


Leu Arg Pro Asp Thr Ala Leu Leu Gln Lys Lys Leu Gly Ala His Leu 
545                 550                 555                 560 


Ala Ala Arg Arg Asp Arg Ala Gln Asp Thr Leu Val Arg Leu Asp His 
                565                 570                 575     


Leu Ser Glu Trp Leu Ala Leu Asp Lys Glu Ala Arg Val Ala Ala Gly 
            580                 585                 590         


Arg Pro Leu Cys Lys Val Gly Glu Leu Arg Phe Pro Pro Arg Thr Cys 
        595                 600                 605             


Arg Phe Asn Asp Ala Gln Leu Val Gly Met Val Leu Asp Phe Leu Asn 
    610                 615                 620                 


Phe Tyr Leu Ala Lys Glu Glu Lys Tyr Arg Gln Leu Pro Arg Gly Met 
625                 630                 635                 640 


Arg His Arg Gly Met Val Asp Tyr Glu Phe Gln Leu Leu His Thr Asp 
                645                 650                 655     


Ile Gly Arg Phe Gly Ile Asp Pro Gln Arg Leu Trp Arg Ser Leu Glu 
            660                 665                 670         


Lys Arg Glu Ser Leu Asn Ala Glu Gly Gly Pro Leu Glu Ala Leu Arg 
        675                 680                 685             


Ser Arg Glu Arg Glu Leu Phe Arg Ala Glu Glu Arg Arg Cys Lys Gly 
    690                 695                 700                 


Arg Leu Asp Arg Asn Gly Arg Pro Leu Arg Val Gly His Thr Leu Thr 
705                 710                 715                 720 


Met Leu Ala Tyr Ala Ala Thr Glu Leu Leu Ala Glu Gly Cys Glu Asp 
                725                 730                 735     


Ala Arg Gln Thr Trp Thr Gly Pro Leu Ser Asp Glu Asp Arg Glu Leu 
            740                 745                 750         


Leu Pro Tyr Val Ala Pro Met Tyr Gly Val Lys Ala Gly Gln Pro Leu 
        755                 760                 765             


Asp Arg Glu Ala Leu Val Arg Thr Val Leu Gly Ile Asp Leu Ala Ser 
    770                 775                 780                 


Trp Ser His Ala Tyr Asp Tyr Ala Ser Gly Lys Asn Phe Asp Gly Arg 
785                 790                 795                 800 


Gly Leu Glu Ser Ala Lys Glu Leu Ile Ala Ala Gln Ile Pro Met Pro 
                805                 810                 815     


Asn Asp Phe Ala Arg Arg Cys Val Thr Gln Pro Ala Glu Gly Val Phe 
            820                 825                 830         


Gln Phe Asn Pro Ala Phe Arg Ala Phe Lys Pro Tyr Gly Glu Met Ser 
        835                 840                 845             


Leu Arg Asp Tyr Tyr Asp Val Lys Pro Leu Ile Ala Ser Val Gln Lys 
    850                 855                 860                 


Leu Asp Ala Ala Thr Ala Leu Leu Ala Arg Val Glu Asp Ser His Ala 
865                 870                 875                 880 


Arg Ala Asn Ala Leu Ile Asp Pro Thr Leu Pro Gly Ile Glu Ser Arg 
                885                 890                 895     


Val Arg Pro Pro Gln Glu Glu Gly Asp Glu Arg Asn Arg Thr Glu Phe 
            900                 905                 910         


Ser Tyr Gly Lys Ser Ala Pro Gly Pro Arg Glu Phe Ser Arg Ala Val 
        915                 920                 925             


Val Asn Lys Ala Ile Gln Ser Ile Gln Arg Val Glu Arg Gln Asp Lys 
    930                 935                 940                 


Val Leu Leu Ala Cys Ala Lys Asp Tyr Trp Glu Arg Tyr Met Lys Ser 
945                 950                 955                 960 


Glu Val Met Ser Ser Ala Arg Ser Lys Val Leu Lys Phe Asp Phe Ala 
                965                 970                 975     


Gly Ala Lys Asp Ile Arg Glu Phe Phe Thr Leu Asp Leu Val Asp Glu 
            980                 985                 990         


Val Lys Gly Val Lys Val Arg Met  Met Pro Asn Asp Phe  Ala Arg Pro 
        995                 1000                 1005             


Ala Tyr  Ser Ala Val Thr Glu  His Ile Gln Glu Leu  Ala Gln Arg 
    1010                 1015                 1020             


Ile Ser  Val Pro Ala Asp Gly  Val Tyr Ala Phe Tyr  Asp Leu Trp 
    1025                 1030                 1035             


Leu Ala  Leu Arg Asp Leu Gln  Arg Arg Glu Asn Thr  Ala Arg Leu 
    1040                 1045                 1050             


Asp Leu  Leu Ala Ala Asp Val  Lys Phe Asp Ala Leu  Ile Gly Ala 
    1055                 1060                 1065             


Pro Gln  Leu Pro Lys Glu Met  Ser Ala Ala Glu Lys  Ser Glu Gln 
    1070                 1075                 1080             


Leu Phe  Leu His Ala Gln Lys  Ala Leu Arg Gly Ile  Ser Lys Asp 
    1085                 1090                 1095             


Pro Leu  Thr Arg Ala Glu Phe  Asp Leu Ile Leu Ala  Leu Ser Pro 
    1100                 1105                 1110             


Arg Leu  Arg His Pro Ser Gly  Arg Gly Gln Thr Leu  Leu Gly Gln 
    1115                 1120                 1125             


Asp Leu  Glu Ala Ala Arg Arg  Ile Tyr Arg Arg Phe  Gly Cys Leu 
    1130                 1135                 1140             


Thr Pro  Met Lys 
    1145         


<210>  2123
<211>  1217
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2123

Met Tyr Asn Lys Pro Asn Gly Ser Pro Glu Pro Phe Asp Leu Phe Thr 
1               5                   10                  15      


Gly Gly Lys Leu Pro Glu Leu Ala Ile Ala Phe Asn Leu Ala Tyr Asp 
            20                  25                  30          


Asn Ile Glu Lys Tyr Ile Arg Thr Ile Gln Ser Phe Glu Glu Pro Leu 
        35                  40                  45              


Asn Asn Ile Asp Lys Leu Lys Asp Glu Val Phe Val Tyr Leu Arg His 
    50                  55                  60                  


Tyr Ile Trp Lys Gly Asn Thr Glu Asn Lys Asn Ser Ser Gly Tyr Glu 
65                  70                  75                  80  


Leu Asp Pro Lys Glu Lys Ala Ile Ile Lys Lys Leu Leu Thr Lys Leu 
                85                  90                  95      


Lys Gln Leu Arg Asn Phe His Ser His Val Trp His Asp Asn Ser Met 
            100                 105                 110         


Met His Phe Asp Asn Glu Leu Val His Phe Ile Gln Asp Lys His Glu 
        115                 120                 125             


Val Ala Cys Asp Lys Leu Leu Glu Glu Lys Asn Ala Asp Ala Thr Leu 
    130                 135                 140                 


Tyr Leu Lys Gln Leu Lys Glu Tyr Pro Leu Phe Lys Asp Gly Lys Tyr 
145                 150                 155                 160 


Ile Thr Gln Asp Gly Arg Ile Phe Phe Leu Ser Leu Phe Leu Asn Lys 
                165                 170                 175     


Gly Glu Met Gln Ser Leu Leu Gln Gly Leu Lys Gly Ser Lys Arg Thr 
            180                 185                 190         


Asn Met Pro Ala Tyr Gln Phe Lys His Lys Val Tyr Thr Phe Tyr Cys 
        195                 200                 205             


His Arg Glu Gly Ser Ser Trp Asp Asn Thr Gly Val Asp Asn Lys Ala 
    210                 215                 220                 


Leu Gln Gln Arg Gly Asp Glu Glu Gln Lys Arg Ile Leu Tyr Gly Arg 
225                 230                 235                 240 


Gln Ala Asn Arg Ile Phe Ser Tyr Leu Lys Asp Ile Pro Ala Phe Thr 
                245                 250                 255     


Lys Glu Glu Ala Leu Pro Leu Val Leu Ser Ser Gly Lys Trp Val His 
            260                 265                 270         


Asp Met Asp Ser Leu Leu Leu Phe Ile Arg Glu Lys Asn Ile Leu Pro 
        275                 280                 285             


Gly Phe Ile Phe Phe Lys Met Glu Lys Glu Pro Asp Asp Asp Ile Thr 
    290                 295                 300                 


Gly Glu Lys Glu Leu Asn Glu Glu Lys Lys Ala Leu Glu Thr Lys Glu 
305                 310                 315                 320 


Arg Glu Gly Tyr Arg Tyr Phe Met Met Pro Glu Asn Asp Lys Tyr Asp 
                325                 330                 335     


Phe Glu Ile Ser Tyr Pro Ala Leu Lys His Ile Ala Thr Asp Ile Phe 
            340                 345                 350         


Leu Asp Ala Asn Asp Ala Glu Glu Val Glu Asn Ser Ser Leu Gln His 
        355                 360                 365             


Phe Asn Gly Val Leu Lys Asp Cys Ile Tyr Met Arg Asn His Ile Tyr 
    370                 375                 380                 


Asn Lys Leu Lys Ala Glu Gly Gly Lys Pro Ile His Pro Glu Asn Phe 
385                 390                 395                 400 


Val Leu Arg Lys Glu Tyr Asn Ser Val Tyr Ile Asn Tyr His Glu His 
                405                 410                 415     


Glu Gly Ser Ile Gln Glu Arg Tyr Tyr Thr Gly Asn Glu Trp Arg His 
            420                 425                 430         


Ile Pro Ile Ser Pro Thr Pro Lys Ile Glu Lys Leu Leu Ile Glu Trp 
        435                 440                 445             


His Val Ala Phe Thr Gln Gly Lys Asn Asp Lys Pro Asn Lys Gly Glu 
    450                 455                 460                 


Val Thr Lys Arg Val Lys Leu Leu Asn Lys Ile Arg Pro Lys Asn Glu 
465                 470                 475                 480 


Pro Phe Asp Thr Ser Ile Tyr Glu Gly Leu Leu Lys Thr Gly Lys Lys 
                485                 490                 495     


Lys Ile Ile Pro Asn Thr Glu Thr Glu Pro Leu Leu Phe His Leu Gly 
            500                 505                 510         


Tyr Tyr Tyr Arg Glu Gln Asp Thr Lys Lys Arg Lys Glu Asp Asn Phe 
        515                 520                 525             


Leu Glu Trp Gly Val Arg Tyr Leu Met Asp Met Arg Leu Val Pro Asp 
    530                 535                 540                 


Trp Tyr Phe Glu Leu Glu Gln Leu Lys Tyr Glu Gln Lys Ser Gly Glu 
545                 550                 555                 560 


Pro Glu Ser Pro Tyr Lys Leu Lys Lys Val Thr Ser Trp Asp Lys Asn 
                565                 570                 575     


Ile Pro Asp Asn Phe Arg Leu Arg Ile Thr Asp Asn Gln Val Asn Ile 
            580                 585                 590         


Gly Ile Ala Leu Glu Gly Lys Thr Tyr Arg Leu Arg Ile Gly Glu Lys 
        595                 600                 605             


Ile Met Lys Tyr Leu Leu Cys Trp His Phe Arg Glu Asn Lys Lys Glu 
    610                 615                 620                 


Asn Lys Ser Ile Asn Gly Phe Leu Leu Asn Ile Thr Lys Asp Leu Ala 
625                 630                 635                 640 


Ser Ile His Asn Ser Gln Ser Lys Val Asn Leu Ala Ser Leu Gln Leu 
                645                 650                 655     


Leu Glu Gly Phe Ala Val Pro Glu Leu Leu Tyr Lys Thr Lys Val Val 
            660                 665                 670         


Glu Glu Asn Glu Lys Gly Lys Lys Ala Asp Leu Tyr Lys Glu Glu Val 
        675                 680                 685             


Leu Lys Phe Phe Thr Glu Lys Trp Glu Trp Ala Asp Lys Asn Ile Lys 
    690                 695                 700                 


Asn Ile Lys Gln Leu Asn Arg Ser Glu Lys Asn Ala Val Leu Leu Asp 
705                 710                 715                 720 


Ala Tyr Arg Leu Phe Asp Phe Asn Glu Thr Glu Gly Gln Lys Phe Leu 
                725                 730                 735     


Arg Lys Asn Glu Tyr Glu Gln Met Ser Ile Cys His Tyr Met Leu Asn 
            740                 745                 750         


Gln Glu Lys Trp Lys Val Lys Gly Leu Ile Glu Arg Thr Phe Lys Leu 
        755                 760                 765             


Lys Arg Arg Leu Pro Gln Glu Ile Ile Asp Ile Leu Tyr Ser Val Ile 
    770                 775                 780                 


Asp Thr Glu Arg Gln Asn Leu Asp Asp Leu Leu Ile Leu Val Leu His 
785                 790                 795                 800 


Asn Arg Lys Lys Phe Leu Lys Asn Lys Ile Asp Leu Leu Lys Leu Pro 
                805                 810                 815     


Gly Ile Lys Asn Arg Gln Ile Lys Asn Asp Ile Ala Gly Phe Met Asp 
            820                 825                 830         


Ile Tyr Leu Asn Asp Ala Asn Leu Thr Thr Glu Glu Leu Gly Ile Arg 
        835                 840                 845             


Asn Lys Ala Arg Asn Lys Thr Leu Val Asn Leu Pro Phe Ala Val His 
    850                 855                 860                 


Pro Ala Leu Thr Leu Lys Tyr Phe Tyr Pro Gln Gln Phe Ala Ala Gln 
865                 870                 875                 880 


Gly Phe Arg Lys Glu Gly Gly Ala Tyr Thr Asn Leu Phe Tyr Lys Leu 
                885                 890                 895     


Arg Gln Asp Ala Arg Leu Ser Thr Met Leu Pro Asp Glu Ile Leu Arg 
            900                 905                 910         


Glu Lys Pro Val Thr Lys Ile Phe Glu Asp Tyr Ile Lys Gln Phe Pro 
        915                 920                 925             


Gln Asp Val Leu Leu Glu Ser Phe Thr Lys Lys Trp Thr Gly Thr Val 
    930                 935                 940                 


Asn Asp Ile Lys Thr Lys Asp Ile Leu Leu Leu Leu Val Ala Glu Val 
945                 950                 955                 960 


Tyr Leu Glu Lys Tyr Asp Ala His Thr Ala Thr Glu Phe Lys Lys Ile 
                965                 970                 975     


Lys Asn Leu Lys Lys Leu Gln Leu Asp Glu Leu Phe Lys Ala Glu Val 
            980                 985                 990         


Pro Val Thr Leu Lys Leu Asp Gln  Gln Leu Lys Lys Glu  Leu Glu Lys 
        995                 1000                 1005             


Glu Tyr  Lys Lys Ala Val Pro  Glu Ile Asn Leu Leu  Leu Arg Met 
    1010                 1015                 1020             


His Gln  Leu Asp Asp Tyr Phe  Phe Arg Ser Gln Lys  Glu Thr Leu 
    1025                 1030                 1035             


Ala Lys  Leu Ala Ile Phe Tyr  Ile Asn Trp Arg Asn  Glu Glu Leu 
    1040                 1045                 1050             


Lys Leu  Tyr Ala Gly Lys Thr  Asp Ile Met Asp Lys  Ile Lys Ala 
    1055                 1060                 1065             


Trp Pro  Asp Gly Ser Ala Ala  Lys Pro Leu Thr Met  Gly Gln Leu 
    1070                 1075                 1080             


Val Glu  Ala Arg Arg Val Asn  Ala Gly Tyr Ala Ala  Glu Leu Val 
    1085                 1090                 1095             


Gly Tyr  Ile Phe Asp Tyr Glu  Lys Gly Leu Leu Asn  Gly His Val 
    1100                 1105                 1110             


Asn Lys  Pro Asn Ser Ala Gln  Lys Gln Lys Met Leu  Thr Asp Tyr 
    1115                 1120                 1125             


Cys Leu  Thr Asn Gly Leu Leu  Ala Tyr Ile Asp Phe  Asn Ile Ile 
    1130                 1135                 1140             


Leu Asp  Trp Asp Lys Ile Thr  Asp Thr Glu Ile Lys  Lys Gln Ile 
    1145                 1150                 1155             


Lys Gly  Leu Arg Ile Asn Cys  Leu His Ser Leu Ile  Pro Leu Asn 
    1160                 1165                 1170             


Gly Ser  Tyr Arg Gln Gln Thr  Met Pro Gly Thr Pro  Val Ala Glu 
    1175                 1180                 1185             


Ala Leu  His Val His Thr Arg  Leu Gly Asn Asp Arg  Thr Ala Pro 
    1190                 1195                 1200             


Asn Ile  Tyr Glu Gln Asp Asp  Lys Asn Glu Thr Glu  Glu Ala 
    1205                 1210                 1215         


<210>  2124
<211>  1077
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2124

Met Ala Thr Phe Arg Phe Gln Asn Lys Tyr Val Cys Gly Ala Tyr Tyr 
1               5                   10                  15      


Asn Met Ala Gln Asn Asn Phe Arg Leu Ala Ile Leu His Val Leu Ser 
            20                  25                  30          


Arg Ile Gly Ile Asn Arg Lys Asp Glu Glu Arg Ala Ile Pro Glu Leu 
        35                  40                  45              


Leu Asp Thr Ile Tyr Gly Phe Leu Thr Gly Asp Thr Glu His Phe Asn 
    50                  55                  60                  


Asp Thr Gln Ile Leu Gln Lys Lys Val Leu Thr Leu Arg Tyr Asp Gln 
65                  70                  75                  80  


Gln Val Lys Leu Arg Glu Leu Leu Phe Arg Gln Phe Pro Ile Leu Lys 
                85                  90                  95      


Pro Ile Ile Ala Ser Glu Thr His Lys Ser Leu Gln Glu Gln Lys Glu 
            100                 105                 110         


Lys Leu Ser Glu Met Glu Glu Tyr Ile His Glu Phe Glu Lys Gln Leu 
        115                 120                 125             


Lys Arg Leu Tyr Arg Ser Lys Lys Gly Lys Ala Ser Gln Glu Gln Lys 
    130                 135                 140                 


Glu Ile Asn Glu Gln Ile Lys Gln Leu Lys Thr Lys Lys Ser Lys Tyr 
145                 150                 155                 160 


Leu Asp Glu Tyr Asp Thr Leu Leu Phe Ser Lys Ser His Asp Ala Asp 
                165                 170                 175     


Leu Gln Leu Cys Leu Lys Ile Leu Lys Thr Met Ala Trp Cys Leu Tyr 
            180                 185                 190         


Asp Leu Arg Asp Phe Tyr Thr His Tyr Asp Pro Tyr Asn Thr Pro Glu 
        195                 200                 205             


Ser Leu Lys Val Lys Tyr Leu Arg Gln Val Thr Val Ala Asn Trp Leu 
    210                 215                 220                 


Ser Gln Val Phe Ala Ala Ser Arg Thr Ile Asp Lys Glu Arg Asn Ser 
225                 230                 235                 240 


Ile Thr Thr Glu Glu Met Asn Phe Leu Asn Glu Ala Lys Lys Gln Gly 
                245                 250                 255     


Asp Asp Lys Lys Trp Arg Glu Asp Pro Asp Tyr Tyr Phe Ala Ile Lys 
            260                 265                 270         


Gly Gln Asn Leu Leu Ser Ser Ser Phe Ile Asp Ala Asp Ser Pro Val 
        275                 280                 285             


Tyr Asn Asp Tyr Leu Asp Glu Leu Tyr Gln Lys Tyr Arg Lys Lys Arg 
    290                 295                 300                 


Leu Ala Trp Met Lys Glu Gln Arg Asp Glu Ala Leu Glu Arg Asp Asp 
305                 310                 315                 320 


Glu Glu Glu Tyr Gly Phe Trp Val Val Glu Met Glu Lys Leu Asp Asn 
                325                 330                 335     


Pro Glu Arg Ile Ala Lys Ile Lys Ser Lys Ile Cys Pro Leu Ala Leu 
            340                 345                 350         


Ser Asp Phe Gly Val Leu Tyr Phe Cys Ala Thr Phe Leu Pro Arg Asn 
        355                 360                 365             


Tyr Thr Leu Leu Met Ala Asp His Ala Glu Leu Met Lys Tyr Ser Pro 
    370                 375                 380                 


Tyr Ser Met Thr Ala Glu Glu Leu Glu Ala Arg Arg Asn Ala Cys Lys 
385                 390                 395                 400 


Thr Asp Glu Glu Arg Glu Lys Ile Asp Gln Thr Asp Thr Pro Arg Asn 
                405                 410                 415     


Asn Ile Leu Arg Glu Met Leu Cys Ile Tyr Arg Val Arg Leu Pro Lys 
            420                 425                 430         


Gly Lys Arg Leu Asp Lys Lys Asp Thr Lys Gly Leu Leu Thr Leu Asp 
        435                 440                 445             


Ile Leu Asn Glu Leu Arg Lys Cys Pro Lys Glu Val Tyr Glu Gln Leu 
    450                 455                 460                 


Ser Lys Glu Gly Lys Asp Phe Phe Ile Ser Arg Val Ser Ser Ala Ser 
465                 470                 475                 480 


His Asn Ala Pro Asp Ile Val Lys Arg Ile Arg Phe Gly Asp Arg Phe 
                485                 490                 495     


Pro Tyr Leu Ala Leu Arg Ala Ile Asp Glu Ser Asp Val Phe Lys Arg 
            500                 505                 510         


Ile Arg Phe Gln Val Arg Leu Gly Ser Tyr Arg Phe Tyr Phe Tyr Asn 
        515                 520                 525             


Lys Thr Cys Ile Asp Gly Ser Thr Gln Leu Arg Arg Trp Gln Lys Glu 
    530                 535                 540                 


Ile Asn Gly Phe Gly Arg Leu Gln Asp Met Glu Ala Leu Arg Lys Ser 
545                 550                 555                 560 


Leu Trp Lys Asp Leu Leu Gln Lys Lys Glu Tyr Asp Ser Val Gln Leu 
                565                 570                 575     


Glu Asp Lys Ser Ser Tyr Leu Asp Leu Gln Gln Phe Lys Ala Asp Ala 
            580                 585                 590         


Pro Asp Ser Val Pro Tyr Ile Thr Asp Ser Gln Ala Gln Tyr Asn Ile 
        595                 600                 605             


His Asn Asn Arg Ile Gly Leu Ile Trp Asn Gly Asp Glu Cys Arg Leu 
    610                 615                 620                 


Leu Arg Asn Ile Lys Asp Ala Asp Val Leu Arg Glu Tyr Val Tyr Phe 
625                 630                 635                 640 


Pro Asp Leu Lys Asp Asn Asp Gly Asn Pro Lys Lys Ser Gly Lys Asp 
                645                 650                 655     


Ile Glu Gln Pro Ser Pro Leu Cys Ser Leu Ser Thr Tyr Glu Leu Pro 
            660                 665                 670         


Ala Leu Leu Phe Tyr His Phe Leu Tyr Asn Thr Pro Glu Ala Gln Val 
        675                 680                 685             


His Lys Glu Arg Leu Glu Lys Pro Glu Gln Val Ile Ile Lys Lys Tyr 
    690                 695                 700                 


Glu Ala Leu Arg Ala Phe Phe Leu Glu Leu Arg Ser His Pro Glu Gln 
705                 710                 715                 720 


Ile Val Lys Thr Asp Leu Gln Ala Thr Leu Thr Arg Phe Gly Leu Lys 
                725                 730                 735     


Cys Ser Glu Ile Pro Gln Arg Ile Ile Asp Cys Ile Gln Gly Cys Gln 
            740                 745                 750         


Gln Lys Gln Lys Glu Thr Glu Ser Ser Val Thr Tyr Leu Pro Asp Leu 
        755                 760                 765             


Leu Gln Leu Pro Met Glu Asp Ile Arg Gln Lys Val Gln Glu Lys Gly 
    770                 775                 780                 


Met Glu Arg Tyr Lys Asp Leu Pro Thr Lys Phe Arg Lys Gln Ile Ser 
785                 790                 795                 800 


His Glu Gln Ile Val Thr Ser Gly Leu Glu Thr Leu Leu Lys Pro Leu 
                805                 810                 815     


Gly Ile Ser Val Glu Ser Leu Pro Ala Lys Val Met Glu Ala Leu Leu 
            820                 825                 830         


Ser Thr Gln Ile Gln Glu Asp Val Ala Pro Ala Glu Asp Thr Ser Thr 
        835                 840                 845             


Glu Lys Pro Phe Asn Ile Met Phe Val Arg Ser Val Val Tyr Lys Leu 
    850                 855                 860                 


His Glu Arg Leu Gln Asp Val Ser Glu Arg His Gln Ser Phe Val Glu 
865                 870                 875                 880 


Ser Ile His His Val Gly Ser Lys Asp Asn Lys Phe Ala Lys His Gly 
                885                 890                 895     


Tyr Met Asp Val Arg His Gly Lys Leu Ala Glu Tyr Leu Ala Gly Ser 
            900                 905                 910         


Phe Leu Lys Trp Gln Pro Thr Ile Ser Asn Gly Ser Asp Lys Leu Thr 
        915                 920                 925             


Gly Leu Asn Tyr Asn Val Leu Lys Ser Phe Leu Ser Thr Tyr Gly Ile 
    930                 935                 940                 


Ala Thr Asp Ile Asp Asp Leu Thr Ala Val Leu His Glu Ala Lys Leu 
945                 950                 955                 960 


Ile His Leu Gly Lys Glu Glu Thr Pro Ile Pro His Pro Phe Leu Gln 
                965                 970                 975     


Lys Val Ile Asp Lys Glu Pro Gly Asn Leu Glu Lys Leu Phe His Leu 
            980                 985                 990         


Tyr Ile Ile Gln Glu Lys Glu Tyr  Leu Ser Asp Leu Leu  Ile Asp Tyr 
        995                 1000                 1005             


Leu Leu  Gln Ile Ser Thr Ala  Ile Gly Thr Glu Gly  Gln Asp Ala 
    1010                 1015                 1020             


Asp Ile  Leu Glu Glu Ala Tyr  Thr Cys Asn Gly Glu  Lys Leu Ile 
    1025                 1030                 1035             


Ser Asp  Met Leu Glu Glu Tyr  Glu Ala Lys Ser Thr  Ala Asp Ser 
    1040                 1045                 1050             


Arg Gln  Ser Val Tyr Gln Leu  Glu His Pro Ala Phe  Thr His Pro 
    1055                 1060                 1065             


Lys Arg  Glu Arg Trp Lys Gln  Gly Thr 
    1070                 1075         


<210>  2125
<211>  1362
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2125

Met Pro Asn Val Lys Phe Thr Leu Val Pro Val Asp Tyr Ser Arg Pro 
1               5                   10                  15      


Tyr Glu Glu Gln Pro Glu Cys Lys Arg His Val Ile Gly Ala Tyr Ala 
            20                  25                  30          


Asn Leu Ala Arg His Asn Met Thr Leu Thr Ile Asn Thr Ile Met Gln 
        35                  40                  45              


Thr Ile Gly Met Pro Leu Phe Asn Glu Asn Glu Ile Glu Asn Ala Phe 
    50                  55                  60                  


Ser Lys Ser His Arg Met Glu Leu Asp Thr Leu Asp Ser Thr Gln Lys 
65                  70                  75                  80  


Leu Asn Leu Gln Lys Arg Phe Tyr Arg His Phe Pro Phe Phe Lys Arg 
                85                  90                  95      


Leu Lys Leu Glu Asp Glu Lys Lys Lys Ser Val Gln Leu Gly Lys Leu 
            100                 105                 110         


Leu Gly Ile Met Ser Asp Leu Thr Glu Cys Met Thr Met Leu Arg Asn 
        115                 120                 125             


Thr Tyr Thr His Tyr His Pro Tyr Val Ala Pro Asn Lys Ala Val Gln 
    130                 135                 140                 


Gln Leu Glu Leu Lys Lys Arg Ile Gly Lys Leu Ile Asp Gln Leu Phe 
145                 150                 155                 160 


Glu Asn Ser Thr Arg Ile Tyr Lys Lys Gly Glu Lys Ile Pro His Glu 
                165                 170                 175     


Gly Asn Glu Leu Phe Thr Ser Gln Arg Lys Leu Thr Lys Lys Glu Ile 
            180                 185                 190         


Asn Ile Leu Arg Asn Ser Asp Ser Ser Phe Asp Glu Thr Leu Lys Thr 
        195                 200                 205             


Val Gln Ala Glu Ile Glu Lys Arg Lys Lys Asn Tyr Gln Thr Glu Leu 
    210                 215                 220                 


Lys Lys Arg Gln Glu Leu Ile Ala Lys Gly Ile Lys Pro Asn Lys Glu 
225                 230                 235                 240 


Leu Glu Pro Val Ser Glu Thr Glu Val Lys Ile Gly Lys Asp Thr Tyr 
                245                 250                 255     


Ile Val Gly Ser Asn Gly Thr Ser Ile Lys Lys Ile Trp Asn Gln Tyr 
            260                 265                 270         


Asp Arg Asp Pro Asp Tyr Tyr Ala Arg Met Cys Asp Asp Glu Lys Gly 
        275                 280                 285             


Leu Ser Asp Ala Gly Ile Val Tyr Phe Ile Cys Leu Phe Leu Asp Lys 
    290                 295                 300                 


Gln Val Ala Ser Asp Phe Met Asp Glu Val Gly Phe Thr Glu Gln Cys 
305                 310                 315                 320 


Tyr Phe Ser Glu Ser Asn Ile Ile Met Leu Lys Glu Leu Met Ser Leu 
                325                 330                 335     


Asn Arg Ile Arg Met Val Lys Met Arg Leu Asp Ser Glu Met Asn Glu 
            340                 345                 350         


Thr Ala Leu Ala Leu Asp Met Met Ser Glu Leu Arg Lys Cys Pro Gln 
        355                 360                 365             


Pro Leu Tyr Asp Val Leu Asp Thr Ser Ala Arg Asn Asp Phe Lys Asp 
    370                 375                 380                 


Ala Thr Thr Val Lys Trp Glu Met Glu His Gln Gln Glu Ala Thr Val 
385                 390                 395                 400 


Ser Tyr Asn Gln Gln Glu Asp Glu Asp Asn Glu Phe Ala Pro Gln Lys 
                405                 410                 415     


Ser Thr Pro Arg Ser Thr Phe Val Arg Trp Asp Asp Arg Phe Ser Glu 
            420                 425                 430         


Leu Ala Leu Gln Tyr Ile Asp Arg Trp Lys Pro Phe Asn Asp Ile Arg 
        435                 440                 445             


Phe His Leu Asn Leu Gly Lys Tyr Arg Phe Ala Phe Tyr Asn His Thr 
    450                 455                 460                 


Ser Glu Gln Ser Val Asp Gly Arg Glu Arg Leu Arg Ile Leu Gln Lys 
465                 470                 475                 480 


Glu Leu His Gly Phe Gly Arg Ile Gln Glu Val Glu Ala Val Leu Lys 
                485                 490                 495     


Glu Arg Trp Lys Lys Asn Phe Asp Gln Lys Glu Val Glu Asp Gly Leu 
            500                 505                 510         


Ile Lys Lys Lys Pro Asp Thr Glu Gly Gln Ala Pro Tyr Val Thr Glu 
        515                 520                 525             


Gln Arg Pro Arg Tyr Asn Ile Asp Lys Lys Ser Asn Ser Ile Gly Leu 
    530                 535                 540                 


Arg Trp Glu Gly Trp Asp Asn Gly Gly Asn Gln Thr Val Lys Arg Lys 
545                 550                 555                 560 


Asp Gly Thr Val Phe Thr Thr Gly His Tyr Gly Asp Leu Ala Glu Lys 
                565                 570                 575     


Lys Met Phe Ile Pro Asn Ile Pro Arg Pro Ala Ser Thr Asp Pro Thr 
            580                 585                 590         


Lys His Glu Asn Lys Ala Glu Arg Leu Leu Gln Pro Gln Cys Met Leu 
        595                 600                 605             


Asn Leu Phe Asp Leu Pro Ala Leu Val Phe His Arg Tyr Leu Leu Glu 
    610                 615                 620                 


Lys Tyr Arg Lys Asp Val Ser Leu Thr Glu Gln Ile Ile Lys Gly Cys 
625                 630                 635                 640 


Tyr Asn Ser Met His Ser Phe Leu Thr Asp Leu Ser Lys Gly Thr Ile 
                645                 650                 655     


Phe Pro Leu Glu His Tyr Gln Ile Lys Val Thr Asp Ile Pro Asp Arg 
            660                 665                 670         


Ile Arg Gln Leu Leu Glu Gly Lys Gln Pro Asp Asn Val Glu Arg Leu 
        675                 680                 685             


Lys Glu Ser Ala Met Arg Lys Leu Lys Glu Arg Lys Ala Arg Ile Glu 
    690                 695                 700                 


Arg Thr Gln Lys Ser Tyr Tyr Glu Lys Lys Asp Arg Ile Gly Asn Lys 
705                 710                 715                 720 


Asp Asn Lys Phe Asp Lys Met Arg Ala Thr Ile Lys Thr Gly Gln Leu 
                725                 730                 735     


Gly Arg Trp Leu Met Gln Asp Ile Met Asp Trp Ile Pro Gln His Ser 
            740                 745                 750         


Glu Ala Arg Gln Lys Leu Thr Gly Gln Thr Tyr Met Val Leu Gln Ser 
        755                 760                 765             


Ser Leu Thr Leu Leu Gly Gln Lys Ile Asn Glu Asp Ser Leu Ser Thr 
    770                 775                 780                 


Thr Ile Thr Leu Lys Lys Leu Lys Val Met Met Val Asn Ala Lys Ile 
785                 790                 795                 800 


Val Glu Glu Asp Ile Val Gly Asn Lys Thr Asp Ala Leu Ile Tyr His 
                805                 810                 815     


Pro Phe Leu His Leu Val Phe Ser Glu Cys Tyr Asp Asp Ser Val Glu 
            820                 825                 830         


Ala Phe Tyr Glu Lys Tyr Leu Glu Lys Glu Leu Asn Arg Ile Gln Gln 
        835                 840                 845             


Met Ile Asp Trp Ile Ser Lys Pro Val Ser Asn Asp Ala Ile Leu Gly 
    850                 855                 860                 


Arg Tyr Arg Tyr Thr Pro Phe Ile His His Glu Arg Thr Arg Trp Lys 
865                 870                 875                 880 


Pro Val Asn Ser Glu Thr Leu Lys Leu Leu Ala Thr Arg Tyr Leu Glu 
                885                 890                 895     


Arg Pro Leu Gln Leu Pro Lys Gly Leu Phe Thr Glu Ser Ile Arg Val 
            900                 905                 910         


Leu Leu Asn Glu Ile Ala Leu Glu Asn Gly Leu Thr Ala Asp Lys Val 
        915                 920                 925             


Asn Leu Phe Ala Asn Ala Val Asn Ala Ala Gln Met Ile Ser Leu Tyr 
    930                 935                 940                 


His Thr Leu Ile Glu Gly Asp Asp Ser Gln Arg Phe Tyr His Asn Glu 
945                 950                 955                 960 


Pro Thr Lys Ile Gly Thr Ile Lys Asn Pro Asn Ala Tyr Gly His Leu 
                965                 970                 975     


Tyr Arg Leu Phe Lys Lys Leu Tyr Gly Asn Pro Asn Glu Asn Ser Asn 
            980                 985                 990         


Arg Ile Tyr Lys Phe Ser Thr Pro  Glu Ile Asn Arg Ile  Leu Thr Gly 
        995                 1000                 1005             


Asn Ile  Asp Ala Ile Thr Ser  Thr Asn Gln Leu Leu  Lys Ile Lys 
    1010                 1015                 1020             


Arg Leu  Asp Tyr Lys Ile Tyr  Glu Tyr Ile Ile Lys  Glu Met Lys 
    1025                 1030                 1035             


Lys Glu  Gly Thr Leu Lys Pro  Ile Asp Val His Leu  Ile Val Leu 
    1040                 1045                 1050             


Asp Arg  Lys Tyr Ala Asp Leu  Asn Asp Tyr Glu Glu  Ala Thr Thr 
    1055                 1060                 1065             


Val Gln  Glu Arg Leu Ala Ile  Asp Lys Leu Leu Lys  Glu Ile Leu 
    1070                 1075                 1080             


Lys Lys  Leu Lys Asn Tyr Glu  Val Asp Met Ile Trp  Glu Tyr Tyr 
    1085                 1090                 1095             


Met Lys  Met Lys Arg Met Ala  Lys Lys Val Ala Ser  Asn Glu Arg 
    1100                 1105                 1110             


Ala Ile  Leu Arg Tyr Lys Thr  Gln Asp Val Leu Leu  Leu Tyr Met 
    1115                 1120                 1125             


Ala Arg  Asn Ile Leu Met Ala  Lys Ser Asn Asn Ala  Glu Ser Phe 
    1130                 1135                 1140             


Lys Glu  Gly Phe Met Leu Glu  Asn Val Arg Gln Gly  Asp Ala Leu 
    1145                 1150                 1155             


Leu Asp  Lys Thr Ile Asn Phe  Glu Trp Lys Val Met  Ile Val Ser 
    1160                 1165                 1170             


Gly Thr  Pro Asp Leu Glu Glu  Lys Gln Gln Cys Ser  Lys Thr Ile 
    1175                 1180                 1185             


Val Gln  Asn Asn Met Lys Met  Lys Asn Tyr Gly Gln  Phe Tyr Lys 
    1190                 1195                 1200             


Phe Ala  Ser Asp His Gln Arg  Leu Ser Ser Leu Leu  Ser Arg Leu 
    1205                 1210                 1215             


Pro Asp  Asp Ile Phe Gln Arg  Ala Glu Ile Glu Asn  Glu Phe Ala 
    1220                 1225                 1230             


Tyr Tyr  Asp Thr Asn Arg Ser  Glu Val Phe Arg Gln  Val Tyr Ile 
    1235                 1240                 1245             


Ile Glu  Ser Glu Ala Tyr Lys  Leu Lys Pro Glu Leu  Thr Asp Asp 
    1250                 1255                 1260             


Ala Asn  Ala Tyr Lys Glu Trp  Phe Thr Phe Ile Asp  Lys Lys Ser 
    1265                 1270                 1275             


Gly Lys  Pro Arg Ala Lys Arg  Asn Asn Phe Gly Glu  Leu Leu Lys 
    1280                 1285                 1290             


Ile Leu  Ala Ala Gly Gly Asp  Gly Val Leu Asp Asp  Val Glu Lys 
    1295                 1300                 1305             


Ser Leu  Leu Gln Ser Thr Arg  Asn Ala Phe Gly His  Asn Thr Tyr 
    1310                 1315                 1320             


Asp Val  Asp Met Pro Val Val  Phe Asn Gly Lys Gln  Asp Lys Met 
    1325                 1330                 1335             


Lys Val  Pro Glu Val Ala Asn  Gly Ile Lys Glu Lys  Ile Leu Glu 
    1340                 1345                 1350             


Gln Thr  Glu Lys Leu Lys Lys  Asn Val 
    1355                 1360         


<210>  2126
<211>  935
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (3)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  2126

Leu Phe Xaa Xaa Ser Gly Asn Val Lys Arg Tyr Val Arg Asn Pro Asp 
1               5                   10                  15      


Tyr Pro Ala Tyr Met Met Asp Glu Lys Glu Gly Met Ser Asp Ile Ala 
            20                  25                  30          


Ile Ile Tyr Phe Leu Cys Leu Phe Leu Glu Lys Lys Val Ser Phe Glu 
        35                  40                  45              


Leu Met Glu Glu Val Gly Leu Thr Lys Gln Ile Lys Phe Lys Gly Arg 
    50                  55                  60                  


Asp Ala Asp Gln Gln Leu Leu Phe Val Lys Glu Ile Leu Cys Met Asn 
65                  70                  75                  80  


Arg Ile Arg Met Thr Lys Thr Lys Leu Asp Ser Glu Met Thr Asp Thr 
                85                  90                  95      


Ala Leu Ala Leu Asp Met Ile Asn Glu Leu Arg Lys Cys Pro Lys Pro 
            100                 105                 110         


Leu Tyr Glu Val Leu Asp Arg Glu Ala Arg Glu Glu Phe Lys Asp Asp 
        115                 120                 125             


Ala Thr Ile Gln Trp Glu Met Asp His Gly Lys Glu Ala Val Glu Thr 
    130                 135                 140                 


Glu Asp Ser Glu Asn Glu Asp Gly Asn Glu Ala Pro Thr Glu Lys Asp 
145                 150                 155                 160 


Thr Pro Arg Ser Thr Phe Val Arg Trp Gln Asp Arg Phe Pro Gln Met 
                165                 170                 175     


Ala Leu Ser Tyr Ile Asp Tyr Arg Gly Leu Phe Gln Asp Ile Arg Phe 
            180                 185                 190         


Gln Leu Asn Leu Gly Lys Tyr Arg Phe Ala Phe Tyr Thr His Asp Lys 
        195                 200                 205             


Glu Thr Ser Ile Asp Gly Ser Glu Arg Leu Arg Ile Leu Gln Lys Glu 
    210                 215                 220                 


Leu His Gly Phe Gly Arg Ile Gln Glu Val Glu Ala Lys Lys Asn Glu 
225                 230                 235                 240 


Lys Trp Ala Gly Leu Phe Asp Glu Lys Tyr Val Glu Asp Gly Leu Thr 
                245                 250                 255     


Gln Lys Lys Pro Asp Glu Ala Gly Gln Ala Pro Tyr Ile Thr Glu Gln 
            260                 265                 270         


Arg Ala Gln Tyr Ala Ile Asp Glu Lys Ser His Ser Ile Gly Leu Arg 
        275                 280                 285             


Trp Glu Gly Trp Arg Ala Ala Ala Asp Ser Arg Asn His Tyr Gly Asp 
    290                 295                 300                 


Leu Asp Ser Gln Lys Met Phe Ile Pro Tyr Ile Pro Ala Asn Pro Ala 
305                 310                 315                 320 


Ser Gln Glu Gly Thr Arg Gln Lys Asn Gln Ala Glu Gly Leu Leu Arg 
                325                 330                 335     


Pro Gln Ala Met Met Ser Leu Tyr Glu Leu Pro Gly Leu Leu Phe Tyr 
            340                 345                 350         


Gln Tyr Leu Leu Glu Lys Tyr Gly Lys Asp Lys Phe Val Ala Glu Lys 
        355                 360                 365             


Leu Ile Lys Glu Cys Tyr Ser His Leu Glu Leu Phe Leu Lys Asp Val 
    370                 375                 380                 


Ser Thr Gly Asp Leu Met Pro Val Asn Ser Val Gly Lys Lys Asp Glu 
385                 390                 395                 400 


Leu Ala Lys Ile Leu Asn Glu Lys Tyr Lys Leu Arg Leu Ser Asp Ile 
                405                 410                 415     


Pro Glu Lys Leu Arg Lys Tyr Leu Leu Ser Glu Ser Val Asp Cys Ala 
            420                 425                 430         


Glu Lys Leu Lys Asp Ser Ala Tyr His Arg Leu Ala Glu Arg Lys Glu 
        435                 440                 445             


Arg Ile Glu Arg Ile Leu Lys Gln Tyr Arg Glu Lys Cys Lys Arg Ile 
    450                 455                 460                 


Gly Thr Lys Glu Asn Lys Phe Asn Lys Lys Arg Ala Ser Ile Lys Thr 
465                 470                 475                 480 


Gly Ala Leu Ala Gln Ala Leu Met Arg Asp Ile Met Asp Trp Leu Pro 
                485                 490                 495     


Leu Asp Ser Glu Ala Arg Thr Lys Leu Thr Gly Gln Ser Tyr Met Ala 
            500                 505                 510         


Leu Gln Ala Ala Phe Ala Val Leu Gly Gln Glu Phe Thr Asp Glu Glu 
        515                 520                 525             


Gly Asn Ser Gln Val Met Asn Met Gln Ala Leu Arg Ser Ile Leu Ile 
    530                 535                 540                 


Asn Ala Lys Val Leu Asp Glu Lys Thr Glu Lys Ile Asp Gln Lys Cys 
545                 550                 555                 560 


Phe His Pro Phe Leu His Leu Val Phe Arg Asp Cys Lys Glu Glu Phe 
                565                 570                 575     


Leu Gly Lys Phe Tyr Glu Met Tyr Leu Glu Lys Glu Leu Glu Lys Ile 
            580                 585                 590         


Asp Leu Val Val Lys Phe Leu Asp Gly Ala Asp Gly Asp Tyr Asp Leu 
        595                 600                 605             


Leu Arg Asn Arg Tyr Arg Tyr Val Pro Phe Leu His His Glu Arg Glu 
    610                 615                 620                 


Arg Trp Ser Leu Arg Asp Ala Gly Ala Met Lys Arg Leu Ala Ala His 
625                 630                 635                 640 


Tyr Leu Glu Leu Pro Leu Arg Leu Pro Asp Gly Leu Phe Ala Gln Ala 
                645                 650                 655     


Ile Tyr Ser Phe Leu Gln Glu Val Pro Gln Asn Glu Val Pro Gln Lys 
            660                 665                 670         


Leu Trp Asp Arg Phe Arg Lys Lys Leu Lys Glu Ala Asn Glu Gly Glu 
        675                 680                 685             


Pro Gln Leu Arg Leu Ser Gly Asn Val Ser Tyr Leu Ile Asn Leu Tyr 
    690                 695                 700                 


Phe Asn Asn Val Glu Asn Asp His Ser Gln His Phe Tyr Ile Thr Asp 
705                 710                 715                 720 


Pro Ile Asp Thr Pro Pro Ser Ala Tyr Arg His Ile Tyr Arg Val Phe 
                725                 730                 735     


Lys Arg Tyr Phe Gly Glu Lys Ile Pro His Thr Asn Arg Thr Thr Thr 
            740                 745                 750         


Pro Ala Tyr Thr Ile Asp Glu Ile Arg Glu Ile Leu Lys Asp Lys Glu 
        755                 760                 765             


Thr Leu Lys Ala Arg Ile Asp Ala Tyr Ile Lys Lys Asp Val Asp Lys 
    770                 775                 780                 


Phe Arg Gly Gly Lys Trp Glu Lys Phe Arg Thr Arg Gln Arg Lys Tyr 
785                 790                 795                 800 


Glu Glu Glu Leu Trp Ala Glu Leu Lys Gln Gln Val Arg Lys His Gln 
                805                 810                 815     


Arg Arg Trp Asp Val Asp Glu Phe Asp Lys Glu Val Arg Gln Lys Leu 
            820                 825                 830         


Asn Glu Arg Lys Ala Lys Phe Asp Glu Met Ile Glu Gln Phe Arg Met 
        835                 840                 845             


Pro Leu Phe Arg Lys Gln Glu Arg Met Phe Lys Lys Val Ala Asp Asn 
    850                 855                 860                 


Glu Arg Ser Ile Arg Arg Phe Lys Thr Gln Asp Ile Leu Met Leu Ile 
865                 870                 875                 880 


Met Ala Arg Glu Ile Leu Lys Ala Lys Ser Gln Asp Lys Asp Phe Thr 
                885                 890                 895     


Lys Asp Phe Cys Leu Lys Tyr Val Met Thr Asp Ser Leu Leu Asp Lys 
            900                 905                 910         


Pro Ile Asp Phe Thr Trp Thr Val Thr Ile Lys Asp Lys Asp Lys Gly 
        915                 920                 925             


Ser Arg Thr Lys Ser Ile Val 
    930                 935 


<210>  2127
<211>  1199
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2127

Met Asn Thr Phe Ile Asp Ser Phe Ile Arg Arg Val Gln Ile Gln Asn 
1               5                   10                  15      


Gln Asn Gln Ser Trp Pro Lys Arg Pro Lys Tyr Val Arg Pro Val Glu 
            20                  25                  30          


Asn Ile Arg Pro Asp Asp Leu Ala Phe Gln Ser His Phe Thr Ala Tyr 
        35                  40                  45              


Leu Asn Met Ala Arg Gln Asn Cys Cys Ile Ile Leu Gly His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Gly Phe Lys Ala Ser Ser Val Lys Asp Thr Thr Leu Thr 
65                  70                  75                  80  


Ser Ser Pro Leu Leu Gly Gln Asn Gly Leu Leu Ser Pro Lys Lys Glu 
                85                  90                  95      


Val Ser Asp Leu Ile Arg Gly Arg Leu Leu Ser Ala Phe Pro Met Leu 
            100                 105                 110         


Asp Pro Met Ile Arg Tyr Arg Lys Ala Val Asp Lys Glu Lys Asp Asp 
        115                 120                 125             


Tyr Ala Arg Ile Ile Ile Thr Ser Glu Asp Val Ser Glu Met Leu Arg 
    130                 135                 140                 


Asp Leu Leu Asp Val Leu Ser Tyr Tyr Arg Asp Met Ala Ser His Val 
145                 150                 155                 160 


Val Phe Asn Asp Asp Arg Ser Val Ser Ala Glu Phe Ala Ser Lys Glu 
                165                 170                 175     


Lys Lys Val Ala Glu Cys Leu Asn Tyr Met Met Thr Val Ser Leu Arg 
            180                 185                 190         


Ile Val Lys Asp Arg Phe Ser Leu Ala Val Ser Asp Leu Asp Phe Tyr 
        195                 200                 205             


Asn Arg Asn Arg Tyr Met Met Val Asn Arg Lys Pro Leu Leu Asn Ala 
    210                 215                 220                 


Gly Phe Ala His Ala Val Arg Thr Glu Asp Tyr Arg Leu Thr Leu Met 
225                 230                 235                 240 


Gly Leu Val Leu Leu Cys Cys Gln Phe Ile Glu Lys Gln Tyr Ala Ser 
                245                 250                 255     


Met Phe Phe Asp Ala Leu Asp Lys His Ser Asn Gly Ala Arg Phe Tyr 
            260                 265                 270         


Gly Ile Ala Asp Ala Met Pro Met Val Asn Val Gly Thr Lys Asp Lys 
        275                 280                 285             


Pro Lys Lys Ile Pro Met Tyr Thr Gly Asp Glu Ala Gln Lys Gln Val 
    290                 295                 300                 


Gln Lys Gln Arg Met Ala Leu Arg Glu Ala Tyr Ser Val Tyr Arg Val 
305                 310                 315                 320 


Arg Ile Pro Lys Glu Arg Leu Glu Ser Thr Arg Ser Asp Met Ala Leu 
                325                 330                 335     


Ala Leu Asp Ile Leu Asn Glu Leu Gly Lys Cys Pro Glu Glu Leu Phe 
            340                 345                 350         


Glu His Leu Ser Pro Glu Asp Arg Glu Ser Phe Lys Asn Glu Glu Gly 
        355                 360                 365             


Val Leu Met Lys Arg Tyr Ser Asp Arg Phe Pro Gln Leu Ala Leu Arg 
    370                 375                 380                 


Trp Leu Asp Glu Asn Glu Lys Phe Asn Asn Leu Arg Phe His Val Thr 
385                 390                 395                 400 


Phe Gly Lys Tyr Arg Trp Leu Phe Cys Gln Asp Lys Lys Cys Ala Asp 
                405                 410                 415     


Gly Ser Val Arg Pro Arg Trp Leu Gln Lys Glu Leu Asn Gly Phe Gly 
            420                 425                 430         


Arg Ile Gln Thr Val Glu Arg Lys Arg Thr Gly Leu Glu Pro Gly Trp 
        435                 440                 445             


Asp Gly Thr Gly Leu Ile Arg Lys Phe Glu Glu Val Val Thr Asp Glu 
    450                 455                 460                 


Val Gln Lys Glu Pro Tyr Ile Thr Asp Phe Arg Thr Gln Tyr Leu Phe 
465                 470                 475                 480 


Asn Arg Asp Lys Ile Gly Ile Ser Leu Ser Glu Tyr Met Pro Gly Ile 
                485                 490                 495     


Gly Asp Ile His Ser Gly Lys Glu Trp Gly Lys His Ala Gly Val Pro 
            500                 505                 510         


Asp Phe Tyr Leu Ser Val Tyr Asp Ile Pro Ala Met Leu Phe Leu Thr 
        515                 520                 525             


Trp Leu Leu Gly Lys Asn Ser Ser Ala Val Glu Lys Leu Leu Ala Asn 
    530                 535                 540                 


Cys Lys Ala Ala Tyr Met Lys Leu Phe Asp Asp Leu Ala Lys Gly Lys 
545                 550                 555                 560 


Trp Glu Gly Glu Arg Asn Val Ser Asp Tyr Cys Ala Gly Glu Gly Thr 
                565                 570                 575     


Val Arg Tyr Thr Leu Arg Trp Tyr Asp Val Pro Met Lys Ile Arg Arg 
            580                 585                 590         


Lys Met Pro Leu Leu Gly Gly Asp Arg Asp Phe Glu Glu Lys Lys Ser 
        595                 600                 605             


Phe Glu Thr Leu Ala Gln Glu Ala Leu Thr Arg Met Leu Gln Arg Thr 
    610                 615                 620                 


Glu Asn Gln Leu Glu Lys Phe Asp Arg Asp Leu Ala Ala Ala Arg Asp 
625                 630                 635                 640 


Leu Lys Ala Asn Lys Gln Gly Lys Asp Arg Phe Val Asp Ile Arg Ala 
                645                 650                 655     


Gly Ser Leu Ala Thr Phe Leu Ala Arg Asp Ile Val Arg Leu Met Pro 
            660                 665                 670         


Val Ser Asp Asn Gly Arg Asn Lys Pro Thr Gly Leu Asn Tyr Ser Ile 
        675                 680                 685             


Val Gln Lys Ala Ile Ala Thr Tyr Lys Pro Ser Glu Gly Gly Leu Asp 
    690                 695                 700                 


Thr Leu Thr Gly Val Phe Arg Asp Ala Arg Ile Ile Gly Val Lys Gly 
705                 710                 715                 720 


Gly Ser His Pro Phe Leu Glu Arg Leu Leu Val Glu Lys Lys Pro Ser 
                725                 730                 735     


Ser Val Leu Ala Leu Tyr Arg His Tyr Leu Glu Tyr Arg Lys Glu Tyr 
            740                 745                 750         


Leu Lys Lys Ala Leu Glu Asp Glu Asn Lys Ala Glu Leu Lys Asn Leu 
        755                 760                 765             


Pro Phe Leu Lys Ser Gly Arg Gln Lys Tyr Ala Val Asp Gln Ala Asp 
    770                 775                 780                 


Tyr Ala Arg Arg Leu Ala Glu Ser Tyr Arg Asn Cys Pro Ile Tyr Leu 
785                 790                 795                 800 


Pro Thr Gly Ile Phe Thr Asp Met Leu Lys Asp Gln Leu Ala Lys Ile 
                805                 810                 815     


Asp Val Met Lys Pro Val Leu Glu Asn Asp Lys Val Asn Ala Ser Tyr 
            820                 825                 830         


Leu Ile Ala Gln Tyr Phe Glu Lys Val Glu His Asp Ser Glu Gln Pro 
        835                 840                 845             


Leu Tyr Arg Leu Lys Arg Asn Tyr Arg Val Phe Asp Leu Leu Glu Phe 
    850                 855                 860                 


Thr Asp Glu Pro Lys Tyr Trp Arg Leu Asn Glu Arg Ser Asp Lys Ala 
865                 870                 875                 880 


Gly Lys Tyr Gly Leu Ala Lys Arg Asn Ile Phe Trp Asn Arg Met Gly 
                885                 890                 895     


Glu Tyr Tyr Lys Gly Leu Lys Lys Phe Tyr Lys Gly Tyr Glu Ser Lys 
            900                 905                 910         


Arg Thr Ala Val Asp Trp Arg Glu Lys Leu Lys Ile Val Glu Ala Glu 
        915                 920                 925             


His Ala Met Trp Asn Arg Leu Lys Asp Ala Ser Gly Glu Ala Arg Leu 
    930                 935                 940                 


Lys Met Lys Asp Gly Val Phe Tyr Ser Arg Leu Leu Ser Ala Arg Lys 
945                 950                 955                 960 


Glu Tyr Asp Asp Cys Glu Arg Ala Leu Arg Arg Leu Lys Val Gln Asp 
                965                 970                 975     


Ile Val Leu Phe Leu Ala Ala Arg Glu Thr Leu Ile Leu Pro Lys Asp 
            980                 985                 990         


Lys Val Phe Arg Leu Lys Asn Leu  Ser Leu Ser Glu Gly  Asn Lys Asn 
        995                 1000                 1005             


Ile Leu  Ser Ser Ala Ile Asp  Glu Phe Ser Val Asp  Val Val Trp 
    1010                 1015                 1020             


Thr Glu  Lys Glu Gly Ala Ala  Lys Val Thr His Ser  Ala Ser Ile 
    1025                 1030                 1035             


Lys Glu  Asn Asp Val Val Ile  Lys Asn Tyr Gly Arg  Met Phe Arg 
    1040                 1045                 1050             


Leu Leu  His Asp Asp Arg Val  Lys Thr Leu Leu Pro  His Ile Tyr 
    1055                 1060                 1065             


Asp Ser  Ala Leu Ser Glu Asn  Ile Thr Gly Asp Arg  Ile Thr Val 
    1070                 1075                 1080             


Lys Asp  Asn Lys Val Ile Ile  Asp Lys Ser Leu Phe  Asp Glu Asp 
    1085                 1090                 1095             


Leu Met  Asn Tyr Asp Leu Arg  Arg His Glu Ile Cys  Glu Ile Ile 
    1100                 1105                 1110             


Leu Arg  Phe Glu Ala Ala Ser  Ile Lys Arg Phe Gly  Leu Asp Gly 
    1115                 1120                 1125             


Arg Val  Asp Phe Lys Ala Ala  Leu Asp Ala Leu Thr  Gly Arg Ser 
    1130                 1135                 1140             


Leu Leu  Asn Asp Glu Asp Ala  Arg Ile Leu Ser Ala  Ile Arg Asn 
    1145                 1150                 1155             


Ala Tyr  Asn His Asn Lys Tyr  Pro Ala Lys Gly Thr  Asp Val Lys 
    1160                 1165                 1170             


Val Asn  Val Met Ala Leu Pro  Lys Leu Thr Glu Asp  Leu Leu Arg 
    1175                 1180                 1185             


Ile Phe  Ser Asp Thr Gly Asn  Asn Arg Val Arg 
    1190                 1195                 


<210>  2128
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2128

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Ala Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Asn Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2129
<211>  985
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2129

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Asn Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys Gly Tyr 
                165                 170                 175     


Ala Phe Phe Ile Ser Lys Phe Leu Glu Arg Lys Tyr Ser Tyr Leu Phe 
            180                 185                 190         


Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln Tyr Arg 
        195                 200                 205             


Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro Val Glu 
    210                 215                 220                 


Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu Asp Ile 
225                 230                 235                 240 


Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr Leu Glu 
                245                 250                 255     


Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr Asp Ala 
            260                 265                 270         


Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe Arg Ser 
        275                 280                 285             


Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala Asp Phe 
    290                 295                 300                 


Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His Asn Gly 
305                 310                 315                 320 


Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr Ile Asn 
                325                 330                 335     


Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser Ala Lys 
            340                 345                 350         


Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser Thr Asp 
        355                 360                 365             


Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln Ser Thr 
    370                 375                 380                 


Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val Leu Pro 
385                 390                 395                 400 


Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala Lys Met 
                405                 410                 415     


Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala Met Leu 
            420                 425                 430         


Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His Cys Pro 
        435                 440                 445             


Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser Thr Lys 
    450                 455                 460                 


Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg Val Met 
465                 470                 475                 480 


Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu Arg Ile 
                485                 490                 495     


Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile Leu Lys 
            500                 505                 510         


Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp Leu Gln 
        515                 520                 525             


Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn Phe Gln 
    530                 535                 540                 


Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn Asp Leu 
545                 550                 555                 560 


Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn Pro His 
                565                 570                 575     


Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile Glu Phe 
            580                 585                 590         


Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg Ile Gln 
        595                 600                 605             


Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro Leu Arg 
    610                 615                 620                 


Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu Ala Ile 
625                 630                 635                 640 


Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys Leu Lys 
                645                 650                 655     


Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu Lys Ser 
            660                 665                 670         


Pro Ala Leu Asn Val Ser Tyr Leu Ile His Asn Tyr Phe Arg Ala Tyr 
        675                 680                 685             


Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn Tyr Arg 
    690                 695                 700                 


Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser Tyr Leu 
705                 710                 715                 720 


Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro Ser Lys 
                725                 730                 735     


Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp Arg Leu 
            740                 745                 750         


Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile Ile Arg 
        755                 760                 765             


Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys Glu Tyr 
    770                 775                 780                 


Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu Glu Asn 
785                 790                 795                 800 


Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp Leu Asn 
                805                 810                 815     


Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr Gly Lys 
            820                 825                 830         


Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn Lys Val 
        835                 840                 845             


Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val Lys Ile 
    850                 855                 860                 


Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu Glu Ala 
865                 870                 875                 880 


Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala Met Val 
                885                 890                 895     


Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr Tyr Asp 
            900                 905                 910         


Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln Lys Ile 
        915                 920                 925             


Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His Asp Lys 
    930                 935                 940                 


Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val Tyr Ala 
945                 950                 955                 960 


Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile Lys Leu 
                965                 970                 975     


Glu Asp Leu Ser Asn Asp Ser Ser Ala 
            980                 985 


<210>  2130
<211>  1199
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2130

Met Asn Thr Phe Ile Asp Ser Phe Ile Arg Arg Val Gln Ile Gln Asn 
1               5                   10                  15      


Gln Asn Gln Ser Trp Pro Lys Arg Pro Lys Tyr Val Arg Pro Val Glu 
            20                  25                  30          


Asn Ile Arg Pro Asp Asp Leu Ala Phe Gln Ser His Phe Thr Ala Tyr 
        35                  40                  45              


Leu Asn Met Ala Arg Gln Asn Cys Cys Ile Ile Leu Gly His Leu Ser 
    50                  55                  60                  


Gln Ser Leu Gly Phe Lys Ala Ser Ser Val Lys Asp Thr Thr Leu Thr 
65                  70                  75                  80  


Ser Ser Pro Leu Leu Gly Gln Asn Gly Leu Leu Ser Pro Lys Lys Glu 
                85                  90                  95      


Val Ser Asp Leu Ile Arg Gly Arg Leu Leu Ser Ala Phe Pro Met Leu 
            100                 105                 110         


Asp Pro Met Ile Arg Tyr Arg Lys Ala Val Asp Lys Glu Lys Asp Asp 
        115                 120                 125             


Tyr Ala Arg Ile Ile Ile Thr Ser Glu Asp Val Ser Glu Met Leu Arg 
    130                 135                 140                 


Asp Leu Leu Asp Val Leu Ser Tyr Tyr Arg Asp Met Ala Ser His Val 
145                 150                 155                 160 


Val Phe Asn Asp Asp Arg Ser Val Ser Ala Glu Phe Ala Ser Lys Glu 
                165                 170                 175     


Lys Lys Val Ala Glu Cys Leu Asn Tyr Met Met Thr Val Ser Leu Arg 
            180                 185                 190         


Ile Val Lys Asp Arg Phe Ser Leu Ala Val Ser Asp Leu Asp Phe Tyr 
        195                 200                 205             


Asn Arg Asn Arg Tyr Met Met Val Asn Arg Lys Pro Leu Leu Asn Ala 
    210                 215                 220                 


Gly Phe Ala His Ala Val Arg Thr Glu Asp Tyr Arg Leu Thr Leu Met 
225                 230                 235                 240 


Gly Leu Val Leu Leu Cys Cys Gln Phe Ile Glu Lys Gln Tyr Ala Ser 
                245                 250                 255     


Met Phe Phe Asp Ala Leu Asp Lys His Ser Asn Gly Ala Arg Phe Tyr 
            260                 265                 270         


Gly Ile Ala Asp Ala Met Pro Met Val Asn Val Gly Thr Lys Asp Lys 
        275                 280                 285             


Pro Lys Lys Ile Pro Met Tyr Thr Gly Asp Glu Ala Gln Lys Gln Val 
    290                 295                 300                 


Gln Lys Gln Arg Met Ala Leu Arg Glu Ala Tyr Ser Val Tyr Arg Val 
305                 310                 315                 320 


Arg Ile Pro Lys Glu Arg Leu Glu Ser Thr Arg Ser Asp Met Ala Leu 
                325                 330                 335     


Ala Leu Asp Ile Leu Asn Glu Leu Gly Lys Cys Pro Glu Glu Leu Phe 
            340                 345                 350         


Glu His Leu Ser Pro Glu Asp Arg Glu Ser Phe Lys Asn Glu Glu Gly 
        355                 360                 365             


Val Leu Met Lys Arg Tyr Ser Asp Arg Phe Pro Gln Leu Ala Leu Arg 
    370                 375                 380                 


Trp Leu Asp Glu Asn Glu Lys Phe Asn Asn Leu Arg Phe His Val Thr 
385                 390                 395                 400 


Phe Gly Lys Tyr Arg Trp Leu Phe Cys Gln Asp Lys Lys Cys Ala Asp 
                405                 410                 415     


Gly Ser Val Arg Pro Arg Trp Leu Gln Lys Glu Leu Asn Gly Phe Gly 
            420                 425                 430         


Arg Ile Gln Thr Val Glu Arg Lys Arg Thr Gly Leu Glu Pro Gly Trp 
        435                 440                 445             


Asp Gly Thr Gly Leu Ile Arg Lys Phe Glu Glu Val Val Thr Asp Glu 
    450                 455                 460                 


Val Gln Lys Glu Pro Tyr Ile Thr Asp Phe Arg Thr Gln Tyr Leu Phe 
465                 470                 475                 480 


Asn Arg Asp Lys Ile Gly Ile Ser Leu Ser Glu Tyr Met Pro Gly Ile 
                485                 490                 495     


Gly Asp Ile His Ser Gly Lys Glu Trp Gly Lys His Ala Gly Val Pro 
            500                 505                 510         


Asp Phe Tyr Leu Ser Val Tyr Asp Ile Pro Ala Met Leu Phe Leu Thr 
        515                 520                 525             


Trp Leu Leu Gly Lys Asn Ser Ser Ala Val Glu Lys Leu Leu Ala Asn 
    530                 535                 540                 


Cys Lys Ala Ala Tyr Met Lys Leu Phe Asp Asp Leu Ala Lys Gly Lys 
545                 550                 555                 560 


Trp Glu Gly Glu Arg Asn Val Ser Asp Tyr Cys Ala Gly Glu Gly Thr 
                565                 570                 575     


Val Arg Tyr Thr Leu Arg Trp Tyr Asp Val Pro Met Lys Ile Arg Arg 
            580                 585                 590         


Lys Met Pro Leu Leu Gly Gly Asp Arg Asp Phe Glu Glu Lys Lys Ser 
        595                 600                 605             


Phe Glu Thr Leu Ala Gln Glu Ala Leu Thr Arg Met Leu Gln Arg Thr 
    610                 615                 620                 


Glu Asn Gln Leu Glu Lys Phe Asp Arg Asp Leu Ala Ala Ala Arg Asp 
625                 630                 635                 640 


Leu Lys Ala Asn Lys Gln Gly Lys Asp Arg Phe Val Asp Ile Arg Ala 
                645                 650                 655     


Gly Ser Leu Ala Thr Phe Leu Ala Arg Asp Ile Val Arg Leu Met Pro 
            660                 665                 670         


Val Ser Asp Asn Gly Arg Asn Lys Pro Thr Gly Leu Asn Tyr Ser Ile 
        675                 680                 685             


Val Gln Lys Ala Ile Ala Thr Tyr Lys Pro Ser Glu Gly Gly Leu Asp 
    690                 695                 700                 


Thr Leu Thr Gly Val Phe Arg Asp Ala Arg Ile Ile Gly Val Lys Gly 
705                 710                 715                 720 


Gly Ser His Pro Phe Leu Glu Arg Leu Leu Val Glu Lys Lys Pro Ser 
                725                 730                 735     


Ser Val Leu Ala Leu Tyr Arg His Tyr Leu Glu Tyr Arg Lys Glu Tyr 
            740                 745                 750         


Leu Lys Lys Ala Leu Glu Asp Glu Asn Lys Ala Glu Leu Lys Asn Leu 
        755                 760                 765             


Pro Phe Leu Lys Ser Gly Arg Gln Lys Tyr Ala Val Asp Gln Ala Asp 
    770                 775                 780                 


Tyr Ala Arg Arg Leu Ala Glu Ser Tyr Arg Asn Cys Pro Ile Tyr Leu 
785                 790                 795                 800 


Pro Thr Gly Ile Phe Thr Asp Met Leu Lys Asp Gln Leu Ala Lys Ile 
                805                 810                 815     


Asp Val Met Lys Pro Val Leu Glu Asn Asp Lys Val Asn Ala Ser Tyr 
            820                 825                 830         


Leu Ile Ala Gln Tyr Phe Glu Lys Val Glu His Asp Ser Glu Gln Pro 
        835                 840                 845             


Leu Tyr Arg Leu Lys Arg Asn Tyr Arg Val Phe Asp Leu Leu Glu Phe 
    850                 855                 860                 


Thr Asp Glu Pro Lys Tyr Trp Arg Leu Asn Glu Arg Ser Asp Lys Ala 
865                 870                 875                 880 


Gly Lys Tyr Gly Leu Ala Lys Arg Asn Ile Phe Trp Asn Arg Met Gly 
                885                 890                 895     


Glu Tyr Tyr Lys Gly Leu Lys Lys Phe Tyr Lys Gly Tyr Glu Ser Lys 
            900                 905                 910         


Arg Thr Ala Val Asp Trp Arg Glu Lys Leu Lys Ile Val Glu Ala Glu 
        915                 920                 925             


His Ala Met Trp Asn Arg Leu Lys Asp Ala Ser Gly Glu Ala Arg Leu 
    930                 935                 940                 


Lys Met Lys Asp Gly Val Phe Tyr Ser Arg Leu Leu Ser Ala Arg Lys 
945                 950                 955                 960 


Glu Tyr Asp Asp Cys Glu Arg Ala Leu Arg Arg Leu Lys Val Gln Asp 
                965                 970                 975     


Ile Val Leu Phe Leu Ala Ala Arg Glu Thr Leu Ile Leu Pro Lys Asp 
            980                 985                 990         


Lys Val Phe Arg Leu Lys Asn Leu  Ser Leu Ser Glu Gly  Asn Lys Asn 
        995                 1000                 1005             


Ile Leu  Ser Ser Ala Ile Asp  Glu Phe Ser Val Asp  Val Val Trp 
    1010                 1015                 1020             


Thr Glu  Lys Glu Gly Ala Ala  Lys Val Thr His Ser  Ala Ser Ile 
    1025                 1030                 1035             


Lys Glu  Asn Asp Val Val Ile  Lys Asn Tyr Gly Arg  Met Phe Arg 
    1040                 1045                 1050             


Leu Leu  His Asp Asp Arg Val  Lys Thr Leu Leu Pro  His Ile Tyr 
    1055                 1060                 1065             


Asp Ser  Ala Leu Ser Glu Asn  Ile Thr Gly Asp Arg  Ile Thr Val 
    1070                 1075                 1080             


Lys Asp  Asn Lys Val Ile Ile  Asp Lys Ser Leu Phe  Asp Glu Asp 
    1085                 1090                 1095             


Leu Met  Asn Tyr Asp Leu Arg  Arg His Glu Ile Cys  Glu Ile Ile 
    1100                 1105                 1110             


Leu Arg  Phe Glu Ala Ala Ser  Ile Lys Arg Phe Gly  Leu Asp Gly 
    1115                 1120                 1125             


Arg Val  Asp Phe Lys Ala Ala  Leu Asp Ala Leu Thr  Gly Arg Ser 
    1130                 1135                 1140             


Leu Leu  Asn Asp Glu Asp Ala  Arg Ile Leu Ser Ala  Ile Arg Asn 
    1145                 1150                 1155             


Ala Tyr  Asn His Asn Lys Tyr  Pro Ala Lys Gly Thr  Asp Val Lys 
    1160                 1165                 1170             


Val Asn  Val Met Ala Leu Pro  Lys Leu Thr Glu Asp  Leu Leu Arg 
    1175                 1180                 1185             


Ile Phe  Ser Asp Thr Gly Asn  Asn Arg Val Arg 
    1190                 1195                 


<210>  2131
<211>  1129
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2131

Met Glu Thr Asn Gln Gln Thr His Glu Asn Arg Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Asn Asn His Ile Ala Thr Asp Phe Lys Gln Ala Thr 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ala Ala Phe Leu Cys Asn Lys Thr 
    50                  55                  60                  


Ile Lys Asn Leu Asn Trp Asn His Val His Thr Arg Ala Val Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ser Glu Ser Leu Pro Lys Asp Glu 
                85                  90                  95      


Arg Glu Asn Ser Asp Thr Glu Gly Lys Asp Phe Thr Ser Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Ser Glu Leu Gln Asp Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Asp Ser Arg Lys Leu Ile Val 
    130                 135                 140                 


Ser Pro Glu Leu Ala Asn Phe Leu Thr Val Asn Phe Gln Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Ala Arg Met Lys Asp Val Leu Thr Asp Thr Asp Tyr 
                165                 170                 175     


Ala Leu Val Glu Asn Leu Gln Met Val Ala Pro Asp Asn Lys Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ala Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Thr Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asn Leu Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Ser 
            260                 265                 270         


Val Ile Thr Asp Lys Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Asp Asp Glu Arg 
    290                 295                 300                 


Glu Thr Ile Leu Asp Glu Ile Asp Tyr Gln Asp Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg Tyr Ser Asp Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Asp Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Asn Tyr Thr Lys Gln Phe Ala Gly Glu 
        355                 360                 365             


Gln Ala Glu Arg Lys Val Leu Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asp Pro Glu Leu Ile Gln Gln Arg Ile Asp Lys Gln 
385                 390                 395                 400 


Gln His Thr Ala Gly Phe Asp Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Thr Lys Glu Asn Ile Ala Thr Leu Ile 
            420                 425                 430         


Ala Lys Ser Lys Ala Ser Ser Lys Val Glu His Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Gln Ala Glu Glu Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Ile Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Ser Gln Leu Pro Ala Asn Trp Asp Glu Phe Ser Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asp Ser Thr Leu Lys Tyr Leu 
        515                 520                 525             


Arg Gln Arg Lys Thr Thr Leu Asn Thr Ile Leu Ser Lys Ser Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Lys Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Thr Arg Leu Lys Ala Val Glu Lys His Lys Leu 
            580                 585                 590         


Asn Lys Ser Val Lys Ile Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Glu Glu Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Ala Asn Ala Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Phe Glu Asn Gly Gly His Pro Phe Leu Gln Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Gln Ala Tyr Leu Val 
        675                 680                 685             


Glu Lys Gly Asn Lys Met Val Pro Arg Leu Asn Pro Lys Thr Asn Lys 
    690                 695                 700                 


Thr Ser Lys Val Asp Glu Ser Trp Met Met Lys Gln Phe Tyr Val Lys 
705                 710                 715                 720 


Glu Trp Lys Glu Glu Ile Ala Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Ser Arg Ile Pro Phe Thr Ile Arg Gln Trp Asp Glu Lys 
            740                 745                 750         


Glu Lys Tyr Asp Leu Asn Val Trp Leu Gln His Val Thr Val Gly Lys 
        755                 760                 765             


Asn Lys Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe Asp 
    770                 775                 780                 


Glu Ala Leu Cys Asn Leu Leu Arg Glu Gln Leu Asp Thr Lys Ile Val 
785                 790                 795                 800 


Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Ile Trp Trp 
                805                 810                 815     


Lys Thr Arg Asn Asp Asp Thr Gln Gln Phe Tyr Gln Ser Glu Arg Glu 
            820                 825                 830         


Tyr Asp Ile Tyr Asn Glu Lys Val Arg Phe Lys Ile Asp Ser Ser Thr 
        835                 840                 845             


His Phe Ala Asp Tyr Tyr Lys Asn Ala Leu Ser Arg Ala Tyr Thr Arg 
    850                 855                 860                 


Leu Lys Ala Glu Arg Glu Thr Ala Arg Gln Thr Asn Lys Arg Leu Pro 
865                 870                 875                 880 


Pro Leu Glu Tyr Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile Ala 
                885                 890                 895     


Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met Ala 
            900                 905                 910         


Val Leu Met Leu Glu Gln Leu Met Asp Asn Ser Pro Asn Leu Arg Leu 
        915                 920                 925             


Ser Lys Ile Glu Thr Leu Leu Asn Asp Thr Thr Pro Ile Ser Glu Lys 
    930                 935                 940                 


Ile Ser Ala Lys Leu Ser Phe Asp Ala Ser Gly Glu Arg Ile Thr Asp 
945                 950                 955                 960 


Lys Ser Asn Pro Thr Ala Thr Lys Thr Leu Val Ala Glu Arg Lys Gln 
                965                 970                 975     


Lys Asn Tyr Thr Glu Leu Gln Lys Tyr Arg Tyr Asp Arg Arg Leu Pro 
            980                 985                 990         


Glu Leu Phe Glu Tyr Val Gln Ala  Asp Glu Ile Pro Leu  Glu Trp Leu 
        995                 1000                 1005             


Leu Asp  Glu Leu Ser Ala Tyr  Asn Ser Ala Lys Gln  Gln Val Phe 
    1010                 1015                 1020             


Asp Thr  Val Phe Ala Leu Glu  Lys Lys Ile Ile Gln  Thr Glu Pro 
    1025                 1030                 1035             


Asp Glu  Leu Lys Ser Leu Phe  Thr Gly Ala Asn Gly  Glu Leu Gln 
    1040                 1045                 1050             


Thr Gly  Asn Ile Gln His Lys  Pro Tyr Val Gln Trp  Leu Thr Asn 
    1055                 1060                 1065             


Lys Gly  Leu Ile Asn Lys Glu  Glu Lys Gln Phe Ile  Asn Met Val 
    1070                 1075                 1080             


Arg Lys  Cys Phe Ser His Asn  Gln Phe Pro Gln Arg  Thr Thr Met 
    1085                 1090                 1095             


Glu Leu  Leu Ile Pro Ala Trp  Asn Glu Lys Lys Leu  Ala Leu Gln 
    1100                 1105                 1110             


Ile Ala  Thr Val Tyr Asn Gln  Leu Ile Ala Asp Leu  Thr Asp Lys 
    1115                 1120                 1125             


Ile 
    


<210>  2132
<211>  1242
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2132

Met Glu Gln Asn Arg Lys Glu Gly Ser Leu Arg Thr Gln Glu Asp Ile 
1               5                   10                  15      


Gln Tyr Phe Gly Ser Tyr Phe Asn Met Ala Arg His Asn Leu Tyr Leu 
            20                  25                  30          


Ile Thr Asn His Leu Thr Ser Val Phe Ser His Leu Asn Phe Ser Gln 
        35                  40                  45              


Leu Asp Asp Asp Glu Asp Ile Trp Ser Asp Lys Pro Glu Val Asn Glu 
    50                  55                  60                  


Lys Asn Ile Leu Leu Asn Ile Phe Asp Thr Lys Asn Glu Arg Leu Gln 
65                  70                  75                  80  


Asp Glu Arg Ile Arg Val Phe Arg Tyr Leu Met Arg Arg His His Leu 
                85                  90                  95      


Pro Cys Leu Arg Ile Phe Thr Asn Asp Phe Lys Val Leu Glu Thr Thr 
            100                 105                 110         


Gly Asn Thr Ile Lys Lys Asp Glu Leu Glu Val Asp Phe Asp Ala Val 
        115                 120                 125             


His Lys Phe Leu Asn Ile Ala Phe Lys Glu Ile Asn Leu Phe Arg Asn 
    130                 135                 140                 


Ser Tyr Thr His Tyr Leu Ser Ile Asn Glu Glu Gly Lys Arg Leu Lys 
145                 150                 155                 160 


Lys Lys Lys Lys Ile Ser Ser Lys Leu Val Pro Val Leu Asn Ser Leu 
                165                 170                 175     


Phe Ser Tyr Ala Pro Glu Tyr Ser Phe Leu Arg His Asn Ile Asp Lys 
            180                 185                 190         


Ala Asn Lys Asp Val Lys Ile Tyr Lys Glu Glu Val Lys Glu Tyr Tyr 
        195                 200                 205             


Asp Asn Ile Lys Ser Lys Tyr Lys Leu Phe Glu Asn Asp Ser Asn Glu 
    210                 215                 220                 


Leu Thr Asp Gln Gly Met Tyr Phe Phe Ile Thr Leu Phe Leu Glu Arg 
225                 230                 235                 240 


Ala His Gly Ile Lys Phe Leu Lys Arg Phe Arg Gly Phe Lys Asn Glu 
                245                 250                 255     


Thr Thr Pro Pro Phe Lys Ala Thr Ile Gln Ala Phe Thr Thr Tyr Thr 
            260                 265                 270         


Leu Lys Ile Pro Asp Val Arg Leu Asp Asn Asp Ile Pro Glu Gln Thr 
        275                 280                 285             


Met Ile Met Glu Val Leu Asn Glu Leu Asn Lys Cys Pro Glu Glu Leu 
    290                 295                 300                 


Phe Lys Phe Leu Lys Lys Glu Asp Lys Asp Arg Phe Gln Pro Val Ile 
305                 310                 315                 320 


Ser Asp Glu Ser Leu Thr Asn Ile Ile Asn Ser Ser Asn Tyr Glu Glu 
                325                 330                 335     


Ile Ser Asp Glu Asp Ile Asp Arg Leu Ile Lys Glu Asn Ser Val Leu 
            340                 345                 350         


Lys Arg Arg Glu Asp Arg Phe Pro Tyr Phe Ala Leu Gln Tyr Leu Glu 
        355                 360                 365             


Ile Met Ser Lys Leu Lys Asn Ile Arg Phe Gln Ile Tyr Leu Gly Lys 
    370                 375                 380                 


Leu Val Leu Lys Thr Tyr Asp Lys Glu Asn Pro Asn Ile Glu Arg Arg 
385                 390                 395                 400 


Val Ile Thr Asp Ile His Ala Phe Gly Lys Leu Ser Asp Phe Val Gly 
                405                 410                 415     


Lys Glu Ala Glu Val Leu Asp Thr Phe Asn Ser Gln Leu Lys Asp Tyr 
            420                 425                 430         


Gly Tyr Ser Val Ala Trp Asp Gln Tyr Lys Pro Ser Tyr Ala Ile Glu 
        435                 440                 445             


Met Asn Arg Ile Gly Phe Tyr Leu Phe Asn Asp Gln Gly Asp Lys Val 
    450                 455                 460                 


Glu Asn Lys Ile Leu Pro Ser Leu Cys Lys Asn Lys Asn Leu Glu Arg 
465                 470                 475                 480 


Lys Val Glu Ile Lys Val Asn Lys Ile Gln Pro Thr Gly Phe Ile Ser 
                485                 490                 495     


Thr His Met Leu Pro Lys Phe Leu Ile Ser Tyr Leu Met Gly Asp Val 
            500                 505                 510         


Asn Glu Lys Asn Gly Glu Lys Thr Ile Thr His Phe Leu Glu Lys Val 
        515                 520                 525             


Asn Val Ser Ile Leu Asp Gln Asn Ile Ile Asn Gln Ile Lys Ser Glu 
    530                 535                 540                 


Ile Gln Asn Leu Asp Pro Ile Glu Phe Thr Lys Arg Cys Pro Lys Leu 
545                 550                 555                 560 


Ser Ala Ile Lys Asn Val Lys Lys Leu Arg Val Ala Gly Ala Ile Asp 
                565                 570                 575     


Lys Lys Ile Val Glu Tyr Gln Tyr Ile Asn Asp Thr Asp Ile Ala Lys 
            580                 585                 590         


Leu Val Gln Lys Thr Gly Leu Ala Tyr Asp Thr Met Val Thr Tyr Ser 
        595                 600                 605             


Lys Asp Lys Phe Lys Glu Lys Thr Asn His Leu Asn Leu Ser Lys Lys 
    610                 615                 620                 


Glu Leu Glu Thr Phe Ala His Ile Lys Tyr Lys Tyr Tyr Leu Ser Glu 
625                 630                 635                 640 


Arg Arg Lys Ala Leu Asp Ser Val Leu Lys Ala Tyr Phe Pro Glu Ile 
                645                 650                 655     


Gly Ser Gln Asp Ile Pro Lys Glu Leu Tyr Asn Tyr Leu Leu Asn Ile 
            660                 665                 670         


Asn Glu Gln Asp Asn Lys Lys Leu Glu His Arg Arg Ile Lys Asp Glu 
        675                 680                 685             


Val Thr Lys Thr Lys Lys Leu Ile Lys Asp Val Asn Arg Ser Leu Lys 
    690                 695                 700                 


Phe Glu Asp Lys Ile Leu Leu Gly Asp Leu Ala Thr Lys Ile Ala Arg 
705                 710                 715                 720 


Asp Ile Ile Asn Met Ile Ile Asp Lys Asp Leu Lys Val Ser Met Thr 
                725                 730                 735     


Asn Pro Phe Ala Asn Arg Leu Gln Asn Leu Ile Ala Tyr Phe Ser Thr 
            740                 745                 750         


Asn Lys Glu Ala Ile Val Ala Leu Cys Glu Ser Tyr Lys Val Phe Glu 
        755                 760                 765             


His Asn Lys Gly His Phe Phe Leu Thr Arg Glu Leu Ile Leu Asn Ser 
    770                 775                 780                 


Thr Gly Val Ile Asp Phe Tyr Ile Arg Tyr Phe Glu Ala Lys Ile Glu 
785                 790                 795                 800 


Lys Ile Lys Glu Val Leu Leu Val Arg Gly Lys Glu Gly Gly Tyr Glu 
                805                 810                 815     


Ile Asn Thr Glu Leu Ile Pro Tyr Ser Tyr Thr Gln Tyr Leu Pro Lys 
            820                 825                 830         


Glu Val Lys Glu Glu Asn Lys Asn Thr Cys Lys Asn Leu Phe Glu Gln 
        835                 840                 845             


Trp Leu Tyr Tyr Lys Gln Lys Ser Pro Val Asn Leu Pro Val Thr Leu 
    850                 855                 860                 


Leu Asp Glu Asp Leu Thr Ser Ala Leu Lys Ser Lys Leu Lys Leu Lys 
865                 870                 875                 880 


Pro Asp Leu Lys Asp Gly Phe Ser Lys Leu Ile Gln Leu Tyr Leu Lys 
                885                 890                 895     


Asp Asp Ala Gln Glu Phe Tyr Ser Phe Asp Arg Val Tyr Arg Asn Asn 
            900                 905                 910         


Asp Asn Glu His Val Ile Lys Tyr Ser Asn Glu Gly Ser Ser Lys Glu 
        915                 920                 925             


Met Gln Ile Lys Tyr Gly Lys Val Ala Val Glu Ser Glu Lys Ile Ile 
    930                 935                 940                 


Arg His Val Leu Leu Lys Asp Arg Ile Leu Arg Val Ile Cys Glu Asp 
945                 950                 955                 960 


Leu Leu Lys Ser Asp Lys Asn Thr Ser Ser Thr Lys Ser Phe Leu Leu 
                965                 970                 975     


Lys Asp Ile Ser Pro Trp Ser Glu Thr Asn Ile Leu Asn Lys Pro Asn 
            980                 985                 990         


Glu Phe Ser Tyr Asn Leu Arg Lys  Asn Ile Asp Gly Ser  Gly Thr Glu 
        995                 1000                 1005             


Tyr Cys  Thr Ile Val Ala Lys  Asp Ser Thr Glu Gln  Ile Arg Gln 
    1010                 1015                 1020             


Ile Asn  Glu Trp Asn Asp Leu  Ser Lys Glu Ile Lys  Ser Lys Phe 
    1025                 1030                 1035             


Leu Lys  Leu Asn Ala Glu Gln  Lys Ile Asp Phe Leu  Thr Thr Gln 
    1040                 1045                 1050             


Asp Glu  Lys Thr Lys Leu Val  Leu Leu Gly Gln Gln  Asn Tyr Gln 
    1055                 1060                 1065             


Trp Lys  Phe Ser Asp Phe Gly  Arg Phe Arg Arg Phe  Met Lys Asp 
    1070                 1075                 1080             


Lys Arg  Ile Asn Glu Met Val  Lys Tyr Phe Glu Pro  Lys Gln Ile 
    1085                 1090                 1095             


Pro Phe  Asp Leu Leu Glu Phe  Gln Ile Leu Gln Tyr  Asn Ile Tyr 
    1100                 1105                 1110             


Arg Glu  Lys Met Phe Asp Lys  Ile Phe Glu Leu Glu  Arg Val Met 
    1115                 1120                 1125             


Ser Glu  Arg Tyr Phe Glu Asp  Ile Lys Ser Lys His  Leu Glu Asn 
    1130                 1135                 1140             


Phe Lys  Tyr Asn Glu Val Gly  Phe Gln Thr Tyr Leu  Asn Val Leu 
    1145                 1150                 1155             


Ser Glu  Lys Ile Ala Ser Gly  Tyr Asp Ile Ala Ile  Leu Lys Trp 
    1160                 1165                 1170             


Gly Arg  Asn Lys Phe Ser His  Thr Glu Ile Val Tyr  Tyr Asn Phe 
    1175                 1180                 1185             


Ile Ser  Lys Ile Ala Val Gln  Asp Ile Glu Glu Phe  Glu Leu Lys 
    1190                 1195                 1200             


Lys His  Leu Glu Gly Tyr Lys  Glu Asn Val Ser Phe  Asn Ile Ala 
    1205                 1210                 1215             


Arg Asn  Ile Tyr Arg Val Phe  Ser Arg Glu Val Asp  Lys Thr Ile 
    1220                 1225                 1230             


Asn Leu  Ile Asn Asn Ser Phe  Lys Ile 
    1235                 1240         


<210>  2133
<211>  1171
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2133

Met Asn Leu Leu Glu Lys Thr Asn Ala Ala Glu Ser Cys Phe Asn His 
1               5                   10                  15      


Thr Ile Asn Asp Gln Lys Tyr Tyr Phe Ala Gly Tyr Leu Asn Leu Ala 
            20                  25                  30          


Gln Asn Asn Ile Lys Thr Leu Glu Lys Ala Tyr Gly Glu His Phe Leu 
        35                  40                  45              


Cys Ser Gly Asn Asn Pro Ile Ile Asn Asp Leu Thr Asn Thr Asn Ser 
    50                  55                  60                  


Leu Ile Asp Trp Asp Phe Lys Met Lys Phe Leu Ser Gln Tyr Leu Pro 
65                  70                  75                  80  


Ala Ile Ser Tyr Leu Asn Leu Glu Thr Asp Leu Asn Glu Ser Phe Glu 
                85                  90                  95      


Lys Arg Lys Lys Glu Phe Thr Lys Asn Leu Ser Phe Leu Phe Asn Ala 
            100                 105                 110         


Ile Asp Leu Leu Arg Asn Phe Tyr Ser His Tyr Tyr His Ala Pro Leu 
        115                 120                 125             


Ile Asp Glu Leu Asn Ser Glu Arg Leu Ile Phe Leu Asp Lys Ile Phe 
    130                 135                 140                 


Val Ala Val Cys Ile Asn Val Lys Lys Lys Arg Met Lys Asp Asp Lys 
145                 150                 155                 160 


Thr Lys Gln Leu Leu Lys Ala Thr Leu Ile Asp Glu Leu Asp Leu Leu 
                165                 170                 175     


Leu Lys Ala Lys Lys Glu Glu Leu Leu Lys Lys Lys Lys Glu Gly Lys 
            180                 185                 190         


Lys Val Ser Thr Asp Ala Ile Ser Met Lys Asn Ser Val Leu Asn Asp 
        195                 200                 205             


Ala Phe Asn His Leu Ile Gln Leu Glu Lys Asn Ser Lys Lys Glu Ile 
    210                 215                 220                 


Pro Gly Arg Tyr Tyr Thr Ser Leu Leu Asn Asp Asn Asn Lys Tyr Thr 
225                 230                 235                 240 


Glu Asn Gly Ile Asn Ile Ser Ile Ser Gly Leu Leu Phe Leu Leu Ser 
                245                 250                 255     


Met Phe Leu Thr Lys Lys Gln Asn Glu Asp Val Arg Ser Arg Ile Phe 
            260                 265                 270         


Gly Phe Lys Gly Thr Ile Glu Ser Asp Lys Gly Ile Ser Lys Ser Asn 
        275                 280                 285             


Asn Ser Phe Arg Asn Met Ala Thr Asn Trp Val Phe Ser Tyr Leu Ser 
    290                 295                 300                 


Phe Lys Gly Met Lys Lys Gln Leu Gly Ser Thr Phe Asn Lys Glu Ser 
305                 310                 315                 320 


Leu Leu Val Gln Ile Val Asp Glu Leu Ser Lys Val Pro His Glu Val 
                325                 330                 335     


Tyr Gln Thr Leu Ser Pro Ser Arg Gln Glu Met Phe Leu Glu Asp Met 
            340                 345                 350         


Asn Glu Tyr Leu Lys Asp Gly Asn Lys Lys His Cys Leu Glu Asp Ser 
        355                 360                 365             


Ile Val Val His Pro Val Ile Lys Lys Arg Tyr Glu Asp Lys Phe Asn 
    370                 375                 380                 


Tyr Phe Ala Ile Arg Tyr Leu Asp Glu Phe Val Asp Phe Pro Ser Leu 
385                 390                 395                 400 


Arg Phe Gln Val Asn Val Gly Asn Tyr Val His Asp Arg Arg Lys Lys 
                405                 410                 415     


Thr Ile Asp Gly Thr Asn Thr Glu Thr Asp Arg Met Val Lys Glu Glu 
            420                 425                 430         


Ile Arg Ala Phe Gly Lys Leu Ser Phe Ile Ser Lys Leu Lys Ala Asp 
        435                 440                 445             


Tyr Phe Ala Lys Asp Leu Pro Ser Asp Ile Ser Trp Glu Met Tyr Pro 
    450                 455                 460                 


Asn Pro Ser Tyr Asn Phe Ser Ala Asn Asn Ile Pro Val Tyr Ile Asp 
465                 470                 475                 480 


Leu Phe Lys Ser Ser Val Ala Gly Ala Ala Asp Val Gly Lys Asp His 
                485                 490                 495     


Lys Gly Tyr Gln Ala Lys Leu Asp Leu Asp Glu Asp Gly Lys Lys Arg 
            500                 505                 510         


Asn Arg Asn Glu Gly Lys Pro Asp Lys Lys Glu Ile Ala Glu Ile Leu 
        515                 520                 525             


Phe Gly Lys Lys Asn Lys Gln Ile Leu Phe Glu Lys Pro Thr Val Leu 
    530                 535                 540                 


Leu Ser Leu Asn Glu Leu Pro Ala Met Leu Tyr Glu Val Leu Ile Glu 
545                 550                 555                 560 


Asn Gly Asp Lys Gln Asp Ile Gly Lys Arg Ile Glu Asp Lys Ile Val 
                565                 570                 575     


Glu Lys Ile Ile Ala His Tyr Asn Leu Leu Asp Gln Tyr Asp Gly Thr 
            580                 585                 590         


Thr Glu Leu Pro Gly Ser Val Ile Pro Arg Lys Leu Arg Met Gly Gly 
        595                 600                 605             


Asn Glu Lys Ser Ile Asn Ile Asp Lys Leu Leu Arg Ala Val Lys Arg 
    610                 615                 620                 


Glu Leu Glu Ile Thr Gln Glu Lys Leu Asp Leu Ile Lys Thr Asn Gln 
625                 630                 635                 640 


Lys Lys Phe Lys Ser Lys Glu Lys Asp Glu Lys Gly Asn Ser Arg Gln 
                645                 650                 655     


His Val Phe Tyr Thr Asn Glu Leu Gly Gln Glu Ala Thr Trp Ile Ala 
            660                 665                 670         


Asn Asp Met Lys Arg Phe Met Pro Lys Glu Val Lys Glu Lys Trp Arg 
        675                 680                 685             


Gly Tyr His His Ser Asn Leu Gln Lys Leu Leu Ala Leu Tyr Asp Gln 
    690                 695                 700                 


Thr Arg Asn Glu Ala Val Lys Cys Ile Thr Cys Phe Trp Asn Phe Asp 
705                 710                 715                 720 


Gln Gln Thr Ser Trp Gly Lys Gly Ile Lys Glu Ala Phe Tyr Lys Ser 
                725                 730                 735     


Thr Phe Glu Glu Phe Tyr Lys Ala Tyr Leu Glu His Arg Met Asp Val 
            740                 745                 750         


Tyr Lys Thr Leu Glu Asn Asn Leu Ile Ala Gly Lys Gly Tyr Ser Lys 
        755                 760                 765             


Leu Phe Asn Lys Glu Lys Lys Lys Ala Phe Ile Leu Phe Asp Glu His 
    770                 775                 780                 


Leu Tyr Thr Ile Pro Asp Ile Asn Thr Gln Lys Glu Arg Leu Lys Ser 
785                 790                 795                 800 


Thr Leu Phe Ile Leu Pro Arg Gly Ile Phe Asp Ser Lys Pro Thr Phe 
                805                 810                 815     


Ile Lys Gly Ile Lys Tyr Glu Glu Asp Pro Ser Cys Phe Ala Asp Trp 
            820                 825                 830         


Tyr Gln Phe Ala Asn Ala Thr Gly Asn Gln Tyr Gln Arg Phe Tyr Asp 
        835                 840                 845             


Leu Pro Arg Ser Tyr Thr Ser Leu Phe Glu Glu Thr Lys Lys Asn Asn 
    850                 855                 860                 


Glu Gly Leu Ile Glu Asn Lys Lys Gly Leu Ser Ala Lys Glu Gln Leu 
865                 870                 875                 880 


Asp Phe Phe Lys Met Arg Gln Asp Leu Lys Ile Lys Lys Ile Lys Thr 
                885                 890                 895     


Gln Asp Leu Phe Leu Phe Met Ile Val Arg Asp Leu Tyr Lys Lys Val 
            900                 905                 910         


Phe Asp His Thr Leu Pro Leu Glu Ile Gly Leu Arg Asp Met Tyr Gln 
        915                 920                 925             


Thr Pro Ala Glu Arg Gln Ala Asn Tyr Asp Leu Ala Val Lys Gln Ser 
    930                 935                 940                 


Gln Arg Thr Glu Gly Asp Asn Ser Asp Asn Leu Tyr Asn Tyr Asn Phe 
945                 950                 955                 960 


Leu Trp Asn Leu Thr Ile Pro Phe Glu Tyr Asp Lys Ile Lys Glu Pro 
                965                 970                 975     


Gln Val Lys Leu Lys Asp Val Gly Lys Phe Tyr Lys Phe Ala Ala Asp 
            980                 985                 990         


Glu Lys Val Gln Thr Ile Leu Ser  Tyr Ser Asp Arg Glu  Trp Ser Lys 
        995                 1000                 1005             


Leu Asp  Leu Glu Lys Glu Leu  Glu Leu Met Pro Thr  Ser Tyr Glu 
    1010                 1015                 1020             


Val Ile  Arg Arg Glu Gln Leu  Leu Arg Asp Ile Gln  Gln Phe Glu 
    1025                 1030                 1035             


Lys Arg  Ile Leu Glu Asn Tyr  Pro Ser Asp Gly Asn  Ala His Pro 
    1040                 1045                 1050             


Ala Asp  Leu Glu Lys Glu Asp  Lys Asp Lys Lys Cys  Phe Pro Asn 
    1055                 1060                 1065             


Phe Asn  Leu Tyr Leu Leu Lys  Gly Ile Ile Ile Lys  Asn Asn Leu 
    1070                 1075                 1080             


Ala Ser  Glu Glu Glu Arg Gln  Trp Phe Glu Gln Val  His Leu Asp 
    1085                 1090                 1095             


Lys Thr  Pro Phe Tyr Pro Glu  Val Glu Thr Lys Ser  Ser Ile Ile 
    1100                 1105                 1110             


Gln Ser  Ala Tyr Leu Leu Leu  Leu Ile Arg Asn Lys  Met Leu His 
    1115                 1120                 1125             


Asn Gln  Leu Pro Ser Lys Gln  Asn Phe Glu Phe Met  Thr Thr Leu 
    1130                 1135                 1140             


Tyr Pro  Phe Glu Gly Tyr Glu  Ser Tyr Ser Thr Tyr  Leu Leu Phe 
    1145                 1150                 1155             


Val Thr  Lys Lys Thr Ile Glu  Cys Leu Ser Ser Ala  Met 
    1160                 1165                 1170     


<210>  2134
<211>  1043
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2134

Met Glu Asn Lys Glu Gln Asn Lys Arg Thr Trp Asp Asn Asp Pro Gln 
1               5                   10                  15      


Tyr Phe Gly Ser Tyr Leu Asn Met Ala Arg Leu Asn Ile Phe Asn Ile 
            20                  25                  30          


Ser Asn His Leu Ala Lys Lys Phe Gly Leu Thr Val Leu Glu Asp Glu 
        35                  40                  45              


Gly Lys Ile Thr Ile Ser Phe Leu Gly Asp Lys Glu Asn Lys Lys Tyr 
    50                  55                  60                  


Lys Thr Lys Gln Gly Leu Ile Tyr Ser Asn Leu Thr Arg Tyr Met Pro 
65                  70                  75                  80  


Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Glu Asn Glu Arg Asn 
                85                  90                  95      


Lys Val Lys Asn Asn Phe Gly Lys Asp Phe Asn Arg Leu Ser Asp Thr 
            100                 105                 110         


Leu Lys Ile Val Phe Lys Glu Leu Asn Glu Phe Arg Asn Asp Tyr Ser 
        115                 120                 125             


His Tyr Tyr Ser Thr Glu Lys Gln Asp Lys Arg Lys Leu Glu Ile Ser 
    130                 135                 140                 


Ser Glu Leu Asn Asp Phe Leu Ile Leu Asn Phe Ser Arg Ala Leu Ser 
145                 150                 155                 160 


Tyr Thr Lys Glu Arg Phe Lys Asp Val Phe Ser Asp Glu Asp Phe Lys 
                165                 170                 175     


Ile Ala Ser Gln Thr Ile Val Val Asn Asn Asp Lys Thr Ile Thr Gln 
            180                 185                 190         


Asp Gly Ile Val Phe Leu Thr Ser Met Phe Leu Asp Arg Glu Asn Ala 
        195                 200                 205             


Phe Arg Phe Ile Asn Lys Ile Ile Gly Leu Lys Gly Thr Gln Thr Asn 
    210                 215                 220                 


Glu Phe Lys Ala Lys Arg Glu Val Leu Leu Phe Phe Cys Val Lys Leu 
225                 230                 235                 240 


Pro His Asp Lys Phe Val Ser Glu Asn Thr Glu Leu Ala Phe Ser Leu 
                245                 250                 255     


Asp Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu Tyr Asn Val 
            260                 265                 270         


Ile Thr Glu Glu Gly Lys Gln Leu Phe Arg Pro Thr Leu Glu Thr Glu 
        275                 280                 285             


Gln Ile Lys Asn Val Leu Gln Asn Ser Val Pro Asp Thr Ile Asp Asp 
    290                 295                 300                 


Tyr Glu Asn Tyr Ile Glu Gly Ile Thr Lys Lys Val Arg Asn Glu Asn 
305                 310                 315                 320 


Arg Phe Ser Tyr Phe Ala Leu Lys Tyr Ile Asp Gln Lys Glu Leu Phe 
                325                 330                 335     


Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val Leu Asp Glu 
            340                 345                 350         


Tyr Tyr Lys Gln Leu Asn Gly Lys Asp Glu Val Arg Thr Val Thr Glu 
        355                 360                 365             


Asn Ala Lys Ala Phe Gly Arg Leu Gln Asp Leu Asn Asp Glu Glu Asn 
    370                 375                 380                 


Thr Leu Lys Lys Ile Asn Thr Gly Glu Asn Lys Thr Cys Phe Asp Gln 
385                 390                 395                 400 


Phe Ala Pro His Tyr Asn Phe Asp Asp Lys Asn Asn Lys Ile Gly Ile 
                405                 410                 415     


Ser Lys Lys Glu Ile Thr Ser Arg Phe Ile Ser Gln Lys Thr Asp Lys 
            420                 425                 430         


Lys Val Lys Phe Asn Leu Leu Gln Pro Leu Pro Glu Ala Phe Leu Ser 
        435                 440                 445             


Ile His Glu Leu Ser Lys Ile Ile Leu Leu Glu Tyr Leu Glu Gln Gly 
    450                 455                 460                 


Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn Asn Ala Lys 
465                 470                 475                 480 


Ile Ile Asn Arg Glu Phe Ile Glu Thr Ile Lys Ser Lys Leu Ser Glu 
                485                 490                 495     


Phe Asn Val Phe His Lys Arg Ser Gln Gly Arg Lys Glu Lys Arg Ala 
            500                 505                 510         


Tyr Ser Glu Gly Ala Leu Lys Tyr Leu Leu Glu Arg Lys Glu Lys Leu 
        515                 520                 525             


Asn Gln Ile Leu Ala Glu His Asn Leu Asn Val Lys Gln Ile Pro Ala 
    530                 535                 540                 


Arg Ile Leu Asp Tyr Trp Leu Asn Ile Glu Asp Val Gln Glu Lys Thr 
545                 550                 555                 560 


Ala Ile Ser Gly Arg Ile Lys Leu Met Lys Arg Asp Cys Met Asp Arg 
                565                 570                 575     


Leu Lys Ala Ile Lys Lys Lys Asn Pro Pro Lys Ile Gly Glu Met Ala 
            580                 585                 590         


Thr Phe Leu Ala Lys Asp Val Val Asp Met Ile Ile Ser Glu Glu Lys 
        595                 600                 605             


Lys Lys Lys Ile Thr Ser Phe Tyr Tyr Asp Lys Ile Gln Glu Cys Leu 
    610                 615                 620                 


Ala Leu Phe Ala Asp Lys Glu Lys Lys Glu Leu Phe Ile Gln Ile Cys 
625                 630                 635                 640 


Asn Glu Leu Lys Leu Asn Asn Glu Ser Asp Gly His Pro Phe Leu Lys 
                645                 650                 655     


Asn Ile Asn Leu Asn Glu Phe Arg Tyr Thr Ser Asp Leu Tyr Lys Lys 
            660                 665                 670         


Tyr Ala Glu Glu Lys Arg Leu Tyr Leu Glu Asn Asn Phe Tyr Lys Lys 
        675                 680                 685             


Glu Arg Asn Glu Lys Ala Lys Lys Asp Leu Thr Val Val Val Leu Pro 
    690                 695                 700                 


His Asp Lys Ser Lys Ile Pro Phe Ser Ile Arg Gln Leu Glu Lys Glu 
705                 710                 715                 720 


Lys Thr Ser Phe Asp Lys Trp Leu Glu Tyr Val Thr Lys Gly Lys Glu 
                725                 730                 735     


Thr Thr Asp Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp 
            740                 745                 750         


Asp Thr Leu Lys Arg Leu Leu Lys Thr Glu Leu Ser Lys Asn Asn Ile 
        755                 760                 765             


Glu Phe Asp Asn Asp Ala Asn Asn Asn Glu Leu Phe Lys Thr Trp Trp 
    770                 775                 780                 


Ser Gln Cys Arg Glu Asp Asp Val Gln Lys Phe Tyr Thr Ala Glu Arg 
785                 790                 795                 800 


Glu Tyr Thr Phe Glu Lys Gly Lys Leu Thr Phe Lys Ile Asn Ser Lys 
                805                 810                 815     


Ser Lys Phe Glu Glu Tyr Ile Asp Gln Glu Phe Ile Glu Asn Val Phe 
            820                 825                 830         


Lys Ser Lys Ser Arg Lys Arg Glu Asn Glu Asn Asn Thr Gly Arg Lys 
        835                 840                 845             


Leu Pro Pro Leu Arg Ile Lys Glu Val Thr Lys Asn Ile Val Lys Lys 
    850                 855                 860                 


Ile Gly Asn Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg 
865                 870                 875                 880 


Leu Met Leu Leu Met Phe Glu Gln Leu Thr Lys Lys Glu Leu Asn Val 
                885                 890                 895     


Lys Leu Lys Asn Ala Asp Asp Leu Leu Asn Glu Gln Ile Glu Ile Arg 
            900                 905                 910         


Glu Asn Ile Ser Gly Lys Leu Val Phe Asp Glu Phe Gly His Leu Ile 
        915                 920                 925             


Glu Glu Lys Lys Ser Gln Lys Thr Ile Ala Lys Asn Ile Val Glu Thr 
    930                 935                 940                 


Arg Lys Arg Lys Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Lys 
945                 950                 955                 960 


Arg Leu Pro Glu Leu Phe Glu Tyr Phe Glu Glu Glu Asp Ile Pro Met 
                965                 970                 975     


Glu Lys Ile Lys Leu Glu Leu Asp Ser Tyr Thr Lys Ala Lys Asp Ile 
            980                 985                 990         


Ile Phe Asp Leu Ala Phe Lys Leu  Glu Glu Thr Ile Ile  Lys Lys Asp 
        995                 1000                 1005             


Glu Ser  Gly Ile Lys Glu Leu  Asn Lys Asp Pro Glu  Gly Asn Ile 
    1010                 1015                 1020             


Gln Ser  Gly Asn Ile Gln His  Lys Pro Tyr Leu His  Trp Leu Leu 
    1025                 1030                 1035             


Lys Asn  Asp Leu Ile 
    1040             


<210>  2135
<211>  1119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2135

Met Thr Glu Gln Asn Glu Arg Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Phe Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Ala His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Lys Tyr Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Gly Thr Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Thr Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Ser Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Leu Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Asp Glu Ala 
            500                 505                 510         


Ser Ala Glu Met Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Asp Glu Ile Asn Thr Arg Asp 
    530                 535                 540                 


Glu Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Gly Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Leu Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asn Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Leu Ala Lys Leu Lys Lys Glu Ile Leu Glu Ala 
        835                 840                 845             


Lys Glu His Pro Tyr Leu Asp Phe Lys Ser Trp Gln Lys Phe Glu Arg 
    850                 855                 860                 


Glu Leu Arg Leu Val Lys Asn Gln Asp Ile Ile Thr Trp Met Met Cys 
865                 870                 875                 880 


Arg Asp Leu Met Glu Glu Asn Lys Val Glu Gly Leu Asp Thr Gly Thr 
                885                 890                 895     


Leu Tyr Leu Lys Asp Ile Arg Thr Glu Val Gln Glu Gln Gly Ser Leu 
            900                 905                 910         


Asn Val Leu Asn Arg Val Lys Pro Met Arg Leu Pro Val Val Val Tyr 
        915                 920                 925             


Arg Ala Asp Ser Arg Gly His Val His Lys Glu Gln Ala Pro Leu Ala 
    930                 935                 940                 


Thr Val Tyr Ile Glu Glu Arg Asp Thr Lys Leu Leu Lys Gln Gly Asn 
945                 950                 955                 960 


Phe Lys Ser Phe Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe 
                965                 970                 975     


Val Asn Thr Gly Ala Leu Ala Met Glu Gln Tyr Pro Ile Ser Lys Leu 
            980                 985                 990         


Arg Val Glu Tyr Glu Leu Ala Lys  Tyr Gln Thr Ala Arg  Val Cys Ala 
        995                 1000                 1005             


Phe Glu  Gln Thr Leu Glu Leu  Glu Glu Ser Leu Leu  Thr Arg Tyr 
    1010                 1015                 1020             


Pro His  Leu Pro Asp Lys Asn  Phe Arg Lys Met Leu  Glu Ser Trp 
    1025                 1030                 1035             


Ser Asp  Pro Leu Leu Asp Lys  Trp Pro Asp Leu His  Arg Lys Val 
    1040                 1045                 1050             


Arg Leu  Leu Ile Ala Val Arg  Asn Ala Phe Ser His  Asn Gln Tyr 
    1055                 1060                 1065             


Pro Met  Tyr Asp Glu Ala Val  Phe Ser Ser Ile Arg  Lys Tyr Asp 
    1070                 1075                 1080             


Pro Ser  Ser Pro Asp Ala Ile  Glu Glu Arg Met Gly  Leu Asn Ile 
    1085                 1090                 1095             


Ala His  Arg Leu Ser Glu Glu  Val Lys Gln Ala Lys  Glu Met Ala 
    1100                 1105                 1110             


Glu Arg  Ile Ile Gln Ala 
    1115                 


<210>  2136
<211>  1312
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2136

Met Gly Lys Gly Asn Lys Gly Asn Glu Val Lys Ile Gln Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Arg Ile Gln Lys Thr Asn Phe Thr Ile Ser Leu Thr Gly 
            20                  25                  30          


Lys His Val Phe Gly Ala Tyr Phe Asn Met Ala Arg Thr Asn Phe Ile 
        35                  40                  45              


Lys Thr Ile Asn Tyr Ile Leu Pro Ile Ala Gly Val Arg Gly Asn Tyr 
    50                  55                  60                  


Ser Glu Asn Gln Ile Asn Asn Met Leu His Ala Leu Phe Leu Ile His 
65                  70                  75                  80  


Ala Gly Arg Asn Ser Glu Leu Ser Lys Glu Gln Lys Gln Trp Glu Lys 
                85                  90                  95      


Lys Leu Arg Leu Asn Leu Glu Gln Gln Thr Lys Leu Gln Lys Leu Leu 
            100                 105                 110         


Phe Lys His Phe Pro Val Leu Gly Pro Met Met Ala Asp Val Ala Asp 
        115                 120                 125             


His Lys Ala Phe Leu Asn Lys Lys Lys Ser Lys Val Gln Thr Glu Asp 
    130                 135                 140                 


Glu Ala Phe Val Gln Leu Lys Gly Val Ser Leu Ser Asp Cys Leu Glu 
145                 150                 155                 160 


Met Ile His Leu Met Ala Ile Thr Leu Thr Glu Cys Arg Asn Phe Tyr 
                165                 170                 175     


Thr His Lys Ser Pro Tyr Asn Thr Pro Ser Gln Leu Ala Ser Gln Tyr 
            180                 185                 190         


Gln His Gln Glu Gln Ile Ala Lys Lys Leu Asp Lys Val Val Val Ala 
        195                 200                 205             


Ser Arg Arg Ile Leu Lys Asp Arg Glu Gly Leu Ser Ile Asn Glu Val 
    210                 215                 220                 


Glu Phe Leu Thr Gly Ile Asp His Leu His Gln Glu Ile Glu Lys Asp 
225                 230                 235                 240 


Gln Phe Gly Asn Ile Val Lys Lys Asn Gly Lys Val Leu Lys Thr Phe 
                245                 250                 255     


Val Glu Tyr Asp Asp Phe Tyr Phe Lys Ile Phe Gly Lys Arg Leu Val 
            260                 265                 270         


Lys Gly Leu Thr Val Ala Val Lys Asp Asn Asp Pro Val Asn Val Asp 
        275                 280                 285             


Thr Met Leu Pro Ala Leu Ser Asp Phe Gly Leu Leu Tyr Phe Cys Val 
    290                 295                 300                 


Leu Phe Leu Ser Lys Pro Tyr Ala Lys Leu Phe Ile Asp Glu Thr Arg 
305                 310                 315                 320 


Leu Phe Glu Phe Ser Pro Phe Asn Asp Asn Glu Asn Met Ile Leu Ser 
                325                 330                 335     


Glu Met Leu Ser Ile Tyr Arg Ile Arg Thr Pro Arg Leu His Lys Ile 
            340                 345                 350         


Asp Ser Arg Asp Asn Lys Ala Ala Leu Ala Met Asp Ile Phe Gly Glu 
        355                 360                 365             


Leu Arg Cys Cys Pro Ile Glu Leu Tyr Asp Leu Leu Asp Lys Asn Thr 
    370                 375                 380                 


Gly Gln Ser Phe Phe His Asp Glu Val Lys Arg Pro Asn Ser His Thr 
385                 390                 395                 400 


Pro Glu Val Ser Lys Arg Leu Arg Tyr Asp Asp Arg Phe Pro Thr Leu 
                405                 410                 415     


Ala Leu Arg Tyr Ile Asp Glu Thr Glu Leu Phe Lys Arg Ile Arg Phe 
            420                 425                 430         


Gln Ile Gln Leu Gly Ala Phe Arg Tyr Arg Phe Phe Asp Lys Glu Asp 
        435                 440                 445             


Cys Ile Asp Gly Arg Val Arg Val Arg Ser Ile Gln Lys Glu Ile Asn 
    450                 455                 460                 


Gly Tyr Gly Arg Leu Gln Glu Val Ala Asp Lys Arg Leu Glu Lys Trp 
465                 470                 475                 480 


Gly Asp Met Leu Gln Lys Arg Glu Glu Arg Ser Val Lys Leu Glu His 
                485                 490                 495     


Glu Glu Leu Tyr Leu Asp Leu Asp Gln Phe Gln Glu Asp Thr Ala Asn 
            500                 505                 510         


Ser Thr Pro Tyr Val Thr Asp Arg Arg Pro Ser Tyr Asn Ile His Ala 
        515                 520                 525             


Asn Arg Ile Gly Leu Tyr Trp Glu Asp Ser Gln Asn Pro Lys Gln Phe 
    530                 535                 540                 


Lys Val Phe Asp Glu Asn Gly Met Tyr Ile Pro Lys Leu Ile Val Thr 
545                 550                 555                 560 


Glu Asp Glu Lys Ala Pro Ile Asn Met Pro Ala Pro Arg Cys Ala Leu 
                565                 570                 575     


Ser Val Tyr Asp Leu Pro Ala Met Leu Phe Tyr Glu Tyr Leu Arg Glu 
            580                 585                 590         


Gln Gln Lys Gly Asn Val Gln Ala Ala Glu Gln Ile Ile Ile Asp Tyr 
        595                 600                 605             


Glu Asn Asp Tyr Arg Lys Phe Phe Lys Ala Val Ala Glu Gly Thr Leu 
    610                 615                 620                 


Lys Pro Phe Gln Lys Thr Lys Glu Leu Arg Glu Tyr Leu Glu Glu Asn 
625                 630                 635                 640 


Tyr Pro Lys Leu Arg Met Ser Asp Ile Pro Glu Lys Ile Gln Leu Tyr 
                645                 650                 655     


Leu Thr Ser Lys Gly Leu Thr His Asn Asn Lys Pro Glu Thr Val Arg 
            660                 665                 670         


Glu Arg Met Ile Arg Leu Ile Asn Gln His Leu Glu Glu Arg Glu Lys 
        675                 680                 685             


Asn Val Gln Arg Arg Leu Glu His Tyr Gln Glu Asp Arg Lys Met Val 
    690                 695                 700                 


Gly Glu Lys Glu Asn Lys Tyr Gly Lys Lys Gly Phe Ala Asp Val Arg 
705                 710                 715                 720 


His Gly Ala Leu Ala Arg Tyr Leu Thr Gln Ser Met Met Glu Trp Gln 
                725                 730                 735     


Pro Ser Lys Asp Gly Lys Gly Tyr Asp Lys Leu Thr Gly Leu Asn Tyr 
            740                 745                 750         


Asn Val Leu Thr Ala Tyr Leu Ala Thr Phe Gly Thr Pro Gln Thr Val 
        755                 760                 765             


Glu Glu Gly Phe Thr Pro Lys Ser Leu Glu Gln Val Leu Thr Lys Ala 
    770                 775                 780                 


His Ile Ile Gly Gly Ser Asn Pro His Pro Phe Met Asn Lys Val Leu 
785                 790                 795                 800 


Ser Leu Gly Ser Arg Asn Ile Glu Glu Leu Tyr Leu His Tyr Leu Glu 
                805                 810                 815     


Glu Glu Leu Lys His Ile Arg Ser Arg Lys Gln Ser Leu Ser Ser Asn 
            820                 825                 830         


Ser Ser Asp Lys Ala Leu Ser Ser Leu Pro Phe Val His His Asp Arg 
        835                 840                 845             


Met Arg Phe His Glu Arg Thr Asp Glu Glu Met Arg Ala Leu Ala Ala 
    850                 855                 860                 


Arg Tyr Thr Thr Ile Gln Leu Pro Asp Gly Leu Phe Thr Pro Phe Ile 
865                 870                 875                 880 


Val Glu Ile Leu Gln Gln His Tyr Ser Asp Asn Asn Glu Leu Gln Thr 
                885                 890                 895     


Ala Leu Lys Gln Asp Ile Pro Ala Lys Leu Asn Pro Thr His Asn Ala 
            900                 905                 910         


Ala Tyr Leu Ile Thr Gln Phe Tyr Gln Thr Val Leu Lys Asp Asp Ala 
        915                 920                 925             


Gln Pro Phe Tyr Leu Ser Ser Lys Thr Tyr Thr Arg Thr Lys Glu Gly 
    930                 935                 940                 


Glu Asp Pro Lys Thr Phe Ser Phe Lys Lys Thr Tyr Glu Leu Phe Ser 
945                 950                 955                 960 


Val Leu Asn Asn Asp Lys Lys Asp Ser Phe Pro Tyr Glu Leu Ile Pro 
                965                 970                 975     


Leu Phe Leu Thr Ser Asp Glu Ile Gln Glu Arg Leu Ser Ala Lys Leu 
            980                 985                 990         


Leu Asp Glu Asn Gly Asn Pro Ile  Pro Glu Ala Gly Lys  Lys Gly Lys 
        995                 1000                 1005             


Pro Ala  Thr Asp Ser Gln Gly  Asn Val Ile Trp Gln  Arg Ile Ile 
    1010                 1015                 1020             


Lys Gln  Glu Ile Lys Asn His  Val Glu Ser Leu Ser  Asp Lys Asp 
    1025                 1030                 1035             


Leu Lys  Ile Ser Met Asn Gln  Ser Trp Lys Gln Lys  Asn Glu Glu 
    1040                 1045                 1050             


Arg Ala  Ala Lys Arg Glu Ala  Met Gln Ser Arg Leu  Ile Arg Gln 
    1055                 1060                 1065             


Ile Asn  Glu Val Lys Asp Asn  Glu Arg Leu Leu Arg  Arg Tyr Lys 
    1070                 1075                 1080             


Thr Gln  Asp Met Val Leu Phe  Leu Met Ala Lys Lys  Met Phe Ala 
    1085                 1090                 1095             


Asn Ile  Ile Ser Glu Gln Gly  Asn Glu Val Asn Trp  Lys Gln Met 
    1100                 1105                 1110             


Arg Leu  Ser Lys Val Cys Asn  Glu Ala Phe Leu Arg  Gln Thr Leu 
    1115                 1120                 1125             


Thr Phe  Arg Val Pro Val Ala  Val Gly Glu Lys Thr  Val Tyr Val 
    1130                 1135                 1140             


Glu Gln  Glu Asn Met Ser Leu  Lys Asn Tyr Gly Glu  Phe Tyr Arg 
    1145                 1150                 1155             


Phe Leu  Thr Asp Asp Arg Leu  Thr Ser Leu Leu Glu  Asn Ile Val 
    1160                 1165                 1170             


Glu Thr  Leu Lys Pro Asn Lys  Asp Gly Asp Leu Val  Ile Arg His 
    1175                 1180                 1185             


Thr Asp  Leu Met Ser Glu Leu  Ala Ala Tyr Asp Gln  Ile Arg Ser 
    1190                 1195                 1200             


Thr Ile  Phe Glu Leu Ile Gln  Lys Ile Glu Asp Ile  Ile Ile Glu 
    1205                 1210                 1215             


Lys Lys  Lys Asp Leu Lys Asp  Pro Asn Ser Asp Met  Phe Trp Ala 
    1220                 1225                 1230             


His Glu  Gly Leu Pro Lys Leu  Asn Asn Phe Ala Ser  Leu Leu Glu 
    1235                 1240                 1245             


Leu Ile  Asp Arg Leu Asn Asp  Met Ala Leu Thr Asp  Asp Glu Arg 
    1250                 1255                 1260             


Arg Leu  Leu Val Ala Ile Arg  Asn Ala Phe Ser His  Asn Ser Tyr 
    1265                 1270                 1275             


Asn Ile  Asp Phe Ser Leu Ile  Lys Thr Ile Lys His  Leu Pro Glu 
    1280                 1285                 1290             


Val Ala  Lys Gly Ile Leu Gln  His Leu Gln Ser Val  Leu Gly Val 
    1295                 1300                 1305             


Glu Gln  Ile Gln 
    1310         


<210>  2137
<211>  1009
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (375)..(375)
<223>  Xaa can be any naturally occurring amino acid

<400>  2137

Met Asp Thr Pro Asn Phe Ser Glu Arg Ile Pro Val Ser Leu Gln Ser 
1               5                   10                  15      


His Pro Tyr Tyr Phe Ala His Tyr Leu Asn Met Ala Arg His Asn Ala 
            20                  25                  30          


Tyr Val Ile Leu Glu Tyr Val Asn Arg Glu Leu Ile Lys Pro Gly Lys 
        35                  40                  45              


Asn Leu Asp Glu Asp Asn Leu Ile Gln Ser Thr Val Leu Lys Asp Gly 
    50                  55                  60                  


Tyr Phe Asp Arg Lys Pro Asp Glu Leu Ser His Arg Asn Arg Leu Leu 
65                  70                  75                  80  


Val Gln His Phe Pro Phe Leu Arg Glu Ala Glu Asn Glu Gly Ala Arg 
                85                  90                  95      


Thr Cys Asn Pro Val Ser Tyr Lys Leu Lys Thr Ala Leu Ala Ala Leu 
            100                 105                 110         


Asn Gln Trp Arg Asn Asn Ala Ser His Tyr Pro Leu Asn Gln Asn His 
        115                 120                 125             


Glu Lys Asp Phe Asp Leu Gln Pro Phe Phe Ser Phe Ala Ile Glu Ala 
    130                 135                 140                 


Cys Lys Lys Arg Met Arg Glu Val Phe Gln Pro Asp Asp Phe Tyr Leu 
145                 150                 155                 160 


Leu Glu Thr Asn Glu Lys Gln Phe Tyr Thr Leu His Asn Glu Asn Gly 
                165                 170                 175     


Phe Thr Glu Lys Gly Leu Tyr Cys Phe Ile Cys Phe Phe Leu Glu Lys 
            180                 185                 190         


Lys Tyr Ala Phe Gln Phe Leu Ala Gly Ile Lys Gly Phe Lys Asn Thr 
        195                 200                 205             


Thr Asp Asn Lys Phe Arg Ala Thr Leu Glu Thr Phe Thr Glu His Cys 
    210                 215                 220                 


Cys Arg Leu Pro Lys Pro Lys Leu Asp Ser Ser Asp Ile Lys Leu Asp 
225                 230                 235                 240 


Met Leu Gly Glu Leu Ser Arg Cys Pro Ala Pro Leu Phe Asp Leu Leu 
                245                 250                 255     


Asp Ile Glu Glu Arg Lys Lys Phe Ile Arg Glu Pro Glu Glu Val Lys 
            260                 265                 270         


Pro Asp Glu Ser Gly Asp Arg Glu Glu Val Gln Gln Val Leu Met Lys 
        275                 280                 285             


Arg Tyr Asp Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Glu Glu 
    290                 295                 300                 


Lys Asn Leu Leu Lys Gly Ile Ser Phe His Ile His Ile Gly Arg Trp 
305                 310                 315                 320 


Ile Lys Ser Glu His Thr Lys Lys Ile Met Gly Ala Glu Arg Asp Arg 
                325                 330                 335     


Arg Leu Leu Lys Asp Ile Arg Thr Phe Gly Glu Leu Lys Glu Phe Ser 
            340                 345                 350         


Pro Glu His Ala Pro Asp Tyr Trp Leu Arg Asp Gly Ile Thr Pro Asp 
        355                 360                 365             


Asp Val Asp Gln Phe Ser Xaa Pro Gln Tyr Arg Ile Val Gly Asn Arg 
    370                 375                 380                 


Ile Gly Ile Lys Leu Asn Tyr Asn Gly His Asn Arg Trp Ser Val Pro 
385                 390                 395                 400 


Asp Lys Glu Ile Asn Val Lys Pro Asp Ala Ile Ile Ser Thr Tyr Glu 
                405                 410                 415     


Phe Leu Asn Leu Phe Leu Tyr Glu His Leu Tyr Gln Lys Lys Leu Thr 
            420                 425                 430         


Gly Leu Ser Pro Ala Glu Phe Ile Gln Asp Tyr Leu Asp Arg Phe Asn 
        435                 440                 445             


Asn Phe Leu Ser Glu Phe Lys Ala Gly His Ile Arg Pro Val Gly Asp 
    450                 455                 460                 


Phe Ser Leu Glu Lys Arg Arg Gly Gln Gly Asp Glu Pro Asp Leu Thr 
465                 470                 475                 480 


Ala Arg Arg Lys Ser Leu Gln Lys Glu Leu Asp Arg Phe Val Leu Lys 
                485                 490                 495     


Gly Lys Asp Leu Pro Asp Lys Ile Arg Glu Tyr Leu Leu Gly Tyr Lys 
            500                 505                 510         


Gln Lys Ser Glu Lys Lys Gln Ala Lys Trp Ile Leu Gly Gly Met Ile 
        515                 520                 525             


Lys Glu Thr Val Tyr Trp Arg Asn Lys Ala Glu Gln Ser Pro Glu Lys 
    530                 535                 540                 


Met Arg Ser Gly Asp Met Ala Gln Gln Leu Ala Arg Asp Ile Ile Phe 
545                 550                 555                 560 


Leu Thr Pro Pro His Thr Val Lys Glu His Lys Gln Lys Leu Asn Ser 
                565                 570                 575     


Leu Glu Tyr Asp Val Leu Gln Tyr Ala Leu Ala Tyr Phe Ser Ser Asn 
            580                 585                 590         


Arg Glu Lys Leu Tyr Ser Phe Phe Lys Glu His Gln Leu Thr Val Lys 
        595                 600                 605             


Gly Asp Arg Ala His Pro Phe Leu Tyr Lys Ile Arg Leu Asp Glu Cys 
    610                 615                 620                 


Gln Gly Ile Leu Asp Phe Phe Ile Val Tyr Met Gln Gln Lys Glu Lys 
625                 630                 635                 640 


Trp Leu Gly Trp Leu Asp Arg Asn Leu Lys Ser Pro Arg Leu Asn Glu 
                645                 650                 655     


Glu Glu Phe Phe Asn Thr Tyr Ser Tyr Phe Ile Lys Thr Asp Thr Lys 
            660                 665                 670         


Arg Ala Ile Glu Met Asp Tyr Glu Ser Cys Pro Asn Tyr Leu Pro Arg 
        675                 680                 685             


Gly Ile Phe Asn Glu Pro Ile Ala Lys Ala Val Gln Lys Ala Gly Val 
    690                 695                 700                 


Lys Ile Lys Asp Glu Asp Asn Ala Ser Tyr Ala Leu Ser Val Tyr Ser 
705                 710                 715                 720 


Asn Gly Lys Thr Gln Pro Phe Tyr Asn Lys Glu Arg Tyr Tyr Asn Lys 
                725                 730                 735     


Gly Ile Phe Arg Met Glu Glu Leu Pro Glu Lys Leu Gln Pro Lys Glu 
            740                 745                 750         


Leu Leu Gly Lys Ile Gln Trp Thr Ile Lys Ser Ser Gly Lys Asp Thr 
        755                 760                 765             


Glu Glu Phe Arg Ser Leu Gln Asn Leu Lys Asn Arg Ile Leu Asn Thr 
    770                 775                 780                 


Glu Lys Glu Ile Arg Tyr Val Gln Ser Thr Asp Arg Ala Leu Trp Ile 
785                 790                 795                 800 


Met Val Ala Asp Leu Phe Pro Glu Thr Phe Glu Leu Arg Pro Asp Asp 
                805                 810                 815     


Leu Glu Cys Ile Gly His Asp Leu Ser Asp Asp Leu Leu Ser Arg Pro 
            820                 825                 830         


Tyr Gln Met Lys Glu Lys Val Tyr Asn Tyr Thr Ile Thr Asp Tyr Leu 
        835                 840                 845             


Pro Ile Lys Arg Tyr Gly Glu Phe Arg Arg Phe Leu Lys Asp Arg Arg 
    850                 855                 860                 


Leu Glu Asn Leu Leu Thr Tyr Phe Glu Glu Gly Val Pro Leu His Arg 
865                 870                 875                 880 


Glu Ala Leu Val Ala Glu Leu Glu Ala Tyr Asp Leu Gln Arg Lys Asn 
                885                 890                 895     


Leu Leu Glu Ile Ile Tyr Arg Phe Glu Lys Leu Val Phe Asp Arg His 
            900                 905                 910         


Arg His Glu Leu Thr Phe Ser Gly Glu Gly Glu Asn Gln Tyr Val Asn 
        915                 920                 925             


His Trp Asp Tyr Leu Asp Phe Val Ala Arg Lys Tyr Gly Leu Ser Ala 
    930                 935                 940                 


Glu Val Lys Glu Leu Asn Ser Glu Arg Phe Thr Glu Leu Arg Asn Lys 
945                 950                 955                 960 


Met Leu His Asn Gln Ile Pro Tyr Gln Leu Trp Ile Lys Glu Ala Ile 
                965                 970                 975     


Ala Ala Arg Glu Glu Asn Thr Val Cys Gly Arg Ile Met Gly Met Ile 
            980                 985                 990         


Gly Glu Ile Tyr Glu Arg Met Thr  Thr Glu Ile Glu Lys  Gln Met Gln 
        995                 1000                 1005             


Val 
    


<210>  2138
<211>  1146
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2138

Met Glu Ser Ile Ile Gly Leu Gly Leu Ser Phe Asn Pro Tyr Lys Thr 
1               5                   10                  15      


Ala Asp Lys His Tyr Phe Gly Ser Phe Leu Asn Leu Ala Asp Asn Asn 
            20                  25                  30          


Leu Lys Ala Val Phe Ala Glu Phe Lys Glu Arg Ile Ser Asp Lys Ser 
        35                  40                  45              


Lys Asp Glu Asp Ile Ser Asn Leu Ile Glu Lys His Phe Ile Asp Asn 
    50                  55                  60                  


Met Ser Ile Val Asp Tyr Glu Lys Asn Ile Ser Ile Leu Asn Gly Tyr 
65                  70                  75                  80  


Leu Pro Ile Ile Asp Phe Leu Asp Asp Glu Leu Glu Asn Asn Leu Asn 
                85                  90                  95      


Thr Arg Val Lys Asn Phe Lys Lys Ser Phe Ile Ile Leu Ala Glu Ala 
            100                 105                 110         


Leu Glu Thr Leu Arg Asn Tyr Tyr Thr His Phe Tyr His Asp Pro Ile 
        115                 120                 125             


Thr Phe Gly Asp Asn Lys Glu Pro Leu Leu Glu Leu Leu Asp Glu Val 
    130                 135                 140                 


Leu Leu Lys Thr Ile Leu Asp Val Lys Lys Lys Tyr Leu Lys Thr Asp 
145                 150                 155                 160 


Lys Thr Lys Glu Ile Leu Lys Asp Ser Leu Arg Glu Glu Met Asp Leu 
                165                 170                 175     


Leu Val Ile Arg Lys Thr Asp Glu Leu Arg Glu Lys Lys Lys Thr Asn 
            180                 185                 190         


Pro Lys Phe Lys Phe Ser Thr Asp Pro Thr Gln Ile Arg Asn Ser Ile 
        195                 200                 205             


Phe Asn Asp Ala Phe Gln Gly Leu Leu Tyr Glu Asp Lys Glu Asn Asn 
    210                 215                 220                 


Gly Lys Thr Gln Val Ser His Arg Ala Lys Thr Lys Leu Asn Pro Lys 
225                 230                 235                 240 


Asp Ile His Lys Gln Glu Glu Arg Asp Phe Glu Ile Pro Leu Ser Thr 
                245                 250                 255     


Ser Gly Ile Val Phe Leu Met Ser Leu Phe Leu Ser Lys Lys Glu Ile 
            260                 265                 270         


Glu Asp Phe Lys Ser Asn Ile Lys Gly Phe Lys Gly Lys Val Val Lys 
        275                 280                 285             


Asp Glu Asn His Asn Ser Leu Lys Tyr Met Ala Thr His Arg Val Tyr 
    290                 295                 300                 


Ser Ile Leu Ala Phe Lys Gly Leu Lys Tyr Arg Ile Lys Thr Asp Thr 
305                 310                 315                 320 


Phe Ser Lys Val Thr Leu Met Met Gln Met Ile Asp Glu Leu Ser Lys 
                325                 330                 335     


Val Pro Asp Cys Val Tyr Gln Asn Leu Ser Glu Thr Lys Gln Lys Asp 
            340                 345                 350         


Phe Ile Glu Asp Trp Asn Glu Tyr Leu Lys Asp Asn Glu Glu Asn Thr 
        355                 360                 365             


Glu Asn Leu Glu Asn Ser Arg Val Val His Pro Leu Ile Arg Lys Arg 
    370                 375                 380                 


Tyr Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe 
385                 390                 395                 400 


Ala Asn Phe Lys Thr Leu Lys Phe Gln Val Phe Met Gly Tyr Tyr Ile 
                405                 410                 415     


His Asp Gln Arg Thr Lys Thr Ile Gly Thr Thr Asn Ile Thr Thr Glu 
            420                 425                 430         


Arg Thr Val Lys Glu Lys Ile Asn Val Phe Gly Lys Leu Ser Lys Met 
        435                 440                 445             


Asp Asn Leu Lys Lys His Phe Phe Ser Gln Leu Ser Asp Glu Glu Asn 
    450                 455                 460                 


Thr Asp Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Phe Leu Thr Gln 
465                 470                 475                 480 


Ala Asp Asn Ser Pro Ala Asn Asn Ile Pro Ile Tyr Leu Glu Leu Lys 
                485                 490                 495     


Asn Gln Gln Ile Ile Lys Glu Lys Asp Asp Ile Lys Ala Glu Val Asn 
            500                 505                 510         


Asn Ser Gln Asn Arg Asn Pro Asn Lys Pro Ser Lys Arg Asp Leu Leu 
        515                 520                 525             


Asn Lys Ile Ser Asn Thr Asn Glu Asp Phe Tyr Gln Gly Asp Pro Thr 
    530                 535                 540                 


Ala Ile Leu Ser Leu Asn Glu Ile Pro Ala Leu Leu His Leu Phe Leu 
545                 550                 555                 560 


Val Gln Pro Asp Asn Lys Thr Gly Gln Gln Ile Glu Asn Ile Ile Arg 
                565                 570                 575     


Ile Lys Ile Glu Lys Gln Phe Asn Ser Ile Lys Asn Pro Ser Lys Asp 
            580                 585                 590         


Asp Lys Gly Val Pro Lys Ser Leu Phe Ala Asp Thr Asn Val Arg Val 
        595                 600                 605             


Asn Ala Ile Lys Leu Lys Lys Asp Leu Gly Glu Glu Leu Asp Met Leu 
    610                 615                 620                 


Asn Lys Lys Gln Ile Val Phe Lys Glu Asn Gln Lys Ala Ser Ser Asn 
625                 630                 635                 640 


Tyr Asp Glu Leu Leu Lys Lys His Gln Phe Thr Pro Lys Asn Lys Arg 
                645                 650                 655     


Pro Ala Leu Arg Lys Tyr Val Phe Tyr Asn Ser Glu Lys Gly Glu Glu 
            660                 665                 670         


Ala Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Lys Gly Phe 
        675                 680                 685             


Lys Thr Lys Trp Lys Gly Tyr Gln His Ser Glu Leu Gln Arg Lys Leu 
    690                 695                 700                 


Ala Phe Tyr Asp Arg His Thr Lys Gln Asp Ile Lys Glu Leu Leu Ser 
705                 710                 715                 720 


Gly Cys Glu Phe Asp His Phe Leu Leu Asp Ile Asn Ala Cys Phe Lys 
                725                 730                 735     


Glu Asp Asp Phe Glu Asp Phe Phe Ser Lys Tyr Leu Lys Asn Arg Ile 
            740                 745                 750         


Glu Thr Leu Asn Ile Ile Leu Lys Gln Leu His Asp Phe Lys Asn Glu 
        755                 760                 765             


Pro Thr Pro Leu Lys Gly Val Phe Lys Asn Cys Leu Lys Phe Leu Lys 
    770                 775                 780                 


Gln Lys Asn Tyr Val Thr Glu Asn Pro Glu Ile Ile Lys Lys Arg Ile 
785                 790                 795                 800 


Leu Ala Lys Pro Ala Phe Leu Pro Arg Gly Ile Phe Asp Glu Arg Pro 
                805                 810                 815     


Thr Met Lys Lys Gly Lys Asn Pro Leu Ile Asp Arg Asp Glu Phe Ala 
            820                 825                 830         


Lys Trp Phe Val Glu Tyr Leu Glu Asn Lys Asp Tyr Gln Lys Phe Tyr 
        835                 840                 845             


Asn Ser Glu Glu Tyr Arg Ile Arg Asp Ala Asp Phe Lys Lys Asn Ala 
    850                 855                 860                 


Val Ile Lys Lys Gln Lys Leu Lys Asp Phe Tyr Thr Leu Gln Met Val 
865                 870                 875                 880 


Asn Tyr Leu Leu Lys Glu Val Phe Gly Lys Asp Glu Met Asn Leu Gln 
                885                 890                 895     


Leu Ser Glu Leu Phe Gln Thr Arg Gln Glu Arg Leu Lys Leu Gln Gly 
            900                 905                 910         


Ile Ala Lys Lys Gln Met Asn Lys Glu Thr Gly Asp Ser Ser Glu Asn 
        915                 920                 925             


Thr Arg Asn Gln Thr Tyr Ile Trp Asn Lys Asp Val Pro Val Ser Phe 
    930                 935                 940                 


Phe Asn Gly Lys Val Thr Ile Asp Lys Val Lys Leu Lys Asn Ile Gly 
945                 950                 955                 960 


Lys Tyr Lys Arg Tyr Glu Arg Asp Glu Arg Val Lys Thr Phe Ile Gly 
                965                 970                 975     


Tyr Glu Val Asp Glu Lys Trp Met Met Tyr Leu Pro His Asn Trp Lys 
            980                 985                 990         


Asp Arg Tyr Ser Val Lys Pro Ile  Asn Val Ile Asp Leu  Gln Ile Gln 
        995                 1000                 1005             


Glu Tyr  Glu Glu Ile Arg Ser  His Glu Leu Leu Lys  Glu Ile Gln 
    1010                 1015                 1020             


Asn Leu  Glu Gln Tyr Ile Tyr  Asp His Thr Thr Asp  Lys Asn Thr 
    1025                 1030                 1035             


Leu Leu  Gln Asp Gly Asn Pro  Asn Phe Lys Met Tyr  Val Leu Asn 
    1040                 1045                 1050             


Gly Leu  Leu Thr Gly Ile Lys  Gln Val Asn Ile Ala  Asp Phe Ile 
    1055                 1060                 1065             


Val Leu  Lys Gln Asn Thr Asn  Phe Asp Lys Ile Asp  Phe Thr Gly 
    1070                 1075                 1080             


Ile Ala  Ser Cys Ser Glu Leu  Glu Lys Lys Thr Ile  Ile Leu Ile 
    1085                 1090                 1095             


Ala Ile  Arg Asn Lys Phe Ala  His Asn Gln Leu Pro  Asn Lys Thr 
    1100                 1105                 1110             


Ile Tyr  Asp Leu Ala Asn Glu  Phe Leu Lys Lys Glu  Lys Arg Glu 
    1115                 1120                 1125             


Thr Tyr  Ala Asn Tyr Tyr Leu  Lys Val Leu Lys Lys  Met Ile Ser 
    1130                 1135                 1140             


Asp Leu  Ala 
    1145     


<210>  2139
<211>  1142
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2139

Met Asp Gln Leu Ile Asn Gln Thr Met Val Ala Ser Phe Lys Lys Ile 
1               5                   10                  15      


Phe Asp His Lys Gly Tyr Ile Ala Pro Ile Val Asn Lys Ala Trp Asp 
            20                  25                  30          


Asn Phe Asn Val Ile Asn Lys Asn Ser Val Asn Lys Val Glu Asp Val 
        35                  40                  45              


Tyr His Phe Ala Val Gly His Val Phe Lys Asn Leu Asn Lys Lys Leu 
    50                  55                  60                  


Ile Phe Glu Tyr Arg Leu Asn Glu Val Ser Arg Gln Met Glu Ser Ser 
65                  70                  75                  80  


Lys Phe Thr Ser Leu Asp Lys Asn Asn Phe Asn Phe Cys Asp Thr Leu 
                85                  90                  95      


Trp Ser Val Val Asn Asn Ile Arg Asn Leu Asn Ser His Tyr Val His 
            100                 105                 110         


Thr Phe Asp Glu Val Gly Leu Asn Lys Ile Lys Lys Thr Glu Thr Val 
        115                 120                 125             


Thr Phe Leu Lys Glu Ala Phe Glu Leu Ser Ser Ile Phe Ala Phe Ile 
    130                 135                 140                 


Asn Glu Gln Asn Gln Thr Leu Glu Glu Tyr Ile Asn Asp Glu Asn Arg 
145                 150                 155                 160 


Asp Lys Lys Leu Val Arg Phe Trp Lys Glu Lys Phe Phe Pro Asn Glu 
                165                 170                 175     


Glu His Gln Lys Ala Glu Arg Ala Ile Leu Asp Gly Tyr Thr Lys Gly 
            180                 185                 190         


Gln Ala Leu Asp Tyr Leu Leu Phe Ile Ser Val Pro Asn Asp Phe Glu 
        195                 200                 205             


Trp Thr Ile Ala Asp Thr His Pro Val Phe Thr Ile Lys Ala Gly Ser 
    210                 215                 220                 


Tyr Leu Ser Phe His Ala Gln Leu Phe Leu Ile Ser Ile Phe Leu Tyr 
225                 230                 235                 240 


Lys His Glu Ala Glu Gln Leu Ile Ser Lys Ile Lys Gly Phe Lys Lys 
                245                 250                 255     


Asn Asp Asp Ile Tyr Asn Arg Lys Arg Asn Ile Phe Thr Phe Phe Ser 
            260                 265                 270         


Lys Lys Phe Ser Ser Arg Asp Ala Asp Thr Glu Gln Lys His Leu Ile 
        275                 280                 285             


Leu Phe Arg Asp Ile Val Gln Tyr Leu Asn His Tyr Pro Thr Glu Trp 
    290                 295                 300                 


Asn Glu Ala Leu Arg Arg Glu Thr Pro Val Pro Ala Met Thr Ala Gln 
305                 310                 315                 320 


Leu Glu Arg His Ile Ile Lys Thr Glu Ile Tyr Arg Ala Phe Pro Asp 
                325                 330                 335     


Tyr Glu Gly Asn Pro Thr Phe Leu Tyr Phe Ala Gly Lys His Phe Phe 
            340                 345                 350         


Gly Lys Lys Phe Leu Thr Tyr Phe Pro Glu Ala Ala Asp Glu Phe Thr 
        355                 360                 365             


Ala Lys Glu Lys Ser Asp Phe Leu Tyr Glu Ile Asn Ala Ser Leu Ala 
    370                 375                 380                 


Leu Lys Asp Ile Asn Ser Lys Thr Ala Arg Leu Asn His Lys Ala Arg 
385                 390                 395                 400 


Leu Thr Arg Thr Glu Glu Lys Glu Lys Asp Lys Leu Lys Lys Asp Lys 
                405                 410                 415     


Ile Lys Glu Glu Lys Lys Pro Asn Pro Val Lys Glu Lys Leu Gln Lys 
            420                 425                 430         


Arg Ile Asp Asp Asn Met Leu Phe Val Ser Tyr Gly Arg Asn Val Asp 
        435                 440                 445             


Arg Phe Met Glu Phe Ala Ile Arg Phe Leu Ala Glu Glu Asn Tyr Phe 
    450                 455                 460                 


Gly Lys Asp Ala Leu Phe Asn Met Tyr Lys Phe Tyr Thr Ser Asp Glu 
465                 470                 475                 480 


Gln Asp Arg Tyr Leu Arg Glu Ile Lys Pro Val Val Ser Lys Lys Glu 
                485                 490                 495     


Tyr Asp Asn Gln Ser Tyr His Gln Gly Lys Leu Thr Glu Phe Leu Thr 
            500                 505                 510         


Tyr Glu Lys Tyr Leu Ser Lys Tyr Pro Gln Trp Asp Asp Pro Phe Val 
        515                 520                 525             


Ile Arg Asp Asn Ala Phe Gln Val Lys Val Cys Phe Asp Val Asn Asn 
    530                 535                 540                 


Phe Lys Ile Phe Ser Val Gln Arg Ser Leu Leu Ile Tyr Leu Leu Glu 
545                 550                 555                 560 


Asp Ala Leu Phe Asn Tyr Asp Asn Asp Lys Lys Lys Arg Glu Asp Ala 
                565                 570                 575     


Gly Lys Arg Leu Leu Arg Asp Tyr Phe Cys Glu Phe Lys Lys Asp Phe 
            580                 585                 590         


Asp Ser Gly Leu Gln Thr Leu Thr Val Asn Glu Thr Val Thr Ala Thr 
        595                 600                 605             


Glu Lys Thr Gly Leu Met Lys Leu Phe Pro Lys Arg Leu Leu His Arg 
    610                 615                 620                 


Tyr Ser Pro Ala Val Pro Asn Tyr Val Pro Glu Tyr Gly Ser Val Met 
625                 630                 635                 640 


Asp Arg Ile Leu Ala Glu Thr Val Asp Lys Glu Glu Arg Tyr Ala Ala 
                645                 650                 655     


Leu Leu Ala Lys Ala Arg Ser Glu Gly Arg Glu Glu Asp Phe Leu Lys 
            660                 665                 670         


Tyr Asn Lys Gly Lys Gln Phe Lys Leu Arg Phe Leu Lys Lys Ala Trp 
        675                 680                 685             


His Ile Leu Tyr Phe Lys Asn Ile Tyr Leu Gln Arg Ala Gly Val Ala 
    690                 695                 700                 


Gly His His Lys Asp Phe His Ile Thr Lys Glu Glu Phe Asn Asp Phe 
705                 710                 715                 720 


Cys Lys Trp Ile Phe Ala Phe Asp Glu Val Pro Gln Tyr Lys Thr Tyr 
                725                 730                 735     


Leu Ala Gly Tyr Phe Thr Ala Lys His Phe Phe Asp Asn Asp Ala Phe 
            740                 745                 750         


Lys Lys Leu Phe Thr Glu Ser Asp Ser Leu Gln Ser Leu Tyr Asp Asn 
        755                 760                 765             


Thr Lys Gln Ala Phe Glu Glu Phe Ala Lys Ser Ala Gln Gln Gln Ile 
    770                 775                 780                 


Ala Pro Asp Lys Tyr Arg Leu Glu Asn Tyr Glu Gln Phe Phe Lys Lys 
785                 790                 795                 800 


Ala Val Val Tyr Ile Asn Leu Ser His Phe Ile Glu Trp Leu Gln Ala 
                805                 810                 815     


Lys Ser Arg Leu Gln Lys Asn Ala Gln Gly Gln Leu Gln Tyr Arg Ser 
            820                 825                 830         


Ala Glu Asn Lys Gln Tyr Leu His Glu Asp Phe Tyr Tyr Lys Asp Thr 
        835                 840                 845             


Leu Pro Val Asp Glu Tyr Lys Lys His Gly Lys Leu Phe Asn Lys Leu 
    850                 855                 860                 


Lys Lys Ala Lys Leu Glu Asp Cys Leu Leu Tyr Glu Thr Ala Leu His 
865                 870                 875                 880 


Tyr Leu Gly Leu Lys Arg Asn Val Ile Ser Gln Ala Arg Thr His Ile 
                885                 890                 895     


Ser Glu Met Leu Thr Gln Asp Ile Glu Phe Asp Ile Lys Lys Lys Asp 
            900                 905                 910         


Gly Glu His Leu Tyr Lys Leu Met Val Pro Phe Asn Lys Ile Asp Ser 
        915                 920                 925             


Leu Ala Arg Leu Val Arg Lys Thr Glu Glu Gln Leu Gln Glu Phe Lys 
    930                 935                 940                 


Ser Ser Phe Met Glu Asn Ile Val Leu Tyr Leu Ala Glu Val Glu Asp 
945                 950                 955                 960 


Gln Lys Asp Ile Lys Thr Phe Tyr Glu Lys Phe Arg Asn Ser Asn Ile 
                965                 970                 975     


Leu Thr Phe Glu Asn Leu His Ile Leu Asn Asn Asn Val Ile Lys Gly 
            980                 985                 990         


Ala Ile Lys Phe Thr Arg Val Cys  Met Leu Leu Glu Met  Tyr Phe Ile 
        995                 1000                 1005             


Val Lys  His Arg Ile Arg Val  Thr His Ser Asn Arg  Ile Asp Ile 
    1010                 1015                 1020             


Lys Gly  Ile Lys Asp Thr Ala  Gly Arg Ala Glu Val  Pro Lys Tyr 
    1025                 1030                 1035             


Ala Cys  Glu Cys Tyr Arg Lys  Lys Ala Phe His Phe  Gly Val Pro 
    1040                 1045                 1050             


Asp Lys  Asp Phe Val Lys Val  Leu Glu Asn Thr Glu  Arg Met Phe 
    1055                 1060                 1065             


Leu Asp  Asn Glu Ile Lys Pro  Gln Gln Leu Gln Ser  Trp Asp Asp 
    1070                 1075                 1080             


Leu Gln  Pro Leu Gln Lys Thr  Ile Cys Ser Gln Phe  Met Asp Met 
    1085                 1090                 1095             


Leu His  Gly Ser Leu Tyr Lys  Arg Glu Lys Ser Pro  His Gly Ser 
    1100                 1105                 1110             


Gly Ser  Ser Glu Glu Gly Ser  Glu Arg Ala Lys Arg  Glu Met Gln 
    1115                 1120                 1125             


Ala Phe  Arg Glu Ala Tyr Phe  Arg Lys Met Ile Val  Gly Lys 
    1130                 1135                 1140         


<210>  2140
<211>  1146
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2140

Met Glu Ser Ile Ile Gly Leu Gly Leu Ser Phe Asn Pro Tyr Lys Thr 
1               5                   10                  15      


Ala Asp Lys His Tyr Phe Gly Ser Phe Leu Asn Leu Ala Asp Asn Asn 
            20                  25                  30          


Leu Lys Ala Val Phe Ala Glu Phe Lys Glu Arg Ile Ser Asp Lys Ser 
        35                  40                  45              


Lys Asp Glu Asp Ile Ser Asn Leu Ile Glu Lys His Phe Ile Asp Asn 
    50                  55                  60                  


Met Ser Ile Val Asp Tyr Glu Lys Asn Ile Ser Ile Leu Asn Gly Tyr 
65                  70                  75                  80  


Leu Pro Ile Ile Asp Phe Leu Asp Asp Glu Leu Glu Asn Asn Leu Asn 
                85                  90                  95      


Thr Arg Val Lys Asn Phe Lys Lys Ser Phe Ile Ile Leu Ala Glu Ala 
            100                 105                 110         


Leu Glu Thr Leu Arg Asn Tyr Tyr Thr His Phe Tyr His Asp Pro Ile 
        115                 120                 125             


Thr Phe Gly Asp Asn Lys Glu Pro Leu Leu Glu Leu Leu Asp Glu Val 
    130                 135                 140                 


Leu Leu Lys Thr Ile Leu Asp Val Lys Lys Lys Tyr Leu Lys Thr Asp 
145                 150                 155                 160 


Lys Thr Lys Glu Ile Leu Lys Asp Ser Leu Arg Glu Glu Met Asp Leu 
                165                 170                 175     


Leu Val Ile Arg Lys Thr Asp Glu Leu Arg Glu Lys Lys Lys Thr Asn 
            180                 185                 190         


Pro Lys Phe Lys Phe Ser Thr Asp Pro Thr Gln Ile Arg Asn Ser Ile 
        195                 200                 205             


Phe Asn Asp Ala Phe Gln Gly Leu Leu Tyr Glu Asp Lys Glu Asn Asn 
    210                 215                 220                 


Gly Lys Thr Gln Val Ser Tyr Arg Ala Lys Thr Lys Leu Asn Pro Lys 
225                 230                 235                 240 


Asp Ile His Lys Gln Glu Glu Arg Asp Phe Glu Ile Pro Leu Ser Thr 
                245                 250                 255     


Ser Gly Ile Val Phe Leu Met Ser Leu Phe Leu Ser Lys Lys Glu Ile 
            260                 265                 270         


Glu Asp Phe Lys Ser Asn Ile Lys Gly Phe Lys Gly Lys Val Val Lys 
        275                 280                 285             


Asp Glu Asn His Asn Ser Leu Lys Tyr Met Ala Thr His Arg Val Tyr 
    290                 295                 300                 


Ser Ile Leu Ala Phe Lys Gly Leu Lys Tyr Arg Ile Lys Thr Asp Thr 
305                 310                 315                 320 


Phe Ser Lys Val Thr Leu Met Met Gln Met Ile Asp Glu Leu Ser Lys 
                325                 330                 335     


Val Pro Asp Cys Val Tyr Gln Asn Leu Ser Glu Thr Lys Gln Lys Asp 
            340                 345                 350         


Phe Ile Glu Asp Trp Asn Glu Tyr Leu Lys Asp Asn Glu Glu Asn Thr 
        355                 360                 365             


Glu Asn Leu Glu Asn Ser Arg Val Val His Pro Leu Ile Arg Lys Arg 
    370                 375                 380                 


Tyr Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe 
385                 390                 395                 400 


Ala Asn Phe Lys Thr Leu Lys Phe Gln Val Phe Met Gly Tyr Tyr Ile 
                405                 410                 415     


His Asp Gln Arg Thr Lys Thr Ile Gly Thr Thr Asn Ile Thr Thr Glu 
            420                 425                 430         


Arg Thr Val Lys Glu Lys Ile Asn Val Phe Gly Lys Leu Ser Lys Met 
        435                 440                 445             


Asp Asn Leu Lys Lys His Phe Phe Ser Gln Leu Ser Asp Glu Glu Asn 
    450                 455                 460                 


Thr Asp Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Phe Leu Thr Gln 
465                 470                 475                 480 


Ala Asp Asn Ser Pro Ala Asn Asn Ile Pro Ile Tyr Leu Glu Leu Lys 
                485                 490                 495     


Asn Gln Gln Ile Ile Lys Glu Lys Asp Asp Ile Lys Ala Glu Val Asn 
            500                 505                 510         


Asn Ser Gln Asn Arg Asn Pro Asn Lys Pro Ser Lys Arg Asp Leu Leu 
        515                 520                 525             


Asn Lys Ile Ser Asn Thr Asn Glu Asp Phe Tyr Gln Gly Asp Pro Thr 
    530                 535                 540                 


Ala Ile Leu Ser Leu Asn Glu Ile Pro Ala Leu Leu His Leu Phe Leu 
545                 550                 555                 560 


Val Gln Pro Asp Asn Lys Thr Gly Gln Gln Ile Glu Asn Ile Ile Arg 
                565                 570                 575     


Ile Lys Ile Glu Lys Gln Phe Asn Ser Ile Lys Asn Pro Ser Lys Asp 
            580                 585                 590         


Asp Lys Gly Val Pro Lys Ser Leu Phe Ala Asp Thr Asn Val Arg Val 
        595                 600                 605             


Asn Ala Ile Lys Leu Lys Lys Asp Leu Gly Glu Glu Leu Asp Met Leu 
    610                 615                 620                 


Asn Lys Lys Gln Ile Val Phe Lys Glu Asn Gln Lys Ala Ser Ser Asn 
625                 630                 635                 640 


Tyr Asp Glu Leu Leu Lys Lys His Gln Phe Thr Pro Lys Asn Lys Arg 
                645                 650                 655     


Pro Ala Leu Arg Lys Tyr Val Phe Tyr Asn Ser Glu Lys Gly Glu Glu 
            660                 665                 670         


Ala Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Lys Gly Phe 
        675                 680                 685             


Lys Thr Lys Trp Lys Gly Tyr Gln His Ser Glu Leu Gln Arg Lys Leu 
    690                 695                 700                 


Ala Phe Tyr Asp Arg His Thr Lys Gln Asp Ile Lys Glu Leu Leu Ser 
705                 710                 715                 720 


Gly Cys Glu Phe Asp His Phe Leu Leu Asp Ile Asn Ala Cys Phe Lys 
                725                 730                 735     


Glu Asp Asp Phe Glu Asp Phe Phe Ser Lys Tyr Leu Lys Asn Arg Ile 
            740                 745                 750         


Glu Thr Leu Asn Ile Ile Leu Lys Gln Leu His Asp Phe Lys Asn Glu 
        755                 760                 765             


Pro Thr Pro Leu Lys Gly Val Phe Lys Asn Cys Leu Lys Phe Leu Lys 
    770                 775                 780                 


Gln Lys Asn Tyr Val Thr Glu Asn Pro Glu Ile Ile Lys Lys Arg Ile 
785                 790                 795                 800 


Leu Ala Lys Pro Ala Phe Leu Pro Arg Gly Ile Phe Asp Glu Arg Pro 
                805                 810                 815     


Thr Met Lys Lys Gly Lys Asn Pro Leu Ile Asp Arg Asp Glu Phe Ala 
            820                 825                 830         


Lys Trp Phe Val Glu Tyr Leu Glu Asn Lys Asp Tyr Gln Lys Phe Tyr 
        835                 840                 845             


Asn Ser Glu Glu Tyr Arg Ile Arg Asp Ala Asp Phe Lys Lys Asn Ala 
    850                 855                 860                 


Val Ile Lys Lys Gln Lys Leu Lys Asp Phe Tyr Thr Leu Gln Met Val 
865                 870                 875                 880 


Asn Tyr Leu Leu Lys Glu Val Phe Gly Lys Asp Glu Met Asn Leu Gln 
                885                 890                 895     


Leu Ser Glu Leu Phe Gln Thr Arg Gln Glu Arg Leu Lys Leu Gln Gly 
            900                 905                 910         


Ile Ala Lys Lys Gln Met Asn Lys Glu Thr Gly Asp Ser Ser Glu Asn 
        915                 920                 925             


Thr Arg Asn Gln Thr Tyr Ile Trp Asn Lys Asp Val Pro Val Ser Phe 
    930                 935                 940                 


Phe Asn Gly Lys Val Thr Ile Asp Lys Val Lys Leu Lys Asn Ile Gly 
945                 950                 955                 960 


Lys Tyr Lys Arg Tyr Glu Arg Asp Glu Arg Val Lys Thr Phe Ile Gly 
                965                 970                 975     


Tyr Glu Val Asp Glu Lys Trp Met Met Tyr Leu Pro His Asn Trp Lys 
            980                 985                 990         


Asp Arg Tyr Ser Val Lys Pro Ile  Asn Val Ile Asp Leu  Gln Ile Gln 
        995                 1000                 1005             


Glu Tyr  Glu Glu Ile Arg Ser  His Glu Leu Leu Lys  Glu Ile Gln 
    1010                 1015                 1020             


Asn Leu  Glu Gln Tyr Ile Tyr  Asp His Thr Thr Asp  Lys Asn Thr 
    1025                 1030                 1035             


Leu Leu  Gln Asp Gly Asn Pro  Asn Phe Lys Met Tyr  Val Leu Asn 
    1040                 1045                 1050             


Gly Leu  Leu Thr Gly Ile Lys  Gln Val Asn Ile Ala  Asp Phe Ile 
    1055                 1060                 1065             


Val Leu  Lys Gln Asn Thr Asn  Phe Asp Lys Ile Asp  Phe Thr Gly 
    1070                 1075                 1080             


Ile Ala  Ser Cys Ser Glu Leu  Glu Lys Lys Thr Ile  Ile Leu Ile 
    1085                 1090                 1095             


Ala Ile  Arg Asn Lys Phe Ala  His Asn Gln Leu Pro  Asn Lys Thr 
    1100                 1105                 1110             


Ile Tyr  Asp Leu Ala Asn Glu  Phe Leu Lys Lys Glu  Lys Arg Glu 
    1115                 1120                 1125             


Thr Tyr  Ala Asn Tyr Tyr Leu  Lys Val Leu Lys Lys  Met Ile Ser 
    1130                 1135                 1140             


Asp Leu  Ala 
    1145     


<210>  2141
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2141

Met Glu Thr Lys Gln Gln Val Gly Lys Gly Ile Ser Tyr Asp His Arg 
1               5                   10                  15      


Arg Pro Asp Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asp Gly Val Ile Gln Glu Phe Ala Met Arg Leu Asn Arg 
        35                  40                  45              


Glu Tyr Asp Pro Glu Asn Lys Asn Gln Ser Leu Phe Ser Tyr Phe Asn 
    50                  55                  60                  


Ile Asn Ala Ser Phe Thr Asp Trp Glu Arg Gly Val Asn Ile Leu Lys 
65                  70                  75                  80  


Glu Tyr Trp Pro Met Met Glu Phe Ile Asp Arg Pro Ala Thr Asp Lys 
                85                  90                  95      


Gln Phe Glu Ala Glu Lys Pro Glu Asn Arg Glu Ala Ala Lys Arg Lys 
            100                 105                 110         


Tyr Phe Leu Ala Thr Leu Gly Ala Leu Leu Thr Ser Ile Lys Asp Leu 
        115                 120                 125             


Arg His Tyr Tyr Thr His Tyr Tyr His Pro Pro Val His Leu Asn Asp 
    130                 135                 140                 


Asp Leu Phe Leu Phe Leu Asp His Ala Leu Leu Tyr Thr Ala Phe Asp 
145                 150                 155                 160 


Val Lys Lys Thr Lys Met Lys Asp Asp Lys Thr Arg Gln Leu Leu Asn 
                165                 170                 175     


Gln Asn Leu Ser Leu Glu Leu Glu Lys Leu Lys Lys Leu Lys Val Glu 
            180                 185                 190         


Glu Leu Lys Lys Lys Lys Glu Lys Gly Ile Lys Val Asn Leu Gln Asp 
        195                 200                 205             


Glu Lys Gly Ile Leu Asn Ala Ile Tyr Asn Asp Ala Phe Ala His Ile 
    210                 215                 220                 


Ile Thr Lys Glu Lys Asp Ser Asp Lys Asp Lys Leu Glu Thr Arg Tyr 
225                 230                 235                 240 


Lys Ser Ile Leu Pro Gln Asp Glu Ala Ala Glu Thr Gly Ile Asn Ile 
                245                 250                 255     


Ser Ile Ser Gly Leu Ile Phe Leu Leu Ser Leu Phe Leu Ser Arg Lys 
            260                 265                 270         


Glu Ile Glu Gln Leu Lys Ser Asn Ile Glu Gly Tyr Lys Gly Lys Val 
        275                 280                 285             


Leu Asn Ile Glu Thr Glu Val Asp Arg Lys His Asn Ser Leu Lys Tyr 
    290                 295                 300                 


Met Ala Thr His Trp Val Phe Ser Ile Leu Ala Phe Lys Gly Leu Lys 
305                 310                 315                 320 


Gln Arg Leu Thr Asn Ser Phe Glu Lys Glu Ser Leu Leu Ile Gln Met 
                325                 330                 335     


Met Asp Glu Leu Asn Lys Val Pro Asp Glu Leu Tyr Gln Thr Leu Ser 
            340                 345                 350         


Glu Thr Ala Lys Lys Glu Phe Leu Glu Asp Ile Asn Glu Tyr Val Ser 
        355                 360                 365             


Glu Gly Asp Asp Asn Glu Lys Ala Thr Tyr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Ser Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gln Phe Pro Thr Leu Lys Phe Gln Ile Phe Val Gly 
                405                 410                 415     


Gln Tyr Leu His Asp Asn Arg Pro Lys Thr Leu Ala Ser Asn Gly Met 
            420                 425                 430         


Thr Ala Gln Arg Met Ile Lys Glu Lys Ile Asn Leu Phe Gly Asn Leu 
        435                 440                 445             


Ser Glu Val Thr Lys His Lys Ser Asp Phe Phe Glu Lys Glu Ser Ala 
    450                 455                 460                 


Ala Gln Gly Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Trp Ala Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Val Tyr Ile Asp Met Ile Gly Lys Glu Gly Lys Ala 
                485                 490                 495     


Lys Glu Ile Gln Val Gln Ile Asn Lys Tyr Arg Lys Gln Leu Asn Pro 
            500                 505                 510         


Ala Pro Gln Arg Asp Lys Arg Ile Ser Lys Lys Glu Ile Ile Glu Gln 
        515                 520                 525             


Leu Tyr Lys Glu Lys Val Val Tyr Gly Asp Pro Thr Leu Met Leu Ser 
    530                 535                 540                 


Ala Asn Glu Leu Met Ala Leu Leu Tyr Glu Leu Ile Val Asn Gly Lys 
545                 550                 555                 560 


Ser Gly Ala Glu Leu Glu Asn Lys Ile Val Glu Gln Ile Ile Ala Arg 
                565                 570                 575     


Tyr Glu Gln Ile Glu Ala Tyr Asp Pro Thr Thr Gln Gln Leu Pro Thr 
            580                 585                 590         


Asn Gln Met Pro His Lys Leu Gln Lys Ser Arg Lys Asp Ser Lys Val 
        595                 600                 605             


Thr Asp Thr Asp Lys Leu Leu Lys Thr Ile Asp Lys Glu Ile Asp Glu 
    610                 615                 620                 


Gly Asn Lys Lys Leu Glu Leu Ile Ala Cys His Arg Lys Glu Trp Glu 
625                 630                 635                 640 


Glu Ala Glu Gln Arg Lys Lys Ser Gly Lys Arg Asn Asn Pro Gly Thr 
                645                 650                 655     


Lys Ser Arg Lys His Leu Phe Tyr Ala Ser Glu Met Gly Glu Glu Ala 
            660                 665                 670         


Thr Trp Ile Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Pro Ala Arg 
        675                 680                 685             


Ala Glu Trp Lys Gly Thr His His Ser Glu Leu Gln Arg Leu Leu Ala 
    690                 695                 700                 


Phe Tyr Ser Thr Gln Arg Leu Glu Ala Trp Gln Leu Val Glu Ser Val 
705                 710                 715                 720 


Trp Thr Ala Asn Thr His Ser Phe Trp Glu Glu Asn Phe Lys Glu Ala 
                725                 730                 735     


Phe Tyr Lys Pro Glu Phe Glu Asn Phe Tyr Gly Ala Tyr Ile Glu Ile 
            740                 745                 750         


Arg Thr Lys Ile Leu Thr Thr Cys Arg Ser Ile Leu Glu Asn Asn Pro 
        755                 760                 765             


Glu Ala Thr Met Asn Asn Asp Thr Glu Lys Glu Trp Asp Lys Val Phe 
    770                 775                 780                 


Thr Leu Phe Asp Lys Arg Leu Tyr Arg Thr Ser Thr Thr Asp Glu Gln 
785                 790                 795                 800 


Lys Lys Gln Leu Leu Thr Lys Pro Phe Ala Phe Pro Arg Gly Leu Phe 
                805                 810                 815     


Asp Asp Lys Pro Thr Phe Leu Pro Gly Ser Lys Pro Asn Glu Asn Pro 
            820                 825                 830         


Glu Arg Phe Ala Ala Trp Tyr Ser Tyr Gly Tyr Thr Tyr Ser Gly Lys 
        835                 840                 845             


Phe Gln Ser Phe Tyr Asp Met Pro Arg Asn Tyr Ser Asp Trp Tyr Lys 
    850                 855                 860                 


Lys Leu Lys Glu Asp Gly Lys Leu Pro Arg Leu Asp Lys Lys Thr Glu 
865                 870                 875                 880 


Gln Glu Lys Ile Leu Arg Phe Arg Met Asp Cys Asp Leu Asn Ile Lys 
                885                 890                 895     


His Ile Arg Phe Gln Asp Ile Tyr Val Lys Leu Met Val Asp Ser Leu 
            900                 905                 910         


Tyr Lys Ala Val Phe Gly Gln Gln Pro Glu Phe Asp Leu Ser His Leu 
        915                 920                 925             


Tyr Asp Thr Arg Ser Glu Arg Tyr Glu Asn Asn Thr Ile Ala Gln Arg 
    930                 935                 940                 


Gln Lys Ser Arg Gln Glu Gly Asp Asn Ser Asp Asn Ala Ile Asn Glu 
945                 950                 955                 960 


Asn Tyr Val Trp Asn Lys Thr Phe Ala Ile Ser Leu Tyr Asn Gly Arg 
                965                 970                 975     


Ile Thr Glu Ser Gln Val Lys Leu Lys Asp Val Gly Lys Phe Arg Arg 
            980                 985                 990         


Phe Ala Thr Asp Pro Arg Val Gln  Thr Leu Ile Ser Tyr  Asp Asp Thr 
        995                 1000                 1005             


Arg Thr  Trp Thr Lys Leu Glu  Ile Glu Asn Glu Leu  Asp Asn Lys 
    1010                 1015                 1020             


Ala Asp  Ala Tyr Glu Pro Ile  Arg Arg Thr Gln Ser  Leu Lys Ala 
    1025                 1030                 1035             


Ile Gln  Gln Leu Glu Lys Asn  Ile Leu Lys Lys Asn  Gly Phe Asn 
    1040                 1045                 1050             


Gly Lys  Gln His Pro Glu Glu  Leu Lys His Asn Gly  Asn Pro Asn 
    1055                 1060                 1065             


Phe Arg  Lys Tyr Ile Ala Asn  Gly Leu Leu Lys His  Arg Thr Asp 
    1070                 1075                 1080             


Ile Arg  Gln Glu Glu Leu Ala  Leu Ile Ser Asp Thr  Glu Phe Gln 
    1085                 1090                 1095             


Glu Ile  Gly Leu Glu Arg Ile  Arg Gln Thr Asn Pro  Leu Ile Gln 
    1100                 1105                 1110             


Lys Ala  Tyr Leu Leu Ile Leu  Leu Arg Asn Lys Phe  Gly His Asn 
    1115                 1120                 1125             


Gln Leu  Pro Asp Gln Glu His  Phe Arg Leu Met Arg  Ser Ile Tyr 
    1130                 1135                 1140             


Pro Tyr  Asn Gln Gln Glu Ser  Tyr Ser Ala Tyr Phe  Asn His Val 
    1145                 1150                 1155             


Ile Thr  Gln Ile Ile Glu Glu  Leu Asn Thr 
    1160                 1165             


<210>  2142
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2142

Leu Gln Lys Gln Asp Lys Leu Phe Val Asp Arg Lys Lys Asn Ala Ile 
1               5                   10                  15      


Phe Ala Phe Pro Lys Tyr Ile Thr Ile Met Glu Asn Lys Glu Lys Thr 
            20                  25                  30          


Glu Pro Ile Tyr Tyr Glu Leu Thr Asp Lys His Phe Trp Ala Ala Phe 
        35                  40                  45              


Leu Asn Leu Ala Arg His Asn Val Tyr Thr Thr Val Asn His Ile Asn 
    50                  55                  60                  


Lys Leu Leu Glu Ile Ala Glu Leu Lys Asn Asp Glu Asp Val Leu Asn 
65                  70                  75                  80  


Ile Lys Asp Ser Trp Asn Lys Gln Ala Glu Lys Leu Asp Lys Lys Val 
                85                  90                  95      


Arg Leu Arg Asn Leu Leu Met Arg His Phe Pro Phe Leu Glu Ala Ala 
            100                 105                 110         


Ala Tyr Glu Lys Thr Thr Ser Lys Asp Ser Asn Ser Lys Glu Gln Lys 
        115                 120                 125             


Glu Lys Glu Gln Ala Glu Ala Leu Ser Leu Asp Asn Leu Lys Asn Val 
    130                 135                 140                 


Leu Phe Ile Phe Leu Glu Lys Leu Gln Ser Leu Arg Asn Tyr Tyr Ser 
145                 150                 155                 160 


His Tyr Lys Tyr Ser Glu Glu Ala Gln Lys Pro Thr Phe Glu Asn Asp 
                165                 170                 175     


Leu Leu Lys Asn Met Tyr Lys Ile Phe Asp Thr Asn Val Arg Leu Val 
            180                 185                 190         


Lys Arg Asp Tyr Met His His Glu Asn Val Asp Met Gln Arg Asp Phe 
        195                 200                 205             


Ser His Leu Asn Arg Lys Lys Gln Glu Gly Gln Thr Arg Lys Ile Ile 
    210                 215                 220                 


Ala Asn Pro Asn Phe Arg Tyr His Phe Ala Asp Lys Glu Gly Asn Met 
225                 230                 235                 240 


Thr Ile Ala Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Asp Lys Lys 
                245                 250                 255     


Asp Ala Ile Trp Met Gln Lys Lys Leu Lys Gly Phe Lys Asp Gly Arg 
            260                 265                 270         


Asn Leu Arg Glu Gln Met Thr Asn Glu Val Phe Cys Arg Ser Arg Ile 
        275                 280                 285             


Ser Leu Pro Lys Leu Lys Leu Glu Asn Val Gln Thr Lys Asp Trp Met 
    290                 295                 300                 


Gln Leu Asp Met Leu Asn Glu Leu Val Arg Cys Pro Lys Ser Leu Tyr 
305                 310                 315                 320 


Glu Arg Leu Arg Glu Lys Asp Arg Glu Ser Phe Lys Val Pro Phe Asp 
                325                 330                 335     


Ile Phe Ser Asp Asp Tyr Asp Ala Glu Glu Glu Pro Phe Lys Asn Thr 
            340                 345                 350         


Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe 
        355                 360                 365             


Asp Leu Asn Glu Ile Phe Glu Gln Leu Arg Phe Gln Ile Asp Leu Gly 
    370                 375                 380                 


Thr Tyr His Phe Ser Ile Tyr Asn Lys Arg Ile Gly Asp Glu Asp Glu 
385                 390                 395                 400 


Val Arg His Leu Thr His His Leu Tyr Gly Phe Ala Arg Ile Gln Asp 
                405                 410                 415     


Phe Ala Pro Gln Asn Gln Pro Glu Glu Trp Arg Lys Leu Val Lys Asp 
            420                 425                 430         


Leu Asp His Phe Glu Thr Ser Gln Glu Pro Tyr Ile Ser Lys Thr Ala 
        435                 440                 445             


Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Lys Phe Cys Ser 
    450                 455                 460                 


Ala His Asn Asn Leu Phe Pro Ser Leu Gln Thr Asp Lys Thr Cys Asn 
465                 470                 475                 480 


Gly Arg Ser Lys Phe Asn Leu Gly Thr Gln Phe Thr Ala Glu Ala Phe 
                485                 490                 495     


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu 
            500                 505                 510         


Thr Lys Asp Tyr Ser Arg Lys Glu Ser Ala Asp Lys Val Glu Gly Ile 
        515                 520                 525             


Ile Arg Lys Glu Ile Ser Asn Ile Tyr Ala Ile Tyr Asp Ala Phe Ala 
    530                 535                 540                 


Asn Gly Glu Ile Asn Ser Ile Ala Asp Leu Thr Cys Arg Leu Gln Lys 
545                 550                 555                 560 


Thr Asn Ile Leu Gln Gly His Leu Pro Lys Gln Met Ile Ser Ile Leu 
                565                 570                 575     


Glu Gly Arg Gln Lys Asp Met Glu Lys Glu Ala Glu Arg Lys Ile Gly 
            580                 585                 590         


Glu Met Ile Asp Asp Thr Gln Arg Arg Leu Asp Leu Leu Cys Lys Gln 
        595                 600                 605             


Thr Asn Gln Lys Ile Arg Ile Gly Lys Arg Asn Ala Gly Leu Leu Lys 
    610                 615                 620                 


Ser Gly Lys Ile Ala Asp Trp Leu Val Ser Asp Met Met Arg Phe Gln 
625                 630                 635                 640 


Pro Val Gln Lys Asp Thr Asn Asn Ala Pro Ile Asn Asn Ser Lys Ala 
                645                 650                 655     


Asn Ser Thr Glu Tyr Arg Met Leu Gln His Ala Leu Ala Leu Phe Asp 
            660                 665                 670         


Ser Glu Ser Ser Arg Leu Lys Ala Tyr Phe Arg Gln Met Asn Leu Val 
        675                 680                 685             


Gly Asn Ala Asn Pro His Pro Phe Leu Ala Glu Thr Gln Trp Glu His 
    690                 695                 700                 


Gln Thr Asn Ile Leu Ser Phe Tyr Arg Asn Tyr Leu Glu Ala Arg Lys 
705                 710                 715                 720 


Lys Tyr Leu Lys Gly Leu Lys Pro Gln Asn Trp Lys Gln Tyr Gln His 
                725                 730                 735     


Phe Leu Ile Leu Lys Val Gln Lys Thr Asn Arg Asn Thr Leu Val Thr 
            740                 745                 750         


Gly Trp Lys Asn Ser Phe Asn Leu Pro Arg Gly Ile Phe Thr Gln Pro 
        755                 760                 765             


Ile Arg Glu Trp Phe Glu Lys His Asn Asn Ser Lys Arg Ile Tyr Asp 
    770                 775                 780                 


Gln Ile Leu Ser Phe Asp Arg Val Gly Phe Val Ala Lys Ala Ile Pro 
785                 790                 795                 800 


Leu Tyr Phe Ala Glu Glu Tyr Lys Asp Asn Val Gln Pro Phe Tyr Asp 
                805                 810                 815     


Tyr Pro Phe Asn Ile Gly Asn Lys Leu Lys Pro Gln Lys Gly Gln Phe 
            820                 825                 830         


Leu Asp Lys Lys Glu Arg Val Glu Leu Trp Gln Lys Asn Lys Glu Leu 
        835                 840                 845             


Phe Lys Asn Tyr Pro Ser Glu Lys Lys Lys Thr Asp Leu Ala His Leu 
    850                 855                 860                 


Asp Phe Leu Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys 
865                 870                 875                 880 


Asn Gln Asp Ile Val Thr Trp Leu Met Phe Lys Glu Leu Phe Lys Thr 
                885                 890                 895     


Thr Thr Val Glu Gly Leu Lys Ile Gly Glu Ile His Leu Arg Asp Ile 
            900                 905                 910         


Asp Thr Asn Thr Ala Asn Glu Glu Ser Asn Asn Ile Leu Asn Arg Ile 
        915                 920                 925             


Met Pro Met Lys Leu Pro Val Lys Thr Tyr Glu Thr Asp Asn Lys Gly 
    930                 935                 940                 


Asn Ile Leu Lys Glu Arg Pro Leu Ala Thr Phe Tyr Ile Glu Glu Thr 
945                 950                 955                 960 


Glu Thr Lys Val Leu Lys Gln Gly Asn Phe Lys Val Leu Ala Lys Asp 
                965                 970                 975     


Arg Arg Leu Asn Gly Leu Leu Ser Phe Ala Glu Thr Thr Asp Ile Asp 
            980                 985                 990         


Leu Glu Lys Asn Pro Ile Thr Lys  Leu Ser Val Asp His  Glu Leu Ile 
        995                 1000                 1005             


Lys Tyr  Gln Thr Thr Arg Ile  Ser Ile Phe Glu Met  Thr Leu Gly 
    1010                 1015                 1020             


Leu Glu  Lys Lys Leu Ile Asp  Lys Tyr Ser Thr Leu  Pro Thr Asp 
    1025                 1030                 1035             


Ser Phe  Arg Asn Met Leu Glu  Arg Trp Leu Gln Cys  Lys Ala Asn 
    1040                 1045                 1050             


Arg Pro  Glu Leu Lys Asn Tyr  Val Asn Ser Leu Ile  Ala Val Arg 
    1055                 1060                 1065             


Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met Tyr Asp  Ala Thr Leu 
    1070                 1075                 1080             


Phe Ala  Glu Val Lys Lys Phe  Thr Leu Phe Pro Ser  Val Asp Thr 
    1085                 1090                 1095             


Lys Lys  Ile Glu Leu Asn Ile  Ala Pro Gln Leu Leu  Glu Ile Val 
    1100                 1105                 1110             


Gly Lys  Ala Ile Lys Glu Ile  Glu Lys Ser Glu Asn  Lys Asn 
    1115                 1120                 1125         


<210>  2143
<211>  1114
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2143

Met Lys Pro Phe Ser Glu Asn Asn Ser Val Ser Asn Ser Gly Glu Thr 
1               5                   10                  15      


Glu Lys Arg Glu Ala Tyr Ser Val Thr Asn Pro Asp His Lys Phe Phe 
            20                  25                  30          


Phe Cys His Phe Ala Asn Lys Ala Arg His Asn Ala Tyr Ile Ile Ile 
        35                  40                  45              


Asn Glu Val Ala Glu Ala Leu Gly Leu Glu Lys Arg Asp Glu Asn Asn 
    50                  55                  60                  


Leu Tyr Asn Ser Glu Ile Leu Arg Ile Asp Ser Ile Lys Asn Pro Glu 
65                  70                  75                  80  


Lys Phe Gly His Val Ile Gly Leu Leu Lys Lys His Phe Arg Phe Met 
                85                  90                  95      


Pro Tyr Leu Val Asp Lys Glu His Pro Gly Met Ala Leu Thr Tyr Leu 
            100                 105                 110         


Lys Asn Met Leu Ile Asp Leu Asn Cys Tyr Arg Asn Phe Phe Ser His 
        115                 120                 125             


Tyr His Tyr Glu Ser Lys Thr Pro Asp Phe Lys Met Phe Arg Ile Gly 
    130                 135                 140                 


Arg Pro Asn Val Thr Asp Ile Ser Leu Ala Tyr Leu Leu Arg Met Ala 
145                 150                 155                 160 


Val Lys Asp Ala Lys Lys Arg Leu Val Ala Phe Thr Asp Asp Asp Phe 
                165                 170                 175     


Lys Asp Ile Tyr Thr Ala Thr Tyr Lys Lys Asp Gly Ser Ile Asp Lys 
            180                 185                 190         


Arg Asn Phe Tyr Asn Leu Glu Glu Asn Leu Asn Lys Arg Val Ala Phe 
        195                 200                 205             


Phe Leu Ser Leu Phe Leu Glu Lys Asn Asp Gly Asn Glu Leu Ile Ser 
    210                 215                 220                 


Lys Ile Glu Gly Met Arg Gly Thr Gly Lys Lys Ser Tyr Ile Ala Asn 
225                 230                 235                 240 


Arg Glu Ser Phe Leu Gln Phe Trp Cys Thr Pro Pro Lys Pro Gln Ile 
                245                 250                 255     


Glu Ser Gly Asp Leu Gly Leu Glu Ile Leu Asn Glu Leu Asn Arg Ile 
            260                 265                 270         


Pro Ala Gln Leu Tyr Gln Ala Ile Asn Ser Asp Gly Lys Lys Lys Phe 
        275                 280                 285             


Glu Pro Asp Gln Asn Ile Gln Thr Glu Gly Ile Thr Thr Val Met Arg 
    290                 295                 300                 


Arg Tyr Gln Asn Arg Phe Pro Tyr Phe Ala Ile Arg Phe Phe Glu Glu 
305                 310                 315                 320 


Thr Asn Tyr Leu Pro Gln Leu Arg Phe His Asp Phe Leu Gly Gln Leu 
                325                 330                 335     


Cys Leu Gln Gln Tyr Pro Lys Phe Leu Asn Gly Lys Glu Asp Gln Arg 
            340                 345                 350         


Arg Ile Thr Lys Asp Ile Asn Ala Leu Gly Lys Leu Ala Ala Tyr Gln 
        355                 360                 365             


Thr Gly Asp Asn Ile Asn Pro Leu Trp Arg Thr Gln Glu Ala Val Ser 
    370                 375                 380                 


Glu Arg Leu Tyr Ser Asn Asp Glu Glu Ile Lys Lys Asn Ala Leu Asn 
385                 390                 395                 400 


Asn Asp Leu Leu Thr Phe Ala Pro Gln Tyr Arg Met Thr His Tyr Thr 
                405                 410                 415     


Ile Gly Ile Ile Leu Gln Asn Ile Asp Lys Thr Glu Trp Pro Thr Trp 
            420                 425                 430         


Gln Lys Lys Thr Asp Glu Lys Gly Arg Pro Lys Leu Ile Leu Lys Ser 
        435                 440                 445             


Ser Asp Tyr Ala Lys Pro Pro Gln Gly Lys Leu Ala His Pro Val Ala 
    450                 455                 460                 


Val Ile Ser Ala Met Glu Leu Gln Asn Leu Phe Leu Tyr Ala Trp Leu 
465                 470                 475                 480 


Tyr Lys Gln Lys Lys Ile Gln Lys Ser Pro Glu Asp Phe Ile Arg Asp 
                485                 490                 495     


Tyr Leu Glu Val Ile Lys Gln Cys Ile Asp Glu Thr Lys Asn Asp Thr 
            500                 505                 510         


Cys Glu Pro Val Thr Thr Glu Ser Tyr Leu Lys Arg Ser His Glu Lys 
        515                 520                 525             


Cys Ser Val Glu Leu Gln Lys Asn Lys Leu Gly Lys Val Arg Leu Leu 
    530                 535                 540                 


Arg Glu Lys Leu Leu Arg Asp Tyr Asn Ile Lys Pro Ser Asp Leu Pro 
545                 550                 555                 560 


Asp Leu Val Arg Glu Cys Leu Leu Asn Tyr Ser Tyr Pro His Leu Glu 
                565                 570                 575     


Glu Lys Leu Met Gln Lys Ile Glu Asn His Ile Gly Met Ala Gln Lys 
            580                 585                 590         


Trp Leu Asp Glu Ser Lys Lys Leu Lys Lys Leu Glu Lys Gly Arg Lys 
        595                 600                 605             


Lys Gly Leu Thr Ala Gly Lys Ile Gly Thr Arg Leu Ala His Glu Phe 
    610                 615                 620                 


Ile Ser Tyr Lys Thr Ser Thr Asp Lys Pro Asn Asp Gln Gln Tyr Asn 
625                 630                 635                 640 


Ile Leu Gln Glu Tyr Ile Ala Tyr Phe Gly Arg Asn Ile Lys Pro Leu 
                645                 650                 655     


Asp Asn Phe Leu Ser Glu Leu Lys Ile Ser Gly Thr Gly Asn His Leu 
            660                 665                 670         


Phe Ile Arg Asn Ser Leu Gln Glu Tyr Glu Thr Ser Phe Lys Glu Lys 
        675                 680                 685             


Ile Asn Ala Lys Lys Arg Ile Lys Lys Asp Asp Ile Thr Tyr Gly Val 
    690                 695                 700                 


Lys Ser Phe Tyr Glu Asp Tyr Leu Gly Asp Lys Ile Lys Tyr Leu Ala 
705                 710                 715                 720 


Ala Thr Leu Gln Gln Leu Lys Glu Asn Lys Leu Pro Ser His Glu Lys 
                725                 730                 735     


Val Leu Leu Leu Asn Ile Tyr His Ile Lys Glu Lys Ile Lys Glu Glu 
            740                 745                 750         


Trp Asp Tyr Asp Gly Leu His Val Arg Leu Pro Arg Gly Ile Phe Asn 
        755                 760                 765             


Thr Ala Ile Ala Glu Ala Val Lys Asp Glu Ile Gln Pro Gln Lys Gly 
    770                 775                 780                 


Arg Thr Ala Asn Pro Ser Tyr Val Ile Gly Asn Lys Phe Val Gln Ser 
785                 790                 795                 800 


Gln Lys Phe Tyr Glu Phe Glu Arg Glu Tyr Met Val Arg Glu Val Gln 
                805                 810                 815     


Asp Asn Lys Gln Lys Lys Ser Gly Lys Lys Pro Pro Gln Glu Glu Tyr 
            820                 825                 830         


Ile Gly Lys Val Glu Gly Ala Leu Asn Asn Ile Lys Asn Arg Thr Pro 
        835                 840                 845             


Lys Ser Glu Lys His Lys Ile Leu Ile Lys Arg Leu Phe Glu Lys Val 
    850                 855                 860                 


Glu Lys Asn Glu Lys Glu Val Arg Tyr Phe Gln Asn Thr Asp Arg Ile 
865                 870                 875                 880 


Leu Trp Glu Met Val Lys Glu Phe Tyr Lys Ser Ser Ile His Asn Arg 
                885                 890                 895     


Ile Thr Asn Lys Asn Glu Met Glu Ile Lys Met Glu Ser Ala Asn Leu 
            900                 905                 910         


Glu Lys Val Gly Phe Asn Val Asn Gln Thr Asn Asn Phe Leu Glu Glu 
        915                 920                 925             


Pro Val Glu Met Lys Gln Ser Ala Phe Gly Lys Thr Val Lys Thr Tyr 
    930                 935                 940                 


Ala Ser Ile Lys Asp Tyr Gly Ile Phe Arg Arg Leu Leu Arg Asp Lys 
945                 950                 955                 960 


Arg Leu Asp Ser Leu Leu Asn Trp Phe Glu Asn Pro Glu Asp Pro Asn 
                965                 970                 975     


Ser Ala Ser Ala Ile Ile Asp Lys Ser Asp Leu Asp Tyr Glu Leu Thr 
            980                 985                 990         


Lys Tyr Asp Ser Leu Arg Asp Asp  Val Ile Lys Thr Ile  Phe Glu Phe 
        995                 1000                 1005             


Glu Lys  Ala Cys Gly Glu His  Ser Arg Phe Ser Asn  Ile Ile Asn 
    1010                 1015                 1020             


Gln Lys  Ile Lys Thr Pro Gln  Gln Ile His Phe Ala  Leu Leu Glu 
    1025                 1030                 1035             


Glu Tyr  Ser Lys Ile Lys Asn  Ser Asp Asn Phe Pro  Ile His Thr 
    1040                 1045                 1050             


Leu Phe  Tyr Phe Arg Ser Lys  Phe Ile His Asn Glu  Phe Pro Asp 
    1055                 1060                 1065             


Ser Leu  Glu Asp Glu Met Lys  Asn Tyr Glu Pro Ile  Met Leu Ile 
    1070                 1075                 1080             


Lys Gln  Lys Gly Lys Pro Phe  Ile Thr Glu Ile Ala  Ala His Val 
    1085                 1090                 1095             


Ile Ser  Leu Tyr Gln Asn Leu  Thr Gln Glu Ile Asn  Ala Asn Leu 
    1100                 1105                 1110             


Ile 
    


<210>  2144
<211>  1145
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2144

Met Thr Leu Pro Thr Asp Asn Thr Phe Ile Glu Lys Ala Asp Gln Glu 
1               5                   10                  15      


Ile Leu Gly Lys Asn Lys Leu Phe Phe Gly Ala Tyr Leu Asn Met Ala 
            20                  25                  30          


Asn His Asn Ala Tyr Leu Ile Ile Lys Asp Ile Ser Glu Arg Leu Lys 
        35                  40                  45              


Gln Glu Asp Ala Leu Asp Ile Asp Ala Pro Ser Asp Glu Asp Asn Leu 
    50                  55                  60                  


Ala Tyr Ala Asp Ile Phe Ser Lys Ile Leu Lys Lys Ala Ser Asp Lys 
65                  70                  75                  80  


Asn Pro Lys Asn Arg Pro Gln Ala Thr Ile Ile Asp Lys Val Thr Asn 
                85                  90                  95      


Leu Leu Ile His His Phe Pro Ala Phe Glu Val Phe Ala Tyr Glu His 
            100                 105                 110         


Pro Phe Glu Gln Gln Asn Ser Tyr Pro Glu Leu Leu Tyr Gln Lys Leu 
        115                 120                 125             


Thr Thr Ala Leu Lys Leu Leu Asn Asp Leu Arg Asn Glu His Ser His 
    130                 135                 140                 


Phe Tyr Tyr Lys Gly Ser Phe Asp Ile Asp Thr Val Phe Ser Ala Ala 
145                 150                 155                 160 


Gln Glu Glu Ile Thr Arg Phe Pro Tyr Leu Thr Pro Glu Asp Ile Glu 
                165                 170                 175     


Glu Leu Glu Tyr Tyr Lys Asn Asp Leu Leu Glu Pro Leu Thr Tyr Phe 
            180                 185                 190         


Lys Lys Tyr Gly Phe Val Phe Phe Ile Cys Thr Phe Leu Glu Lys Arg 
        195                 200                 205             


Tyr Ala Arg Tyr Met Leu Lys Glu Lys Gln Leu Asp Leu Ile Ala Ser 
    210                 215                 220                 


Asp Lys Glu Arg Asp Ala Thr Leu Glu Asn Phe Thr Asn Tyr Ser Cys 
225                 230                 235                 240 


Arg Leu Pro Arg Pro Lys Leu Glu Ser Ser Val Ile Glu Leu Asp Met 
                245                 250                 255     


Leu Asn Glu Leu Ser Arg Cys Pro Lys Gly Ile His Asp Val Leu Ser 
            260                 265                 270         


Ser Pro Met Glu Lys Val Leu Leu Lys Thr Asp Ala Lys Asp Asp Pro 
        275                 280                 285             


Asn Gln Val Pro Met Ile Arg His Asn Asp Arg Phe Pro Tyr Phe Ala 
    290                 295                 300                 


Leu Ser Tyr Phe Asp Lys Met Glu Arg Phe Pro Ala Met Arg Phe His 
305                 310                 315                 320 


Ile Trp Ala Gly Lys Thr Arg Leu Ala Phe Tyr Gly Lys Lys Leu Gly 
                325                 330                 335     


Lys Lys Asn Val Leu Arg Asp Ile Gln Glu Asn Val Thr Ile Tyr Ala 
            340                 345                 350         


Arg Leu Asn Asp Ile Lys Ala Asp Lys Ile Pro Asp Asn Trp Lys Asp 
        355                 360                 365             


Lys Ile Asp Val Glu Asp Ser Glu Glu Asn Lys Glu Lys Ala Lys Ile 
    370                 375                 380                 


Gln Ser Tyr Ser Pro His Tyr Asn Ile His Asn Asn Arg Ile Ala Ile 
385                 390                 395                 400 


Lys Phe Ile Asp Thr Gln Lys Asp Glu Leu Asp Thr Glu Asn Phe Ser 
                405                 410                 415     


Glu Ile Lys Ser Lys Pro Gln Asp Pro Thr Lys Asp Lys Gln Leu Lys 
            420                 425                 430         


Tyr Thr Val Thr His Ala Leu Pro Asn Ala Ile Leu Ser Thr Tyr Glu 
        435                 440                 445             


Leu Gln Asn Leu Phe Leu Tyr Asp Tyr Leu Tyr Arg Thr Tyr Lys Asp 
    450                 455                 460                 


Gln Lys Val Leu Ala Arg Pro Ala Asp Ser Phe Ile Arg Asn Tyr Ile 
465                 470                 475                 480 


Ser Ser Phe His Arg Phe Cys Lys Asp Val Lys Ser Gly Lys Ile Gln 
                485                 490                 495     


Pro Val Ser Pro His Asp Phe Glu Arg Leu Thr Glu His Thr Arg Ser 
            500                 505                 510         


Thr Thr Arg Asp Leu Gly Asn Arg Glu Glu Glu Leu Glu Ile Arg Lys 
        515                 520                 525             


Glu Ala Leu Gln Lys Lys Lys Leu Asp Asn Tyr Gly Leu Lys Val Lys 
    530                 535                 540                 


Asn Leu Pro Asp Ala Leu Arg Glu Tyr Leu Leu Gly Tyr Lys Gln Glu 
545                 550                 555                 560 


Thr Tyr Thr Glu Ile Ala Leu Asn Lys Leu Arg Gly Lys Ile Lys Gln 
                565                 570                 575     


Thr Lys Val His Tyr Lys Leu Ala Thr Lys Asp Asp Leu Phe Leu Asp 
            580                 585                 590         


Gly Lys Thr Asp Leu Lys Ser Gly Lys Ile Gly Asp Phe Leu Ala Ala 
        595                 600                 605             


Asp Ile Val Phe Leu Lys Pro Leu Asp Ala Asn Arg Thr Gly Lys Pro 
    610                 615                 620                 


Asn Asn Gln Gln Phe Asn Glu Leu Gln Lys Ala Ile Ala Arg Phe His 
625                 630                 635                 640 


Ser Gln Lys Lys Asp Val Glu Asp Phe Ile Asn Glu Glu Leu Gln Ile 
                645                 650                 655     


Lys Glu Gln Ser Leu Pro His Ala His Pro Phe Leu Tyr Lys Ile Gln 
            660                 665                 670         


Phe Glu Glu His Thr Asp Val Gln Ser Phe Tyr Ile Lys Tyr Leu Glu 
        675                 680                 685             


Leu Lys Ile Glu Trp Leu Glu Cys Thr Lys Arg Glu Ile Gln Gly Lys 
    690                 695                 700                 


Ser Asp Tyr Leu Lys Pro Trp Gln Trp Arg Glu Glu Ala Asp Lys Cys 
705                 710                 715                 720 


Lys Gln Tyr Gly Ile Asp Ile Lys Pro Glu Gly Leu Ser Asp Ala Ala 
                725                 730                 735     


Thr Glu Asn Lys Tyr Gly Tyr Phe Leu Gln Ile Asn Thr Lys Lys Gly 
            740                 745                 750         


Asn Glu Arg Asn Tyr Thr Asn Ala Thr Thr Pro Ser Lys Ala Asn Ser 
        755                 760                 765             


Lys Glu Phe Glu Ser Leu Glu Ser Lys Ser Pro Val Ile Leu Pro Arg 
    770                 775                 780                 


Gly Leu Phe Asn Asp Ala Ile Ile Asp Ala Met Met Lys Ile Asp Glu 
785                 790                 795                 800 


Phe Lys Gly Lys Ile Lys Glu Gly Asp Asn Ile Val Arg Cys Leu Asp 
                805                 810                 815     


Val Leu Ala Glu Gly Asp Arg Gln Thr Phe Tyr Asp Phe Glu Arg Ser 
            820                 825                 830         


Tyr Thr Val Gly Lys Ala Ala Pro Thr Ser Val Thr Ile His Gln Gly 
        835                 840                 845             


Ala Asn Asp Glu Tyr Ile Lys Asn Lys Leu Arg Ser Ile Lys Pro Ile 
    850                 855                 860                 


Ile Lys Lys Leu Arg Thr Gln Gln Asn Ala Lys Asp Ala Lys Tyr Lys 
865                 870                 875                 880 


Asp Lys Lys Ile Leu Gln Asn His Ile Lys Ala Leu Gln Ala Ile Ser 
                885                 890                 895     


Asp Asn Glu Arg Ser Ile Arg Phe Ile Arg Ala Asn Asp Arg Ala Leu 
            900                 905                 910         


Phe Leu Met Ile Lys His Ile Phe Ser Glu His Lys Ser Tyr Val Val 
        915                 920                 925             


Glu Gly Ser Lys Leu Thr Lys Ser Ile Asn Thr Leu Pro Trp Lys Leu 
    930                 935                 940                 


Asn Lys Val Gly Tyr Glu Ile Lys Glu Asn Asn Ile Leu Asn Glu Ile 
945                 950                 955                 960 


Leu Pro Met Asn Ile Gln Phe Asn Gln Lys Asn Ile Tyr Thr Glu Gly 
                965                 970                 975     


Glu Tyr Gly Thr Asp Pro Leu Asn Lys Leu Ser Ile Lys His Tyr Gly 
            980                 985                 990         


Lys Phe Arg Lys Leu Leu Lys Asp  Lys Arg Leu Ser Asn  Lys Lys Lys 
        995                 1000                 1005             


Pro Gly  Leu Leu Asn Tyr Tyr  Thr Asp Gln Asn Val  Arg Trp Ser 
    1010                 1015                 1020             


Ala Ile  Asn Lys Glu Leu Glu  Tyr Tyr Asp Glu Asn  Arg Asp Arg 
    1025                 1030                 1035             


Leu Leu  Asp Val Ile Tyr Lys  Phe Glu Lys Ala Val  Trp Glu Asn 
    1040                 1045                 1050             


Glu Glu  Cys Arg Glu Glu Leu  Lys Glu Asn Ile Arg  Leu Gly Tyr 
    1055                 1060                 1065             


Ile Asn  His Ala Ala Gln Leu  Lys Ala Val Gly Lys  Ile Val Arg 
    1070                 1075                 1080             


Asp Phe  Thr Ala Ser Lys Gln  Asp Gln Leu Ala Leu  Leu Arg Asn 
    1085                 1090                 1095             


Lys Phe  Leu His Asn Gln Ile  Pro Tyr Thr Glu Asn  Leu Lys Thr 
    1100                 1105                 1110             


Gly Trp  Val Asp Asn Asn Pro  Glu Tyr Pro Leu Ile  Thr Gln Ala 
    1115                 1120                 1125             


Leu Leu  Glu Leu Ala Ile Ile  Glu Tyr Gln Asn Ile  Thr Lys Asn 
    1130                 1135                 1140             


Ile Ile  
    1145 


<210>  2145
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2145

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2146
<211>  1133
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2146

Met Ser Val Arg Gln Glu Glu Ile Gln Thr Trp Ile Ala Arg Lys Cys 
1               5                   10                  15      


Val Lys Glu Thr Glu Met Lys Lys Tyr Trp Ala Ala Tyr Met Asn Met 
            20                  25                  30          


Ala Arg Asn Asn Leu Phe Val Thr Leu Met Ser Ile Ser Arg Ser Val 
        35                  40                  45              


Gly Asp Pro Glu Pro Ile Lys Gly Asp Asn Ile Glu Ser Asn Ile Gln 
    50                  55                  60                  


Asn Leu Gly Val Leu Arg Arg Glu Leu Thr Pro Glu Met Glu Glu Lys 
65                  70                  75                  80  


Thr Lys Ser Leu Phe Phe Lys His Phe Pro Phe Leu Arg Ala Leu Ser 
                85                  90                  95      


Val Lys Glu Glu Gln Lys Glu Glu Ser Gly Gly Ala Gln Ile Pro Thr 
            100                 105                 110         


Leu Gln Asp Leu Arg Asn Cys Ile Thr Asp Phe Ala Cys Thr Leu Gly 
        115                 120                 125             


His Tyr Arg Asn Val Asn Ser His Ser Ile Phe Ile Asp Lys Arg Glu 
    130                 135                 140                 


Asp Gly Val Ile Glu Arg Ala Gln Gly Ser Glu Arg Arg Cys Gly Gly 
145                 150                 155                 160 


Tyr Leu Gln Ser Ile Leu Thr Val Ser Thr Arg Thr Ile Lys Glu Arg 
                165                 170                 175     


Tyr Arg Ala Gly Lys Asn Ser Val Gln Lys Gly Met Ile Asp Glu Glu 
            180                 185                 190         


Ser Phe Lys Phe Ile Thr Asp Ser Lys Val Arg Ile Ser Tyr Arg Gly 
        195                 200                 205             


Arg Asp Arg Ile Thr Thr Pro Asn Glu Arg Tyr Tyr Leu Asn Thr Phe 
    210                 215                 220                 


Asp Lys Asp Gly Val His Leu Ser Phe Phe Gly Lys Leu Met Met Thr 
225                 230                 235                 240 


Cys Leu Leu Leu Glu Lys Lys Tyr Ala Thr Glu Leu Leu Thr Gln Cys 
                245                 250                 255     


His Phe Leu Asp Ala Phe Ser Gly Asp Ala Glu Ser Pro Lys Leu Pro 
            260                 265                 270         


Glu Arg Arg Leu Ile Leu Glu Val Met Thr Ala Leu Arg Ile Arg Leu 
        275                 280                 285             


Pro Glu Arg Lys Leu Ser Ile Glu Lys Asp Glu Val Gln Ile Ala Leu 
    290                 295                 300                 


Asp Ile Leu Asn Glu Leu Lys Lys Cys Pro Tyr Glu Leu Tyr Asp Leu 
305                 310                 315                 320 


Leu Gly Asp Glu Asp Lys Ser Leu Phe Arg Ile Val Ser Asp Thr Gly 
                325                 330                 335     


Asp Ser Val Leu Leu Arg Arg Ser Asp Asp Arg Phe Pro Gln Leu Ala 
            340                 345                 350         


Leu Ser Leu Leu Asp Ser Gly Arg Ser Phe Asp Arg Leu Arg Phe Gln 
        355                 360                 365             


Val Asn Ala Gly Lys Leu Arg Tyr Leu Phe Arg Glu Glu Lys Arg Cys 
    370                 375                 380                 


Val Asp Gly Gln Thr Arg Met Arg Val Ile Glu Glu Pro Leu Asn Gly 
385                 390                 395                 400 


Phe Arg Arg Arg Gly Glu Leu Glu Glu Glu Arg Val Arg Lys Gln Ser 
                405                 410                 415     


Glu Gly Ser Gly Leu Trp Leu Gly Leu Lys Ile Leu Ser Gln Glu Asp 
            420                 425                 430         


Ala Pro Arg Asn Asp Ala Ser Leu Leu Pro Tyr Ile Thr Asp Ser Arg 
        435                 440                 445             


Thr Arg Tyr Ile Leu Asp Gly Asp Asn Ile Gly Met Ser Val Gly Asp 
    450                 455                 460                 


Phe Thr Pro Ser Ile Val Lys Met Asp Asp Val Arg Tyr Lys Val Glu 
465                 470                 475                 480 


Gly Lys Val Pro Asp Cys Tyr Leu Ser Lys Tyr Glu Leu Pro Gly Leu 
                485                 490                 495     


Leu Phe Tyr His His Leu Thr Arg Gly His Ser Asn Met Asn Trp Lys 
            500                 505                 510         


Ser Ala Glu Gln Ile Ile Ile Asp Thr Ile Gly His Tyr Arg Lys Leu 
        515                 520                 525             


Phe Ser Asp Val Lys Asn Gly Val Leu Val Pro Ser Ala Gly Glu Gly 
    530                 535                 540                 


Glu Lys Gln Leu Ser Ala Arg Leu Met Ser Ser Tyr Gly Val Ala Leu 
545                 550                 555                 560 


Pro Asp Val Pro Glu Lys Ile Ala Asp Tyr Leu Leu Glu Arg Glu Cys 
                565                 570                 575     


Gly Gly Val Glu Lys Phe Lys Leu Trp Lys Gln Arg Ile Leu Asp Ser 
            580                 585                 590         


Leu Ile Gln Asp Thr Glu Lys Arg Leu Glu Lys Leu Asp Asp Val Ser 
        595                 600                 605             


Lys Arg Val Arg Ser Ser Asp Asn Lys Pro Gly Lys Lys Asn Tyr Val 
    610                 615                 620                 


Tyr Tyr Lys Pro Gly Ala Tyr Ala Ser Phe Val Ala Glu Asp Ile Val 
625                 630                 635                 640 


Phe Phe Gln Glu Cys Gly Ala Ser Glu Lys Leu Thr Gly Leu Asn Phe 
                645                 650                 655     


Lys Val Leu Gln Ser Arg Met Ala Thr Phe Val Arg Gly Glu Ala Thr 
            660                 665                 670         


Ser Met Asp Ile Leu Arg Gln Thr Phe Arg Asn Ala Gly Leu Ile Ser 
        675                 680                 685             


Gly Thr Cys Gly Lys Gly Asn His Pro Phe Leu Tyr Arg Val Val Ser 
    690                 695                 700                 


Gln Ser Ser Gln Asp Ile Val Asp Phe Tyr Asn Leu Tyr Leu Lys Glu 
705                 710                 715                 720 


Lys Lys Thr Tyr Leu Ile Ser Gly Ile Pro Asp Asp Ala Thr Phe Leu 
                725                 730                 735     


His Arg Glu Arg Ala Lys Trp Glu Asp Arg Asp Ala Gln Tyr Tyr Met 
            740                 745                 750         


Asn Leu Ala Ala Arg Tyr Leu Glu Arg Pro Ile Gln Leu Pro Arg Gln 
        755                 760                 765             


Met Phe Glu Arg Ala Ile Arg Ala Ile Leu Leu Ser Ser Phe Ile Gln 
    770                 775                 780                 


Gly Glu Ser Gly Asp Met Lys Ser His Ile Lys Glu Ala Phe Ser Asn 
785                 790                 795                 800 


Gly Arg Cys Asn Thr Ala Phe Met Ile Met Glu Tyr Phe Asn Glu Tyr 
                805                 810                 815     


Leu Asn Asp Gly Ser Gln Ser Phe Tyr Gly Leu Phe Glu Gly Asp Leu 
            820                 825                 830         


Asn His Cys Gln Gly Tyr Gly Phe Tyr Ser Leu Ile Arg Asn Asn Leu 
        835                 840                 845             


Arg Thr Ala Lys Thr Leu Val Lys Ser Arg Arg Gly Ile Asp Gly Ala 
    850                 855                 860                 


Ser Ser Asn Tyr Ala Arg Phe Leu Glu Glu Ala Val Arg Ser Ile Lys 
865                 870                 875                 880 


Glu Val Ser Val Gly Ser Asn Asp Leu Gly His Lys Leu Pro Ile Glu 
                885                 890                 895     


Glu Leu Ser Gly Lys Leu Lys Ser Ala Tyr Lys Asp Met Met Asn Thr 
            900                 905                 910         


Glu Lys Arg Leu Arg Arg Tyr Ala Val Gln Asp Gln Val Leu Phe Leu 
        915                 920                 925             


Glu Ala Arg Arg Val Ile Trp Thr Tyr Trp Gly Ile Lys Asp Lys Glu 
    930                 935                 940                 


Asn Glu Cys Leu Leu Gly Asp Ile Met Pro Asn Gly Gly Ser Leu Leu 
945                 950                 955                 960 


Asp Leu Val Met Pro Tyr Ile Glu Thr Ser Tyr Arg Val Arg Ser Gly 
                965                 970                 975     


Asn Phe Gly Arg Met Lys Glu Phe Glu Ala Lys Val Arg Gln Glu Asn 
            980                 985                 990         


Val Ser Val Lys Asp Tyr Gly Lys  Val Phe Lys Leu Phe  Asn Asp Arg 
        995                 1000                 1005             


Arg Val  Asn Asp Leu Leu Ser  Leu His Gly Lys Glu  Ser Ala Lys 
    1010                 1015                 1020             


Met Asp  Asp Ile Cys Glu Glu  Leu Asp Arg Tyr Asp  Arg His Arg 
    1025                 1030                 1035             


Val Gly  Val Phe Gly Asp Ile  Leu Lys Tyr Glu Asp  Lys Ile Thr 
    1040                 1045                 1050             


Lys Gly  Ile Pro Glu Asn Asp  Leu Val Lys Asp Asn  Gly Val Val 
    1055                 1060                 1065             


Asp Phe  Lys Val Val Gln Gly  Tyr Asp Tyr Gln Asn  Ser Glu Glu 
    1070                 1075                 1080             


Asp Lys  Ile Asp Leu Arg Val  Ile Arg Asn Ala Phe  Ala His Asn 
    1085                 1090                 1095             


Gln Tyr  Pro Gln Lys Lys Gly  Ser Pro Val Lys Tyr  Gly Val Asp 
    1100                 1105                 1110             


Met Pro  Glu Ile Ala Asp Arg  Ile Ser Glu Ile Val  Lys Asp Ile 
    1115                 1120                 1125             


Glu Glu  Lys Thr Glu 
    1130             


<210>  2147
<211>  1123
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2147

Met Lys Ile Pro Gln Ile Ile Glu Asp Asn Lys His Leu Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Thr Met Ala Leu Ala Asn Ile Arg Asn Ile Leu Asp His Ile 
            20                  25                  30          


Ala Thr Leu Ala Cys Ile Glu Asn Asp Phe Asn Ala Asp Ser Asp Asp 
        35                  40                  45              


Phe Trp His His Pro Cys Ile Glu Ile Ile Asn Pro Gln Asn Leu Cys 
    50                  55                  60                  


Asn Asp Val Thr Lys Ala Asp Phe Val Thr Glu Lys Leu Lys Ser His 
65                  70                  75                  80  


Phe Pro Phe Val Val Ile Met Ala Glu Ala Lys Arg Gln Lys Asp Ile 
                85                  90                  95      


Ala Trp Ala Lys Asn Gln Ala Lys Lys Ala Phe Glu Asn Arg Asp Phe 
            100                 105                 110         


Gln Lys Gln Gln Glu Phe Asn Lys Lys Gln Lys Ser Leu Leu Ser Ile 
        115                 120                 125             


Thr Asn Ala Asp Ile Tyr Arg Met Leu Asn Asn Leu Phe Arg Val Leu 
    130                 135                 140                 


Thr Ser Tyr Arg His Tyr Thr Ser His Tyr Leu Ile Asn Tyr Ile Tyr 
145                 150                 155                 160 


Phe Asn Glu Gly Ser Asn Leu Leu Lys Tyr Asn Glu Gln Pro Leu Ser 
                165                 170                 175     


Tyr Asn Leu Asn Asp Tyr Phe Thr Ile Ala Leu Arg Asp Thr Ala Gln 
            180                 185                 190         


Lys Tyr Ser Tyr Ser Pro Glu Ala Leu Ser Phe Ile Gln Ser Ser Arg 
        195                 200                 205             


Tyr Lys Ile Glu Asn Arg Arg Lys Ile Leu Asp Thr Asp Phe Phe Leu 
    210                 215                 220                 


Ser Ile Gln His Arg Asn Gly Asp Ser Asn Pro Lys Asn Leu His Ile 
225                 230                 235                 240 


Ser Gly Val Gly Val Ala Leu Leu Ile Cys Leu Phe Leu Glu Lys Lys 
                245                 250                 255     


Tyr Val Asn Val Phe Leu Gln Lys Leu Pro Ile Tyr Gly Thr Tyr Lys 
            260                 265                 270         


Lys Gln Ser Met Glu Ala Asn Ile Ile Arg Gln Thr Phe Gly Ile His 
        275                 280                 285             


Thr Ala Lys Leu Pro Lys Glu Arg Ile Val Ser Glu Lys Ser Asp Phe 
    290                 295                 300                 


Ser Ile Gly Met Asp Met Leu Asn Glu Leu Lys Arg Cys Pro Lys Ala 
305                 310                 315                 320 


Leu Phe Ser Thr Leu Ser Tyr Ala Asp Gln Asn Ala Phe Arg Ile Val 
                325                 330                 335     


Ser Ser Asp Met Asn Asp Val Leu Gln Val Arg His Thr Asp Arg Phe 
            340                 345                 350         


Ala Gln Leu Ser Leu Glu Tyr Ile Asp Arg Arg Glu Leu Phe Ser Asp 
        355                 360                 365             


Ile Arg Phe His Leu Asn Met Gly Lys Leu Arg Tyr Leu Lys Thr Ala 
    370                 375                 380                 


Asp Lys His Cys Ile Asp Gly Ile Ser Arg Val Arg Val Leu Glu Asp 
385                 390                 395                 400 


Lys Ile Asn Ala Phe Gly Arg Ile His Glu Phe Glu Ala Arg Arg Lys 
                405                 410                 415     


Glu Leu Gly Phe Val Glu Cys Tyr Glu Gln Gly Gly Arg Ala Ile Ser 
            420                 425                 430         


Thr Asn Thr Asn Ile Glu Ile Arg Asp Phe Glu His Val Lys Arg Asp 
        435                 440                 445             


Asp Ser Asn Pro Asp Ser Tyr Pro Tyr Ile Ile Asp Thr Tyr Thr His 
    450                 455                 460                 


Tyr Ile Leu Glu Asn Asn Lys Ile Gly Met His Ile Gly Asp Tyr Trp 
465                 470                 475                 480 


Pro Asp Leu Ile Lys Leu Asp Glu His Lys Trp Thr Val Tyr Asn Glu 
                485                 490                 495     


Asn Pro Thr Cys Phe Met Ser Ser Leu Glu Leu Pro Ala Met Met Phe 
            500                 505                 510         


His Met Met Leu Cys Gly Ser Asp Ala Thr Glu Ser Leu Ile Lys Ala 
        515                 520                 525             


Glu Val Asp Lys Tyr Lys Lys Leu Phe Gly Ala Met Ala Asn Gly Thr 
    530                 535                 540                 


Leu Thr Lys Glu Asn Ile Ser Gly Phe Gly Ile Ala Glu Glu Asn Ile 
545                 550                 555                 560 


Pro Gln Lys Val Ile Asp Cys Val Asn Gly Lys Thr Ser Gly Lys Gly 
                565                 570                 575     


Leu Asp Lys Gln Ile Lys Lys Glu Ile Asp Glu Met Leu Ala Asp Thr 
            580                 585                 590         


Asn Leu Arg Ile Glu Arg Leu Lys Ser Asp Lys Arg Ser Val Ala Ser 
        595                 600                 605             


Thr Gln Asn Lys Met Gly Lys Arg Gly Phe Arg Ser Ile Gln Pro Gly 
    610                 615                 620                 


Lys Leu Ala Asp Trp Leu Ala Ala Asp Ile Val Lys His Gln Pro Ser 
625                 630                 635                 640 


Leu Leu Lys Gly Val Asp Tyr Gly Thr Asp Arg Ile Thr Gly Met Asn 
                645                 650                 655     


Tyr Arg Val Met Gln Ser Thr Ile Ala Thr Phe Asn Ala Thr Thr Pro 
            660                 665                 670         


Glu His Ser Leu Glu Glu Leu Lys Lys Val Phe Ser Ala Ala Gln Leu 
        675                 680                 685             


Ile Gln Cys Glu Lys Lys Glu His Pro Phe Leu Tyr Lys Ala Leu Asp 
    690                 695                 700                 


Arg Asn Pro Gln Asn Thr Ile Asp Leu Tyr Glu Phe Tyr Leu Ser Ala 
705                 710                 715                 720 


Lys Gln Ser Tyr Tyr Lys Ser Met Arg Arg Asn Ile Glu Asn Gly Glu 
                725                 730                 735     


Asn Val Lys Leu Pro Tyr Leu Asn Thr Asp Arg Asn Lys Trp Met Arg 
            740                 745                 750         


Arg Gly Ser Val Tyr Tyr Ser Thr Met Gly Glu Ile Tyr Leu Lys Asp 
        755                 760                 765             


Met Pro Ile Glu Leu Pro Arg Gln Met Phe Asp Lys Lys Ile Lys Glu 
    770                 775                 780                 


Ala Leu Ala Lys Leu Pro Ser Met Lys Asp Val Asp Met Gln His Cys 
785                 790                 795                 800 


Asn Val Thr Phe Leu Ile Ala Glu Tyr Leu Lys Lys Glu Leu Lys Asp 
                805                 810                 815     


Asp Ser Gln Pro Phe Tyr Gln Trp Asn Arg Asn Tyr Arg Phe Thr Asp 
            820                 825                 830         


Met Met Ile Cys Glu Glu Asn Arg Ser Thr Arg Ala Leu Ser Thr His 
        835                 840                 845             


Phe Ile Pro Val Ala Leu Arg Glu Glu Ile Trp Glu Lys Arg Ser Glu 
    850                 855                 860                 


Leu Arg Ala Ala Tyr Lys Glu Trp Ala Leu Pro Arg Leu Ser Lys Asn 
865                 870                 875                 880 


Arg Asp Thr Glu Arg Leu Ser Pro Ala Gln Lys Ser Glu Leu Leu Asp 
                885                 890                 895     


Ala Arg Ile Ala Lys Cys Arg Asn Glu Tyr Gln Lys Asn Glu Lys Ile 
            900                 905                 910         


Ile Arg Arg Tyr Lys Val Gln Asp Ala Leu Met Phe Met Met Val Lys 
        915                 920                 925             


Asp Met Phe Gly Lys Gly Val Phe Thr Ala Glu Ser Lys Glu Phe Ala 
    930                 935                 940                 


Leu Ser Ala Ile Thr Pro Asp Ala Lys Arg Gly Ile Leu Ser Glu Val 
945                 950                 955                 960 


Ile Pro Ile Asp Phe Lys Phe Ser Ile Asp Gly Lys Thr Tyr Thr Ile 
                965                 970                 975     


His Ser Asn Gly Met Lys Ile Lys Asn Tyr Gly Asp Phe Tyr Lys Leu 
            980                 985                 990         


Ile Asn Asp Lys Arg Met Lys Ser  Ile Leu Lys Ile Ile  Thr His Asn 
        995                 1000                 1005             


Val Ile  Asp Lys Asp Leu Leu  Glu Lys Glu Phe Ser  Ser Tyr Asp 
    1010                 1015                 1020             


Asp Lys  Arg Pro Glu Ala Ile  Glu Ile Val Phe Glu  Phe Glu Lys 
    1025                 1030                 1035             


Ala Ala  Tyr Ser Lys Tyr Pro  Glu Leu Glu Glu Leu  Val Leu Ser 
    1040                 1045                 1050             


Glu Asn  His Phe Asp Phe Gly  Thr Leu Leu Arg Glu  Leu Gln Ala 
    1055                 1060                 1065             


Lys Lys  Val Leu Ser Gln Asn  Asp Gly His Tyr Leu  Ser Gln Ile 
    1070                 1075                 1080             


Arg Asn  Ala Phe Ser His Asn  Ser Tyr Pro Arg Asn  Leu Arg Ile 
    1085                 1090                 1095             


Thr Ser  Asn Ile Pro Glu Ile  Ala Gln Glu Met Ile  Asn Ile Phe 
    1100                 1105                 1110             


Arg Ile  Thr Thr Pro Leu Lys  Thr Lys Lys 
    1115                 1120             


<210>  2148
<211>  1140
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2148

Met Glu Asn Asp Gln Gln Ile Leu Glu Asn Arg Arg Arg Thr Leu Ala 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Ser Asn His Leu Ala Ala Ser Phe Glu Gln Lys Val 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ala Ser Phe Leu Cys Asn Lys Ser 
    50                  55                  60                  


Ile Lys Lys Ile Asn Trp Asn His Val Tyr Ser Lys Ala Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ala Asp Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Arg Glu Thr Thr Asp Lys Glu Gly Lys Asp Phe Thr Ala Met Asn Glu 
            100                 105                 110         


Thr Leu Lys Leu Val Phe Asp Glu Leu Gln Ala Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Ala Asp Ser Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Val Glu Leu Ala Asp Phe Leu Thr Val Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Ala Asp Asp Asp Tyr 
                165                 170                 175     


Thr Met Val Glu Ser Lys Gln Ile Val Thr Pro Asp Asn Leu Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Val Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Leu Ala Tyr Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asp Leu Gly Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Glu 
            260                 265                 270         


Val Ile Thr Glu Glu Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Glu Glu Glu Arg 
    290                 295                 300                 


Glu Lys Ile Leu Asp Glu Ile Asp Tyr Glu Asp Tyr Ile Glu Ser Leu 
305                 310                 315                 320 


Thr Arg Arg Val Arg His Ser Asn Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Lys Tyr Asn Lys Gln Phe Asp Gly Glu 
        355                 360                 365             


Ala Thr Glu Cys Lys Val Val Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asn Gln Glu Thr Val Glu Leu Lys Ile Asp Ser Ala 
385                 390                 395                 400 


Gln Arg Thr Asn Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Glu Ala Arg Leu Leu 
            420                 425                 430         


Thr Lys Ala Lys Pro Glu Ser Lys Val Ser Tyr Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Lys Ala Glu Glu Met Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Lys Val Asn Asp Ser Gln Leu Met Ser Met Gln Phe Ile Asp Glu 
                485                 490                 495     


Ile Lys Glu Gln Leu Pro Ala Asp Trp Asn Glu Phe Gly Lys Arg Ser 
            500                 505                 510         


Asp Ser Lys Lys Lys Lys Ala Tyr Thr Asn Ala Ala Leu Gln Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Lys Val Leu Ala Asn Tyr Gln Leu 
    530                 535                 540                 


Asn Asp Lys Gln Val Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Ser Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Val Glu Lys His Lys Leu 
            580                 585                 590         


Asp Lys Ser Ala Arg Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Thr Asp Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Phe Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Tyr 
625                 630                 635                 640 


Ala Asp Thr Asp Lys Lys Ala Thr Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Lys Gly Gly His Pro Phe Leu Ala Asn Ile Asn 
            660                 665                 670         


Leu Arg Gln Ile Arg Lys Thr Ser Gln Leu Tyr Glu Leu Tyr Leu Val 
        675                 680                 685             


Glu Lys Ala Asn Lys Gln Val Lys Lys Met Asn Pro Lys Thr Gln Arg 
    690                 695                 700                 


Thr Ser Asn Val Asp Glu Ser Trp Met Met Lys Ser Phe Tyr Ala Lys 
705                 710                 715                 720 


Glu Trp Asn Glu Glu Met Gly Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Val Asn Lys Thr Asn Ile Pro Phe Thr Ile Arg Gln Trp Glu Glu Lys 
            740                 745                 750         


Glu Lys His Asn Leu Gln Ala Trp Leu His Asn Ile Thr Lys Gly Lys 
        755                 760                 765             


Thr Ser Lys Asp Gly Lys Lys Ala Ile Asp Leu Pro Thr Asn Leu Phe 
    770                 775                 780                 


Asp Asp Thr Leu Cys Glu Leu Leu Arg Glu Ala Leu Ile Asn Gln Gly 
785                 790                 795                 800 


Ile Asp Ala Thr Pro Thr Thr Lys Tyr Asn Glu Leu Leu Lys Gln Trp 
                805                 810                 815     


Trp Thr Ala Arg Glu Asp Ser Thr Gln Asp Phe Tyr Leu Ser Glu Arg 
            820                 825                 830         


Gln Tyr Asp Ile Tyr Asp Glu Lys Val Cys Phe Thr Ile Asn Ser Ser 
        835                 840                 845             


Ala His Phe Ala Asp Tyr Tyr Ala Pro Ala Leu Asn Lys Ala Tyr Ser 
    850                 855                 860                 


Arg Leu Arg Ala Glu Arg Asp Val Ala Arg Arg Thr Asp Lys Arg Leu 
865                 870                 875                 880 


Pro Pro Val Glu Arg Lys Asp Val Glu Arg Val Phe Lys Asn Thr Ile 
                885                 890                 895     


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
            900                 905                 910         


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asn Gln Gln Gln Leu Lys 
        915                 920                 925             


Leu Ser Lys Met Asp Ser Leu Leu Asn Glu Thr Lys Arg Ile Glu Gln 
    930                 935                 940                 


Thr Ile Asn Thr Gln Leu Ser Phe Asp His Lys Gly Lys Glu Ile Lys 
945                 950                 955                 960 


Asp Lys Thr Asn Ser Glu Ile Val Lys Thr Ile Val Ala Glu Arg Lys 
                965                 970                 975     


Gln Lys Asn Tyr Thr Glu Met Arg Lys Tyr Val His Asp Arg Arg Leu 
            980                 985                 990         


Pro Glu Leu Phe Glu Tyr Ile Asp  Gly Asn Glu Leu Pro  Leu Asp Val 
        995                 1000                 1005             


Leu Leu  Asn Glu Leu Arg Ala  Tyr Asn Thr Ala Lys  Gln Met Val 
    1010                 1015                 1020             


Phe Asp  Thr Val Phe Ala Leu  Glu Lys Lys Ile Ile  Glu Thr Asp 
    1025                 1030                 1035             


Pro Glu  Gly Leu Lys Gln Leu  Asn Val Gly Lys Asn  Gly Gln Ile 
    1040                 1045                 1050             


Gln Thr  Gly Asn Ile Gln His  Lys Pro Tyr Val Gln  Trp Leu Glu 
    1055                 1060                 1065             


Asn Lys  Gly Leu Ile Thr Asp  His Gln Lys Gln Phe  Ile Asn Met 
    1070                 1075                 1080             


Val Arg  Asn Ser Phe Ser His  Asn Gln Phe Pro Gln  Arg Ser Thr 
    1085                 1090                 1095             


Val Glu  Leu Leu Met Pro Glu  Trp Gln Asn Thr Asp  Ile Ala Leu 
    1100                 1105                 1110             


Gln Ile  Ala Arg Glu Tyr Gln  Gln Leu Ile Val Asp  Ile Ile Glu 
    1115                 1120                 1125             


Lys Ser  Leu His Pro His Lys  Gln His Gln Met Val  
    1130                 1135                 1140 


<210>  2149
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2149

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Leu Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Val Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2150
<211>  1146
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2150

Met Glu Ser Ile Ile Gly Leu Gly Leu Ser Phe Asn Pro Tyr Lys Thr 
1               5                   10                  15      


Ala Asp Lys His Tyr Phe Gly Ser Phe Leu Asn Leu Ala Asp Asn Asn 
            20                  25                  30          


Leu Lys Ala Val Phe Ala Glu Phe Lys Glu Arg Ile Ser Asp Lys Ser 
        35                  40                  45              


Lys Asp Glu Asp Ile Ser Asn Leu Ile Glu Lys His Phe Ile Asp Asn 
    50                  55                  60                  


Met Ser Ile Val Asp Tyr Glu Lys Asn Ile Ser Ile Leu Asn Gly Tyr 
65                  70                  75                  80  


Leu Pro Ile Ile Asp Phe Leu Asp Asp Glu Leu Glu Asn Asn Leu Asn 
                85                  90                  95      


Thr Arg Val Lys Asn Phe Lys Lys Ser Phe Ile Ile Leu Ala Glu Ala 
            100                 105                 110         


Leu Glu Thr Leu Arg Asn Tyr Tyr Thr His Phe Tyr His Asp Pro Ile 
        115                 120                 125             


Thr Phe Gly Asp Asn Lys Glu Pro Leu Leu Glu Leu Leu Asp Glu Val 
    130                 135                 140                 


Leu Leu Lys Thr Ile Leu Asp Val Lys Lys Lys Tyr Leu Lys Thr Asp 
145                 150                 155                 160 


Lys Thr Lys Glu Ile Leu Lys Asp Ser Leu Arg Glu Glu Met Asp Leu 
                165                 170                 175     


Leu Val Ile Arg Lys Thr Asp Glu Leu Arg Glu Lys Lys Lys Thr Asn 
            180                 185                 190         


Pro Lys Phe Lys Phe Ser Thr Asp Pro Thr Gln Ile Arg Asn Ser Ile 
        195                 200                 205             


Phe Asn Asp Ala Phe Gln Gly Leu Leu Tyr Glu Asp Lys Glu Asn Asn 
    210                 215                 220                 


Gly Lys Thr Gln Val Ser Tyr Arg Ala Lys Thr Lys Leu Asn Pro Lys 
225                 230                 235                 240 


Asp Ile His Lys Gln Glu Glu Arg Asp Phe Glu Ile Pro Leu Ser Thr 
                245                 250                 255     


Ser Gly Ile Val Phe Leu Met Ser Leu Phe Leu Ser Lys Lys Glu Ile 
            260                 265                 270         


Glu Asp Phe Lys Ser Asn Ile Lys Gly Phe Lys Gly Lys Val Val Lys 
        275                 280                 285             


Asp Glu Asn His Asn Ser Leu Lys Tyr Met Ala Thr His Arg Val Tyr 
    290                 295                 300                 


Ser Ile Leu Ala Phe Lys Gly Leu Lys Tyr Arg Ile Lys Thr Asp Thr 
305                 310                 315                 320 


Phe Ser Lys Val Thr Leu Met Met Gln Met Ile Asp Glu Leu Ser Lys 
                325                 330                 335     


Val Pro Asp Cys Val Tyr Gln Asn Leu Ser Glu Thr Lys Gln Lys Asp 
            340                 345                 350         


Phe Ile Glu Asp Trp Asn Glu Tyr Leu Lys Asp Asn Glu Glu Asn Thr 
        355                 360                 365             


Glu Asn Leu Glu Asn Ser Arg Val Val His Pro Leu Ile Arg Lys Arg 
    370                 375                 380                 


Tyr Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe 
385                 390                 395                 400 


Ala Asn Phe Lys Thr Leu Lys Phe Gln Val Phe Met Gly Tyr Tyr Ile 
                405                 410                 415     


His Asp Gln Arg Thr Lys Thr Ile Gly Thr Thr Asn Ile Thr Thr Glu 
            420                 425                 430         


Arg Thr Val Lys Glu Lys Ile Asn Val Phe Gly Lys Leu Ser Lys Met 
        435                 440                 445             


Asp Asn Leu Lys Lys His Phe Phe Ser Gln Leu Ser Asp Glu Glu Asn 
    450                 455                 460                 


Thr Asp Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Phe Leu Thr Gln 
465                 470                 475                 480 


Ala Asp Asn Ser Pro Ala Asn Asn Ile Pro Ile Tyr Leu Glu Leu Lys 
                485                 490                 495     


Asn Gln Gln Ile Ile Lys Glu Lys Asp Asp Ile Lys Ala Glu Val Asn 
            500                 505                 510         


Asn Ser Gln Asn Arg Asn Pro Asn Lys Pro Ser Lys Arg Asp Leu Leu 
        515                 520                 525             


Asn Lys Ile Ser Asn Thr Asn Glu Asp Phe Tyr Gln Gly Asp Pro Thr 
    530                 535                 540                 


Ala Ile Leu Ser Leu Asn Glu Ile Pro Ala Leu Leu His Leu Phe Leu 
545                 550                 555                 560 


Val Gln Pro Asp Asn Lys Thr Gly Gln Gln Ile Glu Asn Ile Ile Arg 
                565                 570                 575     


Ile Lys Ile Glu Lys Gln Phe Asn Ser Ile Lys Asn Pro Ser Lys Asp 
            580                 585                 590         


Asp Lys Gly Val Pro Lys Ser Leu Phe Ala Asp Thr Asn Val Arg Val 
        595                 600                 605             


Asn Ala Ile Lys Leu Lys Lys Asp Leu Gly Glu Glu Leu Asp Met Leu 
    610                 615                 620                 


Asn Lys Lys Gln Ile Val Phe Lys Glu Asn Gln Lys Ala Ser Ser Asn 
625                 630                 635                 640 


Tyr Asp Glu Leu Leu Lys Lys His Gln Phe Thr Pro Lys Asn Lys Arg 
                645                 650                 655     


Pro Ala Leu Arg Lys Tyr Val Phe Tyr Asn Ser Glu Lys Gly Glu Glu 
            660                 665                 670         


Ala Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Lys Gly Phe 
        675                 680                 685             


Lys Thr Lys Trp Lys Gly Tyr Gln His Ser Glu Leu Gln Arg Lys Leu 
    690                 695                 700                 


Ala Phe Tyr Asp Arg His Thr Lys Gln Asp Ile Lys Glu Leu Leu Ser 
705                 710                 715                 720 


Gly Cys Glu Phe Asp His Phe Leu Leu Asp Ile Asn Ala Cys Phe Lys 
                725                 730                 735     


Glu Asp Asp Phe Glu Asp Phe Phe Ser Lys Tyr Leu Lys Asn Arg Ile 
            740                 745                 750         


Glu Thr Leu Asn Ile Ile Leu Lys Gln Leu His Asp Phe Lys Asn Glu 
        755                 760                 765             


Pro Thr Pro Leu Lys Gly Val Phe Lys Asn Cys Leu Lys Phe Leu Lys 
    770                 775                 780                 


Gln Lys Asn Tyr Val Thr Glu Asn Pro Glu Ile Ile Lys Lys Arg Ile 
785                 790                 795                 800 


Leu Ala Lys Pro Ala Phe Leu Pro Arg Gly Ile Phe Asp Glu Arg Pro 
                805                 810                 815     


Thr Met Lys Lys Gly Lys Asn Pro Leu Ile Asp Arg Asp Glu Phe Ala 
            820                 825                 830         


Lys Trp Phe Val Glu Tyr Leu Glu Asn Lys Asp Tyr Gln Lys Phe Tyr 
        835                 840                 845             


Asn Ser Glu Glu Tyr Arg Ile Arg Asp Ala Asp Phe Lys Lys Asn Ala 
    850                 855                 860                 


Val Ile Lys Lys Gln Lys Leu Lys Asp Phe Tyr Thr Leu Gln Met Val 
865                 870                 875                 880 


Asn Tyr Leu Leu Lys Glu Val Phe Gly Lys Asp Glu Met Asn Leu Gln 
                885                 890                 895     


Leu Ser Glu Leu Phe Gln Thr Arg Gln Glu Arg Leu Lys Leu Gln Gly 
            900                 905                 910         


Ile Ala Lys Lys Gln Met Asn Lys Glu Thr Gly Asp Ser Ser Glu Asn 
        915                 920                 925             


Thr Arg Asn Gln Thr Tyr Ile Trp Asn Lys Asp Val Pro Val Ser Phe 
    930                 935                 940                 


Phe Asn Gly Lys Val Thr Ile Asp Lys Val Lys Leu Lys Asn Ile Gly 
945                 950                 955                 960 


Lys Tyr Lys Arg Tyr Glu Arg Asp Glu Arg Val Lys Thr Phe Ile Gly 
                965                 970                 975     


Tyr Glu Val Asp Glu Lys Trp Met Met Tyr Leu Pro His Asn Trp Lys 
            980                 985                 990         


Asp Arg Tyr Ser Val Lys Pro Ile  Asn Val Ile Asp Leu  Gln Ile Gln 
        995                 1000                 1005             


Glu Tyr  Glu Glu Ile Arg Ser  His Glu Leu Leu Lys  Glu Ile Gln 
    1010                 1015                 1020             


Asn Leu  Glu Gln Tyr Ile Tyr  Asp His Thr Thr Asp  Lys Asn Thr 
    1025                 1030                 1035             


Leu Leu  Gln Asp Gly Asn Pro  Asn Phe Lys Met Tyr  Val Leu Asn 
    1040                 1045                 1050             


Gly Leu  Leu Thr Gly Ile Lys  Gln Val Asn Ile Ala  Asp Phe Ile 
    1055                 1060                 1065             


Val Leu  Lys Gln Asn Thr Asn  Phe Asp Lys Ile Asp  Phe Thr Gly 
    1070                 1075                 1080             


Ile Ala  Ser Cys Ser Glu Leu  Glu Lys Lys Thr Ile  Ile Leu Ile 
    1085                 1090                 1095             


Ala Ile  Arg Asn Lys Phe Ala  His Asn Gln Leu Pro  Asn Lys Thr 
    1100                 1105                 1110             


Ile Tyr  Asp Leu Ala Asn Glu  Phe Leu Lys Lys Glu  Lys Arg Glu 
    1115                 1120                 1125             


Thr Tyr  Ala Asn Tyr Tyr Leu  Lys Val Leu Lys Lys  Met Ile Ser 
    1130                 1135                 1140             


Asp Leu  Ala 
    1145     


<210>  2151
<211>  1146
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2151

Met Glu Ser Ile Ile Gly Leu Gly Leu Ser Phe Asn Pro Tyr Lys Thr 
1               5                   10                  15      


Ala Asp Lys His Tyr Phe Gly Ser Phe Leu Asn Leu Ala Asp Asn Asn 
            20                  25                  30          


Leu Lys Ala Val Phe Ala Glu Phe Lys Glu Arg Ile Ser Asp Lys Ser 
        35                  40                  45              


Lys Asp Glu Asp Ile Ser Asn Leu Ile Glu Lys His Phe Ile Asp Asn 
    50                  55                  60                  


Met Ser Ile Val Asp Tyr Glu Lys Asn Ile Ser Ile Leu Asn Gly Tyr 
65                  70                  75                  80  


Leu Pro Ile Ile Asp Phe Leu Asp Asp Glu Leu Glu Asn Asn Leu Asn 
                85                  90                  95      


Thr Arg Val Lys Asn Phe Lys Lys Ser Phe Ile Ile Leu Ala Glu Ala 
            100                 105                 110         


Leu Glu Thr Leu Arg Asn Tyr Tyr Thr His Phe Tyr His Asp Pro Ile 
        115                 120                 125             


Thr Phe Gly Asp Asn Lys Glu Pro Leu Leu Glu Leu Leu Asp Glu Val 
    130                 135                 140                 


Leu Leu Lys Thr Ile Leu Asp Val Lys Lys Lys Tyr Leu Lys Thr Asp 
145                 150                 155                 160 


Lys Thr Lys Glu Ile Leu Lys Asp Ser Leu Arg Glu Glu Met Asp Leu 
                165                 170                 175     


Leu Val Ile Arg Lys Thr Asp Glu Leu Arg Glu Lys Lys Lys Thr Asn 
            180                 185                 190         


Pro Lys Phe Lys Phe Ser Thr Asp Pro Thr Gln Ile Arg Asn Ser Ile 
        195                 200                 205             


Phe Asn Asp Ala Phe Gln Gly Leu Leu Tyr Glu Asp Lys Glu Asn Asn 
    210                 215                 220                 


Gly Lys Thr Gln Val Ser Tyr Arg Ala Lys Thr Lys Leu Asn Pro Lys 
225                 230                 235                 240 


Asp Ile His Lys Gln Glu Glu Arg Asp Phe Glu Ile Pro Leu Ser Thr 
                245                 250                 255     


Ser Gly Ile Val Phe Leu Met Ser Leu Phe Leu Ser Lys Lys Glu Ile 
            260                 265                 270         


Glu Asp Phe Lys Ser Asn Ile Lys Gly Phe Lys Gly Lys Val Val Lys 
        275                 280                 285             


Asp Glu Asn His Asn Ser Leu Lys Tyr Met Ala Thr His Arg Val Tyr 
    290                 295                 300                 


Ser Ile Leu Ala Phe Lys Gly Leu Lys Tyr Arg Ile Lys Thr Asp Thr 
305                 310                 315                 320 


Phe Ser Lys Val Thr Leu Met Met Gln Met Ile Asp Glu Leu Ser Lys 
                325                 330                 335     


Val Pro Asp Cys Val Tyr Gln Asn Leu Ser Glu Thr Lys Gln Lys Asp 
            340                 345                 350         


Phe Ile Glu Asp Trp Asn Glu Tyr Leu Lys Asp Asn Glu Glu Asn Thr 
        355                 360                 365             


Glu Asn Leu Glu Asn Ser Arg Val Val His Pro Leu Ile Arg Lys Arg 
    370                 375                 380                 


Tyr Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe 
385                 390                 395                 400 


Ala Asn Phe Lys Thr Leu Lys Phe Gln Val Phe Met Gly Tyr Tyr Ile 
                405                 410                 415     


His Asp Gln Arg Thr Lys Thr Ile Gly Thr Thr Asn Ile Thr Thr Glu 
            420                 425                 430         


Arg Thr Val Lys Glu Lys Ile Asn Val Phe Gly Lys Leu Ser Lys Met 
        435                 440                 445             


Asp Asn Leu Lys Lys His Phe Phe Ser Gln Leu Ser Asp Glu Glu Asn 
    450                 455                 460                 


Thr Asp Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Phe Leu Thr Gln 
465                 470                 475                 480 


Ala Asp Asn Ser Pro Ala Asn Asn Ile Pro Ile Tyr Leu Glu Leu Lys 
                485                 490                 495     


Asn Gln Gln Ile Ile Lys Glu Lys Asp Asp Ile Lys Ala Glu Val Asn 
            500                 505                 510         


Asn Ser Gln Asn Arg Asn Pro Asn Lys Pro Ser Lys Arg Asp Leu Leu 
        515                 520                 525             


Asn Lys Ile Ser Asn Thr Asn Glu Asp Phe Tyr Gln Gly Asp Pro Thr 
    530                 535                 540                 


Ala Ile Leu Ser Leu Asn Glu Ile Pro Ala Leu Leu His Leu Phe Leu 
545                 550                 555                 560 


Val Gln Pro Asp Asn Lys Thr Gly Gln Gln Ile Glu Asn Ile Ile Arg 
                565                 570                 575     


Ile Lys Ile Glu Lys Gln Phe Asn Ser Ile Lys Asn Pro Ser Lys Asp 
            580                 585                 590         


Asp Lys Gly Val Pro Lys Ser Leu Phe Ala Asp Thr Asn Val Arg Val 
        595                 600                 605             


Asn Ala Ile Lys Leu Lys Lys Asp Leu Gly Glu Glu Leu Asp Met Leu 
    610                 615                 620                 


Asn Lys Lys Gln Ile Val Phe Lys Glu Asn Gln Lys Ala Ser Ser Asn 
625                 630                 635                 640 


Tyr Asp Glu Leu Leu Lys Lys His Gln Phe Thr Pro Lys Asn Lys Arg 
                645                 650                 655     


Pro Ala Leu Arg Lys Tyr Val Phe Tyr Asn Ser Glu Lys Gly Glu Glu 
            660                 665                 670         


Ala Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Lys Gly Phe 
        675                 680                 685             


Lys Thr Lys Trp Lys Gly Tyr Gln His Ser Glu Leu Gln Arg Lys Leu 
    690                 695                 700                 


Ala Phe Tyr Asp Arg His Thr Lys Gln Asp Ile Lys Glu Leu Leu Ser 
705                 710                 715                 720 


Gly Cys Glu Phe Asp His Phe Leu Leu Asp Ile Asn Ala Cys Phe Lys 
                725                 730                 735     


Glu Asp Asp Phe Glu Asp Phe Phe Ser Lys Tyr Leu Lys Asn Arg Ile 
            740                 745                 750         


Glu Thr Leu Asn Ile Ile Leu Lys Gln Leu His Asp Phe Lys Asn Glu 
        755                 760                 765             


Pro Thr Pro Leu Lys Gly Val Phe Lys Asn Cys Leu Lys Phe Leu Lys 
    770                 775                 780                 


Gln Lys Asn Tyr Val Thr Glu Asn Pro Glu Ile Ile Lys Lys Arg Ile 
785                 790                 795                 800 


Leu Ala Lys Pro Ala Phe Leu Pro Arg Gly Ile Phe Asp Glu Arg Pro 
                805                 810                 815     


Thr Met Lys Lys Gly Lys Asn Pro Leu Ile Asp Arg Asp Glu Phe Ala 
            820                 825                 830         


Lys Trp Phe Val Glu Tyr Leu Glu Asn Lys Asp Tyr Gln Lys Phe Tyr 
        835                 840                 845             


Asn Ser Glu Glu Tyr Arg Ile Arg Asp Ala Asp Phe Lys Lys Asn Ala 
    850                 855                 860                 


Val Ile Lys Lys Gln Lys Leu Lys Asp Phe Tyr Thr Leu Gln Met Val 
865                 870                 875                 880 


Asn Tyr Leu Leu Lys Glu Val Phe Gly Lys Asp Glu Met Asn Leu Gln 
                885                 890                 895     


Leu Ser Glu Leu Phe Gln Thr Arg Gln Glu Arg Leu Lys Leu Gln Gly 
            900                 905                 910         


Ile Ala Lys Lys Gln Met Asn Lys Glu Thr Gly Asp Ser Ser Glu Asn 
        915                 920                 925             


Thr Arg Asn Gln Thr Tyr Ile Trp Asn Lys Asp Val Pro Val Ser Phe 
    930                 935                 940                 


Phe Asn Gly Lys Val Thr Ile Asp Lys Val Lys Leu Lys Asn Ile Gly 
945                 950                 955                 960 


Lys Tyr Lys Arg Tyr Glu Arg Asp Glu Arg Val Lys Thr Phe Ile Gly 
                965                 970                 975     


Tyr Glu Val Asp Glu Lys Trp Met Met Tyr Leu Pro His Asn Trp Lys 
            980                 985                 990         


Asp Arg Tyr Ser Val Lys Pro Ile  Asn Val Ile Asp Leu  Gln Ile Gln 
        995                 1000                 1005             


Glu Tyr  Glu Glu Ile Arg Ser  His Glu Leu Leu Lys  Glu Ile Gln 
    1010                 1015                 1020             


Asn Leu  Glu Gln Tyr Ile Tyr  Asp His Thr Thr Asp  Lys Asn Thr 
    1025                 1030                 1035             


Leu Leu  Gln Asp Gly Asn Pro  Asn Phe Lys Met Tyr  Val Leu Asn 
    1040                 1045                 1050             


Gly Leu  Leu Thr Gly Ile Lys  Gln Val Asn Ile Ala  Asp Phe Ile 
    1055                 1060                 1065             


Val Leu  Lys Gln Asn Thr Asn  Phe Asp Lys Ile Asp  Phe Thr Gly 
    1070                 1075                 1080             


Ile Ala  Ser Cys Ser Glu Leu  Glu Lys Lys Thr Ile  Ile Leu Ile 
    1085                 1090                 1095             


Ala Ile  Arg Asn Lys Phe Ala  His Asn Gln Leu Pro  Asn Lys Thr 
    1100                 1105                 1110             


Ile Tyr  Asp Leu Ala Asn Glu  Phe Leu Lys Lys Glu  Lys Arg Glu 
    1115                 1120                 1125             


Thr Tyr  Ala Asn Tyr Tyr Leu  Lys Val Leu Lys Lys  Met Ile Ser 
    1130                 1135                 1140             


Asp Leu  Ala 
    1145     


<210>  2152
<211>  1085
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2152

Met Asn Ala Gln Thr Val Leu Asp His Ile Gln Lys Val Thr Glu Leu 
1               5                   10                  15      


Pro Ile Ile Pro Ala Ile Asn Lys Glu Gly Lys Glu Phe Thr Pro Pro 
            20                  25                  30          


Glu Glu Asp Leu Trp Gln His Pro Val Met Arg Tyr Ile Asn His Val 
        35                  40                  45              


Ala Tyr Lys Gln Asp Asp Gln Pro Glu Lys Thr Gln Ala Val Ile Glu 
    50                  55                  60                  


Lys Leu Leu His His Phe Ser Phe Leu Lys Ile Met Ala Glu Asn Gln 
65                  70                  75                  80  


Arg Asp Tyr Trp Asn Lys Lys Asn Asn Thr His Arg Leu Glu Val Asn 
                85                  90                  95      


Ser Thr Asp Leu Asn Gly Ile Leu Asn Thr Val Phe Arg Val Ile Lys 
            100                 105                 110         


Lys Tyr Arg Asp Thr Thr Thr His Tyr Met Thr Asn Asp Thr Cys Trp 
        115                 120                 125             


Asn Asp Gly Ser Asp Phe Leu Ala Lys Glu Gln Arg Leu Ala Phe Met 
    130                 135                 140                 


Ile Asp Asn Tyr Tyr Glu Val Ala Leu Arg Asp Leu Lys Glu Arg Tyr 
145                 150                 155                 160 


Ser Tyr Thr Thr Asp Asp Leu Arg Phe Ile Gln Tyr Tyr Arg Tyr Lys 
                165                 170                 175     


Arg Val Arg Met Pro Asp Gly Lys Pro Thr Met Cys Lys Asn Thr Asn 
            180                 185                 190         


Phe Tyr Leu Ser Met Val Asp Tyr Asn Gly Asp Ala Gly Lys Lys Leu 
        195                 200                 205             


His Leu Ser Gly Val Gly Val Ala Gln Leu Val Cys Leu Phe Leu Asp 
    210                 215                 220                 


Lys Gln Tyr Ile Asn Gln Leu Ala Ser Asn Leu Glu Leu Thr Ser Lys 
225                 230                 235                 240 


His Leu Pro Ser Ser Lys Glu Ala Gln Ile Ile Arg Arg Ser Leu Gly 
                245                 250                 255     


Ile His Asn Ile Val Leu Pro Lys Asp Arg Ile His Ser Asp Lys Gly 
            260                 265                 270         


Glu Met Ser Ile Ala Met Asp Met Leu Gly Glu Ile Lys Arg Cys Pro 
        275                 280                 285             


Asn Glu Leu Phe Asp Thr Leu Ser Ala Asp Arg Gln Ser Ser Phe Arg 
    290                 295                 300                 


Leu Ile Ser Ser Asp His Asn Glu Val Leu Leu Lys Arg Ser Ser Asp 
305                 310                 315                 320 


Arg Phe Ala Gln Leu Thr Leu Gln Tyr Ile Asp Tyr Gly Glu Lys Phe 
                325                 330                 335     


Asp Arg Ile Arg Phe His Val Asn Met Gly Lys Leu Arg Tyr Leu Phe 
            340                 345                 350         


Asn Ala Glu Lys Thr Cys Val Asp Gly Gln Val Arg Val Arg Val Ile 
        355                 360                 365             


Glu His Pro Leu Asn Gly Phe Gly Arg Met Ala Glu Met Glu Ala Met 
    370                 375                 380                 


Arg Lys Gln Glu Asp Gly Thr Phe Gly Lys Thr Gly Ile Gln Ile Arg 
385                 390                 395                 400 


Asp Phe Asp Asn Val Lys Arg Asp Asp Ala Asn Pro Ala Asn Tyr Pro 
                405                 410                 415     


Tyr Ile Val Asp Thr Tyr Thr His Tyr Met Leu Asp Asp Asn His Val 
            420                 425                 430         


Glu Met Leu Ile Gly Lys Pro Met Asp Met Pro Glu Ile Glu Glu Tyr 
        435                 440                 445             


Asp Gly Lys Trp Tyr Val Asn Lys Thr Val Pro Ser Cys Arg Met Ser 
    450                 455                 460                 


Thr Leu Glu Leu Pro Ala Met Met Phe His Met His Leu Leu Gly Ser 
465                 470                 475                 480 


Lys Arg Thr Glu Ala Arg Ile Ile Asp Phe Tyr Glu Arg Tyr Cys Lys 
                485                 490                 495     


Leu Phe Asp Ala Leu Lys Gln Gly Ala Val Ser Lys Glu Asn Ile Gly 
            500                 505                 510         


Glu Phe Gly Ile Lys Glu Gln Asp Met Pro Gln Lys Val Leu Asp Val 
        515                 520                 525             


Ile Asn Gly Asn Ala Gln Gly Lys Asn Ala Asn Glu Tyr Ile Leu Lys 
    530                 535                 540                 


Thr Leu Gln Glu Leu Tyr Asp His Ala Cys Lys Arg Ile Asp Asn Leu 
545                 550                 555                 560 


Arg Gln Asp Lys Arg Ala Ile Gly Ser Ala Ala Asn Lys Met Gly Lys 
                565                 570                 575     


Arg Gly Tyr Arg Gln Ile Lys Pro Gly Lys Leu Ala Glu Tyr Leu Ile 
            580                 585                 590         


Gln Asp Ile Val Arg Trp Gln Pro Thr Leu Ser Ala Gly Asp Asp Tyr 
        595                 600                 605             


Gly Thr Asp Arg Leu Thr Gly Leu Asn Tyr Arg Val Met Gln Ala Ala 
    610                 615                 620                 


Ile Ala Thr Tyr Asp Ser Arg Gly Lys Asp Glu Glu Ala Arg Arg Phe 
625                 630                 635                 640 


Lys Ala Met Phe Glu Arg Ala Asn Leu Ile Gly Gly Asp Arg Gln Lys 
                645                 650                 655     


Asn His Pro Phe Leu Tyr Lys Val Phe Gly Tyr Arg Leu Pro Ala Asp 
            660                 665                 670         


Ile Val Asp Phe Tyr Glu Lys Tyr Leu Asn Glu Gln Lys Tyr Tyr Ile 
        675                 680                 685             


Asn Ser Leu Leu Lys Lys Ala Lys Gln Gly Glu Val Val Asn Val Pro 
    690                 695                 700                 


Phe Val Asn Arg Asp Gln Ser Lys Trp Lys Lys Pro Thr Gln Glu Tyr 
705                 710                 715                 720 


Leu Gly Ala Glu Tyr Met Ala Asp Lys Ala Ile Glu Leu Pro Arg Gln 
                725                 730                 735     


Met Phe Asp Glu Asp Ile Lys Asn His Leu Lys Thr Leu Asp Gln Met 
            740                 745                 750         


Lys Asp Val Asp Phe Asp His Ala Asn Val Thr Tyr Leu Ile Gly Glu 
        755                 760                 765             


Tyr Met Lys Arg Val Arg Asp Asp Ala Phe Gln Glu Phe Tyr Ala Trp 
    770                 775                 780                 


Arg Arg Asn Tyr Arg Tyr Ile Asp Leu Leu Lys Cys Glu Val Asp Arg 
785                 790                 795                 800 


Thr Lys Arg Ile Pro Lys Leu Val Glu Thr Trp Thr Thr Thr Glu Glu 
                805                 810                 815     


Arg Glu Lys Ile Trp Lys Glu Arg Glu Lys Leu Ala Lys Glu Tyr Arg 
            820                 825                 830         


Ser Trp Ala Asp Gly Gln Met Lys Asn Asn Pro Gln Thr Arg Arg Leu 
        835                 840                 845             


Thr Glu Asp Glu Arg Gly Glu Ile Ile Ala Lys Arg Leu Ser Asn Ser 
    850                 855                 860                 


Arg Asn Asp Tyr Gln Arg Ser Glu Lys Met Ile Arg Arg Tyr Lys Val 
865                 870                 875                 880 


Gln Asp Ala Leu Leu Phe Ile Ala Ala Asn Asp Thr Leu Thr Gln His 
                885                 890                 895     


Met Asp Phe Lys Gly Lys Gln Phe Lys Leu Lys Asp Ile Thr Pro Asp 
            900                 905                 910         


Ala Glu Arg Gly Ile Leu Ser Glu Lys Met Ser Met Asp Phe Lys Phe 
        915                 920                 925             


Glu Lys Asn Gly Lys Thr Tyr Ile Ile Tyr Ala Gln Glu Met Lys Ile 
    930                 935                 940                 


Lys Asn Tyr Gly Asp Phe Phe Val Leu Ala Asn Asp Lys Arg Leu Val 
945                 950                 955                 960 


Asn Leu Leu Ala Leu Val Asn Gln Asp Arg Val Ser Lys Asp Glu Ile 
                965                 970                 975     


Glu Gln Glu Leu Lys Arg Tyr Asp Val Cys Arg Pro Glu Val Val Lys 
            980                 985                 990         


Met Ile Leu Asp Leu Glu Lys Trp  Ala Phe Asp Asn Phe  Pro Glu Leu 
        995                 1000                 1005             


Lys Ala  Lys Val Met Asn Asp  Arg Glu Asp Asn Lys  Val Gly Phe 
    1010                 1015                 1020             


Asn Tyr  Ile Leu Asp Val Leu  Leu Glu Asn Lys Arg  Ile Gly Glu 
    1025                 1030                 1035             


Ala Gln  Lys Glu Thr Leu Arg  Leu Ile Arg Asn Ala  Phe Asp His 
    1040                 1045                 1050             


Asn Asn  Tyr Pro Arg Thr Gly  Val Val Asn Val Val  Thr Leu Pro 
    1055                 1060                 1065             


Glu Ile  Ala Glu Glu Met Arg  Asp Leu Phe Gly Glu  Tyr Ala Arg 
    1070                 1075                 1080             


Ile Glu  
    1085 


<210>  2153
<211>  1277
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2153

Met Ser Tyr Gln Asn Arg Asp Asn Leu Lys Lys Ser Lys Ala Pro Phe 
1               5                   10                  15      


Ser Ile Asp Thr Val Gly Lys Ala Pro Ile Gly Ala Tyr Phe Asn Leu 
            20                  25                  30          


Ala Arg Tyr Asn Phe Tyr Arg Thr Ile Val Asp Ile Tyr Asn Lys Val 
        35                  40                  45              


Gly Phe Ala Val Asn Phe Asp Glu Glu Lys Phe Ala Lys Ala Leu Phe 
    50                  55                  60                  


Ala Leu Tyr Arg Val Thr Ile Gly Lys Lys Asn Glu Met Pro Gln Asn 
65                  70                  75                  80  


Gln Lys Asp Leu Val Asn Gly Ile Lys Leu Thr Thr Asp Lys Gln Glu 
                85                  90                  95      


Lys Leu Lys Arg Leu Leu Tyr Lys His Phe Pro Phe Ile Asp Pro Ile 
            100                 105                 110         


Leu Ala Gly Glu Val Asn Arg Pro Lys Ser Lys Lys Ser Asn Val Ala 
        115                 120                 125             


Asn Asp Glu Glu Gln Met Ala Gly Val Thr Leu Ser Gln Val Leu Lys 
    130                 135                 140                 


Val Val Ala Asn Met Ala Leu Thr Val His Asp Cys Arg Asn Tyr Tyr 
145                 150                 155                 160 


Thr His Tyr Asn Pro Tyr Asn Ser Glu Glu Asp Gln Met Tyr Gln Tyr 
                165                 170                 175     


Trp Arg Gln Gly Leu Val Ala His Tyr Leu Glu Arg Leu Phe Thr Ala 
            180                 185                 190         


Ala Arg Arg Ile Ser Lys Asn Arg Glu Arg Leu Thr Ser Val Glu Met 
        195                 200                 205             


Glu Phe Leu Thr Ser Leu Asn His Tyr Phe Lys Gln Arg Asn Glu Lys 
    210                 215                 220                 


Thr Gly Lys Phe Asp Ile Pro Val Glu Arg Asp Asp Tyr Tyr Phe Lys 
225                 230                 235                 240 


Ile Thr Gly Lys Arg Gln Val Val Asp Ala Ala Gly His Asp Val Glu 
                245                 250                 255     


Val Glu Asp Glu Glu Gly Asn Pro Ile Thr Phe Asn Lys Ala Leu Ser 
            260                 265                 270         


Asp Phe Gly Val Leu Tyr Leu Cys Ile Leu Phe Leu Asn Lys Thr Tyr 
        275                 280                 285             


Ala Arg Lys Leu Ile Asp Glu Met His Leu Leu Asp Gly Lys Arg Val 
    290                 295                 300                 


Gln Ile Gly Lys Ala Ile Arg Asn Lys Glu Thr Gly Arg Trp Glu Thr 
305                 310                 315                 320 


Phe Asp Ile Tyr Glu Gly Cys Pro Tyr Cys Thr Asp Lys Glu Lys Lys 
                325                 330                 335     


Ile Ile Ser Glu Ile Leu Ser Val Tyr Arg Ile Arg Val Pro His Gly 
            340                 345                 350         


Lys Arg Ile Asp Cys Asn Asp Arg Gly Met Gln Leu Ala Met Asp Ile 
        355                 360                 365             


Leu Asn Glu Leu Arg Lys Cys Pro Met Pro Leu Tyr Asp Leu Leu Thr 
    370                 375                 380                 


Pro Glu Gly Arg Arg Thr Phe Glu Asp Glu Val Gln Ala Arg Ser Gly 
385                 390                 395                 400 


Gln Val Asp Asp Lys Gly Asp Pro Ile Tyr Val Pro Thr Gly Asp Val 
                405                 410                 415     


Val Lys Arg Leu Arg His Asp Asp Arg Phe Ala His Leu Val Leu Lys 
            420                 425                 430         


Tyr Ile Asp Glu Lys Gln Leu Phe Ser Arg Ile Arg Phe Gln Val Arg 
        435                 440                 445             


Leu Gly Ala Tyr Arg Phe Lys Phe Tyr Asp Lys Thr Cys Val Asp Gly 
    450                 455                 460                 


Glu Thr Arg Leu Arg Arg Leu Gln Lys Asp Val Asn Gly Tyr Gly Arg 
465                 470                 475                 480 


Leu Gln Glu Ile Glu Ala Leu Lys Gln Glu Glu Tyr Lys Asp Met Leu 
                485                 490                 495     


Gln Gln Thr Gln Asp Val Asp Thr Val Leu Glu Asp Arg Glu Thr Thr 
            500                 505                 510         


Leu Asn Leu Glu Gln Phe Val Glu Asp Asp Ile Asn Ser Gln Pro Tyr 
        515                 520                 525             


Leu Thr Asp Ser Arg Ala Val Tyr Asn Ile His Asn Asn Arg Ile Gly 
    530                 535                 540                 


Met Leu Trp Asn Asp Glu Arg Asn Lys Gly Ala Met Lys Pro Asn Asn 
545                 550                 555                 560 


Gly Asn Pro Tyr Phe Leu Pro Asn Phe Ala Asp Gly Lys Gln Gly Val 
                565                 570                 575     


Val Gln Pro Gly Pro Leu Ala Ser Leu Ser Ile Tyr Asp Phe Pro Ala 
            580                 585                 590         


Met Val Leu Tyr Asp Ile Leu Arg Arg Pro Leu Glu Lys Asn Pro Asp 
        595                 600                 605             


Phe Pro Thr Thr Glu Gln Val Ile Ile Asp Lys His Asp Ala Leu Arg 
    610                 615                 620                 


Arg Phe Phe Asn Asp Val Tyr Ser Glu Asp Ile Phe Asp Arg Asp Thr 
625                 630                 635                 640 


Ala Gly Arg Val Val Leu Phe Ala Asn Glu Gln Ala Leu Ser Gln Arg 
                645                 650                 655     


Ile Gly Glu Arg Tyr Gly Leu Gln Leu Asn Glu Ile Pro Asp Lys Leu 
            660                 665                 670         


Lys Asp Gln Leu Val Lys Thr Arg Lys Pro Gln Glu Ser Gly His Gln 
        675                 680                 685             


Arg Met Leu Arg Leu Val Arg Ala Asp Leu Ser Asp Arg Ile Ser Gln 
    690                 695                 700                 


Val Glu Arg Lys Leu Glu Arg Tyr Arg Asp Thr Leu Arg Ala Val Gly 
705                 710                 715                 720 


Ser Ala Asp Asn Lys Tyr Gly Lys Lys Gln Tyr Val Asp Val Arg His 
                725                 730                 735     


Gly Thr Leu Ala Arg Arg Leu Ala Gly Ser Leu Ala Arg Trp Met Pro 
            740                 745                 750         


Arg Gly Ala Asp Gly Lys Thr Arg Leu Thr Gly Leu Asn Phe Asn Val 
        755                 760                 765             


Leu Thr Ser Thr Leu Ala Thr Phe Gly Ser Gly Thr Ser Tyr Gln Glu 
    770                 775                 780                 


Phe Tyr Glu Met Leu Glu Gln Ala Gly Leu Leu Ser Gly Asp His Ala 
785                 790                 795                 800 


His Pro Phe Leu Arg Arg Val Leu Glu Arg Gly Val Arg Asn Ile Glu 
                805                 810                 815     


Asp Leu Tyr Glu Lys Tyr Met Val Val Glu Ile Glu His Leu Asn Asn 
            820                 825                 830         


Val Leu Lys Asn Asn Asn Leu Gln Ser Leu Pro Phe Val His Pro Gln 
        835                 840                 845             


Arg Ala Arg Trp Ser Asp Arg Asn Tyr Lys Gln Leu Ala His Thr Tyr 
    850                 855                 860                 


Leu His Leu Thr Asp Asp Arg Asp Ala Thr Met Leu Leu Pro Asp Gly 
865                 870                 875                 880 


Leu Phe Ala Pro Trp Leu Lys Arg Ile Met Gln Phe Leu Phe Ala Asp 
                885                 890                 895     


Asn Gln Asp Val Met Asp Ala Leu Ser Asn Asp Gln Ala Cys Asn Ser 
            900                 905                 910         


Ala Ser Tyr Leu Ile Asn Ala Tyr Met Val Tyr Val Gln Glu Asp Glu 
        915                 920                 925             


Ala Gln Pro Phe Tyr Tyr Gly Ser Glu Gln Gln Pro Asp Ala Ile Phe 
    930                 935                 940                 


Asn Arg Ala Tyr Asp Leu Phe Thr Ile Leu Gln Asn Arg Arg Thr Arg 
945                 950                 955                 960 


Glu Arg Ser Tyr Val Pro Ala Tyr Leu Pro Glu Gly Glu Ile Met Asp 
                965                 970                 975     


Arg Leu Lys Glu Lys Thr Thr Asp Gly Lys Arg Lys Ile Met Ala Asp 
            980                 985                 990         


Ile Glu Ala Arg Ala Ser Lys Leu  Asp Lys Thr Asp Leu  Ala Pro Tyr 
        995                 1000                 1005             


Lys Lys  Pro Lys Asn Gly Leu  Ser Pro Arg Gln Gln  Ala Arg Glu 
    1010                 1015                 1020             


Ala Met  Ile Thr Lys Leu Lys  Arg Cys Tyr Lys Glu  Cys Gln Asn 
    1025                 1030                 1035             


Thr Glu  Arg Thr Ile Arg Arg  Tyr Met Thr Gln Asp  Ile Ile Leu 
    1040                 1045                 1050             


Phe Gln  Ile Ala Arg Glu Ile  Leu Ser Glu Met Ile  Asn Phe Gly 
    1055                 1060                 1065             


Asp Pro  Arg Asp Ser Ser Phe  Lys Leu Phe Asn Ile  Phe Glu Pro 
    1070                 1075                 1080             


Asn Phe  Leu Ser His Gly Val  Arg Val Glu Phe Lys  Val Glu Val 
    1085                 1090                 1095             


Phe Gln  Gly Lys Asn Lys Pro  Pro Arg Val Val Thr  Ile Tyr His 
    1100                 1105                 1110             


Asp Asn  Met Ala Leu Lys Asn  Tyr Gly Glu Ile Ser  Arg Leu Val 
    1115                 1120                 1125             


Asn Asp  Glu Arg Thr Leu Ser  Leu Leu Gln Gln Leu  Lys Asp Val 
    1130                 1135                 1140             


Asn Gln  Val Glu Tyr Thr Asp  Leu Cys Gly Glu Phe  Asp Phe Tyr 
    1145                 1150                 1155             


Asp Asn  Arg Arg Thr Ala Val  Phe Lys Ile Val Gln  Glu Ile Glu 
    1160                 1165                 1170             


Gln Leu  Ala Tyr Glu Arg Asn  Arg Leu Thr Leu Asn  Asp Val Asn 
    1175                 1180                 1185             


His Pro  Ala Phe Tyr Val Asp  Gly Asp Ser Ser Asn  Gln Ala Val 
    1190                 1195                 1200             


Arg Thr  Asn Phe Lys Ala Leu  Leu Asp Leu Leu Ser  Gln Glu Val 
    1205                 1210                 1215             


Thr Thr  Leu Ser Ala Asp Asp  Arg Asp Val Leu Arg  Gln Val Arg 
    1220                 1225                 1230             


Asn Ala  Phe Ser His Asn Ser  Tyr Asn Val Ala Leu  Glu Lys Leu 
    1235                 1240                 1245             


Gly Pro  Asn Ala Gln Ile Gln  Leu Pro Arg Val Ala  Lys Leu Ile 
    1250                 1255                 1260             


Ile Asp  His Ile Thr Thr Ile  Gln Ser Ser Ile Pro  Gln Glu 
    1265                 1270                 1275         


<210>  2154
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2154

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Leu Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2155
<211>  1146
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2155

Met Glu Ser Ile Ile Gly Leu Gly Leu Ser Phe Asn Pro Tyr Lys Thr 
1               5                   10                  15      


Ala Asp Lys His Tyr Phe Gly Ser Phe Leu Asn Leu Ala Asp Asn Asn 
            20                  25                  30          


Leu Lys Ala Val Phe Ala Glu Phe Lys Glu Arg Ile Ser Asp Lys Ser 
        35                  40                  45              


Lys Asp Glu Asp Ile Ser Asn Leu Ile Glu Lys His Phe Ile Asp Asn 
    50                  55                  60                  


Met Ser Ile Val Asp Tyr Glu Lys Asn Ile Ser Ile Leu Asn Gly Tyr 
65                  70                  75                  80  


Leu Pro Ile Ile Asp Phe Leu Asp Asp Glu Leu Glu Asn Asn Leu Asn 
                85                  90                  95      


Thr Arg Val Lys Asn Phe Lys Lys Ser Phe Ile Ile Leu Ala Glu Ala 
            100                 105                 110         


Leu Glu Thr Leu Arg Asn Tyr Tyr Thr His Phe Tyr His Asp Pro Ile 
        115                 120                 125             


Thr Phe Gly Asp Asn Lys Glu Pro Leu Leu Glu Leu Leu Asp Glu Val 
    130                 135                 140                 


Leu Leu Lys Thr Ile Leu Asp Val Lys Lys Lys Tyr Leu Lys Thr Asp 
145                 150                 155                 160 


Lys Thr Lys Glu Ile Leu Lys Asp Ser Leu Arg Glu Glu Met Asp Leu 
                165                 170                 175     


Leu Val Ile Arg Lys Thr Asp Glu Leu Arg Glu Lys Lys Lys Thr Asn 
            180                 185                 190         


Pro Lys Phe Lys Phe Ser Thr Asp Pro Thr Gln Ile Arg Asn Ser Ile 
        195                 200                 205             


Phe Asn Asp Ala Phe Gln Gly Leu Leu Tyr Glu Asp Lys Glu Asn Asn 
    210                 215                 220                 


Gly Lys Thr Gln Val Ser Tyr Arg Ala Lys Thr Lys Leu Asn Pro Lys 
225                 230                 235                 240 


Asp Ile His Lys Gln Glu Glu Arg Asp Phe Glu Ile Pro Leu Ser Thr 
                245                 250                 255     


Ser Gly Ile Val Phe Leu Met Ser Leu Phe Leu Ser Lys Lys Glu Ile 
            260                 265                 270         


Glu Asp Phe Lys Ser Asn Ile Lys Gly Phe Lys Gly Lys Val Val Lys 
        275                 280                 285             


Asp Glu Asn His Asn Ser Leu Lys Tyr Met Ala Thr His Arg Val Tyr 
    290                 295                 300                 


Ser Ile Leu Ala Phe Lys Gly Leu Lys Tyr Arg Ile Lys Thr Asp Thr 
305                 310                 315                 320 


Phe Ser Lys Val Thr Leu Met Met Gln Met Ile Asp Glu Leu Ser Lys 
                325                 330                 335     


Val Pro Asp Cys Val Tyr Gln Asn Leu Ser Glu Thr Lys Gln Lys Asp 
            340                 345                 350         


Phe Ile Glu Asp Trp Asn Glu Tyr Leu Lys Asp Asn Glu Glu Asn Thr 
        355                 360                 365             


Glu Asn Leu Glu Asn Ser Arg Val Val His Pro Leu Ile Arg Lys Arg 
    370                 375                 380                 


Tyr Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe 
385                 390                 395                 400 


Ala Asn Phe Lys Thr Leu Lys Phe Gln Val Phe Met Gly Tyr Tyr Ile 
                405                 410                 415     


His Asp Gln Arg Thr Lys Thr Ile Gly Thr Thr Asn Ile Thr Thr Glu 
            420                 425                 430         


Arg Thr Val Lys Glu Lys Ile Asn Val Phe Gly Lys Leu Ser Lys Met 
        435                 440                 445             


Asp Asn Leu Lys Lys His Phe Phe Ser Gln Leu Ser Asp Glu Glu Asn 
    450                 455                 460                 


Thr Asp Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Phe Leu Thr Gln 
465                 470                 475                 480 


Ala Asp Asn Ser Pro Ala Asn Asn Ile Pro Ile Tyr Leu Glu Leu Lys 
                485                 490                 495     


Asn Gln Gln Ile Ile Lys Glu Lys Asp Asp Ile Lys Ala Glu Val Asn 
            500                 505                 510         


Asn Ser Gln Asn Arg Asn Pro Asn Lys Pro Ser Lys Arg Asp Leu Leu 
        515                 520                 525             


Asn Lys Ile Ser Asn Thr Asn Glu Asp Phe Tyr Gln Gly Asp Pro Thr 
    530                 535                 540                 


Ala Ile Leu Ser Leu Asn Glu Ile Pro Ala Leu Leu His Leu Phe Leu 
545                 550                 555                 560 


Val Gln Pro Asp Asn Lys Thr Gly Gln Gln Ile Glu Asn Ile Ile Arg 
                565                 570                 575     


Ile Lys Ile Glu Lys Gln Phe Asn Ser Ile Lys Asn Pro Ser Lys Asp 
            580                 585                 590         


Asp Lys Gly Val Pro Lys Ser Leu Phe Ala Asp Thr Asn Val Arg Val 
        595                 600                 605             


Asn Ala Ile Lys Leu Lys Lys Asp Leu Gly Glu Glu Leu Asp Met Leu 
    610                 615                 620                 


Asn Lys Lys Gln Ile Val Phe Lys Glu Asn Gln Lys Ala Ser Ser Asn 
625                 630                 635                 640 


Tyr Asp Glu Leu Leu Lys Lys His Gln Phe Thr Pro Lys Asn Lys Arg 
                645                 650                 655     


Pro Ala Leu Arg Lys Tyr Val Phe Tyr Asn Ser Glu Lys Gly Glu Glu 
            660                 665                 670         


Ala Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Lys Gly Phe 
        675                 680                 685             


Lys Thr Lys Trp Lys Gly Tyr Gln His Ser Glu Leu Gln Arg Lys Leu 
    690                 695                 700                 


Ala Phe Tyr Asp Arg His Thr Lys Gln Asp Ile Lys Glu Leu Leu Ser 
705                 710                 715                 720 


Gly Cys Glu Phe Asp His Phe Leu Leu Asp Ile Asn Ala Cys Phe Lys 
                725                 730                 735     


Glu Asp Asp Phe Glu Asp Phe Phe Ser Lys Tyr Leu Lys Asn Arg Ile 
            740                 745                 750         


Glu Thr Leu Asn Ile Ile Leu Lys Gln Leu His Asp Phe Lys Asn Glu 
        755                 760                 765             


Pro Thr Pro Leu Lys Gly Val Phe Lys Asn Cys Leu Lys Phe Leu Lys 
    770                 775                 780                 


Gln Lys Asn Tyr Val Thr Glu Asn Pro Glu Ile Ile Lys Lys Arg Ile 
785                 790                 795                 800 


Leu Ala Lys Pro Ala Phe Leu Pro Arg Gly Ile Phe Asp Glu Arg Pro 
                805                 810                 815     


Thr Met Lys Lys Gly Lys Asn Pro Leu Ile Asp Arg Asp Glu Phe Ala 
            820                 825                 830         


Lys Trp Phe Val Glu Tyr Leu Glu Asn Lys Asp Tyr Gln Lys Phe Tyr 
        835                 840                 845             


Asn Ser Glu Glu Tyr Arg Ile Arg Asp Ala Asp Phe Lys Lys Asn Ala 
    850                 855                 860                 


Val Ile Lys Lys Gln Lys Leu Lys Asp Phe Tyr Thr Leu Gln Met Val 
865                 870                 875                 880 


Asn Tyr Leu Leu Lys Glu Val Phe Gly Lys Asp Glu Met Asn Leu Gln 
                885                 890                 895     


Leu Ser Glu Leu Phe Gln Thr Arg Gln Glu Arg Leu Lys Leu Gln Gly 
            900                 905                 910         


Ile Ala Lys Lys Gln Met Asn Lys Glu Thr Gly Asp Ser Ser Glu Asn 
        915                 920                 925             


Thr Arg Asn Gln Thr Tyr Ile Trp Asn Lys Asp Val Pro Val Ser Phe 
    930                 935                 940                 


Phe Asn Gly Lys Val Thr Ile Asp Lys Val Lys Leu Lys Asn Ile Gly 
945                 950                 955                 960 


Lys Tyr Lys Arg Tyr Glu Arg Asp Glu Arg Val Lys Thr Phe Ile Gly 
                965                 970                 975     


Tyr Glu Val Asp Glu Lys Trp Met Met Tyr Leu Pro His Asn Trp Lys 
            980                 985                 990         


Asp Arg Tyr Ser Val Lys Pro Ile  Asn Val Ile Asp Leu  Gln Ile Gln 
        995                 1000                 1005             


Glu Tyr  Glu Glu Ile Arg Ser  His Glu Leu Leu Lys  Glu Ile Gln 
    1010                 1015                 1020             


Asn Leu  Glu Gln Tyr Ile Tyr  Asp His Thr Thr Asp  Lys Asn Thr 
    1025                 1030                 1035             


Leu Leu  Gln Asp Gly Asn Pro  Asn Phe Lys Met Tyr  Val Leu Asn 
    1040                 1045                 1050             


Gly Leu  Leu Thr Gly Ile Lys  Gln Val Asn Ile Ala  Asp Phe Ile 
    1055                 1060                 1065             


Val Leu  Lys Gln Asn Thr Asn  Phe Asp Lys Ile Asp  Phe Thr Gly 
    1070                 1075                 1080             


Ile Ala  Ser Cys Ser Glu Leu  Glu Lys Lys Thr Ile  Ile Leu Ile 
    1085                 1090                 1095             


Ala Ile  Arg Asn Lys Phe Ala  His Asn Gln Leu Pro  Asn Lys Thr 
    1100                 1105                 1110             


Ile Tyr  Asp Leu Ala Asn Glu  Phe Leu Lys Lys Glu  Lys Arg Glu 
    1115                 1120                 1125             


Thr Tyr  Ala Asn Tyr Tyr Leu  Lys Val Leu Lys Lys  Met Ile Ser 
    1130                 1135                 1140             


Asp Leu  Ala 
    1145     


<210>  2156
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2156

Leu Gln Lys Gln Asp Lys Leu Phe Val Asp Arg Lys Lys Asn Ala Ile 
1               5                   10                  15      


Phe Ala Phe Pro Lys Tyr Ile Thr Ile Met Glu Asn Lys Glu Lys Thr 
            20                  25                  30          


Glu Pro Ile Tyr Tyr Glu Leu Thr Asp Lys His Phe Trp Ala Ala Phe 
        35                  40                  45              


Leu Asn Leu Ala Arg His Asn Val Tyr Thr Thr Val Asn His Ile Asn 
    50                  55                  60                  


Lys Leu Leu Glu Ile Ala Glu Leu Lys Asn Asp Glu Asp Val Leu Asn 
65                  70                  75                  80  


Ile Lys Asp Ser Trp Asn Lys Gln Ala Glu Lys Leu Asp Lys Lys Val 
                85                  90                  95      


Arg Leu Arg Asp Leu Ile Met Lys His Phe Pro Phe Leu Glu Ala Ala 
            100                 105                 110         


Ala Tyr Glu Ile Thr Asn Ser Lys Ser Pro Asn Asn Lys Glu Gln Arg 
        115                 120                 125             


Glu Lys Glu Gln Ser Glu Ala Leu Ser Leu Asn Asn Leu Lys Asn Val 
    130                 135                 140                 


Leu Phe Ile Phe Leu Glu Lys Leu Gln Val Leu Arg Asn Tyr Tyr Ser 
145                 150                 155                 160 


His Tyr Lys Tyr Ser Glu Glu Ser Pro Lys Pro Ile Phe Glu Thr Ser 
                165                 170                 175     


Leu Leu Lys Asn Met Tyr Lys Val Phe Asp Ala Asn Val Arg Leu Val 
            180                 185                 190         


Lys Arg Asp Tyr Met His His Glu Asn Ile Asp Met Gln Arg Asp Phe 
        195                 200                 205             


Thr His Leu Asn Arg Lys Lys Gln Val Gly Arg Thr Lys Asn Ile Ile 
    210                 215                 220                 


Asp Ser Pro Asn Phe His Tyr His Phe Ala Asp Lys Glu Gly Asn Met 
225                 230                 235                 240 


Thr Ile Ala Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Asp Lys Lys 
                245                 250                 255     


Asp Ala Ile Trp Met Gln Lys Lys Leu Lys Gly Phe Lys Asp Gly Arg 
            260                 265                 270         


Asn Leu Arg Glu Gln Met Thr Asn Glu Val Phe Cys Arg Ser Arg Ile 
        275                 280                 285             


Ser Leu Pro Lys Leu Lys Leu Glu Asn Val Gln Thr Lys Asp Trp Met 
    290                 295                 300                 


Gln Leu Asp Met Leu Asn Glu Leu Val Arg Cys Pro Lys Ser Leu Tyr 
305                 310                 315                 320 


Glu Arg Leu Arg Glu Lys Asp Arg Glu Ser Phe Lys Val Pro Phe Asp 
                325                 330                 335     


Ile Phe Ser Asp Asp Tyr Asp Ala Glu Glu Glu Pro Phe Lys Asn Thr 
            340                 345                 350         


Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe 
        355                 360                 365             


Asp Leu Asn Glu Ile Phe Glu Gln Leu Arg Phe Gln Ile Asp Leu Gly 
    370                 375                 380                 


Thr Tyr His Phe Ser Ile Tyr Asn Lys Leu Ile Gly Asp Glu Asp Glu 
385                 390                 395                 400 


Val Arg His Leu Thr His His Leu Tyr Gly Phe Ala Arg Ile Gln Asp 
                405                 410                 415     


Phe Ala Pro Gln Asn Gln Pro Glu Glu Trp Arg Lys Leu Val Lys Asp 
            420                 425                 430         


Leu Asp His Phe Glu Thr Ser Gln Lys Pro Tyr Ile Ser Lys Thr Ala 
        435                 440                 445             


Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Lys Phe Cys Ser 
    450                 455                 460                 


Thr His Asn Asn Leu Phe Pro Ser Leu Lys Arg Glu Lys Thr Cys Asn 
465                 470                 475                 480 


Gly Arg Ser Lys Phe Asn Leu Gly Thr Gln Phe Thr Ala Glu Ala Phe 
                485                 490                 495     


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu 
            500                 505                 510         


Thr Lys Asp Tyr Ser Arg Lys Glu Ser Ala Asp Lys Val Glu Gly Ile 
        515                 520                 525             


Ile Arg Lys Glu Ile Ser Asn Ile Tyr Ala Ile Tyr Asp Ala Phe Ala 
    530                 535                 540                 


Asn Gly Glu Ile Asn Ser Ile Ala Asp Leu Thr Cys Arg Leu Gln Lys 
545                 550                 555                 560 


Thr Asn Ile Leu Gln Gly His Leu Pro Lys Gln Met Ile Ser Ile Leu 
                565                 570                 575     


Glu Gly Arg Gln Lys Asp Met Glu Lys Glu Ala Glu Arg Lys Ile Gly 
            580                 585                 590         


Glu Met Ile Asp Asp Thr Gln Arg Arg Leu Asp Leu Leu Cys Lys Gln 
        595                 600                 605             


Thr Asn Gln Lys Ile Arg Ile Gly Lys Arg Asn Ala Gly Leu Leu Lys 
    610                 615                 620                 


Ser Gly Lys Ile Ala Asp Trp Leu Val Asn Asp Met Met Arg Phe Gln 
625                 630                 635                 640 


Pro Val Gln Lys Asp Gln Asn Asn Ile Pro Ile Asn Asn Ser Lys Ala 
                645                 650                 655     


Asn Ser Thr Glu Tyr Arg Met Leu Gln Arg Ala Leu Ala Leu Phe Gly 
            660                 665                 670         


Ser Glu Asn Phe Arg Leu Lys Ala Tyr Phe Asn Gln Met Asn Leu Val 
        675                 680                 685             


Gly Asn Asp Asn Pro His Pro Phe Leu Ala Glu Thr Gln Trp Glu His 
    690                 695                 700                 


Gln Thr Asn Ile Leu Ser Phe Tyr Arg Asn Tyr Leu Glu Ala Arg Lys 
705                 710                 715                 720 


Lys Tyr Leu Lys Gly Leu Lys Pro Gln Asn Trp Lys Gln Tyr Gln His 
                725                 730                 735     


Phe Leu Ile Leu Lys Val Gln Lys Thr Asn Arg Asn Thr Leu Val Thr 
            740                 745                 750         


Gly Trp Lys Asn Ser Phe Asn Leu Pro Arg Gly Ile Phe Thr Gln Pro 
        755                 760                 765             


Ile Arg Glu Trp Phe Glu Lys His Asn Asn Ser Lys Arg Ile Tyr Asp 
    770                 775                 780                 


Gln Ile Leu Ser Phe Gly Arg Val Gly Phe Val Ala Lys Ala Ile Pro 
785                 790                 795                 800 


Leu Tyr Phe Ala Glu Glu Cys Lys Asp Cys Val Gln Pro Phe Tyr Asp 
                805                 810                 815     


Tyr Pro Phe Asn Val Gly Asn Lys Leu Lys Pro Lys Lys Gly Gln Phe 
            820                 825                 830         


Leu Asp Lys Lys Asp Arg Val Glu Leu Trp Gln Lys Asn Lys Glu Leu 
        835                 840                 845             


Phe Lys Asn Tyr Pro Pro Glu Lys Arg Lys Thr Asp Leu Ala Tyr Leu 
    850                 855                 860                 


Asp Phe Leu Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys 
865                 870                 875                 880 


Asn Gln Asp Ile Val Thr Trp Leu Met Phe Lys Glu Leu Phe Lys Thr 
                885                 890                 895     


Thr Thr Val Glu Gly Leu Lys Ile Gly Glu Ile His Leu Arg Asp Ile 
            900                 905                 910         


Asp Thr Asn Thr Ala Asn Glu Glu Ser Asn Asn Ile Leu Asn Arg Ile 
        915                 920                 925             


Met Pro Met Lys Leu Pro Val Lys Thr Tyr Glu Thr Asp Asn Lys Gly 
    930                 935                 940                 


Asn Ile Leu Lys Glu Arg Pro Leu Ala Thr Phe Tyr Ile Glu Glu Thr 
945                 950                 955                 960 


Glu Thr Lys Val Leu Lys Gln Gly Asn Phe Lys Val Leu Ala Lys Asp 
                965                 970                 975     


Arg Arg Leu Asn Gly Leu Leu Ser Phe Ala Glu Thr Thr Asp Ile Asp 
            980                 985                 990         


Leu Glu Lys Asn Pro Ile Thr Lys  Leu Ser Val Asp His  Glu Leu Ile 
        995                 1000                 1005             


Lys Tyr  Gln Thr Thr Arg Ile  Ser Ile Phe Glu Met  Thr Leu Gly 
    1010                 1015                 1020             


Leu Glu  Lys Lys Leu Ile Asp  Lys Tyr Ser Thr Leu  Pro Thr Asp 
    1025                 1030                 1035             


Ser Phe  Arg Asn Met Leu Glu  Arg Trp Leu Gln Cys  Lys Ala Asn 
    1040                 1045                 1050             


Arg Pro  Glu Leu Lys Asn Tyr  Val Asn Ser Leu Ile  Ala Val Arg 
    1055                 1060                 1065             


Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met Tyr Asp  Ala Thr Leu 
    1070                 1075                 1080             


Phe Ala  Glu Val Lys Lys Phe  Thr Leu Phe Pro Ser  Val Asp Thr 
    1085                 1090                 1095             


Lys Lys  Ile Glu Leu Asn Ile  Ala Pro Gln Leu Leu  Glu Ile Val 
    1100                 1105                 1110             


Gly Lys  Ala Ile Lys Glu Ile  Glu Lys Ser Glu Asn  Lys Asn 
    1115                 1120                 1125         


<210>  2157
<211>  1119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2157

Met Lys Glu Glu Glu Thr Pro Val Val Ser Thr Tyr Asn Lys Asp Asp 
1               5                   10                  15      


Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val Tyr 
            20                  25                  30          


Ile Thr Ile Asn His Ile Asn Lys Leu Leu Glu Ile Arg Glu Ile Asp 
        35                  40                  45              


Asn Asp Glu Lys Val Leu Asp Ile Lys Thr Leu Trp Gln Lys Val Asn 
    50                  55                  60                  


Lys Asp Leu Asn Gln Lys Ala Arg Leu Arg Glu Leu Met Thr Lys His 
65                  70                  75                  80  


Phe Pro Phe Leu Glu Thr Ala Ile Tyr Thr Arg Asn Lys Glu Asp Lys 
                85                  90                  95      


Lys Glu Val Lys Glu Glu Lys Gln Ala Lys Ala Gln Ser Phe Asp Ser 
            100                 105                 110         


Leu Asn His Cys Leu Phe Leu Phe Leu Glu Lys Leu Gln Glu Ala Arg 
        115                 120                 125             


Asn Tyr Tyr Ser His Tyr Lys Tyr Ser Glu Ser Thr Lys Glu Pro Val 
    130                 135                 140                 


Leu Glu Lys Glu Leu Leu Lys Lys Met Tyr Asn Ile Phe Asp Asn Asn 
145                 150                 155                 160 


Ile Gln Leu Val Ile Lys Asp Tyr Gln His Asn Lys Asp Ile Asn Pro 
                165                 170                 175     


Asp Glu Asp Phe Lys His Leu Asp Arg Thr Glu Lys Glu Phe Asn Tyr 
            180                 185                 190         


Tyr Phe Thr Gln Asp Lys Lys Gly Lys Ile Thr Glu Ser Gly Leu Leu 
        195                 200                 205             


Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Met Gln 
    210                 215                 220                 


Gln Lys Phe Thr Gly Phe Lys Asp Asn Arg Glu Asn Asn Lys Gln Met 
225                 230                 235                 240 


Thr His Glu Val Phe Cys Arg Ser Arg Met Leu Leu Pro Lys Leu Arg 
                245                 250                 255     


Leu Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu Asn 
            260                 265                 270         


Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Lys Gly Glu 
        275                 280                 285             


Asp Arg Lys Lys Phe Glu Val Pro Phe Asp Ser Thr Asp Glu Asp Tyr 
    290                 295                 300                 


Asp Ala Glu Gln Asp Pro Phe Lys Asn Thr Leu Ile Arg His Gln Asp 
305                 310                 315                 320 


Arg Phe Pro Tyr Phe Ile Leu Arg Tyr Phe Asp Tyr Asn Glu Ile Phe 
                325                 330                 335     


Lys Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile 
            340                 345                 350         


Tyr Lys Lys Leu Ile Gly Gly Gln Lys Glu Tyr Arg His Leu Thr His 
        355                 360                 365             


Lys Leu Tyr Gly Phe Glu Arg Ile Gln Glu Phe Thr Lys Gln His Arg 
    370                 375                 380                 


Pro Asp Asp Trp Lys Ala Ile Val Lys Asp Phe Asp Thr Tyr Glu Thr 
385                 390                 395                 400 


Ser Glu Glu Pro Tyr Ile Ser Glu Thr Thr Pro His Tyr His Leu Glu 
                405                 410                 415     


Asn Gln Lys Ile Gly Ile Arg Phe Lys Asn Asp Asn Asp Lys Ile Trp 
            420                 425                 430         


Pro Ser Leu Glu Thr Asn Gly Glu Asn Asn Glu Lys Ser Lys Tyr Lys 
        435                 440                 445             


Leu Asp Lys Gln Tyr Gln Ala Glu Ala Phe Leu Ser Val His Glu Leu 
    450                 455                 460                 


Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Lys Lys Glu Glu Pro Asn 
465                 470                 475                 480 


Asn Asp Lys Lys Asn Ala Ser Arg Val Glu Gly Phe Ile Lys Arg Glu 
                485                 490                 495     


Ile Arg Asp Ile Phe Lys Leu Tyr Asp Ala Phe Ala Asn Asp Glu Ile 
            500                 505                 510         


Asn Asn Ile Asp Asp Leu Lys Lys Tyr Tyr Lys Asp Lys Asn Val Glu 
        515                 520                 525             


Ile Arg His Leu Pro Lys Gln Met Ile Ala Ile Leu Glu Ser Lys Pro 
    530                 535                 540                 


Lys Asp Met Ala Lys Glu Ala Lys Arg Lys Gln Lys Glu Met Val Lys 
545                 550                 555                 560 


Asp Thr Lys Lys Leu Leu Ala Thr Leu Glu Lys Gln Thr Gln Lys Glu 
                565                 570                 575     


Lys Glu Asp Glu Gly Arg Asn Val Lys Leu Leu Lys Ser Gly Glu Ile 
            580                 585                 590         


Ala Arg Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln Lys 
        595                 600                 605             


Asp Asn Glu Gly Lys Pro Gln Asn Asn Ser Lys Ala Asn Ser Thr Glu 
    610                 615                 620                 


Tyr Gln Met Leu Gln Arg Ser Leu Ala Leu Tyr Asn Lys Glu Glu Lys 
625                 630                 635                 640 


Pro Thr Arg Tyr Phe Arg Gln Val Asn Leu Ile Glu Ser Ser Asn Pro 
                645                 650                 655     


His Pro Phe Leu Lys Trp Thr Lys Trp Glu Glu Cys Asn Asn Ile Leu 
            660                 665                 670         


Thr Phe Tyr His Arg Tyr Leu Thr Lys Arg Ile Glu Phe Leu Asn Lys 
        675                 680                 685             


Leu Lys Pro Glu Asp Trp Lys Lys Asn Gln Tyr Phe Leu Lys Val Lys 
    690                 695                 700                 


Glu Pro Lys Thr Asn Arg Glu Thr Leu Val Gln Gly Trp Lys Asn Ser 
705                 710                 715                 720 


Phe Asn Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg Glu Trp Phe 
                725                 730                 735     


Glu Arg His Gln Asn Asp Ser Glu Glu Tyr Lys Lys Val Glu Lys Leu 
            740                 745                 750         


Asn Lys Ala Gly Leu Val Thr Lys Val Ile Pro Leu Phe Phe Lys Glu 
        755                 760                 765             


Glu Pro Phe Lys Glu Asn Thr Lys Lys Glu Ile Asn Asp Trp Val Gln 
    770                 775                 780                 


Pro Phe Tyr Ser Phe Pro Tyr Asn Val Gly Asn Ile His Lys Pro Lys 
785                 790                 795                 800 


Glu Glu Asp Phe Leu His Arg Glu Glu Arg Ile Glu Leu Trp Asp Lys 
                805                 810                 815     


Lys Lys Asp Lys Phe Lys Gly Tyr Lys Glu Lys Ile Lys Ser Lys Lys 
            820                 825                 830         


Leu Thr Glu Lys Glu Lys Glu Glu Phe Arg Ser Tyr Leu Glu Phe Gln 
        835                 840                 845             


Ser Trp Asn Lys Phe Glu Arg Glu Leu Arg Leu Val Arg Asn Gln Asp 
    850                 855                 860                 


Ile Val Thr Trp Leu Leu Cys Lys Glu Leu Ile Asp Lys Leu Lys Ile 
865                 870                 875                 880 


Asp Glu Leu Asn Ile Glu Glu Leu Lys Lys Leu Arg Leu Asn Asn Ile 
                885                 890                 895     


Asp Thr Asp Thr Ala Lys Lys Glu Lys Asn Asn Ile Leu Asn Arg Val 
            900                 905                 910         


Met Pro Met Glu Leu Pro Val Thr Val Tyr Glu Val Ser Lys Ala Gly 
        915                 920                 925             


Asn Ile Ile Lys Asp Lys Pro Leu His Thr Ile Tyr Ile Lys Glu Ser 
    930                 935                 940                 


Lys Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys Asp 
945                 950                 955                 960 


Arg Arg Leu Asn Gly Leu Phe Ser Phe Val Lys Thr Asn Ser Glu Ala 
                965                 970                 975     


Glu Ser Lys Arg Asn Pro Ile Ser Lys Leu Arg Val Glu His Glu Leu 
            980                 985                 990         


Arg Glu Tyr Gln Lys Ala Arg Ile  Glu Ile Ile Lys Asp  Met Leu Val 
        995                 1000                 1005             


Leu Glu  Lys Thr Leu Ile Asp  Asn Tyr Asp Ser Leu  Asp Thr Asp 
    1010                 1015                 1020             


Asn Phe  His Asn Met Leu Thr  Gly Trp Leu Glu Leu  Lys Gly Glu 
    1025                 1030                 1035             


Val Asn  Lys Ala Lys Phe Asn  Asn Asp Val Lys Leu  Leu Thr Ala 
    1040                 1045                 1050             


Val Arg  Asn Ala Phe Ser His  Asn Gln Tyr Pro Met  Tyr Asp Glu 
    1055                 1060                 1065             


Asn Leu  Phe Val Asn Ile Glu  Arg Phe Ser Leu Ser  Ser Ser Lys 
    1070                 1075                 1080             


Ile Leu  Glu Ser Lys Gly Leu  Ser Ile Ala Val Lys  Leu Lys Glu 
    1085                 1090                 1095             


Glu Val  Ser Lys Ile Ile Lys  Lys Ile Gln Glu Glu  Glu Asp Gly 
    1100                 1105                 1110             


Lys Lys  Glu Lys Glu Thr 
    1115                 


<210>  2158
<211>  1103
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2158

Met Glu Lys Pro Leu Pro Pro Asn Val Tyr Thr Leu Lys His Lys Phe 
1               5                   10                  15      


Phe Trp Gly Ala Phe Leu Asn Ile Ala Arg His Asn Ala Phe Ile Thr 
            20                  25                  30          


Ile Cys His Ile Asn Glu Gln Leu Gly Leu Thr Thr Pro Pro Asn Asp 
        35                  40                  45              


Asp Lys Ile Ala Asp Val Val Cys Gly Thr Trp Asn Asn Ile Leu Asn 
    50                  55                  60                  


Asn Asp His Asp Leu Leu Lys Lys Ser Gln Leu Thr Glu Leu Ile Leu 
65                  70                  75                  80  


Lys His Phe Pro Phe Leu Ala Ala Met Cys Tyr His Pro Pro Lys Lys 
                85                  90                  95      


Glu Gly Lys Lys Lys Gly Ser Gln Lys Glu Gln Gln Lys Glu Lys Glu 
            100                 105                 110         


Asn Glu Ala Gln Ser Gln Ala Glu Ala Leu Asn Pro Ser Glu Leu Ile 
        115                 120                 125             


Lys Ala Leu Lys Thr Leu Val Lys Gln Leu Arg Thr Leu Arg Asn Tyr 
    130                 135                 140                 


Tyr Ser His Tyr Lys His Lys Lys Pro Asp Ala Glu Lys Asp Ile Phe 
145                 150                 155                 160 


Lys His Leu Tyr Lys Ala Phe Asp Ala Ser Leu Arg Met Val Lys Glu 
                165                 170                 175     


Asp Tyr Lys Ala His Phe Thr Val Asn Leu Thr Gln Asp Phe Ala His 
            180                 185                 190         


Leu Asn Arg Lys Gly Lys Asn Lys Gln Asp Asn Pro Lys Phe Asp Arg 
        195                 200                 205             


Tyr Arg Phe Glu Lys Asp Gly Phe Phe Thr Glu Ser Gly Leu Leu Phe 
    210                 215                 220                 


Phe Thr Asn Leu Phe Leu Asp Lys Arg Asp Ala Tyr Trp Met Leu Lys 
225                 230                 235                 240 


Lys Val Ser Gly Phe Lys Ala Ser His Lys Gln Ser Glu Lys Met Thr 
                245                 250                 255     


Thr Glu Val Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu 
            260                 265                 270         


Glu Ser Arg Tyr Asp His Asn Gln Met Leu Leu Asp Met Leu Ser Glu 
        275                 280                 285             


Leu Ser Arg Cys Pro Lys Leu Leu Tyr Glu Lys Leu Ser Glu Lys Asp 
    290                 295                 300                 


Lys Lys His Phe Gln Val Glu Ala Asp Gly Phe Leu Asp Glu Ile Glu 
305                 310                 315                 320 


Glu Glu Gln Asn Pro Phe Lys Asp Ala Leu Ile Arg His Gln Asp Arg 
                325                 330                 335     


Phe Pro Tyr Phe Ala Leu Arg Tyr Leu Asp Leu Asn Glu Ser Phe Lys 
            340                 345                 350         


Ser Ile Arg Phe Gln Val Asp Leu Gly Thr Tyr His Tyr Cys Ile Tyr 
        355                 360                 365             


Asp Lys Lys Ile Gly Asp Glu Gln Glu Lys Arg His Leu Thr Arg Thr 
    370                 375                 380                 


Leu Leu Ser Phe Gly Arg Leu Gln Asp Phe Thr Glu Ile Asn Arg Pro 
385                 390                 395                 400 


Gln Glu Trp Lys Ala Leu Thr Lys Asp Leu Asp Tyr Lys Glu Thr Ser 
                405                 410                 415     


Lys Gln Pro Phe Ile Ser Lys Thr Thr Pro His Tyr His Ile Thr Asp 
            420                 425                 430         


Asn Lys Ile Gly Phe Arg Leu Gly Thr Ser Lys Glu Leu Tyr Pro Ser 
        435                 440                 445             


Leu Glu Val Lys Asp Gly Ala Asn Arg Ile Ala Lys Tyr Pro Tyr Asn 
    450                 455                 460                 


Ser Asp Phe Val Ala His Ala Phe Ile Ser Val His Glu Leu Leu Pro 
465                 470                 475                 480 


Leu Met Phe Tyr Gln His Leu Thr Gly Lys Ser Glu Asp Leu Leu Lys 
                485                 490                 495     


Glu Thr Val Arg His Ile Gln Arg Ile Tyr Lys Asp Phe Glu Glu Glu 
            500                 505                 510         


Arg Ile Asn Thr Ile Glu Asp Leu Glu Lys Ala Asn Gln Gly Arg Leu 
        515                 520                 525             


Pro Leu Gly Ala Phe Pro Lys Gln Met Leu Gly Leu Leu Gln Asn Lys 
    530                 535                 540                 


Gln Pro Asp Leu Ser Glu Lys Ala Lys Ile Lys Ile Glu Lys Leu Ile 
545                 550                 555                 560 


Ala Glu Thr Lys Leu Leu Ser His Arg Leu Asn Thr Lys Leu Lys Ser 
                565                 570                 575     


Ser Pro Lys Leu Gly Lys Arg Arg Glu Lys Leu Ile Lys Thr Gly Asp 
            580                 585                 590         


Trp Leu Val Lys Asp Phe Met Arg Phe Gln Pro Val Ala Tyr Asp Val 
        595                 600                 605             


Gln Asn Gln Pro Ile Glu Ser Ser Lys Ala Asn Ser Thr Glu Phe Gln 
    610                 615                 620                 


Leu Ile Gln Arg Ala Leu Ala Leu Tyr Gly Gly Glu Lys Asn Arg Leu 
625                 630                 635                 640 


Glu Gly Tyr Phe Lys Gln Thr Asn Leu Ile Gly Asn Thr Asn Pro His 
                645                 650                 655     


Pro Phe Leu Asn Lys Phe Asn Trp Lys Ala Cys Arg Asn Leu Val Asp 
            660                 665                 670         


Phe Tyr Gln Gln Tyr Leu Glu Gln Arg Glu Lys Phe Leu Glu Ala Ile 
        675                 680                 685             


Lys Asn Gln Pro Trp Glu Pro Tyr Gln Tyr Cys Leu Leu Leu Lys Ile 
    690                 695                 700                 


Pro Lys Glu Asn Arg Lys Asn Leu Val Lys Gly Trp Glu Gln Gly Gly 
705                 710                 715                 720 


Ile Ser Leu Pro Arg Gly Leu Phe Thr Glu Ala Ile Arg Glu Thr Leu 
                725                 730                 735     


Ser Glu Asp Leu Thr Leu Ser Lys Pro Ile Arg Lys Glu Ile Lys Lys 
            740                 745                 750         


His Gly Arg Val Gly Phe Ile Ser Arg Ala Ile Thr Leu Tyr Phe Arg 
        755                 760                 765             


Glu Arg Tyr Gln Asp Asp His Gln Ser Phe Tyr Asn Leu Pro Tyr Glu 
    770                 775                 780                 


Leu Glu Ala Lys Ala Ser Thr Pro Lys Pro Pro Leu Pro Lys Lys Arg 
785                 790                 795                 800 


Glu Tyr Val Leu Arg Ala Glu His Tyr Glu Tyr Trp Gln Gln Asn Lys 
                805                 810                 815     


Pro Gln Ser Pro Thr Glu Leu Gln Arg Leu Glu Leu His Thr Ser Asp 
            820                 825                 830         


Arg Trp Lys Asp Tyr Leu Leu Tyr Lys Arg Trp Gln His Leu Glu Lys 
        835                 840                 845             


Lys Leu Arg Leu Tyr Arg Asn Gln Asp Val Met Leu Trp Leu Met Thr 
    850                 855                 860                 


Leu Glu Leu Thr Lys Asn His Phe Lys Glu Leu Lys Leu Asn Tyr His 
865                 870                 875                 880 


Gln Leu Lys Leu Glu Asn Leu Ala Val Asn Val Gln Glu Ala Asp Ala 
                885                 890                 895     


Lys Leu Asn Pro Leu Asn Gln Thr Leu Pro Met Val Leu Pro Val Lys 
            900                 905                 910         


Val Tyr Pro Ala Thr Ala Phe Gly Glu Val Gln Tyr Gln Glu Thr Pro 
        915                 920                 925             


Ile Arg Thr Val Tyr Ile Arg Glu Glu Gln Thr Lys Ala Leu Lys Met 
    930                 935                 940                 


Gly Asn Phe Lys Ala Leu Val Lys Asp Arg Arg Leu Asn Gly Leu Phe 
945                 950                 955                 960 


Ser Phe Ile Lys Glu Glu Asn Asp Thr Gln Lys His Pro Ile Ser Gln 
                965                 970                 975     


Leu Arg Leu Arg Arg Glu Leu Glu Ile Tyr Gln Ser Leu Arg Val Asp 
            980                 985                 990         


Ala Phe Lys Glu Thr Leu Ser Leu  Glu Glu Lys Leu Leu  Asn Lys His 
        995                 1000                 1005             


Ala Ser  Leu Ser Ser Leu Glu  Asn Glu Phe Arg Thr  Leu Leu Glu 
    1010                 1015                 1020             


Glu Trp  Lys Lys Lys Tyr Ala  Ala Ser Ser Met Val  Thr Asp Glu 
    1025                 1030                 1035             


His Ile  Ala Phe Ile Ala Ser  Val Arg Asn Ala Phe  Cys His Asn 
    1040                 1045                 1050             


Gln Tyr  Pro Phe Tyr Lys Glu  Thr Leu His Ala Pro  Ile Leu Leu 
    1055                 1060                 1065             


Phe Thr  Val Ala Gln Pro Thr  Thr Glu Glu Lys Asp  Gly Leu Gly 
    1070                 1075                 1080             


Ile Ala  Glu Ala Leu Leu Arg  Val Leu Arg Glu Tyr  Cys Glu Ile 
    1085                 1090                 1095             


Val Lys  Ser Gln Ile 
    1100             


<210>  2159
<211>  1141
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2159

Met Thr Gln Thr Ala Thr Thr Asn Ser Gly Thr Leu Ala Asp Asp Lys 
1               5                   10                  15      


Gln Thr Tyr Tyr Tyr His Phe Leu Lys Ser Asp Lys Phe Phe Phe Gly 
            20                  25                  30          


Ser Phe Phe Asn Leu Ala Asp Asn Asn Leu Lys Ala Thr Phe Asn Asp 
        35                  40                  45              


Phe Glu Lys Arg Leu Gly Ile Lys Ser Ala Asn Gly Leu Val Gln Lys 
    50                  55                  60                  


Val Glu Gln Tyr Phe Pro Asp Asn Leu Leu Leu Ser Glu Phe Glu Arg 
65                  70                  75                  80  


Arg Thr Glu Leu Leu Thr Glu Tyr Leu Pro Ile Val His Lys Leu Arg 
                85                  90                  95      


Lys Ile Asn Lys Glu Ser Ala Glu Pro Asp Arg Ser Tyr Phe Arg Asp 
            100                 105                 110         


Asn Leu Lys Met Leu Ile Lys Ala Val Asp His Leu Arg Asn Phe Tyr 
        115                 120                 125             


Thr His Tyr Tyr His Lys Ser Ile Ile Phe Asp Glu Arg Leu Phe Glu 
    130                 135                 140                 


Phe Leu Asn Gly Ala Leu Leu Asn Val Cys Phe Asp Val Lys Lys Lys 
145                 150                 155                 160 


Arg Met Lys Ser Asp Thr Asn Lys Ala Phe Leu Lys Lys His Phe Glu 
                165                 170                 175     


Glu Asn Phe Ile Asn Lys Ser Lys Asp Lys Ile Lys Glu Ala Phe Asp 
            180                 185                 190         


Glu Ala Phe Ser His Leu Lys Val Ser Asn Asp Gly Lys Lys Phe Ser 
        195                 200                 205             


Leu Thr Lys Phe Tyr Gln Ala Lys Leu Ser His Lys Gln Lys Phe Ser 
    210                 215                 220                 


Val Lys Asn Asp Leu Ile Phe Asp Ile Thr Asn Ser Asp Phe Val Phe 
225                 230                 235                 240 


Leu Ser Asn Ser Gly Leu Leu Phe Leu Leu Ser Phe Phe Leu Arg Arg 
                245                 250                 255     


Glu Glu Gln Glu Gln Leu Leu Ser Lys Met Glu Gly Phe Lys Asn Gln 
            260                 265                 270         


Asn Glu Leu Asn Phe Ile Ala Thr Arg Trp Val Phe Thr His Lys Cys 
        275                 280                 285             


Phe Lys Gly Leu Lys Lys Thr Ile Lys Ser Ser Tyr Asp Lys Glu Thr 
    290                 295                 300                 


Leu Leu Met Gln Met Val Asp Glu Leu Ser Lys Cys Pro Asp Val Leu 
305                 310                 315                 320 


Tyr Lys Asn Leu Ser Asp Lys Gln Lys Gln Glu Phe Val Val Asp Val 
                325                 330                 335     


Asn Glu Phe Tyr Gln Glu Ala Lys Glu Gln Asn Glu Glu Asn Lys Leu 
            340                 345                 350         


Val Ser His Thr Ile Ile Arg Lys Arg Tyr Glu Asp Lys Phe Ala Tyr 
        355                 360                 365             


Phe Ala Leu Arg Phe Leu Asp Glu Phe Ala Asn Phe Pro Thr Leu Arg 
    370                 375                 380                 


Phe Gln Val Val Val Gly Asn Tyr Leu Gln Asn Glu Gln Glu Lys Gln 
385                 390                 395                 400 


Ile Lys Asn Thr Thr Thr Val Leu Lys Thr Asn Arg Gln Ile Lys Glu 
                405                 410                 415     


Arg Ile Lys Met Phe Gly Lys Leu Ser Thr Leu Ser Ser Lys Lys Ala 
            420                 425                 430         


Ala Tyr Phe Lys Ala Ile Leu Glu Asp Arg Thr Leu Thr Ala Glu Glu 
        435                 440                 445             


Lys Gly Leu Asp Pro Lys Trp Glu Ile Phe Pro Asn Pro Ser Tyr Gly 
    450                 455                 460                 


Phe Lys Gly Asn Asn Ile Pro Ile Tyr Ile Asn Lys Lys Gly Phe Lys 
465                 470                 475                 480 


Asn Met Leu Ser Val Asp Glu Ala Lys Val Arg Thr Asn Lys Asp Arg 
                485                 490                 495     


Ala Ala Lys Lys Asp Ile Ile Glu Lys Ile Phe Gly Lys Asp Asn Tyr 
            500                 505                 510         


Tyr Gly Lys Pro Ile Ala Tyr Leu Ser Leu Asn Glu Leu Pro Ala Leu 
        515                 520                 525             


Leu Tyr Glu Phe Leu Val Asn Gly Lys Asn Gly Val Asp Ile Glu Asn 
    530                 535                 540                 


Ile Ile Phe Asn Lys Ile Lys Gln Gln Val Val Ala Ile Lys Ala Ala 
545                 550                 555                 560 


Asp Lys Thr Asn Lys Gly Ile Pro Asn Lys Leu Arg Lys Ala Lys Glu 
                565                 570                 575     


Glu Asn Asp Tyr Asp Leu Asn Lys Leu Lys Gly Asn Ile Lys Asp Gln 
            580                 585                 590         


Ile Asp Glu Cys Asn Glu Lys Ile His Phe Ile Arg Thr Cys Arg Ala 
        595                 600                 605             


Ala Phe Asp Pro Asn Lys Thr Lys His Phe Phe Thr Leu Lys Gln Leu 
    610                 615                 620                 


Gly Asp Glu Ala Thr Trp Leu Ala Asp Asp Ile Lys Arg Phe Met Leu 
625                 630                 635                 640 


Pro Glu Ala Arg Lys Asn Trp Lys Ala Tyr Glu His Ser Glu Phe Gln 
                645                 650                 655     


Arg Leu Leu Ala Phe Tyr Lys Arg Phe Arg Lys Asp Ala Arg Gln Leu 
            660                 665                 670         


Leu Lys Asn Lys Trp Thr Met Asn Asp Thr Phe Gly Glu Met Val Lys 
        675                 680                 685             


Arg Cys Phe Ser Gln Val Glu Phe Asp Gln Phe Tyr Glu Met Tyr Leu 
    690                 695                 700                 


Ile Asp Lys Ile Glu Gln Leu Glu Val Tyr Lys Asn Gln Leu Asp Gly 
705                 710                 715                 720 


Glu Ala Ile Gln Ser His Pro Lys Leu Leu Lys Lys Val Leu Lys Glu 
                725                 730                 735     


Ile Phe Arg Tyr Phe Asn Glu Arg Leu Tyr Leu Ile Lys Pro Ala Gly 
            740                 745                 750         


Lys Gln Ile Glu Glu Leu Leu Lys His Pro Ile Asn Leu Pro Arg Gly 
        755                 760                 765             


Ile Phe Asp Asn Arg Pro Thr Tyr Ile Glu Asn Ala Asn His Thr Asp 
    770                 775                 780                 


His Lys Asp Gln Tyr Ala Ala Trp Phe Leu His Ile Thr Lys Asn Glu 
785                 790                 795                 800 


Asn Glu Leu Gln Gln Phe Tyr Ser Phe Ala Trp Asn Ile Asn Asn Asp 
                805                 810                 815     


Lys Thr Leu Asp Tyr Glu Lys Leu Thr Lys Glu Lys Met Lys Arg Leu 
            820                 825                 830         


Glu Lys Lys Arg Lys Arg Gln Gly Lys Thr Asn Gln Asn Phe Ser Gln 
        835                 840                 845             


Asn Asn Ser Ile Asn Phe Asn Asn Leu Lys Glu Lys Ile Lys Ile Arg 
    850                 855                 860                 


Leu Gln Lys Asp Ala Lys Ala Ala Ile Asn Lys Gln Ile Arg Ser Asp 
865                 870                 875                 880 


Val Phe Ile Lys Ala Met Ala Asp Tyr Val Phe Glu Lys Thr Phe Asp 
                885                 890                 895     


Lys Pro Tyr Gln Ile Pro Leu Asn Glu Ile Tyr Gln Asn Lys Ala Gln 
            900                 905                 910         


Lys Glu Gln Met Arg Asn Glu Ala Ala Ala Gln Gln Ser Arg Ala Glu 
        915                 920                 925             


Gly Asp Lys Ser Ser Asn Ile Tyr Asn Glu Thr Phe Ile Trp Asn Lys 
    930                 935                 940                 


Val Ile Ser Tyr Ser Ile Phe Gly Gly Lys Ile Lys Glu Glu Lys Leu 
945                 950                 955                 960 


Lys Leu Lys Asp Ile Gly Lys Phe Arg Ala Leu Glu Gln Asn Pro Lys 
                965                 970                 975     


Val Lys Ala Ile Val Thr Tyr Pro His Asn Asp Asp Trp Ser Lys Thr 
            980                 985                 990         


Glu Ile Glu Lys Glu Leu Thr Asn  Tyr Glu Arg Ile Arg  Ser Glu Thr 
        995                 1000                 1005             


Leu Leu  Lys Ser Val Gln Glu  Ile Glu Lys Lys Val  Leu Gln Lys 
    1010                 1015                 1020             


Leu Gln  Thr Gly Thr Val His  Pro Lys Ile Leu Glu  His Lys Gly 
    1025                 1030                 1035             


Asn Pro  Gln Phe Arg Lys Tyr  Val Val Glu Gly Phe  Leu Lys Asp 
    1040                 1045                 1050             


Met Ile  Ala Glu Pro Glu Leu  Thr Phe Phe Asn Asn  Asn Lys Thr 
    1055                 1060                 1065             


Ile Asp  Asn Phe Ser Ile Ser  Glu Val Glu Glu Gln  Ala Leu Leu 
    1070                 1075                 1080             


Ile Gln  Gln Ala Phe Tyr Leu  Ile Leu Ile Arg Asn  Lys Phe Ala 
    1085                 1090                 1095             


His Asn  Gln Leu Pro Asn Val  Ala Phe Phe Glu Ala  Met Ile Asn 
    1100                 1105                 1110             


Ile Ser  Gly Ile Glu Lys Arg  Asn Asp Asn Phe Ala  Ala Gln Leu 
    1115                 1120                 1125             


Asn Gln  Ile Phe Asp Thr Phe  Lys Ala Glu Ile Ile  Lys 
    1130                 1135                 1140     


<210>  2160
<211>  1213
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2160

Met Glu Lys Asn Ser Leu Gln Asp Thr Thr Arg Thr Lys Asp Asp Val 
1               5                   10                  15      


Leu Tyr Phe Gly Ser Tyr Leu Asn Met Gly Arg His Asn Val Tyr Leu 
            20                  25                  30          


Ile Ile Asn His Val Thr Glu Val Phe Lys His Leu Gly Phe Arg Lys 
        35                  40                  45              


Leu Asn Asp Asp Glu Asp Ile Trp Ser Glu Lys Glu Gln Val Asn Glu 
    50                  55                  60                  


Gly Asn Ile Leu Leu Asn Ile Phe Asp Pro Lys Lys Glu Lys Tyr Gln 
65                  70                  75                  80  


Asp Glu Arg Phe Arg Val Phe Asn Tyr Leu Ile Lys Arg His His Leu 
                85                  90                  95      


Pro Phe Leu Arg Ile Phe Thr Asn Gln Val Leu Asn Asp Ser Gly Glu 
            100                 105                 110         


Ile Gln Asn Pro Glu Lys Lys Asp Met Leu Ile Asp Phe Glu Gly Ala 
        115                 120                 125             


His Val Phe Ile Asn Lys Ile Phe Arg Glu Leu Asn Glu Phe Arg Asn 
    130                 135                 140                 


Ser Tyr Thr His Tyr Leu Ser Leu Ser Asn Glu Gly Thr Pro Leu Pro 
145                 150                 155                 160 


Lys Lys Leu Gln Ile Asn Val Glu Leu Ile Lys Asp Leu Lys Thr Leu 
                165                 170                 175     


Phe Tyr Tyr Ala Pro Glu Phe Ser Phe Ile Arg His Asn Val Leu Lys 
            180                 185                 190         


Gln Glu Ser Lys Glu Glu Tyr Glu Thr Lys Val Lys Ala Tyr Tyr Asn 
        195                 200                 205             


Asp Ile Arg Arg Lys Tyr Arg Leu Phe Glu Gly Asp Glu Ser Ala Gly 
    210                 215                 220                 


Lys Leu Thr Asp Gln Gly Leu Phe Phe Phe Val Asn Leu Phe Leu Glu 
225                 230                 235                 240 


Arg Ser Asn Ala Ile Lys Phe Leu Lys Arg Phe Arg Gly Phe Lys Asn 
                245                 250                 255     


Glu Thr Leu Pro Pro Phe Lys Ala Thr Ile Gln Ser Phe Thr Thr Tyr 
            260                 265                 270         


Ala Leu Lys Ile Pro Asp Val Arg Leu Asp Asn Asp Phe Pro Lys Gln 
        275                 280                 285             


Ala Leu Leu Met Glu Ile Leu Thr Glu Leu Asn Arg Cys Pro Lys Glu 
    290                 295                 300                 


Leu Tyr Gln Val Leu Gly Lys Glu Asp Lys Ala Lys Phe Asp Pro Lys 
305                 310                 315                 320 


Leu Glu Gln Ser Ala Ile Asn Asn Ile Leu Glu Asn Val Asn Tyr Asp 
                325                 330                 335     


Glu Leu Ser Asp Glu His Leu Glu Gln Ala Ile Lys Glu Leu Val Val 
            340                 345                 350         


Leu Lys Arg His Asp Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Leu 
        355                 360                 365             


Asp Glu Met Asn Leu Leu Ser Gln Ile Arg Phe Gln Val Tyr Leu Gly 
    370                 375                 380                 


Lys Val Glu Leu Lys Ser Tyr Phe Lys Asp Asp Leu Gly Ile Glu Arg 
385                 390                 395                 400 


Arg Ile Leu Lys Pro Ile Tyr Ala Phe Gly Lys Leu Ser Asp Phe Asp 
                405                 410                 415     


Asn Lys Glu Glu Asp Ile Leu Arg Glu Leu Lys Lys Asn Leu Pro Pro 
            420                 425                 430         


Asp Cys Gln Asp Ile His Trp Asp Gln Tyr Lys Pro His Tyr Asn Ile 
        435                 440                 445             


Ser Gln Asn Asn Ile Pro Phe Tyr Ile Phe Asn Asp Thr Asp Pro Lys 
    450                 455                 460                 


Val Leu Leu Pro Arg Leu Pro Ile Lys Gly Arg Gln Glu Asp Arg Tyr 
465                 470                 475                 480 


Ser Lys Lys Pro Ala Gly Phe Leu Ser Ile His Ser Leu Pro Lys Phe 
                485                 490                 495     


Val Ile Thr Phe Leu Val Pro Pro Leu Asp Arg Asn Gly Glu Lys Lys 
            500                 505                 510         


Ile Ile Glu Phe Val Lys Ser Thr Asn Gly Phe Ile Leu Asn Tyr Glu 
        515                 520                 525             


Asn Ile Glu Asn Leu Gln Asn Lys Ile Gln Tyr Ala Pro Glu Thr Phe 
    530                 535                 540                 


Thr Arg Arg Met Val Lys Asn Arg Thr Leu Leu Asn Lys Glu Lys Lys 
545                 550                 555                 560 


Val Cys Tyr Val Thr Lys Ser Glu Ile Glu Asp Leu Thr Lys Lys Cys 
                565                 570                 575     


Glu Ile Ser Phe Glu Asp Leu Met Lys Leu Ser Arg Glu Glu Leu Ser 
            580                 585                 590         


Lys Lys Tyr Lys Asn Leu Ser Pro Arg Glu Ile Glu Val Phe Ser Gln 
        595                 600                 605             


Tyr Lys Tyr Glu His Met Leu Ala Ser Arg Lys Glu Ile Leu Met Thr 
    610                 615                 620                 


Glu Val Tyr Asn Asn Leu Pro Asp Leu Asn Leu Glu Phe Lys Tyr Leu 
625                 630                 635                 640 


Pro Gly Lys Ile Arg Asp Lys Leu Leu Lys Ile Lys Thr Asp Glu Lys 
                645                 650                 655     


Lys Leu Ile Lys Asn Arg Ile Lys Ser Glu Ile Ser His Thr Arg Tyr 
            660                 665                 670         


Leu Val Lys Lys Ala Asp Asn Ala Ser Lys Thr Asn Thr Thr Leu Lys 
        675                 680                 685             


Leu Gly Glu Met Ala Thr Glu Leu Ala Arg Asp Ile Thr Arg Met Val 
    690                 695                 700                 


Ile Asp Glu Asn Ile Lys Lys Lys Ile Thr Asn Pro Tyr Ala Asn Arg 
705                 710                 715                 720 


Leu Gln Asn Leu Ile Ala Tyr Phe Ser Leu Asn Lys Asn Glu Ile Val 
                725                 730                 735     


Gln Leu Leu Met Asn Glu Leu Lys Leu Phe Asp Thr Ala Lys Gly His 
            740                 745                 750         


Val Phe Leu Thr Arg Glu Leu Ile Glu Lys Ser Thr Gly Val Leu Asp 
        755                 760                 765             


Phe Tyr Ile Asn Tyr Phe Asn Lys Lys Ile Glu Tyr Phe Asp Ala Thr 
    770                 775                 780                 


Phe Lys Val Phe Leu Ala Ser Pro Ser Glu Tyr Glu Phe Lys Lys Ala 
785                 790                 795                 800 


Leu Pro Leu Lys Tyr Val Asn Leu Ile Lys Lys Thr Phe Glu Phe Asp 
                805                 810                 815     


Thr Val Lys Trp Phe Ala His Lys Asn Asn Met Pro Val Asn Ile Pro 
            820                 825                 830         


Phe Asn Leu Phe Asp Asn Leu Ile Asn Asn Lys Leu Lys Tyr Lys Ile 
        835                 840                 845             


Arg Glu Asn Thr Val Lys Met Thr Phe Ser Lys Leu Leu Glu Ile Tyr 
    850                 855                 860                 


Val Lys Tyr Asp Cys Gln Pro Phe Tyr Lys Phe Asn Arg Glu Tyr Asn 
865                 870                 875                 880 


Ser Val Glu Lys Asp Gln Thr Glu Ser Ile Asn Ile Leu Leu Leu Ser 
                885                 890                 895     


Ser Lys Asp Ile Gln Lys Asn Phe Ser Lys Arg Ala Val Asp Asn Glu 
            900                 905                 910         


Lys Gln Ile Arg Phe Thr Gln Ala Lys Asp Arg Ile Leu Lys Leu Met 
        915                 920                 925             


Ile Glu Gln Leu Ile Val Asp Ser Gly Ser Val Ile Ser Asp Ile Asp 
    930                 935                 940                 


Phe Asn Leu Glu Asp Ile Tyr Pro Gly Ser Glu Gln Ser Ala Leu Asn 
945                 950                 955                 960 


Ser Pro Ala Glu Phe Arg His Lys Leu Lys Arg Gln Gly Asn Asn Gly 
                965                 970                 975     


Glu Glu Phe Leu Thr Val Val Ala Lys Asp Ser Glu Ser Gln Ile Arg 
            980                 985                 990         


Gln Ile Lys Glu Trp Gly Glu Leu  Pro Lys Ala Glu Arg  Lys Ile Trp 
        995                 1000                 1005             


Asn Asn  Leu Lys Ser Lys Glu  Glu Lys Glu Glu Phe  Leu Lys Ser 
    1010                 1015                 1020             


Lys Asn  Asp Lys Glu Lys Leu  Thr Phe Asn Ala Gln  Gln Trp Tyr 
    1025                 1030                 1035             


Gln Trp  Thr Asn Ala Asp Phe  Gly Arg Phe Arg Arg  Phe Leu Lys 
    1040                 1045                 1050             


Asp Lys  Arg Ile Pro Lys Leu  Ser Lys Tyr Phe Glu  Ser Lys Thr 
    1055                 1060                 1065             


Ile Pro  Phe Asp Leu Leu Glu  Tyr Gln Leu Phe Gln  Tyr Thr Ile 
    1070                 1075                 1080             


Tyr Arg  Glu Lys Met Phe Asp  Lys Val Phe Glu Leu  Glu Lys Arg 
    1085                 1090                 1095             


Met Ser  Glu Leu Phe Leu Asn  Asp Leu Val Lys Ile  Lys Leu Gln 
    1100                 1105                 1110             


Lys Asn  Asp Thr Phe Pro Glu  Val Ser Phe Gln Asp  Tyr Ile Lys 
    1115                 1120                 1125             


Val Leu  Glu Asn Lys His Tyr  Ser Phe Asp Lys Phe  Ile Leu Ser 
    1130                 1135                 1140             


Met Gly  Arg Lys Ser Val Ser  His Thr Gln Val Val  Phe Tyr Asp 
    1145                 1150                 1155             


Lys Ile  Pro Arg Ile Thr Gln  Gln Asn Met Asp Glu  Phe Glu Ala 
    1160                 1165                 1170             


Arg Lys  Thr Glu Lys Gly Tyr  Lys Glu Asn Leu Thr  Phe Asn Ile 
    1175                 1180                 1185             


Pro Lys  Gln Ile Phe Glu Ile  Phe Ser Lys Glu Val  Asp Asn Val 
    1190                 1195                 1200             


Leu His  His Phe Asn Ile Asn  Leu Thr Ser 
    1205                 1210             


<210>  2161
<211>  1230
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2161

Met Glu Asn Asn Pro Ser Asn Arg Phe Ser Lys Pro Ala Val Pro Pro 
1               5                   10                  15      


Lys Thr Arg Arg Ser Glu Gly Cys Glu Lys Pro Asp Ser His Ser Ala 
            20                  25                  30          


Glu Leu Lys Pro Val Phe Ala Ala Tyr Leu Asn Met Ala Gln Met Asn 
        35                  40                  45              


Leu Phe Asn Thr Leu Lys Ala Ile Glu Gly Lys Leu Gly Ile Val Thr 
    50                  55                  60                  


Gln Lys Gln Lys Ala Lys Glu Asp Cys Met Glu Glu Met Asn Ile Val 
65                  70                  75                  80  


Gly Phe Asp Lys Ile Lys Glu Val Glu Val Arg Ile Lys Ala Phe Lys 
                85                  90                  95      


Glu Leu Leu Lys Arg Ile Pro Val Leu Gln Ser Leu Ser Gly Tyr Gln 
            100                 105                 110         


Val Lys Gly Asp Val Lys Thr Val Ser Phe Glu Asn Val Ala Ala Leu 
        115                 120                 125             


Leu Leu Ala Ile Val Lys Ile Val His Tyr Tyr Arg Asn Glu Tyr Ser 
    130                 135                 140                 


His Thr His His Tyr Tyr Thr Asp Ala Glu Lys Ala Glu Glu Ala Asp 
145                 150                 155                 160 


Phe Glu Lys Arg Ile Met Gln Pro Leu Asp Leu Ala Phe Met Ser Ala 
                165                 170                 175     


Lys Arg Asn Met Ala Lys Val His Gly Tyr Gly Lys Lys Glu Leu Asp 
            180                 185                 190         


Phe Ile Asp Gly Asn Glu Arg Gln Glu Val Thr Gly Lys Gly Arg Asp 
        195                 200                 205             


Lys Lys Val Lys Tyr Tyr Thr Asp Tyr Tyr Phe Arg Leu Gly Asn Asp 
    210                 215                 220                 


Asp Phe Thr Arg Leu Ser Asp Val Gly Ile Ala Phe Ile Val Cys Lys 
225                 230                 235                 240 


Leu Leu Asn Lys Lys Tyr Ala Ile Gln Phe Leu Gln Gln Ser Lys Ile 
                245                 250                 255     


Met Thr Pro Arg Ser Gln Gly Gly Leu Ser Pro Phe Ser Gln Glu Glu 
            260                 265                 270         


Asn Glu Val Met Ala Asn Ile Phe Cys Ala Glu Arg Ile Arg Leu Pro 
        275                 280                 285             


Lys Gly Arg Met Glu Val Glu Ser Leu Asp Arg Lys Ala Ala Leu Gly 
    290                 295                 300                 


Leu Asp Met Leu Asn Glu Leu Gln Lys Cys Pro Lys Glu Leu Phe Asp 
305                 310                 315                 320 


Thr Phe Cys Gln Asp Asp Lys Glu Leu Phe Lys Val Val Gln Asp Glu 
                325                 330                 335     


Glu Glu Gln Gln Ser Asp Leu Glu Asp Gly Ala Leu Met Arg Arg Asn 
            340                 345                 350         


Asp Asp Arg Phe Pro Val Leu Ala Leu Arg Tyr Ile Asp Glu Gln Lys 
        355                 360                 365             


Val Leu Asn Gly Met Ala Phe Gln Val Ser Leu Gly Asn Tyr Arg Tyr 
    370                 375                 380                 


Gln Phe Tyr Asn Lys Thr Thr Ile Asp Pro Ser Asp Pro Asn Arg Val 
385                 390                 395                 400 


Arg Ile Leu Gln Lys Glu Ile Asn Gly Phe Gly Pro Met His Leu Val 
                405                 410                 415     


Glu Ser Lys Phe Lys Gly Lys Tyr Gly Lys Asp Gly Leu Asn Leu Ile 
            420                 425                 430         


Arg Glu Ser Gln Ser Glu Ala Pro Ala Asp Thr Ala Ala Thr Lys Pro 
        435                 440                 445             


Tyr Leu Thr Asp Lys Arg Ala Ser Tyr Val Ile His Asn Asn Arg Val 
    450                 455                 460                 


Cys Ile Met Leu Lys Glu Lys Gly Ser Pro Leu Asp Lys Asp Cys Cys 
465                 470                 475                 480 


Tyr Leu Pro Asp Leu Pro Val Pro Lys Glu Glu Asn Gly Thr Gln Lys 
                485                 490                 495     


Val Asn Arg Pro Gly Asp Glu Lys Glu Lys Asp Trp Pro His Thr Cys 
            500                 505                 510         


Trp Leu Ser Ile Tyr Asp Leu Pro Ala Leu Val Phe Leu His Leu Leu 
        515                 520                 525             


Gly Gly Asn Pro Gly Gln Val Ile Arg Asp Tyr Val Gly Lys Ile Arg 
    530                 535                 540                 


Arg Leu Leu Asn Asp Ile Val Glu Glu Glu Cys Val Pro Pro Cys Cys 
545                 550                 555                 560 


Asp Glu Pro Ser Pro Thr Asp Gly Ser Gln Arg Lys Lys Thr Ile Thr 
                565                 570                 575     


Lys Pro Lys Glu Val Val Asp Ile Trp Leu Lys Glu Gln Tyr Lys Leu 
            580                 585                 590         


Pro Leu Ser Ser Val Pro Glu Lys Ile Val Asp Tyr Leu Ala Gly Val 
        595                 600                 605             


Ser Gly Gly Ser Met Glu Glu Glu Arg Arg Lys Ala Glu Asp Gly Phe 
    610                 615                 620                 


Ser Lys Trp Ala Lys Ser Ala Val Glu Lys Glu Ile Gly Asp Thr Glu 
625                 630                 635                 640 


Leu Arg Gln Lys Arg Phe Gln Asn Asp Lys Lys Arg Val Gly Ser Lys 
                645                 650                 655     


Ala Asn Arg Ile Gly Lys Lys Ser Tyr Val Glu Ile Arg Pro Gly Arg 
            660                 665                 670         


Leu Ala Asp Phe Leu Ala Lys Asp Ile Met Lys Met Gln Pro Ala Asp 
        675                 680                 685             


Ala Glu Lys Asn His Cys Gly Lys Leu Thr Gly Gln Asn Tyr Gln Ile 
    690                 695                 700                 


Met Gln Ala Ala Ile Ala Thr Phe Lys Gly Asp Gly Arg Glu Cys Arg 
705                 710                 715                 720 


Leu Thr Gly Leu Gly Glu Leu Phe Val Lys Ala Gly Leu Val Gly Lys 
                725                 730                 735     


Asp Asn Arg Gln Lys His Pro Phe Leu Asp Lys Val Leu Thr Asn Glu 
            740                 745                 750         


Ile Thr Asp Thr Leu Asp Phe Tyr Glu Lys Tyr Leu Glu Glu Lys Lys 
        755                 760                 765             


Tyr Tyr Leu Glu Gln Leu Leu Cys Ser Glu Lys Tyr Ser Glu Ala Tyr 
    770                 775                 780                 


Phe Leu His Gly Gly Leu Asn Asp Tyr Lys Pro Lys Asp Arg Asp Tyr 
785                 790                 795                 800 


Ile Lys Leu Leu Ala Gly Arg Tyr Lys Asp Thr Phe Gln Leu Pro Asp 
                805                 810                 815     


Gly Leu Phe Ala Asp Ala Ile Ser Glu Cys Leu Lys Lys Glu Asp Asn 
            820                 825                 830         


Val Glu Ile Arg Asn Ala Ala Glu Gly Glu Asn Arg Asn Asn Ala Ala 
        835                 840                 845             


Tyr Leu Leu Arg Val Tyr Phe Thr Asn Lys Tyr Asp Asp Asp Ser Gln 
    850                 855                 860                 


Pro Phe Tyr Phe Gln Thr Asp Gly Arg Phe Lys Arg His Tyr Lys Val 
865                 870                 875                 880 


Phe Asp Thr Ile Glu Gly Lys Lys Asp Ala Thr Tyr Arg Thr Val Glu 
                885                 890                 895     


Glu Ile Arg Ala Met Leu Arg Lys Gly Ala Ala Asp Lys Ala Pro Val 
            900                 905                 910         


Arg Arg Ala Ile Ala Glu His Leu Asn Thr Met Gln Met Pro Gly Lys 
        915                 920                 925             


Pro Gln Arg Ile Asn Gly Lys Lys Lys Pro Thr Trp Arg Glu Ala Thr 
    930                 935                 940                 


Pro Asp Glu Lys Glu Ala Glu Ala Lys Lys Cys Gln Met Gln Leu Arg 
945                 950                 955                 960 


Tyr Cys Gln Gln Asn Glu Arg Ala Ile Arg Arg Tyr Lys Ala Glu Asp 
                965                 970                 975     


Met Leu Met Phe Met Met Ala Lys Arg Leu Leu Leu Glu Ser Asp Asn 
            980                 985                 990         


Val Leu Lys Lys Gly Asn Leu Asn  Gly Leu Glu Ala Phe  Lys Leu Arg 
        995                 1000                 1005             


Asp Ile  Lys Pro Ile Gly Cys  Lys Asn Gly Pro Gln  Asp Asn Ile 
    1010                 1015                 1020             


Leu Asn  Gln Gln Ile Asp Phe  Ser Ala Ala Ile Asp  Leu Phe Val 
    1025                 1030                 1035             


Glu Glu  Val Val His Tyr Thr  Asp Lys Lys Gly Glu  Glu Gly Thr 
    1040                 1045                 1050             


Arg Phe  Lys Thr Val Asn Lys  Gly Lys Lys Val Ile  Arg Gln Ser 
    1055                 1060                 1065             


Gly Leu  Lys Ile Lys Asn Ile  Gly Asp Phe Tyr Arg  Phe Ile Phe 
    1070                 1075                 1080             


Asp Ser  Arg Leu Gly Ser Leu  Leu Ser Gln Ile Glu  Gly Asp Thr 
    1085                 1090                 1095             


Phe Glu  Arg Glu Met Val Glu  Lys Glu Leu Asp Thr  Tyr Asp Asn 
    1100                 1105                 1110             


Arg Arg  Lys Asp Gly Phe Lys  Thr Ala His Glu Ile  Glu Arg Val 
    1115                 1120                 1125             


Ile Ile  Gly Lys Asn Lys Glu  Gln Ile Glu Thr Arg  Phe Lys Asn 
    1130                 1135                 1140             


Glu Ile  Ala Ala Gly Leu Glu  Ser Glu Lys Ile Val  Tyr Asn Lys 
    1145                 1150                 1155             


Phe Gly  Glu Leu Leu Lys Tyr  Cys Glu Leu Thr Ser  Asp Ile Gln 
    1160                 1165                 1170             


Ala Lys  Ile Val Asp Ile Arg  Asn Met Leu Ala His  Asn Lys Tyr 
    1175                 1180                 1185             


Met Asp  Asn Ile Glu Arg Val  Val Asp Lys Asp Asp  Met Thr Leu 
    1190                 1195                 1200             


Pro Gln  Val Leu Glu Lys Ile  Ile Glu Trp Leu Gln  Asp Asn Ser 
    1205                 1210                 1215             


Lys Lys  Ile Thr His Thr Asp  Glu Ser Thr Asn Thr  
    1220                 1225                 1230 


<210>  2162
<211>  1312
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2162

Met Ala Asn Asn Gln Phe Arg Leu Val Pro Val Asp Tyr Ser Arg Pro 
1               5                   10                  15      


Tyr Asp Gln Gln Pro Glu Cys Lys Arg His Val Ile Gly Ala Tyr Ala 
            20                  25                  30          


Asn Leu Ala Arg His Asn Met Thr Val Thr Ile Asn Ala Ile Met Gln 
        35                  40                  45              


Ala Ile Gly Leu Glu Leu Phe Asn Glu Asn Asn Ile Asp Glu Ala Phe 
    50                  55                  60                  


Asn Ser Ser His Arg Lys Ile Leu Ser Gln Leu Asp Asn Ile Gln Lys 
65                  70                  75                  80  


Val Asn Leu Gln Lys Arg Ile Tyr Arg His Phe Pro Phe Phe Lys Arg 
                85                  90                  95      


Met Lys Leu Glu Asp Glu Ser Lys Lys Ser Val Gln Leu Asn Lys Leu 
            100                 105                 110         


Leu Glu Ile Met Ser Asp Phe Thr Ser Cys Met Ser Met Ile Arg Asn 
        115                 120                 125             


Tyr Tyr Thr His Tyr His Pro Tyr Asn Ser Pro Ala Glu Leu Ala Asn 
    130                 135                 140                 


Gln Leu Glu Leu Lys Lys Glu Met Gly Lys Arg Leu Gln Tyr Leu Phe 
145                 150                 155                 160 


Glu Asn Thr Ser Gln Met Phe Lys Ser Tyr Glu Asn Leu Asp His Glu 
                165                 170                 175     


Ser Asn Glu Val Phe Ala Ala Leu Arg Ile Pro Glu Asp Tyr Ile Glu 
            180                 185                 190         


Glu Phe Met Pro Gly Asp Lys Asp Tyr Gln Lys Leu Glu Thr Leu Leu 
        195                 200                 205             


Lys Asp Pro Lys Val Ser Arg Phe Lys Lys Gln Gly Leu Lys Leu Asp 
    210                 215                 220                 


Met Lys Thr Leu Lys Ile Thr Lys Lys Ala Val Arg Tyr Ile Arg Asn 
225                 230                 235                 240 


Pro Glu Tyr Gln Ala Tyr Met Met Asp Lys Glu Lys Gly Met Ser Asp 
                245                 250                 255     


Ile Ala Val Ile Tyr Phe Leu Cys Leu Phe Leu Glu Lys Lys Val Ser 
            260                 265                 270         


Phe Glu Leu Met Glu Glu Val Gly Leu Thr Glu Gln Ile Lys Phe Asn 
        275                 280                 285             


Gly Glu Asn Ala Asp Gln Gln Leu Leu Phe Val Lys Glu Ile Leu Cys 
    290                 295                 300                 


Met Asn Arg Ile Arg Met Thr Lys Thr Lys Leu Asp Ser Glu Met Thr 
305                 310                 315                 320 


Asp Thr Ala Leu Ala Leu Asp Met Ile Asn Glu Leu Arg Lys Cys Pro 
                325                 330                 335     


Lys Pro Leu Tyr Glu Val Phe Cys Lys Glu Ala Arg Asp Glu Phe Lys 
            340                 345                 350         


Asp Asp Ser Thr Val Gln Trp Glu Lys Glu His Arg Thr Glu Thr Val 
        355                 360                 365             


Asn Thr Glu Glu Asn Thr Asp Ser Glu Asp Glu Arg Thr Ile Glu Lys 
    370                 375                 380                 


Asp Thr Pro Arg Ser Thr Phe Val Arg Trp Glu Asp Arg Phe Pro Gln 
385                 390                 395                 400 


Met Ala Leu Arg Tyr Ile Asp Tyr Gln Gly Leu Phe Asp Asp Ile Arg 
                405                 410                 415     


Phe Gln Leu Asn Leu Gly Lys Tyr Arg Phe Ala Phe Tyr Gln His Asp 
            420                 425                 430         


Lys Ala Tyr Ser Val Asp Asn Glu Glu Arg Leu Arg Ile Leu Gln Lys 
        435                 440                 445             


Glu Met His Gly Phe Gly Arg Ile Gln Glu Val Gln Ala Lys Lys Asn 
    450                 455                 460                 


Glu Lys Trp Ala Val Leu Tyr Asp Lys Lys Tyr Val Glu Glu Gly Leu 
465                 470                 475                 480 


Thr Lys Lys Lys Pro Asp Met Ala Gly Gln Ala Pro Tyr Val Thr Glu 
                485                 490                 495     


Gln Tyr Ala Gln Tyr Ala Ile Asp Glu Lys Ser His Ser Val Gly Leu 
            500                 505                 510         


Arg Trp Glu Gly Trp Lys Ala Thr Gly Asp Ser Lys Lys His Tyr Gly 
        515                 520                 525             


Asp Leu Asp Asn Gln Lys Met Phe Ile Pro Tyr Leu Pro Thr Lys Pro 
    530                 535                 540                 


Leu Pro Glu Gly Lys Gln Thr Asn Gln Ser Glu Pro Leu Leu Pro Pro 
545                 550                 555                 560 


Gln Ala Leu Leu Ser Leu Tyr Glu Leu Pro Gly Leu Leu Phe Phe Gln 
                565                 570                 575     


Tyr Leu Leu Val Lys Gln Glu Lys Asp Ile Phe Glu Ala Glu Asn Met 
            580                 585                 590         


Ile Lys Lys Tyr Tyr His Ser Leu Tyr Arg Phe Phe Gln Asp Val Ser 
        595                 600                 605             


Thr Gly Thr Leu Lys Pro Val Ala Asp Lys Asp Glu Lys Asp Thr Leu 
    610                 615                 620                 


Glu Lys Leu Ala Lys Val Leu Ser Ala Glu Pro Tyr Cys Leu Arg Leu 
625                 630                 635                 640 


Thr Asp Ile Pro Asp Lys Leu Lys Lys Tyr Leu Leu Gly Ile Ser Val 
                645                 650                 655     


Asp Asn Cys Gln Arg Met Glu Gln Ser Ala Ile Tyr Arg Leu Glu Glu 
            660                 665                 670         


Arg Lys Glu Arg Ile Gln Lys Ala Leu Asn Ser Phe Ile Asp Lys Lys 
        675                 680                 685             


Lys Lys Ile Gly Ser Lys Glu Asn Lys Phe Asp Lys Met Arg Ala Thr 
    690                 695                 700                 


Ile Lys Thr Gly Ser Leu Gly Gln Leu Leu Ala Arg Asp Ile Met Glu 
705                 710                 715                 720 


Trp Leu Thr Asp Glu Thr Lys Thr Arg Met Lys Leu Thr Gly Gln Asn 
                725                 730                 735     


Tyr Val Ala Met Gln Thr Ala Leu Thr Leu Leu Gly Gln Ser Phe Arg 
            740                 745                 750         


Gly Asp Arg Asp His Glu Val Asn Cys Thr Lys Leu Arg Glu Ile Phe 
        755                 760                 765             


Leu Lys Ser Asn Ile Leu Pro Glu Asn Asp Asp Asp Tyr Asp Ala Asp 
    770                 775                 780                 


Leu His His Pro Phe Leu Leu Asn Val Leu Asp Glu Glu Pro Ser Ser 
785                 790                 795                 800 


Val Glu Glu Phe Tyr Glu Ile Tyr Leu Glu Glu Glu Leu Asn His Ile 
                805                 810                 815     


Asp Tyr Met Ile Thr Phe Leu Lys Lys His Lys Ala Lys Gly Thr Ala 
            820                 825                 830         


Leu Tyr Ile Pro Phe Leu His Ala Asn Arg Ser Arg Trp Lys Asn Ala 
        835                 840                 845             


Asp Glu Asp Thr Met Lys Lys Leu Ala Thr Arg Tyr Met Glu Gln Pro 
    850                 855                 860                 


Leu Gln Leu Pro Asn Gly Met Phe Thr Glu Ser Ile Phe Lys Leu Leu 
865                 870                 875                 880 


Met Glu Ile Asp Asn Pro Asp Leu His Glu Glu Leu Val Lys Ala Glu 
                885                 890                 895     


Asn Pro Asp Ala Asp Lys Asn Leu Ala Asn Asn Val Ser Tyr Leu Met 
            900                 905                 910         


Ser Ile Tyr Phe Lys His Val Glu Arg Asp His Ser Gln Pro Phe Tyr 
        915                 920                 925             


Asn Thr Thr Ala Ile Glu Gly Glu Pro Ser Pro Tyr Arg His Val Tyr 
    930                 935                 940                 


Arg Ile Phe Lys Lys Leu Tyr Gly Gln Gln Ile Pro His Thr Asn Gln 
945                 950                 955                 960 


Thr Thr Thr Pro Ala Tyr Thr Val Glu Glu Ile Asn Gly Leu Arg Lys 
                965                 970                 975     


Gln Ala Leu Thr Asp Ile Ala Lys Tyr Val Glu Lys Asp Ile Ser Asn 
            980                 985                 990         


Trp Lys Asp Arg Gln Gln Phe Lys  Phe Glu Gln Lys Leu  Lys Lys Lys 
        995                 1000                 1005             


Leu Lys  Lys Glu Asn Asp Arg  Arg Tyr Lys Asn His  Glu Gln Gln 
    1010                 1015                 1020             


Leu Asn  Val Tyr Glu Glu Val  Asn Lys Val Val Gln  Gln Glu Ile 
    1025                 1030                 1035             


Asn Thr  Met Arg Thr Thr Thr  Thr Ala Lys Leu Ile  Arg Gln Leu 
    1040                 1045                 1050             


Lys Lys  Val Tyr Asp Asn Glu  Arg Thr Ile Arg Arg  Phe Lys Thr 
    1055                 1060                 1065             


Gln Asp  Met Leu Met Leu Ile  Met Ala Arg Glu Ile  Leu Lys Ala 
    1070                 1075                 1080             


Lys Ser  Gln Asn Lys Asp Phe  Thr Lys Asp Phe Cys  Leu Lys Tyr 
    1085                 1090                 1095             


Val Met  Thr Asp Ser Leu Leu  Asp Lys Pro Ile Asp  Phe Asp Trp 
    1100                 1105                 1110             


Ser Val  Asn Ile Glu Lys Lys  Lys Lys Asn Glu Glu  Gly Lys Ile 
    1115                 1120                 1125             


Glu Lys  Glu Ile Ile Arg Lys  Thr Ile Arg Gln Glu  Gly Met Lys 
    1130                 1135                 1140             


Met Lys  Asn Tyr Gly Gln Phe  Tyr Lys Phe Ala Ser  Asp His Gln 
    1145                 1150                 1155             


Arg Leu  Glu Ser Leu Leu Ser  Arg Leu Pro Asp Glu  Leu Phe Leu 
    1160                 1165                 1170             


Arg Ala  Glu Ile Glu Asn Glu  Leu Ser Tyr Tyr Asp  Thr Asn Arg 
    1175                 1180                 1185             


Ser Glu  Val Phe Arg Leu Val  Tyr Ile Ile Glu Ser  Glu Ala Tyr 
    1190                 1195                 1200             


Lys Leu  Lys Pro Glu Leu Ala  Asn Asp Ala Asn Thr  Asp Lys Glu 
    1205                 1210                 1215             


Trp Phe  Tyr Tyr Ala Asp Lys  Lys Gly Lys Lys His  Pro Lys Arg 
    1220                 1225                 1230             


Asn Asn  Phe Leu Ser Leu Leu  Glu Ile Leu Ala Ala  Gly Lys Asp 
    1235                 1240                 1245             


Gly Ile  Leu Asn Glu Asp Glu  Lys Arg Ser Leu Gln  Ser Thr Arg 
    1250                 1255                 1260             


Asn Ala  Phe Gly His Asn Thr  Tyr Asp Val Asp Leu  Pro Thr Val 
    1265                 1270                 1275             


Phe Glu  Gly Lys Glu Glu Lys  Met Lys Ile Pro Glu  Val Ala Asn 
    1280                 1285                 1290             


Gly Ile  Lys Asp Lys Ile Glu  Asn Gln Thr Glu Glu  Leu Lys Lys 
    1295                 1300                 1305             


Ser Leu  Gln Lys 
    1310         


<210>  2163
<211>  1040
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2163

Met Thr Thr Lys Asp Val Ile Glu Val Gln Thr Asp Glu Thr Leu Lys 
1               5                   10                  15      


His Val Phe Gly Ala Tyr Leu Asn Met Ala Arg Asn Asn Leu Arg Ile 
            20                  25                  30          


Val Leu Glu Tyr Val Asp Glu Lys Val Phe Arg Lys Arg Arg Met Asn 
        35                  40                  45              


Glu Asp Ala Leu His Glu Ser Asp Leu Ile Lys Ser Leu Leu Lys Asn 
    50                  55                  60                  


Glu Arg Pro Asp Glu Gln Gln Arg Ala Thr Gly Leu Leu Lys Gln Leu 
65                  70                  75                  80  


Leu Pro Phe Leu Thr Leu Leu Val Arg Asn Gln Ser Asn Ser Ser Ala 
                85                  90                  95      


Gln Asp Tyr Ala Ser Val Leu Val Ser Phe Ile Lys Ala Leu Asn Gly 
            100                 105                 110         


Ala Arg Asn Phe Tyr Cys His Ser Leu His Gln Pro Leu Thr Ile Glu 
        115                 120                 125             


Ser Arg Leu Val Asn Ser Leu Glu Tyr Leu Phe Asp Ala Ala Arg Arg 
    130                 135                 140                 


Lys Thr Lys Val Arg Phe Gly Leu Ser Leu Glu Asp Ile Glu His Leu 
145                 150                 155                 160 


Val Arg Lys Pro Ala Val Lys Lys Gly Lys Lys Thr Glu Ile Val Cys 
                165                 170                 175     


Lys Gln Asp Phe Arg Tyr Gln Phe Ile Ser Asn Asn Asn Lys Phe Thr 
            180                 185                 190         


Gln Glu Gly Leu Ala Tyr Phe Ile Cys Leu Phe Leu Glu Arg Lys Tyr 
        195                 200                 205             


Ser Glu Leu Phe Leu Lys Lys Ile Pro Asn Phe Lys Asp Ser Arg Tyr 
    210                 215                 220                 


Lys Lys Tyr Gln Ala Thr Ile Asp Thr Tyr Ser Ile Leu Ser Leu Lys 
225                 230                 235                 240 


Leu Pro Lys Pro Arg Ile Gln Ser Ser Asp Asn Lys Glu Ala Leu Leu 
                245                 250                 255     


Leu Asp Ile Leu Glu Glu Leu Lys Arg Cys Pro Gly Glu Leu Phe Asp 
            260                 265                 270         


Arg Leu Leu Pro Glu Asp Gln Asn Arg Phe Arg Ile Leu Gly Asp Asp 
        275                 280                 285             


Glu Asn Gly Ser Asn Thr Pro Val Leu Ile Lys Arg Phe Gly Asp Arg 
    290                 295                 300                 


Phe Pro Asn Leu Val Phe Arg Tyr Phe Glu Leu Thr Gly Arg Leu Pro 
305                 310                 315                 320 


Trp Ile Gln Phe Tyr Ile Asp Leu Gly Thr Tyr Asn Tyr Glu Ile Tyr 
                325                 330                 335     


Lys Lys Glu Val Gly Gly Glu Gln Arg Leu Arg Arg Leu Gln His His 
            340                 345                 350         


Leu Lys Gly Phe Gly Tyr Ile Glu Asp Phe Asp Tyr Glu Lys Leu Pro 
        355                 360                 365             


Glu Ser Trp Arg Ser Leu Ile Arg Lys Ser His Glu Leu Thr Ala Asp 
    370                 375                 380                 


Tyr Glu Glu Ser His Ile Ile Phe Thr His Pro His Tyr His Phe Val 
385                 390                 395                 400 


Asn Ser Ser Ile Gly Ile Tyr Val Asp Pro Thr Lys Gln Asp Pro Ile 
                405                 410                 415     


Leu Pro Asp Leu Asn Thr Arg Lys Asn Thr Gln Pro His Ala Trp Leu 
            420                 425                 430         


Ser Lys Tyr Asp Leu Pro Ala Met Val Phe Leu His Leu Leu Thr Lys 
        435                 440                 445             


Lys Gly His Ile Ser Phe Gln Pro Ser Lys Val Ile Asn Gln Tyr Ile 
    450                 455                 460                 


Glu Thr Tyr Arg Lys Phe Phe Ser Asp Leu Ser Gly Ser Thr Thr Ile 
465                 470                 475                 480 


Ser Pro Glu Trp Leu Arg Glu Asn Leu Glu Asn Phe Asn Leu Thr Pro 
                485                 490                 495     


Ser Gln Ile Pro Lys Ala Ile Ala Cys His Leu Ser Asn Ala Ser Gln 
            500                 505                 510         


Asn Leu Met Leu Asp Lys Gly Lys Arg Lys Leu Ala Arg Phe Ile Gln 
        515                 520                 525             


Asp Thr Asp Ser Arg Leu Arg Asn Leu Glu Lys Leu Ile Glu Arg Ser 
    530                 535                 540                 


Lys Glu Arg Pro Gly Ser Lys Tyr His Arg Leu Val Lys Thr Gly Arg 
545                 550                 555                 560 


Leu Ala Asp Phe Leu Ala Arg Asp Met Leu Leu Leu Gln Pro Pro Ile 
                565                 570                 575     


Asp Glu Lys Lys Gly Lys Ala Thr Ser Thr Leu Phe Gln Val Leu Gln 
            580                 585                 590         


Ala Arg Leu Ala Phe Tyr Gly Arg Asp Lys Glu Leu Leu Ser Ser Leu 
        595                 600                 605             


Tyr Lys Glu Cys Asn Leu Val Asp Ser Glu Asn Pro His Pro Phe Leu 
    610                 615                 620                 


Glu Lys Val Pro Ser Ala Ser Asn Ile Val Asp Phe Tyr Arg Asn Tyr 
625                 630                 635                 640 


Leu Arg His Arg Lys Gln Tyr Met Glu Lys Leu Leu Ser Glu Cys Thr 
                645                 650                 655     


His Asp Thr Leu Lys Glu Arg Gln Tyr His Phe Leu His Phe Gly Glu 
            660                 665                 670         


Arg Asp Arg Lys Asp Asp Ser Lys Tyr Cys Ser Asn Leu Ala Arg Lys 
        675                 680                 685             


Leu Ser Lys Met Pro Phe Asn Leu Pro Arg Gly Leu Phe Ile Arg Pro 
    690                 695                 700                 


Ile Phe Asn His Leu Thr Ser Arg Gly Pro Glu Ala Val Lys Asn Lys 
705                 710                 715                 720 


Leu Val Ser Asn Glu Arg Asn Asn Thr Val Phe Met Leu Gln Thr Tyr 
                725                 730                 735     


Met Asn Arg Ala Tyr Asn Asp Ser Thr Gln Glu Tyr Tyr Asn Trp Pro 
            740                 745                 750         


Arg Asn Tyr Pro Ile Phe Ser Tyr Ile Phe Gly Ser Gly Glu Lys Lys 
        755                 760                 765             


Ser Asn Asn Asn Ile Asn Lys Ile Tyr Phe Thr Pro Ala Gln Leu Glu 
    770                 775                 780                 


Thr Lys Ala Ser Glu Ile Lys Ala Tyr Ile Asn Ser Ala Ala His Ile 
785                 790                 795                 800 


Gln Glu Glu Asp Lys Asn Lys Leu Ile Arg Glu Tyr Lys Asn Phe Ile 
                805                 810                 815     


Tyr Ser Glu Lys Met Ile Arg His Thr Lys Ala Cys Asp Ile Val Leu 
            820                 825                 830         


Phe Leu Met Ala Lys Asp Leu Leu Met Gln Leu Asp Gln Thr Ile Met 
        835                 840                 845             


Lys Pro Glu Ser Leu Asn Asn Phe Lys Leu Asn Glu Ile Gly Pro Gly 
    850                 855                 860                 


Asp Thr Gly Glu Val Met Ser Leu Lys Met Thr Phe Arg Phe Lys Ile 
865                 870                 875                 880 


Gln Thr Lys Thr Val Val Ala Arg Asp Leu Lys Leu Lys Asn Tyr Gly 
                885                 890                 895     


Ser Phe Lys Arg Leu Leu Lys Asp Asn Arg Ile Glu Ser Leu Leu Glu 
            900                 905                 910         


Trp Tyr Asp Glu Asp Glu Ile Glu Ile Gly Thr Ile Tyr Arg Glu Leu 
        915                 920                 925             


Glu Ala Tyr Asp Arg Val Arg Leu Glu Val Gln Lys Leu Ile Leu Glu 
    930                 935                 940                 


Phe Glu Ser Lys Cys Ile Ala Arg Tyr Gly Leu Gly Leu Arg Ala Gly 
945                 950                 955                 960 


Thr Asp Asp His His Leu Lys His Ser Glu Ile Leu Lys Glu Phe Thr 
                965                 970                 975     


Asn Gln Thr Gly Asn Ser Ile Ala Ala Glu Lys Met Asn Ile Ile Arg 
            980                 985                 990         


Asn Ser Phe Met His Asn Arg Phe  Pro Gln Lys Glu Lys  Phe Glu Asn 
        995                 1000                 1005             


Asp Ile  Leu Ser Asp Glu Pro  Ile Ala Val Gln Phe  Arg Glu Leu 
    1010                 1015                 1020             


Tyr Glu  Lys Leu Met Ser Gln  Val Ala Gln Ala Ala  Thr Lys Thr 
    1025                 1030                 1035             


Ser Val  
    1040 


<210>  2164
<211>  1126
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2164

Met Tyr Thr Asn Asp Asn Asn Gly Arg Asp Lys Ser Val Gly His Pro 
1               5                   10                  15      


Leu Asp Arg Phe Met Gly Gly Arg Asn Lys Thr Val Asp Leu Ala His 
            20                  25                  30          


Phe Tyr Asn Leu Ala Leu Asp Ala Val Asp Lys Ile Lys Ile Thr His 
        35                  40                  45              


Pro Leu Ser Asn Val Gly Phe Trp Ser Glu Tyr Phe Trp Arg Ser His 
    50                  55                  60                  


Leu Asp Arg Lys Asn Asn Lys Ala Tyr Val Pro Thr Asp Ile Glu Ala 
65                  70                  75                  80  


Lys Leu Val Gln Glu Thr Tyr Ala Lys Leu Lys Gln Ile Arg Asn Phe 
                85                  90                  95      


Gln Ser His Ile Trp His Asp Asp Cys Val Leu Ala Phe Ser Thr Glu 
            100                 105                 110         


Leu Ala Ser Trp Ile Lys Asn Lys Tyr Glu Arg Ala Lys Ala Tyr Leu 
        115                 120                 125             


Phe Glu Asn Asn Gln Gln Ala Met Leu Asp Phe Glu Ala Leu Asp Asn 
    130                 135                 140                 


Gln His Pro Arg Pro Leu Phe Lys Gln Val His Ser Thr Phe Tyr Ile 
145                 150                 155                 160 


Thr Val Glu Gly Arg Ile Phe Phe Leu Ser Phe Phe Leu Ser Arg Glu 
                165                 170                 175     


Gln Met Asn Ser Leu Leu Gln Gln Arg Lys Gly His Lys Arg Thr Asp 
            180                 185                 190         


Met Pro Leu Tyr Lys Met Lys Arg Glu Leu Tyr Thr Phe Tyr Cys His 
        195                 200                 205             


Arg Asp Gly Ala Ala Ile Ala Arg Met Asn Gln Ala Asn Asp Glu Trp 
    210                 215                 220                 


Asn Phe Leu Arg Pro Glu Gln Gln Lys Asp Ile Lys Leu Ala Arg Gln 
225                 230                 235                 240 


Ala Phe Arg Leu Leu Ser Tyr Leu Gln Asp Tyr Pro Ser Cys Trp Lys 
                245                 250                 255     


Thr Leu Leu Pro Glu His Pro Ser Glu Leu Leu Val Tyr Cys Lys Glu 
            260                 265                 270         


Arg Gly Ile Leu Ser Glu Phe His Ile Gln Leu Glu Arg Asp Gly Phe 
        275                 280                 285             


His Leu Glu His Glu Arg Phe Thr Gly Gln Thr Trp Leu Met Lys Thr 
    290                 295                 300                 


Ser His Phe Arg Glu Leu Leu Thr Leu Ile Met Leu Phe Glu Phe Thr 
305                 310                 315                 320 


Gly Arg Thr Arg His Pro Lys Asp Leu Leu Leu Leu Arg Met Glu Lys 
                325                 330                 335     


Leu Leu Glu His Arg Thr Lys Met Ile Thr Leu Met Gln Lys Ser Val 
            340                 345                 350         


Phe Lys Leu Thr Glu Asp Glu Ile Asp Phe Leu Gln Ile Pro Glu His 
        355                 360                 365             


Gln Leu Leu Arg Thr Gln Arg Leu Thr Thr Gln Asn Leu Ile Ala Tyr 
    370                 375                 380                 


Phe Glu Gln Phe Asp Pro Gln Lys Glu Ser Thr Gly Lys Leu Gly Arg 
385                 390                 395                 400 


Lys Leu Ala Gly Phe Leu Glu Ile Glu Pro Ile Gln Leu Tyr Pro Gln 
                405                 410                 415     


Asp Phe Asn Glu Thr Glu Thr Arg Lys Phe Arg Asn Asp Asn Gln Phe 
            420                 425                 430         


Met Leu Phe Ala Ala Gln Tyr Leu Met Asp Phe Gly Pro Glu Glu Trp 
        435                 440                 445             


Tyr Trp Cys Met Glu Arg Phe Glu Asn Gly Val Pro Gly Glu Gly Glu 
    450                 455                 460                 


Lys Val Thr Leu Asn Lys Ile Lys Glu Phe His Gln Pro Ala Val Ala 
465                 470                 475                 480 


Lys Ala Leu Ala Asp Phe Arg Ile Cys Ile Glu Glu Asp His Val Ile 
                485                 490                 495     


Leu Gly Ile Pro Lys Ser Pro Asp Gly Val Leu Val Glu Gly Val Pro 
            500                 505                 510         


Asn Tyr Lys Ser Phe Tyr Gln Ile Ala Ile Gly Pro Lys Ala Met Arg 
        515                 520                 525             


Tyr Leu Met Ala Arg Met Leu Val Asp Ser Lys Ala Ile Thr Pro Leu 
    530                 535                 540                 


Lys Ala Leu Pro Val Arg Leu Lys Asn Asp Leu Asp Leu Leu Arg Lys 
545                 550                 555                 560 


Lys Gly Gly Trp Ala Asp Gly Lys Gly Phe Lys Leu Leu Glu Pro Val 
                565                 570                 575     


Phe Leu Pro Pro Tyr Leu Lys Asn Pro Thr Gly Asp Ile Ser Lys Leu 
            580                 585                 590         


Phe Asn Ser Ala Leu Asn Arg Leu Thr His Met Arg Gln Val Trp Gln 
        595                 600                 605             


Glu Val Val Glu His Pro Asp Arg Phe Thr Arg His Glu Lys Asn Arg 
    610                 615                 620                 


Leu Val Met Leu Leu Tyr Arg Gln Phe Asp Trp Val Pro Glu Lys Gly 
625                 630                 635                 640 


Asn Thr Val Lys Phe Leu Arg Arg His Glu Tyr Gln Gln Leu Ser Val 
                645                 650                 655     


Cys His Tyr Ser Leu His Leu Lys Lys Lys Lys Val Gly Tyr Ser Arg 
            660                 665                 670         


Asn Lys Gly Gly Gly Ser Ser Pro Asn Lys Phe Glu Lys Leu Phe Arg 
        675                 680                 685             


Asp Val Phe Gln Leu Asp Thr Arg Lys Pro Pro Ile Pro Arg Glu Ile 
    690                 695                 700                 


Lys Ser Leu Leu Gln Gln Ala Asn Asp Leu Asp Asp Leu Val Gly Ile 
705                 710                 715                 720 


Val Gly Gln His Gln Ile Pro Arg Leu Glu Ala Glu Leu Asn Asn Ile 
                725                 730                 735     


Ala Ser Leu Pro Asn Leu Gln Arg Lys Lys Ala Leu Ser Gln Phe Cys 
            740                 745                 750         


Arg Lys Ile Gly Leu Ser Ile Pro Val Asn Cys Leu Val Thr Ser Glu 
        755                 760                 765             


Gln Gln Met Leu Arg Lys Lys His Ser Glu Thr Leu Glu Phe Gln Val 
    770                 775                 780                 


Ile Pro Leu His Pro Met Leu Val Val Lys Ala Leu Phe Thr Asp Glu 
785                 790                 795                 800 


Tyr Gln Gln Ser Thr Asp Glu Asn Arg Gln Gln Gln Ile Gly Gly Arg 
                805                 810                 815     


Lys Ala Leu Ser Ile Phe Lys Asn Ile Arg Glu Asp Gln Leu Arg Cys 
            820                 825                 830         


Gly Leu Leu Arg Asn Asp Tyr Tyr Arg His Glu Ile Ala Gln Glu Leu 
        835                 840                 845             


Phe Cys Glu Thr Asp Ala Val Lys Val Arg Glu Asn Ala Val Gly Leu 
    850                 855                 860                 


Leu Asp Lys Thr Lys Thr Glu Asp Val Ile Ile Ala Trp Met Ala Glu 
865                 870                 875                 880 


Gln Tyr Leu Ser Lys Asn Pro Phe Thr Glu Val Leu Ser Asn Arg Ile 
                885                 890                 895     


Lys Asp Val Ile Asn Gln Asn Arg Ser Tyr Ala Pro Glu Leu Tyr His 
            900                 905                 910         


Glu Pro Ile Thr Leu Glu Ile Cys Asp Asn Lys Gly Lys Gly Ile Gly 
        915                 920                 925             


Leu Tyr Met Gln Val Arg Leu His Gln Leu Asp Asp Leu Ile Tyr Asn 
    930                 935                 940                 


Ser His Arg Tyr Met Phe Pro Lys Ala Ala His Leu Tyr Arg Arg Arg 
945                 950                 955                 960 


Leu Phe Glu Glu Asn Thr Ile Trp Glu Ser Glu Leu Gln Arg Leu Arg 
                965                 970                 975     


Glu Asp Arg Leu Lys Gly Ala Pro Leu Pro Asp Gly Ser Leu Glu Ser 
            980                 985                 990         


Pro Ile Pro Ile Glu Leu Leu Ile  Asp Glu Ile Arg Leu  Val Arg Arg 
        995                 1000                 1005             


Thr Ala  Leu Lys Leu Gly Asn  Ala Leu Phe Asp Phe  Glu Arg Ser 
    1010                 1015                 1020             


Val Ile  Glu Lys Leu Gly Thr  Ala His Leu Asp Lys  Asp Ala Phe 
    1025                 1030                 1035             


Gln Thr  Trp Leu Ile Asn Arg  Asn Pro Leu Glu Lys  Ala Glu Asp 
    1040                 1045                 1050             


Val His  His Phe Lys Phe Asp  Asn Ile Leu Val His  Ala Val Glu 
    1055                 1060                 1065             


Leu Gly  Leu Ile Asp Ser Asp  Leu Phe Asn Arg Leu  Lys Lys Val 
    1070                 1075                 1080             


Arg Asp  Lys Val Leu His Gly  Asn Ile Pro Glu Glu  Ser Phe Ser 
    1085                 1090                 1095             


Trp Met  Thr Arg Glu Gly Glu  Gln Leu Arg Ser Val  Leu Asn Ile 
    1100                 1105                 1110             


Leu Glu  Asp Leu His Ala Gly  Lys Asp Glu Ala Lys  Tyr 
    1115                 1120                 1125     


<210>  2165
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2165

Met Glu Asp Asp Lys Lys Thr Thr Asp Ser Ile Arg Tyr Glu Leu Lys 
1               5                   10                  15      


Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val 
            20                  25                  30          


Tyr Ile Thr Val Asn His Ile Asn Lys Ile Leu Glu Glu Asp Glu Ile 
        35                  40                  45              


Asn Arg Asp Gly Tyr Glu Asn Thr Leu Glu Asn Thr Trp Asn Glu Ile 
    50                  55                  60                  


Lys Asp Ile Asn Lys Lys Asp Arg Leu Ser Lys Leu Ile Ile Lys His 
65                  70                  75                  80  


Phe Pro Phe Leu Glu Ala Thr Thr Tyr Arg Gln Asn Pro Thr Asp Thr 
                85                  90                  95      


Thr Lys Gln Lys Glu Glu Lys Gln Ala Glu Ala Gln Ser Leu Glu Ser 
            100                 105                 110         


Leu Lys Lys Ser Phe Phe Val Phe Ile Tyr Lys Leu Arg Asp Leu Arg 
        115                 120                 125             


Asn His Tyr Ser His Tyr Lys His Ser Lys Ser Leu Glu Arg Pro Lys 
    130                 135                 140                 


Phe Glu Glu Asp Leu Gln Asn Lys Met Tyr Asn Ile Phe Asp Val Ser 
145                 150                 155                 160 


Ile Gln Phe Val Lys Glu Asp Tyr Lys His Asn Thr Asp Ile Asn Pro 
                165                 170                 175     


Lys Lys Asp Phe Lys His Leu Asp Arg Lys Arg Lys Gly Lys Phe His 
            180                 185                 190         


Tyr Ser Phe Ala Asp Asn Glu Gly Asn Ile Thr Glu Ser Gly Leu Leu 
        195                 200                 205             


Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Val Gln 
    210                 215                 220                 


Lys Lys Leu Glu Gly Phe Lys Cys Ser Asn Lys Ser Tyr Gln Lys Met 
225                 230                 235                 240 


Thr Asn Glu Val Phe Cys Arg Ser Arg Met Leu Leu Pro Lys Leu Arg 
                245                 250                 255     


Leu Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu Asn 
            260                 265                 270         


Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Gln Gly Val 
        275                 280                 285             


Asn Arg Lys Lys Phe Tyr Val Ser Phe Asp Pro Ala Asp Glu Asp Tyr 
    290                 295                 300                 


Asp Ala Glu Gln Glu Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp 
305                 310                 315                 320 


Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Tyr Asn Glu Val Phe 
                325                 330                 335     


Ala Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile 
            340                 345                 350         


Tyr Lys Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg His Leu Thr His 
        355                 360                 365             


Lys Leu Tyr Gly Phe Glu Arg Ile Gln Glu Phe Asp Lys Gln Asn Arg 
    370                 375                 380                 


Pro Asp Glu Trp Lys Ala Ile Val Lys Asp Ser Asp Thr Phe Lys Lys 
385                 390                 395                 400 


Lys Glu Glu Lys Glu Glu Glu Lys Pro Tyr Ile Ser Glu Thr Thr Pro 
                405                 410                 415     


His Tyr His Leu Glu Asn Lys Lys Ile Gly Ile Ala Phe Lys Asn His 
            420                 425                 430         


Asn Ile Trp Pro Ser Thr Gln Thr Glu Leu Thr Asn Asn Lys Arg Lys 
        435                 440                 445             


Lys Tyr Asn Leu Gly Thr Ser Ile Lys Ala Glu Ala Phe Leu Ser Val 
    450                 455                 460                 


His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Lys Thr Glu 
465                 470                 475                 480 


Asn Thr Lys Asn Asp Asn Lys Val Gly Gly Lys Lys Glu Thr Lys Lys 
                485                 490                 495     


Gln Gly Lys His Lys Ile Glu Ala Ile Ile Glu Ser Lys Ile Lys Asp 
            500                 505                 510         


Ile Tyr Ala Leu Tyr Asp Ala Phe Ala Asn Gly Glu Ile Asn Ser Glu 
        515                 520                 525             


Asp Glu Leu Lys Glu Tyr Leu Lys Gly Lys Asp Ile Lys Ile Val His 
    530                 535                 540                 


Leu Pro Lys Gln Met Ile Ala Ile Leu Lys Asn Glu His Lys Asp Met 
545                 550                 555                 560 


Ala Glu Lys Ala Glu Ala Lys Gln Glu Lys Met Lys Leu Ala Thr Glu 
                565                 570                 575     


Asn Arg Leu Lys Thr Leu Asp Lys Gln Leu Lys Gly Lys Ile Gln Asn 
            580                 585                 590         


Gly Lys Arg Tyr Asn Ser Ala Pro Lys Ser Gly Glu Ile Ala Ser Trp 
        595                 600                 605             


Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln Lys Asp Asn Glu 
    610                 615                 620                 


Gly Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln Leu 
625                 630                 635                 640 


Leu Gln Arg Thr Leu Ala Phe Phe Gly Ser Glu His Glu Arg Phe Ala 
                645                 650                 655     


Pro Tyr Phe Lys Gln Thr Lys Leu Ile Glu Ser Ser Asn Pro His Pro 
            660                 665                 670         


Phe Leu Lys Asp Thr Glu Trp Glu Lys Cys Asn Asn Ile Leu Ser Phe 
        675                 680                 685             


Tyr Arg Ser Tyr Leu Glu Ala Lys Lys Asn Phe Leu Glu Ser Leu Lys 
    690                 695                 700                 


Pro Glu Asp Trp Glu Lys Asn Gln Tyr Phe Leu Met Leu Lys Glu Pro 
705                 710                 715                 720 


Lys Thr Asn Arg Lys Thr Leu Val Gln Gly Trp Lys Asn Gly Phe Asn 
                725                 730                 735     


Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg Lys Trp Phe Met Glu 
            740                 745                 750         


His Trp Lys Ser Ile Lys Val Asp Asp Ser Lys Arg Val Gly Leu Val 
        755                 760                 765             


Ala Lys Val Ile Pro Leu Phe Phe Ser Glu Lys Tyr Lys Asp Ser Val 
    770                 775                 780                 


Gln Pro Phe Tyr Asn Tyr Pro Phe Asn Val Gly Asp Val Asn Lys Pro 
785                 790                 795                 800 


Lys Glu Glu Asp Phe Leu His Arg Lys Asp Arg Ile Glu Leu Trp Asp 
                805                 810                 815     


Lys Lys Lys Val Gly Phe Lys Gly Tyr Lys Ala Lys Glu Lys Pro Lys 
            820                 825                 830         


Glu Met Thr Asp Glu Glu Lys Lys Glu His Arg Ser Tyr Leu Glu Phe 
        835                 840                 845             


Gln Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Val Arg Asn Gln 
    850                 855                 860                 


Asp Ile Val Thr Trp Leu Leu Cys Thr Glu Leu Ile Asp Lys Leu Lys 
865                 870                 875                 880 


Val Glu Gly Leu Asn Val Glu Glu Leu Gln Lys Leu Arg Leu Lys Asp 
                885                 890                 895     


Ile Asn Thr Asp Thr Ala Lys Lys Glu Lys Asn Asn Ile Leu Asn Arg 
            900                 905                 910         


Val Met Pro Met Glu Leu Pro Val Thr Val Tyr Glu Val Asn Lys Ala 
        915                 920                 925             


Ser Asn Ile Ile Lys Asn Lys Pro Leu His Thr Ile Tyr Ile Lys Glu 
    930                 935                 940                 


Ala Lys Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys 
945                 950                 955                 960 


Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Val Asp Thr Ser Ser Lys 
                965                 970                 975     


Ala Glu Ser Glu Ser Asn Thr Ile Ser Lys Ser Arg Val Glu Tyr Glu 
            980                 985                 990         


Leu Gly Glu Tyr Gln Lys Ala Arg  Ile Glu Ile Ile Lys  Asp Met Leu 
        995                 1000                 1005             


Ala Leu  Glu Lys Thr Leu Ile  Asp Lys Tyr Asn Ser  Leu Asp Thr 
    1010                 1015                 1020             


Asp Asn  Phe Asn Lys Met Leu  Thr Asp Trp Leu Glu  Leu Lys Asn 
    1025                 1030                 1035             


Lys Ala  Asn Lys Ala Ser Leu  Glu Lys Thr Asp Lys  Thr Ser Phe 
    1040                 1045                 1050             


Gln Asn  Asp Val Asp Leu Leu  Ile Ala Val Arg Asn  Ala Phe Ser 
    1055                 1060                 1065             


His Asn  Gln Tyr Pro Met Arg  Asn Arg Ile Ala Phe  Ala Asn Ile 
    1070                 1075                 1080             


Asn Pro  Phe Ser Leu Ser Ser  Ala Asp Thr Ser Glu  Glu Lys Gly 
    1085                 1090                 1095             


Leu Gly  Ile Ala Asn Gln Leu  Lys Glu Lys Thr His  Lys Thr Ile 
    1100                 1105                 1110             


Glu Lys  Ile Ile Lys Ile Glu  Lys Pro Ile Glu Thr  Lys Glu 
    1115                 1120                 1125         


<210>  2166
<211>  1175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2166

Met Thr Glu Gln Asn Glu Lys Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Phe Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Ala His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Cys Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Glu Lys Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Ala Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Phe Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Asp Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Gly Glu Ile Asp Thr Leu Asp 
    530                 535                 540                 


Arg Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Met Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Gly Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Tyr Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Trp Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Asp Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Asp Leu Glu Ala Trp Ser His Ser Ala Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Ala Gly Ile Glu Tyr Ala Ser Pro Gly Asn 
    850                 855                 860                 


Lys Lys Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Glu Thr 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Lys Ala Asp Lys Ile Asn Ile Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Ala Gln Glu His Pro Tyr Leu Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asp Ile Arg Thr 
945                 950                 955                 960 


Glu Val Gln Glu Gln Gly Ser Leu Asn Val Leu Asn Arg Val Lys Pro 
                965                 970                 975     


Met Arg Leu Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val 
            980                 985                 990         


His Lys Glu Gln Ala Pro Leu Ala  Thr Val Tyr Ile Glu  Glu Arg Asp 
        995                 1000                 1005             


Thr Lys  Leu Leu Lys Gln Gly  Asn Phe Lys Ser Phe  Val Lys Asp 
    1010                 1015                 1020             


Arg Arg  Leu Asn Gly Leu Phe  Ser Phe Val Asp Thr  Gly Gly Leu 
    1025                 1030                 1035             


Ala Met  Glu Gln Tyr Pro Ile  Ser Lys Leu Arg Val  Glu Tyr Glu 
    1040                 1045                 1050             


Leu Ala  Lys Tyr Gln Thr Ala  Arg Val Cys Val Phe  Glu Gln Thr 
    1055                 1060                 1065             


Leu Glu  Leu Glu Glu Ser Leu  Leu Thr Arg Cys Pro  His Leu Pro 
    1070                 1075                 1080             


Asp Lys  Asn Phe Arg Lys Met  Leu Glu Ser Trp Ser  Asp Pro Leu 
    1085                 1090                 1095             


Leu Asp  Lys Trp Pro Asp Leu  His Gly Asn Val Arg  Leu Leu Ile 
    1100                 1105                 1110             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1115                 1120                 1125             


Glu Ala  Val Phe Ser Ser Ile  Arg Lys Tyr Asp Pro  Ser Ser Leu 
    1130                 1135                 1140             


Asp Ala  Ile Glu Glu Arg Met  Gly Leu Asn Ile Ala  His Arg Leu 
    1145                 1150                 1155             


Ser Glu  Glu Val Lys Gln Ala  Lys Glu Met Val Glu  Arg Ile Ile 
    1160                 1165                 1170             


Gln Val  
    1175 


<210>  2167
<211>  1113
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2167

Met Glu Asn Asp Lys Arg Leu Glu Glu Ser Ala Cys Tyr Thr Leu Asn 
1               5                   10                  15      


Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val 
            20                  25                  30          


Tyr Ile Thr Ile Asn His Ile Asn Lys Leu Leu Glu Ile Arg Gln Ile 
        35                  40                  45              


Asp Asn Asp Glu Lys Val Leu Asp Ile Lys Ala Leu Trp Gln Lys Val 
    50                  55                  60                  


Asp Lys Asp Ile Asn Gln Lys Ala Arg Leu Arg Glu Leu Met Ile Lys 
65                  70                  75                  80  


His Phe Pro Phe Leu Glu Phe Ala Ile Tyr Asn Asn Asn Lys Asp Gly 
                85                  90                  95      


Lys Gln Glu Glu Lys Gln Ala Lys Ala Gln Ser Phe Glu Ser Leu Lys 
            100                 105                 110         


Asp Cys Leu Phe Leu Phe Leu Lys Lys Leu Gln Glu Ser Arg Asn Tyr 
        115                 120                 125             


Tyr Ser His Tyr Lys Tyr Ser Glu Ser Ser Gln Glu Pro Lys Leu Glu 
    130                 135                 140                 


Lys Glu Leu Arg Lys Lys Met Tyr Asn Ile Phe Asp Ala Ser Ile Arg 
145                 150                 155                 160 


Leu Val Lys Glu Asp Tyr Gln Tyr Asn Lys Asp Ile Asp Pro Glu Lys 
                165                 170                 175     


Asp Phe Lys His Leu Glu Arg Lys Glu Asp Phe Asn Tyr Leu Phe Thr 
            180                 185                 190         


Asp Lys Asp Asn Lys Arg Lys Ile Thr Lys Asn Gly Leu Leu Phe Phe 
        195                 200                 205             


Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Met Gln Gln Lys 
    210                 215                 220                 


Leu Arg Gly Phe Lys Asp Asn Arg Gly Asn Lys Glu Lys Met Thr His 
225                 230                 235                 240 


Glu Val Phe Cys Arg Ser Arg Met Leu Leu Pro Lys Ile Arg Leu Glu 
                245                 250                 255     


Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu Asn Glu Leu 
            260                 265                 270         


Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Gln Gly Ala Tyr Arg 
        275                 280                 285             


Glu Lys Phe Lys Val Pro Phe Asp Ser Ile Asp Glu Asp Tyr Asp Ala 
    290                 295                 300                 


Glu Gln Glu Pro Phe Arg Asn Thr Leu Val Arg His Gln Asp Arg Phe 
305                 310                 315                 320 


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Tyr Asn Glu Ile Phe Lys Asn 
                325                 330                 335     


Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile Tyr Lys 
            340                 345                 350         


Lys Leu Ile Gly Asp Asn Lys Glu Asp Arg His Leu Thr His Lys Leu 
        355                 360                 365             


Tyr Gly Phe Glu Arg Ile Gln Glu Phe Ala Lys Gln Lys Arg Pro Asn 
    370                 375                 380                 


Glu Trp Gln Ala Leu Val Lys Asp Leu Asp Ile Tyr Glu Thr Ser Asn 
385                 390                 395                 400 


Glu Gln Tyr Ile Ser Glu Thr Thr Pro His Tyr His Leu Glu Asn Gln 
                405                 410                 415     


Lys Ile Gly Ile Arg Phe Lys Asn Lys Lys Asp Lys Ile Trp Pro Ser 
            420                 425                 430         


Leu Glu Thr Asn Gly Lys Glu Asn Glu Lys Ser Lys Tyr Asn Leu Asp 
        435                 440                 445             


Lys Ser Phe Gln Ala Glu Ala Phe Leu Ser Val His Glu Leu Leu Pro 
    450                 455                 460                 


Met Met Phe Tyr Tyr Leu Leu Leu Lys Lys Glu Glu Pro Asn Asn Asp 
465                 470                 475                 480 


Glu Lys Asn Ala Ser Ile Val Glu Gly Phe Ile Lys Lys Glu Ile Lys 
                485                 490                 495     


Arg Met Tyr Ala Ile Tyr Asp Ala Phe Ala Asn Glu Glu Ile Asn Ser 
            500                 505                 510         


Lys Glu Glu Leu Glu Glu Tyr Cys Lys Asn Lys Gly Leu Gln Glu Arg 
        515                 520                 525             


His Leu Pro Lys Gln Met Ile Ala Ile Leu Thr Asn Lys Ser Lys Asp 
    530                 535                 540                 


Met Val Lys Ala Ala Glu Arg Lys Gln Lys Glu Met Val Lys Asp Thr 
545                 550                 555                 560 


Lys Lys Arg Leu Ala Thr Leu Glu Lys Gln Thr Gln Gly Glu Ile Glu 
                565                 570                 575     


Asp Gly Gly Arg Asn Ile Arg Leu Leu Lys Ser Gly Glu Ile Ala Arg 
            580                 585                 590         


Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln Lys Asp Asn 
        595                 600                 605             


Glu Gly Lys Pro Gln Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln 
    610                 615                 620                 


Met Leu Gln Arg Ser Leu Ala Leu Tyr Asn Lys Glu Glu Lys Pro Thr 
625                 630                 635                 640 


Arg Tyr Phe Ile Gln Val Asn Leu Ile Lys Ser Ser Asn Pro His Pro 
                645                 650                 655     


Phe Leu Glu Asp Thr Lys Trp Glu Glu Cys Tyr Asn Ile Leu Ser Phe 
            660                 665                 670         


Tyr Arg Asn Tyr Leu Lys Ala Lys Ile Glu Phe Leu Asn Lys Leu Lys 
        675                 680                 685             


His Glu Asp Trp Lys Lys Asn Gln Tyr Phe Leu Met Leu Lys Glu Pro 
    690                 695                 700                 


Lys Thr Asn Arg Lys Thr Leu Val Gln Gly Trp Lys Asn Gly Phe Asn 
705                 710                 715                 720 


Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Lys Glu Trp Phe Lys Arg 
                725                 730                 735     


His Gln Asn Asp Ser Glu Glu Tyr Lys Lys Val Glu Ala Leu Asp Arg 
            740                 745                 750         


Val Gly Leu Ile Ala Lys Val Ile Pro Leu Phe Phe Lys Glu Glu Tyr 
        755                 760                 765             


Phe Lys Glu Asp Ala Gln Lys Glu Ile Asn Asn Cys Val Gln Pro Phe 
    770                 775                 780                 


Tyr Ser Phe Pro Tyr Asn Val Gly Asn Ile His Lys Pro Glu Glu Lys 
785                 790                 795                 800 


Asn Phe Leu His Cys Glu Glu Arg Arg Lys Leu Trp Asp Lys Lys Lys 
                805                 810                 815     


Asp Lys Phe Lys Gly Tyr Lys Ala Lys Glu Lys Thr Lys Lys Met Thr 
            820                 825                 830         


Asp Lys Glu Lys Glu Glu His Arg Ser Tyr Leu Val Phe Gln Ser Trp 
        835                 840                 845             


Lys Lys Phe Glu Arg Glu Leu Arg Leu Val Arg Asn Gln Asp Ile Val 
    850                 855                 860                 


Thr Trp Met Leu Cys Met Glu Leu Phe Asp Lys Leu Lys Val Glu Gly 
865                 870                 875                 880 


Leu Asn Val Glu Glu Leu Gln Lys Leu Arg Leu Lys Asp Ile Asp Thr 
                885                 890                 895     


Asp Thr Ala Lys Lys Glu Lys Asn Asn Ile Leu Asn Arg Ile Met Pro 
            900                 905                 910         


Met Gln Leu Pro Val Thr Val Tyr Glu Ile Asp Lys Ser Phe Asn Ile 
        915                 920                 925             


Val Lys Asp Lys Pro Leu His Thr Val Tyr Ile Glu Glu Thr Gly Thr 
    930                 935                 940                 


Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys Asp Arg Arg 
945                 950                 955                 960 


Leu Asn Gly Leu Phe Ser Phe Val Lys Thr Ser Ser Glu Ala Glu Ser 
                965                 970                 975     


Lys Ser Asn Pro Ile Ser Lys Leu Arg Val Glu Tyr Glu Leu Gly Ala 
            980                 985                 990         


Tyr Gln Lys Ala Arg Ile Asp Ile  Ile Lys Asp Met Leu  Ala Leu Glu 
        995                 1000                 1005             


Lys Thr  Leu Ile Asp Asn Asp  Glu Asn Leu Pro Thr  Asn Lys Phe 
    1010                 1015                 1020             


Ser Asp  Met Leu Lys Ser Trp  Leu Lys Gly Lys Gly  Glu Ala Asn 
    1025                 1030                 1035             


Lys Ala  Arg Leu Gln Asn Asp  Val Asp Leu Leu Val  Ala Val Arg 
    1040                 1045                 1050             


Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met Tyr Asn  Ser Glu Val 
    1055                 1060                 1065             


Phe Lys  Gly Met Lys Leu Leu  Ser Leu Ser Ser Asp  Ile Pro Glu 
    1070                 1075                 1080             


Lys Glu  Gly Leu Gly Ile Ala  Lys Gln Leu Lys Asp  Lys Ile Lys 
    1085                 1090                 1095             


Glu Thr  Ile Glu Arg Ile Ile  Glu Ile Glu Lys Glu  Ile Arg Asn 
    1100                 1105                 1110             


<210>  2168
<211>  1146
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2168

Met Glu Ser Ile Ile Gly Leu Gly Leu Ser Phe Asn Pro Tyr Lys Thr 
1               5                   10                  15      


Ala Asp Lys His Tyr Phe Gly Ser Phe Leu Asn Leu Ala Asp Asn Asn 
            20                  25                  30          


Leu Lys Ala Val Phe Ala Glu Phe Lys Glu Arg Ile Ser Asp Lys Ser 
        35                  40                  45              


Lys Asp Glu Asp Ile Ser Asn Leu Ile Glu Lys His Phe Ile Asp Asn 
    50                  55                  60                  


Met Ser Ile Val Asp Tyr Glu Lys Asn Ile Ser Ile Leu Asn Gly Tyr 
65                  70                  75                  80  


Leu Pro Ile Ile Asp Phe Leu Asp Asp Glu Leu Glu Asn Asn Leu Asn 
                85                  90                  95      


Thr Arg Val Lys Asn Phe Lys Lys Ser Phe Ile Ile Leu Ala Glu Ala 
            100                 105                 110         


Leu Glu Thr Leu Arg Asn Tyr Tyr Thr His Phe Tyr His Asp Pro Ile 
        115                 120                 125             


Thr Phe Gly Asp Asn Lys Glu Pro Leu Leu Glu Leu Leu Asp Glu Val 
    130                 135                 140                 


Leu Leu Lys Thr Ile Leu Asp Val Lys Lys Lys Tyr Leu Lys Thr Asp 
145                 150                 155                 160 


Lys Thr Lys Glu Ile Leu Lys Asp Ser Leu Arg Glu Glu Met Asp Leu 
                165                 170                 175     


Leu Val Ile Arg Lys Thr Asp Glu Leu Arg Glu Lys Lys Lys Thr Asn 
            180                 185                 190         


Pro Lys Phe Lys Phe Ser Thr Asp Pro Thr Gln Ile Arg Asn Ser Ile 
        195                 200                 205             


Phe Asn Asp Ala Phe Gln Gly Leu Leu Tyr Glu Asp Lys Glu Asn Asn 
    210                 215                 220                 


Gly Lys Thr Gln Val Ser Tyr Arg Ala Lys Thr Lys Leu Asn Pro Lys 
225                 230                 235                 240 


Asp Ile His Lys Gln Glu Glu Arg Asp Phe Glu Ile Pro Leu Ser Thr 
                245                 250                 255     


Ser Gly Ile Val Phe Leu Met Ser Leu Phe Leu Ser Lys Lys Glu Ile 
            260                 265                 270         


Glu Asp Phe Lys Ser Asn Ile Lys Gly Phe Lys Gly Lys Val Val Lys 
        275                 280                 285             


Asp Glu Asn His Asn Ser Leu Lys Tyr Met Ala Thr His Arg Val Tyr 
    290                 295                 300                 


Ser Ile Leu Ala Phe Lys Gly Leu Lys Tyr Arg Ile Lys Thr Asp Thr 
305                 310                 315                 320 


Phe Ser Lys Val Thr Leu Met Met Gln Met Ile Asp Glu Leu Ser Lys 
                325                 330                 335     


Val Pro Asp Cys Val Tyr Gln Asn Leu Ser Glu Thr Lys Gln Lys Asp 
            340                 345                 350         


Phe Ile Glu Asp Trp Asn Glu Tyr Leu Lys Asp Asn Glu Glu Asn Thr 
        355                 360                 365             


Glu Asn Leu Glu Asn Ser Arg Val Val His Pro Leu Ile Arg Lys Arg 
    370                 375                 380                 


Tyr Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe 
385                 390                 395                 400 


Ala Asn Phe Lys Thr Leu Lys Phe Gln Val Phe Met Gly Tyr Tyr Ile 
                405                 410                 415     


His Asp Gln Arg Thr Lys Thr Ile Gly Thr Thr Asn Ile Thr Thr Glu 
            420                 425                 430         


Arg Thr Val Lys Glu Lys Ile Asn Val Phe Gly Lys Leu Ser Lys Met 
        435                 440                 445             


Asp Asn Leu Lys Lys His Phe Phe Ser Gln Leu Ser Asp Glu Glu Asn 
    450                 455                 460                 


Thr Asp Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Phe Leu Thr Gln 
465                 470                 475                 480 


Ala Asp Asn Ser Pro Ala Asn Asn Ile Pro Ile Tyr Leu Glu Leu Lys 
                485                 490                 495     


Asn Gln Gln Ile Ile Lys Glu Lys Asp Asp Ile Lys Ala Glu Val Asn 
            500                 505                 510         


Asn Ser Gln Asn Arg Asn Pro Asn Lys Pro Ser Lys Arg Asp Leu Leu 
        515                 520                 525             


Asn Lys Ile Ser Asn Thr Asn Glu Asp Phe Tyr Gln Gly Asp Pro Thr 
    530                 535                 540                 


Ala Ile Leu Ser Leu Asn Glu Ile Pro Ala Leu Leu His Leu Phe Leu 
545                 550                 555                 560 


Val Gln Pro Asp Asn Lys Thr Gly Gln Gln Ile Glu Asn Ile Ile Arg 
                565                 570                 575     


Ile Lys Ile Glu Lys Gln Phe Asn Ser Ile Lys Asn Pro Ser Lys Asp 
            580                 585                 590         


Asp Lys Gly Val Pro Lys Ser Leu Phe Ala Asp Thr Asn Val Arg Val 
        595                 600                 605             


Asn Ala Ile Lys Leu Lys Lys Asp Leu Gly Glu Glu Leu Asp Met Leu 
    610                 615                 620                 


Asn Lys Lys Gln Ile Val Phe Lys Glu Asn Gln Lys Ala Ser Ser Asn 
625                 630                 635                 640 


Tyr Asp Glu Leu Leu Lys Lys His Gln Phe Thr Pro Lys Asn Lys Arg 
                645                 650                 655     


Pro Ala Leu Arg Lys Tyr Val Phe Tyr Asn Ser Glu Lys Gly Glu Glu 
            660                 665                 670         


Ala Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Lys Gly Phe 
        675                 680                 685             


Lys Thr Lys Trp Lys Gly Tyr Gln His Ser Glu Leu Gln Arg Lys Leu 
    690                 695                 700                 


Ala Phe Tyr Asp Arg His Thr Lys Gln Asp Ile Lys Glu Leu Leu Ser 
705                 710                 715                 720 


Gly Cys Glu Phe Asp His Phe Leu Leu Asp Ile Asn Ala Cys Phe Lys 
                725                 730                 735     


Glu Asp Asp Phe Glu Asp Phe Phe Ser Lys Tyr Leu Lys Asn Arg Ile 
            740                 745                 750         


Glu Thr Leu Asn Ile Ile Leu Lys Gln Leu His Asp Phe Lys Asn Glu 
        755                 760                 765             


Pro Thr Pro Leu Lys Gly Val Phe Lys Asn Cys Leu Lys Phe Leu Lys 
    770                 775                 780                 


Gln Lys Asn Tyr Val Thr Glu Asn Pro Glu Ile Ile Lys Lys Arg Ile 
785                 790                 795                 800 


Leu Ala Lys Pro Ala Phe Leu Pro Arg Gly Ile Phe Asp Glu Arg Pro 
                805                 810                 815     


Thr Met Lys Lys Gly Lys Asn Pro Leu Ile Asp Arg Asp Glu Phe Ala 
            820                 825                 830         


Lys Trp Phe Val Glu Tyr Leu Glu Asn Lys Asp Tyr Gln Lys Phe Tyr 
        835                 840                 845             


Asn Ser Glu Glu Tyr Arg Ile Arg Asp Ala Asp Phe Lys Lys Asn Ala 
    850                 855                 860                 


Val Ile Lys Lys Gln Lys Leu Lys Asp Phe Tyr Thr Leu Gln Met Val 
865                 870                 875                 880 


Asn Tyr Leu Leu Lys Glu Val Phe Gly Lys Asp Glu Met Asn Leu Gln 
                885                 890                 895     


Leu Ser Glu Leu Phe Gln Thr Arg Gln Glu Arg Leu Lys Leu Gln Gly 
            900                 905                 910         


Ile Ala Lys Lys Gln Met Asn Lys Glu Thr Gly Asp Ser Ser Glu Asn 
        915                 920                 925             


Thr Arg Asn Gln Thr Tyr Ile Trp Asn Lys Asp Val Pro Val Ser Phe 
    930                 935                 940                 


Phe Asn Gly Lys Val Thr Ile Asp Lys Val Lys Leu Lys Asn Ile Gly 
945                 950                 955                 960 


Lys Tyr Lys Arg Tyr Glu Arg Asp Glu Arg Val Lys Thr Phe Ile Gly 
                965                 970                 975     


Tyr Glu Val Asp Glu Lys Trp Met Met Tyr Leu Pro His Asn Trp Lys 
            980                 985                 990         


Asp Arg Tyr Ser Val Lys Pro Ile  Asn Val Ile Asp Leu  Gln Ile Gln 
        995                 1000                 1005             


Glu Tyr  Glu Glu Ile Arg Ser  His Glu Leu Leu Lys  Glu Ile Gln 
    1010                 1015                 1020             


Asn Leu  Glu Gln Tyr Ile Tyr  Asp His Thr Thr Asp  Lys Asn Thr 
    1025                 1030                 1035             


Leu Leu  Gln Asp Gly Asn Pro  Asn Phe Lys Met Tyr  Val Leu Asn 
    1040                 1045                 1050             


Gly Leu  Leu Thr Gly Ile Lys  Gln Val Asn Ile Ala  Asp Phe Ile 
    1055                 1060                 1065             


Val Leu  Lys Gln Asn Thr Asn  Phe Asp Lys Ile Asp  Phe Thr Gly 
    1070                 1075                 1080             


Ile Ala  Ser Cys Ser Glu Leu  Glu Lys Lys Thr Ile  Ile Leu Ile 
    1085                 1090                 1095             


Ala Ile  Arg Asn Lys Phe Ala  His Asn Gln Leu Pro  Asn Lys Thr 
    1100                 1105                 1110             


Ile Tyr  Asp Leu Ala Asn Glu  Phe Leu Lys Lys Glu  Lys Arg Glu 
    1115                 1120                 1125             


Thr Tyr  Ala Asn Tyr Tyr Leu  Lys Val Leu Lys Lys  Met Ile Ser 
    1130                 1135                 1140             


Asp Leu  Ala 
    1145     


<210>  2169
<211>  1140
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2169

Met Glu Asn Asp Gln Gln Ile Leu Glu Asn Arg Arg Arg Thr Leu Ala 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Ser Asn His Leu Ala Ala Ser Phe Glu Gln Lys Val 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ala Ser Phe Leu Cys Asn Lys Ser 
    50                  55                  60                  


Ile Lys Lys Ile Asn Trp Asn His Val Tyr Ser Lys Ala Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ala Asp Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Arg Glu Thr Thr Asp Lys Glu Gly Lys Asp Phe Thr Ala Met Asn Glu 
            100                 105                 110         


Thr Leu Lys Leu Val Phe Asp Glu Leu Gln Ala Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Ala Asp Ser Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Val Glu Leu Ala Asp Phe Leu Thr Val Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Ala Asp Asp Asp Tyr 
                165                 170                 175     


Thr Met Val Glu Ser Lys Gln Ile Val Thr Pro Asp Asn Leu Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Val Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Leu Ala Tyr Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asp Leu Gly Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Glu 
            260                 265                 270         


Val Ile Thr Glu Glu Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Glu Glu Glu Arg 
    290                 295                 300                 


Glu Lys Ile Leu Asp Glu Ile Asp Tyr Glu Asp Tyr Ile Glu Ser Leu 
305                 310                 315                 320 


Thr Arg Arg Val Arg His Ser Asn Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Lys Tyr Asn Lys Gln Phe Asp Gly Glu 
        355                 360                 365             


Ala Thr Glu Cys Lys Val Val Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asn Gln Glu Thr Val Glu Leu Lys Ile Asp Ser Ala 
385                 390                 395                 400 


Gln Arg Thr Asn Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Glu Ala Arg Leu Leu 
            420                 425                 430         


Thr Lys Ala Lys Pro Glu Ser Lys Val Ser Tyr Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Lys Ala Glu Glu Met Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Lys Val Asn Asp Ser Gln Leu Met Ser Met Gln Phe Ile Asp Glu 
                485                 490                 495     


Ile Lys Glu Gln Leu Pro Ala Asp Trp Asn Glu Phe Gly Lys Arg Ser 
            500                 505                 510         


Asp Ser Lys Lys Lys Lys Ala Tyr Thr Asn Ala Ala Leu Gln Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Lys Val Leu Ala Asn Tyr Gln Leu 
    530                 535                 540                 


Asn Asp Lys Gln Val Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Ser Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Val Glu Lys His Lys Leu 
            580                 585                 590         


Asp Lys Ser Ala Arg Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Thr Asp Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Phe Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Tyr 
625                 630                 635                 640 


Ala Asp Thr Asp Lys Lys Ala Thr Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Lys Gly Gly His Pro Phe Leu Ala Asn Ile Asn 
            660                 665                 670         


Leu Arg Gln Ile Arg Lys Thr Ser Gln Leu Tyr Glu Leu Tyr Leu Val 
        675                 680                 685             


Glu Lys Ala Asn Lys Gln Val Lys Lys Met Asn Pro Lys Thr Gln Arg 
    690                 695                 700                 


Thr Ser Asn Val Asp Glu Ser Trp Met Met Lys Ser Phe Tyr Ala Lys 
705                 710                 715                 720 


Glu Trp Asn Glu Glu Met Gly Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Val Asn Lys Thr Asn Ile Pro Phe Thr Ile Arg Gln Trp Glu Glu Lys 
            740                 745                 750         


Glu Lys His Asn Leu Gln Ala Trp Leu His Asn Ile Thr Lys Gly Lys 
        755                 760                 765             


Thr Ser Lys Asp Gly Lys Lys Ala Ile Asp Leu Pro Thr Asn Leu Phe 
    770                 775                 780                 


Asp Asp Thr Leu Cys Glu Leu Leu Arg Glu Ala Leu Ile Asn Gln Gly 
785                 790                 795                 800 


Ile Asp Ala Thr Pro Thr Thr Lys Tyr Asn Glu Leu Leu Lys Gln Trp 
                805                 810                 815     


Trp Thr Ala Arg Glu Asp Ser Thr Gln Asp Phe Tyr Leu Ser Glu Arg 
            820                 825                 830         


Gln Tyr Asp Ile Tyr Asp Glu Lys Val Cys Phe Thr Ile Asn Ser Ser 
        835                 840                 845             


Ala His Phe Ala Asp Tyr Tyr Ala Pro Ala Leu Asn Lys Ala Tyr Ser 
    850                 855                 860                 


Arg Leu Arg Ala Glu Arg Asp Val Ala Arg Arg Thr Asp Lys Arg Leu 
865                 870                 875                 880 


Pro Pro Val Glu Arg Lys Asp Val Glu Arg Val Phe Lys Asn Thr Ile 
                885                 890                 895     


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
            900                 905                 910         


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asn Gln Gln Gln Leu Lys 
        915                 920                 925             


Leu Ser Lys Met Asp Ser Leu Leu Asn Glu Thr Lys Arg Ile Glu Gln 
    930                 935                 940                 


Thr Ile Asn Thr Gln Leu Ser Phe Asp His Lys Gly Lys Glu Ile Lys 
945                 950                 955                 960 


Asp Lys Thr Asn Ser Glu Ile Val Lys Thr Ile Val Ala Glu Arg Lys 
                965                 970                 975     


Gln Lys Asn Tyr Thr Glu Met Arg Lys Tyr Val His Asp Arg Arg Leu 
            980                 985                 990         


Pro Glu Leu Phe Glu Tyr Ile Asp  Gly Asn Glu Leu Pro  Leu Asp Val 
        995                 1000                 1005             


Leu Leu  Asn Glu Leu Arg Ala  Tyr Asn Thr Ala Lys  Gln Met Val 
    1010                 1015                 1020             


Phe Asp  Thr Val Phe Ala Leu  Glu Lys Lys Ile Ile  Glu Thr Asp 
    1025                 1030                 1035             


Pro Glu  Gly Leu Lys Gln Leu  Asn Val Gly Lys Asn  Gly Gln Ile 
    1040                 1045                 1050             


Gln Thr  Gly Asn Ile Gln His  Lys Pro Tyr Val Gln  Trp Leu Glu 
    1055                 1060                 1065             


Asn Lys  Gly Leu Ile Thr Asp  His Gln Lys Gln Phe  Ile Asn Met 
    1070                 1075                 1080             


Val Arg  Asn Ser Phe Ser His  Asn Gln Phe Pro Gln  Arg Ser Thr 
    1085                 1090                 1095             


Val Glu  Leu Leu Met Pro Glu  Trp Gln Asn Thr Asp  Ile Ala Leu 
    1100                 1105                 1110             


Gln Ile  Ala Arg Glu Tyr Gln  Gln Leu Ile Val Asp  Ile Ile Glu 
    1115                 1120                 1125             


Lys Ser  Leu His Pro His Lys  Gln His Gln Met Val  
    1130                 1135                 1140 


<210>  2170
<211>  1137
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2170

Met Glu Asn Asn Asn Leu Gly Asn Gly Ile Val Tyr Asp Tyr Ala Ile 
1               5                   10                  15      


Ile Ala Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Lys Asp 
            20                  25                  30          


Asn Ile Asp Ala Val Phe Lys Ala Tyr Glu Asp Arg Phe Gly Glu Asn 
        35                  40                  45              


Val Pro Asp Met Lys Ile Glu Asn Leu Ser Tyr Gln Asp Tyr Gln Asn 
    50                  55                  60                  


Arg Ile Asp Phe Leu Lys Tyr Tyr Phe Pro Val Ile Asn Tyr Leu Asp 
65                  70                  75                  80  


Leu Pro Val Ser Asp Lys Glu Phe Glu Asn Ile Arg Asp Lys Glu Pro 
                85                  90                  95      


Lys Arg Arg Lys Tyr Phe Arg Glu Asn Phe Lys Thr Leu Tyr Lys Ala 
            100                 105                 110         


Val Ser Ala Leu Arg His Phe Tyr Thr His Tyr Tyr His Glu Pro Leu 
        115                 120                 125             


Ser Phe Glu Met Asn Leu Phe Ser Leu Leu Asp Lys Ile Phe Ile Ser 
    130                 135                 140                 


Val Ile Glu Asp Ile Lys Lys Glu Lys Lys Asn Asp Asn Lys Thr Arg 
145                 150                 155                 160 


Pro Leu Leu Asn Arg Asn Leu Lys Glu Glu Leu Lys Cys Leu Met Ala 
                165                 170                 175     


Leu Lys Lys Gln Glu Leu Lys Glu Lys Gln Lys Ser Gln Lys Asn Ile 
            180                 185                 190         


Ser Leu Asp Glu Val Ser Ile Gln Asn Ala Val Phe Asn Asp Ala Phe 
        195                 200                 205             


Ser Gln Phe Phe Asn Lys Glu Lys Lys Ile Ser Arg Phe Tyr Gln Ala 
    210                 215                 220                 


Glu Asn Thr Asp Thr Asp Ile Glu Asn Lys Leu Asn Ile Ser Gln Thr 
225                 230                 235                 240 


Gly Leu Leu Phe Leu Leu Gly Met Phe Leu Thr Lys Lys Gln Ser Glu 
                245                 250                 255     


Asp Leu Arg Ser Arg Ile Arg Arg Phe Lys Asn Lys Ile Ile Lys Asn 
            260                 265                 270         


Gln Asp His Pro Val Ser Lys Gln Asn Asn Ser Leu Lys Tyr Met Ser 
        275                 280                 285             


Thr Gln Trp Val Phe Gly Tyr Leu Ala Phe Lys Gly Leu Lys Ser Thr 
    290                 295                 300                 


Leu Asn Thr Thr Phe Met Gln Glu Thr Leu Leu Thr Gln Ile Val Asp 
305                 310                 315                 320 


Glu Leu Ser Lys Val Pro Asn Glu Ile Tyr Arg Asn Leu Ser Gln Glu 
                325                 330                 335     


Gln Gln Gln Leu Phe Ile Glu Asp Met Asn Glu Tyr Val Gln Asp Gly 
            340                 345                 350         


Asn Asn Val Lys Ser Leu Glu Asp Ala Ile Val Ile His Pro Val Ile 
        355                 360                 365             


Arg Lys Arg Tyr Glu Asp Lys Phe Pro Tyr Phe Val Ile Arg Tyr Leu 
    370                 375                 380                 


Asp Glu Tyr Ala Gly Phe Pro Thr Leu Lys Phe Gln Ile Gln Leu Gly 
385                 390                 395                 400 


Asn Tyr Val His Asp Lys Arg Thr Lys Lys Ile Gln Gly Thr Val Tyr 
                405                 410                 415     


Ser Thr Glu Arg Val Val Lys Glu Lys Ile Thr Val Phe Gly Lys Leu 
            420                 425                 430         


Ser Glu Ile Thr Ala Leu Lys Asp Asn Tyr Leu Lys Lys Arg Thr Gln 
        435                 440                 445             


Asn Asn Glu Glu Asn Arg Gly Trp Glu Ile Tyr Pro Asn Pro Ser Tyr 
    450                 455                 460                 


Asn Phe Thr Gly Asn Asn Ile Pro Ile Tyr Leu Asp Leu Glu Ser Ser 
465                 470                 475                 480 


Asn Val Pro Gly Ala Lys Gln Leu Tyr Gly Asn Ile Gln Lys Gln Cys 
                485                 490                 495     


Ala Asp Leu Arg Lys Lys Asn Ile Glu Asn Gln Asp Gln Thr Glu Arg 
            500                 505                 510         


Ala Asp Lys Ala Thr Lys His Asp Ile Val Lys Leu Ile Asp Ser Lys 
        515                 520                 525             


Lys Ile Val Ile Lys Lys Pro Thr Ala Phe Leu Ser Leu Asn Glu Leu 
    530                 535                 540                 


Ser Gly Leu Leu Tyr Glu Leu Leu Val Asn Lys Lys Asn Gly Lys Gln 
545                 550                 555                 560 


Ile Glu Asp Ile Leu Ile Lys Lys Leu Ile Glu His Tyr Asp Thr Ile 
                565                 570                 575     


Ser Glu Phe Ser Thr Glu Asn Pro Leu Pro Thr Ser Gln Ile Thr Lys 
            580                 585                 590         


Lys Leu Leu Lys Ser Asn Ser Glu Ser Gln Trp Asn Thr Gly Lys Leu 
        595                 600                 605             


Met Arg Asp Ile Glu Arg Glu Ile Ala Val Thr Glu His Lys Leu Asn 
    610                 615                 620                 


Leu Ile Lys Asp Lys Arg Asp Ser Leu Ser Arg Tyr Asn Leu Lys Glu 
625                 630                 635                 640 


Lys Ile Arg Lys Pro Val Phe Ser Asn Arg Ala Ala Gly Lys Glu Ala 
                645                 650                 655     


Val Trp Ile Ala Glu Asp Leu Val Arg Phe Met Pro Lys Ala Val Arg 
            660                 665                 670         


Lys Asn Trp Lys Gly Tyr His His Ser Gln Leu Gln Gln Ser Leu Ala 
        675                 680                 685             


Phe Tyr Glu Gln Arg Pro Asn Glu Ala Val Asn Leu Val Lys Gln Tyr 
    690                 695                 700                 


Trp Asn Leu Asn Asp Thr Arg Tyr Cys Trp Asn Glu Gly Ile Lys Lys 
705                 710                 715                 720 


Ser Phe Glu Arg Ser Glu Phe Asp Leu Phe Tyr Glu Ala Tyr Leu Lys 
                725                 730                 735     


Asn Arg Lys Lys Ile Leu Asn Leu Tyr Arg Asp Lys Leu Ser Asp Asn 
            740                 745                 750         


Met Glu Asn Met Glu Ser Met Met Gln Asp Glu His Leu Asp Phe Ile 
        755                 760                 765             


Phe Asn Arg His Leu Tyr Lys Ile Asp Thr Thr Glu Asn Gln Lys Leu 
    770                 775                 780                 


Lys Leu Leu Ala His Pro Phe Val Phe Pro Arg Gly Ile Phe Asp Glu 
785                 790                 795                 800 


Lys Pro Thr Tyr Ile Lys Gly Lys Ser Met Thr Glu Thr Pro Glu Leu 
                805                 810                 815     


Tyr Ala Glu Trp Tyr Arg Tyr Ala Asn Gln Arg Ile Glu Ser Gln Gln 
            820                 825                 830         


Phe Phe Tyr Lys Thr Pro Arg Asp Tyr Lys Asp Leu Tyr Asn Thr Met 
        835                 840                 845             


Lys Glu His Lys Lys Glu Ile Asp Glu Asn Lys Tyr Asn Leu Ser Glu 
    850                 855                 860                 


Ile Glu Lys Tyr Asn Leu Phe Lys Asn Lys Gln Asp Lys Ala Ile Lys 
865                 870                 875                 880 


Lys Val Gln Met Gln Asp Val Phe Leu Glu Leu Ile Val Lys Asp Leu 
                885                 890                 895     


Phe Asn Arg Ile Phe Pro Asn Gln Gly Cys Asp Phe Ser Leu Lys Asp 
            900                 905                 910         


Phe Thr Asp Ile His Asn Asp Thr Trp Asn Ile Ser Val Pro Phe Gln 
        915                 920                 925             


Trp Lys Gln Ile Arg Glu Pro Glu Val Lys Leu Lys Asp Ile Gly Lys 
    930                 935                 940                 


Phe Lys Arg Phe Leu Phe Asp Lys Lys Ile Glu Asn Ile Leu Ser Tyr 
945                 950                 955                 960 


Asn Glu Asp Lys Ile Trp Thr Lys Arg Glu Leu Glu Glu Glu Leu Glu 
                965                 970                 975     


Leu Leu Pro Ser Ser Tyr Glu Val Ile Arg Arg Glu Gln Leu Leu Lys 
            980                 985                 990         


Leu Ile Gln Glu Leu Glu Asn Cys  Ile Leu Gln Lys Asn  Asn Phe Asp 
        995                 1000                 1005             


Gly Val  Asn His Pro Lys Glu  Phe Glu Gln Ser Asp  Glu Asp Lys 
    1010                 1015                 1020             


Lys Ala  Tyr Pro Asn Phe Lys  His Tyr Ile Thr Glu  Gly Ile Leu 
    1025                 1030                 1035             


Lys Lys  Cys Thr Leu Ala Glu  Asn Thr Asp Ile Glu  Trp Leu Asn 
    1040                 1045                 1050             


Gln Leu  Lys Glu Asp Thr Phe  Glu Lys Val Pro Leu  Gln Glu Leu 
    1055                 1060                 1065             


Cys Met  Lys Pro Lys Ile Ile  Gln Lys Ala Tyr Leu  Leu Val Leu 
    1070                 1075                 1080             


Ile Arg  Asn Lys Ile Ser His  Asn Gln Leu Pro Lys  Lys Glu Tyr 
    1085                 1090                 1095             


Phe Glu  Arg Ile Lys Thr Met  Phe Ser Pro Ala Glu  Ala Asn Glu 
    1100                 1105                 1110             


Thr Ile  Ser Tyr Ser Ser Ile  Ile Leu Asn Phe Thr  Lys Ser Val 
    1115                 1120                 1125             


Ile Gln  Glu Leu Lys Thr Tyr  Leu Lys 
    1130                 1135         


<210>  2171
<211>  1137
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2171

Met Glu Asn Asn Asn Leu Gly Asn Gly Ile Val Tyr Asp Tyr Ala Ile 
1               5                   10                  15      


Ile Ala Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Lys Asp 
            20                  25                  30          


Asn Ile Asp Ala Val Phe Lys Ala Tyr Glu Asp Arg Phe Gly Glu Asn 
        35                  40                  45              


Val Pro Asp Met Lys Ile Glu Asn Leu Ser Tyr Gln Asp Tyr Gln Asn 
    50                  55                  60                  


Arg Ile Asp Phe Leu Lys Tyr Tyr Phe Pro Val Ile Asn Tyr Leu Asp 
65                  70                  75                  80  


Leu Pro Val Ser Asp Lys Glu Phe Glu Asn Ile Arg Asp Lys Glu Pro 
                85                  90                  95      


Lys Arg Arg Lys Tyr Phe Arg Glu Asn Phe Lys Thr Leu Tyr Lys Ala 
            100                 105                 110         


Val Ser Ala Leu Arg His Phe Tyr Thr His Tyr Tyr His Glu Pro Leu 
        115                 120                 125             


Ser Phe Glu Met Asn Leu Phe Ser Leu Leu Asp Lys Ile Phe Ile Ser 
    130                 135                 140                 


Val Ile Glu Asp Ile Lys Lys Glu Lys Lys Asn Asp Asn Lys Thr Arg 
145                 150                 155                 160 


Pro Leu Leu Asn Arg Asn Leu Lys Glu Glu Leu Lys Cys Leu Met Ala 
                165                 170                 175     


Leu Lys Lys Gln Glu Leu Lys Glu Lys Gln Lys Ser Gln Lys Asn Ile 
            180                 185                 190         


Ser Leu Asp Glu Val Ser Ile Gln Asn Ala Val Phe Asn Asp Ala Phe 
        195                 200                 205             


Ser Gln Phe Phe Asn Lys Glu Lys Lys Ile Ser Arg Phe Tyr Gln Ala 
    210                 215                 220                 


Glu Asn Thr Asp Thr Asp Ile Glu Asn Lys Leu Asn Ile Ser Gln Thr 
225                 230                 235                 240 


Gly Leu Leu Phe Leu Leu Gly Met Phe Leu Thr Lys Lys Gln Ser Glu 
                245                 250                 255     


Asp Leu Arg Ser Arg Ile Arg Arg Phe Lys Asn Lys Ile Ile Lys Asn 
            260                 265                 270         


Gln Asp His Pro Val Ser Lys Gln Asn Asn Ser Leu Lys Tyr Met Ser 
        275                 280                 285             


Thr Gln Trp Val Phe Gly Tyr Leu Ala Phe Lys Gly Leu Lys Ser Thr 
    290                 295                 300                 


Leu Asn Thr Thr Phe Met Gln Glu Thr Leu Leu Thr Gln Ile Val Asp 
305                 310                 315                 320 


Glu Leu Ser Lys Val Pro Asn Glu Ile Tyr Arg Asn Leu Ser Gln Glu 
                325                 330                 335     


Gln Gln Gln Leu Phe Ile Glu Asp Met Asn Glu Tyr Val Gln Asp Gly 
            340                 345                 350         


Asn Asn Val Lys Ser Leu Glu Asp Ala Ile Val Ile His Pro Val Ile 
        355                 360                 365             


Arg Lys Arg Tyr Glu Asp Lys Phe Pro Tyr Phe Val Ile Arg Tyr Leu 
    370                 375                 380                 


Asp Glu Tyr Ala Gly Phe Pro Thr Leu Lys Phe Gln Ile Gln Leu Gly 
385                 390                 395                 400 


Asn Tyr Val His Asp Lys Arg Thr Lys Lys Ile Gln Gly Thr Val Tyr 
                405                 410                 415     


Ser Thr Glu Arg Val Val Lys Glu Lys Ile Thr Val Phe Gly Lys Leu 
            420                 425                 430         


Ser Glu Ile Thr Ala Leu Lys Asp Asn Tyr Leu Lys Lys Arg Thr Gln 
        435                 440                 445             


Asn Asn Glu Glu Asn Arg Gly Trp Glu Ile Tyr Pro Asn Pro Ser Tyr 
    450                 455                 460                 


Asn Phe Thr Gly Asn Asn Ile Pro Ile Tyr Leu Asp Leu Glu Ser Ser 
465                 470                 475                 480 


Asn Val Pro Gly Ala Lys Gln Leu Tyr Gly Asn Ile Gln Lys Gln Cys 
                485                 490                 495     


Ala Asp Leu Arg Lys Lys Asn Ile Glu Asn Gln Asp Gln Thr Glu Arg 
            500                 505                 510         


Ala Asp Lys Ala Thr Lys His Asp Ile Val Lys Leu Ile Asp Ser Lys 
        515                 520                 525             


Lys Ile Val Ile Lys Lys Pro Thr Ala Phe Leu Ser Leu Asn Glu Leu 
    530                 535                 540                 


Ser Gly Leu Leu Tyr Glu Leu Leu Val Asn Lys Lys Asn Gly Lys Gln 
545                 550                 555                 560 


Ile Glu Asp Ile Leu Ile Lys Lys Leu Ile Glu His Tyr Asp Thr Ile 
                565                 570                 575     


Ser Glu Phe Ser Thr Glu Asn Pro Leu Pro Thr Ser Gln Ile Thr Lys 
            580                 585                 590         


Lys Leu Leu Lys Ser Asn Ser Glu Ser Gln Trp Asn Thr Gly Lys Leu 
        595                 600                 605             


Met Arg Asp Ile Glu Arg Glu Ile Ala Val Thr Glu His Lys Leu Asn 
    610                 615                 620                 


Leu Ile Lys Asp Lys Arg Asp Ser Leu Ser Arg Tyr Asn Leu Lys Glu 
625                 630                 635                 640 


Lys Ile Arg Lys Pro Val Phe Ser Asn Arg Ala Ala Gly Lys Glu Ala 
                645                 650                 655     


Val Trp Ile Ala Glu Asp Leu Val Arg Phe Met Pro Lys Ala Val Arg 
            660                 665                 670         


Lys Asn Trp Lys Gly Tyr His His Ser Gln Leu Gln Gln Ser Leu Ala 
        675                 680                 685             


Phe Tyr Glu Gln Arg Pro Asn Glu Ala Val Asn Leu Val Lys Gln Tyr 
    690                 695                 700                 


Trp Asn Leu Asn Asp Thr Arg Tyr Cys Trp Asn Glu Gly Ile Lys Lys 
705                 710                 715                 720 


Ser Phe Glu Arg Ser Glu Phe Asp Leu Phe Tyr Glu Ala Tyr Leu Lys 
                725                 730                 735     


Asn Arg Lys Lys Ile Leu Asn Leu Tyr Arg Asp Lys Leu Ser Asp Asn 
            740                 745                 750         


Met Glu Asn Met Glu Ser Met Met Gln Asp Glu His Leu Asp Phe Ile 
        755                 760                 765             


Phe Asn Arg His Leu Tyr Lys Ile Asp Thr Thr Glu Asn Gln Lys Leu 
    770                 775                 780                 


Lys Leu Leu Ala His Pro Phe Val Phe Pro Arg Gly Ile Phe Asp Glu 
785                 790                 795                 800 


Lys Pro Thr Tyr Ile Lys Gly Lys Ser Met Thr Glu Thr Pro Glu Leu 
                805                 810                 815     


Tyr Ala Glu Trp Tyr Arg Tyr Ala Asn Gln Arg Ile Glu Ser Gln Gln 
            820                 825                 830         


Phe Phe Tyr Lys Thr Pro Arg Asp Tyr Lys Asp Leu Tyr Asn Thr Met 
        835                 840                 845             


Lys Glu His Lys Lys Glu Ile Asp Glu Asn Lys Tyr Asn Leu Ser Glu 
    850                 855                 860                 


Ile Glu Lys Tyr Asn Leu Phe Lys Asn Lys Gln Asp Lys Ala Ile Lys 
865                 870                 875                 880 


Lys Val Gln Met Gln Asp Val Phe Leu Glu Leu Ile Val Lys Asp Leu 
                885                 890                 895     


Phe Asn Arg Ile Phe Pro Asn Gln Gly Cys Asp Phe Ser Leu Lys Asp 
            900                 905                 910         


Phe Thr Asp Ile His Asn Asp Thr Trp Asn Ile Ser Val Pro Phe Gln 
        915                 920                 925             


Trp Lys Gln Ile Arg Glu Pro Glu Val Lys Leu Lys Asp Ile Gly Lys 
    930                 935                 940                 


Phe Lys Arg Phe Leu Phe Asp Lys Lys Ile Glu Asn Ile Leu Ser Tyr 
945                 950                 955                 960 


Asn Glu Asp Lys Ile Trp Thr Lys Arg Glu Leu Glu Glu Glu Leu Glu 
                965                 970                 975     


Leu Leu Pro Ser Ser Tyr Glu Val Ile Arg Arg Glu Gln Leu Leu Lys 
            980                 985                 990         


Leu Ile Gln Glu Leu Glu Asn Cys  Ile Leu Gln Lys Asn  Asn Phe Asp 
        995                 1000                 1005             


Gly Val  Asn His Pro Lys Glu  Phe Glu Gln Ser Asp  Glu Asp Lys 
    1010                 1015                 1020             


Lys Ala  Tyr Pro Asn Phe Lys  His Tyr Ile Thr Glu  Gly Ile Leu 
    1025                 1030                 1035             


Lys Lys  Cys Thr Leu Ala Glu  Asn Thr Asp Ile Glu  Trp Leu Asn 
    1040                 1045                 1050             


Gln Leu  Lys Glu Asp Thr Phe  Glu Lys Val Pro Leu  Gln Glu Leu 
    1055                 1060                 1065             


Cys Met  Lys Pro Lys Ile Ile  Gln Lys Ala Tyr Leu  Leu Val Leu 
    1070                 1075                 1080             


Ile Arg  Asn Lys Ile Ser His  Asn Gln Leu Pro Lys  Lys Glu Tyr 
    1085                 1090                 1095             


Phe Glu  Arg Ile Lys Thr Met  Phe Ser Pro Ala Glu  Ala Asn Glu 
    1100                 1105                 1110             


Thr Ile  Ser Tyr Ser Ser Ile  Ile Leu Asn Phe Thr  Lys Ser Val 
    1115                 1120                 1125             


Ile Gln  Glu Leu Lys Thr Tyr  Leu Lys 
    1130                 1135         


<210>  2172
<211>  1117
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2172

Met Glu Thr Met Asn Ala Leu Leu Glu Lys Lys Met Arg Thr Ile Gly 
1               5                   10                  15      


Asp Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Met Arg His Asn 
            20                  25                  30          


Ile Phe Ser Ile Ser Asn His Leu Ala Gln Lys Phe Asp Gln Ala Leu 
        35                  40                  45              


Leu Arg Asp Glu Met Asn Ile Ala Gly Ser Phe Leu Cys Asn Tyr Glu 
    50                  55                  60                  


Ile Lys Asn Val Asn Trp Asn His Ile Phe Arg His Ala Val Arg Phe 
65                  70                  75                  80  


Met Pro Val Ile Lys Ile Phe Asn Phe Glu Gln Leu Pro Ala Ser Val 
                85                  90                  95      


Arg Val His Glu Glu Ser Glu Lys Lys Val Pro Asp Gln Thr Met Asp 
            100                 105                 110         


Phe Arg Lys Thr Cys Ser Thr Leu Gly Glu Val Phe Lys Asp Leu Arg 
        115                 120                 125             


Asp Phe Arg Asn Asp Tyr Thr His Tyr Phe Ser Thr Asp Lys Gly Ala 
    130                 135                 140                 


Ser Arg Lys Ile Glu Val Ser Pro Val Thr Ala Asp Phe Leu Asn Asp 
145                 150                 155                 160 


Ala Phe Arg Leu Ala Ile Asp Tyr Thr Lys Glu Arg Met Lys Asp Val 
                165                 170                 175     


Leu Lys Glu Glu Asp Tyr Lys Leu Val Glu Arg Lys Val Met Phe Asp 
            180                 185                 190         


Ala Asp Arg His Ile Thr Thr Glu Gly Leu Val Phe Leu Ile Cys Met 
        195                 200                 205             


Phe Leu Glu Arg Glu Asp Ala Phe Arg Phe Ile Gly Lys Val Lys Gly 
    210                 215                 220                 


Leu Lys Gly Thr Gln Tyr Ser Thr Phe Ile Ala Thr Arg Glu Val Leu 
225                 230                 235                 240 


Met Ala Tyr Cys Val Lys Leu Pro His Asp Lys Phe Ile Asn Glu Asp 
                245                 250                 255     


Ala Lys Gln Asp Leu Thr Leu Asn Ile Ile Asn Glu Leu Asn Arg Cys 
            260                 265                 270         


Pro Lys Thr Leu Tyr His Val Ile Ser Glu Arg Asp Lys Lys Arg Phe 
        275                 280                 285             


Arg Pro Glu Leu Asp Leu Asp Lys Lys Arg Arg Ile Ile Asp Ser Ser 
    290                 295                 300                 


Thr Asp Arg Asp Asp Thr Glu Ser Trp Glu Glu Pro Asp Phe Glu Thr 
305                 310                 315                 320 


Tyr Val Glu Glu Ile Thr Lys Gln Val Arg Tyr Glu Asn Arg Phe Ser 
                325                 330                 335     


Tyr Phe Ala Met Arg Phe Ile Asp Glu Thr Asn Met Phe Ser Ser Leu 
            340                 345                 350         


Arg Phe Gln Ile Asp Leu Gly Lys Leu Glu Leu Ala Ile Tyr Asn Lys 
        355                 360                 365             


Met Leu Ala Gly Glu Glu Val Lys Arg Arg Val Val Glu Asn Val Lys 
    370                 375                 380                 


Val Phe Gly Lys Leu Arg Asp Tyr Leu Gln Glu Ala Thr Val Leu Ser 
385                 390                 395                 400 


Leu Ile Asp His Gln Ser Leu Ser Thr Gly Phe Val Gln Phe Ala Pro 
                405                 410                 415     


His Tyr Asn Ala Gln Asn Asn Arg Ile Gly Leu Ser Arg Arg Ser Arg 
            420                 425                 430         


Asn Ala Leu Leu Met Lys Lys Glu Val Leu Thr Asn Asn Ile His Leu 
        435                 440                 445             


Lys Leu Ile Gln His Gln Pro Asp Val Phe Leu Ser Leu His Glu Leu 
    450                 455                 460                 


Pro Lys Ile Ile Leu Leu Glu Tyr Leu Gln Arg Gly Glu Ala Glu Lys 
465                 470                 475                 480 


Met Ile Glu Trp Phe Ile Asp Ile Asn Glu Lys Leu Leu Thr Arg Gly 
                485                 490                 495     


Phe Ile Glu Glu Val Arg Leu Lys Leu Pro Asp Ser Trp Ser Asp Phe 
            500                 505                 510         


Arg Arg Arg Ser Ala Gly Asn Ser Lys Thr Gly Tyr Ser Glu Lys Ala 
        515                 520                 525             


Leu Glu Glu Leu Gln Ser Arg Lys Gln Thr Leu Asn Val Val Leu Lys 
    530                 535                 540                 


Glu Tyr Gly Leu Asn Asp Lys Gln Ile Pro Ala Arg Ile Leu Asn Tyr 
545                 550                 555                 560 


Trp Leu Lys Ile Val Asp Val Asp Ala Glu His Ser Phe Ser Glu Arg 
                565                 570                 575     


Ile Lys Leu Met Arg Ser Asp Cys Lys Lys Arg Leu Arg Ala Met Glu 
            580                 585                 590         


Lys His Arg Leu Asp Pro Asn Glu Arg Val Pro Lys Val Gly Glu Met 
        595                 600                 605             


Ala Ser Phe Leu Ala Lys Asp Ile Val Ser Met Val Ile Asp Arg Lys 
    610                 615                 620                 


Lys Lys Glu Arg Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Ala Cys 
625                 630                 635                 640 


Leu Ala Phe Tyr Ala Asp Glu Glu Lys Asn Val Leu Phe Gly Gln Ile 
                645                 650                 655     


Val Lys Glu Leu Gly Leu Leu Glu Lys Gly Gly His Pro Phe Leu Ala 
            660                 665                 670         


Asn Val Leu Glu Arg Lys Pro Arg Asn Thr Ala Gln Leu Tyr Thr Asp 
        675                 680                 685             


Tyr Leu Lys Glu Lys Ala Asp Lys Ser Met Arg Lys Arg Leu Ser Lys 
    690                 695                 700                 


Arg Met Ile Glu Gly Pro Asp Thr Ser Trp Ile Cys Arg Thr Phe Tyr 
705                 710                 715                 720 


Arg Lys Glu Arg Cys Asn Gly Lys Ile Met Thr Lys Ile Arg Leu Pro 
                725                 730                 735     


Glu Asp Val Ser Glu Ile Pro Leu Thr Ile Asn Gln Trp Ala Ala Lys 
            740                 745                 750         


Glu Lys Ser Asp Leu Asp Thr Trp Leu Asn Asn Ile Thr Arg Arg Glu 
        755                 760                 765             


Thr Lys Lys Gly Ile Asp Leu Pro Thr Asn Leu Phe Asp Thr Lys Leu 
    770                 775                 780                 


Cys Glu Leu Leu Arg Cys Arg Leu Asp Asp Lys Gly Ile Arg Tyr Asp 
785                 790                 795                 800 


Ala Gly Ser Asn Tyr Asn Glu Leu Leu Lys Leu Trp Trp Gly Leu Val 
                805                 810                 815     


Arg Glu Asp Ser Val Gln Glu Phe Tyr Ala Thr Glu Arg Glu Tyr Val 
            820                 825                 830         


Val Tyr Gly Glu Asn Ile Asn Phe Ile Ala Asp Ser Glu Lys Lys Phe 
        835                 840                 845             


Gln Asn Tyr Tyr Ser Asp Ala Phe His Lys Val Ala Glu Gln His Lys 
    850                 855                 860                 


Leu Asp Ala Val Lys Gln Ser Pro Ala Gln Leu Glu Arg Val Phe Lys 
865                 870                 875                 880 


His Ala Val Ala Gly Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu 
                885                 890                 895     


Asp Arg Leu Met Leu Leu Met Val Glu Gln Leu Met Gly Arg Met Asp 
            900                 905                 910         


Gly Leu Lys Leu Ser Gln Val Gln Ser Leu Leu Asp Glu Glu Ile Pro 
        915                 920                 925             


Ala Glu Leu Gln Leu Lys Tyr Asp Ala Val Gly Ser Val Val Thr Asp 
    930                 935                 940                 


Asp Ser Ala Val Ser Val Met Thr Arg Tyr Val Val Ala Thr Cys Lys 
945                 950                 955                 960 


Arg Lys Asp His Thr Lys Leu Arg Lys Tyr Arg Tyr Asp Arg Arg Leu 
                965                 970                 975     


Ala Gly Leu Phe Thr Tyr His Pro Gly Glu Val Val Lys Gln Glu Trp 
            980                 985                 990         


Leu Lys Glu Gln Leu Ala Ala Tyr  Asn Lys Ala Lys Leu  Asp Val Phe 
        995                 1000                 1005             


Asp Met  Val Phe Lys Leu Glu  Glu Gln Ile Thr Leu  Lys Asp Val 
    1010                 1015                 1020             


Asp Gly  Val Glu Ala Leu Phe  Leu Asp Glu Gln Gln  Arg Pro Lys 
    1025                 1030                 1035             


Ser Gly  Asn Ile Gln His Trp  Pro Tyr Leu Lys Trp  Leu Glu Met 
    1040                 1045                 1050             


Lys Gly  Ile Ile Asn Asp Lys  Glu Ser His Phe Leu  Ser Ser Val 
    1055                 1060                 1065             


Arg Asn  Ser Phe Ser His Asn  Lys Phe Pro Glu Gln  Glu Asp Met 
    1070                 1075                 1080             


Pro Lys  Ser Thr Thr Thr Glu  Asn Ser Leu Pro Ile  Ala Ala Gln 
    1085                 1090                 1095             


Ile Ala  Asn Ala Tyr Thr Gln  Lys Val Glu Glu Ile  Met Glu Lys 
    1100                 1105                 1110             


Val Ala  Gly Leu 
    1115         


<210>  2173
<211>  1106
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2173

Met Glu Thr Asn Gln Pro Ile Asn Glu Asn Arg Arg Arg Thr Leu Ser 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Ser Asn His Ile Ala Ala Asp Phe Glu Gln Ser Thr 
        35                  40                  45              


Leu Thr Glu Glu Gly Gln Ile Pro Ala Ser Phe Leu Cys Asn Gln Gly 
    50                  55                  60                  


Ile Lys Lys Leu Asn Trp Asn Arg Val Phe Glu Lys Thr Lys Arg Phe 
65                  70                  75                  80  


Leu Ser Ile Leu Lys Val Phe Asp Val Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Arg Glu Asn Ser Glu Lys Glu Gly Lys Asp Phe Ala Ala Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Thr Val Phe Gly Glu Leu Gln Asp Phe Arg Asn Asp Tyr 
        115                 120                 125             


Thr His Tyr Tyr Ser Thr Glu Lys Ala Asp Thr Arg Lys Leu Thr Val 
    130                 135                 140                 


Ser Val Glu Leu Ala Asp Phe Leu Lys Leu Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Leu Asn Asp Val Leu Thr Asp Ala Asp Tyr 
                165                 170                 175     


Glu Leu Val Glu Gly Lys Gln Val Val Thr Ala Asp Asn Val Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Met Phe Leu Glu Arg Glu His 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asn Leu Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Asp 
            260                 265                 270         


Val Ile Thr Glu Lys Glu Arg Leu Gln Phe Arg Pro Glu Leu Asp Glu 
        275                 280                 285             


Gln Gly Ile Glu Asn Leu Leu Ala Asn Ser Met Asn Asp Asp Glu Arg 
    290                 295                 300                 


Glu Ser Ile Leu Asp Gly Ile Asp Tyr Asp Lys Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg His Thr Asn Arg Phe Pro Tyr Tyr Ala Met Arg 
                325                 330                 335     


Phe Ile Asp Glu Lys Asn Ile Phe Ser Lys Leu Trp Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Phe Glu Val Asp Lys Tyr Ser Lys Gln Leu Ala Gly Glu 
        355                 360                 365             


Gln Thr Glu Arg Val Val Leu Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asp Pro Val Val Ile Glu His Lys Ile Asp Asn Gln 
385                 390                 395                 400 


Lys Arg Thr Asp Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Asp Ile Ala His Leu Ile 
            420                 425                 430         


Pro Lys Ser Lys Pro Asp Thr Lys Val Gly Asn Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Asp Tyr Leu Gln Lys Gly Lys Ala Glu Gln Leu Ile Thr Asp Phe 
465                 470                 475                 480 


Ile Lys Leu Asn Asp Glu Arg Leu Met Asp Ile Arg Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Leu Lys Leu Pro Ala Asp Trp Asn Glu Phe Ala Lys Arg Ser 
            500                 505                 510         


Asp Ser Lys Lys Lys Arg Ala Tyr Ser Gly Ala Ala Leu Lys Tyr Leu 
        515                 520                 525             


His Gln Arg Lys Ala Thr Leu Asn Glu Val Leu Ile Ala Tyr Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Asn Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ala Arg Leu Lys Val Ile Glu Lys His Lys Val 
            580                 585                 590         


Asp Lys Ser Val Lys Thr Pro Lys Leu Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Met Val Ser Lys Glu Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Ala Asp Ala Glu Lys Lys Ala Leu Phe Ile His Ile Ile Thr His Glu 
                645                 650                 655     


Leu Lys Leu Phe Glu Asn Gly Gly His Pro Phe Leu Gln Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Glu Ala Tyr Leu Lys 
        675                 680                 685             


Glu Lys Ala Asn Lys Gln Val Pro Lys Thr Asn Arg Thr Asn Gln Val 
    690                 695                 700                 


Asp Glu Ser Trp Met Met Lys Gln Phe Tyr Ile Lys Glu Arg Lys Glu 
705                 710                 715                 720 


Glu Ile Gly Lys Gln Leu Thr Val Val Lys Leu Pro Ala Asn Arg Asn 
                725                 730                 735     


Asn Ile Pro Tyr Thr Ile Arg Gln Trp Asp Glu Lys Glu Asn Tyr Asn 
            740                 745                 750         


Leu Asn Lys Trp Leu Glu His Val Thr Val Gly Lys Val Lys Gly Asp 
        755                 760                 765             


Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe Asp Glu Thr Leu 
    770                 775                 780                 


Ser Asp Leu Leu Arg Ser Glu Leu Asp Ala Arg Ala Val Asn Tyr Asn 
785                 790                 795                 800 


Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Leu Trp Trp Lys Ser Arg 
                805                 810                 815     


Asn Asp Gly Thr Gln Ser Tyr Tyr Glu Ser Glu Arg Glu Tyr Thr Ile 
            820                 825                 830         


Tyr Asp Glu Lys Val Ser Phe Arg Ile Asn Ser Ala Asn His Phe Ala 
        835                 840                 845             


Asp Tyr Tyr Gln Lys Ala Leu Ser Arg Ala Tyr Asn Arg Leu Lys Ala 
    850                 855                 860                 


Glu Arg Glu Thr Ala Arg Arg Thr Asn Leu Arg Leu Pro Pro Ile Glu 
865                 870                 875                 880 


Arg Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile Ala Glu Thr Glu 
                885                 890                 895     


Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Cys Met Ala Val Leu Met 
            900                 905                 910         


Leu Glu Gln Leu Met Asp Asn Thr Asp Asn Leu Lys Leu Ser Thr Ile 
        915                 920                 925             


Glu Thr Leu Leu Asn Asp Thr Thr Arg Ile Lys Gln Asn Ile Leu Asn 
    930                 935                 940                 


Lys Ile Leu Val Ala Glu Arg Lys Gln Lys Asn Tyr Thr Glu Leu Arg 
945                 950                 955                 960 


Lys Tyr Ile His Asp Arg Arg Leu Pro His Leu Phe Glu Tyr Val Ala 
                965                 970                 975     


Ala Asn Glu Ile Gln Leu Glu Trp Leu Gln Glu Glu Leu Arg Ala Tyr 
            980                 985                 990         


Asn Thr Ala Lys Gln Gln Val Phe  Asp Thr Val Phe Ala  Leu Glu Lys 
        995                 1000                 1005             


Lys Ile  Thr Glu Thr Asp Pro  His Gly Leu Lys Ala  Leu Phe Ile 
    1010                 1015                 1020             


Gln Asp  Asn Gly Asn Ala Lys  Thr Gly Asn Ile Glu  His Lys Pro 
    1025                 1030                 1035             


Tyr Val  Gln Trp Leu Asn Asn  Lys Gly Leu Ile Ser  Glu Glu Asp 
    1040                 1045                 1050             


Ser Arg  Phe Met Leu Glu Val  Arg Asn Arg Phe Ser  His Asn Glu 
    1055                 1060                 1065             


Phe Pro  Val Arg Gln Thr Val  Glu Leu Arg Ile Pro  Ala Cys Asn 
    1070                 1075                 1080             


Glu Asn  Lys Ile Ala Leu Gln  Ile Val Thr Lys Tyr  Asp Glu Leu 
    1085                 1090                 1095             


Ile Ala  Gly Ile Ile Ser Arg  Ile 
    1100                 1105     


<210>  2174
<211>  1160
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2174

Met Lys Asn Glu Ile Leu Thr Asn Ser Lys Ser Leu Lys Ser Asn Pro 
1               5                   10                  15      


Asp Tyr Phe Ser Ala Tyr Leu Asn Met Ala Arg His Asn Ala Tyr Leu 
            20                  25                  30          


Ile Leu Ser His Ile Ser Asp Lys Leu Lys Pro Lys Lys Thr Asn Thr 
        35                  40                  45              


Pro Glu Asp Ala Leu His Ser Ala Tyr Ala Leu Glu Val Leu Lys Ser 
    50                  55                  60                  


Ser Lys Glu Pro Asp Ile Thr Ala Lys Ser Ile Lys Met Leu Asn Glu 
65                  70                  75                  80  


His Phe Pro Phe Leu Lys Val Met Phe Asp Thr Asn Ser Ile Thr Glu 
                85                  90                  95      


Lys Ser Lys Gly Ser Lys Gly Ile Tyr Ser Glu Lys Leu Pro Glu Gln 
            100                 105                 110         


Tyr Leu Asp Lys Met Met Leu Leu Leu Asp His Leu Asn Asn Tyr Arg 
        115                 120                 125             


Asn Ser Tyr Thr His Cys Val His Ile Pro Ile Ile Asn Asp Lys Asn 
    130                 135                 140                 


Phe Ile Tyr Cys Leu Asn Asn Ile Phe Asp Ala Ser Val Arg Thr Val 
145                 150                 155                 160 


Lys Asp Arg Phe Glu Phe Ser Glu Asn Asp Val Ser His Leu Arg Arg 
                165                 170                 175     


Tyr Glu Gln Val Phe Asp Pro Glu Thr Lys Lys Arg Lys Ala Ser Arg 
            180                 185                 190         


Lys Lys Asp Phe Lys Tyr Asn Phe Ile Asp Asn Asp Asp Ile Ser Glu 
        195                 200                 205             


Lys Gly Ile Ala Phe Phe Ile Ala Leu Phe Leu Glu Lys Lys His Ala 
    210                 215                 220                 


Phe Glu Phe Leu Lys Lys Leu Ser Asp Phe Lys Asp Ser Arg Thr Lys 
225                 230                 235                 240 


Met Met Gln Ala Thr Leu Glu Ser Tyr Cys Val Tyr His Ile Arg Leu 
                245                 250                 255     


Pro Lys Glu Arg Ile Glu Asn Thr Gln Asn Asp Leu Ser Leu Cys Leu 
            260                 265                 270         


Asp Ile Phe Asn Glu Leu Lys Lys Cys Pro Ser Glu Leu Phe Asp Leu 
        275                 280                 285             


Leu Lys Lys Glu Asp Ala Glu Lys Phe Arg Ile Lys Pro Asp Ile Asn 
    290                 295                 300                 


Asn Leu Asn Asp Glu Asp Ser Gly Asn Ile Val Glu Asn Ser Thr Asp 
305                 310                 315                 320 


Asp Tyr Asn Val Glu Pro Ile Leu Lys Arg Tyr Ser Asn Arg Phe Pro 
                325                 330                 335     


Tyr Leu Ala Met Arg Tyr Ile Asp Glu Lys Lys Val Phe Gln Lys Leu 
            340                 345                 350         


Arg Phe His Val Asp Leu Gly Asn Tyr Tyr Phe Lys Phe Tyr Pro Lys 
        355                 360                 365             


Thr Thr Val Asp Gly Glu Lys Arg Asp Arg Ser Leu Lys Val His Leu 
    370                 375                 380                 


Asn Ser Phe Gly Arg Leu Asp Asp Leu Asn His Ala Arg Leu Val Glu 
385                 390                 395                 400 


Trp Asn Asp Leu Ile Arg Phe His Lys Glu Glu Glu Asp Glu Asn Pro 
                405                 410                 415     


Ile Glu Glu Leu Met Pro Tyr Ile Thr Asp Thr Tyr Pro His Tyr His 
            420                 425                 430         


Leu His Asn Asn Gln Ile Gly Leu Lys Asp Thr Gln Asn Asn Pro Asp 
        435                 440                 445             


Lys Leu Leu Pro Lys Ile Glu Arg Glu Lys Thr Lys Thr Glu Gln Pro 
    450                 455                 460                 


Asp Phe Trp Leu Ser Thr Tyr Glu Leu Pro Ala Leu Leu Phe Tyr Ser 
465                 470                 475                 480 


Tyr Leu Leu Lys Lys Lys Arg Asp Ile Ser Ala Glu Asp Leu Ile Leu 
                485                 490                 495     


Asn Cys Arg Lys Lys Tyr His Thr Leu Phe Lys Leu Ile Ser Glu Gly 
            500                 505                 510         


Asn Gly Pro Glu Ile Lys Glu Cys Gln Val Thr Ile Lys Gln Lys Gly 
        515                 520                 525             


Lys Asn Ile Ser Val Phe Leu Leu Thr Ala His Phe Glu Asp Glu Thr 
    530                 535                 540                 


Gly Lys Ser His Glu Ile Glu Leu Asn Asp Leu Pro Gln Val Phe Gln 
545                 550                 555                 560 


Asn Tyr Leu Thr Asp Lys Gln Leu His Asn Arg Glu Glu Leu Ala Glu 
                565                 570                 575     


Asn Lys Ile Asn Arg Leu Ile Ile Glu Thr Glu Arg Arg Arg Glu Lys 
            580                 585                 590         


Ile Asn Lys Asp Leu Glu Arg Ile Asn Gly Leu Lys Gly Asn Lys Arg 
        595                 600                 605             


Gly Lys Lys Asn Phe Val Glu Ile Lys Ser Gly Met Leu Ala Asp Phe 
    610                 615                 620                 


Leu Ala Lys Asp Thr Ile Arg Leu Gln Pro Ser Ile Asp Ala Ile Gly 
625                 630                 635                 640 


Lys Asp Lys Ile Thr Gly Leu Asn Phe Gln Ile Leu Gln Ser His Leu 
                645                 650                 655     


Ala Phe Tyr Gly Arg Asp Phe Leu Met Leu Lys Asp Ile Phe Arg Gln 
            660                 665                 670         


Cys Lys Leu Val Asp Ala Gln Ile Ser His Pro Phe Leu Tyr Lys Leu 
        675                 680                 685             


Asn Pro Glu Asp His Phe Asp Ile Val Ser Phe Tyr Lys Ala Tyr Leu 
    690                 695                 700                 


Gly Glu Arg Lys Lys Tyr Leu Glu Gln Cys Asn Arg Asn Lys Asp Tyr 
705                 710                 715                 720 


Lys Ser Tyr Tyr Phe Leu Lys Phe Asn Ser Gln Lys Phe Thr Thr Glu 
                725                 730                 735     


Thr Ile Glu Tyr Cys Lys Asp Leu Ala Lys Lys Leu Met Asn Thr His 
            740                 745                 750         


Ser Gln Asp Asn His Pro Ile Asn Leu Pro Arg Gly Met Phe Met Asp 
        755                 760                 765             


Ala Ile Ile Asp Trp Phe Lys Lys His Gly Asp Pro Gln Leu Gln Ala 
    770                 775                 780                 


Ile Ala Lys Thr Glu Arg Val Asn Ala Val Tyr Leu Ile Gln Lys Phe 
785                 790                 795                 800 


Phe Glu Phe Lys Lys Asp Ser Asn Gln Pro Phe Tyr Asp Tyr Pro Arg 
                805                 810                 815     


Ser Tyr Asp Phe Ile Asp Lys Leu Glu Asn Phe Asn Asn Met Arg Cys 
            820                 825                 830         


Gly Arg Pro Leu Leu Leu Gln Arg Lys Tyr Tyr Ser Ile Gln Gln Leu 
        835                 840                 845             


Ala Asp Lys Ile Asp Asp Val Lys Thr Arg Ile Thr Lys Leu Pro Glu 
    850                 855                 860                 


Ser Glu Pro Asn Asp Ser His Pro Arg Lys Arg Met Leu Ala Thr Leu 
865                 870                 875                 880 


Ser Asp Tyr Lys Gln Asn Glu Lys Leu Leu Arg Leu Tyr Lys Thr Gln 
                885                 890                 895     


Asp Arg Ile Leu Phe Leu Val Ala Ser Asp Ile Leu Phe Ala Gln Lys 
            900                 905                 910         


Pro Gln Gly Leu Glu Glu Asn Asp Leu Lys Leu Ser Asn Val Lys Pro 
        915                 920                 925             


Lys Pro Glu Asn Asp Ser Asp Glu Asp Leu Leu Ser Ser Gln Leu Pro 
    930                 935                 940                 


Phe Arg Phe Pro Tyr Gln Tyr Trp Asp Val Thr Ser Lys Gly Glu Ile 
945                 950                 955                 960 


Asp His Lys Asn Lys Ile Gly Glu Val Ile Ile Phe Gln Lys Lys Leu 
                965                 970                 975     


Lys Leu Lys Asn Tyr Gly Asp Phe Ile Arg Tyr Thr Lys Asp Arg Arg 
            980                 985                 990         


Leu Asn Asn Leu Phe His Trp Thr  Gly Asp Ile Glu Leu  Glu Met Pro 
        995                 1000                 1005             


Val Leu  Gln Lys Glu Leu Glu  Arg Tyr Glu Glu Ala  Arg Leu Thr 
    1010                 1015                 1020             


Val Phe  Arg Leu Ile His Asp  Phe Glu Lys Ala Met  Tyr Glu Lys 
    1025                 1030                 1035             


His His  Leu Phe Phe Asp Glu  Leu Leu Lys Thr Asn  Lys Leu Lys 
    1040                 1045                 1050             


Lys Glu  Asn Glu Asn Glu Asn  Ser Tyr Ile Asn His  Glu Glu Met 
    1055                 1060                 1065             


Leu Glu  Lys Phe Phe Ser Asp  Tyr Pro Glu Leu Ile  His Tyr Glu 
    1070                 1075                 1080             


Asp Val  Met Leu Thr Ile Arg  Asn Cys Phe Ser His  Asn Gln Tyr 
    1085                 1090                 1095             


Pro Val  Lys Cys Ala Phe Asp  Asn Ile Asp Ser Ile  Gly Leu Phe 
    1100                 1105                 1110             


Glu Gly  Cys Pro Asp Ile Glu  Ser Asp His Asp Asn  Glu Leu Asn 
    1115                 1120                 1125             


Ile Ala  Met Arg Ile Lys Asn  His Ala Ile Ala Thr  Tyr Gly Glu 
    1130                 1135                 1140             


Phe Ile  Lys Ile Leu Thr Asn  Leu Thr Pro Ile His  Asp Ile Asn 
    1145                 1150                 1155             


Val Ser  
    1160 


<210>  2175
<211>  1145
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2175

Met Glu Thr Leu Thr Ile Pro Glu Val Ile Lys Cys Arg Thr Leu Ser 
1               5                   10                  15      


Asp Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Ile Ala Lys Glu Phe Asp Leu Pro Leu 
        35                  40                  45              


Leu Ala Glu Glu Gly His Leu Lys Asn Ser Phe Leu Cys Lys Lys Glu 
    50                  55                  60                  


His Asn Lys Val Asn Trp Asn His Val Tyr Ser Arg Thr Lys Arg Phe 
65                  70                  75                  80  


Leu Ala Val Leu Lys Val Phe Asp Ala Glu Thr Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Lys Thr Ile Asn Trp Glu Gly Lys Asp Phe Ala Ser Met Ser Asp 
            100                 105                 110         


Ile Leu Lys Ile Val Phe Gly Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Thr Ile Arg Lys Thr Ala Val 
    130                 135                 140                 


Ser Ala Glu Met Ala Leu Phe Leu Thr Thr Asn Phe Arg Arg Ala Ile 
145                 150                 155                 160 


Glu Tyr Thr Lys Glu Arg Phe Lys Gly Val Leu Asn Asp Glu Asp Tyr 
                165                 170                 175     


Gln Leu Val Ala Ser Lys Lys Val Leu Glu Ala Asn Ser Thr Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Arg Phe Ile Gly Ile Ile Thr Gly Leu Lys Gly Thr Gln Asn 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro His Asp Arg Phe Gln Ser Asp Asn Pro Arg Gln Ala Phe Ser 
                245                 250                 255     


Leu Asp Leu Ile Asn Glu Leu Asn Arg Cys Pro Lys Val Leu Tyr Asn 
            260                 265                 270         


Ala Ile Thr Glu Glu Gly Lys Gln Lys Leu Arg Ser Ile Pro Gly Glu 
        275                 280                 285             


Leu Glu Asn Lys Asn Leu His Asp Asn Asn Thr Lys Lys Glu Ala Lys 
    290                 295                 300                 


Ile Glu Ala Glu Ala Tyr Glu Leu Tyr Ile Glu Ser Leu Thr Arg Gln 
305                 310                 315                 320 


Ile Arg Tyr Ser Asn Arg Phe Pro Asp Phe Ala Leu Lys Phe Ile Asp 
                325                 330                 335     


Glu Thr Asp Ile Phe Ser Glu Phe Arg Phe Gln Ile Asp Leu Gly Lys 
            340                 345                 350         


Leu Leu Val Asp Glu Tyr Leu Lys Phe Phe Asn Gly Glu His Val Gln 
        355                 360                 365             


Arg Arg Ile Val Glu Asn Ala Lys Ala Phe Gly Lys Leu Ile Asp Phe 
    370                 375                 380                 


Asn Asp Glu Ala Lys Val Met Thr Arg Ile Gly Asn Gly His Phe Ser 
385                 390                 395                 400 


Lys Arg Phe Glu Gln Phe Ala Pro Phe Tyr Asn Thr Glu Asp Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Arg His His Val Thr Ala Lys Leu Gly Pro Asp Ser 
            420                 425                 430         


Lys Gly Glu Pro Glu Lys Lys Leu Leu Gln Pro Leu Pro Glu Ala Phe 
        435                 440                 445             


Leu Ser Leu His Glu Leu Pro Lys Val Ile Leu Leu Asp Tyr Leu Gln 
    450                 455                 460                 


Lys Gly Glu Pro Glu Lys Leu Ile Asn Asp Phe Ile Leu Ile Asn Asn 
465                 470                 475                 480 


Ser Lys Leu Met Asn Met Ser Phe Ile Glu Ala Val Lys Thr Gln Leu 
                485                 490                 495     


Pro Pro Glu Trp Asp Glu Phe Gln Arg Arg Thr Gly Ser Lys Asn Glu 
            500                 505                 510         


Met Pro Tyr Asn Glu Lys Thr Leu Ala Tyr Leu Leu Gln Arg Lys Gln 
        515                 520                 525             


Ile Leu Asn Lys Ile Leu Ala Glu Phe Gln Leu Asn Asp Lys Gln Ile 
    530                 535                 540                 


Pro Gly Arg Ile Leu Asp Tyr Trp Leu Asn Ile Ala Asp Val Glu Glu 
545                 550                 555                 560 


Glu Arg Ala Val Ser Asp Arg Ile Lys Ser Ile Lys Arg Asp Cys Met 
                565                 570                 575     


Ser Arg Leu Arg Ala Leu Gly Lys Phe Lys Ile Asp Arg Asn Arg Asn 
            580                 585                 590         


Lys Ile Pro Lys Ile Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile 
        595                 600                 605             


Val Asp Met Val Val Ser Glu Gly Lys Lys His Lys Ile Thr Ser Phe 
    610                 615                 620                 


Tyr Tyr Glu Lys Met Gln Asp Cys Leu Ser Leu Phe Ala Asp Pro Leu 
625                 630                 635                 640 


Lys Arg Gln Leu Phe Ile His Ile Ile Thr Asn Glu Leu Arg Leu Asn 
                645                 650                 655     


Asp Ser Gly Gly His Pro Phe Leu Phe Lys Leu Asn Met Arg Gln Ile 
            660                 665                 670         


Asn Cys Thr Ser Asp Phe Tyr Glu Ile Tyr Leu Gln Glu Lys Gly His 
        675                 680                 685             


Lys Met Val Pro Glu Lys Asn Leu Lys Thr Gly Lys Val Val Asn Thr 
    690                 695                 700                 


Asp His Ser Trp Met Ala Leu Thr Phe Tyr Lys Leu Glu Phe Asn Asp 
705                 710                 715                 720 


Lys Val Asp Lys Leu Met Thr Val Val Lys Leu Pro Leu Asn Lys Leu 
                725                 730                 735     


Asn Leu Pro Phe Thr Leu Arg Gln Leu Asn Ala Lys Thr Thr Tyr Thr 
            740                 745                 750         


Leu Glu Gln Trp Leu Lys Asn Leu Thr Leu Gly Lys Lys Pro Asp Asp 
        755                 760                 765             


Gly Lys His Pro Val Asn Leu Pro Thr Asn Leu Phe Asp Glu Lys Leu 
    770                 775                 780                 


Ser Asp Leu Leu Arg Gln Asp Leu Asp Asn Asn Lys Ile Ala Tyr Arg 
785                 790                 795                 800 


Pro Tyr Ala Asn Trp Asn Glu Leu Phe Lys Ile Trp Trp Ile Ser Arg 
                805                 810                 815     


Asn Asp Ser Leu Gln Arg Phe Tyr Asn Ala Glu Arg Glu Tyr His Ile 
            820                 825                 830         


Phe Asn Glu Lys Val Asn Phe Tyr Pro Asn Arg Lys Glu Asn Phe Ala 
        835                 840                 845             


Asp Tyr Tyr Gln His Ala Val Lys Val Ala Phe Gln Lys Lys Arg Asn 
    850                 855                 860                 


Glu Arg Ile Ile Glu Gln Arg Ile Asn Lys Tyr Leu Pro Asp Ile Leu 
865                 870                 875                 880 


Phe Glu Gln Val Glu Lys Thr Phe Lys His Thr Ile Ala Glu Thr Glu 
                885                 890                 895     


Lys Glu Ile Arg Ile Leu Gln Glu Glu Asp Arg Ile Met Leu Leu Met 
            900                 905                 910         


Leu Glu Gly Leu Met Glu Asp Gly Asn Lys Gln Gln Leu Lys Leu Ser 
        915                 920                 925             


Glu Ile Lys Thr Leu Gln Asn Ala Thr Ile Asn Ile Arg Gln Leu Val 
    930                 935                 940                 


Pro Gly Lys Leu Ser Phe Asp Asp Ser Gly Glu Ala Ile Lys Asp Ser 
945                 950                 955                 960 


Thr Asn Pro Glu Ile Val Arg Thr Val Ser Val Ser Ile Lys Arg Ile 
                965                 970                 975     


Glu Tyr Asn Leu Leu Pro Lys Tyr Val Ala Asp Gly Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Pro Asp Glu  Glu Ile Gln Met Glu  Arg Leu Lys 
        995                 1000                 1005             


Thr Glu  Phe Asp Thr Tyr Asn  Lys Val Arg Gln Val  Val Leu Asp 
    1010                 1015                 1020             


Leu Ser  Phe Lys Leu Glu Lys  Met Ile Ile Glu Lys  Gly His Lys 
    1025                 1030                 1035             


Asp Arg  Ile Asn Gln Leu Cys  Thr Gly Ala Thr Gly  Glu Leu Leu 
    1040                 1045                 1050             


Thr Gly  Asn Ile Cys His His  Thr Tyr Leu Thr Trp  Leu Lys Asp 
    1055                 1060                 1065             


Lys Glu  Met Ile Asp Asn Glu  Thr Phe Ile Phe Met  Asn Met Val 
    1070                 1075                 1080             


Gln His  Cys Phe Ser His Asn  Gln Tyr Pro Gln Lys  Lys Thr Met 
    1085                 1090                 1095             


Glu Arg  Ile Ile Asn His Trp  Glu Pro Asp Arg Phe  Ala Leu Thr 
    1100                 1105                 1110             


Ile Ala  Ala Thr Tyr Asn Gln  Lys Ile Ala Gly Ile  Leu Glu Asp 
    1115                 1120                 1125             


Ile Gly  Thr Phe Pro Phe Ile  Arg Ser Arg Lys Thr  Met Pro Asp 
    1130                 1135                 1140             


Val Val  
    1145 


<210>  2176
<211>  1393
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (504)..(617)
<223>  Xaa can be any naturally occurring amino acid

<400>  2176

Met Ala Asn Asn Gln Phe Ile Leu Val Pro Val Asp Tyr Ser Arg Pro 
1               5                   10                  15      


Tyr Asp Glu Gln Pro Glu Cys Lys Arg His Val Ile Gly Ala Tyr Ala 
            20                  25                  30          


Asn Leu Ala Arg His Asn Met Thr Val Thr Ile Asn Ala Ile Met Gln 
        35                  40                  45              


Ala Ile Gly Leu Glu Leu Phe Asn Glu Asn Asn Ile Asp Asn Ala Phe 
    50                  55                  60                  


Asn Ser Ser His Arg Lys Ile Leu Ser Gln Leu Asp Asn Ile Gln Lys 
65                  70                  75                  80  


Val Asn Leu Gln Lys Arg Leu Tyr Arg His Phe Pro Phe Phe Lys Arg 
                85                  90                  95      


Met Lys Leu Glu Asp Glu Asn Lys Lys Ser Val Gln Leu Asn Thr Leu 
            100                 105                 110         


Leu Glu Val Met Ser Asp Phe Thr Ser Cys Met Ala Met Ile Arg Asn 
        115                 120                 125             


Phe Tyr Thr His Tyr His Pro Tyr Asn Ser Pro Ala Glu Leu Ala Asn 
    130                 135                 140                 


Gln Leu Glu Leu Lys Lys Gln Met Gly Lys Arg Leu Gln Tyr Leu Phe 
145                 150                 155                 160 


Glu Asn Thr Ser Gln Met Phe Lys Ser Asn Glu Asn Leu Asp His Glu 
                165                 170                 175     


Ser Asn Glu Val Phe Ala Ala Leu Arg Ile Pro Glu Asp Tyr Ile Glu 
            180                 185                 190         


Glu Phe Met Pro Gly Asp Lys Asp Tyr Gln Lys Phe Glu Thr Leu Leu 
        195                 200                 205             


Lys Asp Pro Lys Val Ser Arg Phe Lys Lys Gln Gly Leu Lys Leu Asp 
    210                 215                 220                 


Met Lys Thr Gln Lys Ile Thr Lys Lys Thr Val Arg Tyr Ile Arg Asn 
225                 230                 235                 240 


Pro Glu Tyr Gln Ala Tyr Met Met Asp Asp Glu Lys Gly Met Ser Asp 
                245                 250                 255     


Ile Ala Ile Ile Tyr Phe Leu Cys Leu Phe Leu Glu Lys Lys Val Ser 
            260                 265                 270         


Phe Glu Leu Met Glu Glu Val Gly Leu Thr Glu Gln Val Lys Phe Asn 
        275                 280                 285             


Gly Glu Asn Ala Asp Gln Gln Leu Leu Phe Val Lys Glu Ile Leu Cys 
    290                 295                 300                 


Met Asn Arg Ile Arg Met Thr Lys Thr Lys Leu Asp Ser Glu Met Thr 
305                 310                 315                 320 


Asp Thr Ala Leu Ala Leu Asp Met Ile Asn Glu Leu Arg Lys Cys Pro 
                325                 330                 335     


Lys Pro Leu Tyr Glu Val Phe Cys Lys Glu Ala Arg Asp Glu Phe Lys 
            340                 345                 350         


Asp Ala Ser Thr Val Gln Trp Glu Lys Glu Asn Arg Thr Glu Ala Val 
        355                 360                 365             


Asn Thr Glu Glu Asn Thr Asp Asn Glu Asp Glu Met Ala Ala Glu Lys 
    370                 375                 380                 


Asp Thr Pro Arg Ser Thr Phe Val Arg Trp Glu Asp Arg Phe Pro Gln 
385                 390                 395                 400 


Met Ala Leu Arg Tyr Ile Asp Tyr Gln Gly Leu Phe Asn Asp Ile Arg 
                405                 410                 415     


Phe Gln Leu Asn Leu Gly Lys Tyr Arg Phe Ala Phe Tyr Gln His Asp 
            420                 425                 430         


Lys Thr Tyr Ser Val Asp Asn Glu Glu Arg Leu Arg Ile Leu Gln Lys 
        435                 440                 445             


Glu Leu His Gly Phe Gly Arg Ile Gln Glu Val Gln Ala Lys Lys Asn 
    450                 455                 460                 


Glu Lys Trp Ala Asp Leu Tyr Asp Lys Lys Tyr Val Glu Glu Gly Leu 
465                 470                 475                 480 


Thr Lys Lys Lys Pro Asp Glu Ala Gly Gln Ala Pro Tyr Val Thr Glu 
                485                 490                 495     


Gln Tyr Ala Gln Tyr Ala Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            500                 505                 510         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        515                 520                 525             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    530                 535                 540                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
545                 550                 555                 560 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                565                 570                 575     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            580                 585                 590         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        595                 600                 605             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Phe Ile Pro Tyr Leu Pro Thr 
    610                 615                 620                 


Lys Pro Leu Gln Glu Gly Lys Gln Thr Asn Gln Ser Glu Pro Leu Leu 
625                 630                 635                 640 


Pro Pro Gln Ala Leu Leu Ser Leu Tyr Glu Leu Pro Ser Leu Leu Phe 
                645                 650                 655     


Tyr Gln Tyr Leu Leu Ala Lys Gln Gly Lys Asn Lys Phe Glu Ala Glu 
            660                 665                 670         


Asn Met Ile Lys Lys Tyr Tyr His Cys Leu Tyr Arg Phe Phe Gln Asp 
        675                 680                 685             


Ile Ser Ser Gly Thr Leu Lys Pro Val Ala Gly Lys Asp Glu Lys Asp 
    690                 695                 700                 


Asn Leu Glu Lys Leu Ala Lys Val Leu Ser Ala Glu Pro Tyr Cys Leu 
705                 710                 715                 720 


Arg Leu Thr Asp Ile Pro Asp Lys Leu Lys Lys Tyr Leu Leu Gly Ile 
                725                 730                 735     


Ser Val Asp Asn Gly Gln Arg Met Glu Gln Ser Ala Ile Cys Arg Leu 
            740                 745                 750         


Glu Glu Arg Lys Glu Arg Lys Gln Lys Thr Leu Asn Asn Phe Val Asp 
        755                 760                 765             


Lys Lys Lys Lys Ile Gly Ser Lys Glu Asn Lys Phe Asp Arg Met Arg 
    770                 775                 780                 


Ala Thr Ile Lys Thr Gly Ser Leu Gly Gln Leu Leu Ala Arg Asp Ile 
785                 790                 795                 800 


Met Gly Trp Leu Thr Asp Asp Thr Lys Thr Arg Met Lys Leu Thr Gly 
                805                 810                 815     


Gln Asn Phe Val Ala Met Gln Thr Ala Leu Thr Leu Leu Gly Gln Ser 
            820                 825                 830         


Phe Gly Gly Gly Arg Asp His Glu Val Asn Cys Thr Lys Leu Arg Glu 
        835                 840                 845             


Ile Phe Leu Lys Ala Asn Ile Leu Pro Glu Asn Asp Asp Asp Tyr Asp 
    850                 855                 860                 


Ala Asp Leu His His Pro Phe Leu Leu Asn Val Leu Asp Glu Glu Pro 
865                 870                 875                 880 


Ser Ser Val Glu Glu Phe Tyr Glu Ile Tyr Leu Glu Glu Glu Leu Asn 
                885                 890                 895     


His Ile Asp Tyr Met Ile Ser Phe Leu Lys Lys His Lys Ala Lys Gly 
            900                 905                 910         


Thr Ala Leu Tyr Ile Pro Phe Met His Ala Asn Arg Ser Arg Trp Lys 
        915                 920                 925             


Asn Ala Asp Glu Asp Ala Met Lys Lys Leu Ala Thr Arg Tyr Leu Glu 
    930                 935                 940                 


Gln Pro Leu Gln Leu Pro Asn Gly Ile Phe Thr Glu Ser Ile Phe Lys 
945                 950                 955                 960 


Leu Leu Met Glu Ile Asp Asn Pro Asn Leu Arg Lys Glu Leu Val Gln 
                965                 970                 975     


Ala Gln Asn Pro Ile Ala Asp Lys Asn Leu Ala Asn Asn Val Ser Tyr 
            980                 985                 990         


Leu Ile Lys Ile Tyr Phe Lys Asn  Val Glu Arg Asp His  Ser Gln Pro 
        995                 1000                 1005             


Phe Tyr  Asn Thr Thr Ala Ile  Asp Gly Glu Pro Ser  Pro Tyr Arg 
    1010                 1015                 1020             


His Val  Tyr Arg Ile Phe Lys  Lys Leu Tyr Gly Gln  Gln Ile Leu 
    1025                 1030                 1035             


His Thr  Asn Gln Thr Thr Thr  Pro Ala Phe Thr Ile  Glu Glu Ile 
    1040                 1045                 1050             


Lys Gly  Leu Arg Lys Gln Ala  Leu Thr Asp Ile Ala  Lys Tyr Val 
    1055                 1060                 1065             


Glu Lys  Asp Ile Ser Asp Trp  Lys Glu Lys Lys Gln  Phe Lys Phe 
    1070                 1075                 1080             


Glu Leu  Lys Leu Lys Lys Lys  Leu Lys Lys Glu Asn  Asp Arg Arg 
    1085                 1090                 1095             


Tyr Lys  Asn His Glu Arg Gln  Leu Asn Val Tyr Glu  Glu Val Asn 
    1100                 1105                 1110             


Lys Ala  Val Gln Gln Glu Ile  Asn Thr Met Ser Ala  Thr Thr Thr 
    1115                 1120                 1125             


Ala Lys  Leu Leu Arg Gln Leu  Lys Lys Val Tyr Asp  Asn Glu Arg 
    1130                 1135                 1140             


Ile Ile  Arg Arg Phe Lys Thr  Gln Asp Met Leu Met  Leu Ile Met 
    1145                 1150                 1155             


Ala Arg  Glu Ile Leu Lys Ala  Lys Ser Gln Asp Lys  Asp Phe Thr 
    1160                 1165                 1170             


Lys Asp  Phe Cys Leu Lys Tyr  Val Met Thr Gly Ser  Leu Leu Asp 
    1175                 1180                 1185             


Lys Pro  Ile Asp Phe Asp Trp  Ser Val Asn Ile Glu  Lys Lys Lys 
    1190                 1195                 1200             


Lys Asn  Glu Glu Gly Lys Ile  Glu Lys Glu Ile Ile  Arg Lys Thr 
    1205                 1210                 1215             


Ile Arg  Gln Glu Gly Met Lys  Met Lys Asn Tyr Gly  Gln Phe Tyr 
    1220                 1225                 1230             


Lys Phe  Ala Ser Asp His Gln  Arg Leu Glu Ser Leu  Leu Ser Arg 
    1235                 1240                 1245             


Leu Pro  Asp Glu Leu Phe Leu  Arg Ala Glu Ile Glu  Asn Glu Leu 
    1250                 1255                 1260             


Ser Tyr  Tyr Asp Thr Asn Arg  Ser Glu Val Phe Arg  Gln Val Tyr 
    1265                 1270                 1275             


Ile Ile  Glu Ser Glu Ala Tyr  Lys Leu Lys Pro Glu  Leu Glu Asn 
    1280                 1285                 1290             


Asn Ala  Asn Ala Asn Glu Glu  Trp Phe Tyr Tyr Val  Asp Lys Lys 
    1295                 1300                 1305             


Gly Lys  Lys His Pro Lys Arg  Asn Asn Phe Leu Ser  Leu Leu Glu 
    1310                 1315                 1320             


Ile Leu  Ala Ala Gly Lys Asp  Gly Ile Leu Asp Glu  Asp Glu Lys 
    1325                 1330                 1335             


Arg Ser  Leu Gln Ser Thr Arg  Asn Ala Phe Gly His  Asn Thr Tyr 
    1340                 1345                 1350             


Asp Val  Asp Leu Pro Thr Val  Phe Glu Gly Lys Glu  Glu Lys Met 
    1355                 1360                 1365             


Lys Ile  Pro Glu Val Ala Asn  Gly Ile Lys Asp Lys  Ile Glu Glu 
    1370                 1375                 1380             


Gln Thr  Ile Glu Leu Lys Glu  Lys Met Lys 
    1385                 1390             


<210>  2177
<211>  1175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2177

Met Thr Glu Gln Asn Glu Arg Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Ala His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Asn Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Cys Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Gly Lys Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Thr Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Ile Asp Ile Leu Ser Asp Glu Glu Asp Thr Asp Gly Thr 
                325                 330                 335     


Lys Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Ala Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Leu Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Glu Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Asp Glu Ile Asn Thr Arg Asp 
    530                 535                 540                 


Glu Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Ile Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Ser Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Gly Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Tyr Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Asp Leu Glu Ala Trp Ser His Ser Ala Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Ala Gly Ile Glu Asn Ala Ser Arg Glu Asn 
    850                 855                 860                 


Lys Lys Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Glu Thr 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Lys Ala Asp Lys Ile Asn Ile Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Ala Lys Glu His Pro Tyr Leu Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asp Ile Arg Thr 
945                 950                 955                 960 


Glu Val Gln Glu Gln Gly Ser Leu Asn Val Leu Asn Arg Val Lys Pro 
                965                 970                 975     


Met Arg Leu Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val 
            980                 985                 990         


His Lys Glu Gln Ala Pro Leu Ala  Thr Val Tyr Ile Glu  Glu Arg Asp 
        995                 1000                 1005             


Thr Lys  Leu Leu Lys Gln Gly  Asn Phe Lys Ser Phe  Val Lys Asp 
    1010                 1015                 1020             


Arg Arg  Leu Asn Gly Leu Phe  Ser Phe Val Asn Thr  Gly Gly Leu 
    1025                 1030                 1035             


Ala Met  Glu Gln Tyr Pro Ile  Ser Lys Leu Arg Val  Glu Tyr Glu 
    1040                 1045                 1050             


Leu Ala  Lys Tyr Gln Thr Ala  Arg Val Cys Ala Phe  Glu Gln Thr 
    1055                 1060                 1065             


Leu Glu  Leu Glu Glu Ser Leu  Leu Thr Arg Tyr Pro  His Leu Pro 
    1070                 1075                 1080             


Asp Lys  Asn Phe Arg Lys Met  Leu Glu Ser Trp Ser  Asp Pro Leu 
    1085                 1090                 1095             


Leu Asp  Lys Trp Pro Asp Leu  His Arg Lys Val Arg  Leu Leu Ile 
    1100                 1105                 1110             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1115                 1120                 1125             


Glu Ala  Val Phe Ser Ser Ile  Arg Lys Tyr Asp Pro  Ser Ser Pro 
    1130                 1135                 1140             


Asp Ala  Ile Glu Glu Arg Met  Gly Leu Asn Ile Ala  His Arg Leu 
    1145                 1150                 1155             


Ser Glu  Glu Val Lys Gln Ala  Lys Glu Thr Val Glu  Arg Ile Ile 
    1160                 1165                 1170             


Gln Ala  
    1175 


<210>  2178
<211>  1324
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2178

Met Gly Lys Glu Asn Lys Gly Asn Asn Ala Pro Lys Thr Gln Asn Lys 
1               5                   10                  15      


Thr Ala Asn Asn Ser Gln Gln Gln Lys Lys Val Arg Arg Leu Gln Lys 
            20                  25                  30          


Thr Ser Phe Arg Ile Ser Leu Thr Gly Lys His Val Phe Gly Ala Tyr 
        35                  40                  45              


Phe Asn Met Ala Arg Thr Asn Phe Ile Lys Thr Ile Asn Tyr Ile Leu 
    50                  55                  60                  


Pro Ile Ala Gly Val Arg Gly Asn Tyr Ser Glu Asn Gln Ile Asn Lys 
65                  70                  75                  80  


Met Leu Arg Ala Leu Phe Leu Ile Gln Ala Gly Arg Asn Gly Glu Leu 
                85                  90                  95      


Thr Thr Glu Gln Lys Gln Trp Glu Lys Lys Leu Arg Leu Asn Pro Glu 
            100                 105                 110         


Gln Lys Thr Arg Leu Gln Lys Leu Leu Phe Lys His Phe Pro Val Leu 
        115                 120                 125             


Ser Pro Met Met Ala Asp Val Ala Asp His Lys Ala Tyr Leu Asn Lys 
    130                 135                 140                 


Lys Lys Ser Asn Val Gln Thr Glu Asp Glu Ala Phe Glu Gln Leu Lys 
145                 150                 155                 160 


Gly Ile Ser Leu Ser Asp Cys Leu Glu Ile Ile Cys Leu Met Ala Glu 
                165                 170                 175     


Thr Leu Thr Glu Cys Arg Asn Phe Tyr Thr His Lys Asp Pro Tyr Asn 
            180                 185                 190         


Lys Pro Ser Leu Leu Ala Ala Gln Tyr Gln His Gln Glu Met Ile Ala 
        195                 200                 205             


Lys Lys Leu Asp Lys Val Ile Val Ala Ser Arg Arg Ile Leu Lys Asp 
    210                 215                 220                 


Arg Glu Gly Leu Ser Val Asn Glu Val Glu Phe Leu Thr Gly Ile Asp 
225                 230                 235                 240 


His Leu His Gln Glu Val Val Lys Asp Glu Phe Gly Asn Val Lys Lys 
                245                 250                 255     


Lys Asp Gly Lys Val Met Lys Thr Phe Val Glu Tyr Asp Asp Phe Tyr 
            260                 265                 270         


Phe Lys Ile Ser Gly Lys Arg Leu Val Lys Gly Phe Thr Val Thr Val 
        275                 280                 285             


Lys Asp Asp Lys Pro Val Asn Val Asp Thr Met Leu Pro Ala Leu Ser 
    290                 295                 300                 


Asp Phe Gly Leu Leu Tyr Phe Cys Val Leu Phe Leu Ser Lys Pro Tyr 
305                 310                 315                 320 


Ala Lys Leu Phe Ile Asp Glu Val Arg Leu Phe Glu Phe Ser Pro Phe 
                325                 330                 335     


Asp Asp Asn Glu Asn Met Ile Met Ser Glu Met Leu Ser Ile Tyr Arg 
            340                 345                 350         


Ile Arg Thr Pro Arg Leu His Lys Ile Asp Ser Arg Asp Asn Lys Ala 
        355                 360                 365             


Thr Leu Ala Met Asp Ile Phe Gly Glu Leu Arg Arg Cys Pro Ile Glu 
    370                 375                 380                 


Leu Tyr Asp Leu Leu Asp Lys Asn Thr Gly Gln Pro Phe Phe His Asp 
385                 390                 395                 400 


Glu Val Lys Arg Pro Asn Ser His Thr Pro Glu Val Ser Lys Arg Leu 
                405                 410                 415     


Arg Tyr Asn Asp Arg Phe Pro Thr Leu Ala Leu Arg Tyr Ile Asp Glu 
            420                 425                 430         


Thr Glu Leu Phe Asn Arg Ile Arg Phe Gln Leu Gln Leu Gly Ala Phe 
        435                 440                 445             


Arg Tyr Lys Phe Tyr Asp Lys Glu Cys Ile Asp Gly Arg Val Arg Val 
    450                 455                 460                 


Arg Arg Ile Gln Lys Asp Ile Asn Gly Tyr Gly Arg Leu Gln Glu Val 
465                 470                 475                 480 


Ala Asp Lys Arg Leu Asp Lys Trp Gly Asp Leu Ile Gln Lys Arg Glu 
                485                 490                 495     


Glu Gln Ser Val Lys Leu Glu His Glu Glu Leu Tyr Leu Asp Leu Asp 
            500                 505                 510         


Gln Phe Gln Gln Asp Thr Ala Asp Ser Thr Pro Tyr Val Thr Asp Arg 
        515                 520                 525             


Arg Pro Ala Tyr Asn Ile His Ala Asn Arg Ile Gly Met Tyr Trp Glu 
    530                 535                 540                 


Asp Ser Gln Asn Pro Lys Leu Phe Glu Val Phe Asp Glu Asn Lys Met 
545                 550                 555                 560 


Tyr Ile Pro Glu Leu Lys Val Ser Glu Asp Met Lys Ala Pro Val Lys 
                565                 570                 575     


Met Pro Glu Pro Arg Cys Ala Leu Ser Ile Tyr Asp Leu Ser Ala Met 
            580                 585                 590         


Leu Phe Tyr Glu Tyr Leu Arg Glu Gln Glu Asp Glu Asn Ile Pro Ser 
        595                 600                 605             


Ala Glu Gln Ile Ile Ile Asp Tyr Glu Ser Asp Tyr Arg Arg Phe Phe 
    610                 615                 620                 


Lys Ala Val Ala Glu Gly Ser Leu Lys Pro Phe Gln Arg Thr Lys Glu 
625                 630                 635                 640 


Phe Arg Glu Tyr Leu Lys Lys Glu Tyr Pro Arg Leu His Leu Ala Asp 
                645                 650                 655     


Ile Pro Glu Lys Leu Gln Ser Tyr Leu Cys Ser His Gly Leu Ser Phe 
            660                 665                 670         


Asn Asn Lys Pro Glu Ser Val Arg Glu Arg Leu Asp Arg Leu Ala Leu 
        675                 680                 685             


Gln His Leu Glu Glu Arg Glu Leu Arg Val His Arg Arg Leu Glu His 
    690                 695                 700                 


Tyr Gln Glu Asp Arg Lys Met Ile Gly Asn Lys Glu Asn Lys Phe Gly 
705                 710                 715                 720 


Lys Lys Ser Phe Ala Asp Val Arg His Gly Ala Leu Ala Arg Tyr Leu 
                725                 730                 735     


Ala Gln Ser Met Met Glu Trp Gln Pro Thr Lys Leu Lys Asp Lys Glu 
            740                 745                 750         


Lys Gly His Asp Lys Leu Thr Gly Leu Asn Tyr Asn Val Leu Thr Ala 
        755                 760                 765             


Tyr Phe Ala Thr Phe Gly Ala Ser His Thr Ile Glu Glu Glu Asn Phe 
    770                 775                 780                 


Thr Pro Arg Thr Leu Glu Gln Val Leu Thr Glu Ala His Ile Leu Gly 
785                 790                 795                 800 


Gly Ser Asn Pro His Pro Phe Ile Asn Lys Val Leu Ala His Gly Asn 
                805                 810                 815     


Arg Asn Ile Glu Glu Leu Tyr Leu His Tyr Leu Asp Glu Glu Leu Lys 
            820                 825                 830         


His Ile Arg Ser Arg Lys Gln Ser Leu Ser Asp Asn Pro Ser Asp Lys 
        835                 840                 845             


Ala Leu Ala Ala Leu Pro Phe Val His Tyr Asp Arg Thr Arg Phe His 
    850                 855                 860                 


Glu Arg Thr Glu Glu Glu Met Lys Ser Leu Ala Ala Arg Tyr Thr Thr 
865                 870                 875                 880 


Ile Gln Leu Pro Asp Gly Leu Phe Thr Pro Tyr Ile Val Lys Leu Leu 
                885                 890                 895     


Gln Glu His Tyr Ala Asp Lys Glu Glu Leu Gln Gln Ala Leu Lys Lys 
            900                 905                 910         


Glu Phe Pro Asp Lys Leu Asn Pro Asn His Asn Ala Ala Tyr Leu Ile 
        915                 920                 925             


Met Leu Phe Tyr Gln Thr Val Leu Asn Asp Asp Ala Gln Pro Phe Tyr 
    930                 935                 940                 


Leu Ser Gly Lys Thr Tyr Thr Arg Gln Leu Glu Glu Gly Lys Thr Glu 
945                 950                 955                 960 


Ser Phe Ser Phe Lys Arg Ala Tyr Glu Leu Phe Ser Val Leu Arg Gly 
                965                 970                 975     


Ser Lys Lys Asn Thr Phe Pro Tyr Glu Leu Ile Pro Leu Phe Leu Thr 
            980                 985                 990         


Cys Asp Glu Ile Gln Gln Asn Leu  Ser Ala Lys Leu Leu  Asp Ala Glu 
        995                 1000                 1005             


Gly Asn  Pro Ile Pro Glu Ala  Gly Lys Arg Gly Lys  Pro Ala Thr 
    1010                 1015                 1020             


Asp Ser  Gln Gly Asn Thr Ile  Trp Lys Arg Arg Ile  Lys Gln Gln 
    1025                 1030                 1035             


Ile Phe  Asp Tyr Val Glu Lys  Gln Ser Asp Arg Asp  Leu Lys Ile 
    1040                 1045                 1050             


Ser Met  Asn Gln Ser Trp Lys  Gln Lys Glu Glu Glu  Arg Ala Ala 
    1055                 1060                 1065             


Lys Arg  Glu Ala Leu Tyr Ser  Arg Leu Thr Arg Gln  Ile Asn Glu 
    1070                 1075                 1080             


Ile Lys  Asn Ser Glu Arg Thr  Leu Arg Arg Tyr Lys  Thr Gln Asp 
    1085                 1090                 1095             


Met Val  Leu Phe Leu Leu Ala  Lys Glu Met Phe Ala  Asn Ile Ile 
    1100                 1105                 1110             


Cys Glu  Gln Gly Asn Glu Val  Asn Ser Lys Gln Met  Arg Leu Ser 
    1115                 1120                 1125             


Lys Val  Cys Asn Gln Ser Phe  Leu Arg Gln Thr Leu  Thr Phe Arg 
    1130                 1135                 1140             


Val Pro  Val Ala Val Gly Glu  Lys Thr Ile Tyr Val  Glu Gln Glu 
    1145                 1150                 1155             


Asn Met  Ser Leu Lys Asn Tyr  Gly Glu Phe Tyr Arg  Phe Leu Thr 
    1160                 1165                 1170             


Asp Asp  Arg Leu Met Ser Leu  Leu Glu Asn Ile Val  Asp Thr Leu 
    1175                 1180                 1185             


Lys Pro  Asn Glu Asp Gly Asp  Leu Val Ile Arg His  Thr Asp Leu 
    1190                 1195                 1200             


Met Ser  Glu Leu Ala Ala Tyr  Asp Gln His Arg Ser  Thr Val Phe 
    1205                 1210                 1215             


Lys Leu  Ile Gln Gln Ile Glu  Asn Leu Ile Ile Glu  Arg Asn Lys 
    1220                 1225                 1230             


Ala Leu  Lys Asn Pro Glu Ser  Glu Asp Phe Trp Val  Lys Glu Gly 
    1235                 1240                 1245             


Leu Pro  Lys Arg Asn Asn Phe  Ala Ser Leu Leu Glu  Leu Ile Asp 
    1250                 1255                 1260             


Gln Leu  Asn Asn Val Ala Leu  Thr Asp Glu Glu Arg  Lys Leu Leu 
    1265                 1270                 1275             


Val Ala  Val Arg Asn Ala Phe  Ser His Asn Ser Tyr  Asn Ile Asp 
    1280                 1285                 1290             


Phe Ser  Leu Ile Lys Asp Val  Lys His Leu Pro Glu  Val Ala Lys 
    1295                 1300                 1305             


Gly Ile  Leu Gln His Leu Glu  Ser Val Leu Gly Val  Ala Pro Thr 
    1310                 1315                 1320             


Lys 
    


<210>  2179
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2179

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Ile Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2180
<211>  948
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2180

Leu Phe Phe Ser Phe His Asn Ala Gln Arg Val Ile Phe Lys His Leu 
1               5                   10                  15      


Tyr Lys Ala Phe Asp Ala Ser Leu Arg Met Val Lys Glu Asp Tyr Lys 
            20                  25                  30          


Ala His Phe Thr Val Asn Leu Thr Arg Asp Phe Ala His Leu Asn Arg 
        35                  40                  45              


Lys Gly Lys Asn Lys Gln Asp Asn Pro Asp Phe Asn Arg Tyr Arg Phe 
    50                  55                  60                  


Glu Lys Asp Gly Phe Phe Thr Glu Ser Gly Leu Leu Phe Phe Thr Asn 
65                  70                  75                  80  


Leu Phe Leu Asp Lys Arg Asp Ala Tyr Trp Met Leu Lys Lys Val Ser 
                85                  90                  95      


Gly Phe Lys Ala Ser His Lys Gln Arg Glu Lys Met Thr Thr Glu Val 
            100                 105                 110         


Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu Glu Ser Arg 
        115                 120                 125             


Tyr Asp His Asn Gln Met Leu Leu Asp Met Leu Ser Glu Leu Ser Arg 
    130                 135                 140                 


Cys Pro Lys Leu Leu Tyr Glu Lys Leu Ser Glu Glu Asn Lys Lys His 
145                 150                 155                 160 


Phe Gln Val Glu Ala Asp Gly Phe Leu Asp Glu Ile Glu Glu Glu Gln 
                165                 170                 175     


Asn Pro Phe Lys Asp Thr Leu Ile Arg His Gln Asp Arg Phe Pro Tyr 
            180                 185                 190         


Phe Ala Leu Arg Tyr Leu Asp Leu Asn Glu Ser Phe Lys Ser Ile Arg 
        195                 200                 205             


Phe Gln Val Asp Leu Gly Thr Tyr His Tyr Cys Ile Tyr Asp Lys Lys 
    210                 215                 220                 


Ile Gly Asp Glu Gln Glu Lys Arg His Leu Thr Arg Thr Leu Leu Ser 
225                 230                 235                 240 


Phe Gly Arg Leu Gln Asp Phe Thr Glu Ile Asn Arg Pro Gln Glu Trp 
                245                 250                 255     


Lys Ala Leu Thr Lys Asp Leu Asp Tyr Lys Glu Thr Ser Asn Gln Pro 
            260                 265                 270         


Phe Ile Ser Lys Thr Thr Pro His Tyr His Ile Thr Asp Asn Lys Ile 
        275                 280                 285             


Gly Phe Arg Leu Gly Thr Ser Lys Glu Leu Tyr Pro Ser Leu Glu Ile 
    290                 295                 300                 


Lys Asp Gly Ala Asn Arg Ile Ala Lys Tyr Pro Tyr Asn Ser Gly Phe 
305                 310                 315                 320 


Val Ala His Ala Phe Ile Ser Val His Glu Leu Leu Pro Leu Met Phe 
                325                 330                 335     


Tyr Gln His Leu Thr Gly Lys Ser Glu Asp Leu Leu Lys Glu Thr Val 
            340                 345                 350         


Arg His Ile Gln Arg Ile Tyr Lys Asp Phe Glu Glu Glu Arg Ile Asn 
        355                 360                 365             


Thr Ile Glu Asp Leu Glu Lys Ala Asn Gln Gly Arg Leu Pro Leu Gly 
    370                 375                 380                 


Ala Phe Pro Lys Gln Met Leu Gly Leu Leu Gln Asn Lys Gln Pro Asp 
385                 390                 395                 400 


Leu Ser Glu Lys Ala Lys Ile Lys Ile Glu Lys Leu Ile Ala Glu Thr 
                405                 410                 415     


Lys Leu Leu Ser His Arg Leu Asn Thr Lys Leu Lys Ser Ser Pro Lys 
            420                 425                 430         


Leu Gly Lys Arg Arg Glu Lys Leu Ile Lys Thr Gly Val Leu Ala Asp 
        435                 440                 445             


Trp Leu Val Lys Asp Phe Met Arg Phe Gln Pro Val Ala Tyr Asp Ala 
    450                 455                 460                 


Gln Asn Gln Pro Ile Lys Ser Ser Lys Ala Asn Ser Thr Glu Phe Trp 
465                 470                 475                 480 


Phe Ile Arg Arg Ala Leu Ala Leu Tyr Gly Gly Glu Lys Asn Arg Leu 
                485                 490                 495     


Glu Gly Tyr Phe Lys Gln Thr Asn Leu Ile Gly Asn Thr Asn Pro His 
            500                 505                 510         


Pro Phe Leu Asn Lys Phe Asn Trp Lys Ala Cys Arg Asn Leu Val Asp 
        515                 520                 525             


Phe Tyr Gln Gln Tyr Leu Glu Gln Arg Glu Lys Phe Leu Glu Ala Ile 
    530                 535                 540                 


Lys His Gln Pro Trp Glu Pro Tyr Gln Tyr Cys Leu Leu Leu Lys Val 
545                 550                 555                 560 


Pro Lys Glu Asn Arg Lys Asn Leu Val Lys Gly Trp Glu Gln Gly Gly 
                565                 570                 575     


Ile Ser Leu Pro Arg Gly Leu Phe Thr Glu Ala Ile Arg Glu Thr Leu 
            580                 585                 590         


Ser Lys Asp Leu Thr Leu Ser Lys Pro Ile Arg Lys Glu Ile Lys Lys 
        595                 600                 605             


His Gly Arg Val Gly Phe Ile Ser Arg Ala Ile Thr Leu Tyr Phe Lys 
    610                 615                 620                 


Glu Lys Tyr Gln Asp Lys His Gln Ser Phe Tyr Asn Leu Ser Tyr Lys 
625                 630                 635                 640 


Leu Glu Ala Lys Ala Pro Leu Leu Lys Lys Glu Glu His Tyr Glu Tyr 
                645                 650                 655     


Trp Gln Gln Asn Lys Pro Gln Ser Pro Thr Glu Ser Gln Arg Leu Glu 
            660                 665                 670         


Leu His Thr Ser Asp Arg Trp Lys Asp Tyr Leu Leu Tyr Lys Arg Trp 
        675                 680                 685             


Gln His Leu Glu Lys Lys Leu Arg Leu Tyr Arg Asn Gln Asp Ile Met 
    690                 695                 700                 


Leu Trp Leu Met Thr Leu Glu Leu Thr Lys Asn His Phe Lys Glu Leu 
705                 710                 715                 720 


Asn Leu Asn Tyr His Gln Leu Lys Leu Glu Asn Leu Ala Val Asn Val 
                725                 730                 735     


Gln Glu Ala Asp Ala Lys Leu Asn Pro Leu Asn Gln Thr Leu Pro Met 
            740                 745                 750         


Val Leu Pro Val Lys Val Tyr Pro Thr Thr Ala Phe Gly Glu Val Gln 
        755                 760                 765             


Tyr His Glu Thr Pro Ile Arg Thr Val Tyr Ile Arg Glu Glu Gln Thr 
    770                 775                 780                 


Lys Ala Leu Lys Met Gly Asn Phe Lys Ala Leu Val Lys Asp Arg Arg 
785                 790                 795                 800 


Leu Asn Gly Leu Phe Ser Phe Ile Lys Glu Glu Asn Asp Thr Gln Lys 
                805                 810                 815     


His Pro Ile Ser Gln Leu Arg Leu Arg Arg Glu Leu Glu Ile Tyr Gln 
            820                 825                 830         


Ser Leu Arg Val Asp Ala Phe Lys Glu Thr Leu Ser Leu Glu Glu Lys 
        835                 840                 845             


Leu Leu Asn Lys His Ala Ser Leu Ser Ser Leu Glu Asn Glu Phe Arg 
    850                 855                 860                 


Thr Leu Leu Glu Glu Trp Lys Lys Lys Tyr Ala Ala Ser Ser Met Val 
865                 870                 875                 880 


Thr Asp Lys His Ile Ala Phe Ile Ala Ser Val Arg Asn Ala Phe Cys 
                885                 890                 895     


His Asn Gln Tyr Pro Phe Tyr Lys Glu Thr Leu His Ala Pro Ile Leu 
            900                 905                 910         


Leu Phe Thr Val Ala Gln Pro Thr Thr Glu Glu Lys Asp Gly Leu Gly 
        915                 920                 925             


Ile Ala Glu Ala Leu Leu Lys Val Leu Arg Glu Tyr Cys Glu Ile Val 
    930                 935                 940                 


Lys Ser Gln Ile 
945             


<210>  2181
<211>  1137
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2181

Met Glu Asn Asn Asn Leu Gly Asn Gly Ile Val Tyr Asp Tyr Ala Ile 
1               5                   10                  15      


Ile Ala Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Lys Asp 
            20                  25                  30          


Asn Ile Asp Ala Val Phe Lys Ala Tyr Glu Asp Arg Phe Gly Glu Asn 
        35                  40                  45              


Val Pro Asp Met Lys Ile Glu Asn Leu Ser Tyr Gln Asp Tyr Gln Asn 
    50                  55                  60                  


Arg Ile Asp Phe Leu Lys Tyr Tyr Phe Pro Val Ile Asn Tyr Leu Asp 
65                  70                  75                  80  


Leu Pro Val Ser Asp Lys Glu Phe Glu Asn Ile Arg Asp Lys Glu Pro 
                85                  90                  95      


Lys Arg Arg Lys Tyr Phe Arg Glu Asn Phe Lys Thr Leu Tyr Lys Ala 
            100                 105                 110         


Val Ser Ala Leu Arg His Phe Tyr Thr His Tyr Tyr His Glu Pro Leu 
        115                 120                 125             


Ser Phe Glu Met Asn Leu Phe Ser Leu Leu Asp Lys Ile Phe Ile Ser 
    130                 135                 140                 


Val Ile Glu Asp Ile Lys Lys Glu Lys Lys Asn Asp Asn Lys Thr Arg 
145                 150                 155                 160 


Pro Leu Leu Asn Arg Asn Leu Lys Glu Glu Leu Lys Cys Leu Met Ala 
                165                 170                 175     


Leu Lys Lys Gln Glu Leu Lys Glu Lys Gln Lys Ser Gln Lys Asn Ile 
            180                 185                 190         


Ser Leu Asp Glu Val Ser Ile Gln Asn Ala Val Phe Asn Asp Ala Phe 
        195                 200                 205             


Ser Gln Phe Phe Asn Lys Glu Lys Lys Ile Ser Arg Phe Tyr Gln Ala 
    210                 215                 220                 


Glu Asn Thr Asp Thr Asp Ile Glu Asn Lys Leu Asn Ile Ser Gln Thr 
225                 230                 235                 240 


Gly Leu Leu Phe Leu Leu Gly Met Phe Leu Thr Lys Lys Gln Ser Glu 
                245                 250                 255     


Asp Leu Arg Ser Arg Ile Arg Arg Phe Lys Asn Lys Ile Ile Lys Asn 
            260                 265                 270         


Gln Asp His Pro Val Ser Lys Gln Asn Asn Ser Leu Lys Tyr Met Ser 
        275                 280                 285             


Thr Gln Trp Val Phe Gly Tyr Leu Ala Phe Lys Gly Leu Lys Ser Thr 
    290                 295                 300                 


Leu Asn Thr Thr Phe Met Gln Glu Thr Leu Leu Thr Gln Ile Val Asp 
305                 310                 315                 320 


Glu Leu Ser Lys Val Pro Asn Glu Ile Tyr Arg Asn Leu Ser Gln Glu 
                325                 330                 335     


Gln Gln Gln Leu Phe Ile Glu Asp Met Asn Glu Tyr Val Gln Asp Gly 
            340                 345                 350         


Asn Asn Val Lys Ser Leu Glu Asp Ala Ile Val Ile His Pro Val Ile 
        355                 360                 365             


Arg Lys Arg Tyr Glu Asp Lys Phe Pro Tyr Phe Val Ile Arg Tyr Leu 
    370                 375                 380                 


Asp Glu Tyr Ala Gly Phe Pro Thr Leu Lys Phe Gln Ile Gln Leu Gly 
385                 390                 395                 400 


Asn Tyr Val His Asp Lys Arg Thr Lys Lys Ile Gln Gly Thr Val Tyr 
                405                 410                 415     


Ser Thr Glu Arg Val Val Lys Glu Lys Ile Thr Val Phe Gly Lys Leu 
            420                 425                 430         


Ser Glu Ile Thr Ala Leu Lys Asp Asn Tyr Leu Lys Lys Arg Thr Gln 
        435                 440                 445             


Asn Asn Glu Glu Asn Arg Gly Trp Glu Ile Tyr Pro Asn Pro Ser Tyr 
    450                 455                 460                 


Asn Phe Thr Gly Asn Asn Ile Pro Ile Tyr Leu Asp Leu Glu Ser Ser 
465                 470                 475                 480 


Asn Val Pro Gly Ala Lys Gln Leu Tyr Gly Asn Ile Gln Lys Gln Cys 
                485                 490                 495     


Ala Asp Leu Arg Lys Lys Asn Ile Glu Asn Gln Asp Gln Thr Glu Arg 
            500                 505                 510         


Ala Asp Lys Ala Thr Lys His Asp Ile Val Lys Leu Ile Asp Ser Lys 
        515                 520                 525             


Lys Ile Val Ile Lys Lys Pro Thr Ala Phe Leu Ser Leu Asn Glu Leu 
    530                 535                 540                 


Ser Gly Leu Leu Tyr Glu Leu Leu Val Asn Lys Lys Asn Gly Lys Gln 
545                 550                 555                 560 


Ile Glu Asp Ile Leu Ile Lys Lys Leu Ile Glu His Tyr Asp Thr Ile 
                565                 570                 575     


Ser Glu Phe Ser Thr Glu Asn Pro Leu Pro Thr Ser Gln Ile Thr Lys 
            580                 585                 590         


Lys Leu Leu Lys Ser Asn Ser Glu Ser Gln Trp Asn Thr Gly Lys Leu 
        595                 600                 605             


Met Arg Asp Ile Glu Arg Glu Ile Ala Val Thr Glu His Lys Leu Asn 
    610                 615                 620                 


Leu Ile Lys Asp Lys Arg Asp Ser Leu Ser Arg Tyr Asn Leu Lys Glu 
625                 630                 635                 640 


Lys Ile Arg Lys Pro Val Phe Ser Asn Arg Ala Ala Gly Lys Glu Ala 
                645                 650                 655     


Val Trp Ile Ala Glu Asp Leu Val Arg Phe Met Pro Lys Ala Val Arg 
            660                 665                 670         


Lys Asn Trp Lys Gly Tyr His His Ser Gln Leu Gln Gln Ser Leu Ala 
        675                 680                 685             


Phe Tyr Glu Gln Arg Pro Asn Glu Ala Val Asn Leu Val Lys Gln Tyr 
    690                 695                 700                 


Trp Asn Leu Asn Asp Thr Arg Tyr Cys Trp Asn Glu Gly Ile Lys Lys 
705                 710                 715                 720 


Ser Phe Glu Arg Ser Glu Phe Asp Leu Phe Tyr Glu Ala Tyr Leu Lys 
                725                 730                 735     


Asn Arg Lys Lys Ile Leu Asn Leu Tyr Arg Asp Lys Leu Ser Asp Asn 
            740                 745                 750         


Met Glu Asn Met Glu Ser Met Met Gln Asp Glu His Leu Asp Phe Ile 
        755                 760                 765             


Phe Asn Arg His Leu Tyr Lys Ile Asp Thr Thr Glu Asn Gln Lys Leu 
    770                 775                 780                 


Lys Leu Leu Ala His Pro Phe Val Phe Pro Arg Gly Ile Phe Asp Glu 
785                 790                 795                 800 


Lys Pro Thr Tyr Ile Lys Gly Lys Ser Met Thr Glu Thr Pro Glu Leu 
                805                 810                 815     


Tyr Ala Glu Trp Tyr Arg Tyr Ala Asn Gln Arg Ile Glu Ser Gln Gln 
            820                 825                 830         


Phe Phe Tyr Lys Thr Pro Arg Asp Tyr Lys Asp Leu Tyr Asn Thr Met 
        835                 840                 845             


Lys Glu His Lys Lys Glu Ile Asp Glu Asn Lys Tyr Asn Leu Ser Glu 
    850                 855                 860                 


Ile Glu Lys Tyr Asn Leu Phe Lys Asn Lys Gln Asp Lys Ala Ile Lys 
865                 870                 875                 880 


Lys Val Gln Met Gln Asp Val Phe Leu Glu Leu Ile Val Lys Asp Leu 
                885                 890                 895     


Phe Asn Arg Ile Phe Pro Asn Gln Gly Cys Asp Phe Ser Leu Lys Asp 
            900                 905                 910         


Phe Thr Asp Ile His Asn Asp Thr Trp Asn Ile Ser Val Pro Phe Gln 
        915                 920                 925             


Trp Lys Gln Ile Arg Glu Pro Glu Val Lys Leu Lys Asp Ile Gly Lys 
    930                 935                 940                 


Phe Lys Arg Phe Leu Phe Asp Lys Lys Ile Glu Asn Ile Leu Ser Tyr 
945                 950                 955                 960 


Asn Glu Asp Lys Ile Trp Thr Lys Arg Glu Leu Glu Glu Glu Leu Glu 
                965                 970                 975     


Leu Leu Pro Ser Ser Tyr Glu Val Ile Arg Arg Glu Gln Leu Leu Lys 
            980                 985                 990         


Leu Ile Gln Glu Leu Glu Asn Cys  Ile Leu Gln Lys Asn  Asn Phe Asp 
        995                 1000                 1005             


Gly Val  Asn His Pro Lys Glu  Phe Glu Gln Ser Asp  Glu Asp Lys 
    1010                 1015                 1020             


Lys Ala  Tyr Pro Asn Phe Lys  His Tyr Ile Thr Glu  Gly Ile Leu 
    1025                 1030                 1035             


Lys Lys  Cys Thr Leu Ala Glu  Asn Thr Asp Ile Glu  Trp Leu Asn 
    1040                 1045                 1050             


Gln Leu  Lys Glu Asp Thr Phe  Glu Lys Val Pro Leu  Gln Glu Leu 
    1055                 1060                 1065             


Cys Met  Lys Pro Lys Ile Ile  Gln Lys Ala Tyr Leu  Leu Val Leu 
    1070                 1075                 1080             


Ile Arg  Asn Lys Ile Ser His  Asn Gln Leu Pro Lys  Lys Glu Tyr 
    1085                 1090                 1095             


Phe Glu  Arg Ile Lys Thr Met  Phe Ser Pro Ala Glu  Ala Asn Glu 
    1100                 1105                 1110             


Thr Ile  Ser Tyr Ser Ser Ile  Ile Leu Asn Phe Thr  Lys Ser Val 
    1115                 1120                 1125             


Ile Gln  Glu Leu Lys Thr Tyr  Leu Lys 
    1130                 1135         


<210>  2182
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2182

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2183
<211>  1200
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2183

Met Gln Glu Glu Ile Ile Ser Ala Asp Pro Lys Thr Lys Gln Thr Lys 
1               5                   10                  15      


Phe Asn His Tyr Ser Glu Glu Asp Lys Tyr Phe Phe Gly Gly Phe Leu 
            20                  25                  30          


Asn Asn Ala Asp Asp Asn Leu Lys Gln Val Ser Lys Glu Phe Lys Glu 
        35                  40                  45              


Arg Leu Asn Ile Ile Gly Gln Asn Glu Asn Thr Ser Thr Ser Asn Asp 
    50                  55                  60                  


Asp Asp Asn Leu Asn Ser Val Val Lys Gln Tyr Ile Asn Asn Asn Lys 
65                  70                  75                  80  


Ser Leu Ala Lys Lys Glu Lys Ala Ile Asn Ile Leu Ile Asp Tyr Phe 
                85                  90                  95      


Pro Ile Val Ala Ala Val Lys Lys Tyr Cys Ser Asn Asn Ile Asp Glu 
            100                 105                 110         


Thr Phe Glu Leu Phe Lys Leu Leu Leu Gly Thr Val Ala Asp Leu Arg 
        115                 120                 125             


Asn Phe Tyr Thr His Tyr Tyr His Lys Pro Ile Thr Ile Asp Glu Lys 
    130                 135                 140                 


Val Tyr Asp Phe Leu Asp Asn Thr Leu Phe Asp Val Phe Met Thr Ile 
145                 150                 155                 160 


Lys Lys Lys Lys Val Lys Asn Asp Lys Ser Lys Glu Leu Leu Lys Glu 
                165                 170                 175     


Lys Leu Arg Pro Glu Leu Lys Leu Leu Ile Asn Leu Lys Arg Lys Glu 
            180                 185                 190         


Leu Ile Gln Lys Gly Lys Lys Thr Glu Asn Leu Glu Asn Ala Val Phe 
        195                 200                 205             


Asn His Cys Leu Arg Pro Phe Leu Glu Glu Thr Lys Asn Ser Lys Asn 
    210                 215                 220                 


Lys Thr Ile Ser Leu Arg Ser Tyr Lys Lys Ser Lys Pro Glu Glu Glu 
225                 230                 235                 240 


Thr Thr Val Pro Ile Thr Gln Ser Gly Leu Val Phe Leu Met Ser Phe 
                245                 250                 255     


Phe Leu His Arg Lys Asp Phe Gln Leu Phe Ile Ser Gly Leu Glu Gly 
            260                 265                 270         


Phe Lys Gly Lys Val Asn Ala Val Gln Glu Glu Glu Ile Thr Leu Lys 
        275                 280                 285             


Lys Asn Asn Leu Val Tyr Met Ile Ser His Trp Ser Tyr Ser Tyr Tyr 
    290                 295                 300                 


Asn Phe Lys Gly Leu Lys His Arg Ile Lys Thr Asp Gln Gly Val Asn 
305                 310                 315                 320 


Glu Ile Glu Tyr Asp Gly Ile Thr His Thr Ile Thr Asn Lys Asp Thr 
                325                 330                 335     


Lys Glu Ala Leu Leu Thr Gln Leu Val Asp Tyr Leu Ser Lys Val Pro 
            340                 345                 350         


Asp Glu Val Tyr Asn Asn Leu Ser Glu Glu Gln Gln Asn Glu Phe Leu 
        355                 360                 365             


Glu Asp Val Asn Glu Tyr Met Arg Asp Asn Pro Glu Asn Glu Asp Ser 
    370                 375                 380                 


Ser Ile Ser Ser Ile Val Ser His Gln Val Ile Arg Lys Arg Tyr Glu 
385                 390                 395                 400 


Asn Lys Phe Asn Tyr Phe Ala Leu Arg Phe Ile Asp Glu Tyr Gly Asn 
                405                 410                 415     


Leu Pro Ser Phe Arg Phe Met Val Asn Phe Gly Ser Tyr Ile Lys Asp 
            420                 425                 430         


Arg Lys Lys Lys Val Leu Asp Ser Ile Asn Tyr Asn Ser Glu Arg Ile 
        435                 440                 445             


Ile Lys Lys Glu Ile His Leu Phe Glu Lys Leu Ser Met Val Thr Asp 
    450                 455                 460                 


Tyr Lys Lys Asn Leu Phe Leu Asn Glu Thr Ala Thr Leu Asn Leu Ala 
465                 470                 475                 480 


Gln Phe Pro Leu Phe Pro Asn Pro Ser Tyr Val Ile Ala Asn Asn Asn 
                485                 490                 495     


Ile Pro Phe Tyr Ile Asn Cys Gln Lys Asn Asp Leu Asn Asp Tyr Phe 
            500                 505                 510         


Gly Lys Lys Lys Ser Ser Gln Ser Gln Asn Gln Lys Lys Asn His Thr 
        515                 520                 525             


Tyr Asp Lys Asp Asn Lys Gly Gln Thr Ser Ser Asn Ile Val Gly Glu 
    530                 535                 540                 


Leu Glu Lys Ala Leu Gly Val Lys Asp Ile Lys Gln Arg Ser Thr Ile 
545                 550                 555                 560 


Gly Leu Phe Ser Cys Asn Glu Leu Ser Ser Met Leu His Glu Ile Ile 
                565                 570                 575     


Val Lys Lys Thr Ser Gly Val Asp Leu Glu Asn Arg Ile Ala Gln Lys 
            580                 585                 590         


Ile Lys Glu Gln Tyr Gln Ile Ile Lys Asp Phe Asp Ser Asn Ser Tyr 
        595                 600                 605             


Asp Glu Ser Ala Lys Asn Lys Ile Pro Lys Ala Leu Leu Lys Thr Ser 
    610                 615                 620                 


Lys Val Asp Ser Thr Ile Thr Phe Glu Gly Lys Gln Ile Asp Leu Ala 
625                 630                 635                 640 


Arg Leu Ile Asn Ala Val Thr Phe Glu Leu Asp Ala Thr His Ala Lys 
                645                 650                 655     


Ile Lys Thr Val Lys Glu Arg Glu Glu Glu Val Arg Lys Gly Glu Ile 
            660                 665                 670         


Glu Lys Asn Gln Lys Asn Ser Ser Asn Lys Gln Lys Thr Lys Val Lys 
        675                 680                 685             


Tyr Arg Lys Tyr Val Phe Tyr Asn Asn Glu Ile Gly Gln Glu Ala Ser 
    690                 695                 700                 


Trp Leu Ala Gly Asp Leu Ile Arg Tyr Met Lys Asn Asn Ala Thr Trp 
705                 710                 715                 720 


Lys Gly Tyr Met His Ser Glu Leu Gln Ala Leu Leu Ala Phe Tyr Glu 
                725                 730                 735     


Glu Lys Arg Asn Asp Ile Ile Thr Ile Leu Glu Asn Thr Phe Asn Leu 
            740                 745                 750         


Lys Ala Asp Cys Leu Leu Thr Ile Asp Leu Lys Ser Leu Leu Val Lys 
        755                 760                 765             


Asn His Lys Phe Ile Asp Phe Tyr Lys Asp Tyr Leu Ser Leu Lys Arg 
    770                 775                 780                 


Ser Phe Leu Asn Glu Lys Leu Met Phe Leu Lys Asn Asn Asp Phe Asn 
785                 790                 795                 800 


Gly Ile Pro Ala Lys Thr Leu Lys Lys Glu Trp Asn Ser Val Phe Glu 
                805                 810                 815     


Val Phe Lys Lys Arg Gln Tyr Leu Ile Gln Ser Thr Glu Glu Lys Lys 
            820                 825                 830         


Gln Asn Leu Tyr Gly Asp Ala Ile Asn Leu Ser Arg Gly Ile Phe Asp 
        835                 840                 845             


Asp Lys Pro Thr Met Ile Pro Asn Lys Gln Pro Asn Arg Glu Glu Phe 
    850                 855                 860                 


Ala Ala Trp Phe Val Ala Pro Thr Val Tyr Glu His Tyr Gln Ser Phe 
865                 870                 875                 880 


Tyr Asn Leu Ile Asp Leu Asn Asn Pro Lys Thr Asp Thr Lys Glu Gln 
                885                 890                 895     


Thr Lys Gln Asn Tyr Lys Thr Ile Arg Thr Leu Asn Lys Ile Lys Ile 
            900                 905                 910         


Gln Asp Tyr Tyr Leu Lys Leu Met Val Asp Ala Leu Tyr Lys Asp Leu 
        915                 920                 925             


Phe Gly Gln Glu Leu Asn Ile Glu Leu Lys Asp Phe Tyr Val Pro Lys 
    930                 935                 940                 


Ser Glu Arg Glu Ser Ile Lys Ala Asp Ala Lys Asn Tyr Gln Gln Val 
945                 950                 955                 960 


Asp Asn Ser Phe Leu Trp Asn Lys Val Val His His Thr Leu Gln Gly 
                965                 970                 975     


Gly Arg Ile Asn Ala Thr Ala Lys Leu Lys Asp Ile Gly Lys Tyr Lys 
            980                 985                 990         


Arg Ala Met Lys Asp Glu Lys Ile  Ala Ser Leu Leu Thr  Tyr Asp Asp 
        995                 1000                 1005             


Arg Thr  Trp Thr Tyr Ala Leu  Asp Asn Ile Lys Asp  Glu Ser Lys 
    1010                 1015                 1020             


Gln Thr  His Leu Tyr Ser Leu  Thr Met Glu Leu Gln  Glu Tyr Glu 
    1025                 1030                 1035             


Lys Val  Arg Ser Lys Glu Leu  Leu Lys Gln Val Gln  Gln Leu Glu 
    1040                 1045                 1050             


Lys Glu  Ile Leu Asn Leu Asp  Glu Asp Phe Val Thr  Thr Gln Asn 
    1055                 1060                 1065             


His Pro  Ile Ile Phe Glu Val  Ala Asn Asn Pro Arg  Phe Arg Lys 
    1070                 1075                 1080             


Tyr Ile  Glu Glu Gly Ile Leu  Asn Lys Ile Leu Pro  Asn Glu Asn 
    1085                 1090                 1095             


Gln Val  Glu Ile Leu Arg Gly  Ile Asp Phe Asp Asp  Leu Ser Trp 
    1100                 1105                 1110             


Ala Phe  Asp Ser Ser Glu Arg  Asn Glu Glu Gln Lys  Glu Lys Ile 
    1115                 1120                 1125             


Asn Leu  Tyr Asn Gln Ile Thr  Asn Pro Gln Val Gln  Arg Gly Leu 
    1130                 1135                 1140             


Ile Leu  Ile Met Ile Arg Asn  Lys Ile Ala His Asn  Gln Tyr Pro 
    1145                 1150                 1155             


Pro Lys  Tyr Ile Tyr Asp Leu  Ala Gln Thr Phe Ile  Pro Lys Glu 
    1160                 1165                 1170             


Glu Asn  Glu Tyr Phe Ala Ser  Tyr Phe Asn Arg Val  Phe Lys Glu 
    1175                 1180                 1185             


Met Thr  Lys Lys Leu Leu Gln  Ser Leu Glu Asn Asn  
    1190                 1195                 1200 


<210>  2184
<211>  1140
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2184

Met Glu Asn Asp Gln Gln Ile Leu Glu Asn Arg Arg Arg Thr Leu Ala 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Ser Asn His Leu Ala Ala Ser Phe Glu Gln Lys Val 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ala Ser Phe Leu Cys Asn Lys Ser 
    50                  55                  60                  


Ile Lys Lys Ile Asn Trp Asn His Val Tyr Ser Lys Ala Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ala Asp Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Arg Glu Thr Thr Asp Lys Glu Gly Lys Asp Phe Thr Ala Met Asn Glu 
            100                 105                 110         


Thr Leu Lys Leu Val Phe Asp Glu Leu Gln Ala Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Ala Asp Ser Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Val Glu Leu Ala Asp Phe Leu Thr Val Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Ala Asp Asp Asp Tyr 
                165                 170                 175     


Thr Met Val Glu Ser Lys Gln Ile Val Thr Pro Asp Asn Leu Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Val Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Leu Ala Tyr Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asp Leu Gly Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Glu 
            260                 265                 270         


Val Ile Thr Glu Glu Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Glu Glu Glu Arg 
    290                 295                 300                 


Glu Lys Ile Leu Asp Glu Ile Asp Tyr Glu Asp Tyr Ile Glu Ser Leu 
305                 310                 315                 320 


Thr Arg Arg Val Arg His Ser Asn Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Lys Tyr Asn Lys Gln Phe Asp Gly Glu 
        355                 360                 365             


Ala Thr Glu Cys Lys Val Val Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asn Gln Glu Thr Val Glu Leu Lys Ile Asp Ser Ala 
385                 390                 395                 400 


Gln Arg Thr Asn Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Glu Ala Arg Leu Leu 
            420                 425                 430         


Thr Lys Ala Lys Pro Glu Ser Lys Val Ser Tyr Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Lys Ala Glu Glu Met Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Lys Val Asn Asp Ser Gln Leu Met Ser Met Gln Phe Ile Asp Glu 
                485                 490                 495     


Ile Lys Glu Gln Leu Pro Ala Asp Trp Asn Glu Phe Gly Lys Arg Ser 
            500                 505                 510         


Asp Ser Lys Lys Lys Lys Ala Tyr Thr Asn Ala Ala Leu Gln Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Lys Val Leu Ala Asn Tyr Gln Leu 
    530                 535                 540                 


Asn Asp Lys Gln Val Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Ser Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Val Glu Lys His Lys Leu 
            580                 585                 590         


Asp Lys Ser Ala Arg Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Thr Asp Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Phe Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Tyr 
625                 630                 635                 640 


Ala Asp Thr Asp Lys Lys Ala Thr Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Lys Gly Gly His Pro Phe Leu Ala Asn Ile Asn 
            660                 665                 670         


Leu Arg Gln Ile Arg Lys Thr Ser Gln Leu Tyr Glu Leu Tyr Leu Val 
        675                 680                 685             


Glu Lys Ala Asn Lys Gln Val Lys Lys Met Asn Pro Lys Thr Gln Arg 
    690                 695                 700                 


Thr Ser Asn Val Asp Glu Ser Trp Met Met Lys Ser Phe Tyr Ala Lys 
705                 710                 715                 720 


Glu Trp Asn Glu Glu Met Gly Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Val Asn Lys Thr Asn Ile Pro Phe Thr Ile Arg Gln Trp Glu Glu Lys 
            740                 745                 750         


Glu Lys His Asn Leu Gln Ala Trp Leu His Asn Ile Thr Lys Gly Lys 
        755                 760                 765             


Thr Ser Lys Asp Gly Lys Lys Ala Ile Asp Leu Pro Thr Asn Leu Phe 
    770                 775                 780                 


Asp Asp Thr Leu Cys Glu Leu Leu Arg Glu Ala Leu Ile Asn Gln Gly 
785                 790                 795                 800 


Ile Asp Ala Thr Pro Thr Thr Lys Tyr Asn Glu Leu Leu Lys Gln Trp 
                805                 810                 815     


Trp Thr Ala Arg Glu Asp Ser Thr Gln Asp Phe Tyr Leu Ser Glu Arg 
            820                 825                 830         


Gln Tyr Asp Ile Tyr Asp Glu Lys Val Cys Phe Thr Ile Asn Ser Ser 
        835                 840                 845             


Ala His Phe Ala Asp Tyr Tyr Ala Pro Ala Leu Asn Lys Ala Tyr Ser 
    850                 855                 860                 


Arg Leu Arg Ala Glu Arg Asp Val Ala Arg Arg Thr Asp Lys Arg Leu 
865                 870                 875                 880 


Pro Pro Val Glu Arg Lys Asp Val Glu Arg Val Phe Lys Asn Thr Ile 
                885                 890                 895     


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
            900                 905                 910         


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asn Gln Gln Gln Leu Lys 
        915                 920                 925             


Leu Ser Lys Met Asp Ser Leu Leu Asn Glu Thr Lys Arg Ile Glu Gln 
    930                 935                 940                 


Thr Ile Asn Thr Gln Leu Ser Phe Asp His Lys Gly Lys Glu Ile Lys 
945                 950                 955                 960 


Asp Lys Thr Asn Ser Glu Ile Val Lys Thr Ile Val Ala Glu Arg Lys 
                965                 970                 975     


Gln Lys Asn Tyr Thr Glu Met Arg Lys Tyr Val His Asp Arg Arg Leu 
            980                 985                 990         


Pro Glu Leu Phe Glu Tyr Ile Asp  Gly Asn Glu Leu Pro  Leu Asp Val 
        995                 1000                 1005             


Leu Leu  Asn Glu Leu Arg Ala  Tyr Asn Thr Ala Lys  Gln Met Val 
    1010                 1015                 1020             


Phe Asp  Thr Val Phe Ala Leu  Glu Lys Lys Ile Ile  Glu Thr Asp 
    1025                 1030                 1035             


Pro Glu  Gly Leu Lys Gln Leu  Asn Val Gly Lys Asn  Gly Gln Ile 
    1040                 1045                 1050             


Gln Thr  Gly Asn Ile Gln His  Lys Pro Tyr Val Gln  Trp Leu Glu 
    1055                 1060                 1065             


Asn Lys  Gly Leu Ile Thr Asp  His Gln Lys Gln Phe  Ile Asn Met 
    1070                 1075                 1080             


Val Arg  Asn Ser Phe Ser His  Asn Gln Phe Pro Gln  Arg Ser Thr 
    1085                 1090                 1095             


Val Glu  Leu Leu Met Pro Glu  Trp Gln Asn Thr Asp  Ile Ala Leu 
    1100                 1105                 1110             


Gln Ile  Ala Arg Glu Tyr Gln  Gln Leu Ile Val Asp  Ile Ile Glu 
    1115                 1120                 1125             


Lys Ser  Leu His Pro His Lys  Gln His Gln Met Val  
    1130                 1135                 1140 


<210>  2185
<211>  1129
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2185

Met Glu Thr Asn Gln Gln Thr His Glu Asn Arg Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Asn Asn His Ile Ala Thr Asp Phe Lys Gln Ala Thr 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ala Ala Phe Leu Cys Asn Lys Thr 
    50                  55                  60                  


Ile Lys Asn Leu Asn Trp Asn His Val His Thr Arg Ala Val Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ser Glu Ser Leu Pro Lys Asp Glu 
                85                  90                  95      


Arg Glu Asn Ser Asp Thr Glu Gly Lys Asp Phe Ala Ser Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Ser Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gln Asp Ser Arg Lys Leu Thr Val 
    130                 135                 140                 


Ser Pro Glu Leu Ala Asn Phe Leu Thr Val Asn Phe Gln Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Ala Arg Met Lys Asp Val Leu Thr Asp Ala Asp Tyr 
                165                 170                 175     


Ala Leu Val Glu Asn Leu Gln Met Val Ala Pro Asp Asn Lys Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ala Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Thr Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asn Leu Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Ser 
            260                 265                 270         


Val Ile Thr Asp Lys Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Asp Asp Glu Arg 
    290                 295                 300                 


Glu Arg Ile Leu Asp Glu Ile Asp Tyr Gln Asp Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg Tyr Ser Asn Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Asp Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Asn Tyr Thr Lys Gln Phe Ala Gly Glu 
        355                 360                 365             


Gln Ala Glu Arg Lys Val Leu Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asp Pro Glu Leu Ile Gln Gln Arg Ile Asp Lys Gln 
385                 390                 395                 400 


Gln His Thr Ala Gly Phe Asp Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Thr Lys Glu Asn Ile Ala Thr Leu Ile 
            420                 425                 430         


Ala Lys Ser Lys Ala Ser Ser Lys Val Glu His Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Gln Ala Glu Glu Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Ile Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Ser Gln Leu Pro Ala Asp Trp Asp Glu Phe Ser Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asp Ser Thr Leu Lys Tyr Leu 
        515                 520                 525             


Arg Gln Arg Lys Thr Thr Leu Asn Thr Ile Leu Ser Lys Ser Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Lys Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Thr Arg Leu Lys Ala Val Glu Lys His Lys Leu 
            580                 585                 590         


Asn Lys Ser Val Lys Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Glu Glu Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Ala Asn Ala Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Asn Asp Gly His Pro Phe Leu Gln Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Gln Ala Tyr Leu Ile 
        675                 680                 685             


Glu Lys Gly Asn Lys Met Val Pro Arg Leu Asn Pro Lys Thr Asn Lys 
    690                 695                 700                 


Thr Ser Lys Val Asp Glu Ser Trp Met Met Lys Gln Phe Tyr Val Lys 
705                 710                 715                 720 


Glu Trp Lys Glu Glu Ile Ala Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Ser Arg Ile Pro Phe Thr Ile Arg Gln Trp Asp Glu Lys 
            740                 745                 750         


Glu Lys Tyr Asp Leu Asn Thr Trp Leu Arg His Val Thr Val Gly Lys 
        755                 760                 765             


Asn Asn Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe Asp 
    770                 775                 780                 


Glu Ala Leu Cys Asp Leu Leu Arg Glu Gln Leu Asp Thr Lys Ile Val 
785                 790                 795                 800 


Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Ile Trp Trp 
                805                 810                 815     


Lys Thr Arg Asn Asp Asp Thr Gln Gln Phe Tyr Gln Ser Glu Arg Glu 
            820                 825                 830         


Tyr Asn Ile Tyr Asn Glu Lys Val Arg Phe Lys Ile Asp Ser Ser Ala 
        835                 840                 845             


His Phe Ala Asp Tyr Tyr Lys Asn Ala Leu Ser Arg Ala Phe Thr Arg 
    850                 855                 860                 


Leu Lys Ala Glu Arg Glu Thr Ala Arg Gln Ser Asn Lys Arg Leu Pro 
865                 870                 875                 880 


Pro Leu Glu Tyr Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile Ala 
                885                 890                 895     


Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met Ala 
            900                 905                 910         


Val Leu Met Leu Glu Arg Leu Met Asp Asn Ser Pro Asn Leu Arg Leu 
        915                 920                 925             


Ser Lys Ile Glu Thr Leu Leu Asn Asp Thr Thr Pro Ile Arg Glu Lys 
    930                 935                 940                 


Ile Ser Ala Thr Leu Ser Phe Asp Ala Ser Gly Glu Arg Ile Ser Gly 
945                 950                 955                 960 


Lys Ser Asn Pro Thr Val Thr Lys Thr Leu Val Ala Glu Arg Lys Gln 
                965                 970                 975     


Lys Asn Tyr Thr Glu Leu Arg Lys Tyr Arg Tyr Asp Arg Arg Leu Pro 
            980                 985                 990         


Glu Leu Phe Glu Tyr Val Gln Ala  Asp Glu Ile Pro Leu  Glu Trp Leu 
        995                 1000                 1005             


Leu Glu  Glu Leu Ser Ala Tyr  Asn Asn Ala Lys Gln  Gln Val Phe 
    1010                 1015                 1020             


Asp Thr  Val Phe Thr Leu Glu  Lys Lys Ile Ile Gly  Thr Asp Pro 
    1025                 1030                 1035             


Asp Gly  Leu Lys Ser Leu Phe  Thr Gly Ala Asn Gly  Glu Leu Gln 
    1040                 1045                 1050             


Thr Gly  Asn Ile Gln His Lys  Pro Tyr Val Gln Trp  Leu Thr Asn 
    1055                 1060                 1065             


Lys Gly  Leu Ile Asn Lys Glu  Glu Lys Gln Phe Ile  Asn Met Val 
    1070                 1075                 1080             


Arg Lys  Cys Phe Ser His Asn  Gln Phe Pro Gln Arg  Lys Thr Met 
    1085                 1090                 1095             


Glu Leu  Leu Ile Pro Ala Trp  Asn Glu Lys Lys Leu  Ala Leu Gln 
    1100                 1105                 1110             


Ile Ala  Thr Val Tyr Asn Gln  Leu Ile Ala Asp Leu  Thr Asn Lys 
    1115                 1120                 1125             


Ile 
    


<210>  2186
<211>  1090
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2186

Met Asn Asn Phe Phe Lys Lys Tyr Gln Ser Glu Phe Ser Ala Tyr Tyr 
1               5                   10                  15      


Asn Met Ala Arg Gln Asn Ala Tyr Ile Thr Leu Gln His Ile Ser Asn 
            20                  25                  30          


Ile Met Gly Tyr Lys Glu Gly Glu Gly Lys Glu Ser Arg Leu Phe Glu 
        35                  40                  45              


Met Gln Ser Val Met Gln Val Thr Lys Glu Lys Pro Asn Gln Gln Ile 
    50                  55                  60                  


Phe Leu Leu Lys Gln Leu Ser Arg Phe Phe Pro Val Leu Arg Ile Met 
65                  70                  75                  80  


Ala Glu Cys Glu Arg Lys Lys Gly Gln Leu Ala Ser Gly Ser Pro Glu 
                85                  90                  95      


Ser Ile Arg Lys Val Leu Val Asn Ile Phe Asn Val Leu Asn Tyr Glu 
            100                 105                 110         


Arg Asp Arg Ala Ser His Leu Ser Phe Val Asp Glu Arg Thr Asp Ser 
        115                 120                 125             


Glu Lys Tyr Ile Glu Lys Glu Arg Gln Val Ala Tyr Tyr Leu Asn His 
    130                 135                 140                 


Cys Tyr Thr Val Ala Val Arg Thr Ile Lys Thr Arg Phe Gly Lys Glu 
145                 150                 155                 160 


Thr Lys Asp Met Glu Ile Phe Thr Lys Glu Arg Tyr Lys Phe Thr Thr 
                165                 170                 175     


Glu Phe Val Asp Gly Lys Lys Ile Arg Lys Ala Glu Ile Asn Tyr Asn 
            180                 185                 190         


Phe Pro Phe Ser Met Val Asp Lys Asp Lys Arg Leu Thr Asp Leu Gly 
        195                 200                 205             


Arg Val Phe Leu Ile Ser Leu Phe Ile Glu Lys Arg Tyr Ala Ser Ile 
    210                 215                 220                 


Phe Phe Asp Ser Leu Gln Thr Asn Asn Lys Ser Asp Ile Tyr Lys Asn 
225                 230                 235                 240 


Leu Asn Glu Glu Gln Lys Ser Leu Leu Arg Glu Ile Phe Ser Ala Phe 
                245                 250                 255     


Arg Ile Arg Leu Pro Lys Glu Arg Leu Gly Asn Glu Arg Ser Asp Ile 
            260                 265                 270         


Leu Leu Ala Leu Asp Met Leu Asn Glu Leu Lys Lys Ala Pro Gln Asp 
        275                 280                 285             


Leu Phe Glu His Leu Lys Pro Glu Asp Gln Asp Lys Phe Arg Ile Lys 
    290                 295                 300                 


Ser Thr Thr Gly Asp Asp Ile Leu Leu Arg Arg Ser Glu Asp Arg Phe 
305                 310                 315                 320 


His Phe Phe Ala Met Arg Tyr Ile Asp Glu Lys Arg Leu Phe Asn Asn 
                325                 330                 335     


Ile Arg Phe Gln Val Asn Met Gly Lys Tyr Arg Phe Leu Lys Lys Glu 
            340                 345                 350         


Asp Lys His Cys Ile Asn Asp Glu His Cys Met Arg Ile Leu Gln Lys 
        355                 360                 365             


Asp Ile Asn Gly Phe Gly Arg Leu Gln Glu Met Glu Asp Tyr Arg Cys 
    370                 375                 380                 


Gly Ile Ser Asp Leu Trp Lys Ser Arg Ser Met Ile Lys Pro His Thr 
385                 390                 395                 400 


Asp Ile Thr Arg Asn Asp Pro Asn Ile Leu Pro Tyr Ile Thr Asp Ser 
                405                 410                 415     


Arg Thr Gln Tyr Val Phe Asn Gly Asp Arg Ile Gly Leu Gly Trp Pro 
            420                 425                 430         


Gly Tyr Ser Ser Ser Glu Gly Lys Ser Leu Pro Val Arg Asn Ser Ser 
        435                 440                 445             


Tyr Ile Pro Glu Val Ser Ser Asp Asn Thr Val Glu Cys Ala Gln Pro 
    450                 455                 460                 


Lys Cys Trp Ile Ser Ile Tyr Glu Ile Pro Ala Met Val Phe His Ile 
465                 470                 475                 480 


Leu Leu Asn Gly Asn Ser Gly Val Glu Thr Glu Lys Leu Ile Lys Asp 
                485                 490                 495     


Glu Val Glu Lys Tyr Lys Arg Phe Phe Gln Asp Ile Val Asp Cys Asn 
            500                 505                 510         


Ile Gln Lys Val Lys Cys Lys Asp Ile Lys Asn Pro Thr Pro Val Glu 
        515                 520                 525             


Tyr Lys Pro Ile Glu Asp Lys Tyr Gly Ile Lys Trp Ser Asn Ile Pro 
    530                 535                 540                 


Asp Lys Leu Lys Asp Tyr Leu Val Gly Arg Thr Arg Lys Asn Phe Glu 
545                 550                 555                 560 


Ser Tyr Ala Lys Thr Ile Val Cys Glu Met Ile Glu Lys Asn Lys Arg 
                565                 570                 575     


Ala Ile Glu Arg Phe Lys Glu Asp Ile Lys Lys Val Asn Gly Thr Asp 
            580                 585                 590         


Asn Lys Met Gly Lys Lys Ser Tyr Ile Glu Ile Lys Pro Gly Arg Leu 
        595                 600                 605             


Ala Ala Phe Leu Met Lys Asp Ile Ile Ala Leu Gln Pro Ser Ala Leu 
    610                 615                 620                 


Thr Gly Glu Leu Lys Gly Arg Asp Lys Leu Thr Gly Leu Asn Tyr Ser 
625                 630                 635                 640 


Val Leu Asn Ala Glu Leu Ala Met Tyr Asn Ala Leu Tyr Asp Lys Glu 
                645                 650                 655     


Asn Phe Tyr Arg Leu Lys Val Met Phe Glu Lys Ala Asn Leu Ile Gly 
            660                 665                 670         


Asn Ser Asn Asn Arg His Pro Phe Leu Tyr Lys Val Phe Asp Ser Lys 
        675                 680                 685             


Pro Met Asn Thr Ile Glu Phe Tyr Gln Ser Tyr Met Lys Tyr Arg Leu 
    690                 695                 700                 


Glu Trp Leu Lys Ser Val Leu Ser Lys Lys Asp Phe Lys Ser Val Asn 
705                 710                 715                 720 


Leu Leu Lys Pro Glu Arg Thr Lys Trp Met Asn Arg Asn Thr Glu Phe 
                725                 730                 735     


Tyr Lys Asn Leu Ala Gln Arg Tyr Leu Ser Gln Pro Ile Glu Leu Pro 
            740                 745                 750         


Arg Ser Leu Phe Glu Ser Ser Ile Val Asp Lys Met Ile Glu Ile Cys 
        755                 760                 765             


Ala Asp Asn Asp Asn Leu Gln Glu Leu Lys Lys Lys Leu Ile Arg Tyr 
    770                 775                 780                 


Arg Asn Lys Glu Glu Gly Val Arg Phe Asn Val Thr Tyr Leu Ile Leu 
785                 790                 795                 800 


Lys Tyr His Glu Ser Val Lys Asn Asp Lys Ser Gln Lys Phe Tyr Gly 
                805                 810                 815     


Trp Asp Lys Gly Tyr Lys Val Ile Asp Lys Leu Glu Gly Lys Ser Cys 
            820                 825                 830         


Phe Arg Gln Thr Asn Phe Leu Glu Asn Tyr Asp Phe Lys Gly Lys Thr 
        835                 840                 845             


Asn Glu Tyr Ile Asp Thr Leu Glu Ile Lys Gln Arg Trp Asn Thr Tyr 
    850                 855                 860                 


Lys Lys Ala Ser Asn Glu Glu Lys Glu Ile Glu Leu Lys Lys Ile Glu 
865                 870                 875                 880 


Lys Tyr Arg Lys Glu Leu Asp Glu Asn Glu Arg Thr Leu Arg Arg Leu 
                885                 890                 895     


Lys Val Gln Asp Ile Leu Leu Phe Tyr Leu Ala Lys Asn Ile Ile Gly 
            900                 905                 910         


Ser Gly Val Asp Asn Phe Lys Met Lys Ser Ile Ser Pro Tyr Lys Glu 
        915                 920                 925             


Glu Gly Ile Leu Glu Leu Gln Ile Pro Phe Ser Met Lys Phe Thr Leu 
    930                 935                 940                 


Ser Asp Gly Thr Glu Arg Thr Ile Tyr Gln Glu Ala Ile Lys Ile Lys 
945                 950                 955                 960 


Asn Tyr Gly Asp Phe Phe Cys Tyr Leu Tyr Asp Glu Arg Val Lys Ser 
                965                 970                 975     


Leu Leu Pro Gln Ile Lys Lys Ala Glu Ile Asn Arg Met Glu Leu Asp 
            980                 985                 990         


Arg Glu Leu Met Asn Tyr Asp Leu  Thr Arg Pro Glu Ile  Phe Gly Leu 
        995                 1000                 1005             


Ile Leu  Asp Phe Glu Lys Ala  Val Asn Lys Lys Tyr  Pro Glu Met 
    1010                 1015                 1020             


Thr Lys  Glu Arg His Gly Phe  Thr Asp Leu Leu Asn  Lys Leu Glu 
    1025                 1030                 1035             


Val Leu  Asn Ser Leu Glu Lys  Glu Asn Ile Arg Leu  Val Arg Asn 
    1040                 1045                 1050             


Ala Phe  Ser His Asn Lys Tyr  Pro Asn Ile Lys Asn  Ile Lys Asn 
    1055                 1060                 1065             


Asp Ile  Pro Glu Ile Ala Val  Gly Ile Lys Lys Ser  Phe Ile Lys 
    1070                 1075                 1080             


Asp Thr  Asp Lys Ile Ile Lys  
    1085                 1090 


<210>  2187
<211>  1134
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2187

Met Asn Glu Thr Asp Tyr Leu Ala Lys Arg Leu Glu Tyr Asn Tyr Ala 
1               5                   10                  15      


Ser Ile Glu Asp Lys His Tyr Phe Gly Gly Tyr Phe Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asn Asp Leu Ser Lys Ala Phe Lys Glu Lys Phe Gly Met 
        35                  40                  45              


Lys Pro Lys Ser Cys Ile Leu Asp Phe Phe Thr Gln Asp Lys Ala Ile 
    50                  55                  60                  


Ala Glu Tyr Gln Leu Gly Val Glu Phe Leu Gln Lys Asn Leu Pro Val 
65                  70                  75                  80  


Ile Arg Tyr Leu Tyr Leu Pro Thr Ser His Lys Arg Phe Glu Asn Val 
                85                  90                  95      


Pro Lys Asn Gln Leu Ile Ser Glu Gln Arg Asn Tyr Phe Lys Asn Ser 
            100                 105                 110         


Leu Lys Val Leu Lys Asn Leu Ile Arg Asp Tyr Arg Asn Phe Tyr Thr 
        115                 120                 125             


His His Phe His Lys Pro Ile Pro Val Phe Pro Glu Thr Tyr Lys Leu 
    130                 135                 140                 


Leu Asp Asp Leu Phe Leu Ala Val Ala Asn Asp Val Lys Lys His Arg 
145                 150                 155                 160 


Met Lys Thr Asp Ala Ser Lys Gln Leu Leu Lys Lys Gly Leu Ile Glu 
                165                 170                 175     


Glu Leu Ala Gln Leu Glu Lys Leu Lys Leu Glu Asp Leu Lys Lys Leu 
            180                 185                 190         


Lys Arg Glu Gly Lys Lys Val Asn Leu Asn Asp Lys Glu Ala Ile Thr 
        195                 200                 205             


Asn Ala Ile Leu Asn Asp Ser Phe Ser His Leu Leu Pro Lys Glu Asn 
    210                 215                 220                 


Thr Ile Ser Lys Tyr Tyr Ser Ala Val Pro Thr Glu Asp Ile Asp Thr 
225                 230                 235                 240 


Glu Asn Gly Val Thr Ile Ser Glu Ser Gly Ile Ile Phe Leu Leu Gly 
                245                 250                 255     


Leu Phe Leu Thr Lys Lys Gln Ser Glu Asp Leu Arg Ser Arg Val Lys 
            260                 265                 270         


Gly Phe Lys Ala Lys Leu Ile Val Asn Pro Glu Asn Pro Ile Asn Lys 
        275                 280                 285             


Lys Asn Asn Ser Leu Lys Tyr Met Ala Thr His Trp Val Phe Gly Tyr 
    290                 295                 300                 


Leu Gly Phe Lys Gly Leu Lys Asn Arg Phe Thr Thr Thr Phe Thr Lys 
305                 310                 315                 320 


Asp Thr Leu Leu Ala Gln Ile Val Asp Glu Leu Ser Lys Val Pro Asp 
                325                 330                 335     


Glu Leu Tyr Gln Val Leu Pro Glu Glu Leu Lys Asn Glu Phe Leu Glu 
            340                 345                 350         


Asp Met Asn Glu Tyr Leu Lys Glu Glu Asn Ser Glu Ser Leu Asp Lys 
        355                 360                 365             


Ala Thr Val Ile His Pro Val Ile Arg Lys Arg Tyr Glu Asn Lys Phe 
    370                 375                 380                 


Ala Tyr Phe Ala Leu Arg Phe Leu Asp Glu Phe Val Asp Phe Pro Thr 
385                 390                 395                 400 


Leu Arg Phe Gln Leu His Leu Gly Asn Tyr Val His Asp Lys Arg Glu 
                405                 410                 415     


Lys Pro Ile Glu Gly Thr Lys Tyr Val Thr Glu Arg Ile Val Lys Glu 
            420                 425                 430         


Lys Ile Lys Ala Phe Ala Lys Leu Ser Glu Ala Ala Gln Leu Lys Gln 
        435                 440                 445             


Lys Tyr Phe Glu Glu Lys Glu Asn His Gln Ser Ile Gly Leu Gln Leu 
    450                 455                 460                 


Tyr Pro Asn Pro Ser Tyr Asn Phe Val Gly Asn Asn Ile Pro Ile His 
465                 470                 475                 480 


Leu Asn Leu Asn Glu His Phe Phe Pro Lys Glu Val Lys Ile Val Ala 
                485                 490                 495     


Gly Arg Leu Lys Lys Arg Asn Ser Ser Tyr Lys Ser Asp His Pro Glu 
            500                 505                 510         


Glu Tyr Lys Val Arg Thr Asp Asn Lys Ile Lys Pro Asp Ala Ile Leu 
        515                 520                 525             


Gln Asp Leu Gly Lys Pro Glu Lys Leu Ala Pro Val Ala Met Leu Ser 
    530                 535                 540                 


Leu Asn Glu Leu Pro Ala Leu Leu His Leu Val Leu Thr Lys Lys Thr 
545                 550                 555                 560 


Pro Glu Glu Ile Glu Ile Ile Ile Ala Gln Lys Ile Ala Glu Arg Tyr 
                565                 570                 575     


Asn Val Leu Thr Asn Tyr Lys Ala Gly Asp Asp Ile Ser Lys Gly Gln 
            580                 585                 590         


Ile Thr Lys Asn Leu Leu Lys Ala Lys Gln Lys Lys Glu Val Asn Leu 
        595                 600                 605             


Asp Lys Leu Gln Leu Ala Ile Glu Lys Glu Ile Ala Val Thr Asn Asp 
    610                 615                 620                 


Lys Leu Gln Thr Ile Ala Leu His Ile Lys Glu Arg Asn Asp Pro Lys 
625                 630                 635                 640 


Gln Lys Arg Lys Tyr Val Phe Thr Asn Lys Glu Ile Gly Leu Gln Val 
                645                 650                 655     


Thr Trp Leu Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Gly Ser Arg 
            660                 665                 670         


Gln Asn Trp Arg Gly Gln His His Ser Gln Leu Gln Lys Ser Leu Ala 
        675                 680                 685             


Phe Tyr Asp Ile Gln Pro Lys Glu Pro Leu Ser Leu Leu Glu Glu Val 
    690                 695                 700                 


Trp Asp Phe Lys Asn Glu Ala Tyr Leu Trp Asn Asn Gly Ile Arg Arg 
705                 710                 715                 720 


Ser Phe Asp Lys Arg Asp Phe Ile Ser Phe Tyr Thr Ser Tyr Leu Asn 
                725                 730                 735     


Asn Arg Lys Glu Thr Phe Gln Arg Phe Lys Asp Gln Leu Asn Gly Ile 
            740                 745                 750         


Arg Ser Asn Lys Lys Ile Leu Asp Lys Phe Ile Lys Gln Gln His Leu 
        755                 760                 765             


Trp Asn Leu Phe His Lys Arg Leu Tyr Val Ile Asp Thr Ile Glu Glu 
    770                 775                 780                 


Gln Val Glu Lys Leu Leu Val Lys Pro Met Gln Phe Pro Lys Gly Val 
785                 790                 795                 800 


Phe Asp His Lys Pro Thr Tyr Ile Lys Gly Lys Ser Ile Gln Glu Asn 
                805                 810                 815     


Pro Glu Cys Phe Ala Asp Trp Tyr Val Ala Trp Asn Gln His Thr Asp 
            820                 825                 830         


Tyr Gln Lys Phe Tyr Ser Trp Asp Arg Asp Tyr Lys Ser Ala Tyr Leu 
        835                 840                 845             


Ser Gly Glu Gln Glu Lys Thr Glu Lys Arg Phe Ile Arg Val Gln Gly 
    850                 855                 860                 


Ser Lys Ile Asn Lys Val Lys Gln Gln Asp Val Leu Leu Ala Lys Met 
865                 870                 875                 880 


Ala Ser Ile Ile Phe Asn Glu Leu Tyr Leu Pro Glu Asp Ala Glu His 
                885                 890                 895     


Leu Asp Leu Asn Leu Ser Asp Ile Tyr Lys Thr Gln Thr Glu Arg Lys 
            900                 905                 910         


Ala Glu Ile Glu Ala Ala Leu Ile Gln Ser His Lys Thr Thr Gly Asp 
        915                 920                 925             


Asn Ser Ala Asn Ile Ile Lys Ser Thr Ser Ala Trp Thr Leu Thr Val 
    930                 935                 940                 


Pro Tyr Cys Ser Lys Asn Ile Tyr Glu Pro Gln Val Lys Leu Lys Glu 
945                 950                 955                 960 


Leu Gly Lys Phe Lys Lys Phe Ile Ala Ser Gln Lys Val Gln Thr Leu 
                965                 970                 975     


Phe Glu Tyr Lys Pro Gln Lys Ile Trp Asn Lys Thr Glu Leu Glu Glu 
            980                 985                 990         


Val Leu Glu Leu Lys Ala Asn Ser  Tyr Glu Val Ile Arg  Arg Asp Tyr 
        995                 1000                 1005             


Leu Leu  Lys Ser Ile Gln Glu  Phe Glu Lys Tyr Met  Ile Lys Lys 
    1010                 1015                 1020             


Leu Pro  Thr Leu Ile Asp Thr  Asn Glu His Pro Asn  Phe Asn Lys 
    1025                 1030                 1035             


Tyr Leu  Thr Thr Phe Leu Lys  Ser Leu Glu Leu Val  Ser Glu Glu 
    1040                 1045                 1050             


Asp Ala  Lys Trp Leu Ile Ser  Lys Lys Asp Phe Asp  Thr Thr Pro 
    1055                 1060                 1065             


Ile Asp  Glu Leu Lys Lys Gln  Ser Lys Ile Met Glu  Lys Ala Phe 
    1070                 1075                 1080             


Leu Leu  Val Met Ile Arg Asn  Lys Phe Ser His Asn  Gln Leu Pro 
    1085                 1090                 1095             


Arg Lys  Ile Tyr Tyr Asp Glu  Ile Tyr Lys Asn Val  Pro Asn Ala 
    1100                 1105                 1110             


Val Ser  Ile Asn Phe Asn Glu  Leu Phe Leu Glu Tyr  Thr Asn Gln 
    1115                 1120                 1125             


Thr Ile  Leu Glu Phe Lys 
    1130                 


<210>  2188
<211>  985
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2188

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Asn Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys Gly Tyr 
                165                 170                 175     


Ala Phe Phe Ile Ser Lys Phe Leu Glu Arg Lys Tyr Ser Tyr Leu Phe 
            180                 185                 190         


Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln Tyr Arg 
        195                 200                 205             


Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro Val Glu 
    210                 215                 220                 


Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu Asp Ile 
225                 230                 235                 240 


Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr Leu Glu 
                245                 250                 255     


Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr Asp Ala 
            260                 265                 270         


Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe Arg Ser 
        275                 280                 285             


Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala Asp Phe 
    290                 295                 300                 


Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His Asn Gly 
305                 310                 315                 320 


Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr Ile Asn 
                325                 330                 335     


Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser Ala Lys 
            340                 345                 350         


Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser Thr Asp 
        355                 360                 365             


Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln Ser Thr 
    370                 375                 380                 


Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val Leu Pro 
385                 390                 395                 400 


Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala Lys Met 
                405                 410                 415     


Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala Met Leu 
            420                 425                 430         


Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His Cys Pro 
        435                 440                 445             


Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser Thr Lys 
    450                 455                 460                 


Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg Val Met 
465                 470                 475                 480 


Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu Arg Ile 
                485                 490                 495     


Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile Leu Lys 
            500                 505                 510         


Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp Leu Gln 
        515                 520                 525             


Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn Phe Gln 
    530                 535                 540                 


Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn Asp Leu 
545                 550                 555                 560 


Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn Pro His 
                565                 570                 575     


Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile Glu Phe 
            580                 585                 590         


Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg Ile Gln 
        595                 600                 605             


Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro Leu Arg 
    610                 615                 620                 


Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu Ala Ile 
625                 630                 635                 640 


Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys Leu Lys 
                645                 650                 655     


Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu Lys Ser 
            660                 665                 670         


Pro Ala Leu Asn Val Ser Tyr Leu Ile His Asn Tyr Phe Arg Ala Tyr 
        675                 680                 685             


Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn Tyr Arg 
    690                 695                 700                 


Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser Tyr Leu 
705                 710                 715                 720 


Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro Ser Lys 
                725                 730                 735     


Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp Arg Leu 
            740                 745                 750         


Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile Ile Arg 
        755                 760                 765             


Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys Glu Tyr 
    770                 775                 780                 


Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu Glu Asn 
785                 790                 795                 800 


Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp Leu Asn 
                805                 810                 815     


Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr Gly Lys 
            820                 825                 830         


Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn Lys Val 
        835                 840                 845             


Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val Lys Ile 
    850                 855                 860                 


Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu Glu Ala 
865                 870                 875                 880 


Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala Met Val 
                885                 890                 895     


Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr Tyr Asp 
            900                 905                 910         


Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln Lys Ile 
        915                 920                 925             


Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His Asp Lys 
    930                 935                 940                 


Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val Tyr Ala 
945                 950                 955                 960 


Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile Lys Leu 
                965                 970                 975     


Glu Asp Leu Ser Asn Asp Ser Ser Ala 
            980                 985 


<210>  2189
<211>  1121
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2189

Val Lys Lys Lys Glu Glu Glu Thr Pro Val Val Ser Thr Tyr Asn Lys 
1               5                   10                  15      


Asp Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Val Tyr Ile Thr Ile Asn His Ile Asn Lys Leu Leu Glu Ile Arg Glu 
        35                  40                  45              


Ile Asp Asn Asp Glu Lys Val Leu Asp Ile Lys Ala Leu Trp Gln Lys 
    50                  55                  60                  


Val Asn Lys Asp Leu Asn Gln Lys Ala Arg Leu Arg Glu Leu Met Thr 
65                  70                  75                  80  


Lys His Phe Pro Phe Leu Glu Thr Ala Ile Tyr Ser Lys Asn Lys Glu 
                85                  90                  95      


Asp Lys Glu Glu Val Lys Gln Glu Lys Gln Ala Thr Ala Gln Ser Phe 
            100                 105                 110         


Lys Ser Leu Glu His Cys Leu Phe Leu Phe Leu Glu Lys Leu Gln Glu 
        115                 120                 125             


Ala Arg Asn Tyr Tyr Ser His Tyr Lys Tyr Ser Glu Ser Thr Lys Glu 
    130                 135                 140                 


Pro Val Leu Glu Lys Glu Leu Leu Lys Lys Met Tyr Asn Ile Phe Asp 
145                 150                 155                 160 


Asn Asn Ile Gln Leu Val Ile Lys Asp Tyr Gln His Asn Lys Asp Ile 
                165                 170                 175     


Asn Pro Asp Glu Asp Phe Lys His Leu Asp Arg Thr Glu Lys Glu Phe 
            180                 185                 190         


Asn Tyr Tyr Phe Thr Gln Asp Lys Lys Gly Lys Ile Thr Glu Ser Gly 
        195                 200                 205             


Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp 
    210                 215                 220                 


Met Gln Gln Lys Leu Arg Gly Phe Lys Asp Asn Arg Glu Asn Asn Lys 
225                 230                 235                 240 


Gln Met Thr His Glu Val Phe Cys Arg Ser Arg Met Leu Leu Pro Lys 
                245                 250                 255     


Leu Arg Leu Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met 
            260                 265                 270         


Leu Asn Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Lys 
        275                 280                 285             


Gly Glu Asp Arg Lys Lys Phe Glu Val Pro Phe Asp Ser Thr Asp Glu 
    290                 295                 300                 


Asp Tyr Asp Ala Glu Gln Asp Pro Phe Lys Asn Thr Leu Ile Arg His 
305                 310                 315                 320 


Gln Asp Arg Phe Pro Tyr Phe Ile Leu Arg Tyr Phe Asp Tyr Asn Glu 
                325                 330                 335     


Ile Phe Lys Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe 
            340                 345                 350         


Ser Ile Tyr Lys Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg His Leu 
        355                 360                 365             


Thr His Lys Leu Tyr Gly Phe Glu Arg Ile Gln Glu Phe Thr Lys Gln 
    370                 375                 380                 


His Arg Pro Asp Asp Trp Lys Ala Ile Val Lys Asp Phe Asp Thr Tyr 
385                 390                 395                 400 


Glu Thr Ser Glu Glu Pro Tyr Ile Ser Glu Thr Thr Pro His Tyr His 
                405                 410                 415     


Leu Glu Asn Gln Lys Ile Gly Ile Arg Phe Lys Asn Asp Asn Asp Lys 
            420                 425                 430         


Ile Trp Pro Ser Leu Glu Thr Asn Gly Glu Asn Asn Glu Lys Ser Lys 
        435                 440                 445             


Tyr Lys Leu Asp Lys Gln Tyr Gln Ala Glu Ala Phe Leu Ser Val His 
    450                 455                 460                 


Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Lys Lys Glu Glu 
465                 470                 475                 480 


Pro Asn Asn Asp Lys Lys Asn Ala Ser Arg Val Glu Gly Phe Ile Lys 
                485                 490                 495     


Arg Glu Ile Arg Asp Ile Phe Lys Leu Tyr Asp Ala Phe Ala Asn Asp 
            500                 505                 510         


Glu Ile Asn Asn Ile Asp Asp Leu Lys Lys Tyr Cys Lys Asp Lys Asn 
        515                 520                 525             


Val Glu Ile Arg His Leu Pro Lys Gln Leu Ile Thr Ile Leu Glu Ser 
    530                 535                 540                 


Lys Pro Lys Asp Met Ala Lys Glu Ala Lys Arg Lys Gln Lys Glu Met 
545                 550                 555                 560 


Val Lys Asp Thr Lys Lys Leu Leu Ala Thr Leu Glu Lys Gln Thr Gln 
                565                 570                 575     


Lys Glu Lys Glu Asp Asp Gly Arg Asn Val Lys Leu Leu Lys Ser Gly 
            580                 585                 590         


Glu Ile Ala Arg Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Val 
        595                 600                 605             


Gln Lys Asp Asn Glu Gly Asn Pro Leu Asn Asn Ser Lys Ala Asn Ser 
    610                 615                 620                 


Thr Glu Tyr Gln Met Leu Gln Arg Ser Leu Ala Leu Tyr Asn Lys Glu 
625                 630                 635                 640 


Glu Lys Pro Thr Arg Tyr Phe Arg Gln Val Asn Leu Ile Asn Ser Ser 
                645                 650                 655     


Asn Pro His Pro Phe Leu Lys Trp Thr Lys Trp Glu Glu Cys Asn Asn 
            660                 665                 670         


Ile Leu Ser Phe Tyr Arg Ser Tyr Leu Thr Lys Lys Ile Glu Phe Leu 
        675                 680                 685             


Asn Lys Leu Lys Pro Glu Asp Trp Glu Lys Asn Gln Tyr Phe Leu Lys 
    690                 695                 700                 


Leu Lys Glu Pro Lys Thr Asn Arg Glu Thr Leu Val Gln Gly Trp Lys 
705                 710                 715                 720 


Asn Gly Phe Asn Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg Glu 
                725                 730                 735     


Trp Phe Lys Arg His Gln Asn Asp Ser Lys Glu Tyr Glu Lys Val Glu 
            740                 745                 750         


Ala Leu Lys Arg Val Gly Leu Val Thr Lys Val Ile Pro Leu Phe Phe 
        755                 760                 765             


Lys Glu Glu Tyr Phe Lys Glu Asp Ala Gln Lys Glu Ile Asn Asp Trp 
    770                 775                 780                 


Val Gln Pro Phe Tyr Ser Phe Pro Tyr Asn Val Gly Asn Ile His Lys 
785                 790                 795                 800 


Pro Lys Glu Glu Asp Phe Leu His Arg Glu Glu Arg Ile Glu Leu Trp 
                805                 810                 815     


Asp Lys Lys Lys Asp Lys Phe Lys Gly Tyr Lys Glu Lys Ile Lys Ser 
            820                 825                 830         


Lys Lys Leu Thr Glu Lys Glu Lys Glu Glu Phe Arg Ser Tyr Leu Glu 
        835                 840                 845             


Phe Gln Ser Trp Asn Lys Phe Glu Arg Glu Leu Arg Leu Val Arg Asn 
    850                 855                 860                 


Gln Asp Ile Val Thr Trp Leu Leu Cys Lys Glu Leu Ile Asp Lys Leu 
865                 870                 875                 880 


Lys Ile Asp Glu Leu Asn Ile Asp Glu Leu Lys Lys Leu His Leu Asn 
                885                 890                 895     


Asn Ile Asp Thr Asp Thr Ala Lys Lys Glu Lys Asn Asn Ile Leu Asn 
            900                 905                 910         


Arg Val Met Pro Met Glu Leu Pro Val Thr Val Tyr Lys Val Asn Lys 
        915                 920                 925             


Ala Gly Asn Ile Ile Lys Asn Lys Pro Leu His Thr Ile Tyr Ile Lys 
    930                 935                 940                 


Glu Ser Lys Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu Val 
945                 950                 955                 960 


Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Val Lys Thr Asn Ser 
                965                 970                 975     


Glu Ala Glu Ser Lys Arg Asn Pro Ile Ser Lys Leu Arg Val Glu His 
            980                 985                 990         


Glu Leu Arg Glu Tyr Gln Lys Ala  Arg Ile Glu Ile Ile  Lys Asp Met 
        995                 1000                 1005             


Leu Ala  Leu Glu Lys Thr Leu  Ile Asp Asn Tyr Asn  Ser Leu Asp 
    1010                 1015                 1020             


Thr Asp  Asn Phe His Asn Met  Leu Thr Gly Trp Leu  Glu Leu Lys 
    1025                 1030                 1035             


Gly Glu  Val Asn Lys Ala Lys  Phe Asn Asn Asp Val  Lys Leu Leu 
    1040                 1045                 1050             


Thr Ala  Val Arg Asn Ala Phe  Ser His Asn Gln Tyr  Pro Met Tyr 
    1055                 1060                 1065             


Asp Glu  Asn Leu Phe Val Asn  Ile Glu Arg Phe Ser  Leu Ser Ser 
    1070                 1075                 1080             


Ser Lys  Ile Leu Glu Ser Lys  Gly Leu Ser Ile Ala  Val Lys Leu 
    1085                 1090                 1095             


Lys Glu  Glu Val Ser Lys Ile  Val Lys Lys Ile Gln  Glu Glu Glu 
    1100                 1105                 1110             


Asp Gly  Lys Lys Glu Lys Glu  Thr 
    1115                 1120     


<210>  2190
<211>  1134
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2190

Met Asn Glu Thr Asp Tyr Leu Ala Lys Arg Leu Glu Tyr Asn Tyr Ala 
1               5                   10                  15      


Ser Ile Glu Asp Lys His Tyr Phe Gly Gly Tyr Phe Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asn Asp Leu Ser Lys Ala Phe Lys Glu Lys Phe Gly Met 
        35                  40                  45              


Lys Pro Lys Ser Cys Ile Leu Asp Phe Phe Thr Gln Asp Lys Ala Ile 
    50                  55                  60                  


Ala Glu Tyr Gln Leu Gly Val Glu Phe Leu Gln Lys Asn Leu Pro Val 
65                  70                  75                  80  


Ile Arg Tyr Leu Tyr Leu Pro Thr Ser His Lys Arg Phe Glu Asn Val 
                85                  90                  95      


Pro Lys Asn Gln Leu Ile Ser Glu Gln Arg Asn Tyr Phe Lys Asn Ser 
            100                 105                 110         


Leu Lys Val Leu Lys Asn Leu Ile Arg Asp Tyr Arg Asn Phe Tyr Thr 
        115                 120                 125             


His His Phe His Lys Pro Ile Pro Val Phe Pro Glu Thr Tyr Lys Leu 
    130                 135                 140                 


Leu Asp Asp Leu Phe Leu Ala Val Ala Asn Asp Val Lys Lys His Arg 
145                 150                 155                 160 


Met Lys Thr Asp Ala Ser Lys Gln Leu Leu Lys Lys Gly Leu Ile Glu 
                165                 170                 175     


Glu Leu Ala Gln Leu Glu Lys Leu Lys Leu Glu Asp Leu Lys Lys Leu 
            180                 185                 190         


Lys Arg Glu Gly Lys Lys Val Asn Leu Asn Asp Lys Glu Ala Ile Thr 
        195                 200                 205             


Asn Ala Ile Leu Asn Asp Ser Phe Ser His Leu Leu Pro Lys Glu Asn 
    210                 215                 220                 


Thr Ile Ser Lys Tyr Tyr Ser Ala Val Pro Thr Glu Asp Ile Asp Thr 
225                 230                 235                 240 


Glu Asn Gly Val Thr Ile Ser Glu Ser Gly Ile Ile Phe Leu Leu Gly 
                245                 250                 255     


Leu Phe Leu Thr Lys Lys Gln Ser Glu Asp Leu Arg Ser Arg Val Lys 
            260                 265                 270         


Gly Phe Lys Ala Lys Leu Ile Val Asn Pro Glu Asn Pro Ile Asn Lys 
        275                 280                 285             


Lys Asn Asn Ser Leu Lys Tyr Met Ala Thr His Trp Val Phe Gly Tyr 
    290                 295                 300                 


Leu Gly Phe Lys Gly Leu Lys Asn Arg Phe Thr Thr Thr Phe Thr Lys 
305                 310                 315                 320 


Asp Thr Leu Leu Ala Gln Ile Val Asp Glu Leu Ser Lys Val Pro Asp 
                325                 330                 335     


Glu Leu Tyr Gln Val Leu Pro Glu Glu Leu Lys Asn Glu Phe Leu Glu 
            340                 345                 350         


Asp Met Asn Glu Tyr Leu Lys Glu Glu Asn Ser Glu Ser Leu Asp Lys 
        355                 360                 365             


Ala Thr Val Ile His Pro Val Ile Arg Lys Arg Tyr Glu Asn Lys Phe 
    370                 375                 380                 


Ala Tyr Phe Ala Leu Arg Phe Leu Asp Glu Phe Val Asp Phe Pro Thr 
385                 390                 395                 400 


Leu Arg Phe Gln Leu His Leu Gly Asn Tyr Val His Asp Lys Arg Glu 
                405                 410                 415     


Lys Pro Ile Glu Gly Thr Lys Tyr Val Thr Glu Arg Ile Val Lys Glu 
            420                 425                 430         


Lys Ile Lys Ala Phe Ala Lys Leu Ser Glu Ala Ala Gln Leu Lys Gln 
        435                 440                 445             


Lys Tyr Phe Glu Glu Lys Glu Asn His Gln Ser Ile Gly Leu Gln Leu 
    450                 455                 460                 


Tyr Pro Asn Pro Ser Tyr Asn Phe Val Gly Asn Asn Ile Pro Ile His 
465                 470                 475                 480 


Leu Asn Leu Asn Glu His Phe Phe Pro Lys Glu Val Lys Ile Val Ala 
                485                 490                 495     


Gly Arg Leu Lys Lys Arg Asn Ser Ser Tyr Lys Ser Asp His Pro Glu 
            500                 505                 510         


Glu Tyr Lys Val Arg Thr Asp Asn Lys Ile Lys Pro Asp Ala Ile Leu 
        515                 520                 525             


Gln Asp Leu Gly Lys Pro Glu Lys Leu Ala Pro Val Ala Met Leu Ser 
    530                 535                 540                 


Leu Asn Glu Leu Pro Ala Leu Leu His Leu Val Leu Thr Lys Lys Thr 
545                 550                 555                 560 


Pro Glu Glu Ile Glu Ile Ile Ile Ala Gln Lys Ile Ala Glu Arg Tyr 
                565                 570                 575     


Asn Val Leu Thr Asn Tyr Lys Ala Gly Asp Asp Ile Ser Lys Gly Gln 
            580                 585                 590         


Ile Thr Lys Asn Leu Leu Lys Ala Lys Gln Lys Lys Glu Val Asn Leu 
        595                 600                 605             


Asp Lys Leu Gln Leu Ala Ile Glu Lys Glu Ile Ala Val Thr Asn Asp 
    610                 615                 620                 


Lys Leu Gln Thr Ile Ala Leu His Ile Lys Glu Arg Asn Asp Pro Lys 
625                 630                 635                 640 


Gln Lys Arg Lys Tyr Val Phe Thr Asn Lys Glu Ile Gly Leu Gln Val 
                645                 650                 655     


Thr Trp Leu Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Gly Ser Arg 
            660                 665                 670         


Gln Asn Trp Arg Gly Gln His His Ser Gln Leu Gln Lys Ser Leu Ala 
        675                 680                 685             


Phe Tyr Asp Ile Gln Pro Lys Glu Pro Leu Ser Leu Leu Glu Glu Val 
    690                 695                 700                 


Trp Asp Phe Lys Asn Glu Ala Tyr Leu Trp Asn Asn Gly Ile Arg Arg 
705                 710                 715                 720 


Ser Phe Asp Lys Arg Asp Phe Ile Ser Phe Tyr Thr Ser Tyr Leu Asn 
                725                 730                 735     


Asn Arg Lys Glu Thr Phe Gln Arg Phe Lys Asp Gln Leu Asn Gly Ile 
            740                 745                 750         


Arg Ser Asn Lys Lys Ile Leu Asp Lys Phe Ile Lys Gln Gln His Leu 
        755                 760                 765             


Trp Asn Leu Phe His Lys Arg Leu Tyr Val Ile Asp Thr Ile Glu Glu 
    770                 775                 780                 


Gln Val Glu Lys Leu Leu Val Lys Pro Met Gln Phe Pro Lys Gly Val 
785                 790                 795                 800 


Phe Asp His Lys Pro Thr Tyr Ile Lys Gly Lys Ser Ile Gln Glu Asn 
                805                 810                 815     


Pro Glu Cys Phe Ala Asp Trp Tyr Val Ala Trp Asn Gln His Thr Asp 
            820                 825                 830         


Tyr Gln Lys Phe Tyr Ser Trp Asp Arg Asp Tyr Lys Ser Ala Tyr Leu 
        835                 840                 845             


Ser Gly Glu Gln Glu Lys Thr Glu Lys Arg Phe Ile Arg Val Gln Gly 
    850                 855                 860                 


Ser Lys Ile Asn Lys Val Lys Gln Gln Asp Val Leu Leu Ala Lys Met 
865                 870                 875                 880 


Ala Ser Ile Ile Phe Asn Glu Leu Tyr Leu Pro Glu Asp Ala Glu His 
                885                 890                 895     


Leu Asp Leu Asn Leu Ser Asp Ile Tyr Lys Thr Gln Thr Glu Arg Lys 
            900                 905                 910         


Ala Glu Ile Glu Ala Ala Leu Ile Gln Ser His Lys Thr Thr Gly Asp 
        915                 920                 925             


Asn Ser Ala Asn Ile Ile Lys Ser Thr Ser Ala Trp Thr Leu Thr Val 
    930                 935                 940                 


Pro Tyr Cys Ser Lys Asn Ile Tyr Glu Pro Gln Val Lys Leu Lys Glu 
945                 950                 955                 960 


Leu Gly Lys Phe Lys Lys Phe Ile Ala Ser Gln Lys Val Gln Thr Leu 
                965                 970                 975     


Phe Glu Tyr Lys Pro Gln Lys Ile Trp Asn Lys Thr Glu Leu Glu Glu 
            980                 985                 990         


Val Leu Glu Leu Lys Ala Asn Ser  Tyr Glu Val Ile Arg  Arg Asp Tyr 
        995                 1000                 1005             


Leu Leu  Lys Ser Ile Gln Glu  Phe Glu Lys Tyr Met  Ile Lys Lys 
    1010                 1015                 1020             


Leu Pro  Thr Leu Ile Asp Thr  Asn Glu His Pro Asn  Phe Asn Lys 
    1025                 1030                 1035             


Tyr Leu  Thr Thr Phe Leu Lys  Ser Leu Glu Leu Val  Ser Glu Glu 
    1040                 1045                 1050             


Asp Ala  Lys Trp Leu Ile Ser  Lys Lys Asp Phe Asp  Thr Thr Pro 
    1055                 1060                 1065             


Ile Asp  Glu Leu Lys Lys Gln  Ser Lys Ile Met Glu  Lys Ala Phe 
    1070                 1075                 1080             


Leu Leu  Val Met Ile Arg Asn  Lys Phe Ser His Asn  Gln Leu Pro 
    1085                 1090                 1095             


Arg Lys  Ile Tyr Tyr Asp Glu  Ile Tyr Lys Asn Val  Pro Asn Ala 
    1100                 1105                 1110             


Val Ser  Ile Asn Phe Asn Glu  Leu Phe Leu Glu Tyr  Thr Asn Gln 
    1115                 1120                 1125             


Thr Ile  Leu Glu Phe Lys 
    1130                 


<210>  2191
<211>  1125
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2191

Val Lys Met Glu Asp Asp Lys Lys Thr Thr Glu Ser Thr Asn Met Leu 
1               5                   10                  15      


Asp Asn Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Val Tyr Ile Thr Val Asn His Ile Asn Lys Val Leu Glu Leu Lys Asn 
        35                  40                  45              


Lys Lys Asp Gln Asp Ile Ile Ile Asp Asn Asp Gln Asp Ile Leu Ala 
    50                  55                  60                  


Ile Lys Thr His Trp Glu Lys Val Asn Gly Asp Leu Asn Lys Thr Glu 
65                  70                  75                  80  


Arg Leu Arg Glu Leu Met Thr Lys His Phe Pro Phe Leu Glu Thr Ala 
                85                  90                  95      


Ile Tyr Thr Lys Asn Lys Glu Asp Lys Glu Glu Val Lys Gln Glu Lys 
            100                 105                 110         


Gln Ala Glu Ala Gln Ser Leu Glu Ser Leu Lys Asp Cys Leu Phe Leu 
        115                 120                 125             


Phe Leu Glu Lys Leu Gln Glu Ala Arg Asn Tyr Tyr Ser His Tyr Lys 
    130                 135                 140                 


Tyr Ser Glu Ser Thr Lys Glu Pro Met Leu Glu Glu Gly Leu Leu Glu 
145                 150                 155                 160 


Lys Met Tyr Asn Ile Phe Asp Asp Asn Ile Gln Leu Val Ile Lys Asp 
                165                 170                 175     


Tyr Gln His Asn Lys Asp Ile Asn Pro Asp Glu Asp Phe Lys His Leu 
            180                 185                 190         


Asp Arg Lys Gly Gln Phe Lys Tyr Ser Phe Ala Asp Asn Glu Gly Asn 
        195                 200                 205             


Ile Thr Glu Ser Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys 
    210                 215                 220                 


Lys Asp Ala Ile Trp Met Gln Gln Lys Leu Thr Gly Phe Lys Asp Asn 
225                 230                 235                 240 


Arg Glu Ser Lys Lys Lys Met Thr His Glu Val Phe Cys Arg Arg Arg 
                245                 250                 255     


Met Leu Leu Pro Lys Leu Arg Leu Glu Ser Thr Gln Thr Gln Asp Trp 
            260                 265                 270         


Ile Leu Leu Asp Met Leu Asn Glu Leu Ile Arg Cys Pro Lys Ser Leu 
        275                 280                 285             


Tyr Glu Arg Leu Gln Gly Glu Tyr Arg Lys Lys Phe Asn Val Pro Phe 
    290                 295                 300                 


Asp Ser Ala Asp Glu Asp Tyr Asp Ala Glu Gln Glu Pro Phe Lys Asn 
305                 310                 315                 320 


Thr Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr 
                325                 330                 335     


Phe Asp Tyr Asn Glu Ile Phe Thr Asn Leu Arg Phe Gln Ile Asp Leu 
            340                 345                 350         


Gly Thr Tyr His Phe Ser Ile Tyr Lys Lys Leu Ile Gly Gly Gln Lys 
        355                 360                 365             


Glu Asp Arg His Leu Thr His Lys Leu Tyr Gly Phe Glu Arg Ile Gln 
    370                 375                 380                 


Glu Phe Ala Lys Gln Asn Arg Pro Asp Glu Trp Lys Ala Leu Val Lys 
385                 390                 395                 400 


Asp Leu Asp Thr Tyr Glu Thr Ser Asn Glu Arg Tyr Ile Ser Glu Thr 
                405                 410                 415     


Thr Pro His Tyr His Leu Glu Asn Gln Lys Ile Gly Ile Arg Phe Arg 
            420                 425                 430         


Asn Gly Asn Lys Glu Ile Trp Pro Ser Leu Lys Thr Asn Gly Glu Asn 
        435                 440                 445             


Asn Glu Lys Ser Lys Tyr Lys Leu Asp Lys Pro Tyr Gln Ala Glu Ala 
    450                 455                 460                 


Phe Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu 
465                 470                 475                 480 


Leu Lys Lys Glu Glu Pro Asn Asn Asp Lys Lys Asn Ala Ser Ile Val 
                485                 490                 495     


Glu Gly Phe Ile Lys Arg Glu Ile Arg Asp Met Tyr Lys Leu Tyr Asp 
            500                 505                 510         


Ala Phe Ala Asn Gly Glu Ile Asn Asn Ile Gly Asp Leu Glu Lys Tyr 
        515                 520                 525             


Cys Glu Asp Lys Gly Ile Pro Lys Arg His Leu Pro Lys Gln Met Val 
    530                 535                 540                 


Ala Ile Leu Tyr Asp Glu Pro Lys Asp Met Val Lys Glu Ala Lys Arg 
545                 550                 555                 560 


Lys Gln Lys Glu Met Val Lys Asp Thr Lys Lys Leu Leu Ala Thr Leu 
                565                 570                 575     


Glu Lys Gln Thr Gln Glu Glu Ile Glu Asp Gly Gly Arg Asn Ile Arg 
            580                 585                 590         


Leu Leu Lys Ser Gly Glu Ile Ala Arg Trp Leu Val Asn Asp Met Met 
        595                 600                 605             


Arg Phe Gln Pro Val Gln Lys Asp Asn Glu Gly Asn Pro Leu Asn Asn 
    610                 615                 620                 


Ser Lys Ala Asn Ser Thr Glu Tyr Gln Met Leu Gln Arg Ser Leu Ala 
625                 630                 635                 640 


Leu Tyr Asn Lys Glu Glu Lys Pro Thr Arg Tyr Phe Arg Gln Val Asn 
                645                 650                 655     


Leu Ile Asn Ser Ser Asn Pro His Pro Phe Leu Lys Trp Thr Lys Trp 
            660                 665                 670         


Glu Glu Cys Asn Asn Ile Leu Ser Phe Tyr Arg Asn Tyr Leu Thr Lys 
        675                 680                 685             


Lys Ile Glu Phe Leu Asn Lys Leu Lys Pro Glu Asp Trp Glu Lys Asn 
    690                 695                 700                 


Gln Tyr Phe Leu Lys Leu Lys Glu Pro Lys Thr Asn Arg Glu Thr Leu 
705                 710                 715                 720 


Val Gln Gly Trp Lys Asn Gly Phe Asn Leu Pro Arg Gly Ile Phe Thr 
                725                 730                 735     


Glu Pro Ile Arg Glu Trp Phe Lys Arg His Gln Asn Asp Ser Lys Glu 
            740                 745                 750         


Tyr Glu Lys Val Glu Ala Leu Lys Arg Val Gly Leu Val Thr Lys Val 
        755                 760                 765             


Ile Pro Leu Phe Phe Lys Glu Glu Tyr Phe Lys Glu Asp Ala Gln Lys 
    770                 775                 780                 


Glu Ile Asn Asn Cys Val Gln Pro Phe Tyr Ser Phe Pro Tyr Asn Val 
785                 790                 795                 800 


Gly Asn Ile His Lys Pro Asp Glu Lys Asp Phe Leu Pro Ser Glu Glu 
                805                 810                 815     


Arg Lys Lys Leu Trp Gly Asp Lys Lys Asp Lys Phe Lys Gly Tyr Lys 
            820                 825                 830         


Ala Lys Val Lys Ser Lys Lys Leu Thr Asp Lys Glu Lys Glu Glu Tyr 
        835                 840                 845             


Arg Ser Tyr Leu Glu Phe Gln Ser Trp Asn Lys Phe Glu Arg Glu Leu 
    850                 855                 860                 


Arg Leu Val Arg Asn Gln Asp Ile Val Thr Trp Leu Leu Cys Thr Glu 
865                 870                 875                 880 


Leu Ile Asp Lys Met Lys Val Glu Gly Leu Asn Val Glu Glu Leu Gln 
                885                 890                 895     


Lys Leu Arg Leu Lys Asp Ile Asp Thr Asp Thr Ala Lys Gln Glu Lys 
            900                 905                 910         


Asn Asn Ile Leu Asn Arg Ile Met Pro Met Gln Leu Pro Val Thr Val 
        915                 920                 925             


Tyr Glu Ile Asp Asp Ser His Asn Ile Val Lys Asp Arg Pro Leu His 
    930                 935                 940                 


Thr Val Tyr Ile Glu Glu Thr Lys Thr Lys Leu Leu Lys Gln Gly Asn 
945                 950                 955                 960 


Phe Lys Ala Leu Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe 
                965                 970                 975     


Val Asp Thr Ser Ser Lys Ala Glu Leu Lys Asp Lys Pro Ile Ser Lys 
            980                 985                 990         


Ser Val Val Glu Tyr Glu Leu Gly  Glu Tyr Gln Asn Ala  Arg Ile Glu 
        995                 1000                 1005             


Thr Ile  Lys Asp Met Leu Leu  Leu Glu Lys Thr Leu  Ile Lys Lys 
    1010                 1015                 1020             


Tyr Glu  Lys Leu Pro Thr Asp  Asn Phe Ser Asp Met  Leu Asn Gly 
    1025                 1030                 1035             


Trp Leu  Glu Gly Lys Asp Glu  Ser Asp Lys Ala Arg  Phe Gln Asn 
    1040                 1045                 1050             


Asp Val  Lys Leu Leu Val Ala  Val Arg Asn Ala Phe  Ser His Asn 
    1055                 1060                 1065             


Gln Tyr  Pro Met Arg Asn Arg  Ile Ala Phe Ala Asn  Ile Asn Pro 
    1070                 1075                 1080             


Phe Ser  Leu Ser Ser Ala Asp  Ile Ser Glu Glu Lys  Lys Leu Asp 
    1085                 1090                 1095             


Ile Ala  Asn Gln Leu Lys Asp  Lys Thr His Lys Ile  Ile Lys Lys 
    1100                 1105                 1110             


Ile Ile  Glu Ile Glu Lys Pro  Ile Glu Thr Lys Glu  
    1115                 1120                 1125 


<210>  2192
<211>  1137
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2192

Met Glu Asn Asn Asn Leu Gly Asn Gly Ile Val Tyr Asp Tyr Ala Ile 
1               5                   10                  15      


Ile Ala Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Lys Asp 
            20                  25                  30          


Asn Ile Asp Ala Val Phe Lys Ala Tyr Glu Asp Arg Phe Gly Glu Asn 
        35                  40                  45              


Val Pro Asp Met Lys Ile Glu Asn Leu Ser Tyr Gln Asp Tyr Gln Asn 
    50                  55                  60                  


Arg Ile Asp Phe Leu Lys Tyr Tyr Phe Pro Val Ile Asn Tyr Leu Asp 
65                  70                  75                  80  


Leu Pro Val Ser Asp Lys Glu Phe Glu Asn Ile Arg Asp Lys Glu Pro 
                85                  90                  95      


Lys Arg Arg Lys Tyr Phe Arg Glu Asn Phe Lys Thr Leu Tyr Lys Ala 
            100                 105                 110         


Val Ser Ala Leu Arg His Phe Tyr Thr His Tyr Tyr His Glu Pro Leu 
        115                 120                 125             


Ser Phe Glu Met Asn Leu Phe Ser Leu Leu Asp Lys Ile Phe Ile Ser 
    130                 135                 140                 


Val Ile Glu Asp Ile Lys Lys Glu Lys Lys Asn Asp Asn Lys Thr Arg 
145                 150                 155                 160 


Pro Leu Leu Asn Arg Asn Leu Lys Glu Glu Leu Lys Cys Leu Met Ala 
                165                 170                 175     


Leu Lys Lys Gln Glu Leu Lys Glu Lys Gln Lys Ser Gln Lys Asn Ile 
            180                 185                 190         


Ser Leu Asp Glu Val Ser Ile Gln Asn Ala Val Phe Asn Asp Ala Phe 
        195                 200                 205             


Ser Gln Phe Phe Asn Lys Glu Lys Lys Ile Ser Arg Phe Tyr Gln Ala 
    210                 215                 220                 


Glu Asn Thr Asp Thr Asp Ile Glu Asn Lys Leu Asn Ile Ser Gln Thr 
225                 230                 235                 240 


Gly Leu Leu Phe Leu Leu Gly Met Phe Leu Thr Lys Lys Gln Ser Glu 
                245                 250                 255     


Asp Leu Arg Ser Arg Ile Arg Arg Phe Lys Asn Lys Ile Ile Lys Asn 
            260                 265                 270         


Gln Asp His Pro Val Ser Lys Gln Asn Asn Ser Leu Lys Tyr Met Ser 
        275                 280                 285             


Thr Gln Trp Val Phe Gly Tyr Leu Ala Phe Lys Gly Leu Lys Ser Thr 
    290                 295                 300                 


Leu Asn Thr Thr Phe Met Gln Glu Thr Leu Leu Thr Gln Ile Val Asp 
305                 310                 315                 320 


Glu Leu Ser Lys Val Pro Asn Glu Ile Tyr Arg Asn Leu Ser Gln Glu 
                325                 330                 335     


Gln Gln Gln Leu Phe Ile Glu Asp Met Asn Glu Tyr Val Gln Asp Gly 
            340                 345                 350         


Asn Asn Val Lys Ser Leu Glu Asp Ala Ile Val Ile His Pro Val Ile 
        355                 360                 365             


Arg Lys Arg Tyr Glu Asp Lys Phe Pro Tyr Phe Val Ile Arg Tyr Leu 
    370                 375                 380                 


Asp Glu Tyr Ala Gly Phe Pro Thr Leu Lys Phe Gln Ile Gln Leu Gly 
385                 390                 395                 400 


Asn Tyr Val His Asp Lys Arg Thr Lys Lys Ile Gln Gly Thr Val Tyr 
                405                 410                 415     


Ser Thr Glu Arg Val Val Lys Glu Lys Ile Thr Val Phe Gly Lys Leu 
            420                 425                 430         


Ser Glu Ile Thr Ala Leu Lys Asp Asn Tyr Leu Lys Lys Arg Thr Gln 
        435                 440                 445             


Asn Asn Glu Glu Asn Arg Gly Trp Glu Ile Tyr Pro Asn Pro Ser Tyr 
    450                 455                 460                 


Asn Phe Thr Gly Asn Asn Ile Pro Ile Tyr Leu Asp Leu Glu Ser Ser 
465                 470                 475                 480 


Asn Val Pro Gly Ala Lys Gln Leu Tyr Gly Asn Ile Gln Lys Gln Cys 
                485                 490                 495     


Ala Asp Leu Arg Lys Lys Asn Ile Glu Asn Gln Asp Gln Thr Glu Arg 
            500                 505                 510         


Ala Asp Lys Ala Thr Lys His Asp Ile Val Lys Leu Ile Asp Ser Lys 
        515                 520                 525             


Lys Ile Val Ile Lys Lys Pro Thr Ala Phe Leu Ser Leu Asn Glu Leu 
    530                 535                 540                 


Ser Gly Leu Leu Tyr Glu Leu Leu Val Asn Lys Lys Asn Gly Lys Gln 
545                 550                 555                 560 


Ile Glu Asp Ile Leu Ile Lys Lys Leu Ile Glu His Tyr Asp Thr Ile 
                565                 570                 575     


Ser Glu Phe Ser Thr Glu Asn Pro Leu Pro Thr Ser Gln Ile Thr Lys 
            580                 585                 590         


Lys Leu Leu Lys Ser Asn Ser Glu Ser Gln Trp Asn Thr Gly Lys Leu 
        595                 600                 605             


Met Arg Asp Ile Glu Arg Glu Ile Ala Val Thr Glu His Lys Leu Asn 
    610                 615                 620                 


Leu Ile Lys Asp Lys Arg Asp Ser Leu Ser Arg Tyr Asn Leu Lys Glu 
625                 630                 635                 640 


Lys Ile Arg Lys Pro Val Phe Ser Asn Arg Ala Ala Gly Lys Glu Ala 
                645                 650                 655     


Val Trp Ile Ala Glu Asp Leu Val Arg Phe Met Pro Lys Ala Val Arg 
            660                 665                 670         


Lys Asn Trp Lys Gly Tyr His His Ser Gln Leu Gln Gln Ser Leu Ala 
        675                 680                 685             


Phe Tyr Glu Gln Arg Pro Asn Glu Ala Val Asn Leu Val Lys Gln Tyr 
    690                 695                 700                 


Trp Asn Leu Asn Asp Thr Arg Tyr Cys Trp Asn Glu Gly Ile Lys Lys 
705                 710                 715                 720 


Ser Phe Glu Arg Ser Glu Phe Asp Leu Phe Tyr Glu Ala Tyr Leu Lys 
                725                 730                 735     


Asn Arg Lys Lys Ile Leu Asn Leu Tyr Arg Asp Lys Leu Ser Asp Asn 
            740                 745                 750         


Met Glu Asn Met Glu Ser Met Met Gln Asp Glu His Leu Asp Phe Ile 
        755                 760                 765             


Phe Asn Arg His Leu Tyr Lys Ile Asp Thr Thr Glu Asn Gln Lys Leu 
    770                 775                 780                 


Lys Leu Leu Ala His Pro Phe Val Phe Pro Arg Gly Ile Phe Asp Glu 
785                 790                 795                 800 


Lys Pro Thr Tyr Ile Lys Gly Lys Ser Met Thr Glu Thr Pro Glu Leu 
                805                 810                 815     


Tyr Ala Glu Trp Tyr Arg Tyr Ala Asn Gln Arg Ile Glu Ser Gln Gln 
            820                 825                 830         


Phe Phe Tyr Lys Thr Pro Arg Asp Tyr Lys Asp Leu Tyr Asn Thr Met 
        835                 840                 845             


Lys Glu His Lys Lys Glu Ile Asp Glu Asn Lys Tyr Asn Leu Ser Glu 
    850                 855                 860                 


Ile Glu Lys Tyr Asn Leu Phe Lys Asn Lys Gln Asp Lys Ala Ile Lys 
865                 870                 875                 880 


Lys Val Gln Met Gln Asp Val Phe Leu Glu Leu Ile Val Lys Asp Leu 
                885                 890                 895     


Phe Asn Arg Ile Phe Pro Asn Gln Gly Cys Asp Phe Ser Leu Lys Asp 
            900                 905                 910         


Phe Thr Asp Ile His Asn Asp Thr Trp Asn Ile Ser Val Pro Phe Gln 
        915                 920                 925             


Trp Lys Gln Ile Arg Glu Pro Glu Val Lys Leu Lys Asp Ile Gly Lys 
    930                 935                 940                 


Phe Lys Arg Phe Leu Phe Asp Lys Lys Ile Glu Asn Ile Leu Ser Tyr 
945                 950                 955                 960 


Asn Glu Asp Lys Ile Trp Thr Lys Arg Glu Leu Glu Glu Glu Leu Glu 
                965                 970                 975     


Leu Leu Pro Ser Ser Tyr Glu Val Ile Arg Arg Glu Gln Leu Leu Lys 
            980                 985                 990         


Leu Ile Gln Glu Leu Glu Asn Cys  Ile Leu Gln Lys Asn  Asn Phe Asp 
        995                 1000                 1005             


Gly Val  Asn His Pro Lys Glu  Phe Glu Gln Ser Asp  Glu Asp Lys 
    1010                 1015                 1020             


Lys Ala  Tyr Pro Asn Phe Lys  His Tyr Ile Thr Glu  Gly Ile Leu 
    1025                 1030                 1035             


Lys Lys  Cys Thr Leu Ala Glu  Asn Thr Asp Ile Glu  Trp Leu Asn 
    1040                 1045                 1050             


Gln Leu  Lys Glu Asp Thr Phe  Glu Lys Val Pro Leu  Gln Glu Leu 
    1055                 1060                 1065             


Cys Met  Lys Pro Lys Ile Ile  Gln Lys Ala Tyr Leu  Leu Val Leu 
    1070                 1075                 1080             


Ile Arg  Asn Lys Ile Ser His  Asn Gln Leu Pro Lys  Lys Glu Tyr 
    1085                 1090                 1095             


Phe Glu  Arg Ile Lys Thr Met  Phe Ser Pro Ala Glu  Ala Asn Glu 
    1100                 1105                 1110             


Thr Ile  Ser Tyr Ser Ser Ile  Ile Leu Asn Phe Thr  Lys Ser Val 
    1115                 1120                 1125             


Ile Gln  Glu Leu Lys Thr Tyr  Leu Lys 
    1130                 1135         


<210>  2193
<211>  1146
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2193

Met Glu Ser Ile Ile Gly Leu Gly Leu Ser Phe Asn Pro Tyr Lys Thr 
1               5                   10                  15      


Ala Asp Lys His Tyr Phe Gly Ser Phe Leu Asn Leu Ala Asp Asn Asn 
            20                  25                  30          


Leu Lys Ala Val Phe Ala Glu Phe Lys Glu Arg Ile Ser Asp Lys Ser 
        35                  40                  45              


Lys Asp Glu Asp Ile Ser Asn Leu Ile Glu Lys His Phe Ile Asp Asn 
    50                  55                  60                  


Met Ser Ile Val Asp Tyr Glu Lys Asn Ile Ser Ile Leu Asn Gly Tyr 
65                  70                  75                  80  


Leu Pro Ile Ile Asp Phe Leu Asp Asp Glu Leu Glu Asn Asn Leu Asn 
                85                  90                  95      


Thr Arg Val Lys Asn Phe Lys Lys Ser Phe Ile Ile Leu Ala Glu Ala 
            100                 105                 110         


Leu Glu Thr Leu Arg Asn Tyr Tyr Thr His Phe Tyr His Asp Pro Ile 
        115                 120                 125             


Thr Phe Gly Asp Asn Lys Glu Pro Leu Leu Glu Leu Leu Asp Glu Val 
    130                 135                 140                 


Leu Leu Lys Thr Ile Leu Asp Val Lys Lys Lys Tyr Leu Lys Thr Asp 
145                 150                 155                 160 


Lys Thr Lys Glu Ile Leu Lys Asp Ser Leu Arg Glu Glu Met Asp Leu 
                165                 170                 175     


Leu Val Ile Arg Lys Thr Asp Glu Leu Arg Glu Lys Lys Lys Thr Asn 
            180                 185                 190         


Pro Lys Phe Lys Phe Ser Thr Asp Pro Thr Gln Ile Arg Asn Ser Ile 
        195                 200                 205             


Phe Asn Asp Ala Phe Gln Gly Leu Leu Tyr Glu Asp Lys Glu Asn Asn 
    210                 215                 220                 


Gly Lys Thr Gln Val Ser Tyr Arg Ala Lys Thr Lys Leu Asn Pro Lys 
225                 230                 235                 240 


Asp Ile His Lys Gln Glu Glu Arg Asp Phe Glu Ile Pro Leu Ser Thr 
                245                 250                 255     


Ser Gly Ile Val Phe Leu Met Ser Leu Phe Leu Ser Lys Lys Glu Ile 
            260                 265                 270         


Glu Asp Phe Lys Ser Asn Ile Lys Gly Phe Lys Gly Lys Val Val Lys 
        275                 280                 285             


Asp Glu Asn His Asn Ser Leu Lys Tyr Met Ala Thr His Arg Val Tyr 
    290                 295                 300                 


Ser Ile Leu Ala Phe Lys Gly Leu Lys Tyr Arg Ile Lys Thr Asp Thr 
305                 310                 315                 320 


Phe Ser Lys Val Thr Leu Met Met Gln Met Ile Asp Glu Leu Ser Lys 
                325                 330                 335     


Val Pro Asp Cys Val Tyr Gln Asn Leu Ser Glu Thr Lys Gln Lys Asp 
            340                 345                 350         


Phe Ile Glu Asp Trp Asn Glu Tyr Leu Lys Asp Asn Glu Glu Asn Thr 
        355                 360                 365             


Glu Asn Leu Glu Asn Ser Arg Val Val His Pro Leu Ile Arg Lys Arg 
    370                 375                 380                 


Tyr Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe 
385                 390                 395                 400 


Ala Asn Phe Lys Thr Leu Lys Phe Gln Val Phe Met Gly Tyr Tyr Ile 
                405                 410                 415     


His Asp Gln Arg Thr Lys Thr Ile Gly Thr Thr Asn Ile Thr Thr Glu 
            420                 425                 430         


Arg Thr Val Lys Glu Lys Ile Asn Val Phe Gly Lys Leu Ser Lys Met 
        435                 440                 445             


Asp Asn Leu Lys Lys His Phe Phe Ser Gln Leu Ser Asp Glu Glu Asn 
    450                 455                 460                 


Thr Asp Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Phe Leu Thr Gln 
465                 470                 475                 480 


Ala Asp Asn Ser Pro Ala Asn Asn Ile Pro Ile Tyr Leu Glu Leu Lys 
                485                 490                 495     


Asn Gln Gln Ile Ile Lys Glu Lys Asp Asp Ile Lys Ala Glu Val Asn 
            500                 505                 510         


Asn Ser Gln Asn Arg Asn Pro Asn Lys Pro Ser Lys Arg Asp Leu Leu 
        515                 520                 525             


Asn Lys Ile Ser Asn Thr Asn Glu Asp Phe Tyr Gln Gly Asp Pro Thr 
    530                 535                 540                 


Ala Ile Leu Ser Leu Asn Glu Ile Pro Ala Leu Leu His Leu Phe Leu 
545                 550                 555                 560 


Val Gln Pro Asp Asn Lys Thr Gly Gln Gln Ile Glu Asn Ile Ile Arg 
                565                 570                 575     


Ile Lys Ile Glu Lys Gln Phe Asn Ser Ile Lys Asn Pro Ser Lys Asp 
            580                 585                 590         


Asp Lys Gly Val Pro Lys Ser Leu Phe Ala Asp Thr Asn Val Arg Val 
        595                 600                 605             


Asn Ala Ile Lys Leu Lys Lys Asp Leu Gly Glu Glu Leu Asp Met Leu 
    610                 615                 620                 


Asn Lys Lys Gln Ile Val Phe Lys Glu Asn Gln Lys Ala Ser Ser Asn 
625                 630                 635                 640 


Tyr Asp Glu Leu Leu Lys Lys His Gln Phe Thr Pro Lys Asn Lys Arg 
                645                 650                 655     


Pro Ala Leu Arg Lys Tyr Val Phe Tyr Asn Ser Glu Lys Gly Glu Glu 
            660                 665                 670         


Ala Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Lys Gly Phe 
        675                 680                 685             


Lys Thr Lys Trp Lys Gly Tyr Gln His Ser Glu Leu Gln Arg Lys Leu 
    690                 695                 700                 


Ala Phe Tyr Asp Arg His Thr Lys Gln Asp Ile Lys Glu Leu Leu Ser 
705                 710                 715                 720 


Gly Cys Glu Phe Asp His Phe Leu Leu Asp Ile Asn Ala Cys Phe Lys 
                725                 730                 735     


Glu Asp Asp Phe Glu Asp Phe Phe Ser Lys Tyr Leu Lys Asn Arg Ile 
            740                 745                 750         


Glu Thr Leu Asn Ile Ile Leu Lys Gln Leu His Asp Phe Lys Asn Glu 
        755                 760                 765             


Pro Thr Pro Leu Lys Gly Val Phe Lys Asn Cys Leu Lys Phe Leu Lys 
    770                 775                 780                 


Gln Lys Asn Tyr Val Thr Glu Asn Pro Glu Ile Ile Lys Lys Arg Ile 
785                 790                 795                 800 


Leu Ala Lys Pro Ala Phe Leu Pro Arg Gly Ile Phe Asp Glu Arg Pro 
                805                 810                 815     


Thr Met Lys Lys Gly Lys Asn Pro Leu Ile Asp Arg Asp Glu Phe Ala 
            820                 825                 830         


Lys Trp Phe Val Glu Tyr Leu Glu Asn Lys Asp Tyr Gln Lys Phe Tyr 
        835                 840                 845             


Asn Ser Glu Glu Tyr Arg Ile Arg Asp Ala Asp Phe Lys Lys Asn Ala 
    850                 855                 860                 


Val Ile Lys Lys Gln Lys Leu Lys Asp Phe Tyr Thr Leu Gln Met Val 
865                 870                 875                 880 


Asn Tyr Leu Leu Lys Glu Val Phe Gly Lys Asp Glu Met Asn Leu Gln 
                885                 890                 895     


Leu Ser Glu Leu Phe Gln Thr Arg Gln Glu Arg Leu Lys Leu Gln Gly 
            900                 905                 910         


Ile Ala Lys Lys Gln Met Asn Lys Glu Thr Gly Asp Ser Ser Glu Asn 
        915                 920                 925             


Thr Arg Asn Gln Thr Tyr Ile Trp Asn Lys Asp Val Pro Val Ser Phe 
    930                 935                 940                 


Phe Asn Gly Lys Val Thr Ile Asp Lys Val Lys Leu Lys Asn Ile Gly 
945                 950                 955                 960 


Lys Tyr Lys Arg Tyr Glu Arg Asp Glu Arg Val Lys Thr Phe Ile Gly 
                965                 970                 975     


Tyr Glu Val Asp Glu Lys Trp Met Met Tyr Leu Pro His Asn Trp Lys 
            980                 985                 990         


Asp Arg Tyr Ser Val Lys Pro Ile  Asn Val Ile Asp Leu  Gln Ile Gln 
        995                 1000                 1005             


Glu Tyr  Glu Glu Ile Arg Ser  His Glu Leu Leu Lys  Glu Ile Gln 
    1010                 1015                 1020             


Asn Leu  Glu Gln Tyr Ile Tyr  Asp His Thr Thr Asp  Lys Asn Thr 
    1025                 1030                 1035             


Leu Leu  Gln Asp Gly Asn Pro  Asn Phe Lys Met Tyr  Val Leu Asn 
    1040                 1045                 1050             


Gly Leu  Leu Thr Gly Ile Lys  Gln Val Asn Ile Ala  Asp Phe Ile 
    1055                 1060                 1065             


Val Leu  Lys Gln Asn Thr Asn  Phe Asp Lys Ile Asp  Phe Thr Gly 
    1070                 1075                 1080             


Ile Ala  Ser Cys Ser Glu Leu  Glu Lys Lys Thr Ile  Ile Leu Ile 
    1085                 1090                 1095             


Ala Ile  Arg Asn Lys Phe Ala  His Asn Gln Leu Pro  Asn Lys Thr 
    1100                 1105                 1110             


Ile Tyr  Asp Leu Ala Asn Glu  Phe Leu Lys Lys Glu  Lys Arg Glu 
    1115                 1120                 1125             


Thr Tyr  Ala Asn Tyr Tyr Leu  Lys Val Leu Lys Lys  Met Ile Ser 
    1130                 1135                 1140             


Asp Leu  Ala 
    1145     


<210>  2194
<211>  1148
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2194

Met Asn Asn Asn Ile Leu Glu Gln Ser Thr Ser Gly Ser Glu Lys Arg 
1               5                   10                  15      


Ala Ser Thr Arg Thr Leu Glu Ala Asp Pro Gln Tyr Phe Gly Val Tyr 
            20                  25                  30          


Ile Asn Met Ala Arg His Asn Val Phe Gln Ile Ile Asn Ala Leu Thr 
        35                  40                  45              


His Lys Phe Ser Lys Gln Ile Glu Asn Ala Lys Pro Ile Asn Asp Asp 
    50                  55                  60                  


Glu Asn Ile Ala Asn Asp Tyr Leu Ile Asn Ile Gly Lys Gly Thr Asp 
65                  70                  75                  80  


Lys Ser Pro Thr Ile Ile Glu Val Leu Asn Pro Ala His Pro Leu His 
                85                  90                  95      


Arg Leu Tyr Gly Glu His Val Phe Arg Ala Leu Lys Arg Tyr Leu Pro 
            100                 105                 110         


Leu Val Thr Ile Phe Glu Val Pro Ser Ile Asn Thr Glu Asp Ile Ile 
        115                 120                 125             


Lys Asp Thr Asp Asp Ile Leu Pro Val Leu Phe Gln Asp Leu Tyr Glu 
    130                 135                 140                 


Phe Ile Thr Leu Leu Phe Tyr Glu Leu Val Lys Phe Arg Asp Ala Tyr 
145                 150                 155                 160 


Thr His Ala Leu Ala Leu Asp Glu Gln Gly Asn Ile Val Pro Arg Lys 
                165                 170                 175     


Ile Asp Leu His Pro Asn Leu Arg His Tyr Phe Glu His Leu Phe Tyr 
            180                 185                 190         


Lys Ala Pro Asp Tyr Thr Leu Arg Arg Phe Arg Ser Thr Gln Glu Lys 
        195                 200                 205             


Ile Ala His Gly Phe His Glu Lys Asp Phe Ala Leu Leu Lys Ala His 
    210                 215                 220                 


Asn Leu Tyr Gln Asp Pro His Ser Asn Glu Leu Thr Thr Gln Gly Leu 
225                 230                 235                 240 


Phe Phe Phe Thr Thr Leu Phe Leu Glu Gln Lys Tyr Ala Tyr Gln Phe 
                245                 250                 255     


Leu Lys Arg Phe Asn Gly Phe Lys Asn Glu Thr Ile Gln Pro Phe Lys 
            260                 265                 270         


Ala Thr Leu Arg Val Phe Thr Ala Phe Thr Val Lys Leu Pro Asn Asp 
        275                 280                 285             


Lys Leu Ala Ser Asp His Pro Gly Gln Ser Phe Leu Leu Asp Met Leu 
    290                 295                 300                 


Asn Glu Leu Asn Lys Ile Pro Gln Ser Leu Phe Lys His Leu Thr Pro 
305                 310                 315                 320 


Lys Asp Gln Glu Met Phe Glu Arg Ile Asn Asp Glu Ala Leu Thr Asn 
                325                 330                 335     


Ile Leu Lys Asn Thr Asp Glu Ala Ser Phe Lys Asp Val Asp Asp Leu 
            340                 345                 350         


Leu Gly Lys Met Ala Pro Leu Ile Arg Arg Glu Asp Arg Phe Pro Tyr 
        355                 360                 365             


Phe Ala Leu Trp Phe Leu Glu Gln Thr Lys Ala Phe Asn His Ile Arg 
    370                 375                 380                 


Phe Gln Ile Ser Ile Gly Lys Ile Ala Tyr Ser Pro Tyr Asp Lys Thr 
385                 390                 395                 400 


Ile Ile Gly Glu Thr Ser Pro Arg Ile Ile Lys Phe Asp Ile His Gly 
                405                 410                 415     


Phe Gly Ser Leu Ala Glu Phe Ser Asp Glu Asp Thr Leu Leu Thr Thr 
            420                 425                 430         


Leu Lys Arg Gln Leu Pro Ala Gly Ser Pro His Ala Ser Leu Thr Phe 
        435                 440                 445             


Ser Gln Tyr Ala Pro His Tyr His Ile Lys Asn Asn Lys Ile Gly Ile 
    450                 455                 460                 


Leu Val Asp Tyr Pro Ser Gly Asp Arg Pro Leu Ser Asn Ile Thr Gln 
465                 470                 475                 480 


Gln Pro Asp Gly Lys Ile Lys Val Asn His Ile Lys Pro Thr Ala Phe 
                485                 490                 495     


Ile Ser Ile Asn Glu Leu Pro Lys Leu Val Val Leu Ala Leu Leu Gly 
            500                 505                 510         


Thr Asn Lys Asp Asn Lys Pro Ile Gly Asn Asp Ile Glu Arg Leu Ile 
        515                 520                 525             


Arg Ser Phe Ile Thr Lys Phe Lys Asn Gln Leu Phe His Leu Ala Pro 
    530                 535                 540                 


Leu Thr Lys Ile Lys Asn Gly Leu Thr Phe Ser Pro Glu Thr Phe Thr 
545                 550                 555                 560 


Arg Arg Met Asp Lys Asp Lys Met Val Lys Gly Arg Ile Pro Lys Ser 
                565                 570                 575     


Glu Leu Ala Lys Arg Glu Glu Tyr Lys Ile Tyr Leu Glu Lys Arg Lys 
            580                 585                 590         


Ala Val Leu Gln Gly Thr Thr Asp Leu Lys Leu Asn Val Asn Gln Leu 
        595                 600                 605             


Pro Thr Lys Ile Gln Asn Tyr Leu Leu Asn Ile Asp Glu Val Ser Asp 
    610                 615                 620                 


Glu Lys Ser Ile His Leu Arg Ile Lys Thr Met Ile Lys Glu Val Glu 
625                 630                 635                 640 


Tyr Arg Leu Lys Lys Ile Asp Arg Asn Lys Leu Pro Lys Val Gly Asp 
                645                 650                 655     


Ile Ala Thr Tyr Ile Ala Arg Asp Met Leu Asp Met Val Ala Asp Val 
            660                 665                 670         


Arg Thr Lys Ser Arg Ile Thr Ser Ala Tyr Tyr Ser Gln Ile Gln Arg 
        675                 680                 685             


Ala Leu Ala Tyr Phe Ala Leu Asp Lys Thr Arg Leu Ile Asp Leu Cys 
    690                 695                 700                 


Asp Glu Leu Gly Leu Phe Asn His Gln Thr Gly His Val Phe Leu Ile 
705                 710                 715                 720 


Arg Glu Ile Phe Leu Asn Asn His His Ile Leu Gly Val Tyr Arg Glu 
                725                 730                 735     


Tyr Leu Thr Lys Lys Gln Asn Trp Ile Asp Gln Asn Leu Ile Val Lys 
            740                 745                 750         


Ile Gln Glu Arg Gly Lys Arg Leu Thr Lys Tyr Ile Leu Pro Thr Asn 
        755                 760                 765             


Arg Pro Leu Pro Tyr Lys Met Lys Gln Ser Ile Asn Lys Gly Phe Glu 
    770                 775                 780                 


Phe Asn Ala Trp Leu Gln His Lys Ser Thr Met Pro Ile Asp Leu Pro 
785                 790                 795                 800 


Thr Thr Leu Phe Asp Glu Ser Leu Thr Ser Leu Leu Lys Lys Thr Ile 
                805                 810                 815     


Ala Gln Lys Leu Gly Ile Ala Ser Lys Ser Glu Asp Lys Phe Gly Arg 
            820                 825                 830         


Leu Leu Asp Arg Leu Leu Lys Gln Asp Thr Gln Pro Phe Tyr Lys Phe 
        835                 840                 845             


Glu Arg Ile Tyr Arg Lys Pro Phe Ser Gln Glu Glu Pro Glu Pro Phe 
    850                 855                 860                 


Asn Ile Leu Lys Leu Thr His Thr Ala Leu Lys Gln Arg Phe Gly Lys 
865                 870                 875                 880 


Pro Ala Glu Val Asn Glu Lys Ile Ile Arg His His Gln Arg Lys Asp 
                885                 890                 895     


Gln Ile Val Arg Leu Met Cys Glu His Leu Phe Lys Asn Asn Ser Glu 
            900                 905                 910         


Leu Ala Phe Glu Gly Glu Phe Leu Leu Glu Asn Leu His Pro Ala Ser 
        915                 920                 925             


Arg Asn Asn Pro Leu Asp Ala Pro Met Val Phe Glu Gln Thr Ile Pro 
    930                 935                 940                 


His Thr His Lys Lys Ile Val Ala Gln Asp Ser Asn Lys Trp Ile Gln 
945                 950                 955                 960 


Glu Val Lys Lys Thr Asn Asn Arg Asn Lys Ala Trp Tyr Arg Trp Thr 
                965                 970                 975     


Leu Lys Asp Phe Gly Thr Phe Arg Lys Ile Ile His Asp Arg Arg Leu 
            980                 985                 990         


Pro Ala Leu Val Asn Ser Ile Thr  Gly Asp Glu Ile Asp  Phe Asp Leu 
        995                 1000                 1005             


Val Gln  Phe Glu Leu Ala Ala  Tyr Asp Arg Ala Arg  Glu Thr Ile 
    1010                 1015                 1020             


Phe Asp  Gln Leu Phe Leu Leu  Glu Gln Phe Ile Ala  Asp Lys Asp 
    1025                 1030                 1035             


Met Ser  Tyr Ile Lys Gln His  Lys Ala Ile Glu Arg  Met Gln Asp 
    1040                 1045                 1050             


Gly Lys  Gly Phe Asp Glu Val  Gln Phe Asn Thr Tyr  Ala Asp Trp 
    1055                 1060                 1065             


Leu Ser  Asp Lys Gly Leu Leu  Thr Pro Asp Glu Ile  Asn Gly Leu 
    1070                 1075                 1080             


Lys Glu  Ile Arg Asn Arg Phe  Ser His Asn Gln Trp  Pro Gly Ile 
    1085                 1090                 1095             


Ser Lys  Leu Gly Ile Gln Pro  Ile Ser Gln Glu Gln  Gln Ser Ala 
    1100                 1105                 1110             


Phe Val  Thr His Leu Asn Ile  Lys Gly Trp Val Asn  Glu His His 
    1115                 1120                 1125             


Thr Pro  Leu Ala Met Phe Met  Glu Lys Leu Val Ile  Asn Trp Val 
    1130                 1135                 1140             


Ser Lys  Ala Ile Thr 
    1145             


<210>  2195
<211>  1146
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2195

Met Glu Ser Ile Ile Gly Leu Gly Leu Ser Phe Asn Pro Tyr Lys Thr 
1               5                   10                  15      


Ala Asp Lys His Tyr Phe Gly Ser Phe Leu Asn Leu Ala Asp Asn Asn 
            20                  25                  30          


Leu Lys Ala Val Phe Ala Glu Phe Lys Glu Arg Ile Ser Asp Lys Ser 
        35                  40                  45              


Lys Asp Glu Asp Ile Ser Asn Leu Ile Glu Lys His Phe Ile Asp Asn 
    50                  55                  60                  


Met Ser Ile Val Asp Tyr Glu Lys Asn Ile Ser Ile Leu Asn Gly Tyr 
65                  70                  75                  80  


Leu Pro Ile Ile Asp Phe Leu Asp Asp Glu Leu Glu Asn Asn Leu Asn 
                85                  90                  95      


Thr Arg Val Lys Asn Phe Lys Lys Ser Phe Ile Ile Leu Ala Glu Ala 
            100                 105                 110         


Leu Glu Thr Leu Arg Asn Tyr Tyr Thr His Phe Tyr His Asp Pro Ile 
        115                 120                 125             


Thr Phe Gly Asp Asn Lys Glu Pro Leu Leu Glu Leu Leu Asp Glu Val 
    130                 135                 140                 


Leu Leu Lys Thr Ile Leu Asp Val Lys Lys Lys Tyr Leu Lys Thr Asp 
145                 150                 155                 160 


Lys Thr Lys Glu Ile Leu Lys Asp Ser Leu Arg Glu Glu Met Asp Leu 
                165                 170                 175     


Leu Val Ile Arg Lys Thr Asp Glu Leu Arg Glu Lys Lys Lys Thr Asn 
            180                 185                 190         


Pro Lys Phe Lys Phe Ser Thr Asp Pro Thr Gln Ile Arg Asn Ser Ile 
        195                 200                 205             


Phe Asn Asp Ala Phe Gln Gly Leu Leu Tyr Glu Asp Lys Glu Asn Asn 
    210                 215                 220                 


Gly Lys Thr Gln Val Ser Tyr Arg Ala Lys Thr Lys Leu Asn Pro Lys 
225                 230                 235                 240 


Asp Ile His Lys Gln Glu Glu Arg Asp Phe Glu Ile Pro Leu Ser Thr 
                245                 250                 255     


Ser Gly Ile Val Phe Leu Met Ser Leu Phe Leu Ser Lys Lys Glu Ile 
            260                 265                 270         


Glu Asp Phe Lys Ser Asn Ile Lys Gly Phe Lys Gly Lys Val Val Lys 
        275                 280                 285             


Asp Glu Asn His Asn Ser Leu Lys Tyr Met Ala Thr His Arg Val Tyr 
    290                 295                 300                 


Ser Ile Leu Ala Phe Lys Gly Leu Lys Tyr Arg Ile Lys Thr Asp Thr 
305                 310                 315                 320 


Phe Ser Lys Val Thr Leu Met Met Gln Met Ile Asp Glu Leu Ser Lys 
                325                 330                 335     


Val Pro Asp Cys Val Tyr Gln Asn Leu Ser Glu Thr Lys Gln Lys Asp 
            340                 345                 350         


Phe Ile Glu Asp Trp Asn Glu Tyr Leu Lys Asp Asn Glu Glu Asn Thr 
        355                 360                 365             


Glu Asn Leu Glu Asn Ser Arg Val Val His Pro Leu Ile Arg Lys Arg 
    370                 375                 380                 


Tyr Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe 
385                 390                 395                 400 


Ala Asn Phe Lys Thr Leu Lys Phe Gln Val Phe Met Gly Tyr Tyr Ile 
                405                 410                 415     


His Asp Gln Arg Thr Lys Thr Ile Gly Thr Thr Asn Ile Thr Thr Glu 
            420                 425                 430         


Arg Thr Val Lys Glu Lys Ile Asn Val Phe Gly Lys Leu Ser Lys Met 
        435                 440                 445             


Asp Asn Leu Lys Lys His Phe Phe Ser Gln Leu Ser Asp Glu Glu Asn 
    450                 455                 460                 


Thr Asp Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Phe Leu Thr Gln 
465                 470                 475                 480 


Ala Asp Asn Ser Pro Ala Asn Asn Ile Pro Ile Tyr Leu Glu Leu Lys 
                485                 490                 495     


Asn Gln Gln Ile Ile Lys Glu Lys Asp Asp Ile Lys Ala Glu Val Asn 
            500                 505                 510         


Asn Ser Gln Asn Arg Asn Pro Asn Lys Pro Ser Lys Arg Asp Leu Leu 
        515                 520                 525             


Asn Lys Ile Ser Asn Thr Asn Glu Asp Phe Tyr Gln Gly Asp Pro Thr 
    530                 535                 540                 


Ala Ile Leu Ser Leu Asn Glu Ile Pro Ala Leu Leu His Leu Phe Leu 
545                 550                 555                 560 


Val Gln Pro Asp Asn Lys Thr Gly Gln Gln Ile Glu Asn Ile Ile Arg 
                565                 570                 575     


Ile Lys Ile Glu Lys Gln Phe Asn Ser Ile Lys Asn Pro Ser Lys Asp 
            580                 585                 590         


Asp Lys Gly Val Pro Lys Ser Leu Phe Ala Asp Thr Asn Val Arg Val 
        595                 600                 605             


Asn Ala Ile Lys Leu Lys Lys Asp Leu Gly Glu Glu Leu Asp Met Leu 
    610                 615                 620                 


Asn Lys Lys Gln Ile Val Phe Lys Glu Asn Gln Lys Ala Ser Ser Asn 
625                 630                 635                 640 


Tyr Asp Glu Leu Leu Lys Lys His Gln Phe Thr Pro Lys Asn Lys Arg 
                645                 650                 655     


Pro Ala Leu Arg Lys Tyr Val Phe Tyr Asn Ser Glu Lys Gly Glu Glu 
            660                 665                 670         


Ala Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Lys Gly Phe 
        675                 680                 685             


Lys Thr Lys Trp Lys Gly Tyr Gln His Ser Glu Leu Gln Arg Lys Leu 
    690                 695                 700                 


Ala Phe Tyr Asp Arg His Thr Lys Gln Asp Ile Lys Glu Leu Leu Ser 
705                 710                 715                 720 


Gly Cys Glu Phe Asp His Phe Leu Leu Asp Ile Asn Ala Cys Phe Lys 
                725                 730                 735     


Glu Asp Asp Phe Glu Asp Phe Phe Ser Lys Tyr Leu Lys Asn Arg Ile 
            740                 745                 750         


Glu Thr Leu Asn Ile Ile Leu Lys Gln Leu His Asp Phe Lys Asn Glu 
        755                 760                 765             


Pro Thr Pro Leu Lys Gly Val Phe Lys Asn Cys Leu Lys Phe Leu Lys 
    770                 775                 780                 


Gln Lys Asn Tyr Val Thr Glu Asn Pro Glu Ile Ile Lys Lys Arg Ile 
785                 790                 795                 800 


Leu Ala Lys Pro Ala Phe Leu Pro Arg Gly Ile Phe Asp Glu Arg Pro 
                805                 810                 815     


Thr Met Lys Lys Gly Lys Asn Pro Leu Ile Asp Arg Asp Glu Phe Ala 
            820                 825                 830         


Lys Trp Phe Val Glu Tyr Leu Glu Asn Lys Asp Tyr Gln Lys Phe Tyr 
        835                 840                 845             


Asn Ser Glu Glu Tyr Arg Ile Arg Asp Ala Asp Phe Lys Lys Asn Ala 
    850                 855                 860                 


Val Ile Lys Lys Gln Lys Leu Lys Asp Phe Tyr Thr Leu Gln Met Val 
865                 870                 875                 880 


Asn Tyr Leu Leu Lys Glu Val Phe Gly Lys Asp Glu Met Asn Leu Gln 
                885                 890                 895     


Leu Ser Glu Leu Phe Gln Thr Arg Gln Glu Arg Leu Lys Leu Gln Gly 
            900                 905                 910         


Ile Ala Lys Lys Gln Met Asn Lys Glu Thr Gly Asp Ser Ser Glu Asn 
        915                 920                 925             


Thr Arg Asn Gln Thr Tyr Ile Trp Asn Lys Asp Val Pro Val Ser Phe 
    930                 935                 940                 


Phe Asn Gly Lys Val Thr Ile Asp Lys Val Lys Leu Lys Asn Ile Gly 
945                 950                 955                 960 


Lys Tyr Lys Arg Tyr Glu Arg Asp Glu Arg Val Lys Thr Phe Ile Gly 
                965                 970                 975     


Tyr Glu Val Asp Glu Lys Trp Met Met Tyr Leu Pro His Asn Trp Lys 
            980                 985                 990         


Asp Arg Tyr Ser Val Lys Pro Ile  Asn Val Ile Asp Leu  Gln Ile Gln 
        995                 1000                 1005             


Glu Tyr  Glu Glu Ile Arg Ser  His Glu Leu Leu Lys  Glu Ile Gln 
    1010                 1015                 1020             


Asn Leu  Glu Gln Tyr Ile Tyr  Asp His Thr Thr Asp  Lys Asn Thr 
    1025                 1030                 1035             


Leu Leu  Gln Asp Gly Asn Pro  Asn Phe Lys Met Tyr  Val Leu Asn 
    1040                 1045                 1050             


Gly Leu  Leu Thr Gly Ile Lys  Gln Val Asn Ile Ala  Asp Phe Ile 
    1055                 1060                 1065             


Val Leu  Lys Gln Asn Thr Asn  Phe Asp Lys Ile Asp  Phe Thr Gly 
    1070                 1075                 1080             


Ile Ala  Ser Cys Ser Glu Leu  Glu Lys Lys Thr Ile  Ile Leu Ile 
    1085                 1090                 1095             


Ala Ile  Arg Asn Lys Phe Ala  His Asn Gln Leu Pro  Asn Lys Thr 
    1100                 1105                 1110             


Ile Tyr  Asp Leu Ala Asn Glu  Phe Leu Lys Lys Glu  Lys Arg Glu 
    1115                 1120                 1125             


Thr Tyr  Ala Asn Tyr Tyr Leu  Lys Val Leu Lys Lys  Met Ile Ser 
    1130                 1135                 1140             


Asp Leu  Ala 
    1145     


<210>  2196
<211>  1147
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2196

Met Glu Ile Ala Pro Gln Gln Ser Glu Thr Gln Lys Lys Lys Arg Ser 
1               5                   10                  15      


Leu Asp Gln Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg 
            20                  25                  30          


His Asn Val Phe Leu Ile Val Asn His Leu Thr Asp Thr Phe Lys Glu 
        35                  40                  45              


Leu Asn Phe Lys Lys Leu Ala Asn Glu Glu Asp Ile Trp Lys Val Asp 
    50                  55                  60                  


Asn Ser Ser Asn Ile Leu Leu Asn Val Phe Asp Val Thr Gln Ser Lys 
65                  70                  75                  80  


Tyr Glu Asp Phe Arg Pro Arg Ile Phe His Tyr Leu Ile Lys Arg His 
                85                  90                  95      


His Leu Pro Leu Val Lys Ile Phe Asn Thr Glu Tyr Leu Gly Glu Asn 
            100                 105                 110         


Ile Leu Gln Asp Lys Ser Val Asp Tyr Glu Arg Leu His Gln Phe Leu 
        115                 120                 125             


Cys Leu Ser Phe Lys Glu Leu Thr Glu Phe Arg Asp Ser Tyr Ser His 
    130                 135                 140                 


Ser Ile Ala Ile Asp Glu Asn Gly Asn Lys Val Ser Arg Lys Thr Thr 
145                 150                 155                 160 


Leu Ala Asn Glu Leu Val Pro Glu Ile Asn Leu Leu Phe Lys Tyr Ala 
                165                 170                 175     


Pro Arg Tyr Ser Phe Leu Arg Asn Tyr Gln Thr Leu Asn Glu Gly Asp 
            180                 185                 190         


Phe Gln His Leu Asp Asn Tyr Gln Leu Phe Val Ala Asp Asn Gln Leu 
        195                 200                 205             


Thr His Gln Gly Arg Phe Phe Phe Ile Asn Leu Phe Leu Glu Arg Ser 
    210                 215                 220                 


Tyr Gly Ile Lys Phe Leu Lys Arg Phe Arg Gly Phe Lys Asn Glu Asn 
225                 230                 235                 240 


Thr Pro Pro Phe Lys Ala Thr Ile Gln Ser Phe Thr Thr Tyr Cys Leu 
                245                 250                 255     


Lys Val Pro Asp Ile Arg Leu Gly Asn Glu Asn Pro Lys Gln Ser Leu 
            260                 265                 270         


Leu Leu Asp Met Leu Thr Glu Leu Asn Lys Cys Pro Lys Glu Leu Phe 
        275                 280                 285             


Asn His Leu Thr Glu Asp Asp Lys Lys Glu Phe Glu Pro Asn Leu Asp 
    290                 295                 300                 


Glu Thr Ser Ser Thr Asn Val Leu Leu Asn Ser Thr Asn Tyr Glu Phe 
305                 310                 315                 320 


Phe Asp Ala Asp Glu Val Glu Glu Ala Ile Arg Glu Leu Thr Ala Gln 
                325                 330                 335     


Lys Arg His Asn Asp Arg Phe Pro Tyr Leu Ala Leu Arg Phe Leu Asp 
            340                 345                 350         


Glu Thr Met Ala Phe Ser Gln Leu Arg Phe Gln Leu Ser Leu Gly Lys 
        355                 360                 365             


Leu Ile Ile Lys Lys Pro Tyr Gln Lys Thr Ile Leu Gly Gln Pro Asn 
    370                 375                 380                 


Asp Arg Ile Ile Thr Lys Lys Leu Asn Val Phe Gly Arg Ile Ser Asp 
385                 390                 395                 400 


Phe Leu Asn Arg Glu Lys Glu Ile Ile Arg Ala Leu Ser Asn Asp Gln 
                405                 410                 415     


Asn Val Asp Phe Leu Glu Phe Glu Gln Phe Phe Pro His Tyr Asn Ile 
            420                 425                 430         


Asn Asn Asn Lys Ile Ala Phe Tyr Phe Leu Asn Asp Ser Asp Leu Thr 
        435                 440                 445             


Glu Glu Asn Leu Glu Ser Arg Leu Arg Asp Gln Glu Asn Arg Gln Pro 
    450                 455                 460                 


Thr Gly Phe Leu Ser Ile His Asp Leu Pro Lys Leu Val Leu Leu His 
465                 470                 475                 480 


Leu Leu Ala Pro Ser Glu Val Gln Lys Thr Leu Gln Arg Phe Ile Asn 
                485                 490                 495     


Asp Asn Asn Pro Ala Phe Phe Asp Leu Glu Leu Leu Ser Asn Ile Lys 
            500                 505                 510         


Ser Lys Val Val Tyr Glu Pro Ser Asn Phe Thr Lys Arg Ser Glu His 
        515                 520                 525             


Gln Tyr Arg Asp Ala Asp Lys Gln Glu Glu Glu Thr Glu Lys Gln Gln 
    530                 535                 540                 


Glu Tyr Gln Thr Leu Leu Asn Gln Arg Lys Arg Leu Leu Glu Gln His 
545                 550                 555                 560 


Leu Pro Lys Gly Val Lys Ile Asn Gln Ile Pro Glu Lys Val Leu Asp 
                565                 570                 575     


Phe Leu Met Asn Ile Ser Glu Pro Asn Glu Asn Lys Val Ile His Gln 
            580                 585                 590         


Lys Ile Lys Ser Ile Lys Asp Glu Ala Lys Thr Leu Leu Gln Arg Val 
        595                 600                 605             


Lys Asn Lys Gln Ala Ala Asn Glu Ile Pro Lys Leu Gly Glu Leu Ala 
    610                 615                 620                 


Thr Phe Leu Thr Arg Asp Ile Ile Asn Met Val Val Ser Glu Glu Leu 
625                 630                 635                 640 


Lys Lys Lys Ile Thr Ser Pro Tyr Ser Asn Lys Leu Gln Asn Lys Ile 
                645                 650                 655     


Ala Phe Phe Ser Leu Ser Lys Gln Glu Ile Ile Ser Leu Leu Asn Glu 
            660                 665                 670         


Leu Gln Leu Leu Asn Asn Glu Lys Gly His Val Phe Leu Ser Ser Arg 
        675                 680                 685             


Leu Ile Leu Glu Ser Asn Gly Leu Leu Ser Phe Tyr Lys Ser Tyr Leu 
    690                 695                 700                 


Glu Ala Lys Ile Ala Trp Ile Asp Lys Asn Leu Phe Leu Lys Gly Lys 
705                 710                 715                 720 


Lys Gly Gly Tyr Ile Ile Pro Glu Asn Lys Pro Val Pro Lys Thr Leu 
                725                 730                 735     


Gln Lys Ile Lys Gln Glu Val Ser Gln Phe Asp Phe Thr Gln Trp Leu 
            740                 745                 750         


Gln Asn Lys Ala Ala Met Pro Ile Asp Val Pro Asn Thr Ile Phe Asp 
        755                 760                 765             


Val Thr Leu Glu Asn Leu Leu Lys Thr Asn Leu Lys Lys Arg Gly Ile 
    770                 775                 780                 


Thr Val Lys Asp Thr Asp Lys Phe Ser Val Leu Leu Asn Lys Tyr Met 
785                 790                 795                 800 


Asp Lys Asp Thr Gln Pro Phe Tyr Gln Tyr Ser Arg Val Tyr Lys Lys 
                805                 810                 815     


Gln Asp Glu Glu Glu Ser Val Gln Val Val Gly Lys Trp Gly Lys Thr 
            820                 825                 830         


Leu Lys Lys Gln Tyr Gly Lys Phe Val Glu Glu Asn Glu Lys Val Ile 
        835                 840                 845             


Arg Phe Tyr Gln Ser Lys Asp Arg Val Ile Lys Leu Met Cys Asn Ala 
    850                 855                 860                 


Leu Leu Gln Ala Glu Asn Lys Thr Ala Leu Thr Asp Ser Phe Lys Leu 
865                 870                 875                 880 


Ala His Thr His Pro Asn Ser Lys Gln Asn Pro Leu Asp Thr Pro Met 
                885                 890                 895     


Arg Phe Glu Gln Lys Leu Phe Ser Asn Asp Lys Glu Thr Lys Val Leu 
            900                 905                 910         


Cys Thr Ile Tyr Ala Gln Asp Thr Glu Asn Gln Lys Asn Glu Ile Leu 
        915                 920                 925             


Ala Trp Asn Ser Leu Ser Glu Asp Asp Lys Lys Tyr Trp Leu Thr Leu 
    930                 935                 940                 


Thr Thr Lys Glu Ala Gln Lys Glu Trp Leu Ser Gly Lys Pro Glu Thr 
945                 950                 955                 960 


Glu Gln Glu Val Tyr His Gly Gln Lys Gly Tyr Gln Trp Thr Ile Lys 
                965                 970                 975     


Glu Val Gly Lys Phe Lys Arg Phe Val Lys Asp Arg Arg Ile Pro Ala 
            980                 985                 990         


Leu Val Asn Tyr Phe Glu Thr Thr  Lys Leu Pro Phe Ser  Leu Leu Glu 
        995                 1000                 1005             


Tyr Gln  Leu Lys Glu Tyr Asp  Arg Val Arg Glu Gln  Ile Phe Asp 
    1010                 1015                 1020             


Gly Val  Phe Lys Leu Glu Glu  Ala Ile Ser Gln Lys  Asp Trp Ala 
    1025                 1030                 1035             


Gly Ile  Trp Ala Leu Glu Gln  Glu Ala Arg Gly Arg  Lys Asn Tyr 
    1040                 1045                 1050             


His Gln  Val Gln Phe Asn Ile  Phe Glu Lys Tyr Leu  Gln Asn Thr 
    1055                 1060                 1065             


Leu Pro  Ser Tyr Asp Pro Ala  Ile Gly Val Ile Arg  Asn Lys Phe 
    1070                 1075                 1080             


Ser His  Asn Glu Phe Pro Asp  Leu Ile Gly Gln Gly  Ile Glu Lys 
    1085                 1090                 1095             


Ile Ser  Gln Ala Gln Ile Asp  Asp Tyr Glu Arg Asn  Lys His Leu 
    1100                 1105                 1110             


Lys Asp  Tyr Leu Ala His Ala  Gly Ile Ser Ile Ala  Gln Gln Ile 
    1115                 1120                 1125             


Leu Val  Ile Phe Glu Gln Lys  Ile Asn Asp Thr Leu  Thr Gln Leu 
    1130                 1135                 1140             


Thr Thr  His Gly 
    1145         


<210>  2197
<211>  1090
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2197

Met Met Thr Gln Gln Lys Thr Leu Pro Glu Lys Arg Met Asp Ala Leu 
1               5                   10                  15      


Ala Asp Leu His Ile Asn Pro Thr His Lys Leu Arg Lys Asp Glu Ser 
            20                  25                  30          


Pro Tyr Phe Leu Leu Tyr Leu Asn Tyr Ala Val Asn Asn Ile Cys Asp 
        35                  40                  45              


Ile Thr Gly Ile Asp Gln Ser Ile Asn Gln Glu Phe Arg Ala Cys Gln 
    50                  55                  60                  


Glu Ile Lys Gln Lys Gly Thr Ala Val Ile Arg Lys Leu Ala Asn Phe 
65                  70                  75                  80  


Phe Trp Leu Phe Gln Ala Glu Asp Pro Met Arg Asp Phe Pro Asp Tyr 
                85                  90                  95      


Glu Glu Lys Thr Leu Met Ile Val Glu Lys Ile Tyr Ala Leu Arg Asn 
            100                 105                 110         


Tyr Phe Ala His Leu Glu Gln Asn Gly Ser Gly Pro Leu Val Val Thr 
        115                 120                 125             


Arg Asp Phe Tyr Val Phe Val Glu Gly Cys Leu Ala Gly Lys Ala Lys 
    130                 135                 140                 


Glu Arg Ile Met Arg Pro Gly Ile Arg Met Asp Lys Leu Phe Lys Met 
145                 150                 155                 160 


Lys Leu Phe Ala Gln His Asp Arg Thr Gln Gln Thr Tyr Asp Phe Thr 
                165                 170                 175     


Arg Lys Gly Leu Ile Phe Leu Ile Cys Leu Ala Leu Tyr Arg Asp Asp 
            180                 185                 190         


Ala Met Glu Phe Thr Gln Cys Leu Glu Asp Met Lys Leu Pro Ala Cys 
        195                 200                 205             


Pro Lys Asn Ser Val Ser Leu Glu Asp Cys Met Thr Leu Cys Ser Glu 
    210                 215                 220                 


Glu Asn Ala Ser Val Cys Lys Pro Gly Ser Ala Arg Ala Phe Ile Glu 
225                 230                 235                 240 


Phe Phe Thr Cys Tyr Ser Ala Arg Arg Gly Arg Ser Val Asn Phe Leu 
                245                 250                 255     


Thr Glu Asp Ser Ser Asp Ser Gly Lys Ile His Ser Cys Leu Ser Tyr 
            260                 265                 270         


Leu Ser Phe Ala Asp Ile Ile Gly Tyr Leu Asn Lys Val Pro Pro Ala 
        275                 280                 285             


Ala Met Asp Tyr Leu Ser Leu Glu Ser Glu Asn Ala Arg Leu Ala Leu 
    290                 295                 300                 


Glu Lys Ser Gln Ser Thr Glu Ser Glu Glu Asn Lys Glu Phe Lys Tyr 
305                 310                 315                 320 


Lys Leu His Lys Arg Phe Arg Asp Arg Phe Leu Ser Phe Ala Ala Ser 
                325                 330                 335     


Trp Cys Glu Asp Phe Asp Ala Phe Pro Cys Met Lys Phe Lys Arg Leu 
            340                 345                 350         


Asp Ile Ser Glu Ser Glu Gly Arg Lys Arg Tyr Val Phe Gly Lys Glu 
        355                 360                 365             


Asn Asp Asn Arg Val His Met Asp Arg His Tyr Gln Ile Lys Asp Asn 
    370                 375                 380                 


Ala Ile Arg Phe Ala Trp Val Pro Glu Lys His Tyr Gly Glu Ile His 
385                 390                 395                 400 


Ile Asp Ser Leu Arg Ser Ala Val Thr Ala Gly Thr Met Lys Gln Leu 
                405                 410                 415     


Leu Phe Ala Lys Leu Asn Gly Asp Lys Asn Val Glu Thr Met Val Asp 
            420                 425                 430         


Lys Tyr Phe Thr Ala Tyr His Arg Ile Leu Glu Thr Val Val Asn Thr 
        435                 440                 445             


Lys Asp Pro Asn Asp Leu Tyr Leu Glu Gly Thr Leu Leu Asp Asp Phe 
    450                 455                 460                 


Ile Thr Val Ser Gly Cys Ser Arg Glu Asp Val Met Gln Asp Val Asn 
465                 470                 475                 480 


Leu Leu Leu Pro Phe Phe Pro Lys Asn Leu Ile Arg Phe Phe Ser Gly 
                485                 490                 495     


Asp Glu Ser Lys Pro Asp Thr Asp Glu Leu Ala Glu Thr Leu Tyr Ser 
            500                 505                 510         


Arg Ile Arg Ser Asp Trp Asp Arg Ala Ala Asp Phe Ile Asn Arg Leu 
        515                 520                 525             


Asn Val Lys Asn Thr Trp Leu Lys Lys Leu Lys Asn Leu Arg Glu Lys 
    530                 535                 540                 


Asp Ala Asp Ala Lys Leu Pro Pro Pro Val Cys Ser Pro Glu Asp Val 
545                 550                 555                 560 


Lys Asn Pro Pro Arg Ser Cys Asn Ile Ser Asp Gly Thr Met Ile Ala 
                565                 570                 575     


Trp Val Phe Arg Tyr Phe Asn Leu Phe Leu Asp Asp Ser Gln Lys Phe 
            580                 585                 590         


Arg Gln Leu Pro Arg Gly Met Gln His Arg Ser Glu Val Lys Asp His 
        595                 600                 605             


Glu Tyr Gln Leu Val His Ala Met Ile Gly Lys Tyr Ser Met Asp Pro 
    610                 615                 620                 


Lys Ala Leu Gln Ser Tyr Ile His Asn Arg Arg Pro Glu Leu Leu Pro 
625                 630                 635                 640 


Ala Leu Leu Asp Leu Lys Lys Glu Leu Lys Thr Phe Gln Ser Pro Ser 
                645                 650                 655     


Arg Lys Ser Gly Arg Asn Val Arg Gly Tyr Arg Pro Met Met His Ser 
            660                 665                 670         


Leu Ser Asp Leu Ala Lys Ala Ala Ala Asn Cys Tyr Ile Asn Tyr Cys 
        675                 680                 685             


Glu Glu Lys Leu Lys Lys Leu Glu Glu Gly Asn Leu Pro Pro Glu Gly 
    690                 695                 700                 


Ile Leu Ala Leu Cys Lys Lys Phe His Val Arg Thr Gly Leu Pro Tyr 
705                 710                 715                 720 


Asp Arg Thr Ser Leu Leu Lys Thr Val Leu His Ile Asp Leu Gly Lys 
                725                 730                 735     


Trp Ser Ser Ala Phe Asp Tyr Glu Arg Lys Arg Pro Tyr Glu Asn Arg 
            740                 745                 750         


Thr Leu Gln Glu Glu Gly His Ile Val Ser Gln Ile Pro Phe Pro Ala 
        755                 760                 765             


Asp Phe Thr Gln Arg Val Met Gln Gln Thr Lys Asp Glu Arg Trp Lys 
    770                 775                 780                 


Lys Leu Leu His Pro Glu Thr Gly Ile Phe Asp Phe Asn Lys Ala Phe 
785                 790                 795                 800 


Ser Ser Leu Lys Leu Glu Ile Leu Pro Arg Asp Phe Tyr Asp Val Lys 
                805                 810                 815     


Pro Leu Ile Glu Ala Cys Glu Ala Ala Arg Ser Gly Lys Ser Val Ser 
            820                 825                 830         


Gly Ile Ala Gly Leu Asn Ala Ser Thr Pro Glu Lys Pro Leu Asp Phe 
        835                 840                 845             


Ser Arg Ala Gly Ile Asn Arg Ala Ile Arg Glu Ile Lys Glu Thr Gly 
    850                 855                 860                 


Asn Gln Asp Arg Ile Leu Ala Asn Leu Ala Leu Lys Tyr Trp Leu Glu 
865                 870                 875                 880 


Phe Arg Lys Thr Ser Ala Phe Glu Cys Lys Leu Gly Thr Thr Pro Asp 
                885                 890                 895     


Phe Ala Ala Gly Phe Pro Val Asn Glu Phe Phe Lys Ala Glu Val Thr 
            900                 905                 910         


Ile Lys Phe Glu Lys Gly Asp Arg Lys Ile Arg Ile Met Pro Asn Asp 
        915                 920                 925             


Ile Asn Arg Pro Ile Leu Ala Gln Ile Gln Arg Tyr Ala Ser Ala Ile 
    930                 935                 940                 


Ala Asp Ser Met Glu Glu Gly Lys Thr Glu Lys Ser Gln Ile Phe Asp 
945                 950                 955                 960 


Phe Arg Asp Met Leu Val Ala Tyr Arg Lys Ile Gln Ala Asp Asp Ala 
                965                 970                 975     


Arg Lys Arg Lys Glu Ile Ile Pro Leu Leu Arg Lys Phe Glu Ser Ser 
            980                 985                 990         


Val Val Ile Pro Gln Glu Arg Tyr  Asp Ile Lys Ala Glu  Asp Gln Ala 
        995                 1000                 1005             


Glu Lys  Ser Ala Ala Ile Arg  Arg Met Glu Phe Glu  Phe Tyr Arg 
    1010                 1015                 1020             


Lys Lys  Tyr Pro Lys Leu Thr  Phe Lys Glu Tyr Asn  Thr Leu Ala 
    1025                 1030                 1035             


Asp Val  Arg Asn Gln Val Phe  His Arg Gly Phe Arg  Leu Glu Thr 
    1040                 1045                 1050             


Gly Ala  Ala Ile Glu Ile Leu  Lys Ala Tyr Ser Pro  Ser Glu Lys 
    1055                 1060                 1065             


Pro Lys  Thr Glu Asn Gly Asn  Val Tyr Arg Asn Phe  Phe Arg Asn 
    1070                 1075                 1080             


Arg Tyr  Ser Arg Gly Lys Trp  
    1085                 1090 


<210>  2198
<211>  1226
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2198

Met Ser Ser Lys Asn Glu Ser Tyr Asn Lys Gln Lys Thr Phe Asn His 
1               5                   10                  15      


Tyr Lys Gln Glu Asp Lys Tyr Phe Phe Gly Gly Phe Leu Asn Asn Ala 
            20                  25                  30          


Asp Asp Asn Leu Arg Gln Val Gly Lys Glu Phe Lys Thr Arg Ile Asn 
        35                  40                  45              


Phe Asn His Asn Asn Asn Glu Leu Ala Ser Val Phe Lys Asp Tyr Phe 
    50                  55                  60                  


Asn Lys Glu Lys Ser Val Ala Lys Arg Glu His Ala Leu Asn Leu Leu 
65                  70                  75                  80  


Ser Asn Tyr Phe Pro Val Leu Glu Arg Ile Gln Lys His Thr Asn His 
                85                  90                  95      


Asn Phe Glu Gln Thr Arg Glu Ile Phe Glu Leu Leu Leu Asp Thr Ile 
            100                 105                 110         


Lys Lys Leu Arg Asp Tyr Tyr Thr His His Tyr His Lys Pro Ile Thr 
        115                 120                 125             


Ile Asn Pro Lys Ile Tyr Asp Phe Leu Asp Asp Thr Leu Leu Asp Val 
    130                 135                 140                 


Leu Ile Thr Ile Lys Lys Lys Lys Val Lys Asn Asp Thr Ser Arg Glu 
145                 150                 155                 160 


Leu Leu Lys Glu Lys Leu Arg Pro Glu Leu Thr Gln Leu Lys Asn Gln 
                165                 170                 175     


Lys Arg Glu Glu Leu Ile Lys Lys Gly Lys Lys Leu Leu Glu Glu Asn 
            180                 185                 190         


Leu Glu Asn Ala Val Phe Asn His Cys Leu Ile Pro Phe Leu Glu Glu 
        195                 200                 205             


Asn Lys Thr Asp Asp Lys Gln Asn Lys Thr Val Ser Leu Arg Lys Tyr 
    210                 215                 220                 


Arg Lys Ser Lys Pro Asn Glu Glu Thr Ser Ile Thr Leu Thr Gln Ser 
225                 230                 235                 240 


Gly Leu Val Phe Leu Met Ser Phe Phe Leu His Arg Lys Glu Phe Gln 
                245                 250                 255     


Val Phe Thr Ser Gly Leu Glu Gly Phe Lys Ala Lys Val Asn Thr Ile 
            260                 265                 270         


Lys Glu Glu Glu Ile Ser Leu Asn Lys Asn Asn Ile Val Tyr Met Ile 
        275                 280                 285             


Thr His Trp Ser Tyr Ser Tyr Tyr Asn Phe Lys Gly Leu Lys His Arg 
    290                 295                 300                 


Ile Lys Thr Asp Gln Gly Val Ser Thr Leu Glu Gln Asn Asn Thr Thr 
305                 310                 315                 320 


His Ser Leu Thr Asn Thr Asn Thr Lys Glu Ala Leu Leu Thr Gln Ile 
                325                 330                 335     


Val Asp Tyr Leu Ser Lys Val Pro Asn Glu Ile Tyr Glu Thr Leu Ser 
            340                 345                 350         


Glu Lys Gln Gln Lys Glu Phe Glu Glu Asp Ile Asn Glu Tyr Met Arg 
        355                 360                 365             


Glu Asn Pro Glu Asn Glu Asp Ser Thr Phe Ser Ser Ile Val Ser His 
    370                 375                 380                 


Lys Val Ile Arg Lys Arg Tyr Glu Asn Lys Phe Asn Tyr Phe Ala Met 
385                 390                 395                 400 


Arg Phe Leu Asp Glu Tyr Ala Glu Leu Pro Thr Leu Arg Phe Met Val 
                405                 410                 415     


Asn Phe Gly Asp Tyr Ile Lys Asp Arg Gln Lys Lys Ile Leu Glu Ser 
            420                 425                 430         


Ile Gln Phe Asp Ser Glu Arg Ile Ile Lys Lys Glu Ile His Leu Phe 
        435                 440                 445             


Glu Lys Leu Gly Leu Val Thr Glu Tyr Lys Lys Asn Val Tyr Leu Lys 
    450                 455                 460                 


Glu Thr Ser Asn Ile Asp Leu Ser Arg Phe Pro Leu Phe Pro Asn Pro 
465                 470                 475                 480 


Ser Tyr Val Met Ala Asn Asn Asn Ile Pro Phe Tyr Ile Asp Ser Arg 
                485                 490                 495     


Ser Asn Asn Leu Asp Glu Tyr Leu Asn Gln Lys Lys Lys Ala Gln Ser 
            500                 505                 510         


Gln Asn Arg Lys Arg Asn Leu Thr Phe Glu Lys Tyr Asn Lys Glu Gln 
        515                 520                 525             


Ser Lys Asp Ala Ile Ile Ala Met Leu Gln Lys Glu Ile Gly Val Lys 
    530                 535                 540                 


Asp Leu Gln Gln Arg Ser Thr Ile Gly Leu Leu Ser Cys Asn Glu Leu 
545                 550                 555                 560 


Pro Ser Met Leu Tyr Glu Val Ile Val Lys Asp Ile Lys Gly Ala Glu 
                565                 570                 575     


Leu Glu Asn Lys Ile Ala Gln Lys Ile Arg Glu Gln Tyr Gln Ser Ile 
            580                 585                 590         


Arg Asp Phe Thr Leu Asp Ser Pro Gln Lys Asp Asn Ile Pro Thr Thr 
        595                 600                 605             


Leu Ile Lys Thr Ile Asn Thr Asp Ser Ser Val Thr Phe Glu Asn Gln 
    610                 615                 620                 


Pro Ile Asp Ile Pro Arg Leu Lys Asn Ala Ile Gln Lys Glu Leu Ala 
625                 630                 635                 640 


Leu Thr Gln Glu Lys Leu Leu Asn Val Lys Glu His Glu Ile Glu Val 
                645                 650                 655     


Asp Asn Tyr Asn Arg Asn Lys Asn Thr Tyr Lys Phe Lys Asn Gln Pro 
            660                 665                 670         


Lys Asn Lys Val Asp Asp Lys Lys Leu Gln Arg Lys Tyr Val Phe Tyr 
        675                 680                 685             


Arg Asn Glu Ile Arg Gln Glu Ala Asn Trp Leu Ala Ser Asp Leu Ile 
    690                 695                 700                 


His Phe Met Lys Asn Lys Ser Leu Trp Lys Gly Tyr Met His Asn Glu 
705                 710                 715                 720 


Leu Gln Ser Phe Leu Ala Phe Phe Glu Asp Lys Lys Asn Asp Cys Ile 
                725                 730                 735     


Ala Leu Leu Glu Thr Val Phe Asn Leu Lys Glu Asp Cys Ile Leu Thr 
            740                 745                 750         


Lys Gly Leu Lys Asn Leu Phe Leu Lys His Gly Asn Phe Ile Asp Phe 
        755                 760                 765             


Tyr Lys Glu Tyr Leu Lys Leu Lys Glu Asp Phe Leu Asn Thr Glu Ser 
    770                 775                 780                 


Thr Phe Leu Glu Asn Gly Phe Ile Gly Leu Pro Pro Lys Ile Leu Lys 
785                 790                 795                 800 


Lys Glu Leu Ser Lys Arg Leu Lys Tyr Ile Phe Ile Val Phe Gln Lys 
                805                 810                 815     


Arg Gln Phe Ile Ile Lys Glu Leu Glu Glu Lys Lys Asn Asn Leu Tyr 
            820                 825                 830         


Ala Asp Ala Ile Asn Leu Ser Arg Gly Ile Phe Asp Glu Lys Pro Thr 
        835                 840                 845             


Met Ile Pro Phe Lys Lys Pro Asn Pro Asp Glu Phe Ala Ser Trp Phe 
    850                 855                 860                 


Val Ala Ser Tyr Gln Tyr Asn Asn Tyr Gln Ser Phe Tyr Glu Leu Thr 
865                 870                 875                 880 


Pro Asp Ile Val Glu Arg Asp Lys Lys Lys Lys Tyr Lys Asn Leu Arg 
                885                 890                 895     


Ala Ile Asn Lys Val Lys Ile Gln Asp Tyr Tyr Leu Lys Leu Met Val 
            900                 905                 910         


Asp Thr Leu Tyr Gln Asp Leu Phe Asn Gln Pro Leu Asp Lys Ser Leu 
        915                 920                 925             


Ser Asp Phe Tyr Val Ser Lys Ala Glu Arg Glu Lys Ile Lys Ala Asp 
    930                 935                 940                 


Ala Lys Ala Tyr Gln Lys Arg Asn Asp Ser Ser Leu Trp Asn Lys Val 
945                 950                 955                 960 


Ile His Leu Ser Leu Gln Asn Asn Arg Ile Thr Ala Asn Pro Lys Leu 
                965                 970                 975     


Lys Asp Ile Gly Lys Tyr Lys Arg Ala Leu Gln Asp Glu Lys Ile Ala 
            980                 985                 990         


Thr Leu Leu Thr Tyr Asp Ala Arg  Thr Trp Thr Tyr Ala  Leu Gln Lys 
        995                 1000                 1005             


Pro Glu  Lys Glu Asn Glu Asn  Asp Tyr Lys Glu Leu  His Tyr Thr 
    1010                 1015                 1020             


Ala Leu  Asn Met Glu Leu Gln  Glu Tyr Glu Lys Val  Arg Ser Lys 
    1025                 1030                 1035             


Glu Leu  Leu Lys Gln Val Gln  Glu Leu Glu Lys Lys  Ile Leu Asp 
    1040                 1045                 1050             


Lys Phe  Tyr Asp Phe Ser Asn  Asn Ala Ser His Pro  Glu Asp Leu 
    1055                 1060                 1065             


Glu Ile  Glu Asp Lys Lys Gly  Lys Arg His Pro Asn  Phe Lys Leu 
    1070                 1075                 1080             


Tyr Ile  Thr Lys Ala Leu Leu  Lys Asn Glu Ser Glu  Ile Ile Asn 
    1085                 1090                 1095             


Leu Glu  Asn Ile Asp Ile Glu  Ile Leu Leu Lys Tyr  Tyr Asp Tyr 
    1100                 1105                 1110             


Asn Thr  Glu Glu Leu Lys Glu  Lys Ile Lys Asn Met  Asp Glu Asp 
    1115                 1120                 1125             


Glu Lys  Ala Lys Ile Ile Asn  Thr Lys Glu Asn Tyr  Asn Lys Ile 
    1130                 1135                 1140             


Thr Asn  Val Leu Ile Lys Lys  Ala Leu Val Leu Ile  Ile Ile Arg 
    1145                 1150                 1155             


Asn Lys  Met Ala His Asn Gln  Tyr Pro Pro Lys Phe  Ile Tyr Asp 
    1160                 1165                 1170             


Leu Ala  Thr Ser Phe Gln Asn  Asp Lys Arg Asn Lys  Asp Trp Glu 
    1175                 1180                 1185             


Lys Phe  Val His Gln Lys Glu  Ser Glu Tyr Phe Ala  Thr Tyr Phe 
    1190                 1195                 1200             


Asn Arg  Val Phe Glu Thr Ile  Thr Lys Glu Leu Trp  Glu Asn Lys 
    1205                 1210                 1215             


Glu Lys  Lys Asp Lys Thr Gln  Val 
    1220                 1225     


<210>  2199
<211>  1331
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2199

Met Gly Lys Asp Asn Lys Lys Tyr Gln Ala Lys Gly Gln Asp Gln Lys 
1               5                   10                  15      


Pro Arg Gln Thr Lys Lys Val Arg Arg Ile Gln Ser Lys Asp Phe Arg 
            20                  25                  30          


Ile Ser Leu Thr Gly Lys His Val Phe Gly Ala Tyr Phe Asn Met Ala 
        35                  40                  45              


Arg Thr Asn Phe Val Lys Thr Ile Asn Tyr Val Leu Pro Ile Ala Gly 
    50                  55                  60                  


Val Arg Gly Asn Tyr Ser Glu Asn Gln Ile Asn Lys Met Leu Gln Ala 
65                  70                  75                  80  


Leu Phe Leu Ile Gln Ser Asn Arg Ser Ala Glu Leu Thr Gln Glu Gln 
                85                  90                  95      


Gln Gln Trp Lys Lys Lys Leu Thr Leu Thr Ser Glu Gln Gln Thr Arg 
            100                 105                 110         


Leu Gln Arg Leu Leu Phe Lys His Phe Pro Val Leu Gly Pro Met Met 
        115                 120                 125             


Ala Asp Val Ala Asp His Lys Ala Tyr Leu Asn Lys Lys Lys Ser Lys 
    130                 135                 140                 


Val Gln Thr Glu Asp Glu Ala Phe Glu Gln Leu Arg Gly Val Ser Leu 
145                 150                 155                 160 


Ala Asp Cys Leu Glu Ile Leu Val Leu Met Gly Met Thr Leu Thr Glu 
                165                 170                 175     


Cys Arg Asn Phe Tyr Thr His Arg Arg Pro Tyr Asn Ser Pro Ser Glu 
            180                 185                 190         


Leu Ala Gly Gln Tyr Ser His Gln Ala Thr Ile Ala Lys Lys Leu Asp 
        195                 200                 205             


Lys Val Val Val Ala Ser Arg Arg Ile Leu Lys Asp Arg Glu Gly Leu 
    210                 215                 220                 


Ser Val Asn Glu Ile Glu Phe Leu Thr Gly Ile Asp His Met Glu Gln 
225                 230                 235                 240 


Val Asp Val Leu Asp Glu Asn Gly Lys Pro Lys Met Val Asn Gly Lys 
                245                 250                 255     


Lys Met Lys Ser Phe Lys Glu Tyr Asp Asp Phe Tyr Phe Thr Leu Trp 
            260                 265                 270         


Ala Lys Arg Asp Val Lys Asn Ile Thr Met Thr Gly Ser Asp Gly His 
        275                 280                 285             


Pro Thr Thr Ile Asp Thr Lys Leu Pro Ala Leu Ser Asp Phe Gly Leu 
    290                 295                 300                 


Leu Tyr Phe Cys Val Leu Phe Leu Ser Lys Pro Tyr Ala Lys Leu Phe 
305                 310                 315                 320 


Met Asp Glu Ala Arg Leu Phe Glu Phe Ser Pro Phe Thr Gly Gln Glu 
                325                 330                 335     


Asn Ile Ile Met Gln Glu Met Leu Cys Ile Tyr Arg Ile Arg Thr Pro 
            340                 345                 350         


Gln Leu His Arg Ile Asp Ser Arg Asp Ser Lys Ala Thr Leu Ala Met 
        355                 360                 365             


Asp Ile Phe Gly Glu Leu Arg Arg Cys Pro Thr Glu Leu Tyr Asp Leu 
    370                 375                 380                 


Leu Asp Lys Thr Ala Gly Gln Pro Phe Phe His Asp Val Val Lys Arg 
385                 390                 395                 400 


Pro Asn Ala Phe Thr Pro Glu Val Ser Lys Arg Leu Arg Tyr Thr Asp 
                405                 410                 415     


Arg Phe Pro Gln Leu Ala Leu Arg Tyr Ile Asp Gln Asn Asp Leu Phe 
            420                 425                 430         


Lys Arg Ile Arg Phe Gln Leu Gln Leu Gly Ala Phe Arg Tyr Lys Phe 
        435                 440                 445             


Tyr Asp Lys Thr Asp Cys Val Asp Gly Arg Val Arg Val Arg Arg Ile 
    450                 455                 460                 


Gln Lys Asp Ile Asn Gly Tyr Gly Arg Pro Gln Glu Val Asn Glu Lys 
465                 470                 475                 480 


Arg Phe Lys Thr Trp Glu Gly Leu Ile Gln Lys Arg Glu Glu Arg Ser 
                485                 490                 495     


Val Lys Leu Glu His Glu Glu Leu Tyr Ile Asp Leu Asp Gln Phe Gln 
            500                 505                 510         


Gln Asp Thr Ala Ala Ser Thr Pro Tyr Val Thr Asp Arg Arg Pro Ser 
        515                 520                 525             


Tyr Asn Ile His Ala Asn Arg Ile Gly Met Tyr Trp Glu Glu Ser Gln 
    530                 535                 540                 


Asn Pro Asn Gln Phe Lys Tyr Phe Asp Glu Lys Lys Ile Tyr Ile Pro 
545                 550                 555                 560 


Glu Leu Lys Val Thr Glu Asp Gly Lys Ala Pro Ile Glu Met Pro Val 
                565                 570                 575     


Pro Arg Cys Ser Leu Ser Val Tyr Asp Leu Ala Gly Met Leu Phe Tyr 
            580                 585                 590         


Glu Tyr Leu Leu Lys Arg Ser Asp Ser Lys Tyr Pro Ser Ala Glu Gln 
        595                 600                 605             


Ile Ile Ile Asp Cys Glu Ser Asp Tyr His Arg Phe Phe Ser Ala Val 
    610                 615                 620                 


Ala Asp Gly Thr Leu Lys Pro Phe Ala Lys Gln Lys Glu Leu Cys Asp 
625                 630                 635                 640 


Tyr Leu Ala Thr Asn Tyr Pro Asn Leu Arg Leu Ala Asp Ile Pro Glu 
                645                 650                 655     


Lys Leu Leu Leu Phe Leu Ser Gly Lys Gly Leu Thr His Asn Asn Met 
            660                 665                 670         


Pro Glu Thr Ala Arg Gln Arg Leu Val Arg Leu Thr Ile Glu His Leu 
        675                 680                 685             


Glu Glu Arg Glu Gln Arg Val Gln Arg Arg Leu Asp His Tyr Glu Glu 
    690                 695                 700                 


Asp Arg Lys Lys Ile Gly Asp Lys Glu Asn Lys Tyr Gly Lys Lys Gly 
705                 710                 715                 720 


Phe Ala Asp Val Arg His Gly Ala Leu Ala Arg Tyr Leu Ala Gln Ser 
                725                 730                 735     


Met Met Glu Trp Gln Pro Thr Lys Asp Gly Met Gly His Asp Lys Leu 
            740                 745                 750         


Thr Gly Leu Asn Tyr Asn Val Leu Thr Ala Tyr Leu Ala Thr Phe Gly 
        755                 760                 765             


Ala Pro Gln Pro Ala Asp Glu Pro Asp Phe Ala Pro Leu Ser Leu Gln 
    770                 775                 780                 


Glu Val Leu Ala Lys Ala His Leu Ile Gly Gly Ser Asn Pro His Pro 
785                 790                 795                 800 


Phe Leu Pro Lys Val Leu Ser His Thr Ile Thr Val Asn Arg Gln Thr 
                805                 810                 815     


Asp Arg Lys Met Thr Val Glu Pro Arg Asn Ile Glu Glu Phe Tyr Leu 
            820                 825                 830         


Phe Tyr Leu Glu Glu Glu Leu Lys His Ile Arg Ser Arg Met Gln Ser 
        835                 840                 845             


Leu Lys Thr Asn Ala Ser Asp Lys Ala Leu Ala Ser Leu Pro Phe Val 
    850                 855                 860                 


His His Asp Arg Met Arg Phe Arg Glu Arg Thr Ala Glu Glu Met Lys 
865                 870                 875                 880 


Ala Leu Ala Ser Arg Tyr Thr Thr Ile Gln Leu Pro Asp Gly Leu Phe 
                885                 890                 895     


Thr Pro His Ile Leu Lys Leu Leu Arg Ala Glu Tyr Ala Asp Asn Glu 
            900                 905                 910         


Ala Leu Gln Gln Ala Leu Asn Leu Gln Met Pro Asn Gln Leu Asn Pro 
        915                 920                 925             


Val Asn Asn Ala Ala Tyr Leu Ile Thr Leu Phe Tyr Gln Thr Val Leu 
    930                 935                 940                 


His Asp Asp Ala Gln Pro Phe Tyr Met Ser Ala Lys Ala Tyr Thr Arg 
945                 950                 955                 960 


Gln Asn Ala Asp Asn Lys Thr Glu Thr Phe Ser Phe Lys Arg Ala Tyr 
                965                 970                 975     


Glu Leu Phe Thr Ile Leu Ala Asp Asp Lys Glu Asn Phe Phe Pro Phe 
            980                 985                 990         


Glu Leu Lys Pro Leu Phe Leu Thr  Ser Asp Asp Ile Gln  Ala Arg Ile 
        995                 1000                 1005             


Ser Ala  Lys Val Lys Asp Glu  Thr Gly Asp Pro Ile  Ala Lys Ile 
    1010                 1015                 1020             


Gly Lys  Arg Gly Lys Lys Glu  Lys Asp Ser Gln Gly  Asn Ile Ile 
    1025                 1030                 1035             


Trp Leu  Arg Glu Ile Thr Glu  Lys Ile Asp Val Tyr  Val Asp Ser 
    1040                 1045                 1050             


Arg Thr  Asp Lys Asp Leu Lys  Ile Ser Ala Asn Gln  Ser Arg Lys 
    1055                 1060                 1065             


Glu Lys  Glu Ala Glu Arg Glu  Gln Lys Arg Glu Ala  Leu Arg Leu 
    1070                 1075                 1080             


Arg Leu  Asn Arg Met Val Arg  Glu Val Lys Asp Asn  Glu Arg Thr 
    1085                 1090                 1095             


Leu Arg  Arg Phe Lys Thr Gln  Asp Met Val Leu Phe  Leu Met Ala 
    1100                 1105                 1110             


Lys Asp  Met Phe Thr Asn Ile  Leu Ser Asp Gln Glu  Arg Glu Val 
    1115                 1120                 1125             


Asn Trp  Lys His Leu Arg Leu  Ser Lys Val Cys Asn  Glu Ala Phe 
    1130                 1135                 1140             


Leu Arg  Gln Thr Leu Thr Phe  Leu Ile Pro Val Thr  Ile Gly Asp 
    1145                 1150                 1155             


Val Thr  Ile Tyr Val Glu Gln  Glu Asn Met Ser Leu  Lys Asn Tyr 
    1160                 1165                 1170             


Gly Glu  Phe Tyr Arg Phe Leu  Thr Asp Asp Arg Leu  Thr Ser Leu 
    1175                 1180                 1185             


Leu Glu  Asn Ile Val Gly Asp  Leu Glu Pro Asp Gln  Gln Gly Arg 
    1190                 1195                 1200             


Leu Val  Ile Arg His Thr Asp  Leu Met Ser Glu Leu  Ala Ala Tyr 
    1205                 1210                 1215             


Asp Gln  Lys Arg Ser Thr Val  Phe Lys Leu Ile Gln  Gln Ile Glu 
    1220                 1225                 1230             


Ala Leu  Ile Ile Lys Ser Asn  Asp Ala Leu Ser Asn  Pro Ala Ser 
    1235                 1240                 1245             


Pro Asp  Phe Trp Ala Lys Pro  Gly Leu Pro Lys Arg  Asn Asn Phe 
    1250                 1255                 1260             


Ala Ser  Leu Leu Glu Leu Ile  Asp His Leu Asn Gln  Thr Ala Leu 
    1265                 1270                 1275             


Thr Thr  Glu Glu Arg Thr Leu  Leu Val Ala Ile Arg  Asn Ala Phe 
    1280                 1285                 1290             


Ser His  Asn Ser Tyr Asn Leu  Asp Leu Thr Gln Ile  Ala Gly Val 
    1295                 1300                 1305             


Lys His  Leu Pro Glu Val Ala  Asn Ser Ile Leu Lys  His Leu Glu 
    1310                 1315                 1320             


Thr Ile  Met Gly Glu Thr Gln  Lys 
    1325                 1330     


<210>  2200
<211>  1160
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2200

Met Glu Gln Lys Gln Leu Glu Ser Arg Phe Asn Gln Ile Phe Asn Asn 
1               5                   10                  15      


Lys Gly His Thr Gly Pro Ile Ala Glu Lys Ala Val Lys Asn Phe Glu 
            20                  25                  30          


Thr Ile Arg Gln His Lys Val Ser Pro Arg Glu Arg Leu His Tyr Phe 
        35                  40                  45              


Ala Val Gly His Ala Leu Arg Asn Ile Asp Lys Asp Leu Lys Glu Ser 
    50                  55                  60                  


Ile Phe Glu Tyr Asn Leu Asp Glu Glu Gln Lys Lys Gln Lys Pro Thr 
65                  70                  75                  80  


Gln Phe Thr Thr Leu Gln Ser Asp Phe Phe Arg Phe Glu Asn Ala Leu 
                85                  90                  95      


Leu Thr Leu Leu Lys Asp Ile Arg Asn Cys Asn Gly His Tyr Val His 
            100                 105                 110         


Thr Phe Asp Lys Leu Gln Leu Asp Glu Ile Leu Lys Leu Gln Glu Lys 
        115                 120                 125             


Asn Lys Glu His Gly Ile Leu Asn Lys Asp Ala Gly Cys Gln Ile Ile 
    130                 135                 140                 


Glu Phe Leu Lys Glu Ala Phe Glu Phe Ser Ile Leu Ile Gln Phe Leu 
145                 150                 155                 160 


Lys Glu Lys Pro Lys Glu Tyr Glu Lys Phe Lys Lys Arg Lys Asn Glu 
                165                 170                 175     


Asn Lys Asn Gln Ser Leu Arg Asn Leu Ile Gly Gly Tyr Glu Lys Lys 
            180                 185                 190         


Leu Val Lys Tyr Leu Cys Asp Lys Phe Phe Pro Asn Glu Glu Lys Gln 
        195                 200                 205             


Lys Glu Ile Arg Asp Lys Phe Ile Glu His Asn Leu Glu Glu Ala Ile 
    210                 215                 220                 


Glu Asp Leu Leu Phe Ile Pro Val Asp Glu Asp Ile Glu Trp Lys Leu 
225                 230                 235                 240 


Gly Glu Glu His Val Val Phe Val Ile Lys Lys Gly Lys Tyr Leu Ser 
                245                 250                 255     


Phe Tyr Ala Gln Leu Phe Leu Leu Ser Met Phe Leu Tyr Lys Gln Glu 
            260                 265                 270         


Ala Asn Gln Leu Ile Ser Lys Ile Arg Gly Phe Lys Arg Ser Glu Asp 
        275                 280                 285             


Glu Phe Gln Tyr Lys Arg Asn Ile Phe Thr Phe Phe Ser Lys Lys Val 
    290                 295                 300                 


Ser Ser Gln Asp Ile His Ser Glu Glu Lys His Leu Ile Tyr Phe Arg 
305                 310                 315                 320 


Asp Ile Ile Gln Tyr Leu Asn Arg Phe Pro Thr Ala Trp Asn Glu Tyr 
                325                 330                 335     


Leu Ser Pro Glu Arg Lys Asn Leu Pro Met Thr Lys Leu Leu Glu Lys 
            340                 345                 350         


Tyr Ile Leu Glu Glu Glu Ile Phe Arg Thr Phe Ser Thr Tyr Lys Asn 
        355                 360                 365             


Asp Cys Asn Arg Glu Leu Phe Leu Lys Tyr Thr Ile Lys Arg Leu Phe 
    370                 375                 380                 


Cys Lys Lys Ala Glu Leu Phe Asp Ala Glu Lys Ile Ser Ile Asp Asp 
385                 390                 395                 400 


Asn Leu Arg Lys Lys Phe Asn Tyr Glu Ile Asp Thr Ser Pro Glu Leu 
                405                 410                 415     


Lys Asn Ile His Glu Lys Leu Lys Gly Lys Leu Lys Pro Lys Asp Tyr 
            420                 425                 430         


Tyr Lys Asn Ile Lys Arg Lys Glu Glu Leu Glu Lys Glu Glu Asn Pro 
        435                 440                 445             


Glu Lys Leu Lys Leu Thr Lys Lys Val Thr Glu Glu Lys Leu Phe Thr 
    450                 455                 460                 


Ala Tyr Gly Arg Asn Arg Asp Arg Phe Met Asp Phe Ala Val Arg Tyr 
465                 470                 475                 480 


Leu Ala Glu Gln Asn Tyr Phe Gly Lys Asp Ala Glu Phe Lys Met Tyr 
                485                 490                 495     


Met Phe Glu Thr Thr Asn Glu Gln Glu Asn Tyr Leu Lys Glu Gln Lys 
            500                 505                 510         


Asn Thr Ala Asp Lys Lys Val Ile Asp Gln Asn Lys Tyr His Gln Gly 
        515                 520                 525             


Arg Leu Thr Cys Phe Lys Thr Tyr Gln Lys His Lys Asp Asp Tyr Gln 
    530                 535                 540                 


Asn Trp Asp Asp Pro Phe Val Phe Gln Asn Asn Ala Phe Gln Ile Ile 
545                 550                 555                 560 


Leu Thr Phe Ser Asn Gly Glu Arg Lys Lys Phe Ser Ile Gln Arg Lys 
                565                 570                 575     


Leu Leu Ile Tyr Leu Leu Glu Asp Ala Leu Phe Asn His Ser Asp Ser 
            580                 585                 590         


Ile Glu Asp Lys Gly Lys Gln Leu Leu Glu Asp Tyr Phe Phe Asn Thr 
        595                 600                 605             


Leu Met Pro Asp Phe Glu Asp Ala Lys Glu Ser Tyr Lys Thr Ser Asp 
    610                 615                 620                 


Asp Val Asn Trp Lys His Arg Lys Leu Leu Pro Lys Arg Leu Ile Tyr 
625                 630                 635                 640 


Thr Val His Pro Pro Arg Arg Thr Asp Ser Glu Glu Gln Ile His Pro 
                645                 650                 655     


Phe Glu Lys Ile Leu Arg Glu Thr Gln Glu Gln Glu Arg Arg Tyr Arg 
            660                 665                 670         


Leu Leu Leu Gly Lys Ala Lys Asn Met Lys Leu Lys Glu Glu Phe Ile 
        675                 680                 685             


Lys Arg Asn Lys Gly Lys His Phe Lys Leu Arg Phe Ile Arg Lys Ala 
    690                 695                 700                 


Trp His Leu Met Tyr Phe Arg Glu Ile Tyr Glu Arg Arg Ala Lys Glu 
705                 710                 715                 720 


His Ser His His Lys Ser Phe His Ile Thr Arg Asp Glu Ile Asn Asp 
                725                 730                 735     


Phe Ser Arg Trp Met Tyr Ala Phe Asp Glu Val Pro Pro Tyr Lys Val 
            740                 745                 750         


Tyr Leu Arg Asn Met Leu Gln Arg Lys Lys Phe Met Glu Asn Glu Glu 
        755                 760                 765             


Phe Ala Glu Leu Phe Glu Lys Gly Lys Ser Leu Asp Asp Phe Tyr Arg 
    770                 775                 780                 


Ile Thr Lys Lys Glu Phe Ser Lys Arg Ile Lys Asn Asn Leu Phe Gln 
785                 790                 795                 800 


Leu Lys Val Asp Ser Glu Arg Gln Tyr Ala Glu Ile Leu Ser Lys Lys 
                805                 810                 815     


Leu Val Tyr Ile Asn Leu Ser His Phe Ile Lys Tyr Leu Asn Ala Lys 
            820                 825                 830         


Gly Lys Leu Thr Val Glu Asn Gly Ile Ile Gln Tyr Lys Ala Ser Thr 
        835                 840                 845             


Asn Lys Lys Tyr Leu Ile Asp Glu Tyr Tyr Tyr Thr Glu Val Leu Pro 
    850                 855                 860                 


Arg Glu Glu Tyr Lys Val His Lys His Leu Phe Asn Lys Leu Arg Ala 
865                 870                 875                 880 


Thr Lys Leu Glu Asp Ala Leu Leu Tyr Glu Leu Ala Met Lys Tyr Leu 
                885                 890                 895     


Arg Glu Asp Asn Asp Ile Val Glu Lys Ala Lys Ser Lys Val Ser Asp 
            900                 905                 910         


Ile Gln Ser Ser Glu Ile Ser Phe Asp Ile Lys Asp Tyr Tyr Gly Asn 
        915                 920                 925             


His Leu Tyr Thr Leu Ile Val Pro Phe Asn Lys Leu Glu Thr Leu Ser 
    930                 935                 940                 


Ile Leu Ile Arg Tyr Lys Thr Lys Gln Glu Lys Asn Ser Lys Leu Gln 
945                 950                 955                 960 


Arg Thr Ser Phe Leu Gly Asn Ile Tyr His Leu Leu Ala Phe Leu Asp 
                965                 970                 975     


Lys Asn Tyr Lys Gln Leu Ser Lys Tyr Lys Asp Asp Gly Gly Phe Lys 
            980                 985                 990         


Lys Ile Val Lys Asn Phe Lys Asn  Lys Lys Arg Leu Ser  Phe Val Glu 
        995                 1000                 1005             


Leu Asn  Thr Ile Asn Gly Tyr  Ile Ile Ser Gly Ala  Val Lys Phe 
    1010                 1015                 1020             


Ser Lys  Val His Met Glu Leu  Glu Arg Tyr Phe Ile  Asn Lys His 
    1025                 1030                 1035             


Lys Ile  Lys Ala Asn His Ile  Tyr Ile Asp Leu Glu  Asp Ile Lys 
    1040                 1045                 1050             


Asp Asp  Ser Asn Lys Gln Val  Phe Gly Asn Tyr Tyr  Asp Ser Lys 
    1055                 1060                 1065             


Leu Arg  Ile Arg Asn Lys Ala  Phe His Phe Gly Val  Pro Thr Asn 
    1070                 1075                 1080             


Phe Phe  Phe Asn Ile Glu Ile  Glu Lys Ile Glu Lys  Lys Phe Ile 
    1085                 1090                 1095             


Leu Glu  Glu Val Lys Leu Gln  Asn Val Ser Ser Phe  Asp Lys Leu 
    1100                 1105                 1110             


Asn Gln  Asn Ala Lys Ser Val  Cys Arg Val Phe Met  Glu Val Leu 
    1115                 1120                 1125             


His Ser  Asp Leu Tyr Arg Arg  Asp Lys Asn Lys Ser  Lys Glu Glu 
    1130                 1135                 1140             


Leu Arg  Arg Glu Phe Glu Glu  Lys Tyr Phe Asn Glu  Ile Ile Thr 
    1145                 1150                 1155             


Thr Val  
    1160 


<210>  2201
<211>  1232
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2201

Met Thr Thr Thr Ser Leu Asn Asn Ala Arg Leu Ala Leu Tyr Leu Asn 
1               5                   10                  15      


Gln Ala Glu His Asn Ala Phe Met Ile Ile Lys Glu Val Phe Arg Lys 
            20                  25                  30          


Met Asp Ala Asp Lys Gln Asn Tyr Val Asp Gly Glu Ile Gly Leu Ala 
        35                  40                  45              


Lys Lys Phe Tyr Lys Ile Ala His Gly Tyr Tyr Asp Lys Arg Leu Glu 
    50                  55                  60                  


Leu Gln Arg Met Leu Glu Leu Leu Gln Phe Tyr Phe Pro Phe Met Glu 
65                  70                  75                  80  


Met Leu Ala Lys Asp Ala Pro Asp Pro Glu Lys Ala Gln Ile Glu Lys 
                85                  90                  95      


Leu Thr Leu Met Leu Ile Val Leu Asn Thr Phe Arg Asn His Tyr Ser 
            100                 105                 110         


His Tyr Thr Thr His Pro Ser Ile Leu His Asp Gly Phe Leu Lys Arg 
        115                 120                 125             


Asp Phe Lys Lys Asp Lys Asn Gly Asp Pro Asn Ala Asp Phe His Gly 
    130                 135                 140                 


Val Leu Leu Tyr Asp Lys Glu Gly Lys Glu Lys His Phe Asn Gly Arg 
145                 150                 155                 160 


Asn Ile Leu Phe Glu Val Arg Lys Ala Thr Asn Thr Leu Tyr Lys Lys 
                165                 170                 175     


Ala Val Glu Glu Lys Met Arg Val Glu Tyr Phe Lys His Ser Asp Glu 
            180                 185                 190         


Asn Arg Ser Thr Ser Lys Lys Asp Tyr Lys Tyr Ile Asp Lys Leu Asn 
        195                 200                 205             


Glu Ile Glu Thr Ile Phe Leu Pro Leu Leu Lys Ile Glu Lys Arg Ala 
    210                 215                 220                 


Asp Gly Asn Glu Asn Lys Glu Val Pro Glu Leu Ser Gln Leu Phe Lys 
225                 230                 235                 240 


Thr Thr Arg Glu Asp Arg Lys Asp Thr Ala Gly Lys Val Ile Arg Asp 
                245                 250                 255     


Glu Lys Thr Gly Lys Ala Arg Pro Tyr Phe Lys Ile Glu Lys Ile Asn 
            260                 265                 270         


Ser Asp Gly Leu Leu Tyr Phe Ile Cys Leu Phe Leu Asn Ser Gly Asp 
        275                 280                 285             


Ala Asn Arg Leu Ile Ser Gly Thr Thr Gly Phe Lys Arg Asn Asp Asp 
    290                 295                 300                 


Leu Val Trp Glu Ser Lys Arg Leu Ala Phe Arg His Phe Cys Cys Lys 
305                 310                 315                 320 


Pro Pro His Ser Arg Leu Arg Ser Ile Ser Met Thr Asp Asp Ser Leu 
                325                 330                 335     


Leu Leu Asp Ile Ile Gly Glu Leu Gln Lys Cys Pro Ala Glu Ile Tyr 
            340                 345                 350         


Pro Leu Leu Asp Asp Glu Tyr Arg Gln Lys Phe Arg Phe Gly Thr Asp 
        355                 360                 365             


Val Tyr Leu Asn Asn Asn Glu Glu Lys Val Glu Asn Glu Ser Leu Gln 
    370                 375                 380                 


Lys Arg Tyr Glu Asn Arg Phe Pro Tyr Leu Ala Leu Arg Tyr Leu Asp 
385                 390                 395                 400 


Ser Leu Asn Leu Pro Asn Leu Arg Phe Gln Leu Thr Leu Gly Lys Val 
                405                 410                 415     


Asn Met Lys Lys Tyr Glu Lys Arg Phe Met Asp Glu Ile Ile Asp Arg 
            420                 425                 430         


Gln Leu Gln Lys Glu Val Lys Val Phe Asp Arg Leu Cys Asn Tyr Pro 
        435                 440                 445             


Tyr Glu Asn Asp Val Asp Glu Asn Gly Ile Ile Thr Arg Gln Ala Val 
    450                 455                 460                 


Ser Lys Leu Ile Glu Glu Ser Leu Lys Gly Thr Ser Leu Asp Lys Asn 
465                 470                 475                 480 


Ser Leu Leu Leu Asn Glu Trp Glu Glu Asp Gly Ile Leu Ser Asn Asn 
                485                 490                 495     


Trp Gln His Phe Ala Pro His Tyr Asn Phe Glu Asn Asn Thr Ile Ala 
            500                 505                 510         


Leu Ser Leu Met Pro His Thr Phe Lys His Phe Cys Ala Thr Ala Ala 
        515                 520                 525             


Thr Asn Lys Phe Gly Leu Pro His Leu Lys Gln Pro Asp Ala Val Leu 
    530                 535                 540                 


Gly Ile Tyr Glu Leu Pro Gln Leu Val Trp Phe Ala Met Gln Asn Glu 
545                 550                 555                 560 


Lys Asn Pro Lys Lys Ile Glu Ser Phe Ile Glu Arg Thr Ile Asp Thr 
                565                 570                 575     


Tyr Lys Lys Glu Phe Asn Thr Gly Ile Glu Leu Lys Gly Lys Asp Asn 
            580                 585                 590         


Pro Glu Leu Tyr Lys Tyr Asp Tyr Pro Lys Pro Ile Tyr Ala Ile Leu 
        595                 600                 605             


Thr Asn Lys Arg Leu Lys Pro Leu Asp Lys Val Lys Gly Ile Thr Glu 
    610                 615                 620                 


Ala Leu Leu Ala Glu Asn Ser Glu Ile Met Glu Arg Ala Glu Lys Trp 
625                 630                 635                 640 


Leu Gln Ile Ala Lys Glu Lys Ala Ala Ala Ser Lys Ile Ser Lys Gly 
                645                 650                 655     


Lys Thr Asn Lys His Thr Ile Ile Pro Lys Gly Lys Arg Gly Thr Ile 
            660                 665                 670         


Ala Thr Trp Ile Ala Lys Asp Ile Ile Trp Leu Cys Pro Pro Glu Val 
        675                 680                 685             


Arg Met His Ile Gly Gln Ala Phe Ala Asn Ala Leu Gln Glu Asn Leu 
    690                 695                 700                 


Ala Ile Tyr Ser Val Glu Lys Leu Lys Gly Leu Phe Asn Tyr Ser Gly 
705                 710                 715                 720 


Glu Asn Thr Gly Arg Ala Trp Pro Arg Thr Ile Lys Ala Ala His Pro 
                725                 730                 735     


Phe Leu Tyr Glu Lys Thr Gly Ala Arg Asp Asn Leu Phe Asp Phe Tyr 
            740                 745                 750         


Gln Glu Tyr Ile Thr Cys Arg Ala Ala Phe Phe Lys Glu Gln Ala Asp 
        755                 760                 765             


Leu Ala Leu Thr Gly Leu Asn Lys Thr Arg Phe Pro Asp Leu Leu Gly 
    770                 775                 780                 


Ile Ser Ala Asp Ile Lys Ser Leu Ala Asn Tyr Leu Lys Pro Phe Lys 
785                 790                 795                 800 


Thr Asp Gly Gln Glu Thr Leu Thr Val Asn Leu Ala Lys Gly Gly Phe 
                805                 810                 815     


Asn Gly Glu Ile Ala Lys Ile Ala Ala Gly Arg Gln Ala Asn Gln Asn 
            820                 825                 830         


Val Ser Gly Gln Gly Ala Phe Ser Phe Asn Phe Met Leu Ala Gly Leu 
        835                 840                 845             


Gln Pro Gln Thr Gln Glu Phe Tyr Ser Tyr Pro Arg Leu Tyr Lys Arg 
    850                 855                 860                 


Phe Glu Asn Gly Glu Glu Gln Glu Gly Tyr Ile Phe Thr Asp Leu Ala 
865                 870                 875                 880 


Ala Ala Lys Arg Thr Ala Ser Lys Asn Leu Phe Lys Ile Ile Asn Gln 
                885                 890                 895     


Thr Glu Lys Gln Ile Arg Gln Arg Gln Ala Glu Asp Arg Met Leu Phe 
            900                 905                 910         


Leu Met Thr Lys Gln Leu Ser Gly Lys Leu Phe Arg Glu Asp Ile Phe 
        915                 920                 925             


Leu Asp Asn Asn Leu Gly Asp Phe Phe Asn Ala Asn Val Trp Glu Lys 
    930                 935                 940                 


Arg Arg Leu Phe Glu Phe Ser Ile Ala Ala Asn Leu Pro Arg Ile Arg 
945                 950                 955                 960 


Ala Glu Val Arg Leu Lys Asp Ala Gly Ser Phe Thr Lys Phe Leu Ala 
                965                 970                 975     


Asp His Arg Leu Lys Pro Leu Leu Ala Tyr Tyr Asp Leu Pro Ala Val 
            980                 985                 990         


Asp Tyr Met Tyr Gln Leu Pro Ala  Gly Glu Glu Ala Lys  Ala Glu Arg 
        995                 1000                 1005             


Ile Lys  Asn Asn Gln Tyr Tyr  Phe Asp Lys Asp Tyr  Arg Pro Asn 
    1010                 1015                 1020             


Ile Lys  Asp Glu Val Gln Phe  Phe Glu Glu Val Arg  Glu Val Met 
    1025                 1030                 1035             


Phe Ala  Glu Gly Leu Ala Phe  Glu Arg Tyr Val Leu  Glu Trp Ala 
    1040                 1045                 1050             


Asp Gln  Asn Gly Gln Leu Asn  Asn Phe Asn Thr Phe  Tyr Ala Lys 
    1055                 1060                 1065             


Asn Gly  Tyr Ser Asn His Arg  Gln Asp Tyr Leu Leu  Pro Ile Ala 
    1070                 1075                 1080             


Gln Val  Leu Ile Pro Gly Thr  Ile Lys Glu Asp Phe  Lys Thr Pro 
    1085                 1090                 1095             


Glu Val  Leu Ala His Pro Pro  Ala Gln Leu Leu Met  Leu Ser Ile 
    1100                 1105                 1110             


Met Thr  Glu Ile Arg Asn Lys  Thr Ser His Asn Glu  Phe Phe Lys 
    1115                 1120                 1125             


Arg Ile  Trp Lys Gln Leu Phe  Thr Asp Asn Ile Leu  Asp Ile Asp 
    1130                 1135                 1140             


Ala Lys  Arg Asp Glu Phe Ile  Ala Phe Gly Glu Lys  Ser Leu Glu 
    1145                 1150                 1155             


Ser Tyr  Tyr Ser Val Glu Glu  Gln Asn Ser Arg Ser  Val Asn Leu 
    1160                 1165                 1170             


Ser Ala  Glu Ala Lys Val Lys  Arg Ser Leu Asp Thr  Arg Glu Arg 
    1175                 1180                 1185             


Thr Ala  Ile Ser Ile Arg Phe  Phe Lys Asp Phe Cys  Glu Gly Arg 
    1190                 1195                 1200             


Gln Thr  Ala Phe Val Ala Glu  Trp Trp Leu Val Ala  Tyr Arg Tyr 
    1205                 1210                 1215             


Met Ile  Asn Lys Ile Lys Glu  Glu Leu Ile Ile Lys  Ser Val 
    1220                 1225                 1230         


<210>  2202
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2202

Leu Gln Lys Gln Asp Lys Leu Phe Val Asp Arg Lys Lys Asn Ala Ile 
1               5                   10                  15      


Phe Ala Phe Pro Lys Tyr Ile Thr Ile Met Glu Asn Lys Lys Lys Pro 
            20                  25                  30          


Glu Pro Ile Tyr Tyr Glu Leu Thr Asp Lys His Phe Trp Ala Ala Phe 
        35                  40                  45              


Leu Asn Leu Ala Arg His Asn Val Tyr Thr Thr Val Asn His Ile Asn 
    50                  55                  60                  


Lys Leu Leu Glu Ile Ala Glu Leu Lys Asn Asp Glu Asp Val Leu Asn 
65                  70                  75                  80  


Ile Lys Asp Ser Trp Asn Lys Gln Ala Glu Lys Leu Asp Lys Lys Val 
                85                  90                  95      


Arg Leu Arg Asn Leu Leu Met Arg His Phe Pro Phe Leu Glu Ala Ala 
            100                 105                 110         


Ala Tyr Glu Lys Thr Thr Ser Lys Asp Ser Asn Ser Lys Glu Gln Lys 
        115                 120                 125             


Glu Lys Glu Gln Ala Glu Ala Leu Ser Leu Asp Asn Leu Lys Asn Val 
    130                 135                 140                 


Leu Phe Ile Phe Leu Glu Lys Leu Gln Ser Leu Arg Asn Tyr Tyr Ser 
145                 150                 155                 160 


His Tyr Lys Tyr Ser Glu Glu Ala Gln Lys Pro Thr Phe Glu Asn Asp 
                165                 170                 175     


Leu Leu Lys Asn Met Tyr Lys Val Phe Asp Ala Asn Val Arg Leu Val 
            180                 185                 190         


Lys Arg Asp Tyr Met His His Glu Asn Ile Asp Met Gln Arg Asp Phe 
        195                 200                 205             


Thr His Leu Asn Arg Lys Lys Gln Val Gly Arg Thr Lys Asn Ile Ile 
    210                 215                 220                 


Asp Ser Pro Asn Phe His Tyr His Phe Ala Asp Lys Glu Gly Asn Met 
225                 230                 235                 240 


Thr Ile Ala Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Asp Lys Lys 
                245                 250                 255     


Asp Ala Ile Trp Met Gln Lys Lys Leu Lys Gly Phe Lys Asp Gly Arg 
            260                 265                 270         


Asn Leu Arg Glu Gln Met Thr Asn Glu Val Phe Cys Arg Ser Arg Ile 
        275                 280                 285             


Ser Leu Pro Lys Leu Lys Leu Glu Thr Val Gln Thr Arg Glu Trp Met 
    290                 295                 300                 


Gln Leu Asp Met Leu Asn Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr 
305                 310                 315                 320 


Glu Arg Leu Arg Glu Glu Asp Arg Glu Ser Phe Lys Val Pro Phe Asp 
                325                 330                 335     


Ile Phe Ser Asp Asp Tyr Asn Ala Glu Glu Glu Pro Phe Lys Asn Thr 
            340                 345                 350         


Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe 
        355                 360                 365             


Asp Leu Asn Glu Ile Phe Thr Gln Leu Arg Phe Gln Ile Asp Leu Gly 
    370                 375                 380                 


Thr Tyr His Phe Ser Ile Tyr Asn Lys Arg Ile Gly Asp Glu Asp Glu 
385                 390                 395                 400 


Val Arg His Leu Thr His His Leu Tyr Gly Phe Ala His Ile Gln Asp 
                405                 410                 415     


Phe Ala Gln Gln Asn Gln Pro Glu Val Trp Lys Lys Leu Val Lys Asp 
            420                 425                 430         


Leu Asp Tyr Phe Glu Ala Ser Gln Glu Pro Tyr Ile Ser Lys Thr Thr 
        435                 440                 445             


Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Lys Phe Cys Ser 
    450                 455                 460                 


Ala His Asn Asn Leu Phe Pro Ser Leu Gln Thr Asp Lys Thr Cys Asn 
465                 470                 475                 480 


Gly Arg Ser Lys Phe Asn Leu Gly Thr Gln Phe Thr Ala Glu Ala Phe 
                485                 490                 495     


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu 
            500                 505                 510         


Thr Lys Asp Tyr Ser Arg Lys Glu Ser Ala Asp Lys Val Glu Gly Ile 
        515                 520                 525             


Ile Arg Lys Glu Ile Ser Asn Ile Tyr Ala Ile Tyr Asp Ala Phe Ala 
    530                 535                 540                 


Asn Asn Glu Ile Asn Ser Ile Ala Asp Leu Thr Arg Arg Leu Gln Asn 
545                 550                 555                 560 


Thr Asn Ile Leu Gln Gly His Leu Pro Lys Gln Met Ile Ser Ile Leu 
                565                 570                 575     


Glu Gly Arg Gln Lys Asp Met Glu Lys Glu Ala Glu Arg Lys Ile Gly 
            580                 585                 590         


Glu Met Ile Asp Asp Thr Gln Arg Arg Leu Asp Leu Leu Cys Lys Gln 
        595                 600                 605             


Thr Asn Gln Lys Ile Arg Ile Gly Lys Arg Asn Ala Gly Leu Leu Lys 
    610                 615                 620                 


Ser Gly Lys Ile Ala Asp Trp Leu Val Ser Asp Met Met Arg Phe Gln 
625                 630                 635                 640 


Pro Val Gln Lys Asp Thr Asn Asn Ala Pro Ile Asn Asn Ser Lys Ala 
                645                 650                 655     


Asn Ser Thr Glu Tyr Arg Met Leu Gln His Ala Leu Ala Leu Phe Gly 
            660                 665                 670         


Ser Glu Ser Ser Arg Leu Lys Ala Tyr Phe Arg Gln Met Asn Leu Val 
        675                 680                 685             


Gly Asn Ala Asn Pro His Pro Phe Leu Ala Glu Thr Gln Trp Glu His 
    690                 695                 700                 


Gln Thr Asn Ile Leu Ser Phe Tyr Arg Asn Tyr Leu Glu Ala Arg Lys 
705                 710                 715                 720 


Lys Tyr Leu Lys Gly Leu Lys Pro Gln Asn Trp Lys Gln Tyr Gln Tyr 
                725                 730                 735     


Phe Leu Ile Leu Lys Val Gln Lys Thr Asn Arg Asn Thr Leu Val Thr 
            740                 745                 750         


Gly Trp Lys Asn Ser Phe Asn Leu Pro Arg Gly Ile Phe Thr Gln Pro 
        755                 760                 765             


Ile Arg Glu Trp Phe Glu Lys His Asn Asn Ser Lys Arg Ile Tyr Asp 
    770                 775                 780                 


Gln Ile Leu Ser Phe Asp Arg Val Gly Phe Val Ala Lys Ala Ile Pro 
785                 790                 795                 800 


Leu Tyr Phe Ala Glu Glu Tyr Lys Asp Asn Val Gln Pro Phe Tyr Asp 
                805                 810                 815     


Tyr Pro Phe Asn Ile Gly Asn Lys Leu Lys Pro Gln Lys Gly Gln Phe 
            820                 825                 830         


Leu Asp Lys Lys Glu Arg Val Glu Leu Trp Gln Lys Asn Lys Glu Leu 
        835                 840                 845             


Phe Lys Asn Tyr Pro Ser Glu Lys Lys Lys Thr Asp Leu Ala Tyr Leu 
    850                 855                 860                 


Asp Phe Leu Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys 
865                 870                 875                 880 


Asn Gln Asp Ile Val Thr Trp Leu Met Phe Lys Glu Leu Phe Asn Met 
                885                 890                 895     


Ala Thr Val Glu Gly Leu Lys Ile Gly Glu Ile His Leu Arg Asp Ile 
            900                 905                 910         


Asp Thr Asn Thr Ala Lys Ala Glu Ser Asn Asn Ile Leu Asn Arg Ile 
        915                 920                 925             


Met Pro Met Lys Leu Pro Val Lys Thr Tyr Glu Thr Asp Asn Lys Gly 
    930                 935                 940                 


Asn Ile Leu Lys Glu Arg Pro Leu Ala Thr Phe Tyr Ile Glu Glu Thr 
945                 950                 955                 960 


Glu Thr Lys Val Leu Lys Gln Gly Asn Phe Lys Val Leu Ala Lys Asp 
                965                 970                 975     


Arg Arg Leu Asn Gly Leu Leu Ser Phe Ala Glu Thr Thr Asp Ile Asp 
            980                 985                 990         


Leu Glu Lys Asn Pro Ile Thr Lys  Leu Ser Val Asp His  Glu Leu Ile 
        995                 1000                 1005             


Lys Tyr  Gln Thr Thr Arg Ile  Ser Ile Phe Glu Met  Thr Leu Gly 
    1010                 1015                 1020             


Leu Glu  Lys Lys Leu Ile Asp  Lys Tyr Ser Thr Leu  Pro Thr Asp 
    1025                 1030                 1035             


Ser Phe  Arg Asn Met Leu Glu  Arg Trp Leu Gln Cys  Lys Ala Asn 
    1040                 1045                 1050             


Arg Pro  Glu Leu Lys Asn Tyr  Val Asn Ser Leu Ile  Ala Val Arg 
    1055                 1060                 1065             


Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met Tyr Asp  Ala Thr Leu 
    1070                 1075                 1080             


Phe Ala  Glu Val Lys Lys Phe  Thr Leu Phe Pro Ser  Val Asp Thr 
    1085                 1090                 1095             


Lys Lys  Ile Glu Leu Asn Ile  Ala Pro Gln Leu Leu  Glu Ile Val 
    1100                 1105                 1110             


Gly Lys  Ala Ile Lys Glu Ile  Glu Lys Ser Glu Asn  Lys Asn 
    1115                 1120                 1125         


<210>  2203
<211>  1155
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2203

Met Asp Asn Asn Thr Thr Leu Glu Lys Thr Glu Leu Gly Leu Gly Ile 
1               5                   10                  15      


Thr Tyr Asn His Asp Lys Val Glu Asp Lys His Tyr Phe Gly Gly Phe 
            20                  25                  30          


Phe Asn Leu Ala Gln Asn Asn Ile Asp Leu Val Ala Gln Glu Phe Lys 
        35                  40                  45              


Lys Arg Leu Leu Val Gln Gly Lys Asp Ser Ile Asn Ile Phe Ser Asn 
    50                  55                  60                  


Tyr Phe Ser Asp Gln Cys Ser Ile Thr Asn Leu Glu Arg Gly Ile Lys 
65                  70                  75                  80  


Val Leu Ser Glu Tyr Phe Pro Val Ile Phe Tyr Phe Asp Leu Asp Glu 
                85                  90                  95      


Asn Asn Lys Ser Lys Ser Ile Arg Gln His Ile Ile Leu Leu Leu Asp 
            100                 105                 110         


Thr Ile Asn Asn Leu Arg Asn Tyr Tyr Thr His Tyr Tyr His Lys Lys 
        115                 120                 125             


Val Ile Ile Asp Asp Ala Leu Tyr Pro Leu Leu Asp Thr Ile Leu Leu 
    130                 135                 140                 


Lys Val Val Leu Glu Ile Lys Lys Lys Lys Leu Lys Glu Asp Lys Thr 
145                 150                 155                 160 


Lys Gln Leu Leu Lys Lys Gly Leu Glu Lys Glu Met Ala Ile Leu Phe 
                165                 170                 175     


Asn Leu Met Lys Lys Glu Gln Lys Glu Lys Lys Ile Lys Gly Trp Asn 
            180                 185                 190         


Ile Asp Lys Asn Ile Lys Gly Ala Val Leu Asn Arg Ala Phe Ser His 
        195                 200                 205             


Leu Leu Tyr Asn Asp Gly Ile Ser Asp Tyr Arg Lys Ser Lys Ser Asn 
    210                 215                 220                 


Thr Glu Asp Glu Asn Leu Lys Asp Thr Leu Ser Glu Ser Gly Ile Leu 
225                 230                 235                 240 


Phe Leu Leu Ser Phe Phe Leu Asn Lys Lys Glu Gln Glu Gln Leu Lys 
                245                 250                 255     


Ala Asn Ile Lys Gly Tyr Lys Gly Lys Ile Ala Ser Ile Pro Asp Glu 
            260                 265                 270         


Glu Ile Thr Leu Lys Asn Asn Ser Leu Arg Asn Met Ala Thr His Trp 
        275                 280                 285             


Thr Tyr Ser His Leu Thr Tyr Lys Gly Leu Lys His Arg Ile Lys Thr 
    290                 295                 300                 


Asp His Glu Lys Glu Thr Leu Leu Val Asn Met Val Asp Tyr Leu Ser 
305                 310                 315                 320 


Lys Val Pro Asn Glu Ile Tyr Gln Asn Leu Ser Glu Gln Asn Lys Ser 
                325                 330                 335     


Leu Phe Leu Glu Asp Ile Asn Glu Tyr Met Arg Asp Asn Glu Glu Asn 
            340                 345                 350         


Asn Asp Ser Ser Glu Ala Ser Arg Val Ile His Pro Val Ile Arg Lys 
        355                 360                 365             


Arg Tyr Glu Asn Lys Phe Ala Tyr Phe Ala Ile Arg Phe Leu Asp Glu 
    370                 375                 380                 


Phe Ala Glu Phe Pro Thr Leu Arg Phe Met Val Asn Val Gly Asn Tyr 
385                 390                 395                 400 


Ile His Asp Asn Arg Lys Lys Asp Ile Gly Gly Thr Ser Leu Ile Thr 
                405                 410                 415     


Asn Arg Thr Ile Lys Gln Gln Ile Asn Val Phe Gly Asn Leu Thr Glu 
            420                 425                 430         


Ile His Lys Lys Lys Asn Asp Tyr Phe Glu Lys Glu Glu Asn Lys Glu 
        435                 440                 445             


Lys Ile Leu Glu Trp Glu Leu Phe Pro Asn Pro Ser Tyr His Phe Gln 
    450                 455                 460                 


Lys Glu Asn Ile Pro Ile Phe Ile Asp Leu Glu Lys Ser Lys Glu Thr 
465                 470                 475                 480 


Asn Glu Leu Ala Lys Glu Tyr Ala Lys Glu Lys Lys Lys Ile Phe Gly 
                485                 490                 495     


Ser Ser Arg Lys Lys Gln Gln Asn Thr Ala Lys Lys Asn Arg Glu Ala 
            500                 505                 510         


Ile Ile Asn Leu Val Phe Asp Lys Tyr Lys Thr Ser Asp Arg Lys Thr 
        515                 520                 525             


Val Thr Phe Glu Gln Pro Thr Ala Leu Leu Ser Phe Asn Glu Leu Asn 
    530                 535                 540                 


Ala Phe Leu Tyr Ala Phe Leu Val Glu Asn Lys Thr Gly Lys Glu Leu 
545                 550                 555                 560 


Glu Lys Ile Ile Ile Glu Lys Ile Ala Asn Gln Tyr Gln Ile Leu Lys 
                565                 570                 575     


Asn Cys Ser Ser Thr Val Asp Lys Thr Asn Asp Ser Ile Pro Lys Ser 
            580                 585                 590         


Ile Lys Lys Ile Ala His Pro Thr Thr Asp Ser Phe Tyr Ser Glu Gly 
        595                 600                 605             


Lys Lys Ile Asp Ile Glu Lys Leu Glu Arg Asp Ile Lys Ile Glu Ile 
    610                 615                 620                 


Glu Lys Thr Asn Glu Lys Leu Glu Thr Ile Lys Glu Asn Glu Thr Ser 
625                 630                 635                 640 


Ala Lys Asn Tyr Lys Arg Asn Glu Arg Asp Ile Gln Lys Arg Lys Leu 
                645                 650                 655     


Tyr Arg Lys Tyr Val Phe Phe Thr Asn Glu Ile Gly Ile Glu Ala Thr 
            660                 665                 670         


Trp Ile Thr Asn Asp Ile Leu Arg Phe Leu Asp Asn Lys Glu Asn Trp 
        675                 680                 685             


Lys Gly Tyr Gln His Ser Glu Leu Gln Lys Phe Ile Ser Gln Tyr Asp 
    690                 695                 700                 


Asn Tyr Lys Lys Glu Ala Leu Gly Leu Leu Glu Ser Glu Trp Asn Leu 
705                 710                 715                 720 


Glu Ser Glu Ala Phe Phe Gly Gln Lys Leu Lys Arg Ile Phe Gln Ser 
                725                 730                 735     


Asn Phe Thr Phe Glu Thr Phe Tyr Lys Lys Tyr Leu Asp Asn Arg Lys 
            740                 745                 750         


Asp Thr Leu Glu Thr Tyr Leu Ser Ala Ile Glu Asn Leu Lys Thr Met 
        755                 760                 765             


Thr Asp Val Pro Pro Lys Ile Leu Lys Lys Ser Trp Ala Glu Leu Phe 
    770                 775                 780                 


Arg Phe Phe Asp Lys Lys Ile Tyr Leu Leu Ser Thr Ile Glu Thr Lys 
785                 790                 795                 800 


Ile Asn Glu Leu Ile Thr Lys Pro Ile Asn Leu Ser Arg Gly Val Phe 
                805                 810                 815     


Asp Glu Lys Pro Thr Phe Ile Asn Gly Lys Ser Pro Asn Lys Glu Asn 
            820                 825                 830         


Asp Gln His Leu Phe Ala Asn Trp Phe Ile His Ala Lys Glu Gln Thr 
        835                 840                 845             


Ile Phe Gln Asp Phe Tyr Asn Leu Ala Leu Glu Thr Pro Lys Glu Ile 
    850                 855                 860                 


Asn Asn Leu Lys Lys Gln Asn Tyr Lys Leu Glu Arg Ser Ile Asn Asn 
865                 870                 875                 880 


Leu Lys Ile Glu Asp Ile Tyr Ile Lys Gln Met Val Asp Phe Leu Tyr 
                885                 890                 895     


Gln Lys Leu Phe Glu Gln Ser Phe Lys Gly Ser Leu Gln Asp Leu Tyr 
            900                 905                 910         


Thr Ser Lys Glu Lys Arg Glu Val Glu Lys Ser Lys Ala Lys Asn Glu 
        915                 920                 925             


Gln Thr Pro Asp Glu Ser Phe Ile Trp Lys Lys Gln Val Glu Ile Asn 
    930                 935                 940                 


Ala Leu Asn Gly Arg Ile Ile Ala Lys Thr Lys Ile Lys Asp Ile Gly 
945                 950                 955                 960 


Lys Phe Lys Asn Leu Leu Thr Asp Asn Lys Ile Thr His Leu Ile Ser 
                965                 970                 975     


Tyr Asp Asn Arg Ile Trp Asn Phe Ser Leu Asp Asn Asp Gly Asp Thr 
            980                 985                 990         


Thr Lys Lys Leu Tyr Ser Leu Asn  Thr Glu Leu Glu Ser  Tyr Glu Arg 
        995                 1000                 1005             


Ile Arg  Arg Glu Lys Leu Leu  Lys Gln Ile Gln Glu  Phe Glu Gln 
    1010                 1015                 1020             


Phe Leu  Leu Lys Gln Glu Thr  Glu Tyr Ser Ala Glu  Arg Lys His 
    1025                 1030                 1035             


Pro Glu  Lys Phe Glu Lys Asp  Gly Asn Pro Asn Phe  Lys Lys Tyr 
    1040                 1045                 1050             


Ile Ile  Glu Gly Met Leu Asn  Lys Ile Thr Pro Val  Asn Glu Ile 
    1055                 1060                 1065             


Glu Glu  Leu Glu Ile Leu Lys  Ser Lys Glu Asp Val  Phe Lys Ile 
    1070                 1075                 1080             


Asp Phe  Asn Glu Ile Val Lys  Leu Asn Asn Glu Ser  Ile Lys Lys 
    1085                 1090                 1095             


Gly Tyr  Leu Leu Ile Met Ile  Arg Asn Lys Phe Ala  His Asn Gln 
    1100                 1105                 1110             


Leu Ile  Asp Lys Asn Leu Phe  Thr Phe Ser Leu Gln  Leu Tyr Ser 
    1115                 1120                 1125             


Lys Asn  Glu Asn Glu Asn Phe  Ser Glu Tyr Leu Asp  Lys Val Cys 
    1130                 1135                 1140             


Gln Lys  Ile Ile Gln Glu Phe  Ile Glu Lys Leu Lys  
    1145                 1150                 1155 


<210>  2204
<211>  1193
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (348)..(348)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (365)..(365)
<223>  Xaa can be any naturally occurring amino acid

<400>  2204

Met Glu Ser Thr Val Asn Ala Lys Arg Ile Ser Tyr Asp Tyr Lys Asn 
1               5                   10                  15      


Gln Glu Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln Asn 
            20                  25                  30          


Asn Ile Glu Glu Thr Ile Glu Ala Leu Gly Ile Arg Asn Gln Val Phe 
        35                  40                  45              


Lys Lys Glu Asp Ser Asn Lys Lys Asn Lys Ser Arg Pro Ala Glu Ile 
    50                  55                  60                  


Ile Ala Lys Val Phe Gln Ile Asp Leu Lys Lys Arg Lys Thr Lys Asp 
65                  70                  75                  80  


Asp Gly Ser Gly Ile Thr Tyr Ala Gln Trp Glu Ser Asn Val Asn Phe 
                85                  90                  95      


Leu Lys Gln Tyr Leu Pro Ile Val Gln Phe Leu Asn Leu Pro Val Ser 
            100                 105                 110         


His Lys Lys Phe Asp His Leu Pro Lys Ala Lys Lys Glu Lys Ala Lys 
        115                 120                 125             


Arg Asp Tyr Phe Ile Gly Asn Phe Leu Leu Leu Ile Asp Ile Ile Gly 
    130                 135                 140                 


Ser Leu Arg His Tyr Tyr Thr His Tyr His His Lys Gln Ile Ser Ile 
145                 150                 155                 160 


Glu Pro Glu Leu Phe Thr Leu Leu Asp Glu Ile Phe Leu His Thr Cys 
                165                 170                 175     


Leu Val Val Lys Lys Arg Lys Met Lys Ser Glu Lys Thr Arg Glu Leu 
            180                 185                 190         


Leu Lys Arg Glu Leu Glu Arg Glu Val Asp Ile Leu Lys Lys Leu Lys 
        195                 200                 205             


Leu Ala Ala Leu Lys Lys Gln Lys Glu Asp Gly Val Arg Val Ser Leu 
    210                 215                 220                 


Asp Asp Glu His Val Glu Arg Ala Val Leu Asn Glu Ser Phe Asn Tyr 
225                 230                 235                 240 


Leu Leu Ala Lys Arg Asp Asn Val Tyr Lys Val Gln Pro Thr His Cys 
                245                 250                 255     


Ser Arg Gly Glu Asp Gly Thr Pro Phe Ser Arg Ser Gly Leu Val Phe 
            260                 265                 270         


Leu Val Ser Met Phe Leu Thr Lys Lys Gln Gly Glu Asp Phe Arg Ser 
        275                 280                 285             


Arg Ile Lys Gly Phe Lys Glu Lys Ile Val Lys Arg Glu Glu Asn Ala 
    290                 295                 300                 


Ile Ser Pro Thr Asn Asn Ser Leu Arg Phe Met Ala Thr His Trp Val 
305                 310                 315                 320 


Phe Ser Tyr Trp Ser Tyr Lys Gly Phe Lys Ala Lys Leu Asn Thr Thr 
                325                 330                 335     


Phe Ser Lys Glu Val Leu Glu Leu Lys Gly Ile Xaa His Arg Leu Asn 
            340                 345                 350         


Thr Thr Val Ile Ser Lys Glu Ala Leu Leu Ala Gln Xaa Val Asp Glu 
        355                 360                 365             


Leu Ser Lys Val Pro Asp Glu Val Tyr Glu Val Leu Ser Leu Asp Lys 
    370                 375                 380                 


Arg Asn Glu Phe Leu Glu Asp Val Asn Glu Tyr Ile Arg Glu Thr Arg 
385                 390                 395                 400 


Glu Val Glu Thr Leu Asp Lys Ser Ile Val Glu His Ser Val Ile Arg 
                405                 410                 415     


Lys Arg Tyr Glu Ser Lys Phe Gly Tyr Leu Ala Leu Arg Tyr Leu Asp 
            420                 425                 430         


Glu Phe Val Asp Phe Pro Ser Leu Arg Phe Gln Val Arg Leu Gly Asn 
        435                 440                 445             


Tyr Val His Asp Ser Arg Thr Lys Val Ile Glu Gly Thr Lys Leu Val 
    450                 455                 460                 


Thr Glu Arg Gln Ile Lys Glu Pro Ile Asn Val Phe Gly Lys Leu Ser 
465                 470                 475                 480 


Lys Val Lys Glu Leu Lys Thr Gln Phe Phe Leu Ser Ser Asp Asp Glu 
                485                 490                 495     


Glu Asn Ser Met Glu Ile Phe Pro Asn Pro Ser Tyr Cys Phe Val Glu 
            500                 505                 510         


Asn Asn Ile Pro Ile Ile Phe Ser Val Glu Gly Asn Val Lys Ala Asn 
        515                 520                 525             


Ser Ile Tyr Asn Lys Ile Lys Leu Lys Ile Arg Thr Gln Arg Asn Lys 
    530                 535                 540                 


Asp Glu Lys Arg Val Asp Arg Ser Gly Arg Lys Phe Pro Lys Ser Arg 
545                 550                 555                 560 


Ile Phe Ser Ile Val Asn Ser Lys Trp Asp Lys Ser Glu Ser Lys Lys 
                565                 570                 575     


Val Lys Leu Ala Glu Pro Met Ala Leu Leu Ser Phe Asn Glu Leu Pro 
            580                 585                 590         


Ser Leu Leu Tyr Glu Leu Leu His Lys Lys Lys Thr Pro Gln Ala Ile 
        595                 600                 605             


Glu Asp Ala Ile Val Glu Lys Tyr Val Glu Gln Phe Glu Ala Ile Glu 
    610                 615                 620                 


Asn Phe Asp Ser Gln Ser Thr Val Gln Lys Ser Arg Ile Pro Lys Lys 
625                 630                 635                 640 


Met Lys Lys Ser Asp Lys Ile Gly Lys Leu Asp Tyr Glu Lys Leu Val 
                645                 650                 655     


Lys Asp Ile Asp Arg Ser Leu Ala Glu Thr Lys Glu Lys Arg Lys Leu 
            660                 665                 670         


Leu Leu Gln Lys Gln Lys Asp Ala Lys Glu Asn Asn Lys Gln Thr Leu 
        675                 680                 685             


Ser Ser Ser Glu Leu Gly Gln Glu Ala Val Trp Leu Ser Asp Asp Ile 
    690                 695                 700                 


Lys Arg Leu Met Pro Arg Ser Ser Arg Lys Glu Trp Lys Gly Arg His 
705                 710                 715                 720 


His Ser His Leu Gln Tyr Thr Leu Ala Phe Tyr Asp Val Arg Lys Lys 
                725                 730                 735     


Glu Ala Leu Ala Leu Leu Glu Asn Phe Trp Asp Met Asp Lys Asp Pro 
            740                 745                 750         


Tyr Trp Gly Glu Lys Leu Lys Asn Glu Phe Asn Ala Asn Asn Thr Phe 
        755                 760                 765             


Glu Tyr Phe Tyr Phe Ser Tyr Leu Asn Leu Arg Glu Gly Ile Leu Ser 
    770                 775                 780                 


Thr Phe Leu Asp Gln Ile Glu Glu Tyr Lys Asp Gln Pro Gly Asn Leu 
785                 790                 795                 800 


Lys Lys Ala Leu Lys Asp Ile Gly Ile Val Phe Gln Met Arg Lys Tyr 
                805                 810                 815     


Arg Ile Lys Pro Leu Glu Asp Gln Lys Thr Ala Leu Leu Ala Lys Pro 
            820                 825                 830         


Ile Leu Leu Pro Arg Gly Ile Phe Asp Pro Lys Pro Thr Phe Ile Lys 
        835                 840                 845             


Lys Lys Arg Met Asp Glu Phe Pro Asp Glu Phe Ala Glu Trp Tyr Thr 
    850                 855                 860                 


Tyr Ala Asn Ala Pro Glu Arg Gln Phe Gln Arg Phe Tyr Ala Met Glu 
865                 870                 875                 880 


Arg Asp Tyr Gln Glu Leu Trp Lys Thr Glu Lys Asp Thr Asp Pro Asp 
                885                 890                 895     


Phe Lys Gln Asn Lys Lys Gly Ile Ser Glu Glu Gln Gln Ile Ala Leu 
            900                 905                 910         


Phe Lys Met Lys Gln Asp Leu Lys Ile Lys Lys Ile Lys Thr Gln Asp 
        915                 920                 925             


Leu Phe Leu Lys Leu Ile Ala Glu Gln Leu Tyr Leu Asp Val Phe Gly 
    930                 935                 940                 


His Lys Ala Thr Phe Ser Leu Ser Asp Met Tyr Gln Thr Lys Glu Glu 
945                 950                 955                 960 


Arg Arg Glu Ile Glu Arg Leu Ser Ala Lys Gln Ser Asn Arg Ala Gln 
                965                 970                 975     


Gly Asp Lys Ser Asp Asn Ile Val Ser Glu Asn Tyr Ile Trp Asn Lys 
            980                 985                 990         


Thr Val Gly Phe Lys Asp Gln Gln  Leu Glu Glu Pro Cys  Val Lys Leu 
        995                 1000                 1005             


Lys Asp  Ile Gly Lys Ile Arg  Arg Phe Val Asn Asn  Glu Lys Val 
    1010                 1015                 1020             


Gln Lys  Leu Phe Ala Tyr Asn  Leu Asp Arg Ile Trp  Thr Lys Arg 
    1025                 1030                 1035             


Glu Leu  Glu Asp Glu Leu Glu  Met Lys Pro Ser Ser  Tyr Glu Val 
    1040                 1045                 1050             


Ile Arg  Arg Glu Lys Leu Leu  Lys Glu Val Gln Asn  Leu Glu Lys 
    1055                 1060                 1065             


Tyr Ile  Leu Lys Gln Tyr Gly  Phe Asp Asn Glu Asn  His Pro Ser 
    1070                 1075                 1080             


Ile Phe  Glu Arg Asp Gly Asn  Pro Asn Phe Asn Glu  Tyr Val Val 
    1085                 1090                 1095             


Gln Gly  Ile Leu Lys Lys Lys  Asn Leu Val Ser Glu  Asp Glu Cys 
    1100                 1105                 1110             


Asp Trp  Phe Ser Lys Gln Lys  Ile Glu Lys Ile Lys  Leu Asp Thr 
    1115                 1120                 1125             


Leu Arg  Gln Lys Ser Asp Ile  Leu Ile Lys Ala Tyr  Ile Leu Ile 
    1130                 1135                 1140             


Leu Ile  Arg Asn Thr Phe Ala  His Asn Gln Leu Pro  Asp Lys Glu 
    1145                 1150                 1155             


Cys Val  Asp Leu Met Gln Glu  Phe Cys Gln Lys Asp  Pro Gly Ile 
    1160                 1165                 1170             


Ser Tyr  Ser Glu Tyr Phe Leu  Tyr Val Phe Gln Gln  Ile Ala Lys 
    1175                 1180                 1185             


Glu Phe  Thr Asn Ala 
    1190             


<210>  2205
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2205

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Val Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Asn Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Ala Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Asn Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2206
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2206

Met Asn Thr His Gln Glu Glu Leu Gln Ser Trp Ile Thr Arg Lys Arg 
1               5                   10                  15      


Leu Pro Asp Thr Glu Met Lys Lys Tyr Trp Ala Ala Tyr Met Asn Leu 
            20                  25                  30          


Ala Arg Leu Asn Phe Phe Lys Thr Leu Met Phe Ile Ser Asn Ser Ile 
        35                  40                  45              


Gly Asp Leu Lys Pro Ala Lys Asp Asn Asn Gly Lys Gly Asn Thr Glu 
    50                  55                  60                  


Val Asn Met His Asn Met Gly Ile Leu Thr Ala Leu Leu Gly Pro Glu 
65                  70                  75                  80  


Asp Glu Glu Lys Ala Arg Leu Leu Ile Phe Lys His Phe Pro Phe Leu 
                85                  90                  95      


Arg Thr Phe Cys Ile Glu Lys Glu Leu Ser Leu Ser Lys Gln Arg Thr 
            100                 105                 110         


Ile Leu Ile Asp Met Ala Cys Ile Ile Gly Arg Tyr Arg Asn Met Tyr 
        115                 120                 125             


Ser His Ser Ile Phe Leu Ser Asp Asp Asn Glu Lys Val Leu Glu Ser 
    130                 135                 140                 


Glu Lys Arg Cys Ser Glu Tyr Leu Gln Ser Ile Leu Thr Val Ser Thr 
145                 150                 155                 160 


Arg Ile Ile Lys Glu Arg Tyr Arg Ser Asn Lys Asn Asp Ala Gln Arg 
                165                 170                 175     


Gly Met Ile Asp Asp Lys Ser Leu Glu Phe Ile Ser Glu Asn Lys Val 
            180                 185                 190         


Lys Phe Val Tyr Asp Glu Asn Gly Lys Arg Ile Thr Ala Pro Asn Lys 
        195                 200                 205             


Lys Tyr Tyr Leu Ser Thr Ile Asp Lys Asp Asn Thr His Leu Ser Tyr 
    210                 215                 220                 


Phe Gly Lys Leu Met Leu Thr Cys Ile Leu Leu Glu Lys Lys Tyr Ala 
225                 230                 235                 240 


Thr Ala Phe Leu Thr Gln Cys His Phe Leu Asp Ala Phe Asn Asp Ser 
                245                 250                 255     


Glu Ala Ala Pro Lys Leu Ser Glu Arg Arg Leu Met Leu Glu Val Met 
            260                 265                 270         


Thr Ala Leu Arg Ile Arg Leu Ala Glu Lys Lys Leu Ser Asn Glu Lys 
        275                 280                 285             


Ser Glu Val Gln Ile Ser Leu Asp Ile Leu Asn Glu Leu Lys Lys Cys 
    290                 295                 300                 


Pro Phe Glu Leu Tyr Glu Leu Leu Gly Ser Glu Asp Lys Arg Leu Phe 
305                 310                 315                 320 


Thr Ile Val Ala Asp Thr Gly Glu Thr Ile Leu Leu Arg Arg His Glu 
                325                 330                 335     


Asp Arg Phe Pro Gln Leu Ala Leu Ser Trp Ile Asp Ser Ser Lys Ala 
            340                 345                 350         


Phe Asp His Leu Arg Phe Gln Val Asn Ala Gly Lys Leu Arg Tyr Leu 
        355                 360                 365             


Phe Arg Asp Asn Lys His Cys Ile Asp Gly Gln Thr Arg Met Arg Val 
    370                 375                 380                 


Leu Glu Glu Pro Leu Asn Gly Tyr Arg Arg Leu Met Glu Phe Glu Glu 
385                 390                 395                 400 


Glu Trp Ile Gln Lys Gln Ser Gly Glu Ile Arg Ser Leu Trp Pro Gly 
                405                 410                 415     


Leu Asp Ile Leu Asn Lys Asp Glu Thr Pro Arg Asn Asp Ala Ser Val 
            420                 425                 430         


Leu Pro Tyr Ile Ser Asp Tyr Arg Val Arg Tyr Leu Phe Asp Gly Asp 
        435                 440                 445             


Asn Ile Gly Ile Ser Ile Gly Asp Phe Thr Pro Ser Ile Thr Lys Thr 
    450                 455                 460                 


Asp Glu Thr Lys Tyr Arg Val Thr Gly Lys Thr Ala Asp Cys Cys Leu 
465                 470                 475                 480 


Ser Lys Tyr Glu Leu Pro Gly Leu Leu Phe Tyr His Leu Leu Thr Leu 
                485                 490                 495     


Arg Tyr Gly Asp Asn Lys Arg Ser Thr Lys Asn Ala Glu Asp Ile Ile 
            500                 505                 510         


Ile Asp Ala Ile Lys Arg Tyr Lys Arg Leu Phe Ser Asp Val Lys Glu 
        515                 520                 525             


Gly Ile Leu Lys Pro Ile Lys Glu Gly Asn Ala Asn Gln Leu Gly Asn 
    530                 535                 540                 


Arg Ile Trp Asn Ser Tyr Gly Ile Asp Ile Lys Asp Ile Pro Asp Lys 
545                 550                 555                 560 


Ile Ile Asp Tyr Leu Leu Val Arg Glu Cys Asn Glu Asp Glu Lys Phe 
                565                 570                 575     


Thr Ala Trp Lys Asn Gly Leu Ile Ser Glu Met Leu Gln Ser Thr Lys 
            580                 585                 590         


Asn Arg Ile Lys Arg Phe Glu Lys Asp Ser Glu Ala Val Ile Ser Ser 
        595                 600                 605             


Asp Asn Lys Pro Gly Lys Lys Asn His Val Ser Leu Lys Pro Gly Ala 
    610                 615                 620                 


Tyr Ala Ser Phe Ile Ala Asn Asp Ile Val Phe Phe Gln Glu Cys Gly 
625                 630                 635                 640 


Ala Thr Glu Lys Met Thr Gly Leu Asn Phe Lys Val Met Gln Ser Arg 
                645                 650                 655     


Leu Ala Thr Phe Thr Lys Asp Gly Ser Thr Ser Phe Asn Ile Leu Leu 
            660                 665                 670         


Gln Thr Leu Lys Asn Ala His Leu Val Ser Asn Thr Tyr Gly Lys Gly 
        675                 680                 685             


Asp His Pro Phe Leu Tyr Arg Val Ile Lys Gln Gln Pro Ser Asp Ile 
    690                 695                 700                 


Val Gln Phe Tyr Lys Ile Tyr Leu Asn Glu Lys Val Leu Tyr Leu Gln 
705                 710                 715                 720 


Ser Asp Ile Pro Asp Asn Ala Ile Phe Leu His Gly Glu Arg Lys Arg 
                725                 730                 735     


Trp Glu Asn Arg Asn Glu Gln Tyr Tyr Arg Asp Leu Ala Glu Arg Tyr 
            740                 745                 750         


Leu Gln Arg Pro Ile Gln Leu Pro Arg Gln Leu Phe Glu Ser His Ile 
        755                 760                 765             


Arg Gln Leu Leu Leu Ser Asp Cys Ile Lys Gly Glu Arg Gly Asn Asp 
    770                 775                 780                 


Leu Lys Glu Ala Ile Asn Ser Ala Ala Ser Gln Gly Arg Cys Asn Thr 
785                 790                 795                 800 


Thr Tyr Met Ile Met Glu Tyr Phe Ala Asp Tyr Leu Cys Asp Gly Thr 
                805                 810                 815     


Gln Phe Phe Tyr Gly Leu Phe Asp Gly Asp Leu Ser His Glu Tyr Asn 
            820                 825                 830         


Tyr Arg Phe Tyr Ser Leu Ile Ser Asn Asn Ile Glu Asn Ser Lys Lys 
        835                 840                 845             


Leu Val Leu Thr Leu Lys Lys Gly Asn Asn Ser Lys Glu Ser Pro Phe 
    850                 855                 860                 


Ile Ser Ala Leu Glu Arg Gly Ile His Trp Ser Lys Arg Asn Pro Leu 
865                 870                 875                 880 


Met Lys Lys Gly Leu Lys Asn Asp Ser Ser Glu Gly Asp Phe Val His 
                885                 890                 895     


Ala Ala Lys Arg Ala Tyr Lys Glu Met Thr Glu Thr Glu Arg Met Phe 
            900                 905                 910         


Arg Arg Tyr Ala Val Gln Asp Glu Val Leu Phe Leu Ala Ala Lys Ile 
        915                 920                 925             


Thr Ile Arg Arg Ala Leu Gly Leu Ser Glu Gln Tyr Asn Cys Leu Leu 
    930                 935                 940                 


Gly Asp Ile Lys Pro Gln Gly Gly Ser Leu Leu Glu Gln Thr Ile Pro 
945                 950                 955                 960 


Ser Ile Thr Thr Lys His Thr Ile Asn Thr Gly Asn Lys Lys Gln Lys 
                965                 970                 975     


Pro Lys Gln Val Gln Ile Leu Gln Lys Asn Val Lys Leu Lys Asp Phe 
            980                 985                 990         


Gly Lys Val Phe Lys Leu Leu Asn  Asp Arg Arg Ile Phe  Asp Leu Leu 
        995                 1000                 1005             


Phe Asn  Lys Gly Asn Glu Ala  Val Ser Met Thr Asp  Leu Cys Glu 
    1010                 1015                 1020             


Glu Leu  Glu Arg Tyr Asp Arg  His Arg Val Asp Val  Phe Asp Ser 
    1025                 1030                 1035             


Val Leu  Lys Tyr Glu Ser Lys  Ile Thr Lys Gly Tyr  Thr Asn Lys 
    1040                 1045                 1050             


Glu Leu  Met Asn Glu Ser Gly  Gln Ile Asp Phe Lys  Ala Ile Gln 
    1055                 1060                 1065             


Ala Phe  Asp Lys Gln Asn Thr  Thr Ala Asp Lys Glu  Asp Leu Arg 
    1070                 1075                 1080             


Leu Ile  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Gln Tyr Asn 
    1085                 1090                 1095             


Asn Glu  Pro Ile Leu Phe Asp  Lys Asp Ile Pro Glu  Ile Ala Asp 
    1100                 1105                 1110             


Glu Ile  Ser Ile Ile Ala Lys  Asp Ile Glu Glu Asn  Thr Lys 
    1115                 1120                 1125         


<210>  2207
<211>  1242
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2207

Met Glu Gln Asn Arg Lys Glu Gly Ser Leu Arg Thr Gln Glu Asp Ile 
1               5                   10                  15      


Gln Tyr Phe Gly Ser Tyr Phe Asn Met Ala Arg His Asn Leu Tyr Leu 
            20                  25                  30          


Ile Thr Asn His Leu Thr Ser Val Phe Ser His Leu Asn Phe Ser Gln 
        35                  40                  45              


Leu Asp Asp Asp Glu Asp Ile Trp Ser Asp Lys Pro Glu Val Asn Glu 
    50                  55                  60                  


Lys Asn Ile Leu Leu Asn Ile Phe Asp Thr Lys Asn Glu Arg Leu Gln 
65                  70                  75                  80  


Asp Glu Arg Ile Arg Val Phe Arg Tyr Leu Met Arg Arg His His Leu 
                85                  90                  95      


Pro Cys Leu Arg Ile Phe Thr Asn Asp Phe Lys Val Leu Glu Thr Thr 
            100                 105                 110         


Gly Asn Thr Ile Lys Lys Asp Glu Leu Glu Val Asp Phe Asp Ala Val 
        115                 120                 125             


His Lys Phe Leu Asn Ile Ala Phe Lys Glu Ile Asn Leu Phe Arg Asn 
    130                 135                 140                 


Ser Tyr Thr His Tyr Leu Ser Ile Asn Glu Glu Gly Lys Arg Leu Lys 
145                 150                 155                 160 


Lys Lys Lys Lys Ile Ser Ser Lys Leu Val Pro Val Leu Asn Ser Leu 
                165                 170                 175     


Phe Ser Tyr Ala Pro Glu Tyr Ser Phe Leu Arg His Asn Ile Asp Lys 
            180                 185                 190         


Ala Asn Lys Asp Val Lys Ile Tyr Lys Glu Glu Val Lys Glu Tyr Tyr 
        195                 200                 205             


Asp Asn Ile Lys Ser Lys Tyr Lys Leu Phe Glu Asn Asp Ser Asn Glu 
    210                 215                 220                 


Leu Thr Asp Gln Gly Met Tyr Phe Phe Ile Thr Leu Phe Leu Glu Arg 
225                 230                 235                 240 


Ala His Gly Ile Lys Phe Leu Lys Arg Phe Arg Gly Phe Lys Asn Glu 
                245                 250                 255     


Thr Thr Pro Pro Phe Lys Ala Thr Ile Gln Ala Phe Thr Thr Tyr Thr 
            260                 265                 270         


Leu Lys Ile Pro Asp Val Arg Leu Asp Asn Asp Ile Pro Glu Gln Thr 
        275                 280                 285             


Met Ile Met Glu Val Leu Asn Glu Leu Asn Lys Cys Pro Glu Glu Leu 
    290                 295                 300                 


Phe Lys Phe Leu Lys Lys Glu Asp Lys Asp Arg Phe Gln Pro Val Ile 
305                 310                 315                 320 


Ser Asp Glu Ser Leu Thr Asn Ile Ile Asn Ser Ser Asn Tyr Glu Glu 
                325                 330                 335     


Ile Ser Asp Glu Asp Ile Asp Arg Leu Ile Lys Glu Asn Ser Val Leu 
            340                 345                 350         


Lys Arg Arg Glu Asp Arg Phe Pro Tyr Phe Ala Leu Gln Tyr Leu Glu 
        355                 360                 365             


Ile Met Ser Lys Leu Lys Asn Ile Arg Phe Gln Ile Tyr Leu Gly Lys 
    370                 375                 380                 


Leu Val Leu Lys Thr Tyr Asp Lys Glu Asn Pro Asn Ile Glu Arg Arg 
385                 390                 395                 400 


Val Ile Thr Asp Ile His Ala Phe Gly Lys Leu Ser Asp Phe Val Gly 
                405                 410                 415     


Lys Glu Ala Glu Val Leu Asp Thr Phe Asn Ser Gln Leu Lys Asp Tyr 
            420                 425                 430         


Gly Tyr Ser Val Ala Trp Asp Gln Tyr Lys Pro Ser Tyr Ala Ile Glu 
        435                 440                 445             


Met Asn Arg Ile Gly Phe Tyr Leu Phe Asn Asp Gln Gly Asp Lys Val 
    450                 455                 460                 


Glu Asn Lys Ile Leu Pro Ser Leu Cys Lys Asn Lys Asn Leu Glu Arg 
465                 470                 475                 480 


Lys Val Glu Ile Lys Val Asn Lys Ile Gln Pro Thr Gly Phe Ile Ser 
                485                 490                 495     


Thr His Met Leu Pro Lys Phe Leu Ile Ser Tyr Leu Met Gly Asp Val 
            500                 505                 510         


Asn Glu Lys Asn Gly Glu Lys Thr Ile Thr His Phe Leu Glu Lys Val 
        515                 520                 525             


Asn Val Ser Ile Leu Asp Gln Asn Ile Ile Asn Gln Ile Lys Ser Glu 
    530                 535                 540                 


Ile Gln Asn Leu Asp Pro Ile Glu Phe Thr Lys Arg Cys Pro Lys Leu 
545                 550                 555                 560 


Ser Ala Ile Lys Asn Val Lys Lys Leu Arg Val Ala Gly Ala Ile Asp 
                565                 570                 575     


Lys Lys Ile Val Glu Tyr Gln Tyr Ile Asn Asp Thr Asp Ile Ala Lys 
            580                 585                 590         


Leu Val Gln Lys Thr Gly Leu Ala Tyr Asp Thr Met Val Thr Tyr Ser 
        595                 600                 605             


Lys Asp Lys Phe Lys Glu Lys Thr Asn His Leu Asn Leu Ser Lys Lys 
    610                 615                 620                 


Glu Leu Glu Thr Phe Ala His Ile Lys Tyr Lys Tyr Tyr Leu Ser Glu 
625                 630                 635                 640 


Arg Arg Lys Ala Leu Asp Ser Val Leu Lys Ala Tyr Phe Pro Glu Ile 
                645                 650                 655     


Gly Ser Gln Asp Ile Pro Lys Glu Leu Tyr Asn Tyr Leu Leu Asn Ile 
            660                 665                 670         


Asn Glu Gln Asp Asn Lys Lys Leu Glu His Arg Arg Ile Lys Asp Glu 
        675                 680                 685             


Val Thr Lys Thr Lys Lys Leu Ile Lys Asp Val Asn Arg Ser Leu Lys 
    690                 695                 700                 


Phe Glu Asp Lys Ile Leu Leu Gly Asp Leu Ala Thr Lys Ile Ala Arg 
705                 710                 715                 720 


Asp Ile Ile Asn Met Ile Ile Asp Lys Asp Leu Lys Val Ser Met Thr 
                725                 730                 735     


Asn Pro Phe Ala Asn Arg Leu Gln Asn Leu Ile Ala Tyr Phe Ser Thr 
            740                 745                 750         


Asn Lys Glu Ala Ile Val Ala Leu Cys Glu Ser Tyr Lys Val Phe Glu 
        755                 760                 765             


His Asn Lys Gly His Phe Phe Leu Thr Arg Glu Leu Ile Leu Asn Ser 
    770                 775                 780                 


Thr Gly Val Ile Asp Phe Tyr Ile Arg Tyr Phe Glu Ala Lys Ile Glu 
785                 790                 795                 800 


Lys Ile Lys Glu Val Leu Leu Val Arg Gly Lys Glu Gly Gly Tyr Glu 
                805                 810                 815     


Ile Asn Thr Glu Leu Ile Pro Tyr Ser Tyr Thr Gln Tyr Leu Pro Lys 
            820                 825                 830         


Glu Val Lys Glu Glu Asn Lys Asn Thr Cys Lys Asn Leu Phe Glu Gln 
        835                 840                 845             


Trp Leu Tyr Tyr Lys Gln Lys Ser Pro Val Asn Leu Pro Val Thr Leu 
    850                 855                 860                 


Leu Asp Glu Asp Leu Thr Ser Ala Leu Lys Ser Lys Leu Lys Leu Lys 
865                 870                 875                 880 


Pro Asp Leu Lys Asp Gly Phe Ser Lys Leu Ile Gln Leu Tyr Leu Lys 
                885                 890                 895     


Asp Asp Ala Gln Glu Phe Tyr Ser Phe Asp Arg Val Tyr Arg Asn Asn 
            900                 905                 910         


Asp Asn Glu His Val Ile Lys Tyr Ser Asn Glu Gly Ser Ser Lys Glu 
        915                 920                 925             


Met Gln Ile Lys Tyr Gly Lys Val Ala Val Glu Ser Glu Lys Ile Ile 
    930                 935                 940                 


Arg His Val Leu Leu Lys Asp Arg Ile Leu Arg Val Ile Cys Glu Asp 
945                 950                 955                 960 


Leu Leu Lys Ser Asp Lys Asn Thr Ser Ser Thr Lys Ser Phe Leu Leu 
                965                 970                 975     


Lys Asp Ile Ser Pro Trp Ser Glu Thr Asn Ile Leu Asn Lys Pro Asn 
            980                 985                 990         


Glu Phe Ser Tyr Asn Leu Arg Lys  Asn Ile Asp Gly Ser  Gly Thr Glu 
        995                 1000                 1005             


Tyr Cys  Thr Ile Val Ala Lys  Asp Ser Thr Glu Gln  Ile Arg Gln 
    1010                 1015                 1020             


Ile Asn  Glu Trp Asn Asp Leu  Ser Lys Glu Ile Lys  Ser Lys Phe 
    1025                 1030                 1035             


Leu Lys  Leu Asn Ala Glu Gln  Lys Ile Asp Phe Leu  Thr Thr Gln 
    1040                 1045                 1050             


Asp Glu  Lys Thr Lys Leu Val  Leu Leu Gly Gln Gln  Asn Tyr Gln 
    1055                 1060                 1065             


Trp Lys  Phe Ser Asp Phe Gly  Arg Phe Arg Arg Phe  Met Lys Asp 
    1070                 1075                 1080             


Lys Arg  Ile Asn Glu Met Val  Lys Tyr Phe Glu Pro  Lys Gln Ile 
    1085                 1090                 1095             


Pro Phe  Asp Leu Leu Glu Phe  Gln Ile Leu Gln Tyr  Asn Ile Tyr 
    1100                 1105                 1110             


Arg Glu  Lys Met Phe Asp Lys  Ile Phe Glu Leu Glu  Arg Val Met 
    1115                 1120                 1125             


Ser Glu  Arg Tyr Phe Glu Asp  Ile Lys Ser Lys His  Leu Glu Asn 
    1130                 1135                 1140             


Phe Lys  Tyr Asn Glu Val Gly  Phe Gln Thr Tyr Leu  Asn Val Leu 
    1145                 1150                 1155             


Ser Glu  Lys Ile Ala Ser Gly  Tyr Asp Ile Ala Ile  Leu Lys Trp 
    1160                 1165                 1170             


Gly Arg  Asn Lys Phe Ser His  Thr Glu Ile Val Tyr  Tyr Asn Phe 
    1175                 1180                 1185             


Ile Ser  Lys Ile Ala Val Gln  Asp Ile Glu Glu Phe  Glu Leu Lys 
    1190                 1195                 1200             


Lys His  Leu Glu Gly Tyr Lys  Glu Asn Val Ser Phe  Asn Ile Ala 
    1205                 1210                 1215             


Arg Asn  Ile Tyr Arg Val Phe  Ser Arg Glu Val Asp  Lys Thr Ile 
    1220                 1225                 1230             


Asn Leu  Ile Asn Asn Ser Phe  Lys Ile 
    1235                 1240         


<210>  2208
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2208

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Thr 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2209
<211>  1179
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2209

Met Ser Ser Lys Asn Glu Ser Tyr Asn Lys Gln Lys Thr Phe Asn His 
1               5                   10                  15      


Tyr Lys Gln Glu Asp Lys Tyr Phe Phe Gly Gly Phe Leu Asn Asn Ala 
            20                  25                  30          


Asp Asp Asn Leu Arg Gln Val Gly Lys Glu Phe Lys Thr Arg Ile Asn 
        35                  40                  45              


Phe Asn His Asn Asn Asn Glu Leu Ala Ser Val Phe Lys Asp Tyr Phe 
    50                  55                  60                  


Asn Lys Glu Lys Ser Val Ala Lys Arg Glu His Ala Leu Asn Leu Leu 
65                  70                  75                  80  


Ser Asn Tyr Phe Pro Val Leu Glu Arg Ile Gln Lys His Thr Asn His 
                85                  90                  95      


Asn Phe Glu Gln Thr Arg Glu Ile Phe Glu Leu Leu Leu Asp Thr Ile 
            100                 105                 110         


Lys Lys Leu Arg Asp Tyr Tyr Thr His His Tyr His Lys Pro Ile Thr 
        115                 120                 125             


Ile Asn Pro Lys Ile Tyr Asp Phe Leu Asp Asp Thr Leu Leu Asp Val 
    130                 135                 140                 


Leu Ile Thr Ile Lys Lys Lys Lys Val Lys Asn Asp Thr Ser Arg Glu 
145                 150                 155                 160 


Leu Leu Lys Glu Lys Leu Arg Pro Glu Leu Thr Gln Leu Lys Asn Gln 
                165                 170                 175     


Lys Arg Glu Glu Leu Ile Lys Lys Gly Lys Lys Leu Leu Glu Glu Asn 
            180                 185                 190         


Leu Glu Asn Ala Val Phe Asn His Cys Leu Arg Pro Phe Leu Glu Glu 
        195                 200                 205             


Asn Lys Thr Asp Asp Lys Gln Asn Lys Thr Val Ser Leu Arg Lys Tyr 
    210                 215                 220                 


Arg Lys Ser Lys Pro Asn Glu Glu Thr Ser Ile Thr Leu Thr Gln Ser 
225                 230                 235                 240 


Gly Leu Val Phe Leu Met Ser Phe Phe Leu His Arg Lys Glu Phe Gln 
                245                 250                 255     


Val Phe Thr Ser Gly Leu Glu Gly Phe Lys Ala Lys Val Asn Thr Ile 
            260                 265                 270         


Lys Glu Glu Glu Ile Ser Leu Asn Lys Asn Asn Ile Val Tyr Met Ile 
        275                 280                 285             


Thr His Trp Ser Tyr Ser Tyr Tyr Asn Phe Lys Gly Leu Lys His Arg 
    290                 295                 300                 


Ile Lys Thr Asp Gln Gly Val Ser Thr Leu Glu Gln Asn Asn Thr Thr 
305                 310                 315                 320 


His Ser Leu Thr Asn Thr Asn Thr Lys Glu Ala Leu Leu Thr Gln Ile 
                325                 330                 335     


Val Asp Tyr Leu Ser Lys Val Pro Asn Glu Ile Tyr Glu Thr Leu Ser 
            340                 345                 350         


Glu Lys Gln Gln Lys Glu Phe Glu Glu Asp Ile Asn Glu Tyr Met Arg 
        355                 360                 365             


Glu Asn Pro Glu Asn Glu Asp Ser Thr Phe Ser Ser Ile Val Ser His 
    370                 375                 380                 


Lys Val Ile Arg Lys Arg Tyr Glu Asn Lys Phe Asn Tyr Phe Ala Met 
385                 390                 395                 400 


Arg Phe Leu Asp Glu Tyr Ala Glu Leu Pro Thr Leu Arg Phe Met Val 
                405                 410                 415     


Asn Phe Gly Asp Tyr Ile Lys Asp Arg Gln Lys Lys Ile Leu Glu Ser 
            420                 425                 430         


Ile Gln Phe Asp Ser Glu Arg Ile Ile Lys Lys Glu Ile His Leu Phe 
        435                 440                 445             


Glu Lys Leu Gly Leu Val Thr Glu Tyr Lys Lys Asn Val Tyr Leu Lys 
    450                 455                 460                 


Glu Thr Ser Asn Ile Asp Leu Ser Arg Phe Pro Leu Phe Pro Ser Pro 
465                 470                 475                 480 


Ser Tyr Val Met Ala Asn Asn Asn Ile Pro Phe Tyr Ile Asp Ser Lys 
                485                 490                 495     


Ser Asn Asn Leu Asp Glu Tyr Leu Asn Gln Lys Lys Lys Ala Gln Ser 
            500                 505                 510         


Gln Asn Arg Lys Arg Asn Leu Thr Phe Glu Lys Tyr Asn Lys Glu Gln 
        515                 520                 525             


Ser Lys Asp Ala Ile Ile Ala Met Leu Gln Lys Glu Ile Gly Val Lys 
    530                 535                 540                 


Asp Leu Gln Gln Arg Ser Thr Ile Gly Leu Leu Ser Cys Asn Glu Leu 
545                 550                 555                 560 


Pro Ser Met Leu Tyr Glu Val Ile Val Lys Asp Ile Lys Gly Ala Glu 
                565                 570                 575     


Leu Glu Asn Lys Ile Ala Gln Lys Ile Arg Glu Gln Tyr Gln Ser Ile 
            580                 585                 590         


Arg Asp Phe Thr Leu Asp Ser Pro Gln Lys Asp Asn Ile Pro Ala Thr 
        595                 600                 605             


Leu Thr Lys Thr Ile Ser Thr Asp Thr Ser Val Thr Phe Glu Asn Gln 
    610                 615                 620                 


Pro Ile Asp Ile Pro Arg Leu Lys Asn Ala Ile Gln Lys Glu Leu Ala 
625                 630                 635                 640 


Leu Thr Gln Glu Lys Leu Leu Asn Val Lys Gln His Glu Ile Glu Val 
                645                 650                 655     


Asp Asn Tyr Asn Arg Asn Lys Asn Thr Tyr Lys Phe Lys Asn Gln Pro 
            660                 665                 670         


Lys Asp Lys Val Asp Asp Asn Lys Leu Gln Arg Lys Tyr Val Phe Tyr 
        675                 680                 685             


His Asn Glu Ile Gly Gln Glu Ala Asn Trp Leu Ala Ser Asp Leu Ile 
    690                 695                 700                 


His Phe Met Lys Asn Lys Ser Leu Trp Lys Gly Tyr Met His Asn Glu 
705                 710                 715                 720 


Leu Gln Ser Leu Leu Ala Phe Phe Glu Asp Lys Lys Asn Asp Cys Ile 
                725                 730                 735     


Ala Leu Leu Glu Thr Val Phe Asn Leu Lys Glu Asp Cys Ile Leu Thr 
            740                 745                 750         


Lys Asp Leu Lys Asn Leu Phe Leu Lys His Gly Asn Phe Ile Asp Phe 
        755                 760                 765             


Tyr Lys Glu Tyr Leu Lys Leu Lys Glu Asp Phe Leu Ser Thr Glu Ser 
    770                 775                 780                 


Thr Phe Leu Glu Asn Gly Phe Ile Gly Leu Pro Pro Lys Ile Leu Lys 
785                 790                 795                 800 


Lys Glu Leu Ser Lys Arg Leu Asn Tyr Ile Phe Ile Val Phe Gln Lys 
                805                 810                 815     


Arg Gln Phe Ile Ile Lys Glu Leu Glu Glu Lys Lys Asn Asn Leu Tyr 
            820                 825                 830         


Ala Asp Ala Ile Asn Leu Ser Arg Gly Ile Phe Asp Glu Lys Pro Thr 
        835                 840                 845             


Met Ile Pro Phe Lys Lys Pro Asn Pro Asp Glu Phe Ala Ser Trp Phe 
    850                 855                 860                 


Val Ala Ser Tyr Gln Tyr Asn Asn Tyr Gln Ser Phe Tyr Glu Leu Thr 
865                 870                 875                 880 


Pro Asp Lys Ile Glu Asn Asp Lys Lys Lys Lys Tyr Lys Asn Leu Arg 
                885                 890                 895     


Ala Ile Asn Lys Val Lys Ile Gln Asp Tyr Tyr Leu Lys Leu Met Val 
            900                 905                 910         


Asp Thr Leu Tyr Gln Asp Leu Phe Asn Gln Pro Leu Asp Lys Ser Leu 
        915                 920                 925             


Ser Asp Phe Tyr Val Ser Lys Ala Glu Arg Glu Lys Ile Lys Asn Asp 
    930                 935                 940                 


Ala Lys Ala Tyr Gln Lys Arg Asn Asp Ser Phe Leu Trp Asn Lys Val 
945                 950                 955                 960 


Ile His Leu Ser Leu Gln Asn Asn Arg Ile Thr Ala Asn Pro Lys Leu 
                965                 970                 975     


Lys Asp Ile Gly Lys Tyr Lys Arg Ala Leu Gln Asp Glu Lys Ile Ala 
            980                 985                 990         


Thr Leu Leu Thr Tyr Asp Asp Arg  Thr Trp Thr Tyr Ala  Leu Glu Lys 
        995                 1000                 1005             


Pro Glu  Lys Glu Lys Glu Asn  Asp Tyr Lys Glu Leu  His Tyr Thr 
    1010                 1015                 1020             


Ala Leu  Asn Met Glu Leu Gln  Glu Tyr Glu Lys Val  Arg Ser Lys 
    1025                 1030                 1035             


Lys Leu  Leu Lys Gln Val Gln  Gln Leu Glu Lys Gln  Ile Leu Glu 
    1040                 1045                 1050             


Glu Tyr  Thr Asp Phe Ser Ser  Thr Gln Ile His Pro  Ala Asp Phe 
    1055                 1060                 1065             


Glu Arg  Glu Gly Asn Pro Asn  Phe Lys Lys Tyr Leu  Ala His Ser 
    1070                 1075                 1080             


Ile Leu  Ala Asn Glu Asp Glu  Ile Asp Lys Leu Pro  Glu Lys Val 
    1085                 1090                 1095             


Glu Ala  Met Met Lys Leu Asp  Glu Thr Ile Thr Asn  Pro Ile Ile 
    1100                 1105                 1110             


Lys Lys  Ala Ile Val Leu Ile  Ile Ile Arg Asn Lys  Met Ala His 
    1115                 1120                 1125             


Asn Gln  Tyr Pro Pro Lys Phe  Ile Tyr Asp Leu Ala  Thr Arg Phe 
    1130                 1135                 1140             


Val Pro  Lys Lys Glu Glu Glu  Tyr Phe Ala Cys Tyr  Phe Asn Arg 
    1145                 1150                 1155             


Val Phe  Glu Thr Ile Thr Thr  Glu Leu Trp Glu Asn  Lys Lys Lys 
    1160                 1165                 1170             


Lys Asp  Lys Thr Arg Val 
    1175                 


<210>  2210
<211>  1214
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2210

Leu Ile Leu Ser Phe Ile Ile Phe Asn Phe Ile Val Ile Ile Asn Gln 
1               5                   10                  15      


His Thr Leu Asn Thr Tyr Thr Arg Lys Tyr Met Lys Asp Lys Ser Phe 
            20                  25                  30          


Ser Thr Ile Ser Ser Ala Ile Asn Glu Thr Ile Thr Thr Asp Asn Ile 
        35                  40                  45              


Lys Tyr Pro Glu Gln Leu Asn Leu Ile Leu Ser Lys Arg Leu Arg Pro 
    50                  55                  60                  


Lys Asn Glu Leu Gln Pro Leu Trp Ala Ala Tyr Phe Asn Met Ala Arg 
65                  70                  75                  80  


Tyr Asn Met Tyr Thr Thr Leu Val His Ile Ala Thr Ala Thr Gly Leu 
                85                  90                  95      


Ser Asp Glu Asp Asn Met Glu Asn Arg Met Asp Lys Met Arg Ile Leu 
            100                 105                 110         


Asn Glu Pro Val Glu Pro Glu Ile Glu His Arg Leu Arg Lys Leu Leu 
        115                 120                 125             


Cys Arg His Phe Pro Phe Ala Val Trp Met Ile Cys Ser Pro Ile Arg 
    130                 135                 140                 


Lys Lys Asp Ser Lys Glu Asp Ser Ala Asp Glu Asp Tyr Arg Val Ile 
145                 150                 155                 160 


Ser Val Lys Glu Leu Arg Asp Cys Leu Lys Thr Val Ser Tyr Thr Leu 
                165                 170                 175     


Asn Tyr Phe Arg Asn Tyr Tyr Ser His Thr Arg His Val Glu Thr Arg 
            180                 185                 190         


Ser Glu Asp Ile Ile Ala Ala Ser Arg Asn Ser Glu Lys Gln Thr Gly 
        195                 200                 205             


Ile Phe Leu Asn Lys Val Cys Thr Val Ala Thr Arg Arg Val Lys Ser 
    210                 215                 220                 


Arg Phe Ser Asp Lys Ser Asn Lys Gly Gln Ala Gly Met Ile Asp Asp 
225                 230                 235                 240 


Gln Ser Met Lys Phe Ile Thr Glu Gly Lys Val Lys Phe Arg Asn Asn 
                245                 250                 255     


Asn Gly Ile Lys Glu Thr Ile Tyr Asn Pro Asp His Phe Leu Tyr Pro 
            260                 265                 270         


Leu Phe Leu Asn Arg Ser Ser Ala Leu Arg Asp Gly Thr Asn Pro Glu 
        275                 280                 285             


Arg Leu Ser Thr Val Gly Lys Ile Gln Leu Ile Cys Leu Leu Leu Asp 
    290                 295                 300                 


Lys Lys Tyr Ile Thr Glu Phe Leu Asp Gln Ser Gly Phe Leu Ser Ala 
305                 310                 315                 320 


Phe Asn Asn Asp Ala Pro Ala Pro Lys Leu Ser Glu Arg Arg Leu Ile 
                325                 330                 335     


Leu Glu Val Leu Ser Asp Leu Arg Ile Arg Leu Pro Gln Arg Lys Ile 
            340                 345                 350         


Asp Ala Thr Cys Asn Asp Ile Gln Val Ala Leu Asp Met Leu Asn Glu 
        355                 360                 365             


Leu Lys Lys Cys Pro Lys Glu Leu Phe Glu Leu Leu Glu Ala Lys Asp 
    370                 375                 380                 


Lys Ala Thr Phe Ser Ile Leu Ser Ser Thr Gly Glu His Ile Leu Leu 
385                 390                 395                 400 


Arg Arg Ser Ser Asp Arg Phe Thr Gln Leu Ala Leu Gln Trp Phe Asp 
                405                 410                 415     


Val Asn Lys Ala Phe Ser Arg Ile Arg Phe His Met Asn Ala Gly Ile 
            420                 425                 430         


Phe Arg Tyr Leu Phe Asn Asp Ser Lys Thr Cys Ile Asp Gly Lys Thr 
        435                 440                 445             


Arg Leu Arg Val Leu Gln Glu Pro Leu Asn Cys Phe Gly Arg Ile Gln 
    450                 455                 460                 


Glu Val Glu Asp Ser Arg Glu Ser Asn Arg Asp Gly Asn Asp Gly Pro 
465                 470                 475                 480 


Trp Arg Gly Phe Glu Ile Lys Gly Phe Asp Glu Ala Ala Arg Asn Asp 
                485                 490                 495     


Val Asn Cys Leu Pro Tyr Ile Asn Asp Ser Arg Thr Arg Tyr Leu Ile 
            500                 505                 510         


Thr Glu Asp Asn Ile Gly Ile Arg Phe Ser Gly Asp Asp Glu Ala Cys 
        515                 520                 525             


Gly Asn Tyr Phe Pro Arg Ile Asp Glu Lys Asn Gly Lys Tyr Lys Val 
    530                 535                 540                 


Thr Cys Leu Pro Ala Gln Cys Met Ile Ser Ile Tyr Glu Leu Gln Ala 
545                 550                 555                 560 


Met Leu Phe Leu His Leu Leu Asn Pro Gly Asn Asp Gly Gly Ile Ala 
                565                 570                 575     


Pro Val Glu Lys Ile Ile Ile Asp Lys Val Glu Ser Tyr Arg Arg Phe 
            580                 585                 590         


Phe Ser Asp Ile Lys Asn Gly Leu Leu Thr Pro Ser Gly Leu Thr Glu 
        595                 600                 605             


Ser Ser Leu Asn Asp Lys Leu Thr Ser Thr Tyr Gly Ile Ser Leu Ser 
    610                 615                 620                 


Asp Ile Pro Asp Lys Met Lys Asp Tyr Leu Leu Lys Lys Asn Asn Lys 
625                 630                 635                 640 


Gly Arg Gly Phe Asn Ala Tyr Arg Asp Arg Leu Ile Glu Thr Leu Lys 
                645                 650                 655     


Glu Glu Thr Glu Tyr Arg Ile Lys Arg Leu Glu Glu Asn Leu Asn Ala 
            660                 665                 670         


Thr Asn Ser Asp Thr Asn Lys Pro Gly Lys Pro Gly Tyr Val Gln Ile 
        675                 680                 685             


Lys Pro Gly Ser Leu Ala Ser Phe Ile Ser Lys Asp Ile Val Phe Phe 
    690                 695                 700                 


Gln Glu Cys Asn Ala Asp Gln Lys Met Thr Gly Leu Asn Phe Ser Val 
705                 710                 715                 720 


Met Gln Gly Leu Ile Ala Thr Phe Gly Ser Gln Glu Gly Ala Thr Thr 
                725                 730                 735     


Asp Asp Leu Arg Met Ala Phe Arg Lys Ser Gly Leu Ile Ala Ala Asn 
            740                 745                 750         


Gly Ser Cys Gly Thr His Pro Phe Leu Ala Ile Ala Phe Asn Ala Gly 
        755                 760                 765             


Ala Lys Asn Thr Val Asp Leu Tyr Lys Glu Tyr Leu Asn Ala Arg Lys 
    770                 775                 780                 


Ser Tyr Leu Ser Gly Ile Ile Pro Asp Asn Ala Pro Phe Leu His Ala 
785                 790                 795                 800 


Asp Arg Ile Arg Trp Ala Val Asn Asp Asp Ala Tyr Tyr Lys Asp Tyr 
                805                 810                 815     


Ala Glu Arg Cys Leu Gln Arg Pro Val Ile Leu Pro Arg Arg Leu Phe 
            820                 825                 830         


Glu Ala Ser Ile Arg Glu Asn Leu Leu Ala Leu Asn Gly Glu Asn Ala 
        835                 840                 845             


Asn Ala Leu Lys Lys Val Ile Ile Gly Ala Gly Gly His Cys Asn Ser 
    850                 855                 860                 


Ala Phe Met Ile Asp Ser Tyr Phe Tyr Tyr Val Lys Asn Asp Ser Pro 
865                 870                 875                 880 


Gln Val Phe His Gly Ala Cys Glu Gly Asp Met Leu His Thr Tyr Gly 
                885                 890                 895     


His Arg Phe Phe Gln Val Val Arg Arg Asn Leu Lys Asn Ala Glu Ala 
            900                 905                 910         


Ile Leu Ser Lys Leu Lys Lys Asp Ser Asn Thr His Asn Thr Tyr Ile 
        915                 920                 925             


Gly Ala Leu Ser Asp Ala Ile Cys Trp Ala Lys Glu Asn Pro Ile Lys 
    930                 935                 940                 


Pro Thr Phe Ser Val Gly Arg Ser Arg Leu Asn Asn His Ser Glu Asn 
945                 950                 955                 960 


Glu Ile Ala Ala Met Ile Lys Arg Ala Phe Asn Glu Tyr Met Ala Thr 
                965                 970                 975     


Glu Lys Thr Leu Arg Arg Tyr Val Ile Gln Asp Glu Leu Leu Phe Leu 
            980                 985                 990         


Ala Ala Met Lys Thr Ile Lys Ser  Lys Leu Gly Val Pro  Asp Ser Glu 
        995                 1000                 1005             


Trp Lys  Leu Gly Ser Ile Gly  Ser Lys Ser Gly Ser  Ile Leu Asp 
    1010                 1015                 1020             


Lys Glu  Leu Pro Leu Ile Gln  Thr Pro Ala Lys Phe  Ser Asn Ile 
    1025                 1030                 1035             


Lys Arg  Arg Pro Asn Lys Thr  Ile Thr Lys Asp Leu  Val Glu Leu 
    1040                 1045                 1050             


Val Ile  Glu Gln His Asn Val  Ser Ile Lys Asp Tyr  Gly Glu Ile 
    1055                 1060                 1065             


Tyr Arg  Ile Leu Ala Asp Glu  Arg Leu Tyr Gly Leu  Leu Lys Tyr 
    1070                 1075                 1080             


His Lys  Asn Glu Thr Val Leu  Ala Ser Asp Leu Lys  Asn Glu Ile 
    1085                 1090                 1095             


Glu Lys  Tyr Asp Glu Lys Arg  Val Lys Val Phe Glu  Asp Ile Met 
    1100                 1105                 1110             


Asn Tyr  Glu Lys Lys Ile Thr  Asn Gly Val Thr Asp  Arg Gln Leu 
    1115                 1120                 1125             


Cys Glu  Ser Met Asp His Ala  Lys Asp Ile Asp Phe  Lys Val Met 
    1130                 1135                 1140             


Gln Thr  Phe Asp Thr Met Asn  Asp Asn Leu Thr Lys  Met Glu Leu 
    1145                 1150                 1155             


Arg Ser  Ile Arg Asn Ala Phe  Cys His Asn Ser Tyr  Pro Asp Val 
    1160                 1165                 1170             


Asn Ala  Phe Asp Asn Ser Ser  Gly Thr Thr Lys Arg  Ile Arg Ile 
    1175                 1180                 1185             


His Asn  Ala Tyr Ile Pro Gly  Thr Ala Glu Lys Ile  Ser Glu Ile 
    1190                 1195                 1200             


Val Asn  Asp Ile Ser Ser Lys  Thr Lys Ala Lys 
    1205                 1210                 


<210>  2211
<211>  909
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2211

Met Lys Met Phe Tyr Lys Ser Val Leu Thr Ala Phe Phe Thr Ala Val 
1               5                   10                  15      


Asp Ser Leu Arg Asn Lys Tyr Thr His Tyr Ser His Lys Asp Leu Asn 
            20                  25                  30          


Ile Arg Glu Ile Lys Ile Glu Cys Thr Leu Gly Gly Lys Asp Tyr Cys 
        35                  40                  45              


Ile Gly Leu Leu Asn Ala Leu Asp Cys Ile Tyr Asp Ser Ala Val Asn 
    50                  55                  60                  


Leu Leu Lys Leu Arg Phe Met Ala Gly Glu Asp Glu Val Ala His Leu 
65                  70                  75                  80  


Arg Arg Cys Lys Ala Val Asn Lys Lys Val Val Val Arg Thr Glu Lys 
                85                  90                  95      


Asp Gly Phe Tyr Tyr Arg Leu Ser Asp Asn Gly Gly Val Thr Glu Lys 
            100                 105                 110         


Gly Val Ile Phe Ile Ala Ser Met Phe Leu Asn Arg Lys Tyr Gly Phe 
        115                 120                 125             


Leu Phe Leu Lys Gln Leu Glu Gly Phe Lys Arg Ser Asp Glu Lys Arg 
    130                 135                 140                 


Tyr Arg Leu Thr Leu Glu Ala Phe Leu Ala Phe Ser Asn Ile Lys Pro 
145                 150                 155                 160 


Val Asp Arg Leu Lys Ser Asp Lys Leu Asp Arg Ala Ser Leu Gly Leu 
                165                 170                 175     


Asp Met Leu Asn Glu Leu Thr Lys Ile Pro Lys Glu Leu Ser Glu Thr 
            180                 185                 190         


Leu Ser Val Asp Cys Leu Tyr Lys Tyr Leu Ala Ser Asp Gly Glu Asp 
        195                 200                 205             


Asp Leu Arg Ser Arg Ile Arg Tyr Gln Asp Arg Phe Val Pro Leu Ala 
    210                 215                 220                 


Leu Glu Phe Ile Ser Gln Ser Asp Glu Phe Lys Asp Phe Arg Phe Tyr 
225                 230                 235                 240 


Thr Tyr Val Gly Asn Tyr Val Tyr Lys Gly Tyr Ile Lys Arg Leu Ile 
                245                 250                 255     


Asp Gly Thr Asp Lys Glu Arg Tyr Leu Ser Asp Arg Leu Cys Gly Phe 
            260                 265                 270         


Tyr Lys Ser Val Asn Asp Ala Ser Ser Asp Ala Ile Ala Gln Lys Tyr 
        275                 280                 285             


Gly Val Glu Ile Lys Asp Ser Asn Glu Pro Asp Tyr Met Leu Pro Asp 
    290                 295                 300                 


Ser Phe Arg Pro His Val Leu Arg Ala Thr Pro His Phe Val Ile Asn 
305                 310                 315                 320 


Thr Asn Asn Ile Gly Ile Lys Ile Cys Gly Asn Asp Cys Leu Pro Ile 
                325                 330                 335     


Val Asn Gly Lys Gly Val Glu Ser Pro Glu Pro Asp Tyr Trp Leu Ser 
            340                 345                 350         


Ile Tyr Glu Leu Pro Ala Met Leu Phe Tyr Ala Tyr Leu Arg Glu Lys 
        355                 360                 365             


Asn Gly Lys Arg Phe Lys Asp Tyr Lys Ser Ile Arg Glu Leu Ile Glu 
    370                 375                 380                 


Gly Val Glu Lys Lys Ala Asp Glu Lys Asn Asp Arg Asp Lys Gly Ala 
385                 390                 395                 400 


Leu Met Ala Arg His Ile Asp Lys Glu Ile Ile Trp Thr Gln Thr Lys 
                405                 410                 415     


Leu Asp Glu Val Lys Arg Leu Glu Glu Lys Lys Val Ala Ala Tyr Gly 
            420                 425                 430         


Lys Lys Gly Arg Val Val Leu Lys Ala Gly Arg Met Ala Asp Leu Leu 
        435                 440                 445             


Ala His Asp Met Val Arg Leu Gln Pro Ala Thr Lys Gly Ser Asp Lys 
    450                 455                 460                 


Ile Thr Gly Ala Asn Phe Gln Ala Leu Gln Val Ser Leu Ala Tyr Phe 
465                 470                 475                 480 


Lys Arg Asp Ile Leu Ala Asp Val Phe Ser Arg Ala Met Leu Thr Thr 
                485                 490                 495     


Gly Asn His Arg His Pro Phe Leu Tyr Arg Ile Asp Val Ser His Cys 
            500                 505                 510         


Ser Ser Leu Arg Asp Phe Tyr Val Ala Tyr Leu Gly Glu Arg Arg Lys 
        515                 520                 525             


Tyr Phe Glu Asp Val Ala Lys Lys Ile Ala Lys Asn Lys Leu Asn Thr 
    530                 535                 540                 


Pro Cys His Ile Leu Arg Arg Leu Gln Arg Glu Gly Ser Gly Glu Glu 
545                 550                 555                 560 


Ala Gly Lys Asp Val Lys Pro Lys Phe Leu Pro Arg Gly Ile Phe Thr 
                565                 570                 575     


Asp Ser Ile Lys Asn Cys Leu Glu Gln Ser Lys Leu Asn Ile Tyr Ile 
            580                 585                 590         


Arg Asn Ala Arg Asn Asp Val Lys Pro Ala Ile Asn Ala Ala Tyr Leu 
        595                 600                 605             


Ile Leu Met Tyr Tyr Lys Glu Ile Glu Lys Gly Glu Phe Gln Gly Phe 
    610                 615                 620                 


Tyr Gly Glu Lys Arg Arg Tyr Asp Ile Leu Glu Glu Gly Lys Pro Leu 
625                 630                 635                 640 


Asp Leu Ala Glu Arg Lys Lys Ala Leu Ala Ser Ile Lys Pro Ala Lys 
                645                 650                 655     


Ile Asp Val Ser Glu Ala Asn Met Pro Met Ser Lys Glu Glu His Leu 
            660                 665                 670         


Met Arg Lys Arg Tyr His Ala Val Cys Asn Asn Glu Ser Ala Ile Arg 
        675                 680                 685             


Met Tyr Gln Val Gln Asp Ile Leu Leu Leu Leu Met Ala Lys Asp Ile 
    690                 695                 700                 


Phe Lys Lys Ala Leu Ser Glu Gly Val Met Ser Lys Lys Ile Gly Leu 
705                 710                 715                 720 


Glu Asn Leu Asn Gly Ile Phe Asp Ala Pro Val Asn Phe Val Lys Asn 
                725                 730                 735     


Phe Asp Asn Ile Lys Leu Thr Ala Thr Gly Ile Lys Ile Lys Asp Tyr 
            740                 745                 750         


Gly Lys Val Cys Arg Leu Gly Thr Asp Phe Lys Phe Asn Ser Leu Ile 
        755                 760                 765             


Lys Ala Phe His Lys Val Tyr Ser Lys Ser Val Glu Met Asp Tyr Ser 
    770                 775                 780                 


Asp Tyr Leu Lys Glu Glu Glu Glu Phe Glu Lys Tyr Arg Leu Asn Met 
785                 790                 795                 800 


Val Lys Leu Cys Arg Glu Val Glu Arg Gly Ile Thr Glu Asp Leu His 
                805                 810                 815     


Leu Ser Leu Asp Gly Lys Ser His Leu Ser Phe Asn Asp Asp Val Ile 
            820                 825                 830         


Lys Pro Tyr Asn Asp Lys Tyr Asn Val Phe Asn Gly Gly Asp Leu Thr 
        835                 840                 845             


Phe Phe Ile Asn Ala Arg Asn Met Phe Met His Gly Asp Tyr Lys Tyr 
    850                 855                 860                 


Glu Cys Val Lys Tyr Val Val Ser Glu His Phe Lys Gly Ser Leu Asn 
865                 870                 875                 880 


Asp Val Ser Phe Ala Lys Glu Thr Tyr Gly His Phe Cys Asn Leu Leu 
                885                 890                 895     


Glu Ser Met Arg Lys Lys Thr Gly Leu Arg Ile Asp Ile 
            900                 905                 


<210>  2212
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2212

Met Asn Thr His Gln Glu Glu Leu Gln Ser Trp Ile Thr Arg Lys Arg 
1               5                   10                  15      


Leu Pro Asp Thr Glu Met Lys Lys Tyr Trp Ala Ala Tyr Met Asn Leu 
            20                  25                  30          


Ala Arg Leu Asn Phe Phe Lys Thr Leu Met Phe Ile Ser Asn Ser Ile 
        35                  40                  45              


Gly Asp Leu Lys Pro Ala Lys Asp Asn Asn Gly Lys Gly Asn Thr Glu 
    50                  55                  60                  


Val Asn Met His Asn Met Gly Ile Leu Thr Ala Leu Leu Gly Pro Glu 
65                  70                  75                  80  


Asp Glu Glu Lys Ala Arg Leu Leu Ile Phe Lys His Phe Pro Phe Leu 
                85                  90                  95      


Arg Thr Phe Cys Ile Glu Lys Glu Leu Ser Leu Ser Lys Gln Arg Thr 
            100                 105                 110         


Ile Leu Ile Asp Met Ala Cys Ile Ile Gly Arg Tyr Arg Asn Met Tyr 
        115                 120                 125             


Ser His Ser Ile Phe Ile Ser Asp Asp Asn Glu Lys Val Leu Glu Ser 
    130                 135                 140                 


Glu Lys Arg Cys Ser Glu Tyr Leu Gln Ser Ile Leu Thr Val Ser Thr 
145                 150                 155                 160 


Arg Ile Ile Lys Glu Arg Tyr Arg Ser Asn Lys Asn Asp Ala Gln Arg 
                165                 170                 175     


Gly Met Ile Asp Asp Lys Ser Leu Lys Phe Ile Ser Glu Asn Lys Val 
            180                 185                 190         


Lys Phe Val Tyr Asp Glu Asn Gly Lys Arg Ile Thr Ala Pro Asn Lys 
        195                 200                 205             


Lys Tyr Tyr Leu Ser Thr Ile Asp Lys Asp Asn Thr His Leu Ser Tyr 
    210                 215                 220                 


Phe Gly Lys Leu Met Leu Thr Cys Ile Leu Leu Glu Lys Lys Tyr Ala 
225                 230                 235                 240 


Thr Asp Phe Leu Thr Gln Cys His Phe Leu Asp Ala Phe Asn Asp Ser 
                245                 250                 255     


Glu Val Ala Pro Lys Leu Ser Glu Arg Arg Leu Met Leu Glu Val Met 
            260                 265                 270         


Thr Ala Leu Arg Ile Arg Leu Ala Glu Lys Lys Leu Ser Asn Glu Lys 
        275                 280                 285             


Ser Glu Val Gln Ile Ser Leu Asp Ile Leu Asn Glu Leu Lys Lys Cys 
    290                 295                 300                 


Pro Phe Glu Leu Tyr Glu Leu Leu Gly Ser Glu Asp Lys Arg Leu Phe 
305                 310                 315                 320 


Thr Ile Val Ala Asp Thr Gly Glu Thr Ile Leu Leu Arg Arg His Glu 
                325                 330                 335     


Asp Arg Phe Pro Gln Leu Ala Leu Ser Trp Ile Asp Ser Ser Lys Ala 
            340                 345                 350         


Phe Asp His Leu Arg Phe Gln Val Asn Ala Gly Lys Leu Arg Tyr Leu 
        355                 360                 365             


Phe Arg Asp Asn Lys His Cys Ile Asp Gly Gln Thr Arg Met Arg Val 
    370                 375                 380                 


Leu Glu Glu Pro Leu Asn Gly Tyr Arg Arg Leu Met Glu Phe Glu Glu 
385                 390                 395                 400 


Glu Arg Ile Gln Lys Gln Ser Gly Glu Ile Arg Ser Leu Trp Pro Gly 
                405                 410                 415     


Leu Asp Ile Leu Asn Lys Asp Glu Thr Pro Arg Asn Asp Ala Ser Val 
            420                 425                 430         


Leu Pro Tyr Ile Ser Asp Tyr Arg Val Arg Tyr Leu Phe Asp Gly Asp 
        435                 440                 445             


Asn Ile Gly Ile Ser Ile Gly Asp Phe Thr Pro Ser Ile Thr Lys Thr 
    450                 455                 460                 


Asp Glu Thr Lys Tyr Arg Val Thr Gly Lys Thr Ala Asp Cys Cys Leu 
465                 470                 475                 480 


Ser Lys Tyr Glu Leu Pro Gly Leu Leu Phe Tyr His Leu Leu Thr Leu 
                485                 490                 495     


Arg His Gly Asp Asn Lys Arg Ser Thr Lys Asn Ala Glu Asp Ile Ile 
            500                 505                 510         


Ile Asp Ala Ile Lys Arg Tyr Lys Arg Leu Phe Ser Asp Val Lys Glu 
        515                 520                 525             


Gly Ile Leu Lys Pro Ile Lys Glu Glu Asn Ala Asn Gln Leu Gly Asn 
    530                 535                 540                 


Arg Ile Trp Asn Ser Tyr Gly Ile Asn Ile Lys Asp Ile Pro Asp Lys 
545                 550                 555                 560 


Ile Ile Asp Tyr Leu Leu Val Arg Glu Cys Asn Glu Asp Glu Lys Phe 
                565                 570                 575     


Thr Ala Trp Lys Asn Gly Phe Ile Ser Glu Met Leu Gln Ser Thr Lys 
            580                 585                 590         


Asn Arg Ile Lys Arg Phe Glu Lys Asp Ser Glu Ala Val Ile Ser Ser 
        595                 600                 605             


Asp Asn Lys Pro Gly Lys Lys Asn His Val Ser Leu Lys Pro Gly Ala 
    610                 615                 620                 


Tyr Ala Ser Phe Ile Ala Asn Asp Ile Val Phe Phe Gln Glu Cys Gly 
625                 630                 635                 640 


Ala Thr Glu Lys Met Thr Gly Leu Asn Phe Lys Val Met Gln Ser Arg 
                645                 650                 655     


Leu Ala Thr Phe Thr Lys Asp Gly Ser Thr Ser Phe Asn Ile Leu Leu 
            660                 665                 670         


Gln Thr Leu Lys Asn Ala His Leu Val Ser Thr Thr Tyr Gly Lys Gly 
        675                 680                 685             


Asp His Pro Phe Leu Tyr Arg Val Ile Lys Gln Gln Pro Ser Asp Ile 
    690                 695                 700                 


Val Gln Phe Tyr Lys Ile Tyr Leu Asn Glu Lys Val Leu Tyr Leu Gln 
705                 710                 715                 720 


Ser Asp Ile Pro Asp Asn Ala Ile Phe Leu His Gly Glu Arg Lys Arg 
                725                 730                 735     


Trp Glu Asn Arg Asn Glu Gln Tyr Tyr Arg Asp Leu Ala Glu Arg Tyr 
            740                 745                 750         


Leu Gln Arg Pro Ile Gln Leu Pro Arg Gln Leu Phe Glu Ser His Ile 
        755                 760                 765             


Arg Gln Leu Leu Leu Ser Asp Cys Ile Lys Gly Glu Arg Gly Asn Asp 
    770                 775                 780                 


Leu Lys Glu Ala Ile Asn Ser Ala Ala Ser Gln Gly Arg Cys Asn Thr 
785                 790                 795                 800 


Thr Tyr Met Ile Met Glu Tyr Phe Ala Asp Tyr Leu Cys Asp Gly Thr 
                805                 810                 815     


Gln Phe Phe Tyr Gly Leu Phe Asp Gly Asp Leu Ser His Glu Tyr Asn 
            820                 825                 830         


Tyr Arg Phe Tyr Ser Leu Ile Ser Asn Asn Ile Glu Asn Ser Lys Lys 
        835                 840                 845             


Leu Val Leu Thr Leu Lys Lys Gly Asn Asn Ser Lys Glu Ser Pro Phe 
    850                 855                 860                 


Ile Ser Ala Leu Glu Arg Gly Ile His Trp Ser Lys Met Asn Pro Leu 
865                 870                 875                 880 


Met Lys Lys Gly Leu Lys Asn Asp Ser Ser Glu Gly Asp Phe Val His 
                885                 890                 895     


Ala Ala Lys Arg Ala Tyr Lys Glu Met Thr Glu Thr Glu Arg Met Phe 
            900                 905                 910         


Arg Arg Tyr Ala Val Gln Asp Glu Val Leu Phe Leu Ala Ala Lys Ile 
        915                 920                 925             


Thr Ile Arg Arg Val Leu Gly Leu Ser Glu Gln Tyr Asn Cys Leu Leu 
    930                 935                 940                 


Gly Asp Ile Lys Pro Gln Gly Gly Ser Leu Leu Glu Gln Thr Ile Pro 
945                 950                 955                 960 


Ser Ile Thr Thr Lys His Thr Ile Asn Thr Gly Asn Lys Lys Gln Lys 
                965                 970                 975     


Pro Lys Gln Val Gln Ile Leu Gln Lys Asn Val Lys Leu Lys Asp Phe 
            980                 985                 990         


Gly Lys Val Phe Lys Leu Leu Asn  Asp Arg Arg Ile Phe  Asp Leu Leu 
        995                 1000                 1005             


Phe Asn  Lys Gly Asn Glu Ala  Val Ser Met Thr Asp  Leu Cys Glu 
    1010                 1015                 1020             


Glu Leu  Glu Arg Tyr Asp Arg  His Arg Val Asp Val  Phe Asp Ser 
    1025                 1030                 1035             


Val Leu  Lys Tyr Glu Ser Lys  Ile Thr Lys Gly Tyr  Thr Asn Lys 
    1040                 1045                 1050             


Glu Leu  Met Asn Glu Ser Gly  Gln Ile Asp Phe Lys  Ala Ile Gln 
    1055                 1060                 1065             


Ala Phe  Asp Lys Gln Asn Thr  Thr Ala Asp Lys Glu  Asp Leu Arg 
    1070                 1075                 1080             


Leu Ile  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Gln Tyr Asn 
    1085                 1090                 1095             


Asn Glu  Pro Ile Leu Phe Asp  Lys Asp Ile Pro Glu  Ile Ala Asp 
    1100                 1105                 1110             


Glu Ile  Ser Ile Ile Ala Lys  Asp Ile Glu Glu Asn  Thr Lys 
    1115                 1120                 1125         


<210>  2213
<211>  1146
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2213

Met Glu Ser Ile Ile Gly Leu Gly Leu Ser Phe Asn Pro Tyr Lys Thr 
1               5                   10                  15      


Ala Asp Lys His Tyr Phe Gly Ser Phe Leu Asn Leu Ala Asp Asn Asn 
            20                  25                  30          


Leu Lys Ala Val Phe Ala Glu Phe Lys Glu Arg Ile Ser Asp Lys Ser 
        35                  40                  45              


Lys Asp Glu Asp Ile Ser Asn Leu Ile Glu Lys His Phe Ile Asp Asn 
    50                  55                  60                  


Met Ser Ile Val Asp Tyr Glu Lys Asn Ile Ser Ile Leu Asn Gly Tyr 
65                  70                  75                  80  


Leu Pro Ile Ile Asp Phe Leu Asp Asp Glu Leu Glu Asn Asn Leu Asn 
                85                  90                  95      


Thr Arg Val Lys Asn Phe Lys Lys Ser Phe Ile Ile Leu Ala Glu Ala 
            100                 105                 110         


Leu Glu Thr Leu Arg Asn Tyr Tyr Thr His Phe Tyr His Asp Pro Ile 
        115                 120                 125             


Thr Phe Gly Asp Asn Lys Glu Pro Leu Leu Glu Leu Leu Asp Glu Val 
    130                 135                 140                 


Leu Leu Lys Thr Ile Leu Asp Val Lys Lys Lys Tyr Leu Lys Thr Asp 
145                 150                 155                 160 


Lys Thr Lys Glu Ile Leu Lys Asp Ser Leu Arg Glu Glu Met Asp Leu 
                165                 170                 175     


Leu Val Ile Arg Lys Thr Asp Glu Leu Arg Glu Lys Lys Lys Thr Asn 
            180                 185                 190         


Pro Lys Phe Lys Phe Ser Thr Asp Pro Thr Gln Ile Arg Asn Ser Ile 
        195                 200                 205             


Phe Asn Asp Ala Phe Gln Gly Leu Leu Tyr Glu Asp Lys Glu Asn Asn 
    210                 215                 220                 


Gly Lys Thr Gln Val Ser Tyr Arg Ala Lys Thr Lys Leu Asn Pro Lys 
225                 230                 235                 240 


Asp Ile His Lys Gln Glu Glu Arg Asp Phe Glu Ile Pro Leu Ser Thr 
                245                 250                 255     


Ser Gly Ile Val Phe Leu Met Ser Leu Phe Leu Ser Lys Lys Glu Ile 
            260                 265                 270         


Glu Asp Phe Lys Ser Asn Ile Lys Gly Phe Lys Gly Lys Val Val Lys 
        275                 280                 285             


Asp Glu Asn His Asn Ser Leu Lys Tyr Met Ala Thr His Arg Val Tyr 
    290                 295                 300                 


Ser Ile Leu Ala Phe Lys Gly Leu Lys Tyr Arg Ile Lys Thr Asp Thr 
305                 310                 315                 320 


Phe Ser Lys Val Thr Leu Met Met Gln Met Ile Asp Glu Leu Ser Lys 
                325                 330                 335     


Val Pro Asp Cys Val Tyr Gln Asn Leu Ser Glu Thr Lys Gln Lys Asp 
            340                 345                 350         


Phe Ile Glu Asp Trp Asn Glu Tyr Leu Lys Asp Asn Glu Glu Asn Thr 
        355                 360                 365             


Glu Asn Leu Glu Asn Ser Arg Val Val His Pro Leu Ile Arg Lys Arg 
    370                 375                 380                 


Tyr Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe 
385                 390                 395                 400 


Ala Asn Phe Lys Thr Leu Lys Phe Gln Val Phe Met Gly Tyr Tyr Ile 
                405                 410                 415     


His Asp Gln Arg Thr Lys Thr Ile Gly Thr Thr Asn Ile Thr Thr Glu 
            420                 425                 430         


Arg Thr Val Lys Glu Lys Ile Asn Val Phe Gly Lys Leu Ser Lys Met 
        435                 440                 445             


Asp Asn Leu Lys Lys His Phe Phe Ser Gln Leu Ser Asp Glu Glu Asn 
    450                 455                 460                 


Thr Asp Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Phe Leu Thr Gln 
465                 470                 475                 480 


Ala Asp Asn Ser Pro Ala Asn Asn Ile Pro Ile Tyr Leu Glu Leu Lys 
                485                 490                 495     


Asn Gln Gln Ile Ile Lys Glu Lys Asp Asp Ile Lys Ala Glu Val Asn 
            500                 505                 510         


Asn Ser Gln Asn Arg Asn Pro Asn Lys Pro Ser Lys Arg Asp Leu Leu 
        515                 520                 525             


Asn Lys Ile Ser Asn Thr Asn Glu Asp Phe Tyr Gln Gly Asp Pro Thr 
    530                 535                 540                 


Ala Ile Leu Ser Leu Asn Glu Ile Pro Ala Leu Leu His Leu Phe Leu 
545                 550                 555                 560 


Val Gln Pro Asp Asn Lys Thr Gly Gln Gln Ile Glu Asn Ile Ile Arg 
                565                 570                 575     


Ile Lys Ile Glu Lys Gln Phe Asn Ser Ile Lys Asn Pro Ser Lys Asp 
            580                 585                 590         


Asp Lys Gly Val Pro Lys Ser Leu Phe Ala Asp Thr Asn Val Arg Val 
        595                 600                 605             


Asn Ala Ile Lys Leu Lys Lys Asp Leu Gly Glu Glu Leu Asp Met Leu 
    610                 615                 620                 


Asn Lys Lys Gln Ile Val Phe Lys Glu Asn Gln Lys Ala Ser Ser Asn 
625                 630                 635                 640 


Tyr Asp Glu Leu Leu Lys Lys His Gln Phe Thr Pro Lys Asn Lys Arg 
                645                 650                 655     


Pro Ala Leu Arg Lys Tyr Val Phe Tyr Asn Ser Glu Lys Gly Glu Glu 
            660                 665                 670         


Ala Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Lys Gly Phe 
        675                 680                 685             


Lys Thr Lys Trp Lys Gly Tyr Gln His Ser Glu Leu Gln Arg Lys Leu 
    690                 695                 700                 


Ala Phe Tyr Asp Arg His Thr Lys Gln Asp Ile Lys Glu Leu Leu Ser 
705                 710                 715                 720 


Gly Cys Glu Phe Asp His Phe Leu Leu Asp Ile Asn Ala Cys Phe Lys 
                725                 730                 735     


Glu Asp Asp Phe Glu Asp Phe Phe Ser Lys Tyr Leu Lys Asn Arg Ile 
            740                 745                 750         


Glu Thr Leu Asn Ile Ile Leu Lys Gln Leu His Asp Phe Lys Asn Glu 
        755                 760                 765             


Pro Thr Pro Leu Lys Gly Val Phe Lys Asn Cys Leu Lys Phe Leu Lys 
    770                 775                 780                 


Gln Lys Asn Tyr Val Thr Glu Asn Pro Glu Ile Ile Lys Lys Arg Ile 
785                 790                 795                 800 


Leu Ala Lys Pro Ala Phe Leu Pro Arg Gly Ile Phe Asp Glu Arg Pro 
                805                 810                 815     


Thr Met Lys Lys Gly Lys Asn Pro Leu Ile Asp Arg Asp Glu Phe Ala 
            820                 825                 830         


Lys Trp Phe Val Glu Tyr Leu Glu Asn Lys Asp Tyr Gln Lys Phe Tyr 
        835                 840                 845             


Asn Ser Glu Glu Tyr Arg Ile Arg Asp Ala Asp Phe Lys Lys Asn Ala 
    850                 855                 860                 


Val Ile Lys Lys Gln Lys Leu Lys Asp Phe Tyr Thr Leu Gln Met Val 
865                 870                 875                 880 


Asn Tyr Leu Leu Lys Glu Val Phe Gly Lys Asp Glu Met Asn Leu Gln 
                885                 890                 895     


Leu Ser Glu Leu Phe Gln Thr Arg Gln Glu Arg Leu Lys Leu Gln Gly 
            900                 905                 910         


Ile Ala Lys Lys Gln Met Asn Lys Glu Thr Gly Asp Ser Ser Glu Asn 
        915                 920                 925             


Thr Arg Asn Gln Thr Tyr Ile Trp Asn Lys Asp Val Pro Val Ser Phe 
    930                 935                 940                 


Phe Asn Gly Lys Val Thr Ile Asp Lys Val Lys Leu Lys Asn Ile Gly 
945                 950                 955                 960 


Lys Tyr Lys Arg Tyr Glu Arg Asp Glu Arg Val Lys Thr Phe Ile Gly 
                965                 970                 975     


Tyr Glu Val Asp Glu Lys Trp Met Met Tyr Leu Pro His Asn Trp Lys 
            980                 985                 990         


Asp Arg Tyr Ser Val Lys Pro Ile  Asn Val Ile Asp Leu  Gln Ile Gln 
        995                 1000                 1005             


Glu Tyr  Glu Glu Ile Arg Ser  His Glu Leu Leu Lys  Glu Ile Gln 
    1010                 1015                 1020             


Asn Leu  Glu Gln Tyr Ile Tyr  Asp His Thr Thr Asp  Lys Asn Thr 
    1025                 1030                 1035             


Leu Leu  Gln Asp Gly Asn Pro  Asn Phe Lys Met Tyr  Val Leu Asn 
    1040                 1045                 1050             


Gly Leu  Leu Thr Gly Ile Lys  Gln Val Asn Ile Ala  Asp Phe Ile 
    1055                 1060                 1065             


Val Leu  Lys Gln Asn Thr Asn  Phe Asp Lys Ile Asp  Phe Thr Gly 
    1070                 1075                 1080             


Ile Ala  Ser Cys Ser Glu Leu  Glu Lys Lys Thr Ile  Ile Leu Ile 
    1085                 1090                 1095             


Ala Ile  Arg Asn Lys Phe Ala  His Asn Gln Leu Pro  Asn Lys Thr 
    1100                 1105                 1110             


Ile Tyr  Asp Leu Ala Asn Glu  Phe Leu Lys Lys Glu  Lys Arg Glu 
    1115                 1120                 1125             


Thr Tyr  Ala Asn Tyr Tyr Leu  Lys Val Leu Lys Lys  Met Ile Ser 
    1130                 1135                 1140             


Asp Leu  Ala 
    1145     


<210>  2214
<211>  1220
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2214

Met Ser Thr Arg Tyr Thr Asn Gln Lys Lys Val Glu Glu Asn Ile Asn 
1               5                   10                  15      


Tyr Val Phe Ser Asn Lys Gly Ile Phe Ala Ala Val Ala Glu Lys Thr 
            20                  25                  30          


Leu Thr Asn Tyr Lys Ser Lys Phe Asn Glu Gly Gln Thr Ile Gln Pro 
        35                  40                  45              


Asn Leu His Tyr Phe Ala Val Gly His Thr Phe Lys Asn Ile Asp Thr 
    50                  55                  60                  


Lys Arg Ile Phe Asp Tyr Gln Leu Ser Glu Asp Glu Met Asp Ile Leu 
65                  70                  75                  80  


Pro Thr Lys Tyr Phe Ser Leu Gln Gln Asn Lys Phe Ser Phe Pro Ile 
                85                  90                  95      


Asp Gly Gln Thr Lys Thr Asp Lys Leu Tyr Leu Leu Leu Asp Asn Ile 
            100                 105                 110         


Arg Asn Ile Asn Ala His Phe Ile His Asp Phe Asn Phe Leu Lys Val 
        115                 120                 125             


Asp Asn Ile Asp Glu Asn Ile Ile Cys Phe Leu Ile Asp Ser Phe Glu 
    130                 135                 140                 


Leu Ala Leu Ile Lys Gly Val Phe Ala Lys Lys Tyr Gly Asn Lys Lys 
145                 150                 155                 160 


His Glu Leu Gly Leu Asp Phe Leu Ser Asn Asp Leu Lys Asp Glu Ile 
                165                 170                 175     


Leu Glu Glu Ile Leu Glu Asn Leu Asp Asp Glu Leu Ile Val Phe Met 
            180                 185                 190         


Lys Glu Ile Phe Tyr Gln Thr Leu Tyr Val Val Asp Lys Lys Glu Trp 
        195                 200                 205             


Arg Asn Lys Glu Leu Asn Gln Glu Lys Lys Asp Phe Leu Asp Ser His 
    210                 215                 220                 


Leu Ser Ser Lys Glu Asp Trp Ile Asn Trp Ile Leu Phe Asn Cys Val 
225                 230                 235                 240 


Glu Glu Asp Ile Asp Trp Phe Leu Asn Asn Tyr Gly Asp Ser Asp Pro 
                245                 250                 255     


His Pro Asp Ser Lys Asn His Lys His Lys Val Leu Thr Ile Glu Lys 
            260                 265                 270         


Gly Lys His Leu Ser Phe Glu Gly Ser Leu Phe Met Met Thr Met Phe 
        275                 280                 285             


Leu Tyr Ala Asn Glu Ala Asn Tyr Leu Ile Pro Lys Leu Lys Gly Tyr 
    290                 295                 300                 


Lys Lys Asn Gly Thr Pro Gln Asp Ala Ser Lys Leu Glu Val Phe Arg 
305                 310                 315                 320 


Phe Phe Ala Lys Lys Phe Lys Ser Gln Asp Val Asp Ser Glu His Lys 
                325                 330                 335     


Gln Tyr Val Lys Phe Arg Asp Met Ile Gln Tyr Val Gly Lys Tyr Pro 
            340                 345                 350         


Thr Val Trp Asn Lys His Ile His Leu Asp Asn Tyr Tyr Val Asn Glu 
        355                 360                 365             


Leu Lys Val Ser Ile Leu Glu Asn Glu Ile Thr Gln Leu Phe Glu Gln 
    370                 375                 380                 


Asp Ile Gln Asn Tyr Phe Glu Thr Lys Tyr Gly Leu Gln Lys Phe Ala 
385                 390                 395                 400 


Lys Ala Lys Gly Asp Met His Tyr Ala Phe Val Glu Val Ala Lys Ser 
                405                 410                 415     


Tyr Leu Gln Lys Lys Thr Ile Ser Tyr Lys Gly Lys Tyr Gln Asp Asp 
            420                 425                 430         


Ser Ile Ala Ile Leu Glu Thr Leu Ala Glu Gln Ile Thr Asn Lys Arg 
        435                 440                 445             


Gln Leu Lys Asn Ile Glu Val Lys Leu Leu Arg Phe Ser Asp Thr Asp 
    450                 455                 460                 


Tyr Gln Ser Leu Ser Ser Ile Glu Lys Thr Lys Lys Gln Arg Leu Asp 
465                 470                 475                 480 


Lys Ser Lys Lys Met Phe Leu Asp Lys Ile Lys Glu Ser Lys Lys Thr 
                485                 490                 495     


Ile Asn Lys Thr Thr Glu Lys Phe Ala Lys Arg Val Glu Asp Asn Leu 
            500                 505                 510         


Leu Tyr Ile Ser Asn Gly Arg Asn Ser Asp Arg Phe Met Val Phe Ala 
        515                 520                 525             


Cys Arg Phe Leu Ala Glu Ile Asn Tyr Phe Gly Lys Asp Ala Gln Phe 
    530                 535                 540                 


Lys Met Tyr Glu Asn Tyr Tyr Ser Glu Glu Glu Gln Asn Ala Leu Lys 
545                 550                 555                 560 


Asp Lys Lys Gln Asn Leu Thr Gln Lys Asp Phe Asp Lys Leu His Tyr 
                565                 570                 575     


His Trp Gly Lys Leu Thr His Phe Glu Thr Phe Glu Asn His Val Lys 
            580                 585                 590         


Lys Tyr Pro Asn Trp Asp Met Pro Phe Val Val Gln Asn Asn Ala Ile 
        595                 600                 605             


Tyr Val Lys Ile Pro Gly Ile Asn Phe Ile Lys Asn Thr Ala Phe Cys 
    610                 615                 620                 


Ile Arg Arg Asn Val Ile Asn Tyr Leu Leu Glu His Ala Leu Gly Glu 
625                 630                 635                 640 


Asn Tyr Lys Asp Gln Gln Gly Arg Glu Trp Leu Phe Asp Tyr Tyr Glu 
                645                 650                 655     


Tyr Lys Thr Glu Ala Thr Asp Asn Ala Lys Arg Ile Leu Thr Glu Ser 
            660                 665                 670         


Lys Pro Ile Glu Ala Ser Ser Lys Thr Gln Leu Lys Lys Leu Leu Pro 
        675                 680                 685             


Lys Lys Leu Leu Pro Lys His Ser Pro Leu Glu Thr Glu Asn Lys Glu 
    690                 695                 700                 


Asn Ile Phe Arg Lys Tyr Leu Glu Gln Ala Glu Glu Ser Glu Lys Leu 
705                 710                 715                 720 


Tyr Glu Asn Gln Lys Asp Lys Ala Lys Ala Glu Lys Lys Leu Asp Leu 
                725                 730                 735     


Phe Val Asn Lys Asn Lys Gly Lys Gln Phe Lys Leu Arg Phe Ile Phe 
            740                 745                 750         


Lys Ala Trp Gln Leu Met Tyr Phe Lys Lys Gln Tyr Gln Ile Glu Lys 
        755                 760                 765             


Glu Arg Tyr Ala Glu Leu Glu Lys Leu Asp Gly Ile Pro Lys Asn Tyr 
    770                 775                 780                 


Glu His Glu Phe Gly His His Lys Lys Phe Asn Ile Asn Arg Lys Glu 
785                 790                 795                 800 


Phe Asn Leu Phe Ser Lys Trp Leu Phe Ala Met Asp Glu Val Pro Glu 
                805                 810                 815     


Tyr Lys Asn Ser Leu Lys Glu Leu Leu Asp Asp Lys Asn Phe Phe Val 
            820                 825                 830         


Asn Ser Glu Phe Gln Lys Leu Phe Glu Ser Ser Ser Asn Ile Asn Gln 
        835                 840                 845             


Phe Tyr Glu Ser Thr Lys Ser Lys Phe Lys Asn Trp Leu Asn Asp Gln 
    850                 855                 860                 


Gln Val Gln Asn Ile Arg Lys Thr Ile Gln Pro Glu Asn Tyr Tyr Lys 
865                 870                 875                 880 


Met Met Glu Val Gly Asn Phe His Ile Asn Leu Ser His Phe Ile Ala 
                885                 890                 895     


Phe Gly Val Ser His Asp Phe Ile Glu Lys Ser Gly Lys Asn Ile Leu 
            900                 905                 910         


Arg Pro Ile Thr Ser His Ala Lys Tyr Leu Asn Thr Lys Ile Tyr Asp 
        915                 920                 925             


Ile Asp Leu Glu His Ser Asp Ala Ser Asn Leu Glu Lys Asn Ile Phe 
    930                 935                 940                 


Arg Lys Leu Tyr Lys Ile Arg Leu Glu Asp Cys Leu Leu Tyr Glu Ile 
945                 950                 955                 960 


Ala Leu Arg Tyr Phe Gln Pro Asn Leu Asn Leu Arg Gln Lys Ser Tyr 
                965                 970                 975     


Glu Gln Leu Asn Lys Leu Leu Val Gln Lys Ile Ser Ile Ala Ile Lys 
            980                 985                 990         


Ala Asn Asn Ser Gln Thr Tyr Gln  Val Leu Val Pro Phe  Lys Asp Leu 
        995                 1000                 1005             


Glu Lys  Phe Ala Gln Leu Lys  Ala Ile Asp Asp Asn  Thr Gln Asn 
    1010                 1015                 1020             


Lys Phe  Ser Leu Leu Arg Arg  Leu Pro Glu Tyr Leu  Ser Gln Val 
    1025                 1030                 1035             


Asn Glu  Arg Asn Glu Asn Val  Ser Gly Leu Lys Asp  Met Val Glu 
    1040                 1045                 1050             


Ala Phe  Gly Val Asp Lys Ser  Ile Ser Leu Ala Asp  Met Ser Met 
    1055                 1060                 1065             


Leu Tyr  Asn His Leu Ile Thr  Gln Gln Gly Arg Tyr  Thr Asn Cys 
    1070                 1075                 1080             


Ile Met  Ala Leu Glu Glu Tyr  Phe Ile Trp Lys Glu  Lys Phe Thr 
    1085                 1090                 1095             


Ile Glu  Lys Gln Glu Ser Lys  Lys Phe Lys Asn Arg  Ile Val Val 
    1100                 1105                 1110             


Thr Glu  Ile Pro Val Leu Lys  Asp Tyr Phe Lys Arg  Asp Glu Gln 
    1115                 1120                 1125             


Arg Asn  Asn Ala Phe His Met  Asp Leu Pro Ile Asn  Glu Thr Tyr 
    1130                 1135                 1140             


Lys Ser  Thr Phe Lys Ala Ile  Glu Lys Gln Phe Val  Ala Thr Glu 
    1145                 1150                 1155             


Val Asp  Lys Ala Tyr Thr Lys  Leu Asp Asp Cys Pro  Ser Met Leu 
    1160                 1165                 1170             


Lys Asn  Thr Leu Lys Val Phe  Met Asn Gln Met His  Asp Glu Ile 
    1175                 1180                 1185             


Lys Leu  Gly Tyr Lys Pro Asn  Asp Thr Lys Asp Gly  Ile Lys Gln 
    1190                 1195                 1200             


Lys Arg  Thr Val Ala Glu Asn  Thr Phe Phe Lys Gln  Leu Leu Lys 
    1205                 1210                 1215             


Gly Tyr  
    1220 


<210>  2215
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2215

Met Asn Thr His Gln Glu Glu Leu Gln Ser Trp Ile Thr Arg Lys Arg 
1               5                   10                  15      


Leu Pro Asp Thr Glu Met Lys Lys Tyr Trp Ala Ala Tyr Met Asn Leu 
            20                  25                  30          


Ala Arg Leu Asn Phe Phe Lys Thr Leu Met Phe Ile Ser Asn Ser Ile 
        35                  40                  45              


Gly Asp Leu Lys Pro Ala Lys Asp Asn Asn Gly Lys Gly Asn Thr Glu 
    50                  55                  60                  


Val Asn Met His Asn Met Gly Ile Leu Thr Ala Leu Leu Gly Pro Glu 
65                  70                  75                  80  


Asp Glu Glu Lys Ala Arg Leu Leu Ile Phe Lys His Phe Pro Phe Leu 
                85                  90                  95      


Arg Thr Phe Cys Ile Glu Lys Glu Leu Ser Leu Ser Lys Gln Arg Thr 
            100                 105                 110         


Ile Leu Ile Asp Met Ala Cys Ile Ile Gly Arg Tyr Arg Asn Met Tyr 
        115                 120                 125             


Ser His Ser Ile Phe Ile Ser Asp Asp Asn Glu Lys Val Leu Glu Ser 
    130                 135                 140                 


Glu Lys Arg Cys Ser Glu Tyr Leu Gln Ser Ile Leu Thr Val Ser Thr 
145                 150                 155                 160 


Arg Ile Ile Lys Glu Arg Tyr Arg Ser Asn Lys Asn Asp Ala Gln Arg 
                165                 170                 175     


Gly Met Ile Asp Asp Lys Ser Leu Lys Phe Ile Ser Glu Asn Lys Val 
            180                 185                 190         


Lys Phe Val Tyr Asp Glu Asn Gly Lys Arg Ile Thr Ala Pro Asn Lys 
        195                 200                 205             


Lys Tyr Tyr Leu Ser Thr Ile Asp Lys Asp Asn Thr His Leu Ser Tyr 
    210                 215                 220                 


Phe Gly Lys Leu Met Leu Thr Cys Ile Leu Leu Glu Lys Lys Tyr Ala 
225                 230                 235                 240 


Thr Asp Phe Leu Thr Gln Cys His Phe Leu Asp Ala Phe Asn Asp Ser 
                245                 250                 255     


Glu Val Ala Pro Lys Leu Ser Glu Arg Arg Leu Met Leu Glu Val Met 
            260                 265                 270         


Thr Ala Leu Arg Ile Arg Leu Ala Glu Lys Lys Leu Ser Asn Glu Lys 
        275                 280                 285             


Ser Glu Val Gln Ile Ser Leu Asp Ile Leu Asn Glu Leu Lys Lys Cys 
    290                 295                 300                 


Pro Phe Glu Leu Tyr Glu Leu Leu Gly Ser Glu Asp Lys Arg Leu Phe 
305                 310                 315                 320 


Thr Ile Val Ala Asp Thr Gly Glu Thr Ile Leu Leu Arg Arg His Glu 
                325                 330                 335     


Asp Arg Phe Pro Gln Leu Ala Leu Ser Trp Ile Asp Ser Ser Lys Ala 
            340                 345                 350         


Phe Asp His Leu Arg Phe Gln Val Asn Ala Gly Lys Leu Arg Tyr Leu 
        355                 360                 365             


Phe Arg Asp Asn Lys His Cys Ile Asp Gly Gln Thr Arg Met Arg Val 
    370                 375                 380                 


Leu Glu Glu Pro Leu Asn Gly Tyr Arg Arg Leu Met Glu Phe Glu Glu 
385                 390                 395                 400 


Glu Arg Ile Gln Lys Gln Ser Gly Glu Ile Arg Ser Leu Trp Pro Gly 
                405                 410                 415     


Leu Asp Ile Leu Asn Lys Asp Glu Thr Pro Arg Asn Asp Ala Ser Val 
            420                 425                 430         


Leu Pro Tyr Ile Ser Asp Tyr Arg Val Arg Tyr Leu Phe Asp Gly Asp 
        435                 440                 445             


Asn Ile Gly Ile Ser Ile Gly Asp Phe Thr Pro Ser Ile Thr Lys Thr 
    450                 455                 460                 


Asp Glu Thr Lys Tyr Arg Val Thr Gly Lys Thr Ala Asp Cys Cys Leu 
465                 470                 475                 480 


Ser Lys Tyr Glu Leu Pro Gly Leu Leu Phe Tyr His Leu Leu Thr Leu 
                485                 490                 495     


Arg His Gly Asp Asn Lys Arg Ser Thr Lys Asn Ala Glu Asp Ile Ile 
            500                 505                 510         


Ile Asp Ala Ile Lys Arg Tyr Lys Arg Leu Phe Ser Asp Val Lys Glu 
        515                 520                 525             


Gly Ile Leu Lys Pro Ile Lys Glu Glu Asn Ala Asn Gln Leu Gly Asn 
    530                 535                 540                 


Arg Ile Trp Asn Ser Tyr Gly Ile Asn Ile Lys Asp Ile Pro Asp Lys 
545                 550                 555                 560 


Ile Ile Asp Tyr Leu Leu Val Arg Glu Cys Asn Glu Asp Glu Lys Phe 
                565                 570                 575     


Thr Ala Trp Lys Asn Gly Phe Ile Ser Glu Met Leu Gln Ser Thr Lys 
            580                 585                 590         


Asn Arg Ile Lys Arg Phe Glu Lys Asp Ser Glu Ala Val Ile Ser Ser 
        595                 600                 605             


Asp Asn Lys Pro Gly Lys Lys Asn His Val Ser Leu Lys Pro Gly Ala 
    610                 615                 620                 


Tyr Ala Ser Phe Ile Ala Asn Asp Ile Val Phe Phe Gln Glu Cys Gly 
625                 630                 635                 640 


Ala Thr Glu Lys Met Thr Gly Leu Asn Phe Lys Val Met Gln Ser Arg 
                645                 650                 655     


Leu Ala Thr Phe Thr Lys Asp Gly Ser Thr Ser Phe Asn Ile Leu Leu 
            660                 665                 670         


Gln Thr Leu Lys Asn Ala His Leu Val Ser Thr Thr Tyr Gly Lys Gly 
        675                 680                 685             


Asp His Pro Phe Leu Tyr Arg Val Ile Lys Gln Gln Pro Ser Asp Ile 
    690                 695                 700                 


Val Gln Phe Tyr Lys Ile Tyr Leu Asn Glu Lys Val Leu Tyr Leu Gln 
705                 710                 715                 720 


Ser Asp Ile Pro Asp Asn Ala Ile Phe Leu His Gly Glu Arg Lys Arg 
                725                 730                 735     


Trp Glu Asn Arg Asn Glu Gln Tyr Tyr Arg Asp Leu Ala Glu Arg Tyr 
            740                 745                 750         


Leu Gln Arg Pro Ile Gln Leu Pro Arg Gln Leu Phe Glu Ser His Ile 
        755                 760                 765             


Arg Gln Leu Leu Leu Ser Asp Cys Ile Lys Gly Glu Arg Gly Asn Asp 
    770                 775                 780                 


Leu Lys Glu Ala Ile Asn Ser Ala Ala Ser Gln Gly Arg Cys Asn Thr 
785                 790                 795                 800 


Thr Tyr Met Ile Met Glu Tyr Phe Ala Asp Tyr Leu Cys Asp Gly Thr 
                805                 810                 815     


Gln Phe Phe Tyr Gly Leu Phe Asp Gly Asp Leu Ser His Glu Tyr Asn 
            820                 825                 830         


Tyr Arg Phe Tyr Ser Leu Ile Ser Asn Asn Ile Glu Asn Ser Lys Lys 
        835                 840                 845             


Leu Val Leu Thr Leu Lys Lys Gly Asn Asn Ser Lys Glu Ser Pro Phe 
    850                 855                 860                 


Ile Ser Ala Leu Glu Arg Gly Ile His Trp Ser Lys Met Asn Pro Leu 
865                 870                 875                 880 


Met Lys Lys Gly Leu Lys Asn Asp Ser Ser Glu Gly Asp Phe Val His 
                885                 890                 895     


Ala Ala Lys Arg Ala Tyr Lys Glu Met Thr Glu Thr Glu Arg Met Phe 
            900                 905                 910         


Arg Arg Tyr Ala Val Gln Asp Glu Val Leu Phe Leu Ala Ala Lys Ile 
        915                 920                 925             


Thr Ile Arg Arg Val Leu Gly Leu Ser Glu Gln Tyr Asn Cys Leu Leu 
    930                 935                 940                 


Gly Asp Ile Lys Pro Gln Gly Gly Ser Leu Leu Glu Gln Thr Ile Pro 
945                 950                 955                 960 


Ser Ile Thr Thr Lys His Thr Ile Asn Thr Gly Asn Lys Lys Gln Lys 
                965                 970                 975     


Pro Lys Gln Val Gln Ile Leu Gln Lys Asn Val Lys Leu Lys Asp Phe 
            980                 985                 990         


Gly Lys Val Phe Lys Leu Leu Asn  Asp Arg Arg Ile Phe  Asp Leu Leu 
        995                 1000                 1005             


Phe Asn  Lys Gly Asn Glu Ala  Val Ser Met Thr Asp  Leu Cys Glu 
    1010                 1015                 1020             


Glu Leu  Glu Arg Tyr Asp Arg  His Arg Val Asp Val  Phe Asp Ser 
    1025                 1030                 1035             


Val Leu  Lys Tyr Glu Ser Lys  Ile Thr Lys Gly Tyr  Thr Asn Lys 
    1040                 1045                 1050             


Glu Leu  Met Asn Glu Ser Gly  Gln Ile Asp Phe Lys  Ala Ile Gln 
    1055                 1060                 1065             


Ala Phe  Asp Lys Gln Asn Thr  Thr Ala Asp Lys Glu  Asp Leu Arg 
    1070                 1075                 1080             


Leu Ile  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Gln Tyr Asn 
    1085                 1090                 1095             


Asn Glu  Pro Ile Leu Phe Asp  Lys Asp Ile Pro Glu  Ile Ala Asp 
    1100                 1105                 1110             


Glu Ile  Ser Ile Ile Ala Lys  Asp Ile Glu Glu Asn  Thr Lys 
    1115                 1120                 1125         


<210>  2216
<211>  1160
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (223)..(224)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (228)..(228)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (263)..(263)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (267)..(267)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (274)..(274)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (288)..(288)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (312)..(312)
<223>  Xaa can be any naturally occurring amino acid

<400>  2216

Met Lys Asn Glu Ile Leu Thr Asn Ser Lys Ser Leu Lys Ser Asn Pro 
1               5                   10                  15      


Asp Tyr Phe Ser Ala Tyr Leu Asn Met Ala Arg His Asn Ala Tyr Leu 
            20                  25                  30          


Ile Leu Ser His Ile Ser Asp Lys Leu Lys Pro Lys Lys Thr Asn Thr 
        35                  40                  45              


Pro Glu Asp Ala Leu His Ser Ala Tyr Ala Leu Glu Val Leu Lys Ser 
    50                  55                  60                  


Ser Lys Glu Pro Asp Ile Thr Ala Lys Ser Ile Lys Met Leu Asn Glu 
65                  70                  75                  80  


His Phe Pro Phe Leu Lys Val Met Phe Asp Thr Asn Ser Ile Thr Glu 
                85                  90                  95      


Lys Ser Lys Gly Ser Lys Gly Ile Tyr Ser Glu Lys Leu Pro Glu Gln 
            100                 105                 110         


Tyr Leu Asp Lys Met Met Leu Leu Leu Asp His Leu Asn Asn Tyr Arg 
        115                 120                 125             


Asn Ser Tyr Thr His Cys Val His Ile Pro Ile Ile Asn Asp Lys Asn 
    130                 135                 140                 


Phe Ile Tyr Cys Leu Asn Asn Ile Phe Asp Ala Ser Val Arg Thr Val 
145                 150                 155                 160 


Lys Asp Arg Phe Glu Phe Ser Glu Asn Asp Val Ser His Leu Arg Arg 
                165                 170                 175     


Tyr Glu Gln Val Phe Asp Pro Glu Thr Lys Lys Arg Lys Ala Ser Arg 
            180                 185                 190         


Lys Lys Asp Phe Lys Tyr Asn Phe Ile Asp Asn Asp Asp Ile Ser Glu 
        195                 200                 205             


Lys Gly Ile Ala Phe Phe Ile Ala Leu Phe Leu Glu Lys Lys Xaa Xaa 
    210                 215                 220                 


Phe Glu Phe Xaa Lys Lys Leu Ser Asp Phe Lys Asp Ser Arg Thr Lys 
225                 230                 235                 240 


Met Met Gln Ala Thr Leu Glu Ser Tyr Cys Val Tyr His Ile Arg Leu 
                245                 250                 255     


Pro Lys Glu Arg Ile Glu Xaa Thr Gln Asn Xaa Leu Ser Leu Cys Leu 
            260                 265                 270         


Asp Xaa Phe Asn Glu Leu Lys Lys Cys Pro Ser Glu Leu Phe Asp Xaa 
        275                 280                 285             


Leu Lys Lys Glu Asp Ala Glu Lys Phe Arg Ile Lys Pro Asp Ile Asn 
    290                 295                 300                 


Asn Leu Asn Asp Glu Asp Ser Xaa Asn Ile Val Glu Asn Ser Thr Asp 
305                 310                 315                 320 


Asp Tyr Asn Val Glu Pro Ile Leu Lys Arg Tyr Ser Asn Arg Phe Pro 
                325                 330                 335     


Tyr Leu Ala Met Arg Tyr Ile Asp Glu Lys Lys Val Phe Gln Lys Leu 
            340                 345                 350         


Arg Phe His Val Asp Leu Gly Asn Tyr Tyr Phe Lys Phe Tyr Pro Lys 
        355                 360                 365             


Thr Thr Val Asp Gly Glu Lys Arg Asp Arg Ser Leu Lys Val His Leu 
    370                 375                 380                 


Asn Ser Phe Gly Arg Leu Asp Asp Leu Asn His Ala Arg Leu Val Glu 
385                 390                 395                 400 


Trp Asn Asp Leu Ile Arg Phe His Lys Glu Glu Glu Asp Glu Asn Pro 
                405                 410                 415     


Ile Glu Glu Leu Met Pro Tyr Ile Thr Asp Thr Tyr Pro His Tyr His 
            420                 425                 430         


Leu His Asn Asn Gln Ile Gly Leu Lys Asp Thr Gln Asn Asn Pro Asp 
        435                 440                 445             


Lys Leu Leu Pro Lys Ile Glu Arg Glu Lys Thr Lys Thr Glu Gln Pro 
    450                 455                 460                 


Asp Phe Trp Leu Ser Thr Tyr Glu Leu Pro Ala Leu Leu Phe Tyr Ser 
465                 470                 475                 480 


Tyr Leu Leu Lys Lys Lys Arg Asp Ile Ser Ala Glu Asp Leu Ile Leu 
                485                 490                 495     


Asn Cys Arg Lys Lys Tyr His Thr Leu Phe Lys Leu Ile Ser Glu Gly 
            500                 505                 510         


Asn Gly Pro Glu Ile Lys Glu Cys Gln Val Thr Ile Lys Gln Lys Gly 
        515                 520                 525             


Lys Asn Ile Ser Val Phe Leu Leu Thr Ala His Phe Glu Asp Glu Thr 
    530                 535                 540                 


Gly Lys Ser His Glu Ile Glu Leu Asn Asp Leu Pro Gln Val Phe Gln 
545                 550                 555                 560 


Asn Tyr Leu Thr Asp Lys Gln Leu His Asn Arg Glu Glu Leu Ala Glu 
                565                 570                 575     


Asn Lys Ile Asn Arg Leu Ile Ile Glu Thr Glu Arg Arg Arg Glu Lys 
            580                 585                 590         


Ile Asn Lys Asp Leu Glu Arg Ile Asn Gly Leu Lys Gly Asn Lys Arg 
        595                 600                 605             


Gly Lys Lys Asn Phe Val Glu Ile Lys Ser Gly Met Leu Ala Asp Phe 
    610                 615                 620                 


Leu Ala Lys Asp Thr Ile Arg Leu Gln Pro Ser Ile Asp Ala Ile Gly 
625                 630                 635                 640 


Lys Asp Lys Ile Thr Gly Leu Asn Phe Gln Ile Leu Gln Ser His Leu 
                645                 650                 655     


Ala Phe Tyr Gly Arg Asp Phe Leu Met Leu Lys Asp Ile Phe Arg Gln 
            660                 665                 670         


Cys Lys Leu Val Asp Ala Gln Ile Ser His Pro Phe Leu Tyr Lys Leu 
        675                 680                 685             


Asn Pro Glu Asp His Phe Asp Ile Val Ser Phe Tyr Lys Ala Tyr Leu 
    690                 695                 700                 


Gly Glu Arg Lys Lys Tyr Leu Glu Gln Cys Asn Arg Asn Lys Asp Tyr 
705                 710                 715                 720 


Lys Ser Tyr Tyr Phe Leu Lys Phe Asn Ser Gln Lys Phe Thr Thr Glu 
                725                 730                 735     


Thr Ile Glu Tyr Cys Lys Asp Leu Ala Lys Lys Leu Met Asn Thr His 
            740                 745                 750         


Ser Gln Asp Asn His Pro Ile Asn Leu Pro Arg Gly Met Phe Met Asp 
        755                 760                 765             


Ala Ile Ile Asp Trp Phe Lys Lys His Gly Asp Pro Gln Leu Gln Ala 
    770                 775                 780                 


Ile Ala Lys Thr Glu Arg Val Asn Ala Val Tyr Leu Ile Gln Lys Phe 
785                 790                 795                 800 


Phe Glu Phe Lys Lys Asp Ser Asn Gln Pro Phe Tyr Asp Tyr Pro Arg 
                805                 810                 815     


Ser Tyr Asp Phe Ile Asp Lys Leu Glu Asn Phe Asn Asn Met Arg Cys 
            820                 825                 830         


Gly Arg Pro Leu Leu Leu Gln Arg Lys Tyr Tyr Ser Ile Gln Gln Leu 
        835                 840                 845             


Ala Asp Lys Ile Asp Asp Val Lys Thr Arg Ile Thr Lys Leu Pro Glu 
    850                 855                 860                 


Ser Glu Pro Asn Asp Ser His Pro Arg Lys Arg Met Leu Ala Thr Leu 
865                 870                 875                 880 


Ser Asp Tyr Lys Gln Asn Glu Lys Leu Leu Arg Leu Tyr Lys Thr Gln 
                885                 890                 895     


Asp Arg Ile Leu Phe Leu Val Ala Ser Asp Ile Leu Phe Ala Gln Lys 
            900                 905                 910         


Pro Gln Gly Leu Glu Glu Asn Asp Leu Lys Leu Ser Asn Val Lys Pro 
        915                 920                 925             


Lys Pro Glu Asn Asp Ser Asp Glu Asp Leu Leu Ser Ser Gln Leu Pro 
    930                 935                 940                 


Phe Arg Phe Pro Tyr Gln Tyr Trp Asp Val Thr Ser Lys Gly Glu Ile 
945                 950                 955                 960 


Asp His Lys Asn Lys Ile Gly Glu Val Ile Ile Phe Gln Lys Lys Leu 
                965                 970                 975     


Lys Leu Lys Asn Tyr Gly Asp Phe Ile Arg Tyr Thr Lys Asp Arg Arg 
            980                 985                 990         


Leu Asn Asn Leu Phe His Trp Thr  Gly Asp Ile Glu Leu  Glu Met Pro 
        995                 1000                 1005             


Val Leu  Gln Lys Glu Leu Glu  Arg Tyr Glu Glu Ala  Arg Leu Thr 
    1010                 1015                 1020             


Val Phe  Arg Leu Ile His Asp  Phe Glu Lys Ala Met  Tyr Glu Lys 
    1025                 1030                 1035             


His His  Leu Phe Phe Asp Glu  Leu Leu Lys Thr Asn  Lys Leu Lys 
    1040                 1045                 1050             


Lys Glu  Asn Glu Asn Glu Asn  Ser Tyr Ile Asn His  Glu Glu Met 
    1055                 1060                 1065             


Leu Glu  Lys Phe Phe Ser Asp  Tyr Pro Glu Leu Ile  His Tyr Glu 
    1070                 1075                 1080             


Asp Val  Met Leu Thr Ile Arg  Asn Cys Phe Ser His  Asn Gln Tyr 
    1085                 1090                 1095             


Pro Val  Lys Cys Ala Phe Asp  Asn Ile Asp Ser Ile  Gly Leu Phe 
    1100                 1105                 1110             


Glu Gly  Cys Pro Asp Ile Glu  Ser Asp His Asp Asn  Glu Leu Asn 
    1115                 1120                 1125             


Ile Ala  Met Arg Ile Lys Asn  His Ala Ile Ala Thr  Tyr Gly Glu 
    1130                 1135                 1140             


Phe Ile  Lys Ile Leu Thr Asn  Leu Thr Pro Ile His  Asp Ile Asn 
    1145                 1150                 1155             


Val Ser  
    1160 


<210>  2217
<211>  1145
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2217

Met Glu Thr Leu Thr Ile Pro Glu Val Ile Lys Cys Arg Thr Leu Ser 
1               5                   10                  15      


Asp Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Ile Ala Lys Glu Phe Asp Leu Pro Leu 
        35                  40                  45              


Leu Ala Glu Glu Gly His Leu Lys Asn Ser Phe Leu Cys Lys Lys Glu 
    50                  55                  60                  


His Asn Lys Val Asn Trp Asn His Val Tyr Ser Arg Thr Lys Arg Phe 
65                  70                  75                  80  


Leu Ala Val Leu Lys Val Phe Asp Ala Glu Thr Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Lys Thr Ile Asn Trp Glu Gly Lys Asp Phe Ala Ser Met Ser Asp 
            100                 105                 110         


Ile Leu Lys Ile Val Phe Gly Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Thr Ile Arg Lys Thr Ala Val 
    130                 135                 140                 


Ser Ala Glu Met Ala Leu Phe Leu Thr Thr Asn Phe Arg Arg Ala Ile 
145                 150                 155                 160 


Glu Tyr Thr Lys Glu Arg Phe Lys Gly Val Leu Asn Asp Glu Asp Tyr 
                165                 170                 175     


Gln Leu Val Ala Ser Lys Lys Val Leu Glu Ala Asn Ser Thr Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Arg Phe Ile Gly Ile Ile Thr Gly Leu Lys Gly Thr Gln Asn 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro His Asp Arg Phe Gln Ser Asp Asn Pro Arg Gln Ala Phe Ser 
                245                 250                 255     


Leu Asp Leu Ile Asn Glu Leu Asn Arg Cys Pro Lys Val Leu Tyr Asn 
            260                 265                 270         


Ala Ile Thr Glu Glu Gly Lys Gln Lys Leu Arg Ser Ile Pro Gly Glu 
        275                 280                 285             


Leu Glu Asn Lys Asn Leu His Asp Asn Asn Thr Lys Lys Glu Ala Lys 
    290                 295                 300                 


Ile Glu Ala Glu Ala Tyr Glu Leu Tyr Ile Glu Ser Leu Thr Arg Gln 
305                 310                 315                 320 


Ile Arg Tyr Ser Asn Arg Phe Pro Asp Phe Ala Leu Lys Phe Ile Asp 
                325                 330                 335     


Glu Thr Asp Ile Phe Ser Glu Phe Arg Phe Gln Ile Asp Leu Gly Lys 
            340                 345                 350         


Leu Leu Val Asp Glu Tyr Leu Lys Phe Phe Asn Gly Glu His Val Gln 
        355                 360                 365             


Arg Arg Ile Val Glu Asn Ala Lys Ala Phe Gly Lys Leu Ile Asp Phe 
    370                 375                 380                 


Asn Asp Glu Ala Lys Val Met Thr Arg Ile Gly Asn Gly His Phe Ser 
385                 390                 395                 400 


Lys Arg Phe Glu Gln Phe Ala Pro Phe Tyr Asn Thr Glu Asp Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Arg His His Val Thr Ala Lys Leu Gly Pro Asp Ser 
            420                 425                 430         


Lys Gly Glu Pro Glu Lys Lys Leu Leu Gln Pro Leu Pro Glu Ala Phe 
        435                 440                 445             


Leu Ser Leu His Glu Leu Pro Lys Val Ile Leu Leu Asp Tyr Leu Gln 
    450                 455                 460                 


Lys Gly Glu Pro Glu Lys Leu Ile Asn Asp Phe Ile Leu Ile Asn Asn 
465                 470                 475                 480 


Ser Lys Leu Met Asn Met Ser Phe Ile Glu Ala Val Lys Thr Gln Leu 
                485                 490                 495     


Pro Pro Glu Trp Asp Glu Phe Gln Arg Arg Thr Gly Ser Lys Asn Glu 
            500                 505                 510         


Met Pro Tyr Asn Glu Lys Thr Leu Ala Tyr Leu Leu Gln Arg Lys Gln 
        515                 520                 525             


Ile Leu Asn Lys Ile Leu Ala Glu Phe Gln Leu Asn Asp Lys Gln Ile 
    530                 535                 540                 


Pro Gly Arg Ile Leu Asp Tyr Trp Leu Asn Ile Ala Asp Val Glu Glu 
545                 550                 555                 560 


Glu Arg Ala Val Ser Asp Arg Ile Lys Ser Ile Lys Arg Asp Cys Met 
                565                 570                 575     


Ser Arg Leu Arg Ala Leu Gly Lys Phe Lys Ile Asp Arg Asn Arg Asn 
            580                 585                 590         


Lys Ile Pro Lys Ile Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile 
        595                 600                 605             


Val Asp Met Val Val Ser Glu Gly Lys Lys His Lys Ile Thr Ser Phe 
    610                 615                 620                 


Tyr Tyr Glu Lys Met Gln Asp Cys Leu Ser Leu Phe Ala Asp Pro Leu 
625                 630                 635                 640 


Lys Arg Gln Leu Phe Ile His Ile Ile Thr Asn Glu Leu Arg Leu Asn 
                645                 650                 655     


Asp Ser Gly Gly His Pro Phe Leu Phe Lys Leu Asn Met Arg Gln Ile 
            660                 665                 670         


Asn Cys Thr Ser Asp Phe Tyr Glu Ile Tyr Leu Gln Glu Lys Gly His 
        675                 680                 685             


Lys Met Val Pro Glu Lys Asn Leu Lys Thr Gly Lys Val Val Asn Thr 
    690                 695                 700                 


Asp His Ser Trp Met Ala Leu Thr Phe Tyr Lys Leu Glu Phe Asn Asp 
705                 710                 715                 720 


Lys Val Asp Lys Leu Met Thr Val Val Lys Leu Pro Leu Asn Lys Leu 
                725                 730                 735     


Asn Leu Pro Phe Thr Leu Arg Gln Leu Asn Ala Lys Thr Thr Tyr Thr 
            740                 745                 750         


Leu Glu Gln Trp Leu Lys Asn Leu Thr Leu Gly Lys Lys Pro Asp Asp 
        755                 760                 765             


Gly Lys His Pro Val Asn Leu Pro Thr Asn Leu Phe Asp Glu Lys Leu 
    770                 775                 780                 


Ser Asp Leu Leu Arg Gln Asp Leu Asp Asn Asn Lys Ile Ala Tyr Arg 
785                 790                 795                 800 


Pro Tyr Ala Asn Trp Asn Glu Leu Phe Lys Ile Trp Trp Ile Ser Arg 
                805                 810                 815     


Asn Asp Ser Leu Gln Arg Phe Tyr Asn Ala Glu Arg Glu Tyr His Ile 
            820                 825                 830         


Phe Asn Glu Lys Val Asn Phe Tyr Pro Asn Arg Lys Glu Asn Phe Ala 
        835                 840                 845             


Asp Tyr Tyr Gln His Ala Val Lys Val Ala Phe Gln Lys Lys Arg Asn 
    850                 855                 860                 


Glu Arg Ile Ile Glu Gln Arg Ile Asn Lys Tyr Leu Pro Asp Ile Leu 
865                 870                 875                 880 


Phe Glu Gln Val Glu Lys Thr Phe Lys His Thr Ile Ala Glu Thr Glu 
                885                 890                 895     


Lys Glu Ile Arg Ile Leu Gln Glu Glu Asp Arg Ile Met Leu Leu Met 
            900                 905                 910         


Leu Glu Gly Leu Met Glu Asp Gly Asn Lys Gln Gln Leu Lys Leu Ser 
        915                 920                 925             


Glu Ile Lys Thr Leu Gln Asn Ala Thr Ile Asn Ile Arg Gln Leu Val 
    930                 935                 940                 


Pro Gly Lys Leu Ser Phe Asp Asp Ser Gly Glu Ala Ile Lys Asp Ser 
945                 950                 955                 960 


Thr Asn Pro Glu Ile Val Arg Thr Val Ser Val Ser Ile Lys Arg Ile 
                965                 970                 975     


Glu Tyr Asn Leu Leu Pro Lys Tyr Val Ala Asp Gly Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Pro Asp Glu  Glu Ile Gln Met Glu  Arg Leu Lys 
        995                 1000                 1005             


Thr Glu  Phe Asp Thr Tyr Asn  Lys Val Arg Gln Val  Val Leu Asp 
    1010                 1015                 1020             


Leu Ser  Phe Lys Leu Glu Lys  Met Ile Ile Glu Lys  Gly His Lys 
    1025                 1030                 1035             


Asp Arg  Ile Asn Gln Leu Cys  Thr Gly Ala Thr Gly  Glu Leu Leu 
    1040                 1045                 1050             


Thr Gly  Asn Ile Cys His His  Thr Tyr Leu Thr Trp  Leu Lys Asp 
    1055                 1060                 1065             


Lys Glu  Met Ile Asp Asn Glu  Thr Phe Ile Phe Met  Asn Met Val 
    1070                 1075                 1080             


Gln His  Cys Phe Ser His Asn  Gln Tyr Pro Gln Lys  Lys Thr Met 
    1085                 1090                 1095             


Glu Arg  Ile Ile Asn His Trp  Glu Pro Asp Arg Phe  Ala Leu Thr 
    1100                 1105                 1110             


Ile Ala  Ala Thr Tyr Asn Gln  Lys Ile Ala Gly Ile  Leu Glu Asp 
    1115                 1120                 1125             


Ile Gly  Thr Phe Pro Phe Ile  Arg Ser Arg Lys Thr  Met Pro Asp 
    1130                 1135                 1140             


Val Val  
    1145 


<210>  2218
<211>  1274
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2218

Met Glu Thr Pro Asn Lys Thr Ser Thr Ser Ala Tyr Lys Asp Leu Gln 
1               5                   10                  15      


Asn Asp Pro Tyr Tyr Phe Ser His Phe Ile Asn Met Gly Arg His Asn 
            20                  25                  30          


Ala Tyr Leu Ile Ile His Tyr Ile Tyr Lys Cys Val Tyr Lys Glu Glu 
        35                  40                  45              


Leu Asn Leu Ile Glu Ser Asn Leu Tyr Gln Phe Ser Ser Lys Val Lys 
    50                  55                  60                  


Ala Asn Ser Lys Lys Asn Pro Asp Glu Leu Thr Lys Val Ile Arg Leu 
65                  70                  75                  80  


Leu Leu Leu His Phe Pro Phe Leu Ala Tyr Tyr Asp Asn Ala Glu Arg 
                85                  90                  95      


Glu Lys Arg Asp Glu Arg Val Val Gly Arg Ser Asn Asp Gly Asn Trp 
            100                 105                 110         


Asn Lys Lys Val Lys Glu Arg Pro Tyr Leu Ser Asp Lys Asn Thr Val 
        115                 120                 125             


Ser Ser Asn Ser Glu Lys Ala Ser Glu Lys Ala Thr Ser Glu Ser His 
    130                 135                 140                 


Ile Cys Leu Glu Arg Leu Ser Gln Phe Leu Ile Val Leu Asn Asn Leu 
145                 150                 155                 160 


Arg Asn Glu Thr Ser His Tyr Lys His Pro Lys Lys Ser Thr Leu Leu 
                165                 170                 175     


Pro Asp Phe Gln Lys Met Tyr Gln Ser Gly Ile Lys Glu Ala Gln Arg 
            180                 185                 190         


Arg Met Asn Tyr Glu Asp Lys Asp Ile Gln His Leu Phe Lys Asp Pro 
        195                 200                 205             


His Tyr Lys Leu Ile Glu Thr Gln Lys Gln Thr Glu Thr Val Gly Leu 
    210                 215                 220                 


Thr Lys Phe Asn Gly Gln Lys Lys Val Asn Arg Gln Pro Gln Val Asn 
225                 230                 235                 240 


Gly Gln Thr Gly Thr Asp Lys Leu Ala Lys Val Asp Lys Leu Thr Gly 
                245                 250                 255     


Phe Asp Lys Leu Thr Glu Val Asp Glu Leu Gln Asp Leu Asp Glu Leu 
            260                 265                 270         


Thr Glu Ile Gly Ile Tyr Tyr Phe Ile Cys Leu Phe Leu Asp Lys Lys 
        275                 280                 285             


Asn Gly Tyr Leu Leu Leu Ser Arg Ile Arg Gly Phe Lys Asp Arg Asn 
    290                 295                 300                 


Arg Thr Ser Glu Lys Tyr Lys Ser Ala Thr Leu Glu Ala Phe Thr Gln 
305                 310                 315                 320 


Phe His Cys Leu Val Pro Asn Pro Lys Leu Glu Ser Ser Asn Ile Ala 
                325                 330                 335     


Met Asp Met Leu Asn Glu Leu Asn Arg Cys Pro Arg Gln Leu Tyr Gln 
            340                 345                 350         


Val Leu Ser Gln Asp Asp Lys Glu Lys Phe Val Ala Thr Asp Thr Glu 
        355                 360                 365             


Lys Glu Glu Asp Ser Asp Glu Val Pro Glu Pro Ile Met Lys Arg Ser 
    370                 375                 380                 


Glu Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Glu Glu Met Ser 
385                 390                 395                 400 


Arg Leu Gly Leu Ser Gly Thr Leu Asp Gln Ile Thr Phe Gln Leu Phe 
                405                 410                 415     


Leu Gly Arg Lys His Asp Gln Glu Pro His Thr Lys Ile Leu Asn Gly 
            420                 425                 430         


Thr Gln Arg Thr His Ser Leu Leu Lys Asn Met His Val Phe Gly Lys 
        435                 440                 445             


Leu Pro Phe Tyr Gln Lys Glu Glu Ala Tyr Gln Phe Tyr Glu Gly Asn 
    450                 455                 460                 


Glu Glu Val Glu Phe Tyr Ala Pro Ala Tyr Arg Ile Val Gly Asn Arg 
465                 470                 475                 480 


Ile Gly Leu Val Leu Lys Asp Ile His Pro His Tyr Thr Ile Pro Lys 
                485                 490                 495     


Ser Asp Gly Asn Tyr Lys Asn Gly Asn Cys Lys Asn Gly Asn Cys Lys 
            500                 505                 510         


Asn Glu Asn Cys Pro Asp Ala Ile Leu Ser Thr His Glu Leu Ser Ala 
        515                 520                 525             


Leu Phe Phe Tyr Asn Phe Leu His Lys Lys Gly Trp Ile Asp Thr Pro 
    530                 535                 540                 


Thr His Gln Phe Ile Arg Asp Tyr Leu Asp Arg Phe Arg Arg Phe Ile 
545                 550                 555                 560 


Asn Asp Leu Gln Ser Gly Lys Ile Glu Pro Val Asn Glu Asn Gln Ser 
                565                 570                 575     


Ile Lys Lys Ser Lys Arg His Asp Asp Arg Glu Leu Ala Lys Ile Ser 
            580                 585                 590         


Gln Arg Ser Asn Gln Leu Gln Lys Leu Leu Asp Gln Tyr Gly Leu Lys 
        595                 600                 605             


Val Ser Trp Leu Pro Asp Ala Cys Arg Glu Tyr Leu Leu Asn Tyr Gln 
    610                 615                 620                 


Val Pro Ser His Lys Trp Met Val Lys Asp Lys Phe Val Ser Met Lys 
625                 630                 635                 640 


Lys Asp Ala Glu Arg Lys Leu Lys Arg Leu Thr Ser Phe Lys Glu Lys 
                645                 650                 655     


Cys Thr Glu Arg Gly His Gly His Ser Glu Glu Ile Lys Thr Ile Ser 
            660                 665                 670         


Leu Lys Asn Lys Gln Ile Arg Ile Gly Glu Leu Ala Gln Glu Leu Ala 
        675                 680                 685             


Arg Asp Leu Val Phe Leu Thr Pro Pro Gln Thr Ala Gln Asn Ser Asp 
    690                 695                 700                 


Ala Lys Lys Lys Ile Asn Asn Leu Glu Phe Asp Ile Leu Gln Lys Met 
705                 710                 715                 720 


Leu Ala Tyr Phe Pro Ser Tyr Lys Asp Glu Leu Lys Pro Phe Leu Glu 
                725                 730                 735     


Ile Leu Lys Glu Lys Asp Asn Arg Trp Lys His Pro Phe Leu Gly Lys 
            740                 745                 750         


Ile Val Thr Arg Lys Tyr Ser Ser Cys Ser Ser Leu Thr Asp Leu Tyr 
        755                 760                 765             


Lys Ala Tyr Tyr Glu Gln Lys Ile Asp Trp Ile Asp Thr Glu Ile Leu 
    770                 775                 780                 


Lys Arg Ser Thr Asn Arg Asp Arg Lys Thr Thr Val Ser Leu Arg Arg 
785                 790                 795                 800 


Glu Ala Glu Glu Ile Ala Ser Gln Tyr Glu Tyr Ile Leu Lys Leu Asp 
                805                 810                 815     


Arg Lys Thr Lys Pro Ala Thr Glu Lys Ile Tyr Ser Glu Glu Ala Val 
            820                 825                 830         


Tyr Leu Pro Thr Gly Leu Phe Glu Glu Ser Ile Val Arg Ala Ile Lys 
        835                 840                 845             


Gln His Ser Thr Glu Leu Gly Ile Asp Ile Lys Ser Gly Ser Asn Val 
    850                 855                 860                 


Ala Gly Cys Leu Met Ala Tyr Cys Asn Asn Val Lys Gln Pro Met Tyr 
865                 870                 875                 880 


Ser Leu Pro Arg Tyr Tyr Asn Ala Lys Glu Leu Gly Tyr Lys Asp Ala 
                885                 890                 895     


Val Leu Arg Asp Glu Ile Lys Glu Lys Ile Ser Glu Phe Phe Ser Lys 
            900                 905                 910         


Gln Ser Lys Lys Asn Val Arg Met Thr Pro Thr Asp Lys Lys Val Leu 
        915                 920                 925             


His Glu Lys Glu Asn Glu Met Lys Asn Leu Ala Lys Arg Ile Lys Glu 
    930                 935                 940                 


Asn Glu Ala Glu Ile Leu Arg Gln Gln Asn Asn Asp Arg Ala Leu Phe 
945                 950                 955                 960 


Leu Met Val Asn Asp Leu Leu Pro Ala Ser Leu Lys Gly Asp Pro Thr 
                965                 970                 975     


Arg Pro Gly Asp Glu Ile Thr Glu Leu Gly Arg Leu Gly Phe Asp Gln 
            980                 985                 990         


Gln His Asn Met Leu Asp Arg Glu  Tyr Glu Met Cys Glu  Thr Ile Tyr 
        995                 1000                 1005             


Gly Arg  Lys Val Thr Ala Val  Leu Pro Ile Lys Arg  Tyr Gly Glu 
    1010                 1015                 1020             


Phe Arg  Arg Phe Leu Lys Asp  Arg Arg Leu Glu Asn  Leu Leu Lys 
    1025                 1030                 1035             


Tyr Tyr  Pro Glu Gly Ala Glu  Ile Arg Leu Gly Ala  Met Arg Ser 
    1040                 1045                 1050             


Gly Cys  Thr Gln Gln Lys Gly  Glu Lys Phe Lys Asp  Ser Asn Leu 
    1055                 1060                 1065             


Ser Glu  Glu Ile Glu Ile Tyr  Asp Met Glu Arg Asp  Lys Leu Leu 
    1070                 1075                 1080             


Lys Leu  Ile Tyr Asp Phe Glu  Lys Leu Leu Ile Asp  His Tyr Ala 
    1085                 1090                 1095             


Asp Glu  Ile Thr Lys Thr Lys  Asp Gln Tyr Tyr Asn  His Thr Asn 
    1100                 1105                 1110             


Cys Leu  Ile Ala Ala Gln Lys  Leu Gly Ile Asn Ile  Asp Pro Glu 
    1115                 1120                 1125             


Leu Leu  Leu Glu Glu Glu Glu  Met Glu Asn Glu Ile  Lys Val Ala 
    1130                 1135                 1140             


Asp Gln  Asn Arg Asp Gln Asn  Arg Asp Lys Asp Gly  Asn Lys Asn 
    1145                 1150                 1155             


Asp Val  Arg Pro Phe Glu Glu  Lys Pro Asn Ser Cys  Ser Glu Gly 
    1160                 1165                 1170             


Asn Asp  Lys Gly Tyr Leu Cys  Tyr Glu Asn Arg Glu  Lys Glu Ser 
    1175                 1180                 1185             


Val Ser  Pro Glu Asn Asp Ser  Lys Gln Val Ala Asn  Gln Ser Asn 
    1190                 1195                 1200             


Gly Lys  Lys Gly Asn Asn Cys  Asn Leu Gly Glu Leu  Arg Arg Lys 
    1205                 1210                 1215             


Leu Ile  His Asn Glu Ile Pro  Tyr Glu Pro Trp Ile  Glu Lys Glu 
    1220                 1225                 1230             


Ile Asn  Lys Arg Lys Asp Glu  Pro Met Ile Thr Lys  Arg Ile Val 
    1235                 1240                 1245             


Cys Leu  Val Ser Asp Ile Tyr  Ser Gln Leu Val Glu  Ser Leu Gln 
    1250                 1255                 1260             


Ala Met  Val Asp Gln Asn Glu  Gly Lys Gln Trp 
    1265                 1270                 


<210>  2219
<211>  1126
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2219

Met Glu Thr Asn Gln Lys Pro Asn Tyr Lys Lys Phe Thr Asn Glu Gln 
1               5                   10                  15      


Asp Lys Pro Phe Phe Ser Gly Tyr Leu Asn Thr Ala Lys Gln Asn Val 
            20                  25                  30          


Phe Ile Ile Phe Arg Asp Ile Ser Glu Arg Leu Gly Leu Gly Phe Asp 
        35                  40                  45              


Leu Ser Asn Asp Asp Asn Ile Met Asn Ala Asp Leu Trp Glu Tyr Leu 
    50                  55                  60                  


Lys Asn Asn Lys Arg Pro Glu Ile Thr Gln His Ile Ile Glu Lys Leu 
65                  70                  75                  80  


Met Tyr His Phe Pro Phe Ala Ser His Leu Thr Thr Asn Tyr Ala Tyr 
                85                  90                  95      


Tyr Lys Arg Lys Glu Asn Gln Ala Glu Pro Leu Asp Tyr Tyr Glu Ile 
            100                 105                 110         


Phe Glu Leu Leu Ile Lys Gln Leu Tyr Glu Tyr Arg Asn Phe Tyr Thr 
        115                 120                 125             


His Val Val His Asp Pro Val Ile Met Asn Lys Val Ile Ile Asn Gly 
    130                 135                 140                 


Met Arg Ile Leu Phe Asp Ala Ala Arg Ile Glu Val Lys Asp Arg Phe 
145                 150                 155                 160 


Asn Leu Lys Thr Glu Asp Val Asn His Leu Val Arg Leu Gly Pro Lys 
                165                 170                 175     


Gly Lys Glu Asn Lys Asn Phe Tyr Tyr Asn Phe Ser Asp Asp Glu Arg 
            180                 185                 190         


Asn Val Ser Glu Lys Gly Leu Ala Phe Phe Ile Cys Leu Gly Leu Gln 
        195                 200                 205             


Arg Lys Asp Ala Gln Ile Phe Leu Lys Ser Leu Val Gly Phe Lys Leu 
    210                 215                 220                 


Ser Glu Ser Pro Ser Gln Lys Ala Thr Leu Glu Val Tyr Thr Asn Tyr 
225                 230                 235                 240 


Ser Pro Arg Ile Pro Gln Pro Arg Leu Thr Ser Asp Asn Ser Ile Glu 
                245                 250                 255     


Gly Leu Leu Leu Asp Met Val Asn Glu Leu Lys Arg Cys Pro Lys Glu 
            260                 265                 270         


Leu Tyr His Leu Leu Ser Ile Glu Asp Arg Glu Lys Phe Lys Ala Val 
        275                 280                 285             


Lys Glu Asp Asn Thr Tyr Asp Asp Asn Asp Glu Tyr Glu Ala Met Pro 
    290                 295                 300                 


Val Leu Lys Arg Ser Arg Asn Arg Phe Phe Tyr Phe Ala Leu Arg Tyr 
305                 310                 315                 320 


Leu Asp Asn Asn Leu Gln Asn Ile Lys Phe His Ile Asp Leu Gly Asn 
                325                 330                 335     


Tyr Cys Phe His Val Tyr Glu Gln Glu Ile Glu Glu Ile Val Arg Lys 
            340                 345                 350         


Arg Arg Trp Ile Lys Arg Met Thr Ser Phe Gly Asn Leu Glu Asp Phe 
        355                 360                 365             


Ala Asp Lys Met Arg Pro Ala Tyr Trp Val Glu Lys Thr Leu Lys Leu 
    370                 375                 380                 


Glu Asp Lys Lys Val Asp Asn Pro Asn Ile Tyr Ile Thr Asp Thr Thr 
385                 390                 395                 400 


Pro His Tyr His Ile Asn Gly Gln Asn Ile Gly Ile Lys Phe Ile Asn 
                405                 410                 415     


Asn Tyr Val Ala Leu Arg Lys Asn Asn Lys Ile Trp Pro Glu Leu Pro 
            420                 425                 430         


Asp Phe Gly Asp Asn Asn Lys Thr Asn Lys Pro Arg Asn Glu Thr Pro 
        435                 440                 445             


Asp Cys Trp Leu Ser Leu Tyr Glu Leu Pro Ser Ile Val Phe Tyr His 
    450                 455                 460                 


Leu Leu Lys Gln Gln Asn Ile Gly Leu Pro Ser Val Glu Arg Ile Ile 
465                 470                 475                 480 


Asn Asp His Arg Asn Gln Ile Arg Gly Phe Phe Asn Asp Leu Glu Asn 
                485                 490                 495     


Asn Arg Ile Val Pro Ser Phe Thr Asp Thr Thr Leu Lys Ala Glu Leu 
            500                 505                 510         


Lys Asn Arg Gly Leu Lys Lys Ser Gln Ile Pro Ser Ala Ile Val Lys 
        515                 520                 525             


Tyr Leu Thr Ser Lys Pro Val Met Ser Phe Glu Ala Lys Ala Ser Lys 
    530                 535                 540                 


Arg Leu Ser Glu Leu Val Thr Glu Thr Ser Glu Lys Leu Asp Lys Ile 
545                 550                 555                 560 


Lys Arg Gln Glu Gln His Tyr Leu Lys Lys Pro Gly Ser Lys Asp Tyr 
                565                 570                 575     


Ile Asp Met Lys Cys Gly His Leu Ala Asp Phe Leu Ala Arg Asp Met 
            580                 585                 590         


Ile Ser Leu Gln Lys Pro Tyr Asn Asn Met Asp Gly Lys Ala Asn Ser 
        595                 600                 605             


Thr Glu Phe Gln Ile Leu Gln Ser Lys Leu Ala Tyr Phe Gly Lys Asn 
    610                 615                 620                 


Lys Asp Ser Leu Ser Lys Thr Phe His Leu Phe Asn Leu Met Gly Ser 
625                 630                 635                 640 


Gln Asn Ile His Pro Phe Leu Tyr Lys Ile Asp Ile Asn Gln Cys Ile 
                645                 650                 655     


Gly Ile Leu Asp Phe Tyr Lys Lys Tyr Leu Asp His Arg Tyr Ile Tyr 
            660                 665                 670         


Phe Lys Gln Cys Leu Asn Glu Lys Arg Tyr Ser Glu Tyr His Phe Leu 
        675                 680                 685             


Lys Leu Gly Gly Lys Ser Lys Glu Gln Gly Arg Asp Tyr Phe Val Lys 
    690                 695                 700                 


Leu Ala Asn Thr Leu Gln Lys Glu Thr Val Met Asn Leu Pro Arg Gly 
705                 710                 715                 720 


Leu Phe Leu Glu Ser Ile Ile Arg Ile Leu Lys Ala Asn Asp Asn Ser 
                725                 730                 735     


Arg Pro Phe Ala Ile Glu Ile Glu Lys Met Glu Arg Val Asn Ala Ala 
            740                 745                 750         


Tyr Val Ile Asp Gln Tyr Leu Gly Arg Ile Leu Asn Asp Lys Pro Gln 
        755                 760                 765             


Val Phe Tyr Ser Tyr Asn Lys Ser Tyr Glu Phe Leu Asn Lys Leu Phe 
    770                 775                 780                 


Asp Ser Arg Lys Ile Ser Glu Lys Arg Asn Ala Leu Pro Glu Val Tyr 
785                 790                 795                 800 


Phe Asp Thr Gly Glu Leu Ala Lys Lys Thr Thr Ile Ser Val Lys Gly 
                805                 810                 815     


Gln Lys Asp Asn Glu Ile Thr Arg Ser Leu Thr Lys Thr Val Glu Gln 
            820                 825                 830         


His Ile Lys Arg Asn Arg Ile Phe Asp Glu Lys Glu Lys Thr Lys Val 
        835                 840                 845             


Tyr Asp Gln Tyr Met Ala Arg Tyr Asn Asp Phe Thr Glu Asn Glu Lys 
    850                 855                 860                 


Gln Ile Arg Leu Ala Lys Thr Cys Asp Glu Val Met Phe Met Met Ile 
865                 870                 875                 880 


Asp Asp Ile Phe Arg Lys Tyr Phe Val Leu Asp Asn Gly Thr Leu Lys 
                885                 890                 895     


Lys Lys Thr Ile Glu Ala Ile Pro Phe Ile Gln Leu Gly Asp Asp Tyr 
            900                 905                 910         


Lys Leu Gly Ser Ile Lys Pro Asp Ser Glu Lys Gly Phe Leu Ser Leu 
        915                 920                 925             


Gln Thr Thr Val Lys Leu Gln Met Pro Phe Thr Tyr Glu Thr Asn Thr 
    930                 935                 940                 


Asp Lys Val Leu Lys Val Lys Gly Ala Glu Ser Lys Leu Ser Ala Arg 
945                 950                 955                 960 


Tyr Ile Lys Thr Ile Val Arg Glu Thr Ile Lys Ile Lys Asn Tyr Gly 
                965                 970                 975     


Asp Phe Arg Ala Phe Leu Lys Asp Arg Arg Ile Ser Ser Leu Leu Pro 
            980                 985                 990         


Tyr Leu Ser Asp Arg Glu Ile His  Tyr Glu Ala Leu Gln  Lys Glu Leu 
        995                 1000                 1005             


Glu Leu  Phe Gln Lys Ala Arg  Met Glu Val Phe Asp  Arg Ile Phe 
    1010                 1015                 1020             


Arg Phe  Glu Lys Asp Ile Thr  Gly Ala Phe His Ile  Pro Lys Asn 
    1025                 1030                 1035             


Lys Asn  Gly Tyr Ile Tyr His  Thr Glu Ile Leu Lys  Gln Lys Ile 
    1040                 1045                 1050             


Asn Glu  Gly Asp Glu Arg Phe  Gly Phe Ile Lys Glu  Leu Arg Asn 
    1055                 1060                 1065             


Ala Phe  Asn His Ser Asn Tyr  Pro Ala Tyr Val Leu  Phe Lys Asp 
    1070                 1075                 1080             


Phe Ile  Asp Gly Ser Gln Phe  Asn Glu Leu Arg Asn  Tyr Lys Ser 
    1085                 1090                 1095             


Gly Asp  Thr Glu Val Glu Asn  Lys Ser Val Ile Leu  Gln Phe Lys 
    1100                 1105                 1110             


Asn Leu  Leu Ile Gln Tyr Tyr  Asp Glu Leu Thr Asp  Leu 
    1115                 1120                 1125     


<210>  2220
<211>  909
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2220

Met Lys Met Phe Tyr Lys Ser Val Leu Thr Ala Phe Phe Thr Ala Val 
1               5                   10                  15      


Asp Ser Leu Arg Asn Lys Tyr Thr His Tyr Ser His Lys Asp Leu Asn 
            20                  25                  30          


Ile Arg Glu Ile Lys Ile Glu Cys Thr Leu Gly Gly Lys Asp Tyr Cys 
        35                  40                  45              


Ile Gly Leu Leu Asn Ala Leu Asp Cys Ile Tyr Asp Ser Ala Val Asn 
    50                  55                  60                  


Leu Leu Lys Leu Arg Phe Met Ala Gly Glu Asp Glu Val Ala His Leu 
65                  70                  75                  80  


Arg Arg Cys Lys Ala Val Asn Lys Lys Val Val Val Arg Thr Glu Lys 
                85                  90                  95      


Asp Gly Phe Tyr Tyr Arg Leu Ser Asp Asn Gly Gly Val Thr Glu Lys 
            100                 105                 110         


Gly Val Ile Phe Ile Ala Ser Met Phe Leu Asn Arg Lys Tyr Gly Phe 
        115                 120                 125             


Leu Phe Leu Lys Gln Leu Glu Gly Phe Lys Arg Ser Asp Glu Lys Arg 
    130                 135                 140                 


Tyr Arg Leu Thr Leu Glu Ala Phe Leu Ala Phe Ser Asn Ile Lys Pro 
145                 150                 155                 160 


Val Asp Arg Leu Lys Ser Asp Lys Leu Asp Arg Ala Ser Leu Gly Leu 
                165                 170                 175     


Asp Met Leu Asn Glu Leu Thr Lys Ile Pro Lys Glu Leu Ser Glu Thr 
            180                 185                 190         


Leu Ser Val Asp Cys Leu Tyr Lys Tyr Leu Ala Ser Asp Gly Glu Asp 
        195                 200                 205             


Asp Leu Arg Ser Arg Ile Arg Tyr Gln Asp Arg Phe Val Pro Leu Ala 
    210                 215                 220                 


Leu Glu Phe Ile Ser Gln Ser Asp Glu Phe Lys Asp Phe Arg Phe Tyr 
225                 230                 235                 240 


Thr Tyr Val Gly Asn Tyr Val Tyr Lys Gly Tyr Ile Lys Arg Leu Ile 
                245                 250                 255     


Asp Gly Thr Asp Lys Glu Arg Tyr Leu Ser Asp Arg Leu Cys Gly Phe 
            260                 265                 270         


Tyr Lys Ser Val Asn Asp Ala Ser Ser Asp Ala Ile Ala Gln Lys Tyr 
        275                 280                 285             


Gly Val Glu Ile Lys Asp Ser Asn Glu Pro Asp Tyr Met Leu Pro Asp 
    290                 295                 300                 


Ser Phe Arg Pro His Val Leu Arg Ala Thr Pro His Phe Val Ile Asn 
305                 310                 315                 320 


Thr Asn Asn Ile Gly Ile Lys Ile Cys Gly Asn Asp Cys Leu Pro Ile 
                325                 330                 335     


Val Asn Gly Lys Gly Val Glu Ser Pro Glu Pro Asp Tyr Trp Leu Ser 
            340                 345                 350         


Ile Tyr Glu Leu Pro Ala Met Leu Phe Tyr Ala Tyr Leu Arg Glu Lys 
        355                 360                 365             


Asn Gly Lys Arg Phe Lys Asp Tyr Lys Ser Ile Arg Glu Leu Ile Glu 
    370                 375                 380                 


Gly Val Glu Lys Lys Ala Asp Glu Lys Asn Asp Arg Asp Lys Gly Ala 
385                 390                 395                 400 


Leu Met Ala Arg His Ile Asp Lys Glu Ile Ile Trp Thr Gln Thr Lys 
                405                 410                 415     


Leu Asp Glu Val Lys Arg Leu Glu Glu Lys Lys Val Ala Ala Tyr Gly 
            420                 425                 430         


Lys Lys Gly Arg Val Val Leu Lys Ala Gly Arg Met Ala Asp Leu Leu 
        435                 440                 445             


Ala His Asp Met Val Arg Leu Gln Pro Ala Thr Lys Gly Ser Asp Lys 
    450                 455                 460                 


Ile Thr Gly Ala Asn Phe Gln Ala Leu Gln Val Ser Leu Ala Tyr Phe 
465                 470                 475                 480 


Lys Arg Asp Ile Leu Ala Asp Val Phe Ser Arg Ala Met Leu Thr Thr 
                485                 490                 495     


Gly Asn His Arg His Pro Phe Leu Tyr Arg Ile Asp Val Ser His Cys 
            500                 505                 510         


Ser Ser Leu Arg Asp Phe Tyr Val Ala Tyr Leu Gly Glu Arg Arg Lys 
        515                 520                 525             


Tyr Phe Glu Asp Val Ala Lys Lys Ile Ala Lys Asn Lys Leu Asn Thr 
    530                 535                 540                 


Pro Cys His Ile Leu Arg Arg Leu Gln Arg Glu Gly Ser Gly Glu Glu 
545                 550                 555                 560 


Ala Gly Lys Asp Val Lys Pro Lys Phe Leu Pro Arg Gly Ile Phe Thr 
                565                 570                 575     


Asp Ser Ile Lys Asn Cys Leu Glu Gln Ser Lys Leu Asn Ile Tyr Ile 
            580                 585                 590         


Arg Asn Ala Arg Asn Asp Val Lys Pro Ala Ile Asn Ala Ala Tyr Leu 
        595                 600                 605             


Ile Leu Met Tyr Tyr Lys Glu Ile Glu Lys Gly Glu Phe Gln Gly Phe 
    610                 615                 620                 


Tyr Gly Glu Lys Arg Arg Tyr Asp Ile Leu Glu Glu Gly Lys Pro Leu 
625                 630                 635                 640 


Asp Leu Ala Glu Arg Lys Lys Ala Leu Ala Ser Ile Lys Pro Ala Lys 
                645                 650                 655     


Ile Asp Val Ser Glu Ala Asn Met Pro Met Ser Lys Glu Glu His Leu 
            660                 665                 670         


Met Arg Lys Arg Tyr His Ala Val Cys Asn Asn Glu Ser Ala Ile Arg 
        675                 680                 685             


Met Tyr Gln Val Gln Asp Ile Leu Leu Leu Leu Met Ala Lys Asp Ile 
    690                 695                 700                 


Phe Lys Lys Ala Leu Ser Glu Gly Val Met Ser Lys Lys Ile Gly Leu 
705                 710                 715                 720 


Glu Asn Leu Asn Gly Ile Phe Asp Ala Pro Val Asn Phe Val Lys Asn 
                725                 730                 735     


Phe Asp Asn Ile Lys Leu Thr Ala Thr Gly Ile Lys Ile Lys Asp Tyr 
            740                 745                 750         


Gly Lys Val Cys Arg Leu Gly Thr Asp Phe Lys Phe Asn Ser Leu Ile 
        755                 760                 765             


Lys Ala Phe His Lys Val Tyr Ser Lys Ser Val Glu Met Asp Tyr Ser 
    770                 775                 780                 


Asp Tyr Leu Lys Glu Glu Glu Glu Phe Glu Lys Tyr Arg Leu Asn Met 
785                 790                 795                 800 


Val Lys Leu Cys Arg Glu Val Glu Arg Gly Ile Thr Glu Asp Leu His 
                805                 810                 815     


Leu Ser Leu Asp Gly Lys Ser His Leu Ser Phe Asn Asp Asp Val Ile 
            820                 825                 830         


Lys Pro Tyr Asn Asp Lys Tyr Asn Val Phe Asn Gly Gly Asp Leu Thr 
        835                 840                 845             


Phe Phe Ile Asn Ala Arg Asn Met Phe Met His Gly Asp Tyr Lys Tyr 
    850                 855                 860                 


Glu Cys Val Lys Tyr Val Val Ser Glu His Phe Lys Gly Ser Leu Asn 
865                 870                 875                 880 


Asp Val Ser Phe Ala Lys Glu Thr Tyr Gly His Phe Cys Asn Leu Leu 
                885                 890                 895     


Glu Ser Met Arg Lys Lys Thr Gly Leu Arg Ile Asp Ile 
            900                 905                 


<210>  2221
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2221

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2222
<211>  1179
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2222

Met Ser Ser Lys Asn Glu Ser Tyr Asn Lys Gln Lys Thr Phe Asn His 
1               5                   10                  15      


Tyr Lys Gln Glu Asp Lys Tyr Phe Phe Gly Gly Phe Leu Asn Asn Ala 
            20                  25                  30          


Asp Asp Asn Leu Arg Gln Val Gly Lys Glu Phe Lys Thr Arg Ile Asn 
        35                  40                  45              


Phe Asn His Asn Asn Asn Glu Leu Ala Ser Val Phe Lys Asp Tyr Phe 
    50                  55                  60                  


Asn Lys Glu Lys Ser Val Ala Lys Arg Glu His Ala Leu Asn Leu Leu 
65                  70                  75                  80  


Ser Asn Tyr Phe Pro Val Leu Glu Arg Ile Gln Lys His Thr Asn His 
                85                  90                  95      


Asn Phe Glu Gln Thr Arg Glu Ile Phe Glu Leu Leu Leu Asp Thr Ile 
            100                 105                 110         


Lys Lys Leu Arg Asp Tyr Tyr Thr His His Tyr His Lys Pro Ile Thr 
        115                 120                 125             


Ile Asn Pro Lys Ile Tyr Asp Phe Leu Asp Asp Thr Leu Leu Asp Val 
    130                 135                 140                 


Leu Ile Thr Ile Lys Lys Lys Lys Val Lys Asn Asp Thr Ser Arg Glu 
145                 150                 155                 160 


Leu Leu Lys Glu Lys Leu Arg Pro Glu Leu Thr Gln Leu Lys Asn Gln 
                165                 170                 175     


Lys Arg Glu Glu Leu Ile Lys Lys Gly Lys Lys Leu Leu Glu Glu Asn 
            180                 185                 190         


Leu Glu Asn Ala Val Phe Asn His Cys Leu Arg Pro Phe Leu Glu Glu 
        195                 200                 205             


Asn Lys Thr Asp Asp Lys Gln Asn Lys Thr Val Ser Leu Arg Lys Tyr 
    210                 215                 220                 


Arg Lys Ser Lys Pro Asn Glu Glu Thr Ser Ile Thr Leu Thr Gln Ser 
225                 230                 235                 240 


Gly Leu Val Phe Leu Met Ser Phe Phe Leu His Arg Lys Glu Phe Gln 
                245                 250                 255     


Val Phe Thr Ser Gly Leu Glu Gly Phe Lys Ala Lys Val Asn Thr Ile 
            260                 265                 270         


Lys Glu Glu Glu Ile Ser Leu Asn Lys Asn Asn Ile Val Tyr Met Ile 
        275                 280                 285             


Thr His Trp Ser Tyr Ser Tyr Tyr Asn Phe Lys Gly Leu Lys His Arg 
    290                 295                 300                 


Ile Lys Thr Asp Gln Gly Val Ser Thr Leu Glu Gln Asn Asn Thr Thr 
305                 310                 315                 320 


His Ser Leu Thr Asn Thr Asn Thr Lys Glu Ala Leu Leu Thr Gln Ile 
                325                 330                 335     


Val Asp Tyr Leu Ser Lys Val Pro Asn Glu Ile Tyr Glu Thr Leu Ser 
            340                 345                 350         


Glu Lys Gln Gln Lys Glu Phe Glu Glu Asp Ile Asn Glu Tyr Met Arg 
        355                 360                 365             


Glu Asn Pro Glu Asn Glu Asp Ser Thr Phe Ser Ser Ile Val Ser His 
    370                 375                 380                 


Lys Val Ile Arg Lys Arg Tyr Glu Asn Lys Phe Asn Tyr Phe Ala Met 
385                 390                 395                 400 


Arg Phe Leu Asp Glu Tyr Ala Glu Leu Pro Thr Leu Arg Phe Met Val 
                405                 410                 415     


Asn Phe Gly Asp Tyr Ile Lys Asp Arg Gln Lys Lys Ile Leu Glu Ser 
            420                 425                 430         


Ile Gln Phe Asp Ser Glu Arg Ile Ile Lys Lys Glu Ile His Leu Phe 
        435                 440                 445             


Glu Lys Leu Gly Leu Val Thr Glu Tyr Lys Lys Asn Val Tyr Leu Lys 
    450                 455                 460                 


Glu Thr Ser Asn Ile Asp Leu Ser Arg Phe Pro Leu Phe Pro Ser Pro 
465                 470                 475                 480 


Ser Tyr Val Met Ala Asn Asn Asn Ile Pro Phe Tyr Ile Asp Ser Lys 
                485                 490                 495     


Ser Asn Asn Leu Asp Glu Tyr Leu Asn Gln Lys Lys Lys Ala Gln Ser 
            500                 505                 510         


Gln Asn Arg Lys Arg Asn Leu Thr Phe Glu Lys Tyr Asn Lys Glu Gln 
        515                 520                 525             


Ser Lys Asp Ala Ile Ile Ala Met Leu Gln Lys Glu Ile Gly Val Lys 
    530                 535                 540                 


Asp Leu Gln Gln Arg Ser Thr Ile Gly Leu Leu Ser Cys Asn Glu Leu 
545                 550                 555                 560 


Pro Ser Met Leu Tyr Glu Val Ile Val Lys Asp Ile Lys Gly Ala Glu 
                565                 570                 575     


Leu Glu Asn Lys Ile Ala Gln Lys Ile Arg Glu Gln Tyr Gln Ser Ile 
            580                 585                 590         


Arg Asp Phe Thr Leu Asp Ser Pro Gln Lys Asp Asn Ile Pro Ala Thr 
        595                 600                 605             


Leu Thr Lys Thr Ile Ser Thr Asp Thr Ser Val Thr Phe Glu Asn Gln 
    610                 615                 620                 


Pro Ile Asp Ile Pro Arg Leu Lys Asn Ala Ile Gln Lys Glu Leu Ala 
625                 630                 635                 640 


Leu Thr Gln Glu Lys Leu Leu Asn Val Lys Gln His Glu Ile Glu Val 
                645                 650                 655     


Asp Asn Tyr Asn Arg Asn Lys Asn Thr Tyr Lys Phe Lys Asn Gln Pro 
            660                 665                 670         


Lys Asp Lys Val Asp Asp Asn Lys Leu Gln Arg Lys Tyr Val Phe Tyr 
        675                 680                 685             


His Asn Glu Ile Gly Gln Glu Ala Asn Trp Leu Ala Ser Asp Leu Ile 
    690                 695                 700                 


His Phe Met Lys Asn Lys Ser Leu Trp Lys Gly Tyr Met His Asn Glu 
705                 710                 715                 720 


Leu Gln Ser Leu Leu Ala Phe Phe Glu Asp Lys Lys Asn Asp Cys Ile 
                725                 730                 735     


Ala Leu Leu Glu Thr Val Phe Asn Leu Lys Glu Asp Cys Ile Leu Thr 
            740                 745                 750         


Lys Asp Leu Lys Asn Leu Phe Leu Lys His Gly Asn Phe Ile Asp Phe 
        755                 760                 765             


Tyr Lys Glu Tyr Leu Lys Leu Lys Glu Asp Phe Leu Ser Thr Glu Ser 
    770                 775                 780                 


Thr Phe Leu Glu Asn Gly Phe Ile Gly Leu Pro Pro Lys Ile Leu Lys 
785                 790                 795                 800 


Lys Glu Leu Ser Lys Arg Leu Asn Tyr Ile Phe Ile Val Phe Gln Lys 
                805                 810                 815     


Arg Gln Phe Ile Ile Lys Glu Leu Glu Glu Lys Lys Asn Asn Leu Tyr 
            820                 825                 830         


Ala Asp Ala Ile Asn Leu Ser Arg Gly Ile Phe Asp Glu Lys Pro Thr 
        835                 840                 845             


Met Ile Pro Phe Lys Lys Pro Asn Pro Asp Glu Phe Ala Ser Trp Phe 
    850                 855                 860                 


Val Ala Ser Tyr Gln Tyr Asn Asn Tyr Gln Ser Phe Tyr Glu Leu Thr 
865                 870                 875                 880 


Pro Asp Lys Ile Glu Asn Asp Lys Lys Lys Lys Tyr Lys Asn Leu Arg 
                885                 890                 895     


Ala Ile Asn Lys Val Lys Ile Gln Asp Tyr Tyr Leu Lys Leu Met Val 
            900                 905                 910         


Asp Thr Leu Tyr Gln Asp Leu Phe Asn Gln Pro Leu Asp Lys Ser Leu 
        915                 920                 925             


Ser Asp Phe Tyr Val Ser Lys Ala Glu Arg Glu Lys Ile Lys Asn Asp 
    930                 935                 940                 


Ala Lys Ala Tyr Gln Lys Arg Asn Asp Ser Phe Leu Trp Asn Lys Val 
945                 950                 955                 960 


Ile His Leu Ser Leu Gln Asn Asn Arg Ile Thr Ala Asn Pro Lys Leu 
                965                 970                 975     


Lys Asp Ile Gly Lys Tyr Lys Arg Ala Leu Gln Asp Glu Lys Ile Ala 
            980                 985                 990         


Thr Leu Leu Thr Tyr Asp Asp Arg  Thr Trp Thr Tyr Ala  Leu Glu Lys 
        995                 1000                 1005             


Pro Glu  Lys Glu Lys Glu Asn  Asp Tyr Lys Glu Leu  His Tyr Thr 
    1010                 1015                 1020             


Ala Leu  Asn Met Glu Leu Gln  Glu Tyr Glu Lys Val  Arg Ser Lys 
    1025                 1030                 1035             


Lys Leu  Leu Lys Gln Val Gln  Gln Leu Glu Lys Gln  Ile Leu Glu 
    1040                 1045                 1050             


Glu Tyr  Thr Asp Phe Ser Ser  Thr Gln Ile His Pro  Ala Asp Phe 
    1055                 1060                 1065             


Glu Arg  Glu Gly Asn Pro Asn  Phe Lys Lys Tyr Leu  Ala His Ser 
    1070                 1075                 1080             


Ile Leu  Ala Asn Glu Asp Glu  Ile Asp Lys Leu Pro  Glu Lys Val 
    1085                 1090                 1095             


Glu Ala  Met Met Lys Leu Asp  Glu Thr Ile Thr Asn  Pro Ile Ile 
    1100                 1105                 1110             


Lys Lys  Ala Ile Val Leu Ile  Ile Ile Arg Asn Lys  Met Ala His 
    1115                 1120                 1125             


Asn Gln  Tyr Pro Pro Lys Phe  Ile Tyr Asp Leu Ala  Thr Arg Phe 
    1130                 1135                 1140             


Val Pro  Lys Lys Glu Glu Glu  Tyr Phe Ala Cys Tyr  Phe Asn Arg 
    1145                 1150                 1155             


Val Phe  Glu Thr Ile Thr Thr  Glu Leu Trp Glu Asn  Lys Lys Lys 
    1160                 1165                 1170             


Lys Asp  Lys Thr Arg Val 
    1175                 


<210>  2223
<211>  1138
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2223

Met Lys Asn Gln Ser Thr Leu Pro Ser Asn Pro Thr Asp Ile Leu Lys 
1               5                   10                  15      


Asp Lys Pro Phe Trp Ala Ala Phe Phe Asn Leu Ala Arg His Asn Val 
            20                  25                  30          


Tyr Leu Thr Val Asn His Ile Asn Lys Leu Leu Asp Leu Glu Lys Leu 
        35                  40                  45              


Tyr Asn Lys Asp Lys His Lys Glu Ile Phe Glu His Glu Asp Ile Phe 
    50                  55                  60                  


Asn Ile Ser Asp Asp Val Met Asn Asp Ala Asn Ser Asn Gly Lys Lys 
65                  70                  75                  80  


Arg Lys Leu Asp Ile Lys Lys Ile Trp Asp Asp Leu Asp Thr Asp Leu 
                85                  90                  95      


Thr Arg Lys Tyr Gln Leu Arg Glu Leu Ile Leu Lys His Phe Pro Phe 
            100                 105                 110         


Ile Gln Pro Ala Ile Ile Gly Ala Gln Thr Lys Glu Arg Thr Thr Ile 
        115                 120                 125             


Asp Lys Asp Lys Arg Ser Thr Ser Thr Ser Asn Asp Ser Leu Lys Gln 
    130                 135                 140                 


Thr Gly Glu Gly Asp Ile Asn Asp Pro Leu Ser Leu Ser Asn Val Lys 
145                 150                 155                 160 


Ser Met Phe Phe Cys Leu Leu Gln Met Leu Glu Gln Leu Arg Asn Tyr 
                165                 170                 175     


Tyr Ser His Val Lys His Ser Lys Ser Ala Thr Met Pro Asn Phe Asp 
            180                 185                 190         


Glu Asp Leu Leu Asn Trp Met Arg Tyr Ile Phe Ile Asp Ser Val Asn 
        195                 200                 205             


Lys Val Lys Glu Asp Tyr Ser Ser Asn Ser Val Ile Asp Pro Asn Thr 
    210                 215                 220                 


Ser Phe Ser His Leu Ile Ser Lys Asp Glu Gln Gly Glu Ile Lys Pro 
225                 230                 235                 240 


Cys Arg Tyr Ser Phe Thr Ser Lys Asp Gly Ser Ile Asn Ala Phe Gly 
                245                 250                 255     


Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys Gln Asp Ser Ile Trp 
            260                 265                 270         


Met Gln Lys Lys Ile Pro Gly Phe Lys Lys Ala Ser Glu Asn Tyr Met 
        275                 280                 285             


Lys Met Thr Asn Glu Val Phe Cys Arg Asn His Ile Leu Leu Pro Lys 
    290                 295                 300                 


Met Arg Leu Glu Thr Val Tyr Asp Lys Asp Trp Met Leu Leu Asp Met 
305                 310                 315                 320 


Leu Asn Glu Val Val Arg Cys Pro Leu Ser Leu Tyr Lys Arg Leu Thr 
                325                 330                 335     


Pro Ala Asn Gln Asn Lys Phe Lys Val Pro Glu Lys Ser Ser Asp Asn 
            340                 345                 350         


Ala Asn Arg Gln Glu Asp Asp Asn Pro Phe Ser Arg Ile Leu Val Arg 
        355                 360                 365             


His Gln Asn Arg Phe Pro Tyr Phe Val Leu Arg Phe Phe Asp Leu Asn 
    370                 375                 380                 


Glu Val Phe Thr Thr Leu Arg Phe Gln Ile Asn Leu Gly Cys Tyr His 
385                 390                 395                 400 


Phe Ala Ile Tyr Lys Lys Gln Ile Gly Asp Lys Lys Glu Val His His 
                405                 410                 415     


Leu Thr Arg Thr Leu Tyr Gly Phe Ser Arg Leu Gln Asn Phe Thr Gln 
            420                 425                 430         


Asn Thr Arg Pro Glu Glu Trp Asn Thr Leu Val Lys Thr Thr Glu Leu 
        435                 440                 445             


Ser Ser Gly Asn Asp Gly Lys Thr Val Gln Gly Val Pro Leu Pro Tyr 
    450                 455                 460                 


Ile Ser Tyr Thr Ile Pro His Tyr Gln Ile Glu Asn Glu Lys Ile Gly 
465                 470                 475                 480 


Ile Lys Ile Phe Gly Glu Asp Thr Ala Val Asp Thr Asp Ile Trp Pro 
                485                 490                 495     


Ser Val Ser Thr Glu Lys Gln Leu Asn Lys Pro Asp Lys Tyr Thr Leu 
            500                 505                 510         


Thr Pro Gly Phe Lys Thr Asp Ala Phe Leu Ser Val His Glu Leu Leu 
        515                 520                 525             


Pro Met Met Phe Tyr Tyr Gln Leu Leu Leu Cys Glu Gly Met Leu Lys 
    530                 535                 540                 


Thr Asp Ala Gly Asn Ala Val Glu Lys Val Leu Ile Asp Thr Arg Asn 
545                 550                 555                 560 


Ala Ile Phe Asn Leu Tyr Asp Ala Phe Val Gln Glu Lys Ile Asn Thr 
                565                 570                 575     


Ile Thr Asp Leu Glu Asn Tyr Leu Gln Asp Lys Pro Ile Leu Ile Gly 
            580                 585                 590         


His Leu Pro Lys Gln Met Ile Asp Leu Leu Lys Gly His Gln Arg Asp 
        595                 600                 605             


Met Leu Lys Glu Ala Glu Gln Lys Lys Arg Arg Leu Ile Lys Asp Thr 
    610                 615                 620                 


Glu Arg Arg Leu Lys Leu Leu Asp Lys Gln Pro Glu Gln Lys Pro Asn 
625                 630                 635                 640 


Val Ala Ala Lys Asn Thr Gly Thr Leu Leu Arg Asn Gly Gln Ile Ala 
                645                 650                 655     


Asp Trp Leu Val Lys Asp Met Met Arg Phe Gln Pro Val Lys Arg Asp 
            660                 665                 670         


Lys Glu Gly Asn Pro Ile Asn Cys Ser Lys Ala Asn Ser Thr Glu Tyr 
        675                 680                 685             


Gln Met Leu Gln Arg Ala Phe Ala Phe Tyr Ala Thr Asp Ser Cys Arg 
    690                 695                 700                 


Leu Pro Arg Tyr Phe Glu Gln Leu His Leu Ile Asn Cys Asp Asn Ser 
705                 710                 715                 720 


His Leu Phe Leu Ser Arg Phe Glu Tyr Asp Lys Gln Pro Asn Leu Ile 
                725                 730                 735     


Ala Phe Tyr Ala Ala Tyr Leu Lys Ala Lys Leu Asp Phe Leu Asn Glu 
            740                 745                 750         


Leu Arg Pro Glu Asn Trp Ala Ser Asp Asn Tyr Phe Leu Leu Leu Arg 
        755                 760                 765             


Ala Pro Lys Asn Asn Arg Gln Lys Leu Ala Glu Gly Trp Lys Asn Gly 
    770                 775                 780                 


Phe Asn Leu Pro Arg Gly Leu Phe Thr Glu Lys Ile Lys Thr Trp Phe 
785                 790                 795                 800 


Asn Glu His Lys Thr Ile Val Asp Ile Ser Asp Cys Asp Ile Phe Lys 
                805                 810                 815     


Asn Arg Val Gly Gln Val Ala Arg Leu Ile Pro Val Phe Phe Asp Lys 
            820                 825                 830         


Lys Phe Thr Asp His Ser Gln Pro Phe Tyr Arg Tyr Asn Phe Asn Val 
        835                 840                 845             


Gly Asn Val Ser Lys Ile Thr Glu Ala Asn Tyr Leu Ser Lys Glu Lys 
    850                 855                 860                 


Arg Glu Glu Leu Phe Lys Ser Tyr Gln Asn Lys Phe Lys Asn Asn Ile 
865                 870                 875                 880 


Pro Ala Lys Lys Thr Thr Glu Tyr Arg Glu Tyr Lys Asn Phe Ser Ser 
                885                 890                 895     


Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys Asn Gln Asp Ile 
            900                 905                 910         


Leu Thr Trp Leu Met Cys Lys Asn Leu Phe Asp Glu Lys Ile Lys Pro 
        915                 920                 925             


Lys Lys Asp Ile Leu Glu Pro Arg Ile Ala Val Ser Tyr Ile Lys Leu 
    930                 935                 940                 


Asp Ser Leu Gln Thr Asn Thr Ser Thr Ala Gly Ser Leu Asn Ala Leu 
945                 950                 955                 960 


Ala Lys Val Val Pro Met Thr Leu Ala Ile His Ile Asp Ser Pro Lys 
                965                 970                 975     


Pro Lys Gly Lys Ala Gly Asn Asn Glu Lys Glu Asn Lys Glu Phe Thr 
            980                 985                 990         


Val Tyr Ile Lys Glu Glu Gly Thr  Lys Leu Leu Lys Trp  Gly Asn Phe 
        995                 1000                 1005             


Lys Thr  Leu Leu Ala Asp Arg  Arg Ile Lys Gly Leu  Phe Ser Tyr 
    1010                 1015                 1020             


Ile Glu  His Asp Asp Ile Asn  Leu Glu Lys Tyr Pro  Leu Thr Lys 
    1025                 1030                 1035             


Tyr Gln  Val Asp Ser Glu Leu  Asp Leu Tyr Gln Lys  Tyr Arg Ile 
    1040                 1045                 1050             


Asp Ile  Phe Lys Gln Thr Leu  Asp Leu Glu Ala Gln  Leu Leu Asp 
    1055                 1060                 1065             


Lys Tyr  Ser Asp Leu Asn Thr  Asp Asn Phe Asn Lys  Met Leu Ser 
    1070                 1075                 1080             


Gly Trp  Ser Glu Lys Glu Gly  Ile Pro Arg Glu Ile  Lys Glu Asp 
    1085                 1090                 1095             


Thr Asp  Phe Leu Lys Asp Val  Arg Asn Ala Phe Ser  His Asn Gln 
    1100                 1105                 1110             


Tyr Pro  Val Phe Arg Val Arg  Arg Leu Met Glu Lys  Ile Glu Lys 
    1115                 1120                 1125             


Ala Phe  Phe Ile Phe Tyr Leu  Ser Met Val 
    1130                 1135             


<210>  2224
<211>  1139
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2224

Met Glu Asn Asp Lys Arg Leu Glu Glu Ser Ala Cys Tyr Thr Leu Asn 
1               5                   10                  15      


Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val 
            20                  25                  30          


Tyr Ile Thr Val Asn His Ile Asn Lys Thr Leu Glu Leu Lys Asn Lys 
        35                  40                  45              


Lys Asn Gln Glu Ile Ile Ile Asp Asn Asp Gln Asp Ile Leu Ala Ile 
    50                  55                  60                  


Lys Thr His Trp Ala Lys Val Asn Gly Asp Leu Asn Lys Thr Asp Arg 
65                  70                  75                  80  


Leu Arg Glu Leu Met Ile Lys His Phe Pro Phe Leu Glu Ala Ala Ile 
                85                  90                  95      


Tyr Ser Asn Asn Lys Glu Asp Lys Glu Glu Val Lys Glu Glu Lys Gln 
            100                 105                 110         


Ala Lys Ala Gln Ser Phe Lys Ser Leu Lys Asp Cys Leu Phe Leu Phe 
        115                 120                 125             


Leu Glu Lys Leu Gln Glu Ala Arg Asn Tyr Tyr Ser His Tyr Lys Tyr 
    130                 135                 140                 


Ser Glu Ser Ser Lys Glu Pro Glu Phe Glu Glu Gly Leu Leu Glu Lys 
145                 150                 155                 160 


Met Tyr Asn Thr Phe Asp Ala Ser Ile Arg Leu Val Lys Glu Asp Tyr 
                165                 170                 175     


Gln Tyr Asn Lys Asp Ile Asp Pro Glu Lys Asp Phe Lys His Leu Glu 
            180                 185                 190         


Arg Lys Glu Asp Phe Asn Tyr Leu Phe Thr Asp Lys Asp Asn Lys Gly 
        195                 200                 205             


Lys Ile Thr Lys Asn Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Glu 
    210                 215                 220                 


Lys Lys Asp Ala Ile Trp Met Gln Gln Lys Phe Arg Gly Phe Lys Asp 
225                 230                 235                 240 


Asn Arg Gly Asn Lys Glu Lys Met Thr His Glu Val Phe Cys Arg Ser 
                245                 250                 255     


Arg Met Leu Leu Pro Lys Ile Arg Leu Glu Ser Thr Gln Thr Gln Asp 
            260                 265                 270         


Trp Ile Leu Leu Asp Met Leu Asn Glu Leu Ile Arg Cys Pro Lys Ser 
        275                 280                 285             


Leu Tyr Glu Arg Leu Gln Gly Ala Tyr Arg Glu Lys Phe Lys Val Pro 
    290                 295                 300                 


Phe Asp Ser Ile Asp Glu Asp Tyr Asp Ala Glu Gln Glu Pro Phe Arg 
305                 310                 315                 320 


Asn Thr Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Ala Leu Arg 
                325                 330                 335     


Tyr Phe Asp Tyr Asn Glu Ile Phe Lys Asn Leu Arg Phe Gln Ile Asp 
            340                 345                 350         


Leu Gly Thr Tyr His Phe Ser Ile Tyr Lys Lys Leu Ile Gly Gly Lys 
        355                 360                 365             


Lys Glu Asp Arg His Leu Thr His Lys Leu Tyr Gly Phe Glu Arg Ile 
    370                 375                 380                 


Gln Glu Phe Thr Lys Gln Asn Arg Pro Asp Lys Trp Gln Ala Ile Ile 
385                 390                 395                 400 


Lys Asp Leu Asp Thr Tyr Glu Thr Ser Asn Glu Arg Tyr Ile Ser Glu 
                405                 410                 415     


Thr Thr Pro His Tyr His Leu Glu Asn Gln Lys Ile Gly Ile Arg Phe 
            420                 425                 430         


Arg Asn Asp Asn Asn Asp Ile Trp Pro Ser Leu Lys Thr Asn Gly Glu 
        435                 440                 445             


Lys Asn Glu Lys Ser Lys Tyr Asn Leu Asp Lys Pro Tyr Gln Ala Glu 
    450                 455                 460                 


Ala Phe Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu 
465                 470                 475                 480 


Leu Leu Lys Met Glu Asn Thr Asp Asn Asp Lys Glu Asp Asn Glu Val 
                485                 490                 495     


Gly Thr Lys Lys Lys Gly Asn Lys Asn Asn Lys Gln Glu Lys His Lys 
            500                 505                 510         


Ile Glu Glu Ile Ile Glu Asn Lys Ile Lys Asp Ile Tyr Ala Leu Tyr 
        515                 520                 525             


Asp Ala Phe Ala Asn Gly Glu Ile Asn Ser Ile Asp Glu Leu Ala Glu 
    530                 535                 540                 


Gln Arg Glu Gly Lys Asp Ile Glu Ile Gly His Leu Pro Lys Gln Leu 
545                 550                 555                 560 


Ile Val Ile Leu Lys Asn Lys Ser Lys Asp Met Ala Glu Lys Ala Asn 
                565                 570                 575     


Arg Lys Gln Lys Glu Met Ile Lys Asp Thr Lys Lys Arg Leu Ala Thr 
            580                 585                 590         


Leu Asp Lys Gln Val Lys Gly Glu Ile Glu Asp Gly Gly Arg Asn Ile 
        595                 600                 605             


Arg Leu Leu Lys Ser Gly Glu Ile Ala Arg Trp Leu Val Asn Asp Met 
    610                 615                 620                 


Met Arg Phe Gln Pro Val Gln Lys Asp Asn Glu Gly Lys Pro Leu Asn 
625                 630                 635                 640 


Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln Met Leu Gln Arg Ser Leu 
                645                 650                 655     


Ala Leu Tyr Asn Lys Glu Glu Lys Pro Thr Arg Tyr Phe Arg Gln Val 
            660                 665                 670         


Asn Leu Ile Lys Ser Ser Asn Pro His Pro Phe Leu Glu Asp Thr Lys 
        675                 680                 685             


Trp Glu Glu Cys Tyr Asn Ile Leu Ser Phe Tyr Arg Asn Tyr Leu Lys 
    690                 695                 700                 


Ala Lys Ile Lys Phe Leu Asn Lys Leu Lys Pro Glu Asp Trp Lys Lys 
705                 710                 715                 720 


Asn Gln Tyr Phe Leu Met Leu Lys Glu Pro Lys Thr Asn Arg Lys Thr 
                725                 730                 735     


Leu Val Gln Gly Trp Lys Asn Gly Phe Asn Leu Pro Arg Gly Ile Phe 
            740                 745                 750         


Thr Glu Pro Ile Lys Glu Trp Phe Lys Arg His Gln Asn Asp Ser Glu 
        755                 760                 765             


Glu Tyr Lys Lys Val Glu Ala Leu Asp Arg Val Gly Leu Val Ala Lys 
    770                 775                 780                 


Val Ile Pro Leu Phe Phe Lys Glu Glu Tyr Phe Lys Glu Asp Ala Gln 
785                 790                 795                 800 


Lys Glu Ile Asn Asn Cys Val Gln Pro Phe Tyr Ser Phe Pro Tyr Asn 
                805                 810                 815     


Val Gly Asn Ile His Lys Pro Glu Glu Lys Asn Phe Leu His Cys Glu 
            820                 825                 830         


Glu Arg Arg Lys Leu Trp Asp Lys Lys Lys Asp Lys Phe Lys Gly Tyr 
        835                 840                 845             


Lys Ala Lys Glu Lys Ser Lys Lys Met Thr Asp Lys Glu Lys Glu Glu 
    850                 855                 860                 


His Arg Ser Tyr Leu Glu Phe Gln Ser Trp Asn Lys Phe Glu Arg Glu 
865                 870                 875                 880 


Leu Arg Leu Val Arg Asn Gln Asp Ile Leu Thr Trp Leu Leu Cys Thr 
                885                 890                 895     


Lys Leu Ile Asp Lys Leu Lys Ile Asp Glu Leu Asn Ile Glu Glu Leu 
            900                 905                 910         


Gln Lys Leu Arg Leu Lys Asp Ile Asp Thr Asp Thr Ala Lys Lys Glu 
        915                 920                 925             


Lys Asn Asn Ile Leu Asn Arg Val Met Pro Met Arg Leu Pro Val Thr 
    930                 935                 940                 


Val Tyr Glu Ile Asp Lys Ser Phe Asn Ile Val Lys Asp Lys Pro Leu 
945                 950                 955                 960 


His Thr Val Tyr Ile Glu Glu Thr Gly Thr Lys Leu Leu Lys Gln Gly 
                965                 970                 975     


Asn Phe Lys Ala Leu Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser 
            980                 985                 990         


Phe Val Lys Thr Ser Ser Glu Ala  Glu Ser Lys Ser Lys  Pro Ile Ser 
        995                 1000                 1005             


Lys Leu  Arg Val Glu Tyr Glu  Leu Gly Ala Tyr Gln  Lys Ala Arg 
    1010                 1015                 1020             


Ile Asp  Ile Ile Lys Asp Met  Leu Ala Leu Glu Lys  Thr Leu Ile 
    1025                 1030                 1035             


Asp Asn  Asp Glu Asn Leu Pro  Thr Asn Lys Phe Ser  Asp Met Leu 
    1040                 1045                 1050             


Lys Ser  Trp Leu Lys Gly Lys  Gly Glu Ala Asn Lys  Ala Arg Leu 
    1055                 1060                 1065             


Gln Asn  Asp Val Gly Leu Leu  Val Ala Val Arg Asn  Ala Phe Ser 
    1070                 1075                 1080             


His Asn  Gln Tyr Pro Met Tyr  Asn Ser Glu Val Phe  Lys Gly Met 
    1085                 1090                 1095             


Lys Leu  Leu Ser Leu Ser Ser  Asp Ile Pro Glu Lys  Glu Gly Leu 
    1100                 1105                 1110             


Gly Ile  Ala Lys Gln Leu Lys  Asp Lys Ile Lys Glu  Thr Ile Glu 
    1115                 1120                 1125             


Arg Ile  Ile Glu Ile Glu Lys  Glu Ile Arg Asn 
    1130                 1135                 


<210>  2225
<211>  1124
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2225

Met Glu Asp Asn Leu Thr Lys Asn Lys Lys Lys Met Lys Ile Pro Lys 
1               5                   10                  15      


Leu Ile Glu Glu His Lys Ser Val Phe Gly Ala Tyr Leu Thr Met Ala 
            20                  25                  30          


Leu Ser Asn Val Glu Met Val Leu Asn His Ile Ala Glu Arg Ala Gly 
        35                  40                  45              


Leu Asp Lys Tyr Glu Trp Asp Glu Asp His Gly Val Glu Asp Tyr Trp 
    50                  55                  60                  


Lys Tyr Pro Val Met Gln Cys Leu Gly Arg Lys Asp Lys Pro Trp Pro 
65                  70                  75                  80  


Ile Leu Ser Asp Val Leu Leu Asp Val Arg Asn Arg Leu Phe Arg Ser 
                85                  90                  95      


Phe Pro Phe Leu Lys Ile Met Ala Glu Asn Gln Arg Asp Tyr Arg Asn 
            100                 105                 110         


Ala Lys Gly Glu Val Glu Arg Val Glu Ile Ser Glu Ser Asp Ile Phe 
        115                 120                 125             


Asp Val Leu Asn Asn Ile Phe Arg Val Leu Lys Ala Tyr Arg Asp Thr 
    130                 135                 140                 


Cys Ser His Tyr Leu Ile Glu Asn Arg Ile Trp Glu Asp Asn Ser Leu 
145                 150                 155                 160 


Met Leu Met Tyr Lys Glu Cys Pro Leu Ala Ser Met Val Asn Gln Tyr 
                165                 170                 175     


Tyr Thr Ala Ala Leu Arg Ile Thr Lys Glu Arg Tyr Gly Tyr Glu Thr 
            180                 185                 190         


Arg Asp Leu Thr Phe Ile Gln Lys Cys Arg Phe Lys Gln Glu Pro Glu 
        195                 200                 205             


Lys Asp Ala Ser Gly Lys Val Lys Lys Lys Ala Val Ser Asp Leu Asp 
    210                 215                 220                 


Phe Phe Leu Ser Leu Val Ala Leu Asn Gly Asp Ser Asn Lys Arg Leu 
225                 230                 235                 240 


His Leu Ser Gly Trp Gly Val Thr Leu Leu Ile Cys Leu Phe Leu Glu 
                245                 250                 255     


Lys Lys Tyr Val Asn Val Phe Leu Ser Lys Leu Pro Asn Pro Gly Asn 
            260                 265                 270         


Tyr Pro Pro Asn Ser Lys Glu Ser Arg Ile Ile Arg Arg Ser Met Gly 
        275                 280                 285             


Val Cys Ser Val Val Leu Pro Lys Glu Arg Ile His Ser Glu Thr Gly 
    290                 295                 300                 


Asp Leu Ser Val Ala Leu Asp Met Leu Asn Glu Leu Lys Arg Cys Pro 
305                 310                 315                 320 


Lys Glu Leu Phe Asp Thr Leu Ser Pro Gly Asp Gln Glu Arg Phe Arg 
                325                 330                 335     


Thr Ile Ser Ser Asp Tyr Asn Glu Val Leu Gln Met Arg Ser Lys Asp 
            340                 345                 350         


Arg Phe Ala Gln Leu Val Leu Gln Tyr Ile Asp His Asn Arg Leu Phe 
        355                 360                 365             


Glu Asn Leu Arg Phe His Val Asn Met Gly Lys Leu Arg Tyr Leu Phe 
    370                 375                 380                 


Asn Pro Lys Lys Tyr Cys Ile Asp Gly His Thr Arg Val Arg Val Leu 
385                 390                 395                 400 


Glu His Pro Leu Asn Gly Phe Gly Arg Leu Gln Glu Met Glu Lys Glu 
                405                 410                 415     


Arg Leu Gln Glu Asp Gly Thr Phe Ala Asp Ser Gly Ile Lys Val Arg 
            420                 425                 430         


Cys Phe Asp Glu Val Arg Arg Asp Asp Ala Asp Ser Asn Asn Tyr Pro 
        435                 440                 445             


Tyr Ile Val Asp Thr Tyr Thr His Tyr Ile Leu Glu Asn Asp Met Val 
    450                 455                 460                 


Glu Met Phe Phe Cys Ser Glu Asp Gly Trp Gly Lys Glu Met Pro Glu 
465                 470                 475                 480 


Val Thr Ser Glu Asn Gly Lys Cys Tyr Val Arg Lys Thr Val Pro His 
                485                 490                 495     


Cys Arg Met Ser Val Leu Glu Leu Pro Ala Met Leu Phe His Leu Leu 
            500                 505                 510         


Leu Cys Gly Ala Lys Asn Thr Glu Ala His Ile Gly Lys Val Cys Asp 
        515                 520                 525             


Asn Tyr Arg Arg Leu Phe Ser Asp Met Ala Gln Gly Asn Leu Thr Glu 
    530                 535                 540                 


Glu Asn Ile Leu Ser Tyr Gly Ile Lys Lys Glu Asp Ile Pro Gln Lys 
545                 550                 555                 560 


Val Trp Asp Cys Val Gln Gly Val His Thr Gly Lys Asp Cys Arg Val 
                565                 570                 575     


Phe Arg Lys Lys Glu Ile Arg Glu Arg Tyr Glu Asp Val Thr Arg Arg 
            580                 585                 590         


Leu Glu Arg Leu Met Ser Asp Arg Lys Ala Val Leu Gly Gly Glu Asn 
        595                 600                 605             


Lys Ile Gly Lys Arg Gly Phe Val Gln Ile Val Pro Gly Arg Leu Ala 
    610                 615                 620                 


Ala Tyr Leu Ala Thr Asp Ile Cys Arg Leu Gln Pro Ser Leu Arg Lys 
625                 630                 635                 640 


Gly Asp Gly Tyr Gly Thr Asp Arg Leu Thr Gly Leu Asn Phe Arg Leu 
                645                 650                 655     


Leu Gln Ser Ser Ile Ala Thr Tyr Asn Cys Gly Glu Ser Asp Ile Leu 
            660                 665                 670         


Tyr Gly Arg Phe Arg Asp Val Phe Cys Ser Ala Gly Leu Ile Asp Gly 
        675                 680                 685             


Asp Asn Pro His Pro Phe Leu Asp Lys Val Leu Pro Glu Ala Tyr Ser 
    690                 695                 700                 


Val Arg Cys Pro Arg Asn Thr Ile Glu Phe Tyr Glu Arg Tyr Leu Glu 
705                 710                 715                 720 


Glu Tyr Gln Arg Tyr Leu Lys Pro Leu Val Ile Lys Leu Glu Lys Gly 
                725                 730                 735     


Lys Val Pro Ser Leu Ser Phe Val Asn Glu Gly Gln Arg Arg Trp Ala 
            740                 745                 750         


Arg Arg Asp Asp Ala Tyr Tyr His Glu Leu Gly Asn Leu Tyr Leu Ser 
        755                 760                 765             


Gln Ala Ile Glu Leu Pro Arg Gln Met Phe Asp Ala Glu Ile Lys Asp 
    770                 775                 780                 


Lys Leu Arg Glu Met Pro Glu Met Met Asp Val Asp Phe Asp His Ala 
785                 790                 795                 800 


Asn Val Thr Phe Leu Ile Gly Glu Tyr Leu Lys Arg Val Cys His Asp 
                805                 810                 815     


Glu Ser Gln Gly Phe Tyr Ser Trp Pro Arg His Tyr Lys Tyr Val Asp 
            820                 825                 830         


Met Leu Lys Cys Ile Leu Asn Pro Lys Asn Gly Ser Leu Gln Ala Val 
        835                 840                 845             


Tyr Thr Gln Met Gly Glu Arg Glu Gly Leu Trp Gln Glu Arg Ser Gly 
    850                 855                 860                 


Leu Glu Glu Lys Tyr Ala Lys Ile Arg Leu Arg Asp Leu Ala Arg Lys 
865                 870                 875                 880 


Gly Leu Asp Lys Asp Glu Ala Asn Glu Arg Ile Lys Thr Gly Leu Gly 
                885                 890                 895     


Asn Arg Lys Lys Glu Tyr Gln Lys Ala Glu Lys Val Ile Arg Arg Tyr 
            900                 905                 910         


Lys Val Gln Asp Ala Leu Leu Phe Met Leu Ala Lys Asp Thr Leu Phe 
        915                 920                 925             


Lys Pro Val Glu Arg Phe Lys Leu Lys Asp Ile Met Pro Asp Gly Glu 
    930                 935                 940                 


Lys Gly Ile Leu Ser Glu Val Val Pro Met Asp Phe Arg Phe Met Val 
945                 950                 955                 960 


Pro Val Arg Glu Lys Gly Cys Trp Lys Val Gln Tyr Met Ser Ala Thr 
                965                 970                 975     


Leu His Ser Asp Glu Met Lys Ile Lys Asn Phe Gly Asp Phe Phe Ala 
            980                 985                 990         


Leu Ala Arg Asp Lys Arg Met Lys  Thr Leu Leu Pro Leu  Val Gly Tyr 
        995                 1000                 1005             


Glu Val  Gln Lys Lys Asp Val  Glu Asp Glu Phe Asp  Lys Tyr Asp 
    1010                 1015                 1020             


Asp Cys  Arg Pro Glu Leu Val  Ala Met Val Leu Asp  Phe Glu Arg 
    1025                 1030                 1035             


Trp Ala  Tyr Glu Thr Tyr Pro  Lys Leu Lys Glu Leu  Val Thr Asp 
    1040                 1045                 1050             


Asn Val  Asn Tyr Gly Ser Leu  Phe Ser Ala Leu Leu  Gly Gln Leu 
    1055                 1060                 1065             


Gln Asn  Met Asn Glu Leu Thr  Ser Glu Glu Lys Tyr  Ala Leu Thr 
    1070                 1075                 1080             


Gly Ile  Arg Asn Ala Phe Cys  His Asn Ser Tyr Pro  Thr Asp Ser 
    1085                 1090                 1095             


Asn Met  Val Glu Val Lys Glu  Leu Pro Lys Ile Ala  Glu Tyr Leu 
    1100                 1105                 1110             


Lys Glu  Leu Phe Lys Asp Tyr  Ile Gly Leu Glu 
    1115                 1120                 


<210>  2226
<211>  1272
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2226

Met Gly Lys Asn Asn His Tyr Gly Lys Lys Pro Asn Asp Ser Val Lys 
1               5                   10                  15      


Pro Gln Gln Lys Ala Asn Gln Asn Asn Gly Ser Asn Gln Gln Val Asn 
            20                  25                  30          


Asn Ala Pro Ser Tyr Pro Ser Leu Leu Glu Ala Pro Lys Leu Ile Ser 
        35                  40                  45              


Thr Ser Asn Asn Leu Arg Pro Ile Tyr Ala Ala Tyr Leu Asn Met Ala 
    50                  55                  60                  


Arg Gln Asn Leu Tyr Asn Val Leu Gln His Val Ser Val Leu Val Gly 
65                  70                  75                  80  


Tyr Asp Asn Lys Cys Asp Glu Glu Ala Met Lys Gln Met Lys Val Ile 
                85                  90                  95      


Asn Phe Ala Lys Glu Lys Ser Glu Lys Arg Ile Arg Ile Gln Lys Glu 
            100                 105                 110         


Leu Leu Tyr Ala Ile Pro Val Leu Arg Gln Met Leu Ser Val Asp Val 
        115                 120                 125             


Asp Glu Glu Lys Lys Thr Ile Thr Asp Glu Asp Val Gln Ser Leu Leu 
    130                 135                 140                 


Lys Asn Ile Val Ser Thr Ile Phe Asp Leu Arg Asn Phe Tyr Thr His 
145                 150                 155                 160 


Tyr Lys Pro Tyr Asn Ser Pro Glu Glu Ile Ser Phe Gln Lys Glu Thr 
                165                 170                 175     


Glu Arg Ala Leu Phe Pro Tyr Ile Asp Lys Ala Phe Asp Ser Ala Lys 
            180                 185                 190         


Arg Lys Val Glu Ala Ile Trp Asp Tyr Asn Lys Lys Asp Leu Arg Phe 
        195                 200                 205             


Tyr Glu Gly Ser Glu Arg Met Thr Val Thr Arg Lys Gly Lys Lys Lys 
    210                 215                 220                 


Ala Gln Lys Arg Val Lys Phe Phe Phe Asn Pro Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Ser Ala Leu Ser Ala Val Gly Ile Ala Phe Leu Ile Cys Lys Leu Leu 
                245                 250                 255     


Pro Lys Gln Tyr Ser Thr Gln Phe Leu Gln Gln Ile Lys Leu Phe Glu 
            260                 265                 270         


Arg Ser Pro Tyr Lys Lys Glu His Pro Ile Phe Gly Lys Ala Asn Glu 
        275                 280                 285             


Val Met Tyr Asn Met Phe Cys Ile Asp His Ile Arg Leu Pro Lys Gly 
    290                 295                 300                 


Arg Met Glu Ser Ile Ala Asp Glu Thr Ile Leu Gly Leu Asp Met Ile 
305                 310                 315                 320 


Asn Glu Leu Arg Lys Cys Pro Phe Glu Leu Phe Lys Val Leu Ser Glu 
                325                 330                 335     


Lys Asp Gln Lys Leu Phe Glu Val Glu Ala Lys Glu Asn Glu Pro Gly 
            340                 345                 350         


Glu Lys Glu Pro Ala Val Thr Gln Leu Asn Leu Met Arg Arg Tyr Lys 
        355                 360                 365             


Asp Arg Phe Ser Tyr Leu Ala Leu Arg Tyr Ile Asp Phe Gln Lys Asp 
    370                 375                 380                 


Ile Leu Pro Gly Met Ala Phe Gln Val Ala Leu Gly Thr Tyr Arg Tyr 
385                 390                 395                 400 


His Phe Tyr Asp Lys Lys Asn Cys Ile Asp Gly Gly Glu Pro Arg Val 
                405                 410                 415     


Arg Ile Trp Gln Lys Glu Ile Asn Gly Phe Gly Arg Leu Pro Gln Ile 
            420                 425                 430         


Glu Ala Glu Arg Lys Arg Lys Tyr Gly Lys Lys Glu Asp Gly Ser Lys 
        435                 440                 445             


Gly Val Phe Ile Arg Pro Phe Asp Glu Val Thr Val Asp Thr Ala Glu 
    450                 455                 460                 


Thr Glu Pro Tyr Ile Thr Asp Arg His Ala Gly Tyr Ala Ile Thr Gly 
465                 470                 475                 480 


Asn Arg Ile Gly Ile Met Trp His Asp Asp Lys His Glu Asp Phe Lys 
                485                 490                 495     


Asn Asn Gln Tyr Leu Pro Glu Leu Pro Leu Pro Ser Val Gln Thr Glu 
            500                 505                 510         


Asn Gly Glu Lys Val Gly Ala Lys Val Ser Ile Lys Asn Leu Glu Pro 
        515                 520                 525             


Ile Cys Trp Leu Ser Thr Phe Asp Leu Pro Gly Leu Ile Phe Leu His 
    530                 535                 540                 


Leu Leu Gly Gly Lys Pro Asp Thr Val Ile Lys Ser Lys Tyr Glu Ser 
545                 550                 555                 560 


Leu Lys Lys Leu Leu Asn Tyr Ile Lys Gly Asp Glu Phe Val Asp Leu 
                565                 570                 575     


Tyr Lys Asn Glu Ile Ala Ala His Ile Glu Lys Tyr Asp Ser Ala Gly 
            580                 585                 590         


Leu Ser Lys Glu Glu Glu Thr Leu Leu Arg Lys Arg Leu Lys Ala Gln 
        595                 600                 605             


Leu Glu Pro Ile Val Phe Ser Lys Phe Asn Leu His Val Asn Asp Leu 
    610                 615                 620                 


Pro Glu Met Ile Thr Asp Ile Leu Ile Gly Lys Thr Gly His Asp Glu 
625                 630                 635                 640 


Gln Thr Glu Lys Asp His Ala Glu Lys Arg Phe Asn Glu Trp Ala Arg 
                645                 650                 655     


Asn Lys Val Glu Lys Met Ile Glu Ser Leu Glu Arg Arg Ile Lys Gly 
            660                 665                 670         


Phe Glu Lys Asp Leu Glu Lys Val Gly Thr Lys Ala Asn Arg Val Gly 
        675                 680                 685             


Lys Asp Asn Phe Val Asp Ile Arg Pro Gly Ser Leu Ala Arg Tyr Leu 
    690                 695                 700                 


Ala Lys Asp Ile Met Gly Phe Gln Pro Thr Ile Ala Asp Glu Asp Lys 
705                 710                 715                 720 


Arg Gly Thr Asp Lys Leu Thr Gly Leu Asn Phe Gln Ile Met Gln Ser 
                725                 730                 735     


Ala Ile Ala Thr Phe Glu Gly Asn Ser Leu Gln Gly Thr Gln Thr Pro 
            740                 745                 750         


Leu Trp Gln Leu Phe Lys Arg Ala Asn Leu Leu Ala Lys Asp Val Asn 
        755                 760                 765             


Gly Asp Lys Asn Pro Gln Lys His Pro Phe Leu Asn Asp Val Met Ser 
    770                 775                 780                 


Ser Thr Leu Lys Asp Thr Val Asp Leu Tyr Arg Arg Tyr Gln Glu His 
785                 790                 795                 800 


Lys Leu Lys Tyr Leu Arg Lys Ile Leu Glu Glu Asn Asn Phe Lys Glu 
                805                 810                 815     


Ala Tyr Phe Leu His Gly Asn Arg Lys Arg Tyr Ala Pro Lys Thr Leu 
            820                 825                 830         


Glu Ala Val Arg Ser Leu Ala Glu Arg Tyr Leu Asn Thr Leu Tyr Leu 
        835                 840                 845             


Pro Asp Gly Leu Phe Ala Glu Glu Ile Asn Lys Val Leu Lys Asp Lys 
    850                 855                 860                 


Tyr Lys Asp Asn Lys Ser Ile Gln Glu Ala Phe Gln Asp Pro Lys Gln 
865                 870                 875                 880 


Lys Tyr Asn Ile Ala Tyr Leu Leu Asn Val Tyr Phe Glu Gln Val His 
                885                 890                 895     


Lys Asp Cys Cys Gln Pro Phe Tyr Tyr Ser Arg Asn Gly Met Phe Lys 
            900                 905                 910         


Arg Asn Tyr Glu Leu Phe Asn Thr Leu Ala Ser Ser Lys Asn Asn Lys 
        915                 920                 925             


Val Val Lys Trp Tyr Thr Val Asp Glu Met Asn Asp Leu Thr Lys Lys 
    930                 935                 940                 


Gly Ser Gln Asp Met Ser Ile Ala Lys Arg Lys Ile Glu Glu Tyr Leu 
945                 950                 955                 960 


Asp Asn Tyr Met Val Lys Asp Glu Ile Asp Asp Thr Glu Arg Leu Ala 
                965                 970                 975     


Thr Glu Glu Glu Lys Thr Arg Lys Arg Arg Phe Leu Ile Ser Leu Leu 
            980                 985                 990         


Asn Asp Cys Lys Lys Asn Glu Lys  Ile Ile Arg Arg Tyr  Lys Thr Glu 
        995                 1000                 1005             


Asp Ile  Leu Leu Phe Leu Met  Ala Lys Lys Ile Leu  Val Gly Lys 
    1010                 1015                 1020             


Leu Lys  Thr Gln Lys Gly Arg  Thr Ile Glu Gln Ser  Glu Phe Asn 
    1025                 1030                 1035             


Glu Phe  Lys Leu Ser Ala Ile  Pro Ala Phe Lys Arg  Ala Gln Lys 
    1040                 1045                 1050             


Gln Gly  Glu Glu Glu Lys Glu  Tyr Lys Glu Leu Asn  Asp Asn Arg 
    1055                 1060                 1065             


Asp Ile  Leu Ser Lys Phe Ile  Asp Phe Asn Val Glu  Ile Val Leu 
    1070                 1075                 1080             


Arg Asp  Glu Lys Gly Arg Glu  Ile Leu Asp Asp Lys  Gly Thr Pro 
    1085                 1090                 1095             


Ile Arg  Lys Lys Val Tyr Gln  Glu His Leu Gln Leu  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Asp  Phe Tyr Arg Phe Leu  Tyr Asp Thr Arg Ile  Gly Leu Leu 
    1115                 1120                 1125             


Leu Lys  Gln Leu Thr Ser Glu  Cys Ile Lys Arg Glu  Asp Ile Asp 
    1130                 1135                 1140             


Asp Glu  Leu Asp Glu Tyr Asp  Arg Asn Arg Lys Glu  Ile Phe Ala 
    1145                 1150                 1155             


Lys Ile  His Ala Ile Glu Lys  Leu Ile Ile Asn Ala  His Ala Asp 
    1160                 1165                 1170             


Gln Leu  Asp Asp Ser Asn Ala  Gly Lys Glu Gly Phe  Val Asn Glu 
    1175                 1180                 1185             


Asp Gly  Glu Pro Tyr Arg Thr  Asn Phe Arg Ser Leu  Leu Ser Leu 
    1190                 1195                 1200             


Val Glu  Ser Ile Arg Ile Asp  Arg Lys Lys Leu Thr  Lys Glu Gly 
    1205                 1210                 1215             


Glu Leu  Ile Val Glu Thr Arg  Asn Ala Phe Ser His  Asn Lys Tyr 
    1220                 1225                 1230             


Ile Glu  Gln Leu Lys Asp Ile  Ala Asp Glu Lys Gly  Leu Thr Leu 
    1235                 1240                 1245             


Pro Glu  Val Ala Lys Leu Ile  Leu Ala Asn Leu Asn  Arg Phe Ala 
    1250                 1255                 1260             


Ile Lys  Leu Gly Ile Ala Thr  Lys Lys 
    1265                 1270         


<210>  2227
<211>  1090
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2227

Met Lys Glu Glu Glu Thr Pro Val Val Ser Thr Tyr Asn Lys Asp Asn 
1               5                   10                  15      


Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val Tyr 
            20                  25                  30          


Ile Thr Ile Asn His Ile Asn Lys Ile Leu Gly Glu Ala Glu Ile Asn 
        35                  40                  45              


Ile Asp Gly Tyr Asp Ile Pro Leu Lys Asn Ile Trp Ser Gly Ile Arg 
    50                  55                  60                  


Asp Ile Asn Lys Lys Ala Arg Leu Glu Glu Leu Met Ile Lys His Phe 
65                  70                  75                  80  


Pro Phe Leu Glu Ala Met Thr His Gln Gln His Leu Thr Gly Asn Thr 
                85                  90                  95      


Lys Gln Lys Glu Glu Lys Gln Ala Glu Ile Gln Ser Phe Glu Ile Leu 
            100                 105                 110         


Lys Asp Asn Leu Phe Leu Leu Leu Lys Met Leu Gln Asp Leu Arg Asn 
        115                 120                 125             


His Tyr Ser His Tyr Lys His Ser Lys Ser Leu Glu Arg Pro Lys Phe 
    130                 135                 140                 


Asp Glu Asp Ile Arg Asn Lys Leu Tyr Asn Ile Leu Asp Thr Ser Ile 
145                 150                 155                 160 


Arg Leu Val Lys Glu Asp Tyr Lys His Asn Pro Asp Ile Lys Pro Lys 
                165                 170                 175     


Glu His Phe Lys His Leu Asp Arg Lys Arg Asn Glu Lys Phe Arg Tyr 
            180                 185                 190         


Ser Phe Ala Asp Asn Glu Gly Asn Ile Thr Ile Ser Gly Leu Leu Phe 
        195                 200                 205             


Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Val Gln Lys 
    210                 215                 220                 


Lys Leu Glu Gly Phe Arg Cys Ser Asn Glu Ser Tyr Gln Lys Met Thr 
225                 230                 235                 240 


Asn Glu Val Phe Cys Arg Asn Arg Ile Leu Leu Pro Lys Leu Arg Leu 
                245                 250                 255     


Glu Ser Thr Gln Thr Lys Asp Trp Ile Leu Leu Asp Met Leu Asn Glu 
            260                 265                 270         


Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Lys Gly Glu Asp 
        275                 280                 285             


Arg Lys Lys Phe Glu Val Pro Phe Asp Ser Thr Asp Glu Asp Tyr Asp 
    290                 295                 300                 


Ala Glu Gln Asp Pro Phe Lys Asn Thr Leu Ile Arg His Gln Asp Arg 
305                 310                 315                 320 


Phe Pro Tyr Phe Val Leu Arg Tyr Ser Asp Tyr Asn Glu Ile Phe Glu 
                325                 330                 335     


Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile Tyr 
            340                 345                 350         


Lys Lys Leu Ile Gly Gly Glu Lys Glu Asp Arg His Leu Thr His Lys 
        355                 360                 365             


Leu Tyr Gly Phe Glu Arg Leu Gln Glu Phe Ala Lys Gln Asn Arg Pro 
    370                 375                 380                 


Asp Glu Trp Lys Ala Ile Ile Lys Asp Leu Asp Thr Phe Lys Lys Gln 
385                 390                 395                 400 


Glu Asp Glu Lys Val Asn Glu Lys Pro Tyr Ile Ser Glu Thr Thr Pro 
                405                 410                 415     


His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Ala Phe Lys Asn His 
            420                 425                 430         


Asn Ile Trp Pro Ser Thr Asn Thr Glu Leu Thr Asn Asn Lys Arg Lys 
        435                 440                 445             


Lys Tyr Asn Leu Arg Thr Ser Ile Lys Ala Glu Ala Phe Leu Ser Val 
    450                 455                 460                 


His Glu Leu Leu Pro Met Met Phe Tyr Tyr Met Leu Leu Lys Thr Lys 
465                 470                 475                 480 


Asn Glu Ser Pro Arg Lys Val Glu Ala Ile Ile Glu Ser Lys Ile Lys 
                485                 490                 495     


Asp Ile Phe Thr Leu Tyr Asp Ala Phe Ala Asn Asp Glu Ile Asp Asn 
            500                 505                 510         


Thr Asp Glu Leu Glu Lys Tyr Cys Glu Asp Lys Asp Ile Lys Ile Gly 
        515                 520                 525             


His Leu Pro Lys Gln Met Ile Ala Ile Leu Tyr Asn Lys His Lys Asp 
    530                 535                 540                 


Met Val Glu Lys Ala Lys Val Lys Gln Glu Lys Met Lys Leu Ala Thr 
545                 550                 555                 560 


Glu Asn Arg Leu Lys Thr Leu Asp Lys Leu Ile Glu Gly Lys Met Lys 
                565                 570                 575     


Tyr Ala Lys Arg Gly Ile Ser Pro Leu Lys Ser Gly Glu Ile Ala Ser 
            580                 585                 590         


Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln Arg Asp Glu 
        595                 600                 605             


Asn Gly Glu Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln 
    610                 615                 620                 


Leu Leu Gln Arg Thr Leu Ala Leu Phe Gly Ser Glu His Glu Arg Leu 
625                 630                 635                 640 


Thr Pro Tyr Phe Lys Gln Met Asn Leu Ile Gly Asp Thr Asn Ser His 
                645                 650                 655     


Pro Phe Leu Lys Gln Thr Glu Trp Glu Lys Cys Asn Asn Ile Leu Ser 
            660                 665                 670         


Phe Tyr Arg Asn Tyr Leu Lys Ala Lys Ile Glu Phe Leu Asn Lys Leu 
        675                 680                 685             


Lys Pro Glu Asp Trp Lys Lys Asn Gln Cys Phe Leu Lys Leu Lys Glu 
    690                 695                 700                 


Pro Lys Thr Asn Arg Asp Thr Leu Val Gln Gly Trp Lys Asn Gly Phe 
705                 710                 715                 720 


Asn Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg Lys Trp Phe Ile 
                725                 730                 735     


Lys Tyr Trp Lys Lys Ile Lys Val Asp Asp Leu Lys Arg Val Gly Leu 
            740                 745                 750         


Val Ala Lys Val Ile Pro Leu Phe Phe Ser Glu Lys Tyr Lys Asp Ser 
        755                 760                 765             


Val Gln Pro Phe Tyr Asn Tyr Pro Phe Asn Val Gly Asn Ile Asp Lys 
    770                 775                 780                 


Pro Lys Glu Lys Asp Phe Leu Asp Ile Ala Arg Arg Arg Lys Leu Trp 
785                 790                 795                 800 


Asp Lys Lys Gln Leu Glu Phe Lys Gly Lys Thr Glu Glu Glu Lys Arg 
                805                 810                 815     


Lys Asn Pro Ser Tyr Leu Asp Phe Lys Ser Trp Lys Lys Phe Glu Arg 
            820                 825                 830         


Glu Ile Arg Leu Thr Arg Asn Gln Asp Ile Val Thr Trp Leu Met Cys 
        835                 840                 845             


Ile Glu Ile Tyr Asn Asn Gln Lys Val Glu Asn Leu Asn Thr Gly His 
    850                 855                 860                 


Ile Tyr Leu Lys Asp Ile Ile Thr Asn Val Glu Glu Glu Arg Ser Asn 
865                 870                 875                 880 


Asn Ile Leu Asn Gln Ile Lys Ser Met Gln Leu Pro Val Thr Val Tyr 
                885                 890                 895     


Glu Asn Glu Ser Ser Pro Lys Lys Lys Tyr Leu Arg Thr Ile Tyr Ile 
            900                 905                 910         


Glu Glu Asn Gly Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu 
        915                 920                 925             


Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Val Lys Thr Asn 
    930                 935                 940                 


Ser Glu Ala Glu Ser Lys Arg Asn Pro Ile Ser Lys Leu Arg Val Glu 
945                 950                 955                 960 


His Glu Leu Arg Glu Tyr Gln Lys Ala Arg Ile Glu Ile Ile Lys Asp 
                965                 970                 975     


Met Leu Ala Leu Glu Lys Thr Leu Ile Asp Asn Tyr Asp Ser Leu Asp 
            980                 985                 990         


Thr Asp Asn Phe His Asn Met Leu  Thr Gly Trp Leu Glu  Leu Lys Gly 
        995                 1000                 1005             


Glu Val  Asn Lys Ala Lys Phe  Asn Asn Asp Val Lys  Leu Leu Thr 
    1010                 1015                 1020             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1025                 1030                 1035             


Glu Asn  Leu Phe Val Asn Ile  Glu Arg Phe Ser Leu  Ser Ser Ser 
    1040                 1045                 1050             


Lys Ile  Leu Glu Ser Lys Gly  Leu Ser Ile Ala Val  Lys Leu Lys 
    1055                 1060                 1065             


Glu Glu  Val Ser Lys Ile Ile  Lys Lys Ile Gln Glu  Glu Glu Asp 
    1070                 1075                 1080             


Gly Lys  Lys Glu Lys Glu Thr  
    1085                 1090 


<210>  2228
<211>  1183
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2228

Met Pro Glu Thr Cys Arg Asn Phe Ile Ile Asn Cys Thr Glu Ile Ser 
1               5                   10                  15      


Gly Lys Leu His Arg Thr Val Leu Ile Ser Ser Arg Lys Phe His Gln 
            20                  25                  30          


Arg Arg Lys Glu Lys Lys Met Arg His Gln Gln Asn Ala Gln Tyr Gly 
        35                  40                  45              


Ala Cys Gln Trp Arg Asp Arg Ala Ser Ala Lys Lys Arg Thr Tyr Leu 
    50                  55                  60                  


Ser Gly Asp Tyr Lys Lys Asp Met Ala Met Leu Arg Ile Phe Gly Asn 
65                  70                  75                  80  


Ile Arg Asn Pro Gln Thr Arg Lys Asp Glu Phe Lys Asn Glu Val Pro 
                85                  90                  95      


Gln Phe Ile Thr Tyr Leu Thr Leu Ala Leu Gln Asn Val Ser Glu Ile 
            100                 105                 110         


Ile Gly Thr Asp Leu Ser Asn Leu Arg Asp Glu Ser Ser Val Lys Thr 
        115                 120                 125             


Ala Leu Glu Glu Asn Gly Arg Leu Phe Glu Val Ala Ser Phe Leu Trp 
    130                 135                 140                 


Met Tyr Arg Val Glu Glu Pro Gly Arg Asp Tyr Asp Arg Ile Lys Lys 
145                 150                 155                 160 


Gly Glu Tyr Ala Asp Arg Ala Lys Glu Ile Val Val Ala Leu Trp Lys 
                165                 170                 175     


Leu Arg Asn Met Phe Val His Pro Tyr Glu Arg Asn Ala Ala Arg Ala 
            180                 185                 190         


Leu Ile Val Ser Pro Glu Phe Tyr Arg Phe Ile Glu Gly Glu Leu Tyr 
        195                 200                 205             


Ser Glu Ala Arg Glu His Ala Leu Gly Pro Gly Arg Lys Ser Glu Lys 
    210                 215                 220                 


Ile Phe Lys Leu Lys Leu Phe Asn Pro His Asp Asp Ala Arg Thr Thr 
225                 230                 235                 240 


Phe Glu Phe Thr Arg Lys Gly Leu Ile Phe Leu Thr Cys Leu Gly Leu 
                245                 250                 255     


Tyr Arg His Asp Ala Ser Glu Phe Ile Gln Gln Phe Pro Asp Leu Gln 
            260                 265                 270         


Leu Pro Pro Arg Glu Trp Gln Val Glu Gln Gly Tyr Arg Ala Lys Pro 
        275                 280                 285             


Ser Glu Ser Glu Leu Val Glu Leu Arg Lys Lys Gly Gly Ala Val Lys 
    290                 295                 300                 


Ser Ile Leu Asp Ala Phe Thr Trp Tyr Ser Met Arg Ala Ser Arg Met 
305                 310                 315                 320 


Asp Ile Asp Val Ala Asn Ser Asp Tyr Leu Asn Phe Ala Asn Ile Leu 
                325                 330                 335     


Val Tyr Leu Asn Lys Val Pro Ser Ala Ala Tyr Asn Tyr Leu Leu Leu 
            340                 345                 350         


Asp Asp Glu Ala Lys Arg Leu Thr Lys Arg Ala Ala Ala Ser Gln Glu 
        355                 360                 365             


Ser Glu Glu Asn Lys Arg Phe Lys Tyr Leu Leu Gln Glu Arg Lys Lys 
    370                 375                 380                 


Asp Arg Phe Leu Thr Leu Ala Leu Ala Tyr Leu Glu Asp Phe His Lys 
385                 390                 395                 400 


Leu Asp Cys Ile Arg Phe Lys Arg Leu Asp Ile Thr Val Arg Pro Asp 
                405                 410                 415     


Arg Lys Arg Tyr Met Phe Gly Pro Ile Pro Glu Gly Thr Val Asn Glu 
            420                 425                 430         


Arg Gly Glu Pro Leu Asn Asp Ala Asn Gly Met Asp Arg His Tyr Ala 
        435                 440                 445             


Ile Gln Asn Gly Ser Ala Gln Phe Glu Phe Val Pro Glu Gln His Tyr 
    450                 455                 460                 


Gly Pro Ile Gln Ile Lys Arg Leu Arg Gly Ala Val Ser Glu Gly Glu 
465                 470                 475                 480 


Ile Met Arg Leu Leu Leu Val Met Phe Asp Asn Gly Ile Arg Arg Lys 
                485                 490                 495     


Lys Pro Asn Asp Val Ile Lys Glu Tyr Leu Ile Ala Tyr His Arg Ile 
            500                 505                 510         


Leu Glu Arg Met Leu Asn Ala Gly Asp Thr Gly Ala Phe Thr Phe Asp 
        515                 520                 525             


Asp Pro Leu Phe Arg Ala Asp Phe Lys Thr Val Ser Gly Lys Gly Asp 
    530                 535                 540                 


Asp Val Phe Thr Lys Gly Arg Phe Val Gly Glu Met Lys Pro Phe Phe 
545                 550                 555                 560 


Ser Glu Asn Val Thr Arg Tyr Phe Val Gly Asp Glu Leu Arg Pro Thr 
                565                 570                 575     


Pro Glu Ala Leu Gln Lys Lys Leu Val Lys Arg Phe Glu Ala Met Gln 
            580                 585                 590         


Gly Arg Ala Glu Asp Phe Leu Leu Lys Met Asn Arg Leu Thr Asp Trp 
        595                 600                 605             


Arg Lys Leu Asp Leu Glu Ala Arg Lys Asp Lys Ala Phe Pro Val Cys 
    610                 615                 620                 


Ser Ile Gly Glu Leu Lys Tyr Pro Pro Arg Thr Cys Lys Val Asn Asp 
625                 630                 635                 640 


Ala Gln Leu Val Lys Trp Val Leu Arg Tyr Ile Asn Leu Phe Leu Ala 
                645                 650                 655     


Lys Glu Glu Lys Phe Arg Gln Leu Pro Arg Gly Leu Arg His Arg Gly 
            660                 665                 670         


Val Arg Asp Phe Glu Phe Gln Leu Leu His Thr Asp Ile Gly Arg Phe 
        675                 680                 685             


Gly Val Asn Pro Asp Ala Leu Trp Arg Thr Leu Glu Lys Arg Ser Ser 
    690                 695                 700                 


Ile Asn Gly Glu Asp Gly Ala Leu Lys Met Leu Glu Asp Arg Glu Gln 
705                 710                 715                 720 


Glu Leu Phe Arg Ser Glu Gln Asn Arg Cys Arg Gly Lys Arg Asp Arg 
                725                 730                 735     


Asn Gly Arg Pro Leu Arg Pro Gly His Thr Leu Thr Met Leu Ala Thr 
            740                 745                 750         


Ala Ala Ala Glu Leu Tyr Arg Glu Ser Ser Glu Ser Phe Arg Ser Glu 
        755                 760                 765             


Tyr Ser Val Pro Leu Ser Asp Glu Asp Lys Asp Leu Leu Pro Tyr Val 
    770                 775                 780                 


Cys Pro Thr Tyr Gly Val Arg Ala Gly Leu Pro Leu Asp Gln Lys Ser 
785                 790                 795                 800 


Leu Val Lys Thr Val Leu Gly Ile Asp Leu Asp Thr Trp Ser Arg Ala 
                805                 810                 815     


Tyr Asp Tyr Ala Thr Gly Arg Asn Phe Glu Asn Arg Arg Leu Ser Asn 
            820                 825                 830         


Ala His Asp Leu Ile Val Ser Gln Val Pro Met Pro Asn Ala Phe Ala 
        835                 840                 845             


Ile Arg Cys Val Lys Pro Gly Glu Asn Gly Glu Pro Phe Lys Phe Asn 
    850                 855                 860                 


Pro Glu Phe Arg Thr Phe Met Pro Tyr Glu Arg Gly Lys Met Ser Leu 
865                 870                 875                 880 


Arg Gly Tyr Tyr Asp Ala Thr Pro Leu Ile Val Ala Val Lys Arg Phe 
                885                 890                 895     


Asp Glu Gln Ser Ser Leu Gly Lys Gly Gly His Glu Arg Ala Asn Ala 
            900                 905                 910         


Glu Ile Arg Cys Ser Gly Thr Glu Gly Ile Glu Thr Arg Glu Trp Thr 
        915                 920                 925             


Asp Asp Gly Asp Ile Gly Ser Gly Lys Glu Pro Pro Arg Ser Arg Pro 
    930                 935                 940                 


Ser Phe Ala Arg Gly Asp Val Asn Lys Ala Ile Gln Ala Ile Gln Leu 
945                 950                 955                 960 


Ala Glu Arg Gln Asp Lys Val Leu Leu Ala Cys Ala Lys Ala Tyr Trp 
                965                 970                 975     


Asp Arg Tyr Met Gly Glu Glu Val Thr Ala Thr Gln Asn Glu Thr Gly 
            980                 985                 990         


Lys Lys Asp Gln Gln Lys Lys Asn  Lys Ile Lys Asn Phe  His Leu Ala 
        995                 1000                 1005             


Glu Ala  Ala Asp Ile Gly Glu  Phe Phe Ser Leu Pro  Ile Asp Asp 
    1010                 1015                 1020             


Thr Val  Asn Gly Val Lys Ile  Arg Met Met Pro Asn  Asp Phe Ala 
    1025                 1030                 1035             


Arg Pro  Ala Tyr Gly Val Val  Thr Thr His Val Lys  Glu Leu Val 
    1040                 1045                 1050             


Glu Gly  Val Lys Pro Leu Pro  Gly Thr Asp Ser Val  Tyr Ser Phe 
    1055                 1060                 1065             


Tyr Asp  Leu Trp Leu Glu Leu  Arg Asn Leu Gln His  Lys Glu Asn 
    1070                 1075                 1080             


Arg Val  Arg Leu Asp Phe Leu  Pro Ala Ala Val Lys  Phe Asn Ala 
    1085                 1090                 1095             


Trp Val  Asn Ile Pro Ala Asn  Leu Glu Ser Leu Pro  Asn Asp Asp 
    1100                 1105                 1110             


Pro Glu  Lys Thr Pro Arg Ile  Leu Ser His Cys Asn  Lys Ala Leu 
    1115                 1120                 1125             


Arg Leu  Leu Arg Leu Arg Gly  Asn Val Glu Pro Leu  Ser Glu Glu 
    1130                 1135                 1140             


Glu Tyr  Leu Leu Leu Ala Lys  Phe Glu Pro Arg Leu  Arg His Pro 
    1145                 1150                 1155             


Ala Arg  Lys Gly Leu Asp Leu  Val His Phe Asp Thr  Asp Ala Val 
    1160                 1165                 1170             


Arg Ala  Ile Tyr Lys Arg Phe  Gly Phe Leu 
    1175                 1180             


<210>  2229
<211>  1124
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2229

Met Glu Asn Lys Lys Thr Leu Glu Thr Thr Pro Glu Tyr Phe Gly Ser 
1               5                   10                  15      


Tyr Leu Asn Leu Ala Arg Leu Asn Val Phe Asn Ile Ser Asn His Leu 
            20                  25                  30          


Ala Asn Lys Phe Glu Ile Val Ala Leu Asp Glu Glu Gly Asn Ile Pro 
        35                  40                  45              


Thr Ser Phe Leu Thr Asp Gly Lys Asn Lys Thr Phe Ile Ala Lys Gln 
    50                  55                  60                  


Thr His Val Phe Asp Gln Leu Lys Arg Tyr Met Pro Val Val Lys Leu 
65                  70                  75                  80  


Phe Asp Asp Glu Leu Leu Pro Lys Ser Glu Gln Glu Lys Leu Glu Asn 
                85                  90                  95      


Lys Lys Gly Lys Asp Phe Ala Lys Leu Thr Ala Thr Leu Lys Val Val 
            100                 105                 110         


Phe Lys Glu Leu Asn Leu Phe Arg Asn Asp Tyr Thr His Tyr Tyr Ser 
        115                 120                 125             


Lys Thr Asn Lys Thr Asn Arg Lys Leu Ile Ile Ser Asp Glu Leu Lys 
    130                 135                 140                 


Val Phe Leu Asn Met Ser Tyr Glu Tyr Ala Leu Leu Tyr Thr Gln Ser 
145                 150                 155                 160 


Arg Phe Lys Asp Val Phe Lys Glu Glu Asp Phe Ile Thr Ala Gln Gln 
                165                 170                 175     


Ala Gln Leu Ile Lys Asp Asp Asn Val Ile Thr Gln Asp Gly Leu Val 
            180                 185                 190         


Phe Leu Thr Thr Met Phe Leu Asp Arg Glu Asn Ala Phe Ser Phe Ile 
        195                 200                 205             


Asn Lys Ile Thr Gly Leu Lys Gly Thr Gln His Thr Ala Phe Lys Val 
    210                 215                 220                 


Lys Arg Glu Val Leu Cys Ala Tyr Cys Val Asn Leu Pro His Asp Lys 
225                 230                 235                 240 


Phe Ile Ser Glu Asp Ala Lys Gln Ser Phe Ser Leu Glu Leu Ile Asn 
                245                 250                 255     


Glu Leu Asn Lys Cys Pro Lys Thr Leu Phe Asp Val Ile Thr Asp Glu 
            260                 265                 270         


Ala Lys Lys Glu Phe Gln Pro Glu Leu Gly Asp Glu Glu Lys Glu Arg 
        275                 280                 285             


Leu Tyr Gln Asn Ser Leu Ser Pro Tyr Ala Asp Glu Lys Asn Met Asp 
    290                 295                 300                 


Ser Ile Asp Asp Tyr Glu Asn Tyr Ile Asn Asp Ile Thr Lys Arg Val 
305                 310                 315                 320 


Arg Asn Thr Asn Arg Phe Ser Tyr Phe Ala Met Lys Phe Ile Asp Gln 
                325                 330                 335     


Asn Asp Val Phe Lys Thr Ile Arg Phe Gln Leu Asp Leu Gly Lys Phe 
            340                 345                 350         


Ile Leu Asp Asp Tyr Ser Lys Ser Phe Asn Gly Val Glu Glu Pro Arg 
        355                 360                 365             


Arg Val Val Glu Arg Ala Met Ala Phe Asp Lys Leu Gln Asn Val Leu 
    370                 375                 380                 


Lys Glu Glu Asp Val Leu Lys Arg Ile Asn Thr Gly Thr Val Ser Asn 
385                 390                 395                 400 


Lys Phe Glu Gln Phe Ala Pro His Tyr Asn Phe Asp Thr Asn Lys Ile 
                405                 410                 415     


Gly Leu Lys Leu Ala Gly Ala Asp Thr Ala Lys Leu Leu Ala Gln Lys 
            420                 425                 430         


Asp Ser Ser Lys Lys Val Ile Ser Tyr Leu Gln Gln Pro Thr Ile Asp 
        435                 440                 445             


Ala Phe Leu Ser Val His Glu Leu Pro Lys Ile Ile Leu Leu Asn Tyr 
    450                 455                 460                 


Leu Gln Lys Gly Ser Ala Glu Gln Ile Ile Lys Asp Phe Ile Gln Ile 
465                 470                 475                 480 


Asn Asn Thr Lys Leu Phe Thr Lys Glu Phe Ile Glu Leu Ile Lys Ser 
                485                 490                 495     


Gln Leu Thr His Phe Asp Val Phe Asp Lys Arg Ser Gln Gly Arg Lys 
            500                 505                 510         


Gln Asp Lys Gly Ala Tyr Pro Gln Gly Lys Leu Asn His Leu Ala Ser 
        515                 520                 525             


Arg Lys Gln Lys Leu Asn Glu Leu Leu Ala Ala His His Leu Asn Asp 
    530                 535                 540                 


Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp Leu Asn Ile Glu Asp 
545                 550                 555                 560 


Val Thr Asn Lys Ile Ala Val Ser Asp Arg Ile Lys Leu Met Lys Arg 
                565                 570                 575     


Asp Cys Ile Asp Arg Leu Lys Asp Ile Lys Lys Asn Lys Thr Pro Arg 
            580                 585                 590         


Val Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile Val Asp Met Ile 
        595                 600                 605             


Ile Asp Val Asn Lys Lys Lys Lys Ile Thr Ser Phe Tyr Tyr Asp Lys 
    610                 615                 620                 


Met Gln Gln Cys Leu Ala Leu Tyr Ala Asp Thr Glu Arg Lys Thr Leu 
625                 630                 635                 640 


Phe Ile Gln Ile Ile Lys Glu Leu Glu Leu Asn Lys Ser Gly Gly His 
                645                 650                 655     


Pro Phe Leu His Lys Ile Asp Phe Glu Asn Tyr Arg Tyr Thr Ala Asp 
            660                 665                 670         


Ile Tyr Lys Ala Tyr Leu Glu Glu Lys Gly Gln Lys Leu Ile Ser Glu 
        675                 680                 685             


Val Asn Pro Lys Asn Gly Lys Lys Val Val Lys Asp Ile Ser Trp Leu 
    690                 695                 700                 


Glu Lys Asn Phe Tyr Thr Lys Glu Trp Asn Glu Glu Ile Lys Lys Gln 
705                 710                 715                 720 


Met Thr Ile Val Lys Ile Pro Asn Asp Ile Thr Lys Ile Pro Phe Thr 
                725                 730                 735     


Ile Leu Gln Phe Asp Lys Glu Lys Ser Thr Phe Asp Ile Trp Phe Glu 
            740                 745                 750         


Asn Val Thr Lys Gly Lys Ala Leu Thr Asn Asp Arg Lys Lys Pro Ile 
        755                 760                 765             


Asp Leu Pro Thr Asn Leu Phe Asp Gly Val Leu Lys Glu Leu Leu Val 
    770                 775                 780                 


Lys Glu Leu Ser Asn Lys Ser Ile Leu Phe Asp Leu Gly Ser Asn Tyr 
785                 790                 795                 800 


Asn Glu Leu Phe Lys Leu Trp Trp Glu Lys Cys Arg Glu Asp Ser Thr 
                805                 810                 815     


Gln Ser Phe Tyr Asn Ser Gly Arg Glu Tyr Thr Phe Glu Asp Phe Lys 
            820                 825                 830         


Leu Asn Phe Val Ile Asn Thr Lys Asp Lys Phe Glu His Tyr Ile Ser 
        835                 840                 845             


Asn Ser Phe Val Glu Lys Val Lys Thr Ala Lys Gln Glu Lys Gln Asn 
    850                 855                 860                 


Ile Glu Lys Gln Leu Pro His Asn Ile Gly Lys Arg Tyr Thr Ala Ile 
865                 870                 875                 880 


Asp Thr Asn Gln Val Lys Lys Ser Leu Ile Lys Lys Ile Gly Thr Thr 
                885                 890                 895     


Glu Lys Glu Ile Arg Ile Gln Gln Glu Glu Asp Arg Leu Met Leu Leu 
            900                 905                 910         


Met Phe Glu Gln Met Thr Ser Gln Thr Leu His Pro Lys Leu Lys Thr 
        915                 920                 925             


Ile Asn Ile Leu Leu Asn Glu Thr Ile Pro Ile Lys Glu Pro Ile Asn 
    930                 935                 940                 


Gly Leu Leu Ser Phe Asn Asp Leu Gly Gln Ile Ile Lys Asp Lys Lys 
945                 950                 955                 960 


Glu Lys Lys Leu Ile Val Lys Tyr Leu Val Glu Glu Arg Lys Arg Lys 
                965                 970                 975     


Asp Tyr Ser Val Leu Lys Lys Tyr Ile Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Glu Glu Asp  Glu Ile Ser Ile Glu  Ile Leu Lys 
        995                 1000                 1005             


Lys Glu  Val Glu Ser Tyr Asn  Lys Ser Arg Asp Ile  Val Phe Asp 
    1010                 1015                 1020             


Ser Ile  Phe Lys Ile Glu Gln  Ala Ile Ile Leu Lys  Asn Glu Gln 
    1025                 1030                 1035             


Glu Leu  Val Asn Ser Ser Asp  Asp Glu Asn Asn Ile  Ser His Lys 
    1040                 1045                 1050             


Thr Tyr  Leu Asn Trp Leu Leu  Leu Asn Asp Tyr Ile  Ser Gln Glu 
    1055                 1060                 1065             


Glu Tyr  Val Phe Phe Asn Met  Val Arg Asn Thr Phe  Ser His Asn 
    1070                 1075                 1080             


Gln Phe  Pro Gln Arg Lys Thr  Ile Glu Arg Tyr Met  Lys Leu Glu 
    1085                 1090                 1095             


Ser Arg  Ile Glu Ile Ala Ser  Gln Ile Ala Thr Lys  Phe Val Glu 
    1100                 1105                 1110             


Lys Val  Asn Gly Ile Ile Thr  Gln Met Gln Ser 
    1115                 1120                 


<210>  2230
<211>  1090
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2230

Met Lys Glu Glu Glu Thr Pro Val Val Ser Thr Tyr Asn Lys Asp Asn 
1               5                   10                  15      


Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val Tyr 
            20                  25                  30          


Ile Thr Ile Asn His Ile Asn Lys Ile Leu Gly Glu Ala Glu Ile Asn 
        35                  40                  45              


Ile Asp Gly Tyr Asp Ile Pro Leu Lys Asn Ile Trp Ser Gly Ile Arg 
    50                  55                  60                  


Asp Ile Asn Lys Lys Ala Arg Leu Glu Glu Leu Met Ile Lys His Phe 
65                  70                  75                  80  


Pro Phe Leu Glu Ala Met Thr His Gln Gln His Leu Thr Gly Asn Thr 
                85                  90                  95      


Lys Gln Lys Glu Glu Lys Gln Ala Glu Ile Gln Ser Phe Glu Ile Leu 
            100                 105                 110         


Lys Asp Asn Leu Phe Leu Leu Leu Lys Met Leu Gln Asp Leu Arg Asn 
        115                 120                 125             


His Tyr Ser His Tyr Lys His Ser Lys Ser Leu Glu Arg Pro Lys Phe 
    130                 135                 140                 


Asp Glu Asp Ile Arg Asn Lys Leu Tyr Asn Ile Leu Asp Thr Ser Ile 
145                 150                 155                 160 


Arg Leu Val Lys Glu Asp Tyr Lys His Asn Pro Asp Ile Lys Pro Lys 
                165                 170                 175     


Glu His Phe Lys His Leu Asp Arg Lys Arg Asn Glu Lys Phe Arg Tyr 
            180                 185                 190         


Ser Phe Ala Asp Asn Glu Gly Asn Ile Thr Ile Ser Gly Leu Leu Phe 
        195                 200                 205             


Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Val Gln Lys 
    210                 215                 220                 


Lys Leu Glu Gly Phe Arg Cys Ser Asn Glu Ser Tyr Gln Lys Met Thr 
225                 230                 235                 240 


Asn Glu Val Phe Cys Arg Asn Arg Ile Leu Leu Pro Lys Leu Arg Leu 
                245                 250                 255     


Glu Ser Thr Gln Thr Lys Asp Trp Ile Leu Leu Asp Met Leu Asn Glu 
            260                 265                 270         


Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Lys Gly Glu Asp 
        275                 280                 285             


Arg Lys Lys Phe Glu Val Pro Phe Asp Ser Thr Asp Glu Asp Tyr Asp 
    290                 295                 300                 


Ala Glu Gln Asp Pro Phe Lys Asn Thr Leu Ile Arg His Gln Asp Arg 
305                 310                 315                 320 


Phe Pro Tyr Phe Val Leu Arg Tyr Ser Asp Tyr Asn Glu Ile Phe Glu 
                325                 330                 335     


Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile Tyr 
            340                 345                 350         


Lys Lys Leu Ile Gly Gly Glu Lys Glu Asp Arg His Leu Thr His Lys 
        355                 360                 365             


Leu Tyr Gly Phe Glu Arg Leu Gln Glu Phe Ala Lys Gln Asn Arg Pro 
    370                 375                 380                 


Asp Glu Trp Lys Ala Ile Ile Lys Asp Leu Asp Thr Phe Lys Lys Gln 
385                 390                 395                 400 


Glu Asp Glu Lys Val Asn Glu Lys Pro Tyr Ile Ser Glu Thr Thr Pro 
                405                 410                 415     


His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Ala Phe Lys Asn His 
            420                 425                 430         


Asn Ile Trp Pro Ser Thr Asn Thr Glu Leu Thr Asn Asn Lys Arg Lys 
        435                 440                 445             


Lys Tyr Asn Leu Arg Thr Ser Ile Lys Ala Glu Ala Phe Leu Ser Val 
    450                 455                 460                 


His Glu Leu Leu Pro Met Met Phe Tyr Tyr Met Leu Leu Lys Thr Lys 
465                 470                 475                 480 


Asn Glu Ser Pro Arg Lys Val Glu Ala Ile Ile Glu Ser Lys Ile Lys 
                485                 490                 495     


Asp Ile Phe Thr Leu Tyr Asp Ala Phe Ala Asn Asp Glu Ile Asp Asn 
            500                 505                 510         


Thr Asp Glu Leu Glu Lys Tyr Cys Glu Asp Lys Asp Ile Lys Ile Gly 
        515                 520                 525             


His Leu Pro Lys Gln Met Ile Ala Ile Leu Tyr Asn Lys His Lys Asp 
    530                 535                 540                 


Met Val Glu Lys Ala Lys Val Lys Gln Glu Lys Met Lys Leu Ala Thr 
545                 550                 555                 560 


Glu Asn Arg Leu Lys Thr Leu Asp Lys Leu Ile Glu Gly Lys Met Lys 
                565                 570                 575     


Tyr Ala Lys Arg Gly Ile Ser Pro Leu Lys Ser Gly Glu Ile Ala Ser 
            580                 585                 590         


Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln Arg Asp Glu 
        595                 600                 605             


Asn Gly Glu Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln 
    610                 615                 620                 


Leu Leu Gln Arg Thr Leu Ala Leu Phe Gly Ser Glu His Glu Arg Leu 
625                 630                 635                 640 


Thr Pro Tyr Phe Lys Gln Met Asn Leu Ile Gly Asp Thr Asn Ser His 
                645                 650                 655     


Pro Phe Leu Lys Gln Thr Glu Trp Glu Lys Cys Asn Asn Ile Leu Ser 
            660                 665                 670         


Phe Tyr Arg Asn Tyr Leu Lys Ala Lys Ile Glu Phe Leu Asn Lys Leu 
        675                 680                 685             


Lys Pro Glu Asp Trp Lys Lys Asn Gln Cys Phe Leu Lys Leu Lys Glu 
    690                 695                 700                 


Pro Lys Thr Asn Arg Asp Thr Leu Val Gln Gly Trp Lys Asn Gly Phe 
705                 710                 715                 720 


Asn Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg Lys Trp Phe Ile 
                725                 730                 735     


Lys Tyr Trp Lys Lys Ile Lys Val Asp Asp Leu Lys Arg Val Gly Leu 
            740                 745                 750         


Val Ala Lys Val Ile Pro Leu Phe Phe Ser Glu Lys Tyr Lys Asp Ser 
        755                 760                 765             


Val Gln Pro Phe Tyr Asn Tyr Pro Phe Asn Val Gly Asn Ile Asp Lys 
    770                 775                 780                 


Pro Lys Glu Lys Asp Phe Leu Asp Ile Ala Arg Arg Arg Lys Leu Trp 
785                 790                 795                 800 


Asp Lys Lys Gln Leu Glu Phe Lys Gly Lys Thr Glu Glu Glu Lys Arg 
                805                 810                 815     


Lys Asn Pro Ser Tyr Leu Asp Phe Lys Ser Trp Lys Lys Phe Glu Arg 
            820                 825                 830         


Glu Ile Arg Leu Thr Arg Asn Gln Asp Ile Val Thr Trp Leu Met Cys 
        835                 840                 845             


Ile Glu Ile Tyr Asn Asn Gln Lys Val Glu Asn Leu Asn Thr Gly His 
    850                 855                 860                 


Ile Tyr Leu Lys Asp Ile Ile Thr Asn Val Glu Glu Glu Arg Ser Asn 
865                 870                 875                 880 


Asn Ile Leu Asn Gln Ile Lys Ser Met Gln Leu Pro Val Thr Val Tyr 
                885                 890                 895     


Glu Asn Glu Ser Ser Pro Lys Lys Lys Tyr Leu Arg Thr Ile Tyr Ile 
            900                 905                 910         


Glu Glu Asn Gly Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu 
        915                 920                 925             


Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Val Lys Thr Asn 
    930                 935                 940                 


Ser Glu Ala Glu Ser Lys Arg Asn Pro Ile Ser Lys Leu Arg Val Glu 
945                 950                 955                 960 


His Glu Leu Arg Glu Tyr Gln Lys Ala Arg Ile Glu Ile Ile Lys Asp 
                965                 970                 975     


Met Leu Ala Leu Glu Lys Thr Leu Ile Asp Asn Tyr Asp Ser Leu Asp 
            980                 985                 990         


Thr Asp Asn Phe His Asn Met Leu  Thr Gly Trp Leu Glu  Leu Lys Gly 
        995                 1000                 1005             


Glu Val  Asn Lys Ala Lys Phe  Asn Asn Asp Val Lys  Leu Leu Thr 
    1010                 1015                 1020             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1025                 1030                 1035             


Glu Asn  Leu Phe Val Asn Ile  Glu Arg Phe Ser Leu  Ser Ser Ser 
    1040                 1045                 1050             


Lys Ile  Leu Glu Ser Lys Gly  Leu Ser Ile Ala Val  Lys Leu Lys 
    1055                 1060                 1065             


Glu Glu  Val Ser Lys Ile Ile  Lys Lys Ile Gln Glu  Glu Glu Asp 
    1070                 1075                 1080             


Gly Lys  Lys Glu Lys Glu Thr  
    1085                 1090 


<210>  2231
<211>  1182
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2231

Met Lys Asp Lys Ser Phe Ser Thr Thr Ser Ser Ala Ile Asn Glu Thr 
1               5                   10                  15      


Ile Thr Thr Asp Asn Leu Lys Tyr Pro Glu Arg Leu Asn Leu Ile Leu 
            20                  25                  30          


Ser Lys Arg Leu Arg Pro Lys Asn Glu Leu Gln Pro Leu Trp Ala Ala 
        35                  40                  45              


Tyr Phe Asn Met Ala Arg Tyr Asn Met Tyr Thr Thr Leu Val His Ile 
    50                  55                  60                  


Ala Thr Ala Thr Gly Leu Ser Asp Glu Glu Asn Met Glu Asn Arg Met 
65                  70                  75                  80  


Asp Lys Met Arg Ile Leu Asn Glu Pro Val Glu Pro Glu Ile Glu His 
                85                  90                  95      


Ser Leu Arg Lys Leu Leu Cys Arg His Phe Pro Phe Ala Val Trp Met 
            100                 105                 110         


Lys Asp Ser Lys Glu Asp Ser Ala Asp Glu Asp Tyr Arg Val Ile Ser 
        115                 120                 125             


Val Lys Glu Leu Arg Asp Cys Leu Lys Thr Val Ser Tyr Thr Leu Asn 
    130                 135                 140                 


Tyr Phe Arg Asn Tyr Tyr Ser His Thr Arg His Val Glu Thr Arg Ser 
145                 150                 155                 160 


Glu Asp Ile Ile Ala Ala Ser Arg Asn Ser Glu Lys Gln Thr Gly Ile 
                165                 170                 175     


Phe Leu Asn Lys Val Cys Thr Val Ala Thr Arg Arg Val Lys Ser Arg 
            180                 185                 190         


Phe Ser Asp Lys Ser Asn Lys Gly Gln Ala Gly Met Ile Asp Asp Gln 
        195                 200                 205             


Ser Met Lys Phe Ile Thr Glu Gly Lys Val Lys Phe Arg Asn Asn Asn 
    210                 215                 220                 


Gly Ile Lys Gly Thr Ile Tyr Asn Pro Asp His Phe Leu Tyr Pro Leu 
225                 230                 235                 240 


Phe Leu Asp Arg Ser Ser Ala Leu Arg Asp Gly Thr Asn Pro Glu Arg 
                245                 250                 255     


Leu Ser Thr Val Gly Lys Ile Gln Leu Ile Cys Leu Leu Leu Asp Lys 
            260                 265                 270         


Lys Tyr Ile Thr Glu Phe Leu Asp Gln Ala Gly Phe Leu Ser Ala Phe 
        275                 280                 285             


Asn Asn Asp Ala Pro Ala Pro Arg Leu Ser Glu Arg Arg Leu Ile Leu 
    290                 295                 300                 


Glu Val Leu Ser Asp Leu Arg Ile Arg Leu Pro Gln Arg Lys Ile Asp 
305                 310                 315                 320 


Ala Thr Cys Asn Asp Ile Gln Val Ala Leu Asp Met Leu Asn Glu Leu 
                325                 330                 335     


Lys Lys Cys Pro Lys Glu Leu Phe Glu Leu Leu Glu Ala Lys Asp Lys 
            340                 345                 350         


Ala Thr Phe Ser Ile Leu Ser Ser Thr Gly Glu His Ile Leu Leu Arg 
        355                 360                 365             


Arg Ser Ser Asp Arg Phe Thr Gln Leu Ala Leu Gln Trp Phe Asp Val 
    370                 375                 380                 


Asn Lys Ala Phe Ser Arg Ile Arg Phe Gln Met Asn Ala Gly Ile Phe 
385                 390                 395                 400 


Arg Tyr Leu Phe Asn Asp Ser Lys Thr Cys Ile Asp Gly Lys Thr Arg 
                405                 410                 415     


Leu Arg Val Leu Gln Glu Pro Leu Asn Cys Phe Gly Arg Ile Gln Glu 
            420                 425                 430         


Val Glu Asp Ser Arg Glu Ser Asn Arg Tyr Gly Asn Asp Gly Pro Trp 
        435                 440                 445             


Arg Arg Phe Glu Ile Lys Gly Phe Asp Glu Ala Ala Arg Asn Asp Val 
    450                 455                 460                 


Asn Cys Leu Pro Tyr Ile Asn Asp Ser Arg Thr Arg Tyr Leu Ile Thr 
465                 470                 475                 480 


Glu Asp Asn Ile Gly Ile Arg Phe Ser Gly Asp Asp Glu Ala Cys Gly 
                485                 490                 495     


Asn Tyr Phe Pro Arg Ile Asp Glu Lys Asn Gly Lys Tyr Lys Val Thr 
            500                 505                 510         


Cys Leu Pro Ala Gln Cys Met Ile Ser Ile Tyr Glu Leu Gln Ala Met 
        515                 520                 525             


Leu Phe Leu His Leu Leu Asn Pro Gly Asn Asp Gly Gly Ile Ala Pro 
    530                 535                 540                 


Val Glu Lys Ile Ile Ile Asp Lys Val Glu Ser Tyr Arg Arg Phe Phe 
545                 550                 555                 560 


Ser Asp Ile Lys Asn Gly Leu Leu Thr Pro Ser Gly Leu Thr Glu Ser 
                565                 570                 575     


Ser Leu Asn Asp Lys Leu Thr Ser Thr Tyr Gly Ile Ser Leu Ser Asp 
            580                 585                 590         


Ile Pro Asp Lys Met Lys Asp Tyr Leu Leu Lys Lys Asn Asn Lys Gly 
        595                 600                 605             


Arg Gly Phe Asn Ala Tyr Arg Asp Arg Leu Ile Glu Thr Leu Lys Glu 
    610                 615                 620                 


Glu Thr Glu Tyr Arg Ile Lys Arg Leu Glu Glu Asn Leu Lys Ala Thr 
625                 630                 635                 640 


Asn Ser Asp Thr Asn Lys Pro Gly Lys Pro Gly Tyr Val Gln Ile Lys 
                645                 650                 655     


Pro Gly Ser Leu Ala Ser Phe Ile Ser Lys Asp Ile Val Phe Phe Gln 
            660                 665                 670         


Glu Cys Asn Ala Asp Gln Lys Met Thr Gly Leu Asn Phe Ser Val Met 
        675                 680                 685             


Gln Gly Leu Ile Ala Thr Phe Gly Ser Gln Glu Gly Ala Thr Ala Asp 
    690                 695                 700                 


Asp Leu Arg Met Ala Phe Cys Lys Ser Gly Leu Ile Ala Ala Asn Gly 
705                 710                 715                 720 


Ser Cys Gly Thr His Pro Phe Leu Ala Ile Ala Phe Asn Ala Gly Val 
                725                 730                 735     


Lys Asn Thr Leu Asp Leu Tyr Lys Lys Tyr Leu Asn Ala Arg Lys Ser 
            740                 745                 750         


Tyr Leu Ser Gly Ile Ile Pro Asp Asn Ala Pro Phe Leu His Ala Asp 
        755                 760                 765             


Arg Ile Arg Trp Ala Val Asn Asp Asp Ala Tyr Tyr Lys Asp Tyr Ala 
    770                 775                 780                 


Glu Arg Cys Leu Gln Arg Pro Val Ile Leu Pro Arg Arg Leu Phe Glu 
785                 790                 795                 800 


Thr Ser Ile Arg Glu Asn Leu Leu Ala Leu Asn Asp Glu Asn Ala Asn 
                805                 810                 815     


Ala Leu Lys Lys Val Ile Ile Asp Ala Gly Asn His Cys Asn Ser Ala 
            820                 825                 830         


Phe Met Ile Asp Ser Tyr Phe Tyr Tyr Val Lys Asn Asp Ser Pro Gln 
        835                 840                 845             


Val Phe His Gly Ala Cys Glu Gly Asp Met Ile His Thr Tyr Gly His 
    850                 855                 860                 


Arg Phe Phe Gln Val Val Arg Arg Asn Leu Lys Asn Ala Glu Ala Ile 
865                 870                 875                 880 


Leu Ser Lys Leu Lys Lys Asp Ser Asn Thr His Asn Thr Tyr Ile Gly 
                885                 890                 895     


Ala Leu Ser Asp Ala Ile Cys Trp Ala Lys Glu Asn Pro Ile Lys Pro 
            900                 905                 910         


Thr Phe Ser Val Gly Arg Ser Arg Leu Asn Asn His Ser Glu Asn Glu 
        915                 920                 925             


Ile Ala Ala Met Ile Lys Arg Ala Phe Asn Glu Tyr Met Ala Thr Glu 
    930                 935                 940                 


Lys Thr Leu Arg Arg Tyr Val Ile Gln Asp Glu Leu Leu Phe Leu Ala 
945                 950                 955                 960 


Ala Met Lys Thr Ile Lys Ser Lys Leu Gly Val Pro Asp Gly Glu Trp 
                965                 970                 975     


Lys Leu Gly Ser Ile Gly Ser Lys Ser Gly Ser Ile Leu Asp Lys Glu 
            980                 985                 990         


Leu Pro Leu Ile Gln Thr Pro Ala  Lys Phe Asn Ile Lys  Lys Arg Pro 
        995                 1000                 1005             


Tyr Thr  Asn Asp Ile Ile Glu  Lys Asp Leu Val Glu  Phe Val Ile 
    1010                 1015                 1020             


Glu Gln  His Asn Val Ser Ile  Lys Asp Tyr Gly Glu  Ile Tyr Arg 
    1025                 1030                 1035             


Ile Leu  Ala Asp Glu Arg Leu  Tyr Gly Leu Leu Lys  Tyr His Lys 
    1040                 1045                 1050             


Asn Glu  Thr Val Phe Ala Ser  Asp Leu Lys Asn Glu  Ile Glu Lys 
    1055                 1060                 1065             


Tyr Asp  Glu Lys Arg Val Lys  Val Phe Glu Asp Ile  Met Asn Tyr 
    1070                 1075                 1080             


Glu Lys  Lys Ile Thr Asn Gly  Val Thr Asp Arg Gln  Leu Cys Glu 
    1085                 1090                 1095             


Ser Met  Asp Lys Glu His Ala  Lys Asp Ile Asp Phe  Lys Val Met 
    1100                 1105                 1110             


Gln Thr  Phe Asp Thr Met Asn  Asp Lys Leu Thr Lys  Met Glu Leu 
    1115                 1120                 1125             


Arg Arg  Ile Arg Asn Ala Phe  Cys His Asn Ser Tyr  Pro Asp Val 
    1130                 1135                 1140             


Asn Ala  Phe Asp Lys Ser Ser  Gly Thr Thr Lys Arg  Ile His Asn 
    1145                 1150                 1155             


Ala Asp  Ile Pro Gly Thr Ala  Glu Lys Ile Ser Gly  Ile Val Asn 
    1160                 1165                 1170             


Asp Ile  Ser Ser Lys Thr Lys  Ala Lys 
    1175                 1180         


<210>  2232
<211>  1090
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2232

Met Asn Ile Pro Ala Leu Val Glu Asn Gln Lys Lys Tyr Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Val Met Ala Met Leu Asn Ala Gln Thr Val Leu Asp His Ile 
            20                  25                  30          


Gln Lys Val Ala Asp Ile Glu Gly Glu Gln Asn Glu Asn Asn Glu Asn 
        35                  40                  45              


Leu Trp Phe His Pro Val Met Ser His Leu Tyr Asn Val Lys Asn Gly 
    50                  55                  60                  


Tyr Asp Lys Gln Pro Glu Lys Thr Met Phe Ile Ile Glu Arg Leu Gln 
65                  70                  75                  80  


Ser Tyr Phe Pro Phe Leu Lys Ile Met Ala Glu Asn Gln Arg Glu Tyr 
                85                  90                  95      


Ser Asn Gly Lys Tyr Lys Gln Asn Arg Val Glu Val Asn Ser Asn Asp 
            100                 105                 110         


Ile Phe Glu Val Leu Lys Arg Ala Phe Gly Val Leu Lys Met Tyr Arg 
        115                 120                 125             


Asp Leu Thr Asn His Tyr Lys Thr Tyr Glu Glu Lys Leu Asn Asp Gly 
    130                 135                 140                 


Cys Glu Phe Leu Thr Ser Thr Glu Gln Pro Leu Ser Gly Met Ile Asn 
145                 150                 155                 160 


Asn Tyr Tyr Thr Val Ala Leu Arg Asn Met Asn Glu Arg Tyr Gly Tyr 
                165                 170                 175     


Lys Thr Glu Asp Leu Ala Phe Ile Gln Asp Lys Arg Phe Lys Phe Val 
            180                 185                 190         


Lys Asp Ala Tyr Gly Lys Lys Lys Ser Gln Val Asn Thr Gly Phe Phe 
        195                 200                 205             


Leu Ser Leu Gln Asp Tyr Asn Gly Asp Thr Gln Lys Lys Leu His Leu 
    210                 215                 220                 


Ser Gly Val Gly Ile Ala Leu Leu Ile Cys Leu Phe Leu Asp Lys Gln 
225                 230                 235                 240 


Tyr Ile Asn Ile Phe Leu Thr Lys Leu Pro Ile Phe Ser Ser Tyr Asn 
                245                 250                 255     


Ala Gln Ser Glu Glu Arg Arg Ile Ile Ile Arg Ser Phe Gly Ile Asn 
            260                 265                 270         


Ser Ile Lys Leu Pro Lys Asp Arg Ile His Ser Glu Lys Ser Asn Lys 
        275                 280                 285             


Ser Val Ala Met Asp Met Leu Asn Glu Val Lys Arg Cys Pro Asp Glu 
    290                 295                 300                 


Leu Phe Thr Thr Leu Ser Ala Glu Lys Gln Ser Arg Phe Arg Ile Ile 
305                 310                 315                 320 


Ser Asn Asp His Asn Glu Val Leu Met Lys Arg Ser Ser Asp Arg Phe 
                325                 330                 335     


Val Pro Leu Leu Leu Gln Tyr Ile Asp Tyr Gly Lys Leu Phe Asp His 
            340                 345                 350         


Ile Arg Phe His Val Asn Met Gly Lys Leu Arg Tyr Leu Leu Lys Ala 
        355                 360                 365             


Asp Lys Thr Cys Ile Asp Gly Gln Thr Arg Val Arg Val Ile Glu Gln 
    370                 375                 380                 


Pro Leu Asn Gly Phe Gly Arg Leu Glu Glu Ala Glu Thr Met Arg Lys 
385                 390                 395                 400 


Gln Glu Asn Gly Thr Phe Gly Asn Ser Gly Ile Arg Ile Arg Asp Phe 
                405                 410                 415     


Glu Asn Val Lys Arg Asp Asp Ala Asn Pro Ala Asn Tyr Pro Tyr Ile 
            420                 425                 430         


Val Asp Thr Tyr Thr His Tyr Ile Leu Glu Asn Asn Lys Val Glu Met 
        435                 440                 445             


Phe Ile Ser Asp Glu Glu Asn Ser Thr Pro Leu Leu Pro Val Ile Glu 
    450                 455                 460                 


Asp Asp Arg Tyr Val Val Lys Thr Ile Pro Ser Cys Arg Met Ser Thr 
465                 470                 475                 480 


Leu Glu Ile Pro Ala Met Ala Phe His Met Phe Leu Phe Gly Ser Gly 
                485                 490                 495     


Lys Thr Glu Lys Leu Ile Val Asp Val His Asn Arg Tyr Lys Arg Leu 
            500                 505                 510         


Phe Lys Ala Met Gln Lys Glu Glu Val Thr Val Gln Asn Ile Ala Ser 
        515                 520                 525             


Phe Gly Ile Ala Glu Ser Asp Leu Pro Gln Lys Ile Ile Asp Leu Ile 
    530                 535                 540                 


Ser Gly Asn Ala His Gly Lys Asp Val Asp Ala Phe Ile Arg Leu Thr 
545                 550                 555                 560 


Val Asp Asp Met Leu Ala Asp Thr Glu Arg Arg Ile Lys Arg Phe Lys 
                565                 570                 575     


Asp Asp Arg Lys Ser Ile Arg Ser Ala Asp Asn Lys Met Gly Lys Arg 
            580                 585                 590         


Gly Phe Lys Gln Ile Ser Thr Gly Lys Leu Ala Asp Phe Leu Ala Lys 
        595                 600                 605             


Asp Ile Val Leu Phe Gln Pro Ser Val Asn Asp Gly Glu Asn Lys Ile 
    610                 615                 620                 


Thr Gly Leu Asn Tyr Arg Ile Met Gln Ser Ala Ile Ala Val Tyr Asp 
625                 630                 635                 640 


Ser Gly Asp Asp Tyr Glu Ala Lys Gln Gln Phe Lys Leu Met Phe Glu 
                645                 650                 655     


Lys Ala Arg Leu Ile Gly Lys Gly Thr Thr Lys Pro His Pro Phe Leu 
            660                 665                 670         


Tyr Lys Val Phe Ala Arg Ala Ile Pro Ala Asn Ala Val Glu Phe Tyr 
        675                 680                 685             


Glu Arg Tyr Leu Ile Glu Arg Lys Phe Tyr Leu Thr Gly Leu His Lys 
    690                 695                 700                 


Glu Ile Lys Asn Gly Asn Arg Val Asp Val Pro Phe Ile Arg Arg Asp 
705                 710                 715                 720 


Gln Asn Lys Trp Lys Thr Pro Ala Met Lys Thr Leu Gly Arg Ile Tyr 
                725                 730                 735     


Asp Glu Asp Leu Pro Val Glu Leu Pro Arg Gln Met Phe Asp Asn Glu 
            740                 745                 750         


Ile Lys Ser His Leu Lys Ser Leu Pro Gln Met Glu Gly Ile Asp Phe 
        755                 760                 765             


Asn Asn Ala Asn Ile Thr Tyr Leu Ile Ala Glu Tyr Met Lys Arg Val 
    770                 775                 780                 


Leu Asp Asp Asp Phe Gln Thr Phe Tyr Gln Trp Lys Arg Asn Tyr Arg 
785                 790                 795                 800 


Tyr Met Asp Leu Leu Lys Gly Glu Tyr Asp Arg Lys Gly Ser Leu Gln 
                805                 810                 815     


Asn Cys Phe Thr Ser Val Glu Glu Arg Glu Cys Leu Trp Lys Glu Arg 
            820                 825                 830         


Glu Thr Arg Thr Glu Gln Tyr Arg Lys Gln Ala Ser Asn Lys Ile Arg 
        835                 840                 845             


Ser Asn Arg Gln Met Arg Asn Ala Ser Ser Glu Glu Ile Glu Thr Ile 
    850                 855                 860                 


Leu Asp Lys Arg Leu Ser Asn Ser Arg Asn Glu Tyr Gln Lys Ser Glu 
865                 870                 875                 880 


Lys Val Ile Arg Arg Tyr Lys Ile Gln Asp Ala Leu Leu Phe Leu Leu 
                885                 890                 895     


Ala Lys Lys Thr Leu Thr Glu Leu Ala Asp Phe Asp Gly Glu Arg Phe 
            900                 905                 910         


Lys Leu Lys Glu Ile Met Pro Asp Ala Glu Lys Gly Ile Leu Ser Glu 
        915                 920                 925             


Ile Met Pro Met Ser Phe Thr Phe Glu Lys Gly Gly Lys Lys Tyr Thr 
    930                 935                 940                 


Ile Thr Ser Glu Gly Met Lys Leu Lys Asn Tyr Gly Asp Phe Phe Val 
945                 950                 955                 960 


Leu Ala Ser Asp Lys Arg Ile Gly Asn Leu Leu Glu Leu Val Gly Ser 
                965                 970                 975     


Asn Thr Val Ser Lys Glu Asp Ile Met Glu Glu Phe Lys Lys Tyr Asp 
            980                 985                 990         


Gln Cys Arg Pro Glu Ile Ser Ser  Ile Val Phe Asn Leu  Glu Lys Trp 
        995                 1000                 1005             


Ala Phe  Asp Thr Tyr Pro Glu  Leu Ser Ala Arg Val  Asp Arg Lys 
    1010                 1015                 1020             


Glu Lys  Val Asp Phe Trp Ser  Ile Leu Asp Val Leu  Ser Asn Asn 
    1025                 1030                 1035             


Lys Asp  Ile Asn Asn Glu Gln  Ser Tyr Ile Leu Arg  Lys Ile Arg 
    1040                 1045                 1050             


Asn Ala  Phe Asp His Asn Asn  Tyr Pro Asp Lys Gly  Ile Val Glu 
    1055                 1060                 1065             


Ile Arg  Ala Leu Pro Glu Ile  Ala Met Ser Ile Lys  Lys Ala Phe 
    1070                 1075                 1080             


Gly Glu  Tyr Ala Ile Met Lys  
    1085                 1090 


<210>  2233
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2233

Met Asn Thr His Gln Glu Glu Leu Gln Ser Trp Ile Thr Arg Lys Arg 
1               5                   10                  15      


Leu Pro Asp Thr Glu Met Lys Lys Tyr Trp Ala Ala Tyr Met Asn Leu 
            20                  25                  30          


Ala Arg Leu Asn Phe Phe Lys Thr Leu Met Phe Ile Ser Asn Ser Ile 
        35                  40                  45              


Gly Asp Leu Lys Pro Ala Lys Asp Asn Asn Gly Lys Gly Asn Thr Glu 
    50                  55                  60                  


Val Asn Met His Asn Met Gly Ile Leu Thr Ala Leu Leu Gly Pro Glu 
65                  70                  75                  80  


Asp Glu Glu Lys Ala Arg Leu Leu Ile Phe Lys His Phe Pro Phe Leu 
                85                  90                  95      


Arg Thr Phe Cys Ile Glu Lys Glu Leu Ser Leu Ser Lys Gln Arg Thr 
            100                 105                 110         


Ile Leu Ile Asp Met Ala Cys Ile Ile Gly Arg Tyr Arg Asn Met Tyr 
        115                 120                 125             


Ser His Ser Ile Phe Ile Ser Asp Asp Asn Glu Lys Val Leu Glu Ser 
    130                 135                 140                 


Glu Lys Arg Cys Ser Glu Tyr Leu Gln Ser Ile Leu Thr Val Ser Thr 
145                 150                 155                 160 


Arg Ile Ile Lys Glu Arg Tyr Arg Ser Asn Lys Asn Asp Ala Gln Arg 
                165                 170                 175     


Gly Met Ile Asp Asp Lys Ser Leu Lys Phe Ile Ser Glu Asn Lys Val 
            180                 185                 190         


Lys Phe Val Tyr Asp Glu Asn Gly Lys Arg Ile Thr Ala Pro Asn Lys 
        195                 200                 205             


Lys Tyr Tyr Leu Ser Thr Ile Asp Lys Asp Asn Thr His Leu Ser Tyr 
    210                 215                 220                 


Phe Gly Lys Leu Met Leu Thr Cys Ile Leu Leu Glu Lys Lys Tyr Ala 
225                 230                 235                 240 


Thr Asp Phe Leu Thr Gln Cys His Phe Leu Asp Ala Phe Asn Asp Ser 
                245                 250                 255     


Glu Val Ala Pro Lys Leu Ser Glu Arg Arg Leu Met Leu Glu Val Met 
            260                 265                 270         


Thr Ala Leu Arg Ile Arg Leu Ala Glu Lys Lys Leu Ser Asn Glu Lys 
        275                 280                 285             


Ser Glu Val Gln Ile Ser Leu Asp Ile Leu Asn Glu Leu Lys Lys Cys 
    290                 295                 300                 


Pro Phe Glu Leu Tyr Glu Leu Leu Gly Ser Glu Asp Lys Arg Leu Phe 
305                 310                 315                 320 


Thr Ile Val Ala Asp Thr Gly Glu Thr Ile Leu Leu Arg Arg His Glu 
                325                 330                 335     


Asp Arg Phe Pro Gln Leu Ala Leu Ser Trp Ile Asp Ser Ser Lys Ala 
            340                 345                 350         


Phe Asp His Leu Arg Phe Gln Val Asn Ala Gly Lys Leu Arg Tyr Leu 
        355                 360                 365             


Phe Arg Asp Asn Lys His Cys Ile Asp Gly Gln Thr Arg Met Arg Val 
    370                 375                 380                 


Leu Glu Glu Pro Leu Asn Gly Tyr Arg Arg Leu Met Glu Phe Glu Glu 
385                 390                 395                 400 


Glu Arg Ile Gln Lys Gln Ser Gly Glu Ile Arg Ser Leu Trp Pro Gly 
                405                 410                 415     


Leu Asp Ile Leu Asn Lys Asp Glu Thr Pro Arg Asn Asp Ala Ser Val 
            420                 425                 430         


Leu Pro Tyr Ile Ser Asp Tyr Arg Val Arg Tyr Leu Phe Asp Gly Asp 
        435                 440                 445             


Asn Ile Gly Ile Ser Ile Gly Asp Phe Thr Pro Ser Ile Thr Lys Thr 
    450                 455                 460                 


Asp Glu Thr Lys Tyr Arg Val Thr Gly Lys Thr Ala Asp Cys Cys Leu 
465                 470                 475                 480 


Ser Lys Tyr Glu Leu Leu Gly Leu Leu Phe Tyr His Leu Leu Thr Leu 
                485                 490                 495     


Arg His Gly Asp Asn Lys Arg Ser Thr Lys Asn Ala Glu Asp Ile Ile 
            500                 505                 510         


Ile Asp Ala Ile Lys Arg Tyr Lys Arg Leu Phe Ser Asp Val Lys Glu 
        515                 520                 525             


Gly Ile Leu Lys Pro Ile Lys Glu Glu Asn Ala Asn Gln Leu Gly Asn 
    530                 535                 540                 


Arg Ile Trp Asn Ser Tyr Gly Ile Asn Ile Lys Asp Ile Pro Asp Lys 
545                 550                 555                 560 


Ile Ile Asp Tyr Leu Leu Val Arg Glu Cys Asn Glu Asp Glu Lys Phe 
                565                 570                 575     


Thr Ala Trp Lys Asn Gly Phe Ile Ser Glu Met Leu Gln Ser Thr Lys 
            580                 585                 590         


Asn Arg Ile Lys Arg Phe Glu Lys Asp Ser Glu Ala Val Ile Ser Ser 
        595                 600                 605             


Asp Asn Lys Pro Gly Lys Lys Asn His Val Ser Leu Lys Pro Gly Ala 
    610                 615                 620                 


Tyr Ala Ser Phe Ile Ala Asn Asp Ile Val Phe Phe Gln Glu Cys Gly 
625                 630                 635                 640 


Ala Thr Glu Lys Met Thr Gly Leu Asn Phe Lys Val Met Gln Ser Arg 
                645                 650                 655     


Leu Ala Thr Phe Thr Lys Asp Gly Ser Thr Ser Phe Asn Ile Leu Leu 
            660                 665                 670         


Gln Thr Leu Lys Asn Ala His Leu Val Ser Thr Thr Tyr Gly Lys Gly 
        675                 680                 685             


Asp His Pro Phe Leu Tyr Arg Val Ile Lys Gln Gln Pro Ser Asp Ile 
    690                 695                 700                 


Val Gln Phe Tyr Lys Ile Tyr Leu Asn Glu Lys Val Leu Tyr Leu Gln 
705                 710                 715                 720 


Ser Asp Ile Pro Asp Asn Ala Ile Phe Leu His Gly Glu Arg Lys Arg 
                725                 730                 735     


Trp Glu Asn Arg Asn Glu Gln Tyr Tyr Arg Asp Leu Ala Glu Arg Tyr 
            740                 745                 750         


Leu Gln Arg Pro Ile Gln Leu Pro Arg Gln Leu Phe Glu Ser His Ile 
        755                 760                 765             


Arg Gln Leu Leu Leu Ser Asp Cys Ile Lys Gly Glu Arg Gly Asn Asp 
    770                 775                 780                 


Leu Lys Glu Ala Ile Asn Ser Ala Ala Ser Gln Gly Arg Cys Asn Thr 
785                 790                 795                 800 


Thr Tyr Met Ile Met Glu Tyr Phe Ala Asp Tyr Leu Cys Asp Gly Thr 
                805                 810                 815     


Gln Phe Phe Tyr Gly Leu Phe Asp Gly Asp Leu Ser His Glu Tyr Asn 
            820                 825                 830         


Tyr Arg Phe Tyr Ser Leu Ile Ser Asn Asn Ile Glu Asn Ser Lys Lys 
        835                 840                 845             


Leu Val Leu Thr Leu Lys Lys Gly Asn Asn Ser Lys Glu Ser Pro Phe 
    850                 855                 860                 


Ile Ser Ala Leu Glu Arg Gly Ile His Trp Ser Lys Met Asn Pro Leu 
865                 870                 875                 880 


Met Lys Lys Gly Leu Lys Asn Asp Ser Ser Glu Gly Asp Phe Val His 
                885                 890                 895     


Ala Ala Lys Arg Ala Tyr Lys Glu Met Thr Glu Thr Glu Arg Met Phe 
            900                 905                 910         


Arg Arg Tyr Ala Val Gln Asp Glu Val Leu Phe Leu Ala Ala Lys Ile 
        915                 920                 925             


Thr Ile Arg Arg Ala Leu Gly Leu Ser Glu Gln Tyr Asn Cys Leu Leu 
    930                 935                 940                 


Gly Asp Ile Lys Pro Gln Gly Gly Ser Leu Leu Glu Gln Thr Ile Pro 
945                 950                 955                 960 


Ser Ile Thr Thr Lys His Thr Ile Asn Thr Gly Asn Lys Lys Gln Lys 
                965                 970                 975     


Pro Lys Gln Val Gln Ile Leu Gln Lys Asn Val Lys Leu Lys Asp Phe 
            980                 985                 990         


Gly Lys Val Phe Lys Leu Leu Asn  Asp Arg Arg Ile Phe  Asp Leu Leu 
        995                 1000                 1005             


Phe Asn  Lys Gly Asn Glu Ala  Val Ser Met Thr Asp  Leu Cys Glu 
    1010                 1015                 1020             


Glu Leu  Glu Arg Tyr Asp Arg  His Arg Val Asp Val  Phe Asp Ser 
    1025                 1030                 1035             


Val Leu  Lys Tyr Glu Ser Lys  Ile Thr Lys Gly Tyr  Thr Asn Lys 
    1040                 1045                 1050             


Glu Leu  Met Asn Glu Ser Gly  Gln Ile Asp Phe Lys  Ala Ile Gln 
    1055                 1060                 1065             


Ala Phe  Asp Lys Gln Asn Thr  Thr Ala Asp Lys Glu  Asp Leu Arg 
    1070                 1075                 1080             


Leu Ile  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Gln Tyr Asn 
    1085                 1090                 1095             


Asn Glu  Pro Ile Leu Phe Asp  Lys Asp Ile Pro Glu  Ile Ala Asp 
    1100                 1105                 1110             


Glu Ile  Ser Ile Ile Ala Lys  Asp Ile Glu Glu Asn  Thr Lys 
    1115                 1120                 1125         


<210>  2234
<211>  1179
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2234

Met Ser Ser Lys Asn Glu Ser Tyr Asn Lys Gln Lys Thr Phe Asn His 
1               5                   10                  15      


Tyr Lys Gln Glu Asp Lys Tyr Phe Phe Gly Gly Phe Leu Asn Asn Ala 
            20                  25                  30          


Asp Asp Asn Leu Arg Gln Val Gly Lys Glu Phe Lys Thr Arg Ile Asn 
        35                  40                  45              


Phe Asn His Asn Asn Asn Glu Leu Ala Ser Val Phe Lys Asp Tyr Phe 
    50                  55                  60                  


Asn Lys Glu Lys Ser Val Ala Lys Arg Glu His Ala Leu Asn Leu Leu 
65                  70                  75                  80  


Ser Asn Tyr Phe Pro Val Leu Glu Arg Ile Gln Lys His Thr Asn His 
                85                  90                  95      


Asn Phe Glu Gln Thr Arg Glu Ile Phe Glu Leu Leu Leu Asp Thr Ile 
            100                 105                 110         


Lys Lys Leu Arg Asp Tyr Tyr Thr His His Tyr His Lys Pro Ile Thr 
        115                 120                 125             


Ile Asn Pro Lys Ile Tyr Asp Phe Leu Asp Asp Thr Leu Leu Asp Val 
    130                 135                 140                 


Leu Ile Thr Ile Lys Lys Lys Lys Val Lys Asn Asp Thr Ser Arg Glu 
145                 150                 155                 160 


Leu Leu Lys Glu Lys Leu Arg Pro Glu Leu Thr Gln Leu Lys Asn Gln 
                165                 170                 175     


Lys Arg Glu Glu Leu Ile Lys Lys Gly Lys Lys Leu Leu Glu Glu Asn 
            180                 185                 190         


Leu Glu Asn Ala Val Phe Asn His Cys Leu Arg Pro Phe Leu Glu Glu 
        195                 200                 205             


Asn Lys Thr Asp Asp Lys Gln Asn Lys Thr Val Ser Leu Arg Lys Tyr 
    210                 215                 220                 


Arg Lys Ser Lys Pro Asn Glu Glu Thr Ser Ile Thr Leu Thr Gln Ser 
225                 230                 235                 240 


Gly Leu Val Phe Leu Met Ser Phe Phe Leu His Arg Lys Glu Phe Gln 
                245                 250                 255     


Val Phe Thr Ser Gly Leu Glu Gly Phe Lys Ala Lys Val Asn Thr Ile 
            260                 265                 270         


Lys Glu Glu Glu Ile Ser Leu Asn Lys Asn Asn Ile Val Tyr Met Ile 
        275                 280                 285             


Thr His Trp Ser Tyr Ser Tyr Tyr Asn Phe Lys Gly Leu Lys His Arg 
    290                 295                 300                 


Ile Lys Thr Asp Gln Gly Val Ser Thr Leu Glu Gln Asn Asn Thr Thr 
305                 310                 315                 320 


His Ser Leu Thr Asn Thr Asn Thr Lys Glu Ala Leu Leu Thr Gln Ile 
                325                 330                 335     


Val Asp Tyr Leu Ser Lys Val Pro Asn Glu Ile Tyr Glu Thr Leu Ser 
            340                 345                 350         


Glu Lys Gln Gln Lys Glu Phe Glu Glu Asp Ile Asn Glu Tyr Met Arg 
        355                 360                 365             


Glu Asn Pro Glu Asn Glu Asp Ser Thr Phe Ser Ser Ile Val Ser His 
    370                 375                 380                 


Lys Val Ile Arg Lys Arg Tyr Glu Asn Lys Phe Asn Tyr Phe Ala Met 
385                 390                 395                 400 


Arg Phe Leu Asp Glu Tyr Ala Glu Leu Pro Thr Leu Arg Phe Met Val 
                405                 410                 415     


Asn Phe Gly Asp Tyr Ile Lys Asp Arg Gln Lys Lys Ile Leu Glu Ser 
            420                 425                 430         


Ile Gln Phe Asp Ser Glu Arg Ile Ile Lys Lys Glu Ile His Leu Phe 
        435                 440                 445             


Glu Lys Leu Gly Leu Val Thr Glu Tyr Lys Lys Asn Val Tyr Leu Lys 
    450                 455                 460                 


Glu Thr Ser Asn Ile Asp Leu Ser Arg Phe Pro Leu Phe Pro Ser Pro 
465                 470                 475                 480 


Ser Tyr Val Met Ala Asn Asn Asn Ile Pro Phe Tyr Ile Asp Ser Arg 
                485                 490                 495     


Ser Asn Asn Leu Asp Glu Tyr Leu Asn Gln Lys Lys Lys Ala Gln Ser 
            500                 505                 510         


Gln Asn Arg Lys Arg Asn Leu Thr Phe Glu Lys Tyr Asn Lys Glu Gln 
        515                 520                 525             


Ser Lys Asp Ala Ile Ile Ala Met Leu Gln Lys Glu Ile Gly Val Lys 
    530                 535                 540                 


Asp Leu Gln Gln Arg Ser Thr Ile Gly Leu Leu Ser Cys Asn Glu Leu 
545                 550                 555                 560 


Pro Ser Met Leu Tyr Glu Val Ile Val Lys Asp Ile Lys Gly Ala Glu 
                565                 570                 575     


Leu Glu Asn Lys Ile Ala Gln Lys Ile Arg Glu Gln Tyr Gln Ser Ile 
            580                 585                 590         


Arg Asp Phe Thr Leu Asp Ser Pro Gln Lys Asp Asn Ile Pro Thr Thr 
        595                 600                 605             


Leu Thr Lys Thr Ile Ser Thr Asp Thr Ser Val Thr Phe Glu Asn Gln 
    610                 615                 620                 


Pro Ile Asp Ile Pro Arg Leu Lys Asn Ala Leu Gln Lys Glu Leu Thr 
625                 630                 635                 640 


Leu Thr Gln Glu Lys Leu Leu Asn Val Lys Gln His Glu Ile Glu Val 
                645                 650                 655     


Asp Asn Tyr Asn Arg Asn Lys Asn Thr Tyr Lys Phe Lys Asn Gln Pro 
            660                 665                 670         


Lys Asp Lys Val Asp Asp Asn Lys Leu Gln Arg Lys Tyr Val Phe Tyr 
        675                 680                 685             


Arg Asn Glu Ile Gly Gln Glu Ala Asn Trp Leu Ala Ser Asp Leu Ile 
    690                 695                 700                 


His Phe Met Lys Asn Lys Ser Leu Trp Lys Gly Tyr Met His Asn Glu 
705                 710                 715                 720 


Leu Gln Ser Phe Leu Ala Phe Phe Glu Asp Lys Lys Asn Asp Cys Ile 
                725                 730                 735     


Ala Leu Leu Glu Thr Val Phe Asn Leu Lys Glu Asp Cys Ile Leu Thr 
            740                 745                 750         


Lys Asp Leu Lys Asn Leu Phe Leu Lys His Gly Asn Phe Ile Asp Phe 
        755                 760                 765             


Tyr Lys Glu Tyr Leu Lys Leu Lys Glu Asp Phe Leu Ser Thr Glu Ser 
    770                 775                 780                 


Thr Phe Leu Glu Asn Gly Phe Ile Gly Leu Pro Pro Lys Ile Leu Lys 
785                 790                 795                 800 


Lys Glu Leu Ser Lys Arg Leu Lys Tyr Ile Phe Ile Val Phe Gln Lys 
                805                 810                 815     


Arg Gln Phe Ile Ile Lys Glu Leu Glu Glu Lys Lys Asn Asn Leu Tyr 
            820                 825                 830         


Ala Asp Ala Ile Asn Leu Ser Arg Gly Ile Phe Asp Glu Lys Pro Thr 
        835                 840                 845             


Met Ile Pro Phe Lys Lys Pro Asn Pro Asp Glu Phe Ala Ser Trp Phe 
    850                 855                 860                 


Val Ala Ser Tyr Gln Tyr Asn Asn Tyr Gln Ser Phe Tyr Glu Leu Thr 
865                 870                 875                 880 


Pro Asp Lys Ile Glu Asn Asp Lys Lys Lys Lys Tyr Lys Asn Leu Arg 
                885                 890                 895     


Ala Ile Asn Lys Val Lys Ile Gln Asp Tyr Tyr Leu Lys Leu Met Val 
            900                 905                 910         


Asp Thr Leu Tyr Gln Asp Leu Phe Asn Gln Pro Leu Asp Lys Ser Leu 
        915                 920                 925             


Ser Asp Phe Tyr Val Ser Lys Ala Glu Arg Glu Lys Ile Lys Ala Asp 
    930                 935                 940                 


Ala Lys Ala Tyr Gln Lys Cys Asn Asp Ser Ser Leu Trp Asn Lys Val 
945                 950                 955                 960 


Ile His Leu Ser Leu Gln Asn Asn Arg Ile Thr Ala Asn Pro Lys Leu 
                965                 970                 975     


Lys Asp Ile Gly Lys Tyr Lys Arg Ala Leu Gln Asp Glu Lys Ile Ala 
            980                 985                 990         


Thr Leu Leu Thr Tyr Asp Asp Arg  Thr Trp Ser Tyr Ala  Leu Gln Lys 
        995                 1000                 1005             


Pro Glu  Lys Glu Asn Glu Asn  Asp Tyr Lys Glu Leu  His Tyr Thr 
    1010                 1015                 1020             


Ala Leu  Asn Met Glu Leu Gln  Glu Tyr Glu Lys Val  Arg Ser Lys 
    1025                 1030                 1035             


Lys Leu  Leu Lys Gln Val Gln  Gln Leu Glu Lys Gln  Ile Leu Glu 
    1040                 1045                 1050             


Glu Tyr  Thr Asp Phe Ser Ser  Thr Gln Ile His Pro  Ala Asp Phe 
    1055                 1060                 1065             


Glu Arg  Glu Gly Asn Pro Asn  Phe Lys Lys Tyr Leu  Ala Asn Ser 
    1070                 1075                 1080             


Ile Leu  Ala Asn Glu Asp Glu  Ile Asp Lys Leu Pro  Glu Lys Val 
    1085                 1090                 1095             


Glu Ala  Met Met Lys Leu Asp  Glu Thr Ile Thr Asn  Pro Ile Ile 
    1100                 1105                 1110             


Lys Lys  Ala Ile Val Leu Ile  Ile Ile Arg Asn Lys  Met Ala His 
    1115                 1120                 1125             


Asn Gln  Tyr Pro Pro Lys Phe  Ile Tyr Asp Leu Ala  Thr Arg Phe 
    1130                 1135                 1140             


Val Pro  Lys Lys Glu Glu Glu  Tyr Phe Ala Cys Tyr  Phe Asn Arg 
    1145                 1150                 1155             


Val Phe  Glu Thr Ile Thr Thr  Glu Leu Trp Glu Asn  Lys Lys Glu 
    1160                 1165                 1170             


Lys Ala  Lys Glu Ile Val 
    1175                 


<210>  2235
<211>  983
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2235

Leu Phe Lys Leu Phe Leu Ala Cys Cys Ile Asn Cys Asp Asn Phe Asp 
1               5                   10                  15      


Gly Arg Phe Ala Ile Phe Glu Val Asn Ile Leu Leu Ile Thr Met Ser 
            20                  25                  30          


Asn Glu Ile Gly Ala Phe Arg Glu His Gln Phe Ala Tyr Ala Pro Gly 
        35                  40                  45              


Asn Glu Lys Gln Glu Glu Ala Thr Phe Ala Thr Tyr Phe Asn Leu Ala 
    50                  55                  60                  


Leu Ser Asn Val Glu Gly Met Met Phe Gly Glu Val Glu Ser Asn Pro 
65                  70                  75                  80  


Asp Lys Ile Glu Lys Ser Leu Asp Thr Leu Pro Pro Ala Ile Leu Arg 
                85                  90                  95      


Gln Ile Ala Ser Phe Ile Trp Leu Ser Lys Glu Asp His Pro Asp Lys 
            100                 105                 110         


Ala Tyr Ser Thr Glu Glu Val Lys Val Ile Val Thr Asp Leu Val Arg 
        115                 120                 125             


Arg Leu Cys Phe Tyr Arg Asn Tyr Phe Ser His Cys Phe Tyr Leu Asp 
    130                 135                 140                 


Thr Gln Tyr Phe Tyr Ser Asp Glu Leu Val Asp Thr Thr Ala Ile Gly 
145                 150                 155                 160 


Glu Lys Leu Pro Tyr Asn Phe His His Phe Ile Thr Asn Arg Leu Phe 
                165                 170                 175     


Arg Tyr Ser Leu Pro Glu Ile Thr Leu Phe Arg Trp Asn Glu Gly Glu 
            180                 185                 190         


Arg Lys Tyr Glu Ile Leu Arg Asp Gly Leu Ile Phe Phe Cys Cys Leu 
        195                 200                 205             


Phe Leu Lys Arg Gly Gln Ala Glu Arg Phe Leu Asn Glu Leu Arg Phe 
    210                 215                 220                 


Phe Lys Arg Thr Asp Glu Glu Gly Arg Ile Lys Arg Thr Ile Phe Thr 
225                 230                 235                 240 


Lys Tyr Cys Thr Arg Glu Ser His Lys His Ile Gly Ile Glu Glu Gln 
                245                 250                 255     


Asp Phe Leu Ile Phe Gln Asp Ile Ile Gly Asp Leu Asn Arg Val Pro 
            260                 265                 270         


Lys Val Cys Asp Gly Val Val Asp Leu Ser Lys Glu Asn Glu Arg Tyr 
        275                 280                 285             


Ile Lys Asn Arg Glu Thr Ser Asn Glu Ser Asp Glu Asn Lys Ala Arg 
    290                 295                 300                 


Tyr Arg Leu Leu Ile Arg Glu Lys Asp Lys Phe Pro Tyr Tyr Leu Met 
305                 310                 315                 320 


Arg Tyr Ile Val Asp Phe Gly Val Leu Pro Cys Ile Thr Phe Lys Gln 
                325                 330                 335     


Asn Asp Tyr Ser Thr Lys Glu Gly Arg Gly Gln Phe His Tyr Gln Asp 
            340                 345                 350         


Ala Ala Val Ala Gln Glu Glu Arg Cys Tyr Asn Phe Val Val Arg Asn 
        355                 360                 365             


Gly Asn Val Tyr Tyr Ser Tyr Met Pro Gln Ala Gln Asn Val Val Arg 
    370                 375                 380                 


Ile Ser Glu Leu Gln Gly Thr Ile Ser Val Glu Glu Leu Arg Asn Met 
385                 390                 395                 400 


Val Tyr Ala Ser Ile Asn Gly Lys Asp Val Asn Lys Ser Val Glu Gln 
                405                 410                 415     


Tyr Leu Tyr His Leu His Leu Leu Tyr Glu Lys Ile Leu Thr Ile Ser 
            420                 425                 430         


Gly Gln Thr Ile Lys Glu Gly Arg Val Asp Val Glu Asp Tyr Arg Pro 
        435                 440                 445             


Leu Leu Asp Lys Leu Leu Leu Arg Pro Ala Ser Asn Gly Glu Glu Leu 
    450                 455                 460                 


Arg Arg Glu Leu Arg Lys Leu Leu Pro Lys Arg Val Cys Asp Leu Leu 
465                 470                 475                 480 


Ser Asn Arg Phe Asp Cys Ser Glu Gly Val Ser Ala Val Glu Lys Arg 
                485                 490                 495     


Leu Lys Ala Ile Leu Leu Arg His Glu Gln Leu Leu Leu Ser Gln Asn 
            500                 505                 510         


Pro Ala Leu His Ile Asp Lys Ile Lys Ser Val Ile Asp Tyr Leu Tyr 
        515                 520                 525             


Leu Phe Phe Ser Asp Asp Glu Lys Phe Arg Gln Gln Pro Thr Glu Lys 
    530                 535                 540                 


Ala His Arg Gly Leu Lys Asp Glu Glu Phe Gln Met Tyr His Tyr Leu 
545                 550                 555                 560 


Val Gly Asp Tyr Asp Ser His Pro Leu Ala Leu Trp Lys Glu Leu Glu 
                565                 570                 575     


Ala Ser Gly Arg Leu Lys Pro Glu Met Arg Lys Leu Thr Ser Ala Thr 
            580                 585                 590         


Ser Leu His Gly Leu Tyr Met Leu Cys Leu Lys Gly Thr Val Glu Trp 
        595                 600                 605             


Cys Arg Lys Gln Leu Met Ser Ile Gly Lys Gly Thr Ala Lys Val Glu 
    610                 615                 620                 


Ala Ile Ala Asp Arg Val Gly Leu Lys Leu Tyr Asp Lys Leu Lys Glu 
625                 630                 635                 640 


Tyr Thr Pro Glu Gln Leu Glu Arg Glu Val Lys Leu Val Val Met His 
                645                 650                 655     


Gly Tyr Ala Ala Ala Ala Thr Pro Lys Pro Lys Ala Gln Ala Ala Ile 
            660                 665                 670         


Pro Ser Lys Leu Thr Glu Leu Arg Phe Tyr Ser Phe Leu Gly Lys Arg 
        675                 680                 685             


Glu Met Ser Phe Ala Ala Phe Ile Arg Gln Asp Lys Lys Ala Gln Lys 
    690                 695                 700                 


Leu Trp Leu Arg Asn Phe Tyr Thr Val Glu Asn Ile Lys Thr Leu Gln 
705                 710                 715                 720 


Lys Arg Gln Ala Ala Ala Asp Ala Ala Cys Lys Lys Leu Tyr Asn Leu 
                725                 730                 735     


Val Gly Glu Val Glu Arg Val His Thr Asn Asp Lys Val Leu Val Leu 
            740                 745                 750         


Val Ala Gln Arg Tyr Arg Glu Arg Leu Leu Asn Val Gly Ser Lys Cys 
        755                 760                 765             


Ala Val Thr Leu Asp Asn Pro Glu Arg Gln Gln Lys Leu Ala Asp Val 
    770                 775                 780                 


Tyr Glu Val Gln Asn Ala Trp Leu Ser Ile Arg Phe Asp Asp Leu Asp 
785                 790                 795                 800 


Phe Thr Leu Thr His Val Asn Leu Ser Asn Leu Arg Lys Ala Tyr Asn 
                805                 810                 815     


Leu Ile Pro Arg Lys His Ile Leu Ala Phe Lys Glu Tyr Leu Asp Asn 
            820                 825                 830         


Arg Val Lys Gln Lys Leu Cys Glu Glu Cys Arg Asn Val Arg Arg Lys 
        835                 840                 845             


Glu Asp Leu Cys Thr Cys Cys Ser Pro Arg Tyr Ser Asn Leu Thr Ser 
    850                 855                 860                 


Trp Leu Lys Glu Asn His Ser Glu Ser Ser Ile Glu Arg Glu Ala Ala 
865                 870                 875                 880 


Thr Met Met Leu Leu Asp Val Glu Arg Lys Leu Leu Ser Phe Leu Leu 
                885                 890                 895     


Asp Glu Arg Arg Lys Ala Ile Ile Glu Tyr Gly Lys Phe Ile Pro Phe 
            900                 905                 910         


Ser Ala Leu Val Lys Glu Cys Arg Leu Ala Asp Ala Gly Leu Cys Gly 
        915                 920                 925             


Ile Arg Asn Asp Val Leu His Asp Asn Val Ile Ser Tyr Ala Asp Ala 
    930                 935                 940                 


Ile Gly Lys Leu Ser Ala Tyr Phe Pro Lys Glu Ala Ser Glu Ala Val 
945                 950                 955                 960 


Glu Tyr Ile Arg Arg Thr Lys Glu Val Arg Glu Gln Arg Arg Glu Glu 
                965                 970                 975     


Leu Met Ala Asn Ser Ser Gln 
            980             


<210>  2236
<211>  1123
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2236

Met Ile Thr Glu Gln Ala Lys Val Glu Glu Ser Thr Lys Ser Val Tyr 
1               5                   10                  15      


Gln Asn Pro Gly Tyr Phe Gly Ala Phe Leu Asn Met Ala Val Leu Asn 
            20                  25                  30          


Val Phe Ala Ile Ser Asn Gln Ile Val Lys Thr Phe Lys Glu Leu Asn 
        35                  40                  45              


Gly Val Glu Leu Lys Asn Asp Ser Asp Ile Lys Cys Ser Asp Lys Asn 
    50                  55                  60                  


Leu Leu Leu Gln Ile Phe Asn Asn Ala Asn Leu Pro Ser Glu Ile Lys 
65                  70                  75                  80  


Trp Asn Val Phe Asn Tyr Leu Tyr Lys Arg Gln His Phe Pro Val Leu 
                85                  90                  95      


Lys Tyr Phe Leu Ser Cys Tyr His Asp Asp Gly Asn Gln Arg Phe Tyr 
            100                 105                 110         


Asn Asn Glu Thr Lys Leu Phe Glu Arg Thr His Gln Phe Leu Gln Glu 
        115                 120                 125             


Ser Phe Asn Ala Leu Val Ala Leu Arg Asn Asp Phe Thr His Tyr Ile 
    130                 135                 140                 


Ala Ile Asp Asp Gln Gly Asn Glu Val Glu Lys Lys Tyr Glu Val His 
145                 150                 155                 160 


Gln Asn Leu Ala Asn Leu Met Gln Asp Glu Leu Leu His Ala Ser Ile 
                165                 170                 175     


Asn Phe Ser Lys Thr Arg Phe Glu Gln Thr Gln Ile Glu Glu Asp Phe 
            180                 185                 190         


Lys Phe Leu Gln His Val Lys Leu Ile Glu Asp Asn Val Pro Lys Leu 
        195                 200                 205             


Thr Glu Gln Gly Leu Tyr Phe Phe Thr Ser Leu Phe Leu Glu Arg Gly 
    210                 215                 220                 


Lys Thr Tyr Leu Phe Leu Lys Lys Leu Thr Gly Phe Lys Asn Glu Thr 
225                 230                 235                 240 


Thr Pro Ser Phe Arg Ala Thr Leu Lys Val Phe Ser Ala Phe Cys Leu 
                245                 250                 255     


Lys Leu Pro Lys Ala Lys Ile Gln Asn Asp Asp Tyr Lys Gln Ser Leu 
            260                 265                 270         


Leu Met Glu Met Leu Pro Glu Leu Ala Lys Cys Pro Ala Ile Leu Tyr 
        275                 280                 285             


Asn Arg Leu Ser Glu Asp Asp Lys Gln Lys Phe Lys Thr Lys Ile Ser 
    290                 295                 300                 


Asn Glu Ala Arg Lys Asn Ile Glu Leu Asn Ser Thr Asp Tyr Lys Asn 
305                 310                 315                 320 


Ile Asp Ile Gln Gln Leu Glu Leu Glu Ile Asn Asp Leu Val Ser Gln 
                325                 330                 335     


Lys Arg Arg Ser Asp Arg Phe His Tyr Phe Ala Leu Arg Phe Leu Asp 
            340                 345                 350         


Glu Leu Asp Val Phe Lys Asn Ile Lys Phe Gln Ile Lys Leu Gly Arg 
        355                 360                 365             


Leu Met Phe Ser Glu Asp Asp Ile Arg Asp Lys Glu Ile Leu Gly Glu 
    370                 375                 380                 


Ile Gln Ala Arg Lys Ile Thr Lys Thr Val Cys Ala Phe Gly Lys Leu 
385                 390                 395                 400 


Ser Glu Leu Glu Lys Met Ala Glu Asn Gln Leu Val Ser Gln Leu Lys 
                405                 410                 415     


Gly His Thr Asn Glu Trp Lys Phe Asp Gln Phe Ala Pro His Tyr Asn 
            420                 425                 430         


Met Gln His Asn Lys Ile Ala Phe Cys Phe Ser Glu Gln Val Lys Tyr 
        435                 440                 445             


Pro Val Leu Lys Lys Glu Asp Glu Lys Ala Asn Gln Pro Asp Gly Tyr 
    450                 455                 460                 


Leu Ser Leu His Ala Leu Pro Lys Leu Ile Leu Thr Ser Ile Leu Glu 
465                 470                 475                 480 


Ser Asp Lys Leu Glu Thr Leu Ile Lys Glu Phe Phe Lys Asn Asn Ser 
                485                 490                 495     


Asp Thr Ile Leu Asn Val Leu Thr Leu Lys Glu Ile Lys Asp Gln Leu 
            500                 505                 510         


Asn Phe Gly Ser Asp Pro Lys Glu Leu Thr Arg Lys Leu Ile Asp Tyr 
        515                 520                 525             


Asn Lys Asn Pro Arg Ile Leu Ser Gly Lys Glu Lys Glu Glu Lys Arg 
    530                 535                 540                 


Asp Leu Ala Glu Arg Met Glu Lys Glu Ile Asn Asp Arg Glu Asp Tyr 
545                 550                 555                 560 


Ala Ile Lys Met Lys Ser Arg Asn Lys Lys Leu Asn Val Ala Leu Gln 
                565                 570                 575     


Asn Tyr Asn Leu His His Asn Gln Leu Pro Ser Ile Val Lys Asp Tyr 
            580                 585                 590         


Leu Leu Asn Ile Gln Asn Pro Ser Leu Ala Leu Lys Ile Asn Thr Tyr 
        595                 600                 605             


Leu Lys Ala Glu Lys Leu Thr Phe Gln Gln Ser Leu Lys Lys Ile Lys 
    610                 615                 620                 


Lys Gln Gln Glu Leu Asn His Thr Ile Lys Leu Gly Glu Leu Ala Thr 
625                 630                 635                 640 


Ile Ile Thr Arg Asp Met Met Asn Met Leu Val Asp Thr Ala Leu Lys 
                645                 650                 655     


Ser Lys Leu Thr Pro Pro Tyr Thr Asn Lys Ile Gln Asn Ala Ile Ala 
            660                 665                 670         


His Phe Gly Leu Lys Lys Asn Glu Leu Ile Asn Met Leu Thr Glu Trp 
        675                 680                 685             


Lys Ile Leu Asp Asn Arg Ala Gly His Val Phe Leu Gln Lys Asn His 
    690                 695                 700                 


Ile Lys Asn Ser Lys Gly Val Val Asp Phe Tyr Glu Asn Tyr Val Glu 
705                 710                 715                 720 


Gln Lys Ile Lys Tyr Ile Asp Asn Ile Lys Ala Lys Thr Lys Asn Leu 
                725                 730                 735     


Phe Gly Leu Lys Pro Asp Ala Asn Val Ser Asn Gln Leu Pro Tyr Lys 
            740                 745                 750         


Tyr Arg Lys Leu Thr Glu Lys Tyr Gln Lys Pro Ala Ile Lys Asp Tyr 
        755                 760                 765             


Val Lys Gln Lys Gln Lys Val Pro Val Asn Leu Pro Leu Asn Leu Phe 
    770                 775                 780                 


Asp Glu Val Leu Phe Ser Ala Leu Arg Ser Lys Val Asn Thr Ser Lys 
785                 790                 795                 800 


Thr Gly Leu Asn Asn Leu Leu Ala Ala Tyr Leu Lys Asp Asp Ser Gln 
                805                 810                 815     


Thr Phe Tyr Ser Phe Asn Arg Leu Tyr Asn Ile Asn Lys Glu Pro Thr 
            820                 825                 830         


Thr Val Asp Val Asn Ser Lys Ser Leu Lys Glu Ile Lys Ile Glu Phe 
        835                 840                 845             


Gly Lys Pro Val Phe Glu Asn Glu Lys Lys Ile Arg Tyr Gln Gln Met 
    850                 855                 860                 


Ile Asp Arg Val Met Lys Met Met Cys Ile Glu Leu Met Gln Lys Gln 
865                 870                 875                 880 


Asp Thr Asp Leu Thr Leu Gly Val Ser Gln Leu Glu Leu Ala Lys Leu 
                885                 890                 895     


Ser Asn Ala Thr Pro Asp Lys Asn Phe Leu Asn Ala Pro Val Ser Phe 
            900                 905                 910         


Lys Arg Thr Val Asn Ala Asp Lys Glu Leu Ile Ala Glu Asp Asn Glu 
        915                 920                 925             


Glu Thr Lys Gln Lys Val Ala Glu Ser Ile Arg Ala Tyr Lys Ala Gly 
    930                 935                 940                 


Thr Lys Glu Val Ile Glu His Trp Tyr Ser Trp Thr Val Lys Asp Tyr 
945                 950                 955                 960 


Gly Arg Phe Thr Arg Leu Leu Val Asp Arg Arg Leu Glu Asn Leu Leu 
                965                 970                 975     


Lys His Phe Glu Gly Asp Ala Ile Pro Phe Ser Ile Ile Lys Tyr Glu 
            980                 985                 990         


Leu Asp Asn Tyr Asp Lys Tyr Trp  His Lys Ile Leu Asp  Glu Leu Leu 
        995                 1000                 1005             


Lys Val  Glu Lys Ala Ile Phe  Glu Lys Asp Gly Glu  Arg Ile Lys 
    1010                 1015                 1020             


Ala Leu  Gln Leu Gly Ser Lys  Tyr Glu His Val Gln  Phe Gly Lys 
    1025                 1030                 1035             


Tyr Val  Lys Trp Leu Lys Glu  Lys Ser Ile Asn Tyr  Asp Lys Lys 
    1040                 1045                 1050             


Leu Phe  Leu Asn Val Arg Asn  Lys Phe Ser His Ser  Gln Phe Leu 
    1055                 1060                 1065             


Glu Ile  Asp Lys Val Gly Leu  Ser Lys Ile Ser Glu  Gln Ile Thr 
    1070                 1075                 1080             


Tyr Asn  Phe Asn Glu Asn Tyr  Leu Thr Gly Asp Trp  Ile Asn Thr 
    1085                 1090                 1095             


Asn Tyr  Glu Ser Ile Ala Ser  Lys Val Tyr Thr Lys  Phe Lys Thr 
    1100                 1105                 1110             


Glu Ile  Asp Glu Ile Leu Lys  Gln Ile Ala 
    1115                 1120             


<210>  2237
<211>  1145
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2237

Met Thr Leu Pro Thr Asp Asn Thr Phe Ile Glu Lys Ala Asp Gln Glu 
1               5                   10                  15      


Ile Leu Gly Lys Asn Lys Leu Phe Phe Gly Ala Tyr Leu Asn Met Ala 
            20                  25                  30          


Asn His Asn Ala Tyr Leu Ile Ile Lys Asp Ile Ser Glu Arg Leu Lys 
        35                  40                  45              


Gln Glu Asp Ala Leu Asp Ile Asp Ala Pro Ser Asp Glu Asp Asn Leu 
    50                  55                  60                  


Ala Tyr Ala Asp Ile Phe Ser Lys Ile Leu Lys Lys Ala Ser Asp Lys 
65                  70                  75                  80  


Asn Pro Lys Asn Arg Pro Gln Ala Thr Ile Ile Asp Lys Val Thr Asn 
                85                  90                  95      


Leu Leu Ile His His Phe Pro Ala Phe Glu Val Phe Ala Tyr Glu His 
            100                 105                 110         


Pro Phe Glu Gln Gln Asn Ser Tyr Pro Glu Leu Leu Tyr Gln Lys Leu 
        115                 120                 125             


Thr Thr Ala Leu Lys Leu Leu Asn Asp Leu Arg Asn Glu His Ser His 
    130                 135                 140                 


Phe Tyr Tyr Lys Gly Ser Phe Asp Ile Asp Thr Val Phe Ser Ala Ala 
145                 150                 155                 160 


Gln Glu Glu Ile Thr Arg Phe Pro Tyr Leu Thr Pro Glu Asp Ile Glu 
                165                 170                 175     


Glu Leu Glu Tyr Tyr Lys Asn Asp Leu Leu Glu Pro Leu Thr Tyr Phe 
            180                 185                 190         


Lys Lys Tyr Gly Phe Val Phe Phe Ile Cys Thr Phe Leu Glu Lys Arg 
        195                 200                 205             


Tyr Ala Arg Tyr Met Leu Lys Glu Lys Gln Leu Asp Leu Ile Ala Ser 
    210                 215                 220                 


Asp Lys Glu Arg Asp Ala Thr Leu Glu Asn Phe Thr Asn Tyr Ser Cys 
225                 230                 235                 240 


Arg Leu Pro Arg Pro Lys Leu Glu Ser Ser Val Ile Glu Leu Asp Met 
                245                 250                 255     


Leu Asn Glu Leu Ser Arg Cys Pro Lys Gly Ile His Asp Val Leu Ser 
            260                 265                 270         


Ser Pro Met Glu Lys Val Leu Leu Lys Thr Asp Ala Lys Asp Asp Pro 
        275                 280                 285             


Asn Gln Val Pro Met Ile Arg His Asn Asp Arg Phe Pro Tyr Phe Ala 
    290                 295                 300                 


Leu Ser Tyr Phe Asp Lys Met Glu Arg Phe Pro Ala Met Arg Phe His 
305                 310                 315                 320 


Ile Trp Ala Gly Lys Thr Arg Leu Ala Phe Tyr Gly Lys Lys Leu Gly 
                325                 330                 335     


Lys Lys Asn Val Leu Arg Asp Ile Gln Glu Asn Val Thr Ile Tyr Ala 
            340                 345                 350         


Arg Leu Asn Asp Ile Lys Ala Asp Lys Ile Pro Asp Asn Trp Lys Asp 
        355                 360                 365             


Lys Ile Asp Val Glu Asp Ser Glu Glu Asn Lys Glu Lys Ala Lys Ile 
    370                 375                 380                 


Gln Ser Tyr Ser Pro His Tyr Asn Ile His Asn Asn Arg Ile Ala Ile 
385                 390                 395                 400 


Lys Phe Ile Asp Thr Gln Lys Asp Glu Leu Asp Thr Glu Asn Phe Ser 
                405                 410                 415     


Glu Ile Lys Ser Lys Pro Gln Asp Pro Thr Lys Asp Lys Gln Leu Lys 
            420                 425                 430         


Tyr Thr Val Thr His Ala Leu Pro Asn Ala Ile Leu Ser Thr Tyr Glu 
        435                 440                 445             


Leu Gln Asn Leu Phe Leu Tyr Asp Tyr Leu Tyr Arg Thr Tyr Lys Asp 
    450                 455                 460                 


Gln Lys Val Leu Ala Arg Pro Ala Asp Ser Phe Ile Arg Asn Tyr Ile 
465                 470                 475                 480 


Ser Ser Phe His Arg Phe Cys Lys Asp Val Lys Ser Gly Lys Ile Gln 
                485                 490                 495     


Pro Val Ser Pro His Asp Phe Glu Arg Leu Thr Glu His Thr Arg Ser 
            500                 505                 510         


Thr Thr Arg Asp Leu Gly Asn Arg Glu Glu Glu Leu Glu Ile Arg Lys 
        515                 520                 525             


Glu Ala Leu Gln Lys Lys Lys Leu Asp Asn Tyr Gly Leu Lys Val Lys 
    530                 535                 540                 


Asn Leu Pro Asp Ala Leu Arg Glu Tyr Leu Leu Gly Tyr Lys Gln Glu 
545                 550                 555                 560 


Thr Tyr Thr Glu Ile Ala Leu Asn Lys Leu Arg Gly Lys Ile Lys Gln 
                565                 570                 575     


Thr Lys Val His Tyr Lys Leu Ala Thr Lys Asp Asp Leu Phe Leu Asp 
            580                 585                 590         


Gly Lys Thr Asp Leu Lys Ser Gly Lys Ile Gly Asp Phe Leu Ala Ala 
        595                 600                 605             


Asp Ile Val Phe Leu Lys Pro Leu Asp Ala Asn Arg Thr Gly Lys Pro 
    610                 615                 620                 


Asn Asn Gln Gln Phe Asn Glu Leu Gln Lys Ala Ile Ala Arg Phe His 
625                 630                 635                 640 


Ser Gln Lys Lys Asp Ala Glu Asp Phe Ile Asn Glu Glu Leu Gln Ile 
                645                 650                 655     


Lys Glu Gln Ser Leu Pro His Ala His Pro Phe Leu Tyr Lys Ile Gln 
            660                 665                 670         


Phe Glu Glu His Thr Asp Val Gln Ser Phe Tyr Ile Lys Tyr Leu Glu 
        675                 680                 685             


Leu Lys Ile Glu Trp Leu Glu Cys Thr Lys Arg Glu Ile Gln Gly Lys 
    690                 695                 700                 


Ser Asp Tyr Leu Lys Pro Trp Gln Trp Arg Glu Glu Ala Asp Lys Cys 
705                 710                 715                 720 


Lys Gln Tyr Gly Ile Asp Ile Lys Pro Glu Gly Leu Ser Asp Ala Ala 
                725                 730                 735     


Thr Glu Asn Lys Tyr Gly Tyr Phe Leu Gln Ile Asn Thr Lys Lys Gly 
            740                 745                 750         


Asn Glu Arg Asn Tyr Thr Asn Ala Thr Thr Pro Ser Lys Ala Asn Ser 
        755                 760                 765             


Lys Glu Phe Glu Ser Leu Glu Ser Lys Ser Pro Val Phe Leu Pro Arg 
    770                 775                 780                 


Gly Leu Phe Asn Asp Ala Ile Ile Asp Ala Met Met Lys Ile Asp Glu 
785                 790                 795                 800 


Phe Lys Gly Lys Ile Lys Glu Gly Asp Asn Ile Val Arg Cys Leu Asp 
                805                 810                 815     


Val Leu Ala Glu Gly Asp Arg Gln Thr Phe Tyr Asp Phe Glu Arg Ser 
            820                 825                 830         


Tyr Thr Val Gly Lys Ala Ala Pro Thr Ser Val Thr Ile His Gln Gly 
        835                 840                 845             


Ala Asn Gly Glu Tyr Ile Lys Asn Lys Leu Arg Ser Ile Lys Pro Ile 
    850                 855                 860                 


Ile Lys Lys Leu Arg Thr Gln Gln Asn Ala Lys Asp Ala Lys Tyr Lys 
865                 870                 875                 880 


Asp Lys Lys Ile Leu Gln Asn His Ile Lys Ala Leu Gln Ala Ile Ser 
                885                 890                 895     


Asp Asn Glu Arg Ser Ile Arg Phe Ile Arg Ala Asn Asp Arg Thr Leu 
            900                 905                 910         


Phe Leu Met Ile Lys His Ile Phe Ser Glu His Lys Ser Tyr Val Val 
        915                 920                 925             


Glu Gly Ser Lys Leu Thr Lys Ser Ile Asn Thr Leu Pro Trp Lys Leu 
    930                 935                 940                 


Asn Lys Val Gly Tyr Glu Ile Lys Glu Asn Asn Ile Leu Asn Glu Ile 
945                 950                 955                 960 


Leu Pro Met Asn Ile Gln Phe Asn Gln Lys Ser Ile Tyr Thr Glu Gly 
                965                 970                 975     


Glu His Gly Thr Asp Pro Leu Asn Lys Leu Ser Ile Lys His Tyr Gly 
            980                 985                 990         


Lys Phe Arg Lys Leu Leu Lys Asp  Lys Arg Leu Ser Asn  Lys Lys Lys 
        995                 1000                 1005             


Pro Gly  Leu Leu Asn Tyr Tyr  Thr Asp Gln Asn Val  Arg Trp Ser 
    1010                 1015                 1020             


Ala Ile  Asn Lys Glu Leu Glu  Tyr Tyr Asp Glu Asn  Arg Asp Arg 
    1025                 1030                 1035             


Leu Leu  Asp Val Ile Tyr Lys  Phe Glu Lys Ala Val  Trp Glu Asn 
    1040                 1045                 1050             


Glu Glu  Cys Arg Glu Glu Leu  Lys Glu Asn Ile Arg  Leu Gly Tyr 
    1055                 1060                 1065             


Ile Asn  His Ala Thr Gln Leu  Lys Ala Val Gly Lys  Ile Val Arg 
    1070                 1075                 1080             


Gly Phe  Thr Thr Ser Lys Gln  Asp Gln Leu Ala Leu  Leu Arg Asn 
    1085                 1090                 1095             


Lys Phe  Leu His Asn Gln Ile  Pro Tyr Thr Glu Asn  Leu Lys Thr 
    1100                 1105                 1110             


Gly Trp  Val Asp Asn Asn Pro  Glu Tyr Pro Leu Ile  Thr Gln Ala 
    1115                 1120                 1125             


Leu Leu  Glu Leu Ala Ile Ile  Glu Tyr Gln Asn Ile  Thr Lys Asn 
    1130                 1135                 1140             


Ile Ile  
    1145 


<210>  2238
<211>  1260
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2238

Val Arg His Gln Gly Ala Arg Thr Pro Asp Ala Arg Gln Pro Arg His 
1               5                   10                  15      


Gly Arg His Gly Arg Asn Val Leu Ser Arg Ser Pro Leu Thr Thr Asp 
            20                  25                  30          


Tyr Cys Gly Arg Ala Ala Val Arg Pro Ala Leu Phe Val Ser Pro Leu 
        35                  40                  45              


Gly His Lys Arg Gln Ser Leu Ile Ser Arg Tyr Pro Ser Ile Pro Asn 
    50                  55                  60                  


Ser Phe Met Lys Asn Asp Tyr Asn Ser Asn Ser Pro Lys Lys Thr Val 
65                  70                  75                  80  


Ala Pro Lys His Phe Ala Leu Pro Glu Ala Met Gly Gly Glu Thr Pro 
                85                  90                  95      


Leu Asn Glu Asp Glu Lys Lys Leu Lys Ala Val Ala Gly Thr Tyr Phe 
            100                 105                 110         


Glu Arg Ala Met Asn Asn Ala Ala Gln Thr Leu Arg Tyr Ile Phe Asn 
        115                 120                 125             


Asn Lys Leu Gln Leu Thr Pro Thr Pro Asp Phe Lys Asp Leu Glu Lys 
    130                 135                 140                 


Thr Leu Arg Gly Leu Ala Glu Asn Ser Ala Leu Ala Asp Pro Leu Lys 
145                 150                 155                 160 


His Asp Glu Phe Arg Lys Leu Val Phe His His Ile Pro Leu Phe Lys 
                165                 170                 175     


Ala Leu Glu Asp Tyr Arg Thr Arg Pro Pro Lys Pro Gln Lys Gly Ser 
            180                 185                 190         


Phe Ser Gln Pro Lys Glu Val Arg Lys Leu Tyr Ser Ala Ala Asp Ile 
        195                 200                 205             


Leu Ile Asp Leu Ala Asp Met Val Gly Ala Leu Asn His Tyr Arg Asn 
    210                 215                 220                 


Thr Tyr Thr His Ala Asn His Ser Cys Ser Gln Gln Thr Lys Ala Ala 
225                 230                 235                 240 


Leu Gln Gln Arg Glu Gly Glu Ile Ala Lys Trp Met Glu Asn Val Phe 
                245                 250                 255     


Asp Ser Ala Val Arg Met Thr Lys Glu Arg Cys Gly Phe Ser Ala Asp 
            260                 265                 270         


Gln Met Lys Phe Leu Gln Cys Gly Phe Gly Ser Arg Arg Lys Arg Asp 
        275                 280                 285             


Gly Lys Lys Phe Val Leu Asn Asp Gln Phe Phe Phe Ala Leu Thr Arg 
    290                 295                 300                 


Asn Gly Leu Glu Val Thr Pro Ala Gly Arg Leu Phe Leu Cys Cys Cys 
305                 310                 315                 320 


Phe Leu Pro Ser His Tyr Val Trp Asp Phe Leu Gly Arg Val Asn Leu 
                325                 330                 335     


Glu Arg Thr Thr Pro Phe Asp Gln Asn Gln Arg Asp Ile Leu Ser Arg 
            340                 345                 350         


Ala Leu Asn Val Phe His Leu Arg Leu Pro Gln Glu Asn Arg Ile Glu 
        355                 360                 365             


Ser Asp Thr Ser Glu Gly Gly Leu Leu Leu Asp Val Phe Ala Glu Leu 
    370                 375                 380                 


Gly Arg Cys Pro Leu Arg Glu Val Phe Asp His Ile Ser Pro Gln Gly 
385                 390                 395                 400 


Gln Lys Gln Phe Arg Pro Lys Pro Asp Asp Arg Ser Pro Asp Gly Glu 
                405                 410                 415     


Glu Val Leu Leu Ala Arg Tyr Asp Asp Arg Phe Pro Gln Leu Ala Leu 
            420                 425                 430         


Arg Leu Ile Asp Gln Leu Gly Ile Leu Asp Leu Val Asp Lys Asn Gly 
        435                 440                 445             


Asn Lys Lys Glu Gly Ile Arg Phe Gln Gln Arg Leu Gly Ser Phe Arg 
    450                 455                 460                 


Phe Arg Phe Tyr Asp Lys Arg Cys Val Asp Gly Ala Ser Arg Leu Arg 
465                 470                 475                 480 


Thr Leu Gln Lys Glu Ile Asn Gly Phe Gly Lys Trp His Glu Leu Glu 
                485                 490                 495     


Ser Arg Arg Arg Ser Arg Trp Ala Gly Ile Ile Arg Glu Ser Ala Gln 
            500                 505                 510         


Pro Asp Gln Glu Ser Glu Gly Gly Phe Ala Pro Asp Thr Ala Asp Ser 
        515                 520                 525             


Gln Pro Tyr Val Thr Asp Cys Ala Pro Arg Tyr Asn Ile His Asn Asn 
    530                 535                 540                 


Arg Ile Gly Met Thr Trp Gly Leu Asp Asp Gly Leu Phe Leu Pro Asp 
545                 550                 555                 560 


Leu Pro Lys Ala Ala Glu Asn Pro Gly Ser Val Ala Val Glu Gln Pro 
                565                 570                 575     


Val Pro Lys Cys Ser Met Ser Ile Phe Asp Leu Pro Ala Leu Leu Phe 
            580                 585                 590         


Tyr Arg His Leu Ile Phe Lys Lys Gly Asn Ile Ala Asn Leu Ala Thr 
        595                 600                 605             


Pro Ala Lys Val Ile Gln Asp Cys Cys Asn Asn Leu His Glu Leu Phe 
    610                 615                 620                 


Glu Leu Ala Glu Gln Gly Ala Ser Pro Asp Ala Leu Lys Lys Phe Ala 
625                 630                 635                 640 


Val Asp Lys Gly Ile Ala Asp Ser Ser Ile Pro Val Arg Leu Leu Asn 
                645                 650                 655     


Tyr Ile Asn Gly Asn Pro Cys Gly Pro Gln Asp Arg Leu Ala Ala His 
            660                 665                 670         


Ala Ala Gln Val Leu Gln Glu Val Val Glu Leu Cys Glu Asn Arg Leu 
        675                 680                 685             


Asp Gln Leu Lys Glu Ala Gln Lys Cys Asp Ile Lys Tyr Gly Lys Lys 
    690                 695                 700                 


Gly Cys Arg Gln Val Arg Tyr Gly His Met Ala Gln Tyr Leu Gly Lys 
705                 710                 715                 720 


Ser Ile Met Arg Trp Gln Pro Pro Arg Pro Gly Gly Gln Asn Lys Leu 
                725                 730                 735     


Thr Gly Leu Asn Tyr Gln Thr Leu Val Lys Ala Leu Ala Thr Ser Gly 
            740                 745                 750         


Gln Ser Trp Asn Asp Arg Glu Val Asn Gln Leu Phe Gln Lys Ser Glu 
        755                 760                 765             


Leu Leu Gly Ser Asp His Pro His Pro Phe Leu Ala Glu Ala Leu Arg 
    770                 775                 780                 


Gly Thr Gln Asn Leu Gly His Phe Tyr Ser Arg Tyr Leu Ala Arg Glu 
785                 790                 795                 800 


Lys Thr Phe Ala Leu Lys Met Lys Ala Glu Leu Glu Ala Arg Pro Ala 
                805                 810                 815     


Glu Ala Leu Arg Gln Val Pro Phe Ala Lys Pro Asp Ala Ala Lys Trp 
            820                 825                 830         


Lys Asp Cys Gln Ser His Pro Asp Tyr Ile Lys Asp Tyr Ala Arg Arg 
        835                 840                 845             


Leu Leu His Thr Pro Ala Gly Gly Lys Glu Thr Pro Ala Ile Leu Leu 
    850                 855                 860                 


Leu Pro Asp Gly Leu Phe Asp Ala His Val Arg Lys Ala Ile Thr Ala 
865                 870                 875                 880 


Phe Leu Pro Asn Thr Glu Leu Cys Gln Met Ala Asn Glu Lys Val Pro 
                885                 890                 895     


Gly Asn Asn Glu Lys Val Pro Gly Asn Glu Cys Cys Tyr Lys Tyr Gly 
            900                 905                 910         


Ile Ser Lys Leu Ile Ala Gln Tyr Phe Glu Gln Val Gln Asn Asp Tyr 
        915                 920                 925             


Ala Gln Pro Phe Tyr Asn Ala Asp Met Pro Asp Phe Gly Arg Ala Tyr 
    930                 935                 940                 


Ser Leu Thr Thr Lys Leu Tyr Gly Gln Lys Val Gly Asn Ser His Gln 
945                 950                 955                 960 


Pro Tyr Tyr Met Asn Ser Ala Asn Leu Lys Thr Ala Val Ala Lys Cys 
                965                 970                 975     


Gly Ala Glu Thr Val Arg Arg Ala Val Asp Met Lys Ala Ala Gln Thr 
            980                 985                 990         


Glu Glu Ser Ala Lys Arg Lys Leu  Arg Ser Ile Leu Asn  Asn Glu Lys 
        995                 1000                 1005             


Ala Ile  Arg Arg Leu Met Thr  Gln Asp Lys Val Leu  Phe Leu Thr 
    1010                 1015                 1020             


Ala Lys  Glu Leu Leu Tyr Ser  Leu Leu Thr His Glu  Trp Phe Asn 
    1025                 1030                 1035             


Tyr Tyr  Thr Lys Pro Ala Asn  Thr Ser Val Leu Gln  Gln Ile Asn 
    1040                 1045                 1050             


Ser Val  Gln Leu Gln Ser Ala  Asp Ser Asp Phe Leu  Arg Gln Cys 
    1055                 1060                 1065             


Ser Gln  Ile Ile Gly Asp Asp  Gln Leu Pro Thr Phe  Arg Phe Lys 
    1070                 1075                 1080             


Leu Lys  Asn Ser Asp Val Thr  Ile Thr Gln Glu Asn  Leu Ser Leu 
    1085                 1090                 1095             


Arg Asn  Met Gly Asn Val Tyr  Arg Val Gln Arg Asp  Pro Arg Trp 
    1100                 1105                 1110             


Gln Thr  Leu Gln Lys Leu Leu  Glu Lys Leu Glu Gln  Thr Glu Val 
    1115                 1120                 1125             


Gln Tyr  Gly Ala Ile Thr Ala  Glu Phe Lys Asn His  Glu Glu Asn 
    1130                 1135                 1140             


Ser Val  Lys Ala Val Glu Leu  Ser Gln Arg Leu Glu  His Glu Ala 
    1145                 1150                 1155             


Tyr Ser  Asp Ala Ile Gly Arg  Gly Glu Thr Ile Asp  Glu Glu Thr 
    1160                 1165                 1170             


Ser His  Asn Phe Arg Lys Leu  Leu Val Cys His Pro  Thr Leu Ser 
    1175                 1180                 1185             


Lys Tyr  Gln Cys Asp Glu Ile  Val Leu Val Arg Asn  Lys Phe Asn 
    1190                 1195                 1200             


His Asn  Gln Tyr Val Asp Pro  Ser Ile Ser Lys Asp  Lys Ile Phe 
    1205                 1210                 1215             


Ile Glu  Arg Asn Met Asn Gly  Lys Lys Val Pro Asn  Leu Ala Lys 
    1220                 1225                 1230             


Ala Met  Tyr Glu Thr Met Lys  Glu Ala Val Glu His  Pro Glu Asp 
    1235                 1240                 1245             


Ile Ile  Arg Lys Glu Val Gly  Glu Val Ser Gly Gly  
    1250                 1255                 1260 


<210>  2239
<211>  1129
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2239

Met Glu Thr Asn Gln Gln Thr His Glu Asn Arg Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Asn Asn His Ile Ala Thr Asp Phe Lys Gln Ala Thr 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ala Ala Phe Leu Cys Asn Lys Thr 
    50                  55                  60                  


Ile Lys Asn Leu Asn Trp Asn His Val His Thr Arg Ala Val Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ser Glu Ser Leu Pro Lys Asp Glu 
                85                  90                  95      


Arg Glu Asn Ser Asp Thr Glu Gly Lys Asp Phe Ala Ser Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Ser Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gln Asp Ser Arg Lys Leu Thr Val 
    130                 135                 140                 


Ser Pro Glu Leu Ala Asn Phe Leu Thr Val Asn Phe Gln Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Ala Arg Met Lys Asp Val Leu Thr Asp Ala Asp Tyr 
                165                 170                 175     


Ala Leu Val Glu Asn Leu Gln Met Val Ala Pro Asp Asn Lys Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ala Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Thr Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asn Leu Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Ser 
            260                 265                 270         


Val Ile Thr Asp Lys Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Asp Asp Glu Arg 
    290                 295                 300                 


Glu Arg Ile Leu Asp Glu Ile Asp Tyr Gln Asp Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg Tyr Ser Asn Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Asp Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Asn Tyr Thr Lys Gln Phe Ala Gly Glu 
        355                 360                 365             


Gln Ala Glu Arg Lys Val Leu Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asp Pro Glu Leu Ile Gln Gln Arg Ile Asp Lys Gln 
385                 390                 395                 400 


Gln His Thr Ala Gly Phe Asp Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Thr Lys Glu Asn Ile Ala Thr Leu Ile 
            420                 425                 430         


Ala Lys Ser Lys Ala Ser Ser Lys Val Glu His Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Gln Ala Glu Glu Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Ile Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Ser Gln Leu Pro Ala Asp Trp Asp Glu Phe Ser Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asp Ser Thr Leu Lys Tyr Leu 
        515                 520                 525             


Arg Gln Arg Lys Thr Thr Leu Asn Thr Ile Leu Ser Lys Ser Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Lys Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Thr Arg Leu Lys Ala Val Glu Lys His Lys Leu 
            580                 585                 590         


Asn Lys Ser Val Lys Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Glu Glu Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Ala Asn Ala Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Asn Asp Gly His Pro Phe Leu Gln Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Gln Ala Tyr Leu Ile 
        675                 680                 685             


Glu Lys Gly Asn Lys Met Val Pro Arg Leu Asn Pro Lys Thr Asn Lys 
    690                 695                 700                 


Thr Ser Lys Val Asp Glu Ser Trp Met Met Lys Gln Phe Tyr Val Lys 
705                 710                 715                 720 


Glu Trp Lys Glu Glu Ile Ala Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Ser Arg Ile Pro Phe Thr Ile Arg Gln Trp Asp Glu Lys 
            740                 745                 750         


Glu Lys Tyr Asp Leu Asn Thr Trp Leu Arg His Val Thr Val Gly Lys 
        755                 760                 765             


Asn Asn Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe Asp 
    770                 775                 780                 


Glu Ala Leu Cys Asp Leu Leu Arg Glu Gln Leu Asp Thr Lys Ile Val 
785                 790                 795                 800 


Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Ile Trp Trp 
                805                 810                 815     


Lys Thr Arg Asn Asp Asp Thr Gln Gln Phe Tyr Gln Ser Glu Arg Glu 
            820                 825                 830         


Tyr Asn Ile Tyr Asn Glu Lys Val Arg Phe Lys Ile Asp Ser Ser Ala 
        835                 840                 845             


His Phe Ala Asp Tyr Tyr Lys Asn Ala Leu Ser Arg Ala Phe Thr Arg 
    850                 855                 860                 


Leu Lys Ala Glu Arg Glu Thr Ala Arg Gln Ser Asn Lys Arg Leu Pro 
865                 870                 875                 880 


Pro Leu Glu Tyr Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile Ala 
                885                 890                 895     


Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met Ala 
            900                 905                 910         


Val Leu Met Leu Glu Arg Leu Met Asp Asn Ser Pro Asn Leu Arg Leu 
        915                 920                 925             


Ser Lys Ile Glu Thr Leu Leu Asn Asp Thr Thr Pro Ile Arg Glu Lys 
    930                 935                 940                 


Ile Ser Ala Thr Leu Ser Phe Asp Ala Ser Gly Glu Arg Ile Ser Gly 
945                 950                 955                 960 


Lys Ser Asn Pro Thr Val Thr Lys Thr Leu Val Ala Glu Arg Lys Gln 
                965                 970                 975     


Lys Asn Tyr Thr Glu Leu Arg Lys Tyr Arg Tyr Asp Arg Arg Leu Pro 
            980                 985                 990         


Glu Leu Phe Glu Tyr Val Gln Ala  Asp Glu Ile Pro Leu  Glu Trp Leu 
        995                 1000                 1005             


Leu Glu  Glu Leu Ser Ala Tyr  Asn Asn Ala Lys Gln  Gln Val Phe 
    1010                 1015                 1020             


Asp Thr  Val Phe Thr Leu Glu  Lys Lys Ile Ile Gly  Thr Asp Pro 
    1025                 1030                 1035             


Asp Gly  Leu Lys Ser Leu Phe  Thr Gly Ala Asn Gly  Glu Leu Gln 
    1040                 1045                 1050             


Thr Gly  Asn Ile Gln His Lys  Pro Tyr Val Gln Trp  Leu Thr Asn 
    1055                 1060                 1065             


Lys Gly  Leu Ile Asn Lys Glu  Glu Lys Gln Phe Ile  Asn Met Val 
    1070                 1075                 1080             


Arg Lys  Cys Phe Ser His Asn  Gln Phe Pro Gln Arg  Lys Thr Met 
    1085                 1090                 1095             


Glu Leu  Leu Ile Pro Ala Trp  Asn Glu Lys Lys Leu  Ala Leu Gln 
    1100                 1105                 1110             


Ile Ala  Thr Val Tyr Asn Gln  Leu Ile Ala Asp Leu  Thr Asn Lys 
    1115                 1120                 1125             


Ile 
    


<210>  2240
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2240

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2241
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2241

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Val Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Ser Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2242
<211>  1118
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2242

Met Lys Glu Glu Glu Thr Pro Val Val Ser Thr Tyr Asn Lys Asp Asp 
1               5                   10                  15      


Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val Tyr 
            20                  25                  30          


Ile Thr Ile Asn His Ile Asn Lys Leu Leu Glu Ile Arg Glu Ile Asp 
        35                  40                  45              


Asn Asp Glu Lys Ile Leu Asp Ile Lys Ala Leu Trp Gln Lys Val Asn 
    50                  55                  60                  


Lys Asp Leu Asn Gln Lys Ala Arg Leu Arg Glu Leu Met Thr Lys His 
65                  70                  75                  80  


Phe Pro Phe Leu Glu Thr Ala Ile Tyr Thr Lys Asn Lys Glu Asp Lys 
                85                  90                  95      


Lys Glu Val Lys Glu Glu Lys Gln Ala Lys Ala Gln Ser Phe Asp Ser 
            100                 105                 110         


Leu Asn His Cys Leu Phe Leu Phe Leu Glu Lys Leu Gln Glu Ala Arg 
        115                 120                 125             


Asn Tyr Tyr Ser His Tyr Lys Tyr Ser Glu Ser Thr Lys Glu Pro Val 
    130                 135                 140                 


Leu Glu Lys Glu Leu Leu Lys Lys Met Tyr Asn Ile Phe Asp Asn Asn 
145                 150                 155                 160 


Ile Gln Leu Val Ile Lys Asp Tyr Gln His Asn Lys Asp Ile Asn Pro 
                165                 170                 175     


Asp Glu Asp Phe Lys His Leu Asp Arg Thr Glu Lys Glu Phe Asn Tyr 
            180                 185                 190         


Tyr Phe Thr Gln Asp Lys Lys Gly Lys Ile Thr Glu Ser Gly Leu Leu 
        195                 200                 205             


Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Met Gln 
    210                 215                 220                 


Gln Lys Phe Thr Gly Phe Lys Asp Asn Arg Glu Asn Asn Lys Gln Met 
225                 230                 235                 240 


Thr His Glu Val Phe Cys Arg Ser Arg Met Leu Leu Pro Lys Leu Arg 
                245                 250                 255     


Leu Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu Asn 
            260                 265                 270         


Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Lys Gly Glu 
        275                 280                 285             


Asp Arg Lys Lys Phe Glu Val Pro Phe Asp Ser Thr Asp Glu Asp Tyr 
    290                 295                 300                 


Asp Ala Glu Gln Asp Pro Phe Lys Asn Thr Leu Ile Arg His Gln Asp 
305                 310                 315                 320 


Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe Asp Tyr Asn Glu Ile Phe 
                325                 330                 335     


Lys Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile 
            340                 345                 350         


Tyr Lys Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg His Leu Thr His 
        355                 360                 365             


Lys Leu Tyr Gly Phe Glu Arg Leu Gln Glu Phe Thr Lys Gln His Arg 
    370                 375                 380                 


Pro Asp Asp Trp Lys Ala Ile Val Lys Asp Phe Asp Thr Tyr Glu Thr 
385                 390                 395                 400 


Ser Glu Glu Pro Tyr Ile Ser Glu Thr Thr Pro His Tyr His Leu Glu 
                405                 410                 415     


Asn Gln Lys Ile Gly Ile Arg Phe Lys Asn Asp Asn Asp Lys Ile Trp 
            420                 425                 430         


Pro Ser Leu Glu Thr Asn Gly Glu Asn Asn Glu Lys Ser Lys Tyr Lys 
        435                 440                 445             


Leu Asp Lys Gln Tyr Gln Ala Glu Ala Phe Leu Ser Val His Glu Leu 
    450                 455                 460                 


Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Lys Lys Glu Glu Pro Asn 
465                 470                 475                 480 


Asn Asp Lys Lys Asn Ala Ser Arg Val Glu Gly Phe Ile Lys Arg Glu 
                485                 490                 495     


Ile Arg Asp Ile Phe Lys Leu Tyr Asp Ala Phe Ala Asn Asp Glu Ile 
            500                 505                 510         


Asn Asn Ile Asp Asp Leu Lys Lys Tyr Tyr Lys Asp Lys Asn Val Glu 
        515                 520                 525             


Ile Arg His Leu Pro Lys Gln Met Ile Ala Ile Leu Glu Ser Lys Pro 
    530                 535                 540                 


Lys Asp Met Ala Lys Glu Ala Lys Arg Lys Gln Lys Glu Met Val Lys 
545                 550                 555                 560 


Asp Thr Lys Lys Leu Leu Ala Thr Leu Glu Lys Gln Thr Gln Lys Glu 
                565                 570                 575     


Lys Glu Asp Asn Gly Arg Asn Val Lys Leu Leu Lys Ser Gly Glu Ile 
            580                 585                 590         


Ala Arg Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln Lys 
        595                 600                 605             


Asp Asn Glu Gly Asn Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu 
    610                 615                 620                 


Tyr Gln Met Leu Gln Arg Ser Leu Ala Leu Tyr Asn Lys Glu Glu Lys 
625                 630                 635                 640 


Pro Thr Arg Tyr Phe Arg Gln Val Asn Leu Ile Glu Ser Ser Asn Pro 
                645                 650                 655     


His Pro Phe Leu Lys Trp Thr Lys Trp Glu Glu Cys Asn Asn Ile Leu 
            660                 665                 670         


Thr Phe Tyr His Arg Tyr Leu Thr Lys Lys Ile Glu Phe Leu Asn Lys 
        675                 680                 685             


Leu Lys Pro Glu Asp Trp Lys Lys Asn Gln Tyr Phe Leu Lys Val Lys 
    690                 695                 700                 


Glu Pro Lys Thr Asn Arg Glu Thr Leu Val Gln Gly Trp Lys Asn Gly 
705                 710                 715                 720 


Phe Asn Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg Glu Trp Phe 
                725                 730                 735     


Glu Arg His Gln Asn Asp Ser Glu Glu Tyr Lys Lys Val Glu Ala Leu 
            740                 745                 750         


Gly Arg Val Gly Leu Val Thr Lys Val Ile Pro Leu Phe Phe Lys Lys 
        755                 760                 765             


Glu Tyr Phe Lys Glu Asp Ala Arg Lys Glu Ile Asn Asp Cys Val Gln 
    770                 775                 780                 


Pro Phe Tyr Asn Phe Pro Tyr Asn Val Gly Asn Ile Tyr Arg Leu Lys 
785                 790                 795                 800 


Asp Glu Asp Phe Leu His Arg Glu Glu Arg Ile Lys Leu Trp Asn Asn 
                805                 810                 815     


Lys Lys Asp Lys Phe Lys Gly Tyr Lys Glu Lys Ile Lys Ser Lys Lys 
            820                 825                 830         


Leu Thr Glu Lys Glu Lys Glu Glu Phe Arg Ser Tyr Leu Glu Phe Gln 
        835                 840                 845             


Ser Trp Asn Asn Phe Glu Arg Glu Leu Arg Leu Val Arg Asn Gln Asp 
    850                 855                 860                 


Ile Val Thr Trp Leu Leu Cys Lys Glu Leu Ile Asp Lys Leu Lys Ile 
865                 870                 875                 880 


Asp Glu Leu Asn Ile Glu Glu Leu Lys Lys Leu Arg Leu Asn Asn Ile 
                885                 890                 895     


Asp Thr Asp Thr Ala Lys Lys Glu Lys Asn Asn Ile Leu Asn Arg Val 
            900                 905                 910         


Met Pro Met Glu Leu Leu Val Met Val Tyr Glu Val Asn Lys Ala Gly 
        915                 920                 925             


Asn Ile Ile Lys Asn Lys Pro Leu His Thr Ile Tyr Ile Lys Glu Ala 
    930                 935                 940                 


Lys Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys Asp 
945                 950                 955                 960 


Arg Arg Leu Asn Gly Leu Phe Ser Phe Val Lys Thr Asn Ser Glu Ala 
                965                 970                 975     


Glu Ser Lys Arg Asn Pro Ile Ser Lys Leu Leu Val Glu Tyr Glu Leu 
            980                 985                 990         


Gly Glu Tyr Gln Glu Ala Arg Ile  Glu Ile Ile Lys Asp  Met Leu Ala 
        995                 1000                 1005             


Leu Glu  Glu Thr Leu Ile Asn  Lys Tyr Lys Asp Leu  Pro Thr Asn 
    1010                 1015                 1020             


Lys Phe  Ser Asp Met Leu Asn  Ser Trp Leu Glu Gly  Lys Asp Glu 
    1025                 1030                 1035             


Ala Asp  Lys Ala Arg Phe Gln  Asn Asp Val Asp Phe  Leu Ile Ala 
    1040                 1045                 1050             


Val Arg  Asn Ala Phe Ser His  Asn Gln Tyr Pro Met  His Asn Lys 
    1055                 1060                 1065             


Ile Glu  Phe Ala Asn Ile Lys  Pro Phe Ser Leu Tyr  Thr Met Asn 
    1070                 1075                 1080             


Asn Ser  Glu Glu Lys Gly Leu  Gly Ile Ala Asn Gln  Leu Lys Asp 
    1085                 1090                 1095             


Lys Thr  Lys Glu Thr Lys Asp  Lys Ile Ile Glu Ile  Glu Lys Pro 
    1100                 1105                 1110             


Ile Glu  Thr Lys Glu 
    1115             


<210>  2243
<211>  1118
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2243

Met Lys Glu Glu Glu Thr Pro Val Val Ser Thr Tyr Asn Lys Asp Asp 
1               5                   10                  15      


Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val Tyr 
            20                  25                  30          


Ile Thr Ile Asn His Ile Asn Lys Leu Leu Glu Ile Arg Glu Ile Asp 
        35                  40                  45              


Asn Asp Glu Lys Ile Leu Asp Ile Lys Ala Leu Trp Gln Lys Val Asn 
    50                  55                  60                  


Lys Asp Leu Asn Gln Lys Ala Arg Leu Arg Glu Leu Met Thr Lys His 
65                  70                  75                  80  


Phe Pro Phe Leu Glu Thr Ala Ile Tyr Thr Lys Asn Lys Glu Asp Lys 
                85                  90                  95      


Lys Glu Val Lys Glu Glu Lys Gln Ala Lys Ala Gln Ser Phe Asp Ser 
            100                 105                 110         


Leu Asn His Cys Leu Phe Leu Phe Leu Glu Lys Leu Gln Glu Ala Arg 
        115                 120                 125             


Asn Tyr Tyr Ser His Tyr Lys Tyr Ser Glu Ser Thr Lys Glu Pro Val 
    130                 135                 140                 


Leu Glu Lys Glu Leu Leu Lys Lys Met Tyr Asn Ile Phe Asp Asn Asn 
145                 150                 155                 160 


Ile Gln Leu Val Ile Lys Asp Tyr Gln His Asn Lys Asp Ile Asn Pro 
                165                 170                 175     


Asp Glu Asp Phe Lys His Leu Asp Arg Thr Glu Lys Glu Phe Asn Tyr 
            180                 185                 190         


Tyr Phe Thr Gln Asp Lys Lys Gly Lys Ile Thr Glu Ser Gly Leu Leu 
        195                 200                 205             


Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Met Gln 
    210                 215                 220                 


Gln Lys Phe Thr Gly Phe Lys Asp Asn Arg Glu Asn Asn Lys Gln Met 
225                 230                 235                 240 


Thr His Glu Val Phe Cys Arg Ser Arg Met Leu Leu Pro Lys Leu Arg 
                245                 250                 255     


Leu Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu Asn 
            260                 265                 270         


Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Lys Gly Glu 
        275                 280                 285             


Asp Arg Lys Lys Phe Glu Val Pro Phe Asp Ser Thr Asp Glu Asp Tyr 
    290                 295                 300                 


Asp Ala Glu Gln Asp Pro Phe Lys Asn Thr Leu Ile Arg His Gln Asp 
305                 310                 315                 320 


Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe Asp Tyr Asn Glu Ile Phe 
                325                 330                 335     


Lys Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile 
            340                 345                 350         


Tyr Lys Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg His Leu Thr His 
        355                 360                 365             


Lys Leu Tyr Gly Phe Glu Arg Leu Gln Glu Phe Thr Lys Gln His Arg 
    370                 375                 380                 


Pro Asp Asp Trp Lys Ala Ile Val Lys Asp Phe Asp Thr Tyr Glu Thr 
385                 390                 395                 400 


Ser Glu Glu Pro Tyr Ile Ser Glu Thr Thr Pro His Tyr His Leu Glu 
                405                 410                 415     


Asn Gln Lys Ile Gly Ile Arg Phe Lys Asn Asp Asn Asp Lys Ile Trp 
            420                 425                 430         


Pro Ser Leu Glu Thr Asn Gly Glu Asn Asn Glu Lys Ser Lys Tyr Lys 
        435                 440                 445             


Leu Asp Lys Gln Tyr Gln Ala Glu Ala Phe Leu Ser Val His Glu Leu 
    450                 455                 460                 


Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Lys Lys Glu Glu Pro Asn 
465                 470                 475                 480 


Asn Asp Lys Lys Asn Ala Ser Arg Val Glu Gly Phe Ile Lys Arg Glu 
                485                 490                 495     


Ile Arg Asp Ile Phe Lys Leu Tyr Asp Ala Phe Ala Asn Asp Glu Ile 
            500                 505                 510         


Asn Asn Ile Asp Asp Leu Lys Lys Tyr Tyr Lys Asp Lys Asn Val Glu 
        515                 520                 525             


Ile Arg His Leu Pro Lys Gln Met Ile Ala Ile Leu Glu Ser Lys Pro 
    530                 535                 540                 


Lys Asp Met Ala Lys Glu Ala Lys Arg Lys Gln Lys Glu Met Val Lys 
545                 550                 555                 560 


Asp Thr Lys Lys Leu Leu Ala Thr Leu Glu Lys Gln Thr Gln Lys Glu 
                565                 570                 575     


Lys Glu Asp Asn Gly Arg Asn Val Lys Leu Leu Lys Ser Gly Glu Ile 
            580                 585                 590         


Ala Arg Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln Lys 
        595                 600                 605             


Asp Asn Glu Gly Asn Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu 
    610                 615                 620                 


Tyr Gln Met Leu Gln Arg Ser Leu Ala Leu Tyr Asn Lys Glu Glu Lys 
625                 630                 635                 640 


Pro Thr Arg Tyr Phe Arg Gln Val Asn Leu Ile Glu Ser Ser Asn Pro 
                645                 650                 655     


His Pro Phe Leu Lys Trp Thr Lys Trp Glu Glu Cys Asn Asn Ile Leu 
            660                 665                 670         


Thr Phe Tyr His Arg Tyr Leu Thr Lys Lys Ile Glu Phe Leu Asn Lys 
        675                 680                 685             


Leu Lys Pro Glu Asp Trp Lys Lys Asn Gln Tyr Phe Leu Lys Val Lys 
    690                 695                 700                 


Glu Pro Lys Thr Asn Arg Glu Thr Leu Val Gln Gly Trp Lys Asn Gly 
705                 710                 715                 720 


Phe Asn Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg Glu Trp Phe 
                725                 730                 735     


Glu Arg His Gln Asn Asp Ser Glu Glu Tyr Lys Lys Val Glu Ala Leu 
            740                 745                 750         


Gly Arg Val Gly Leu Val Thr Lys Val Ile Pro Leu Phe Phe Lys Lys 
        755                 760                 765             


Glu Tyr Phe Lys Glu Asp Ala Arg Lys Glu Ile Asn Asp Cys Val Gln 
    770                 775                 780                 


Pro Phe Tyr Asn Phe Pro Tyr Asn Val Gly Asn Ile Tyr Arg Leu Lys 
785                 790                 795                 800 


Asp Glu Asp Phe Leu His Arg Glu Glu Arg Ile Lys Leu Trp Asn Asn 
                805                 810                 815     


Lys Lys Asp Lys Phe Lys Gly Tyr Lys Glu Lys Ile Lys Ser Lys Lys 
            820                 825                 830         


Leu Thr Glu Lys Glu Lys Glu Glu Phe Arg Ser Tyr Leu Glu Phe Gln 
        835                 840                 845             


Ser Trp Asn Asn Phe Glu Arg Glu Leu Arg Leu Val Arg Asn Gln Asp 
    850                 855                 860                 


Ile Val Thr Trp Leu Leu Cys Lys Glu Leu Ile Asp Lys Leu Lys Ile 
865                 870                 875                 880 


Asp Glu Leu Asn Ile Glu Glu Leu Lys Lys Leu Arg Leu Asn Asn Ile 
                885                 890                 895     


Asp Thr Asp Thr Ala Lys Lys Glu Lys Asn Asn Ile Leu Asn Arg Val 
            900                 905                 910         


Met Pro Met Glu Leu Leu Val Met Val Tyr Glu Val Asn Lys Ala Gly 
        915                 920                 925             


Asn Ile Ile Lys Asn Lys Pro Leu His Thr Ile Tyr Ile Lys Glu Ala 
    930                 935                 940                 


Lys Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys Asp 
945                 950                 955                 960 


Arg Arg Leu Asn Gly Leu Phe Ser Phe Val Lys Thr Asn Ser Glu Ala 
                965                 970                 975     


Glu Ser Lys Arg Asn Pro Ile Ser Lys Leu Leu Val Glu Tyr Glu Leu 
            980                 985                 990         


Gly Glu Tyr Gln Glu Ala Arg Ile  Glu Ile Ile Lys Asp  Met Leu Ala 
        995                 1000                 1005             


Leu Glu  Glu Thr Leu Ile Asn  Lys Tyr Lys Asp Leu  Pro Thr Asn 
    1010                 1015                 1020             


Lys Phe  Ser Asp Met Leu Asn  Ser Trp Leu Glu Gly  Lys Asp Glu 
    1025                 1030                 1035             


Ala Asp  Lys Ala Arg Phe Gln  Asn Asp Val Asp Phe  Leu Ile Ala 
    1040                 1045                 1050             


Val Arg  Asn Ala Phe Ser His  Asn Gln Tyr Pro Met  His Asn Lys 
    1055                 1060                 1065             


Ile Glu  Phe Ala Asn Ile Lys  Pro Phe Ser Leu Tyr  Thr Met Asn 
    1070                 1075                 1080             


Asn Ser  Glu Glu Lys Gly Leu  Gly Ile Ala Asn Gln  Leu Lys Asp 
    1085                 1090                 1095             


Lys Thr  Lys Glu Thr Lys Asp  Lys Ile Ile Glu Ile  Glu Lys Pro 
    1100                 1105                 1110             


Ile Glu  Thr Lys Glu 
    1115             


<210>  2244
<211>  1253
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2244

Met Leu Glu Ile Gln Ile Glu Lys Glu Lys Arg Gly Trp Phe Trp Ala 
1               5                   10                  15      


Met Asn Leu Thr Met Ala Leu Asn Asn Leu Glu Thr Ile Ala Lys Arg 
            20                  25                  30          


Ala Leu Asn Val Leu Gly Lys Pro Tyr Pro Ala Ser Gln Ser Glu Asp 
        35                  40                  45              


Glu Gln Thr Asn Ala Leu Lys Gln Ala Leu Asp Glu Leu Gln Lys Gln 
    50                  55                  60                  


Pro Leu Ile Cys Gln Thr Lys Ile Glu Arg Val Phe Phe Arg Ser Leu 
65                  70                  75                  80  


Pro His Leu Asn Lys Phe Arg Gln Phe Ile Glu Met Gly Gly Glu Lys 
                85                  90                  95      


Ser Ser Ala Ser Tyr Val Glu Lys Ser Ser Ser Arg Ala Asp Ala Glu 
            100                 105                 110         


Ala Thr Gln Arg Gln Ser Gly Arg Asp Phe Thr Ser Asp Asp Leu Phe 
        115                 120                 125             


Gln Leu Ala Arg Tyr Tyr Leu Lys Ser Leu Val Glu Leu Arg Asn Tyr 
    130                 135                 140                 


Phe Ala His Ser Glu His Gln Tyr Pro Lys Leu Pro Glu Ser Leu Asp 
145                 150                 155                 160 


Ile Lys Gly Val Arg Phe Pro Ser Ser Phe Glu Asn Ala Leu Phe Asn 
                165                 170                 175     


Ala Asn Val Arg Thr Val Lys Asp Arg Phe Tyr Lys Asp Asp Arg Lys 
            180                 185                 190         


Asp Ala Arg Glu Ile Glu Asn Gly Phe Leu Cys Phe Arg Pro Lys Lys 
        195                 200                 205             


Thr Val Lys Asn Arg Glu Thr Val Asp Asn Pro Glu Phe Lys Phe Arg 
    210                 215                 220                 


Leu Thr Glu Arg Asn Asp Ala Asn Gly Arg Arg Tyr Pro Thr Gln Ala 
225                 230                 235                 240 


Gly Leu Ala Phe Phe Val Ala Arg Phe Leu Glu Lys Arg Tyr Val Asp 
                245                 250                 255     


Leu Leu Phe Glu Thr Thr Asp Ala Asn Gly Val Pro Val Leu Pro Leu 
            260                 265                 270         


His Arg Pro Gln Asp Val Asp Gly Val Glu Phe Ser Leu Ala Pro Arg 
        275                 280                 285             


Arg Val Tyr Gly Leu Asn Ala Ala Arg Leu Pro Arg Arg Arg Val Glu 
    290                 295                 300                 


Thr Thr Ala Arg Pro Glu Ser Ser Asn Glu Thr Leu Gly Leu Asp Leu 
305                 310                 315                 320 


Ile Gly Tyr Leu Ala Arg Cys Pro Lys Arg Val Tyr Glu Phe Leu Ser 
                325                 330                 335     


Glu Thr Asp Arg Arg Lys Phe Arg Val Ala Ala Asp Glu Ser Asn Pro 
            340                 345                 350         


Ser Glu Gly Leu Arg Thr Arg Ser Glu Lys Arg Phe Ala Arg Leu Ala 
        355                 360                 365             


Ala Leu Cys Leu Asp Arg Met Asn Cys Phe Glu Asn Leu Arg Phe Gln 
    370                 375                 380                 


Val Asp Met Gly Gln Tyr Tyr Ser Ala Thr His Arg Arg Arg Leu Ile 
385                 390                 395                 400 


Asp Gly Thr Thr Ile Asp Asp Arg Arg Val Gly Lys Arg Val Phe Trp 
                405                 410                 415     


Phe Glu Arg Ile Gln Asn Ala Val Asp Tyr Tyr Arg Ala Glu Arg Leu 
            420                 425                 430         


Lys Pro Glu Ser Lys Tyr Phe Val Pro Thr Asp Glu Ala Glu Thr Pro 
        435                 440                 445             


Pro Glu Thr Asp Tyr Arg Val Asp Ala Tyr Pro Arg Tyr Arg Val Lys 
    450                 455                 460                 


Asn Gln Gln Leu Gly Leu Arg Leu Val Asp Ala Ser Gln Lys Asn Ala 
465                 470                 475                 480 


Pro Pro Lys Leu Ile Pro Trp Thr His Ser Ala Lys Arg Gly Ser Ala 
                485                 490                 495     


Pro Lys Thr Arg Met Lys Arg Pro Glu Phe Trp Leu Ser Gln Tyr Glu 
            500                 505                 510         


Leu Pro Ala Leu Leu Phe Val Ala Leu His Gly Lys Ala Gln Asp Ala 
        515                 520                 525             


Gln Asn Val Ile Ala Asp Tyr Gln Lys Asn Trp Arg Arg Phe Leu Glu 
    530                 535                 540                 


Asp Val Arg Asp Gly Lys Phe Asp Phe Gly Gly Gly Arg Ala Leu Arg 
545                 550                 555                 560 


Glu Thr Arg Gln Thr Phe Glu Ser Gln Tyr Gly Leu Arg Phe Asp Asp 
                565                 570                 575     


Leu Pro Asp Ser Thr Arg Ala Leu Phe Arg Ser Thr Ala Ser Asp Ser 
            580                 585                 590         


Lys Glu Leu Glu Lys Lys Arg Val Asp Ala Ala Glu Gln Thr Leu Pro 
        595                 600                 605             


Glu Arg Gln Ile Asp Arg Leu Leu Asp Glu Thr Arg Arg Arg Leu Ala 
    610                 615                 620                 


Val Leu Glu Ser Glu Thr Arg Glu Val Phe Gln Leu Gly Lys Arg Lys 
625                 630                 635                 640 


Arg Pro Ser Leu Ser Val Gly Arg Val Ala Ser Cys Leu Val Arg Asp 
                645                 650                 655     


Leu Met Arg Phe Gln Tyr Ala Thr Ser Glu Lys Ser Phe Gly Lys Ile 
            660                 665                 670         


Pro Ser Ser Pro Asp Phe Ile Ala Leu Gln Thr Ser Leu Ala Cys Phe 
        675                 680                 685             


Glu Ser Arg Gln Asn Glu Leu Leu Glu Ile Phe Lys Ala Ala Lys Leu 
    690                 695                 700                 


Ile Pro Ser Asn Phe Val Ala Pro Asn Asp Ala Glu Glu Ala Phe Phe 
705                 710                 715                 720 


Phe Ala Asp Ala Gln Asn Ala Glu Arg Ser Leu His Pro Phe Leu Gly 
                725                 730                 735     


Ala Val Val Ala Asp Ala Ala Asn Leu Arg Asp Trp Lys Ser Phe Tyr 
            740                 745                 750         


Arg Ala Tyr Leu Thr Cys Arg Leu Asn Trp Leu Arg Gly Cys Ala Pro 
        755                 760                 765             


Gln Glu Leu Arg His Thr Arg Tyr Gly Asn Arg Arg Leu Glu Lys Leu 
    770                 775                 780                 


Lys Lys Met Arg Lys Ser Gly Lys Arg Gln Thr Val Ala Gln Gln Met 
785                 790                 795                 800 


Ala Thr Arg Leu Leu Glu Gln Pro Ile Asn Leu Pro Arg Gly Leu Phe 
                805                 810                 815     


Thr Asp Leu Val Arg Ala Val Val Gln Glu Arg Phe Gly Asp Gln Leu 
            820                 825                 830         


Ala Lys Ala Thr Gln Asn Gly Ala Thr Ser Thr Asn Ala Ser Trp Leu 
        835                 840                 845             


Ile Gly Lys Val Arg Asp Trp Ser Asp Asp Ala Ser Gln Gly Phe Tyr 
    850                 855                 860                 


Ser Trp Arg Arg Asp Tyr Arg Asn Val Ala Ser Phe Lys Arg Leu Phe 
865                 870                 875                 880 


Glu Leu Cys Gly Pro Thr Val Ser Thr Ser Pro Leu Ala Phe Arg Ala 
                885                 890                 895     


Leu Asn Ser Thr Ser Pro Leu Asp Phe Arg Ala Leu Lys Glu Ala Phe 
            900                 905                 910         


Asp Ala Asn Phe Asp Ala Asn Tyr Ala Ala Ala Glu Phe Ala Lys Thr 
        915                 920                 925             


Asp His Lys Thr Asp Arg Glu Asp Trp Glu Arg Phe Ile Arg Glu Ala 
    930                 935                 940                 


Glu Ala Glu Leu Arg Glu Glu Ala Leu Glu Ala Thr Arg Gly Arg Ser 
945                 950                 955                 960 


Gln Arg Arg Pro Phe Ile Pro Arg Glu Lys Ile Glu Glu Arg Ala Ser 
                965                 970                 975     


Lys Lys Arg Lys Lys Phe Ala Asp Glu Gln Lys Ala Lys Arg Arg Ala 
            980                 985                 990         


Ala Glu His Ala Lys Ile Arg Arg  Leu Ser Asp Ala Glu  Arg Asp Ile 
        995                 1000                 1005             


Arg His  Ala Glu Ile Gln Asp  Tyr Val Leu Leu Leu  Ala Ala Ser 
    1010                 1015                 1020             


Tyr Phe  Leu Phe Glu Gly Asp  Leu Ala Lys Ile Arg  Leu Ala Asp 
    1025                 1030                 1035             


Val Tyr  Ala Ile Val Asp Asp  Ala Thr Gly Thr Val  Ser Thr Asn 
    1040                 1045                 1050             


Pro Leu  Arg Lys Leu Arg Pro  Cys Glu Val Leu Val  Asp Val Pro 
    1055                 1060                 1065             


Gly Ser  Gly Thr Cys Lys Ile  Arg Gly Glu Met Asn  Val Lys Asn 
    1070                 1075                 1080             


Ser Gly  Asn Phe Gln Arg Phe  Leu Thr Asp Gly Arg  Leu Pro Ser 
    1085                 1090                 1095             


Phe Leu  Arg Ser Leu Arg Leu  Met Gln Ala Glu Asn  Ala Glu Glu 
    1100                 1105                 1110             


Leu Ser  Tyr Ile Asp Leu Ala  Asn Glu Phe Ala Ala  Ser Asp Arg 
    1115                 1120                 1125             


Leu Gln  Arg Gly Arg Ile Phe  Ala Ala Ile Tyr Arg  Phe Glu Asn 
    1130                 1135                 1140             


Ala Cys  Phe Ser Val Phe Pro  Glu Leu Lys Asp Lys  Lys Arg Gly 
    1145                 1150                 1155             


Gly Tyr  Val Ser Phe Ala Thr  Ile Leu Thr Ser Val  Phe Pro Asn 
    1160                 1165                 1170             


Asp Glu  Glu Thr Gln Tyr Arg  Leu Leu Val Ile Arg  Asn Lys Phe 
    1175                 1180                 1185             


Met His  Gln Glu Tyr Pro Ile  Tyr Asp Ala Ser Gln  Thr Lys Asp 
    1190                 1195                 1200             


Lys Gln  Arg Trp Thr Pro Ile  Phe Asp Arg Trp Asn  Arg Glu Met 
    1205                 1210                 1215             


Trp Ala  Lys Tyr Asp Pro Lys  His Gly Arg Ala Leu  Cys Gln Cys 
    1220                 1225                 1230             


Ala Val  Asp Trp Ala Glu Pro  Tyr Phe Asp Glu Ala  Thr Lys Leu 
    1235                 1240                 1245             


Val Glu  Ser Arg Arg 
    1250             


<210>  2245
<211>  1098
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2245

Met Asn Asn Glu Gln Asn Leu Glu Gln Arg Ile Phe Ala Gln Ala Lys 
1               5                   10                  15      


Asn Ile Arg Asp Asp Lys Ala Tyr Phe Gly Ala His Leu Asn Leu Ala 
            20                  25                  30          


Arg His Asn Ala Phe Ile Ile Leu His His Ile Asn Gln Arg Leu Gly 
        35                  40                  45              


Phe Ile Asp Gln Asn Val Gln Asp Asp Ala Gln Phe Lys Lys Phe Lys 
    50                  55                  60                  


Cys Leu Thr Ile Leu Lys Gln Ser Ser Lys Pro Asp Leu Ile Ala Lys 
65                  70                  75                  80  


Ser Leu Asp Leu Ile Arg Phe His Phe Pro Phe Leu Gln Ile Leu Thr 
                85                  90                  95      


Asp Lys Leu Ser Asp Ile Arg Ser Ser Asn Gly Glu Arg Lys Ile Leu 
            100                 105                 110         


Thr Pro Gln Glu Glu Gly Glu Ile Ile Glu Ser Leu Leu Thr Asp Leu 
        115                 120                 125             


Asn Gly Tyr Arg Asn Glu Tyr Cys His Gly Glu Asn Lys Ser His Val 
    130                 135                 140                 


Pro Asp Ser Tyr Leu Ile Lys Asn Leu Lys Ser Ile Tyr Asp Ala Ser 
145                 150                 155                 160 


Leu Arg Met Val Lys Glu Arg Phe Lys Leu Glu Pro His Lys Ile Lys 
                165                 170                 175     


His Leu Glu Arg Asn Asn Lys Asp Gly Glu Lys Leu Asn Phe Lys Tyr 
            180                 185                 190         


Ala Leu Ser Asn Asn Ser Ser Ile Ser Glu Lys Gly Leu Val Phe Phe 
        195                 200                 205             


Ile Asn Leu Phe Leu Glu Val Lys Asp Ser Tyr Ser Phe Ile Lys Lys 
    210                 215                 220                 


Ile Glu Gly Phe Lys Asn Ala Gly Thr Asn Ser Leu Asn Ala Thr Thr 
225                 230                 235                 240 


Tyr Cys Phe Thr Ile Gln His Val Arg Leu Pro Asn Pro Lys Ile Thr 
                245                 250                 255     


Ser Gln Glu Tyr Thr Lys Glu Glu Leu Leu Leu Arg Met Met Asn Tyr 
            260                 265                 270         


Leu Glu Lys Val Pro Asp Gln Ile Phe Lys Thr Leu Ser Pro Ala Asp 
        275                 280                 285             


Gln Glu Asn Cys Lys Ser Asn Val Asp Val Phe Glu Thr Pro Ile Glu 
    290                 295                 300                 


Gly Asp Leu Ile Glu Lys Ser Leu His Lys Arg Tyr Arg Asp Gln Phe 
305                 310                 315                 320 


Pro Glu Phe Ala Leu Asn Tyr Ile Asp Tyr Tyr Lys Leu Phe Pro Asn 
                325                 330                 335     


Ile Arg Phe Gln Ile Asn Leu Gly Lys Phe Ile Phe Ser Val Lys Asp 
            340                 345                 350         


Lys Glu Ile Leu Gly Glu Thr Arg Lys Arg Arg Gln Ile Gln Met Leu 
        355                 360                 365             


Arg Gly Phe Gly Gln Ile Gln Asp Tyr Gln Asn Lys Lys Asn Ile Pro 
    370                 375                 380                 


Glu Ile Trp Gln Ser Leu Ile Asn Lys Ser His Glu Ile Pro Glu Asp 
385                 390                 395                 400 


Phe Pro Asp Pro Tyr Ile Asn Asp Met Glu Pro His Tyr His Ile Glu 
                405                 410                 415     


Asn Asn Asn Ile Tyr Phe Lys Phe Met Glu Pro Asp Thr Thr His Trp 
            420                 425                 430         


Pro Arg Ile Asp Ala Arg Ile Glu Asn Gln Asn Asn Ile Asn Ala His 
        435                 440                 445             


Pro Arg Pro Arg Leu Leu Gln Ala Asp Gly Ile Leu Ser Val Tyr Glu 
    450                 455                 460                 


Leu Ala Pro Leu Leu Phe Tyr Glu Met Ile Arg Ser Asp Lys Ser Lys 
465                 470                 475                 480 


Ser Ala Glu Thr Ile Leu Ser Ile Gln Lys Ser Asn Ile Glu Arg Leu 
                485                 490                 495     


Leu Asn Asp Ile Lys Ser Gly Glu Leu Thr Lys Val Ala Leu Asp Lys 
            500                 505                 510         


Ile Pro Asn Pro Tyr Ser Pro Ser Asn Lys Lys Phe Asn Thr Ala Lys 
        515                 520                 525             


Gln Val Ile Leu Lys Glu Lys Ile Glu Lys Arg Lys Ile Glu Leu Asn 
    530                 535                 540                 


Glu Lys Leu Lys Lys Tyr Lys Leu Ala Leu Asp Asp Leu Pro Lys Met 
545                 550                 555                 560 


Ile Leu Tyr Tyr Leu Leu Asn Ile Glu His Glu Asp Ile Ser Leu Lys 
                565                 570                 575     


Val Ile Pro Ile Ile Lys Ser Met Gln Val Glu Thr Asn His Leu Leu 
            580                 585                 590         


Asn Lys Leu Gln His Asn Leu Glu Lys Arg Asn Lys Pro Gly Glu Lys 
        595                 600                 605             


Gly Ser Lys Leu Ile Leu Ser Gly Glu Leu Ala Ser Phe Leu Ala Gln 
    610                 615                 620                 


Asp Met Leu Ala Leu Gln Ala Lys Ser Asp Asn Ser Arg Asp Lys Ala 
625                 630                 635                 640 


Asn Ser Gln Glu Tyr Gln His Leu Gln Tyr Lys Leu Ala Tyr Tyr Ser 
                645                 650                 655     


Leu Tyr Ile Asp Glu Phe Lys Ser Ile Phe Lys Lys Leu Asn Leu Ile 
            660                 665                 670         


Asp Ser Asp Lys Phe Ser His Pro Phe Leu Ser Lys Leu Thr Lys Ile 
        675                 680                 685             


Phe Pro Asn Ile Ile Gln Phe Tyr Glu Trp Tyr Leu Asn Glu Arg Lys 
    690                 695                 700                 


Lys Trp Leu Met Asp Ile Glu Thr Lys Pro Glu Glu Ala Leu Lys Phe 
705                 710                 715                 720 


Ile Lys Leu Lys Lys Ser Val Asn Ile Thr Gly Glu Gln Leu Val Asp 
                725                 730                 735     


Gln Phe Leu Val Lys Thr Asn Gly Asn Gln Ala Gly Ile Pro Tyr Asn 
            740                 745                 750         


Phe Pro Arg Gly Ile Phe Asp Asp Ala Ile Lys Ser Glu Leu Glu Lys 
        755                 760                 765             


Asn Asp Lys Met Lys Ala Ile Ile Ser Asn Thr Lys Arg Val Asn Ser 
    770                 775                 780                 


His Phe Leu Ile Asn Arg Tyr Ile Glu His Glu Lys Asn Asn Lys Ser 
785                 790                 795                 800 


Gln Ser Phe Tyr Glu Trp Lys Arg Asn Tyr Glu Ile Tyr Asp Arg Leu 
                805                 810                 815     


Glu Asp Asp Arg Lys Lys Met Phe Asp Pro Leu Pro Lys Lys Tyr Lys 
            820                 825                 830         


Thr Asn Asp Glu Leu Gly His Gly Leu Lys Lys His Arg Glu Tyr Ile 
        835                 840                 845             


Lys Thr Leu Ala Glu Arg Asp Val Ile Lys Arg Gly Asn Ser Asn Leu 
    850                 855                 860                 


Ser Lys Glu Lys Leu Thr Thr Leu Phe Lys Asn Tyr Glu Glu Asn Glu 
865                 870                 875                 880 


Lys Glu Ile Arg Leu Gln Lys Thr Gln Asp Gln Val Leu Tyr Leu Met 
                885                 890                 895     


Ile Val Lys Ser Ile Ser Asp Asn Phe Ser Pro Gly Glu Phe Asn Asn 
            900                 905                 910         


Ile Ala Leu Gln Asp Phe Val Pro Asn Ala Ile Asn Ser Pro Leu Ala 
        915                 920                 925             


Lys Arg Ile Pro Phe Glu Ile Lys Tyr Gly Glu Lys Lys Ile Phe Gln 
    930                 935                 940                 


Glu Glu Ile Gln Ile Lys Lys Ile Gly Glu Phe His Arg Phe Leu Lys 
945                 950                 955                 960 


Asp Arg Arg Leu Ile Asn Leu Met Ala Tyr Ile Lys Lys Glu Arg Ile 
                965                 970                 975     


Ser Arg Ser Glu Leu Glu Tyr Glu Leu Gly Glu Tyr Gln Lys Gln Arg 
            980                 985                 990         


Ile Leu Phe Leu Glu Lys Val Leu  Glu Phe Glu Gln Lys  Leu Tyr Ala 
        995                 1000                 1005             


Tyr Asp  Lys Phe Tyr Phe Asp  Asn Ile Ile Ala Glu  Asn Asn Arg 
    1010                 1015                 1020             


Val Glu  His Trp Gln Tyr Leu  Arg Tyr Phe Glu Glu  Lys Phe Val 
    1025                 1030                 1035             


Leu Thr  Pro Glu Gln Lys Glu  Gln Ser Ser Asn Leu  Arg Asn Lys 
    1040                 1045                 1050             


Phe Ser  His Asn Glu Tyr Pro  Glu Ile Met Tyr Phe  Glu Asp Val 
    1055                 1060                 1065             


Cys Ser  Gly Glu Glu Lys Ile  Gly Val Ala Ser Gln  Leu Ala Gln 
    1070                 1075                 1080             


Ile Gly  Ile Lys Leu Tyr Glu  Asp Met Val Ser Gln  Ile Gln Lys 
    1085                 1090                 1095             


<210>  2246
<211>  1242
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2246

Met Glu Gln Asn Arg Lys Glu Gly Ser Leu Arg Thr Gln Glu Asp Ile 
1               5                   10                  15      


Gln Tyr Phe Gly Ser Tyr Phe Asn Met Ala Arg His Asn Leu Tyr Leu 
            20                  25                  30          


Ile Thr Asn His Leu Thr Ser Val Phe Ser His Leu Asn Phe Ser Gln 
        35                  40                  45              


Leu Asp Asp Asp Glu Asp Ile Trp Ser Asp Lys Pro Glu Val Asn Glu 
    50                  55                  60                  


Lys Asn Ile Leu Leu Asn Ile Phe Asp Thr Lys Asn Glu Arg Leu Gln 
65                  70                  75                  80  


Asp Glu Arg Ile Arg Val Phe Arg Tyr Leu Met Arg Arg His His Leu 
                85                  90                  95      


Pro Cys Leu Arg Ile Phe Thr Asn Asp Phe Lys Val Leu Glu Thr Thr 
            100                 105                 110         


Gly Asn Thr Ile Lys Lys Asp Glu Leu Glu Val Asp Phe Asp Ala Val 
        115                 120                 125             


His Lys Phe Leu Asn Ile Ala Phe Lys Glu Ile Asn Leu Phe Arg Asn 
    130                 135                 140                 


Ser Tyr Thr His Tyr Leu Ser Ile Asn Glu Glu Gly Lys Arg Leu Lys 
145                 150                 155                 160 


Lys Lys Lys Lys Ile Ser Ser Lys Leu Val Pro Val Leu Asn Ser Leu 
                165                 170                 175     


Phe Ser Tyr Ala Pro Glu Tyr Ser Phe Leu Arg His Asn Ile Asp Lys 
            180                 185                 190         


Ala Asn Lys Asp Val Lys Ile Tyr Lys Glu Glu Val Lys Glu Tyr Tyr 
        195                 200                 205             


Asp Asn Ile Lys Ser Lys Tyr Lys Leu Phe Glu Asn Asp Ser Asn Glu 
    210                 215                 220                 


Leu Thr Asp Gln Gly Met Tyr Phe Phe Ile Thr Leu Phe Leu Glu Arg 
225                 230                 235                 240 


Ala His Gly Ile Lys Phe Leu Lys Arg Phe Arg Gly Phe Lys Asn Glu 
                245                 250                 255     


Thr Thr Pro Pro Phe Lys Ala Thr Ile Gln Ala Phe Thr Thr Tyr Thr 
            260                 265                 270         


Leu Lys Ile Pro Asp Val Arg Leu Asp Asn Asp Ile Pro Glu Gln Thr 
        275                 280                 285             


Met Ile Met Glu Val Leu Asn Glu Leu Asn Lys Cys Pro Glu Glu Leu 
    290                 295                 300                 


Phe Lys Phe Leu Lys Lys Glu Asp Lys Asp Arg Phe Gln Pro Val Ile 
305                 310                 315                 320 


Ser Asp Glu Ser Leu Thr Asn Ile Ile Asn Ser Ser Asn Tyr Glu Glu 
                325                 330                 335     


Ile Ser Asp Glu Asp Ile Asp Arg Leu Ile Lys Glu Asn Ser Val Leu 
            340                 345                 350         


Lys Arg Arg Glu Asp Arg Phe Pro Tyr Phe Ala Leu Gln Tyr Leu Glu 
        355                 360                 365             


Ile Met Ser Lys Leu Lys Asn Ile Arg Phe Gln Ile Tyr Leu Gly Lys 
    370                 375                 380                 


Leu Val Leu Lys Thr Tyr Asp Lys Glu Asn Pro Asn Ile Glu Arg Arg 
385                 390                 395                 400 


Val Ile Thr Asp Ile His Ala Phe Gly Lys Leu Ser Asp Phe Val Gly 
                405                 410                 415     


Lys Glu Ala Glu Val Leu Asp Thr Phe Asn Ser Gln Leu Lys Asp Tyr 
            420                 425                 430         


Gly Tyr Ser Val Ala Trp Asp Gln Tyr Lys Pro Ser Tyr Ala Ile Glu 
        435                 440                 445             


Met Asn Arg Ile Gly Phe Tyr Leu Phe Asn Asp Gln Gly Asp Lys Val 
    450                 455                 460                 


Glu Asn Lys Ile Leu Pro Ser Leu Cys Lys Asn Lys Asn Leu Glu Arg 
465                 470                 475                 480 


Lys Val Glu Ile Lys Val Asn Lys Ile Gln Pro Thr Gly Phe Ile Ser 
                485                 490                 495     


Thr His Met Leu Pro Lys Phe Leu Ile Ser Tyr Leu Met Gly Asp Val 
            500                 505                 510         


Asn Glu Lys Asn Gly Glu Lys Thr Ile Thr His Phe Leu Glu Lys Val 
        515                 520                 525             


Asn Val Ser Ile Leu Asp Gln Asn Ile Ile Asn Gln Ile Lys Ser Glu 
    530                 535                 540                 


Ile Gln Asn Leu Asp Pro Ile Glu Phe Thr Lys Arg Cys Pro Lys Leu 
545                 550                 555                 560 


Ser Ala Ile Lys Asn Val Lys Lys Leu Arg Val Ala Gly Ala Ile Asp 
                565                 570                 575     


Lys Lys Ile Val Glu Tyr Gln Tyr Ile Asn Asp Thr Asp Ile Ala Lys 
            580                 585                 590         


Leu Val Gln Lys Thr Gly Leu Ala Tyr Asp Thr Met Val Thr Tyr Ser 
        595                 600                 605             


Lys Asp Lys Phe Lys Glu Lys Thr Asn His Leu Asn Leu Ser Lys Lys 
    610                 615                 620                 


Glu Leu Glu Thr Phe Ala His Ile Lys Tyr Lys Tyr Tyr Leu Ser Glu 
625                 630                 635                 640 


Arg Arg Lys Ala Leu Asp Ser Val Leu Lys Ala Tyr Phe Pro Glu Ile 
                645                 650                 655     


Gly Ser Gln Asp Ile Pro Lys Glu Leu Tyr Asn Tyr Leu Leu Asn Ile 
            660                 665                 670         


Asn Glu Gln Asp Asn Lys Lys Leu Glu His Arg Arg Ile Lys Asp Glu 
        675                 680                 685             


Val Thr Lys Thr Lys Lys Leu Ile Lys Asp Val Asn Arg Ser Leu Lys 
    690                 695                 700                 


Phe Glu Asp Lys Ile Leu Leu Gly Asp Leu Ala Thr Lys Ile Ala Arg 
705                 710                 715                 720 


Asp Ile Ile Asn Met Ile Ile Asp Lys Asp Leu Lys Val Ser Met Thr 
                725                 730                 735     


Asn Pro Phe Ala Asn Arg Leu Gln Asn Leu Ile Ala Tyr Phe Ser Thr 
            740                 745                 750         


Asn Lys Glu Ala Ile Val Ala Leu Cys Glu Ser Tyr Lys Val Phe Glu 
        755                 760                 765             


His Asn Lys Gly His Phe Phe Leu Thr Arg Glu Leu Ile Leu Asn Ser 
    770                 775                 780                 


Thr Gly Val Ile Asp Phe Tyr Ile Arg Tyr Phe Glu Ala Lys Ile Glu 
785                 790                 795                 800 


Lys Ile Lys Glu Val Leu Leu Val Arg Gly Lys Glu Gly Gly Tyr Glu 
                805                 810                 815     


Ile Asn Thr Glu Leu Ile Pro Tyr Ser Tyr Thr Gln Tyr Leu Pro Lys 
            820                 825                 830         


Glu Val Lys Glu Glu Asn Lys Asn Thr Cys Lys Asn Leu Phe Glu Gln 
        835                 840                 845             


Trp Leu Tyr Tyr Lys Gln Lys Ser Pro Val Asn Leu Pro Val Thr Leu 
    850                 855                 860                 


Leu Asp Glu Asp Leu Thr Ser Ala Leu Lys Ser Lys Leu Lys Leu Lys 
865                 870                 875                 880 


Pro Asp Leu Lys Asp Gly Phe Ser Lys Leu Ile Gln Leu Tyr Leu Lys 
                885                 890                 895     


Asp Asp Ala Gln Glu Phe Tyr Ser Phe Asp Arg Val Tyr Arg Asn Asn 
            900                 905                 910         


Asp Asn Glu His Val Ile Lys Tyr Ser Asn Glu Gly Ser Ser Lys Glu 
        915                 920                 925             


Met Gln Ile Lys Tyr Gly Lys Val Ala Val Glu Ser Glu Lys Ile Ile 
    930                 935                 940                 


Arg His Val Leu Leu Lys Asp Arg Ile Leu Arg Val Ile Cys Glu Asp 
945                 950                 955                 960 


Leu Leu Lys Ser Asp Lys Asn Thr Ser Ser Thr Lys Ser Phe Leu Leu 
                965                 970                 975     


Lys Asp Ile Ser Pro Trp Ser Glu Thr Asn Ile Leu Asn Lys Pro Asn 
            980                 985                 990         


Glu Phe Ser Tyr Asn Leu Arg Lys  Asn Ile Asp Gly Ser  Gly Thr Glu 
        995                 1000                 1005             


Tyr Cys  Thr Ile Val Ala Lys  Asp Ser Thr Glu Gln  Ile Arg Gln 
    1010                 1015                 1020             


Ile Asn  Glu Trp Asn Asp Leu  Ser Lys Glu Ile Lys  Ser Lys Phe 
    1025                 1030                 1035             


Leu Lys  Leu Asn Ala Glu Gln  Lys Ile Asp Phe Leu  Thr Thr Gln 
    1040                 1045                 1050             


Asp Glu  Lys Thr Lys Leu Val  Leu Leu Gly Gln Gln  Asn Tyr Gln 
    1055                 1060                 1065             


Trp Lys  Phe Ser Asp Phe Gly  Arg Phe Arg Arg Phe  Met Lys Asp 
    1070                 1075                 1080             


Lys Arg  Ile Asn Glu Met Val  Lys Tyr Phe Glu Pro  Lys Gln Ile 
    1085                 1090                 1095             


Pro Phe  Asp Leu Leu Glu Phe  Gln Ile Leu Gln Tyr  Asn Ile Tyr 
    1100                 1105                 1110             


Arg Glu  Lys Met Phe Asp Lys  Ile Phe Glu Leu Glu  Arg Val Met 
    1115                 1120                 1125             


Ser Glu  Arg Tyr Phe Glu Asp  Ile Lys Ser Lys His  Leu Glu Asn 
    1130                 1135                 1140             


Phe Lys  Tyr Asn Glu Val Gly  Phe Gln Thr Tyr Leu  Asn Val Leu 
    1145                 1150                 1155             


Ser Glu  Lys Ile Ala Ser Gly  Tyr Asp Ile Ala Ile  Leu Lys Trp 
    1160                 1165                 1170             


Gly Arg  Asn Lys Phe Ser His  Thr Glu Ile Val Tyr  Tyr Asn Phe 
    1175                 1180                 1185             


Ile Ser  Lys Ile Ala Val Gln  Asp Ile Glu Glu Phe  Glu Leu Lys 
    1190                 1195                 1200             


Lys His  Leu Glu Gly Tyr Lys  Glu Asn Val Ser Phe  Asn Ile Ala 
    1205                 1210                 1215             


Arg Asn  Ile Tyr Arg Val Phe  Ser Arg Glu Val Asp  Lys Thr Ile 
    1220                 1225                 1230             


Asn Leu  Ile Asn Asn Ser Phe  Lys Ile 
    1235                 1240         


<210>  2247
<211>  1091
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2247

Met Lys Glu Glu Glu Lys Gly Lys Thr Pro Val Val Ser Thr Tyr Asn 
1               5                   10                  15      


Lys Asp Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His 
            20                  25                  30          


Asn Val Tyr Ile Thr Val Asn His Ile Asn Lys Ile Leu Gly Glu Ala 
        35                  40                  45              


Glu Ile Asn Ile Asp Gly Tyr Asp Ile Ser Leu Lys Asn Ile Trp Ser 
    50                  55                  60                  


Gly Ile Arg Asp Ile Asn Lys Lys Ala Arg Leu Glu Glu Leu Met Ile 
65                  70                  75                  80  


Lys His Phe Pro Phe Leu Glu Ala Met Thr His Gln Gln Arg Leu Thr 
                85                  90                  95      


Gly Asn Thr Lys Gln Lys Glu Glu Lys Gln Ala Lys Ile Gln Ser Phe 
            100                 105                 110         


Glu Ile Leu Lys Asp Asn Leu Phe Leu Leu Leu Lys Met Leu Gln Asp 
        115                 120                 125             


Leu Arg Asn His Tyr Ser His Tyr Lys His Ser Lys Ser Leu Glu Arg 
    130                 135                 140                 


Pro Lys Phe Asp Glu Asp Ile Arg Asn Lys Leu Tyr Asn Ile Phe Asp 
145                 150                 155                 160 


Thr Ser Ile Arg Leu Val Lys Glu Asp Tyr Lys His Asn Pro Asp Ile 
                165                 170                 175     


Lys Pro Lys Glu His Phe Lys His Leu Asp Arg Lys Arg Asn Glu Lys 
            180                 185                 190         


Phe Arg Tyr Ser Phe Ala Asp Asn Glu Gly Asn Ile Thr Ile Ser Gly 
        195                 200                 205             


Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp 
    210                 215                 220                 


Val Gln Lys Lys Leu Glu Gly Phe Arg Cys Ser Asn Glu Ser Tyr Gln 
225                 230                 235                 240 


Lys Met Thr Asn Glu Val Phe Cys Arg Asn Arg Ile Leu Met Pro Lys 
                245                 250                 255     


Leu Arg Leu Glu Ser Thr Gln Thr Gln Asn Trp Ile Leu Leu Asp Met 
            260                 265                 270         


Leu Asn Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Lys 
        275                 280                 285             


Gly Glu Asp Arg Lys Lys Phe Glu Val Pro Phe Asp Ser Thr Asp Glu 
    290                 295                 300                 


Asp Tyr Asp Ala Glu Gln Asp Pro Phe Lys Asn Thr Leu Ile Arg His 
305                 310                 315                 320 


Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe Asp Tyr Asn Glu 
                325                 330                 335     


Ile Phe Glu Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe 
            340                 345                 350         


Ser Ile Tyr Lys Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg His Leu 
        355                 360                 365             


Thr His Lys Leu Tyr Gly Phe Glu Arg Leu Gln Glu Phe Ala Lys Gln 
    370                 375                 380                 


Asn Arg Pro Asp Glu Trp Lys Ala Ile Ile Lys Asp Leu Asp Thr Phe 
385                 390                 395                 400 


Lys Lys Gln Glu Asp Glu Lys Val Asn Glu Lys Pro Tyr Ile Ser Glu 
                405                 410                 415     


Thr Thr Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Ala Phe 
            420                 425                 430         


Lys Asn His Asn Ile Trp Pro Thr Thr Asn Thr Glu Leu Thr Asn Asn 
        435                 440                 445             


Lys Arg Lys Lys Tyr Asn Leu Gly Thr Ser Ile Lys Ala Glu Ala Phe 
    450                 455                 460                 


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Met Leu Leu 
465                 470                 475                 480 


Lys Thr Lys Asn Glu Ser Pro Arg Lys Val Glu Ala Ile Ile Glu Ser 
                485                 490                 495     


Lys Ile Lys Asp Ile Phe Thr Leu Tyr Asp Ala Phe Ala Asn Asp Glu 
            500                 505                 510         


Ile Asp Asn Thr Asp Lys Leu Glu Lys Tyr Cys Glu Asp Thr Asp Ile 
        515                 520                 525             


Lys Ile Gly His Leu Pro Lys Gln Met Ile Ala Ile Leu Tyr Asn Lys 
    530                 535                 540                 


His Lys Asp Met Val Glu Lys Ala Lys Val Lys Gln Glu Lys Met Lys 
545                 550                 555                 560 


Leu Ala Thr Glu Asn Arg Leu Lys Thr Leu Asp Lys Leu Ile Glu Gly 
                565                 570                 575     


Lys Met Lys Tyr Ala Lys Arg Gly Ile Ser Pro Leu Lys Ser Gly Glu 
            580                 585                 590         


Ile Ala Ser Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln 
        595                 600                 605             


Arg Asp Glu Asn Gly Glu Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr 
    610                 615                 620                 


Glu Tyr Gln Leu Leu Gln Arg Thr Leu Ala Leu Phe Gly Ser Glu His 
625                 630                 635                 640 


Lys Arg Leu Thr Pro Tyr Phe Lys Gln Met Asn Leu Ile Gly Asp Asn 
                645                 650                 655     


Asn Ser His Pro Phe Leu Lys Gln Thr Glu Trp Glu Glu Cys Asn Asn 
            660                 665                 670         


Ile Leu Ser Phe Tyr Arg Ser Tyr Leu Glu Ala Arg Lys Asn Phe Leu 
        675                 680                 685             


Lys Asn Leu Glu Pro Lys Asp Trp Lys Lys Asn Gln Tyr Phe Leu Lys 
    690                 695                 700                 


Ile Lys Glu Pro Lys Ser Asn Arg Gln Thr Leu Val Gln Gly Trp Lys 
705                 710                 715                 720 


Asn Gly Phe Asn Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Lys Lys 
                725                 730                 735     


Trp Phe Ile Glu His Arg Lys Lys Met Lys Val Asp Glu Leu Lys Ser 
            740                 745                 750         


Val Gly Leu Val Ala Lys Val Ile Pro Leu Tyr Phe Asn Glu Lys Tyr 
        755                 760                 765             


Lys Asp Ser Val Gln Pro Phe Tyr Asn Tyr Pro Phe Asn Val Gly Asp 
    770                 775                 780                 


Ile Asn Lys Pro Lys Glu Lys Asp Phe Leu Asp Asn Gly Lys Arg Arg 
785                 790                 795                 800 


Lys Leu Trp Asp Lys Lys Gln Leu Glu Phe Lys Gly Lys Thr Glu Glu 
                805                 810                 815     


Glu Lys Arg Lys Asn Pro Ser Tyr Leu Asp Phe Lys Ser Trp Lys Lys 
            820                 825                 830         


Phe Glu Arg Glu Leu Arg Leu Ile Arg Asn Gln Asp Ile Val Thr Trp 
        835                 840                 845             


Leu Met Cys Ile Glu Leu Tyr Asn Asn Gln Lys Val Glu Asn Leu Asn 
    850                 855                 860                 


Thr Gly His Ile Tyr Leu Lys Asp Ile Ile Thr Asn Val Lys Glu Glu 
865                 870                 875                 880 


Arg Asn Asn Asn Ile Leu Asn Gln Ile Lys Ser Met Gln Leu Pro Val 
                885                 890                 895     


Thr Val Tyr Glu Asn Glu Ser Ser Pro Lys Lys Lys Tyr Leu Arg Thr 
            900                 905                 910         


Ile Tyr Ile Glu Glu Asn Gly Thr Lys Leu Leu Lys Gln Gly Asn Phe 
        915                 920                 925             


Lys Ala Leu Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Val 
    930                 935                 940                 


Lys Thr Ser Ser Glu Ala Glu Ser Lys Arg Asn Pro Ile Ser Lys Leu 
945                 950                 955                 960 


Arg Val Glu His Glu Leu Arg Glu Tyr Gln Lys Ala Arg Ile Asp Ile 
                965                 970                 975     


Ile Lys Asp Met Leu Ala Leu Glu Lys Thr Leu Ile Asp Asn Tyr Asp 
            980                 985                 990         


Ser Leu Asp Thr Asp Asn Phe His  Asn Met Leu Thr Gly  Trp Leu Glu 
        995                 1000                 1005             


Leu Lys  Gly Glu Ala Ile Lys  Thr Lys Phe Asn Asn  Asp Val Lys 
    1010                 1015                 1020             


Leu Leu  Thr Ala Val Arg Asn  Ala Phe Ser His Asn  Gln Tyr Pro 
    1025                 1030                 1035             


Met Tyr  Asp Glu Asn Leu Phe  Ile Asn Ile Glu Arg  Phe Ser Leu 
    1040                 1045                 1050             


Ser Ser  Ser Arg Ile Leu Glu  Ser Lys Gly Leu Gly  Ile Ala Val 
    1055                 1060                 1065             


Lys Leu  Lys Glu Glu Val Ser  Asn Ala Ile Glu Lys  Ile Lys Asn 
    1070                 1075                 1080             


Glu Glu  Asp Ala Lys Lys Glu  Thr 
    1085                 1090     


<210>  2248
<211>  1118
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2248

Met Lys Glu Glu Glu Thr Pro Val Val Ser Thr Tyr Asn Lys Asp Asp 
1               5                   10                  15      


Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val Tyr 
            20                  25                  30          


Ile Thr Ile Asn His Ile Asn Lys Leu Leu Glu Ile Arg Glu Ile Asp 
        35                  40                  45              


Asn Asp Glu Lys Ile Leu Asp Ile Lys Ala Leu Trp Gln Lys Val Asn 
    50                  55                  60                  


Lys Asp Leu Asn Gln Lys Ala Arg Leu Arg Glu Leu Met Thr Lys His 
65                  70                  75                  80  


Phe Pro Phe Leu Glu Thr Ala Ile Tyr Thr Lys Asn Lys Glu Asp Lys 
                85                  90                  95      


Lys Glu Val Lys Glu Glu Lys Gln Ala Lys Ala Gln Ser Phe Asp Ser 
            100                 105                 110         


Leu Asn His Cys Leu Phe Leu Phe Leu Glu Lys Leu Gln Glu Ala Arg 
        115                 120                 125             


Asn Tyr Tyr Ser His Tyr Lys Tyr Ser Glu Ser Thr Lys Glu Pro Val 
    130                 135                 140                 


Leu Glu Lys Glu Leu Leu Lys Lys Met Tyr Asn Ile Phe Asp Asn Asn 
145                 150                 155                 160 


Ile Gln Leu Val Ile Lys Asp Tyr Gln His Asn Lys Asp Ile Asn Pro 
                165                 170                 175     


Asp Glu Asp Phe Lys His Leu Asp Arg Thr Glu Lys Glu Phe Asn Tyr 
            180                 185                 190         


Tyr Phe Thr Gln Asp Lys Lys Gly Lys Ile Thr Glu Ser Gly Leu Leu 
        195                 200                 205             


Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Met Gln 
    210                 215                 220                 


Gln Lys Phe Thr Gly Phe Lys Asp Asn Arg Glu Asn Asn Lys Gln Met 
225                 230                 235                 240 


Thr His Glu Val Phe Cys Arg Ser Arg Met Leu Leu Pro Lys Leu Arg 
                245                 250                 255     


Leu Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu Asn 
            260                 265                 270         


Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Lys Gly Glu 
        275                 280                 285             


Asp Arg Lys Lys Phe Glu Val Pro Phe Asp Ser Thr Asp Glu Asp Tyr 
    290                 295                 300                 


Asp Ala Glu Gln Asp Pro Phe Lys Asn Thr Leu Ile Arg His Gln Asp 
305                 310                 315                 320 


Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe Asp Tyr Asn Glu Ile Phe 
                325                 330                 335     


Lys Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile 
            340                 345                 350         


Tyr Lys Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg His Leu Thr His 
        355                 360                 365             


Lys Leu Tyr Gly Phe Glu Arg Leu Gln Glu Phe Thr Lys Gln His Arg 
    370                 375                 380                 


Pro Asp Asp Trp Lys Ala Ile Val Lys Asp Phe Asp Thr Tyr Glu Thr 
385                 390                 395                 400 


Ser Glu Glu Pro Tyr Ile Ser Glu Thr Thr Pro His Tyr His Leu Glu 
                405                 410                 415     


Asn Gln Lys Ile Gly Ile Arg Phe Lys Asn Asp Asn Asp Lys Ile Trp 
            420                 425                 430         


Pro Ser Leu Glu Thr Asn Gly Glu Asn Asn Glu Lys Ser Lys Tyr Lys 
        435                 440                 445             


Leu Asp Lys Gln Tyr Gln Ala Glu Ala Phe Leu Ser Val His Glu Leu 
    450                 455                 460                 


Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Lys Lys Glu Glu Pro Asn 
465                 470                 475                 480 


Asn Asp Lys Lys Asn Ala Ser Arg Val Glu Gly Phe Ile Lys Arg Glu 
                485                 490                 495     


Ile Arg Asp Ile Phe Lys Leu Tyr Asp Ala Phe Ala Asn Asp Glu Ile 
            500                 505                 510         


Asn Asn Ile Asp Asp Leu Lys Lys Tyr Tyr Lys Asp Lys Asn Val Glu 
        515                 520                 525             


Ile Arg His Leu Pro Lys Gln Met Ile Ala Ile Leu Glu Ser Lys Pro 
    530                 535                 540                 


Lys Asp Met Ala Lys Glu Ala Lys Arg Lys Gln Lys Glu Met Val Lys 
545                 550                 555                 560 


Asp Thr Lys Lys Leu Leu Ala Thr Leu Glu Lys Gln Thr Gln Lys Glu 
                565                 570                 575     


Lys Glu Asp Asn Gly Arg Asn Val Lys Leu Leu Lys Ser Gly Glu Ile 
            580                 585                 590         


Ala Arg Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln Lys 
        595                 600                 605             


Asp Asn Glu Gly Asn Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu 
    610                 615                 620                 


Tyr Gln Met Leu Gln Arg Ser Leu Ala Leu Tyr Asn Lys Glu Glu Lys 
625                 630                 635                 640 


Pro Thr Arg Tyr Phe Arg Gln Val Asn Leu Ile Glu Ser Ser Asn Pro 
                645                 650                 655     


His Pro Phe Leu Lys Trp Thr Lys Trp Glu Glu Cys Asn Asn Ile Leu 
            660                 665                 670         


Thr Phe Tyr His Arg Tyr Leu Thr Lys Lys Ile Glu Phe Leu Asn Lys 
        675                 680                 685             


Leu Lys Pro Glu Asp Trp Lys Lys Asn Gln Tyr Phe Leu Lys Val Lys 
    690                 695                 700                 


Glu Pro Lys Thr Asn Arg Glu Thr Leu Val Gln Gly Trp Lys Asn Gly 
705                 710                 715                 720 


Phe Asn Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg Glu Trp Phe 
                725                 730                 735     


Glu Arg His Gln Asn Asp Ser Glu Glu Tyr Lys Lys Val Glu Ala Leu 
            740                 745                 750         


Gly Arg Val Gly Leu Val Thr Lys Val Ile Pro Leu Phe Phe Lys Lys 
        755                 760                 765             


Glu Tyr Phe Lys Glu Asp Ala Arg Lys Glu Ile Asn Asp Cys Val Gln 
    770                 775                 780                 


Pro Phe Tyr Asn Phe Pro Tyr Asn Val Gly Asn Ile Tyr Arg Leu Lys 
785                 790                 795                 800 


Asp Glu Asp Phe Leu His Arg Glu Glu Arg Ile Lys Leu Trp Asn Asn 
                805                 810                 815     


Lys Lys Asp Lys Phe Lys Gly Tyr Lys Glu Lys Ile Lys Ser Lys Lys 
            820                 825                 830         


Leu Thr Glu Lys Glu Lys Glu Glu Phe Arg Ser Tyr Leu Glu Phe Gln 
        835                 840                 845             


Ser Trp Asn Asn Phe Glu Arg Glu Leu Arg Leu Val Arg Asn Gln Asp 
    850                 855                 860                 


Ile Val Thr Trp Leu Leu Cys Lys Glu Leu Ile Asp Lys Leu Lys Ile 
865                 870                 875                 880 


Asp Glu Leu Asn Ile Glu Glu Leu Lys Lys Leu Arg Leu Asn Asn Ile 
                885                 890                 895     


Asp Thr Asp Thr Ala Lys Lys Glu Lys Asn Asn Ile Leu Asn Arg Val 
            900                 905                 910         


Met Pro Met Glu Leu Leu Val Met Val Tyr Glu Val Asn Lys Ala Gly 
        915                 920                 925             


Asn Ile Ile Lys Asn Lys Pro Leu His Thr Ile Tyr Ile Lys Glu Ala 
    930                 935                 940                 


Lys Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys Asp 
945                 950                 955                 960 


Arg Arg Leu Asn Gly Leu Phe Ser Phe Val Lys Thr Asn Ser Glu Ala 
                965                 970                 975     


Glu Ser Lys Arg Asn Pro Ile Ser Lys Leu Leu Val Glu Tyr Glu Leu 
            980                 985                 990         


Gly Glu Tyr Gln Glu Ala Arg Ile  Glu Ile Ile Lys Asp  Met Leu Ala 
        995                 1000                 1005             


Leu Glu  Glu Thr Leu Ile Asn  Lys Tyr Lys Asp Leu  Pro Thr Asn 
    1010                 1015                 1020             


Lys Phe  Ser Asp Met Leu Asn  Ser Trp Leu Glu Gly  Lys Asp Glu 
    1025                 1030                 1035             


Ala Asp  Lys Ala Arg Phe Gln  Asn Asp Val Asp Phe  Leu Ile Ala 
    1040                 1045                 1050             


Val Arg  Asn Ala Phe Ser His  Asn Gln Tyr Pro Met  His Asn Lys 
    1055                 1060                 1065             


Ile Glu  Phe Ala Asn Ile Lys  Pro Phe Ser Leu Tyr  Thr Met Asn 
    1070                 1075                 1080             


Asn Ser  Glu Glu Lys Gly Leu  Gly Ile Ala Asn Gln  Leu Lys Asp 
    1085                 1090                 1095             


Lys Thr  Lys Glu Thr Lys Asp  Lys Ile Ile Glu Ile  Glu Lys Pro 
    1100                 1105                 1110             


Ile Glu  Thr Lys Glu 
    1115             


<210>  2249
<211>  1160
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2249

Met Glu Thr Gln Glu Gln Ile Ala Lys Asn Ile Tyr Tyr Ala His Asp 
1               5                   10                  15      


Ile Tyr Glu Asp Lys His Tyr Phe Gly Ala Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Gly Gln Val Phe Ser Glu Phe Cys Thr Arg Leu Asn Glu 
        35                  40                  45              


Pro Lys Asp Glu Asn Val His Asn Ile Ile Ile Lys Tyr Phe Ser Asn 
    50                  55                  60                  


Asn Val Ser Tyr Ser Asp Trp Asp Lys Arg Ile Lys Ile Leu Lys Glu 
65                  70                  75                  80  


Tyr Leu Pro Val Ile Glu His Leu Asn Leu Pro Thr Ser Asp Asn Ile 
                85                  90                  95      


Phe Glu Glu Tyr Gln Ile Asn Glu Lys Glu Asn Lys Lys Arg Asp Tyr 
            100                 105                 110         


Phe Arg Lys Asn Phe Gln Ser Leu Ile Lys Ser Val Asn Asp Leu Arg 
        115                 120                 125             


Asn Phe Tyr Thr His Tyr Tyr His Pro Pro Val Val Ile Asp Glu Ser 
    130                 135                 140                 


Leu Phe Asp Phe Leu Asp Ser Leu Leu Leu Lys Thr Cys Leu Thr Val 
145                 150                 155                 160 


Arg Lys Lys Lys Met Lys Asn Asp Lys Thr Arg Gln Ile Leu Lys Lys 
                165                 170                 175     


Gly Ile Ile Ala Glu Trp Lys Val Leu Glu Glu Leu Lys Val Asn Glu 
            180                 185                 190         


Leu Lys Lys Asn Lys Glu Lys Asn Lys Trp Ile Asn Ile Asp Asp Lys 
        195                 200                 205             


Glu Gly Ile Arg Asn Ala Ile Leu Asn Asp Ser Phe His His Leu Ile 
    210                 215                 220                 


Phe Lys Asp Lys Asp Ser Phe Cys Leu Lys Asp Tyr His Lys Ala Lys 
225                 230                 235                 240 


Tyr Ser Lys Asn Ile Phe Ala Glu Asn Lys Ile Pro Ile Ser Lys Ser 
                245                 250                 255     


Gly Leu Val Phe Leu Leu Ser Leu Phe Leu Thr Lys Lys Glu Thr Glu 
            260                 265                 270         


Gln Leu Lys Ala Asn Ile Glu Gly Phe Lys Ala Lys Val Ile Gly Lys 
        275                 280                 285             


Glu Asp Glu Val Thr Lys Lys Asn Asn Ser Leu Lys Tyr Met Ala Thr 
    290                 295                 300                 


His Trp Val Phe Ser Tyr Leu Thr Tyr Lys Gly Leu Lys Arg Arg Val 
305                 310                 315                 320 


Ser Thr Ser Phe Asp Lys Val Thr Leu Leu Thr Gln Met Leu Asp Glu 
                325                 330                 335     


Leu Ser Lys Val Pro Asp Glu Val Tyr Gln Thr Phe Ser Ile Ser Asp 
            340                 345                 350         


Lys Asp Glu Phe Leu Glu Asp Ile Asn Glu Phe Val Gln Glu Ser Thr 
        355                 360                 365             


Gly Asp Asp Lys Ser Leu Ile Glu Ser Thr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Asn Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu 
385                 390                 395                 400 


Asp Glu Tyr Ala Asn Phe Pro Thr Leu Lys Phe Gln Ile Phe Ala Gly 
                405                 410                 415     


Leu Phe Gln His Asp His Lys Thr Lys Asn Ile Gly Glu Ser Asn Tyr 
            420                 425                 430         


Ile Ser Asp Arg Gln Ile Lys Glu Lys Ile Asn Val Phe Gly Lys Leu 
        435                 440                 445             


Ser Lys Val Ala Lys Tyr Lys Ser Asp Tyr Phe Thr Glu Asn Glu Asn 
    450                 455                 460                 


Glu Asn Glu Trp His Leu Phe Pro Asn Pro Ser Tyr Asn Phe Val Gly 
465                 470                 475                 480 


Asn Asn Ile His Ile Tyr Phe Asp Met Tyr Arg Lys Gly Ala Glu Val 
                485                 490                 495     


Lys Ser Val Gln Glu Glu Ile Asn Ala Leu Arg Lys Ile Ile Asn Pro 
            500                 505                 510         


Lys Lys Asp Arg Val Asn Arg Lys Gly Lys Lys Glu Ile Ile Asp Met 
        515                 520                 525             


Ile Tyr Asn Lys Ser Ser Lys Ile Glu Tyr Asn Glu Pro Thr Ala Leu 
    530                 535                 540                 


Phe Ser Leu Asn Glu Leu Pro Ala Ile Leu Tyr Glu Phe Leu Ile Asn 
545                 550                 555                 560 


Lys Lys Thr Gly Glu Asp Leu Glu Asn Ile Leu Val Gln Lys Ile Val 
                565                 570                 575     


Glu Arg Tyr Lys Thr Ile Lys Asn Tyr Asn Thr Thr Gln Gln Leu Ser 
            580                 585                 590         


Asn Ser Phe Ile Thr Lys Lys Leu Arg Lys Ser Ser Leu Lys Gln Asp 
        595                 600                 605             


Gln Ile Asn Ile Glu Lys Leu Leu Arg Ser Ile Asn Lys Glu Ile Glu 
    610                 615                 620                 


Ile Asn Gly Glu Lys Leu Asn Leu Ile Lys Thr Asn Lys Glu Glu Thr 
625                 630                 635                 640 


Thr Lys Thr Asn Lys Gln Asp Lys Pro Glu Arg Lys Tyr Ile Phe Tyr 
                645                 650                 655     


Thr Asn Glu Leu Gly Gln Glu Ala Thr Trp Leu Ala Asn Asp Leu Val 
            660                 665                 670         


Arg Phe Met Pro Lys Phe Ala Lys Thr Asn Trp Lys Gly Tyr Gln His 
        675                 680                 685             


Ser Glu Leu Gln Arg Leu Leu Ala Phe Tyr Asp Arg His Lys Asn Glu 
    690                 695                 700                 


Ala Lys Thr Leu Leu Thr Thr Asn Trp Asp Leu Asn Ser Phe Pro Ile 
705                 710                 715                 720 


Trp Gly Ser Asp Ile Asn Glu Ala Phe Asp Lys Asp Lys Phe Asp Glu 
                725                 730                 735     


Phe Tyr Glu Glu Tyr Leu Lys Lys Arg Lys Lys Thr Leu Glu Gly Phe 
            740                 745                 750         


Ala Asn Thr Ile Glu Leu Asn Lys Asn Asp Pro Lys Leu Leu Lys Lys 
        755                 760                 765             


Val Leu Lys Glu Val Phe Ile Ala Phe Asp Lys Arg Leu Phe Val Ile 
    770                 775                 780                 


Ser Ser Ile Asp Lys Gln Lys Asn Glu Leu Leu Ala Lys Pro Ile Val 
785                 790                 795                 800 


Phe Pro Arg Gly Ile Phe Asp Asn Lys Pro Thr Phe Ile Leu Gly Gln 
                805                 810                 815     


Lys Val Glu Gln Ala Pro Ser Leu Tyr Ala Asp Trp Tyr Ser Tyr Cys 
            820                 825                 830         


Tyr Asp Lys Ser Leu Arg Phe Gln Lys Phe Tyr Asp Phe Asn Arg Glu 
        835                 840                 845             


Cys Thr Asp Ser Phe Glu Lys Tyr Glu Val Glu Asn Lys Glu Ser Lys 
    850                 855                 860                 


Leu Asn Lys Lys Asn Leu Ser Arg Gln Gln Lys Ile Asp Leu Phe Lys 
865                 870                 875                 880 


Lys Lys Gln Asp Leu Leu Ile Lys Lys Val Gln His Lys Asp Ile Phe 
                885                 890                 895     


Ile Lys His Met Ile Asp Tyr Leu Phe Phe Lys Val Phe Lys Lys Glu 
            900                 905                 910         


Ile Asp Ile Ser Leu Asn Glu Ile Tyr Gln Thr Lys Glu Glu Arg Leu 
        915                 920                 925             


Asn Asn Gln Ile Val Ala Ile Glu Gln Arg Asp Arg Glu Lys Gly Asp 
    930                 935                 940                 


Lys Ser Glu Asn Lys Leu Ile Asp Asn Phe Ile Trp Asn Lys Thr Ile 
945                 950                 955                 960 


Ser Met Ser Leu Leu Asn Gly Gln Ile Ile Glu Pro Asp Val Lys Leu 
                965                 970                 975     


Lys Asp Ile Gly Lys Phe Lys Lys Leu Glu Thr Asp Lys Lys Val His 
            980                 985                 990         


His Leu Leu Ser Tyr Asp Lys Thr  Lys Ile Trp Asn Lys  Leu Met Leu 
        995                 1000                 1005             


Glu Asp  Glu Leu Glu Asn Lys  Leu Asp Ser Tyr Glu  Arg Ile Arg 
    1010                 1015                 1020             


Arg Glu  Lys Leu Leu Lys Leu  Val Gln Leu Phe Glu  Lys Gly Ile 
    1025                 1030                 1035             


Ile Glu  Asn His Ser Glu Asn  Asn Asp Glu His Pro  Lys Glu Phe 
    1040                 1045                 1050             


Glu Lys  Asp Gly Lys Pro Asn  Phe Arg Lys Tyr Ile  Ala Lys Gly 
    1055                 1060                 1065             


Val Leu  Lys Lys Asn Thr Lys  Ile Ala Glu Ser Glu  Ile Asn Trp 
    1070                 1075                 1080             


Leu Ser  Asp Ile Lys Asp Met  Glu Thr Val Glu Ile  Ser Glu Val 
    1085                 1090                 1095             


Asn Ser  Lys Ser Val Ile Leu  Gln Lys Ala Tyr Thr  Leu Ile Leu 
    1100                 1105                 1110             


Leu Arg  Asn Lys Phe Gly His  Asn Gln Leu Pro Asp  Lys Asn Ala 
    1115                 1120                 1125             


Phe Asp  Met Met Gln Thr Leu  Tyr Lys Thr Ala Glu  Asn Glu Thr 
    1130                 1135                 1140             


Tyr Ser  Lys Tyr Phe Leu Arg  Val Thr Glu Gln Ile  Ile Asn Glu 
    1145                 1150                 1155             


Phe Ser  
    1160 


<210>  2250
<211>  1126
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2250

Met Glu Thr Asn Gln Lys Pro Asn Tyr Lys Lys Phe Thr Asn Glu Gln 
1               5                   10                  15      


Asp Lys Pro Phe Phe Ser Gly Tyr Leu Asn Thr Ala Lys Gln Asn Val 
            20                  25                  30          


Phe Ile Ile Phe Arg Asp Ile Ser Glu Arg Leu Gly Leu Gly Phe Asp 
        35                  40                  45              


Leu Ser Asn Asp Asp Asn Ile Met Asn Ala Asp Leu Trp Glu Tyr Leu 
    50                  55                  60                  


Lys Asn Asn Lys Arg Pro Glu Ile Thr Gln His Ile Ile Glu Lys Leu 
65                  70                  75                  80  


Met Tyr His Phe Pro Phe Ala Ser His Leu Thr Thr Asn Tyr Ala Tyr 
                85                  90                  95      


Tyr Lys Arg Lys Glu Asn Gln Ala Glu Pro Leu Asp Tyr Tyr Glu Ile 
            100                 105                 110         


Phe Glu Leu Leu Ile Lys Gln Leu Tyr Glu Tyr Arg Asn Phe Tyr Thr 
        115                 120                 125             


His Val Val His Asp Pro Val Ile Met Asn Lys Val Ile Ile Asn Gly 
    130                 135                 140                 


Met Arg Ile Leu Phe Asp Ala Ala Arg Ile Glu Val Lys Asp Arg Phe 
145                 150                 155                 160 


Asn Leu Lys Thr Glu Asp Val Asn His Leu Val Arg Leu Gly Pro Lys 
                165                 170                 175     


Gly Lys Glu Asn Lys Asn Phe Tyr Tyr Asn Phe Ser Asp Asp Glu Arg 
            180                 185                 190         


Asn Val Ser Glu Lys Gly Leu Ala Phe Phe Ile Cys Leu Gly Leu Gln 
        195                 200                 205             


Arg Lys Asp Ala Gln Ile Phe Leu Lys Ser Leu Val Gly Phe Lys Leu 
    210                 215                 220                 


Ser Glu Ser Pro Ser Gln Lys Ala Thr Leu Glu Val Tyr Thr Asn Tyr 
225                 230                 235                 240 


Ser Pro Arg Ile Pro Gln Pro Arg Leu Thr Ser Asp Asn Ser Ile Glu 
                245                 250                 255     


Gly Leu Leu Leu Asp Met Val Asn Glu Leu Lys Arg Cys Pro Lys Glu 
            260                 265                 270         


Leu Tyr His Leu Leu Ser Ile Glu Asp Arg Glu Lys Phe Lys Ala Val 
        275                 280                 285             


Lys Glu Asp Asn Thr Tyr Asp Asp Asn Asp Glu Tyr Glu Ala Met Pro 
    290                 295                 300                 


Val Leu Lys Arg Ser Arg Asn Arg Phe Phe Tyr Phe Ala Leu Arg Tyr 
305                 310                 315                 320 


Leu Asp Asn Asn Leu Gln Asn Ile Lys Phe His Ile Asp Leu Gly Asn 
                325                 330                 335     


Tyr Cys Phe His Val Tyr Glu Gln Glu Ile Glu Glu Ile Val Arg Lys 
            340                 345                 350         


Arg Arg Trp Ile Lys Arg Met Thr Ser Phe Gly Asn Leu Glu Asp Phe 
        355                 360                 365             


Ala Asp Lys Met Arg Pro Ala Tyr Trp Val Glu Lys Thr Leu Lys Leu 
    370                 375                 380                 


Glu Asp Lys Lys Val Asp Asn Pro Asn Ile Tyr Ile Thr Asp Thr Thr 
385                 390                 395                 400 


Pro His Tyr His Ile Asn Gly Gln Asn Ile Gly Ile Lys Phe Ile Asn 
                405                 410                 415     


Asn Tyr Val Ala Leu Arg Lys Asn Asn Lys Ile Trp Pro Glu Leu Pro 
            420                 425                 430         


Asp Phe Gly Asp Asn Asn Lys Thr Asn Lys Pro Arg Asn Glu Thr Pro 
        435                 440                 445             


Asp Cys Trp Leu Ser Leu Tyr Glu Leu Pro Ser Ile Val Phe Tyr His 
    450                 455                 460                 


Leu Leu Lys Gln Gln Asn Ile Gly Leu Pro Ser Val Glu Arg Ile Ile 
465                 470                 475                 480 


Asn Asp His Arg Asn Gln Ile Arg Gly Phe Phe Asn Asp Leu Glu Asn 
                485                 490                 495     


Asn Arg Ile Val Pro Ser Phe Thr Asp Thr Thr Leu Lys Ala Glu Leu 
            500                 505                 510         


Lys Asn Arg Gly Leu Lys Lys Ser Gln Ile Pro Ser Ala Ile Val Lys 
        515                 520                 525             


Tyr Leu Thr Ser Lys Pro Val Met Ser Phe Glu Ala Lys Ala Ser Lys 
    530                 535                 540                 


Arg Leu Ser Glu Leu Val Thr Glu Thr Ser Glu Lys Leu Asp Lys Ile 
545                 550                 555                 560 


Lys Arg Gln Glu Gln His Tyr Leu Lys Lys Pro Gly Ser Lys Asp Tyr 
                565                 570                 575     


Ile Asp Met Lys Cys Gly His Leu Ala Asp Phe Leu Ala Arg Asp Met 
            580                 585                 590         


Ile Ser Leu Gln Lys Pro Tyr Asn Asn Met Asp Gly Lys Ala Asn Ser 
        595                 600                 605             


Thr Glu Phe Gln Ile Leu Gln Ser Lys Leu Ala Tyr Phe Gly Lys Asn 
    610                 615                 620                 


Lys Asp Ser Leu Ser Lys Thr Phe His Leu Phe Asn Leu Met Gly Ser 
625                 630                 635                 640 


Gln Asn Ile His Pro Phe Leu Tyr Lys Ile Asp Ile Asn Gln Cys Ile 
                645                 650                 655     


Gly Ile Leu Asp Phe Tyr Lys Lys Tyr Leu Asp His Arg Tyr Ile Tyr 
            660                 665                 670         


Phe Lys Gln Cys Leu Asn Glu Lys Arg Tyr Ser Glu Tyr His Phe Leu 
        675                 680                 685             


Lys Leu Gly Gly Lys Ser Lys Glu Gln Gly Arg Asp Tyr Phe Val Lys 
    690                 695                 700                 


Leu Ala Asn Thr Leu Gln Lys Glu Thr Val Met Asn Leu Pro Arg Gly 
705                 710                 715                 720 


Leu Phe Leu Glu Ser Ile Ile Arg Ile Leu Lys Ala Asn Asp Asn Ser 
                725                 730                 735     


Arg Pro Phe Ala Ile Glu Ile Glu Lys Met Glu Arg Val Asn Ala Ala 
            740                 745                 750         


Tyr Val Ile Asp Gln Tyr Leu Gly Arg Ile Leu Asn Asp Lys Pro Gln 
        755                 760                 765             


Val Phe Tyr Ser Tyr Asn Lys Ser Tyr Glu Phe Leu Asn Lys Leu Phe 
    770                 775                 780                 


Asp Ser Arg Lys Ile Ser Glu Lys Arg Asn Ala Leu Pro Glu Val Tyr 
785                 790                 795                 800 


Phe Asp Thr Gly Glu Leu Ala Lys Lys Thr Thr Ile Ser Val Lys Gly 
                805                 810                 815     


Gln Lys Asp Asn Glu Ile Thr Arg Ser Leu Thr Lys Thr Val Glu Gln 
            820                 825                 830         


His Ile Lys Arg Asn Arg Ile Phe Asp Glu Lys Glu Lys Thr Lys Val 
        835                 840                 845             


Tyr Asp Gln Tyr Met Ala Arg Tyr Asn Asp Phe Thr Glu Asn Glu Lys 
    850                 855                 860                 


Gln Ile Arg Leu Ala Lys Thr Cys Asp Glu Val Met Phe Met Met Ile 
865                 870                 875                 880 


Asp Asp Ile Phe Arg Lys Tyr Phe Val Leu Asp Asn Gly Thr Leu Lys 
                885                 890                 895     


Lys Lys Thr Ile Glu Ala Ile Pro Phe Ile Gln Leu Gly Asp Asp Tyr 
            900                 905                 910         


Lys Leu Gly Ser Ile Lys Pro Asp Ser Glu Lys Gly Phe Leu Ser Leu 
        915                 920                 925             


Gln Thr Thr Val Lys Leu Gln Met Pro Phe Thr Tyr Glu Thr Asn Thr 
    930                 935                 940                 


Asp Lys Val Leu Lys Val Lys Gly Ala Glu Ser Lys Leu Ser Ala Arg 
945                 950                 955                 960 


Tyr Ile Lys Thr Ile Val Arg Glu Thr Ile Lys Ile Lys Asn Tyr Gly 
                965                 970                 975     


Asp Phe Arg Ala Phe Leu Lys Asp Arg Arg Ile Ser Ser Leu Leu Pro 
            980                 985                 990         


Tyr Leu Ser Asp Arg Glu Ile His  Tyr Glu Ala Leu Gln  Lys Glu Leu 
        995                 1000                 1005             


Glu Leu  Phe Gln Lys Ala Arg  Met Glu Val Phe Asp  Arg Ile Phe 
    1010                 1015                 1020             


Arg Phe  Glu Lys Asp Ile Thr  Gly Ala Phe His Ile  Pro Lys Asn 
    1025                 1030                 1035             


Lys Asn  Gly Tyr Ile Tyr His  Thr Glu Ile Leu Lys  Gln Lys Ile 
    1040                 1045                 1050             


Asn Glu  Gly Asp Glu Arg Phe  Gly Phe Ile Lys Glu  Leu Arg Asn 
    1055                 1060                 1065             


Ala Phe  Asn His Ser Asn Tyr  Pro Ala Tyr Val Leu  Phe Lys Asp 
    1070                 1075                 1080             


Phe Ile  Asp Gly Ser Gln Phe  Asn Glu Leu Arg Asn  Tyr Lys Ser 
    1085                 1090                 1095             


Gly Asp  Thr Glu Val Glu Asn  Lys Ser Val Ile Leu  Gln Phe Lys 
    1100                 1105                 1110             


Asn Leu  Leu Ile Gln Tyr Tyr  Asp Glu Leu Thr Asp  Leu 
    1115                 1120                 1125     


<210>  2251
<211>  1133
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2251

Met Lys Glu Glu Glu Lys Gly Lys Thr Pro Val Val Ser Thr Tyr Asn 
1               5                   10                  15      


Lys Asp Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His 
            20                  25                  30          


Asn Val Tyr Ile Thr Val Asn His Ile Asn Lys Ile Leu Gly Glu Gly 
        35                  40                  45              


Glu Ile Asn Arg Asp Gly Tyr Glu Asn Thr Leu Glu Lys Ser Trp Asn 
    50                  55                  60                  


Glu Ile Lys Asp Ile Asn Lys Lys Asp Arg Leu Ser Lys Leu Ile Ile 
65                  70                  75                  80  


Lys His Phe Pro Phe Leu Glu Val Thr Thr Tyr Gln Arg Asn Ser Ala 
                85                  90                  95      


Asp Thr Thr Lys Gln Lys Glu Glu Lys Gln Ala Glu Ala Gln Ser Leu 
            100                 105                 110         


Glu Ser Leu Lys Lys Ser Phe Phe Val Phe Ile Tyr Lys Leu Arg Asp 
        115                 120                 125             


Leu Arg Asn His Tyr Ser His Tyr Lys His Ser Lys Ser Leu Glu Arg 
    130                 135                 140                 


Pro Lys Phe Glu Glu Asp Leu Gln Glu Lys Met Tyr Asn Ile Phe Asp 
145                 150                 155                 160 


Ala Ser Ile Gln Leu Val Lys Glu Asp Tyr Lys His Asn Thr Asp Ile 
                165                 170                 175     


Lys Thr Glu Glu Asp Phe Lys His Leu Asp Arg Lys Gly Gln Phe Lys 
            180                 185                 190         


Tyr Ser Phe Ala Asp Asn Glu Gly Asn Ile Thr Glu Ser Gly Leu Leu 
        195                 200                 205             


Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Val Gln 
    210                 215                 220                 


Lys Lys Leu Glu Gly Phe Lys Cys Ser Asn Glu Ser Tyr Gln Lys Met 
225                 230                 235                 240 


Thr Asn Glu Val Phe Cys Arg Ser Arg Met Leu Leu Pro Lys Leu Arg 
                245                 250                 255     


Leu Gln Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu Asn 
            260                 265                 270         


Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Arg Glu Glu 
        275                 280                 285             


Asp Arg Lys Lys Phe Arg Val Pro Ile Glu Ile Ala Asp Glu Asp Tyr 
    290                 295                 300                 


Asp Ala Glu Gln Glu Pro Phe Lys Asn Ala Leu Val Arg His Gln Asp 
305                 310                 315                 320 


Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Tyr Asn Glu Ile Phe 
                325                 330                 335     


Thr Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile 
            340                 345                 350         


Tyr Lys Lys Gln Ile Gly Asp Tyr Lys Glu Ser His His Leu Thr His 
        355                 360                 365             


Lys Leu Tyr Gly Phe Glu Arg Ile Gln Glu Phe Thr Lys Gln Asn Arg 
    370                 375                 380                 


Pro Asp Glu Trp Arg Lys Phe Val Lys Thr Phe Asn Ser Phe Glu Thr 
385                 390                 395                 400 


Ser Lys Glu Pro Tyr Ile Pro Glu Thr Thr Pro His Tyr His Leu Glu 
                405                 410                 415     


Asn Gln Lys Ile Gly Ile Arg Phe Arg Asn Asp Asn Asp Lys Ile Trp 
            420                 425                 430         


Pro Ser Leu Lys Thr Asn Ser Glu Lys Asn Glu Lys Ser Lys Tyr Lys 
        435                 440                 445             


Leu Asp Lys Ser Phe Gln Ala Glu Ala Phe Leu Ser Val His Glu Leu 
    450                 455                 460                 


Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Lys Thr Glu Asn Thr Asp 
465                 470                 475                 480 


Asn Asp Asn Glu Ile Glu Thr Lys Lys Lys Glu Asn Lys Asn Asp Lys 
                485                 490                 495     


Gln Glu Lys His Lys Ile Glu Glu Ile Ile Glu Asn Lys Ile Thr Glu 
            500                 505                 510         


Ile Tyr Ala Leu Tyr Asp Ala Phe Ala Asn Gly Lys Ile Asn Ser Ile 
        515                 520                 525             


Asp Lys Leu Glu Glu Tyr Cys Lys Gly Lys Asp Ile Glu Ile Gly His 
    530                 535                 540                 


Leu Pro Lys Gln Met Ile Ala Ile Leu Lys Ser Glu His Lys Asp Met 
545                 550                 555                 560 


Ala Thr Glu Ala Lys Arg Lys Gln Glu Glu Met Leu Ala Asp Val Gln 
                565                 570                 575     


Lys Ser Leu Glu Ser Leu Asp Asn Gln Ile Asn Glu Glu Ile Glu Asn 
            580                 585                 590         


Val Glu Arg Lys Asn Ser Ser Leu Lys Ser Gly Glu Ile Ala Ser Trp 
        595                 600                 605             


Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln Lys Asp Asn Glu 
    610                 615                 620                 


Gly Asn Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln Met 
625                 630                 635                 640 


Leu Gln Arg Ser Leu Ala Leu Tyr Asn Lys Glu Glu Lys Pro Thr Arg 
                645                 650                 655     


Tyr Phe Lys Gln Val Asn Leu Ile Glu Ser Ser Asn Pro His Pro Phe 
            660                 665                 670         


Leu Asn Asn Thr Glu Trp Glu Lys Cys Asn Asn Ile Leu Ser Phe Tyr 
        675                 680                 685             


Arg Ser Tyr Leu Glu Ala Lys Lys Asn Phe Leu Glu Ser Leu Lys Pro 
    690                 695                 700                 


Glu Asp Trp Glu Lys Asn Gln Tyr Phe Leu Met Leu Lys Glu Pro Lys 
705                 710                 715                 720 


Thr Asn Cys Glu Thr Leu Val Gln Gly Trp Lys Asn Gly Phe Asn Leu 
                725                 730                 735     


Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg Lys Trp Phe Met Glu His 
            740                 745                 750         


Trp Lys Ser Ile Lys Val Asp Asp Leu Lys Arg Val Gly Leu Val Ala 
        755                 760                 765             


Lys Val Ile Pro Leu Phe Phe Ser Glu Glu Tyr Lys Asp Ser Val Gln 
    770                 775                 780                 


Pro Phe Tyr Asn Tyr Leu Phe Asn Val Gly Asn Ile Asn Lys Pro Asp 
785                 790                 795                 800 


Glu Lys Asn Phe Leu Asn Cys Glu Glu Arg Arg Glu Leu Leu Arg Lys 
                805                 810                 815     


Lys Lys Asp Glu Phe Lys Lys Met Thr Asp Lys Glu Lys Glu Glu Asn 
            820                 825                 830         


Pro Ser Tyr Leu Glu Phe Lys Ser Trp Asn Lys Phe Glu Arg Glu Leu 
        835                 840                 845             


Arg Leu Val Arg Asn Gln Asp Ile Val Thr Trp Leu Leu Cys Met Glu 
    850                 855                 860                 


Leu Phe Asn Lys Lys Lys Ile Lys Glu Leu Asn Val Glu Lys Ile Tyr 
865                 870                 875                 880 


Leu Lys Asp Ile Asn Thr Asn Thr Thr Lys Lys Glu Lys Asn Thr Glu 
                885                 890                 895     


Glu Lys Asn Gly Glu Glu Lys Ile Ile Lys Glu Lys Asn Asn Ile Leu 
            900                 905                 910         


Asn Arg Ile Met Pro Met Arg Leu Pro Ile Lys Val Tyr Gly Arg Glu 
        915                 920                 925             


Asn Phe Ser Lys Asn Lys Lys Lys Lys Ile Arg Arg Asn Thr Phe Phe 
    930                 935                 940                 


Thr Val Tyr Ile Glu Glu Lys Gly Thr Lys Leu Leu Lys Gln Gly Asn 
945                 950                 955                 960 


Phe Lys Ala Leu Glu Arg Asp Arg Arg Leu Gly Gly Leu Phe Ser Phe 
                965                 970                 975     


Val Lys Thr Pro Ser Lys Ala Glu Ser Lys Ser Asn Thr Ile Ser Lys 
            980                 985                 990         


Leu Arg Val Glu Tyr Glu Leu Gly  Glu Tyr Gln Lys Ala  Arg Ile Glu 
        995                 1000                 1005             


Ile Ile  Lys Asp Met Leu Ala  Leu Glu Lys Thr Leu  Ile Asp Lys 
    1010                 1015                 1020             


Tyr Asn  Ser Leu Asp Thr Asp  Asn Phe Asn Lys Met  Leu Asn Gly 
    1025                 1030                 1035             


Trp Leu  Glu Leu Lys Asn Lys  Ala Asn Lys Ala Ser  Leu Glu Glu 
    1040                 1045                 1050             


Ala Asn  Lys Ala Arg Phe Gln  Asn Asp Val Asp Leu  Leu Ile Ala 
    1055                 1060                 1065             


Val Arg  Asn Ala Phe Ser His  Asn Gln Tyr Pro Met  Arg Asn Arg 
    1070                 1075                 1080             


Ile Ala  Phe Ala Asn Ile Asn  Pro Phe Ser Leu Ser  Ser Ala Asn 
    1085                 1090                 1095             


Thr Ser  Glu Glu Lys Gly Leu  Asn Ile Ala Asn Gln  Leu Lys Asp 
    1100                 1105                 1110             


Lys Thr  His Lys Thr Ile Glu  Lys Ile Ile Glu Ile  Glu Lys Pro 
    1115                 1120                 1125             


Ile Glu  Thr Lys Glu 
    1130             


<210>  2252
<211>  1145
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2252

Met Glu Thr Leu Thr Ile Pro Glu Val Ile Lys Cys Arg Thr Leu Ser 
1               5                   10                  15      


Asp Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Ile Ala Lys Glu Phe Asp Leu Pro Leu 
        35                  40                  45              


Leu Ala Glu Glu Gly His Leu Lys Asn Ser Phe Leu Cys Lys Lys Glu 
    50                  55                  60                  


His Asn Lys Val Asn Trp Asn His Val Tyr Ser Arg Thr Lys Arg Phe 
65                  70                  75                  80  


Leu Ala Val Leu Lys Val Phe Asp Ala Glu Thr Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Lys Thr Ile Asn Trp Glu Gly Lys Asp Phe Ala Ser Met Ser Asp 
            100                 105                 110         


Ile Leu Lys Ile Val Phe Gly Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Thr Ile Arg Lys Thr Ala Val 
    130                 135                 140                 


Ser Ala Glu Met Ala Leu Phe Leu Thr Thr Asn Phe Arg Arg Ala Ile 
145                 150                 155                 160 


Glu Tyr Thr Lys Glu Arg Phe Lys Gly Val Leu Asn Asp Glu Asp Tyr 
                165                 170                 175     


Gln Leu Val Ala Ser Lys Lys Val Leu Glu Ala Asn Ser Thr Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Arg Phe Ile Gly Ile Ile Thr Gly Leu Lys Gly Thr Gln Asn 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro His Asp Arg Phe Gln Ser Asp Asn Pro Arg Gln Ala Phe Ser 
                245                 250                 255     


Leu Asp Leu Ile Asn Glu Leu Asn Arg Cys Pro Lys Val Leu Tyr Asn 
            260                 265                 270         


Ala Ile Thr Glu Glu Gly Lys Gln Lys Leu Arg Ser Ile Pro Gly Glu 
        275                 280                 285             


Leu Glu Asn Lys Asn Leu His Asp Asn Asn Thr Lys Lys Glu Ala Lys 
    290                 295                 300                 


Ile Glu Ala Glu Ala Tyr Glu Leu Tyr Ile Glu Ser Leu Thr Arg Gln 
305                 310                 315                 320 


Ile Arg Tyr Ser Asn Arg Phe Pro Asp Phe Ala Leu Lys Phe Ile Asp 
                325                 330                 335     


Glu Thr Asp Ile Phe Ser Glu Phe Arg Phe Gln Ile Asp Leu Gly Lys 
            340                 345                 350         


Leu Leu Val Asp Glu Tyr Leu Lys Phe Phe Asn Gly Glu His Val Gln 
        355                 360                 365             


Arg Arg Ile Val Glu Asn Ala Lys Ala Phe Gly Lys Leu Ile Asp Phe 
    370                 375                 380                 


Asn Asp Glu Ala Lys Val Met Thr Arg Ile Gly Asn Gly His Phe Ser 
385                 390                 395                 400 


Lys Arg Phe Glu Gln Phe Ala Pro Phe Tyr Asn Thr Glu Asp Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Arg His His Val Thr Ala Lys Leu Gly Pro Asp Ser 
            420                 425                 430         


Lys Gly Glu Pro Glu Lys Lys Leu Leu Gln Pro Leu Pro Glu Ala Phe 
        435                 440                 445             


Leu Ser Leu His Glu Leu Pro Lys Val Ile Leu Leu Asp Tyr Leu Gln 
    450                 455                 460                 


Lys Gly Glu Pro Glu Lys Leu Ile Asn Asp Phe Ile Leu Ile Asn Asn 
465                 470                 475                 480 


Ser Lys Leu Met Asn Met Ser Phe Ile Glu Ala Val Lys Thr Gln Leu 
                485                 490                 495     


Pro Pro Glu Trp Asp Glu Phe Gln Arg Arg Thr Gly Ser Lys Asn Glu 
            500                 505                 510         


Met Pro Tyr Asn Glu Lys Thr Leu Ala Tyr Leu Leu Gln Arg Lys Gln 
        515                 520                 525             


Ile Leu Asn Lys Ile Leu Ala Glu Phe Gln Leu Asn Asp Lys Gln Ile 
    530                 535                 540                 


Pro Gly Arg Ile Leu Asp Tyr Trp Leu Asn Ile Ala Asp Val Glu Glu 
545                 550                 555                 560 


Glu Arg Ala Val Ser Asp Arg Ile Lys Ser Ile Lys Arg Asp Cys Met 
                565                 570                 575     


Ser Arg Leu Arg Ala Leu Gly Lys Phe Lys Ile Asp Arg Asn Arg Asn 
            580                 585                 590         


Lys Ile Pro Lys Ile Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile 
        595                 600                 605             


Val Asp Met Val Val Ser Glu Gly Lys Lys His Lys Ile Thr Ser Phe 
    610                 615                 620                 


Tyr Tyr Glu Lys Met Gln Asp Cys Leu Ser Leu Phe Ala Asp Pro Leu 
625                 630                 635                 640 


Lys Arg Gln Leu Phe Ile His Ile Ile Thr Asn Glu Leu Arg Leu Asn 
                645                 650                 655     


Asp Ser Gly Gly His Pro Phe Leu Phe Lys Leu Asn Met Arg Gln Ile 
            660                 665                 670         


Asn Cys Thr Ser Asp Phe Tyr Glu Ile Tyr Leu Gln Glu Lys Gly His 
        675                 680                 685             


Lys Met Val Pro Glu Lys Asn Leu Lys Thr Gly Lys Val Val Asn Thr 
    690                 695                 700                 


Asp His Ser Trp Met Ala Leu Thr Phe Tyr Lys Leu Glu Phe Asn Asp 
705                 710                 715                 720 


Lys Val Asp Lys Leu Met Thr Val Val Lys Leu Pro Leu Asn Lys Leu 
                725                 730                 735     


Asn Leu Pro Phe Thr Leu Arg Gln Leu Asn Ala Lys Thr Thr Tyr Thr 
            740                 745                 750         


Leu Glu Gln Trp Leu Lys Asn Leu Thr Leu Gly Lys Lys Pro Asp Asp 
        755                 760                 765             


Gly Lys His Pro Val Asn Leu Pro Thr Asn Leu Phe Asp Glu Lys Leu 
    770                 775                 780                 


Ser Asp Leu Leu Arg Gln Asp Leu Asp Asn Asn Lys Ile Ala Tyr Arg 
785                 790                 795                 800 


Pro Tyr Ala Asn Trp Asn Glu Leu Phe Lys Ile Trp Trp Ile Ser Arg 
                805                 810                 815     


Asn Asp Ser Leu Gln Arg Phe Tyr Asn Ala Glu Arg Glu Tyr His Ile 
            820                 825                 830         


Phe Asn Glu Lys Val Asn Phe Tyr Pro Asn Arg Lys Glu Asn Phe Ala 
        835                 840                 845             


Asp Tyr Tyr Gln His Ala Val Lys Val Ala Phe Gln Lys Lys Arg Asn 
    850                 855                 860                 


Glu Arg Ile Ile Glu Gln Arg Ile Asn Lys Tyr Leu Pro Asp Ile Leu 
865                 870                 875                 880 


Phe Glu Gln Val Glu Lys Thr Phe Lys His Thr Ile Ala Glu Thr Glu 
                885                 890                 895     


Lys Glu Ile Arg Ile Leu Gln Glu Glu Asp Arg Ile Met Leu Leu Met 
            900                 905                 910         


Leu Glu Gly Leu Met Glu Asp Gly Asn Lys Gln Gln Leu Lys Leu Ser 
        915                 920                 925             


Glu Ile Lys Thr Leu Gln Asn Ala Thr Ile Asn Ile Arg Gln Leu Val 
    930                 935                 940                 


Pro Gly Lys Leu Ser Phe Asp Asp Ser Gly Glu Ala Ile Lys Asp Ser 
945                 950                 955                 960 


Thr Asn Pro Glu Ile Val Arg Thr Val Ser Val Ser Ile Lys Arg Ile 
                965                 970                 975     


Glu Tyr Asn Leu Leu Pro Lys Tyr Val Ala Asp Gly Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Pro Asp Glu  Glu Ile Gln Met Glu  Arg Leu Lys 
        995                 1000                 1005             


Thr Glu  Phe Asp Thr Tyr Asn  Lys Val Arg Gln Val  Val Leu Asp 
    1010                 1015                 1020             


Leu Ser  Phe Lys Leu Glu Lys  Met Ile Ile Glu Lys  Gly His Lys 
    1025                 1030                 1035             


Asp Arg  Ile Asn Gln Leu Cys  Thr Gly Ala Thr Gly  Glu Leu Leu 
    1040                 1045                 1050             


Thr Gly  Asn Ile Cys His His  Thr Tyr Leu Thr Trp  Leu Lys Asp 
    1055                 1060                 1065             


Lys Glu  Met Ile Asp Asn Glu  Thr Phe Ile Phe Met  Asn Met Val 
    1070                 1075                 1080             


Gln His  Cys Phe Ser His Asn  Gln Tyr Pro Gln Lys  Lys Thr Met 
    1085                 1090                 1095             


Glu Arg  Ile Ile Asn His Trp  Glu Pro Asp Arg Phe  Ala Leu Thr 
    1100                 1105                 1110             


Ile Ala  Ala Thr Tyr Asn Gln  Lys Ile Ala Gly Ile  Leu Glu Asp 
    1115                 1120                 1125             


Ile Gly  Thr Phe Pro Phe Ile  Arg Ser Arg Lys Thr  Met Pro Asp 
    1130                 1135                 1140             


Val Val  
    1145 


<210>  2253
<211>  1156
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2253

Met Glu Ser Gln Pro Lys Arg Thr Asp Gly Ile Thr Tyr Tyr Asp His 
1               5                   10                  15      


Lys Ser Asn Ser Asp Lys His Tyr Phe Gly Gly Tyr Leu Asn Gln Ala 
            20                  25                  30          


Leu Asn Asn Tyr Thr Val Ile Glu Lys Leu Phe Glu Gln Lys Phe Glu 
        35                  40                  45              


Glu Ser Leu Glu Asn Phe Leu Gln Lys Asn Lys Lys Val Ser Tyr Ala 
    50                  55                  60                  


Gln Trp Glu Arg Met Leu Asn Phe Leu Lys His His Phe Pro Val Val 
65                  70                  75                  80  


His Tyr Ile Asp Leu Pro Val Arg Glu Ala Thr Lys Asp Asn Pro Asp 
                85                  90                  95      


Pro Phe Pro Arg Asn Asp Ala Glu Arg Arg Gln His Phe Ile Thr Thr 
            100                 105                 110         


Phe Thr Ser Ile Lys Lys Leu Leu Phe Asp Leu Arg Asn Phe Tyr Ser 
        115                 120                 125             


His Tyr Phe His Glu Pro Ile Asp Thr Lys Ile Asp Thr Leu Ser His 
    130                 135                 140                 


Leu Asp Gln Ile Phe Val Ala Val Cys Glu His Val Lys Thr Lys Arg 
145                 150                 155                 160 


Met Lys Thr Asp Glu Thr Arg Leu Leu Leu Lys Glu Thr Leu Ala Asp 
                165                 170                 175     


Glu Leu Thr His Leu Phe Ile Leu Lys Glu Lys Glu Leu Leu Glu Leu 
            180                 185                 190         


Lys Lys Lys Val Gly Ile Thr Gly Lys Thr Thr Ala Glu Glu Val Arg 
        195                 200                 205             


Asn Ala Ile Phe Asn Asp Ser Phe Lys His Leu Tyr Tyr Glu Lys Gln 
    210                 215                 220                 


Pro Ser Arg Ile Tyr Arg Ser Ser Leu Gln Glu Glu Ala Ala Thr Glu 
225                 230                 235                 240 


Asn Gly Ile Thr Ile Ser Gln Ser Gly Leu Ser Leu Ile Leu Ser Phe 
                245                 250                 255     


Phe Leu Ser Lys Arg Glu Met Glu Gly Phe Lys Ser Arg Leu Arg Gly 
            260                 265                 270         


Leu Lys Gly Arg Val Leu Asn Leu Glu Asn Gly Asn Ile Asp Leu Arg 
        275                 280                 285             


Asn Asn Ser Leu Arg Phe Met Ala Thr His Trp Val Phe Ser Tyr Leu 
    290                 295                 300                 


Cys Phe Lys Gly Pro Asn Gln Lys Leu Asn Thr Ser Tyr Leu Glu Glu 
305                 310                 315                 320 


Thr Leu Leu Val Gln Ile Ile Asp Glu Leu Thr Lys Val Pro His Glu 
                325                 330                 335     


Val Tyr Glu Ala Leu His Val Val Gln Arg Asp Lys Phe Val Glu Asp 
            340                 345                 350         


Ile Asn Glu Phe Met Arg Gln Asp Leu Glu Asp Gly Ser Glu Glu Asn 
        355                 360                 365             


Ala Leu Val Val His Pro Val Ile Arg Lys Arg Cys Glu Asn Lys Phe 
    370                 375                 380                 


Asn Tyr Phe Ala Leu Arg Tyr Leu Asp Glu Phe Ala Gly Phe Lys Thr 
385                 390                 395                 400 


Leu Arg Phe Gln Ile Asn Ile Gly Asn Tyr Ile His Asp Arg Arg Ser 
                405                 410                 415     


Lys Glu Leu Lys Ser Gly Ser Phe Ile Thr Asp Arg Glu Val Lys Glu 
            420                 425                 430         


Arg Ile Asn Val Phe Gly Arg Leu Ser Ala Val Thr Thr Leu Lys Asp 
        435                 440                 445             


Asp Phe Phe Arg Ser Glu Ser Tyr Glu Gly Ser Ser Trp Glu Arg Phe 
    450                 455                 460                 


Pro Asn Pro Ser Tyr Asn Ile Asn Gly Asn Asn Ile Ala Ile Tyr Leu 
465                 470                 475                 480 


Asp Leu Gly Lys Asp His Gly Lys Asp Thr Lys Val Ile Tyr Asp Ala 
                485                 490                 495     


Arg Ser Lys Arg Asn Lys Lys Glu Glu Arg Val Asp Arg Ser Asn Gly 
            500                 505                 510         


Lys Pro Thr Lys Asp Asp Ile Leu Lys Glu Leu Gln Gln Ala Val Glu 
        515                 520                 525             


Val Lys Ser Asp Thr Ile His Arg Lys Glu Pro Thr Ala Leu Leu Ser 
    530                 535                 540                 


Leu His Glu Leu Pro Ala Leu Leu Tyr Glu Leu Leu Val Asn His Val 
545                 550                 555                 560 


Lys Pro Glu Thr Ile Glu Thr Ile Leu Ala Gly Lys Ile Ser Glu Arg 
                565                 570                 575     


Leu Lys Val Ile Gln Glu Tyr Thr Pro Gln Ser Asp Leu Pro Leu Ser 
            580                 585                 590         


Gln Ile Pro Lys Asn Leu Lys Val Ser Gly Gln Glu Pro Lys Val Gln 
        595                 600                 605             


Tyr Asp Lys Leu Ile Arg Leu Ile Asp Asn Leu Ile Ala Ala Gly Glu 
    610                 615                 620                 


Asp Lys Ser Ala Leu Ile Ser Lys Asn Gln Arg Glu Ile Ala Asn Pro 
625                 630                 635                 640 


Lys Ile Lys Arg Asn Phe Val Phe Thr Ile Thr Glu Arg Gly Arg Glu 
                645                 650                 655     


Ala Asn Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Glu Ser Thr 
            660                 665                 670         


Lys Gly Gln Trp Lys Gly Tyr His His Ser Gln Leu Gln Glu Ile Leu 
        675                 680                 685             


Ala Phe Tyr Phe Ala Arg Lys Gln Asp Ala Ile Ser Leu Leu Asn Ser 
    690                 695                 700                 


Val Trp Gln Leu Lys Gln Ser Asp Phe Gly Ala Ser Leu Glu Val Leu 
705                 710                 715                 720 


Phe Leu Lys Pro Gly Phe Asp Ser Phe Tyr Ile Ala Tyr Leu Gln Asn 
                725                 730                 735     


Arg Lys Glu His Leu Gly Gln Ile Arg Asp Arg Ile Leu Gln Tyr Gln 
            740                 745                 750         


Ser Glu Lys Asn Val Ile Lys Lys Val Leu Lys Ser Ile Asp His Ile 
        755                 760                 765             


Phe Pro Lys Lys Val Tyr Thr Ile Arg Ser Thr Gln Asp Gln Ile Glu 
    770                 775                 780                 


Asn Leu Leu Gly Lys Pro Ile Ala Phe Ser Arg Gly Ile Phe Asp Ser 
785                 790                 795                 800 


Lys Pro Thr Phe Ile Thr Asp Thr Thr Phe Glu Gly Asn Glu His Leu 
                805                 810                 815     


Phe Ala Asp Trp Tyr Arg Thr Ser Arg Asp Lys Ser Ile Ala Phe Gln 
            820                 825                 830         


Ser Phe Tyr Asn Leu Pro Lys Asp Tyr Ser Glu Leu Ile Ser His Ala 
        835                 840                 845             


Lys Glu Thr Gly Lys Arg Ile His Asp Leu Ser Ala Arg Val Lys Met 
    850                 855                 860                 


Asn Thr Asp Leu Asn Ile Lys Asn Val Gln Ile Lys Asp Phe Phe Leu 
865                 870                 875                 880 


Lys Lys Ile Ala Asp Ala Leu Phe Gln Lys Cys Leu Gly Gln Thr Phe 
                885                 890                 895     


Ala Asn Ser Glu Gly Asn Asp Leu Ala Asn Leu Thr Leu Glu Gln Leu 
            900                 905                 910         


Tyr Leu Glu Arg Glu Glu Arg Lys Gln Ile Asn Leu Asn Ala Lys Leu 
        915                 920                 925             


Gln Tyr Gln Arg Lys Pro Gly Ser Leu Ser Asn Asn Ile Tyr Asn Asp 
    930                 935                 940                 


Ser Phe Ile Trp Asn Lys Pro Ile Gln Phe Lys Ala Asp Gln Ile Glu 
945                 950                 955                 960 


Glu Ser Lys Val Lys Leu Lys Asp Leu Gly Lys Ile Lys Arg Phe Ile 
                965                 970                 975     


Ala Asp Thr Lys Val Thr Gln Leu Leu Ala Tyr Ala Pro Thr Arg Val 
            980                 985                 990         


Trp Ser Ile Gly Glu Leu Glu Asp  Glu Leu Asn Leu Lys  Ala Arg Cys 
        995                 1000                 1005             


Tyr Glu  Thr Ile Arg Arg Glu  Gln Ile Leu Lys Asp  Leu Phe Asn 
    1010                 1015                 1020             


Phe Glu  Lys Gln Ile Leu Thr  Ser Leu Asn Phe Asn  Gly Gln Val 
    1025                 1030                 1035             


Glu Pro  Pro Ser Leu Ala Ile  His Thr Asn His Lys  Phe Arg Ala 
    1040                 1045                 1050             


Tyr Val  Ala Glu Gly Val Leu  Arg Arg Lys Gly His  Ile Glu Ser 
    1055                 1060                 1065             


Ala Ser  Trp Leu Ile Asn Ile  Asp Phe Glu Lys Thr  Gly Val Lys 
    1070                 1075                 1080             


Glu Leu  Arg Glu Ala Thr Ser  Leu Ser Ile Asp Ser  Phe Leu Leu 
    1085                 1090                 1095             


Val Leu  Ile Arg Asn Lys Phe  Met His Asn Gln Leu  Pro Pro Leu 
    1100                 1105                 1110             


Pro Phe  Tyr Glu Phe Met Cys  Glu Arg Tyr Pro Lys  Asn Glu Gly 
    1115                 1120                 1125             


Glu Thr  Phe Ser Glu Phe Phe  Phe Arg Ile Ala Ala  Ala Ile Met 
    1130                 1135                 1140             


Lys Lys  Leu Ile Asn Leu Asp  Val Lys Ile Ala Val  Ala 
    1145                 1150                 1155     


<210>  2254
<211>  1129
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2254

Met Glu Thr Asn Gln Gln Thr His Glu Asn Arg Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Asn Asn His Val Ala Thr Asp Phe Lys Arg Lys Pro 
        35                  40                  45              


Leu Pro Glu Glu Gly His Ile Pro Asp Ala Leu Leu Cys Asn Lys Thr 
    50                  55                  60                  


Ile Lys Asn Leu Asn Trp Asn His Val His Thr Arg Ala Leu Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ser Glu Ser Leu Pro Lys Asp Glu 
                85                  90                  95      


Arg Glu Asn Ser Asp Thr Glu Gly Lys Asp Phe Thr Ser Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Ser Glu Leu Gln Asp Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Asp Ser Arg Lys Leu Ile Val 
    130                 135                 140                 


Ser Pro Glu Leu Ala Asn Phe Leu Thr Val Asn Phe Gln Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Ala Arg Met Lys Asp Val Leu Thr Asp Thr Asp Tyr 
                165                 170                 175     


Ala Leu Val Glu Asn Leu Gln Met Val Ala Pro Asp Asn Lys Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ala Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Thr Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asn Leu Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Ser 
            260                 265                 270         


Val Ile Thr Asp Lys Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Asp Asp Glu Arg 
    290                 295                 300                 


Glu Thr Ile Leu Asp Glu Ile Asp Tyr Gln Asp Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg Tyr Ser Asp Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Asp Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Asn Tyr Thr Lys Gln Phe Ala Gly Glu 
        355                 360                 365             


Gln Ala Glu Arg Lys Val Leu Glu Asn Ala Asn Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asp Pro Glu Leu Ile Gln Gln Arg Ile Asp Lys Gln 
385                 390                 395                 400 


Gln His Thr Ala Gly Phe Asp Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Thr Lys Glu Asn Ile Ala Thr Leu Ile 
            420                 425                 430         


Ala Lys Ser Lys Ala Ser Ser Lys Val Glu His Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Gln Ala Glu Glu Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Ile Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Ser Gln Leu Pro Ala Asn Trp Asp Glu Phe Ser Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asp Ser Thr Leu Lys Tyr Leu 
        515                 520                 525             


Arg Gln Arg Lys Thr Thr Leu Asn Thr Ile Leu Ser Lys Ser Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Lys Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Thr Arg Leu Lys Ala Val Glu Lys His Lys Leu 
            580                 585                 590         


Asn Lys Ser Val Lys Ile Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Glu Glu Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Ala Asn Ala Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Phe Glu Asn Gly Gly His Pro Phe Leu Gln Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Gln Ala Tyr Leu Val 
        675                 680                 685             


Glu Lys Gly Asn Lys Met Val Pro Arg Leu Asn Pro Lys Thr Asn Lys 
    690                 695                 700                 


Thr Ser Lys Val Asp Glu Ser Trp Met Met Lys Gln Phe Tyr Val Lys 
705                 710                 715                 720 


Glu Trp Lys Glu Glu Ile Ala Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Ser Arg Ile Pro Phe Thr Ile Arg Gln Trp Asp Glu Lys 
            740                 745                 750         


Glu Lys Tyr Asp Leu Asn Val Trp Leu Gln His Val Thr Val Gly Lys 
        755                 760                 765             


Asn Lys Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe Asp 
    770                 775                 780                 


Glu Ala Leu Cys Asn Leu Leu Arg Glu Gln Leu Asp Thr Lys Ile Val 
785                 790                 795                 800 


Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Ile Trp Trp 
                805                 810                 815     


Lys Thr Arg Asn Asp Asp Thr Gln Gln Phe Tyr Gln Ser Glu Arg Glu 
            820                 825                 830         


Tyr Asp Ile Tyr Asn Glu Lys Val Arg Phe Lys Ile Asp Ser Ser Thr 
        835                 840                 845             


His Phe Ala Asp Tyr Tyr Lys Asn Ala Leu Ser Arg Ala Tyr Thr Arg 
    850                 855                 860                 


Leu Lys Ala Glu Arg Glu Thr Ala Arg Gln Thr Asn Lys Arg Leu Pro 
865                 870                 875                 880 


Pro Leu Glu Tyr Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile Ala 
                885                 890                 895     


Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met Ala 
            900                 905                 910         


Val Leu Met Leu Glu Gln Leu Met Asp Asn Ser Pro Asn Leu Arg Leu 
        915                 920                 925             


Ser Lys Ile Glu Thr Leu Leu Asn Asp Thr Thr Pro Ile Ser Glu Lys 
    930                 935                 940                 


Ile Ser Ala Lys Leu Ser Phe Asp Ala Ser Gly Glu Arg Ile Thr Asp 
945                 950                 955                 960 


Lys Ser Asn Pro Thr Ala Thr Lys Thr Leu Val Ala Glu Arg Lys Gln 
                965                 970                 975     


Lys Asn Tyr Thr Glu Leu Gln Lys Tyr Arg Tyr Asp Arg Arg Leu Pro 
            980                 985                 990         


Glu Leu Phe Glu Tyr Val Gln Ala  Asp Glu Ile Pro Leu  Glu Trp Leu 
        995                 1000                 1005             


Leu Asp  Glu Leu Ser Ala Tyr  Asn Ser Ala Lys Gln  Gln Val Phe 
    1010                 1015                 1020             


Asp Thr  Val Phe Ala Leu Glu  Lys Lys Ile Ile Gln  Thr Glu Pro 
    1025                 1030                 1035             


Asp Glu  Leu Lys Ser Leu Phe  Thr Gly Ala Asn Gly  Glu Leu Gln 
    1040                 1045                 1050             


Thr Gly  Asn Ile Gln His Lys  Pro Tyr Val Gln Trp  Leu Thr Asn 
    1055                 1060                 1065             


Lys Gly  Leu Ile Asn Lys Glu  Glu Lys Gln Phe Ile  Asn Met Val 
    1070                 1075                 1080             


Arg Lys  Cys Phe Ser His Asn  Gln Phe Pro Gln Arg  Thr Thr Met 
    1085                 1090                 1095             


Glu Leu  Leu Ile Pro Ala Trp  Asn Glu Lys Lys Leu  Ala Leu Gln 
    1100                 1105                 1110             


Ile Ala  Thr Val Tyr Asn Gln  Leu Ile Ala Asp Leu  Thr Asp Lys 
    1115                 1120                 1125             


Ile 
    


<210>  2255
<211>  1130
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2255

Met Glu Thr His Thr Glu Arg Val Ser Val Thr Tyr Asp Tyr Thr Glu 
1               5                   10                  15      


Lys Ala Asp Lys His Tyr Phe Ala Gly Phe Leu Asn Gln Ala Asp Leu 
            20                  25                  30          


Asn Phe Arg Thr Ala Leu Val Glu Leu Ala Lys Arg Cys Gly Ile Glu 
        35                  40                  45              


His Gly Val Asn Arg Ala Asn Glu Gly Gln Asn Asp Glu Lys Glu Thr 
    50                  55                  60                  


Ile Ser Trp Ile Asn Glu Thr Phe Asn Asp Lys Leu Ser Gln Thr Asp 
65                  70                  75                  80  


Trp Asn Tyr Arg Thr Ser Leu Leu Ser Asn Phe Leu Pro Phe Val Arg 
                85                  90                  95      


Glu Ile Ser Tyr Lys Glu Asn Thr Ser Val Thr Arg Asp Ala Phe Arg 
            100                 105                 110         


Ser Asp Leu Ile Leu Leu Tyr Glu Asn Leu Met Ile Leu Arg His Tyr 
        115                 120                 125             


Tyr Thr His Lys Phe His Asp Glu Lys Lys Leu Glu Arg Lys Val Phe 
    130                 135                 140                 


Gly Val Leu Asp Tyr Leu Ile Leu Gln Ala Ala His Thr Val Arg Asn 
145                 150                 155                 160 


Arg Arg Leu Arg Asn Ala Ile Tyr Lys Pro Ala Leu Pro Lys Gln Phe 
                165                 170                 175     


Glu Glu Asp Tyr Leu Glu Ala Glu Lys Ser Phe Ile Lys His Asn Gln 
            180                 185                 190         


Glu Val Glu Ala Leu Arg Gln Thr Glu Lys Leu Lys Ala Asp Phe Asp 
        195                 200                 205             


Ile Lys Gln Phe Arg Lys Lys His Pro Thr Tyr Lys Glu Glu Asp Phe 
    210                 215                 220                 


His Ser Ile Tyr Leu Asn Arg Ala Val Ser Glu Ile Leu Asp Lys Asn 
225                 230                 235                 240 


Lys Asp Thr Gly Glu Phe Ser Leu Lys Asp Ser Gln Arg Ser Glu Arg 
                245                 250                 255     


Ala Glu Lys Asp Asp Lys Leu Ser Gln Asn Gly Phe Val Phe Phe Leu 
            260                 265                 270         


Cys Leu Phe Leu Ser Arg Lys Asp Ala Glu Asp Leu Leu Asp His Thr 
        275                 280                 285             


Thr Asn Phe Lys Ala Ser Tyr Arg Leu Arg Tyr Leu Val Lys Arg Trp 
    290                 295                 300                 


Thr Tyr Thr Val Phe Cys Tyr Val Gly Ile Arg His Thr Leu Arg Ser 
305                 310                 315                 320 


Glu Phe Ser Lys Glu Ala Leu Leu Leu Gln Met Val Asp Glu Leu Ser 
                325                 330                 335     


Lys Cys Pro Ala Glu Leu Phe Glu Val Leu Pro Glu Asp Lys Gln Gln 
            340                 345                 350         


Glu Phe Val Met Asp Arg Asn Glu Tyr Phe Lys Asp Asn Asp Glu Asp 
        355                 360                 365             


Gly Asn Thr Pro Glu Glu Ser Phe Val Ser His Leu Ile Ile Arg Lys 
    370                 375                 380                 


Arg Tyr Gln Asp Arg Phe Pro Tyr Phe Ala Ile Arg Phe Leu Asp Glu 
385                 390                 395                 400 


Phe Ala Asn Phe Gln Ser Leu Arg Phe Gln Leu Arg Leu Gly Lys Tyr 
                405                 410                 415     


Lys His Asp Thr Arg Thr Lys Thr Phe Lys Gly Ile Glu Thr Thr Thr 
            420                 425                 430         


Glu Arg Ser Ile Lys Glu Glu Ile Lys Val Phe Gly Lys Leu Ser Glu 
        435                 440                 445             


Val His Lys Ser Lys Glu Glu Tyr Phe Glu Ala Lys Pro Glu Ala Asp 
    450                 455                 460                 


Glu Lys Thr Ile Lys Gly Trp Leu Gln Tyr Pro Asn Val Ser Tyr Val 
465                 470                 475                 480 


Ile Asp Asn Asn Asn Ile Pro Ile Tyr Leu Asp Lys Phe Thr Gln Lys 
                485                 490                 495     


Glu Asn Phe Pro Ile Asp Arg Ser Arg Lys Ile Glu Ile Ile Asn Glu 
            500                 505                 510         


Leu His Ile Asn Glu Ile Ile Arg Ser Glu Ala Pro His Ala Phe Leu 
        515                 520                 525             


Ser Ile Asn Glu Leu Pro Ala Cys Ile Tyr Leu Phe Met Glu Glu Ala 
    530                 535                 540                 


Ser Lys Lys Lys Arg His Pro Asn Ser Glu Arg Glu Leu Leu Thr Asn 
545                 550                 555                 560 


Pro Ile Gly Val Gly Ile Glu Asn Arg Ile Leu Gly Lys Val Gln Ser 
                565                 570                 575     


Gln Tyr Lys Phe Ile Gln Thr Val Asp Tyr Asn Ser Gln Leu Ser Asp 
            580                 585                 590         


Lys Asn Thr Pro Lys Arg Phe Ile Lys Ser Leu Lys Glu Gly Lys Thr 
        595                 600                 605             


Asn Gly Glu Ile Asp Tyr His Arg Leu Thr Asn Ala Ile Lys Lys Gln 
    610                 615                 620                 


Ile Glu Asp Cys Asp Gln Arg Leu Ile Trp Leu Asn Ser Lys Lys Glu 
625                 630                 635                 640 


Glu Gln Lys Asn Arg Glu Lys Lys Asp Gln Asn Thr Leu Lys Ser Arg 
                645                 650                 655     


Phe Ile Leu Asn Ser Lys Glu Ile Gly Glu Thr Ala Met Trp Leu Ala 
            660                 665                 670         


Lys Asp Ile Lys Arg Tyr Val Ser Lys Thr Asp Arg Lys Asn Trp Lys 
        675                 680                 685             


Ser Arg His Gln Ala Glu Leu Gln Ala Leu Phe Ala Phe Tyr Asp Lys 
    690                 695                 700                 


Lys Lys Gln Gln Thr Glu Ser Leu Leu Arg Asp Glu Met Gly Ile Asp 
705                 710                 715                 720 


Leu Ser Glu Tyr Ser Phe Leu Lys Asp Met Phe Leu Glu Pro Ser Phe 
                725                 730                 735     


Val Ser Val Tyr Asn Phe Tyr Leu Ile Lys Lys Arg Glu Leu Leu Asn 
            740                 745                 750         


Ser Tyr Val Leu Leu Ile Glu Asn Asn Thr Gly Asn Tyr Gln Gln Lys 
        755                 760                 765             


Ala Val Arg Lys Glu Ile Asn Lys Ile Phe Asp His Phe Asp Arg Ser 
    770                 775                 780                 


Lys Tyr Ser Tyr Ile Asp Ser Ala Tyr His Ser Asn Leu Leu Gln Lys 
785                 790                 795                 800 


Pro Val Asn Leu Pro Arg Gly Leu Phe Asp Asp Lys Lys Glu Phe Ser 
                805                 810                 815     


Ser Lys Gly Asp Lys Glu Gly Arg Gln Ser Trp Phe Ala Leu Ala Glu 
            820                 825                 830         


Asp Ala Pro Lys Gln Val Phe Tyr Ser Tyr Ser Arg Ala Tyr Gln Ile 
        835                 840                 845             


Gln Asp Met Asp Gly Lys Thr Ile Lys Met Lys Glu Phe Glu Met His 
    850                 855                 860                 


Glu Asn Ile Asn Glu Lys Ala Asp Phe Asp Thr Glu Leu Lys Lys His 
865                 870                 875                 880 


Ile Val Thr Thr Glu Lys Arg Ile Arg Lys Ile Ala Arg Gln Asp Tyr 
                885                 890                 895     


Tyr Leu Leu Gln Met Val Lys Phe Leu Phe Glu Glu Leu Gly Ile Lys 
            900                 905                 910         


Phe Thr Glu Asp Ile Thr Leu Ser Asp Ala Phe Phe Glu Arg Asp Asn 
        915                 920                 925             


Ile Arg Lys Asn Ile Gln Ile Ser His Gly Gln Ser Lys Arg Glu Lys 
    930                 935                 940                 


Gly Asp Tyr Ser Glu Asn Ile Tyr Arg Val Ser Asn Leu Leu Glu Thr 
945                 950                 955                 960 


Arg Ile Asn Ile Asn Leu Phe Gly Gly Lys Ile Pro Val Met Asn Ile 
                965                 970                 975     


Arg Leu Lys Asp Val Gly Lys Tyr Arg Ala Leu Glu Lys Asp Glu Arg 
            980                 985                 990         


Ile Lys Lys Leu Leu Ser Tyr Ser  Asp Arg Asn Tyr Ser  Thr Ile Asp 
        995                 1000                 1005             


Glu Leu  Ile Lys Glu Ile Asp  Asn Tyr Glu Tyr Ile  Arg Arg His 
    1010                 1015                 1020             


Glu Ile  Leu Lys Ala Val His  Lys Leu Glu His Thr  Ile Tyr Thr 
    1025                 1030                 1035             


Leu Ala  Lys Glu Asn Asn Glu  Thr Asp Lys Leu Gln  Asp Gly Asn 
    1040                 1045                 1050             


Pro Asn  Phe Thr Glu Tyr Leu  Lys Tyr Tyr Tyr Ser  Gln Ile Asn 
    1055                 1060                 1065             


Glu Ala  Ile Ala Asn Ile Ser  Asp Asp Pro Leu Ile  Ile Val Arg 
    1070                 1075                 1080             


Asn Arg  Leu Ser His Asn Gln  Leu Pro Glu Leu Ser  Glu Tyr Asn 
    1085                 1090                 1095             


Ile Ile  Lys Ala Gln Ser Pro  Arg Asn Glu Thr Glu  Leu Ile Gly 
    1100                 1105                 1110             


Asp Tyr  Leu Leu Arg Val Phe  Asn Ser Phe Asn Asn  Ser Leu Ile 
    1115                 1120                 1125             


Ser Met  
    1130 


<210>  2256
<211>  1150
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2256

Met Glu Thr Gln Met Leu Gly Ile Ser Tyr Asp His Thr Lys Thr Ala 
1               5                   10                  15      


Asp Lys His Phe Phe Gly Gly Tyr Leu Asn Leu Ala Thr Asn Asn Ile 
            20                  25                  30          


Glu Ser Val Ile Asn Ala Phe Arg Asp Lys Phe Gly Pro Lys Asp Lys 
        35                  40                  45              


Glu Leu Gln Ser Ser Gln Phe Ala Ser Val Cys Phe Lys Asp Asn Asp 
    50                  55                  60                  


Ser Asp Ala Asp Phe Gln Lys Lys Phe Arg Phe Ile Gln Met His Phe 
65                  70                  75                  80  


Pro Val Ile Ser Tyr Leu Gln Lys Glu Gly Asp Arg Ser Ile Leu Arg 
                85                  90                  95      


Asn Asn Phe Ser Leu Leu Leu Asn Val Ile Ser Asp Leu Arg Asn Phe 
            100                 105                 110         


Tyr Thr His Tyr Tyr His Lys Pro Leu Glu Phe Pro Asn Glu Leu Phe 
        115                 120                 125             


Ala Leu Leu Asp Phe Val Phe Gly Lys Val Ala His Glu Val Lys Gln 
    130                 135                 140                 


Tyr Lys Met Lys Asp Asp Asn Thr Arg His Leu Leu Asn Lys Asn Leu 
145                 150                 155                 160 


Ser Glu Glu Leu Glu Ile Arg Tyr Gln Gln Gln Phe Glu Lys Leu Arg 
                165                 170                 175     


Glu Leu Lys Asp Gln Gly Lys Lys Ile Asn Leu Ser Asp Thr Thr Gly 
            180                 185                 190         


Ile Lys Asn Gly Val Leu Asn Asn Ala Phe Ser His Leu Ile Phe Lys 
        195                 200                 205             


Asp Gly Glu Asn Phe Lys Pro Thr Val Ser Tyr Ser Ser Tyr Tyr His 
    210                 215                 220                 


Gly Val Asp Ser Ser Lys Asn Gly Ile Thr Ile Ser Gln Ser Gly Leu 
225                 230                 235                 240 


Leu Phe Leu Leu Ser Met Phe Leu Asn Lys Arg Glu Thr Glu Asn Leu 
                245                 250                 255     


Lys Ser Arg Val Arg Gly Phe Lys Ala Lys Ile Ile Lys Ser Glu Glu 
            260                 265                 270         


Asn Glu Ile Ser Gly Leu Lys Phe Met Ala Thr His Trp Val Phe Ser 
        275                 280                 285             


Tyr Leu Ala Phe Lys Gly Val Lys Gln Arg Leu Asn Phe Asp Phe Gln 
    290                 295                 300                 


Glu Glu Thr Leu Leu Val Gln Ile Ile Asp Glu Leu Ser Lys Val Pro 
305                 310                 315                 320 


Asp Glu Leu Tyr Gln Ser Phe Asp Glu Arg Thr Lys Lys Ser Phe Ile 
                325                 330                 335     


Glu Asp Ile Asn Glu Tyr Met Lys Glu Gly Thr Glu Asp Leu Thr Leu 
            340                 345                 350         


Glu Asp Ser Ile Val Val His Pro Val Ile Arg Lys Arg Tyr Glu Asn 
        355                 360                 365             


Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe Met Glu Phe 
    370                 375                 380                 


Pro Thr Leu Arg Phe Gln Val His Val Gly Asn Tyr Val His Asp Arg 
385                 390                 395                 400 


Arg Val Lys Asn Ile Ala Gly Thr Gly Phe Gln Thr Glu Arg Val Leu 
                405                 410                 415     


Lys Asp Arg Ile Lys Val Phe Gly Lys Leu Thr Glu Ile Asn Asn Leu 
            420                 425                 430         


Lys Ala Asp Tyr Ile Glu Lys Glu Leu Lys Leu Ser Asn Glu Ile Gly 
        435                 440                 445             


Trp Glu Leu Leu Pro Asn Pro Ser Tyr Val Phe Ile Glu Asn Asn Ile 
    450                 455                 460                 


Pro Ile Tyr Leu Ser Met Gly Lys Glu Phe Lys Lys Gly Ile Lys Asp 
465                 470                 475                 480 


Phe Ser Asn Arg Arg Lys Ala Gln Lys Pro Glu Glu Met Lys Asn Arg 
                485                 490                 495     


Asn Gln Glu Lys Ile Arg Lys Asp Gln Ile Thr Gly Ile Ile Gly Asn 
            500                 505                 510         


Lys Asn Glu Leu Asn Pro Glu Lys Pro Val Ala Met Leu Ser Leu Asn 
        515                 520                 525             


Glu Ile Pro Ala Leu Leu Tyr Glu Ile Leu Ile Asn Gly Ala Ser Pro 
    530                 535                 540                 


Ser Glu Ile Glu Asn Thr Ile Gln Asp Lys Leu Asn Ala Ala Phe Glu 
545                 550                 555                 560 


Arg Ile Lys Asp Tyr Asp Pro Lys Ser Pro Val Pro Ala Ser Gln Ile 
                565                 570                 575     


Ser Lys Arg Leu Arg Lys Asn Asn Gly Ile Arg Ser Ile Asp Pro Asp 
            580                 585                 590         


Lys Leu Val His Leu Ile Lys Lys Glu Ile Glu Cys Thr Glu Ala Lys 
        595                 600                 605             


Leu Ser Leu Ile Asp Gln Asn Arg Lys Glu Cys Lys Gln Arg Leu Lys 
    610                 615                 620                 


Gly Lys Leu Ile Arg Glu Arg Val Phe Arg Asn Ser Glu Met Gly Arg 
625                 630                 635                 640 


Glu Ala Thr Trp Ile Ala Glu Asp Ile Lys Arg Phe Met Pro Ala Leu 
                645                 650                 655     


Gln Arg Gln Asn Trp Lys Ala Tyr Gln His Ala Gln Phe Gln Gln Ser 
            660                 665                 670         


Leu Ser Tyr Leu Glu Lys Arg Pro Gly Glu Ala Arg Ser Ile Leu Met 
        675                 680                 685             


Glu Gly Trp Asp Phe Glu Asp Gly Ser Ser Leu Trp Asn Gly Trp Ile 
    690                 695                 700                 


Met Asn Cys Phe Thr Lys Asp Leu Pro Phe Asp Val Phe Tyr Glu Phe 
705                 710                 715                 720 


Tyr Leu Lys Lys Arg Lys Glu Tyr Phe Val Gln Leu Leu Asp Asn Ile 
                725                 730                 735     


Lys His Tyr Ser Thr Asn Val Arg Phe Leu Leu Lys Phe Leu Glu Gln 
            740                 745                 750         


Gln Met Pro Lys Gly Leu Phe Asp Lys Arg His Phe Val Leu Glu Asp 
        755                 760                 765             


Leu Glu Thr Glu Lys Asn Lys Ile Leu Ser Lys Pro Leu Val Phe Pro 
    770                 775                 780                 


Arg Gly Ile Phe Asp Asn Lys Pro Thr Phe Ile Lys Gly Lys Lys Val 
785                 790                 795                 800 


Thr Glu Glu Pro Glu Leu Phe Ala Asn Trp Tyr Gln Tyr Gly Tyr Asp 
                805                 810                 815     


Asn Ser His Lys Phe Gln Arg Phe Tyr Asp Trp Glu Arg Asp Tyr Glu 
            820                 825                 830         


Lys Leu Leu Glu Asp Lys Leu Asn Glu Asp Ala Glu Phe Ala Lys Lys 
        835                 840                 845             


Ser Leu Glu Tyr Ser Arg Ala Asp Gln Leu Ala Leu Leu Lys Leu Lys 
    850                 855                 860                 


Gln Asp Leu Lys Ile Lys Lys Ile Lys Ile Glu Asp Leu Phe Leu Lys 
865                 870                 875                 880 


Leu Met Ala Glu Tyr Leu Phe Lys Lys Ile Phe His Tyr Glu Thr Asn 
                885                 890                 895     


Leu Ser Leu Asp Asp Phe Phe Leu Thr Gln Glu Glu Arg Leu Gln Lys 
            900                 905                 910         


Glu Arg Glu Ala Ala Gln Gln Asn Gln Arg Gln Ala Gly Asp Asp Ser 
        915                 920                 925             


Pro Asn Ile Ile Lys Asp Asp Phe Ile Trp Ser Lys Thr Ile Ala Tyr 
    930                 935                 940                 


Gln Lys Gly Gln Ile Tyr Glu Pro Ser Val Lys Leu Lys Asp Phe Gly 
945                 950                 955                 960 


Lys Phe Lys Ala Tyr Ser Ser Asp Glu Lys Val Lys Ala Leu Leu Ser 
                965                 970                 975     


Tyr Asp Thr Asn Lys Ile Trp Cys Lys Leu Glu Leu Glu Lys Glu Leu 
            980                 985                 990         


Ser Ile Gly Ser Leu Cys Tyr Glu  Ala Ile Arg Arg Glu  Gln Leu Phe 
        995                 1000                 1005             


Asn Glu  Ile Gln Glu Leu Glu  Lys Lys Ile Leu Ser  Asn Trp Asn 
    1010                 1015                 1020             


Trp Asp  Lys Ile Asn His Pro  Tyr Glu Phe Glu Val  Glu Asp Lys 
    1025                 1030                 1035             


Lys Gly  Val Gly His Pro Asn  Phe Lys His Tyr Ile  Val Asn Gly 
    1040                 1045                 1050             


Ile Leu  Arg Lys Asn Asn Ile  Val Phe Asn Glu Gly  Glu Asp Gln 
    1055                 1060                 1065             


Trp Ile  Glu Asp Leu Asn Glu  Asn Gln Phe Lys Thr  Leu Ser Lys 
    1070                 1075                 1080             


Glu Glu  Leu Ala Glu Lys Ser  Glu Ile Ile Gln Ile  Ala Phe Leu 
    1085                 1090                 1095             


Ile Ile  Leu Ile Arg Asn Gln  Phe Ala His Asn Arg  Leu Pro Ala 
    1100                 1105                 1110             


Ser Gln  Phe Tyr Glu Phe Ile  Cys Glu Lys Tyr Pro  Glu Ile Lys 
    1115                 1120                 1125             


Gly Glu  Thr Ala Ser Glu Ile  Tyr Leu Asn Phe Ile  Lys Glu Met 
    1130                 1135                 1140             


Ile Pro  Glu Leu Met Lys Leu  
    1145                 1150 


<210>  2257
<211>  1150
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2257

Met Glu Thr Gln Met Leu Gly Ile Ser Tyr Asp His Thr Lys Thr Ala 
1               5                   10                  15      


Asp Lys His Phe Phe Gly Gly Tyr Leu Asn Leu Ala Thr Asn Asn Ile 
            20                  25                  30          


Glu Ser Val Ile Asn Ala Phe Arg Asp Lys Phe Gly Pro Lys Asp Lys 
        35                  40                  45              


Glu Leu Gln Ser Ser Gln Phe Ala Ser Val Cys Phe Lys Asp Asn Asp 
    50                  55                  60                  


Ser Asp Ala Asp Phe Gln Lys Lys Phe Arg Phe Ile Gln Met His Phe 
65                  70                  75                  80  


Pro Val Ile Ser Tyr Leu Gln Lys Glu Gly Asp Arg Ser Ile Leu Arg 
                85                  90                  95      


Asn Asn Phe Ser Leu Leu Leu Asn Val Ile Ser Asp Leu Arg Asn Phe 
            100                 105                 110         


Tyr Thr His Tyr Tyr His Lys Pro Leu Glu Phe Pro Asn Glu Leu Phe 
        115                 120                 125             


Ala Leu Leu Asp Phe Val Phe Gly Lys Val Ala His Glu Val Lys Gln 
    130                 135                 140                 


Tyr Lys Met Lys Asp Asp Asn Thr Arg His Leu Leu Asn Lys Asn Leu 
145                 150                 155                 160 


Ser Glu Glu Leu Glu Ile Arg Tyr Gln Gln Gln Phe Glu Lys Leu Arg 
                165                 170                 175     


Glu Leu Lys Asp Gln Gly Lys Lys Ile Asn Leu Ser Asp Thr Thr Gly 
            180                 185                 190         


Ile Lys Asn Gly Val Leu Asn Asn Ala Phe Ser His Leu Ile Phe Lys 
        195                 200                 205             


Asp Gly Glu Asn Phe Lys Pro Thr Val Ser Tyr Ser Ser Tyr Tyr His 
    210                 215                 220                 


Gly Val Asp Ser Ser Lys Asn Gly Ile Thr Ile Ser Gln Ser Gly Leu 
225                 230                 235                 240 


Leu Phe Leu Leu Ser Met Phe Leu Asn Lys Arg Glu Thr Glu Asn Leu 
                245                 250                 255     


Lys Ser Arg Val Arg Gly Phe Lys Ala Lys Ile Ile Lys Ser Glu Glu 
            260                 265                 270         


Asn Glu Ile Ser Gly Leu Lys Phe Met Ala Thr His Trp Val Phe Ser 
        275                 280                 285             


Tyr Leu Ala Phe Lys Gly Val Lys Gln Arg Leu Asn Phe Asp Phe Gln 
    290                 295                 300                 


Glu Glu Thr Leu Leu Val Gln Ile Ile Asp Glu Leu Ser Lys Val Pro 
305                 310                 315                 320 


Asp Glu Leu Tyr Gln Ser Phe Asp Glu Arg Thr Lys Lys Ser Phe Ile 
                325                 330                 335     


Glu Asp Ile Asn Glu Tyr Met Lys Glu Gly Thr Glu Asp Leu Thr Leu 
            340                 345                 350         


Glu Asp Ser Ile Val Val His Pro Val Ile Arg Lys Arg Tyr Glu Asn 
        355                 360                 365             


Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe Met Glu Phe 
    370                 375                 380                 


Pro Thr Leu Arg Phe Gln Val His Val Gly Asn Tyr Val His Asp Arg 
385                 390                 395                 400 


Arg Val Lys Asn Ile Ala Gly Thr Gly Phe Gln Thr Glu Arg Val Leu 
                405                 410                 415     


Lys Asp Arg Ile Lys Val Phe Gly Lys Leu Thr Glu Ile Asn Asn Leu 
            420                 425                 430         


Lys Ala Asp Tyr Ile Glu Lys Glu Leu Lys Leu Ser Asn Glu Ile Gly 
        435                 440                 445             


Trp Glu Leu Leu Pro Asn Pro Ser Tyr Val Phe Ile Glu Asn Asn Ile 
    450                 455                 460                 


Pro Ile Tyr Leu Ser Met Gly Lys Glu Phe Lys Lys Gly Ile Lys Asp 
465                 470                 475                 480 


Phe Ser Asn Arg Arg Lys Ala Gln Lys Pro Glu Glu Met Lys Asn Arg 
                485                 490                 495     


Asn Gln Glu Lys Ile Arg Lys Asp Gln Ile Thr Gly Ile Ile Gly Asn 
            500                 505                 510         


Lys Asn Glu Leu Asn Pro Glu Lys Pro Val Ala Met Leu Ser Leu Asn 
        515                 520                 525             


Glu Ile Pro Ala Leu Leu Tyr Glu Ile Leu Ile Asn Gly Ala Ser Pro 
    530                 535                 540                 


Ser Glu Ile Glu Asn Thr Ile Gln Asp Lys Leu Asn Ala Ala Phe Glu 
545                 550                 555                 560 


Arg Ile Lys Asp Tyr Asp Pro Lys Ser Pro Val Pro Ala Ser Gln Ile 
                565                 570                 575     


Ser Lys Arg Leu Arg Lys Asn Asn Gly Ile Arg Ser Ile Asp Pro Asp 
            580                 585                 590         


Lys Leu Val His Leu Ile Lys Lys Glu Ile Glu Cys Thr Glu Ala Lys 
        595                 600                 605             


Leu Ser Leu Ile Asp Gln Asn Arg Lys Glu Cys Lys Gln Arg Leu Lys 
    610                 615                 620                 


Gly Lys Leu Ile Arg Glu Arg Val Phe Arg Asn Ser Glu Met Gly Arg 
625                 630                 635                 640 


Glu Ala Thr Trp Ile Ala Glu Asp Ile Lys Arg Phe Met Pro Ala Leu 
                645                 650                 655     


Gln Arg Gln Asn Trp Lys Ala Tyr Gln His Ala Gln Phe Gln Gln Ser 
            660                 665                 670         


Leu Ser Tyr Leu Glu Lys Arg Pro Gly Glu Ala Arg Ser Ile Leu Met 
        675                 680                 685             


Glu Gly Trp Asp Phe Glu Asp Gly Ser Ser Leu Trp Asn Gly Trp Ile 
    690                 695                 700                 


Met Asn Cys Phe Thr Lys Asp Leu Pro Phe Asp Val Phe Tyr Glu Phe 
705                 710                 715                 720 


Tyr Leu Lys Lys Arg Lys Glu Tyr Phe Val Gln Leu Leu Asp Asn Ile 
                725                 730                 735     


Lys His Tyr Ser Thr Asn Val Arg Phe Leu Leu Lys Phe Leu Glu Gln 
            740                 745                 750         


Gln Met Pro Lys Gly Leu Phe Asp Lys Arg His Phe Val Leu Glu Asp 
        755                 760                 765             


Leu Glu Thr Glu Lys Asn Lys Ile Leu Ser Lys Pro Leu Val Phe Pro 
    770                 775                 780                 


Arg Gly Ile Phe Asp Asn Lys Pro Thr Phe Ile Lys Gly Lys Lys Val 
785                 790                 795                 800 


Thr Glu Glu Pro Glu Leu Phe Ala Asn Trp Tyr Gln Tyr Gly Tyr Asp 
                805                 810                 815     


Asn Ser His Lys Phe Gln Arg Phe Tyr Asp Trp Glu Arg Asp Tyr Glu 
            820                 825                 830         


Lys Leu Leu Glu Asp Lys Leu Asn Glu Asp Ala Glu Phe Ala Lys Lys 
        835                 840                 845             


Ser Leu Glu Tyr Ser Arg Ala Asp Gln Leu Ala Leu Leu Lys Leu Lys 
    850                 855                 860                 


Gln Asp Leu Lys Ile Lys Lys Ile Lys Ile Glu Asp Leu Phe Leu Lys 
865                 870                 875                 880 


Leu Met Ala Glu Tyr Leu Phe Lys Lys Ile Phe His Tyr Glu Thr Asn 
                885                 890                 895     


Leu Ser Leu Asp Asp Phe Phe Leu Thr Gln Glu Glu Arg Leu Gln Lys 
            900                 905                 910         


Glu Arg Glu Ala Ala Gln Gln Asn Gln Arg Gln Ala Gly Asp Asp Ser 
        915                 920                 925             


Pro Asn Ile Ile Lys Asp Asp Phe Ile Trp Ser Lys Thr Ile Ala Tyr 
    930                 935                 940                 


Gln Lys Gly Gln Ile Tyr Glu Pro Ser Val Lys Leu Lys Asp Phe Gly 
945                 950                 955                 960 


Lys Phe Lys Ala Tyr Ser Ser Asp Glu Lys Val Lys Ala Leu Leu Ser 
                965                 970                 975     


Tyr Asp Thr Asn Lys Ile Trp Cys Lys Leu Glu Leu Glu Lys Glu Leu 
            980                 985                 990         


Ser Ile Gly Ser Leu Cys Tyr Glu  Ala Ile Arg Arg Glu  Gln Leu Phe 
        995                 1000                 1005             


Asn Glu  Ile Gln Glu Leu Glu  Lys Lys Ile Leu Ser  Asn Trp Asn 
    1010                 1015                 1020             


Trp Asp  Lys Ile Asn His Pro  Tyr Glu Phe Glu Val  Glu Asp Lys 
    1025                 1030                 1035             


Lys Gly  Val Gly His Pro Asn  Phe Lys His Tyr Ile  Val Asn Gly 
    1040                 1045                 1050             


Ile Leu  Arg Lys Asn Asn Ile  Val Phe Asn Glu Gly  Glu Asp Gln 
    1055                 1060                 1065             


Trp Ile  Glu Asp Leu Asn Glu  Asn Gln Phe Lys Thr  Leu Ser Lys 
    1070                 1075                 1080             


Glu Glu  Leu Ala Glu Lys Ser  Glu Ile Ile Gln Ile  Ala Phe Leu 
    1085                 1090                 1095             


Ile Ile  Leu Ile Arg Asn Gln  Phe Ala His Asn Arg  Leu Pro Ala 
    1100                 1105                 1110             


Ser Gln  Phe Tyr Glu Phe Ile  Cys Glu Lys Tyr Pro  Glu Ile Lys 
    1115                 1120                 1125             


Gly Glu  Thr Ala Ser Glu Ile  Tyr Leu Asn Phe Ile  Lys Glu Met 
    1130                 1135                 1140             


Ile Pro  Glu Leu Met Lys Leu  
    1145                 1150 


<210>  2258
<211>  1196
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2258

Met Lys Thr Ser Lys Glu Phe Glu Asn Tyr Asn Ser Arg Asn Ser Phe 
1               5                   10                  15      


Lys Lys Ile Phe Asp Phe Lys Gly Glu Ile Ala Pro Ile Ala Glu Lys 
            20                  25                  30          


Ala Asn Arg Asn Leu Glu Leu Lys Thr Lys Asn Glu Thr Asn Leu Val 
        35                  40                  45              


Gln Arg Val His Tyr Phe Ala Ile Gly His Thr Phe Lys Tyr Ile Asp 
    50                  55                  60                  


Thr Glu Thr Leu Phe Glu Trp Val Val Asp Glu Glu Thr Gln Met Lys 
65                  70                  75                  80  


Gln Pro Thr Lys Phe Leu Ser Leu Gln Ser Phe Asp Asp Ser Phe Cys 
                85                  90                  95      


Asp Glu Leu Gln Lys Ile Thr Val Val Gly Thr Asn Asn Glu Tyr Asn 
            100                 105                 110         


Gly Leu Ile Pro Ala Ile Arg Asn Ile Asn Ser His Tyr Ile His Ser 
        115                 120                 125             


Phe Glu Lys Ile Arg Ile Asp Ser Leu Ser Pro Val Met Val Lys Phe 
    130                 135                 140                 


Leu Lys Glu Ser Phe Glu Leu Ser Val Ile Gln Ile Tyr Ile Lys Glu 
145                 150                 155                 160 


Glu Asn Glu Leu Lys Arg Ser Lys Asn Glu Arg Leu Ala Ser Thr Lys 
                165                 170                 175     


Glu Ile Ile Glu Gln Asn Gly Phe Gly Lys Arg Leu Val Gln Phe Leu 
            180                 185                 190         


Cys Asp Lys Phe Tyr Pro Val Gly Asn Lys Thr Thr Tyr Pro Glu Asp 
        195                 200                 205             


Tyr Leu Glu Tyr Arg Lys Gln Phe Arg Asn Leu Ser Lys Asp Glu Ala 
    210                 215                 220                 


Ile Asp Ser Leu Leu Phe Val Glu Val Glu Thr Ala Phe Asp Trp Leu 
225                 230                 235                 240 


Leu Phe Glu Thr Tyr Pro Ala Phe Asn Ile Ala Val Gly Lys Tyr Leu 
                245                 250                 255     


Ser Phe Tyr Ser Cys Leu Phe Leu Leu Ser Met Phe Leu Tyr Lys Ser 
            260                 265                 270         


Glu Ala Asn Gln Leu Ile Ser Lys Ile Lys Gln Phe Lys Arg Asn Lys 
        275                 280                 285             


Ile Gln Glu Glu Lys Ser Lys Arg Glu Ile Phe Thr Phe Phe Ser Lys 
    290                 295                 300                 


Arg Phe Ser Ser Gln Asp Ile Asp Ser Glu Glu Asn His Leu Val Lys 
305                 310                 315                 320 


Phe Arg Asp Leu Ile Gln Tyr Leu Asn Arg Tyr Pro Val Ala Trp Asn 
                325                 330                 335     


Lys Asp Ile Glu Leu Glu Ser Gln His Pro Val Met Thr Asp Arg Leu 
            340                 345                 350         


Lys Ala Lys Ile Ile Glu Met Glu Ile Asp Ser Ser Phe Pro Ile Tyr 
        355                 360                 365             


Ala Glu Asn Asn Arg Phe His Val Phe Ala Lys Tyr Gln Ile Trp Gly 
    370                 375                 380                 


Lys Lys Tyr Phe Gly Lys Lys Ile Glu Lys Glu Tyr Ile Glu Gln Ser 
385                 390                 395                 400 


Phe Asn Gly Asn Glu Val Glu Glu Phe Ser Tyr Glu Ile Asn Thr Ser 
                405                 410                 415     


Pro Glu Leu Lys Gly Phe Tyr Leu Lys Leu Ala Asp Leu Lys Ser Lys 
            420                 425                 430         


Pro Gly Leu Tyr Glu Lys His Lys Ala Glu Ile Lys Arg Thr Glu Thr 
        435                 440                 445             


Ser Ile Lys Glu Leu Ile Glu Gln Asn Val Pro Asn Pro Ile Thr Glu 
    450                 455                 460                 


Lys Leu Lys Thr Arg Ile Glu Lys Asn Leu Leu Phe Val Ser Tyr Gly 
465                 470                 475                 480 


Arg Asn Gln Asp Arg Phe Met Asp Phe Ala Thr Arg Tyr Leu Ala Glu 
                485                 490                 495     


Thr Asn Tyr Phe Gly Asn Asp Ala Arg Phe Lys Met Tyr Gln Phe Tyr 
            500                 505                 510         


Thr Thr Thr Glu Gln Asn Lys Glu Tyr Glu Asn Leu Lys Glu Val Lys 
        515                 520                 525             


Ser Lys Lys Glu Ile Asp Arg Leu Lys Phe His His Gly Arg Pro Ile 
    530                 535                 540                 


His Phe Ser Thr Tyr Ser Asn His His Lys Arg Tyr Glu Ser Trp Asp 
545                 550                 555                 560 


Thr Pro Phe Val Phe Glu Asn Asn Ala Ile Gln Val Lys Met Thr Leu 
                565                 570                 575     


Asp His Gly Ile Glu Lys Thr Val Ser Ile Gln Arg Ser Leu Met Val 
            580                 585                 590         


Tyr Leu Leu Glu Asp Ala Leu Phe Lys Ala Asp Lys Ser Met Val Asp 
        595                 600                 605             


Ser Ala Gly Lys His Leu Ile Ser Glu Tyr Phe Thr His Gln Gln Gln 
    610                 615                 620                 


Asp Phe Asn Tyr Ser Arg Leu Val Leu Glu Gln Asn Glu Ser Ile Asn 
625                 630                 635                 640 


Thr Glu Gln Lys Asn Lys Phe Lys Lys Ile Leu Pro Lys Arg Leu Leu 
                645                 650                 655     


Asn His Tyr Leu Pro Ala Ile Gln Asn Asn Thr Pro Ala Phe Ser Thr 
            660                 665                 670         


Leu Gln Leu Ile Leu Glu Lys Ala Lys Leu Ala Glu Glu Arg Tyr Lys 
        675                 680                 685             


Lys Leu Thr Glu Lys Val Lys Thr Glu Gly Asn Tyr Asp Asp Phe Ile 
    690                 695                 700                 


Lys Arg Asn Lys Gly Lys Gln Phe Lys Leu Gln Phe Ile Arg Lys Ala 
705                 710                 715                 720 


Trp His Leu Met Tyr Phe Lys Glu Ser Tyr Lys Gln Gln Ala Ser Phe 
                725                 730                 735     


Ser Gly His His Lys Arg Phe His Ile Glu Arg Asp Glu Phe Asn Asp 
            740                 745                 750         


Phe Ser Arg Phe Met Phe Ala Phe Asp Glu Val Pro Ala Tyr Lys Asp 
        755                 760                 765             


Tyr Leu Lys Gln Leu Leu Asp Lys Lys Gly Phe Phe Glu Asn Gln Gln 
    770                 775                 780                 


Phe Lys Ala Leu Phe Glu Asn Gly Thr Ser Leu Asp Asn Leu Tyr Val 
785                 790                 795                 800 


Lys Thr Lys Gln Ala Tyr Glu Lys Trp Leu Ile Gly Gln Asn Asn Arg 
                805                 810                 815     


Glu Leu Glu Ala Thr Lys Tyr Thr Leu Gln Ser Tyr Glu Gln Phe Phe 
            820                 825                 830         


Ala Asp Asp Met Phe Tyr Ile Asn Gln Ser His Phe Ile Ser Phe Leu 
        835                 840                 845             


Glu Ser Lys Ser Leu Leu Ser Arg Asp Glu Gln Gly Gln Met Arg Phe 
    850                 855                 860                 


Asn Ala Leu Ala Asn Cys Ala Phe Leu Val Ser Glu Phe Tyr Tyr Thr 
865                 870                 875                 880 


Asp Lys Leu Asp Lys Thr Glu Tyr Lys Thr Asn Arg Lys Leu Phe Asn 
                885                 890                 895     


Gln Leu Arg Ser Val Arg Leu Glu Asp Ala Leu Leu Tyr Glu Met Ala 
            900                 905                 910         


Met Cys Tyr Leu Lys Ile Asp Gln Gln Val Val Gln Lys Ala Lys Ala 
        915                 920                 925             


His Val Ile Glu Ile Leu Thr Gln Asn Val Gln Phe Asp Ile Cys Asn 
    930                 935                 940                 


Ser Gln Asp Lys Leu Val Tyr His Leu Val Ile Pro Phe Asn Lys Ile 
945                 950                 955                 960 


Asp Ala Tyr Val Glu Leu Leu Asn Arg Lys Glu Thr Asp Glu Thr Ile 
                965                 970                 975     


Ser Ser Gly Ser Ser Phe Ile Thr Asn Val Asp Lys Tyr Ile Glu Met 
            980                 985                 990         


Ile Trp Asn Glu Ile Pro Trp Lys  Glu Lys Asn Glu Asn  Ala Lys Lys 
        995                 1000                 1005             


Ile Thr  His Ala Ala Met Tyr  Pro Ile Gly Glu Lys  Tyr Ser Arg 
    1010                 1015                 1020             


Gln Lys  Thr Ile Thr Tyr Asp  Asp Leu Gln Lys Ile  Tyr Gln His 
    1025                 1030                 1035             


Leu Leu  Ser Ser Ser Asn Lys  Leu Thr Asn Val Ser  Met Gln Ile 
    1040                 1045                 1050             


Glu Arg  Tyr Tyr Leu Cys Lys  Pro Asp Gly Gln Gly  His Val Val 
    1055                 1060                 1065             


Phe Asn  Gly Glu Thr Asp Arg  Lys Thr Gly Cys Tyr  Leu Ile Arg 
    1070                 1075                 1080             


Phe Glu  Lys Thr Gly Val Pro  Lys Thr Tyr Phe Gly  Val Gly Glu 
    1085                 1090                 1095             


Leu Asn  Ile Arg Asn Lys Ala  Phe His Phe Leu Ile  Thr Pro Ser 
    1100                 1105                 1110             


Lys Ser  Tyr Glu Lys Trp Leu  Met Asp Val Glu Arg  Glu Phe Ile 
    1115                 1120                 1125             


Leu Lys  Glu Val Lys Pro Asn  Asn Pro Lys Ala Tyr  Thr Asp Leu 
    1130                 1135                 1140             


Asn Arg  Ser Val Lys Leu Val  Cys Asp Ile Leu Leu  Asn Thr Leu 
    1145                 1150                 1155             


His Asn  Asn Tyr Phe Lys Leu  Thr Asp Ser Asp Lys  Gly Ile Pro 
    1160                 1165                 1170             


Lys Glu  Glu Gln Gly Lys Gln  Lys Gln Lys Asn Ala  Gln Ile Thr 
    1175                 1180                 1185             


Tyr Phe  Thr Lys His Ile Leu  Tyr 
    1190                 1195     


<210>  2259
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2259

Leu Gln Lys Gln Asp Lys Leu Phe Val Asp Arg Lys Lys Asn Ala Ile 
1               5                   10                  15      


Phe Ala Phe Pro Lys Tyr Ile Thr Ile Met Glu Asn Lys Glu Lys Thr 
            20                  25                  30          


Glu Pro Ile Tyr Tyr Glu Leu Thr Asp Lys His Phe Trp Ala Ala Phe 
        35                  40                  45              


Leu Asn Leu Ala Arg His Asn Val Tyr Thr Thr Val Asn His Ile Asn 
    50                  55                  60                  


Lys Leu Leu Glu Ile Ala Glu Leu Lys Asn Asp Glu Asp Val Leu Asn 
65                  70                  75                  80  


Ile Lys Asp Ser Trp Asn Lys Gln Ala Glu Lys Leu Asp Lys Lys Val 
                85                  90                  95      


Arg Leu Arg Asn Leu Leu Met Arg His Phe Pro Phe Leu Glu Ala Ala 
            100                 105                 110         


Ala Tyr Glu Lys Thr Thr Ser Lys Asp Ser Asn Ser Lys Glu Gln Lys 
        115                 120                 125             


Glu Lys Glu Gln Ala Glu Ala Leu Ser Leu Asp Asn Leu Lys Asn Val 
    130                 135                 140                 


Leu Phe Ile Phe Leu Glu Lys Leu Gln Ser Leu Arg Asn Tyr Tyr Ser 
145                 150                 155                 160 


His Tyr Lys Tyr Ser Glu Glu Ala Gln Lys Pro Thr Phe Glu Asn Asp 
                165                 170                 175     


Leu Leu Lys Asn Met Tyr Lys Ile Phe Asp Thr Asn Val Arg Leu Val 
            180                 185                 190         


Lys Arg Asp Tyr Met His His Glu Asn Val Asp Met Gln Arg Asp Phe 
        195                 200                 205             


Ser His Leu Asn Arg Lys Lys Gln Glu Gly Gln Thr Arg Lys Ile Ile 
    210                 215                 220                 


Ala Asn Pro Asn Phe Arg Tyr His Phe Ala Asp Glu Lys Gly Asp Met 
225                 230                 235                 240 


Thr Ile Ala Gly Leu Leu Phe Phe Ile Ser Leu Phe Leu Asp Lys Lys 
                245                 250                 255     


Asp Ala Ile Trp Met Gln Lys Lys Leu Lys Gly Phe Lys Asp Gly Arg 
            260                 265                 270         


Asn Leu Arg Glu Gln Met Thr Asn Glu Val Phe Cys Arg Ser Arg Ile 
        275                 280                 285             


Ser Leu Pro Lys Leu Lys Leu Glu Asn Val Gln Thr Lys Asp Trp Met 
    290                 295                 300                 


Gln Leu Asp Met Leu Asn Glu Leu Val Arg Cys Pro Lys Ser Leu Tyr 
305                 310                 315                 320 


Glu Arg Leu Arg Glu Lys Asp Arg Glu Ser Phe Lys Val Pro Phe Asp 
                325                 330                 335     


Ile Phe Ser Asp Asp Tyr Asp Ala Glu Glu Glu Pro Phe Lys Asn Thr 
            340                 345                 350         


Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe 
        355                 360                 365             


Asp Leu Asn Glu Ile Phe Glu Gln Leu Arg Phe Gln Ile Asp Leu Gly 
    370                 375                 380                 


Thr Tyr His Phe Ser Ile Tyr Asn Lys Arg Ile Gly Asp Glu Asp Glu 
385                 390                 395                 400 


Val Arg His Leu Thr His His Leu Tyr Gly Phe Ala Arg Ile Gln Asp 
                405                 410                 415     


Phe Ala Pro Gln Asn Gln Pro Glu Glu Trp Arg Lys Leu Val Lys Asp 
            420                 425                 430         


Leu Asp His Phe Glu Thr Ser Gln Glu Pro Tyr Ile Ser Lys Thr Ala 
        435                 440                 445             


Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Lys Phe Cys Ser 
    450                 455                 460                 


Thr His Asn Asn Leu Phe Pro Ser Leu Lys Arg Glu Lys Thr Cys Asn 
465                 470                 475                 480 


Gly Arg Ser Lys Phe Asn Leu Gly Thr Gln Phe Thr Ala Glu Ala Phe 
                485                 490                 495     


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu 
            500                 505                 510         


Thr Lys Asp Tyr Ser Arg Lys Glu Ser Ala Asp Lys Val Glu Gly Ile 
        515                 520                 525             


Ile Arg Lys Glu Ile Ser Asn Ile Tyr Ala Ile Tyr Asp Ala Phe Ala 
    530                 535                 540                 


Asn Gly Glu Ile Asn Ser Ile Ala Asp Leu Thr Cys Arg Leu Gln Lys 
545                 550                 555                 560 


Thr Asn Ile Leu Gln Gly His Leu Pro Lys Gln Met Ile Ser Ile Leu 
                565                 570                 575     


Glu Gly Arg Gln Lys Asp Met Glu Lys Glu Ala Glu Arg Lys Ile Gly 
            580                 585                 590         


Glu Met Ile Asp Asp Thr Gln Arg Arg Leu Asp Leu Leu Cys Lys Gln 
        595                 600                 605             


Thr Asn Gln Lys Ile Arg Ile Gly Lys Arg Asn Ala Gly Leu Leu Lys 
    610                 615                 620                 


Ser Gly Lys Ile Ala Asp Trp Leu Val Asn Asp Met Met Arg Phe Gln 
625                 630                 635                 640 


Pro Val Gln Lys Asp Gln Asn Asn Ile Pro Ile Asn Asn Ser Lys Ala 
                645                 650                 655     


Asn Ser Thr Glu Tyr Arg Met Leu Gln Arg Ala Leu Ala Leu Phe Gly 
            660                 665                 670         


Ser Glu Asn Phe Arg Leu Lys Ala Tyr Phe Asn Gln Met Asn Leu Val 
        675                 680                 685             


Gly Asn Asp Asn Pro His Pro Phe Leu Ala Glu Thr Gln Trp Glu His 
    690                 695                 700                 


Gln Thr Asn Ile Leu Ser Phe Tyr Arg Asn Tyr Leu Glu Ala Arg Lys 
705                 710                 715                 720 


Lys Tyr Leu Lys Gly Leu Lys Pro Gln Asn Trp Lys Gln Tyr Gln His 
                725                 730                 735     


Phe Leu Ile Leu Lys Val Gln Lys Thr Asn Arg Asn Thr Leu Val Thr 
            740                 745                 750         


Gly Trp Lys Asn Ser Phe Asn Leu Pro Arg Gly Ile Phe Thr Gln Pro 
        755                 760                 765             


Ile Arg Glu Trp Phe Glu Lys His Asn Asn Ser Lys Arg Ile Tyr Asp 
    770                 775                 780                 


Gln Ile Leu Ser Phe Gly Arg Val Gly Phe Val Ala Lys Ala Ile Pro 
785                 790                 795                 800 


Leu Tyr Phe Ala Glu Glu Cys Lys Asp Cys Val Gln Pro Phe Tyr Asp 
                805                 810                 815     


Tyr Pro Phe Asn Val Gly Asn Lys Leu Lys Pro Lys Lys Gly Gln Phe 
            820                 825                 830         


Leu Asp Lys Lys Asp Arg Val Glu Leu Trp Gln Lys Asn Lys Glu Leu 
        835                 840                 845             


Phe Lys Asn Tyr Pro Pro Glu Lys Arg Lys Thr Asp Leu Ala Tyr Leu 
    850                 855                 860                 


Asp Phe Leu Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys 
865                 870                 875                 880 


Asn Gln Asp Ile Val Thr Trp Leu Met Phe Lys Glu Leu Phe Lys Thr 
                885                 890                 895     


Thr Thr Val Glu Gly Leu Lys Ile Gly Glu Ile His Leu Arg Asp Ile 
            900                 905                 910         


Asp Thr Asn Thr Ala Asn Glu Glu Ser Asn Asn Ile Leu Asn Arg Ile 
        915                 920                 925             


Met Pro Met Lys Leu Pro Val Lys Thr Tyr Glu Thr Asp Asn Lys Gly 
    930                 935                 940                 


Asn Ile Leu Lys Glu Arg Pro Leu Ala Thr Phe Tyr Ile Glu Glu Thr 
945                 950                 955                 960 


Glu Thr Lys Val Leu Lys Gln Gly Asn Phe Lys Val Leu Ala Lys Asp 
                965                 970                 975     


Arg Arg Leu Asn Gly Leu Leu Ser Phe Ala Glu Thr Thr Asp Ile Asp 
            980                 985                 990         


Leu Glu Lys Asn Pro Ile Thr Lys  Leu Ser Val Asp His  Glu Leu Ile 
        995                 1000                 1005             


Lys Tyr  Gln Thr Thr Arg Ile  Ser Ile Phe Glu Met  Thr Leu Gly 
    1010                 1015                 1020             


Leu Glu  Lys Lys Leu Ile Asp  Lys Tyr Ser Thr Leu  Pro Thr Asp 
    1025                 1030                 1035             


Ser Phe  Arg Asn Met Leu Glu  Arg Trp Leu Gln Cys  Lys Ala Asn 
    1040                 1045                 1050             


Arg Pro  Glu Leu Lys Asn Tyr  Val Asn Ser Leu Ile  Ala Val Arg 
    1055                 1060                 1065             


Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met Tyr Asp  Ala Thr Leu 
    1070                 1075                 1080             


Phe Ala  Glu Val Lys Lys Phe  Thr Leu Phe Pro Ser  Val Asp Thr 
    1085                 1090                 1095             


Lys Lys  Ile Glu Leu Asn Ile  Ala Pro Gln Leu Leu  Glu Ile Val 
    1100                 1105                 1110             


Gly Lys  Ala Ile Lys Glu Ile  Glu Lys Ser Glu Asn  Lys Asn 
    1115                 1120                 1125         


<210>  2260
<211>  1088
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2260

Met Lys Ile Pro Asp Leu Ile Asn Asn Tyr Lys Glu Gln Phe Gly Thr 
1               5                   10                  15      


Tyr Ala Val Met Ala Leu Met Asn Ala Gln Thr Val Leu Asp His Ile 
            20                  25                  30          


Gln Lys Leu Ala Cys Ile Gly Asn Ser Glu Ser Tyr Lys Glu Asp Leu 
        35                  40                  45              


Trp Lys His Pro Val Met Leu His Ile Lys Asn Ala Ala Tyr Glu Thr 
    50                  55                  60                  


Asp Asn Asn Pro Glu Thr Thr Leu Phe Val Met Glu Lys Leu Gln Phe 
65                  70                  75                  80  


Tyr Phe Pro Phe Leu Lys Ile Met Ala Glu Arg Gln Arg Glu Tyr Ser 
                85                  90                  95      


Asn Lys Lys Tyr Asn Glu Asn Arg Leu Ala Val Asn Ser Arg Asp Leu 
            100                 105                 110         


Phe Phe Val Leu Asp Lys Val Phe Arg Val Leu Lys Asn Tyr Arg Asn 
        115                 120                 125             


Thr Thr Ala His Phe Met Thr Lys Ser Leu Ser Glu Asn Glu Glu Tyr 
    130                 135                 140                 


Leu Phe Leu Lys Asn Glu Gln Pro Leu Ala Asn Met Val Asn Glu Tyr 
145                 150                 155                 160 


Tyr Thr Val Ala Leu Arg Asp Met Lys Asp Arg Tyr Ser Tyr Ser Thr 
                165                 170                 175     


Glu Asp Leu Ala Phe Ile Gln Asp Asn Arg Tyr Lys Gln Thr Arg Gly 
            180                 185                 190         


Asp Asp Gly Lys Arg Lys Ala Thr Val Asn Leu Asp Phe Phe Leu Ser 
        195                 200                 205             


Leu Gln Ser His Asn Gly Asp Pro Ala Lys Lys Leu His Leu Ser Gly 
    210                 215                 220                 


Val Gly Val Ala Leu Leu Ile Cys Leu Phe Leu Glu Lys Gln Tyr Val 
225                 230                 235                 240 


Asn Leu Phe Ile Ser Lys Leu Ser Ile Phe Ser Thr Tyr Lys Pro Asn 
                245                 250                 255     


Ser Glu Gln His Arg Ile Ile Cys Arg Ser Met Gly Ile His Ser Ile 
            260                 265                 270         


Lys Leu Pro Lys Asp Arg Ile His Ser Leu Lys Asp Gly Met Ser Val 
        275                 280                 285             


Ala Met Asp Met Leu Asn Glu Thr Lys Arg Cys Pro Lys Glu Leu Phe 
    290                 295                 300                 


Asp Thr Leu Ser Ala Asp Lys Gln Ala Arg Phe Arg Thr Ile Ser Asp 
305                 310                 315                 320 


Asp His Asn Glu Val Leu Leu Met Arg Ser Ser Asp Arg Phe Ala Gln 
                325                 330                 335     


Leu Leu Leu Gln Tyr Ile Asp Tyr Asn Lys Leu Phe Lys Gly Ile Arg 
            340                 345                 350         


Phe His Val Asn Met Gly Lys Leu Arg Tyr Leu Phe Asn Ala Ala Lys 
        355                 360                 365             


Asn Cys Ile Asp Gly Gln Thr Arg Val Arg Val Ile Glu His Gln Leu 
    370                 375                 380                 


Asn Gly Tyr Gly Arg Ile Asp Glu Ile Glu Ala Glu Arg Lys Ser Glu 
385                 390                 395                 400 


Asp Gly Lys Phe Ala Asn Ser Gly Ile Ser Ile Arg Asp Phe Glu Asn 
                405                 410                 415     


Val Arg Arg Asp Asp Gly Asn Pro Glu Asn Tyr Pro Tyr Val Val Asp 
            420                 425                 430         


Thr Tyr Ser His Tyr Ile Leu Glu Asn Asn Lys Val Glu Met Gln Phe 
        435                 440                 445             


Thr Asp Ser Cys Ile Leu Pro Phe Ile Glu Glu Tyr Gly Gly Lys Trp 
    450                 455                 460                 


Tyr Val Ala Lys Asp Val Pro Ala Cys Arg Ile Ser Thr Leu Glu Leu 
465                 470                 475                 480 


Pro Ala Leu Ala Phe His Met Leu Leu Leu Gly Ser Lys Lys Thr Glu 
                485                 490                 495     


Glu Arg Ile Lys Glu Val Tyr Gly Lys Tyr Met Lys Leu Phe Glu Ala 
            500                 505                 510         


Met Ser Asn Asp Ala Val Thr Lys Glu Asn Ile Glu Ser Phe Gly Ile 
        515                 520                 525             


Ala Leu Trp Asn Leu Pro Gln Lys Ala Ile Asp Ala Ile Asn Gly Cys 
    530                 535                 540                 


Ala His Ala Lys Asn Val Asn Ala Phe Ile Lys Asn Thr Val Glu Glu 
545                 550                 555                 560 


Met Leu Ala Asp Thr Glu Lys Arg Leu Glu Arg Leu Lys Glu Asp Arg 
                565                 570                 575     


Lys Gly Ile Ser Ser His Asp Asn Lys Met Gly Lys Pro Asn Phe Arg 
            580                 585                 590         


Gln Ile Ser Thr Gly Arg Leu Ala Asp Phe Leu Ala Lys Asp Ile Val 
        595                 600                 605             


Lys Leu Gln Pro Ala Thr Thr Glu Asp Gly Ser Asp Lys Met Thr Gly 
    610                 615                 620                 


Leu Asn Tyr Arg Val Met Gln Ala Ala Ile Ala Thr Tyr Asn Ser Asn 
625                 630                 635                 640 


Gly Asn Pro Glu Ala Glu Gln Gln Phe Arg Gly Met Phe Glu Lys Ala 
                645                 650                 655     


Arg Leu Ile Gly Lys Ser Pro Asn Ala His Pro Phe Leu Tyr Lys Val 
            660                 665                 670         


Phe Ala Ser Ala Leu Pro Lys Asn Thr Ile Glu Phe Tyr Asp Lys Tyr 
        675                 680                 685             


Leu Arg Glu Arg Lys Arg Tyr Leu Ser Asn Leu Thr Lys Asp Ile Glu 
    690                 695                 700                 


Ser Gly Lys Thr Ala Ser Val Pro Phe Val Asn Arg Asn Gln Asn Lys 
705                 710                 715                 720 


Trp Lys Lys Pro Asn Gln Glu Tyr Leu Gly Gln Thr Tyr Gly Asn Ser 
                725                 730                 735     


Gln Asn Leu Ala Ile Glu Leu Pro Arg Gln Met Phe Asp Ala Asp Ile 
            740                 745                 750         


Lys Ala Phe Leu Lys Gly Leu Pro Glu Met Lys Asp Val Asp Phe Asp 
        755                 760                 765             


Asn Ala Asn Val Thr Phe Leu Ile Gly Glu Tyr Met Lys Arg Val Leu 
    770                 775                 780                 


Ala Asp Asp Phe Gln Asn Phe Tyr Ala Trp Lys Arg Asn Tyr Arg Tyr 
785                 790                 795                 800 


Met Asp Met Leu Met Gly Glu Thr Asp Ser Lys Asp Gly Leu Arg His 
                805                 810                 815     


Met Phe Thr Ser Val Glu Glu Arg Glu Lys Leu Trp Arg Glu Arg Glu 
            820                 825                 830         


Gly Arg Thr Ser Ser Tyr Arg Lys Trp Ala Ala Arg Lys Asn Gln Gly 
        835                 840                 845             


Cys Gly Tyr Ser Lys Arg Leu Pro Asp Asn Val Leu Asp Glu Ile Leu 
    850                 855                 860                 


Ala Lys Arg Leu Ser Gly Ser Arg Asn Asp Tyr Gln Lys Cys Glu Lys 
865                 870                 875                 880 


Ala Ile Arg Arg Gln Lys Val Gln Asp Ala Met Leu Phe Met Leu Ala 
                885                 890                 895     


Lys Lys Ala Phe Thr Gln His Ala Asp Phe Glu Gly Lys Asp Phe Lys 
            900                 905                 910         


Leu Lys Asn Ile Met Pro Asp Ala Asp Lys Gly Ile Leu Ser Glu Thr 
        915                 920                 925             


Met Pro Met Thr Phe Thr Phe Glu Lys Gly Gly Lys Gln Tyr Thr Ile 
    930                 935                 940                 


Glu Ser Gly Gly Met Lys Leu Lys Asn Tyr Gly Asp Phe His Ala Leu 
945                 950                 955                 960 


Ala Asn Asp Arg Arg Ile Gly Cys Leu Met Lys Leu Ile Gly Thr Asn 
                965                 970                 975     


Thr Ala Gln Lys Glu Asp Leu Ile Ser Glu Phe Asn Lys Tyr Asp Gln 
            980                 985                 990         


Cys Arg Pro Gln Val Val Lys Leu  Val Leu Asp Leu Glu  Lys Trp Ala 
        995                 1000                 1005             


Phe Ala  Lys Tyr Pro Glu Leu  Gly Ala Ser Glu Glu  Met Ser Tyr 
    1010                 1015                 1020             


Val Ser  Phe Asp Lys Ile Leu  Asn Lys Leu Thr Gln  His Arg Asn 
    1025                 1030                 1035             


Leu Gly  Asn Arg Gln Ser Asn  Ile Leu Arg Lys Ile  Arg Asn Ala 
    1040                 1045                 1050             


Phe Asp  His Asn Ser Tyr Pro  Glu Ser Gly Ile Val  Glu Ile Thr 
    1055                 1060                 1065             


Thr Leu  Pro Glu Ile Ala Gln  Asn Met Lys Asp Met  Phe Gly Arg 
    1070                 1075                 1080             


Tyr Ala  Ile Val Lys 
    1085             


<210>  2261
<211>  1229
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2261

Met Glu Asn Asn Pro Ser Asn Arg Phe Ser Lys Pro Thr Val Pro Pro 
1               5                   10                  15      


Lys Thr Arg Arg Ser Glu Gly Cys Glu Lys Pro Asp Ser His Ser Ala 
            20                  25                  30          


Glu Leu Arg Pro Val Phe Ala Ala Tyr Leu Asn Met Ala Gln Met Asn 
        35                  40                  45              


Leu Phe Asn Thr Leu Lys Ala Ile Glu Gly Lys Leu Gly Ile Val Thr 
    50                  55                  60                  


Gln Asn Ala Lys Glu Asp Cys Met Glu Gly Met Lys Ile Val Asp Phe 
65                  70                  75                  80  


Asp Lys Asn Ile Lys Glu Val Glu Val Arg Val Lys Ala Phe Lys Glu 
                85                  90                  95      


Leu Leu Lys Arg Ile Pro Val Leu Gln Ser Leu Ser Gly Tyr Gln Ile 
            100                 105                 110         


Lys Asp Asp Val Lys Thr Val Ser Phe Glu Asp Val Ala Glu Leu Leu 
        115                 120                 125             


Arg Ala Ile Val Lys Ile Val His Tyr Tyr Arg Asn Glu Tyr Ser His 
    130                 135                 140                 


Thr His His Tyr Tyr Thr Asp Ala Glu Lys Ala Glu Glu Ala Asp Phe 
145                 150                 155                 160 


Glu Lys Arg Ile Met Gln Pro Leu Asp Leu Ala Phe Met Ser Ala Lys 
                165                 170                 175     


Arg Asn Met Ala Lys Val His Gly Tyr Gly Lys Lys Glu Leu Asp Phe 
            180                 185                 190         


Ile Asp Gly Asn Glu Arg Gln Glu Val Thr Gly Lys Gly Arg Asp Lys 
        195                 200                 205             


Lys Val Lys Tyr Tyr Thr Asp Tyr Tyr Phe Arg Leu Gly Asn Asp Asp 
    210                 215                 220                 


Phe Thr Arg Leu Ser Asp Val Gly Ile Ala Phe Ile Val Cys Lys Leu 
225                 230                 235                 240 


Leu Asn Lys Lys Tyr Ala Ile Gln Phe Leu Gln Gln Ser Lys Ile Met 
                245                 250                 255     


Thr Pro Arg Ser Gln Gly Gly Leu Ser Pro Phe Ser Gln Glu Glu Asn 
            260                 265                 270         


Glu Val Met Ala Asn Ile Phe Cys Ala Glu Arg Ile Arg Leu Pro Lys 
        275                 280                 285             


Gly Arg Met Glu Val Glu Ser Leu Asp Arg Lys Ala Ala Leu Gly Leu 
    290                 295                 300                 


Asp Met Leu Asn Glu Leu Gln Lys Cys Pro Lys Glu Leu Phe Asp Thr 
305                 310                 315                 320 


Phe Cys Gln Asp Asp Lys Glu Leu Phe Lys Val Val Gln Asp Glu Glu 
                325                 330                 335     


Glu Gln Gln Ser Asp Leu Glu Asp Gly Ala Leu Met Arg Arg Asn Asp 
            340                 345                 350         


Asp Arg Phe Pro Val Leu Ala Leu Arg Tyr Ile Asp Glu Gln Lys Val 
        355                 360                 365             


Leu Asn Gly Met Ala Phe Gln Val Ser Leu Gly Asn Tyr Arg Tyr Gln 
    370                 375                 380                 


Phe Tyr Asn Lys Thr Thr Ile Asp Pro Ser Asn Pro Asn Arg Val Arg 
385                 390                 395                 400 


Ile Leu Gln Lys Glu Ile Asn Gly Phe Gly Pro Met His Leu Val Glu 
                405                 410                 415     


Ser Lys Phe Lys Gly Lys Tyr Gly Lys Asp Gly Leu Asn Leu Ile Arg 
            420                 425                 430         


Glu Ser Gln Ser Glu Ala Pro Ala Asp Thr Ala Ala Thr Lys Pro Tyr 
        435                 440                 445             


Leu Thr Asp Lys Arg Ala Ser Tyr Val Ile His Asn Asn Arg Val Cys 
    450                 455                 460                 


Ile Met Leu Lys Glu Lys Gly Ser Pro Leu Asp Lys Asp Cys Cys Tyr 
465                 470                 475                 480 


Leu Pro Asp Leu Pro Val Pro Lys Glu Glu Asn Gly Thr Gln Lys Val 
                485                 490                 495     


Asn Arg Pro Gly Asp Glu Lys Glu Lys Asp Trp Pro His Thr Cys Trp 
            500                 505                 510         


Leu Ser Ile Tyr Asp Leu Pro Ala Leu Val Phe Leu His Leu Leu Gly 
        515                 520                 525             


Gly Asn Pro Gly Gln Val Ile Arg Asp Tyr Val Gly Lys Ile Arg Ser 
    530                 535                 540                 


Leu Leu Asn Asp Ile Ala Glu Glu Lys Cys Val Pro Pro Cys Cys Asp 
545                 550                 555                 560 


Glu Pro Ser Pro Thr Asn Gly Pro Gln Gln Lys Lys Thr Ile Thr Lys 
                565                 570                 575     


Pro Lys Asp Glu Val Ser Ile Trp Leu Lys Glu Gln Tyr Glu Leu Pro 
            580                 585                 590         


Leu Ser Ser Val Pro Glu Lys Ile Val Asp Tyr Leu Ala Gly Val Ser 
        595                 600                 605             


Gly Gly Ser Met Glu Glu Glu Arg Leu Lys Ala Glu Asp Gly Phe Ser 
    610                 615                 620                 


Lys Trp Ala Lys Ser Ala Val Glu Lys Glu Ile Gly Asp Thr Glu Leu 
625                 630                 635                 640 


Arg Gln Lys Arg Phe Gln Asn Asp Lys Lys Arg Val Gly Ser Lys Ala 
                645                 650                 655     


Asn Arg Ile Gly Lys Lys Ser Tyr Val Glu Ile Arg Pro Gly Arg Leu 
            660                 665                 670         


Ala Asp Phe Leu Ala Lys Asp Ile Met Lys Met Gln Pro Ala Asp Ala 
        675                 680                 685             


Glu Lys Asn His Cys Gly Lys Leu Thr Gly Gln Asn Tyr Gln Ile Met 
    690                 695                 700                 


Gln Ala Ala Ile Ala Thr Phe Lys Gly Asp Gly Arg Glu Cys Arg Leu 
705                 710                 715                 720 


Thr Gly Leu Gly Glu Leu Phe Val Lys Ala Gly Leu Val Gly Lys Asp 
                725                 730                 735     


Asn Arg Gln Lys His Pro Phe Leu Asp Lys Val Leu Thr Asn Glu Ile 
            740                 745                 750         


Thr Asp Thr Leu Asp Phe Tyr Glu Lys Tyr Leu Glu Glu Lys Lys Tyr 
        755                 760                 765             


Tyr Leu Glu Gln Leu Leu Cys Ser Glu Lys Tyr Ser Glu Ala Tyr Phe 
    770                 775                 780                 


Leu His Gly Gly Leu Asn Asp Tyr Lys Pro Lys Asp Arg Asp Tyr Ile 
785                 790                 795                 800 


Lys Leu Leu Ala Gly Arg Tyr Lys Asp Thr Phe Gln Leu Pro Asp Gly 
                805                 810                 815     


Leu Phe Ala Asp Ala Ile Ser Glu Cys Leu Lys Lys Glu Asp Asn Val 
            820                 825                 830         


Glu Ile Arg Asn Ala Ala Glu Gly Glu Asn Arg Asn Asn Ala Ala Tyr 
        835                 840                 845             


Leu Leu Arg Val Tyr Phe Thr Asn Lys Tyr Asp Asp Asp Ser Gln Pro 
    850                 855                 860                 


Phe Tyr Phe Gln Thr Asp Gly Arg Phe Lys Arg His Tyr Lys Val Phe 
865                 870                 875                 880 


Asp Thr Ile Glu Gly Lys Lys Asp Ala Thr Tyr Arg Thr Val Glu Glu 
                885                 890                 895     


Ile Arg Ala Met Leu Arg Lys Gly Ala Ala Asp Lys Ala Pro Val Arg 
            900                 905                 910         


Arg Asp Ile Ala Glu His Leu Asn Thr Leu Gln Met Pro Gly Glu Pro 
        915                 920                 925             


Gln Trp Ile Asn Gly Lys Lys Lys Pro Ser Trp Arg Glu Ala Thr Pro 
    930                 935                 940                 


Asp Glu Lys Glu Ser Glu Ala Lys Lys Cys Gln Met Gln Leu Arg Tyr 
945                 950                 955                 960 


Cys Gln Gln Asn Glu Arg Ala Ile Arg Arg Tyr Lys Ala Glu Asp Met 
                965                 970                 975     


Leu Met Phe Met Met Ala Lys Arg Leu Leu Leu Glu Ser Asp Asn Val 
            980                 985                 990         


Leu Lys Lys Gly Asn Leu Asn Gly  Leu Glu Ala Phe Lys  Leu Arg Asp 
        995                 1000                 1005             


Ile Lys  Pro Ile Gly Cys Lys  Asn Gly Pro Gln Asp  Asn Ile Leu 
    1010                 1015                 1020             


Asn Gln  Gln Ile Asp Phe Ser  Ala Ala Ile Asp Leu  Phe Val Glu 
    1025                 1030                 1035             


Glu Val  Val His Tyr Thr Asp  Lys Lys Gly Glu Glu  Gly Thr Ser 
    1040                 1045                 1050             


Phe Val  Ser Val Asn Lys Gly  Lys Lys Val Ile His  Gln Ser Gly 
    1055                 1060                 1065             


Leu Lys  Ile Lys Asn Ile Gly  Asp Phe Tyr Arg Phe  Ile Phe Asp 
    1070                 1075                 1080             


Ser Arg  Leu Gly Ser Leu Leu  Ser Gln Ile Glu Gly  Asp Thr Phe 
    1085                 1090                 1095             


Glu Arg  Glu Met Val Glu Lys  Glu Leu Asp Thr Tyr  Asp Asn Arg 
    1100                 1105                 1110             


Arg Lys  Asp Gly Phe Lys Thr  Ala His Glu Ile Glu  Arg Val Ile 
    1115                 1120                 1125             


Ile Gly  Lys Asn Lys Glu Gln  Ile Glu Thr Arg Phe  Lys Asn Glu 
    1130                 1135                 1140             


Ile Ala  Ala Gly Leu Glu Ser  Lys Lys Ile Val Tyr  Asn Lys Phe 
    1145                 1150                 1155             


Gly Glu  Leu Leu Lys Tyr Ser  Glu Leu Asn Ser Asp  Ile Gln Ala 
    1160                 1165                 1170             


Lys Ile  Val Asp Ile Arg Asn  Met Leu Ala His Asn  Lys Tyr Met 
    1175                 1180                 1185             


Asp Asn  Ile Glu Arg Val Val  Asp Lys Asp Asp Met  Thr Leu Pro 
    1190                 1195                 1200             


Gln Val  Leu Glu Lys Ile Ile  Glu Trp Leu Gln Asp  Asn Ser Lys 
    1205                 1210                 1215             


Lys Ile  Thr His Thr Asp Glu  Ser Thr Asn Thr 
    1220                 1225                 


<210>  2262
<211>  1146
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2262

Met Glu Ser Ile Ile Gly Leu Gly Leu Ser Phe Asn Pro Tyr Lys Thr 
1               5                   10                  15      


Ala Asp Lys His Tyr Phe Gly Ser Phe Leu Asn Leu Ala Asp Asn Asn 
            20                  25                  30          


Leu Lys Ala Val Phe Ala Glu Phe Lys Glu Arg Ile Ser Asp Lys Ser 
        35                  40                  45              


Lys Asp Glu Asp Ile Ser Asn Leu Ile Glu Lys His Phe Ile Asp Asn 
    50                  55                  60                  


Met Ser Ile Val Asp Tyr Glu Lys Asn Ile Ser Ile Leu Asn Gly Tyr 
65                  70                  75                  80  


Leu Pro Ile Ile Asp Phe Leu Asp Asp Glu Leu Glu Asn Asn Leu Asn 
                85                  90                  95      


Thr Arg Val Lys Asn Phe Lys Lys Ser Phe Ile Ile Leu Ala Glu Ala 
            100                 105                 110         


Leu Glu Thr Leu Arg Asn Tyr Tyr Thr His Phe Tyr His Asp Pro Ile 
        115                 120                 125             


Thr Phe Gly Asp Asn Lys Glu Pro Leu Leu Glu Leu Leu Asp Glu Val 
    130                 135                 140                 


Leu Leu Lys Thr Ile Leu Asp Val Lys Lys Lys Tyr Leu Lys Thr Asp 
145                 150                 155                 160 


Lys Thr Lys Glu Ile Leu Lys Asp Ser Leu Arg Glu Glu Met Asp Leu 
                165                 170                 175     


Leu Val Ile Arg Lys Thr Asp Glu Leu Arg Glu Lys Lys Lys Thr Asn 
            180                 185                 190         


Pro Lys Phe Lys Phe Ser Thr Asp Pro Thr Gln Ile Arg Asn Ser Ile 
        195                 200                 205             


Phe Asn Asp Ala Phe Gln Gly Leu Leu Tyr Glu Asp Lys Glu Asn Asn 
    210                 215                 220                 


Gly Lys Thr Gln Val Ser Tyr Arg Ala Lys Thr Lys Leu Asn Pro Lys 
225                 230                 235                 240 


Asp Ile His Lys Gln Glu Glu Arg Asp Phe Glu Ile Pro Leu Ser Thr 
                245                 250                 255     


Ser Gly Ile Val Phe Leu Met Ser Leu Phe Leu Ser Lys Lys Glu Ile 
            260                 265                 270         


Glu Asp Phe Lys Ser Asn Ile Lys Gly Phe Lys Gly Lys Val Val Lys 
        275                 280                 285             


Asp Glu Asn His Asn Ser Leu Lys Tyr Met Ala Thr His Arg Val Tyr 
    290                 295                 300                 


Ser Ile Leu Ala Phe Lys Gly Leu Lys Tyr Arg Ile Lys Thr Asp Thr 
305                 310                 315                 320 


Phe Ser Lys Val Thr Leu Met Met Gln Met Ile Asp Glu Leu Ser Lys 
                325                 330                 335     


Val Pro Asp Cys Val Tyr Gln Asn Leu Ser Glu Thr Lys Gln Lys Asp 
            340                 345                 350         


Phe Ile Glu Asp Trp Asn Glu Tyr Leu Lys Asp Asn Glu Glu Asn Thr 
        355                 360                 365             


Glu Asn Leu Glu Asn Ser Arg Val Val His Pro Leu Ile Arg Lys Arg 
    370                 375                 380                 


Tyr Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe 
385                 390                 395                 400 


Ala Asn Phe Lys Thr Leu Lys Phe Gln Val Phe Met Gly Tyr Tyr Ile 
                405                 410                 415     


His Asp Gln Arg Thr Lys Thr Ile Gly Thr Thr Asn Ile Thr Thr Glu 
            420                 425                 430         


Arg Thr Val Lys Glu Lys Ile Asn Val Phe Gly Lys Leu Ser Lys Met 
        435                 440                 445             


Asp Asn Leu Lys Lys His Phe Phe Ser Gln Leu Ser Asp Glu Glu Asn 
    450                 455                 460                 


Thr Asp Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Phe Leu Thr Gln 
465                 470                 475                 480 


Ala Asp Asn Ser Pro Ala Asn Asn Ile Pro Ile Tyr Leu Glu Leu Lys 
                485                 490                 495     


Asn Gln Gln Ile Ile Lys Glu Lys Asp Asp Ile Lys Ala Glu Val Asn 
            500                 505                 510         


Asn Ser Gln Asn Arg Asn Pro Asn Lys Pro Ser Lys Arg Asp Leu Leu 
        515                 520                 525             


Asn Lys Ile Ser Asn Thr Asn Glu Asp Phe Tyr Gln Gly Asp Pro Thr 
    530                 535                 540                 


Ala Ile Leu Ser Leu Asn Glu Ile Pro Ala Leu Leu His Leu Phe Leu 
545                 550                 555                 560 


Val Gln Pro Asp Asn Lys Thr Gly Gln Gln Ile Glu Asn Ile Ile Arg 
                565                 570                 575     


Ile Lys Ile Glu Lys Gln Phe Asn Ser Ile Lys Asn Pro Ser Lys Asp 
            580                 585                 590         


Asp Lys Gly Val Pro Lys Ser Leu Phe Ala Asp Thr Asn Val Arg Val 
        595                 600                 605             


Asn Ala Ile Lys Leu Lys Lys Asp Leu Gly Glu Glu Leu Asp Met Leu 
    610                 615                 620                 


Asn Lys Lys Gln Ile Val Phe Lys Glu Asn Gln Lys Ala Ser Ser Asn 
625                 630                 635                 640 


Tyr Asp Glu Leu Leu Lys Lys His Gln Phe Thr Pro Lys Asn Lys Arg 
                645                 650                 655     


Pro Ala Leu Arg Lys Tyr Val Phe Tyr Asn Ser Glu Lys Gly Glu Glu 
            660                 665                 670         


Ala Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Lys Gly Phe 
        675                 680                 685             


Lys Thr Lys Trp Lys Gly Tyr Gln His Ser Glu Leu Gln Arg Lys Leu 
    690                 695                 700                 


Ala Phe Tyr Asp Arg His Thr Lys Gln Asp Ile Lys Glu Leu Leu Ser 
705                 710                 715                 720 


Gly Cys Glu Phe Asp His Phe Leu Leu Asp Ile Asn Ala Cys Phe Lys 
                725                 730                 735     


Glu Asp Asp Phe Glu Asp Phe Phe Ser Lys Tyr Leu Lys Asn Arg Ile 
            740                 745                 750         


Glu Thr Leu Asn Ile Ile Leu Lys Gln Leu His Asp Phe Lys Asn Glu 
        755                 760                 765             


Pro Thr Pro Leu Lys Gly Val Phe Lys Asn Cys Leu Lys Phe Leu Lys 
    770                 775                 780                 


Gln Lys Asn Tyr Val Thr Glu Asn Pro Glu Ile Ile Lys Lys Arg Ile 
785                 790                 795                 800 


Leu Ala Lys Pro Ala Phe Leu Pro Arg Gly Ile Phe Asp Glu Arg Pro 
                805                 810                 815     


Thr Met Lys Lys Gly Lys Asn Pro Leu Ile Asp Arg Asp Glu Phe Ala 
            820                 825                 830         


Lys Trp Phe Val Glu Tyr Leu Glu Asn Lys Asp Tyr Gln Lys Phe Tyr 
        835                 840                 845             


Asn Ser Glu Glu Tyr Arg Ile Arg Asp Ala Asp Phe Lys Lys Asn Ala 
    850                 855                 860                 


Val Ile Lys Lys Gln Lys Leu Lys Asp Phe Tyr Thr Leu Gln Met Val 
865                 870                 875                 880 


Asn Tyr Leu Leu Lys Glu Val Phe Gly Lys Asp Glu Met Asn Leu Gln 
                885                 890                 895     


Leu Ser Glu Leu Phe Gln Thr Arg Gln Glu Arg Leu Lys Leu Gln Gly 
            900                 905                 910         


Ile Ala Lys Lys Gln Met Asn Lys Glu Thr Gly Asp Ser Ser Glu Asn 
        915                 920                 925             


Thr Arg Asn Gln Thr Tyr Ile Trp Asn Lys Asp Val Pro Val Ser Phe 
    930                 935                 940                 


Phe Asn Gly Lys Val Thr Ile Asp Lys Val Lys Leu Lys Asn Ile Gly 
945                 950                 955                 960 


Lys Tyr Lys Arg Tyr Glu Arg Asp Glu Arg Val Lys Thr Phe Ile Gly 
                965                 970                 975     


Tyr Glu Val Asp Glu Lys Trp Met Met Tyr Leu Pro His Asn Trp Lys 
            980                 985                 990         


Asp Arg Tyr Ser Val Lys Pro Ile  Asn Val Ile Asp Leu  Gln Ile Gln 
        995                 1000                 1005             


Glu Tyr  Glu Glu Ile Arg Ser  His Glu Leu Leu Lys  Glu Ile Gln 
    1010                 1015                 1020             


Asn Leu  Glu Gln Tyr Ile Tyr  Asp His Thr Thr Asp  Lys Asn Thr 
    1025                 1030                 1035             


Leu Leu  Gln Asp Gly Asn Pro  Asn Phe Lys Met Tyr  Val Leu Asn 
    1040                 1045                 1050             


Gly Leu  Leu Thr Gly Ile Lys  Gln Val Asn Ile Ala  Asp Phe Ile 
    1055                 1060                 1065             


Val Leu  Lys Gln Asn Thr Asn  Phe Asp Lys Ile Asp  Phe Thr Gly 
    1070                 1075                 1080             


Ile Ala  Ser Cys Ser Glu Leu  Glu Lys Lys Thr Ile  Ile Leu Ile 
    1085                 1090                 1095             


Ala Ile  Arg Asn Lys Phe Ala  His Asn Gln Leu Pro  Asn Lys Thr 
    1100                 1105                 1110             


Ile Tyr  Asp Leu Ala Asn Glu  Phe Leu Lys Lys Glu  Lys Arg Glu 
    1115                 1120                 1125             


Thr Tyr  Ala Asn Tyr Tyr Leu  Lys Val Leu Lys Lys  Met Ile Ser 
    1130                 1135                 1140             


Asp Leu  Ala 
    1145     


<210>  2263
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2263

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2264
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2264

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Leu Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2265
<211>  1130
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2265

Met Glu Thr His Thr Glu Arg Val Ser Val Thr Tyr Asp Tyr Thr Glu 
1               5                   10                  15      


Lys Ala Asp Lys His Tyr Phe Ala Gly Phe Leu Asn Gln Ala Asp Leu 
            20                  25                  30          


Asn Phe Arg Thr Ala Leu Val Glu Leu Ala Lys Arg Cys Gly Ile Glu 
        35                  40                  45              


His Gly Val Asn Arg Ala Asn Glu Gly Gln Asn Asp Glu Lys Glu Thr 
    50                  55                  60                  


Ile Ser Trp Ile Asn Glu Thr Phe Asn Asp Lys Leu Ser Gln Thr Asp 
65                  70                  75                  80  


Trp Asn Tyr Arg Thr Ser Leu Leu Ser Asn Phe Leu Pro Phe Val Arg 
                85                  90                  95      


Glu Ile Ser Tyr Lys Glu Asn Thr Ser Val Thr Arg Asp Ala Phe Arg 
            100                 105                 110         


Ser Asp Leu Ile Leu Leu Tyr Glu Asn Leu Met Ile Leu Arg His Tyr 
        115                 120                 125             


Tyr Thr His Lys Phe His Asp Glu Lys Lys Leu Glu Arg Lys Val Phe 
    130                 135                 140                 


Gly Val Leu Asp Tyr Leu Ile Leu Gln Ala Ala His Thr Val Arg Asn 
145                 150                 155                 160 


Arg Arg Leu Arg Asn Ala Ile Tyr Lys Pro Ala Leu Pro Lys Gln Phe 
                165                 170                 175     


Glu Glu Asp Tyr Leu Glu Ala Glu Lys Ser Phe Ile Lys His Asn Gln 
            180                 185                 190         


Glu Val Glu Ala Leu Arg Gln Thr Glu Lys Leu Lys Ala Asp Phe Asp 
        195                 200                 205             


Ile Lys Gln Phe Arg Lys Lys His Pro Thr Tyr Lys Glu Glu Asp Phe 
    210                 215                 220                 


His Ser Ile Tyr Leu Asn Arg Ala Val Ser Glu Ile Leu Asp Lys Asn 
225                 230                 235                 240 


Lys Asp Thr Gly Glu Phe Ser Leu Lys Asp Ser Gln Arg Ser Glu Arg 
                245                 250                 255     


Ala Glu Lys Asp Asp Lys Leu Ser Gln Asn Gly Phe Val Phe Phe Leu 
            260                 265                 270         


Cys Leu Phe Leu Ser Arg Lys Asp Ala Glu Asp Leu Leu Asp His Thr 
        275                 280                 285             


Thr Asn Phe Lys Ala Ser Tyr Arg Leu Arg Tyr Leu Val Lys Arg Trp 
    290                 295                 300                 


Thr Tyr Thr Val Phe Cys Tyr Val Gly Ile Arg His Thr Leu Arg Ser 
305                 310                 315                 320 


Glu Phe Ser Lys Glu Ala Leu Leu Leu Gln Met Val Asp Glu Leu Ser 
                325                 330                 335     


Lys Cys Pro Ala Glu Leu Phe Glu Val Leu Pro Glu Asp Lys Gln Gln 
            340                 345                 350         


Glu Phe Val Met Asp Arg Asn Glu Tyr Phe Lys Asp Asn Asp Glu Asp 
        355                 360                 365             


Gly Asn Thr Pro Glu Glu Ser Phe Val Ser His Leu Ile Ile Arg Lys 
    370                 375                 380                 


Arg Tyr Gln Asp Arg Phe Pro Tyr Phe Ala Ile Arg Phe Leu Asp Glu 
385                 390                 395                 400 


Phe Ala Asn Phe Gln Ser Leu Arg Phe Gln Leu Arg Leu Gly Lys Tyr 
                405                 410                 415     


Lys His Asp Thr Arg Thr Lys Thr Phe Lys Gly Ile Glu Thr Thr Thr 
            420                 425                 430         


Glu Arg Ser Ile Lys Glu Glu Ile Lys Val Phe Gly Lys Leu Ser Glu 
        435                 440                 445             


Val His Lys Ser Lys Glu Glu Tyr Phe Glu Ala Lys Pro Glu Ala Asp 
    450                 455                 460                 


Glu Lys Thr Ile Lys Gly Trp Leu Gln Tyr Pro Asn Val Ser Tyr Val 
465                 470                 475                 480 


Ile Asp Asn Asn Asn Ile Pro Ile Tyr Leu Asp Lys Phe Thr Gln Lys 
                485                 490                 495     


Glu Asn Phe Pro Ile Asp Arg Ser Arg Lys Ile Glu Ile Ile Asn Glu 
            500                 505                 510         


Leu His Ile Asn Glu Ile Ile Arg Ser Glu Ala Pro His Ala Phe Leu 
        515                 520                 525             


Ser Ile Asn Glu Leu Pro Ala Cys Ile Tyr Leu Phe Met Glu Glu Ala 
    530                 535                 540                 


Ser Lys Lys Lys Arg His Pro Asn Ser Glu Arg Glu Leu Leu Thr Asn 
545                 550                 555                 560 


Pro Ile Gly Val Gly Ile Glu Asn Arg Ile Leu Gly Lys Val Gln Ser 
                565                 570                 575     


Gln Tyr Lys Phe Ile Gln Thr Val Asp Tyr Asn Ser Gln Leu Ser Asp 
            580                 585                 590         


Lys Asn Thr Pro Lys Arg Phe Ile Lys Ser Leu Lys Glu Gly Lys Thr 
        595                 600                 605             


Asn Gly Glu Ile Asp Tyr His Arg Leu Thr Asn Ala Ile Lys Lys Gln 
    610                 615                 620                 


Ile Glu Asp Cys Asp Gln Arg Leu Ile Trp Leu Asn Ser Lys Lys Glu 
625                 630                 635                 640 


Glu Gln Lys Asn Arg Glu Lys Lys Asp Gln Asn Thr Leu Lys Ser Arg 
                645                 650                 655     


Phe Ile Leu Asn Ser Lys Glu Ile Gly Glu Thr Ala Met Trp Leu Ala 
            660                 665                 670         


Lys Asp Ile Lys Arg Tyr Val Ser Lys Thr Asp Arg Lys Asn Trp Lys 
        675                 680                 685             


Ser Arg His Gln Ala Glu Leu Gln Ala Leu Phe Ala Phe Tyr Asp Lys 
    690                 695                 700                 


Lys Lys Gln Gln Thr Glu Ser Leu Leu Arg Asp Glu Met Gly Ile Asp 
705                 710                 715                 720 


Leu Ser Glu Tyr Ser Phe Leu Lys Asp Met Phe Leu Glu Pro Ser Phe 
                725                 730                 735     


Val Ser Val Tyr Asn Phe Tyr Leu Ile Lys Lys Arg Glu Leu Leu Asn 
            740                 745                 750         


Ser Tyr Val Leu Leu Ile Glu Asn Asn Thr Gly Asn Tyr Gln Gln Lys 
        755                 760                 765             


Ala Val Arg Lys Glu Ile Asn Lys Ile Phe Asp His Phe Asp Arg Ser 
    770                 775                 780                 


Lys Tyr Ser Tyr Ile Asp Ser Ala Tyr His Ser Asn Leu Leu Gln Lys 
785                 790                 795                 800 


Pro Val Asn Leu Pro Arg Gly Leu Phe Asp Asp Lys Lys Glu Phe Ser 
                805                 810                 815     


Ser Lys Gly Asp Lys Glu Gly Arg Gln Ser Trp Phe Ala Leu Ala Glu 
            820                 825                 830         


Asp Ala Pro Lys Gln Val Phe Tyr Ser Tyr Ser Arg Ala Tyr Gln Ile 
        835                 840                 845             


Gln Asp Met Asp Gly Lys Thr Ile Lys Met Lys Glu Phe Glu Met His 
    850                 855                 860                 


Glu Asn Ile Asn Glu Lys Ala Asp Phe Asp Thr Glu Leu Lys Lys His 
865                 870                 875                 880 


Ile Val Thr Thr Glu Lys Arg Ile Arg Lys Ile Ala Arg Gln Asp Tyr 
                885                 890                 895     


Tyr Leu Leu Gln Met Val Lys Phe Leu Phe Glu Glu Leu Gly Ile Lys 
            900                 905                 910         


Phe Thr Glu Asp Ile Thr Leu Ser Asp Ala Phe Phe Glu Arg Asp Asn 
        915                 920                 925             


Ile Arg Lys Asn Ile Gln Ile Ser His Gly Gln Ser Lys Arg Glu Lys 
    930                 935                 940                 


Gly Asp Tyr Ser Glu Asn Ile Tyr Arg Val Ser Asn Leu Leu Glu Thr 
945                 950                 955                 960 


Arg Ile Asn Ile Asn Leu Phe Gly Gly Lys Ile Pro Val Met Asn Ile 
                965                 970                 975     


Arg Leu Lys Asp Val Gly Lys Tyr Arg Ala Leu Glu Lys Asp Glu Arg 
            980                 985                 990         


Ile Lys Lys Leu Leu Ser Tyr Ser  Asp Arg Asn Tyr Ser  Thr Ile Asp 
        995                 1000                 1005             


Glu Leu  Ile Lys Glu Ile Asp  Asn Tyr Glu Tyr Ile  Arg Arg His 
    1010                 1015                 1020             


Glu Ile  Leu Lys Ala Val His  Lys Leu Glu His Thr  Ile Tyr Thr 
    1025                 1030                 1035             


Leu Ala  Lys Glu Asn Asn Glu  Thr Asp Lys Leu Gln  Asp Gly Asn 
    1040                 1045                 1050             


Pro Asn  Phe Thr Glu Tyr Leu  Lys Tyr Tyr Tyr Ser  Gln Ile Asn 
    1055                 1060                 1065             


Glu Ala  Ile Ala Asn Ile Ser  Asp Asp Pro Leu Ile  Ile Val Arg 
    1070                 1075                 1080             


Asn Arg  Leu Ser His Asn Gln  Leu Pro Glu Leu Ser  Glu Tyr Asn 
    1085                 1090                 1095             


Ile Ile  Lys Ala Gln Ser Pro  Arg Asn Glu Thr Glu  Leu Ile Gly 
    1100                 1105                 1110             


Asp Tyr  Leu Leu Arg Val Phe  Asn Ser Phe Asn Asn  Ser Leu Ile 
    1115                 1120                 1125             


Ser Met  
    1130 


<210>  2266
<211>  1138
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2266

Met Glu Thr Leu Tyr Asn Ser Thr Asn Glu Asn Ser Arg Arg Asn Leu 
1               5                   10                  15      


Asn Asp Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Leu Ala Arg Leu 
            20                  25                  30          


Asn Ile Phe Ser Ile Asn Asn His Leu Ala Glu Glu Phe Lys Gln Lys 
        35                  40                  45              


Asn Arg Leu Thr Asp Glu Glu His Ile Arg Asn Ser Phe Ile Cys Asn 
    50                  55                  60                  


Ser Asn Ile Lys Asn Leu Asn Tyr Asn Trp Leu Phe Glu Lys Leu Ile 
65                  70                  75                  80  


Arg Leu Met Pro Ile Val Lys Gln Phe Asp Ser Ser Arg Leu Pro Glu 
                85                  90                  95      


Glu Glu Gln Lys Lys Gly Asp Thr Glu Gly Lys Asn Leu Leu Leu Met 
            100                 105                 110         


Ala Glu Thr Leu Lys Glu Val Phe Lys Asp Ile Gln Asp Phe Arg Asn 
        115                 120                 125             


Asp Tyr Thr His Tyr Tyr Ser Val Glu Lys Gly Asp Glu Arg Lys Leu 
    130                 135                 140                 


Asn Val Ser Ser Ala Thr Ala Asp Phe Leu Val Thr Ser Phe His Arg 
145                 150                 155                 160 


Ala Ile Glu Tyr Thr Lys Ser Arg Phe Ala Asn Val Phe Ser Glu Asp 
                165                 170                 175     


Asp Phe Lys Leu Ile Gln Ala Lys Gln Leu Val Leu Ser Asn Asn Ser 
            180                 185                 190         


Ile Thr Val Glu Gly Leu Val Phe Leu Thr Ala Met Phe Leu Asp Arg 
        195                 200                 205             


Glu Asn Ala Phe Gln Phe Ile Gly Lys Val Gln Gly Leu Lys Gly Thr 
    210                 215                 220                 


Gln Phe Lys Ser Phe Ile Ala Ser Arg Glu Val Leu Met Ala Tyr Cys 
225                 230                 235                 240 


Val Arg Leu Pro His Asp Lys Leu Ile Ser Asp Asp Pro Lys Gln Ala 
                245                 250                 255     


Leu Leu Leu Asp Met Leu Asn Glu Leu Asp Arg Cys Pro Lys Leu Leu 
            260                 265                 270         


Tyr Asn Val Leu Ser Glu Asp Ala Lys Lys Gln Phe Arg Pro Ile Leu 
        275                 280                 285             


Thr Lys Gln Ser Ile Glu Gln Val Leu Glu Asn Ser Val Ser Asp Glu 
    290                 295                 300                 


Glu Arg Glu Asn Ile Leu Asp Asn Ile Asp Tyr Ser Glu Tyr Ile Glu 
305                 310                 315                 320 


Gln Leu Thr Val Arg Val Arg His Ser Asn Arg Phe His Tyr Phe Ala 
                325                 330                 335     


Met Arg Phe Ile Asp Glu Gln Asn Leu Leu Pro Asp Phe Phe Phe Gln 
            340                 345                 350         


Ile Asp Leu Gly Lys Tyr Lys Leu Ser Glu Tyr Glu Lys Ser Ile Leu 
        355                 360                 365             


Gly Gln Ser Ile Pro Arg Ser Ile Ile Glu Asn Ala Lys Ala Phe Gly 
    370                 375                 380                 


Arg Leu Ser Lys Phe Val Ser Glu Asp Asp Val Gln Lys Ile Ile Asp 
385                 390                 395                 400 


Pro Gly Asn Leu Ala Asn Gly Phe Glu Gln Phe Ala Pro His Tyr Asn 
                405                 410                 415     


Thr Asp Ile Asn Lys Ile Gly Phe Arg Phe Asn Glu Asp Ile Cys His 
            420                 425                 430         


Ile Glu Ser Ile Asp Ala Lys Ala Glu Arg Arg Ile Ser Val Asn Leu 
        435                 440                 445             


Ile Gln Pro Gln Pro Met Gly Phe Leu Ser Leu His Glu Leu Ser Lys 
    450                 455                 460                 


Ile Ile Leu Leu Glu Tyr Leu Gln Pro Gly Glu Ser Ile Lys Leu Ile 
465                 470                 475                 480 


Arg Gln Phe Tyr Lys Thr Ala Asn Thr Gln Leu Phe Asn Ile Asp Phe 
                485                 490                 495     


Ile Glu Leu Val Lys Thr Lys Leu Pro Thr Asn Trp Gly Asp Leu Glu 
            500                 505                 510         


Lys Gln Cys Asp Thr Lys Asn Asn Lys Ala Tyr Arg Asn Ser Lys Ala 
        515                 520                 525             


Ser Leu Tyr Glu Leu Gln Lys Arg Lys Glu Glu Leu Asp Lys Val Leu 
    530                 535                 540                 


Gln Phe His Gly Leu Asn Trp Thr Gln Ile Pro Glu Arg Ile Leu Asn 
545                 550                 555                 560 


Tyr Trp Leu Asn Ile Gln Asp Val Ser Tyr Ser Lys Ser Ile Ser Glu 
                565                 570                 575     


Arg Ile Leu Leu Met Lys Arg Asp Gly Leu Lys Arg Leu Lys Gln Leu 
            580                 585                 590         


Lys Asn His Ser Asn Arg Pro Asp Val Arg Ile Pro Lys Val Gly Glu 
        595                 600                 605             


Met Ala Thr Phe Ile Ala Arg Asp Ile Val Asp Met Ile Ile Asp Glu 
    610                 615                 620                 


Glu Lys Lys Lys Lys Ile Thr Ser Ile Tyr Tyr Asp Lys Leu Gln Glu 
625                 630                 635                 640 


Cys Leu Ala Phe Tyr Ala Asp Lys Glu Lys Lys Gln Gln Leu Ile Gly 
                645                 650                 655     


Leu Val Arg Glu Leu Gln Leu Asn Leu Gln Gly Gly His Pro Phe Leu 
            660                 665                 670         


Lys Asn Leu Arg Leu Glu Ser Ile Arg Lys Thr Ser Glu Phe Tyr Glu 
        675                 680                 685             


Leu Tyr Leu Thr Glu Lys Phe Ser Lys Leu Val His Lys Gly Leu Asn 
    690                 695                 700                 


Gln Lys Gly Lys Pro Gln Ser Arg Asp Glu Ser Trp Ile Ile Arg Thr 
705                 710                 715                 720 


Phe Glu Lys Lys Glu Trp Ser Asp Lys Ala Lys Lys Asn Leu Thr Val 
                725                 730                 735     


Tyr Lys Phe Pro Asp Asn Met Lys Glu Leu Pro Phe Ser Met Gln Gln 
            740                 745                 750         


Trp Ile Asn Lys Glu Gln Tyr Asp Leu Arg Gly Trp Leu Arg Asn Ile 
        755                 760                 765             


Asn Glu Gly Arg Asn Arg Asn Asp Gln Lys Arg Pro Ile Asp Leu Pro 
    770                 775                 780                 


Thr Asn Leu Phe Asn Asn Lys Leu Cys Glu Leu Leu Thr Gln Glu Leu 
785                 790                 795                 800 


Arg Leu Ala Gly Lys Ala Ile Pro Asn Thr Thr Lys Tyr Tyr Glu Leu 
                805                 810                 815     


Leu Arg Val Trp Trp Leu Asn Arg Asp Asp Ser Val Gln Gly Phe Tyr 
            820                 825                 830         


Lys Gly Ser Arg Ser Tyr Ile Ile Lys Asp Glu Leu Val Ser Phe Ile 
        835                 840                 845             


Pro Asp Ser Gln Pro Asn Phe Lys Lys Tyr Tyr Gln Glu Pro Leu Asn 
    850                 855                 860                 


Lys Ala Phe Ile Arg Leu Ser Gln Lys Arg Gln Met Asp Arg Glu Lys 
865                 870                 875                 880 


Asp Lys Lys Leu Pro Val Leu Asp Lys Thr Asp Ile Glu Lys Thr Phe 
                885                 890                 895     


Lys Lys Thr Leu Phe Asp Thr Glu Lys Asn Ile Arg Leu Leu Ala Glu 
            900                 905                 910         


Asp Asp Arg Ile Leu Leu Leu Met Ala Glu Lys Leu Ser Pro Gly Asp 
        915                 920                 925             


Gly Ser Gly His Leu Lys Leu Asn Asn Ile Lys Lys Glu Leu Asn Lys 
    930                 935                 940                 


Glu Gln Ile Lys Glu Arg Ala Phe Gln Phe Arg Pro Asn Tyr Asp Asp 
945                 950                 955                 960 


Ala Gly Asn Met Pro Glu Lys Gly Val Leu Leu Pro Glu Ile Gln Leu 
                965                 970                 975     


Ile Val Glu Ala Lys Ile Arg Leu Lys Asn Ile Lys Asp Leu Asn Arg 
            980                 985                 990         


Phe Ala Tyr Asp Arg Arg Leu Pro  Glu Leu Ile Ala Tyr  Leu Pro Asn 
        995                 1000                 1005             


Gly Lys  Ile Gly Val Asn Glu  Leu Arg Tyr Glu Leu  Thr Asp Tyr 
    1010                 1015                 1020             


Asn Lys  Ala Arg Gln Glu Val  Phe Asp Glu Val Phe  Arg Leu Glu 
    1025                 1030                 1035             


Lys Thr  Ile Ile Gln Lys Asp  Ala Asp Gly Leu Leu  Ala Leu Cys 
    1040                 1045                 1050             


Val Asn  Glu Arg Gly Ile Pro  Leu Arg Gly Asn Ile  Ala His Lys 
    1055                 1060                 1065             


Tyr Phe  Leu Gln Trp Leu Ile  Asn His Gly Tyr Ile  Ser Glu Gln 
    1070                 1075                 1080             


Glu Arg  Lys Tyr Leu Asn Met  Ile Arg Asn Ser Phe  Ser His Asn 
    1085                 1090                 1095             


Gln Phe  Pro His Lys Leu Ile  Val Ser Tyr Ser Gln  Asn Gln Ile 
    1100                 1105                 1110             


Asn Gln  Lys Gly Ile Ala Ser  Ile Ile Ser Ser Ala  Phe Lys Glu 
    1115                 1120                 1125             


Lys Thr  Glu Ser Ile Ile Tyr  Lys Ile Asp 
    1130                 1135             


<210>  2267
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2267

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2268
<211>  1173
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2268

Met Gly Lys Asp Tyr Lys Thr Gln Gln Pro Lys Lys Val Arg Arg Gln 
1               5                   10                  15      


Gln Lys Thr Asn Phe Ser Ile Asn Leu Thr Gly Lys His Val Phe Gly 
            20                  25                  30          


Ala Tyr Phe Asn Met Ala Arg Thr Asn Phe Val Lys Thr Ile Asn Tyr 
        35                  40                  45              


Ile Met Pro Ile Ala Gly Val Arg Gly Ser Tyr Ser Glu Asn Gln Ile 
    50                  55                  60                  


Asn Lys Met Leu His Ala Leu Phe Leu Ile Gln Ala Gly Arg Ser Gly 
65                  70                  75                  80  


Glu Leu Thr Asn Glu Gln Arg Gln Trp Glu Lys Lys Leu Arg Leu Asn 
                85                  90                  95      


Thr Glu Gln Gln Thr Arg Leu Gln Lys Leu Leu Phe Lys His Phe Pro 
            100                 105                 110         


Val Leu Gly Pro Met Met Ala Asp Val Ala Asp His Lys Ala Phe Leu 
        115                 120                 125             


Asn Lys Lys Lys Ser Lys Val Gln Thr Glu Glu Asp Lys Phe Ala Gln 
    130                 135                 140                 


Leu Lys Gly Val Ser Leu Ala Asp Cys Leu Asp Val Ile Cys Leu Met 
145                 150                 155                 160 


Ala Asp Ala Leu Thr Glu Cys Arg Asn Phe Tyr Thr His Lys Ala Pro 
                165                 170                 175     


Tyr Asn Ala Pro Ser Gln Leu Ala Ala Gln Tyr Gln His Gln Glu Met 
            180                 185                 190         


Ile Ala Lys Lys Leu Asp Lys Val Val Val Ala Cys Arg Arg Val Leu 
        195                 200                 205             


Lys Asp Arg Glu Gly Leu Ser Val Asn Glu Val Glu Phe Leu Thr Gly 
    210                 215                 220                 


Ile Asp His Leu His Gln Glu Val Val Lys Asp Glu Ser Gly Asn Val 
225                 230                 235                 240 


Lys Lys Lys Asn Gly Lys Val Met Lys Thr Phe Val Glu Tyr Asp Asp 
                245                 250                 255     


Phe Tyr Phe Lys Ile Ser Gly Lys Arg Leu Val Lys Gly Phe Thr Val 
            260                 265                 270         


Ala Val Lys Asp Asp Lys Pro Val Asn Ile Asp Thr Met Leu Pro Ala 
        275                 280                 285             


Leu Ser Asp Phe Gly Leu Leu Tyr Phe Cys Val Leu Phe Leu Ser Lys 
    290                 295                 300                 


Pro Tyr Ala Lys Leu Phe Ile Asp Glu Val Arg Leu Phe Glu Phe Ser 
305                 310                 315                 320 


Pro Phe Thr Asp Thr Glu Asn Met Ile Met Ser Glu Met Leu Ser Ile 
                325                 330                 335     


Tyr Arg Ile Arg Thr Pro Arg Leu His Lys Ile Asp Ser Arg Asp Asn 
            340                 345                 350         


Lys Ala Thr Leu Ala Met Asp Ile Phe Gly Glu Leu Arg Arg Cys Pro 
        355                 360                 365             


Ile Glu Leu Tyr Glu Leu Leu Asp Lys Asn Met Gly Gln Pro Phe Phe 
    370                 375                 380                 


His Asp Glu Val Lys His Pro Asn Ser His Thr Pro Glu Val Ser Lys 
385                 390                 395                 400 


Arg Leu Arg Tyr Asn Asp Arg Phe Pro Thr Leu Ala Leu Arg Tyr Ile 
                405                 410                 415     


Asp Glu Asn Glu Leu Phe Lys His Ile Arg Phe Gln Leu Gln Leu Gly 
            420                 425                 430         


Ala Phe Arg Tyr Arg Phe Tyr Asp Lys Glu Asp Cys Ile Asp Gly Ile 
        435                 440                 445             


Val Arg Val Arg Arg Ile Gln Lys Asp Ile Asn Gly Tyr Gly Arg Leu 
    450                 455                 460                 


Gln Glu Val Ala Asp Lys Arg Ile Glu Lys Trp Gly Asp Leu Ile Gln 
465                 470                 475                 480 


Lys Arg Glu Glu His Ala Val Lys Leu Glu His Glu Glu Leu Tyr Ile 
                485                 490                 495     


Asp Leu Asp Gln Phe Val Glu Asp Thr Ala Asp Ser Thr Pro Tyr Val 
            500                 505                 510         


Thr Asp Arg Arg Pro Ser Tyr Asn Ile His Ala Asn Arg Ile Gly Leu 
        515                 520                 525             


Tyr Trp Glu Asp Ser Gln Asn Pro Lys Ser Tyr Lys Ile Phe Asp Glu 
    530                 535                 540                 


Asn Gly Met Tyr Ile Pro Glu Leu Val Val Thr Glu Asp Glu Lys Ala 
545                 550                 555                 560 


Pro Ile Lys Met Pro Ala Pro Arg Cys Thr Leu Ser Val Tyr Asp Leu 
                565                 570                 575     


Ser Ala Met Leu Phe Tyr Glu Tyr Leu His Glu Gln Gln Asp Val Asp 
            580                 585                 590         


Thr Pro Ser Ala Glu Arg Ile Ile Ile Asp Cys Glu Asp Asp Tyr Arg 
        595                 600                 605             


Arg Phe Phe Lys Ala Val Ala Glu Gly Thr Leu Thr Pro Phe Lys Lys 
    610                 615                 620                 


Thr Lys Glu Phe Arg Glu Tyr Leu Glu Arg Glu Tyr Pro Lys Leu Arg 
625                 630                 635                 640 


Met Ala Asp Ile Pro Glu Lys Leu Gln Leu Tyr Leu Thr Ser Lys Gly 
                645                 650                 655     


Leu Thr His Asp Asn Lys Pro Glu Thr Val His Glu Arg Met Ile Arg 
            660                 665                 670         


Leu Thr Arg Glu His Leu Glu Glu Arg Glu Ile His Val Gln Arg Arg 
        675                 680                 685             


Leu Glu His Tyr Gln Glu Asp Arg Lys Met Ile Gly Glu Lys Glu Asn 
    690                 695                 700                 


Lys Tyr Gly Lys Lys Ser Phe Ala Asp Val Arg His Gly Ala Leu Ala 
705                 710                 715                 720 


Arg Tyr Leu Ala Gln Ser Met Met Glu Trp Gln Pro Thr Lys Leu Lys 
                725                 730                 735     


Asp Lys Glu Lys Gly His Asp Lys Leu Thr Gly Leu Asn Tyr Asn Val 
            740                 745                 750         


Leu Thr Ala Tyr Leu Ala Thr Tyr Gly His Pro Gln Val Ser Glu Glu 
        755                 760                 765             


Asp Phe Val Ser Leu Thr Leu Glu Gln Val Leu Thr Asn Ala His Leu 
    770                 775                 780                 


Leu Gly Gly Asn Asn Pro His Pro Phe Ile Gly Lys Val Leu Ala Leu 
785                 790                 795                 800 


Gly Asn Arg Asn Ile Glu Glu Leu Tyr Leu His Tyr Leu Glu Glu Glu 
                805                 810                 815     


Leu Lys His Ile Arg Ser Arg Lys Gln Ser Leu Leu Ser Asn Pro Ser 
            820                 825                 830         


Asp Lys Ala Leu Ser Ala Leu Pro Phe Val His Tyr Asp Arg Val Arg 
        835                 840                 845             


Phe His Glu Arg Thr Asp Glu Glu Met Arg Ala Leu Ala Ala Arg Tyr 
    850                 855                 860                 


Thr Thr Ile Gln Leu Pro Asp Gly Leu Phe Thr Pro Tyr Ile Leu Glu 
865                 870                 875                 880 


Ile Leu Lys Lys His Tyr Thr Glu Asn Thr Glu Leu Gln Asn Ala Leu 
                885                 890                 895     


Arg Gln Asp Ala Thr Ala Lys Ile Asn Pro Thr Asn Asn Ala Ala Tyr 
            900                 905                 910         


Leu Ile Thr Leu Phe Tyr Lys Thr Val Leu Lys Asp Asp Ala Gln Pro 
        915                 920                 925             


Phe Tyr Ile Ser Gly Lys Ala Tyr Thr Arg Asn Lys Asp Gly Glu Lys 
    930                 935                 940                 


Ala Glu Ala Phe Ser Phe Lys Arg Ser Tyr Glu Leu Phe Ser Val Leu 
945                 950                 955                 960 


Asn Asn Asn Lys Lys Lys Thr Phe Pro Tyr Glu Leu Leu Pro Leu Phe 
                965                 970                 975     


Leu Thr Ser Asp Glu Ile Gln Glu Arg Leu Ser Ala Lys Leu Leu Asp 
            980                 985                 990         


Asp Asn Gly Asn Pro Ile Pro Glu  Ala Gly Lys Arg Gly  Lys Pro Ala 
        995                 1000                 1005             


Thr Asp  Ile Gln Gly Asn Thr  Ile Trp Gln Arg Gln  Ile Lys Gln 
    1010                 1015                 1020             


Lys Ile  Asn Gly Tyr Val Asn  Ser Leu Ser Asp Lys  Asp Leu Lys 
    1025                 1030                 1035             


Ile Ser  Met Asn Gln Ser Trp  Lys Lys Lys Glu Glu  Glu Arg Ala 
    1040                 1045                 1050             


Ala Lys  Arg Glu Ala Met Gln  Ser Arg Leu Thr Lys  Gln Ile Asn 
    1055                 1060                 1065             


Glu Val  Lys Gly Asn Glu Arg  Thr Leu Arg Arg Tyr  Lys Thr Gln 
    1070                 1075                 1080             


Asp Met  Val Leu Phe Leu Met  Ala Lys Glu Leu Phe  Ala Thr Ile 
    1085                 1090                 1095             


Ile Ser  Asp Gln Gly Asn Glu  Val Asn Trp Lys Gln  Met Arg Leu 
    1100                 1105                 1110             


Ser Lys  Val Cys Asn Glu Ala  Phe Leu Arg Gln Thr  Leu Thr Ile 
    1115                 1120                 1125             


Arg Val  Pro Val Thr Val Gly  Asn Thr Thr Ile Tyr  Val Glu Gln 
    1130                 1135                 1140             


Glu Asn  Met Ser Leu Lys Asn  Tyr Gly Glu Phe Tyr  Arg Phe Leu 
    1145                 1150                 1155             


Thr Asp  Asp Arg Leu Met Ser  Leu Leu Asn Ile Ile  Val Glu Thr 
    1160                 1165                 1170             


<210>  2269
<211>  1134
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2269

Met Asn Glu Thr Asp Tyr Leu Ala Lys Arg Leu Glu Tyr Asn Tyr Ala 
1               5                   10                  15      


Ser Ile Glu Asp Lys His Tyr Phe Gly Gly Tyr Phe Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asn Asp Leu Ser Lys Ala Phe Lys Glu Lys Phe Gly Met 
        35                  40                  45              


Lys Pro Lys Ser Cys Ile Leu Asp Phe Phe Thr Gln Asp Lys Ala Ile 
    50                  55                  60                  


Ala Glu Tyr Gln Leu Gly Val Glu Phe Leu Gln Lys Asn Leu Pro Val 
65                  70                  75                  80  


Ile Arg Tyr Leu Tyr Leu Pro Thr Ser His Lys Arg Phe Glu Asn Val 
                85                  90                  95      


Pro Lys Asn Gln Leu Ile Ser Glu Gln Arg Asn Tyr Phe Lys Asn Ser 
            100                 105                 110         


Leu Lys Val Leu Lys Asn Leu Ile Arg Asp Tyr Arg Asn Phe Tyr Thr 
        115                 120                 125             


His His Phe His Lys Pro Ile Pro Val Phe Pro Glu Thr Tyr Lys Leu 
    130                 135                 140                 


Leu Asp Asp Leu Phe Leu Ala Val Ala Asn Asp Val Lys Lys His Arg 
145                 150                 155                 160 


Met Lys Thr Asp Ala Ser Lys Gln Leu Leu Lys Lys Gly Leu Ile Glu 
                165                 170                 175     


Glu Leu Ala Gln Leu Glu Lys Leu Lys Leu Glu Asp Leu Lys Lys Leu 
            180                 185                 190         


Lys Arg Glu Gly Lys Lys Val Asn Leu Asn Asp Lys Glu Ala Ile Thr 
        195                 200                 205             


Asn Ala Ile Leu Asn Asp Ser Phe Ser His Leu Leu Pro Lys Glu Asn 
    210                 215                 220                 


Thr Ile Ser Lys Tyr Tyr Ser Ala Val Pro Thr Glu Asp Ile Asp Thr 
225                 230                 235                 240 


Glu Asn Gly Val Thr Ile Ser Glu Ser Gly Ile Ile Phe Leu Leu Gly 
                245                 250                 255     


Leu Phe Leu Thr Lys Lys Gln Ser Glu Asp Leu Arg Ser Arg Val Lys 
            260                 265                 270         


Gly Phe Lys Ala Lys Leu Ile Val Asn Pro Glu Asn Pro Ile Asn Lys 
        275                 280                 285             


Lys Asn Asn Ser Leu Lys Tyr Met Ala Thr His Trp Val Phe Gly Tyr 
    290                 295                 300                 


Leu Gly Phe Lys Gly Leu Lys Asn Arg Phe Thr Thr Thr Phe Thr Lys 
305                 310                 315                 320 


Asp Thr Leu Leu Ala Gln Ile Val Asp Glu Leu Ser Lys Val Pro Asp 
                325                 330                 335     


Glu Leu Tyr Gln Val Leu Pro Glu Glu Leu Lys Asn Glu Phe Leu Glu 
            340                 345                 350         


Asp Met Asn Glu Tyr Leu Lys Glu Glu Asn Ser Glu Ser Leu Asp Lys 
        355                 360                 365             


Ala Thr Val Ile His Pro Val Ile Arg Lys Arg Tyr Glu Asn Lys Phe 
    370                 375                 380                 


Ala Tyr Phe Ala Leu Arg Phe Leu Asp Glu Phe Val Asp Phe Pro Thr 
385                 390                 395                 400 


Leu Arg Phe Gln Leu His Leu Gly Asn Tyr Val His Asp Lys Arg Glu 
                405                 410                 415     


Lys Pro Ile Glu Gly Thr Lys Tyr Val Thr Glu Arg Ile Val Lys Glu 
            420                 425                 430         


Lys Ile Lys Ala Phe Ala Lys Leu Ser Glu Ala Ala Gln Leu Lys Gln 
        435                 440                 445             


Lys Tyr Phe Glu Glu Lys Glu Asn His Gln Ser Ile Gly Leu Gln Leu 
    450                 455                 460                 


Tyr Pro Asn Pro Ser Tyr Asn Phe Val Gly Asn Asn Ile Pro Ile His 
465                 470                 475                 480 


Leu Asn Leu Asn Glu His Phe Phe Pro Lys Glu Val Lys Ile Val Ala 
                485                 490                 495     


Gly Arg Leu Lys Lys Arg Asn Ser Ser Tyr Lys Ser Asp His Pro Glu 
            500                 505                 510         


Glu Tyr Lys Val Arg Thr Asp Asn Lys Ile Lys Pro Asp Ala Ile Leu 
        515                 520                 525             


Gln Asp Leu Gly Lys Pro Glu Lys Leu Ala Pro Val Ala Met Leu Ser 
    530                 535                 540                 


Leu Asn Glu Leu Pro Ala Leu Leu His Leu Val Leu Thr Lys Lys Thr 
545                 550                 555                 560 


Pro Glu Glu Ile Glu Ile Ile Ile Ala Gln Lys Ile Ala Glu Arg Tyr 
                565                 570                 575     


Asn Val Leu Thr Asn Tyr Lys Ala Gly Asp Asp Ile Ser Lys Gly Gln 
            580                 585                 590         


Ile Thr Lys Asn Leu Leu Lys Ala Lys Gln Lys Lys Glu Val Asn Leu 
        595                 600                 605             


Asp Lys Leu Gln Leu Ala Ile Glu Lys Glu Ile Ala Val Thr Asn Asp 
    610                 615                 620                 


Lys Leu Gln Thr Ile Ala Leu His Ile Lys Glu Arg Asn Asp Pro Lys 
625                 630                 635                 640 


Gln Lys Arg Lys Tyr Val Phe Thr Asn Lys Glu Ile Gly Leu Gln Val 
                645                 650                 655     


Thr Trp Leu Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Gly Ser Arg 
            660                 665                 670         


Gln Asn Trp Arg Gly Gln His His Ser Gln Leu Gln Lys Ser Leu Ala 
        675                 680                 685             


Phe Tyr Asp Ile Gln Pro Lys Glu Pro Leu Ser Leu Leu Glu Glu Val 
    690                 695                 700                 


Trp Asp Phe Lys Asn Glu Ala Tyr Leu Trp Asn Asn Gly Ile Arg Arg 
705                 710                 715                 720 


Ser Phe Asp Lys Arg Asp Phe Ile Ser Phe Tyr Thr Ser Tyr Leu Asn 
                725                 730                 735     


Asn Arg Lys Glu Thr Phe Gln Arg Phe Lys Asp Gln Leu Asn Gly Ile 
            740                 745                 750         


Arg Ser Asn Lys Lys Ile Leu Asp Lys Phe Ile Lys Gln Gln His Leu 
        755                 760                 765             


Trp Asn Leu Phe His Lys Arg Leu Tyr Val Ile Asp Thr Ile Glu Glu 
    770                 775                 780                 


Gln Val Glu Lys Leu Leu Val Lys Pro Met Gln Phe Pro Lys Gly Val 
785                 790                 795                 800 


Phe Asp His Lys Pro Thr Tyr Ile Lys Gly Lys Ser Ile Gln Glu Asn 
                805                 810                 815     


Pro Glu Cys Phe Ala Asp Trp Tyr Val Ala Trp Asn Gln His Thr Asp 
            820                 825                 830         


Tyr Gln Lys Phe Tyr Ser Trp Asp Arg Asp Tyr Lys Ser Ala Tyr Leu 
        835                 840                 845             


Ser Gly Glu Gln Glu Lys Thr Glu Lys Arg Phe Ile Arg Val Gln Gly 
    850                 855                 860                 


Ser Lys Ile Asn Lys Val Lys Gln Gln Asp Val Leu Leu Ala Lys Met 
865                 870                 875                 880 


Ala Ser Ile Ile Phe Asn Glu Leu Tyr Leu Pro Glu Asp Ala Glu His 
                885                 890                 895     


Leu Asp Leu Asn Leu Ser Asp Ile Tyr Lys Thr Gln Thr Glu Arg Lys 
            900                 905                 910         


Ala Glu Ile Glu Ala Ala Leu Ile Gln Ser His Lys Thr Thr Gly Asp 
        915                 920                 925             


Asn Ser Ala Asn Ile Ile Lys Ser Thr Ser Ala Trp Thr Leu Thr Val 
    930                 935                 940                 


Pro Tyr Cys Ser Lys Asn Ile Tyr Glu Pro Gln Val Lys Leu Lys Glu 
945                 950                 955                 960 


Leu Gly Lys Phe Lys Lys Phe Ile Ala Ser Gln Lys Val Gln Thr Leu 
                965                 970                 975     


Phe Glu Tyr Lys Pro Gln Lys Ile Trp Asn Lys Thr Glu Leu Glu Glu 
            980                 985                 990         


Val Leu Glu Leu Lys Ala Asn Ser  Tyr Glu Val Ile Arg  Arg Asp Tyr 
        995                 1000                 1005             


Leu Leu  Lys Ser Ile Gln Glu  Phe Glu Lys Tyr Met  Ile Lys Lys 
    1010                 1015                 1020             


Leu Pro  Thr Leu Ile Asp Thr  Asn Glu His Pro Asn  Phe Asn Lys 
    1025                 1030                 1035             


Tyr Leu  Thr Thr Phe Leu Lys  Ser Leu Glu Leu Val  Ser Glu Glu 
    1040                 1045                 1050             


Asp Ala  Lys Trp Leu Ile Ser  Lys Lys Asp Phe Asp  Thr Thr Pro 
    1055                 1060                 1065             


Ile Asp  Glu Leu Lys Lys Gln  Ser Lys Ile Met Glu  Lys Ala Phe 
    1070                 1075                 1080             


Leu Leu  Val Met Ile Arg Asn  Lys Phe Ser His Asn  Gln Leu Pro 
    1085                 1090                 1095             


Arg Lys  Ile Tyr Tyr Asp Glu  Ile Tyr Lys Asn Val  Pro Asn Ala 
    1100                 1105                 1110             


Val Ser  Ile Asn Phe Asn Glu  Leu Phe Leu Glu Tyr  Thr Asn Gln 
    1115                 1120                 1125             


Thr Ile  Leu Glu Phe Lys 
    1130                 


<210>  2270
<211>  1131
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2270

Met Glu Glu Leu Ser Glu Phe Asp Leu Phe Thr Gly Gly Lys Arg Pro 
1               5                   10                  15      


Glu Phe Ala Val Phe Tyr Asn Val Ala Leu Thr Arg Ala Ile Gly Ile 
            20                  25                  30          


Leu Asn Tyr Tyr Ala His Pro Asn Thr Lys Glu Leu Gln Asn Phe Thr 
        35                  40                  45              


Glu Lys Ala Phe Lys Thr Lys Phe Glu Glu Trp Ile Thr Ile Lys Lys 
    50                  55                  60                  


Gln Leu Pro Thr Glu Pro Ala Tyr His Glu Met Ala Asn Tyr Leu Trp 
65                  70                  75                  80  


Lys Ser Phe Asp Leu Arg Glu Asn Asp Gln Gly Tyr Ala Leu Thr Asp 
                85                  90                  95      


Leu Asp Lys Lys Met Thr Ala Glu Leu Leu Leu Lys Leu Tyr Glu Ile 
            100                 105                 110         


Arg Asp Phe His Ser His Ala Tyr His Asp Asn Ile Ala Leu Lys Val 
        115                 120                 125             


Ser Ala Glu Phe Val Lys Phe Ile Glu Ser Met His Asp Arg Ala Leu 
    130                 135                 140                 


Asp Lys Ala Arg Glu Lys Tyr Asp Thr Thr Asp Tyr Glu Lys Met Tyr 
145                 150                 155                 160 


Cys Gly Lys Asn Ala Arg Phe Gly Phe Phe Arg Asp Val Tyr Pro Asp 
                165                 170                 175     


Phe Phe Ile Thr Gln Glu Gly Arg Ala Phe Leu Leu Ser Leu Phe Leu 
            180                 185                 190         


Thr Lys Gly Glu Met Thr Leu Phe Leu Gln Gln Lys Lys Gly Ser Lys 
        195                 200                 205             


Arg Asn Asp Lys Asp Glu Phe Lys Val Lys His Phe Val Tyr Arg Tyr 
    210                 215                 220                 


Phe Thr His Arg Glu Gly Ser Ala Arg Arg Trp Ile Ser Gln Glu Glu 
225                 230                 235                 240 


Ala Met Leu Asp Val Leu Pro Glu Asp Met Lys Asn Gln Val Gln Ser 
                245                 250                 255     


Ala Arg Lys Ala Tyr Lys Val Leu Ser Tyr Leu Ala Asp Gln Pro Glu 
            260                 265                 270         


Leu Ser Thr Leu Ser Ala Leu Asn Ile Ser Asp Arg Pro Gly Asn Ala 
        275                 280                 285             


Gly Asp Thr Thr Ser Ile Phe Cys Leu Lys Asn Gly Thr Leu Val His 
    290                 295                 300                 


Asn Ala Met Asp Leu Ile Ala Phe Cys Lys Glu Tyr Asp Leu Phe His 
305                 310                 315                 320 


Gly Val Gln Ala Thr Glu Glu Lys Gly Arg Ile His Ile Thr Val Asp 
                325                 330                 335     


Cys Asn Gly Arg Ala Phe Val Leu Asp Phe Leu Glu Ala Asp Ile Lys 
            340                 345                 350         


Lys Val Ala Leu Asp Phe Phe Arg Ser Ser Asp Lys Arg Ala Tyr Asn 
        355                 360                 365             


Thr Ser Phe Arg Glu Lys Leu Asp Glu Trp Ala Gln Ser Arg Asn His 
    370                 375                 380                 


Leu Leu Asp Ile Leu Tyr Met Thr Glu Arg Ser Thr Pro His Thr Ile 
385                 390                 395                 400 


Glu Asp Ala Glu Thr Ser Leu Phe Glu Glu Leu Glu Ser Tyr Tyr Lys 
                405                 410                 415     


Gln Lys Leu Met Gly Gly Pro Ile Leu Arg Glu Lys Leu Gly Arg Trp 
            420                 425                 430         


Ile Asp Ile Ile Gln Lys Asn His Gly Val Asp Asn Ala Ala Gln Phe 
        435                 440                 445             


Arg Glu Phe Val Glu Arg Val Arg Asn Glu Thr Ile Trp Val Ser His 
    450                 455                 460                 


Tyr Asp Leu Phe Ala Thr Glu Asn His Lys Pro Arg Ser Ser Asp Lys 
465                 470                 475                 480 


Phe Met Leu Phe Ala Val His Tyr Leu Met Asp Trp Gly Asn Thr Gly 
                485                 490                 495     


Trp Glu Trp Gly Phe Lys Asn Pro Ala Thr Ile Glu Lys Thr Glu Arg 
            500                 505                 510         


Glu Lys Asn Arg Leu Leu Leu Lys Leu Asp Asn Glu Lys Leu Ala Gln 
        515                 520                 525             


Ala Leu Ala Leu Asp Arg Glu Thr Lys Gly Gly Glu Thr Pro Thr Ile 
    530                 535                 540                 


Asp Val Ala Thr Glu Arg Glu Arg Leu Arg Ile Ser Ala Gly Leu Val 
545                 550                 555                 560 


Val Tyr Ala Ala Gln Lys Pro Gln Gly Thr Arg Leu Ala Leu Lys Glu 
                565                 570                 575     


Gly Gln Ala Leu Leu Arg Ala Glu Asp Gln Leu Phe Leu Ile Gly Pro 
            580                 585                 590         


Val Ala Met Arg Asn Leu Leu Ile Ala Phe Leu Ile Asp Gly Lys Asp 
        595                 600                 605             


Ile Lys His Phe Phe Lys Pro Leu Ala Met Asp Met Lys Lys Ile Gly 
    610                 615                 620                 


Glu Ala Ile Lys Ser Lys Ala Glu Leu Pro Glu Asn Leu Glu Leu Ile 
625                 630                 635                 640 


Gly Ser His Glu Met Pro Glu Thr Met Arg Lys Ala Leu Lys Asn Ser 
                645                 650                 655     


Lys Lys Thr Tyr Ser Asn Glu Asn Ser Ile Ala Gln Ala Arg Lys Lys 
            660                 665                 670         


Ile Asn Arg Ile Ile Asp Glu Val Ile Arg Pro Leu Gln Asn Gly Ala 
        675                 680                 685             


Ala Asp Lys Leu Ser Arg Ala Glu Lys Asn Arg Lys Ile Met Asp Met 
    690                 695                 700                 


Tyr Leu Tyr Tyr Asp Trp Lys Tyr Ala Asn Asn Asp Asp Phe Lys Phe 
705                 710                 715                 720 


Leu Arg Arg His Glu Tyr Gln Gln Met Ser Val Tyr His Tyr Leu Leu 
                725                 730                 735     


Glu Lys His Lys Arg Asn Glu Tyr Gly Phe Leu Ile Asp Gly Ile Met 
            740                 745                 750         


Gly His Ile Pro Gln Glu Ile Leu Leu Leu Leu Asn Lys Ala Arg Asp 
        755                 760                 765             


Met Asp Gly Leu Leu Gln Ser Leu Cys Val Glu Thr Thr Lys Arg Leu 
    770                 775                 780                 


Asn Asp Trp Arg Glu Leu Leu Asp Met Arg Asp Leu Pro Phe Arg Lys 
785                 790                 795                 800 


Lys Arg Glu Ile Leu Glu Lys Leu Ser Val Thr Leu Pro Asp Lys Ser 
                805                 810                 815     


Leu Thr Leu Asn Pro Tyr Met Pro Val Pro Val His Pro Leu Trp Val 
            820                 825                 830         


Ile Lys Lys Tyr Tyr Lys Ala Glu Asn Glu Ala Gly Gly Phe Ser Leu 
        835                 840                 845             


Ser Tyr Lys Lys Ile Arg Glu Asn Gly Leu Ile Ser Ser Leu Lys Ala 
    850                 855                 860                 


Glu Asn Tyr Ala Trp Glu Ser Tyr Ser Glu Phe Leu Gly Gln His Pro 
865                 870                 875                 880 


Gln Lys Asp Lys Ile Thr Lys Lys Leu Lys Gly Ser Phe Asp Arg Leu 
                885                 890                 895     


Ile Thr Glu Asp Thr Leu Val Trp His Ile Gly Gln Lys Tyr Leu Glu 
            900                 905                 910         


Thr Met Met Pro Ala Trp Arg Asp Ala Leu Thr Glu Ala Val Gln Ala 
        915                 920                 925             


Gly Arg Asn Leu Arg Glu Thr Glu Val Lys Leu Asn Leu Ala Asp Leu 
    930                 935                 940                 


Thr Leu Val Leu Lys Tyr His Gln Leu Asp Asp Val Leu Leu Gln Glu 
945                 950                 955                 960 


Ser Lys Ala Thr Met Leu Lys Ile Ala Glu His Leu Lys Arg Ser Leu 
                965                 970                 975     


Pro Tyr Arg Glu Glu Lys Leu Lys Glu Phe Asp Pro Ala Lys Lys Ile 
            980                 985                 990         


Glu Asn Arg Phe Lys Phe Asn Ile  Asp Glu Asn Leu Ser  Glu Leu Pro 
        995                 1000                 1005             


Tyr Asp  Asp Val His Lys Glu  Arg Ser Arg Ile Ala  Ser Glu Ala 
    1010                 1015                 1020             


Leu His  Trp Ala Lys Tyr Ile  Leu Glu Trp Glu Leu  Ala Ala Val 
    1025                 1030                 1035             


Arg Ser  Met Leu Ser Ser Asp  Leu Gln Lys Trp Arg  Val Val Lys 
    1040                 1045                 1050             


Ser Gly  Tyr Pro Arg Ile Gly  Phe Arg Gln Val Met  Asp Tyr Cys 
    1055                 1060                 1065             


Ala Leu  Thr Asp Thr Leu Lys  Asp Leu Val Ala Lys  Ile Arg Asn 
    1070                 1075                 1080             


His Ser  Phe His Phe Val Ile  Pro Glu Gly Trp Cys  Tyr Ala Glu 
    1085                 1090                 1095             


Leu Glu  Lys Asn Glu Asp Leu  Cys Arg Leu Leu Lys  Tyr Val Pro 
    1100                 1105                 1110             


Lys Glu  Lys His Trp Arg Ala  Leu Glu Ala Lys Lys  Gln Ser Arg 
    1115                 1120                 1125             


Asn Leu  Ser 
    1130     


<210>  2271
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2271

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe His Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Arg Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Met Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2272
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2272

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Leu Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2273
<211>  1253
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2273

Met Leu Glu Ile Gln Ile Glu Lys Glu Lys Arg Gly Trp Phe Trp Ala 
1               5                   10                  15      


Met Asn Leu Thr Met Ala Leu Asn Asn Leu Glu Thr Ile Ala Lys Arg 
            20                  25                  30          


Ala Leu Asn Val Leu Gly Lys Pro Tyr Pro Ala Ser Gln Ser Glu Asp 
        35                  40                  45              


Glu Gln Thr Asn Ala Leu Lys Gln Ala Leu Asp Glu Leu Gln Lys Gln 
    50                  55                  60                  


Pro Leu Ile Cys Gln Thr Lys Ile Glu Arg Val Phe Phe Arg Ser Leu 
65                  70                  75                  80  


Pro His Leu Asn Lys Phe Arg Gln Phe Ile Glu Met Gly Gly Glu Lys 
                85                  90                  95      


Ser Ser Ala Ser Tyr Val Glu Lys Ser Ser Ser Arg Ala Asp Ala Glu 
            100                 105                 110         


Ala Thr Gln Arg Gln Ser Gly Arg Asp Phe Thr Ser Asp Asp Leu Phe 
        115                 120                 125             


Gln Leu Ala Arg Tyr Tyr Leu Lys Ser Leu Val Glu Leu Arg Asn Tyr 
    130                 135                 140                 


Phe Ala His Ser Glu His Gln Tyr Pro Lys Leu Pro Glu Ser Leu Asp 
145                 150                 155                 160 


Ile Lys Gly Val Arg Phe Pro Ser Ser Phe Glu Asn Ala Leu Phe Asn 
                165                 170                 175     


Ala Asn Val Arg Thr Val Lys Asp Arg Phe Tyr Lys Asp Asp Arg Lys 
            180                 185                 190         


Asp Ala Arg Glu Ile Glu Asn Gly Phe Leu Cys Phe Arg Pro Lys Lys 
        195                 200                 205             


Thr Val Lys Asn Arg Glu Thr Val Asp Asn Pro Glu Phe Lys Phe Arg 
    210                 215                 220                 


Leu Thr Glu Arg Asn Asp Ala Asn Gly Arg Arg Tyr Pro Thr Gln Ala 
225                 230                 235                 240 


Gly Leu Ala Phe Phe Val Ala Arg Phe Leu Glu Lys Arg Tyr Val Asp 
                245                 250                 255     


Leu Leu Phe Glu Thr Thr Asp Ala Asn Gly Val Pro Val Leu Pro Leu 
            260                 265                 270         


His Arg Pro Gln Asp Val Asp Gly Val Glu Phe Ser Leu Ala Pro Arg 
        275                 280                 285             


Arg Val Tyr Gly Leu Asn Ala Ala Arg Leu Pro Arg Arg Arg Val Glu 
    290                 295                 300                 


Thr Thr Ala Arg Pro Glu Ser Ser Asn Glu Thr Leu Gly Leu Asp Leu 
305                 310                 315                 320 


Ile Gly Tyr Leu Ala Arg Cys Pro Lys Arg Val Tyr Glu Phe Leu Ser 
                325                 330                 335     


Glu Thr Asp Arg Arg Lys Phe Arg Val Ala Ala Asp Glu Ser Asn Pro 
            340                 345                 350         


Ser Glu Gly Leu Arg Thr Arg Ser Glu Lys Arg Phe Ala Arg Leu Ala 
        355                 360                 365             


Ala Leu Cys Leu Asp Arg Met Asn Cys Phe Glu Asn Leu Arg Phe Gln 
    370                 375                 380                 


Val Asp Met Gly Gln Tyr Tyr Ser Ala Thr His Arg Arg Arg Leu Ile 
385                 390                 395                 400 


Asp Gly Thr Thr Ile Asp Asp Arg Arg Val Gly Lys Arg Val Phe Trp 
                405                 410                 415     


Phe Glu Arg Ile Gln Asn Ala Val Asp Tyr Tyr Arg Ala Glu Arg Leu 
            420                 425                 430         


Lys Pro Glu Ser Lys Tyr Phe Val Pro Thr Asp Glu Ala Glu Thr Pro 
        435                 440                 445             


Pro Glu Thr Asp Tyr Arg Val Asp Ala Tyr Pro Arg Tyr Arg Val Lys 
    450                 455                 460                 


Asn Gln Gln Leu Gly Leu Arg Leu Val Asp Ala Ser Gln Lys Asn Ala 
465                 470                 475                 480 


Pro Pro Lys Leu Ile Pro Trp Thr His Ser Ala Lys Arg Gly Ser Ala 
                485                 490                 495     


Pro Lys Thr Arg Met Lys Arg Pro Glu Phe Trp Leu Ser Gln Tyr Glu 
            500                 505                 510         


Leu Pro Ala Leu Leu Phe Val Ala Leu His Gly Lys Ala Gln Asp Ala 
        515                 520                 525             


Gln Asn Val Ile Ala Asp Tyr Gln Lys Asn Trp Arg Arg Phe Leu Glu 
    530                 535                 540                 


Asp Val Arg Asp Gly Lys Phe Asp Phe Gly Gly Gly Arg Ala Leu Arg 
545                 550                 555                 560 


Glu Thr Arg Gln Thr Phe Glu Ser Gln Tyr Gly Leu Arg Phe Asp Asp 
                565                 570                 575     


Leu Pro Asp Ser Thr Arg Ala Leu Phe Arg Ser Thr Ala Ser Asp Ser 
            580                 585                 590         


Lys Glu Leu Glu Lys Lys Arg Val Asp Ala Ala Glu Gln Thr Leu Pro 
        595                 600                 605             


Glu Arg Gln Ile Asp Arg Leu Leu Asp Glu Thr Arg Arg Arg Leu Ala 
    610                 615                 620                 


Val Leu Glu Ser Glu Thr Arg Glu Val Phe Gln Leu Gly Lys Arg Lys 
625                 630                 635                 640 


Arg Pro Ser Leu Ser Val Gly Arg Val Ala Ser Cys Leu Val Arg Asp 
                645                 650                 655     


Leu Met Arg Phe Gln Tyr Ala Thr Ser Glu Lys Ser Phe Gly Lys Ile 
            660                 665                 670         


Pro Ser Ser Pro Asp Phe Ile Ala Leu Gln Thr Ser Leu Ala Cys Phe 
        675                 680                 685             


Glu Ser Arg Gln Asn Glu Leu Leu Glu Ile Phe Lys Ala Ala Lys Leu 
    690                 695                 700                 


Ile Pro Ser Asn Phe Val Ala Pro Asn Asp Ala Glu Glu Ala Phe Phe 
705                 710                 715                 720 


Phe Ala Asp Ala Gln Asn Ala Glu Arg Ser Leu His Pro Phe Leu Gly 
                725                 730                 735     


Ala Val Val Ala Asp Ala Ala Asn Leu Arg Asp Trp Lys Ser Phe Tyr 
            740                 745                 750         


Arg Ala Tyr Leu Thr Cys Arg Leu Asn Trp Leu Arg Gly Cys Ala Pro 
        755                 760                 765             


Gln Glu Leu Arg His Thr Arg Tyr Gly Asn Arg Arg Leu Glu Lys Leu 
    770                 775                 780                 


Lys Lys Met Arg Lys Ser Gly Lys Arg Gln Thr Val Ala Gln Gln Met 
785                 790                 795                 800 


Ala Thr Arg Leu Leu Glu Gln Pro Ile Asn Leu Pro Arg Gly Leu Phe 
                805                 810                 815     


Thr Asp Leu Val Arg Ala Val Val Gln Glu Arg Phe Gly Asp Gln Leu 
            820                 825                 830         


Ala Lys Ala Thr Gln Asn Gly Ala Thr Ser Thr Asn Ala Ser Trp Leu 
        835                 840                 845             


Ile Gly Lys Val Arg Asp Trp Ser Asp Asp Ala Ser Gln Gly Phe Tyr 
    850                 855                 860                 


Ser Trp Arg Arg Asp Tyr Arg Asn Val Ala Ser Phe Lys Arg Leu Phe 
865                 870                 875                 880 


Glu Leu Cys Gly Pro Thr Val Ser Thr Ser Pro Leu Ala Phe Arg Ala 
                885                 890                 895     


Leu Asn Ser Thr Ser Pro Leu Asp Phe Arg Ala Leu Lys Glu Ala Phe 
            900                 905                 910         


Asp Ala Asn Phe Asp Ala Asn Tyr Ala Ala Ala Glu Phe Ala Lys Thr 
        915                 920                 925             


Asp His Lys Thr Asp Arg Glu Asp Trp Glu Arg Phe Ile Arg Glu Ala 
    930                 935                 940                 


Glu Ala Glu Leu Arg Glu Glu Ala Leu Glu Ala Thr Arg Gly Arg Ser 
945                 950                 955                 960 


Gln Arg Arg Pro Phe Ile Pro Arg Glu Lys Ile Glu Glu Arg Ala Ser 
                965                 970                 975     


Lys Lys Arg Lys Lys Phe Ala Asp Glu Gln Lys Ala Lys Arg Arg Ala 
            980                 985                 990         


Ala Glu His Ala Lys Ile Arg Arg  Leu Ser Asp Ala Glu  Arg Asp Ile 
        995                 1000                 1005             


Arg His  Ala Glu Ile Gln Asp  Tyr Val Leu Leu Leu  Ala Ala Ser 
    1010                 1015                 1020             


Tyr Phe  Leu Phe Glu Gly Asp  Leu Ala Lys Ile Arg  Leu Ala Asp 
    1025                 1030                 1035             


Val Tyr  Ala Ile Val Asp Asp  Ala Thr Gly Thr Val  Ser Thr Asn 
    1040                 1045                 1050             


Pro Leu  Arg Lys Leu Arg Pro  Cys Glu Val Leu Val  Asp Val Pro 
    1055                 1060                 1065             


Gly Ser  Gly Thr Cys Lys Ile  Arg Gly Glu Met Asn  Val Lys Asn 
    1070                 1075                 1080             


Ser Gly  Asn Phe Gln Arg Phe  Leu Thr Asp Gly Arg  Leu Pro Ser 
    1085                 1090                 1095             


Phe Leu  Arg Ser Leu Arg Leu  Met Gln Ala Glu Asn  Ala Glu Glu 
    1100                 1105                 1110             


Leu Ser  Tyr Ile Asp Leu Ala  Asn Glu Phe Ala Ala  Ser Asp Arg 
    1115                 1120                 1125             


Leu Gln  Arg Gly Arg Ile Phe  Ala Ala Ile Tyr Arg  Phe Glu Asn 
    1130                 1135                 1140             


Ala Cys  Phe Ser Val Phe Pro  Glu Leu Lys Asp Lys  Lys Arg Gly 
    1145                 1150                 1155             


Gly Tyr  Val Ser Phe Ala Thr  Ile Leu Thr Ser Val  Phe Pro Asn 
    1160                 1165                 1170             


Asp Glu  Glu Thr Gln Tyr Arg  Leu Leu Val Ile Arg  Asn Lys Phe 
    1175                 1180                 1185             


Met His  Gln Glu Tyr Pro Ile  Tyr Asp Ala Ser Gln  Thr Lys Asp 
    1190                 1195                 1200             


Lys Gln  Arg Trp Thr Pro Ile  Phe Asp Arg Trp Asn  Arg Glu Met 
    1205                 1210                 1215             


Trp Ala  Lys Tyr Asp Pro Lys  His Gly Arg Ala Leu  Cys Gln Cys 
    1220                 1225                 1230             


Ala Val  Asp Trp Ala Glu Pro  Tyr Phe Asp Glu Ala  Thr Lys Leu 
    1235                 1240                 1245             


Val Glu  Ser Arg Arg 
    1250             


<210>  2274
<211>  1128
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2274

Met Glu Thr Gln Ile Ser Asn Ile Glu Asn Lys Tyr Arg Ile Leu Asn 
1               5                   10                  15      


Asp Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Val Phe Asn Ile Ser Asn His Ile Ala Lys Glu Phe Asn Leu Pro Leu 
        35                  40                  45              


Leu Pro Glu Glu Gly His Leu Lys Asn Ser Phe Leu Cys Gln Lys Glu 
    50                  55                  60                  


Asn Lys Lys Val Asn Trp Asn His Ile Phe Ser Lys Thr Asn Arg Phe 
65                  70                  75                  80  


Leu Ser Ile Leu Lys Val Phe Asp Val Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Lys Met Thr Asp Ser Glu Gly Lys Asp Phe Ala Leu Met Ser Asp 
            100                 105                 110         


Ser Leu Lys Ile Val Phe Gly Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Asn Gly Thr Ser Arg Lys Thr Thr Val 
    130                 135                 140                 


Ser Asp Glu Met Ser Leu Phe Leu Arg Thr Asn Phe Leu Arg Ala Ile 
145                 150                 155                 160 


Gln Tyr Thr Lys Glu Arg Phe Lys Gly Val Leu Asn Asp Glu Asp Tyr 
                165                 170                 175     


Gln Leu Val Ala Ser Lys Lys Val Leu Glu Ala Asp Asn Thr Ile Thr 
            180                 185                 190         


Val Glu Gly Leu Val Phe Leu Thr Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Thr Gly Leu Lys Gly Thr Gln Asn 
    210                 215                 220                 


Asn Ser Phe Ile Ser Thr Arg Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro His Asp Arg Phe Gln Ser Asp Asp Thr Arg Gln Ala Phe Ser 
                245                 250                 255     


Leu Asp Leu Ile Asn Glu Leu Thr Arg Cys Pro Lys Glu Leu Tyr Asn 
            260                 265                 270         


Ala Ile Thr Glu Glu Gly Lys Met Lys Phe Gln Pro Lys Leu Asp Glu 
        275                 280                 285             


Pro Gly Ile Lys Asn Leu Leu Asp Asn Ser Thr Asn Asn Lys Lys Lys 
    290                 295                 300                 


Ile Asp Ala Glu Asp Tyr Asp Glu Tyr Ile Glu Ser Leu Thr Lys Arg 
305                 310                 315                 320 


Ile Arg Tyr Asn Asn Arg Phe Ser Asp Phe Ala Leu Lys Tyr Ile Glu 
                325                 330                 335     


Glu Thr Asp Ile Leu Gly Asp Phe Arg Phe Gln Ile Asp Leu Gly Lys 
            340                 345                 350         


Leu Phe Val Asp Glu Tyr Asp Lys Phe Phe Asn Gly Glu Glu Val Pro 
        355                 360                 365             


Arg Arg Ile Ile Glu Asn Val Lys Ala Phe Gly Lys Leu Asn Asp Phe 
    370                 375                 380                 


Asn Asp Glu Ser Ile Leu Leu Ala Gln Ile Glu Asn Gly Tyr Pro Ser 
385                 390                 395                 400 


Lys Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Thr Glu Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Val Lys Val Asp Thr Ala Lys Leu Arg Ser Asn Ser 
            420                 425                 430         


Lys Gly Glu Pro Gly Lys Asn Leu Asn Gln Pro Leu Pro Glu Ala Phe 
        435                 440                 445             


Leu Ser Leu Asn Glu Leu Pro Lys Ile Ile Leu Leu Asp Tyr Leu Gln 
    450                 455                 460                 


Lys Gly Glu Pro Glu Gln Leu Ile Asn Asp Phe Ile Leu Ile Asn Asn 
465                 470                 475                 480 


Ser Lys Leu Met Lys Met Ser Phe Ile Glu Glu Ile Lys Asn Leu Leu 
                485                 490                 495     


Pro Lys Glu Trp Asn Glu Phe Arg Lys Arg Ala Asp Thr Arg Lys Gln 
            500                 505                 510         


Ala Ala Tyr Asn Asn Glu Thr Leu Ala Tyr Leu Leu Glu Arg Lys Gln 
        515                 520                 525             


Ile Leu Asn Gln Val Leu Val Ser Tyr Gln Leu Asn Asp Lys Gln Ile 
    530                 535                 540                 


Pro Gly Arg Ile Leu Asp Tyr Trp Leu Asn Ile Lys Glu Val Glu Glu 
545                 550                 555                 560 


Gly Arg Ala Val Ser Asp Arg Leu Lys Leu Met Lys Arg Asp Cys Met 
                565                 570                 575     


Ser Arg Leu Lys Ala Leu Glu Lys Phe Lys Ile Asp Arg Asn Arg Ser 
            580                 585                 590         


Lys Ile Pro Lys Thr Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile 
        595                 600                 605             


Val Asp Met Val Val Ser Glu Gly Ile Lys Lys Lys Ile Thr Ser Phe 
    610                 615                 620                 


Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Pro Glu 
625                 630                 635                 640 


Lys Lys Arg Leu Phe Ile His Ile Val Ile Arg Glu Leu Arg Leu Asn 
                645                 650                 655     


Gly Thr Gly Gly His Pro Phe Leu Phe Gln Leu Asn Phe Asp Lys Ile 
            660                 665                 670         


Asn Cys Thr Ser Asp Phe Tyr Ser Glu Tyr Leu Arg Glu Lys Gly His 
        675                 680                 685             


Lys Met Val Lys Glu Lys Asn Leu Lys Thr Gly Lys Ile Val Leu Thr 
    690                 695                 700                 


Asp His Ser Trp Met Ala Leu Thr Phe Tyr Lys Leu Glu Phe Asn Asp 
705                 710                 715                 720 


Lys Val Asp Lys Leu Met Thr Val Val Lys Leu Pro Leu Asn Lys Leu 
                725                 730                 735     


Asn Ile Pro Phe Thr Leu Arg Gln Leu Glu Gly Lys Thr Ile Asn Thr 
            740                 745                 750         


Leu Glu Gln Trp Leu Gln Asn Ile Thr Lys Gly Lys Asn Gln Asn Asp 
        755                 760                 765             


Gly Lys His Pro Val Asn Leu Pro Thr Asn Leu Phe Asp Glu Arg Leu 
    770                 775                 780                 


Thr Ala Cys Leu Gln Lys Glu Leu Asp Lys Lys Gln Ile Ile Tyr Pro 
785                 790                 795                 800 


Pro Tyr Ala Asn Trp Asn Glu Leu Phe Lys Thr Trp Trp Lys Ser Arg 
                805                 810                 815     


Asn Asp Ser Thr Gln Ser Phe Tyr Asn Ala Glu Arg Glu Tyr Ile Ile 
            820                 825                 830         


Phe Asp Glu Lys Val Asn Phe Tyr Pro Asn Arg Gln Glu Lys Phe Ala 
        835                 840                 845             


Asp Tyr Tyr His His Ala Val Lys Ala Ala Tyr Gln Lys Lys Arg Asn 
    850                 855                 860                 


Glu Arg Thr Leu Gln Gln Lys Asp Asp Lys His Leu Pro Asp Ile Leu 
865                 870                 875                 880 


Phe Ala Gln Val Glu Lys Thr Phe Lys Gln Thr Ile Ala Gly Thr Glu 
                885                 890                 895     


Lys Glu Ile Arg Met Val Gln Glu Glu Asp Arg Ile Met Leu Val Met 
            900                 905                 910         


Leu Glu Ser Leu Leu Glu Asp Gly Lys Lys Leu Gln Leu Lys Leu Ser 
        915                 920                 925             


Glu Ile Asn Thr Leu Leu Asn Ala Thr Thr Glu Ile Lys Gln Val Val 
    930                 935                 940                 


Thr Ala Lys Leu Ser Phe Asn Asp Ser Gly Glu Ile Ile Lys Asp Lys 
945                 950                 955                 960 


Thr Asn Pro Glu Ile Thr Lys Thr Ile Thr Ala Val Arg Lys Arg Lys 
                965                 970                 975     


Asp Tyr Ser Val Leu Arg Lys Phe Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Gly Tyr Phe Asp Gly Asp  Glu Ile Gln Phe Glu  Ser Leu Lys 
        995                 1000                 1005             


Ala Glu  Leu Asp Ala Tyr Asn  Lys Ala Lys Gln Glu  Val Leu Asp 
    1010                 1015                 1020             


Val Val  Phe Lys Leu Glu Lys  Lys Ile Ile Ala Lys  Asp Cys Asn 
    1025                 1030                 1035             


Gly Val  Gln Gln Leu Phe Ser  Asp Glu Thr Gly Asn  Leu Leu Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Thr Trp Leu  Lys Ser Lys 
    1055                 1060                 1065             


Gly Leu  Ile Gly Asp Ser Thr  Phe Thr Phe Leu Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Cys  Phe Ser His Asn Gln  Tyr Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Arg Phe  Ile Asp His Trp Glu  Thr Asn Arg Phe Ala  Leu Thr Ile 
    1100                 1105                 1110             


Ala Thr  Lys Tyr Asn His Glu  Ile Thr Arg Ile Met  Glu Lys Ile 
    1115                 1120                 1125             


<210>  2275
<211>  946
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2275

Val Leu Ser Pro Glu Gly Gln Lys Glu Phe Glu Asp Glu Val Val His 
1               5                   10                  15      


Glu Asn Glu Arg Thr Pro Glu Val Val Lys Arg Phe Arg Ser Thr Asp 
            20                  25                  30          


Arg Phe Pro Phe Leu Ala Leu Lys Tyr Ile Asp Glu Thr Lys Leu Phe 
        35                  40                  45              


Ser Asn Ile Arg Phe Gln Val Gln Leu Gly Lys Leu Arg Phe Lys Phe 
    50                  55                  60                  


Tyr Asp Lys Pro Cys Ile Asn Gly Glu Thr Asp Val Arg Ser Trp Gln 
65                  70                  75                  80  


Lys Asp Ile Asn Gly Phe Gly Arg Leu Gln Glu Ile Glu Glu Lys Arg 
                85                  90                  95      


Lys Gln Ile Tyr Lys Asp Trp Leu Gln Ala Ser Val Glu Arg Glu Val 
            100                 105                 110         


Lys Ile Glu Gly Glu Asp Ile Ser Leu Asp Leu Leu Gln Phe Glu Gln 
        115                 120                 125             


Asp Thr Ala Met Ser Arg Pro Tyr Ile Thr Asp Ser Arg Thr Ser Tyr 
    130                 135                 140                 


Asn Ile His Asn Asn Arg Ile Gly Leu Tyr Trp Val Glu Gly Val Ser 
145                 150                 155                 160 


Asn Gly His Gln Tyr Ala Lys Gly Gly Asp Tyr Leu Pro Asp Leu Ser 
                165                 170                 175     


Val Val Lys Asp Gly Asp Ala Pro Val Glu Met Pro Ala Pro Met Ala 
            180                 185                 190         


Met Leu Ser Ile Tyr Glu Leu Pro Ala Leu Phe Phe Tyr Gln Tyr Leu 
        195                 200                 205             


Gln Ser Ala Thr Lys Asp Ser Gly Ile Pro Ser Ala Glu Asp Phe Ile 
    210                 215                 220                 


Ile Met Lys Cys Arg Gly Leu Arg Gln Leu Phe Leu Asp Ile Ser Gln 
225                 230                 235                 240 


Gly Val Val Arg Pro Val Ser Arg Lys Thr Glu Leu Met Ala Lys Leu 
                245                 250                 255     


Lys Glu Gly Arg Tyr Gly Leu Thr Ile Ser Asp Ile Pro Glu Lys Leu 
            260                 265                 270         


Arg Asp Tyr Leu Leu Asn Lys Ala Pro Gln Asp Ile Asn Gln Arg Lys 
        275                 280                 285             


Leu Met Ala Ala Gln Glu Arg Leu Arg Gln Arg Leu Gln Lys Ala Ile 
    290                 295                 300                 


Arg Arg Arg Asn Gly Tyr Glu Glu Asp Arg Lys Lys Ile Gly Thr Lys 
305                 310                 315                 320 


Thr Asn Asn Phe Gly Lys Ala Ser Phe Val Asp Val Arg His Gly Ser 
                325                 330                 335     


Leu Ala Arg Tyr Leu Ser Glu Ser Phe Leu Glu Trp Gln Pro Thr Leu 
            340                 345                 350         


Glu Asn Gly Lys Gly Lys Leu Thr Gly Met Asn Phe Ser Lys Leu Gln 
        355                 360                 365             


Ala Glu Leu Ala Thr Phe Val Ser Pro Asp Gln Phe Asp Asp Ile Arg 
    370                 375                 380                 


Gln Met Leu Glu Glu Ala His Leu Leu Thr Gly Ser Ile Ala His Pro 
385                 390                 395                 400 


Phe Leu Lys Asn Ile Met Gly Lys Asn Val Gln Asn Ile Glu His Phe 
                405                 410                 415     


Tyr Leu Leu Tyr Leu Asn Glu Glu Ile Lys His Leu Arg Lys Ile Phe 
            420                 425                 430         


Asp Val Asp Glu Lys Ile Ala Asp Lys Asp Ile Asn Phe Asp Gly Leu 
        435                 440                 445             


Ile Leu Lys Asp Pro Asp Tyr Ser Lys Leu Pro Phe Ile Lys Gly Lys 
    450                 455                 460                 


Ala Arg Trp Glu Glu Arg Thr Pro Asp Tyr Tyr Arg Lys Leu Ala Gln 
465                 470                 475                 480 


Arg Tyr Leu Glu Val Asp Gly Lys Arg Ala Ala Val Cys Leu Pro Asp 
                485                 490                 495     


Gly Met Phe Ala Asp Gly Ile Leu Lys Met Leu Lys Thr Asn Tyr Ala 
            500                 505                 510         


Gly Asn Glu Val Leu Gln Ala His Leu Val Asn Glu Glu Leu Thr His 
        515                 520                 525             


Asn Val Ser Tyr Leu Ile Arg Val Phe Phe Glu Asp Gln Leu Lys Asp 
    530                 535                 540                 


Gln Ser Gln Pro Phe Tyr Ala Ser Ala Phe Gln Ser Asp Ala Asn Glu 
545                 550                 555                 560 


Pro Glu Glu Pro Ser Lys Phe Ala His His Tyr Asp Leu Phe Asp Ile 
                565                 570                 575     


Leu Asn Gly Glu Lys Ala Gly Leu Ser Leu Val Pro Val Tyr Leu Ser 
            580                 585                 590         


Ala Thr Gln Ile Asn Thr Ile Phe Thr Trp Lys Glu Leu Tyr Glu Leu 
        595                 600                 605             


His Leu Thr Ile Leu Lys Lys Thr Thr His Lys Val Arg Lys Asn Gly 
    610                 615                 620                 


Arg Glu Glu Arg Glu Val Ser Tyr Glu Thr Val Glu Arg Asp Phe Leu 
625                 630                 635                 640 


Gly Ile Lys Asp Asp Ile Met Glu Asn Val Arg Asn Met Gln Lys Lys 
                645                 650                 655     


Asp Met Gly Asn His Ser Thr Leu Gln Glu Ala Lys Asp Ala Arg Met 
            660                 665                 670         


Arg Lys Leu Thr Lys Ala Val Arg Asp Val Lys Asn Asn Glu Arg Ala 
        675                 680                 685             


Ile Arg Arg His Lys Thr Gln Asp Met Ile Leu Phe Leu Met Ala Glu 
    690                 695                 700                 


Gln Leu Leu Lys Asp Val Leu Ala Met Pro Asp Asn Gly Ala Asp Gly 
705                 710                 715                 720 


Lys Phe Lys Leu Arg Asn Val Cys Lys Gln Arg Phe Leu Ala Asn Thr 
                725                 730                 735     


Ile Asp Val Lys Phe Pro Phe Pro Val Glu Gly Glu Asn Val Phe Ile 
            740                 745                 750         


Thr Gln Gln Asn Val Ala Leu Lys Asn Tyr Gly Glu Phe Tyr Gln Leu 
        755                 760                 765             


Leu Ser Asp Asp Arg Leu Pro Ser Leu Leu Ala Lys Leu Val Gln Ser 
    770                 775                 780                 


Lys Lys Tyr Asp Lys Gly Glu Glu Ile Leu Ile Asp Tyr Ser Ser Leu 
785                 790                 795                 800 


Met Gly Glu Leu Thr Ser Tyr Asn Ile His Arg Ser Arg Ile Phe Trp 
                805                 810                 815     


Ala Ile His Gln Leu Glu Arg Phe Ile Val Thr Asn Gln Asn Phe Ala 
            820                 825                 830         


Glu Phe Leu Ser Asn Pro Ser Asp Met Arg Phe Phe Val His Glu Asp 
        835                 840                 845             


Arg Gly Ser Gly Pro Lys Arg Asn Asn Phe Arg Ser Leu Leu Glu Leu 
    850                 855                 860                 


Leu Glu Glu Thr Asp Ile Lys Val Leu Thr Pro Ala Glu Arg Glu Leu 
865                 870                 875                 880 


Ile Ile Ala Ile Arg Asn Ala Phe Ser His Asn His Tyr Gly Ile Asp 
                885                 890                 895     


Phe Ser Glu Leu Asp Leu Asp Asp Thr Thr Leu Leu His His Ala Asp 
            900                 905                 910         


Gly Ala Glu Ala Glu Asn Gly Lys Lys Lys Leu Thr Thr Ile Ala Thr 
        915                 920                 925             


Leu Ile Val Gly Lys Leu Leu Glu Leu Gln Glu Lys Val Lys Val His 
    930                 935                 940                 


Asn Gln 
945     


<210>  2276
<211>  1327
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2276

Met Gly Lys Asp Asn Lys Lys Tyr Gln Ala Lys Gly Gln Asp Gln Lys 
1               5                   10                  15      


Pro Arg Gln Thr Lys Lys Val Arg Arg Ile Gln Ser Lys Asp Phe Arg 
            20                  25                  30          


Ile Ser Leu Thr Gly Lys His Val Phe Gly Ala Tyr Phe Asn Met Ala 
        35                  40                  45              


Arg Thr Asn Phe Val Lys Thr Ile Asn Tyr Val Leu Pro Ile Ala Gly 
    50                  55                  60                  


Val Arg Gly Asn Tyr Ser Glu Asn Gln Ile Asn Lys Met Leu Gln Ala 
65                  70                  75                  80  


Leu Phe Leu Ile Gln Ser Asn Arg Asn Ala Glu Leu Thr Gln Glu Gln 
                85                  90                  95      


Gln Gln Trp Lys Lys Lys Leu Thr Leu Thr Ser Glu Gln Gln Thr Arg 
            100                 105                 110         


Leu Gln Arg Leu Leu Phe Lys His Phe Pro Val Leu Gly Pro Met Met 
        115                 120                 125             


Ala Glu Val Ala Asp His Lys Ala Tyr Leu Asn Lys Lys Lys Ser Lys 
    130                 135                 140                 


Val Gln Thr Glu Asp Glu Ala Phe Glu Gln Leu Arg Gly Val Ser Leu 
145                 150                 155                 160 


Ala Asp Cys Leu Glu Met Leu Val Leu Met Gly Met Thr Leu Thr Glu 
                165                 170                 175     


Cys Arg Asn Phe Tyr Thr His Arg Arg Pro Tyr Asn Ser Pro Ser Glu 
            180                 185                 190         


Leu Ala Gly Gln Tyr Ser His Gln Ala Thr Ile Ala Lys Lys Leu Asp 
        195                 200                 205             


Lys Val Val Val Ala Ser Arg Arg Ile Leu Lys Asp Arg Glu Gly Leu 
    210                 215                 220                 


Ser Val Asn Glu Ile Glu Phe Leu Thr Gly Ile Asp His Met Glu Gln 
225                 230                 235                 240 


Val Asp Val Leu Asp Glu Asn Gly Lys Pro Lys Met Val Asn Gly Lys 
                245                 250                 255     


Lys Met Lys Ser Phe Lys Glu Tyr Asp Asp Phe Tyr Phe Thr Leu Trp 
            260                 265                 270         


Ala Lys Arg Glu Ile Lys Asn Ile Thr Met Thr Gly Ser Asp Gly His 
        275                 280                 285             


Pro Thr Thr Ile Asp Thr Lys Leu Pro Ala Leu Ser Asp Phe Gly Leu 
    290                 295                 300                 


Leu Tyr Phe Cys Val Leu Phe Leu Ser Lys Pro Tyr Ala Lys Leu Phe 
305                 310                 315                 320 


Met Asp Glu Ala Arg Leu Phe Glu Phe Ser Pro Phe Thr Gly Gln Glu 
                325                 330                 335     


Asn Ile Ile Met Gln Glu Met Leu Cys Ile Tyr Arg Ile Arg Thr Pro 
            340                 345                 350         


Gln Leu His Arg Ile Asp Ser Arg Asp Ser Lys Ala Thr Leu Ala Met 
        355                 360                 365             


Asp Ile Phe Gly Glu Leu Arg Arg Cys Pro Thr Glu Leu Tyr Asp Leu 
    370                 375                 380                 


Leu Asp Lys Thr Ala Gly Gln Pro Phe Phe His Asp Val Val Lys Arg 
385                 390                 395                 400 


Pro Asn Ala Phe Thr Pro Glu Val Ser Lys Arg Leu Arg Tyr Thr Asp 
                405                 410                 415     


Arg Phe Pro His Leu Ala Leu Arg Tyr Ile Asp Gln Asn Asp Leu Phe 
            420                 425                 430         


Lys Arg Ile Arg Phe Gln Leu Gln Leu Gly Ala Phe Arg Tyr Lys Phe 
        435                 440                 445             


Tyr Asp Lys Thr Asp Cys Val Asp Gly Arg Val Arg Val Arg Arg Ile 
    450                 455                 460                 


Gln Lys Asp Ile Asn Gly Tyr Gly Arg Pro Gln Glu Val Asn Glu Lys 
465                 470                 475                 480 


Arg Phe Lys Thr Trp Glu Gly Leu Ile Gln Lys Arg Glu Glu Arg Ser 
                485                 490                 495     


Val Lys Leu Glu His Glu Glu Leu Tyr Ile Asp Leu Asp Gln Phe Leu 
            500                 505                 510         


Gln Asp Thr Ala Ala Ser Thr Pro Tyr Val Thr Asp Arg Arg Pro Ser 
        515                 520                 525             


Tyr Asn Ile His Ala Asn Arg Ile Gly Met Tyr Trp Glu Glu Ser Gln 
    530                 535                 540                 


Asn Pro Asn Gln Phe Lys Tyr Phe Asp Glu Lys Lys Ile Tyr Ile Pro 
545                 550                 555                 560 


Glu Leu Lys Val Thr Glu Asp Gly Lys Ala Pro Ile Glu Met Pro Val 
                565                 570                 575     


Pro Arg Cys Ser Leu Ser Val Tyr Asp Leu Ala Gly Met Leu Phe Tyr 
            580                 585                 590         


Glu Tyr Leu Leu Lys Arg Ser Asp Ser Lys Tyr Pro Ser Ala Glu Gln 
        595                 600                 605             


Ile Ile Ile Asp Cys Glu Ser Asp Tyr His Arg Phe Phe Ser Ala Val 
    610                 615                 620                 


Ala Asp Gly Thr Leu Lys Pro Phe Ala Lys Gln Lys Glu Leu Cys Asp 
625                 630                 635                 640 


Tyr Leu Ala Thr Asn Tyr Pro Asn Leu Arg Leu Ala Asp Ile Pro Glu 
                645                 650                 655     


Lys Leu Leu Leu Phe Leu Ser Gly Lys Gly Leu Thr His Asn Asn Met 
            660                 665                 670         


Pro Glu Thr Ala Arg Gln Arg Leu Val Arg Leu Thr Ile Glu His Leu 
        675                 680                 685             


Glu Glu Arg Glu Gln Arg Val Gln Arg Arg Leu Asp His Tyr Glu Glu 
    690                 695                 700                 


Asp Arg Lys Lys Ile Gly Asp Lys Glu Asn Lys Tyr Gly Lys Lys Gly 
705                 710                 715                 720 


Phe Ala Asp Val Arg His Gly Ala Leu Ala Arg Tyr Leu Ala Gln Ser 
                725                 730                 735     


Met Met Glu Trp Gln Pro Thr Lys Asp Gly Met Gly His Asp Lys Leu 
            740                 745                 750         


Thr Gly Leu Asn Tyr Asn Val Leu Thr Ala Tyr Leu Ala Thr Phe Gly 
        755                 760                 765             


Ala Pro Gln Pro Ala Asp Glu Pro Asp Phe Ala Pro Leu Ser Leu Gln 
    770                 775                 780                 


Glu Val Leu Ala Lys Ala His Leu Ile Gly Gly Ser Asn Pro His Pro 
785                 790                 795                 800 


Phe Leu Pro Lys Val Leu Ser His Thr Ile Thr Val Asn Arg Gln Thr 
                805                 810                 815     


Asp Arg Lys Met Thr Val Glu Pro Arg Asn Ile Glu Glu Phe Tyr Leu 
            820                 825                 830         


Phe Tyr Leu Glu Glu Glu Leu Lys His Ile Arg Ser Arg Met Gln Ser 
        835                 840                 845             


Leu Lys Thr Asn Ala Ser Asp Lys Ala Leu Ala Ser Leu Pro Phe Val 
    850                 855                 860                 


His His Asp Arg Met Arg Phe Arg Glu Arg Thr Ala Glu Glu Met Lys 
865                 870                 875                 880 


Ala Leu Ala Ser Arg Tyr Thr Thr Ile Gln Leu Pro Asp Gly Leu Phe 
                885                 890                 895     


Thr Pro His Ile Leu Lys Leu Leu Arg Ala Glu Tyr Ala Asp Asn Glu 
            900                 905                 910         


Ala Leu Gln Gln Ala Leu Asn Leu Gln Met Pro Asn Gln Leu Asn Pro 
        915                 920                 925             


Val Asn Asn Ala Ala Tyr Leu Ile Thr Leu Phe Tyr Gln Thr Val Leu 
    930                 935                 940                 


His Asp Asp Ala Gln Pro Phe Tyr Met Ser Ala Lys Ala Tyr Thr Arg 
945                 950                 955                 960 


Gln Asn Ala Asp Asn Lys Thr Glu Thr Phe Ser Phe Lys Arg Ala Tyr 
                965                 970                 975     


Glu Leu Phe Thr Ile Leu Ala Asp Asp Lys Glu Asn Phe Phe Pro Phe 
            980                 985                 990         


Glu Leu Lys Pro Leu Phe Leu Thr  Cys Asp Asp Ile Gln  Ala Arg Ile 
        995                 1000                 1005             


Ser Ala  Lys Val Lys Asp Glu  Thr Gly Asp Pro Ile  Ala Lys Ile 
    1010                 1015                 1020             


Gly Lys  Lys Glu Lys Asp Ser  Gln Gly Asn Ile Ile  Trp Leu Arg 
    1025                 1030                 1035             


Glu Ile  Thr Glu Lys Ile Asp  Val Tyr Val Asp Ser  Arg Thr Asp 
    1040                 1045                 1050             


Lys Asp  Leu Lys Ile Ser Ala  Asn Gln Ser Arg Lys  Glu Lys Glu 
    1055                 1060                 1065             


Ala Glu  Arg Glu Gln Lys Arg  Glu Ala Leu Arg Leu  Arg Leu Asn 
    1070                 1075                 1080             


Arg Met  Val Arg Glu Val Lys  Asp Asn Glu Arg Thr  Leu Arg Arg 
    1085                 1090                 1095             


Phe Lys  Thr Gln Asp Met Val  Leu Phe Leu Met Ala  Lys Asp Met 
    1100                 1105                 1110             


Phe Thr  Asn Ile Leu Ser Asp  Gln Glu Arg Glu Val  Asn Trp Lys 
    1115                 1120                 1125             


His Leu  Arg Leu Ser Lys Val  Cys Asn Glu Ala Phe  Leu Arg Gln 
    1130                 1135                 1140             


Thr Leu  Thr Phe Leu Ile Pro  Val Thr Ile Gly Asp  Val Thr Ile 
    1145                 1150                 1155             


Tyr Val  Glu Gln Glu Asn Met  Ser Leu Lys Asn Tyr  Gly Glu Phe 
    1160                 1165                 1170             


Tyr Arg  Phe Leu Thr Asp Asp  Arg Leu Thr Ser Leu  Leu Glu Asn 
    1175                 1180                 1185             


Ile Val  Gly Asp Leu Glu Pro  Asp Gln Gln Gly Arg  Leu Val Ile 
    1190                 1195                 1200             


Arg His  Thr Asp Leu Met Ser  Glu Leu Ala Ala Tyr  Asp Gln Lys 
    1205                 1210                 1215             


Arg Ser  Thr Val Phe Lys Leu  Ile Gln Gln Ile Glu  Ala Leu Ile 
    1220                 1225                 1230             


Ile Lys  Ser Asn Asp Ala Leu  Ser Asn Pro Ala Ser  Pro Asp Phe 
    1235                 1240                 1245             


Trp Ala  Lys Pro Gly Leu Pro  Lys Arg Asn Asn Phe  Ala Ser Leu 
    1250                 1255                 1260             


Leu Glu  Leu Ile Asp His Leu  Asn Gln Thr Ala Leu  Thr Thr Glu 
    1265                 1270                 1275             


Glu Arg  Thr Leu Leu Val Ala  Ile Arg Asn Ala Phe  Ser His Asn 
    1280                 1285                 1290             


Ser Tyr  Asn Leu Asp Leu Thr  Gln Ile Ala Gly Val  Lys His Leu 
    1295                 1300                 1305             


Pro Glu  Val Ala Asn Ser Ile  Leu Lys His Leu Glu  Thr Ile Met 
    1310                 1315                 1320             


Gly Glu  Thr Gln 
    1325         


<210>  2277
<211>  1220
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2277

Met Ser Thr Arg Tyr Thr Asn Gln Lys Lys Val Glu Glu Asn Ile Asn 
1               5                   10                  15      


Tyr Val Phe Ser Asn Lys Gly Ile Phe Ala Ala Val Ala Glu Lys Thr 
            20                  25                  30          


Leu Thr Asn Tyr Lys Ser Lys Phe Asn Glu Gly Gln Thr Ile Gln Pro 
        35                  40                  45              


Asn Leu His Tyr Phe Ala Val Gly His Thr Phe Lys Asn Ile Asp Thr 
    50                  55                  60                  


Lys Arg Ile Phe Asp Tyr Gln Leu Ser Glu Asp Glu Met Asp Ile Leu 
65                  70                  75                  80  


Pro Thr Lys Tyr Phe Ser Leu Gln Gln Asn Lys Phe Ser Phe Pro Ile 
                85                  90                  95      


Asp Gly Gln Thr Lys Thr Asp Lys Leu Tyr Leu Leu Leu Asp Asn Ile 
            100                 105                 110         


Arg Asn Ile Asn Ala His Phe Ile His Asp Phe Asn Phe Leu Lys Val 
        115                 120                 125             


Asp Asn Ile Asp Glu Asn Ile Ile Cys Phe Leu Ile Asp Ser Phe Glu 
    130                 135                 140                 


Leu Ala Leu Ile Lys Gly Val Phe Ala Lys Lys Tyr Gly Asn Lys Lys 
145                 150                 155                 160 


His Glu Leu Gly Leu Asp Phe Leu Ser Asn Asp Leu Lys Asp Glu Ile 
                165                 170                 175     


Leu Glu Glu Ile Leu Glu Asn Leu Asp Asp Glu Leu Ile Val Phe Met 
            180                 185                 190         


Lys Glu Ile Phe Tyr Gln Thr Leu Tyr Val Val Asp Lys Lys Glu Trp 
        195                 200                 205             


Arg Asn Lys Glu Leu Asn Gln Glu Lys Lys Asp Phe Leu Asp Ser His 
    210                 215                 220                 


Leu Ser Ser Lys Glu Asp Trp Ile Asn Trp Ile Leu Phe Asn Cys Val 
225                 230                 235                 240 


Glu Glu Asp Ile Asp Trp Phe Leu Asn Asn Tyr Gly Asp Ser Asp Pro 
                245                 250                 255     


His Pro Asp Ser Lys Asn His Lys His Lys Val Leu Thr Ile Glu Lys 
            260                 265                 270         


Gly Lys His Leu Ser Phe Glu Gly Ser Leu Phe Met Met Thr Met Phe 
        275                 280                 285             


Leu Tyr Ala Asn Glu Ala Asn Tyr Leu Ile Pro Lys Leu Lys Gly Tyr 
    290                 295                 300                 


Lys Lys Asn Gly Thr Pro Gln Asp Ala Ser Lys Leu Glu Val Phe Arg 
305                 310                 315                 320 


Phe Phe Ala Lys Lys Phe Lys Ser Gln Asp Val Asp Ser Glu His Lys 
                325                 330                 335     


Gln Tyr Val Lys Phe Arg Asp Met Ile Gln Tyr Val Gly Lys Tyr Pro 
            340                 345                 350         


Thr Val Trp Asn Lys His Ile His Leu Asp Asn Tyr Tyr Val Asn Glu 
        355                 360                 365             


Leu Lys Val Ser Ile Leu Glu Asn Glu Ile Thr Gln Leu Phe Glu Gln 
    370                 375                 380                 


Asp Ile Gln Asn Tyr Phe Glu Thr Lys Tyr Gly Leu Gln Lys Phe Ala 
385                 390                 395                 400 


Lys Ala Lys Gly Asp Met His Tyr Ala Phe Val Glu Val Ala Lys Ser 
                405                 410                 415     


Tyr Leu Gln Lys Lys Thr Ile Ser Tyr Lys Gly Lys Tyr Gln Asp Asp 
            420                 425                 430         


Ser Ile Ala Ile Leu Glu Thr Leu Ala Glu Gln Ile Thr Asn Lys Arg 
        435                 440                 445             


Gln Leu Lys Asn Ile Glu Val Lys Leu Leu Arg Phe Ser Asp Thr Asp 
    450                 455                 460                 


Tyr Gln Ser Leu Ser Ser Ile Glu Lys Thr Lys Lys Gln Arg Leu Asp 
465                 470                 475                 480 


Lys Ser Lys Lys Met Phe Leu Asp Lys Ile Lys Glu Ser Lys Lys Thr 
                485                 490                 495     


Ile Asn Lys Thr Thr Glu Lys Phe Ala Lys Arg Val Glu Asp Asn Leu 
            500                 505                 510         


Leu Tyr Ile Ser Asn Gly Arg Asn Ser Asp Arg Phe Met Val Phe Ala 
        515                 520                 525             


Cys Arg Phe Leu Ala Glu Ile Asn Tyr Phe Gly Lys Asp Ala Gln Phe 
    530                 535                 540                 


Lys Met Tyr Glu Asn Tyr Tyr Ser Glu Glu Glu Gln Asn Ala Leu Lys 
545                 550                 555                 560 


Asp Lys Lys Gln Asn Leu Thr Gln Lys Asp Phe Asp Lys Leu His Tyr 
                565                 570                 575     


His Trp Gly Lys Leu Thr His Phe Glu Thr Phe Glu Asn His Val Lys 
            580                 585                 590         


Lys Tyr Pro Asn Trp Asp Met Pro Phe Val Val Gln Asn Asn Ala Ile 
        595                 600                 605             


Tyr Val Lys Ile Pro Gly Ile Asn Phe Ile Lys Asn Thr Ala Phe Cys 
    610                 615                 620                 


Ile Arg Arg Asn Val Ile Asn Tyr Leu Leu Glu His Ala Leu Gly Glu 
625                 630                 635                 640 


Asn Tyr Lys Asp Gln Gln Gly Arg Glu Trp Leu Phe Asp Tyr Tyr Glu 
                645                 650                 655     


Tyr Lys Thr Glu Ala Thr Asp Asn Ala Lys Arg Ile Leu Thr Glu Ser 
            660                 665                 670         


Lys Pro Ile Glu Ala Ser Ser Lys Thr Gln Leu Lys Lys Leu Leu Pro 
        675                 680                 685             


Lys Lys Leu Leu Pro Lys His Ser Pro Leu Glu Thr Glu Asn Lys Glu 
    690                 695                 700                 


Asn Ile Phe Arg Lys Tyr Leu Glu Gln Ala Glu Glu Ser Glu Lys Leu 
705                 710                 715                 720 


Tyr Glu Asn Gln Lys Asp Lys Ala Lys Ala Glu Lys Lys Leu Asp Leu 
                725                 730                 735     


Phe Val Asn Lys Asn Lys Gly Lys Gln Phe Lys Leu Arg Phe Ile Phe 
            740                 745                 750         


Lys Ala Trp Gln Leu Met Tyr Phe Lys Lys Gln Tyr Gln Ile Glu Lys 
        755                 760                 765             


Glu Arg Tyr Ala Glu Leu Glu Lys Leu Asp Gly Ile Pro Lys Asn Tyr 
    770                 775                 780                 


Glu His Glu Phe Gly His His Lys Lys Phe Asn Ile Asn Arg Lys Glu 
785                 790                 795                 800 


Phe Asn Leu Phe Ser Lys Trp Leu Phe Ala Met Asp Glu Val Pro Glu 
                805                 810                 815     


Tyr Lys Asn Ser Leu Lys Glu Leu Leu Asp Asp Lys Asn Phe Phe Val 
            820                 825                 830         


Asn Ser Glu Phe Gln Lys Leu Phe Glu Ser Ser Ser Asn Ile Asn Gln 
        835                 840                 845             


Phe Tyr Glu Ser Thr Lys Ser Lys Phe Lys Asn Trp Leu Asn Asp Gln 
    850                 855                 860                 


Gln Val Gln Asn Ile Arg Lys Thr Ile Gln Pro Glu Asn Tyr Tyr Lys 
865                 870                 875                 880 


Met Met Glu Val Gly Asn Phe His Ile Asn Leu Ser His Phe Ile Ala 
                885                 890                 895     


Phe Gly Val Ser His Asp Phe Ile Glu Lys Ser Gly Lys Asn Ile Leu 
            900                 905                 910         


Arg Pro Ile Thr Ser His Ala Lys Tyr Leu Asn Thr Lys Ile Tyr Asp 
        915                 920                 925             


Ile Asp Leu Glu His Ser Asp Ala Ser Asn Leu Glu Lys Asn Ile Phe 
    930                 935                 940                 


Arg Lys Leu Tyr Lys Ile Arg Leu Glu Asp Cys Leu Leu Tyr Glu Ile 
945                 950                 955                 960 


Ala Leu Arg Tyr Phe Gln Pro Asn Leu Asn Leu Arg Gln Lys Ser Tyr 
                965                 970                 975     


Glu Gln Leu Asn Lys Leu Leu Val Gln Lys Ile Ser Ile Ala Ile Lys 
            980                 985                 990         


Ala Asn Asn Ser Gln Thr Tyr Gln  Val Leu Val Pro Phe  Lys Asp Leu 
        995                 1000                 1005             


Glu Lys  Phe Ala Gln Leu Lys  Ala Ile Asp Asp Asn  Thr Gln Asn 
    1010                 1015                 1020             


Lys Phe  Ser Leu Leu Arg Arg  Leu Pro Glu Tyr Leu  Ser Gln Val 
    1025                 1030                 1035             


Asn Glu  Arg Asn Glu Asn Val  Ser Gly Leu Lys Asp  Met Val Glu 
    1040                 1045                 1050             


Ala Phe  Gly Val Asp Lys Ser  Ile Ser Leu Ala Asp  Met Ser Met 
    1055                 1060                 1065             


Leu Tyr  Asn His Leu Ile Thr  Gln Gln Gly Arg Tyr  Thr Asn Cys 
    1070                 1075                 1080             


Ile Met  Ala Leu Glu Glu Tyr  Phe Ile Trp Lys Glu  Lys Phe Thr 
    1085                 1090                 1095             


Ile Glu  Lys Gln Glu Ser Lys  Lys Phe Lys Asn Arg  Ile Val Val 
    1100                 1105                 1110             


Thr Glu  Ile Pro Val Leu Lys  Asp Tyr Phe Lys Arg  Asp Glu Gln 
    1115                 1120                 1125             


Arg Asn  Asn Ala Phe His Met  Asp Leu Pro Ile Asn  Glu Thr Tyr 
    1130                 1135                 1140             


Lys Ser  Thr Phe Lys Ala Ile  Glu Lys Gln Phe Val  Ala Thr Glu 
    1145                 1150                 1155             


Val Asp  Lys Ala Tyr Thr Lys  Leu Asp Asp Cys Pro  Ser Met Leu 
    1160                 1165                 1170             


Lys Asn  Thr Leu Lys Val Phe  Met Asn Gln Met His  Asp Glu Ile 
    1175                 1180                 1185             


Lys Leu  Gly Tyr Lys Pro Asn  Asp Thr Lys Asp Gly  Ile Lys Gln 
    1190                 1195                 1200             


Lys Arg  Thr Val Ala Glu Asn  Thr Phe Phe Lys Gln  Leu Leu Lys 
    1205                 1210                 1215             


Gly Tyr  
    1220 


<210>  2278
<211>  1128
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2278

Met Glu Asn Lys Arg Thr Leu Lys Asp His Pro Gln Tyr Phe Gly Ala 
1               5                   10                  15      


Phe Leu Asn Met Ala Arg His Asn Val Phe Val Ile Asn Asn His Leu 
            20                  25                  30          


Ala Glu Arg Phe Lys Leu Ser Pro Leu Pro Glu Asp Ser His Ile Pro 
        35                  40                  45              


Thr Ser Phe Leu Thr Arg Pro Ile Lys Glu Arg Pro Asn His Ile Phe 
    50                  55                  60                  


Ser His Leu Ile Arg Phe Ile Pro Ile Ala Lys Val Phe Asp Pro Glu 
65                  70                  75                  80  


Gln Leu Pro Lys Glu Glu Arg Thr Glu Glu Lys Ser Lys Thr Gly Lys 
                85                  90                  95      


Asp Phe Asn Lys Leu Lys Glu Thr Phe Lys Ile Cys Phe Ser Glu Leu 
            100                 105                 110         


Asn Asp Phe Arg Asn Asp Tyr Ser His Phe Phe Ser Thr Lys Lys Arg 
        115                 120                 125             


Thr Glu Arg Lys Leu Met Val Asp Lys Leu Leu Ala Asp Phe Leu Thr 
    130                 135                 140                 


Thr Asn Tyr Ser Arg Ala Ile Gln Tyr Ser Ile Lys Arg Phe Thr Gly 
145                 150                 155                 160 


Val Phe Lys Asp Glu His Phe Glu Leu Ala Arg Lys Asn Ile Ile Leu 
                165                 170                 175     


Val Asp Asn Glu Asn Lys Ile Thr Glu Asp Gly Leu Val Phe Phe Thr 
            180                 185                 190         


Cys Leu Phe Leu Asp Arg Glu Asn Ala Phe Gln Phe Ile Asn Lys Ile 
        195                 200                 205             


Ile Gly Phe Lys Gly Thr His Thr Leu Glu Phe Lys Ala Thr Arg Glu 
    210                 215                 220                 


Val Phe Cys Ala Phe Cys Val Asn Leu Pro His Asp Arg Phe Ile Ser 
225                 230                 235                 240 


Asp Asp Pro Glu Gln Ala Phe Ile Leu Asp Met Leu Asn Glu Leu Asn 
                245                 250                 255     


Arg Cys Pro Ser Glu Leu Phe Asn Ser Leu Thr Glu Glu Gly Lys Lys 
            260                 265                 270         


Pro Phe Gln Pro Thr Leu Asp Ser Lys Gln Ile Thr Asn Ile Glu Asp 
        275                 280                 285             


Asn Asn Ala Val Ala Lys Glu Leu Pro Asp Glu Asp Phe Tyr Glu Tyr 
    290                 295                 300                 


Met Gln Ser Ile Thr Lys Arg Ile Arg His Glu Asp Arg Phe Pro Tyr 
305                 310                 315                 320 


Leu Ala Leu Lys Tyr Leu Asp Thr Thr Lys Ala Phe Asn Lys Ile Arg 
                325                 330                 335     


Phe Gln Ile Asp Leu Gly Lys Phe Gln Ile Asp Glu Tyr Lys Lys Gln 
            340                 345                 350         


Phe Asn Asn Ala Glu Glu Asp Arg Met Ile Ile Glu Asn Ala Lys Ala 
        355                 360                 365             


Phe Gly Arg Leu Asp Glu Phe Thr Ser Ile Glu Lys Thr Lys Asp Glu 
    370                 375                 380                 


Leu Glu Lys Val Ile Gly Lys Met Ile Asn Lys Asp Gly Phe Lys Asn 
385                 390                 395                 400 


Val Asp Ser Lys Gln Phe Ala Phe Glu Gln Phe Ser Pro Arg Tyr Asn 
                405                 410                 415     


Tyr Asp Lys Glu Lys Asn Lys Ile Gly Phe Gln Phe Phe Pro Asn Gly 
            420                 425                 430         


Ile Gly Val Pro Ile Tyr Pro Lys Leu Lys Lys Ser Glu Asn Glu Lys 
        435                 440                 445             


Ser Asn Val Lys Tyr Asn Leu Phe Gln Asn Asn Pro His Ala Phe Leu 
    450                 455                 460                 


Ser Ile His Glu Leu Pro Lys Val Val Leu Leu Glu Leu Leu Glu Lys 
465                 470                 475                 480 


Gly Lys Val Glu Thr Ile Ile Glu Glu Phe Ile Asn Ser Asn Asn Thr 
                485                 490                 495     


Lys Ile Leu Asn Lys Asp Phe Ile Glu Glu Ile Lys Asn Lys Leu Lys 
            500                 505                 510         


Phe Glu Lys Pro Phe Tyr Lys Lys Phe Gln Lys Lys Asn Leu His Ala 
        515                 520                 525             


Tyr Asp Asn Pro Ser Ile Glu Asp Tyr Thr Glu Arg Lys Asn Lys Leu 
    530                 535                 540                 


Asn Glu Ile Leu Asn Asp Leu Lys Thr Arg Lys Glu Gln Leu Asn Glu 
545                 550                 555                 560 


Leu Leu Ser His Tyr Asn Leu Asn His Thr Gln Ile Pro Thr Arg Ile 
                565                 570                 575     


Val Asn Tyr Trp Leu Asp Ile Lys Glu Val Gly Lys Glu Thr Ala Ile 
            580                 585                 590         


Ala Asn Arg Ile Lys Ala Phe Arg Ser Glu Cys Ala Glu Arg Leu Lys 
        595                 600                 605             


Asp Asn Lys Lys Gly Lys Ala Pro Lys Ile Gly Val Met Ala Thr Phe 
    610                 615                 620                 


Leu Ala Lys Asp Ile Val Asn Met Val Ile Asp Glu Asn Ile Lys Lys 
625                 630                 635                 640 


Lys Ile Thr Pro Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu 
                645                 650                 655     


Phe Ala Gly Asp Glu Asn Lys Gln Leu Phe Ile Thr Ile Cys Asn Glu 
            660                 665                 670         


Leu Asn Leu Phe Asn Lys Glu Thr Gly His Pro Phe Leu Lys Asp Ile 
        675                 680                 685             


Arg Ile Asn Glu Ile His Tyr Thr Ser Asp Phe Tyr Gln Met Tyr Leu 
    690                 695                 700                 


Glu Lys Lys Gln Asn Trp Ile Val Asn Val Phe Tyr Lys Leu Glu Trp 
705                 710                 715                 720 


Asn Glu Lys Ala Lys Lys Lys Leu Thr Thr Val Ala Leu Pro Glu Asn 
                725                 730                 735     


Leu Thr Leu Pro Phe Ser Ile Arg Asn Leu Asp Arg Thr Lys Ser Asp 
            740                 745                 750         


Phe Asp Ser Trp Leu Asn Asn Leu Ile Asn Gly Lys Lys Glu Lys Asp 
        755                 760                 765             


Asn Pro Lys Pro Leu Asp Leu Pro Thr Asp Leu Phe Asp Asn Ala Leu 
    770                 775                 780                 


Val Glu Val Leu Thr Asn Lys Ile Gly Ile Glu Arg Asn Pro Lys His 
785                 790                 795                 800 


Asn Tyr Ser Tyr Leu Leu Thr Gln Trp Leu Lys Asp Thr Gln Pro Phe 
                805                 810                 815     


Tyr Asn Phe Glu Arg Glu Tyr Glu Ile Tyr Lys Asp Lys Val Tyr Lys 
            820                 825                 830         


Glu Thr Val Lys Phe Lys Leu Gly Ser Lys Pro Thr Phe Lys Asp Tyr 
        835                 840                 845             


Phe Leu Ser Ser Ile Lys Thr Val Leu Gln Lys Leu Asn Ile Glu Arg 
    850                 855                 860                 


Lys Ile Glu Arg Lys Pro Leu Leu Asn Glu Asn Asp Val Leu Arg Val 
865                 870                 875                 880 


Phe Asn His Ala Ile Thr Glu Asn Glu Lys Leu Ile Arg Phe Tyr Gln 
                885                 890                 895     


Thr Lys Asp Arg Val Met Leu Leu Met Leu Lys Glu Leu Met Lys Ser 
            900                 905                 910         


Asp Arg Asp Leu Asn Ile Thr Leu His Asn Ile Glu Ala Ala Leu Asn 
        915                 920                 925             


Glu Thr Val Glu Ile Glu Gln Lys Val Lys Gly Phe Leu Ser Tyr Asp 
    930                 935                 940                 


Ala Glu Gly Asn Tyr Ile Asp Lys Gln Asn Asp Arg Thr Glu Glu Ile 
945                 950                 955                 960 


Asn Lys Thr Ile Thr Asp Lys Arg Lys Arg Lys Asp Phe Ser Val Phe 
                965                 970                 975     


Lys Lys Phe Ile Ser Asp Arg Arg Leu Pro Glu Leu Phe Gln Tyr Phe 
            980                 985                 990         


Lys Glu Asn Glu Ile Pro Tyr Gln  Gln Leu Lys Asp Glu  Leu Asp Glu 
        995                 1000                 1005             


Tyr Asn  Lys Glu Lys Glu Lys  Val Phe Asp Glu Thr  Phe Lys Leu 
    1010                 1015                 1020             


Glu Thr  Ala Ile Ile Glu Lys  Ala Glu Asn Glu Ile  Lys Glu Leu 
    1025                 1030                 1035             


Phe Arg  Asp Lys Lys Gly Asn  Lys Ile Glu Gly Asn  Ile Gln Phe 
    1040                 1045                 1050             


Glu Pro  Tyr Leu Lys Trp Leu  Lys Glu Lys Asn Phe  Ile Gly Asp 
    1055                 1060                 1065             


Thr Glu  Phe Lys Ile Leu Lys  Val Ile Arg Asn Ala  Phe Ser His 
    1070                 1075                 1080             


Asn Gln  Phe Pro Pro Lys Ile  Val Met Asp Lys Asn  Ile Gln Trp 
    1085                 1090                 1095             


Gln Gln  Asn Ile Ser Ile Ser  Gln Gln Ile Tyr Glu  Thr Tyr Ala 
    1100                 1105                 1110             


Ser Thr  Ile Ala Thr Val Leu  Asp Lys Ile Ala Thr  Leu Ile Leu 
    1115                 1120                 1125             


<210>  2279
<211>  1097
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2279

Met Glu Asn Asp Lys Lys Leu Glu Glu Ser Ala Cys Tyr Thr Leu Asn 
1               5                   10                  15      


Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val 
            20                  25                  30          


Tyr Ile Thr Val Asn His Ile Asn Lys Thr Leu Gly Glu Gly Glu Ile 
        35                  40                  45              


Asn Arg Asp Gly Tyr Glu Thr Thr Leu Glu Asn Thr Trp Asn Glu Ile 
    50                  55                  60                  


Lys Asp Ile Asn Lys Lys Ala Arg Leu Arg Glu Leu Ile Ile Lys His 
65                  70                  75                  80  


Phe Pro Phe Leu Glu Ala Ala Thr Tyr Gln Gln Arg Ser Thr Asp Ser 
                85                  90                  95      


Thr Lys Gln Lys Glu Glu Lys Gln Ala Glu Ala Gln Ser Leu Glu Ser 
            100                 105                 110         


Leu Lys His Cys Leu Phe Pro Phe Leu Lys Lys Leu Gln Lys Ser Arg 
        115                 120                 125             


Asp His Tyr Ser His Tyr Lys His Ser Lys Ser Leu Glu Arg Pro Lys 
    130                 135                 140                 


Phe Glu Glu Asp Leu Gln Lys Lys Met Tyr Asn Ile Phe Asp Val Ser 
145                 150                 155                 160 


Ile Arg Leu Val Lys Glu Asp Tyr Lys His Asn Thr Asp Ile Asn Leu 
                165                 170                 175     


Lys Glu Asp Phe Lys His Leu Asn Arg Thr Gly Lys Phe Lys Tyr Ser 
            180                 185                 190         


Phe Ala Asp Asn Lys Gly Asn Ile Thr Glu Ser Gly Leu Leu Phe Phe 
        195                 200                 205             


Ile Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Met Gln Lys Lys 
    210                 215                 220                 


Leu Lys Gly Phe Lys Asp Ser Arg Glu Lys Tyr Gln Lys Met Thr Asn 
225                 230                 235                 240 


Glu Val Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu Glu 
                245                 250                 255     


Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu Asn Glu Leu 
            260                 265                 270         


Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Arg Glu Lys Glu Arg 
        275                 280                 285             


Lys Glu Phe Lys Val Pro Ile Glu Ile Ala Asp Glu Asp Tyr Asp Ala 
    290                 295                 300                 


Glu Gln Glu Pro Phe Arg Asn Thr Leu Val Arg His Gln Asp Arg Phe 
305                 310                 315                 320 


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Tyr Asn Glu Ile Phe Thr Asn 
                325                 330                 335     


Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile Tyr Lys 
            340                 345                 350         


Lys Leu Ile Gly Gly Asn Lys Glu Asp Arg His Leu Thr His Lys Leu 
        355                 360                 365             


Tyr Gly Phe Glu Arg Ile Gln Glu Phe Ala Lys Gln Asn Arg Pro Asp 
    370                 375                 380                 


Glu Trp Lys Ala Leu Val Lys Asp Leu Asp Thr Phe Asn Lys Glu Glu 
385                 390                 395                 400 


Glu Lys Pro Tyr Ile Ser Glu Thr Thr Pro His Tyr His Leu Glu Asn 
                405                 410                 415     


Glu Lys Ile Gly Ile Val Phe Lys Asn His Asn Ile Trp Pro Ser Thr 
            420                 425                 430         


Gln Thr Glu Leu Thr Asn Asn Asn Arg Lys Lys Tyr Asn Leu Gly Val 
        435                 440                 445             


Ser Ile Lys Ala Glu Ala Phe Leu Ser Val His Glu Leu Leu Pro Met 
    450                 455                 460                 


Met Phe Tyr Tyr Leu Leu Leu Lys Thr Lys Asn Thr His Asn Gly Asn 
465                 470                 475                 480 


Glu Val Glu Ala Lys Lys Lys Gly Thr Lys Asn Lys Lys Gln Glu Lys 
                485                 490                 495     


His Lys Ile Glu Ala Ile Ile Glu Ser Lys Ile Lys Asp Ile Tyr Asn 
            500                 505                 510         


Leu Tyr Asp Ala Phe Ala Asn Gly Glu Ile Asn Ser Ile Glu Glu Leu 
        515                 520                 525             


Glu Glu His Cys Lys Gly Lys Asp Ile Glu Ile Gly His Leu Pro Lys 
    530                 535                 540                 


Gln Met Ile Ala Ile Leu Lys Asp Glu His Lys Asp Met Ala Lys Lys 
545                 550                 555                 560 


Ala Glu Thr Lys Gln Glu Lys Met Ile Leu Ala Thr Glu Asn Arg Leu 
                565                 570                 575     


Lys Thr Leu Asp Lys Lys Leu Lys Gly Lys Ile Arg Asn Gly Lys Arg 
            580                 585                 590         


Cys Asn Ser Ala Leu Lys Ser Gly Glu Ile Ala Ser Trp Leu Val Asn 
        595                 600                 605             


Asp Met Met Arg Phe Gln Pro Val Gln Arg Asp Glu Glu Gly Lys Pro 
    610                 615                 620                 


Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln Leu Leu Gln Arg 
625                 630                 635                 640 


Thr Leu Ala Phe Phe Gly Ser Glu His Glu Arg Leu Asp Pro Tyr Phe 
                645                 650                 655     


Lys Gln Met Asn Leu Ile Gly Asp Asn Asn Pro His Pro Phe Leu Lys 
            660                 665                 670         


Glu Thr Lys Trp Glu Glu Cys Asn Asn Ile Leu Ser Phe Tyr Arg Ser 
        675                 680                 685             


Tyr Leu Glu Ala Lys Lys Asn Phe Leu Glu Ser Leu Lys Pro Glu Asp 
    690                 695                 700                 


Trp Lys Lys Asn Gln Tyr Phe Leu Met Leu Lys Glu Pro Lys Asn Asn 
705                 710                 715                 720 


Arg Glu Thr Leu Val Gln Gly Trp Lys Asn Gly Phe Asn Leu Pro Arg 
                725                 730                 735     


Gly Ile Phe Thr Glu Pro Ile Arg Lys Trp Phe Met Glu His Arg Lys 
            740                 745                 750         


Lys Ile Lys Ala Asp Glu Leu Lys Arg Val Gly Phe Val Ala Lys Ala 
        755                 760                 765             


Ile Pro Leu Phe Phe Ser Lys Glu Tyr Lys Asp Gly Val Gln Pro Phe 
    770                 775                 780                 


Tyr Asn Tyr Pro Phe Asn Val Gly Asn Ile Asn Lys Pro Glu Glu Lys 
785                 790                 795                 800 


Asp Phe Leu Asp Tyr Glu Lys Arg Lys Lys Leu Trp Asp Lys Lys Gln 
                805                 810                 815     


Ala Lys Phe Lys Gly Lys Thr Asp Lys Glu Lys Arg Glu Asp Pro Ser 
            820                 825                 830         


Tyr Pro Asp Phe Lys Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu 
        835                 840                 845             


Val Arg Asn Gln Asp Ile Val Thr Trp Met Leu Cys Met Glu Leu Phe 
    850                 855                 860                 


Glu Glu Gln Lys Val Asp Gly Leu Asn Thr Gly Gln Ile His Leu Lys 
865                 870                 875                 880 


Asp Ile Val Thr Asn Val Asp Glu Glu Gly Asn Asn Asn Ile Leu Asn 
                885                 890                 895     


Gln Ile Lys Pro Met Gln Leu Pro Ile Thr Val Tyr Asp Lys Glu Asn 
            900                 905                 910         


Ser Pro Lys Arg Lys Pro Leu His Thr Val Tyr Ile Glu Glu Thr Gly 
        915                 920                 925             


Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys Asp Arg 
    930                 935                 940                 


Arg Leu Asn Gly Leu Phe Ser Phe Val Lys Thr Ser Ser Glu Ala Glu 
945                 950                 955                 960 


Ser Lys Ser Lys Pro Ile Ser Lys Ser Arg Val Glu Tyr Glu Leu Gly 
                965                 970                 975     


Ala Tyr Gln Lys Ala Arg Ile Asp Ile Ile Lys Asp Met Leu Ala Leu 
            980                 985                 990         


Glu Lys Thr Leu Ile Asp Asn Asp  Glu Asn Leu Pro Thr  Asn Lys Phe 
        995                 1000                 1005             


Ser Asp  Met Leu Lys Ser Trp  Leu Lys Gly Lys Gly  Glu Ala Asn 
    1010                 1015                 1020             


Lys Ala  Arg Phe Gln Asn Asp  Val Lys Phe Leu Ile  Ala Val Arg 
    1025                 1030                 1035             


Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met Tyr Asp  Glu Lys Leu 
    1040                 1045                 1050             


Phe Val  Asn Ile Glu Pro Phe  Ser Leu Ser Ser Ser  Asp Ile Leu 
    1055                 1060                 1065             


Glu Lys  Glu Gly Leu Arg Ile  Ala Val Gln Leu Glu  Glu Glu Val 
    1070                 1075                 1080             


Arg Lys  Ala Val Glu Lys Ile  Lys Lys Ser Glu Thr  Lys Lys 
    1085                 1090                 1095         


<210>  2280
<211>  1122
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2280

Met Lys Glu Glu Glu Glu Lys Gly Lys Thr Pro Val Val Ser Thr Tyr 
1               5                   10                  15      


Asn Lys Asp Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg 
            20                  25                  30          


His Asn Val Tyr Ile Thr Ile Asn His Ile Asn Lys Leu Leu Glu Ile 
        35                  40                  45              


Arg Glu Ile Asp Asn Asp Glu Lys Ile Leu Asp Ile Lys Asp Leu Trp 
    50                  55                  60                  


Gln Lys Val Asn Lys Asn Leu Asn Gln Lys Ala Arg Leu Arg Glu Leu 
65                  70                  75                  80  


Met Thr Lys His Phe Pro Phe Leu Glu Thr Ala Ile Tyr Ser Lys Asn 
                85                  90                  95      


Lys Glu Asp Lys Glu Glu Val Lys Gln Glu Lys Gln Ala Lys Ala Gln 
            100                 105                 110         


Ser Phe Asp Ser Leu Lys His Cys Leu Phe Leu Phe Leu Glu Lys Leu 
        115                 120                 125             


Gln Glu Ala Arg Asn Tyr Tyr Ser His Tyr Lys Tyr Ser Glu Ser Thr 
    130                 135                 140                 


Lys Glu Pro Met Leu Glu Lys Glu Leu Leu Lys Lys Met Tyr Asn Ile 
145                 150                 155                 160 


Phe Asp Asp Asn Ile Gln Leu Val Ile Lys Asp Tyr Gln His Asn Lys 
                165                 170                 175     


Asp Ile Asn Pro Asp Glu Asp Phe Lys His Leu Asp Arg Thr Glu Glu 
            180                 185                 190         


Asp Phe Asn Tyr Tyr Phe Thr Arg Asn Lys Lys Gly Asn Ile Thr Ala 
        195                 200                 205             


Ser Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala 
    210                 215                 220                 


Ile Trp Met Gln Gln Lys Leu Thr Gly Phe Lys Asp Asn Arg Glu Ser 
225                 230                 235                 240 


Lys Lys Lys Met Thr His Glu Val Phe Cys Arg Arg Arg Met Leu Leu 
                245                 250                 255     


Pro Lys Leu Arg Leu Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu 
            260                 265                 270         


Asp Met Leu Asn Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg 
        275                 280                 285             


Leu Gln Gly Val Asp Arg Glu Lys Phe Lys Val Pro Phe Asp Pro Ala 
    290                 295                 300                 


Asp Glu Asp Tyr Asp Ala Glu Gln Glu Pro Phe Lys Asn Thr Leu Val 
305                 310                 315                 320 


Arg His Gln Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Tyr 
                325                 330                 335     


Asn Glu Ile Phe Thr Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr 
            340                 345                 350         


His Phe Ser Ile Tyr Lys Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg 
        355                 360                 365             


His Leu Thr His Lys Leu Tyr Gly Phe Glu Arg Ile Gln Glu Phe Ala 
    370                 375                 380                 


Lys Gln Asn Arg Pro Asp Glu Trp Lys Ala Ile Val Lys Asp Leu Asp 
385                 390                 395                 400 


Thr Tyr Glu Thr Ser Asn Glu Arg Tyr Ile Ser Glu Thr Thr Pro His 
                405                 410                 415     


Tyr His Leu Glu Asn Gln Lys Ile Gly Ile Arg Phe Arg Asn Gly Asn 
            420                 425                 430         


Asn Asp Ile Trp Ala Ser Leu Glu Thr Asn Gly Glu Asn Asn Glu Lys 
        435                 440                 445             


Ser Lys Tyr Lys Leu Asp Lys Gln Tyr Gln Ala Glu Ala Phe Leu Ser 
    450                 455                 460                 


Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Lys Lys 
465                 470                 475                 480 


Glu Lys Pro Asn Asn Asp Glu Ile Asn Ala Ser Ile Val Glu Gly Phe 
                485                 490                 495     


Ile Lys Arg Glu Ile Arg Tyr Met Tyr Lys Leu Tyr Asp Ala Phe Ala 
            500                 505                 510         


Asn Gly Glu Ile Asn Asn Ile Asp Asp Leu Glu Lys Tyr Cys Glu Asp 
        515                 520                 525             


Lys Gly Ile Pro Lys Arg His Leu Pro Lys Gln Met Val Ala Ile Leu 
    530                 535                 540                 


Tyr Asp Glu His Lys Asp Met Val Glu Glu Ala Lys Arg Lys Gln Lys 
545                 550                 555                 560 


Glu Met Val Lys Asp Thr Lys Lys Leu Leu Ala Thr Leu Glu Lys Gln 
                565                 570                 575     


Thr Gln Gly Glu Ile Glu Asp Gly Gly Arg Asn Ile Arg Leu Leu Lys 
            580                 585                 590         


Ser Gly Glu Ile Ala Arg Trp Leu Val Asn Asp Met Met Arg Phe Gln 
        595                 600                 605             


Pro Val Gln Lys Asp Asn Glu Gly Asn Pro Leu Asn Asn Ser Lys Ala 
    610                 615                 620                 


Asn Ser Thr Glu Tyr Gln Met Leu Gln Arg Ser Leu Ala Leu Tyr Asn 
625                 630                 635                 640 


Lys Glu Glu Lys Pro Thr Arg Tyr Phe Arg Gln Val Asn Leu Ile Asn 
                645                 650                 655     


Ser Ser Asn Pro His Pro Phe Leu Lys Trp Thr Lys Trp Glu Glu Cys 
            660                 665                 670         


Asn Asn Ile Leu Ser Phe Tyr Arg Ser Tyr Leu Thr Lys Lys Ile Glu 
        675                 680                 685             


Phe Leu Asn Lys Leu Lys Pro Glu Asp Trp Glu Lys Asn Gln Tyr Phe 
    690                 695                 700                 


Leu Lys Leu Lys Glu Pro Lys Thr Asn Arg Glu Thr Leu Val Gln Gly 
705                 710                 715                 720 


Trp Lys Asn Gly Phe Asn Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile 
                725                 730                 735     


Arg Glu Trp Phe Lys Arg His Gln Asn Asn Ser Lys Glu Tyr Lys Asn 
            740                 745                 750         


Val Glu Asp Leu Lys Arg Val Gly Leu Val Thr Lys Val Ile Pro Leu 
        755                 760                 765             


Phe Phe Lys Glu Glu Tyr Phe Lys Glu Asp Ala Gln Lys Glu Ile Asn 
    770                 775                 780                 


Asn Cys Val Gln Pro Phe Tyr Ser Phe Pro Tyr Asn Val Gly Asn Ile 
785                 790                 795                 800 


His Lys Pro Asp Glu Lys Asp Phe Leu Pro Ser Glu Glu Arg Lys Lys 
                805                 810                 815     


Leu Trp Gly Asp Lys Lys Asn Lys Phe Lys Gly Tyr Lys Ala Lys Val 
            820                 825                 830         


Lys Ser Lys Lys Leu Thr Asp Lys Glu Lys Glu Glu His Arg Ser Tyr 
        835                 840                 845             


Leu Glu Phe Lys Ser Trp Asn Gln Phe Glu Arg Glu Leu Arg Leu Val 
    850                 855                 860                 


Arg Asn Gln Asp Ile Val Thr Trp Leu Leu Cys Met Glu Leu Ile Asp 
865                 870                 875                 880 


Lys Leu Lys Val Glu Gly Leu Asn Val Glu Glu Leu Lys Lys Leu Arg 
                885                 890                 895     


Leu Lys Asp Ile Asp Thr Asp Thr Ala Lys Gln Glu Lys Asn Asn Ile 
            900                 905                 910         


Leu Asn Arg Ile Met Pro Met Gln Leu Pro Val Thr Val Tyr Glu Ile 
        915                 920                 925             


Asp Asp Ser His Asn Ile Val Lys Asp Arg Pro Leu His Thr Val Tyr 
    930                 935                 940                 


Ile Glu Glu Thr Lys Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala 
945                 950                 955                 960 


Leu Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Val Asp Thr 
                965                 970                 975     


Ser Ser Glu Ala Glu Leu Lys Ser Asn Pro Ile Ser Lys Ser Val Val 
            980                 985                 990         


Glu Tyr Glu Leu Gly Glu Tyr Gln  Asn Ala Arg Ile Glu  Thr Ile Lys 
        995                 1000                 1005             


Asp Met  Leu Leu Leu Glu Glu  Thr Leu Ile Lys Lys  Tyr Lys Lys 
    1010                 1015                 1020             


Leu Pro  Thr Asn Asn Phe Ser  Ala Met Leu Asn Gly  Trp Leu Glu 
    1025                 1030                 1035             


Gly Lys  Asp Glu Ala Asp Lys  Ala Arg Phe Gln Asn  Asp Val Asp 
    1040                 1045                 1050             


Leu Leu  Ile Ala Val Arg Asn  Ala Phe Ser His Asn  Gln Tyr Pro 
    1055                 1060                 1065             


Met Arg  Asn Arg Ile Ala Phe  Ala Asn Ile Asn Pro  Phe Ser Leu 
    1070                 1075                 1080             


Ser Ser  Ala Asn Thr Ser Glu  Lys Lys Gly Leu Asp  Ile Ala Asn 
    1085                 1090                 1095             


Gln Leu  Lys Asp Lys Thr His  Lys Ile Ile Lys Arg  Ile Ile Lys 
    1100                 1105                 1110             


Ile Glu  Lys Pro Ile Glu Ser  Lys Glu 
    1115                 1120         


<210>  2281
<211>  1156
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2281

Met Glu Ser Gln Pro Lys Arg Thr Asp Gly Ile Thr Tyr Tyr Asp His 
1               5                   10                  15      


Lys Ser Asn Ser Asp Lys His Tyr Phe Gly Gly Tyr Leu Asn Gln Ala 
            20                  25                  30          


Leu Asn Asn Tyr Thr Val Ile Glu Lys Leu Phe Glu Gln Lys Phe Glu 
        35                  40                  45              


Glu Ser Leu Glu Asn Phe Leu Gln Lys Asn Lys Lys Val Ser Tyr Ala 
    50                  55                  60                  


Gln Trp Glu Arg Met Leu Asn Phe Leu Lys His His Phe Pro Val Val 
65                  70                  75                  80  


His Tyr Ile Asp Leu Pro Val Arg Glu Ala Thr Lys Asp Asn Pro Asp 
                85                  90                  95      


Pro Phe Pro Arg Asn Asp Ala Glu Arg Arg Gln His Phe Ile Thr Thr 
            100                 105                 110         


Phe Thr Ser Ile Lys Lys Leu Leu Phe Asp Leu Arg Asn Phe Tyr Ser 
        115                 120                 125             


His Tyr Phe His Glu Pro Ile Asp Thr Lys Ile Asp Thr Leu Ser His 
    130                 135                 140                 


Leu Asp Gln Ile Phe Val Ala Val Cys Glu His Val Lys Thr Lys Arg 
145                 150                 155                 160 


Met Lys Thr Asp Glu Thr Arg Leu Leu Leu Lys Glu Thr Leu Ala Asp 
                165                 170                 175     


Glu Leu Thr His Leu Phe Ile Leu Lys Glu Lys Glu Leu Leu Glu Leu 
            180                 185                 190         


Lys Lys Lys Val Gly Ile Thr Gly Lys Thr Thr Ala Glu Glu Val Arg 
        195                 200                 205             


Asn Ala Ile Phe Asn Asp Ser Phe Lys His Leu Tyr Tyr Glu Lys Gln 
    210                 215                 220                 


Pro Ser Arg Ile Tyr Arg Ser Ser Leu Gln Glu Glu Ala Ala Thr Glu 
225                 230                 235                 240 


Asn Gly Ile Thr Ile Ser Gln Ser Gly Leu Ser Leu Ile Leu Ser Phe 
                245                 250                 255     


Phe Leu Ser Lys Arg Glu Met Glu Gly Phe Lys Ser Arg Leu Arg Gly 
            260                 265                 270         


Leu Lys Gly Arg Val Leu Asn Leu Glu Asn Gly Asn Ile Asp Leu Arg 
        275                 280                 285             


Asn Asn Ser Leu Arg Phe Met Ala Thr His Trp Val Phe Ser Tyr Leu 
    290                 295                 300                 


Cys Phe Lys Gly Pro Asn Gln Lys Leu Asn Thr Ser Tyr Leu Glu Glu 
305                 310                 315                 320 


Thr Leu Leu Val Gln Ile Ile Asp Glu Leu Thr Lys Val Pro His Glu 
                325                 330                 335     


Val Tyr Glu Ala Leu His Val Val Gln Arg Asp Lys Phe Val Glu Asp 
            340                 345                 350         


Ile Asn Glu Phe Met Arg Gln Asp Leu Glu Asp Gly Ser Glu Glu Asn 
        355                 360                 365             


Ala Leu Val Val His Pro Val Ile Arg Lys Arg Cys Glu Asn Lys Phe 
    370                 375                 380                 


Asn Tyr Phe Ala Leu Arg Tyr Leu Asp Glu Phe Ala Gly Phe Lys Thr 
385                 390                 395                 400 


Leu Arg Phe Gln Ile Asn Ile Gly Asn Tyr Ile His Asp Arg Arg Ser 
                405                 410                 415     


Lys Glu Leu Lys Ser Gly Ser Phe Ile Thr Asp Arg Glu Val Lys Glu 
            420                 425                 430         


Arg Ile Asn Val Phe Gly Arg Leu Ser Ala Val Thr Thr Leu Lys Asp 
        435                 440                 445             


Asp Phe Phe Arg Ser Glu Ser Tyr Glu Gly Ser Ser Trp Glu Arg Phe 
    450                 455                 460                 


Pro Asn Pro Ser Tyr Asn Ile Asn Gly Asn Asn Ile Ala Ile Tyr Leu 
465                 470                 475                 480 


Asp Leu Gly Lys Asp His Gly Lys Asp Thr Lys Val Ile Tyr Asp Ala 
                485                 490                 495     


Arg Ser Lys Arg Asn Lys Lys Glu Glu Arg Val Asp Arg Ser Asn Gly 
            500                 505                 510         


Lys Pro Thr Lys Asp Asp Ile Leu Lys Glu Leu Gln Gln Ala Val Glu 
        515                 520                 525             


Val Lys Ser Asp Thr Ile His Arg Lys Glu Pro Thr Ala Leu Leu Ser 
    530                 535                 540                 


Leu His Glu Leu Pro Ala Leu Leu Tyr Glu Leu Leu Val Asn His Val 
545                 550                 555                 560 


Lys Pro Glu Thr Ile Glu Thr Ile Leu Ala Gly Lys Ile Ser Glu Arg 
                565                 570                 575     


Leu Lys Val Ile Gln Glu Tyr Thr Pro Gln Ser Asp Leu Pro Leu Ser 
            580                 585                 590         


Gln Ile Pro Lys Asn Leu Lys Val Ser Gly Gln Glu Pro Lys Val Gln 
        595                 600                 605             


Tyr Asp Lys Leu Ile Arg Leu Ile Asp Asn Leu Ile Ala Ala Gly Glu 
    610                 615                 620                 


Asp Lys Ser Ala Leu Ile Ser Lys Asn Gln Arg Glu Ile Ala Asn Pro 
625                 630                 635                 640 


Lys Ile Lys Arg Asn Phe Val Phe Thr Ile Thr Glu Arg Gly Arg Glu 
                645                 650                 655     


Ala Asn Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Glu Ser Thr 
            660                 665                 670         


Lys Gly Gln Trp Lys Gly Tyr His His Ser Gln Leu Gln Glu Ile Leu 
        675                 680                 685             


Ala Phe Tyr Phe Ala Arg Lys Gln Asp Ala Ile Ser Leu Leu Asn Ser 
    690                 695                 700                 


Val Trp Gln Leu Lys Gln Ser Asp Phe Gly Ala Ser Leu Glu Val Leu 
705                 710                 715                 720 


Phe Leu Lys Pro Gly Phe Asp Ser Phe Tyr Ile Ala Tyr Leu Gln Asn 
                725                 730                 735     


Arg Lys Glu His Leu Gly Gln Ile Arg Asp Arg Ile Leu Gln Tyr Gln 
            740                 745                 750         


Ser Glu Lys Asn Val Ile Lys Lys Val Leu Lys Ser Ile Asp His Ile 
        755                 760                 765             


Phe Pro Lys Lys Val Tyr Thr Ile Arg Ser Thr Gln Asp Gln Ile Glu 
    770                 775                 780                 


Asn Leu Leu Gly Lys Pro Ile Ala Phe Ser Arg Gly Ile Phe Asp Ser 
785                 790                 795                 800 


Lys Pro Thr Phe Ile Thr Asp Thr Thr Phe Glu Gly Asn Glu His Leu 
                805                 810                 815     


Phe Ala Asp Trp Tyr Arg Thr Ser Arg Asp Lys Ser Ile Ala Phe Gln 
            820                 825                 830         


Ser Phe Tyr Asn Leu Pro Lys Asp Tyr Ser Glu Leu Ile Ser His Ala 
        835                 840                 845             


Lys Glu Thr Gly Lys Arg Ile His Asp Leu Ser Ala Arg Val Lys Met 
    850                 855                 860                 


Asn Thr Asp Leu Asn Ile Lys Asn Val Gln Ile Lys Asp Phe Phe Leu 
865                 870                 875                 880 


Lys Lys Ile Ala Asp Ala Leu Phe Gln Lys Cys Leu Gly Gln Thr Phe 
                885                 890                 895     


Ala Asn Ser Glu Gly Asn Asp Leu Ala Asn Leu Thr Leu Glu Gln Leu 
            900                 905                 910         


Tyr Leu Glu Arg Glu Glu Arg Lys Gln Ile Asn Leu Asn Ala Lys Leu 
        915                 920                 925             


Gln Tyr Gln Arg Lys Pro Gly Ser Leu Ser Asn Asn Ile Tyr Asn Asp 
    930                 935                 940                 


Ser Phe Ile Trp Asn Lys Pro Ile Gln Phe Lys Ala Asp Gln Ile Glu 
945                 950                 955                 960 


Glu Ser Lys Val Lys Leu Lys Asp Leu Gly Lys Ile Lys Arg Phe Ile 
                965                 970                 975     


Ala Asp Thr Lys Val Thr Gln Leu Leu Ala Tyr Ala Pro Thr Arg Val 
            980                 985                 990         


Trp Ser Ile Gly Glu Leu Glu Asp  Glu Leu Asn Leu Lys  Ala Arg Cys 
        995                 1000                 1005             


Tyr Glu  Thr Ile Arg Arg Glu  Gln Ile Leu Lys Asp  Leu Phe Asn 
    1010                 1015                 1020             


Phe Glu  Lys Gln Ile Leu Thr  Ser Leu Asn Phe Asn  Gly Gln Val 
    1025                 1030                 1035             


Glu Pro  Pro Ser Leu Ala Ile  His Thr Asn His Lys  Phe Arg Ala 
    1040                 1045                 1050             


Tyr Val  Ala Glu Gly Val Leu  Arg Arg Lys Gly His  Ile Glu Ser 
    1055                 1060                 1065             


Ala Ser  Trp Leu Ile Asn Ile  Asp Phe Glu Lys Thr  Gly Val Lys 
    1070                 1075                 1080             


Glu Leu  Arg Glu Ala Thr Ser  Leu Ser Ile Asp Ser  Phe Leu Leu 
    1085                 1090                 1095             


Val Leu  Ile Arg Asn Lys Phe  Met His Asn Gln Leu  Pro Pro Leu 
    1100                 1105                 1110             


Pro Phe  Tyr Glu Phe Met Cys  Glu Arg Tyr Pro Lys  Asn Glu Gly 
    1115                 1120                 1125             


Glu Thr  Phe Ser Glu Phe Phe  Phe Arg Ile Ala Ala  Ala Ile Met 
    1130                 1135                 1140             


Lys Lys  Leu Ile Asn Leu Asp  Val Lys Ile Ala Val  Ala 
    1145                 1150                 1155     


<210>  2282
<211>  1057
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2282

Met Thr Ile Lys Glu Gln Ser His Phe Ala Ala Tyr Tyr Asn Met Ala 
1               5                   10                  15      


Arg His Asn Met Tyr Glu Thr Leu Cys Tyr Ile Ser Lys Ile Ser Gly 
            20                  25                  30          


Ile Gln Glu Gly Glu Asp Asn Lys Glu Ser Lys Ile Glu Asp Met Gln 
        35                  40                  45              


Leu Leu Arg Val Leu Thr Thr Lys Gly His Pro Glu Glu Lys Ile Arg 
    50                  55                  60                  


Ile Glu Lys Leu Ile Tyr Lys His Leu Pro Leu Phe Arg Pro Ala Val 
65                  70                  75                  80  


Glu Asp Leu Arg Lys Lys Ser Lys Glu Asn Val Lys Ser Pro Glu Leu 
                85                  90                  95      


Leu Ala Lys Val Ile Lys Asn Trp Ala Lys Val Ile Thr Tyr Tyr Arg 
            100                 105                 110         


Asp Lys Phe Thr His Tyr Val Phe Ile Asp Lys Arg His Glu Asn Lys 
        115                 120                 125             


Glu Phe Leu Asn Ala Glu Met Ser Val Ala Asn Asp Leu Asn Gln Ile 
    130                 135                 140                 


Phe Thr Ala Ser Ala Arg Val Ile Lys Glu Arg Phe Gly Leu Ser Thr 
145                 150                 155                 160 


Glu Leu Glu Phe Leu Thr Lys Gly Arg Tyr Arg Thr Gln Thr Ile Asp 
                165                 170                 175     


Gly Lys Arg Ser Thr Lys Leu Asn Pro Asn Phe Ile Tyr Ser Leu Gln 
            180                 185                 190         


Asp Lys Asn Glu Arg Leu Asn Lys Met Gly Leu Ile Phe Leu Ala Cys 
        195                 200                 205             


Gln Leu Ile Glu Lys Lys Tyr Ala Ser Met Leu Phe Asp Gln Gln Gly 
    210                 215                 220                 


Tyr Met Gly Arg Asp Ile Tyr Phe Asp Phe Thr Pro Ala Gln Cys Lys 
225                 230                 235                 240 


Tyr Ile Arg Glu Val Phe Ser Ala His Arg Ile Val Leu Pro Arg Gly 
                245                 250                 255     


Arg Met Asp Val Glu Arg Asn Glu Ile Thr Ile Ala Met Asp Met Phe 
            260                 265                 270         


Asn Glu Leu Gly Lys Cys Pro Lys Glu Leu Phe Glu Ile Ile Ser Lys 
        275                 280                 285             


Glu Glu Gln Lys Arg Phe Arg Thr Lys Ser Glu Thr Thr Gly Glu Glu 
    290                 295                 300                 


Val Leu Leu Met Arg His Ser Asp Arg Phe Ala Thr Leu Ala Leu Gln 
305                 310                 315                 320 


Tyr Ile Asp Asn Arg Lys Val Phe Glu Lys Ile Arg Phe Gln Leu Ser 
                325                 330                 335     


Leu Gly Lys Tyr Arg Tyr Lys Phe Tyr Asp Lys Thr Cys Val Asp Gly 
            340                 345                 350         


Asp Thr His Val Arg Ile Leu Gln Lys Glu Leu Asn Gly Phe Gly Arg 
        355                 360                 365             


Ile Asn Glu Ile Glu Leu Leu Lys Glu Glu Lys Trp Gly Gly Leu Ile 
    370                 375                 380                 


Arg Lys Phe Glu Asp Ala Lys Ile Asp Thr Ala Glu Thr Lys Pro Tyr 
385                 390                 395                 400 


Ile Thr Asp Gln Tyr Pro Gln Tyr Leu Phe Asn Gly Asn Arg Ile Gly 
                405                 410                 415     


Ile Tyr Phe Asn Ser Ala His Gly Lys Ala Met Arg Asn Gly Ala Tyr 
            420                 425                 430         


Ile Pro Asp Ile Glu Ser Gly Ala His Cys Ile Gln Pro Ile Cys Trp 
        435                 440                 445             


Ile Ser Asn Tyr Glu Leu Pro Ala Leu Ile Phe His His Ile Leu Thr 
    450                 455                 460                 


Lys Asp Glu Lys Lys Ser Leu Thr Glu Lys Ile Ile Ile Asp Cys Val 
465                 470                 475                 480 


Glu Arg Tyr Lys Lys Leu Phe Asn Asp Ile Ala Glu Gly Lys Val Ala 
                485                 490                 495     


Arg Thr Gly Asn Ala Thr Ser Asp Phe Glu Met Ile Ser Lys Glu Tyr 
            500                 505                 510         


Gly Ile Glu Lys Ser Asp Ile Pro Arg Glu Leu Gln Asp Tyr Phe Asn 
        515                 520                 525             


Gly Thr Glu Arg Asp Gly Ile Glu Gln Tyr Ala Lys Ala Gln Ile Arg 
    530                 535                 540                 


Glu Met Ile Glu Glu Asn Arg Ile Arg Leu Glu Gln Phe Asn Ser Lys 
545                 550                 555                 560 


Leu Lys Lys Ile Glu Asp Gly Glu Val Lys Tyr Gly Lys Arg Asp Tyr 
                565                 570                 575     


Thr Glu Ile Arg Thr Gly Glu Leu Ala Gln Tyr Leu Ala Lys Asp Ile 
            580                 585                 590         


Val Met Phe Met Pro Lys Ala Lys Tyr Lys Pro Thr Ser Lys Asn Tyr 
        595                 600                 605             


Asn Val Met Gln Ala Leu Leu Ala Thr Phe Asn Gly Ser Glu Ser Gly 
    610                 615                 620                 


Ser Thr Leu Asp Glu Val Asp Asp Met Phe Asp Asn Ile Lys Ala Cys 
625                 630                 635                 640 


Tyr Trp Lys Asn Glu Ser Asp Asn His Pro Phe Leu Glu Tyr Val Leu 
                645                 650                 655     


Gly Glu Glu Pro Lys Asp Ile Ile Ala Phe Tyr Lys Ile Tyr Leu Glu 
            660                 665                 670         


Leu Arg Gly Glu Tyr Leu Asp Lys Cys Ile Lys Lys Met Asp Leu Ala 
        675                 680                 685             


Thr Ile Pro Phe Ile His Thr Glu Arg Lys Arg Trp Glu Lys Arg Asp 
    690                 695                 700                 


Glu Lys Phe Phe Lys Glu Leu Ala Gln Arg Tyr Ala Thr Gln Pro Ile 
705                 710                 715                 720 


Glu Leu Pro Arg Gly Leu Tyr Asp Arg Ala Ile Lys Glu Tyr Leu Lys 
                725                 730                 735     


Ser Lys Ser Ile Leu Glu Asp Val Ile Ala Gln Glu Gln Cys Asn Val 
            740                 745                 750         


Thr Tyr Leu Ile Ala Arg Tyr Met Gln Asp Val Leu Lys Asp Asp Ser 
        755                 760                 765             


Gln Gln Phe Tyr Ser Leu Pro Arg His Tyr Ser Cys Leu Ser Glu Lys 
    770                 775                 780                 


Asp Lys Tyr Leu Ser Leu Thr Glu Arg Glu Ala Ile Ala Lys Ser Asp 
785                 790                 795                 800 


Ala Leu Asn Ser Phe Lys Lys Arg Glu Arg Glu Lys Glu Asn Glu Asn 
                805                 810                 815     


Arg Arg Gly Asn Arg Arg Tyr Asn Lys Gly Glu Asn Lys Asn Thr Ile 
            820                 825                 830         


Lys Asp Arg Asp Thr Glu Glu Lys Phe Asn Ser Leu Tyr Arg Lys Met 
        835                 840                 845             


Asp Asn Asn Glu Arg Ile Leu Arg Arg Tyr Lys Val Gln Asp Met Leu 
    850                 855                 860                 


Leu Tyr Leu Leu Ala Cys Asp Ile Ile Lys Gly Ile Met Arg Glu Asp 
865                 870                 875                 880 


Phe Gly Tyr Lys Leu Ser Met Ile Thr Asp Gly Lys Asn Ser Asn Phe 
                885                 890                 895     


Phe Asp Tyr Lys Met Pro Glu Phe Lys Thr Thr Ile Thr Leu Lys Glu 
            900                 905                 910         


Gly Lys Lys Phe Thr Ile Lys Gln Gln Tyr Leu Lys Ile Lys Asn Tyr 
        915                 920                 925             


Gly Asp Phe Leu Lys Phe Ile Phe Asp Leu Arg Ile Asp Ser Leu Leu 
    930                 935                 940                 


Ser Asn Gly Thr Lys Val Glu Ile Asp Arg Asn Ile Leu Glu Asp Glu 
945                 950                 955                 960 


Leu Ser Asn Tyr Asp Gly Ser Arg Pro Lys Val Phe Glu Thr Leu Leu 
                965                 970                 975     


Met Ile Glu Lys Ile Val Val Glu Lys His Lys Glu Leu Lys Asp Leu 
            980                 985                 990         


Glu His Ile Thr Phe Gly Asp Val  Leu Asn Val Ile Lys  Met Glu Glu 
        995                 1000                 1005             


Gly Glu  Lys Lys Ile Leu Arg  Leu Ile Arg Asn Ala  Phe Ser His 
    1010                 1015                 1020             


Asn Tyr  Tyr Pro Thr Ile Lys  Asp Val Asn Tyr Asp  Asn Met Pro 
    1025                 1030                 1035             


Glu Val  Ala Glu Ser Leu Lys  Asp Ile Leu Glu Lys  Glu Ser Lys 
    1040                 1045                 1050             


Lys Leu  Thr Asn 
    1055         


<210>  2283
<211>  1098
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2283

Met Glu Asn Asp Lys Arg Leu Glu Glu Ser Ala Cys Tyr Thr Leu Asn 
1               5                   10                  15      


Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val 
            20                  25                  30          


Tyr Ile Thr Val Asn His Ile Asn Lys Thr Leu Gly Glu Gly Glu Ile 
        35                  40                  45              


Asn Arg Asp Gly Tyr Glu Thr Thr Leu Glu Asn Thr Trp Asn Glu Ile 
    50                  55                  60                  


Lys Asp Ile Asn Lys Lys Ala Arg Leu Arg Glu Leu Ile Ile Lys His 
65                  70                  75                  80  


Phe Pro Phe Leu Glu Ala Ala Thr Tyr Gln Gln Arg Ser Thr Asp Ser 
                85                  90                  95      


Thr Lys Gln Lys Glu Glu Lys Gln Ala Glu Ala Gln Ser Leu Glu Ser 
            100                 105                 110         


Leu Lys His Cys Leu Phe Pro Phe Leu Lys Lys Leu Gln Lys Ser Arg 
        115                 120                 125             


Asp His Tyr Ser His Tyr Lys His Ser Lys Ser Leu Glu Arg Pro Lys 
    130                 135                 140                 


Phe Glu Glu Asp Leu Gln Lys Lys Met Tyr Asn Ile Phe Asp Val Ser 
145                 150                 155                 160 


Ile Arg Leu Val Lys Glu Asp Tyr Lys His Asn Thr Asp Ile Asn Leu 
                165                 170                 175     


Lys Glu Asp Phe Lys His Leu Asn Arg Thr Gly Lys Phe Lys Tyr Ser 
            180                 185                 190         


Phe Ala Asp Asn Lys Gly Asn Ile Thr Glu Ser Gly Leu Leu Phe Phe 
        195                 200                 205             


Ile Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Met Gln Lys Lys 
    210                 215                 220                 


Leu Lys Gly Phe Lys Asp Ser Arg Glu Lys Tyr Gln Lys Met Thr Asn 
225                 230                 235                 240 


Glu Val Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu Glu 
                245                 250                 255     


Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu Asn Glu Leu 
            260                 265                 270         


Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Arg Glu Lys Glu Arg 
        275                 280                 285             


Lys Glu Phe Lys Val Pro Ile Glu Ile Ala Asp Glu Asp Tyr Asp Ala 
    290                 295                 300                 


Glu Gln Glu Pro Phe Arg Asn Thr Leu Val Arg His Gln Asp Arg Phe 
305                 310                 315                 320 


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Tyr Asn Glu Ile Phe Thr Asn 
                325                 330                 335     


Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile Tyr Lys 
            340                 345                 350         


Lys Leu Ile Gly Gly Asn Lys Glu Asp Arg His Leu Thr His Lys Leu 
        355                 360                 365             


Tyr Gly Phe Glu Arg Ile Gln Glu Phe Ala Lys Gln Asn Arg Pro Asp 
    370                 375                 380                 


Glu Trp Lys Ala Leu Val Lys Asp Leu Asp Thr Phe Asn Lys Glu Glu 
385                 390                 395                 400 


Glu Lys Pro Tyr Ile Ser Glu Thr Thr Pro His Tyr His Leu Glu Asn 
                405                 410                 415     


Glu Lys Ile Gly Ile Val Phe Lys Asn His Asn Ile Trp Pro Ser Thr 
            420                 425                 430         


Lys Thr Glu Leu Thr Asn Asn Asn Arg Lys Lys Tyr Asn Leu Gly Ala 
        435                 440                 445             


Ser Ile Lys Ala Glu Ala Phe Leu Ser Val His Glu Leu Leu Pro Met 
    450                 455                 460                 


Met Phe Tyr Tyr Leu Leu Leu Lys Thr Lys Asn Thr His Asn Gly Asn 
465                 470                 475                 480 


Glu Val Glu Ala Lys Lys Lys Gly Thr Lys Asn Lys Lys Gln Glu Lys 
                485                 490                 495     


His Lys Ile Glu Ala Ile Ile Glu Ser Lys Ile Lys Asp Ile Tyr Asn 
            500                 505                 510         


Leu Tyr Asp Ala Phe Ala Asn Gly Glu Ile Asn Ser Ile Glu Glu Leu 
        515                 520                 525             


Glu Glu His Cys Lys Gly Lys Asp Ile Glu Ile Gly His Leu Pro Lys 
    530                 535                 540                 


Gln Met Ile Ala Ile Leu Lys Asp Glu His Lys Asp Met Ala Lys Lys 
545                 550                 555                 560 


Ala Glu Thr Lys Gln Glu Lys Met Ile Leu Ala Thr Glu Asn Arg Leu 
                565                 570                 575     


Lys Thr Leu Asp Lys Lys Leu Lys Gly Lys Ile Arg Asn Gly Lys Arg 
            580                 585                 590         


Cys Asn Ser Ala Leu Lys Ser Gly Glu Ile Ala Ser Trp Leu Val Asn 
        595                 600                 605             


Asp Met Met Arg Phe Gln Pro Val Gln Arg Asp Glu Glu Gly Lys Pro 
    610                 615                 620                 


Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln Leu Leu Gln Arg 
625                 630                 635                 640 


Thr Leu Ala Phe Phe Gly Ser Glu His Glu Arg Leu Asp Pro Tyr Phe 
                645                 650                 655     


Lys Gln Met Asn Leu Ile Gly Asp Asn Asn Pro His Pro Phe Leu Lys 
            660                 665                 670         


Glu Thr Lys Trp Glu Glu Cys Asn Asn Ile Leu Ser Phe Tyr Arg Ser 
        675                 680                 685             


Tyr Leu Glu Ala Lys Lys Asn Phe Leu Glu Ser Leu Lys Pro Glu Asp 
    690                 695                 700                 


Trp Lys Lys Asn Gln Tyr Phe Leu Met Leu Lys Glu Pro Lys Asn Asn 
705                 710                 715                 720 


Arg Glu Thr Leu Val Gln Gly Trp Lys Asn Gly Phe Asn Leu Pro Arg 
                725                 730                 735     


Gly Ile Phe Thr Glu Pro Ile Arg Lys Trp Phe Met Glu His Arg Lys 
            740                 745                 750         


Lys Ile Lys Ala Asp Glu Leu Lys Arg Val Gly Phe Val Ala Lys Val 
        755                 760                 765             


Ile Pro Leu Phe Phe Ser Lys Glu Tyr Lys Asp Gly Val Gln Pro Phe 
    770                 775                 780                 


Tyr Asn Tyr Pro Phe Asn Val Gly Asn Ile Asn Lys Pro Glu Glu Lys 
785                 790                 795                 800 


Asp Phe Leu Asp Tyr Glu Lys Arg Lys Lys Leu Trp Asp Lys Lys Gln 
                805                 810                 815     


Ala Lys Phe Lys Gly Lys Thr Asp Lys Glu Lys Arg Glu Asp Pro Ser 
            820                 825                 830         


Tyr Pro Asp Phe Lys Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu 
        835                 840                 845             


Val Arg Asn Gln Asp Ile Val Thr Trp Met Leu Cys Met Glu Leu Phe 
    850                 855                 860                 


Glu Glu Gln Lys Val Asp Gly Leu Asn Thr Gly Gln Ile His Leu Lys 
865                 870                 875                 880 


Asp Ile Val Thr Asn Val Asp Glu Glu Gly Asn Asn Asn Ile Leu Asn 
                885                 890                 895     


Gln Ile Lys Pro Met Gln Leu Pro Ile Thr Val Tyr Asp Lys Glu Asn 
            900                 905                 910         


Ser Pro Lys Arg Lys Pro Leu His Thr Val Tyr Ile Glu Glu Thr Gly 
        915                 920                 925             


Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys Asp Arg 
    930                 935                 940                 


Arg Leu Asn Gly Leu Phe Ser Phe Val Lys Thr Ser Ser Glu Ala Glu 
945                 950                 955                 960 


Ser Lys Ser Lys Pro Ile Ser Lys Ser Arg Val Glu Tyr Glu Leu Gly 
                965                 970                 975     


Ala Tyr Gln Lys Ala Arg Ile Asp Ile Ile Lys Asp Met Leu Ala Leu 
            980                 985                 990         


Glu Lys Thr Leu Ile Asp Asn Asp  Glu Asn Leu Pro Thr  Asn Lys Phe 
        995                 1000                 1005             


Ser Asp  Met Leu Lys Ser Trp  Leu Lys Gly Lys Gly  Glu Ala Asn 
    1010                 1015                 1020             


Lys Val  Arg Phe Gln Asn Asp  Val Asp Leu Leu Val  Ala Val Arg 
    1025                 1030                 1035             


Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met Tyr Asn  Ser Glu Val 
    1040                 1045                 1050             


Phe Lys  Gly Met Lys Leu Leu  Ser Leu Ser Ser Asp  Ile Pro Glu 
    1055                 1060                 1065             


Lys Glu  Gly Leu Gly Ile Ala  Lys Gln Leu Lys Asp  Lys Ile Lys 
    1070                 1075                 1080             


Glu Thr  Ile Glu Arg Ile Ile  Glu Ile Glu Lys Glu  Ile Arg Asn 
    1085                 1090                 1095             


<210>  2284
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2284

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2285
<211>  1147
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2285

Met Lys Ile Gln Asp Pro Leu Leu Ala Val Tyr Thr Asn Met Ala Arg 
1               5                   10                  15      


His Asn Val Phe Asn Ile Ile Arg Ala Ala Gln Asp Ala Phe Ser Ile 
            20                  25                  30          


Thr Thr Pro Lys Lys Leu Lys Asp Asp Ala Gly Ile Ala Met Asp Ser 
        35                  40                  45              


His Phe Leu Met Lys Leu Leu Glu Arg Asp Tyr Ala Phe Pro Asp Gln 
    50                  55                  60                  


Arg Arg Trp Lys Val Ile Asn Tyr Leu Lys Asn Arg Asn Tyr Leu Pro 
65                  70                  75                  80  


Ile Leu His His Phe Tyr His Glu Leu Glu Ala Lys Met Val Lys Glu 
                85                  90                  95      


Tyr Glu Gly Lys Ala Ser Ala Glu Lys Pro Glu Thr Asn Phe Phe Asn 
            100                 105                 110         


Ser Val Lys Asp Tyr Leu Ala Trp Cys Phe Thr Thr Leu Asn Thr Leu 
        115                 120                 125             


Arg Asn Ala Ser Thr His Met His Val Tyr Lys Ala Asn Thr Asn Ala 
    130                 135                 140                 


Glu Tyr Asp Pro Leu His Leu Pro Asn Glu Tyr Leu Ile Ile Leu Asn 
145                 150                 155                 160 


Asn Leu Tyr Glu Ser Ala Lys Ala Thr Ala Lys Ser Lys Phe Gly Glu 
                165                 170                 175     


Ala Leu Gly Asn His Leu Phe Asp Gln Ser Asn Lys Ile Asp Phe Gln 
            180                 185                 190         


Thr Asn Asp Asn Gln Phe Ser Lys Leu Gly Leu Ala Phe Phe Ile Cys 
        195                 200                 205             


Gln Phe Leu Asp Gln Arg Asn Ala Thr Ile Tyr Leu Gln Lys Thr Gly 
    210                 215                 220                 


Val Leu Asn His Phe Thr Gly Lys Leu Arg Leu Ala His Ile Lys Cys 
225                 230                 235                 240 


Phe Thr Thr Tyr Cys Val Lys Thr Pro Glu Lys Lys Ile Thr Asn Glu 
                245                 250                 255     


Asn Gln Glu Gln Ser Leu Leu Leu Gln Ile Met Gln Asp Leu Glu Arg 
            260                 265                 270         


Cys Pro Asn Asn Leu Tyr Met Gln Leu Ser Asp Asp Asp Lys Lys Lys 
        275                 280                 285             


Leu Gln Pro Gln Leu Ser Glu Asp Gln Val Asn Arg Ile Ile Glu Asn 
    290                 295                 300                 


Ser Leu Ser Gly Asn Ile Asn Tyr Asp Ile Glu Leu Glu Gln Leu Val 
305                 310                 315                 320 


Lys Glu Leu Ser Gly Tyr Arg Arg Pro Arg Asn Arg Phe Asn Tyr Phe 
                325                 330                 335     


Ala Val Arg Phe Leu Asp Ile Lys Asp Ala Leu Gly Lys Tyr Lys Phe 
            340                 345                 350         


Gln Leu Ser Met Gly Lys Leu Leu Leu Arg Thr Tyr Thr Lys Lys Ile 
        355                 360                 365             


Leu Ser Thr Glu Asp Glu Arg Arg Ile Leu Arg Glu Leu Phe Val Gly 
    370                 375                 380                 


Gly Asn Leu Gln Asn Phe Gln Asp Glu Asp Glu Val Leu Asn Thr Tyr 
385                 390                 395                 400 


Thr Lys Arg Asn Pro Ser Asp Thr Glu Val Thr Phe Glu Gln Phe Ser 
                405                 410                 415     


Pro Lys Tyr Asn Ile Val Asp Asn Thr Ile Ala Ile Tyr Asp Lys Glu 
            420                 425                 430         


Phe Tyr Pro Thr Asn Arg Gly Lys Thr Asn Lys Thr Lys Glu Glu Lys 
        435                 440                 445             


Ala Ala Val Asn Gln Pro Lys Ala Tyr Leu Ser Leu Arg Ala Ser Tyr 
    450                 455                 460                 


Lys Met Ala Leu Leu Tyr Val Leu His Asn Asp Glu Asp Ile Leu Glu 
465                 470                 475                 480 


Asn Ile Ile Thr Lys His Ile Gly Glu Phe Asn Pro Phe Glu Ile Leu 
                485                 490                 495     


Ser Ser Gln Thr Val Phe Asp Ile His Ala Glu Leu Lys Lys Glu Glu 
            500                 505                 510         


Glu Arg Phe Ala Ser Pro Leu Arg Gln Val Ser Ala Asp Asp Thr Lys 
        515                 520                 525             


Met Ile Phe Pro Lys Arg Asn Ser Pro Asn Gln Ser Phe Tyr Lys Ala 
    530                 535                 540                 


Arg Glu Arg Tyr Val Lys Glu Leu Lys Tyr Arg Lys Asn Ile Leu Gln 
545                 550                 555                 560 


Asp Gln Phe Ile Lys Arg Asn Ile Asp Ile Asn Val Asn Ser Leu Pro 
                565                 570                 575     


Glu Lys Leu Leu His Tyr Leu Leu Asn Val Asn Ser Leu Pro Ser Ser 
            580                 585                 590         


Thr Gln Asn Asp Ser Glu Met Ala Lys Lys Phe Glu Lys Glu Phe His 
        595                 600                 605             


Lys Lys Ile Arg Phe Glu Asn Asp Gln Ala Lys Ser Ile Cys Lys Lys 
    610                 615                 620                 


Ile Glu Glu Asn Lys Asn Asp Leu Ser Asn Ile Lys Leu Gly Lys Leu 
625                 630                 635                 640 


Ala Thr Leu Val Thr Lys Asp Ile Met Lys Gln Met Ile Asn Val Gly 
                645                 650                 655     


Glu Lys Asn Lys Phe Thr Thr Pro Tyr Tyr Arg Glu Leu Gln Ser Ala 
            660                 665                 670         


Ile Ala His Phe Ser Thr Asn Lys Gln Lys Ile Ile Thr Phe Cys Asp 
        675                 680                 685             


Tyr Phe Ser Leu Phe Lys Asn Lys Val Gly His Pro Phe Leu Thr Lys 
    690                 695                 700                 


Asn Leu Ile Thr Asn Ala Thr Gly Val Ile His Phe Thr Glu Leu Tyr 
705                 710                 715                 720 


Phe Gln Ala Lys Thr Asn Trp Phe Arg Asn Asn Phe Leu Lys Lys Gly 
                725                 730                 735     


Ser Lys Glu Glu Asp Tyr Lys Asp Gly Gly Phe Lys Val Asn Glu Asp 
            740                 745                 750         


Gln Ile Thr Lys Leu Pro Tyr Ser Leu Arg Thr Trp Ile Ala Lys Arg 
        755                 760                 765             


Thr Lys Asn Phe Asp Ile Ile Glu Trp Trp Asn Asn Lys Ile Gly Lys 
    770                 775                 780                 


Pro Val Asn Leu Pro Glu Asn Ile Phe Asp Asp Glu Leu Lys Arg Ala 
785                 790                 795                 800 


Leu Ile Lys Glu Ile Pro Pro Glu Gln Leu Pro Val Pro Glu Gln Gln 
                805                 810                 815     


Lys Ile Gly Lys Leu Leu Arg Ile Phe Ile Gln Asn Asp Glu Gln Phe 
            820                 825                 830         


Phe Tyr Gly Phe Lys Arg Tyr Tyr Ser Tyr Asn Thr Lys Ala Thr Lys 
        835                 840                 845             


Ser Glu Glu Lys Lys Phe Ile Tyr Asp Pro Lys Val Thr Gln Asn Val 
    850                 855                 860                 


Lys Ser Ala Thr Met Asn Ile Asn Trp Val Asn Asn His Glu Lys Arg 
865                 870                 875                 880 


Ile Arg Phe Thr Arg Thr Lys Asp Arg Val Ala Leu Lys Leu Ala Glu 
                885                 890                 895     


Met Leu Ala Thr Glu Lys Gly Phe Ser Thr Asn Asn Met Gln Leu Lys 
            900                 905                 910         


Gln Phe Val Pro Asn Ala Gln Asn Ser Pro Leu Lys Gln Pro Ile Arg 
        915                 920                 925             


Phe Glu Lys Ile Ile Asn His Asp Glu Ile Glu Asp Asn Phe Asn Gly 
    930                 935                 940                 


Glu Lys Asn Phe Tyr Thr Ile Pro Glu Lys Ile Ile Val Ala Asp Asp 
945                 950                 955                 960 


Lys Leu Ser Asp Lys Tyr Glu Asn Gln Glu Arg Glu Ser Lys Trp Asn 
                965                 970                 975     


Tyr Gln Ser Tyr Ser Arg Phe Asn Arg Val Val Tyr Asp Lys Arg Leu 
            980                 985                 990         


Pro Gly Leu Leu Ser Ala Phe Glu  Ala Lys Thr Ile Pro  Phe Glu Leu 
        995                 1000                 1005             


Leu Glu  Tyr Glu Leu Asn Ser  Tyr Asp Asn Glu Trp  Leu Lys Ile 
    1010                 1015                 1020             


Ile Glu  Lys Thr Ala Gln Phe  Glu Asn Ala Ile Tyr  Arg Lys Asp 
    1025                 1030                 1035             


Ser Asn  Gly Ile Ile Glu Ile  Cys Lys Thr Lys Tyr  Gly Lys Lys 
    1040                 1045                 1050             


Thr His  Asp Ile Glu Phe Glu  Val Tyr Glu Gln Trp  Leu Lys Asn 
    1055                 1060                 1065             


Arg Asn  Ile Ile Leu His Pro  Ile Val Thr Tyr Ile  Arg Asn Lys 
    1070                 1075                 1080             


Phe Ser  His Ser Gln Leu Pro  Leu Ala His Gln Leu  Glu Phe Asp 
    1085                 1090                 1095             


Leu Ile  Ser Ile Arg Glu Ser  Asp Ser Phe Leu Gln  Lys Tyr Glu 
    1100                 1105                 1110             


Asn Asp  Ile Pro Ile Ile Glu  Gln Tyr Thr Thr Tyr  Ser Lys Arg 
    1115                 1120                 1125             


Ile Phe  Gln Leu Tyr Asp Glu  Lys Met Ser Asp Leu  Met Glu Gln 
    1130                 1135                 1140             


Ile Ser  Ile Val 
    1145         


<210>  2286
<211>  1156
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2286

Met Glu Asn His Thr Lys Gln Thr Thr Tyr Lys Tyr Asp Glu Ile Ala 
1               5                   10                  15      


Asp Lys His Tyr Phe Ala Gly Phe Phe Asn Leu Ala Trp Asn Asn Ile 
            20                  25                  30          


Glu Ile Val Phe Lys Val Phe Leu Lys Lys Phe Lys Leu Ile Glu Asp 
        35                  40                  45              


Lys Asp Lys Lys Ile Glu Val Asn Pro Leu Ser Phe Val Asp Asn Tyr 
    50                  55                  60                  


Phe Lys Asn Glu Leu Ala Leu Ser Asp Tyr Arg Asp Arg Ile Asp Phe 
65                  70                  75                  80  


Leu Lys Gln Tyr Phe Pro Val Val Gln Tyr Leu Glu Leu Leu Val Ser 
                85                  90                  95      


Lys Asn Asn Asp Leu Glu Lys Cys Ile Gly Glu Glu Lys Glu Asn Lys 
            100                 105                 110         


Arg Arg Glu Cys Phe Arg Ala Lys Phe Lys Ser Leu Ile Arg Thr Ile 
        115                 120                 125             


Asn Glu Leu Arg Asn Tyr Tyr Thr His His Tyr His Lys Pro Ile Ile 
    130                 135                 140                 


Val Asp Glu Ala Thr Phe Glu Leu Leu Asp Glu Leu Phe Leu Thr Val 
145                 150                 155                 160 


Val Lys Glu Val Lys Arg Tyr Lys Met Lys Gly Glu Pro Ile Arg His 
                165                 170                 175     


Leu Phe Lys Lys Glu Leu Asn Asn Glu Leu Thr Ala Leu Ile Lys Leu 
            180                 185                 190         


Lys Lys Ser Glu Leu Glu Thr Arg Arg Lys Glu Gly Lys Arg Val Asn 
        195                 200                 205             


Ile Asp Pro Val Ser Ile Glu Asn Ala Val Leu Asn Asp Ala Phe Ser 
    210                 215                 220                 


His Leu Leu Phe Gly Glu Lys Gly Glu Lys Phe Tyr Gln Ser Lys Ser 
225                 230                 235                 240 


Thr Ser Ser Asn Gln Gln Ser Thr Ile Asn Ile Ser Glu Ser Gly Leu 
                245                 250                 255     


Leu Phe Leu Leu Gly Met Phe Leu His Arg Lys Glu Ser Glu Arg Leu 
            260                 265                 270         


Arg Ser Asn Ile Gln Gly Phe Lys Ala Lys Val Val Arg Asp Pro Glu 
        275                 280                 285             


Lys Pro Ile Asp Phe Lys Asn Asn Ser Leu Lys Tyr Met Ala Thr His 
    290                 295                 300                 


Trp Val Phe Asn His Leu Ala Ala Lys Pro Ile Lys Glu Arg Leu Asn 
305                 310                 315                 320 


Thr Ala Phe Gln Lys Glu Thr Leu Leu Leu Gln Ile Ala Asp Glu Leu 
                325                 330                 335     


Ser Lys Val Pro Asp Glu Val Tyr Gln Thr Phe Ser Gln Glu Lys Lys 
            340                 345                 350         


Asn Glu Phe Leu Glu Asp Ile Asn Glu Tyr Phe Lys Thr Gly Asn Asp 
        355                 360                 365             


Ile Lys Ser Phe Glu Glu Ser Arg Val Val His Pro Val Ile Arg Lys 
    370                 375                 380                 


Arg Tyr Glu Asn Lys Phe Asn Tyr Phe Val Leu Arg Phe Leu Asp Glu 
385                 390                 395                 400 


Phe Ile Asp Phe Pro Thr Leu Arg Phe Gln Ile His Leu Gly Asn Tyr 
                405                 410                 415     


Val His Asp Gln Lys Glu Lys Pro Ile Ser Gln Gly Thr His Leu Ile 
            420                 425                 430         


Thr Gln Arg Ile Ile Lys Glu Lys Ile Asn Leu Phe Gly Lys Leu Ser 
        435                 440                 445             


Glu Val Thr Asn Asn Lys Thr Asp Phe Phe Gln Lys Leu Glu Val Ala 
    450                 455                 460                 


Gly Gly Glu Thr Asn Leu Glu Met Phe Pro Glu Pro Ser Tyr Asn Phe 
465                 470                 475                 480 


Val Gly Asn Asn Ile Pro Ile Tyr Leu Asn Leu Ala Lys Ser Lys Val 
                485                 490                 495     


Glu Gly Ala Lys Glu Leu Asn Ser His Leu Ile Arg Leu Asn Asn Glu 
            500                 505                 510         


Glu Lys Lys His Gln Lys Lys Arg Thr Gly Asn Lys Pro Asp Lys Thr 
        515                 520                 525             


Ala Ile Leu Ser Glu Ile Gln Ile Ser Gly Ile Ser Tyr Gly Lys Pro 
    530                 535                 540                 


Val Ala Leu Leu Ser Leu Asn Glu Leu Pro Ala Leu Leu Tyr Glu Leu 
545                 550                 555                 560 


Leu Ile Asn Gly Lys Ser Gly Glu Glu Ile Glu Asn Ile Leu Val Glu 
                565                 570                 575     


Lys Leu Val Ala Arg Tyr Lys Thr Ile Asn Asn Phe Ser Pro Asp Asn 
            580                 585                 590         


Pro Leu Pro Thr Ser Gln Ile Ser Lys Lys Leu Arg Lys Ala Thr Ala 
        595                 600                 605             


Asn Glu Arg Ile Asp Ile Asp Lys Leu Ile Arg Ala Ile Asp Arg Glu 
    610                 615                 620                 


Ile Thr Val Ser Lys Glu Lys Ala Asn Leu Ile Ala Thr Lys Leu Arg 
625                 630                 635                 640 


Asp Trp Glu Asn Ala Lys Thr Asn Arg Lys Tyr Val Phe Thr Lys Lys 
                645                 650                 655     


Glu Leu Gly Gln Glu Ala Thr Trp Leu Ala Asp Asp Ile Lys Arg Phe 
            660                 665                 670         


Met Pro Asn Lys Ile Lys Glu Asn Trp Lys Gly Tyr Gln His Ser His 
        675                 680                 685             


Leu Gln Leu Leu Leu Thr Phe Tyr Glu Ser Arg Pro Asn Glu Ala Tyr 
    690                 695                 700                 


Ser Phe Leu Arg Glu Phe Trp Asn Leu Asp Asp Asp Thr Tyr Leu Phe 
705                 710                 715                 720 


Asn Arg Trp Leu Lys Thr Ser Phe Asn Glu Lys Ser Phe His Lys Phe 
                725                 730                 735     


Tyr Leu Lys Tyr Leu Glu Asn Arg Lys Glu Tyr Phe Glu Asn Ile Gln 
            740                 745                 750         


Gln Gln Ile Thr Ala Phe Lys Asn Gln Glu Lys Leu Leu Lys Lys Phe 
        755                 760                 765             


Ile Glu Gln Gln His Ile Trp Ser Val Phe Tyr Lys Arg Leu Tyr Ile 
    770                 775                 780                 


Val Ser Pro Ile Glu Glu Gln Lys Arg Gln Leu Leu Leu Lys Pro Leu 
785                 790                 795                 800 


Val Phe Thr Arg Gly Ile Phe Asp Pro Lys Pro Thr Tyr Ile Glu Gly 
                805                 810                 815     


Lys Glu Phe Glu Gly Asn Lys Asp Leu Phe Ala Asp Trp Tyr Gln Tyr 
            820                 825                 830         


Ile His Asp Glu Glu His Val Leu Gln Lys Phe Tyr Ser Trp Lys Arg 
        835                 840                 845             


Asp Tyr Lys Glu Leu Phe Glu Lys Phe Lys Ala Ser Asp Glu Phe Thr 
    850                 855                 860                 


Asn Asn Lys Tyr Gln Leu Ser Glu Lys Gln Gln Phe Glu Leu Phe Asn 
865                 870                 875                 880 


Arg Lys Trp Asp Lys Lys Ile Arg Lys Ile Ile Gly Gln Asp Leu Phe 
                885                 890                 895     


Leu Asn Leu Ile Ile Lys Arg Ile Ile Lys Glu Leu Tyr His Gln Asp 
            900                 905                 910         


Val Ala Leu Asn Leu Ala Asp Tyr Tyr Leu Thr Gln Glu Glu Arg Ile 
        915                 920                 925             


Glu Lys Glu Gln Arg Ala Lys Gln Gln Thr Asn Arg Leu Lys Gly Asp 
    930                 935                 940                 


Lys Ser Glu Asn Ile Ile Asn Asp Ser Phe Ile Trp Asn Met Thr Ile 
945                 950                 955                 960 


Ser Tyr Lys Thr Asp Tyr Ile Asp Glu Pro Ala Ile Lys Leu Lys Asp 
                965                 970                 975     


Ile Gly Lys Phe Ile Arg Phe Leu Asn Asp Glu Lys Val Glu Arg Ile 
            980                 985                 990         


Phe Ser Tyr Thr Pro Lys Lys Asn  Asn Trp Arg Lys Asp  Lys Ile Glu 
        995                 1000                 1005             


Lys Glu  Leu Glu Met Tyr Glu  Lys Ile Arg Arg Glu  Glu Val Phe 
    1010                 1015                 1020             


Lys Met  Ile Gln Glu Leu Glu  Lys Lys Ile Leu Glu  Lys His Lys 
    1025                 1030                 1035             


Phe Asp  Gly Ile Asn His Pro  Asp Glu Phe Glu Lys  Ser Gly Asn 
    1040                 1045                 1050             


Pro Asn  Phe Lys Lys Tyr Ile  Ala Gln Gly Val Leu  Lys Lys His 
    1055                 1060                 1065             


Gly Ile  Gln Asp Val Val Ile  Glu Trp Ile Glu Asn  Leu Gly Glu 
    1070                 1075                 1080             


Asn Ser  Tyr Glu Asp Asn Asn  Thr Leu Glu Leu Leu  Val Gln Lys 
    1085                 1090                 1095             


Asp Lys  Lys Val Gln Asp Ala  Phe Leu Leu Ile Tyr  Leu Arg Asn 
    1100                 1105                 1110             


Lys Phe  Ala His Asn Gln Leu  Pro Thr Lys Glu Ile  Phe Asp Ile 
    1115                 1120                 1125             


Ile Val  Ser Lys Thr Asp Thr  Lys Ser Tyr Val Ala  Glu Thr Leu 
    1130                 1135                 1140             


Leu Asn  Tyr Ile Ser Ile Thr  Ser Arg Arg Ile Leu  Asn 
    1145                 1150                 1155     


<210>  2287
<211>  948
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2287

Leu Phe Phe Ser Phe His Asn Ala Gln Arg Val Ile Phe Lys His Leu 
1               5                   10                  15      


Tyr Lys Ala Phe Asp Ala Ser Leu Arg Met Val Lys Glu Asp Tyr Lys 
            20                  25                  30          


Ala His Phe Thr Val Asn Leu Thr Arg Asp Phe Ala His Leu Asn Arg 
        35                  40                  45              


Lys Gly Lys Asn Lys Gln Asp Asn Pro Asp Phe Asn Arg Tyr Arg Phe 
    50                  55                  60                  


Glu Lys Asp Gly Phe Phe Thr Glu Ser Gly Leu Leu Phe Phe Thr Asn 
65                  70                  75                  80  


Leu Phe Leu Asp Lys Arg Asp Ala Tyr Trp Met Leu Lys Lys Val Ser 
                85                  90                  95      


Gly Phe Lys Ala Ser His Lys Gln Arg Glu Lys Met Thr Thr Glu Val 
            100                 105                 110         


Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu Glu Ser Arg 
        115                 120                 125             


Tyr Asp His Asn Gln Met Leu Leu Asp Met Leu Ser Glu Leu Ser Arg 
    130                 135                 140                 


Cys Pro Lys Leu Leu Tyr Glu Lys Leu Ser Glu Glu Asn Lys Lys His 
145                 150                 155                 160 


Phe Gln Val Glu Ala Asp Gly Phe Leu Asp Glu Ile Glu Glu Glu Gln 
                165                 170                 175     


Asn Pro Phe Lys Asp Thr Leu Ile Arg His Gln Asp Arg Phe Pro Tyr 
            180                 185                 190         


Phe Ala Leu Arg Tyr Leu Asp Leu Asn Glu Ser Phe Lys Ser Ile Arg 
        195                 200                 205             


Phe Gln Val Asp Leu Gly Thr Tyr His Tyr Cys Ile Tyr Asp Lys Lys 
    210                 215                 220                 


Ile Gly Asp Glu Gln Glu Lys Arg His Leu Thr Arg Thr Leu Leu Ser 
225                 230                 235                 240 


Phe Gly Arg Leu Gln Asp Phe Thr Glu Ile Asn Arg Pro Gln Glu Trp 
                245                 250                 255     


Lys Ala Leu Thr Lys Asp Leu Asp Tyr Lys Glu Thr Ser Asn Gln Pro 
            260                 265                 270         


Phe Ile Ser Lys Thr Thr Pro His Tyr His Ile Thr Asp Asn Lys Ile 
        275                 280                 285             


Gly Phe Arg Leu Gly Thr Ser Lys Glu Leu Tyr Pro Ser Leu Glu Ile 
    290                 295                 300                 


Lys Asp Gly Ala Asn Arg Ile Ala Lys Tyr Pro Tyr Asn Ser Gly Phe 
305                 310                 315                 320 


Val Ala His Ala Phe Ile Ser Val His Glu Leu Leu Pro Leu Met Phe 
                325                 330                 335     


Tyr Gln His Leu Thr Gly Lys Ser Glu Asp Leu Leu Lys Glu Thr Val 
            340                 345                 350         


Arg His Ile Gln Arg Ile Tyr Lys Asp Phe Glu Glu Glu Arg Ile Asn 
        355                 360                 365             


Thr Ile Glu Asp Leu Glu Lys Ala Asn Gln Gly Arg Leu Pro Leu Gly 
    370                 375                 380                 


Ala Phe Pro Lys Gln Met Leu Gly Leu Leu Gln Asn Lys Gln Pro Asp 
385                 390                 395                 400 


Leu Ser Glu Lys Ala Lys Ile Lys Ile Glu Lys Leu Ile Ala Glu Thr 
                405                 410                 415     


Lys Leu Leu Ser His Arg Leu Asn Thr Lys Leu Lys Ser Ser Pro Lys 
            420                 425                 430         


Leu Gly Lys Arg Arg Glu Lys Leu Ile Lys Thr Gly Val Leu Ala Asp 
        435                 440                 445             


Trp Leu Val Lys Asp Phe Met Arg Phe Gln Pro Val Ala Tyr Asp Ala 
    450                 455                 460                 


Gln Asn Gln Pro Ile Lys Ser Ser Lys Ala Asn Ser Thr Glu Phe Trp 
465                 470                 475                 480 


Phe Ile Arg Arg Ala Leu Ala Leu Tyr Gly Gly Glu Lys Asn Arg Leu 
                485                 490                 495     


Glu Gly Tyr Phe Lys Gln Thr Asn Leu Ile Gly Asn Thr Asn Pro His 
            500                 505                 510         


Pro Phe Leu Asn Lys Phe Asn Trp Lys Ala Cys Arg Asn Leu Val Asp 
        515                 520                 525             


Phe Tyr Gln Gln Tyr Leu Glu Gln Arg Glu Lys Phe Leu Glu Ala Ile 
    530                 535                 540                 


Lys Asn Gln Pro Trp Glu Pro Tyr Gln Tyr Cys Leu Leu Leu Lys Ile 
545                 550                 555                 560 


Pro Lys Glu Asn Arg Lys Asn Leu Val Lys Gly Trp Glu Gln Gly Gly 
                565                 570                 575     


Ile Ser Leu Pro Arg Gly Leu Phe Thr Glu Ala Ile Arg Glu Thr Leu 
            580                 585                 590         


Ser Glu Asp Leu Met Leu Ser Lys Pro Ile Arg Lys Glu Ile Lys Lys 
        595                 600                 605             


His Gly Arg Val Gly Phe Ile Ser Arg Ala Ile Thr Leu Tyr Phe Lys 
    610                 615                 620                 


Glu Lys Tyr Gln Asp Lys His Gln Ser Phe Tyr Asn Leu Ser Tyr Lys 
625                 630                 635                 640 


Leu Glu Ala Lys Ala Pro Leu Leu Lys Arg Glu Glu His Tyr Glu Tyr 
                645                 650                 655     


Trp Gln Gln Asn Lys Pro Gln Ser Pro Thr Glu Ser Gln Arg Leu Glu 
            660                 665                 670         


Leu His Thr Ser Asp Arg Trp Lys Asp Tyr Leu Leu Tyr Lys Arg Trp 
        675                 680                 685             


Gln His Leu Glu Lys Lys Leu Arg Leu Tyr Arg Asn Gln Asp Val Met 
    690                 695                 700                 


Leu Trp Leu Met Thr Leu Glu Leu Thr Lys Asn His Phe Lys Glu Leu 
705                 710                 715                 720 


Asn Leu Asn Tyr His Gln Leu Lys Leu Glu Asn Leu Ala Val Asn Val 
                725                 730                 735     


Gln Glu Ala Asp Ala Lys Leu Asn Pro Leu Asn Gln Thr Leu Pro Met 
            740                 745                 750         


Val Leu Pro Val Lys Val Tyr Pro Ala Thr Ala Phe Gly Glu Val Gln 
        755                 760                 765             


Tyr His Lys Thr Pro Ile Arg Thr Val Tyr Ile Arg Glu Glu His Thr 
    770                 775                 780                 


Lys Ala Leu Lys Met Gly Asn Phe Lys Ala Leu Val Lys Asp Arg Arg 
785                 790                 795                 800 


Leu Asn Gly Leu Phe Ser Phe Ile Lys Glu Glu Asn Asp Thr Gln Lys 
                805                 810                 815     


His Pro Ile Ser Gln Leu Arg Leu Arg Arg Glu Leu Glu Ile Tyr Gln 
            820                 825                 830         


Ser Leu Arg Val Asp Ala Phe Lys Glu Thr Leu Ser Leu Glu Glu Lys 
        835                 840                 845             


Leu Leu Asn Lys His Thr Ser Leu Ser Ser Leu Glu Asn Glu Phe Arg 
    850                 855                 860                 


Ala Leu Leu Glu Glu Trp Lys Lys Glu Tyr Ala Ala Ser Ser Met Val 
865                 870                 875                 880 


Thr Asp Glu His Ile Ala Phe Ile Ala Ser Val Arg Asn Ala Phe Cys 
                885                 890                 895     


His Asn Gln Tyr Pro Phe Tyr Lys Glu Ala Leu His Ala Pro Ile Pro 
            900                 905                 910         


Leu Phe Thr Val Ala Gln Pro Thr Thr Glu Glu Lys Asp Gly Leu Gly 
        915                 920                 925             


Ile Ala Glu Ala Leu Leu Lys Val Leu Arg Glu Tyr Cys Glu Ile Val 
    930                 935                 940                 


Lys Ser Gln Ile 
945             


<210>  2288
<211>  1124
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2288

Met Lys Ile Pro Gln Ile Ile Glu Asn Asn Lys His Leu Phe Gly Ala 
1               5                   10                  15      


Tyr Ser Thr Met Ala Leu Ser Asn Ile Arg Asn Ile Leu Asp His Ile 
            20                  25                  30          


Ala Thr Leu Ala Asp Ile Glu Asn Asp Phe Tyr Ser Asp Ser Asp Ser 
        35                  40                  45              


Tyr Trp Tyr His Pro Cys Ile Lys Ile Ile Asp Pro Arg Asn Asn Cys 
    50                  55                  60                  


Thr Asp Ala Ala Lys Ala Asp Phe Val Ile Glu Lys Ile Lys Ser His 
65                  70                  75                  80  


Phe Pro Phe Val Pro Ile Val Ala Glu Ala Gln Arg Gln Ser Asp Ile 
                85                  90                  95      


Leu Arg Ala Lys Lys Gln Leu Asp Ile Ala Val Arg Asn Arg Asp Tyr 
            100                 105                 110         


Gln Lys Gln Glu Glu Leu Lys His Arg Gln Lys Ser Leu Leu Ser Val 
        115                 120                 125             


Thr Asn Ala Asp Ile Tyr Arg Val Leu Asn Asn Met Leu Trp Val Leu 
    130                 135                 140                 


Ala Asn Tyr Arg Asn Gln Thr Val His Tyr Leu Ile Ser Asp Ile Lys 
145                 150                 155                 160 


Phe Glu Asp Gly Ser Asp Phe Leu Asn Tyr Asn Glu Gln Pro Leu Ser 
                165                 170                 175     


Arg Met Leu Asn Asn Tyr Phe Thr Ile Ala Leu Arg Asp Thr Ala Asn 
            180                 185                 190         


Lys Tyr Ser Tyr Ser Pro Glu Ala Leu Ser Phe Ile Gln Ser Ser Arg 
        195                 200                 205             


Tyr Lys Thr Glu Asn Arg Arg Lys Ile Leu Asp Thr Asp Phe Phe Leu 
    210                 215                 220                 


Ser Ile Gln His Asn Asn Ser Asp Thr Asn Pro Lys Asn Leu His Leu 
225                 230                 235                 240 


Ser Gly Val Gly Val Ala Leu Leu Ile Cys Leu Phe Leu Glu Lys Lys 
                245                 250                 255     


Tyr Val Asn Val Phe Leu Gln Lys Leu Pro Ile Tyr Gly Pro Tyr Lys 
            260                 265                 270         


Lys Gln Ser Met Glu Ala Asn Ile Ile Arg Gln Ser Phe Ser Ile His 
        275                 280                 285             


Thr Val Lys Leu Pro Lys Glu Arg Ile Val Ser Glu Lys Ser Asp Phe 
    290                 295                 300                 


Thr Ile Ala Leu Asp Met Leu Asn Glu Leu Lys Arg Cys Pro Lys Gln 
305                 310                 315                 320 


Leu Phe Ser Thr Leu Ser Tyr Ala Asp Gln Asn Ala Phe Arg Ile Val 
                325                 330                 335     


Ser Ser Asp Met Ser Asp Val Leu Gln Val Arg His Thr Asp Arg Phe 
            340                 345                 350         


Ala Gln Leu Ser Leu Glu Tyr Ile Asp Arg Arg Glu Leu Phe Ser Asp 
        355                 360                 365             


Ile Arg Phe His Leu Asn Met Gly Lys Leu Arg Tyr Leu Lys Thr Ala 
    370                 375                 380                 


Asp Lys His Cys Ile Asp Gly Val Ser Arg Val Arg Val Leu Glu Gly 
385                 390                 395                 400 


Lys Ile Asn Ala Phe Gly Arg Ile His Glu Phe Glu Ala Arg Arg Lys 
                405                 410                 415     


Glu Gln Gly Phe Val Glu Trp His Glu Gln Ala Ala Arg Leu Ile Lys 
            420                 425                 430         


Thr Asn Lys Asn Ile Glu Ile Arg Asp Phe Glu His Val Lys Arg Asp 
        435                 440                 445             


Asp Ala Thr Pro Asp Ser Tyr Pro Tyr Ile Ile Asp Thr Tyr Thr His 
    450                 455                 460                 


Tyr Leu Leu Glu Asn Asn Lys Ile Glu Met Arg Phe Gly Asp Tyr Leu 
465                 470                 475                 480 


Pro Lys Leu Val Lys Val Asp Asp Gln Lys Trp Thr Val Tyr Asn Glu 
                485                 490                 495     


Met Pro Thr Cys Cys Met Ser Ala Leu Glu Leu Pro Ala Met Met Phe 
            500                 505                 510         


His Met Met Leu Cys Gly Ser Glu Ala Thr Glu His Leu Ile Lys Ala 
        515                 520                 525             


Glu Val Glu Lys Tyr Lys Lys Leu Phe Gly Ala Met Ala Asn Gly Thr 
    530                 535                 540                 


Leu Ser Lys Glu Asn Ile Gly Asn Phe Glu Ile Ala Met Glu Asp Leu 
545                 550                 555                 560 


Pro Lys Lys Val Ile Asp Cys Val Asn Arg Lys Lys Ser Gly Lys Ser 
                565                 570                 575     


Phe Val Lys Gln Ile Lys Lys Glu Ile Ala Glu Met Leu Ala Asp Thr 
            580                 585                 590         


Asn Leu Arg Ile Val Arg Leu Lys Ser Asp Lys Arg Ser Val Ala Ser 
        595                 600                 605             


Thr Gln Asn Lys Met Gly Lys Arg Gly Phe Arg Ser Ile Gln Pro Gly 
    610                 615                 620                 


Lys Leu Ala Asp Trp Leu Ala Ala Asp Ile Val Lys His Gln Pro Ser 
625                 630                 635                 640 


Leu Phe Ser Gly Asp Asp Tyr Gly Thr Asp Arg Ile Thr Gly Met Asn 
                645                 650                 655     


Tyr Arg Val Met Gln Ser Thr Ile Ala Thr Phe Asn Ala Ala Thr Pro 
            660                 665                 670         


Glu His Ser Leu Asp Glu Leu Lys Arg Val Phe Ser Ala Ala Gln Leu 
        675                 680                 685             


Ile Gln Cys Gln Glu Arg Glu His Pro Phe Leu Gln Lys Ala Leu Asn 
    690                 695                 700                 


Arg Asn Pro Gln Asn Thr Ile Asp Phe Tyr Glu Phe Tyr Leu Gln Ala 
705                 710                 715                 720 


Lys Arg Ala Tyr Tyr Gln Ser Leu Arg Gln Ser Ile Glu Asn Gly Glu 
                725                 730                 735     


Asp Val Lys Leu Pro Tyr Leu Asn Pro Asp Arg Asn Lys Trp Val Arg 
            740                 745                 750         


Arg Gly Ala Ser Phe Tyr Ser Thr Met Gly Asp Ile Tyr Leu Glu Asp 
        755                 760                 765             


Met Pro Ile Glu Leu Pro Arg Gln Met Phe Asp Lys Glu Ile Lys Lys 
    770                 775                 780                 


Ala Leu Ala Gln Leu Pro Ser Met Lys Gly Val Asp Met Lys Gln Ser 
785                 790                 795                 800 


Asn Val Thr Phe Leu Ile Ala Glu Tyr Leu Lys Arg Glu Leu Lys Asp 
                805                 810                 815     


Asp Phe Gln Pro Phe Tyr Gln Trp Asn Arg Asn Tyr Arg Phe Thr Asp 
            820                 825                 830         


Met Met Ile Cys Glu Glu Asn Cys Asp Thr Lys Ala Leu Ala Ser Lys 
        835                 840                 845             


Phe Ile Pro Leu Glu Leu Arg Glu Glu Ile Trp Glu Lys Arg Gly Glu 
    850                 855                 860                 


Leu Lys Asp Ala Tyr Lys Arg Trp Ala Phe Gly Arg Leu Asn Lys Asn 
865                 870                 875                 880 


Pro Asp Ile Lys Arg Leu Ser Pro Ala Glu Lys Asp Glu Leu Leu Glu 
                885                 890                 895     


Lys Arg Ile Ala Lys Cys Arg Asn Glu Tyr Gln Lys Ser Glu Lys Ile 
            900                 905                 910         


Ile Arg Arg Tyr Lys Val Gln Asp Val Leu Met Phe Met Met Val Lys 
        915                 920                 925             


Ser Met Phe Ala Gln Gly Val Phe Thr Ala Glu Ser Lys Glu Phe Ala 
    930                 935                 940                 


Leu Ser Thr Ile Thr Pro Asp Ala Glu Arg Gly Ile Leu Ser Glu Val 
945                 950                 955                 960 


Val Pro Ile Asp Phe Lys Phe Ser Ile Asp Gly Lys Thr Tyr Thr Ile 
                965                 970                 975     


His Ser Asn Gly Met Lys Ile Lys Asn Tyr Gly Asp Phe Tyr Lys Leu 
            980                 985                 990         


Ile Asn Asp Lys Arg Met Lys Ser  Leu Leu Asn Ile Val  Thr His Ser 
        995                 1000                 1005             


Thr Ile  Glu Lys Asp Leu Leu  Glu Lys Glu Phe Ser  Thr Tyr Asp 
    1010                 1015                 1020             


Asp Lys  Arg Pro Glu Ala Val  Glu Ile Ile Phe Glu  Phe Glu Lys 
    1025                 1030                 1035             


Ala Ala  Tyr Glu Lys His Pro  Glu Leu Lys Glu Leu  Leu Thr Pro 
    1040                 1045                 1050             


Glu Arg  Lys Phe Asp Phe Arg  Ala Leu Leu Glu Glu  Leu Gln Ala 
    1055                 1060                 1065             


Lys Ser  Asp Leu Ser Gln Ile  Asp Ala Arg Tyr Leu  Ser Gln Ile 
    1070                 1075                 1080             


Arg Asn  Ala Phe Asn His Asn  Ala Tyr Pro Arg Asn  Leu Lys Ile 
    1085                 1090                 1095             


Thr Ser  Asn Ile Pro Glu Ile  Ala Gln Glu Met Val  Asn Ile Phe 
    1100                 1105                 1110             


Arg Ile  Thr Asp Pro Tyr Lys  Lys Gly Lys Lys 
    1115                 1120                 


<210>  2289
<211>  1167
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2289

Met Glu Thr Lys Glu Gln Ile Gly Lys Asn Val Tyr Lys Thr Ser Glu 
1               5                   10                  15      


Asn Asp Pro Leu Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg His Asn 
            20                  25                  30          


Val Phe Leu Ile Ile Asn His Leu Thr Glu Val Phe Asp Ser Leu Gly 
        35                  40                  45              


Tyr Thr Lys Ile Asn Asp Asp Glu Asp Ile Val Asn Gln Asp His Ile 
    50                  55                  60                  


Leu Ser Gln Ile Phe Asp Pro Ser Lys Lys Glu Leu Glu Asn Glu Arg 
65                  70                  75                  80  


Ile Arg Ile Tyr Asn Tyr Met Ile Lys Arg His His Leu Pro Phe Leu 
                85                  90                  95      


Lys Val Phe Asn Ser Glu Ile Leu Asn Asp Glu Asp Gly Glu Asn Met 
            100                 105                 110         


Gly Ile Asp Phe Lys Ser Leu His Asn Phe Ile Ile Lys Ser Phe Lys 
        115                 120                 125             


Thr Leu Asn Asp Leu Arg Asn Ser Tyr Ser His Tyr Leu Ala Ile Asp 
    130                 135                 140                 


Asp Asp Gly Asn Lys Ile Glu Lys Arg Ser Asn Ile Val Asp Val Ser 
145                 150                 155                 160 


Ile Lys Ser Asp Ile Lys Gln Leu Phe Lys His Ala Pro Lys Phe Ser 
                165                 170                 175     


Phe Ile Arg Asn Gln Glu Thr Gln His Glu Glu Asp Tyr Asn His Leu 
            180                 185                 190         


Asp Arg Tyr Arg Ile Phe Glu Asn Glu Thr Asn Ile Leu Thr Asp Gln 
        195                 200                 205             


Gly Leu Tyr Phe Phe Ile Asn Leu Phe Leu Glu Arg Asn His Ala Thr 
    210                 215                 220                 


Lys Phe Leu Lys Lys Ile Lys Gly Phe Lys Asn Glu Thr Thr Pro Pro 
225                 230                 235                 240 


Phe Arg Ala Thr Ile Gln Ser Phe Thr Ser Phe Ala Leu Lys Leu Pro 
                245                 250                 255     


Asp Ile Arg Leu Ser Asn Glu Arg Pro Leu Phe Ser Leu Leu Met Asn 
            260                 265                 270         


Met Leu Thr Glu Leu Asn Lys Cys Pro Lys Glu Leu Phe Asn His Leu 
        275                 280                 285             


Thr Gln Lys Asp Lys Lys Glu Phe Glu Pro Leu Leu Asn Asp Glu Glu 
    290                 295                 300                 


Lys His Asn Val Val Leu Asn Ser Thr Asn Tyr Ser Glu Ile Ser Asp 
305                 310                 315                 320 


Asp Glu Leu Asp Glu Ala Ile Arg Glu Ile Thr Ala Leu Lys Arg Tyr 
                325                 330                 335     


Asn Asp Arg Phe Pro Tyr Phe Ala Leu Arg Phe Leu Asp Glu Thr Asn 
            340                 345                 350         


Ala Leu Lys Asn Ile Arg Phe Gln Ile Thr Leu Gly Lys Leu Ile Ile 
        355                 360                 365             


Lys Arg Tyr Asp Lys Glu Ile Ala Gly Ile Glu Glu Asn Arg Arg Val 
    370                 375                 380                 


Ile Lys Thr Ile Asn Ala Phe Gly Lys Leu Ser Asp Phe Ile Asp Asn 
385                 390                 395                 400 


Glu Glu Val Val Leu Lys Glu Leu Lys Lys Asn Leu Ala Asp Asn Asn 
                405                 410                 415     


Asp Ile Arg Phe Glu Gln Tyr Ser Pro His Tyr Asn Thr Asn Asn Ile 
            420                 425                 430         


Lys Ile Ala Phe Tyr Val Phe Asp Glu Gly Asp Asp Lys Thr Lys Tyr 
        435                 440                 445             


Pro Phe Val Phe Glu Asn Lys Glu Asn Asn Ser Asp Ile Gln Asn Asn 
    450                 455                 460                 


Pro Ser Gly Phe Leu Ser Ile His Asp Leu Pro Lys Met Leu Leu Phe 
465                 470                 475                 480 


Glu Cys Leu Asp Ile Asn Leu Lys Pro Glu Asn Ile Ile Ile Asp Phe 
                485                 490                 495     


Ile Arg Ser Thr Asn Leu Glu Met Phe Asp Leu Ser Glu Leu Glu Lys 
            500                 505                 510         


Ile Arg Lys Gln Ala Asn Tyr Glu Pro Glu Tyr Phe Ser Lys Arg Ile 
        515                 520                 525             


Asn Lys Glu Lys Tyr Leu Ile Ser Lys Lys Gly Ile Lys Tyr Leu Ser 
    530                 535                 540                 


Lys Glu Val Glu Asn Asn Met Leu Glu Asp Leu Gly Leu Ser Lys Asp 
545                 550                 555                 560 


Glu Leu Ile Leu Lys Asp Lys Asp Ser Phe Met Lys Leu Thr Asn Ser 
                565                 570                 575     


Lys Lys Tyr Ile Glu Tyr Phe Ser Gln Ile Lys Tyr Gln Tyr Tyr Leu 
            580                 585                 590         


Gln Lys Arg Arg Glu Glu Leu Gln Arg His Leu Pro Lys Gly Leu Lys 
        595                 600                 605             


Ile Asp Leu Leu Pro Glu Asn Ile Leu Glu Tyr Leu Met Asp Phe Lys 
    610                 615                 620                 


Glu Arg Asn Asn Glu Gly Ile Ile His Gln Lys Val Ala Ala Ile Arg 
625                 630                 635                 640 


Asp Glu Ala Lys Asn Leu Lys Lys Ser Ile Glu Ser Glu Val Glu Lys 
                645                 650                 655     


Pro Lys Asn Glu Gln Arg Ile Lys Leu Gly Glu Leu Ala Thr Phe Val 
            660                 665                 670         


Ala Arg Asp Ile Ile Lys Met Val Ile Cys Lys Glu Val Lys Asp Lys 
        675                 680                 685             


Ile Thr Ser Pro Tyr Tyr Asn Lys Leu Gln Asn Lys Ile Ala Tyr Phe 
    690                 695                 700                 


Ser Leu Asn Lys Asp Glu Leu Ile Asp Ile Cys Asp Glu Leu Lys Leu 
705                 710                 715                 720 


Phe Asn Glu Asn Glu Gly His Val Phe Phe Lys Lys Glu Leu Ile Lys 
                725                 730                 735     


Asn Ser Asp Gly Ile Ile Asp Phe Thr Leu Asp Tyr Leu Arg Ala Lys 
            740                 745                 750         


Asp Asn Trp Ile Glu Thr Lys Leu Leu Lys Lys Gly Lys Thr Gly Gly 
        755                 760                 765             


Tyr Arg Phe Pro Asp Lys Thr Lys Ile Pro Leu Ser Phe Asn Lys Ile 
    770                 775                 780                 


Lys Asn Lys Ala Asn Ser Phe Asp Phe Lys Thr Trp Leu Lys Asn Lys 
785                 790                 795                 800 


Ser Gln Leu Pro Val Asp Leu Pro Arg Ser Leu Phe Asp Glu Lys Leu 
                805                 810                 815     


Glu Ile Ile Leu Lys Gly Lys Leu Asn Gln Lys Gly Ile Ile Phe Asn 
            820                 825                 830         


Thr Gly Asp Lys Phe Ser Val Leu Leu Ser Lys Tyr Leu Asn Asn Asp 
        835                 840                 845             


Thr Gln Val Phe Tyr Asn Tyr Cys Arg Ser Tyr Ser Ile Asn Lys Lys 
    850                 855                 860                 


Ile Glu Glu Phe Glu Ile Ser Gly Leu Ser Gly Lys Glu Ile Lys Lys 
865                 870                 875                 880 


Asn Phe Asp Ser Asn Val Glu Lys Asn Glu Lys Ser Ile Arg Phe Ile 
                885                 890                 895     


Gln Thr Lys Asp Arg Val Leu Lys Leu Ile Ser Asp Lys Ile Leu Ser 
            900                 905                 910         


Ile Asp Arg Ser Ile Gly Leu Gln Ser Gly Phe Cys Leu Thr Asp Ile 
        915                 920                 925             


His Pro Ala Ala Lys His Asn Pro Leu Asp Cys Pro Ala Val Phe Glu 
    930                 935                 940                 


Gln Lys Ile Ile Arg Arg Gly Asp Glu Val Phe Cys Asn Ile Ile Ala 
945                 950                 955                 960 


Lys Asp Thr Glu Asn Gln Ile Gln Ser Val Lys His Phe Glu Ser Leu 
                965                 970                 975     


Gln Ala Glu Glu Glu Lys Glu Ala Tyr Pro Asp Gln Lys Trp Tyr Gln 
            980                 985                 990         


Trp Thr Ile Lys Asp Phe Gly Arg  Phe Lys Arg Phe Ile  Lys Asp Arg 
        995                 1000                 1005             


Arg Ile  Pro Asn Leu Ser Asn  Tyr Phe Glu Asp Lys  Asn Ile Pro 
    1010                 1015                 1020             


Phe Asp  Leu Leu Glu Tyr Gln  Leu Arg Glu Tyr Asn  Lys Tyr Lys 
    1025                 1030                 1035             


Glu Glu  Ile Phe Glu Leu Thr  Leu Met Leu Glu Lys  Glu Ile Ile 
    1040                 1045                 1050             


Asn Tyr  Asp Phe Glu Gly Ile  Arg Thr Ile Glu Phe  Ser Glu Asn 
    1055                 1060                 1065             


Arg Arg  Pro Lys Gly Phe Tyr  Glu Ile Arg Phe Asp  Thr Tyr Met 
    1070                 1075                 1080             


Glu Trp  Leu Asp Asn Lys Asn  Ile Gln Tyr Asn Lys  Glu Arg Val 
    1085                 1090                 1095             


Lys Glu  Cys Arg Asn Lys Phe  Ser His Ser Glu Tyr  Pro Leu Phe 
    1100                 1105                 1110             


Lys Glu  Ile Ser Lys Ile Ser  Lys Gln Gln Ile Thr  Glu Phe Glu 
    1115                 1120                 1125             


Thr Asn  Lys Gln Ile Lys Asp  Tyr Lys Ser Ser Ser  Gly Ile Ser 
    1130                 1135                 1140             


Ile Ala  Glu Lys Ile Tyr Asn  Leu Tyr Lys Leu Glu  Ile Glu Arg 
    1145                 1150                 1155             


Ile Ile  Asn Ser Ile Lys Asn  Asn Ile 
    1160                 1165         


<210>  2290
<211>  1160
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2290

Met Glu Thr Gln Glu Gln Ile Ala Lys Asn Ile Tyr Tyr Ala His Asp 
1               5                   10                  15      


Ile Tyr Glu Asp Lys His Tyr Phe Gly Ala Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Gly Gln Val Phe Ser Glu Phe Cys Thr Arg Leu Asn Glu 
        35                  40                  45              


Pro Lys Asp Glu Asn Val His Asn Ile Ile Ile Lys Tyr Phe Ser Asn 
    50                  55                  60                  


Asn Val Ser Tyr Ser Asp Trp Asp Lys Arg Ile Lys Ile Leu Lys Glu 
65                  70                  75                  80  


Tyr Leu Pro Val Ile Glu His Leu Asn Leu Pro Thr Ser Asp Asn Ile 
                85                  90                  95      


Phe Glu Glu Tyr Gln Ile Asn Glu Lys Glu Asn Lys Lys Arg Asp Tyr 
            100                 105                 110         


Phe Arg Lys Asn Phe Gln Ser Leu Ile Lys Ser Val Asn Asp Leu Arg 
        115                 120                 125             


Asn Phe Tyr Thr His Tyr Tyr His Pro Pro Val Val Ile Asp Glu Ser 
    130                 135                 140                 


Leu Phe Asp Phe Leu Asp Ser Leu Leu Leu Lys Thr Cys Leu Thr Val 
145                 150                 155                 160 


Arg Lys Lys Lys Met Lys Asn Asp Lys Thr Arg Gln Ile Leu Lys Lys 
                165                 170                 175     


Gly Ile Ile Ala Glu Trp Lys Val Leu Glu Glu Leu Lys Val Asn Glu 
            180                 185                 190         


Leu Lys Lys Asn Lys Glu Lys Asn Lys Trp Ile Asn Ile Asp Asp Lys 
        195                 200                 205             


Glu Gly Ile Arg Asn Ala Ile Leu Asn Asp Ser Phe His His Leu Ile 
    210                 215                 220                 


Phe Lys Asp Lys Asp Ser Phe Cys Leu Lys Asp Tyr His Lys Ala Lys 
225                 230                 235                 240 


Tyr Ser Lys Asn Ile Phe Ala Glu Asn Lys Ile Pro Ile Ser Lys Ser 
                245                 250                 255     


Gly Leu Val Phe Leu Leu Ser Leu Phe Leu Thr Lys Lys Glu Thr Glu 
            260                 265                 270         


Gln Leu Lys Ala Asn Ile Glu Gly Phe Lys Ala Lys Val Ile Gly Lys 
        275                 280                 285             


Glu Asp Glu Val Thr Lys Lys Asn Asn Ser Leu Lys Tyr Met Ala Thr 
    290                 295                 300                 


His Trp Val Phe Ser Tyr Leu Thr Tyr Lys Gly Leu Lys Arg Arg Val 
305                 310                 315                 320 


Ser Thr Ser Phe Asp Lys Val Thr Leu Leu Thr Gln Met Leu Asp Glu 
                325                 330                 335     


Leu Ser Lys Val Pro Asp Glu Val Tyr Gln Thr Phe Ser Ile Ser Asp 
            340                 345                 350         


Lys Asp Glu Phe Leu Glu Asp Ile Asn Glu Phe Val Gln Glu Ser Thr 
        355                 360                 365             


Gly Asp Asp Lys Ser Leu Ile Glu Ser Thr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Asn Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu 
385                 390                 395                 400 


Asp Glu Tyr Ala Asn Phe Pro Thr Leu Lys Phe Gln Ile Phe Ala Gly 
                405                 410                 415     


Leu Phe Gln His Asp His Lys Thr Lys Asn Ile Gly Glu Ser Asn Tyr 
            420                 425                 430         


Ile Ser Asp Arg Gln Ile Lys Glu Lys Ile Asn Val Phe Gly Lys Leu 
        435                 440                 445             


Ser Lys Val Ala Lys Tyr Lys Ser Asp Tyr Phe Thr Glu Asn Glu Asn 
    450                 455                 460                 


Glu Asn Glu Trp His Leu Phe Pro Asn Pro Ser Tyr Asn Phe Val Gly 
465                 470                 475                 480 


Asn Asn Ile His Ile Tyr Phe Asp Met Tyr Arg Lys Gly Ala Glu Val 
                485                 490                 495     


Lys Ser Val Gln Glu Glu Ile Asn Ala Leu Arg Lys Ile Ile Asn Pro 
            500                 505                 510         


Lys Lys Asp Arg Val Asn Arg Lys Gly Lys Lys Glu Ile Ile Asp Met 
        515                 520                 525             


Ile Tyr Asn Lys Ser Ser Lys Ile Glu Tyr Asn Glu Pro Thr Ala Leu 
    530                 535                 540                 


Phe Ser Leu Asn Glu Leu Pro Ala Ile Leu Tyr Glu Phe Leu Ile Asn 
545                 550                 555                 560 


Lys Lys Thr Gly Glu Asp Leu Glu Asn Ile Leu Val Gln Lys Ile Val 
                565                 570                 575     


Glu Arg Tyr Lys Thr Ile Lys Asn Tyr Asn Thr Thr Gln Gln Leu Ser 
            580                 585                 590         


Asn Ser Phe Ile Thr Lys Lys Leu Arg Lys Ser Ser Leu Lys Gln Asp 
        595                 600                 605             


Gln Ile Asn Ile Glu Lys Leu Leu Arg Ser Ile Asn Lys Glu Ile Glu 
    610                 615                 620                 


Ile Asn Gly Glu Lys Leu Asn Leu Ile Lys Thr Asn Lys Glu Glu Thr 
625                 630                 635                 640 


Thr Lys Thr Asn Lys Gln Asp Lys Pro Glu Arg Lys Tyr Ile Phe Tyr 
                645                 650                 655     


Thr Asn Glu Leu Gly Gln Glu Ala Thr Trp Leu Ala Asn Asp Leu Val 
            660                 665                 670         


Arg Phe Met Pro Lys Phe Ala Lys Thr Asn Trp Lys Gly Tyr Gln His 
        675                 680                 685             


Ser Glu Leu Gln Arg Leu Leu Ala Phe Tyr Asp Arg His Lys Asn Glu 
    690                 695                 700                 


Ala Lys Thr Leu Leu Thr Thr Asn Trp Asp Leu Asn Ser Phe Pro Ile 
705                 710                 715                 720 


Trp Gly Ser Asp Ile Asn Glu Ala Phe Asp Lys Asp Lys Phe Asp Glu 
                725                 730                 735     


Phe Tyr Glu Glu Tyr Leu Lys Lys Arg Lys Lys Thr Leu Glu Gly Phe 
            740                 745                 750         


Ala Asn Thr Ile Glu Leu Asn Lys Asn Asp Pro Lys Leu Leu Lys Lys 
        755                 760                 765             


Val Leu Lys Glu Val Phe Ile Ala Phe Asp Lys Arg Leu Phe Val Ile 
    770                 775                 780                 


Ser Ser Ile Asp Lys Gln Lys Asn Glu Leu Leu Ala Lys Pro Ile Val 
785                 790                 795                 800 


Phe Pro Arg Gly Ile Phe Asp Asn Lys Pro Thr Phe Ile Leu Gly Gln 
                805                 810                 815     


Lys Val Glu Gln Ala Pro Ser Leu Tyr Ala Asp Trp Tyr Ser Tyr Cys 
            820                 825                 830         


Tyr Asp Lys Ser Leu Arg Phe Gln Lys Phe Tyr Asp Phe Asn Arg Glu 
        835                 840                 845             


Cys Thr Asp Ser Phe Glu Lys Tyr Glu Val Glu Asn Lys Glu Ser Lys 
    850                 855                 860                 


Leu Asn Lys Lys Asn Leu Ser Arg Gln Gln Lys Ile Asp Leu Phe Lys 
865                 870                 875                 880 


Lys Lys Gln Asp Leu Leu Ile Lys Lys Val Gln His Lys Asp Ile Phe 
                885                 890                 895     


Ile Lys His Met Ile Asp Tyr Leu Phe Phe Lys Val Phe Lys Lys Glu 
            900                 905                 910         


Ile Asp Ile Ser Leu Asn Glu Ile Tyr Gln Thr Lys Glu Glu Arg Leu 
        915                 920                 925             


Asn Asn Gln Ile Val Ala Ile Glu Gln Arg Asp Arg Glu Lys Gly Asp 
    930                 935                 940                 


Lys Ser Glu Asn Lys Leu Ile Asp Asn Phe Ile Trp Asn Lys Thr Ile 
945                 950                 955                 960 


Ser Met Ser Leu Leu Asn Gly Gln Ile Ile Glu Pro Asp Val Lys Leu 
                965                 970                 975     


Lys Asp Ile Gly Lys Phe Lys Lys Leu Glu Thr Asp Lys Lys Val His 
            980                 985                 990         


His Leu Leu Ser Tyr Asp Lys Thr  Lys Ile Trp Asn Lys  Leu Met Leu 
        995                 1000                 1005             


Glu Asp  Glu Leu Glu Asn Lys  Leu Asp Ser Tyr Glu  Arg Ile Arg 
    1010                 1015                 1020             


Arg Glu  Lys Leu Leu Lys Leu  Val Gln Leu Phe Glu  Lys Gly Ile 
    1025                 1030                 1035             


Ile Glu  Asn His Ser Glu Asn  Asn Asp Glu His Pro  Lys Glu Phe 
    1040                 1045                 1050             


Glu Lys  Asp Gly Lys Pro Asn  Phe Arg Lys Tyr Ile  Ala Lys Gly 
    1055                 1060                 1065             


Val Leu  Lys Lys Asn Thr Lys  Ile Ala Glu Ser Glu  Ile Asn Trp 
    1070                 1075                 1080             


Leu Ser  Asp Ile Lys Asp Met  Glu Thr Val Glu Ile  Ser Glu Val 
    1085                 1090                 1095             


Asn Ser  Lys Ser Val Ile Leu  Gln Lys Ala Tyr Thr  Leu Ile Leu 
    1100                 1105                 1110             


Leu Arg  Asn Lys Phe Gly His  Asn Gln Leu Pro Asp  Lys Asn Ala 
    1115                 1120                 1125             


Phe Asp  Met Met Gln Thr Leu  Tyr Lys Thr Ala Glu  Asn Glu Thr 
    1130                 1135                 1140             


Tyr Ser  Lys Tyr Phe Leu Arg  Val Thr Glu Gln Ile  Ile Asn Glu 
    1145                 1150                 1155             


Phe Ser  
    1160 


<210>  2291
<211>  1094
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2291

Met Glu Ala Asn Glu Gln Asn Gln Glu Asn Arg Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Asn Asn His Ile Ala Ala Asp Phe Gly Gln Ala Val 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ser Gly Phe Leu Cys Asn Lys Glu 
    50                  55                  60                  


Ile Lys Lys Leu Asn Trp Asn His Ile Tyr Ala Lys Thr Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ile Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Val Asn Ser Asp Lys Glu Gly Lys Asp Phe Ala Ala Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Ser Glu Leu Gln Asp Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Glu Asn Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Ala Glu Leu Thr Asp Met Leu Thr Ile Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Thr Asp Ala Asp Tyr 
                165                 170                 175     


Glu Leu Val Glu Thr Lys Gln Val Val Thr Thr Gly Asn Ile Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Met Phe Leu Glu Arg Glu His 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asn Leu Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Gly 
            260                 265                 270         


Val Ile Thr Asp Glu Glu Lys Met Gln Phe Arg Pro Glu Leu Asp Glu 
        275                 280                 285             


Leu Asp Ile Glu Lys Leu Ile Ala Asn Ser Thr Asn Asp Asp Glu Arg 
    290                 295                 300                 


Glu Arg Ile Leu Asp Glu Ile Gly Tyr Glu Glu Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg Tyr Asn Asn Arg Phe Pro Tyr Phe Ala Met Arg 
                325                 330                 335     


Phe Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Arg Tyr Thr Lys Gln Leu Ala Gly Glu 
        355                 360                 365             


Gln Thr Glu Arg Val Val Gln Glu Asn Val Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asp Pro Glu Leu Ile Gln Gln Lys Ile Asp Asn Gln 
385                 390                 395                 400 


Gln Arg Thr Asp Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Ile Ala Ile Leu Ile 
            420                 425                 430         


Pro Lys Ser Lys Pro Glu Ser Lys Val Gly Asn Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Asp Tyr Leu Gln Lys Gly Lys Ala Glu Glu Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Ile Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Leu Lys Leu Pro Ala Asn Trp Asn Glu Phe Ala Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asp Ala Ala Met Glu Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Asp Val Leu Ile Thr Tyr Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Asp Val Glu Asp Asn Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Leu Glu Lys His Lys Leu 
            580                 585                 590         


Asp Lys Ser Val Lys Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Met Val Ser Lys Glu Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Ala Asp Thr Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Val Leu Glu Gly Asp Gly His Pro Phe Leu Thr Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Glu Leu Tyr Met Asn 
        675                 680                 685             


Ala Lys Val Gln Tyr Leu Ile Gln Phe Tyr Lys Pro Ser Lys Asp Lys 
    690                 695                 700                 


Val Asp Lys Arg Gly Arg Pro Thr Thr Glu Val Lys Leu Pro Pro Leu 
705                 710                 715                 720 


Asp Lys Arg Ser Asn Ile Pro Phe Thr Ile Arg Gln Trp Asp Glu Lys 
                725                 730                 735     


Glu Lys Tyr Asn Leu Asn Ala Trp Leu Arg Asn Val Thr Val Gly Lys 
            740                 745                 750         


Asn Thr Lys Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe 
        755                 760                 765             


Asp Glu Thr Leu Cys Asp Leu Leu Ser Gln Gln Leu Asp Ala Arg Thr 
    770                 775                 780                 


Val Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Leu Trp 
785                 790                 795                 800 


Trp Lys Thr Arg Asp Asp Ala Thr Gln Asp Phe Tyr Gln Ser Glu Arg 
                805                 810                 815     


Glu Tyr Asp Ile Tyr Glu Glu Lys Val Glu Phe Lys Ile Asp Ser Ser 
            820                 825                 830         


Gly His Phe Ala Asp Tyr Tyr Lys Lys Ala Leu Ser Lys Ala Tyr Asn 
        835                 840                 845             


Arg Leu Lys Ala Glu Arg Glu Ile Ala Arg Arg Thr Asn Lys Arg Leu 
    850                 855                 860                 


Pro Pro Ile Glu His Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile 
865                 870                 875                 880 


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
                885                 890                 895     


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asp Ser Gly Asn Leu Lys 
            900                 905                 910         


Leu Ser Thr Ile Lys Thr Ser Leu Asn Asn Thr Thr Gln Ile Lys Gln 
        915                 920                 925             


Lys Ile Leu Asn Lys Thr Ile Val Ala Glu Arg Lys Gln Lys Asn Tyr 
    930                 935                 940                 


Thr Glu Leu Arg Lys Tyr Val His Asp Arg Arg Leu Pro Asn Leu Phe 
945                 950                 955                 960 


Glu Tyr Val Glu Ala Asp Glu Ile Leu Leu Glu Trp Leu Leu Asp Glu 
                965                 970                 975     


Leu Met Ala Tyr Asn Ala Ala Lys Gln Gln Val Phe Asp Thr Ile Phe 
            980                 985                 990         


Met Leu Glu Lys Arg Ile Ile Glu  Thr Asp Pro Gln Glu  Leu Lys Ser 
        995                 1000                 1005             


Leu Phe  Thr Asn Glu Lys Gly  Gln Val Gln Thr Gly  Asn Ile Gln 
    1010                 1015                 1020             


His Lys  Pro Tyr Val Gln Trp  Leu Lys Asn Lys Gly  Leu Ile Asn 
    1025                 1030                 1035             


His Asn  Glu Lys Leu Phe Ile  Asn Met Val Arg Asn  Cys Phe Ser 
    1040                 1045                 1050             


His Asn  Gln Phe Pro Gln Arg  Glu Thr Met Glu Leu  Leu Ile Ser 
    1055                 1060                 1065             


Glu Trp  Gly Ala Gly Lys Ile  Ala Thr Gln Ile Leu  Thr Val Tyr 
    1070                 1075                 1080             


Asn Gln  Leu Ile Thr Asn Ile  Ile Asn Lys Ile 
    1085                 1090                 


<210>  2292
<211>  950
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2292

Leu Phe Phe Ser Phe His Asn Ala Gln Arg Val Ile Phe Lys His Leu 
1               5                   10                  15      


Tyr Lys Ala Phe Asp Ala Ser Leu Arg Met Val Lys Glu Asp Tyr Lys 
            20                  25                  30          


Ala His Phe Thr Val Asn Leu Thr Arg Asp Phe Ala His Leu Asn Arg 
        35                  40                  45              


Lys Gly Lys Asn Lys Gln Asp Asn Pro Asp Phe Asn Arg Tyr Arg Phe 
    50                  55                  60                  


Glu Lys Asp Gly Phe Phe Thr Glu Ser Gly Leu Leu Phe Phe Thr Asn 
65                  70                  75                  80  


Leu Phe Leu Asp Lys Arg Asp Ala Tyr Trp Met Leu Lys Lys Val Ser 
                85                  90                  95      


Gly Phe Lys Ala Ser His Lys Gln Ser Glu Lys Met Thr Thr Glu Val 
            100                 105                 110         


Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu Glu Ser Arg 
        115                 120                 125             


Tyr Asp His Asn Gln Met Leu Leu Asp Met Leu Ser Glu Leu Ser Arg 
    130                 135                 140                 


Cys Pro Lys Leu Leu Tyr Glu Lys Leu Ser Glu Lys Asp Lys Lys Cys 
145                 150                 155                 160 


Phe Gln Val Glu Ala Asp Gly Phe Leu Asp Glu Ile Glu Glu Glu Gln 
                165                 170                 175     


Asn Pro Phe Lys Asp Thr Leu Ile Arg His Gln Asp Arg Phe Pro Tyr 
            180                 185                 190         


Phe Ala Leu Arg Tyr Leu Asp Leu Asn Glu Ser Phe Lys Ser Ile Arg 
        195                 200                 205             


Phe Gln Val Asp Leu Gly Thr Tyr His Tyr Cys Ile Tyr Asp Lys Lys 
    210                 215                 220                 


Ile Gly Tyr Glu Gln Glu Lys Arg His Leu Thr Arg Thr Leu Leu Asn 
225                 230                 235                 240 


Phe Gly Arg Leu Gln Asp Phe Thr Glu Ile Asn Arg Pro Gln Glu Trp 
                245                 250                 255     


Lys Ala Leu Thr Lys Asp Leu Asp Tyr Asn Glu Thr Ser Asn Gln Pro 
            260                 265                 270         


Phe Ile Ser Lys Thr Thr Pro His Tyr His Ile Thr Asp Asn Lys Ile 
        275                 280                 285             


Gly Phe Arg Leu Arg Thr Ser Lys Glu Leu Tyr Pro Ser Leu Glu Val 
    290                 295                 300                 


Lys Asp Gly Ala Asn Arg Ile Ala Lys Tyr Pro Tyr Asn Ser Asp Phe 
305                 310                 315                 320 


Val Ala His Ala Phe Ile Ser Ile Ser Val His Glu Leu Leu Pro Leu 
                325                 330                 335     


Met Phe Tyr Gln His Leu Thr Gly Lys Ser Glu Asp Leu Leu Lys Glu 
            340                 345                 350         


Thr Val Arg His Ile Gln Arg Ile Tyr Lys Asp Phe Glu Glu Glu Arg 
        355                 360                 365             


Ile Asn Thr Ile Glu Asp Leu Glu Lys Ala Asn Gln Gly Arg Leu Pro 
    370                 375                 380                 


Leu Gly Ala Phe Pro Lys Gln Met Leu Gly Leu Leu Gln Asn Lys Gln 
385                 390                 395                 400 


Pro Asp Leu Ser Glu Lys Ala Lys Ile Lys Ile Glu Lys Leu Ile Ala 
                405                 410                 415     


Glu Thr Lys Leu Leu Ser His Arg Leu Asn Thr Lys Leu Lys Ser Ser 
            420                 425                 430         


Pro Lys Leu Gly Lys Arg Arg Glu Lys Leu Ile Lys Thr Gly Val Leu 
        435                 440                 445             


Ala Asp Trp Leu Val Lys Asp Phe Met Arg Phe Gln Pro Val Val Tyr 
    450                 455                 460                 


Asp Ala Gln Asn Gln Pro Ile Lys Ser Ser Lys Ala Asn Ser Thr Glu 
465                 470                 475                 480 


Ser Arg Leu Ile Arg Arg Ala Leu Ala Leu Tyr Gly Gly Glu Lys Asn 
                485                 490                 495     


Arg Leu Glu Gly Tyr Phe Lys Gln Thr Asn Leu Ile Gly Asn Thr Asn 
            500                 505                 510         


Pro His Pro Phe Leu Asn Lys Phe Asn Trp Lys Ala Cys Arg Asn Leu 
        515                 520                 525             


Val Asp Phe Tyr Gln Gln Tyr Leu Glu Gln Arg Glu Lys Phe Leu Glu 
    530                 535                 540                 


Ala Ile Lys His Gln Pro Trp Glu Pro Tyr Gln Tyr Cys Leu Leu Leu 
545                 550                 555                 560 


Lys Val Pro Lys Glu Asn Arg Lys Asn Leu Val Lys Gly Trp Glu Gln 
                565                 570                 575     


Gly Gly Ile Ser Leu Pro Arg Gly Leu Phe Thr Glu Ala Ile Arg Glu 
            580                 585                 590         


Thr Leu Ser Lys Asp Leu Thr Leu Ser Lys Pro Ile Arg Lys Glu Ile 
        595                 600                 605             


Lys Lys His Gly Arg Val Gly Phe Ile Ser Arg Ala Ile Thr Leu Tyr 
    610                 615                 620                 


Phe Lys Glu Lys Tyr Gln Asp Lys His Gln Ser Phe Tyr Asn Leu Ser 
625                 630                 635                 640 


Tyr Lys Leu Glu Ala Lys Ala Pro Leu Leu Lys Lys Glu Glu His Tyr 
                645                 650                 655     


Glu Tyr Trp Gln Gln Asn Lys Pro Gln Ser Pro Thr Glu Ser Gln Arg 
            660                 665                 670         


Leu Glu Leu His Thr Ser Asp Arg Trp Lys Asp Tyr Leu Leu Tyr Lys 
        675                 680                 685             


Arg Trp Gln His Leu Glu Lys Lys Leu Arg Leu Tyr Arg Asn Gln Asp 
    690                 695                 700                 


Ile Met Leu Trp Leu Met Thr Leu Glu Leu Thr Lys Asn His Phe Lys 
705                 710                 715                 720 


Glu Leu Asn Leu Asn Tyr His Gln Leu Lys Leu Glu Asn Leu Ala Val 
                725                 730                 735     


Asn Val Gln Glu Ala Asp Ala Lys Leu Asn Pro Leu Asn Gln Thr Leu 
            740                 745                 750         


Pro Met Val Leu Pro Val Lys Val Tyr Pro Thr Thr Ala Phe Gly Glu 
        755                 760                 765             


Val Gln Tyr His Glu Thr Pro Ile Arg Thr Val Tyr Ile Arg Glu Glu 
    770                 775                 780                 


Gln Thr Lys Ala Leu Lys Met Gly Asn Phe Lys Ala Leu Val Lys Asp 
785                 790                 795                 800 


Arg His Leu Asn Gly Leu Phe Ser Phe Ile Lys Glu Glu Asn Asp Thr 
                805                 810                 815     


Gln Lys His Pro Ile Ser Gln Leu Arg Leu Arg Arg Glu Leu Glu Ile 
            820                 825                 830         


Tyr Gln Ser Leu Arg Val Asp Ala Phe Lys Glu Thr Leu Ser Leu Glu 
        835                 840                 845             


Glu Lys Leu Leu Asn Lys His Ala Ser Leu Ser Ser Leu Glu Asn Glu 
    850                 855                 860                 


Phe Arg Thr Leu Leu Glu Glu Trp Lys Lys Lys Tyr Ala Ala Ser Ser 
865                 870                 875                 880 


Met Val Thr Asp Lys His Ile Ala Phe Ile Ala Ser Val Arg Asn Ala 
                885                 890                 895     


Phe Cys His Asn Gln Tyr Pro Phe Tyr Lys Glu Thr Leu His Ala Pro 
            900                 905                 910         


Ile Leu Leu Phe Thr Val Ala Gln Pro Thr Thr Glu Glu Lys Asp Gly 
        915                 920                 925             


Leu Gly Ile Ala Glu Ala Leu Leu Arg Val Leu Arg Glu Tyr Cys Glu 
    930                 935                 940                 


Ile Val Lys Ser Gln Ile 
945                 950 


<210>  2293
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2293

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Thr 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2294
<211>  948
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2294

Leu Phe Phe Ser Phe His Asn Ala Gln Arg Val Ile Phe Lys His Leu 
1               5                   10                  15      


Tyr Lys Ala Phe Asp Ala Ser Leu Arg Met Val Lys Glu Asp Tyr Lys 
            20                  25                  30          


Ala His Phe Thr Val Asn Leu Thr Arg Asp Phe Ala His Leu Asn Arg 
        35                  40                  45              


Lys Gly Lys Asn Lys Gln Asp Asn Pro Asp Phe Asn Arg Tyr Arg Phe 
    50                  55                  60                  


Glu Lys Asp Gly Phe Phe Thr Glu Ser Gly Leu Leu Phe Phe Thr Asn 
65                  70                  75                  80  


Leu Phe Leu Asp Lys Arg Asp Ala Tyr Trp Met Leu Lys Lys Val Ser 
                85                  90                  95      


Gly Phe Lys Ala Ser His Lys Gln Arg Glu Lys Met Thr Thr Glu Val 
            100                 105                 110         


Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu Glu Ser Arg 
        115                 120                 125             


Tyr Asp His Asn Gln Met Leu Leu Asp Met Leu Ser Glu Leu Ser Arg 
    130                 135                 140                 


Cys Pro Lys Leu Leu Tyr Glu Lys Leu Ser Glu Glu Asn Lys Lys His 
145                 150                 155                 160 


Phe Gln Val Glu Ala Asp Gly Phe Leu Asp Glu Ile Glu Glu Glu Gln 
                165                 170                 175     


Asn Pro Phe Lys Asp Thr Leu Ile Arg His Gln Asp Arg Phe Pro Tyr 
            180                 185                 190         


Phe Ala Leu Arg Tyr Leu Asp Leu Asn Glu Ser Phe Lys Ser Ile Arg 
        195                 200                 205             


Phe Gln Val Asp Leu Gly Thr Tyr His Tyr Cys Ile Tyr Asp Lys Lys 
    210                 215                 220                 


Ile Gly Asp Glu Gln Glu Lys Arg His Leu Thr Arg Thr Leu Leu Ser 
225                 230                 235                 240 


Phe Gly Arg Leu Gln Asp Phe Thr Glu Ile Asn Arg Pro Gln Glu Trp 
                245                 250                 255     


Lys Ala Leu Thr Lys Asp Leu Asp Tyr Lys Glu Thr Ser Asn Gln Pro 
            260                 265                 270         


Phe Ile Ser Lys Thr Thr Pro His Tyr His Ile Thr Asp Asn Lys Ile 
        275                 280                 285             


Gly Phe Arg Leu Gly Thr Ser Lys Glu Leu Tyr Pro Ser Leu Glu Ile 
    290                 295                 300                 


Lys Asp Gly Ala Asn Arg Ile Ala Lys Tyr Pro Tyr Asn Ser Gly Phe 
305                 310                 315                 320 


Val Ala His Ala Phe Ile Ser Val His Glu Leu Leu Pro Leu Met Phe 
                325                 330                 335     


Tyr Gln His Leu Thr Gly Lys Ser Glu Asp Leu Leu Lys Glu Thr Val 
            340                 345                 350         


Arg His Ile Gln Arg Ile Tyr Lys Asp Phe Glu Glu Glu Arg Ile Asn 
        355                 360                 365             


Thr Ile Glu Asp Leu Glu Lys Ala Asn Gln Gly Arg Leu Pro Leu Gly 
    370                 375                 380                 


Ala Phe Pro Lys Gln Met Leu Gly Leu Leu Gln Asn Lys Gln Pro Asp 
385                 390                 395                 400 


Leu Ser Glu Lys Ala Lys Ile Lys Ile Glu Lys Leu Ile Ala Glu Thr 
                405                 410                 415     


Lys Leu Leu Ser His Arg Leu Asn Thr Lys Leu Lys Ser Ser Pro Lys 
            420                 425                 430         


Leu Gly Lys Arg Arg Glu Lys Leu Ile Lys Thr Gly Val Leu Ala Asp 
        435                 440                 445             


Trp Leu Val Lys Asp Phe Met Arg Phe Gln Pro Val Ala Tyr Asp Ala 
    450                 455                 460                 


Gln Asn Gln Pro Ile Lys Ser Ser Lys Ala Asn Ser Thr Glu Phe Trp 
465                 470                 475                 480 


Phe Ile Arg Arg Ala Leu Ala Leu Tyr Gly Gly Glu Lys Asn Arg Leu 
                485                 490                 495     


Glu Gly Tyr Phe Lys Gln Thr Asn Leu Ile Gly Asn Thr Asn Pro His 
            500                 505                 510         


Pro Phe Leu Asn Lys Phe Asn Trp Lys Ala Cys Arg Asn Leu Val Asp 
        515                 520                 525             


Phe Tyr Gln Gln Tyr Leu Glu Gln Arg Glu Lys Phe Leu Glu Ala Ile 
    530                 535                 540                 


Lys Asn Gln Pro Trp Glu Pro Tyr Gln Tyr Cys Leu Leu Leu Lys Ile 
545                 550                 555                 560 


Pro Lys Glu Asn Arg Lys Asn Leu Val Lys Gly Trp Glu Gln Gly Gly 
                565                 570                 575     


Ile Ser Leu Pro Arg Gly Leu Phe Thr Glu Ala Ile Arg Glu Thr Leu 
            580                 585                 590         


Ser Glu Asp Leu Met Leu Ser Lys Pro Ile Arg Lys Glu Ile Lys Lys 
        595                 600                 605             


His Gly Arg Val Gly Phe Ile Ser Arg Ala Ile Thr Leu Tyr Phe Lys 
    610                 615                 620                 


Glu Lys Tyr Gln Asp Lys His Gln Ser Phe Tyr Asn Leu Ser Tyr Lys 
625                 630                 635                 640 


Leu Glu Ala Lys Ala Pro Leu Leu Lys Arg Glu Glu His Tyr Glu Tyr 
                645                 650                 655     


Trp Gln Gln Asn Lys Pro Gln Ser Pro Thr Glu Ser Gln Arg Leu Glu 
            660                 665                 670         


Leu His Thr Ser Asp Arg Trp Lys Asp Tyr Leu Leu Tyr Lys Arg Trp 
        675                 680                 685             


Gln His Leu Glu Lys Lys Leu Arg Leu Tyr Arg Asn Gln Asp Val Met 
    690                 695                 700                 


Leu Trp Leu Met Thr Leu Glu Leu Thr Lys Asn His Phe Lys Glu Leu 
705                 710                 715                 720 


Asn Leu Asn Tyr His Gln Leu Lys Leu Glu Asn Leu Ala Val Asn Val 
                725                 730                 735     


Gln Glu Ala Asp Ala Lys Leu Asn Pro Leu Asn Gln Thr Leu Pro Met 
            740                 745                 750         


Val Leu Pro Val Lys Val Tyr Pro Ala Thr Ala Phe Gly Glu Val Gln 
        755                 760                 765             


Tyr His Lys Thr Pro Ile Arg Thr Val Tyr Ile Arg Glu Glu His Thr 
    770                 775                 780                 


Lys Ala Leu Lys Met Gly Asn Phe Lys Ala Leu Val Lys Asp Arg Arg 
785                 790                 795                 800 


Leu Asn Gly Leu Phe Ser Phe Ile Lys Glu Glu Asn Asp Thr Gln Lys 
                805                 810                 815     


His Pro Ile Ser Gln Leu Arg Leu Arg Arg Glu Leu Glu Ile Tyr Gln 
            820                 825                 830         


Ser Leu Arg Val Asp Ala Phe Lys Glu Thr Leu Ser Leu Glu Glu Lys 
        835                 840                 845             


Leu Leu Asn Lys His Thr Ser Leu Ser Ser Leu Glu Asn Glu Phe Arg 
    850                 855                 860                 


Ala Leu Leu Glu Glu Trp Lys Lys Glu Tyr Ala Ala Ser Ser Met Val 
865                 870                 875                 880 


Thr Asp Glu His Ile Ala Phe Ile Ala Ser Val Arg Asn Ala Phe Cys 
                885                 890                 895     


His Asn Gln Tyr Pro Phe Tyr Lys Glu Ala Leu His Ala Pro Ile Pro 
            900                 905                 910         


Leu Phe Thr Val Ala Gln Pro Thr Thr Glu Glu Lys Asp Gly Leu Gly 
        915                 920                 925             


Ile Ala Glu Ala Leu Leu Lys Val Leu Arg Glu Tyr Cys Glu Ile Val 
    930                 935                 940                 


Lys Ser Gln Ile 
945             


<210>  2295
<211>  1138
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2295

Met Pro Val Ser Asn His Gln Gln Lys Gly His Lys Thr Tyr Phe Thr 
1               5                   10                  15      


Asn His Ser Asn Lys Ala Glu Ile Ser Val Phe Val Asn Thr Ala Leu 
            20                  25                  30          


Asn Asn Ile Tyr Arg Ile Ile Lys Thr Ile Glu Glu Asn Val Phe Gln 
        35                  40                  45              


Ala Val Pro Asp Tyr Asn Arg Glu Glu Met Tyr Lys Ser Gln Val Phe 
    50                  55                  60                  


Thr Val Leu Phe Ser Lys Arg Asn Glu Val Lys Lys Glu Arg Ile Ile 
65                  70                  75                  80  


Gln Tyr Leu Thr Arg Trp Leu Pro Trp Phe Ser Lys Gly Leu Thr Ile 
                85                  90                  95      


Thr Asp Pro Arg Arg Phe Ala Leu Arg Leu Val Val Tyr Ile Gln Lys 
            100                 105                 110         


Leu Val Glu Leu Arg Asn Phe Tyr Ser His Ser Leu Lys Asn Val Val 
        115                 120                 125             


Asn Leu Asn Leu Tyr Thr Asn Ala His Val Pro Ser Ser Ala Lys Asp 
    130                 135                 140                 


Val Phe Ile Asp Leu Val Cys Asp Ile Arg Arg Glu Glu Arg Asp Lys 
145                 150                 155                 160 


Lys Asp Ser Phe Ile Pro Phe Asp His Val Lys Ala Glu Tyr Lys Asp 
                165                 170                 175     


Tyr Met Phe Asp Ala Ile Leu His Glu Asp Leu Asn Arg Glu Lys Tyr 
            180                 185                 190         


Ala Cys Tyr Glu Gln Asp Tyr Cys Asn Phe Arg Ala Asp Phe Lys Gln 
        195                 200                 205             


Leu Tyr Lys Ser Thr Lys Asn Glu Val Arg Glu Arg Phe Lys Lys Glu 
    210                 215                 220                 


Arg Asn Leu Asn Asp Glu Lys Leu Lys Lys Gln Gly Val Ile Phe Ser 
225                 230                 235                 240 


Ala Gly Lys Gly Pro Asp Ser Lys Gln Asn Ala Asn Lys Leu Thr Glu 
                245                 250                 255     


Phe Gly Leu Val Phe Phe Ile Ser Ile Phe Leu Glu Arg Arg Met Val 
            260                 265                 270         


Ala Asp Phe Leu Asp Thr Val Tyr Pro Asn Asp Ile Gly Phe Met Asp 
        275                 280                 285             


Lys Leu Val Lys Arg Ser Leu Thr Ile Tyr Asn Ala Lys Pro Pro Lys 
    290                 295                 300                 


Glu Gln Leu Ile Ser Met Asp Arg Lys Phe Ala Leu Gly Leu Asp Ile 
305                 310                 315                 320 


Leu Asn Met Leu Asn Arg Val Pro Asn Tyr Ile Tyr Asp His Leu Thr 
                325                 330                 335     


Asp Gly Ala Lys Glu Lys Ala Ile Asp Glu Glu Gly Ile Val Met Lys 
            340                 345                 350         


Arg Tyr Asn Asp Arg Phe Pro Tyr Leu Ile Leu Gln Cys Leu Glu Tyr 
        355                 360                 365             


Ser Gly Lys Leu Glu Gly Leu Gln Leu Met Cys Leu Ile Gly Lys Asn 
    370                 375                 380                 


Phe Asn Ala Lys Pro Tyr His Lys Gln Phe Glu Gly Lys Ser Glu Ile 
385                 390                 395                 400 


Arg Glu Ile His Lys Thr Leu Tyr Ala Phe Asp His Leu Ser Asp Ile 
                405                 410                 415     


Arg Glu Asn Asp Lys Tyr Tyr Gln Glu Leu Arg Ser Lys Asp His Glu 
            420                 425                 430         


Val Asn Tyr Asn Ile Gly Glu Glu Glu Leu Ala Ile Ile Asn Glu Ile 
        435                 440                 445             


Lys Asn Leu His Thr Tyr Pro Leu Tyr Gln Tyr Tyr Pro Lys Tyr Gly 
    450                 455                 460                 


Ile His Glu Tyr Ser Thr Trp Lys Tyr Ile Gly Phe Val Phe Gln Asp 
465                 470                 475                 480 


Glu Ser Ile Gly Pro Pro Val Ile Ala Gln Ser Glu Glu Ser Glu Thr 
                485                 490                 495     


Arg Ile Val Ile Thr Pro Glu Phe Arg Val Asn Asn Thr Gln His Gln 
            500                 505                 510         


Phe Thr Leu Asp Gln Ser Leu Leu Lys Tyr Leu Ala Tyr Leu Leu Lys 
        515                 520                 525             


Gly Glu Ser Thr Val Ser Glu Asn Glu Asn Gly Leu Ala Ser Phe Lys 
    530                 535                 540                 


Asp Leu Cys Leu Gln Phe Lys Ser Asp Phe Val Arg Leu Leu Asn Asp 
545                 550                 555                 560 


Ile Arg Asp Gln Asn Ile Thr Pro Asp Ser Asp Tyr Asp Tyr Ser Gln 
                565                 570                 575     


Ile Leu Asn Ser Tyr Asn Ile Pro Ser Ala Cys Ile Pro Lys Arg Ile 
            580                 585                 590         


Lys Lys Tyr Leu Asn Ala Lys Gln Ser Ser Asn Asn Ser Arg Lys Leu 
        595                 600                 605             


Ile Lys Thr Lys Leu Glu Tyr Met Leu Cys Glu Thr Lys Cys Leu Leu 
    610                 615                 620                 


Ala Glu Asn Pro Val Arg Ser Lys Pro Leu Pro Lys Glu Glu Tyr Ile 
625                 630                 635                 640 


Asn Arg Lys Lys Glu Ser Gln Tyr Phe Leu Met Arg Gly Asp Lys Ala 
                645                 650                 655     


Thr Trp Ile Thr Asn Asp Ile Leu Phe Phe Met Lys Pro Lys Leu Val 
            660                 665                 670         


Ser Ile Glu Lys Glu Gly Gln Lys Thr Asn His Phe His Lys Leu Asn 
        675                 680                 685             


Asn Gln Gln Ala Lys Ile Leu Gln Ser Lys Leu Ala Leu Met Asp His 
    690                 695                 700                 


Asn Phe His Asp Ile Arg Ser Phe Met Lys Glu Thr Gly Val Phe Glu 
705                 710                 715                 720 


Thr Gly Ser Glu His Ile Phe Leu Thr Glu Gln Asn Ile Lys Ala Lys 
                725                 730                 735     


Tyr Gln Lys Val Asp Asn Phe Phe Val Arg Tyr Leu Gly Leu Arg Lys 
            740                 745                 750         


Ala Tyr Leu Glu Ser Thr Ile Lys Lys Leu Lys Thr Lys Asn Gln Ile 
        755                 760                 765             


Ile Asn Gln Thr Glu Leu Glu Arg Ala Tyr Tyr Tyr Ile Lys Ser Lys 
    770                 775                 780                 


Thr Ile Arg Arg Ser Val Ala Asn Glu Asp Lys His Ile Ala Ile Thr 
785                 790                 795                 800 


Thr Tyr Ile Glu Asn Leu Lys Lys Glu Pro Thr Ile Ile His Pro Glu 
                805                 810                 815     


Leu Met Lys Lys Trp Ala Asn Asp Val Tyr Gln Lys Glu Glu Ser Glu 
            820                 825                 830         


Asn Asn Gln Val His Asn Leu Ser Tyr Ile Val Asn Asp Leu Asp Glu 
        835                 840                 845             


Ser Phe Ala Arg Tyr Lys Gln Gln Trp Phe Tyr Gln Lys Asp Ser Leu 
    850                 855                 860                 


Ile Asp Gly Phe Gly Lys Arg Pro Gln Phe Gln Lys Arg Pro Glu Glu 
865                 870                 875                 880 


Val His His Val Asp Glu Arg Glu Lys Leu Ile Lys Arg Gln Lys Arg 
                885                 890                 895     


Ala Lys Arg Asn Ser Phe Asp Gln Ala Ile Glu Leu Asn Thr Leu Gln 
            900                 905                 910         


Cys Gln Asp Lys Leu Leu Trp His Tyr Leu Lys Tyr Ile Leu Val Glu 
        915                 920                 925             


Asp Gln Asn Ile Val Asp Phe Leu His Lys Gln Thr Ser Leu Ala Ser 
    930                 935                 940                 


Tyr Thr His Ser Lys Glu Asn Asp Ile Leu Lys His Glu Ile Asp Phe 
945                 950                 955                 960 


Lys Ile Glu Ala Ala Ile Arg Glu Tyr Lys Ser Asn Lys Lys Ile Thr 
                965                 970                 975     


Gly Lys Cys Lys Ile Lys Asp Ile Gly Lys Val Lys Ala Thr Leu Lys 
            980                 985                 990         


Ile Pro Leu Leu Phe Asn Lys Pro  Lys Lys Val Trp Val  Glu Gly Leu 
        995                 1000                 1005             


Leu Ser  Tyr Tyr Lys Asn Asp  Glu Ile Asp Tyr Asp  Asp Leu Met 
    1010                 1015                 1020             


Glu Ala  Ile Asp Lys Ile Lys  Ser Glu Leu Pro Ser  Ile Met Lys 
    1025                 1030                 1035             


His Phe  Met Lys Ile Glu Asp  Asp Tyr Gln Leu His  Lys Glu Ser 
    1040                 1045                 1050             


Val Tyr  Met Lys Lys Ile Glu  Asn Met Lys Glu Ala  Pro Tyr Cys 
    1055                 1060                 1065             


Ser Phe  Ala Lys Met Ile Lys  Ser Leu Lys Ile Asp  Asn Leu Leu 
    1070                 1075                 1080             


Ser Lys  Ser Ala Gly Ala Thr  Asn Leu Asp Thr Leu  Arg Asn Ala 
    1085                 1090                 1095             


Leu Leu  His Gly Ser Leu Pro  Arg Cys Glu Lys Ala  Ala Leu Lys 
    1100                 1105                 1110             


Pro Lys  Asp Ile Ser Ile Gly  Glu Phe Val Ile Ser  His Leu Thr 
    1115                 1120                 1125             


Asn Glu  Ile Gly Gln Thr Gln  Ile Thr Tyr 
    1130                 1135             


<210>  2296
<211>  1153
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2296

Met Glu Gln Glu Tyr Asp Phe Phe Asn Lys Thr Asp Lys His Phe Phe 
1               5                   10                  15      


Ala Gly Leu Phe Asn Thr Ala Leu Asn Asn Phe Asp Leu Ser Leu Ala 
            20                  25                  30          


Glu Leu Asn Lys Arg Met Asn Tyr Lys Glu Ile Lys Gly Asn Glu Lys 
        35                  40                  45              


Glu Ile Ile Ile Ile Glu Tyr Ala Phe Asn Lys Asp Glu Arg Thr Gln 
    50                  55                  60                  


Leu Asp Phe Glu Asn Asn Phe Lys Tyr Leu Ser Glu Ser Leu Ile Phe 
65                  70                  75                  80  


Leu Asn Arg Ile Pro Ser Phe Ile Ala His Lys Asn Lys Asn Gly Ser 
                85                  90                  95      


Thr Ile Ile Leu Lys Asp Phe Leu Lys Asp Phe Leu Cys Gly Leu Tyr 
            100                 105                 110         


Gln Thr Leu Leu Asn Tyr Arg Asn Tyr Tyr Thr His Phe Glu His Asp 
        115                 120                 125             


Asp Val Ala Ile Gly His Pro Leu Ile Ala Glu Phe Leu Glu Tyr Leu 
    130                 135                 140                 


Leu Phe Asn Ser Val Ser Arg Val Lys Asp Asp Arg Val Lys Thr Lys 
145                 150                 155                 160 


Ala Val Lys Asp Lys Leu Leu Ser Lys Tyr Lys Asp Asp Tyr Thr Thr 
                165                 170                 175     


Ile Ile Glu Tyr Lys Asn Lys Trp Ile Cys Asp Lys Asn Glu Glu Leu 
            180                 185                 190         


Ile Asn Glu Gly Arg Lys Thr Phe Lys Lys Ile Asn Asn Asn Ser Glu 
        195                 200                 205             


Ala Gly Tyr Asn Tyr Val Leu Asn Ser Ile Phe Arg Arg Phe Ile Asp 
    210                 215                 220                 


Asp Ser Thr Asn Thr Pro Lys Leu Gln Leu Asp Glu Lys Cys Ser Thr 
225                 230                 235                 240 


Asp Asp Gly Leu Thr Lys Val Gly Phe Ile Gln Phe Leu Ala Leu Leu 
                245                 250                 255     


Leu Asn Lys Arg Gln Val Ser Leu Leu Phe Asp Asn Ile Thr Tyr Thr 
            260                 265                 270         


Arg Tyr Thr Asp Thr Gln Leu Gln Arg Val Ile Thr Arg Trp Ile Phe 
        275                 280                 285             


Thr Tyr Glu Ser Tyr Arg Asp Ile Asn Tyr Leu Phe Lys Ser Glu Tyr 
    290                 295                 300                 


Asp Glu His Ala Leu Leu Leu Gln Met Val Ser Glu Leu Thr Lys Cys 
305                 310                 315                 320 


Pro Lys Asn Leu Tyr Pro Tyr Leu Ser Glu Lys Asn Lys Asp Asn Phe 
                325                 330                 335     


Leu Glu Asp Ile Asn Ile Tyr Phe Lys Glu Asn Ala Lys Leu Phe Glu 
            340                 345                 350         


Asp Asp Ala Leu Val Ser His Glu Val Val Arg Lys Arg Phe Glu Asp 
        355                 360                 365             


Lys Phe Pro Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe Ala Lys Phe 
    370                 375                 380                 


Pro Ser Leu Arg Phe Gln Val Asn Met Gly Lys Phe Asn His Asp Ser 
385                 390                 395                 400 


Arg Glu Lys Glu Phe Ile Ser Thr Gly Lys Lys Thr Glu Arg Leu Ile 
                405                 410                 415     


Leu Glu Asn Leu Thr Val Phe Glu Asn Leu Ser Glu Ala Thr Lys Lys 
            420                 425                 430         


Lys Asn Leu Tyr Phe Glu Lys Ser Asp Ser Lys Glu Lys Ser Asp Lys 
        435                 440                 445             


Glu Ser Asn Tyr Lys Asp Val Ser Asp Ser Ile Glu Val Ser Asp Trp 
    450                 455                 460                 


Val Glu Tyr Pro Arg Pro Lys Tyr Gln Phe Asn Lys Asn Thr Ile Gly 
465                 470                 475                 480 


Ile Trp Leu Asp Cys Asp Gly Leu Gly Asn Tyr Asp Glu Ser Pro Lys 
                485                 490                 495     


Arg Glu Asn Lys Lys Pro Thr Lys His Asp Ile Leu Asp Lys Ile Glu 
            500                 505                 510         


Leu Lys Asp Ser Phe Lys Lys Pro Ile Ala Tyr Leu Ser Leu His Glu 
        515                 520                 525             


Leu Pro Ala Leu Leu Tyr Cys Leu Leu Ile Glu Lys Lys Asp Gly Arg 
    530                 535                 540                 


Phe Ile Glu Asn Arg Ile Lys Gly Lys Ile Arg Lys Gln Arg Ser Phe 
545                 550                 555                 560 


Leu Glu Ser Leu Lys Gly Asp Tyr Gln Tyr Ser Glu Glu Glu Leu Lys 
                565                 570                 575     


Gln Phe Pro Lys Lys Ile Arg Leu Ile Leu Thr Lys Lys Ser Asn Ile 
            580                 585                 590         


Asn Ser Glu Lys Ile Lys Arg Gln Ile Ser Asn Glu Ile Lys Val Asn 
        595                 600                 605             


Pro Leu Lys Glu Ile Arg Glu Lys Tyr Thr Pro Lys Ser Glu Thr Glu 
    610                 615                 620                 


Leu Ser Leu Ser Glu Lys Gly Lys Ile Ala Thr Trp Leu Ser Lys Asp 
625                 630                 635                 640 


Ile Lys Arg Phe Val Ala Lys Asp Val Lys Gly Pro Ser Glu Glu Asp 
                645                 650                 655     


Lys Asn Lys Ser Trp Lys Gly Tyr Gln Phe Ser Glu Phe Gln Ala Leu 
            660                 665                 670         


Leu Ser Tyr Tyr Asp Ile Asp Lys Ser Lys Leu Ser Asp Phe Val Phe 
        675                 680                 685             


Lys Asp Leu Asn Phe Asn Ile Asn Lys Asp Phe Pro Phe Gln Gly Ile 
    690                 695                 700                 


Val Phe Asn Lys Ser Ser Leu Phe Asp Phe Tyr Thr His Tyr Leu Lys 
705                 710                 715                 720 


Ser Arg Arg Glu Tyr Leu Asn His Leu Leu Glu Asn Phe Ser Asn Thr 
                725                 730                 735     


Thr Asn Glu Glu Leu Leu Leu Pro Phe Lys Ala Ser Lys Phe Lys Ile 
            740                 745                 750         


Lys Glu Leu Glu Glu Tyr Arg Lys Asn Lys Leu Glu Glu Pro Val Met 
        755                 760                 765             


Leu Val Arg Gly Val Phe Asp Asp Lys Pro Thr Ala Ser Arg Glu Lys 
    770                 775                 780                 


Asp Lys Thr Glu Phe Ala Lys Trp Phe Thr Val Ser Met Asn Ser Ser 
785                 790                 795                 800 


Ser Ala Gln Lys Phe Tyr Asp Phe Asp Lys Ile Tyr Pro Leu Thr Leu 
                805                 810                 815     


Ser Val Ile Asn Gly Arg Lys Ser Glu Glu Asn Leu Thr Ile Asn Thr 
            820                 825                 830         


Lys Ala Gly Leu Thr Lys Gln Tyr Ile Pro Phe Gln Ser Ile Arg Asn 
        835                 840                 845             


Lys Asp Ser Phe Val Leu Thr Asp Phe Glu Lys Glu Glu Ile Lys Lys 
    850                 855                 860                 


Asn Ile Lys Asn Pro Asn Glu Asn Leu Asn Lys Asn Phe Tyr Lys Tyr 
865                 870                 875                 880 


Lys Gln Lys Gln Ile Tyr Lys Asn Glu Ala Thr Ile Arg Lys Thr Met 
                885                 890                 895     


Arg Asn Asp Tyr Tyr Met Leu Gln Met Ile Lys Thr Phe Phe Ile Asp 
            900                 905                 910         


Thr Asn Glu Phe Ile Asn Ser Thr Phe Glu Asn Ile Ser Leu Lys Asp 
        915                 920                 925             


Phe Tyr Leu Thr Lys Ala Glu Lys Glu Lys Ile Gln Lys Asn Ala Ile 
    930                 935                 940                 


Ser Gln Ser Glu Lys Glu Lys Gly Asp Lys Thr Asn Val Ile Phe Asn 
945                 950                 955                 960 


Glu Ser Tyr Ile Leu Asp Lys Arg Val Glu Leu Ser Leu Leu Glu Gly 
                965                 970                 975     


Lys Ile Ile Gly Asn Val Ala Leu Lys Asp Arg Gly Lys Tyr Lys Lys 
            980                 985                 990         


Leu Ser Gln Asp Gln Lys Val Lys  Gln Leu Thr Glu Tyr  Phe Asp Lys 
        995                 1000                 1005             


Thr Trp  Ser Phe Glu Glu Ile  Ile Asn Glu Ile Ser  Asp Tyr Glu 
    1010                 1015                 1020             


His Ile  Arg Ser Lys Val Phe  Phe Asn Ser Val His  Glu Leu Glu 
    1025                 1030                 1035             


Glu Lys  Ile Tyr Leu Lys Ala  Lys Thr Glu Asn Lys  Val Glu Glu 
    1040                 1045                 1050             


Leu Lys  Asp Lys Gly His His  Asn Phe Arg Asn Tyr  Leu Lys Tyr 
    1055                 1060                 1065             


Tyr Phe  Ile Asn Asp Glu His  Gln Lys Glu Glu Phe  Asn Lys Ile 
    1070                 1075                 1080             


Lys Arg  Thr Asn Ser Ile Leu  Glu Val Lys Glu Glu  Phe Lys Gln 
    1085                 1090                 1095             


Leu Ile  Leu Leu Ile Glu Ile  Arg Asn Lys Phe Ala  His Asn Gln 
    1100                 1105                 1110             


Leu Ile  Pro Lys Thr Ser Phe  Asp Tyr Leu Thr Ser  Lys Phe Ser 
    1115                 1120                 1125             


Met Glu  Thr Asn Glu Arg Val  Ala Ser Tyr Leu Asn  Arg Ile Phe 
    1130                 1135                 1140             


Asn Thr  Ile Lys Thr Glu Ile  Leu Ile Arg 
    1145                 1150             


<210>  2297
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2297

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Lys Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile His Asn Tyr Phe Arg 
    690                 695                 700                 


Ala Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2298
<211>  1128
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2298

Met Glu Thr Gln Ile Ser Asn Ile Glu Asn Lys Tyr Arg Ile Leu Asn 
1               5                   10                  15      


Asp Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Val Phe Asn Ile Ser Asn His Ile Ala Lys Glu Phe Asn Leu Pro Leu 
        35                  40                  45              


Leu Pro Glu Glu Gly His Leu Lys Asn Ser Phe Leu Cys Gln Lys Glu 
    50                  55                  60                  


Asn Lys Lys Val Asn Trp Asn His Ile Phe Ser Lys Thr Asn Arg Phe 
65                  70                  75                  80  


Leu Ser Ile Leu Lys Val Phe Asp Val Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Lys Met Thr Asp Ser Glu Gly Lys Asp Phe Ala Leu Met Ser Asp 
            100                 105                 110         


Ser Leu Lys Ile Val Phe Gly Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Asn Gly Thr Ser Arg Lys Thr Thr Val 
    130                 135                 140                 


Ser Asp Glu Met Ser Leu Phe Leu Arg Thr Asn Phe Leu Arg Ala Ile 
145                 150                 155                 160 


Gln Tyr Thr Lys Glu Arg Phe Lys Gly Val Leu Asn Asp Glu Asp Tyr 
                165                 170                 175     


Gln Leu Val Ala Ser Lys Lys Val Leu Glu Ala Asp Asn Thr Ile Thr 
            180                 185                 190         


Val Glu Gly Leu Val Phe Leu Thr Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Thr Gly Leu Lys Gly Thr Gln Asn 
    210                 215                 220                 


Asn Ser Phe Ile Ser Thr Arg Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro His Asp Arg Phe Gln Ser Asp Asp Thr Arg Gln Ala Phe Ser 
                245                 250                 255     


Leu Asp Leu Ile Asn Glu Leu Thr Arg Cys Pro Lys Glu Leu Tyr Asn 
            260                 265                 270         


Ala Ile Thr Glu Glu Gly Lys Met Lys Phe Gln Pro Lys Leu Asp Glu 
        275                 280                 285             


Pro Gly Ile Lys Asn Leu Leu Asp Asn Ser Thr Asn Asn Lys Lys Lys 
    290                 295                 300                 


Ile Asp Ala Glu Asp Tyr Asp Glu Tyr Ile Glu Ser Leu Thr Lys Arg 
305                 310                 315                 320 


Ile Arg Tyr Asn Asn Arg Phe Ser Asp Phe Ala Leu Lys Tyr Ile Glu 
                325                 330                 335     


Glu Thr Asp Ile Leu Gly Asp Phe Arg Phe Gln Ile Asp Leu Gly Lys 
            340                 345                 350         


Leu Phe Val Asp Glu Tyr Asp Lys Phe Phe Asn Gly Glu Glu Val Pro 
        355                 360                 365             


Arg Arg Ile Ile Glu Asn Val Lys Ala Phe Gly Lys Leu Asn Asp Phe 
    370                 375                 380                 


Asn Asp Glu Ser Ile Leu Leu Ala Gln Ile Glu Asn Gly Tyr Pro Ser 
385                 390                 395                 400 


Lys Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Thr Glu Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Val Lys Val Asp Thr Ala Lys Leu Arg Ser Asn Ser 
            420                 425                 430         


Lys Gly Glu Pro Gly Lys Asn Leu Asn Gln Pro Leu Pro Glu Ala Phe 
        435                 440                 445             


Leu Ser Leu Asn Glu Leu Pro Lys Ile Ile Leu Leu Asp Tyr Leu Gln 
    450                 455                 460                 


Lys Gly Glu Pro Glu Gln Leu Ile Asn Asp Phe Ile Leu Ile Asn Asn 
465                 470                 475                 480 


Ser Lys Leu Met Lys Met Ser Phe Ile Glu Glu Ile Lys Asn Leu Leu 
                485                 490                 495     


Pro Lys Glu Trp Asn Glu Phe Arg Lys Arg Ala Asp Thr Arg Lys Gln 
            500                 505                 510         


Ala Ala Tyr Asn Asn Glu Thr Leu Ala Tyr Leu Leu Glu Arg Lys Gln 
        515                 520                 525             


Ile Leu Asn Gln Val Leu Val Ser Tyr Gln Leu Asn Asp Lys Gln Ile 
    530                 535                 540                 


Pro Gly Arg Ile Leu Asp Tyr Trp Leu Asn Ile Lys Glu Val Glu Glu 
545                 550                 555                 560 


Gly Arg Ala Val Ser Asp Arg Leu Lys Leu Met Lys Arg Asp Cys Met 
                565                 570                 575     


Ser Arg Leu Lys Ala Leu Glu Lys Phe Lys Ile Asp Arg Asn Arg Ser 
            580                 585                 590         


Lys Ile Pro Lys Thr Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile 
        595                 600                 605             


Val Asp Met Val Val Ser Glu Gly Ile Lys Lys Lys Ile Thr Ser Phe 
    610                 615                 620                 


Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Pro Glu 
625                 630                 635                 640 


Lys Lys Arg Leu Phe Ile His Ile Val Ile Arg Glu Leu Arg Leu Asn 
                645                 650                 655     


Gly Thr Gly Gly His Pro Phe Leu Phe Gln Leu Asn Phe Asp Lys Ile 
            660                 665                 670         


Asn Cys Thr Ser Asp Phe Tyr Ser Glu Tyr Leu Arg Glu Lys Gly His 
        675                 680                 685             


Lys Met Val Lys Glu Lys Asn Leu Lys Thr Gly Lys Ile Val Leu Thr 
    690                 695                 700                 


Asp His Ser Trp Met Ala Leu Thr Phe Tyr Lys Leu Glu Phe Asn Asp 
705                 710                 715                 720 


Lys Val Asp Lys Leu Met Thr Val Val Lys Leu Pro Leu Asn Lys Leu 
                725                 730                 735     


Asn Ile Pro Phe Thr Leu Arg Gln Leu Glu Gly Lys Thr Ile Asn Thr 
            740                 745                 750         


Leu Glu Gln Trp Leu Gln Asn Ile Thr Lys Gly Lys Asn Gln Asn Asp 
        755                 760                 765             


Gly Lys His Pro Val Asn Leu Pro Thr Asn Leu Phe Asp Glu Arg Leu 
    770                 775                 780                 


Thr Ala Cys Leu Gln Lys Glu Leu Asp Lys Lys Gln Ile Ile Tyr Pro 
785                 790                 795                 800 


Pro Tyr Ala Asn Trp Asn Glu Leu Phe Lys Thr Trp Trp Lys Ser Arg 
                805                 810                 815     


Asn Asp Ser Thr Gln Ser Phe Tyr Asn Ala Glu Arg Glu Tyr Ile Ile 
            820                 825                 830         


Phe Asp Glu Lys Val Asn Phe Tyr Pro Asn Arg Gln Glu Lys Phe Ala 
        835                 840                 845             


Asp Tyr Tyr His His Ala Val Lys Ala Ala Tyr Gln Lys Lys Arg Asn 
    850                 855                 860                 


Glu Arg Thr Leu Gln Gln Lys Asp Asp Lys His Leu Pro Asp Ile Leu 
865                 870                 875                 880 


Phe Ala Gln Val Glu Lys Thr Phe Lys Gln Thr Ile Ala Gly Thr Glu 
                885                 890                 895     


Lys Glu Ile Arg Met Val Gln Glu Glu Asp Arg Ile Met Leu Val Met 
            900                 905                 910         


Leu Glu Ser Leu Leu Glu Asp Gly Lys Lys Leu Gln Leu Lys Leu Ser 
        915                 920                 925             


Glu Ile Asn Thr Leu Leu Asn Ala Thr Thr Glu Ile Lys Gln Val Val 
    930                 935                 940                 


Thr Ala Lys Leu Ser Phe Asn Asp Ser Gly Glu Ile Ile Lys Asp Lys 
945                 950                 955                 960 


Thr Asn Pro Glu Ile Thr Lys Thr Ile Thr Ala Val Arg Lys Arg Lys 
                965                 970                 975     


Asp Tyr Ser Val Leu Arg Lys Phe Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Gly Tyr Phe Asp Gly Asp  Glu Ile Gln Phe Glu  Ser Leu Lys 
        995                 1000                 1005             


Ala Glu  Leu Asp Ala Tyr Asn  Lys Ala Lys Gln Glu  Val Leu Asp 
    1010                 1015                 1020             


Val Val  Phe Lys Leu Glu Lys  Lys Ile Ile Ala Lys  Asp Cys Asn 
    1025                 1030                 1035             


Gly Val  Gln Gln Leu Phe Ser  Asp Glu Thr Gly Asn  Leu Leu Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Thr Trp Leu  Lys Ser Lys 
    1055                 1060                 1065             


Gly Leu  Ile Gly Asp Ser Thr  Phe Thr Phe Leu Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Cys  Phe Ser His Asn Gln  Tyr Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Arg Phe  Ile Asp His Trp Glu  Thr Asn Arg Phe Ala  Leu Thr Ile 
    1100                 1105                 1110             


Ala Thr  Lys Tyr Asn His Glu  Ile Thr Arg Ile Met  Glu Lys Ile 
    1115                 1120                 1125             


<210>  2299
<211>  1104
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2299

Met Glu Thr Asn Glu Asn Gln Lys Asn Asn Ser Lys Thr Leu Asp Ser 
1               5                   10                  15      


Asp Lys Tyr Tyr Phe Ala Ala Tyr Leu Asn Met Ala Arg His Asn Ala 
            20                  25                  30          


Phe Ile Thr Leu Ala His Ile Thr Arg Ile Leu Gly Lys Asn Pro Ala 
        35                  40                  45              


Gly Glu Asp Gln Leu Ala Glu Met Tyr Ala Ile Lys Ile Phe Asn Pro 
    50                  55                  60                  


Val Asn Asn Ser Leu Ser Glu Asp Ile Leu Lys Ala Lys Lys Leu Ile 
65                  70                  75                  80  


Asp Lys His Phe Pro Phe Val Lys Tyr Leu Val Asn Ile Asn Asp Ser 
                85                  90                  95      


Asp Pro Glu Val Tyr Ile Ala Glu Lys Tyr His Lys Val Leu Asn Gln 
            100                 105                 110         


Tyr Ser Thr Leu Leu Asn Asp Tyr Arg Asn Tyr Tyr Thr His Thr Ala 
        115                 120                 125             


Ser Ala Ala Lys Val Asp Leu Gln Pro Asp Phe Asn Asn Gly Leu Glu 
    130                 135                 140                 


Ser Ile Phe Asp Leu Ala Val Asn Glu Val Val Lys Arg Phe Thr Leu 
145                 150                 155                 160 


Lys Glu Glu Glu Ile Asn His Leu Arg Arg Lys Ser Pro Glu Asn Thr 
                165                 170                 175     


Glu Ile Asp Asn Ser Thr Phe Lys Tyr Arg Phe Arg Arg Lys Ser Leu 
            180                 185                 190         


Pro Pro Ala Phe Asn Glu Asn Gly Met Ala Phe Phe Ile Cys Leu Phe 
        195                 200                 205             


Leu Glu Lys Asn Tyr Ser Tyr Leu Phe Leu Lys Gln Ile Thr Gly Phe 
    210                 215                 220                 


Lys Lys Asp Gly Thr Pro Gly Phe Arg Ala Ser Leu Glu Ala Tyr Thr 
225                 230                 235                 240 


Val Tyr Arg Thr Arg Ile Pro Lys Ile Arg Ile Asp Ala Glu Gln Asn 
                245                 250                 255     


Arg Glu Met Thr Leu Ala Met Asp Met Leu Gly Glu Leu Lys Lys Cys 
            260                 265                 270         


Pro Arg Glu Leu Tyr Asp Val Leu Gln Pro Glu Tyr Asp Asn Lys Phe 
        275                 280                 285             


Arg Ala Lys Leu Asn Ser Asp Asp Gly Glu Asn Glu Glu Asp Asp Tyr 
    290                 295                 300                 


Glu Thr Glu Asn Leu Phe Leu Arg Asn Gly Ser Arg Phe Ser Tyr Leu 
305                 310                 315                 320 


Ala Leu Ser Phe Ile Asp Thr Asn Asn Leu Leu Pro Gly Tyr Ser Phe 
                325                 330                 335     


His Ile Asp Leu Gly Asn Tyr Tyr Phe Arg Phe Tyr Ser Lys Met Gly 
            340                 345                 350         


Ala Asp Gly Ile Glu Arg Lys Arg Asn Ile Lys Lys His Leu Leu Thr 
        355                 360                 365             


Tyr Gly Asn Leu Val Glu Ala His Gln Gln Lys Lys Val Gln Trp Gly 
    370                 375                 380                 


Leu Leu Glu Lys Glu Asn His Glu Ile Pro Glu Asn Asn Glu Glu Pro 
385                 390                 395                 400 


Tyr Ile Thr Asn Thr Tyr Pro His Tyr His Ile Gln Asn Asn Gln Val 
                405                 410                 415     


Gly Leu Phe Ser Trp Asn Asn Ile Lys Thr Glu Leu Pro Glu Leu Lys 
            420                 425                 430         


Gly Lys Asp Thr Lys Thr Lys Ala Pro Asp Ile Trp Leu Ser Thr Tyr 
        435                 440                 445             


Glu Leu Pro Ala Ile Ile Phe Tyr Ala Leu Leu Cys Lys Lys Gln Ala 
    450                 455                 460                 


Ala Ile Pro Pro Glu Thr Ile Ile Ala Asn His Ile Glu Lys Ile Lys 
465                 470                 475                 480 


Gln Leu Phe Ser Asp Ile His Thr Gly Ile Cys Lys Pro Lys Leu Ser 
                485                 490                 495     


Gln Met Asn Ala Asp Glu Tyr Ile Lys Gln Phe Glu Ser His Tyr Val 
            500                 505                 510         


Ser Leu Ser Asp Ile Pro Lys Pro Leu Lys Glu Tyr Leu Leu Gly Glu 
        515                 520                 525             


Thr Phe Pro Asp Lys Ala Phe Glu Asp Tyr Ala His Asp Met Ile Lys 
    530                 535                 540                 


Lys Leu Phe Asp Asp Thr Ala His Arg Leu Lys Gln Leu Asp Lys Gln 
545                 550                 555                 560 


Ile Ile Lys Asp Glu Glu Ser Lys Pro Gly Val Asn Gly Glu Asp Lys 
                565                 570                 575     


Phe Asn Ser Thr Tyr Asp Asn Met Lys Ala Gly Arg Met Ala Ala Phe 
            580                 585                 590         


Leu Ala Thr Asp Met Leu Met Met Gln Pro Ser Val Ser Val Asn Glu 
        595                 600                 605             


Leu Gly Ile Lys Asp Gly Lys Asp Lys Ala Thr Gly Phe Asn Phe Gln 
    610                 615                 620                 


Ile Leu Gln Ser Cys Leu Ala Leu Tyr Gly Ala Asn His His Lys Leu 
625                 630                 635                 640 


Tyr His Ile Phe Glu Asn Cys Lys Leu Ile Asn Ser Pro Ile Pro His 
                645                 650                 655     


Pro Phe Leu Lys Asp Ile Asn Leu Pro Thr Leu Asp Thr Leu Ser Ala 
            660                 665                 670         


Phe Tyr Lys Gln Tyr Leu Ile Glu Arg Lys Lys Tyr Leu Gly Ile Cys 
        675                 680                 685             


Thr Leu Glu Lys Asn Tyr His Ala Tyr Tyr Phe Leu Lys Pro Gly Glu 
    690                 695                 700                 


Arg Arg Trp His Glu Arg Asn Asp Glu Tyr Tyr Arg Gln Leu Ala His 
705                 710                 715                 720 


Asn Tyr Leu Asn Gly Phe Gly Lys Glu Pro Asn Lys Leu Gly Phe Asn 
                725                 730                 735     


Leu Pro Arg Ser Leu Phe Thr Pro Phe Ile Lys Ser Trp Phe Ala Arg 
            740                 745                 750         


Phe Gly Asn Thr Glu Met Lys Leu Leu Ile Lys Glu Glu Ser Gln Gln 
        755                 760                 765             


Lys His Asn Ala Ala Phe Leu Ile Thr Lys Tyr Phe Glu Leu Asn Leu 
    770                 775                 780                 


Asn Asp Lys Val Gln Pro Phe Tyr Asp Phe Pro Arg Ser Tyr Phe Phe 
785                 790                 795                 800 


Thr Asp Lys Tyr Phe Ser Leu Gln Lys Ser Asn Lys Trp Pro Glu Glu 
                805                 810                 815     


Phe Thr Thr Glu Phe Leu Ser Phe Ser Glu Leu Cys Asn Lys Ser Ala 
            820                 825                 830         


Asp Phe Glu Lys Phe Tyr Lys Asp Leu Gly His His Ser Tyr Leu Asp 
        835                 840                 845             


Asp Lys Gln Arg Gln Thr Leu His Lys Asp Tyr His Asn Tyr Leu Lys 
    850                 855                 860                 


Asn Glu Lys Leu Ile Arg Leu Ala Gln Thr Thr Asp Met Val Leu Phe 
865                 870                 875                 880 


Met Ala Val Gln His Ile Phe Glu Lys Leu Lys Val Ala Asp Thr Glu 
                885                 890                 895     


Glu Phe Lys Leu Ser Ala Ile Gln Thr Pro Asp Thr Ser Asp Ile Leu 
            900                 905                 910         


Ser Leu Gln Cys Pro Phe Ser Leu Asn Ile Ala Val Tyr His Thr Asp 
        915                 920                 925             


Glu Lys Gly Asn Val Lys Arg Lys Glu Thr Pro Leu Ala Tyr Lys Lys 
    930                 935                 940                 


Ile Thr Gln Thr Asp Leu Lys Ile Lys Asn Phe Gly Asp Phe Met Arg 
945                 950                 955                 960 


Phe Thr Ala Asp Arg Arg Leu Asn Glu Leu Leu Lys Tyr Leu Pro Gln 
                965                 970                 975     


Glu Glu Val Ser Arg Ala Asp Leu Gln Arg Glu Leu Glu Glu Tyr Asp 
            980                 985                 990         


Thr Cys Arg Leu Ala Val Ala Lys  Ile Ile His Thr Phe  Glu Asn Lys 
        995                 1000                 1005             


Met Ile  Leu Arg Phe Ser Asn  Glu Met Asn Ala Met  Leu Thr Gln 
    1010                 1015                 1020             


His Ser  Tyr Ile Glu Phe Lys  Glu Ile Ser Lys Leu  Phe Tyr Thr 
    1025                 1030                 1035             


Ala Phe  Thr Glu His Leu Ala  Asp Cys Ile Lys Leu  Glu Ser Ile 
    1040                 1045                 1050             


Arg Asn  Ala Phe Met His Asn  Gln Tyr Pro Arg Pro  Glu Asp Val 
    1055                 1060                 1065             


Gly Leu  Ala Glu Val Ser Phe  Pro Gly Ile Ala Leu  Gln Leu Cys 
    1070                 1075                 1080             


Gln Gln  Ala Glu Asn Val Val  Gln Ile Phe Thr Gln  Lys Leu Thr 
    1085                 1090                 1095             


Leu Ile  Thr Asn Thr Gln 
    1100                 


<210>  2300
<211>  950
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (836)..(946)
<223>  Xaa can be any naturally occurring amino acid

<400>  2300

Met Asn Thr Ile Val Lys Asn Glu Val Lys Gln Ala Phe Asn Asn Ile 
1               5                   10                  15      


His Phe Ser Lys Gly Ser Ile Ala Pro Leu Ala Glu Lys Ala Asn Arg 
            20                  25                  30          


Asn Tyr Lys Leu Ile Thr Lys Trp His Asn Lys Gln Glu Arg Leu His 
        35                  40                  45              


Tyr Phe Ala Val Gly His Ala Phe Lys Asn Ile Asp Lys Lys Ala Leu 
    50                  55                  60                  


Phe Gly Leu Thr Tyr Asp Glu Lys Ile Asp Glu Phe Val Pro Gln Arg 
65                  70                  75                  80  


Phe Glu Lys Leu Tyr Ser Tyr His Asn Phe Thr Phe Asp Asn Glu Leu 
                85                  90                  95      


Asp Asn Leu Leu Ser Arg Ile Arg Asp Ile Asn Ser His Ser Ile His 
            100                 105                 110         


Asp Phe Ser Val Ile Lys Thr Asp Gln Tyr Lys Ser Leu Leu Pro Phe 
        115                 120                 125             


Leu Leu Glu Ser Phe Glu Val Ala Ala Met Met Ser Tyr Val Asp Glu 
    130                 135                 140                 


Asn Arg Ile Ser Leu Glu Ser Tyr Phe Asp Asn Asn Lys Glu Ala Asp 
145                 150                 155                 160 


Phe Val Lys Phe Leu Ser Asn Lys Phe Tyr Ile Glu Asn Lys Asn Leu 
                165                 170                 175     


Lys Lys Leu Ser Lys Lys Glu Ala Ile His Ala Leu Leu Phe Ile Asn 
            180                 185                 190         


Asn Pro Asn Thr Phe Asp Trp Leu Leu Phe Asn Glu His Lys Val Phe 
        195                 200                 205             


Glu Val Glu Lys Gly Glu Tyr Phe Ser His Leu Ala Gln Leu Phe Leu 
    210                 215                 220                 


Leu Ser Met Phe Leu Tyr Lys Gly Glu Ala Glu Lys Leu Ile Ser Lys 
225                 230                 235                 240 


Ile Lys Gly Phe Lys Arg Asn Glu Asp Lys Lys Glu Asn Ser Lys Arg 
                245                 250                 255     


Asn Ile Phe Thr Phe Phe Ser Lys Lys Phe Ser Ser Gln Asp Ile Asn 
            260                 265                 270         


Ser Glu Glu Ser His Leu Ile Lys Phe Arg Asp Ile Ile Gln Tyr Leu 
        275                 280                 285             


Asn His Tyr Pro Leu Val Trp Asn His Glu Ile Glu Lys Asn Thr Lys 
    290                 295                 300                 


Ser Met Pro Val Asn Met Val Met Glu Thr Ile Ile Asp Lys Glu Ile 
305                 310                 315                 320 


Asn Arg Leu Phe Pro Asp Tyr Ser Arg Asn Glu Arg Phe Lys Ile Tyr 
                325                 330                 335     


Val Lys Tyr Lys Ile Trp Gly Lys Lys His Phe Gly Lys Asn Ile Glu 
            340                 345                 350         


Arg Leu Tyr Ile Glu Thr Pro Phe Thr Ser Glu Glu Leu Lys Asp Phe 
        355                 360                 365             


Asn Tyr Val Val Phe Thr Ser Pro Glu Leu Lys Asn Glu Tyr Ala Lys 
    370                 375                 380                 


Leu Lys Val Ala Lys Ser Glu Lys Glu Lys Arg Ser Ile Glu Lys Asp 
385                 390                 395                 400 


Ile Asn Thr Leu Lys Asn Lys Arg Asn Ile Thr Leu Glu Lys Leu Gln 
                405                 410                 415     


Lys Asn Ile Glu Glu Asn Thr Leu Ile Thr Ser Tyr Gly Arg Asn Gln 
            420                 425                 430         


Asp Arg Phe Met Pro Phe Ala Cys Arg Tyr Val Ala Glu Ser Asn Tyr 
        435                 440                 445             


Phe Gly Glu Lys Ala Lys Phe Lys Leu Tyr Met Glu Arg Thr Ser Asp 
    450                 455                 460                 


Glu Gln Lys Asn Ala Glu Ser Lys Met Pro Lys Lys Ala Leu Asp Lys 
465                 470                 475                 480 


Gln Lys Tyr His Gln Gly Arg Arg Val Asp Phe Leu Thr Phe Asn Glu 
                485                 490                 495     


Ile Leu Glu Lys Tyr Pro Asp Trp Asp Thr Pro Phe Val Ile Glu Asn 
            500                 505                 510         


Asn Ala Ile Gln Ile Glu Leu Ser Asn Gly Lys Gln Ile Ser Ile Gln 
        515                 520                 525             


Arg Ala Leu Leu Val Tyr Leu Leu Glu His Ala Leu Tyr Gly Asn Ala 
    530                 535                 540                 


Asn Tyr Pro Asn Gly Glu Ser Leu Leu Asn Ala Tyr Ile Ser Thr Leu 
545                 550                 555                 560 


Glu Lys His Lys Glu Glu Lys Leu Ala Ile Leu Lys Ser His Pro Ser 
                565                 570                 575     


Leu Asn Ile Glu Asp Lys Pro Glu Tyr Lys Pro Glu Leu Lys Lys Leu 
            580                 585                 590         


Phe Pro Arg Arg Leu Val Lys Asn Tyr Phe Pro Ala Asn Glu Gln Ser 
        595                 600                 605             


Asn Asp Tyr Asn Pro Phe Ala Lys Ile Trp Glu Asp Ala Leu Asp Ser 
    610                 615                 620                 


Glu Lys Arg Tyr Lys Gln Leu Leu Glu Glu Ala Lys Gln Arg Glu Ser 
625                 630                 635                 640 


Ser Ile Asn Asn Asn Pro Asp Asn Lys Thr Lys Ser Ser Leu Val Phe 
                645                 650                 655     


Asp Phe Glu Lys Lys Asn Lys Gly Lys Asn Phe Lys Leu Arg Phe Ile 
            660                 665                 670         


Lys Lys Ala Trp Asn Leu Met Tyr Phe Lys Ala Ile Phe Thr Glu Asn 
        675                 680                 685             


Ala Asn Thr Tyr Gly His His Lys Arg Phe His Ile Thr Lys Asp Glu 
    690                 695                 700                 


Tyr Lys Asp Tyr Cys Arg Tyr Met Tyr Ala Phe Glu Glu Val Lys Thr 
705                 710                 715                 720 


Tyr Lys Glu Arg Leu Gly Lys Leu Phe Asp Ser Lys Gly Phe Phe Lys 
                725                 730                 735     


Asn Lys Glu Phe Lys Gln Leu Phe Asp Ala Ser Leu Thr Leu Asp Ser 
            740                 745                 750         


Leu Tyr Glu Lys Thr Lys Asn Lys Phe Lys Asp Trp Met Asn Lys Gln 
        755                 760                 765             


Ser Lys Lys Thr His Ser Tyr Ala Ile Glu Ser Tyr Gln His Ile Met 
    770                 775                 780                 


Asp Pro Glu Lys His Ile Val Tyr Ile Asn Leu Ser His Phe Ile Asp 
785                 790                 795                 800 


Phe Leu Phe Lys Glu Gly Ile Leu Glu Gly Lys Lys Glu Asn Gly Ile 
                805                 810                 815     


Gln Phe Lys Ser Leu His Asn Lys Asp Phe Leu Leu Gln Ala Tyr Tyr 
            820                 825                 830         


Leu Lys Asn Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        835                 840                 845             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    850                 855                 860                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
865                 870                 875                 880 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                885                 890                 895     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            900                 905                 910         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        915                 920                 925             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    930                 935                 940                 


Xaa Xaa Phe Pro Cys Thr 
945                 950 


<210>  2301
<211>  1113
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2301

Met Glu Ser Leu Ile Gln His Glu Glu Asn Lys Ala Arg Asn Leu Ile 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg His Asn 
            20                  25                  30          


Ile Phe Ser Ile Asp Asn His Leu Ala Ser Cys Phe Glu Thr Ser Lys 
        35                  40                  45              


Leu Ser Asn Glu Lys His Ile Ser Asp Ser Phe Leu Leu Ser Ala Asp 
    50                  55                  60                  


Lys Arg Lys Asn Lys Thr Asn Lys Glu Pro Ile Asn Glu Asn Leu Leu 
65                  70                  75                  80  


Phe Glu Arg Thr Leu Arg Phe Met Pro Ile Leu Arg Val Phe Asp Thr 
                85                  90                  95      


Glu Arg Leu Pro Lys Glu Val Arg Leu Asn Thr Glu Asn Met Gly Lys 
            100                 105                 110         


Asp Phe Asp Glu Met Arg Asn Cys Leu Lys Gln Ala Phe Ser Glu Leu 
        115                 120                 125             


Asn Lys Phe Arg Asn Asp Tyr Thr His Tyr Phe Ser Thr Asn Thr Glu 
    130                 135                 140                 


Thr Asn Arg Lys Leu Gln Val Thr Ser Glu Leu Glu Glu Phe Leu Thr 
145                 150                 155                 160 


Arg Ser Phe Lys Leu Ala Ile Ala Phe Thr Lys Gln Arg Met Arg Asp 
                165                 170                 175     


Val Leu Lys Glu Glu Asp Tyr Ser Leu Val Glu Lys Lys Val Met Val 
            180                 185                 190         


Leu Pro Glu Glu Arg Phe Ile Thr Thr Glu Gly Ile Val Phe Leu Ala 
        195                 200                 205             


Cys Met Phe Leu Glu Arg Glu Tyr Ala Phe Gln Phe Ile Gly Lys Val 
    210                 215                 220                 


Val Gly Leu Lys Gly Thr His Arg Asn Glu Phe Ile Ala Thr Arg Glu 
225                 230                 235                 240 


Val Leu Met Ala Tyr Cys Val Lys Leu Pro His Asp Lys Phe Ile Ser 
                245                 250                 255     


Glu Asp Ser Arg Gln Ala Leu Ile Leu Asp Ile Ala Asn Glu Leu Asn 
            260                 265                 270         


Lys Cys Pro Leu Thr Leu Tyr Asp Val Ile Thr Glu Asp Gly Arg Lys 
        275                 280                 285             


Gln Phe Arg Pro Glu Leu Thr Asp Asp Ser Lys Arg Ser Val Ile Glu 
    290                 295                 300                 


Asn Cys Ile Asn Glu Asp Leu Glu Val Asp Tyr Asp Glu Tyr Ile Gln 
305                 310                 315                 320 


Ile Leu Thr Lys Asn Val Arg Tyr Lys Asn Arg Phe Pro Tyr Phe Ala 
                325                 330                 335     


Phe Gln Tyr Ile Glu Glu Thr Lys Leu Leu Asp Asn Phe Arg Phe Ser 
            340                 345                 350         


Ile Asp Leu Gly Gln Phe Val Leu Ala Glu Tyr Glu Lys Arg Leu Ala 
        355                 360                 365             


Gly Glu Pro Thr Ser Arg Ile Val Val Glu Asn Val Lys Thr Phe Lys 
    370                 375                 380                 


Tyr Leu Arg Asn Val Ile Asn Glu Asp Val Val Phe Glu Leu Lys Glu 
385                 390                 395                 400 


Ser Asn Leu Gln Ser Asn Arg Phe Leu Gln Phe Ser Pro His Tyr Ser 
                405                 410                 415     


Ser Asn Asn Asn Lys Ile Gly Ile Ser Ser Glu Ser Gln Pro Ser Val 
            420                 425                 430         


Val Lys Ser Lys Gly Lys Ile Glu Ser Lys Ile Asp Tyr Lys Ile Lys 
        435                 440                 445             


Gln Pro Leu Pro Glu Ala Phe Val Ser Ile His Glu Leu Pro Lys Ile 
    450                 455                 460                 


Ile Leu Leu Asp Tyr Leu Ser Lys Gly Ser Val Val Lys Ile Ile Asn 
465                 470                 475                 480 


Ser Phe Ile Arg Thr Asn Lys Ser Ile Ile Leu Asp Ile Asp Lys Ile 
                485                 490                 495     


Lys Glu Ile Lys Glu Lys Leu Pro Asn Asn Glu Val Trp Val Pro Phe 
            500                 505                 510         


Arg Arg Leu Thr Asp Ser Lys Lys His Ser Ala Tyr Ser Glu Glu Gln 
        515                 520                 525             


Lys Asp Glu Ile Leu Arg Arg Lys Lys Leu Leu Asn Glu Ile Leu Ser 
    530                 535                 540                 


Ser Tyr Ser Leu Asn Ile Lys Gln Ile Pro Ser Arg Ile Ile Asp Tyr 
545                 550                 555                 560 


Trp Leu Asn Ile Ile Asp Val Arg Lys Glu Arg Ser Phe Ser Asp Arg 
                565                 570                 575     


Ile Lys Leu Met Lys Arg Asp Cys Ala Glu Arg Tyr Lys Ala Ile Lys 
            580                 585                 590         


Arg Asn Glu Lys Asp Lys Thr Val Ser Ile Pro Lys Ile Gly Glu Met 
        595                 600                 605             


Ala Thr Phe Leu Ala Lys Asp Ile Ile Ala Met Ile Ala Asp Glu Asp 
    610                 615                 620                 


Lys Lys Ser Lys Ile Thr Ser Phe Tyr Tyr Asp Lys Leu Gln Glu Cys 
625                 630                 635                 640 


Leu Ala Leu Tyr Ala Asn Ile Glu Lys Lys Lys Leu Phe Ile His Ile 
                645                 650                 655     


Val Thr Asn Glu Leu Arg Leu Asn Glu Lys Gly Gly His Pro Phe Leu 
            660                 665                 670         


Lys Gly Ile Asn Leu Asn Ser Ile Thr Arg Thr Lys Glu Leu Tyr Glu 
        675                 680                 685             


Ile Tyr Leu Ser Glu Lys Ala Tyr Lys Leu Asn Ser Arg Glu Asn Asp 
    690                 695                 700                 


Glu Ser Trp Met Ser Met Thr Phe Tyr His Gln Glu Trp Asn Glu Lys 
705                 710                 715                 720 


Ala Met Lys Lys Met Thr Lys Val Val Tyr Pro Val Asn Asp Glu Gln 
                725                 730                 735     


Ile Pro Tyr Thr Ile Lys Gln Trp Asn Lys Pro Gln Gln Leu Leu Phe 
            740                 745                 750         


Asp Arg Phe Thr Asn Glu Gln Gly Lys Ser Ser Asp Trp Val Arg Leu 
        755                 760                 765             


Lys Pro Leu Asp Leu Pro Thr Asn Leu Phe Asp Glu Glu Ile Cys Val 
    770                 775                 780                 


Gln Leu Arg Ser Arg Leu Gln Glu Ala Lys Ile Pro Phe Asp Asn Lys 
785                 790                 795                 800 


Ser Asn Tyr Ser Glu Leu Leu Lys Leu Trp Trp Glu Ser Arg Asp Asp 
                805                 810                 815     


Ser Thr Gln Pro Tyr Tyr Gln Leu Glu Arg Gln Tyr Asn Ile Tyr Asp 
            820                 825                 830         


Glu Ser Val Arg Phe Thr Leu Asn Ser Lys Asn Lys Phe Lys Asp Tyr 
        835                 840                 845             


Tyr Gln Ala Thr Leu Lys Lys Val Phe Asn Gln Lys Lys Ala Glu Arg 
    850                 855                 860                 


Glu Ala Lys Arg Arg Ile Asn Lys Arg Leu Pro Asp Ile Gln Phe Lys 
865                 870                 875                 880 


Asp Leu Glu Arg Val Phe Lys His Ala Ile Ala Glu Thr Glu Lys Gln 
                885                 890                 895     


Ile Arg Ile Ile Gln Glu Glu Asp Arg Ile Met Leu Leu Met Leu Glu 
            900                 905                 910         


Lys Leu Met Asp Asp Gln Gln Leu Lys Leu Gly Lys Ala Glu Thr Leu 
        915                 920                 925             


Leu Ser Ser Thr Val Pro Ile Lys Gln Lys Ile Gly Asp Lys Thr Asn 
    930                 935                 940                 


Ser Ser Arg Val Ile Val Ala Gln Arg Lys Gln Lys His Tyr Thr Val 
945                 950                 955                 960 


Leu Arg Lys Tyr Gln Tyr Asp Arg Arg Leu Pro Glu Leu Phe Glu Tyr 
                965                 970                 975     


Thr Thr Glu Lys Glu Glu Leu Lys Leu Glu Trp Leu Glu Asp Glu Leu 
            980                 985                 990         


Lys Ala Tyr Asn Lys Gly Lys Leu  Lys Val Phe Asp Leu  Val Phe Ser 
        995                 1000                 1005             


Leu Glu  Lys Arg Ile Ile Glu  Val Ala Lys Gln Asp  Ile Ile Ala 
    1010                 1015                 1020             


Leu Phe  Asp Lys Pro Gly Ser  Asn Asp Ser Lys Phe  Asn Val Asp 
    1025                 1030                 1035             


His Lys  Pro Tyr Ile Lys Trp  Leu Glu Lys Lys Glu  Leu Ile Asn 
    1040                 1045                 1050             


Ser Val  Glu Ala Gly Phe Met  Lys Lys Ile Arg Asn  Ser Phe Ser 
    1055                 1060                 1065             


His Asn  Gln Phe Pro Glu Cys  Gln Thr Val Glu Leu  Met Ile Ser 
    1070                 1075                 1080             


Leu Met  Ser Asp Ile Pro Ile  Ala Thr Gln Ile Val  Asn Glu Tyr 
    1085                 1090                 1095             


Glu Arg  Leu Ile Leu Arg Ile  Ser Ser Gln Ile Glu  Glu Met Lys 
    1100                 1105                 1110             


<210>  2302
<211>  1153
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2302

Met Glu Gln Glu Tyr Asp Phe Phe Asn Lys Thr Asp Lys His Phe Phe 
1               5                   10                  15      


Ala Gly Leu Phe Asn Thr Ala Leu Asn Asn Phe Asp Leu Ser Leu Ala 
            20                  25                  30          


Glu Leu Asn Lys Arg Met Asn Tyr Lys Glu Ile Lys Gly Asn Glu Lys 
        35                  40                  45              


Glu Ile Ile Ile Ile Glu Tyr Ala Phe Asn Lys Asp Glu Arg Thr Gln 
    50                  55                  60                  


Leu Asp Phe Glu Asn Asn Phe Lys Tyr Leu Ser Glu Ser Leu Ile Phe 
65                  70                  75                  80  


Leu Asn Arg Ile Pro Ser Phe Ile Ala His Lys Asn Lys Asn Gly Ser 
                85                  90                  95      


Thr Ile Ile Leu Lys Asp Phe Leu Lys Asp Phe Leu Cys Gly Leu Tyr 
            100                 105                 110         


Gln Thr Leu Leu Asn Tyr Arg Asn Tyr Tyr Thr His Phe Glu His Asp 
        115                 120                 125             


Asp Val Ala Ile Gly His Pro Leu Ile Ala Glu Phe Leu Glu Tyr Leu 
    130                 135                 140                 


Leu Phe Asn Ser Val Ser Arg Val Lys Asp Asp Arg Val Lys Thr Lys 
145                 150                 155                 160 


Ala Val Lys Asp Lys Leu Leu Ser Lys Tyr Lys Asp Asp Tyr Thr Thr 
                165                 170                 175     


Ile Ile Glu Tyr Lys Asn Lys Trp Ile Cys Asp Lys Asn Glu Glu Leu 
            180                 185                 190         


Ile Asn Glu Gly Arg Lys Thr Phe Lys Lys Ile Asn Asn Asn Ser Glu 
        195                 200                 205             


Ala Gly Tyr Asn Tyr Val Leu Asn Ser Ile Phe Arg Arg Phe Ile Asp 
    210                 215                 220                 


Asp Ser Thr Asn Thr Pro Lys Leu Gln Leu Asp Glu Lys Cys Ser Thr 
225                 230                 235                 240 


Asp Asp Gly Leu Thr Lys Val Gly Phe Ile Gln Phe Leu Ala Leu Leu 
                245                 250                 255     


Leu Asn Lys Arg Gln Val Ser Leu Leu Phe Asp Asn Ile Thr Tyr Thr 
            260                 265                 270         


Arg Tyr Thr Asp Thr Gln Leu Gln Arg Val Ile Thr Arg Trp Ile Phe 
        275                 280                 285             


Thr Tyr Glu Ser Tyr Arg Asp Ile Asn Tyr Leu Phe Lys Ser Glu Tyr 
    290                 295                 300                 


Asp Glu His Ala Leu Leu Leu Gln Met Val Ser Glu Leu Thr Lys Cys 
305                 310                 315                 320 


Pro Lys Asn Leu Tyr Pro Tyr Leu Ser Glu Lys Asn Lys Asp Asn Phe 
                325                 330                 335     


Leu Glu Asp Ile Asn Ile Tyr Phe Lys Glu Asn Ala Lys Leu Phe Glu 
            340                 345                 350         


Asp Asp Ala Leu Val Ser His Glu Val Val Arg Lys Arg Phe Glu Asp 
        355                 360                 365             


Lys Phe Pro Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe Ala Lys Phe 
    370                 375                 380                 


Pro Ser Leu Arg Phe Gln Val Asn Met Gly Lys Phe Asn His Asp Ser 
385                 390                 395                 400 


Arg Glu Lys Glu Phe Ile Ser Thr Gly Lys Lys Thr Glu Arg Leu Ile 
                405                 410                 415     


Leu Glu Asn Leu Thr Val Phe Glu Asn Leu Ser Glu Ala Thr Lys Lys 
            420                 425                 430         


Lys Asn Leu Tyr Phe Glu Lys Ser Asp Ser Lys Glu Lys Ser Asp Lys 
        435                 440                 445             


Glu Ser Asn Tyr Lys Asp Val Ser Asp Ser Ile Glu Val Ser Asp Trp 
    450                 455                 460                 


Val Glu Tyr Pro Arg Pro Lys Tyr Gln Phe Asn Lys Asn Thr Ile Gly 
465                 470                 475                 480 


Ile Trp Leu Asp Cys Asp Gly Leu Gly Asn Tyr Asp Glu Ser Pro Lys 
                485                 490                 495     


Arg Glu Asn Lys Lys Pro Thr Lys His Asp Ile Leu Asp Lys Ile Glu 
            500                 505                 510         


Leu Lys Asp Ser Phe Lys Lys Pro Ile Ala Tyr Leu Ser Leu His Glu 
        515                 520                 525             


Leu Pro Ala Leu Leu Tyr Cys Leu Leu Ile Glu Lys Lys Asp Gly Arg 
    530                 535                 540                 


Phe Ile Glu Asn Arg Ile Lys Gly Lys Ile Arg Lys Gln Arg Ser Phe 
545                 550                 555                 560 


Leu Glu Ser Leu Lys Gly Asp Tyr Gln Tyr Ser Glu Glu Glu Leu Lys 
                565                 570                 575     


Gln Phe Pro Lys Lys Ile Arg Leu Ile Leu Thr Lys Lys Ser Asn Ile 
            580                 585                 590         


Asn Ser Glu Lys Ile Lys Arg Gln Ile Ser Asn Glu Ile Lys Val Asn 
        595                 600                 605             


Pro Leu Lys Glu Ile Arg Glu Lys Tyr Thr Pro Lys Ser Glu Thr Glu 
    610                 615                 620                 


Leu Ser Leu Ser Glu Lys Gly Lys Ile Ala Thr Trp Leu Ser Lys Asp 
625                 630                 635                 640 


Ile Lys Arg Phe Val Ala Lys Asp Val Lys Gly Pro Ser Glu Glu Asp 
                645                 650                 655     


Lys Asn Lys Ser Trp Lys Gly Tyr Gln Phe Ser Glu Phe Gln Ala Leu 
            660                 665                 670         


Leu Ser Tyr Tyr Asp Ile Asp Lys Ser Lys Leu Ser Asp Phe Val Phe 
        675                 680                 685             


Lys Asp Leu Asn Phe Asn Ile Asn Lys Asp Phe Pro Phe Gln Gly Ile 
    690                 695                 700                 


Val Phe Asn Lys Ser Ser Leu Phe Asp Phe Tyr Thr His Tyr Leu Lys 
705                 710                 715                 720 


Ser Arg Arg Glu Tyr Leu Asn His Leu Leu Glu Asn Phe Ser Asn Thr 
                725                 730                 735     


Thr Asn Glu Glu Leu Leu Leu Pro Phe Lys Ala Ser Lys Phe Lys Ile 
            740                 745                 750         


Lys Glu Leu Glu Glu Tyr Arg Lys Asn Lys Leu Glu Glu Pro Val Met 
        755                 760                 765             


Leu Val Arg Gly Val Phe Asp Asp Lys Pro Thr Ala Ser Arg Glu Lys 
    770                 775                 780                 


Asp Lys Thr Glu Phe Ala Lys Trp Phe Thr Val Ser Met Asn Ser Ser 
785                 790                 795                 800 


Ser Ala Gln Lys Phe Tyr Asp Phe Asp Lys Ile Tyr Pro Leu Thr Leu 
                805                 810                 815     


Ser Val Ile Asn Gly Arg Lys Ser Glu Glu Asn Leu Thr Ile Asn Thr 
            820                 825                 830         


Lys Ala Gly Leu Thr Lys Gln Tyr Ile Pro Phe Gln Ser Ile Arg Asn 
        835                 840                 845             


Lys Asp Ser Phe Val Leu Thr Asp Phe Glu Lys Glu Glu Ile Lys Lys 
    850                 855                 860                 


Asn Ile Lys Asn Pro Asn Glu Asn Leu Asn Lys Asn Phe Tyr Lys Tyr 
865                 870                 875                 880 


Lys Gln Lys Gln Ile Tyr Lys Asn Glu Ala Thr Ile Arg Lys Thr Met 
                885                 890                 895     


Arg Asn Asp Tyr Tyr Met Leu Gln Met Ile Lys Thr Phe Phe Ile Asp 
            900                 905                 910         


Thr Asn Glu Phe Ile Asn Ser Thr Phe Glu Asn Ile Ser Leu Lys Asp 
        915                 920                 925             


Phe Tyr Leu Thr Lys Ala Glu Lys Glu Lys Ile Gln Lys Asn Ala Ile 
    930                 935                 940                 


Ser Gln Ser Glu Lys Glu Lys Gly Asp Lys Thr Asn Val Ile Phe Asn 
945                 950                 955                 960 


Glu Ser Tyr Ile Leu Asp Lys Arg Val Glu Leu Ser Leu Leu Glu Gly 
                965                 970                 975     


Lys Ile Ile Gly Asn Val Ala Leu Lys Asp Arg Gly Lys Tyr Lys Lys 
            980                 985                 990         


Leu Ser Gln Asp Gln Lys Val Lys  Gln Leu Thr Glu Tyr  Phe Asp Lys 
        995                 1000                 1005             


Thr Trp  Ser Phe Glu Glu Ile  Ile Asn Glu Ile Ser  Asp Tyr Glu 
    1010                 1015                 1020             


His Ile  Arg Ser Lys Val Phe  Phe Asn Ser Val His  Glu Leu Glu 
    1025                 1030                 1035             


Glu Lys  Ile Tyr Leu Lys Ala  Lys Thr Glu Asn Lys  Val Glu Glu 
    1040                 1045                 1050             


Leu Lys  Asp Lys Gly His His  Asn Phe Arg Asn Tyr  Leu Lys Tyr 
    1055                 1060                 1065             


Tyr Phe  Ile Asn Asp Glu His  Gln Lys Glu Glu Phe  Asn Lys Ile 
    1070                 1075                 1080             


Lys Arg  Thr Asn Ser Ile Leu  Glu Val Lys Glu Glu  Phe Lys Gln 
    1085                 1090                 1095             


Leu Ile  Leu Leu Ile Glu Ile  Arg Asn Lys Phe Ala  His Asn Gln 
    1100                 1105                 1110             


Leu Ile  Pro Lys Thr Ser Phe  Asp Tyr Leu Thr Ser  Lys Phe Ser 
    1115                 1120                 1125             


Met Glu  Thr Asn Glu Arg Val  Ala Ser Tyr Leu Asn  Arg Ile Phe 
    1130                 1135                 1140             


Asn Thr  Ile Lys Thr Glu Ile  Leu Ile Arg 
    1145                 1150             


<210>  2303
<211>  1171
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2303

Met Ala Leu Lys Gln Trp Arg Gln Ser Lys Thr Pro Asn Leu Lys Pro 
1               5                   10                  15      


Val Phe Ser Ala Tyr Leu Asn Met Ala Arg His Asn Cys Tyr Lys Ser 
            20                  25                  30          


Leu Leu His Val Ser Lys Leu Met Gln Ile Ser Glu Ser Asn Glu Glu 
        35                  40                  45              


Glu Asn Ile Thr Met Phe Ser Leu Trp Asp Lys Leu Val Lys Gly Thr 
    50                  55                  60                  


Pro Thr Glu Lys Leu Lys Ile Ile Gln Leu Leu Gln Lys His Phe Pro 
65                  70                  75                  80  


Met Met Gln Gly Ile Phe Asp Ile Glu Lys Arg Thr Asn Ile Ser Ile 
                85                  90                  95      


Ala Thr Asn Pro Lys Glu Ile Lys Arg Thr Leu His Ala Phe Phe His 
            100                 105                 110         


Val Leu Asn Ser Leu Arg Asn Glu Tyr Thr His Phe Ser Pro Asp Pro 
        115                 120                 125             


Arg Asn Thr Thr Asn Asp Ala Val Ile Ile Pro Tyr Leu Tyr Arg Cys 
    130                 135                 140                 


Met Asp Gly Ala Ala Arg Glu Ile Lys Lys Arg Phe Ser Leu Thr Ile 
145                 150                 155                 160 


Lys Lys Ala Ile Ser Leu Asn Asn Glu Glu Ser Ser Gln Ile His Asp 
                165                 170                 175     


Val Asn Lys Ala Val Glu Tyr Ile Phe Gln Cys Asp Phe Arg Lys Ala 
            180                 185                 190         


Lys Val Asn Asp Leu Asp Lys Asn Gly Lys Val Leu Tyr Gln Lys Asn 
        195                 200                 205             


Gly Lys Ile Lys Thr Lys Met Val Asp Lys Glu Asp Tyr Phe Tyr Ser 
    210                 215                 220                 


Leu Lys Glu Ser Ser Glu Thr Val Gln Asp Asp Ala Ser Lys Lys Gly 
225                 230                 235                 240 


Asn Leu Arg Lys Lys Ile Val Leu Ser Asp Ile Gly Ile Ile Phe Phe 
                245                 250                 255     


Thr Cys Leu Phe Leu Glu Lys Arg Tyr Ile Lys Asn Phe Leu Asp Ala 
            260                 265                 270         


Ile Lys Pro Trp Pro Asn Val Phe Asn Glu Ile Gln Lys Lys Ala Val 
        275                 280                 285             


Phe Glu Val Phe Ser Val Phe His Ile His Leu His Arg Glu Lys Tyr 
    290                 295                 300                 


Asp Ser Cys Arg Pro Glu Tyr Ala Leu Gly Leu Asp Met Leu Asn Glu 
305                 310                 315                 320 


Leu Gln Lys Cys Pro Ala Glu Leu Phe Asp Ile Leu Ser Asp Lys Asp 
                325                 330                 335     


Arg Asp Arg Leu Ser Val Asp Ile His Ala Gln Gly Asp Asn Ile Val 
            340                 345                 350         


Gln Asn Asp Gly Val Thr Val Lys Ser Gly Lys Val Leu Met Lys Arg 
        355                 360                 365             


Met Arg Asp Arg Phe Ala Pro Phe Ala Leu Gln Tyr Ile Asp Arg Gln 
    370                 375                 380                 


Asn Ile Phe Lys Asp Ile Arg Phe Met Val His Leu Gly Asn Tyr Arg 
385                 390                 395                 400 


Phe Lys Phe Tyr Lys Lys Arg Cys Leu Ala Asp Asp Gly Glu Asp Thr 
                405                 410                 415     


Leu Arg Thr Leu Gln Lys Glu Ile Asn Gly Phe Gly Arg Ile Gln Glu 
            420                 425                 430         


Ile Glu Met Glu Arg Lys Lys Asn Tyr Ser Ser Phe Phe Lys Glu Ala 
        435                 440                 445             


Thr Thr Lys Val Asn Glu Tyr Asn Lys Asn Val Gln Glu Leu Lys Ala 
    450                 455                 460                 


Asp Thr Thr Asp Ser Ala Pro Tyr Met Thr Asn Ser Thr Ala His Tyr 
465                 470                 475                 480 


Leu Phe Asp Gly Asn Arg Val Gly Leu Arg Leu Phe Asn Ser Glu Ser 
                485                 490                 495     


Asp Met Lys Ser Phe Val Pro Asn Val Lys Ile Gln Gly Arg Pro Ala 
            500                 505                 510         


Thr Lys Ala Ser Glu Ile Lys Leu Leu Ser Pro Asp Ala Trp Ile Ser 
        515                 520                 525             


Thr Tyr Glu Leu Pro Gly Met Ile Phe Tyr Leu Arg Leu Tyr Lys Glu 
    530                 535                 540                 


Tyr Met Gly Lys Thr Asn Gly Tyr Pro Ser Ala Glu Asp Ile Leu Lys 
545                 550                 555                 560 


Ser Tyr Ile Asp Ala Tyr His Arg Ile Phe Asp Asp Ile Lys Asn Gly 
                565                 570                 575     


Thr Phe Lys Gly Trp Asp Asp Ile Leu Tyr Gln Pro Leu Thr Lys Lys 
            580                 585                 590         


Asp Leu Pro Ile Lys Ile Lys Arg Tyr Ile Asp Gln Pro Asn Ser Thr 
        595                 600                 605             


Gln Ser Ala Tyr Phe His Lys Lys Ser Arg Thr Arg Ile Lys Ile Met 
    610                 615                 620                 


Tyr Tyr Trp Thr Leu Arg Glu Leu Lys Cys Phe Asp Thr Lys Leu Glu 
625                 630                 635                 640 


Lys Met Lys Ser Lys Asp Asn Lys Phe Lys Lys Lys Asp Tyr Val Asp 
                645                 650                 655     


Leu Arg Pro Gly Asp Ile Ala Lys Trp Leu Thr Arg Asp Ile Leu Tyr 
            660                 665                 670         


Phe Met Glu Asp Phe Asp Glu Lys Gly Thr Ile Thr Ser Ala Asn Phe 
        675                 680                 685             


Asn Ser Leu Arg Ser Ala Leu Thr Leu Ser Asp Thr Ser Lys Glu Lys 
    690                 695                 700                 


Val Tyr Gly Met Ile Ser Ser Phe Lys His Pro Phe Leu Ala Lys Ala 
705                 710                 715                 720 


Leu Glu Thr Tyr Asp Lys Glu His Asn Glu Glu Cys Phe Arg Ile Phe 
                725                 730                 735     


Asp Phe Tyr Arg Ala Tyr Leu Thr Lys Arg Ala Asp Tyr Leu Lys Gln 
            740                 745                 750         


Ile Gln Lys Ile Lys Gly Asn Glu Leu Leu Lys Leu Ala Phe Leu His 
        755                 760                 765             


Ser Thr Arg Lys Arg Trp Lys Asp Arg Gly Ile Thr Ala Ile Lys Asp 
    770                 775                 780                 


Leu Ala Met Thr Tyr Glu Gln Phe Glu Leu Pro Arg Gly Ile Phe Thr 
785                 790                 795                 800 


Pro Leu Ala Lys Lys Ile Leu Val Glu Lys Cys Gly Leu Ser Leu Asp 
                805                 810                 815     


Thr Glu Thr Glu Lys Lys Lys Leu Gly Met Ala Asn Leu Ile Asn Phe 
            820                 825                 830         


Tyr Phe Glu Ser Val Leu Lys Asp Lys Asn Gln Asp Phe Tyr Arg Trp 
        835                 840                 845             


Ser Arg His Tyr Lys Ile Phe Asp Leu Leu Glu Thr Asn Thr Ser Lys 
    850                 855                 860                 


Asn Ser Gln Ala His Asn Phe Leu Leu Pro Glu Gln Leu Thr Thr Lys 
865                 870                 875                 880 


Met Arg Lys Asn Lys Glu Phe Glu Ile Asn Asn Leu Ile Arg Asn Lys 
                885                 890                 895     


Ala Lys Lys Ala Ile Glu Ala Glu Ile Lys Tyr Lys Lys Asn Asn Pro 
            900                 905                 910         


Thr Tyr Ile Asp Tyr Phe Asn Glu Asn Phe Lys Ser Thr Thr Glu Val 
        915                 920                 925             


Ala Lys Asn Ile Leu His Asn Ala Tyr Lys Asn Tyr Asp Asp Asn Glu 
    930                 935                 940                 


Arg Ile Leu Arg Arg Tyr Ala Ile Gln Asp Arg Leu Met Phe Leu Met 
945                 950                 955                 960 


Ala Lys Asp Leu Leu Leu Gly Ile Glu Gly Ile Gly Lys Gly Ala Leu 
                965                 970                 975     


Arg Ser Phe Arg Leu Gly Asp Ile Met Pro Asn Lys Asp Lys Thr Ile 
            980                 985                 990         


Leu Asp Leu Leu Val Pro Phe Thr  Val Thr Leu Asn Ile  Asp Gly Ile 
        995                 1000                 1005             


Ser Val  Ser Ile Arg Gln Lys  Asp Ala Ile Lys Ile  Lys Arg Tyr 
    1010                 1015                 1020             


Gly Glu  Phe Tyr Arg Tyr Asn  Ser Asp Thr Arg Leu  Lys Ser Leu 
    1025                 1030                 1035             


Leu Pro  Tyr Leu Ile His Lys  Val Gly Asn Lys Ala  Glu Ile Asn 
    1040                 1045                 1050             


Ile Asp  Ile Asp Arg Glu Glu  Leu Glu Ala Glu Leu  Asn Gln Tyr 
    1055                 1060                 1065             


Asp His  Glu Arg Ile Glu Ile  Met Arg Lys Val Gln  Ser Leu Glu 
    1070                 1075                 1080             


Arg Ser  Ile Ile Ala Lys Val  Gly Gly Glu Lys Asn  Val Glu Lys 
    1085                 1090                 1095             


Glu Ile  Arg Glu Asn Phe Asn  Asn Leu Ile Thr Gln  Lys Gly Asn 
    1100                 1105                 1110             


Ile Pro  Tyr Glu Arg Gln Gly  Lys Ile Leu Val Asn  Ile Arg Asn 
    1115                 1120                 1125             


Ser Phe  Cys His Asn Glu Tyr  Ala Lys Asp Ile Asp  Phe Pro Glu 
    1130                 1135                 1140             


Asn Ile  Pro Leu Pro Gln Ile  Ala Asp Thr Ile Val  Ser Leu Phe 
    1145                 1150                 1155             


Glu Ala  Glu Arg Lys Asn Arg  Pro Lys Gly Glu Thr  Met 
    1160                 1165                 1170     


<210>  2304
<211>  1153
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2304

Met Glu Gln Glu Tyr Asp Phe Phe Asn Lys Thr Asp Lys His Phe Phe 
1               5                   10                  15      


Ala Gly Leu Phe Asn Thr Ala Leu Asn Asn Phe Asp Leu Ser Leu Ala 
            20                  25                  30          


Glu Leu Asn Lys Arg Met Asn Tyr Lys Glu Ile Lys Gly Asn Glu Lys 
        35                  40                  45              


Glu Ile Ile Ile Ile Glu Tyr Ala Phe Asn Lys Asp Glu Arg Thr Gln 
    50                  55                  60                  


Leu Asp Phe Glu Asn Asn Phe Lys Tyr Leu Ser Glu Ser Leu Ile Phe 
65                  70                  75                  80  


Leu Asn Arg Ile Pro Ser Phe Ile Ala His Lys Asn Lys Asn Gly Ser 
                85                  90                  95      


Thr Ile Ile Leu Lys Asp Phe Leu Lys Asp Phe Leu Cys Gly Leu Tyr 
            100                 105                 110         


Gln Thr Leu Leu Asn Tyr Arg Asn Tyr Tyr Thr His Phe Glu His Asp 
        115                 120                 125             


Asp Val Ala Ile Gly His Pro Leu Ile Ala Glu Phe Leu Glu Tyr Leu 
    130                 135                 140                 


Leu Phe Asn Ser Val Ser Arg Val Lys Asp Asp Arg Val Lys Thr Lys 
145                 150                 155                 160 


Ala Val Lys Asp Lys Leu Leu Ser Lys Tyr Lys Asp Asp Tyr Thr Thr 
                165                 170                 175     


Ile Ile Glu Tyr Lys Asn Lys Trp Ile Cys Asp Lys Asn Glu Glu Leu 
            180                 185                 190         


Ile Asn Glu Gly Arg Lys Thr Phe Lys Lys Ile Asn Asn Asn Ser Glu 
        195                 200                 205             


Ala Gly Tyr Asn Tyr Val Leu Asn Ser Ile Phe Arg Arg Phe Ile Asp 
    210                 215                 220                 


Asp Ser Thr Asn Thr Pro Lys Leu Gln Leu Asp Glu Lys Cys Ser Thr 
225                 230                 235                 240 


Asp Asp Gly Leu Thr Lys Val Gly Phe Ile Gln Phe Leu Ala Leu Leu 
                245                 250                 255     


Leu Asn Lys Arg Gln Val Ser Leu Leu Phe Asp Asn Ile Thr Tyr Thr 
            260                 265                 270         


Arg Tyr Thr Asp Thr Gln Leu Gln Arg Val Ile Thr Arg Trp Ile Phe 
        275                 280                 285             


Thr Tyr Glu Ser Tyr Arg Asp Ile Asn Tyr Leu Phe Lys Ser Glu Tyr 
    290                 295                 300                 


Asp Glu His Ala Leu Leu Leu Gln Met Val Ser Glu Leu Thr Lys Cys 
305                 310                 315                 320 


Pro Lys Asn Leu Tyr Pro Tyr Leu Ser Glu Lys Asn Lys Asp Asn Phe 
                325                 330                 335     


Leu Glu Asp Ile Asn Ile Tyr Phe Lys Glu Asn Ala Lys Leu Phe Glu 
            340                 345                 350         


Asp Asp Ala Leu Val Ser His Glu Val Val Arg Lys Arg Phe Glu Asp 
        355                 360                 365             


Lys Phe Pro Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe Ala Lys Phe 
    370                 375                 380                 


Pro Ser Leu Arg Phe Gln Val Asn Met Gly Lys Phe Asn His Asp Ser 
385                 390                 395                 400 


Arg Glu Lys Glu Phe Ile Ser Thr Gly Lys Lys Thr Glu Arg Leu Ile 
                405                 410                 415     


Leu Glu Asn Leu Thr Val Phe Glu Asn Leu Ser Glu Ala Thr Lys Lys 
            420                 425                 430         


Lys Asn Leu Tyr Phe Glu Lys Ser Asp Ser Lys Glu Lys Ser Asp Lys 
        435                 440                 445             


Glu Ser Asn Tyr Lys Asp Val Ser Asp Ser Ile Glu Val Ser Asp Trp 
    450                 455                 460                 


Val Glu Tyr Pro Arg Pro Lys Tyr Gln Phe Asn Lys Asn Thr Ile Gly 
465                 470                 475                 480 


Ile Trp Leu Asp Cys Asp Gly Leu Gly Asn Tyr Asp Glu Ser Pro Lys 
                485                 490                 495     


Arg Glu Asn Lys Lys Pro Thr Lys His Asp Ile Leu Asp Lys Ile Glu 
            500                 505                 510         


Leu Lys Asp Ser Phe Lys Lys Pro Ile Ala Tyr Leu Ser Leu His Glu 
        515                 520                 525             


Leu Pro Ala Leu Leu Tyr Cys Leu Leu Ile Glu Lys Lys Asp Gly Arg 
    530                 535                 540                 


Phe Ile Glu Asn Arg Ile Lys Gly Lys Ile Arg Lys Gln Arg Ser Phe 
545                 550                 555                 560 


Leu Glu Ser Leu Lys Gly Asp Tyr Gln Tyr Ser Glu Glu Glu Leu Lys 
                565                 570                 575     


Gln Phe Pro Lys Lys Ile Arg Leu Ile Leu Thr Lys Lys Ser Asn Ile 
            580                 585                 590         


Asn Ser Glu Lys Ile Lys Arg Gln Ile Ser Asn Glu Ile Lys Val Asn 
        595                 600                 605             


Pro Leu Lys Glu Ile Arg Glu Lys Tyr Thr Pro Lys Ser Glu Thr Glu 
    610                 615                 620                 


Leu Ser Leu Ser Glu Lys Gly Lys Ile Ala Thr Trp Leu Ser Lys Asp 
625                 630                 635                 640 


Ile Lys Arg Phe Val Ala Lys Asp Val Lys Gly Pro Ser Glu Glu Asp 
                645                 650                 655     


Lys Asn Lys Ser Trp Lys Gly Tyr Gln Phe Ser Glu Phe Gln Ala Leu 
            660                 665                 670         


Leu Ser Tyr Tyr Asp Ile Asp Lys Ser Lys Leu Ser Asp Phe Val Phe 
        675                 680                 685             


Lys Asp Leu Asn Phe Asn Ile Asn Lys Asp Phe Pro Phe Gln Gly Ile 
    690                 695                 700                 


Val Phe Asn Lys Ser Ser Leu Phe Asp Phe Tyr Thr His Tyr Leu Lys 
705                 710                 715                 720 


Ser Arg Arg Glu Tyr Leu Asn His Leu Leu Glu Asn Phe Ser Asn Thr 
                725                 730                 735     


Thr Asn Glu Glu Leu Leu Leu Pro Phe Lys Ala Ser Lys Phe Lys Ile 
            740                 745                 750         


Lys Glu Leu Glu Glu Tyr Arg Lys Asn Lys Leu Glu Glu Pro Val Met 
        755                 760                 765             


Leu Val Arg Gly Val Phe Asp Asp Lys Pro Thr Ala Ser Arg Glu Lys 
    770                 775                 780                 


Asp Lys Thr Glu Phe Ala Lys Trp Phe Thr Val Ser Met Asn Ser Ser 
785                 790                 795                 800 


Ser Ala Gln Lys Phe Tyr Asp Phe Asp Lys Ile Tyr Pro Leu Thr Leu 
                805                 810                 815     


Ser Val Ile Asn Gly Arg Lys Ser Glu Glu Asn Leu Thr Ile Asn Thr 
            820                 825                 830         


Lys Ala Gly Leu Thr Lys Gln Tyr Ile Pro Phe Gln Ser Ile Arg Asn 
        835                 840                 845             


Lys Asp Ser Phe Val Leu Thr Asp Phe Glu Lys Glu Glu Ile Lys Lys 
    850                 855                 860                 


Asn Ile Lys Asn Pro Asn Glu Asn Leu Asn Lys Asn Phe Tyr Lys Tyr 
865                 870                 875                 880 


Lys Gln Lys Gln Ile Tyr Lys Asn Glu Ala Thr Ile Arg Lys Thr Met 
                885                 890                 895     


Arg Asn Asp Tyr Tyr Met Leu Gln Met Ile Lys Thr Phe Phe Ile Asp 
            900                 905                 910         


Thr Asn Glu Phe Ile Asn Ser Thr Phe Glu Asn Ile Ser Leu Lys Asp 
        915                 920                 925             


Phe Tyr Leu Thr Lys Ala Glu Lys Glu Lys Ile Gln Lys Asn Ala Ile 
    930                 935                 940                 


Ser Gln Ser Glu Lys Glu Lys Gly Asp Lys Thr Asn Val Ile Phe Asn 
945                 950                 955                 960 


Glu Ser Tyr Ile Leu Asp Lys Arg Val Glu Leu Ser Leu Leu Glu Gly 
                965                 970                 975     


Lys Ile Ile Gly Asn Val Ala Leu Lys Asp Arg Gly Lys Tyr Lys Lys 
            980                 985                 990         


Leu Ser Gln Asp Gln Lys Val Lys  Gln Leu Thr Glu Tyr  Phe Asp Lys 
        995                 1000                 1005             


Thr Trp  Ser Phe Glu Glu Ile  Ile Asn Glu Ile Ser  Asp Tyr Glu 
    1010                 1015                 1020             


His Ile  Arg Ser Lys Val Phe  Phe Asn Ser Val His  Glu Leu Glu 
    1025                 1030                 1035             


Glu Lys  Ile Tyr Leu Lys Ala  Lys Thr Glu Asn Lys  Val Glu Glu 
    1040                 1045                 1050             


Leu Lys  Asp Lys Gly His His  Asn Phe Arg Asn Tyr  Leu Lys Tyr 
    1055                 1060                 1065             


Tyr Phe  Ile Asn Asp Glu His  Gln Lys Glu Glu Phe  Asn Lys Ile 
    1070                 1075                 1080             


Lys Arg  Thr Asn Ser Ile Leu  Glu Val Lys Glu Glu  Phe Lys Gln 
    1085                 1090                 1095             


Leu Ile  Leu Leu Ile Glu Ile  Arg Asn Lys Phe Ala  His Asn Gln 
    1100                 1105                 1110             


Leu Ile  Pro Lys Thr Ser Phe  Asp Tyr Leu Thr Ser  Lys Phe Ser 
    1115                 1120                 1125             


Met Glu  Thr Asn Glu Arg Val  Ala Ser Tyr Leu Asn  Arg Ile Phe 
    1130                 1135                 1140             


Asn Thr  Ile Lys Thr Glu Ile  Leu Ile Arg 
    1145                 1150             


<210>  2305
<211>  1142
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2305

Met Glu Asp Asp Lys Lys Thr Thr Glu Ser Ile Arg Tyr Glu Leu Lys 
1               5                   10                  15      


Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val 
            20                  25                  30          


Tyr Ile Thr Val Asn His Ile Asn Lys Val Leu Glu Leu Lys Asn Lys 
        35                  40                  45              


Lys Asp Gln Asp Ile Ile Ile Asp Asn Asp Gln Asp Ile Leu Ala Ile 
    50                  55                  60                  


Lys Thr His Trp Glu Lys Val Asn Gly Asp Leu Asn Lys Thr Glu Arg 
65                  70                  75                  80  


Leu Arg Glu Leu Met Thr Lys His Phe Pro Phe Leu Glu Thr Ala Ile 
                85                  90                  95      


Tyr Thr Lys Asn Lys Glu Asp Lys Glu Glu Val Lys Gln Glu Lys Gln 
            100                 105                 110         


Ala Lys Ala Gln Ser Phe Asp Ser Leu Lys His Cys Leu Phe Leu Phe 
        115                 120                 125             


Leu Glu Lys Leu Gln Glu Ala Arg Asn Tyr Tyr Ser His Tyr Lys Tyr 
    130                 135                 140                 


Ser Glu Ser Thr Lys Glu Pro Met Leu Glu Lys Glu Leu Leu Lys Lys 
145                 150                 155                 160 


Met Tyr Asn Ile Phe Asp Asp Asn Ile Arg Leu Val Ile Lys Asp Tyr 
                165                 170                 175     


Gln His Asn Lys Asp Ile Asn Pro Asp Glu Asp Phe Lys His Leu Asp 
            180                 185                 190         


Arg Thr Glu Glu Asp Phe Asn Tyr Tyr Phe Thr Arg Asn Lys Lys Gly 
        195                 200                 205             


Asn Ile Thr Ala Ser Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Glu 
    210                 215                 220                 


Lys Lys Asp Ala Ile Trp Met Gln Gln Lys Leu Arg Gly Phe Lys Asp 
225                 230                 235                 240 


Asn Arg Glu Ser Lys Lys Lys Met Thr His Glu Val Phe Cys Arg Ser 
                245                 250                 255     


Arg Met Arg Leu Pro Lys Leu Arg Leu Glu Ser Thr Gln Thr Gln Asp 
            260                 265                 270         


Trp Ile Leu Leu Asp Met Leu Asn Glu Leu Ile Arg Cys Pro Lys Ser 
        275                 280                 285             


Leu Tyr Glu Arg Leu Gln Gly Glu Asp Arg Glu Lys Phe Lys Val Pro 
    290                 295                 300                 


Phe Asp Pro Ala Asp Glu Asp Tyr Asp Ala Glu Gln Glu Pro Phe Lys 
305                 310                 315                 320 


Asn Thr Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Ala Leu Arg 
                325                 330                 335     


Tyr Phe Asp Tyr Asn Glu Ile Phe Thr Asn Leu Arg Phe Gln Ile Asp 
            340                 345                 350         


Leu Gly Thr Tyr His Phe Ser Ile Tyr Lys Lys Leu Ile Gly Gly Gln 
        355                 360                 365             


Lys Glu Asp Arg His Leu Thr His Lys Leu Tyr Gly Phe Glu Arg Ile 
    370                 375                 380                 


Gln Glu Phe Ala Lys Gln Asn Arg Pro Asp Glu Trp Lys Ala Ile Val 
385                 390                 395                 400 


Lys Asp Leu Asp Thr Tyr Glu Thr Ser Asn Glu Arg Tyr Ile Ser Glu 
                405                 410                 415     


Thr Thr Pro His Tyr His Leu Glu Asn Gln Lys Ile Gly Ile Arg Phe 
            420                 425                 430         


Arg Asn Asp Asn Asp Glu Ile Trp Pro Ser Leu Lys Thr Asn Gly Glu 
        435                 440                 445             


Asn Asn Glu Lys Arg Lys Tyr Lys Leu Asp Lys Gln Tyr Gln Ala Glu 
    450                 455                 460                 


Ala Phe Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu 
465                 470                 475                 480 


Leu Leu Lys Met Glu Asn Thr Asp Asn Gly Lys Glu Asn Asn Glu Val 
                485                 490                 495     


Gly Thr Lys Lys Lys Arg Asn Lys Asn Asn Glu Gln Glu Lys His Lys 
            500                 505                 510         


Ile Glu Glu Ile Ile Glu Asn Lys Ile Lys Asp Ile Tyr Ala Leu Tyr 
        515                 520                 525             


Asp Ala Phe Ala Asn Gly Glu Ile Asn Ser Lys Glu Glu Leu Lys Glu 
    530                 535                 540                 


Tyr Leu Lys Gly Lys Asp Ile Glu Ile Val His Leu Pro Lys Gln Met 
545                 550                 555                 560 


Ile Ala Ile Leu Glu Ser Lys Pro Lys Asp Met Val Glu Ala Ala Lys 
                565                 570                 575     


Arg Lys Gln Lys Glu Met Val Lys Asp Thr Lys Lys Leu Leu Ala Thr 
            580                 585                 590         


Leu Glu Lys Gln Thr Gln Glu Glu Ile Glu Asp Gly Gly Arg Asn Ile 
        595                 600                 605             


Arg Leu Leu Lys Ser Gly Glu Ile Ala Arg Trp Leu Val Asn Asp Met 
    610                 615                 620                 


Met Arg Phe Gln Pro Val Gln Lys Asp Asn Glu Gly Asn Pro Leu Asn 
625                 630                 635                 640 


Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln Met Leu Gln Arg Ser Leu 
                645                 650                 655     


Ala Leu Tyr Asn Lys Glu Glu Lys Pro Thr Arg Tyr Phe Arg Gln Val 
            660                 665                 670         


Asn Leu Ile Asn Ser Ser Asn Pro His Pro Phe Leu Lys Trp Thr Lys 
        675                 680                 685             


Trp Glu Glu Cys Asn Asn Ile Leu Ser Phe Tyr Arg Asn Tyr Leu Thr 
    690                 695                 700                 


Lys Lys Ile Glu Phe Leu Asn Lys Leu Lys Pro Glu Asp Trp Glu Lys 
705                 710                 715                 720 


Asn Gln Tyr Phe Leu Lys Leu Lys Glu Pro Lys Thr Asn Arg Glu Thr 
                725                 730                 735     


Leu Val Gln Gly Trp Lys Asn Gly Phe Asn Leu Pro Arg Gly Ile Phe 
            740                 745                 750         


Thr Glu Pro Ile Arg Glu Trp Phe Lys Arg His Gln Asn Asp Ser Lys 
        755                 760                 765             


Glu Tyr Glu Lys Val Glu Ala Leu Lys Arg Val Gly Leu Ile Ala Lys 
    770                 775                 780                 


Val Ile Pro Leu Phe Phe Lys Glu Glu Tyr Phe Lys Glu Asp Ala Gln 
785                 790                 795                 800 


Lys Glu Ile Asn Asn Cys Val Gln Pro Phe Tyr Ser Phe Pro Tyr Asn 
                805                 810                 815     


Val Gly Asn Ile His Lys Pro Asp Glu Lys Asp Phe Leu Leu Ser Glu 
            820                 825                 830         


Glu Arg Lys Lys Leu Trp Gly Asp Lys Lys Asn Lys Phe Lys Gly Tyr 
        835                 840                 845             


Lys Ala Lys Val Lys Ser Lys Lys Leu Thr Asp Lys Glu Lys Glu Glu 
    850                 855                 860                 


Tyr Arg Ser Tyr Leu Glu Phe Gln Ser Trp Asn Lys Phe Glu Arg Glu 
865                 870                 875                 880 


Leu Arg Leu Val Arg Asn Gln Asp Ile Val Thr Trp Leu Leu Cys Thr 
                885                 890                 895     


Glu Leu Ile Asp Lys Leu Lys Val Glu Gly Leu Asn Val Glu Glu Leu 
            900                 905                 910         


Lys Lys Leu Arg Leu Lys Asp Ile Asp Thr Asp Thr Ala Lys Gln Glu 
        915                 920                 925             


Lys Asn Asn Ile Leu Asn Arg Val Met Pro Met Gln Leu Pro Val Thr 
    930                 935                 940                 


Val Tyr Glu Ile Asp Asp Ser His Asn Ile Val Lys Asp Arg Pro Leu 
945                 950                 955                 960 


His Thr Val Tyr Ile Glu Glu Thr Lys Thr Lys Leu Leu Lys Gln Gly 
                965                 970                 975     


Asn Phe Lys Ala Leu Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser 
            980                 985                 990         


Phe Val Asp Thr Ser Ser Glu Ala  Glu Leu Lys Ser Lys  Pro Ile Ser 
        995                 1000                 1005             


Lys Ser  Val Val Glu Tyr Glu  Leu Gly Glu Tyr Gln  Asn Ala Arg 
    1010                 1015                 1020             


Ile Glu  Ile Ile Glu Asp Met  Leu Ala Leu Glu Glu  Thr Leu Ile 
    1025                 1030                 1035             


Lys Lys  Tyr Lys Thr Leu Pro  Thr Asn Lys Phe Lys  Lys Met Leu 
    1040                 1045                 1050             


Lys Gly  Trp Leu Glu Gly Lys  Asp Glu Ala Asp Lys  Ala Arg Phe 
    1055                 1060                 1065             


Gln Asn  Asp Val Lys Leu Leu  Thr Ala Val Arg Asn  Ala Phe Ser 
    1070                 1075                 1080             


His Asn  Gln Tyr Pro Met Arg  Asn Arg Ile Ala Phe  Ala Asn Ile 
    1085                 1090                 1095             


Asn Pro  Phe Ser Leu Ser Ser  Ala Asp Thr Ser Glu  Glu Lys Gly 
    1100                 1105                 1110             


Leu Asp  Ile Ala Asn Gln Leu  Lys Asp Lys Thr His  Lys Ile Ile 
    1115                 1120                 1125             


Lys Arg  Ile Ile Glu Ile Glu  Lys Pro Ile Glu Thr  Lys Glu 
    1130                 1135                 1140         


<210>  2306
<211>  1262
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2306

Leu Gln Asn Ala Lys Tyr Ile Arg Asn Phe Ala Lys Arg Arg Pro Asn 
1               5                   10                  15      


Asn Tyr Tyr Ser Lys Gln Ser Val Lys Gln Lys Tyr Met Ile Ile Lys 
            20                  25                  30          


Glu Ser Lys Gln Arg Lys Asp Lys Val Arg Thr Gln Thr Glu Asp Ser 
        35                  40                  45              


Gln Leu Ser His Asn Arg Arg Ser Pro Lys Ala Gln Met Pro Tyr Thr 
    50                  55                  60                  


Glu Asn Asp Lys Leu Arg Ser Val Tyr Ala Ala Tyr Leu Asn Met Ala 
65                  70                  75                  80  


Arg Met Asn Leu Tyr Asn Thr Leu Arg Phe Ile Gly His Leu Tyr Gly 
                85                  90                  95      


Met Asp Asp Asn Ile Gln Glu Gly Glu Met Asp Lys Met Lys Val Ala 
            100                 105                 110         


Asn Phe Ala Asn His Pro His Leu Glu Lys Arg Leu Ser Val Arg Lys 
        115                 120                 125             


Ala Leu Leu Lys His Leu Pro Phe Leu His Cys Met Ala Gln Ala Tyr 
    130                 135                 140                 


Val Asn Thr Glu His Lys Tyr Thr Asp Asp Asn Asp Leu Gln Lys Val 
145                 150                 155                 160 


Leu Leu Asn Ile Ile Asn Val Val Ser Asn Gln Arg Asp His Leu Thr 
                165                 170                 175     


His Ala Asn Pro Tyr Asn Asn Asp Ala Asp Trp Ala Lys Gln Lys Glu 
            180                 185                 190         


Ile Glu Lys Gln Leu Leu Glu Pro Leu Glu Lys Ala Phe Met Phe Ser 
        195                 200                 205             


Lys His Lys Val Glu Thr Ile Phe Asp Tyr Ser Lys Ser Asp Met Ser 
    210                 215                 220                 


Phe Ile Asp Arg Leu Glu Arg Met Met Asp Thr Gly Asp Thr Ile Ile 
225                 230                 235                 240 


Val Lys Glu Asn Asn Lys Glu Arg Glu Leu Arg Asp Asn Gln Asp His 
                245                 250                 255     


Ser Asp Tyr Tyr Phe Arg Leu Arg Thr Pro Glu Gly Asp Ala Leu Ser 
            260                 265                 270         


Thr Val Gly Leu Thr Phe Leu Ile Cys Lys Leu Leu His Lys Lys His 
        275                 280                 285             


Ala Thr Ile Phe Ala Gln Arg Thr Gly Leu Phe Leu Glu Gln Ser His 
    290                 295                 300                 


Leu Asp Gly Tyr Ser Pro Phe Ser Lys Arg Glu Asn Glu Ile Met Phe 
305                 310                 315                 320 


Asn Ile Phe Cys His Glu Arg Ile Arg Leu Pro Lys Gly Arg Leu Glu 
                325                 330                 335     


Ser Thr Thr Asp Pro Met Ala Leu Gly Leu Asp Met Leu Ala Glu Leu 
            340                 345                 350         


Gln Lys Cys Pro Ala Glu Leu Phe Asn Thr Phe Gly Pro Ser Asp Arg 
        355                 360                 365             


Lys Leu Phe Glu Val Arg Asn Glu Asp Phe Ser Thr Asp Ser Ser Thr 
    370                 375                 380                 


Glu Asp Ile Ile Leu Met Arg Arg Tyr Gly Asp Arg Phe Ala Arg Leu 
385                 390                 395                 400 


Ala Met Gln Tyr Ile Asp Ser Phe Asn Ala Asp Pro Asn His Arg Asn 
                405                 410                 415     


Lys Arg Asp Ser Ala Pro Leu Pro Gly Met Ala Phe Gln Val Ser Val 
            420                 425                 430         


Gly Lys Phe Arg His Thr Phe Tyr Glu Arg Ala Pro Phe His Glu Gly 
        435                 440                 445             


Val Lys Asp Arg Val Arg Val Leu Gln Lys Glu Ile Asn Gly Phe Gly 
    450                 455                 460                 


Pro Leu Thr Lys Ile Glu Asp Leu Arg Gln Thr Asp Tyr Ala Leu Phe 
465                 470                 475                 480 


Ile Arg Gln Val Asn Asp Asp Ser Ser Asp Arg Leu Tyr Asp Pro Asp 
                485                 490                 495     


Thr Ala Gln Thr Arg Pro Tyr Ile Thr Asp His His Ala Ser Tyr Ala 
            500                 505                 510         


Ile Thr Gly Asp Arg Ile Gly Leu Met Trp Asn Asp Glu Asn Val Gln 
        515                 520                 525             


Val Leu Asn Asn Asp Thr Leu Cys Tyr Leu Pro Glu Leu Pro Ile Pro 
    530                 535                 540                 


Thr Ala Thr Asp Asp Ser Lys Lys Pro Trp Asn Val Asp Leu Thr Val 
545                 550                 555                 560 


Phe Asn Arg Ser Asn Gly Gly His Pro Lys Gly Asn Ile Ala Pro Arg 
                565                 570                 575     


Ala Trp Leu Ser Ile Tyr Asp Leu Pro Ala Leu Ile Phe Leu His Phe 
            580                 585                 590         


Leu Gly Gly Lys Pro Ala Ser Val Ile Lys Asp Thr Tyr Asn Ser Leu 
        595                 600                 605             


Met Lys Leu Phe Asp Asp Ile Ala Glu Gly Arg Arg Asp Pro Tyr Phe 
    610                 615                 620                 


Lys Gly Gln Ile Pro Gln Asp Pro Asn Ser Arg Lys Lys Val Ile Leu 
625                 630                 635                 640 


Ser Leu Arg Glu Gln Leu Thr Pro His Leu Met Thr Asp Tyr Gly Leu 
                645                 650                 655     


His Thr Arg Asp Ile Pro Asp Lys Ile Val Glu Tyr Leu Ile Gly Glu 
            660                 665                 670         


Gly Leu Ala Ala Asn Glu Gln Thr Ala Ile Leu His Ala Glu Glu Arg 
        675                 680                 685             


Phe Arg Lys Trp Cys Asp Ile Lys Val Lys Ala Met Lys Lys Asp Leu 
    690                 695                 700                 


Asp Leu Arg Ile Glu His Phe Asn Lys Asp Lys Glu Gln Ile Gly Asn 
705                 710                 715                 720 


Ser Ser Asn Arg Ile Gly Ser Lys Arg Tyr Val Asp Leu Arg Pro Gly 
                725                 730                 735     


Ser Leu Ala Arg Tyr Leu Ala Lys Asp Met Ile Ala Met Val Asp Pro 
            740                 745                 750         


Lys Asp Gly Ala Lys Pro Ser Gly Leu Asp Phe Thr Leu Leu Gln Ala 
        755                 760                 765             


Ala Ile Ala Thr Tyr Gln Gly Asn Gly Cys Pro Leu Glu Lys Thr Glu 
    770                 775                 780                 


Leu Gly Ala Thr Ile Lys Lys Ala Phe Ala Trp Gln Ala His Pro Phe 
785                 790                 795                 800 


Leu Pro Lys Ile Met Asn Leu Thr Val Ser Asp Thr Ile Asp Leu Tyr 
                805                 810                 815     


Ser Arg Tyr Gln Asn Glu Lys Thr Lys Tyr Leu Asp Arg Leu Leu Gln 
            820                 825                 830         


Ser His Lys Tyr Ser Asp Thr Tyr Phe Leu Arg Asn Ala His Arg Asn 
        835                 840                 845             


Met Met Ala Lys Thr Arg Ser Tyr Met Arg Asp Gln Lys Gly Gln Asp 
    850                 855                 860                 


Gly Thr Leu Ile Glu Gly Leu Ala His Arg Tyr Arg Lys Thr Leu Gln 
865                 870                 875                 880 


Leu Pro Asp Gly Leu Phe Thr Asn Ala Ile Arg Glu Gln Leu Ala Lys 
                885                 890                 895     


Ile Asn Asn Ser Asp Ile Gln Asp Ala Leu Asn Asn Pro Gln Phe Gly 
            900                 905                 910         


His Ser Ala Ala Tyr Leu Leu Asn Leu Trp Phe Thr Lys Ile Ile Gly 
        915                 920                 925             


Asp Gln Ser Gln Pro Phe Tyr Arg Ser Asp Thr His Gly His Tyr Lys 
    930                 935                 940                 


Arg His Tyr Lys Leu Leu Glu Thr Leu Tyr Pro Gln Lys Thr Pro Leu 
945                 950                 955                 960 


Asp Asp Ala Thr Leu Ser Ala Lys Leu Lys Gly Gly Lys Asn Ser Glu 
                965                 970                 975     


Ile Lys Gln Glu Ile Asp Lys Gln Ala Pro Val Ala Lys Lys Glu Ala 
            980                 985                 990         


Glu His Gln Lys Leu Met His Leu  Leu Arg Asp Leu Gln  Arg Asn Glu 
        995                 1000                 1005             


Arg Thr  Ile Arg Arg Tyr Arg  Asn Gln Asp Met Val  Leu Phe Leu 
    1010                 1015                 1020             


Met Ala  Lys Lys Leu Leu Leu  Ser Gly Gly Ala Pro  Phe Met Asn 
    1025                 1030                 1035             


Arg Ala  Glu Ser Asp Gly Ser  Arg Gln Phe Leu Leu  Gln Asn Ile 
    1040                 1045                 1050             


Val Pro  Ile Gly Val Asn His  Gly Glu Glu Asn Asn  Leu Leu Asn 
    1055                 1060                 1065             


Gln Lys  Val Ser Leu Ser Thr  Arg Ile Thr Leu Leu  Asp Asp Lys 
    1070                 1075                 1080             


Asn Lys  Pro Ile Lys Asp Ser  Glu Lys His Pro Met  Lys Arg Thr 
    1085                 1090                 1095             


Ile His  Gln Lys Glu Ile Lys  Met Lys Asn Tyr Gly  Asp Phe Phe 
    1100                 1105                 1110             


Arg Phe  Leu Tyr Asp Ser Arg  Ile Gly Ile Leu Leu  Ser Gln Leu 
    1115                 1120                 1125             


Pro Asp  Asp Glu Ala Gly Ile  Ala Arg Glu Lys Leu  Glu Lys Glu 
    1130                 1135                 1140             


Leu Asp  Thr Tyr Asp Asn Ser  Arg Thr Asp Ile Phe  Lys Val Ile 
    1145                 1150                 1155             


His Lys  Ile Glu Arg Gln Ile  Ile Glu Glu His Pro  Glu Leu Lys 
    1160                 1165                 1170             


Asn Pro  Asn Ser Gly His Phe  Thr Asn Asp Lys Gly  Thr Pro Tyr 
    1175                 1180                 1185             


Arg Asn  Asn Phe Thr Leu Leu  Leu Thr Leu Ser Ala  Leu Phe Ser 
    1190                 1195                 1200             


Glu Ala  Asp His Asn Leu Asn  Gln Lys Gly Lys Leu  Leu Lys Asp 
    1205                 1210                 1215             


Ile Arg  Asp Ala Phe Cys His  Asn Lys Tyr Ile Glu  Asn Ile Glu 
    1220                 1225                 1230             


Arg Ala  Ile Lys Glu Lys Glu  Glu Arg Glu Leu Pro  Lys Ile Ala 
    1235                 1240                 1245             


Glu Asn  Leu Thr Lys Trp Met  Lys Glu Phe Gly Glu  Gln Ser 
    1250                 1255                 1260         


<210>  2307
<211>  1082
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2307

Met Ala Arg His Asn Ala Tyr Leu Leu Met Thr Asp Ile Asn Thr Arg 
1               5                   10                  15      


Leu Gly Tyr Glu Lys Ala Pro Ala Asp Asp Ala Asp Thr Ile Asn Ile 
            20                  25                  30          


Lys Ala Leu Thr Ile Leu Arg Lys Gly Glu Gln Asn Ile Ser Ala Asp 
        35                  40                  45              


Met Gln Leu Lys Val Ile Arg Glu Leu His Ile His Phe Pro Phe Leu 
    50                  55                  60                  


Lys Thr Met Leu Phe Ala Phe Lys Arg Pro Lys Gly Lys Val Glu Asp 
65                  70                  75                  80  


Arg Glu Leu Gln Lys Met Glu Tyr Ala Pro Ala Asp Tyr Tyr Glu Phe 
                85                  90                  95      


Phe Ala Val Phe Leu Lys Ser Leu Asn Glu Leu Arg Asn Glu Tyr Ser 
            100                 105                 110         


His Ala Ala Pro Gln Lys Thr Asp Phe Pro Gly Ser Leu Leu Tyr Gly 
        115                 120                 125             


Met Arg Leu Thr Phe Asp Ala Ala Val Arg Lys Ala Arg Glu Arg Phe 
    130                 135                 140                 


Ser Tyr Thr Asp Lys Asp Val Asp His Leu Ile Arg Leu Gly Lys Gly 
145                 150                 155                 160 


Gly Lys Glu Arg Ala Ala Phe Asn Tyr Lys Phe Gln Asp Glu Lys Asp 
                165                 170                 175     


Ala Ser Leu Ser Leu Tyr Gly Phe Ser Phe Phe Ile Cys Leu Leu Leu 
            180                 185                 190         


Glu Arg Lys Tyr Ile Thr Leu Phe Thr Gln Lys Leu Tyr Gly Leu Lys 
        195                 200                 205             


Asn Arg Ser Val Arg Lys Tyr Gln Ala Ser Tyr Glu Val Phe Ala Ile 
    210                 215                 220                 


Tyr Gly Ile Ser Leu Pro Arg Ala Arg Tyr Thr Ser Asp Val Gly Glu 
225                 230                 235                 240 


Gly Ala Leu Leu Leu Asp Met Leu Asn Glu Leu Lys Lys Cys Pro Ser 
                245                 250                 255     


Leu Leu Phe Pro Gln Leu Pro Ala Lys Tyr Gln Asp Thr Phe Arg Ile 
            260                 265                 270         


Pro Ile Thr Glu Ile Glu Glu Gly Glu Glu Gln Gln Glu Gly Asp Ser 
        275                 280                 285             


Gly Tyr Val Leu Val Lys Arg His Glu Asp Arg Phe Thr Tyr Phe Ala 
    290                 295                 300                 


Leu Arg Phe Ile Asp Glu Val Lys Trp Phe Ser Ser Leu His Phe Pro 
305                 310                 315                 320 


Ile Asp Leu Gly Asn Tyr His Tyr Tyr Leu Tyr Asn Lys Thr Val Glu 
                325                 330                 335     


Gly Ile Pro Arg Val Ala Ser Leu Trp Glu Lys Val Ile Gly Tyr Gly 
            340                 345                 350         


Arg Phe Pro Asp Tyr Gln Arg Asp Phe Phe Ala Glu Ala Val Pro Gln 
        355                 360                 365             


Asn Trp Arg Val Leu Trp Lys Asn His Glu Gln Leu Ala Ala Asp Glu 
    370                 375                 380                 


Ser Asn Leu Leu Pro Phe Met Pro Arg Thr Thr Pro His Tyr His Leu 
385                 390                 395                 400 


Pro Asp Asp Asn Ile Ser Ile Lys Ile Ala Lys Asp Gly Glu Leu Trp 
                405                 410                 415     


Pro His Leu Glu Phe Lys Gly Asn Asp Lys Ser Leu Asn Lys Gln Lys 
            420                 425                 430         


Ala Lys Glu Gln Pro Asp Leu Gln Ile Ser Lys Tyr Asp Leu Phe Ser 
        435                 440                 445             


Leu Val Phe Tyr Gly Leu Leu Val Gly Ser Asp Arg Val Arg Ser Leu 
    450                 455                 460                 


Ile Glu Asn Lys Leu Ile Asn Tyr Val Ser Met Arg Arg Lys Leu Tyr 
465                 470                 475                 480 


Arg Gln Val Gln Ser Gly Ala Phe Thr Pro Ile Gln Phe Pro Ala Asp 
                485                 490                 495     


Ile Pro Ala Pro Thr His Lys Gly Ile Lys Asp Pro Leu Tyr Asp Lys 
            500                 505                 510         


Arg Lys Ala Leu Leu Asn Thr Lys Leu Ala Ser Ser Gly Tyr Asp Phe 
        515                 520                 525             


Pro Pro Asp Asp Leu Thr Asp Glu Ile Lys Ala Tyr Leu Met Gly Val 
    530                 535                 540                 


Lys Thr Glu Ser Phe Glu Glu Lys Ala Lys Tyr Arg Ile Leu Asp Leu 
545                 550                 555                 560 


Leu Asp Glu Thr Asp Asn Leu Leu Asn Ala Ile Lys Arg Lys Leu Lys 
                565                 570                 575     


Glu Lys Arg Lys Pro Gly Ser Lys Lys Asp Val Glu Ile Lys Ala Gly 
            580                 585                 590         


Ile Leu Ala Asp Phe Leu Ala Arg Asp Ile Leu Met Phe Gln Ala Ala 
        595                 600                 605             


Ile Lys Asp Gly Thr Ala Lys Ala Glu Gly Lys Ala Thr Ser Thr Ile 
    610                 615                 620                 


Tyr Lys Val Leu Gln Ala Lys Leu Ala Leu Tyr Gly Ala Asn Ala Asp 
625                 630                 635                 640 


Thr Ile Arg Gln Thr Phe Ala Ala Cys Asn Leu Ile Gly Gly Arg Asn 
                645                 650                 655     


Pro His Pro Phe Leu Ala Arg Val Val Asp Gln Asn Lys Lys Arg Ile 
            660                 665                 670         


Thr Asp Phe Tyr Val Ala Tyr Leu Asp Ala Arg Met Arg Tyr Leu Glu 
        675                 680                 685             


Gln Cys Glu Gln Asp Lys Lys Tyr Arg Glu Tyr Glu Trp Leu Lys His 
    690                 695                 700                 


Asn Gln Ser Arg Arg Arg Asn Gln Pro Asp Tyr Gly Arg Glu Leu Ala 
705                 710                 715                 720 


Gly Arg Met Leu Glu Ile Pro Ile Val Ile Pro Arg Ala Phe Phe Thr 
                725                 730                 735     


Pro Leu Ile Met Ala Glu Leu Thr Ile Ser Gly Asn Glu Gln Leu Lys 
            740                 745                 750         


Ala Leu Ile Gln Asn Gly Arg Thr His Asn Ser Ser Phe Leu Val Leu 
        755                 760                 765             


Ser Tyr Leu Thr Gln Gln Leu Gly Asp Gly Thr Gln His Phe Tyr Asp 
    770                 775                 780                 


Trp Glu Arg Val Tyr Lys Ile Phe Asp Asn Trp Phe Asp Glu Arg Lys 
785                 790                 795                 800 


Lys Lys Arg Asp Pro Leu Pro Gln Lys Pro Leu Asp Glu Arg Ala Arg 
                805                 810                 815     


Gln Glu Leu Phe Lys Asp Val Tyr Lys Trp Ala Ile Glu Gln Thr Lys 
            820                 825                 830         


Glu Thr Gln Thr Asp Tyr Arg Lys Arg Phe Glu Glu Phe Glu Trp Thr 
        835                 840                 845             


Glu Lys Gln Leu Arg His Val Lys Ile Gln Asp Val Val Thr Phe Leu 
    850                 855                 860                 


Met Cys Asp Tyr Leu Leu Lys Asn Ile Asn Arg Asn Leu Phe Gln Ser 
865                 870                 875                 880 


Glu Gly Arg Phe Phe Leu Lys Asp Ile Gly Glu Gly Gly Ile Leu Asp 
                885                 890                 895     


Thr Thr Met Lys Asn Phe Gly Arg Thr Val Arg Tyr Ser Cys Gln Ser 
            900                 905                 910         


Ile Pro Ser Asp Thr Glu Tyr Ile Ile Ser Gly Glu Thr Arg Ile Tyr 
        915                 920                 925             


Gln Asp Asn Leu Lys Val Lys Asn Val Gly Asp Phe Asn Lys Phe Ile 
    930                 935                 940                 


Lys Asp Arg Arg Leu Asn Asn Leu Leu Ala Phe Leu Lys Lys Glu Gln 
945                 950                 955                 960 


Ile Ala Arg Ala Asp Leu Glu Lys Glu Leu Glu Arg Tyr Asp Met Leu 
                965                 970                 975     


Arg Pro Asp Ile Phe His Ser Ile His Glu Phe Glu Ile Lys Ile Leu 
            980                 985                 990         


Ala Lys Trp Pro Asp Thr Asn Gly  Leu Ser Phe Glu Glu  Ile Leu Gln 
        995                 1000                 1005             


Arg Cys  Ile Lys Glu Asn Ala  Leu Thr Lys Glu Asp  Ala Ala Lys 
    1010                 1015                 1020             


Ile Lys  Thr Ile Arg Asn Ala  Phe Ser His Asn Gln  Tyr Pro Asp 
    1025                 1030                 1035             


Pro Leu  Ala Phe Met Ser Gly  Asn Val Met Asn Glu  Glu Ala Ala 
    1040                 1045                 1050             


Gly Ser  Ser His Val Ala Asp  Tyr Phe Tyr Asn Tyr  Leu Val Ala 
    1055                 1060                 1065             


Ala Leu  Gln Lys Val Lys Ser  Glu Thr Pro Ser Thr  Val Gly 
    1070                 1075                 1080         


<210>  2308
<211>  1152
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2308

Met Glu Asn His Thr Lys Gln Thr Thr Tyr Lys Tyr Asp Glu Ile Ala 
1               5                   10                  15      


Asp Lys His Tyr Phe Ala Gly Phe Phe Asn Leu Ala Trp Asn Asn Ile 
            20                  25                  30          


Glu Ile Val Phe Lys Val Phe Leu Lys Lys Phe Lys Leu Ile Glu Asp 
        35                  40                  45              


Lys Asp Lys Lys Ile Glu Val Asn Pro Leu Ser Phe Val Asp Asn Tyr 
    50                  55                  60                  


Phe Lys Asn Glu Leu Ala Leu Ser Asp Tyr Arg Asp Arg Ile Asp Phe 
65                  70                  75                  80  


Leu Lys Gln Tyr Phe Pro Val Val Gln Tyr Leu Glu Leu Leu Val Ser 
                85                  90                  95      


Lys Asn Asn Asp Leu Glu Lys Cys Ile Gly Glu Glu Lys Glu Asn Lys 
            100                 105                 110         


Arg Arg Glu Cys Phe Arg Ala Lys Phe Lys Ser Leu Ile Arg Thr Ile 
        115                 120                 125             


Asn Glu Leu Arg Asn Tyr Tyr Thr His His Tyr His Lys Pro Ile Ile 
    130                 135                 140                 


Val Asp Glu Ala Thr Phe Glu Leu Leu Asp Glu Leu Phe Leu Thr Val 
145                 150                 155                 160 


Val Lys Glu Val Lys Arg Tyr Lys Met Lys Gly Glu Pro Ile Arg His 
                165                 170                 175     


Leu Phe Lys Lys Glu Leu Asn Asn Glu Leu Thr Ala Leu Ile Lys Leu 
            180                 185                 190         


Lys Lys Ser Glu Leu Glu Thr Arg Arg Lys Glu Gly Lys Arg Val Asn 
        195                 200                 205             


Asn Asp Pro Val Ser Ile Glu Asn Ala Val Leu Asn Asp Ala Phe Ser 
    210                 215                 220                 


His Leu Leu Leu Gly Glu Lys Lys Val Lys Lys Phe Tyr Gln Ser Lys 
225                 230                 235                 240 


Ser Thr Ser Ser Asn Gln Gln Ser Thr Ile Asn Ile Ser Glu Ser Gly 
                245                 250                 255     


Leu Leu Phe Leu Leu Gly Met Phe Leu His Lys Lys Glu Ser Glu Arg 
            260                 265                 270         


Leu Arg Ser Asn Ile Gln Gly Phe Lys Ala Lys Val Val Arg Asp Pro 
        275                 280                 285             


Glu Lys Pro Ile Asp Phe Lys Asn Asn Ser Leu Lys Tyr Met Ala Thr 
    290                 295                 300                 


His Trp Val Phe Asn His Leu Ala Ala Lys Pro Ile Lys Glu Arg Leu 
305                 310                 315                 320 


Asn Thr Ala Phe Gln Lys Glu Thr Leu Leu Leu Gln Ile Ala Asp Glu 
                325                 330                 335     


Leu Ser Lys Val Pro Asp Glu Val Tyr Gln Thr Phe Ser Gln Glu Lys 
            340                 345                 350         


Lys Asn Glu Phe Leu Glu Asp Ile Asn Glu Tyr Phe Lys Thr Gly Asn 
        355                 360                 365             


Asp Ile Lys Ser Phe Glu Glu Ser Arg Val Val His Pro Val Ile Arg 
    370                 375                 380                 


Lys Arg Tyr Glu Asn Lys Phe Asn Tyr Phe Val Leu Arg Phe Leu Asp 
385                 390                 395                 400 


Glu Phe Ile Asp Phe Pro Thr Leu Arg Phe Gln Ile His Leu Gly Asn 
                405                 410                 415     


Tyr Val His Asp Gln Lys Glu Lys Pro Ile Ser Gln Gly Thr His Leu 
            420                 425                 430         


Ile Thr Gln Arg Ile Ile Lys Glu Lys Ile Asn Leu Phe Gly Lys Leu 
        435                 440                 445             


Ser Glu Val Thr Asn Asn Lys Thr Asp Phe Phe Gln Lys Leu Glu Val 
    450                 455                 460                 


Ala Gly Gly Glu Thr Asn Leu Glu Met Phe Pro Glu Pro Ser Tyr Asn 
465                 470                 475                 480 


Phe Val Gly Asn Asn Ile Pro Ile Tyr Leu Asn Leu Ala Lys Ser Lys 
                485                 490                 495     


Val Glu Gly Ala Lys Glu Leu Asn Ser His Leu Ile Arg Leu Asn Asn 
            500                 505                 510         


Glu Glu Lys Lys His Gln Lys Lys Arg Thr Gly Asn Lys Pro Asp Lys 
        515                 520                 525             


Thr Ile Gln Ile Ser Gly Ile Ser Tyr Gly Lys Pro Val Ala Leu Leu 
    530                 535                 540                 


Ser Leu Asn Glu Leu Pro Ala Leu Leu Tyr Glu Leu Leu Ile Asn Gly 
545                 550                 555                 560 


Lys Ser Gly Glu Glu Ile Glu Asn Ile Leu Val Glu Lys Leu Val Ala 
                565                 570                 575     


Arg Tyr Lys Thr Ile Asn Asn Phe Ser Pro Asp Asn Pro Leu Pro Thr 
            580                 585                 590         


Ser Gln Ile Ser Lys Lys Leu Arg Lys Ala Thr Ala Asn Glu Arg Ile 
        595                 600                 605             


Asp Ile Asp Lys Leu Ile Arg Ala Ile Asp Arg Glu Ile Ala Val Ser 
    610                 615                 620                 


Lys Glu Lys Ala Asn Leu Ile Ala Thr Lys Leu Arg Asp Trp Glu Asn 
625                 630                 635                 640 


Ala Lys Thr Asn Arg Lys Tyr Ala Phe Thr Lys Lys Glu Leu Gly Gln 
                645                 650                 655     


Glu Ala Thr Trp Leu Ala Asp Asp Ile Lys Arg Phe Met Pro Asn Lys 
            660                 665                 670         


Val Lys Glu Asn Trp Lys Gly Tyr Gln His Ser His Leu Gln Leu Leu 
        675                 680                 685             


Leu Ala Phe Tyr Glu Ser Arg Pro Asn Glu Ala Tyr Ser Phe Ile Gln 
    690                 695                 700                 


Glu Phe Trp Asn Leu Asp Asn Asp Thr Tyr Leu Phe Asn Arg Trp Leu 
705                 710                 715                 720 


Lys Thr Ser Phe Tyr Glu Lys Ser Phe His Lys Phe Tyr Gln Lys Tyr 
                725                 730                 735     


Leu Glu Asn Arg Lys Glu Tyr Phe Glu Asn Ile Arg His Gln Ile Thr 
            740                 745                 750         


Ala Phe Lys Asn Gln Glu Lys Leu Leu Lys Lys Phe Ile Glu Gln Gln 
        755                 760                 765             


His Ile Trp Ser Val Phe Tyr Lys Arg Leu Tyr Ile Val Ser Pro Ile 
    770                 775                 780                 


Glu Glu Gln Lys Arg Gln Leu Leu Leu Lys Pro Leu Val Phe Thr Arg 
785                 790                 795                 800 


Gly Ile Phe Asp Pro Lys Pro Thr Tyr Ile Glu Gly Lys Glu Phe Glu 
                805                 810                 815     


Gly Asn Lys Asp Leu Phe Ala Asp Trp Tyr Gln Tyr Ile His Asp Lys 
            820                 825                 830         


Glu His Val Leu Gln Lys Phe Tyr Ser Trp Lys Arg Asp Tyr Lys Glu 
        835                 840                 845             


Leu Phe Glu Lys Phe Lys Ala Ser Asp Glu Phe Thr Asn Asn Lys Tyr 
    850                 855                 860                 


Gln Leu Ser Glu Lys Gln Gln Phe Glu Leu Phe Asn Arg Lys Trp Asp 
865                 870                 875                 880 


Lys Lys Ile Arg Lys Ile Ile Gly Gln Asp Leu Phe Leu Asn Leu Ile 
                885                 890                 895     


Ile Lys Arg Ile Ile Lys Glu Leu Tyr His Gln Asp Val Ala Leu Asn 
            900                 905                 910         


Leu Ala Asp Tyr Tyr Leu Thr Gln Glu Glu Arg Ile Glu Lys Glu Gln 
        915                 920                 925             


Arg Ala Lys Gln Gln Thr Asn Arg Leu Lys Gly Asp Lys Ser Glu Asn 
    930                 935                 940                 


Ile Ile Asn Asp Ser Phe Ile Trp Asn Met Thr Ile Ser Tyr Lys Thr 
945                 950                 955                 960 


Asp Tyr Ile Asn Glu Pro Ala Ile Lys Leu Lys Asp Ile Gly Lys Phe 
                965                 970                 975     


Ile Arg Phe Leu Asn Asp Glu Lys Val Glu Arg Ile Phe Ser Tyr Thr 
            980                 985                 990         


Pro Lys Lys Asn Asn Trp Arg Lys  His Glu Ile Glu Lys  Glu Leu Glu 
        995                 1000                 1005             


Met Tyr  Glu Lys Ile Arg Arg  Glu Glu Val Phe Lys  Met Ile Gln 
    1010                 1015                 1020             


Glu Leu  Glu Lys Lys Ile Leu  Glu Lys His Lys Phe  Asp Gly Ile 
    1025                 1030                 1035             


Asn His  Pro Asp Glu Phe Glu  Lys Ser Gly Asn Pro  Asn Phe Lys 
    1040                 1045                 1050             


Lys Tyr  Ile Thr Gln Gly Val  Leu Lys Lys Arg Gly  Ile Gln Asp 
    1055                 1060                 1065             


Val Val  Ile Glu Trp Ile Glu  Asn Leu Gly Glu Asn  Ser Tyr Glu 
    1070                 1075                 1080             


Asp Asn  Asp Thr Leu Glu Leu  Leu Val Gln Lys Asp  Glu Lys Val 
    1085                 1090                 1095             


Gln Asp  Ala Phe Leu Leu Ile  Tyr Leu Arg Asn Lys  Phe Ala His 
    1100                 1105                 1110             


Asn Gln  Leu Pro Thr Lys Glu  Ile Phe Asp Ile Ile  Val Ser Lys 
    1115                 1120                 1125             


Thr Asp  Thr Lys Ser Tyr Val  Ala Glu Thr Leu Leu  Asn Tyr Ile 
    1130                 1135                 1140             


Ser Ile  Thr Ser Arg Arg Ile  Leu Asn 
    1145                 1150         


<210>  2309
<211>  1147
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2309

Met Gln Leu Thr Asn Ala Lys Asn Tyr Leu Ser Gln Gln Val Asp Arg 
1               5                   10                  15      


Glu Asn Ile Arg Ala Arg Phe Ala Glu Ile Phe His Arg Lys Gly Val 
            20                  25                  30          


Met Ala Ala Ile Ala Asn Lys Ala Phe Arg Asn Leu Glu Leu Lys Lys 
        35                  40                  45              


Glu Arg Ala Gly Lys Glu Ser Asp Asp Asn Gly Ile Tyr His Tyr Phe 
    50                  55                  60                  


Leu Ile Gly His Leu Phe Lys His Ile Asp Thr Lys Ala Phe Phe Ala 
65                  70                  75                  80  


Ser Val Leu Asn Ala Asp Glu Thr Lys Gln Val Pro Ser Arg Phe Arg 
                85                  90                  95      


Ala Leu Gln Ser Phe Glu Phe Asp Phe Gly Pro Asp Phe Phe Thr Leu 
            100                 105                 110         


Leu Lys Ser Val Arg Asn Val Asn Ser His Tyr Ile His Thr Phe Asp 
        115                 120                 125             


Cys Leu Arg Val Asp Arg Leu Thr Pro Lys Leu Trp Lys Phe Ile Arg 
    130                 135                 140                 


Glu Ala Phe Glu Leu Ser Ser Ile Leu Ser Phe Ile Asn Glu Tyr Glu 
145                 150                 155                 160 


Met Ser Ala Ala Ala Tyr Phe Glu Asp Asp Met Arg Glu Glu Lys Leu 
                165                 170                 175     


Ile Ala Phe Trp Cys Asp Lys Phe Phe Pro Asn Thr Val Tyr Gln Ser 
            180                 185                 190         


Thr Val Arg Lys Ser Phe Gly Asn Leu Thr Lys Ser Lys Ala Ile Asp 
        195                 200                 205             


Phe Leu Leu Thr Ile Asp Val Asp Thr Pro Ile Thr Trp Glu Leu Ser 
    210                 215                 220                 


Pro Gly His Gln Leu Phe Thr Ile Asp Ser Gly Arg Tyr Leu Ser Phe 
225                 230                 235                 240 


His Ala Thr Met Val Val Ile Ser Leu Ser Leu Tyr Lys Asn Glu Ala 
                245                 250                 255     


Asn Gln Leu Ile Ser Lys Ile Lys Gly Phe Lys Arg Asn Asp Asp Asn 
            260                 265                 270         


Ala Tyr Lys Ser Lys Arg Arg Ile Phe Thr Glu Leu Ser Lys Arg Phe 
        275                 280                 285             


Ser Ser Gln Asp Asn Asp His Glu Gln Leu His Leu Val Lys Phe Arg 
    290                 295                 300                 


Asp Ile Ile Gln Tyr Leu Asn His Tyr Pro Thr Pro Trp Ser Glu Met 
305                 310                 315                 320 


Leu Glu Pro Asp Lys His Pro Asp Ala Ala Ala Arg Ser Leu Lys Glu 
                325                 330                 335     


Ser Ile Val Asp Met Glu Ile Arg Arg Leu Tyr Pro Glu Val Phe Ile 
            340                 345                 350         


Thr Gly Ser Asn Glu Glu Gln Glu Arg Phe Ala Ile Tyr Ala Arg Tyr 
        355                 360                 365             


Arg Leu Phe Gly Glu Val Ile Lys Gly Arg Tyr Lys Lys Ser Phe Ile 
    370                 375                 380                 


Ser Ala Asn Phe Ser Ser Ala Glu Ser Gly Lys Phe Glu Asp Val Ile 
385                 390                 395                 400 


Tyr Thr Ser Asp Glu Val Lys Gly Leu Arg Arg Lys Leu Ala Asp Leu 
                405                 410                 415     


Arg Asn Ala Gln Val Ile Asp Gly Arg Arg Arg Lys Glu Ile Glu Lys 
            420                 425                 430         


Val Lys Arg Ala Leu Ala Asp Ala Lys Ser Leu Pro Asn Gln Glu Val 
        435                 440                 445             


Glu Lys Leu Ala Asn Arg Leu His Ser Gly Leu Phe Phe Ile Ser Tyr 
    450                 455                 460                 


Gly Arg Asn Gln Asp Arg Phe Met Glu Phe Ala Leu Arg Tyr Leu Leu 
465                 470                 475                 480 


Glu Ala Ala Tyr Phe Gly Pro Glu Ala Lys Ala Cys Ser Tyr Gln Phe 
                485                 490                 495     


Tyr Thr Thr Glu Glu Gln Gln Asp Phe Leu Ala Asn Ala Lys Asn Ser 
            500                 505                 510         


Ser Pro Lys Ala Thr Tyr Asp Lys Leu Lys Phe His His Gly Lys Ser 
        515                 520                 525             


Val His Phe Ile Thr Tyr Ala Asp His Leu Lys Lys Tyr Pro Asp Trp 
    530                 535                 540                 


Asp Thr Pro Phe Val Val Arg Asn Asn Ala Val Gln Val Glu Val Pro 
545                 550                 555                 560 


Ile Asp Leu Glu Gly Pro Gln Gly His Pro Val Tyr Lys Val Leu Thr 
                565                 570                 575     


Ile Gln Arg Ala Val Met Pro Tyr Leu Leu Ala His Ala Met Tyr His 
            580                 585                 590         


Ala Glu Arg Gly Thr Pro Ala Gly Gln Lys Leu Ile Ser Ala Phe Tyr 
        595                 600                 605             


Met Arg Tyr His Ser Gln Ile Glu Ala Asp Met Thr Phe Leu Ser Glu 
    610                 615                 620                 


Arg Thr Ala Ile Thr Ser Ile Glu Lys Ser Arg Leu Lys Lys Arg Phe 
625                 630                 635                 640 


Pro Lys Arg Leu Leu His Asn Tyr His Gly Gly Ser Asn Pro Gln Pro 
                645                 650                 655     


Tyr Thr Thr Pro Leu Arg Ala Leu Leu Glu Asp Ala Asn Ala Gln Glu 
            660                 665                 670         


Glu Arg Tyr Ala Leu Leu Leu Ala Glu Ala Lys Lys Lys Gly Ile Gly 
        675                 680                 685             


Ala Glu Phe Thr Lys Arg Asn Lys Gly Lys Gln Phe Lys Leu Arg Phe 
    690                 695                 700                 


Leu Arg Arg Ala Trp His Glu Leu Tyr Phe Lys Lys Ser Tyr Ala Arg 
705                 710                 715                 720 


Gln Val Ala Leu His Asp Gly Gln His His Lys Ser Phe His Ile Thr 
                725                 730                 735     


Arg Asp Glu Phe Asn Asp Phe Ser Arg Trp Met Phe Ala Phe Asp Glu 
            740                 745                 750         


Val Pro Gln Tyr Lys His Gln Leu Glu Lys Leu Phe Ser Ala Lys Gly 
        755                 760                 765             


Phe Phe His Ile Thr Ser Phe Arg Ser Leu Phe Asp Ser Gly Arg Ser 
    770                 775                 780                 


Leu Glu Asp Phe Tyr Tyr Lys Thr Lys Gln Ile Phe Lys Thr Trp Leu 
785                 790                 795                 800 


Glu Glu Glu Ser Lys Lys Ser Ala Val Pro Lys Leu Arg Asp Leu Ser 
                805                 810                 815     


Ala Phe Lys Gln Gln Ile Asp Arg Pro Asp Leu Phe Ile Asn Leu Ser 
            820                 825                 830         


Glu Phe Ile Asn Phe Leu Ile Asp Thr Gly Thr Leu Ser Lys Asp Ala 
        835                 840                 845             


Ser Gly His Ile Gln Tyr His Cys Ala Ser Asn Phe Pro Phe Leu His 
    850                 855                 860                 


Ser His Phe Tyr Glu Val Ser Thr Leu Ser Gly Ala Ser Ala Thr Phe 
865                 870                 875                 880 


Arg Lys Arg Ile Gly Lys His Arg Leu Glu Asp Ala Leu Leu Tyr Glu 
                885                 890                 895     


Ile Ala Met His Tyr Leu Lys Met Asp Thr Gln Val Ile Gln His Ala 
            900                 905                 910         


Arg His His Val Gly Val Ile Gln Gln Glu Asp Val Glu Leu Asp Leu 
        915                 920                 925             


Lys Asp Ser Lys Gly Asn Gly Leu Tyr Lys Leu Ser Ile Pro Phe His 
    930                 935                 940                 


Lys Ile Ser Ala Phe Thr Glu Leu Leu Thr His Lys Ala Lys Gln Glu 
945                 950                 955                 960 


Ala Asn Pro Arg Phe Arg Asn Ser Ser Phe Leu Gly Asn Leu Lys Glu 
                965                 970                 975     


Tyr Ile Asn Leu Ala Gln Asp Glu Lys Glu Val Lys Pro Ile Cys Gln 
            980                 985                 990         


Val Leu Ala Arg Thr Gly Thr Leu  Phe Tyr Asp Asp Leu  His Lys Ile 
        995                 1000                 1005             


Asn Gly  His Leu Val Ser Gln  Ser Ile Gln Phe Thr  Gln Val Val 
    1010                 1015                 1020             


Met Ala  Leu Glu Arg Tyr Phe  Ile Ser Lys Gly Gly  Val Ser Leu 
    1025                 1030                 1035             


Phe Asn  Lys Asp Tyr Ile Asp  Phe Ser Lys Leu Pro  Ile Leu Met 
    1040                 1045                 1050             


Gly Tyr  Phe Glu Asn Lys Lys  Glu Thr Arg Asn Lys  Ala Phe His 
    1055                 1060                 1065             


Phe Asp  Val Pro Lys Gln Thr  Tyr Arg Ser Leu Ile  Phe Asp Ile 
    1070                 1075                 1080             


Glu Lys  Lys Phe Ile Thr Asn  Glu Val Lys Pro Val  Gly Ala Lys 
    1085                 1090                 1095             


Lys Trp  Gln Asp Leu Pro Ile  Glu Ile Arg Ala Ile  Leu Glu Leu 
    1100                 1105                 1110             


Phe Leu  Asn Gln Leu His Glu  His Phe Phe Gly Arg  Lys Ala Thr 
    1115                 1120                 1125             


Asp Gly  Val Asn Arg Arg Arg  Gln Ala Glu Asp Lys  Tyr Met Asn 
    1130                 1135                 1140             


Glu Val  Val Asn 
    1145         


<210>  2310
<211>  1090
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2310

Met Glu Asp Asp Lys Lys Thr Lys Glu Ser Thr Tyr Thr Leu Asp Asn 
1               5                   10                  15      


Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val Tyr 
            20                  25                  30          


Ile Thr Val Asn His Ile Asn Lys Ile Leu Gly Glu Gly Glu Ile Asn 
        35                  40                  45              


Arg Asp Gly Tyr Glu Lys Thr Ile Glu Asn Ala Trp Asn Glu Ile Lys 
    50                  55                  60                  


Asp Ile Asn Lys Lys Asp Arg Leu Ser Lys Leu Ile Ile Lys His Phe 
65                  70                  75                  80  


Pro Phe Leu Glu Val Thr Thr Tyr Gln Gln Asn Ser Ala Asp Thr Thr 
                85                  90                  95      


Lys Gln Lys Glu Glu Lys Gln Ala Glu Ala Gln Ser Leu Glu Ser Leu 
            100                 105                 110         


Lys Lys Ser Phe Phe Val Phe Ile Tyr Lys Leu Arg Asp Leu Arg Asn 
        115                 120                 125             


His Tyr Ser His Tyr Lys His Ser Lys Ser Leu Glu Arg Pro Lys Phe 
    130                 135                 140                 


Asp Lys Asp Phe Arg Asn Lys Leu Tyr Asn Ile Phe Asp Ala Ser Ile 
145                 150                 155                 160 


Arg Leu Val Lys Glu Asp Tyr Lys His Asn Pro Asp Ile Lys Pro Lys 
                165                 170                 175     


Glu His Phe Lys His Leu Asp Arg Lys Arg Lys Glu Glu Phe Arg Tyr 
            180                 185                 190         


Ser Phe Ala Asp Asn Glu Gly Asn Ile Thr Ile Ser Gly Leu Leu Phe 
        195                 200                 205             


Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Val Gln Lys 
    210                 215                 220                 


Lys Phe Glu Gly Phe Arg Cys Ser Asn Glu Ser Tyr Gln Lys Met Thr 
225                 230                 235                 240 


Asn Glu Val Phe Cys Arg Asn Arg Ile Leu Met Pro Lys Leu Arg Leu 
                245                 250                 255     


Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu Asn Glu 
            260                 265                 270         


Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Lys Gly Glu Asp 
        275                 280                 285             


Arg Lys Asn Phe Glu Val Pro Phe Asp Ser Thr Asp Glu Asp Tyr Asp 
    290                 295                 300                 


Ala Glu Gln Asp Pro Phe Lys Asn Thr Leu Ile Arg His Gln Asp Arg 
305                 310                 315                 320 


Phe Pro Tyr Phe Val Leu Arg Tyr Phe Asp Tyr Asn Glu Ile Phe Glu 
                325                 330                 335     


Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile Tyr 
            340                 345                 350         


Lys Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg His Leu Thr His Lys 
        355                 360                 365             


Leu Tyr Gly Phe Glu Arg Leu Gln Glu Phe Ala Lys Gln Asn Arg Pro 
    370                 375                 380                 


Asp Glu Trp Lys Ser Ile Ile Lys Asp Leu Asp Thr Phe Lys Lys Gln 
385                 390                 395                 400 


Glu Asp Glu Glu Val Asn Glu Lys Pro Tyr Ile Ser Glu Thr Thr Pro 
                405                 410                 415     


His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Ala Phe Lys Asn His 
            420                 425                 430         


Asn Ile Trp Pro Thr Thr Lys Thr Glu Leu Thr Asn Asn Lys Arg Lys 
        435                 440                 445             


Lys Tyr Asn Leu Gly Thr Ser Ile Lys Ala Glu Ala Phe Leu Ser Val 
    450                 455                 460                 


His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Lys Thr Lys 
465                 470                 475                 480 


Asn Glu Ser Pro Arg Lys Val Glu Ala Ile Ile Glu Ser Lys Ile Lys 
                485                 490                 495     


Asp Ile Phe Thr Leu Tyr Asp Ala Phe Ala Asn Asp Glu Ile Asp Asn 
            500                 505                 510         


Thr Asp Lys Leu Glu Lys Tyr Cys Glu Asp Lys Asp Ile Lys Ile Gly 
        515                 520                 525             


His Leu Pro Lys Gln Met Ile Ala Ile Leu Tyr Asn Lys His Lys Asp 
    530                 535                 540                 


Met Val Glu Lys Ala Lys Val Lys Gln Glu Lys Met Lys Leu Asp Thr 
545                 550                 555                 560 


Glu Asp Arg Leu Lys Lys Ile Asp Lys Gln Ile Glu Gly Lys Ile Lys 
                565                 570                 575     


Tyr Thr Lys Arg Gly Lys Ser Pro Leu Lys Ser Gly Glu Ile Ala Ser 
            580                 585                 590         


Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln Arg Asp Glu 
        595                 600                 605             


Asn Gly Glu Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln 
    610                 615                 620                 


Leu Leu Gln Arg Thr Leu Ala Leu Phe Gly Ser Glu His Glu Arg Leu 
625                 630                 635                 640 


Thr Pro Tyr Phe Lys Gln Met Asn Leu Ile Gly Asp Thr Asn Ser His 
                645                 650                 655     


Pro Phe Leu Lys Gln Thr Glu Trp Glu Lys Cys Asn Asn Ile Leu Ser 
            660                 665                 670         


Phe Tyr Arg Asn Tyr Leu Lys Ala Lys Ile Glu Phe Leu Asp Lys Leu 
        675                 680                 685             


Lys Pro Glu Asp Trp Lys Lys Asn Gln Tyr Phe Leu Lys Leu Lys Glu 
    690                 695                 700                 


Pro Lys Thr Asn Cys Lys Thr Leu Val Gln Gly Trp Lys Asn Gly Phe 
705                 710                 715                 720 


Asn Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg Lys Trp Phe Met 
                725                 730                 735     


Glu His Gln Lys Ser Ile Lys Val Asp Asp Leu Lys Arg Val Gly Leu 
            740                 745                 750         


Val Ala Lys Val Ile Pro Leu Tyr Phe Asn Lys Ile Tyr Lys Asp Ser 
        755                 760                 765             


Val Gln Pro Phe Tyr Asn Tyr Pro Phe Asn Val Gly Asp Ile Asn Lys 
    770                 775                 780                 


Pro Lys Glu Lys Asp Phe Leu Asp Asn Glu Lys Arg Arg Lys Leu Trp 
785                 790                 795                 800 


Asp Lys Lys Gln Leu Glu Phe Lys Gly Lys Thr Glu Glu Glu Lys Arg 
                805                 810                 815     


Lys Asn Pro Ser Tyr Leu Asp Phe Lys Ser Trp Lys Lys Phe Glu Arg 
            820                 825                 830         


Glu Leu Arg Leu Ile Lys Asn Gln Asp Ile Ile Thr Trp Leu Met Cys 
        835                 840                 845             


Ile Glu Leu Tyr Asn Asn Gln Lys Val Glu Asn Leu Asn Thr Gly His 
    850                 855                 860                 


Ile Tyr Leu Lys Asp Ile Ile Thr Asn Val Lys Glu Glu Arg Asn Asn 
865                 870                 875                 880 


Asn Ile Leu Asn Gln Ile Lys Ser Met Gln Leu Pro Val Thr Val Tyr 
                885                 890                 895     


Glu Asn Glu Ser Ser Pro Lys Lys Lys Tyr Leu His Thr Ile Tyr Ile 
            900                 905                 910         


Glu Glu Asn Gly Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu 
        915                 920                 925             


Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Val Lys Thr Asn 
    930                 935                 940                 


Ser Glu Ala Glu Ser Lys Ser Asn Pro Ile Ser Lys Leu Cys Val Glu 
945                 950                 955                 960 


His Glu Leu Arg Glu Tyr Gln Lys Ala Arg Ile Glu Ile Ile Lys Asp 
                965                 970                 975     


Met Leu Ala Leu Glu Lys Thr Leu Ile Asp Asn Tyr Asp Ser Leu Asp 
            980                 985                 990         


Thr Asp Asn Phe His Asn Met Leu  Thr Gly Trp Leu Glu  Leu Lys Gly 
        995                 1000                 1005             


Glu Val  Asn Lys Ala Lys Phe  Asn Asn Asp Val Lys  Leu Leu Thr 
    1010                 1015                 1020             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1025                 1030                 1035             


Glu Asn  Leu Phe Gly Asn Ile  Glu Arg Phe Ser Leu  Ser Ser Ser 
    1040                 1045                 1050             


Thr Ile  Leu Glu Ser Lys Gly  Leu Asn Ile Ala Ala  Lys Leu Lys 
    1055                 1060                 1065             


Glu Glu  Val Ser Lys Thr Val  Glu Lys Ile Gln Glu  Glu Glu Asp 
    1070                 1075                 1080             


Gly Lys  Lys Glu Lys Glu Thr  
    1085                 1090 


<210>  2311
<211>  1270
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2311

Met Asn Leu Leu Thr Lys Asn Asn Thr Ile Met Gly Asn Tyr Gln Gln 
1               5                   10                  15      


Asn Trp Lys Lys Arg Arg Thr Ala Pro Gln Pro Asn Ala Lys Ser Glu 
            20                  25                  30          


Gln Leu Arg Pro Val Phe Ala Ala Tyr Leu Asn Met Ala Arg Ala Asn 
        35                  40                  45              


Leu Tyr Ser Val Leu Arg Tyr Ile Ser Val Gln Cys Gly Leu Glu Val 
    50                  55                  60                  


Asn Gln Asn Glu Asp Ser Met His Glu Leu Pro Ile Ala Lys Phe Ala 
65                  70                  75                  80  


Ser Asn Lys Arg Pro Glu Val Arg Gln Lys Ala Phe Leu Leu Leu Met 
                85                  90                  95      


Arg Asn Ile Pro Ile Leu Gln Gln Met Thr Gln Ser Gly Leu Thr Gln 
            100                 105                 110         


Gly Lys Pro Ala Asp Gly Asp Arg Pro Ala Lys Glu Lys His Leu Ala 
        115                 120                 125             


Val Glu Gln Glu Asp Leu Gln Arg Val Leu Gln Asn Leu Ile Arg Val 
    130                 135                 140                 


Val Asn Phe Lys Arg Asn Leu Phe Thr His Ala Asp His Tyr Asp Thr 
145                 150                 155                 160 


Asp Glu Glu Ile Glu Lys Glu Leu Gln Arg Glu Val Ala Leu Ser Gly 
                165                 170                 175     


Pro Leu Asn Thr Ala Phe Lys Gly Ser Lys Arg Glu Val Lys Arg Ile 
            180                 185                 190         


Phe Cys Tyr Thr Glu Lys Asp Met Asn Phe Val Asp Gln Asp Glu His 
        195                 200                 205             


Met Lys Arg Ile Leu Met Lys Asp Lys Asn Gly Asn Ile Met Gln Asp 
    210                 215                 220                 


Glu Lys Gly Lys Asp Met Tyr Ile Phe Val Glu Arg Ser Asn Trp Tyr 
225                 230                 235                 240 


Phe Arg Leu Tyr Asp Thr Thr Pro Asp Pro Val Thr Glu Met Pro Leu 
                245                 250                 255     


Ala Gln Lys Leu Thr Thr Ala Gly Leu Val Phe Ile Leu Cys Lys Leu 
            260                 265                 270         


Leu His Lys Lys Tyr Ala Thr Gln Leu Val Gln Lys Thr Gly Leu Phe 
        275                 280                 285             


Arg Thr Arg Ala Gln Ser Gly Ser Ser Pro Phe Glu Lys Asn Glu Asn 
    290                 295                 300                 


Glu Val Met Phe Asn Ile Phe Cys Ala His Arg Ile Arg Leu Pro Lys 
305                 310                 315                 320 


Gly Arg Val Glu Ser Thr Ala Ser Asp Tyr Ala Leu Gly Leu Asp Ile 
                325                 330                 335     


Leu Asn Glu Leu Gln Lys Cys Pro Ser Glu Leu Phe Asp Thr Leu Ser 
            340                 345                 350         


Pro Asp Asp Lys Glu Leu Phe Gln Phe Lys Lys Lys Asp Asn Glu Thr 
        355                 360                 365             


Leu Ser Ser Pro Asp Asp Asp Ile Asn Leu Phe Arg Arg Tyr Gly Asp 
    370                 375                 380                 


Arg Phe Pro Tyr Leu Ala Met His Tyr Ile Asp Ala Met Arg Glu Ala 
385                 390                 395                 400 


His Asp Asn Gln Ser Lys Val Leu Arg Asp Ile Val Phe Gln Val Ser 
                405                 410                 415     


Leu Gly Lys Tyr Arg Phe Asn Phe Tyr Asn Arg Ala Ser Leu Asp Thr 
            420                 425                 430         


Asn Val Glu Asp Arg Val Arg Val Trp Gln Lys Glu Ile Asn Gly Phe 
        435                 440                 445             


Gly Pro Ile Asp Lys Ile Glu Gln Lys Arg Lys Asp Glu Tyr Gly Ala 
    450                 455                 460                 


Ile Ile Arg Pro Ile Ser Asp Asp Pro Lys Arg Leu Tyr Asn Ala Asp 
465                 470                 475                 480 


Thr Ala Glu Thr Glu Pro Tyr Leu Thr Asp Gln His Ala Ala Tyr Ala 
                485                 490                 495     


Ile Thr Gly Asn Arg Ile Gly Ile Thr Trp Asn Asp Leu Ile Gln Asn 
            500                 505                 510         


Pro His Ser Asp Glu Arg Arg Ser Ser Ile Arg Leu Arg Trp Pro Glu 
        515                 520                 525             


Lys Glu Lys Lys Gly Glu Asp Arg Gln Lys Asp Lys Ile Asn Ile Glu 
    530                 535                 540                 


Lys Leu Asp Asn Asp Lys Cys Phe Leu Pro Asn Val Pro Glu Ser Thr 
545                 550                 555                 560 


Glu Asn Val Ala Pro Arg Ala Trp Leu Ser Ile Tyr Asp Leu Pro Ala 
                565                 570                 575     


Leu Ile Phe Leu His Leu Leu Gly Gly Asp Pro Glu Ala Val Ile Lys 
            580                 585                 590         


Asp Thr Tyr Lys Arg Leu Val Leu Leu Phe Asp Asp Ile Arg Thr Asp 
        595                 600                 605             


Gln Leu Lys Pro Gln Ala Asn Lys Glu Gln Leu Gln Asn Val Leu Ser 
    610                 615                 620                 


Ser Asp Pro Tyr Lys Leu Arg Leu Ser Asp Ile Pro Lys Lys Leu Gln 
625                 630                 635                 640 


Asn Tyr Leu Ser Ser Lys Gly Pro Lys Thr Gln Asp Glu Ala Asp Lys 
                645                 650                 655     


Ala Phe Ile Asn Trp Val Asn Glu Gln Leu Asp Gly Asp Gly Leu Glu 
            660                 665                 670         


Val Gly Ile Ile Glu Lys Leu Arg Leu Arg Ile Glu Gln Phe Lys Gln 
        675                 680                 685             


Asn Leu Lys Val Val Gly Asp Lys Gln Asn Arg Ile Gly Arg Lys Gly 
    690                 695                 700                 


Tyr Val Asp Ile Arg Pro Gly Ser Leu Ala Arg Tyr Ile Ser Lys Asp 
705                 710                 715                 720 


Ile Met Leu Met Thr Arg Pro Asp Glu Ser Arg Lys Asn Asn Gly Lys 
                725                 730                 735     


Pro Ser Gly Leu Asp Tyr Gly Val Leu Gln Ala Ala Ile Ala Thr Phe 
            740                 745                 750         


Lys Gly Asp Gly Asn Ala Leu Ala Asn Thr Ser Leu Gly Arg Met Leu 
        755                 760                 765             


Leu Lys Ala Ile Asn Val Asn Asn His Pro Phe Leu Asn Ser Val Met 
    770                 775                 780                 


Gly Gln Gln Ile Ser Asp Thr Ile Asp Phe Tyr Thr Lys Tyr Gln Ile 
785                 790                 795                 800 


Ala Lys Leu Glu Tyr Leu Asn Ala Leu Arg Lys Gly Lys Arg Gly Asp 
                805                 810                 815     


Tyr Lys Glu Gln Trp Phe Leu Arg Glu Ala Tyr Arg Asn His Ala Val 
            820                 825                 830         


Gln Thr Ala Glu His Met Gln Gly Glu Lys Gly Leu Ala Ser Leu Tyr 
        835                 840                 845             


Ile Asp Thr Leu Gln Leu Pro Asp Gly Leu Phe Thr Asp Ala Ile Tyr 
    850                 855                 860                 


Asn Gln Leu Leu Ala Asn Asn Val Thr Ala Asn Asn Ala Glu Val Arg 
865                 870                 875                 880 


Ala Ala Leu Ala Asp Arg Glu Lys Ser Gly Gly Val Ser His Leu Ile 
                885                 890                 895     


Asn Leu Tyr Phe Glu Lys Val Leu Gly Asp Lys Pro Gln Ser Phe Tyr 
            900                 905                 910         


Arg Glu Met Lys Arg His Tyr Lys Val Ile Asp Trp Ala Lys Tyr Glu 
        915                 920                 925             


Gln Asp Lys Asp His Pro Val Leu Leu Thr Thr Ile Pro Pro Ala Val 
    930                 935                 940                 


Tyr Ser Ser Pro Glu Glu Ile Ser Thr Leu Leu Arg Lys Gly Asn Ser 
945                 950                 955                 960 


Asp Asp Ser Pro Ile Val Arg Lys Leu Asn His Ile Ala Asn Ser Leu 
                965                 970                 975     


Lys Lys Lys Ile Ser Lys Lys Trp Glu Met Pro Pro Arg Tyr Ala Ser 
            980                 985                 990         


Ala Glu Ile Lys Glu Lys Asp Asp  Leu Phe Phe Lys Leu  Ile His Gln 
        995                 1000                 1005             


Met Arg  Lys Leu Gln Lys Asn  Glu Arg Asn Ile Arg  Arg Tyr Arg 
    1010                 1015                 1020             


Asn Gln  Asp Ile Leu Leu Phe  Glu Met Ala Lys Lys  Ile Leu Leu 
    1025                 1030                 1035             


Ser Gly  Gly Val Val Ile Lys  Asp Asn Gly His Val  Glu Arg Gly 
    1040                 1045                 1050             


Ile Asp  Gln Phe Lys Leu His  Asp Ile Leu Pro Pro  Gly Met Lys 
    1055                 1060                 1065             


Arg Gly  Asn Asp Asn Asn Leu  Leu Glu Gln Lys Val  Glu Phe Arg 
    1070                 1075                 1080             


Leu Thr  Ile Asn Leu Asn Asp  Glu Asn Gly Lys Pro  Ile Lys Asp 
    1085                 1090                 1095             


Ser Glu  Gly Asn Ser Leu Thr  Arg Thr Ile Ser Gln  Ala Gly Ile 
    1100                 1105                 1110             


Lys Ile  Lys Asn Tyr Gly Asp  Phe Tyr Thr Phe Leu  Tyr Asp Ser 
    1115                 1120                 1125             


Arg Ile  Gly Ser Leu Leu Ser  Gln Leu Asn Val Asn  Asp Asp Ile 
    1130                 1135                 1140             


Lys Arg  Asp Asn Leu Glu Thr  Glu Phe Glu His Tyr  Asp Arg Gln 
    1145                 1150                 1155             


Arg Gln  Glu Val Phe Arg Leu  Leu Gln Asn Ile Glu  Arg Leu Ile 
    1160                 1165                 1170             


Ile Glu  Ser His Pro Ala Ile  Ala Asp Ser Asn Ala  Gly Lys Pro 
    1175                 1180                 1185             


Gly Phe  Asn Asn Lys Glu Gly  Lys Pro Tyr Arg Asn  Ser Phe Ser 
    1190                 1195                 1200             


Ser Leu  Leu Ser Leu Cys Lys  Gln Tyr Leu Asn Glu  Gly Gly Glu 
    1205                 1210                 1215             


Pro Thr  Asp Val Ser Asn Leu  Leu Thr Glu Ile Arg  Asn Ala Tyr 
    1220                 1225                 1230             


Ser His  Asn Arg Tyr Val Lys  Ser Glu Ser Lys Asp  Leu Asp Ile 
    1235                 1240                 1245             


Arg Ser  Leu Ser Leu Pro Glu  Val Ala Asp His Ile  Leu Asn Trp 
    1250                 1255                 1260             


Leu Lys  Asn His Gln His Glu  
    1265                 1270 


<210>  2312
<211>  1330
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2312

Met Lys Asn Glu Gln Asn Arg Thr Asn Val His Phe Lys Leu Glu Asp 
1               5                   10                  15      


Val Asn Tyr Lys Ile Pro Tyr Asp Gln Gln Pro Glu Cys Lys Arg His 
            20                  25                  30          


Val Ile Gly Ala Tyr Ala Asn Leu Ala Arg His Asn Met Thr Val Thr 
        35                  40                  45              


Ile Asn Val Ile Met Gln Ala Ile Gly Met Lys Leu Phe Asn Glu Asn 
    50                  55                  60                  


Asp Ile Asp Asp Ala Phe Asn Lys Lys His Arg Thr Ile Ile Ala Lys 
65                  70                  75                  80  


Leu Asp Ser Ile Gln Lys Val Asn Leu Gln Lys Arg Leu Tyr Arg His 
                85                  90                  95      


Phe Pro Phe Phe Lys Arg Met Lys Leu Glu Asp Glu Thr Lys Lys Ser 
            100                 105                 110         


Val Gln Leu Asn Thr Leu Leu Glu Val Met Ala Asp Phe Thr Asn Cys 
        115                 120                 125             


Met Ala Met Leu Arg Asn Tyr Tyr Thr His Tyr His Pro Tyr Asn Thr 
    130                 135                 140                 


Pro Glu Glu Glu Lys Arg Gln Phe Glu Leu Arg Lys Ala Met Gly Lys 
145                 150                 155                 160 


Arg Leu Gln Tyr Leu Tyr Glu Asn Thr Cys Gln Leu Phe Lys Ser Asn 
                165                 170                 175     


Glu Ala Leu Asp His Glu Ser Asn Glu Val Leu Ser Ala Leu Arg Ile 
            180                 185                 190         


Pro Glu Asp Tyr Thr Gln Val Ile Lys Pro Gly Asp Asn Glu Tyr Lys 
        195                 200                 205             


Lys Thr Ser Glu Phe Tyr Phe Asn Pro Lys Ile Ser Glu Lys Lys Lys 
    210                 215                 220                 


Arg Gly Ile Lys Tyr Asp Pro Ser Thr Lys Val Phe Glu Lys Lys Ala 
225                 230                 235                 240 


Val Arg Phe Val Arg Asn Pro Asp Tyr Gln Ala Tyr Met Met Asp Asp 
                245                 250                 255     


Glu Lys Gly Met Ser Asp Thr Ala Ile Ile Tyr Phe Leu Cys Leu Phe 
            260                 265                 270         


Leu Glu Lys Lys Val Ser Phe Asp Leu Met Glu Glu Val Gly Phe Thr 
        275                 280                 285             


Lys Gln Ile Val Phe Lys Gly Glu His Ala Asp Gln Gln Leu Leu Tyr 
    290                 295                 300                 


Leu Lys Glu Ile Met Cys Met Asn Arg Ile Arg Met Thr Lys Thr Lys 
305                 310                 315                 320 


Leu Asp Ser Glu Met Thr Asp Thr Ala Leu Ala Leu Asp Met Ile Asn 
                325                 330                 335     


Glu Leu Arg Lys Cys Pro Lys Pro Leu Tyr Glu Val Phe Cys Lys Glu 
            340                 345                 350         


Ala Arg Asp Glu Phe Lys Asp Asp Ala Thr Val Ile Trp Glu Arg Glu 
        355                 360                 365             


His Gly His Glu Ala Ile Ala Thr Glu Glu Thr Gln Glu Val Asp Asn 
    370                 375                 380                 


Asp Gln Glu Leu Ser Glu Thr Thr Asp Lys Asn Thr Pro Arg Ser Thr 
385                 390                 395                 400 


Phe Val Arg Trp Glu Asp Arg Phe Pro Gln Met Ala Leu Lys Tyr Ile 
                405                 410                 415     


Asp Met Thr Arg Met Phe Asp Asp Ile Arg Phe Gln Leu Asn Leu Gly 
            420                 425                 430         


Lys Tyr Arg Phe Ala Phe Tyr Met His Asp Glu Lys Tyr Ser Val Asp 
        435                 440                 445             


Gly Gln Lys Arg Leu Arg Ile Leu Gln Lys Glu Ile His Gly Phe Gly 
    450                 455                 460                 


Arg Pro Ile Glu Val Asp Glu Lys Lys Ser Leu Lys Trp Ala Ser Leu 
465                 470                 475                 480 


Phe Asn Gln Arg Thr Val Gln Asp Gly Leu Thr Ile Lys Glu Pro Asp 
                485                 490                 495     


Thr Ala Gly Gln Asp Pro Tyr Ile Thr Glu Gln Arg Ala Gln Tyr Ala 
            500                 505                 510         


Ile Asp Glu Lys Ala His Ser Ile Gly Leu Arg Trp Glu Gly Trp Asp 
        515                 520                 525             


Asn Pro Asn Arg Lys Thr Ile Val Asp Glu Asn Gly Lys Glu Lys Lys 
    530                 535                 540                 


Glu Pro His Tyr Gly Asp Leu Asp Lys Glu Lys Met Phe Ile Pro Tyr 
545                 550                 555                 560 


Leu Pro Ser Thr Pro Val Lys Glu Glu Arg Gln Thr Asn Gln Ala Glu 
                565                 570                 575     


Pro Leu Leu Ala Pro Gln Cys Thr Leu Ser Leu Tyr Glu Leu Pro Gly 
            580                 585                 590         


Leu Leu Phe Tyr Gln Tyr Leu Met Thr Lys Tyr Lys Ser Ser Lys Tyr 
        595                 600                 605             


Asp Ala Glu Ser Val Val Lys Asn Thr Phe Ser Asn Leu Asn Leu Phe 
    610                 615                 620                 


Phe Asn Asp Val Ala Lys Gly Val Leu Cys Pro Val Glu Gly Lys Asp 
625                 630                 635                 640 


Glu Asn Thr Arg Lys Gln Glu Met Glu Lys Leu Leu Lys Glu Lys Tyr 
                645                 650                 655     


Lys Leu Gln Leu Ser Ser Val Pro Glu Lys Leu Lys Met Tyr Leu Ile 
            660                 665                 670         


Gly Ser Asn Val Asp Asn Ala Gln Arg Met Glu Ala Ser Ala Leu Arg 
        675                 680                 685             


Arg Leu Asn Glu Arg Arg Glu Arg Lys Asn Lys Ala Leu Glu Ser Phe 
    690                 695                 700                 


Arg Asn Lys Lys Lys Val Ile Gly Ser Lys Asp Asn Lys Phe Asp Lys 
705                 710                 715                 720 


Met Arg Ser Thr Ile Lys Thr Gly Ser Leu Gly Gln Leu Leu Ala Arg 
                725                 730                 735     


Asp Ile Met Glu Trp Leu Thr Asp Glu Thr Lys Gly Lys Met Asn Leu 
            740                 745                 750         


Thr Gly Gln Asn Tyr Ile Ala Met Gln Thr Ala Leu Ala Leu Leu Gly 
        755                 760                 765             


Gln Arg Phe Asp Asp Asn Ser Glu Glu Ile Thr Trp Asn Lys Leu Arg 
    770                 775                 780                 


Glu Ile Phe Ile Ser Ala Asn Ile Leu Pro Gln Asn Ala Asp Asp Tyr 
785                 790                 795                 800 


Asp Ala Asp Leu His His Pro Phe Leu Gln Lys Val Leu Asp Glu Ala 
                805                 810                 815     


Pro Thr Ser Val Glu Glu Phe Tyr Glu Ile Tyr Leu Glu Lys Glu Ile 
            820                 825                 830         


Asn His Ile Asp Asp Ile Thr Thr Leu Phe Lys Lys His Lys Ala Lys 
        835                 840                 845             


Gly Ile Gly Leu Tyr Ile Pro Phe Leu His Val Asn Arg Ile Arg Trp 
    850                 855                 860                 


Gln Asn Thr Asp Ala Glu Gly Met Lys Lys Leu Ala Ser Arg Tyr Thr 
865                 870                 875                 880 


Glu Arg Pro Leu Gln Leu Pro Asn Gly Met Phe Ser Thr Pro Ile Leu 
                885                 890                 895     


His Ile Leu Met Glu Ile Lys Asn Pro Lys Leu His Lys Ala Leu Glu 
            900                 905                 910         


Lys Ile Gln Asn Asp Glu Lys Gly Val Gln Leu Ser Asn Asn Ile Gly 
        915                 920                 925             


Tyr Leu Met Lys Leu Tyr Phe Lys Phe Val Glu Arg Asp His Ser Gln 
    930                 935                 940                 


Pro Phe Tyr Asn Thr Thr Ala Ile Asp Gly Gln Pro Ser Pro Tyr Arg 
945                 950                 955                 960 


His Val Tyr Arg Ile Phe Lys Lys Leu Tyr Gly Glu Lys Ile Pro His 
                965                 970                 975     


Thr Asn Arg Thr Thr Ser Pro Ala Tyr Ser Ile Glu Glu Leu Arg Gly 
            980                 985                 990         


Leu Arg Lys Lys Ser Ile Glu Asp  Ile Asn Ala Tyr Val  Asp Lys Glu 
        995                 1000                 1005             


Ile Gln  Ala Trp Lys Glu Lys  Arg Leu Thr Lys Phe  Glu Lys Lys 
    1010                 1015                 1020             


Leu Thr  Asp Lys Leu Lys Lys  Glu Asn Asp Arg Arg  Tyr Lys Asn 
    1025                 1030                 1035             


Tyr Glu  Lys Gln Leu Asn Ile  Lys Glu Glu Val Arg  Ala Ala Val 
    1040                 1045                 1050             


Glu Lys  Glu Glu Leu Ala Met  Leu Pro Glu Leu Glu  Ala Met Arg 
    1055                 1060                 1065             


His Glu  Met Thr Ser Lys Leu  Glu Lys Lys Leu Lys  Lys Val Tyr 
    1070                 1075                 1080             


Asp Asn  Glu Arg Ala Ile Arg  Arg Phe Lys Ser Gln  Asp Thr Leu 
    1085                 1090                 1095             


Leu Leu  Ile Met Ala Arg Glu  Ile Leu Lys Ala Lys  Ser Lys Asp 
    1100                 1105                 1110             


Gln Asp  Phe Thr Lys Gly Phe  Asn Leu Lys Tyr Val  Met Thr Asp 
    1115                 1120                 1125             


Ser Leu  Leu Asp Lys Arg Ile  Asp Phe Ser Trp Asp  Val Leu Ile 
    1130                 1135                 1140             


Gln Asp  Lys Lys Thr Gly Ser  Val Arg Lys Ser Ile  Lys Gln Lys 
    1145                 1150                 1155             


Asp Met  Lys Met Lys Asn Tyr  Gly Gln Phe Tyr Lys  Phe Ala Ser 
    1160                 1165                 1170             


Asp His  Gln Arg Leu Glu Ser  Leu Leu Ser Arg Leu  Pro Gln Ser 
    1175                 1180                 1185             


Val Phe  Gln Arg Ala Glu Ile  Glu Asn Glu Phe Ser  Tyr Tyr Asp 
    1190                 1195                 1200             


Thr Asn  Arg Ser Glu Val Phe  Arg Gln Val Tyr Ile  Ile Glu Ser 
    1205                 1210                 1215             


Glu Ala  Tyr Lys Leu Lys Pro  Gly Leu Glu Asp Asp  Asn Asn Ala 
    1220                 1225                 1230             


Asn His  Glu Trp Phe Asn Tyr  Ile Asp Lys Lys Thr  Ala Lys Pro 
    1235                 1240                 1245             


His Pro  Ile Arg Asn Ser Phe  Ile Gln Leu Leu Glu  Ile Leu Ala 
    1250                 1255                 1260             


Ala Gly  Lys Asp Gly Ile Leu  Asp Asp Lys Glu Lys  Ile Ala Ile 
    1265                 1270                 1275             


Gln Lys  Thr Arg Asn Ala Phe  Gly His Asn Thr Tyr  Asp Val Asp 
    1280                 1285                 1290             


Leu Pro  Ala Val Phe Glu Gly  Lys Glu Glu Lys Met  Lys Ile Pro 
    1295                 1300                 1305             


Glu Val  Ala Asn Gly Ile Lys  Asp Lys Ile Glu Glu  Gln Thr Gly 
    1310                 1315                 1320             


Glu Met  Thr Lys Lys Ile Lys  
    1325                 1330 


<210>  2313
<211>  1113
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2313

Met Glu Ser Leu Ile Gln Gln Glu Glu Asn Lys Ala Arg Asn Leu Ile 
1               5                   10                  15      


Asp Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg His Asn 
            20                  25                  30          


Ile Phe Ser Ile Asn Asn His Leu Ala Ser Tyr Phe Gly Thr Ser Gly 
        35                  40                  45              


Leu Ser Asn Glu Glu Gln Ile Pro Asp Ser Phe Leu Leu Ser Ala Asp 
    50                  55                  60                  


Lys Arg Arg Asn Gln Glu Thr Lys Glu Leu Ile Lys Glu Asn Leu Leu 
65                  70                  75                  80  


Phe Glu Arg Thr Leu Arg Phe Met Pro Ile Phe Arg Ile Phe Asp Thr 
                85                  90                  95      


Glu Arg Leu Pro Lys Glu Val Arg Leu Asn Thr Glu Asn Met Glu Lys 
            100                 105                 110         


Asp Phe Asp Glu Met Arg Lys Cys Leu Lys Gln Val Phe Ser Glu Leu 
        115                 120                 125             


Asn Ile Phe Arg Asn Asp Tyr Thr His Tyr Phe Ser Thr Asn Thr Glu 
    130                 135                 140                 


Thr Thr Arg Lys Leu Gln Val Thr Pro Glu Leu Glu Glu Phe Leu Ser 
145                 150                 155                 160 


Arg Ser Phe Lys Leu Ala Ile Ala Phe Thr Lys Gln Arg Met Arg Asp 
                165                 170                 175     


Val Leu Lys Glu Glu Asp Tyr Ser Leu Val Glu Lys Lys Val Met Val 
            180                 185                 190         


Leu Pro Glu Glu Arg Val Ile Thr Thr Glu Gly Ile Val Phe Leu Ala 
        195                 200                 205             


Cys Met Phe Leu Glu Arg Glu Tyr Ala Phe Gln Phe Ile Gly Lys Val 
    210                 215                 220                 


Val Gly Leu Lys Gly Thr His Arg Asn Glu Phe Ile Ala Thr Arg Glu 
225                 230                 235                 240 


Val Leu Met Ala Tyr Cys Val Lys Leu Pro His Asp Lys Phe Ile Ser 
                245                 250                 255     


Glu Asp Ser Lys Gln Ala Leu Ile Leu Asp Ile Ala Asn Glu Leu Asn 
            260                 265                 270         


Lys Cys Pro Leu Thr Leu Tyr Asp Val Ile Thr Glu Asp Gly Arg Lys 
        275                 280                 285             


Gln Phe Arg Pro Glu Leu Thr Asp Asp Ala Lys Lys Ser Val Ile Glu 
    290                 295                 300                 


Asn Cys Ile Asn Glu Asp Leu Glu Val Asp Tyr Asp Glu Tyr Ile Gln 
305                 310                 315                 320 


Ile Leu Thr Lys Lys Val Arg Tyr Lys Asn Arg Phe Pro Tyr Phe Ala 
                325                 330                 335     


Phe Gln Tyr Ile Glu Glu Thr Lys Leu Leu Asp Asn Phe Arg Phe Ser 
            340                 345                 350         


Ile Asp Leu Gly Gln Phe Val Leu Ala Glu Tyr Glu Lys Arg Met Ala 
        355                 360                 365             


Gly Glu Pro Thr Ser Arg Ile Val Val Glu Asn Val Lys Ala Phe Lys 
    370                 375                 380                 


Tyr Leu Lys Glu Val Thr Asp Glu Asp Val Val Leu Gly Leu Met Lys 
385                 390                 395                 400 


Ser Asn Pro Pro Ser Asn Arg Phe Leu Gln Phe Ser Pro His Tyr Asn 
                405                 410                 415     


Ser Asp Asn Asn Lys Ile Gly Ile Ser Ser Lys Pro Gln Thr Ser Val 
            420                 425                 430         


Val Lys Ser Lys Gly Lys Ile Asp Ser Lys Ile Glu Tyr Lys Ile Lys 
        435                 440                 445             


Gln Pro Leu Pro Arg Ala Phe Val Ser Ile His Glu Leu Pro Lys Ile 
    450                 455                 460                 


Ile Leu Leu Asp Tyr Leu Ser Lys Gly Ser Val Val Lys Ile Ile Asn 
465                 470                 475                 480 


Ser Phe Ile Arg Thr Asn Lys Ser Ile Ile Leu Asp Val Asp Lys Ile 
                485                 490                 495     


Lys Glu Ile Lys Glu Lys Leu Pro Asn Asn Glu Val Trp Phe Pro Phe 
            500                 505                 510         


Arg Arg Met Thr Asp Ser Lys Lys His Ser Ala Tyr Ser Glu Lys Gln 
        515                 520                 525             


Lys Ala Glu Ile Leu Arg Arg Lys Lys Leu Leu Asn Glu Ile Leu Ser 
    530                 535                 540                 


Ser Tyr Ser Leu Asn Ile Lys Gln Ile Pro Ser Arg Ile Ile Asp Tyr 
545                 550                 555                 560 


Trp Leu Asn Ile Ile Asp Val Arg Lys Glu Arg Ser Phe Ser Asp Arg 
                565                 570                 575     


Ile Lys Leu Met Lys Arg Asp Cys Ala Asp Arg Tyr Lys Ala Val Lys 
            580                 585                 590         


Arg Asn Glu Lys Asp Lys Thr Val Ala Ile Pro Lys Ile Gly Glu Met 
        595                 600                 605             


Ala Thr Phe Leu Ala Lys Asp Ile Val Ala Met Ile Val Asp Glu Asp 
    610                 615                 620                 


Lys Lys Ser Lys Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys 
625                 630                 635                 640 


Leu Ala Leu Tyr Ala Asn Ile Glu Lys Lys Asn Leu Phe Ile His Leu 
                645                 650                 655     


Val Thr Asn Glu Leu Lys Leu Asn Glu Lys Gly Gly His Pro Phe Leu 
            660                 665                 670         


Lys Arg Ile Asn Leu Asn Ser Ile Thr Arg Thr Lys Glu Leu Tyr Glu 
        675                 680                 685             


Ile Tyr Leu Ser Glu Lys Ala Tyr Lys Leu Asn Ser Lys Glu Asn Asp 
    690                 695                 700                 


Glu Ser Trp Met Ser Met Thr Phe Tyr His Leu Glu Trp Asn Glu Lys 
705                 710                 715                 720 


Ala Lys Lys Lys Met Thr Lys Val Val Tyr Pro Val Asn Asp Glu Gln 
                725                 730                 735     


Ile Pro Tyr Thr Ile Lys Gln Trp Asn Lys Pro Gln Gln Pro Leu Phe 
            740                 745                 750         


Asp Arg Phe Thr Asn Glu Gln Gly Lys Ser Ser Asp Trp Val Arg Leu 
        755                 760                 765             


Lys Pro Leu Asp Leu Pro Thr Asn Leu Phe Asp Glu Glu Ile Cys Val 
    770                 775                 780                 


Gln Leu Arg Ser Arg Leu Gln Glu Ala Lys Ile Pro Phe Asp Asn Ile 
785                 790                 795                 800 


Ser Asn Tyr Ser Glu Leu Leu Lys Leu Trp Trp Lys Ser Arg Asp Asp 
                805                 810                 815     


Ser Thr Gln Pro Phe Tyr Leu Leu Glu Arg Gln Tyr Asn Ile Tyr Asp 
            820                 825                 830         


Glu Ser Val Arg Phe Thr Leu Asn Ser Lys Asn Lys Phe Lys Asp Tyr 
        835                 840                 845             


Tyr Gln Ala Ala Leu Lys Lys Val Phe Asn Gln Lys Lys Ala Glu Arg 
    850                 855                 860                 


Glu Ala Lys Arg Arg Phe Asn Lys Arg Leu Pro Asp Ile Gln Phe Lys 
865                 870                 875                 880 


Asp Val Glu Arg Val Phe Lys His Ala Ile Ala Glu Thr Glu Lys Gln 
                885                 890                 895     


Ile Arg Ile Ile Gln Glu Glu Asp Arg Ile Met Leu Leu Met Leu Glu 
            900                 905                 910         


Lys Leu Met Asp Asp Gln Gln Leu Lys Leu Gly Lys Ala Glu Thr Leu 
        915                 920                 925             


Leu Ser Ser Thr Val Pro Val Lys Gln Lys Ile Gly Asp Lys Thr Asn 
    930                 935                 940                 


Ser Ser Arg Val Ile Val Ala Gln Arg Lys Gln Lys His Tyr Thr Val 
945                 950                 955                 960 


Leu Arg Lys Tyr Gln Tyr Asp Arg Arg Leu Pro Glu Leu Phe Lys Tyr 
                965                 970                 975     


Thr Thr Glu Lys Glu Glu Leu Lys Leu Glu Trp Leu Glu Asp Glu Leu 
            980                 985                 990         


Lys Ala Tyr Asn Lys Gly Lys Leu  Lys Val Phe Asp Leu  Val Phe Ser 
        995                 1000                 1005             


Leu Glu  Lys Arg Ile Ile Glu  Val Ala Lys Gln Asp  Ile Ile Ala 
    1010                 1015                 1020             


Leu Leu  Asp Lys Ser Gly Ser  Asn Asp Ser Lys Phe  Asn Val Asp 
    1025                 1030                 1035             


His Lys  Pro Tyr Ile Lys Trp  Leu Glu Asn Met Glu  Leu Ile Asn 
    1040                 1045                 1050             


Ser Lys  Glu Ala Gly Phe Met  Lys Lys Ile Arg Asn  Ser Phe Ser 
    1055                 1060                 1065             


His Asn  Gln Phe Pro Glu Cys  Gln Thr Val Glu Leu  Met Ile Ser 
    1070                 1075                 1080             


Leu Lys  Ser Asp Ile Pro Ile  Ala Thr Gln Ile Val  Asn Glu Tyr 
    1085                 1090                 1095             


Glu Arg  Leu Ile Leu Arg Ile  Ser Ser Gln Ile Glu  Lys Met Lys 
    1100                 1105                 1110             


<210>  2314
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2314

Met Asn Asn Thr Met Asp Ala Glu Gly Lys Asn Glu Arg Thr Leu Gln 
1               5                   10                  15      


Asp Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Val Ala Asp Lys Leu Ser Ile Ala Leu 
        35                  40                  45              


Leu Lys Asn Glu Glu Asp Ile Asn Asn Ser Phe Leu Cys Asn Ser Asn 
    50                  55                  60                  


Gln Lys Leu Asn Trp Ser Lys Ala Tyr Ala Met Thr Met Arg Phe Met 
65                  70                  75                  80  


Pro Leu Leu Lys Val Phe Asp Thr Glu Arg Leu Pro Glu His Arg Thr 
                85                  90                  95      


Ser Gln Lys Asp Lys Glu Lys Gly Lys Glu Phe Gly Ile Met Cys Asp 
            100                 105                 110         


Ser Leu Arg Ile Val Phe Arg Glu Leu Asn Gln Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Thr Ser Thr Glu Asp Asn Phe Thr Arg Lys Ile Glu Ile 
    130                 135                 140                 


Ser Pro Glu Leu Ala Glu Phe Leu Thr Cys Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Glu Tyr Thr Lys Gln Arg Phe Ala Asp Thr Tyr Gln Asn Glu Asp Phe 
                165                 170                 175     


Ile Leu Ala Glu Arg Met Gln Met Val Lys Ser Asn Ile Ile Thr Thr 
            180                 185                 190         


Glu Gly Ile Val Phe Leu Thr Ser Leu Phe Leu Glu Arg Glu His Ala 
        195                 200                 205             


Phe Leu Phe Ile Gly Lys Val Lys Gly Leu Lys Gly Thr Gln Tyr Lys 
    210                 215                 220                 


Gln Phe Lys Ala Thr Arg Glu Val Phe Met Ser Tyr Cys Val Asn Leu 
225                 230                 235                 240 


Pro Gln Asp Lys Leu Ile Ser Asp Asp Tyr Thr Gln Ser Leu Thr Met 
                245                 250                 255     


Asp Ile Ile Asn Glu Leu Thr Lys Cys Pro Glu Thr Leu Tyr Asn Val 
            260                 265                 270         


Leu Asp Glu Ser Ala Arg Lys Gln Phe Ile Pro Gln Leu Gly Glu Val 
        275                 280                 285             


Glu Thr Asp Asn Val Arg Gln Asn Ser Ile Asn Glu Ala Glu Leu Thr 
    290                 295                 300                 


Asp Glu Asn Asp Tyr Ala Gln Tyr Met Glu Asp Ile Thr Lys Arg Val 
305                 310                 315                 320 


Arg His Ser Asn Arg Phe Pro Tyr Phe Ala Leu Arg Phe Ile Asp Glu 
                325                 330                 335     


Leu Asp Leu Leu Gly Lys Phe Lys Phe Gln Leu Asp Leu Gly Lys Leu 
            340                 345                 350         


Lys Leu Asn Thr Tyr Pro Lys Pro Tyr Met Gly Glu Asp Val Asp Arg 
        355                 360                 365             


Ala Ile Thr Glu Asn Val Ser Ala Phe Gly Lys Leu Ser Asp His Gln 
    370                 375                 380                 


Val Lys Glu Glu Val Gln Ala Lys Val Val Lys Asp Tyr Ser Ser Val 
385                 390                 395                 400 


Gln Phe Asp Gln Phe Ala Pro His Tyr Asn Met Glu Cys Asn Lys Ile 
                405                 410                 415     


Gly Ile Ser Arg Lys Ser Glu Thr Ala Ile Val Ile Lys Pro Ser Glu 
            420                 425                 430         


Thr Gly Val Lys Ser Ala Tyr Lys Leu Lys Gln Pro Ile Pro Glu Ala 
        435                 440                 445             


Phe Leu Ser Ile Lys Glu Leu Ser Lys Ile Val Leu Leu Glu Tyr Leu 
    450                 455                 460                 


Ser Pro Gly Glu Ser Gln Arg Phe Ile Thr Asp Phe Ile Cys Thr Asn 
465                 470                 475                 480 


Ser Asp Lys Leu Met Asn Leu Asp Phe Ile Lys Glu Val Lys Gly Lys 
                485                 490                 495     


Leu Pro Val Phe Asp Lys Pro Phe Tyr Lys Lys Val Thr Ile Lys Arg 
            500                 505                 510         


Lys Ser Tyr Thr Lys His Glu Leu Thr Asp Leu Glu Ala Arg Lys Asn 
        515                 520                 525             


Leu Leu Asp Gln Val Leu Val Thr Tyr Gly Leu Asn Thr Lys Gln Ile 
    530                 535                 540                 


Pro Thr Arg Ile Thr Glu Tyr Trp Leu Asn Ile Arg Asp Val Arg Asn 
545                 550                 555                 560 


Gln Tyr Ile Ile Ser Glu Arg Ile Lys Ser Met Arg Lys Asp Cys Thr 
                565                 570                 575     


Thr Arg Leu Lys Ser Leu Lys Lys Leu Asp Glu Thr Gly Lys Gly Lys 
            580                 585                 590         


Val Pro Lys Ile Gly Glu Met Ala Ser Phe Leu Ala Arg Asp Ile Val 
        595                 600                 605             


Ser Leu Val Ile Asp Pro Val Lys Lys Lys Lys Ile Thr Ser Phe Tyr 
    610                 615                 620                 


Tyr Asp Lys Leu Gln Ala Ser Leu Ala Leu Phe Ala Asp Pro Asp Lys 
625                 630                 635                 640 


Lys Lys Glu Phe Met His Leu Val Lys Asp Glu Leu Asn Leu Leu Ser 
                645                 650                 655     


Val Gly Gly His Pro Phe Leu Ile Asn Ile Asp Phe Thr Thr Ile His 
            660                 665                 670         


Tyr Thr Arg Asp Leu Tyr Lys Lys Tyr Leu Glu Glu Lys Gly Cys Lys 
        675                 680                 685             


Ile Thr Asn Asp Arg Lys Asp Ile Ser Trp Ile Phe Asn Thr Phe Tyr 
    690                 695                 700                 


Lys Lys Glu Pro Gly Lys Asn Ser Ser Leu Pro Val Thr Lys Val Lys 
705                 710                 715                 720 


Leu Pro Leu Asp Lys Asn Gly Asn Pro Asp Ser Lys Arg Leu Pro His 
                725                 730                 735     


Ser Leu Tyr Ser Leu Gly Asn Arg Lys Thr Asp Asn Ser Ile Glu Glu 
            740                 745                 750         


Ile Glu Lys Trp Leu Ser Asn Val Lys His Gly Lys Met Lys Thr Asp 
        755                 760                 765             


Cys Thr Lys Pro Val Asp Leu Pro Thr Asn Leu Phe Asp Ser Arg Leu 
    770                 775                 780                 


Ile Glu Leu Leu Gln Lys Glu Thr Gly Asp Thr Ser Leu Ala Pro Lys 
785                 790                 795                 800 


Leu Asn Gly Leu Phe Val Thr Trp Trp Lys Lys Arg Gly Asp Ser Thr 
                805                 810                 815     


Gln Ser Phe Tyr Asn Asp Lys Arg Asn Tyr Val Ile Tyr Asp Gln Glu 
            820                 825                 830         


Val Cys Phe Leu Pro Asn Thr Lys Lys Leu Tyr Gln Asp Tyr Tyr Gln 
        835                 840                 845             


Ser Ala Leu Asp Arg Ala Phe Arg Leu Lys Arg Glu Glu Arg Arg Gln 
    850                 855                 860                 


Glu Arg Leu Leu Asn Ile Arg Leu Pro Asp Ile Gln Leu Lys Asp Met 
865                 870                 875                 880 


Lys Lys Ile Phe Asn Ile Thr Leu Ser Glu Thr Glu Lys Glu Ile Arg 
                885                 890                 895     


Ile Leu Gln Glu Glu Asp Arg Leu Leu Leu Leu Ile Leu Glu Lys Leu 
            900                 905                 910         


Met Glu Lys Glu Ile Ala Gly Thr Leu Asn Leu Lys Asn Val Asn Asp 
        915                 920                 925             


Leu Leu Asn Glu Gln Val Asp Ile Cys Gln Gln Val Lys Thr Tyr Leu 
    930                 935                 940                 


Ser Phe Lys Glu Asn Gly Glu Leu Ala Ser Lys Asp Glu Arg Met Gln 
945                 950                 955                 960 


Ile Thr Lys Asn Ile Ile Ser Tyr Gly Ser Arg Lys Asn Tyr Gly Leu 
                965                 970                 975     


Leu Arg Arg Tyr Val His Asp Arg Arg Met Pro Glu Leu Phe Glu Tyr 
            980                 985                 990         


Tyr Pro Thr Asp Asp Ile Pro Phe  Glu Ala Ile Lys Gln  Glu Leu Glu 
        995                 1000                 1005             


Ala Tyr  Asn Lys Ala Lys Gln  Ile Val Phe Asp Lys  Val Phe Glu 
    1010                 1015                 1020             


Leu Glu  Arg Ala Leu Thr Glu  Arg Phe Lys Asp Glu  Val Met Ala 
    1025                 1030                 1035             


His Phe  Val Asn Arg Asp Gly  Gly Ser Arg Leu Lys  Gly Asn Ile 
    1040                 1045                 1050             


Gln His  Ser Pro Tyr Leu Asn  Leu Leu Glu Ser Lys  Gly Ile Ile 
    1055                 1060                 1065             


Ser Lys  Asp Ala His Arg Phe  Leu Lys Ala Val Arg  Asn Ala Phe 
    1070                 1075                 1080             


Ser His  Asn Gln Tyr Pro His  Lys Lys Thr Met Glu  Ile Phe Val 
    1085                 1090                 1095             


Lys Glu  Trp Asn Thr Ser Asn  Phe Ala Asn Gln Ile  Val Asp Ile 
    1100                 1105                 1110             


Tyr Lys  Gln Lys Ile Asp Glu  Val Ile Asp Asn Ile  Lys Lys 
    1115                 1120                 1125         


<210>  2315
<211>  1113
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2315

Met Glu Ser Leu Ile Gln His Glu Glu Asn Lys Ala Arg Asn Leu Ile 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg His Asn 
            20                  25                  30          


Ile Phe Ser Ile Asp Asn His Leu Ala Ser Cys Phe Glu Thr Ser Lys 
        35                  40                  45              


Leu Ser Asn Glu Lys His Ile Ser Asp Ser Phe Leu Leu Ser Ala Asp 
    50                  55                  60                  


Lys Arg Lys Asn Lys Thr Asn Lys Glu Pro Ile Asn Glu Asn Leu Leu 
65                  70                  75                  80  


Phe Glu Arg Thr Leu Arg Phe Met Pro Ile Leu Arg Val Phe Asp Thr 
                85                  90                  95      


Glu Arg Leu Pro Lys Glu Val Arg Leu Asn Thr Glu Asn Met Gly Lys 
            100                 105                 110         


Asp Phe Asp Glu Met Arg Asn Cys Leu Lys Gln Ala Phe Ser Glu Leu 
        115                 120                 125             


Asn Lys Phe Arg Asn Asp Tyr Thr His Tyr Phe Ser Thr Asn Thr Glu 
    130                 135                 140                 


Thr Asn Arg Lys Leu Gln Val Thr Ser Glu Leu Glu Glu Phe Leu Thr 
145                 150                 155                 160 


Arg Ser Phe Lys Leu Ala Ile Ala Phe Thr Lys Gln Arg Met Arg Asp 
                165                 170                 175     


Val Leu Lys Glu Glu Asp Tyr Ser Leu Val Glu Lys Lys Val Met Val 
            180                 185                 190         


Leu Pro Glu Glu Arg Phe Ile Thr Thr Glu Gly Ile Val Phe Leu Ala 
        195                 200                 205             


Cys Met Phe Leu Glu Arg Glu Tyr Ala Phe Gln Phe Ile Gly Lys Val 
    210                 215                 220                 


Val Gly Leu Lys Gly Thr His Arg Asn Glu Phe Ile Ala Thr Arg Glu 
225                 230                 235                 240 


Val Leu Met Ala Tyr Cys Val Lys Leu Pro His Asp Lys Phe Ile Ser 
                245                 250                 255     


Glu Asp Ser Arg Gln Ala Leu Ile Leu Asp Ile Ala Asn Glu Leu Asn 
            260                 265                 270         


Lys Cys Pro Leu Thr Leu Tyr Asp Val Ile Thr Glu Asp Gly Arg Lys 
        275                 280                 285             


Gln Phe Arg Pro Glu Leu Thr Asp Asp Ser Lys Arg Ser Val Ile Glu 
    290                 295                 300                 


Asn Cys Ile Asn Glu Asp Leu Glu Val Asp Tyr Asp Glu Tyr Ile Gln 
305                 310                 315                 320 


Ile Leu Thr Lys Lys Val Arg Tyr Lys Asn Arg Phe Pro Tyr Phe Ala 
                325                 330                 335     


Phe Gln Tyr Ile Glu Glu Thr Lys Leu Leu Asp Asn Phe Arg Phe Ser 
            340                 345                 350         


Ile Asp Leu Gly Gln Phe Val Leu Ala Glu Tyr Glu Lys Arg Leu Ala 
        355                 360                 365             


Gly Glu Pro Thr Ser Arg Ile Val Val Glu Asn Val Lys Thr Phe Lys 
    370                 375                 380                 


Tyr Leu Arg Asn Val Ile Asn Glu Asp Val Val Phe Glu Leu Lys Glu 
385                 390                 395                 400 


Ser Asn Leu Gln Ser Asn Arg Phe Leu Gln Phe Ser Pro His Tyr Ser 
                405                 410                 415     


Ser Asn Asn Asn Lys Ile Gly Ile Ser Ser Glu Ser Gln Pro Ser Val 
            420                 425                 430         


Val Lys Ser Lys Gly Lys Ile Glu Ser Lys Ile Asp Tyr Lys Ile Lys 
        435                 440                 445             


Gln Pro Leu Pro Glu Ala Phe Val Ser Ile His Glu Leu Pro Lys Ile 
    450                 455                 460                 


Ile Leu Leu Asp Tyr Leu Ser Lys Gly Ser Val Val Lys Ile Ile Asn 
465                 470                 475                 480 


Ser Phe Ile Arg Thr Asn Lys Ser Ile Ile Leu Asp Ile Asp Lys Ile 
                485                 490                 495     


Lys Glu Ile Lys Glu Lys Leu Pro Asn Asn Glu Val Trp Val Pro Phe 
            500                 505                 510         


Arg Arg Leu Thr Asp Ser Lys Lys His Ser Ala Tyr Ser Glu Glu Gln 
        515                 520                 525             


Lys Asp Glu Ile Leu Arg Arg Lys Lys Leu Leu Asn Glu Ile Leu Ser 
    530                 535                 540                 


Ser Tyr Ser Leu Asn Ile Lys Gln Ile Pro Ser Arg Ile Ile Asp Tyr 
545                 550                 555                 560 


Trp Leu Asn Ile Ile Asp Val Arg Lys Glu Arg Ser Phe Ser Asp Arg 
                565                 570                 575     


Ile Lys Leu Met Lys Arg Asp Cys Ala Glu Arg Tyr Lys Ala Ile Lys 
            580                 585                 590         


Arg Asn Glu Lys Asp Lys Thr Val Ser Ile Pro Lys Ile Gly Glu Met 
        595                 600                 605             


Ala Thr Phe Leu Ala Lys Asp Ile Ile Ala Met Ile Ala Asp Glu Asp 
    610                 615                 620                 


Lys Lys Ser Lys Ile Thr Ser Phe Tyr Tyr Asp Lys Leu Gln Glu Cys 
625                 630                 635                 640 


Leu Ala Leu Tyr Ala Asn Ile Glu Lys Lys Lys Leu Phe Ile His Ile 
                645                 650                 655     


Val Thr Asn Glu Leu Arg Leu Asn Glu Lys Gly Gly His Pro Phe Leu 
            660                 665                 670         


Lys Gly Ile Asn Leu Asn Ser Ile Thr Arg Thr Lys Glu Leu Tyr Glu 
        675                 680                 685             


Ile Tyr Leu Ser Glu Lys Ala Tyr Lys Leu Asn Ser Arg Glu Asn Asp 
    690                 695                 700                 


Glu Ser Trp Met Ser Met Thr Phe Tyr His Gln Glu Trp Asn Glu Lys 
705                 710                 715                 720 


Ala Met Lys Lys Met Thr Lys Val Val Tyr Pro Val Asn Asp Glu Gln 
                725                 730                 735     


Ile Pro Tyr Thr Ile Lys Gln Trp Asn Lys Pro Gln Gln Leu Leu Phe 
            740                 745                 750         


Asp Arg Phe Thr Asn Glu Gln Gly Lys Ser Ser Asp Trp Val Arg Leu 
        755                 760                 765             


Lys Pro Leu Asp Leu Pro Thr Asn Leu Phe Asp Glu Glu Ile Cys Val 
    770                 775                 780                 


Gln Leu Arg Ser Arg Leu Gln Glu Ala Lys Ile Pro Phe Asp Asn Lys 
785                 790                 795                 800 


Ser Asn Tyr Ser Glu Leu Leu Lys Leu Trp Trp Glu Ser Arg Asp Asp 
                805                 810                 815     


Ser Thr Gln Pro Tyr Tyr Gln Leu Glu Arg Gln Tyr Asn Ile Tyr Asp 
            820                 825                 830         


Glu Ser Val Arg Phe Thr Leu Asn Ser Lys Asn Lys Phe Lys Asp Tyr 
        835                 840                 845             


Tyr Gln Ala Thr Leu Lys Lys Val Phe Asn Gln Lys Lys Ala Glu Arg 
    850                 855                 860                 


Glu Ala Lys Arg Arg Ile Asn Lys Arg Leu Pro Asp Ile Gln Phe Lys 
865                 870                 875                 880 


Asp Leu Glu Arg Val Phe Lys His Ala Ile Ala Glu Thr Glu Lys Gln 
                885                 890                 895     


Ile Arg Ile Ile Gln Glu Glu Asp Arg Ile Met Leu Leu Met Leu Glu 
            900                 905                 910         


Lys Leu Met Asp Asp Gln Gln Leu Lys Leu Gly Lys Ala Glu Thr Leu 
        915                 920                 925             


Leu Ser Ser Thr Val Pro Ile Lys Gln Lys Ile Gly Asp Lys Thr Asn 
    930                 935                 940                 


Ser Ser Arg Val Ile Val Ala Gln Arg Lys Gln Lys His Tyr Thr Val 
945                 950                 955                 960 


Leu Arg Lys Tyr Gln Tyr Asp Arg Arg Leu Pro Glu Leu Phe Glu Tyr 
                965                 970                 975     


Thr Thr Glu Lys Glu Glu Leu Lys Leu Glu Trp Leu Glu Asp Glu Leu 
            980                 985                 990         


Lys Ala Tyr Asn Lys Gly Lys Leu  Lys Val Phe Asp Leu  Val Phe Ser 
        995                 1000                 1005             


Leu Glu  Lys Arg Ile Ile Glu  Val Ala Lys Gln Asp  Ile Ile Ala 
    1010                 1015                 1020             


Leu Phe  Asp Lys Pro Gly Ser  Asn Asp Ser Lys Phe  Asn Val Asp 
    1025                 1030                 1035             


His Lys  Pro Tyr Ile Lys Trp  Leu Glu Lys Lys Glu  Leu Ile Asn 
    1040                 1045                 1050             


Ser Val  Glu Ala Gly Phe Met  Lys Lys Ile Arg Asn  Ser Phe Ser 
    1055                 1060                 1065             


His Asn  Gln Phe Pro Glu Cys  Gln Thr Val Glu Leu  Met Ile Ser 
    1070                 1075                 1080             


Leu Met  Ser Asp Ile Pro Ile  Ala Thr Gln Ile Val  Asn Glu Tyr 
    1085                 1090                 1095             


Glu Arg  Leu Ile Leu Arg Ile  Ser Ser Gln Ile Glu  Glu Met Lys 
    1100                 1105                 1110             


<210>  2316
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2316

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2317
<211>  974
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2317

Met Ser Ile Thr Pro Lys Lys Met Tyr Asn Ile Phe Asp Asn Asn Ile 
1               5                   10                  15      


Gln Leu Val Ile Lys Asp Tyr Gln His Asn Lys Asp Ile Asn Pro Asp 
            20                  25                  30          


Glu Asp Phe Lys His Leu Asp Arg Thr Glu Lys Glu Phe Asn Tyr Tyr 
        35                  40                  45              


Phe Thr Gln Asp Lys Lys Gly Lys Ile Thr Glu Ser Gly Leu Leu Phe 
    50                  55                  60                  


Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Met Gln Gln 
65                  70                  75                  80  


Lys Leu Thr Gly Phe Lys Asp Asn Arg Glu Asn Asn Lys Gln Met Thr 
                85                  90                  95      


His Glu Val Phe Cys Arg Ser Arg Ile Leu Met Pro Lys Leu Arg Leu 
            100                 105                 110         


Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu Asn Glu 
        115                 120                 125             


Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Lys Gly Glu Asp 
    130                 135                 140                 


Arg Lys Lys Phe Glu Val Pro Phe Asp Ser Thr Asp Glu Asp Tyr Asp 
145                 150                 155                 160 


Ala Glu Gln Asp Pro Phe Lys Asn Thr Leu Ile Arg His Gln Asp Arg 
                165                 170                 175     


Phe Pro Tyr Phe Ile Leu Arg Tyr Phe Asp Tyr Asn Glu Ile Phe Lys 
            180                 185                 190         


Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile Tyr 
        195                 200                 205             


Lys Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg His Leu Thr His Lys 
    210                 215                 220                 


Leu Tyr Gly Phe Glu Arg Ile Gln Glu Phe Thr Lys Gln His Arg Pro 
225                 230                 235                 240 


Asp Asp Trp Lys Ala Ile Val Lys Asp Phe Asp Thr Tyr Glu Thr Ser 
                245                 250                 255     


Glu Glu Pro Tyr Ile Ser Glu Thr Thr Pro His Tyr His Leu Glu Asn 
            260                 265                 270         


Gln Lys Ile Gly Ile Arg Phe Lys Asn Asp Asn Asp Lys Ile Trp Pro 
        275                 280                 285             


Ser Leu Glu Thr Asn Gly Glu Asn Asn Glu Lys Ser Lys Tyr Lys Leu 
    290                 295                 300                 


Asp Lys Gln Tyr Gln Ala Glu Ala Phe Leu Ser Val His Glu Leu Leu 
305                 310                 315                 320 


Pro Met Met Phe Tyr Tyr Leu Leu Leu Lys Lys Glu Glu Pro Asn Asn 
                325                 330                 335     


Asp Lys Lys Asn Ala Ser Arg Val Glu Gly Phe Ile Lys Arg Glu Ile 
            340                 345                 350         


Arg Asp Ile Phe Lys Leu Tyr Asp Ala Phe Ala Asn Asp Glu Ile Asn 
        355                 360                 365             


Asn Ile Asp Asp Leu Lys Lys Tyr Tyr Lys Asp Lys Asn Val Glu Ile 
    370                 375                 380                 


Arg His Leu Pro Lys Gln Met Ile Ala Ile Leu Glu Ser Lys Pro Lys 
385                 390                 395                 400 


Asp Met Ala Lys Glu Ala Lys Arg Lys Gln Lys Glu Met Val Lys Asp 
                405                 410                 415     


Thr Lys Lys Leu Leu Ala Thr Leu Glu Lys Gln Thr Gln Lys Glu Lys 
            420                 425                 430         


Glu Asp Asp Gly Arg Asn Val Lys Leu Leu Lys Ser Gly Glu Ile Ala 
        435                 440                 445             


Arg Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln Lys Asp 
    450                 455                 460                 


Asn Glu Gly Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr 
465                 470                 475                 480 


Gln Met Leu Gln Arg Ser Leu Ala Leu Tyr Asn Lys Glu Glu Lys Pro 
                485                 490                 495     


Thr Arg Tyr Phe Arg Gln Val Asn Leu Ile Glu Ser Ser Asn Pro His 
            500                 505                 510         


Pro Phe Leu Lys Trp Thr Lys Trp Glu Glu Cys Asn Asn Ile Leu Thr 
        515                 520                 525             


Phe Tyr His Arg Tyr Leu Thr Lys Lys Ile Glu Phe Leu Asn Lys Leu 
    530                 535                 540                 


Lys Pro Glu Asp Trp Lys Lys Asn Gln Tyr Phe Leu Lys Val Lys Glu 
545                 550                 555                 560 


Pro Lys Thr Asn Arg Glu Thr Leu Val Gln Gly Trp Lys Asn Gly Phe 
                565                 570                 575     


Asn Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg Glu Trp Phe Glu 
            580                 585                 590         


Arg His Gln Asn Asp Ser Glu Glu Tyr Lys Lys Val Glu Lys Leu Asn 
        595                 600                 605             


Lys Ala Gly Leu Val Thr Lys Val Ile Pro Leu Phe Phe Lys Glu Glu 
    610                 615                 620                 


Pro Phe Lys Glu Asp Thr Lys Lys Glu Ile Asn Asp Trp Val Gln Pro 
625                 630                 635                 640 


Phe Tyr Ser Phe Pro Tyr Asn Val Gly Asn Ile His Lys Pro Lys Glu 
                645                 650                 655     


Glu Asp Phe Leu His Arg Glu Glu Arg Ile Glu Leu Trp Asp Lys Lys 
            660                 665                 670         


Lys Asp Lys Phe Lys Gly Tyr Lys Glu Lys Ile Lys Ser Lys Lys Leu 
        675                 680                 685             


Thr Glu Lys Glu Lys Glu Glu Phe Arg Ser Tyr Leu Glu Phe Gln Ser 
    690                 695                 700                 


Trp Asn Lys Phe Glu Arg Glu Leu Arg Leu Val Arg Asn Gln Asp Ile 
705                 710                 715                 720 


Val Thr Trp Leu Leu Cys Lys Glu Leu Ile Asp Lys Leu Lys Ile Asp 
                725                 730                 735     


Glu Leu Asn Ile Glu Glu Leu Lys Lys Leu Arg Leu Asn Asn Ile Asp 
            740                 745                 750         


Thr Asp Thr Ala Lys Lys Glu Lys Asn Asn Ile Leu Asn Arg Val Met 
        755                 760                 765             


Pro Met Glu Leu Pro Val Thr Val Tyr Glu Val Asn Lys Ala Gly Asn 
    770                 775                 780                 


Ile Ile Lys Asp Lys Pro Leu His Thr Ile Tyr Ile Lys Glu Ala Lys 
785                 790                 795                 800 


Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys Asp Arg 
                805                 810                 815     


Arg Leu Asn Gly Leu Phe Ser Phe Val Lys Thr Ser Ser Glu Ala Glu 
            820                 825                 830         


Ser Lys Arg Asn Pro Ile Ser Lys Leu Arg Val Glu His Glu Leu Arg 
        835                 840                 845             


Glu Tyr Gln Lys Ala Arg Ile Glu Ile Ile Lys Asp Met Leu Ala Leu 
    850                 855                 860                 


Glu Lys Thr Leu Ile Asp Asn Tyr Asp Ser Leu Asp Thr Asp Asn Phe 
865                 870                 875                 880 


His Asn Met Leu Thr Gly Trp Leu Lys Leu Lys Gly Glu Val Asn Lys 
                885                 890                 895     


Ala Lys Phe Asn Asn Asp Val Lys Leu Leu Thr Ala Val Arg Asn Ala 
            900                 905                 910         


Phe Ser His Asn Gln Tyr Pro Met Tyr Asp Glu Asn Leu Phe Val Asn 
        915                 920                 925             


Ile Glu Arg Phe Ser Leu Ser Ser Ser Lys Ile Leu Glu Ser Lys Gly 
    930                 935                 940                 


Leu Ser Ile Ala Val Lys Leu Lys Glu Glu Val Ser Lys Ile Ile Lys 
945                 950                 955                 960 


Lys Ile Gln Glu Glu Glu Asp Gly Lys Lys Glu Lys Glu Thr 
                965                 970                 


<210>  2318
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2318

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2319
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2319

Leu Gln Lys Gln Asp Lys Leu Phe Val Asp Arg Lys Lys Asn Ala Ile 
1               5                   10                  15      


Phe Ala Phe Pro Lys Tyr Ile Thr Ile Met Glu Asn Lys Glu Lys Pro 
            20                  25                  30          


Glu Pro Ile Tyr Tyr Glu Leu Thr Asp Lys His Phe Trp Ala Ala Phe 
        35                  40                  45              


Leu Asn Leu Ala Arg His Asn Val Tyr Thr Thr Ile Asn His Ile Asn 
    50                  55                  60                  


Arg Arg Leu Glu Ile Ala Glu Leu Lys Asp Asp Gly Tyr Met Met Gly 
65                  70                  75                  80  


Ile Lys Gly Ser Trp Asn Glu Gln Ala Lys Lys Leu Asp Lys Lys Val 
                85                  90                  95      


Arg Leu Arg Asp Leu Ile Met Lys His Phe Pro Phe Leu Glu Ala Ala 
            100                 105                 110         


Ala Tyr Glu Ile Thr Asn Ser Lys Ser Pro Asn Asn Lys Glu Gln Arg 
        115                 120                 125             


Glu Lys Glu Gln Ser Glu Ala Leu Ser Leu Asn Asn Leu Lys Asn Val 
    130                 135                 140                 


Leu Phe Ile Phe Leu Glu Lys Leu Gln Val Leu Arg Asn Tyr Tyr Ser 
145                 150                 155                 160 


His Tyr Lys Tyr Ser Glu Glu Ser Pro Lys Pro Thr Phe Glu Thr Ser 
                165                 170                 175     


Leu Leu Lys Asn Met Tyr Lys Val Phe Asp Ala Asn Val Arg Leu Val 
            180                 185                 190         


Lys Arg Asp Tyr Met His His Glu Asn Ile Asp Met Gln Arg Asp Phe 
        195                 200                 205             


Thr His Leu Asn Arg Lys Lys Gln Val Gly Arg Thr Lys Asn Ile Ile 
    210                 215                 220                 


Asp Ser Pro Asn Phe His Tyr His Phe Ala Asp Lys Glu Gly Asn Met 
225                 230                 235                 240 


Thr Ile Ala Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Asp Lys Lys 
                245                 250                 255     


Asp Ala Ile Trp Met Gln Lys Lys Leu Lys Gly Phe Lys Asp Gly Arg 
            260                 265                 270         


Asn Leu Arg Glu Gln Met Thr Asn Glu Val Phe Cys Arg Ser Arg Ile 
        275                 280                 285             


Ser Leu Pro Lys Leu Lys Leu Glu Asn Val Gln Thr Lys Asp Trp Met 
    290                 295                 300                 


Gln Leu Asp Met Leu Asn Glu Leu Val Arg Cys Pro Lys Ser Leu Tyr 
305                 310                 315                 320 


Glu Arg Leu Arg Glu Lys Asp Arg Glu Ser Phe Lys Val Pro Phe Asp 
                325                 330                 335     


Ile Phe Ser Asp Asp Tyr Asp Ala Glu Glu Glu Pro Phe Lys Asn Thr 
            340                 345                 350         


Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe 
        355                 360                 365             


Asp Leu Asn Glu Ile Phe Glu Gln Leu Arg Phe Gln Ile Asp Leu Gly 
    370                 375                 380                 


Thr Tyr His Phe Ser Ile Tyr Asn Lys Arg Ile Gly Asp Glu Asp Glu 
385                 390                 395                 400 


Val Arg His Leu Thr His His Leu Tyr Gly Phe Ala Arg Ile Gln Asp 
                405                 410                 415     


Phe Ala Pro Gln Asn Gln Pro Glu Glu Trp Arg Lys Leu Val Lys Asp 
            420                 425                 430         


Leu Asp His Phe Glu Thr Ser Gln Lys Pro Tyr Ile Ser Lys Thr Ala 
        435                 440                 445             


Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Lys Phe Cys Ser 
    450                 455                 460                 


Thr His Asn Asn Leu Phe Pro Ser Leu Lys Arg Glu Lys Thr Cys Asn 
465                 470                 475                 480 


Gly Arg Ser Lys Phe Asn Leu Gly Thr Gln Phe Thr Ala Glu Ala Phe 
                485                 490                 495     


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu 
            500                 505                 510         


Thr Lys Asp His Pro Lys Gly Glu Gly Val Asn Lys Ile Glu Lys Ile 
        515                 520                 525             


Ile Arg Thr Glu Ile Ser Asn Ile Tyr Asp Ile Tyr Asp Ala Phe Ala 
    530                 535                 540                 


Asn Gly Glu Ile Asn Ser Ile Ala Asp Leu Thr Cys Arg Leu Gln Lys 
545                 550                 555                 560 


Thr Asn Ile Leu Gln Gly His Leu Pro Lys Gln Met Ile Ser Ile Leu 
                565                 570                 575     


Glu Gly Arg Gln Lys Asp Met Glu Lys Glu Ala Glu Arg Lys Ile Gly 
            580                 585                 590         


Glu Met Ile Asp Asp Thr Gln Arg Arg Leu Asp Leu Leu Cys Lys Gln 
        595                 600                 605             


Thr Asn Gln Lys Ile Arg Ile Gly Lys Arg Asn Ala Gly Leu Leu Lys 
    610                 615                 620                 


Ser Gly Lys Ile Ala Asp Trp Leu Val Asn Asp Met Met Arg Phe Gln 
625                 630                 635                 640 


Pro Val Gln Lys Asp Gln Asn Asn Ile Pro Ile Asn Asn Ser Lys Ala 
                645                 650                 655     


Asn Ser Thr Glu Tyr Arg Met Leu Gln Arg Ala Leu Ala Leu Phe Gly 
            660                 665                 670         


Ser Glu Asn Phe Arg Leu Lys Ala Tyr Phe Asn Gln Met Asn Leu Val 
        675                 680                 685             


Gly Asn Asp Asn Pro His Pro Phe Leu Ala Glu Thr Gln Trp Glu His 
    690                 695                 700                 


Gln Thr Asn Ile Leu Ser Phe Tyr Arg Asn Tyr Leu Glu Ala Arg Lys 
705                 710                 715                 720 


Lys Tyr Leu Lys Gly Leu Lys Pro Gln Asn Trp Lys Gln Tyr Gln His 
                725                 730                 735     


Phe Leu Ile Leu Lys Val Gln Lys Thr Asn Arg Asn Thr Leu Val Thr 
            740                 745                 750         


Gly Trp Lys Asn Ser Phe Asn Leu Pro Arg Gly Ile Phe Thr Lys Pro 
        755                 760                 765             


Ile Arg Glu Trp Phe Glu Lys His Asn Asn Ser Lys Arg Ile Tyr Asp 
    770                 775                 780                 


Gln Ile Leu Ser Phe Asp Arg Val Gly Phe Val Ala Lys Ala Ile Pro 
785                 790                 795                 800 


Leu Tyr Phe Thr Glu Glu Tyr Lys Asp Asn Val Gln Pro Phe Tyr Asp 
                805                 810                 815     


Tyr Pro Phe Asn Ile Gly Asn Lys Leu Lys Pro Lys Lys Gly Gln Phe 
            820                 825                 830         


Leu Asp Lys Lys Glu Arg Val Glu Leu Trp Gln Lys Asn Lys Glu Leu 
        835                 840                 845             


Phe Lys Asn Tyr Pro Ser Glu Lys Lys Lys Thr Asp Leu Ala Tyr Leu 
    850                 855                 860                 


Asp Phe Leu Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys 
865                 870                 875                 880 


Asn Gln Asp Ile Val Thr Trp Leu Met Phe Lys Glu Leu Phe Asn Met 
                885                 890                 895     


Ala Thr Val Glu Gly Leu Lys Ile Gly Glu Ile His Leu Arg Asp Ile 
            900                 905                 910         


Asp Thr Asn Thr Ala Lys Ala Glu Ser Asn Asn Ile Leu Asn Arg Ile 
        915                 920                 925             


Met Pro Met Lys Leu Pro Val Lys Thr Tyr Glu Ile Asn Asn Lys Gly 
    930                 935                 940                 


Lys Met Glu Met Glu Lys Pro Leu Ala Thr Phe Tyr Ile Glu Glu Thr 
945                 950                 955                 960 


Glu Thr Lys Val Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys Asp 
                965                 970                 975     


Arg Arg Leu Asn Gly Leu Phe Ser Phe Ala Glu Thr Thr Asp Leu Asn 
            980                 985                 990         


Leu Glu Glu His Pro Ile Ser Lys  Leu Ser Val Asp His  Glu Leu Ile 
        995                 1000                 1005             


Lys Tyr  Gln Thr Thr Arg Val  Arg Ile Phe Glu Met  Ile Leu Arg 
    1010                 1015                 1020             


Leu Glu  Lys Lys Leu Ile Asn  Lys Tyr Pro Thr Leu  Pro Thr Tyr 
    1025                 1030                 1035             


Ser Phe  Lys Asn Met Leu Glu  Ser Trp Leu Glu Asp  Lys Thr Asn 
    1040                 1045                 1050             


Ser Ala  Glu Leu Asn Asn Tyr  Val Asp Cys Leu Ile  Ala Val Arg 
    1055                 1060                 1065             


Asn Ala  Phe Ala His Asn Gln  Tyr Pro Met Tyr Asn  Pro Lys Leu 
    1070                 1075                 1080             


Phe Ala  Glu Val Lys Lys Phe  Ser Leu Phe Pro Ser  Ser Asn Thr 
    1085                 1090                 1095             


Lys Lys  Ile Glu Leu Asn Ile  Ala Pro Gln Leu Leu  Glu Ile Val 
    1100                 1105                 1110             


Gly Lys  Ala Ile Lys Glu Ile  Glu Lys Ser Glu Asn  Lys Asn 
    1115                 1120                 1125         


<210>  2320
<211>  1152
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2320

Met Thr Leu Pro Thr Asp Asn Thr Phe Ile Glu Arg Pro Asp Glu Lys 
1               5                   10                  15      


Ile Leu Tyr Gln Asn Lys Leu Phe Phe Gly Ala Tyr Leu Asn Met Ala 
            20                  25                  30          


Gln His Asn Ala Tyr Leu Ile Ile Lys Asp Ile Ser Glu Gln Phe Gly 
        35                  40                  45              


Leu Asp Ile Ser Thr Leu Gln Glu Asn Gln Leu Glu Ser Ala Asp Leu 
    50                  55                  60                  


Ile Lys Lys Leu Lys Gly Lys Gly Gly Arg Pro Lys Asn Ser Val Gln 
65                  70                  75                  80  


Met Thr Asn Ala Leu Val Arg Arg Leu Pro Phe Leu Glu Ala Met Lys 
                85                  90                  95      


Ala Pro Glu Glu Ser Thr Tyr Lys Ala Gly Thr Glu Lys Glu Lys Glu 
            100                 105                 110         


Val Ile His Ala Lys Glu Ile Gln Ser Gly Glu Val Gly Lys Ile Leu 
        115                 120                 125             


Thr Thr Ala Phe Glu Phe Met Gly Gln Leu Arg Asn Phe Tyr Ser His 
    130                 135                 140                 


Tyr His His Glu Asp Val Asp Phe Lys Asp Phe Ser Val Ile Glu Ile 
145                 150                 155                 160 


Ile Phe Asp Asn Ala Ile Lys Arg Ala Ile Lys Arg Ile Pro Asp Val 
                165                 170                 175     


Asn Glu Glu Asn Thr Asn His Leu Leu Asn Ala Pro Thr Tyr Ala Met 
            180                 185                 190         


Tyr Lys Asp Gly Lys Leu Thr Asn Leu Gly Leu Thr Phe Phe Ile Cys 
        195                 200                 205             


Leu Phe Leu Glu Arg Lys Tyr Ala Tyr Leu Phe Leu Met Gln Leu Glu 
    210                 215                 220                 


His Phe Lys Gly Gln Asn Asp Phe Val Tyr Ser Asn Arg Arg Cys Phe 
225                 230                 235                 240 


Thr Asp Leu Ser Cys Asn Leu Pro Lys Pro Lys Leu Gly Ser Ser Glu 
                245                 250                 255     


Ile Glu Met Asp Ile Leu Gly Glu Leu Ala Arg Cys Pro Lys Glu Leu 
            260                 265                 270         


Phe Tyr Arg Leu Ser Glu Glu Asp Lys Asn Lys Phe Phe Ala Glu Gln 
        275                 280                 285             


Lys Glu Thr Glu Asp Glu Ile Pro Pro Pro Ile Met Lys Arg Lys Asp 
    290                 295                 300                 


Asp Arg Phe Ala Ser Phe Ala Leu Arg Tyr Leu Glu Glu Lys Arg Leu 
305                 310                 315                 320 


Asn Lys Met Arg Phe Gln Ile His Leu Gly Lys Val Arg Arg Ile Gly 
                325                 330                 335     


Glu Lys His Gln Tyr Asp Lys Thr Ile Ala Gly Val Glu Ala Glu Arg 
            340                 345                 350         


Val Ile Met Glu Asn Leu Arg Thr Phe Ala Lys Leu Ser Glu Thr Asn 
        355                 360                 365             


Thr Glu Lys Thr Pro Glu His Trp Arg Val Phe Asn Arg Asp Thr Asn 
    370                 375                 380                 


Lys Lys Asp Leu Ile Arg Thr Glu Ile Glu Gln Phe Arg Pro Arg His 
385                 390                 395                 400 


Gln Ile Thr Gly Asn Arg Ile Ala Leu Lys Phe Leu Thr Glu Glu Arg 
                405                 410                 415     


Asn Ser Val Phe Pro Asp Leu Lys Phe Asp Asn Asn Gln Thr Lys Leu 
            420                 425                 430         


Gln Ala Leu Asp Thr Pro Asp Ala Ile Leu Ser Thr Tyr Glu Leu Gln 
        435                 440                 445             


Asn Leu Val Met Tyr Asp Gln Leu His Lys Glu Gly Ala Ile Glu Lys 
    450                 455                 460                 


Asp Val Glu Thr Phe Ile Ala Asp Tyr Ile Leu Asn Phe Arg Lys Phe 
465                 470                 475                 480 


Cys Glu Ala Val Asp Lys Gly Glu Val Thr Pro Val Ala Asp Ala Asp 
                485                 490                 495     


Phe Ile Lys Val Val Lys Ala Ser Gly Lys Ser Lys Pro Glu Tyr Ser 
            500                 505                 510         


Glu Ala Gln Leu Val Glu Leu Lys Asn Arg Gln Gln Ser Leu Lys Gly 
        515                 520                 525             


Ile Leu Thr Asn Tyr Gly Leu Gln Ile Gln Gln Leu Pro Asp Asn Leu 
    530                 535                 540                 


Arg Glu Tyr Leu Leu Gly Tyr Ala Pro Val Asn Tyr Lys Arg Glu Ala 
545                 550                 555                 560 


Leu Arg Ile Leu Glu Thr Lys Phe Ser Glu Thr Leu Lys Leu Arg Thr 
                565                 570                 575     


Asp Ser Gln Lys Gly Phe Gly Pro Lys Val Gly Glu Met Ala Thr Phe 
            580                 585                 590         


Leu Ala Arg Asp Ile Asn His Leu Lys Pro Pro Arg Glu Trp Lys Asp 
        595                 600                 605             


Ser Lys Val Arg Leu Asn Asp Glu Gln Tyr Asp Asn Leu Gln Ala Ala 
    610                 615                 620                 


Ile Ser Gln Phe Ser Gly Gln Ile Pro Gln Ile Glu Ala Leu Phe Asp 
625                 630                 635                 640 


Glu Leu Glu Leu Thr Lys Ser Tyr Ser Arg Ser Arg Ala Glu Asn Glu 
                645                 650                 655     


Ala Leu Gln Ala Leu Met His Pro Phe Leu Phe Arg Ile Lys Leu Gln 
            660                 665                 670         


Asp Ser Ala Asn Gln Gly Gly Ile His Ile Phe Tyr Gln Arg Tyr Leu 
        675                 680                 685             


Asn Lys Lys Ala Asp Trp Leu Gln Gly Leu Met Leu Leu Leu Lys Gln 
    690                 695                 700                 


Glu Pro Tyr Gly Asp Phe Gly Pro Phe Asn Asn Phe Pro Glu Gly Tyr 
705                 710                 715                 720 


Gln Asn Ile Ser Leu Pro Glu Phe Thr Lys Lys Phe Asp Tyr Val Leu 
                725                 730                 735     


Arg Ile Asp Lys Lys Leu Asn Arg Lys Lys Gln Tyr Leu Phe Ser Asp 
            740                 745                 750         


Lys Glu Lys Thr Gln Lys Ser Ala Ile Phe Leu Pro Arg Gly Leu Phe 
        755                 760                 765             


Asn Ala Pro Ile Met Glu Ala Leu Phe Phe Lys Lys Asn Ile Glu Val 
    770                 775                 780                 


Glu Pro Asp Asp Ser Leu Val Met Ala Met Ser Lys Tyr Lys Pro Asp 
785                 790                 795                 800 


Ser Gln Ser Phe Tyr Asn Phe Glu Arg Ile Tyr Thr Leu Lys Gly Arg 
                805                 810                 815     


Asp Glu Ala Pro Asp Thr Leu Tyr Thr Gly Asp Ala Asn Gln Ile Gly 
            820                 825                 830         


Ala Gln Met Gln Val Leu Lys Lys Glu Ile Glu Gln Met Gln Ser Lys 
        835                 840                 845             


Arg Lys Ala Met Ser Leu Pro Ala Asp Trp Trp Glu Thr Tyr Ser Gln 
    850                 855                 860                 


Lys Asn Lys Gly Lys Lys Lys Lys Glu Glu Leu Thr Ser Ile Gln Lys 
865                 870                 875                 880 


Thr Ala Gln Asn Leu Glu Tyr Gln Ile Asn Asp Leu Lys Lys Phe Arg 
                885                 890                 895     


Arg Ser Val Met Thr Asn Glu Gln Thr Leu Arg Tyr Arg Gln Thr Asn 
            900                 905                 910         


Asp Arg Val Leu Trp Leu Ile Val Lys Asn Tyr Phe Glu Asp Ile Asp 
        915                 920                 925             


Ser His Phe Asn Ile Asp Ile Ser Glu Trp Glu Leu His Asn Val Gly 
    930                 935                 940                 


Phe Glu Ile Lys Glu Lys Asn Val Leu Asn Thr Lys Ile Asp Leu Ser 
945                 950                 955                 960 


Phe Pro Leu Tyr Gly Tyr Thr Ile His Thr Lys Gln Ser Glu Gly Glu 
                965                 970                 975     


Asn Val Pro Val His Glu Ser Asp His Leu Thr Ile Lys Arg Tyr Gly 
            980                 985                 990         


Glu Phe Arg Tyr Val Leu Lys Asp  Arg Arg Leu Trp Ser  Glu Lys Val 
        995                 1000                 1005             


His Gln  Asp Gly Asn Ile Glu  Lys Thr Gly Ile Leu  Arg Tyr Tyr 
    1010                 1015                 1020             


Ser Pro  Asp Thr Pro Ile Ala  Trp Ser Ile Leu Lys  Arg Glu Leu 
    1025                 1030                 1035             


Asp Thr  Tyr Asp Gly Glu Asp  Arg His Lys Leu Met  Asn His Ile 
    1040                 1045                 1050             


His Ala  Phe Glu Tyr Asp Met  Tyr Thr Met His Glu  Glu Lys Met 
    1055                 1060                 1065             


Glu Arg  Glu Ser Gly Ala Lys  Ile Ile Asn His Leu  Lys Gln Leu 
    1070                 1075                 1080             


Glu Ala  Val His Asn Tyr Ile  Ala Gln Ile Asp Lys  Pro Asn His 
    1085                 1090                 1095             


Leu Met  Ile Asn Glu Leu Arg  Ser Lys Phe Met His  Asn Gln Ile 
    1100                 1105                 1110             


Pro Phe  Asn Ala Trp Leu Glu  Asn Glu Leu Lys Asn  Thr Pro Lys 
    1115                 1120                 1125             


Gly Ser  Lys Val Lys Gln Leu  Leu Asp Ile Ala Thr  Lys Ala Tyr 
    1130                 1135                 1140             


His Asn  Ile Ile Thr Gln Ile  Asn Gln 
    1145                 1150         


<210>  2321
<211>  985
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2321

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Asn Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys Gly Tyr 
                165                 170                 175     


Ala Phe Phe Ile Ser Lys Phe Leu Glu Arg Lys Tyr Ser Tyr Leu Phe 
            180                 185                 190         


Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln Tyr Arg 
        195                 200                 205             


Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro Val Glu 
    210                 215                 220                 


Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu Asp Ile 
225                 230                 235                 240 


Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr Leu Glu 
                245                 250                 255     


Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr Asp Ala 
            260                 265                 270         


Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe Arg Ser 
        275                 280                 285             


Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala Asp Phe 
    290                 295                 300                 


Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His Asn Gly 
305                 310                 315                 320 


Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr Ile Asn 
                325                 330                 335     


Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser Ala Lys 
            340                 345                 350         


Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser Thr Asp 
        355                 360                 365             


Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln Ser Thr 
    370                 375                 380                 


Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val Leu Pro 
385                 390                 395                 400 


Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala Lys Met 
                405                 410                 415     


Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala Met Leu 
            420                 425                 430         


Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His Cys Pro 
        435                 440                 445             


Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser Thr Lys 
    450                 455                 460                 


Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg Val Met 
465                 470                 475                 480 


Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu Arg Ile 
                485                 490                 495     


Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile Leu Lys 
            500                 505                 510         


Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp Leu Gln 
        515                 520                 525             


Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn Phe Gln 
    530                 535                 540                 


Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn Asp Leu 
545                 550                 555                 560 


Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn Pro His 
                565                 570                 575     


Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile Glu Phe 
            580                 585                 590         


Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg Ile Gln 
        595                 600                 605             


Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro Leu Arg 
    610                 615                 620                 


Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu Ala Ile 
625                 630                 635                 640 


Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys Leu Lys 
                645                 650                 655     


Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu Lys Ser 
            660                 665                 670         


Pro Ala Leu Asn Val Ser Tyr Leu Ile His Asn Tyr Phe Arg Ala Tyr 
        675                 680                 685             


Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn Tyr Arg 
    690                 695                 700                 


Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser Tyr Leu 
705                 710                 715                 720 


Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro Ser Lys 
                725                 730                 735     


Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp Arg Leu 
            740                 745                 750         


Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile Ile Arg 
        755                 760                 765             


Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys Glu Tyr 
    770                 775                 780                 


Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu Glu Asn 
785                 790                 795                 800 


Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp Leu Asn 
                805                 810                 815     


Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr Gly Lys 
            820                 825                 830         


Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn Lys Val 
        835                 840                 845             


Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val Lys Ile 
    850                 855                 860                 


Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu Glu Ala 
865                 870                 875                 880 


Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala Met Val 
                885                 890                 895     


Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr Tyr Asp 
            900                 905                 910         


Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln Lys Ile 
        915                 920                 925             


Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His Asp Lys 
    930                 935                 940                 


Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val Tyr Ala 
945                 950                 955                 960 


Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile Lys Leu 
                965                 970                 975     


Glu Asp Leu Ser Asn Asp Ser Ser Ala 
            980                 985 


<210>  2322
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2322

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Ala Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Asn Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Ala Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2323
<211>  1146
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2323

Met Glu Ile Lys Glu Lys Thr Glu Lys Arg Phe Leu Ala Val Phe Leu 
1               5                   10                  15      


Asn Lys Gly Asn Met Gly Pro Ile Ala Glu Lys Ala Val Lys Asn Phe 
            20                  25                  30          


Asp Thr Ile Asn Gln His Asp Val Ser Leu Lys Glu Arg Ile His His 
        35                  40                  45              


Phe Ala Ile Gly His Ala Phe Arg Asn Val Asp Lys Ala Ile Phe Glu 
    50                  55                  60                  


Tyr Glu Leu Val Glu Ser Lys Glu Lys Leu Leu Pro Ser Arg Phe Ile 
65                  70                  75                  80  


Asn Leu Gln Leu Asp Arg Phe Pro Ser Thr Lys Arg Leu Phe Asp Val 
                85                  90                  95      


Ile Lys Asn Ile Arg Asn Cys Asn Gly His Tyr Val His Ala Phe Asp 
            100                 105                 110         


Lys Leu Ser Ile Asn Glu Met Asp Lys Arg Glu Asn Asn Ser Asp Thr 
        115                 120                 125             


Asn Arg Val Glu Ala Lys Ile Ile Asp Phe Leu Lys Glu Ala Phe Glu 
    130                 135                 140                 


Phe Ser Val Met Ile His Tyr Leu Lys Glu Asn Glu Leu His Tyr Glu 
145                 150                 155                 160 


Asp Phe Lys Ala Thr Thr Asp Lys Asp Thr Lys Leu Val Thr Tyr Leu 
                165                 170                 175     


Cys Asn Lys Phe Phe Pro Asn Ile Val His Gln Glu Asp Val Arg Glu 
            180                 185                 190         


Ser Phe Ile Lys Leu Asn Phe Lys Glu Ala Leu Asp Glu Leu Leu Phe 
        195                 200                 205             


Ile Glu Val Asp Glu Asp Phe Glu Trp Lys Ile Asp Gly Val His Lys 
    210                 215                 220                 


Val Phe Asp Ile Lys Gln Gly Lys Tyr Leu Ser Phe Val Gly Gln Leu 
225                 230                 235                 240 


Phe Leu Leu Ser Leu Phe Leu Tyr Lys His Glu Ala Asn Gln Leu Ile 
                245                 250                 255     


Ser Lys Ile Lys Gly Phe Lys Arg Asn Asp Asp Glu His His Tyr Lys 
            260                 265                 270         


Arg Asp Ile Phe Thr Phe Phe Ser Lys Lys Val Ser Ser Gln Asp Ile 
        275                 280                 285             


His Ser Glu Glu Lys His Leu Ile Gln Phe Arg Asp Ile Ile Gln Tyr 
    290                 295                 300                 


Leu Asn His Phe Pro Thr Glu Trp Asn Glu Tyr Leu Ser Pro Lys Arg 
305                 310                 315                 320 


Leu Asn Leu Ser Met Thr Asp Gln Leu Glu Lys Tyr Ile Ile Glu Thr 
                325                 330                 335     


Glu Ile Phe Ser Val Phe Pro Lys Tyr Lys Asn Cys Lys Arg Glu Leu 
            340                 345                 350         


Phe Leu Lys Tyr Ala Ile Ser Arg Leu Phe Pro Asp Lys Leu Asp Leu 
        355                 360                 365             


Phe Asp Ala His Ser Leu Thr Met Asp Asp Lys Leu Lys Lys Asp Phe 
    370                 375                 380                 


Asp Tyr Glu Ile Asp Ala Ser Pro Glu Leu Lys Asn Val Asp Leu Lys 
385                 390                 395                 400 


Leu Thr Ile Arg Leu Lys Pro His Asp Phe Asn Lys Gln Ile Lys Arg 
                405                 410                 415     


Lys Arg Lys Leu Glu Lys Glu Val Asn Pro Asn Lys Leu Lys Leu Gln 
            420                 425                 430         


Lys Lys Val Gln Glu Asp Lys Leu Leu Val Met Tyr Gly Arg Asn Gln 
        435                 440                 445             


Asp Arg Phe Met Glu Phe Ala Val Arg Phe Leu Ala Glu Glu Ser Tyr 
    450                 455                 460                 


Phe Gly Lys Asp Ala Glu Phe Lys Met Tyr Arg Phe Tyr Ser Ser Asp 
465                 470                 475                 480 


Glu Gln Asn Asp Phe Leu Arg Lys Gln Lys Glu Glu Ser Ser Lys Lys 
                485                 490                 495     


Glu Ile Asp Gly Asn Lys Tyr His Gln Gly Arg Leu Thr His Tyr Ile 
            500                 505                 510         


Thr Tyr Ser Glu His Lys Glu Arg Tyr Pro Ser Trp Asp Asn Ser Phe 
        515                 520                 525             


Val Phe Gln Asn Asn Ala Phe Gln Leu Ile Leu Ser Leu Ser Asn Gly 
    530                 535                 540                 


Glu Lys Arg Lys Phe Ser Ile Gln Arg Lys Leu Leu Ile Tyr Leu Leu 
545                 550                 555                 560 


Glu Asp Ala Leu Tyr Gly Ser Ser Gly Ser Ile Glu Gly Lys Gly Lys 
                565                 570                 575     


Gln Leu Val Glu Asp Tyr Phe Leu Asn Tyr Leu Met Pro Asp Phe Glu 
            580                 585                 590         


Glu Ala Lys Asn Thr Tyr Ser Gly Glu Thr Leu Asn Ala Lys His Arg 
        595                 600                 605             


Gln Leu Leu Pro Lys Arg Leu Leu Tyr Thr Tyr His Pro Pro Val Gln 
    610                 615                 620                 


Asn Asn Gly Val Gly Asn Ser His Pro Phe Glu Lys Ile Leu Asn Glu 
625                 630                 635                 640 


Thr Glu Gln Gln Glu Lys Arg Tyr Leu Ala Leu Gln Gln Lys Ala Lys 
                645                 650                 655     


Ser Leu Gly Ile Glu Glu Glu Phe Leu Lys Arg Asn Lys Gly Lys Gln 
            660                 665                 670         


Phe Lys Leu Arg Phe Ile Arg Lys Ala Trp His Leu Met Tyr Phe Lys 
        675                 680                 685             


Glu Ser Tyr Gln Lys Gln Ala Glu Val Leu Gly His His Lys Gly Phe 
    690                 695                 700                 


His Ile Thr Lys Asp Glu Phe Asp Asp Phe Ser Lys Trp Met Phe Ala 
705                 710                 715                 720 


Phe Asp Glu Val Pro Gln Tyr Lys Val Tyr Leu Lys Arg Leu Leu Glu 
                725                 730                 735     


Ser Lys Gln Phe Leu Asp Asn Ser Glu Phe Ala His Leu Phe Asp Gln 
            740                 745                 750         


Gly Arg Ser Leu Asn Asp Phe Tyr Val Thr Thr Lys Lys Glu Phe Glu 
        755                 760                 765             


Arg Arg Leu Lys Glu Asn Leu Phe Gln Leu Asp Lys Asn Thr Glu Ser 
    770                 775                 780                 


Gly Gln Tyr Asp Glu Ile Leu Ser Lys Lys Leu Val Tyr Ile Asn Val 
785                 790                 795                 800 


Ser His Phe Ile Asn Tyr Leu Lys Phe Lys Asp Lys Ile Lys Glu Gln 
                805                 810                 815     


Asn Gly Val Ile Arg Tyr Ala Ala Leu Asp Asn Ile Lys Tyr Leu Ile 
            820                 825                 830         


Lys Glu Tyr Tyr Tyr Ala Asp Val Leu Pro Lys Glu Gln Tyr Lys Glu 
        835                 840                 845             


Asn Gly Lys Leu Phe Asn Lys Leu Arg Thr Ala Lys Leu Glu Asp Ala 
    850                 855                 860                 


Leu Leu Tyr Glu Leu Ala Met Lys Tyr Leu Lys Thr Asp Lys His Ile 
865                 870                 875                 880 


Val Gln Lys Val Arg Thr Asn Val Val Asp Ile Leu Thr Ser Lys Val 
                885                 890                 895     


Ile Phe Asp Ile Lys Asp Ala Trp Gly Asn His Leu Tyr Asn Leu Val 
            900                 905                 910         


Val Pro Phe Ser Lys Leu Glu Thr Leu Ala Val Leu Leu Arg Tyr Lys 
        915                 920                 925             


Thr Ser Gln Glu Glu Ile Asp Asp Asn Asn Arg Thr Ser Tyr Leu Gly 
    930                 935                 940                 


Asn Ile Tyr Gln Leu Leu Thr Phe Leu Lys Asp Lys Ile Asn Asn Cys 
945                 950                 955                 960 


Lys Asp Asp Asp Lys Lys Lys Ser Asn Lys Tyr Gly Asp Ile Leu Arg 
                965                 970                 975     


Ile Val Glu Cys Phe Asn Lys His Asn Val Gln Arg Lys Leu Thr Phe 
            980                 985                 990         


Glu Asp Leu Asn Ser Ile Asn Asn  Tyr Ile Ile Ser Gly  Ala Val Glu 
        995                 1000                 1005             


Phe Ser  Lys Ile His Met Glu  Leu Glu Lys Tyr Phe  Ile Leu Lys 
    1010                 1015                 1020             


Tyr Lys  Ile Glu Ser Pro Lys  Phe Ile Asp Ile Lys  Lys Ile Lys 
    1025                 1030                 1035             


Asn Glu  Lys Gly Val Gln Ile  Phe Glu Ile Tyr Tyr  Glu Ser Ile 
    1040                 1045                 1050             


Pro Glu  Ile Arg Arg Lys Ala  Tyr His Phe Gly Val  Pro Glu Arg 
    1055                 1060                 1065             


Phe Ile  Tyr Glu Gln Glu Asn  Lys Lys Thr Glu Ala  Lys Phe Ile 
    1070                 1075                 1080             


Gln Glu  Glu Val Lys Pro Gln  Gly Val Leu Glu Phe  Lys Asp Leu 
    1085                 1090                 1095             


Ser Arg  Glu Thr Lys Thr Val  Cys Arg Val Phe Met  Asn Ile Leu 
    1100                 1105                 1110             


His Ala  Asn Leu Phe Val Arg  Asp Lys Asn Lys Ser  Asp Glu Glu 
    1115                 1120                 1125             


Lys Lys  Asn Asp Phe Glu Lys  Arg Tyr Phe Lys Glu  Val Ile Gln 
    1130                 1135                 1140             


Asn Val  Lys 
    1145     


<210>  2324
<211>  1196
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2324

Met Lys Thr Ser Lys Glu Phe Glu Asn Tyr Asn Ser Arg Asn Ser Phe 
1               5                   10                  15      


Lys Lys Ile Phe Asp Phe Lys Gly Glu Ile Ala Pro Ile Ala Glu Lys 
            20                  25                  30          


Ala Asn Arg Asn Leu Glu Leu Lys Thr Lys Asn Glu Thr Asn Leu Val 
        35                  40                  45              


Gln Arg Val His Tyr Phe Ala Ile Gly His Thr Phe Lys Tyr Ile Asp 
    50                  55                  60                  


Thr Glu Thr Leu Phe Glu Trp Val Val Asp Glu Glu Thr Gln Met Lys 
65                  70                  75                  80  


Gln Pro Thr Lys Phe Leu Ser Leu Gln Ser Phe Asp Asp Ser Phe Cys 
                85                  90                  95      


Asp Glu Leu Gln Lys Ile Thr Val Val Gly Thr Asn Asn Glu Tyr Asn 
            100                 105                 110         


Gly Leu Ile Pro Ala Ile Arg Asn Ile Asn Ser His Tyr Ile His Ser 
        115                 120                 125             


Phe Glu Lys Ile Arg Ile Asp Ser Leu Ser Pro Val Met Val Lys Phe 
    130                 135                 140                 


Leu Lys Glu Ser Phe Glu Leu Ser Val Ile Gln Ile Tyr Ile Lys Glu 
145                 150                 155                 160 


Glu Asn Glu Leu Lys Arg Ser Lys Asn Glu Arg Leu Ala Ser Thr Lys 
                165                 170                 175     


Glu Ile Ile Glu Gln Asn Gly Phe Gly Lys Arg Leu Val Gln Phe Leu 
            180                 185                 190         


Cys Asp Lys Phe Tyr Pro Val Gly Asn Lys Thr Thr Tyr Pro Glu Asp 
        195                 200                 205             


Tyr Leu Glu Tyr Arg Lys Gln Phe Arg Asn Leu Ser Lys Asp Glu Ala 
    210                 215                 220                 


Ile Asp Ser Leu Leu Phe Val Glu Val Glu Thr Ala Phe Asp Trp Leu 
225                 230                 235                 240 


Leu Phe Glu Thr Tyr Pro Ala Phe Asn Ile Ala Val Gly Lys Tyr Leu 
                245                 250                 255     


Ser Phe Tyr Ser Cys Leu Phe Leu Leu Ser Met Phe Leu Tyr Lys Ser 
            260                 265                 270         


Glu Ala Asn Gln Leu Ile Ser Lys Ile Lys Gln Phe Lys Arg Asn Lys 
        275                 280                 285             


Ile Gln Glu Glu Lys Ser Lys Arg Glu Ile Phe Thr Phe Phe Ser Lys 
    290                 295                 300                 


Arg Phe Ser Ser Gln Asp Ile Asp Ser Glu Glu Asn His Leu Val Lys 
305                 310                 315                 320 


Phe Arg Asp Leu Ile Gln Tyr Leu Asn Arg Tyr Pro Val Ala Trp Asn 
                325                 330                 335     


Lys Asp Ile Glu Leu Glu Ser Gln His Pro Val Met Thr Asp Arg Leu 
            340                 345                 350         


Lys Ala Lys Ile Ile Glu Met Glu Ile Asp Ser Ser Phe Pro Ile Tyr 
        355                 360                 365             


Ala Glu Asn Asn Arg Phe His Val Phe Ala Lys Tyr Gln Ile Trp Gly 
    370                 375                 380                 


Lys Lys Tyr Phe Gly Lys Lys Ile Glu Lys Glu Tyr Ile Glu Gln Ser 
385                 390                 395                 400 


Phe Asn Gly Asn Glu Val Glu Glu Phe Ser Tyr Glu Ile Asn Thr Ser 
                405                 410                 415     


Pro Glu Leu Lys Gly Phe Tyr Leu Lys Leu Ala Asp Leu Lys Ser Lys 
            420                 425                 430         


Pro Gly Leu Tyr Glu Lys His Lys Ala Glu Ile Lys Arg Thr Glu Thr 
        435                 440                 445             


Ser Ile Lys Glu Leu Ile Glu Gln Asn Val Pro Asn Pro Ile Thr Glu 
    450                 455                 460                 


Lys Leu Lys Thr Arg Ile Glu Lys Asn Leu Leu Phe Val Ser Tyr Gly 
465                 470                 475                 480 


Arg Asn Gln Asp Arg Phe Met Asp Phe Ala Thr Arg Tyr Leu Ala Glu 
                485                 490                 495     


Thr Asn Tyr Phe Gly Asn Asp Ala Arg Phe Lys Met Tyr Gln Phe Tyr 
            500                 505                 510         


Thr Thr Thr Glu Gln Asn Lys Glu Tyr Glu Asn Leu Lys Glu Val Lys 
        515                 520                 525             


Ser Lys Lys Glu Ile Asp Arg Leu Lys Phe His His Gly Arg Pro Ile 
    530                 535                 540                 


His Phe Ser Thr Tyr Ser Asn His His Lys Arg Tyr Glu Ser Trp Asp 
545                 550                 555                 560 


Thr Pro Phe Val Phe Glu Asn Asn Ala Ile Gln Val Lys Met Thr Leu 
                565                 570                 575     


Asp His Gly Ile Glu Lys Thr Val Ser Ile Gln Arg Ser Leu Met Val 
            580                 585                 590         


Tyr Leu Leu Glu Asp Ala Leu Phe Lys Ala Asp Lys Ser Met Val Asp 
        595                 600                 605             


Ser Ala Gly Lys His Leu Ile Ser Glu Tyr Phe Thr His Gln Gln Gln 
    610                 615                 620                 


Asp Phe Asn Tyr Ser Arg Leu Val Leu Glu Gln Asn Glu Ser Ile Asn 
625                 630                 635                 640 


Thr Glu Gln Lys Asn Lys Phe Lys Lys Ile Leu Pro Lys Arg Leu Leu 
                645                 650                 655     


Asn His Tyr Leu Pro Ala Ile Gln Asn Asn Thr Pro Ala Phe Ser Thr 
            660                 665                 670         


Leu Gln Leu Ile Leu Glu Lys Ala Lys Leu Ala Glu Glu Arg Tyr Lys 
        675                 680                 685             


Lys Leu Thr Glu Lys Val Lys Thr Glu Gly Asn Tyr Asp Asp Phe Ile 
    690                 695                 700                 


Lys Arg Asn Lys Gly Lys Gln Phe Lys Leu Gln Phe Ile Arg Lys Ala 
705                 710                 715                 720 


Trp His Leu Met Tyr Phe Lys Glu Ser Tyr Lys Gln Gln Ala Ser Phe 
                725                 730                 735     


Ser Gly His His Lys Arg Phe His Ile Glu Arg Asp Glu Phe Asn Asp 
            740                 745                 750         


Phe Ser Arg Phe Met Phe Ala Phe Asp Glu Val Pro Ala Tyr Lys Asp 
        755                 760                 765             


Tyr Leu Lys Gln Leu Leu Asp Lys Lys Gly Phe Phe Glu Asn Gln Gln 
    770                 775                 780                 


Phe Lys Ala Leu Phe Glu Asn Gly Thr Ser Leu Asp Asn Leu Tyr Val 
785                 790                 795                 800 


Lys Thr Lys Gln Ala Tyr Glu Lys Trp Leu Ile Gly Gln Asn Asn Arg 
                805                 810                 815     


Glu Leu Glu Ala Thr Lys Tyr Thr Leu Gln Ser Tyr Glu Gln Phe Phe 
            820                 825                 830         


Ala Asp Asp Met Phe Tyr Ile Asn Gln Ser His Phe Ile Ser Phe Leu 
        835                 840                 845             


Glu Ser Lys Ser Leu Leu Ser Arg Asp Glu Gln Gly Gln Met Arg Phe 
    850                 855                 860                 


Asn Ala Leu Ala Asn Cys Ala Phe Leu Val Ser Glu Phe Tyr Tyr Thr 
865                 870                 875                 880 


Asp Lys Leu Asp Lys Thr Glu Tyr Lys Thr Asn Arg Lys Leu Phe Asn 
                885                 890                 895     


Gln Leu Arg Ser Val Arg Leu Glu Asp Ala Leu Leu Tyr Glu Met Ala 
            900                 905                 910         


Met Cys Tyr Leu Lys Ile Asp Gln Gln Val Val Gln Lys Ala Lys Ala 
        915                 920                 925             


His Val Ile Glu Ile Leu Thr Gln Asn Val Gln Phe Asp Ile Cys Asn 
    930                 935                 940                 


Ser Gln Asp Lys Leu Val Tyr His Leu Val Ile Pro Phe Asn Lys Ile 
945                 950                 955                 960 


Asp Ala Tyr Val Glu Leu Leu Asn Arg Lys Glu Thr Asp Glu Thr Ile 
                965                 970                 975     


Ser Ser Gly Ser Ser Phe Ile Thr Asn Val Asp Lys Tyr Ile Glu Met 
            980                 985                 990         


Ile Trp Asn Glu Ile Pro Trp Lys  Glu Lys Asn Glu Asn  Ala Lys Lys 
        995                 1000                 1005             


Ile Thr  His Ala Ala Met Tyr  Pro Ile Gly Glu Lys  Tyr Ser Arg 
    1010                 1015                 1020             


Gln Lys  Thr Ile Thr Tyr Asp  Asp Leu Gln Lys Ile  Tyr Gln His 
    1025                 1030                 1035             


Leu Leu  Ser Ser Ser Asn Lys  Leu Thr Asn Val Ser  Met Gln Ile 
    1040                 1045                 1050             


Glu Arg  Tyr Tyr Leu Cys Lys  Pro Asp Gly Gln Gly  His Val Val 
    1055                 1060                 1065             


Phe Asn  Gly Glu Thr Asp Arg  Lys Thr Gly Cys Tyr  Leu Ile Arg 
    1070                 1075                 1080             


Phe Glu  Lys Thr Gly Val Pro  Lys Thr Tyr Phe Gly  Val Gly Glu 
    1085                 1090                 1095             


Leu Asn  Ile Arg Asn Lys Ala  Phe His Phe Leu Ile  Thr Pro Ser 
    1100                 1105                 1110             


Lys Ser  Tyr Glu Lys Trp Leu  Met Asp Val Glu Arg  Glu Phe Ile 
    1115                 1120                 1125             


Leu Lys  Glu Val Lys Pro Asn  Asn Pro Lys Ala Tyr  Thr Asp Leu 
    1130                 1135                 1140             


Asn Arg  Ser Val Lys Leu Val  Cys Asp Ile Leu Leu  Asn Thr Leu 
    1145                 1150                 1155             


His Asn  Asn Tyr Phe Lys Leu  Thr Asp Ser Asp Lys  Gly Ile Pro 
    1160                 1165                 1170             


Lys Glu  Glu Gln Gly Lys Gln  Lys Gln Lys Asn Ala  Gln Ile Thr 
    1175                 1180                 1185             


Tyr Phe  Thr Lys His Ile Leu  Tyr 
    1190                 1195     


<210>  2325
<211>  1165
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2325

Met Thr Pro Ala Asn Pro Lys Ile Asn Glu Ile Leu Arg Lys His Asn 
1               5                   10                  15      


Cys Glu Gln Ser Phe Asn Lys Ile Ser Gln Phe Lys Gly Glu Ile Ala 
            20                  25                  30          


Pro Ile Ala Glu Lys Ser Ala Arg Asn Leu Lys Gln Lys Leu Lys Asn 
        35                  40                  45              


Pro Val Asn Gln Glu Gln Arg Leu His His Phe Thr Ile Gly His Lys 
    50                  55                  60                  


Phe Lys Leu Leu Asp Lys Glu His Ile Phe Gln Tyr Lys Val Asp Glu 
65                  70                  75                  80  


Val Thr Thr Gln Lys Thr Pro Thr Lys Phe Gln Val Leu His Ser Trp 
                85                  90                  95      


Gln Asn Glu Lys Gly Lys Asp Phe Val Lys Ser Ile Gln Ser Val Ile 
            100                 105                 110         


Glu Asn Ile Arg Asn Val Asn Ser His Tyr Val His Thr Phe Asp Cys 
        115                 120                 125             


Leu Lys Val Asp Ala Ile Pro Ala Ser Ile Ile Glu Phe Met Lys Gln 
    130                 135                 140                 


Ala Phe Glu Leu Ser Ala Val His Val Phe Leu Leu Glu Asn Ser Lys 
145                 150                 155                 160 


Ser Tyr Ser Glu Tyr Val Glu Asn Asp Arg Leu Lys Lys Asn Phe Cys 
                165                 170                 175     


Thr Phe Leu Phe Asp Lys Phe Tyr Thr Phe Glu Lys Lys Ala Asn Lys 
            180                 185                 190         


Val Asn Asp Lys Glu Lys Glu Glu Ser Glu Arg Lys Tyr Leu Glu Ala 
        195                 200                 205             


Arg Glu Glu Phe Arg Arg Leu Asp Lys Arg Asp Ala Leu Asp Val Leu 
    210                 215                 220                 


Leu Phe Val Asp Val Lys Glu Asn Phe Val Trp Lys Val Gly Asp Thr 
225                 230                 235                 240 


His Glu Val Phe Thr Thr Thr Lys Gly Arg Tyr Leu Ser Tyr Asn Ala 
                245                 250                 255     


Cys Leu Phe Leu Leu Ser Leu Phe Leu Tyr Lys Asn Glu Ala Thr Gln 
            260                 265                 270         


Met Ile Ser Lys Ile Lys Gly Phe Lys Arg Asn Lys Thr Lys Glu Glu 
        275                 280                 285             


Asn Ser Lys Arg Asp Ile Phe Thr Phe Leu Ala Lys Lys Phe Ser Ser 
    290                 295                 300                 


Gln Asp Ile Asp Ser Glu Glu Asn His Leu Val Lys Phe Arg Asp Leu 
305                 310                 315                 320 


Val Gln Tyr Leu Asn Lys Tyr Pro Val Asp Trp Lys Ser Ser Leu Glu 
                325                 330                 335     


Asn Glu Asp Glu Cys Thr Glu Lys Val Asp Ala Leu Lys Ser Ala Ile 
            340                 345                 350         


Ile Asp Lys Glu Ile Thr Arg Leu Phe Pro Asp Tyr Ala Lys Ile Pro 
        355                 360                 365             


Arg Phe Val Asp Phe Ala Arg Arg Glu Leu Trp Gly Lys Asp Ile Pro 
    370                 375                 380                 


Asp Asp Phe Ser Asp Glu Glu Lys Asn Glu Phe Gly Tyr Glu Ile Asp 
385                 390                 395                 400 


Thr Ser Ile Glu Leu Lys Asp Ala Glu Lys Lys Leu Ala Glu Phe Glu 
                405                 410                 415     


Ala Met Ser Asp Tyr Lys Lys Arg Glu Asn Gly Ile Arg Glu Gln Asn 
            420                 425                 430         


Arg Ala Ile Lys Lys Ile Met Asp Ala Gly Arg Asn Glu His Arg Gly 
        435                 440                 445             


Val Ala Lys Leu Lys Asp Arg Leu Ala Arg Gly Val Phe Phe Gln Ser 
    450                 455                 460                 


Tyr Gly Arg Asn Gln Asp Arg Phe Leu Glu Phe Ala Thr Arg Phe Leu 
465                 470                 475                 480 


Ala Glu Gln Gln Tyr Phe Gly Ala Asp Ala Lys Phe Arg Met Gln Gln 
                485                 490                 495     


Phe Tyr Thr Thr Glu Glu Gln Asn Lys Tyr Leu Ala Glu Gln Lys Asn 
            500                 505                 510         


Val Leu Ser Lys Lys Glu Phe Asp Lys Leu Pro Tyr His Asp Ala Met 
        515                 520                 525             


Leu Val His Phe Asp Thr Tyr Asp Lys His Lys Glu Arg Tyr Pro Ser 
    530                 535                 540                 


Trp Asp Met Pro Tyr Val Val Ala Asp Asn Ala Ile Gln Val Lys Leu 
545                 550                 555                 560 


Thr Phe Ala Pro Asp Asn Val Arg Val Val Ser Ile Gln Arg Ala Leu 
                565                 570                 575     


Met Val Tyr Leu Leu Glu His Ala Leu Gln Leu Pro Glu Glu Lys Met 
            580                 585                 590         


Ala Gly Ala Gly Phe Ala Phe Leu Gln Ala Tyr Cys Gln His His Asp 
        595                 600                 605             


Ser Asp Phe Lys Glu Lys His Ala Gln Leu Gln Asn Gly Glu Ile Pro 
    610                 615                 620                 


Met Asp Glu Lys Ala Asp Phe Lys Lys Leu Leu Pro Lys Arg Leu Leu 
625                 630                 635                 640 


Lys Ala Tyr Phe Pro Gln Gly Glu Lys Thr Thr Glu Pro Ser Ala Leu 
                645                 650                 655     


Gln Gln Leu Leu Asp Arg Ala Glu Ser Ala Glu Met Arg Tyr Lys Ala 
            660                 665                 670         


Leu His Asp Met His Glu Gln Asn Asn Asn Leu Ser Glu Phe Glu Lys 
        675                 680                 685             


Arg Asn Lys Gly Lys Gln Phe Lys Leu Met Phe Val Arg Lys Ala Trp 
    690                 695                 700                 


Asn Leu Met Tyr Phe Arg Lys Leu Tyr Lys Met Arg Val Glu Glu Glu 
705                 710                 715                 720 


Ile Lys Arg Val Gly Asn Ile Asp Lys Ala His His Lys Ser Phe His 
                725                 730                 735     


Ile Thr Arg Asp Glu Phe Asn Asp Phe Cys Arg Tyr Met Phe Ala Phe 
            740                 745                 750         


Asp Glu Val Pro Glu Tyr Lys Ile Leu Leu Val Lys Met Leu Gln Asn 
        755                 760                 765             


Lys Gly Phe Ile Arg His Asn Ser Leu Ala Ile Met Leu Arg Asp Ser 
    770                 775                 780                 


Lys Ser Leu Asp Asp Leu Tyr Gln Ala Thr Lys Pro Leu Phe Lys Lys 
785                 790                 795                 800 


Trp Met Arg Thr Ser Ala Ala Leu Arg Asp Lys Ser Gln Lys Tyr Thr 
                805                 810                 815     


Leu Ser Ser Tyr Gln Gln Ile Phe Asp Lys Ser Pro Leu Tyr Ile Asn 
            820                 825                 830         


Leu Ser His Phe Ile Glu Phe Ile Lys Asn Glu Lys Tyr Ile Gly Leu 
        835                 840                 845             


Asp Asp Thr Gly Thr Arg Ile Ile Tyr Lys Ser Leu Val Asn Lys Lys 
    850                 855                 860                 


Tyr Leu Val Gly Asp Tyr Tyr Ile Asp Ser Phe Arg Gly Lys Lys Asp 
865                 870                 875                 880 


Ser Ala Thr Arg Lys Leu Ile Asn Gln Leu Met Thr Ala Arg Leu Glu 
                885                 890                 895     


Asp Val Met Leu Tyr Glu Ile Ala Thr Arg Tyr Leu Lys His Thr Pro 
            900                 905                 910         


Asp Val Ala Asn Gln Ala Lys Glu His Val Ala Ile Ile Met Thr Arg 
        915                 920                 925             


Glu Val Ser Phe Asp Val Ser Asp Ala His Lys Lys Lys Leu Tyr Arg 
    930                 935                 940                 


Leu Thr Val Pro Phe Asn Lys Leu Glu Lys Tyr Val Glu Leu Met Lys 
945                 950                 955                 960 


His Lys Glu Asp Gln Asp Glu Glu Tyr Lys Ser Ser Tyr Leu Ala Asn 
                965                 970                 975     


Ile Asn Thr Tyr Ile Glu Glu Ala Asn Thr His Lys Asp Met Lys Ala 
            980                 985                 990         


Val Tyr Glu Ala Phe Cys Lys Asp  Ser Pro Ala Arg Ile  Leu Ser Phe 
        995                 1000                 1005             


Asp Gly  Leu His Lys Ile Asp  Cys His Ile Val Ser  Ser Ser Val 
    1010                 1015                 1020             


Lys Phe  Thr Arg Val Ala Met  Glu Leu Glu Ala Tyr  Leu Ile Glu 
    1025                 1030                 1035             


Lys His  Lys Cys Ser Ile Lys  Lys Asp Asn Arg Ile  Ser Thr Gly 
    1040                 1045                 1050             


Glu Val  Pro Gly Met Asp Ala  Tyr Met Gly Ala Lys  Asn Lys Asn 
    1055                 1060                 1065             


Gly Glu  Tyr Met Leu Arg Asn  Lys Ala Phe His Phe  Ala Leu Pro 
    1070                 1075                 1080             


Asp Leu  Pro Tyr Asp Thr Val  Leu Lys Gln Gln Glu  Ala Thr Phe 
    1085                 1090                 1095             


Val Thr  Asn Glu Val Lys Pro  Arg Asn Pro Ala Ser  Tyr Lys Ser 
    1100                 1105                 1110             


Leu Asp  Arg Lys Gln Lys Arg  Val Cys Glu Leu Leu  Leu Lys Thr 
    1115                 1120                 1125             


Met His  Ser Asn Leu Phe Asp  Arg Lys Arg Tyr Lys  Asp Asp Ser 
    1130                 1135                 1140             


Thr Met  Met Asn Glu Glu Ala  Glu Lys Ser Tyr Phe  Asn Gln Val 
    1145                 1150                 1155             


Ile Arg  Gly Ser Ser Ala Tyr  
    1160                 1165 


<210>  2326
<211>  1196
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2326

Met Lys Thr Ser Lys Glu Phe Glu Asn Tyr Asn Ser Arg Asn Ser Phe 
1               5                   10                  15      


Lys Lys Ile Phe Asp Phe Lys Gly Glu Ile Ala Pro Ile Ala Glu Lys 
            20                  25                  30          


Ala Asn Arg Asn Leu Glu Leu Lys Thr Lys Asn Glu Thr Asn Leu Val 
        35                  40                  45              


Gln Arg Val His Tyr Phe Ala Ile Gly His Thr Phe Lys Tyr Ile Asp 
    50                  55                  60                  


Thr Glu Thr Leu Phe Glu Trp Val Val Asp Glu Glu Thr Gln Met Lys 
65                  70                  75                  80  


Gln Pro Thr Lys Phe Leu Ser Leu Gln Ser Phe Asp Asp Ser Phe Cys 
                85                  90                  95      


Asp Glu Leu Gln Lys Ile Thr Val Val Gly Thr Asn Asn Glu Tyr Asn 
            100                 105                 110         


Gly Leu Ile Pro Ala Ile Arg Asn Ile Asn Ser His Tyr Ile His Ser 
        115                 120                 125             


Phe Glu Lys Ile Arg Ile Asp Ser Leu Ser Pro Val Met Val Lys Phe 
    130                 135                 140                 


Leu Lys Glu Ser Phe Glu Leu Ser Val Ile Gln Ile Tyr Ile Lys Glu 
145                 150                 155                 160 


Glu Asn Glu Leu Lys Arg Ser Lys Asn Glu Arg Leu Ala Ser Thr Lys 
                165                 170                 175     


Glu Ile Ile Glu Gln Asn Gly Phe Gly Lys Arg Leu Val Gln Phe Leu 
            180                 185                 190         


Cys Asp Lys Phe Tyr Pro Val Gly Asn Lys Thr Thr Tyr Pro Glu Asp 
        195                 200                 205             


Tyr Leu Glu Tyr Arg Lys Gln Phe Arg Asn Leu Ser Lys Asp Glu Ala 
    210                 215                 220                 


Ile Asp Ser Leu Leu Phe Val Glu Val Glu Thr Ala Phe Asp Trp Leu 
225                 230                 235                 240 


Leu Phe Glu Thr Tyr Pro Ala Phe Asn Ile Ala Val Gly Lys Tyr Leu 
                245                 250                 255     


Ser Phe Tyr Ser Cys Leu Phe Leu Leu Ser Met Phe Leu Tyr Lys Ser 
            260                 265                 270         


Glu Ala Asn Gln Leu Ile Ser Lys Ile Lys Gln Phe Lys Arg Asn Lys 
        275                 280                 285             


Ile Gln Glu Glu Lys Ser Lys Arg Glu Ile Phe Thr Phe Phe Ser Lys 
    290                 295                 300                 


Arg Phe Ser Ser Gln Asp Ile Asp Ser Glu Glu Asn His Leu Val Lys 
305                 310                 315                 320 


Phe Arg Asp Leu Ile Gln Tyr Leu Asn Arg Tyr Pro Val Ala Trp Asn 
                325                 330                 335     


Lys Asp Ile Glu Leu Glu Ser Gln His Pro Val Met Thr Asp Arg Leu 
            340                 345                 350         


Lys Ala Lys Ile Ile Glu Met Glu Ile Asp Ser Ser Phe Pro Ile Tyr 
        355                 360                 365             


Ala Glu Asn Asn Arg Phe His Val Phe Ala Lys Tyr Gln Ile Trp Gly 
    370                 375                 380                 


Lys Lys Tyr Phe Gly Lys Lys Ile Glu Lys Glu Tyr Ile Glu Gln Ser 
385                 390                 395                 400 


Phe Asn Gly Asn Glu Val Glu Glu Phe Ser Tyr Glu Ile Asn Thr Ser 
                405                 410                 415     


Pro Glu Leu Lys Gly Phe Tyr Leu Lys Leu Ala Asp Leu Lys Ser Lys 
            420                 425                 430         


Pro Gly Leu Tyr Glu Lys His Lys Ala Glu Ile Lys Arg Thr Glu Thr 
        435                 440                 445             


Ser Ile Lys Glu Leu Ile Glu Gln Asn Val Pro Asn Pro Ile Thr Glu 
    450                 455                 460                 


Lys Leu Lys Thr Arg Ile Glu Lys Asn Leu Leu Phe Val Ser Tyr Gly 
465                 470                 475                 480 


Arg Asn Gln Asp Arg Phe Met Asp Phe Ala Thr Arg Tyr Leu Ala Glu 
                485                 490                 495     


Thr Asn Tyr Phe Gly Asn Asp Ala Arg Phe Lys Met Tyr Gln Phe Tyr 
            500                 505                 510         


Thr Thr Thr Glu Gln Asn Lys Glu Tyr Glu Asn Leu Lys Glu Val Lys 
        515                 520                 525             


Ser Lys Lys Glu Ile Asp Arg Leu Lys Phe His His Gly Arg Pro Ile 
    530                 535                 540                 


His Phe Ser Thr Tyr Ser Asn His His Lys Arg Tyr Glu Ser Trp Asp 
545                 550                 555                 560 


Thr Pro Phe Val Phe Glu Asn Asn Ala Ile Gln Val Lys Met Thr Leu 
                565                 570                 575     


Asp His Gly Ile Glu Lys Thr Val Ser Ile Gln Arg Ser Leu Met Val 
            580                 585                 590         


Tyr Leu Leu Glu Asp Ala Leu Phe Lys Ala Asp Lys Ser Met Val Asp 
        595                 600                 605             


Ser Ala Gly Lys His Leu Ile Ser Glu Tyr Phe Thr His Gln Gln Gln 
    610                 615                 620                 


Asp Phe Asn Tyr Ser Arg Leu Val Leu Glu Gln Asn Glu Ser Ile Asn 
625                 630                 635                 640 


Thr Glu Gln Lys Asn Lys Phe Lys Lys Ile Leu Pro Lys Arg Leu Leu 
                645                 650                 655     


Asn His Tyr Leu Pro Ala Ile Gln Asn Asn Thr Pro Ala Phe Ser Thr 
            660                 665                 670         


Leu Gln Leu Ile Leu Glu Lys Ala Lys Leu Ala Glu Glu Arg Tyr Lys 
        675                 680                 685             


Lys Leu Thr Glu Lys Val Lys Thr Glu Gly Asn Tyr Asp Asp Phe Ile 
    690                 695                 700                 


Lys Arg Asn Lys Gly Lys Gln Phe Lys Leu Gln Phe Ile Arg Lys Ala 
705                 710                 715                 720 


Trp His Leu Met Tyr Phe Lys Glu Ser Tyr Lys Gln Gln Ala Ser Phe 
                725                 730                 735     


Ser Gly His His Lys Arg Phe His Ile Glu Arg Asp Glu Phe Asn Asp 
            740                 745                 750         


Phe Ser Arg Phe Met Phe Ala Phe Asp Glu Val Pro Ala Tyr Lys Asp 
        755                 760                 765             


Tyr Leu Lys Gln Leu Leu Asp Lys Lys Gly Phe Phe Glu Asn Gln Gln 
    770                 775                 780                 


Phe Lys Ala Leu Phe Glu Asn Gly Thr Ser Leu Asp Asn Leu Tyr Val 
785                 790                 795                 800 


Lys Thr Lys Gln Ala Tyr Glu Lys Trp Leu Ile Gly Gln Asn Asn Arg 
                805                 810                 815     


Glu Leu Glu Ala Thr Lys Tyr Thr Leu Gln Ser Tyr Glu Gln Phe Phe 
            820                 825                 830         


Ala Asp Asp Met Phe Tyr Ile Asn Gln Ser His Phe Ile Ser Phe Leu 
        835                 840                 845             


Glu Ser Lys Ser Leu Leu Ser Arg Asp Glu Gln Gly Gln Met Arg Phe 
    850                 855                 860                 


Asn Ala Leu Ala Asn Cys Ala Phe Leu Val Ser Glu Phe Tyr Tyr Thr 
865                 870                 875                 880 


Asp Lys Leu Asp Lys Thr Glu Tyr Lys Thr Asn Arg Lys Leu Phe Asn 
                885                 890                 895     


Gln Leu Arg Ser Val Arg Leu Glu Asp Ala Leu Leu Tyr Glu Met Ala 
            900                 905                 910         


Met Cys Tyr Leu Lys Ile Asp Gln Gln Val Val Gln Lys Ala Lys Ala 
        915                 920                 925             


His Val Ile Glu Ile Leu Thr Gln Asn Val Gln Phe Asp Ile Cys Asn 
    930                 935                 940                 


Ser Gln Asp Lys Leu Val Tyr His Leu Val Ile Pro Phe Asn Lys Ile 
945                 950                 955                 960 


Asp Ala Tyr Val Glu Leu Leu Asn Arg Lys Glu Thr Asp Glu Thr Ile 
                965                 970                 975     


Ser Ser Gly Ser Ser Phe Ile Thr Asn Val Asp Lys Tyr Ile Glu Met 
            980                 985                 990         


Ile Trp Asn Glu Ile Pro Trp Lys  Glu Lys Asn Glu Asn  Ala Lys Lys 
        995                 1000                 1005             


Ile Thr  His Ala Ala Met Tyr  Pro Ile Gly Glu Lys  Tyr Ser Arg 
    1010                 1015                 1020             


Gln Lys  Thr Ile Thr Tyr Asp  Asp Leu Gln Lys Ile  Tyr Gln His 
    1025                 1030                 1035             


Leu Leu  Ser Ser Ser Asn Lys  Leu Thr Asn Val Ser  Met Gln Ile 
    1040                 1045                 1050             


Glu Arg  Tyr Tyr Leu Cys Lys  Pro Asp Gly Gln Gly  His Val Val 
    1055                 1060                 1065             


Phe Asn  Gly Glu Thr Asp Arg  Lys Thr Gly Cys Tyr  Leu Ile Arg 
    1070                 1075                 1080             


Phe Glu  Lys Thr Gly Val Pro  Lys Thr Tyr Phe Gly  Val Gly Glu 
    1085                 1090                 1095             


Leu Asn  Ile Arg Asn Lys Ala  Phe His Phe Leu Ile  Thr Pro Ser 
    1100                 1105                 1110             


Lys Ser  Tyr Glu Lys Trp Leu  Met Asp Val Glu Arg  Glu Phe Ile 
    1115                 1120                 1125             


Leu Lys  Glu Val Lys Pro Asn  Asn Pro Lys Ala Tyr  Thr Asp Leu 
    1130                 1135                 1140             


Asn Arg  Ser Val Lys Leu Val  Cys Asp Ile Leu Leu  Asn Thr Leu 
    1145                 1150                 1155             


His Asn  Asn Tyr Phe Lys Leu  Thr Asp Ser Asp Lys  Gly Ile Pro 
    1160                 1165                 1170             


Lys Glu  Glu Gln Gly Lys Gln  Lys Gln Lys Asn Ala  Gln Ile Thr 
    1175                 1180                 1185             


Tyr Phe  Thr Lys His Ile Leu  Tyr 
    1190                 1195     


<210>  2327
<211>  1165
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2327

Met Thr Pro Ala Asn Pro Lys Ile Asn Glu Ile Leu Arg Lys His Asn 
1               5                   10                  15      


Cys Glu Gln Ser Phe Asn Lys Ile Ser Gln Phe Lys Gly Glu Ile Ala 
            20                  25                  30          


Pro Ile Ala Glu Lys Ser Ala Arg Asn Leu Lys Gln Lys Leu Lys Asn 
        35                  40                  45              


Pro Val Asn Gln Glu Gln Arg Leu His His Phe Thr Ile Gly His Lys 
    50                  55                  60                  


Phe Lys Leu Leu Asp Lys Glu His Ile Phe Gln Tyr Lys Val Asp Glu 
65                  70                  75                  80  


Val Thr Thr Gln Lys Thr Pro Thr Lys Phe Gln Val Leu His Ser Trp 
                85                  90                  95      


Gln Asn Glu Lys Gly Lys Asp Phe Val Lys Ser Ile Gln Ser Val Ile 
            100                 105                 110         


Glu Asn Ile Arg Asn Val Asn Ser His Tyr Val His Thr Phe Asp Cys 
        115                 120                 125             


Leu Lys Val Asp Ala Ile Pro Ala Ser Ile Ile Glu Phe Met Lys Gln 
    130                 135                 140                 


Ala Phe Glu Leu Ser Ala Val His Val Phe Leu Leu Glu Asn Ser Lys 
145                 150                 155                 160 


Ser Tyr Ser Glu Tyr Val Glu Asn Asp Arg Leu Lys Lys Asn Phe Cys 
                165                 170                 175     


Thr Phe Leu Phe Asp Lys Phe Tyr Thr Phe Glu Lys Lys Ala Asn Lys 
            180                 185                 190         


Val Asn Asp Lys Glu Lys Glu Glu Ser Glu Arg Lys Tyr Leu Glu Ala 
        195                 200                 205             


Arg Glu Glu Phe Arg Arg Leu Asp Lys Arg Asp Ala Leu Asp Val Leu 
    210                 215                 220                 


Leu Phe Val Asp Val Lys Glu Asn Phe Val Trp Lys Val Gly Asp Thr 
225                 230                 235                 240 


His Glu Val Phe Thr Thr Thr Lys Gly Arg Tyr Leu Ser Tyr Asn Ala 
                245                 250                 255     


Cys Leu Phe Leu Leu Ser Leu Phe Leu Tyr Lys Asn Glu Ala Thr Gln 
            260                 265                 270         


Met Ile Ser Lys Ile Lys Gly Phe Lys Arg Asn Lys Thr Lys Glu Glu 
        275                 280                 285             


Asn Ser Lys Arg Asp Ile Phe Thr Phe Leu Ala Lys Lys Phe Ser Ser 
    290                 295                 300                 


Gln Asp Ile Asp Ser Glu Glu Asn His Leu Val Lys Phe Arg Asp Leu 
305                 310                 315                 320 


Val Gln Tyr Leu Asn Lys Tyr Pro Val Asp Trp Lys Ser Ser Leu Glu 
                325                 330                 335     


Asn Glu Asp Glu Cys Thr Glu Lys Val Asp Ala Leu Lys Ser Ala Ile 
            340                 345                 350         


Ile Asp Lys Glu Ile Thr Arg Leu Phe Pro Asp Tyr Ala Lys Ile Pro 
        355                 360                 365             


Arg Phe Val Asp Phe Ala Arg Arg Glu Leu Trp Gly Lys Asp Ile Pro 
    370                 375                 380                 


Asp Asp Phe Ser Asp Glu Glu Lys Asn Glu Phe Gly Tyr Glu Ile Asp 
385                 390                 395                 400 


Thr Ser Ile Glu Leu Lys Asp Ala Glu Lys Lys Leu Ala Glu Phe Glu 
                405                 410                 415     


Ala Met Ser Asp Tyr Lys Lys Arg Glu Asn Gly Ile Arg Glu Gln Asn 
            420                 425                 430         


Arg Ala Ile Lys Lys Ile Met Asp Ala Gly Arg Asn Glu His Arg Gly 
        435                 440                 445             


Val Ala Lys Leu Lys Asp Arg Leu Ala Arg Gly Val Phe Phe Gln Ser 
    450                 455                 460                 


Tyr Gly Arg Asn Gln Asp Arg Phe Leu Glu Phe Ala Thr Arg Phe Leu 
465                 470                 475                 480 


Ala Glu Gln Gln Tyr Phe Gly Ala Asp Ala Lys Phe Arg Met Gln Gln 
                485                 490                 495     


Phe Tyr Thr Thr Glu Glu Gln Asn Lys Tyr Leu Ala Glu Gln Lys Asn 
            500                 505                 510         


Val Leu Ser Lys Lys Glu Phe Asp Lys Leu Pro Tyr His Asp Ala Met 
        515                 520                 525             


Leu Val His Phe Asp Thr Tyr Asp Lys His Lys Glu Arg Tyr Pro Ser 
    530                 535                 540                 


Trp Asp Met Pro Tyr Val Val Ala Asp Asn Ala Ile Gln Val Lys Leu 
545                 550                 555                 560 


Thr Phe Ala Pro Asp Asn Val Arg Val Val Ser Ile Gln Arg Ala Leu 
                565                 570                 575     


Met Val Tyr Leu Leu Glu His Ala Leu Gln Leu Pro Glu Glu Lys Met 
            580                 585                 590         


Ala Gly Ala Gly Phe Ala Phe Leu Gln Ala Tyr Cys Gln His His Asp 
        595                 600                 605             


Ser Asp Phe Lys Glu Lys His Ala Gln Leu Gln Asn Gly Glu Ile Pro 
    610                 615                 620                 


Met Asp Glu Lys Ala Asp Phe Lys Lys Leu Leu Pro Lys Arg Leu Leu 
625                 630                 635                 640 


Lys Ala Tyr Phe Pro Gln Gly Glu Lys Thr Thr Glu Pro Ser Ala Leu 
                645                 650                 655     


Gln Gln Leu Leu Asp Arg Ala Glu Ser Ala Glu Met Arg Tyr Lys Ala 
            660                 665                 670         


Leu His Asp Met His Glu Gln Asn Asn Asn Leu Ser Glu Phe Glu Lys 
        675                 680                 685             


Arg Asn Lys Gly Lys Gln Phe Lys Leu Met Phe Val Arg Lys Ala Trp 
    690                 695                 700                 


Asn Leu Met Tyr Phe Arg Lys Leu Tyr Lys Met Arg Val Glu Glu Glu 
705                 710                 715                 720 


Ile Lys Arg Val Gly Asn Ile Asp Lys Ala His His Lys Ser Phe His 
                725                 730                 735     


Ile Thr Arg Asp Glu Phe Asn Asp Phe Cys Arg Tyr Met Phe Ala Phe 
            740                 745                 750         


Asp Glu Val Pro Glu Tyr Lys Ile Leu Leu Val Lys Met Leu Gln Asn 
        755                 760                 765             


Lys Gly Phe Ile Arg His Asn Ser Leu Ala Ile Met Leu Arg Asp Ser 
    770                 775                 780                 


Lys Ser Leu Asp Asp Leu Tyr Gln Ala Thr Lys Pro Leu Phe Lys Lys 
785                 790                 795                 800 


Trp Met Arg Thr Ser Ala Ala Leu Arg Asp Lys Ser Gln Lys Tyr Thr 
                805                 810                 815     


Leu Ser Ser Tyr Gln Gln Ile Phe Asp Lys Ser Pro Leu Tyr Ile Asn 
            820                 825                 830         


Leu Ser His Phe Ile Glu Phe Ile Lys Asn Glu Lys Tyr Ile Gly Leu 
        835                 840                 845             


Asp Asp Thr Gly Thr Arg Ile Ile Tyr Lys Ser Leu Val Asn Lys Lys 
    850                 855                 860                 


Tyr Leu Val Gly Asp Tyr Tyr Ile Asp Ser Phe Arg Gly Lys Lys Asp 
865                 870                 875                 880 


Ser Ala Thr Arg Lys Leu Ile Asn Gln Leu Met Thr Ala Arg Leu Glu 
                885                 890                 895     


Asp Val Met Leu Tyr Glu Ile Ala Thr Arg Tyr Leu Lys His Thr Pro 
            900                 905                 910         


Asp Val Ala Asn Gln Ala Lys Glu His Val Ala Ile Ile Met Thr Arg 
        915                 920                 925             


Glu Val Ser Phe Asp Val Ser Asp Ala His Lys Lys Lys Leu Tyr Arg 
    930                 935                 940                 


Leu Thr Val Pro Phe Asn Lys Leu Glu Lys Tyr Val Glu Leu Met Lys 
945                 950                 955                 960 


His Lys Glu Asp Gln Asp Glu Glu Tyr Lys Ser Ser Tyr Leu Ala Asn 
                965                 970                 975     


Ile Asn Thr Tyr Ile Glu Glu Ala Asn Thr His Lys Asp Met Lys Ala 
            980                 985                 990         


Val Tyr Glu Ala Phe Cys Lys Asp  Ser Pro Ala Arg Ile  Leu Ser Phe 
        995                 1000                 1005             


Asp Gly  Leu His Lys Ile Asp  Cys His Ile Val Ser  Ser Ser Val 
    1010                 1015                 1020             


Lys Phe  Thr Arg Val Ala Met  Glu Leu Glu Ala Tyr  Leu Ile Glu 
    1025                 1030                 1035             


Lys His  Lys Cys Ser Ile Lys  Lys Asp Asn Arg Ile  Ser Thr Gly 
    1040                 1045                 1050             


Glu Val  Pro Gly Met Asp Ala  Tyr Met Gly Ala Lys  Asn Lys Asn 
    1055                 1060                 1065             


Gly Glu  Tyr Met Leu Arg Asn  Lys Ala Phe His Phe  Ala Leu Pro 
    1070                 1075                 1080             


Asp Leu  Pro Tyr Asp Thr Val  Leu Lys Gln Gln Glu  Ala Thr Phe 
    1085                 1090                 1095             


Val Thr  Asn Glu Val Lys Pro  Arg Asn Pro Ala Ser  Tyr Lys Ser 
    1100                 1105                 1110             


Leu Asp  Arg Lys Gln Lys Arg  Val Cys Glu Leu Leu  Leu Lys Thr 
    1115                 1120                 1125             


Met His  Ser Asn Leu Phe Asp  Arg Lys Arg Tyr Lys  Asp Asp Ser 
    1130                 1135                 1140             


Thr Met  Met Asn Glu Glu Ala  Glu Lys Ser Tyr Phe  Asn Gln Val 
    1145                 1150                 1155             


Ile Arg  Gly Ser Ser Ala Tyr  
    1160                 1165 


<210>  2328
<211>  985
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2328

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Asn Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys Gly Tyr 
                165                 170                 175     


Ala Phe Phe Ile Ser Lys Phe Leu Glu Arg Lys Tyr Ser Tyr Leu Phe 
            180                 185                 190         


Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln Tyr Arg 
        195                 200                 205             


Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro Val Glu 
    210                 215                 220                 


Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu Asp Ile 
225                 230                 235                 240 


Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr Leu Glu 
                245                 250                 255     


Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr Asp Ala 
            260                 265                 270         


Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe Arg Ser 
        275                 280                 285             


Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala Asp Phe 
    290                 295                 300                 


Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His Asn Gly 
305                 310                 315                 320 


Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr Ile Asn 
                325                 330                 335     


Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser Ala Lys 
            340                 345                 350         


Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser Thr Asp 
        355                 360                 365             


Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln Ser Thr 
    370                 375                 380                 


Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val Leu Pro 
385                 390                 395                 400 


Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala Lys Met 
                405                 410                 415     


Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala Met Leu 
            420                 425                 430         


Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His Cys Pro 
        435                 440                 445             


Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser Thr Lys 
    450                 455                 460                 


Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg Val Met 
465                 470                 475                 480 


Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu Arg Ile 
                485                 490                 495     


Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile Leu Lys 
            500                 505                 510         


Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp Leu Gln 
        515                 520                 525             


Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn Phe Gln 
    530                 535                 540                 


Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn Asp Leu 
545                 550                 555                 560 


Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn Pro His 
                565                 570                 575     


Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile Glu Phe 
            580                 585                 590         


Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg Ile Gln 
        595                 600                 605             


Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro Leu Arg 
    610                 615                 620                 


Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu Ala Ile 
625                 630                 635                 640 


Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys Leu Lys 
                645                 650                 655     


Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu Lys Ser 
            660                 665                 670         


Pro Ala Leu Asn Val Ser Tyr Leu Ile His Asn Tyr Phe Arg Ala Tyr 
        675                 680                 685             


Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn Tyr Arg 
    690                 695                 700                 


Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser Tyr Leu 
705                 710                 715                 720 


Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro Ser Lys 
                725                 730                 735     


Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp Arg Leu 
            740                 745                 750         


Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile Ile Arg 
        755                 760                 765             


Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys Glu Tyr 
    770                 775                 780                 


Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu Glu Asn 
785                 790                 795                 800 


Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp Leu Asn 
                805                 810                 815     


Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr Gly Lys 
            820                 825                 830         


Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn Lys Val 
        835                 840                 845             


Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val Lys Ile 
    850                 855                 860                 


Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu Glu Ala 
865                 870                 875                 880 


Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala Met Val 
                885                 890                 895     


Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr Tyr Asp 
            900                 905                 910         


Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln Lys Ile 
        915                 920                 925             


Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His Asp Lys 
    930                 935                 940                 


Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val Tyr Ala 
945                 950                 955                 960 


Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile Lys Leu 
                965                 970                 975     


Glu Asp Leu Ser Asn Asp Ser Ser Ala 
            980                 985 


<210>  2329
<211>  1140
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2329

Met Glu Asn Asp Gln Gln Ile Leu Glu Asn Arg Arg Arg Thr Leu Ala 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Ser Asn His Leu Ala Ala Ser Phe Glu Gln Lys Val 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ala Ser Phe Leu Cys Asn Lys Ser 
    50                  55                  60                  


Ile Lys Lys Ile Asn Trp Asn His Val Tyr Ser Lys Ala Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ala Asp Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Arg Glu Thr Thr Asp Lys Glu Gly Lys Asp Phe Thr Ala Met Asn Glu 
            100                 105                 110         


Thr Leu Lys Leu Val Phe Asp Glu Leu Gln Ala Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Ala Asp Ser Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Val Glu Leu Ala Asp Phe Leu Thr Val Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Ala Asp Asp Asp Tyr 
                165                 170                 175     


Thr Met Val Glu Ser Lys Gln Ile Val Thr Pro Asp Asn Leu Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Val Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Leu Ala Tyr Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asp Leu Gly Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Glu 
            260                 265                 270         


Val Ile Thr Glu Glu Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Glu Glu Glu Arg 
    290                 295                 300                 


Glu Lys Ile Leu Asp Glu Ile Asp Tyr Glu Asp Tyr Ile Glu Ser Leu 
305                 310                 315                 320 


Thr Arg Arg Val Arg His Ser Asn Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Lys Tyr Asn Lys Gln Phe Asp Gly Glu 
        355                 360                 365             


Ala Thr Glu Cys Lys Val Val Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asn Gln Glu Thr Val Glu Leu Lys Ile Asp Ser Ala 
385                 390                 395                 400 


Gln Arg Thr Asn Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Glu Ala Arg Leu Leu 
            420                 425                 430         


Thr Lys Ala Lys Pro Glu Ser Lys Val Ser Tyr Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Lys Ala Glu Glu Met Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Lys Val Asn Asp Ser Gln Leu Met Ser Met Gln Phe Ile Asp Glu 
                485                 490                 495     


Ile Lys Glu Gln Leu Pro Ala Asp Trp Asn Glu Phe Gly Lys Arg Ser 
            500                 505                 510         


Asp Ser Lys Lys Lys Lys Ala Tyr Thr Asn Ala Ala Leu Gln Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Lys Val Leu Ala Asn Tyr Gln Leu 
    530                 535                 540                 


Asn Asp Lys Gln Val Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Ser Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Val Glu Lys His Lys Leu 
            580                 585                 590         


Asp Lys Ser Ala Arg Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Thr Asp Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Phe Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Tyr 
625                 630                 635                 640 


Ala Asp Thr Asp Lys Lys Ala Thr Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Lys Gly Gly His Pro Phe Leu Ala Asn Ile Asn 
            660                 665                 670         


Leu Arg Gln Ile Arg Lys Thr Ser Gln Leu Tyr Glu Leu Tyr Leu Val 
        675                 680                 685             


Glu Lys Ala Asn Lys Gln Val Lys Lys Met Asn Pro Lys Thr Gln Arg 
    690                 695                 700                 


Thr Ser Asn Val Asp Glu Ser Trp Met Met Lys Ser Phe Tyr Ala Lys 
705                 710                 715                 720 


Glu Trp Asn Glu Glu Met Gly Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Val Asn Lys Thr Asn Ile Pro Phe Thr Ile Arg Gln Trp Glu Glu Lys 
            740                 745                 750         


Glu Lys His Asn Leu Gln Ala Trp Leu His Asn Ile Thr Lys Gly Lys 
        755                 760                 765             


Thr Ser Lys Asp Gly Lys Lys Ala Ile Asp Leu Pro Thr Asn Leu Phe 
    770                 775                 780                 


Asp Asp Thr Leu Cys Glu Leu Leu Arg Glu Ala Leu Ile Asn Gln Gly 
785                 790                 795                 800 


Ile Asp Ala Thr Pro Thr Thr Lys Tyr Asn Glu Leu Leu Lys Gln Trp 
                805                 810                 815     


Trp Thr Ala Arg Glu Asp Ser Thr Gln Asp Phe Tyr Leu Ser Glu Arg 
            820                 825                 830         


Gln Tyr Asp Ile Tyr Asp Glu Lys Val Cys Phe Thr Ile Asn Ser Ser 
        835                 840                 845             


Ala His Phe Ala Asp Tyr Tyr Ala Pro Ala Leu Asn Lys Ala Tyr Ser 
    850                 855                 860                 


Arg Leu Arg Ala Glu Arg Asp Val Ala Arg Arg Thr Asp Lys Arg Leu 
865                 870                 875                 880 


Pro Pro Val Glu Arg Lys Asp Val Glu Arg Val Phe Lys Asn Thr Ile 
                885                 890                 895     


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
            900                 905                 910         


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asn Gln Gln Gln Leu Lys 
        915                 920                 925             


Leu Ser Lys Met Asp Ser Leu Leu Asn Glu Thr Lys Arg Ile Glu Gln 
    930                 935                 940                 


Thr Ile Asn Thr Gln Leu Ser Phe Asp His Lys Gly Lys Glu Ile Lys 
945                 950                 955                 960 


Asp Lys Thr Asn Ser Glu Ile Val Lys Thr Ile Val Ala Glu Arg Lys 
                965                 970                 975     


Gln Lys Asn Tyr Thr Glu Met Arg Lys Tyr Val His Asp Arg Arg Leu 
            980                 985                 990         


Pro Glu Leu Phe Glu Tyr Ile Asp  Gly Asn Glu Leu Pro  Leu Asp Val 
        995                 1000                 1005             


Leu Leu  Asn Glu Leu Arg Ala  Tyr Asn Thr Ala Lys  Gln Met Val 
    1010                 1015                 1020             


Phe Asp  Thr Val Phe Ala Leu  Glu Lys Lys Ile Ile  Glu Thr Asp 
    1025                 1030                 1035             


Pro Glu  Gly Leu Lys Gln Leu  Asn Val Gly Lys Asn  Gly Gln Ile 
    1040                 1045                 1050             


Gln Thr  Gly Asn Ile Gln His  Lys Pro Tyr Val Gln  Trp Leu Glu 
    1055                 1060                 1065             


Asn Lys  Gly Leu Ile Thr Asp  His Gln Lys Gln Phe  Ile Asn Met 
    1070                 1075                 1080             


Val Arg  Asn Ser Phe Ser His  Asn Gln Phe Pro Gln  Arg Ser Thr 
    1085                 1090                 1095             


Val Glu  Leu Leu Met Pro Glu  Trp Gln Asn Thr Asp  Ile Ala Leu 
    1100                 1105                 1110             


Gln Ile  Ala Arg Glu Tyr Gln  Gln Leu Ile Val Asp  Ile Ile Glu 
    1115                 1120                 1125             


Lys Ser  Leu His Pro His Lys  Gln His Gln Met Val  
    1130                 1135                 1140 


<210>  2330
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2330

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2331
<211>  1130
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2331

Met Thr His Phe Lys Lys Ile Gly Pro Asp Asp Tyr Tyr Phe Ser Ala 
1               5                   10                  15      


Phe Ala Ser Leu Ala Arg His Asn Ile Tyr Ile Val Leu His Ser Ile 
            20                  25                  30          


Asp Ala Tyr Ile Gly Lys Pro Ser Lys His Asp Asp Asp Ala Lys Ile 
        35                  40                  45              


Asn Asn Phe Asn Cys Leu Asn Tyr Ile Ile Asn Asn Gly Lys Lys Lys 
    50                  55                  60                  


Ser Asp Ile Ile Glu Lys Ile Thr Ser Lys Leu Glu Tyr His Phe Pro 
65                  70                  75                  80  


Phe Leu Glu Leu Leu Leu His Asn Lys Lys Thr Ile Ser Val Asp Lys 
                85                  90                  95      


Lys Lys Lys Val Ile Tyr Gln Thr Ile Glu Thr Ser Lys Tyr Tyr Glu 
            100                 105                 110         


Lys Leu Ile Ala Leu Phe Asp Gln Ile Thr Asp Trp Arg Asp Ile Gly 
        115                 120                 125             


Ala His Ala Glu Asp Ile His Lys Lys Lys Leu Thr Ala Lys Phe Val 
    130                 135                 140                 


Glu Asp Leu Arg Lys Ile Tyr Asp Ala Ser Trp His Lys Thr Lys Glu 
145                 150                 155                 160 


Gly Leu Ser Leu Ser Val Ser Gln Met Asp Gln Leu Val Arg Leu Lys 
                165                 170                 175     


Gly Arg Gln Thr Lys Asn His Asp Lys Leu Gln Val Gln Lys Asp Arg 
            180                 185                 190         


Pro Asn Phe Lys Tyr Gly Leu Ile Asn Asp Ser Asn His Phe Ser Glu 
        195                 200                 205             


Gln Gly Leu Ala Phe Leu Ile Cys Leu Phe Leu Gln Glu Ser Glu Ala 
    210                 215                 220                 


Asn Leu Phe Leu Lys His Val Glu His Val Trp Ser Asn Gln Asp Phe 
225                 230                 235                 240 


Asn Ser Asn Ser Thr Asn Leu Asn Ser Ser Gln Ala Ile Lys Leu Phe 
                245                 250                 255     


Thr Ala Tyr Arg Leu Arg Leu Pro Phe Pro Lys Leu Gln Ser Ser His 
            260                 265                 270         


Asp Ser Gln Ser Leu Phe Leu Asp Met Ile Asn Ser Leu Lys Lys Cys 
        275                 280                 285             


Pro Ser Ile Leu Phe Asn His Ile Ser Asn Leu Asp Lys Lys Lys Phe 
    290                 295                 300                 


Lys Lys Asp Ile Lys Asn Ser Glu Val Asn Phe Gly Ser Glu Glu Leu 
305                 310                 315                 320 


Ile Thr Asn Glu Asn Ile Glu Thr Val His Glu Val Arg Lys Arg Asp 
                325                 330                 335     


Arg Phe Val Ile Gln Ala Leu Glu Tyr Phe Asp Leu Thr Asn Thr Phe 
            340                 345                 350         


Asn Tyr Met Arg Phe His Ile Asp Leu Gly Lys Phe Ile Tyr Lys Thr 
        355                 360                 365             


Tyr Thr Ser Pro Ile Asp Gly Thr Asp Arg Ile Arg Arg Leu Glu Lys 
    370                 375                 380                 


Asn Leu His Ala Phe Asp Lys Ile Gln Glu Val Ile Gly Glu Lys Arg 
385                 390                 395                 400 


Pro Glu Ile Trp Lys Asn Leu Ile Lys Glu Pro Asn Thr Ile Pro Glu 
                405                 410                 415     


Asp Ser Leu Asp Cys Tyr Ile Val Asp Thr Glu Pro His Tyr His Ile 
            420                 425                 430         


Ser Asp His Lys Ile Gly Phe Lys Val Phe Gln Asn Val Leu Pro Ser 
        435                 440                 445             


Phe His Asp Ile Val Lys Ile Gly Glu Asn Asn Phe Lys Phe Ser Glu 
    450                 455                 460                 


Asn Pro Lys Pro Asp Gly Phe Ile Ser Ile Tyr Glu Leu Pro Ala Met 
465                 470                 475                 480 


Val Phe Tyr Glu His Ile Thr Gly Asn His Gly Lys Ser Glu Glu Ile 
                485                 490                 495     


Ile Arg Glu His Ile Lys Gln Arg Arg Lys Ile Ile Thr Glu Val Leu 
            500                 505                 510         


Asn Asp Ser Asn Leu Pro Leu Tyr Lys Thr Ser Ile Asn Leu Lys Leu 
        515                 520                 525             


Phe Thr His Pro Ile Gln Pro Glu Phe Ile Asn Ile His Asn Glu Ile 
    530                 535                 540                 


Ile Lys Arg Lys Arg Ala Ala Glu Ser Tyr Leu Ser Thr Lys Asn Ile 
545                 550                 555                 560 


Asp Tyr Arg Asn Ile Pro Glu Ser Ile Ile Tyr Tyr Ile Ala Asn Ile 
                565                 570                 575     


Asp Glu Ile Pro Glu Asp Ile Arg Ile Tyr Asn Ile Leu Glu Ser Met 
            580                 585                 590         


Lys Leu Asp Ala Lys Glu Lys Leu Asn Asn Leu Lys Asn Arg Ile Glu 
        595                 600                 605             


Asn Pro Gln Lys Lys Gly Lys Arg Gly Ala Lys Ala Leu Leu Asp Gly 
    610                 615                 620                 


Gln Leu Ala Thr Glu Leu Ser Lys Asp Ile Leu Tyr Leu Gln Pro Ser 
625                 630                 635                 640 


Asp Lys Asp Ala Lys Asn Lys Ala Asn Pro Leu Glu Tyr Gln Ile Leu 
                645                 650                 655     


Gln Ala Lys Leu Ser Lys Phe Asn Ile Glu Lys Ser Lys Leu Tyr Glu 
            660                 665                 670         


Trp Phe Lys Glu Ile Lys Leu Ile Ser Ile Glu Glu Thr Leu Asp His 
        675                 680                 685             


Pro Phe Leu Phe Lys Leu Asn Pro Asn Asn Phe Ser Ser Ile Val Ser 
    690                 695                 700                 


Phe Tyr Thr Glu Tyr Phe Lys Trp Lys Val Lys Tyr Leu Glu Tyr Leu 
705                 710                 715                 720 


Ile Lys Asn Asn Ile Thr Pro Gly Phe Val Lys Leu Asn Asn Leu Asn 
                725                 730                 735     


Phe Lys Ala Arg Ile Ser Thr Tyr Ile Ala Lys Lys Asn Tyr Ala Ser 
            740                 745                 750         


Ser Lys Thr Asp Glu Tyr Tyr Leu Val Pro Thr Gln Ile Pro His Gly 
        755                 760                 765             


Phe Phe Thr Pro Tyr Ile Ile Gln Glu Ile Glu Lys Leu Pro Asn Gly 
    770                 775                 780                 


Gln Ala Ile Leu Ser Ser Arg Gly Ser Thr Lys Ser Gly Asp Gln Tyr 
785                 790                 795                 800 


Ile Asn Phe Glu Tyr Ile Val Lys Asn Tyr Phe Ser Leu Tyr Lys Glu 
                805                 810                 815     


Asp Ser Asn Gln Ser Tyr Tyr Gln Phe Lys Arg Asn Tyr Glu Ile Phe 
            820                 825                 830         


Asp Ile Val Asn Asp Thr Arg Thr Ile Ala Gln Lys Asn Asn Pro Leu 
        835                 840                 845             


Pro Ser Lys Asp Tyr Ser Val Glu Glu Met Ile Ile Glu Arg Thr Lys 
    850                 855                 860                 


Val Gln Asn Ile Leu Glu Gln Leu Lys Val Lys Asn Glu Pro Asn Val 
865                 870                 875                 880 


Thr Ala Ser Phe Gly Ile Ser Thr Lys Thr Tyr Glu Lys Leu Lys Ser 
                885                 890                 895     


Leu Tyr Lys His Tyr Asn Glu Asn Glu Lys Asn Ile Arg Ile Gln Lys 
            900                 905                 910         


Thr Lys Asp Met Val Thr Phe Leu Met Cys Glu Arg Leu Phe Pro His 
        915                 920                 925             


Glu Leu Phe Glu Asn Thr Lys Ser Ile Gly Lys Leu Lys Glu Ile Asn 
    930                 935                 940                 


Pro Asp Asn Ser Thr Ser Ile Leu Asn Ser Asn Ile Asn Ile Glu Lys 
945                 950                 955                 960 


Ser Ile Thr Leu Lys Arg Asn Phe Gly Glu Thr Asn Tyr Ser Lys Thr 
                965                 970                 975     


Ile Thr His Thr Cys Lys Leu Lys Asp Ser Gly Val Ile Asn Lys Leu 
            980                 985                 990         


Leu Asn Asp Arg Arg Leu Pro Glu  Leu Leu Leu Tyr Phe  Asn Thr Ser 
        995                 1000                 1005             


Lys Ile  Pro Phe Glu Ile Ile  Ile Lys Glu Leu Leu  Asp Tyr Asn 
    1010                 1015                 1020             


Thr Glu  Arg Ile Asp Phe Phe  Lys Ala Ile Ile Asp  Phe Glu Lys 
    1025                 1030                 1035             


Arg Tyr  Phe Ile Ser Glu Ser  Lys Lys Lys Leu Lys  Thr Leu Glu 
    1040                 1045                 1050             


Ala Asn  Glu Tyr Arg Lys His  Ser Glu Leu Ile Asn  Thr Leu Ile 
    1055                 1060                 1065             


Gly Thr  Glu Arg Ile Arg Asp  Glu Ala Glu Ala Glu  Gly Leu Trp 
    1070                 1075                 1080             


Ser Ala  Arg Asn Ala Phe Tyr  His Asn Gln Tyr Pro  Lys Lys Glu 
    1085                 1090                 1095             


Leu Phe  His Glu Tyr Val Thr  Asn Ile Ile Asn Lys  Ser Thr Lys 
    1100                 1105                 1110             


Ile Ala  Lys Pro Ile Ile Lys  Lys Ser Lys Asn Lys  Tyr Asp Asn 
    1115                 1120                 1125             


Leu Pro  
    1130 


<210>  2332
<211>  1146
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2332

Met Glu Ser Ile Ile Gly Leu Gly Leu Ser Phe Asn Pro Tyr Lys Thr 
1               5                   10                  15      


Ala Asp Lys His Tyr Phe Gly Ser Phe Leu Asn Leu Ala Asp Asn Asn 
            20                  25                  30          


Leu Lys Ala Val Phe Ala Glu Phe Lys Glu Arg Ile Ser Asp Lys Ser 
        35                  40                  45              


Lys Asp Glu Asp Ile Ser Asn Leu Ile Glu Lys His Phe Ile Asp Asn 
    50                  55                  60                  


Met Ser Ile Val Asp Tyr Glu Lys Asn Ile Ser Ile Leu Asn Gly Tyr 
65                  70                  75                  80  


Leu Pro Ile Ile Asp Phe Leu Asp Asp Glu Leu Glu Asn Asn Leu Asn 
                85                  90                  95      


Thr Arg Val Lys Asn Phe Lys Lys Ser Phe Ile Ile Leu Ala Glu Ala 
            100                 105                 110         


Leu Glu Thr Leu Arg Asn Tyr Tyr Thr His Phe Tyr His Asp Pro Ile 
        115                 120                 125             


Thr Phe Gly Asp Asn Lys Glu Pro Leu Leu Glu Leu Leu Asp Glu Val 
    130                 135                 140                 


Leu Leu Lys Thr Ile Leu Asp Val Lys Lys Lys Tyr Leu Lys Thr Asp 
145                 150                 155                 160 


Lys Thr Lys Glu Ile Leu Lys Asp Ser Leu Arg Glu Glu Met Asp Leu 
                165                 170                 175     


Leu Val Ile Arg Lys Thr Asp Glu Leu Arg Glu Lys Lys Lys Thr Asn 
            180                 185                 190         


Pro Lys Phe Lys Phe Ser Thr Asp Pro Thr Gln Ile Arg Asn Ser Ile 
        195                 200                 205             


Phe Asn Asp Ala Phe Gln Gly Leu Leu Tyr Glu Asp Lys Glu Asn Asn 
    210                 215                 220                 


Gly Lys Thr Gln Val Ser His Arg Ala Lys Thr Lys Leu Asn Pro Lys 
225                 230                 235                 240 


Asp Ile His Lys Gln Glu Glu Arg Asp Phe Glu Ile Pro Leu Ser Thr 
                245                 250                 255     


Ser Gly Ile Val Phe Leu Met Ser Leu Phe Leu Ser Lys Lys Glu Ile 
            260                 265                 270         


Glu Asp Phe Lys Ser Asn Ile Lys Gly Phe Lys Gly Lys Val Val Lys 
        275                 280                 285             


Asp Glu Asn His Asn Ser Leu Lys Tyr Met Ala Thr His Arg Val Tyr 
    290                 295                 300                 


Ser Ile Leu Ala Phe Lys Gly Leu Lys Tyr Arg Ile Lys Thr Asp Thr 
305                 310                 315                 320 


Phe Ser Lys Val Thr Leu Met Met Gln Met Ile Asp Glu Leu Ser Lys 
                325                 330                 335     


Val Pro Asp Cys Val Tyr Gln Asn Leu Ser Glu Thr Lys Gln Lys Asp 
            340                 345                 350         


Phe Ile Glu Asp Trp Asn Glu Tyr Leu Lys Asp Asn Glu Glu Asn Thr 
        355                 360                 365             


Glu Asn Leu Glu Asn Ser Arg Val Val His Pro Leu Ile Arg Lys Arg 
    370                 375                 380                 


Tyr Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe 
385                 390                 395                 400 


Ala Asn Phe Lys Thr Leu Lys Phe Gln Val Phe Met Gly Tyr Tyr Ile 
                405                 410                 415     


His Asp Gln Arg Thr Lys Thr Ile Gly Thr Thr Asn Ile Thr Thr Glu 
            420                 425                 430         


Arg Thr Val Lys Glu Lys Ile Asn Val Phe Gly Lys Leu Ser Lys Met 
        435                 440                 445             


Asp Asn Leu Lys Lys His Phe Phe Ser Gln Leu Ser Asp Glu Glu Asn 
    450                 455                 460                 


Thr Asp Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Phe Leu Thr Gln 
465                 470                 475                 480 


Ala Asp Asn Ser Pro Ala Asn Asn Ile Pro Ile Tyr Leu Glu Leu Lys 
                485                 490                 495     


Asn Gln Gln Ile Ile Lys Glu Lys Asp Asp Ile Lys Ala Glu Val Asn 
            500                 505                 510         


Asn Ser Gln Asn Arg Asn Pro Asn Lys Pro Ser Lys Arg Asp Leu Leu 
        515                 520                 525             


Asn Lys Ile Ser Asn Thr Asn Glu Asp Phe Tyr Gln Gly Asp Pro Thr 
    530                 535                 540                 


Ala Ile Leu Ser Leu Asn Glu Ile Pro Ala Leu Leu His Leu Phe Leu 
545                 550                 555                 560 


Val Gln Pro Asp Asn Lys Thr Gly Gln Gln Ile Glu Asn Ile Ile Arg 
                565                 570                 575     


Ile Lys Ile Glu Lys Gln Phe Asn Ser Ile Lys Asn Pro Ser Lys Asp 
            580                 585                 590         


Asp Lys Gly Val Pro Lys Ser Leu Phe Ala Asp Thr Asn Val Arg Val 
        595                 600                 605             


Asn Ala Ile Lys Leu Lys Lys Asp Leu Gly Glu Glu Leu Asp Met Leu 
    610                 615                 620                 


Asn Lys Lys Gln Ile Val Phe Lys Glu Asn Gln Lys Ala Ser Ser Asn 
625                 630                 635                 640 


Tyr Asp Glu Leu Leu Lys Lys His Gln Phe Thr Pro Lys Asn Lys Arg 
                645                 650                 655     


Pro Ala Leu Arg Lys Tyr Val Phe Tyr Asn Ser Glu Lys Gly Glu Glu 
            660                 665                 670         


Ala Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Lys Gly Phe 
        675                 680                 685             


Lys Thr Lys Trp Lys Gly Tyr Gln His Ser Glu Leu Gln Arg Lys Leu 
    690                 695                 700                 


Ala Phe Tyr Asp Arg His Thr Lys Gln Asp Ile Lys Glu Leu Leu Ser 
705                 710                 715                 720 


Gly Cys Glu Phe Asp His Phe Leu Leu Asp Ile Asn Ala Cys Phe Lys 
                725                 730                 735     


Glu Asp Asp Phe Glu Asp Phe Phe Ser Lys Tyr Leu Lys Asn Arg Ile 
            740                 745                 750         


Glu Thr Leu Asn Ile Ile Leu Lys Gln Leu His Asp Phe Lys Asn Glu 
        755                 760                 765             


Pro Thr Pro Leu Lys Gly Val Phe Lys Asn Cys Leu Lys Phe Leu Lys 
    770                 775                 780                 


Gln Lys Asn Tyr Val Thr Glu Asn Pro Glu Ile Ile Lys Lys Arg Ile 
785                 790                 795                 800 


Leu Ala Lys Pro Ala Phe Leu Pro Arg Gly Ile Phe Asp Glu Arg Pro 
                805                 810                 815     


Thr Met Lys Lys Gly Lys Asn Pro Leu Ile Asp Arg Asp Glu Phe Ala 
            820                 825                 830         


Lys Trp Phe Val Glu Tyr Leu Glu Asn Lys Asp Tyr Gln Lys Phe Tyr 
        835                 840                 845             


Asn Ser Glu Glu Tyr Arg Ile Arg Asp Ala Asp Phe Lys Lys Asn Ala 
    850                 855                 860                 


Val Ile Lys Lys Gln Lys Leu Lys Asp Phe Tyr Thr Leu Gln Met Val 
865                 870                 875                 880 


Asn Tyr Leu Leu Lys Glu Val Phe Gly Lys Asp Glu Met Asn Leu Gln 
                885                 890                 895     


Leu Ser Glu Leu Phe Gln Thr Arg Gln Glu Arg Leu Lys Leu Gln Gly 
            900                 905                 910         


Ile Ala Lys Lys Gln Met Asn Lys Glu Thr Gly Asp Ser Ser Glu Asn 
        915                 920                 925             


Thr Arg Asn Gln Thr Tyr Ile Trp Asn Lys Asp Val Pro Val Ser Phe 
    930                 935                 940                 


Phe Asn Gly Lys Val Thr Ile Asp Lys Val Lys Leu Lys Asn Ile Gly 
945                 950                 955                 960 


Lys Tyr Lys Arg Tyr Glu Arg Asp Glu Arg Val Lys Thr Phe Ile Gly 
                965                 970                 975     


Tyr Glu Val Asp Glu Lys Trp Met Met Tyr Leu Pro His Asn Trp Lys 
            980                 985                 990         


Asp Arg Tyr Ser Val Lys Pro Ile  Asn Val Ile Asp Leu  Gln Ile Gln 
        995                 1000                 1005             


Glu Tyr  Glu Glu Ile Arg Ser  His Glu Leu Leu Lys  Glu Ile Gln 
    1010                 1015                 1020             


Asn Leu  Glu Gln Tyr Ile Tyr  Asp His Thr Thr Asp  Lys Asn Thr 
    1025                 1030                 1035             


Leu Leu  Gln Asp Gly Asn Pro  Asn Phe Lys Met Tyr  Val Leu Asn 
    1040                 1045                 1050             


Gly Leu  Leu Thr Gly Ile Lys  Gln Val Asn Ile Ala  Asp Phe Ile 
    1055                 1060                 1065             


Val Leu  Lys Gln Asn Thr Asn  Phe Asp Lys Ile Asp  Phe Thr Gly 
    1070                 1075                 1080             


Ile Ala  Ser Cys Ser Glu Leu  Glu Lys Lys Thr Ile  Ile Leu Ile 
    1085                 1090                 1095             


Ala Ile  Arg Asn Lys Phe Ala  His Asn Gln Leu Pro  Asn Lys Thr 
    1100                 1105                 1110             


Ile Tyr  Asp Leu Ala Asn Glu  Phe Leu Lys Lys Glu  Lys Arg Glu 
    1115                 1120                 1125             


Thr Tyr  Ala Asn Tyr Tyr Leu  Lys Val Leu Lys Lys  Met Ile Ser 
    1130                 1135                 1140             


Asp Leu  Ala 
    1145     


<210>  2333
<211>  1220
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2333

Met Ser Thr Arg Tyr Thr Asn Gln Lys Lys Val Glu Glu Asn Ile Asn 
1               5                   10                  15      


Tyr Val Phe Ser Asn Lys Gly Ile Phe Ala Ala Val Ala Glu Lys Thr 
            20                  25                  30          


Leu Thr Asn Tyr Lys Ser Lys Phe Asn Glu Gly Gln Thr Ile Gln Pro 
        35                  40                  45              


Asn Leu His Tyr Phe Ala Val Gly His Thr Phe Lys Asn Ile Asp Thr 
    50                  55                  60                  


Lys Arg Ile Phe Asp Tyr Gln Leu Ser Glu Asp Glu Met Asp Ile Leu 
65                  70                  75                  80  


Pro Thr Lys Tyr Phe Ser Leu Gln Gln Asn Lys Phe Ser Phe Pro Ile 
                85                  90                  95      


Asp Gly Gln Thr Lys Thr Asp Lys Leu Tyr Leu Leu Leu Asp Asn Ile 
            100                 105                 110         


Arg Asn Ile Asn Ala His Phe Ile His Asp Phe Asn Phe Leu Lys Val 
        115                 120                 125             


Asp Asn Ile Asp Glu Asn Ile Ile Cys Phe Leu Ile Asp Ser Phe Glu 
    130                 135                 140                 


Leu Ala Leu Ile Lys Gly Val Phe Ala Lys Lys Tyr Gly Asn Lys Lys 
145                 150                 155                 160 


His Glu Leu Gly Leu Asp Phe Leu Ser Asn Asp Leu Lys Asp Glu Ile 
                165                 170                 175     


Leu Glu Glu Ile Leu Glu Asn Leu Asp Asp Glu Leu Ile Val Phe Met 
            180                 185                 190         


Lys Glu Ile Phe Tyr Gln Thr Leu Tyr Val Val Asp Lys Lys Glu Trp 
        195                 200                 205             


Arg Asn Lys Glu Leu Asn Gln Glu Lys Lys Asp Phe Leu Asp Ser His 
    210                 215                 220                 


Leu Ser Ser Lys Glu Asp Trp Ile Asn Trp Ile Leu Phe Asn Cys Val 
225                 230                 235                 240 


Glu Glu Asp Ile Asp Trp Phe Leu Asn Asn Tyr Gly Asp Ser Asp Pro 
                245                 250                 255     


His Pro Asp Ser Lys Asn His Lys His Lys Val Leu Thr Ile Glu Lys 
            260                 265                 270         


Gly Lys His Leu Ser Phe Glu Gly Ser Leu Phe Met Met Thr Met Phe 
        275                 280                 285             


Leu Tyr Ala Asn Glu Ala Asn Tyr Leu Ile Pro Lys Leu Lys Gly Tyr 
    290                 295                 300                 


Lys Lys Asn Gly Thr Pro Gln Asp Ala Ser Lys Leu Glu Val Phe Arg 
305                 310                 315                 320 


Phe Phe Ala Lys Lys Phe Lys Ser Gln Asp Val Asp Ser Glu His Lys 
                325                 330                 335     


Gln Tyr Val Lys Phe Arg Asp Met Ile Gln Tyr Val Gly Lys Tyr Pro 
            340                 345                 350         


Thr Val Trp Asn Lys His Ile His Leu Asp Asn Tyr Tyr Val Asn Glu 
        355                 360                 365             


Leu Lys Val Ser Ile Leu Glu Asn Glu Ile Thr Gln Leu Phe Glu Gln 
    370                 375                 380                 


Asp Ile Gln Asn Tyr Phe Glu Thr Lys Tyr Gly Leu Gln Lys Phe Ala 
385                 390                 395                 400 


Lys Ala Lys Gly Asp Met His Tyr Ala Phe Val Glu Val Ala Lys Ser 
                405                 410                 415     


Tyr Leu Gln Lys Lys Thr Ile Ser Tyr Lys Gly Lys Tyr Gln Asp Asp 
            420                 425                 430         


Ser Ile Ala Ile Leu Glu Thr Leu Ala Glu Gln Ile Thr Asn Lys Arg 
        435                 440                 445             


Gln Leu Lys Asn Ile Glu Val Lys Leu Leu Arg Phe Ser Asp Thr Asp 
    450                 455                 460                 


Tyr Gln Ser Leu Ser Ser Ile Glu Lys Thr Lys Lys Gln Arg Leu Asp 
465                 470                 475                 480 


Lys Ser Lys Lys Met Phe Leu Asp Lys Ile Lys Glu Ser Lys Lys Thr 
                485                 490                 495     


Ile Asn Lys Thr Thr Glu Lys Phe Ala Lys Arg Val Glu Asp Asn Leu 
            500                 505                 510         


Leu Tyr Ile Ser Asn Gly Arg Asn Ser Asp Arg Phe Met Val Phe Ala 
        515                 520                 525             


Cys Arg Phe Leu Ala Glu Ile Asn Tyr Phe Gly Lys Asp Ala Gln Phe 
    530                 535                 540                 


Lys Met Tyr Glu Asn Tyr Tyr Ser Glu Glu Glu Gln Asn Ala Leu Lys 
545                 550                 555                 560 


Asp Lys Lys Gln Asn Leu Thr Gln Lys Asp Phe Asp Lys Leu His Tyr 
                565                 570                 575     


His Trp Gly Lys Leu Thr His Phe Glu Thr Phe Glu Asn His Val Lys 
            580                 585                 590         


Lys Tyr Pro Asn Trp Asp Met Pro Phe Val Val Gln Asn Asn Ala Ile 
        595                 600                 605             


Tyr Val Lys Ile Pro Gly Ile Asn Phe Ile Lys Asn Thr Ala Phe Cys 
    610                 615                 620                 


Ile Arg Arg Asn Val Ile Asn Tyr Leu Leu Glu His Ala Leu Gly Glu 
625                 630                 635                 640 


Asn Tyr Lys Asp Gln Gln Gly Arg Glu Trp Leu Phe Asp Tyr Tyr Glu 
                645                 650                 655     


Tyr Lys Thr Glu Ala Thr Asp Asn Ala Lys Arg Ile Leu Thr Glu Ser 
            660                 665                 670         


Lys Pro Ile Glu Ala Ser Ser Lys Thr Gln Leu Lys Lys Leu Leu Pro 
        675                 680                 685             


Lys Lys Leu Leu Pro Lys His Ser Pro Leu Glu Thr Glu Asn Lys Glu 
    690                 695                 700                 


Asn Ile Phe Arg Lys Tyr Leu Glu Gln Ala Glu Glu Ser Glu Lys Leu 
705                 710                 715                 720 


Tyr Glu Asn Gln Lys Asp Lys Ala Lys Ala Glu Lys Lys Leu Asp Leu 
                725                 730                 735     


Phe Val Asn Lys Asn Lys Gly Lys Gln Phe Lys Leu Arg Phe Ile Phe 
            740                 745                 750         


Lys Ala Trp Gln Leu Met Tyr Phe Lys Lys Gln Tyr Gln Ile Glu Lys 
        755                 760                 765             


Glu Arg Tyr Ala Glu Leu Glu Lys Leu Asp Gly Ile Pro Lys Asn Tyr 
    770                 775                 780                 


Glu His Glu Phe Gly His His Lys Lys Phe Asn Ile Asn Arg Lys Glu 
785                 790                 795                 800 


Phe Asn Leu Phe Ser Lys Trp Leu Phe Ala Met Asp Glu Val Pro Glu 
                805                 810                 815     


Tyr Lys Asn Ser Leu Lys Glu Leu Leu Asp Asp Lys Asn Phe Phe Val 
            820                 825                 830         


Asn Ser Glu Phe Gln Lys Leu Phe Glu Ser Ser Ser Asn Ile Asn Gln 
        835                 840                 845             


Phe Tyr Glu Ser Thr Lys Ser Lys Phe Lys Asn Trp Leu Asn Asp Gln 
    850                 855                 860                 


Gln Val Gln Asn Ile Arg Lys Thr Ile Gln Pro Glu Asn Tyr Tyr Lys 
865                 870                 875                 880 


Met Met Glu Val Gly Asn Phe His Ile Asn Leu Ser His Phe Ile Ala 
                885                 890                 895     


Phe Gly Val Ser His Asp Phe Ile Glu Lys Ser Gly Lys Asn Ile Leu 
            900                 905                 910         


Arg Pro Ile Thr Ser His Ala Lys Tyr Leu Asn Thr Lys Ile Tyr Asp 
        915                 920                 925             


Ile Asp Leu Glu His Ser Asp Ala Ser Asn Leu Glu Lys Asn Ile Phe 
    930                 935                 940                 


Arg Lys Leu Tyr Lys Ile Arg Leu Glu Asp Cys Leu Leu Tyr Glu Ile 
945                 950                 955                 960 


Ala Leu Arg Tyr Phe Gln Pro Asn Leu Asn Leu Arg Gln Lys Ser Tyr 
                965                 970                 975     


Glu Gln Leu Asn Lys Leu Leu Val Gln Lys Ile Ser Ile Ala Ile Lys 
            980                 985                 990         


Ala Asn Asn Ser Gln Thr Tyr Gln  Val Leu Val Pro Phe  Lys Asp Leu 
        995                 1000                 1005             


Glu Lys  Phe Ala Gln Leu Lys  Ala Ile Asp Asp Asn  Thr Gln Asn 
    1010                 1015                 1020             


Lys Phe  Ser Leu Leu Arg Arg  Leu Pro Glu Tyr Leu  Ser Gln Val 
    1025                 1030                 1035             


Asn Glu  Arg Asn Glu Asn Val  Ser Gly Leu Lys Asp  Met Val Glu 
    1040                 1045                 1050             


Ala Phe  Gly Val Asp Lys Ser  Ile Ser Leu Ala Asp  Met Ser Met 
    1055                 1060                 1065             


Leu Tyr  Asn His Leu Ile Thr  Gln Gln Gly Arg Tyr  Thr Asn Cys 
    1070                 1075                 1080             


Ile Met  Ala Leu Glu Glu Tyr  Phe Ile Trp Lys Glu  Lys Phe Thr 
    1085                 1090                 1095             


Ile Glu  Lys Gln Glu Ser Lys  Lys Phe Lys Asn Arg  Ile Val Val 
    1100                 1105                 1110             


Thr Glu  Ile Pro Val Leu Lys  Asp Tyr Phe Lys Arg  Asp Glu Gln 
    1115                 1120                 1125             


Arg Asn  Asn Ala Phe His Met  Asp Leu Pro Ile Asn  Glu Thr Tyr 
    1130                 1135                 1140             


Lys Ser  Thr Phe Lys Ala Ile  Glu Lys Gln Phe Val  Ala Thr Glu 
    1145                 1150                 1155             


Val Asp  Lys Ala Tyr Thr Lys  Leu Asp Asp Cys Pro  Ser Met Leu 
    1160                 1165                 1170             


Lys Asn  Thr Leu Lys Val Phe  Met Asn Gln Met His  Asp Glu Ile 
    1175                 1180                 1185             


Lys Leu  Gly Tyr Lys Pro Asn  Asp Thr Lys Asp Gly  Ile Lys Gln 
    1190                 1195                 1200             


Lys Arg  Thr Val Ala Glu Asn  Thr Phe Phe Lys Gln  Leu Leu Lys 
    1205                 1210                 1215             


Gly Tyr  
    1220 


<210>  2334
<211>  1038
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2334

Met Asn Gln Ala Pro Tyr Thr Arg Arg Val Lys Thr Leu Lys Thr Asp 
1               5                   10                  15      


Gly Ala Tyr Phe Gly Asn Tyr Leu Asn Met Ala Arg His Asn Ala Tyr 
            20                  25                  30          


Leu Ile Leu Asn Asp Phe Ser Asp Val Phe Glu Glu Leu Lys Ile Glu 
        35                  40                  45              


Glu Ile Asn Glu Glu Asp Leu His Asn Thr Gly Leu Leu Pro Arg Leu 
    50                  55                  60                  


Arg Arg Ser Lys Lys Leu Asp Leu Lys Leu Lys Ala Phe Gln Lys Leu 
65                  70                  75                  80  


Lys His His Phe Pro Phe Leu Gln Cys Ile Asp Asp Pro Glu Lys Ala 
                85                  90                  95      


Leu Gly Val Leu Arg Gln Leu Leu Glu Asn Leu Asn Arg Gln Arg Asn 
            100                 105                 110         


Cys Tyr Thr His Gly Gln His Asp Glu Lys Gly Leu Phe Val Asp Gly 
        115                 120                 125             


Asn Ser Leu Glu Gly Phe Phe Lys Ala Ala Val Lys Lys Val Pro Val 
    130                 135                 140                 


Arg Phe Arg Ser Ile Ile Gly Glu Ala Asp Ile Arg His Met Val Thr 
145                 150                 155                 160 


Tyr Glu Ala Asp Asp Val Arg Lys Glu Lys Gly Gln Leu Thr Ser Phe 
                165                 170                 175     


Tyr Ala Leu Val Asp Pro Arg Gln Ala Leu Thr Glu Lys Gly Leu Ala 
            180                 185                 190         


Phe Phe Thr Cys Leu Phe Leu Glu Arg Arg Tyr Ala Phe Arg Phe Leu 
        195                 200                 205             


Ser Arg Leu Asn Gly Phe Lys Asn Thr Thr Asn Pro Ala Phe Arg Ala 
    210                 215                 220                 


Thr Leu Glu Ala Phe Ala Met Phe Cys Cys Arg Leu Pro Arg Pro Arg 
225                 230                 235                 240 


Leu Glu Ser Gly Glu Leu Met Leu Asp Leu Leu Gly Glu Leu Ser Arg 
                245                 250                 255     


Cys Pro Lys Glu Ile Tyr Gln Val Leu Gly Glu Ala Asp Arg Gln Arg 
            260                 265                 270         


Leu Val Ala Ser Ala Asp Glu Pro Glu Ile Val Leu Asp Ala Asp Asp 
        275                 280                 285             


Asp Pro Glu Leu Pro Glu Thr Ile Met Arg Arg Tyr Gly Asp Arg Phe 
    290                 295                 300                 


Pro Tyr Phe Ala Leu Arg Phe Met Asp Glu Glu Glu Tyr Phe Glu Asn 
305                 310                 315                 320 


Leu Arg Phe His Leu Lys Leu Cys Arg Val Val Lys Lys Glu Tyr Leu 
                325                 330                 335     


Lys Glu Thr Gly Gly Glu Val Arg Glu Arg Lys Leu Val Thr Asp Val 
            340                 345                 350         


Asn Ala Phe Gly Arg Leu Lys Asp Phe Asn Glu Gln Thr Leu Pro Pro 
        355                 360                 365             


Tyr Trp Lys Gly Lys Lys Asp Ile Glu Gln Trp Ser Pro His Tyr Arg 
    370                 375                 380                 


Ile Met Gly Asn Arg Ile Ala Leu Lys Leu Ile Thr Asp Ala Glu Lys 
385                 390                 395                 400 


Asn Arg Glu Ser Val Trp Pro Ala Leu Asn Lys Glu Lys Tyr Lys Thr 
                405                 410                 415     


Met Pro Asp Ala Ile Leu Ser Thr Tyr Glu Leu Gln Asn Leu Leu Val 
            420                 425                 430         


Cys Gln Tyr Leu Tyr Lys Lys Asn Pro Glu Asn Arg Asn Ala Glu Gln 
        435                 440                 445             


Ile Ile Gln Gln Tyr Ile Glu Asn Phe Arg Arg Phe Ile Asn Asp Thr 
    450                 455                 460                 


Arg Glu Gly Lys Val Lys Pro Leu Asp Gly Lys Pro Phe Phe Lys Arg 
465                 470                 475                 480 


Gln Asp Pro Tyr Tyr His Arg Val Leu Asn Gln Leu Ser Asp Cys Ser 
                485                 490                 495     


Gly Gln Leu Gln Val Val Leu Asp Gly Tyr Gly Leu Lys Val Lys Asp 
            500                 505                 510         


Leu Pro Asp Val Met Arg Glu Tyr Leu Leu Gly Tyr Val Pro Ala Ser 
        515                 520                 525             


Tyr Cys Ser Glu Ala Gln Arg Lys Ile Lys Ala Val Leu Gly Glu Val 
    530                 535                 540                 


Arg Gln Arg Ile Lys Ala Ile Glu Lys Gly Arg Ala Pro Arg Val Gly 
545                 550                 555                 560 


Asp Met Ala Gln Phe Leu Ala Arg Asp Val Ile Phe Leu Lys Pro Leu 
                565                 570                 575     


Asn Asp Glu Gly Arg Gly Lys Pro Asn Asn Leu Gln Tyr Asp Leu Leu 
            580                 585                 590         


Gln Gly Met Tyr Ala Phe Phe Gly Lys Glu Lys Tyr Ser Ile Arg Lys 
        595                 600                 605             


Leu His Asn Glu Leu Ala Leu Val Gly Lys Gln His Arg Tyr Thr His 
    610                 615                 620                 


Pro Phe Leu Tyr Arg Ile Arg Leu Asp Glu Cys Asn Gly Ile Leu Asp 
625                 630                 635                 640 


Phe Tyr Gln Arg Tyr Leu Glu Gln Lys Glu Arg Trp Leu Thr Ala Gly 
                645                 650                 655     


Glu Arg Leu Leu Lys Arg Asn Asp Leu Glu Val Phe Arg Glu Arg Tyr 
            660                 665                 670         


Asp Tyr Ser Leu Ser Ile Lys Glu Arg Ser Gly Phe Pro Val Asp Tyr 
        675                 680                 685             


Lys Pro Glu Asn Gln Pro Val Tyr Leu Pro Arg Gly Leu Phe Asn Glu 
    690                 695                 700                 


Ala Val Leu Glu Gly Leu Arg Arg Glu Gly Val Ala Leu Lys Ala Gly 
705                 710                 715                 720 


Asp Asn Leu Val Tyr Ala Met Gly Gln Trp Leu Met Gly Asp Ser Gln 
                725                 730                 735     


Pro Tyr Tyr Leu Met Asn Arg Tyr Tyr Phe Arg Glu Gly Glu Tyr Gln 
            740                 745                 750         


Glu Arg His Asp Tyr Gln Val Cys Leu Ala Ala Met Asp Glu Glu Leu 
        755                 760                 765             


Val His Leu Met Lys Lys Arg Glu Pro Arg Asn Lys Lys Glu Lys Gln 
    770                 775                 780                 


Gln Leu Gln Tyr Ala Ile Gln Asp Val Lys Lys Val Lys Lys Cys Val 
785                 790                 795                 800 


Leu His His Glu Gly Ala Ile Arg Tyr Val Gln Ser Asn Asp Arg Val 
                805                 810                 815     


Met Trp Leu Met Val Gln Val Leu Ala Gln Lys Glu His Asn Ala Ala 
            820                 825                 830         


Tyr Asp Met Gln Arg Phe Ser Leu Arg His Leu Phe Phe Thr Asn Glu 
        835                 840                 845             


Glu Ala Gln Met Ser Asn Asn Leu Leu Lys Lys Glu Ile Pro Met Lys 
    850                 855                 860                 


Ile Asn Ile Glu Asp Lys Leu Ile Ser Asp Thr Leu Pro Leu Arg Arg 
865                 870                 875                 880 


Tyr Gly Glu Phe Arg Ala Ala Met Lys Asp Arg Arg Leu Lys Asn Leu 
                885                 890                 895     


Leu Ser Tyr Tyr Pro Gln Lys Glu Ile Ala His Glu Val Ile Lys Glu 
            900                 905                 910         


Glu Leu Ala Cys Tyr Asp Leu Arg Arg Glu Ala Val Phe Glu Thr Ile 
        915                 920                 925             


Tyr Ser Phe Glu Gln Val Ala Leu Gln Ser Ser Met Gly Glu Val Leu 
    930                 935                 940                 


Gln Ala Lys Ile Asn Ser His Gly Tyr Val Asn His Thr Ile Leu Leu 
945                 950                 955                 960 


Gly Val Leu Phe Glu Gln Gly Ile Ser Leu Ser Gly Gly Trp Thr Lys 
                965                 970                 975     


Glu Glu Val Ile Ile Met Arg Asn Lys Ile Asn His Asn Glu Ile Pro 
            980                 985                 990         


Leu Ala Glu Ser Leu Lys Glu Arg  Val Arg Val Gly Gly  Gly Glu Leu 
        995                 1000                 1005             


Ile Ile  Ala Gln Leu Phe Asp  Ile Val Val Gly Val  Tyr Asn Glu 
    1010                 1015                 1020             


Leu Thr  Glu Lys Thr Lys Ser  Leu Ser Ile Trp Lys  Val Gln Val 
    1025                 1030                 1035             


<210>  2335
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2335

Met Gly Ala Ile Lys Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Gly Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2336
<211>  956
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2336

Met Ala Thr Phe Arg Phe Gln Asn Lys Tyr Val Cys Gly Ala Tyr Tyr 
1               5                   10                  15      


Asn Met Ala Gln Asn Asn Phe Arg Leu Ala Ile Leu His Val Leu Ser 
            20                  25                  30          


Arg Ile Gly Ile Asn Arg Lys Asp Glu Glu Arg Ala Ile Pro Glu Leu 
        35                  40                  45              


Leu Asp Thr Ile Tyr Gly Phe Leu Thr Gly Asp Thr Glu His Phe Asn 
    50                  55                  60                  


Asp Thr Gln Ile Leu Gln Lys Lys Val Leu Thr Leu Arg Tyr Asp Gln 
65                  70                  75                  80  


Gln Val Lys Leu Arg Glu Leu Leu Phe Arg Gln Phe Pro Ile Leu Lys 
                85                  90                  95      


Pro Ile Ile Ala Ser Glu Thr His Lys Ser Leu Gln Glu Gln Lys Glu 
            100                 105                 110         


Lys Leu Ser Glu Met Glu Glu Tyr Ile His Glu Phe Glu Lys Gln Leu 
        115                 120                 125             


Lys Arg Leu Tyr Arg Ser Lys Lys Gly Lys Ala Ser Gln Glu Gln Lys 
    130                 135                 140                 


Glu Ile Asn Glu Gln Ile Lys Tyr Leu Lys Thr Lys Lys Ser Lys Tyr 
145                 150                 155                 160 


Leu Asp Glu Tyr Asp Thr Leu Leu Phe Ser Lys Ser His Asp Ala Asp 
                165                 170                 175     


Leu Gln Leu Cys Leu Lys Ile Leu Lys Thr Met Ala Trp Cys Leu Tyr 
            180                 185                 190         


Asp Leu Arg Asp Phe Tyr Thr His Tyr Asp Pro Tyr Asn Thr Pro Glu 
        195                 200                 205             


Ser Leu Lys Val Lys Tyr Leu Arg Gln Val Thr Val Ala Asn Trp Leu 
    210                 215                 220                 


Ser Gln Val Phe Ala Ala Ser Arg Thr Ile Asp Lys Glu Arg Asn Ser 
225                 230                 235                 240 


Ile Thr Thr Glu Glu Met Asn Phe Leu Asn Glu Ala Lys Lys Gln Gly 
                245                 250                 255     


Asn Asp Lys Lys Trp Arg Glu Asp Pro Asp Tyr Tyr Phe Ala Ile Lys 
            260                 265                 270         


Gly Gln Asn Leu Leu Ser Ser Ser Phe Ile Asp Ala Asp Ser Pro Val 
        275                 280                 285             


Tyr Asn Asp Tyr Leu Asp Glu Leu Tyr Gln Lys Tyr Arg Lys Lys Arg 
    290                 295                 300                 


Leu Ala Trp Met Lys Glu Gln Arg Asp Glu Ala Leu Glu Arg Asp Asp 
305                 310                 315                 320 


Glu Glu Glu Tyr Gly Phe Trp Val Val Glu Met Glu Lys Leu Asp Asn 
                325                 330                 335     


Pro Glu Arg Ile Ala Lys Ile Lys Ser Lys Ile Cys Pro Leu Ala Leu 
            340                 345                 350         


Ser Asp Phe Gly Val Leu Tyr Phe Cys Ala Thr Phe Leu Pro Arg Asn 
        355                 360                 365             


Tyr Thr Leu Leu Met Ala Asp His Ala Glu Val Met Lys Asn Ser Pro 
    370                 375                 380                 


Tyr Ser Met Thr Ala Glu Glu Leu Glu Ala Arg Arg Asn Ala Cys Lys 
385                 390                 395                 400 


Thr Asp Glu Glu Arg Glu Lys Ile Asp Pro Thr Asp Thr Pro Arg Asn 
                405                 410                 415     


Asn Ile Leu Arg Glu Met Leu Cys Ile Tyr Arg Val Arg Leu Pro Lys 
            420                 425                 430         


Gly Lys Arg Leu Asp Lys Lys Asp Thr Lys Gly Leu Leu Thr Leu Asp 
        435                 440                 445             


Ile Leu Asn Glu Leu Arg Lys Cys Pro Lys Glu Val Tyr Glu Gln Leu 
    450                 455                 460                 


Ser Lys Glu Gly Lys Asp Phe Phe Ile Ser Arg Val Ser Ser Ala Ser 
465                 470                 475                 480 


His Asn Ala Pro Asp Ile Val Lys Arg Ile Arg Phe Gly Asp Arg Phe 
                485                 490                 495     


Pro Tyr Leu Ala Leu Arg Ala Ile Asp Glu Ser Asp Val Phe Lys Arg 
            500                 505                 510         


Ile Arg Phe Gln Val Arg Leu Gly Ser Tyr Arg Phe Tyr Phe Tyr Asn 
        515                 520                 525             


Lys Thr Cys Ile Asp Gly Ser Thr Gln Leu Arg Arg Trp Gln Lys Glu 
    530                 535                 540                 


Ile Asn Gly Phe Gly Arg Leu Gln Asp Met Glu Ala Leu Arg Lys Ser 
545                 550                 555                 560 


Leu Trp Lys Asp Leu Leu Gln Lys Lys Glu Tyr Asp Ser Val Gln Leu 
                565                 570                 575     


Glu Asp Lys Ser Gly Tyr Leu Asp Leu Gln Gln Phe Lys Ala Asp Ala 
            580                 585                 590         


Pro Asp Ser Val Pro Tyr Ile Thr Asp Ser Gln Ala Gln Tyr Asn Ile 
        595                 600                 605             


His Asn Asn Arg Ile Gly Leu Ile Trp Asn Gly Asp Glu Cys Arg Leu 
    610                 615                 620                 


Leu Arg Asn Ile Lys Asp Ala Asp Val Leu Arg Glu Tyr Val Tyr Leu 
625                 630                 635                 640 


Pro Asp Leu Lys Asp Asn Asp Gly Asn Pro Lys Lys Ser Gly Lys Asp 
                645                 650                 655     


Ile Glu Gln Pro Ser Pro Leu Cys Ser Leu Ser Thr Tyr Glu Leu Pro 
            660                 665                 670         


Ala Leu Leu Phe Tyr His Phe Leu Tyr Asn Thr Pro Glu Ala Gln Val 
        675                 680                 685             


His Lys Glu Arg Leu Glu Lys Pro Glu Gln Val Ile Ile Lys Lys Tyr 
    690                 695                 700                 


Glu Ala Leu Arg Ala Phe Phe Leu Glu Leu Arg Ser His Pro Glu Gln 
705                 710                 715                 720 


Ile Val Lys Thr Asp Leu Gln Ala Thr Leu Thr Arg Phe Gly Leu Lys 
                725                 730                 735     


Cys Ser Glu Ile Pro Gln Arg Ile Ile Asp Cys Ile Gln Gly Cys Gln 
            740                 745                 750         


Gln Lys Gln Lys Glu Thr Glu Ser Ser Val Thr Tyr Leu Pro Asp Leu 
        755                 760                 765             


Leu Gln Leu Pro Met Glu Asp Ile Arg Gln Lys Val Gln Glu Lys Gly 
    770                 775                 780                 


Met Glu Arg Tyr Lys Asp Leu Pro Ala Lys Phe Arg Lys Gln Ile Ser 
785                 790                 795                 800 


His Glu Gln Ile Val Thr Ser Gly Leu Glu Thr Leu Leu Lys Pro Leu 
                805                 810                 815     


Gly Ile Ser Val Glu Ser Leu Pro Ala Lys Val Met Glu Ala Leu Leu 
            820                 825                 830         


Ser Thr Gln Ile Gln Glu Asp Val Ala Pro Ala Glu Asp Ala Ser Thr 
        835                 840                 845             


Glu Lys Pro Phe Asn Ile Met Phe Val Arg Ser Val Val Tyr Lys Leu 
    850                 855                 860                 


His Glu Arg Leu Gln Asp Val Ser Lys Arg His Gln Ser Phe Val Glu 
865                 870                 875                 880 


Ser Ile His Arg Val Gly Ser Lys Asp Asn Lys Phe Ala Lys His Gly 
                885                 890                 895     


Tyr Met Asp Val Arg His Gly Lys Leu Ala Glu Tyr Leu Ala Gly Ser 
            900                 905                 910         


Phe Leu Lys Trp Gln Pro Thr Ile Ser Asn Gly Ser Asp Lys Leu Thr 
        915                 920                 925             


Gly Leu Asn Tyr Asn Val Leu Lys Ser Phe Leu Ser Thr Tyr Gly Ile 
    930                 935                 940                 


Ala Thr Asp Ile Asp Asp Leu Thr Ala Val Leu His 
945                 950                 955     


<210>  2337
<211>  1088
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2337

Met Lys Lys Phe Asp Phe Lys Leu Lys Glu Thr Asp Tyr Thr Arg Leu 
1               5                   10                  15      


Tyr Ser Glu Gln Thr Asp Cys Lys Arg His Val Val Gly Ala Tyr Ala 
            20                  25                  30          


Asn Leu Ala Leu His Asn Met Thr Thr Val Val Asn Ser Ile Arg Gln 
        35                  40                  45              


Ala Val Gly Leu Asp Thr Ile Thr Asp Asp Thr Ile Lys Asp Ala Phe 
    50                  55                  60                  


Ser Arg Asp Ser Phe Lys Gly Leu Asp Ala Gly Asn Gln Leu Lys Leu 
65                  70                  75                  80  


Gln Asn Lys Leu Phe Arg His Phe Pro Phe Leu Arg Arg Met Lys Leu 
                85                  90                  95      


Glu Gln His Gly Thr Leu Asp Tyr Ser Glu Val Ile Asn Asp Phe Ile 
            100                 105                 110         


Lys Leu Met Ser Ile Ile Arg Asp Asp Phe Ser His Tyr Cys Pro Tyr 
        115                 120                 125             


Ser Asp Glu Ser Gln Gln Thr Glu Asn Ser Leu Ile Lys Lys Asn Ala 
    130                 135                 140                 


Ser Glu Lys Leu Lys Glu Ile Phe Thr Asn Ser Val Ser Gln Tyr Leu 
145                 150                 155                 160 


His Thr Ala Glu Glu Asn Glu Val Arg Asp Ser Val Gln Asn Ser Lys 
                165                 170                 175     


Thr Gln Gln Asp Asn Lys Val Thr Ile Thr Glu Asn Ser Ile Asp Met 
            180                 185                 190         


Arg Asp Pro Ala Ser Lys Asp Gly Leu Thr Asp Ala Gly Ile Val Phe 
        195                 200                 205             


Phe Leu Cys Cys Phe Leu Glu Lys His Thr Ala Phe Glu Phe Leu Glu 
    210                 215                 220                 


Glu Ile Lys Phe Thr Glu Gly Leu Asn Pro Ala Asn Ala Leu Tyr Val 
225                 230                 235                 240 


Lys Glu Ile Leu Cys Met Asn Arg Ile Arg Met Thr Arg Ser Gln Ile 
                245                 250                 255     


Asp Ser Gln Met Ser Asp Thr Ala Leu Ala Leu Asp Met Met Asn Glu 
            260                 265                 270         


Leu Arg Lys Cys Pro Lys Pro Leu Tyr Asp Val Leu Asp Pro Ala Ser 
        275                 280                 285             


Arg Asn Tyr Phe Lys Asp Asp Ala Asn Leu Gln Trp Glu Glu Asp Asn 
    290                 295                 300                 


Pro Thr Gln Thr Asp Ser Gln Ser Pro Asp Ser His Asn Ile Thr Asp 
305                 310                 315                 320 


Leu Arg Ala Lys Ser Val Pro Arg Ser Thr Phe Val Arg Trp Gln Asn 
                325                 330                 335     


Arg Phe Pro Glu Met Ala Leu Cys Phe Ile Asp Leu Lys Gly Leu Phe 
            340                 345                 350         


Lys Thr Thr Arg Phe Gln Leu Arg Leu Gly Asn Tyr Arg Tyr Arg Phe 
        355                 360                 365             


Tyr Thr His Thr Ala Gln Gln Ser Leu Asp Gly Arg Glu Arg Leu Arg 
    370                 375                 380                 


Ile Leu Gln Lys Glu Leu His Gly Phe Gly Arg Ile Asn Glu Ile Glu 
385                 390                 395                 400 


Gln Thr Ile Lys Lys Glu Trp Gly Gln Tyr Ile Glu Lys Asn Thr Thr 
                405                 410                 415     


Asp Pro Lys Pro Lys Asp Gln Pro Asp Arg Thr Pro Tyr Ile Thr His 
            420                 425                 430         


Gln Arg Pro Gln Tyr Asn Ile Asp Pro Val Ser His Ser Ile Gly Leu 
        435                 440                 445             


Arg Trp Asp Phe Pro Asn Lys Lys Thr Lys Tyr Tyr Ile Pro Glu Ile 
    450                 455                 460                 


Gln Pro Gln Gln Lys Cys Pro Ser Glu Asn Leu Ala Pro Gln Cys Tyr 
465                 470                 475                 480 


Leu Asn Thr Asp Glu Leu Pro Ala Leu Leu Phe Tyr Gln Tyr Ile Lys 
                485                 490                 495     


Asn Thr Tyr Ser Pro Asn Lys Gly Ser Ser Ala Glu Asn Ile Ile Arg 
            500                 505                 510         


Lys Cys Tyr Ile Asn Leu His Thr Leu Phe Ser Gln Leu Ala Lys Asn 
        515                 520                 525             


Glu Lys Ile Ser Ile Asn Glu Leu Asp Lys Trp Glu Leu Arg Pro Ser 
    530                 535                 540                 


Asp Ile Pro Ala Lys Ile Arg Lys Leu Met Glu Gly His Glu Arg Ser 
545                 550                 555                 560 


Glu Gln Glu Ile Arg Asp Ser Leu Arg Arg Ser Ile Glu His Gln Leu 
                565                 570                 575     


Ala Leu Ile Asp Lys Thr Thr Tyr Glu Arg Leu Val Lys Tyr Glu Ala 
            580                 585                 590         


Ala Thr Asp Lys Lys Glu Gln Thr Asp Lys Lys Thr Thr Arg Phe Arg 
        595                 600                 605             


Pro Pro Ile Leu Thr Gly Arg Leu Ala Gln Gln Leu Ile Asp Asp Ile 
    610                 615                 620                 


Val Trp Trp Leu Pro Thr Asp Ser Pro Cys Arg Ser Arg Leu Thr Ser 
625                 630                 635                 640 


Glu Lys Tyr Asn Ile Leu Gln Ala Ser Ile Ala Leu Leu Gly Gln Trp 
                645                 650                 655     


Thr Asp Ala Ser Asp Pro Ser Gln Gln Thr Val Thr Ile Asp Asp Leu 
            660                 665                 670         


Arg Gln Met Met Glu Lys Ile Gly Leu Leu Gly Pro Asp Gly His Pro 
        675                 680                 685             


Phe Leu Ser Gln Val Phe Lys Gln Pro Ile Gln Ser Ala Gly Phe Phe 
    690                 695                 700                 


Tyr His Asn Tyr Leu Tyr Ala Glu Gln Asp His Ile Glu Thr Leu Trp 
705                 710                 715                 720 


Gln Asp Phe Asp His Asn Leu Asp Gln Leu Ile Ser Gln Ala His Ala 
                725                 730                 735     


Lys Leu Pro Phe Val His Ile Asp Arg Pro Lys Trp Asn Val Asp Lys 
            740                 745                 750         


Ser Asn Asn Leu Ser Gln Leu Ala Gln Glu Tyr Leu Thr His Pro Leu 
        755                 760                 765             


Gln Leu Pro Leu Gly Leu Phe Ala Gln Pro Ile Ala Gln Leu Leu Arg 
    770                 775                 780                 


Asp Ile Ala Glu Gly Glu Ala Thr Glu Thr Trp Lys Gln Leu Thr Ala 
785                 790                 795                 800 


Glu Ile Asp Arg Leu Thr Gln Lys Gly Gln Pro Ser Thr Leu Lys Leu 
                805                 810                 815     


Ile Glu Leu Tyr His Lys Asn Ile Glu Glu Asp Asp Phe Gln Asn Phe 
            820                 825                 830         


Tyr Asn Ser Ser Pro Asn Ala Gly Phe Gln His His Tyr Glu Leu Phe 
        835                 840                 845             


Lys Lys Ile Tyr Lys Glu Lys Gly Arg Ser Val Glu Glu Val Phe Asn 
    850                 855                 860                 


Leu Leu Arg Arg Lys Ser Asn Pro Pro Gln Ser Lys Ser Gln Leu Asp 
865                 870                 875                 880 


Cys Asp Ile His Glu Tyr Val Glu Lys His Arg Lys Asp Lys Ser Lys 
                885                 890                 895     


Glu Trp Ala Glu Asp Gln Thr Thr Leu Met Arg Lys Gln Ala Lys Gln 
            900                 905                 910         


Val Glu Gln Thr Glu His Ala Ile Arg Arg Cys Gln Ile Glu Asp Ile 
        915                 920                 925             


Val Met Leu Tyr Ala Ala Arg Val Met Leu Tyr Ala Ala Arg Asp Ile 
    930                 935                 940                 


Leu Ser Ala Lys Asn Asn Arg Thr Pro Asn Gly Thr Asp Thr His Gln 
945                 950                 955                 960 


Pro Gln Lys Phe Lys Leu Lys His Val Gln Asn Asp Asp Gly Leu Leu 
                965                 970                 975     


Glu Arg Thr Ile Asp Phe Asn Trp Val Val Asp Ile Glu Gly Gln Gln 
            980                 985                 990         


Lys Thr Ile Arg Gln Gln Asn Met  Lys Met Lys Asp Tyr  Gly Lys Phe 
        995                 1000                 1005             


Tyr Lys  Phe Ala Ser Asp Gly  Glu Arg Leu Glu Ser  Leu Leu Ala 
    1010                 1015                 1020             


His Leu  Gly Gly Asn Glu Phe  Gln Arg Ala Asp Ile  Glu Ala Glu 
    1025                 1030                 1035             


Tyr Ala  Gln Tyr Asp Asp Cys  Arg Ser Gln Val Phe  Arg Tyr Val 
    1040                 1045                 1050             


Tyr Met  Leu Glu Ser Lys Ala  Tyr Gln Leu Leu Ala  Met Gln Lys 
    1055                 1060                 1065             


Asp Asn  Pro Ile Asp Leu Leu  Asp Asp Lys Asn Ser  Thr Arg Asp 
    1070                 1075                 1080             


Glu Phe  Trp Phe Val 
    1085             


<210>  2338
<211>  985
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2338

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Asn Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys Gly Tyr 
                165                 170                 175     


Ala Phe Phe Ile Ser Lys Phe Leu Glu Arg Lys Tyr Ser Tyr Leu Phe 
            180                 185                 190         


Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln Tyr Arg 
        195                 200                 205             


Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro Val Glu 
    210                 215                 220                 


Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu Asp Ile 
225                 230                 235                 240 


Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr Leu Glu 
                245                 250                 255     


Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr Asp Ala 
            260                 265                 270         


Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe Arg Ser 
        275                 280                 285             


Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala Asp Phe 
    290                 295                 300                 


Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His Asn Gly 
305                 310                 315                 320 


Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr Ile Asn 
                325                 330                 335     


Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser Ala Lys 
            340                 345                 350         


Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser Thr Asp 
        355                 360                 365             


Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln Ser Thr 
    370                 375                 380                 


Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val Leu Pro 
385                 390                 395                 400 


Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala Lys Met 
                405                 410                 415     


Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala Met Leu 
            420                 425                 430         


Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His Cys Pro 
        435                 440                 445             


Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser Thr Lys 
    450                 455                 460                 


Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg Val Met 
465                 470                 475                 480 


Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu Arg Ile 
                485                 490                 495     


Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile Leu Lys 
            500                 505                 510         


Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp Leu Gln 
        515                 520                 525             


Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn Phe Gln 
    530                 535                 540                 


Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn Asp Leu 
545                 550                 555                 560 


Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn Pro His 
                565                 570                 575     


Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile Glu Phe 
            580                 585                 590         


Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg Ile Gln 
        595                 600                 605             


Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro Leu Arg 
    610                 615                 620                 


Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu Ala Ile 
625                 630                 635                 640 


Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys Leu Lys 
                645                 650                 655     


Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu Lys Ser 
            660                 665                 670         


Pro Ala Leu Asn Val Ser Tyr Leu Ile His Asn Tyr Phe Arg Ala Tyr 
        675                 680                 685             


Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn Tyr Arg 
    690                 695                 700                 


Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser Tyr Leu 
705                 710                 715                 720 


Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro Ser Lys 
                725                 730                 735     


Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp Arg Leu 
            740                 745                 750         


Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile Ile Arg 
        755                 760                 765             


Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys Glu Tyr 
    770                 775                 780                 


Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu Glu Asn 
785                 790                 795                 800 


Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp Leu Asn 
                805                 810                 815     


Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr Gly Lys 
            820                 825                 830         


Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn Lys Val 
        835                 840                 845             


Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val Lys Ile 
    850                 855                 860                 


Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu Glu Ala 
865                 870                 875                 880 


Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala Met Val 
                885                 890                 895     


Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr Tyr Asp 
            900                 905                 910         


Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln Lys Ile 
        915                 920                 925             


Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His Asp Lys 
    930                 935                 940                 


Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val Tyr Ala 
945                 950                 955                 960 


Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile Lys Leu 
                965                 970                 975     


Glu Asp Leu Ser Asn Asp Ser Ser Ala 
            980                 985 


<210>  2339
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2339

Leu Gln Lys Gln Asp Lys Leu Phe Val Asp Arg Lys Lys Asn Ala Ile 
1               5                   10                  15      


Phe Ala Phe Pro Lys Tyr Ile Thr Ile Met Glu Asn Lys Glu Lys Thr 
            20                  25                  30          


Glu Pro Ile Tyr Tyr Glu Leu Thr Asp Lys His Phe Trp Ala Ala Phe 
        35                  40                  45              


Leu Asn Leu Ala Arg His Asn Val Tyr Thr Thr Ile Asn His Ile Asn 
    50                  55                  60                  


Arg Arg Leu Glu Ile Ala Glu Leu Lys Asp Asp Gly Tyr Met Met Gly 
65                  70                  75                  80  


Ile Lys Gly Ser Trp Asn Glu Gln Ala Lys Lys Leu Asp Lys Lys Val 
                85                  90                  95      


Arg Leu Arg Asp Leu Ile Met Lys His Phe Pro Phe Leu Glu Ala Ala 
            100                 105                 110         


Ala Tyr Glu Met Thr Asn Ser Lys Ser Pro Asn Asn Lys Glu Gln Arg 
        115                 120                 125             


Glu Lys Glu Gln Ser Glu Ala Leu Ser Leu Asn Asn Leu Lys Asn Val 
    130                 135                 140                 


Leu Phe Ile Phe Leu Glu Lys Leu Gln Val Leu Arg Asn Tyr Tyr Ser 
145                 150                 155                 160 


His Tyr Lys Tyr Ser Glu Glu Ser Pro Lys Pro Ile Phe Glu Thr Ser 
                165                 170                 175     


Leu Leu Lys Asn Met Tyr Lys Val Phe Asp Ala Asn Val Arg Leu Val 
            180                 185                 190         


Lys Arg Asp Tyr Met His His Glu Asn Ile Asp Met Gln Arg Asp Phe 
        195                 200                 205             


Thr His Leu Asn Arg Lys Lys Gln Val Gly Arg Thr Lys Asn Ile Ile 
    210                 215                 220                 


Asp Ser Pro Asn Phe His Tyr His Phe Ala Asp Lys Glu Gly Asn Met 
225                 230                 235                 240 


Thr Ile Ala Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Asp Lys Lys 
                245                 250                 255     


Asp Ala Ile Trp Met Gln Lys Lys Leu Lys Gly Phe Lys Asp Gly Arg 
            260                 265                 270         


Asn Leu Arg Glu Gln Met Thr Asn Glu Val Phe Cys Arg Ser Arg Ile 
        275                 280                 285             


Ser Leu Pro Lys Leu Lys Leu Glu Asn Val Gln Thr Lys Asp Trp Met 
    290                 295                 300                 


Gln Leu Asp Met Leu Asn Glu Leu Val Arg Cys Pro Lys Ser Leu Tyr 
305                 310                 315                 320 


Glu Arg Leu Arg Glu Lys Asp Arg Glu Ser Phe Lys Val Pro Phe Asp 
                325                 330                 335     


Ile Phe Ser Asp Asp Tyr Asp Ala Glu Glu Glu Pro Phe Lys Asn Thr 
            340                 345                 350         


Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe 
        355                 360                 365             


Asp Leu Asn Glu Ile Phe Glu Gln Leu Arg Phe Gln Ile Asp Leu Gly 
    370                 375                 380                 


Thr Tyr His Phe Ser Ile Tyr Asn Lys Leu Ile Gly Asp Glu Asp Glu 
385                 390                 395                 400 


Val Arg His Leu Thr His His Leu Tyr Gly Phe Ala Arg Ile Gln Asp 
                405                 410                 415     


Phe Ala Pro Gln Asn Gln Pro Glu Glu Trp Arg Lys Leu Val Lys Asp 
            420                 425                 430         


Leu Asp His Phe Glu Thr Ser Gln Lys Pro Tyr Ile Ser Lys Thr Ala 
        435                 440                 445             


Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Lys Phe Cys Ser 
    450                 455                 460                 


Thr His Asn Asn Leu Phe Pro Ser Leu Lys Arg Glu Lys Thr Cys Asn 
465                 470                 475                 480 


Gly Arg Ser Lys Phe Asn Leu Gly Thr Gln Phe Thr Ala Glu Ala Phe 
                485                 490                 495     


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu 
            500                 505                 510         


Thr Lys Asp Tyr Ser Arg Lys Glu Ser Ala Asp Lys Val Glu Gly Ile 
        515                 520                 525             


Ile Arg Lys Glu Ile Ser Asn Ile Tyr Ala Ile Tyr Asp Ala Phe Ala 
    530                 535                 540                 


Asn Asn Glu Ile Asn Ser Ile Ala Asp Leu Thr Cys Arg Leu Gln Lys 
545                 550                 555                 560 


Thr Asn Ile Leu Gln Gly His Leu Pro Lys Gln Met Ile Ser Ile Leu 
                565                 570                 575     


Glu Gly Arg Gln Lys Asp Met Glu Lys Glu Ala Glu Arg Lys Ile Gly 
            580                 585                 590         


Glu Met Ile Asp Asp Thr Gln Arg Arg Leu Asp Leu Leu Cys Lys Gln 
        595                 600                 605             


Thr Asn Gln Lys Ile Arg Ile Gly Lys Arg Asn Ala Gly Leu Leu Lys 
    610                 615                 620                 


Ser Gly Lys Ile Ala Asp Trp Leu Val Asn Asp Met Met Arg Phe Gln 
625                 630                 635                 640 


Pro Val Gln Lys Asp Gln Asn Asn Ile Pro Ile Asn Asn Ser Lys Ala 
                645                 650                 655     


Asn Ser Thr Glu Tyr Arg Met Leu Gln Arg Ala Leu Ala Leu Phe Gly 
            660                 665                 670         


Ser Glu Asn Phe Arg Leu Lys Ala Tyr Phe Asn Gln Met Asn Leu Val 
        675                 680                 685             


Gly Asn Asp Asn Pro His Pro Phe Leu Ala Glu Thr Gln Trp Glu His 
    690                 695                 700                 


Gln Thr Asn Ile Leu Ser Phe Tyr Arg Asn Tyr Leu Glu Ala Arg Lys 
705                 710                 715                 720 


Lys Tyr Leu Lys Gly Leu Lys Pro Gln Asn Trp Lys Gln Tyr Gln His 
                725                 730                 735     


Phe Leu Ile Leu Lys Val Gln Lys Thr Asn Arg Asn Thr Leu Val Thr 
            740                 745                 750         


Gly Trp Lys Asn Ser Phe Asn Leu Pro Arg Gly Ile Phe Thr Gln Pro 
        755                 760                 765             


Ile Arg Glu Trp Phe Glu Lys His Asn Asn Ser Lys Arg Ile Tyr Asp 
    770                 775                 780                 


Gln Ile Leu Ser Phe Asp Arg Val Gly Phe Val Ala Lys Ala Ile Pro 
785                 790                 795                 800 


Leu Tyr Phe Ala Gly Glu Tyr Lys Asp Asn Val Gln Pro Phe Tyr Asp 
                805                 810                 815     


Tyr Pro Phe Asn Ile Gly Asn Lys Leu Lys Pro Gln Lys Gly Gln Phe 
            820                 825                 830         


Leu Asp Lys Lys Glu Arg Val Glu Leu Trp Gln Lys Asn Lys Glu Leu 
        835                 840                 845             


Phe Lys Asn Tyr Pro Pro Glu Lys Arg Lys Thr Asp Leu Ala Tyr Leu 
    850                 855                 860                 


Asp Phe Leu Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys 
865                 870                 875                 880 


Asn Gln Asp Ile Val Thr Trp Leu Met Phe Lys Glu Leu Phe Lys Thr 
                885                 890                 895     


Thr Thr Val Glu Gly Leu Lys Ile Gly Glu Ile His Leu Arg Asp Ile 
            900                 905                 910         


Asp Thr Asn Thr Ala Asn Glu Glu Ser Asn Asn Ile Leu Asn Arg Ile 
        915                 920                 925             


Met Pro Met Lys Leu Pro Val Lys Thr Tyr Glu Thr Asp Asn Lys Gly 
    930                 935                 940                 


Asn Ile Leu Lys Glu Arg Pro Leu Ala Thr Phe Tyr Ile Glu Glu Thr 
945                 950                 955                 960 


Glu Thr Lys Val Leu Lys Gln Gly Asn Phe Lys Val Leu Ala Lys Asp 
                965                 970                 975     


Arg Arg Leu Asn Gly Leu Leu Ser Phe Ala Glu Thr Thr Asp Ile Asp 
            980                 985                 990         


Leu Glu Lys Asn Pro Ile Thr Lys  Leu Ser Val Asp His  Glu Leu Ile 
        995                 1000                 1005             


Lys Tyr  Gln Thr Thr Arg Ile  Ser Ile Phe Glu Met  Thr Leu Gly 
    1010                 1015                 1020             


Leu Glu  Lys Lys Leu Ile Asn  Lys Tyr Pro Thr Leu  Pro Thr Asp 
    1025                 1030                 1035             


Ser Phe  Arg Asn Met Leu Glu  Arg Trp Leu Gln Cys  Lys Ala Asn 
    1040                 1045                 1050             


Arg Pro  Glu Leu Lys Asn Tyr  Val Asn Ser Leu Ile  Ala Val Arg 
    1055                 1060                 1065             


Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met Tyr Asp  Ala Thr Leu 
    1070                 1075                 1080             


Phe Ala  Glu Val Lys Lys Phe  Thr Leu Phe Pro Ser  Val Asp Thr 
    1085                 1090                 1095             


Lys Lys  Ile Glu Leu Asn Ile  Ala Pro Gln Leu Leu  Glu Ile Val 
    1100                 1105                 1110             


Gly Lys  Ala Ile Lys Glu Ile  Glu Lys Ser Glu Asn  Lys Asn 
    1115                 1120                 1125         


<210>  2340
<211>  1110
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2340

Leu Gln Lys Gln Asp Lys Leu Phe Val Asp Arg Lys Lys Asn Ala Ile 
1               5                   10                  15      


Phe Ala Phe Pro Lys Tyr Ile Thr Ile Met Glu Asn Lys Glu Lys Pro 
            20                  25                  30          


Glu Pro Ile Tyr Tyr Glu Leu Thr Asp Lys His Phe Trp Ala Ala Phe 
        35                  40                  45              


Leu Asn Leu Ala Arg His Asn Val Tyr Thr Thr Ile Asn His Ile Asn 
    50                  55                  60                  


Arg Arg Leu Glu Ile Ala Glu Leu Lys Asp Asp Gly Tyr Met Met Gly 
65                  70                  75                  80  


Ile Lys Gly Ser Trp Asn Glu Gln Ala Lys Lys Leu Asp Lys Lys Val 
                85                  90                  95      


Arg Leu Arg Asp Leu Ile Met Lys His Phe Pro Phe Leu Glu Ala Ala 
            100                 105                 110         


Ala Tyr Glu Ile Thr Asn Ser Lys Ser Pro Asn Asn Lys Glu Gln Arg 
        115                 120                 125             


Glu Lys Glu Gln Ser Glu Ala Leu Ser Leu Asn Asn Leu Lys Asn Val 
    130                 135                 140                 


Leu Phe Ile Phe Leu Glu Lys Leu Gln Val Leu Arg Asn Tyr Tyr Ser 
145                 150                 155                 160 


His Tyr Lys Tyr Ser Glu Glu Ser Pro Lys Pro Ile Phe Glu Thr Ser 
                165                 170                 175     


Leu Leu Lys Asn Met Tyr Lys Val Phe Asp Ala Asn Val Arg Leu Val 
            180                 185                 190         


Lys Arg Asp Tyr Met His His Glu Asn Ile Asp Met Gln Arg Asp Phe 
        195                 200                 205             


Thr His Leu Asn Arg Lys Lys Gln Val Gly Arg Thr Lys Asn Ile Ile 
    210                 215                 220                 


Asp Ser Pro Asn Phe His Tyr His Phe Ala Asp Lys Glu Gly Asn Met 
225                 230                 235                 240 


Thr Ile Ala Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Asp Lys Lys 
                245                 250                 255     


Asp Ala Ile Trp Met Gln Lys Lys Leu Lys Gly Phe Lys Asp Gly Arg 
            260                 265                 270         


Asn Leu Arg Glu Gln Met Thr Asn Glu Val Phe Cys Arg Ser Arg Ile 
        275                 280                 285             


Ser Leu Pro Lys Leu Lys Leu Glu Asn Val Gln Thr Lys Asp Trp Met 
    290                 295                 300                 


Gln Leu Asp Met Leu Asn Glu Leu Val Arg Cys Pro Lys Ser Leu Tyr 
305                 310                 315                 320 


Glu Arg Leu Arg Glu Lys Asp Arg Glu Ser Phe Lys Val Pro Phe Asp 
                325                 330                 335     


Ile Phe Ser Asp Asp Tyr Asp Ala Glu Glu Glu Pro Phe Lys Asn Thr 
            340                 345                 350         


Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe 
        355                 360                 365             


Asp Leu Asn Glu Ile Phe Glu Gln Leu Arg Phe Gln Ile Asp Leu Gly 
    370                 375                 380                 


Thr Tyr His Phe Ser Ile Tyr Asn Lys Arg Ile Gly Asp Glu Asp Glu 
385                 390                 395                 400 


Val Arg His Leu Thr His His Leu Tyr Gly Phe Ala Arg Ile Gln Asp 
                405                 410                 415     


Phe Ala Pro Gln Asn Gln Pro Glu Glu Trp Arg Lys Leu Val Lys Asp 
            420                 425                 430         


Leu Asp His Phe Glu Thr Ser Gln Glu Pro Tyr Ile Ser Lys Thr Ala 
        435                 440                 445             


Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Lys Phe Cys Ser 
    450                 455                 460                 


Thr His Asn Asn Leu Phe Pro Ser Leu Lys Arg Glu Lys Thr Cys Asn 
465                 470                 475                 480 


Gly Arg Ser Lys Phe Asn Leu Gly Thr Gln Phe Thr Ala Glu Ala Phe 
                485                 490                 495     


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu 
            500                 505                 510         


Thr Lys Asp His Pro Lys Gly Glu Gly Val Asn Lys Ile Glu Lys Ile 
        515                 520                 525             


Ile Arg Thr Glu Ile Ser Asn Ile Tyr Asp Ile Tyr Asp Ala Phe Ala 
    530                 535                 540                 


Asn Gly Glu Ile Asn Ser Ile Ala Asp Leu Thr Cys Arg Leu Gln Lys 
545                 550                 555                 560 


Thr Asn Ile Leu Gln Gly His Leu Pro Lys Gln Met Ile Ser Ile Leu 
                565                 570                 575     


Glu Gly Arg Gln Lys Asp Met Glu Lys Glu Ala Glu Arg Lys Ile Gly 
            580                 585                 590         


Glu Met Ile Asp Asp Thr Gln Arg Arg Leu Asp Leu Leu Cys Lys Gln 
        595                 600                 605             


Thr Asn Gln Lys Ile Arg Ile Gly Lys Arg Asn Ala Gly Leu Leu Lys 
    610                 615                 620                 


Ser Gly Lys Ile Ala Asp Trp Leu Val Ser Asp Met Met Arg Phe Gln 
625                 630                 635                 640 


Pro Val Gln Lys Asp Thr Asn Asn Ala Pro Ile Asn Asn Ser Lys Ala 
                645                 650                 655     


Asn Ser Thr Glu Tyr Arg Met Leu Gln His Ala Leu Ala Leu Phe Gly 
            660                 665                 670         


Ser Glu Ser Ser Arg Leu Lys Ala Tyr Phe Arg Gln Met Asn Leu Val 
        675                 680                 685             


Gly Asn Ala Asn Pro His Pro Phe Leu Ala Glu Thr Gln Trp Glu His 
    690                 695                 700                 


Gln Thr Asn Ile Leu Ser Phe Tyr Arg Asn Tyr Leu Glu Ala Arg Lys 
705                 710                 715                 720 


Lys Tyr Leu Lys Gly Leu Lys Pro Gln Asn Trp Lys Gln Tyr Gln His 
                725                 730                 735     


Phe Leu Ile Leu Lys Val Gln Lys Thr Asn Arg Asn Thr Leu Val Thr 
            740                 745                 750         


Gly Trp Lys Asn Ser Phe Asn Leu Pro Arg Gly Ile Phe Thr Gln Pro 
        755                 760                 765             


Ile Arg Glu Trp Phe Glu Lys His Asn Asn Ser Lys Arg Ile Tyr Asp 
    770                 775                 780                 


Gln Ile Leu Ser Phe Asp Arg Val Gly Phe Val Ala Lys Ala Ile Pro 
785                 790                 795                 800 


Leu Tyr Phe Ala Glu Glu Tyr Lys Asp Asn Val Gln Pro Phe Tyr Asp 
                805                 810                 815     


Tyr Pro Phe Asn Ile Gly Asn Lys Leu Lys Pro Gln Lys Gly Gln Phe 
            820                 825                 830         


Leu Asp Lys Lys Glu Arg Val Glu Leu Trp Gln Lys Asn Lys Glu Leu 
        835                 840                 845             


Phe Lys Asn Tyr Pro Ser Glu Lys Lys Lys Thr Asp Leu Ala Tyr Leu 
    850                 855                 860                 


Asp Phe Leu Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys 
865                 870                 875                 880 


Asn Gln Asp Ile Val Thr Trp Leu Met Phe Lys Glu Leu Phe Asn Met 
                885                 890                 895     


Ala Thr Val Glu Gly Leu Lys Ile Gly Glu Ile His Leu Arg Asp Ile 
            900                 905                 910         


Asp Thr Asn Thr Ala Lys Ala Glu Ser Asn Asn Ile Leu Asn Arg Ile 
        915                 920                 925             


Met Pro Met Lys Leu Pro Val Lys Thr Tyr Glu Thr Asp Asn Lys Gly 
    930                 935                 940                 


Asn Ile Leu Lys Glu Arg Pro Leu Ala Thr Phe Tyr Ile Glu Glu Thr 
945                 950                 955                 960 


Glu Thr Lys Val Leu Lys Gln Gly Asn Phe Lys Val Leu Ala Lys Asp 
                965                 970                 975     


Arg Arg Leu Asn Gly Leu Leu Ser Phe Ala Glu Thr Thr Asp Ile Asp 
            980                 985                 990         


Leu Glu Lys Asn Pro Ile Thr Lys  Leu Ser Val Asp His  Glu Leu Ile 
        995                 1000                 1005             


Lys Tyr  Gln Thr Thr Arg Ile  Ser Ile Phe Glu Met  Thr Leu Gly 
    1010                 1015                 1020             


Leu Glu  Lys Lys Leu Ile Asp  Lys Tyr Ser Thr Leu  Pro Thr Asp 
    1025                 1030                 1035             


Ser Phe  Arg Asn Met Leu Glu  Arg Trp Leu Gln Cys  Lys Ala Asn 
    1040                 1045                 1050             


Arg Pro  Glu Leu Lys Asn Tyr  Val Asn Ser Leu Ile  Ala Val Arg 
    1055                 1060                 1065             


Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met Tyr Asp  Ala Thr Leu 
    1070                 1075                 1080             


Phe Ala  Glu Val Lys Lys Phe  Thr Leu Phe Pro Ser  Val Asp Thr 
    1085                 1090                 1095             


Lys Lys  Ile Glu Leu Asn Ile  Ala Pro Gln Leu Leu  
    1100                 1105                 1110 


<210>  2341
<211>  1107
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2341

Met Ser Thr Arg Tyr Thr Asn Gln Lys Lys Val Glu Glu Asn Ile Asn 
1               5                   10                  15      


Tyr Val Phe Ser Asn Lys Gly Ile Phe Ala Ala Val Ala Glu Lys Thr 
            20                  25                  30          


Leu Thr Asn Tyr Lys Ser Lys Phe Asn Glu Gly Gln Thr Ile Gln Pro 
        35                  40                  45              


Asn Leu His Tyr Phe Ala Val Gly His Thr Phe Lys Asn Ile Asp Thr 
    50                  55                  60                  


Lys Arg Ile Phe Asp Tyr Gln Leu Ser Glu Asp Glu Met Asp Ile Leu 
65                  70                  75                  80  


Pro Thr Lys Tyr Phe Ser Leu Gln Gln Asn Lys Phe Ser Phe Pro Ile 
                85                  90                  95      


Asp Gly Gln Thr Lys Thr Asp Lys Leu Tyr Leu Leu Leu Asp Asn Ile 
            100                 105                 110         


Arg Asn Ile Asn Ala His Phe Ile His Asp Phe Asn Phe Leu Lys Val 
        115                 120                 125             


Asp Asn Ile Asp Glu Asn Ile Ile Cys Phe Leu Ile Asp Ser Phe Glu 
    130                 135                 140                 


Leu Ala Leu Ile Lys Gly Val Phe Ala Lys Lys Tyr Gly Asp Lys Lys 
145                 150                 155                 160 


Ser Lys Leu Arg Leu Asp Phe Leu Ser Asn Glu Ala Arg Asp Glu Ile 
                165                 170                 175     


Leu Thr Asp Ile Leu Glu Asn Leu Asp Lys Glu Leu Ile Val Phe Met 
            180                 185                 190         


Lys Glu Ile Phe Tyr Gln Thr Leu Tyr Val Val Asp Lys Lys Glu Trp 
        195                 200                 205             


Arg Asn Lys Glu Leu Asn Gln Glu Lys Lys Asp Phe Leu Asp Asn His 
    210                 215                 220                 


Leu Ser Ser Lys Glu Asp Trp Ile Asn Trp Ile Leu Phe Asn Cys Val 
225                 230                 235                 240 


Glu Glu Asp Ile Asp Trp Tyr Leu Asn Asn Tyr Gly Asp Tyr Asp Pro 
                245                 250                 255     


His Pro Asp Ser Lys Asn His Lys His Lys Val Leu Thr Ile Glu Lys 
            260                 265                 270         


Gly Lys Tyr Leu Ser Phe Glu Gly Ser Leu Phe Met Met Thr Met Phe 
        275                 280                 285             


Leu Tyr Ala Asn Glu Ala Asn Tyr Leu Ile Pro Lys Leu Lys Gly Tyr 
    290                 295                 300                 


Lys Lys Asn Gly Thr Pro Gln Asp Ala Ser Lys Leu Glu Val Phe Arg 
305                 310                 315                 320 


Phe Phe Ala Lys Lys Phe Lys Ser Gln Asp Val Asp Ser Glu His Lys 
                325                 330                 335     


Gln Tyr Val Lys Phe Arg Asp Met Ile Gln Tyr Val Gly Lys Tyr Pro 
            340                 345                 350         


Thr Val Trp Asn Lys His Ile His Leu Asp Ser Tyr Tyr Val Lys Asp 
        355                 360                 365             


Leu Lys Ala Thr Ile Leu Glu Asn Glu Ile Ile Gln Leu Tyr Gln Glu 
    370                 375                 380                 


Asp Ile Lys Asn His Phe Gln Ser Ile Cys Gly Leu Lys Gln Phe Glu 
385                 390                 395                 400 


Asp Ser Gln Glu Glu Ile Gln Leu Ala Phe Ile Glu Val Ala Lys Asp 
                405                 410                 415     


Tyr Leu Gln Asn Lys Glu Ile Tyr Tyr Thr Gly Glu Tyr Arg Glu Asp 
            420                 425                 430         


Cys Ile Thr Ile Leu Lys Thr Ser Ala Glu His Leu Ala Asn Lys Arg 
        435                 440                 445             


Gln Leu Lys Asp Ile Gln Lys Gln Leu Lys Lys Tyr Ile Asn Lys Ala 
    450                 455                 460                 


Tyr Lys Ser Leu Ser Ser Glu Asp Gln Gly Lys Lys Lys Lys Leu Asp 
465                 470                 475                 480 


Ile Ser Lys Leu Lys Tyr Ile Asp Lys Ile Arg Lys Ser Lys Asn Ser 
                485                 490                 495     


Ile Asn Thr Thr Thr Asp Lys Phe Ala Lys Arg Val Glu Asp Asn Leu 
            500                 505                 510         


Leu Phe Ile Ser Asn Gly Arg Asn Ser Asp Arg Phe Met Val Phe Ala 
        515                 520                 525             


Cys Arg Phe Leu Ala Glu Ile Asn Tyr Phe Gly Lys Asp Ala Gln Phe 
    530                 535                 540                 


Lys Met Tyr Glu Asn Tyr Tyr Ser Glu Glu Glu Gln Asn Ala Leu Lys 
545                 550                 555                 560 


Asp Lys Lys Gln Asn Leu Thr Gln Lys Glu Phe Asp Lys Leu His Tyr 
                565                 570                 575     


His Gly Gly Lys Leu Thr His Phe Glu Thr Phe Glu Asn His Thr Lys 
            580                 585                 590         


Lys Tyr Pro Asn Trp Asp Met Pro Phe Val Val Gln Asn Asn Ala Ile 
        595                 600                 605             


Tyr Val Lys Ile Pro Gly Ile Asn Phe Ile Lys Asn Thr Ala Phe Cys 
    610                 615                 620                 


Ile Gln Arg Asn Val Ile Asn Tyr Leu Leu Glu His Ala Leu Gly Glu 
625                 630                 635                 640 


Asn Tyr Lys Asp Gln Gln Gly Arg Lys Trp Leu Phe Asp Tyr Tyr Glu 
                645                 650                 655     


His Lys Thr Glu Ala Thr Asp Asn Ala Lys Arg Ile Leu Thr Glu Ser 
            660                 665                 670         


Lys Pro Ile Glu Ala Ser Ser Lys Thr Lys Leu Lys Lys Leu Leu Pro 
        675                 680                 685             


Lys Lys Leu Phe Pro Lys Tyr Ser Ala Ser Glu Thr Glu Lys Asn Ile 
    690                 695                 700                 


Leu Arg Lys Tyr Leu Glu Gln Ala Glu Glu Ser Glu Lys Leu Tyr Glu 
705                 710                 715                 720 


Asn Gln Lys Asp Lys Ala Lys Ala Glu Asn Arg Leu Asp Leu Phe Val 
                725                 730                 735     


Asn Lys Asn Lys Gly Lys Gln Phe Lys Leu Arg Phe Ile Phe Lys Ala 
            740                 745                 750         


Trp Gln Leu Met Tyr Phe Lys Lys Gln Tyr Gln Ile Glu Lys Glu Arg 
        755                 760                 765             


Tyr Ala Glu Leu Glu Lys Leu Glu Arg Ile Pro Lys Asn His Glu His 
    770                 775                 780                 


Glu Phe Gly His His Lys Lys Phe Asn Ile Asn Arg Lys Glu Phe Asn 
785                 790                 795                 800 


Leu Phe Ser Lys Trp Leu Phe Ala Met Asp Glu Val Pro Glu Tyr Lys 
                805                 810                 815     


Asn Ser Leu Lys Glu Leu Leu Asp Asp Lys Asn Phe Phe Asp Asn Ser 
            820                 825                 830         


Glu Phe Gln Lys Leu Phe Glu Ser Ser Ser Asn Ile Asn Gln Phe Tyr 
        835                 840                 845             


Glu Ser Thr Lys Ser Lys Phe Lys Asn Trp Leu Asn Asp Gln Gln Val 
    850                 855                 860                 


Arg Asn Val Gly Lys Thr Ile Gln Pro Glu Asn Tyr Tyr Lys Met Met 
865                 870                 875                 880 


Glu Val Gly Asn Phe His Ile Asn Leu Ser His Leu Ile Ala Phe Gly 
                885                 890                 895     


Val Thr His Asn Phe Ile Glu Lys Ser Gly Lys Asn Ile Leu Arg Pro 
            900                 905                 910         


Ile Thr Ser His Ala Lys Tyr Leu Asn Thr Lys Ile Tyr Asp Ile Asp 
        915                 920                 925             


Leu Glu His Ser Asp Ala Ser Asn Leu Glu Lys Asn Ile Phe Arg Lys 
    930                 935                 940                 


Leu Tyr Lys Ile Arg Leu Glu Asp Cys Leu Leu Tyr Glu Ile Ala Leu 
945                 950                 955                 960 


Arg Tyr Phe Gln Pro Asn Leu Asn Leu Arg Gln Lys Ser Tyr Glu Gln 
                965                 970                 975     


Leu Asn Lys Leu Leu Val Gln Lys Ile Ser Ile Thr Ile Lys Ala Asn 
            980                 985                 990         


Asn Ser Gln Thr Tyr Gln Val Leu  Val Pro Phe Arg Asp  Leu Glu Lys 
        995                 1000                 1005             


Phe Glu  Gln Leu Lys Ala Ile  Asp Asp Asn Thr Gln  Asn Asn Phe 
    1010                 1015                 1020             


Ser Leu  Leu Arg Arg Leu Pro  Glu Tyr Leu Ser Gln  Leu Arg Lys 
    1025                 1030                 1035             


Arg Asn  Glu Asn Val Phe Gly  Leu Lys Asp Met Val  Lys Ala Phe 
    1040                 1045                 1050             


Gly Val  Asp Lys Ser Ile Ser  Leu Ala Asp Met Ser  Met Leu Tyr 
    1055                 1060                 1065             


Asn His  Leu Ile Thr Gln Gln  Gly Arg Tyr Thr Asn  Cys Ile Met 
    1070                 1075                 1080             


Ala Leu  Glu Glu Tyr Phe Ile  Trp Lys Glu Glu Cys  Thr Ile Glu 
    1085                 1090                 1095             


Gly Gln  Glu Asp Lys Lys Phe  Arg Leu 
    1100                 1105         


<210>  2342
<211>  1147
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2342

Met Asn Asn Asn Thr Ile Asp Glu Lys Thr Gly Ile Gly Leu Gly Lys 
1               5                   10                  15      


Thr Tyr Asn His Asp Lys Thr Glu Asp Lys His Tyr Phe Gly Gly Phe 
            20                  25                  30          


Phe Asn Leu Ala Asp Asp His Ile Glu Lys Ser Phe Lys Glu Ile Ser 
        35                  40                  45              


Glu Arg Leu Asn Leu Ser Asn Tyr Asp Lys Asn Asn Lys Ile Ser Phe 
    50                  55                  60                  


Leu Glu Val Ile Phe Lys Ile Asp Ala Leu Asp Ile Glu Trp Lys Arg 
65                  70                  75                  80  


Ala Val Gln Met Phe Ser Asn Tyr Phe Pro Phe Val Ser Val Ile Glu 
                85                  90                  95      


Lys Ile Thr Lys Met Glu Tyr Gln Asn Asp Asn Ile Lys Thr Ile His 
            100                 105                 110         


Ile Pro Thr Glu Asn Lys Lys Ala Ile Phe Ile Asn Thr Leu Val Ile 
        115                 120                 125             


Leu Phe Asp Ala Ile Glu Lys Leu Arg Asn Phe Tyr Thr His Tyr His 
    130                 135                 140                 


His Asn Asp Ile Val Leu Gly Glu Tyr Pro Ile Val Asn Thr His Ile 
145                 150                 155                 160 


Glu Asn Gln Ile Ser Val Leu Asp Tyr Gln Lys Ser Asn Phe Ile Ser 
                165                 170                 175     


Ser Asn Ile Phe Asn Ile Leu Asp Lys Ile Lys Leu Glu Ala Ile Gln 
            180                 185                 190         


Glu Val Lys Asn Lys Arg Met Asn Val Lys Asp Asn His Ser Leu Leu 
        195                 200                 205             


Asn Lys Lys Tyr Lys Asn Leu Phe Glu Asn Lys Asn Glu Glu Glu Thr 
    210                 215                 220                 


Lys Lys Leu Phe Asn Lys Ser Phe Lys Tyr Leu Tyr Glu Val Ile Lys 
225                 230                 235                 240 


Lys Gly Glu Asn Asn Tyr Glu Ala Ile Leu Lys Asp Phe His Arg Ser 
                245                 250                 255     


Lys Asn Thr Asn Ser Ile Thr Asn Asn Phe Lys Asn Asn Ile Ser Arg 
            260                 265                 270         


Ser Gly Phe Leu Phe Leu Phe Ser Leu Phe Leu Asp Lys Lys Glu Met 
        275                 280                 285             


Glu His Leu Leu Ser Lys Ser Lys Asn Phe Lys Ala Thr Asn Glu Leu 
    290                 295                 300                 


Gln Phe Leu Ala Thr Arg Trp Val Tyr Thr His Phe Cys Phe Lys Gly 
305                 310                 315                 320 


Leu Lys Asn Thr Ile Asn Thr Ser Phe Thr Lys Glu Thr Leu Leu Thr 
                325                 330                 335     


Gln Met Val Asp Tyr Leu Ser Lys Val Pro Asn Glu Ile Tyr Gln Tyr 
            340                 345                 350         


Leu Ser Glu Glu Asp Gln Glu Lys Phe Leu Glu Asp Glu Asn Glu Tyr 
        355                 360                 365             


Met Arg Asp Asn Glu Glu Asn Met Asp Ser Ser Glu Ser Ser Arg Val 
    370                 375                 380                 


Ile His Glu Val Lys Arg Lys Arg Tyr Glu Asn Lys Phe Asn Tyr Phe 
385                 390                 395                 400 


Ala Leu Arg Phe Ile Glu Glu Val Ile Gln Leu Pro Asn Leu Arg Phe 
                405                 410                 415     


Met Ile Lys Val Gly Ser Phe Val His Ser Gln Met Ser Lys Ser Val 
            420                 425                 430         


Gly Lys Gly Lys Asn Ile Leu Val Thr Asn Arg Val Ile Lys Glu Asp 
        435                 440                 445             


Ile Lys Val Phe Gly Arg Leu Asn Asp Val Ile Asp Ala Lys Asn Glu 
    450                 455                 460                 


Tyr Phe Asn Asn Lys Asn Asn Ile Pro Asn Ser Glu Leu Gly Tyr Trp 
465                 470                 475                 480 


Glu Glu Phe Pro Asn Pro Ser Tyr Tyr Phe Gln Gly Asn Asn Ile Pro 
                485                 490                 495     


Ile Tyr Ile Phe Asn Lys Ile Asp Glu Asn Thr Asn Gly Ile Glu Ala 
            500                 505                 510         


Ser Lys Arg Ile Asn Arg Ile Ser Lys Lys Asp Ile Leu Thr Lys Ile 
        515                 520                 525             


Ile Lys Glu Glu Asp Lys Asp Lys Phe Ile Phe Asp Lys Pro His Ala 
    530                 535                 540                 


Leu Leu Ser Cys Asn Glu Leu Ile Pro Leu Ile His Thr Tyr Leu His 
545                 550                 555                 560 


Lys Ala Asn Asn Thr Thr Asp Ile Glu Asn Leu Arg Leu Glu Ile Glu 
                565                 570                 575     


Lys Lys Ile Thr Ser Lys Ile Glu Asn Gln Lys Lys Thr Ile Glu Phe 
            580                 585                 590         


Phe Asn Pro Asp Lys Ala Ile Ser Ser Glu Asn Leu Lys Lys Tyr Pro 
        595                 600                 605             


Lys Lys Leu Phe Lys Thr Asn Ala Val Glu Thr Phe Leu Lys Val Lys 
    610                 615                 620                 


Asn Asn Asn Gly Asp Ile Val Phe Lys Ile Thr Asn Asp Ile Asp Glu 
625                 630                 635                 640 


Glu Ile Lys Lys Thr Gln Gln Lys Ile Phe Phe Leu Asn Asn Asn Thr 
                645                 650                 655     


Lys Glu Ile Gln Glu Gly Ile Arg Lys Tyr Leu Phe Thr Lys Lys Glu 
            660                 665                 670         


Ile Gly Lys Glu Ala Thr Trp Leu Ala Asn Asp Leu Lys Arg Met Met 
        675                 680                 685             


Pro Glu Ser Ser Arg Lys Asn Trp Lys Gly Tyr Glu His Gly Gln Leu 
    690                 695                 700                 


Gln Tyr Leu Phe Ser Phe Tyr Ser Glu Arg Lys Asn Glu Ile Arg Gln 
705                 710                 715                 720 


Leu Leu Asn Glu Lys Trp Lys Leu Phe Glu Asp Lys Phe Ile Gly Lys 
                725                 730                 735     


Thr Ile Ser Asp Ile Ile Glu Arg Arg Asn Asn Phe Asp Leu Phe Tyr 
            740                 745                 750         


Lys Asp Tyr Leu Ile Lys Arg Leu Glu Ile Leu Asn Asn Ile Lys Asn 
        755                 760                 765             


Asn Ile Thr Ile Asn Asn Glu Asn Leu Phe Arg Ile Phe Ser Lys Arg 
    770                 775                 780                 


Lys Tyr Val Thr Lys Asp Leu Glu Ser Tyr Lys Lys Ser Ile Ile Glu 
785                 790                 795                 800 


Gln Pro Val Asn Leu Pro Cys Gly Leu Phe Asp Ser Asn Pro Thr Phe 
                805                 810                 815     


Ile Ile Gly Lys Glu Trp Asn Asp Lys Asn Asn Glu Asn Lys Phe Ala 
            820                 825                 830         


Lys Trp Phe Thr Glu Ala Lys Lys Tyr Ser Ser Tyr Gln Ser Phe Tyr 
        835                 840                 845             


Thr Leu Pro Leu His Tyr Ile Glu Ile Asn Gln Lys Val Ile Tyr Lys 
    850                 855                 860                 


Asn Thr Arg Ser Ile Asn Lys Thr Lys Ile Gln Asp Tyr Tyr Leu Lys 
865                 870                 875                 880 


Asn Met Val Asp Asn Leu Tyr Asn Asp Leu Phe Asn Gln Lys Thr Ile 
                885                 890                 895     


Ser Leu Leu Glu Asp Tyr Tyr Val Ser Lys Glu Glu Arg Glu Gln Ile 
            900                 905                 910         


Lys Ser Ser Ala Lys Ile Asn His Glu Lys Asp Glu Ser Phe Ile Trp 
        915                 920                 925             


Lys Lys Gln Ile Asn Phe Glu Ala Tyr Asn Gly Arg Ile Lys Ser Lys 
    930                 935                 940                 


Ala Lys Met Lys Asp Phe Gly Lys Phe Lys Lys Ile Leu Leu Asn Ser 
945                 950                 955                 960 


Lys Ile Lys Asn Leu Ile Lys Tyr Asn Asn Gln Ser Trp Ser Ile Glu 
                965                 970                 975     


Leu Glu Asn Lys Gln Lys Tyr Cys Ser Leu Ser Met Glu Leu Glu Asn 
            980                 985                 990         


Tyr Glu Lys Ile Arg Ser Glu Tyr  Leu Leu Lys Gln Val  Gln Glu Leu 
        995                 1000                 1005             


Glu Glu  Ile Ile Leu Asn Asn  Asn Glu His Tyr Lys  Val His Lys 
    1010                 1015                 1020             


Ile His  Pro Ser Ile Phe Glu  Glu Lys Asn Gly His  Pro Asn Phe 
    1025                 1030                 1035             


Arg Phe  Tyr Ile Glu Thr Gly  Val Leu Glu Lys Ile  Ser Val Leu 
    1040                 1045                 1050             


Asn Leu  Gln Glu Phe Glu Lys  Leu Lys Lys Ile Asn  Leu His Ser 
    1055                 1060                 1065             


Leu Tyr  Glu Ser Glu Ile Ser  Glu Ile Gln Asn Leu  Thr Cys Pro 
    1070                 1075                 1080             


Trp Ile  Lys Lys Gly Leu Val  Val Ile Met Ile Arg  Asn Lys Phe 
    1085                 1090                 1095             


Ala His  Asn Gln Tyr Pro Asp  Lys Ile Ile Tyr Asp  Ile Thr Asn 
    1100                 1105                 1110             


Asn Asp  Ile Pro Lys Lys Glu  Asp Glu Tyr Phe Ala  Thr Tyr Phe 
    1115                 1120                 1125             


Asn Arg  Val Phe Glu Ser Tyr  Lys Thr Gln Leu Ile  Glu Lys Leu 
    1130                 1135                 1140             


Asn Asn  Lys Asn 
    1145         


<210>  2343
<211>  1133
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2343

Met Glu Glu Lys Leu Gly Lys Gly Val Glu Tyr Asn Pro Phe Lys Lys 
1               5                   10                  15      


Glu Asp Lys Tyr Tyr Phe Gly Gly Tyr Phe Asn Leu Ala Glu Asn Asn 
            20                  25                  30          


Ile Asn Glu Val Phe Lys Glu Val Lys Lys Arg Leu Gly Glu Thr Asn 
        35                  40                  45              


Ser Ser Ser Asn Ile Glu Leu Leu Asn Asn Val Phe Arg Lys Glu Met 
    50                  55                  60                  


Ser Leu Val Asp Tyr Glu Lys Trp Val Asn Ala Phe Ala Asp Tyr Phe 
65                  70                  75                  80  


Pro Ile Val Asn Tyr Leu Asp Arg Glu Thr Ile Lys Lys Gly Glu Lys 
                85                  90                  95      


Val Val Glu Val Pro Arg Glu Lys Arg Ile Glu Cys Phe Arg Asp Met 
            100                 105                 110         


Phe Lys Gly Leu Ile Asn Thr Ile Ser Gln Leu Arg His Tyr Tyr Thr 
        115                 120                 125             


His Tyr His His Glu Pro Ile Glu Ile Asp Asp Lys Ile Leu Ser Phe 
    130                 135                 140                 


Leu Asp Glu Val Leu Phe Asn Thr Ile Ile Thr Thr Lys Asn Lys Tyr 
145                 150                 155                 160 


Leu Lys Thr Asp Lys Thr Lys Glu Leu Ile Lys Asp Ser Leu Gln Glu 
                165                 170                 175     


Glu Leu Asp Ile Leu Cys Lys Leu Lys Val Lys Tyr Leu Glu Ser Lys 
            180                 185                 190         


Arg Lys Arg Phe Asp Arg Lys Asp Lys Gly Ala Ile Glu Asn Ala Val 
        195                 200                 205             


Tyr Asn Asp Val Phe Arg Arg Phe Ile Tyr Lys Asp Glu Lys Gly Asn 
    210                 215                 220                 


Glu Ser Leu Lys Asp Ile Ile Arg Thr Lys Gln Ile Lys Val His Gln 
225                 230                 235                 240 


Asn Ser Ser Tyr Leu Glu Leu Pro Ile Ser Ser Ser Gly Ile Ile Phe 
                245                 250                 255     


Leu Leu Ser Leu Phe Leu Asn Lys Lys Glu Val Glu Ser Leu Lys Ser 
            260                 265                 270         


Asn Ile Arg Gly Tyr Lys Gly Lys Ser Lys Ser Glu Glu Thr Thr Pro 
        275                 280                 285             


Glu Lys Asn Gly Leu Leu Phe Met Thr Thr His Arg Ile Tyr Ser Val 
    290                 295                 300                 


Leu Ala Tyr Lys Gly Leu Lys Lys Arg Ile Lys Thr Ser Val Lys Gly 
305                 310                 315                 320 


Asp Lys Glu Thr Leu Leu Met Gln Met Ile Asp Glu Val Ser Lys Val 
                325                 330                 335     


Pro His Cys Ile Tyr Gln Asn Leu Asp Gln Thr Leu Gln Ala Thr Phe 
            340                 345                 350         


Ile Glu Asp Trp Asn Glu Tyr Phe Lys Asp Asn Glu Glu Asn Glu Glu 
        355                 360                 365             


Asn Leu Glu Asn Ser Arg Val Leu His Pro Val Ile Arg Lys Arg Tyr 
    370                 375                 380                 


Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Tyr Ala 
385                 390                 395                 400 


Glu Phe Pro Ser Leu Arg Phe Gln Val Asn Leu Gly Asn Tyr Val His 
                405                 410                 415     


His Lys Ala Thr Lys Lys Phe Gly Asn Ser Glu Val Thr Thr Glu Arg 
            420                 425                 430         


Val Ile Lys Asp Lys Ile Thr Val Phe Gly Arg Leu Ser Glu Val Asn 
        435                 440                 445             


Lys Ala Lys Ala Asp Phe Phe Lys Asn Glu Thr Glu Leu Asp Pro Ala 
    450                 455                 460                 


Trp Glu Leu Phe Pro Asn Pro Ser Tyr Glu Phe Pro Lys Glu Lys Gly 
465                 470                 475                 480 


Asn Asn Asp Lys Asp Ala Gly Lys Ile Gly Ile Gln Val Lys Leu Leu 
                485                 490                 495     


Asn Lys Asp Ile Glu Ala Val Leu Asn Glu Ser Lys Asn Thr Leu Asn 
            500                 505                 510         


Asn Lys Thr Arg Lys Ser Asp Lys Ile Ser Lys Lys Glu Ile Ile Asn 
        515                 520                 525             


Lys Ile Val Gln Ile Asn Asp Asp Thr Lys Tyr Asn Asn Lys Asn Ile 
    530                 535                 540                 


Ile Tyr Gln Gly Asn Ala Ile Ala Tyr Leu Ser Leu Asn Asp Ile His 
545                 550                 555                 560 


Ser Leu Leu Tyr Glu Leu Leu Val Ile Gly Thr Lys Gly Asp Lys Leu 
                565                 570                 575     


Glu Arg Lys Val Val Glu Lys Ile Gln Gln Gln Val Thr Glu Ile Arg 
            580                 585                 590         


Asn Lys Asp Thr Ser Ala Lys Ile Leu Ser Lys Tyr Lys Asp Ser Glu 
        595                 600                 605             


Glu Ser Asn Thr Ile Asp Lys Lys Lys Leu Val Ile Asp Leu Lys Tyr 
    610                 615                 620                 


Glu Tyr Asp Lys Leu Gln Asp Leu Leu Lys Glu His Lys Asn Arg Glu 
625                 630                 635                 640 


Glu Asp Tyr Ile Gln Thr Lys Lys Lys Lys Lys Asp Ser Pro Lys Arg 
                645                 650                 655     


Lys Tyr Ile Leu Tyr His Asn Glu Lys Gly Gln Val Ala Val Trp Leu 
            660                 665                 670         


Ser Asn Asp Ile Lys Arg Phe Met Pro Gln Asn Phe Lys Glu Lys Trp 
        675                 680                 685             


Lys Gly Tyr Gln His Ser Glu Phe Gln Lys Ser Leu Ala Tyr Tyr Glu 
    690                 695                 700                 


Thr Asn Lys Glu Met Leu Lys Ile Ile Leu Gln Asp Leu Asp Leu Glu 
705                 710                 715                 720 


Gln Phe Pro Phe Asp Ile Lys Ser Cys Phe Tyr Lys Asn Thr Leu Glu 
                725                 730                 735     


Asp Phe Tyr Asn Arg Tyr Leu Ser Leu Arg Ile Ser Tyr Leu Glu Asn 
            740                 745                 750         


Val Ile Asp Arg Val Glu Cys Phe Ser Asn Glu Pro Lys Ala Phe Lys 
        755                 760                 765             


Ser Val Leu Lys Glu Cys Phe Val Phe Leu Lys Lys Gln Asn Tyr Thr 
    770                 775                 780                 


Asn His Ser Leu Asp Glu Gln Val Lys Lys Ile Leu Ala Asn Pro Ile 
785                 790                 795                 800 


Phe Ile Glu Arg Gly Phe Leu Asp Thr Lys Pro Thr Met Ile Gln Gly 
                805                 810                 815     


Val Lys Phe Ser Glu Asn Lys Gly Cys Phe Ala Asp Trp Phe Val His 
            820                 825                 830         


Tyr Lys Glu Tyr Glu His Tyr Gln Lys Phe Tyr Asp Thr Asn Leu Tyr 
        835                 840                 845             


Pro Val Glu Ser Ile Glu Asp Lys Glu Arg Gln Lys Leu Glu Ala Thr 
    850                 855                 860                 


Ile Lys Lys Gln Gln Lys Asn Asp Val Phe Thr Leu Leu Met Ile Lys 
865                 870                 875                 880 


Lys Ile Phe Asn Asp Leu Phe Asn Gln Asp Phe Glu Ala Asn Leu Tyr 
                885                 890                 895     


Glu Met Tyr Gln Ser Lys Glu Glu Arg Glu Lys Asn Gln Leu Val Ala 
            900                 905                 910         


Lys Glu Thr Gln Asn Arg Asn Leu Asn Phe Ile Trp Asn Lys Pro Ile 
        915                 920                 925             


Ala Ile Asp Leu Phe Asp Gly Lys Val Lys Ile Asp Glu Val Lys Leu 
    930                 935                 940                 


Lys Asp Val Gly Ser Phe Arg Lys Tyr Glu Asn Asp Lys Arg Val Gln 
945                 950                 955                 960 


Thr Phe Ile Thr Tyr Ile Pro Glu Ile Gln Trp Ile Pro Tyr Leu Pro 
                965                 970                 975     


Asn Thr Trp Glu Gly Ile Asn Leu Pro Val Asn Val Ile Glu Arg Gln 
            980                 985                 990         


Ile Asp Arg Tyr Glu Lys Val Arg  Ser Glu Glu Leu Leu  Lys Glu Val 
        995                 1000                 1005             


Gln Ala  Ile Glu Lys Tyr Ile  Tyr Glu Gln Val Asn  Asp Lys Thr 
    1010                 1015                 1020             


Glu Leu  Leu Gln Asn Gly Asn  Gln Asn Phe Lys Asn  Tyr Leu Val 
    1025                 1030                 1035             


Asn Gly  Leu Leu Lys Gln Ile  Gln Gly Ile Asp Val  Ser Asn Phe 
    1040                 1045                 1050             


Lys Phe  Ile Asn Gln Gln Lys  Phe Glu Thr Ile Asn  Val Lys Asp 
    1055                 1060                 1065             


Leu Asp  Asn Glu Ala Ser Ala  Leu Glu Gln Lys Val  Tyr Val Leu 
    1070                 1075                 1080             


Ile Asn  Ile Arg Asn Gln Phe  Ser His Asn Gln Phe  Pro Lys Ser 
    1085                 1090                 1095             


Ala Phe  Tyr Gln Phe Cys Gln  Lys Ile Leu Ser Ile  Glu Glu Asp 
    1100                 1105                 1110             


Glu Leu  Phe Ala Asp Tyr Tyr  Leu Arg Leu Phe Lys  Leu Leu Arg 
    1115                 1120                 1125             


Asn Glu  Leu Leu Asp 
    1130             


<210>  2344
<211>  1058
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2344

Met Asn Asn Pro Glu Asn Gln Lys Glu Lys Thr Ser Ile Gly Thr His 
1               5                   10                  15      


Pro Phe Tyr Phe Gly His Tyr Leu Asn Met Ala Arg His Asn Ala Tyr 
            20                  25                  30          


Ile Ile Leu Cys Ala Leu Ser Lys Lys Tyr Asn Phe Asn Ile Pro Asp 
        35                  40                  45              


Glu Ser Glu Gln Asn Glu Ala Gln Leu Asn His Phe Lys Ile Leu Asn 
    50                  55                  60                  


Phe Ala Ala Asp Lys Glu Lys Arg Pro Asp Glu Leu Asn Ala Ile Lys 
65                  70                  75                  80  


Glu Asp Leu Gln Phe His Phe Pro Val Leu Lys Ala Phe Gln Leu Ser 
                85                  90                  95      


Glu Phe Gly Lys Ser Phe Ser Asp Leu Leu Ile Leu Leu Gly Asp Leu 
            100                 105                 110         


Arg Asn Arg Tyr Ser His Val Tyr Tyr Lys Lys Asp Phe Lys His Glu 
        115                 120                 125             


Val Glu Leu Arg Asp Ile Leu Lys Gln Ala Arg Lys Asp Ala Ile Lys 
    130                 135                 140                 


Arg Met Asn Ser Val Ile Pro Glu Glu Glu Phe His His Leu Val Lys 
145                 150                 155                 160 


Val Lys Glu Ser Lys Ile Pro Phe Lys Phe Tyr Leu Thr Glu Arg Asp 
                165                 170                 175     


Arg Asn Thr Leu Thr Glu Lys Gly Val Ala Phe Leu Cys Cys Leu Phe 
            180                 185                 190         


Leu Glu Lys Lys Phe Ala Phe Arg Phe Leu Ser Arg Leu Glu Asn Phe 
        195                 200                 205             


His Arg Thr Glu Glu Lys Trp Ala Arg Ala Thr Leu Glu Thr Phe Thr 
    210                 215                 220                 


Glu Tyr Cys Cys Ile Leu Pro Tyr Asp Arg Leu Asp Ser Ser Asp Ile 
225                 230                 235                 240 


Lys Leu Asp Met Ile Asn Glu Leu Asn Arg Cys Pro Arg Glu Leu Tyr 
                245                 250                 255     


Tyr Leu Leu Asp Asp Ser Leu Lys Lys Lys Phe Leu Asp Lys Pro Glu 
            260                 265                 270         


Ala Glu Glu Asp Leu Thr Glu Thr Ser Thr Asp Glu Asn Ala Glu Tyr 
        275                 280                 285             


Glu Lys Pro Thr Pro Leu Arg Arg His Ser Asp Arg Phe Pro Trp Phe 
    290                 295                 300                 


Ala Leu Asn Phe Phe Glu Asn Val Tyr Pro Gly Ile His Phe Gln Val 
305                 310                 315                 320 


Lys Leu Gly Arg Val Leu Thr Gln Asp Leu Tyr Asp Lys Thr Ile Ala 
                325                 330                 335     


Ser Thr Ser Arg Asp Arg Arg Ile Leu Lys Asp Ile Asn Ser Leu Gly 
            340                 345                 350         


His Pro Phe Lys Tyr Pro Val Glu Ser Ala Pro Asp Ser Trp Tyr Asn 
        355                 360                 365             


Ile Lys Gln Ala Ser Glu Thr Gly Leu Val Asn Thr Ala Met Arg Ala 
    370                 375                 380                 


Gly Glu Ile Asp Gln Tyr Ser Pro Lys Phe Arg Ile Thr Glu Lys Arg 
385                 390                 395                 400 


Ile Gly Leu Phe Leu Asn Lys Pro Tyr Thr Ile Pro Phe Trp Pro Asn 
                405                 410                 415     


Leu Ser Lys Glu Ala Lys Pro Lys Lys Ser Gly Pro Ile Ile Thr Thr 
            420                 425                 430         


Cys Lys Ala Ser Ala Ile Lys Pro Asp Ala Ile Leu Ser Thr Tyr Glu 
        435                 440                 445             


Leu Gln Asn Leu Phe Leu Tyr Thr Tyr Leu Tyr Lys Glu Glu Asn Arg 
    450                 455                 460                 


Ile Ser Lys Ser Pro Glu Gln Phe Ile Leu Asp Phe Gln Arg Glu Phe 
465                 470                 475                 480 


Asn Arg Phe Leu Ser Asp Leu Ser Ala Gly Lys Leu His Pro Val Ser 
                485                 490                 495     


Asp Gln Leu Leu Leu Lys Gln Pro Gly Arg Asp Ile Glu Asp Pro Asp 
            500                 505                 510         


Trp Lys Glu Arg Lys Ala Arg Leu Ser Asp Leu Leu Gln Pro Tyr Gly 
        515                 520                 525             


Leu Lys Asp Ser Tyr Leu Pro Asp Asp Ile Lys Asn Tyr Leu Leu Gly 
    530                 535                 540                 


Val Ala Asp Pro Glu Leu Lys Lys Arg Val Leu Ala Lys Ile Asp Thr 
545                 550                 555                 560 


Gln Ile Lys Thr Thr Lys Asp Tyr Ile Glu Tyr Val Gly Lys Arg Leu 
                565                 570                 575     


Asp Lys Ser Thr Lys Asn Thr Val Arg Val Ile Pro Val Gly Lys Met 
            580                 585                 590         


Ala Gln Ile Leu Ala Arg Asp Ile Val Phe Met Leu Pro His Val Asp 
        595                 600                 605             


Lys Val Ser Lys Pro Asn Asn Gln Gln Tyr Tyr Val Leu Gln Asn Met 
    610                 615                 620                 


Leu Ala Tyr Phe Ser Leu Lys Lys Lys Glu Leu Arg Asp Leu Phe Lys 
625                 630                 635                 640 


Glu Leu His Leu Thr Gln Ala Asp Arg His Pro Phe Leu His Lys Ile 
                645                 650                 655     


Asn Leu Glu Glu Ser Lys Gly Ile Leu Glu Phe Phe Gly Asn Tyr Phe 
            660                 665                 670         


Lys Leu Lys Asn Glu Tyr Leu Asn Gly Leu Arg Ile Gly Leu Asp Ser 
        675                 680                 685             


Val Asn Phe Lys Arg Phe Tyr Lys Glu Asn Lys His Leu Phe Asp Ala 
    690                 695                 700                 


Glu Lys Lys Asp Val Trp Lys Arg Asn Tyr Ser Glu Thr His Leu Leu 
705                 710                 715                 720 


Pro Arg Gly Leu Phe Asn Gln Ala Ile Ala Arg Ala Leu Asn Ala Asp 
                725                 730                 735     


Glu Lys Glu Gly Val Asp Lys Trp Leu Ser Met Leu Pro Gly Leu Gly 
            740                 745                 750         


Thr Val Thr Gln Asn Tyr Tyr Thr His Lys Arg Tyr Tyr Leu Lys Asn 
        755                 760                 765             


Arg Ser Glu Glu Phe Lys Ala Leu Asn Asp Thr Gly Asn Pro Tyr Asp 
    770                 775                 780                 


Leu Ile Gly Gln Ile Asn Thr Leu Leu Gln Ser Lys Gln Lys Pro Glu 
785                 790                 795                 800 


Asp Ser Lys Arg Leu Arg Asp Leu Lys Lys Glu Ile Leu Asp Thr Glu 
                805                 810                 815     


Lys Thr Ile Arg Tyr Arg Gln Ser Thr Asp Arg Ala Leu Trp Leu Met 
            820                 825                 830         


Leu His Tyr Met Phe Thr His Asp Glu Arg Thr Lys Glu Thr Thr Thr 
        835                 840                 845             


Leu Asn Phe Glu Leu Asn Lys Leu Gln Tyr Ile Gly Tyr Asp Asn Glu 
    850                 855                 860                 


Glu Phe Ser Leu Phe Ser Asp Glu Tyr Pro Phe Thr Tyr Glu Ile Glu 
865                 870                 875                 880 


Asn Lys Glu His Arg Arg Lys Leu Lys Val Thr Glu Thr Met His Ile 
                885                 890                 895     


Arg Arg Tyr Gly Asp Phe Arg Arg Phe Phe Lys Asp Arg Arg Leu Lys 
            900                 905                 910         


Asp Leu Ile Leu Tyr Phe Pro Glu Glu Glu Gln Ser Ile Asp Arg Gly 
        915                 920                 925             


Lys Leu Ile Lys Glu Leu Asp Thr Tyr Glu Glu Lys Arg Glu Lys Leu 
    930                 935                 940                 


Phe Glu Lys Phe Tyr Gln Phe Glu Lys Leu Leu Asn Glu Lys Tyr Gly 
945                 950                 955                 960 


Asp Gln Ile Ser Pro Lys Ile Lys Gly Lys Ala Glu Tyr Lys Asp His 
                965                 970                 975     


Thr Val Tyr Leu Asp Phe Ile Arg Gln Lys Pro Ala Leu Leu Glu Asn 
            980                 985                 990         


Val Arg Phe Leu Asn Asp Glu Lys  Phe Ser Glu Leu Arg  Asn Lys Ile 
        995                 1000                 1005             


Leu His  Asn Gln Ile Pro Val  Phe Glu Trp Val Arg  Glu Glu Val 
    1010                 1015                 1020             


Leu Arg  Gly Asp Ile Arg Lys  Thr His Thr Glu Arg  Ile Leu Asp 
    1025                 1030                 1035             


Ile Ile  Gly Asp Val Tyr Asp  Thr Met Ile Glu Asn  Ile His Lys 
    1040                 1045                 1050             


Glu Glu  Thr Asn Ser 
    1055             


<210>  2345
<211>  1107
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2345

Met Ser Thr Arg Tyr Thr Asn Gln Lys Lys Val Glu Glu Asn Ile Asn 
1               5                   10                  15      


Tyr Val Phe Ser Asn Lys Gly Ile Phe Ala Ala Val Ala Glu Lys Thr 
            20                  25                  30          


Leu Thr Asn Tyr Lys Ser Lys Phe Asn Glu Gly Gln Thr Ile Gln Pro 
        35                  40                  45              


Asn Leu His Tyr Phe Ala Val Gly His Thr Phe Lys Asn Ile Asp Thr 
    50                  55                  60                  


Lys Arg Ile Phe Asp Tyr Gln Leu Ser Glu Asp Glu Met Asp Ile Leu 
65                  70                  75                  80  


Pro Thr Lys Tyr Phe Ser Leu Gln Gln Asn Lys Phe Ser Phe Pro Ile 
                85                  90                  95      


Asp Gly Gln Thr Lys Thr Asp Lys Leu Tyr Leu Leu Leu Asp Asn Ile 
            100                 105                 110         


Arg Asn Ile Asn Ala His Phe Ile His Asp Phe Asn Phe Leu Lys Val 
        115                 120                 125             


Asp Asn Ile Asp Glu Asn Ile Ile Cys Phe Leu Ile Asp Ser Phe Glu 
    130                 135                 140                 


Leu Ala Leu Ile Lys Gly Val Phe Ala Lys Lys Tyr Gly Asp Lys Lys 
145                 150                 155                 160 


Ser Lys Leu Arg Leu Asp Phe Leu Ser Asn Glu Ala Arg Asp Glu Ile 
                165                 170                 175     


Leu Thr Asp Ile Leu Glu Asn Leu Asp Lys Glu Leu Ile Val Phe Met 
            180                 185                 190         


Lys Glu Ile Phe Tyr Gln Thr Leu Tyr Val Val Asp Lys Lys Glu Trp 
        195                 200                 205             


Arg Asn Lys Glu Leu Asn Gln Glu Lys Lys Asp Phe Leu Asp Asn His 
    210                 215                 220                 


Leu Ser Ser Lys Glu Asp Trp Ile Asn Trp Ile Leu Phe Asn Cys Val 
225                 230                 235                 240 


Glu Glu Asp Ile Asp Trp Tyr Leu Asn Asn Tyr Gly Asp Tyr Asp Pro 
                245                 250                 255     


His Pro Asp Ser Lys Asn His Lys His Lys Val Leu Thr Ile Glu Lys 
            260                 265                 270         


Gly Lys Tyr Leu Ser Phe Glu Gly Ser Leu Phe Met Met Thr Met Phe 
        275                 280                 285             


Leu Tyr Ala Asn Glu Ala Asn Tyr Leu Ile Pro Lys Leu Lys Gly Tyr 
    290                 295                 300                 


Lys Lys Asn Gly Thr Pro Gln Asp Ala Ser Lys Leu Glu Val Phe Arg 
305                 310                 315                 320 


Phe Phe Ala Lys Lys Phe Lys Ser Gln Asp Val Asp Ser Glu His Lys 
                325                 330                 335     


Gln Tyr Val Lys Phe Arg Asp Met Ile Gln Tyr Val Gly Lys Tyr Pro 
            340                 345                 350         


Thr Val Trp Asn Lys His Ile His Leu Asp Ser Tyr Tyr Val Lys Asp 
        355                 360                 365             


Leu Lys Ala Thr Ile Leu Glu Asn Glu Ile Ile Gln Leu Tyr Gln Glu 
    370                 375                 380                 


Asp Ile Lys Asn His Phe Gln Ser Ile Cys Gly Leu Lys Gln Phe Glu 
385                 390                 395                 400 


Asp Ser Gln Glu Glu Ile Gln Leu Ala Phe Ile Glu Val Ala Lys Asp 
                405                 410                 415     


Tyr Leu Gln Asn Lys Glu Ile Tyr Tyr Thr Gly Glu Tyr Arg Glu Asp 
            420                 425                 430         


Cys Ile Thr Ile Leu Lys Thr Ser Ala Glu His Leu Ala Asn Lys Arg 
        435                 440                 445             


Gln Leu Lys Asp Ile Gln Lys Gln Leu Lys Lys Tyr Ile Asn Lys Ala 
    450                 455                 460                 


Tyr Lys Ser Leu Ser Ser Glu Asp Gln Gly Lys Lys Lys Lys Leu Asp 
465                 470                 475                 480 


Ile Ser Lys Leu Lys Tyr Ile Asp Lys Ile Arg Lys Ser Lys Asn Ser 
                485                 490                 495     


Ile Asn Thr Thr Thr Asp Lys Phe Ala Lys Arg Val Glu Asp Asn Leu 
            500                 505                 510         


Leu Phe Ile Ser Asn Gly Arg Asn Ser Asp Arg Phe Met Val Phe Ala 
        515                 520                 525             


Cys Arg Phe Leu Ala Glu Ile Asn Tyr Phe Gly Lys Asp Ala Gln Phe 
    530                 535                 540                 


Lys Met Tyr Glu Asn Tyr Tyr Ser Glu Glu Glu Gln Asn Ala Leu Lys 
545                 550                 555                 560 


Asp Lys Lys Gln Asn Leu Thr Gln Lys Glu Phe Asp Lys Leu His Tyr 
                565                 570                 575     


His Gly Gly Lys Leu Thr His Phe Glu Thr Phe Glu Asn His Thr Lys 
            580                 585                 590         


Lys Tyr Pro Asn Trp Asp Met Pro Phe Val Val Gln Asn Asn Ala Ile 
        595                 600                 605             


Tyr Val Lys Ile Pro Gly Ile Asn Phe Ile Lys Asn Thr Ala Phe Cys 
    610                 615                 620                 


Ile Gln Arg Asn Val Ile Asn Tyr Leu Leu Glu His Ala Leu Gly Glu 
625                 630                 635                 640 


Asn Tyr Lys Asp Gln Gln Gly Arg Lys Trp Leu Phe Asp Tyr Tyr Glu 
                645                 650                 655     


His Lys Thr Glu Ala Thr Asp Asn Ala Lys Arg Ile Leu Thr Glu Ser 
            660                 665                 670         


Lys Pro Ile Glu Ala Ser Ser Lys Thr Lys Leu Lys Lys Leu Leu Pro 
        675                 680                 685             


Lys Lys Leu Phe Pro Lys Tyr Ser Ala Ser Glu Thr Glu Lys Asn Ile 
    690                 695                 700                 


Leu Arg Lys Tyr Leu Glu Gln Ala Glu Glu Ser Glu Lys Leu Tyr Glu 
705                 710                 715                 720 


Asn Gln Lys Asp Lys Ala Lys Ala Glu Asn Arg Leu Asp Leu Phe Val 
                725                 730                 735     


Asn Lys Asn Lys Gly Lys Gln Phe Lys Leu Arg Phe Ile Phe Lys Ala 
            740                 745                 750         


Trp Gln Leu Met Tyr Phe Lys Lys Gln Tyr Gln Ile Glu Lys Glu Arg 
        755                 760                 765             


Tyr Ala Glu Leu Glu Lys Leu Glu Arg Ile Pro Lys Asn His Glu His 
    770                 775                 780                 


Glu Phe Gly His His Lys Lys Phe Asn Ile Asn Arg Lys Glu Phe Asn 
785                 790                 795                 800 


Leu Phe Ser Lys Trp Leu Phe Ala Met Asp Glu Val Pro Glu Tyr Lys 
                805                 810                 815     


Asn Ser Leu Lys Glu Leu Leu Asp Asp Lys Asn Phe Phe Asp Asn Ser 
            820                 825                 830         


Glu Phe Gln Lys Leu Phe Glu Ser Ser Ser Asn Ile Asn Gln Phe Tyr 
        835                 840                 845             


Glu Ser Thr Lys Ser Lys Phe Lys Asn Trp Leu Asn Asp Gln Gln Val 
    850                 855                 860                 


Arg Asn Val Gly Lys Thr Ile Gln Pro Glu Asn Tyr Tyr Lys Met Met 
865                 870                 875                 880 


Glu Val Gly Asn Phe His Ile Asn Leu Ser His Leu Ile Ala Phe Gly 
                885                 890                 895     


Val Thr His Asn Phe Ile Glu Lys Ser Gly Lys Asn Ile Leu Arg Pro 
            900                 905                 910         


Ile Thr Ser His Ala Lys Tyr Leu Asn Thr Lys Ile Tyr Asp Ile Asp 
        915                 920                 925             


Leu Glu His Ser Asp Ala Ser Asn Leu Glu Lys Asn Ile Phe Arg Lys 
    930                 935                 940                 


Leu Tyr Lys Ile Arg Leu Glu Asp Cys Leu Leu Tyr Glu Ile Ala Leu 
945                 950                 955                 960 


Arg Tyr Phe Gln Pro Asn Leu Asn Leu Arg Gln Lys Ser Tyr Glu Gln 
                965                 970                 975     


Leu Asn Lys Leu Leu Val Gln Lys Ile Ser Ile Thr Ile Lys Ala Asn 
            980                 985                 990         


Asn Ser Gln Thr Tyr Gln Val Leu  Val Pro Phe Arg Asp  Leu Glu Lys 
        995                 1000                 1005             


Phe Glu  Gln Leu Lys Ala Ile  Asp Asp Asn Thr Gln  Asn Asn Phe 
    1010                 1015                 1020             


Ser Leu  Leu Arg Arg Leu Pro  Glu Tyr Leu Ser Gln  Leu Arg Lys 
    1025                 1030                 1035             


Arg Asn  Glu Asn Val Phe Gly  Leu Lys Asp Met Val  Lys Ala Phe 
    1040                 1045                 1050             


Gly Val  Asp Lys Ser Ile Ser  Leu Ala Asp Met Ser  Met Leu Tyr 
    1055                 1060                 1065             


Asn His  Leu Ile Thr Gln Gln  Gly Arg Tyr Thr Asn  Cys Ile Met 
    1070                 1075                 1080             


Ala Leu  Glu Glu Tyr Phe Ile  Trp Lys Glu Glu Cys  Thr Ile Glu 
    1085                 1090                 1095             


Gly Gln  Glu Asp Lys Lys Phe  Arg Leu 
    1100                 1105         


<210>  2346
<211>  1087
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2346

Met Lys Asn Ile Tyr Lys Glu Gly Arg Pro Val Met Ala Ala Tyr Phe 
1               5                   10                  15      


Asn Met Ala Leu Arg Asn Leu Arg Asn Val Val Ile Asp Ile Gln Lys 
            20                  25                  30          


Lys Val Glu Lys Gly Asp Pro Asn Ile Asn Asp Gly Glu Leu Leu Lys 
        35                  40                  45              


Ala Ser Val Ile Lys Arg Leu Ala Arg His Ile Glu Gly Lys Arg Thr 
    50                  55                  60                  


Ile Ser Pro Tyr Gln Pro Glu Leu Leu Asp Met Ala Ile Lys Met Phe 
65                  70                  75                  80  


Phe Gln Lys Ile Lys Phe Leu Ala Pro Leu Arg Glu Ala Ile Ser Leu 
                85                  90                  95      


Lys Asp Gly Ile Thr Glu Ala Glu Trp Leu Lys Thr Asn Phe Ser Glu 
            100                 105                 110         


Ile Tyr Thr Ile Leu Leu Lys Tyr Arg Asn Leu Phe Thr His Tyr Asp 
        115                 120                 125             


Pro Lys Asn Ser Leu Asp Glu Ile Gln Ser Tyr Glu Trp Lys Ala Val 
    130                 135                 140                 


Trp Leu Leu Gln Lys Cys Ile Glu Gly Gly Arg Arg Glu Val Lys Thr 
145                 150                 155                 160 


Arg Phe Asn Phe Ser Glu Gln Asp Met Ala Phe Leu Thr Gly His Asp 
                165                 170                 175     


Ile Gly Glu Ala Lys Gln Arg Glu Pro Ile Asp Glu Gln Gly His Asn 
            180                 185                 190         


Gln Tyr Gly Asn Arg Arg Arg Ser Ala Phe Lys Phe Ile Asp Arg Glu 
        195                 200                 205             


Asp Phe Arg Tyr Asn Val Arg Lys Asn Lys Phe Asp Gly Gln Asn Arg 
    210                 215                 220                 


Thr Thr His Leu Ser Asp Val Gly Ile Val Met Phe Cys Cys Leu Phe 
225                 230                 235                 240 


Leu Glu Arg Lys Tyr Ile Ser Glu Phe Thr Gln Gln Ile Gly Leu Phe 
                245                 250                 255     


Asn Ile Gln Phe Gln Ser Gly Lys Asn Arg Ile Leu Lys Arg Pro Asp 
            260                 265                 270         


Asp Lys Glu Lys Lys Ile Met Arg Glu Ile Leu Ala Tyr Tyr Arg Ile 
        275                 280                 285             


Leu Thr Pro Arg Pro Arg Val Glu Ser Thr Arg Pro Glu Tyr Ala Leu 
    290                 295                 300                 


Ala Leu Asp Ile Phe Asn Glu Leu Gln Lys Ala Pro Ile Glu Leu Phe 
305                 310                 315                 320 


Asp Thr Phe Ser Pro Asp Asp Gln Ala Lys Phe Arg Ile Val Gly Asp 
                325                 330                 335     


Asn Asp Ser Glu Thr Leu Met Val Arg His Arg Asp Arg Phe Pro Tyr 
            340                 345                 350         


Phe Val Met Arg Tyr Ile Asp Asp Asn Arg Ile Phe Thr Lys Ile Arg 
        355                 360                 365             


Phe Gln Met Ser Leu Gly Lys Tyr Arg Phe Lys Phe Tyr Glu Lys Gln 
    370                 375                 380                 


Cys Ile Asp Ser Ser Asp Lys Asp Arg Ile Arg Ser Leu Gln Lys Glu 
385                 390                 395                 400 


Val Asn Gly Phe Gly Arg Phe Asp Glu Ile Glu Gln Phe Arg Lys Glu 
                405                 410                 415     


Arg Tyr Ala His Leu Leu Thr Gln Ser Asp Ile Pro Glu Ala Asp Thr 
            420                 425                 430         


Ile Asp Ser Lys Pro Tyr Leu Thr Asn Gln Gln Ala Ser Tyr Leu Tyr 
        435                 440                 445             


Asn Gly Asn Arg Ile Gly Leu Trp Trp Gly Asp Asn Cys Phe Leu Pro 
    450                 455                 460                 


Glu Ile Thr Ala Asp Lys Ala Glu Cys Arg Gln Pro Leu Ala Trp Leu 
465                 470                 475                 480 


Ser Phe His Glu Met Pro Ala Met Met Phe His Tyr Ile Leu Ser Asn 
                485                 490                 495     


Ser Gly Phe Gln Thr Gln Glu Ile Ile Ile Asn Tyr Val Lys Asn Leu 
            500                 505                 510         


Lys Asp Phe Phe Leu Lys Ile Ala Asp Gly Thr Ile Thr Pro Asp Asn 
        515                 520                 525             


Tyr Ser Asp Tyr Leu Thr Asp Asp Ile Thr Ile Asn Arg Leu Pro Glu 
    530                 535                 540                 


Lys Ile Arg Glu Tyr Leu Leu Gly Asn Val Pro Val Val Asp Glu Asp 
545                 550                 555                 560 


Ser Leu Val Asn Asp Ile Asn Asp Lys Tyr Glu Lys Met Val Glu Glu 
                565                 570                 575     


Ala Lys Ile Leu Leu Lys Arg Phe Asp Asp Asp Cys Lys Arg Ala Asn 
            580                 585                 590         


Ala Thr Asp Asn Lys Phe Gly Lys Lys Ser Phe Val Thr Ile Lys Pro 
        595                 600                 605             


Gly Arg Leu Ala Ser Trp Leu Ala Lys Asp Ile Val Ala Leu Gln Phe 
    610                 615                 620                 


Ser Asn Glu Lys Gly Asp Asn Lys Leu Thr Gly Leu Asn Tyr Gln Val 
625                 630                 635                 640 


Met Gln Ser Ala Ile Ala Gln Trp Glu Ser Ala Asp Ala Val Arg Arg 
                645                 650                 655     


Ile Phe Glu Asn Ala Asn Leu Leu Ser Gly Asp Tyr Ser His Pro Phe 
            660                 665                 670         


Leu Ala Lys Ala Met Ala Gly Asn Pro Lys Ser Thr Ala Glu Phe Tyr 
        675                 680                 685             


Arg Ala Tyr Leu Lys Gln Arg Ser Arg Lys Asp Trp Glu Val Thr Phe 
    690                 695                 700                 


Phe Arg Pro Asn Arg Leu Arg Asn Gln Glu Arg Thr Pro Glu Trp Tyr 
705                 710                 715                 720 


Lys Cys Leu Ala Thr Arg Tyr Ala Glu Gln Pro Ile Asp Leu Pro Arg 
                725                 730                 735     


Ser Leu Phe Asp Asn Ala Ile Arg Arg Cys Leu Val Asn Asn His Ile 
            740                 745                 750         


Asp Ile Pro Lys Arg Ala Asn Val Ala Phe Leu Ile Lys Arg Tyr Leu 
        755                 760                 765             


Ser Val Glu Met Ala Asp Ala Asn Gln Leu Phe Tyr Asp Ser Gln Lys 
    770                 775                 780                 


Tyr Arg Arg Ser Tyr Lys Leu Phe Asn Ile Leu Phe Gly His Arg Glu 
785                 790                 795                 800 


Arg Asn Lys Ile Leu Pro Asn Tyr Tyr Ser Ile Asp Glu Met Ile Lys 
                805                 810                 815     


Leu Val Gly Glu Lys Gly Val Ser Leu Arg Lys Ser Ile Glu Asn His 
            820                 825                 830         


Leu Lys Gln Phe Gly Asn Ile Gln Lys Phe Gly Gln Asn Lys Ala Asp 
        835                 840                 845             


Asp Ile Ile Asn Asp Glu Arg Gln Lys Ile Gln His Ala Lys Ser Phe 
    850                 855                 860                 


Tyr Cys Asp Asn Glu Lys Gln Ile Arg Arg Phe Met Thr Gln Asp Ile 
865                 870                 875                 880 


Ile Leu Tyr Ile Leu Ala Arg Lys Val Ile Ile Ser Gln Pro Gln Phe 
                885                 890                 895     


Ala Ile Ser Glu Ala Asn Ile Phe Leu Arg Asp Ile Thr Pro Asp Ala 
            900                 905                 910         


Lys Glu Asn Ile Leu Asn Met Asn Leu Pro Val Ser Ile Thr Val Lys 
        915                 920                 925             


Leu Thr Ala Asn Lys Gln Thr Phe Asn Thr Val Ile Thr His Pro Asn 
    930                 935                 940                 


Leu Lys Ile Lys Asn Ile Gly Asp Phe Tyr Ser Leu Ile Tyr Asp Ser 
945                 950                 955                 960 


Arg Leu Ser Ser Leu Val Arg Lys Tyr Gln Glu Leu Lys Asn Ile Asn 
                965                 970                 975     


Ser Asn Val Lys Ile Glu Phe Asp Tyr Gln Arg Ile Glu Lys Glu Phe 
            980                 985                 990         


Glu Asn Phe Asp His Thr Arg Ile  Asp Val Phe Lys Ile  Ile His Ser 
        995                 1000                 1005             


Leu Glu  Arg Ser Ile Ile Glu  Asp Asn Pro Asn Ile  Pro Asp Asp 
    1010                 1015                 1020             


Asp His  Asn Asn Phe Arg Ala  Leu Leu Gly Asp Gly  Lys Arg Phe 
    1025                 1030                 1035             


Ser Glu  Thr Glu Ile Asp Glu  Leu Ala Asp Ile Arg  Asn Ala Phe 
    1040                 1045                 1050             


Ser His  Asn His Tyr Asn Val  Ser Gly Leu Pro Asn  Thr Ala Glu 
    1055                 1060                 1065             


Leu Pro  Glu Ile Ala Lys Val  Ile Gly Lys Lys Ala  Glu Tyr Ile 
    1070                 1075                 1080             


Ser Gln  Lys Glu 
    1085         


<210>  2347
<211>  1145
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2347

Met Glu Thr Leu Thr Ile Pro Glu Val Ile Lys Cys Arg Thr Leu Ser 
1               5                   10                  15      


Asp Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Ile Ala Lys Glu Phe Asp Leu Pro Leu 
        35                  40                  45              


Leu Ala Glu Glu Gly His Leu Lys Asn Ser Phe Leu Cys Lys Lys Glu 
    50                  55                  60                  


His Asn Lys Val Asn Trp Asn His Val Tyr Ser Arg Thr Lys Arg Phe 
65                  70                  75                  80  


Leu Ala Val Leu Lys Val Phe Asp Ala Glu Thr Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Lys Thr Ile Asn Trp Glu Gly Lys Asp Phe Ala Ser Met Ser Asp 
            100                 105                 110         


Ile Leu Lys Ile Val Phe Gly Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Thr Ile Arg Lys Thr Ala Val 
    130                 135                 140                 


Ser Ala Glu Met Ala Leu Phe Leu Thr Thr Asn Phe Arg Arg Ala Ile 
145                 150                 155                 160 


Glu Tyr Thr Lys Glu Arg Phe Lys Gly Val Leu Asn Asp Glu Asp Tyr 
                165                 170                 175     


Gln Leu Val Ala Ser Lys Lys Val Leu Glu Ala Asn Ser Thr Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Arg Phe Ile Gly Ile Ile Thr Gly Leu Lys Gly Thr Gln Asn 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro His Asp Arg Phe Gln Ser Asp Asn Pro Arg Gln Ala Phe Ser 
                245                 250                 255     


Leu Asp Leu Ile Asn Glu Leu Asn Arg Cys Pro Lys Val Leu Tyr Asn 
            260                 265                 270         


Ala Ile Thr Glu Glu Gly Lys Gln Lys Leu Arg Ser Ile Pro Gly Glu 
        275                 280                 285             


Leu Glu Asn Lys Asn Leu His Asp Asn Asn Thr Lys Lys Glu Ala Lys 
    290                 295                 300                 


Ile Glu Ala Glu Ala Tyr Glu Leu Tyr Ile Glu Ser Leu Thr Arg Gln 
305                 310                 315                 320 


Ile Arg Tyr Ser Asn Arg Phe Pro Asp Phe Ala Leu Lys Phe Ile Asp 
                325                 330                 335     


Glu Thr Asp Ile Phe Ser Glu Phe Arg Phe Gln Ile Asp Leu Gly Lys 
            340                 345                 350         


Leu Leu Val Asp Glu Tyr Leu Lys Phe Phe Asn Gly Glu His Val Gln 
        355                 360                 365             


Arg Arg Ile Val Glu Asn Ala Lys Ala Phe Gly Lys Leu Ile Asp Phe 
    370                 375                 380                 


Asn Asp Glu Ala Lys Val Met Thr Arg Ile Gly Asn Gly His Phe Ser 
385                 390                 395                 400 


Lys Arg Phe Glu Gln Phe Ala Pro Phe Tyr Asn Thr Glu Asp Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Arg His His Val Thr Ala Lys Leu Gly Pro Asp Ser 
            420                 425                 430         


Lys Gly Glu Pro Glu Lys Lys Leu Leu Gln Pro Leu Pro Glu Ala Phe 
        435                 440                 445             


Leu Ser Leu His Glu Leu Pro Lys Val Ile Leu Leu Asp Tyr Leu Gln 
    450                 455                 460                 


Lys Gly Glu Pro Glu Lys Leu Ile Asn Asp Phe Ile Leu Ile Asn Asn 
465                 470                 475                 480 


Ser Lys Leu Met Asn Met Ser Phe Ile Glu Ala Val Lys Thr Gln Leu 
                485                 490                 495     


Pro Pro Glu Trp Asp Glu Phe Gln Arg Arg Thr Gly Ser Lys Asn Glu 
            500                 505                 510         


Met Pro Tyr Asn Glu Lys Thr Leu Ala Tyr Leu Leu Gln Arg Lys Gln 
        515                 520                 525             


Ile Leu Asn Lys Ile Leu Ala Glu Phe Gln Leu Asn Asp Lys Gln Ile 
    530                 535                 540                 


Pro Gly Arg Ile Leu Asp Tyr Trp Leu Asn Ile Ala Asp Val Glu Glu 
545                 550                 555                 560 


Glu Arg Ala Val Ser Asp Arg Ile Lys Ser Ile Lys Arg Asp Cys Met 
                565                 570                 575     


Ser Arg Leu Arg Ala Leu Gly Lys Phe Lys Ile Asp Arg Asn Arg Asn 
            580                 585                 590         


Lys Ile Pro Lys Ile Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile 
        595                 600                 605             


Val Asp Met Val Val Ser Glu Gly Lys Lys His Lys Ile Thr Ser Phe 
    610                 615                 620                 


Tyr Tyr Glu Lys Met Gln Asp Cys Leu Ser Leu Phe Ala Asp Pro Leu 
625                 630                 635                 640 


Lys Arg Gln Leu Phe Ile His Ile Ile Thr Asn Glu Leu Arg Leu Asn 
                645                 650                 655     


Asp Ser Gly Gly His Pro Phe Leu Phe Lys Leu Asn Met Arg Gln Ile 
            660                 665                 670         


Asn Cys Thr Ser Asp Phe Tyr Glu Ile Tyr Leu Gln Glu Lys Gly His 
        675                 680                 685             


Lys Met Val Pro Glu Lys Asn Leu Lys Thr Gly Lys Val Val Asn Thr 
    690                 695                 700                 


Asp His Ser Trp Met Ala Leu Thr Phe Tyr Lys Leu Glu Phe Asn Asp 
705                 710                 715                 720 


Lys Val Asp Lys Leu Met Thr Val Val Lys Leu Pro Leu Asn Lys Leu 
                725                 730                 735     


Asn Leu Pro Phe Thr Leu Arg Gln Leu Asn Ala Lys Thr Thr Tyr Thr 
            740                 745                 750         


Leu Glu Gln Trp Leu Lys Asn Leu Thr Leu Gly Lys Lys Pro Asp Asp 
        755                 760                 765             


Gly Lys His Pro Val Asn Leu Pro Thr Asn Leu Phe Asp Glu Lys Leu 
    770                 775                 780                 


Ser Asp Leu Leu Arg Gln Asp Leu Asp Asn Asn Lys Ile Ala Tyr Arg 
785                 790                 795                 800 


Pro Tyr Ala Asn Trp Asn Glu Leu Phe Lys Ile Trp Trp Ile Ser Arg 
                805                 810                 815     


Asn Asp Ser Leu Gln Arg Phe Tyr Asn Ala Glu Arg Glu Tyr His Ile 
            820                 825                 830         


Phe Asn Glu Lys Val Asn Phe Tyr Pro Asn Arg Lys Glu Asn Phe Ala 
        835                 840                 845             


Asp Tyr Tyr Gln His Ala Val Lys Val Ala Phe Gln Lys Lys Arg Asn 
    850                 855                 860                 


Glu Arg Ile Ile Glu Gln Arg Ile Asn Lys Tyr Leu Pro Asp Ile Leu 
865                 870                 875                 880 


Phe Glu Gln Val Glu Lys Thr Phe Lys His Thr Ile Ala Glu Thr Glu 
                885                 890                 895     


Lys Glu Ile Arg Ile Leu Gln Glu Glu Asp Arg Ile Met Leu Leu Met 
            900                 905                 910         


Leu Glu Gly Leu Met Glu Asp Gly Asn Lys Gln Gln Leu Lys Leu Ser 
        915                 920                 925             


Glu Ile Lys Thr Leu Gln Asn Ala Thr Ile Asn Ile Arg Gln Leu Val 
    930                 935                 940                 


Pro Gly Lys Leu Ser Phe Asp Asp Ser Gly Glu Ala Ile Lys Asp Ser 
945                 950                 955                 960 


Thr Asn Pro Glu Ile Val Arg Thr Val Ser Val Ser Ile Lys Arg Ile 
                965                 970                 975     


Glu Tyr Asn Leu Leu Pro Lys Tyr Val Ala Asp Gly Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Pro Asp Glu  Glu Ile Gln Met Glu  Arg Leu Lys 
        995                 1000                 1005             


Thr Glu  Phe Asp Thr Tyr Asn  Lys Val Arg Gln Val  Val Leu Asp 
    1010                 1015                 1020             


Leu Ser  Phe Lys Leu Glu Lys  Met Ile Ile Glu Lys  Gly His Lys 
    1025                 1030                 1035             


Asp Arg  Ile Asn Gln Leu Cys  Thr Gly Ala Thr Gly  Glu Leu Leu 
    1040                 1045                 1050             


Thr Gly  Asn Ile Cys His His  Thr Tyr Leu Thr Trp  Leu Lys Asp 
    1055                 1060                 1065             


Lys Glu  Met Ile Asp Asn Glu  Thr Phe Ile Phe Met  Asn Met Val 
    1070                 1075                 1080             


Gln His  Cys Phe Ser His Asn  Gln Tyr Pro Gln Lys  Lys Thr Met 
    1085                 1090                 1095             


Glu Arg  Ile Ile Asn His Trp  Glu Pro Asp Arg Phe  Ala Leu Thr 
    1100                 1105                 1110             


Ile Ala  Ala Thr Tyr Asn Gln  Lys Ile Ala Gly Ile  Leu Glu Asp 
    1115                 1120                 1125             


Ile Gly  Thr Phe Pro Phe Ile  Arg Ser Arg Lys Thr  Met Pro Asp 
    1130                 1135                 1140             


Val Val  
    1145 


<210>  2348
<211>  1125
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2348

Val Lys Met Glu Asp Asp Lys Lys Thr Thr Glu Ser Thr Asn Met Leu 
1               5                   10                  15      


Asp Asn Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Val Tyr Ile Thr Val Asn His Ile Asn Lys Val Leu Glu Leu Lys Asn 
        35                  40                  45              


Lys Lys Asp Gln Asp Ile Ile Ile Asp Asn Asp Gln Asp Ile Leu Ala 
    50                  55                  60                  


Ile Lys Thr His Trp Glu Lys Val Asp Gly Asp Leu Asn Lys Thr Glu 
65                  70                  75                  80  


Arg Leu Arg Glu Leu Met Thr Lys His Phe Pro Phe Leu Glu Thr Ala 
                85                  90                  95      


Ile Tyr Thr Lys Asn Lys Glu Asp Lys Glu Glu Val Lys Gln Glu Lys 
            100                 105                 110         


Gln Ala Lys Ala Gln Ser Phe Asp Ser Leu Lys His Cys Leu Phe Leu 
        115                 120                 125             


Phe Leu Glu Lys Leu Gln Glu Ala Arg Asn Tyr Tyr Ser His Tyr Lys 
    130                 135                 140                 


Tyr Ser Glu Ser Thr Lys Glu Pro Met Leu Glu Lys Glu Leu Leu Lys 
145                 150                 155                 160 


Lys Met Tyr Asn Ile Phe Asp Asp Asn Ile Gln Leu Val Ile Lys Asp 
                165                 170                 175     


Tyr Gln His Asn Lys Asp Ile Asn Pro Asp Glu Asp Phe Lys His Leu 
            180                 185                 190         


Asp Arg Lys Gly Gln Phe Lys Tyr Ser Phe Ala Asp Asn Glu Gly Asn 
        195                 200                 205             


Ile Thr Ala Ser Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys 
    210                 215                 220                 


Lys Asp Ala Ile Trp Met Gln Gln Lys Leu Thr Gly Phe Lys Asp Asn 
225                 230                 235                 240 


Arg Glu Ser Lys Arg Lys Met Thr His Glu Val Phe Cys Arg Arg Arg 
                245                 250                 255     


Met Leu Leu Pro Lys Leu Arg Leu Glu Ser Thr Gln Thr Gln Asp Trp 
            260                 265                 270         


Ile Leu Leu Asp Met Leu Asn Glu Leu Ile Arg Cys Pro Lys Ser Leu 
        275                 280                 285             


Tyr Glu Arg Leu Gln Gly Glu Tyr Arg Lys Lys Phe Asn Val Pro Phe 
    290                 295                 300                 


Asp Ser Ala Asp Glu Asp Tyr Asp Ala Glu Gln Glu Pro Phe Lys Asn 
305                 310                 315                 320 


Thr Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr 
                325                 330                 335     


Phe Asp Tyr Asn Glu Ile Phe Thr Asn Leu Arg Phe Gln Ile Asp Leu 
            340                 345                 350         


Gly Thr Tyr His Phe Ser Ile Tyr Lys Lys Leu Ile Gly Gly Asn Lys 
        355                 360                 365             


Glu Asp Arg His Leu Thr His Lys Leu Tyr Gly Phe Glu Arg Ile Gln 
    370                 375                 380                 


Glu Phe Asp Lys Gln Asn Arg Pro Asp Glu Trp Lys Ala Leu Val Lys 
385                 390                 395                 400 


Asp Leu Asp Thr Tyr Glu Thr Ser Asn Glu Arg Tyr Ile Ser Glu Thr 
                405                 410                 415     


Thr Pro His Tyr His Leu Glu Asn Gln Lys Ile Gly Ile Arg Phe Arg 
            420                 425                 430         


Asn Gly Asn Asn Asp Ile Trp Pro Ser Leu Glu Thr Asn Gly Glu Asn 
        435                 440                 445             


Asn Glu Lys Ser Lys Tyr Lys Leu Asp Lys Gln Tyr Gln Ala Glu Ala 
    450                 455                 460                 


Phe Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu 
465                 470                 475                 480 


Leu Lys Lys Glu Glu Pro Asn Asn Asp Lys Lys Asn Ala Ser Ile Val 
                485                 490                 495     


Glu Gly Phe Ile Lys Arg Glu Ile Arg Asp Ile Tyr Lys Leu Tyr Asp 
            500                 505                 510         


Ala Phe Ala Asn Gly Glu Ile Asn Asn Ile Asp Asp Leu Glu Lys Tyr 
        515                 520                 525             


Cys Glu Asp Lys Gly Ile Pro Lys Arg His Leu Pro Lys Gln Met Val 
    530                 535                 540                 


Ala Ile Leu Tyr Asp Glu His Lys Asp Met Val Glu Glu Ala Lys Arg 
545                 550                 555                 560 


Lys Gln Lys Glu Met Val Lys Asp Thr Lys Lys Leu Leu Ala Ala Leu 
                565                 570                 575     


Glu Lys Gln Thr Gln Gly Glu Ile Glu Asp Gly Gly Arg Asn Ile Arg 
            580                 585                 590         


Leu Leu Lys Ser Gly Glu Ile Ala Arg Trp Leu Val Asn Asp Met Met 
        595                 600                 605             


Arg Phe Gln Pro Val Gln Lys Asp Asn Glu Gly Asn Pro Leu Asn Asn 
    610                 615                 620                 


Ser Lys Ala Asn Ser Thr Glu Tyr Gln Met Leu Gln Arg Ser Leu Ala 
625                 630                 635                 640 


Leu Tyr Asn Lys Glu Glu Lys Pro Thr Arg Tyr Phe Arg Gln Val Asn 
                645                 650                 655     


Leu Ile Glu Ser Gly Asn Pro His Pro Phe Leu Lys Trp Thr Lys Trp 
            660                 665                 670         


Glu Glu Cys Asn Asn Ile Leu Ser Phe Tyr Arg Ser Tyr Leu Thr Lys 
        675                 680                 685             


Lys Ile Glu Phe Leu Asn Lys Leu Lys Pro Glu Asp Trp Lys Lys Asn 
    690                 695                 700                 


Gln Tyr Phe Leu Lys Leu Lys Glu Pro Lys Thr Asn Arg Glu Thr Leu 
705                 710                 715                 720 


Val Gln Gly Trp Lys Asn Gly Phe Asn Leu Pro Arg Gly Ile Phe Thr 
                725                 730                 735     


Glu Pro Ile Arg Glu Trp Phe Lys Arg His Gln Asn Asn Ser Lys Glu 
            740                 745                 750         


Tyr Lys Asn Val Glu Asp Leu Lys Arg Val Gly Leu Val Thr Lys Val 
        755                 760                 765             


Ile Pro Leu Phe Phe Lys Lys Glu Tyr Phe Lys Lys Asp Ala Gln Lys 
    770                 775                 780                 


Glu Ile Asn Asn Cys Val Gln Pro Phe Tyr Ser Phe Pro Tyr Asn Val 
785                 790                 795                 800 


Gly Asn Ile His Lys Pro Asp Glu Lys Asp Phe Leu Pro Ser Glu Glu 
                805                 810                 815     


Arg Lys Lys Leu Trp Gly Asp Lys Lys Tyr Lys Phe Lys Gly Tyr Lys 
            820                 825                 830         


Ala Lys Val Lys Ser Lys Lys Leu Thr Asp Lys Glu Lys Glu Glu Tyr 
        835                 840                 845             


Arg Ser Tyr Leu Glu Phe Gln Ser Trp Asn Lys Phe Glu Arg Glu Leu 
    850                 855                 860                 


Arg Leu Val Arg Asn Gln Asp Ile Val Thr Trp Leu Leu Cys Thr Glu 
865                 870                 875                 880 


Leu Ile Asp Lys Leu Lys Val Glu Gly Leu Asn Val Glu Glu Leu Lys 
                885                 890                 895     


Lys Leu Arg Leu Lys Asp Ile Asp Thr Asp Thr Ala Lys Lys Glu Lys 
            900                 905                 910         


Asn Asn Ile Leu Asn Arg Ile Met Pro Met Gln Leu Pro Val Thr Val 
        915                 920                 925             


Tyr Glu Ile Asp Asp Ser His Asn Ile Val Lys Asp Arg Pro Leu His 
    930                 935                 940                 


Thr Val Tyr Ile Glu Glu Thr Lys Thr Lys Leu Leu Lys Gln Gly Asn 
945                 950                 955                 960 


Phe Lys Ala Leu Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe 
                965                 970                 975     


Val Asp Thr Ser Ser Glu Ala Glu Leu Lys Ser Asn Pro Ile Ser Lys 
            980                 985                 990         


Ser Val Val Glu Tyr Glu Leu Gly  Glu Tyr Gln Asn Ala  Arg Ile Glu 
        995                 1000                 1005             


Ile Ile  Glu Asp Met Leu Ala  Leu Glu Gly Ala Leu  Ile Glu Lys 
    1010                 1015                 1020             


Asp Lys  Asn Leu Pro Thr Asp  Asn Phe Ser Asp Met  Leu Asn Gly 
    1025                 1030                 1035             


Trp Leu  Glu Gly Lys Asp Glu  Ser Asp Lys Ala Arg  Phe Gln Asn 
    1040                 1045                 1050             


Asp Val  Lys Leu Leu Val Ala  Val Arg Asn Ala Phe  Ser His Asn 
    1055                 1060                 1065             


Gln Tyr  Pro Met Arg Asn Arg  Ile Ala Phe Ala Asn  Ile Asn Pro 
    1070                 1075                 1080             


Phe Ser  Leu Ser Ser Ala Asp  Thr Ser Glu Glu Lys  Lys Leu Asp 
    1085                 1090                 1095             


Ile Ala  Asn Gln Leu Lys Asp  Lys Thr Lys Glu Thr  Ile Asp Lys 
    1100                 1105                 1110             


Ile Ile  Glu Ile Glu Lys Pro  Ile Glu Thr Lys Glu  
    1115                 1120                 1125 


<210>  2349
<211>  1121
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2349

Leu Gln Asn Thr Thr Asn Asn His Asn Phe Ala Pro Val Leu Thr Asn 
1               5                   10                  15      


Gly Ile Leu Thr Asn Lys Lys Ala Tyr Asp Met Asn Ile Pro Ala Leu 
            20                  25                  30          


Val Glu Asn Gln Lys Lys Tyr Phe Gly Thr Tyr Ser Val Met Ala Met 
        35                  40                  45              


Leu Asn Val Gln Thr Val Leu Asp His Ile Gln Lys Val Ala Asp Ile 
    50                  55                  60                  


Glu Gly Glu Gln Asn Glu Asn Asn Glu Asn Leu Trp Phe His Pro Val 
65                  70                  75                  80  


Met Ser His Leu Tyr Lys Ala Lys Lys Gly Tyr Asp Lys Gln Pro Glu 
                85                  90                  95      


Lys Thr Met Phe Ile Ile Glu Arg Leu Gln Ser Tyr Phe Pro Phe Leu 
            100                 105                 110         


Lys Ile Met Ala Glu Ser Gln Arg Glu Tyr Ser Asn Lys Lys Asn Lys 
        115                 120                 125             


Gln Asn Arg Val Glu Val Asn Ser Asn Asp Ile Phe Glu Val Leu Lys 
    130                 135                 140                 


Arg Ala Phe Gly Val Leu Lys Met Tyr Arg Asp Gln Thr Asn His Tyr 
145                 150                 155                 160 


Lys Thr Tyr Asp Glu Lys Leu Ile Asp Ser Cys Glu Phe Leu Thr Ser 
                165                 170                 175     


Thr Glu Leu Pro Leu Ser Lys Met Ile Asn Asp Tyr Tyr Thr Val Ala 
            180                 185                 190         


Leu Arg Asn Ile Lys Glu Arg Tyr Gly Tyr Lys Thr Glu Asp Leu Ala 
        195                 200                 205             


Phe Ile Gln Asp Asn Arg Tyr Lys Phe Thr Lys Asp Ala Tyr Gly Lys 
    210                 215                 220                 


Arg Lys Ser Gln Val Asn Thr Gly Phe Phe Leu Ser Leu Gln Asp Tyr 
225                 230                 235                 240 


Asn Gly Asp Thr Thr Lys Lys Leu His Leu Ser Gly Val Gly Ile Ala 
                245                 250                 255     


Leu Leu Ile Cys Leu Phe Leu Asp Lys Gln Tyr Ile Asn Leu Phe Leu 
            260                 265                 270         


Ser Arg Leu Pro Ile Phe Ser Ser Tyr Asn Ala Gln Ser Glu Glu Arg 
        275                 280                 285             


Arg Ile Ile Ile Arg Ser Phe Gly Ile Asn Ser Ile Lys Gln Pro Lys 
    290                 295                 300                 


Asp Arg Ile His Ser Glu Lys Ser Asn Lys Ser Val Ala Met Asp Met 
305                 310                 315                 320 


Leu Asn Glu Val Lys Arg Cys Pro Asp Glu Leu Phe Thr Thr Leu Ser 
                325                 330                 335     


Ala Glu Lys Gln Ser Arg Phe Arg Ile Ile Ser Asp Asp His Asn Glu 
            340                 345                 350         


Val Leu Met Lys Arg Ser Ser Asp Arg Phe Val Gln Leu Leu Leu Gln 
        355                 360                 365             


Tyr Ile Asp Tyr Gly Lys Leu Phe Lys Asn Ile Arg Phe His Val Asn 
    370                 375                 380                 


Met Gly Lys Leu Arg Tyr Leu Leu Lys Ala Asp Lys Lys Cys Ile Asp 
385                 390                 395                 400 


Gly Gln Ile Arg Val Arg Val Ile Glu Gln Pro Leu Asn Gly Phe Gly 
                405                 410                 415     


Lys Leu Asp Glu Val Glu Val Leu Arg Lys Gln Glu Asn Gly Thr Phe 
            420                 425                 430         


Gly Lys Ser Gly Ile Arg Ile Arg Asp Phe Glu Asn Met Lys Arg Asp 
        435                 440                 445             


Asp Asp Asn Pro Ala Asp Tyr Pro Tyr Ile Val Asp Thr Tyr Thr His 
    450                 455                 460                 


Tyr Met Leu Glu Asn Asn Lys Val Glu Met Tyr Ile Ser Lys Asp Asp 
465                 470                 475                 480 


Asn Pro Ala Pro Leu Leu Pro Glu Ile Glu Asp Asp Arg Tyr Ala Val 
                485                 490                 495     


Lys Thr Ile Pro Ser Cys Arg Met Ser Thr Leu Glu Phe Pro Ala Met 
            500                 505                 510         


Ala Phe His Met Phe Leu Leu Gly Ser Glu Arg Thr Glu Arg Arg Ile 
        515                 520                 525             


Lys Asp Val Tyr Asp Arg Tyr Lys Lys Leu Phe Arg Ala Met His Lys 
    530                 535                 540                 


Glu Glu Val Thr Ala Glu Asn Ile Ala Ser Phe Gly Ile Ala Glu Arg 
545                 550                 555                 560 


Asp Leu Pro Lys Lys Ile Leu Asp Ile Ile Asn Gly Asn Ala Gln Gly 
                565                 570                 575     


Lys Asp Val Asp Ala Tyr Ile Lys Ala Thr Ile Asp Asp Met Ile Ala 
            580                 585                 590         


Asp Thr Glu Gln Arg Ile Lys Lys Leu Lys Asp Asp Arg Lys Ala Val 
        595                 600                 605             


Arg Ser Ala Gly Asn Lys Met Gly Lys Arg Ser Phe Lys Arg Ile Ser 
    610                 615                 620                 


Thr Gly Lys Leu Ala Asp Phe Leu Ala Lys Asp Ile Val Met Phe Gln 
625                 630                 635                 640 


Pro Ser Ile Asn Asp Gly Glu Asn Lys Ile Thr Gly Leu Asn Tyr Arg 
                645                 650                 655     


Ile Met Gln Ser Ala Ile Ala Val Tyr Asp Ser Gly Asp Asn Tyr Glu 
            660                 665                 670         


Ser Lys Gln Gln Phe Arg Leu Met Phe Glu Lys Ala Gln Leu Ile Gly 
        675                 680                 685             


Lys Gly Ile Thr Glu Ala His Pro Phe Leu Tyr Lys Val Phe Ala Arg 
    690                 695                 700                 


Ser Ile Pro Ala Asn Ala Val Asp Phe Tyr Glu Arg Tyr Leu Ile Glu 
705                 710                 715                 720 


Arg Lys Tyr Tyr Leu Thr Ala Leu Phe Asn Glu Ile Lys Lys Gly Asn 
                725                 730                 735     


Lys Val Asp Ile Pro Phe Ile Arg Arg Asn Gln Ser Lys Trp Lys Thr 
            740                 745                 750         


Pro Val Met Lys Thr Leu Gly Arg Ile Tyr Asn Glu Glu Leu Pro Val 
        755                 760                 765             


Glu Leu Pro Arg Gln Met Phe Asp Asp Glu Ile Lys Ser His Leu Lys 
    770                 775                 780                 


Ser Leu Ser Gln Met Ser Gly Ile Asp Phe Asp Asn Ala Asn Val Thr 
785                 790                 795                 800 


Tyr Leu Ile Ala Glu Tyr Met Lys Arg Val Leu Gly Asp Asp Phe Gln 
                805                 810                 815     


Asn Phe Tyr Gln Trp Asn Arg Asn Tyr Arg Tyr Met Asp Met Leu Lys 
            820                 825                 830         


Gly Glu Tyr Asp Ser Lys Gly Thr Leu Leu Cys Asn Phe Thr Ser Val 
        835                 840                 845             


Glu Glu Arg Glu Ala Leu Trp Lys Glu Arg Glu Asp Arg Ser Gly Ser 
    850                 855                 860                 


Tyr Arg Lys Leu Ala Ala Lys Lys Ile Lys Ser Asn Arg Leu Met Arg 
865                 870                 875                 880 


Asn Ala Ser Thr Asp Glu Val Asn Ser Ile Leu Asp Lys Gln Leu Ser 
                885                 890                 895     


Asn Ser Arg Asn Glu Tyr Gln Lys Asn Glu Lys Ile Ile Arg Arg Tyr 
            900                 905                 910         


Lys Val Gln Asp Ala Leu Leu Phe Leu Leu Ala Lys Lys Ser Leu Thr 
        915                 920                 925             


Glu Met Ala Asp Phe Asp Gly Asn Lys Phe Lys Leu Lys Glu Ile Met 
    930                 935                 940                 


Ser Asp Thr Glu Lys Gly Ile Leu Ser Glu Ile Met Pro Met Thr Phe 
945                 950                 955                 960 


Thr Phe Glu Lys Gly Gly Lys Arg Tyr Thr Ile Thr Ser Glu Gly Met 
                965                 970                 975     


Lys Leu Lys Asn Tyr Gly Asp Phe Phe Val Leu Ala Asn Asp Lys Arg 
            980                 985                 990         


Leu Tyr Arg Leu Leu Lys Ile Val  Gly Ser Asn Thr Val  Ser Lys Glu 
        995                 1000                 1005             


Asp Ile  Met Glu Glu Phe Lys  Lys Tyr Asp Gln Ser  Arg Pro Glu 
    1010                 1015                 1020             


Val Val  Gly Leu Val Phe Asp  Leu Glu Lys Trp Ala  Phe Asp Thr 
    1025                 1030                 1035             


Tyr Pro  Glu Leu Leu Ala Arg  Val Asp Arg Lys Glu  Lys Val Asp 
    1040                 1045                 1050             


Phe Lys  Ala Val Leu Asp Val  Leu Ile Lys Asn Asn  Asn Ile Asp 
    1055                 1060                 1065             


Ser Lys  Gln Leu His Val Leu  Lys Thr Ile Arg Asn  Ala Phe Asp 
    1070                 1075                 1080             


His Asn  Asp Tyr Pro Asp Lys  Asp Lys Ile Glu Asn  Gly Ile Ile 
    1085                 1090                 1095             


Glu Ile  Thr Thr Leu Pro Lys  Ile Ala Ile Gly Ile  Lys Asn Leu 
    1100                 1105                 1110             


Phe Gly  Glu Tyr Ala Met Met  Lys 
    1115                 1120     


<210>  2350
<211>  1149
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2350

Met Lys Lys Ile Leu Pro Cys Ser Tyr Lys Ser Asn Phe Gln Asn Leu 
1               5                   10                  15      


Ile Tyr Leu Leu Pro Met Asp Val Thr Ile Lys Phe Lys Lys Ile Phe 
            20                  25                  30          


Asp Thr Lys Gly Ile Ile Ala Pro Ile Ser Glu Lys Ala His Arg Asn 
        35                  40                  45              


Phe Lys Met Lys Phe Lys Val Asp Glu Gln Asn Arg Asn Lys Ala Ile 
    50                  55                  60                  


His Tyr Tyr Gly Ile Gly His Val Phe Lys Asn Leu Asn Thr Lys Ser 
65                  70                  75                  80  


Tyr Phe Asn Phe Gln Val Asp Asn Ser Asn Glu Asn Val Tyr Pro Thr 
                85                  90                  95      


Arg Phe Leu Asn Leu Gln Lys Glu Asn Phe Asp Phe Ala Glu Asn Phe 
            100                 105                 110         


Glu Arg Leu Leu Ala Ser Ile Arg Asp Ile Asn Ser His Tyr Ile His 
        115                 120                 125             


Thr Phe Asp Arg Leu Ser Ile Ala Glu Leu Asp Asn Leu Ser Pro Lys 
    130                 135                 140                 


Ile Ile Pro Phe Leu Leu Glu Ala Phe Glu Leu Ala Cys Ile Asp Thr 
145                 150                 155                 160 


Met Leu Lys Glu Lys Lys Leu Glu Pro Asp Tyr Tyr Tyr Leu Asp Gln 
                165                 170                 175     


Val Lys Gly Glu Lys Glu Leu Val Lys Phe Leu Gly Asn Lys Phe Tyr 
            180                 185                 190         


Pro Asn Asp Glu Tyr Gln Lys Thr Glu Arg Glu Ile Phe Phe Lys Leu 
        195                 200                 205             


Ser Leu Asn Lys Ala Ile Gln Asp Ile Leu Phe Ile Gln Val Asp Glu 
    210                 215                 220                 


Lys Ile Thr Trp Lys Leu Phe Asn Asp Tyr Glu Ile Phe Asp Ile Lys 
225                 230                 235                 240 


Glu Gly Lys Tyr Leu Ser Phe Tyr Ala Ser Leu Phe Leu Ile Ser Met 
                245                 250                 255     


Phe Leu Tyr Lys Asn Glu Ala Ile Gln Leu Ile Ser Lys Ile Lys Gly 
            260                 265                 270         


Phe Lys Lys Thr Asp Gly Glu Val Ser Gln Ser Lys Arg Asn Ile Phe 
        275                 280                 285             


Ser Phe Phe Ser Lys Lys Phe Ser Ser Gln Asp Val Asp Ser Glu Asn 
    290                 295                 300                 


Leu Asn Leu Ile Lys Phe Arg Asp Ile Ile Gln Tyr Leu Asn His Tyr 
305                 310                 315                 320 


Pro Val Cys Trp Asn Lys His Leu Glu Leu Glu Ser Ser Phe Pro Glu 
                325                 330                 335     


Met Thr Asn Lys Leu Ile Asn Ser Ile Ile Glu Ile Glu Ile Ser Arg 
            340                 345                 350         


Ile Phe Pro Asp Gly Val Lys Ile Asp Lys Glu Arg Phe Ile Leu Phe 
        355                 360                 365             


Ser Lys Gln Asn Leu Phe Ser Lys Tyr Tyr Pro Lys Lys Lys Leu Asn 
    370                 375                 380                 


Leu Glu Tyr Ala Asn Ala Glu Tyr Asp Ile Asp Glu Ile Glu Leu Phe 
385                 390                 395                 400 


Gln Asp Lys Ile Ile Asn Gln Ser Pro Lys Leu Lys Asn Ile Tyr Ser 
                405                 410                 415     


Asn Leu Ser Ala Leu Glu Ile Lys Leu Arg Lys Gln Asn Ile Ser Glu 
            420                 425                 430         


Lys Glu Lys Lys Glu Ile Leu Ser Thr Lys Arg Lys Leu Glu Ser Glu 
        435                 440                 445             


Leu Glu Ile Glu Ile Lys Thr Pro Asn Pro Asp Val Thr Lys Leu Asn 
    450                 455                 460                 


Gln Lys Leu Asp Asn Asn Leu Phe Ile Ser Ser Tyr Gly Arg Asn Lys 
465                 470                 475                 480 


Asp Arg Phe Phe Asp Phe Ser Leu Arg Phe Leu Ala Glu Ile Asn Tyr 
                485                 490                 495     


Phe Gly Glu Asp Ala Lys Phe Gln Cys Tyr Gln Phe Tyr Thr Thr Asp 
            500                 505                 510         


Glu Gln Val Lys Phe Leu Ile Asp Ile Lys Asp Lys Ile Glu Lys Lys 
        515                 520                 525             


Glu Phe Glu Lys Leu Lys Tyr His Gln Gly Lys Leu Thr His Phe Ile 
    530                 535                 540                 


Thr Tyr Lys Glu His Leu Asn Lys Tyr Asp Asp Trp Tyr Ile Pro Phe 
545                 550                 555                 560 


Val Lys Glu Asn Asn Ala Phe Gln Ile Glu Ile Ile Leu Gly Asn Ser 
                565                 570                 575     


Glu Lys Lys Ile Ile Ser Ile Gln Arg Ser Leu Leu Ile Tyr Phe Leu 
            580                 585                 590         


His Asp Ala Leu Tyr Asn Pro Thr Pro Asn Gly Leu Asn Ser Ile Thr 
        595                 600                 605             


Asn Tyr Tyr Phe His Phe Leu Gln Asp Phe Glu Thr Gly Leu Ala Thr 
    610                 615                 620                 


Leu Lys Asn Ser Glu Asn Gln Ser Val Leu Asn Asn Asn Lys Ile Lys 
625                 630                 635                 640 


Lys Ile Phe Pro Arg Lys Leu Phe Ala Lys Ile Asn Asn Asn Gln Asn 
                645                 650                 655     


Ser Val Asn His Asn Pro Tyr Leu Ala Phe Leu Thr Glu Thr Lys Asn 
            660                 665                 670         


Lys Glu Leu Arg Tyr Glu Asn Leu Leu Thr Lys Ala Arg Lys Phe Asn 
        675                 680                 685             


Arg Glu Asp Asp Phe Leu Lys Lys Asn Lys Gly Lys Gln Phe Lys Leu 
    690                 695                 700                 


Asn Phe Ile Lys Lys Ala Trp Gln Leu Met Tyr Phe Lys Pro Ile Tyr 
705                 710                 715                 720 


Leu Glu Lys Val Thr Ile Asn Gly His His Lys Gln Tyr Asn Ile Thr 
                725                 730                 735     


Lys Ala Glu Phe Glu Asn Tyr Cys Arg Trp Met Phe Gly Phe Glu Thr 
            740                 745                 750         


Thr Pro Ser Tyr Lys Thr Ala Leu Glu Asn Leu Phe His Ser Lys Gly 
        755                 760                 765             


Phe Phe Asn Asn Ser Asp Phe Lys Glu Leu Phe Glu Lys Gly Thr Ser 
    770                 775                 780                 


Leu Glu Asp Trp Tyr Lys Lys Thr Lys Thr Lys Phe Glu Lys Trp Ile 
785                 790                 795                 800 


Leu Asn Gln Thr Gln Asn Ser Lys Asn Lys Ile Thr Asp Phe Ala Asn 
                805                 810                 815     


Tyr Pro Asn Leu Asn Lys Asn Gln Ile Leu Tyr Ile Asn Leu Ser His 
            820                 825                 830         


Tyr Leu Ser Tyr Leu Glu Ser Lys Gly Glu Ile Ile Arg Gln Glu Asn 
        835                 840                 845             


Lys Gln Ile His Tyr Pro Ser Leu Ser Asn Asn Ile Tyr Leu Ile Asp 
    850                 855                 860                 


Ser Tyr Tyr Tyr Ser Thr Ile Leu Ile Asp Lys Glu Gln Lys Lys His 
865                 870                 875                 880 


Gly Lys Leu Phe Asn Glu Leu Arg Lys Ala Arg Leu Glu Asp Ser Ile 
                885                 890                 895     


Leu Tyr Glu Ile Ala Met Val Tyr Phe Ser Lys Asn Gln Asn Ile Val 
            900                 905                 910         


Pro Asn Ile Lys Asn Asn Val Tyr Asn Ile Leu Thr Glu Thr Ile Glu 
        915                 920                 925             


Phe Glu Ile Lys Asn Ala Lys Gln Ile Ser Leu Tyr Lys Phe Glu Ile 
    930                 935                 940                 


Pro Phe Ser Lys Ile Asp Ser Tyr Leu Glu Leu Ile Ala His Lys Asn 
945                 950                 955                 960 


Asp Gln Glu Leu Glu Phe Lys Gly Ser Ser Phe Met Ser Arg Val Phe 
                965                 970                 975     


Glu Tyr Leu Gln Lys Leu Asn Leu His Ser Asn Ser Leu Lys Val Glu 
            980                 985                 990         


Asn Glu Leu Lys Glu Ile Tyr Lys  Cys Gly Ser Leu Thr  Tyr Asp Ser 
        995                 1000                 1005             


Leu Asn  Lys Phe Tyr Ala Tyr  Ile Met Asn Gln Ser  Leu Leu Phe 
    1010                 1015                 1020             


Thr Asp  Leu Asn Met Ala Ile  Glu Leu Tyr Phe Ile  Asn Arg Asp 
    1025                 1030                 1035             


Lys Leu  Lys Ile His Asn Ser  Asn Arg Ile Glu Tyr  Lys Asp Ile 
    1040                 1045                 1050             


Leu Pro  Leu Thr Lys Asp Asn  Tyr Tyr Thr Ser Ile  Ile Arg Asn 
    1055                 1060                 1065             


Arg Ala  Phe His Phe Gly Ile  Pro Glu Lys Asn Tyr  Arg Glu Leu 
    1070                 1075                 1080             


Ile Asn  Glu Ile Gln Lys Ile  Tyr Phe Glu Lys Glu  Ile Lys Asn 
    1085                 1090                 1095             


Lys Gly  Leu Ile Asn Thr Ser  Gln Leu Thr Lys Ser  His Ser Leu 
    1100                 1105                 1110             


Leu Ile  Asp Lys Ile Ile Thr  Ile Met Phe Asn Asn  Leu Tyr Asp 
    1115                 1120                 1125             


Lys Asn  Ile Asp Thr Arg Glu  Arg Ile Ile Asn Ala  Arg Asn Lys 
    1130                 1135                 1140             


Tyr Leu  Glu Gly Gln Asn 
    1145                 


<210>  2351
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2351

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Lys Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Leu Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2352
<211>  1145
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2352

Met Glu Thr Leu Thr Ile Pro Glu Val Ile Lys Cys Arg Thr Leu Ser 
1               5                   10                  15      


Asp Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Ile Ala Lys Glu Phe Asp Leu Pro Leu 
        35                  40                  45              


Leu Ala Glu Glu Gly His Leu Lys Asn Ser Phe Leu Cys Lys Lys Glu 
    50                  55                  60                  


His Asn Lys Val Asn Trp Asn His Val Tyr Ser Arg Thr Lys Arg Phe 
65                  70                  75                  80  


Leu Ala Val Leu Lys Val Phe Asp Ala Glu Thr Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Lys Thr Ile Asn Trp Glu Gly Lys Asp Phe Ala Ser Met Ser Asp 
            100                 105                 110         


Ile Leu Lys Ile Val Phe Gly Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Thr Ile Arg Lys Thr Ala Val 
    130                 135                 140                 


Ser Ala Glu Met Ala Leu Phe Leu Thr Thr Asn Phe Arg Arg Ala Ile 
145                 150                 155                 160 


Glu Tyr Thr Lys Glu Arg Phe Lys Gly Val Leu Asn Asp Glu Asp Tyr 
                165                 170                 175     


Gln Leu Val Ala Ser Lys Lys Val Leu Glu Ala Asn Ser Thr Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Arg Phe Ile Gly Ile Ile Thr Gly Leu Lys Gly Thr Gln Asn 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro His Asp Arg Phe Gln Ser Asp Asn Pro Arg Gln Ala Phe Ser 
                245                 250                 255     


Leu Asp Leu Ile Asn Glu Leu Asn Arg Cys Pro Lys Val Leu Tyr Asn 
            260                 265                 270         


Ala Ile Thr Glu Glu Gly Lys Gln Lys Leu Arg Ser Ile Pro Gly Glu 
        275                 280                 285             


Leu Glu Asn Lys Asn Leu His Asp Asn Asn Thr Lys Lys Glu Ala Lys 
    290                 295                 300                 


Ile Glu Ala Glu Ala Tyr Glu Leu Tyr Ile Glu Ser Leu Thr Arg Gln 
305                 310                 315                 320 


Ile Arg Tyr Ser Asn Arg Phe Pro Asp Phe Ala Leu Lys Phe Ile Asp 
                325                 330                 335     


Glu Thr Asp Ile Phe Ser Glu Phe Arg Phe Gln Ile Asp Leu Gly Lys 
            340                 345                 350         


Leu Leu Val Asp Glu Tyr Leu Lys Phe Phe Asn Gly Glu His Val Gln 
        355                 360                 365             


Arg Arg Ile Val Glu Asn Ala Lys Ala Phe Gly Lys Leu Ile Asp Phe 
    370                 375                 380                 


Asn Asp Glu Ala Lys Val Met Thr Arg Ile Gly Asn Gly His Phe Ser 
385                 390                 395                 400 


Lys Arg Phe Glu Gln Phe Ala Pro Phe Tyr Asn Thr Glu Asp Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Arg His His Val Thr Ala Lys Leu Gly Pro Asp Ser 
            420                 425                 430         


Lys Gly Glu Pro Glu Lys Lys Leu Leu Gln Pro Leu Pro Glu Ala Phe 
        435                 440                 445             


Leu Ser Leu His Glu Leu Pro Lys Val Ile Leu Leu Asp Tyr Leu Gln 
    450                 455                 460                 


Lys Gly Glu Pro Glu Lys Leu Ile Asn Asp Phe Ile Leu Ile Asn Asn 
465                 470                 475                 480 


Ser Lys Leu Met Asn Met Ser Phe Ile Glu Ala Val Lys Thr Gln Leu 
                485                 490                 495     


Pro Pro Glu Trp Asp Glu Phe Gln Arg Arg Thr Gly Ser Lys Asn Glu 
            500                 505                 510         


Met Pro Tyr Asn Glu Lys Thr Leu Ala Tyr Leu Leu Gln Arg Lys Gln 
        515                 520                 525             


Ile Leu Asn Lys Ile Leu Ala Glu Phe Gln Leu Asn Asp Lys Gln Ile 
    530                 535                 540                 


Pro Gly Arg Ile Leu Asp Tyr Trp Leu Asn Ile Ala Asp Val Glu Glu 
545                 550                 555                 560 


Glu Arg Ala Val Ser Asp Arg Ile Lys Ser Ile Lys Arg Asp Cys Met 
                565                 570                 575     


Ser Arg Leu Arg Ala Leu Gly Lys Phe Lys Ile Asp Arg Asn Arg Asn 
            580                 585                 590         


Lys Ile Pro Lys Ile Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile 
        595                 600                 605             


Val Asp Met Val Val Ser Glu Gly Lys Lys His Lys Ile Thr Ser Phe 
    610                 615                 620                 


Tyr Tyr Glu Lys Met Gln Asp Cys Leu Ser Leu Phe Ala Asp Pro Leu 
625                 630                 635                 640 


Lys Arg Gln Leu Phe Ile His Ile Ile Thr Asn Glu Leu Arg Leu Asn 
                645                 650                 655     


Asp Ser Gly Gly His Pro Phe Leu Phe Lys Leu Asn Met Arg Gln Ile 
            660                 665                 670         


Asn Cys Thr Ser Asp Phe Tyr Glu Ile Tyr Leu Gln Glu Lys Gly His 
        675                 680                 685             


Lys Met Val Pro Glu Lys Asn Leu Lys Thr Gly Lys Val Val Asn Thr 
    690                 695                 700                 


Asp His Ser Trp Met Ala Leu Thr Phe Tyr Lys Leu Glu Phe Asn Asp 
705                 710                 715                 720 


Lys Val Asp Lys Leu Met Thr Val Val Lys Leu Pro Leu Asn Lys Leu 
                725                 730                 735     


Asn Leu Pro Phe Thr Leu Arg Gln Leu Asn Ala Lys Thr Thr Tyr Thr 
            740                 745                 750         


Leu Glu Gln Trp Leu Lys Asn Leu Thr Leu Gly Lys Lys Pro Asp Asp 
        755                 760                 765             


Gly Lys His Pro Val Asn Leu Pro Thr Asn Leu Phe Asp Glu Lys Leu 
    770                 775                 780                 


Ser Asp Leu Leu Arg Gln Asp Leu Asp Asn Asn Lys Ile Ala Tyr Arg 
785                 790                 795                 800 


Pro Tyr Ala Asn Trp Asn Glu Leu Phe Lys Ile Trp Trp Ile Ser Arg 
                805                 810                 815     


Asn Asp Ser Leu Gln Arg Phe Tyr Asn Ala Glu Arg Glu Tyr His Ile 
            820                 825                 830         


Phe Asn Glu Lys Val Asn Phe Tyr Pro Asn Arg Lys Glu Asn Phe Ala 
        835                 840                 845             


Asp Tyr Tyr Gln His Ala Val Lys Val Ala Phe Gln Lys Lys Arg Asn 
    850                 855                 860                 


Glu Arg Ile Ile Glu Gln Arg Ile Asn Lys Tyr Leu Pro Asp Ile Leu 
865                 870                 875                 880 


Phe Glu Gln Val Glu Lys Thr Phe Lys His Thr Ile Ala Glu Thr Glu 
                885                 890                 895     


Lys Glu Ile Arg Ile Leu Gln Glu Glu Asp Arg Ile Met Leu Leu Met 
            900                 905                 910         


Leu Glu Gly Leu Met Glu Asp Gly Asn Lys Gln Gln Leu Lys Leu Ser 
        915                 920                 925             


Glu Ile Lys Thr Leu Gln Asn Ala Thr Ile Asn Ile Arg Gln Leu Val 
    930                 935                 940                 


Pro Gly Lys Leu Ser Phe Asp Asp Ser Gly Glu Ala Ile Lys Asp Ser 
945                 950                 955                 960 


Thr Asn Pro Glu Ile Val Arg Thr Val Ser Val Ser Ile Lys Arg Ile 
                965                 970                 975     


Glu Tyr Asn Leu Leu Pro Lys Tyr Val Ala Asp Gly Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Pro Asp Glu  Glu Ile Gln Met Glu  Arg Leu Lys 
        995                 1000                 1005             


Thr Glu  Phe Asp Thr Tyr Asn  Lys Val Arg Gln Val  Val Leu Asp 
    1010                 1015                 1020             


Leu Ser  Phe Lys Leu Glu Lys  Met Ile Ile Glu Lys  Gly His Lys 
    1025                 1030                 1035             


Asp Arg  Ile Asn Gln Leu Cys  Thr Gly Ala Thr Gly  Glu Leu Leu 
    1040                 1045                 1050             


Thr Gly  Asn Ile Cys His His  Thr Tyr Leu Thr Trp  Leu Lys Asp 
    1055                 1060                 1065             


Lys Glu  Met Ile Asp Asn Glu  Thr Phe Ile Phe Met  Asn Met Val 
    1070                 1075                 1080             


Gln His  Cys Phe Ser His Asn  Gln Tyr Pro Gln Lys  Lys Thr Met 
    1085                 1090                 1095             


Glu Arg  Ile Ile Asn His Trp  Glu Pro Asp Arg Phe  Ala Leu Thr 
    1100                 1105                 1110             


Ile Ala  Ala Thr Tyr Asn Gln  Lys Ile Ala Gly Ile  Leu Glu Asp 
    1115                 1120                 1125             


Ile Gly  Thr Phe Pro Phe Ile  Arg Ser Arg Lys Thr  Met Pro Asp 
    1130                 1135                 1140             


Val Val  
    1145 


<210>  2353
<211>  1146
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2353

Met Glu Ser Ile Ile Gly Leu Gly Leu Ser Phe Asn Pro Tyr Lys Thr 
1               5                   10                  15      


Ala Asp Lys His Tyr Phe Gly Ser Phe Leu Asn Leu Ala Asp Asn Asn 
            20                  25                  30          


Leu Lys Ala Val Phe Ala Glu Phe Lys Glu Arg Ile Ser Asp Lys Ser 
        35                  40                  45              


Lys Asp Glu Asp Ile Ser Asn Leu Ile Glu Lys His Phe Ile Asp Asn 
    50                  55                  60                  


Met Ser Ile Val Asp Tyr Glu Lys Asn Ile Ser Ile Leu Asn Gly Tyr 
65                  70                  75                  80  


Leu Pro Ile Ile Asp Phe Leu Asp Asp Glu Leu Glu Asn Asn Leu Asn 
                85                  90                  95      


Thr Arg Val Lys Asn Phe Lys Lys Ser Phe Ile Ile Leu Ala Glu Ala 
            100                 105                 110         


Leu Glu Thr Leu Arg Asn Tyr Tyr Thr His Phe Tyr His Asp Pro Ile 
        115                 120                 125             


Thr Phe Gly Asp Asn Lys Glu Pro Leu Leu Glu Leu Leu Asp Glu Val 
    130                 135                 140                 


Leu Leu Lys Thr Ile Leu Asp Val Lys Lys Lys Tyr Leu Lys Thr Asp 
145                 150                 155                 160 


Lys Thr Lys Glu Ile Leu Lys Asp Ser Leu Arg Glu Glu Met Asp Leu 
                165                 170                 175     


Leu Val Ile Arg Lys Thr Asp Glu Leu Arg Glu Lys Lys Lys Thr Asn 
            180                 185                 190         


Pro Lys Phe Lys Phe Ser Thr Asp Pro Thr Gln Ile Arg Asn Ser Ile 
        195                 200                 205             


Phe Asn Asp Ala Phe Gln Gly Leu Leu Tyr Glu Asp Lys Glu Asn Asn 
    210                 215                 220                 


Gly Lys Thr Gln Val Ser Tyr Arg Ala Lys Thr Lys Leu Asn Pro Lys 
225                 230                 235                 240 


Asp Ile His Lys Gln Glu Glu Arg Asp Phe Glu Ile Pro Leu Ser Thr 
                245                 250                 255     


Ser Gly Ile Val Phe Leu Met Ser Leu Phe Leu Ser Lys Lys Glu Ile 
            260                 265                 270         


Glu Asp Phe Lys Ser Asn Ile Lys Gly Phe Lys Gly Lys Val Val Lys 
        275                 280                 285             


Asp Glu Asn His Asn Ser Leu Lys Tyr Met Ala Thr His Arg Val Tyr 
    290                 295                 300                 


Ser Ile Leu Ala Phe Lys Gly Leu Lys Tyr Arg Ile Lys Thr Asp Thr 
305                 310                 315                 320 


Phe Ser Lys Val Thr Leu Met Met Gln Met Ile Asp Glu Leu Ser Lys 
                325                 330                 335     


Val Pro Asp Cys Val Tyr Gln Asn Leu Ser Glu Thr Lys Gln Lys Asp 
            340                 345                 350         


Phe Ile Glu Asp Trp Asn Glu Tyr Leu Lys Asp Asn Glu Glu Asn Thr 
        355                 360                 365             


Glu Asn Leu Glu Asn Ser Arg Val Val His Pro Leu Ile Arg Lys Arg 
    370                 375                 380                 


Tyr Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe 
385                 390                 395                 400 


Ala Asn Phe Lys Thr Leu Lys Phe Gln Val Phe Met Gly Tyr Tyr Ile 
                405                 410                 415     


His Asp Gln Arg Thr Lys Thr Ile Gly Thr Thr Asn Ile Thr Thr Glu 
            420                 425                 430         


Arg Thr Val Lys Glu Lys Ile Asn Val Phe Gly Lys Leu Ser Lys Met 
        435                 440                 445             


Asp Asn Leu Lys Lys His Phe Phe Ser Gln Leu Ser Asp Glu Glu Asn 
    450                 455                 460                 


Thr Asp Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Phe Leu Thr Gln 
465                 470                 475                 480 


Ala Asp Asn Ser Pro Ala Asn Asn Ile Pro Ile Tyr Leu Glu Leu Lys 
                485                 490                 495     


Asn Gln Gln Ile Ile Lys Glu Lys Asp Asp Ile Lys Ala Glu Val Asn 
            500                 505                 510         


Asn Ser Gln Asn Arg Asn Pro Asn Lys Pro Ser Lys Arg Asp Leu Leu 
        515                 520                 525             


Asn Lys Ile Ser Asn Thr Asn Glu Asp Phe Tyr Gln Gly Asp Pro Thr 
    530                 535                 540                 


Ala Ile Leu Ser Leu Asn Glu Ile Pro Ala Leu Leu His Leu Phe Leu 
545                 550                 555                 560 


Val Gln Pro Asp Asn Lys Thr Gly Gln Gln Ile Glu Asn Ile Ile Arg 
                565                 570                 575     


Ile Lys Ile Glu Lys Gln Phe Asn Ser Ile Lys Asn Pro Ser Lys Asp 
            580                 585                 590         


Asp Lys Gly Val Pro Lys Ser Leu Phe Ala Asp Thr Asn Val Arg Val 
        595                 600                 605             


Asn Ala Ile Lys Leu Lys Lys Asp Leu Gly Glu Glu Leu Asp Met Leu 
    610                 615                 620                 


Asn Lys Lys Gln Ile Val Phe Lys Glu Asn Gln Lys Ala Ser Ser Asn 
625                 630                 635                 640 


Tyr Asp Glu Leu Leu Lys Lys His Gln Phe Thr Pro Lys Asn Lys Arg 
                645                 650                 655     


Pro Ala Leu Arg Lys Tyr Val Phe Tyr Asn Ser Glu Lys Gly Glu Glu 
            660                 665                 670         


Ala Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Lys Gly Phe 
        675                 680                 685             


Lys Thr Lys Trp Lys Gly Tyr Gln His Ser Glu Leu Gln Arg Lys Leu 
    690                 695                 700                 


Ala Phe Tyr Asp Arg His Thr Lys Gln Asp Ile Lys Glu Leu Leu Ser 
705                 710                 715                 720 


Gly Cys Glu Phe Asp His Phe Leu Leu Asp Ile Asn Ala Cys Phe Lys 
                725                 730                 735     


Glu Asp Asp Phe Glu Asp Phe Phe Ser Lys Tyr Leu Lys Asn Arg Ile 
            740                 745                 750         


Glu Thr Leu Asn Ile Ile Leu Lys Gln Leu His Asp Phe Lys Asn Glu 
        755                 760                 765             


Pro Thr Pro Leu Lys Gly Val Phe Lys Asn Cys Leu Lys Phe Leu Lys 
    770                 775                 780                 


Gln Lys Asn Tyr Val Thr Glu Asn Pro Glu Ile Ile Lys Lys Arg Ile 
785                 790                 795                 800 


Leu Ala Lys Pro Ala Phe Leu Pro Arg Gly Ile Phe Asp Glu Arg Pro 
                805                 810                 815     


Thr Met Lys Lys Gly Lys Asn Pro Leu Ile Asp Arg Asp Glu Phe Ala 
            820                 825                 830         


Lys Trp Phe Val Glu Tyr Leu Glu Asn Lys Asp Tyr Gln Lys Phe Tyr 
        835                 840                 845             


Asn Ser Glu Glu Tyr Arg Ile Arg Asp Ala Asp Phe Lys Lys Asn Ala 
    850                 855                 860                 


Val Ile Lys Lys Gln Lys Leu Lys Asp Phe Tyr Thr Leu Gln Met Val 
865                 870                 875                 880 


Asn Tyr Leu Leu Lys Glu Val Phe Gly Lys Asp Glu Met Asn Leu Gln 
                885                 890                 895     


Leu Ser Glu Leu Phe Gln Thr Arg Gln Glu Arg Leu Lys Leu Gln Gly 
            900                 905                 910         


Ile Ala Lys Lys Gln Met Asn Lys Glu Thr Gly Asp Ser Ser Glu Asn 
        915                 920                 925             


Thr Arg Asn Gln Thr Tyr Ile Trp Asn Lys Asp Val Pro Val Ser Phe 
    930                 935                 940                 


Phe Asn Gly Lys Val Thr Ile Asp Lys Val Lys Leu Lys Asn Ile Gly 
945                 950                 955                 960 


Lys Tyr Lys Arg Tyr Glu Arg Asp Glu Arg Val Lys Thr Phe Ile Gly 
                965                 970                 975     


Tyr Glu Val Asp Glu Lys Trp Met Met Tyr Leu Pro His Asn Trp Lys 
            980                 985                 990         


Asp Arg Tyr Ser Val Lys Pro Ile  Asn Val Ile Asp Leu  Gln Ile Gln 
        995                 1000                 1005             


Glu Tyr  Glu Glu Ile Arg Ser  His Glu Leu Leu Lys  Glu Ile Gln 
    1010                 1015                 1020             


Asn Leu  Glu Gln Tyr Ile Tyr  Asp His Thr Thr Asp  Lys Asn Thr 
    1025                 1030                 1035             


Leu Leu  Gln Asp Gly Asn Pro  Asn Phe Lys Met Tyr  Val Leu Asn 
    1040                 1045                 1050             


Gly Leu  Leu Thr Gly Ile Lys  Gln Val Asn Ile Ala  Asp Phe Ile 
    1055                 1060                 1065             


Val Leu  Lys Gln Asn Thr Asn  Phe Asp Lys Ile Asp  Phe Thr Gly 
    1070                 1075                 1080             


Ile Ala  Ser Cys Ser Glu Leu  Glu Lys Lys Thr Ile  Ile Leu Ile 
    1085                 1090                 1095             


Ala Ile  Arg Asn Lys Phe Ala  His Asn Gln Leu Pro  Asn Lys Thr 
    1100                 1105                 1110             


Ile Tyr  Asp Leu Ala Asn Glu  Phe Leu Lys Lys Glu  Lys Arg Glu 
    1115                 1120                 1125             


Thr Tyr  Ala Asn Tyr Tyr Leu  Lys Val Leu Lys Lys  Met Ile Ser 
    1130                 1135                 1140             


Asp Leu  Ala 
    1145     


<210>  2354
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2354

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2355
<211>  1137
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2355

Met Glu Asn Asn Thr Thr Leu Gly Lys Gly Ile Ser Tyr Asn Pro Tyr 
1               5                   10                  15      


Lys Thr Ala Asp Lys His Tyr Phe Gly Gly Tyr Phe Asn Leu Ala Met 
            20                  25                  30          


Asn Asn Ile Glu Phe Val Ile Ala Glu Phe Leu Thr Arg Ile Gly Arg 
        35                  40                  45              


Lys Glu Thr Lys Ile Ala Asn Leu Lys Lys Val Phe Thr Glu Asn Met 
    50                  55                  60                  


Ser Leu Val Asp Tyr Glu Arg Tyr Ile His Ile Leu Glu Glu Tyr Phe 
65                  70                  75                  80  


Pro Ile Ile Lys His Leu Asp Lys Ile His Phe Lys Ile Asn Asp Thr 
                85                  90                  95      


Val Lys Glu Val Ser Lys Glu Lys Arg Ile Thr Tyr Phe Ile Asp Asn 
            100                 105                 110         


Phe Ile Ser Leu Leu Asp Leu Thr Asn Asn Leu Arg Asn Phe Tyr Thr 
        115                 120                 125             


His Tyr Tyr His Glu Ser Ile Ala Ile Glu Glu Asn Ile Phe Asp Phe 
    130                 135                 140                 


Leu Asp Glu Ser Leu Leu Thr Thr Val Arg Asp Thr Lys Glu Asn Tyr 
145                 150                 155                 160 


Leu Lys Ser Asp Lys Thr Lys Gln Ile Leu Ser Ile Ser Leu Lys Gln 
                165                 170                 175     


Glu Leu Glu Ile Leu Cys Ser Glu Lys Leu Asn Tyr Leu Lys Glu Asn 
            180                 185                 190         


Lys Ile Lys Phe Asn Arg Asn Asp Lys Glu Ala Leu Ile Asn Ala Val 
        195                 200                 205             


Tyr Asn Asp Ala Phe Lys Asn Phe Leu Tyr Lys Lys Gly Glu His Phe 
    210                 215                 220                 


His Leu Thr Asp Tyr Lys Lys Thr Lys Ile Leu Asn Pro Asp Lys Leu 
225                 230                 235                 240 


Glu Lys Asp Phe Asp Leu Asp Leu Ser Thr Ser Gly Ile Val Tyr Leu 
                245                 250                 255     


Leu Ser Phe Phe Leu Asn Arg Lys Glu Leu Glu Leu Phe Lys Gly Asn 
            260                 265                 270         


Ile Lys Gly Phe Lys Ala Ser Val Ile Arg Gly Thr Ser Asp Phe Glu 
        275                 280                 285             


Lys Asn Ser Ile His Phe Met Ala Thr His Arg Ile Tyr Ser Val His 
    290                 295                 300                 


Cys Tyr Arg Gly Leu Lys Lys Lys Ile Arg Ser Ser Asn His Asp Thr 
305                 310                 315                 320 


Lys Gln Val Leu Leu Met Gln Met Leu Asp Glu Leu Ser Lys Val Pro 
                325                 330                 335     


His Val Ile Tyr Asn Ser Leu Asp Lys Glu Leu Lys Asp Thr Phe Val 
            340                 345                 350         


Glu Asp Trp Asn Glu Tyr Phe Lys Asp Asn Glu Glu Asn Asn Glu Asn 
        355                 360                 365             


Leu Glu Asn Ser Arg Val Ile His Pro Val Ile Arg Lys Arg Tyr Glu 
    370                 375                 380                 


Asp Lys Phe Asn Tyr Phe Ala Leu Arg Phe Leu Asp Asn Cys Val Asp 
385                 390                 395                 400 


Phe Pro Thr Leu Arg Phe Gln Val His Val Gly Asp Tyr Val His His 
                405                 410                 415     


Lys Met Glu Lys Ser Leu Ile Asp Ser Lys Ile Ile Ser Glu Arg Ile 
            420                 425                 430         


Ile Lys Glu Lys Val Thr Val Phe Ala Arg Leu Asp Glu Val Asn Lys 
        435                 440                 445             


Ala Lys Ala Asp Tyr Phe Asn Ser Leu Gln Ala Glu Asn Asp Asn Arg 
    450                 455                 460                 


Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asp Phe Pro Lys Gln Asn Thr 
465                 470                 475                 480 


Glu Lys Ile Met Gly Asn Ala Lys Gln Lys Asn Ala Glu Lys Ile Gly 
                485                 490                 495     


Ile Tyr Ile Gln Leu Lys Asn Ser Asn Leu Ile Gln Gln Thr Ala Asp 
            500                 505                 510         


Ala Lys Glu Lys Leu Asn Pro His Lys Arg Ser Asn Thr Lys Leu Arg 
        515                 520                 525             


Lys Gln Glu Ile Ile Glu Lys Ile Ile Asn Leu Asn Thr Asp Tyr Lys 
    530                 535                 540                 


Ser Lys Thr Pro Ile Val His Thr Gly Glu Pro Val Ala Tyr Leu Ser 
545                 550                 555                 560 


Thr His Asp Leu His Ser Ile Leu Tyr Asp Leu Leu Ile Lys Gly Glu 
                565                 570                 575     


Thr Ala Gln Ala Val Glu Met Lys Ile Gln Lys Gln Ile Glu Lys Gln 
            580                 585                 590         


Leu Arg Glu Ile Val Asp Lys Asp Thr Ser Val Lys Ile Leu Lys Lys 
        595                 600                 605             


Tyr Asn Lys Glu Gln Thr Phe Ser Asn Ile Asn Phe Ser Lys Leu Gln 
    610                 615                 620                 


Asn Asp Leu Val Lys Glu Arg Asp Asn Leu Ile Ser Leu Leu Asp Glu 
625                 630                 635                 640 


His Asp Tyr Arg Ile Glu Asp Tyr Asp Arg Thr Lys Lys Gln Arg Asn 
                645                 650                 655     


Tyr Pro His Lys Arg Thr Tyr Ile Leu Tyr Ala Ala Glu Lys Gly Lys 
            660                 665                 670         


Ile Ala Ala Trp Leu Ala Asp Asp Ile Lys Arg Phe Met Pro Lys Asp 
        675                 680                 685             


Phe Lys Glu Gln Trp Lys Gly Tyr Gln His Ser Glu Leu Gln Lys Leu 
    690                 695                 700                 


Leu Ala Tyr Tyr Asp Thr Asn Asn Lys Leu Ile Ala Glu Leu Leu Lys 
705                 710                 715                 720 


Gly Leu Asp Ile Glu Asn Leu Pro Phe Asp Leu Asn Asn Cys Leu Lys 
                725                 730                 735     


Lys Asn Thr Leu Glu Asp Phe Tyr Pro Met Tyr Leu Glu Lys Arg Ile 
            740                 745                 750         


Gly Tyr Ile Ser Gln Leu Ile Glu Gln Ile Lys Asn Phe Lys Asp Glu 
        755                 760                 765             


Pro Lys Leu Leu Lys Lys Val Leu Asn Glu Cys Phe Lys Phe Leu Lys 
    770                 775                 780                 


Glu Lys Asn Tyr Lys Gln Cys Gly Leu Asn Asp Gln Val Gln Arg Leu 
785                 790                 795                 800 


Leu Ala Met Pro Val Phe Ile Glu Arg Gly Phe Leu Asp Glu Lys Pro 
                805                 810                 815     


Thr Met Lys Pro Asn Ile Ser Phe Asp Asp Asn Lys Glu Asp Phe Ala 
            820                 825                 830         


Glu Trp Phe Val Tyr Tyr Lys Ser Lys Asn Asn Tyr Gln Lys Phe Tyr 
        835                 840                 845             


Asp Val Glu Leu Tyr Pro Phe Leu Tyr Asn Asp Lys Lys Glu Leu Tyr 
    850                 855                 860                 


Lys Ile Gln Thr Lys Ile Lys Arg Gln Gln Lys Asn Asp Val Phe Thr 
865                 870                 875                 880 


Leu Leu Met Ser Lys Glu Leu Phe Thr Glu Ile Phe Arg Glu Glu Ala 
                885                 890                 895     


Asn Phe Thr Leu Gly Glu Leu Phe Gln Ser Arg Glu Glu Arg Leu Lys 
            900                 905                 910         


Asn Ala Gln Asn Ala Lys Glu Thr Gln Glu Arg Asn Leu Asn Phe Ile 
        915                 920                 925             


Trp Asn Lys Val Val Asn Leu Asn Leu Ala Asn Gly Lys Ile Asn Ile 
    930                 935                 940                 


Ser Asp Val Lys Leu Lys Asp Ile Gly Asn Phe Lys Ala Tyr Glu Thr 
945                 950                 955                 960 


Asp Gln Arg Val Ile Ser Phe Leu Glu Tyr Glu Thr Asn Lys Lys Trp 
                965                 970                 975     


Leu Ala Tyr Leu Pro Asn Asn Val Ser Lys Glu Asn Thr Ala Leu Asp 
            980                 985                 990         


Val Ile Glu Cys Gln Leu Gln Asn  Tyr Glu Lys Val Arg  Ala His Gln 
        995                 1000                 1005             


Leu Phe  Lys Glu Val Gln Lys  Leu Glu Gln Tyr Ile  Tyr His Lys 
    1010                 1015                 1020             


Val Glu  Asn Lys Glu Val Leu  Lys His Lys Gly Asn  Gln Asn Phe 
    1025                 1030                 1035             


Arg Asn  Tyr Leu Leu Tyr Gly  Leu Tyr Asp Arg Asp  Leu Ser Gln 
    1040                 1045                 1050             


Glu Phe  Val Val Ile Lys Ser  Glu Asn Phe Glu Asn  Ile Ser Ile 
    1055                 1060                 1065             


Lys Glu  Ile Lys Glu Lys Ala  Ala Lys Leu Glu Gln  Gln Leu Phe 
    1070                 1075                 1080             


Ile Leu  Thr Tyr Ile Arg Asn  Lys Phe Ala His Asn  Gln Met Pro 
    1085                 1090                 1095             


Asn Lys  Glu Phe Tyr Asp Phe  Cys Gln Glu Ile Val  Pro Cys Glu 
    1100                 1105                 1110             


Asn Thr  Asn Gln Phe Tyr Ala  Asp Tyr Tyr Leu Met  Val Phe Ser 
    1115                 1120                 1125             


Ser Ile  Val Asn Glu Leu Ser  Ile Asn 
    1130                 1135         


<210>  2356
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2356

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Lys Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Leu Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2357
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2357

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Lys Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Leu Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2358
<211>  1251
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2358

Met Gln Ser Lys Ser Leu Glu Asn Lys Pro Val Phe Ala Ala Tyr Leu 
1               5                   10                  15      


Asn Met Ala Arg Gln Asn Ala Phe Glu Thr Leu Cys His Ile Ser Arg 
            20                  25                  30          


Leu Met Gly Ile Glu Val Asp Asp Ala Glu Lys Glu Lys Glu Asn Arg 
        35                  40                  45              


Leu Trp Glu Met Lys Val Val Lys Glu Leu Ser Val Glu Glu Ile Lys 
    50                  55                  60                  


Ser Val Arg Lys Leu Lys Leu Ile Lys Leu Phe His Thr His Phe Pro 
65                  70                  75                  80  


Phe Leu Lys Pro Ile Leu Asp Val Glu Gln Arg Ser Pro Lys Gly Tyr 
                85                  90                  95      


Ile Pro Thr Glu Leu Asp Glu Asp Pro Ser Glu Glu Gln Ile Glu Lys 
            100                 105                 110         


Glu Leu Asn Thr Lys Ile Val Tyr Ala Ser Pro Leu Lys Tyr Tyr Ala 
        115                 120                 125             


Ile Leu Glu Asn Met Phe Arg Leu Leu Asn Ala Leu Arg Asn Glu Tyr 
    130                 135                 140                 


Thr His Ala Ser Pro Glu Glu Val Pro Leu Pro Glu Lys Lys Lys Leu 
145                 150                 155                 160 


His Glu Asn Val Val Arg Tyr Ala Tyr Asn Cys Leu Asp Gly Gly Arg 
                165                 170                 175     


Arg Val Val Lys Gln Arg Phe Gly Asn Phe Glu Leu Pro Ala Asp Lys 
            180                 185                 190         


Asp Ala Phe Ala Phe Leu Thr Asp Met Asn Val Arg Tyr Asp Lys Val 
        195                 200                 205             


Lys Ile Pro Gly Lys Phe Lys Ile Ile Lys Lys Lys Gly Lys Glu Gln 
    210                 215                 220                 


Lys Val Gln Glu Ser Lys Phe Val Glu Lys Ser Asn Phe Pro Tyr Arg 
225                 230                 235                 240 


Met Lys Asp Glu Gln Gly Ile Leu Ser Asp Val Gly Ile Leu Leu Phe 
                245                 250                 255     


Val Cys Leu Phe Leu His Lys Lys Tyr Ile Ser Met Phe Met Asp Lys 
            260                 265                 270         


Val Lys Pro Tyr Arg Glu Gly Ala Asp Asn Val Glu Gln Lys Val Leu 
        275                 280                 285             


Leu Glu Thr Phe Ser Val Phe Arg Ile Arg Leu Pro Lys Glu Arg Tyr 
    290                 295                 300                 


Asp Ser Glu Arg Pro Asp Tyr Ala Leu Gly Leu Asp Met Leu Asn Glu 
305                 310                 315                 320 


Leu Gln Lys Cys Pro Lys Glu Leu Tyr Glu Thr Phe Ala Glu Ser Asp 
                325                 330                 335     


Lys Ala Lys Phe Arg Val Pro Ile Lys Ser Thr Ser Glu Asp Val Val 
            340                 345                 350         


Met Asp Asp Gly Val Ile Val Glu Asn Gly Glu Val Leu Gln Ile Arg 
        355                 360                 365             


Val Gln Asp Arg Phe Pro Thr Met Ala Leu Arg Tyr Ile Asp Gln Thr 
    370                 375                 380                 


Gln Ala Phe Pro Lys Ile Arg Phe Gln Val Ser Leu Gly His Tyr Arg 
385                 390                 395                 400 


Tyr Ser Phe Tyr Asp Lys Glu Cys Ile Asp Ser Lys Asn Lys Glu Lys 
                405                 410                 415     


Asp Arg Val Arg Val Leu Gln Lys Glu Ile Asn Gly Phe Gly Arg Leu 
            420                 425                 430         


Asn Glu Ile Glu Leu Lys Arg Lys Glu Met Tyr Ala Ser His Ile Arg 
        435                 440                 445             


Thr Asn Asp Val Val Arg Lys Asp Thr Ala Asp Ser Glu Pro Tyr Ile 
    450                 455                 460                 


Thr Asp Cys Tyr Ala Asn Tyr Val Phe Asn Gly Asn Arg Ile Gly Phe 
465                 470                 475                 480 


Leu Phe Phe Asp Lys Asp Leu Gly Arg Thr Glu Ile Lys Ser Met Asn 
                485                 490                 495     


Thr Ala Glu Asp Lys Glu Ile Met Tyr Ile Pro Glu Leu Glu Phe Asp 
            500                 505                 510         


Lys Asp Leu Ala Lys Glu Thr Lys Lys Asn Gly Thr Asn Ala Val Cys 
        515                 520                 525             


Val Pro Pro Ile Ala Trp Leu Ser Thr Tyr Glu Leu Pro Ala Leu Val 
    530                 535                 540                 


Phe His His His Leu Cys Gln Arg Leu Asn Leu Val Ser Pro Asp Lys 
545                 550                 555                 560 


Lys Ile Ser Lys Asn Pro Thr Glu Tyr Val Ile Ile Gln Cys Ile Lys 
                565                 570                 575     


Thr Tyr Tyr Arg Phe Phe Asn Asp Val Lys Glu Gly Arg Leu His Pro 
            580                 585                 590         


Glu Met Ile Lys Asp Lys Glu Ser Leu Ala Ala Leu Ile Arg Lys Asp 
        595                 600                 605             


Tyr Ala Pro Leu Gln Leu Lys Asp Ile Pro Val Lys Leu Val Asp Tyr 
    610                 615                 620                 


Leu Thr Lys Val Lys Val Asn Met Gly Glu Val Phe Lys Thr Arg Ala 
625                 630                 635                 640 


Lys Glu Arg Met Glu Lys Met Leu Arg Gly Thr Glu Val Arg Leu Lys 
                645                 650                 655     


Met Phe Arg Glu Glu Arg Ala Lys Ile Gly Ala Lys Asp Asn Lys Phe 
            660                 665                 670         


Gly Lys Lys Ser Tyr Val Asp Ile Arg Pro Gly Lys Leu Ala Glu Tyr 
        675                 680                 685             


Leu Ala Lys Asp Met Leu Met Phe Gln Pro Val Asp Lys Asp Asn Lys 
    690                 695                 700                 


Asn Lys Val Thr Gly Leu Asn Phe Gln Val Ile Gln Ala Ser Leu Ala 
705                 710                 715                 720 


Ile Tyr Asp Lys Thr Trp Asp Glu Leu Arg Thr Ile Phe Glu Asn Ala 
                725                 730                 735     


Lys Leu Ile Asp Pro Gln Asn Thr Ile Asn Lys Asn Leu Asn His Pro 
            740                 745                 750         


Phe Leu Lys Lys Leu Phe Asp Ser Lys Lys Ile Pro Leu Asn Thr Met 
        755                 760                 765             


Asp Phe Tyr Glu Arg Tyr Leu Gln Glu Lys Ile Asp Tyr Leu Lys Asp 
    770                 775                 780                 


Arg Leu Ser Lys Gly Lys Phe Ser Glu Ala Phe Leu His Lys Asp Arg 
785                 790                 795                 800 


Met Lys Trp Arg Lys Arg Asp Ala Asp Tyr Tyr Lys Ala Leu Ala Gly 
                805                 810                 815     


Arg Tyr Leu Glu Asp Met Leu Asp Asp Asn Arg Lys Asn Leu Lys Pro 
            820                 825                 830         


Ile Glu Leu Pro Arg Gly Leu Phe Glu Arg Ser Ile Val Asp Ile Leu 
        835                 840                 845             


Lys Asp Ala Tyr Ala Asp Glu Ser Gln Asp Thr Tyr Lys Lys Asp Leu 
    850                 855                 860                 


Ala Ala Phe Val Lys Glu Gln Met Phe Ala Tyr Glu Lys Gly Glu Gln 
865                 870                 875                 880 


Pro Pro Tyr Asn Thr Ser Phe Phe Ile Ser Ala Tyr Phe Thr His Val 
                885                 890                 895     


Ser Lys Asp Lys Val Gln Pro Phe Tyr Thr Ser Thr Ser Asn Thr Tyr 
            900                 905                 910         


Lys Arg Thr Tyr Lys Phe Phe Asn Met Ile Asn Asn Glu Ile Lys Arg 
        915                 920                 925             


Asn Ala Leu Ile Ala Gln Tyr Tyr Thr Gln Glu Glu Phe Lys Val Leu 
    930                 935                 940                 


Arg Lys Lys Tyr Lys Leu Thr Gly Lys Pro Asp Ala Lys Leu Ala Gln 
945                 950                 955                 960 


Tyr Lys Lys Asp Ala Phe Asp Lys Glu Lys Lys Lys Pro Glu Ser Arg 
                965                 970                 975     


Gly Lys Ser Asn Glu Glu Ile Arg Asn Ile Ile Asp Ser Arg Leu Arg 
            980                 985                 990         


Lys Tyr His Tyr Glu Tyr Asp Asp  Asn Glu Arg Ala Ile  Arg Arg Phe 
        995                 1000                 1005             


Met Val  Gln Asp Ile Leu Val  Phe Leu Met Ala Lys  Asp Leu Leu 
    1010                 1015                 1020             


Leu Lys  Asn Ile Gly Lys Asp  Asp Val Lys Gly Lys  Thr Arg Asp 
    1025                 1030                 1035             


Lys Ile  Glu Gln Tyr Lys Leu  Gln Asn Ile Asn Pro  Thr Ser Asp 
    1040                 1045                 1050             


Thr Gly  Asn Ile Leu Ser Leu  Ser Ile Pro Phe Ser  Leu Thr Leu 
    1055                 1060                 1065             


Thr Leu  Lys Asp Gly Ser Thr  Arg Thr Ile Thr Gln  Gln Glu Leu 
    1070                 1075                 1080             


Lys Leu  Lys Asn Tyr Gly Asp  Phe Phe Arg Phe Val  Tyr Asp Glu 
    1085                 1090                 1095             


Arg Leu  Ala Thr Leu Leu Ser  Gln Thr Lys Ser Val  Glu Ile Asn 
    1100                 1105                 1110             


Arg Asp  Asp Leu Glu Lys Glu  Leu Leu His Tyr Asp  Leu Gln Arg 
    1115                 1120                 1125             


Thr Lys  Ile Phe Gly Trp Val  His Ala Met Glu Asn  Tyr Leu Phe 
    1130                 1135                 1140             


Lys Gln  His Pro Glu Leu Gly  Lys Lys Asp Lys Met  Glu Glu Gly 
    1145                 1150                 1155             


Ser His  Tyr Tyr Tyr Ala Gln  Lys Val Lys Asn Lys  Lys Thr Gly 
    1160                 1165                 1170             


Glu Glu  Glu Thr Lys Tyr Ser  Pro Phe Arg Gln Asn  Phe Arg Ala 
    1175                 1180                 1185             


Met Leu  Asn Val Pro Gly Asn  Ile Pro Ser Arg His  Leu Glu Ala 
    1190                 1195                 1200             


Met Val  Gly Ile Arg Asn Ser  Phe Cys His Asn His  Tyr Val Glu 
    1205                 1210                 1215             


Asp Leu  Asn Phe Gly Gly Tyr  Gln Ser Ala Asp Ile  Pro Lys Leu 
    1220                 1225                 1230             


Ala Asp  Ala Leu Glu Lys Ile  Leu Lys Glu Leu Val  Glu Gln His 
    1235                 1240                 1245             


Ser Lys  Lys 
    1250     


<210>  2359
<211>  1160
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2359

Met Glu Gln Lys Gln Leu Glu Ser Arg Phe Asn Gln Ile Phe Asn Asn 
1               5                   10                  15      


Lys Gly His Thr Gly Pro Ile Ala Glu Lys Ala Val Lys Asn Phe Glu 
            20                  25                  30          


Thr Ile Arg Gln His Lys Val Ser Pro Arg Glu Arg Leu His Tyr Phe 
        35                  40                  45              


Ala Val Gly His Ala Leu Arg Asn Ile Asp Lys Asp Leu Lys Glu Ser 
    50                  55                  60                  


Ile Phe Glu Tyr Asn Leu Asp Glu Glu Gln Lys Lys Gln Lys Pro Thr 
65                  70                  75                  80  


Gln Phe Thr Thr Leu Gln Ser Asp Phe Phe Arg Phe Glu Asn Ala Leu 
                85                  90                  95      


Leu Thr Leu Leu Lys Asp Ile Arg Asn Cys Asn Gly His Tyr Val His 
            100                 105                 110         


Thr Phe Asp Lys Leu Gln Leu Asp Glu Ile Leu Lys Leu Gln Glu Lys 
        115                 120                 125             


Asn Lys Glu His Gly Ile Leu Asn Lys Asp Ala Gly Cys Gln Ile Ile 
    130                 135                 140                 


Glu Phe Leu Lys Glu Ala Phe Glu Phe Ser Ile Leu Ile Gln Phe Leu 
145                 150                 155                 160 


Lys Glu Lys Pro Lys Glu Tyr Glu Lys Phe Lys Lys Arg Lys Asn Glu 
                165                 170                 175     


Asn Lys Asn Gln Ser Leu Arg Asn Leu Ile Gly Gly Tyr Glu Lys Lys 
            180                 185                 190         


Leu Val Lys Tyr Leu Cys Asp Lys Phe Phe Pro Asn Glu Glu Lys Gln 
        195                 200                 205             


Lys Glu Ile Arg Asp Lys Phe Ile Glu His Asn Leu Glu Glu Ala Ile 
    210                 215                 220                 


Glu Asp Leu Leu Phe Ile Pro Val Asp Glu Asp Ile Glu Trp Lys Leu 
225                 230                 235                 240 


Gly Glu Glu His Val Val Phe Val Ile Lys Lys Gly Lys Tyr Leu Ser 
                245                 250                 255     


Phe Tyr Ala Gln Leu Phe Leu Leu Ser Met Phe Leu Tyr Lys Gln Glu 
            260                 265                 270         


Ala Asn Gln Leu Ile Ser Lys Ile Arg Gly Phe Lys Arg Ser Glu Asp 
        275                 280                 285             


Glu Phe Gln Tyr Lys Arg Asn Ile Phe Thr Phe Phe Ser Lys Lys Val 
    290                 295                 300                 


Ser Ser Gln Asp Ile His Ser Glu Glu Lys His Leu Ile Tyr Phe Arg 
305                 310                 315                 320 


Asp Ile Ile Gln Tyr Leu Asn Arg Phe Pro Thr Ala Trp Asn Glu Tyr 
                325                 330                 335     


Leu Ser Pro Glu Arg Lys Asn Leu Pro Met Thr Lys Leu Leu Glu Lys 
            340                 345                 350         


Tyr Ile Leu Glu Glu Glu Ile Phe Arg Thr Phe Ser Thr Tyr Lys Asn 
        355                 360                 365             


Asp Cys Asn Arg Glu Leu Phe Leu Lys Tyr Thr Ile Lys Arg Leu Phe 
    370                 375                 380                 


Cys Lys Lys Ala Glu Leu Phe Asp Ala Glu Lys Ile Ser Ile Asp Asp 
385                 390                 395                 400 


Asn Leu Arg Lys Lys Phe Asn Tyr Glu Ile Asp Thr Ser Pro Glu Leu 
                405                 410                 415     


Lys Asn Ile His Glu Lys Leu Lys Gly Lys Leu Lys Pro Lys Asp Tyr 
            420                 425                 430         


Tyr Lys Asn Ile Lys Arg Lys Glu Glu Leu Glu Lys Glu Glu Asn Pro 
        435                 440                 445             


Glu Lys Leu Lys Leu Thr Lys Lys Val Thr Glu Glu Lys Leu Phe Thr 
    450                 455                 460                 


Ala Tyr Gly Arg Asn Arg Asp Arg Phe Met Asp Phe Ala Val Arg Tyr 
465                 470                 475                 480 


Leu Ala Glu Gln Asn Tyr Phe Gly Lys Asp Ala Glu Phe Lys Met Tyr 
                485                 490                 495     


Met Phe Glu Thr Thr Asn Glu Gln Glu Asn Tyr Leu Lys Glu Gln Lys 
            500                 505                 510         


Asn Thr Ala Asp Lys Lys Val Ile Asp Gln Asn Lys Tyr His Gln Gly 
        515                 520                 525             


Arg Leu Thr Cys Phe Lys Thr Tyr Gln Lys His Lys Asp Asp Tyr Gln 
    530                 535                 540                 


Asn Trp Asp Asp Pro Phe Val Phe Gln Asn Asn Ala Phe Gln Ile Ile 
545                 550                 555                 560 


Leu Thr Phe Ser Asn Gly Glu Arg Lys Lys Phe Ser Ile Gln Arg Lys 
                565                 570                 575     


Leu Leu Ile Tyr Leu Leu Glu Asp Ala Leu Phe Asn His Ser Asp Ser 
            580                 585                 590         


Ile Glu Asp Lys Gly Lys Gln Leu Leu Glu Asp Tyr Phe Phe Asn Thr 
        595                 600                 605             


Leu Met Pro Asp Phe Glu Asp Ala Lys Glu Ser Tyr Lys Thr Ser Asp 
    610                 615                 620                 


Asp Val Asn Trp Lys His Arg Lys Leu Leu Pro Lys Arg Leu Ile Tyr 
625                 630                 635                 640 


Thr Val His Pro Pro Arg Arg Thr Asp Ser Glu Glu Gln Ile His Pro 
                645                 650                 655     


Phe Glu Lys Ile Leu Arg Glu Thr Gln Glu Gln Glu Arg Arg Tyr Arg 
            660                 665                 670         


Leu Leu Leu Gly Lys Ala Lys Asn Met Lys Leu Lys Glu Glu Phe Ile 
        675                 680                 685             


Lys Arg Asn Lys Gly Lys His Phe Lys Leu Arg Phe Ile Arg Lys Ala 
    690                 695                 700                 


Trp His Leu Met Tyr Phe Arg Glu Ile Tyr Glu Arg Arg Ala Lys Glu 
705                 710                 715                 720 


His Ser His His Lys Ser Phe His Ile Thr Arg Asp Glu Ile Asn Asp 
                725                 730                 735     


Phe Ser Arg Trp Met Tyr Ala Phe Asp Glu Val Pro Pro Tyr Lys Val 
            740                 745                 750         


Tyr Leu Arg Asn Met Leu Gln Arg Lys Lys Phe Met Glu Asn Glu Glu 
        755                 760                 765             


Phe Ala Glu Leu Phe Glu Lys Gly Lys Ser Leu Asp Asp Phe Tyr Arg 
    770                 775                 780                 


Ile Thr Lys Lys Glu Phe Ser Lys Arg Ile Lys Asn Asn Leu Phe Gln 
785                 790                 795                 800 


Leu Lys Val Asp Ser Glu Arg Gln Tyr Ala Glu Ile Leu Ser Lys Lys 
                805                 810                 815     


Leu Val Tyr Ile Asn Leu Ser His Phe Ile Lys Tyr Leu Asn Ala Lys 
            820                 825                 830         


Gly Lys Leu Thr Val Glu Asn Gly Ile Ile Gln Tyr Lys Ala Ser Thr 
        835                 840                 845             


Asn Lys Lys Tyr Leu Ile Asp Glu Tyr Tyr Tyr Thr Glu Val Leu Pro 
    850                 855                 860                 


Arg Glu Glu Tyr Lys Val His Lys His Leu Phe Asn Lys Leu Arg Ala 
865                 870                 875                 880 


Thr Lys Leu Glu Asp Ala Leu Leu Tyr Glu Leu Ala Met Lys Tyr Leu 
                885                 890                 895     


Arg Glu Asp Asn Asp Ile Val Glu Lys Ala Lys Ser Lys Val Ser Asp 
            900                 905                 910         


Ile Gln Ser Ser Glu Ile Ser Phe Asp Ile Lys Asp Tyr Tyr Gly Asn 
        915                 920                 925             


His Leu Tyr Thr Leu Ile Val Pro Phe Asn Lys Leu Glu Thr Leu Ser 
    930                 935                 940                 


Ile Leu Ile Arg Tyr Lys Thr Lys Gln Glu Lys Asn Ser Lys Leu Gln 
945                 950                 955                 960 


Arg Thr Ser Phe Leu Gly Asn Ile Tyr His Leu Leu Ala Phe Leu Asp 
                965                 970                 975     


Lys Asn Tyr Lys Gln Leu Ser Lys Tyr Lys Asp Asp Gly Gly Phe Lys 
            980                 985                 990         


Lys Ile Val Lys Asn Phe Lys Asn  Lys Lys Arg Leu Ser  Phe Val Glu 
        995                 1000                 1005             


Leu Asn  Thr Ile Asn Gly Tyr  Ile Ile Ser Gly Ala  Val Lys Phe 
    1010                 1015                 1020             


Ser Lys  Val His Met Glu Leu  Glu Arg Tyr Phe Ile  Asn Lys His 
    1025                 1030                 1035             


Lys Ile  Lys Ala Asn His Ile  Tyr Ile Asp Leu Glu  Asp Ile Lys 
    1040                 1045                 1050             


Asp Asp  Ser Asn Lys Gln Val  Phe Gly Asn Tyr Tyr  Asp Ser Lys 
    1055                 1060                 1065             


Leu Arg  Ile Arg Asn Lys Ala  Phe His Phe Gly Val  Pro Thr Asn 
    1070                 1075                 1080             


Phe Phe  Phe Asn Ile Glu Ile  Glu Lys Ile Glu Lys  Lys Phe Ile 
    1085                 1090                 1095             


Leu Glu  Glu Val Lys Leu Gln  Asn Val Ser Ser Phe  Asp Lys Leu 
    1100                 1105                 1110             


Asn Gln  Asn Ala Lys Ser Val  Cys Arg Val Phe Met  Glu Val Leu 
    1115                 1120                 1125             


His Ser  Asp Leu Tyr Arg Arg  Asp Lys Asn Lys Ser  Lys Glu Glu 
    1130                 1135                 1140             


Leu Arg  Arg Glu Phe Glu Glu  Lys Tyr Phe Asn Glu  Ile Ile Thr 
    1145                 1150                 1155             


Thr Val  
    1160 


<210>  2360
<211>  1146
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2360

Met Glu Ser Ile Ile Gly Leu Gly Leu Ser Phe Asn Pro Tyr Lys Thr 
1               5                   10                  15      


Ala Asp Lys His Tyr Phe Gly Ser Phe Leu Asn Leu Ala Asp Asn Asn 
            20                  25                  30          


Leu Lys Ala Val Phe Ala Glu Phe Lys Glu Arg Ile Ser Asp Lys Ser 
        35                  40                  45              


Lys Asp Glu Asp Ile Ser Asn Leu Ile Glu Lys His Phe Ile Asp Asn 
    50                  55                  60                  


Met Ser Ile Val Asp Tyr Glu Lys Asn Ile Ser Ile Leu Asn Gly Tyr 
65                  70                  75                  80  


Leu Pro Ile Ile Asp Phe Leu Asp Asp Glu Leu Glu Asn Asn Leu Asn 
                85                  90                  95      


Thr Arg Val Lys Asn Phe Lys Lys Ser Phe Ile Ile Leu Ala Glu Ala 
            100                 105                 110         


Leu Glu Thr Leu Arg Asn Tyr Tyr Thr His Phe Tyr His Asp Pro Ile 
        115                 120                 125             


Thr Phe Gly Asp Asn Lys Glu Pro Leu Leu Glu Leu Leu Asp Glu Val 
    130                 135                 140                 


Leu Leu Lys Thr Ile Leu Asp Val Lys Lys Lys Tyr Leu Lys Thr Asp 
145                 150                 155                 160 


Lys Thr Lys Glu Ile Leu Lys Asp Ser Leu Arg Glu Glu Met Asp Leu 
                165                 170                 175     


Leu Val Ile Arg Lys Thr Asp Glu Leu Arg Glu Lys Lys Lys Thr Asn 
            180                 185                 190         


Pro Lys Phe Lys Phe Ser Thr Asp Pro Thr Gln Ile Arg Asn Ser Ile 
        195                 200                 205             


Phe Asn Asp Ala Phe Gln Gly Leu Leu Tyr Glu Asp Lys Glu Asn Asn 
    210                 215                 220                 


Gly Lys Thr Gln Val Ser Tyr Arg Ala Lys Thr Lys Leu Asn Pro Lys 
225                 230                 235                 240 


Asp Ile His Lys Gln Glu Glu Arg Asp Phe Glu Ile Pro Leu Ser Thr 
                245                 250                 255     


Ser Gly Ile Val Phe Leu Met Ser Leu Phe Leu Ser Lys Lys Glu Ile 
            260                 265                 270         


Glu Asp Phe Lys Ser Asn Ile Lys Gly Phe Lys Gly Lys Val Val Lys 
        275                 280                 285             


Asp Glu Asn His Asn Ser Leu Lys Tyr Met Ala Thr His Arg Val Tyr 
    290                 295                 300                 


Ser Ile Leu Ala Phe Lys Gly Leu Lys Tyr Arg Ile Lys Thr Asp Thr 
305                 310                 315                 320 


Phe Ser Lys Val Thr Leu Met Met Gln Met Ile Asp Glu Leu Ser Lys 
                325                 330                 335     


Val Pro Asp Cys Val Tyr Gln Asn Leu Ser Glu Thr Lys Gln Lys Asp 
            340                 345                 350         


Phe Ile Glu Asp Trp Asn Glu Tyr Leu Lys Asp Asn Glu Glu Asn Thr 
        355                 360                 365             


Glu Asn Leu Glu Asn Ser Arg Val Val His Pro Leu Ile Arg Lys Arg 
    370                 375                 380                 


Tyr Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe 
385                 390                 395                 400 


Ala Asn Phe Lys Thr Leu Lys Phe Gln Val Phe Met Gly Tyr Tyr Ile 
                405                 410                 415     


His Asp Gln Arg Thr Lys Thr Ile Gly Thr Thr Asn Ile Thr Thr Glu 
            420                 425                 430         


Arg Thr Val Lys Glu Lys Ile Asn Val Phe Gly Lys Leu Ser Lys Met 
        435                 440                 445             


Asp Asn Leu Lys Lys His Phe Phe Ser Gln Leu Ser Asp Glu Glu Asn 
    450                 455                 460                 


Thr Asp Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Phe Leu Thr Gln 
465                 470                 475                 480 


Ala Asp Asn Ser Pro Ala Asn Asn Ile Pro Ile Tyr Leu Glu Leu Lys 
                485                 490                 495     


Asn Gln Gln Ile Ile Lys Glu Lys Asp Asp Ile Lys Ala Glu Val Asn 
            500                 505                 510         


Asn Ser Gln Asn Arg Asn Pro Asn Lys Pro Ser Lys Arg Asp Leu Leu 
        515                 520                 525             


Asn Lys Ile Ser Asn Thr Asn Glu Asp Phe Tyr Gln Gly Asp Pro Thr 
    530                 535                 540                 


Ala Ile Leu Ser Leu Asn Glu Ile Pro Ala Leu Leu His Leu Phe Leu 
545                 550                 555                 560 


Val Gln Pro Asp Asn Lys Thr Gly Gln Gln Ile Glu Asn Ile Ile Arg 
                565                 570                 575     


Ile Lys Ile Glu Lys Gln Phe Asn Ser Ile Lys Asn Pro Ser Lys Asp 
            580                 585                 590         


Asp Lys Gly Val Pro Lys Ser Leu Phe Ala Asp Thr Asn Val Arg Val 
        595                 600                 605             


Asn Ala Ile Lys Leu Lys Lys Asp Leu Gly Glu Glu Leu Asp Met Leu 
    610                 615                 620                 


Asn Lys Lys Gln Ile Val Phe Lys Glu Asn Gln Lys Ala Ser Ser Asn 
625                 630                 635                 640 


Tyr Asp Glu Leu Leu Lys Lys His Gln Phe Thr Pro Lys Asn Lys Arg 
                645                 650                 655     


Pro Ala Leu Arg Lys Tyr Val Phe Tyr Asn Ser Glu Lys Gly Glu Glu 
            660                 665                 670         


Ala Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Lys Gly Phe 
        675                 680                 685             


Lys Thr Lys Trp Lys Gly Tyr Gln His Ser Glu Leu Gln Arg Lys Leu 
    690                 695                 700                 


Ala Phe Tyr Asp Arg His Thr Lys Gln Asp Ile Lys Glu Leu Leu Ser 
705                 710                 715                 720 


Gly Cys Glu Phe Asp His Phe Leu Leu Asp Ile Asn Ala Cys Phe Lys 
                725                 730                 735     


Glu Asp Asp Phe Glu Asp Phe Phe Ser Lys Tyr Leu Lys Asn Arg Ile 
            740                 745                 750         


Glu Thr Leu Asn Ile Ile Leu Lys Gln Leu His Asp Phe Lys Asn Glu 
        755                 760                 765             


Pro Thr Pro Leu Lys Gly Val Phe Lys Asn Cys Leu Lys Phe Leu Lys 
    770                 775                 780                 


Gln Lys Asn Tyr Val Thr Glu Asn Pro Glu Ile Ile Lys Lys Arg Ile 
785                 790                 795                 800 


Leu Ala Lys Pro Ala Phe Leu Pro Arg Gly Ile Phe Asp Glu Arg Pro 
                805                 810                 815     


Thr Met Lys Lys Gly Lys Asn Pro Leu Ile Asp Arg Asp Glu Phe Ala 
            820                 825                 830         


Lys Trp Phe Val Glu Tyr Leu Glu Asn Lys Asp Tyr Gln Lys Phe Tyr 
        835                 840                 845             


Asn Ser Glu Glu Tyr Arg Ile Arg Asp Ala Asp Phe Lys Lys Asn Ala 
    850                 855                 860                 


Val Ile Lys Lys Gln Lys Leu Lys Asp Phe Tyr Thr Leu Gln Met Val 
865                 870                 875                 880 


Asn Tyr Leu Leu Lys Glu Val Phe Gly Lys Asp Glu Met Asn Leu Gln 
                885                 890                 895     


Leu Ser Glu Leu Phe Gln Thr Arg Gln Glu Arg Leu Lys Leu Gln Gly 
            900                 905                 910         


Ile Ala Lys Lys Gln Met Asn Lys Glu Thr Gly Asp Ser Ser Glu Asn 
        915                 920                 925             


Thr Arg Asn Gln Thr Tyr Ile Trp Asn Lys Asp Val Pro Val Ser Phe 
    930                 935                 940                 


Phe Asn Gly Lys Val Thr Ile Asp Lys Val Lys Leu Lys Asn Ile Gly 
945                 950                 955                 960 


Lys Tyr Lys Arg Tyr Glu Arg Asp Glu Arg Val Lys Thr Phe Ile Gly 
                965                 970                 975     


Tyr Glu Val Asp Glu Lys Trp Met Met Tyr Leu Pro His Asn Trp Lys 
            980                 985                 990         


Asp Arg Tyr Ser Val Lys Pro Ile  Asn Val Ile Asp Leu  Gln Ile Gln 
        995                 1000                 1005             


Glu Tyr  Glu Glu Ile Arg Ser  His Glu Leu Leu Lys  Glu Ile Gln 
    1010                 1015                 1020             


Asn Leu  Glu Gln Tyr Ile Tyr  Asp His Thr Thr Asp  Lys Asn Thr 
    1025                 1030                 1035             


Leu Leu  Gln Asp Gly Asn Pro  Asn Phe Lys Met Tyr  Val Leu Asn 
    1040                 1045                 1050             


Gly Leu  Leu Thr Gly Ile Lys  Gln Val Asn Ile Ala  Asp Phe Ile 
    1055                 1060                 1065             


Val Leu  Lys Gln Asn Thr Asn  Phe Asp Lys Ile Asp  Phe Thr Gly 
    1070                 1075                 1080             


Ile Ala  Ser Cys Ser Glu Leu  Glu Lys Lys Thr Ile  Ile Leu Ile 
    1085                 1090                 1095             


Ala Ile  Arg Asn Lys Phe Ala  His Asn Gln Leu Pro  Asn Lys Thr 
    1100                 1105                 1110             


Ile Tyr  Asp Leu Ala Asn Glu  Phe Leu Lys Lys Glu  Lys Arg Glu 
    1115                 1120                 1125             


Thr Tyr  Ala Asn Tyr Tyr Leu  Lys Val Leu Lys Lys  Met Ile Ser 
    1130                 1135                 1140             


Asp Leu  Ala 
    1145     


<210>  2361
<211>  948
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2361

Leu Phe Phe Ser Phe His Asn Ala Gln Arg Val Ile Phe Lys His Leu 
1               5                   10                  15      


Tyr Lys Ala Phe Asp Ala Ser Leu Arg Met Val Lys Glu Asp Tyr Lys 
            20                  25                  30          


Ala His Phe Thr Val Asn Leu Thr Arg Asp Phe Ala His Leu Asn Arg 
        35                  40                  45              


Lys Gly Lys Asn Lys Gln Asp Asn Pro Asp Phe Asn Arg Tyr Arg Phe 
    50                  55                  60                  


Glu Lys Asp Gly Phe Phe Thr Glu Ser Gly Leu Leu Phe Phe Thr Asn 
65                  70                  75                  80  


Leu Phe Leu Asp Lys Arg Asp Ala Tyr Trp Met Leu Lys Lys Val Ser 
                85                  90                  95      


Gly Phe Lys Ala Ser His Lys Gln Arg Glu Lys Met Thr Thr Glu Val 
            100                 105                 110         


Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu Glu Ser Arg 
        115                 120                 125             


Tyr Asp His Asn Gln Met Leu Leu Asp Met Leu Ser Glu Leu Ser Arg 
    130                 135                 140                 


Cys Pro Lys Leu Leu Tyr Glu Lys Leu Ser Glu Glu Asn Lys Lys His 
145                 150                 155                 160 


Phe Gln Val Glu Ala Asp Gly Phe Leu Asp Glu Ile Glu Glu Glu Gln 
                165                 170                 175     


Asn Pro Phe Lys Asp Thr Leu Ile Arg His Gln Asp Arg Phe Pro Tyr 
            180                 185                 190         


Phe Ala Leu Arg Tyr Leu Asp Leu Asn Glu Ser Phe Lys Ser Ile Arg 
        195                 200                 205             


Phe Gln Val Asp Leu Gly Thr Tyr His Tyr Cys Ile Tyr Asp Lys Lys 
    210                 215                 220                 


Ile Gly Asp Glu Gln Glu Lys Arg His Leu Thr Arg Thr Leu Leu Ser 
225                 230                 235                 240 


Phe Gly Arg Leu Gln Asp Phe Thr Glu Ile Asn Arg Pro Gln Glu Trp 
                245                 250                 255     


Lys Ala Leu Thr Lys Asp Leu Asp Tyr Lys Glu Thr Ser Asn Gln Pro 
            260                 265                 270         


Phe Ile Ser Lys Thr Thr Pro His Tyr His Ile Thr Asp Asn Lys Ile 
        275                 280                 285             


Gly Phe Arg Leu Gly Thr Ser Lys Glu Leu Tyr Pro Ser Leu Glu Ile 
    290                 295                 300                 


Lys Asp Gly Ala Asn Arg Ile Ala Lys Tyr Pro Tyr Asn Ser Gly Phe 
305                 310                 315                 320 


Val Ala His Ala Phe Ile Ser Val His Glu Leu Leu Pro Leu Met Phe 
                325                 330                 335     


Tyr Gln His Leu Thr Gly Lys Ser Glu Asp Leu Leu Lys Glu Thr Val 
            340                 345                 350         


Arg His Ile Gln Arg Ile Tyr Lys Asp Phe Glu Glu Glu Arg Ile Asn 
        355                 360                 365             


Thr Ile Glu Asp Leu Glu Lys Ala Asn Gln Gly Arg Leu Pro Leu Gly 
    370                 375                 380                 


Ala Phe Pro Lys Gln Met Leu Gly Leu Leu Gln Asn Lys Gln Pro Asp 
385                 390                 395                 400 


Leu Ser Glu Lys Ala Lys Ile Lys Ile Glu Lys Leu Ile Ala Glu Thr 
                405                 410                 415     


Lys Leu Leu Ser His Arg Leu Asn Thr Lys Leu Lys Ser Ser Pro Lys 
            420                 425                 430         


Leu Gly Lys Arg Arg Glu Lys Leu Ile Lys Thr Gly Val Leu Ala Asp 
        435                 440                 445             


Trp Leu Val Lys Asp Phe Met Arg Phe Gln Pro Val Ala Tyr Asp Ala 
    450                 455                 460                 


Gln Asn Gln Pro Ile Lys Ser Ser Lys Ala Asn Ser Thr Glu Phe Trp 
465                 470                 475                 480 


Phe Ile Arg Arg Ala Leu Ala Leu Tyr Gly Gly Glu Lys Asn Arg Leu 
                485                 490                 495     


Glu Gly Tyr Phe Lys Gln Thr Asn Leu Ile Gly Asn Thr Asn Pro His 
            500                 505                 510         


Pro Phe Leu Asn Lys Phe Asn Trp Lys Ala Cys Arg Asn Leu Val Asp 
        515                 520                 525             


Phe Tyr Gln Gln Tyr Leu Glu Gln Arg Glu Lys Phe Leu Glu Ala Ile 
    530                 535                 540                 


Lys Asn Gln Pro Trp Glu Pro Tyr Gln Tyr Cys Leu Leu Leu Lys Ile 
545                 550                 555                 560 


Pro Lys Glu Asn Arg Lys Asn Leu Val Lys Gly Trp Glu Gln Gly Gly 
                565                 570                 575     


Ile Ser Leu Pro Arg Gly Leu Phe Thr Glu Ala Ile Arg Glu Thr Leu 
            580                 585                 590         


Ser Glu Asp Leu Met Leu Ser Lys Pro Ile Arg Lys Glu Ile Lys Lys 
        595                 600                 605             


His Gly Arg Val Gly Phe Ile Ser Arg Ala Ile Thr Leu Tyr Phe Lys 
    610                 615                 620                 


Glu Lys Tyr Gln Asp Lys His Gln Ser Phe Tyr Asn Leu Ser Tyr Lys 
625                 630                 635                 640 


Leu Glu Ala Lys Ala Pro Leu Leu Lys Arg Glu Glu His Tyr Glu Tyr 
                645                 650                 655     


Trp Gln Gln Asn Lys Pro Gln Ser Pro Thr Glu Ser Gln Arg Leu Glu 
            660                 665                 670         


Leu His Thr Ser Asp Arg Trp Lys Asp Tyr Leu Leu Tyr Lys Arg Trp 
        675                 680                 685             


Gln His Leu Glu Lys Lys Leu Arg Leu Tyr Arg Asn Gln Asp Val Met 
    690                 695                 700                 


Leu Trp Leu Met Thr Leu Glu Leu Thr Lys Asn His Phe Lys Glu Leu 
705                 710                 715                 720 


Asn Leu Asn Tyr His Gln Leu Lys Leu Glu Asn Leu Ala Val Asn Val 
                725                 730                 735     


Gln Glu Ala Asp Ala Lys Leu Asn Pro Leu Asn Gln Thr Leu Pro Met 
            740                 745                 750         


Val Leu Pro Val Lys Val Tyr Pro Ala Thr Ala Phe Gly Glu Val Gln 
        755                 760                 765             


Tyr His Lys Thr Pro Ile Arg Thr Val Tyr Ile Arg Glu Glu His Thr 
    770                 775                 780                 


Lys Ala Leu Lys Met Gly Asn Phe Lys Ala Leu Val Lys Asp Arg Arg 
785                 790                 795                 800 


Leu Asn Gly Leu Phe Ser Phe Ile Lys Glu Glu Asn Asp Thr Gln Lys 
                805                 810                 815     


His Pro Ile Ser Gln Leu Arg Leu Arg Arg Glu Leu Glu Ile Tyr Gln 
            820                 825                 830         


Ser Leu Arg Val Asp Ala Phe Lys Glu Thr Leu Ser Leu Glu Glu Lys 
        835                 840                 845             


Leu Leu Asn Lys His Thr Ser Leu Ser Ser Leu Glu Asn Glu Phe Arg 
    850                 855                 860                 


Ala Leu Leu Glu Glu Trp Lys Lys Glu Tyr Ala Ala Ser Ser Met Val 
865                 870                 875                 880 


Thr Asp Glu His Ile Ala Phe Ile Ala Ser Val Arg Asn Ala Phe Cys 
                885                 890                 895     


His Asn Gln Tyr Pro Phe Tyr Lys Glu Ala Leu His Ala Pro Ile Pro 
            900                 905                 910         


Leu Phe Thr Val Ala Gln Pro Thr Thr Glu Glu Lys Asp Gly Leu Gly 
        915                 920                 925             


Ile Ala Glu Ala Leu Leu Lys Val Leu Arg Glu Tyr Cys Glu Ile Val 
    930                 935                 940                 


Lys Ser Gln Ile 
945             


<210>  2362
<211>  1272
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2362

Met Gly Lys Asn Asn His Tyr Gly Lys Lys Pro Asn Asp Ser Val Lys 
1               5                   10                  15      


Pro Gln Gln Lys Ala Asn Gln Asn Asn Gly Ser Asn Gln Gln Val Asn 
            20                  25                  30          


Asn Ala Pro Ser Tyr Pro Ser Leu Leu Glu Ala Pro Lys Leu Ile Ser 
        35                  40                  45              


Thr Ser Asn Asn Leu Arg Pro Ile Tyr Ala Ala Tyr Leu Asn Met Ala 
    50                  55                  60                  


Arg Gln Asn Leu Tyr Asn Val Leu Gln His Val Ser Val Leu Val Gly 
65                  70                  75                  80  


Tyr Asp Asn Lys Cys Asp Glu Glu Ala Met Lys Gln Met Lys Val Ile 
                85                  90                  95      


Asn Phe Ala Lys Glu Lys Ser Glu Lys Arg Ile Arg Ile Gln Lys Glu 
            100                 105                 110         


Leu Leu Tyr Ala Ile Pro Val Leu Arg Gln Met Leu Ser Val Asp Val 
        115                 120                 125             


Asp Glu Glu Lys Lys Thr Ile Thr Asp Glu Asp Val Gln Ser Leu Leu 
    130                 135                 140                 


Lys Asn Ile Val Ser Thr Ile Phe Asp Leu Arg Asn Phe Tyr Thr His 
145                 150                 155                 160 


Tyr Lys Pro Tyr Asn Ser Pro Glu Glu Ile Ser Phe Gln Lys Glu Thr 
                165                 170                 175     


Glu Arg Ala Leu Phe Pro Tyr Ile Asp Lys Ala Phe Asp Ser Ala Lys 
            180                 185                 190         


Arg Lys Val Glu Ala Ile Trp Asp Tyr Asn Lys Lys Asp Leu Arg Phe 
        195                 200                 205             


Tyr Glu Gly Ser Glu Arg Met Thr Val Thr Arg Lys Gly Lys Lys Lys 
    210                 215                 220                 


Ala Gln Lys Arg Val Lys Phe Phe Phe Asn Pro Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Ser Ala Leu Ser Ala Val Gly Ile Ala Phe Leu Ile Cys Lys Leu Leu 
                245                 250                 255     


Pro Lys Gln Tyr Ser Thr Gln Phe Leu Gln Gln Ile Lys Leu Phe Glu 
            260                 265                 270         


Arg Ser Pro Tyr Lys Lys Glu His Pro Ile Phe Gly Lys Ala Asn Glu 
        275                 280                 285             


Val Met Tyr Asn Met Phe Cys Ile Asp His Ile Arg Leu Pro Lys Gly 
    290                 295                 300                 


Arg Met Glu Ser Ile Ala Asp Glu Thr Ile Leu Gly Leu Asp Met Ile 
305                 310                 315                 320 


Asn Glu Leu Arg Lys Cys Pro Phe Glu Leu Phe Lys Val Leu Ser Glu 
                325                 330                 335     


Lys Asp Gln Lys Leu Phe Glu Val Glu Ala Lys Glu Asn Glu Pro Gly 
            340                 345                 350         


Glu Lys Glu Pro Ala Val Thr Gln Leu Asn Leu Met Arg Arg Tyr Lys 
        355                 360                 365             


Asp Arg Phe Ser Tyr Leu Ala Leu Arg Tyr Ile Asp Phe Gln Lys Asp 
    370                 375                 380                 


Ile Leu Pro Gly Met Ala Phe Gln Val Ala Leu Gly Thr Tyr Arg Tyr 
385                 390                 395                 400 


His Phe Tyr Asp Lys Lys Asn Cys Ile Asp Gly Gly Glu Pro Arg Val 
                405                 410                 415     


Arg Ile Trp Gln Lys Glu Ile Asn Gly Phe Gly Arg Leu Pro Gln Ile 
            420                 425                 430         


Glu Ala Glu Arg Lys Arg Lys Tyr Gly Lys Lys Glu Asp Gly Ser Lys 
        435                 440                 445             


Gly Val Phe Ile Arg Pro Phe Asp Glu Val Thr Val Asp Thr Ala Glu 
    450                 455                 460                 


Thr Glu Pro Tyr Ile Thr Asp Arg His Ala Gly Tyr Ala Ile Thr Gly 
465                 470                 475                 480 


Asn Arg Ile Gly Ile Met Trp His Asp Asp Lys His Glu Asp Phe Lys 
                485                 490                 495     


Asn Asn Gln Tyr Leu Pro Glu Leu Pro Leu Pro Ser Val Gln Thr Glu 
            500                 505                 510         


Asn Gly Glu Lys Val Gly Ala Lys Val Ser Ile Lys Asn Leu Glu Pro 
        515                 520                 525             


Ile Cys Trp Leu Ser Thr Phe Asp Leu Pro Gly Leu Ile Phe Leu His 
    530                 535                 540                 


Leu Leu Gly Gly Lys Pro Asp Thr Val Ile Lys Ser Lys Tyr Glu Ser 
545                 550                 555                 560 


Leu Lys Lys Leu Leu Asn Tyr Ile Lys Gly Asp Glu Phe Val Asp Leu 
                565                 570                 575     


Tyr Lys Asn Glu Ile Ala Ala His Ile Glu Lys Tyr Asp Ser Ala Gly 
            580                 585                 590         


Leu Ser Lys Glu Glu Glu Thr Leu Leu Arg Lys Arg Leu Lys Ala Gln 
        595                 600                 605             


Leu Glu Pro Ile Val Phe Ser Lys Phe Asn Leu His Val Asn Asp Leu 
    610                 615                 620                 


Pro Glu Met Ile Thr Asp Ile Leu Ile Gly Lys Thr Gly His Asp Glu 
625                 630                 635                 640 


Gln Thr Glu Lys Asp His Ala Glu Lys Arg Phe Asn Glu Trp Ala Arg 
                645                 650                 655     


Asn Lys Val Glu Lys Met Ile Glu Ser Leu Glu Arg Arg Ile Lys Gly 
            660                 665                 670         


Phe Glu Lys Asp Leu Glu Lys Val Gly Thr Lys Ala Asn Arg Val Gly 
        675                 680                 685             


Lys Asp Asn Phe Val Asp Ile Arg Pro Gly Ser Leu Ala Arg Tyr Leu 
    690                 695                 700                 


Ala Lys Asp Ile Met Gly Phe Gln Pro Thr Ile Ala Asp Glu Asp Lys 
705                 710                 715                 720 


Arg Gly Thr Asp Lys Leu Thr Gly Leu Asn Phe Gln Ile Met Gln Ser 
                725                 730                 735     


Ala Ile Ala Thr Phe Glu Gly Asn Ser Leu Gln Gly Thr Gln Thr Pro 
            740                 745                 750         


Leu Trp Gln Leu Phe Lys Arg Ala Asn Leu Leu Ala Lys Asp Val Asn 
        755                 760                 765             


Gly Asp Lys Asn Pro Gln Lys His Pro Phe Leu Asn Asp Val Met Ser 
    770                 775                 780                 


Ser Thr Leu Lys Asp Thr Val Asp Leu Tyr Arg Arg Tyr Gln Glu His 
785                 790                 795                 800 


Lys Leu Lys Tyr Leu Arg Lys Ile Leu Glu Glu Asn Asn Phe Lys Glu 
                805                 810                 815     


Ala Tyr Phe Leu His Gly Asn Arg Lys Arg Tyr Ala Pro Lys Thr Leu 
            820                 825                 830         


Glu Ala Val Arg Ser Leu Ala Glu Arg Tyr Leu Asn Thr Leu Tyr Leu 
        835                 840                 845             


Pro Asp Gly Leu Phe Ala Glu Glu Ile Asn Lys Val Leu Lys Asp Lys 
    850                 855                 860                 


Tyr Lys Asp Asn Lys Ser Ile Gln Glu Ala Phe Gln Asp Pro Lys Gln 
865                 870                 875                 880 


Lys Tyr Asn Ile Ala Tyr Leu Leu Asn Val Tyr Phe Glu Gln Val His 
                885                 890                 895     


Lys Asp Cys Cys Gln Pro Phe Tyr Tyr Ser Arg Asn Gly Met Phe Lys 
            900                 905                 910         


Arg Asn Tyr Glu Leu Phe Asn Thr Leu Ala Ser Ser Lys Asn Asn Lys 
        915                 920                 925             


Val Val Lys Trp Tyr Thr Val Asp Glu Met Asn Asp Leu Thr Lys Lys 
    930                 935                 940                 


Gly Ser Gln Asp Met Ser Ile Ala Lys Arg Lys Ile Glu Glu Tyr Leu 
945                 950                 955                 960 


Asp Asn Tyr Met Val Lys Asp Glu Ile Asp Asp Thr Glu Arg Leu Ala 
                965                 970                 975     


Thr Glu Glu Glu Lys Thr Arg Lys Arg Arg Phe Leu Ile Ser Leu Leu 
            980                 985                 990         


Asn Asp Cys Lys Lys Asn Glu Lys  Ile Ile Arg Arg Tyr  Lys Thr Glu 
        995                 1000                 1005             


Asp Ile  Leu Leu Phe Leu Met  Ala Lys Lys Ile Leu  Val Gly Lys 
    1010                 1015                 1020             


Leu Lys  Thr Gln Lys Gly Arg  Thr Ile Glu Gln Ser  Glu Phe Asn 
    1025                 1030                 1035             


Glu Phe  Lys Leu Ser Ala Ile  Pro Ala Phe Lys Arg  Ala Gln Lys 
    1040                 1045                 1050             


Gln Gly  Glu Glu Glu Lys Glu  Tyr Lys Glu Leu Asn  Asp Asn Arg 
    1055                 1060                 1065             


Asp Ile  Leu Ser Lys Phe Ile  Asp Phe Asn Val Glu  Ile Val Leu 
    1070                 1075                 1080             


Arg Asp  Glu Lys Gly Arg Glu  Ile Leu Asp Asp Lys  Gly Thr Pro 
    1085                 1090                 1095             


Ile Arg  Lys Lys Val Tyr Gln  Glu His Leu Gln Leu  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Asp  Phe Tyr Arg Phe Leu  Tyr Asp Thr Arg Ile  Gly Leu Leu 
    1115                 1120                 1125             


Leu Lys  Gln Leu Thr Ser Glu  Cys Ile Lys Arg Glu  Asp Ile Asp 
    1130                 1135                 1140             


Asp Glu  Leu Asp Glu Tyr Asp  Arg Asn Arg Lys Glu  Ile Phe Ala 
    1145                 1150                 1155             


Lys Ile  His Ala Ile Glu Lys  Leu Ile Ile Asn Ala  His Ala Asp 
    1160                 1165                 1170             


Gln Leu  Asp Asp Ser Asn Ala  Gly Lys Glu Gly Phe  Val Asn Glu 
    1175                 1180                 1185             


Asp Gly  Glu Pro Tyr Arg Thr  Asn Phe Arg Ser Leu  Leu Ser Leu 
    1190                 1195                 1200             


Val Glu  Ser Ile Arg Ile Asp  Arg Lys Lys Leu Thr  Lys Glu Gly 
    1205                 1210                 1215             


Glu Leu  Ile Val Glu Thr Arg  Asn Ala Phe Ser His  Asn Lys Tyr 
    1220                 1225                 1230             


Ile Glu  Gln Leu Lys Asp Ile  Ala Asp Glu Lys Gly  Leu Thr Leu 
    1235                 1240                 1245             


Pro Glu  Val Ala Lys Leu Ile  Leu Ala Asn Leu Asn  Arg Phe Ala 
    1250                 1255                 1260             


Ile Lys  Leu Gly Ile Ala Thr  Lys Lys 
    1265                 1270         


<210>  2363
<211>  1403
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2363

Met Gly Lys Asn Lys Gln Lys Lys Lys Ile Gln Ser Gln Asp Ser Ser 
1               5                   10                  15      


Lys Ala Asn Asn Pro Tyr Pro Ser Val Thr Lys Pro Gln Arg Pro Asp 
            20                  25                  30          


Phe Cys Leu Glu Gly Phe Tyr Thr Gln Gln Ala Phe Val Asp Val Arg 
        35                  40                  45              


His Val Ala Ala Asn Tyr Phe Asn Leu Ala His Asn Asn Phe Tyr Lys 
    50                  55                  60                  


Thr Leu Ile Tyr Val Leu Thr Arg Ser Gly Ile Asp Leu Lys Thr Leu 
65                  70                  75                  80  


Asn Phe Trp Asn Phe Lys Asp Asp Ser Ile Gly Thr Val Leu Gln Thr 
                85                  90                  95      


Val Cys Asp Ala Thr Phe Gly Ser Gly Glu Gln Lys Gln Ala Ile Lys 
            100                 105                 110         


Asp Tyr Tyr Phe Ser Ile Glu Glu Lys Lys Leu Ile Val Glu Asn Asn 
        115                 120                 125             


Lys Glu Asn Asp Ser Asn Lys Lys Lys Ser Asp Ala Glu Ile Arg Glu 
    130                 135                 140                 


Leu Ser Leu Gln Arg Ala Glu Lys Asp Phe Gly Ser Phe Val Leu Phe 
145                 150                 155                 160 


Glu Asp Met Gln Gly Arg Ile Gln Lys Lys Leu Phe His His Ile Pro 
                165                 170                 175     


Ala Phe Gly Pro Ile Met Ala Asp Val Ala Ser Tyr Glu Ala Tyr Lys 
            180                 185                 190         


Asn Arg Gln Lys Ser Asp Glu Leu Lys Asp Lys Asn Lys Glu Lys Ile 
        195                 200                 205             


Leu Arg Gly Ile Thr Phe Gln Gln Cys Leu Glu Thr Leu Ile Ile Ile 
    210                 215                 220                 


Ala Asn Ala Leu Asn Tyr Tyr Arg Asn Phe Tyr Thr His Glu Ile Pro 
225                 230                 235                 240 


Tyr Asn Glu Leu Glu Glu Glu Trp Ser Gln Thr Leu Arg Glu Ala Lys 
                245                 250                 255     


Leu Val Lys Tyr Met Asn Asn Val Phe Lys Ala Ser Gln Arg Leu Asp 
            260                 265                 270         


Lys Lys Arg Glu Leu Val Thr Thr Glu Ala Met Thr Phe Leu Thr Gly 
        275                 280                 285             


His Gly Ser Gly Asp Pro Cys Asp Arg Met Lys Glu Ile Pro Asn Gly 
    290                 295                 300                 


Glu Lys Thr Tyr Phe Asp Glu Lys Lys His Arg Asn Val Thr Ile Lys 
305                 310                 315                 320 


Val Tyr Arg Tyr Glu Glu Asn Glu Asn Phe Phe Phe Lys Ile Ala Gly 
                325                 330                 335     


Arg Glu Phe Thr Thr Glu Asp Gly Gly Lys Ala Asn Tyr Leu Ser Asp 
            340                 345                 350         


Phe Gly Lys Leu Leu Phe Cys Cys Leu Phe Leu Lys Arg Gln Gln Thr 
        355                 360                 365             


Gln Asn Phe Ala Ile Glu Ser Arg Leu Leu Glu Phe Ser Pro Tyr Leu 
    370                 375                 380                 


Leu Lys Pro His Glu Leu Gln Lys Lys Gln Ala Glu Glu Asn Lys Arg 
385                 390                 395                 400 


Val Asp Lys Glu Asn Lys Leu Arg Gln Ala Gln Gly Lys Lys Arg Met 
                405                 410                 415     


Leu Thr Pro Lys Gln Phe Thr Lys His Asp Ser Leu Gln Asn Glu Ile 
            420                 425                 430         


Ile Leu Asp Met Leu Gly Ile Tyr His Ile Arg Arg Pro Leu Glu Lys 
        435                 440                 445             


Arg Ile Asp Ala Lys Ala Thr Pro Gly Thr Leu Ala Met Asp Met Leu 
    450                 455                 460                 


Asn Glu Leu Arg Arg Cys Pro Ser Glu Leu Tyr Gln Thr Phe Ser Ala 
465                 470                 475                 480 


Asp Asp Lys Asp Ile Phe Glu Arg Glu Val Ser Asp Pro Lys Asp Gly 
                485                 490                 495     


Ser Pro Arg Ser Ala Lys Ala Glu Glu Lys Val Lys Leu Ile Arg Tyr 
            500                 505                 510         


Thr Asp Arg Phe Pro Tyr Leu Ala Leu Arg Tyr Ile Asp Glu Thr Asn 
        515                 520                 525             


Leu Ile Gly Asp Ile Arg Phe His Ile Arg Leu Gly Asn Tyr Arg Phe 
    530                 535                 540                 


His Phe Tyr Asp Lys Thr Cys Val Asp Gly Asn Pro Lys Ile Arg Ser 
545                 550                 555                 560 


Trp Gln Lys Glu Ile Asn Gly Phe Gly Lys Trp Gln Glu Ile Glu Glu 
                565                 570                 575     


Lys Arg Lys Ser Lys Trp Ala Asn Gln Phe Gln Lys Arg Glu Tyr Val 
            580                 585                 590         


Asn Thr Arg Gln Glu Tyr Gly Glu Met Glu Leu Glu Gln Pro Val Lys 
        595                 600                 605             


Asp His Ala Asp Thr Lys Pro Tyr Ile Thr Asp Trp Thr Ala Ala Tyr 
    610                 615                 620                 


Asn Ile His Ala Asn Arg Ile Gly Leu Tyr Trp Gly Leu Glu Asp Gly 
625                 630                 635                 640 


Met Phe Leu Pro Asp Leu Asn Thr Ile Val Asp Pro Thr Asp Ala Asn 
                645                 650                 655     


Ala Ser Gln Glu Glu Leu Arg Lys Ser Glu Met Lys Pro Arg His Arg 
            660                 665                 670         


Ala Pro Val Ile Met Lys Glu Pro Leu Cys Thr Leu Ser Thr Tyr Asp 
        675                 680                 685             


Leu Pro Ala Leu Leu Phe Tyr Asn Tyr Leu Phe Lys His Tyr Asn Ala 
    690                 695                 700                 


Ala Lys Tyr Lys Met Pro Met Pro Asn Lys Ile Ile Lys Asp Ala Tyr 
705                 710                 715                 720 


Asp Gly Leu Lys Ala Phe Ile Asp Ala Ile Ala Ala Arg Lys Lys Gly 
                725                 730                 735     


Lys Asp Leu Glu Glu Val Leu Gln Gln Lys Gly Val Arg Glu Phe Asp 
            740                 745                 750         


Ile Pro Lys Ala Leu Arg Lys Arg Leu Glu Ser Gln Gly Lys Pro Glu 
        755                 760                 765             


Gln Phe Asn Asn Lys Ile Tyr Met Arg Leu Val Glu Arg Val Tyr Gly 
    770                 775                 780                 


Arg Tyr Asp Ile Glu Arg Glu Met Tyr Val Pro Gly Lys Leu Ser Glu 
785                 790                 795                 800 


Lys Leu Glu Glu Ile Glu Tyr Arg Ile Lys Ala Phe Lys Asp Lys Lys 
                805                 810                 815     


Ala Lys Ile Asp Ser Gly Asp Asn Lys Tyr Ala Lys Lys Gly Tyr Ala 
            820                 825                 830         


Asp Ile Arg His Gly Val Leu Ala Arg Tyr Leu Ala Lys Ser Phe Met 
        835                 840                 845             


Gln Trp Gln Pro Thr Lys Asp Lys Gly His Asp Lys Ile Thr Gly Leu 
    850                 855                 860                 


Asn Tyr Ser Val Met Thr Ala Phe Leu Ser Thr Tyr Gly Ile Asn Ser 
865                 870                 875                 880 


Asp Ile Val Gln Leu Arg Thr Leu Leu Glu Lys Ala Lys Leu Ile Gly 
                885                 890                 895     


Ser Ala Asn Pro His Pro Phe Leu Pro Glu Val Leu Ala Glu Ser Pro 
            900                 905                 910         


Gln Asn Ile Glu Asp Leu Tyr Phe Ile Tyr Leu Lys Gln Glu Gln Lys 
        915                 920                 925             


Phe Ala Glu Gly Leu Asn Ser His His Gly Lys Leu Lys Ala Phe Lys 
    930                 935                 940                 


Gly Asn Leu Gln Asp Lys Ile Lys Tyr Ile Asn Glu Asn Lys Ser Ser 
945                 950                 955                 960 


Ile Asp Gln Ile Leu Ala Gln Ile Pro Phe Val His Ala Asp Arg Glu 
                965                 970                 975     


Lys Trp Arg Arg Thr Asp Ser Val Asp Lys Tyr Tyr Thr Asp Tyr Ala 
            980                 985                 990         


Gly Arg Tyr His Thr Ile Met Leu  Pro Asp Ser Leu Phe  Thr Pro Tyr 
        995                 1000                 1005             


Ile Ile  Arg Leu Met Lys Ser  Cys Leu Pro Asn Asp  Lys Thr Leu 
    1010                 1015                 1020             


Met Ser  Arg Ile Lys Ala Cys  Glu Ser Asp Ser Arg  Gln Thr Leu 
    1025                 1030                 1035             


Gly Ala  Ala Trp Leu Ile Glu  Tyr Tyr Phe Glu His  His Met Lys 
    1040                 1045                 1050             


Asp Lys  His Gln Gln Phe Tyr  Asn Ala Asn Ile Phe  Arg Arg Ala 
    1055                 1060                 1065             


Tyr Lys  Pro Phe Thr Thr Met  Asn Asn Asp Phe Val  Lys Asn Gln 
    1070                 1075                 1080             


Asn Gly  Gly Asn Thr Asn Glu  Pro Leu Pro Tyr Tyr  Asn Ser Lys 
    1085                 1090                 1095             


Lys Glu  Ile Glu Glu Lys Leu  Ser Tyr Thr Glu Glu  Asp Ile Arg 
    1100                 1105                 1110             


Asn Phe  Val Tyr Asn Val Trp  Arg Gly Lys Thr Lys  Arg Glu Glu 
    1115                 1120                 1125             


Ile Glu  Ile Leu Lys Asn Gln  Ile Lys Asp Val Lys  Asp Thr Glu 
    1130                 1135                 1140             


Lys Val  Ile Arg Arg Tyr Arg  Thr Gln Asp Val Thr  Leu Phe Leu 
    1145                 1150                 1155             


Ala Ala  Lys Asp Leu Leu Thr  Thr Gln Leu Ser Lys  Asp Asp Asn 
    1160                 1165                 1170             


Met Ala  Asp Ala Thr Lys Gln  Ala Met Lys Asn Leu  Lys Glu Lys 
    1175                 1180                 1185             


Ala Glu  Cys Leu Lys Leu Lys  Asp Phe Asp Tyr Asp  Glu Gly Phe 
    1190                 1195                 1200             


Ser Phe  Leu Ser Asp Gly Asp  Asn Pro Glu Ser Gly  Ile Val Tyr 
    1205                 1210                 1215             


Thr Tyr  Glu Tyr Lys Thr Lys  Thr Gly Arg Thr Val  Lys Ile Thr 
    1220                 1225                 1230             


Gln Lys  Gly Val Ser Leu Lys  Asn Tyr Gly Asn Ile  Tyr Arg Ile 
    1235                 1240                 1245             


Leu Gly  Asp Asp Arg Phe Lys  Ser Leu Met Glu Gly  Ile Ala Asn 
    1250                 1255                 1260             


Ile Ala  Thr Thr Asp Ser Ile  Glu Val Thr Phe Asn  Asp Leu Thr 
    1265                 1270                 1275             


Thr Glu  Phe Ala Asn Tyr Asp  Glu Arg Arg Ser Ala  Met Phe Lys 
    1280                 1285                 1290             


Met Val  His Glu Leu Glu Gly  Lys Ala Phe Ile Arg  Asn Glu Lys 
    1295                 1300                 1305             


Glu Leu  Gln Asp Pro Asn Asn  Pro Val Phe His Ile  Lys Asn Asp 
    1310                 1315                 1320             


Leu Ala  Lys Asp Pro Arg Arg  Asn Asn Phe Ser Ser  Leu Leu Glu 
    1325                 1330                 1335             


Leu Leu  Gln Glu Tyr Ser Asp  Lys Asp Gln Lys Val  Met Val Ala 
    1340                 1345                 1350             


Ile Arg  Asn Ala Ile Gly His  Asp Tyr Tyr Met Asp  Ile Thr Leu 
    1355                 1360                 1365             


Leu Asp  Arg Thr Asn Ser Lys  Ala Lys Arg Val Pro  Asn Ile Ser 
    1370                 1375                 1380             


Leu Leu  Met Glu His Thr Leu  Asn Lys Lys Lys Asp  Asn Pro Ser 
    1385                 1390                 1395             


Gln Asp  Lys Lys Lys 
    1400             


<210>  2364
<211>  1145
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2364

Met Thr Leu Pro Thr Asp Asn Thr Phe Ile Glu Lys Ala Asp Gln Glu 
1               5                   10                  15      


Ile Leu Gly Lys Asn Lys Leu Phe Phe Gly Ala Tyr Leu Asn Met Ala 
            20                  25                  30          


Asn His Asn Ala Tyr Leu Ile Ile Lys Asp Ile Ser Glu Arg Leu Lys 
        35                  40                  45              


Gln Glu Asp Ala Leu Asp Ile Asp Ala Pro Ser Asp Glu Asp Asn Leu 
    50                  55                  60                  


Ala Tyr Ala Glu Ile Phe Ser Lys Ile Leu Lys Lys Ala Ser Asp Lys 
65                  70                  75                  80  


Asn Pro Lys Asn Arg Pro Gln Ala Thr Ile Ile Asp Lys Val Thr Asn 
                85                  90                  95      


Leu Leu Ile His His Phe Pro Ala Phe Glu Val Phe Ala Tyr Glu His 
            100                 105                 110         


Pro Phe Glu Gln Gln Asn Ser Tyr Pro Glu Leu Leu Tyr Gln Lys Leu 
        115                 120                 125             


Ser Thr Ala Ser Lys Leu Leu Asn Asp Leu Arg Asn Glu His Ser His 
    130                 135                 140                 


Phe Tyr Tyr Lys Gly Ser Phe Asp Ile Asp Thr Val Phe Ser Ala Ala 
145                 150                 155                 160 


Gln Glu Glu Ile Thr Arg Phe Pro Tyr Leu Thr Pro Glu Asp Ile Glu 
                165                 170                 175     


Glu Leu Glu Tyr Tyr Lys Asn Asp Leu Leu Glu Pro Leu Thr Tyr Phe 
            180                 185                 190         


Lys Lys Tyr Gly Phe Val Phe Phe Ile Cys Thr Phe Leu Glu Lys Arg 
        195                 200                 205             


Tyr Ala Arg Tyr Met Leu Lys Glu Lys Gln Leu Asp Leu Ile Ala Ser 
    210                 215                 220                 


Asp Lys Glu Arg Asp Ala Thr Leu Glu Asn Phe Thr Asn Tyr Ser Cys 
225                 230                 235                 240 


Arg Leu Pro Arg Pro Lys Leu Glu Ser Ser Val Ile Glu Leu Asp Met 
                245                 250                 255     


Leu Asn Glu Leu Ser Arg Cys Pro Lys Gly Ile His Asp Val Leu Ser 
            260                 265                 270         


Ser Pro Met Glu Lys Val Leu Leu Lys Thr Asp Ala Lys Asp Asp Pro 
        275                 280                 285             


Asn Gln Val Pro Met Ile Arg His Asn Asp Arg Phe Pro Tyr Phe Ala 
    290                 295                 300                 


Leu Ser Tyr Phe Asp Lys Met Glu Arg Phe Pro Ala Met Arg Phe His 
305                 310                 315                 320 


Ile Trp Ala Gly Lys Thr Arg Leu Ala Phe Tyr Gly Lys Lys Leu Gly 
                325                 330                 335     


Lys Lys Asn Val Leu Arg Asp Ile Gln Glu Asn Val Thr Ile Tyr Ala 
            340                 345                 350         


Arg Leu Asn Asp Ile Lys Ala Asp Lys Ile Pro Asp Asn Trp Lys Asp 
        355                 360                 365             


Lys Ile Asp Val Glu Asp Ser Glu Glu Asn Lys Glu Lys Ala Lys Ile 
    370                 375                 380                 


Gln Ser Tyr Ser Pro His Tyr Asn Ile His Asn Asn Arg Ile Ala Ile 
385                 390                 395                 400 


Lys Phe Ile Asp Thr Gln Lys Asp Glu Leu Asp Thr Glu Asn Phe Ser 
                405                 410                 415     


Glu Ile Lys Ser Lys Pro Gln Asp Pro Thr Lys Asp Lys Gln Leu Lys 
            420                 425                 430         


Tyr Thr Val Thr His Ala Leu Pro Asn Ala Ile Leu Ser Thr Tyr Glu 
        435                 440                 445             


Leu Gln Asn Leu Phe Leu Tyr Asp Tyr Leu Tyr Arg Thr Tyr Lys Asp 
    450                 455                 460                 


Gln Lys Val Leu Ala Arg Pro Ala Asp Ser Phe Ile Arg Asn Tyr Ile 
465                 470                 475                 480 


Ser Ser Phe His Arg Phe Cys Lys Asp Val Lys Ser Gly Lys Ile Gln 
                485                 490                 495     


Pro Val Ser Pro His Asp Phe Glu Arg Leu Thr Glu His Thr Arg Ser 
            500                 505                 510         


Thr Thr Arg Asp Leu Gly Asn Arg Glu Glu Glu Leu Glu Ile Arg Lys 
        515                 520                 525             


Glu Ala Leu Gln Lys Lys Lys Leu Asp Asn Tyr Gly Leu Lys Val Lys 
    530                 535                 540                 


Asn Leu Pro Asp Ala Leu Arg Glu Tyr Leu Leu Gly Tyr Lys Gln Glu 
545                 550                 555                 560 


Thr Tyr Thr Glu Ile Ala Leu Asn Lys Leu Arg Gly Lys Ile Gln Gln 
                565                 570                 575     


Thr Lys Val His Tyr Lys Leu Ala Thr Lys Asp Asp Leu Phe Leu Asp 
            580                 585                 590         


Gly Lys Thr Asp Leu Lys Ser Gly Lys Ile Gly Asp Phe Leu Ala Ala 
        595                 600                 605             


Asp Ile Val Phe Leu Lys Pro Leu Asp Ala Asn Arg Thr Gly Lys Pro 
    610                 615                 620                 


Asn Asn Gln Gln Phe Asn Glu Leu Gln Lys Ala Ile Ala Arg Phe His 
625                 630                 635                 640 


Ser Gln Lys Lys Asp Val Glu Asp Phe Ile Asn Glu Glu Leu Gln Ile 
                645                 650                 655     


Lys Glu Gln Ser Leu Pro His Ala His Pro Phe Leu Tyr Lys Ile Gln 
            660                 665                 670         


Phe Glu Glu His Thr Asp Val Gln Ser Phe Tyr Ile Lys Tyr Leu Glu 
        675                 680                 685             


Leu Lys Ile Glu Trp Leu Glu Cys Thr Lys Arg Glu Ile Gln Gly Lys 
    690                 695                 700                 


Ser Asp Tyr Leu Lys Pro Trp Gln Trp Arg Glu Glu Ala Asp Lys Cys 
705                 710                 715                 720 


Lys Gln Tyr Gly Ile Asp Ile Lys Pro Glu Gly Leu Ser Asp Ala Ala 
                725                 730                 735     


Thr Glu Asn Lys Tyr Gly Tyr Phe Leu Gln Ile Asn Thr Lys Lys Gly 
            740                 745                 750         


Asn Glu Arg Asn Tyr Thr Asn Ala Thr Thr Arg Ser Lys Ala Asn Ser 
        755                 760                 765             


Lys Glu Phe Glu Ser Leu Glu Ser Lys Ser Pro Val Ile Leu Pro Arg 
    770                 775                 780                 


Gly Leu Phe Asn Asp Ala Ile Ile Asp Ala Met Met Lys Ile Asp Glu 
785                 790                 795                 800 


Phe Lys Gly Lys Ile Lys Glu Gly Asp Asn Ile Val Arg Cys Leu Asp 
                805                 810                 815     


Val Leu Ala Glu Gly Asp Arg Gln Thr Phe Tyr Asp Phe Glu Arg Ser 
            820                 825                 830         


Tyr Thr Val Gly Lys Ala Ala Pro Thr Ser Val Thr Ile His Gln Gly 
        835                 840                 845             


Ala Asn Asp Glu Tyr Ile Lys Asn Lys Leu Arg Ser Ile Lys Pro Ile 
    850                 855                 860                 


Ile Lys Lys Leu Arg Thr Gln Gln Asn Ala Lys Asp Ala Lys Tyr Lys 
865                 870                 875                 880 


Asp Lys Lys Ile Leu Gln Asn His Ile Lys Ala Leu Gln Ala Ile Ser 
                885                 890                 895     


Asp Asn Glu Arg Ser Ile Arg Phe Ile Arg Ala Asn Asp Arg Ala Leu 
            900                 905                 910         


Phe Leu Met Ile Lys His Ile Phe Ser Glu His Lys Ser Tyr Val Val 
        915                 920                 925             


Glu Gly Ser Lys Leu Thr Lys Ser Ile Asn Thr Leu Pro Trp Lys Leu 
    930                 935                 940                 


Asn Lys Val Gly Tyr Glu Ile Lys Glu Asn Asn Ile Leu Asn Glu Ile 
945                 950                 955                 960 


Leu Pro Met Asn Ile Gln Phe Asn Gln Lys Asn Ile Tyr Thr Glu Gly 
                965                 970                 975     


Glu Tyr Gly Thr Asp Pro Leu Asn Lys Leu Ser Ile Lys His Tyr Gly 
            980                 985                 990         


Lys Phe Arg Lys Leu Leu Lys Asp  Lys Arg Leu Ser Asn  Lys Lys Lys 
        995                 1000                 1005             


Pro Gly  Leu Leu Asn Tyr Tyr  Thr Asp Gln Asn Val  Arg Trp Ser 
    1010                 1015                 1020             


Ala Ile  Asn Lys Glu Leu Glu  Tyr Tyr Asp Glu Asn  Arg Asp Arg 
    1025                 1030                 1035             


Leu Leu  Asp Val Ile Tyr Lys  Phe Glu Lys Ala Val  Trp Glu Asn 
    1040                 1045                 1050             


Glu Glu  Cys Arg Glu Glu Leu  Lys Glu Asn Ile Arg  Leu Gly Tyr 
    1055                 1060                 1065             


Ile Asn  His Ala Ala Gln Leu  Lys Ala Val Gly Lys  Ile Val Arg 
    1070                 1075                 1080             


Asp Phe  Thr Ala Ser Lys Gln  Asp Gln Leu Ala Leu  Leu Arg Asn 
    1085                 1090                 1095             


Lys Phe  Leu His Asn Gln Ile  Pro Tyr Thr Glu Asn  Leu Lys Thr 
    1100                 1105                 1110             


Gly Trp  Val Asp Asn Asn Pro  Glu Tyr Pro Leu Ile  Thr Gln Ala 
    1115                 1120                 1125             


Leu Leu  Glu Leu Ala Ile Ile  Glu Tyr Gln Asn Ile  Lys Lys Asn 
    1130                 1135                 1140             


Ile Ile  
    1145 


<210>  2365
<211>  948
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2365

Leu Phe Phe Ser Phe His Asn Ala Gln Arg Val Ile Phe Lys His Leu 
1               5                   10                  15      


Tyr Lys Ala Phe Asp Ala Ser Leu Arg Met Val Lys Glu Asp Tyr Lys 
            20                  25                  30          


Ala His Phe Thr Val Asn Leu Thr Arg Asp Phe Ala His Leu Asn Arg 
        35                  40                  45              


Lys Gly Lys Asn Lys Gln Asp Asn Pro Asp Phe Asn Arg Tyr Arg Phe 
    50                  55                  60                  


Glu Lys Asp Gly Phe Phe Thr Glu Ser Gly Leu Leu Phe Phe Thr Asn 
65                  70                  75                  80  


Leu Phe Leu Asp Lys Arg Asp Ala Tyr Trp Met Leu Lys Lys Val Ser 
                85                  90                  95      


Gly Phe Lys Ala Ser His Lys Gln Arg Glu Lys Met Thr Thr Glu Val 
            100                 105                 110         


Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu Glu Ser Arg 
        115                 120                 125             


Tyr Asp His Asn Gln Met Leu Leu Asp Met Leu Ser Glu Leu Ser Arg 
    130                 135                 140                 


Cys Pro Lys Leu Leu Tyr Glu Lys Leu Ser Glu Glu Asn Lys Lys His 
145                 150                 155                 160 


Phe Gln Val Glu Ala Asp Gly Phe Leu Asp Glu Ile Glu Glu Glu Gln 
                165                 170                 175     


Asn Pro Phe Lys Asp Thr Leu Ile Arg His Gln Asp Arg Phe Pro Tyr 
            180                 185                 190         


Phe Ala Leu Arg Tyr Leu Asp Leu Asn Glu Ser Phe Lys Ser Ile Arg 
        195                 200                 205             


Phe Gln Val Asp Leu Gly Thr Tyr His Tyr Cys Ile Tyr Asp Lys Lys 
    210                 215                 220                 


Ile Gly Asp Glu Gln Glu Lys Arg His Leu Thr Arg Thr Leu Leu Ser 
225                 230                 235                 240 


Phe Gly Arg Leu Gln Asp Phe Thr Glu Ile Asn Arg Pro Gln Glu Trp 
                245                 250                 255     


Lys Ala Leu Thr Lys Asp Leu Asp Tyr Lys Glu Thr Ser Asn Gln Pro 
            260                 265                 270         


Phe Ile Ser Lys Thr Thr Pro His Tyr His Ile Thr Asp Asn Lys Ile 
        275                 280                 285             


Gly Phe Arg Leu Gly Thr Ser Lys Glu Leu Tyr Pro Ser Leu Glu Ile 
    290                 295                 300                 


Lys Asp Gly Ala Asn Arg Ile Ala Lys Tyr Pro Tyr Asn Ser Gly Phe 
305                 310                 315                 320 


Val Ala His Ala Phe Ile Ser Val His Glu Leu Leu Pro Leu Met Phe 
                325                 330                 335     


Tyr Gln His Leu Thr Gly Lys Ser Glu Asp Leu Leu Lys Glu Thr Val 
            340                 345                 350         


Arg His Ile Gln Arg Ile Tyr Lys Asp Phe Glu Glu Glu Arg Ile Asn 
        355                 360                 365             


Thr Ile Glu Asp Leu Glu Lys Ala Asn Gln Gly Arg Leu Pro Leu Gly 
    370                 375                 380                 


Ala Phe Pro Lys Gln Met Leu Gly Leu Leu Gln Asn Lys Gln Pro Asp 
385                 390                 395                 400 


Leu Ser Glu Lys Ala Lys Ile Lys Ile Glu Lys Leu Ile Ala Glu Thr 
                405                 410                 415     


Lys Leu Leu Ser His Arg Leu Asn Thr Lys Leu Lys Ser Ser Pro Lys 
            420                 425                 430         


Leu Gly Lys Arg Arg Glu Lys Leu Ile Lys Thr Gly Val Leu Ala Asp 
        435                 440                 445             


Trp Leu Val Lys Asp Phe Met Arg Phe Gln Pro Val Ala Tyr Asp Ala 
    450                 455                 460                 


Gln Asn Gln Pro Ile Lys Ser Ser Lys Ala Asn Ser Thr Glu Phe Trp 
465                 470                 475                 480 


Phe Ile Arg Arg Ala Leu Ala Leu Tyr Gly Gly Glu Lys Asn Arg Leu 
                485                 490                 495     


Glu Gly Tyr Phe Lys Gln Thr Asn Leu Ile Gly Asn Thr Asn Pro His 
            500                 505                 510         


Pro Phe Leu Asn Lys Phe Asn Trp Lys Ala Cys Arg Asn Leu Val Asp 
        515                 520                 525             


Phe Tyr Gln Gln Tyr Leu Glu Gln Arg Glu Lys Phe Leu Glu Ala Ile 
    530                 535                 540                 


Lys Asn Gln Pro Trp Glu Pro Tyr Gln Tyr Cys Leu Leu Leu Lys Ile 
545                 550                 555                 560 


Pro Lys Glu Asn Arg Lys Asn Leu Val Lys Gly Trp Glu Gln Gly Gly 
                565                 570                 575     


Ile Ser Leu Pro Arg Gly Leu Phe Thr Glu Ala Ile Arg Glu Thr Leu 
            580                 585                 590         


Ser Glu Asp Leu Met Leu Ser Lys Pro Ile Arg Lys Glu Ile Lys Lys 
        595                 600                 605             


His Gly Arg Val Gly Phe Ile Ser Arg Ala Ile Thr Leu Tyr Phe Lys 
    610                 615                 620                 


Glu Lys Tyr Gln Asp Lys His Gln Ser Phe Tyr Asn Leu Ser Tyr Lys 
625                 630                 635                 640 


Leu Glu Ala Lys Ala Pro Leu Leu Lys Arg Glu Glu His Tyr Glu Tyr 
                645                 650                 655     


Trp Gln Gln Asn Lys Pro Gln Ser Pro Thr Glu Ser Gln Arg Leu Glu 
            660                 665                 670         


Leu His Thr Ser Asp Arg Trp Lys Asp Tyr Leu Leu Tyr Lys Arg Trp 
        675                 680                 685             


Gln His Leu Glu Lys Lys Leu Arg Leu Tyr Arg Asn Gln Asp Val Met 
    690                 695                 700                 


Leu Trp Leu Met Thr Leu Glu Leu Thr Lys Asn His Phe Lys Glu Leu 
705                 710                 715                 720 


Asn Leu Asn Tyr His Gln Leu Lys Leu Glu Asn Leu Ala Val Asn Val 
                725                 730                 735     


Gln Glu Ala Asp Ala Lys Leu Asn Pro Leu Asn Gln Thr Leu Pro Met 
            740                 745                 750         


Val Leu Pro Val Lys Val Tyr Pro Ala Thr Ala Phe Gly Glu Val Gln 
        755                 760                 765             


Tyr His Lys Thr Pro Ile Arg Thr Val Tyr Ile Arg Glu Glu His Thr 
    770                 775                 780                 


Lys Ala Leu Lys Met Gly Asn Phe Lys Ala Leu Val Lys Asp Arg Arg 
785                 790                 795                 800 


Leu Asn Gly Leu Phe Ser Phe Ile Lys Glu Glu Asn Asp Thr Gln Lys 
                805                 810                 815     


His Pro Ile Ser Gln Leu Arg Leu Arg Arg Glu Leu Glu Ile Tyr Gln 
            820                 825                 830         


Ser Leu Arg Val Asp Ala Phe Lys Glu Thr Leu Ser Leu Glu Glu Lys 
        835                 840                 845             


Leu Leu Asn Lys His Thr Ser Leu Ser Ser Leu Glu Asn Glu Phe Arg 
    850                 855                 860                 


Ala Leu Leu Glu Glu Trp Lys Lys Glu Tyr Ala Ala Ser Ser Met Val 
865                 870                 875                 880 


Thr Asp Glu His Ile Ala Phe Ile Ala Ser Val Arg Asn Ala Phe Cys 
                885                 890                 895     


His Asn Gln Tyr Pro Phe Tyr Lys Glu Ala Leu His Ala Pro Ile Pro 
            900                 905                 910         


Leu Phe Thr Val Ala Gln Pro Thr Thr Glu Glu Lys Asp Gly Leu Gly 
        915                 920                 925             


Ile Ala Glu Ala Leu Leu Lys Val Leu Arg Glu Tyr Cys Glu Ile Val 
    930                 935                 940                 


Lys Ser Gln Ile 
945             


<210>  2366
<211>  1213
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2366

Met Glu Lys Asn Ser Leu Gln Asp Thr Thr Arg Thr Lys Asp Asp Val 
1               5                   10                  15      


Leu Tyr Phe Gly Ser Tyr Leu Asn Met Gly Arg His Asn Val Tyr Leu 
            20                  25                  30          


Ile Ile Asn His Val Thr Glu Val Phe Lys His Leu Gly Phe Arg Lys 
        35                  40                  45              


Leu Asn Asp Asp Glu Asp Ile Trp Ser Glu Lys Glu Gln Val Asn Glu 
    50                  55                  60                  


Gly Asn Ile Leu Leu Asn Ile Phe Asp Pro Lys Lys Glu Lys Tyr Gln 
65                  70                  75                  80  


Asp Glu Arg Phe Arg Val Phe Asn Tyr Leu Ile Lys Arg His His Leu 
                85                  90                  95      


Pro Phe Leu Arg Ile Phe Thr Asn Gln Val Leu Asn Asp Ser Gly Glu 
            100                 105                 110         


Ile Gln Asn Pro Glu Lys Lys Asp Met Leu Ile Asp Phe Glu Gly Ala 
        115                 120                 125             


His Val Phe Ile Asn Lys Ile Phe Arg Glu Leu Asn Glu Phe Arg Asn 
    130                 135                 140                 


Ser Tyr Thr His Tyr Leu Ser Leu Ser Asn Glu Gly Thr Pro Leu Pro 
145                 150                 155                 160 


Lys Lys Leu Gln Ile Asn Val Glu Leu Ile Lys Asp Leu Lys Thr Leu 
                165                 170                 175     


Phe Tyr Tyr Ala Pro Glu Phe Ser Phe Ile Arg His Asn Val Leu Lys 
            180                 185                 190         


Gln Glu Ser Lys Glu Glu Tyr Glu Thr Lys Val Lys Ala Tyr Tyr Asn 
        195                 200                 205             


Asp Ile Arg Arg Lys Tyr Arg Leu Phe Glu Gly Asp Glu Ser Ala Gly 
    210                 215                 220                 


Lys Leu Thr Asp Gln Gly Leu Phe Phe Phe Val Asn Leu Phe Leu Glu 
225                 230                 235                 240 


Arg Ser Asn Ala Ile Lys Phe Leu Lys Arg Phe Arg Gly Phe Lys Asn 
                245                 250                 255     


Glu Thr Leu Pro Pro Phe Lys Ala Thr Ile Gln Ser Phe Thr Thr Tyr 
            260                 265                 270         


Ala Leu Lys Ile Pro Asp Val Arg Leu Asp Asn Asp Phe Pro Lys Gln 
        275                 280                 285             


Ala Leu Leu Met Glu Ile Leu Thr Glu Leu Asn Arg Cys Pro Lys Glu 
    290                 295                 300                 


Leu Tyr Gln Val Leu Gly Lys Glu Asp Lys Ala Lys Phe Asp Pro Lys 
305                 310                 315                 320 


Leu Glu Gln Ser Ala Ile Asn Asn Ile Leu Glu Asn Val Asn Tyr Asp 
                325                 330                 335     


Glu Leu Ser Asp Glu His Leu Glu Gln Ala Ile Lys Glu Leu Val Val 
            340                 345                 350         


Leu Lys Arg His Asp Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Leu 
        355                 360                 365             


Asp Glu Met Asn Leu Leu Ser Gln Ile Arg Phe Gln Val Tyr Leu Gly 
    370                 375                 380                 


Lys Val Glu Leu Lys Ser Tyr Phe Lys Asp Asp Leu Gly Ile Glu Arg 
385                 390                 395                 400 


Arg Ile Leu Lys Pro Ile Tyr Ala Phe Gly Lys Leu Ser Asp Phe Asp 
                405                 410                 415     


Asn Lys Glu Glu Asp Ile Leu Arg Glu Leu Lys Lys Asn Leu Pro Pro 
            420                 425                 430         


Asp Cys Gln Asp Ile His Trp Asp Gln Tyr Lys Pro His Tyr Asn Ile 
        435                 440                 445             


Ser Gln Asn Asn Ile Pro Phe Tyr Ile Phe Asn Asp Thr Asp Pro Lys 
    450                 455                 460                 


Val Leu Leu Pro Arg Leu Pro Ile Lys Gly Arg Gln Glu Asp Arg Tyr 
465                 470                 475                 480 


Ser Lys Lys Pro Ala Gly Phe Leu Ser Ile His Ser Leu Pro Lys Phe 
                485                 490                 495     


Val Ile Thr Phe Leu Val Pro Pro Leu Asp Arg Asn Gly Glu Lys Lys 
            500                 505                 510         


Ile Ile Glu Phe Val Lys Ser Thr Asn Gly Phe Ile Leu Asn Tyr Glu 
        515                 520                 525             


Asn Ile Glu Asn Leu Gln Asn Lys Ile Gln Tyr Ala Pro Glu Thr Phe 
    530                 535                 540                 


Thr Arg Arg Met Val Lys Asn Arg Thr Leu Leu Asn Lys Glu Lys Lys 
545                 550                 555                 560 


Val Cys Tyr Val Thr Lys Ser Glu Ile Glu Asp Leu Thr Lys Lys Cys 
                565                 570                 575     


Glu Ile Ser Phe Glu Asp Leu Met Lys Leu Ser Arg Glu Glu Leu Ser 
            580                 585                 590         


Lys Lys Tyr Lys Asn Leu Ser Pro Arg Glu Ile Glu Val Phe Ser Gln 
        595                 600                 605             


Tyr Lys Tyr Glu His Met Leu Ala Ser Arg Lys Glu Ile Leu Met Thr 
    610                 615                 620                 


Glu Val Tyr Asn Asn Leu Pro Asp Leu Asn Leu Glu Phe Lys Tyr Leu 
625                 630                 635                 640 


Pro Gly Lys Ile Arg Asp Lys Leu Leu Lys Ile Lys Thr Asp Glu Lys 
                645                 650                 655     


Lys Leu Ile Lys Asn Arg Ile Lys Ser Glu Ile Ser His Thr Arg Tyr 
            660                 665                 670         


Leu Val Lys Lys Ala Asp Asn Ala Ser Lys Thr Asn Thr Thr Leu Lys 
        675                 680                 685             


Leu Gly Glu Met Ala Thr Glu Leu Ala Arg Asp Ile Thr Arg Met Val 
    690                 695                 700                 


Ile Asp Glu Asn Ile Lys Lys Lys Ile Thr Asn Pro Tyr Ala Asn Arg 
705                 710                 715                 720 


Leu Gln Asn Leu Ile Ala Tyr Phe Ser Leu Asn Lys Asn Glu Ile Val 
                725                 730                 735     


Gln Leu Leu Met Asn Glu Leu Lys Leu Phe Asp Thr Ala Lys Gly His 
            740                 745                 750         


Val Phe Leu Thr Arg Glu Leu Ile Glu Lys Ser Thr Gly Val Leu Asp 
        755                 760                 765             


Phe Tyr Ile Asn Tyr Phe Asn Lys Lys Ile Glu Tyr Phe Asp Ala Thr 
    770                 775                 780                 


Phe Lys Val Phe Leu Ala Ser Pro Ser Glu Tyr Glu Phe Lys Lys Ala 
785                 790                 795                 800 


Leu Pro Leu Lys Tyr Val Asn Leu Ile Lys Lys Thr Phe Glu Phe Asp 
                805                 810                 815     


Thr Val Lys Trp Phe Ala His Lys Asn Asn Met Pro Val Asn Ile Pro 
            820                 825                 830         


Phe Asn Leu Phe Asp Asn Leu Ile Asn Asn Lys Leu Lys Tyr Lys Ile 
        835                 840                 845             


Arg Glu Asn Thr Val Lys Met Thr Phe Ser Lys Leu Leu Glu Ile Tyr 
    850                 855                 860                 


Val Lys Tyr Asp Cys Gln Pro Phe Tyr Lys Phe Asn Arg Glu Tyr Asn 
865                 870                 875                 880 


Ser Val Glu Lys Asp Gln Thr Glu Ser Ile Asn Ile Leu Leu Leu Ser 
                885                 890                 895     


Ser Lys Asp Ile Gln Lys Asn Phe Ser Lys Arg Ala Val Asp Asn Glu 
            900                 905                 910         


Lys Gln Ile Arg Phe Thr Gln Ala Lys Asp Arg Ile Leu Lys Leu Met 
        915                 920                 925             


Ile Glu Gln Leu Ile Val Asp Ser Gly Ser Val Ile Ser Asp Ile Asp 
    930                 935                 940                 


Phe Asn Leu Glu Asp Ile Tyr Pro Gly Ser Glu Gln Ser Ala Leu Asn 
945                 950                 955                 960 


Ser Pro Ala Glu Phe Arg His Lys Leu Lys Arg Gln Gly Asn Asn Gly 
                965                 970                 975     


Glu Glu Phe Leu Thr Val Val Ala Lys Asp Ser Glu Ser Gln Ile Arg 
            980                 985                 990         


Gln Ile Lys Glu Trp Gly Glu Leu  Pro Lys Ala Glu Arg  Lys Ile Trp 
        995                 1000                 1005             


Asn Asn  Leu Lys Ser Lys Glu  Glu Lys Glu Glu Phe  Leu Lys Ser 
    1010                 1015                 1020             


Lys Asn  Asp Lys Glu Lys Leu  Thr Phe Asn Ala Gln  Gln Trp Tyr 
    1025                 1030                 1035             


Gln Trp  Thr Asn Ala Asp Phe  Gly Arg Phe Arg Arg  Phe Leu Lys 
    1040                 1045                 1050             


Asp Lys  Arg Ile Pro Lys Leu  Ser Lys Tyr Phe Glu  Ser Lys Thr 
    1055                 1060                 1065             


Ile Pro  Phe Asp Leu Leu Glu  Tyr Gln Leu Phe Gln  Tyr Thr Ile 
    1070                 1075                 1080             


Tyr Arg  Glu Lys Met Phe Asp  Lys Val Phe Glu Leu  Glu Lys Arg 
    1085                 1090                 1095             


Met Ser  Glu Leu Phe Leu Asn  Asp Leu Val Lys Ile  Lys Leu Gln 
    1100                 1105                 1110             


Lys Asn  Asp Thr Phe Pro Glu  Val Ser Phe Gln Asp  Tyr Ile Lys 
    1115                 1120                 1125             


Val Leu  Glu Asn Lys His Tyr  Ser Phe Asp Lys Phe  Ile Leu Ser 
    1130                 1135                 1140             


Met Gly  Arg Lys Ser Val Ser  His Thr Gln Val Val  Phe Tyr Asp 
    1145                 1150                 1155             


Lys Ile  Pro Arg Ile Thr Gln  Gln Asn Met Asp Glu  Phe Glu Ala 
    1160                 1165                 1170             


Arg Lys  Thr Glu Lys Gly Tyr  Lys Glu Asn Leu Thr  Phe Asn Ile 
    1175                 1180                 1185             


Pro Lys  Gln Ile Phe Glu Ile  Phe Ser Lys Glu Val  Asp Asn Val 
    1190                 1195                 1200             


Leu His  His Phe Asn Ile Asn  Leu Thr Ser 
    1205                 1210             


<210>  2367
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2367

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2368
<211>  1162
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2368

Met Glu Thr Thr Glu Asn Leu Lys Ser Tyr Asn Cys Gln Asn Ser Phe 
1               5                   10                  15      


Lys Arg Ile Phe Asp Phe Lys Gly Glu Ile Ala Pro Ile Ala Glu Lys 
            20                  25                  30          


Ala Cys Arg Asn Phe Glu Val Lys Ala Lys Asn Lys Val Asn Arg Glu 
        35                  40                  45              


Gln Arg Leu His Tyr Phe Ala Ile Gly His Thr Phe Lys His Ile Asp 
    50                  55                  60                  


Thr Glu Lys Leu Phe Lys Lys Thr Leu Asn Glu Glu Leu Arg Glu Lys 
65                  70                  75                  80  


Ile Pro Thr Gln Phe Leu Ala Leu Gln Ala Phe Asp Lys Ser Phe Cys 
                85                  90                  95      


Asp Glu Leu Glu Lys Ile Ile Ile Asp Lys Asp Asn Lys Lys Lys Tyr 
            100                 105                 110         


Gln Gly Ile Ile Pro Asp Ile Arg Asn Ile Asn Ser His Tyr Val His 
        115                 120                 125             


Asp Phe Gln Asn Ile Arg Leu Asp Thr Leu Ser Ser Cys Met Val Ser 
    130                 135                 140                 


Phe Ile Lys Glu Ser Phe Glu Leu Ala Ile Thr Gln Thr Tyr Leu Lys 
145                 150                 155                 160 


Glu Lys Glu Ile Ser Tyr Thr Gln Leu Ile Glu Gln Gly Asn Val Asp 
                165                 170                 175     


Lys Val Leu Val Ala Phe Met His Asp Lys Phe Tyr Pro Leu Asp Asp 
            180                 185                 190         


Lys Gly Ile Asn Leu Leu Glu Glu Ala Gln Arg Ser Leu Asp Glu Tyr 
        195                 200                 205             


Lys Thr Ile Arg Glu Lys Phe Lys Ser Leu Ser Lys Glu Asp Ala Ile 
    210                 215                 220                 


Asp Ser Leu Leu Phe Val Glu Val Asp Asn Asp Phe Asp Trp Lys Leu 
225                 230                 235                 240 


Tyr Gly Val His Pro Val Phe Lys Ile Thr Thr Gly Lys Tyr Leu Ser 
                245                 250                 255     


Phe Tyr Ala Cys Leu Phe Leu Leu Ser Met Phe Leu Tyr Lys Ser Glu 
            260                 265                 270         


Ala Glu Lys Leu Ile Gly Lys Ile Lys Gly Phe Lys Lys Gln Glu Lys 
        275                 280                 285             


Thr Glu Glu Lys Ser Lys Arg Arg Ile Phe Ser Phe Phe Ser Lys Lys 
    290                 295                 300                 


Phe Ser Ser Gln Asp Ile Asp Ser Glu Glu Asn His Leu Val Lys Phe 
305                 310                 315                 320 


Arg Asp Leu Ile Gln Tyr Leu Asn His Tyr Pro Leu Ala Trp Asn Lys 
                325                 330                 335     


Glu Leu Glu Leu Glu Ser Gln His Pro Ala Met Thr Asp Lys Leu Lys 
            340                 345                 350         


Ala Lys Ile Ile Glu Met Glu Ile Lys Arg Ser Phe Pro Ala Tyr Ser 
        355                 360                 365             


Asn Asn Glu Arg Phe His Val Phe Ala Lys Tyr Gln Ile Trp Gly Lys 
    370                 375                 380                 


Lys Tyr Phe Gly Lys Ser Ile Glu Gln Glu Tyr Ile Glu Gln Ser Phe 
385                 390                 395                 400 


Thr Glu Lys Glu Val Glu Gly Phe Asn Tyr Glu Ile Asp Ala Ser Pro 
                405                 410                 415     


Glu Leu Lys Asp Ala Asn Glu Lys Leu Asp Lys Leu Lys Ala Val Thr 
            420                 425                 430         


Gly Leu Tyr Gly Ala Lys Lys Asp Arg Asn Thr Lys Glu Ile Lys Lys 
        435                 440                 445             


Thr Glu Gly Ile Ile Asn Arg Ile Ile Arg Glu Lys Ala Pro Asn Pro 
    450                 455                 460                 


Val Lys Glu Lys Leu Lys Asn Arg Ile Glu Lys Asn Leu Leu Phe Val 
465                 470                 475                 480 


Ser Tyr Gly Arg Asn Gln Asp Arg Phe Met Asp Phe Ala Ile Arg Tyr 
                485                 490                 495     


Leu Ala Glu Thr Lys Tyr Phe Gly Glu Asp Ala Gln Phe Lys Thr Tyr 
            500                 505                 510         


Arg Phe Tyr Ser Thr Glu Glu Gln Asp Asp Glu Leu Leu Lys Leu Lys 
        515                 520                 525             


Glu Thr Gln Ser Lys Lys Glu Tyr Asp Lys Gln Lys Tyr His Gln Gly 
    530                 535                 540                 


Lys Pro Val His Phe Thr Thr Phe Lys Asp His Leu Glu His Tyr Glu 
545                 550                 555                 560 


Ser Trp Asp Thr Pro Phe Val Ile Glu Asn Asn Ala Val Gln Val Lys 
                565                 570                 575     


Leu Thr Phe Ala Thr Glu Ile Lys Lys Ile Val Ser Val Gln Arg Gly 
            580                 585                 590         


Leu Met Val Tyr Phe Leu Glu Asp Ala Leu Thr Lys Glu Ser Asp Lys 
        595                 600                 605             


Ile Glu Asn Ala Gly Lys Leu Leu Leu Glu Gly Tyr Tyr Ala Phe His 
    610                 615                 620                 


Gln Lys Glu Phe Ser Gln Cys Lys Ser Val Leu Glu Gln Ser Ser Ser 
625                 630                 635                 640 


Ile Ser Pro Glu Glu Lys Thr Ala Phe Lys Lys Leu Leu Pro Lys Arg 
                645                 650                 655     


Leu Leu Tyr His Tyr Ser Pro Ala Val Gln Asn Gly Lys Pro Gln Asn 
            660                 665                 670         


Thr Leu Val Leu Leu Leu Glu Arg Ala Thr Asp Ala Glu Lys Arg Tyr 
        675                 680                 685             


Gly Asn Leu Leu Thr Lys Ala Lys Ala Glu Gly Asn Tyr Asp Asp Phe 
    690                 695                 700                 


Val Lys Cys Asn Lys Gly Lys Gln Phe Lys Leu Gln Phe Ile Arg Lys 
705                 710                 715                 720 


Ala Trp His Leu Met Phe Phe Lys Glu Arg Tyr Met Gln Gln Ala Ala 
                725                 730                 735     


Phe Trp Gly His His Lys Arg Phe His Ile Ala Lys Asp Glu Phe Asn 
            740                 745                 750         


Asp Phe Ser Arg Phe Met Phe Ala Phe Asp Glu Val Pro His Tyr Lys 
        755                 760                 765             


Val Tyr Leu Ala Glu Met Phe Glu Lys Lys Gly Phe Phe Asp Asn Pro 
    770                 775                 780                 


Gly Phe Lys Thr Leu Phe Arg Asp Gly Val Ser Leu Asp Asp Leu Tyr 
785                 790                 795                 800 


Leu Lys Thr Lys Lys Ala Tyr Glu Ala Trp Leu Ser Lys Gln Val Ile 
                805                 810                 815     


Arg Val Gln Glu Glu Asn Lys Tyr Ala Leu Gly Asn Tyr Glu His Phe 
            820                 825                 830         


Phe Asp Asp Glu Met Phe Tyr Ile Asn Ile Ser His Phe Ile Asn Tyr 
        835                 840                 845             


Leu Glu Ala Lys Ser Gly Leu Lys Arg Asp Glu Arg Gly Leu Met Lys 
    850                 855                 860                 


Phe Thr Ala Leu Asp Asn Val Lys Phe Leu Ile Pro Glu Tyr Tyr Tyr 
865                 870                 875                 880 


Ala Asp Lys Leu Glu Lys Ala Glu Tyr Lys Thr Cys Gly Lys Leu Tyr 
                885                 890                 895     


Asn Lys Leu Lys Ser Ser Lys Leu Glu Asp Ala Leu Leu Phe Glu Met 
            900                 905                 910         


Ala Met His Tyr Leu Lys Ile Asp Lys Gln Ile Val Gln Lys Ala Lys 
        915                 920                 925             


Ser His Ala Thr Glu Ile Leu Lys Gln Asp Val Glu Phe Asp Ile Arg 
    930                 935                 940                 


Asp Leu Asn Ser Asn His Leu Tyr His Leu Met Val Pro Phe Asn Lys 
945                 950                 955                 960 


Ile Glu Ser Tyr Ile Gly Leu Ile Lys Leu Lys Glu Glu Gln Glu Glu 
                965                 970                 975     


Ser Lys Phe Lys Thr Ser Phe Leu Ala Asn Ile Val Ser Tyr Ile Glu 
            980                 985                 990         


Leu Val Lys Glu Lys Lys Glu Ile  Lys Ser Ile Tyr Lys  Thr Phe Ser 
        995                 1000                 1005             


Ala Asn  Pro Ala Lys Arg Ile  Leu Thr Phe Asp Glu  Leu Asn Lys 
    1010                 1015                 1020             


Ile Asp  Gly His Leu Ile Ser  Ser Ser Val Lys Phe  Thr Lys Leu 
    1025                 1030                 1035             


Ala Leu  Thr Leu Glu Gln Tyr  Tyr Val Asn Lys Cys  Met Leu Ser 
    1040                 1045                 1050             


Val Ile  Ala Asp His Arg Ile  Glu Tyr Gly Glu Ile  Lys Asp Leu 
    1055                 1060                 1065             


Lys Lys  Tyr Tyr Asn Thr Lys  Thr Arg Asn Lys Ala  Phe His Phe 
    1070                 1075                 1080             


Gly Val  Pro Glu Ser Ser Tyr  Asp Asn Ile Ile Ser  Lys Ile Glu 
    1085                 1090                 1095             


Gln Glu  Phe Val Arg Asn Glu  Ile Lys Ser Thr Gln  Pro His Lys 
    1100                 1105                 1110             


Phe Glu  Glu Leu Ser Lys Pro  Leu Lys Ser Ile Cys  Ser Leu Phe 
    1115                 1120                 1125             


Met Asp  Thr Ile His Asn Asn  Tyr Phe Asp Pro Ile  Glu Arg Asp 
    1130                 1135                 1140             


Gly Lys  Lys Lys His Lys Asp  Ala Glu Gln Lys Tyr  Phe Asp Thr 
    1145                 1150                 1155             


Val Ile  Ser Lys 
    1160         


<210>  2369
<211>  1047
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2369

Met Glu Glu Gln Phe Leu Gln Lys Glu Arg Asn Met Gly Asp Asn Pro 
1               5                   10                  15      


Tyr Tyr Phe Cys His Phe Ile Asn Met Ala His His Asn Val Asn Leu 
            20                  25                  30          


Ile Leu Glu Glu Ile Tyr Asn Ser Val Tyr Glu Lys Tyr Thr Gln Asp 
        35                  40                  45              


Lys Glu Glu Asn Ile Lys Ala Ile Cys Asn Ser Met Ile Ser Lys Ser 
    50                  55                  60                  


Arg Lys Asn Pro Asp Glu Lys Ala Lys Met Met Asn Met Cys Ile Arg 
65                  70                  75                  80  


His Phe Pro Phe Leu Asp Tyr Tyr Lys Glu Lys Asp Gln Asn Ser Asp 
                85                  90                  95      


Val Leu Thr Ile Leu Leu Asn Gln Phe Leu Val Pro Leu His Gly Leu 
            100                 105                 110         


Arg Asn Gln Phe Ser His Tyr Lys His Pro Gln Glu Ala Tyr Cys Ile 
        115                 120                 125             


Ser Gly Phe Asp Leu Leu Phe Glu Gln Ala Lys Thr Gly Ala Gln Met 
    130                 135                 140                 


Arg Met Lys Tyr Ser Asp Glu Asp Ile Ser Lys Val Lys Ser Lys Val 
145                 150                 155                 160 


Val Asn His Asp Ser Ile Leu Thr Glu Arg Gly Ile Leu Phe Phe Ile 
                165                 170                 175     


Cys Leu Phe Leu Asp Lys Arg Asn Ile Tyr Leu Phe Leu Ser Lys Ile 
            180                 185                 190         


Lys Gly Phe Arg Asp Arg Arg Pro Asp Glu Lys Tyr Lys Ser Ala Thr 
        195                 200                 205             


Leu Glu Val Phe Ser Gln Tyr Tyr Cys His Val Pro Tyr Arg Lys Leu 
    210                 215                 220                 


Asp Ser Ser Asp Val Ala Leu Asp Met Leu Asn Glu Leu Asn Arg Cys 
225                 230                 235                 240 


Pro Lys Ala Leu Tyr Asp Val Leu Ser Asp Glu Asp Arg Glu Arg Phe 
                245                 250                 255     


Ile Val Asp Asn Val Glu Asn Ala Asp Asn Arg Asp Glu Ile Ser Asp 
            260                 265                 270         


Glu Asp Asp Glu Glu Met Pro Arg Ser Val Met Lys Arg Ser Asp Asp 
        275                 280                 285             


Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Glu Lys Gln Asn Asn Leu 
    290                 295                 300                 


Asp Glu Ile Ser Phe His Leu Tyr Leu Gly Arg Lys Glu Ala Lys Pro 
305                 310                 315                 320 


Ala His Glu Lys Val Ile Asn Gly Glu Met Arg Thr His Lys Ile Leu 
                325                 330                 335     


Lys Asp Ile His Val Phe Gly Arg Leu Glu Asn Tyr Arg Asn Glu Glu 
            340                 345                 350         


Ile Cys Asn Ala Ile Lys Asn Arg Glu Asp Ile Glu Phe Tyr Ala Pro 
        355                 360                 365             


Ser Tyr Arg Ile Val Glu Asn Arg Ile Gly Leu Leu Leu Arg Arg Gln 
    370                 375                 380                 


Asn Asp Phe Thr Leu Glu Glu Ala Asn Glu Glu Lys Ile Phe Glu Gly 
385                 390                 395                 400 


Asn Leu Cys Pro Asp Val Ile Leu Ser Thr His Glu Leu Gly Ala Leu 
                405                 410                 415     


Phe Phe Tyr Asn Tyr Leu His Lys Lys Gly Trp Ile Glu Ser Ala Pro 
            420                 425                 430         


Tyr Leu Tyr Ile Arg Asn Phe Ile Ser Asp Phe Lys Arg Phe Ile Glu 
        435                 440                 445             


Asp Ile Lys Asn Gly Lys Leu Thr Pro Val Glu Ser Glu Asp Asp Phe 
    450                 455                 460                 


Tyr Leu Ile Lys Lys Lys Lys Arg Asp Glu Thr Lys Asp Asn Asp Lys 
465                 470                 475                 480 


Lys Ser Ile Ala Val Gln Glu Arg Arg Arg Glu Lys Leu Lys Glu Lys 
                485                 490                 495     


Leu Lys Gly Tyr His Leu Glu Pro Asp Trp Ile Pro Asp Ala Cys Arg 
            500                 505                 510         


Glu Tyr Met Leu Gly Tyr Lys Ala Asp Gln Lys Asp Tyr Tyr Thr Lys 
        515                 520                 525             


Gln Arg Phe Cys Ser Met Lys Lys Glu Thr Asp Ser Arg Ile Lys Gln 
    530                 535                 540                 


Ile Glu Ala Ile Arg Lys Arg Glu Asp Asn Ser Ile Ile Arg Gln Thr 
545                 550                 555                 560 


Arg Val Gly Glu Ile Ala Gln Glu Leu Ala Arg Asp Ile Val Phe Leu 
                565                 570                 575     


Ile Pro Pro Tyr Lys Asn Glu Lys Gly Ala Asp Thr Lys Ile Asn Asn 
            580                 585                 590         


Met Glu Phe Asp Val Leu Gln Lys Met Leu Ala Tyr Phe Pro Leu Asn 
        595                 600                 605             


Lys Lys Asp Ile Tyr Pro Phe Leu Lys Asn Ile Arg Asn Trp Asp Lys 
    610                 615                 620                 


His Pro Phe Leu Lys Tyr Thr Leu His Thr Glu His Gln Ser Leu Leu 
625                 630                 635                 640 


Asp Phe Tyr Gln Asp Tyr Leu Asn Cys Lys Lys Arg Trp Ile Ser Lys 
                645                 650                 655     


Asn Ile Arg Tyr Asp Lys Gln Lys Gly Asn Tyr Leu Val Asp Ala Asn 
            660                 665                 670         


Lys Thr Glu Gln Glu Cys Arg Tyr Phe Leu Lys Thr Asp Lys Leu Arg 
        675                 680                 685             


Thr Ala Lys Glu Lys Glu Tyr Phe Glu Glu Pro Asp Lys Pro Val Tyr 
    690                 695                 700                 


Leu Pro Thr Gly Phe Phe Val Asp Pro Ile Val Glu Ala Met Arg Lys 
705                 710                 715                 720 


Asn Gly Tyr Glu Leu Lys Glu Asn Ser Asn Ile Val Gly Cys Leu Lys 
                725                 730                 735     


Ile Tyr Phe Val Ser Lys Ile Gln Pro Met Tyr Asp Leu Ser Arg Tyr 
            740                 745                 750         


Tyr Thr Tyr Tyr Asp Gly Lys Glu Glu Arg Ser Met Gln Leu Asp Asp 
        755                 760                 765             


Leu Lys Val Phe Ile Lys Glu Lys Phe Gly Asn Lys Arg Thr Asp Asp 
    770                 775                 780                 


Asn Thr Ile Arg Phe Leu Lys Lys Ala Ala Lys Arg Ile Arg Glu Asn 
785                 790                 795                 800 


Glu Ser Glu Ile Leu Val Arg Gln Met Asp Asp Cys Ala Leu Phe Leu 
                805                 810                 815     


Met Val Asn Asp Leu Leu Glu Gly Gly Lys Phe Asn Asp Glu Asp Ile 
            820                 825                 830         


Glu Asn Ile Gly Tyr Asn Lys His His Asn Leu Leu Asp His Glu Tyr 
        835                 840                 845             


Asp Met Cys Glu Thr Ile Tyr Gly Arg Lys Val Thr Ala Arg Leu Pro 
    850                 855                 860                 


Ile Lys Arg Tyr Gly Glu Phe Arg Arg Phe Met Lys Asp Arg Arg Leu 
865                 870                 875                 880 


Gln Asn Leu Val Lys Tyr Tyr Pro Gly Asp His Glu Thr Pro Ile Pro 
                885                 890                 895     


Ser Gly Ile Pro Glu Ser Gly Lys Ala Met Glu Lys Asn Lys Lys Tyr 
            900                 905                 910         


Thr Tyr Ser Asn Leu Cys Asp Glu Leu Glu Ile Tyr Asp Lys Glu Arg 
        915                 920                 925             


Asp Asn Val Leu Asn Leu Ile Tyr Glu Val Asp Lys Ile Leu Val Asp 
    930                 935                 940                 


His Phe Pro Asp Lys Ile Met Lys Glu Glu Asp Gly Tyr Tyr Glu His 
945                 950                 955                 960 


Tyr His Cys Leu Asp Phe Ala Lys Lys Glu Phe Gly Leu Glu Ser Asp 
                965                 970                 975     


Val Glu Leu Leu Ser Gln Asp Asn Phe Lys Asp Leu Arg Asn Ala Leu 
            980                 985                 990         


Tyr His Asn Gln Ile Pro Tyr Asn  Asp Trp Val Ala Asp  Lys Ile Ser 
        995                 1000                 1005             


Lys Asp  Thr Glu Glu Pro Met  Tyr Val Arg Arg Ile  Phe Ser Phe 
    1010                 1015                 1020             


Ile Arg  Thr Val Tyr Ser Arg  Leu Leu Asp Gln Ile  Lys Ile Lys 
    1025                 1030                 1035             


Ile Glu  Lys Asp Glu Tyr Lys  Cys Lys 
    1040                 1045         


<210>  2370
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2370

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Leu Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2371
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2371

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2372
<211>  1052
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2372

Met Met Lys Thr Cys Ile Lys Asp Ser Trp Asn Lys Gln Ala Glu Lys 
1               5                   10                  15      


Leu Asp Lys Lys Val Arg Leu Arg Asn Leu Leu Met Arg His Phe Pro 
            20                  25                  30          


Phe Leu Glu Ala Ala Ala Tyr Glu Lys Thr Thr Ser Lys Asp Ser Asn 
        35                  40                  45              


Ser Lys Glu Gln Lys Glu Lys Glu Gln Ala Glu Ala Leu Ser Leu Asp 
    50                  55                  60                  


Asn Leu Lys Asn Val Leu Phe Ile Phe Leu Glu Lys Leu Gln Ser Leu 
65                  70                  75                  80  


Arg Asn Tyr Tyr Ser His Tyr Lys Tyr Ser Glu Glu Ala Gln Lys Pro 
                85                  90                  95      


Thr Phe Glu Asn Asp Leu Leu Lys Asn Met Tyr Lys Ile Phe Asp Thr 
            100                 105                 110         


Asn Val Arg Leu Val Lys Arg Asp Tyr Met His His Glu Asn Val Asp 
        115                 120                 125             


Met Gln Arg Asp Phe Ser His Leu Asn Arg Lys Lys Gln Glu Gly Gln 
    130                 135                 140                 


Thr Arg Lys Ile Ile Ala Asn Pro Asn Phe Arg Tyr His Phe Ala Asp 
145                 150                 155                 160 


Glu Lys Gly Asp Met Thr Ile Ala Gly Leu Leu Phe Phe Val Ser Leu 
                165                 170                 175     


Phe Leu Asp Lys Lys Asp Ala Ile Trp Met Gln Lys Lys Leu Lys Gly 
            180                 185                 190         


Phe Lys Asp Gly Arg Asn Leu Arg Glu Gln Met Thr Asn Glu Val Phe 
        195                 200                 205             


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Asn Val Gln 
    210                 215                 220                 


Thr Lys Asp Trp Met Gln Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
225                 230                 235                 240 


Pro Lys Ser Leu Tyr Glu Arg Leu Arg Glu Lys Asp Arg Glu Ser Phe 
                245                 250                 255     


Lys Val Pro Phe Asp Ile Phe Ser Asp Asp Tyr Asp Ala Glu Glu Glu 
            260                 265                 270         


Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe 
        275                 280                 285             


Val Leu Arg Tyr Phe Asp Leu Asn Glu Ile Phe Glu Gln Leu Arg Phe 
    290                 295                 300                 


Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile Tyr Asn Lys Arg Ile 
305                 310                 315                 320 


Gly Asp Glu Asp Glu Val Arg His Leu Thr His His Leu Tyr Gly Phe 
                325                 330                 335     


Ala Arg Ile Gln Asp Phe Ala Pro Gln Asn Gln Pro Glu Glu Trp Arg 
            340                 345                 350         


Lys Leu Val Lys Asp Leu Asp His Phe Glu Thr Ser Gln Glu Pro Tyr 
        355                 360                 365             


Ile Ser Lys Thr Ala Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly 
    370                 375                 380                 


Ile Lys Phe Cys Ser Thr His Asn Asn Leu Phe Pro Ser Leu Lys Arg 
385                 390                 395                 400 


Glu Lys Thr Cys Asn Gly Arg Ser Lys Phe Asn Leu Gly Thr Gln Phe 
                405                 410                 415     


Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Leu Pro Met Met Phe 
            420                 425                 430         


Tyr Tyr Leu Leu Leu Thr Lys Asp Tyr Ser Arg Lys Glu Ser Ala Asp 
        435                 440                 445             


Lys Val Glu Gly Ile Ile Arg Lys Glu Ile Ser Asn Ile Tyr Ala Ile 
    450                 455                 460                 


Tyr Asp Ala Phe Ala Asn Asn Glu Ile Asn Ser Ile Ala Asp Leu Thr 
465                 470                 475                 480 


Cys Arg Leu Gln Lys Thr Asn Ile Leu Gln Gly His Leu Pro Lys Gln 
                485                 490                 495     


Met Ile Ser Ile Leu Glu Gly Arg Leu Lys Asp Met Glu Lys Glu Ala 
            500                 505                 510         


Glu Arg Lys Ile Gly Glu Met Ile Asp Asp Thr Gln Arg Arg Leu Asp 
        515                 520                 525             


Leu Leu Cys Lys Gln Thr Asn Gln Lys Ile Arg Ile Gly Lys Arg Asn 
    530                 535                 540                 


Ala Gly Leu Leu Lys Ser Gly Lys Ile Ala Asp Trp Leu Val Ser Asp 
545                 550                 555                 560 


Met Met Arg Phe Gln Pro Val Gln Lys Asp Thr Asn Asn Ala Pro Ile 
                565                 570                 575     


Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu Gln His Ala 
            580                 585                 590         


Leu Ala Leu Phe Gly Ser Glu Ser Ser Arg Leu Lys Ala Tyr Phe Arg 
        595                 600                 605             


Gln Met Asn Leu Val Gly Asn Ala Asn Pro His Pro Phe Leu Ala Glu 
    610                 615                 620                 


Thr Gln Trp Glu His Gln Thr Asn Ile Leu Ser Phe Tyr Arg Asn Tyr 
625                 630                 635                 640 


Leu Glu Ala Arg Lys Lys Tyr Leu Lys Gly Leu Lys Pro Gln Asn Trp 
                645                 650                 655     


Lys Gln Tyr Gln His Phe Leu Ile Leu Lys Val Gln Lys Thr Asn Arg 
            660                 665                 670         


Asn Thr Leu Val Thr Gly Trp Lys Asn Ser Phe Asn Leu Pro Arg Gly 
        675                 680                 685             


Ile Phe Thr Gln Pro Ile Arg Glu Trp Phe Glu Lys His Asn Asn Ser 
    690                 695                 700                 


Lys Arg Ile Tyr Asp Gln Ile Leu Ser Phe Asp Arg Val Gly Phe Val 
705                 710                 715                 720 


Ala Lys Ala Ile Pro Leu Tyr Phe Ala Glu Glu Tyr Lys Asp Asn Val 
                725                 730                 735     


Gln Pro Phe Tyr Asp Tyr Pro Phe Asn Ile Gly Asn Lys Leu Lys Pro 
            740                 745                 750         


Gln Lys Gly Gln Phe Leu Asp Lys Lys Glu Arg Val Glu Leu Trp Gln 
        755                 760                 765             


Lys Asn Lys Glu Leu Phe Lys Asn Tyr Pro Ser Glu Lys Lys Lys Thr 
    770                 775                 780                 


Asp Leu Ala Tyr Leu Asp Phe Leu Ser Trp Lys Lys Phe Glu Arg Glu 
785                 790                 795                 800 


Leu Arg Leu Ile Lys Asn Gln Asp Ile Val Thr Trp Leu Met Phe Lys 
                805                 810                 815     


Glu Leu Phe Lys Thr Thr Thr Val Glu Gly Leu Lys Ile Gly Glu Ile 
            820                 825                 830         


His Leu Arg Asp Ile Asp Thr Asn Thr Ala Asn Glu Glu Ser Asn Asn 
        835                 840                 845             


Ile Leu Asn Arg Ile Met Pro Met Lys Leu Pro Val Lys Thr Tyr Glu 
    850                 855                 860                 


Thr Asp Asn Lys Gly Asn Ile Leu Lys Glu Arg Pro Leu Ala Thr Phe 
865                 870                 875                 880 


Tyr Ile Glu Glu Thr Glu Thr Lys Val Leu Lys Gln Gly Asn Phe Lys 
                885                 890                 895     


Val Leu Ala Lys Asp Arg Arg Leu Asn Gly Leu Leu Ser Phe Ala Glu 
            900                 905                 910         


Thr Thr Asp Ile Asp Leu Glu Lys Asn Pro Ile Thr Lys Leu Ser Val 
        915                 920                 925             


Asp His Glu Leu Ile Lys Tyr Gln Thr Thr Arg Ile Ser Ile Phe Glu 
    930                 935                 940                 


Met Thr Leu Gly Leu Glu Lys Lys Leu Ile Asp Lys Tyr Ser Thr Leu 
945                 950                 955                 960 


Pro Thr Asp Ser Phe Arg Asn Met Leu Glu Arg Trp Leu Gln Cys Lys 
                965                 970                 975     


Ala Asn Arg Pro Glu Leu Lys Asn Tyr Val Asn Ser Leu Ile Ala Val 
            980                 985                 990         


Arg Asn Ala Phe Ser His Asn Gln  Tyr Pro Met Tyr Asp  Ala Thr Leu 
        995                 1000                 1005             


Phe Ala  Glu Val Lys Lys Phe  Thr Leu Phe Pro Ser  Val Asp Thr 
    1010                 1015                 1020             


Lys Lys  Ile Glu Leu Asn Ile  Ala Pro Gln Leu Leu  Glu Ile Val 
    1025                 1030                 1035             


Gly Lys  Ala Ile Lys Glu Ile  Glu Lys Ser Glu Asn  Lys Asn 
    1040                 1045                 1050         


<210>  2373
<211>  985
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2373

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Asn Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys Gly Tyr 
                165                 170                 175     


Ala Phe Phe Ile Ser Lys Phe Leu Glu Arg Lys Tyr Ser Tyr Leu Phe 
            180                 185                 190         


Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln Tyr Arg 
        195                 200                 205             


Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro Val Glu 
    210                 215                 220                 


Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu Asp Ile 
225                 230                 235                 240 


Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr Leu Glu 
                245                 250                 255     


Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr Asp Ala 
            260                 265                 270         


Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe Arg Ser 
        275                 280                 285             


Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala Asp Phe 
    290                 295                 300                 


Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His Asn Gly 
305                 310                 315                 320 


Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr Ile Asn 
                325                 330                 335     


Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser Ala Lys 
            340                 345                 350         


Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser Thr Asp 
        355                 360                 365             


Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln Ser Thr 
    370                 375                 380                 


Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val Leu Pro 
385                 390                 395                 400 


Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala Lys Met 
                405                 410                 415     


Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala Met Leu 
            420                 425                 430         


Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His Cys Pro 
        435                 440                 445             


Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser Thr Lys 
    450                 455                 460                 


Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg Val Met 
465                 470                 475                 480 


Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu Arg Ile 
                485                 490                 495     


Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile Leu Lys 
            500                 505                 510         


Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp Leu Gln 
        515                 520                 525             


Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn Phe Gln 
    530                 535                 540                 


Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn Asp Leu 
545                 550                 555                 560 


Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn Pro His 
                565                 570                 575     


Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile Glu Phe 
            580                 585                 590         


Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg Ile Gln 
        595                 600                 605             


Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro Leu Arg 
    610                 615                 620                 


Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu Ala Ile 
625                 630                 635                 640 


Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys Leu Lys 
                645                 650                 655     


Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu Lys Ser 
            660                 665                 670         


Pro Ala Leu Asn Val Ser Tyr Leu Ile His Asn Tyr Phe Arg Ala Tyr 
        675                 680                 685             


Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn Tyr Arg 
    690                 695                 700                 


Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser Tyr Leu 
705                 710                 715                 720 


Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro Ser Lys 
                725                 730                 735     


Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp Arg Leu 
            740                 745                 750         


Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile Ile Arg 
        755                 760                 765             


Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys Glu Tyr 
    770                 775                 780                 


Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu Glu Asn 
785                 790                 795                 800 


Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp Leu Asn 
                805                 810                 815     


Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr Gly Lys 
            820                 825                 830         


Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn Lys Val 
        835                 840                 845             


Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val Lys Ile 
    850                 855                 860                 


Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu Glu Ala 
865                 870                 875                 880 


Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala Met Val 
                885                 890                 895     


Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr Tyr Asp 
            900                 905                 910         


Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln Lys Ile 
        915                 920                 925             


Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His Asp Lys 
    930                 935                 940                 


Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val Tyr Ala 
945                 950                 955                 960 


Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile Lys Leu 
                965                 970                 975     


Glu Asp Leu Ser Asn Asp Ser Ser Ala 
            980                 985 


<210>  2374
<211>  1141
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2374

Met Ala Gln Thr Arg Trp Lys Gln Ser Lys Thr Pro Ala Ile Lys Pro 
1               5                   10                  15      


Val Met Ala Ala Tyr Leu Asn Met Ala Arg His Asn Met Tyr Arg Val 
            20                  25                  30          


Met Leu His Ile Ser Arg Gln Met Gln Ile Ile Glu Asn Lys Glu Glu 
        35                  40                  45              


Ala Glu Ile Ala Ala Phe Ser Val Trp Gln Lys Leu Ser Ser Gly Thr 
    50                  55                  60                  


Pro Thr Glu Gln Met Lys Met Ile Lys Leu Leu Gln Arg His Phe Pro 
65                  70                  75                  80  


Val Leu Lys Pro Val Phe Asp Val Glu Lys Lys Lys Asn Val Glu Asn 
                85                  90                  95      


Ala Ala Ile Ser Ala Ser Pro Lys Glu Ile Lys Arg Ile Phe Thr Thr 
            100                 105                 110         


Ile Leu Thr Ala Leu Asn Arg Leu Arg Asn Glu Tyr Ser His Tyr Ser 
        115                 120                 125             


Pro Val Pro Arg Lys Thr Glu Gly Glu Glu Lys Met Ile Ala Tyr Leu 
    130                 135                 140                 


Tyr Arg Cys Met Asp Gly Ser Ala Arg Glu Val Arg Asn Arg Phe Ser 
145                 150                 155                 160 


Leu Thr Val Lys Asp Pro Lys Gly Ala Lys Glu Thr Ala Lys Val Leu 
                165                 170                 175     


Glu Val Asn Lys Ala Val Phe Asp Ile Phe Gln Asp Ala Phe Arg Lys 
            180                 185                 190         


Glu Lys Val Lys Ala Leu Asp Lys Ser Gly Lys Val Ile Lys Asp Asn 
        195                 200                 205             


Lys Gly Arg Thr Gln Phe Glu Phe Arg Asp Lys Glu Asp Tyr Tyr Tyr 
    210                 215                 220                 


Ala Leu Lys Asp Ala Asn Ala Ala Leu Ser Asp Met Gly Ile Val Phe 
225                 230                 235                 240 


Phe Thr Cys Leu Phe Leu Glu Lys Arg Tyr Ala Ala Met Phe Leu Asp 
                245                 250                 255     


Ala Ile Lys Pro Trp Pro Gln Asp Phe Asn Glu Ile Glu Arg Lys Ala 
            260                 265                 270         


Val Leu Glu Val Phe Thr Val Tyr His Ile His Leu Pro Lys Glu Lys 
        275                 280                 285             


Tyr Asp Ser Thr Arg Pro Glu Tyr Ala Leu Gly Leu Asp Met Leu Asn 
    290                 295                 300                 


Glu Leu Gln Lys Cys Pro Lys Glu Leu Phe Asp Ile Leu Ser Ala Lys 
305                 310                 315                 320 


Ser Arg Asp Ala Leu Ser Val Asp Ile Lys Ala Asp Arg Pro Asp Val 
                325                 330                 335     


Val Thr Asp Asp Gly Val Thr Val Lys Asp Gly Lys Val Gln Met Arg 
            340                 345                 350         


Arg Val Arg Asp Arg Phe Ala Pro Leu Ala Leu Gln Tyr Leu Asp Ser 
        355                 360                 365             


Gln Lys Ala Phe Asn Asp Ile Arg Phe Met Val Arg Leu Gly His Tyr 
    370                 375                 380                 


Arg Phe Lys Phe Tyr Lys Lys Gln Cys Val Ala Asp Asn Ala Pro Asp 
385                 390                 395                 400 


Thr Leu Arg Val Leu Gln Lys Glu Ile Asn Gly Phe Gly Arg Leu Asp 
                405                 410                 415     


Glu Met Glu Ala Ala Arg Lys Lys Asn Tyr Thr Pro Leu Phe Lys Ala 
            420                 425                 430         


Thr Cys Val Lys Thr Asn Asp Lys Gly Ile Glu Val His Glu Leu Val 
        435                 440                 445             


Pro Asp Ala Pro Asp Ser Ala Pro Tyr Ile Thr Asp Thr Lys Ala His 
    450                 455                 460                 


Tyr Leu Ile Asp Asn Asn Arg Val Gly Leu Arg Ile Asp Asn Pro Ser 
465                 470                 475                 480 


Phe Leu Pro Ser Leu Arg Gly Glu Lys Gly Ala Pro Ile Gln Ser Ala 
                485                 490                 495     


Gly Asp Ile Ser Leu Leu Ser Pro Gln Ala Trp Leu Ser Thr Tyr Glu 
            500                 505                 510         


Leu Pro Gly Leu Val Phe Tyr Gln Tyr Leu Tyr Asp Thr Tyr Asp Gly 
        515                 520                 525             


His Gly Lys His Leu Pro Ser Ala Glu Glu Ile Ile Lys Ser Tyr Ile 
    530                 535                 540                 


Leu Ala Tyr Lys Arg Leu Phe Val Asp Leu Gly Glu Gly Ser Phe Asp 
545                 550                 555                 560 


Gly Trp Asp Glu Tyr Ala Tyr Ala Pro Leu Thr Leu Gly Asp Leu Pro 
                565                 570                 575     


Gln Lys Ile Lys Gly Phe Ile Leu His Pro Ser Ala Thr Ile Asp Pro 
            580                 585                 590         


Arg Phe Gln Asp Lys Ala Asn Asn Arg Ile Asp Asp Met Ile Lys Arg 
        595                 600                 605             


Thr Glu Ala Glu Ile Ala Gly Phe Asp Thr Lys Met Lys Lys Leu Ser 
    610                 615                 620                 


Asp Lys Ser Asn Lys Leu Gly Lys Lys Lys Tyr Val Asp Ile Arg Pro 
625                 630                 635                 640 


Gly Ser Ile Ala Ser Arg Leu Val Arg Asp Ile Leu Phe Phe Thr Pro 
                645                 650                 655     


Val Ser Glu Glu Lys Ala Lys Ile Thr Ser Ala Asn Phe Asn Ser Leu 
            660                 665                 670         


Gln Ser Ala Leu Ala Leu Ser Glu Leu Gly Thr Asn Arg Ile Lys Asp 
        675                 680                 685             


Ile Leu Arg Gly Leu Asn His Pro Phe Val Met Lys Ala Phe Glu Lys 
    690                 695                 700                 


Tyr Arg Val Glu Asp Phe His Leu Phe Asp Phe Trp Lys Val Tyr Leu 
705                 710                 715                 720 


Asn Lys Arg Leu Asp Tyr Leu Lys Gly Leu Asp Arg Glu Lys Leu Glu 
                725                 730                 735     


Glu Val Pro Phe Leu His Ser Ser Arg Thr Arg Trp Gln Lys Arg Asp 
            740                 745                 750         


Glu Lys Tyr Ile Lys Leu Leu Ala Gly Arg Tyr Glu Gln Phe Glu Leu 
        755                 760                 765             


Pro Arg Ser Leu Phe Thr Ala Pro Thr Arg Val Leu Leu Asp Glu Val 
    770                 775                 780                 


Ala Leu His Phe Glu Ser Gly Ser Asp Arg Asp Leu Ser Met Gly Asn 
785                 790                 795                 800 


Leu Ile Asn Leu Phe Phe Ser Lys Val Leu Ser Asp Asn Asn Gln Pro 
                805                 810                 815     


Phe Tyr Arg Trp Glu Arg His Tyr Asp Val Phe Asp Lys Leu Ala Gly 
            820                 825                 830         


Val Lys Ser Gly Asn Ser Leu Val His Gln Phe Phe Lys Pro Glu Gln 
        835                 840                 845             


Leu Ala Lys Lys Met Arg Glu Arg Lys Thr Leu Lys Pro Ser Leu Tyr 
    850                 855                 860                 


Met Cys Glu Lys Ala Val Asn Ser Val Asn Gln Asn Leu Lys Lys Gly 
865                 870                 875                 880 


Glu Arg Arg Leu Asn Ile His Ser Ser Thr Asp Leu Lys Asp Ser Arg 
                885                 890                 895     


Val Ile Ala Val Ala Lys Glu Asn Leu Lys Lys Ala Tyr Gln Asp Tyr 
            900                 905                 910         


Asp Asp Asn Glu Arg Ile Leu Arg Arg Phe Ala Ile Gln Asp Lys Val 
        915                 920                 925             


Met Tyr Leu Met Ala Lys Ser Ile Leu Leu Gly Ile Lys Gly Ile Glu 
    930                 935                 940                 


Ala Gly Ser Leu Asp Arg Phe Lys Leu Lys Asp Ile Leu Pro Gly Lys 
945                 950                 955                 960 


Asn Asn Thr Ile Leu Asp Ile Leu Val Pro Phe Ser Ile Val Leu Glu 
                965                 970                 975     


Ile Asp Gly Ile Lys Val Leu Ile Arg Gln Lys Glu Lys Val Lys Ile 
            980                 985                 990         


Lys Arg Tyr Gly Glu Phe Phe Arg  Tyr Asn Thr Asp Thr  Arg Leu Arg 
        995                 1000                 1005             


Ser Leu  Leu Pro Leu Leu Gly  Lys Thr Leu Gly Ala  Glu Thr Glu 
    1010                 1015                 1020             


Ile Asn  Val Glu Leu Asp Arg  Asp Thr Leu Glu Glu  Glu Leu Ser 
    1025                 1030                 1035             


Ala Tyr  Asp Arg Glu Arg Val  Val Val Met Arg Met  Val Met Ser 
    1040                 1045                 1050             


Leu Glu  Gln Ser Ile Leu Ser  Arg Ser Thr Gly Asp  Val Pro Glu 
    1055                 1060                 1065             


Met Asp  Arg Glu Asn Phe Asn  Asn Leu Val Ser Lys  Val Gly His 
    1070                 1075                 1080             


Ile Pro  Tyr Lys Ser His Gly  Gln Ile Leu Ile Asn  Ile Arg Asn 
    1085                 1090                 1095             


Ser Phe  Cys His Asn Glu Tyr  Ala Arg Asp Ile Val  Leu Pro Glu 
    1100                 1105                 1110             


Gly Thr  Pro Leu Pro Gln Val  Ala Glu Thr Ile Ser  Lys Leu Phe 
    1115                 1120                 1125             


Glu Thr  Glu Arg Lys Arg Arg  Pro Asn Gln Cys Gln  Glu 
    1130                 1135                 1140     


<210>  2375
<211>  1128
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2375

Met Glu Ile Leu Thr Ile Pro Glu Val Ile Lys Cys Arg Thr Leu Ser 
1               5                   10                  15      


Asp Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Val Leu Asn Ile Ser Asn His Ile Ala Lys Glu Phe Lys Leu Pro Leu 
        35                  40                  45              


Leu Pro Glu Glu Ala His Leu Lys Asn Ser Phe Leu Cys Lys Lys Glu 
    50                  55                  60                  


Asn Lys Lys Ile Asp Trp Asn His Val Tyr Ala Arg Thr Ile Arg Phe 
65                  70                  75                  80  


Leu Ser Val Met Lys Val Phe Asp Ala Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Lys Thr Ile Asp Trp Glu Gly Lys Asp Phe Ala Ser Met Cys Asp 
            100                 105                 110         


Thr Leu Asn Ile Val Phe Ser Glu Leu Gln Glu Phe Ser Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Glu Thr Lys Arg Lys Thr Thr Val 
    130                 135                 140                 


Ser Asp Glu Leu Ala Leu Phe Leu Arg Thr Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Glu Tyr Thr Lys Val Arg Phe Lys Gly Ile Leu Asn Asp Glu Asp Tyr 
                165                 170                 175     


Gln Leu Val Val Ser Lys Lys Met Leu Glu Thr Asn His Thr Ile Thr 
            180                 185                 190         


His Glu Gly Leu Val Phe Leu Thr Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Arg Phe Ile Arg Lys Ile His Gly Leu Ser Gly Pro Lys Asp 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Cys Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro Gln Glu Gln Phe Arg Ser Asp Asn Arg Arg Gln Ala Ile Ser 
                245                 250                 255     


Leu Glu Leu Met Asn Glu Leu Lys Lys Cys Pro Lys Val Leu Tyr His 
            260                 265                 270         


Val Ile Thr Glu Glu Trp Lys Gln Lys Leu Lys Ser Val Pro Glu Glu 
        275                 280                 285             


Leu Glu Thr Lys Asn Leu His Tyr Asn Thr Lys Arg Glu Thr Lys Ile 
    290                 295                 300                 


Glu Phe Glu Asp Tyr Asp Leu Tyr Ile Glu Ser Leu Thr Lys Gln Val 
305                 310                 315                 320 


Arg Tyr Asn Asn Arg Phe Ser Glu Phe Ala Leu Lys Tyr Ile Asp Glu 
                325                 330                 335     


Thr Gly Ile Phe Ser Glu Phe Arg Phe Gln Leu Asp Leu Gly Lys Ile 
            340                 345                 350         


Leu Val Asp Glu Tyr Leu Lys Asn Phe Asn Asp Glu Arg Val Gln Arg 
        355                 360                 365             


Cys Ile Ile Glu Asn Ala Lys Ala Phe Gly Lys Leu Asn Asp Tyr Thr 
    370                 375                 380                 


Asn Glu Thr Lys Val Met Ser Leu Ile Val Asn Gly Pro Pro Leu Lys 
385                 390                 395                 400 


Ser Phe Asp Arg Phe Ala Pro His Tyr Asn Ile Glu Ser Asn Lys Ile 
                405                 410                 415     


Gly Ile Ser Thr His Glu Val Thr Ala Lys Leu Val Pro Asn Ser Lys 
            420                 425                 430         


Gly Glu Pro Ala Lys Lys Leu His Gln Pro Leu Pro Glu Ala Phe Leu 
        435                 440                 445             


Ser Leu His Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu Gln Lys 
    450                 455                 460                 


Gly Glu Pro Glu Lys Leu Ile Asn Glu Phe Ile Leu Val Asn Asn Ser 
465                 470                 475                 480 


Lys Leu Met Asn Met Ser Phe Ile Glu Glu Val Lys Asn Gln Leu Pro 
                485                 490                 495     


Lys Glu Trp Asp Lys Phe Gln Arg Arg Thr Asn Ala Lys His Glu Leu 
            500                 505                 510         


Ala Tyr Asp Glu Asn Thr Leu Ala Phe Leu Leu Gln Arg Lys Gln Ile 
        515                 520                 525             


Leu Asn Lys Thr Leu Leu Ala Tyr Gln Leu Asn Asp Lys Gln Ile Pro 
    530                 535                 540                 


Thr Arg Ile Leu Asp Tyr Trp Leu Asn Ile Ser Asp Ala Asp Glu Glu 
545                 550                 555                 560 


Arg Ala Ile Ser Asn Arg Leu Lys Ser Ile Lys Arg Asp Cys Met Ser 
                565                 570                 575     


Arg Leu Lys Ala Leu Ser Lys Phe Asn Glu Asn Gly Asn Arg Asn Lys 
            580                 585                 590         


Ile Pro Gly Ile Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile Ile 
        595                 600                 605             


Glu Met Val Val Ser Glu Gly Lys Lys Arg Lys Ile Thr Ser Phe Tyr 
    610                 615                 620                 


Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Gly Asp Pro Asp Lys 
625                 630                 635                 640 


Lys Gln Leu Phe Ile His Ile Val Thr Lys Glu Leu Lys Leu Asn Asp 
                645                 650                 655     


Pro Gly Gly His Pro Phe Leu Asp Lys Leu Asp Leu Gln Lys Ile Asn 
            660                 665                 670         


Ser Thr Thr Gly Phe Tyr Glu Ile Tyr Leu Gln Glu Lys Gly His Lys 
        675                 680                 685             


Met Val Pro Glu Asn Asn Pro Lys Thr Gly Lys Val Ile Tyr Thr Asp 
    690                 695                 700                 


His Ser Trp Met Ala Leu Thr Phe Tyr Lys Ile Glu Phe Asn Asp Lys 
705                 710                 715                 720 


Val Asp Met Leu Met Thr Val Val Lys Leu Pro Leu Lys Lys Leu Asn 
                725                 730                 735     


Ile Pro Phe Thr Leu Arg Gln Leu Ser Gly Lys Thr Asn Asn Thr Leu 
            740                 745                 750         


Lys Gln Trp Leu Asn Asn Leu Thr Gln Gly Lys Lys Arg Asn Asp Gly 
        755                 760                 765             


Lys Arg Pro Ile Asn Leu Pro Thr Asn Leu Phe Asp Glu Arg Leu Ala 
    770                 775                 780                 


Glu Leu Leu Arg Lys Asp Leu Asp Asn Lys Lys Ile Val Tyr Trp Pro 
785                 790                 795                 800 


Tyr Ala Asn Trp Asn Glu Leu Phe Lys Thr Trp Trp Ser Ser Arg Asn 
                805                 810                 815     


Asp Gly Leu Gln Ser Phe Tyr Asn Ala Glu Arg Glu Tyr Arg Ile Phe 
            820                 825                 830         


Asp Glu Lys Val Asn Phe Tyr Pro Asn Arg Lys Glu Asn Phe Ala Asp 
        835                 840                 845             


Tyr Tyr Gln His Ala Leu Lys Leu Ala Phe Gln Lys Lys Gln Ser Lys 
    850                 855                 860                 


Arg Ile Leu Glu Gln Met Tyr Asp Gln His Leu Pro Asp Ile Leu Phe 
865                 870                 875                 880 


Asp Gln Val Glu Lys Thr Phe Arg His Thr Ile Ala Glu Thr Glu Lys 
                885                 890                 895     


Glu Ile Arg Ile Leu Gln Glu Glu Asp His Ile Met Leu Leu Met Leu 
            900                 905                 910         


Glu Ser Leu Leu Asp Asp Gly Ser Lys Gln Gln Leu Lys Leu Ser Glu 
        915                 920                 925             


Ile Arg Thr His Leu Asn Arg Thr Thr Asn Ile Arg Gln Val Val Lys 
    930                 935                 940                 


Gly Lys Leu Ser Phe Asp Asp Ser Gly Glu Leu Ile Lys Asp Asn Thr 
945                 950                 955                 960 


Asn Ser Glu Ile Val Arg Thr Val Ser Val Thr Asp Gln Leu Lys Lys 
                965                 970                 975     


Phe His Leu Arg Pro Arg Phe Ile Ser Asp Ser Arg Leu Pro Glu Leu 
            980                 985                 990         


Phe Glu Tyr Phe Pro Asp Lys Glu  Ile Gln Met Glu Ser  Leu Lys Asn 
        995                 1000                 1005             


Glu Phe  Asp Thr Tyr Asn Ala  Ala Arg Gln Val Val  Leu Asn Leu 
    1010                 1015                 1020             


Ser Phe  Asn Leu Glu Lys Met  Ile Ile Glu Lys Gly  Arg Leu Asp 
    1025                 1030                 1035             


Arg Ile  Asn Gln Leu Leu Thr  Ser Ala Thr Gly Asp  Leu Leu Thr 
    1040                 1045                 1050             


Gly His  Ile Gly His Lys Thr  Tyr Leu Thr Trp Leu  Lys Asn His 
    1055                 1060                 1065             


Gly Ile  Ile Asp Asn Asp Thr  Phe Ile Phe Met Asn  Met Val Gln 
    1070                 1075                 1080             


Tyr Cys  Phe Ser His Asn Gln  Tyr Pro Gln Lys Lys  Thr Met Ala 
    1085                 1090                 1095             


Arg Leu  Ile Ser Arg Trp Asp  Gln His Arg Phe Ala  Leu Gln Ile 
    1100                 1105                 1110             


Glu Ala  Thr Tyr Ile Gln Lys  Ile Ala Gly Ile Ile  Glu Asp Leu 
    1115                 1120                 1125             


<210>  2376
<211>  1126
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2376

Met Glu Thr Leu Leu Thr Pro Thr Glu Asn Lys Tyr Arg Thr Ile Asn 
1               5                   10                  15      


Asp Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Ser Met Ala Arg Leu Asn 
            20                  25                  30          


Val Phe Asn Ile Ser Asn His Ile Ala Lys Glu Phe Gly Gln Ser Leu 
        35                  40                  45              


Leu Glu Glu Glu Gly His Ile Lys Asn Ser Phe Leu Cys Asp Lys Asn 
    50                  55                  60                  


Asn Lys Lys Val Asn Trp Asn His Val His Ala Lys Ala Arg Arg Phe 
65                  70                  75                  80  


Leu Ser Ile Leu Lys Val Phe Asp Ala Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Leu Lys Ile Ile Glu Trp Glu Gly Lys Asp Phe Ser Leu Met Gly Asp 
            100                 105                 110         


Thr Leu Lys Ile Val Phe Arg Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Phe Tyr Ser Thr Glu Lys Gly Thr Ser Arg Lys Ile Lys Val 
    130                 135                 140                 


Ser Glu Glu Leu Ala Glu Phe Leu Lys Thr Asn Phe Arg Arg Ala Ile 
145                 150                 155                 160 


Glu Tyr Thr Lys Glu Arg Phe Lys Gly Gly Leu Ile Glu Glu Asp Phe 
                165                 170                 175     


Asn Leu Val Ala Ser Arg Lys Val Val Arg Asp Asp Leu Ala Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ala Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Thr Gly Leu Lys Gly Thr Gln Asn 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro His Asp Arg Phe Gln Ser Asp Asn Thr Arg Gln Ala Phe Ser 
                245                 250                 255     


Leu Asp Leu Ile Asn Glu Leu Asn Arg Cys Pro Lys Val Leu Tyr Asn 
            260                 265                 270         


Val Ile Thr Glu Glu Gly Lys Gln Leu Phe Arg Pro Gln Leu Glu Asp 
        275                 280                 285             


Leu Glu Ile Lys Asn Leu Ile Lys Asn Ser Thr Asn Asn Glu Glu Glu 
    290                 295                 300                 


Ile Asp Asn Tyr Asp Glu Tyr Ile Glu Ala Leu Thr Lys Arg Ile Arg 
305                 310                 315                 320 


His Thr Asn Arg Phe Ser Asp Phe Ala Leu Gln Phe Ile Asp Glu Thr 
                325                 330                 335     


Asp Val Phe Lys Lys Phe Arg Phe Gln Ile Asp Leu Gly Lys Leu Leu 
            340                 345                 350         


Val Asp Glu Tyr Asp Lys Ser Phe Asn Gly Glu Glu Val Glu Arg Lys 
        355                 360                 365             


Ile Ile Val Asn Ala Lys Ala Phe Arg Lys Leu Asn Ser Tyr Gly Thr 
    370                 375                 380                 


Glu Asp Glu Thr Leu Lys Leu Ile Glu Asn Gly Gln Gly Ser Lys Arg 
385                 390                 395                 400 


Phe Glu Gln Phe Ala Pro His Tyr Asn Thr Glu Asn Asn Lys Ile Gly 
                405                 410                 415     


Leu Ser Gly Lys Glu Leu Ile Ala Lys Leu Arg Pro Asn Ser Lys Gly 
            420                 425                 430         


Glu Ala Gly Lys Lys Leu His Gln Pro Leu Pro Glu Ala Phe Leu Ser 
        435                 440                 445             


Leu Lys Glu Leu Pro Lys Ile Ile Leu Leu Asn Tyr Leu Leu Pro Asp 
    450                 455                 460                 


Glu Pro Glu Lys Leu Ile Asn Asp Phe Ile Leu Val Asn Asn Ser Lys 
465                 470                 475                 480 


Leu Met Asn Met Ser Phe Ile Lys Glu Val Lys Ser Leu Leu Pro Lys 
                485                 490                 495     


Glu Trp Asn Glu Phe Lys Lys Arg Ser Asp Thr Lys Lys Gln Arg Ala 
            500                 505                 510         


Tyr Asn Glu Lys Ala Leu Ala Tyr Leu Leu His Arg Lys Gln Ile Leu 
        515                 520                 525             


Asn Gln Val Leu Ala Ala Tyr Gln Leu Asn Asp Lys Gln Ile Pro Arg 
    530                 535                 540                 


Arg Ile Leu Asp Tyr Trp Leu Asn Ile Val Asp Val Val Glu Gly Arg 
545                 550                 555                 560 


Ser Val Ser Asp Arg Ile Lys Met Met Lys Arg Asp Cys Met Ser Arg 
                565                 570                 575     


Leu Lys Ala Met Ala Lys Phe Lys Glu Asp Arg Asn Arg Asn Lys Ile 
            580                 585                 590         


Pro Lys Ile Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile Val Asp 
        595                 600                 605             


Met Val Val Gly Glu Glu Lys Lys Gln Lys Ile Thr Ser Phe Tyr Tyr 
    610                 615                 620                 


Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Pro Glu Lys Lys 
625                 630                 635                 640 


Gln Leu Phe Ile His Thr Val Ile Asn Glu Leu Lys Leu Asn Glu Gln 
                645                 650                 655     


Gly Gly His Pro Phe Leu His Lys Leu Asn Leu Gln Gln Ile Lys Asn 
            660                 665                 670         


Thr Ser Gly Phe Tyr Glu Ile Tyr Leu Gln Glu Lys Gly Gln Lys Met 
        675                 680                 685             


Val Ser Glu Lys Asn Phe Arg Thr Gly Arg Thr Ile Glu Thr Asp Lys 
    690                 695                 700                 


Ser Trp Met Ala Leu Thr Phe Tyr Lys Lys Glu Trp Asp Glu Lys Val 
705                 710                 715                 720 


Gly Lys Gln Leu Thr Val Val Arg Leu Pro Glu Asn Lys Ser Asn Ile 
                725                 730                 735     


Pro Phe Ser Leu Arg Leu Leu Glu Glu Lys Thr Val Tyr Thr Leu Glu 
            740                 745                 750         


Gln Trp Leu His Asn Val Thr Lys Gly Lys Lys Gln Asn Asp Thr Arg 
        755                 760                 765             


Gln Pro Val Asn Leu Pro Thr Asn Leu Phe Asp Glu Arg Leu Thr Val 
    770                 775                 780                 


Leu Leu Arg Gly Glu Leu Asp Lys Lys Gln Ile Ser Tyr Ala Pro Asn 
785                 790                 795                 800 


Ala Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Lys Ser Arg Asn Asp 
                805                 810                 815     


Ser Val Gln Ser Phe Tyr Lys Ala Glu Arg Glu Tyr Glu Ile Phe Gly 
            820                 825                 830         


Glu Lys Val Asn Phe Met Pro Asp Ser Lys Glu Arg Phe Ala Asp Tyr 
        835                 840                 845             


Tyr Gln His Ala Leu Thr Ala Ala Trp Gln Lys Lys Arg Lys Glu Arg 
    850                 855                 860                 


Ile Gln Gln Gln Lys Gln Asp Arg Arg Leu Pro Asp Ile Ser Phe Asp 
865                 870                 875                 880 


Gln Val Glu Lys Thr Phe Lys Gln Thr Ile Ala Glu Thr Glu Lys Glu 
                885                 890                 895     


Ile Arg Ile Val Gln Glu Glu Asp Arg Met Met Leu Leu Met Leu Glu 
            900                 905                 910         


Thr Leu Met Glu Asn Gly Lys Asp Leu Lys Leu Lys Leu Ser Gly Ile 
        915                 920                 925             


Asp Thr Leu Leu Asn Ala Thr Thr Glu Val Lys Gln Leu Val Ser Gly 
    930                 935                 940                 


Lys Leu Ser Phe Asn Gly Ser Gly Glu Leu Ile Lys Gly Lys Thr Asn 
945                 950                 955                 960 


Pro Glu Ile Ser Lys Thr Ile Thr Val Ala Arg Lys Arg Lys Asp Tyr 
                965                 970                 975     


Ser Met Leu Arg Lys Phe Val Phe Asp Arg Arg Leu Pro Glu Leu Phe 
            980                 985                 990         


Glu Tyr Phe Ala Glu Glu Glu Ile  Pro Ile Glu Val Leu  Lys Asp Glu 
        995                 1000                 1005             


Leu Asp  Ala Tyr Asn Lys Ala  Lys His Glu Val Phe  Asp Thr Val 
    1010                 1015                 1020             


Phe Glu  Leu Glu Glu Lys Ile  Ile Thr Leu Asp Ala  Asp Gly Ile 
    1025                 1030                 1035             


Arg Gln  Leu Phe Ile Asp Asp  Ala Gly Gln Pro Val  Thr Gly Asn 
    1040                 1045                 1050             


Ile Gln  His Lys Pro Tyr Val  Ile Trp Leu Lys Asn  Asn Gly Thr 
    1055                 1060                 1065             


Ile Asp  Asp Asn Thr Leu Thr  Phe Leu Asn Met Val  Arg Asn Cys 
    1070                 1075                 1080             


Phe Ser  His Asn Gln Tyr Pro  Gln Lys Lys Thr Met  Glu Leu Leu 
    1085                 1090                 1095             


Ile Gly  Gln Trp Glu Pro Asn  Arg Phe Ala Leu Thr  Ile Ala Gln 
    1100                 1105                 1110             


Thr Tyr  Lys Arg Lys Ile Asn  Ser Ile Met Lys His  Leu 
    1115                 1120                 1125     


<210>  2377
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2377

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2378
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2378

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2379
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2379

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2380
<211>  1285
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2380

Met Ala Phe Asp Lys Pro Arg Pro Lys Arg Arg Gln Ala Arg Ser Asp 
1               5                   10                  15      


Phe Tyr Ile Thr Asp Lys Ala Ile Met Gly Gly Tyr Phe Asn Leu Ala 
            20                  25                  30          


Gln Leu Asn Phe Phe Lys Thr Leu Met Glu Ile Phe Thr Lys Ala Gly 
        35                  40                  45              


Ile Asp Val Ser Lys Ile Lys Gln Asp Asn Ser Pro Lys Tyr Leu Met 
    50                  55                  60                  


Ile Leu Ile Lys Lys Leu Thr His Asp Asp Glu Lys Ile Asp Asp Lys 
65                  70                  75                  80  


Lys Trp Ala Asp Ala Leu Asp Leu Ser Asn Glu Cys Leu Leu Lys Leu 
                85                  90                  95      


Gln Gln Leu Leu Tyr Lys His Phe Pro Phe Leu Gly Pro Val Met Gly 
            100                 105                 110         


Gly Glu Ala Ser Tyr Asn Ile Tyr Lys Leu Lys Asp Gly His Pro Glu 
        115                 120                 125             


Val Lys Val Ala Asn Asp Val Met Arg Gly Val Lys Leu Glu Asp Cys 
    130                 135                 140                 


Leu Thr Val Leu Arg His Phe Ala Leu Cys Leu Asn Asp Cys Arg Asn 
145                 150                 155                 160 


Phe Tyr Thr His Phe Asn Pro Tyr Asn Ser Ile Asp Ala Gln Lys Glu 
                165                 170                 175     


Gln Tyr Leu Ser Gln Asn Lys Val Ala Val Trp Leu Asp Lys Val Lys 
            180                 185                 190         


Asp Ala Ser Arg Arg Ile Val Lys Gln Asn Asn Gln Leu Thr Ser Gln 
        195                 200                 205             


Asp Met Glu Phe Leu Thr Gly Ile Asp His Met Lys Pro Gln Asp Lys 
    210                 215                 220                 


Val Asp Glu Phe Gly Asn Ile Met Thr Asp Arg Arg Gly Tyr Thr Ile 
225                 230                 235                 240 


Lys Glu Tyr Val Glu Tyr Glu Asp Tyr Tyr Phe Arg Ile Arg Gly Lys 
                245                 250                 255     


Arg Tyr Leu Val Asp Ala Ala Gly Ala Lys Leu Ala Asp Gln Glu Pro 
            260                 265                 270         


Arg Asn Ala Leu Ser Asp Phe Gly Val Val Phe Leu Cys Thr Phe Phe 
        275                 280                 285             


Leu Glu Ser Asp Gln Ser Arg Arg Met Leu Asp Glu Leu Arg Leu Phe 
    290                 295                 300                 


Glu Thr Gly Pro Tyr Asp Gly Ser Arg Asp Gly Asp Glu Phe Lys Asn 
305                 310                 315                 320 


Asp Ile Leu Arg Glu Ile Leu Leu Phe Tyr Arg Ala Arg Ile Pro Arg 
                325                 330                 335     


Gly Lys Arg Leu Asp Pro Met Asp Asp Thr Thr Leu Leu Ala Met Asp 
            340                 345                 350         


Met Leu Asn Glu Leu Arg Lys Cys Pro Met Pro Leu Tyr Asp Val Leu 
        355                 360                 365             


Ser Arg Glu Gly Gln Arg Phe Phe Glu Asp Glu Val Lys Arg Pro Asn 
    370                 375                 380                 


Asp Leu Thr Pro Glu Val Ala Lys Arg Leu Arg Ser Ser Asp Arg Phe 
385                 390                 395                 400 


Pro Tyr Leu Ala Leu Arg Tyr Ile Asp Leu Asn Lys Cys Phe Asp Asn 
                405                 410                 415     


Ile Arg Phe Gln Val Gln Leu Gly Lys Phe Arg Tyr Lys Phe Tyr Asp 
            420                 425                 430         


Lys Thr Thr Ile Asp Gly Glu Gln Val Val Arg Gly Leu Gln Lys Glu 
        435                 440                 445             


Val Asn Ala Tyr Gly Arg Leu Gln Asp Val Glu Arg Tyr Arg Gln Glu 
    450                 455                 460                 


Lys Tyr Ala Asp Met Leu Gln Gln Thr Glu Leu Val Glu Thr Gly Glu 
465                 470                 475                 480 


Glu Asp Ile Thr Ile Ala Asn Phe Ile Pro Asp Thr Pro Gln Ser Ser 
                485                 490                 495     


Pro Tyr Leu Ser Asp Arg Thr Ala Ser Tyr Asn Ile His Asn Asn Arg 
            500                 505                 510         


Ile Gly Leu Phe Trp Asn Met Pro Gly Glu Gln Glu Val Leu Thr Gly 
        515                 520                 525             


Asp Glu Lys Met Tyr Leu Pro Asp Leu Asn Val Asp Asp Asn Gly Lys 
    530                 535                 540                 


Ala Asp Val Phe Leu Pro Ala Pro Lys Ala Ser Leu Ser Val Arg Asp 
545                 550                 555                 560 


Leu Pro Ala Leu Val Phe Tyr Leu Tyr Leu Gln Asn Gln His Pro Asp 
                565                 570                 575     


Leu Met Pro Ala Glu Ser Ile Ile Gln Gln Lys Tyr Asn Ala Leu Val 
            580                 585                 590         


Arg Phe Phe Glu Asp Val Ser Thr Gly Arg Leu Gln Pro Val Lys Gly 
        595                 600                 605             


Ile Asn Glu Leu Lys Ala Ala Ile Asp Arg Tyr Glu Tyr Leu Thr Ile 
    610                 615                 620                 


His Glu Ile Pro Glu Lys Leu Arg Asp Tyr Leu Ala Gly Val Ala Gly 
625                 630                 635                 640 


Thr Glu Asp Asp Asp Asp Cys Ala Asp Arg Leu Asp Cys Tyr Ala Met 
                645                 650                 655     


Gly Ile Leu Glu Lys Arg Tyr Arg Arg Val Ala Ala Arg Ile Asp Gln 
            660                 665                 670         


Leu Lys Glu Ala Arg Lys Met Val Gly Asp Lys Met Asn Arg Tyr Gly 
        675                 680                 685             


Lys Lys Ser Tyr Ile Asp Val Arg Pro Arg Arg Leu Ala Glu Gln Leu 
    690                 695                 700                 


Ala Gln Ser Ile Val Glu Trp Gln Pro Ala Thr Asp Asn Gly Arg His 
705                 710                 715                 720 


Lys Met Thr Gly Lys Asn Phe Gln Arg Leu Ile Ala Phe Leu Ala Arg 
                725                 730                 735     


Tyr Thr Asp Glu Val Pro Leu Gln Glu Ile Lys Asp Leu Met Ser Arg 
            740                 745                 750         


Ala Arg Leu Leu Asp Gly Pro Val Ala His Pro Phe Leu Gln Gln Val 
        755                 760                 765             


Leu Asp Lys Asn Pro Leu Asn Ile Glu Val Leu Tyr Asp Leu Tyr Phe 
    770                 775                 780                 


Lys Glu Glu Lys Arg Tyr Leu Asp Lys Tyr Ile Glu Ile Glu Ile Lys 
785                 790                 795                 800 


Glu Val Phe Arg Lys Lys Ala Ser Val Asp Leu Ser Arg Ile Pro Phe 
                805                 810                 815     


Leu Asn Ser Gly Arg Leu Arg Phe His Lys Arg Asp Ser Ala Tyr Tyr 
            820                 825                 830         


Gln Arg Leu Ala Ala Arg Tyr Leu Lys Val Asp Gly Arg Gln Ser Thr 
        835                 840                 845             


Ile Leu Leu Pro Asp Gly Leu Phe Thr Pro His Ile Leu Ser Ala Leu 
    850                 855                 860                 


Lys Ser Ile Leu Tyr Gln Glu Asn Arg Asp Leu Gln Asp His Leu Gln 
865                 870                 875                 880 


Asp Gln Glu Leu Asn Arg Asn Ala Ser Tyr Leu Met Ser Ala Tyr Leu 
                885                 890                 895     


Glu His Val Leu His Asp Ser Ala Gln Pro Phe Tyr Leu Ser Asn Ser 
            900                 905                 910         


Asn Asp Ser His Phe Ala Arg Arg Tyr Asp Leu Phe Ala Ile Met Gln 
        915                 920                 925             


Asn Lys Lys Lys Gly Ala Glu Leu Leu Pro Ser Pro Leu Thr Pro Val 
    930                 935                 940                 


Glu Ile Asn Arg Arg Ile Thr Gly Lys Thr Pro Asp Gly Ser Ala Lys 
945                 950                 955                 960 


Val Ile Glu His Asp Ile Lys Ala Leu Leu Asp Gly Met Ala His Lys 
                965                 970                 975     


Thr Glu Glu Arg Ile His Asp Leu Gln Gln Asp Tyr Ser Arg Lys Lys 
            980                 985                 990         


Glu Gln Gln Val Gln Glu Glu Arg  Val Lys Leu Glu Arg  Tyr Phe Met 
        995                 1000                 1005             


Arg Lys  Ile Ala Asp Val Lys  Asn Gln Ala Gln Glu  Glu Arg Ile 
    1010                 1015                 1020             


Lys Leu  Gln Arg Arg Leu Lys  His Lys Ile Thr Asp  Val Lys Lys 
    1025                 1030                 1035             


Asn Glu  Arg Thr Ile Arg Arg  Tyr Lys Thr Gln Asp  Met Ala Ile 
    1040                 1045                 1050             


Phe Leu  Met Ala Gln Gln Met  Leu Ala Asn Gln Leu  Ser Trp Gln 
    1055                 1060                 1065             


Asn Gln  Glu Gly Glu Val Pro  Phe Lys Leu Ala Asn  Val Cys Asn 
    1070                 1075                 1080             


Asp Gly  Phe Leu Arg Gln Thr  Met Lys Ile Ser Phe  Pro Tyr Glu 
    1085                 1090                 1095             


Val Pro  Leu Lys Glu Asp Lys  Thr Lys Lys Val Thr  Ile Asp Ile 
    1100                 1105                 1110             


Val His  Asp Asn Met Ser Leu  Lys Asn Tyr Gly Leu  Leu Tyr Lys 
    1115                 1120                 1125             


Leu Tyr  His Asp Glu Arg Val  Val Thr Leu Leu Gln  Asn Ile Val 
    1130                 1135                 1140             


Asp Gln  Gln Gln Ile Ser Phe  Ala Glu Leu Thr Ala  Glu Leu Ser 
    1145                 1150                 1155             


Leu Tyr  Asp Gln Asn Arg Ser  Lys Ala Phe Ser Asn  Phe Gln Gln 
    1160                 1165                 1170             


Phe Glu  Arg Leu Ala Phe Glu  Thr Asn Lys Glu Ala  Leu Ser Asn 
    1175                 1180                 1185             


Pro Glu  His Ser Gly Phe Phe  Leu Glu Lys Val Asn  Lys Lys Asn 
    1190                 1195                 1200             


Gln Val  Ile Arg Tyr Glu Arg  Arg Asn Asn Phe Asp  Ala Leu Leu 
    1205                 1210                 1215             


Asp Leu  Leu Asp Ala Ile Glu  Ala His Gln Leu Asn  Pro Arg Glu 
    1220                 1225                 1230             


Arg Gln  Trp Leu Thr Ser Val  Arg Asn Ala Phe Cys  His Asn Ser 
    1235                 1240                 1245             


Tyr Tyr  Lys Ile Asp Met Gln  Gln Ile Glu Lys Lys  Leu Pro Thr 
    1250                 1255                 1260             


Ile Ile  Gln Gln Ile Val Glu  Ile Val Gln Arg Ile  Thr Asp Lys 
    1265                 1270                 1275             


Ala Ser  His Pro Ser Asn Gln  
    1280                 1285 


<210>  2381
<211>  1175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2381

Met Thr Glu Gln Asn Glu Arg Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Ala His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Cys Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Glu Lys Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Ala Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Ala 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Leu Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Glu Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Gly Glu Ile Asp Thr Arg Asp 
    530                 535                 540                 


Glu Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Glu Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Ser Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Leu Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Asp Leu Glu Ala Trp Ser His Ser Ala Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Val Gly Ile Glu Tyr Ala Ser Trp Glu Asn 
    850                 855                 860                 


Lys Lys Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Glu Thr 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Lys Ala Asp Lys Ile Asn Ile Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Ala Lys Glu His Pro Tyr Leu Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Met 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asp Ile Arg Thr 
945                 950                 955                 960 


Glu Val Gln Glu Gln Gly Ser Leu Asn Val Leu Asn Arg Val Lys Pro 
                965                 970                 975     


Met Arg Leu Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val 
            980                 985                 990         


His Lys Glu Gln Ala Pro Leu Ala  Thr Val Tyr Ile Glu  Glu Arg Asp 
        995                 1000                 1005             


Thr Lys  Leu Leu Lys Gln Gly  Asn Phe Lys Ser Phe  Val Lys Asp 
    1010                 1015                 1020             


Arg Arg  Leu Asn Gly Leu Phe  Ser Phe Val Asp Thr  Gly Ala Leu 
    1025                 1030                 1035             


Ala Met  Glu Gln Tyr Pro Ile  Ser Lys Leu Arg Val  Glu Tyr Glu 
    1040                 1045                 1050             


Leu Ala  Lys Tyr Gln Thr Ala  Arg Val Cys Ala Phe  Glu Gln Thr 
    1055                 1060                 1065             


Leu Glu  Leu Glu Glu Ser Leu  Leu Thr Arg Tyr Pro  His Leu Pro 
    1070                 1075                 1080             


Asp Lys  Asn Phe Arg Lys Met  Leu Glu Ser Trp Ser  Asp Pro Leu 
    1085                 1090                 1095             


Leu Asp  Lys Trp Pro Asp Leu  His Arg Lys Val Arg  Leu Leu Ile 
    1100                 1105                 1110             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1115                 1120                 1125             


Glu Thr  Ile Phe Ser Ser Ile  Arg Lys Tyr Asp Pro  Ser Ser Pro 
    1130                 1135                 1140             


Asp Ala  Ile Glu Glu Arg Met  Gly Leu Asn Ile Ala  His Arg Leu 
    1145                 1150                 1155             


Ser Glu  Glu Val Lys Gln Ala  Lys Glu Met Val Glu  Arg Ile Ile 
    1160                 1165                 1170             


Gln Ala  
    1175 


<210>  2382
<211>  975
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2382

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Asn Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys Gly Tyr 
                165                 170                 175     


Ala Phe Phe Ile Ser Lys Phe Leu Glu Arg Lys Tyr Ser Tyr Leu Phe 
            180                 185                 190         


Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln Tyr Arg 
        195                 200                 205             


Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro Val Glu 
    210                 215                 220                 


Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu Asp Ile 
225                 230                 235                 240 


Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr Leu Glu 
                245                 250                 255     


Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr Asp Ala 
            260                 265                 270         


Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe Arg Ser 
        275                 280                 285             


Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala Asp Phe 
    290                 295                 300                 


Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His Asn Gly 
305                 310                 315                 320 


Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr Ile Asn 
                325                 330                 335     


Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser Ala Lys 
            340                 345                 350         


Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser Thr Asp 
        355                 360                 365             


Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln Ser Thr 
    370                 375                 380                 


Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val Leu Pro 
385                 390                 395                 400 


Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala Lys Met 
                405                 410                 415     


Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala Met Leu 
            420                 425                 430         


Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His Cys Pro 
        435                 440                 445             


Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser Thr Lys 
    450                 455                 460                 


Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg Val Met 
465                 470                 475                 480 


Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu Arg Ile 
                485                 490                 495     


Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile Leu Lys 
            500                 505                 510         


Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp Leu Gln 
        515                 520                 525             


Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn Phe Gln 
    530                 535                 540                 


Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn Asp Leu 
545                 550                 555                 560 


Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn Pro His 
                565                 570                 575     


Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile Glu Phe 
            580                 585                 590         


Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg Ile Gln 
        595                 600                 605             


Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro Leu Arg 
    610                 615                 620                 


Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu Ala Ile 
625                 630                 635                 640 


Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys Leu Lys 
                645                 650                 655     


Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu Lys Ser 
            660                 665                 670         


Pro Ala Leu Asn Val Ser Tyr Leu Ile His Asn Tyr Phe Arg Ala Tyr 
        675                 680                 685             


Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn Tyr Arg 
    690                 695                 700                 


Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser Tyr Leu 
705                 710                 715                 720 


Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro Ser Lys 
                725                 730                 735     


Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp Arg Leu 
            740                 745                 750         


Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile Ile Arg 
        755                 760                 765             


Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys Glu Tyr 
    770                 775                 780                 


Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu Glu Asn 
785                 790                 795                 800 


Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp Leu Asn 
                805                 810                 815     


Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr Gly Lys 
            820                 825                 830         


Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn Lys Val 
        835                 840                 845             


Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val Lys Ile 
    850                 855                 860                 


Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu Glu Ala 
865                 870                 875                 880 


Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala Met Val 
                885                 890                 895     


Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr Tyr Asp 
            900                 905                 910         


Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln Lys Ile 
        915                 920                 925             


Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His Asp Lys 
    930                 935                 940                 


Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val Tyr Ala 
945                 950                 955                 960 


Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile Lys 
                965                 970                 975 


<210>  2383
<211>  1312
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2383

Met Gly Lys Gly Asn Lys Gly Asn Glu Val Lys Ile Gln Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Arg Ile Gln Lys Thr Asn Phe Thr Ile Ser Leu Thr Gly 
            20                  25                  30          


Lys His Val Phe Gly Ala Tyr Phe Asn Met Ala Arg Thr Asn Phe Ile 
        35                  40                  45              


Lys Thr Ile Asn Tyr Ile Leu Pro Ile Ala Gly Val Arg Gly Asn Tyr 
    50                  55                  60                  


Ser Glu Asn Gln Ile Asn Asn Met Leu His Ala Leu Phe Leu Ile His 
65                  70                  75                  80  


Ala Gly Arg Asn Ser Glu Leu Ser Lys Glu Gln Lys Gln Trp Glu Lys 
                85                  90                  95      


Lys Leu Arg Leu Asn Leu Glu Gln Gln Thr Lys Leu Gln Lys Leu Leu 
            100                 105                 110         


Phe Lys His Phe Pro Val Leu Gly Pro Met Met Ala Asp Val Ala Asp 
        115                 120                 125             


His Lys Ala Phe Leu Asn Lys Lys Lys Ser Lys Val Gln Thr Glu Asp 
    130                 135                 140                 


Glu Ala Phe Val Gln Leu Lys Gly Val Ser Leu Ser Asp Cys Leu Glu 
145                 150                 155                 160 


Met Ile His Leu Met Ala Ile Thr Leu Thr Glu Cys Arg Asn Phe Tyr 
                165                 170                 175     


Thr His Lys Ser Pro Tyr Asn Thr Pro Ser Gln Leu Ala Ser Gln Tyr 
            180                 185                 190         


Gln His Gln Glu Gln Ile Ala Lys Lys Leu Asp Lys Val Val Val Ala 
        195                 200                 205             


Ser Arg Arg Ile Leu Lys Asp Arg Glu Gly Leu Ser Ile Asn Glu Val 
    210                 215                 220                 


Glu Phe Leu Thr Gly Ile Asp His Leu His Gln Glu Ile Glu Lys Asp 
225                 230                 235                 240 


Gln Phe Gly Asn Ile Val Lys Lys Asn Gly Lys Val Leu Lys Thr Phe 
                245                 250                 255     


Val Glu Tyr Asp Asp Phe Tyr Phe Lys Ile Phe Gly Lys Arg Leu Val 
            260                 265                 270         


Lys Gly Leu Thr Val Ala Val Lys Asp Asn Asp Pro Val Asn Val Asp 
        275                 280                 285             


Thr Met Leu Pro Ala Leu Ser Asp Phe Gly Leu Leu Tyr Phe Cys Val 
    290                 295                 300                 


Leu Phe Leu Ser Lys Pro Tyr Ala Lys Leu Phe Ile Asp Glu Thr Arg 
305                 310                 315                 320 


Leu Phe Glu Phe Ser Pro Phe Asn Asp Asn Glu Asn Met Ile Leu Ser 
                325                 330                 335     


Glu Met Leu Ser Ile Tyr Arg Ile Arg Thr Pro Arg Leu His Lys Ile 
            340                 345                 350         


Asp Ser Arg Asp Asn Lys Ala Ala Leu Ala Met Asp Ile Phe Gly Glu 
        355                 360                 365             


Leu Arg Cys Cys Pro Ile Glu Leu Tyr Asp Leu Leu Asp Lys Asn Thr 
    370                 375                 380                 


Gly Gln Ser Phe Phe His Asp Glu Val Lys Arg Pro Asn Ser His Thr 
385                 390                 395                 400 


Pro Glu Val Ser Lys Arg Leu Arg Tyr Asp Asp Arg Phe Pro Thr Leu 
                405                 410                 415     


Ala Leu Arg Tyr Ile Asp Glu Thr Glu Leu Phe Lys Arg Ile Arg Phe 
            420                 425                 430         


Gln Ile Gln Leu Gly Ala Phe Arg Tyr Arg Phe Phe Asp Lys Glu Asp 
        435                 440                 445             


Cys Ile Asp Gly Arg Val Arg Val Arg Ser Ile Gln Lys Glu Ile Asn 
    450                 455                 460                 


Gly Tyr Gly Arg Leu Gln Glu Val Ala Asp Lys Arg Leu Glu Lys Trp 
465                 470                 475                 480 


Gly Asp Met Leu Gln Lys Arg Glu Glu Arg Ser Val Lys Leu Glu His 
                485                 490                 495     


Glu Glu Leu Tyr Leu Asp Leu Asp Gln Phe Gln Glu Asp Thr Ala Asn 
            500                 505                 510         


Ser Thr Pro Tyr Val Thr Asp Arg Arg Pro Ser Tyr Asn Ile His Ala 
        515                 520                 525             


Asn Arg Ile Gly Leu Tyr Trp Glu Asp Ser Gln Asn Pro Lys Gln Phe 
    530                 535                 540                 


Lys Val Phe Asp Glu Asn Gly Met Tyr Ile Pro Lys Leu Ile Val Thr 
545                 550                 555                 560 


Glu Asp Glu Lys Ala Pro Ile Asn Met Pro Ala Pro Arg Cys Ala Leu 
                565                 570                 575     


Ser Val Tyr Asp Leu Pro Ala Met Leu Phe Tyr Glu Tyr Leu Arg Glu 
            580                 585                 590         


Gln Gln Lys Gly Asn Val Gln Ala Ala Glu Gln Ile Ile Ile Asp Tyr 
        595                 600                 605             


Glu Asn Asp Tyr Arg Lys Phe Phe Lys Ala Val Ala Glu Gly Thr Leu 
    610                 615                 620                 


Lys Pro Phe Gln Lys Thr Lys Glu Leu Arg Glu Tyr Leu Glu Glu Asn 
625                 630                 635                 640 


Tyr Pro Lys Leu Arg Met Ser Asp Ile Pro Glu Lys Ile Gln Leu Tyr 
                645                 650                 655     


Leu Thr Ser Lys Gly Leu Thr His Asn Asn Lys Pro Glu Thr Val Arg 
            660                 665                 670         


Glu Arg Met Ile Arg Leu Ile Asn Gln His Leu Glu Glu Arg Glu Lys 
        675                 680                 685             


Asn Val Gln Arg Arg Leu Glu His Tyr Gln Glu Asp Arg Lys Met Val 
    690                 695                 700                 


Gly Glu Lys Glu Asn Lys Tyr Gly Lys Lys Gly Phe Ala Asp Val Arg 
705                 710                 715                 720 


His Gly Ala Leu Ala Arg Tyr Leu Thr Gln Ser Met Met Glu Trp Gln 
                725                 730                 735     


Pro Ser Lys Asp Gly Lys Gly Tyr Asp Lys Leu Thr Gly Leu Asn Tyr 
            740                 745                 750         


Asn Val Leu Thr Ala Tyr Leu Ala Thr Phe Gly Thr Pro Gln Thr Val 
        755                 760                 765             


Glu Glu Gly Phe Thr Pro Lys Ser Leu Glu Gln Val Leu Thr Lys Ala 
    770                 775                 780                 


His Ile Ile Gly Gly Ser Asn Pro His Pro Phe Met Asn Lys Val Leu 
785                 790                 795                 800 


Ser Leu Gly Ser Arg Asn Ile Glu Glu Leu Tyr Leu His Tyr Leu Glu 
                805                 810                 815     


Glu Glu Leu Lys His Ile Arg Ser Arg Lys Gln Ser Leu Ser Ser Asn 
            820                 825                 830         


Ser Ser Asp Lys Ala Leu Ser Ser Leu Pro Phe Val His His Asp Arg 
        835                 840                 845             


Met Arg Phe His Glu Arg Thr Asp Glu Glu Met Arg Ala Leu Ala Ala 
    850                 855                 860                 


Arg Tyr Thr Thr Ile Gln Leu Pro Asp Gly Leu Phe Thr Pro Phe Ile 
865                 870                 875                 880 


Val Glu Ile Leu Gln Gln His Tyr Ser Asp Asn Asn Glu Leu Gln Thr 
                885                 890                 895     


Ala Leu Lys Gln Asp Ile Pro Ala Lys Leu Asn Pro Thr His Asn Ala 
            900                 905                 910         


Ala Tyr Leu Ile Thr Gln Phe Tyr Gln Thr Val Leu Lys Asp Asp Ala 
        915                 920                 925             


Gln Pro Phe Tyr Leu Ser Ser Lys Thr Tyr Thr Arg Thr Lys Glu Gly 
    930                 935                 940                 


Glu Asp Pro Lys Thr Phe Ser Phe Lys Lys Thr Tyr Glu Leu Phe Ser 
945                 950                 955                 960 


Val Leu Asn Asn Asp Lys Lys Asp Ser Phe Pro Tyr Glu Leu Ile Pro 
                965                 970                 975     


Leu Phe Leu Thr Ser Asp Glu Ile Gln Glu Arg Leu Ser Ala Lys Leu 
            980                 985                 990         


Leu Asp Glu Asn Gly Asn Pro Ile  Pro Glu Ala Gly Lys  Lys Gly Lys 
        995                 1000                 1005             


Pro Ala  Thr Asp Ser Gln Gly  Asn Val Ile Trp Gln  Arg Ile Ile 
    1010                 1015                 1020             


Lys Gln  Glu Ile Lys Asn His  Val Glu Ser Leu Ser  Asp Lys Asp 
    1025                 1030                 1035             


Leu Lys  Ile Ser Met Asn Gln  Ser Trp Lys Gln Lys  Asn Glu Glu 
    1040                 1045                 1050             


Arg Ala  Ala Lys Arg Glu Ala  Met Gln Ser Arg Leu  Ile Arg Gln 
    1055                 1060                 1065             


Ile Asn  Glu Val Lys Asp Asn  Glu Arg Leu Leu Arg  Arg Tyr Lys 
    1070                 1075                 1080             


Thr Gln  Asp Met Val Leu Phe  Leu Met Ala Lys Lys  Met Phe Ala 
    1085                 1090                 1095             


Asn Ile  Ile Ser Glu Gln Gly  Asn Glu Val Asn Trp  Lys Gln Met 
    1100                 1105                 1110             


Arg Leu  Ser Lys Val Cys Asn  Glu Ala Phe Leu Arg  Gln Thr Leu 
    1115                 1120                 1125             


Thr Phe  Arg Val Pro Val Ala  Val Gly Glu Lys Thr  Val Tyr Val 
    1130                 1135                 1140             


Glu Gln  Glu Asn Met Ser Leu  Lys Asn Tyr Gly Glu  Phe Tyr Arg 
    1145                 1150                 1155             


Phe Leu  Thr Asp Asp Arg Leu  Thr Ser Leu Leu Glu  Asn Ile Val 
    1160                 1165                 1170             


Glu Thr  Leu Lys Pro Asn Lys  Asp Gly Asp Leu Val  Ile Arg His 
    1175                 1180                 1185             


Thr Asp  Leu Met Ser Glu Leu  Ala Ala Tyr Asp Gln  Ile Arg Ser 
    1190                 1195                 1200             


Thr Ile  Phe Glu Leu Ile Gln  Lys Ile Glu Asp Ile  Ile Ile Glu 
    1205                 1210                 1215             


Lys Lys  Lys Asp Leu Lys Asp  Pro Asn Ser Asp Met  Phe Trp Ala 
    1220                 1225                 1230             


His Glu  Gly Leu Pro Lys Leu  Asn Asn Phe Ala Ser  Leu Leu Glu 
    1235                 1240                 1245             


Leu Ile  Asp Arg Leu Asn Asp  Met Ala Leu Thr Asp  Asp Glu Arg 
    1250                 1255                 1260             


Arg Leu  Leu Val Ala Ile Arg  Asn Ala Phe Ser His  Asn Ser Tyr 
    1265                 1270                 1275             


Asn Ile  Asp Phe Ser Leu Ile  Lys Thr Ile Lys His  Leu Pro Glu 
    1280                 1285                 1290             


Val Ala  Lys Gly Ile Leu Gln  His Leu Gln Ser Val  Leu Gly Val 
    1295                 1300                 1305             


Glu Gln  Ile Gln 
    1310         


<210>  2384
<211>  1118
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2384

Met Glu Asp Asp Lys Lys Thr Lys Glu Ser Thr Asn Met Leu Asp Asn 
1               5                   10                  15      


Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val Tyr 
            20                  25                  30          


Ile Thr Ile Asn His Ile Asn Lys Leu Leu Glu Ile Arg Glu Ile Asp 
        35                  40                  45              


Asn Asp Glu Lys Val Leu Asp Ile Lys Ala Leu Trp Gln Lys Gly Asn 
    50                  55                  60                  


Lys Asp Leu Asn Gln Lys Ala Arg Leu Arg Glu Leu Met Thr Lys His 
65                  70                  75                  80  


Phe Pro Phe Leu Glu Thr Ala Ile Tyr Ser Lys Asn Lys Glu Asp Lys 
                85                  90                  95      


Glu Glu Val Lys Gln Glu Lys Gln Ala Thr Ala Gln Ser Phe Lys Ser 
            100                 105                 110         


Leu Glu His Cys Leu Phe Leu Phe Leu Glu Lys Leu Gln Glu Ala Arg 
        115                 120                 125             


Asn Tyr Tyr Ser His Tyr Lys Tyr Ser Glu Ser Thr Lys Glu Pro Met 
    130                 135                 140                 


Leu Glu Lys Glu Leu Leu Lys Lys Met Tyr Asn Ile Phe Asp Asp Asn 
145                 150                 155                 160 


Ile Gln Leu Val Ile Lys Asp Tyr Gln His Asn Lys Asp Ile Asn Pro 
                165                 170                 175     


Asp Glu Asp Phe Lys His Leu Asp Arg Thr Glu Glu Asp Phe Asn Tyr 
            180                 185                 190         


Tyr Phe Thr Arg Asn Lys Lys Gly Asn Ile Thr Ala Ser Gly Leu Leu 
        195                 200                 205             


Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Met Gln 
    210                 215                 220                 


Gln Lys Leu Lys Gly Phe Lys Asp Asn Arg Glu Ser Lys Lys Lys Met 
225                 230                 235                 240 


Thr His Glu Val Phe Cys Arg Ser Arg Met Leu Leu Pro Lys Leu Arg 
                245                 250                 255     


Leu Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu Asn 
            260                 265                 270         


Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Gln Gly Val 
        275                 280                 285             


Asp Arg Glu Lys Phe Lys Val Pro Phe Asp Pro Ala Asp Glu Asp Tyr 
    290                 295                 300                 


Asp Ala Glu Gln Glu Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp 
305                 310                 315                 320 


Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Tyr Asn Glu Ile Phe 
                325                 330                 335     


Thr Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile 
            340                 345                 350         


Tyr Lys Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg His Leu Thr His 
        355                 360                 365             


Lys Leu Tyr Gly Phe Glu Arg Ile Gln Glu Phe Asn Lys Gln Asn Arg 
    370                 375                 380                 


Pro Asp Glu Trp Lys Ala Leu Val Lys Asp Leu Asp Thr Tyr Glu Thr 
385                 390                 395                 400 


Ser Asn Glu Arg Tyr Ile Ser Glu Thr Thr Pro His Tyr His Leu Glu 
                405                 410                 415     


Asn Gln Lys Ile Gly Ile Arg Phe Arg Asn Gly Asn Lys Asp Ile Trp 
            420                 425                 430         


Pro Ser Leu Lys Thr Asn Gly Glu Asn Asn Glu Lys Ser Lys Tyr Lys 
        435                 440                 445             


Leu Asp Lys Gln Tyr Gln Ala Glu Ala Phe Leu Ser Val His Glu Leu 
    450                 455                 460                 


Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Lys Lys Glu Glu Pro Asn 
465                 470                 475                 480 


Asn Asp Lys Lys Asn Ala Ser Ile Val Glu Gly Phe Ile Lys Arg Glu 
                485                 490                 495     


Ile Arg Asp Ile Tyr Lys Leu Tyr Asp Ala Phe Ala Asn Gly Glu Ile 
            500                 505                 510         


Asn Ser Ile Gly Asp Leu Glu Lys Tyr Cys Glu Asp Lys Gly Ile Pro 
        515                 520                 525             


Lys Arg His Leu Pro Lys Gln Ile Val Ala Ile Leu Tyr Asp Glu Pro 
    530                 535                 540                 


Lys Asp Met Val Lys Glu Ala Lys Arg Lys Gln Lys Glu Met Val Lys 
545                 550                 555                 560 


Asp Thr Lys Lys Leu Leu Ala Thr Leu Glu Lys Gln Thr Gln Gly Glu 
                565                 570                 575     


Ile Glu Asp Gly Gly Arg Asn Ile Arg Leu Leu Lys Ser Gly Glu Ile 
            580                 585                 590         


Ala Arg Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln Lys 
        595                 600                 605             


Asp Asn Glu Gly Asn Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu 
    610                 615                 620                 


Tyr Gln Met Leu Gln Arg Ser Leu Ala Leu Tyr Asn Lys Glu Glu Lys 
625                 630                 635                 640 


Pro Thr Arg Tyr Phe Lys Gln Val Asn Leu Ile Glu Ser Gly Asn Pro 
                645                 650                 655     


His Pro Phe Leu Asn Asn Thr Gly Trp Lys Glu Cys Asn Asn Ile Leu 
            660                 665                 670         


Ser Phe Tyr Arg Ser Tyr Leu Thr Lys Lys Ile Glu Phe Leu Asn Glu 
        675                 680                 685             


Leu Lys Pro Glu Asp Trp Glu Lys Asn Gln Tyr Phe Leu Lys Leu Lys 
    690                 695                 700                 


Glu Pro Lys Thr Asn Arg Glu Thr Leu Val Gln Gly Trp Lys Asn Gly 
705                 710                 715                 720 


Phe Asn Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg Glu Trp Phe 
                725                 730                 735     


Lys Arg His Gln Asn Asp Ser Glu Glu Tyr Lys Lys Val Glu Ala Leu 
            740                 745                 750         


Lys Arg Val Gly Leu Val Thr Lys Val Ile Pro Leu Phe Phe Lys Glu 
        755                 760                 765             


Glu Tyr Phe Lys Glu Asp Ala Gln Lys Glu Ile Asn Asn Cys Val Gln 
    770                 775                 780                 


Pro Phe Tyr Ser Leu Pro Tyr Asn Val Gly Asn Ile His Lys Pro Asp 
785                 790                 795                 800 


Glu Glu Asp Phe Leu Leu Ser Glu Glu Arg Lys Lys Leu Trp Gly Asp 
                805                 810                 815     


Lys Lys Tyr Asn Phe Lys Gly Tyr Lys Ala Lys Val Lys Ser Lys Lys 
            820                 825                 830         


Leu Thr Asp Lys Glu Lys Glu Glu Tyr Arg Ser Tyr Leu Glu Phe Gln 
        835                 840                 845             


Ser Trp Asn Lys Phe Glu Arg Glu Leu Arg Leu Val Arg Asn Gln Asp 
    850                 855                 860                 


Ile Val Thr Trp Leu Leu Cys Met Glu Leu Phe Asp Asn Leu Lys Val 
865                 870                 875                 880 


Glu Gly Leu Asn Val Glu Glu Leu Gln Lys Leu Arg Leu Lys Asp Ile 
                885                 890                 895     


Asp Thr Asp Thr Ala Lys Lys Asp Lys Asn Asn Ile Leu Asn Arg Ile 
            900                 905                 910         


Met Pro Met Gln Leu Pro Val Thr Val Tyr Glu Ile Asp Asp Ser His 
        915                 920                 925             


Asn Ile Val Lys Asp Arg Pro Leu His Thr Val Tyr Ile Glu Glu Thr 
    930                 935                 940                 


Lys Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys Asp 
945                 950                 955                 960 


Arg Arg Leu Asn Gly Leu Phe Ser Phe Val Asp Thr Ser Ser Glu Ala 
                965                 970                 975     


Glu Leu Lys Ser Lys Pro Ile Ser Lys Leu Arg Val Glu Tyr Glu Leu 
            980                 985                 990         


Gly Glu Tyr Gln Asn Ala Arg Ile  Glu Ile Ile Glu Asp  Met Leu Ala 
        995                 1000                 1005             


Leu Glu  Gly Ala Leu Ile Glu  Lys Asp Lys Asn Leu  Pro Thr Asp 
    1010                 1015                 1020             


Asn Phe  Ser Asn Met Leu Asn  Gly Trp Leu Lys Gly  Lys Asn Asp 
    1025                 1030                 1035             


Ala Asp  Lys Glu Glu Thr Lys  Lys Ala Ile Asp Phe  Leu Val Ala 
    1040                 1045                 1050             


Val Arg  Asn Ala Phe Ser His  Asn Gln Tyr Pro Met  Arg Asn Arg 
    1055                 1060                 1065             


Ile Ala  Phe Ala Asn Ile Asn  Pro Phe Ser Leu Ser  Ser Ala Asn 
    1070                 1075                 1080             


Thr Ser  Glu Glu Lys Gly Leu  Gly Ile Ala Asn Gln  Leu Lys Asp 
    1085                 1090                 1095             


Lys Thr  His Lys Thr Ile Glu  Lys Ile Ile Lys Ile  Glu Lys Pro 
    1100                 1105                 1110             


Ile Glu  Thr Lys Glu 
    1115             


<210>  2385
<211>  1105
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2385

Met Gln Ser Phe Ile Cys Tyr Lys Asn Gln Ser Ile Thr Tyr Lys Glu 
1               5                   10                  15      


Lys Ile Met Asn Asn Asp Tyr Gln Lys Asn His Val Glu Lys Asp Asn 
            20                  25                  30          


Asn Tyr Leu Trp Gly Thr Phe Leu Asn Gln Ala Arg Leu Asn Ala Tyr 
        35                  40                  45              


Ile Thr Leu Cys His Ile Ser Asp Leu Leu Glu Glu Ser Thr Val Asp 
    50                  55                  60                  


Glu Asp Ser Ile Ala Thr Met Ser Val Leu Asp Phe Leu Asp Ser Asp 
65                  70                  75                  80  


Lys Asp Ile Ile Lys Ser Glu Arg Val Phe Lys Leu Val Glu Lys His 
                85                  90                  95      


Phe Pro Val Leu Lys Ile Ile Tyr Asp Lys Gln Lys Glu Lys Gly Lys 
            100                 105                 110         


Asp Asp Asp Ala Gln Cys Arg Ser Lys Lys Tyr Lys Glu Ile Leu Thr 
        115                 120                 125             


Arg Leu Leu Gln Ala Ile Asn Phe Asn Arg Asn Lys Tyr Cys His Ile 
    130                 135                 140                 


Cys Ser Gly Lys Lys Glu Pro Asn Tyr Asp Val Lys Thr Leu Ile Lys 
145                 150                 155                 160 


His Leu Asp Asn Cys Phe Asp Val Ser Val Asp Lys Ile Lys Asn Arg 
                165                 170                 175     


Leu Ser Leu Phe Glu Asn Asp Lys Arg Asp Asp Asp Pro Lys Asp Glu 
            180                 185                 190         


Val Ile His Leu Arg Arg Phe Lys Gly Ala Glu Lys Glu Asn Gly Lys 
        195                 200                 205             


Lys Lys Ser Lys Ala Asn Pro Lys Phe His Tyr His Phe Asn Asp Asn 
    210                 215                 220                 


Lys Gly Gln Leu Ser Glu Lys Gly Leu Ala Phe Leu Ala Ala Leu Phe 
225                 230                 235                 240 


Leu Ser Lys Lys Asp Ala His Glu Phe Leu Lys Lys Gln His Gly Phe 
                245                 250                 255     


Lys Arg Ser Glu Thr Pro Ala Ala Arg Ala Thr Leu Glu Ser Phe Tyr 
            260                 265                 270         


Cys Tyr Arg Ile Thr Ile Pro Lys Pro Val Ile Ser Ser Asp Val Asp 
        275                 280                 285             


Lys Asn Gly Leu Ala Leu Asp Thr Leu Asn Glu Leu Lys Lys Cys Pro 
    290                 295                 300                 


Lys Glu Ser Phe Glu Leu Leu Ser Lys Glu Arg Gln Lys Glu Phe Arg 
305                 310                 315                 320 


Val Ile Asp Ser Glu Asp Thr Glu Glu Asp Gly Asn Glu Ile Leu Met 
                325                 330                 335     


Arg Arg Tyr Ser Asp Arg Phe Asp Tyr Leu Ser Leu Arg Tyr Cys Asp 
            340                 345                 350         


Glu Asn Glu Val Phe Asp Lys Ile Arg Phe His Ile Asp Leu Gly Arg 
        355                 360                 365             


Tyr Tyr Phe Lys Phe Tyr Pro Lys Gln Thr Ile Asp Gly Asp Met Arg 
    370                 375                 380                 


Gln Arg Ala Leu Asp Lys Arg Leu Lys Thr Phe Gly Arg Ile Lys Glu 
385                 390                 395                 400 


Val Lys Asp Lys Val Asp Leu Glu Trp Gly Asp Leu Ile Lys Ala Pro 
                405                 410                 415     


Gly Glu Lys His Gly Glu Gln Ser Asp Pro Tyr Lys Thr Lys Thr Thr 
            420                 425                 430         


Pro His Tyr His Leu Val Asp Asn Gln Ile Gly Phe Val Leu Gly Asp 
        435                 440                 445             


Arg Asp Leu Pro Asp Ile Lys Gln Pro Glu Gly Lys Ile Ser Leu Lys 
    450                 455                 460                 


Glu Pro Asp Ala Trp Leu Ser Ile Tyr Glu Leu Pro Gly Met Ile Phe 
465                 470                 475                 480 


His Gly Leu Ser Asn Ser Arg Gly Phe Lys Arg Thr Glu Glu Leu Ile 
                485                 490                 495     


Glu Gln His Ile Thr Arg Gln Lys Glu Ile Cys Lys Gln Val Ser Glu 
            500                 505                 510         


Thr Gly Val Ile Pro Glu Asn Ala Gly Lys Phe Leu Pro Lys Ala Leu 
        515                 520                 525             


Arg Asp Ala Ile Ala Gly Lys Ala Lys Gln Ser Asp Tyr Ala Lys Lys 
    530                 535                 540                 


Lys Leu Gln Arg Met Leu Asp Asp Thr Ser His Arg Ile Lys Ala Leu 
545                 550                 555                 560 


Lys Ala Thr Arg Gln Arg Met Ala Asp Pro Gly Asn Lys Pro Gly Lys 
                565                 570                 575     


Lys Lys Phe Phe Asp Leu Arg Ala Gly Lys Leu Ala Asp Phe Leu Ala 
            580                 585                 590         


Arg Asp Ile Met Ala Leu Gln Lys Phe Asp Pro Asn Lys Glu Gly Lys 
        595                 600                 605             


Asp Lys Leu Thr Ser Val Asn Phe Gln Val Leu Gln Ala Thr Leu Ala 
    610                 615                 620                 


Tyr Tyr Gly Ala Lys Lys Asp Thr Ile Glu Asn Ile Phe Arg Thr Ser 
625                 630                 635                 640 


Gly Leu Leu Gly Gly Asp Asn Pro His Pro Phe Leu Asn Gln Ile Lys 
                645                 650                 655     


Pro Thr Arg His Asn Ser Ile Ala Asp Phe Tyr Glu Ala Tyr Leu Asn 
            660                 665                 670         


Ile Lys Glu Lys Tyr Leu Glu Gly Cys Gln Lys Asp Gly Asn Leu Asp 
        675                 680                 685             


Ser Tyr Gln Phe Leu Arg Pro Ser Arg Gln Arg Tyr Ala Lys Thr Ala 
    690                 695                 700                 


Arg Asp Leu Lys Gln Ile Ala Gly Arg Leu Phe Lys Gln Pro Val Asn 
705                 710                 715                 720 


Ile Pro Lys Gly Phe Phe Lys Glu Gln Ile Glu Glu Ile Val Cys Asn 
                725                 730                 735     


Lys Val Pro Ser Pro Glu Gly Arg Glu Met Asn Thr Ala Tyr Met Ile 
            740                 745                 750         


Gln Gly Trp Phe Lys Lys Thr Gln Gly Asn Gln Gln Pro Phe Tyr Gly 
        755                 760                 765             


Tyr Ala Lys Thr Tyr Pro Val Val Ser Lys Ala Lys Glu Tyr Ala Lys 
    770                 775                 780                 


Lys Arg Thr Asn Gln Lys Ile Ala Glu Thr Leu Arg Ser Leu Ser Pro 
785                 790                 795                 800 


Glu Met Ser Tyr Lys Asp Leu Lys Met Ser Ile Glu Glu Asn Ile Pro 
                805                 810                 815     


Glu Asn Gly Arg Tyr Asp Pro Glu Asn Leu Arg Asp Asn Leu Leu Lys 
            820                 825                 830         


Gly Cys Lys Asp Leu Lys Lys Asn Glu Arg Ala Leu Lys Arg Phe Arg 
        835                 840                 845             


Val Gln Asp Ile Ile Met Phe Met Met Val Glu Lys Thr Leu Lys Asp 
    850                 855                 860                 


Gln Leu Ser Ile Glu Gly Lys Phe Leu Gln Leu Glu Ala Ile Thr Pro 
865                 870                 875                 880 


Thr Pro Glu Lys Lys Asp Lys Pro Phe Asn Lys Pro Ile Leu Cys His 
                885                 890                 895     


Thr Asp Ile Lys Ile Pro Phe Asn Thr Asn Pro Asn His His Asp Ala 
            900                 905                 910         


Ser Tyr Val Gly Phe Ile Gln Glu Gln Tyr Lys Asp Leu Tyr Ala Thr 
        915                 920                 925             


Gln Gly Lys Lys Ile Ile Leu Lys Tyr Lys Ile Thr Ser Glu Asn Thr 
    930                 935                 940                 


Lys Leu Lys Asp Ile Gly Lys Tyr Arg Arg Tyr Leu Tyr Asp Arg Arg 
945                 950                 955                 960 


Thr Pro Gly Leu Leu Ile Trp Gln Tyr Pro Pro Asn Ala Gln Ser Asp 
                965                 970                 975     


Val Glu Ile Lys Tyr Ser Glu Ile Glu Arg Gln Ile Met Ala Tyr Asp 
            980                 985                 990         


Gln Asn Arg Leu Lys Ile Ala Glu  Gln Leu Tyr Leu Leu  Glu Lys Leu 
        995                 1000                 1005             


Val Ile  Asp Cys Phe Val Pro  Lys His Glu Leu Gly  Asp Ser His 
    1010                 1015                 1020             


Ile Ser  Phe Asn Ala Val Ala  Glu Lys Leu Gln Thr  Glu Leu Ile 
    1025                 1030                 1035             


Gly Phe  Glu Glu Lys Gly Asn  Val Leu Leu Lys Ile  Arg Asn Ala 
    1040                 1045                 1050             


Leu Gly  His Asn Gln Phe Pro  Val Phe Met Gly Val  Ile Glu Asn 
    1055                 1060                 1065             


Ala Ala  Gly Asp Thr Ile Ala  Glu Lys Met Phe Ser  Ile Thr Glu 
    1070                 1075                 1080             


Ser Tyr  Val Gln Gln Ala Thr  Lys Gln Ile Glu Asp  Gly Asp Arg 
    1085                 1090                 1095             


Asp Lys  Asp Ile Ala Asn Val  
    1100                 1105 


<210>  2386
<211>  1129
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2386

Met Lys Glu Glu Glu Thr Pro Val Val Ser Thr Tyr Asn Lys Asp Asn 
1               5                   10                  15      


Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val Tyr 
            20                  25                  30          


Ile Thr Ile Asn His Ile Asn Lys Leu Leu Glu Ile Arg Glu Ile Asp 
        35                  40                  45              


Asn Asp Glu Lys Val Leu Asp Ile Lys Ala Leu Trp Gln Lys Gly Asn 
    50                  55                  60                  


Lys Asp Leu Asn Gln Lys Ala Arg Leu Arg Glu Leu Met Thr Lys His 
65                  70                  75                  80  


Phe Pro Phe Leu Glu Thr Ala Ile Tyr Thr Lys Asn Lys Glu Asp Lys 
                85                  90                  95      


Lys Glu Val Lys Gln Glu Lys Gln Ala Glu Ala Gln Ser Leu Glu Ser 
            100                 105                 110         


Leu Lys Asp Cys Leu Phe Leu Phe Leu Glu Lys Leu Gln Glu Ala Arg 
        115                 120                 125             


Asn Tyr Tyr Ser His Tyr Lys Tyr Ser Glu Ser Thr Lys Glu Pro Met 
    130                 135                 140                 


Leu Glu Glu Gly Leu Leu Glu Lys Met Tyr Asn Ile Phe Asp Asp Asn 
145                 150                 155                 160 


Ile Gln Leu Val Ile Lys Asp Tyr Gln His Asn Lys Asp Ile Asn Pro 
                165                 170                 175     


Asp Glu Asp Phe Lys His Leu Asp Arg Lys Gly Gln Phe Lys Tyr Ser 
            180                 185                 190         


Phe Ala Asp Asn Glu Gly Asn Ile Thr Glu Ser Gly Leu Leu Phe Phe 
        195                 200                 205             


Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Met Gln Gln Lys 
    210                 215                 220                 


Leu Arg Gly Phe Lys Asp Asn Arg Glu Ser Lys Lys Lys Met Thr His 
225                 230                 235                 240 


Glu Val Phe Cys Arg Ser Arg Met Leu Leu Pro Lys Leu Arg Leu Glu 
                245                 250                 255     


Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu Asn Glu Leu 
            260                 265                 270         


Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Lys Gly Glu Asp Arg 
        275                 280                 285             


Lys Lys Phe Glu Val Pro Phe Asp Ser Thr Asp Glu Asp Tyr Asp Ala 
    290                 295                 300                 


Glu Gln Asp Pro Phe Lys Asn Thr Leu Ile Arg His Gln Asp Arg Phe 
305                 310                 315                 320 


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Tyr Asn Glu Ile Phe Ala Asn 
                325                 330                 335     


Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile Tyr Lys 
            340                 345                 350         


Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg His Leu Thr His Lys Leu 
        355                 360                 365             


Tyr Gly Phe Glu Arg Ile Gln Glu Phe Ala Lys Gln Asn Arg Thr Asp 
    370                 375                 380                 


Glu Trp Lys Ala Leu Val Lys Asp Leu Asp Thr Tyr Glu Thr Ser Asn 
385                 390                 395                 400 


Glu Arg Tyr Ile Ser Glu Thr Thr Pro His Tyr His Leu Glu Asn Gln 
                405                 410                 415     


Lys Ile Gly Ile Arg Asn Lys Lys Lys Lys Lys Lys Lys Asn Ile Trp 
            420                 425                 430         


Pro Ser Leu Glu Thr Asn Thr Thr Val Asn Glu Lys Ser Lys Tyr Asn 
        435                 440                 445             


Leu Gly Lys Ser Phe Lys Ala Lys Ala Phe Leu Ser Val His Glu Leu 
    450                 455                 460                 


Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Thr Lys Glu Glu Pro Asn 
465                 470                 475                 480 


Asn Lys Glu Ile Asn Ala Ser Lys Val Glu Gly Ile Ile Glu Lys Lys 
                485                 490                 495     


Ile Arg Asp Met Tyr Lys Leu Tyr Glu Ala Phe Ala Asn Gly Glu Ile 
            500                 505                 510         


Asn Ser Glu Asp Asp Leu Lys Lys Tyr Cys Lys Gly Lys Asp Ile Glu 
        515                 520                 525             


Met Val His Leu Pro Lys Gln Met Val Ala Ile Leu Lys Asn Lys Pro 
    530                 535                 540                 


Lys Asp Val Ala Glu Glu Ala Lys His Lys Gln Lys Lys Met Val Lys 
545                 550                 555                 560 


Ala Ala Glu Cys Lys Gln Arg Lys Met Val Lys Asp Thr Lys Lys Leu 
                565                 570                 575     


Leu Ala Ala Leu Glu Lys Gln Thr Gln Gly Glu Ile Glu Asp Gly Gly 
            580                 585                 590         


Arg Asn Ile Arg Leu Leu Lys Ser Gly Glu Ile Ala Arg Trp Leu Val 
        595                 600                 605             


Asn Asp Met Met Arg Phe Gln Pro Val Gln Lys Asp Asn Glu Gly Asn 
    610                 615                 620                 


Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln Met Leu Gln 
625                 630                 635                 640 


Arg Ser Leu Ala Leu Tyr Asn Lys Glu Glu Lys Pro Thr Arg Tyr Phe 
                645                 650                 655     


Arg Gln Val Asn Leu Ile Glu Ser Gly Asn Pro His Pro Phe Leu Asn 
            660                 665                 670         


Asn Thr Gly Trp Lys Glu Cys Asn Asn Ile Leu Ser Phe Tyr Arg Ser 
        675                 680                 685             


Tyr Leu Thr Lys Lys Ile Glu Phe Leu Asn Glu Leu Lys Pro Glu Asp 
    690                 695                 700                 


Trp Glu Lys Asn Gln Tyr Phe Leu Lys Leu Lys Glu Pro Lys Thr Asn 
705                 710                 715                 720 


Arg Glu Thr Leu Val Gln Gly Trp Lys Asn Gly Phe Asn Leu Pro Arg 
                725                 730                 735     


Gly Ile Phe Thr Glu Pro Ile Arg Lys Trp Phe Lys Arg His Gln Asn 
            740                 745                 750         


Asp Ser Glu Glu Tyr Asn Lys Val Glu Ala Leu Asp Arg Val Gly Leu 
        755                 760                 765             


Val Thr Lys Val Ile Pro Leu Phe Phe Lys Glu Glu Tyr Phe Lys Asp 
    770                 775                 780                 


Asp Ala Gln Lys Glu Ile Asn Asn Cys Val Gln Pro Phe Tyr Ser Leu 
785                 790                 795                 800 


Pro Tyr Asn Val Gly Asn Ile His Lys Pro Asp Glu Lys Asp Phe Leu 
                805                 810                 815     


His Arg Glu Glu Arg Ile Glu Leu Trp Gly Lys Lys Lys Asp Lys Phe 
            820                 825                 830         


Lys Gly Tyr Lys Ala Pro Lys Lys Pro Lys Lys Ile Thr Asp Glu Val 
        835                 840                 845             


Lys Glu Glu His Arg Ser Tyr Leu Glu Phe Gln Ser Trp Asn Lys Phe 
    850                 855                 860                 


Glu Arg Glu Leu Arg Leu Val Arg Asn Gln Asp Ile Val Thr Trp Leu 
865                 870                 875                 880 


Leu Cys Met Glu Leu Phe Asp Asn Leu Lys Val Glu Gly Leu Asn Val 
                885                 890                 895     


Glu Glu Leu Gln Lys Leu Arg Leu Lys Asp Ile Asp Thr Asp Thr Ala 
            900                 905                 910         


Lys Lys Asp Lys Asn Asn Ile Leu Asn Arg Ile Met Pro Met Gln Leu 
        915                 920                 925             


Pro Val Thr Val Tyr Glu Ile Asp Asp Ser His Asn Ile Val Lys Asp 
    930                 935                 940                 


Lys Pro Leu His Thr Val Tyr Ile Glu Glu Thr Lys Thr Lys Leu Leu 
945                 950                 955                 960 


Lys Gln Gly Asn Phe Lys Ala Leu Val Lys Asp Arg Arg Leu Asn Gly 
                965                 970                 975     


Leu Phe Ser Phe Val Asp Thr Ser Ser Glu Ala Glu Leu Lys Asp Lys 
            980                 985                 990         


Pro Ile Ser Lys Ser Val Val Glu  Tyr Glu Leu Gly Glu  Tyr Gln Asn 
        995                 1000                 1005             


Ala Arg  Ile Glu Thr Ile Lys  Asp Met Leu Leu Leu  Glu Glu Thr 
    1010                 1015                 1020             


Leu Ile  Glu Lys Tyr Lys Thr  Leu Pro Thr Asn Asn  Phe Ser Ala 
    1025                 1030                 1035             


Met Leu  Asn Ala Trp Leu Glu  Gly Lys Asp Glu Ser  Asp Lys Ala 
    1040                 1045                 1050             


Arg Phe  Gln Asn Asp Val Asp  Leu Leu Val Ala Val  Arg Asn Ala 
    1055                 1060                 1065             


Phe Ser  His Asn Gln Tyr Pro  Met Arg Asn Arg Ile  Ala Phe Ala 
    1070                 1075                 1080             


Lys Ile  Asn Pro Phe Ser Leu  Ser Ser Ala Asp Thr  Ser Glu Glu 
    1085                 1090                 1095             


Lys Lys  Leu Asn Ile Ala Asn  Gln Leu Lys Asp Lys  Thr Lys Glu 
    1100                 1105                 1110             


Thr Ile  Glu Lys Ile Ile Lys  Ile Glu Lys Pro Ile  Glu Thr Lys 
    1115                 1120                 1125             


Glu 
    


<210>  2387
<211>  1140
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2387

Met Glu Asn Asp Gln Gln Ile Leu Glu Asn Arg Arg Arg Thr Leu Ala 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Ser Asn His Leu Ala Thr Ser Phe Glu Gln Lys Ala 
        35                  40                  45              


Leu His Glu Glu Gly Gln Ile Pro Ala Ser Phe Leu Cys Asn Lys Ser 
    50                  55                  60                  


Ile Lys Lys Ile Asn Trp Asn His Val Tyr Ser Lys Ala Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Ile Phe Asp Ala Asp Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Arg Glu Thr Ser Asp Lys Glu Gly Lys Asp Phe Thr Ala Met Asn Glu 
            100                 105                 110         


Thr Leu Lys Leu Val Phe Asp Glu Leu Gln Ala Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Ala Asp Ser Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Val Glu Leu Ala Asp Phe Leu Thr Val Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Ala Asp Asp Asp Tyr 
                165                 170                 175     


Ala Val Val Glu Ser Lys Gln Ile Val Thr Pro Asp Asn Gln Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Ile Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Val Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Leu Ala Tyr Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asp Leu Arg Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Glu 
            260                 265                 270         


Val Ile Thr Glu Glu Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Glu Glu Glu Arg 
    290                 295                 300                 


Glu Lys Ile Leu Asp Glu Ile Asp Tyr Glu Asp Tyr Ile Glu Ser Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg His Ser Asn Arg Phe Pro Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Glu Lys Tyr Asn Lys Gln Phe Asp Gly Glu 
        355                 360                 365             


Ala Thr Glu Arg Lys Val Val Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asn Gln Glu Thr Val Glu Leu Lys Ile Asp Ser Ala 
385                 390                 395                 400 


Gln Arg Thr Asn Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Glu Ala Arg Leu Leu 
            420                 425                 430         


Thr Lys Ala Lys Pro Glu Ser Lys Val Ser Tyr Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Lys Ala Glu Glu Met Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Lys Val Asn Asp Ser Gln Leu Met Asn Met Gln Phe Ile Asp Glu 
                485                 490                 495     


Ile Lys Glu Gln Leu Pro Ala Asp Trp Asn Glu Phe Gly Lys Arg Ser 
            500                 505                 510         


Asp Ser Lys Lys Lys Lys Ala Tyr Thr Asn Ala Ala Arg Gln Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Lys Val Leu Ala Asn Tyr Gln Leu 
    530                 535                 540                 


Asn Asp Lys Gln Val Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Val 
545                 550                 555                 560 


Lys Glu Val Asp Asp Ser Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Met Glu Lys His Lys Val 
            580                 585                 590         


Asp Lys Ser Ala Arg Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Thr Asp Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Tyr 
625                 630                 635                 640 


Ala Asp Asn Glu Lys Lys Ala Thr Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Lys Asp Gly His Pro Phe Leu Ala Asn Ile Asn 
            660                 665                 670         


Leu Arg Gln Ile Arg Lys Thr Ser Gln Leu Tyr Glu Leu Tyr Leu Val 
        675                 680                 685             


Glu Lys Ala Asn Lys Gln Val Lys Lys Met Asn Pro Lys Thr Gln Arg 
    690                 695                 700                 


Thr Asn Asn Val Asp Glu Ser Trp Met Met Lys Ser Phe Tyr Ala Lys 
705                 710                 715                 720 


Glu Trp Asn Glu Glu Met Gly Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Thr Asn Ile Pro Phe Thr Ile Arg Gln Trp Glu Glu Lys 
            740                 745                 750         


Glu Lys His Asn Leu Gln Ala Trp Leu His Asn Ile Thr Lys Gly Lys 
        755                 760                 765             


Thr Ser Lys Asp Gly Lys Lys Ala Val Asp Leu Pro Thr Asn Leu Phe 
    770                 775                 780                 


Asp Asp Thr Leu Cys Glu Leu Leu Arg Glu Ala Leu Ile Asn Glu Gly 
785                 790                 795                 800 


Ile Asp Ala Thr Pro Thr Thr Lys Tyr Asn Glu Leu Leu Lys His Trp 
                805                 810                 815     


Trp Thr Ala Arg Glu Asp Ser Thr Gln Asp Phe Tyr Leu Ser Glu Arg 
            820                 825                 830         


Gln Tyr Asp Ile Tyr Asp Glu Lys Val Cys Phe Thr Ile Asn Ser Ser 
        835                 840                 845             


Ala His Phe Ala Asp Tyr Tyr Ala Pro Ala Leu Ser Lys Ala Tyr Ser 
    850                 855                 860                 


Arg Leu Arg Ala Glu Arg Asp Val Ala Arg Arg Thr Asp Lys Arg Leu 
865                 870                 875                 880 


Pro Pro Val Glu Arg Lys Asp Val Glu Arg Val Phe Lys Asn Thr Ile 
                885                 890                 895     


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
            900                 905                 910         


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asn Gln Gln Gln Leu Lys 
        915                 920                 925             


Leu Ser Lys Met Asp Ser Leu Leu Asn Glu Thr Lys Arg Ile Glu Gln 
    930                 935                 940                 


Val Ile Asn Thr Gln Leu Ser Phe Asp Gln Lys Gly Lys Glu Ile Lys 
945                 950                 955                 960 


Asp Lys Thr Asn Leu Glu Ile Val Lys Thr Ile Val Ala Glu Arg Lys 
                965                 970                 975     


Gln Lys Asn Tyr Thr Glu Met Arg Lys Tyr Val His Asp Arg Arg Leu 
            980                 985                 990         


Pro Glu Leu Phe Glu Tyr Ile Asp  Gly Asn Glu Leu Pro  Leu Asp Met 
        995                 1000                 1005             


Leu Leu  Asn Glu Leu Arg Ala  Tyr Asn Thr Ala Lys  Gln Val Val 
    1010                 1015                 1020             


Phe Asp  Thr Val Phe Ala Leu  Glu Lys Lys Ile Ile  Glu Thr Asp 
    1025                 1030                 1035             


Pro Glu  Gly Leu Lys Gln Leu  Asn Val Ser Lys Asp  Gly Gln Ile 
    1040                 1045                 1050             


Gln Thr  Gly Asn Ile Gln His  Lys Pro Tyr Val Gln  Trp Leu Glu 
    1055                 1060                 1065             


Asn Lys  Gly Leu Ile Thr Asp  Lys Asp Lys Gln Phe  Ile Asn Met 
    1070                 1075                 1080             


Val Arg  Asn Ser Phe Ser His  Asn Gln Phe Pro Gln  Arg Ser Thr 
    1085                 1090                 1095             


Val Glu  Leu Leu Met Pro Val  Trp Gln Asn Thr Asn  Ile Ala Leu 
    1100                 1105                 1110             


Gln Ile  Ala Arg Glu Tyr Gln  Gln Leu Ile Val Asp  Ile Ile Glu 
    1115                 1120                 1125             


Lys Ser  Leu His Pro His Lys  Gln His Gln Met Val  
    1130                 1135                 1140 


<210>  2388
<211>  1165
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2388

Met Lys Lys Thr Asn Ala Glu Glu Ser Asn Phe Asn His Thr Leu Asn 
1               5                   10                  15      


Asp Gln Lys Tyr Tyr Phe Ala Gly Tyr Leu Asn Leu Ala Glu Asn Asn 
            20                  25                  30          


Ile Lys Thr Leu Glu Lys Ala Tyr Gly Glu His Phe Leu Cys Ser Gly 
        35                  40                  45              


Lys Glu Thr Ile Ile Ser Asn Leu Asn Asn Thr Ser Ser Leu Ile Asp 
    50                  55                  60                  


Trp Asp Leu Lys Val Lys Phe Leu Ser Gln Tyr Leu Pro Val Val Ser 
65                  70                  75                  80  


Tyr Leu Asn Leu Asp Thr Asp Pro Asn Ser Thr Phe Lys Ile Ile Lys 
                85                  90                  95      


Lys Glu Phe Ser Glu Asn Leu Ser Ser Leu Phe Asp Ser Ile Gly Ser 
            100                 105                 110         


Leu Arg Asn Phe Tyr Ser His Tyr Tyr His Arg Pro Leu Thr Glu Glu 
        115                 120                 125             


Leu Asn Ile Glu Leu Leu Ser Phe Leu Asp Arg Thr Phe Val Ala Val 
    130                 135                 140                 


Cys Ile Asn Val Lys Lys Lys Arg Met Lys Asp Asp Lys Thr Lys Gln 
145                 150                 155                 160 


Leu Leu Lys Ala Thr Leu Asn Asn Glu Leu Asp Leu Leu Leu Lys Ala 
                165                 170                 175     


Lys Lys Glu Glu Leu Leu Lys Lys Lys Lys Glu Gly Lys Lys Val Ser 
            180                 185                 190         


Ile Asp Ala Ile Ser Met Lys Asn Ser Val Leu Asn Asp Ala Phe Asn 
        195                 200                 205             


His Leu Val Gln Leu Asp Lys Asn Ser Arg Glu Glu Ile Pro Gly Arg 
    210                 215                 220                 


Phe Tyr Thr Ser Val Leu Gly Asp Asn Asn Lys Tyr Thr Glu Asn Glu 
225                 230                 235                 240 


Ile Asn Ile Ser Met Ser Gly Leu Leu Phe Leu Leu Ser Met Phe Leu 
                245                 250                 255     


Thr Lys Lys Gln Asn Glu Asp Met Arg Ser Arg Ile Phe Gly Phe Lys 
            260                 265                 270         


Gly Thr Ile Asp Pro Asp Lys Ser Ile Ser Lys Ser Asn Asn Ser Phe 
        275                 280                 285             


Arg Asn Met Ala Thr Asn Trp Val Phe Ser Tyr Leu Ser Phe Lys Gly 
    290                 295                 300                 


Met Lys Lys Gln Leu Gly Asn Thr Phe Lys Lys Glu Ser Leu Leu Val 
305                 310                 315                 320 


Gln Ile Val Asp Glu Leu Ser Lys Val Pro His Glu Val Tyr Gln Thr 
                325                 330                 335     


Leu Ser Pro His His Gln Glu Met Phe Leu Glu Asp Met Asn Glu Tyr 
            340                 345                 350         


Leu Lys Glu Gly Asn Lys Lys Leu Cys Leu Glu Asp Ser Ile Val Val 
        355                 360                 365             


His Pro Val Ile Arg Lys Arg Tyr Glu Asp Lys Phe Asn Tyr Phe Ala 
    370                 375                 380                 


Ile Arg Tyr Leu Asp Glu Phe Val Glu Phe Pro Ser Leu Arg Phe Gln 
385                 390                 395                 400 


Val Asn Val Gly Asn Tyr Val His Asp Arg Arg Met Lys Thr Ile Asp 
                405                 410                 415     


Gly Thr Lys Thr Glu Thr Asp Arg Met Val Lys Glu Glu Ile Arg Ala 
            420                 425                 430         


Phe Gly Lys Leu Ser Val Ile Ser Lys Leu Lys Ala Asp Phe Phe Ala 
        435                 440                 445             


Lys Asp Leu Pro Ser Asp Ile Ser Trp Glu Met Tyr Pro Asn Pro Ser 
    450                 455                 460                 


Tyr Asn Ile Ser Ala Asn Asn Ile Pro Val Tyr Ile Asp Leu Ile Lys 
465                 470                 475                 480 


Ser Ser Val Ala Gly Ala Val Asp Val Gly Lys Asp His Lys Ser Tyr 
                485                 490                 495     


Gln Ala Lys Leu Asp Leu Asp Glu Asp Lys Arg Lys Arg Asn Arg Lys 
            500                 505                 510         


Glu Gly Lys Pro Gly Lys Thr Glu Ile Ala Arg Ile Leu Leu Gly Lys 
        515                 520                 525             


Lys Gln Ile Leu Phe Glu Lys Pro Thr Val Leu Leu Ser Leu Asn Glu 
    530                 535                 540                 


Leu Pro Ala Leu Leu Tyr Glu Val Leu Lys Glu Gly Gly Asp Lys Gln 
545                 550                 555                 560 


Asp Ile Gly Lys Arg Ile Glu Asp Lys Ile Val Glu Lys Ile Val Ala 
                565                 570                 575     


Gln Tyr Lys Leu Ile Asp Gln Tyr Asp Gly Thr Ile Glu Leu Pro Gly 
            580                 585                 590         


Ser Val Ile Pro Lys Lys Leu Arg Lys Ser Gly Ser Glu Lys Cys Thr 
        595                 600                 605             


Asn Met Asp Lys Leu Leu Arg Ala Val Lys Arg Glu Leu Glu Ile Thr 
    610                 615                 620                 


Gln Glu Lys Leu Asp Leu Ile Lys Asn Asn Lys Lys Lys Phe Glu Ser 
625                 630                 635                 640 


Lys Glu Lys Asp Glu Lys Gly Lys Ala Arg Gln His Val Phe Tyr Thr 
                645                 650                 655     


Asn Glu Leu Gly Gln Glu Ala Thr Trp Ile Ala Asn Asp Ile Lys Arg 
            660                 665                 670         


Phe Met Pro Arg Asp Val Lys Glu Lys Trp Arg Gly Tyr His His Ser 
        675                 680                 685             


Asn Leu Gln Lys Leu Leu Ser Gln Tyr Asn Gln Ser Arg Asn Glu Ala 
    690                 695                 700                 


Val Lys Cys Ile Thr Cys Phe Trp Asn Phe Asp Gln Gln Thr Pro Trp 
705                 710                 715                 720 


Gly Lys Gly Ile Lys Glu Ala Phe Tyr Lys Ser Thr Phe Glu Glu Phe 
                725                 730                 735     


Tyr Lys Ala Tyr Leu Asp Asn Arg Met Asp Val Tyr Lys Thr Leu Glu 
            740                 745                 750         


Asn Asn Leu Ile Ala Ala Lys Gly His Ser Lys Leu Phe Asn Lys Glu 
        755                 760                 765             


Lys Lys Lys Ala Phe Val Leu Phe Asp Lys His Leu Tyr Asn Ile Pro 
    770                 775                 780                 


Asp Ile Asn Thr Gln Lys Glu Arg Leu Lys Ser Thr Leu Phe Ile Leu 
785                 790                 795                 800 


Pro Arg Gly Ile Phe Asp Ser Lys Pro Thr Phe Ile Lys Gly Ile Lys 
                805                 810                 815     


Tyr Glu Glu Asp Pro Ser Cys Phe Ala Asp Trp Tyr Gln Phe Ala Asn 
            820                 825                 830         


Asn Ala Gly Asn Glu Tyr Gln Gln Phe Tyr Asn Leu Thr Arg Ser Tyr 
        835                 840                 845             


Thr Ser Leu Phe Glu Glu Thr Lys Lys Asn Asn Glu Gly Leu Lys Glu 
    850                 855                 860                 


Asn Lys Lys Gly Leu Ser Ala Asp Glu Gln Phe Asp Phe Phe Lys Met 
865                 870                 875                 880 


Arg Gln Asp Leu Lys Ile Lys Lys Ile Lys Thr Gln Asp Leu Phe Leu 
                885                 890                 895     


Phe Gln Ile Val Lys Asp Leu Tyr Lys Lys Val Phe Gly Arg Thr Phe 
            900                 905                 910         


Pro Glu Gly Leu Glu Leu Lys Asp Met Tyr Gln Thr Pro Ala Glu Arg 
        915                 920                 925             


Gln Ala Asn Tyr Glu Leu Ala Val Lys Gln Ser Gln Arg Thr Glu Gly 
    930                 935                 940                 


Asp Lys Ser Asp Asn Leu Tyr Asn Thr Asn Phe Leu Trp Asn Leu Thr 
945                 950                 955                 960 


Val Pro Phe Glu Thr Gly Lys Ile Lys Glu Pro Gln Val Lys Leu Lys 
                965                 970                 975     


Asp Ile Gly Lys Phe Tyr Lys Phe Ala Ala Asp Glu Lys Val Gln Thr 
            980                 985                 990         


Ile Leu Ser Tyr Ser Asp Arg Glu  Trp Ser Lys Leu Asp  Leu Glu Lys 
        995                 1000                 1005             


Glu Leu  Glu Leu Met Pro Thr  Ser Tyr Glu Val Ile  Arg Arg Glu 
    1010                 1015                 1020             


Gln Leu  Leu Arg Asp Ile Gln  Gln Phe Glu Lys Arg  Ile Leu Glu 
    1025                 1030                 1035             


Asn Tyr  Pro Ser Asp Gly Asn  Ala His Pro Arg Asp  Phe Glu Ile 
    1040                 1045                 1050             


Val Arg  Asn Gly Ile Leu Ser  Pro Ser Phe Asn Phe  Tyr Leu Leu 
    1055                 1060                 1065             


Lys Gly  Val Ile Ile Lys Asn  Asn Leu Ala Ser Glu  Glu Glu Cys 
    1070                 1075                 1080             


Gln Trp  Phe Glu Gln Val His  Leu Asn Lys Thr Gln  Phe Tyr Pro 
    1085                 1090                 1095             


Glu Val  Ala Thr Lys Ser Thr  Ile Ile Gln Ser Ala  Tyr Leu Leu 
    1100                 1105                 1110             


Leu Leu  Ile Arg Asn Lys Met  Leu His Asn Gln Leu  Pro Ser Lys 
    1115                 1120                 1125             


Gln Asn  Phe Glu Phe Met Thr  Thr Leu Tyr Pro Phe  Gln Gly Tyr 
    1130                 1135                 1140             


Glu Asn  Tyr Ser Thr Tyr Leu  Leu Ser Val Thr Lys  Gln Thr Ile 
    1145                 1150                 1155             


Glu Cys  Leu Ser Ser Ala Met  
    1160                 1165 


<210>  2389
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2389

Met Asn Thr His Gln Glu Glu Leu Gln Ser Trp Ile Thr Arg Lys Arg 
1               5                   10                  15      


Leu Pro Asp Thr Glu Met Lys Lys Tyr Trp Ala Ala Tyr Met Asn Leu 
            20                  25                  30          


Ala Arg Leu Asn Phe Phe Lys Thr Leu Met Phe Ile Ser Asn Ser Ile 
        35                  40                  45              


Gly Asp Leu Lys Pro Ala Lys Asp Asn Asn Gly Lys Gly Asn Thr Glu 
    50                  55                  60                  


Val Asn Met His Asn Met Gly Ile Leu Thr Ala Leu Leu Gly Pro Glu 
65                  70                  75                  80  


Asp Glu Glu Lys Ala Arg Leu Leu Ile Phe Lys His Phe Pro Phe Leu 
                85                  90                  95      


Arg Thr Phe Cys Ile Glu Lys Glu Leu Ser Leu Ser Lys Gln Arg Thr 
            100                 105                 110         


Ile Leu Ile Asp Met Ala Cys Ile Ile Gly Arg Tyr Arg Asn Met Tyr 
        115                 120                 125             


Ser His Ser Ile Phe Ile Ser Asp Asp Asn Glu Lys Val Leu Glu Ser 
    130                 135                 140                 


Glu Lys Arg Cys Ser Glu Tyr Leu Gln Ser Ile Leu Thr Val Ser Thr 
145                 150                 155                 160 


Arg Ile Ile Lys Glu Arg Tyr Arg Ser Asn Lys Asn Asp Ala Gln Arg 
                165                 170                 175     


Gly Met Ile Asp Asp Lys Ser Leu Lys Phe Ile Ser Glu Asn Lys Val 
            180                 185                 190         


Lys Phe Val Tyr Asp Glu Asn Gly Lys Arg Ile Thr Ala Pro Asn Lys 
        195                 200                 205             


Lys Tyr Tyr Leu Ser Thr Ile Asp Lys Asp Asn Thr His Leu Ser Tyr 
    210                 215                 220                 


Phe Gly Lys Leu Met Leu Thr Cys Ile Leu Leu Glu Lys Lys Tyr Ala 
225                 230                 235                 240 


Thr Asp Phe Leu Thr Gln Cys His Phe Leu Asp Ala Phe Asn Asp Ser 
                245                 250                 255     


Glu Val Ala Pro Lys Leu Ser Glu Arg Arg Leu Met Leu Glu Val Met 
            260                 265                 270         


Thr Ala Leu Arg Ile Arg Leu Ala Glu Lys Lys Leu Ser Asn Glu Lys 
        275                 280                 285             


Ser Glu Val Gln Ile Ser Leu Asp Ile Leu Asn Glu Leu Lys Lys Cys 
    290                 295                 300                 


Pro Phe Glu Leu Tyr Glu Leu Leu Gly Ser Glu Asp Lys Arg Leu Phe 
305                 310                 315                 320 


Thr Ile Val Ala Asp Thr Gly Glu Thr Ile Leu Leu Arg Arg His Glu 
                325                 330                 335     


Asp Arg Phe Pro Gln Leu Ala Leu Ser Trp Ile Asp Ser Ser Lys Ala 
            340                 345                 350         


Phe Asp His Leu Arg Phe Gln Val Asn Ala Gly Lys Leu Arg Tyr Leu 
        355                 360                 365             


Phe Arg Asp Asn Lys His Cys Ile Asp Gly Gln Thr Arg Met Arg Val 
    370                 375                 380                 


Leu Glu Glu Pro Leu Asn Gly Tyr Arg Arg Leu Met Glu Phe Glu Glu 
385                 390                 395                 400 


Glu Arg Ile Gln Lys Gln Ser Gly Glu Ile Arg Ser Leu Trp Pro Gly 
                405                 410                 415     


Leu Asp Ile Leu Asn Lys Asp Glu Thr Pro Arg Asn Asp Ala Ser Val 
            420                 425                 430         


Leu Pro Tyr Ile Ser Asp Tyr Arg Val Arg Tyr Leu Phe Asp Gly Asp 
        435                 440                 445             


Asn Ile Gly Ile Ser Ile Gly Asp Phe Thr Pro Ser Ile Thr Lys Thr 
    450                 455                 460                 


Asp Glu Thr Lys Tyr Arg Val Thr Arg Lys Thr Ala Asp Cys Cys Leu 
465                 470                 475                 480 


Ser Lys Tyr Glu Leu Leu Gly Leu Leu Phe Tyr His Leu Leu Thr Leu 
                485                 490                 495     


Arg His Gly Asp Asn Lys Arg Ser Thr Lys Asn Ala Glu Asp Ile Ile 
            500                 505                 510         


Ile Asp Ala Ile Lys Arg Tyr Lys Arg Leu Phe Ser Asp Val Lys Glu 
        515                 520                 525             


Gly Ile Leu Lys Pro Ile Lys Glu Glu Asn Ala Asn Gln Leu Gly Asn 
    530                 535                 540                 


Arg Ile Trp Asn Ser Tyr Gly Ile Asn Ile Lys Asp Ile Pro Asp Lys 
545                 550                 555                 560 


Ile Ile Asp Tyr Leu Leu Val Arg Glu Cys Asn Glu Asp Glu Lys Phe 
                565                 570                 575     


Thr Ala Trp Lys Asn Gly Phe Ile Ser Glu Met Leu Gln Ser Thr Lys 
            580                 585                 590         


Asn Arg Ile Lys Arg Phe Glu Lys Asp Ser Glu Ala Val Ile Ser Ser 
        595                 600                 605             


Asp Asn Lys Pro Gly Lys Lys Asn His Val Ser Leu Lys Pro Gly Ala 
    610                 615                 620                 


Tyr Ala Ser Phe Ile Ala Asn Asp Ile Val Phe Phe Gln Glu Cys Gly 
625                 630                 635                 640 


Ala Thr Glu Lys Met Thr Gly Leu Asn Phe Lys Val Met Gln Ser Arg 
                645                 650                 655     


Leu Ala Thr Phe Thr Lys Asp Gly Ser Thr Ser Phe Asn Ile Leu Leu 
            660                 665                 670         


Gln Thr Leu Lys Asn Ala His Leu Val Ser Thr Thr Tyr Gly Lys Gly 
        675                 680                 685             


Asp His Pro Phe Leu Tyr Arg Val Ile Lys Gln Gln Pro Ser Asp Ile 
    690                 695                 700                 


Val Gln Phe Tyr Lys Ile Tyr Leu Asn Glu Lys Val Leu Tyr Leu Gln 
705                 710                 715                 720 


Ser Asp Ile Pro Asp Asn Ala Ile Phe Leu His Gly Glu Arg Lys Arg 
                725                 730                 735     


Trp Glu Asn Arg Asn Glu Gln Tyr Tyr Arg Asp Leu Ala Glu Arg Tyr 
            740                 745                 750         


Leu Gln Arg Pro Ile Gln Leu Pro Arg Gln Leu Phe Glu Ser His Ile 
        755                 760                 765             


Arg Gln Leu Leu Leu Ser Asp Cys Ile Lys Gly Glu Arg Gly Asn Asp 
    770                 775                 780                 


Leu Lys Glu Ala Ile Asn Ser Ala Ala Ser Gln Gly Arg Cys Asn Thr 
785                 790                 795                 800 


Thr Tyr Met Ile Met Glu Tyr Phe Ala Asp Tyr Leu Cys Asp Gly Thr 
                805                 810                 815     


Gln Phe Phe Tyr Gly Leu Phe Asp Gly Asp Leu Ser His Glu Tyr Asn 
            820                 825                 830         


Tyr Arg Phe Tyr Ser Leu Ile Ser Asn Asn Ile Glu Asn Ser Lys Lys 
        835                 840                 845             


Leu Val Leu Thr Leu Lys Lys Gly Asn Asn Ser Lys Glu Ser Pro Phe 
    850                 855                 860                 


Ile Ser Ala Leu Glu Arg Gly Ile His Trp Ser Lys Met Asn Pro Leu 
865                 870                 875                 880 


Met Lys Lys Gly Leu Lys Asn Asp Ser Ser Glu Gly Asp Phe Val His 
                885                 890                 895     


Ala Ala Lys Arg Ala Tyr Lys Glu Met Thr Glu Thr Glu Arg Met Phe 
            900                 905                 910         


Arg Arg Tyr Ala Val Gln Asp Glu Val Leu Phe Leu Ala Ala Lys Ile 
        915                 920                 925             


Thr Ile Arg Arg Ala Leu Gly Leu Ser Glu Gln Tyr Asn Cys Leu Leu 
    930                 935                 940                 


Gly Asp Ile Lys Pro Gln Gly Gly Ser Leu Leu Glu Gln Thr Ile Pro 
945                 950                 955                 960 


Ser Ile Thr Thr Lys His Thr Ile Asn Thr Gly Asn Lys Lys Gln Lys 
                965                 970                 975     


Pro Lys Gln Val Gln Ile Leu Gln Lys Asn Val Lys Leu Lys Asp Phe 
            980                 985                 990         


Gly Lys Val Phe Lys Leu Leu Asn  Asp Arg Arg Ile Phe  Asp Leu Leu 
        995                 1000                 1005             


Phe Asn  Lys Gly Asn Glu Ala  Val Ser Met Thr Asp  Leu Cys Glu 
    1010                 1015                 1020             


Glu Leu  Glu Arg Tyr Asp Arg  His Arg Val Asp Val  Phe Asp Ser 
    1025                 1030                 1035             


Val Leu  Lys Tyr Glu Ser Lys  Ile Thr Lys Gly Tyr  Thr Asn Lys 
    1040                 1045                 1050             


Glu Leu  Met Asn Glu Ser Gly  Gln Ile Asp Phe Lys  Ala Ile Gln 
    1055                 1060                 1065             


Ala Phe  Asp Lys Gln Asn Thr  Thr Ala Asp Lys Glu  Asp Leu Arg 
    1070                 1075                 1080             


Leu Ile  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Gln Tyr Asn 
    1085                 1090                 1095             


Asn Glu  Pro Ile Leu Phe Asp  Lys Asp Ile Pro Glu  Ile Ala Asp 
    1100                 1105                 1110             


Glu Ile  Ser Ile Ile Ala Lys  Asp Ile Glu Glu Asn  Thr Lys 
    1115                 1120                 1125         


<210>  2390
<211>  1082
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2390

Met Ser Ile Val Asp Tyr Glu Lys Asn Ile Ser Ile Leu Asn Gly Tyr 
1               5                   10                  15      


Leu Pro Ile Ile Asp Phe Leu Asp Asp Glu Leu Glu Asn Asn Leu Asn 
            20                  25                  30          


Thr Arg Val Lys Asn Phe Lys Lys Ser Phe Ile Ile Leu Ala Glu Ala 
        35                  40                  45              


Leu Glu Thr Leu Arg Asn Tyr Tyr Thr His Phe Tyr His Asp Pro Ile 
    50                  55                  60                  


Thr Phe Gly Asp Asn Lys Glu Pro Leu Leu Glu Leu Leu Asp Glu Val 
65                  70                  75                  80  


Leu Leu Lys Thr Ile Leu Asp Val Lys Lys Lys Tyr Leu Lys Thr Asp 
                85                  90                  95      


Lys Thr Lys Glu Ile Leu Lys Asp Ser Leu Arg Glu Glu Met Asp Leu 
            100                 105                 110         


Leu Val Ile Arg Lys Thr Asp Glu Leu Arg Glu Lys Lys Lys Thr Asn 
        115                 120                 125             


Pro Lys Phe Lys Phe Ser Thr Asp Pro Thr Gln Ile Arg Asn Ser Ile 
    130                 135                 140                 


Phe Asn Asp Ala Phe Gln Gly Leu Leu Tyr Glu Asp Lys Glu Asn Asn 
145                 150                 155                 160 


Gly Lys Thr Gln Val Ser Tyr Arg Ala Lys Thr Lys Leu Asn Pro Lys 
                165                 170                 175     


Asp Ile His Lys Gln Glu Glu Arg Asp Phe Glu Ile Pro Leu Ser Thr 
            180                 185                 190         


Ser Gly Ile Val Phe Leu Met Ser Leu Phe Leu Ser Lys Lys Glu Ile 
        195                 200                 205             


Glu Asp Phe Lys Ser Asn Ile Lys Gly Phe Lys Gly Lys Val Val Lys 
    210                 215                 220                 


Asp Glu Asn His Asn Ser Leu Lys Tyr Met Ala Thr His Arg Val Tyr 
225                 230                 235                 240 


Ser Ile Leu Ala Phe Lys Gly Leu Lys Tyr Arg Ile Lys Thr Asp Thr 
                245                 250                 255     


Phe Ser Lys Val Thr Leu Met Met Gln Met Ile Asp Glu Leu Ser Lys 
            260                 265                 270         


Val Pro Asp Cys Val Tyr Gln Asn Leu Ser Glu Thr Lys Gln Lys Asp 
        275                 280                 285             


Phe Ile Glu Asp Trp Asn Glu Tyr Leu Lys Asp Asn Glu Glu Asn Thr 
    290                 295                 300                 


Glu Asn Leu Glu Asn Ser Arg Val Val His Pro Leu Ile Arg Lys Arg 
305                 310                 315                 320 


Tyr Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe 
                325                 330                 335     


Ala Asn Phe Lys Thr Leu Lys Phe Gln Val Phe Met Gly Tyr Tyr Ile 
            340                 345                 350         


His Asp Gln Arg Thr Lys Thr Ile Gly Thr Thr Asn Ile Thr Thr Glu 
        355                 360                 365             


Arg Thr Val Lys Glu Lys Ile Asn Val Phe Gly Lys Leu Ser Lys Met 
    370                 375                 380                 


Asp Asn Leu Lys Lys His Phe Phe Ser Gln Leu Ser Asp Glu Glu Asn 
385                 390                 395                 400 


Thr Asp Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Phe Leu Thr Gln 
                405                 410                 415     


Ala Asp Asn Ser Pro Ala Asn Asn Ile Pro Ile Tyr Leu Glu Leu Lys 
            420                 425                 430         


Asn Gln Gln Ile Ile Lys Glu Lys Asp Asp Ile Lys Ala Glu Val Asn 
        435                 440                 445             


Asn Ser Gln Asn Arg Asn Pro Asn Lys Pro Ser Lys Arg Asp Leu Leu 
    450                 455                 460                 


Asn Lys Ile Ser Asn Thr Asn Glu Asp Phe Tyr Gln Gly Asp Pro Thr 
465                 470                 475                 480 


Ala Ile Leu Ser Leu Asn Glu Ile Pro Ala Leu Leu His Leu Phe Leu 
                485                 490                 495     


Val Gln Pro Asp Asn Lys Thr Gly Gln Gln Ile Glu Asn Ile Ile Arg 
            500                 505                 510         


Ile Lys Ile Glu Lys Gln Phe Asn Ser Ile Lys Asn Pro Ser Lys Asp 
        515                 520                 525             


Asp Lys Gly Val Pro Lys Ser Leu Phe Ala Asp Thr Asn Val Arg Val 
    530                 535                 540                 


Asn Ala Ile Lys Leu Lys Lys Asp Leu Gly Glu Glu Leu Asp Met Leu 
545                 550                 555                 560 


Asn Lys Lys Gln Ile Val Phe Lys Glu Asn Gln Lys Ala Ser Ser Asn 
                565                 570                 575     


Tyr Asp Glu Leu Leu Lys Lys His Gln Phe Thr Pro Lys Asn Lys Arg 
            580                 585                 590         


Pro Ala Leu Arg Lys Tyr Val Phe Tyr Asn Ser Glu Lys Gly Glu Glu 
        595                 600                 605             


Ala Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Lys Gly Phe 
    610                 615                 620                 


Lys Thr Lys Trp Lys Gly Tyr Gln His Ser Glu Leu Gln Arg Lys Leu 
625                 630                 635                 640 


Ala Phe Tyr Asp Arg His Thr Lys Gln Asp Ile Lys Glu Leu Leu Ser 
                645                 650                 655     


Gly Cys Glu Phe Asp His Phe Leu Leu Asp Ile Asn Ala Cys Phe Lys 
            660                 665                 670         


Glu Asp Asp Phe Glu Asp Phe Phe Ser Lys Tyr Leu Lys Asn Arg Ile 
        675                 680                 685             


Glu Thr Leu Asn Ile Ile Leu Lys Gln Leu His Asp Phe Lys Asn Glu 
    690                 695                 700                 


Pro Thr Pro Leu Lys Gly Val Phe Lys Asn Cys Leu Lys Phe Leu Lys 
705                 710                 715                 720 


Gln Lys Asn Tyr Val Thr Glu Asn Pro Glu Ile Ile Lys Lys Arg Ile 
                725                 730                 735     


Leu Ala Lys Pro Ala Phe Leu Pro Arg Gly Ile Phe Asp Glu Arg Pro 
            740                 745                 750         


Thr Met Lys Lys Gly Lys Asn Pro Leu Ile Asp Arg Asp Glu Phe Ala 
        755                 760                 765             


Lys Trp Phe Val Glu Tyr Leu Glu Asn Lys Asp Tyr Gln Lys Phe Tyr 
    770                 775                 780                 


Asn Ser Glu Glu Tyr Arg Ile Arg Asp Ala Asp Phe Lys Lys Asn Ala 
785                 790                 795                 800 


Val Ile Lys Lys Gln Lys Leu Lys Asp Phe Tyr Thr Leu Gln Met Val 
                805                 810                 815     


Asn Tyr Leu Leu Lys Glu Val Phe Gly Lys Asp Glu Met Asn Leu Gln 
            820                 825                 830         


Leu Ser Glu Leu Phe Gln Thr Arg Gln Glu Arg Leu Lys Leu Gln Gly 
        835                 840                 845             


Ile Ala Lys Lys Gln Met Asn Lys Glu Thr Gly Asp Ser Ser Glu Asn 
    850                 855                 860                 


Thr Arg Asn Gln Thr Tyr Ile Trp Asn Lys Asp Val Pro Val Ser Phe 
865                 870                 875                 880 


Phe Asn Gly Lys Val Thr Ile Asp Lys Val Lys Leu Lys Asn Ile Gly 
                885                 890                 895     


Lys Tyr Lys Arg Tyr Glu Arg Asp Glu Arg Val Lys Thr Phe Ile Gly 
            900                 905                 910         


Tyr Glu Val Asp Glu Lys Trp Met Met Tyr Leu Pro His Asn Trp Lys 
        915                 920                 925             


Asp Arg Tyr Ser Val Lys Pro Ile Asn Val Ile Asp Leu Gln Ile Gln 
    930                 935                 940                 


Glu Tyr Glu Glu Ile Arg Ser His Glu Leu Leu Lys Glu Ile Gln Asn 
945                 950                 955                 960 


Leu Glu Gln Tyr Ile Tyr Asp His Thr Thr Asp Lys Asn Thr Leu Leu 
                965                 970                 975     


Gln Asp Gly Asn Pro Asn Phe Lys Met Tyr Val Leu Asn Gly Leu Leu 
            980                 985                 990         


Thr Gly Ile Lys Gln Val Asn Ile  Ala Asp Phe Ile Val  Leu Lys Gln 
        995                 1000                 1005             


Asn Thr  Asn Phe Asp Lys Ile  Asp Phe Thr Gly Ile  Ala Ser Cys 
    1010                 1015                 1020             


Ser Glu  Leu Glu Lys Lys Thr  Ile Ile Leu Ile Ala  Ile Arg Asn 
    1025                 1030                 1035             


Lys Phe  Ala His Asn Gln Leu  Pro Asn Lys Thr Ile  Tyr Asp Leu 
    1040                 1045                 1050             


Ala Asn  Glu Phe Leu Lys Lys  Glu Lys Arg Glu Thr  Tyr Ala Asn 
    1055                 1060                 1065             


Tyr Tyr  Leu Lys Val Leu Lys  Lys Met Ile Ser Asp  Leu Ala 
    1070                 1075                 1080         


<210>  2391
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2391

Met Glu Asn Leu Ser Lys Glu Gln Ile Val Glu Thr Gln Glu Gln Asn 
1               5                   10                  15      


Lys Arg Thr Trp Gly Asn Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn 
            20                  25                  30          


Met Ala Arg Leu Asn Ile Tyr Asn Val Ser Asn His Leu Ala Glu Lys 
        35                  40                  45              


Phe Gly Ile Thr Ala Ile Glu Asn Glu Glu Gln Ile Ser Asn Ser Phe 
    50                  55                  60                  


Leu Gly Asp Lys Glu Asn Lys Val Phe Lys Asn Lys Gln Asn His Ile 
65                  70                  75                  80  


Phe Ser Asn Leu Ile Arg Tyr Leu Pro Ile Val Lys Val Phe Asp Phe 
                85                  90                  95      


Glu Lys Leu Pro Glu Glu Glu Lys Ile Ser Leu Lys Asp Asn Phe Gly 
            100                 105                 110         


Lys Asp Phe Lys Glu Leu Ser Asp Thr Leu Lys Ile Ile Phe Ser Glu 
        115                 120                 125             


Ile Asn Glu Phe Arg Asn Asp Tyr Ser His Tyr Phe Ser Thr Glu Lys 
    130                 135                 140                 


Lys Asn Lys Arg Lys Thr Lys Val Ser Asp Lys Leu Lys Asp Phe Leu 
145                 150                 155                 160 


Asn Ile Asn Tyr Thr Arg Ala Ile Gln Tyr Thr Lys Asn Arg Phe Ile 
                165                 170                 175     


Asn Val Phe Ser Asp Asn Asp Phe Cys Leu Ala Glu Glu Ala Lys Leu 
            180                 185                 190         


Val Glu Asn Asp Asn Thr Ile Thr Gln Asp Gly Ile Val Phe Phe Thr 
        195                 200                 205             


Ser Met Phe Leu Asp Arg Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile 
    210                 215                 220                 


Lys Gly Leu Lys Gly Thr Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu 
225                 230                 235                 240 


Val Leu Met Ala Phe Cys Ile Asn Leu Pro His Asp Lys Phe Val Ser 
                245                 250                 255     


Glu Asn Thr Glu Gln Ala Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn 
            260                 265                 270         


Lys Cys Pro Lys Thr Leu Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln 
        275                 280                 285             


His Phe Leu Pro Lys Leu Glu Asp Glu Gln Ile Asp Asn Val Leu Glu 
    290                 295                 300                 


Asn Ser Val Pro Tyr Thr Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn 
305                 310                 315                 320 


Ile Thr Lys Lys Val Arg Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu 
                325                 330                 335     


Lys Phe Ile Asp Gln Lys Glu Leu Phe Lys Asn Trp Lys Phe Gln Ile 
            340                 345                 350         


Asp Leu Gly Lys Val Val Leu Asp Glu Tyr Thr Lys Thr Leu Gln Gly 
        355                 360                 365             


Lys Asp Glu Thr Arg Thr Val Val Glu Asn Ala Lys Ala Phe Gly Lys 
    370                 375                 380                 


Leu Gln His Leu Asn Asp Glu Glu Asn Val Leu Asn Lys Ile Asn Lys 
385                 390                 395                 400 


Ser Glu Ser Lys Thr His Phe Glu Gln Phe Ala Pro His Tyr Asn Phe 
                405                 410                 415     


Asp Asn Asn Lys Ile Gly Ile Ser Arg Lys Glu Asp Ser Ala Ile Phe 
            420                 425                 430         


Ile Ser Arg Asn Thr Asp Lys Lys Val Lys Phe Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Glu Ala Phe Leu Ser Ile His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Glu Asn Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Glu Ile Asn Asn Ser Lys Ile Leu Asn Lys Lys Phe Ile Glu Ser 
                485                 490                 495     


Ile Lys Ser Lys Leu Thr Asp Phe Asn Thr Phe Asn Lys Arg Ser Gln 
            500                 505                 510         


Gly Arg Lys Glu Lys Ser Ala Tyr Lys Lys Glu Ala Leu Lys Tyr Leu 
        515                 520                 525             


Leu Asp Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu Tyr Asn Leu 
    530                 535                 540                 


Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp Leu Asn Val 
545                 550                 555                 560 


Ala Asp Val Gln Glu Lys Thr Ala Ile Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Asp Arg Ile Lys Ala Met Lys Lys Gly Lys Ala 
            580                 585                 590         


Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp Ile Val Asp 
        595                 600                 605             


Met Ile Ile Gly Glu Glu Lys Lys Lys Lys Ile Thr Ser Phe Tyr Tyr 
    610                 615                 620                 


Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Lys Glu Lys Lys 
625                 630                 635                 640 


Glu Leu Phe Ile His Ile Cys Asn Asn Glu Leu Lys Leu Asn Glu Ser 
                645                 650                 655     


Asp Gly His Pro Phe Leu Lys Asn Ile Ile Leu Tyr Asp Tyr Arg Tyr 
            660                 665                 670         


Thr Ser Asp Leu Tyr Arg Arg Tyr Leu Glu Glu Lys Ala Asp Asn Arg 
        675                 680                 685             


Asn Asn Leu Asn Lys Asn Asp Thr Ser Trp Leu Ala Lys Asn Phe Tyr 
    690                 695                 700                 


Phe Ile Glu Lys Val Glu Val Phe Asp Lys Arg Leu Asn Arg Met Glu 
705                 710                 715                 720 


Phe Lys Pro Gln Thr Val Val Lys Ile Lys Asp Lys Ser Lys Ile Pro 
                725                 730                 735     


Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser Phe Asp Thr Trp 
            740                 745                 750         


Phe Glu Asn Ile Thr Lys Gly Lys Glu Thr Thr Asp Lys Lys Lys Pro 
        755                 760                 765             


Val Asp Leu Pro Thr Asn Leu Phe Asp Asn Tyr Leu Lys Glu Leu Leu 
    770                 775                 780                 


Ile Lys Asp Leu Ser Lys Asn Asn Ile Lys Phe Asn Pro Lys Thr Asn 
785                 790                 795                 800 


Tyr Asn Glu Leu Phe Lys Leu Trp Trp Lys Glu Cys Arg Lys Asp Lys 
                805                 810                 815     


Thr Gln Ser Phe Tyr Asn Ala Glu Arg Glu Tyr Ser Phe Glu Asp Lys 
            820                 825                 830         


Lys Leu Asn Phe Lys Ile Asn Thr Lys Ser Lys Phe Glu Asp Tyr Ile 
        835                 840                 845             


Asn Pro Glu Phe Ala Glu Lys Val Phe Lys Leu Lys Ser Ser Arg Arg 
    850                 855                 860                 


Glu Lys Glu Asn Ser Thr Gly Arg Lys Leu Pro Pro Leu Met Ile Lys 
865                 870                 875                 880 


Asp Leu Glu Lys Ser Met Ala Asn Lys Ile Gly Ser Ile Glu Lys Asp 
                885                 890                 895     


Ile Arg Ile Leu Gln Glu Asp Asp Cys Met Met Leu Leu Met Phe Glu 
            900                 905                 910         


Lys Leu Val Asp Asn Asn Leu Glu Leu Lys Leu Glu Asn Val Asp Thr 
        915                 920                 925             


Leu Met Asn Glu Ser Ile Glu Ile Lys Gln Ser Ile Leu Gly Lys Leu 
    930                 935                 940                 


Ser Phe Asp Asp Phe Gly Asp Asn Val Asn Lys Asn Asp Arg Ile Ile 
945                 950                 955                 960 


Ile Ser Lys Asn Ile Thr Glu Thr Arg Lys Arg Lys Glu Tyr Ser Val 
                965                 970                 975     


Leu Lys Lys Tyr Ile Phe Asp Arg Arg Leu Pro Glu Leu Phe Glu Tyr 
            980                 985                 990         


Phe Glu Thr Glu Asp Ile Thr Met  Glu Lys Ile Lys Leu  Glu Leu Gly 
        995                 1000                 1005             


Thr Tyr  Asn Lys Ala Lys Asp  Ile Val Phe Asp Leu  Ile Phe Asp 
    1010                 1015                 1020             


Leu Glu  Ser Ala Ile Ile Lys  Lys Asn Glu Asn Arg  Ile Lys Glu 
    1025                 1030                 1035             


Leu Asn  Lys Asp Lys Asn Gly  Asn Ile Gln Thr Gly  Asn Ile Gln 
    1040                 1045                 1050             


His Lys  Pro Tyr Leu Phe Trp  Leu Leu Glu Lys Asn  Leu Ile Thr 
    1055                 1060                 1065             


Glu Gln  Glu Phe Thr Phe Leu  Asn Met Val Arg Asn  Thr Phe Ser 
    1070                 1075                 1080             


His Asn  Gln Phe Pro Gln Lys  Lys Thr Met Glu Leu  Phe Ile Lys 
    1085                 1090                 1095             


Asn Trp  Asn Lys Asn Glu Tyr  Ala Lys Gln Ile Leu  Thr Val Tyr 
    1100                 1105                 1110             


Thr Glu  Lys Ile Asn Asn Leu  Ile Glu Lys Val Ile  Asp Ile 
    1115                 1120                 1125         


<210>  2392
<211>  1152
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2392

Met Glu Ile Asp Glu Asn Val Lys Ala Thr Asn Tyr Leu His Thr Leu 
1               5                   10                  15      


Asn Glu Asp Lys His Tyr Phe Gly Gly Tyr Leu Asn Leu Ala Glu Asn 
            20                  25                  30          


Asn Ile Gln Leu Val Phe Lys Leu Phe Arg Lys Arg Phe Asp Cys Gly 
        35                  40                  45              


Asn Ala Lys Leu Glu Phe Ile Ile Lys Glu Ser Phe Asn Asp Lys Ile 
    50                  55                  60                  


Ala Ile Thr Asp Tyr Gln Arg Arg Val Asp Phe Leu Lys Gln Tyr Phe 
65                  70                  75                  80  


Pro Val Val Val Tyr Ile Asp Leu Pro Pro Thr Asn Pro Leu Phe Asn 
                85                  90                  95      


Lys Ile Lys Asn Gln Asp Lys Glu Cys Lys Arg Arg Asp Tyr Phe Arg 
            100                 105                 110         


Thr Ser Phe Thr Cys Leu Ile Lys Ala Val Lys Tyr Leu Arg Asn Phe 
        115                 120                 125             


Tyr Thr His Tyr Tyr His Glu Pro Ile Cys Phe Asp Glu Ser Phe Tyr 
    130                 135                 140                 


Glu Leu Leu Asp Arg Leu Leu Leu Ser Val Ile Asn Asp Val Lys Lys 
145                 150                 155                 160 


His Lys Leu Lys Val Asp Gln Thr Arg His Leu Leu Lys Lys Asp Leu 
                165                 170                 175     


Asn Asp Glu Leu Lys Gln Leu Ile Glu Gln Lys Thr Ala Phe Leu Val 
            180                 185                 190         


Glu Lys Lys Lys Arg Gly Lys Glu Val Asp Leu Ser Pro Glu Ala Ile 
        195                 200                 205             


Glu Asn Ser Val Leu Asn Asp Ala Phe Ser His Phe Leu Asp Gly Asp 
    210                 215                 220                 


Asn Leu Cys Ser Tyr Tyr Gln Ser Lys Cys Asn Arg Gly Gln Asp Ile 
225                 230                 235                 240 


Glu Asn His Val Val Ile Ser Glu Cys Gly Leu Leu Phe Leu Leu Ser 
                245                 250                 255     


Met Phe Leu Tyr Arg Asn Glu Asn Glu Thr Leu Arg Ala Asn Ile Lys 
            260                 265                 270         


Gly Tyr Lys Ala Lys Ile Val Lys Asp Glu Thr Lys Pro Ile Asp Arg 
        275                 280                 285             


Lys Asn Asn Ser Leu Lys Tyr Met Ala Thr His Trp Thr Phe Asn Tyr 
    290                 295                 300                 


Leu Ser Ala Lys Lys Val Lys Lys Arg Leu Asn Thr Thr Phe Leu Lys 
305                 310                 315                 320 


Glu Thr Leu Ile Leu Gln Ile Ala Asp Glu Leu Ser Lys Val Pro Asp 
                325                 330                 335     


Glu Leu Tyr Gln Thr Tyr Thr Glu Asp Thr Lys Asn Lys Phe Ile Val 
            340                 345                 350         


Asp Val Asn Glu Tyr Phe Lys Asp Asn Glu Glu Leu Arg Ser Phe Asp 
        355                 360                 365             


Asn Met Met Val Ser His Pro Val Ile Arg Lys Arg Tyr Glu Asp Lys 
    370                 375                 380                 


Phe Asn Tyr Phe Val Leu Arg Tyr Leu Asp Glu Phe Ile Asp Phe Pro 
385                 390                 395                 400 


Ser Leu Arg Phe Gln Val His Leu Gly Asn Tyr Val His Asp Arg Arg 
                405                 410                 415     


Glu Lys Asn Met Gln Ser Val His Val Lys Thr Asp Arg Ile Ile Lys 
            420                 425                 430         


Glu Lys Ile Asn Ala Phe Gly Arg Leu Ser Glu Leu Thr Asp Ile Lys 
        435                 440                 445             


Thr Gly Phe Phe Ser Asn Leu Lys Glu Asp Thr Lys Trp Glu Leu Phe 
    450                 455                 460                 


Pro Asn Pro Ser Tyr Asn Phe Val Gly Asn Asn Ile Pro Ile Tyr Ile 
465                 470                 475                 480 


Asn Leu Glu Arg Cys Lys Val Lys Lys Pro Ser Glu Asn Ile Ser Ser 
                485                 490                 495     


Asn Glu Ser Lys Ile Arg Lys Arg Ile Asp Gly Lys Leu Thr Lys Asp 
            500                 505                 510         


Gln Ile Val His Lys Leu Gly Arg Asp Ile Ile Trp Gly Lys Pro Thr 
        515                 520                 525             


Ala Leu Leu Ser Leu Asn Glu Leu Pro Ala Leu Leu Tyr Lys Val Lys 
    530                 535                 540                 


Gln Glu Ile Glu Asn Glu Lys Ser Arg Ile Glu Ile Gly Lys Lys Ile 
545                 550                 555                 560 


Glu Asn Leu Leu Leu Asn Thr Ile Ile Lys Lys Tyr Gln Ala Ile Asp 
                565                 570                 575     


Lys Phe Glu Thr Gly Asp Lys Val Pro Val Ser Lys Ile Thr Lys Arg 
            580                 585                 590         


Leu Arg Arg Ala Lys Asp Val Glu Asp Ile Gln Met Gly Lys Leu Arg 
        595                 600                 605             


Asn Asp Ile Glu Lys Glu Ile Asp Ile Cys Asn Val Lys Leu Lys Leu 
    610                 615                 620                 


Ile Ala Thr Asn Arg Arg Glu Leu Ser Leu Lys His Gly Ile Asn Glu 
625                 630                 635                 640 


Lys Gln Gly Lys Phe Ile Phe Thr Ser Lys Glu Leu Gly Cys Glu Ala 
                645                 650                 655     


Ala Trp Leu Ala Asp Asp Leu Lys Arg Phe Met Pro Lys Gly Thr Lys 
            660                 665                 670         


Phe Asn Trp Lys Gly Tyr Gln His Ser Gln Leu Gln Gln Ser Leu Ala 
        675                 680                 685             


Phe Tyr Asp Leu Arg Pro Asn Glu Ala Tyr Asn Phe Leu Lys Glu Tyr 
    690                 695                 700                 


Trp Asp Phe Asp Asp Glu Asn Tyr Phe Ile Asn Leu Trp Ile Arg Lys 
705                 710                 715                 720 


Ala Phe Arg Ser Asn Lys Phe Asp Glu Phe Tyr Glu Lys Tyr Leu Asn 
                725                 730                 735     


Asn Arg Lys Leu Phe Phe Glu Asn Ile Ser Asn Gln Ile Gly Gly Leu 
            740                 745                 750         


Ser Lys Lys Leu Val Asn Lys Phe Ile Glu Gln Gln Tyr Leu Trp Asn 
        755                 760                 765             


Ile Phe Tyr Lys Arg Leu Tyr Leu Ile Pro Ser Thr Glu Lys Gln Lys 
    770                 775                 780                 


Glu Glu Leu Leu Asn Gln Pro Ile Val Phe Ser Arg Gly Ile Phe Asp 
785                 790                 795                 800 


Glu Lys Pro Ser Tyr Ile Lys Gly Lys Ser Leu Glu Glu Ser Pro Glu 
                805                 810                 815     


Leu Tyr Ala Asp Trp Tyr Arg Phe Ile Gln Asp Asp Asn His Gln Leu 
            820                 825                 830         


Gln Lys Phe Tyr Tyr Trp Glu Arg Asp Tyr Lys Glu Leu Phe Glu Val 
        835                 840                 845             


His Arg Asn Ser Glu Tyr Met Glu Glu Asn Lys Tyr Glu Leu Ser Pro 
    850                 855                 860                 


Lys Gln Gln Phe Glu Leu Phe Thr Arg Lys Trp Asn Lys Lys Ile Lys 
865                 870                 875                 880 


Lys Val Ala Gly Gln Asp Leu Phe Leu His Leu Ile Leu Lys Asp Val 
                885                 890                 895     


Leu Lys Glu Leu Phe Ala Gln Glu Ile Pro Leu Gln Leu Lys Asn Phe 
            900                 905                 910         


Tyr Leu Thr Gln Glu Glu Arg Ala Ala Met Gln Ile Glu Ala Asp Arg 
        915                 920                 925             


Met Asn Lys Arg Gly Glu Gly Asp Lys Ser Pro Asn Phe Val Asn Glu 
    930                 935                 940                 


Asp Phe Ile Trp Asn Met Lys Val Pro Phe Lys Ser Lys Gln Ile Asn 
945                 950                 955                 960 


Asp Pro Ala Val Lys Ile Lys Asp Leu Gly Lys Phe Val Arg Phe Leu 
                965                 970                 975     


Glu Asp Glu Lys Val Gln Arg Ile Phe Asp Tyr Asp Gly Glu Lys Glu 
            980                 985                 990         


Trp Thr Lys Glu Ala Leu Glu Met  Glu Leu Glu Ser Tyr  Glu Lys Val 
        995                 1000                 1005             


Arg Arg  Phe Arg Ile Phe Lys  Thr Leu Gln Glu Leu  Glu Arg Arg 
    1010                 1015                 1020             


Ile Leu  Gln Lys Arg Gly Gly  Asn Gly Val Glu Tyr  Pro Glu Glu 
    1025                 1030                 1035             


Leu Leu  Asn Gly Arg Asn Pro  Asn Phe Lys Lys Cys  Met Val Thr 
    1040                 1045                 1050             


Gly Leu  Leu Lys Tyr His Thr  Asp Val Ser Ile Lys  Asp Leu Asp 
    1055                 1060                 1065             


Trp Leu  Ser Glu Leu Ser Lys  Asn Ala Phe Glu Ser  Ser Glu Thr 
    1070                 1075                 1080             


Phe Glu  Leu Leu Lys Thr Lys  Ser Gln Ile Val Gln  Asp Ser Phe 
    1085                 1090                 1095             


Ile Leu  Ile Tyr Ile Arg Asn  Lys Phe Ser His Asn  Gln Leu Pro 
    1100                 1105                 1110             


Val Lys  Gln Tyr Leu Glu Met  Ile Tyr Asn Cys Asn  Tyr Tyr Trp 
    1115                 1120                 1125             


Ser Thr  Tyr Ala Glu Gly Ile  Ala Lys Phe Val Glu  Glu Leu Thr 
    1130                 1135                 1140             


Asn Lys  Phe Ile Asn Ile Leu  Asp Ser 
    1145                 1150         


<210>  2393
<211>  1146
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2393

Met Glu Ser Ile Ile Gly Leu Gly Leu Ser Phe Asn Pro Tyr Lys Thr 
1               5                   10                  15      


Ala Asp Lys His Tyr Phe Gly Ser Phe Leu Asn Leu Ala Asp Asn Asn 
            20                  25                  30          


Leu Lys Ala Val Phe Ala Glu Phe Lys Glu Arg Ile Ser Asp Lys Ser 
        35                  40                  45              


Lys Asp Glu Asp Ile Ser Asn Leu Ile Glu Lys His Phe Ile Asp Asn 
    50                  55                  60                  


Met Ser Ile Val Asp Tyr Glu Lys Asn Ile Ser Ile Leu Asn Gly Tyr 
65                  70                  75                  80  


Leu Pro Ile Ile Asp Phe Leu Asp Asp Glu Leu Glu Asn Asn Leu Asn 
                85                  90                  95      


Thr Arg Val Lys Asn Phe Lys Lys Ser Phe Ile Ile Leu Ala Glu Ala 
            100                 105                 110         


Leu Glu Thr Leu Arg Asn Tyr Tyr Thr His Phe Tyr His Asp Pro Ile 
        115                 120                 125             


Thr Phe Gly Asp Asn Lys Glu Pro Leu Leu Glu Leu Leu Asp Glu Val 
    130                 135                 140                 


Leu Leu Lys Thr Ile Leu Asp Val Lys Lys Lys Tyr Leu Lys Thr Asp 
145                 150                 155                 160 


Lys Thr Lys Glu Ile Leu Lys Asp Ser Leu Arg Glu Glu Met Asp Leu 
                165                 170                 175     


Leu Val Ile Arg Lys Thr Asp Glu Leu Arg Glu Lys Lys Lys Thr Asn 
            180                 185                 190         


Pro Lys Phe Lys Phe Ser Thr Asp Pro Thr Gln Ile Arg Asn Ser Ile 
        195                 200                 205             


Phe Asn Asp Ala Phe Gln Gly Leu Leu Tyr Glu Asp Lys Glu Asn Asn 
    210                 215                 220                 


Gly Lys Thr Gln Val Ser Tyr Arg Ala Lys Thr Lys Leu Asn Pro Lys 
225                 230                 235                 240 


Asp Ile His Lys Gln Glu Glu Arg Asp Phe Glu Ile Pro Leu Ser Thr 
                245                 250                 255     


Ser Gly Ile Val Phe Leu Met Ser Leu Phe Leu Ser Lys Lys Glu Ile 
            260                 265                 270         


Glu Asp Phe Lys Ser Asn Ile Lys Gly Phe Lys Gly Lys Val Val Lys 
        275                 280                 285             


Asp Glu Asn His Asn Ser Leu Lys Tyr Met Ala Thr His Arg Val Tyr 
    290                 295                 300                 


Ser Ile Leu Ala Phe Lys Gly Leu Lys Tyr Arg Ile Lys Thr Asp Thr 
305                 310                 315                 320 


Phe Ser Lys Val Thr Leu Met Met Gln Met Ile Asp Glu Leu Ser Lys 
                325                 330                 335     


Val Pro Asp Cys Val Tyr Gln Asn Leu Ser Glu Thr Lys Gln Lys Asp 
            340                 345                 350         


Phe Ile Glu Asp Trp Asn Glu Tyr Leu Lys Asp Asn Glu Glu Asn Thr 
        355                 360                 365             


Glu Asn Leu Glu Asn Ser Arg Val Val His Pro Leu Ile Arg Lys Arg 
    370                 375                 380                 


Tyr Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe 
385                 390                 395                 400 


Ala Asn Phe Lys Thr Leu Lys Phe Gln Val Phe Met Gly Tyr Tyr Ile 
                405                 410                 415     


His Asp Gln Arg Thr Lys Thr Ile Gly Thr Thr Asn Ile Thr Thr Glu 
            420                 425                 430         


Arg Thr Val Lys Glu Lys Ile Asn Val Phe Gly Lys Leu Ser Lys Met 
        435                 440                 445             


Asp Asn Leu Lys Lys His Phe Phe Ser Gln Leu Ser Asp Glu Glu Asn 
    450                 455                 460                 


Thr Asp Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Phe Leu Thr Gln 
465                 470                 475                 480 


Ala Asp Asn Ser Pro Ala Asn Asn Ile Pro Ile Tyr Leu Glu Leu Lys 
                485                 490                 495     


Asn Gln Gln Ile Ile Lys Glu Lys Asp Asp Ile Lys Ala Glu Val Asn 
            500                 505                 510         


Asn Ser Gln Asn Arg Asn Pro Asn Lys Pro Ser Lys Arg Asp Leu Leu 
        515                 520                 525             


Asn Lys Ile Ser Asn Thr Asn Glu Asp Phe Tyr Gln Gly Asp Pro Thr 
    530                 535                 540                 


Ala Ile Leu Ser Leu Asn Glu Ile Pro Ala Leu Leu His Leu Phe Leu 
545                 550                 555                 560 


Val Gln Pro Asp Asn Lys Thr Gly Gln Gln Ile Glu Asn Ile Ile Arg 
                565                 570                 575     


Ile Lys Ile Glu Lys Gln Phe Asn Ser Ile Lys Asn Pro Ser Lys Asp 
            580                 585                 590         


Asp Lys Gly Val Pro Lys Ser Leu Phe Ala Asp Thr Asn Val Arg Val 
        595                 600                 605             


Asn Ala Ile Lys Leu Lys Lys Asp Leu Gly Glu Glu Leu Asp Met Leu 
    610                 615                 620                 


Asn Lys Lys Gln Ile Val Phe Lys Glu Asn Gln Lys Ala Ser Ser Asn 
625                 630                 635                 640 


Tyr Asp Glu Leu Leu Lys Lys His Gln Phe Thr Pro Lys Asn Lys Arg 
                645                 650                 655     


Pro Ala Leu Arg Lys Tyr Val Phe Tyr Asn Ser Glu Lys Gly Glu Glu 
            660                 665                 670         


Ala Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Lys Gly Phe 
        675                 680                 685             


Lys Thr Lys Trp Lys Gly Tyr Gln His Ser Glu Leu Gln Arg Lys Leu 
    690                 695                 700                 


Ala Phe Tyr Asp Arg His Thr Lys Gln Asp Ile Lys Glu Leu Leu Ser 
705                 710                 715                 720 


Gly Cys Glu Phe Asp His Phe Leu Leu Asp Ile Asn Ala Cys Phe Lys 
                725                 730                 735     


Glu Asp Asp Phe Glu Asp Phe Phe Ser Lys Tyr Leu Lys Asn Arg Ile 
            740                 745                 750         


Glu Thr Leu Asn Ile Ile Leu Lys Gln Leu His Asp Phe Lys Asn Glu 
        755                 760                 765             


Pro Thr Pro Leu Lys Gly Val Phe Lys Asn Cys Leu Lys Phe Leu Lys 
    770                 775                 780                 


Gln Lys Asn Tyr Val Thr Glu Asn Pro Glu Ile Ile Lys Lys Arg Ile 
785                 790                 795                 800 


Leu Ala Lys Pro Ala Phe Leu Pro Arg Gly Ile Phe Asp Glu Arg Pro 
                805                 810                 815     


Thr Met Lys Lys Gly Lys Asn Pro Leu Ile Asp Arg Asp Glu Phe Ala 
            820                 825                 830         


Lys Trp Phe Val Glu Tyr Leu Glu Asn Lys Asp Tyr Gln Lys Phe Tyr 
        835                 840                 845             


Asn Ser Glu Glu Tyr Arg Ile Arg Asp Ala Asp Phe Lys Lys Asn Ala 
    850                 855                 860                 


Val Ile Lys Lys Gln Lys Leu Lys Asp Phe Tyr Thr Leu Gln Met Val 
865                 870                 875                 880 


Asn Tyr Leu Leu Lys Glu Val Phe Gly Lys Asp Glu Met Asn Leu Gln 
                885                 890                 895     


Leu Ser Glu Leu Phe Gln Thr Arg Gln Glu Arg Leu Lys Leu Gln Gly 
            900                 905                 910         


Ile Ala Lys Lys Gln Met Asn Lys Glu Thr Gly Asp Ser Ser Glu Asn 
        915                 920                 925             


Thr Arg Asn Gln Thr Tyr Ile Trp Asn Lys Asp Val Pro Val Ser Phe 
    930                 935                 940                 


Phe Asn Gly Lys Val Thr Ile Asp Lys Val Lys Leu Lys Asn Ile Gly 
945                 950                 955                 960 


Lys Tyr Lys Arg Tyr Glu Arg Asp Glu Arg Val Lys Thr Phe Ile Gly 
                965                 970                 975     


Tyr Glu Val Asp Glu Lys Trp Met Met Tyr Leu Pro His Asn Trp Lys 
            980                 985                 990         


Asp Arg Tyr Ser Val Lys Pro Ile  Asn Val Ile Asp Leu  Gln Ile Gln 
        995                 1000                 1005             


Glu Tyr  Glu Glu Ile Arg Ser  His Glu Leu Leu Lys  Glu Ile Gln 
    1010                 1015                 1020             


Asn Leu  Glu Gln Tyr Ile Tyr  Asp His Thr Thr Asp  Lys Asn Thr 
    1025                 1030                 1035             


Leu Leu  Gln Asp Gly Asn Pro  Asn Phe Lys Met Tyr  Val Leu Asn 
    1040                 1045                 1050             


Gly Leu  Leu Thr Gly Ile Lys  Gln Val Asn Ile Ala  Asp Phe Ile 
    1055                 1060                 1065             


Val Leu  Lys Gln Asn Thr Asn  Phe Asp Lys Ile Asp  Phe Thr Gly 
    1070                 1075                 1080             


Ile Ala  Ser Cys Ser Glu Leu  Glu Lys Lys Thr Ile  Ile Leu Ile 
    1085                 1090                 1095             


Ala Ile  Arg Asn Lys Phe Ala  His Asn Gln Leu Pro  Asn Lys Thr 
    1100                 1105                 1110             


Ile Tyr  Asp Leu Ala Asn Glu  Phe Leu Lys Lys Glu  Lys Arg Glu 
    1115                 1120                 1125             


Thr Tyr  Ala Asn Tyr Tyr Leu  Lys Val Leu Lys Lys  Met Ile Ser 
    1130                 1135                 1140             


Asp Leu  Ala 
    1145     


<210>  2394
<211>  1116
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2394

Met Glu Asn Thr Ile Glu Ile Gln Lys Gln Ser Ile Arg Thr Leu Asn 
1               5                   10                  15      


Asn Ala Pro Gln Tyr Phe Gly Leu Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn Tyr Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Glu Glu Glu Lys Ile Thr Ile Ser Phe Leu Gly Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Lys Gln Ser Tyr Ile Tyr Phe Asn Leu Ile 
65                  70                  75                  80  


Lys Tyr Met Pro Val Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Lys 
                85                  90                  95      


Asn Glu Ile Asp Lys Thr Lys Asn Asn Ser Gly Lys Asp Phe Asn Lys 
            100                 105                 110         


Leu Ser Asp Thr Leu Lys Val Ile Phe Lys Glu Leu Asn Glu Phe Arg 
        115                 120                 125             


Asn Asp Tyr Ser His Tyr Phe Ser Thr Glu Lys Gln Asp Lys Arg Lys 
    130                 135                 140                 


Leu Lys Ile Ser Ser Glu Leu Lys Asp Phe Leu Asn Ile Asn Phe Ser 
145                 150                 155                 160 


Arg Ala Leu Ser Tyr Thr Lys Asn Arg Leu Lys Asp Val Phe Ser Asp 
                165                 170                 175     


Asp Asp Phe Asn Ile Ala Ser Gln Thr Val Val Val Asn Asn Asp Asn 
            180                 185                 190         


Thr Ile Thr Gln Asp Gly Ile Val Phe Leu Ile Ser Met Phe Leu Asp 
        195                 200                 205             


Met Glu Asn Ala Phe Gln Phe Ile Asn Lys Ile Ile Gly Leu Lys Gly 
    210                 215                 220                 


Thr Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Val Leu Met Thr Phe 
225                 230                 235                 240 


Cys Val Lys Leu Pro His Asp Lys Phe Val Ser Glu Asn Pro Gln Gln 
                245                 250                 255     


Thr Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Leu 
            260                 265                 270         


Leu Tyr Asn Val Ile Thr Glu Glu Glu Lys Gln Ile Phe Lys Pro Gln 
        275                 280                 285             


Ile Gln Thr Glu Gln Ile Glu Asn Ile Ile Ser Asn Ser Val Pro Asp 
    290                 295                 300                 


Thr Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Ser Ile Thr Lys Lys Val 
305                 310                 315                 320 


Arg Tyr Glu Asn Arg Phe Ser Tyr Phe Ala Leu Lys Tyr Ile Asp Leu 
                325                 330                 335     


Lys Glu Leu Phe Lys Lys Trp Arg Phe Gln Ile Asp Leu Gly Lys Val 
            340                 345                 350         


Val Leu Asp Lys Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Val Arg 
        355                 360                 365             


Thr Val Thr Glu Asn Ala Lys Ala Phe Gly Arg Leu Gln Asp Phe Tyr 
    370                 375                 380                 


Asp Gln Glu Lys Ile Leu Asn Lys Ile Asn Ile Gly Glu Asn Lys Thr 
385                 390                 395                 400 


Arg Phe Tyr Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn 
                405                 410                 415     


Lys Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Ser Lys 
            420                 425                 430         


Asn Thr Thr His Lys Val Lys Phe Asn Leu Leu Gln Pro Leu Pro Glu 
        435                 440                 445             


Val Phe Leu Ser Ile His Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr 
    450                 455                 460                 


Leu Glu Gln Gly Lys Thr Glu Lys Leu Ile Asn Asn Phe Ile Lys Leu 
465                 470                 475                 480 


Ser Asn Ser Thr Ile Leu Asn Lys Lys Phe Ile Glu Thr Ile Lys Tyr 
                485                 490                 495     


Lys Leu Ser Asp Leu Asp Val Phe His Lys Arg Ser Met Gly Arg Lys 
            500                 505                 510         


Glu Ile Ser Ala Tyr Arg Lys Asp Ile Leu Lys Tyr Leu Ile Ala Arg 
        515                 520                 525             


Lys Glu Lys Leu Asn Gln Ile Leu Ser Glu His Asn Leu Ser Val Lys 
    530                 535                 540                 


Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp Leu Asn Ile Ala Asp Val 
545                 550                 555                 560 


Gln Glu Lys Thr Ala Ile Ser Asp Arg Ile Lys Leu Met Lys Arg Asp 
                565                 570                 575     


Cys Met Asp Arg Leu Lys Ala Ile Lys Lys Asn Asn Ala Pro Lys Ile 
            580                 585                 590         


Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile Val Asp Met Leu Ile 
        595                 600                 605             


Ser Glu Gly Lys Lys Lys Lys Ile Thr Ser Phe Tyr Tyr Asp Lys Met 
    610                 615                 620                 


Gln Glu Cys Leu Val Leu Phe Ala Asp Lys Glu Lys Lys Glu Leu Phe 
625                 630                 635                 640 


Ile Ser Ile Cys Ser Glu Leu Lys Leu Asn Asp Ala Asp Gly His Pro 
                645                 650                 655     


Phe Leu Lys Asn Ile Asn Leu Ser Asp Ile Arg Tyr Thr Ser Asp Leu 
            660                 665                 670         


Tyr Lys Ile Tyr Leu Gln Glu Lys Ala Asp Asn Arg Asn Gln Arg Asn 
        675                 680                 685             


Arg Thr Asp Thr Ser Trp Leu Ala Lys Asn Phe Tyr Thr Leu Lys Asn 
    690                 695                 700                 


Val Glu Val Phe Asp Lys Lys Gln Gln Arg Lys Ile Phe Lys Leu Gln 
705                 710                 715                 720 


Thr Ile Val Glu Leu Pro Gln Asp Lys Ser Lys Ile Pro Phe Thr Ile 
                725                 730                 735     


Arg Gln Leu Glu Lys Glu Lys Ser Ser Phe Asn Lys Trp Leu Glu Tyr 
            740                 745                 750         


Ile Thr Lys Gly Lys Glu Thr Thr Asp Lys Lys Lys Pro Val Asn Leu 
        755                 760                 765             


Pro Ala Asn Leu Phe Asp Asp Thr Leu Lys Lys Leu Leu Lys Thr Glu 
    770                 775                 780                 


Leu Ser Lys Asn Asn Ile Gln Tyr Asn Lys Glu Ala Asn Tyr Asn Gln 
785                 790                 795                 800 


Leu Phe Lys Ile Trp Trp Lys Glu Phe Arg Lys Asp Asn Thr Gln Asn 
                805                 810                 815     


Phe Tyr Thr Ala Glu Arg Glu Tyr Thr Phe Glu Glu Glu Lys Leu Asn 
            820                 825                 830         


Phe Lys Ile Asn Thr Gln Pro Lys Phe Glu Asn Tyr Tyr Thr Arg Phe 
        835                 840                 845             


Ala Glu Asn Val Phe Asn Lys Lys Gln Ala Leu Arg Asn Glu Glu Arg 
    850                 855                 860                 


Lys Thr Lys Arg Asn Leu Pro Pro Ile Gln Lys Ile His Val Ile Lys 
865                 870                 875                 880 


Lys Ile Arg Asn Lys Ile Gly Asn Thr Glu Lys Glu Ile Arg Met Leu 
                885                 890                 895     


Gln Glu Glu Asp Arg Leu Met Leu Leu Met Phe Glu Lys Leu Thr Lys 
            900                 905                 910         


Glu Asn Leu Asn Leu Lys Leu Glu Lys Val Asn Glu Leu Leu Asn Glu 
        915                 920                 925             


Arg Ile Glu Ile Lys Glu Lys Ile Pro Gly Lys Leu Ser Phe Asp Asp 
    930                 935                 940                 


Leu Gly Glu Lys Thr Ile Thr Arg Asn Ile Val Glu Thr Arg Lys Arg 
945                 950                 955                 960 


Lys Glu Tyr Ser Val Leu Gln Lys Tyr Ile Phe Asp Arg Arg Leu Pro 
                965                 970                 975     


Glu Leu Phe Glu Tyr Phe Asn Glu Thr Asp Ile Leu Ile Glu Lys Ile 
            980                 985                 990         


Lys Thr Glu Leu Asp Ala Tyr Asn  Lys Ala Lys Asp Ile  Val Phe Asp 
        995                 1000                 1005             


Leu Ile  Phe Lys Leu Glu Glu  Ala Ile Ile Lys Lys  Asp Glu Thr 
    1010                 1015                 1020             


Gly Ile  Lys Glu Leu Asn Lys  Asp Gln Asn Gly Asn  Ile Gln Thr 
    1025                 1030                 1035             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu His Trp Leu  Leu Lys Lys 
    1040                 1045                 1050             


Asn Met  Ile Thr Glu Lys Glu  Phe Thr Phe Ile Asn  Met Val Arg 
    1055                 1060                 1065             


Asn Thr  Phe Ser His Asn Arg  Phe Pro Gln Lys Lys  Thr Met Glu 
    1070                 1075                 1080             


Leu Phe  Ile Lys Lys Trp Asn  Asp Asn Asn Phe Ala  Tyr Gln Ile 
    1085                 1090                 1095             


Leu Glu  Thr Tyr Lys Gln Lys  Thr Asn Asn Ile Ile  Glu Lys Leu 
    1100                 1105                 1110             


Lys Asp  Met 
    1115     


<210>  2395
<211>  1317
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2395

Met Glu Asn Asn Lys Asn Gln Asn Asn Gln Lys Lys Gln Ser Asn Gln 
1               5                   10                  15      


Lys Pro Ile Ala Gln Lys Pro Lys Arg Gln Arg Arg Arg Gln Ser Thr 
            20                  25                  30          


Asp Phe Lys Ile Ser Leu Thr Gly Lys His Val Tyr Gly Ala Tyr Phe 
        35                  40                  45              


Asn Met Ala Arg Thr Asn Phe Val Lys Thr Ile Asn Tyr Ile Leu Pro 
    50                  55                  60                  


Ile Ala Gly Val Arg Gly Asn Tyr Ser Glu Asn Gln Ile Asn Lys Met 
65                  70                  75                  80  


Leu Gln Ala Leu Phe Leu Val Gln Ala Gly Arg Asn Ser Glu Leu Ser 
                85                  90                  95      


Thr Glu Gln Lys Gln Trp Glu Lys Lys Leu Arg Leu Asn Pro Glu Gln 
            100                 105                 110         


Gln Thr Asn Leu Gln Lys Leu Leu Phe Arg His Phe Pro Val Leu Gly 
        115                 120                 125             


Pro Met Met Ala Asp Val Val Gly His Lys Ala Tyr Leu Asn Lys Lys 
    130                 135                 140                 


Lys Ser Lys Val Gln Thr Glu Asp Glu Ala Phe Ala Gln Leu Arg Gly 
145                 150                 155                 160 


Val Ser Leu Ala Asp Cys Ile Glu Met Ile His Leu Met Ala Val Thr 
                165                 170                 175     


Leu Thr Glu Cys Arg Asn Tyr Tyr Thr His Lys Asp Pro Tyr Asn Ser 
            180                 185                 190         


Pro Ser Gln Leu Ala Ala Gln Cys Gln His Gln Glu Met Ile Ala Lys 
        195                 200                 205             


Lys Leu Asp Lys Val Val Val Ala Ser Arg Arg Ile Leu Lys Asp Arg 
    210                 215                 220                 


Glu Gly Leu Ser Val Asn Glu Val Glu Phe Leu Thr Gly Ile Asp His 
225                 230                 235                 240 


Leu Arg Gln Glu Asp Ala Lys Asp Asp Phe Gly Lys Lys Ile Ile Lys 
                245                 250                 255     


Asp Gly Lys Val Met Lys Thr Phe Val Glu Tyr Asp Asp Phe Tyr Phe 
            260                 265                 270         


Lys Ile Ser Gly Lys Arg His Ile Glu Gly Phe Ser Thr Leu Asp Lys 
        275                 280                 285             


Asp Gly Lys Pro Ile Thr Phe Asn Thr Asp Leu Pro Ala Leu Ser Asp 
    290                 295                 300                 


Phe Gly Leu Leu Tyr Phe Cys Val Leu Phe Leu Ser Lys Pro Tyr Ala 
305                 310                 315                 320 


Lys Phe Phe Ile Asp Glu Thr Arg Leu Phe Glu Phe Ser Pro Phe Thr 
                325                 330                 335     


Glu Glu Glu Asn Leu Ile Met Ser Glu Met Leu Ser Ile Tyr Arg Ile 
            340                 345                 350         


Arg Thr Pro Arg Leu His Lys Ile Asp Ser Arg Asp Ser Lys Ala Thr 
        355                 360                 365             


Leu Ala Met Asp Ile Phe Gly Glu Leu Arg Arg Cys Pro Ile Glu Leu 
    370                 375                 380                 


Tyr Asp Leu Leu Ser Lys Lys Thr Gly Gln Pro Phe Phe His Asp Glu 
385                 390                 395                 400 


Ile Lys Arg Pro Asn Ser His Thr Pro Asp Ile Ser Lys Arg Leu Arg 
                405                 410                 415     


Tyr Asp Asp Arg Phe Pro Thr Leu Ala Leu Arg Tyr Ile Asp Glu Thr 
            420                 425                 430         


Glu Leu Phe Asn Arg Ile Arg Phe Gln Leu Gln Leu Gly Thr Phe Arg 
        435                 440                 445             


Phe Lys Phe Tyr Glu Lys Glu Cys Ile Asp Gly Arg Val Arg Val Arg 
    450                 455                 460                 


Arg Leu Gln Lys Glu Ile Asn Gly Tyr Gly Arg Leu Gln Glu Val Thr 
465                 470                 475                 480 


Asp Lys Arg Leu Glu Lys Trp Gly Asp Leu Ile Gln Lys Arg Glu Glu 
                485                 490                 495     


Arg Ser Val Lys Leu Glu His Glu Glu Met Tyr Ile Asp Leu Asp Gln 
            500                 505                 510         


Phe Gln Arg Asp Thr Ile Asp Ser Thr Pro Tyr Ile Thr Asp Arg Arg 
        515                 520                 525             


Pro Thr Tyr Asn Ile His Ala Asn Arg Ile Gly Met Tyr Trp Glu Ser 
    530                 535                 540                 


Ser Gln Arg Pro Asn Glu Phe Thr Val Phe Asp Ala Asn Lys Met Tyr 
545                 550                 555                 560 


Ile Pro Ile Pro Thr Val Thr Glu Asn Glu Lys Thr Glu Val Asn Met 
                565                 570                 575     


Pro Ala Pro Arg Cys Thr Ile Ser Val His Asp Leu Ser Gly Met Leu 
            580                 585                 590         


Phe Tyr Glu Tyr Leu Arg Asn Gln Leu Asn Asn Asn Thr Thr Ser Ser 
        595                 600                 605             


Ala Glu Glu Ile Ile Ile Asp Cys Glu Asn Asp Tyr Arg Arg Phe Phe 
    610                 615                 620                 


Lys Ala Val Ala Asp Gly Ser Leu Met Pro Phe Gln Lys Thr Lys Glu 
625                 630                 635                 640 


Phe Arg Glu Tyr Leu Lys Glu Asn Tyr Ser Lys Leu Arg Leu Ala Asp 
                645                 650                 655     


Ile Pro Glu Lys Leu Val Leu Tyr Leu Thr Ser Lys Gly Gln Thr Tyr 
            660                 665                 670         


Lys Gly Lys Pro Val Thr Ala Arg Glu Lys Met Val Leu Leu Ala Ile 
        675                 680                 685             


Glu His Leu Glu Glu Arg Glu Arg Ser Val Gln Arg Arg Leu Glu His 
    690                 695                 700                 


Tyr Gln Glu Asp Arg Lys Met Ile Gly Asp Lys Asp Asn Lys Tyr Gly 
705                 710                 715                 720 


Lys Lys Ser Phe Ala Asp Val Arg His Gly Ala Leu Ala Arg Tyr Leu 
                725                 730                 735     


Ala Gln Ser Met Met Glu Trp Gln Pro Ser Lys Asp Gly Glu Gly His 
            740                 745                 750         


Asp Lys Leu Thr Gly Leu Asn Tyr Asn Val Leu Thr Ala Tyr Leu Ala 
        755                 760                 765             


Thr Phe Gly Ala Pro Gln Val Ile Glu Asp Glu Asn Phe Val Pro Arg 
    770                 775                 780                 


Ser Leu Leu Glu Val Leu Lys Glu Thr Lys Met Val Asp Asp Gly Asn 
785                 790                 795                 800 


Pro His Pro Phe Ile Asn Lys Val Leu Ala Leu Gly Asn Arg Asn Ile 
                805                 810                 815     


Glu Glu Leu Tyr Leu His Tyr Leu Thr Glu Glu Leu Asn His Ile His 
            820                 825                 830         


Ser Cys Met Lys Ser Leu Lys Asp Asn Pro Thr Asp Lys Ala Leu Ser 
        835                 840                 845             


Ala Leu Pro Phe Val His Tyr Lys Arg Thr Arg Tyr Arg Glu Arg Thr 
    850                 855                 860                 


Ala Glu Glu Met Lys Ala Leu Ala Ala Arg Tyr Thr Thr Ile Gln Leu 
865                 870                 875                 880 


Pro Asp Gly Leu Phe Thr Pro Tyr Ile Val Asp Leu Leu Lys Gln Ser 
                885                 890                 895     


Tyr Pro Asp Asn Ile Ala Leu Gln Asn Ala Ile Asn Gln Asp Met Pro 
            900                 905                 910         


Asp Lys Leu Asn Pro Ile His Asn Ala Ala Tyr Leu Ile Ser Leu Phe 
        915                 920                 925             


Tyr Gln Thr Val Lys Lys Asp Glu Ala Gln Pro Phe Tyr Gln Ser Gly 
    930                 935                 940                 


Val Thr Tyr Ser Arg Glu Asn Glu Asn Gly Glu Leu Glu Lys Phe Ser 
945                 950                 955                 960 


Phe Lys Arg Ser Tyr Glu Leu Phe Ser Val Leu Asn Asn Lys Lys Gln 
                965                 970                 975     


Ala Thr Phe Pro Phe Glu Leu Ile Pro Leu Phe Leu Thr Ser Asp Glu 
            980                 985                 990         


Ile Gln Glu Arg Leu Thr Ala Lys  Leu Leu Asp Asp Gln  Gly Asp Pro 
        995                 1000                 1005             


Ile Pro  Glu Ala Gly Lys Arg  Gly Lys Ala Ala Thr  Asp Ser Gln 
    1010                 1015                 1020             


Gly Asn  Ile Ile Trp Gln Arg  Gln Ile Lys Asn Thr  Ile Asn Ser 
    1025                 1030                 1035             


Phe Val  Glu Thr Leu Gly Tyr  Lys Asp Leu Lys Val  Ser Thr Asn 
    1040                 1045                 1050             


Gln Pro  Asn His Lys Lys Glu  Glu Glu Leu Ala Asn  Lys Arg Glu 
    1055                 1060                 1065             


Ala Leu  Arg Ser Arg Leu Thr  Arg Gln Val Asn Glu  Ile Lys Asn 
    1070                 1075                 1080             


Asn Glu  Arg Thr Leu Arg Arg  Tyr Lys Val Gln Asp  Met Val Leu 
    1085                 1090                 1095             


Phe Leu  Leu Ala Lys Gly Ile  Phe Ala Asp Ile Ile  Asn Glu Gln 
    1100                 1105                 1110             


Gly Lys  Asp Val Asn Trp Glu  Gln Met Lys Leu Ser  Lys Val Cys 
    1115                 1120                 1125             


Glu Asp  Thr Phe Leu Arg Gln  Thr Met Thr Tyr Arg  Val Pro Val 
    1130                 1135                 1140             


Ile Val  Gly Glu Lys Thr Ile  Tyr Val Glu Gln Glu  Asn Met Ser 
    1145                 1150                 1155             


Leu Lys  Asn Tyr Gly Glu Phe  Tyr Arg Phe Leu Thr  Asp Asp Arg 
    1160                 1165                 1170             


Leu Met  Ser Leu Leu Glu Asn  Ile Val Asp Asn Leu  Asn Pro Asn 
    1175                 1180                 1185             


Glu Lys  Gly Glu Leu Val Ile  Arg His Thr Asp Leu  Met Ser Glu 
    1190                 1195                 1200             


Leu Ala  Ala Tyr Asp Gln Asn  Arg Ser Thr Ile Phe  Lys Leu Ile 
    1205                 1210                 1215             


Gln Gln  Ile Glu Asp Ile Ile  Ile Lys Asn Asn Asp  Thr Leu Lys 
    1220                 1225                 1230             


Asn Pro  His Ser Glu Asp Phe  Trp Ala His Glu Gly  Leu Pro Lys 
    1235                 1240                 1245             


Arg Asn  Asn Phe Ala Ser Leu  Leu Glu Leu Ile Asp  Gln Leu Asn 
    1250                 1255                 1260             


Gly Val  Ala Leu Thr Asp Asp  Glu Arg Lys Leu Leu  Ile Ala Ile 
    1265                 1270                 1275             


Arg Asn  Ala Phe Ser His Asn  Ser Tyr Asn Ile Asp  Leu Ser Leu 
    1280                 1285                 1290             


Ile Lys  Asp Val Lys His Leu  Pro Glu Val Ala Lys  Gly Ile Leu 
    1295                 1300                 1305             


Gln His  Leu Glu Thr Lys Val  Gly Ala 
    1310                 1315         


<210>  2396
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2396

Met Glu Thr Lys Gln Gln Val Gly Lys Gly Ile Ser Tyr Asp His Arg 
1               5                   10                  15      


Arg Pro Asp Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asp Gly Val Ile Gln Glu Phe Ala Met Arg Leu Asn Arg 
        35                  40                  45              


Glu Tyr Asp Pro Glu Asn Lys Asn Gln Ser Leu Phe Ser Tyr Phe Asn 
    50                  55                  60                  


Ile Asn Ala Ser Phe Thr Asp Trp Glu Arg Gly Val Asn Ile Leu Lys 
65                  70                  75                  80  


Glu Tyr Trp Pro Met Met Glu Phe Ile Asp Arg Pro Ala Thr Asp Lys 
                85                  90                  95      


Gln Phe Glu Ala Glu Lys Pro Glu Asn Arg Glu Ala Ala Lys Arg Lys 
            100                 105                 110         


Tyr Phe Leu Ala Thr Leu Gly Ala Leu Leu Thr Ser Ile Lys Asp Leu 
        115                 120                 125             


Arg His Tyr Tyr Thr His Tyr Tyr His Pro Pro Val His Leu Asn Asp 
    130                 135                 140                 


Asp Leu Phe Leu Phe Leu Asp His Ala Leu Leu Tyr Thr Ala Phe Asp 
145                 150                 155                 160 


Val Lys Lys Thr Lys Met Lys Asp Asp Lys Thr Arg Gln Leu Leu Asn 
                165                 170                 175     


Gln Asn Leu Ser Leu Glu Leu Glu Lys Leu Lys Lys Leu Lys Val Glu 
            180                 185                 190         


Glu Leu Lys Lys Lys Lys Glu Lys Gly Ile Lys Val Asn Leu Gln Asp 
        195                 200                 205             


Glu Lys Gly Ile Leu Asn Ala Ile Tyr Asn Asp Ala Phe Ala His Ile 
    210                 215                 220                 


Ile Thr Lys Glu Lys Asp Ser Asp Lys Asp Lys Leu Glu Thr Arg Tyr 
225                 230                 235                 240 


Lys Ser Ile Leu Pro Gln Asp Glu Ala Ala Glu Thr Gly Ile Asn Ile 
                245                 250                 255     


Ser Ile Ser Gly Leu Ile Phe Leu Leu Ser Leu Phe Leu Ser Arg Lys 
            260                 265                 270         


Glu Ile Glu Gln Leu Lys Ser Asn Ile Glu Gly Tyr Lys Gly Lys Val 
        275                 280                 285             


Leu Asn Ile Glu Thr Glu Val Asp Arg Lys His Asn Ser Leu Lys Tyr 
    290                 295                 300                 


Met Ala Thr His Trp Val Phe Ser Ile Leu Ala Phe Lys Gly Leu Lys 
305                 310                 315                 320 


Gln Arg Leu Thr Asn Ser Phe Glu Lys Glu Ser Leu Leu Ile Gln Met 
                325                 330                 335     


Met Asp Glu Leu Asn Lys Val Pro Asp Glu Leu Tyr Gln Thr Leu Ser 
            340                 345                 350         


Glu Thr Ala Lys Lys Glu Phe Leu Glu Asp Ile Asn Glu Tyr Val Ser 
        355                 360                 365             


Glu Gly Asp Asp Asn Glu Lys Ala Thr Tyr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Ser Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gln Phe Pro Thr Leu Lys Phe Gln Ile Phe Val Gly 
                405                 410                 415     


Gln Tyr Leu His Asp Asn Arg Pro Lys Thr Leu Ala Ser Asn Gly Met 
            420                 425                 430         


Thr Ala Gln Arg Met Ile Lys Glu Lys Ile Asn Leu Phe Gly Asn Leu 
        435                 440                 445             


Ser Glu Val Thr Lys His Lys Ser Asp Phe Phe Glu Lys Glu Ser Ala 
    450                 455                 460                 


Ala Gln Gly Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Trp Ala Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Val Tyr Ile Asp Met Ile Gly Lys Glu Gly Lys Ala 
                485                 490                 495     


Lys Glu Ile Gln Val Gln Ile Asn Lys Tyr Arg Lys Gln Leu Asn Pro 
            500                 505                 510         


Ala Pro Gln Arg Asp Lys Arg Ile Ser Lys Lys Glu Ile Ile Glu Gln 
        515                 520                 525             


Leu Tyr Lys Glu Lys Val Val Tyr Gly Asp Pro Thr Leu Met Leu Ser 
    530                 535                 540                 


Ala Asn Glu Leu Met Ala Leu Leu Tyr Glu Leu Ile Val Asn Gly Lys 
545                 550                 555                 560 


Ser Gly Ala Glu Leu Glu Asn Lys Ile Val Glu Gln Ile Ile Ala Arg 
                565                 570                 575     


Tyr Glu Gln Ile Glu Ala Tyr Asp Pro Thr Thr Gln Gln Leu Pro Thr 
            580                 585                 590         


Asn Gln Met Pro His Lys Leu Gln Lys Ser Arg Lys Asp Ser Lys Val 
        595                 600                 605             


Thr Asp Thr Asp Lys Leu Leu Lys Thr Ile Asp Lys Glu Ile Asp Glu 
    610                 615                 620                 


Gly Asn Lys Lys Leu Glu Leu Ile Ala Cys His Arg Lys Glu Trp Glu 
625                 630                 635                 640 


Glu Ala Glu Gln Arg Lys Lys Ser Gly Lys Arg Asn Asn Pro Gly Thr 
                645                 650                 655     


Lys Ser Arg Lys His Leu Phe Tyr Ala Ser Glu Met Gly Glu Glu Ala 
            660                 665                 670         


Thr Trp Ile Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Pro Ala Arg 
        675                 680                 685             


Ala Glu Trp Lys Gly Thr His His Ser Glu Leu Gln Arg Leu Leu Ala 
    690                 695                 700                 


Phe Tyr Ser Thr Gln Arg Leu Glu Ala Trp Gln Leu Val Glu Ser Val 
705                 710                 715                 720 


Trp Thr Ala Asn Thr His Ser Phe Trp Glu Glu Asn Phe Lys Glu Ala 
                725                 730                 735     


Phe Tyr Lys Pro Glu Phe Glu Asn Phe Tyr Gly Ala Tyr Ile Glu Ile 
            740                 745                 750         


Arg Thr Lys Ile Leu Thr Thr Cys Arg Ser Ile Leu Glu Asn Asn Pro 
        755                 760                 765             


Glu Ala Thr Met Asn Asn Asp Thr Glu Lys Glu Trp Asp Lys Val Phe 
    770                 775                 780                 


Thr Leu Phe Asp Lys Arg Leu Tyr Arg Thr Ser Thr Thr Asp Glu Gln 
785                 790                 795                 800 


Lys Lys Gln Leu Leu Thr Lys Pro Phe Ala Phe Pro Arg Gly Leu Phe 
                805                 810                 815     


Asp Asp Lys Pro Thr Phe Leu Pro Gly Ser Lys Pro Asn Glu Asn Pro 
            820                 825                 830         


Glu Arg Phe Ala Ala Trp Tyr Ser Tyr Gly Tyr Thr Tyr Ser Gly Lys 
        835                 840                 845             


Phe Gln Ser Phe Tyr Asp Met Pro Arg Asn Tyr Ser Asp Trp Tyr Lys 
    850                 855                 860                 


Lys Leu Lys Glu Asp Gly Lys Leu Pro Arg Leu Asp Lys Lys Thr Glu 
865                 870                 875                 880 


Gln Glu Lys Ile Leu Arg Phe Arg Met Asp Cys Asp Leu Asn Ile Lys 
                885                 890                 895     


His Ile Arg Phe Gln Asp Ile Tyr Val Lys Leu Met Val Asp Ser Leu 
            900                 905                 910         


Tyr Lys Ala Val Phe Gly Gln Gln Pro Glu Phe Asp Leu Ser His Leu 
        915                 920                 925             


Tyr Asp Thr Arg Ser Glu Arg Tyr Glu Asn Asn Thr Ile Ala Gln Arg 
    930                 935                 940                 


Gln Lys Ser Arg Gln Glu Gly Asp Asn Ser Asp Asn Ala Ile Asn Glu 
945                 950                 955                 960 


Asn Tyr Val Trp Asn Lys Thr Phe Ala Ile Ser Leu Tyr Asn Gly Arg 
                965                 970                 975     


Ile Thr Glu Ser Gln Val Lys Leu Lys Asp Val Gly Lys Phe Arg Arg 
            980                 985                 990         


Phe Ala Thr Asp Pro Arg Val Gln  Thr Leu Ile Ser Tyr  Asp Asp Thr 
        995                 1000                 1005             


Arg Thr  Trp Thr Lys Leu Glu  Ile Glu Asn Glu Leu  Asp Asn Lys 
    1010                 1015                 1020             


Ala Asp  Ala Tyr Glu Pro Ile  Arg Arg Thr Gln Ser  Leu Lys Ala 
    1025                 1030                 1035             


Ile Gln  Gln Leu Glu Lys Asn  Ile Leu Lys Lys Asn  Gly Phe Asn 
    1040                 1045                 1050             


Gly Lys  Gln His Pro Glu Glu  Leu Lys His Asn Gly  Asn Pro Asn 
    1055                 1060                 1065             


Phe Arg  Lys Tyr Ile Ala Asn  Gly Leu Leu Lys His  Arg Thr Asp 
    1070                 1075                 1080             


Ile Arg  Gln Glu Glu Leu Ala  Leu Ile Ser Asp Thr  Glu Phe Gln 
    1085                 1090                 1095             


Glu Ile  Gly Leu Glu Arg Ile  Arg Gln Thr Asn Pro  Leu Ile Gln 
    1100                 1105                 1110             


Lys Ala  Tyr Leu Leu Ile Leu  Leu Arg Asn Lys Phe  Gly His Asn 
    1115                 1120                 1125             


Gln Leu  Pro Asp Gln Glu His  Phe Arg Leu Met Arg  Ser Ile Tyr 
    1130                 1135                 1140             


Pro Tyr  Asn Gln Gln Glu Ser  Tyr Ser Ala Tyr Phe  Asn His Val 
    1145                 1150                 1155             


Ile Thr  Gln Ile Ile Glu Glu  Leu Asn Thr 
    1160                 1165             


<210>  2397
<211>  1140
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2397

Met Glu Asn Asp Gln Gln Ile Leu Glu Asn Arg Arg Arg Thr Leu Ala 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Ser Asn His Leu Ala Ala Ser Phe Glu Gln Lys Val 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ala Ser Phe Leu Cys Asn Lys Ser 
    50                  55                  60                  


Ile Lys Lys Ile Asn Trp Asn His Val Tyr Ser Lys Ala Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ala Asp Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Arg Glu Thr Thr Asp Lys Glu Gly Lys Asp Phe Thr Ala Met Asn Glu 
            100                 105                 110         


Thr Leu Lys Leu Val Phe Asp Glu Leu Gln Ala Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Ala Asp Ser Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Val Glu Leu Ala Asp Phe Leu Thr Val Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Ala Asp Asp Asp Tyr 
                165                 170                 175     


Thr Met Val Glu Ser Lys Gln Ile Val Thr Pro Asp Asn Leu Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Val Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Leu Ala Tyr Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asp Leu Gly Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Glu 
            260                 265                 270         


Val Ile Thr Glu Glu Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Glu Glu Glu Arg 
    290                 295                 300                 


Glu Lys Ile Leu Asp Glu Ile Asp Tyr Glu Asp Tyr Ile Glu Ser Leu 
305                 310                 315                 320 


Thr Arg Arg Val Arg His Ser Asn Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Lys Tyr Asn Lys Gln Phe Asp Gly Glu 
        355                 360                 365             


Ala Thr Glu Cys Lys Val Val Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asn Gln Glu Thr Val Glu Leu Lys Ile Asp Ser Ala 
385                 390                 395                 400 


Gln Arg Thr Asn Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Glu Ala Arg Leu Leu 
            420                 425                 430         


Thr Lys Ala Lys Pro Glu Ser Lys Val Ser Tyr Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Lys Ala Glu Glu Met Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Lys Val Asn Asp Ser Gln Leu Met Ser Met Gln Phe Ile Asp Glu 
                485                 490                 495     


Ile Lys Glu Gln Leu Pro Ala Asp Trp Asn Glu Phe Gly Lys Arg Ser 
            500                 505                 510         


Asp Ser Lys Lys Lys Lys Ala Tyr Thr Asn Ala Ala Leu Gln Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Lys Val Leu Ala Asn Tyr Gln Leu 
    530                 535                 540                 


Asn Asp Lys Gln Val Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Ser Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Val Glu Lys His Lys Leu 
            580                 585                 590         


Asp Lys Ser Ala Arg Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Thr Asp Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Phe Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Tyr 
625                 630                 635                 640 


Ala Asp Thr Asp Lys Lys Ala Thr Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Lys Gly Gly His Pro Phe Leu Ala Asn Ile Asn 
            660                 665                 670         


Leu Arg Gln Ile Arg Lys Thr Ser Gln Leu Tyr Glu Leu Tyr Leu Val 
        675                 680                 685             


Glu Lys Ala Asn Lys Gln Val Lys Lys Met Asn Pro Lys Thr Gln Arg 
    690                 695                 700                 


Thr Ser Asn Val Asp Glu Ser Trp Met Met Lys Ser Phe Tyr Ala Lys 
705                 710                 715                 720 


Glu Trp Asn Glu Glu Met Gly Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Val Asn Lys Thr Asn Ile Pro Phe Thr Ile Arg Gln Trp Glu Glu Lys 
            740                 745                 750         


Glu Lys His Asn Leu Gln Ala Trp Leu His Asn Ile Thr Lys Gly Lys 
        755                 760                 765             


Thr Ser Lys Asp Gly Lys Lys Ala Ile Asp Leu Pro Thr Asn Leu Phe 
    770                 775                 780                 


Asp Asp Thr Leu Cys Glu Leu Leu Arg Glu Ala Leu Ile Asn Gln Gly 
785                 790                 795                 800 


Ile Asp Ala Thr Pro Thr Thr Lys Tyr Asn Glu Leu Leu Lys Gln Trp 
                805                 810                 815     


Trp Thr Ala Arg Glu Asp Ser Thr Gln Asp Phe Tyr Leu Ser Glu Arg 
            820                 825                 830         


Gln Tyr Asp Ile Tyr Asp Glu Lys Val Cys Phe Thr Ile Asn Ser Ser 
        835                 840                 845             


Ala His Phe Ala Asp Tyr Tyr Ala Pro Ala Leu Asn Lys Ala Tyr Ser 
    850                 855                 860                 


Arg Leu Arg Ala Glu Arg Asp Val Ala Arg Arg Thr Asp Lys Arg Leu 
865                 870                 875                 880 


Pro Pro Val Glu Arg Lys Asp Val Glu Arg Val Phe Lys Asn Thr Ile 
                885                 890                 895     


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
            900                 905                 910         


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asn Gln Gln Gln Leu Lys 
        915                 920                 925             


Leu Ser Lys Met Asp Ser Leu Leu Asn Glu Thr Lys Arg Ile Glu Gln 
    930                 935                 940                 


Thr Ile Asn Thr Gln Leu Ser Phe Asp His Lys Gly Lys Glu Ile Lys 
945                 950                 955                 960 


Asp Lys Thr Asn Ser Glu Ile Val Lys Thr Ile Val Ala Glu Arg Lys 
                965                 970                 975     


Gln Lys Asn Tyr Thr Glu Met Arg Lys Tyr Val His Asp Arg Arg Leu 
            980                 985                 990         


Pro Glu Leu Phe Glu Tyr Ile Asp  Gly Asn Glu Leu Pro  Leu Asp Val 
        995                 1000                 1005             


Leu Leu  Asn Glu Leu Arg Ala  Tyr Asn Thr Ala Lys  Gln Met Val 
    1010                 1015                 1020             


Phe Asp  Thr Val Phe Ala Leu  Glu Lys Lys Ile Ile  Glu Thr Asp 
    1025                 1030                 1035             


Pro Glu  Gly Leu Lys Gln Leu  Asn Val Gly Lys Asn  Gly Gln Ile 
    1040                 1045                 1050             


Gln Thr  Gly Asn Ile Gln His  Lys Pro Tyr Val Gln  Trp Leu Glu 
    1055                 1060                 1065             


Asn Lys  Gly Leu Ile Thr Asp  His Gln Lys Gln Phe  Ile Asn Met 
    1070                 1075                 1080             


Val Arg  Asn Ser Phe Ser His  Asn Gln Phe Pro Gln  Arg Ser Thr 
    1085                 1090                 1095             


Val Glu  Leu Leu Met Pro Glu  Trp Gln Asn Thr Asp  Ile Ala Leu 
    1100                 1105                 1110             


Gln Ile  Ala Arg Glu Tyr Gln  Gln Leu Ile Val Asp  Ile Ile Glu 
    1115                 1120                 1125             


Lys Ser  Leu His Pro His Lys  Gln His Gln Met Val  
    1130                 1135                 1140 


<210>  2398
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2398

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Thr 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2399
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2399

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Pro 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Ala Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2400
<211>  1141
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2400

Met Thr Gln Thr Ala Thr Thr Asn Ser Gly Thr Leu Ala Asp Asp Lys 
1               5                   10                  15      


Gln Thr Tyr Tyr Tyr His Phe Leu Lys Ser Asp Lys Phe Phe Phe Gly 
            20                  25                  30          


Ser Phe Phe Asn Leu Ala Asp Asn Asn Leu Lys Ala Thr Phe Asn Asp 
        35                  40                  45              


Phe Glu Lys Arg Leu Gly Ile Lys Ser Ala Asn Gly Leu Val Gln Lys 
    50                  55                  60                  


Val Glu Gln Tyr Phe Pro Asp Asn Leu Leu Leu Ser Glu Phe Glu Arg 
65                  70                  75                  80  


Arg Thr Glu Leu Leu Thr Glu Tyr Leu Pro Ile Val His Lys Leu Arg 
                85                  90                  95      


Lys Ile Asn Lys Glu Ser Ala Glu Pro Asp Arg Ser Tyr Phe Arg Asp 
            100                 105                 110         


Asn Leu Lys Met Leu Ile Lys Ala Val Asp His Leu Arg Asn Phe Tyr 
        115                 120                 125             


Thr His Tyr Tyr His Lys Ser Ile Ile Phe Asp Glu Arg Leu Phe Glu 
    130                 135                 140                 


Phe Leu Asn Gly Ala Leu Leu Asn Val Cys Phe Asp Val Lys Lys Lys 
145                 150                 155                 160 


Arg Met Lys Ser Asp Thr Asn Lys Ala Phe Leu Lys Lys His Phe Glu 
                165                 170                 175     


Glu Asn Phe Ile Asn Lys Ser Lys Asp Lys Ile Lys Glu Ala Phe Asp 
            180                 185                 190         


Glu Ala Phe Ser His Leu Lys Val Ser Asn Asp Gly Lys Lys Phe Ser 
        195                 200                 205             


Leu Thr Lys Phe Tyr Gln Ala Lys Leu Ser His Lys Gln Lys Phe Ser 
    210                 215                 220                 


Val Lys Asn Asp Leu Ile Phe Asp Ile Thr Asn Ser Asp Phe Val Phe 
225                 230                 235                 240 


Leu Ser Asn Ser Gly Leu Leu Phe Leu Leu Ser Phe Phe Leu Arg Arg 
                245                 250                 255     


Glu Glu Gln Glu Gln Leu Leu Ser Lys Met Glu Gly Phe Lys Asn Gln 
            260                 265                 270         


Asn Glu Leu Asn Phe Ile Ala Thr Arg Trp Val Phe Thr His Lys Cys 
        275                 280                 285             


Phe Lys Gly Leu Lys Lys Thr Ile Lys Ser Ser Tyr Asp Lys Glu Thr 
    290                 295                 300                 


Leu Leu Met Gln Met Val Asp Glu Leu Ser Lys Cys Pro Asp Val Leu 
305                 310                 315                 320 


Tyr Lys Asn Leu Ser Asp Lys Gln Lys Gln Glu Phe Val Val Asp Val 
                325                 330                 335     


Asn Glu Phe Tyr Gln Glu Ala Lys Glu Gln Asn Glu Glu Asn Lys Leu 
            340                 345                 350         


Val Ser His Thr Ile Ile Arg Lys Arg Tyr Glu Asp Lys Phe Ala Tyr 
        355                 360                 365             


Phe Ala Leu Arg Phe Leu Asp Glu Phe Ala Asn Phe Pro Thr Leu Arg 
    370                 375                 380                 


Phe Gln Val Val Val Gly Asn Tyr Leu Gln Asn Glu Gln Glu Lys Gln 
385                 390                 395                 400 


Ile Lys Asn Thr Thr Thr Val Leu Lys Thr Asn Arg Gln Ile Lys Glu 
                405                 410                 415     


Arg Ile Lys Met Phe Gly Lys Leu Ser Thr Leu Ser Ser Lys Lys Ala 
            420                 425                 430         


Ala Tyr Phe Lys Ala Ile Leu Glu Asp Arg Thr Leu Thr Ala Glu Glu 
        435                 440                 445             


Lys Gly Leu Asp Pro Lys Trp Glu Ile Phe Pro Asn Pro Ser Tyr Gly 
    450                 455                 460                 


Phe Lys Gly Asn Asn Ile Pro Ile Tyr Ile Asn Lys Lys Gly Phe Lys 
465                 470                 475                 480 


Asn Met Leu Ser Val Asp Glu Ala Lys Val Arg Thr Asn Lys Asp Arg 
                485                 490                 495     


Ala Ala Lys Lys Asp Ile Ile Glu Lys Ile Phe Gly Lys Asp Asn Tyr 
            500                 505                 510         


Tyr Gly Lys Pro Ile Ala Tyr Leu Ser Leu Asn Glu Leu Pro Ala Leu 
        515                 520                 525             


Leu Tyr Glu Phe Leu Val Asn Gly Lys Asn Gly Val Asp Ile Glu Asn 
    530                 535                 540                 


Ile Ile Phe Asn Lys Ile Lys Gln Gln Val Val Ala Ile Lys Ala Ala 
545                 550                 555                 560 


Asp Lys Thr Asn Lys Gly Ile Pro Asn Lys Leu Arg Lys Ala Lys Glu 
                565                 570                 575     


Glu Asn Asp Tyr Asp Leu Asn Lys Leu Lys Gly Asn Ile Lys Asp Gln 
            580                 585                 590         


Ile Asp Glu Cys Asn Glu Lys Ile His Phe Ile Arg Thr Cys Arg Ala 
        595                 600                 605             


Ala Phe Asp Pro Asn Lys Thr Lys His Phe Phe Thr Leu Lys Gln Leu 
    610                 615                 620                 


Gly Asp Glu Ala Thr Trp Leu Ala Asp Asp Ile Lys Arg Phe Met Leu 
625                 630                 635                 640 


Pro Glu Ala Arg Lys Asn Trp Lys Ala Tyr Glu His Ser Glu Phe Gln 
                645                 650                 655     


Arg Leu Leu Ala Phe Tyr Lys Arg Phe Arg Lys Asp Ala Arg Gln Leu 
            660                 665                 670         


Leu Lys Asn Lys Trp Thr Met Asn Asp Thr Phe Gly Glu Met Val Lys 
        675                 680                 685             


Arg Cys Phe Ser Gln Val Glu Phe Asp Gln Phe Tyr Glu Met Tyr Leu 
    690                 695                 700                 


Ile Asp Lys Ile Glu Gln Leu Glu Val Tyr Lys Asn Gln Leu Asp Gly 
705                 710                 715                 720 


Glu Ala Ile Gln Ser His Pro Lys Leu Leu Lys Lys Val Leu Lys Glu 
                725                 730                 735     


Ile Phe Arg Tyr Phe Asn Glu Arg Leu Tyr Leu Ile Lys Pro Ala Gly 
            740                 745                 750         


Lys Gln Ile Glu Glu Leu Leu Lys His Pro Ile Asn Leu Pro Arg Gly 
        755                 760                 765             


Ile Phe Asp Asn Arg Pro Thr Tyr Ile Glu Asn Ala Asn His Thr Asp 
    770                 775                 780                 


His Lys Asp Gln Tyr Ala Ala Trp Phe Leu His Ile Thr Lys Asn Glu 
785                 790                 795                 800 


Asn Glu Leu Gln Gln Phe Tyr Ser Phe Ala Trp Asn Ile Asn Asn Asp 
                805                 810                 815     


Lys Thr Leu Asp Tyr Glu Lys Leu Thr Lys Glu Lys Met Lys Arg Leu 
            820                 825                 830         


Glu Lys Lys Arg Lys Arg Gln Gly Lys Thr Asn Gln Asn Phe Ser Gln 
        835                 840                 845             


Asn Asn Ser Ile Asn Phe Asn Asn Leu Lys Glu Lys Ile Lys Ile Arg 
    850                 855                 860                 


Leu Gln Lys Asp Ala Lys Ala Ala Ile Asn Lys Gln Ile Arg Ser Asp 
865                 870                 875                 880 


Val Phe Ile Lys Ala Met Ala Asp Tyr Val Phe Glu Lys Thr Phe Asp 
                885                 890                 895     


Lys Pro Tyr Gln Ile Pro Leu Asn Glu Ile Tyr Gln Asn Lys Ala Gln 
            900                 905                 910         


Lys Glu Gln Met Arg Asn Glu Ala Ala Ala Gln Gln Ser Arg Ala Glu 
        915                 920                 925             


Gly Asp Lys Ser Ser Asn Ile Tyr Asn Glu Thr Phe Ile Trp Asn Lys 
    930                 935                 940                 


Val Ile Ser Tyr Ser Ile Phe Gly Gly Lys Ile Lys Glu Glu Lys Leu 
945                 950                 955                 960 


Lys Leu Lys Asp Ile Gly Lys Phe Arg Ala Leu Glu Gln Asn Pro Lys 
                965                 970                 975     


Val Lys Ala Ile Val Thr Tyr Pro His Asn Asp Asp Trp Ser Lys Thr 
            980                 985                 990         


Glu Ile Glu Lys Glu Leu Thr Asn  Tyr Glu Arg Ile Arg  Ser Glu Thr 
        995                 1000                 1005             


Leu Leu  Lys Ser Val Gln Glu  Ile Glu Lys Lys Val  Leu Gln Lys 
    1010                 1015                 1020             


Leu Gln  Thr Gly Thr Val His  Pro Lys Ile Leu Glu  His Lys Gly 
    1025                 1030                 1035             


Asn Pro  Gln Phe Arg Lys Tyr  Val Val Glu Gly Phe  Leu Lys Asp 
    1040                 1045                 1050             


Met Ile  Ala Glu Pro Glu Leu  Thr Phe Phe Asn Asn  Asn Lys Thr 
    1055                 1060                 1065             


Ile Asp  Asn Phe Ser Ile Ser  Glu Val Glu Glu Gln  Ala Leu Leu 
    1070                 1075                 1080             


Ile Gln  Gln Ala Phe Tyr Leu  Ile Leu Ile Arg Asn  Lys Phe Ala 
    1085                 1090                 1095             


His Asn  Gln Leu Pro Asn Val  Ala Phe Phe Glu Ala  Met Ile Asn 
    1100                 1105                 1110             


Ile Ser  Gly Ile Glu Lys Arg  Asn Asp Asn Phe Ala  Ala Gln Leu 
    1115                 1120                 1125             


Asn Gln  Ile Phe Asp Thr Phe  Lys Ala Glu Ile Ile  Lys 
    1130                 1135                 1140     


<210>  2401
<211>  985
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2401

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Asn Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys Gly Tyr 
                165                 170                 175     


Ala Phe Phe Ile Ser Lys Phe Leu Glu Arg Lys Tyr Ser Tyr Leu Phe 
            180                 185                 190         


Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln Tyr Arg 
        195                 200                 205             


Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro Val Glu 
    210                 215                 220                 


Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu Asp Ile 
225                 230                 235                 240 


Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr Leu Glu 
                245                 250                 255     


Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr Asp Ala 
            260                 265                 270         


Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe Arg Ser 
        275                 280                 285             


Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala Asp Phe 
    290                 295                 300                 


Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His Asn Gly 
305                 310                 315                 320 


Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr Ile Asn 
                325                 330                 335     


Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser Ala Lys 
            340                 345                 350         


Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser Thr Asp 
        355                 360                 365             


Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln Ser Thr 
    370                 375                 380                 


Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val Leu Pro 
385                 390                 395                 400 


Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala Lys Met 
                405                 410                 415     


Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala Met Leu 
            420                 425                 430         


Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His Cys Pro 
        435                 440                 445             


Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser Thr Lys 
    450                 455                 460                 


Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg Val Met 
465                 470                 475                 480 


Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu Arg Ile 
                485                 490                 495     


Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile Leu Lys 
            500                 505                 510         


Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp Leu Gln 
        515                 520                 525             


Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn Phe Gln 
    530                 535                 540                 


Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn Asp Leu 
545                 550                 555                 560 


Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn Pro His 
                565                 570                 575     


Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile Glu Phe 
            580                 585                 590         


Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg Ile Gln 
        595                 600                 605             


Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro Leu Arg 
    610                 615                 620                 


Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu Ala Ile 
625                 630                 635                 640 


Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys Leu Lys 
                645                 650                 655     


Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu Lys Ser 
            660                 665                 670         


Pro Ala Leu Asn Val Ser Tyr Leu Ile His Asn Tyr Phe Arg Ala Tyr 
        675                 680                 685             


Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn Tyr Arg 
    690                 695                 700                 


Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser Tyr Leu 
705                 710                 715                 720 


Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro Ser Lys 
                725                 730                 735     


Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp Arg Leu 
            740                 745                 750         


Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile Ile Arg 
        755                 760                 765             


Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys Glu Tyr 
    770                 775                 780                 


Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu Glu Asn 
785                 790                 795                 800 


Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp Leu Asn 
                805                 810                 815     


Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr Gly Lys 
            820                 825                 830         


Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn Lys Val 
        835                 840                 845             


Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val Lys Ile 
    850                 855                 860                 


Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu Glu Ala 
865                 870                 875                 880 


Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala Met Val 
                885                 890                 895     


Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr Tyr Asp 
            900                 905                 910         


Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln Lys Ile 
        915                 920                 925             


Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His Asp Lys 
    930                 935                 940                 


Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val Tyr Ala 
945                 950                 955                 960 


Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile Lys Leu 
                965                 970                 975     


Glu Asp Leu Ser Asn Asp Ser Ser Ala 
            980                 985 


<210>  2402
<211>  1175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2402

Met Thr Glu Gln Asn Glu Lys Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Thr His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Phe Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Lys Tyr Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Gly Lys Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Thr Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Ala 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Phe Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Glu Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Asp Glu Ile Asn Thr Arg Asp 
    530                 535                 540                 


Glu Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Lys His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Gly Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Leu Asp Glu Val Arg Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Ser Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Asp Leu Glu Ala Trp Ser His Ser Ala Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Ala Gly Ile Glu Asn Ala Ser Arg Glu Asn 
    850                 855                 860                 


Lys Lys Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Glu Thr 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Lys Ala Asp Lys Ile Asn Ile Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Ala Lys Glu His Pro Tyr Leu Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asp Ile Arg Thr 
945                 950                 955                 960 


Asp Val Gln Glu Gln Gly Ser Leu Asn Val Leu Asn His Val Lys Pro 
                965                 970                 975     


Met Arg Leu Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val 
            980                 985                 990         


His Lys Glu Gln Ala Pro Leu Ala  Thr Val Tyr Ile Glu  Glu Arg Asp 
        995                 1000                 1005             


Thr Lys  Leu Leu Lys Gln Gly  Asn Phe Lys Ser Phe  Val Lys Asp 
    1010                 1015                 1020             


Arg Arg  Leu Asn Gly Leu Phe  Ser Phe Val Asp Thr  Gly Gly Leu 
    1025                 1030                 1035             


Ala Met  Glu Gln Tyr Pro Ile  Ser Lys Leu Arg Val  Glu Tyr Glu 
    1040                 1045                 1050             


Leu Ala  Lys Tyr Gln Thr Ala  Arg Val Cys Ala Phe  Glu Gln Thr 
    1055                 1060                 1065             


Leu Glu  Leu Glu Glu Ser Leu  Leu Thr Arg Tyr Pro  His Leu Pro 
    1070                 1075                 1080             


Asp Lys  Asn Phe Arg Lys Met  Leu Glu Ser Trp Ser  Asp Pro Leu 
    1085                 1090                 1095             


Leu Ala  Lys Trp Pro Glu Leu  His Glu Lys Val Arg  Leu Leu Ile 
    1100                 1105                 1110             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1115                 1120                 1125             


Glu Ala  Val Phe Ser Pro Ile  Arg Lys Tyr Asp Pro  Ser Ser Pro 
    1130                 1135                 1140             


Asp Ala  Ile Glu Glu Arg Met  Arg Leu Asn Ile Ala  His Arg Leu 
    1145                 1150                 1155             


Ser Glu  Glu Val Lys Gln Ala  Lys Glu Thr Val Glu  Arg Ile Ile 
    1160                 1165                 1170             


Gln Ala  
    1175 


<210>  2403
<211>  1179
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2403

Met Lys Tyr Pro Ser Ile Ser Asp His Ser Ser Thr Asn Asn Gly Thr 
1               5                   10                  15      


Thr Ala Asp Lys Phe Lys Tyr Pro Lys Gln Leu Asn Leu Ile Leu Lys 
            20                  25                  30          


Lys Ser Leu Leu Ser Glu Lys Glu Leu Leu Pro Leu Trp Ala Ala Tyr 
        35                  40                  45              


Phe Asn Met Ala Arg Tyr Asn Met Tyr Thr Thr Leu Val Tyr Ile Ala 
    50                  55                  60                  


Ala Ser Thr Gly Leu Ser Asp Glu Glu Asn Met Glu Asn Arg Met Asp 
65                  70                  75                  80  


Lys Met Lys Val Leu Asn Ala Pro Val Glu Pro Glu Val Glu Leu Ser 
                85                  90                  95      


Leu Met Lys Leu Leu Cys Arg His Phe Pro Phe Ala Val Trp Ile Cys 
            100                 105                 110         


Ser Ser Gln Thr Ile Lys Lys Met Asn Ser Asn Gly Asp Asn Glu Asp 
        115                 120                 125             


Asn Asn Lys Asn Lys Arg Gly Ile Ser Val Lys Asp Leu Arg Asp Cys 
    130                 135                 140                 


Leu Thr Thr Ile Ser Phe Thr Leu Asn Phe Phe Arg Asn Tyr Tyr Ser 
145                 150                 155                 160 


His Thr Arg His Val Glu Asn Arg Ser Glu Asn Ile Ile Thr Ala Ser 
                165                 170                 175     


Arg Glu Ser Glu Lys Leu Thr Gly Ile Tyr Leu Lys Glu Val Cys Thr 
            180                 185                 190         


Val Ala Thr Arg Ser Val Lys Arg Arg Phe Ser Asp Lys Asn Asn Lys 
        195                 200                 205             


Gly Gln Ala Gly Met Ile Asp Asp Lys Ser Leu Lys Phe Ile Thr Glu 
    210                 215                 220                 


Gln Lys Gly Arg Val Ser Thr Ile Asp Gly Glu Asn Gln Phe Val Ser 
225                 230                 235                 240 


Asn Pro Asp Tyr Phe Leu Asn Pro Leu Val Leu Val Asn Glu Asp Ile 
                245                 250                 255     


Leu Gln Asn Gly Ala Asn Pro Glu Arg Leu Ser Thr Val Gly Lys Ile 
            260                 265                 270         


Gln Leu Ile Cys Leu Leu Leu Asp Lys Lys Tyr Ile Thr Glu Phe Leu 
        275                 280                 285             


Thr Gln Ser Gly Phe Leu Asn Ala Phe Asp Asn Asn Ser Asp Ala Pro 
    290                 295                 300                 


Lys Leu Ser Asp Arg Arg Leu Ile Leu Glu Val Leu Ser Asp Leu Arg 
305                 310                 315                 320 


Ile Arg Met Pro Lys Lys Lys Ile Asp Ser Thr Arg Asn Asp Ile Gln 
                325                 330                 335     


Val Ala Leu Asp Met Leu Asn Glu Leu Lys Lys Cys Pro Asn Glu Leu 
            340                 345                 350         


Phe Asp Leu Leu Ser Pro Glu Asp Lys Ala Thr Phe Ser Ile Glu Ser 
        355                 360                 365             


Ser Thr Gly Glu Thr Ile Leu Leu Arg Arg Ser Ser Asp Arg Phe Thr 
    370                 375                 380                 


Pro Leu Val Leu Gln Trp Phe Asp Ala Asn Lys Thr Phe Lys Lys Ile 
385                 390                 395                 400 


Arg Phe Gln Val Asn Ala Gly Val Phe Arg Tyr Leu Phe Asn Asp Ser 
                405                 410                 415     


Lys Thr Cys Ile Asp Gly Lys Thr Arg Leu Arg Val Leu Gln Glu Pro 
            420                 425                 430         


Leu Asn Cys Phe Gly Arg Leu Gln Glu Val Glu Asp Lys Arg Glu Ser 
        435                 440                 445             


Asn Arg Asp Gly His Asp Gly Pro Trp Lys Gly Phe Cys Ile Lys Gly 
    450                 455                 460                 


Phe Asp Glu Ala Ala Arg Asn Asp Ile Asn Cys Leu Pro Tyr Ile Asn 
465                 470                 475                 480 


Asp Ala Arg Thr Arg Tyr Ile Ile Asn Thr Asp Thr Ile Ala Ile Arg 
                485                 490                 495     


Phe Gly Glu Asn Asp Glu Val Cys Gly Asp Tyr Val Pro Thr Ile Glu 
            500                 505                 510         


Lys Lys Asp Ser Ser Tyr Asn Val Ala Cys Leu Pro Ala Gln Cys Met 
        515                 520                 525             


Met Ser Ile Tyr Glu Leu Gln Ala Met Leu Phe Leu His Leu Leu Asn 
    530                 535                 540                 


Pro Gly Lys Glu Gly Glu Thr Ala Pro Val Glu Lys Ile Ile Ile Asp 
545                 550                 555                 560 


Lys Val Glu Ser Tyr Arg Arg Phe Phe Ser Asp Ile Lys Asn Gly Arg 
                565                 570                 575     


Leu Thr Pro Ser Gly Gln Thr Lys Asp Leu Leu Asn Lys Lys Leu Ile 
            580                 585                 590         


Ser Asp Tyr Gly Ile Gln Leu Ser Asp Thr Pro Asp Lys Met Lys Asp 
        595                 600                 605             


Tyr Leu Leu Gly Lys Val His Glu Gly Arg Gly Phe Lys Ala Tyr Arg 
    610                 615                 620                 


Ser Arg Leu Ile Glu Thr Leu Lys Glu Glu Thr Glu Tyr Lys Ile Asn 
625                 630                 635                 640 


Arg Phe Asn Asn Asp Cys Glu Ala Val Glu Ser Asp Thr Asn Lys Pro 
                645                 650                 655     


Gly Lys Ser Gly Tyr Val Leu Ile Lys Pro Gly Ser Leu Ala Ser Phe 
            660                 665                 670         


Ile Ser Lys Asp Ile Val Phe Phe Gln Glu Gly Asn Ala Asp Gln Lys 
        675                 680                 685             


Met Thr Gly Leu Asn Phe Ser Val Met Gln Gly Leu Ile Ala Thr Phe 
    690                 695                 700                 


Gly Ser Pro Glu Gly Ala Thr Thr Asp Asp Leu Arg Met Ala Phe Cys 
705                 710                 715                 720 


Asn Ser Gly Leu Ile Lys Thr Asn Gly Val Cys Gly Thr His Pro Phe 
                725                 730                 735     


Leu Ala Thr Ala Phe Asn Ala Gly Val Lys Asn Thr Thr Asp Leu Tyr 
            740                 745                 750         


Lys Glu Tyr Leu Lys Ala Arg Lys Ala Tyr Leu Ser Gly Met Val Pro 
        755                 760                 765             


Asp Asn Arg Ser Ile Leu Val Leu His Ser Asp Arg Lys Arg Trp Ala 
    770                 775                 780                 


Val Arg Asp Asp Asp Tyr Tyr Lys Glu Tyr Ala Glu Arg Cys Leu His 
785                 790                 795                 800 


Arg Pro Ile Leu Leu Pro Arg Arg Leu Phe Glu Ser Ser Ile Arg Glu 
                805                 810                 815     


Asn Leu Leu Asp Leu Lys Gly Ile Tyr Ala Gly Lys Leu Lys Glu Val 
            820                 825                 830         


Ile Arg Glu Ala Gly Glu Arg Cys Asn Ser Ala Tyr Met Ile Asp Ser 
        835                 840                 845             


Tyr Phe Tyr His Ile Lys Asp Asp Cys Pro Gln Thr Phe His Gly Thr 
    850                 855                 860                 


Cys Glu Gly Asp Met Val His Thr Tyr Gly His Arg Phe Phe Gln Val 
865                 870                 875                 880 


Val Arg Lys His Phe Asp Asn Ala Lys Ala Ile Leu Ser Asp Leu Lys 
                885                 890                 895     


Lys Asp Ser Lys Thr His Ser Thr Tyr Ile Lys Glu Leu Ser Glu Ala 
            900                 905                 910         


Ile Lys Trp Ala Lys Lys Asp Ile Ile Thr Gln Ser Thr Ser Ser Lys 
        915                 920                 925             


Glu Arg Thr Lys Glu Glu Val Ala Ile Met Ile Lys Arg Ala Phe Asn 
    930                 935                 940                 


Glu Tyr Thr Ala Thr Glu Lys Thr Leu Arg Arg Tyr Val Val Gln Asp 
945                 950                 955                 960 


Glu Leu Leu Phe Leu Ala Ala Met Lys Thr Ile Lys Gly Met Phe Asn 
                965                 970                 975     


Ile Asn Glu Ser Glu Trp Lys Leu Gly Asn Leu Gly Pro Lys Thr Asp 
            980                 985                 990         


Gly Ser Ile Leu Asp Lys Glu Leu  Pro Ser Ile Lys Thr  Pro Ala Lys 
        995                 1000                 1005             


Phe Ile  Ile Lys Thr Asp Ser  Val Ala Phe Val Ile  Glu Gln Arg 
    1010                 1015                 1020             


Asn Val  Asn Ile Lys Asp Tyr  Gly Glu Ile Tyr Arg  Ile Leu Ala 
    1025                 1030                 1035             


Asp Glu  Arg Leu Tyr Gly Leu  Leu Lys Tyr His Gln  Asn Glu Thr 
    1040                 1045                 1050             


Val Leu  Ala Ser Asp Leu Lys  Ser Glu Ile Glu Glu  Tyr Asp Arg 
    1055                 1060                 1065             


Gln Arg  Val Asn Val Phe Lys  Asp Ile Met Glu Tyr  Glu Lys Lys 
    1070                 1075                 1080             


Ile Thr  Arg Asn Val Asp Asp  Ser Gln Leu Cys Glu  Ile Arg Asn 
    1085                 1090                 1095             


Lys Leu  Asn Leu Lys Asp Ile  Asp Phe Lys Val Met  Gln Thr Phe 
    1100                 1105                 1110             


Asp Thr  Met Asn Asp Asn Leu  Thr Lys Met Glu Ile  Arg Ser Ile 
    1115                 1120                 1125             


Arg Asn  Ala Phe Cys His Asn  Ser Tyr Pro Glu Lys  Asn Ala Val 
    1130                 1135                 1140             


Asp Asn  Lys Ser Lys Lys Glu  Arg Arg Met His Asp  Ala Asp Leu 
    1145                 1150                 1155             


Pro Gly  Thr Ala Lys Lys Ile  Ser Arg Arg Ile Asn  Asp Ile Ser 
    1160                 1165                 1170             


Leu Glu  Thr Lys Ser Lys 
    1175                 


<210>  2404
<211>  1119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2404

Met Asp Glu Asn Ile Asn Tyr Tyr Asp Phe Asn Asn Ile Glu Asp Lys 
1               5                   10                  15      


His Phe Phe Ala Gly Tyr Tyr Asn Leu Ala Asn Asp Asn Phe Tyr Asn 
            20                  25                  30          


Val Leu Lys Glu Leu Lys Tyr Ile Ser Asp Lys Lys Leu Asp Ile Thr 
        35                  40                  45              


Glu Ile Asn Lys Ala Ser Tyr Ser Glu Leu Asp Thr Arg Leu Asn Lys 
    50                  55                  60                  


Leu Gln Arg Phe Leu Pro Phe Ile Pro Ser Leu Val Val Asp Lys Glu 
65                  70                  75                  80  


Ile Lys Asp Gln Lys Phe Glu Ile Thr Thr Leu Leu Lys Phe Leu Trp 
                85                  90                  95      


Ser Glu Ile Glu Lys Gln Arg Asn Phe Tyr Thr His Tyr Ala His Asn 
            100                 105                 110         


Arg Pro Glu Phe Ile Leu Glu Ser Asn Gln Gln Ile Leu Asn His Tyr 
        115                 120                 125             


Phe Ile Lys Ala Val Glu Leu Ile Lys Lys Ser Val Lys Asp Glu Leu 
    130                 135                 140                 


Cys Arg Asn Ser Ile Arg Glu His Phe Ser Val Glu Phe Asn Glu Leu 
145                 150                 155                 160 


Lys Val Leu Gln Lys Arg Tyr Ile Glu Glu Lys Ile Arg Asn Ser Lys 
                165                 170                 175     


Ser Asn Ser Glu Lys Lys Lys Tyr Ser Leu Asp Glu Glu Ser Ile Asn 
            180                 185                 190         


Asn Gly Ile Phe Asn Lys Leu Phe Lys Pro Tyr Ile Ile Lys Asp Lys 
        195                 200                 205             


Val Thr Gly Ile Leu Ser Ile Asn Asn Tyr Arg Leu Leu Phe Asp Ser 
    210                 215                 220                 


Ser Gly Tyr Leu Thr Lys His Gly His Leu Phe Leu Leu Ser Leu Phe 
225                 230                 235                 240 


Leu Lys Arg Asp Gln Met Glu Ser Leu Met Asp Lys Ile Glu Gly Tyr 
                245                 250                 255     


Lys Ala Ser His Lys Leu Tyr Phe His Leu Thr Arg Arg Ile Tyr Ser 
            260                 265                 270         


His Phe Cys Phe Lys Gly Ile Lys Arg Gln Ile Val Ser Gln His Ser 
        275                 280                 285             


Lys Thr Lys Leu Met Leu Gln Met Ala Asp Glu Leu Gly Lys Ile Pro 
    290                 295                 300                 


Glu Glu Leu Tyr Asn Leu Leu Asn Asn Asn Glu Lys Ala Glu Phe Ile 
305                 310                 315                 320 


Val Asp Ile Asn Glu Tyr Tyr Lys Asp Asn Asp Gln Asn Gly Glu Asn 
                325                 330                 335     


Pro Asp Glu Lys Arg Val Ile His Asp Val Val Arg Arg Arg Tyr Lys 
            340                 345                 350         


Gln Thr Asp Lys Ser Phe Ser Asp Thr Tyr Gly Thr Asn Lys Thr Ile 
        355                 360                 365             


Asp Lys Phe Glu Tyr Phe Ala Leu Arg Phe Phe Asp Glu Asp Ser Lys 
    370                 375                 380                 


Leu Lys Asn Ile Lys Phe Met Ile Asp Trp Gly Asn Val Ile Ile Asp 
385                 390                 395                 400 


Lys Arg Ser Lys Asn Ile Leu Asp Met Gln Thr Glu Arg Ile Ile Lys 
                405                 410                 415     


Lys Arg Val Thr Val Phe Glu Asn Ile Asn Thr Val Ile Asp Lys Lys 
            420                 425                 430         


Ile Glu Leu Val Asn Ser Asn Asn Cys Asn Gly Gln Ile Leu Ile Asp 
        435                 440                 445             


Glu Glu Asn Ser Thr Cys Leu Ile Glu Gly Tyr Pro Phe Pro Ala Asn 
    450                 455                 460                 


Pro Ser Tyr Tyr Phe Gln Gly His Asn Ile Pro Ile Tyr Leu Ser Tyr 
465                 470                 475                 480 


Asn Asn Lys Lys Glu Ala Asp Cys Glu Asp Thr Glu Ile Asn Lys Val 
                485                 490                 495     


Arg Asn Ala Val Leu Lys Asn Thr Leu Gly Asp Asn Val Phe Pro Asn 
            500                 505                 510         


Lys Pro Asn Ala Leu Leu Ser Leu Tyr Glu Leu Pro Ala Met Leu His 
        515                 520                 525             


Val Tyr Phe Asn His Ala Asn Lys Glu Lys Glu Val Phe Lys Leu Leu 
    530                 535                 540                 


Ile Asn Lys Tyr Phe Lys Tyr Lys Lys Asp Leu Asn Phe Lys Glu Asn 
545                 550                 555                 560 


Ile Asn Asp Asn Gln Leu Val His Leu Lys Lys Ile Lys Asn Asn Lys 
                565                 570                 575     


Ile Leu Leu Glu Lys Asn Glu Tyr Thr Phe Asn Arg Gln Lys Leu Val 
            580                 585                 590         


Ser Asp Ile Asn Lys Glu Ile Ile Lys Thr Glu Ile Lys Ile Asn Glu 
        595                 600                 605             


Phe Asn Lys Cys Lys Leu Glu Tyr His Asp Ile Lys Asn Lys Arg Lys 
    610                 615                 620                 


Tyr Leu Met Tyr Asn Ser Glu Lys Gly Leu Val Ala Thr Phe Leu Ala 
625                 630                 635                 640 


Asp Glu Ile Leu Arg Trp Met Pro Arg Asn Leu Lys Glu Asn Trp Lys 
                645                 650                 655     


Gly Tyr His His Ser Glu Leu Gln Lys Leu Leu Ser Phe Phe Gln Ile 
            660                 665                 670         


Glu Lys Asn Asn Ile Asn His Leu Ile Ile Phe Asp Asp Lys Phe Asp 
        675                 680                 685             


Phe Leu Arg Asp Ile Phe Lys Lys Ser Asn Ser Leu Glu Asp Leu Tyr 
    690                 695                 700                 


Ile Asn Tyr Leu Asn Gly Lys Ile Glu Lys Leu Lys Ser Phe Leu Ser 
705                 710                 715                 720 


Ile Leu Asp Ile Lys Glu Lys Lys Val Leu Lys Lys Gly Leu Cys Asp 
                725                 730                 735     


Ile Trp Val Phe Phe Lys Gln Ser Lys Tyr Asn Ile Lys Asn Ile Asn 
            740                 745                 750         


Ser Tyr Ser Glu Glu Leu Leu Lys Lys Pro Ile Leu Leu Gly Arg Gly 
        755                 760                 765             


Ile Phe Asp Asp Thr Pro Thr Phe Tyr Pro Ser Asp Leu Lys Asp Asn 
    770                 775                 780                 


Pro Lys Ala Asn Trp Phe Glu Thr Val Lys Lys Asn Gln Ser Tyr Gln 
785                 790                 795                 800 


Ser Phe Tyr Asn Leu Leu Glu Asp Lys Leu Lys Pro Val Ser Gly Glu 
                805                 810                 815     


Ser Ser Val Glu Lys Arg Arg Arg Ile Glu Lys Tyr Arg Ser Ile Glu 
            820                 825                 830         


Tyr Gln Lys Ile Lys Asp Ile Tyr Thr Leu Glu Met Phe Lys His Leu 
        835                 840                 845             


Tyr Lys Glu Ile Phe Gly Asn Glu Glu Ile Met Glu Asn Ile Thr Leu 
    850                 855                 860                 


Thr Asp Phe Tyr Gln Ser Pro Ala Glu Arg Lys Lys Met Ile Ala Asn 
865                 870                 875                 880 


Ala Ser Ser Gln Asn Asn Arg Asn Gln Gly Asn Cys Ser Lys Asn Lys 
                885                 890                 895     


Tyr Asn Glu Leu Gly Ile Trp Asn Lys Val Thr Pro Cys Asn Phe Glu 
            900                 905                 910         


Asn Gly Arg Val Val Ala Pro Gln Ile Lys Leu Lys Glu Ile Gly Lys 
        915                 920                 925             


Phe Glu Gln Leu Leu Leu Asp Asp Lys Val Lys Ala Ile Leu Ser Tyr 
    930                 935                 940                 


Asn Asp Gln Ile Trp Gln Lys Gln Glu Leu Glu Arg Glu Leu Glu Ser 
945                 950                 955                 960 


Tyr Arg Ile Val Arg Glu Glu Lys Leu Phe Lys Ile Ile His Asn Leu 
                965                 970                 975     


Glu Lys Val Ile Leu Glu Ile Glu Thr Leu His Arg Glu Asp Lys Ser 
            980                 985                 990         


His Pro Ile Ile Phe Asn Asn Gly  Glu Tyr Pro Asn Phe  Arg Lys Tyr 
        995                 1000                 1005             


Ile Glu  Asn Ser Lys Ile Phe  Asn Trp Ser Gln Glu  Asp Lys Asn 
    1010                 1015                 1020             


Ile Ile  Asn Cys Phe Asn Ser  Glu Leu Leu Glu Asn  Ser Phe Pro 
    1025                 1030                 1035             


Glu Ile  Ile Val Asn Ala Asn  Pro Arg Leu Gln Lys  Ala Ile Leu 
    1040                 1045                 1050             


Leu Ile  Tyr Ile Arg Asn Lys  Phe Ala His Asn Gln  Leu Pro Ser 
    1055                 1060                 1065             


Lys His  Val His Asn Phe Cys  Lys Lys Ile Ser Cys  Ile Asn Asp 
    1070                 1075                 1080             


Glu Arg  Val Thr Thr Tyr Ala  Glu Phe Tyr Leu Met  Ile Val Glu 
    1085                 1090                 1095             


Asn Phe  Ile Leu Asp Gln Asn  Phe Ile Lys Thr Lys  Gln Val Tyr 
    1100                 1105                 1110             


Asn Asn  Asn Ser Ile Ser 
    1115                 


<210>  2405
<211>  1165
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2405

Met Lys Lys Thr Asn Ala Glu Glu Ser Asn Phe Asn His Thr Leu Asn 
1               5                   10                  15      


Asp Gln Lys Tyr Tyr Phe Ala Gly Tyr Leu Asn Leu Ala Glu Asn Asn 
            20                  25                  30          


Ile Lys Thr Leu Glu Lys Ala Tyr Gly Glu His Phe Leu Cys Ser Gly 
        35                  40                  45              


Lys Glu Thr Ile Ile Ser Asn Leu Asn Asn Thr Ser Ser Leu Ile Asp 
    50                  55                  60                  


Trp Asp Leu Lys Val Lys Phe Leu Ser Gln Tyr Leu Pro Val Val Ser 
65                  70                  75                  80  


Tyr Leu Asn Leu Asp Thr Asp Pro Asn Ser Thr Phe Lys Ile Ile Lys 
                85                  90                  95      


Lys Glu Phe Ser Glu Asn Leu Ser Ser Leu Phe Asp Ser Ile Gly Ser 
            100                 105                 110         


Leu Arg Asn Phe Tyr Ser His Tyr Tyr His Arg Pro Leu Thr Glu Glu 
        115                 120                 125             


Leu Asn Ile Glu Leu Leu Ser Phe Leu Asp Arg Thr Phe Val Ala Val 
    130                 135                 140                 


Cys Ile Asn Val Lys Lys Lys Arg Met Lys Asp Asp Lys Thr Lys Gln 
145                 150                 155                 160 


Leu Leu Lys Ala Thr Leu Asn Asn Glu Leu Asp Leu Leu Leu Lys Ala 
                165                 170                 175     


Lys Lys Glu Glu Leu Leu Lys Lys Lys Lys Glu Gly Lys Lys Val Ser 
            180                 185                 190         


Ile Asp Ala Ile Ser Met Lys Asn Ser Val Leu Asn Asp Ala Phe Asn 
        195                 200                 205             


His Leu Val Gln Leu Asp Lys Asn Ser Arg Glu Glu Ile Pro Gly Arg 
    210                 215                 220                 


Phe Tyr Thr Ser Val Leu Gly Asp Asn Asn Lys Tyr Thr Glu Asn Glu 
225                 230                 235                 240 


Ile Asn Ile Ser Met Ser Gly Leu Leu Phe Leu Leu Ser Met Phe Leu 
                245                 250                 255     


Thr Lys Lys Gln Asn Glu Asp Met Arg Ser Arg Ile Phe Gly Phe Lys 
            260                 265                 270         


Gly Thr Ile Asp Pro Asp Lys Ser Ile Ser Lys Ser Asn Asn Ser Phe 
        275                 280                 285             


Arg Asn Met Ala Thr Asn Trp Val Phe Ser Tyr Leu Ser Phe Lys Gly 
    290                 295                 300                 


Met Lys Lys Gln Leu Gly Asn Thr Phe Lys Lys Glu Ser Leu Leu Val 
305                 310                 315                 320 


Gln Ile Val Asp Glu Leu Ser Lys Val Pro His Glu Val Tyr Gln Thr 
                325                 330                 335     


Leu Ser Pro His His Gln Glu Met Phe Leu Glu Asp Met Asn Glu Tyr 
            340                 345                 350         


Leu Lys Glu Gly Asn Lys Lys Leu Cys Leu Glu Asp Ser Ile Val Val 
        355                 360                 365             


His Pro Val Ile Arg Lys Arg Tyr Glu Asp Lys Phe Asn Tyr Phe Ala 
    370                 375                 380                 


Ile Arg Tyr Leu Asp Glu Phe Val Glu Phe Pro Ser Leu Arg Phe Gln 
385                 390                 395                 400 


Val Asn Val Gly Asn Tyr Val His Asp Arg Arg Met Lys Thr Ile Asp 
                405                 410                 415     


Gly Thr Lys Thr Glu Thr Asp Arg Met Val Lys Glu Glu Ile Arg Ala 
            420                 425                 430         


Phe Gly Lys Leu Ser Val Ile Ser Lys Leu Lys Ala Asp Phe Phe Ala 
        435                 440                 445             


Lys Asp Leu Pro Ser Asp Ile Ser Trp Glu Met Tyr Pro Asn Pro Ser 
    450                 455                 460                 


Tyr Asn Ile Ser Ala Asn Asn Ile Pro Val Tyr Ile Asp Leu Ile Lys 
465                 470                 475                 480 


Ser Ser Val Ala Gly Ala Val Asp Val Gly Lys Asp His Lys Ser Tyr 
                485                 490                 495     


Gln Ala Lys Leu Asp Leu Asp Glu Asp Lys Arg Lys Arg Asn Arg Lys 
            500                 505                 510         


Glu Gly Lys Pro Gly Lys Thr Glu Ile Ala Arg Ile Leu Leu Gly Lys 
        515                 520                 525             


Lys Gln Ile Leu Phe Glu Lys Pro Thr Val Leu Leu Ser Leu Asn Glu 
    530                 535                 540                 


Leu Pro Ala Leu Leu Tyr Glu Val Leu Lys Glu Gly Gly Asp Lys Gln 
545                 550                 555                 560 


Asp Ile Gly Lys Arg Ile Glu Asp Lys Ile Val Glu Lys Ile Val Ala 
                565                 570                 575     


Gln Tyr Lys Leu Ile Asp Gln Tyr Asp Gly Thr Ile Glu Leu Pro Gly 
            580                 585                 590         


Ser Val Ile Pro Lys Lys Leu Arg Lys Ser Gly Ser Glu Lys Cys Thr 
        595                 600                 605             


Asn Met Asp Lys Leu Leu Arg Ala Val Lys Arg Glu Leu Glu Ile Thr 
    610                 615                 620                 


Gln Glu Lys Leu Asp Leu Ile Lys Asn Asn Lys Lys Lys Phe Glu Ser 
625                 630                 635                 640 


Lys Glu Lys Asp Glu Lys Gly Lys Ala Arg Gln His Val Phe Tyr Thr 
                645                 650                 655     


Asn Glu Leu Gly Gln Glu Ala Thr Trp Ile Ala Asn Asp Ile Lys Arg 
            660                 665                 670         


Phe Met Pro Arg Asp Val Lys Glu Lys Trp Arg Gly Tyr His His Ser 
        675                 680                 685             


Asn Leu Gln Lys Leu Leu Ser Gln Tyr Asn Gln Ser Arg Asn Glu Ala 
    690                 695                 700                 


Val Lys Cys Ile Thr Cys Phe Trp Asn Phe Asp Gln Gln Thr Pro Trp 
705                 710                 715                 720 


Gly Lys Gly Ile Lys Glu Ala Phe Tyr Lys Ser Thr Phe Glu Glu Phe 
                725                 730                 735     


Tyr Lys Ala Tyr Leu Asp Asn Arg Met Asp Val Tyr Lys Thr Leu Glu 
            740                 745                 750         


Asn Asn Leu Ile Ala Ala Lys Gly His Ser Lys Leu Phe Asn Lys Glu 
        755                 760                 765             


Lys Lys Lys Ala Phe Val Leu Phe Asp Lys His Leu Tyr Asn Ile Pro 
    770                 775                 780                 


Asp Ile Asn Thr Gln Lys Glu Arg Leu Lys Ser Thr Leu Phe Ile Leu 
785                 790                 795                 800 


Pro Arg Gly Ile Phe Asp Ser Lys Pro Thr Phe Ile Lys Gly Ile Lys 
                805                 810                 815     


Tyr Glu Glu Asp Pro Ser Cys Phe Ala Asp Trp Tyr Gln Phe Ala Asn 
            820                 825                 830         


Asn Ala Gly Asn Glu Tyr Gln Gln Phe Tyr Asn Leu Thr Arg Ser Tyr 
        835                 840                 845             


Thr Ser Leu Phe Glu Glu Thr Lys Lys Asn Asn Glu Gly Leu Lys Glu 
    850                 855                 860                 


Asn Lys Lys Gly Leu Ser Ala Asp Glu Gln Phe Asp Phe Phe Lys Met 
865                 870                 875                 880 


Arg Gln Asp Leu Lys Ile Lys Lys Ile Lys Thr Gln Asp Leu Phe Leu 
                885                 890                 895     


Phe Gln Ile Val Lys Asp Leu Tyr Lys Lys Val Phe Gly Arg Thr Phe 
            900                 905                 910         


Pro Glu Gly Leu Glu Leu Lys Asp Met Tyr Gln Thr Pro Ala Glu Arg 
        915                 920                 925             


Gln Ala Asn Tyr Glu Leu Ala Val Lys Gln Ser Gln Arg Thr Glu Gly 
    930                 935                 940                 


Asp Lys Ser Asp Asn Leu Tyr Asn Thr Asn Phe Leu Trp Asn Leu Thr 
945                 950                 955                 960 


Val Pro Phe Glu Thr Gly Lys Ile Lys Glu Pro Gln Val Lys Leu Lys 
                965                 970                 975     


Asp Ile Gly Lys Phe Tyr Lys Phe Ala Ala Asp Glu Lys Val Gln Thr 
            980                 985                 990         


Ile Leu Ser Tyr Ser Asp Arg Glu  Trp Ser Lys Leu Asp  Leu Glu Lys 
        995                 1000                 1005             


Glu Leu  Glu Leu Met Pro Thr  Ser Tyr Glu Val Ile  Arg Arg Glu 
    1010                 1015                 1020             


Gln Leu  Leu Arg Asp Ile Gln  Gln Phe Glu Lys Arg  Ile Leu Glu 
    1025                 1030                 1035             


Asn Tyr  Pro Ser Asp Gly Asn  Ala His Pro Arg Asp  Phe Glu Ile 
    1040                 1045                 1050             


Val Arg  Asn Gly Ile Leu Ser  Pro Ser Phe Asn Phe  Tyr Leu Leu 
    1055                 1060                 1065             


Lys Gly  Val Ile Ile Lys Asn  Asn Leu Ala Ser Glu  Glu Glu Cys 
    1070                 1075                 1080             


Gln Trp  Phe Glu Gln Val His  Leu Asn Lys Thr Gln  Phe Tyr Pro 
    1085                 1090                 1095             


Glu Val  Ala Thr Lys Ser Thr  Ile Ile Gln Ser Ala  Tyr Leu Leu 
    1100                 1105                 1110             


Leu Leu  Ile Arg Asn Lys Met  Leu His Asn Gln Leu  Pro Ser Lys 
    1115                 1120                 1125             


Gln Asn  Phe Glu Phe Met Thr  Thr Leu Tyr Pro Phe  Gln Gly Tyr 
    1130                 1135                 1140             


Glu Asn  Tyr Ser Thr Tyr Leu  Leu Ser Val Thr Lys  Gln Thr Ile 
    1145                 1150                 1155             


Glu Cys  Leu Ser Ser Ala Met  
    1160                 1165 


<210>  2406
<211>  957
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (31)..(40)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (197)..(836)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (885)..(898)
<223>  Xaa can be any naturally occurring amino acid

<400>  2406

Met Arg Asn Ile Cys Ser Ser Arg Phe Ser Ser Val Cys Ser Thr Ser 
1               5                   10                  15      


Pro Arg Asp Ala Tyr Ala Ile Val Thr Pro Ala Thr Met His Xaa Xaa 
            20                  25                  30          


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Asp Val Glu Pro Asn Leu Pro 
        35                  40                  45              


Ile Gly Val Leu Glu Asn Phe Lys Tyr Ser Glu Gln Gln Thr Ala Ile 
    50                  55                  60                  


Pro Ser Ser Thr Thr Ile Leu Leu Tyr Thr Asp Gly Val Thr Glu Ala 
65                  70                  75                  80  


Val Asn Ala Asn Asn Asn Leu Tyr Gly Ile Asp Arg Leu Lys Arg Ile 
                85                  90                  95      


Cys Ser Asn Thr Ser Ala Pro Lys Glu Leu Val Ser Lys Ile Lys Asn 
            100                 105                 110         


Asp Ile Glu Leu Phe Ala Asn Lys Thr Glu Gln Ser Asp Asp Ile Thr 
        115                 120                 125             


Met Leu Ala Ile Arg Phe Thr Leu Asn Asp Asp Thr Asp Ser Glu Glu 
    130                 135                 140                 


Ile Ser Val Glu Met Thr Ser Asp Ile Asn Gln Ile Thr Arg Leu Glu 
145                 150                 155                 160 


Gly Leu Cys Asn Ser Leu Arg Asp Lys Phe Ser Ile Glu Gln Gln Leu 
                165                 170                 175     


Ala Thr Arg Leu Asn Val Ala Leu Glu Glu Ala Val Ser Asn Val Ile 
            180                 185                 190         


Leu Tyr Gly Phe Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        195                 200                 205             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    210                 215                 220                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                245                 250                 255     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
305                 310                 315                 320 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                325                 330                 335     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            340                 345                 350         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        355                 360                 365             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
385                 390                 395                 400 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                405                 410                 415     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            420                 425                 430         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        435                 440                 445             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    450                 455                 460                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
465                 470                 475                 480 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                485                 490                 495     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            500                 505                 510         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        515                 520                 525             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    530                 535                 540                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
545                 550                 555                 560 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                565                 570                 575     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            580                 585                 590         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        595                 600                 605             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    610                 615                 620                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
625                 630                 635                 640 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                645                 650                 655     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            660                 665                 670         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        675                 680                 685             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    690                 695                 700                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
705                 710                 715                 720 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                725                 730                 735     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            740                 745                 750         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        755                 760                 765             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    770                 775                 780                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
785                 790                 795                 800 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                805                 810                 815     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            820                 825                 830         


Xaa Xaa Xaa Xaa Tyr Arg Ile Leu Thr Pro Arg Pro Arg Val Glu Ser 
        835                 840                 845             


Thr Arg Pro Glu Tyr Ala Leu Ala Leu Asp Ile Phe Asn Glu Leu Gln 
    850                 855                 860                 


Lys Ala Pro Ile Glu Leu Phe Asp Thr Phe Ser Pro Asp Asp Gln Ala 
865                 870                 875                 880 


Lys Phe Arg Ile Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                885                 890                 895     


Xaa Xaa Leu Trp Cys Asp Ile Val Thr Ala Phe His Ile Leu Ser Cys 
            900                 905                 910         


Asp Ile Leu Met Thr Thr Val Phe Ser Arg Lys Ser Ala Phe Lys Cys 
        915                 920                 925             


Arg Leu Glu Asn Thr Val Ser Asn Ser Thr Lys Ser Asn Ala Leu Thr 
    930                 935                 940                 


Leu Pro Ile Lys Thr Ala Ser Val Arg Tyr Lys Lys Lys 
945                 950                 955         


<210>  2407
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2407

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Ala Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Asn Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2408
<211>  994
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2408

Met Gly Ala Ile Lys Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Ile Leu Gln Gly Lys 
    610                 615                 620                 


Leu Asn Ile Gln Cys His Pro Leu Arg Asp Leu Gln Arg Glu Pro Asn 
625                 630                 635                 640 


Lys Pro Gln Asp Lys Glu Glu Ala Ile Phe Leu Pro Arg Gly Leu Phe 
                645                 650                 655     


Asn Glu Ala Ile Ile Asn Cys Leu Lys Lys Ser Lys Leu Lys Gln Leu 
            660                 665                 670         


Ile Glu Ser Pro Thr Arg Glu Lys Ser Pro Ala Leu Asn Val Ser Tyr 
        675                 680                 685             


Leu Ile Gln Asn Tyr Phe Arg Thr Tyr Phe Glu Asp Gln Ser Gln Glu 
    690                 695                 700                 


Phe Tyr Ala Gln Pro Arg Asn Tyr Arg Leu Phe Asp Lys Leu Ser Pro 
705                 710                 715                 720 


Asn Lys Gly Lys Ser Lys Ser Tyr Leu Ser Leu Glu Gln Arg Ile Lys 
                725                 730                 735     


Lys Met Glu Glu Leu Arg Pro Ser Lys Ile Pro Val Ala Glu Ala Asn 
            740                 745                 750         


Lys Leu Leu Glu Lys Glu Asp Arg Leu Tyr Arg Lys Asn Tyr Asn Glu 
        755                 760                 765             


Ile Cys Asp Asn Glu Ser Ile Ile Arg Leu Tyr Gln Ile Gln Asp Ile 
    770                 775                 780                 


Leu Leu Phe Met Met Thr Lys Glu Tyr Leu Pro Ser Asp Leu Tyr Asn 
785                 790                 795                 800 


Arg Ile Asn Lys Tyr Lys Leu Glu Asn Val Lys Gly Ile Leu Asn Glu 
                805                 810                 815     


Arg Val Ser Tyr Leu Ile Asp Leu Asn Pro Leu Lys Ile Gln Gly Glu 
            820                 825                 830         


Asp Ile Lys Ile Lys Asp Tyr Gly Lys Leu Phe Tyr Ile His His Asp 
        835                 840                 845             


Thr Arg Ile Ser Ser Leu Asn Lys Val Leu Ser Lys Val Lys Arg Asn 
    850                 855                 860                 


Asn Ser Ile Ser Ser Ser Val Lys Ile Gln Pro Tyr Glu Asn Tyr Lys 
865                 870                 875                 880 


Arg Glu Cys Leu Asp Phe Glu Glu Ala Gln Ile Gln Ile Ile Pro Ile 
                885                 890                 895     


Ile His Ser Phe Glu Ile Ala Met Val Ser Met Phe Pro Asp Leu Lys 
            900                 905                 910         


Lys Ala Thr Pro Gly Asn Tyr Tyr Asp Phe Asn Glu Leu Ile Thr Glu 
        915                 920                 925             


Tyr Glu Lys Arg Thr Lys Gln Lys Ile Asp Ser Ser Phe Leu Ile Lys 
    930                 935                 940                 


Thr Arg Asn Met Phe Leu His Asp Lys Tyr Glu Ala Glu Cys Ile Lys 
945                 950                 955                 960 


Glu Ile Ser Asp Asp Phe Val Tyr Ala Lys Lys Ile Ile Ala Glu Phe 
                965                 970                 975     


Lys Met Lys Ile Glu Asn Ile Lys Leu Glu Asp Leu Ser Asn Asp Ser 
            980                 985                 990         


Ser Ala 
        


<210>  2409
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2409

Leu Gln Lys Gln Asp Lys Leu Phe Val Asp Arg Lys Lys Asn Ala Ile 
1               5                   10                  15      


Phe Ala Phe Pro Lys Tyr Ile Thr Ile Met Glu Asn Lys Glu Lys Thr 
            20                  25                  30          


Glu Pro Ile Tyr Tyr Glu Leu Thr Asp Lys His Phe Trp Ala Ala Phe 
        35                  40                  45              


Leu Asn Leu Ala Arg His Asn Val Tyr Thr Thr Val Asn His Ile Asn 
    50                  55                  60                  


Lys Leu Leu Glu Ile Ala Glu Leu Lys Asn Asp Glu Asp Val Leu Asn 
65                  70                  75                  80  


Ile Lys Asp Ser Trp Asn Lys Gln Ala Glu Lys Leu Asp Lys Lys Val 
                85                  90                  95      


Arg Leu Arg Asn Leu Leu Met Arg His Phe Pro Phe Leu Glu Ala Ala 
            100                 105                 110         


Ala Tyr Glu Lys Thr Thr Ser Lys Asp Ser Asn Ser Lys Glu Gln Lys 
        115                 120                 125             


Glu Lys Glu Gln Ala Glu Ala Leu Ser Leu Asp Asn Leu Lys Asn Val 
    130                 135                 140                 


Leu Phe Ile Phe Leu Glu Lys Leu Gln Ser Leu Arg Asn Tyr Tyr Ser 
145                 150                 155                 160 


His Tyr Lys Tyr Ser Glu Glu Ala Gln Lys Pro Thr Phe Glu Asn Asp 
                165                 170                 175     


Leu Leu Lys Asn Met Tyr Lys Ile Phe Asp Thr Asn Val Arg Leu Val 
            180                 185                 190         


Lys Arg Asp Tyr Met His His Glu Asn Val Asp Met Gln Arg Asp Phe 
        195                 200                 205             


Ser His Leu Asn Arg Lys Lys Gln Glu Gly Gln Thr Arg Lys Ile Ile 
    210                 215                 220                 


Ala Asn Pro Asn Phe Arg Tyr His Phe Ala Asp Glu Lys Gly Asp Met 
225                 230                 235                 240 


Thr Ile Ala Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Asp Lys Lys 
                245                 250                 255     


Asp Ala Ile Trp Met Gln Lys Lys Leu Lys Gly Phe Lys Asp Gly Arg 
            260                 265                 270         


Asn Leu Arg Glu Gln Met Thr Asn Glu Val Phe Cys Arg Ser Arg Ile 
        275                 280                 285             


Ser Leu Pro Lys Leu Lys Leu Glu Asn Val Gln Thr Lys Asp Trp Met 
    290                 295                 300                 


Gln Leu Asp Met Leu Asn Glu Leu Val Arg Cys Pro Lys Ser Leu Tyr 
305                 310                 315                 320 


Glu Arg Leu Arg Glu Lys Asp Arg Glu Ser Phe Lys Val Pro Phe Asp 
                325                 330                 335     


Ile Phe Ser Asp Asp Tyr Asp Ala Glu Glu Glu Pro Phe Lys Asn Thr 
            340                 345                 350         


Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe 
        355                 360                 365             


Asp Leu Asn Glu Ile Phe Glu Gln Leu Arg Phe Gln Ile Asp Leu Gly 
    370                 375                 380                 


Thr Tyr His Phe Ser Ile Tyr Asn Lys Arg Ile Gly Asp Glu Asp Glu 
385                 390                 395                 400 


Val Arg His Leu Thr His His Leu Tyr Gly Phe Ala Arg Ile Gln Asp 
                405                 410                 415     


Phe Ala Pro Gln Asn Gln Pro Glu Glu Trp Arg Lys Leu Val Lys Asp 
            420                 425                 430         


Leu Asp His Phe Glu Thr Ser Gln Glu Pro Tyr Ile Ser Lys Thr Ala 
        435                 440                 445             


Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Lys Phe Cys Ser 
    450                 455                 460                 


Thr His Asn Asn Leu Phe Pro Ser Leu Lys Arg Glu Lys Thr Cys Asn 
465                 470                 475                 480 


Gly Arg Ser Lys Phe Asn Leu Gly Thr Gln Phe Thr Ala Glu Ala Phe 
                485                 490                 495     


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu 
            500                 505                 510         


Thr Lys Asp Tyr Ser Arg Lys Glu Ser Ala Asp Lys Val Glu Gly Ile 
        515                 520                 525             


Ile Arg Lys Glu Ile Ser Asn Ile Tyr Ala Ile Tyr Asp Ala Phe Ala 
    530                 535                 540                 


Asn Asn Glu Ile Asn Ser Ile Ala Asp Leu Thr Cys Arg Leu Gln Lys 
545                 550                 555                 560 


Thr Asn Ile Leu Gln Gly His Leu Pro Lys Gln Met Ile Ser Ile Leu 
                565                 570                 575     


Glu Gly Arg Leu Lys Asp Met Glu Lys Glu Ala Glu Arg Lys Ile Gly 
            580                 585                 590         


Glu Met Ile Asp Asp Thr Gln Arg Arg Leu Asp Leu Leu Cys Lys Gln 
        595                 600                 605             


Thr Asn Gln Lys Ile Arg Ile Gly Lys Arg Asn Ala Gly Leu Leu Lys 
    610                 615                 620                 


Ser Gly Lys Ile Ala Asp Trp Leu Val Ser Asp Met Met Arg Phe Gln 
625                 630                 635                 640 


Pro Val Gln Lys Asp Thr Asn Asn Ala Pro Ile Asn Asn Ser Lys Ala 
                645                 650                 655     


Asn Ser Thr Glu Tyr Arg Met Leu Gln His Ala Leu Ala Leu Phe Gly 
            660                 665                 670         


Ser Glu Ser Ser Arg Leu Lys Ala Tyr Phe Arg Gln Met Asn Leu Val 
        675                 680                 685             


Gly Asn Ala Asn Pro His Pro Phe Leu Ala Glu Thr Gln Trp Glu His 
    690                 695                 700                 


Gln Thr Asn Ile Leu Ser Phe Tyr Arg Asn Tyr Leu Glu Ala Arg Lys 
705                 710                 715                 720 


Lys Tyr Leu Lys Gly Leu Lys Pro Gln Asn Trp Lys Gln Tyr Gln His 
                725                 730                 735     


Phe Leu Ile Leu Lys Val Gln Lys Thr Asn Arg Asn Thr Leu Val Thr 
            740                 745                 750         


Gly Trp Lys Asn Ser Phe Asn Leu Pro Arg Gly Ile Phe Thr Gln Pro 
        755                 760                 765             


Ile Arg Glu Trp Phe Glu Lys His Asn Asn Ser Lys Arg Ile Tyr Asp 
    770                 775                 780                 


Gln Ile Leu Ser Phe Asp Arg Val Gly Phe Val Ala Lys Ala Ile Pro 
785                 790                 795                 800 


Leu Tyr Phe Ala Glu Glu Tyr Lys Asp Asn Val Gln Pro Phe Tyr Asp 
                805                 810                 815     


Tyr Pro Phe Asn Ile Gly Asn Lys Leu Lys Pro Gln Lys Gly Gln Phe 
            820                 825                 830         


Leu Asp Lys Lys Glu Arg Val Glu Leu Trp Gln Lys Asn Lys Glu Leu 
        835                 840                 845             


Phe Lys Asn Tyr Pro Ser Glu Lys Lys Lys Thr Asp Leu Ala Tyr Leu 
    850                 855                 860                 


Asp Phe Leu Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys 
865                 870                 875                 880 


Asn Gln Asp Ile Val Thr Trp Leu Met Phe Lys Glu Leu Phe Lys Thr 
                885                 890                 895     


Thr Thr Val Glu Gly Leu Lys Ile Gly Glu Ile His Leu Arg Asp Ile 
            900                 905                 910         


Asp Thr Asn Thr Ala Asn Glu Glu Ser Asn Asn Ile Leu Asn Arg Ile 
        915                 920                 925             


Met Pro Met Lys Leu Pro Val Lys Thr Tyr Glu Thr Asp Asn Lys Gly 
    930                 935                 940                 


Asn Ile Leu Lys Glu Arg Pro Leu Ala Thr Phe Tyr Ile Glu Glu Thr 
945                 950                 955                 960 


Glu Thr Lys Val Leu Lys Gln Gly Asn Phe Lys Val Leu Ala Lys Asp 
                965                 970                 975     


Arg Arg Leu Asn Gly Leu Leu Ser Phe Ala Glu Thr Thr Asp Ile Asp 
            980                 985                 990         


Leu Glu Lys Asn Pro Ile Thr Lys  Leu Ser Val Asp His  Glu Leu Ile 
        995                 1000                 1005             


Lys Tyr  Gln Thr Thr Arg Ile  Ser Ile Phe Glu Met  Thr Leu Gly 
    1010                 1015                 1020             


Leu Glu  Lys Lys Leu Ile Asp  Lys Tyr Ser Thr Leu  Pro Thr Asp 
    1025                 1030                 1035             


Ser Phe  Arg Asn Met Leu Glu  Arg Trp Leu Gln Cys  Lys Ala Asn 
    1040                 1045                 1050             


Arg Pro  Glu Leu Lys Asn Tyr  Val Asn Ser Leu Ile  Ala Val Arg 
    1055                 1060                 1065             


Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met Tyr Asp  Ala Thr Leu 
    1070                 1075                 1080             


Phe Ala  Glu Val Lys Lys Phe  Thr Leu Phe Pro Ser  Val Asp Thr 
    1085                 1090                 1095             


Lys Lys  Ile Glu Leu Asn Ile  Ala Pro Gln Leu Leu  Glu Ile Val 
    1100                 1105                 1110             


Gly Lys  Ala Ile Lys Glu Ile  Glu Lys Ser Glu Asn  Lys Asn 
    1115                 1120                 1125         


<210>  2410
<211>  953
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2410

Met Asn Thr Gln Pro Val Gly Leu Gly Ile Ser Tyr Ser His Thr Ser 
1               5                   10                  15      


Lys Asn Asp Lys His Phe Phe Gly Gly Phe Leu Asn Leu Gly Ile Asn 
            20                  25                  30          


Asn Leu Glu Val Leu Ile Ala Ala Phe Lys Leu Lys Phe Phe Ser Gly 
        35                  40                  45              


Asp Gln Lys Lys Ile Asp Ile Lys Asn Phe Val Gln Thr Cys Phe Thr 
    50                  55                  60                  


Ala Asn Ile Ser Asp His Asp Phe Glu Ser Arg Val Glu Phe Leu Gln 
65                  70                  75                  80  


Asn Tyr Leu Pro Val Val Arg Tyr Leu Asp Lys Arg Asn Lys Glu Gly 
                85                  90                  95      


Phe Lys Asn Gln Val Glu Leu Leu Phe Lys Ser Leu Asp Ser Leu Arg 
            100                 105                 110         


Asn Phe Tyr Thr His Tyr Tyr His Ala Pro Leu Ser Leu Pro Gln Ala 
        115                 120                 125             


Leu Phe Asp Leu Leu Asp Ser Thr Phe Ala Lys Val Ala Ser Asp Val 
    130                 135                 140                 


Lys Ala Asn Lys Val Lys Asp Asp Lys Ser Arg His Leu Leu Lys Ser 
145                 150                 155                 160 


Ala Leu Ser Glu Glu Leu Asn Ala Arg Tyr Lys Leu Gln Leu Glu Arg 
                165                 170                 175     


Leu Lys Glu Leu Lys Ala Ser Gly Lys Lys Val Asn Leu His Asp His 
            180                 185                 190         


Asp Ala Ile Arg Asn Gly Val Leu Asn Ser Ser Phe Asn His Leu Ile 
        195                 200                 205             


Tyr Lys Asn Glu Ala Gly Asp Thr Ile Val Thr Arg Arg Tyr Ala Ala 
    210                 215                 220                 


Arg Tyr Ser Glu Ile Glu Ser Ala Glu Asn Gly Ile Thr Ile Ser Gln 
225                 230                 235                 240 


Ser Gly Leu Leu Phe Leu Ala Gly Leu Phe Leu Lys Arg Lys Glu Val 
                245                 250                 255     


Glu Asp Leu Lys Ser Arg Val Lys Gly Phe Lys Ala Lys Ile Ile Lys 
            260                 265                 270         


Glu Gly Glu Glu Asn Ile Ser Gly Leu Lys Tyr Met Ala Thr His Trp 
        275                 280                 285             


Ile Phe Ser Tyr Leu Ser Phe Lys Gln Pro Lys Gln Thr Leu Thr Asn 
    290                 295                 300                 


Asp Phe Asp Arg Glu Thr Leu Leu Leu Gln Ile Ile Asp Glu Leu Ser 
305                 310                 315                 320 


Lys Val Pro Asp Asp Val Tyr Gln Ala Phe Ser Glu Glu Thr Arg Asn 
                325                 330                 335     


Leu Phe Val Glu Asp Ile Asn Gln Tyr Leu Lys Glu Gly Asn Asp Asp 
            340                 345                 350         


Tyr Thr Leu Glu Glu Ala Gln Val Ile His Pro Val Ile Arg Lys Arg 
        355                 360                 365             


Tyr Glu Asn Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu Asp Glu Phe 
    370                 375                 380                 


Ala Gly Phe Thr Ser Leu Lys Phe Gln Val His Leu Gly Asn Tyr Ile 
385                 390                 395                 400 


His Asp Lys Arg Thr Lys His Ile Ser Gly Thr Glu Leu Gln Thr Glu 
                405                 410                 415     


Arg Arg Ile Lys Glu Arg Val Lys Val Phe Gly Lys Leu Ser Asp Ala 
            420                 425                 430         


Gln Arg Leu Lys Asn Asp Phe Phe Ala Asp Lys Ser Arg Arg Asp Gln 
        435                 440                 445             


Glu Leu Gly Trp Glu Ile Leu Pro Asn Pro Ser Tyr Val Phe Ile Glu 
    450                 455                 460                 


Asn Asn Ile Pro Ile Tyr Phe Lys Val Asp Asn Glu Val Ala Glu Ala 
465                 470                 475                 480 


Val Lys Ser Ala Lys Ala Ser Arg Lys Ser Leu Ser Pro Asp Glu Arg 
                485                 490                 495     


Lys Val Arg Ser Gly Asp Lys Ala Gln Lys His Ile Ile Leu Asn Ser 
            500                 505                 510         


Ile Ser Glu Arg Gly Leu Leu Arg Lys Asp Glu Pro Thr Ala Leu Leu 
        515                 520                 525             


Ser Leu Asn Glu Ile Pro Ala Leu Leu Tyr Glu Ile Leu Val Lys Gly 
    530                 535                 540                 


Thr Ser Pro Val Glu Ile Glu Glu Ile Leu Lys Ser Lys Ala Val Glu 
545                 550                 555                 560 


Arg Val Gln Val Ile Lys Asn Tyr Thr Pro Glu Gln Pro Leu Pro Gly 
                565                 570                 575     


Ser Gln Ile Ser Lys Arg Leu Arg Ser Asn Thr Ala Val Thr Gly Lys 
            580                 585                 590         


Gln Tyr Asn Val Asp Lys Leu Gln Gln Leu Leu Lys Lys Glu Ile Phe 
        595                 600                 605             


Leu Ala Asp Glu Lys Leu Ala Leu Ile Tyr Lys Asn Arg Val Glu Leu 
    610                 615                 620                 


His Lys Lys Ile Gly Gly Lys Val Leu Arg Asn Tyr Val Phe Gly Phe 
625                 630                 635                 640 


Ser Glu Leu Gly Arg Glu Ala Thr Trp Ile Ala Glu Asp Ile Lys Arg 
                645                 650                 655     


Phe Met Pro Leu Pro Ala Arg Arg Glu Trp Lys Gly Tyr Gln His Ser 
            660                 665                 670         


Gln Leu Gln Gln Ser Leu Ser Tyr Tyr Glu Ser Arg Pro Asn Glu Ala 
        675                 680                 685             


Phe Asn Ile Leu Lys Asp Asn Trp Asn Phe Asp Asp Gly Ala Met Leu 
    690                 695                 700                 


Trp Asn Ser Trp Ile Lys Asp Ser Phe Asn Glu Lys Phe Phe Asp Arg 
705                 710                 715                 720 


Phe Tyr Glu Arg Tyr Leu His Gly Lys Arg Lys Tyr Leu Glu Asn Phe 
                725                 730                 735     


Leu Glu Asn Ile Gln Asn Phe Ser Pro Gly Ser Asn Lys Ile Leu Glu 
            740                 745                 750         


Lys Phe Leu Cys Gln Gln Met Pro Lys Asn Phe Phe Asp Lys Arg Leu 
        755                 760                 765             


Tyr Val Leu Glu Pro Leu Glu Gln Glu Lys Asp Lys Ile Leu Ser Tyr 
    770                 775                 780                 


Pro Leu Val Phe Pro Arg Gly Leu Phe Asp Pro Ala Pro Thr Phe Ile 
785                 790                 795                 800 


Lys Gly Val Gln Val Met Glu Glu Pro Glu Arg Phe Ala Ala Trp Tyr 
                805                 810                 815     


Arg Tyr Gly Tyr Ser Pro Asp His Pro Phe Gln Arg Phe Tyr Glu Met 
            820                 825                 830         


Glu Arg Asp Tyr Thr Asp Leu Ile Asn Asp Asp Thr Glu Thr Arg Pro 
        835                 840                 845             


Asp Thr Asp Lys Asn Lys Ser Asp Phe Ser Ser Glu Gln Gln Tyr Ala 
    850                 855                 860                 


Leu Ile Lys Lys Lys Gln Asp Leu Lys Ile Lys Asn Ile Lys Ile Gln 
865                 870                 875                 880 


Asp Leu Phe Leu Lys Leu Ile Ala Glu Thr Leu Phe Ser Asp Ile Phe 
                885                 890                 895     


Asp Tyr Asp Ser Glu Ile Arg Leu Ser Asp Leu Tyr Leu Thr Gln Ala 
            900                 905                 910         


Glu Arg Ile Glu Lys Glu Gln Asn Ala Ala Gln Gln Ser Ile Arg Pro 
        915                 920                 925             


Ala Gly Asp Asp Ser Asp Asn Ile Ile Lys Asp Asn Phe Ile Trp Ser 
    930                 935                 940                 


Lys Thr Ile Pro Tyr Ile Lys Asp Gln 
945                 950             


<210>  2411
<211>  1322
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2411

Met Ala Asn Asn Gln Phe His Leu Val Ser Val Asp Tyr Ser Lys Pro 
1               5                   10                  15      


Tyr Asp Glu Gln Pro Glu Cys Lys Arg His Ile Val Gly Ala Tyr Ala 
            20                  25                  30          


Asn Leu Ala Arg His Asn Met Thr Val Thr Ile Asn Val Ile Met Gln 
        35                  40                  45              


Ala Ile Gly Met Pro Leu Phe Asn Glu Asn Asp Ile Asp Asp Ala Phe 
    50                  55                  60                  


Asn Lys Gly His Arg Lys Lys Leu Asp Lys Leu Asp Ile Ile Gln Lys 
65                  70                  75                  80  


Val Asn Leu Gln Asn Arg Leu Tyr Arg His Phe Pro Phe Phe Lys Arg 
                85                  90                  95      


Met Arg Leu Glu Asp Lys Asn Lys Lys Ser Val Gln Leu Asp Thr Leu 
            100                 105                 110         


Met Glu Val Met Ser Glu Phe Thr Ala Cys Met Ala Ile Ile Arg Asn 
        115                 120                 125             


Phe Tyr Thr His Tyr His Pro Tyr Asn Ser Pro Asn Glu Leu Ala Asn 
    130                 135                 140                 


Gln Leu Glu Leu Lys Glu Arg Met Gly Lys Arg Leu Gln Tyr Leu Phe 
145                 150                 155                 160 


Glu Asn Thr Ser Gln Met Phe Lys Ser Asn Glu Lys Leu Asp His Glu 
                165                 170                 175     


Ser Asn Glu Val Phe Ala Ala Leu Arg Ile Pro Lys Asp Phe Val Glu 
            180                 185                 190         


Glu Phe Val Pro Gly Asp Glu Asp Tyr Gln Ala Leu Tyr Asp Leu Leu 
        195                 200                 205             


Asn Asp Pro Lys Val Ser His Ser Gln Lys Arg Gly Ile Ser Leu Asp 
    210                 215                 220                 


Met Lys Thr Gln Lys Ile Thr Lys Lys Thr Val Arg Tyr Ile Arg Asn 
225                 230                 235                 240 


Pro Glu Phe Gln Ala Tyr Met Met Asp Lys Asn Asn Gly Met Ser Asp 
                245                 250                 255     


Ile Ala Ile Ile Tyr Phe Leu Cys Leu Phe Leu Glu Lys Lys Val Ser 
            260                 265                 270         


Phe Glu Leu Met Lys Glu Val Gly Leu Thr Gln Gln Ile Lys Phe Glu 
        275                 280                 285             


Gly Glu Asn Ala Asp Gln Gln Leu Leu Phe Val Lys Glu Ile Met Cys 
    290                 295                 300                 


Met Asn Arg Ile Arg Met Thr Lys Thr Lys Leu Asp Ser Glu Met Thr 
305                 310                 315                 320 


Asp Thr Ala Leu Ala Leu Asp Met Ile Asn Glu Leu Arg Lys Cys Pro 
                325                 330                 335     


Lys Pro Leu Tyr Glu Val Leu Cys Lys Glu Ala Arg Asp Glu Phe Lys 
            340                 345                 350         


Asp Asp Ser Thr Ile Gln Trp Glu Lys Glu His Gly Asn Glu Ala Val 
        355                 360                 365             


Glu Thr Glu Asp Asn Gly Asp Asp Ser Glu Glu Glu Arg Thr Val Glu 
    370                 375                 380                 


Lys Glu Thr Pro Arg Ser Thr Phe Val Arg Trp Glu Asp Arg Phe Pro 
385                 390                 395                 400 


Lys Met Ala Leu Ser Tyr Ile Asp Tyr Gln Gly Leu Phe Lys Asp Ile 
                405                 410                 415     


Arg Phe Gln Leu Asn Leu Gly Lys Tyr Arg Phe Ser Phe Tyr Ser His 
            420                 425                 430         


Asp Lys Asn Gln Ser Val Asp Gly Arg Glu Arg Leu Arg Val Leu Gln 
        435                 440                 445             


Lys Glu Ile His Gly Phe Gly Arg Ile Lys Glu Val Asn Ala Lys Lys 
    450                 455                 460                 


Ser Ile Lys Trp Ala Asp Leu Tyr Glu Asn Lys Tyr Val Glu Asp Gly 
465                 470                 475                 480 


Leu Thr Lys Lys Lys Pro Asp Glu Ala Gly Gln Thr Pro Tyr Val Thr 
                485                 490                 495     


Glu Gln Tyr Pro Gln Tyr Ala Ile Asp Glu Lys Ser His Ser Ile Gly 
            500                 505                 510         


Leu Arg Trp Glu Gly Trp Lys Ala Thr Gly Asp Ser Lys Lys His Tyr 
        515                 520                 525             


Gly Asp Leu Asp Ser Gln Gln Met Phe Ile Pro Tyr Leu Pro Thr Lys 
    530                 535                 540                 


Pro Leu Pro Glu Glu Lys Gln Thr Tyr Gln Gly Glu Pro Leu Leu Pro 
545                 550                 555                 560 


Pro Gln Ala Leu Leu Ser Leu Tyr Glu Leu Pro Gly Leu Leu Phe Tyr 
                565                 570                 575     


Gln Tyr Leu Ser Val Lys Gln Gly Lys Asn Lys Tyr Glu Thr Glu Asn 
            580                 585                 590         


Ile Ile Lys Asp Tyr Cys Thr His Leu Gln Gln Phe Phe Asn Asp Val 
        595                 600                 605             


Ala Lys Gly Val Leu Asn Pro Leu Ile Gly Glu Pro Ile Lys Asp Val 
    610                 615                 620                 


Glu Lys Glu Lys Gln Leu Trp Glu Arg Arg Lys Ala Glu Leu Asn Lys 
625                 630                 635                 640 


Lys Leu Glu Ala Tyr His Leu Arg Asp Cys Asp Ile Pro Thr Lys Leu 
                645                 650                 655     


Arg Asp Phe Leu Cys Asn Arg Glu Ile Asp Tyr Ala Gln Lys Leu Glu 
            660                 665                 670         


Asn Ser Ala Leu Asn Arg Leu Ala Glu Arg Lys Asn Gln Ile Glu Lys 
        675                 680                 685             


Ala Leu Ser Ser Phe Ser Glu Lys Lys Lys Arg Ile Gly Ser Lys Asp 
    690                 695                 700                 


Asn Lys Phe Asp Arg Lys Arg Ala Ile Ile Lys Thr Gly Gln Leu Ala 
705                 710                 715                 720 


Gln Met Leu Ile Arg Asp Ile Ala Ser Trp Leu Pro Asn Asn Ser Gln 
                725                 730                 735     


Ser Leu Gln Lys Leu Thr Gly Gln Lys Tyr Thr Val Leu Gln Ser Ala 
            740                 745                 750         


Leu Thr Met Leu Gly Gln Asn Gln Thr Asn Thr Glu Val Ser Pro Ile 
        755                 760                 765             


Trp Ile Lys Asp Ile Glu Arg Tyr Phe Ala Glu Ala Leu Val Ile Ala 
    770                 775                 780                 


Lys Pro Asn Glu Glu Trp Leu Pro Thr Cys His His Pro Phe Leu Gln 
785                 790                 795                 800 


Glu Val Met Asn Lys Cys Glu Glu Asp Cys Ser Ile Glu Glu Leu Tyr 
                805                 810                 815     


Glu Lys Tyr Leu Lys Lys Glu Leu Glu His Ile Asp Asn Val Lys Lys 
            820                 825                 830         


Lys Ile Asp Asp Gly Lys Asp Phe Asp Val Tyr Leu Leu Ile Pro Phe 
        835                 840                 845             


Leu His Cys Glu Arg Gln Arg Trp Glu Glu Gln Asp Ala Ser Thr Met 
    850                 855                 860                 


Arg Asn Leu Ala Lys Arg Tyr Ser Glu Arg Pro Val Gln Leu Pro Asn 
865                 870                 875                 880 


Asn Met Phe Val Ala Tyr Val Val Arg Leu Met Met Glu Ile Asp Asn 
                885                 890                 895     


Pro Glu Leu His Lys Ala Ile Glu Lys Val Lys Lys Tyr Glu Lys Gly 
            900                 905                 910         


Glu Gln Leu Thr Asn Asn Val Ala Tyr Leu Ile Arg Leu Tyr Phe Glu 
        915                 920                 925             


Leu Val Glu His Asp His Ser Gln Pro Phe Tyr Asn Thr Ser Asp Ile 
    930                 935                 940                 


Asp Gly Glu Leu Ser Pro Tyr Arg His Val Tyr Arg Leu Phe Lys Lys 
945                 950                 955                 960 


Leu Tyr Gly Glu Lys Ile Pro His Thr Asn Arg Lys Thr Thr Pro Ser 
                965                 970                 975     


Tyr Ser Ile Glu Glu Leu Arg Asn Leu Arg Lys Gln Ala Ile Val Asp 
            980                 985                 990         


Ile Glu Ala Tyr Val Asn Gln Glu  Ile Gln Thr Trp Glu  Thr Lys Lys 
        995                 1000                 1005             


Lys His  Arg Phe Val Gln Asn  Leu Lys Trp Lys Leu  Lys Lys Glu 
    1010                 1015                 1020             


Asn Asp  Arg Arg Tyr Lys Asn  His Lys Arg Gln Leu  Asn Ile Thr 
    1025                 1030                 1035             


Glu Glu  Leu Asn Lys Ala Val  Gln Gln Glu Ile Asn  Glu Ile Arg 
    1040                 1045                 1050             


Thr Thr  Thr Thr Ala Lys Leu  Leu Arg Gln Leu Lys  Lys Val Tyr 
    1055                 1060                 1065             


Asp Asn  Glu Arg Val Ile Arg  Arg Phe Lys Thr Gln  Asp Met Leu 
    1070                 1075                 1080             


Met Leu  Ile Met Ala Arg Glu  Ile Leu Lys Ala Lys  Ser Gln Asp 
    1085                 1090                 1095             


Lys Asp  Phe Thr Lys Asp Phe  Cys Leu Lys Tyr Val  Met Thr Asp 
    1100                 1105                 1110             


Ser Leu  Leu Asp Lys Pro Ile  Asp Phe Asp Trp Asn  Val Asn Ile 
    1115                 1120                 1125             


Glu Lys  Lys Arg Lys Asn Glu  Ser Gly Arg Ile Glu  Lys Glu Ile 
    1130                 1135                 1140             


Val Leu  Lys Thr Ile Arg Gln  Glu Gly Met Lys Met  Lys Asn Tyr 
    1145                 1150                 1155             


Gly Gln  Phe Tyr Lys Phe Ala  Ser Asp His Gln Arg  Leu Glu Ser 
    1160                 1165                 1170             


Leu Leu  Ser Arg Leu Pro Asp  Asn Ile Phe Leu Arg  Ala Glu Ile 
    1175                 1180                 1185             


Glu Asn  Glu Leu Ser Tyr Tyr  Asp Thr Asn Arg Ser  Glu Val Phe 
    1190                 1195                 1200             


Arg Gln  Val Tyr Ile Ile Glu  Ser Glu Ala Tyr Lys  Leu Lys Pro 
    1205                 1210                 1215             


Glu Leu  Glu Asn Asp Asn Asn  Ala Gly Glu Glu Trp  Phe Cys Tyr 
    1220                 1225                 1230             


Val Asp  Lys Lys Gly Lys Lys  His Pro Lys Arg Asn  Asn Phe Leu 
    1235                 1240                 1245             


Ser Leu  Leu Glu Ile Leu Ala  Ala Gly Lys Asp Gly  Ile Leu Asp 
    1250                 1255                 1260             


Glu Asp  Glu Lys Arg Asn Leu  Gln Ser Thr Arg Asn  Ala Phe Gly 
    1265                 1270                 1275             


His Asn  Thr Tyr Asp Val Asp  Leu Pro Thr Val Phe  Glu Gly Lys 
    1280                 1285                 1290             


Glu Glu  Lys Met Lys Ile Pro  Glu Val Ala Asn Gly  Ile Lys Asp 
    1295                 1300                 1305             


Lys Ile  Glu Glu Gln Thr Val  Glu Leu Lys Lys Asn  Leu Asn 
    1310                 1315                 1320         


<210>  2412
<211>  1094
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2412

Met Glu Ala Asn Glu Gln Asn Gln Glu Asn Arg Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Asn Asn His Ile Ala Ala Asp Phe Gly Gln Ala Val 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ser Gly Phe Leu Cys Asn Lys Glu 
    50                  55                  60                  


Ile Lys Lys Leu Asn Trp Asn His Ile Tyr Ala Lys Thr Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ile Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Val Asn Ser Asp Lys Glu Gly Lys Asp Phe Ala Ala Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Ser Glu Leu Gln Asp Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Glu Asn Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Ala Glu Leu Thr Asp Met Leu Thr Ile Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Thr Asp Ala Asp Tyr 
                165                 170                 175     


Glu Leu Val Glu Thr Lys Gln Val Val Thr Thr Gly Asn Ile Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Met Phe Leu Glu Arg Glu His 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asn Leu Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Gly 
            260                 265                 270         


Val Ile Thr Asp Glu Glu Lys Met Gln Phe Arg Pro Glu Leu Asp Glu 
        275                 280                 285             


Leu Asp Ile Glu Lys Leu Ile Ala Asn Ser Thr Asn Asp Asp Glu Arg 
    290                 295                 300                 


Glu Arg Ile Leu Asp Glu Ile Gly Tyr Glu Glu Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg Tyr Asn Asn Arg Phe Pro Tyr Phe Ala Met Arg 
                325                 330                 335     


Phe Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Arg Tyr Thr Lys Gln Leu Ala Gly Glu 
        355                 360                 365             


Gln Thr Glu Arg Val Val Gln Glu Asn Val Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asp Pro Glu Leu Ile Gln Gln Lys Ile Asp Asn Gln 
385                 390                 395                 400 


Gln Arg Thr Asp Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Ile Ala Ile Leu Ile 
            420                 425                 430         


Pro Lys Ser Lys Pro Glu Ser Lys Val Gly Asn Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Asp Tyr Leu Gln Lys Gly Lys Ala Glu Glu Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Ile Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Leu Lys Leu Pro Ala Asn Trp Asn Glu Phe Ala Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asp Ala Ala Met Glu Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Asp Val Leu Ile Thr Tyr Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Asp Val Glu Asp Asn Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Leu Glu Lys His Lys Leu 
            580                 585                 590         


Asp Lys Ser Val Lys Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Met Val Ser Lys Glu Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Ala Asp Thr Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Val Leu Glu Gly Asp Gly His Pro Phe Leu Thr Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Glu Leu Tyr Met Asn 
        675                 680                 685             


Ala Lys Val Gln Tyr Leu Ile Gln Phe Tyr Lys Pro Ser Lys Asp Lys 
    690                 695                 700                 


Val Asp Lys Arg Gly Arg Pro Thr Thr Glu Val Lys Leu Pro Pro Leu 
705                 710                 715                 720 


Asp Lys Arg Ser Asn Ile Pro Phe Thr Ile Arg Gln Trp Asp Glu Lys 
                725                 730                 735     


Glu Lys Tyr Asn Leu Asn Ala Trp Leu Arg Asn Val Thr Val Gly Lys 
            740                 745                 750         


Asn Thr Lys Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe 
        755                 760                 765             


Asp Glu Thr Leu Cys Asp Leu Leu Ser Gln Gln Leu Asp Ala Arg Thr 
    770                 775                 780                 


Val Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Leu Trp 
785                 790                 795                 800 


Trp Lys Thr Arg Asp Asp Ala Thr Gln Asp Phe Tyr Gln Ser Glu Arg 
                805                 810                 815     


Glu Tyr Asp Ile Tyr Glu Glu Lys Val Glu Phe Lys Ile Asp Ser Ser 
            820                 825                 830         


Gly His Phe Ala Asp Tyr Tyr Lys Lys Ala Leu Ser Lys Ala Tyr Asn 
        835                 840                 845             


Arg Leu Lys Ala Glu Arg Glu Ile Ala Arg Arg Thr Asn Lys Arg Leu 
    850                 855                 860                 


Pro Pro Ile Glu His Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile 
865                 870                 875                 880 


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
                885                 890                 895     


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asp Ser Gly Asn Leu Lys 
            900                 905                 910         


Leu Ser Thr Ile Lys Thr Ser Leu Asn Asn Thr Thr Gln Ile Lys Gln 
        915                 920                 925             


Lys Ile Leu Asn Lys Thr Ile Val Ala Glu Arg Lys Gln Lys Asn Tyr 
    930                 935                 940                 


Thr Glu Leu Arg Lys Tyr Val His Asp Arg Arg Leu Pro Asn Leu Phe 
945                 950                 955                 960 


Glu Tyr Val Glu Ala Asp Glu Ile Leu Leu Glu Trp Leu Leu Asp Glu 
                965                 970                 975     


Leu Met Ala Tyr Asn Ala Ala Lys Gln Gln Val Phe Asp Thr Ile Phe 
            980                 985                 990         


Met Leu Glu Lys Arg Ile Ile Glu  Thr Asp Pro Gln Glu  Leu Lys Ser 
        995                 1000                 1005             


Leu Phe  Thr Asn Glu Lys Gly  Gln Val Gln Thr Gly  Asn Ile Gln 
    1010                 1015                 1020             


His Lys  Pro Tyr Val Gln Trp  Leu Lys Asn Lys Gly  Leu Ile Asn 
    1025                 1030                 1035             


His Asn  Glu Lys Leu Phe Ile  Asn Met Val Arg Asn  Cys Phe Ser 
    1040                 1045                 1050             


His Asn  Gln Phe Pro Gln Arg  Glu Thr Met Glu Leu  Leu Ile Ser 
    1055                 1060                 1065             


Glu Trp  Gly Ala Gly Lys Ile  Ala Thr Gln Ile Leu  Thr Val Tyr 
    1070                 1075                 1080             


Asn Gln  Leu Ile Thr Asn Ile  Ile Asn Lys Ile 
    1085                 1090                 


<210>  2413
<211>  1125
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2413

Met Glu Asp Asp Lys Lys Thr Lys Glu Ser Thr Asn Met Leu Asp Asn 
1               5                   10                  15      


Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val Tyr 
            20                  25                  30          


Ile Thr Val Asn His Ile Asn Lys Val Leu Glu Leu Lys Asn Lys Lys 
        35                  40                  45              


Asp Gln Asp Ile Leu Ile Asp Asn Asp Gln Asp Ile Leu Ala Ile Lys 
    50                  55                  60                  


Thr His Trp Glu Lys Val Asn Gly Asp Leu Asn Lys Thr Glu Arg Leu 
65                  70                  75                  80  


Arg Glu Leu Met Thr Lys His Phe Pro Phe Leu Glu Thr Ala Ile Tyr 
                85                  90                  95      


Thr Lys Asn Lys Glu Asp Lys Glu Glu Val Lys Gln Glu Lys Gln Ala 
            100                 105                 110         


Lys Ala Gln Ser Phe Asp Ser Leu Lys His Cys Leu Phe Leu Phe Leu 
        115                 120                 125             


Glu Lys Leu Gln Glu Ala Arg Asn Tyr Tyr Ser His Tyr Lys Tyr Ser 
    130                 135                 140                 


Glu Ser Thr Lys Glu Pro Met Leu Glu Lys Glu Leu Leu Lys Lys Met 
145                 150                 155                 160 


Tyr Asn Ile Phe Asp Asp Asn Ile Gln Leu Val Ile Lys Asp Tyr Gln 
                165                 170                 175     


His Asn Lys Asp Ile Asn Pro Asp Glu Asp Phe Lys His Leu Asp Arg 
            180                 185                 190         


Thr Glu Glu Asp Phe Asn Tyr Tyr Phe Thr Arg Asn Lys Lys Gly Asn 
        195                 200                 205             


Ile Thr Ala Ser Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys 
    210                 215                 220                 


Lys Asp Ala Ile Trp Met Gln Gln Lys Leu Arg Gly Phe Lys Asp Asn 
225                 230                 235                 240 


Arg Glu Ser Lys Lys Lys Met Thr His Glu Val Phe Cys Arg Ser Arg 
                245                 250                 255     


Met Leu Leu Pro Lys Leu Arg Leu Glu Ser Thr Gln Thr Gln Asp Trp 
            260                 265                 270         


Ile Leu Leu Asp Met Leu Asn Glu Leu Ile Arg Cys Pro Lys Ser Leu 
        275                 280                 285             


Tyr Glu Arg Leu Gln Gly Glu Asp Arg Glu Lys Phe Lys Val Pro Phe 
    290                 295                 300                 


Asp Pro Thr Asp Glu Asn Tyr Asp Ala Glu Gln Glu Pro Phe Lys Asn 
305                 310                 315                 320 


Thr Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr 
                325                 330                 335     


Phe Asp Tyr Asn Glu Val Phe Ala Asn Leu Arg Phe Gln Ile Asp Leu 
            340                 345                 350         


Gly Thr Tyr His Phe Ser Ile Tyr Lys Lys Leu Ile Gly Gly Gln Lys 
        355                 360                 365             


Glu Asp Arg His Leu Thr His Lys Leu Tyr Gly Phe Glu Arg Ile Gln 
    370                 375                 380                 


Glu Phe Ala Lys Gln Asn Arg Pro Asp Glu Trp Lys Ala Ile Val Lys 
385                 390                 395                 400 


Asp Leu Asp Thr Tyr Glu Thr Ser Glu Glu Pro Tyr Ile Ser Glu Thr 
                405                 410                 415     


Thr Pro His Tyr His Leu Glu Asn Gln Lys Ile Gly Ile Arg Phe Arg 
            420                 425                 430         


Asn Gly Asn Asn Asp Ile Trp Pro Ser Leu Glu Thr Asn Gly Glu Asn 
        435                 440                 445             


Asn Glu Lys Ser Lys Tyr Lys Leu Asp Lys Gln Tyr Gln Ala Glu Ala 
    450                 455                 460                 


Phe Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu 
465                 470                 475                 480 


Leu Lys Lys Glu Lys Pro Asn Asn Asp Glu Ile Asn Ala Ser Ile Val 
                485                 490                 495     


Glu Gly Phe Ile Lys Arg Glu Ile Arg Tyr Ile Tyr Lys Leu Tyr Asp 
            500                 505                 510         


Ala Phe Ala Asn Gly Glu Ile Asn Asn Ile Asp Asp Leu Lys Lys Tyr 
        515                 520                 525             


Cys Glu Asp Lys Gly Ile Pro Lys Arg Asn Leu Pro Lys Gln Met Ile 
    530                 535                 540                 


Ala Ile Leu Glu Ser Lys Pro Lys Asp Met Val Glu Glu Ala Glu Arg 
545                 550                 555                 560 


Lys Gln Arg Lys Met Val Lys Asp Thr Lys Lys Leu Leu Ala Thr Leu 
                565                 570                 575     


Glu Lys Gln Thr Gln Gly Glu Ile Glu Asp Gly Gly Arg Asn Ile Arg 
            580                 585                 590         


Leu Leu Lys Ser Gly Glu Ile Ala Arg Trp Leu Val Asn Asp Met Met 
        595                 600                 605             


Arg Phe Gln Pro Val Gln Lys Asp Asn Glu Gly Asn Pro Leu Asn Asn 
    610                 615                 620                 


Ser Lys Ala Asn Ser Thr Glu Tyr Gln Met Leu Gln Arg Ser Leu Ala 
625                 630                 635                 640 


Leu Tyr Asn Lys Glu Glu Lys Pro Thr Arg Tyr Phe Arg Gln Val Asn 
                645                 650                 655     


Leu Ile Glu Ser Ser Asn Pro His Pro Phe Leu Asn Asn Thr Glu Trp 
            660                 665                 670         


Lys Glu Cys Asn Asn Ile Leu Ser Phe Tyr Arg Ser Tyr Leu Thr Lys 
        675                 680                 685             


Lys Ile Glu Phe Leu Asn Glu Leu Lys Pro Glu Asp Trp Glu Lys Asn 
    690                 695                 700                 


Gln Tyr Phe Leu Lys Leu Lys Glu Pro Lys Thr Asn Arg Glu Thr Leu 
705                 710                 715                 720 


Val Gln Gly Trp Lys Asn Gly Phe Asn Leu Pro Arg Gly Ile Phe Thr 
                725                 730                 735     


Glu Pro Ile Arg Glu Trp Phe Lys Arg His Gln Asn Asp Ser Glu Glu 
            740                 745                 750         


Tyr Lys Lys Val Glu Ala Leu Lys Arg Val Gly Leu Val Thr Lys Val 
        755                 760                 765             


Ile Pro Leu Phe Phe Lys Glu Glu Tyr Phe Lys Glu Asp Ala Gln Lys 
    770                 775                 780                 


Glu Ile Asn Asn Cys Val Gln Pro Phe Tyr Gly Phe Pro Tyr Asn Val 
785                 790                 795                 800 


Gly Asn Ile His Lys Pro Lys Glu Glu Asp Phe Leu His Arg Glu Glu 
                805                 810                 815     


Arg Ile Glu Leu Trp Asp Lys Lys Lys Asp Lys Phe Lys Gly Tyr Lys 
            820                 825                 830         


Ala Lys Lys Lys Phe Lys Glu Met Thr Asp Lys Glu Lys Glu Glu His 
        835                 840                 845             


Arg Ser Tyr Leu Glu Phe Lys Ser Trp Asn Gln Phe Glu Arg Glu Leu 
    850                 855                 860                 


Arg Leu Val Arg Asn Gln Asp Ile Val Thr Trp Leu Leu Cys Met Glu 
865                 870                 875                 880 


Leu Ile Asp Lys Leu Lys Val Glu Gly Leu Asn Val Glu Glu Leu Gln 
                885                 890                 895     


Lys Leu Arg Leu Lys Asp Ile Asp Thr Asp Thr Ala Lys Gln Glu Lys 
            900                 905                 910         


Asn Asn Ile Leu Asn Arg Val Met Pro Met Gln Leu Pro Val Thr Val 
        915                 920                 925             


Tyr Glu Ile Asp Asp Ser His Asn Ile Val Lys Asp Arg Pro Leu His 
    930                 935                 940                 


Thr Val Tyr Ile Glu Glu Thr Lys Thr Lys Leu Leu Lys Gln Gly Asn 
945                 950                 955                 960 


Phe Lys Ala Leu Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe 
                965                 970                 975     


Val Asp Thr Ser Ser Glu Ala Glu Leu Lys Ser Lys Pro Ile Ser Lys 
            980                 985                 990         


Leu Arg Val Glu Tyr Glu Leu Gly  Glu Tyr Gln Asn Ala  Arg Ile Glu 
        995                 1000                 1005             


Ile Ile  Glu Asp Met Leu Ala  Leu Glu Gly Ala Leu  Ile Glu Lys 
    1010                 1015                 1020             


Asp Lys  Asn Leu Pro Thr Asp  Asn Phe Ser Asp Met  Leu Asn Gly 
    1025                 1030                 1035             


Trp Leu  Glu Gly Lys Asp Glu  Ser Asp Lys Ala Arg  Phe Gln Asn 
    1040                 1045                 1050             


Asp Val  Lys Leu Leu Val Ala  Val Arg Asn Ala Phe  Ser His Asn 
    1055                 1060                 1065             


Gln Tyr  Pro Met Arg Asn Arg  Ile Ala Phe Ala Asn  Ile Asn Pro 
    1070                 1075                 1080             


Phe Ser  Leu Ser Ser Ala Asp  Ile Ser Glu Glu Lys  Gly Leu Asn 
    1085                 1090                 1095             


Ile Ala  Asn Gln Leu Lys Asp  Lys Thr Lys Glu Thr  Ile Asp Lys 
    1100                 1105                 1110             


Ile Ile  Glu Ile Glu Lys Pro  Ile Glu Thr Lys Glu  
    1115                 1120                 1125 


<210>  2414
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2414

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2415
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2415

Met Glu Thr Lys Gln Gln Val Gly Lys Gly Ile Ser Tyr Asp His Arg 
1               5                   10                  15      


Arg Pro Asp Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asp Gly Val Ile Gln Glu Phe Ala Met Arg Leu Asn Arg 
        35                  40                  45              


Glu Tyr Asp Pro Glu Asn Lys Asn Gln Ser Leu Phe Ser Tyr Phe Asn 
    50                  55                  60                  


Ile Asn Ala Ser Phe Thr Asp Trp Glu Arg Gly Val Asn Ile Leu Lys 
65                  70                  75                  80  


Glu Tyr Trp Pro Met Met Glu Phe Ile Asp Arg Pro Ala Thr Asp Lys 
                85                  90                  95      


Gln Phe Glu Ala Glu Lys Pro Glu Asn Arg Glu Ala Ala Lys Arg Lys 
            100                 105                 110         


Tyr Phe Leu Ala Thr Leu Gly Ala Leu Leu Thr Ser Ile Lys Asp Leu 
        115                 120                 125             


Arg His Tyr Tyr Thr His Tyr Tyr His Pro Pro Val His Leu Asn Asp 
    130                 135                 140                 


Asp Leu Phe Leu Phe Leu Asp His Ala Leu Leu Tyr Thr Ala Phe Asp 
145                 150                 155                 160 


Val Lys Lys Thr Lys Met Lys Asp Asp Lys Thr Arg Gln Leu Leu Asn 
                165                 170                 175     


Gln Asn Leu Ser Leu Glu Leu Glu Lys Leu Lys Lys Leu Lys Val Glu 
            180                 185                 190         


Glu Leu Lys Lys Lys Lys Glu Lys Gly Ile Lys Val Asn Leu Gln Asp 
        195                 200                 205             


Glu Lys Gly Ile Leu Asn Ala Ile Tyr Asn Asp Ala Phe Ala His Ile 
    210                 215                 220                 


Ile Thr Lys Glu Lys Asp Ser Asp Lys Asp Lys Leu Glu Thr Arg Tyr 
225                 230                 235                 240 


Lys Ser Ile Leu Pro Gln Asp Glu Ala Ala Glu Thr Gly Ile Asn Ile 
                245                 250                 255     


Ser Ile Ser Gly Leu Ile Phe Leu Leu Ser Leu Phe Leu Ser Arg Lys 
            260                 265                 270         


Glu Ile Glu Gln Leu Lys Ser Asn Ile Glu Gly Tyr Lys Gly Lys Val 
        275                 280                 285             


Leu Asn Ile Glu Thr Glu Val Asp Arg Lys His Asn Ser Leu Lys Tyr 
    290                 295                 300                 


Met Ala Thr His Trp Val Phe Ser Ile Leu Ala Phe Lys Gly Leu Lys 
305                 310                 315                 320 


Gln Arg Leu Thr Asn Ser Phe Glu Lys Glu Ser Leu Leu Ile Gln Met 
                325                 330                 335     


Met Asp Glu Leu Asn Lys Val Pro Asp Glu Leu Tyr Gln Thr Leu Ser 
            340                 345                 350         


Glu Thr Ala Lys Lys Glu Phe Leu Glu Asp Ile Asn Glu Tyr Val Ser 
        355                 360                 365             


Glu Gly Asp Asp Asn Glu Lys Ala Thr Tyr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Ser Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gln Phe Pro Thr Leu Lys Phe Gln Ile Phe Val Gly 
                405                 410                 415     


Gln Tyr Leu His Asp Asn Arg Pro Lys Thr Leu Ala Ser Asn Gly Met 
            420                 425                 430         


Thr Ala Gln Arg Met Ile Lys Glu Lys Ile Asn Leu Phe Gly Asn Leu 
        435                 440                 445             


Ser Glu Val Thr Lys His Lys Ser Asp Phe Phe Glu Lys Glu Ser Ala 
    450                 455                 460                 


Ala Gln Gly Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Trp Ala Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Val Tyr Ile Asp Met Ile Gly Lys Glu Gly Lys Ala 
                485                 490                 495     


Lys Glu Ile Gln Val Gln Ile Asn Lys Tyr Arg Lys Gln Leu Asn Pro 
            500                 505                 510         


Ala Pro Gln Arg Asp Lys Arg Ile Ser Lys Lys Glu Ile Ile Glu Gln 
        515                 520                 525             


Leu Tyr Lys Glu Lys Val Val Tyr Gly Asp Pro Thr Leu Met Leu Ser 
    530                 535                 540                 


Ala Asn Glu Leu Met Ala Leu Leu Tyr Glu Leu Ile Val Asn Gly Lys 
545                 550                 555                 560 


Ser Gly Ala Glu Leu Glu Asn Lys Ile Val Glu Gln Ile Ile Ala Arg 
                565                 570                 575     


Tyr Glu Gln Ile Glu Ala Tyr Asp Pro Thr Thr Gln Gln Leu Pro Thr 
            580                 585                 590         


Asn Gln Met Pro His Lys Leu Gln Lys Ser Arg Lys Asp Ser Lys Val 
        595                 600                 605             


Thr Asp Thr Asp Lys Leu Leu Lys Thr Ile Asp Lys Glu Ile Asp Glu 
    610                 615                 620                 


Gly Asn Lys Lys Leu Glu Leu Ile Ala Cys His Arg Lys Glu Trp Glu 
625                 630                 635                 640 


Glu Ala Glu Gln Arg Lys Lys Ser Gly Lys Arg Asn Asn Pro Gly Thr 
                645                 650                 655     


Lys Ser Arg Lys His Leu Phe Tyr Ala Ser Glu Met Gly Glu Glu Ala 
            660                 665                 670         


Thr Trp Ile Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Pro Ala Arg 
        675                 680                 685             


Ala Glu Trp Lys Gly Thr His His Ser Glu Leu Gln Arg Leu Leu Ala 
    690                 695                 700                 


Phe Tyr Ser Thr Gln Arg Leu Glu Ala Trp Gln Leu Val Glu Ser Val 
705                 710                 715                 720 


Trp Thr Ala Asn Thr His Ser Phe Trp Glu Glu Asn Phe Lys Glu Ala 
                725                 730                 735     


Phe Tyr Lys Pro Glu Phe Glu Asn Phe Tyr Gly Ala Tyr Ile Glu Ile 
            740                 745                 750         


Arg Thr Lys Ile Leu Thr Thr Cys Arg Ser Ile Leu Glu Asn Asn Pro 
        755                 760                 765             


Glu Ala Thr Met Asn Asn Asp Thr Glu Lys Glu Trp Asp Lys Val Phe 
    770                 775                 780                 


Thr Leu Phe Asp Lys Arg Leu Tyr Arg Thr Ser Thr Thr Asp Glu Gln 
785                 790                 795                 800 


Lys Lys Gln Leu Leu Thr Lys Pro Phe Ala Phe Pro Arg Gly Leu Phe 
                805                 810                 815     


Asp Asp Lys Pro Thr Phe Leu Pro Gly Ser Lys Pro Asn Glu Asn Pro 
            820                 825                 830         


Glu Arg Phe Ala Ala Trp Tyr Ser Tyr Gly Tyr Thr Tyr Ser Gly Lys 
        835                 840                 845             


Phe Gln Ser Phe Tyr Asp Met Pro Arg Asn Tyr Ser Asp Trp Tyr Lys 
    850                 855                 860                 


Lys Leu Lys Glu Asp Gly Lys Leu Pro Arg Leu Asp Lys Lys Thr Glu 
865                 870                 875                 880 


Gln Glu Lys Ile Leu Arg Phe Arg Met Asp Cys Asp Leu Asn Ile Lys 
                885                 890                 895     


His Ile Arg Phe Gln Asp Ile Tyr Val Lys Leu Met Val Asp Ser Leu 
            900                 905                 910         


Tyr Lys Ala Val Phe Gly Gln Gln Pro Glu Phe Asp Leu Ser His Leu 
        915                 920                 925             


Tyr Asp Thr Arg Ser Glu Arg Tyr Glu Asn Asn Thr Ile Ala Gln Arg 
    930                 935                 940                 


Gln Lys Ser Arg Gln Glu Gly Asp Asn Ser Asp Asn Ala Ile Asn Glu 
945                 950                 955                 960 


Asn Tyr Val Trp Asn Lys Thr Phe Ala Ile Ser Leu Tyr Asn Gly Arg 
                965                 970                 975     


Ile Thr Glu Ser Gln Val Lys Leu Lys Asp Val Gly Lys Phe Arg Arg 
            980                 985                 990         


Phe Ala Thr Asp Pro Arg Val Gln  Thr Leu Ile Ser Tyr  Asp Asp Thr 
        995                 1000                 1005             


Arg Thr  Trp Thr Lys Leu Glu  Ile Glu Asn Glu Leu  Asp Asn Lys 
    1010                 1015                 1020             


Ala Asp  Ala Tyr Glu Pro Ile  Arg Arg Thr Gln Ser  Leu Lys Ala 
    1025                 1030                 1035             


Ile Gln  Gln Leu Glu Lys Asn  Ile Leu Lys Lys Asn  Gly Phe Asn 
    1040                 1045                 1050             


Gly Lys  Gln His Pro Glu Glu  Leu Lys His Asn Gly  Asn Pro Asn 
    1055                 1060                 1065             


Phe Arg  Lys Tyr Ile Ala Asn  Gly Leu Leu Lys His  Arg Thr Asp 
    1070                 1075                 1080             


Ile Arg  Gln Glu Glu Leu Ala  Leu Ile Ser Asp Thr  Glu Phe Gln 
    1085                 1090                 1095             


Glu Ile  Gly Leu Glu Arg Ile  Arg Gln Thr Asn Pro  Leu Ile Gln 
    1100                 1105                 1110             


Lys Ala  Tyr Leu Leu Ile Leu  Leu Arg Asn Lys Phe  Gly His Asn 
    1115                 1120                 1125             


Gln Leu  Pro Asp Gln Glu His  Phe Arg Leu Met Arg  Ser Ile Tyr 
    1130                 1135                 1140             


Pro Tyr  Asn Gln Gln Glu Ser  Tyr Ser Ala Tyr Phe  Asn His Val 
    1145                 1150                 1155             


Ile Thr  Gln Ile Ile Glu Glu  Leu Asn Thr 
    1160                 1165             


<210>  2416
<211>  1160
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2416

Met Glu Gln Lys Gln Leu Glu Ser Arg Phe Asn Gln Ile Phe Asn Asn 
1               5                   10                  15      


Lys Gly His Thr Gly Pro Ile Ala Glu Lys Ala Val Lys Asn Phe Glu 
            20                  25                  30          


Thr Ile Arg Gln His Lys Val Ser Pro Arg Glu Arg Leu His Tyr Phe 
        35                  40                  45              


Ala Val Gly His Ala Leu Arg Asn Ile Asp Lys Asp Leu Lys Glu Ser 
    50                  55                  60                  


Ile Phe Glu Tyr Asn Leu Asp Glu Glu Gln Lys Lys Gln Lys Pro Thr 
65                  70                  75                  80  


Gln Phe Thr Thr Leu Gln Ser Asp Phe Phe Arg Phe Glu Asn Ala Leu 
                85                  90                  95      


Leu Thr Leu Leu Lys Asp Ile Arg Asn Cys Asn Gly His Tyr Val His 
            100                 105                 110         


Thr Phe Asp Lys Leu Gln Leu Asp Glu Ile Leu Lys Leu Gln Glu Lys 
        115                 120                 125             


Asn Lys Glu His Gly Ile Leu Asn Lys Asp Ala Gly Cys Gln Ile Ile 
    130                 135                 140                 


Glu Phe Leu Lys Glu Ala Phe Glu Phe Ser Ile Leu Ile Gln Phe Leu 
145                 150                 155                 160 


Lys Glu Lys Pro Lys Glu Tyr Glu Lys Phe Lys Lys Arg Lys Asn Glu 
                165                 170                 175     


Asn Lys Asn Gln Ser Leu Arg Asn Leu Ile Gly Gly Tyr Glu Lys Lys 
            180                 185                 190         


Leu Val Lys Tyr Leu Cys Asp Lys Phe Phe Pro Asn Glu Glu Lys Gln 
        195                 200                 205             


Lys Glu Ile Arg Asp Lys Phe Ile Glu His Asn Leu Glu Glu Ala Ile 
    210                 215                 220                 


Glu Asp Leu Leu Phe Ile Pro Val Asp Glu Asp Ile Glu Trp Lys Leu 
225                 230                 235                 240 


Gly Glu Glu His Val Val Phe Val Ile Lys Lys Gly Lys Tyr Leu Ser 
                245                 250                 255     


Phe Tyr Ala Gln Leu Phe Leu Leu Ser Met Phe Leu Tyr Lys Gln Glu 
            260                 265                 270         


Ala Asn Gln Leu Ile Ser Lys Ile Arg Gly Phe Lys Arg Ser Glu Asp 
        275                 280                 285             


Glu Phe Gln Tyr Lys Arg Asn Ile Phe Thr Phe Phe Ser Lys Lys Val 
    290                 295                 300                 


Ser Ser Gln Asp Ile His Ser Glu Glu Lys His Leu Ile Tyr Phe Arg 
305                 310                 315                 320 


Asp Ile Ile Gln Tyr Leu Asn Arg Phe Pro Thr Ala Trp Asn Glu Tyr 
                325                 330                 335     


Leu Ser Pro Glu Arg Lys Asn Leu Pro Met Thr Lys Leu Leu Glu Lys 
            340                 345                 350         


Tyr Ile Leu Glu Glu Glu Ile Phe Arg Thr Phe Ser Thr Tyr Lys Asn 
        355                 360                 365             


Asp Cys Asn Arg Glu Leu Phe Leu Lys Tyr Thr Ile Lys Arg Leu Phe 
    370                 375                 380                 


Arg Lys Lys Ala Glu Leu Phe Asp Ala Glu Lys Ile Ser Ile Asp Asp 
385                 390                 395                 400 


Asn Leu Arg Lys Lys Phe Asn Tyr Glu Ile Asp Thr Ser Pro Glu Leu 
                405                 410                 415     


Lys Asn Ile His Glu Lys Leu Lys Gly Lys Leu Lys Pro Lys Asp Tyr 
            420                 425                 430         


Tyr Lys Asn Ile Lys Arg Lys Glu Glu Leu Glu Lys Glu Glu Asn Pro 
        435                 440                 445             


Glu Lys Leu Lys Leu Ile Lys Lys Val Thr Glu Glu Lys Leu Phe Thr 
    450                 455                 460                 


Ala Tyr Gly Arg Asn Arg Asp Arg Phe Met Asp Phe Ala Val Arg Tyr 
465                 470                 475                 480 


Leu Ala Glu Gln Asn Tyr Phe Gly Lys Asp Ala Glu Phe Lys Met Tyr 
                485                 490                 495     


Met Phe Glu Thr Thr Asn Glu Gln Glu Asn Tyr Leu Lys Glu Gln Lys 
            500                 505                 510         


Asn Thr Ala Asp Lys Lys Val Ile Asp Gln Asn Lys Tyr His Gln Gly 
        515                 520                 525             


Arg Leu Thr Cys Phe Lys Thr Tyr Gln Lys His Lys Asp Asp Tyr Gln 
    530                 535                 540                 


Asn Trp Asp Asp Pro Phe Val Phe Gln Asn Asn Ala Phe Gln Ile Val 
545                 550                 555                 560 


Leu Thr Phe Ser Asn Gly Glu Arg Lys Lys Phe Ser Ile Gln Arg Lys 
                565                 570                 575     


Leu Leu Ile Tyr Leu Leu Glu Asp Ala Leu Phe Asn His Ser Asp Ser 
            580                 585                 590         


Ile Glu Asp Lys Gly Lys Gln Leu Leu Glu Asp Tyr Phe Phe Asn Thr 
        595                 600                 605             


Leu Met Pro Asp Phe Glu Glu Ala Lys Gly Ser Tyr Lys Thr Ser Asp 
    610                 615                 620                 


Asp Val Asn Trp Lys His Arg Lys Leu Leu Pro Lys Arg Leu Ile Tyr 
625                 630                 635                 640 


Thr Val His Pro Pro Arg Arg Thr Asp Ser Glu Glu Gln Ile His Pro 
                645                 650                 655     


Phe Glu Lys Ile Leu Arg Glu Thr Gln Glu Gln Glu Arg Arg Tyr Arg 
            660                 665                 670         


Leu Leu Leu Gly Lys Ala Lys Asn Met Lys Leu Lys Glu Glu Phe Ile 
        675                 680                 685             


Lys Arg Asn Lys Gly Lys His Phe Lys Leu Arg Phe Ile Arg Lys Ala 
    690                 695                 700                 


Trp His Leu Met Tyr Phe Arg Glu Ile Tyr Glu Arg Arg Ala Lys Glu 
705                 710                 715                 720 


His Ser His His Lys Ser Phe His Ile Thr Arg Asp Glu Ile Asn Asp 
                725                 730                 735     


Phe Ser Arg Trp Met Tyr Ala Phe Asp Glu Val Pro Pro Tyr Lys Val 
            740                 745                 750         


Tyr Leu Arg Asn Met Leu Gln Arg Lys Lys Phe Met Glu Asn Glu Glu 
        755                 760                 765             


Phe Ala Glu Leu Phe Glu Lys Gly Lys Ser Leu Asp Glu Phe Tyr His 
    770                 775                 780                 


Leu Thr Lys Gln Glu Phe Ser Lys Arg Ile Lys Asn Asn Leu Phe Gln 
785                 790                 795                 800 


Leu Lys Val Asp Ser Glu Arg Gln Tyr Ala Glu Val Leu Ser Lys Lys 
                805                 810                 815     


Leu Val Tyr Ile Asn Leu Ser His Phe Ile Lys Tyr Leu Asn Ala Lys 
            820                 825                 830         


Gly Lys Leu Thr Val Glu Asn Gly Ile Ile Gln Tyr Lys Ala Ser Thr 
        835                 840                 845             


Asn Lys Lys Tyr Leu Ile Asp Glu Tyr Tyr Tyr Thr Glu Val Leu Pro 
    850                 855                 860                 


Arg Glu Glu Tyr Lys Val His Lys His Leu Phe Asn Lys Leu Arg Ala 
865                 870                 875                 880 


Ala Lys Leu Glu Asp Ala Leu Leu Tyr Glu Leu Ala Met Lys Tyr Leu 
                885                 890                 895     


Lys Glu Asp Glu Glu Ile Val Glu Lys Ala Lys Ser Lys Val Ser Asp 
            900                 905                 910         


Ile Gln Ser Ser Glu Ile Ser Phe Asp Ile Lys Asp Tyr Tyr Gly Asn 
        915                 920                 925             


His Leu Tyr Thr Leu Ile Val Pro Phe Asn Lys Leu Glu Thr Leu Ser 
    930                 935                 940                 


Ile Leu Ile Arg Tyr Lys Thr Gly Gln Glu Asn Glu Leu Lys Asn Lys 
945                 950                 955                 960 


Lys Thr Ser Phe Leu Gly Asn Ile Tyr His Leu Leu Ala Phe Leu Asp 
                965                 970                 975     


Lys Asn Tyr Lys Gln Leu Ser Lys Tyr Lys Asp Asp Gly Gly Phe Lys 
            980                 985                 990         


Lys Ile Val Lys Asn Phe Lys Asn  Lys Lys Arg Leu Ser  Phe Val Glu 
        995                 1000                 1005             


Leu Asn  Thr Ile Asn Gly Tyr  Ile Ile Ser Gly Ala  Val Lys Phe 
    1010                 1015                 1020             


Ser Lys  Val His Met Glu Leu  Glu Arg Tyr Phe Ile  Asn Lys His 
    1025                 1030                 1035             


Lys Ile  Lys Ala Asn His Ile  Tyr Ile Asp Leu Glu  Asp Ile Lys 
    1040                 1045                 1050             


Asp Asp  Ser Asn Lys Gln Val  Phe Gly Asn Tyr Tyr  Asp Ser Lys 
    1055                 1060                 1065             


Leu Arg  Ile Arg Asn Lys Ala  Phe His Phe Gly Val  Pro Thr Asn 
    1070                 1075                 1080             


Phe Phe  Phe Asn Ile Glu Ile  Glu Lys Ile Glu Lys  Lys Phe Ile 
    1085                 1090                 1095             


Leu Glu  Glu Val Lys Leu Gln  Asn Val Ser Ser Phe  Asp Lys Leu 
    1100                 1105                 1110             


Asn Gln  Asn Ala Lys Ser Val  Cys Arg Val Phe Met  Glu Val Leu 
    1115                 1120                 1125             


His Ser  Asp Leu Tyr Arg Arg  Asp Lys Asn Lys Ser  Lys Glu Glu 
    1130                 1135                 1140             


Leu Arg  Arg Glu Phe Glu Glu  Lys Tyr Phe Asn Glu  Ile Ile Thr 
    1145                 1150                 1155             


Thr Val  
    1160 


<210>  2417
<211>  1144
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2417

Met Asn Asn Leu Cys Asn Gln Ser Pro Arg Glu Val Tyr Asn Leu Lys 
1               5                   10                  15      


Asp Ser Pro Trp Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg His Asn 
            20                  25                  30          


Ile Tyr Leu Ile Ser Asn Glu Ile Ser Asp Lys Leu Ser Leu Lys His 
        35                  40                  45              


Pro Leu Ser Asn Glu Glu Ile Ile Glu Lys Ser Phe Leu Thr Asp Lys 
    50                  55                  60                  


Asp Phe Trp Asn Lys Asn Asn Pro Arg Leu Ile Leu Ser Ala Leu Ser 
65                  70                  75                  80  


Arg Phe Met Pro Val Val Lys Thr Tyr Ser Ser Asp Leu Leu His Lys 
                85                  90                  95      


Glu Leu Arg Glu Gln Thr Asp Ile Glu Gly Thr Asp Ile Ala Gly Leu 
            100                 105                 110         


Val Glu Phe Leu Arg Leu Ser Phe Lys Glu Leu Asn Ala Phe Arg Asn 
        115                 120                 125             


Asp Tyr Ser His Tyr Tyr Ser Ser Lys Thr Tyr Asp Lys Arg Lys Val 
    130                 135                 140                 


Val Val Ala Glu Asp Phe Ala Ile Met Leu Arg Lys Gln Phe Gln Leu 
145                 150                 155                 160 


Ala Val Ser Ile Ala Arg Lys Arg Phe Glu Gly Val Ile Pro Ser Gln 
                165                 170                 175     


Ser Phe Asp Phe Val Glu Lys Lys Ile Ala Glu Glu Leu Phe Asn Asp 
            180                 185                 190         


Ser Thr Thr Ile Thr Thr Arg Gly Leu Val Phe Phe Thr Cys Leu Phe 
        195                 200                 205             


Leu Asp Lys Glu Asn Ala Phe Gln Phe Phe Asn Arg Val Ser Gly Phe 
    210                 215                 220                 


Lys Asp Thr Arg Thr Tyr Asp Phe Leu Ala Thr Arg Glu Val Phe Thr 
225                 230                 235                 240 


Val Phe Cys Val Lys Leu Pro His Asp Lys Phe Val Ser Glu Asn Pro 
                245                 250                 255     


Gln Gln Ala Leu Gln Leu Asp Ile Leu Asn Tyr Leu Asn Arg Ala Pro 
            260                 265                 270         


Lys Glu Leu Tyr Asn Ser Leu Thr Glu Glu Gly Lys Lys Ile Phe Lys 
        275                 280                 285             


Pro Asp Leu Ser Glu Phe Ala Lys Ile Asn Ile Ala Glu Asn Ser Ile 
    290                 295                 300                 


Asn Glu Thr Ile Ala Asp Tyr Asp Tyr Asp Glu Tyr Ile Gln Ala Ile 
305                 310                 315                 320 


Thr Thr Lys Thr Arg Ser Glu Asp Arg Phe Pro Glu Phe Ala Leu Arg 
                325                 330                 335     


Tyr Leu Asp Gln Ser Asp Ala Phe Gln Tyr His Phe His Ile His Leu 
            340                 345                 350         


Gly Lys Val Ile Thr Asn Lys Tyr Pro Lys Pro Phe Leu Gly Glu Ser 
        355                 360                 365             


Pro Asp Glu Asp Asn Arg Asn Ile Glu Lys Ser Ile Lys Thr Phe Gly 
    370                 375                 380                 


Glu Leu Thr Ala Phe Leu Lys Pro His Gln Thr Asp Thr Glu Gly Val 
385                 390                 395                 400 


Lys Asn Ser Ile Ile Gln Glu Asp Glu Phe Lys Lys Leu Phe Gln Glu 
                405                 410                 415     


Gln Gly Leu Val Gly Phe Thr Gln Tyr Ala Pro His Tyr His Ile Gln 
            420                 425                 430         


Asn Asn Lys Ile Gly Leu Leu Asp Lys Leu Asn Glu Gln Val Ser Lys 
        435                 440                 445             


Leu Pro Cys Asn Leu Tyr Arg Pro Leu Pro Pro Val Ala Phe Leu Ser 
    450                 455                 460                 


Ile His Glu Leu Pro Lys Val Val Leu Leu Glu Ile Leu Ala Lys Gly 
465                 470                 475                 480 


Lys Ala Ser Lys Leu Ile Thr Asp Phe Leu Gln Lys Asn Lys Glu Leu 
                485                 490                 495     


Ile Tyr Asn Arg Asp Phe Ile Glu Asp Ile Lys Lys Gln Leu Asp Phe 
            500                 505                 510         


Lys Pro Leu Gln Lys Leu Phe Phe Asp Glu Lys Ser Pro Lys Leu Val 
        515                 520                 525             


Asn Asn Glu Glu Thr Glu Arg Lys Ile Glu Glu Thr Gln Asn Gln Leu 
    530                 535                 540                 


Lys Gln Ser Ile Pro Glu Lys Gln Lys Val Lys Leu Lys Ser Thr Leu 
545                 550                 555                 560 


Lys Ser Leu Ile Tyr Ala Arg Tyr Val Asn Glu Val Asn Glu Arg Lys 
                565                 570                 575     


Ala Lys Leu Asn Leu Leu Leu Ala Glu Arg Lys Leu Asp Ala Asn Gln 
            580                 585                 590         


Ile Pro Gly Arg Ile Ile Glu Tyr Trp Leu Asn Ile Asp Ser Val Lys 
        595                 600                 605             


Lys Glu His Ser Ile Gln Asn Arg Ile Lys Ala Glu Arg Lys Glu Cys 
    610                 615                 620                 


Lys Asn Arg Ile Lys Asp Leu Asp Lys Gly Lys Ala Pro Lys Ile Gly 
625                 630                 635                 640 


Glu Met Ala Thr Phe Leu Ala Arg Asp Ile Val Lys Leu Val Ile Asn 
                645                 650                 655     


Lys Asp Val Lys Lys Lys Ile Thr Ser Phe Tyr Tyr Asn Leu Leu Gln 
            660                 665                 670         


Glu Cys Leu Ala Leu Tyr Ala Asp Pro Thr Lys Arg Gln Leu Leu Leu 
        675                 680                 685             


Asp Leu Cys Gly Lys Lys Leu Asn Leu Phe Asn Lys Glu Ile Gly His 
    690                 695                 700                 


Pro Phe Leu Ala Asp Ile Asn Phe Gly Glu Ile Thr Lys Thr Lys Asp 
705                 710                 715                 720 


Leu Tyr Arg Lys Tyr Leu Glu Leu Lys Gly Ala Gly Lys Lys Val Glu 
                725                 730                 735     


Lys Lys Tyr Asn Arg Lys Thr Asn Arg Phe Glu Glu Ile Glu Lys Glu 
            740                 745                 750         


Asp Asp Trp Ile Tyr Asn Thr Phe Tyr Phe Val Lys Lys Asp Pro Ile 
        755                 760                 765             


Thr Asn Lys Glu Phe Thr Lys Ile Lys Leu Pro Glu Ser Asn Val Pro 
    770                 775                 780                 


Leu Ser Tyr Leu Arg Phe Asn Gln Asp Lys Thr Ser Phe Asp Phe Trp 
785                 790                 795                 800 


Leu Asn Ser Val Ser Lys Gly Asn Asn Lys Asn Pro Asn Pro Lys Pro 
                805                 810                 815     


Val Asp Leu Pro Thr Asn Leu Phe Asp Asn Val Leu Ile Ser Ile Leu 
            820                 825                 830         


Lys Arg Lys Val Glu Ile Ser Asp Asp Thr Lys Tyr Asn Tyr Ser Lys 
        835                 840                 845             


Leu Leu Ala Leu Trp Leu Lys Glu Thr Gln Pro Tyr Tyr His Leu Lys 
    850                 855                 860                 


Arg Glu Tyr Thr Ile Phe Lys Asp Lys Pro Tyr Gln Thr Ile Val Glu 
865                 870                 875                 880 


Phe Asp Pro Asn Glu Asn Lys Pro Phe Lys Glu Tyr Tyr Ala Asn Ser 
                885                 890                 895     


Val Glu His Ala Phe Arg Lys Arg Lys Arg Glu Glu Lys Arg Ile Gln 
            900                 905                 910         


Lys Arg Gln Ile Ala Thr Val Phe Lys Lys Ala Ile Glu Asp Asn Glu 
        915                 920                 925             


Lys Val Ile Arg Phe Tyr Gln Thr Lys Asp Arg Ile Thr Leu Leu Met 
    930                 935                 940                 


Leu Asn Glu Leu Met Gly Lys Asp Leu Gln Ile Ser Leu Asn Glu Leu 
945                 950                 955                 960 


Ser Pro Asp Ser Asp Lys Ser Pro Leu Glu Ala His Ile Thr Ile Cys 
                965                 970                 975     


Glu Lys Ile His Gly Lys Thr Ile Thr Asp Arg Arg Lys Arg Lys Asp 
            980                 985                 990         


Phe Ser Val Phe Arg Lys Leu Ile  Ser Asp Arg Arg Leu  Lys His Leu 
        995                 1000                 1005             


Phe Asp  Tyr Tyr Ser Ser Glu  Thr Ile Pro Tyr Glu  Val Leu Arg 
    1010                 1015                 1020             


Glu Glu  Leu Asn Asp Tyr Asp  Arg Cys Lys Glu Lys  Val Phe Lys 
    1025                 1030                 1035             


Ala Ala  Phe Asp Leu Glu Lys  Ala Ile Ile Asn Val  Ala Ser Lys 
    1040                 1045                 1050             


Glu Glu  Tyr Gln Lys Ile Val  Glu Asp Gly Thr Lys  Tyr Gly Ala 
    1055                 1060                 1065             


Asn Ile  Gln His Arg Pro Tyr  Leu Asp Trp Leu Thr  Ser His Asn 
    1070                 1075                 1080             


Ala Ile  Ser Lys Ile Glu Glu  Lys Phe Leu Leu Glu  Val Arg Asn 
    1085                 1090                 1095             


Arg Phe  Ser His Asn Glu Tyr  Pro Lys Lys Asp Ile  Val Thr Lys 
    1100                 1105                 1110             


Tyr Ile  Pro His Phe Ala Asn  Ser Thr Ile Ser Ser  Lys Ile Val 
    1115                 1120                 1125             


Ala Thr  Tyr Val Glu Ile Val  Asn Arg Leu Ile Thr  Thr Ile Leu 
    1130                 1135                 1140             


Arg 
    


<210>  2418
<211>  1087
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2418

Met Glu Ala Lys His Glu Thr Gln Tyr Phe Asp Phe Thr Asn Lys Glu 
1               5                   10                  15      


His Lys His Phe Phe Ala Gly Leu Phe Asn Thr Ala Gln His His Phe 
            20                  25                  30          


Asp Leu Ser Leu Thr Glu Leu Ala Asp Arg Ile Asn Glu Lys Gly Lys 
        35                  40                  45              


Thr Gly Lys Gly Phe Ile Lys Glu Ala Phe Ser Asp Ala Ile Ser Glu 
    50                  55                  60                  


Ala Asp Trp Glu Thr Arg Ile Asn Tyr Leu Ser Glu Ser Leu Thr Phe 
65                  70                  75                  80  


Ile Asn Tyr Phe Asp Tyr Asp Cys Arg Thr Ala Phe Arg Glu Ile Met 
                85                  90                  95      


Leu Leu Leu Tyr Asp Thr Ile Thr Asn Tyr Arg Asn Tyr Tyr Ser His 
            100                 105                 110         


Tyr Gln His Lys Lys Val Ala Leu Asp Asp Ala Ile Phe Pro Phe Leu 
        115                 120                 125             


Asp Glu Leu Leu Phe Lys Ser Ala Leu Asn Val Lys Arg Asn Arg Ala 
    130                 135                 140                 


Lys Ser Glu Ile Tyr Lys Ala His Leu Ser Val Lys Tyr Lys Ser Glu 
145                 150                 155                 160 


Phe Asp Lys Ile Ile Ala Lys Ser Asn Glu Lys Ile Glu Ala Tyr Asn 
                165                 170                 175     


Ala Gln Leu Lys Lys Gly Glu Lys Lys Arg Ala Phe Ile Lys Gln Lys 
            180                 185                 190         


Asp Glu Val Asn His Val Leu Asn Gln Val Phe Arg Ser Phe Leu Tyr 
        195                 200                 205             


Lys Asn Asp Asn Gly Glu Glu Thr Leu Ser Glu Tyr Ala Leu Ser Lys 
    210                 215                 220                 


Thr Asp Glu Gly His Leu Ser Thr Tyr Gly Phe Val Gln Leu Ala Ala 
225                 230                 235                 240 


Leu Phe Leu Ser Lys Lys Gln Thr Glu Ser Leu Leu Asn Tyr Thr Lys 
                245                 250                 255     


Tyr Leu Lys Asp Thr Arg Glu Leu Arg Phe Val Ser Ser Arg Trp Thr 
            260                 265                 270         


Phe Thr Phe Leu Cys Tyr Arg Asp Ile Lys Arg Leu Phe Arg Ser Asp 
        275                 280                 285             


Tyr Ser Asn Asp Ser Leu Leu Leu Gln Met Ile Ser Glu Leu Asn Lys 
    290                 295                 300                 


Cys Pro Asp Ala Leu Tyr Gln His Leu Ser Pro Glu Lys Lys Gln Glu 
305                 310                 315                 320 


Phe Leu Glu Asp Ile Asn Thr Tyr Tyr Lys Asp Asn Ser Glu Phe Phe 
                325                 330                 335     


Gly Thr Gln Glu Lys Ala Leu Val Ser His Glu Val Leu Gln Lys Arg 
            340                 345                 350         


Tyr Ser Asn Lys Phe Ala Tyr Phe Ala Leu Arg Phe Leu Asp Glu Val 
        355                 360                 365             


Cys Asn Phe Pro Thr Leu Arg Phe Ser Ile Asn Leu Gly Lys Phe Asn 
    370                 375                 380                 


His Asp Thr Ser Pro Lys Thr Phe Asn Ser Lys Val Ile Thr Glu Arg 
385                 390                 395                 400 


Ser Leu Leu Glu Lys Ile Thr Val Phe Thr Lys Leu Ser Glu Ala Thr 
                405                 410                 415     


Asp Ala Lys Lys Ala Tyr Phe Lys Asn Pro Glu Asn Ile Asp Leu Val 
            420                 425                 430         


His Asp Trp Leu Glu Phe Pro Met Pro Ser Tyr Gln Phe Asn Arg Asn 
        435                 440                 445             


Asn Ile Gly Ile Trp Leu Ala Ile Asn Asp Asp Ser Gly Lys Ser Asp 
    450                 455                 460                 


Ala Ala Thr Lys Arg Asn Arg Glu Asp Lys Lys Thr Lys Tyr Ala Ile 
465                 470                 475                 480 


Ala Glu Lys Leu Gly Leu Thr Asp Thr Val Lys Lys Pro Ile Ala Phe 
                485                 490                 495     


Leu Ser Ser Asn Glu Leu Pro Ala Leu Leu Tyr Ala Leu Leu Ile Glu 
            500                 505                 510         


Asn Lys Thr Pro Asn Asp Val Glu Ser Leu Leu Arg Lys Lys Ile Gln 
        515                 520                 525             


Ile Gln Arg Gly Leu Leu Asp Lys Phe Gly Lys Arg Glu Leu Val Asn 
    530                 535                 540                 


Arg Lys Val Phe Pro Lys Lys Leu Leu Gln Ser Arg Asp Lys Leu Thr 
545                 550                 555                 560 


Phe Asp Ile Glu Lys Leu Lys Gln Asn Ile Thr Thr Glu Ile Lys Lys 
                565                 570                 575     


Asn Pro Leu Lys Asp Ile Arg Lys Lys Tyr Lys Lys Lys Pro Lys Glu 
            580                 585                 590         


Pro Asn Glu Leu Thr Asn Lys Glu Lys Gly Asn Ile Ala Thr Trp Leu 
        595                 600                 605             


Ala Asp Asp Ile Lys Arg Phe Thr Ser Lys Ala Thr Lys Lys Asp Trp 
    610                 615                 620                 


Lys Gly Tyr Gln Tyr Ala Glu Phe Gln Ala Leu Leu Ser Phe Tyr Asp 
625                 630                 635                 640 


Ile Asp Lys Glu Lys Pro Lys Ser Phe Leu Glu Gln Asp Leu His Tyr 
                645                 650                 655     


His Phe Lys Ile Asp Asn Pro Phe Gly Gly Val Asn Phe Asn His Lys 
            660                 665                 670         


Ser Leu Tyr Thr Phe Tyr Asn Thr Tyr Leu Lys Lys Arg Glu Lys Tyr 
        675                 680                 685             


Leu Glu Asp Leu Thr Lys Thr Ile Asp Ala Asn Tyr Gly Asp Ile Pro 
    690                 695                 700                 


Glu Thr Val Phe Ile Gly Phe Thr Lys Arg Ile Tyr Glu Ile Lys Pro 
705                 710                 715                 720 


Val Glu Ile Gln Lys Asp Thr Leu Leu Asn Lys Ile Pro Ile Asn Leu 
                725                 730                 735     


Pro Arg Gly Ile Phe Asp Asp Lys Pro Thr Ser Tyr Asp Lys Lys Glu 
            740                 745                 750         


Lys Pro Val Ala Leu Ala Gly Trp Phe Glu Lys Ser Asn Gln Leu Glu 
        755                 760                 765             


Asn Ala Gln Arg Phe Tyr His Phe Glu Lys Val Tyr Glu Tyr Pro Ile 
    770                 775                 780                 


Thr Val Leu Lys Trp Asn Pro Lys Lys Arg Lys Lys Glu Glu Lys Ile 
785                 790                 795                 800 


Val Leu Lys Glu Gln Ser Ile Asn Pro Asn Lys Gly Leu Lys Glu Gln 
                805                 810                 815     


Tyr Tyr Glu Asn Leu Pro Val Lys Asn Gln Arg Glu Ile Tyr Asn Asn 
            820                 825                 830         


Glu Lys Arg Ile Arg Lys Ile Met Arg Gln Asp Phe Phe Val Leu Glu 
        835                 840                 845             


Met Ala Lys His Leu Leu Gln Lys Ala Lys Val Lys Gly Leu Asp Asp 
    850                 855                 860                 


Leu Gln Leu Lys Asp Ile Phe Leu Thr Lys Lys Glu Lys Asn Lys Ile 
865                 870                 875                 880 


Gln Glu Glu Ser Lys Lys Gln Ser Glu Arg Asn Thr Gly Asp Thr Ser 
                885                 890                 895     


Lys Asn Ser Ile Thr Asp Ser His Ile Leu Ser Arg Lys Ile Glu Ile 
            900                 905                 910         


Ser Ile Leu Asp Gly Arg Val Lys Gly Thr Pro Lys Ile Lys Asp Val 
        915                 920                 925             


Gly Lys Cys Arg Lys Phe Glu Thr Asp Ala Arg Val Lys Glu Leu Val 
    930                 935                 940                 


Asn Tyr Phe Cys Asp Lys Thr Trp Ser Phe Thr Glu Ile Gln Asn Glu 
945                 950                 955                 960 


Ile Asp Asp Phe Asp Arg Val Arg Lys Phe Glu Leu Phe Lys Ser Val 
                965                 970                 975     


His Gln Leu Glu Lys Lys Ile Tyr Glu Asp Ala Thr Lys Lys Asn Cys 
            980                 985                 990         


Thr Asp Ala Leu Leu Asn Gln Gly  Asn Pro Ser Phe Lys  Arg Tyr Val 
        995                 1000                 1005             


Ser His  Tyr Phe Leu Glu Thr  Asp Lys Glu Ala Phe  Asn Asn Leu 
    1010                 1015                 1020             


Pro Ile  Lys Ile Ile Ser Ala  Thr Pro Glu Trp Gln  Lys Phe Phe 
    1025                 1030                 1035             


Leu Leu  Ala Lys Ile Arg Asn  Lys Phe Ser His Asn  Gln Phe Leu 
    1040                 1045                 1050             


Pro Thr  Glu Asp Phe Lys Lys  Leu Met Glu Phe Val  Pro Leu Glu 
    1055                 1060                 1065             


Lys Asp  Glu Leu Ile Ala Thr  Tyr Leu Asn Arg Ala  Phe Ile Glu 
    1070                 1075                 1080             


Leu Gln  Lys Arg 
    1085         


<210>  2419
<211>  1000
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2419

Met Glu Glu Ala Asn Arg Tyr Ile Tyr Gly Ala Tyr Phe Asn Met Ala 
1               5                   10                  15      


Arg Asp Asn Phe Leu Asn Thr Ile Lys Leu Leu Ala Asp Lys Met Lys 
            20                  25                  30          


Leu Gly Ala Thr Ser Gly Phe Gly Lys Asp Gly Asn Glu Val Asn Asp 
        35                  40                  45              


Ile Asn Glu Leu Phe Gly Asp Lys Asn Thr Tyr Ala Asn Ile Glu Asn 
    50                  55                  60                  


Val Val Glu Phe Tyr Phe Pro Trp Ile Lys Ala Leu Glu Gly Arg Phe 
65                  70                  75                  80  


Ser Leu Asp Lys Gly Asp Arg Asn Leu Asn Asp Met Lys Met Phe Tyr 
                85                  90                  95      


Lys Ser Val Leu Thr Ala Phe Phe Thr Ala Val Asp Ser Leu Arg Asn 
            100                 105                 110         


Lys Tyr Thr His Tyr Ser His Lys Asp Leu Asn Ile Arg Glu Ile Lys 
        115                 120                 125             


Ile Glu Cys Thr Leu Gly Gly Lys Asp Tyr Cys Ile Gly Leu Leu Asn 
    130                 135                 140                 


Ala Leu Asp Cys Ile Tyr Asp Ser Ala Val Asn Leu Leu Lys Leu Arg 
145                 150                 155                 160 


Phe Met Ala Asp Glu Asp Glu Val Ala His Leu Arg Arg Cys Lys Ala 
                165                 170                 175     


Val Asn Lys Lys Val Val Val Arg Thr Glu Lys Asp Gly Phe Tyr Tyr 
            180                 185                 190         


Arg Leu Ser Asp Asn Gly Glu Val Thr Glu Lys Gly Val Ile Phe Ile 
        195                 200                 205             


Ala Ser Met Phe Leu Asn Arg Lys Tyr Gly Phe Leu Phe Leu Lys Gln 
    210                 215                 220                 


Leu Glu Gly Phe Lys Arg Ser Asp Glu Lys Arg Tyr Arg Leu Thr Leu 
225                 230                 235                 240 


Glu Ala Phe Leu Ala Phe Ser Asn Ile Lys Pro Val Asp Arg Leu Lys 
                245                 250                 255     


Ser Asp Lys Leu Asp Arg Ala Ser Leu Gly Leu Asp Met Leu Asn Glu 
            260                 265                 270         


Leu Thr Lys Ile Pro Lys Glu Leu Ser Glu Thr Leu Ser Val Asp Cys 
        275                 280                 285             


Leu Tyr Lys Tyr Leu Ala Ser Asp Gly Glu Asp Asp Leu Arg Ser Arg 
    290                 295                 300                 


Ile Arg Tyr Gln Asp Arg Phe Val Pro Leu Ala Leu Glu Phe Ile Ser 
305                 310                 315                 320 


Gln Ser Asp Glu Phe Lys Asp Phe Arg Phe Tyr Thr Tyr Val Gly Asn 
                325                 330                 335     


Tyr Val Tyr Lys Gly Tyr Ile Lys Arg Leu Ile Asp Gly Thr Asp Lys 
            340                 345                 350         


Glu Arg Tyr Leu Ser Asp Arg Leu Cys Gly Phe Tyr Lys Ser Val Asn 
        355                 360                 365             


Asp Ala Ser Ser Asp Ala Ile Ala Gln Lys Tyr Gly Val Glu Ile Lys 
    370                 375                 380                 


Asp Ser Asn Glu Pro Asp Tyr Met Leu Pro Asp Ser Phe Arg Pro His 
385                 390                 395                 400 


Val Leu Arg Ala Thr Pro His Phe Val Ile Asn Asn Asn Asn Ile Gly 
                405                 410                 415     


Ile Lys Ile Cys Gly Asn Asp Cys Leu Pro Val Val Asn Gly Lys Gly 
            420                 425                 430         


Val Glu Ser Pro Glu Pro Asp Tyr Trp Leu Ser Ile Tyr Glu Leu Pro 
        435                 440                 445             


Ala Met Leu Phe Tyr Ala Tyr Leu Arg Glu Lys Asn Gly Lys Leu Leu 
    450                 455                 460                 


Lys Asp Tyr Lys Ser Ile Arg Glu Leu Ile Glu Asp Val Glu Lys Lys 
465                 470                 475                 480 


Ala Asp Glu Lys Asn Asp Arg Asp Lys Gly Ala Leu Met Ala Arg His 
                485                 490                 495     


Ile Asp Lys Glu Ile Ile Trp Thr Gln Thr Lys Leu Asp Glu Val Lys 
            500                 505                 510         


Arg Leu Glu Glu Lys Lys Val Ala Ala Tyr Gly Lys Lys Gly Arg Val 
        515                 520                 525             


Val Leu Lys Ser Gly Arg Met Ala Asp Leu Leu Ala His Asp Met Val 
    530                 535                 540                 


Arg Leu Gln Pro Ala Thr Lys Gly Ser Asp Lys Ile Thr Gly Ala Asn 
545                 550                 555                 560 


Phe Gln Ala Leu Gln Val Ser Leu Ala Tyr Phe Lys Arg Asp Ile Leu 
                565                 570                 575     


Ala Asp Val Phe Ser Arg Ala Met Leu Thr Thr Gly Asn His Arg His 
            580                 585                 590         


Pro Phe Leu Tyr Arg Ile Asp Val Ser His Cys Ser Ser Leu Arg Asp 
        595                 600                 605             


Phe Tyr Val Ala Tyr Leu Gly Glu Arg Arg Lys Tyr Phe Glu Asp Val 
    610                 615                 620                 


Ala Lys Lys Ile Thr Lys Asn Lys Leu Asn Thr Pro Cys His Ile Leu 
625                 630                 635                 640 


Arg Arg Leu Gln Arg Glu Gly Ser Gly Glu Glu Ala Gly Lys Asp Val 
                645                 650                 655     


Lys Pro Lys Phe Leu Pro Arg Gly Ile Phe Thr Gly Ser Ile Lys Ser 
            660                 665                 670         


Cys Leu Glu Lys Ser Ala Leu Asn Ile Asn Ile Arg Asn Ala Arg Asn 
        675                 680                 685             


Asp Val Lys Pro Ala Ile Asn Ala Ala Tyr Leu Ile Phe Met Tyr Tyr 
    690                 695                 700                 


Lys Glu Ile Glu Lys Gly Glu Phe Gln Gly Phe Tyr Gly Glu Lys Arg 
705                 710                 715                 720 


Arg Tyr Asp Ile Leu Glu Glu Gly Lys Pro Leu Asp Leu Asp Glu Arg 
                725                 730                 735     


Lys Lys Ala Leu Ala Ser Ile Lys Pro Ala Lys Ile Asp Val Ser Glu 
            740                 745                 750         


Ala Asn Met Pro Met Ser Lys Glu Glu His Leu Met Arg Lys Arg Tyr 
        755                 760                 765             


His Ala Val Cys Asn Asn Glu Ser Ala Ile Arg Met Tyr Gln Val Gln 
    770                 775                 780                 


Asp Ile Leu Leu Leu Leu Met Ala Lys Asp Ile Phe Lys Lys Ala Leu 
785                 790                 795                 800 


Ser Glu Val Val Met Ser Lys Lys Ile Gly Leu Glu Asn Leu Asn Gly 
                805                 810                 815     


Ile Phe Asp Ala Pro Val Asn Phe Val Lys Asn Phe Asp Asn Ile Lys 
            820                 825                 830         


Leu Thr Ala Thr Gly Ile Lys Ile Lys Asp Tyr Gly Lys Val Cys Arg 
        835                 840                 845             


Leu Gly Thr Asp Phe Lys Phe Asn Ser Leu Ile Lys Ala Phe His Lys 
    850                 855                 860                 


Val Tyr Ser Lys Ser Val Glu Met Asp Tyr Ser Asp Tyr Leu Lys Glu 
865                 870                 875                 880 


Glu Glu Glu Phe Glu Lys Tyr Arg Leu Asn Met Val Lys Leu Cys Arg 
                885                 890                 895     


Glu Val Glu Arg Gly Ile Thr Glu Asp Leu His Leu Ser Leu Asp Gly 
            900                 905                 910         


Lys Ser His Leu Ser Phe Asn Asp Asp Val Ile Lys Ser Tyr Asn Asp 
        915                 920                 925             


Lys Tyr Asn Val Phe Asn Gly Asp Asp Leu Thr Phe Phe Ile Asn Ala 
    930                 935                 940                 


Arg Asn Met Phe Met His Gly Asp Tyr Lys Tyr Glu Cys Val Lys Tyr 
945                 950                 955                 960 


Val Val Ser Glu His Phe Lys Gly Ser Leu Asn Asp Val Ser Phe Ala 
                965                 970                 975     


Lys Glu Thr Tyr Gly His Phe Cys Asn Leu Leu Glu Ser Met Arg Lys 
            980                 985                 990         


Lys Thr Gly Leu Arg Ile Asp Ile  
        995                 1000 


<210>  2420
<211>  1116
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2420

Met Glu Asn Thr Ile Glu Ile Gln Lys Gln Ser Ile Arg Thr Leu Asn 
1               5                   10                  15      


Asn Ala Pro Gln Tyr Phe Gly Leu Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn Tyr Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Glu Glu Glu Lys Ile Thr Ile Ser Phe Leu Gly Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Lys Gln Ser Tyr Ile Tyr Phe Asn Leu Ile 
65                  70                  75                  80  


Lys Tyr Met Pro Val Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Lys 
                85                  90                  95      


Asn Glu Ile Asp Lys Thr Lys Asn Asn Ser Gly Lys Asp Phe Asn Lys 
            100                 105                 110         


Leu Ser Asp Thr Leu Lys Val Ile Phe Lys Glu Leu Asn Glu Phe Arg 
        115                 120                 125             


Asn Asp Tyr Ser His Tyr Phe Ser Thr Glu Lys Gln Asp Lys Arg Lys 
    130                 135                 140                 


Leu Lys Ile Ser Ser Glu Leu Lys Asp Phe Leu Asn Ile Asn Phe Ser 
145                 150                 155                 160 


Arg Ala Leu Ser Tyr Thr Lys Asn Arg Leu Lys Asp Val Phe Ser Asp 
                165                 170                 175     


Asp Asp Phe Asn Ile Ala Ser Gln Thr Val Val Val Asn Asn Asp Asn 
            180                 185                 190         


Thr Ile Thr Gln Asp Gly Ile Val Phe Leu Ile Ser Met Phe Leu Asp 
        195                 200                 205             


Met Glu Asn Ala Phe Gln Phe Ile Asn Lys Ile Ile Gly Leu Lys Gly 
    210                 215                 220                 


Thr Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Val Leu Met Thr Phe 
225                 230                 235                 240 


Cys Val Lys Leu Pro His Asp Lys Phe Val Ser Glu Asn Pro Gln Gln 
                245                 250                 255     


Thr Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Leu 
            260                 265                 270         


Leu Tyr Asn Val Ile Thr Glu Glu Glu Lys Gln Ile Phe Lys Pro Gln 
        275                 280                 285             


Ile Gln Thr Glu Gln Ile Glu Asn Ile Ile Ser Asn Ser Val Pro Asp 
    290                 295                 300                 


Thr Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Ser Ile Thr Lys Lys Val 
305                 310                 315                 320 


Arg Tyr Glu Asn Arg Phe Ser Tyr Phe Ala Leu Lys Tyr Ile Asp Leu 
                325                 330                 335     


Lys Glu Leu Phe Lys Lys Trp Arg Phe Gln Ile Asp Leu Gly Lys Val 
            340                 345                 350         


Val Leu Asp Lys Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Val Arg 
        355                 360                 365             


Thr Val Thr Glu Asn Ala Lys Ala Phe Gly Arg Leu Gln Asp Phe Tyr 
    370                 375                 380                 


Asp Gln Glu Lys Ile Leu Asn Lys Ile Asn Ile Gly Glu Asn Lys Thr 
385                 390                 395                 400 


Arg Phe Tyr Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn 
                405                 410                 415     


Lys Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Ser Lys 
            420                 425                 430         


Asn Thr Thr His Lys Val Lys Phe Asn Leu Leu Gln Pro Leu Pro Glu 
        435                 440                 445             


Val Phe Leu Ser Ile His Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr 
    450                 455                 460                 


Leu Glu Gln Gly Lys Thr Glu Lys Leu Ile Asn Asn Phe Ile Lys Leu 
465                 470                 475                 480 


Ser Asn Ser Thr Ile Leu Asn Lys Lys Phe Ile Glu Thr Ile Lys Tyr 
                485                 490                 495     


Lys Leu Ser Asp Leu Asp Val Phe His Lys Arg Ser Met Gly Arg Lys 
            500                 505                 510         


Glu Ile Ser Ala Tyr Arg Lys Asp Ile Leu Lys Tyr Leu Ile Ala Arg 
        515                 520                 525             


Lys Glu Lys Leu Asn Gln Ile Leu Ser Glu His Asn Leu Ser Val Lys 
    530                 535                 540                 


Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp Leu Asn Ile Ala Asp Val 
545                 550                 555                 560 


Gln Glu Lys Thr Ala Ile Ser Asp Arg Ile Lys Leu Met Lys Arg Asp 
                565                 570                 575     


Cys Met Asp Arg Leu Lys Ala Ile Lys Lys Asn Asn Ala Pro Lys Ile 
            580                 585                 590         


Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile Val Asp Met Leu Ile 
        595                 600                 605             


Ser Glu Gly Lys Lys Lys Lys Ile Thr Ser Phe Tyr Tyr Asp Lys Met 
    610                 615                 620                 


Gln Glu Cys Leu Val Leu Phe Ala Asp Lys Glu Lys Lys Glu Leu Phe 
625                 630                 635                 640 


Ile Ser Ile Cys Ser Glu Leu Lys Leu Asn Asp Ala Asp Gly His Pro 
                645                 650                 655     


Phe Leu Lys Asn Ile Asn Leu Ser Asp Ile Arg Tyr Thr Ser Asp Leu 
            660                 665                 670         


Tyr Lys Ile Tyr Leu Gln Glu Lys Ala Asp Asn Arg Asn Gln Arg Asn 
        675                 680                 685             


Arg Thr Asp Thr Ser Trp Leu Ala Lys Asn Phe Tyr Thr Leu Lys Asn 
    690                 695                 700                 


Val Glu Val Phe Asp Lys Lys Gln Gln Arg Lys Ile Phe Lys Leu Gln 
705                 710                 715                 720 


Thr Ile Val Glu Leu Pro Gln Asp Lys Ser Lys Ile Pro Phe Thr Ile 
                725                 730                 735     


Arg Gln Leu Glu Lys Glu Lys Ser Ser Phe Asn Lys Trp Leu Glu Tyr 
            740                 745                 750         


Ile Thr Lys Gly Lys Glu Thr Thr Asp Lys Lys Lys Pro Val Asn Leu 
        755                 760                 765             


Pro Ala Asn Leu Phe Asp Asp Thr Leu Lys Lys Leu Leu Lys Thr Glu 
    770                 775                 780                 


Leu Ser Lys Asn Asn Ile Gln Tyr Asn Lys Glu Ala Asn Tyr Asn Gln 
785                 790                 795                 800 


Leu Phe Lys Ile Trp Trp Lys Glu Phe Arg Lys Asp Asn Thr Gln Asn 
                805                 810                 815     


Phe Tyr Thr Ala Glu Arg Glu Tyr Thr Phe Glu Glu Glu Lys Leu Asn 
            820                 825                 830         


Phe Lys Ile Asn Thr Gln Pro Lys Phe Glu Asn Tyr Tyr Thr Arg Phe 
        835                 840                 845             


Ala Glu Asn Val Phe Asn Lys Lys Gln Ala Leu Arg Asn Glu Glu Arg 
    850                 855                 860                 


Lys Thr Lys Arg Asn Leu Pro Pro Ile Gln Lys Ile His Val Ile Lys 
865                 870                 875                 880 


Lys Ile Arg Asn Lys Ile Gly Asn Thr Glu Lys Glu Ile Arg Met Leu 
                885                 890                 895     


Gln Glu Glu Asp Arg Leu Met Leu Leu Met Phe Glu Lys Leu Thr Lys 
            900                 905                 910         


Glu Asn Leu Asn Leu Lys Leu Glu Lys Val Asn Glu Leu Leu Asn Glu 
        915                 920                 925             


Arg Ile Glu Ile Lys Glu Lys Ile Pro Gly Lys Leu Ser Phe Asp Asp 
    930                 935                 940                 


Leu Gly Glu Lys Thr Ile Thr Arg Asn Ile Val Glu Thr Arg Lys Arg 
945                 950                 955                 960 


Lys Glu Tyr Ser Val Leu Gln Lys Tyr Ile Phe Asp Arg Arg Leu Pro 
                965                 970                 975     


Glu Leu Phe Glu Tyr Phe Asn Glu Thr Asp Ile Leu Ile Glu Lys Ile 
            980                 985                 990         


Lys Thr Glu Leu Asp Ala Tyr Asn  Lys Ala Lys Asp Ile  Val Phe Asp 
        995                 1000                 1005             


Leu Ile  Phe Lys Leu Glu Glu  Ala Ile Ile Lys Lys  Asp Glu Thr 
    1010                 1015                 1020             


Gly Ile  Lys Glu Leu Asn Lys  Asp Gln Asn Gly Asn  Ile Gln Thr 
    1025                 1030                 1035             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu His Trp Leu  Leu Lys Lys 
    1040                 1045                 1050             


Asn Met  Ile Thr Glu Lys Glu  Phe Thr Phe Ile Asn  Met Val Arg 
    1055                 1060                 1065             


Asn Thr  Phe Ser His Asn Arg  Phe Pro Gln Lys Lys  Thr Met Glu 
    1070                 1075                 1080             


Leu Phe  Ile Lys Lys Trp Asn  Asp Asn Asn Phe Ala  Tyr Gln Ile 
    1085                 1090                 1095             


Leu Glu  Thr Tyr Lys Gln Lys  Thr Asn Asn Ile Ile  Glu Lys Leu 
    1100                 1105                 1110             


Lys Asp  Met 
    1115     


<210>  2421
<211>  1129
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2421

Met Glu Thr Asn Gln Gln Thr His Glu Asn Arg Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Asn Asn His Ile Ala Thr Asp Phe Lys Gln Ala Thr 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ala Ala Phe Leu Cys Asn Lys Thr 
    50                  55                  60                  


Ile Lys Asn Leu Asn Trp Asn His Val His Thr Arg Ala Val Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ser Glu Ser Leu Pro Lys Asp Glu 
                85                  90                  95      


Arg Glu Asn Ser Asp Thr Glu Gly Lys Asp Phe Ala Ser Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Ser Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gln Asp Ser Arg Lys Leu Thr Val 
    130                 135                 140                 


Ser Pro Glu Leu Ala Asn Phe Leu Thr Val Asn Phe Gln Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Ala Arg Met Lys Asp Val Leu Thr Asp Ala Asp Tyr 
                165                 170                 175     


Ala Leu Val Glu Asn Leu Gln Met Val Ala Pro Asp Asn Lys Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ala Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Thr Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asn Leu Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Ser 
            260                 265                 270         


Val Ile Thr Asp Lys Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Asp Asp Glu Arg 
    290                 295                 300                 


Glu Arg Ile Leu Asp Glu Ile Asp Tyr Gln Asp Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg Tyr Ser Asn Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Asp Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Asn Tyr Thr Lys Gln Phe Ala Gly Glu 
        355                 360                 365             


Gln Ala Glu Arg Lys Val Leu Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asp Pro Glu Leu Ile Gln Gln Arg Ile Asp Lys Gln 
385                 390                 395                 400 


Gln His Thr Ala Gly Phe Asp Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Thr Lys Glu Asn Ile Ala Thr Leu Ile 
            420                 425                 430         


Ala Lys Ser Lys Ala Ser Ser Lys Val Glu His Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Gln Ala Glu Glu Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Ile Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Ser Gln Leu Pro Ala Asp Trp Asp Glu Phe Ser Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asp Ser Thr Leu Lys Tyr Leu 
        515                 520                 525             


Arg Gln Arg Lys Thr Thr Leu Asn Thr Ile Leu Ser Lys Ser Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Lys Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Thr Arg Leu Lys Ala Val Glu Lys His Lys Leu 
            580                 585                 590         


Asn Lys Ser Val Lys Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Glu Glu Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Ala Asn Ala Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Asn Asp Gly His Pro Phe Leu Gln Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Gln Ala Tyr Leu Ile 
        675                 680                 685             


Glu Lys Gly Asn Lys Met Val Pro Arg Leu Asn Pro Lys Thr Asn Lys 
    690                 695                 700                 


Thr Ser Lys Val Asp Glu Ser Trp Met Met Lys Gln Phe Tyr Val Lys 
705                 710                 715                 720 


Glu Trp Lys Glu Glu Ile Gly Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Ser Arg Ile Pro Phe Thr Ile Cys Gln Trp Asp Lys Lys 
            740                 745                 750         


Glu Ser His Asp Leu Asn Thr Trp Leu Gln His Val Thr Val Gly Lys 
        755                 760                 765             


Asn Lys Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe Asp 
    770                 775                 780                 


Glu Ala Leu Cys Asp Leu Leu Arg Glu Gln Leu Asp Thr Lys Ile Val 
785                 790                 795                 800 


Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Ile Trp Trp 
                805                 810                 815     


Lys Thr Arg Asn Asp Asp Thr Gln Gln Phe Tyr Gln Ser Glu Arg Glu 
            820                 825                 830         


Tyr Asp Ile Tyr Asn Glu Lys Val Arg Phe Lys Ile Asp Ser Ser Ala 
        835                 840                 845             


His Phe Ala Asp Tyr Tyr Lys Asn Ala Leu Ser Arg Ala Phe Thr Arg 
    850                 855                 860                 


Leu Lys Ala Glu Arg Glu Thr Ala Arg Gln Thr Asn Lys Lys Leu Pro 
865                 870                 875                 880 


Pro Leu Glu Tyr Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile Ala 
                885                 890                 895     


Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met Ala 
            900                 905                 910         


Val Leu Met Leu Glu Arg Leu Met Asp Asn Ser Pro Asn Leu Arg Leu 
        915                 920                 925             


Ser Lys Ile Glu Thr Leu Leu Asn Asp Thr Thr His Ile Ser Glu Lys 
    930                 935                 940                 


Ile Ser Ala Thr Leu Ser Phe Asp Ala Ser Gly Glu Arg Ile Ser Gly 
945                 950                 955                 960 


Lys Leu Lys Gln Thr Val Thr Lys Thr Leu Ile Ala Glu Arg Lys Gln 
                965                 970                 975     


Lys Asn Tyr Thr Glu Leu Arg Lys Tyr Arg Tyr Asp Arg Arg Leu Pro 
            980                 985                 990         


Glu Leu Phe Glu Tyr Val Gln Ala  Asp Glu Ile Pro Leu  Glu Trp Leu 
        995                 1000                 1005             


Leu Glu  Glu Leu Ser Ala Tyr  Asn Asn Ala Lys Gln  Gln Val Phe 
    1010                 1015                 1020             


Asp Thr  Val Phe Ala Leu Glu  Lys Lys Ile Val Gly  Thr Asp Pro 
    1025                 1030                 1035             


Asp Gly  Leu Lys Ser Leu Phe  Thr Asn Pro Lys Gly  Glu Pro Leu 
    1040                 1045                 1050             


Lys Gly  Asn Ile Gln His Lys  Pro Tyr Val Gln Trp  Leu Thr Asn 
    1055                 1060                 1065             


Lys Gly  Leu Ile Asn Lys Glu  Glu Lys Gln Phe Ile  Asn Met Val 
    1070                 1075                 1080             


Arg Lys  Cys Phe Ser His Asn  Gln Phe Pro Gln Arg  Lys Thr Met 
    1085                 1090                 1095             


Glu Leu  Leu Ile Pro Ala Trp  Asn Glu Lys Lys Leu  Ala Leu Gln 
    1100                 1105                 1110             


Ile Ala  Thr Val Tyr Asn Gln  Leu Ile Ala Asp Leu  Thr Asp Lys 
    1115                 1120                 1125             


Ile 
    


<210>  2422
<211>  1131
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2422

Met Glu Lys Thr Ile Glu Asn Gln Thr Gln Ser Lys Arg Thr Leu Asn 
1               5                   10                  15      


Asn Thr Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Asp Glu Glu Lys Ile Thr Thr Ser Phe Leu Val Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Arg Gln Ser Leu Val Tyr Ser Asn Leu Thr 
65                  70                  75                  80  


Arg Tyr Met His Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Asp 
                85                  90                  95      


Asp Glu Arg Asp Lys Ala Glu Asn Tyr Gly Lys Asp Phe Gly Asn Leu 
            100                 105                 110         


Thr Asp Thr Leu Lys Glu Ile Phe Lys Glu Leu Asn Glu Phe Arg Asn 
        115                 120                 125             


Asp Tyr Ser His Tyr Tyr Ser Thr Glu Lys Lys Asp Lys Arg Lys Thr 
    130                 135                 140                 


Ile Val Ser Asp Lys Leu Lys Asn Phe Leu Asn Ile Asn Tyr Thr Arg 
145                 150                 155                 160 


Ala Ile Lys Tyr Thr Lys Ser Arg Phe Ile Asn Val Phe Ser Asp Asn 
                165                 170                 175     


Asn Phe Cys Leu Ala Glu Glu Ala Lys His Val Glu Asn Asp Asn Thr 
            180                 185                 190         


Ile Thr Gln Asp Gly Ile Val Phe Phe Thr Ser Met Phe Leu Asp Arg 
        195                 200                 205             


Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile Ile Gly Leu Lys Gly Thr 
    210                 215                 220                 


Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Thr Leu Met Ala Phe Cys 
225                 230                 235                 240 


Val Asn Leu Pro His Asp Lys Phe Val Ser Glu Asn Ser Glu Gln Gln 
                245                 250                 255     


Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu 
            260                 265                 270         


Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln His Phe Leu Pro Lys Leu 
        275                 280                 285             


Asp Asp Glu Gln Ile Asp Asn Val Leu Glu Asn Ser Val Pro Tyr Thr 
    290                 295                 300                 


Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn Ile Thr Lys Lys Val Arg 
305                 310                 315                 320 


Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu Lys Phe Ile Asp Gln Lys 
                325                 330                 335     


Lys Leu Phe Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val 
            340                 345                 350         


Leu Asp Glu Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Lys Arg Thr 
        355                 360                 365             


Val Thr Glu Asn Thr Lys Ala Phe Gly Met Leu Gln Asp Leu Asn Asp 
    370                 375                 380                 


Glu Glu Asn Val Leu Asn Lys Ile Asn Thr Gly Glu Ser Lys Ala Lys 
385                 390                 395                 400 


Phe Asp Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Thr Lys Asn 
            420                 425                 430         


Thr Asp Asn Lys Ile Lys Ser Asn Leu Leu Gln Pro Leu Pro Glu Ala 
        435                 440                 445             


Phe Leu Ser Ile Asn Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
    450                 455                 460                 


Glu Gln Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn 
465                 470                 475                 480 


Asn Ser Lys Ile Leu Asn Lys Glu Phe Ile Lys Ala Ile Lys Leu Lys 
                485                 490                 495     


Leu Asn Asp Leu Asp Val Phe Tyr Lys Arg Ser Gln Gly Arg Lys Gln 
            500                 505                 510         


Lys His Ala Tyr Leu Thr Lys Asp Lys Lys Tyr Asp Asn Glu Lys Ile 
        515                 520                 525             


Asn Glu Leu Lys Asn Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu 
    530                 535                 540                 


Tyr Asn Leu Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp 
545                 550                 555                 560 


Leu Asn Ile Ala Asp Val Gln Ala Lys Asn Ala Ile Ser Asp Arg Ile 
                565                 570                 575     


Lys Leu Met Lys Arg Asp Cys Ile Asn Arg Leu Lys Ser Met Lys Lys 
            580                 585                 590         


Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp 
        595                 600                 605             


Ile Val Asp Met Ile Ile Asp Glu Glu Lys Lys Lys Lys Ile Thr Ser 
    610                 615                 620                 


Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Lys 
625                 630                 635                 640 


Glu Lys Lys Glu Leu Phe Ile Leu Ile Cys Asn Asn Glu Leu Lys Leu 
                645                 650                 655     


Asn Asp Asp Asp Gly His Pro Phe Phe Lys Asn Ile Asn Phe Ser Asn 
            660                 665                 670         


Tyr Lys Tyr Thr Ser Glu Ile Tyr Gln Lys Tyr Leu Glu Glu Lys Gly 
        675                 680                 685             


His Lys Met Val Lys Glu Tyr Asn Pro Arg Lys Glu Asn Tyr Val Glu 
    690                 695                 700                 


Lys Asp Lys Ser Trp Leu Glu Ile Asn Phe Tyr Lys Lys Glu Trp Asn 
705                 710                 715                 720 


Glu Asn Ala Lys Lys Asp Leu Thr Val Val Lys Leu Pro Asp Asp Lys 
                725                 730                 735     


Ser Lys Ile Pro Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser 
            740                 745                 750         


Phe Glu Asn Trp Phe Lys Tyr Val Thr Asn Gly Lys Glu Thr Thr Asp 
        755                 760                 765             


Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp Glu Thr Leu 
    770                 775                 780                 


Lys Glu Leu Leu Lys Lys Glu Leu Ser Lys Asn Asn Ile Glu Phe Lys 
785                 790                 795                 800 


Glu Glu Asp Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Asp Lys Cys 
                805                 810                 815     


Arg Asn Asp Lys Thr Gln Lys Phe Tyr Ser Ala Glu Arg Glu Tyr Thr 
            820                 825                 830         


Phe Glu Glu Glu Lys Leu Asn Phe His Ile Asn Thr Lys Ser Lys Phe 
        835                 840                 845             


Glu Glu Tyr Ile Asn Pro Glu Phe Ala Glu Lys Val Phe Arg Leu Lys 
    850                 855                 860                 


Asn Gln Asn Arg Glu Lys Asp Asn Ile Ser Gly Arg Arg Leu Pro Pro 
865                 870                 875                 880 


Leu Lys Met Lys Glu Val Thr Lys Asn Met Val Lys Arg Ile Gly Asn 
                885                 890                 895     


Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Leu Met Leu 
            900                 905                 910         


Leu Met Phe Glu Lys Leu Val Asp Asn Asn Leu Lys Leu Lys Leu Glu 
        915                 920                 925             


Asn Val Asp Lys Leu Leu Asn Glu Ser Ile Glu Ile Asn Gln Ser Ile 
    930                 935                 940                 


Ser Gly Lys Leu Ser Phe Asp Asp Ser Gly Asp Asn Glu Asn Lys Lys 
945                 950                 955                 960 


Asp Arg Ala Ile Ile Cys Arg Asn Ile Thr Glu Thr Arg Lys Arg Lys 
                965                 970                 975     


Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Glu Glu Glu  Asn Ile Pro Ile Glu  Lys Ile Lys 
        995                 1000                 1005             


Ile Glu  Leu Asp Thr Tyr Ser  Lys Ala Lys Asp Val  Val Phe Asp 
    1010                 1015                 1020             


Leu Ile  Phe Asp Leu Glu Arg  Ala Ile Ile Asn Lys  Asp Glu Asn 
    1025                 1030                 1035             


Arg Ile  Lys Glu Leu Asn Lys  Asp Lys Asn Gly Val  Ile Gln Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Phe Trp Leu  Leu Glu Lys 
    1055                 1060                 1065             


Asn Leu  Ile Thr Glu Gln Glu  Phe Thr Phe Met Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Thr  Phe Ser His Asn Gln  Phe Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Leu Phe  Ile Lys Asn Trp Asn  Glu Asn Glu Phe Ala  Lys Gln Ile 
    1100                 1105                 1110             


Leu Asn  Val Tyr Asn Gln Lys  Asn Asn Asn Leu Ile  Lys Ser Ile 
    1115                 1120                 1125             


Lys Asp  Ile 
    1130     


<210>  2423
<211>  1116
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2423

Met Glu Asn Thr Ile Glu Ile Gln Lys Gln Ser Ile Arg Thr Leu Asn 
1               5                   10                  15      


Asn Ala Pro Gln Tyr Phe Gly Leu Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn Tyr Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Glu Glu Glu Lys Ile Thr Ile Ser Phe Leu Gly Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Lys Gln Ser Tyr Ile Tyr Phe Asn Leu Ile 
65                  70                  75                  80  


Lys Tyr Met Pro Val Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Lys 
                85                  90                  95      


Asn Glu Ile Asp Lys Thr Lys Asn Asn Ser Gly Lys Asp Phe Asn Lys 
            100                 105                 110         


Leu Ser Asp Thr Leu Lys Val Ile Phe Lys Glu Leu Asn Glu Phe Arg 
        115                 120                 125             


Asn Asp Tyr Ser His Tyr Phe Ser Thr Glu Lys Gln Asp Lys Arg Lys 
    130                 135                 140                 


Leu Lys Ile Ser Ser Glu Leu Lys Asp Phe Leu Asn Ile Asn Phe Ser 
145                 150                 155                 160 


Arg Ala Leu Ser Tyr Thr Lys Asn Arg Leu Lys Asp Val Phe Ser Asp 
                165                 170                 175     


Asp Asp Phe Asn Ile Ala Ser Gln Thr Val Val Val Asn Asn Asp Asn 
            180                 185                 190         


Thr Ile Thr Gln Asp Gly Ile Val Phe Leu Ile Ser Met Phe Leu Asp 
        195                 200                 205             


Met Glu Asn Ala Phe Gln Phe Ile Asn Lys Ile Ile Gly Leu Lys Gly 
    210                 215                 220                 


Thr Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Val Leu Met Thr Phe 
225                 230                 235                 240 


Cys Val Lys Leu Pro His Asp Lys Phe Val Ser Glu Asn Pro Gln Gln 
                245                 250                 255     


Thr Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Leu 
            260                 265                 270         


Leu Tyr Asn Val Ile Thr Glu Glu Glu Lys Gln Ile Phe Lys Pro Gln 
        275                 280                 285             


Ile Gln Thr Glu Gln Ile Glu Asn Ile Ile Ser Asn Ser Val Pro Asp 
    290                 295                 300                 


Thr Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Ser Ile Thr Lys Lys Val 
305                 310                 315                 320 


Arg Tyr Glu Asn Arg Phe Ser Tyr Phe Ala Leu Lys Tyr Ile Asp Leu 
                325                 330                 335     


Lys Glu Leu Phe Lys Lys Trp Arg Phe Gln Ile Asp Leu Gly Lys Val 
            340                 345                 350         


Val Leu Asp Lys Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Val Arg 
        355                 360                 365             


Thr Val Thr Glu Asn Ala Lys Ala Phe Gly Arg Leu Gln Asp Phe Tyr 
    370                 375                 380                 


Asp Gln Glu Lys Ile Leu Asn Lys Ile Asn Ile Gly Glu Asn Lys Thr 
385                 390                 395                 400 


Arg Phe Tyr Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn 
                405                 410                 415     


Lys Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Ser Lys 
            420                 425                 430         


Asn Thr Thr His Lys Val Lys Phe Asn Leu Leu Gln Pro Leu Pro Glu 
        435                 440                 445             


Val Phe Leu Ser Ile His Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr 
    450                 455                 460                 


Leu Glu Gln Gly Lys Thr Glu Lys Leu Ile Asn Asn Phe Ile Lys Leu 
465                 470                 475                 480 


Ser Asn Ser Thr Ile Leu Asn Lys Lys Phe Ile Glu Thr Ile Lys Tyr 
                485                 490                 495     


Lys Leu Ser Asp Leu Asp Val Phe His Lys Arg Ser Met Gly Arg Lys 
            500                 505                 510         


Glu Ile Ser Ala Tyr Arg Lys Asp Ile Leu Lys Tyr Leu Ile Ala Arg 
        515                 520                 525             


Lys Glu Lys Leu Asn Gln Ile Leu Ser Glu His Asn Leu Ser Val Lys 
    530                 535                 540                 


Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp Leu Asn Ile Ala Asp Val 
545                 550                 555                 560 


Gln Glu Lys Thr Ala Ile Ser Asp Arg Ile Lys Leu Met Lys Arg Asp 
                565                 570                 575     


Cys Met Asp Arg Leu Lys Ala Ile Lys Lys Asn Asn Ala Pro Lys Ile 
            580                 585                 590         


Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile Val Asp Met Leu Ile 
        595                 600                 605             


Ser Glu Gly Lys Lys Lys Lys Ile Thr Ser Phe Tyr Tyr Asp Lys Met 
    610                 615                 620                 


Gln Glu Cys Leu Val Leu Phe Ala Asp Lys Glu Lys Lys Glu Leu Phe 
625                 630                 635                 640 


Ile Ser Ile Cys Ser Glu Leu Lys Leu Asn Asp Ala Asp Gly His Pro 
                645                 650                 655     


Phe Leu Lys Asn Ile Asn Leu Ser Asp Ile Arg Tyr Thr Ser Asp Leu 
            660                 665                 670         


Tyr Lys Ile Tyr Leu Gln Glu Lys Ala Asp Asn Arg Asn Gln Arg Asn 
        675                 680                 685             


Arg Thr Asp Thr Ser Trp Leu Ala Lys Asn Phe Tyr Thr Leu Lys Asn 
    690                 695                 700                 


Val Glu Val Phe Asp Lys Lys Gln Gln Arg Lys Ile Phe Lys Leu Gln 
705                 710                 715                 720 


Thr Ile Val Glu Leu Pro Gln Asp Lys Ser Lys Ile Pro Phe Thr Ile 
                725                 730                 735     


Arg Gln Leu Glu Lys Glu Lys Ser Ser Phe Asn Lys Trp Leu Glu Tyr 
            740                 745                 750         


Ile Thr Lys Gly Lys Glu Thr Thr Asp Lys Lys Lys Pro Val Asn Leu 
        755                 760                 765             


Pro Ala Asn Leu Phe Asp Asp Thr Leu Lys Lys Leu Leu Lys Thr Glu 
    770                 775                 780                 


Leu Ser Lys Asn Asn Ile Gln Tyr Asn Lys Glu Ala Asn Tyr Asn Gln 
785                 790                 795                 800 


Leu Phe Lys Ile Trp Trp Lys Glu Phe Arg Lys Asp Asn Thr Gln Asn 
                805                 810                 815     


Phe Tyr Thr Ala Glu Arg Glu Tyr Thr Phe Glu Glu Glu Lys Leu Asn 
            820                 825                 830         


Phe Lys Ile Asn Thr Gln Pro Lys Phe Glu Asn Tyr Tyr Thr Arg Phe 
        835                 840                 845             


Ala Glu Asn Val Phe Asn Lys Lys Gln Ala Leu Arg Asn Glu Glu Arg 
    850                 855                 860                 


Lys Thr Lys Arg Asn Leu Pro Pro Ile Gln Lys Ile His Val Ile Lys 
865                 870                 875                 880 


Lys Ile Arg Asn Lys Ile Gly Asn Thr Glu Lys Glu Ile Arg Met Leu 
                885                 890                 895     


Gln Glu Glu Asp Arg Leu Met Leu Leu Met Phe Glu Lys Leu Thr Lys 
            900                 905                 910         


Glu Asn Leu Asn Leu Lys Leu Glu Lys Val Asn Glu Leu Leu Asn Glu 
        915                 920                 925             


Arg Ile Glu Ile Lys Glu Lys Ile Pro Gly Lys Leu Ser Phe Asp Asp 
    930                 935                 940                 


Leu Gly Glu Lys Thr Ile Thr Arg Asn Ile Val Glu Thr Arg Lys Arg 
945                 950                 955                 960 


Lys Glu Tyr Ser Val Leu Gln Lys Tyr Ile Phe Asp Arg Arg Leu Pro 
                965                 970                 975     


Glu Leu Phe Glu Tyr Phe Asn Glu Thr Asp Ile Leu Ile Glu Lys Ile 
            980                 985                 990         


Lys Thr Glu Leu Asp Ala Tyr Asn  Lys Ala Lys Asp Ile  Val Phe Asp 
        995                 1000                 1005             


Leu Ile  Phe Lys Leu Glu Glu  Ala Ile Ile Lys Lys  Asp Glu Thr 
    1010                 1015                 1020             


Gly Ile  Lys Glu Leu Asn Lys  Asp Gln Asn Gly Asn  Ile Gln Thr 
    1025                 1030                 1035             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu His Trp Leu  Leu Lys Lys 
    1040                 1045                 1050             


Asn Met  Ile Thr Glu Lys Glu  Phe Thr Phe Ile Asn  Met Val Arg 
    1055                 1060                 1065             


Asn Thr  Phe Ser His Asn Arg  Phe Pro Gln Lys Lys  Thr Met Glu 
    1070                 1075                 1080             


Leu Phe  Ile Lys Lys Trp Asn  Asp Asn Asn Phe Ala  Tyr Gln Ile 
    1085                 1090                 1095             


Leu Glu  Thr Tyr Lys Gln Lys  Thr Asn Asn Ile Ile  Glu Lys Leu 
    1100                 1105                 1110             


Lys Asp  Met 
    1115     


<210>  2424
<211>  1129
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2424

Met Lys Glu Glu Glu Glu Lys Gly Lys Thr Pro Val Val Ser Thr Tyr 
1               5                   10                  15      


Asn Lys Asp Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg 
            20                  25                  30          


His Asn Val Tyr Ile Thr Ile Asn His Ile Asn Lys Leu Leu Glu Ile 
        35                  40                  45              


Arg Glu Ile Asp Asn Asp Glu Lys Val Leu Asp Ile Lys Ala Leu Trp 
    50                  55                  60                  


Gln Lys Val Asn Lys Asp Leu Asn Gln Lys Ala Arg Leu Arg Glu Leu 
65                  70                  75                  80  


Met Thr Lys His Phe Pro Phe Leu Glu Thr Ala Ile Tyr Thr Lys Asn 
                85                  90                  95      


Lys Glu Asp Lys Lys Glu Val Lys Glu Glu Lys Gln Ala Lys Ala Gln 
            100                 105                 110         


Ser Phe Asp Ser Leu Asn His Cys Leu Phe Leu Phe Leu Glu Lys Leu 
        115                 120                 125             


Gln Glu Ala Arg Asn Tyr Tyr Ser His Tyr Lys Tyr Ser Glu Ser Ser 
    130                 135                 140                 


Lys Glu Pro Met Leu Glu Lys Glu Leu Leu Lys Lys Met Tyr Asn Ile 
145                 150                 155                 160 


Phe Asp Asn Asn Ile Gln Leu Val Ile Lys Asp Tyr Gln His Asn Lys 
                165                 170                 175     


Asp Ile Asn Pro Asp Glu Asp Phe Lys His Leu Asp Arg Thr Glu Glu 
            180                 185                 190         


Asp Phe Asn Tyr Tyr Phe Ala Arg Asn Lys Lys Gly Asn Ile Thr Ala 
        195                 200                 205             


Ser Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala 
    210                 215                 220                 


Ile Trp Met Gln Gln Lys Leu Thr Gly Phe Lys Asp Asn Arg Glu Asn 
225                 230                 235                 240 


Lys Lys Lys Met Thr His Glu Val Phe Cys Arg Ser Arg Met Leu Leu 
                245                 250                 255     


Pro Lys Leu Arg Leu Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu 
            260                 265                 270         


Asp Met Leu Asn Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg 
        275                 280                 285             


Leu Lys Gly Glu Asp Arg Lys Lys Phe Glu Val Pro Phe Asp Ser Thr 
    290                 295                 300                 


Asp Glu Asp Tyr Asp Ala Glu Gln Asp Pro Phe Lys Asn Thr Leu Ile 
305                 310                 315                 320 


Arg His Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe Asp Tyr 
                325                 330                 335     


Asn Glu Ile Phe Lys Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr 
            340                 345                 350         


His Phe Ser Ile Tyr Lys Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg 
        355                 360                 365             


His Leu Thr His Lys Leu Tyr Gly Phe Glu Arg Ile Gln Glu Phe Thr 
    370                 375                 380                 


Lys Gln His Arg Pro Asp Asp Trp Lys Ala Ile Val Lys Asp Phe Asp 
385                 390                 395                 400 


Thr Tyr Glu Thr Ser Glu Glu Pro Tyr Ile Ser Glu Thr Thr Pro His 
                405                 410                 415     


Tyr His Leu Glu Asn Gln Lys Ile Gly Ile Arg Phe Arg Asn Gly Asn 
            420                 425                 430         


Asn Asp Ile Trp Pro Ser Leu Glu Thr Asn Gly Glu Asn Asn Glu Lys 
        435                 440                 445             


Ser Lys Tyr Lys Leu Asp Lys Pro Tyr Gln Ala Glu Ala Phe Leu Ser 
    450                 455                 460                 


Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Lys Lys 
465                 470                 475                 480 


Glu Glu Pro Asn Asn Asp Lys Lys Asn Ala Ser Arg Val Glu Gly Phe 
                485                 490                 495     


Ile Lys Arg Glu Ile Arg Asp Ile Phe Lys Leu Tyr Asp Ala Phe Ala 
            500                 505                 510         


Asn Asp Glu Ile Asn Asn Ile Asp Asp Leu Lys Lys Tyr Cys Lys Asp 
        515                 520                 525             


Lys His Ile Glu Ile Arg His Leu Pro Lys Gln Met Ile Ala Ile Leu 
    530                 535                 540                 


Glu Ser Lys Pro Lys Asp Met Ala Lys Glu Ala Lys Arg Lys Gln Lys 
545                 550                 555                 560 


Glu Met Val Lys Asp Thr Lys Lys Leu Leu Ala Thr Leu Glu Lys Gln 
                565                 570                 575     


Thr Gln Lys Glu Lys Glu Asp Asp Gly Arg Asn Val Lys Leu Leu Lys 
            580                 585                 590         


Ser Gly Glu Ile Ala Arg Trp Leu Val Asn Asp Met Met Arg Phe Gln 
        595                 600                 605             


Pro Val Gln Lys Asp Asn Glu Gly Lys Pro Leu Asn Asn Ser Lys Ala 
    610                 615                 620                 


Asn Ser Thr Glu Tyr Gln Met Leu Gln Arg Ser Leu Ala Leu Tyr Asn 
625                 630                 635                 640 


Lys Glu Glu Asn Pro Thr Arg Tyr Phe Arg Gln Val Asn Leu Ile Glu 
                645                 650                 655     


Ser Ser Asn Pro His Pro Phe Leu Lys Trp Thr Lys Trp Glu Glu Cys 
            660                 665                 670         


Asn Asn Ile Leu Thr Phe Tyr Tyr Thr Tyr Leu Thr Lys Lys Ile Glu 
        675                 680                 685             


Phe Leu Asn Lys Leu Lys Pro Glu Asp Trp Lys Lys Asn Gln Tyr Phe 
    690                 695                 700                 


Leu Lys Leu Lys Glu Pro Lys Thr Asn Arg Lys Thr Leu Val Gln Gly 
705                 710                 715                 720 


Trp Lys Asn Gly Phe Asn Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile 
                725                 730                 735     


Arg Glu Trp Phe Glu Arg His Gln Asn Asp Ser Glu Glu Tyr Lys Lys 
            740                 745                 750         


Val Glu Lys Leu Asn Lys Ala Gly Leu Val Thr Lys Val Ile Pro Leu 
        755                 760                 765             


Phe Phe Lys Lys Glu Asp Ser Lys Asp Lys Glu Glu Tyr Leu Lys Lys 
    770                 775                 780                 


Asp Thr Gln Lys Glu Ile Asn Asp Cys Val Gln Pro Phe Tyr Asn Phe 
785                 790                 795                 800 


Pro Tyr Asn Val Gly Asn Ile His Lys Ser Asp Glu Lys Asp Phe Leu 
                805                 810                 815     


His Arg Glu Glu Arg Ile Glu Leu Trp Asp Lys Lys Lys Asp Lys Phe 
            820                 825                 830         


Lys Gly Tyr Lys Glu Lys Ile Lys Ser Lys Lys Leu Thr Glu Lys Glu 
        835                 840                 845             


Lys Glu Glu Phe Arg Ser Tyr Leu Glu Phe Gln Ser Trp Asn Asn Phe 
    850                 855                 860                 


Glu Arg Glu Leu Arg Leu Val Arg Asn Gln Asp Ile Val Thr Trp Leu 
865                 870                 875                 880 


Leu Cys Lys Glu Leu Ile Asp Lys Leu Lys Ile Asp Glu Leu Asn Ile 
                885                 890                 895     


Glu Glu Leu Lys Lys Leu Arg Leu Asn Asn Ile Asp Thr Asp Thr Ala 
            900                 905                 910         


Lys Lys Glu Lys Asn Asn Ile Leu Asn Arg Val Met Pro Met Glu Leu 
        915                 920                 925             


Pro Val Met Val Tyr Glu Val Asn Lys Ala Gly Asn Ile Ile Lys Asn 
    930                 935                 940                 


Lys Pro Leu His Thr Ile Tyr Ile Lys Glu Ala Lys Thr Lys Leu Leu 
945                 950                 955                 960 


Lys Gln Gly Asn Phe Lys Ala Leu Val Lys Asp Arg Arg Leu Asn Gly 
                965                 970                 975     


Leu Phe Ser Phe Val Lys Thr Asn Ser Glu Ala Glu Ser Lys Arg Asn 
            980                 985                 990         


Pro Ile Ser Lys Leu Leu Val Glu  His Glu Leu Gly Glu  Tyr Gln Glu 
        995                 1000                 1005             


Ala Arg  Ile Glu Ile Ile Lys  Asp Met Leu Ala Leu  Glu Glu Thr 
    1010                 1015                 1020             


Leu Ile  Asn Lys Tyr Lys Asp  Leu Pro Thr Asn Lys  Phe Ser Asp 
    1025                 1030                 1035             


Met Leu  Asn Ser Trp Leu Glu  Gly Lys Asp Glu Ala  Asp Lys Ala 
    1040                 1045                 1050             


Arg Phe  Gln Asn Asp Val Asp  Phe Leu Ile Ala Val  Arg Asn Ala 
    1055                 1060                 1065             


Phe Ser  His Asn Gln Tyr Pro  Met His Asn Lys Ile  Glu Phe Ala 
    1070                 1075                 1080             


Asn Ile  Lys Pro Phe Ser Leu  Tyr Thr Met Asn Asn  Ser Glu Glu 
    1085                 1090                 1095             


Lys Gly  Leu Gly Ile Ala Asn  Gln Leu Lys Asp Lys  Thr Lys Glu 
    1100                 1105                 1110             


Thr Lys  Asp Lys Ile Ile Glu  Ile Glu Lys Pro Ile  Glu Thr Lys 
    1115                 1120                 1125             


Glu 
    


<210>  2425
<211>  1126
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2425

Met Glu Thr Leu Leu Thr Pro Thr Glu Asn Lys Tyr Arg Thr Ile Asn 
1               5                   10                  15      


Asp Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Ser Met Ala Arg Leu Asn 
            20                  25                  30          


Val Phe Asn Ile Ser Asn His Ile Ala Lys Glu Phe Gly Gln Ser Leu 
        35                  40                  45              


Leu Glu Glu Glu Gly His Ile Lys Asn Ser Phe Leu Cys Asp Lys Asn 
    50                  55                  60                  


Asn Lys Lys Val Asn Trp Asn His Val His Ala Lys Ala Arg Arg Phe 
65                  70                  75                  80  


Leu Ser Ile Leu Lys Val Phe Asp Ala Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Leu Lys Ile Ile Glu Trp Glu Gly Lys Asp Phe Ser Leu Met Gly Asp 
            100                 105                 110         


Thr Leu Lys Ile Val Phe Arg Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Phe Tyr Ser Thr Glu Lys Gly Thr Ser Arg Lys Ile Lys Val 
    130                 135                 140                 


Ser Glu Glu Leu Ala Glu Phe Leu Lys Thr Asn Phe Arg Arg Ala Ile 
145                 150                 155                 160 


Glu Tyr Thr Lys Glu Arg Phe Lys Gly Gly Leu Ile Glu Glu Asp Phe 
                165                 170                 175     


Asn Leu Val Ala Ser Arg Lys Val Val Arg Asp Asp Leu Ala Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ala Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Thr Gly Leu Lys Gly Thr Gln Asn 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro His Asp Arg Phe Gln Ser Asp Asn Thr Arg Gln Ala Phe Ser 
                245                 250                 255     


Leu Asp Leu Ile Asn Glu Leu Asn Arg Cys Pro Lys Val Leu Tyr Asn 
            260                 265                 270         


Val Ile Thr Glu Glu Gly Lys Gln Leu Phe Arg Pro Gln Leu Glu Asp 
        275                 280                 285             


Leu Glu Ile Lys Asn Leu Ile Lys Asn Ser Thr Asn Asn Glu Glu Glu 
    290                 295                 300                 


Ile Asp Asn Tyr Asp Glu Tyr Ile Glu Ala Leu Thr Lys Arg Ile Arg 
305                 310                 315                 320 


His Thr Asn Arg Phe Ser Asp Phe Ala Leu Gln Phe Ile Asp Glu Thr 
                325                 330                 335     


Asp Val Phe Lys Lys Phe Arg Phe Gln Ile Asp Leu Gly Lys Leu Leu 
            340                 345                 350         


Val Asp Glu Tyr Asp Lys Ser Phe Asn Gly Glu Glu Val Glu Arg Lys 
        355                 360                 365             


Ile Ile Val Asn Ala Lys Ala Phe Arg Lys Leu Asn Ser Tyr Gly Thr 
    370                 375                 380                 


Glu Asp Glu Thr Leu Lys Leu Ile Glu Asn Gly Gln Gly Ser Lys Arg 
385                 390                 395                 400 


Phe Glu Gln Phe Ala Pro His Tyr Asn Thr Glu Asn Asn Lys Ile Gly 
                405                 410                 415     


Leu Ser Gly Lys Glu Leu Ile Ala Lys Leu Arg Pro Asn Ser Lys Gly 
            420                 425                 430         


Glu Ala Gly Lys Lys Leu His Gln Pro Leu Pro Glu Ala Phe Leu Ser 
        435                 440                 445             


Leu Lys Glu Leu Pro Lys Ile Ile Leu Leu Asn Tyr Leu Leu Pro Asp 
    450                 455                 460                 


Glu Pro Glu Lys Leu Ile Asn Asp Phe Ile Leu Val Asn Asn Ser Lys 
465                 470                 475                 480 


Leu Met Asn Met Ser Phe Ile Lys Glu Val Lys Ser Leu Leu Pro Lys 
                485                 490                 495     


Glu Trp Asn Glu Phe Lys Lys Arg Ser Asp Thr Lys Lys Gln Arg Ala 
            500                 505                 510         


Tyr Asn Glu Lys Ala Leu Ala Tyr Leu Leu His Arg Lys Gln Ile Leu 
        515                 520                 525             


Asn Gln Val Leu Ala Ala Tyr Gln Leu Asn Asp Lys Gln Ile Pro Arg 
    530                 535                 540                 


Arg Ile Leu Asp Tyr Trp Leu Asn Ile Val Asp Val Val Glu Gly Arg 
545                 550                 555                 560 


Ser Val Ser Asp Arg Ile Lys Met Met Lys Arg Asp Cys Met Ser Arg 
                565                 570                 575     


Leu Lys Ala Met Ala Lys Phe Lys Glu Asp Arg Asn Arg Asn Lys Ile 
            580                 585                 590         


Pro Lys Ile Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile Val Asp 
        595                 600                 605             


Met Val Val Gly Glu Glu Lys Lys Gln Lys Ile Thr Ser Phe Tyr Tyr 
    610                 615                 620                 


Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Pro Glu Lys Lys 
625                 630                 635                 640 


Gln Leu Phe Ile His Thr Val Ile Asn Glu Leu Lys Leu Asn Glu Gln 
                645                 650                 655     


Gly Gly His Pro Phe Leu His Lys Leu Asn Leu Gln Gln Ile Lys Asn 
            660                 665                 670         


Thr Ser Gly Phe Tyr Glu Ile Tyr Leu Gln Glu Lys Gly Gln Lys Met 
        675                 680                 685             


Val Ser Glu Lys Asn Phe Arg Thr Gly Arg Thr Ile Glu Thr Asp Lys 
    690                 695                 700                 


Ser Trp Met Ala Leu Thr Phe Tyr Lys Lys Glu Trp Asp Glu Lys Val 
705                 710                 715                 720 


Gly Lys Gln Leu Thr Val Val Arg Leu Pro Glu Asn Lys Ser Asn Ile 
                725                 730                 735     


Pro Phe Ser Leu Arg Leu Leu Glu Glu Lys Thr Val Tyr Thr Leu Glu 
            740                 745                 750         


Gln Trp Leu His Asn Val Thr Lys Gly Lys Lys Gln Asn Asp Thr Arg 
        755                 760                 765             


Gln Pro Val Asn Leu Pro Thr Asn Leu Phe Asp Glu Arg Leu Thr Val 
    770                 775                 780                 


Leu Leu Arg Gly Glu Leu Asp Lys Lys Gln Ile Ser Tyr Ala Pro Asn 
785                 790                 795                 800 


Ala Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Lys Ser Arg Asn Asp 
                805                 810                 815     


Ser Val Gln Ser Phe Tyr Lys Ala Glu Arg Glu Tyr Glu Ile Phe Gly 
            820                 825                 830         


Glu Lys Val Asn Phe Met Pro Asp Ser Lys Glu Arg Phe Ala Asp Tyr 
        835                 840                 845             


Tyr Gln His Ala Leu Thr Ala Ala Trp Gln Lys Lys Arg Lys Glu Arg 
    850                 855                 860                 


Ile Gln Gln Gln Lys Gln Asp Arg Arg Leu Pro Asp Ile Ser Phe Asp 
865                 870                 875                 880 


Gln Val Glu Lys Thr Phe Lys Gln Thr Ile Ala Glu Thr Glu Lys Glu 
                885                 890                 895     


Ile Arg Ile Val Gln Glu Glu Asp Arg Met Met Leu Leu Met Leu Glu 
            900                 905                 910         


Thr Leu Met Glu Asn Gly Lys Asp Leu Lys Leu Lys Leu Ser Gly Ile 
        915                 920                 925             


Asp Thr Leu Leu Asn Ala Thr Thr Glu Val Lys Gln Leu Val Ser Gly 
    930                 935                 940                 


Lys Leu Ser Phe Asn Gly Ser Gly Glu Leu Ile Lys Gly Lys Thr Asn 
945                 950                 955                 960 


Pro Glu Ile Ser Lys Thr Ile Thr Val Ala Arg Lys Arg Lys Asp Tyr 
                965                 970                 975     


Ser Met Leu Arg Lys Phe Val Phe Asp Arg Arg Leu Pro Glu Leu Phe 
            980                 985                 990         


Glu Tyr Phe Ala Glu Glu Glu Ile  Pro Ile Glu Val Leu  Lys Asp Glu 
        995                 1000                 1005             


Leu Asp  Ala Tyr Asn Lys Ala  Lys His Glu Val Phe  Asp Thr Val 
    1010                 1015                 1020             


Phe Glu  Leu Glu Glu Lys Ile  Ile Thr Leu Asp Ala  Asp Gly Ile 
    1025                 1030                 1035             


Arg Gln  Leu Phe Ile Asp Asp  Ala Gly Gln Pro Val  Thr Gly Asn 
    1040                 1045                 1050             


Ile Gln  His Lys Pro Tyr Val  Ile Trp Leu Lys Asn  Asn Gly Thr 
    1055                 1060                 1065             


Ile Asp  Asp Asn Thr Leu Thr  Phe Leu Asn Met Val  Arg Asn Cys 
    1070                 1075                 1080             


Phe Ser  His Asn Gln Tyr Pro  Gln Lys Lys Thr Met  Glu Leu Leu 
    1085                 1090                 1095             


Ile Gly  Gln Trp Glu Pro Asn  Arg Phe Ala Leu Thr  Ile Ala Gln 
    1100                 1105                 1110             


Thr Tyr  Lys Arg Lys Ile Asn  Ser Ile Met Lys His  Leu 
    1115                 1120                 1125     


<210>  2426
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2426

Leu Gln Lys Gln Asp Lys Leu Phe Val Asp Arg Lys Lys Asn Ala Ile 
1               5                   10                  15      


Phe Ala Phe Pro Lys Tyr Ile Thr Ile Met Glu Asn Lys Glu Lys Thr 
            20                  25                  30          


Glu Pro Ile Tyr Tyr Glu Leu Thr Asp Lys His Phe Trp Ala Ala Phe 
        35                  40                  45              


Leu Asn Leu Ala Arg His Asn Val Tyr Thr Thr Val Asn His Ile Asn 
    50                  55                  60                  


Lys Leu Leu Glu Ile Ala Glu Leu Lys Asn Asp Glu Asp Val Leu Asn 
65                  70                  75                  80  


Ile Lys Asp Ser Trp Asn Lys Gln Ala Glu Lys Leu Asp Lys Lys Val 
                85                  90                  95      


Arg Leu Arg Asn Leu Leu Met Arg His Phe Pro Phe Leu Glu Ala Ala 
            100                 105                 110         


Ala Tyr Glu Lys Thr Thr Ser Lys Asp Ser Asn Ser Lys Glu Gln Lys 
        115                 120                 125             


Glu Lys Glu Gln Ala Glu Ala Leu Ser Leu Asp Asn Leu Lys Asn Val 
    130                 135                 140                 


Leu Phe Ile Phe Leu Glu Lys Leu Gln Ser Leu Arg Asn Tyr Tyr Ser 
145                 150                 155                 160 


His Tyr Lys Tyr Ser Glu Glu Ala Gln Lys Pro Thr Phe Glu Asn Asp 
                165                 170                 175     


Leu Leu Lys Asn Met Tyr Lys Ile Phe Asp Thr Asn Val Arg Leu Val 
            180                 185                 190         


Lys Arg Asp Tyr Met His His Glu Asn Val Asp Met Gln Arg Asp Phe 
        195                 200                 205             


Ser His Leu Asn Arg Lys Lys Gln Glu Gly Gln Thr Arg Lys Ile Ile 
    210                 215                 220                 


Ala Asn Pro Asn Phe Arg Tyr His Phe Ala Asp Glu Lys Gly Asp Met 
225                 230                 235                 240 


Thr Ile Ala Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Asp Lys Lys 
                245                 250                 255     


Asp Ala Ile Trp Met Gln Lys Lys Leu Lys Gly Phe Lys Asp Gly Arg 
            260                 265                 270         


Asn Leu Arg Glu Gln Met Thr Asn Glu Val Phe Cys Arg Ser Arg Ile 
        275                 280                 285             


Ser Leu Pro Lys Leu Lys Leu Glu Asn Val Gln Thr Lys Asp Trp Met 
    290                 295                 300                 


Gln Leu Asp Met Leu Asn Glu Leu Val Arg Cys Pro Lys Ser Leu Tyr 
305                 310                 315                 320 


Glu Arg Leu Arg Glu Lys Asp Arg Glu Ser Phe Lys Val Pro Phe Asp 
                325                 330                 335     


Ile Phe Ser Asp Asp Tyr Asp Ala Glu Glu Glu Pro Phe Lys Asn Thr 
            340                 345                 350         


Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe 
        355                 360                 365             


Asp Leu Asn Glu Ile Phe Glu Gln Leu Arg Phe Gln Ile Asp Leu Gly 
    370                 375                 380                 


Thr Tyr His Phe Ser Ile Tyr Asn Lys Arg Ile Gly Asp Glu Asp Glu 
385                 390                 395                 400 


Val Arg His Leu Thr His His Leu Tyr Gly Phe Ala Arg Ile Gln Asp 
                405                 410                 415     


Phe Ala Pro Gln Asn Gln Pro Glu Glu Trp Arg Lys Leu Val Lys Asp 
            420                 425                 430         


Leu Asp His Phe Glu Thr Ser Gln Glu Pro Tyr Ile Ser Lys Thr Ala 
        435                 440                 445             


Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Lys Phe Cys Ser 
    450                 455                 460                 


Thr His Asn Asn Leu Phe Pro Ser Leu Lys Arg Glu Lys Thr Cys Asn 
465                 470                 475                 480 


Gly Arg Ser Lys Phe Asn Leu Gly Thr Gln Phe Thr Ala Glu Ala Phe 
                485                 490                 495     


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu 
            500                 505                 510         


Thr Lys Asp Tyr Ser Arg Lys Glu Ser Ala Asp Lys Val Glu Gly Ile 
        515                 520                 525             


Ile Arg Lys Glu Ile Ser Asn Ile Tyr Ala Ile Tyr Asp Ala Phe Ala 
    530                 535                 540                 


Asn Asn Glu Ile Asn Ser Ile Ala Asp Leu Thr Cys Arg Leu Gln Lys 
545                 550                 555                 560 


Thr Asn Ile Leu Gln Gly His Leu Pro Lys Gln Met Ile Ser Ile Leu 
                565                 570                 575     


Glu Gly Arg Leu Lys Asp Met Glu Lys Glu Ala Glu Arg Lys Ile Gly 
            580                 585                 590         


Glu Met Ile Asp Asp Thr Gln Arg Arg Leu Asp Leu Leu Cys Lys Gln 
        595                 600                 605             


Thr Asn Gln Lys Ile Arg Ile Gly Lys Arg Asn Ala Gly Leu Leu Lys 
    610                 615                 620                 


Ser Gly Lys Ile Ala Asp Trp Leu Val Ser Asp Met Met Arg Phe Gln 
625                 630                 635                 640 


Pro Val Gln Lys Asp Thr Asn Asn Ala Pro Ile Asn Asn Ser Lys Ala 
                645                 650                 655     


Asn Ser Thr Glu Tyr Arg Met Leu Gln His Ala Leu Ala Leu Phe Gly 
            660                 665                 670         


Ser Glu Ser Ser Arg Leu Lys Ala Tyr Phe Arg Gln Met Asn Leu Val 
        675                 680                 685             


Gly Asn Ala Asn Pro His Pro Phe Leu Ala Glu Thr Gln Trp Glu His 
    690                 695                 700                 


Gln Thr Asn Ile Leu Ser Phe Tyr Arg Asn Tyr Leu Glu Ala Arg Lys 
705                 710                 715                 720 


Lys Tyr Leu Lys Gly Leu Lys Pro Gln Asn Trp Lys Gln Tyr Gln His 
                725                 730                 735     


Phe Leu Ile Leu Lys Val Gln Lys Thr Asn Arg Asn Thr Leu Val Thr 
            740                 745                 750         


Gly Trp Lys Asn Ser Phe Asn Leu Pro Arg Gly Ile Phe Thr Gln Pro 
        755                 760                 765             


Ile Arg Glu Trp Phe Glu Lys His Asn Asn Ser Lys Arg Ile Tyr Asp 
    770                 775                 780                 


Gln Ile Leu Ser Phe Asp Arg Val Gly Phe Val Ala Lys Ala Ile Pro 
785                 790                 795                 800 


Leu Tyr Phe Ala Glu Glu Tyr Lys Asp Asn Val Gln Pro Phe Tyr Asp 
                805                 810                 815     


Tyr Pro Phe Asn Ile Gly Asn Lys Leu Lys Pro Gln Lys Gly Gln Phe 
            820                 825                 830         


Leu Asp Lys Lys Glu Arg Val Glu Leu Trp Gln Lys Asn Lys Glu Leu 
        835                 840                 845             


Phe Lys Asn Tyr Pro Ser Glu Lys Lys Lys Thr Asp Leu Ala Tyr Leu 
    850                 855                 860                 


Asp Phe Leu Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys 
865                 870                 875                 880 


Asn Gln Asp Ile Val Thr Trp Leu Met Phe Lys Glu Leu Phe Lys Thr 
                885                 890                 895     


Thr Thr Val Glu Gly Leu Lys Ile Gly Glu Ile His Leu Arg Asp Ile 
            900                 905                 910         


Asp Thr Asn Thr Ala Asn Glu Glu Ser Asn Asn Ile Leu Asn Arg Ile 
        915                 920                 925             


Met Pro Met Lys Leu Pro Val Lys Thr Tyr Glu Thr Asp Asn Lys Gly 
    930                 935                 940                 


Asn Ile Leu Lys Glu Arg Pro Leu Ala Thr Phe Tyr Ile Glu Glu Thr 
945                 950                 955                 960 


Glu Thr Lys Val Leu Lys Gln Gly Asn Phe Lys Val Leu Ala Lys Asp 
                965                 970                 975     


Arg Arg Leu Asn Gly Leu Leu Ser Phe Ala Glu Thr Thr Asp Ile Asp 
            980                 985                 990         


Leu Glu Lys Asn Pro Ile Thr Lys  Leu Ser Val Asp His  Glu Leu Ile 
        995                 1000                 1005             


Lys Tyr  Gln Thr Thr Arg Ile  Ser Ile Phe Glu Met  Thr Leu Gly 
    1010                 1015                 1020             


Leu Glu  Lys Lys Leu Ile Asp  Lys Tyr Ser Thr Leu  Pro Thr Asp 
    1025                 1030                 1035             


Ser Phe  Arg Asn Met Leu Glu  Arg Trp Leu Gln Cys  Lys Ala Asn 
    1040                 1045                 1050             


Arg Pro  Glu Leu Lys Asn Tyr  Val Asn Ser Leu Ile  Ala Val Arg 
    1055                 1060                 1065             


Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met Tyr Asp  Ala Thr Leu 
    1070                 1075                 1080             


Phe Ala  Glu Val Lys Lys Phe  Thr Leu Phe Pro Ser  Val Asp Thr 
    1085                 1090                 1095             


Lys Lys  Ile Glu Leu Asn Ile  Ala Pro Gln Leu Leu  Glu Ile Val 
    1100                 1105                 1110             


Gly Lys  Ala Ile Lys Glu Ile  Glu Lys Ser Glu Asn  Lys Asn 
    1115                 1120                 1125         


<210>  2427
<211>  1113
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2427

Met Glu Ser Leu Ile Gln Gln Glu Glu Asn Lys Ala Arg Asn Leu Ile 
1               5                   10                  15      


Asp Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg His Asn 
            20                  25                  30          


Ile Phe Ser Ile Asn Asn His Leu Ala Ser Tyr Phe Gly Thr Ser Gly 
        35                  40                  45              


Leu Ser Asn Glu Glu Gln Ile Pro Asp Ser Phe Leu Leu Ser Ala Asp 
    50                  55                  60                  


Lys Arg Arg Asn Gln Glu Thr Lys Glu Leu Ile Lys Glu Asn Leu Leu 
65                  70                  75                  80  


Phe Glu Arg Thr Leu Arg Phe Met Pro Ile Phe Arg Ile Phe Asp Thr 
                85                  90                  95      


Glu Arg Leu Pro Lys Glu Val Arg Leu Asn Thr Glu Asn Met Glu Lys 
            100                 105                 110         


Asp Phe Asp Glu Met Arg Lys Cys Leu Lys Gln Val Phe Ser Glu Leu 
        115                 120                 125             


Asn Ile Phe Arg Asn Asp Tyr Thr His Tyr Phe Ser Thr Asn Thr Glu 
    130                 135                 140                 


Thr Thr Arg Lys Leu Gln Val Thr Pro Glu Leu Glu Glu Phe Leu Ser 
145                 150                 155                 160 


Arg Ser Phe Lys Leu Ala Ile Ala Phe Thr Lys Gln Arg Met Arg Asp 
                165                 170                 175     


Val Leu Lys Glu Glu Asp Tyr Ser Leu Val Glu Lys Lys Val Met Val 
            180                 185                 190         


Leu Pro Glu Glu Arg Val Ile Thr Thr Glu Gly Ile Val Phe Leu Ala 
        195                 200                 205             


Cys Met Phe Leu Glu Arg Glu Tyr Ala Phe Gln Phe Ile Gly Lys Val 
    210                 215                 220                 


Val Gly Leu Lys Gly Thr His Arg Asn Glu Phe Ile Ala Thr Arg Glu 
225                 230                 235                 240 


Val Leu Met Ala Tyr Cys Val Lys Leu Pro His Asp Lys Phe Ile Ser 
                245                 250                 255     


Glu Asp Ser Lys Gln Ala Leu Ile Leu Asp Ile Ala Asn Glu Leu Asn 
            260                 265                 270         


Lys Cys Pro Leu Thr Leu Tyr Asp Val Ile Thr Glu Asp Gly Arg Lys 
        275                 280                 285             


Gln Phe Arg Pro Glu Leu Thr Asp Asp Ala Lys Lys Ser Val Ile Glu 
    290                 295                 300                 


Asn Cys Ile Asn Glu Asp Leu Glu Val Asp Tyr Asp Glu Tyr Ile Gln 
305                 310                 315                 320 


Ile Leu Thr Lys Lys Val Arg Tyr Lys Asn Arg Phe Pro Tyr Phe Ala 
                325                 330                 335     


Phe Gln Tyr Ile Glu Glu Thr Lys Leu Leu Asp Asn Phe Arg Phe Ser 
            340                 345                 350         


Ile Asp Leu Gly Gln Phe Val Leu Ala Glu Tyr Glu Lys Arg Met Ala 
        355                 360                 365             


Gly Glu Pro Thr Ser Arg Ile Val Val Glu Asn Val Lys Ala Phe Lys 
    370                 375                 380                 


Tyr Leu Lys Glu Val Thr Asp Glu Asp Val Val Leu Gly Leu Met Lys 
385                 390                 395                 400 


Ser Asn Pro Pro Ser Asn Arg Phe Leu Gln Phe Ser Pro His Tyr Asn 
                405                 410                 415     


Ser Asp Asn Asn Lys Ile Gly Ile Ser Ser Lys Pro Gln Thr Ser Val 
            420                 425                 430         


Val Lys Ser Lys Gly Lys Ile Asp Ser Lys Ile Glu Tyr Lys Ile Lys 
        435                 440                 445             


Gln Pro Leu Pro Arg Ala Phe Val Ser Ile His Glu Leu Pro Lys Ile 
    450                 455                 460                 


Ile Leu Leu Asp Tyr Leu Ser Lys Gly Ser Val Val Lys Ile Ile Asn 
465                 470                 475                 480 


Ser Phe Ile Arg Thr Asn Lys Ser Ile Ile Leu Asp Val Asp Lys Ile 
                485                 490                 495     


Lys Glu Ile Lys Glu Lys Leu Pro Asn Asn Glu Val Trp Phe Pro Phe 
            500                 505                 510         


Arg Arg Met Thr Asp Ser Lys Lys His Ser Ala Tyr Ser Glu Lys Gln 
        515                 520                 525             


Lys Ala Glu Ile Leu Arg Arg Lys Lys Leu Leu Asn Glu Ile Leu Ser 
    530                 535                 540                 


Ser Tyr Ser Leu Asn Ile Lys Gln Ile Pro Ser Arg Ile Ile Asp Tyr 
545                 550                 555                 560 


Trp Leu Asn Ile Ile Asp Val Arg Lys Glu Arg Ser Phe Ser Asp Arg 
                565                 570                 575     


Ile Lys Leu Met Lys Arg Asp Cys Ala Asp Arg Tyr Lys Ala Val Lys 
            580                 585                 590         


Arg Asn Glu Lys Asp Lys Thr Val Ala Ile Pro Lys Ile Gly Glu Met 
        595                 600                 605             


Ala Thr Phe Leu Ala Lys Asp Ile Val Ala Met Ile Val Asp Glu Asp 
    610                 615                 620                 


Lys Lys Ser Lys Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys 
625                 630                 635                 640 


Leu Ala Leu Tyr Ala Asn Ile Glu Lys Lys Asn Leu Phe Ile His Leu 
                645                 650                 655     


Val Thr Asn Glu Leu Lys Leu Asn Glu Lys Gly Gly His Pro Phe Leu 
            660                 665                 670         


Lys Arg Ile Asn Leu Asn Ser Ile Thr Arg Thr Lys Glu Leu Tyr Glu 
        675                 680                 685             


Ile Tyr Leu Ser Glu Lys Ala Tyr Lys Leu Asn Ser Lys Glu Asn Asp 
    690                 695                 700                 


Glu Ser Trp Met Ser Met Thr Phe Tyr His Leu Glu Trp Asn Glu Lys 
705                 710                 715                 720 


Ala Lys Lys Lys Met Thr Lys Val Val Tyr Pro Val Asn Asp Glu Gln 
                725                 730                 735     


Ile Pro Tyr Thr Ile Lys Gln Trp Asn Lys Pro Gln Gln Pro Leu Phe 
            740                 745                 750         


Asp Arg Phe Thr Asn Glu Gln Gly Lys Ser Ser Asp Trp Val Arg Leu 
        755                 760                 765             


Lys Pro Leu Asp Leu Pro Thr Asn Leu Phe Asp Glu Glu Ile Cys Val 
    770                 775                 780                 


Gln Leu Arg Ser Arg Leu Gln Glu Ala Lys Ile Pro Phe Asp Asn Ile 
785                 790                 795                 800 


Ser Asn Tyr Ser Glu Leu Leu Lys Leu Trp Trp Lys Ser Arg Asp Asp 
                805                 810                 815     


Ser Thr Gln Pro Phe Tyr Leu Leu Glu Arg Gln Tyr Asn Ile Tyr Asp 
            820                 825                 830         


Glu Ser Val Arg Phe Thr Leu Asn Ser Lys Asn Lys Phe Lys Asp Tyr 
        835                 840                 845             


Tyr Gln Ala Ala Leu Lys Lys Val Phe Asn Gln Lys Lys Ala Glu Arg 
    850                 855                 860                 


Glu Ala Lys Arg Arg Phe Asn Lys Arg Leu Pro Asp Ile Gln Phe Lys 
865                 870                 875                 880 


Asp Val Glu Arg Val Phe Lys His Ala Ile Ala Glu Thr Glu Lys Gln 
                885                 890                 895     


Ile Arg Ile Ile Gln Glu Glu Asp Arg Ile Met Leu Leu Met Leu Glu 
            900                 905                 910         


Lys Leu Met Asp Asp Gln Gln Leu Lys Leu Gly Lys Ala Glu Thr Leu 
        915                 920                 925             


Leu Ser Ser Thr Val Pro Val Lys Gln Lys Ile Gly Asp Lys Thr Asn 
    930                 935                 940                 


Ser Ser Arg Val Ile Val Ala Gln Arg Lys Gln Lys His Tyr Thr Val 
945                 950                 955                 960 


Leu Arg Lys Tyr Gln Tyr Asp Arg Arg Leu Pro Glu Leu Phe Lys Tyr 
                965                 970                 975     


Thr Thr Glu Lys Glu Glu Leu Lys Leu Glu Trp Leu Glu Asp Glu Leu 
            980                 985                 990         


Lys Ala Tyr Asn Lys Gly Lys Leu  Lys Val Phe Asp Leu  Val Phe Ser 
        995                 1000                 1005             


Leu Glu  Lys Arg Ile Ile Glu  Val Ala Lys Gln Asp  Ile Ile Ala 
    1010                 1015                 1020             


Leu Leu  Asp Lys Ser Gly Ser  Asn Asp Ser Lys Phe  Asn Val Asp 
    1025                 1030                 1035             


His Lys  Pro Tyr Ile Lys Trp  Leu Glu Asn Met Glu  Leu Ile Asn 
    1040                 1045                 1050             


Ser Lys  Glu Ala Gly Phe Met  Lys Lys Ile Arg Asn  Ser Phe Ser 
    1055                 1060                 1065             


His Asn  Gln Phe Pro Glu Cys  Gln Thr Val Glu Leu  Met Ile Ser 
    1070                 1075                 1080             


Leu Lys  Ser Asp Ile Pro Ile  Ala Thr Gln Ile Val  Asn Glu Tyr 
    1085                 1090                 1095             


Glu Arg  Leu Ile Leu Arg Ile  Ser Ser Gln Ile Glu  Lys Met Lys 
    1100                 1105                 1110             


<210>  2428
<211>  1363
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2428

Met Pro Asn Val Gln Phe Glu Leu Val Pro Val Asn Tyr Ser Ile Pro 
1               5                   10                  15      


Tyr Asp Glu Gln Pro Glu Cys Lys Arg His Val Ile Gly Ala Tyr Ala 
            20                  25                  30          


Asn Leu Ala Arg His Asn Met Ala Leu Thr Ile Asn Thr Ile Met Gln 
        35                  40                  45              


Ala Ile Glu Met Glu Thr Phe Asp Glu Asn Ser Ile Gly Asp Ala Phe 
    50                  55                  60                  


Ser Lys Ser His Arg Leu Glu Ile Ala Gln Leu Asp Asn Val Lys Lys 
65                  70                  75                  80  


Leu Thr Leu Gln Lys Arg Leu Tyr Arg His Phe Pro Phe Phe Lys Arg 
                85                  90                  95      


Leu Lys Leu Glu Asp Glu Lys Lys Lys Ser Val Gln Leu Lys Thr Leu 
            100                 105                 110         


Leu Glu Val Met Ser Asp Phe Thr Asp Tyr Met Ala Phe Leu Arg Asn 
        115                 120                 125             


Thr Tyr Thr His Tyr Asn Pro Tyr Ile Thr Pro Glu Lys Glu Ile Ile 
    130                 135                 140                 


Tyr Lys Glu Leu Ser Glu Arg Val Gly Lys Leu Leu Asp Gln Leu Phe 
145                 150                 155                 160 


Glu Asn Ser Cys Arg Val Tyr Lys Lys Gly Glu Lys Ile Pro His Glu 
                165                 170                 175     


Asn Asn Glu Val Phe Ala Thr Gln Arg Lys Leu Thr Pro His Glu Lys 
            180                 185                 190         


Asp Ile Leu Met Asn Arg Asp Glu Glu Phe Ala Thr Ile Leu Leu Gln 
        195                 200                 205             


Val Gln Asn Glu Ile Lys Lys Arg Lys Glu Glu Tyr Val Glu Ala Val 
    210                 215                 220                 


Lys Lys Gln Gln Glu Asp Leu Lys Lys Gly Ile Lys Pro Thr Lys Glu 
225                 230                 235                 240 


Leu Lys Pro Val Ser Glu Thr Glu Val Lys Ile Gly Lys Asp Thr Phe 
                245                 250                 255     


Ile Ile Gly Ser Asp Gly Lys Ser Ile Arg Lys Asn Trp Asn Gln Tyr 
            260                 265                 270         


Asp Arg Asn Pro Gln Tyr Tyr Ala Arg Met Cys Asp Ala Asn Asn Gly 
        275                 280                 285             


Ile Ser Asp Ala Gly Ile Ile Tyr Phe Leu Cys Leu Phe Leu Asp Lys 
    290                 295                 300                 


Gln Val Ser Ile Asp Phe Met Asp Glu Val Gly Phe Thr Glu Gln Cys 
305                 310                 315                 320 


Asp Phe Ser Glu Gly Asn Ile Val Tyr Leu Lys Glu Leu Met Cys Met 
                325                 330                 335     


Asn Arg Ile Arg Met Val Lys Met Arg Leu Asp Ser Glu Met Asn Glu 
            340                 345                 350         


Thr Ala Leu Ala Leu Asp Met Met Ser Glu Leu Arg Lys Cys Pro Gln 
        355                 360                 365             


Pro Leu Tyr Glu Val Leu Asp Lys Phe Ala Arg Asp Glu Phe Lys Asp 
    370                 375                 380                 


Asp Ser Thr Val Lys Trp Glu Met Glu His Gln Gln Glu Ala Thr Leu 
385                 390                 395                 400 


Ala Asp Ser Gln Lys Asp Glu Glu Ser Leu Glu Arg Asp Ser Ala Pro 
                405                 410                 415     


Ile Lys Asn Thr Pro Arg Ser Thr Tyr Val Arg Trp Asp Asp Arg Phe 
            420                 425                 430         


Thr Glu Leu Ala Leu Gln Tyr Ile Asp Arg Gln Cys Val Phe Thr Asp 
        435                 440                 445             


Ile Arg Phe Gln Leu Arg Leu Gly Lys Tyr Arg Phe Ala Phe Tyr Asn 
    450                 455                 460                 


His Asn Thr Lys Glu Ser Ile Asp Gly Ile Glu Arg Leu Arg Ile Leu 
465                 470                 475                 480 


Gln Lys Glu Met His Gly Phe Gly Arg Ile His Glu Val Glu Lys Ile 
                485                 490                 495     


Val Lys Asp Lys Trp Lys Asn Tyr Phe Asp Lys Lys Asn Val Glu Asp 
            500                 505                 510         


Gly Leu Thr Lys Lys Ser Pro Asp Met Val Gly Gln Ala Pro Tyr Ile 
        515                 520                 525             


Thr Glu Gln Arg Pro Gln Tyr Asp Ile Asp Glu Lys Ser His Ser Ile 
    530                 535                 540                 


Gly Leu Arg Trp Glu Gly Trp Glu Asn Glu Asp Arg Lys Thr Ile Lys 
545                 550                 555                 560 


Asp Asn Asn Gly Lys Glu Lys Lys Glu Pro His Tyr Gly Asp Leu Asp 
                565                 570                 575     


Gln Lys Lys Ala Phe Val Pro Tyr Leu Pro Asn Leu Gln Ala Thr Lys 
            580                 585                 590         


Gly Asp Glu Arg Gln Lys Asn Thr Ala Glu Arg Leu Leu Ser Pro Gln 
        595                 600                 605             


Cys Met Leu Ser Gln Tyr Asp Leu Pro Ala Leu Leu Phe His Gln Tyr 
    610                 615                 620                 


Leu Leu Glu Lys Tyr Gly Lys Asp Lys Ser Gln Thr Glu Lys Ile Ile 
625                 630                 635                 640 


Lys Asp Tyr Tyr Lys Asn Leu Arg Asp Phe Phe Asn Asp Val Asn Asn 
                645                 650                 655     


Ser Val Lys Lys Pro Leu Asp Ala Tyr His Leu Cys Ser Ser Asp Ile 
            660                 665                 670         


Pro Glu Lys Ile Arg Lys Tyr Leu Asn Gly Thr Asn Thr Asp Asn Phe 
        675                 680                 685             


Glu Arg Leu Lys Asn Ala Ala Asn Arg Arg Leu Leu Glu Arg Leu Glu 
    690                 695                 700                 


Arg Ile Gln Arg Met Gln Gln Lys Phe Asn Glu Lys Lys Asp Arg Ile 
705                 710                 715                 720 


Gly Ser Lys Asp Asn Lys Phe Asp Lys Leu Arg Ala Thr Ile Lys Thr 
                725                 730                 735     


Gly Gln Leu Gly Gln Trp Leu Met Arg Asp Ile Met Asp Trp Ile Pro 
            740                 745                 750         


Gln Asn Ser Gln Ala Arg Lys Lys Leu Thr Gly Gln Asn Tyr Val Val 
        755                 760                 765             


Leu Gln Ser Cys Ile Thr Met Leu Gly Gln Ser Phe Asp Glu Asn Gly 
    770                 775                 780                 


Asn Ile Ile Asp Ile Thr Leu Ser Lys Leu Lys Lys Ile Met Gln Asp 
785                 790                 795                 800 


Ala Lys Ile Ile Ala Met Asp Asp Glu Glu Asn Asp Ala Phe Ile Phe 
                805                 810                 815     


His Pro Phe Leu Tyr Leu Val Phe Ser Gln Ser Tyr Ile Asn Ser Val 
            820                 825                 830         


Glu Ser Phe Tyr Glu Lys Tyr Leu Glu Lys Glu Leu Asn Trp Ile Asn 
        835                 840                 845             


Ile Met Ile Glu Asp Ile Asn Lys Ser Arg Glu Glu Asp Ala Thr Ile 
    850                 855                 860                 


Cys Arg Tyr Arg Leu Leu Pro Phe Leu His His Asn Arg Thr Arg Trp 
865                 870                 875                 880 


Gln Lys Ala Asp Asp Lys Thr Ile Lys Ala Leu Ala Ser Arg Tyr Leu 
                885                 890                 895     


Glu His Pro Ile Gln Leu Pro Asn Gly Leu Phe Thr Glu Lys Ile Arg 
            900                 905                 910         


Leu Leu Leu Ala Glu Ile Ala Lys Glu Asn Asn Tyr Gln Glu Leu Ser 
        915                 920                 925             


Ala Glu Leu Asp Lys Ala Glu Asn Ala Ala His Leu Ile Asn Leu Tyr 
    930                 935                 940                 


His Thr Leu Val Glu Lys Asp Asp Ser Gln Arg Phe Tyr His Asn Glu 
945                 950                 955                 960 


Pro Thr Gln Lys Gly Thr Ile Lys Ser Pro Asn Ala Tyr Gly His Leu 
                965                 970                 975     


Tyr Arg Leu Phe Lys Lys Ile Tyr Gly Glu Lys Asn Glu Thr Thr Asn 
            980                 985                 990         


His Lys Tyr Lys Phe Gly Ser Thr  Glu Ile Asn Ser Leu  Phe Thr Lys 
        995                 1000                 1005             


Lys Lys  Asp Val Phe Val Ser  Lys Tyr Ile Ile Ser  Ile Lys Thr 
    1010                 1015                 1020             


Ile Asp  Tyr Lys Ile Tyr Asp  Tyr Ile Ile Lys Glu  Met Lys Lys 
    1025                 1030                 1035             


Glu Lys  Asp Leu Lys Pro Val  Asp Ile His Leu Phe  Ile Leu Asp 
    1040                 1045                 1050             


Trp Lys  Arg Lys Asn Tyr Thr  Asp Glu Glu Tyr Asn  Lys Ile Thr 
    1055                 1060                 1065             


Thr Ser  Asn Glu Arg Glu Glu  Val Lys Asn Gln Leu  Pro Val Ile 
    1070                 1075                 1080             


Leu Lys  Lys Ile Lys Glu Asp  Glu Arg Lys Ile Ile  Leu Asp His 
    1085                 1090                 1095             


Tyr Lys  Lys Met Arg Arg Met  Val Thr Lys Val Gln  Asp Asn Glu 
    1100                 1105                 1110             


Arg Thr  Ile Arg Arg Phe Lys  Thr Gln Asp Val Leu  Leu Leu Tyr 
    1115                 1120                 1125             


Met Ala  Arg Asn Ile Leu Lys  Ala Lys Asn Asn Asn  Lys Val Asp 
    1130                 1135                 1140             


Phe Thr  Thr Asp Phe Leu Leu  Lys Asn Val Cys Gln  Gly Asp Asn 
    1145                 1150                 1155             


Leu Leu  Asp Lys Thr Ile Asp  Phe Glu Trp Ile Val  Asn Ile Glu 
    1160                 1165                 1170             


Asp Lys  Thr Asn Ser Asp Glu  Glu Pro Lys Leu Ile  Glu Lys Arg 
    1175                 1180                 1185             


Ile Lys  Gln Glu Lys Met Lys  Met Lys Asn Tyr Gly  Gln Phe Tyr 
    1190                 1195                 1200             


Lys Phe  Ala Ser Asp His Gln  Arg Leu Glu Ser Leu  Leu Ser Arg 
    1205                 1210                 1215             


Leu Pro  Glu Thr Ile Phe Gln  Arg Ala Glu Ile Glu  Asn Glu Phe 
    1220                 1225                 1230             


Ala Tyr  Tyr Asp Thr Asn Arg  Ser Glu Val Phe Arg  Gln Val Tyr 
    1235                 1240                 1245             


Ile Ile  Glu Ser Glu Ala Tyr  Lys Leu Gln Pro Glu  Leu Leu Asp 
    1250                 1255                 1260             


Asp Ala  Asn Ala Thr Glu Asp  Trp Phe Trp Tyr Ile  Asp Pro Arg 
    1265                 1270                 1275             


Ser Asn  Lys Cys Arg Ala Arg  Arg Asn Asn Phe Met  Asn Leu Leu 
    1280                 1285                 1290             


Glu Thr  Leu Ala Ala Gly Lys  Asp Gly Ile Leu Asp  Glu Val Glu 
    1295                 1300                 1305             


Lys Arg  Thr Leu Gln Ser Thr  Arg Asn Ala Phe Gly  His Asn Thr 
    1310                 1315                 1320             


Tyr Asp  Val Asp Met Ser Val  Ile Phe Glu Gly Lys  Glu Asp Lys 
    1325                 1330                 1335             


Lys Lys  Ile Pro Asp Ile Ala  Asn Gly Ile Lys Ser  Lys Ile Asp 
    1340                 1345                 1350             


Lys Gln  Thr Lys Asp Leu Ile  Glu Asn Leu 
    1355                 1360             


<210>  2429
<211>  1128
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2429

Met Glu Thr Gln Ile Ser Asn Ile Glu Asn Lys Tyr Arg Ile Leu Asn 
1               5                   10                  15      


Asp Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Val Phe Asn Ile Ser Asn His Ile Ala Lys Glu Phe Asn Leu Pro Leu 
        35                  40                  45              


Leu Pro Glu Glu Gly His Leu Lys Asn Ser Phe Leu Cys Gln Lys Glu 
    50                  55                  60                  


Asn Lys Lys Val Asn Trp Asn His Ile Phe Ser Lys Thr Asn Arg Phe 
65                  70                  75                  80  


Leu Ser Ile Leu Lys Val Phe Asp Val Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Lys Met Thr Asp Ser Glu Gly Lys Glu Phe Ala Leu Met Ser Asp 
            100                 105                 110         


Ser Leu Lys Ile Val Phe Gly Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Asn Gly Thr Ser Arg Lys Thr Thr Val 
    130                 135                 140                 


Ser Asp Glu Met Ser Leu Phe Leu Arg Thr Asn Phe Leu Arg Ala Ile 
145                 150                 155                 160 


Gln Tyr Thr Lys Glu Arg Phe Lys Gly Val Leu Asn Asp Glu Asp Tyr 
                165                 170                 175     


Gln Leu Val Ala Ser Lys Lys Val Leu Glu Ala Asp Asn Thr Ile Thr 
            180                 185                 190         


Val Glu Gly Leu Val Phe Leu Thr Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Thr Gly Leu Lys Gly Thr Gln Asn 
    210                 215                 220                 


Asn Ser Phe Ile Ser Thr Arg Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro His Asp Arg Phe Gln Ser Asp Asp Thr Arg Gln Ala Phe Ser 
                245                 250                 255     


Leu Asp Leu Ile Asn Glu Leu Thr Arg Cys Pro Lys Glu Leu Tyr Asn 
            260                 265                 270         


Ala Ile Thr Glu Glu Gly Lys Met Lys Phe Gln Pro Lys Leu Asp Glu 
        275                 280                 285             


Pro Gly Ile Lys Asn Leu Leu Asp Asn Ser Thr Asn Asn Lys Lys Lys 
    290                 295                 300                 


Ile Asp Ala Glu Asp Tyr Asp Glu Tyr Ile Glu Ser Leu Thr Lys Arg 
305                 310                 315                 320 


Ile Arg Tyr Asn Asn Arg Phe Ser Asp Phe Ala Leu Lys Tyr Ile Glu 
                325                 330                 335     


Glu Thr Asp Ile Leu Gly Asp Phe Arg Phe Gln Ile Asp Leu Gly Lys 
            340                 345                 350         


Leu Phe Val Asp Glu Tyr Asp Lys Phe Phe Asn Gly Glu Glu Val Pro 
        355                 360                 365             


Arg Arg Ile Ile Glu Asn Val Lys Ala Phe Gly Lys Leu Asn Asp Phe 
    370                 375                 380                 


Asn Asp Glu Ser Ile Leu Leu Ala Gln Ile Glu Asn Gly Tyr Pro Ser 
385                 390                 395                 400 


Lys Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Thr Glu Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Val Lys Val Asp Thr Ala Lys Leu Arg Ser Asn Ser 
            420                 425                 430         


Lys Gly Glu Pro Gly Lys Asn Leu Asn Gln Pro Leu Pro Glu Ala Phe 
        435                 440                 445             


Leu Ser Leu Asn Glu Leu Pro Lys Ile Ile Leu Leu Asp Tyr Leu Gln 
    450                 455                 460                 


Lys Gly Glu Pro Glu Gln Leu Ile Asn Asp Phe Ile Leu Ile Asn Asn 
465                 470                 475                 480 


Ser Lys Leu Met Lys Met Ser Phe Ile Glu Glu Ile Lys Asn Leu Leu 
                485                 490                 495     


Pro Lys Glu Trp Asn Glu Phe Arg Lys Arg Ala Asp Thr Arg Lys Gln 
            500                 505                 510         


Ala Ala Tyr Asn Asn Glu Thr Leu Ala Tyr Leu Leu Glu Arg Lys Gln 
        515                 520                 525             


Ile Leu Asn Gln Val Leu Val Ser Tyr Gln Leu Asn Asp Lys Gln Ile 
    530                 535                 540                 


Pro Gly Arg Ile Leu Asp Tyr Trp Leu Asn Ile Lys Glu Val Glu Glu 
545                 550                 555                 560 


Gly Arg Ala Val Ser Asp Arg Leu Lys Leu Met Lys Arg Asp Cys Met 
                565                 570                 575     


Ser Arg Leu Lys Ala Leu Glu Lys Phe Lys Ile Asp Arg Asn Arg Ser 
            580                 585                 590         


Lys Ile Pro Lys Thr Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile 
        595                 600                 605             


Val Asp Met Val Val Ser Glu Gly Ile Lys Lys Lys Ile Thr Ser Phe 
    610                 615                 620                 


Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Pro Glu 
625                 630                 635                 640 


Lys Lys Arg Leu Phe Ile His Ile Val Ile Arg Glu Leu Arg Leu Asn 
                645                 650                 655     


Gly Thr Gly Gly His Pro Phe Leu Phe Gln Leu Asn Phe Asp Lys Ile 
            660                 665                 670         


Asn Cys Thr Ser Asp Phe Tyr Ser Glu Tyr Leu Arg Glu Lys Gly His 
        675                 680                 685             


Lys Met Val Lys Glu Lys Asn Leu Lys Thr Gly Lys Ile Val Leu Thr 
    690                 695                 700                 


Asp His Ser Trp Met Ala Leu Thr Phe Tyr Lys Leu Glu Phe Asn Asp 
705                 710                 715                 720 


Lys Val Asp Lys Leu Met Thr Val Val Lys Leu Pro Leu Asn Lys Leu 
                725                 730                 735     


Asn Ile Pro Phe Thr Leu Arg Gln Leu Glu Gly Lys Thr Ile Asn Thr 
            740                 745                 750         


Leu Glu Gln Trp Leu Gln Asn Ile Thr Lys Gly Lys Asn Gln Asn Asp 
        755                 760                 765             


Gly Lys His Pro Val Asn Leu Pro Thr Asn Leu Phe Asp Glu Arg Leu 
    770                 775                 780                 


Thr Ala Cys Leu Gln Lys Glu Leu Asp Lys Lys Gln Ile Ile Tyr Pro 
785                 790                 795                 800 


Pro Tyr Ala Asn Trp Asn Glu Leu Phe Lys Thr Trp Trp Lys Ser Arg 
                805                 810                 815     


Asn Asp Ser Thr Gln Ser Phe Tyr Asn Ala Glu Arg Glu Tyr Ile Ile 
            820                 825                 830         


Phe Asp Glu Lys Val Asn Phe Tyr Pro Asn Arg Gln Glu Lys Phe Ala 
        835                 840                 845             


Asp Tyr Tyr His His Ala Val Lys Ala Ala Tyr Gln Lys Lys Arg Asn 
    850                 855                 860                 


Glu Arg Thr Leu Gln Gln Lys Asp Asp Lys His Leu Pro Asp Ile Leu 
865                 870                 875                 880 


Phe Ala Gln Val Glu Lys Thr Phe Lys Gln Thr Ile Ala Gly Thr Glu 
                885                 890                 895     


Lys Glu Ile Arg Met Val Gln Glu Glu Asp Arg Ile Met Leu Val Met 
            900                 905                 910         


Leu Glu Ser Leu Leu Glu Asp Gly Lys Lys Leu Gln Leu Lys Leu Ser 
        915                 920                 925             


Glu Ile Asn Thr Leu Leu Asn Ala Thr Thr Glu Ile Lys Gln Val Val 
    930                 935                 940                 


Thr Ala Lys Leu Ser Phe Asn Asp Ser Gly Glu Ile Ile Lys Asp Lys 
945                 950                 955                 960 


Thr Asn Pro Glu Ile Thr Lys Thr Ile Thr Ala Val Arg Lys Arg Lys 
                965                 970                 975     


Asp Tyr Ser Val Leu Arg Lys Phe Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Gly Tyr Phe Asp Gly Asp  Glu Ile Gln Phe Glu  Ser Leu Lys 
        995                 1000                 1005             


Ala Glu  Leu Asp Ala Tyr Asn  Lys Ala Lys Gln Glu  Val Leu Asp 
    1010                 1015                 1020             


Val Val  Phe Lys Leu Glu Lys  Lys Ile Ile Ala Lys  Asp Cys Asn 
    1025                 1030                 1035             


Gly Val  Gln Gln Leu Phe Ser  Asp Glu Thr Gly Asn  Leu Leu Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Thr Trp Leu  Lys Ser Lys 
    1055                 1060                 1065             


Gly Leu  Ile Gly Asp Ser Thr  Phe Thr Phe Leu Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Cys  Phe Ser His Asn Gln  Tyr Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Arg Phe  Ile Asp His Trp Glu  Thr Asn Arg Phe Ala  Leu Thr Ile 
    1100                 1105                 1110             


Ala Thr  Lys Tyr Asn His Glu  Ile Thr Arg Ile Met  Glu Lys Ile 
    1115                 1120                 1125             


<210>  2430
<211>  1141
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2430

Met Glu Asp Asp Lys Lys Thr Thr Glu Ser Thr Asn Met Leu Asp Asn 
1               5                   10                  15      


Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val Tyr 
            20                  25                  30          


Ile Thr Val Asn His Ile Asn Lys Val Leu Glu Leu Lys Asn Lys Lys 
        35                  40                  45              


Asp Gln Asp Ile Ile Ile Asp Asn Asp Gln Asp Ile Leu Ala Ile Lys 
    50                  55                  60                  


Thr His Trp Glu Lys Val Asn Gly Asp Leu Asn Lys Thr Glu Arg Leu 
65                  70                  75                  80  


Arg Glu Leu Met Thr Lys His Phe Pro Phe Leu Glu Thr Ala Ile Tyr 
                85                  90                  95      


Thr Lys Asn Lys Glu Asp Lys Glu Glu Val Lys Gln Glu Lys Gln Ala 
            100                 105                 110         


Lys Ala Gln Ser Phe Asp Ser Leu Lys His Cys Leu Phe Leu Phe Leu 
        115                 120                 125             


Glu Lys Leu Gln Glu Ala Arg Asn Tyr Tyr Ser His Tyr Lys Tyr Ser 
    130                 135                 140                 


Glu Ser Thr Lys Glu Pro Met Leu Glu Lys Glu Leu Leu Lys Lys Met 
145                 150                 155                 160 


Tyr Asn Ile Phe Asp Asp Asn Ile Gln Leu Val Ile Lys Asp Tyr Gln 
                165                 170                 175     


His Asn Lys Asp Ile Asn Pro Asp Glu Asp Phe Lys His Leu Asp Arg 
            180                 185                 190         


Thr Glu Glu Glu Phe Asn Tyr Tyr Phe Thr Arg Asn Lys Lys Gly Asn 
        195                 200                 205             


Ile Thr Ala Ser Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys 
    210                 215                 220                 


Lys Asp Ala Ile Trp Met Gln Gln Lys Leu Arg Gly Phe Lys Asp Asn 
225                 230                 235                 240 


Arg Glu Ser Lys Lys Lys Met Thr His Glu Val Phe Cys Arg Arg Arg 
                245                 250                 255     


Met Leu Leu Pro Lys Leu Arg Leu Glu Ser Thr Gln Thr Gln Asp Trp 
            260                 265                 270         


Ile Leu Leu Asp Met Leu Asn Glu Leu Ile Arg Cys Pro Lys Ser Leu 
        275                 280                 285             


Tyr Glu Arg Leu Gln Gly Glu Asp Arg Glu Lys Phe Lys Val Pro Phe 
    290                 295                 300                 


Asp Pro Ala Asp Glu Asp Tyr Asp Ala Glu Gln Glu Pro Phe Lys Asn 
305                 310                 315                 320 


Thr Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr 
                325                 330                 335     


Phe Asp Tyr Asn Glu Ile Phe Thr Asn Leu Arg Phe Gln Ile Asp Leu 
            340                 345                 350         


Gly Thr Tyr His Phe Ser Ile Tyr Lys Lys Leu Ile Gly Gly Gln Lys 
        355                 360                 365             


Glu Asp Arg His Leu Thr His Lys Leu Tyr Gly Phe Glu Arg Ile Gln 
    370                 375                 380                 


Glu Phe Ala Lys Gln Asn Arg Thr Asp Glu Trp Lys Ala Ile Val Lys 
385                 390                 395                 400 


Asp Leu Asp Thr Tyr Glu Thr Ser Asn Glu Arg Tyr Ile Ser Glu Thr 
                405                 410                 415     


Ile Pro His Tyr His Leu Glu Asn Gln Lys Ile Gly Ile Arg Phe Arg 
            420                 425                 430         


Asn Asp Asn Asp Glu Ile Trp Pro Ser Leu Lys Thr Asn Gly Glu Asn 
        435                 440                 445             


Asn Glu Lys Arg Lys Tyr Lys Leu Asp Lys Gln Tyr Gln Ala Glu Ala 
    450                 455                 460                 


Phe Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu 
465                 470                 475                 480 


Leu Lys Met Glu Asn Thr Asp Asn Gly Lys Glu Asn Asn Glu Val Gly 
                485                 490                 495     


Thr Lys Lys Lys Arg Asn Lys Asn Asn Glu Gln Glu Lys His Lys Ile 
            500                 505                 510         


Glu Glu Ile Ile Glu Asn Lys Ile Lys Asp Ile Tyr Ala Leu Tyr Asp 
        515                 520                 525             


Ala Phe Ala Asn Gly Glu Ile Asn Ser Glu Glu Glu Leu Lys Glu Tyr 
    530                 535                 540                 


Leu Lys Gly Lys Asp Ile Glu Ile Val His Leu Pro Lys Gln Met Ile 
545                 550                 555                 560 


Ala Ile Leu Glu Ser Lys Pro Lys Asp Met Val Lys Glu Ala Lys Arg 
                565                 570                 575     


Lys Gln Lys Glu Met Val Lys Asp Thr Lys Lys Leu Leu Ala Ala Leu 
            580                 585                 590         


Glu Lys Gln Thr Gln Gly Glu Ile Glu Asp Gly Gly Arg Asn Ile Arg 
        595                 600                 605             


Leu Leu Lys Ser Gly Glu Ile Ala Arg Trp Leu Val Asn Asp Met Met 
    610                 615                 620                 


Arg Phe Gln Pro Val Gln Lys Asp Asn Glu Gly Asn Pro Leu Asn Asn 
625                 630                 635                 640 


Ser Lys Ala Asn Ser Thr Glu Tyr Gln Met Leu Gln Arg Ser Leu Ala 
                645                 650                 655     


Leu Tyr Asn Lys Glu Glu Lys Pro Thr Arg Tyr Phe Arg Gln Val Asn 
            660                 665                 670         


Leu Ile Asn Ser Ser Asn Pro His Pro Phe Leu Lys Trp Thr Lys Trp 
        675                 680                 685             


Glu Glu Cys Asn Asn Ile Leu Ser Phe Tyr Arg Ser Tyr Leu Thr Lys 
    690                 695                 700                 


Lys Ile Glu Phe Leu Asn Lys Leu Lys Pro Glu Glu Trp Lys Lys Asn 
705                 710                 715                 720 


Gln Tyr Phe Leu Lys Leu Lys Glu Pro Lys Thr Asn Arg Glu Thr Leu 
                725                 730                 735     


Val Gln Gly Trp Lys Asn Gly Phe Asn Leu Pro Arg Gly Ile Phe Thr 
            740                 745                 750         


Glu Pro Ile Arg Glu Trp Phe Lys Arg His Gln Asn Asp Ser Lys Glu 
        755                 760                 765             


Tyr Glu Lys Val Glu Ala Leu Asp Arg Val Gly Leu Val Ala Lys Val 
    770                 775                 780                 


Ile Pro Leu Phe Phe Lys Glu Glu Tyr Phe Lys Glu Asp Ala Gln Lys 
785                 790                 795                 800 


Glu Ile Asn Asn Cys Val Gln Pro Phe Tyr Ser Phe Pro Tyr Asn Val 
                805                 810                 815     


Gly Asn Ile His Lys Pro Asp Glu Lys Asp Phe Leu Pro Ser Glu Glu 
            820                 825                 830         


Arg Lys Lys Arg Trp Gly Asp Lys Lys Tyr Lys Phe Lys Gly Tyr Lys 
        835                 840                 845             


Ala Lys Val Lys Ser Lys Lys Leu Thr Asp Lys Glu Lys Glu Glu Tyr 
    850                 855                 860                 


Arg Ser Tyr Leu Glu Phe Gln Ser Trp Asn Lys Phe Glu Arg Glu Leu 
865                 870                 875                 880 


Arg Leu Val Arg Asn Gln Asp Ile Val Thr Trp Leu Leu Cys Thr Glu 
                885                 890                 895     


Leu Ile Asp Lys Leu Lys Val Glu Gly Leu Asn Val Glu Glu Leu Gln 
            900                 905                 910         


Lys Leu Arg Leu Lys Asp Ile Asp Thr Asp Thr Ala Lys Gln Glu Lys 
        915                 920                 925             


Asn Asn Ile Leu Asn Arg Ile Met Pro Met Gln Leu Pro Val Thr Val 
    930                 935                 940                 


Tyr Glu Ile Asp Asp Ser His Asn Ile Val Lys Asp Lys Pro Leu His 
945                 950                 955                 960 


Thr Val Tyr Ile Glu Glu Thr Lys Thr Lys Leu Leu Lys Gln Gly Asn 
                965                 970                 975     


Phe Lys Ala Leu Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe 
            980                 985                 990         


Val Asp Thr Ser Ser Lys Ala Glu  Leu Lys Asp Lys Pro  Ile Ser Lys 
        995                 1000                 1005             


Ser Val  Val Glu Tyr Glu Leu  Gly Glu Tyr Gln Asn  Ala Arg Ile 
    1010                 1015                 1020             


Glu Thr  Ile Lys Asp Met Leu  Leu Leu Glu Glu Thr  Leu Ile Lys 
    1025                 1030                 1035             


Lys Tyr  Lys Thr Leu Pro Thr  Asn Lys Phe Ser Ala  Met Leu Asn 
    1040                 1045                 1050             


Gly Trp  Leu Glu Gly Lys Asp  Glu Ala Asp Lys Ala  Arg Phe Gln 
    1055                 1060                 1065             


Asn Asp  Val Lys Leu Leu Val  Ala Val Arg Asn Ala  Phe Ser His 
    1070                 1075                 1080             


Asn Gln  Tyr Pro Met Arg Asn  Arg Ile Ala Phe Ala  Asn Ile Asn 
    1085                 1090                 1095             


Pro Phe  Ser Leu Ser Ser Ala  Asn Thr Ser Glu Glu  Lys Lys Leu 
    1100                 1105                 1110             


Asp Ile  Ala Asn Gln Leu Lys  Asp Lys Thr His Lys  Thr Ile Glu 
    1115                 1120                 1125             


Lys Ile  Ile Glu Ile Glu Lys  Pro Ile Glu Thr Lys  Glu 
    1130                 1135                 1140     


<210>  2431
<211>  1101
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2431

Met Asp Asn Gly Lys Lys Tyr Arg Thr Leu Thr Asp Lys Tyr Tyr Phe 
1               5                   10                  15      


Ala Ala Tyr Leu Asn Met Ala Arg His Asn Thr Tyr Leu Ile Leu Ala 
            20                  25                  30          


Asp Ile Asn Thr Arg Leu Gly Phe Glu Lys Val Pro Pro Asp Asp Ala 
        35                  40                  45              


Met Ile Met Asp Met Pro Ile Ile Lys Lys Leu Lys Val Gly Gly Ala 
    50                  55                  60                  


Ala Gly Ala Ala Val Ile Val Pro Thr Asp Ile Gln Leu Met Ile Ile 
65                  70                  75                  80  


Lys Glu Leu His Gly His Phe Ala Phe Leu Lys Pro Met Leu Phe Ala 
                85                  90                  95      


Phe Lys Lys Pro Lys Gly Glu Ala Thr Glu Glu Glu Ile Gln Lys Met 
            100                 105                 110         


Glu Tyr Ala Pro Asn Asp Tyr Tyr Asn Phe Phe Lys Ile Phe Ala Asp 
        115                 120                 125             


Thr Leu Asn Asn Leu Arg Asn Glu Tyr Thr His Val Ala Pro Gln Pro 
    130                 135                 140                 


Phe Asp Leu Pro Ala Asp Leu Leu Asn Gly Leu Arg Val Thr Phe Asp 
145                 150                 155                 160 


Ala Gly Val Arg Lys Ala Lys Ala Arg Phe Asn Phe Asp Pro Lys Glu 
                165                 170                 175     


Ile Glu His Leu Val Arg Gln Gly Lys Gly Gly Lys Glu Lys Pro Thr 
            180                 185                 190         


Phe Lys Tyr Lys Phe Gln Glu Lys Gly Ser Thr Ser Leu Ser Ile Tyr 
        195                 200                 205             


Gly Ile Thr Phe Phe Ile Cys Leu Leu Leu Glu Arg Lys Tyr Val Thr 
    210                 215                 220                 


Leu Phe Thr Gln Lys Ile Gln Gly Ile Lys Gly Thr His Thr Arg Ile 
225                 230                 235                 240 


Phe Lys Ala Thr Tyr Glu Val Phe Ala Val His Ser Val Asn Leu Pro 
                245                 250                 255     


Lys Ala Arg Tyr Thr Ser Asp Ser Gly Asp Gly Ala Leu Leu Leu Asp 
            260                 265                 270         


Met Leu Asn Glu Leu Lys Lys Cys Pro Gly Ile Leu Phe Pro Gln Leu 
        275                 280                 285             


Gln Pro Ala His Gln Asp Ala Phe Arg Val Ser Ile Glu Gly Leu Pro 
    290                 295                 300                 


Gly Met Asp Glu Asp Gly Asp Ser Gly Phe Val Leu Leu Lys Arg His 
305                 310                 315                 320 


Glu Asp Arg Phe Thr Tyr Leu Ala Met Arg Phe Ile Asp Glu Val Lys 
                325                 330                 335     


Trp Phe Gln His Leu His Phe Pro Val Asp Leu Gly Asn Tyr His Tyr 
            340                 345                 350         


His Leu Tyr Asp Lys Thr Val Asp Gly Val Pro Arg Ile Gly Ser Leu 
        355                 360                 365             


Trp Lys Lys Met Ile Gly Tyr Gly Arg Leu Pro Asp Tyr Gln His Asp 
    370                 375                 380                 


Phe Leu Asn Lys Lys Leu Pro Ala Thr Trp Leu Glu Leu Trp Asn Asn 
385                 390                 395                 400 


His Glu Gln Lys Ala Glu Thr Ser Thr Ile Pro Tyr Met Pro Arg Thr 
                405                 410                 415     


Met Pro His Tyr His Leu Pro Asp Asp Asn Ile Ala Met Lys Ile Gly 
            420                 425                 430         


Ala Val Ser Val Thr Trp Pro Gln Val Asn Ile Ala Gly Asn Asp Lys 
        435                 440                 445             


Ser Lys Asn Lys Pro Gly Ile Lys Ser Gln Pro Asp Leu Leu Ile Ser 
    450                 455                 460                 


Lys Tyr Glu Leu Phe Ala Phe Ile Phe Tyr Gly Leu Leu Leu Gly Ala 
465                 470                 475                 480 


Gly His Lys Glu Leu Glu Asp Lys Leu Ile Asn Phe Val His Lys Arg 
                485                 490                 495     


Arg Gln Leu Tyr Arg Asn Ile Gln Glu Gly Lys Ile Thr Pro Ile Ser 
            500                 505                 510         


Leu Pro Pro Asp Thr Pro Lys Pro Asn Ala Asp Asp Lys Glu His Pro 
        515                 520                 525             


Lys Tyr Asn Lys Arg Lys Ala Glu Leu Asn Gln Lys Leu Ala Ala Asn 
    530                 535                 540                 


Gly Phe Thr Phe Thr Ala Asp Asp Leu Thr Asp Glu Ile Lys Cys Tyr 
545                 550                 555                 560 


Leu Met Gly Val Val Thr Glu Ser Phe Glu Glu Lys Ala Lys Tyr Arg 
                565                 570                 575     


Leu Ile Asp Leu Val Lys Glu Thr Glu Asn Leu Gln Glu Lys Ile Lys 
            580                 585                 590         


Arg Gln Leu Ser Glu Lys Arg Lys Leu Gly Ser Lys Lys Asp Ile Glu 
        595                 600                 605             


Ile Lys Ala Gly Ile Leu Ala Thr Tyr Leu Ala Lys Asp Ile Met Leu 
    610                 615                 620                 


Phe Gln Pro Ala Leu Lys Thr Glu Asp Ala Lys Ala Gln Gly Lys Ala 
625                 630                 635                 640 


Thr Thr Thr Leu Tyr Arg Val Leu Gln Ala Lys Leu Ala Leu Tyr Gly 
                645                 650                 655     


Ala Asn Val Asp Thr Leu Glu Arg Thr Phe Thr Glu Cys Gly Leu Leu 
            660                 665                 670         


Ala Gly Ile Asn Pro His Pro Phe Leu Asp Lys Val Val Lys Leu Lys 
        675                 680                 685             


Asn Lys Asn Ile Val Asp Phe Tyr Thr Ala Tyr Leu Ser Ala Arg Lys 
    690                 695                 700                 


Gln Tyr Leu Leu Lys Cys Gln Asn Asp Lys Lys Tyr Asp Ser Tyr Gln 
705                 710                 715                 720 


Trp Leu Lys Asn Asn Gln Ala Arg Ser Lys Lys Gln Pro Asp Phe Gly 
                725                 730                 735     


Lys Gln Leu Ala Gly Lys Met Leu Glu Leu Pro Val Ile Ile Pro Arg 
            740                 745                 750         


Gly Phe Phe Thr Glu Gly Ile Lys Lys Glu Leu Leu Ala Leu Asn Asn 
        755                 760                 765             


Glu Ser Leu Asn Asn Thr Ile Thr Asn Ala Arg Thr Pro Asn Ala Ser 
    770                 775                 780                 


Phe Met Phe Met Ala Tyr Leu Lys Asp His Gln Gly Asp Asp Met Gln 
785                 790                 795                 800 


Glu Phe Tyr Lys Trp Glu Arg Val Tyr Lys Ile Phe Asn Asn Tyr His 
                805                 810                 815     


Asp Ala Arg Ser Lys Thr Asn Lys Arg Asp Thr Leu Ala Ala Val Pro 
            820                 825                 830         


Leu Thr Glu Glu Glu Arg Lys Gly Gln Ile Lys Glu Leu Asn Glu Trp 
        835                 840                 845             


Val Asn Asn Gln Lys Ser Asp Glu Asp Phe Phe Lys Tyr Lys Arg Arg 
    850                 855                 860                 


Phe Asp Val Phe Glu Ser Asn Glu Lys Gln Ile Arg Gln Ile Lys Val 
865                 870                 875                 880 


Gln Asp Ile Ala Ile Ser Leu Met Cys Asp Asn Leu Leu Arg Ser Ile 
                885                 890                 895     


Asn Lys Asn Leu Ile Asn Thr Thr Gly Lys Phe Tyr Leu Lys Asp Ile 
            900                 905                 910         


Ser Pro Val Gly Glu Lys Gly Ile Leu Asp Met Pro Met Asn Asn Phe 
        915                 920                 925             


Gly Arg Val Phe Ser Tyr Ser Cys Ile Ser Pro Asp Pro Ala Asp Thr 
    930                 935                 940                 


Ala Ser Ile Ser Gly Asn Thr Arg Ile Ser Gln Asp Asp Leu Lys Val 
945                 950                 955                 960 


Lys Asn Ile Gly Asp Phe Asn Lys Phe Ile Lys Asp Arg Arg Leu Asn 
                965                 970                 975     


Asn Leu Leu Ala Tyr Met Gln Lys Ser Glu Ile Lys Arg Gln Glu Leu 
            980                 985                 990         


Glu Lys Glu Leu Glu Arg Tyr Asp  Leu Ile Arg Ala Asp  Ile Phe Lys 
        995                 1000                 1005             


Thr Ile  His Glu Phe Glu Ser  Met Ile Leu Thr Lys  Phe Pro Gly 
    1010                 1015                 1020             


Ile Asp  Gly Thr Lys Phe Glu  Ile Ile Ile Asp Gln  Tyr Gln Gln 
    1025                 1030                 1035             


Ile Ser  Gly Leu Pro Asn Ala  Arg Lys Glu Gln Ile  Lys Gln Ile 
    1040                 1045                 1050             


Arg His  Ala Phe Ser His Asn  Gln Tyr Pro Asn Pro  Ser His Phe 
    1055                 1060                 1065             


Leu Asp  Asp Glu Ser Ile Glu  Thr Val Gly Ser Gly  Asn Thr Arg 
    1070                 1075                 1080             


Tyr Tyr  Val Asp Tyr Phe Leu  Glu Phe Val Lys Thr  Asn Leu Leu 
    1085                 1090                 1095             


Lys Val  Ser 
    1100     


<210>  2432
<211>  1103
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2432

Met Asp Thr Pro Ser Ser Ile Glu Arg Lys His Ile Val Leu Thr Asp 
1               5                   10                  15      


Lys Tyr Tyr Phe Ala Ala Tyr Leu Asn Met Ala Arg His Asn Val Tyr 
            20                  25                  30          


Met Val Leu Thr Asp Ile Asn Thr Arg Leu Gly Phe Glu Lys Val Pro 
        35                  40                  45              


Gly Asp Asp Ala Gly Ala Val Ser Val Ile Val Leu Gln Lys Leu Lys 
    50                  55                  60                  


Glu Asp Ser Thr Lys Lys Asn Val Ile Ala Pro Asp Ile Gln Leu Lys 
65                  70                  75                  80  


Ile Ile Lys Glu Leu His Ala His Phe Ser Phe Leu Lys Pro Met Met 
                85                  90                  95      


Phe Ala Trp Lys Lys Pro Ile Gly Glu Ala Thr Glu Glu Glu Ile Gln 
            100                 105                 110         


Lys Met Glu Tyr Ala Pro Gly Asp Tyr Tyr Thr Phe Phe Ala Val Phe 
        115                 120                 125             


Leu Lys Ala Leu Asn Asp Leu Arg Asn Glu Tyr Thr His Val Ala Thr 
    130                 135                 140                 


Gln Pro Phe Asp Phe Pro Ala Asp Leu Leu His Ala Leu Arg Val Thr 
145                 150                 155                 160 


Phe Asp Ala Gly Val Arg Lys Ala Lys Ala Arg Phe Ser Phe Glu Ala 
                165                 170                 175     


Lys Asp Val Glu His Leu Val Arg Gln Val Lys Gly Gly Lys Glu Lys 
            180                 185                 190         


Pro Ala Phe Lys Tyr Lys Phe Gln Leu Lys Gly Ser Lys Ser Leu Thr 
        195                 200                 205             


Thr Tyr Gly Leu Ser Phe Phe Ile Cys Leu Leu Leu Glu Arg Lys Tyr 
    210                 215                 220                 


Ala Ser Leu Phe Thr Gln Lys Leu Glu Gly Leu Lys Asp Lys Arg Thr 
225                 230                 235                 240 


Arg Ala Phe Lys Ala Thr Tyr Glu Val Phe Ala Val His Cys Ile Thr 
                245                 250                 255     


Leu Pro Lys Ala Arg Tyr Thr Ser Asp Ser Gly Glu Gly Ser Leu Leu 
            260                 265                 270         


Leu Asp Met Leu Asn Glu Leu Lys Arg Cys Pro Asp Ile Leu Phe Pro 
        275                 280                 285             


His Leu Gln Ala Lys Asn Gln Asp Val Phe Arg Ile Pro Val Glu Asp 
    290                 295                 300                 


Val Pro Gly Met Glu Gln Glu Glu Asp Asn Asn Phe Val Leu Leu Lys 
305                 310                 315                 320 


Arg Tyr Glu Asp Arg Phe Pro Tyr Leu Ala Leu Arg Phe Met Asp Glu 
                325                 330                 335     


Val Lys Trp Phe Gln Lys Leu His Phe Pro Val Asp Leu Gly Asn Tyr 
            340                 345                 350         


His Tyr His Leu Tyr Asp Lys Thr Val Asp Gly Met Pro Arg Val Gly 
        355                 360                 365             


Ser Leu Trp Glu Lys Met Ile Gly Tyr Gly Arg Leu Pro Asp Tyr Gln 
    370                 375                 380                 


Gln Ala Phe Leu Glu Lys Lys Val Pro Asp Ser Trp Leu Arg Leu Trp 
385                 390                 395                 400 


Lys Asn His Glu Val Arg Thr Glu Gly Ala Lys Ala Pro Tyr Ile Pro 
                405                 410                 415     


Pro Ala Met Pro His Tyr His Leu Pro Asp Asn Asn Ile Ala Ile Arg 
            420                 425                 430         


Ile Thr Thr Glu Asn Gly Trp Pro Asp Leu Thr Ile Asn Glu Ala Asp 
        435                 440                 445             


Ala Asp Lys Asn Lys Pro Gly Lys Lys His Gln Pro Asp Met Leu Ile 
    450                 455                 460                 


Ser Lys Tyr Glu Leu Phe Gly Leu Ile Phe Tyr Gly Leu Leu Leu Gly 
465                 470                 475                 480 


Asp Ala Asp Ala Ile Arg Lys Asn Leu Glu Asp Lys Leu Val His Tyr 
                485                 490                 495     


Val His Glu Arg Lys Arg Leu Tyr Arg Glu Ile Gln Asn Gly Lys Met 
            500                 505                 510         


Met Pro Ile Ala Leu Pro Pro Asp Val Pro Lys Pro Ser Val Asp Gly 
        515                 520                 525             


Lys Lys His Pro Lys Tyr Asp Leu Arg Lys Ser Glu Leu Asn Lys Lys 
    530                 535                 540                 


Leu Ala Ala Asn Gly Phe Thr Phe Thr Ala Asp Asp Leu Pro Asp Glu 
545                 550                 555                 560 


Ile Lys Cys Phe Leu Met Gly Ile Val Thr Glu Ser Phe Glu Glu Lys 
                565                 570                 575     


Ala Lys Tyr Leu Leu Arg Asp Leu Leu Glu Glu Thr Glu Gly Leu Tyr 
            580                 585                 590         


Glu Arg Val Asn Arg Gln Leu Thr Glu Lys Arg Lys Leu Gly Ser Trp 
        595                 600                 605             


Lys Asp Val Glu Ile Lys Ser Gly Val Leu Ala Thr Phe Leu Ala Lys 
    610                 615                 620                 


Asp Ile Met Arg Phe Gln Pro Ala Ile Thr Asp Ala Gly Ile Lys Ala 
625                 630                 635                 640 


Asn Gly Lys Ala Thr Ser Thr Leu Tyr Lys Val Leu Gln Ala Lys Leu 
                645                 650                 655     


Ala Leu Tyr Gly Ala Asn Ile Asp Thr Leu Glu Arg Thr Phe Ile Glu 
            660                 665                 670         


Cys Lys Leu Ile Gly Gly Ser Asn Pro His Pro Phe Leu Glu Lys Val 
        675                 680                 685             


Val Asn Phe Lys Lys Gly Thr Ile Val Asp Phe Tyr Ile Val Tyr Leu 
    690                 695                 700                 


Gln Glu Arg Lys Lys Tyr Leu Ser Lys Cys Gln Glu Asp Lys Lys Tyr 
705                 710                 715                 720 


Ser Thr Tyr Gln Trp Leu Lys Asn Asn Gln Ala Arg Ser Lys Val Leu 
                725                 730                 735     


Pro Asp Phe Gly Lys Gln Leu Ala Lys Asn Met Leu Glu Val Pro Val 
            740                 745                 750         


Val Ile Pro Arg Gly Phe Phe Thr Gln Gly Ile Lys Ser Ile Leu Thr 
        755                 760                 765             


Ser Leu Asn Asn Glu Lys Leu Asn Asp Val Leu Asn Asn Ala Arg Thr 
    770                 775                 780                 


Pro Asn Asn Ser Phe Met Leu Ile Asn Tyr Leu Gln His Cys His Asn 
785                 790                 795                 800 


Asp Asp Leu Gln Glu Phe Tyr Gly Trp Glu Arg Val Tyr Lys Ile Phe 
                805                 810                 815     


Asn Asn Tyr Tyr Asp Gln Arg Thr Lys Lys Asp Leu Gln Thr Ala Leu 
            820                 825                 830         


Thr Gln Val Pro Leu Ser Glu Gln Asn Arg Lys Glu Ile Phe Lys Glu 
        835                 840                 845             


Val Ser Asp Trp Val Asn Ser Ile Lys Asp Asn Asp Glu Tyr Ile Lys 
    850                 855                 860                 


Tyr Lys Asn Arg Phe Asp Ala Phe Glu Ser Asn Glu Lys Gln Ile Arg 
865                 870                 875                 880 


Gln Val Lys Val Gln Asp Ile Ala Leu Phe Leu Met Ser Asn His Leu 
                885                 890                 895     


Leu Lys Ser Ile Asn Lys Asn Leu Ile Lys Thr Asp Gly Arg Phe Tyr 
            900                 905                 910         


Leu Lys Asp Ile Ser Pro Asn Gly Asp Lys Gly Ile Leu Asp Thr Pro 
        915                 920                 925             


Met Asp Asn Phe Gly Arg His Phe Leu Tyr Ser Cys Ser Ile Val Ser 
    930                 935                 940                 


Asp Ala Gly Val Pro Val Tyr Gly Thr Thr Lys Ile Tyr Gln Asn Asp 
945                 950                 955                 960 


Leu Lys Val Lys Asn Ile Gly Asp Phe Asn Lys Phe Ile Arg Asp Arg 
                965                 970                 975     


Arg Leu Asn Asn Leu Leu Gly Tyr Ile Gln Gln Ala Glu Ile Asn Arg 
            980                 985                 990         


Pro Leu Leu Glu Lys Glu Leu Glu  Arg Tyr Asp Thr Val  Arg Val Asp 
        995                 1000                 1005             


Ile Phe  Lys Ile Ile His Asp  Phe Glu Ser Gln Ile  Leu Ala Leu 
    1010                 1015                 1020             


Ala Pro  Ala Ile Asp Gly Lys  Asn Phe Asp Asn Ile  Ile Ala Phe 
    1025                 1030                 1035             


His Gln  Gln Gln Thr Asn Leu  Pro Asp Lys Leu Ile  Lys Gln Ile 
    1040                 1045                 1050             


Lys Lys  Ile Arg Asp Ala Phe  Ser His Asn Glu Tyr  Pro Asn Pro 
    1055                 1060                 1065             


Leu Phe  Phe Leu Asp Glu Asn  Asn Thr Leu Pro Gly  Lys Glu Glu 
    1070                 1075                 1080             


Lys Leu  Tyr Phe Ala Asp Tyr  Phe His Asp Phe Ile  Lys Asn Asn 
    1085                 1090                 1095             


Leu Lys  Thr Val Lys 
    1100             


<210>  2433
<211>  1160
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2433

Met Lys Asn Glu Ile Leu Thr Asn Ser Lys Ser Leu Lys Ser Asn Pro 
1               5                   10                  15      


Asp Tyr Phe Ser Ala Tyr Leu Asn Met Ala Arg His Asn Ala Tyr Leu 
            20                  25                  30          


Ile Leu Ser His Ile Ser Asp Lys Leu Lys Pro Lys Lys Thr Asn Thr 
        35                  40                  45              


Pro Glu Asp Ala Leu His Ser Ala Tyr Ala Leu Glu Val Leu Lys Ser 
    50                  55                  60                  


Ser Lys Glu Pro Asp Ile Thr Ala Lys Ser Ile Lys Met Leu Asn Glu 
65                  70                  75                  80  


His Phe Pro Phe Leu Lys Val Met Phe Asp Thr Asn Ser Ile Thr Glu 
                85                  90                  95      


Lys Ser Lys Gly Ser Lys Gly Ile Tyr Ser Glu Lys Leu Pro Glu Gln 
            100                 105                 110         


Tyr Leu Asp Lys Met Met Leu Leu Leu Asp His Leu Asn Asn Tyr Arg 
        115                 120                 125             


Asn Ser Tyr Thr His Cys Val His Ile Pro Ile Ile Asn Asp Lys Asn 
    130                 135                 140                 


Phe Ile Tyr Cys Leu Asn Asn Ile Phe Asp Ala Ser Val Arg Thr Val 
145                 150                 155                 160 


Lys Asp Arg Phe Glu Phe Ser Glu Asn Asp Val Ser His Leu Arg Arg 
                165                 170                 175     


Tyr Glu Gln Val Phe Asp Pro Glu Thr Lys Lys Arg Lys Ala Ser Arg 
            180                 185                 190         


Lys Lys Asp Phe Lys Tyr Asn Phe Ile Asp Asn Asp Asp Ile Ser Glu 
        195                 200                 205             


Lys Gly Ile Ala Phe Phe Ile Ala Leu Phe Leu Glu Lys Lys His Ala 
    210                 215                 220                 


Phe Glu Phe Leu Lys Lys Leu Ser Asp Phe Lys Asp Ser Arg Thr Lys 
225                 230                 235                 240 


Met Met Gln Ala Thr Leu Glu Ser Tyr Cys Val Tyr His Ile Arg Leu 
                245                 250                 255     


Pro Lys Glu Arg Ile Glu Asn Thr Gln Asn Asp Leu Ser Leu Cys Leu 
            260                 265                 270         


Asp Ile Phe Asn Glu Leu Lys Lys Cys Pro Ser Glu Leu Phe Asp Leu 
        275                 280                 285             


Leu Lys Lys Glu Asp Ala Glu Lys Phe Arg Ile Lys Pro Asp Ile Asn 
    290                 295                 300                 


Asn Leu Asn Asp Glu Asp Ser Gly Asn Ile Val Glu Asn Ser Thr Asp 
305                 310                 315                 320 


Asp Tyr Asn Val Glu Pro Ile Leu Lys Arg Tyr Ser Asn Arg Phe Pro 
                325                 330                 335     


Tyr Leu Ala Met Arg Tyr Ile Asp Glu Lys Lys Val Phe Gln Lys Leu 
            340                 345                 350         


Arg Phe His Val Asp Leu Gly Asn Tyr Tyr Phe Lys Phe Tyr Pro Lys 
        355                 360                 365             


Thr Thr Val Asp Gly Glu Lys Arg Asp Arg Ser Leu Lys Val His Leu 
    370                 375                 380                 


Asn Ser Phe Gly Arg Leu Asp Asp Leu Asn His Ala Arg Leu Val Glu 
385                 390                 395                 400 


Trp Asn Asp Leu Ile Arg Phe His Lys Glu Glu Glu Asp Glu Asn Pro 
                405                 410                 415     


Ile Glu Glu Leu Met Pro Tyr Ile Thr Asp Thr Tyr Pro His Tyr His 
            420                 425                 430         


Leu His Asn Asn Gln Ile Gly Leu Lys Asp Thr Gln Asn Asn Pro Asp 
        435                 440                 445             


Lys Leu Leu Pro Lys Ile Glu Arg Glu Lys Thr Lys Thr Glu Gln Pro 
    450                 455                 460                 


Asp Phe Trp Leu Ser Thr Tyr Glu Leu Pro Ala Leu Leu Phe Tyr Ser 
465                 470                 475                 480 


Tyr Leu Leu Lys Lys Lys Arg Asp Ile Ser Ala Glu Asp Leu Ile Leu 
                485                 490                 495     


Asn Cys Arg Lys Lys Tyr His Thr Leu Phe Lys Leu Ile Ser Glu Gly 
            500                 505                 510         


Asn Gly Pro Glu Ile Lys Glu Cys Gln Val Thr Ile Lys Gln Lys Gly 
        515                 520                 525             


Lys Asn Ile Ser Val Phe Leu Leu Thr Ala His Phe Glu Asp Glu Thr 
    530                 535                 540                 


Gly Lys Ser His Glu Ile Glu Leu Asn Asp Leu Pro Gln Val Phe Gln 
545                 550                 555                 560 


Asn Tyr Leu Thr Asp Lys Gln Leu His Asn Arg Glu Glu Leu Ala Glu 
                565                 570                 575     


Asn Lys Ile Asn Arg Leu Ile Ile Glu Thr Glu Arg Arg Arg Glu Lys 
            580                 585                 590         


Ile Asn Lys Asp Leu Glu Arg Ile Asn Gly Leu Lys Gly Asn Lys Arg 
        595                 600                 605             


Gly Lys Lys Asn Phe Val Glu Ile Lys Ser Gly Met Leu Ala Asp Phe 
    610                 615                 620                 


Leu Ala Lys Asp Thr Ile Arg Leu Gln Pro Ser Ile Asp Ala Ile Gly 
625                 630                 635                 640 


Lys Asp Lys Ile Thr Gly Leu Asn Phe Gln Ile Leu Gln Ser His Leu 
                645                 650                 655     


Ala Phe Tyr Gly Arg Asp Phe Leu Met Leu Lys Asp Ile Phe Arg Gln 
            660                 665                 670         


Cys Lys Leu Val Asp Ala Gln Ile Ser His Pro Phe Leu Tyr Lys Leu 
        675                 680                 685             


Asn Pro Glu Asp His Phe Asp Ile Val Ser Phe Tyr Lys Ala Tyr Leu 
    690                 695                 700                 


Gly Glu Arg Lys Lys Tyr Leu Glu Gln Cys Asn Arg Asn Lys Asp Tyr 
705                 710                 715                 720 


Lys Ser Tyr Tyr Phe Leu Lys Phe Asn Ser Gln Lys Phe Thr Thr Glu 
                725                 730                 735     


Thr Ile Glu Tyr Cys Lys Asp Leu Ala Lys Lys Leu Met Asn Thr His 
            740                 745                 750         


Ser Gln Asp Asn His Pro Ile Asn Leu Pro Arg Gly Met Phe Met Asp 
        755                 760                 765             


Ala Ile Ile Asp Trp Phe Lys Lys His Gly Asp Pro Gln Leu Gln Ala 
    770                 775                 780                 


Ile Ala Lys Thr Glu Arg Val Asn Ala Val Tyr Leu Ile Gln Lys Phe 
785                 790                 795                 800 


Phe Glu Phe Lys Lys Asp Ser Asn Gln Pro Phe Tyr Asp Tyr Pro Arg 
                805                 810                 815     


Ser Tyr Asp Phe Ile Asp Lys Leu Glu Asn Phe Asn Asn Met Arg Cys 
            820                 825                 830         


Gly Arg Pro Leu Leu Leu Gln Arg Lys Tyr Tyr Ser Ile Gln Gln Leu 
        835                 840                 845             


Ala Asp Lys Ile Asp Asp Val Lys Thr Arg Ile Thr Lys Leu Pro Glu 
    850                 855                 860                 


Ser Glu Pro Asn Asp Ser His Pro Arg Lys Arg Met Leu Ala Thr Leu 
865                 870                 875                 880 


Ser Asp Tyr Lys Gln Asn Glu Lys Leu Leu Arg Leu Tyr Lys Thr Gln 
                885                 890                 895     


Asp Arg Ile Leu Phe Leu Val Ala Ser Asp Ile Leu Phe Ala Gln Lys 
            900                 905                 910         


Pro Gln Gly Leu Glu Glu Asn Asp Leu Lys Leu Ser Asn Val Lys Pro 
        915                 920                 925             


Lys Pro Glu Asn Asp Ser Asp Glu Asp Leu Leu Ser Ser Gln Leu Pro 
    930                 935                 940                 


Phe Arg Phe Pro Tyr Gln Tyr Trp Asp Val Thr Ser Lys Gly Glu Ile 
945                 950                 955                 960 


Asp His Lys Asn Lys Ile Gly Glu Val Ile Ile Phe Gln Lys Lys Leu 
                965                 970                 975     


Lys Leu Lys Asn Tyr Gly Asp Phe Ile Arg Tyr Thr Lys Asp Arg Arg 
            980                 985                 990         


Leu Asn Asn Leu Phe His Trp Thr  Gly Asp Ile Glu Leu  Glu Met Pro 
        995                 1000                 1005             


Val Leu  Gln Lys Glu Leu Glu  Arg Tyr Glu Glu Ala  Arg Leu Thr 
    1010                 1015                 1020             


Val Phe  Arg Leu Ile His Asp  Phe Glu Lys Ala Met  Tyr Glu Lys 
    1025                 1030                 1035             


His His  Leu Phe Phe Asp Glu  Leu Leu Lys Thr Asn  Lys Leu Lys 
    1040                 1045                 1050             


Lys Glu  Asn Glu Asn Glu Asn  Ser Tyr Ile Asn His  Glu Glu Met 
    1055                 1060                 1065             


Leu Glu  Lys Phe Phe Ser Asp  Tyr Pro Glu Leu Ile  His Tyr Glu 
    1070                 1075                 1080             


Asp Val  Met Leu Thr Ile Arg  Asn Cys Phe Ser His  Asn Gln Tyr 
    1085                 1090                 1095             


Pro Val  Lys Cys Ala Phe Asp  Asn Ile Asp Ser Ile  Gly Leu Phe 
    1100                 1105                 1110             


Glu Gly  Cys Pro Asp Ile Glu  Ser Asp His Asp Asn  Glu Leu Asn 
    1115                 1120                 1125             


Ile Ala  Met Arg Ile Lys Asn  His Ala Ile Ala Thr  Tyr Gly Glu 
    1130                 1135                 1140             


Phe Ile  Lys Ile Leu Thr Asn  Leu Thr Pro Ile His  Asp Ile Asn 
    1145                 1150                 1155             


Val Ser  
    1160 


<210>  2434
<211>  1145
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2434

Met Glu Thr Leu Thr Ile Pro Glu Val Ile Lys Cys Arg Thr Leu Ser 
1               5                   10                  15      


Asp Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Ile Ala Lys Glu Phe Asp Leu Pro Leu 
        35                  40                  45              


Leu Ala Glu Glu Gly His Leu Lys Asn Ser Phe Leu Cys Lys Lys Glu 
    50                  55                  60                  


His Asn Lys Val Asn Trp Asn His Val Tyr Ser Arg Thr Lys Arg Phe 
65                  70                  75                  80  


Leu Ala Val Leu Lys Val Phe Asp Ala Glu Thr Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Lys Thr Ile Asn Trp Glu Gly Lys Asp Phe Ala Ser Met Ser Asp 
            100                 105                 110         


Ile Leu Lys Ile Val Phe Gly Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Thr Ile Arg Lys Thr Ala Val 
    130                 135                 140                 


Ser Ala Glu Met Ala Leu Phe Leu Thr Thr Asn Phe Arg Arg Ala Ile 
145                 150                 155                 160 


Glu Tyr Thr Lys Glu Arg Phe Lys Gly Val Leu Asn Asp Glu Asp Tyr 
                165                 170                 175     


Gln Leu Val Ala Ser Lys Lys Val Leu Glu Ala Asn Ser Thr Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Arg Phe Ile Gly Ile Ile Thr Gly Leu Lys Gly Thr Gln Asn 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro His Asp Arg Phe Gln Ser Asp Asn Pro Arg Gln Ala Phe Ser 
                245                 250                 255     


Leu Asp Leu Ile Asn Glu Leu Asn Arg Cys Pro Lys Val Leu Tyr Asn 
            260                 265                 270         


Ala Ile Thr Glu Glu Gly Lys Gln Lys Leu Arg Ser Ile Pro Gly Glu 
        275                 280                 285             


Leu Glu Asn Lys Asn Leu His Asp Asn Asn Thr Lys Lys Glu Ala Lys 
    290                 295                 300                 


Ile Glu Ala Glu Ala Tyr Glu Leu Tyr Ile Glu Ser Leu Thr Arg Gln 
305                 310                 315                 320 


Ile Arg Tyr Ser Asn Arg Phe Pro Asp Phe Ala Leu Lys Phe Ile Asp 
                325                 330                 335     


Glu Thr Asp Ile Phe Ser Glu Phe Arg Phe Gln Ile Asp Leu Gly Lys 
            340                 345                 350         


Leu Leu Val Asp Glu Tyr Leu Lys Phe Phe Asn Gly Glu His Val Gln 
        355                 360                 365             


Arg Arg Ile Val Glu Asn Ala Lys Ala Phe Gly Lys Leu Ile Asp Phe 
    370                 375                 380                 


Asn Asp Glu Ala Lys Val Met Thr Arg Ile Gly Asn Gly His Phe Ser 
385                 390                 395                 400 


Lys Arg Phe Glu Gln Phe Ala Pro Phe Tyr Asn Thr Glu Asp Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Arg His His Val Thr Ala Lys Leu Gly Pro Asp Ser 
            420                 425                 430         


Lys Gly Glu Pro Glu Lys Lys Leu Leu Gln Pro Leu Pro Glu Ala Phe 
        435                 440                 445             


Leu Ser Leu His Glu Leu Pro Lys Val Ile Leu Leu Asp Tyr Leu Gln 
    450                 455                 460                 


Lys Gly Glu Pro Glu Lys Leu Ile Asn Asp Phe Ile Leu Ile Asn Asn 
465                 470                 475                 480 


Ser Lys Leu Met Asn Met Ser Phe Ile Glu Ala Val Lys Thr Gln Leu 
                485                 490                 495     


Pro Pro Glu Trp Asp Glu Phe Gln Arg Arg Thr Gly Ser Lys Asn Glu 
            500                 505                 510         


Met Pro Tyr Asn Glu Lys Thr Leu Ala Tyr Leu Leu Gln Arg Lys Gln 
        515                 520                 525             


Ile Leu Asn Lys Ile Leu Ala Glu Phe Gln Leu Asn Asp Lys Gln Ile 
    530                 535                 540                 


Pro Gly Arg Ile Leu Asp Tyr Trp Leu Asn Ile Ala Asp Val Glu Glu 
545                 550                 555                 560 


Glu Arg Ala Val Ser Asp Arg Ile Lys Ser Ile Lys Arg Asp Cys Met 
                565                 570                 575     


Ser Arg Leu Arg Ala Leu Gly Lys Phe Lys Ile Asp Arg Asn Arg Asn 
            580                 585                 590         


Lys Ile Pro Lys Ile Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile 
        595                 600                 605             


Val Asp Met Val Val Ser Glu Gly Lys Lys His Lys Ile Thr Ser Phe 
    610                 615                 620                 


Tyr Tyr Glu Lys Met Gln Asp Cys Leu Ser Leu Phe Ala Asp Pro Leu 
625                 630                 635                 640 


Lys Arg Gln Leu Phe Ile His Ile Ile Thr Asn Glu Leu Arg Leu Asn 
                645                 650                 655     


Asp Ser Gly Gly His Pro Phe Leu Phe Lys Leu Asn Met Arg Gln Ile 
            660                 665                 670         


Asn Cys Thr Ser Asp Phe Tyr Glu Ile Tyr Leu Gln Glu Lys Gly His 
        675                 680                 685             


Lys Met Val Pro Glu Lys Asn Leu Lys Thr Gly Lys Val Val Asn Thr 
    690                 695                 700                 


Asp His Ser Trp Met Ala Leu Thr Phe Tyr Lys Leu Glu Phe Asn Asp 
705                 710                 715                 720 


Lys Val Asp Lys Leu Met Thr Val Val Lys Leu Pro Leu Asn Lys Leu 
                725                 730                 735     


Asn Leu Pro Phe Thr Leu Arg Gln Leu Asn Ala Lys Thr Thr Tyr Thr 
            740                 745                 750         


Leu Glu Gln Trp Leu Lys Asn Leu Thr Leu Gly Lys Lys Pro Asp Asp 
        755                 760                 765             


Gly Lys His Pro Val Asn Leu Pro Thr Asn Leu Phe Asp Glu Lys Leu 
    770                 775                 780                 


Ser Asp Leu Leu Arg Gln Asp Leu Asp Asn Asn Lys Ile Ala Tyr Arg 
785                 790                 795                 800 


Pro Tyr Ala Asn Trp Asn Glu Leu Phe Lys Ile Trp Trp Ile Ser Arg 
                805                 810                 815     


Asn Asp Ser Leu Gln Arg Phe Tyr Asn Ala Glu Arg Glu Tyr His Ile 
            820                 825                 830         


Phe Asn Glu Lys Val Asn Phe Tyr Pro Asn Arg Lys Glu Asn Phe Ala 
        835                 840                 845             


Asp Tyr Tyr Gln His Ala Val Lys Val Ala Phe Gln Lys Lys Arg Asn 
    850                 855                 860                 


Glu Arg Ile Ile Glu Gln Arg Ile Asn Lys Tyr Leu Pro Asp Ile Leu 
865                 870                 875                 880 


Phe Glu Gln Val Glu Lys Thr Phe Lys His Thr Ile Ala Glu Thr Glu 
                885                 890                 895     


Lys Glu Ile Arg Ile Leu Gln Glu Glu Asp Arg Ile Met Leu Leu Met 
            900                 905                 910         


Leu Glu Gly Leu Met Glu Asp Gly Asn Lys Gln Gln Leu Lys Leu Ser 
        915                 920                 925             


Glu Ile Lys Thr Leu Gln Asn Ala Thr Ile Asn Ile Arg Gln Leu Val 
    930                 935                 940                 


Pro Gly Lys Leu Ser Phe Asp Asp Ser Gly Glu Ala Ile Lys Asp Ser 
945                 950                 955                 960 


Thr Asn Pro Glu Ile Val Arg Thr Val Ser Val Ser Ile Lys Arg Ile 
                965                 970                 975     


Glu Tyr Asn Leu Leu Pro Lys Tyr Val Ala Asp Gly Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Pro Asp Glu  Glu Ile Gln Met Glu  Arg Leu Lys 
        995                 1000                 1005             


Thr Glu  Phe Asp Thr Tyr Asn  Lys Val Arg Gln Val  Val Leu Asp 
    1010                 1015                 1020             


Leu Ser  Phe Lys Leu Glu Lys  Met Ile Ile Glu Lys  Gly His Lys 
    1025                 1030                 1035             


Asp Arg  Ile Asn Gln Leu Cys  Thr Gly Ala Thr Gly  Glu Leu Leu 
    1040                 1045                 1050             


Thr Gly  Asn Ile Cys His His  Thr Tyr Leu Thr Trp  Leu Lys Asp 
    1055                 1060                 1065             


Lys Glu  Met Ile Asp Asn Glu  Thr Phe Ile Phe Met  Asn Met Val 
    1070                 1075                 1080             


Gln His  Cys Phe Ser His Asn  Gln Tyr Pro Gln Lys  Lys Thr Met 
    1085                 1090                 1095             


Glu Arg  Ile Ile Asn His Trp  Glu Pro Asp Arg Phe  Ala Leu Thr 
    1100                 1105                 1110             


Ile Ala  Ala Thr Tyr Asn Gln  Lys Ile Ala Gly Ile  Leu Glu Asp 
    1115                 1120                 1125             


Ile Gly  Thr Phe Pro Phe Ile  Arg Ser Arg Lys Thr  Met Pro Asp 
    1130                 1135                 1140             


Val Val  
    1145 


<210>  2435
<211>  1145
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2435

Met Glu Thr Leu Thr Ile Pro Glu Val Ile Lys Cys Arg Thr Leu Ser 
1               5                   10                  15      


Asp Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Ile Ala Lys Glu Phe Asp Leu Pro Leu 
        35                  40                  45              


Leu Ala Glu Glu Gly His Leu Lys Asn Ser Phe Leu Cys Lys Lys Glu 
    50                  55                  60                  


His Asn Lys Val Asn Trp Asn His Val Tyr Ser Arg Thr Lys Arg Phe 
65                  70                  75                  80  


Leu Ala Val Leu Lys Val Phe Asp Ala Glu Thr Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Lys Thr Ile Asn Trp Glu Gly Lys Asp Phe Ala Ser Met Ser Asp 
            100                 105                 110         


Ile Leu Lys Ile Val Phe Gly Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Thr Ile Arg Lys Thr Ala Val 
    130                 135                 140                 


Ser Ala Glu Met Ala Leu Phe Leu Thr Thr Asn Phe Arg Arg Ala Ile 
145                 150                 155                 160 


Glu Tyr Thr Lys Glu Arg Phe Lys Gly Val Leu Asn Asp Glu Asp Tyr 
                165                 170                 175     


Gln Leu Val Ala Ser Lys Lys Val Leu Glu Ala Asn Ser Thr Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Arg Phe Ile Gly Ile Ile Thr Gly Leu Lys Gly Thr Gln Asn 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro His Asp Arg Phe Gln Ser Asp Asn Pro Arg Gln Ala Phe Ser 
                245                 250                 255     


Leu Asp Leu Ile Asn Glu Leu Asn Arg Cys Pro Lys Val Leu Tyr Asn 
            260                 265                 270         


Ala Ile Thr Glu Glu Gly Lys Gln Lys Leu Arg Ser Ile Pro Gly Glu 
        275                 280                 285             


Leu Glu Asn Lys Asn Leu His Asp Asn Asn Thr Lys Lys Glu Ala Lys 
    290                 295                 300                 


Ile Glu Ala Glu Ala Tyr Glu Leu Tyr Ile Glu Ser Leu Thr Arg Gln 
305                 310                 315                 320 


Ile Arg Tyr Ser Asn Arg Phe Pro Asp Phe Ala Leu Lys Phe Ile Asp 
                325                 330                 335     


Glu Thr Asp Ile Phe Ser Glu Phe Arg Phe Gln Ile Asp Leu Gly Lys 
            340                 345                 350         


Leu Leu Val Asp Glu Tyr Leu Lys Phe Phe Asn Gly Glu His Val Gln 
        355                 360                 365             


Arg Arg Ile Val Glu Asn Ala Lys Ala Phe Gly Lys Leu Ile Asp Phe 
    370                 375                 380                 


Asn Asp Glu Ala Lys Val Met Thr Arg Ile Gly Asn Gly His Phe Ser 
385                 390                 395                 400 


Lys Arg Phe Glu Gln Phe Ala Pro Phe Tyr Asn Thr Glu Asp Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Arg His His Val Thr Ala Lys Leu Gly Pro Asp Ser 
            420                 425                 430         


Lys Gly Glu Pro Glu Lys Lys Leu Leu Gln Pro Leu Pro Glu Ala Phe 
        435                 440                 445             


Leu Ser Leu His Glu Leu Pro Lys Val Ile Leu Leu Asp Tyr Leu Gln 
    450                 455                 460                 


Lys Gly Glu Pro Glu Lys Leu Ile Asn Asp Phe Ile Leu Ile Asn Asn 
465                 470                 475                 480 


Ser Lys Leu Met Asn Met Ser Phe Ile Glu Ala Val Lys Thr Gln Leu 
                485                 490                 495     


Pro Pro Glu Trp Asp Glu Phe Gln Arg Arg Thr Gly Ser Lys Asn Glu 
            500                 505                 510         


Met Pro Tyr Asn Glu Lys Thr Leu Ala Tyr Leu Leu Gln Arg Lys Gln 
        515                 520                 525             


Ile Leu Asn Lys Ile Leu Ala Glu Phe Gln Leu Asn Asp Lys Gln Ile 
    530                 535                 540                 


Pro Gly Arg Ile Leu Asp Tyr Trp Leu Asn Ile Ala Asp Val Glu Glu 
545                 550                 555                 560 


Glu Arg Ala Val Ser Asp Arg Ile Lys Ser Ile Lys Arg Asp Cys Met 
                565                 570                 575     


Ser Arg Leu Arg Ala Leu Gly Lys Phe Lys Ile Asp Arg Asn Arg Asn 
            580                 585                 590         


Lys Ile Pro Lys Ile Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile 
        595                 600                 605             


Val Asp Met Val Val Ser Glu Gly Lys Lys His Lys Ile Thr Ser Phe 
    610                 615                 620                 


Tyr Tyr Glu Lys Met Gln Asp Cys Leu Ser Leu Phe Ala Asp Pro Leu 
625                 630                 635                 640 


Lys Arg Gln Leu Phe Ile His Ile Ile Thr Asn Glu Leu Arg Leu Asn 
                645                 650                 655     


Asp Ser Gly Gly His Pro Phe Leu Phe Lys Leu Asn Met Arg Gln Ile 
            660                 665                 670         


Asn Cys Thr Ser Asp Phe Tyr Glu Ile Tyr Leu Gln Glu Lys Gly His 
        675                 680                 685             


Lys Met Val Pro Glu Lys Asn Leu Lys Thr Gly Lys Val Val Asn Thr 
    690                 695                 700                 


Asp His Ser Trp Met Ala Leu Thr Phe Tyr Lys Leu Glu Phe Asn Asp 
705                 710                 715                 720 


Lys Val Asp Lys Leu Met Thr Val Val Lys Leu Pro Leu Asn Lys Leu 
                725                 730                 735     


Asn Leu Pro Phe Thr Leu Arg Gln Leu Asn Ala Lys Thr Thr Tyr Thr 
            740                 745                 750         


Leu Glu Gln Trp Leu Lys Asn Leu Thr Leu Gly Lys Lys Pro Asp Asp 
        755                 760                 765             


Gly Lys His Pro Val Asn Leu Pro Thr Asn Leu Phe Asp Glu Lys Leu 
    770                 775                 780                 


Ser Asp Leu Leu Arg Gln Asp Leu Asp Asn Asn Lys Ile Ala Tyr Arg 
785                 790                 795                 800 


Pro Tyr Ala Asn Trp Asn Glu Leu Phe Lys Ile Trp Trp Ile Ser Arg 
                805                 810                 815     


Asn Asp Ser Leu Gln Arg Phe Tyr Asn Ala Glu Arg Glu Tyr His Ile 
            820                 825                 830         


Phe Asn Glu Lys Val Asn Phe Tyr Pro Asn Arg Lys Glu Asn Phe Ala 
        835                 840                 845             


Asp Tyr Tyr Gln His Ala Val Lys Val Ala Phe Gln Lys Lys Arg Asn 
    850                 855                 860                 


Glu Arg Ile Ile Glu Gln Arg Ile Asn Lys Tyr Leu Pro Asp Ile Leu 
865                 870                 875                 880 


Phe Glu Gln Val Glu Lys Thr Phe Lys His Thr Ile Ala Glu Thr Glu 
                885                 890                 895     


Lys Glu Ile Arg Ile Leu Gln Glu Glu Asp Arg Ile Met Leu Leu Met 
            900                 905                 910         


Leu Glu Gly Leu Met Glu Asp Gly Asn Lys Gln Gln Leu Lys Leu Ser 
        915                 920                 925             


Glu Ile Lys Thr Leu Gln Asn Ala Thr Ile Asn Ile Arg Gln Leu Val 
    930                 935                 940                 


Pro Gly Lys Leu Ser Phe Asp Asp Ser Gly Glu Ala Ile Lys Asp Ser 
945                 950                 955                 960 


Thr Asn Pro Glu Ile Val Arg Thr Val Ser Val Ser Ile Lys Arg Ile 
                965                 970                 975     


Glu Tyr Asn Leu Leu Pro Lys Tyr Val Ala Asp Gly Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Pro Asp Glu  Glu Ile Gln Met Glu  Arg Leu Lys 
        995                 1000                 1005             


Thr Glu  Phe Asp Thr Tyr Asn  Lys Val Arg Gln Val  Val Leu Asp 
    1010                 1015                 1020             


Leu Ser  Phe Lys Leu Glu Lys  Met Ile Ile Glu Lys  Gly His Lys 
    1025                 1030                 1035             


Asp Arg  Ile Asn Gln Leu Cys  Thr Gly Ala Thr Gly  Glu Leu Leu 
    1040                 1045                 1050             


Thr Gly  Asn Ile Cys His His  Thr Tyr Leu Thr Trp  Leu Lys Asp 
    1055                 1060                 1065             


Lys Glu  Met Ile Asp Asn Glu  Thr Phe Ile Phe Met  Asn Met Val 
    1070                 1075                 1080             


Gln His  Cys Phe Ser His Asn  Gln Tyr Pro Gln Lys  Lys Thr Met 
    1085                 1090                 1095             


Glu Arg  Ile Ile Asn His Trp  Glu Pro Asp Arg Phe  Ala Leu Thr 
    1100                 1105                 1110             


Ile Ala  Ala Thr Tyr Asn Gln  Lys Ile Ala Gly Ile  Leu Glu Asp 
    1115                 1120                 1125             


Ile Gly  Thr Phe Pro Phe Ile  Arg Ser Arg Lys Thr  Met Pro Asp 
    1130                 1135                 1140             


Val Val  
    1145 


<210>  2436
<211>  1160
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2436

Met Lys Asn Glu Ile Leu Thr Asn Ser Lys Ser Leu Lys Ser Asn Pro 
1               5                   10                  15      


Asp Tyr Phe Ser Ala Tyr Leu Asn Met Ala Arg His Asn Ala Tyr Leu 
            20                  25                  30          


Ile Leu Ser His Ile Ser Asp Lys Leu Lys Pro Lys Lys Thr Asn Thr 
        35                  40                  45              


Pro Glu Asp Ala Leu His Ser Ala Tyr Ala Leu Glu Val Leu Lys Ser 
    50                  55                  60                  


Ser Lys Glu Pro Asp Ile Thr Ala Lys Ser Ile Lys Met Leu Asn Glu 
65                  70                  75                  80  


His Phe Pro Phe Leu Lys Val Met Phe Asp Thr Asn Ser Ile Thr Glu 
                85                  90                  95      


Lys Ser Lys Gly Ser Lys Gly Ile Tyr Ser Glu Lys Leu Pro Glu Gln 
            100                 105                 110         


Tyr Leu Asp Lys Met Met Leu Leu Leu Asp His Leu Asn Asn Tyr Arg 
        115                 120                 125             


Asn Ser Tyr Thr His Cys Val His Ile Pro Ile Ile Asn Asp Lys Asn 
    130                 135                 140                 


Phe Ile Tyr Cys Leu Asn Asn Ile Phe Asp Ala Ser Val Arg Thr Val 
145                 150                 155                 160 


Lys Asp Arg Phe Glu Phe Ser Glu Asn Asp Val Ser His Leu Arg Arg 
                165                 170                 175     


Tyr Glu Gln Val Phe Asp Pro Glu Thr Lys Lys Arg Lys Ala Ser Arg 
            180                 185                 190         


Lys Lys Asp Phe Lys Tyr Asn Phe Ile Asp Asn Asp Asp Ile Ser Glu 
        195                 200                 205             


Lys Gly Ile Ala Phe Phe Ile Ala Leu Phe Leu Glu Lys Lys His Ala 
    210                 215                 220                 


Phe Glu Phe Leu Lys Lys Leu Ser Asp Phe Lys Asp Ser Arg Thr Lys 
225                 230                 235                 240 


Met Met Gln Ala Thr Leu Glu Ser Tyr Cys Val Tyr His Ile Arg Leu 
                245                 250                 255     


Pro Lys Glu Arg Ile Glu Asn Thr Gln Asn Asp Leu Ser Leu Cys Leu 
            260                 265                 270         


Asp Ile Phe Asn Glu Leu Lys Lys Cys Pro Ser Glu Leu Phe Asp Leu 
        275                 280                 285             


Leu Lys Lys Glu Asp Ala Glu Lys Phe Arg Ile Lys Pro Asp Ile Asn 
    290                 295                 300                 


Asn Leu Asn Asp Glu Asp Ser Gly Asn Ile Val Glu Asn Ser Thr Asp 
305                 310                 315                 320 


Asp Tyr Asn Val Glu Pro Ile Leu Lys Arg Tyr Ser Asn Arg Phe Pro 
                325                 330                 335     


Tyr Leu Ala Met Arg Tyr Ile Asp Glu Lys Lys Val Phe Gln Lys Leu 
            340                 345                 350         


Arg Phe His Val Asp Leu Gly Asn Tyr Tyr Phe Lys Phe Tyr Pro Lys 
        355                 360                 365             


Thr Thr Val Asp Gly Glu Lys Arg Asp Arg Ser Leu Lys Val His Leu 
    370                 375                 380                 


Asn Ser Phe Gly Arg Leu Asp Asp Leu Asn His Ala Arg Leu Val Glu 
385                 390                 395                 400 


Trp Asn Asp Leu Ile Arg Phe His Lys Glu Glu Glu Asp Glu Asn Pro 
                405                 410                 415     


Ile Glu Glu Leu Met Pro Tyr Ile Thr Asp Thr Tyr Pro His Tyr His 
            420                 425                 430         


Leu His Asn Asn Gln Ile Gly Leu Lys Asp Thr Gln Asn Asn Pro Asp 
        435                 440                 445             


Lys Leu Leu Pro Lys Ile Glu Arg Glu Lys Thr Lys Thr Glu Gln Pro 
    450                 455                 460                 


Asp Phe Trp Leu Ser Thr Tyr Glu Leu Pro Ala Leu Leu Phe Tyr Ser 
465                 470                 475                 480 


Tyr Leu Leu Lys Lys Lys Arg Asp Ile Ser Ala Glu Asp Leu Ile Leu 
                485                 490                 495     


Asn Cys Arg Lys Lys Tyr His Thr Leu Phe Lys Leu Ile Ser Glu Gly 
            500                 505                 510         


Asn Gly Pro Glu Ile Lys Glu Cys Gln Val Thr Ile Lys Gln Lys Gly 
        515                 520                 525             


Lys Asn Ile Ser Val Phe Leu Leu Thr Ala His Phe Glu Asp Glu Thr 
    530                 535                 540                 


Gly Lys Ser His Glu Ile Glu Leu Asn Asp Leu Pro Gln Val Phe Gln 
545                 550                 555                 560 


Asn Tyr Leu Thr Asp Lys Gln Leu His Asn Arg Glu Glu Leu Ala Glu 
                565                 570                 575     


Asn Lys Ile Asn Arg Leu Ile Ile Glu Thr Glu Arg Arg Arg Glu Lys 
            580                 585                 590         


Ile Asn Lys Asp Leu Glu Arg Ile Asn Gly Leu Lys Gly Asn Lys Arg 
        595                 600                 605             


Gly Lys Lys Asn Phe Val Glu Ile Lys Ser Gly Met Leu Ala Asp Phe 
    610                 615                 620                 


Leu Ala Lys Asp Thr Ile Arg Leu Gln Pro Ser Ile Asp Ala Ile Gly 
625                 630                 635                 640 


Lys Asp Lys Ile Thr Gly Leu Asn Phe Gln Ile Leu Gln Ser His Leu 
                645                 650                 655     


Ala Phe Tyr Gly Arg Asp Phe Leu Met Leu Lys Asp Ile Phe Arg Gln 
            660                 665                 670         


Cys Lys Leu Val Asp Ala Gln Ile Ser His Pro Phe Leu Tyr Lys Leu 
        675                 680                 685             


Asn Pro Glu Asp His Phe Asp Ile Val Ser Phe Tyr Lys Ala Tyr Leu 
    690                 695                 700                 


Gly Glu Arg Lys Lys Tyr Leu Glu Gln Cys Asn Arg Asn Lys Asp Tyr 
705                 710                 715                 720 


Lys Ser Tyr Tyr Phe Leu Lys Phe Asn Ser Gln Lys Phe Thr Thr Glu 
                725                 730                 735     


Thr Ile Glu Tyr Cys Lys Asp Leu Ala Lys Lys Leu Met Asn Thr His 
            740                 745                 750         


Ser Gln Asp Asn His Pro Ile Asn Leu Pro Arg Gly Met Phe Met Asp 
        755                 760                 765             


Ala Ile Ile Asp Trp Phe Lys Lys His Gly Asp Pro Gln Leu Gln Ala 
    770                 775                 780                 


Ile Ala Lys Thr Glu Arg Val Asn Ala Val Tyr Leu Ile Gln Lys Phe 
785                 790                 795                 800 


Phe Glu Phe Lys Lys Asp Ser Asn Gln Pro Phe Tyr Asp Tyr Pro Arg 
                805                 810                 815     


Ser Tyr Asp Phe Ile Asp Lys Leu Glu Asn Phe Asn Asn Met Arg Cys 
            820                 825                 830         


Gly Arg Pro Leu Leu Leu Gln Arg Lys Tyr Tyr Ser Ile Gln Gln Leu 
        835                 840                 845             


Ala Asp Lys Ile Asp Asp Val Lys Thr Arg Ile Thr Lys Leu Pro Glu 
    850                 855                 860                 


Ser Glu Pro Asn Asp Ser His Pro Arg Lys Arg Met Leu Ala Thr Leu 
865                 870                 875                 880 


Ser Asp Tyr Lys Gln Asn Glu Lys Leu Leu Arg Leu Tyr Lys Thr Gln 
                885                 890                 895     


Asp Arg Ile Leu Phe Leu Val Ala Ser Asp Ile Leu Phe Ala Gln Lys 
            900                 905                 910         


Pro Gln Gly Leu Glu Glu Asn Asp Leu Lys Leu Ser Asn Val Lys Pro 
        915                 920                 925             


Lys Pro Glu Asn Asp Ser Asp Glu Asp Leu Leu Ser Ser Gln Leu Pro 
    930                 935                 940                 


Phe Arg Phe Pro Tyr Gln Tyr Trp Asp Val Thr Ser Lys Gly Glu Ile 
945                 950                 955                 960 


Asp His Lys Asn Lys Ile Gly Glu Val Ile Ile Phe Gln Lys Lys Leu 
                965                 970                 975     


Lys Leu Lys Asn Tyr Gly Asp Phe Ile Arg Tyr Thr Lys Asp Arg Arg 
            980                 985                 990         


Leu Asn Asn Leu Phe His Trp Thr  Gly Asp Ile Glu Leu  Glu Met Pro 
        995                 1000                 1005             


Val Leu  Gln Lys Glu Leu Glu  Arg Tyr Glu Glu Ala  Arg Leu Thr 
    1010                 1015                 1020             


Val Phe  Arg Leu Ile His Asp  Phe Glu Lys Ala Met  Tyr Glu Lys 
    1025                 1030                 1035             


His His  Leu Phe Phe Asp Glu  Leu Leu Lys Thr Asn  Lys Leu Lys 
    1040                 1045                 1050             


Lys Glu  Asn Glu Asn Glu Asn  Ser Tyr Ile Asn His  Glu Glu Met 
    1055                 1060                 1065             


Leu Glu  Lys Phe Phe Ser Asp  Tyr Pro Glu Leu Ile  His Tyr Glu 
    1070                 1075                 1080             


Asp Val  Met Leu Thr Ile Arg  Asn Cys Phe Ser His  Asn Gln Tyr 
    1085                 1090                 1095             


Pro Val  Lys Cys Ala Phe Asp  Asn Ile Asp Ser Ile  Gly Leu Phe 
    1100                 1105                 1110             


Glu Gly  Cys Pro Asp Ile Glu  Ser Asp His Asp Asn  Glu Leu Asn 
    1115                 1120                 1125             


Ile Ala  Met Arg Ile Lys Asn  His Ala Ile Ala Thr  Tyr Gly Glu 
    1130                 1135                 1140             


Phe Ile  Lys Ile Leu Thr Asn  Leu Thr Pro Ile His  Asp Ile Asn 
    1145                 1150                 1155             


Val Ser  
    1160 


<210>  2437
<211>  1082
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2437

Met Asp Lys Pro Lys Tyr His Pro Lys Ala Ala Phe Ala Leu Phe Leu 
1               5                   10                  15      


Asn Gln Ala Glu His Asn Ile Val Lys Ala Leu Asn His Ile Thr Gly 
            20                  25                  30          


Lys Glu Ile Lys Glu Lys Gly Asn Gly Ser Ile Glu Asn Ile Ile Lys 
        35                  40                  45              


Glu Met Lys Thr Glu Glu Phe Tyr Trp Leu Glu Asn Asn Tyr Phe Lys 
    50                  55                  60                  


Phe Leu Arg Ile Asp Asp Asn Ser Ala Ile Phe Glu Leu Glu Thr Ile 
65                  70                  75                  80  


Asn Ile Glu Lys Glu Glu Asp Lys Lys Asn Lys Arg Leu Glu Ile Lys 
                85                  90                  95      


Lys Asn Ile Phe Leu Tyr Thr Tyr Leu Arg Leu Lys Asp Leu Arg Asn 
            100                 105                 110         


Phe Tyr Ser His Phe Tyr His Lys Asn Phe Lys Thr Leu Lys Ile Asn 
        115                 120                 125             


Glu Glu Asn Gln Gln Ile Asn Ile Phe Glu Ile Lys Glu Gly Thr Lys 
    130                 135                 140                 


Glu Asp Glu Tyr Leu Arg Lys Phe Leu Lys Ile Arg Phe Lys Glu Ala 
145                 150                 155                 160 


Lys Glu Phe Tyr Ser Asn Phe Ile His Gln Thr Pro Asn Gly Phe Glu 
                165                 170                 175     


His Lys Tyr Lys Pro Glu His Leu Glu His Leu Asp Leu Glu Asp His 
            180                 185                 190         


Lys Lys Glu Thr Tyr Lys His Tyr Gln Phe Phe Asn Tyr Asn Lys Asp 
        195                 200                 205             


Asn Lys Ser Tyr Tyr Phe Asp Asn Gly Glu Lys Lys His Lys Lys Arg 
    210                 215                 220                 


Asn Tyr Lys Ser Thr Val Phe Leu Thr Ser Phe Phe Leu Asp Lys Gln 
225                 230                 235                 240 


His Ile Asn Met Phe Leu Asp Gln Val Lys Gly Phe Lys Arg Ser Ser 
                245                 250                 255     


Asp Lys Glu Ala Gln Ala Thr Arg Glu Val Phe Thr Arg Phe Cys Met 
            260                 265                 270         


Thr Thr Asp Ser Ser Phe Lys Ser Glu Asn Thr Tyr Val Arg Phe Phe 
        275                 280                 285             


Val Asp Ala Phe Thr His Leu Ser Lys Val Pro Arg Leu Ala Leu Asp 
    290                 295                 300                 


Asn Tyr Lys Thr Glu Asp Leu Gln Ile Lys Ile Ser Tyr Asp Ser Leu 
305                 310                 315                 320 


Lys Lys Thr Lys Glu Val Ile Phe Gln Gln Glu Lys Pro Asp Thr Lys 
                325                 330                 335     


Tyr Glu Ile Thr Asp Lys Lys Tyr Leu Ile Ala Leu Glu Leu Gln Asn 
            340                 345                 350         


Ile Phe Asp Lys Leu Asn Val Ile Glu Asn Asn Glu Phe Asn Ser Val 
        355                 360                 365             


Ser Glu Leu Lys Asn Lys Ile Asp Glu Leu Ile Lys Lys Glu Ile Glu 
    370                 375                 380                 


Lys Ile Ile Gly Thr Lys Lys Tyr Glu Asn Tyr Lys Asp Ile Leu Ile 
385                 390                 395                 400 


Asn Phe Ala Leu Thr Asn Glu Gln Ile Arg Thr Ser Arg Asp Arg Phe 
                405                 410                 415     


Thr Glu Phe Ala Leu Gln Phe Ile Asp Asp Phe Lys Leu Phe Asp Lys 
            420                 425                 430         


Ile Arg Phe Lys Ile Tyr Ser Gly Arg Val Phe Glu Ile Leu His His 
        435                 440                 445             


Lys Thr Tyr His Ser Lys Thr Ile Phe Glu Arg Asn Tyr Ile Arg Ser 
    450                 455                 460                 


Glu Lys Ile Tyr Ser Arg Ile Asn Glu Ile Glu Lys Thr Gln Ile Lys 
465                 470                 475                 480 


Lys Glu Asp Leu Asp Leu Glu Pro Tyr Tyr Ile Asn Thr Lys Ser Lys 
                485                 490                 495     


Glu Val Lys Asn Val Glu Ile Phe Asp Asn Ala Gln Glu Pro Lys Tyr 
            500                 505                 510         


Phe Ile Arg Asn Asn Asn Ile Phe Phe Glu Val Lys Met Phe Asp Gly 
        515                 520                 525             


Ser Gln Gln Lys Ala Ser Met Ser Val Asn Glu Leu Arg Asn Leu Ile 
    530                 535                 540                 


Phe Ala Leu Asp Asp Glu Gln Gln Val Glu Asn Arg Ile Ile Gly Tyr 
545                 550                 555                 560 


Leu Thr Lys Tyr Arg Lys Leu Leu Thr Glu Ile Leu Ser Gly Lys Asn 
                565                 570                 575     


Pro Ser Glu Ile Lys Val Asn Ile Pro Glu Ala Glu Leu Pro Lys Tyr 
            580                 585                 590         


Ile Val Lys Tyr Leu Lys Ser Glu Ser Ser Asn Ile Asp Asn Tyr Lys 
        595                 600                 605             


Lys Asp Val Leu Asn Lys Leu Glu Tyr Leu Asn Asn Gln Asn Lys Lys 
    610                 615                 620                 


Ser Ile Leu Asn Leu Ser Lys Ile Arg Lys Tyr Glu Lys Val Arg Glu 
625                 630                 635                 640 


Ile Thr Arg Phe Phe Asn Asn Tyr Ile Pro Lys Tyr Ile Asp Gln Asn 
                645                 650                 655     


Gln His Gln Glu Leu Glu Lys Leu Leu Gly Asn Tyr Pro Lys Ser Lys 
            660                 665                 670         


Asn Asn Ile Ala Asn Phe Ile Lys Glu Gln Asn Leu Asn Lys Gly Trp 
        675                 680                 685             


Lys Gln Asn Leu Leu Asn Ile Asn Thr Met Phe Ser Tyr Lys Ser Asn 
    690                 695                 700                 


Tyr Asn Ser Leu Asp Asp Ile Leu Asn Asp Ile Tyr Asn Lys Asn Ile 
705                 710                 715                 720 


Glu Trp Cys Lys Gln Lys Thr Asn Lys Ile Asn Lys Thr Asn Glu Ile 
                725                 730                 735     


Asp Lys Ser Tyr Leu Asp Lys Val Ala Lys Ile Ile Asn Val Thr Glu 
            740                 745                 750         


Arg Asn Tyr Ser Phe Asp Arg Ile Lys Gln Asn Ile Glu Thr Phe Leu 
        755                 760                 765             


Asn Glu Asn Ile Val Ile Pro Arg Gly Phe Ile Arg Lys Tyr Ile Tyr 
    770                 775                 780                 


Asn Asn Ile Asn Leu Ser Glu Lys Ile Asn Lys Lys Val Glu Asn Glu 
785                 790                 795                 800 


Leu Ala Cys Val Tyr Cys Asn Lys Val Lys Asp Leu Tyr Thr Glu Ala 
                805                 810                 815     


Gln Ser Ala Thr Asn Ser Lys Arg Glu Lys Tyr Ile Gln Ala Lys Lys 
            820                 825                 830         


Leu Asn Glu Gln Ile Ile Lys Asp Lys Val Leu Phe Leu Met Ala Lys 
        835                 840                 845             


Lys Tyr Leu Glu Lys Lys Ile Thr Gly Thr Gly Lys Lys Ser Glu Leu 
    850                 855                 860                 


Lys Val Thr Asn Glu Ile Gly Glu Ile Leu Lys Glu Gly Ile Glu Ile 
865                 870                 875                 880 


Glu Lys Phe Asp Lys Lys Ile Lys Phe Gly Ile Asn Glu Phe Asp Arg 
                885                 890                 895     


Ile His Thr Val Leu Asn Asp Lys Arg Leu Lys Asn Ile Leu Lys Asn 
            900                 905                 910         


Tyr Leu Pro His Leu Glu Glu Ile Tyr Tyr Val Asp Arg Lys Lys Tyr 
        915                 920                 925             


Asp Glu Lys Asn Leu Val Thr Glu Lys Leu Trp Asp Leu Gln Asp Val 
    930                 935                 940                 


Tyr Lys Thr Ile Asp Glu Gln Gln Leu Lys Leu Leu Asp Ala Ile Leu 
945                 950                 955                 960 


Gln Lys Glu Glu Asp Ile Leu Phe Glu Tyr Leu Ser Lys Gln Ala Glu 
                965                 970                 975     


Lys Val Glu Ile Leu Pro Arg Tyr Val Glu Arg His Ile Asn Arg Thr 
            980                 985                 990         


Thr Ile Asp Glu Val Leu Asn Lys  Glu Glu Phe Asn Lys  Tyr Ile Asn 
        995                 1000                 1005             


Lys Tyr  Arg Asp Ile Leu Asn  Asp Leu Ile Ser Asp  Leu Leu Thr 
    1010                 1015                 1020             


Glu Glu  Asn Arg Ile Lys Thr  Glu Asp Ile Phe Ala  Lys Ala Ser 
    1025                 1030                 1035             


Ile Pro  Phe Asp Glu Lys Ile  Glu Gly His Gln Tyr  Ser Ile Arg 
    1040                 1045                 1050             


His Tyr  Arg Asn Ala Ala Phe  His Asn Gly Leu Pro  Glu Ser Gly 
    1055                 1060                 1065             


Thr Phe  Glu Asp Gly Ile Asn  Leu Leu Asp Gln His  Ile Asn 
    1070                 1075                 1080         


<210>  2438
<211>  1159
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2438

Met Lys Lys Glu Arg Lys Ser Ile Met Glu Arg Asn His Asp Ile His 
1               5                   10                  15      


Val Asn Ile Val Ala Asp Lys Pro Phe Ile Ala Gly Tyr Phe Asn Leu 
            20                  25                  30          


Ala Thr Asn His Leu Glu Glu Leu Arg Ile Ala Ile Gln Ala Arg Phe 
        35                  40                  45              


Pro Asn Leu Lys Asn Ala Arg Asn Phe Leu Ser Leu Thr Ser Val Asn 
    50                  55                  60                  


Thr Asp Gln Asn Glu Asp Gln Cys Ile Gln Lys Lys Ile Ser Glu Met 
65                  70                  75                  80  


Ser Glu Ser Asp Tyr Gln Thr Leu Leu Asp Phe Val Ser Ser Tyr Phe 
                85                  90                  95      


Arg Ala Val Ser Leu Val Lys Gln Ser Ser Phe Val Asn Lys Val Leu 
            100                 105                 110         


Asp Arg Ile Trp Leu Trp Lys Arg Ile Asn Ser Ile Leu Ile Leu Gln 
        115                 120                 125             


Asn Ser Leu Arg Asp Tyr Tyr Ile His Tyr Cys His Pro Glu Val Ile 
    130                 135                 140                 


Ile Ser Asp Pro Asp Phe Lys Asn Leu Leu Glu Gln Met Phe Ile Tyr 
145                 150                 155                 160 


Ser Ala Leu Asp Val Lys Lys Lys Arg Leu Lys Gly Glu Gln Ala Leu 
                165                 170                 175     


Arg Val Ile Lys Ser Ser Phe Lys Asp Glu Leu Lys Lys Leu Glu Ile 
            180                 185                 190         


Asp Gln Lys Lys His Leu Thr Glu Lys Thr Lys Val Asn Pro Lys Ile 
        195                 200                 205             


Ser Leu Asp Asp Asp Ser Val Arg Asn Ala Thr Leu Asn His Leu Ile 
    210                 215                 220                 


Tyr Arg Met Val Lys Lys Asn Lys Asn Thr Gly Glu Tyr Asp Ala Ile 
225                 230                 235                 240 


Asn Asp Lys Tyr Gln Leu Phe Lys Leu Val Glu Gly Ser Thr Asp Gln 
                245                 250                 255     


Trp Arg Phe Thr Asp Asp Gly Leu Ala Phe Phe Leu Gly Leu Phe Leu 
            260                 265                 270         


Thr Lys Lys Glu Gly Leu Glu Phe Arg Ser Gln Ile Arg Gly Phe Lys 
        275                 280                 285             


Asp Asn Asn Asn Leu Ser His Asn Val Thr Gln Trp Val Phe Ser Tyr 
    290                 295                 300                 


Pro Ala Phe Arg Arg Ala Asp Arg Asn Phe Thr Thr Val Phe Ser Lys 
305                 310                 315                 320 


Asp Ala Phe Ile Phe Gln Met Ile Asp Glu Leu Asn Lys Val Pro Asp 
                325                 330                 335     


Glu Val Tyr Arg Asn Leu Ser Gln Glu Lys Gln Asp Glu Phe Leu Val 
            340                 345                 350         


Asp Ile Asn Ser Tyr Phe Lys Asp Lys Thr Asp Ala Pro Gly Ser Thr 
        355                 360                 365             


Pro Glu Gln Glu Thr Val Val Asn Leu Val Ile Arg Lys Arg Tyr Glu 
    370                 375                 380                 


Asp Lys Phe Glu Tyr Phe Ala Leu Arg Tyr Leu Asp Glu Phe Ala Gly 
385                 390                 395                 400 


Phe Thr Arg Ile Arg Phe Gln Val Tyr Val Gly Asp Tyr Ile His Asp 
                405                 410                 415     


Arg Arg Glu Lys Glu Ile Gly Asn Ser Asn Leu Tyr Thr Glu Arg Glu 
            420                 425                 430         


Cys Arg Glu Lys Val Lys Thr Phe Gly Asn Leu Thr Glu Leu Gln Lys 
        435                 440                 445             


Gly Lys Thr Glu Tyr Phe Glu Gly Lys Ala Val Pro Glu Ile Pro Gly 
    450                 455                 460                 


Trp Arg Arg Phe Pro Asn Pro Ser Tyr Arg Ile Glu Asn His Asn Ile 
465                 470                 475                 480 


Leu Leu Ser Leu Ser Ile Lys Asn Glu Lys Ile Lys Asp Arg Ile Gln 
                485                 490                 495     


Lys Ala Gln Lys Ala Leu Gly Ser Ala Gly Asp Lys Glu Arg Ser Ser 
            500                 505                 510         


Arg Thr Glu Lys Pro Val Arg Trp Glu Met Leu Asn Glu Met Tyr Thr 
        515                 520                 525             


Lys Gly Pro Tyr Lys Phe Asn Ser Thr Pro Phe Ile Thr Gln Met Ser 
    530                 535                 540                 


Leu Asn Glu Leu Pro Ala Leu Leu Tyr Ala Leu Leu Ile Asp Gln Lys 
545                 550                 555                 560 


Arg Pro Glu Asp Ile Glu Asp Gln Ile Ile Gln Thr Tyr Gln Glu His 
                565                 570                 575     


Phe His Glu Ile Glu Lys Gly Glu Gly Lys His Leu Pro Lys Ser Leu 
            580                 585                 590         


Pro Gln Ser Asn Lys Glu Gly Ala Asp Met Gly Lys Leu Gln Lys Asp 
        595                 600                 605             


Ile Gln Lys Val Ile Asp Asp Ser Asp Glu Arg Leu Leu Ser Phe Asp 
    610                 615                 620                 


Lys Leu Lys Arg Glu Lys Ser Lys Gly Arg Asn Ser Arg Pro Leu Tyr 
625                 630                 635                 640 


His Val Phe Asp Ser Lys Thr Met Gly Glu Thr Val Ser Phe Leu Ala 
                645                 650                 655     


Lys Asp Ile Leu Arg Phe Met Pro Val Thr Tyr Arg Glu Asn Trp Lys 
            660                 665                 670         


Gly Tyr Met His Ser Glu Trp Gln Ala Leu Leu Ser His Tyr Glu Val 
        675                 680                 685             


Asp Arg Gln Ala Ala Ile Asp Leu Leu Phe Ser Cys Trp Lys Ile Gln 
    690                 695                 700                 


Asn Asp Leu Lys Ser Ile Gly Met Glu Ile Arg Asn Leu Phe Gln Lys 
705                 710                 715                 720 


Ser Glu Thr Phe Glu Glu Leu Tyr Glu Glu Tyr Leu Lys Phe Arg Lys 
                725                 730                 735     


Gln Tyr Met Arg Leu Leu Leu Val Gly Leu Gly Ser Ala Asp Ile Gln 
            740                 745                 750         


Thr Phe Phe Thr Glu Lys Gly Val Trp Asn Tyr Phe His Lys Arg Leu 
        755                 760                 765             


Tyr Val Arg Asp Pro Thr Ala Thr Leu Thr Asp Arg Leu Leu Ala Arg 
    770                 775                 780                 


Pro Ile Val Leu Pro Arg Gly Ile Phe Asp Lys Lys Pro Thr Tyr Ile 
785                 790                 795                 800 


Lys Gly Lys Asp Pro Glu Thr Asn Arg Glu Asp Phe Ala Asp Trp Tyr 
                805                 810                 815     


Val Tyr Pro Tyr Glu Arg Glu Cys Gly Val Gln Met Phe Tyr Gly Tyr 
            820                 825                 830         


Gly Leu Asp Thr Asp Leu Gly Phe Glu Asp Tyr Arg Ile Phe Ser Glu 
        835                 840                 845             


Ser Ile Arg Asp Asn Arg Tyr Asp Trp Ser Glu Glu His Gln Lys Glu 
    850                 855                 860                 


Leu Phe Arg Lys Lys Glu Leu Ser Arg Val Lys Asn Val Lys Arg Lys 
865                 870                 875                 880 


Asp Ala Phe Leu Tyr Leu Met Val Lys Lys Met Leu Glu Asp Glu Glu 
                885                 890                 895     


Val Pro Phe Lys Leu Ser Leu Asn Asp Phe Tyr Leu Pro Gln Asp Asp 
            900                 905                 910         


Ile Ser Lys Arg Lys Gly Val Ala Leu Gly Gln Lys Asn Arg Gln Pro 
        915                 920                 925             


Gly Asp Lys Ser Glu Asn Ile Arg Lys Glu Thr Tyr Ile Trp Asn Met 
    930                 935                 940                 


Thr Leu Pro Phe Tyr Tyr Glu Arg Glu Asp Glu Asn Glu Glu Lys His 
945                 950                 955                 960 


Lys Val Phe Ser Glu Glu Lys Val Gln Val Lys Asp Leu Arg Thr Leu 
                965                 970                 975     


Ala Ala Arg Met Thr Asp Ser Lys Val Gln Cys Leu Phe Asp Tyr Asp 
            980                 985                 990         


Pro Ser His Leu Trp Asn Arg Lys  Ser Leu Glu Ser Glu  Leu Ser Asn 
        995                 1000                 1005             


Tyr Glu  Lys Ile Arg Arg Glu  Asn Leu Leu Val Ile  Ile Gln Gly 
    1010                 1015                 1020             


Phe Glu  Arg Glu Val Leu Leu  Arg Tyr Gly Trp Lys  Glu Gly Glu 
    1025                 1030                 1035             


Val Ala  Pro Asp Asp Leu Leu  Lys Thr Asp Lys Lys  Gly Lys Lys 
    1040                 1045                 1050             


Phe Pro  Asn Phe Lys Arg Tyr  Val Phe Ser Ser Pro  Leu Gly Phe 
    1055                 1060                 1065             


Ser Lys  Glu Thr Ile Pro Gln  Leu Leu Asp Asn Ser  Trp Pro Gln 
    1070                 1075                 1080             


Phe Lys  Lys Asn Tyr Pro Gln  Ser Ala Ala Phe Pro  Lys Val Ser 
    1085                 1090                 1095             


Gln Gly  Tyr Gln Leu Ile Gln  Ile Arg Asn Lys Phe  Ala His Asn 
    1100                 1105                 1110             


Lys Leu  Pro Asp Val Ser Phe  Phe Arg Glu Cys Thr  Ala Phe Leu 
    1115                 1120                 1125             


Ala Lys  Asp Pro Ser Glu Tyr  Tyr Ser Gln Tyr Tyr  Phe Arg Leu 
    1130                 1135                 1140             


Ala Glu  Lys Ile Ile Asn Ser  Leu Glu Asn Asn Ile  His Ser Asp 
    1145                 1150                 1155             


Ala 
    


<210>  2439
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2439

Met Gly Val Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Gly Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Val Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asp Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Phe Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2440
<211>  1087
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2440

Met Glu Ala Lys His Glu Thr Gln Tyr Phe Asp Phe Thr Asn Lys Glu 
1               5                   10                  15      


His Lys His Phe Phe Ala Gly Leu Phe Asn Thr Ala Gln His His Phe 
            20                  25                  30          


Asp Leu Ser Leu Thr Glu Leu Ala Asp Arg Ile Asn Glu Lys Gly Lys 
        35                  40                  45              


Thr Gly Lys Gly Phe Ile Lys Glu Ala Phe Ser Asp Ala Ile Ser Glu 
    50                  55                  60                  


Ala Asp Trp Glu Thr Arg Ile Asn Tyr Leu Ser Glu Ser Leu Thr Phe 
65                  70                  75                  80  


Ile Asn Tyr Phe Asp Tyr Asp Cys Arg Thr Ala Phe Arg Glu Ile Met 
                85                  90                  95      


Leu Leu Leu Tyr Asp Thr Ile Thr Asn Tyr Arg Asn Tyr Tyr Ser His 
            100                 105                 110         


Tyr Gln His Lys Lys Val Ala Leu Asp Asp Ala Ile Phe Pro Phe Leu 
        115                 120                 125             


Asp Glu Leu Leu Phe Lys Ser Ala Leu Asn Val Lys Arg Asn Arg Ala 
    130                 135                 140                 


Lys Ser Glu Ile Tyr Lys Ala His Leu Ser Val Lys Tyr Lys Ser Glu 
145                 150                 155                 160 


Phe Asp Lys Ile Ile Ala Lys Ser Asn Glu Lys Ile Glu Ala Tyr Asn 
                165                 170                 175     


Ala Gln Leu Lys Lys Gly Glu Lys Lys Arg Ala Phe Ile Lys Gln Lys 
            180                 185                 190         


Asp Glu Val Asn His Val Leu Asn Gln Val Phe Arg Ser Phe Leu Tyr 
        195                 200                 205             


Lys Asn Asp Asn Gly Glu Glu Thr Leu Ser Glu Tyr Ala Leu Ser Lys 
    210                 215                 220                 


Thr Asp Glu Gly His Leu Ser Thr Tyr Gly Phe Val Gln Leu Ala Ala 
225                 230                 235                 240 


Leu Phe Leu Ser Lys Lys Gln Thr Glu Ser Leu Leu Asn Tyr Thr Lys 
                245                 250                 255     


Tyr Leu Lys Asp Thr Arg Glu Leu Arg Phe Val Ser Ser Arg Trp Thr 
            260                 265                 270         


Phe Thr Phe Leu Cys Tyr Arg Asp Ile Lys Arg Leu Phe Arg Ser Asp 
        275                 280                 285             


Tyr Ser Asn Asp Ser Leu Leu Leu Gln Met Ile Ser Glu Leu Asn Lys 
    290                 295                 300                 


Cys Pro Asp Ala Leu Tyr Gln His Leu Ser Pro Glu Lys Lys Gln Glu 
305                 310                 315                 320 


Phe Leu Glu Asp Ile Asn Thr Tyr Tyr Lys Asp Asn Ser Glu Phe Phe 
                325                 330                 335     


Gly Thr Gln Glu Lys Ala Leu Val Ser His Glu Val Leu Gln Lys Arg 
            340                 345                 350         


Tyr Ser Asn Lys Phe Ala Tyr Phe Ala Leu Arg Phe Leu Asp Glu Val 
        355                 360                 365             


Cys Asn Phe Pro Thr Leu Arg Phe Ser Ile Asn Leu Gly Lys Phe Asn 
    370                 375                 380                 


His Asp Thr Ser Pro Lys Thr Phe Asn Ser Lys Val Ile Thr Glu Arg 
385                 390                 395                 400 


Ser Leu Leu Glu Lys Ile Thr Val Phe Thr Lys Leu Ser Glu Ala Thr 
                405                 410                 415     


Asp Ala Lys Lys Ala Tyr Phe Lys Asn Pro Glu Asn Ile Asp Leu Val 
            420                 425                 430         


His Asp Trp Leu Glu Phe Pro Met Pro Ser Tyr Gln Phe Asn Arg Asn 
        435                 440                 445             


Asn Ile Gly Ile Trp Leu Ala Ile Asn Asp Asp Ser Gly Lys Ser Asp 
    450                 455                 460                 


Ala Ala Thr Lys Arg Asn Arg Glu Asp Lys Lys Thr Lys Tyr Ala Ile 
465                 470                 475                 480 


Ala Glu Lys Leu Gly Leu Thr Asp Thr Val Lys Lys Pro Ile Ala Phe 
                485                 490                 495     


Leu Ser Ser Asn Glu Leu Pro Ala Leu Leu Tyr Ala Leu Leu Ile Glu 
            500                 505                 510         


Asn Lys Thr Pro Asn Asp Val Glu Ser Leu Leu Arg Lys Lys Ile Gln 
        515                 520                 525             


Ile Gln Arg Gly Leu Leu Asp Lys Phe Gly Lys Arg Glu Leu Val Asn 
    530                 535                 540                 


Arg Lys Val Phe Pro Lys Lys Leu Leu Gln Ser Arg Asp Lys Leu Thr 
545                 550                 555                 560 


Phe Asp Ile Glu Lys Leu Lys Gln Asn Ile Thr Thr Glu Ile Lys Lys 
                565                 570                 575     


Asn Pro Leu Lys Asp Ile Arg Lys Lys Tyr Lys Lys Lys Pro Lys Glu 
            580                 585                 590         


Pro Asn Glu Leu Thr Asn Lys Glu Lys Gly Asn Ile Ala Thr Trp Leu 
        595                 600                 605             


Ala Asp Asp Ile Lys Arg Phe Thr Ser Lys Ala Thr Lys Lys Asp Trp 
    610                 615                 620                 


Lys Gly Tyr Gln Tyr Ala Glu Phe Gln Ala Leu Leu Ser Phe Tyr Asp 
625                 630                 635                 640 


Ile Asp Lys Glu Lys Pro Lys Ser Phe Leu Glu Gln Asp Leu His Tyr 
                645                 650                 655     


His Phe Lys Ile Asp Asn Pro Phe Gly Gly Val Asn Phe Asn His Lys 
            660                 665                 670         


Ser Leu Tyr Thr Phe Tyr Asn Thr Tyr Leu Lys Lys Arg Glu Lys Tyr 
        675                 680                 685             


Leu Glu Asp Leu Thr Lys Thr Ile Asp Ala Asn Tyr Gly Asp Ile Pro 
    690                 695                 700                 


Glu Thr Val Phe Ile Gly Phe Thr Lys Arg Ile Tyr Glu Ile Lys Pro 
705                 710                 715                 720 


Val Glu Ile Gln Lys Asp Thr Leu Leu Asn Lys Ile Pro Ile Asn Leu 
                725                 730                 735     


Pro Arg Gly Ile Phe Asp Asp Lys Pro Thr Ser Tyr Asp Lys Lys Glu 
            740                 745                 750         


Lys Pro Val Ala Leu Ala Gly Trp Phe Glu Lys Ser Asn Gln Leu Glu 
        755                 760                 765             


Asn Ala Gln Arg Phe Tyr His Phe Glu Lys Val Tyr Glu Tyr Pro Ile 
    770                 775                 780                 


Thr Val Leu Lys Trp Asn Pro Lys Lys Arg Lys Lys Glu Glu Lys Ile 
785                 790                 795                 800 


Val Leu Lys Glu Gln Ser Ile Asn Pro Asn Lys Gly Leu Lys Glu Gln 
                805                 810                 815     


Tyr Tyr Glu Asn Leu Pro Val Lys Asn Gln Arg Glu Ile Tyr Asn Asn 
            820                 825                 830         


Glu Lys Arg Ile Arg Lys Ile Met Arg Gln Asp Phe Phe Val Leu Glu 
        835                 840                 845             


Met Ala Lys His Leu Leu Gln Lys Ala Lys Val Lys Gly Leu Asp Asp 
    850                 855                 860                 


Leu Gln Leu Lys Asp Ile Phe Leu Thr Lys Lys Glu Lys Asn Lys Ile 
865                 870                 875                 880 


Gln Glu Glu Ser Lys Lys Gln Ser Glu Arg Asn Thr Gly Asp Thr Ser 
                885                 890                 895     


Lys Asn Ser Ile Thr Asp Ser His Ile Leu Ser Arg Lys Ile Glu Ile 
            900                 905                 910         


Ser Ile Leu Asp Gly Arg Val Lys Gly Thr Pro Lys Ile Lys Asp Val 
        915                 920                 925             


Gly Lys Cys Arg Lys Phe Glu Thr Asp Ala Arg Val Lys Glu Leu Val 
    930                 935                 940                 


Asn Tyr Phe Cys Asp Lys Thr Trp Ser Phe Thr Glu Ile Gln Asn Glu 
945                 950                 955                 960 


Ile Asp Asp Phe Asp Arg Val Arg Lys Phe Glu Leu Phe Lys Ser Val 
                965                 970                 975     


His Gln Leu Glu Lys Lys Ile Tyr Glu Asp Ala Thr Lys Lys Asn Cys 
            980                 985                 990         


Thr Asp Ala Leu Leu Asn Gln Gly  Asn Pro Ser Phe Lys  Arg Tyr Val 
        995                 1000                 1005             


Ser His  Tyr Phe Leu Glu Thr  Asp Lys Glu Ala Phe  Asn Asn Leu 
    1010                 1015                 1020             


Pro Ile  Lys Ile Ile Ser Ala  Thr Pro Glu Trp Gln  Lys Phe Phe 
    1025                 1030                 1035             


Leu Leu  Ala Lys Ile Arg Asn  Lys Phe Ser His Asn  Gln Phe Leu 
    1040                 1045                 1050             


Pro Thr  Glu Asp Phe Lys Lys  Leu Met Glu Phe Val  Pro Leu Glu 
    1055                 1060                 1065             


Lys Asp  Glu Leu Ile Ala Thr  Tyr Leu Asn Arg Ala  Phe Ile Glu 
    1070                 1075                 1080             


Leu Gln  Lys Arg 
    1085         


<210>  2441
<211>  1119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2441

Met Thr Glu Gln Asn Glu Lys Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Thr His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn His Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Cys Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Glu Lys Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Thr Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Ile Asp Ile Leu Ser Asp Glu Glu Asp Thr Asp Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Phe Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Asn Tyr Ser Asp Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Gly Glu Ile Asp Thr Leu Asp 
    530                 535                 540                 


Arg Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Gly Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Tyr Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Asp Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Leu Ala Lys Leu Lys Lys Glu Ile Leu Glu Ala 
        835                 840                 845             


Lys Glu His Pro Tyr Leu Asp Phe Lys Ser Trp Gln Lys Phe Glu Arg 
    850                 855                 860                 


Glu Leu Arg Leu Val Lys Asn Gln Asp Ile Ile Thr Trp Met Met Cys 
865                 870                 875                 880 


Arg Asp Leu Met Glu Glu Asn Lys Val Glu Gly Leu Asp Thr Gly Thr 
                885                 890                 895     


Leu Tyr Leu Lys Asp Ile Arg Thr Asp Val Tyr Glu Gln Gly Ser Leu 
            900                 905                 910         


Asn Val Leu Asn Arg Val Lys Pro Met Arg Leu Pro Val Ala Val Tyr 
        915                 920                 925             


Arg Ala Asp Ser Arg Gly His Val His Lys Glu Gln Ala Pro Leu Ala 
    930                 935                 940                 


Thr Val Tyr Ile Glu Glu Arg Asp Thr Lys Leu Leu Lys Gln Gly Asn 
945                 950                 955                 960 


Phe Lys Ser Phe Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe 
                965                 970                 975     


Val Asp Thr Gly Gly Leu Ala Met Glu Gln Tyr Pro Ile Ser Lys Leu 
            980                 985                 990         


Arg Val Glu Tyr Glu Leu Ala Lys  Tyr Gln Thr Ala Arg  Val Cys Ala 
        995                 1000                 1005             


Phe Glu  Gln Thr Leu Glu Leu  Glu Glu Ser Leu Leu  Thr Arg Tyr 
    1010                 1015                 1020             


Pro His  Leu Pro Asp Glu Ser  Phe Arg Glu Met Leu  Glu Ser Trp 
    1025                 1030                 1035             


Ser Asp  Pro Leu Leu Asp Lys  Trp Pro Asp Leu His  Arg Lys Val 
    1040                 1045                 1050             


Arg Leu  Leu Ile Ala Val Arg  Asn Ala Phe Ser His  Asn Gln Tyr 
    1055                 1060                 1065             


Pro Met  Tyr Asp Glu Ala Val  Phe Ser Ser Ile Arg  Lys Tyr Asp 
    1070                 1075                 1080             


Pro Phe  Ser Pro Asp Ala Ile  Glu Glu Arg Met Gly  Leu Asn Ile 
    1085                 1090                 1095             


Ala His  Arg Leu Ser Glu Glu  Val Lys Gln Ala Lys  Glu Met Ala 
    1100                 1105                 1110             


Glu Arg  Ile Ile Gln Ala 
    1115                 


<210>  2442
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2442

Val Asn Ala Asn Leu Glu Lys Lys Leu Ala Lys Lys Lys Val Gln Arg 
1               5                   10                  15      


Pro Leu Trp Arg Lys Leu Leu Leu Ala Asn Glu Glu Leu Ile Leu Ile 
            20                  25                  30          


Phe Val Leu Leu Leu Ile Tyr Cys Tyr Phe Cys Tyr Thr Arg Lys Val 
        35                  40                  45              


Ile Tyr Lys Lys Ile Glu Lys Tyr Gly Leu Ser Ser Lys Lys Lys Ile 
    50                  55                  60                  


Leu Asn Ser Arg Ile Val Asn Ser Lys Asn Ile Lys Ser Leu Ile Met 
65                  70                  75                  80  


Asp Thr Lys Thr Asn Asn Asn Ser Lys Asn Tyr Asn Leu Gln Ala Val 
                85                  90                  95      


Phe Ala Leu Tyr Leu Asn Gln Ala Glu His Asn Leu Glu Lys Ala Ile 
            100                 105                 110         


Lys Glu Val Thr Asp Gln Lys Gly Glu Val Arg Trp Asn Arg Lys Val 
        115                 120                 125             


Phe Ile Glu Ser Ile Asn Glu Leu Ser Phe Glu Gln Leu Tyr Lys Leu 
    130                 135                 140                 


Glu Tyr Lys Tyr Phe Ser Phe Leu Arg Ile Asn Ser Asn Asn Lys Glu 
145                 150                 155                 160 


Lys Tyr Arg Tyr Phe Ser Glu Phe Ile Asp Lys Asn Leu Glu Asp Lys 
                165                 170                 175     


Thr Lys Asn Glu Lys Thr Lys Glu Glu Glu Ile Phe Glu Ile Lys Lys 
            180                 185                 190         


Lys Ile Leu Leu Tyr Thr Tyr Lys Gln Leu Asp Asp Phe Arg Asn Tyr 
        195                 200                 205             


Tyr Ser His Phe Tyr His Ser Ile Tyr Asn Ala Asn Gly Glu Asn Ile 
    210                 215                 220                 


Phe Glu Ile Lys Asp Thr Asp Glu Arg Lys Lys Phe Leu Lys Glu Phe 
225                 230                 235                 240 


Leu Glu Val Arg Phe Arg Asp Ala Lys Asp Tyr Tyr Leu Asn Phe Thr 
                245                 250                 255     


Tyr Lys Thr Gln Glu Gly Leu Lys Asn Lys Tyr Asp Lys Ser Asn Phe 
            260                 265                 270         


Glu His Leu Asp Leu Asn Lys Lys Tyr Tyr Gln Phe Phe His Lys Asp 
        275                 280                 285             


Asp Ser Lys Asn Tyr Tyr Leu Phe Asp Asn Gly Leu Glu Lys Glu Asn 
    290                 295                 300                 


Tyr Lys Ser Arg Val Phe Leu Ala Ser Phe Phe Leu Thr Lys His Gln 
305                 310                 315                 320 


Thr Asn Phe Leu Leu Ser Lys Val Thr Gly Phe Lys Asp Thr Arg Thr 
                325                 330                 335     


Pro Lys Glu Lys Ala Thr Arg Asp Phe Phe Lys His Phe Cys Met Lys 
            340                 345                 350         


Thr Asp Ser Asp Phe Thr Thr Glu Asn Pro Gln Val Lys Phe Phe Ile 
        355                 360                 365             


Asp Ala Phe Asn Tyr Leu Asn Lys Val Pro Gln Leu Val Tyr Glu Glu 
    370                 375                 380                 


Tyr Lys Lys Asp Ile Thr Asn Ser Ile Glu Asn Ile Leu Lys Asn Lys 
385                 390                 395                 400 


Lys Glu Lys Glu Arg Lys Thr Asn Phe Thr Glu Ile Gln Asn Glu Leu 
                405                 410                 415     


Lys Lys Ser Phe Lys Asn Lys Ser Val Leu Leu Lys Ile Ile Asp Asn 
            420                 425                 430         


Thr Glu Phe Glu Lys Asn Val Glu Asn Leu Ile Arg Asn Ser Lys Gly 
        435                 440                 445             


Ser Lys Asn Tyr Lys Asp Ile Leu Lys Asn Ala Ile Leu Asp Asn Ile 
    450                 455                 460                 


Arg Ile Arg Thr Ser Lys Asp Leu Phe Thr Glu Phe Ala Leu Gln Phe 
465                 470                 475                 480 


Ile Asp Asp Phe Lys Leu Phe Glu Lys Ile Arg Phe Lys Val Tyr Ser 
                485                 490                 495     


Gly Lys Met Thr Ala Lys Arg Val Glu Lys Lys Tyr Asp Asp Lys Val 
            500                 505                 510         


Phe Lys Lys Thr His Ile Glu Ser Glu Lys Val Tyr Ser Arg Ile Asn 
        515                 520                 525             


Glu Leu Glu Asn Asn Ser Glu Ile Glu Asn Asp Arg Lys Pro Gln Tyr 
    530                 535                 540                 


Phe Ile Lys Asn Asn Asn Val Phe Phe Glu Val Asp Leu Asp Gly Tyr 
545                 550                 555                 560 


Lys Gln Asn Ala Ser Met Ser Val His Glu Leu Arg Asn Leu Val Phe 
                565                 570                 575     


Ala Leu Leu Leu Asn Lys Asn Val Glu Gln Lys Ile Ile Asp Tyr Ile 
            580                 585                 590         


Lys Asn Tyr Arg Glu Phe Leu Leu Lys Asp Leu Lys Asn Val Lys Thr 
        595                 600                 605             


Lys Ile Asn Phe Thr Lys Ile Pro Lys Lys Asp Phe Pro Gln Tyr Ile 
    610                 615                 620                 


Asn Lys Tyr Lys His Gln Asp Lys Asp Gln Thr Gln Thr Asp Phe Lys 
625                 630                 635                 640 


Asp Lys Ile Lys Lys Arg Leu Glu Tyr Ile Lys Asn Thr Glu Val Gln 
                645                 650                 655     


Ser Asn Ile Lys Asn Leu Arg Lys Tyr Asp Lys Ile Arg Glu Ile Ile 
            660                 665                 670         


Lys Phe Val Asn Arg Phe Asn Ser Val Leu Arg Gly Gly Asp Arg Arg 
        675                 680                 685             


Gly Tyr Leu Asn Ile Glu Gln His Gln Lys Leu Glu Lys Leu Leu Gly 
    690                 695                 700                 


Thr Phe Pro Asn Ser Arg Asn Glu Leu Tyr Asn Phe Leu Glu Asn Glu 
705                 710                 715                 720 


Lys Ile Thr Thr Asn Phe Lys Asp Phe Lys Glu Leu Ile Lys Glu Lys 
                725                 730                 735     


Asp Leu Tyr Ser Ile Leu Lys Lys Ile Phe Asp Thr Tyr Lys Glu Trp 
            740                 745                 750         


Ser Glu Glu Ala Leu Lys Asp Leu Gly Lys Lys Asp Leu Glu Glu Leu 
        755                 760                 765             


Lys Ser Ile Gly Arg Val Ile Asn Val Thr Glu Pro Glu Tyr Ser Ser 
    770                 775                 780                 


Asp Arg Leu Ser Lys Asn Ile Asp Ile Phe Leu Lys Asn Ile Val Ile 
785                 790                 795                 800 


Pro Arg Gly Phe Ile Lys Arg Asn Phe Phe Glu Lys Thr Asn Ile Ser 
                805                 810                 815     


Glu Glu Ile Asp Lys Lys Val Gly Asp Lys Glu Ala Cys Ile Tyr Tyr 
            820                 825                 830         


Glu Lys Ile Asn Ile Leu Phe Glu Ile Ala Lys Asn Ala Asp Lys Asn 
        835                 840                 845             


Lys Asp Lys Arg Lys Lys Tyr Lys Ile Ala Lys Thr Leu Asn Glu Gln 
    850                 855                 860                 


Lys Leu Lys Asp Lys Leu Leu Tyr Leu Met Ala Lys Lys Tyr Leu Glu 
865                 870                 875                 880 


Asn Asn Phe Gly Asn Tyr Thr Asn Glu Lys Asp Ile Lys Ala Ser Val 
                885                 890                 895     


Asn Asn Ile Met Val Ala Thr Ser Ile Glu Asp Ile Leu Lys Asp Gly 
            900                 905                 910         


Ile Asp Phe Ile Ile Lys Lys Gly Asn Ser Pro Gln Asn Ser Lys Lys 
        915                 920                 925             


Ile Lys Phe Arg Asn Arg Glu Phe Asp Arg Ile Gly Thr Ile Leu Lys 
    930                 935                 940                 


Asp Lys Arg Leu Asn Lys Ile Leu Lys Thr Tyr Phe Glu Gly Glu Asp 
945                 950                 955                 960 


Thr Ile Tyr Tyr Ile Asn Arg Glu Lys Tyr Lys Glu Lys Lys Ser Asn 
                965                 970                 975     


Thr Glu Lys Ile Trp Asp Leu Gln Asp Val Leu Lys Arg Ile Asp Asp 
            980                 985                 990         


Glu Gln Phe Gln Ile Ile Asn Glu  Ile Leu Lys Met Glu  Glu Asn Ile 
        995                 1000                 1005             


Leu Ile  Asn Tyr Leu Ser Thr  Lys Ala His Ile Ser  Ala Glu Asp 
    1010                 1015                 1020             


Ala Pro  Gln Ile Ile Lys Lys  Ser Lys Lys Tyr Lys  Pro Asn Glu 
    1025                 1030                 1035             


Met Gln  Gln Lys Asp Glu Glu  Phe Gln Ile Ile Ala  Ser Leu Leu 
    1040                 1045                 1050             


Lys Asp  Lys Asn Ile Lys Asn  Lys Asn Arg Ile Glu  Thr Lys Glu 
    1055                 1060                 1065             


Leu Leu  Asn Ile Ile Asp Ile  Asn Asn Ser Ser Lys  Asn Asp Lys 
    1070                 1075                 1080             


Ile Asp  Trp Asp Lys Ile Lys  Pro Tyr Arg Asn Ser  Ala Tyr His 
    1085                 1090                 1095             


Asn Gly  Leu Pro Glu Asn Gly  Thr Phe Lys Lys Gly  Ile Glu Leu 
    1100                 1105                 1110             


Ile Lys  Gly Tyr Asn Ile Glu  Leu Ile Lys Arg Tyr  Asn Asn 
    1115                 1120                 1125         


<210>  2443
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2443

Val Asn Ala Asn Leu Glu Lys Lys Leu Ala Lys Lys Lys Val Gln Arg 
1               5                   10                  15      


Pro Leu Trp Arg Lys Leu Leu Leu Ala Asn Glu Glu Leu Ile Leu Ile 
            20                  25                  30          


Phe Val Leu Leu Leu Ile Tyr Cys Tyr Phe Cys Tyr Thr Arg Lys Val 
        35                  40                  45              


Ile Tyr Lys Lys Ile Glu Lys Tyr Gly Leu Ser Ser Lys Lys Lys Ile 
    50                  55                  60                  


Leu Asn Ser Arg Ile Val Asn Ser Lys Asn Ile Lys Ser Leu Ile Met 
65                  70                  75                  80  


Asp Thr Lys Thr Asn Asn Asn Ser Lys Asn Tyr Asn Leu Gln Ala Val 
                85                  90                  95      


Phe Ala Leu Tyr Leu Asn Gln Ala Glu His Asn Leu Glu Lys Ala Ile 
            100                 105                 110         


Lys Glu Val Thr Asp Gln Lys Gly Glu Val Arg Trp Asn Arg Lys Val 
        115                 120                 125             


Phe Ile Glu Ser Ile Asn Glu Leu Ser Phe Glu Gln Leu Tyr Lys Leu 
    130                 135                 140                 


Glu Tyr Lys Tyr Phe Ser Phe Leu Arg Ile Asn Ser Asn Asn Lys Glu 
145                 150                 155                 160 


Lys Tyr Arg Tyr Phe Ser Glu Phe Ile Asp Lys Asn Leu Glu Asp Lys 
                165                 170                 175     


Thr Lys Asn Glu Lys Thr Lys Glu Glu Glu Ile Phe Glu Ile Lys Lys 
            180                 185                 190         


Lys Ile Leu Leu Tyr Thr Tyr Lys Gln Leu Asp Asp Phe Arg Asn Tyr 
        195                 200                 205             


Tyr Ser His Phe Tyr His Ser Ile Tyr Asn Ala Asn Gly Glu Asn Ile 
    210                 215                 220                 


Phe Glu Ile Lys Asp Thr Asp Glu Arg Lys Lys Phe Leu Lys Glu Phe 
225                 230                 235                 240 


Leu Glu Val Arg Phe Arg Asp Ala Lys Asp Tyr Tyr Leu Asn Phe Thr 
                245                 250                 255     


Tyr Lys Thr Gln Glu Gly Leu Lys Asn Lys Tyr Asp Lys Ser Asn Phe 
            260                 265                 270         


Glu His Leu Asp Leu Asn Lys Lys Tyr Tyr Gln Phe Phe His Lys Asp 
        275                 280                 285             


Asp Ser Lys Asn Tyr Tyr Leu Phe Asp Asn Gly Leu Glu Lys Glu Asn 
    290                 295                 300                 


Tyr Lys Ser Arg Val Phe Leu Ala Ser Phe Phe Leu Thr Lys His Gln 
305                 310                 315                 320 


Thr Asn Phe Leu Leu Ser Lys Val Thr Gly Phe Lys Asp Thr Arg Thr 
                325                 330                 335     


Pro Lys Glu Lys Ala Thr Arg Asp Phe Phe Lys His Phe Cys Met Lys 
            340                 345                 350         


Thr Asp Ser Asp Phe Thr Thr Glu Asn Pro Gln Val Lys Phe Phe Ile 
        355                 360                 365             


Asp Ala Phe Asn Tyr Leu Asn Lys Val Pro Gln Leu Val Tyr Glu Glu 
    370                 375                 380                 


Tyr Lys Lys Asp Ile Thr Asn Ser Ile Glu Asn Ile Leu Lys Asn Lys 
385                 390                 395                 400 


Lys Glu Lys Glu Arg Lys Thr Asn Phe Thr Glu Ile Gln Asn Glu Leu 
                405                 410                 415     


Lys Lys Ser Phe Lys Asn Lys Ser Val Leu Leu Lys Ile Ile Asp Asn 
            420                 425                 430         


Thr Glu Phe Glu Lys Asn Val Glu Asn Leu Ile Arg Asn Ser Lys Gly 
        435                 440                 445             


Ser Lys Asn Tyr Lys Asp Ile Leu Lys Asn Ala Ile Leu Asp Asn Ile 
    450                 455                 460                 


Arg Ile Arg Thr Ser Lys Asp Leu Phe Thr Glu Phe Ala Leu Gln Phe 
465                 470                 475                 480 


Ile Asp Asp Phe Lys Leu Phe Glu Lys Ile Arg Phe Lys Val Tyr Ser 
                485                 490                 495     


Gly Lys Met Thr Ala Lys Arg Val Glu Lys Lys Tyr Asp Asp Lys Val 
            500                 505                 510         


Phe Lys Lys Thr His Ile Glu Ser Glu Lys Val Tyr Ser Arg Ile Asn 
        515                 520                 525             


Glu Leu Glu Asn Asn Ser Glu Ile Glu Asn Asp Arg Lys Pro Gln Tyr 
    530                 535                 540                 


Phe Ile Lys Asn Asn Asn Val Phe Phe Glu Val Asp Leu Asp Gly Tyr 
545                 550                 555                 560 


Lys Gln Asn Ala Ser Met Ser Val His Glu Leu Arg Asn Leu Val Phe 
                565                 570                 575     


Ala Leu Leu Leu Asn Lys Asn Val Glu Gln Lys Ile Ile Asp Tyr Ile 
            580                 585                 590         


Lys Asn Tyr Arg Glu Phe Leu Leu Lys Asp Leu Lys Asn Val Lys Thr 
        595                 600                 605             


Lys Ile Asn Phe Thr Lys Ile Pro Lys Lys Asp Phe Pro Gln Tyr Ile 
    610                 615                 620                 


Asn Lys Tyr Lys His Gln Asp Lys Asp Gln Thr Gln Thr Asp Phe Lys 
625                 630                 635                 640 


Asp Lys Ile Lys Lys Arg Leu Glu Tyr Ile Lys Asn Thr Glu Val Gln 
                645                 650                 655     


Ser Asn Ile Lys Asn Leu Arg Lys Tyr Asp Lys Ile Arg Glu Ile Ile 
            660                 665                 670         


Lys Phe Val Asn Arg Phe Asn Ser Val Leu Arg Gly Gly Asp Arg Arg 
        675                 680                 685             


Gly Tyr Leu Asn Ile Glu Gln His Gln Lys Leu Glu Lys Leu Leu Gly 
    690                 695                 700                 


Thr Phe Pro Asn Ser Arg Asn Glu Leu Tyr Asn Phe Leu Glu Asn Glu 
705                 710                 715                 720 


Lys Ile Thr Thr Asn Phe Lys Asp Phe Lys Glu Leu Ile Lys Glu Lys 
                725                 730                 735     


Asp Leu Tyr Ser Ile Leu Lys Lys Ile Phe Asp Thr Tyr Lys Glu Trp 
            740                 745                 750         


Ser Glu Glu Ala Leu Lys Asp Leu Gly Lys Lys Asp Leu Glu Glu Leu 
        755                 760                 765             


Lys Ser Ile Gly Arg Val Ile Asn Val Thr Glu Pro Glu Tyr Ser Ser 
    770                 775                 780                 


Asp Arg Leu Ser Lys Asn Ile Asp Ile Phe Leu Lys Asn Ile Val Ile 
785                 790                 795                 800 


Pro Arg Gly Phe Ile Lys Arg Asn Phe Phe Glu Lys Thr Asn Ile Ser 
                805                 810                 815     


Glu Glu Ile Asp Lys Lys Val Gly Asp Lys Glu Ala Cys Ile Tyr Tyr 
            820                 825                 830         


Glu Lys Ile Asn Ile Leu Phe Glu Ile Ala Lys Asn Ala Asp Lys Asn 
        835                 840                 845             


Lys Asp Lys Arg Lys Lys Tyr Lys Ile Ala Lys Thr Leu Asn Glu Gln 
    850                 855                 860                 


Lys Leu Lys Asp Lys Leu Leu Tyr Leu Met Ala Lys Lys Tyr Leu Glu 
865                 870                 875                 880 


Asn Asn Phe Gly Asn Tyr Thr Asn Glu Lys Asp Ile Lys Ala Ser Val 
                885                 890                 895     


Asn Asn Ile Met Val Ala Thr Ser Ile Glu Asp Ile Leu Lys Asp Gly 
            900                 905                 910         


Ile Asp Phe Ile Ile Lys Lys Gly Asn Ser Pro Gln Asn Ser Lys Lys 
        915                 920                 925             


Ile Lys Phe Arg Asn Arg Glu Phe Asp Arg Ile Gly Thr Ile Leu Lys 
    930                 935                 940                 


Asp Lys Arg Leu Asn Lys Ile Leu Lys Thr Tyr Phe Glu Gly Glu Asp 
945                 950                 955                 960 


Thr Ile Tyr Tyr Ile Asn Arg Glu Lys Tyr Lys Glu Lys Lys Ser Asn 
                965                 970                 975     


Thr Glu Lys Ile Trp Asp Leu Gln Asp Val Leu Lys Arg Ile Asp Asp 
            980                 985                 990         


Glu Gln Phe Gln Ile Ile Asn Glu  Ile Leu Lys Met Glu  Glu Asn Ile 
        995                 1000                 1005             


Leu Ile  Asn Tyr Leu Ser Thr  Lys Ala His Ile Ser  Ala Glu Asp 
    1010                 1015                 1020             


Ala Pro  Gln Ile Ile Lys Lys  Ser Lys Lys Tyr Lys  Pro Asn Glu 
    1025                 1030                 1035             


Met Gln  Gln Lys Asp Glu Glu  Phe Gln Ile Ile Ala  Ser Leu Leu 
    1040                 1045                 1050             


Lys Asp  Lys Asn Ile Lys Asn  Lys Asn Arg Ile Glu  Thr Lys Glu 
    1055                 1060                 1065             


Leu Leu  Asn Ile Ile Asp Ile  Asn Asn Ser Ser Lys  Asn Asp Lys 
    1070                 1075                 1080             


Ile Asp  Trp Asp Lys Ile Lys  Pro Tyr Arg Asn Ser  Ala Tyr His 
    1085                 1090                 1095             


Asn Gly  Leu Pro Glu Asn Gly  Thr Phe Lys Lys Gly  Ile Glu Leu 
    1100                 1105                 1110             


Ile Lys  Gly Tyr Asn Ile Glu  Leu Ile Lys Arg Tyr  Asn Asn 
    1115                 1120                 1125         


<210>  2444
<211>  1029
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2444

Met His Val Thr Thr Thr Asn Lys Pro Leu Leu Ala Ala Tyr Leu Asn 
1               5                   10                  15      


Met Ala Arg Asn Asn Cys Tyr Met Ala Leu Ser His Ile Ala Glu Leu 
            20                  25                  30          


Met Gly Lys Ser Ser Val Met Asn Glu Asp Ala Ile Gln Glu Cys Ala 
        35                  40                  45              


Val Ile Arg Ala Leu Ala Gly Asn Ile Lys Pro Asp Glu Ser Phe Arg 
    50                  55                  60                  


Ile Ile Asp Met Val Asp Gln His Phe Pro Phe Ile Arg Leu Leu Leu 
65                  70                  75                  80  


Lys Ser Arg Asn Asn Ser Ser Pro Thr Asp Tyr Ala Asn Cys Leu Thr 
                85                  90                  95      


Asp Phe Ile Lys Gln Leu Asn Glu Leu Arg Asn Phe His Thr His Gln 
            100                 105                 110         


Leu His Lys Pro Tyr Ile Thr Asp Ala Lys Val Val Ala Gln Leu Gln 
        115                 120                 125             


Phe Leu Phe Asp Ala Ser Arg Arg Glu Val Lys Lys Arg Phe Ser Leu 
    130                 135                 140                 


Glu Glu Gln Asp Val Lys His Leu Val Arg Lys Ser Ile Val Ile Ile 
145                 150                 155                 160 


Asp Asn Asn Lys Val Ala Val Glu Lys Glu Asn Tyr Val Tyr Ala Phe 
                165                 170                 175     


Ala Asn Lys Glu Gly Gln Phe Thr Asn Lys Gly Ile Ala Phe Leu Ile 
            180                 185                 190         


Ser Leu Phe Ile Glu Lys Lys Tyr Ala Tyr Leu Phe Leu Lys Gln Leu 
        195                 200                 205             


Ser Gly Phe Lys Asn Ser Asn Thr Lys Gln His Lys Ala Thr Leu Glu 
    210                 215                 220                 


Val Phe Cys Phe Tyr His Ile Arg Ile Pro Gln Pro Lys Leu Gln Ser 
225                 230                 235                 240 


Asn Asn Thr Lys Ile Gly Phe Leu Leu Asp Ala Leu Glu Glu Leu Lys 
                245                 250                 255     


Arg Cys Pro Ala Glu Leu Tyr Glu His Ile Ala Lys Asn Asp Lys Gln 
            260                 265                 270         


Arg Phe Lys Ser Ala Gly Ile Thr Glu Asp Thr Asn Asp Gln Pro Glu 
        275                 280                 285             


Ala Ile Leu Lys Arg Asn Gly Asp Arg Phe Ser Tyr Leu Ala Leu Arg 
    290                 295                 300                 


Tyr Leu Glu Leu Thr Asn Ser Leu Pro Gly Leu Gln Phe Tyr Phe Asp 
305                 310                 315                 320 


Leu Gly Lys Tyr Tyr Phe Lys Val Tyr Glu Lys Ser Ile Asp Ser Glu 
                325                 330                 335     


Leu Arg Leu Arg Arg Leu His Lys Asn Met Arg Asp Phe Gly Arg Thr 
            340                 345                 350         


Asn Asp Phe Asp Thr Val Lys Met Pro Gln Leu Trp Gln Gln Leu Ile 
        355                 360                 365             


Lys Arg Thr Asp Glu Leu Ser Glu Asn Tyr Ala Glu Pro Tyr Ile Val 
    370                 375                 380                 


Tyr Thr Ile Pro His Tyr His Ile Val Asn Asn Gln Ile Gly Ile Trp 
385                 390                 395                 400 


Leu Asn Lys Glu Arg Gln Met Pro Ser Leu Thr Pro Lys Ile Ser Asn 
                405                 410                 415     


Ala Glu Pro Gln Ile Trp Leu Ser Leu Tyr Glu Leu Pro Ala Leu Leu 
            420                 425                 430         


Phe Tyr His Leu Leu Thr Lys Gly Asn Lys Gly Gln Lys Asn Val Leu 
        435                 440                 445             


Gln Ile Leu Ser Lys His Arg Thr Ala Ile His Ser Phe Phe Lys Asp 
    450                 455                 460                 


Ile Glu Ser Ser Lys Leu Leu Pro Gly Phe Thr Ile Glu Thr Leu Asn 
465                 470                 475                 480 


Val Glu Leu Glu Lys Arg Asn Leu Lys His Asp Lys Ile Pro Lys Pro 
                485                 490                 495     


Leu Leu Gln Tyr Leu Leu Gln Gln Lys Pro Leu Lys Ser Ile Val Glu 
            500                 505                 510         


Ile Ala Gly Glu Arg Leu Ser Glu Leu Gln Asn Glu Thr Ile Phe Leu 
        515                 520                 525             


Leu Asp Lys Ile Asp Ile Asp Ile Glu Lys Ala Lys Glu Lys Ile Gly 
    530                 535                 540                 


Gly Lys His Tyr Arg Pro Ile Gln Thr Gly Lys Ile Ala Asp Phe Leu 
545                 550                 555                 560 


Ala Arg Asp Met Leu Phe Phe Gln Pro Ala Ile Asp Lys Ile Lys Gly 
                565                 570                 575     


Lys Ala Thr Ser Thr Leu Phe Gln Val Leu Gln Ala Arg Leu Ala Phe 
            580                 585                 590         


Tyr Gly Arg Asp Lys Glu Leu Leu Glu Gly Leu Tyr Lys Glu Cys Asn 
        595                 600                 605             


Leu Ile Gln Ser Lys Asn Pro His Pro Phe Leu Ser Gly Leu Pro Ile 
    610                 615                 620                 


Thr Asn Asn Leu Met Asp Tyr Tyr Arg Asn Tyr Leu Ile Lys Arg Asn 
625                 630                 635                 640 


Gln Tyr Leu Asp Lys Cys Leu Lys Lys Cys Lys Gln Gly Lys Ile Gly 
                645                 650                 655     


Ser Gln Asp Phe His Phe Leu His Leu Gly Glu Arg Glu Arg Lys Asn 
            660                 665                 670         


Gly Asn Thr Tyr Tyr Thr Asn Leu Ala Gly Lys Phe Ile Lys Met Pro 
        675                 680                 685             


Leu Asn Phe Pro Arg Gly Leu Phe Met Glu Glu Leu Ile Asn Tyr Phe 
    690                 695                 700                 


Glu Ser Ser Gly Asp Leu His Met Gln Asn Ile Ile Lys Asn Thr Pro 
705                 710                 715                 720 


Arg Leu Ser Thr Thr Phe Leu Leu Lys Glu Tyr Ile Asn Asn Val Leu 
                725                 730                 735     


Ser Asp Asp Thr Pro Asp Phe Tyr Asn Trp Lys Arg Ser Tyr Thr Val 
            740                 745                 750         


Phe Asn Arg Tyr Tyr Asp Lys Arg Lys Gln Asn Ser Arg Asp Ala Ile 
        755                 760                 765             


Thr Lys Ile Tyr Phe Asp Thr Ser Gln Leu Ser Glu Glu Ala Asn Lys 
    770                 775                 780                 


Ile Lys Ala Ala Ile Lys Lys Ile Glu Lys Ser Asp Ile Lys Gly Ala 
785                 790                 795                 800 


Glu Ser Ile Lys Arg Asn Tyr Lys Phe Tyr Gly Asp Asn Glu Lys Gln 
                805                 810                 815     


Leu Arg Gln Ala Lys Ala Cys Asp Thr Ile Leu Phe Leu Ala Ile Arg 
            820                 825                 830         


Asp Leu Phe Pro Thr Ile Glu Ser Ser Val Phe Lys Gly Leu Ala Ile 
        835                 840                 845             


Glu Gln Phe Arg Leu Ser Asp Ile Leu Pro Asp Ala Glu Lys Gly Ile 
    850                 855                 860                 


Leu Ser Gln Ser Ile Glu Ile Arg Leu Pro Leu Tyr Asn Lys Phe Ile 
865                 870                 875                 880 


Ile Gln Lys Gly Leu Lys Leu Lys Asn Tyr Gly Asp Phe Arg Arg Phe 
                885                 890                 895     


Leu Lys Asp Arg Arg Leu Glu Ser Leu Met Pro Tyr Phe Glu Glu Asp 
            900                 905                 910         


Asp Ile Asp Arg Ser Ser Leu Glu Lys Glu Leu Glu Asp Tyr Asp Thr 
        915                 920                 925             


Ala Arg Ile Glu Ile His Arg Val Val Leu Asp Phe Glu Ser His Val 
    930                 935                 940                 


Ile Thr Met Tyr Gln Leu Asn Tyr Leu Asn Pro Glu Asp Pro Cys Ile 
945                 950                 955                 960 


Asn His Glu Thr Ile Leu Asn Cys Phe Phe Gln Asn Asp Pro Ser Asp 
                965                 970                 975     


Ile Arg Lys Gln Leu Met Glu Asn Ile Arg Asn Arg Phe Ser His Asn 
            980                 985                 990         


Glu Tyr Pro Asp Phe Glu Lys Phe  Lys Glu Ile Ile Gln  Glu Asn His 
        995                 1000                 1005             


Gln Gln  Lys Thr Ile Ala Gly  Lys Phe Val Thr Leu  Ala Asn Gln 
    1010                 1015                 1020             


Tyr Phe  Ser Val Glu Glu 
    1025                 


<210>  2445
<211>  1166
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1071)..(1163)
<223>  Xaa can be any naturally occurring amino acid

<400>  2445

Met Ile Asn Asn Lys Asn Thr Asn Gln Ala Phe Trp Ala Ala Tyr Ser 
1               5                   10                  15      


Asn Val Ala Ala Tyr Asn Val Ala Ile Ile Ile Ala His Ile Asn Ser 
            20                  25                  30          


Lys Ile Glu Asn Lys Thr Lys Glu Ala Asp Glu Glu Ser Leu Gly Lys 
        35                  40                  45              


Ile Glu Asp Leu Phe Asp Met Val Cys Val Asp Asn Pro Asn Asn Lys 
    50                  55                  60                  


Lys Lys Ile Asp Phe Leu Tyr Lys Tyr Met Pro Phe Ile Trp Leu Phe 
65                  70                  75                  80  


Val Asp Tyr Ile Tyr Asn Gln Asp Lys Thr Ser Asn Gly Ile Pro Phe 
                85                  90                  95      


Phe Glu Lys Arg Ile Ile Asn Asn Asn Asp Lys Asn Asp Val Glu Ser 
            100                 105                 110         


Arg Glu Val Thr Leu Thr Glu Gln Ile Glu Ile Ile Lys Glu Leu Phe 
        115                 120                 125             


Gln Leu Leu Leu Asp Ile Arg Asn Asn Gln Ser His Phe Val Gly Ser 
    130                 135                 140                 


Asn Tyr Phe Val Asn Asp Ser Met Phe Arg Ala Leu Glu Tyr Cys Phe 
145                 150                 155                 160 


Asp Val Ser Leu Arg Thr Thr Ile Thr Arg Phe Trp Asp Asp Ala Lys 
                165                 170                 175     


Asp Ala Asn Asn Lys Leu Glu His Leu Lys Arg His Asp Asn Lys Gly 
            180                 185                 190         


Lys Ile Lys Lys Glu Phe Ile Tyr Lys Phe Lys Asn Ile Gly Val Asp 
        195                 200                 205             


Lys Asn Asn Phe Thr Thr Asn Gly Leu Ala Phe Phe Leu Cys Leu Phe 
    210                 215                 220                 


Leu Asp Lys Arg Met Ser Lys Leu Met Leu Asp Gln Ile Ser Gly Phe 
225                 230                 235                 240 


Lys Arg Asn Asp Ser Lys Glu Tyr Arg Ala Thr Ile Asn Val Phe Thr 
                245                 250                 255     


Ile Asp Arg Ile Arg Leu Pro Lys Glu Lys Ile Glu Ser Val Phe Ser 
            260                 265                 270         


Leu Asp Ser Leu Gly Leu Asp Ile Ile Asn Glu Leu Gln Lys Cys Pro 
        275                 280                 285             


Lys Glu Leu Tyr Asp Leu Leu Ser Gln Glu Asp Arg Asn Lys Phe Val 
    290                 295                 300                 


Leu Ile Asp Glu Glu Thr Glu Asp Glu Thr Ile Leu Lys Arg Ser Gln 
305                 310                 315                 320 


Asn Arg Phe Ser Tyr Phe Val Met Arg Tyr Phe Asp Glu Lys Glu Ile 
                325                 330                 335     


Phe Lys Asn Ile Arg Phe His Ile Asp Leu Gly Leu Tyr Asn Lys Asp 
            340                 345                 350         


Cys Tyr Glu Lys Thr Leu Lys Asp Gly Ser Lys Leu Glu Asp Arg Phe 
        355                 360                 365             


Ile Ser Lys Arg Leu Lys Gly Phe Gly Arg Ile Gln Glu Met Asn Thr 
    370                 375                 380                 


Glu Phe Glu Lys His Lys Lys Glu Tyr Pro Asp Phe Tyr Val Gln Asp 
385                 390                 395                 400 


Lys Asn Glu Lys Asn Tyr Gln Ile Pro Asn Arg Met Pro Thr Phe Pro 
                405                 410                 415     


His Tyr His Tyr Ala Asn Glu Glu Lys Thr Leu Ile Gly Leu Lys Ile 
            420                 425                 430         


Lys Asp Lys Val Asp Tyr Lys Tyr Ser Asp Ile Glu Arg Asn Asn Phe 
        435                 440                 445             


Ile Leu Glu Lys Pro Asp Ala Tyr Ile Ser Thr Tyr Glu Phe Pro Ala 
    450                 455                 460                 


Met Tyr Phe Cys Glu Tyr Leu Lys Gly Asn Pro Glu Gln Val Leu Ile 
465                 470                 475                 480 


Asp Thr Tyr Asn Thr Ile Ile Asp Phe Leu Lys Lys Ile Ala Ser Asn 
                485                 490                 495     


Asp Asn Ser Ile Glu Ile Phe Arg Asp Glu Ile Thr Gly Lys Thr Glu 
            500                 505                 510         


Asp Glu Ile Lys Glu Leu Phe Lys Asn Glu Phe Lys Leu Asp Ile Asn 
        515                 520                 525             


Asp Ile Pro Lys Glu Leu Lys Val Tyr Ile Ser Thr Lys Pro Ala Lys 
    530                 535                 540                 


Ser Lys Asn Thr Tyr Gln Glu Tyr Leu Lys Gln Lys Met Asp Thr Met 
545                 550                 555                 560 


Leu Glu Glu Ala Lys Lys Glu Tyr Gly Trp Ile Ile Asp Lys Glu Asn 
                565                 570                 575     


Arg Ile Lys Glu Arg Arg Ile Lys Ala Gly Lys Lys Asn Tyr Glu Lys 
            580                 585                 590         


Ile Asn Ile Gly Asp Ile Ala Leu Lys Leu Val Lys Asp Ile Ile Tyr 
        595                 600                 605             


Leu Thr Pro Ile Ser Ser Lys Asn Asn Gly Lys Asp Gly Ile Thr Ser 
    610                 615                 620                 


Pro Asn Tyr Asn Arg Leu Gln Glu His Phe Ala Leu Trp Val Glu Lys 
625                 630                 635                 640 


Glu Arg Arg Phe Lys Ala Ile Glu Ile Leu Asn Ala Phe Lys Ile Phe 
                645                 650                 655     


Asp Lys His Pro Phe Leu Asn Lys Leu Gly Lys Ile Glu Asp Ile Ser 
            660                 665                 670         


Ser Ile Val Ile Leu Tyr Lys Ala Tyr Met Leu Ser Lys Ile Asn Tyr 
        675                 680                 685             


Leu Asn Glu Lys Ala Val Lys Gly Lys Tyr Gly Ile Asp Ile Leu Ser 
    690                 695                 700                 


Asn Asp Lys Glu Asn Lys Lys Ala Leu Asp Tyr Glu Thr Tyr Ser Ile 
705                 710                 715                 720 


Asp Leu Ala Lys Lys Leu Leu Glu Leu Pro Ile Asn Leu Pro Arg Asn 
                725                 730                 735     


Met Phe Tyr Glu Glu Ile Val Lys Ser Lys Glu Leu Glu Thr Leu Arg 
            740                 745                 750         


Arg Tyr Ile Tyr Gly Lys Arg Ala Asn Val Ser Tyr Leu Ile Lys Leu 
        755                 760                 765             


Tyr Leu Asn Glu Lys Leu Lys Asp Asp Ser Gln Glu Phe Tyr Lys Tyr 
    770                 775                 780                 


Asp Arg Met Tyr Lys Phe Phe Lys Glu Gly Arg Asn Asn Lys Asn Val 
785                 790                 795                 800 


Tyr His Glu Leu Asn Arg Phe Asp Glu Lys Val Ser Glu Ile Lys Glu 
                805                 810                 815     


Gln Ile Lys Asn Asn Gln Asp Asn Pro Asn Tyr Lys Phe Tyr Lys Gln 
            820                 825                 830         


Phe Thr Glu Asn Glu Lys Gln Leu Arg Leu Leu Gln Thr Gln Asp Val 
        835                 840                 845             


Leu Leu Phe Leu Met Ala Lys Ser Ile Leu Phe Asn Glu Val Glu Thr 
    850                 855                 860                 


Lys Phe Ile Asp Lys Thr Ile Gln Ser Glu Ser Ile Leu Leu Lys Asn 
865                 870                 875                 880 


Ile Gly Ile Gly Gly Lys Ser Val Leu Glu Glu Lys Thr Lys Val Asn 
                885                 890                 895     


Leu Ser Leu Ser Val Ala Asp Tyr Tyr Leu Phe Ile Glu Asp Thr Leu 
            900                 905                 910         


Lys Ile Lys Asn Tyr Gly Asp Phe Lys Tyr Phe Cys Phe Asp Lys Arg 
        915                 920                 925             


Val Ser Asn Tyr Leu Glu Cys Leu Leu Lys Thr Phe Asn Asp Asn Gln 
    930                 935                 940                 


Tyr Lys Lys Gly Gly Asn Pro Tyr Lys Ile Lys Arg Gln Glu Ile Glu 
945                 950                 955                 960 


Lys Glu Leu Glu Asn Tyr Glu Thr Tyr Arg Ile Ala Ala Phe Glu Lys 
                965                 970                 975     


Ile Leu Glu Phe Glu Arg Ile Phe Phe Gln Asn Tyr Tyr Thr Lys Glu 
            980                 985                 990         


Glu Phe Glu Ser Ile Asn Asn Gly  Thr His Phe Ser Phe  Glu Lys Ile 
        995                 1000                 1005             


Ile Lys  Glu Phe Ile Glu Lys  Thr Asn Ala Glu Ser  Glu Ile Cys 
    1010                 1015                 1020             


Lys Leu  Ile Lys Ser Thr Arg  Asn Ala Phe Ser His  Ser Gln Tyr 
    1025                 1030                 1035             


Pro Met  Gln Asp Asn Trp Leu  Arg Asn Arg Ile Asp  Glu Lys Asn 
    1040                 1045                 1050             


Lys Ser  Asn Met Leu Asp Ile  Ile Tyr Asn Asp Phe  Ser Glu Ser 
    1055                 1060                 1065             


Ile Glu  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1070                 1075                 1080             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1085                 1090                 1095             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1100                 1105                 1110             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1115                 1120                 1125             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1130                 1135                 1140             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1145                 1150                 1155             


Xaa Xaa  Xaa Xaa Xaa Phe Glu  Arg 
    1160                 1165     


<210>  2446
<211>  1071
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (1071)..(1071)
<223>  Xaa can be any naturally occurring amino acid

<400>  2446

Met Ile Asn Asn Lys Asn Thr Asn Gln Ala Phe Trp Ala Ala Tyr Ser 
1               5                   10                  15      


Asn Val Ala Ala Tyr Asn Val Ala Ile Ile Ile Ala His Ile Asn Ser 
            20                  25                  30          


Lys Ile Glu Asn Lys Thr Lys Glu Ala Asp Glu Glu Ser Leu Gly Lys 
        35                  40                  45              


Ile Glu Asp Leu Phe Asp Met Val Cys Val Asp Asn Pro Asn Asn Lys 
    50                  55                  60                  


Lys Lys Ile Asp Phe Leu Tyr Lys Tyr Met Pro Phe Ile Trp Leu Phe 
65                  70                  75                  80  


Val Asp Tyr Ile Tyr Asn Gln Asp Lys Thr Ser Asn Gly Ile Pro Phe 
                85                  90                  95      


Phe Glu Lys Arg Ile Ile Asn Asn Asn Asp Lys Asn Asp Val Glu Ser 
            100                 105                 110         


Arg Glu Val Thr Leu Thr Glu Gln Ile Glu Ile Ile Lys Glu Leu Phe 
        115                 120                 125             


Gln Leu Leu Leu Asp Ile Arg Asn Asn Gln Ser His Phe Val Gly Ser 
    130                 135                 140                 


Asn Tyr Phe Val Asn Asp Ser Met Phe Arg Ala Leu Glu Tyr Cys Phe 
145                 150                 155                 160 


Asp Val Ser Leu Arg Thr Thr Ile Thr Arg Phe Trp Asp Asp Ala Lys 
                165                 170                 175     


Asp Ala Asn Asn Lys Leu Glu His Leu Lys Arg His Asp Asn Lys Gly 
            180                 185                 190         


Lys Ile Lys Lys Glu Phe Ile Tyr Lys Phe Lys Asn Ile Gly Val Asp 
        195                 200                 205             


Lys Asn Asn Phe Thr Thr Asn Gly Leu Ala Phe Phe Leu Cys Leu Phe 
    210                 215                 220                 


Leu Asp Lys Arg Met Ser Lys Leu Met Leu Asp Gln Ile Ser Gly Phe 
225                 230                 235                 240 


Lys Arg Asn Asp Ser Lys Glu Tyr Arg Ala Thr Ile Asn Val Phe Thr 
                245                 250                 255     


Ile Asp Arg Ile Arg Leu Pro Lys Glu Lys Ile Glu Ser Val Phe Ser 
            260                 265                 270         


Leu Asp Ser Leu Gly Leu Asp Ile Ile Asn Glu Leu Gln Lys Cys Pro 
        275                 280                 285             


Lys Glu Leu Tyr Asp Leu Leu Ser Gln Glu Asp Arg Asn Lys Phe Val 
    290                 295                 300                 


Leu Ile Asp Glu Glu Thr Glu Asp Glu Thr Ile Leu Lys Arg Ser Gln 
305                 310                 315                 320 


Asn Arg Phe Ser Tyr Phe Val Met Arg Tyr Phe Asp Glu Lys Glu Ile 
                325                 330                 335     


Phe Lys Asn Ile Arg Phe His Ile Asp Leu Gly Leu Tyr Asn Lys Asp 
            340                 345                 350         


Cys Tyr Glu Lys Thr Leu Lys Asp Gly Ser Lys Leu Glu Asp Arg Phe 
        355                 360                 365             


Ile Ser Lys Arg Leu Lys Gly Phe Gly Arg Ile Gln Glu Met Asn Thr 
    370                 375                 380                 


Glu Phe Glu Lys His Lys Lys Glu Tyr Pro Asp Phe Tyr Val Gln Asp 
385                 390                 395                 400 


Lys Asn Glu Lys Asn Tyr Gln Ile Pro Asn Arg Met Pro Thr Phe Pro 
                405                 410                 415     


His Tyr His Tyr Ala Asn Glu Glu Lys Thr Leu Ile Gly Leu Lys Ile 
            420                 425                 430         


Lys Asp Lys Val Asp Tyr Lys Tyr Ser Asp Ile Glu Arg Asn Asn Phe 
        435                 440                 445             


Ile Leu Glu Lys Pro Asp Ala Tyr Ile Ser Thr Tyr Glu Phe Pro Ala 
    450                 455                 460                 


Met Tyr Phe Cys Glu Tyr Leu Lys Gly Asn Pro Glu Gln Val Leu Ile 
465                 470                 475                 480 


Asp Thr Tyr Asn Thr Ile Ile Asp Phe Leu Lys Lys Ile Ala Ser Asn 
                485                 490                 495     


Asp Asn Ser Ile Glu Ile Phe Arg Asp Glu Ile Thr Gly Lys Thr Glu 
            500                 505                 510         


Asp Glu Ile Lys Glu Leu Phe Lys Asn Glu Phe Lys Leu Asp Ile Asn 
        515                 520                 525             


Asp Ile Pro Lys Glu Leu Lys Val Tyr Ile Ser Thr Lys Pro Ala Lys 
    530                 535                 540                 


Ser Lys Asn Thr Tyr Gln Glu Tyr Leu Lys Gln Lys Met Asp Thr Met 
545                 550                 555                 560 


Leu Glu Glu Ala Lys Lys Glu Tyr Gly Trp Ile Ile Asp Lys Glu Asn 
                565                 570                 575     


Arg Ile Lys Glu Arg Arg Ile Lys Ala Gly Lys Lys Asn Tyr Glu Lys 
            580                 585                 590         


Ile Asn Ile Gly Asp Ile Ala Leu Lys Leu Val Lys Asp Ile Ile Tyr 
        595                 600                 605             


Leu Thr Pro Ile Ser Ser Lys Asn Asn Gly Lys Asp Gly Ile Thr Ser 
    610                 615                 620                 


Pro Asn Tyr Asn Arg Leu Gln Glu His Phe Ala Leu Trp Val Glu Lys 
625                 630                 635                 640 


Glu Arg Arg Phe Lys Ala Ile Glu Ile Leu Asn Ala Phe Lys Ile Phe 
                645                 650                 655     


Asp Lys His Pro Phe Leu Asn Lys Leu Gly Lys Ile Glu Asp Ile Ser 
            660                 665                 670         


Ser Ile Val Ile Leu Tyr Lys Ala Tyr Met Leu Ser Lys Ile Asn Tyr 
        675                 680                 685             


Leu Asn Glu Lys Ala Val Lys Gly Lys Tyr Gly Ile Asp Ile Leu Ser 
    690                 695                 700                 


Asn Asp Lys Glu Asn Lys Lys Ala Leu Asp Tyr Glu Thr Tyr Ser Ile 
705                 710                 715                 720 


Asp Leu Ala Lys Lys Leu Leu Glu Leu Pro Ile Asn Leu Pro Arg Asn 
                725                 730                 735     


Met Phe Tyr Glu Glu Ile Val Lys Ser Lys Glu Leu Glu Thr Leu Arg 
            740                 745                 750         


Arg Tyr Ile Tyr Gly Lys Arg Ala Asn Val Ser Tyr Leu Ile Lys Leu 
        755                 760                 765             


Tyr Leu Asn Glu Lys Leu Lys Asp Asp Ser Gln Glu Phe Tyr Lys Tyr 
    770                 775                 780                 


Asp Arg Met Tyr Lys Phe Phe Lys Glu Gly Arg Asn Asn Lys Asn Val 
785                 790                 795                 800 


Tyr His Glu Leu Asn Arg Phe Asp Glu Lys Val Ser Glu Ile Lys Glu 
                805                 810                 815     


Gln Ile Lys Asn Asn Gln Asp Asn Pro Asn Tyr Lys Phe Tyr Lys Gln 
            820                 825                 830         


Phe Thr Glu Asn Glu Lys Gln Leu Arg Leu Leu Gln Thr Gln Asp Val 
        835                 840                 845             


Leu Leu Phe Leu Met Ala Lys Ser Ile Leu Phe Asn Glu Val Glu Thr 
    850                 855                 860                 


Lys Phe Ile Asp Lys Thr Ile Gln Ser Glu Ser Ile Leu Leu Lys Asn 
865                 870                 875                 880 


Ile Gly Ile Gly Gly Lys Ser Val Leu Glu Glu Lys Thr Lys Val Asn 
                885                 890                 895     


Leu Ser Leu Ser Val Ala Asp Tyr Tyr Leu Phe Ile Glu Asp Thr Leu 
            900                 905                 910         


Lys Ile Lys Asn Tyr Gly Asp Phe Lys Tyr Phe Cys Phe Asp Lys Arg 
        915                 920                 925             


Val Ser Asn Tyr Leu Glu Cys Leu Leu Lys Thr Phe Asn Asp Asn Gln 
    930                 935                 940                 


Tyr Lys Lys Gly Gly Asn Pro Tyr Lys Ile Lys Arg Gln Glu Ile Glu 
945                 950                 955                 960 


Lys Glu Leu Glu Asn Tyr Glu Thr Tyr Arg Ile Ala Ala Phe Glu Lys 
                965                 970                 975     


Ile Leu Glu Phe Glu Arg Ile Phe Phe Gln Asn Tyr Tyr Thr Lys Glu 
            980                 985                 990         


Glu Phe Glu Ser Ile Asn Asn Gly  Thr His Phe Ser Phe  Glu Lys Ile 
        995                 1000                 1005             


Ile Lys  Glu Phe Ile Glu Lys  Thr Asn Ala Glu Ser  Glu Ile Cys 
    1010                 1015                 1020             


Lys Leu  Ile Lys Ser Thr Arg  Asn Ala Phe Ser His  Ser Gln Tyr 
    1025                 1030                 1035             


Pro Met  Gln Asp Asn Trp Leu  Arg Asn Arg Ile Asp  Glu Lys Asn 
    1040                 1045                 1050             


Lys Ser  Asn Met Leu Asp Ile  Ile Tyr Asn Asp Phe  Ser Glu Ser 
    1055                 1060                 1065             


Ile Glu  Xaa 
    1070     


<210>  2447
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2447

Leu Gln Lys Gln Asp Lys Leu Phe Val Asp Arg Lys Lys Asn Ala Ile 
1               5                   10                  15      


Phe Ala Phe Pro Lys Tyr Ile Thr Ile Met Glu Asn Lys Glu Lys Pro 
            20                  25                  30          


Glu Pro Ile Tyr Tyr Glu Leu Thr Asp Lys His Phe Trp Ala Ala Phe 
        35                  40                  45              


Leu Asn Leu Ala Arg His Asn Val Tyr Thr Thr Ile Asn His Ile Asn 
    50                  55                  60                  


Arg Arg Leu Glu Ile Ala Glu Leu Lys Asp Asp Gly Tyr Met Met Gly 
65                  70                  75                  80  


Ile Lys Gly Ser Trp Asn Glu Gln Ala Lys Lys Leu Asp Lys Lys Val 
                85                  90                  95      


Arg Leu Arg Asp Leu Ile Met Lys His Phe Pro Phe Leu Glu Ala Ala 
            100                 105                 110         


Ala Tyr Glu Ile Thr Asn Ser Lys Ser Ser Asn Asn Lys Glu Gln Arg 
        115                 120                 125             


Glu Lys Glu Gln Ser Glu Ala Leu Ser Leu Asn Asn Leu Lys Asn Val 
    130                 135                 140                 


Leu Phe Ile Phe Leu Glu Lys Leu Gln Val Leu Arg Asn Tyr Tyr Ser 
145                 150                 155                 160 


His Tyr Lys Tyr Ser Glu Glu Ser Pro Lys Pro Ile Phe Glu Thr Ser 
                165                 170                 175     


Leu Leu Lys Asn Met Tyr Lys Val Phe Asp Ala Asn Val Arg Leu Val 
            180                 185                 190         


Lys Arg Asp Tyr Met His His Glu Asn Ile Asp Met Gln Arg Asp Phe 
        195                 200                 205             


Thr His Leu Asn Arg Lys Lys Gln Val Gly Arg Thr Lys Asn Ile Ile 
    210                 215                 220                 


Asp Ser Pro Asn Phe His Tyr His Phe Ala Asp Lys Glu Gly Asn Met 
225                 230                 235                 240 


Thr Ile Ala Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Asp Lys Lys 
                245                 250                 255     


Asp Ala Ile Trp Met Gln Lys Lys Leu Lys Gly Phe Lys Asp Gly Arg 
            260                 265                 270         


Asn Leu Arg Glu Gln Met Thr Asn Glu Val Phe Cys Arg Ser Arg Ile 
        275                 280                 285             


Ser Leu Pro Lys Leu Lys Leu Glu Asn Val Gln Thr Lys Asp Trp Met 
    290                 295                 300                 


Gln Leu Asp Met Leu Asn Glu Leu Val Arg Cys Pro Lys Ser Leu Tyr 
305                 310                 315                 320 


Glu Arg Leu Arg Glu Lys Asp Arg Glu Ser Phe Lys Val Pro Phe Asp 
                325                 330                 335     


Ile Phe Ser Asp Asp Tyr Asp Ala Glu Glu Glu Pro Phe Lys Asn Thr 
            340                 345                 350         


Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe 
        355                 360                 365             


Asp Leu Asn Glu Ile Phe Glu Gln Leu Arg Phe Gln Ile Asp Leu Gly 
    370                 375                 380                 


Thr Tyr His Phe Ser Ile Tyr Asn Lys Arg Ile Gly Asp Glu Asp Glu 
385                 390                 395                 400 


Val Arg His Leu Thr His His Leu Tyr Gly Phe Ala Arg Ile Gln Asp 
                405                 410                 415     


Phe Ala Pro Gln Asn Gln Pro Glu Glu Trp Arg Lys Leu Val Lys Asp 
            420                 425                 430         


Leu Asp His Phe Glu Thr Ser Gln Glu Pro Tyr Ile Ser Lys Thr Ala 
        435                 440                 445             


Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Lys Phe Cys Ser 
    450                 455                 460                 


Thr His Asn Asn Leu Phe Pro Ser Leu Lys Arg Glu Lys Thr Cys Asn 
465                 470                 475                 480 


Gly Arg Ser Lys Phe Asn Leu Gly Thr Gln Phe Thr Ala Glu Ala Phe 
                485                 490                 495     


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu 
            500                 505                 510         


Thr Lys Asp His Pro Lys Gly Glu Gly Val Asn Lys Ile Glu Lys Ile 
        515                 520                 525             


Ile Arg Thr Glu Ile Ser Asn Ile Tyr Asp Ile Tyr Asp Ala Phe Ala 
    530                 535                 540                 


Asn Gly Glu Ile Asn Ser Ile Ala Asp Leu Thr Cys Arg Leu Gln Lys 
545                 550                 555                 560 


Thr Asn Ile Leu Gln Gly His Leu Pro Lys Gln Met Ile Ser Ile Leu 
                565                 570                 575     


Glu Gly Arg Gln Lys Asp Met Glu Lys Glu Ala Glu Arg Lys Ile Gly 
            580                 585                 590         


Glu Met Ile Asp Asp Thr Gln Arg Arg Leu Asp Leu Leu Cys Lys Gln 
        595                 600                 605             


Thr Asn Gln Lys Ile Arg Ile Gly Lys Arg Asn Ala Gly Leu Leu Lys 
    610                 615                 620                 


Ser Gly Lys Ile Ala Asp Trp Leu Val Asn Asp Met Met Arg Phe Gln 
625                 630                 635                 640 


Pro Val Gln Lys Asp Gln Asn Asn Ile Pro Ile Asn Asn Ser Lys Ala 
                645                 650                 655     


Asn Ser Thr Glu Tyr Arg Met Leu Gln Arg Ala Leu Ala Leu Phe Gly 
            660                 665                 670         


Ser Glu Asn Phe Arg Leu Lys Ala Tyr Phe Asn Gln Met Asn Leu Val 
        675                 680                 685             


Gly Asn Asp Asn Pro His Pro Phe Leu Ala Glu Thr Gln Trp Glu His 
    690                 695                 700                 


Gln Thr Asn Ile Leu Ser Phe Tyr Arg Asn Tyr Leu Glu Ala Arg Lys 
705                 710                 715                 720 


Lys Tyr Leu Lys Gly Leu Lys Pro Gln Asn Trp Lys Gln Tyr Gln His 
                725                 730                 735     


Phe Leu Ile Leu Lys Val Gln Lys Thr Asn Arg Asn Thr Leu Val Thr 
            740                 745                 750         


Gly Trp Lys Asn Ser Phe Asn Leu Pro Arg Gly Ile Phe Thr Gln Pro 
        755                 760                 765             


Ile Arg Glu Trp Phe Glu Lys His Asn Asn Ser Lys Arg Ile Tyr Asp 
    770                 775                 780                 


Gln Ile Leu Ser Phe Asp Arg Val Gly Phe Val Ala Lys Ala Ile Pro 
785                 790                 795                 800 


Leu Tyr Phe Thr Glu Glu Tyr Lys Asp Asn Val Gln Pro Phe Tyr Asp 
                805                 810                 815     


Tyr Pro Phe Asn Ile Gly Asn Lys Leu Lys Pro Gln Lys Gly Gln Phe 
            820                 825                 830         


Leu Asp Lys Lys Glu Arg Val Glu Leu Trp Gln Lys Asn Lys Glu Leu 
        835                 840                 845             


Phe Lys Asn Tyr Pro Ser Glu Lys Lys Lys Thr Asp Leu Ala Tyr Leu 
    850                 855                 860                 


Asp Phe Leu Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys 
865                 870                 875                 880 


Asn Gln Asp Ile Val Thr Trp Leu Met Phe Lys Glu Leu Phe Lys Thr 
                885                 890                 895     


Thr Thr Val Glu Glu Leu Lys Ile Gly Glu Ile His Leu Arg Asp Ile 
            900                 905                 910         


Asp Thr Asn Thr Ala Asn Glu Glu Ser Asn Asn Ile Leu Asn Arg Ile 
        915                 920                 925             


Met Pro Met Lys Leu Pro Val Lys Thr Tyr Glu Thr Asp Asn Lys Gly 
    930                 935                 940                 


Asn Ile Leu Lys Glu Arg Pro Leu Ala Thr Phe Tyr Ile Glu Glu Thr 
945                 950                 955                 960 


Glu Thr Lys Val Leu Lys Gln Gly Asn Phe Lys Val Leu Ala Lys Asp 
                965                 970                 975     


Arg Arg Leu Asn Gly Leu Leu Ser Phe Ala Glu Thr Thr Asp Ile Asp 
            980                 985                 990         


Leu Glu Lys Asn Pro Ile Thr Lys  Leu Ser Val Asp His  Glu Leu Ile 
        995                 1000                 1005             


Lys Tyr  Gln Thr Thr Arg Ile  Ser Ile Phe Glu Met  Thr Leu Gly 
    1010                 1015                 1020             


Leu Glu  Lys Lys Leu Ile Asp  Lys Tyr Ser Thr Leu  Pro Thr Asp 
    1025                 1030                 1035             


Ser Phe  Arg Asn Met Leu Gly  Ser Trp Leu Glu Asp  Lys Thr Asn 
    1040                 1045                 1050             


Ser Ala  Glu Leu Asn Asn Tyr  Val Asp Cys Leu Ile  Thr Val Arg 
    1055                 1060                 1065             


Asn Ala  Phe Ala His Asn Gln  Tyr Pro Met Tyr Asn  Pro Lys Leu 
    1070                 1075                 1080             


Phe Ala  Glu Val Lys Lys Phe  Ser Leu Phe Pro Ser  Ser Asn Thr 
    1085                 1090                 1095             


Lys Lys  Thr Glu Leu Asn Ile  Ala Ser Gln Leu Leu  Arg Ile Val 
    1100                 1105                 1110             


Glu Lys  Ala Ile Asp Glu Ile  Glu Lys Ser Glu Asn  Lys Asn 
    1115                 1120                 1125         


<210>  2448
<211>  1123
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2448

Met Lys Glu Glu Glu Thr Pro Val Val Ser Thr Tyr Asn Lys Asp Asp 
1               5                   10                  15      


Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val Tyr 
            20                  25                  30          


Ile Thr Ile Asn His Ile Asn Lys Leu Leu Glu Ile Arg Glu Ile Asp 
        35                  40                  45              


Asn Asp Glu Lys Val Leu Asp Ile Lys Ala Leu Trp Gln Lys Val Asn 
    50                  55                  60                  


Lys Asp Leu Asn Gln Lys Ala Arg Leu Arg Glu Leu Met Thr Lys His 
65                  70                  75                  80  


Phe Pro Phe Leu Glu Thr Ala Ile Tyr Thr Lys Asn Lys Glu Asp Lys 
                85                  90                  95      


Lys Glu Val Lys Gln Glu Lys Gln Ala Glu Ala Gln Ser Leu Glu Ser 
            100                 105                 110         


Leu Lys Asp Cys Leu Phe Leu Phe Leu Glu Lys Leu Gln Glu Ala Arg 
        115                 120                 125             


Asn Tyr Tyr Ser His Tyr Lys Tyr Ser Glu Ser Thr Lys Glu Pro Met 
    130                 135                 140                 


Leu Glu Glu Gly Leu Leu Glu Lys Met Tyr Asn Ile Phe Asp Asp Asn 
145                 150                 155                 160 


Ile Gln Leu Val Ile Lys Asp Tyr Gln His Asn Lys Asp Ile Asn Pro 
                165                 170                 175     


Asp Glu Asp Phe Lys His Leu Asp Arg Lys Gly Gln Phe Lys Tyr Ser 
            180                 185                 190         


Phe Ala Asp Asn Glu Gly Asn Ile Thr Glu Ser Gly Leu Leu Phe Phe 
        195                 200                 205             


Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Met Gln Gln Lys 
    210                 215                 220                 


Phe Thr Gly Phe Lys Asp Asn Arg Glu Asn Asn Lys Gln Met Thr His 
225                 230                 235                 240 


Glu Val Phe Cys Arg Ser Arg Ile Leu Met Pro Lys Leu Arg Leu Glu 
                245                 250                 255     


Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu Asn Glu Leu 
            260                 265                 270         


Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Lys Gly Glu Asp Arg 
        275                 280                 285             


Lys Lys Phe Glu Val Pro Phe Asp Ser Thr Asp Glu Asp Tyr Asp Ala 
    290                 295                 300                 


Glu Gln Asp Pro Phe Lys Asn Thr Leu Ile Arg His Gln Asp Arg Phe 
305                 310                 315                 320 


Pro Tyr Phe Val Leu Arg Tyr Phe Asp Tyr Asn Glu Ile Phe Lys Asn 
                325                 330                 335     


Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile Tyr Lys 
            340                 345                 350         


Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg His Leu Thr His Lys Leu 
        355                 360                 365             


Tyr Gly Phe Glu Arg Ile Gln Glu Phe Thr Lys Gln His Arg Pro Asp 
    370                 375                 380                 


Asp Trp Lys Ala Ile Val Lys Asp Phe Asp Thr Tyr Glu Thr Ser Glu 
385                 390                 395                 400 


Glu Pro Tyr Ile Ser Glu Thr Thr Pro His Tyr His Leu Glu Asn Gln 
                405                 410                 415     


Lys Ile Gly Ile Arg Phe Lys Asn Asp Asn Asp Lys Ile Trp Pro Ser 
            420                 425                 430         


Leu Glu Thr Asn Gly Glu Asn Asn Glu Lys Ser Lys Tyr Lys Leu Asp 
        435                 440                 445             


Lys Gln Tyr Gln Ala Glu Ala Phe Met Ser Ile His Glu Leu Leu Pro 
    450                 455                 460                 


Met Met Phe Tyr Tyr Leu Leu Leu Lys Lys Glu Glu Pro Asn Asn Asp 
465                 470                 475                 480 


Lys Lys Asn Ala Ser Arg Val Glu Gly Phe Ile Lys Arg Glu Ile Arg 
                485                 490                 495     


Asp Ile Phe Lys Leu Tyr Asp Ala Phe Ala Asn Asp Glu Ile Asn Asn 
            500                 505                 510         


Ile Asp Asp Leu Lys Lys Tyr Tyr Lys Asp Lys Asn Val Glu Ile Arg 
        515                 520                 525             


His Leu Pro Lys Gln Met Ile Ala Ile Leu Glu Ser Lys Pro Lys Asp 
    530                 535                 540                 


Met Ala Lys Glu Ala Lys Arg Lys Gln Lys Glu Met Val Lys Asp Thr 
545                 550                 555                 560 


Lys Lys Leu Leu Ala Thr Leu Glu Lys Gln Thr Gln Lys Glu Lys Glu 
                565                 570                 575     


Asp Asp Gly Arg Asn Val Lys Leu Leu Lys Ser Gly Glu Ile Ala Arg 
            580                 585                 590         


Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln Lys Asp Asn 
        595                 600                 605             


Glu Gly Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln 
    610                 615                 620                 


Met Leu Gln Arg Ser Leu Ala Leu Tyr Asn Lys Glu Glu Lys Pro Thr 
625                 630                 635                 640 


Arg Tyr Phe Arg Gln Val Asn Leu Ile Glu Ser Ser Asn Pro His Pro 
                645                 650                 655     


Phe Leu Lys Trp Thr Lys Trp Glu Glu Cys Asn Asn Ile Leu Thr Phe 
            660                 665                 670         


Tyr His Arg Tyr Leu Thr Lys Lys Ile Glu Phe Leu Asn Lys Leu Lys 
        675                 680                 685             


Pro Glu Asp Trp Lys Lys Asn Gln Tyr Phe Leu Lys Val Lys Glu Pro 
    690                 695                 700                 


Lys Thr Asn Arg Glu Thr Leu Val Gln Gly Trp Lys Asn Gly Phe Asn 
705                 710                 715                 720 


Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg Glu Trp Phe Glu Arg 
                725                 730                 735     


His Gln Asn Asp Ser Glu Glu Tyr Lys Lys Val Glu Lys Leu Asn Lys 
            740                 745                 750         


Ala Gly Leu Val Thr Lys Val Ile Pro Leu Phe Phe Lys Glu Glu Ser 
        755                 760                 765             


Phe Lys Asn Lys Glu Glu His Phe Lys Glu Asp Thr Gln Lys Glu Ile 
    770                 775                 780                 


Asn Asp Cys Val Gln Pro Phe Tyr Asn Phe Pro Tyr Asn Val Gly Asn 
785                 790                 795                 800 


Ile Tyr Arg Leu Lys Asp Glu Asp Phe Leu His Arg Glu Glu Arg Ile 
                805                 810                 815     


Lys Leu Trp Asn Asn Lys Lys Asp Lys Phe Lys Gly Tyr Lys Glu Lys 
            820                 825                 830         


Ile Lys Ser Lys Lys Leu Thr Glu Lys Glu Lys Glu Glu Phe Arg Ser 
        835                 840                 845             


Tyr Leu Glu Phe Gln Ser Trp Asn Asn Phe Glu Arg Glu Leu Arg Leu 
    850                 855                 860                 


Val Arg Asn Gln Asp Ile Val Thr Trp Leu Leu Cys Lys Glu Leu Ile 
865                 870                 875                 880 


Asp Lys Leu Lys Ile Asp Glu Leu Asn Ile Glu Glu Leu Lys Lys Leu 
                885                 890                 895     


Arg Leu Asn Asn Ile Asp Thr Asp Thr Ala Lys Lys Glu Lys Asn Asn 
            900                 905                 910         


Ile Leu Asn Arg Val Met Pro Met Glu Leu Pro Val Met Val Tyr Glu 
        915                 920                 925             


Val Asn Lys Ala Gly Asn Ile Ile Lys Asn Lys Pro Leu His Thr Ile 
    930                 935                 940                 


Tyr Ile Lys Glu Ala Lys Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys 
945                 950                 955                 960 


Ala Leu Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Val Lys 
                965                 970                 975     


Thr Asn Ser Glu Ala Glu Ser Lys Arg Asn Pro Ile Ser Lys Leu Leu 
            980                 985                 990         


Val Glu Tyr Glu Leu Gly Glu Tyr  Gln Glu Ala Arg Ile  Glu Ile Ile 
        995                 1000                 1005             


Lys Asp  Met Leu Ala Leu Glu  Glu Thr Leu Ile Asn  Lys Tyr Lys 
    1010                 1015                 1020             


Asp Leu  Pro Thr Asn Lys Phe  Ser Asp Met Leu Asn  Ser Trp Leu 
    1025                 1030                 1035             


Glu Gly  Lys Asp Glu Ala Asp  Lys Ala Arg Phe Gln  Asn Asp Val 
    1040                 1045                 1050             


Asp Phe  Leu Ile Ala Val Arg  Asn Ala Phe Ser His  Asn Gln Tyr 
    1055                 1060                 1065             


Pro Met  Arg Asn Arg Ile Ala  Phe Ala Asn Ile Asn  Pro Phe Ser 
    1070                 1075                 1080             


Leu Ser  Ser Ala Asp Ile Ser  Glu Glu Lys Gly Leu  Asn Ile Ala 
    1085                 1090                 1095             


Asn Gln  Leu Lys Asp Lys Thr  Lys Glu Thr Ile Asp  Lys Ile Ile 
    1100                 1105                 1110             


Glu Ile  Glu Lys Pro Ile Glu  Thr Lys Glu 
    1115                 1120             


<210>  2449
<211>  1091
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2449

Met Lys Glu Glu Glu Lys Gly Lys Thr Pro Val Val Ser Thr Tyr Asn 
1               5                   10                  15      


Lys Asp Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His 
            20                  25                  30          


Asn Val Tyr Ile Thr Val Asn His Ile Asn Lys Ile Leu Gly Glu Ala 
        35                  40                  45              


Glu Ile Asn Ile Asp Gly Tyr Asp Ile Ser Leu Lys Asn Ile Trp Ser 
    50                  55                  60                  


Gly Ile Arg Asp Ile Asn Lys Lys Ala Arg Leu Glu Glu Leu Met Ile 
65                  70                  75                  80  


Lys His Phe Pro Phe Leu Glu Ala Met Thr His Gln Gln Arg Leu Thr 
                85                  90                  95      


Gly Asn Thr Lys Gln Lys Glu Glu Lys Gln Ala Lys Ile Gln Ser Phe 
            100                 105                 110         


Glu Ile Leu Lys Asp Asn Leu Phe Leu Leu Leu Lys Met Leu Gln Asp 
        115                 120                 125             


Leu Arg Asn His Tyr Ser His Tyr Lys His Ser Lys Ser Leu Glu Arg 
    130                 135                 140                 


Pro Lys Phe Asp Glu Asp Ile Arg Asn Lys Leu Tyr Asn Ile Phe Asp 
145                 150                 155                 160 


Thr Ser Ile Arg Leu Val Lys Glu Asp Tyr Lys His Asn Pro Asp Ile 
                165                 170                 175     


Lys Pro Lys Glu His Phe Lys His Leu Asp Arg Lys Arg Asn Glu Lys 
            180                 185                 190         


Phe Arg Tyr Ser Phe Ala Asp Asn Glu Gly Asn Ile Thr Ile Ser Gly 
        195                 200                 205             


Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp 
    210                 215                 220                 


Val Gln Lys Lys Leu Glu Gly Phe Arg Cys Ser Asn Glu Ser Tyr Gln 
225                 230                 235                 240 


Lys Met Thr Asn Glu Val Phe Cys Arg Asn Arg Ile Leu Met Pro Lys 
                245                 250                 255     


Leu Arg Leu Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met 
            260                 265                 270         


Leu Asn Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Lys 
        275                 280                 285             


Gly Glu Asp Arg Lys Lys Phe Glu Val Pro Phe Asp Ser Thr Asp Glu 
    290                 295                 300                 


Asp Tyr Asp Ala Glu Gln Asp Pro Phe Lys Asn Thr Leu Ile Arg Tyr 
305                 310                 315                 320 


Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe Asp Tyr Asn Glu 
                325                 330                 335     


Ile Phe Glu Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe 
            340                 345                 350         


Ser Ile Tyr Lys Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg His Leu 
        355                 360                 365             


Thr His Lys Leu Tyr Gly Phe Glu Arg Leu Gln Glu Phe Ala Lys Gln 
    370                 375                 380                 


Asn Arg Pro Asp Glu Trp Lys Ala Ile Ile Lys Asp Leu Asp Thr Phe 
385                 390                 395                 400 


Lys Lys Gln Glu Asp Glu Lys Val Asn Glu Lys Pro Tyr Ile Ser Glu 
                405                 410                 415     


Thr Thr Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Ala Phe 
            420                 425                 430         


Lys Asn His Asn Ile Trp Pro Thr Thr Asn Thr Glu Phe Thr Asn Asn 
        435                 440                 445             


Lys Arg Lys Lys Tyr Asn Leu Gly Thr Ser Ile Lys Ala Glu Ala Phe 
    450                 455                 460                 


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Met Leu Leu 
465                 470                 475                 480 


Lys Ile Lys Asn Glu Gly Pro Arg Lys Val Glu Ala Ile Ile Glu Ser 
                485                 490                 495     


Lys Ile Lys Asp Ile Phe Thr Leu Tyr Asp Ala Phe Ala Asn Asp Glu 
            500                 505                 510         


Ile Asp Asn Thr Asp Glu Leu Glu Lys Tyr Cys Glu Asp Lys Asp Ile 
        515                 520                 525             


Lys Ile Gly His Leu Pro Lys Gln Met Ile Ala Ile Leu Tyr Asn Lys 
    530                 535                 540                 


His Lys Asp Met Val Glu Lys Ala Lys Val Lys Gln Glu Lys Met Lys 
545                 550                 555                 560 


Leu Ala Thr Glu Asn Arg Leu Lys Thr Leu Asp Lys Leu Ile Glu Gly 
                565                 570                 575     


Lys Met Lys Tyr Ala Lys Arg Gly Ile Ser Pro Leu Lys Ser Gly Glu 
            580                 585                 590         


Ile Ala Ser Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln 
        595                 600                 605             


Arg Asp Glu Asn Gly Glu Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr 
    610                 615                 620                 


Glu Tyr Gln Leu Leu Gln Arg Thr Leu Ala Leu Phe Gly Ser Glu His 
625                 630                 635                 640 


Lys Arg Leu Thr Pro Tyr Phe Lys Gln Met Asn Leu Ile Gly Asp Asn 
                645                 650                 655     


Asn Ser His Pro Phe Leu Lys Gln Thr Glu Trp Glu Glu Cys Asn Asn 
            660                 665                 670         


Ile Leu Ser Phe Tyr Arg Ser Tyr Leu Glu Ala Arg Lys Asn Phe Leu 
        675                 680                 685             


Lys Asn Leu Glu Pro Lys Asp Trp Lys Lys Asn Gln Tyr Phe Leu Lys 
    690                 695                 700                 


Ile Lys Glu Pro Lys Ser Asn Arg Gln Thr Leu Val Gln Gly Trp Lys 
705                 710                 715                 720 


Asn Gly Phe Asn Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Lys Lys 
                725                 730                 735     


Trp Phe Ile Glu His Arg Lys Lys Met Lys Val Asp Glu Leu Lys Ser 
            740                 745                 750         


Val Gly Leu Val Ala Lys Val Ile Pro Leu Tyr Phe Asn Glu Lys Tyr 
        755                 760                 765             


Lys Asp Ser Val Gln Pro Phe Tyr Asn Tyr Pro Phe Asn Val Gly Asp 
    770                 775                 780                 


Ile Asn Lys Pro Lys Glu Lys Asp Phe Leu Asp Asn Gly Lys Arg Arg 
785                 790                 795                 800 


Lys Leu Trp Asp Lys Lys Gln Leu Glu Phe Lys Gly Lys Thr Glu Glu 
                805                 810                 815     


Glu Lys Arg Lys Asn Pro Ser Tyr Leu Asp Phe Lys Ser Trp Lys Lys 
            820                 825                 830         


Phe Glu Arg Glu Leu Arg Leu Ile Arg Asn Gln Asp Ile Val Thr Trp 
        835                 840                 845             


Leu Met Cys Ile Glu Leu Tyr Asn Asn Gln Lys Val Glu Asn Leu Asn 
    850                 855                 860                 


Thr Gly His Ile Tyr Leu Lys Asp Ile Ile Thr Asn Val Lys Glu Glu 
865                 870                 875                 880 


Arg Asn Asn Asn Ile Leu Asn Gln Ile Lys Ser Met Gln Leu Pro Val 
                885                 890                 895     


Thr Val Tyr Glu Asn Glu Ser Ser Pro Lys Lys Lys Tyr Leu Arg Thr 
            900                 905                 910         


Ile Tyr Ile Glu Glu Asn Gly Thr Lys Leu Leu Lys Gln Gly Asn Phe 
        915                 920                 925             


Lys Ala Leu Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Val 
    930                 935                 940                 


Lys Thr Ser Ser Glu Ala Glu Ser Lys Arg Asn Pro Ile Ser Lys Leu 
945                 950                 955                 960 


Arg Val Glu His Glu Leu Arg Glu Tyr Gln Lys Ala Arg Ile Asp Ile 
                965                 970                 975     


Ile Lys Asp Met Leu Ala Leu Glu Lys Thr Leu Ile Asp Asn Tyr Asp 
            980                 985                 990         


Ser Leu Asp Thr Asp Asn Phe His  Asn Met Leu Thr Gly  Trp Leu Glu 
        995                 1000                 1005             


Leu Lys  Gly Glu Ala Ile Lys  Thr Lys Phe Asn Asn  Asp Val Lys 
    1010                 1015                 1020             


Leu Leu  Thr Ala Val Arg Asn  Ala Phe Ser His Asn  Gln Tyr Pro 
    1025                 1030                 1035             


Met Tyr  Asp Glu Asn Leu Phe  Ile Asn Ile Glu Arg  Phe Ser Leu 
    1040                 1045                 1050             


Ser Ser  Ser Arg Ile Leu Glu  Ser Lys Gly Leu Gly  Ile Ala Val 
    1055                 1060                 1065             


Lys Leu  Lys Glu Glu Val Ser  Asn Ala Ile Glu Lys  Ile Lys Asn 
    1070                 1075                 1080             


Glu Glu  Asp Ala Lys Lys Glu  Thr 
    1085                 1090     


<210>  2450
<211>  1147
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2450

Met Glu Ile Ala Thr Gln Gln Ser Glu Thr Gln Lys Lys Lys Arg Ser 
1               5                   10                  15      


Leu Asp Gln Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg 
            20                  25                  30          


His Asn Val Phe Leu Ile Val Asn His Leu Thr Asp Thr Phe Lys Glu 
        35                  40                  45              


Leu Asn Phe Lys Lys Leu Ala Asn Glu Glu Asp Ile Trp Lys Val Asp 
    50                  55                  60                  


Asn Ser Ser Asn Ile Leu Leu Asn Val Phe Asp Val Thr Gln Ser Lys 
65                  70                  75                  80  


Tyr Glu Asp Phe Arg Pro Arg Ile Phe His Tyr Leu Ile Lys Arg His 
                85                  90                  95      


His Leu Pro Leu Val Lys Ile Phe Asn Thr Glu Tyr Leu Gly Glu Asn 
            100                 105                 110         


Ile Leu Gln Asp Lys Ser Ile Asp Tyr Glu Arg Leu His Gln Phe Leu 
        115                 120                 125             


Cys Leu Ser Phe Lys Glu Leu Thr Glu Phe Arg Asn Ser Tyr Ser His 
    130                 135                 140                 


Ser Ile Ala Ile Asp Glu Asn Gly Asn Lys Val Gly Arg Lys Thr Thr 
145                 150                 155                 160 


Leu Ala Asn Asp Leu Val Pro Glu Val Asn Leu Leu Phe Lys Tyr Ala 
                165                 170                 175     


Pro Lys Tyr Ser Phe Leu Arg Asn His Gln Thr Leu Asn Glu Gly Asp 
            180                 185                 190         


Phe Gln His Leu Asp Asn Tyr Gln Leu Phe Ile Ala Asp Asn Gln Leu 
        195                 200                 205             


Thr His Gln Gly Arg Phe Phe Phe Ile Asn Leu Phe Leu Glu Arg Ser 
    210                 215                 220                 


Tyr Gly Ile Lys Phe Leu Lys Arg Phe Arg Gly Phe Lys Asn Glu Asn 
225                 230                 235                 240 


Thr Pro Pro Phe Lys Ala Thr Ile Gln Ser Phe Thr Thr Tyr Cys Leu 
                245                 250                 255     


Lys Val Pro Asp Ile Arg Leu Gly Asn Glu Asn Pro Lys Gln Ser Leu 
            260                 265                 270         


Leu Leu Asp Met Leu Thr Glu Leu Asn Lys Cys Pro Lys Glu Leu Phe 
        275                 280                 285             


Asn His Leu Thr Glu Asp Asp Lys Lys Glu Phe Glu Pro Asn Leu Asp 
    290                 295                 300                 


Glu Thr Ser Ser Thr Asn Val Leu Leu Asn Ser Thr Asn Tyr Glu Phe 
305                 310                 315                 320 


Phe Asp Thr Asp Glu Val Glu Glu Ala Ile Arg Glu Leu Thr Ala Gln 
                325                 330                 335     


Lys Arg His Ser Asp Arg Phe Pro Tyr Leu Ala Leu Arg Phe Leu Asp 
            340                 345                 350         


Glu Thr Met Ala Phe Ser Gln Leu Arg Phe Gln Leu Ser Leu Gly Lys 
        355                 360                 365             


Ile Ile Ile Lys Lys Pro Tyr Gln Lys Thr Ile Leu Gly Gln Pro Asn 
    370                 375                 380                 


Asp Arg Ile Ile Thr Lys Lys Leu Asn Val Phe Gly Arg Ile Ser Asp 
385                 390                 395                 400 


Phe Leu Asn Arg Glu Lys Glu Ile Ile Arg Ala Leu Ser Asn Asp Gln 
                405                 410                 415     


Asn Val Asp Phe Leu Glu Phe Glu Gln Phe Phe Pro His Tyr Asn Ile 
            420                 425                 430         


Asn Asn Asn Lys Ile Ala Phe Tyr Phe Leu Asn Asp Ser Asp Leu Thr 
        435                 440                 445             


Glu Glu Asn Leu Glu Ser Arg Leu Arg Asp Gln Glu Asn Arg Gln Pro 
    450                 455                 460                 


Thr Gly Phe Leu Ser Ile His Asp Leu Pro Lys Leu Val Leu Leu His 
465                 470                 475                 480 


Leu Leu Ala Pro Ser Glu Val Gln Lys Thr Leu Gln Arg Phe Ile Asn 
                485                 490                 495     


Asp Asn Asn Pro Ala Phe Phe Asp Leu Glu Leu Leu Ala Asn Ile Lys 
            500                 505                 510         


Ser Lys Val Val Tyr Glu Pro Ser Thr Phe Thr Lys Arg Ser Glu His 
        515                 520                 525             


Gln Tyr Arg Asp Ala Asp Lys Gln Glu Glu Glu Thr Glu Lys Gln Gln 
    530                 535                 540                 


Glu Tyr Gln Thr Leu Leu Asn Gln Arg Lys Arg Leu Leu Glu Gln His 
545                 550                 555                 560 


Leu Pro Lys Gly Val Lys Ile Asn Gln Ile Pro Glu Lys Val Leu Asp 
                565                 570                 575     


Phe Leu Met Asn Ile Ser Glu Pro Asn Glu Asn Lys Val Ile His Gln 
            580                 585                 590         


Lys Ile Lys Ser Ile Lys Asp Glu Ala Lys Thr Leu Leu Gln Arg Val 
        595                 600                 605             


Lys Asn Lys Gln Ala Ala Asn Glu Ile Pro Lys Leu Gly Glu Leu Ala 
    610                 615                 620                 


Thr Phe Leu Thr Arg Asp Ile Ile Asn Met Val Val Ser Glu Glu Leu 
625                 630                 635                 640 


Lys Lys Lys Ile Thr Ser Pro Tyr Ser Asn Lys Leu Gln Asn Lys Ile 
                645                 650                 655     


Ala Phe Phe Ser Leu Ser Lys Gln Glu Ile Ile Ser Leu Leu Ser Glu 
            660                 665                 670         


Leu Gln Leu Leu Asn Asn Glu Lys Gly His Val Phe Leu Ser Ser Arg 
        675                 680                 685             


Leu Ile Leu Glu Ser Asn Gly Leu Leu Ser Phe Tyr Lys Ser Tyr Leu 
    690                 695                 700                 


Glu Ala Lys Ile Ala Trp Ile Asp Lys Asn Leu Phe Leu Lys Gly Lys 
705                 710                 715                 720 


Lys Gly Gly Tyr Ile Ile Pro Glu Asn Lys Pro Val Pro Lys Thr Leu 
                725                 730                 735     


Gln Lys Ile Lys Gln Glu Val Ser Gln Phe Asp Phe Thr Gln Trp Leu 
            740                 745                 750         


Gln Asn Lys Ala Ala Met Pro Ile Asp Val Pro Asn Thr Ile Phe Asp 
        755                 760                 765             


Val Ser Leu Glu Asn Leu Leu Lys Thr Asn Leu Lys Lys Arg Gly Ile 
    770                 775                 780                 


Thr Val Lys Asp Thr Asp Lys Phe Ser Val Leu Leu Asn Lys Tyr Leu 
785                 790                 795                 800 


Asp Lys Asp Thr Gln Pro Phe Tyr Lys Tyr Gly Arg Val Tyr Lys Ile 
                805                 810                 815     


Gln Asp Glu Glu Glu Ser Val Gln Val Val Gly Lys Met Ser Lys Thr 
            820                 825                 830         


Leu Lys Lys Gln Tyr Gly Lys Phe Val Glu Glu Asn Glu Lys Val Ile 
        835                 840                 845             


Arg Phe Tyr Gln Ser Lys Asp Arg Val Ile Lys Leu Met Cys Asn Ala 
    850                 855                 860                 


Leu Leu Gln Ala Glu Asn Lys Thr Ala Leu Thr Asp Ser Phe Lys Leu 
865                 870                 875                 880 


Ala His Thr His Pro Asn Ser Lys Gln Asn Pro Leu Asp Thr Pro Met 
                885                 890                 895     


Arg Phe Glu Gln Lys Leu Phe Ser Asn Asp Lys Glu Thr Lys Val Leu 
            900                 905                 910         


Cys Thr Ile Tyr Ala Gln Asp Thr Glu Asn Gln Lys Asn Glu Ile Leu 
        915                 920                 925             


Ala Trp Asn Ser Leu Ser Glu Asp Asp Lys Lys Tyr Trp Leu Thr Leu 
    930                 935                 940                 


Thr Thr Lys Glu Ala Gln Lys Glu Trp Leu Ser Gly Lys Pro Glu Thr 
945                 950                 955                 960 


Glu Gln Glu Val Tyr His Gly Gln Lys Gly Tyr Gln Trp Thr Ile Lys 
                965                 970                 975     


Glu Val Gly Lys Phe Lys Arg Phe Val Lys Asp Arg Arg Ile Pro Ala 
            980                 985                 990         


Leu Val Asn Tyr Phe Glu Thr Thr  Lys Leu Pro Phe Ser  Leu Leu Glu 
        995                 1000                 1005             


Tyr Gln  Leu Lys Glu Tyr Asp  Arg Val Arg Glu Gln  Ile Phe Asp 
    1010                 1015                 1020             


Gly Val  Phe Lys Leu Glu Glu  Ala Ile Ser Gln Lys  Asp Leu Ala 
    1025                 1030                 1035             


Gly Ile  Trp Ala Leu Glu Gln  Glu Ala Arg Gly Arg  Lys Asn Tyr 
    1040                 1045                 1050             


His Gln  Val Gln Phe Asn Ile  Phe Glu Lys Tyr Leu  Gln Asn Thr 
    1055                 1060                 1065             


Leu Pro  Ser Tyr Asp Pro Ala  Ile Gly Val Ile Arg  Asn Lys Phe 
    1070                 1075                 1080             


Ser His  Asn Glu Phe Pro Asp  Leu Ile Gly Gln Gly  Ile Glu Lys 
    1085                 1090                 1095             


Ile Ser  Gln Ala Gln Ile Asp  Asp Tyr Gln Arg Asn  Lys His Leu 
    1100                 1105                 1110             


Lys Asp  Tyr Leu Ala His Ala  Gly Ile Ser Ile Ala  Gln Gln Ile 
    1115                 1120                 1125             


Leu Ala  Ile Phe Glu Gln Lys  Ile Asn Asp Thr Leu  Thr Gln Leu 
    1130                 1135                 1140             


Thr Thr  His Gly 
    1145         


<210>  2451
<211>  1147
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2451

Met Glu Ile Ala Thr Gln Gln Ser Glu Thr Gln Lys Lys Lys Arg Ser 
1               5                   10                  15      


Leu Asp Gln Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg 
            20                  25                  30          


His Asn Val Phe Leu Ile Val Asn His Leu Thr Asp Thr Phe Lys Glu 
        35                  40                  45              


Leu Asn Phe Lys Lys Leu Ala Asn Glu Glu Asp Ile Trp Lys Val Asp 
    50                  55                  60                  


Asn Ser Ser Asn Ile Leu Leu Asn Val Phe Asp Val Thr Gln Ser Lys 
65                  70                  75                  80  


Tyr Glu Asp Phe Arg Pro Arg Ile Phe His Tyr Leu Ile Lys Arg His 
                85                  90                  95      


His Leu Pro Leu Val Lys Ile Phe Asn Thr Glu Tyr Leu Gly Glu Asn 
            100                 105                 110         


Ile Leu Gln Asp Lys Ser Ile Asp Tyr Glu Arg Leu His Gln Phe Leu 
        115                 120                 125             


Cys Leu Ser Phe Lys Glu Leu Thr Glu Phe Arg Asn Ser Tyr Ser His 
    130                 135                 140                 


Ser Ile Ala Ile Asp Glu Asn Gly Asn Lys Val Gly Arg Lys Thr Thr 
145                 150                 155                 160 


Leu Ala Asn Asp Leu Val Pro Glu Val Asn Leu Leu Phe Lys Tyr Ala 
                165                 170                 175     


Pro Lys Tyr Ser Phe Leu Arg Asn His Gln Thr Leu Asn Glu Gly Asp 
            180                 185                 190         


Phe Gln His Leu Asp Asn Tyr Gln Leu Phe Ile Ala Asp Asn Gln Leu 
        195                 200                 205             


Thr His Gln Gly Arg Phe Phe Phe Ile Asn Leu Phe Leu Glu Arg Ser 
    210                 215                 220                 


Tyr Gly Ile Lys Phe Leu Lys Arg Phe Arg Gly Phe Lys Asn Glu Asn 
225                 230                 235                 240 


Thr Pro Pro Phe Lys Ala Thr Ile Gln Ser Phe Thr Thr Tyr Cys Leu 
                245                 250                 255     


Lys Val Pro Asp Ile Arg Leu Gly Asn Glu Asn Pro Lys Gln Ser Leu 
            260                 265                 270         


Leu Leu Asp Met Leu Thr Glu Leu Asn Lys Cys Pro Lys Glu Leu Phe 
        275                 280                 285             


Asn His Leu Thr Glu Asp Asp Lys Lys Glu Phe Glu Pro Asn Leu Asp 
    290                 295                 300                 


Glu Thr Ser Ser Thr Asn Val Leu Leu Asn Ser Thr Asn Tyr Glu Phe 
305                 310                 315                 320 


Phe Asp Thr Asp Glu Val Glu Glu Ala Ile Arg Glu Leu Thr Ala Gln 
                325                 330                 335     


Lys Arg His Ser Asp Arg Phe Pro Tyr Leu Ala Leu Arg Phe Leu Asp 
            340                 345                 350         


Glu Thr Met Ala Phe Ser Gln Leu Arg Phe Gln Leu Ser Leu Gly Lys 
        355                 360                 365             


Ile Ile Ile Lys Lys Pro Tyr Gln Lys Thr Ile Leu Gly Gln Pro Asn 
    370                 375                 380                 


Asp Arg Ile Ile Thr Lys Lys Leu Asn Val Phe Gly Arg Ile Ser Asp 
385                 390                 395                 400 


Phe Leu Asn Arg Glu Lys Glu Ile Ile Arg Ala Leu Ser Asn Asp Gln 
                405                 410                 415     


Asn Val Asp Phe Leu Glu Phe Glu Gln Phe Phe Pro His Tyr Asn Ile 
            420                 425                 430         


Asn Asn Asn Lys Ile Ala Phe Tyr Phe Leu Asn Asp Ser Asp Leu Thr 
        435                 440                 445             


Glu Glu Asn Leu Glu Ser Arg Leu Arg Asp Gln Glu Asn Arg Gln Pro 
    450                 455                 460                 


Thr Gly Phe Leu Ser Ile His Asp Leu Pro Lys Leu Val Leu Leu His 
465                 470                 475                 480 


Leu Leu Ala Pro Ser Glu Val Gln Lys Thr Leu Gln Arg Phe Ile Asn 
                485                 490                 495     


Asp Asn Asn Pro Ala Phe Phe Asp Leu Glu Leu Leu Ala Asn Ile Lys 
            500                 505                 510         


Ser Lys Val Val Tyr Glu Pro Ser Thr Phe Thr Lys Arg Ser Glu His 
        515                 520                 525             


Gln Tyr Arg Asp Ala Asp Lys Gln Glu Glu Glu Thr Glu Lys Gln Gln 
    530                 535                 540                 


Glu Tyr Gln Thr Leu Leu Asn Gln Arg Lys Arg Leu Leu Glu Gln His 
545                 550                 555                 560 


Leu Pro Lys Gly Val Lys Ile Asn Gln Ile Pro Glu Lys Val Leu Asp 
                565                 570                 575     


Phe Leu Met Asn Ile Ser Glu Pro Asn Glu Asn Lys Val Ile His Gln 
            580                 585                 590         


Lys Ile Lys Ser Ile Lys Asp Glu Ala Lys Thr Leu Leu Gln Arg Val 
        595                 600                 605             


Lys Asn Lys Gln Ala Ala Asn Glu Ile Pro Lys Leu Gly Glu Leu Ala 
    610                 615                 620                 


Thr Phe Leu Thr Arg Asp Ile Ile Asn Met Val Val Ser Glu Glu Leu 
625                 630                 635                 640 


Lys Lys Lys Ile Thr Ser Pro Tyr Ser Asn Lys Leu Gln Asn Lys Ile 
                645                 650                 655     


Ala Phe Phe Ser Leu Ser Lys Gln Glu Ile Ile Ser Leu Leu Ser Glu 
            660                 665                 670         


Leu Gln Leu Leu Asn Asn Glu Lys Gly His Val Phe Leu Ser Ser Arg 
        675                 680                 685             


Leu Ile Leu Glu Ser Asn Gly Leu Leu Ser Phe Tyr Lys Ser Tyr Leu 
    690                 695                 700                 


Glu Ala Lys Ile Ala Trp Ile Asp Lys Asn Leu Phe Leu Lys Gly Lys 
705                 710                 715                 720 


Lys Gly Gly Tyr Ile Ile Pro Glu Asn Lys Pro Val Pro Lys Thr Leu 
                725                 730                 735     


Gln Lys Ile Lys Gln Glu Val Ser Gln Phe Asp Phe Thr Gln Trp Leu 
            740                 745                 750         


Gln Asn Lys Ala Ala Met Pro Ile Asp Val Pro Asn Thr Ile Phe Asp 
        755                 760                 765             


Val Ser Leu Glu Asn Leu Leu Lys Thr Asn Leu Lys Lys Arg Gly Ile 
    770                 775                 780                 


Thr Val Lys Asp Thr Asp Lys Phe Ser Val Leu Leu Asn Lys Tyr Leu 
785                 790                 795                 800 


Asp Lys Asp Thr Gln Pro Phe Tyr Lys Tyr Gly Arg Val Tyr Lys Ile 
                805                 810                 815     


Gln Asp Glu Glu Glu Ser Val Gln Val Val Gly Lys Met Ser Lys Thr 
            820                 825                 830         


Leu Lys Lys Gln Tyr Gly Lys Phe Val Glu Glu Asn Glu Lys Val Ile 
        835                 840                 845             


Arg Phe Tyr Gln Ser Lys Asp Arg Val Ile Lys Leu Met Cys Asn Ala 
    850                 855                 860                 


Leu Leu Gln Ala Glu Asn Lys Thr Ala Leu Thr Asp Ser Phe Lys Leu 
865                 870                 875                 880 


Ala His Thr His Pro Asn Ser Lys Gln Asn Pro Leu Asp Thr Pro Met 
                885                 890                 895     


Arg Phe Glu Gln Lys Leu Phe Ser Asn Asp Lys Glu Thr Lys Val Leu 
            900                 905                 910         


Cys Thr Ile Tyr Ala Gln Asp Thr Glu Asn Gln Lys Asn Glu Ile Leu 
        915                 920                 925             


Ala Trp Asn Ser Leu Ser Glu Asp Asp Lys Lys Tyr Trp Leu Thr Leu 
    930                 935                 940                 


Thr Thr Lys Glu Ala Gln Lys Glu Trp Leu Ser Gly Lys Pro Glu Thr 
945                 950                 955                 960 


Glu Gln Glu Val Tyr His Gly Gln Lys Gly Tyr Gln Trp Thr Ile Lys 
                965                 970                 975     


Glu Val Gly Lys Phe Lys Arg Phe Val Lys Asp Arg Arg Ile Pro Ala 
            980                 985                 990         


Leu Val Asn Tyr Phe Glu Thr Thr  Lys Leu Pro Phe Ser  Leu Leu Glu 
        995                 1000                 1005             


Tyr Gln  Leu Lys Glu Tyr Asp  Arg Val Arg Glu Gln  Ile Phe Asp 
    1010                 1015                 1020             


Gly Val  Phe Lys Leu Glu Glu  Ala Ile Ser Gln Lys  Asp Leu Ala 
    1025                 1030                 1035             


Gly Ile  Trp Ala Leu Glu Gln  Glu Ala Arg Gly Arg  Lys Asn Tyr 
    1040                 1045                 1050             


His Gln  Val Gln Phe Asn Ile  Phe Glu Lys Tyr Leu  Gln Asn Thr 
    1055                 1060                 1065             


Leu Pro  Ser Tyr Asp Pro Ala  Ile Gly Val Ile Arg  Asn Lys Phe 
    1070                 1075                 1080             


Ser His  Asn Glu Phe Pro Asp  Leu Ile Gly Gln Gly  Ile Glu Lys 
    1085                 1090                 1095             


Ile Ser  Gln Ala Gln Ile Asp  Asp Tyr Gln Arg Asn  Lys His Leu 
    1100                 1105                 1110             


Lys Asp  Tyr Leu Ala His Ala  Gly Ile Ser Ile Ala  Gln Gln Ile 
    1115                 1120                 1125             


Leu Ala  Ile Phe Glu Gln Lys  Ile Asn Asp Thr Leu  Thr Gln Leu 
    1130                 1135                 1140             


Thr Thr  His Gly 
    1145         


<210>  2452
<211>  1140
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2452

Met Glu Asn Thr Ser Leu Arg Thr Phe Lys Arg Phe Phe Asp Phe Lys 
1               5                   10                  15      


Gly Ser Val Ala Pro Ile Ala Glu Lys Ala Asn Arg Asn Tyr Ala Leu 
            20                  25                  30          


Lys Lys Arg Asn Asn Val Asn Leu Gln Gln Arg Leu His Tyr Phe Ala 
        35                  40                  45              


Val Gly His Ala Phe Lys Asn Ile Asp Val Glu Asn Ile Phe Arg Ala 
    50                  55                  60                  


Glu Leu Asp Glu Glu Thr Lys Gly Lys Lys Pro Thr Lys Phe Leu Ala 
65                  70                  75                  80  


Leu Gln Leu Ser Asn Phe Thr Phe Ile Lys Glu Leu Gly Cys Leu Leu 
                85                  90                  95      


Ser Asn Ile Arg Asn Ile Asn Ser His Phe Ile His Asp Phe Glu Leu 
            100                 105                 110         


Ile Lys Leu Asp Lys Ile Asp Asp Lys Ile Ile Glu Phe Leu Lys Gln 
        115                 120                 125             


Ser Phe Tyr Leu Ala Val Ile Gln Thr Cys Ile Lys Glu Lys Glu Thr 
    130                 135                 140                 


Thr Tyr Ile Asp Phe Ile Ser Thr Lys Asp Tyr Glu Lys Gln Ile Val 
145                 150                 155                 160 


Asn Phe Leu Leu Glu Lys Phe Tyr Pro Phe Asn Asp Lys Arg Lys Lys 
                165                 170                 175     


Leu Thr Glu Glu Glu Glu Lys Arg Val Lys Glu Tyr Lys Ser Phe Arg 
            180                 185                 190         


Asn Asp Phe Lys Asn Lys Ser Ile Asp Glu Ala Ile Asp Ser Ile Leu 
        195                 200                 205             


Phe Val Lys Val Asn Glu Thr Val Glu Trp Asn Leu Phe Glu Thr His 
    210                 215                 220                 


Asn Val Phe Asn Ile Thr Ser Gly Lys Tyr Leu Ser Phe Glu Ala Cys 
225                 230                 235                 240 


Leu Phe Leu Leu Thr Met Phe Leu Tyr Lys Gly Glu Ala Asn Gln Leu 
                245                 250                 255     


Ile Ser Lys Ile Lys Gly Phe Lys Arg Asn Asp Asp Asp Lys Tyr Arg 
            260                 265                 270         


Ser Lys Arg Asn Leu Phe Ser Phe Phe Ser Lys Lys Phe Ser Ser Gln 
        275                 280                 285             


Asp Ile Asp Ser Glu Glu Asn His Leu Val Lys Phe Arg Asp Leu Ile 
    290                 295                 300                 


Gln Tyr Leu Asn His Tyr Pro Thr Pro Trp Asn Lys Asp Leu Glu Leu 
305                 310                 315                 320 


Glu Ser Ala Asn Pro Ala Met Thr Asn Lys Leu Lys Glu Lys Ile Ile 
                325                 330                 335     


Glu Met Glu Ile Tyr Arg Ser Phe Pro Asp Phe Ala Asn Asp Glu Arg 
            340                 345                 350         


Phe Phe Val Phe Ala Lys Tyr Gln Ile Phe Gly Lys Lys Tyr Leu Gly 
        355                 360                 365             


Glu Asn Ile Glu Lys Glu Tyr Met Asp Asn Ser Phe Thr Ala Ala Glu 
    370                 375                 380                 


Lys Ile Ala Tyr Glu Tyr Glu Ile Lys Ile Ser Pro Glu Ile Lys Asp 
385                 390                 395                 400 


Ala Asn Asn Lys Leu Lys Glu Leu Lys Ala Lys Gln Gly Pro Tyr Gly 
                405                 410                 415     


Lys Gln Lys Glu Arg Asn Glu Lys Ile Ile Arg Glu Leu Glu Ser Met 
            420                 425                 430         


Ile Lys Asp Gly Lys Asn Asp Pro Asn Pro Ile Thr Glu Lys Leu Lys 
        435                 440                 445             


Thr Arg Ile Val Lys Asn Leu Leu Tyr Val Ser Tyr Gly Arg Asn Gln 
    450                 455                 460                 


Asp Arg Phe Met Asp Phe Ala Thr Arg Phe Leu Ala Glu Glu Lys Tyr 
465                 470                 475                 480 


Phe Gly Glu Asp Ala Glu Phe Lys Met Tyr Lys Phe Phe Ser Ser Glu 
                485                 490                 495     


Glu Gln Glu Asn Asn Ile Ser Thr Leu Lys Lys Glu Leu Ser Lys Lys 
            500                 505                 510         


Gln Tyr Asp Asn Leu Lys Phe His Gln Gly Lys Leu Val His Phe Cys 
        515                 520                 525             


Thr Phe Asp Glu His Leu Lys Asn Tyr Glu Ser Trp Asp Asp Pro Phe 
    530                 535                 540                 


Val Ile Glu Asn Asn Ala Val Gln Val Lys Val Tyr Leu Ser Asn Gly 
545                 550                 555                 560 


Ile Asn Lys Ile Val Ser Ile Gln Gln Asn Leu Met Ile Tyr Phe Leu 
                565                 570                 575     


Glu Asp Ala Leu Tyr Cys Asn Glu Asn Val Lys Glu Leu Gly Lys Thr 
            580                 585                 590         


Leu Leu Thr Asp Tyr Tyr Leu Met His Lys Glu Glu Phe Glu His Thr 
        595                 600                 605             


Lys Leu Phe Leu Gln Gln Asn Pro Thr Ile Ser Arg Glu Asp Lys Thr 
    610                 615                 620                 


Val Phe Lys Lys Ile Leu Pro Lys Arg Leu Leu His His Tyr Ser Pro 
625                 630                 635                 640 


Ala Met Gln Asn Asn Leu Pro Glu Phe Ser Thr Phe Gln Leu Leu Phe 
                645                 650                 655     


Glu Lys Ala Lys Arg Leu Glu Glu Arg Tyr Asn Lys Leu Lys Asn Lys 
            660                 665                 670         


Ala Glu Asp Glu Gly Asn Leu Asp Asp Phe Leu Lys Arg Asn Lys Gly 
        675                 680                 685             


Arg Gln Phe Lys Leu Gln Phe Ile Arg Lys Ala Cys His Leu Met Tyr 
    690                 695                 700                 


Phe Lys Glu Ser Tyr Leu Arg Gln Val Gln Glu Ala Gly His His Lys 
705                 710                 715                 720 


Arg Phe His Ile Ser Lys Asp Glu Phe Asn Asp Phe Ser Lys Trp Met 
                725                 730                 735     


Tyr Ala Phe Asp Glu Thr Pro Lys Tyr Lys Asp Tyr Leu Arg Glu Leu 
            740                 745                 750         


Phe Ser Gln Lys Gly Phe Phe Asp Asn Pro Ala Tyr Lys Lys Leu Phe 
        755                 760                 765             


Glu Asp Ser Val Ser Leu Asp Thr Met Tyr Leu Gln Thr Lys Lys Asn 
    770                 775                 780                 


Tyr Glu Glu Trp Leu Lys Thr Phe Val Pro Gly Gln Arg Ala Thr Asp 
785                 790                 795                 800 


Lys Tyr Ser Leu Asn Asn Tyr Val Lys Phe Phe Asp Asn Asp Leu Phe 
                805                 810                 815     


Phe Ile Asn Ile Ser His Phe Ile His Phe Leu Glu Ser Arg Asn Lys 
            820                 825                 830         


Leu Gln Arg Glu Glu Asn Gly Asn Ile Ile Tyr His Ser Leu Ser Asn 
        835                 840                 845             


Ser Glu Tyr Leu Ile Asn Glu Tyr Tyr Phe Lys Asp Lys Leu Glu Lys 
    850                 855                 860                 


Ser Glu Tyr Lys Thr Cys Gly Lys Leu Tyr Asn Lys Leu Lys Thr Ile 
865                 870                 875                 880 


Lys Leu Glu Asp Ser Leu Leu Tyr Glu Met Ser Met His Tyr Leu Gln 
                885                 890                 895     


Ile Asp Lys Ser Ile Val Lys Asn Ala Arg Thr Ser Ile Ile Asn Leu 
            900                 905                 910         


Leu Val Gln Asp Val Lys Phe Ser Ile Glu Asp Ala Asn Lys Asn His 
        915                 920                 925             


Leu Tyr Asp Leu Phe Ile Pro Phe Asn Lys Ile Asp Ser Phe Val Glu 
    930                 935                 940                 


Leu Ile Lys His Lys Glu Glu Gln Glu Gln Asp Lys Arg Phe Gly Gly 
945                 950                 955                 960 


Asn Ser Phe Leu Ser Lys Leu Ser Ser Tyr Ile Glu Lys Val Arg Asn 
                965                 970                 975     


Asn Lys Asp Ile Lys Pro Ile Phe Asp Arg Phe Ile Lys Lys Asn Ser 
            980                 985                 990         


Leu Asn Phe Asp Asp Leu Asn Lys  Ile Asn Asn His Ile  Ile Thr Asn 
        995                 1000                 1005             


Ser Ala  Lys Phe Thr Lys Val  Glu Leu Ser Leu Glu  Glu Tyr Phe 
    1010                 1015                 1020             


Ile Phe  Lys Asp Lys Ile Leu  Ile Lys Lys Glu Asn  Arg Ile Asn 
    1025                 1030                 1035             


Ile Asp  Glu Ile Lys Asn Leu  Ser Lys Tyr Phe Asn  Lys Val Asp 
    1040                 1045                 1050             


Arg His  Asn Ala Phe His Phe  Asn Val Pro Asn Glu  Cys Tyr Asp 
    1055                 1060                 1065             


Ile Phe  Leu Asn Lys Ile Glu  Ser Thr Tyr Val Lys  Asp Glu Val 
    1070                 1075                 1080             


Arg Pro  Val Ala Pro Lys Gln  Tyr Pro Asp Leu Thr  Lys Gln Gln 
    1085                 1090                 1095             


Arg Ser  Val Cys Ser Thr Phe  Leu Asp Ala Ile His  Asn Asp Phe 
    1100                 1105                 1110             


Phe Asn  Arg Ser Asp Arg Glu  Lys Met Arg Glu Glu  Ala Glu Asn 
    1115                 1120                 1125             


Lys Tyr  Phe Gln Lys Ile Ile  Leu Asn Arg Met Asn  
    1130                 1135                 1140 


<210>  2453
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2453

Met Asn Thr His Gln Glu Glu Leu Gln Ser Trp Ile Thr Arg Lys Arg 
1               5                   10                  15      


Leu Pro Asp Thr Glu Met Lys Lys Tyr Trp Ala Ala Tyr Met Asn Leu 
            20                  25                  30          


Ala Arg Leu Asn Phe Phe Lys Thr Leu Met Phe Ile Ser Asn Ser Ile 
        35                  40                  45              


Gly Asp Leu Lys Pro Ala Lys Asp Asn Asn Gly Lys Gly Asn Thr Glu 
    50                  55                  60                  


Val Asn Met His Asn Met Gly Ile Leu Thr Ala Leu Leu Gly Pro Glu 
65                  70                  75                  80  


Asp Glu Glu Lys Ala Arg Leu Leu Ile Phe Lys His Phe Pro Phe Leu 
                85                  90                  95      


Arg Thr Phe Cys Ile Glu Lys Glu Leu Ser Leu Ser Lys Gln Arg Thr 
            100                 105                 110         


Ile Leu Ile Asp Met Ala Cys Ile Ile Gly Arg Tyr Arg Asn Met Tyr 
        115                 120                 125             


Ser His Ser Ile Phe Leu Ser Asp Asp Asn Glu Lys Val Leu Glu Ser 
    130                 135                 140                 


Glu Lys Arg Cys Ser Glu Tyr Leu Gln Ser Ile Leu Thr Val Ser Thr 
145                 150                 155                 160 


Arg Ile Ile Lys Glu Arg Tyr Arg Ser Asn Lys Asn Asp Ala Gln Arg 
                165                 170                 175     


Gly Met Ile Asp Asp Lys Ser Leu Glu Phe Ile Ser Glu Asn Lys Val 
            180                 185                 190         


Lys Phe Val Tyr Asp Glu Asn Gly Lys Arg Ile Thr Ala Pro Asn Lys 
        195                 200                 205             


Lys Tyr Tyr Leu Ser Thr Ile Asp Lys Asp Asn Thr His Leu Ser Tyr 
    210                 215                 220                 


Phe Gly Lys Leu Met Leu Thr Cys Ile Leu Leu Glu Lys Lys Tyr Ala 
225                 230                 235                 240 


Thr Ala Phe Leu Thr Gln Cys His Phe Leu Asp Ala Phe Asn Asp Ser 
                245                 250                 255     


Glu Ala Ala Pro Lys Leu Ser Glu Arg Arg Leu Met Leu Glu Val Met 
            260                 265                 270         


Thr Ala Leu Arg Ile Arg Leu Ala Glu Lys Lys Leu Ser Asn Glu Lys 
        275                 280                 285             


Ser Glu Val Gln Ile Ser Leu Asp Ile Leu Asn Glu Leu Lys Lys Cys 
    290                 295                 300                 


Pro Phe Glu Leu Tyr Glu Leu Leu Gly Ser Glu Asp Lys Arg Leu Phe 
305                 310                 315                 320 


Thr Ile Val Ala Asp Thr Gly Glu Thr Ile Leu Leu Arg Arg His Glu 
                325                 330                 335     


Asp Arg Phe Pro Gln Leu Ala Leu Ser Trp Ile Asp Ser Ser Lys Ala 
            340                 345                 350         


Phe Asp His Leu Arg Phe Gln Val Asn Ala Gly Lys Leu Arg Tyr Leu 
        355                 360                 365             


Phe Arg Asp Asn Lys His Cys Ile Asp Gly Gln Thr Arg Met Arg Val 
    370                 375                 380                 


Leu Glu Glu Pro Leu Asn Gly Tyr Arg Arg Leu Met Glu Phe Glu Glu 
385                 390                 395                 400 


Glu Arg Ile Gln Lys Gln Ser Gly Glu Ile Arg Ser Leu Trp Pro Gly 
                405                 410                 415     


Leu Asp Ile Leu Asn Lys Asp Glu Thr Pro Arg Asn Asp Ala Ser Val 
            420                 425                 430         


Leu Pro Tyr Ile Ser Asp Tyr Arg Val Arg Tyr Leu Phe Asp Gly Asp 
        435                 440                 445             


Asn Ile Gly Ile Ser Ile Gly Asp Phe Thr Pro Ser Ile Thr Lys Thr 
    450                 455                 460                 


Asp Glu Thr Lys Tyr Arg Val Thr Gly Lys Thr Ala Asp Cys Cys Leu 
465                 470                 475                 480 


Ser Lys Tyr Glu Leu Pro Gly Leu Leu Phe Tyr His Leu Leu Thr Leu 
                485                 490                 495     


Arg Tyr Gly Asp Asn Lys Arg Ser Thr Lys Asn Ala Glu Asp Ile Ile 
            500                 505                 510         


Ile Asp Ala Ile Lys Arg Tyr Lys Arg Leu Phe Ser Asp Val Lys Glu 
        515                 520                 525             


Gly Ile Leu Lys Pro Ile Lys Glu Gly Asn Ala Asn Gln Leu Gly Asn 
    530                 535                 540                 


Arg Ile Trp Asn Ser Tyr Gly Ile Asp Ile Lys Asp Ile Pro Asp Lys 
545                 550                 555                 560 


Ile Ile Asp Tyr Leu Leu Val Arg Glu Cys Asn Glu Asp Glu Lys Phe 
                565                 570                 575     


Thr Ala Trp Lys Asn Gly Leu Ile Ser Glu Met Leu Gln Ser Thr Lys 
            580                 585                 590         


Asn Arg Ile Lys Arg Phe Glu Lys Asp Ser Glu Ala Val Ile Ser Ser 
        595                 600                 605             


Asp Asn Lys Pro Gly Lys Lys Asn His Val Ser Leu Lys Pro Gly Ala 
    610                 615                 620                 


Tyr Ala Ser Phe Ile Ala Asn Asp Ile Val Phe Phe Gln Glu Cys Gly 
625                 630                 635                 640 


Ala Thr Glu Lys Met Thr Gly Leu Asn Phe Lys Val Met Gln Ser Arg 
                645                 650                 655     


Leu Ala Thr Phe Thr Lys Asp Gly Ser Thr Ser Phe Asn Ile Leu Leu 
            660                 665                 670         


Gln Thr Leu Lys Asn Ala His Leu Val Ser Asn Thr Tyr Gly Lys Gly 
        675                 680                 685             


Asp His Pro Phe Leu Tyr Arg Val Ile Lys Gln Gln Pro Ser Asp Ile 
    690                 695                 700                 


Val Gln Phe Tyr Lys Ile Tyr Leu Asn Glu Lys Val Leu Tyr Leu Gln 
705                 710                 715                 720 


Ser Asp Ile Pro Asp Asn Ala Ile Phe Leu His Gly Glu Arg Lys Arg 
                725                 730                 735     


Trp Glu Asn Arg Asn Glu Gln Tyr Tyr Arg Asp Leu Ala Glu Arg Tyr 
            740                 745                 750         


Leu Gln Arg Pro Ile Gln Leu Pro Arg Gln Leu Phe Glu Ser His Ile 
        755                 760                 765             


Arg Gln Leu Leu Leu Ser Asp Cys Ile Lys Gly Glu Arg Gly Asn Asp 
    770                 775                 780                 


Leu Lys Glu Ala Ile Asn Ser Ala Ala Ser Gln Gly Arg Cys Asn Thr 
785                 790                 795                 800 


Thr Tyr Met Ile Met Glu Tyr Phe Ala Asp Tyr Leu Cys Asp Gly Thr 
                805                 810                 815     


Gln Phe Phe Tyr Gly Leu Phe Asp Gly Asp Leu Ser His Glu Tyr Asn 
            820                 825                 830         


Tyr Arg Phe Tyr Ser Leu Ile Ser Asn Asn Ile Glu Asn Ser Lys Lys 
        835                 840                 845             


Leu Val Leu Thr Leu Lys Lys Gly Asn Asn Ser Lys Glu Ser Pro Phe 
    850                 855                 860                 


Ile Ser Ala Leu Glu Arg Gly Ile His Trp Ser Lys Arg Asn Pro Leu 
865                 870                 875                 880 


Met Lys Lys Gly Leu Lys Asn Asp Ser Ser Glu Gly Asp Phe Val His 
                885                 890                 895     


Ala Ala Lys Arg Ala Tyr Lys Glu Met Thr Glu Thr Glu Arg Met Phe 
            900                 905                 910         


Arg Arg Tyr Ala Val Gln Asp Glu Val Leu Phe Leu Ala Ala Lys Ile 
        915                 920                 925             


Thr Ile Arg Arg Ala Leu Gly Leu Ser Glu Gln Tyr Asn Cys Leu Leu 
    930                 935                 940                 


Gly Asp Ile Lys Pro Gln Gly Gly Ser Leu Leu Glu Gln Thr Ile Pro 
945                 950                 955                 960 


Ser Ile Thr Thr Lys His Thr Ile Asn Thr Gly Asn Lys Lys Gln Lys 
                965                 970                 975     


Pro Lys Gln Val Gln Ile Leu Gln Lys Asn Val Lys Leu Lys Asp Phe 
            980                 985                 990         


Gly Lys Val Phe Lys Leu Leu Asn  Asp Arg Arg Ile Phe  Asp Leu Leu 
        995                 1000                 1005             


Phe Asn  Lys Gly Asn Glu Ala  Val Ser Met Thr Asp  Leu Cys Glu 
    1010                 1015                 1020             


Glu Leu  Glu Arg Tyr Asp Arg  His Arg Val Asp Val  Phe Asp Ser 
    1025                 1030                 1035             


Val Leu  Lys Tyr Glu Ser Lys  Ile Thr Lys Gly Tyr  Thr Asn Lys 
    1040                 1045                 1050             


Glu Leu  Met Asn Glu Ser Gly  Gln Ile Asp Phe Lys  Ala Ile Gln 
    1055                 1060                 1065             


Ala Phe  Asp Lys Gln Asn Thr  Thr Ala Asp Lys Glu  Asp Leu Arg 
    1070                 1075                 1080             


Leu Ile  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Gln Tyr Asn 
    1085                 1090                 1095             


Asn Glu  Pro Ile Leu Phe Asp  Lys Asp Ile Pro Glu  Ile Ala Asp 
    1100                 1105                 1110             


Glu Ile  Ser Ile Ile Ala Lys  Asp Ile Glu Glu Asn  Thr Lys 
    1115                 1120                 1125         


<210>  2454
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2454

Met Asn Thr His Gln Glu Glu Leu Gln Ser Trp Ile Thr Arg Lys Arg 
1               5                   10                  15      


Leu Pro Asp Thr Glu Met Lys Lys Tyr Trp Ala Ala Tyr Met Asn Leu 
            20                  25                  30          


Ala Arg Leu Asn Phe Phe Lys Thr Leu Met Phe Ile Ser Asn Ser Ile 
        35                  40                  45              


Gly Asp Leu Lys Pro Ala Lys Asp Asn Asn Gly Lys Gly Asn Thr Glu 
    50                  55                  60                  


Val Asn Met His Asn Met Gly Ile Leu Thr Ala Leu Leu Gly Pro Glu 
65                  70                  75                  80  


Asp Glu Glu Lys Ala Arg Leu Leu Ile Phe Lys His Phe Pro Phe Leu 
                85                  90                  95      


Arg Thr Phe Cys Ile Glu Lys Glu Leu Ser Leu Ser Lys Gln Arg Thr 
            100                 105                 110         


Ile Leu Ile Asp Met Ala Cys Ile Ile Gly Arg Tyr Arg Asn Met Tyr 
        115                 120                 125             


Ser His Ser Ile Phe Leu Ser Asp Asp Asn Glu Lys Val Leu Glu Ser 
    130                 135                 140                 


Glu Lys Arg Cys Ser Glu Tyr Leu Gln Ser Ile Leu Thr Val Ser Thr 
145                 150                 155                 160 


Arg Ile Ile Lys Glu Arg Tyr Arg Ser Asn Lys Asn Asp Ala Gln Arg 
                165                 170                 175     


Gly Met Ile Asp Asp Lys Ser Leu Glu Phe Ile Ser Glu Asn Lys Val 
            180                 185                 190         


Lys Phe Val Tyr Asp Glu Asn Gly Lys Arg Ile Thr Ala Pro Asn Lys 
        195                 200                 205             


Lys Tyr Tyr Leu Ser Thr Ile Asp Lys Asp Asn Thr His Leu Ser Tyr 
    210                 215                 220                 


Phe Gly Lys Leu Met Leu Thr Cys Ile Leu Leu Glu Lys Lys Tyr Ala 
225                 230                 235                 240 


Thr Ala Phe Leu Thr Gln Cys His Phe Leu Asp Ala Phe Asn Asp Ser 
                245                 250                 255     


Glu Ala Ala Pro Lys Leu Ser Glu Arg Arg Leu Met Leu Glu Val Met 
            260                 265                 270         


Thr Ala Leu Arg Ile Arg Leu Ala Glu Lys Lys Leu Ser Asn Glu Lys 
        275                 280                 285             


Ser Glu Val Gln Ile Ser Leu Asp Ile Leu Asn Glu Leu Lys Lys Cys 
    290                 295                 300                 


Pro Phe Glu Leu Tyr Glu Leu Leu Gly Ser Glu Asp Lys Arg Leu Phe 
305                 310                 315                 320 


Thr Ile Val Ala Asp Thr Gly Glu Thr Ile Leu Leu Arg Arg His Glu 
                325                 330                 335     


Asp Arg Phe Pro Gln Leu Ala Leu Ser Trp Ile Asp Ser Ser Lys Ala 
            340                 345                 350         


Phe Asp His Leu Arg Phe Gln Val Asn Ala Gly Lys Leu Arg Tyr Leu 
        355                 360                 365             


Phe Arg Asp Asn Lys His Cys Ile Asp Gly Gln Thr Arg Met Arg Val 
    370                 375                 380                 


Leu Glu Glu Pro Leu Asn Gly Tyr Arg Arg Leu Met Glu Phe Glu Glu 
385                 390                 395                 400 


Glu Arg Ile Gln Lys Gln Ser Gly Glu Ile Arg Ser Leu Trp Pro Gly 
                405                 410                 415     


Leu Asp Ile Leu Asn Lys Asp Glu Thr Pro Arg Asn Asp Ala Ser Val 
            420                 425                 430         


Leu Pro Tyr Ile Ser Asp Tyr Arg Val Arg Tyr Leu Phe Asp Gly Asp 
        435                 440                 445             


Asn Ile Gly Ile Ser Ile Gly Asp Phe Thr Pro Ser Ile Thr Lys Thr 
    450                 455                 460                 


Asp Glu Thr Lys Tyr Arg Val Thr Gly Lys Thr Ala Asp Cys Cys Leu 
465                 470                 475                 480 


Ser Lys Tyr Glu Leu Pro Gly Leu Leu Phe Tyr His Leu Leu Thr Leu 
                485                 490                 495     


Arg Tyr Gly Asp Asn Lys Arg Ser Thr Lys Asn Ala Glu Asp Ile Ile 
            500                 505                 510         


Ile Asp Ala Ile Lys Arg Tyr Lys Arg Leu Phe Ser Asp Val Lys Glu 
        515                 520                 525             


Gly Ile Leu Lys Pro Ile Lys Glu Gly Asn Ala Asn Gln Leu Gly Asn 
    530                 535                 540                 


Arg Ile Trp Asn Ser Tyr Gly Ile Asp Ile Lys Asp Ile Pro Asp Lys 
545                 550                 555                 560 


Ile Ile Asp Tyr Leu Leu Val Arg Glu Cys Asn Glu Asp Glu Lys Phe 
                565                 570                 575     


Thr Ala Trp Lys Asn Gly Leu Ile Ser Glu Met Leu Gln Ser Thr Lys 
            580                 585                 590         


Asn Arg Ile Lys Arg Phe Glu Lys Asp Ser Glu Ala Val Ile Ser Ser 
        595                 600                 605             


Asp Asn Lys Pro Gly Lys Lys Asn His Val Ser Leu Lys Pro Gly Ala 
    610                 615                 620                 


Tyr Ala Ser Phe Ile Ala Asn Asp Ile Val Phe Phe Gln Glu Cys Gly 
625                 630                 635                 640 


Ala Thr Glu Lys Met Thr Gly Leu Asn Phe Lys Val Met Gln Ser Arg 
                645                 650                 655     


Leu Ala Thr Phe Thr Lys Asp Gly Ser Thr Ser Phe Asn Ile Leu Leu 
            660                 665                 670         


Gln Thr Leu Lys Asn Ala His Leu Val Ser Asn Thr Tyr Gly Lys Gly 
        675                 680                 685             


Asp His Pro Phe Leu Tyr Arg Val Ile Lys Gln Gln Pro Ser Asp Ile 
    690                 695                 700                 


Val Gln Phe Tyr Lys Ile Tyr Leu Asn Glu Lys Val Leu Tyr Leu Gln 
705                 710                 715                 720 


Ser Asp Ile Pro Asp Asn Ala Ile Phe Leu His Gly Glu Arg Lys Arg 
                725                 730                 735     


Trp Glu Asn Arg Asn Glu Gln Tyr Tyr Arg Asp Leu Ala Glu Arg Tyr 
            740                 745                 750         


Leu Gln Arg Pro Ile Gln Leu Pro Arg Gln Leu Phe Glu Ser His Ile 
        755                 760                 765             


Arg Gln Leu Leu Leu Ser Asp Cys Ile Lys Gly Glu Arg Gly Asn Asp 
    770                 775                 780                 


Leu Lys Glu Ala Ile Asn Ser Ala Ala Ser Gln Gly Arg Cys Asn Thr 
785                 790                 795                 800 


Thr Tyr Met Ile Met Glu Tyr Phe Ala Asp Tyr Leu Cys Asp Gly Thr 
                805                 810                 815     


Gln Phe Phe Tyr Gly Leu Phe Asp Gly Asp Leu Ser His Glu Tyr Asn 
            820                 825                 830         


Tyr Arg Phe Tyr Ser Leu Ile Ser Asn Asn Ile Glu Asn Ser Lys Lys 
        835                 840                 845             


Leu Val Leu Thr Leu Lys Lys Gly Asn Asn Ser Lys Glu Ser Pro Phe 
    850                 855                 860                 


Ile Ser Ala Leu Glu Arg Gly Ile His Trp Ser Lys Arg Asn Pro Leu 
865                 870                 875                 880 


Met Lys Lys Gly Leu Lys Asn Asp Ser Ser Glu Gly Asp Phe Val His 
                885                 890                 895     


Ala Ala Lys Arg Ala Tyr Lys Glu Met Thr Glu Thr Glu Arg Met Phe 
            900                 905                 910         


Arg Arg Tyr Ala Val Gln Asp Glu Val Leu Phe Leu Ala Ala Lys Ile 
        915                 920                 925             


Thr Ile Arg Arg Ala Leu Gly Leu Ser Glu Gln Tyr Asn Cys Leu Leu 
    930                 935                 940                 


Gly Asp Ile Lys Pro Gln Gly Gly Ser Leu Leu Glu Gln Thr Ile Pro 
945                 950                 955                 960 


Ser Ile Thr Thr Lys His Thr Ile Asn Thr Gly Asn Lys Lys Gln Lys 
                965                 970                 975     


Pro Lys Gln Val Gln Ile Leu Gln Lys Asn Val Lys Leu Lys Asp Phe 
            980                 985                 990         


Gly Lys Val Phe Lys Leu Leu Asn  Asp Arg Arg Ile Phe  Asp Leu Leu 
        995                 1000                 1005             


Phe Asn  Lys Gly Asn Glu Ala  Val Ser Met Thr Asp  Leu Cys Glu 
    1010                 1015                 1020             


Glu Leu  Glu Arg Tyr Asp Arg  His Arg Val Asp Val  Phe Asp Ser 
    1025                 1030                 1035             


Val Leu  Lys Tyr Glu Ser Lys  Ile Thr Lys Gly Tyr  Thr Asn Lys 
    1040                 1045                 1050             


Glu Leu  Met Asn Glu Ser Gly  Gln Ile Asp Phe Lys  Ala Ile Gln 
    1055                 1060                 1065             


Ala Phe  Asp Lys Gln Asn Thr  Thr Ala Asp Lys Glu  Asp Leu Arg 
    1070                 1075                 1080             


Leu Ile  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Gln Tyr Asn 
    1085                 1090                 1095             


Asn Glu  Pro Ile Leu Phe Asp  Lys Asp Ile Pro Glu  Ile Ala Asp 
    1100                 1105                 1110             


Glu Ile  Ser Ile Ile Ala Lys  Asp Ile Glu Glu Asn  Thr Lys 
    1115                 1120                 1125         


<210>  2455
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2455

Met Asn Thr His Gln Glu Glu Leu Gln Ser Trp Ile Thr Arg Lys Arg 
1               5                   10                  15      


Leu Pro Asp Thr Glu Met Lys Lys Tyr Trp Ala Ala Tyr Met Asn Leu 
            20                  25                  30          


Ala Arg Leu Asn Phe Phe Lys Thr Leu Met Phe Ile Ser Asn Ser Ile 
        35                  40                  45              


Gly Asp Leu Lys Pro Ala Lys Asp Asn Asn Gly Lys Gly Asn Thr Glu 
    50                  55                  60                  


Val Asn Met His Asn Met Gly Ile Leu Thr Ala Leu Leu Gly Pro Glu 
65                  70                  75                  80  


Asp Glu Glu Lys Ala Arg Leu Leu Ile Phe Lys His Phe Pro Phe Leu 
                85                  90                  95      


Arg Thr Phe Cys Ile Glu Lys Glu Leu Ser Leu Ser Lys Gln Arg Thr 
            100                 105                 110         


Ile Leu Ile Asp Met Ala Cys Ile Ile Gly Arg Tyr Arg Asn Met Tyr 
        115                 120                 125             


Ser His Ser Ile Phe Leu Ser Asp Asp Asn Glu Lys Val Leu Glu Ser 
    130                 135                 140                 


Glu Lys Arg Cys Ser Glu Tyr Leu Gln Ser Ile Leu Thr Val Ser Thr 
145                 150                 155                 160 


Arg Ile Ile Lys Glu Arg Tyr Arg Ser Asn Lys Asn Asp Ala Gln Arg 
                165                 170                 175     


Gly Met Ile Asp Asp Lys Ser Leu Glu Phe Ile Ser Glu Asn Lys Val 
            180                 185                 190         


Lys Phe Val Tyr Asp Glu Asn Gly Lys Arg Ile Thr Ala Pro Asn Lys 
        195                 200                 205             


Lys Tyr Tyr Leu Ser Thr Ile Asp Lys Asp Asn Thr His Leu Ser Tyr 
    210                 215                 220                 


Phe Gly Lys Leu Met Leu Thr Cys Ile Leu Leu Glu Lys Lys Tyr Ala 
225                 230                 235                 240 


Thr Ala Phe Leu Thr Gln Cys His Phe Leu Asp Ala Phe Asn Asp Ser 
                245                 250                 255     


Glu Ala Ala Pro Lys Leu Ser Glu Arg Arg Leu Met Leu Glu Val Met 
            260                 265                 270         


Thr Ala Leu Arg Ile Arg Leu Ala Glu Lys Lys Leu Ser Asn Glu Lys 
        275                 280                 285             


Ser Glu Val Gln Ile Ser Leu Asp Ile Leu Asn Glu Leu Lys Lys Cys 
    290                 295                 300                 


Pro Phe Glu Leu Tyr Glu Leu Leu Gly Ser Glu Asp Lys Arg Leu Phe 
305                 310                 315                 320 


Thr Ile Val Ala Asp Thr Gly Glu Thr Ile Leu Leu Arg Arg His Glu 
                325                 330                 335     


Asp Arg Phe Pro Gln Leu Ala Leu Ser Trp Ile Asp Ser Ser Lys Ala 
            340                 345                 350         


Phe Asp His Leu Arg Phe Gln Val Asn Ala Gly Lys Leu Arg Tyr Leu 
        355                 360                 365             


Phe Arg Asp Asn Lys His Cys Ile Asp Gly Gln Thr Arg Met Arg Val 
    370                 375                 380                 


Leu Glu Glu Pro Leu Asn Gly Tyr Arg Arg Leu Met Glu Phe Glu Glu 
385                 390                 395                 400 


Glu Arg Ile Gln Lys Gln Ser Gly Glu Ile Arg Ser Leu Trp Pro Gly 
                405                 410                 415     


Leu Asp Ile Leu Asn Lys Asp Glu Thr Pro Arg Asn Asp Ala Ser Val 
            420                 425                 430         


Leu Pro Tyr Ile Ser Asp Tyr Arg Val Arg Tyr Leu Phe Asp Gly Asp 
        435                 440                 445             


Asn Ile Gly Ile Ser Ile Gly Asp Phe Thr Pro Ser Ile Thr Lys Thr 
    450                 455                 460                 


Asp Glu Thr Lys Tyr Arg Val Thr Gly Lys Thr Ala Asp Cys Cys Leu 
465                 470                 475                 480 


Ser Lys Tyr Glu Leu Pro Gly Leu Leu Phe Tyr His Leu Leu Thr Leu 
                485                 490                 495     


Arg Tyr Gly Asp Asn Lys Arg Ser Thr Lys Asn Ala Glu Asp Ile Ile 
            500                 505                 510         


Ile Asp Ala Ile Lys Arg Tyr Lys Arg Leu Phe Ser Asp Val Lys Glu 
        515                 520                 525             


Gly Ile Leu Lys Pro Ile Lys Glu Gly Asn Ala Asn Gln Leu Gly Asn 
    530                 535                 540                 


Arg Ile Trp Asn Ser Tyr Gly Ile Asp Ile Lys Asp Ile Pro Asp Lys 
545                 550                 555                 560 


Ile Ile Asp Tyr Leu Leu Val Arg Glu Cys Asn Glu Asp Glu Lys Phe 
                565                 570                 575     


Thr Ala Trp Lys Asn Gly Leu Ile Ser Glu Met Leu Gln Ser Thr Lys 
            580                 585                 590         


Asn Arg Ile Lys Arg Phe Glu Lys Asp Ser Glu Ala Val Ile Ser Ser 
        595                 600                 605             


Asp Asn Lys Pro Gly Lys Lys Asn His Val Ser Leu Lys Pro Gly Ala 
    610                 615                 620                 


Tyr Ala Ser Phe Ile Ala Asn Asp Ile Val Phe Phe Gln Glu Cys Gly 
625                 630                 635                 640 


Ala Thr Glu Lys Met Thr Gly Leu Asn Phe Lys Val Met Gln Ser Arg 
                645                 650                 655     


Leu Ala Thr Phe Thr Lys Asp Gly Ser Thr Ser Phe Asn Ile Leu Leu 
            660                 665                 670         


Gln Thr Leu Lys Asn Ala His Leu Val Ser Asn Thr Tyr Gly Lys Gly 
        675                 680                 685             


Asp His Pro Phe Leu Tyr Arg Val Ile Lys Gln Gln Pro Ser Asp Ile 
    690                 695                 700                 


Val Gln Phe Tyr Lys Ile Tyr Leu Asn Glu Lys Val Leu Tyr Leu Gln 
705                 710                 715                 720 


Ser Asp Ile Pro Asp Asn Ala Ile Phe Leu His Gly Glu Arg Lys Arg 
                725                 730                 735     


Trp Glu Asn Arg Asn Glu Gln Tyr Tyr Arg Asp Leu Ala Glu Arg Tyr 
            740                 745                 750         


Leu Gln Arg Pro Ile Gln Leu Pro Arg Gln Leu Phe Glu Ser His Ile 
        755                 760                 765             


Arg Gln Leu Leu Leu Ser Asp Cys Ile Lys Gly Glu Arg Gly Asn Asp 
    770                 775                 780                 


Leu Lys Glu Ala Ile Asn Ser Ala Ala Ser Gln Gly Arg Cys Asn Thr 
785                 790                 795                 800 


Thr Tyr Met Ile Met Glu Tyr Phe Ala Asp Tyr Leu Cys Asp Gly Thr 
                805                 810                 815     


Gln Phe Phe Tyr Gly Leu Phe Asp Gly Asp Leu Ser His Glu Tyr Asn 
            820                 825                 830         


Tyr Arg Phe Tyr Ser Leu Ile Ser Asn Asn Ile Glu Asn Ser Lys Lys 
        835                 840                 845             


Leu Val Leu Thr Leu Lys Lys Gly Asn Asn Ser Lys Glu Ser Pro Phe 
    850                 855                 860                 


Ile Ser Ala Leu Glu Arg Gly Ile His Trp Ser Lys Arg Asn Pro Leu 
865                 870                 875                 880 


Met Lys Lys Gly Leu Lys Asn Asp Ser Ser Glu Gly Asp Phe Val His 
                885                 890                 895     


Ala Ala Lys Arg Ala Tyr Lys Glu Met Thr Glu Thr Glu Arg Met Phe 
            900                 905                 910         


Arg Arg Tyr Ala Val Gln Asp Glu Val Leu Phe Leu Ala Ala Lys Ile 
        915                 920                 925             


Thr Ile Arg Arg Ala Leu Gly Leu Ser Glu Gln Tyr Asn Cys Leu Leu 
    930                 935                 940                 


Gly Asp Ile Lys Pro Gln Gly Gly Ser Leu Leu Glu Gln Thr Ile Pro 
945                 950                 955                 960 


Ser Ile Thr Thr Lys His Thr Ile Asn Thr Gly Asn Lys Lys Gln Lys 
                965                 970                 975     


Pro Lys Gln Val Gln Ile Leu Gln Lys Asn Val Lys Leu Lys Asp Phe 
            980                 985                 990         


Gly Lys Val Phe Lys Leu Leu Asn  Asp Arg Arg Ile Phe  Asp Leu Leu 
        995                 1000                 1005             


Phe Asn  Lys Gly Asn Glu Ala  Val Ser Met Thr Asp  Leu Cys Glu 
    1010                 1015                 1020             


Glu Leu  Glu Arg Tyr Asp Arg  His Arg Val Asp Val  Phe Asp Ser 
    1025                 1030                 1035             


Val Leu  Lys Tyr Glu Ser Lys  Ile Thr Lys Gly Tyr  Thr Asn Lys 
    1040                 1045                 1050             


Glu Leu  Met Asn Glu Ser Gly  Gln Ile Asp Phe Lys  Ala Ile Gln 
    1055                 1060                 1065             


Ala Phe  Asp Lys Gln Asn Thr  Thr Ala Asp Lys Glu  Asp Leu Arg 
    1070                 1075                 1080             


Leu Ile  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Gln Tyr Asn 
    1085                 1090                 1095             


Asn Glu  Pro Ile Leu Phe Asp  Lys Asp Ile Pro Glu  Ile Ala Asp 
    1100                 1105                 1110             


Glu Ile  Ser Ile Ile Ala Lys  Asp Ile Glu Glu Asn  Thr Lys 
    1115                 1120                 1125         


<210>  2456
<211>  1118
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2456

Met Lys Glu Lys Glu Thr Pro Val Ala Ser Thr Val Asn Lys Asp Glu 
1               5                   10                  15      


Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val Tyr 
            20                  25                  30          


Ile Thr Ile Asn His Ile Asn Lys Leu Leu Glu Ile Arg Glu Ile Asp 
        35                  40                  45              


Asn Asp Glu Lys Val Leu Asp Ile Lys Thr Leu Trp Gln Lys Val Asn 
    50                  55                  60                  


Lys Asp Leu Asn Gln Lys Ala Arg Leu Arg Glu Leu Met Thr Lys His 
65                  70                  75                  80  


Phe Pro Phe Leu Glu Thr Ala Ile Tyr Ser Lys Asn Lys Glu Asp Lys 
                85                  90                  95      


Glu Glu Val Lys Gln Glu Lys Gln Ala Thr Ala Gln Ser Phe Lys Ser 
            100                 105                 110         


Leu Glu His Cys Leu Phe Leu Phe Leu Glu Lys Leu Gln Glu Ala Arg 
        115                 120                 125             


Asn Tyr Tyr Ser His Tyr Lys Tyr Ser Glu Ser Thr Lys Glu Pro Val 
    130                 135                 140                 


Leu Glu Lys Glu Leu Leu Lys Lys Met Tyr Asn Ile Phe Asp Asn Asn 
145                 150                 155                 160 


Ile Gln Leu Val Ile Lys Asp Tyr Gln His Asn Lys Asp Ile Asn Pro 
                165                 170                 175     


Asp Glu Asp Phe Lys His Leu Asp Arg Thr Glu Lys Glu Phe Asn Tyr 
            180                 185                 190         


Tyr Phe Thr Gln Asp Lys Lys Gly Lys Ile Thr Glu Ser Gly Leu Leu 
        195                 200                 205             


Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Met Gln 
    210                 215                 220                 


Gln Lys Phe Thr Gly Phe Lys Asp Asn Arg Glu Asn Asn Lys Gln Met 
225                 230                 235                 240 


Thr His Glu Val Phe Cys Arg Ser Arg Met Leu Leu Pro Lys Leu Arg 
                245                 250                 255     


Leu Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu Asn 
            260                 265                 270         


Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Lys Gly Glu 
        275                 280                 285             


Asp Arg Lys Lys Phe Glu Val Pro Phe Asp Ser Thr Asp Glu Asp Tyr 
    290                 295                 300                 


Asp Ala Glu Gln Asp Pro Phe Lys Asn Thr Leu Ile Arg His Gln Asp 
305                 310                 315                 320 


Arg Phe Pro Tyr Phe Ile Leu Arg Tyr Phe Asp Tyr Asn Glu Ile Phe 
                325                 330                 335     


Lys Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile 
            340                 345                 350         


Tyr Lys Lys Leu Ile Gly Gly Gln Lys Glu Tyr Arg His Leu Thr His 
        355                 360                 365             


Lys Leu Tyr Gly Phe Glu Arg Ile Gln Glu Phe Thr Lys Gln His Arg 
    370                 375                 380                 


Pro Asp Asp Trp Lys Ala Ile Val Lys Asp Phe Asp Thr Tyr Glu Thr 
385                 390                 395                 400 


Ser Glu Glu Pro Tyr Ile Ser Glu Thr Thr Pro His Tyr His Leu Glu 
                405                 410                 415     


Asn Gln Lys Ile Gly Ile Arg Phe Lys Asn Asp Asn Asp Lys Ile Trp 
            420                 425                 430         


Pro Ser Leu Glu Thr Asn Gly Glu Asn Asn Glu Lys Ser Lys Tyr Lys 
        435                 440                 445             


Leu Asp Lys Gln Tyr Gln Ala Glu Ala Phe Leu Ser Val His Glu Leu 
    450                 455                 460                 


Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Lys Lys Glu Glu Pro Asn 
465                 470                 475                 480 


Asn Asp Lys Lys Asn Ala Ser Arg Val Glu Gly Phe Ile Lys Arg Glu 
                485                 490                 495     


Ile Arg Asp Ile Phe Lys Leu Tyr Asp Ala Phe Ala Asn Asp Glu Ile 
            500                 505                 510         


Asn Asn Ile Asp Asp Leu Lys Lys Tyr Tyr Lys Asp Lys Asn Val Glu 
        515                 520                 525             


Ile Arg His Leu Pro Lys Gln Met Ile Ala Ile Leu Glu Ser Lys Pro 
    530                 535                 540                 


Lys Asp Met Ala Lys Glu Ala Lys Arg Lys Gln Lys Glu Met Val Lys 
545                 550                 555                 560 


Asp Thr Lys Lys Leu Leu Ala Thr Leu Glu Lys Gln Thr Gln Lys Glu 
                565                 570                 575     


Lys Glu Asp Glu Gly Arg Asn Val Lys Leu Leu Lys Ser Gly Glu Ile 
            580                 585                 590         


Ala Arg Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln Lys 
        595                 600                 605             


Asp Asn Glu Gly Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu 
    610                 615                 620                 


Tyr Gln Met Leu Gln Arg Ser Leu Ala Leu Tyr Asn Lys Glu Glu Lys 
625                 630                 635                 640 


Pro Thr Arg Tyr Phe Arg Gln Val Asn Leu Ile Glu Ser Ser Asn Pro 
                645                 650                 655     


His Pro Phe Leu Lys Trp Thr Lys Trp Glu Glu Cys Asn Asn Ile Leu 
            660                 665                 670         


Thr Phe Tyr His Arg Tyr Leu Thr Lys Lys Ile Glu Phe Leu Asn Lys 
        675                 680                 685             


Leu Lys Pro Glu Asp Trp Lys Lys Asn Gln Tyr Phe Leu Lys Val Lys 
    690                 695                 700                 


Glu Pro Lys Thr Asn Arg Glu Thr Leu Val Gln Gly Trp Lys Asn Gly 
705                 710                 715                 720 


Phe Asn Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg Glu Trp Phe 
                725                 730                 735     


Glu Arg His Gln Asn Asp Ser Glu Glu Tyr Lys Lys Val Glu Lys Leu 
            740                 745                 750         


Asn Lys Ala Gly Leu Val Thr Lys Val Ile Pro Leu Phe Phe Lys Glu 
        755                 760                 765             


Glu Pro Phe Lys Glu Asp Thr Lys Lys Glu Ile Asn Asp Trp Val Gln 
    770                 775                 780                 


Pro Phe Tyr Ser Phe Pro Tyr Asn Val Gly Asn Ile His Lys Pro Lys 
785                 790                 795                 800 


Glu Glu Asp Phe Leu His Arg Glu Glu Arg Ile Glu Leu Trp Asp Lys 
                805                 810                 815     


Lys Lys Asp Lys Phe Lys Gly Tyr Lys Glu Lys Ile Lys Ser Lys Lys 
            820                 825                 830         


Leu Thr Glu Lys Glu Lys Glu Glu Phe Arg Ser Tyr Leu Glu Phe Gln 
        835                 840                 845             


Ser Trp Asn Lys Phe Glu Arg Glu Leu Arg Leu Val Arg Asn Gln Asp 
    850                 855                 860                 


Ile Val Thr Trp Leu Leu Cys Lys Glu Leu Ile Asp Lys Leu Lys Ile 
865                 870                 875                 880 


Asp Glu Leu Asn Ile Glu Glu Leu Lys Lys Leu Arg Leu Asn Asn Ile 
                885                 890                 895     


Asp Thr Asp Thr Ala Lys Lys Glu Lys Asn Asn Ile Leu Asn Arg Val 
            900                 905                 910         


Met Pro Met Glu Leu Pro Val Thr Val Tyr Glu Val Ser Lys Ala Gly 
        915                 920                 925             


Asn Ile Ile Lys Asp Lys Pro Leu His Thr Ile Tyr Ile Lys Glu Ala 
    930                 935                 940                 


Lys Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys Asp 
945                 950                 955                 960 


Arg Arg Leu Asn Gly Leu Phe Ser Phe Val Lys Thr Asn Ser Glu Ala 
                965                 970                 975     


Glu Ser Lys Arg Asn Pro Ile Ser Lys Leu Arg Val Glu His Glu Leu 
            980                 985                 990         


Gly Glu Tyr Gln Glu Ala Arg Ile  Glu Ile Ile Lys Asp  Met Leu Ala 
        995                 1000                 1005             


Leu Glu  Glu Thr Leu Ile Asn  Lys Tyr Lys Asp Leu  Pro Thr Asn 
    1010                 1015                 1020             


Lys Phe  Ser Asp Met Leu Asn  Ser Trp Leu Glu Gly  Lys Asp Glu 
    1025                 1030                 1035             


Ala Asp  Lys Ala Arg Phe Gln  Asn Asp Val Asp Phe  Leu Ile Ala 
    1040                 1045                 1050             


Val Arg  Asn Ala Phe Ser His  Asn Gln Tyr Pro Met  His Asn Lys 
    1055                 1060                 1065             


Ile Glu  Phe Ala Asn Ile Lys  Pro Phe Ser Leu Tyr  Thr Met Asn 
    1070                 1075                 1080             


Asn Ser  Glu Glu Lys Gly Leu  Gly Ile Ala Asn Gln  Leu Lys Asp 
    1085                 1090                 1095             


Lys Thr  Lys Glu Thr Lys Asp  Lys Ile Ile Glu Ile  Glu Lys Pro 
    1100                 1105                 1110             


Ile Glu  Thr Lys Glu 
    1115             


<210>  2457
<211>  1146
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2457

Met Glu Ser Ile Ile Gly Leu Gly Leu Ser Phe Asn Pro Tyr Lys Thr 
1               5                   10                  15      


Ala Asp Lys His Tyr Phe Gly Ser Phe Leu Asn Leu Ala Asp Asn Asn 
            20                  25                  30          


Leu Lys Ala Val Phe Ala Glu Phe Lys Glu Arg Ile Ser Asp Lys Ser 
        35                  40                  45              


Lys Asp Glu Asp Ile Ser Asn Leu Ile Glu Lys His Phe Ile Asp Asn 
    50                  55                  60                  


Met Ser Ile Val Asp Tyr Glu Lys Asn Ile Ser Ile Leu Asn Gly Tyr 
65                  70                  75                  80  


Leu Pro Ile Ile Asp Phe Leu Asp Asp Glu Leu Glu Asn Asn Leu Asn 
                85                  90                  95      


Thr Arg Val Lys Asn Phe Lys Lys Ser Phe Ile Ile Leu Ala Glu Ala 
            100                 105                 110         


Leu Glu Thr Leu Arg Asn Tyr Tyr Thr His Phe Tyr His Asp Pro Ile 
        115                 120                 125             


Thr Phe Gly Asp Asn Lys Glu Pro Leu Leu Glu Leu Leu Asp Glu Val 
    130                 135                 140                 


Leu Leu Lys Thr Ile Leu Asp Val Lys Lys Lys Tyr Leu Lys Thr Asp 
145                 150                 155                 160 


Lys Thr Lys Glu Ile Leu Lys Asp Ser Leu Arg Glu Glu Met Asp Leu 
                165                 170                 175     


Leu Val Ile Arg Lys Thr Asp Glu Leu Arg Glu Lys Lys Lys Thr Asn 
            180                 185                 190         


Pro Lys Phe Lys Phe Ser Thr Asp Pro Thr Gln Ile Arg Asn Ser Ile 
        195                 200                 205             


Phe Asn Asp Ala Phe Gln Gly Leu Leu Tyr Glu Asp Lys Glu Asn Asn 
    210                 215                 220                 


Gly Lys Thr Gln Val Ser Tyr Arg Ala Lys Thr Lys Leu Asn Pro Lys 
225                 230                 235                 240 


Asp Ile His Lys Gln Glu Glu Arg Asp Phe Glu Ile Pro Leu Ser Thr 
                245                 250                 255     


Ser Gly Ile Val Phe Leu Met Ser Leu Phe Leu Ser Lys Lys Glu Ile 
            260                 265                 270         


Glu Asp Phe Lys Ser Asn Ile Lys Gly Phe Lys Gly Lys Val Val Lys 
        275                 280                 285             


Asp Glu Asn His Asn Ser Leu Lys Tyr Met Ala Thr His Arg Val Tyr 
    290                 295                 300                 


Ser Ile Leu Ala Phe Lys Gly Leu Lys Tyr Arg Ile Lys Thr Asp Thr 
305                 310                 315                 320 


Phe Ser Lys Val Thr Leu Met Met Gln Met Ile Asp Glu Leu Ser Lys 
                325                 330                 335     


Val Pro Asp Cys Val Tyr Gln Asn Leu Ser Glu Thr Lys Gln Lys Asp 
            340                 345                 350         


Phe Ile Glu Asp Trp Asn Glu Tyr Leu Lys Asp Asn Glu Glu Asn Thr 
        355                 360                 365             


Glu Asn Leu Glu Asn Ser Arg Val Val His Pro Leu Ile Arg Lys Arg 
    370                 375                 380                 


Tyr Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe 
385                 390                 395                 400 


Ala Asn Phe Lys Thr Leu Lys Phe Gln Val Phe Met Gly Tyr Tyr Ile 
                405                 410                 415     


His Asp Gln Arg Thr Lys Thr Ile Gly Thr Thr Asn Ile Thr Thr Glu 
            420                 425                 430         


Arg Thr Val Lys Glu Lys Ile Asn Val Phe Gly Lys Leu Ser Lys Met 
        435                 440                 445             


Asp Asn Leu Lys Lys His Phe Phe Ser Gln Leu Ser Asp Glu Glu Asn 
    450                 455                 460                 


Thr Asp Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Phe Leu Thr Gln 
465                 470                 475                 480 


Ala Asp Asn Ser Pro Ala Asn Asn Ile Pro Ile Tyr Leu Glu Leu Lys 
                485                 490                 495     


Asn Gln Gln Ile Ile Lys Glu Lys Asp Asp Ile Lys Ala Glu Val Asn 
            500                 505                 510         


Asn Ser Gln Asn Arg Asn Pro Asn Lys Pro Ser Lys Arg Asp Leu Leu 
        515                 520                 525             


Asn Lys Ile Ser Asn Thr Asn Glu Asp Phe Tyr Gln Gly Asp Pro Thr 
    530                 535                 540                 


Ala Ile Leu Ser Leu Asn Glu Ile Pro Ala Leu Leu His Leu Phe Leu 
545                 550                 555                 560 


Val Gln Pro Asp Asn Lys Thr Gly Gln Gln Ile Glu Asn Ile Ile Arg 
                565                 570                 575     


Ile Lys Ile Glu Lys Gln Phe Asn Ser Ile Lys Asn Pro Ser Lys Asp 
            580                 585                 590         


Asp Lys Gly Val Pro Lys Ser Leu Phe Ala Asp Thr Asn Val Arg Val 
        595                 600                 605             


Asn Ala Ile Lys Leu Lys Lys Asp Leu Gly Glu Glu Leu Asp Met Leu 
    610                 615                 620                 


Asn Lys Lys Gln Ile Val Phe Lys Glu Asn Gln Lys Ala Ser Ser Asn 
625                 630                 635                 640 


Tyr Asp Glu Leu Leu Lys Lys His Gln Phe Thr Pro Lys Asn Lys Arg 
                645                 650                 655     


Pro Ala Leu Arg Lys Tyr Val Phe Tyr Asn Ser Glu Lys Gly Glu Glu 
            660                 665                 670         


Ala Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Lys Gly Phe 
        675                 680                 685             


Lys Thr Lys Trp Lys Gly Tyr Gln His Ser Glu Leu Gln Arg Lys Leu 
    690                 695                 700                 


Ala Phe Tyr Asp Arg His Thr Lys Gln Asp Ile Lys Glu Leu Leu Ser 
705                 710                 715                 720 


Gly Cys Glu Phe Asp His Phe Leu Leu Asp Ile Asn Ala Cys Phe Lys 
                725                 730                 735     


Glu Asp Asp Phe Glu Asp Phe Phe Ser Lys Tyr Leu Lys Asn Arg Ile 
            740                 745                 750         


Glu Thr Leu Asn Ile Ile Leu Lys Gln Leu His Asp Phe Lys Asn Glu 
        755                 760                 765             


Pro Thr Pro Leu Lys Gly Val Phe Lys Asn Cys Leu Lys Phe Leu Lys 
    770                 775                 780                 


Gln Lys Asn Tyr Val Thr Glu Asn Pro Glu Ile Ile Lys Lys Arg Ile 
785                 790                 795                 800 


Leu Ala Lys Pro Ala Phe Leu Pro Arg Gly Ile Phe Asp Glu Arg Pro 
                805                 810                 815     


Thr Met Lys Lys Gly Lys Asn Pro Leu Ile Asp Arg Asp Glu Phe Ala 
            820                 825                 830         


Lys Trp Phe Val Glu Tyr Leu Glu Asn Lys Asp Tyr Gln Lys Phe Tyr 
        835                 840                 845             


Asn Ser Glu Glu Tyr Arg Ile Arg Asp Ala Asp Phe Lys Lys Asn Ala 
    850                 855                 860                 


Val Ile Lys Lys Gln Lys Leu Lys Asp Phe Tyr Thr Leu Gln Met Val 
865                 870                 875                 880 


Asn Tyr Leu Leu Lys Glu Val Phe Gly Lys Asp Glu Met Asn Leu Gln 
                885                 890                 895     


Leu Ser Glu Leu Phe Gln Thr Arg Gln Glu Arg Leu Lys Leu Gln Gly 
            900                 905                 910         


Ile Ala Lys Lys Gln Met Asn Lys Glu Thr Gly Asp Ser Ser Glu Asn 
        915                 920                 925             


Thr Arg Asn Gln Thr Tyr Ile Trp Asn Lys Asp Val Pro Val Ser Phe 
    930                 935                 940                 


Phe Asn Gly Lys Val Thr Ile Asp Lys Val Lys Leu Lys Asn Ile Gly 
945                 950                 955                 960 


Lys Tyr Lys Arg Tyr Glu Arg Asp Glu Arg Val Lys Thr Phe Ile Gly 
                965                 970                 975     


Tyr Glu Val Asp Glu Lys Trp Met Met Tyr Leu Pro His Asn Trp Lys 
            980                 985                 990         


Asp Arg Tyr Ser Val Lys Pro Ile  Asn Val Ile Asp Leu  Gln Ile Gln 
        995                 1000                 1005             


Glu Tyr  Glu Glu Ile Arg Ser  His Glu Leu Leu Lys  Glu Ile Gln 
    1010                 1015                 1020             


Asn Leu  Glu Gln Tyr Ile Tyr  Asp His Thr Thr Asp  Lys Asn Thr 
    1025                 1030                 1035             


Leu Leu  Gln Asp Gly Asn Pro  Asn Phe Lys Met Tyr  Val Leu Asn 
    1040                 1045                 1050             


Gly Leu  Leu Thr Gly Ile Lys  Gln Val Asn Ile Ala  Asp Phe Ile 
    1055                 1060                 1065             


Val Leu  Lys Gln Asn Thr Asn  Phe Asp Lys Ile Asp  Phe Thr Gly 
    1070                 1075                 1080             


Ile Ala  Ser Cys Ser Glu Leu  Glu Lys Lys Thr Ile  Ile Leu Ile 
    1085                 1090                 1095             


Ala Ile  Arg Asn Lys Phe Ala  His Asn Gln Leu Pro  Asn Lys Thr 
    1100                 1105                 1110             


Ile Tyr  Asp Leu Ala Asn Glu  Phe Leu Lys Lys Glu  Lys Arg Glu 
    1115                 1120                 1125             


Thr Tyr  Ala Asn Tyr Tyr Leu  Lys Val Leu Lys Lys  Met Ile Ser 
    1130                 1135                 1140             


Asp Leu  Ala 
    1145     


<210>  2458
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2458

Leu Gln Lys Gln Asp Lys Leu Phe Val Asp Arg Lys Lys Asn Ala Ile 
1               5                   10                  15      


Phe Ala Phe Pro Lys Tyr Ile Thr Ile Met Glu Asn Lys Glu Lys Pro 
            20                  25                  30          


Glu Pro Ile Tyr Tyr Glu Leu Thr Asp Lys His Phe Trp Ala Ala Phe 
        35                  40                  45              


Leu Asn Leu Ala Arg His Asn Val Tyr Thr Thr Ile Asn His Ile Asn 
    50                  55                  60                  


Arg Arg Leu Glu Ile Ala Glu Leu Lys Asp Asp Gly Tyr Met Met Gly 
65                  70                  75                  80  


Ile Lys Gly Ser Trp Asn Glu Gln Ala Lys Lys Leu Asp Lys Lys Val 
                85                  90                  95      


Arg Leu Arg Asp Leu Ile Met Lys His Phe Pro Phe Leu Glu Ala Ala 
            100                 105                 110         


Ala Tyr Glu Ile Thr Asn Ser Lys Ser Pro Asn Asn Lys Glu Gln Arg 
        115                 120                 125             


Glu Lys Glu Gln Ser Glu Ala Leu Ser Leu Asn Asn Leu Lys Asn Val 
    130                 135                 140                 


Leu Phe Ile Phe Leu Glu Lys Leu Gln Val Leu Arg Asn Tyr Tyr Ser 
145                 150                 155                 160 


His Tyr Lys Tyr Ser Glu Glu Ser Pro Lys Pro Thr Phe Glu Thr Ser 
                165                 170                 175     


Leu Leu Lys Asn Met Tyr Lys Val Phe Asp Ala Asn Val Arg Leu Val 
            180                 185                 190         


Lys Arg Asp Tyr Met His His Glu Asn Ile Asp Met Gln Arg Asp Phe 
        195                 200                 205             


Thr His Leu Asn Arg Lys Lys Gln Val Gly Arg Thr Lys Asn Ile Ile 
    210                 215                 220                 


Asp Ser Pro Asn Phe His Tyr His Phe Ala Asp Lys Glu Gly Asn Met 
225                 230                 235                 240 


Thr Ile Ala Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Asp Lys Lys 
                245                 250                 255     


Asp Ala Ile Trp Met Gln Lys Lys Leu Lys Gly Phe Lys Asp Gly Arg 
            260                 265                 270         


Asn Leu Arg Glu Gln Met Thr Asn Glu Val Phe Cys Arg Ser Arg Ile 
        275                 280                 285             


Ser Leu Pro Lys Leu Lys Leu Glu Asn Val Gln Thr Lys Asp Trp Met 
    290                 295                 300                 


Gln Leu Asp Met Leu Asn Glu Leu Val Arg Cys Pro Lys Ser Leu Tyr 
305                 310                 315                 320 


Glu Arg Leu Arg Glu Lys Asp Arg Glu Ser Phe Lys Val Pro Phe Asp 
                325                 330                 335     


Ile Phe Ser Asp Asp Tyr Asp Ala Glu Glu Glu Pro Phe Lys Asn Thr 
            340                 345                 350         


Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe 
        355                 360                 365             


Asp Leu Asn Glu Ile Phe Glu Gln Leu Arg Phe Gln Ile Asp Leu Gly 
    370                 375                 380                 


Thr Tyr His Phe Ser Ile Tyr Asn Lys Arg Ile Gly Asp Glu Asp Glu 
385                 390                 395                 400 


Val Arg His Leu Thr His His Leu Tyr Gly Phe Ala Arg Ile Gln Asp 
                405                 410                 415     


Phe Ala Pro Gln Asn Gln Pro Glu Glu Trp Arg Lys Leu Val Lys Asp 
            420                 425                 430         


Leu Asp His Phe Glu Thr Ser Gln Lys Pro Tyr Ile Ser Lys Thr Ala 
        435                 440                 445             


Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Lys Phe Cys Ser 
    450                 455                 460                 


Thr His Asn Asn Leu Phe Pro Ser Leu Lys Arg Glu Lys Thr Cys Asn 
465                 470                 475                 480 


Gly Arg Ser Lys Phe Asn Leu Gly Thr Gln Phe Thr Ala Glu Ala Phe 
                485                 490                 495     


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu 
            500                 505                 510         


Thr Lys Asp His Pro Lys Gly Glu Gly Val Asn Lys Ile Glu Lys Ile 
        515                 520                 525             


Ile Arg Thr Glu Ile Ser Asn Ile Tyr Asp Ile Tyr Asp Ala Phe Ala 
    530                 535                 540                 


Asn Gly Glu Ile Asn Ser Ile Ala Asp Leu Thr Cys Arg Leu Gln Lys 
545                 550                 555                 560 


Thr Asn Ile Leu Gln Gly His Leu Pro Lys Gln Met Ile Ser Ile Leu 
                565                 570                 575     


Glu Gly Arg Gln Lys Asp Met Glu Lys Glu Ala Glu Arg Lys Ile Gly 
            580                 585                 590         


Glu Met Ile Asp Asp Thr Gln Arg Arg Leu Asp Leu Leu Cys Lys Gln 
        595                 600                 605             


Thr Asn Gln Lys Ile Arg Ile Gly Lys Arg Asn Ala Gly Leu Leu Lys 
    610                 615                 620                 


Ser Gly Lys Ile Ala Asp Trp Leu Val Asn Asp Met Met Arg Phe Gln 
625                 630                 635                 640 


Pro Val Gln Lys Asp Gln Asn Asn Ile Pro Ile Asn Asn Ser Lys Ala 
                645                 650                 655     


Asn Ser Thr Glu Tyr Arg Met Leu Gln Arg Ala Leu Ala Leu Phe Gly 
            660                 665                 670         


Ser Glu Asn Phe Arg Leu Lys Ala Tyr Phe Asn Gln Met Asn Leu Val 
        675                 680                 685             


Gly Asn Asp Asn Pro His Pro Phe Leu Ala Glu Thr Gln Trp Glu His 
    690                 695                 700                 


Gln Thr Asn Ile Leu Ser Phe Tyr Arg Asn Tyr Leu Glu Ala Arg Lys 
705                 710                 715                 720 


Lys Tyr Leu Lys Gly Leu Lys Pro Gln Asn Trp Lys Gln Tyr Gln His 
                725                 730                 735     


Phe Leu Ile Leu Lys Val Gln Lys Thr Asn Arg Asn Thr Leu Val Thr 
            740                 745                 750         


Gly Trp Lys Asn Ser Phe Asn Leu Pro Arg Gly Ile Phe Thr Lys Pro 
        755                 760                 765             


Ile Arg Glu Trp Phe Glu Lys His Asn Asn Ser Lys Arg Ile Tyr Asp 
    770                 775                 780                 


Gln Ile Leu Ser Phe Asp Arg Val Gly Phe Val Ala Lys Ala Ile Pro 
785                 790                 795                 800 


Leu Tyr Phe Thr Glu Glu Tyr Lys Asp Asn Val Gln Pro Phe Tyr Asp 
                805                 810                 815     


Tyr Pro Phe Asn Ile Gly Asn Lys Leu Lys Pro Lys Lys Gly Gln Phe 
            820                 825                 830         


Leu Asp Lys Lys Glu Arg Val Glu Leu Trp Gln Lys Asn Lys Glu Leu 
        835                 840                 845             


Phe Lys Asn Tyr Pro Ser Glu Lys Lys Lys Thr Asp Leu Ala Tyr Leu 
    850                 855                 860                 


Asp Phe Leu Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys 
865                 870                 875                 880 


Asn Gln Asp Ile Val Thr Trp Leu Met Phe Lys Glu Leu Phe Asn Met 
                885                 890                 895     


Ala Thr Val Glu Gly Leu Lys Ile Gly Glu Ile His Leu Arg Asp Ile 
            900                 905                 910         


Asp Thr Asn Thr Ala Lys Ala Glu Ser Asn Asn Ile Leu Asn Arg Ile 
        915                 920                 925             


Met Pro Met Lys Leu Pro Val Lys Thr Tyr Glu Ile Asn Asn Lys Gly 
    930                 935                 940                 


Lys Met Glu Met Glu Lys Pro Leu Ala Thr Phe Tyr Ile Glu Glu Thr 
945                 950                 955                 960 


Glu Thr Lys Val Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys Asp 
                965                 970                 975     


Arg Arg Leu Asn Gly Leu Phe Ser Phe Ala Glu Thr Thr Asp Leu Asn 
            980                 985                 990         


Leu Glu Glu His Pro Ile Ser Lys  Leu Ser Val Asp His  Glu Leu Ile 
        995                 1000                 1005             


Lys Tyr  Gln Thr Thr Arg Val  Arg Ile Phe Glu Met  Ile Leu Arg 
    1010                 1015                 1020             


Leu Glu  Lys Lys Leu Ile Asn  Lys Tyr Pro Thr Leu  Pro Thr Tyr 
    1025                 1030                 1035             


Ser Phe  Lys Asn Met Leu Glu  Ser Trp Leu Glu Asp  Lys Thr Asn 
    1040                 1045                 1050             


Ser Ala  Glu Leu Asn Asn Tyr  Val Asp Cys Leu Ile  Ala Val Arg 
    1055                 1060                 1065             


Asn Ala  Phe Ala His Asn Gln  Tyr Pro Met Tyr Asn  Pro Lys Leu 
    1070                 1075                 1080             


Phe Ala  Glu Val Lys Lys Phe  Ser Leu Phe Pro Ser  Ser Asn Thr 
    1085                 1090                 1095             


Lys Lys  Ile Glu Leu Asn Ile  Ala Pro Gln Leu Leu  Glu Ile Val 
    1100                 1105                 1110             


Gly Lys  Ala Ile Lys Glu Ile  Glu Lys Ser Glu Asn  Lys Asn 
    1115                 1120                 1125         


<210>  2459
<211>  1294
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2459

Met Cys Ile Phe Ala Lys Leu Asn Ile Gln Met Pro Ser Asn Asn Asn 
1               5                   10                  15      


Ser Leu Asn Gln Phe Ile Thr Thr Met Asp Asn Asn Glu Thr Ser Ile 
            20                  25                  30          


Lys Gln Phe Val Leu Leu Gly Glu Asp Asn Ser Gln Tyr Arg Asp Tyr 
        35                  40                  45              


Ala Gly Ser Tyr Phe Thr Lys Ala Asn Leu Asn Phe Tyr Arg Thr Met 
    50                  55                  60                  


Lys Thr Val Phe Arg Arg Ser Gly Ile Met Lys Asp Asn Arg Leu Gly 
65                  70                  75                  80  


Asn Val Glu Trp Arg Asp Asp Asn Met Glu Thr Ala Leu Ser Ser Phe 
                85                  90                  95      


Asp Ile Thr Thr Ile Ser Ala Thr Gln Met Ser Ser Leu Ser Asp His 
            100                 105                 110         


Leu Phe Arg Asn Leu Pro Met Phe Gly Pro Ile Met Ser His Asp Lys 
        115                 120                 125             


Asn Ala Phe Leu Ser Pro Leu Lys Arg Ala Lys Lys Ala Leu Asp Lys 
    130                 135                 140                 


Ala Lys Lys Asp Leu Lys Asn Ala Lys Lys Ala His Gln Asp Glu Asp 
145                 150                 155                 160 


Lys Tyr Glu Lys Leu Lys Asn Val Ala Glu Ile Glu Tyr Asn Gln Gln 
                165                 170                 175     


Lys Glu Asn Phe Lys Asn Glu Met Tyr Gly Thr Glu Ala Lys Asp Met 
            180                 185                 190         


Trp Asp Lys Leu Ile Asn Ile Ala Gly Ala Leu Leu Tyr Tyr Arg Asn 
        195                 200                 205             


Leu Tyr Thr His Lys Asn Pro Tyr Ser Thr Glu Asp Asp Glu Asn Lys 
    210                 215                 220                 


Gln Lys Glu Arg Glu Ile Lys Ile Ala Lys Trp Met Asn Ser Val Phe 
225                 230                 235                 240 


Glu Gly Glu Lys Gly Ile Leu Ile Glu Arg Lys Lys Tyr Lys Tyr Glu 
                245                 250                 255     


Asp Thr Leu Phe Leu Ile Asp His Gln Lys Glu Thr Asp Arg Met Glu 
            260                 265                 270         


Lys Arg Gly Asn Lys Tyr Val Glu Arg Asp Asn Phe Tyr Phe Lys Ile 
        275                 280                 285             


Lys Ile Leu Asp Glu Asn Asn Lys Cys Ile Gly Leu Thr Asp Phe Gly 
    290                 295                 300                 


Arg Phe Phe Phe Cys Ser Leu Phe Leu Arg Arg Ser Asp Ser Glu Leu 
305                 310                 315                 320 


Tyr Ala Lys Ser Val Lys Leu Phe Glu Asn Ser Pro Tyr Cys Leu Thr 
                325                 330                 335     


Glu Gln Glu Leu Lys Ile Lys Gln Ala Glu Glu Asn Lys Arg Ala Ala 
            340                 345                 350         


Thr Glu Ser Gln Lys Ser Asp His Gln Val Asn Pro Lys Thr Ile Asp 
        355                 360                 365             


Ile Thr Glu Ser Ala Gln Ile Asn Ile Ile Arg Glu Met Met Gln Met 
    370                 375                 380                 


His Arg Ile Arg Ile Pro Arg Glu Lys Lys Ile Asp Phe Thr Pro Ser 
385                 390                 395                 400 


Glu Ser Met Leu Leu Met Asp Ile Leu Asn Glu Leu Arg Arg Cys Pro 
                405                 410                 415     


Gln Glu Leu Tyr Asp Thr Phe Asn Gln Thr Asp Lys Leu Lys Phe Val 
            420                 425                 430         


Val Asp Asn Pro Asn Glu Asp Pro Glu Ser Asp Ser Lys Ile Thr Leu 
        435                 440                 445             


Thr Arg Ser Lys Asp Arg Phe Ala His Leu Ala Leu Arg Leu Ile Asp 
    450                 455                 460                 


His Thr Asp Ala Leu Gly Ser Ile Arg Phe His Leu Arg Leu Gly Leu 
465                 470                 475                 480 


Phe Arg Phe Arg Phe Tyr Asp Lys Lys Leu Ile Asp Asn Ser Glu Thr 
                485                 490                 495     


Leu Arg Arg Val His Lys Glu Ile Asn Gly Phe Gly Lys Trp His Val 
            500                 505                 510         


Val Glu Ser Leu Arg Arg Glu Lys Trp Gly Lys Tyr Asn Gln Lys Phe 
        515                 520                 525             


Glu Leu Asn Asp Asp Gly Leu Leu Gln Phe Val Pro Asp Ser Ala Glu 
    530                 535                 540                 


Ser Asp Pro Tyr Ile Thr Asp Trp Gln Thr Thr Tyr Asn Ile His Ala 
545                 550                 555                 560 


Asn Arg Ile Gly Leu Phe Trp Asn Gly Asn Ser Gln Ser Glu Asp Tyr 
                565                 570                 575     


Tyr Ile Pro Glu Leu Lys Thr Met Val Asp Glu Asn Ser Lys Val Ile 
            580                 585                 590         


Ala Pro Val Glu Met Lys Ile Pro Leu Cys Ser Leu Ser Ile Tyr Asp 
        595                 600                 605             


Leu Pro Ala Ile Leu Phe Tyr Thr Tyr Ile Phe Asn Leu Tyr Asn Gly 
    610                 615                 620                 


Asn Arg Leu Gly Leu Pro Asn Ala Glu Lys Ile Ile Lys Asn Lys Tyr 
625                 630                 635                 640 


Thr Ala Leu Asn Glu Phe Phe Gly Phe Ala Lys Lys Ser Glu Ser Thr 
                645                 650                 655     


Pro Glu Glu Leu Ile Lys Lys Gln Glu Glu Leu Asn Leu His Asp Ser 
            660                 665                 670         


Glu Ile Pro Glu Arg Leu Leu Tyr Leu Met Gly Lys Ile Lys Thr Pro 
        675                 680                 685             


Lys Gly Lys Ile Ala Glu Trp Lys Pro Asn Ser Lys Arg Asn Asn His 
    690                 695                 700                 


Ala Lys Glu Leu Leu Lys Lys Ile Ile Glu Glu Asp Glu Trp Arg Ile 
705                 710                 715                 720 


Lys Ser Phe Lys Asp Lys Lys Asn Lys Ile Glu Asp Lys Asn Arg Tyr 
                725                 730                 735     


Gly Arg Lys Asp Tyr Ser Asp Ile Arg His Gly Val Leu Ala Lys Tyr 
            740                 745                 750         


Leu Val Glu Ser Met Met Met Trp Gln Pro Gly Lys Gln Lys Ala Glu 
        755                 760                 765             


Thr Lys Ile Ser Ser Ala Asn Tyr Arg Ala Leu Arg Asp Tyr Leu Ser 
    770                 775                 780                 


Asn Tyr Asn Asn Asn Ser Asn Asn Leu Gln Phe Val Leu Lys Ala Ala 
785                 790                 795                 800 


His Leu Ile Asp Ser Glu Asn Pro His Pro Phe Ile Asn Lys Val Lys 
                805                 810                 815     


Gly Ser Asn Ile Glu Leu Tyr Tyr Thr Asn Tyr Leu His Glu Glu Leu 
            820                 825                 830         


Lys His Ala Arg Gly Ile Leu Ser Glu Leu Glu Asp Asn Asn Tyr Thr 
        835                 840                 845             


Gly Asp Lys Lys Glu Ile Ile Pro Pro Phe Ala Lys Pro Glu Ser Asp 
    850                 855                 860                 


Lys Trp Asn Lys Lys Ser Asn Thr Ile Gln Ser Cys Ala Ala Lys Tyr 
865                 870                 875                 880 


Leu Glu His Pro Ile Gln Leu Pro Asp Gly Leu Phe Thr Gln Ala Ile 
                885                 890                 895     


Ile Asp Leu Leu Lys Ala Ala Asp Ile Asp Glu Thr Ile Lys Asn Asp 
            900                 905                 910         


Ala Thr Lys Asp Ser Asn Ala Thr Tyr Ile Ile Arg Tyr Trp Phe Asp 
        915                 920                 925             


Lys Val Gly Gln Asp Ser Pro Gln Leu Phe Tyr Asp Ser Thr Leu Phe 
    930                 935                 940                 


Lys Arg Ser Tyr Lys Phe Ile Asp Lys Cys Phe Leu Gln Lys Asp Glu 
945                 950                 955                 960 


Gly Asn Gln Thr Ile Lys His Phe Leu Thr Glu Lys Glu Ile Leu Asp 
                965                 970                 975     


Asn Ile Lys Asn Phe Arg Gly Glu Thr Gly Ser Leu Ala Gly Lys Leu 
            980                 985                 990         


Tyr Pro Lys Asp Lys Leu Glu Glu  Ser Lys Lys Ser Ile  Ile Asn Gln 
        995                 1000                 1005             


Leu Asn  Glu Val Lys Asp Lys  Glu Lys Ala Ile Arg  Arg Tyr Arg 
    1010                 1015                 1020             


Val Gln  Asp Ile Ala Leu Phe  Leu Leu Ala Arg Lys  Arg Leu Val 
    1025                 1030                 1035             


Glu Leu  Leu Ser Lys Ser Glu  Asn Ser Asn Arg Asn  Glu Ala Arg 
    1040                 1045                 1050             


Val Glu  Thr Thr His Ser Gln  Asn Asn Ile Ser Lys  Lys Ala Asn 
    1055                 1060                 1065             


Asn Leu  Lys Leu Lys Asp Phe  Gly Phe Asp Glu Asp  Phe His Phe 
    1070                 1075                 1080             


Leu Ser  Gly Ser Glu Asp Asn  Gly Asp Gly Leu Leu  Phe Glu Tyr 
    1085                 1090                 1095             


Glu Tyr  Ile Val Asp Asn Asp  Ala Asn Lys Lys Ile  Met Ile Val 
    1100                 1105                 1110             


Gln Glu  Gly Leu Ser Leu Lys  Asn Tyr Gly Asn Ile  Tyr Arg Val 
    1115                 1120                 1125             


Leu Gly  Asp Asn Arg Ile Lys  Thr Leu Met Gln Leu  Leu Tyr Glu 
    1130                 1135                 1140             


Ile Lys  Lys Asp Lys Val Glu  Asp Gly Thr Ile Thr  Phe Thr Phe 
    1145                 1150                 1155             


Ala Glu  Leu Val Lys Glu Leu  Thr Asn Asn Asp Lys  Leu His His 
    1160                 1165                 1170             


Glu Phe  Tyr Arg Leu Phe Gln  Asn Ile Glu Gln Glu  Ala Tyr Asp 
    1175                 1180                 1185             


Gly Thr  Gly Gly Phe Asp Ala  Asn Lys Lys Asn Lys  Glu Val Leu 
    1190                 1195                 1200             


Asp Asn  Pro Asp Asp Glu Gln  Phe Phe Phe Val Arg  Gln Arg Lys 
    1205                 1210                 1215             


Asn Gly  Glu Val Thr Thr Lys  Glu Ala Val Arg Asn  Ser Phe Lys 
    1220                 1225                 1230             


Lys Leu  Ile Glu Leu Leu Lys  Gln Tyr Ser Thr Asp  Glu Gly Ile 
    1235                 1240                 1245             


Ile Val  Gln Leu Arg Asn Asp  Ala Ile His Asp Arg  Tyr Pro Glu 
    1250                 1255                 1260             


Pro Ile  Ala Glu Met Glu Leu  Lys Glu Thr Gly Ile  Thr Glu Ser 
    1265                 1270                 1275             


Leu Ile  Glu Tyr Leu Asn Asn  Leu Ile Lys Lys Asn  Gln Glu Gln 
    1280                 1285                 1290             


Leu 
    


<210>  2460
<211>  1272
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2460

Met Gly Lys Asn Asn His Tyr Gly Lys Lys Pro Asn Asp Ser Val Lys 
1               5                   10                  15      


Pro Gln Gln Lys Ala Asn Gln Asn Asn Gly Ser Asn Gln Gln Val Asn 
            20                  25                  30          


Asn Ala Pro Ser Tyr Pro Ser Leu Leu Glu Ala Pro Lys Leu Ile Ser 
        35                  40                  45              


Thr Ser Asn Asn Leu Arg Pro Ile Tyr Ala Ala Tyr Leu Asn Met Ala 
    50                  55                  60                  


Arg Gln Asn Leu Tyr Asn Val Leu Gln His Val Ser Val Leu Val Gly 
65                  70                  75                  80  


Tyr Asp Asn Lys Cys Asp Glu Glu Ala Met Lys Gln Met Lys Val Ile 
                85                  90                  95      


Asn Phe Ala Lys Glu Lys Ser Glu Lys Arg Ile Arg Ile Gln Lys Glu 
            100                 105                 110         


Leu Leu Tyr Ala Ile Pro Val Leu Arg Gln Met Leu Ser Val Asp Val 
        115                 120                 125             


Asp Glu Glu Lys Lys Thr Ile Thr Asp Glu Asp Val Gln Ser Leu Leu 
    130                 135                 140                 


Lys Asn Ile Val Ser Thr Ile Phe Asp Leu Arg Asn Phe Tyr Thr His 
145                 150                 155                 160 


Tyr Lys Pro Tyr Asn Ser Pro Glu Glu Ile Ser Phe Gln Lys Glu Thr 
                165                 170                 175     


Glu Arg Ala Leu Phe Pro Tyr Ile Asp Lys Ala Phe Asp Ser Ala Lys 
            180                 185                 190         


Arg Lys Val Glu Ala Ile Trp Asp Tyr Asn Lys Lys Asp Leu Arg Phe 
        195                 200                 205             


Tyr Glu Gly Ser Glu Arg Met Thr Val Thr Arg Lys Gly Lys Lys Lys 
    210                 215                 220                 


Ala Gln Lys Arg Val Lys Phe Phe Phe Asn Pro Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Ser Ala Leu Ser Ala Val Gly Ile Ala Phe Leu Ile Cys Lys Leu Leu 
                245                 250                 255     


Pro Lys Gln Tyr Ser Thr Gln Phe Leu Gln Gln Ile Lys Leu Phe Glu 
            260                 265                 270         


Arg Ser Pro Tyr Lys Lys Glu His Pro Ile Phe Gly Lys Ala Asn Glu 
        275                 280                 285             


Val Met Tyr Asn Met Phe Cys Ile Asp His Ile Arg Leu Pro Lys Gly 
    290                 295                 300                 


Arg Met Glu Ser Ile Ala Asp Glu Thr Ile Leu Gly Leu Asp Met Ile 
305                 310                 315                 320 


Asn Glu Leu Arg Lys Cys Pro Phe Glu Leu Phe Lys Val Leu Ser Glu 
                325                 330                 335     


Lys Asp Gln Lys Leu Phe Glu Val Glu Ala Lys Glu Asn Glu Pro Gly 
            340                 345                 350         


Glu Lys Glu Pro Ala Val Thr Gln Leu Asn Leu Met Arg Arg Tyr Lys 
        355                 360                 365             


Asp Arg Phe Ser Tyr Leu Ala Leu Arg Tyr Ile Asp Phe Gln Lys Asp 
    370                 375                 380                 


Ile Leu Pro Gly Met Ala Phe Gln Val Ala Leu Gly Thr Tyr Arg Tyr 
385                 390                 395                 400 


His Phe Tyr Asp Lys Lys Asn Cys Ile Asp Gly Gly Glu Pro Arg Val 
                405                 410                 415     


Arg Ile Trp Gln Lys Glu Ile Asn Gly Phe Gly Arg Leu Pro Gln Ile 
            420                 425                 430         


Glu Ala Glu Arg Lys Arg Lys Tyr Gly Lys Lys Glu Asp Gly Ser Lys 
        435                 440                 445             


Gly Val Phe Ile Arg Pro Phe Asp Glu Val Thr Val Asp Thr Ala Glu 
    450                 455                 460                 


Thr Glu Pro Tyr Ile Thr Asp Arg His Ala Gly Tyr Ala Ile Thr Gly 
465                 470                 475                 480 


Asn Arg Ile Gly Ile Met Trp His Asp Asp Lys His Glu Asp Phe Lys 
                485                 490                 495     


Asn Asn Gln Tyr Leu Pro Glu Leu Pro Leu Pro Ser Val Gln Thr Glu 
            500                 505                 510         


Asn Gly Glu Lys Val Gly Ala Lys Val Ser Ile Lys Asn Leu Glu Pro 
        515                 520                 525             


Ile Cys Trp Leu Ser Thr Phe Asp Leu Pro Gly Leu Ile Phe Leu His 
    530                 535                 540                 


Leu Leu Gly Gly Lys Pro Asp Thr Val Ile Lys Ser Lys Tyr Glu Ser 
545                 550                 555                 560 


Leu Lys Lys Leu Leu Asn Tyr Ile Lys Gly Asp Glu Phe Val Asp Leu 
                565                 570                 575     


Tyr Lys Asn Glu Ile Ala Ala His Ile Glu Lys Tyr Asp Ser Ala Gly 
            580                 585                 590         


Leu Ser Lys Glu Glu Glu Thr Leu Leu Arg Lys Arg Leu Lys Ala Gln 
        595                 600                 605             


Leu Glu Pro Ile Val Phe Ser Lys Phe Asn Leu His Val Asn Asp Leu 
    610                 615                 620                 


Pro Glu Met Ile Thr Asp Ile Leu Ile Gly Lys Thr Gly His Asp Glu 
625                 630                 635                 640 


Gln Thr Glu Lys Asp His Ala Glu Lys Arg Phe Asn Glu Trp Ala Arg 
                645                 650                 655     


Asn Lys Val Glu Lys Met Ile Glu Ser Leu Glu Arg Arg Ile Lys Gly 
            660                 665                 670         


Phe Glu Lys Asp Leu Glu Lys Val Gly Thr Lys Ala Asn Arg Val Gly 
        675                 680                 685             


Lys Asp Asn Phe Val Asp Ile Arg Pro Gly Ser Leu Ala Arg Tyr Leu 
    690                 695                 700                 


Ala Lys Asp Ile Met Gly Phe Gln Pro Thr Ile Ala Asp Glu Asp Lys 
705                 710                 715                 720 


Arg Gly Thr Asp Lys Leu Thr Gly Leu Asn Phe Gln Ile Met Gln Ser 
                725                 730                 735     


Ala Ile Ala Thr Phe Glu Gly Asn Ser Leu Gln Gly Thr Gln Thr Pro 
            740                 745                 750         


Leu Trp Gln Leu Phe Lys Arg Ala Asn Leu Leu Ala Lys Asp Val Asn 
        755                 760                 765             


Gly Asp Lys Asn Pro Gln Lys His Pro Phe Leu Asn Asp Val Met Ser 
    770                 775                 780                 


Ser Thr Leu Lys Asp Thr Val Asp Leu Tyr Arg Arg Tyr Gln Glu His 
785                 790                 795                 800 


Lys Leu Lys Tyr Leu Arg Lys Ile Leu Glu Glu Asn Asn Phe Lys Glu 
                805                 810                 815     


Ala Tyr Phe Leu His Gly Asn Arg Lys Arg Tyr Ala Pro Lys Thr Leu 
            820                 825                 830         


Glu Ala Val Arg Ser Leu Ala Glu Arg Tyr Leu Asn Thr Leu Tyr Leu 
        835                 840                 845             


Pro Asp Gly Leu Phe Ala Glu Glu Ile Asn Lys Val Leu Lys Asp Lys 
    850                 855                 860                 


Tyr Lys Asp Asn Lys Ser Ile Gln Glu Ala Phe Gln Asp Pro Lys Gln 
865                 870                 875                 880 


Lys Tyr Asn Ile Ala Tyr Leu Leu Asn Val Tyr Phe Glu Gln Val His 
                885                 890                 895     


Lys Asp Cys Cys Gln Pro Phe Tyr Tyr Ser Arg Asn Gly Met Phe Lys 
            900                 905                 910         


Arg Asn Tyr Glu Leu Phe Asn Thr Leu Ala Ser Ser Lys Asn Asn Lys 
        915                 920                 925             


Val Val Lys Trp Tyr Thr Val Asp Glu Met Asn Asp Leu Thr Lys Lys 
    930                 935                 940                 


Gly Ser Gln Asp Met Ser Ile Ala Lys Arg Lys Ile Glu Glu Tyr Leu 
945                 950                 955                 960 


Asp Asn Tyr Met Val Lys Asp Glu Ile Asp Asp Thr Glu Arg Leu Ala 
                965                 970                 975     


Thr Glu Glu Glu Lys Thr Arg Lys Arg Arg Phe Leu Ile Ser Leu Leu 
            980                 985                 990         


Asn Asp Cys Lys Lys Asn Glu Lys  Ile Ile Arg Arg Tyr  Lys Thr Glu 
        995                 1000                 1005             


Asp Ile  Leu Leu Phe Leu Met  Ala Lys Lys Ile Leu  Val Gly Lys 
    1010                 1015                 1020             


Leu Lys  Thr Gln Lys Gly Arg  Thr Ile Glu Gln Ser  Glu Phe Asn 
    1025                 1030                 1035             


Glu Phe  Lys Leu Ser Ala Ile  Pro Ala Phe Lys Arg  Ala Gln Lys 
    1040                 1045                 1050             


Gln Gly  Glu Glu Glu Lys Glu  Tyr Lys Glu Leu Asn  Asp Asn Arg 
    1055                 1060                 1065             


Asp Ile  Leu Ser Lys Phe Ile  Asp Phe Asn Val Glu  Ile Val Leu 
    1070                 1075                 1080             


Arg Asp  Glu Lys Gly Arg Glu  Ile Leu Asp Asp Lys  Gly Thr Pro 
    1085                 1090                 1095             


Ile Arg  Lys Lys Val Tyr Gln  Glu His Leu Gln Leu  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Asp  Phe Tyr Arg Phe Leu  Tyr Asp Thr Arg Ile  Gly Leu Leu 
    1115                 1120                 1125             


Leu Lys  Gln Leu Thr Ser Glu  Cys Ile Lys Arg Glu  Asp Ile Asp 
    1130                 1135                 1140             


Asp Glu  Leu Asp Glu Tyr Asp  Arg Asn Arg Lys Glu  Ile Phe Ala 
    1145                 1150                 1155             


Lys Ile  His Ala Ile Glu Lys  Leu Ile Ile Asn Ala  His Ala Asp 
    1160                 1165                 1170             


Gln Leu  Asp Asp Ser Asn Ala  Gly Lys Glu Gly Phe  Val Asn Glu 
    1175                 1180                 1185             


Asp Gly  Glu Pro Tyr Arg Thr  Asn Phe Arg Ser Leu  Leu Ser Leu 
    1190                 1195                 1200             


Val Glu  Ser Ile Arg Ile Asp  Arg Lys Lys Leu Thr  Lys Glu Gly 
    1205                 1210                 1215             


Glu Leu  Ile Val Glu Thr Arg  Asn Ala Phe Ser His  Asn Lys Tyr 
    1220                 1225                 1230             


Ile Glu  Gln Leu Lys Asp Ile  Ala Asp Glu Lys Gly  Leu Thr Leu 
    1235                 1240                 1245             


Pro Glu  Val Ala Lys Leu Ile  Leu Ala Asn Leu Asn  Arg Phe Ala 
    1250                 1255                 1260             


Ile Lys  Leu Gly Ile Ala Thr  Lys Lys 
    1265                 1270         


<210>  2461
<211>  1403
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2461

Met Gly Lys Asn Lys Gln Lys Lys Lys Ile Gln Ser Gln Asp Ser Ser 
1               5                   10                  15      


Lys Ala Asn Asn Pro Tyr Pro Ser Val Thr Lys Pro Gln Arg Pro Asp 
            20                  25                  30          


Phe Cys Leu Glu Gly Phe Tyr Thr Gln Gln Ala Phe Val Asp Val Arg 
        35                  40                  45              


His Val Ala Ala Asn Tyr Phe Asn Leu Ala His Asn Asn Phe Tyr Lys 
    50                  55                  60                  


Thr Leu Ile Tyr Val Leu Thr Arg Ser Gly Ile Asp Leu Lys Thr Leu 
65                  70                  75                  80  


Asn Phe Trp Asn Phe Lys Asp Asp Ser Ile Gly Thr Val Leu Gln Thr 
                85                  90                  95      


Val Cys Asp Ala Thr Phe Gly Ser Gly Glu Gln Lys Gln Ala Ile Lys 
            100                 105                 110         


Asp Tyr Tyr Phe Ser Ile Glu Glu Lys Lys Leu Ile Val Glu Asn Asn 
        115                 120                 125             


Lys Glu Asn Asp Ser Asn Lys Lys Lys Ser Asp Ala Glu Ile Arg Glu 
    130                 135                 140                 


Leu Ser Leu Gln Arg Ala Glu Lys Asp Phe Gly Ser Phe Val Leu Phe 
145                 150                 155                 160 


Glu Asp Met Gln Gly Arg Ile Gln Lys Lys Leu Phe His His Ile Pro 
                165                 170                 175     


Ala Phe Gly Pro Ile Met Ala Asp Val Ala Ser Tyr Glu Ala Tyr Lys 
            180                 185                 190         


Asn Arg Gln Lys Ser Asp Glu Leu Lys Asp Lys Asn Lys Glu Lys Ile 
        195                 200                 205             


Leu Arg Gly Ile Thr Phe Gln Gln Cys Leu Glu Thr Leu Ile Ile Ile 
    210                 215                 220                 


Ala Asn Ala Leu Asn Tyr Tyr Arg Asn Phe Tyr Thr His Glu Ile Pro 
225                 230                 235                 240 


Tyr Asn Glu Leu Glu Glu Glu Trp Ser Gln Thr Leu Arg Glu Ala Lys 
                245                 250                 255     


Leu Val Lys Tyr Met Asn Asn Val Phe Lys Ala Ser Gln Arg Leu Asp 
            260                 265                 270         


Lys Lys Arg Glu Leu Val Thr Thr Glu Ala Met Thr Phe Leu Thr Gly 
        275                 280                 285             


His Gly Ser Gly Asp Pro Cys Asp Arg Met Lys Glu Ile Pro Asn Gly 
    290                 295                 300                 


Glu Lys Thr Tyr Phe Asp Glu Lys Lys His Arg Asn Val Thr Ile Lys 
305                 310                 315                 320 


Val Tyr Arg Tyr Glu Glu Asn Glu Asn Phe Phe Phe Lys Ile Ala Gly 
                325                 330                 335     


Arg Glu Phe Thr Thr Glu Asp Gly Gly Lys Ala Asn Tyr Leu Ser Asp 
            340                 345                 350         


Phe Gly Lys Leu Leu Phe Cys Cys Leu Phe Leu Lys Arg Gln Gln Thr 
        355                 360                 365             


Gln Asn Phe Ala Ile Glu Ser Arg Leu Leu Glu Phe Ser Pro Tyr Leu 
    370                 375                 380                 


Leu Lys Pro His Glu Leu Gln Lys Lys Gln Ala Glu Glu Asn Lys Arg 
385                 390                 395                 400 


Val Asp Lys Glu Asn Lys Leu Arg Gln Ala Gln Gly Lys Lys Arg Met 
                405                 410                 415     


Leu Thr Pro Lys Gln Phe Thr Lys His Asp Ser Leu Gln Asn Glu Ile 
            420                 425                 430         


Ile Leu Asp Met Leu Gly Ile Tyr His Ile Arg Arg Pro Leu Glu Lys 
        435                 440                 445             


Arg Ile Asp Ala Lys Ala Thr Pro Gly Thr Leu Ala Met Asp Met Leu 
    450                 455                 460                 


Asn Glu Leu Arg Arg Cys Pro Ser Glu Leu Tyr Gln Thr Phe Ser Ala 
465                 470                 475                 480 


Asp Asp Lys Asp Ile Phe Glu Arg Glu Val Ser Asp Pro Lys Asp Gly 
                485                 490                 495     


Ser Pro Arg Ser Ala Lys Ala Glu Glu Lys Val Lys Leu Ile Arg Tyr 
            500                 505                 510         


Thr Asp Arg Phe Pro Tyr Leu Ala Leu Arg Tyr Ile Asp Glu Thr Asn 
        515                 520                 525             


Leu Ile Gly Asp Ile Arg Phe His Ile Arg Leu Gly Asn Tyr Arg Phe 
    530                 535                 540                 


His Phe Tyr Asp Lys Thr Cys Val Asp Gly Asn Pro Lys Ile Arg Ser 
545                 550                 555                 560 


Trp Gln Lys Glu Ile Asn Gly Phe Gly Lys Trp Gln Glu Ile Glu Glu 
                565                 570                 575     


Lys Arg Lys Ser Lys Trp Ala Asn Gln Phe Gln Lys Arg Glu Tyr Val 
            580                 585                 590         


Asn Thr Arg Gln Glu Tyr Gly Glu Met Glu Leu Glu Gln Pro Val Lys 
        595                 600                 605             


Asp His Ala Asp Thr Lys Pro Tyr Ile Thr Asp Trp Thr Ala Ala Tyr 
    610                 615                 620                 


Asn Ile His Ala Asn Arg Ile Gly Leu Tyr Trp Gly Leu Glu Asp Gly 
625                 630                 635                 640 


Met Phe Leu Pro Asp Leu Asn Thr Ile Val Asp Pro Thr Asp Ala Asn 
                645                 650                 655     


Ala Ser Gln Glu Glu Leu Arg Lys Ser Glu Met Lys Pro Arg His Arg 
            660                 665                 670         


Ala Pro Val Ile Met Lys Glu Pro Leu Cys Thr Leu Ser Thr Tyr Asp 
        675                 680                 685             


Leu Pro Ala Leu Leu Phe Tyr Asn Tyr Leu Phe Lys His Tyr Asn Ala 
    690                 695                 700                 


Ala Lys Tyr Lys Met Pro Met Pro Asn Lys Ile Ile Lys Asp Ala Tyr 
705                 710                 715                 720 


Asp Gly Leu Lys Ala Phe Ile Asp Ala Ile Ala Ala Arg Lys Lys Gly 
                725                 730                 735     


Lys Asp Leu Glu Glu Val Leu Gln Gln Lys Gly Val Arg Glu Phe Asp 
            740                 745                 750         


Ile Pro Lys Ala Leu Arg Lys Arg Leu Glu Ser Gln Gly Lys Pro Glu 
        755                 760                 765             


Gln Phe Asn Asn Lys Ile Tyr Met Arg Leu Val Glu Arg Val Tyr Gly 
    770                 775                 780                 


Arg Tyr Asp Ile Glu Arg Glu Met Tyr Val Pro Gly Lys Leu Ser Glu 
785                 790                 795                 800 


Lys Leu Glu Glu Ile Glu Tyr Arg Ile Lys Ala Phe Lys Asp Lys Lys 
                805                 810                 815     


Ala Lys Ile Asp Ser Gly Asp Asn Lys Tyr Ala Lys Lys Gly Tyr Ala 
            820                 825                 830         


Asp Ile Arg His Gly Val Leu Ala Arg Tyr Leu Ala Lys Ser Phe Met 
        835                 840                 845             


Gln Trp Gln Pro Thr Lys Asp Lys Gly His Asp Lys Ile Thr Gly Leu 
    850                 855                 860                 


Asn Tyr Ser Val Met Thr Ala Phe Leu Ser Thr Tyr Gly Ile Asn Ser 
865                 870                 875                 880 


Asp Ile Val Gln Leu Arg Thr Leu Leu Glu Lys Ala Lys Leu Ile Gly 
                885                 890                 895     


Ser Ala Asn Pro His Pro Phe Leu Pro Glu Val Leu Ala Glu Ser Pro 
            900                 905                 910         


Gln Asn Ile Glu Asp Leu Tyr Phe Ile Tyr Leu Lys Gln Glu Gln Lys 
        915                 920                 925             


Phe Ala Glu Gly Leu Asn Ser His His Gly Lys Leu Lys Ala Phe Lys 
    930                 935                 940                 


Gly Asn Leu Gln Asp Lys Ile Lys Tyr Ile Asn Glu Asn Lys Ser Ser 
945                 950                 955                 960 


Ile Asp Gln Ile Leu Ala Gln Ile Pro Phe Val His Ala Asp Arg Glu 
                965                 970                 975     


Lys Trp Arg Arg Thr Asp Ser Val Asp Lys Tyr Tyr Thr Asp Tyr Ala 
            980                 985                 990         


Gly Arg Tyr His Thr Ile Met Leu  Pro Asp Ser Leu Phe  Thr Pro Tyr 
        995                 1000                 1005             


Ile Ile  Arg Leu Met Lys Ser  Cys Leu Pro Asn Asp  Lys Thr Leu 
    1010                 1015                 1020             


Met Ser  Arg Ile Lys Ala Cys  Glu Ser Asp Ser Arg  Gln Thr Leu 
    1025                 1030                 1035             


Gly Ala  Ala Trp Leu Ile Glu  Tyr Tyr Phe Glu His  His Met Lys 
    1040                 1045                 1050             


Asp Lys  His Gln Gln Phe Tyr  Asn Ala Asn Ile Phe  Arg Arg Ala 
    1055                 1060                 1065             


Tyr Lys  Pro Phe Thr Thr Met  Asn Asn Asp Phe Val  Lys Asn Gln 
    1070                 1075                 1080             


Asn Gly  Gly Asn Thr Asn Glu  Pro Leu Pro Tyr Tyr  Asn Ser Lys 
    1085                 1090                 1095             


Lys Glu  Ile Glu Glu Lys Leu  Ser Tyr Thr Glu Glu  Asp Ile Arg 
    1100                 1105                 1110             


Asn Phe  Val Tyr Asn Val Trp  Arg Gly Lys Thr Lys  Arg Glu Glu 
    1115                 1120                 1125             


Ile Glu  Ile Leu Lys Asn Gln  Ile Lys Asp Val Lys  Asp Thr Glu 
    1130                 1135                 1140             


Lys Val  Ile Arg Arg Tyr Arg  Thr Gln Asp Val Thr  Leu Phe Leu 
    1145                 1150                 1155             


Ala Ala  Lys Asp Leu Leu Thr  Thr Gln Leu Ser Lys  Asp Asp Asn 
    1160                 1165                 1170             


Met Ala  Asp Ala Thr Lys Gln  Ala Met Lys Asn Leu  Lys Glu Lys 
    1175                 1180                 1185             


Ala Glu  Cys Leu Lys Leu Lys  Asp Phe Asp Tyr Asp  Glu Gly Phe 
    1190                 1195                 1200             


Ser Phe  Leu Ser Asp Gly Asp  Asn Pro Glu Ser Gly  Ile Val Tyr 
    1205                 1210                 1215             


Thr Tyr  Glu Tyr Lys Thr Lys  Thr Gly Arg Thr Val  Lys Ile Thr 
    1220                 1225                 1230             


Gln Lys  Gly Val Ser Leu Lys  Asn Tyr Gly Asn Ile  Tyr Arg Ile 
    1235                 1240                 1245             


Leu Gly  Asp Asp Arg Phe Lys  Ser Leu Met Glu Gly  Ile Ala Asn 
    1250                 1255                 1260             


Ile Ala  Thr Thr Asp Ser Ile  Glu Val Thr Phe Asn  Asp Leu Thr 
    1265                 1270                 1275             


Thr Glu  Phe Ala Asn Tyr Asp  Glu Arg Arg Ser Ala  Met Phe Lys 
    1280                 1285                 1290             


Met Val  His Glu Leu Glu Gly  Lys Ala Phe Ile Arg  Asn Glu Lys 
    1295                 1300                 1305             


Glu Leu  Gln Asp Pro Asn Asn  Pro Val Phe His Ile  Lys Asn Asp 
    1310                 1315                 1320             


Leu Ala  Lys Asp Pro Arg Arg  Asn Asn Phe Ser Ser  Leu Leu Glu 
    1325                 1330                 1335             


Leu Leu  Gln Glu Tyr Ser Asp  Lys Asp Gln Lys Val  Met Val Ala 
    1340                 1345                 1350             


Ile Arg  Asn Ala Ile Gly His  Asp Tyr Tyr Met Asp  Ile Thr Leu 
    1355                 1360                 1365             


Leu Asp  Arg Thr Asn Ser Lys  Ala Lys Arg Val Pro  Asn Ile Ser 
    1370                 1375                 1380             


Leu Leu  Met Glu His Thr Leu  Asn Lys Lys Lys Asp  Asn Pro Ser 
    1385                 1390                 1395             


Gln Asp  Lys Lys Lys 
    1400             


<210>  2462
<211>  1126
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2462

Met Glu Thr Leu Leu Thr Pro Thr Glu Asn Lys Tyr Arg Thr Ile Asn 
1               5                   10                  15      


Asp Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Ser Met Ala Arg Leu Asn 
            20                  25                  30          


Val Phe Asn Ile Ser Asn His Ile Ala Lys Glu Phe Gly Gln Ser Leu 
        35                  40                  45              


Leu Glu Glu Glu Gly His Ile Lys Asn Ser Phe Leu Cys Asp Lys Asn 
    50                  55                  60                  


Asn Lys Lys Val Asn Trp Asn His Val His Ala Lys Ala Arg Arg Phe 
65                  70                  75                  80  


Leu Ser Ile Leu Lys Val Phe Asp Ala Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Leu Lys Ile Ile Glu Trp Glu Gly Lys Asp Phe Ser Leu Met Gly Asp 
            100                 105                 110         


Thr Leu Lys Ile Val Phe Arg Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Phe Tyr Ser Thr Glu Lys Gly Thr Ser Arg Lys Ile Lys Val 
    130                 135                 140                 


Ser Glu Glu Leu Ala Glu Phe Leu Lys Thr Asn Phe Arg Arg Ala Ile 
145                 150                 155                 160 


Glu Tyr Thr Lys Glu Arg Phe Lys Gly Gly Leu Ile Glu Glu Asp Phe 
                165                 170                 175     


Asn Leu Val Ala Ser Arg Lys Val Val Arg Asp Asp Leu Ala Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ala Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Thr Gly Leu Lys Gly Thr Gln Asn 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro His Asp Arg Phe Gln Ser Asp Asn Thr Arg Gln Ala Phe Ser 
                245                 250                 255     


Leu Asp Leu Ile Asn Glu Leu Asn Arg Cys Pro Lys Val Leu Tyr Asn 
            260                 265                 270         


Val Ile Thr Glu Glu Gly Lys Gln Leu Phe Arg Pro Gln Leu Glu Asp 
        275                 280                 285             


Leu Glu Ile Lys Asn Leu Ile Lys Asn Ser Thr Asn Asn Glu Glu Glu 
    290                 295                 300                 


Ile Asp Asn Tyr Asp Glu Tyr Ile Glu Ala Leu Thr Lys Arg Ile Arg 
305                 310                 315                 320 


His Thr Asn Arg Phe Ser Asp Phe Ala Leu Gln Phe Ile Asp Glu Thr 
                325                 330                 335     


Asp Val Phe Lys Lys Phe Arg Phe Gln Ile Asp Leu Gly Lys Leu Leu 
            340                 345                 350         


Val Asp Glu Tyr Asp Lys Ser Phe Asn Gly Glu Glu Val Glu Arg Lys 
        355                 360                 365             


Ile Ile Val Asn Ala Lys Ala Phe Arg Lys Leu Asn Ser Tyr Gly Thr 
    370                 375                 380                 


Glu Asp Glu Thr Leu Lys Leu Ile Glu Asn Gly Gln Gly Ser Lys Arg 
385                 390                 395                 400 


Phe Glu Gln Phe Ala Pro His Tyr Asn Thr Glu Asn Asn Lys Ile Gly 
                405                 410                 415     


Leu Ser Gly Lys Glu Leu Ile Ala Lys Leu Arg Pro Asn Ser Lys Gly 
            420                 425                 430         


Glu Ala Gly Lys Lys Leu His Gln Pro Leu Pro Glu Ala Phe Leu Ser 
        435                 440                 445             


Leu Lys Glu Leu Pro Lys Ile Ile Leu Leu Asn Tyr Leu Leu Pro Asp 
    450                 455                 460                 


Glu Pro Glu Lys Leu Ile Asn Asp Phe Ile Leu Val Asn Asn Ser Lys 
465                 470                 475                 480 


Leu Met Asn Met Ser Phe Ile Lys Glu Val Lys Ser Leu Leu Pro Lys 
                485                 490                 495     


Glu Trp Asn Glu Phe Lys Lys Arg Ser Asp Thr Lys Lys Gln Arg Ala 
            500                 505                 510         


Tyr Asn Glu Lys Ala Leu Ala Tyr Leu Leu His Arg Lys Gln Ile Leu 
        515                 520                 525             


Asn Gln Val Leu Ala Ala Tyr Gln Leu Asn Asp Lys Gln Ile Pro Arg 
    530                 535                 540                 


Arg Ile Leu Asp Tyr Trp Leu Asn Ile Val Asp Val Val Glu Gly Arg 
545                 550                 555                 560 


Ser Val Ser Asp Arg Ile Lys Met Met Lys Arg Asp Cys Met Ser Arg 
                565                 570                 575     


Leu Lys Ala Met Ala Lys Phe Lys Glu Asp Arg Asn Arg Asn Lys Ile 
            580                 585                 590         


Pro Lys Ile Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile Val Asp 
        595                 600                 605             


Met Val Val Gly Glu Glu Lys Lys Gln Lys Ile Thr Ser Phe Tyr Tyr 
    610                 615                 620                 


Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Pro Glu Lys Lys 
625                 630                 635                 640 


Gln Leu Phe Ile His Thr Val Ile Asn Glu Leu Lys Leu Asn Glu Gln 
                645                 650                 655     


Gly Gly His Pro Phe Leu His Lys Leu Asn Leu Gln Gln Ile Lys Asn 
            660                 665                 670         


Thr Ser Gly Phe Tyr Glu Ile Tyr Leu Gln Glu Lys Gly Gln Lys Met 
        675                 680                 685             


Val Ser Glu Lys Asn Phe Arg Thr Gly Arg Thr Ile Glu Thr Asp Lys 
    690                 695                 700                 


Ser Trp Met Ala Leu Thr Phe Tyr Lys Lys Glu Trp Asp Glu Lys Val 
705                 710                 715                 720 


Gly Lys Gln Leu Thr Val Val Arg Leu Pro Glu Asn Lys Ser Asn Ile 
                725                 730                 735     


Pro Phe Ser Leu Arg Leu Leu Glu Glu Lys Thr Val Tyr Thr Leu Glu 
            740                 745                 750         


Gln Trp Leu His Asn Val Thr Lys Gly Lys Lys Gln Asn Asp Thr Arg 
        755                 760                 765             


Gln Pro Val Asn Leu Pro Thr Asn Leu Phe Asp Glu Arg Leu Thr Val 
    770                 775                 780                 


Leu Leu Arg Gly Glu Leu Asp Lys Lys Gln Ile Ser Tyr Ala Pro Asn 
785                 790                 795                 800 


Ala Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Lys Ser Arg Asn Asp 
                805                 810                 815     


Ser Val Gln Ser Phe Tyr Lys Ala Glu Arg Glu Tyr Glu Ile Phe Gly 
            820                 825                 830         


Glu Lys Val Asn Phe Met Pro Asp Ser Lys Glu Arg Phe Ala Asp Tyr 
        835                 840                 845             


Tyr Gln His Ala Leu Thr Ala Ala Trp Gln Lys Lys Arg Lys Glu Arg 
    850                 855                 860                 


Ile Gln Gln Gln Lys Gln Asp Arg Arg Leu Pro Asp Ile Ser Phe Asp 
865                 870                 875                 880 


Gln Val Glu Lys Thr Phe Lys Gln Thr Ile Ala Glu Thr Glu Lys Glu 
                885                 890                 895     


Ile Arg Ile Val Gln Glu Glu Asp Arg Met Met Leu Leu Met Leu Glu 
            900                 905                 910         


Thr Leu Met Glu Asn Gly Lys Asp Leu Lys Leu Lys Leu Ser Gly Ile 
        915                 920                 925             


Asp Thr Leu Leu Asn Ala Thr Thr Glu Val Lys Gln Leu Val Ser Gly 
    930                 935                 940                 


Lys Leu Ser Phe Asn Gly Ser Gly Glu Leu Ile Lys Gly Lys Thr Asn 
945                 950                 955                 960 


Pro Glu Ile Ser Lys Thr Ile Thr Val Ala Arg Lys Arg Lys Asp Tyr 
                965                 970                 975     


Ser Met Leu Arg Lys Phe Val Phe Asp Arg Arg Leu Pro Glu Leu Phe 
            980                 985                 990         


Glu Tyr Phe Ala Glu Glu Glu Ile  Pro Ile Glu Val Leu  Lys Asp Glu 
        995                 1000                 1005             


Leu Asp  Ala Tyr Asn Lys Ala  Lys His Glu Val Phe  Asp Thr Val 
    1010                 1015                 1020             


Phe Glu  Leu Glu Glu Lys Ile  Ile Thr Leu Asp Ala  Asp Gly Ile 
    1025                 1030                 1035             


Arg Gln  Leu Phe Ile Asp Asp  Ala Gly Gln Pro Val  Thr Gly Asn 
    1040                 1045                 1050             


Ile Gln  His Lys Pro Tyr Val  Ile Trp Leu Lys Asn  Asn Gly Thr 
    1055                 1060                 1065             


Ile Asp  Asp Asn Thr Leu Thr  Phe Leu Asn Met Val  Arg Asn Cys 
    1070                 1075                 1080             


Phe Ser  His Asn Gln Tyr Pro  Gln Lys Lys Thr Met  Glu Leu Leu 
    1085                 1090                 1095             


Ile Gly  Gln Trp Glu Pro Asn  Arg Phe Ala Leu Thr  Ile Ala Gln 
    1100                 1105                 1110             


Thr Tyr  Lys Arg Lys Ile Asn  Ser Ile Met Lys His  Leu 
    1115                 1120                 1125     


<210>  2463
<211>  1136
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2463

Met Glu Thr Asn His Leu Gly Lys Arg Ile Glu Tyr Asn Tyr Leu Lys 
1               5                   10                  15      


Thr Ala Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Lys Asn 
            20                  25                  30          


Asn Ile Glu Val Val Phe Ser Val Phe Cys Glu Arg Phe Lys Ile Thr 
        35                  40                  45              


Pro Thr Asn Tyr Ile Ser Leu Ile Asn Asp Gln Leu Lys Asp Asp Val 
    50                  55                  60                  


Ala Pro Ser Glu Tyr Gln Lys Lys Val Asp Phe Leu Lys Gln Tyr Phe 
65                  70                  75                  80  


Pro Ala Ile His Tyr Leu Asp Leu Glu Ile Thr Asn Glu Lys Phe Ser 
                85                  90                  95      


Lys Glu Lys Asp Lys Glu Lys Ala Lys Arg Lys Tyr Phe Arg Glu Asn 
            100                 105                 110         


Phe Ile Ala Leu Ile Lys Ala Ile Gly Cys Leu Arg Asp Phe Tyr Thr 
        115                 120                 125             


His His Tyr His Lys Pro Ile Phe Phe Asp Val Asn Leu Phe Asp Leu 
    130                 135                 140                 


Leu Asp Glu Leu Leu Ile Thr Val Val Phe Asp Val Arg Lys Arg Lys 
145                 150                 155                 160 


Met Lys Gly Asp Gln Thr Arg His Leu Leu Lys Lys Gly Leu His Ser 
                165                 170                 175     


Glu Ile Glu Glu Leu Val Lys Leu Lys Thr Ile His Leu Lys Glu Gln 
            180                 185                 190         


Lys Lys Glu Gly Lys Arg Val Asn Leu Asp Ser Glu Ala Ile Glu Asn 
        195                 200                 205             


Ala Val Phe Asn Asp Ala Phe Tyr His Leu Leu Tyr Lys Glu Gly Val 
    210                 215                 220                 


Ser Arg Asn Tyr Gln Ser Lys Leu Ile Ser Glu Thr Glu Asn Glu Asn 
225                 230                 235                 240 


Asn Leu Asn Ile Ser Glu Ser Gly Leu Leu Phe Leu Leu Ser Ile Phe 
                245                 250                 255     


Leu Gln Arg Lys Glu Asn Glu Gln Leu Arg Ala Asn Ile Lys Gly Tyr 
            260                 265                 270         


Lys Gly Lys Val Ile Val Glu Asn Glu Lys Pro Ile Asp Arg Asn Asn 
        275                 280                 285             


Asn Ser Leu Lys Phe Met Ala Thr His Trp Val Phe Asn Tyr Leu Ser 
    290                 295                 300                 


Val Lys Thr Ile Lys His Arg Leu Asn Thr Thr Phe Gln Lys Glu Thr 
305                 310                 315                 320 


Leu Leu Ile Gln Ile Ala Asp Glu Leu Ser Lys Val Pro Asp Ala Leu 
                325                 330                 335     


Tyr Gln Thr Phe Thr Lys Glu Gln Lys Glu Glu Phe Val Glu Asp Val 
            340                 345                 350         


Asn Glu Tyr Leu Lys Asp Gly Asp Ser Ser Glu Ser Leu Glu Lys Ser 
        355                 360                 365             


Ile Ile Ile His Pro Val Ile Arg Lys Arg Tyr Glu Asn Lys Phe Asn 
    370                 375                 380                 


Tyr Phe Ser Leu Arg Phe Leu Asp Glu Phe Val Asn Phe Pro Ser Leu 
385                 390                 395                 400 


Arg Phe Gln Ile Tyr Leu Gly Asn Tyr Val Gln Asp Arg Arg Val Lys 
                405                 410                 415     


Pro Ile Ser Gly Thr Asn Tyr Thr Thr Glu Arg Met Ile Lys Glu Lys 
            420                 425                 430         


Ile Asn Val Phe Gly Lys Leu Ser Glu Ile Ser Gln Ile Lys Ser Asp 
        435                 440                 445             


Tyr Phe Gly Ser Ser Asn Glu Asp Thr His Trp Glu Met Phe Pro Asn 
    450                 455                 460                 


Pro Ser Tyr Asn Phe Val Gly Asn Asn Ile Pro Ile Asn Leu Glu Lys 
465                 470                 475                 480 


Ser Lys Val Lys Ser Val Gly Lys Leu Asn Gly Leu Leu Asn Gln Leu 
                485                 490                 495     


His Lys Lys Gln Lys Ile Lys Asn Arg Lys Glu Asn Lys Pro Ser Lys 
            500                 505                 510         


Thr Glu Met Ile Ser Glu Leu His Glu Gly Ile Ile Phe Gly Lys Pro 
        515                 520                 525             


Thr Ala Val Leu Ser Met Asn Glu Met Gln Ala Leu Leu His Glu Val 
    530                 535                 540                 


Leu Val Asn Asn Lys Thr Gly Glu Glu Val Glu Glu Ile Leu Ile Asn 
545                 550                 555                 560 


Lys Leu Ile Glu Arg Tyr Asp Thr Ile Ile Asn Phe Asp Pro Asn Glu 
                565                 570                 575     


Pro Leu Pro Thr Ser Lys Ile Thr Lys Lys Leu Arg Lys Ser Thr Asn 
            580                 585                 590         


Glu Ile Lys Ile Asp Ile Asp Lys Leu Leu Arg Ala Ile Glu Ser Glu 
        595                 600                 605             


Ile Arg Val Thr Asn Glu Lys Leu Cys Leu Ile Lys Asn Asn Val Gln 
    610                 615                 620                 


Glu Leu Asn Asp Arg Gln Gln Lys Arg Lys Phe Val Phe Thr Asn Lys 
625                 630                 635                 640 


Glu Leu Gly Gln Glu Ala Thr Trp Leu Ala Asp Asp Ile Lys Arg Phe 
                645                 650                 655     


Met Pro Lys Glu Thr Lys Glu Asn Trp Lys Gly Tyr Gln His Ser Leu 
            660                 665                 670         


Leu Gln Glu Leu Leu Ala Phe Tyr Glu Ser Lys Pro Lys Glu Ala His 
        675                 680                 685             


Asn Phe Leu Asn Thr His Trp Asn Ile Lys Asp Asn Asn Tyr Pro Phe 
    690                 695                 700                 


Asn Glu Trp Leu Val Lys Ala Phe Gln Asn Asn Lys Phe Asp Arg Phe 
705                 710                 715                 720 


Tyr Arg Val Tyr Leu Ser Asn Arg Val Lys Tyr Phe Glu Ser Leu Lys 
                725                 730                 735     


Thr Gln Ile Ser Gly Phe Lys Asn Asn Arg Lys Leu Leu Asn Lys Phe 
            740                 745                 750         


Leu Lys Gln Gln Phe Val Trp Ser Ile Phe Tyr Lys Arg Leu Tyr Val 
        755                 760                 765             


Ile Ser Thr Thr Glu Asn Gln Lys Glu Gln Leu Leu Leu Lys Pro Leu 
    770                 775                 780                 


Val Phe Pro Arg Gly Ile Phe Asp Glu Lys Pro Thr Tyr Ile Lys Gly 
785                 790                 795                 800 


Lys Asn Ile Val Glu Ser Pro Asn Leu Phe Ala Asp Trp Tyr Arg Phe 
                805                 810                 815     


Ile Gln Asp Lys Asn Gln Glu Leu Gln Lys Phe Tyr Leu Trp Glu Arg 
            820                 825                 830         


Asp Tyr Lys Glu Leu Phe Glu Gln His Lys Ile Ala Leu Glu Phe Ser 
        835                 840                 845             


Thr Asn Lys Tyr Asp Leu Ser Glu Ile Asp Lys Phe Asn Leu Phe Lys 
    850                 855                 860                 


Arg Lys Trp Asp Lys Lys Ile Lys Ala Thr Ile Gly Gln Asp Leu Phe 
865                 870                 875                 880 


Leu Asn Leu Met Asn Arg Lys Ile Ile Lys Asp Leu Tyr Asn His Asp 
                885                 890                 895     


Val Asp Leu Ser Leu Ser Asp Tyr Tyr Leu Thr Gln Lys Glu Arg Ile 
            900                 905                 910         


Glu Lys Gln Asn Lys Ala Leu Lys Gln Ser Gln Arg Glu Lys Gln Asp 
        915                 920                 925             


Lys Ser Glu Asn Ile Val Lys Asp Asp Phe Ile Trp Ser Met Thr Val 
    930                 935                 940                 


Ser Phe Lys Thr Glu Phe Ile Asp Glu Pro Ser Ile Lys Leu Lys Asp 
945                 950                 955                 960 


Val Gly Lys Phe Thr Arg Phe Leu Asn Glu Glu Lys Val Lys Arg Ile 
                965                 970                 975     


Phe Glu Tyr Asn Thr Ser Lys Lys Trp Thr Lys Leu Glu Ile Glu Lys 
            980                 985                 990         


Glu Leu Glu Asn Tyr Glu Lys Ile  Arg Arg Glu Glu Ile  Phe Lys Leu 
        995                 1000                 1005             


Phe Gln  Glu Leu Glu Glu Lys  Ile Leu Glu Glu Asn  Lys Phe Asp 
    1010                 1015                 1020             


Gly Val  Asn His Pro Asn Ser  Phe Met Gln Asn Gly  Asn Pro Asn 
    1025                 1030                 1035             


Phe Lys  Lys Tyr Ile Thr Gln  Gly Phe Leu Ile Lys  Asp Lys Ser 
    1040                 1045                 1050             


Leu Lys  Lys Glu Asp Val Glu  Trp Ile Glu Gly Leu  Lys Asp Lys 
    1055                 1060                 1065             


Gly Ser  Lys Asn Thr Phe Glu  Ser Asn Asp Thr Ile  Lys Glu Leu 
    1070                 1075                 1080             


Gln Gln  Lys Pro Glu Ile Ile  Lys Gln Ala Phe Met  Phe Ile Tyr 
    1085                 1090                 1095             


Leu Arg  Asn Lys Phe Ala His  Asn Gln Leu Pro Ile  Lys Thr Tyr 
    1100                 1105                 1110             


Phe Asp  Met Ile Cys Pro Asn  Phe Asp Thr Thr Lys  Ser Ile Thr 
    1115                 1120                 1125             


Glu Asn  Ile Phe Asn Tyr Leu  Lys 
    1130                 1135     


<210>  2464
<211>  1140
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2464

Met Glu Asn Asp Gln Gln Ile Leu Glu Asn Arg Arg Arg Thr Leu Ala 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Ser Asn His Leu Ala Thr Ser Phe Glu Gln Lys Ala 
        35                  40                  45              


Leu His Glu Glu Gly Gln Ile Pro Ala Ser Phe Leu Cys Asn Lys Ser 
    50                  55                  60                  


Ile Lys Lys Ile Asn Trp Asn His Val Tyr Ser Lys Ala Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Ile Phe Asp Ala Asp Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Arg Glu Thr Ser Asp Lys Glu Gly Lys Asp Phe Thr Ala Met Asn Glu 
            100                 105                 110         


Thr Leu Lys Leu Val Phe Asp Glu Leu Gln Ala Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Ala Asp Ser Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Val Glu Leu Ala Asp Phe Leu Thr Val Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Ala Asp Asp Asp Tyr 
                165                 170                 175     


Ala Val Val Glu Ser Lys Gln Ile Val Thr Pro Asp Asn Gln Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Ile Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Val Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Leu Ala Tyr Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asp Leu Arg Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Glu 
            260                 265                 270         


Val Ile Thr Glu Glu Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Glu Glu Glu Arg 
    290                 295                 300                 


Glu Lys Ile Leu Asp Glu Ile Asp Tyr Glu Asp Tyr Ile Glu Ser Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg His Ser Asn Arg Phe Pro Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Glu Lys Tyr Asn Lys Gln Phe Asp Gly Glu 
        355                 360                 365             


Ala Thr Glu Arg Lys Val Val Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asn Gln Glu Thr Val Glu Leu Lys Ile Asp Ser Ala 
385                 390                 395                 400 


Gln Arg Thr Asn Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Glu Ala Arg Leu Leu 
            420                 425                 430         


Thr Lys Ala Lys Pro Glu Ser Lys Val Ser Tyr Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Lys Ala Glu Glu Met Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Lys Val Asn Asp Ser Gln Leu Met Asn Met Gln Phe Ile Asp Glu 
                485                 490                 495     


Ile Lys Glu Gln Leu Pro Ala Asp Trp Asn Glu Phe Gly Lys Arg Ser 
            500                 505                 510         


Asp Ser Lys Lys Lys Lys Ala Tyr Thr Asn Ala Ala Arg Gln Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Lys Val Leu Ala Asn Tyr Gln Leu 
    530                 535                 540                 


Asn Asp Lys Gln Val Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Val 
545                 550                 555                 560 


Lys Glu Val Asp Asp Ser Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Met Glu Lys His Lys Val 
            580                 585                 590         


Asp Lys Ser Ala Arg Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Thr Asp Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Tyr 
625                 630                 635                 640 


Ala Asp Asn Glu Lys Lys Ala Thr Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Lys Asp Gly His Pro Phe Leu Ala Asn Ile Asn 
            660                 665                 670         


Leu Arg Gln Ile Arg Lys Thr Ser Gln Leu Tyr Glu Leu Tyr Leu Val 
        675                 680                 685             


Glu Lys Ala Asn Lys Gln Val Lys Lys Met Asn Pro Lys Thr Gln Arg 
    690                 695                 700                 


Thr Asn Asn Val Asp Glu Ser Trp Met Met Lys Ser Phe Tyr Ala Lys 
705                 710                 715                 720 


Glu Trp Asn Glu Glu Met Gly Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Thr Asn Ile Pro Phe Thr Ile Arg Gln Trp Glu Glu Lys 
            740                 745                 750         


Glu Lys His Asn Leu Gln Ala Trp Leu His Asn Ile Thr Lys Gly Lys 
        755                 760                 765             


Thr Ser Lys Asp Gly Lys Lys Ala Val Asp Leu Pro Thr Asn Leu Phe 
    770                 775                 780                 


Asp Asp Thr Leu Cys Glu Leu Leu Arg Glu Ala Leu Ile Asn Glu Gly 
785                 790                 795                 800 


Ile Asp Ala Thr Pro Thr Thr Lys Tyr Asn Glu Leu Leu Lys His Trp 
                805                 810                 815     


Trp Thr Ala Arg Glu Asp Ser Thr Gln Asp Phe Tyr Leu Ser Glu Arg 
            820                 825                 830         


Gln Tyr Asp Ile Tyr Asp Glu Lys Val Cys Phe Thr Ile Asn Ser Ser 
        835                 840                 845             


Ala His Phe Ala Asp Tyr Tyr Ala Pro Ala Leu Ser Lys Ala Tyr Ser 
    850                 855                 860                 


Arg Leu Arg Ala Glu Arg Asp Val Ala Arg Arg Thr Asp Lys Arg Leu 
865                 870                 875                 880 


Pro Pro Val Glu Arg Lys Asp Val Glu Arg Val Phe Lys Asn Thr Ile 
                885                 890                 895     


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
            900                 905                 910         


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asn Gln Gln Gln Leu Lys 
        915                 920                 925             


Leu Ser Lys Met Asp Ser Leu Leu Asn Glu Thr Lys Arg Ile Glu Gln 
    930                 935                 940                 


Val Ile Asn Thr Gln Leu Ser Phe Asp Gln Lys Gly Lys Glu Ile Lys 
945                 950                 955                 960 


Asp Lys Thr Asn Leu Glu Ile Val Lys Thr Ile Val Ala Glu Arg Lys 
                965                 970                 975     


Gln Lys Asn Tyr Thr Glu Met Arg Lys Tyr Val His Asp Arg Arg Leu 
            980                 985                 990         


Pro Glu Leu Phe Glu Tyr Ile Asp  Gly Asn Glu Leu Pro  Leu Asp Met 
        995                 1000                 1005             


Leu Leu  Asn Glu Leu Arg Ala  Tyr Asn Thr Ala Lys  Gln Val Val 
    1010                 1015                 1020             


Phe Asp  Thr Val Phe Ala Leu  Glu Lys Lys Ile Ile  Glu Thr Asp 
    1025                 1030                 1035             


Pro Glu  Gly Leu Lys Gln Leu  Asn Val Ser Lys Asp  Gly Gln Ile 
    1040                 1045                 1050             


Gln Thr  Gly Asn Ile Gln His  Lys Pro Tyr Val Gln  Trp Leu Glu 
    1055                 1060                 1065             


Asn Lys  Gly Leu Ile Thr Asp  Lys Asp Lys Gln Phe  Ile Asn Met 
    1070                 1075                 1080             


Val Arg  Asn Ser Phe Ser His  Asn Gln Phe Pro Gln  Arg Ser Thr 
    1085                 1090                 1095             


Val Glu  Leu Leu Met Pro Val  Trp Gln Asn Thr Asn  Ile Ala Leu 
    1100                 1105                 1110             


Gln Ile  Ala Arg Glu Tyr Gln  Gln Leu Ile Val Asp  Ile Ile Glu 
    1115                 1120                 1125             


Lys Ser  Leu His Pro His Lys  Gln His Gln Met Val  
    1130                 1135                 1140 


<210>  2465
<211>  1152
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2465

Met Glu Thr Asp Ser Thr Lys Glu Val Gln Ala Tyr Asn Leu Ile Glu 
1               5                   10                  15      


Thr Pro Trp Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg His Asn Met 
            20                  25                  30          


Phe Leu Leu Ile Asn His Leu Thr Glu Lys Phe Ser Tyr Leu Asn Gly 
        35                  40                  45              


Glu Lys Leu Thr Asn Asp Glu Glu Ile Cys Thr Thr Lys His Leu Leu 
    50                  55                  60                  


Val Thr Ile Phe Asp Pro Val Gln Thr Ile Tyr Glu Asp Glu Arg Phe 
65                  70                  75                  80  


Lys Val Tyr Lys Tyr Leu Val Lys Arg His Tyr Leu Pro Phe Ile Lys 
                85                  90                  95      


Ile Phe His Glu Lys Asn Gly Tyr Gln Leu Asp Ser Asn Pro Ile Val 
            100                 105                 110         


Asp Tyr Lys Gly Leu His Asn Phe Leu Leu Ser Val Phe Asn Ser Leu 
        115                 120                 125             


Asn Ser Cys Arg Asn Ser Phe Thr His Tyr Leu Ser Val Asp Asn Thr 
    130                 135                 140                 


Gly Lys Lys Ile Asp Glu Arg Lys Pro Ile Leu Asp Lys Asn Met Lys 
145                 150                 155                 160 


Ser Thr Leu Glu Gln Leu Phe Lys Leu Ala Pro Thr Phe Ser Leu Lys 
                165                 170                 175     


Arg Phe Glu Ala Ser His Glu Glu Asn Asp Phe Asp His Leu Asn Leu 
            180                 185                 190         


Tyr Glu Leu Phe His Pro Asp Ser Ser Gln Leu Thr Glu His Gly Phe 
        195                 200                 205             


Tyr Phe Phe Ile Asn Leu Phe Leu Glu Arg Ser Tyr Ala Ile Lys Phe 
    210                 215                 220                 


Leu Lys Lys Ile Arg Gly Phe Lys Asn Asp Ser Thr Pro Ser Phe Arg 
225                 230                 235                 240 


Ala Thr Ile Gln Ala Phe Thr Ala Tyr Ser Leu Arg Ile Pro Asp Val 
                245                 250                 255     


Lys Leu Asp Val Glu Asp Lys Lys Leu Ser Leu Leu Leu Glu Met Leu 
            260                 265                 270         


Asn Glu Leu Gln Arg Cys Pro Lys Glu Leu His Ser His Leu Ser Asp 
        275                 280                 285             


Glu Asp Arg Lys Ile Phe Gln Pro Ser Leu Asp Glu Lys Asp Lys Ser 
    290                 295                 300                 


Asn Ile Leu Leu Asn Ser Thr Asp Tyr Glu Asn Ile Lys Asp Glu Asp 
305                 310                 315                 320 


Ile Asp Ser Leu Ile Ser Glu Ile Thr Ser Leu Arg Arg Glu Ser Asn 
                325                 330                 335     


Arg Phe Pro Tyr Phe Ala Leu Arg Phe Ile Asp Glu Phe Asp Leu Leu 
            340                 345                 350         


Pro His Ile Arg Phe Gln Ile Thr Leu Gly Lys Leu His Val Lys Ser 
        355                 360                 365             


Tyr Glu Lys Ile Ile Thr Gly Asn Lys Lys Asn Arg Arg Ile Val Glu 
    370                 375                 380                 


Thr Ile Gln Ala Phe Gly Lys Leu Ser Asp Phe Glu His Ser Glu Asp 
385                 390                 395                 400 


Glu Ile Leu Arg Asp Leu Gln Glu Val Gly Val Ile Glu Lys Gly Cys 
                405                 410                 415     


Tyr Phe Glu Gln Tyr Ala Pro His Tyr Asn Met Glu Asn Asn Gln Leu 
            420                 425                 430         


Pro Phe Tyr Leu Phe Asp Asp Lys Lys Thr Met Lys Tyr Pro Ser Thr 
        435                 440                 445             


Pro Thr Gly Phe Ile Ser Leu Asn Asp Leu Pro Lys Ile Val Ile Leu 
    450                 455                 460                 


Ala Lys Leu Phe Pro Val Asp Ser Lys Ser Lys Lys Cys Lys Val Glu 
465                 470                 475                 480 


Asp Ile Ile Lys Asp Phe Ile Glu Ile Asp Lys Thr Cys Tyr Leu Asn 
                485                 490                 495     


Tyr Asp Glu Leu Gln Lys Ile Lys Gln Gln Leu Ser Leu Ile Pro Glu 
            500                 505                 510         


Glu Phe Thr Arg Arg Ile Ile Gln Glu Lys Ser Ile Lys Gly Arg Asn 
        515                 520                 525             


Gly Lys Pro Asp Tyr Leu Asn Leu His Lys Glu Ile Asn Leu Leu Thr 
    530                 535                 540                 


Arg Leu Asn Lys Ser Lys Glu Glu Leu Cys Leu Leu Thr Ser Asp Glu 
545                 550                 555                 560 


Leu Arg Lys Leu Thr Arg Asp Arg Lys Glu Leu Glu Tyr Ile Asn Gln 
                565                 570                 575     


Ile Arg Tyr Leu His Phe Leu Asp Lys Arg Lys Gln Glu Leu Gln Lys 
            580                 585                 590         


Tyr Leu Pro Asn Gly Leu Leu Val Asn Gln Leu Pro Glu Gln Ile Thr 
        595                 600                 605             


Arg Tyr Leu Leu Asn Ile Asn Glu Pro Asp Thr Glu Lys Thr Ile Asp 
    610                 615                 620                 


Gln Lys Ile Lys Ala Val Tyr Asp Asp Cys Asn Ile Arg Leu Lys Arg 
625                 630                 635                 640 


Ile Lys Lys Glu Thr Glu Lys Pro Gln Tyr Glu Gln Asn Ile Lys Leu 
                645                 650                 655     


Gly Glu Leu Ala Thr Phe Leu Ala Arg Asp Ile Ile Lys Met Val Val 
            660                 665                 670         


Asp Lys Asp Val Lys Gln Lys Ile Thr Ser Pro Tyr Tyr Asn Asn Leu 
        675                 680                 685             


Gln Asn Lys Ile Ala Tyr Phe Ser Ile Ser Gln Ser Glu Ile Ile Ala 
    690                 695                 700                 


Leu Cys Asn Glu Leu Gln Leu Phe Asp Asn Asn Lys Gly His Val Phe 
705                 710                 715                 720 


Leu Ser Arg Gln Leu Ile Asn Lys Ser Asn Asn Ile Ile Asp Phe Tyr 
                725                 730                 735     


Lys Asn Tyr Leu Glu Thr Lys Cys Lys Trp Ile Thr Thr His Leu Ser 
            740                 745                 750         


Lys Glu Glu Ala Ile Pro Leu Ser Leu Leu Lys Ile Lys Glu Lys Val 
        755                 760                 765             


Gly Arg Asn Asp Phe Asn His Trp Leu Ser Asn Lys Ser Thr Met Pro 
    770                 775                 780                 


Val Ser Leu Pro Asn Thr Leu Phe Asp Lys Asp Val Ser Thr Tyr Leu 
785                 790                 795                 800 


Ser Lys Glu Leu His Lys Asn Arg Met Pro Phe Asn Gln Gly Asp Lys 
                805                 810                 815     


Phe Ser Ile Leu Leu Ser Lys Phe Leu Gln Gln Asp Thr Gln Pro Phe 
            820                 825                 830         


Tyr Arg Phe Lys Arg Ile Tyr Phe Val Asn Gly Glu Pro Lys Glu Ile 
        835                 840                 845             


Asp Ile Asn Asp Leu Asp Gly Lys Thr Leu Lys Ser Arg Tyr Gly Lys 
    850                 855                 860                 


Gln Val Glu Lys Asn Glu Lys Gln Ile Arg Phe Ile Gln Thr Gln Asp 
865                 870                 875                 880 


Arg Ile Ile Lys Leu Leu Cys Glu His Ile Leu Ser Glu Tyr Asn Ser 
                885                 890                 895     


Asp Ser His His Lys Ser Leu Lys Leu Ala Ser Ile Val Pro Phe Ser 
            900                 905                 910         


Glu Glu Ser Pro Leu Asn Asn Pro Phe Gln Phe Lys Gln Arg Ile Ile 
        915                 920                 925             


Arg Lys Gly Asn Glu Thr Tyr Phe Thr Val Ile Ala Lys Asp Asn Gln 
    930                 935                 940                 


Arg Gln Leu Asp Glu Ile Ser Ala Tyr Ser Gln Leu Thr Thr Glu Asp 
945                 950                 955                 960 


Glu Lys Asn Ser Phe Lys Gly Gln Lys Gly Tyr Glu Trp Thr Val Lys 
                965                 970                 975     


Asp Phe Gly Arg Phe Lys Lys Met Thr Phe Asp Arg Arg Ile Ser Ser 
            980                 985                 990         


Leu Ser Ser Tyr Phe Glu Asn Lys  Glu Val Thr Phe Lys  Phe Leu Asp 
        995                 1000                 1005             


Tyr Gln  Leu Lys Glu Tyr Asp  Lys Tyr Arg Glu Phe  Ile Phe Glu 
    1010                 1015                 1020             


Ser Thr  Phe Gln Leu Glu Gln  His Ile Cys Asp Ile  Ala Leu Glu 
    1025                 1030                 1035             


Asp Ile  Ile Arg Ile Glu Met  Lys His Arg Thr Asn  Asp Asn Asn 
    1040                 1045                 1050             


Phe Asn  Asn Val Gln Phe Asn  Lys Tyr Thr Glu Trp  Ile Glu Asp 
    1055                 1060                 1065             


Lys Gly  Leu Leu Asn Glu Asp  Lys Ile Cys Gln Leu  Lys Lys Ile 
    1070                 1075                 1080             


Arg Asn  Gly Phe Ser His Ser  Gln Phe Pro Asp Asn  Val Ser Gly 
    1085                 1090                 1095             


Ile Pro  Lys Ile Thr Gln Leu  Asn Ile Asn Gln Phe  Glu Glu Ile 
    1100                 1105                 1110             


Tyr Gly  Val Glu Gly Arg Lys  Gly Glu Ile Glu Asn  Leu Asn Leu 
    1115                 1120                 1125             


Ser Leu  Ser Lys Leu Ile Phe  Glu Asp Tyr Lys Ser  Ile Ile Asn 
    1130                 1135                 1140             


Asn Ile  Ile Pro Ser Val Ile  Asp His 
    1145                 1150         


<210>  2466
<211>  1145
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2466

Met Thr Leu Pro Thr Asp Asn Thr Phe Ile Glu Lys Ala Asp Gln Glu 
1               5                   10                  15      


Ile Leu Gly Lys Asn Lys Leu Phe Phe Gly Ala Tyr Leu Asn Met Ala 
            20                  25                  30          


Asn His Asn Ala Tyr Leu Ile Ile Lys Asp Ile Ser Glu Arg Leu Lys 
        35                  40                  45              


Gln Glu Asp Ala Leu Asp Ile Asp Ala Pro Ser Asp Glu Asp Asn Leu 
    50                  55                  60                  


Ala Tyr Ala Asp Ile Phe Ser Lys Ile Leu Lys Lys Ala Ser Asp Lys 
65                  70                  75                  80  


Asn Pro Lys Asn Arg Pro Gln Ala Thr Ile Ile Asp Lys Val Thr Asn 
                85                  90                  95      


Leu Leu Ile His His Phe Pro Ala Phe Glu Val Phe Ala Tyr Glu His 
            100                 105                 110         


Pro Phe Glu Gln Gln Asn Ser Tyr Pro Glu Leu Leu Tyr Gln Lys Leu 
        115                 120                 125             


Thr Thr Ala Leu Lys Leu Leu Asn Asp Leu Arg Asn Glu His Ser His 
    130                 135                 140                 


Phe Tyr Tyr Lys Gly Ser Phe Asp Ile Asp Thr Val Phe Ser Ala Ala 
145                 150                 155                 160 


Gln Glu Glu Ile Thr Arg Phe Pro Tyr Leu Thr Pro Glu Asp Ile Glu 
                165                 170                 175     


Glu Leu Glu Tyr Tyr Lys Asn Asp Leu Leu Glu Pro Leu Thr Tyr Phe 
            180                 185                 190         


Lys Lys Tyr Gly Phe Val Phe Phe Ile Cys Thr Phe Leu Glu Lys Arg 
        195                 200                 205             


Tyr Ala Arg Tyr Met Leu Lys Glu Lys Gln Leu Asp Leu Ile Ala Ser 
    210                 215                 220                 


Asp Lys Glu Arg Asp Ala Thr Leu Glu Asn Phe Thr Asn Tyr Ser Cys 
225                 230                 235                 240 


Arg Leu Pro Arg Pro Lys Leu Glu Ser Ser Val Ile Glu Leu Asp Met 
                245                 250                 255     


Leu Asn Glu Leu Ser Arg Cys Pro Lys Gly Ile His Asp Val Leu Ser 
            260                 265                 270         


Ser Pro Met Glu Lys Val Leu Leu Lys Thr Asp Ala Lys Asp Asp Pro 
        275                 280                 285             


Asn Gln Val Pro Met Ile Arg His Asn Asp Arg Phe Pro Tyr Phe Ala 
    290                 295                 300                 


Leu Ser Tyr Phe Asp Lys Met Glu Arg Phe Pro Ala Met Arg Phe His 
305                 310                 315                 320 


Ile Trp Ala Gly Lys Thr Arg Leu Ala Phe Tyr Gly Lys Lys Leu Gly 
                325                 330                 335     


Lys Lys Asn Val Leu Arg Asp Ile Gln Glu Asn Val Thr Ile Tyr Ala 
            340                 345                 350         


Arg Leu Asn Asp Ile Lys Ala Asp Lys Ile Pro Asp Asn Trp Lys Asp 
        355                 360                 365             


Lys Ile Asp Val Glu Asp Ser Glu Glu Asn Lys Glu Lys Ala Lys Ile 
    370                 375                 380                 


Gln Ser Tyr Ser Pro His Tyr Asn Ile His Asn Asn Arg Ile Ala Ile 
385                 390                 395                 400 


Lys Phe Ile Asp Thr Gln Lys Asp Glu Leu Asp Thr Glu Asn Phe Ser 
                405                 410                 415     


Glu Ile Lys Ser Lys Pro Gln Asp Pro Thr Lys Asp Lys Gln Leu Lys 
            420                 425                 430         


Tyr Thr Val Thr His Ala Leu Pro Asn Ala Ile Leu Ser Thr Tyr Glu 
        435                 440                 445             


Leu Gln Asn Leu Phe Leu Tyr Asp Tyr Leu Tyr Arg Thr Tyr Lys Asp 
    450                 455                 460                 


Gln Lys Val Leu Ala Arg Pro Ala Asp Ser Phe Ile Arg Asn Tyr Ile 
465                 470                 475                 480 


Ser Ser Phe His Arg Phe Cys Lys Asp Val Lys Ser Gly Lys Ile Gln 
                485                 490                 495     


Pro Val Ser Pro His Asp Phe Glu Arg Leu Thr Glu His Thr Arg Ser 
            500                 505                 510         


Thr Thr Arg Asp Leu Gly Asn Arg Glu Glu Glu Leu Glu Ile Arg Lys 
        515                 520                 525             


Glu Ala Leu Gln Lys Lys Lys Leu Asp Asn Tyr Gly Leu Lys Val Lys 
    530                 535                 540                 


Asn Leu Pro Asp Ala Leu Arg Glu Tyr Leu Leu Gly Tyr Lys Gln Glu 
545                 550                 555                 560 


Thr Tyr Thr Glu Ile Ala Leu Asn Lys Leu Arg Gly Lys Ile Lys Gln 
                565                 570                 575     


Thr Lys Val His Tyr Lys Leu Ala Thr Lys Asp Asp Leu Phe Leu Asp 
            580                 585                 590         


Gly Lys Thr Asp Leu Lys Ser Gly Lys Ile Gly Asp Phe Leu Ala Ala 
        595                 600                 605             


Asp Ile Val Phe Leu Lys Pro Leu Asp Ala Asn Arg Thr Gly Lys Pro 
    610                 615                 620                 


Asn Asn Gln Gln Phe Asn Glu Leu Gln Lys Ala Ile Ala Arg Phe His 
625                 630                 635                 640 


Ser Gln Lys Lys Asp Val Glu Asp Phe Ile Asn Glu Glu Leu Gln Ile 
                645                 650                 655     


Lys Glu Gln Ser Leu Pro His Ala His Pro Phe Leu Tyr Lys Ile Gln 
            660                 665                 670         


Phe Glu Glu His Thr Asp Val Gln Ser Phe Tyr Ile Lys Tyr Leu Glu 
        675                 680                 685             


Leu Lys Ile Glu Trp Leu Glu Cys Thr Lys Arg Glu Ile Gln Gly Lys 
    690                 695                 700                 


Ser Asp Tyr Leu Lys Pro Trp Gln Trp Arg Glu Glu Ala Asp Lys Cys 
705                 710                 715                 720 


Lys Gln Tyr Gly Ile Asp Ile Lys Pro Glu Gly Leu Ser Asp Ala Ala 
                725                 730                 735     


Thr Glu Asn Lys Tyr Gly Tyr Phe Leu Gln Ile Asn Thr Lys Lys Gly 
            740                 745                 750         


Asn Glu Arg Asn Tyr Thr Asn Ala Thr Thr Pro Ser Lys Ala Asn Ser 
        755                 760                 765             


Lys Glu Phe Glu Ser Leu Glu Ser Lys Ser Pro Val Phe Leu Pro Arg 
    770                 775                 780                 


Gly Leu Phe Asn Asp Ala Ile Ile Asp Ala Met Met Lys Ile Asp Glu 
785                 790                 795                 800 


Phe Lys Gly Lys Ile Lys Glu Gly Asp Asn Ile Val Arg Cys Leu Asp 
                805                 810                 815     


Val Leu Ala Glu Gly Asp Arg Gln Thr Phe Tyr Asp Phe Glu Arg Ser 
            820                 825                 830         


Tyr Thr Val Gly Lys Ala Ala Pro Thr Ser Val Thr Ile His Gln Gly 
        835                 840                 845             


Ala Asn Gly Glu Tyr Ile Lys Asn Lys Leu Arg Ser Ile Lys Pro Ile 
    850                 855                 860                 


Ile Lys Lys Leu Arg Thr Gln Gln Asn Ala Lys Asp Ala Lys Tyr Lys 
865                 870                 875                 880 


Asp Lys Lys Ile Leu Gln Asn His Ile Lys Ala Leu Gln Ala Ile Ser 
                885                 890                 895     


Asp Asn Glu Arg Ser Ile Arg Phe Ile Arg Ala Asn Asp Arg Thr Leu 
            900                 905                 910         


Phe Leu Met Ile Lys His Ile Phe Ser Glu His Lys Ser Tyr Val Val 
        915                 920                 925             


Glu Gly Ser Lys Leu Thr Lys Ser Ile Asn Thr Leu Pro Trp Lys Leu 
    930                 935                 940                 


Asn Lys Val Gly Tyr Glu Ile Lys Glu Asn Asn Ile Leu Asn Glu Ile 
945                 950                 955                 960 


Leu Pro Met Asn Ile Gln Phe Asn Gln Lys Ser Ile Tyr Thr Glu Gly 
                965                 970                 975     


Glu His Gly Thr Asp Pro Leu Asn Lys Leu Ser Ile Lys His Tyr Gly 
            980                 985                 990         


Lys Phe Arg Lys Leu Leu Lys Asp  Lys Arg Leu Ser Asn  Lys Lys Lys 
        995                 1000                 1005             


Pro Gly  Leu Leu Asn Tyr Tyr  Thr Asp Gln Asn Val  Arg Trp Ser 
    1010                 1015                 1020             


Ala Ile  Asn Lys Glu Leu Glu  Tyr Tyr Asp Glu Asn  Arg Asp Arg 
    1025                 1030                 1035             


Leu Leu  Asp Val Ile Tyr Lys  Phe Glu Lys Ala Val  Trp Glu Asn 
    1040                 1045                 1050             


Glu Glu  Cys Arg Glu Glu Leu  Lys Glu Asn Ile Arg  Leu Gly Tyr 
    1055                 1060                 1065             


Ile Asn  His Ala Thr Gln Leu  Lys Ala Val Gly Lys  Ile Val Arg 
    1070                 1075                 1080             


Gly Phe  Thr Ala Ser Lys Gln  Asp Gln Leu Ala Leu  Leu Arg Asn 
    1085                 1090                 1095             


Lys Phe  Leu His Asn Gln Ile  Pro Tyr Thr Glu Asn  Leu Lys Thr 
    1100                 1105                 1110             


Gly Trp  Val Asp Asn Asn Pro  Glu Tyr Pro Leu Ile  Thr Gln Ala 
    1115                 1120                 1125             


Leu Leu  Glu Leu Ala Ile Ile  Glu Tyr Gln Asn Ile  Thr Lys Asn 
    1130                 1135                 1140             


Ile Ile  
    1145 


<210>  2467
<211>  1145
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2467

Met Thr Leu Pro Thr Asp Asn Thr Phe Ile Glu Arg Pro Asp Glu Lys 
1               5                   10                  15      


Ile Leu Tyr Gln Asn Lys Leu Phe Phe Gly Ala Tyr Leu Asn Met Ala 
            20                  25                  30          


Gln His Asn Ala Tyr Leu Ile Ile Lys Asp Ile Ser Glu Gln Phe Gly 
        35                  40                  45              


Leu Asp Ile Ser Thr Leu Gln Glu Asn Gln Leu Glu Ser Ala Asp Leu 
    50                  55                  60                  


Ile Lys Lys Leu Lys Gly Lys Gly Gly Arg Pro Lys Asn Ser Val Gln 
65                  70                  75                  80  


Met Thr Asn Ala Leu Val Arg Arg Leu Pro Phe Leu Glu Ala Met Lys 
                85                  90                  95      


Ala Pro Glu Glu Ser Thr Tyr Lys Ala Gly Thr Glu Lys Glu Lys Glu 
            100                 105                 110         


Val Ile His Ala Lys Glu Ile Gln Ser Gly Glu Val Gly Lys Ile Leu 
        115                 120                 125             


Thr Thr Ala Phe Glu Phe Met Gly Gln Leu Arg Asn Phe Tyr Ser His 
    130                 135                 140                 


Tyr His His Glu Asp Val Asp Phe Lys Asp Phe Ser Val Ile Glu Ile 
145                 150                 155                 160 


Ile Phe Asp Asn Ala Ile Lys Arg Ala Ile Lys Arg Ile Pro Asp Val 
                165                 170                 175     


Asn Glu Glu Asn Thr Asn His Leu Leu Asn Ala Pro Thr Tyr Ala Met 
            180                 185                 190         


Tyr Lys Asp Gly Lys Leu Thr Asn Leu Gly Leu Thr Phe Phe Ile Cys 
        195                 200                 205             


Leu Phe Leu Glu Arg Lys Tyr Ala Tyr Leu Phe Leu Met Gln Leu Glu 
    210                 215                 220                 


His Phe Lys Gly Gln Asn Asp Phe Val Tyr Ser Asn Arg Arg Cys Phe 
225                 230                 235                 240 


Thr Asp Leu Ser Cys Asn Leu Pro Lys Pro Lys Leu Gly Ser Ser Glu 
                245                 250                 255     


Ile Glu Met Asp Ile Leu Gly Glu Leu Ala Arg Cys Pro Lys Glu Leu 
            260                 265                 270         


Phe Tyr Arg Leu Ser Glu Glu Asp Lys Asn Lys Phe Phe Ala Glu Gln 
        275                 280                 285             


Lys Glu Thr Glu Asp Glu Ile Pro Pro Pro Ile Met Lys Arg Lys Asp 
    290                 295                 300                 


Asp Arg Phe Ala Ser Phe Ala Leu Arg Tyr Leu Glu Glu Lys Arg Leu 
305                 310                 315                 320 


Asn Lys Met Arg Phe Gln Ile His Leu Gly Lys Val Arg Arg Ile Gly 
                325                 330                 335     


Glu Lys His Gln Tyr Asp Lys Thr Ile Ala Gly Val Glu Ala Glu Arg 
            340                 345                 350         


Val Ile Met Glu Asn Leu Arg Thr Phe Ala Lys Leu Ser Glu Thr Asn 
        355                 360                 365             


Thr Glu Lys Thr Pro Glu His Trp Arg Val Phe Asn Arg Asp Thr Asn 
    370                 375                 380                 


Lys Lys Asp Leu Ile Arg Thr Glu Ile Glu Gln Phe Arg Pro Arg His 
385                 390                 395                 400 


Gln Ile Thr Gly Asn Arg Ile Ala Leu Lys Phe Leu Thr Glu Glu Arg 
                405                 410                 415     


Asn Ser Val Phe Pro Asp Leu Lys Phe Asp Asn Asn Gln Thr Lys Leu 
            420                 425                 430         


Gln Ala Leu Asp Thr Pro Asp Ala Ile Leu Ser Thr Tyr Glu Leu Gln 
        435                 440                 445             


Asn Leu Val Met Tyr Asp Gln Leu His Lys Glu Gly Ala Ile Glu Lys 
    450                 455                 460                 


Asp Val Glu Thr Phe Ile Ala Asp Tyr Ile Leu Asn Phe Arg Lys Phe 
465                 470                 475                 480 


Cys Glu Ala Val Asp Lys Gly Glu Val Thr Pro Val Ala Asp Ala Asp 
                485                 490                 495     


Phe Ile Lys Val Val Lys Ala Ser Gly Lys Ser Lys Pro Glu Tyr Ser 
            500                 505                 510         


Glu Ala Gln Leu Val Glu Leu Lys Asn Arg Gln Gln Ser Leu Lys Gly 
        515                 520                 525             


Ile Leu Thr Asn Tyr Gly Leu Gln Ile Gln Gln Leu Pro Asp Asn Leu 
    530                 535                 540                 


Arg Glu Tyr Leu Leu Gly Tyr Ala Pro Val Asn Tyr Lys Arg Glu Ala 
545                 550                 555                 560 


Leu Arg Ile Leu Glu Thr Lys Phe Ser Glu Thr Leu Lys Leu Arg Thr 
                565                 570                 575     


Asp Ser Gln Lys Gly Phe Gly Pro Lys Val Gly Glu Met Ala Thr Phe 
            580                 585                 590         


Leu Ala Arg Asp Ile Asn His Leu Lys Pro Pro Arg Glu Trp Lys Asp 
        595                 600                 605             


Ser Lys Val Arg Leu Asn Asp Glu Gln Tyr Asp Asn Leu Gln Ala Ala 
    610                 615                 620                 


Ile Ser Gln Phe Ser Gly Gln Ile Pro Gln Ile Glu Ala Leu Phe Asp 
625                 630                 635                 640 


Glu Leu Glu Leu Thr Lys Ser Tyr Ser Arg Ser Arg Ala Glu Asn Glu 
                645                 650                 655     


Ala Leu Gln Ala Leu Met His Pro Phe Leu Phe Arg Ile Lys Leu Gln 
            660                 665                 670         


Asp Ser Ala Asn Gln Gly Gly Ile His Ile Phe Tyr Gln Arg Tyr Leu 
        675                 680                 685             


Asn Lys Lys Ala Asp Trp Leu Gln Gly Leu Met Leu Leu Leu Lys Gln 
    690                 695                 700                 


Glu Pro Tyr Gly Asp Phe Gly Pro Phe Asn Asn Phe Pro Glu Gly Tyr 
705                 710                 715                 720 


Gln Asn Ile Ser Leu Pro Glu Phe Thr Lys Lys Phe Asp Tyr Val Leu 
                725                 730                 735     


Arg Ile Asp Lys Lys Leu Asn Arg Lys Lys Gln Tyr Leu Phe Ser Asp 
            740                 745                 750         


Lys Glu Lys Thr Gln Lys Ser Ala Ile Phe Leu Pro Arg Gly Leu Phe 
        755                 760                 765             


Asn Ala Pro Ile Met Glu Ala Leu Phe Phe Lys Lys Asn Ile Glu Val 
    770                 775                 780                 


Glu Pro Asp Asp Ser Leu Val Met Ala Met Ser Lys Tyr Lys Pro Asp 
785                 790                 795                 800 


Ser Gln Ser Phe Tyr Asn Phe Glu Arg Ile Tyr Thr Leu Lys Gly Arg 
                805                 810                 815     


Asp Glu Ala Pro Asp Thr Leu Tyr Thr Gly Asp Ala Asn Gln Ile Gly 
            820                 825                 830         


Ala Gln Met Gln Val Leu Lys Lys Glu Ile Glu Gln Met Gln Ser Lys 
        835                 840                 845             


Arg Lys Ala Met Ser Leu Pro Ala Asp Trp Trp Glu Thr Tyr Ser Gln 
    850                 855                 860                 


Lys Asn Lys Gly Lys Lys Lys Lys Glu Glu Leu Thr Ser Ile Gln Lys 
865                 870                 875                 880 


Thr Ala Gln Asn Leu Glu Tyr Gln Ile Asn Asp Leu Lys Lys Phe Arg 
                885                 890                 895     


Arg Ser Val Met Thr Asn Glu Gln Thr Leu Arg Tyr Arg Gln Thr Asn 
            900                 905                 910         


Asp Arg Val Leu Trp Leu Ile Val Lys Asn Tyr Phe Glu Asp Ile Asp 
        915                 920                 925             


Ser His Phe Asn Ile Asp Ile Ser Glu Trp Glu Leu His Asn Val Gly 
    930                 935                 940                 


Phe Glu Ile Lys Glu Lys Asn Val Leu Asn Thr Lys Ile Asp Leu Ser 
945                 950                 955                 960 


Phe Pro Leu Tyr Gly Tyr Thr Ile His Thr Lys Gln Ser Glu Gly Glu 
                965                 970                 975     


Asn Val Pro Val His Glu Ser Asp His Leu Thr Ile Lys Arg Tyr Gly 
            980                 985                 990         


Glu Phe Arg Tyr Val Leu Lys Asp  Arg Arg Leu Trp Ser  Glu Lys Val 
        995                 1000                 1005             


His Gln  Asp Gly Asn Ile Glu  Lys Thr Gly Ile Leu  Arg Tyr Tyr 
    1010                 1015                 1020             


Ser Pro  Asp Thr Pro Ile Ala  Trp Ser Ile Leu Lys  Arg Glu Leu 
    1025                 1030                 1035             


Asp Thr  Tyr Asp Gly Glu Asp  Arg His Lys Leu Met  Asn His Ile 
    1040                 1045                 1050             


His Ala  Phe Glu Tyr Asp Met  Tyr Thr Met His Glu  Glu Lys Met 
    1055                 1060                 1065             


Glu Arg  Glu Ser Gly Ala Lys  Ile Ile Asn His Leu  Lys Gln Leu 
    1070                 1075                 1080             


Glu Ala  Val His Asn Tyr Ile  Ala Gln Ile Asp Lys  Pro Asn His 
    1085                 1090                 1095             


Leu Met  Ile Asn Glu Leu Arg  Ser Lys Phe Met His  Asn Gln Ile 
    1100                 1105                 1110             


Pro Phe  Asn Ala Trp Leu Glu  Asn Glu Leu Lys Asn  Thr Pro Lys 
    1115                 1120                 1125             


Gly Ser  Lys Val Lys Gln Leu  Leu Asp Ile Ala Thr  Lys Ala Tyr 
    1130                 1135                 1140             


His Asn  
    1145 


<210>  2468
<211>  1124
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2468

Met Ser Val Ala Thr Gln Glu His Ile Asn Ser Leu Lys Phe Ile Glu 
1               5                   10                  15      


Thr Ala Glu Arg Asn Lys Phe Tyr Tyr Gly Met Tyr Leu Ser Val Ala 
            20                  25                  30          


Gln Arg Asn Ala Tyr Leu Ser Leu Lys Ser Ile Tyr Glu Lys Leu Glu 
        35                  40                  45              


Ile Lys Glu Glu Lys Arg Gln Ile Ser Glu Asp Asn Pro His Lys Ala 
    50                  55                  60                  


Asp Ile Phe Cys Glu Leu Ile Pro Pro Asp Glu Asn Thr Ser Asn Cys 
65                  70                  75                  80  


Asp Ala His Pro Tyr Val Gln Leu Arg Pro Ser Glu Ile Glu Ser Arg 
                85                  90                  95      


Lys Arg Leu Leu Ala Lys His Phe Pro Ala Phe Arg Lys Leu Ser Glu 
            100                 105                 110         


Thr Ile Asn Glu Lys Gly Lys Val Thr Gly Phe Asp Val Val Arg Leu 
        115                 120                 125             


Ala Lys Leu Leu Lys Cys Ser Leu Glu Tyr Leu Asn Lys Leu Arg Asn 
    130                 135                 140                 


Tyr Phe Ser His Tyr Tyr His Lys Pro Ile Ser Gly Asp Thr Ile Pro 
145                 150                 155                 160 


Asp Ile Tyr Leu Pro Glu Leu Leu Glu Ala Ala Val Glu Lys Val Gln 
                165                 170                 175     


Lys Arg Phe Pro Asp Ile Asn Thr Glu His Gly Glu Tyr Leu Lys Thr 
            180                 185                 190         


Leu Pro Leu Thr Val Asp Asn Gln Tyr Asn Tyr Asn Gly Gly Ile Leu 
        195                 200                 205             


Phe Met Cys Met Phe Leu Asp Arg Arg Asn Ala Phe Ala Phe Leu Lys 
    210                 215                 220                 


Thr Thr Tyr Met Arg Gly Phe Lys Asp Ser Arg Thr Pro Asp Met Arg 
225                 230                 235                 240 


Val Lys Pro Glu Ala Phe Ile Tyr Phe Cys Ala Arg Pro Pro Gln Pro 
                245                 250                 255     


Lys Leu Gly Ser Ser Asp Leu Pro Leu Asp Met Leu Thr Glu Ile Ser 
            260                 265                 270         


Arg Cys Pro Asn Glu Ile Phe Gln Leu Leu Ser Thr Asn Asp Lys Lys 
        275                 280                 285             


Lys Phe Glu Ala Asp Ile Asp Asp Asp Ala Lys Pro Thr Glu Leu Asp 
    290                 295                 300                 


Glu Phe Leu Lys Asp Glu Leu Pro Pro Arg Thr Ala Asn Met Lys Arg 
305                 310                 315                 320 


Lys Ala Glu Asn Ser His Phe Pro Arg Tyr Ala Met Arg Tyr Phe Asp 
                325                 330                 335     


Glu Gln Lys Lys Phe Gly Arg Leu Arg Phe Gln Leu Leu Cys Ala Lys 
            340                 345                 350         


Phe Asn Cys Ala Asp Tyr Lys Ser Thr Ile Leu Glu Gln Glu Arg Asn 
        355                 360                 365             


Arg Lys Ile Glu Asp Thr Leu Thr Val Phe Thr Arg Leu Asn Glu Ile 
    370                 375                 380                 


Thr Glu Asp Glu Ile Glu Ser Ser Trp Lys Thr Glu Asp Thr Asp Asn 
385                 390                 395                 400 


Glu His Ile Gly Ile Lys Gln Tyr Ser Pro Lys Tyr Asn Ile Val Gly 
                405                 410                 415     


Asn Arg Ile Ala Ile Lys Ile Leu Pro Glu Glu Ile Thr Asn Asp Ile 
            420                 425                 430         


Glu Thr Thr Ser Ile Val His Pro Lys Ser Thr His Thr Asp Lys Pro 
        435                 440                 445             


Arg His Lys Val Asn His Pro Leu Pro Thr Ala Ile Leu Ser Val His 
    450                 455                 460                 


Glu Leu Gln Asn Leu Phe Leu Phe Arg His Leu His Asn Glu Glu Asn 
465                 470                 475                 480 


Ala Thr Glu Asn Phe Ile Glu Thr Tyr Ile Lys Arg Phe Arg Asp Phe 
                485                 490                 495     


Cys Gln Glu Val Asn Glu Gly Asp Phe Leu Pro Val Ser Asn Phe Leu 
            500                 505                 510         


Asp Cys Leu Val Ser Lys Lys Ser Lys Asp Gln Asp Lys Ala Ala Arg 
        515                 520                 525             


Lys Thr Ala Leu Gln Ala Lys Leu Lys Ala Lys Lys Leu His Ile Asn 
    530                 535                 540                 


Asp Leu Pro Asp Gln Met Arg Asp Tyr Leu Met Gly Tyr Thr Gln Asp 
545                 550                 555                 560 


Asn His Ser Asn Gln Leu Lys Ala Lys Leu Lys Ala Lys Ile Ile Glu 
                565                 570                 575     


Thr Glu Ala Leu Leu Ser Asn Ala Lys Arg Gly Lys Asp Ala Gln Gly 
            580                 585                 590         


Arg Asp Leu Lys Asp Gly Arg Met Ala Thr Tyr Ile Ala Arg Asp Leu 
        595                 600                 605             


Ile Phe Phe Lys Lys Lys Asn Asn Ser Gly Gly Lys Ala Asn Asn Glu 
    610                 615                 620                 


Gln Tyr Asn Glu Leu Gln Lys Ala Ile Ala Leu Phe Pro Ser His Lys 
625                 630                 635                 640 


Gly Lys Leu Gly Gln Tyr Phe Lys Asp Leu Asn Leu Leu Asp Ser Ser 
                645                 650                 655     


Thr Gly His Gln Phe Leu His Glu Ile Pro Trp Ser Tyr Cys Val Asp 
            660                 665                 670         


Thr Ala Asp Phe Tyr Thr Asp Tyr Leu Glu Gly Lys Lys Thr Trp Leu 
        675                 680                 685             


Glu Ser Cys Arg Arg Lys Leu Ser Ser Lys Gln Ala Asp Ile Gln Gln 
    690                 695                 700                 


Phe Phe Lys Leu Lys Lys Thr Asp Ser Lys Asn Leu Asn Tyr Arg Phe 
705                 710                 715                 720 


Thr Val Asn Gln Asn Ser Met Thr Glu Glu Pro Ala Pro Ile Tyr Leu 
                725                 730                 735     


Pro Arg Gly Leu Phe Asn Gly Ala Ile Arg Lys Ala Met Lys Asn Gln 
            740                 745                 750         


Gly Phe Asp Val Asn Lys Glu Thr Ser Ile Thr Lys Cys Phe Glu Leu 
        755                 760                 765             


Ile Ser Lys Gln Asp Thr Gln Thr Phe Tyr Thr His Pro Arg Thr Tyr 
    770                 775                 780                 


Tyr Asp Gly Ile Val Ile Thr Gly Lys Asp Asp Met Lys Ala Val Lys 
785                 790                 795                 800 


Ala Asp Ile Gln Gln Lys Thr Glu Gln Thr Lys Thr Lys Leu Lys Arg 
                805                 810                 815     


Ile Lys Asn Lys Lys Ser Glu Asp Ala Lys Lys Leu Gln Tyr Lys Ile 
            820                 825                 830         


Asn Asp Leu Asn Lys Leu Pro Lys Glu Ile Tyr Arg Asn Glu Leu Lys 
        835                 840                 845             


Ile Arg Phe Ile Gln Ala Asn Asp Arg Ala Ala Phe Met Met Ile Gln 
    850                 855                 860                 


Glu Met Leu Glu Ala Lys Ile Lys Ala Asp Gln Val Gln Leu Arg Ala 
865                 870                 875                 880 


Pro Asp Ser Asp Thr Ser Lys Trp Gln Leu Arg Lys Val Gly Phe Asp 
                885                 890                 895     


Val Lys Asp Asn Ile Leu Asp Gln Lys His Leu Met Gln His Thr Tyr 
            900                 905                 910         


Lys Leu Glu Tyr Lys Asp Lys Asn Asn Ser Asn Asn Asp Glu Tyr Phe 
        915                 920                 925             


Gly Ser Arg Thr Ile Gln Ala Leu Leu Pro Phe Lys Gln Tyr Gly Lys 
    930                 935                 940                 


Phe Arg Arg Phe Leu Lys Asp Lys Arg Leu Trp Ser Thr Arg Thr Lys 
945                 950                 955                 960 


Asp Gly Leu Arg Leu Pro Gln Gly Leu Leu Ser Tyr Tyr Ser Glu Gly 
                965                 970                 975     


Asp Val Ile Glu Leu Glu Thr Ile Arg Arg Glu Phe Val Asn Phe Asp 
            980                 985                 990         


Thr Lys Cys Tyr Glu Glu Thr Leu  Leu His Ile Tyr Asp  Phe Glu Ser 
        995                 1000                 1005             


Ile Leu  His Gln Glu Phe Gln  Thr Glu Phe Asn Glu  Lys Ile Arg 
    1010                 1015                 1020             


Asn Lys  Lys Ser Leu Arg His  Gly Asp Gln Leu Ala  Leu Val Gln 
    1025                 1030                 1035             


Thr Lys  Ile Leu Asn Asn Thr  Ser Val Leu Thr Asn  Pro Asp Lys 
    1040                 1045                 1050             


Asp Asp  Thr Ala Ile Met Arg  Asn Lys Ile Phe His  His Gln Ile 
    1055                 1060                 1065             


Pro Asn  Asn Asp Trp Leu Thr  Gln Lys Val Ile Val  Tyr Lys Gly 
    1070                 1075                 1080             


Leu Glu  Ala Asn Arg Lys Lys  Gln Asp Glu Asp Asn  Pro Phe Ile 
    1085                 1090                 1095             


Thr Gln  Gln Ile Phe Val Gly  Ile Gln Thr Val Tyr  Lys Asp Leu 
    1100                 1105                 1110             


Thr Gln  Arg Met Lys Ile Arg  Met Asn Gln Pro 
    1115                 1120                 


<210>  2469
<211>  1313
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2469

Met Gly Asn Ser Gly Tyr Lys Gly Thr Ser Asn Pro Ser Lys Lys Ser 
1               5                   10                  15      


Asp Lys Lys Gly Asn Val Ile Asn Lys Ile Arg Arg Leu Gln Glu Lys 
            20                  25                  30          


Asp Phe Thr Ile Asp Leu Ser Gly Arg His Val Phe Gly Ala Tyr Phe 
        35                  40                  45              


Asn Met Ala Arg Thr Asn Phe Val Lys Thr Ile Asn Tyr Ile Leu Pro 
    50                  55                  60                  


Ile Ala Gly Val Arg Gly Asn Tyr Ala Glu Asn Gln Val Asn Lys Met 
65                  70                  75                  80  


Leu Asp Ala Leu Phe Leu Ile His Ala Asn Arg Glu Lys Glu Leu Thr 
                85                  90                  95      


Gln Glu Gln Leu Gln Trp Lys Lys Lys Leu Ile Leu Asn Pro Glu Gln 
            100                 105                 110         


Gln Thr Arg Leu Gln Arg Leu Leu Phe Lys His Phe Pro Ile Leu Arg 
        115                 120                 125             


Pro Met Met Ala Asp Val Ala Glu His Lys Ala Tyr Leu Asn Lys Lys 
    130                 135                 140                 


Lys Ser Asn Val Thr Thr Glu Asp Glu Ala Phe Glu Gln Leu Arg Gly 
145                 150                 155                 160 


Ile Ser Leu Ala Asp Cys Leu Glu Asn Leu Ser Leu Ile Ala Lys Thr 
                165                 170                 175     


Leu Thr Glu Cys Arg Asn Thr Tyr Thr His Arg Lys Pro Tyr Asn Thr 
            180                 185                 190         


Pro Leu Gln Trp Ala Glu Gln Tyr Arg His Gln Asp Gln Leu Ala Cys 
        195                 200                 205             


Lys Leu Asp Lys Val Ile Val Ala Ser Arg Arg Val Leu Lys Asp Arg 
    210                 215                 220                 


Asp Gly Leu Thr Val Asn Glu Leu Glu Phe Leu Thr Gly Ile Asp His 
225                 230                 235                 240 


Met Lys Gln Val Val Thr Leu Asp Glu Asn Gly Gln Ala Ile Ile Lys 
                245                 250                 255     


Asp Gly Lys Lys Leu Lys Thr Phe Lys Glu Tyr Glu Asp Phe Tyr Phe 
            260                 265                 270         


Lys Ile Lys Gly Lys Arg Glu Val Lys Gly Leu Glu Met Ala Asn Asn 
        275                 280                 285             


Ser Ser Val Asp Thr Met Leu Pro Ala Phe Ser Asp Phe Gly Leu Leu 
    290                 295                 300                 


Tyr Phe Cys Val Gln Phe Leu Ser Lys Pro Tyr Ala Lys Leu Phe Met 
305                 310                 315                 320 


Asp Glu Thr His Leu Phe Glu Phe Ser Pro Phe Lys Asp Asp Glu Asn 
                325                 330                 335     


Ile Val Met Gln Glu Met Met Leu Ile Tyr Arg Ile Arg Pro Pro Lys 
            340                 345                 350         


Leu His Arg Ile Asp Ser Arg Asp Ser Lys Ser Thr Leu Thr Met Asp 
        355                 360                 365             


Ile Phe Ala Glu Leu Gly Arg Cys Pro Ile Glu Leu Tyr Glu Ile Leu 
    370                 375                 380                 


Asn Lys Thr Gly Gln Ser Phe Phe His Asp Val Val Lys His Pro Asn 
385                 390                 395                 400 


Ser His Thr Pro Asp Val Ser Lys Arg Ile Arg Tyr Thr Asp Arg Phe 
                405                 410                 415     


Pro Gln Leu Val Leu Arg Tyr Ile Asp Glu Asn Glu Val Phe Lys Arg 
            420                 425                 430         


Ile Arg Phe Gln Leu Gln Leu Gly Ala Phe Arg Tyr Lys Phe Tyr Asp 
        435                 440                 445             


Lys Glu Cys Ile Asp Gly Arg Pro Arg Val Arg Arg Ile Gln Lys Asp 
    450                 455                 460                 


Ile Asn Gly Tyr Gly Arg Leu Gln Glu Val Glu Ala Lys Arg Tyr Asp 
465                 470                 475                 480 


Lys Trp Gly Asp Leu Ile Gln Lys Arg Glu Glu Arg Asn Val Lys Leu 
                485                 490                 495     


Glu His Glu Glu Leu Tyr Val Asp Leu Asp Gln Phe Val Gln Asp Thr 
            500                 505                 510         


Ala Asp Ser Thr Pro Tyr Ile Thr Asp Arg Arg Pro Thr Tyr Asn Ile 
        515                 520                 525             


His Ala Asn Arg Ile Gly Leu Tyr Trp Glu Asp Ser Gln Asn Pro Asn 
    530                 535                 540                 


Asp Phe Thr Leu Phe Asp Ala Asn Leu Met Tyr Leu Pro Gln Leu Thr 
545                 550                 555                 560 


Val Thr Asp Asp Lys Lys Ala Pro Ile Lys Met Pro Ala Pro Arg Ser 
                565                 570                 575     


Thr Leu Ser Val Tyr Asp Leu Pro Ala Met Leu Phe Tyr Glu Tyr Leu 
            580                 585                 590         


Arg Thr Gln Gln Lys Gly Asn Leu Thr Ser Ala Glu Gln Ile Ile Met 
        595                 600                 605             


Asp Tyr Glu Ala Asp Tyr His Arg Phe Phe Thr Ala Val Ala Asp Gly 
    610                 615                 620                 


Thr Ile Lys Pro Phe Gly Gln Ser Lys Glu Phe Arg Glu Phe Leu Ala 
625                 630                 635                 640 


Thr Asn Tyr Pro Lys Leu Lys Met Ala Asp Ile Pro Glu Lys Leu Arg 
                645                 650                 655     


Leu Tyr Leu Ser Ser Lys Ser Leu Thr Tyr Gly Asn Lys Pro Glu Thr 
            660                 665                 670         


Val Arg Gln Arg Leu Ile Arg Ile Thr Leu Gly His Leu Lys Glu Arg 
        675                 680                 685             


Glu Glu Arg Val Cys Arg Arg Ile His Asn Tyr Lys Glu Asp Arg Lys 
    690                 695                 700                 


Lys Ile Gly Asp Lys Thr Asn Lys Ile Gly Lys Arg Asp Phe Val Asp 
705                 710                 715                 720 


Val Arg His Gly Ala Leu Ala Arg Tyr Leu Ala Gln Ser Met Met Glu 
                725                 730                 735     


Trp Gln Pro Thr Gln Asp Gly Leu Gly His Asp Lys Leu Thr Gly Leu 
            740                 745                 750         


Asn Tyr Asn Val Leu Thr Ala Tyr Leu Ala Thr Tyr Gly Thr Ser Gln 
        755                 760                 765             


Pro Val Glu Glu Gly Phe Thr Pro His Thr Leu Ala Gln Val Leu Thr 
    770                 775                 780                 


Glu Ala His Leu Ile Gly Gly His Asn Pro His Pro Phe Ile Asp Lys 
785                 790                 795                 800 


Val Leu Ala Lys Arg Asn Thr Asn Ile Glu Asp Phe Tyr Leu Asn Tyr 
                805                 810                 815     


Leu Asn Glu Glu Leu Lys His Leu Arg Ser Arg Arg Gln Ser Leu Glu 
            820                 825                 830         


Ser Asn Pro Thr Asp Lys Ala Phe Ala Ala Leu Pro Phe Val His His 
        835                 840                 845             


Thr Arg Asn Arg Tyr His Glu His Thr Glu Glu Glu Met Lys Lys Leu 
    850                 855                 860                 


Ala Ala Glu Tyr Asp Thr Ile Gln Leu Pro Asp Gly Leu Phe Thr Lys 
865                 870                 875                 880 


Tyr Ile Tyr Asp Leu Leu Lys Lys Tyr Tyr Thr Asp Asn Val Glu Leu 
                885                 890                 895     


Gln Gln Lys Leu Asn Glu Ile Ala Pro Asp Lys Leu Asn Pro Leu Asn 
            900                 905                 910         


Asn Ala Ala Tyr Leu Ile Thr Leu Phe Tyr Gln Thr Glu Leu Lys Asp 
        915                 920                 925             


Asp Ala Gln Pro Phe Tyr His Ser Asp Arg Thr Tyr Thr Val Val Asn 
    930                 935                 940                 


Glu Glu Gly Lys Lys Ile Asn Tyr Ser Phe Lys Arg Ala Tyr Glu Leu 
945                 950                 955                 960 


Phe Ser Ile Leu Arg Asn Lys Lys Lys Glu Thr Phe Pro Tyr Glu Leu 
                965                 970                 975     


Ile Pro Phe Tyr Gln Thr Ser Glu Gln Ile Gln Glu Arg Ile Ser Glu 
            980                 985                 990         


Lys Leu Leu Asp Glu Glu Gly Thr  Pro Ile Pro Gln Gln  Gly Lys Arg 
        995                 1000                 1005             


Gly Lys  Ala Ala Thr Asp Thr  Gln Gly Asn Ile Ile  Trp Glu Arg 
    1010                 1015                 1020             


Lys Leu  Lys Tyr Asp Ile Asp  Glu Tyr Val Asp Ser  Arg Thr Asp 
    1025                 1030                 1035             


Lys Asp  Leu Met Ile Ala Gln  Asn Gln Ser Trp Ser  Lys Lys Asn 
    1040                 1045                 1050             


Glu Glu  Arg Gln Glu Lys Arg  Glu Ala Leu Ser Lys  Arg Leu Asn 
    1055                 1060                 1065             


His Gln  Ile Lys Asp Val Lys  Asn Asn Glu Arg Met  Leu Arg Arg 
    1070                 1075                 1080             


Tyr Lys  Thr Gln Asp Met Val  Leu Phe Leu Leu Ala  Thr Glu Met 
    1085                 1090                 1095             


Phe Asp  Ser Ile Leu Thr Glu  Gln Asn Arg Glu Val  Asn Trp Asp 
    1100                 1105                 1110             


Asn Leu  Arg Leu Asp Arg Val  Cys Glu Arg Ser Phe  Leu Ser Gln 
    1115                 1120                 1125             


Thr Leu  Thr Phe Gln Val Pro  Val Thr Ile Ser Gly  Lys Thr Val 
    1130                 1135                 1140             


Tyr Val  Glu Gln Glu Asn Met  Ser Leu Lys Asn Tyr  Gly Glu Phe 
    1145                 1150                 1155             


Tyr Arg  Phe Leu Thr Asp Asp  Arg Leu Asp Ser Leu  Leu Ala Asn 
    1160                 1165                 1170             


Ile Val  Asp Thr Leu Lys Pro  Asn Lys Asp Gly Lys  Leu Val Ile 
    1175                 1180                 1185             


Arg His  Thr Asp Leu Met Ser  Glu Leu Ala Ala Tyr  Asp Gln Gln 
    1190                 1195                 1200             


Arg Ser  Thr Val Phe Arg Met  Ile Gln Lys Ile Glu  Lys Leu Ile 
    1205                 1210                 1215             


Ile Asp  Lys His Gly Ile Leu  Arg Lys Pro Asp Thr  Pro Asp Phe 
    1220                 1225                 1230             


Trp Val  Lys Glu Gly Leu Pro  Lys Arg Asn Asn Phe  Ala Ser Leu 
    1235                 1240                 1245             


Leu Glu  Leu Val Asn Arg Leu  Gly Asp Val Glu Leu  Asn Glu Glu 
    1250                 1255                 1260             


Glu Arg  Lys Leu Leu Val Ala  Ile Arg Asn Ala Phe  Ser His Asn 
    1265                 1270                 1275             


Ser Tyr  Asn Ile Asp Leu Ser  Gln Ile Gln Gly Ile  Lys Lys Leu 
    1280                 1285                 1290             


Pro Glu  Val Ala Lys Ser Ile  Leu Leu His Leu Glu  Lys Ile Leu 
    1295                 1300                 1305             


Gly Asp  Asn Lys Lys 
    1310             


<210>  2470
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2470

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2471
<211>  1147
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2471

Met Glu Ile Ala Thr Gln Gln Ser Glu Thr Gln Lys Lys Lys Arg Ser 
1               5                   10                  15      


Leu Asp Gln Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg 
            20                  25                  30          


His Asn Val Phe Leu Ile Val Asn His Leu Thr Asp Thr Phe Lys Glu 
        35                  40                  45              


Leu Asn Phe Lys Lys Leu Ala Asn Glu Glu Asp Ile Trp Lys Val Asp 
    50                  55                  60                  


Asn Ser Ser Asn Ile Leu Leu Asn Val Phe Asp Val Thr Gln Ser Lys 
65                  70                  75                  80  


Tyr Glu Asp Phe Arg Pro Arg Ile Phe His Tyr Leu Ile Lys Arg His 
                85                  90                  95      


His Leu Pro Leu Val Lys Ile Phe Asn Thr Glu Tyr Leu Gly Glu Asn 
            100                 105                 110         


Ile Leu Gln Asp Lys Ser Ile Asp Tyr Glu Arg Leu His Gln Phe Leu 
        115                 120                 125             


Cys Leu Ser Phe Lys Glu Leu Thr Glu Phe Arg Asn Ser Tyr Ser His 
    130                 135                 140                 


Ser Ile Ala Ile Asp Glu Asn Gly Asn Lys Val Gly Arg Lys Thr Thr 
145                 150                 155                 160 


Leu Ala Asn Asp Leu Val Pro Glu Val Asn Leu Leu Phe Lys Tyr Ala 
                165                 170                 175     


Pro Lys Tyr Ser Phe Leu Arg Asn His Gln Thr Leu Asn Glu Gly Asp 
            180                 185                 190         


Phe Gln His Leu Asp Asn Tyr Gln Leu Phe Ile Ala Asp Asn Gln Leu 
        195                 200                 205             


Thr His Gln Gly Arg Phe Phe Phe Ile Asn Leu Phe Leu Glu Arg Ser 
    210                 215                 220                 


Tyr Gly Ile Lys Phe Leu Lys Arg Phe Arg Gly Phe Lys Asn Glu Asn 
225                 230                 235                 240 


Thr Pro Pro Phe Lys Ala Thr Ile Gln Ser Phe Thr Thr Tyr Cys Leu 
                245                 250                 255     


Lys Val Pro Asp Ile Arg Leu Gly Asn Glu Asn Pro Lys Gln Ser Leu 
            260                 265                 270         


Leu Leu Asp Met Leu Thr Glu Leu Asn Lys Cys Pro Lys Glu Leu Phe 
        275                 280                 285             


Asn His Leu Thr Glu Asp Asp Lys Lys Glu Phe Glu Pro Asn Leu Asp 
    290                 295                 300                 


Glu Thr Ser Ser Thr Asn Val Leu Leu Asn Ser Thr Asn Tyr Glu Phe 
305                 310                 315                 320 


Phe Asp Thr Asp Glu Val Glu Glu Ala Ile Arg Glu Leu Thr Ala Gln 
                325                 330                 335     


Lys Arg His Ser Asp Arg Phe Pro Tyr Leu Ala Leu Arg Phe Leu Asp 
            340                 345                 350         


Glu Thr Met Ala Phe Ser Gln Leu Arg Phe Gln Leu Ser Leu Gly Lys 
        355                 360                 365             


Ile Ile Ile Lys Lys Pro Tyr Gln Lys Thr Ile Leu Gly Gln Pro Asn 
    370                 375                 380                 


Asp Arg Ile Ile Thr Lys Lys Leu Asn Val Phe Gly Arg Ile Ser Asp 
385                 390                 395                 400 


Phe Leu Asn Arg Glu Lys Glu Ile Ile Arg Ala Leu Ser Asn Asp Gln 
                405                 410                 415     


Asn Val Asp Phe Leu Glu Phe Glu Gln Phe Phe Pro His Tyr Asn Ile 
            420                 425                 430         


Asn Asn Asn Lys Ile Ala Phe Tyr Phe Leu Asn Asp Ser Asp Leu Thr 
        435                 440                 445             


Glu Glu Asn Leu Glu Ser Arg Leu Arg Asp Gln Glu Asn Arg Gln Pro 
    450                 455                 460                 


Thr Gly Phe Leu Ser Ile His Asp Leu Pro Lys Leu Val Leu Leu His 
465                 470                 475                 480 


Leu Leu Ala Pro Ser Glu Val Gln Lys Thr Leu Gln Arg Phe Ile Asn 
                485                 490                 495     


Asp Asn Asn Pro Ala Phe Phe Asp Leu Glu Leu Leu Ala Asn Ile Lys 
            500                 505                 510         


Ser Lys Val Val Tyr Glu Pro Ser Thr Phe Thr Lys Arg Ser Glu His 
        515                 520                 525             


Gln Tyr Arg Asp Ala Asp Lys Gln Glu Glu Glu Thr Glu Lys Gln Gln 
    530                 535                 540                 


Glu Tyr Gln Thr Leu Leu Asn Gln Arg Lys Arg Leu Leu Glu Gln His 
545                 550                 555                 560 


Leu Pro Lys Gly Val Lys Ile Asn Gln Ile Pro Glu Lys Val Leu Asp 
                565                 570                 575     


Phe Leu Met Asn Ile Ser Glu Pro Asn Glu Asn Lys Val Ile His Gln 
            580                 585                 590         


Lys Ile Lys Ser Ile Lys Asp Glu Ala Lys Thr Leu Leu Gln Arg Val 
        595                 600                 605             


Lys Asn Lys Gln Ala Ala Asn Glu Ile Pro Lys Leu Gly Glu Leu Ala 
    610                 615                 620                 


Thr Phe Leu Thr Arg Asp Ile Ile Asn Met Val Val Ser Glu Glu Leu 
625                 630                 635                 640 


Lys Lys Lys Ile Thr Ser Pro Tyr Ser Asn Lys Leu Gln Asn Lys Ile 
                645                 650                 655     


Ala Phe Phe Ser Leu Ser Lys Gln Glu Ile Ile Ser Leu Leu Ser Glu 
            660                 665                 670         


Leu Gln Leu Leu Asn Asn Glu Lys Gly His Val Phe Leu Ser Ser Arg 
        675                 680                 685             


Leu Ile Leu Glu Ser Asn Gly Leu Leu Ser Phe Tyr Lys Ser Tyr Leu 
    690                 695                 700                 


Glu Ala Lys Ile Ala Trp Ile Asp Lys Asn Leu Phe Leu Lys Gly Lys 
705                 710                 715                 720 


Lys Gly Gly Tyr Ile Ile Pro Glu Asn Lys Pro Val Pro Lys Thr Leu 
                725                 730                 735     


Gln Lys Ile Lys Gln Glu Val Ser Gln Phe Asp Phe Thr Gln Trp Leu 
            740                 745                 750         


Gln Asn Lys Ala Ala Met Pro Ile Asp Val Pro Asn Thr Ile Phe Asp 
        755                 760                 765             


Val Ser Leu Glu Asn Leu Leu Lys Thr Asn Leu Lys Lys Arg Gly Ile 
    770                 775                 780                 


Thr Val Lys Asp Thr Asp Lys Phe Ser Val Leu Leu Asn Lys Tyr Leu 
785                 790                 795                 800 


Asp Lys Asp Thr Gln Pro Phe Tyr Lys Tyr Gly Arg Val Tyr Lys Ile 
                805                 810                 815     


Gln Asp Glu Glu Glu Ser Val Gln Val Val Gly Lys Met Ser Lys Thr 
            820                 825                 830         


Leu Lys Lys Gln Tyr Gly Lys Phe Val Glu Glu Asn Glu Lys Val Ile 
        835                 840                 845             


Arg Phe Tyr Gln Ser Lys Asp Arg Val Ile Lys Leu Met Cys Asn Ala 
    850                 855                 860                 


Leu Leu Gln Ala Glu Asn Lys Thr Ala Leu Thr Asp Ser Phe Lys Leu 
865                 870                 875                 880 


Ala His Thr His Pro Asn Ser Lys Gln Asn Pro Leu Asp Thr Pro Met 
                885                 890                 895     


Arg Phe Glu Gln Lys Leu Phe Ser Asn Asp Lys Glu Thr Lys Val Leu 
            900                 905                 910         


Cys Thr Ile Tyr Ala Gln Asp Thr Glu Asn Gln Lys Asn Glu Ile Leu 
        915                 920                 925             


Ala Trp Asn Ser Leu Ser Glu Asp Asp Lys Lys Tyr Trp Leu Thr Leu 
    930                 935                 940                 


Thr Thr Lys Glu Ala Gln Lys Glu Trp Leu Ser Gly Lys Pro Glu Thr 
945                 950                 955                 960 


Glu Gln Glu Val Tyr His Gly Gln Lys Gly Tyr Gln Trp Thr Ile Lys 
                965                 970                 975     


Glu Val Gly Lys Phe Lys Arg Phe Val Lys Asp Arg Arg Ile Pro Ala 
            980                 985                 990         


Leu Val Asn Tyr Phe Glu Thr Thr  Lys Leu Pro Phe Ser  Leu Leu Glu 
        995                 1000                 1005             


Tyr Gln  Leu Lys Glu Tyr Asp  Arg Val Arg Glu Gln  Ile Phe Asp 
    1010                 1015                 1020             


Gly Val  Phe Lys Leu Glu Glu  Ala Ile Ser Gln Lys  Asp Leu Ala 
    1025                 1030                 1035             


Gly Ile  Trp Ala Leu Glu Gln  Glu Ala Arg Gly Arg  Lys Asn Tyr 
    1040                 1045                 1050             


His Gln  Val Gln Phe Asn Ile  Phe Glu Lys Tyr Leu  Gln Asn Thr 
    1055                 1060                 1065             


Leu Pro  Ser Tyr Asp Pro Ala  Ile Gly Val Ile Arg  Asn Lys Phe 
    1070                 1075                 1080             


Ser His  Asn Glu Phe Pro Asp  Leu Ile Gly Gln Gly  Ile Glu Lys 
    1085                 1090                 1095             


Ile Ser  Gln Ala Gln Ile Asp  Asp Tyr Gln Arg Asn  Lys His Leu 
    1100                 1105                 1110             


Lys Asp  Tyr Leu Ala His Ala  Gly Ile Ser Ile Ala  Gln Gln Ile 
    1115                 1120                 1125             


Leu Ala  Ile Phe Glu Gln Lys  Ile Asn Asp Thr Leu  Thr Gln Leu 
    1130                 1135                 1140             


Thr Thr  His Gly 
    1145         


<210>  2472
<211>  1132
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2472

Met Lys Glu Glu Glu Lys Gly Lys Thr Pro Val Val Ser Thr Tyr Asn 
1               5                   10                  15      


Lys Asp Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His 
            20                  25                  30          


Asn Val Tyr Ile Thr Ile Asn His Ile Asn Lys Leu Leu Glu Ile Arg 
        35                  40                  45              


Glu Ile Asp Asn Asp Glu Lys Val Leu Asp Ile Lys Ala Leu Trp Gln 
    50                  55                  60                  


Lys Gly Asn Lys Asp Leu Asn Gln Lys Ala Arg Leu Arg Glu Leu Met 
65                  70                  75                  80  


Thr Lys His Phe Pro Phe Leu Glu Thr Ala Ile Tyr Thr Lys Asn Lys 
                85                  90                  95      


Glu Asp Lys Lys Glu Val Lys Gln Glu Lys Gln Ala Glu Ala Gln Ser 
            100                 105                 110         


Leu Glu Ser Leu Lys Asp Cys Leu Phe Leu Phe Leu Glu Lys Leu Gln 
        115                 120                 125             


Glu Ala Arg Asn Tyr Tyr Ser His Tyr Lys Tyr Ser Glu Ser Thr Lys 
    130                 135                 140                 


Glu Pro Met Leu Glu Glu Gly Leu Leu Glu Lys Met Tyr Asn Ile Phe 
145                 150                 155                 160 


Asp Asp Asn Ile Gln Leu Val Ile Lys Asp Tyr Gln His Asn Lys Asp 
                165                 170                 175     


Ile Asn Pro Asp Glu Asp Phe Lys His Leu Asp Arg Lys Gly Gln Phe 
            180                 185                 190         


Lys Tyr Ser Phe Ala Asp Asn Glu Gly Asn Ile Thr Glu Ser Gly Leu 
        195                 200                 205             


Leu Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Met 
    210                 215                 220                 


Gln Gln Lys Leu Arg Gly Phe Lys Asp Asn Arg Glu Ser Lys Lys Lys 
225                 230                 235                 240 


Met Thr His Glu Val Phe Cys Arg Ser Arg Met Leu Leu Pro Lys Leu 
                245                 250                 255     


Arg Leu Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu 
            260                 265                 270         


Asn Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Lys Gly 
        275                 280                 285             


Glu Asp Arg Lys Lys Phe Glu Val Pro Phe Asp Ser Thr Asp Glu Asp 
    290                 295                 300                 


Tyr Asp Ala Glu Gln Asp Pro Phe Lys Asn Thr Leu Ile Arg His Gln 
305                 310                 315                 320 


Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Tyr Asn Glu Ile 
                325                 330                 335     


Phe Ala Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser 
            340                 345                 350         


Ile Tyr Lys Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg His Leu Thr 
        355                 360                 365             


His Lys Leu Tyr Gly Phe Glu Arg Ile Gln Glu Phe Ala Lys Gln Asn 
    370                 375                 380                 


Arg Thr Asp Glu Trp Lys Ala Leu Val Lys Asp Leu Asp Thr Tyr Glu 
385                 390                 395                 400 


Thr Ser Asn Glu Arg Tyr Ile Ser Glu Thr Thr Pro His Tyr His Leu 
                405                 410                 415     


Glu Asn Gln Lys Ile Gly Ile Arg Asn Lys Lys Lys Lys Lys Lys Lys 
            420                 425                 430         


Asn Ile Trp Pro Ser Leu Glu Thr Asn Thr Thr Val Asn Glu Lys Ser 
        435                 440                 445             


Lys Tyr Asn Leu Gly Lys Ser Phe Lys Ala Lys Ala Phe Leu Ser Val 
    450                 455                 460                 


His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Thr Lys Glu 
465                 470                 475                 480 


Glu Pro Asn Asn Lys Glu Ile Asn Ala Ser Lys Val Glu Gly Ile Ile 
                485                 490                 495     


Glu Lys Lys Ile Arg Asp Met Tyr Lys Leu Tyr Glu Ala Phe Ala Asn 
            500                 505                 510         


Gly Glu Ile Asn Ser Glu Asp Asp Leu Lys Lys Tyr Cys Lys Gly Lys 
        515                 520                 525             


Asp Ile Glu Met Val His Leu Pro Lys Gln Met Val Ala Ile Leu Lys 
    530                 535                 540                 


Asn Lys Pro Lys Asp Val Ala Glu Glu Ala Lys His Lys Gln Lys Lys 
545                 550                 555                 560 


Met Val Lys Ala Ala Glu Cys Lys Gln Arg Lys Met Val Lys Asp Thr 
                565                 570                 575     


Glu Lys Leu Leu Ala Ala Leu Glu Lys Gln Thr Gln Glu Glu Ile Glu 
            580                 585                 590         


Asp Gly Gly Arg Asn Ile Arg Leu Leu Lys Ser Gly Glu Ile Ala Arg 
        595                 600                 605             


Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln Lys Asp Asn 
    610                 615                 620                 


Glu Gly Asn Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln 
625                 630                 635                 640 


Met Leu Gln Arg Ser Leu Ala Leu Tyr Asn Lys Glu Glu Lys Pro Thr 
                645                 650                 655     


Arg Tyr Phe Lys Gln Val Asn Leu Ile Glu Ser Gly Asn Pro His Pro 
            660                 665                 670         


Phe Leu Asn Asn Thr Gly Trp Lys Glu Cys Asn Asn Ile Leu Ser Phe 
        675                 680                 685             


Tyr Arg Ser Tyr Leu Thr Lys Lys Ile Glu Phe Leu Asn Glu Leu Lys 
    690                 695                 700                 


Pro Glu Asp Trp Glu Lys Asn Gln Tyr Phe Leu Lys Leu Lys Glu Pro 
705                 710                 715                 720 


Lys Thr Asn Arg Glu Thr Leu Val Gln Gly Trp Lys Asn Gly Phe Asn 
                725                 730                 735     


Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg Glu Trp Phe Lys Arg 
            740                 745                 750         


His Gln Asn Asp Ser Glu Glu Tyr Lys Lys Val Glu Ala Leu Lys Arg 
        755                 760                 765             


Val Gly Leu Val Thr Lys Val Ile Pro Leu Phe Phe Lys Glu Glu Tyr 
    770                 775                 780                 


Ser Lys Asp Asp Ala Gln Lys Glu Ile Asn Asn Cys Val Gln Pro Phe 
785                 790                 795                 800 


Tyr Ser Leu Pro Tyr Asn Val Gly Asn Ile His Lys Pro Asp Glu Lys 
                805                 810                 815     


Asp Phe Leu His Arg Glu Glu Arg Ile Glu Leu Trp Gly Lys Lys Lys 
            820                 825                 830         


Asp Lys Phe Lys Gly Tyr Lys Ala Lys Lys Lys Pro Lys Lys Ile Thr 
        835                 840                 845             


Asp Glu Val Lys Glu Glu His Arg Ser Tyr Leu Glu Phe Gln Ser Trp 
    850                 855                 860                 


Asn Lys Phe Glu Arg Glu Leu Arg Leu Val Arg Asn Gln Asp Ile Val 
865                 870                 875                 880 


Thr Trp Leu Leu Cys Met Glu Leu Phe Asp Asn Leu Lys Val Glu Gly 
                885                 890                 895     


Leu Asn Val Glu Glu Leu Gln Lys Leu Arg Leu Lys Asp Ile Asp Thr 
            900                 905                 910         


Asp Thr Ala Lys Lys Asp Lys Asn Asn Ile Leu Asn Arg Ile Met Pro 
        915                 920                 925             


Met Gln Leu Pro Val Thr Val Tyr Glu Ile Asp Asp Ser His Asn Ile 
    930                 935                 940                 


Val Lys Asp Arg Pro Leu His Ser Val Tyr Ile Glu Glu Thr Lys Thr 
945                 950                 955                 960 


Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys Asp Arg Arg 
                965                 970                 975     


Leu Asn Gly Leu Phe Ser Phe Val Asp Thr Ser Ser Glu Ala Glu Leu 
            980                 985                 990         


Lys Ser Lys Pro Ile Ser Lys Ser  Val Val Glu Tyr Glu  Leu Gly Glu 
        995                 1000                 1005             


Tyr Gln  Asn Ala Arg Ile Glu  Thr Ile Lys Asp Met  Leu Leu Leu 
    1010                 1015                 1020             


Glu Glu  Thr Leu Ile Lys Lys  Tyr Lys Lys Leu Pro  Thr Asp Asn 
    1025                 1030                 1035             


Phe Ser  Asp Met Leu Asn Gly  Trp Leu Lys Gly Lys  Asp Glu Ala 
    1040                 1045                 1050             


Asp Lys  Ala Arg Phe Gln Asn  Asp Val Lys Leu Leu  Val Ala Val 
    1055                 1060                 1065             


Arg Asn  Ala Phe Ser His Asn  Gln Tyr Pro Met Arg  Asn Arg Ile 
    1070                 1075                 1080             


Ala Phe  Ala Asn Ile Asn Pro  Phe Ser Leu Ser Ser  Ala Asp Thr 
    1085                 1090                 1095             


Ser Glu  Glu Lys Lys Leu Asp  Ile Ala Asn Gln Leu  Lys Asp Lys 
    1100                 1105                 1110             


Thr Lys  Glu Thr Ile Asp Lys  Ile Ile Glu Ile Glu  Lys Pro Ile 
    1115                 1120                 1125             


Glu Thr  Lys Glu 
    1130         


<210>  2473
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2473

Met Gly Ala Ile Lys Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2474
<211>  1167
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2474

Met Glu Thr Lys Glu Gln Ile Gly Lys Asn Val Tyr Lys Thr Ser Glu 
1               5                   10                  15      


Asn Asp Pro Leu Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg His Asn 
            20                  25                  30          


Val Phe Leu Ile Ile Asn His Leu Thr Glu Val Phe Asp Ser Leu Gly 
        35                  40                  45              


Tyr Thr Lys Ile Asn Asp Asp Glu Asp Ile Val Asn Gln Asp His Ile 
    50                  55                  60                  


Leu Ser Gln Ile Phe Asp Pro Ser Lys Lys Glu Leu Glu Asn Glu Arg 
65                  70                  75                  80  


Ile Arg Ile Tyr Asn Tyr Met Ile Lys Arg His His Leu Pro Phe Leu 
                85                  90                  95      


Lys Val Phe Asn Ser Glu Ile Leu Asn Asp Glu Asp Gly Glu Asn Met 
            100                 105                 110         


Gly Ile Asp Phe Lys Ser Leu His Asn Phe Ile Ile Lys Ser Phe Lys 
        115                 120                 125             


Thr Leu Asn Asp Leu Arg Asn Ser Tyr Ser His Tyr Leu Ala Ile Asp 
    130                 135                 140                 


Asp Asp Gly Asn Lys Ile Glu Lys Arg Ser Asn Ile Val Asp Val Ser 
145                 150                 155                 160 


Ile Lys Ser Asp Ile Lys Gln Leu Phe Lys His Ala Pro Lys Phe Ser 
                165                 170                 175     


Phe Ile Arg Asn Gln Glu Thr Gln His Glu Glu Asp Tyr Asn His Leu 
            180                 185                 190         


Asp Arg Tyr Arg Ile Phe Glu Asn Glu Thr Asn Ile Leu Thr Asp Gln 
        195                 200                 205             


Gly Leu Tyr Phe Phe Ile Asn Leu Phe Leu Glu Arg Asn His Ala Thr 
    210                 215                 220                 


Lys Phe Leu Lys Lys Ile Lys Gly Phe Lys Asn Glu Thr Thr Pro Pro 
225                 230                 235                 240 


Phe Arg Ala Thr Ile Gln Ser Phe Thr Ser Phe Ala Leu Lys Leu Pro 
                245                 250                 255     


Asp Ile Arg Leu Ser Asn Glu Arg Pro Leu Phe Ser Leu Leu Met Asn 
            260                 265                 270         


Met Leu Thr Glu Leu Asn Lys Cys Pro Lys Glu Leu Phe Asn His Leu 
        275                 280                 285             


Thr Gln Lys Asp Lys Lys Glu Phe Glu Pro Leu Leu Asn Asp Glu Glu 
    290                 295                 300                 


Lys His Asn Val Val Leu Asn Ser Thr Asn Tyr Ser Glu Ile Ser Asp 
305                 310                 315                 320 


Asp Glu Leu Asp Glu Ala Ile Arg Glu Ile Thr Ala Leu Lys Arg Tyr 
                325                 330                 335     


Asn Asp Arg Phe Pro Tyr Phe Ala Leu Arg Phe Leu Asp Glu Thr Asn 
            340                 345                 350         


Ala Leu Lys Asn Ile Arg Phe Gln Ile Thr Leu Gly Lys Leu Ile Ile 
        355                 360                 365             


Lys Arg Tyr Asp Lys Glu Ile Ala Gly Ile Glu Glu Asn Arg Arg Val 
    370                 375                 380                 


Ile Lys Thr Ile Asn Ala Phe Gly Lys Leu Ser Asp Phe Ile Asp Asn 
385                 390                 395                 400 


Glu Glu Val Val Leu Lys Glu Leu Lys Lys Asn Leu Ala Asp Asn Asn 
                405                 410                 415     


Asp Ile Arg Phe Glu Gln Tyr Ser Pro His Tyr Asn Thr Asn Asn Ile 
            420                 425                 430         


Lys Ile Ala Phe Tyr Val Phe Asp Glu Gly Asp Asp Lys Thr Lys Tyr 
        435                 440                 445             


Pro Phe Val Phe Glu Asn Lys Glu Asn Asn Ser Asp Ile Gln Asn Asn 
    450                 455                 460                 


Pro Ser Gly Phe Leu Ser Ile His Asp Leu Pro Lys Met Leu Leu Phe 
465                 470                 475                 480 


Glu Cys Leu Asp Ile Asn Leu Lys Pro Glu Asn Ile Ile Ile Asp Phe 
                485                 490                 495     


Ile Arg Ser Thr Asn Leu Glu Met Phe Asp Leu Ser Glu Leu Glu Lys 
            500                 505                 510         


Ile Arg Lys Gln Ala Asn Tyr Glu Pro Glu Tyr Phe Ser Lys Arg Ile 
        515                 520                 525             


Asn Lys Glu Lys Tyr Leu Ile Ser Lys Lys Gly Ile Lys Tyr Leu Ser 
    530                 535                 540                 


Lys Glu Val Glu Asn Asn Met Leu Glu Asp Leu Gly Leu Ser Lys Asp 
545                 550                 555                 560 


Glu Leu Ile Leu Lys Asp Lys Asp Ser Phe Met Lys Leu Thr Asn Ser 
                565                 570                 575     


Lys Lys Tyr Ile Glu Tyr Phe Ser Gln Ile Lys Tyr Gln Tyr Tyr Leu 
            580                 585                 590         


Gln Lys Arg Arg Glu Glu Leu Gln Arg His Leu Pro Lys Gly Leu Lys 
        595                 600                 605             


Ile Asp Leu Leu Pro Glu Asn Ile Leu Glu Tyr Leu Met Asp Phe Lys 
    610                 615                 620                 


Glu Arg Asn Asn Glu Gly Ile Ile His Gln Lys Val Ala Ala Ile Arg 
625                 630                 635                 640 


Asp Glu Ala Lys Asn Leu Lys Lys Ser Ile Glu Ser Glu Val Glu Lys 
                645                 650                 655     


Pro Lys Asn Glu Gln Arg Ile Lys Leu Gly Glu Leu Ala Thr Phe Val 
            660                 665                 670         


Ala Arg Asp Ile Ile Lys Met Val Ile Cys Lys Glu Val Lys Asp Lys 
        675                 680                 685             


Ile Thr Ser Pro Tyr Tyr Asn Lys Leu Gln Asn Lys Ile Ala Tyr Phe 
    690                 695                 700                 


Ser Leu Asn Lys Asp Glu Leu Ile Asp Ile Cys Asp Glu Leu Lys Leu 
705                 710                 715                 720 


Phe Asn Glu Asn Glu Gly His Val Phe Phe Lys Lys Glu Leu Ile Lys 
                725                 730                 735     


Asn Ser Asp Gly Ile Ile Asp Phe Thr Leu Asp Tyr Leu Arg Ala Lys 
            740                 745                 750         


Asp Asn Trp Ile Glu Thr Lys Leu Leu Lys Lys Gly Lys Thr Gly Gly 
        755                 760                 765             


Tyr Arg Phe Pro Asp Lys Thr Lys Ile Pro Leu Ser Phe Asn Lys Ile 
    770                 775                 780                 


Lys Asn Lys Ala Asn Ser Phe Asp Phe Lys Thr Trp Leu Lys Asn Lys 
785                 790                 795                 800 


Ser Gln Leu Pro Val Asp Leu Pro Arg Ser Leu Phe Asp Glu Lys Leu 
                805                 810                 815     


Glu Ile Ile Leu Lys Gly Lys Leu Asn Gln Lys Gly Ile Ile Phe Asn 
            820                 825                 830         


Thr Gly Asp Lys Phe Ser Val Leu Leu Ser Lys Tyr Leu Asn Asn Asp 
        835                 840                 845             


Thr Gln Val Phe Tyr Asn Tyr Cys Arg Ser Tyr Ser Ile Asn Lys Lys 
    850                 855                 860                 


Ile Glu Glu Phe Glu Ile Ser Gly Leu Ser Gly Lys Glu Ile Lys Lys 
865                 870                 875                 880 


Asn Phe Asp Ser Asn Val Glu Lys Asn Glu Lys Ser Ile Arg Phe Ile 
                885                 890                 895     


Gln Thr Lys Asp Arg Val Leu Lys Leu Ile Ser Asp Lys Ile Leu Ser 
            900                 905                 910         


Ile Asp Arg Ser Ile Gly Leu Gln Ser Gly Phe Cys Leu Thr Asp Ile 
        915                 920                 925             


His Pro Ala Ala Lys His Asn Pro Leu Asp Cys Pro Ala Val Phe Glu 
    930                 935                 940                 


Gln Lys Ile Ile Arg Arg Gly Asp Glu Val Phe Cys Asn Ile Ile Ala 
945                 950                 955                 960 


Lys Asp Thr Glu Asn Gln Ile Gln Ser Val Lys His Phe Glu Ser Leu 
                965                 970                 975     


Gln Ala Glu Glu Glu Lys Glu Ala Tyr Pro Asp Gln Lys Trp Tyr Gln 
            980                 985                 990         


Trp Thr Ile Lys Asp Phe Gly Arg  Phe Lys Arg Phe Ile  Lys Asp Arg 
        995                 1000                 1005             


Arg Ile  Pro Asn Leu Ser Asn  Tyr Phe Glu Asp Lys  Asn Ile Pro 
    1010                 1015                 1020             


Phe Asp  Leu Leu Glu Tyr Gln  Leu Arg Glu Tyr Asn  Lys Tyr Lys 
    1025                 1030                 1035             


Glu Glu  Ile Phe Glu Leu Thr  Leu Met Leu Glu Lys  Glu Ile Ile 
    1040                 1045                 1050             


Asn Tyr  Asp Phe Glu Gly Ile  Arg Thr Ile Glu Phe  Ser Glu Asn 
    1055                 1060                 1065             


Arg Arg  Pro Lys Gly Phe Tyr  Glu Ile Arg Phe Asp  Thr Tyr Met 
    1070                 1075                 1080             


Glu Trp  Leu Asp Asn Lys Asn  Ile Gln Tyr Asn Lys  Glu Arg Val 
    1085                 1090                 1095             


Lys Glu  Cys Arg Asn Lys Phe  Ser His Ser Glu Tyr  Pro Leu Phe 
    1100                 1105                 1110             


Lys Glu  Ile Ser Lys Ile Ser  Lys Gln Gln Ile Thr  Glu Phe Glu 
    1115                 1120                 1125             


Thr Asn  Lys Gln Ile Lys Asp  Tyr Lys Ser Ser Ser  Gly Ile Ser 
    1130                 1135                 1140             


Ile Ala  Glu Lys Ile Tyr Asn  Leu Tyr Lys Leu Glu  Ile Glu Arg 
    1145                 1150                 1155             


Ile Ile  Asn Ser Ile Lys Asn  Asn Ile 
    1160                 1165         


<210>  2475
<211>  1142
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2475

Met Glu Ala His Glu Asn Glu Leu Phe Glu Asn Arg Arg Arg Thr Leu 
1               5                   10                  15      


Ala Asp Asp Pro Gln Tyr Phe Gly Ala Tyr Met Asn Leu Ala Arg Leu 
            20                  25                  30          


Asn Ile Phe Ser Ile Asn Asn Tyr Leu Ala Lys Glu Phe Gln Gln Thr 
        35                  40                  45              


Glu Leu Lys Asp Asp Glu Leu Ile Gln Asn Gly Phe Ile Cys Ile Pro 
    50                  55                  60                  


Ser Gln Lys Asn Arg Asn Asp Asn Lys Leu Phe Glu Arg Leu Ile Arg 
65                  70                  75                  80  


Leu Met Pro Val Ile Lys Gln Phe Asp Ala Ala Arg Leu Pro Asp Glu 
                85                  90                  95      


Glu Gln Lys Ser Gly Gln Ala Glu Gly Lys Asp Ile Lys Ala Met Ala 
            100                 105                 110         


Lys Thr Leu Lys Val Leu Phe Lys Asp Met Gln Glu Phe Arg Asn Asp 
        115                 120                 125             


Tyr Thr His Phe Tyr Ala Thr Asp Lys Gln Glu Cys Arg Lys Leu Thr 
    130                 135                 140                 


Val Ser Pro Glu Thr Ala Thr Phe Leu Lys Glu Ser Phe Ala Arg Ala 
145                 150                 155                 160 


Ile Glu Tyr Ser Lys Ala Arg Phe Lys Asp Val Leu Ala Glu Asp Asp 
                165                 170                 175     


Tyr Thr Leu Val Ala Gly Lys Glu Leu Val Gly Asp Asp Asn Thr Ile 
            180                 185                 190         


Thr Thr Glu Gly Leu Val Phe Leu Thr Ser Leu Phe Leu Asp Arg Glu 
        195                 200                 205             


Asn Ala Phe Gln Phe Ile Gly Lys Val Gln Gly Leu Lys Gly Thr Gln 
    210                 215                 220                 


Phe Lys Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ala Tyr Cys Val 
225                 230                 235                 240 


Arg Leu Pro His Asp Lys Leu Ile Ser Asp Asn Pro Arg Gln Ala Leu 
                245                 250                 255     


Leu Phe Asp Met Leu Asn Glu Leu Asn Lys Cys Pro Lys Lys Leu Tyr 
            260                 265                 270         


Asn Val Leu Ser Asp Glu Ala Lys Arg Glu Phe Arg Pro Glu Leu Ser 
        275                 280                 285             


Glu Ser Gly Ile Glu Asn Met Leu Ala Asn Ser Phe Asn Asp Glu Glu 
    290                 295                 300                 


Arg Glu Arg Leu Leu Asp Glu Ile Asp Tyr Lys Asp Tyr Ile Lys Gln 
305                 310                 315                 320 


Leu Thr Ile Arg Val Arg His Ser Asn Arg Phe His Tyr Phe Ala Met 
                325                 330                 335     


Arg Phe Ile Asp Glu Gln Glu Leu Trp Ser Gly Ile Arg Phe Gln Ile 
            340                 345                 350         


Asp Leu Gly Lys Tyr Ile Leu Ala Asn Tyr Gln Lys Gln Met Leu Gly 
        355                 360                 365             


Glu Ser Ile Pro Arg Ser Val Val Glu Asn Ala Lys Ala Phe Gly Arg 
    370                 375                 380                 


Leu Gly Ser Phe Leu Met Ala Asp Pro Asp Ser Leu Glu Gln Arg Ile 
385                 390                 395                 400 


Asp Ser Asn His Gln Ala Asn Gly Phe Glu Gln Phe Ala Pro His Tyr 
                405                 410                 415     


Asn Ala Asp Ile Asn Lys Ile Gly Ile Ser Phe Thr Glu Lys Glu Glu 
            420                 425                 430         


Leu Leu Pro Tyr Ile Val Pro Thr Lys Asn Glu Lys Glu Asn Arg Val 
        435                 440                 445             


Lys Tyr Ser Phe Lys Gln Pro Gln Pro Asn Ala Phe Ile Ser Leu His 
    450                 455                 460                 


Glu Leu Ala Lys Ala Ile Leu Leu Glu Gln Leu Gln Pro Gly Glu Ser 
465                 470                 475                 480 


Glu Lys Leu Ile Arg Ala Phe Cys Ser Thr Ala Glu Asn Lys Leu Phe 
                485                 490                 495     


Asn Leu Asp Phe Ile Glu Ser Ile Lys Gln Lys Leu Pro Asp Trp Arg 
            500                 505                 510         


Thr Phe Asn Lys Gln Cys Asp Thr Lys Lys Arg Arg Ala Tyr Met Cys 
        515                 520                 525             


Ile Lys Asn Arg Gln Leu Val Phe Asn Tyr Glu Ala Lys Asp Arg Lys 
    530                 535                 540                 


Lys Leu Leu Asp Glu Leu Leu Ala Pro Tyr Gly Leu Asn Ser Lys Gln 
545                 550                 555                 560 


Val Pro Glu Arg Ile Leu Asn Tyr Trp Leu Asn Ile Glu Glu Val His 
                565                 570                 575     


Asp Ala Arg Ser Ile Lys Glu Arg Ile Leu Leu Met Lys Arg Asp Gly 
            580                 585                 590         


Leu Gln Arg Leu Lys Gln Leu Glu Lys His Arg Lys Asp Pro Ser Val 
        595                 600                 605             


Arg Ile Pro Lys Val Gly Glu Met Ala Thr Phe Leu Ala Arg Asp Ile 
    610                 615                 620                 


Val Asp Met Met Ile Asp Ser Ile Lys Lys Lys Lys Ile Thr Ser Ile 
625                 630                 635                 640 


Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Phe Tyr Ala Asp Ala Glu 
                645                 650                 655     


Lys Arg Gln Gln Phe Ile Asn Leu Val Arg Glu Leu Asn Leu Asn Ala 
            660                 665                 670         


Pro Asp Ser His Pro Phe Leu Lys Asn Leu Asn Leu Glu Ser Ile Arg 
        675                 680                 685             


Lys Thr Ser Glu Phe Tyr Lys Leu Tyr Leu Met Glu Lys Val Glu Lys 
    690                 695                 700                 


Met Ile Glu Asn Gly Tyr Lys Arg Asn Gly Asp Lys Ser Phe Lys Asn 
705                 710                 715                 720 


Ile Ala Trp Ile Ile Arg Val Phe Glu Glu Lys Gln Lys Asn Glu Lys 
                725                 730                 735     


Thr Gly Lys Asp Asp Thr Ile Tyr Arg Ile Pro Asn Asn Arg Asn Asp 
            740                 745                 750         


Val Pro Tyr Thr Ile Arg Gln Trp Glu Lys Glu Pro Ser Thr Leu Thr 
        755                 760                 765             


Glu Trp Leu Arg Ser Ile Asn His Gly Lys Gln Glu Gly Asp Arg Lys 
    770                 775                 780                 


Arg Pro Ile Asp Leu Pro Thr Asp Leu Phe Asp Ala Arg Leu Cys Lys 
785                 790                 795                 800 


Leu Met Lys Glu Gln Leu Gln Ala Ile Gly Gln Ala Pro Ala Glu Thr 
                805                 810                 815     


Ala Lys Tyr Asn Glu Val Met Lys Gln Trp Trp Ser Val Arg Gly Asp 
            820                 825                 830         


Glu Thr Gln Pro Phe Tyr Asn Gly Ala Arg His Tyr Val Ile Lys Glu 
        835                 840                 845             


Glu Ala Val Cys Phe Met Pro Gly Lys Gln Glu Arg Leu Thr Ser Cys 
    850                 855                 860                 


Tyr Ala Gly Ala Phe Glu Glu Ala Tyr Asn Arg Leu Ser Ala Glu Arg 
865                 870                 875                 880 


Asn Ile Ala Arg Arg Asn Asp Lys Arg Leu Pro Pro Ile Gln Lys Gln 
                885                 890                 895     


Glu Met Glu Lys Thr Phe Lys Arg Val Leu Tyr Asp Thr Glu Lys Glu 
            900                 905                 910         


Ile Arg Leu Leu Ser Glu Gln Asp Arg Ile Leu Leu Leu Met Ala Glu 
        915                 920                 925             


Gln Leu Ser Pro Gly Lys Glu Thr Leu Lys Leu Lys Thr Val Glu Glu 
    930                 935                 940                 


Glu Leu Thr Arg Pro Arg Glu Ile Glu Arg Glu Phe Ser Tyr Lys Ala 
945                 950                 955                 960 


Asn Tyr Asn Thr Gln Gly Lys Lys Leu Pro Lys Glu Glu Val Ser Pro 
                965                 970                 975     


Gln Leu Thr Leu Thr Val Thr Asp Thr Met Gln Leu Lys Asn Ser Asn 
            980                 985                 990         


Asn Leu Asn Arg Phe Ala His Asp  Arg Arg Met Pro Glu  Leu Val Ala 
        995                 1000                 1005             


Tyr Leu  Pro Asn Ala Thr Ile  Asp Ala Asp Thr Leu  Arg Tyr Glu 
    1010                 1015                 1020             


Leu Met  Asp Tyr Asn Lys Ala  Arg Leu Thr Val Phe  Asp Thr Ile 
    1025                 1030                 1035             


Phe His  Leu Glu Lys Ala Ile  Val Asp Lys Asp Ser  Glu Gly Val 
    1040                 1045                 1050             


Ile Thr  Leu Phe Thr Asp Glu  Gln Gly Glu Ala Lys  Gln Gly Arg 
    1055                 1060                 1065             


Met Gln  His Lys Pro Tyr Leu  Gln Trp Leu Leu Leu  Asn Gly Val 
    1070                 1075                 1080             


Ile Thr  Glu Gln Glu Ser Cys  Tyr Leu Asn Met Leu  Arg Asn Ser 
    1085                 1090                 1095             


Phe Ser  His Asn Gln Phe Pro  His Ile Ala Val Ala  Thr Ser Asp 
    1100                 1105                 1110             


Ala Thr  Ala Ile Pro Val Lys  Asn Ile Ala Ser Ala  Ile Ala Lys 
    1115                 1120                 1125             


Thr Tyr  Lys Gln Lys Ile Glu  Thr Ile Ile Gly Lys  Ile Gly 
    1130                 1135                 1140         


<210>  2476
<211>  1175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2476

Met Thr Glu Gln Asn Glu Arg Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Thr His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Asn Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro Arg Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Tyr Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Glu Lys Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Ala Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Asp Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Phe Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Asp Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Gly Glu Ile Asp Thr Arg Asp 
    530                 535                 540                 


Glu Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Ser Glu Phe His Leu 
            740                 745                 750         


Pro Arg Ala Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Leu Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asn Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Glu Arg Ile Lys Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Asp Leu Glu Ala Trp Ser His Gly Ala Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Val Gly Ile Glu Tyr Ala Ser Pro Gly Asn 
    850                 855                 860                 


Lys Lys Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Glu Thr 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Lys Ala Asp Lys Ile Asn Ile Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Ala Lys Glu His Pro Tyr Leu Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asp Ile Arg Thr 
945                 950                 955                 960 


Asp Val His Glu Gln Gly Ser Leu Asn Val Leu Asn Arg Val Lys Pro 
                965                 970                 975     


Met Arg Leu Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val 
            980                 985                 990         


His Lys Glu Gln Ala Pro Leu Ala  Thr Val Tyr Ile Glu  Glu Arg Asp 
        995                 1000                 1005             


Thr Lys  Leu Leu Lys Gln Gly  Asn Phe Lys Ser Phe  Val Lys Asp 
    1010                 1015                 1020             


Arg Arg  Leu Asn Gly Leu Phe  Ser Phe Val Asp Thr  Gly Ala Leu 
    1025                 1030                 1035             


Ala Met  Glu Gln Tyr Pro Ile  Ser Lys Leu Arg Val  Glu Tyr Glu 
    1040                 1045                 1050             


Leu Ala  Lys Tyr Gln Thr Ala  Arg Val Cys Ala Phe  Glu Gln Thr 
    1055                 1060                 1065             


Leu Gly  Leu Glu Glu Ser Leu  Leu Thr Arg Tyr Pro  His Leu Pro 
    1070                 1075                 1080             


Asp Lys  Asn Phe Arg Lys Met  Leu Glu Ser Trp Ser  Asp Pro Leu 
    1085                 1090                 1095             


Leu Asp  Lys Trp Pro Asp Leu  His Gly Asn Val Arg  Leu Leu Ile 
    1100                 1105                 1110             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1115                 1120                 1125             


Glu Thr  Leu Phe Ser Ser Ile  Arg Lys Tyr Asp Pro  Ser Ser Pro 
    1130                 1135                 1140             


Asp Ala  Ile Glu Glu Arg Met  Gly Leu Asn Ile Ala  His Arg Leu 
    1145                 1150                 1155             


Ser Glu  Glu Val Lys Gln Ala  Lys Glu Met Val Glu  Arg Ile Ile 
    1160                 1165                 1170             


Gln Ala  
    1175 


<210>  2477
<211>  1147
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2477

Met Glu Ile Ala Thr Gln Gln Ser Glu Thr Gln Lys Lys Lys Arg Ser 
1               5                   10                  15      


Leu Asp Gln Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg 
            20                  25                  30          


His Asn Val Phe Leu Ile Val Asn His Leu Thr Asp Thr Phe Lys Glu 
        35                  40                  45              


Leu Asn Phe Lys Lys Leu Ala Asn Glu Glu Asp Ile Trp Lys Val Asp 
    50                  55                  60                  


Asn Ser Ser Asn Ile Leu Leu Asn Val Phe Asp Val Thr Gln Ser Lys 
65                  70                  75                  80  


Tyr Glu Asp Phe Arg Pro Arg Ile Phe His Tyr Leu Ile Lys Arg His 
                85                  90                  95      


His Leu Pro Leu Val Lys Ile Phe Asn Thr Glu Tyr Leu Gly Glu Asn 
            100                 105                 110         


Ile Leu Gln Asp Lys Ser Ile Asp Tyr Glu Arg Leu His Gln Phe Leu 
        115                 120                 125             


Cys Leu Ser Phe Lys Glu Leu Thr Glu Phe Arg Asn Ser Tyr Ser His 
    130                 135                 140                 


Ser Ile Ala Ile Asp Glu Asn Gly Asn Lys Val Gly Arg Lys Thr Thr 
145                 150                 155                 160 


Leu Ala Asn Asp Leu Val Pro Glu Val Asn Leu Leu Phe Lys Tyr Ala 
                165                 170                 175     


Pro Lys Tyr Ser Phe Leu Arg Asn His Gln Thr Leu Asn Glu Gly Asp 
            180                 185                 190         


Phe Gln His Leu Asp Asn Tyr Gln Leu Phe Ile Ala Asp Asn Gln Leu 
        195                 200                 205             


Thr His Gln Gly Arg Phe Phe Phe Ile Asn Leu Phe Leu Glu Arg Ser 
    210                 215                 220                 


Tyr Gly Ile Lys Phe Leu Lys Arg Phe Arg Gly Phe Lys Asn Glu Asn 
225                 230                 235                 240 


Thr Pro Pro Phe Lys Ala Thr Ile Gln Ser Phe Thr Thr Tyr Cys Leu 
                245                 250                 255     


Lys Val Pro Asp Ile Arg Leu Gly Asn Glu Asn Pro Lys Gln Ser Leu 
            260                 265                 270         


Leu Leu Asp Met Leu Thr Glu Leu Asn Lys Cys Pro Lys Glu Leu Phe 
        275                 280                 285             


Asn His Leu Thr Glu Asp Asp Lys Lys Glu Phe Glu Pro Asn Leu Asp 
    290                 295                 300                 


Glu Thr Ser Ser Thr Asn Val Leu Leu Asn Ser Thr Asn Tyr Glu Phe 
305                 310                 315                 320 


Phe Asp Thr Asp Glu Val Glu Glu Ala Ile Arg Glu Leu Thr Ala Gln 
                325                 330                 335     


Lys Arg His Ser Asp Arg Phe Pro Tyr Leu Ala Leu Arg Phe Leu Asp 
            340                 345                 350         


Glu Thr Met Ala Phe Ser Gln Leu Arg Phe Gln Leu Ser Leu Gly Lys 
        355                 360                 365             


Ile Ile Ile Lys Lys Pro Tyr Gln Lys Thr Ile Leu Gly Gln Pro Asn 
    370                 375                 380                 


Asp Arg Ile Ile Thr Lys Lys Leu Asn Val Phe Gly Arg Ile Ser Asp 
385                 390                 395                 400 


Phe Leu Asn Arg Glu Lys Glu Ile Ile Arg Ala Leu Ser Asn Asp Gln 
                405                 410                 415     


Asn Val Asp Phe Leu Glu Phe Glu Gln Phe Phe Pro His Tyr Asn Ile 
            420                 425                 430         


Asn Asn Asn Lys Ile Ala Phe Tyr Phe Leu Asn Asp Ser Asp Leu Thr 
        435                 440                 445             


Glu Glu Asn Leu Glu Ser Arg Leu Arg Asp Gln Glu Asn Arg Gln Pro 
    450                 455                 460                 


Thr Gly Phe Leu Ser Ile His Asp Leu Pro Lys Leu Val Leu Leu His 
465                 470                 475                 480 


Leu Leu Ala Pro Ser Glu Val Gln Lys Thr Leu Gln Arg Phe Ile Asn 
                485                 490                 495     


Asp Asn Asn Pro Ala Phe Phe Asp Leu Glu Leu Leu Ala Asn Ile Lys 
            500                 505                 510         


Ser Lys Val Val Tyr Glu Pro Ser Thr Phe Thr Lys Arg Ser Glu His 
        515                 520                 525             


Gln Tyr Arg Asp Ala Asp Lys Gln Glu Glu Glu Thr Glu Lys Gln Gln 
    530                 535                 540                 


Glu Tyr Gln Thr Leu Leu Asn Gln Arg Lys Arg Leu Leu Glu Gln His 
545                 550                 555                 560 


Leu Pro Lys Gly Val Lys Ile Asn Gln Ile Pro Glu Lys Val Leu Asp 
                565                 570                 575     


Phe Leu Met Asn Ile Ser Glu Pro Asn Glu Asn Lys Val Ile His Gln 
            580                 585                 590         


Lys Ile Lys Ser Ile Lys Asp Glu Ala Lys Thr Leu Leu Gln Arg Val 
        595                 600                 605             


Lys Asn Lys Gln Ala Ala Asn Glu Ile Pro Lys Leu Gly Glu Leu Ala 
    610                 615                 620                 


Thr Phe Leu Thr Arg Asp Ile Ile Asn Met Val Val Ser Glu Glu Leu 
625                 630                 635                 640 


Lys Lys Lys Ile Thr Ser Pro Tyr Ser Asn Lys Leu Gln Asn Lys Ile 
                645                 650                 655     


Ala Phe Phe Ser Leu Ser Lys Gln Glu Ile Ile Ser Leu Leu Ser Glu 
            660                 665                 670         


Leu Gln Leu Leu Asn Asn Glu Lys Gly His Val Phe Leu Ser Ser Arg 
        675                 680                 685             


Leu Ile Leu Glu Ser Asn Gly Leu Leu Ser Phe Tyr Lys Ser Tyr Leu 
    690                 695                 700                 


Glu Ala Lys Ile Ala Trp Ile Asp Lys Asn Leu Phe Leu Lys Gly Lys 
705                 710                 715                 720 


Lys Gly Gly Tyr Ile Ile Pro Glu Asn Lys Pro Val Pro Lys Thr Leu 
                725                 730                 735     


Gln Lys Ile Lys Gln Glu Val Ser Gln Phe Asp Phe Thr Gln Trp Leu 
            740                 745                 750         


Gln Asn Lys Ala Ala Met Pro Ile Asp Val Pro Asn Thr Ile Phe Asp 
        755                 760                 765             


Val Ser Leu Glu Asn Leu Leu Lys Thr Asn Leu Lys Lys Arg Gly Ile 
    770                 775                 780                 


Thr Val Lys Asp Thr Asp Lys Phe Ser Val Leu Leu Asn Lys Tyr Leu 
785                 790                 795                 800 


Asp Lys Asp Thr Gln Pro Phe Tyr Lys Tyr Gly Arg Val Tyr Lys Ile 
                805                 810                 815     


Gln Asp Glu Glu Glu Ser Val Gln Val Val Gly Lys Met Ser Lys Thr 
            820                 825                 830         


Leu Lys Lys Gln Tyr Gly Lys Phe Val Glu Glu Asn Glu Lys Val Ile 
        835                 840                 845             


Arg Phe Tyr Gln Ser Lys Asp Arg Val Ile Lys Leu Met Cys Asn Ala 
    850                 855                 860                 


Leu Leu Gln Ala Glu Asn Lys Thr Ala Leu Thr Asp Ser Phe Lys Leu 
865                 870                 875                 880 


Ala His Thr His Pro Asn Ser Lys Gln Asn Pro Leu Asp Thr Pro Met 
                885                 890                 895     


Arg Phe Glu Gln Lys Leu Phe Ser Asn Asp Lys Glu Thr Lys Val Leu 
            900                 905                 910         


Cys Thr Ile Tyr Ala Gln Asp Thr Glu Asn Gln Lys Asn Glu Ile Leu 
        915                 920                 925             


Ala Trp Asn Ser Leu Ser Glu Asp Asp Lys Lys Tyr Trp Leu Thr Leu 
    930                 935                 940                 


Thr Thr Lys Glu Ala Gln Lys Glu Trp Leu Ser Gly Lys Pro Glu Thr 
945                 950                 955                 960 


Glu Gln Glu Val Tyr His Gly Gln Lys Gly Tyr Gln Trp Thr Ile Lys 
                965                 970                 975     


Glu Val Gly Lys Phe Lys Arg Phe Val Lys Asp Arg Arg Ile Pro Ala 
            980                 985                 990         


Leu Val Asn Tyr Phe Glu Thr Thr  Lys Leu Pro Phe Ser  Leu Leu Glu 
        995                 1000                 1005             


Tyr Gln  Leu Lys Glu Tyr Asp  Arg Val Arg Glu Gln  Ile Phe Asp 
    1010                 1015                 1020             


Gly Val  Phe Lys Leu Glu Glu  Ala Ile Ser Gln Lys  Asp Leu Ala 
    1025                 1030                 1035             


Gly Ile  Trp Ala Leu Glu Gln  Glu Ala Arg Gly Arg  Lys Asn Tyr 
    1040                 1045                 1050             


His Gln  Val Gln Phe Asn Ile  Phe Glu Lys Tyr Leu  Gln Asn Thr 
    1055                 1060                 1065             


Leu Pro  Ser Tyr Asp Pro Ala  Ile Gly Val Ile Arg  Asn Lys Phe 
    1070                 1075                 1080             


Ser His  Asn Glu Phe Pro Asp  Leu Ile Gly Gln Gly  Ile Glu Lys 
    1085                 1090                 1095             


Ile Ser  Gln Ala Gln Ile Asp  Asp Tyr Gln Arg Asn  Lys His Leu 
    1100                 1105                 1110             


Lys Asp  Tyr Leu Ala His Ala  Gly Ile Ser Ile Ala  Gln Gln Ile 
    1115                 1120                 1125             


Leu Ala  Ile Phe Glu Gln Lys  Ile Asn Asp Thr Leu  Thr Gln Leu 
    1130                 1135                 1140             


Thr Thr  His Gly 
    1145         


<210>  2478
<211>  1091
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2478

Met Lys Glu Glu Glu Lys Gly Lys Thr Pro Val Val Ser Thr Tyr Asn 
1               5                   10                  15      


Lys Asp Asn Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His 
            20                  25                  30          


Asn Val Tyr Ile Thr Val Asn His Ile Asn Lys Ile Leu Gly Glu Ala 
        35                  40                  45              


Glu Ile Asn Ile Asp Gly Tyr Asp Ile Ser Leu Lys Asn Ile Trp Ser 
    50                  55                  60                  


Gly Ile Arg Asp Ile Asn Lys Lys Ala Arg Leu Glu Glu Leu Met Ile 
65                  70                  75                  80  


Lys His Phe Pro Phe Leu Glu Ala Met Thr His Gln Gln Arg Leu Thr 
                85                  90                  95      


Gly Asn Thr Lys Gln Lys Glu Glu Lys Gln Ala Lys Ile Gln Ser Phe 
            100                 105                 110         


Glu Ile Leu Lys Asp Asn Leu Phe Leu Leu Leu Lys Met Leu Gln Asp 
        115                 120                 125             


Leu Arg Asn His Tyr Ser His Tyr Lys His Ser Lys Ser Leu Glu Arg 
    130                 135                 140                 


Pro Lys Phe Asp Glu Asp Ile Arg Asn Lys Leu Tyr Asn Ile Phe Asp 
145                 150                 155                 160 


Thr Ser Ile Arg Leu Val Lys Glu Asp Tyr Lys His Asn Pro Asp Ile 
                165                 170                 175     


Lys Pro Lys Glu His Phe Lys His Leu Asp Arg Lys Arg Asn Glu Lys 
            180                 185                 190         


Phe Arg Tyr Ser Phe Ala Asp Asn Glu Gly Asn Ile Thr Ile Ser Gly 
        195                 200                 205             


Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp 
    210                 215                 220                 


Val Gln Lys Lys Leu Glu Gly Phe Arg Cys Ser Asn Glu Ser Tyr Gln 
225                 230                 235                 240 


Lys Met Thr Asn Glu Val Phe Cys Arg Asn Arg Ile Leu Met Pro Lys 
                245                 250                 255     


Leu Arg Leu Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met 
            260                 265                 270         


Leu Asn Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Lys 
        275                 280                 285             


Gly Glu Asp Arg Lys Lys Phe Glu Val Pro Phe Asp Ser Thr Asp Glu 
    290                 295                 300                 


Asp Tyr Asp Ala Glu Gln Asp Pro Phe Lys Asn Thr Leu Ile Arg His 
305                 310                 315                 320 


Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe Asp Tyr Asn Glu 
                325                 330                 335     


Ile Phe Glu Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe 
            340                 345                 350         


Ser Ile Tyr Lys Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg His Leu 
        355                 360                 365             


Thr His Lys Leu Tyr Gly Phe Glu Arg Leu Gln Glu Phe Ala Lys Gln 
    370                 375                 380                 


Asn Arg Pro Asp Glu Trp Lys Ala Ile Ile Lys Asp Leu Asp Thr Phe 
385                 390                 395                 400 


Lys Lys Gln Glu Asp Glu Lys Val Asn Glu Lys Pro Tyr Ile Ser Glu 
                405                 410                 415     


Thr Thr Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Ala Phe 
            420                 425                 430         


Lys Asn His Asn Ile Trp Pro Thr Thr Asn Thr Glu Leu Thr Asn Asn 
        435                 440                 445             


Lys Arg Lys Lys Tyr Asn Leu Gly Thr Ser Ile Lys Ala Glu Ala Phe 
    450                 455                 460                 


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Met Leu Leu 
465                 470                 475                 480 


Lys Thr Lys Asn Glu Ser Pro Arg Lys Val Glu Ala Ile Ile Glu Ser 
                485                 490                 495     


Lys Ile Lys Asp Ile Phe Thr Leu Tyr Asp Ala Phe Ala Asn Asp Glu 
            500                 505                 510         


Ile Asp Asn Thr Asp Lys Leu Glu Lys Tyr Cys Glu Asp Thr Asp Ile 
        515                 520                 525             


Lys Ile Gly His Leu Pro Lys Gln Met Ile Ala Ile Leu Tyr Asn Lys 
    530                 535                 540                 


His Lys Asp Met Val Glu Lys Ala Lys Val Lys Gln Glu Lys Met Lys 
545                 550                 555                 560 


Leu Ala Thr Glu Asn Arg Leu Lys Thr Leu Asp Lys Leu Ile Glu Gly 
                565                 570                 575     


Lys Met Lys Tyr Ala Lys Arg Gly Ile Ser Pro Leu Lys Ser Gly Glu 
            580                 585                 590         


Ile Ala Ser Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln 
        595                 600                 605             


Arg Asp Glu Asn Gly Glu Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr 
    610                 615                 620                 


Glu Tyr Gln Leu Leu Gln Arg Thr Leu Ala Leu Phe Gly Ser Glu His 
625                 630                 635                 640 


Lys Arg Leu Thr Pro Tyr Phe Lys Gln Met Asn Leu Ile Gly Asp Asn 
                645                 650                 655     


Asn Ser His Pro Phe Leu Lys Gln Thr Glu Trp Glu Glu Cys Asn Asn 
            660                 665                 670         


Ile Leu Ser Phe Tyr Arg Ser Tyr Leu Glu Ala Arg Lys Asn Phe Leu 
        675                 680                 685             


Lys Asn Leu Glu Pro Lys Asp Trp Lys Lys Asn Gln Tyr Phe Leu Lys 
    690                 695                 700                 


Ile Lys Glu Pro Lys Ser Asn Arg Gln Thr Leu Val Gln Gly Trp Lys 
705                 710                 715                 720 


Asn Gly Phe Asn Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Lys Lys 
                725                 730                 735     


Trp Phe Ile Glu His Arg Lys Lys Met Lys Val Asp Glu Leu Lys Ser 
            740                 745                 750         


Val Gly Leu Val Ala Lys Val Ile Pro Leu Tyr Phe Asn Glu Lys Tyr 
        755                 760                 765             


Lys Asp Ser Val Gln Pro Phe Tyr Asn Tyr Pro Phe Asn Val Gly Asp 
    770                 775                 780                 


Ile Asn Lys Pro Lys Glu Lys Asp Phe Leu Asp Asn Gly Lys Arg Arg 
785                 790                 795                 800 


Lys Leu Trp Asp Lys Lys Gln Leu Glu Phe Lys Gly Lys Thr Glu Glu 
                805                 810                 815     


Glu Lys Arg Lys Asn Pro Ser Tyr Leu Asp Phe Lys Ser Trp Lys Lys 
            820                 825                 830         


Phe Glu Arg Glu Leu Arg Leu Ile Arg Asn Gln Asp Ile Val Thr Trp 
        835                 840                 845             


Leu Met Cys Ile Glu Leu Tyr Asn Asn Gln Lys Val Glu Asn Leu Asn 
    850                 855                 860                 


Thr Gly His Ile Tyr Leu Lys Asp Ile Ile Thr Asn Val Lys Glu Glu 
865                 870                 875                 880 


Arg Asn Asn Asn Ile Leu Asn Gln Ile Lys Ser Met Gln Leu Pro Val 
                885                 890                 895     


Thr Val Tyr Glu Asn Glu Ser Ser Pro Lys Lys Lys Tyr Leu Arg Thr 
            900                 905                 910         


Ile Tyr Ile Glu Glu Asn Gly Thr Lys Leu Leu Lys Gln Gly Asn Phe 
        915                 920                 925             


Lys Ala Leu Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Val 
    930                 935                 940                 


Lys Thr Ser Ser Glu Ala Glu Ser Lys Arg Asn Pro Ile Ser Lys Leu 
945                 950                 955                 960 


Arg Val Glu His Glu Leu Arg Glu Tyr Gln Lys Ala Arg Ile Asp Ile 
                965                 970                 975     


Ile Lys Asp Met Leu Ala Leu Glu Lys Thr Leu Ile Asp Asn Tyr Asp 
            980                 985                 990         


Ser Leu Asp Thr Asp Asn Phe His  Asn Met Leu Thr Gly  Trp Leu Glu 
        995                 1000                 1005             


Leu Lys  Gly Glu Ala Ile Lys  Thr Lys Phe Asn Asn  Asp Val Lys 
    1010                 1015                 1020             


Leu Leu  Thr Ala Val Arg Asn  Ala Phe Ser His Asn  Gln Tyr Pro 
    1025                 1030                 1035             


Met Tyr  Asp Glu Asn Leu Phe  Ile Asn Ile Glu Arg  Phe Ser Leu 
    1040                 1045                 1050             


Ser Ser  Ser Arg Ile Leu Glu  Ser Lys Gly Leu Gly  Ile Ala Val 
    1055                 1060                 1065             


Lys Leu  Lys Glu Glu Val Ser  Asn Ala Ile Glu Lys  Ile Lys Asn 
    1070                 1075                 1080             


Glu Glu  Asp Ala Lys Lys Glu  Thr 
    1085                 1090     


<210>  2479
<211>  1148
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2479

Met Asn Ser Asn Phe Lys Ala Ser Gly Arg Pro Asn Gly Arg Ser Asn 
1               5                   10                  15      


Gly Phe Arg Gly Ala Gly Pro Val Lys Lys Arg Glu Tyr Leu Thr Gly 
            20                  25                  30          


Asp Phe Ala Arg Asp Met Lys Ser Leu Arg Ile Lys Gly Pro Val Arg 
        35                  40                  45              


Asn Pro Gln Thr Arg Lys Glu Ile Tyr Val Asp Glu Thr Pro Gln Phe 
    50                  55                  60                  


Ile Thr Tyr Leu Thr Leu Ala Leu Gln Asn Ile Ser Glu Ile Ile Gly 
65                  70                  75                  80  


Lys Gly Lys Asp Leu Ser Asn Phe Ser Asp Glu Ser Ser Val Lys Thr 
                85                  90                  95      


Ala Leu Glu Glu Ser Gly Arg Leu Phe Glu Val Ala Ser Phe Leu Trp 
            100                 105                 110         


Met Tyr Arg Val Glu Glu Pro Gly Arg Asp Tyr Asp Arg Ile Lys Lys 
        115                 120                 125             


Gly Glu Tyr Ala Asp Arg Ala Lys Glu Ile Val Val Ala Leu Trp Lys 
    130                 135                 140                 


Leu Arg Asn Met Phe Val His Pro Tyr Glu Lys Asn Ala Ala Lys Ala 
145                 150                 155                 160 


Leu Ile Val Ser Pro Glu Phe Tyr Arg Phe Ile Glu Gly Glu Leu Tyr 
                165                 170                 175     


Ser Glu Ala Arg Glu His Ala Leu Gly Pro Gly Arg Lys Ser Glu Lys 
            180                 185                 190         


Thr Phe Lys Leu Lys Leu Phe Asn Pro His Asp Asp Ala Arg Ala Thr 
        195                 200                 205             


Phe Glu Phe Thr Arg Lys Gly Leu Ile Phe Leu Thr Cys Leu Ala Leu 
    210                 215                 220                 


Tyr Arg His Asp Ala Ser Glu Phe Ile Gln Gln Phe Pro Asp Leu Gln 
225                 230                 235                 240 


Leu Pro Pro Arg Glu Trp Gln Val Glu Gln Gly Tyr Arg Ala Lys Pro 
                245                 250                 255     


Ser Glu Leu Glu Leu Val Glu Leu Arg Lys Lys Gly Gly Ala Val Lys 
            260                 265                 270         


Ser Ile Leu Asp Ala Phe Thr Trp Tyr Ser Met Arg Ala Ser Arg Thr 
        275                 280                 285             


Asp Ile Asp Val Val Asn Ser Asp Tyr Leu Asn Phe Ala Asn Ile Leu 
    290                 295                 300                 


Leu Tyr Leu Asn Lys Val Pro Ser Ala Ala Tyr Asn Tyr Leu Ser Leu 
305                 310                 315                 320 


Asp Glu Glu Ala Arg Arg Leu Ala Glu Lys Ala Ala Ala Ser Gln Glu 
                325                 330                 335     


Ser Glu Glu Asn Lys Arg Phe Arg Tyr Leu Leu Gln Glu Arg Lys Lys 
            340                 345                 350         


Asp Arg Phe Leu Thr Leu Ala Leu Ala Tyr Leu Glu Asp Phe His Arg 
        355                 360                 365             


Leu Asp Cys Ile Ser Phe Lys Arg Leu Asp Ile Thr Val Arg Pro Asp 
    370                 375                 380                 


Arg Lys Arg Tyr Met Phe Gly Pro Ile Pro Glu Gly Thr Val Asn Glu 
385                 390                 395                 400 


Arg Gly Glu Pro Leu Ser Asp Ala Asn Gly Met Asp Arg His Tyr Ala 
                405                 410                 415     


Ile Gln Asn Gly Ser Ala Gln Phe Glu Phe Val Pro Glu Gln His Tyr 
            420                 425                 430         


Gly Pro Ile Gln Leu Lys His Leu Arg Gly Ala Val Ser Glu Gly Glu 
        435                 440                 445             


Ile Met Arg Leu Leu Leu Val Met Phe Asp Asn Gly Ile Arg Arg Lys 
    450                 455                 460                 


Asn Pro Asn Asp Val Ile Lys Glu Tyr Leu Thr Ala Tyr His Arg Ile 
465                 470                 475                 480 


Leu Glu Arg Met Leu Asn Ala Gly Asp Thr Ser Ala Phe Thr Phe Asp 
                485                 490                 495     


Asp Pro Gln Tyr Arg Ala Asp Phe Lys Thr Val Ser Gly Asn Gly Asp 
            500                 505                 510         


Asp Val Phe Thr Lys Asp Arg Phe Val Gly Glu Met Lys Pro Phe Phe 
        515                 520                 525             


Ser Glu Asn Val Thr Arg Tyr Phe Val Gly Asn Glu Leu Arg Pro Ser 
    530                 535                 540                 


Pro Glu Ala Leu Gln Lys Lys Leu Val Lys Arg Phe Glu Ala Met Gln 
545                 550                 555                 560 


Gly Arg Ala Glu Asp Phe Leu Leu Lys Met Asp Arg Leu Thr Asp Trp 
                565                 570                 575     


Arg Lys Leu Asp Met Glu Ala Arg Lys Asp Lys Gly Phe Pro Val Cys 
            580                 585                 590         


Ala Ile Gly Glu Leu Lys Tyr Pro Pro Arg Thr Cys Lys Val Asn Asp 
        595                 600                 605             


Ala Gln Leu Val Lys Trp Val Leu Arg Tyr Ile Asn Leu Phe Leu Ala 
    610                 615                 620                 


Lys Glu Glu Lys Phe Arg Gln Leu Pro Arg Gly Leu Arg His Arg Gly 
625                 630                 635                 640 


Val Arg Asp Phe Glu Phe Gln Leu Leu His Thr Asp Ile Gly Arg Phe 
                645                 650                 655     


Gly Val Asn Pro Asp Ala Leu Trp Arg Thr Leu Glu Lys Arg Ser Ser 
            660                 665                 670         


Ile Asn Gly Glu Gly Gly Ala Leu Glu Met Leu Lys Asp Arg Glu Arg 
        675                 680                 685             


Lys Leu Phe Arg Ser Glu Gln Asp Arg Cys Arg Asp Lys Arg Asp Arg 
    690                 695                 700                 


Asn Gly Arg Pro Leu Arg Val Gly His Thr Leu Thr Met Leu Ala Thr 
705                 710                 715                 720 


Ala Ala Ala Glu Leu Tyr Arg Glu Ile Ser Glu Ser Phe Arg Ser Glu 
                725                 730                 735     


Tyr Ser Val Pro Leu Ser Asp Glu Asp Lys Asp Leu Leu Pro Tyr Val 
            740                 745                 750         


Cys Pro Thr Tyr Gly Val Arg Ala Gly Leu Pro Leu Asp Gln Lys Ser 
        755                 760                 765             


Leu Val Lys Thr Val Leu Gly Ile Asp Leu Asp Thr Trp Ser Arg Ala 
    770                 775                 780                 


Tyr Asp Tyr Ala Thr Gly Arg Asn Phe Glu Asn Arg Gln Leu Ala Asp 
785                 790                 795                 800 


Ala Arg Asp Leu Ile Val Thr Gln Val Pro Met Pro Asn Ala Phe Ala 
                805                 810                 815     


Ile Arg Cys Val Lys Pro Gly Glu Asn Gly Glu Pro Phe Lys Phe Asn 
            820                 825                 830         


Pro Glu Phe Arg Ala Phe Met Pro Tyr Glu Arg Gly Lys Met Ser Leu 
        835                 840                 845             


Arg Arg Tyr Tyr Asp Ala Ala Pro Leu Ile Val Ala Val Lys Arg Phe 
    850                 855                 860                 


Asp Glu Gln Ser Ser Leu Gly Met Gly Gly His Lys Arg Ala Asn Ala 
865                 870                 875                 880 


Glu Ile Arg Cys Ser Gly Thr Glu Gly Ile Glu Thr Arg Glu Trp Thr 
                885                 890                 895     


Asp Asp Gly Asp Ile Gly Ser Gly Lys Gly Pro Pro Arg Ser Arg Pro 
            900                 905                 910         


Ser Phe Ala Arg Gly Asp Val Asn Lys Ala Ile Gln Ala Ile Gln Leu 
        915                 920                 925             


Ala Glu Arg Gln Asp Lys Val Leu Leu Ala Cys Ala Lys Ala Tyr Trp 
    930                 935                 940                 


Asp Arg Tyr Met Gly Glu Glu Val Thr Ala Thr Gln Asn Glu Thr Gly 
945                 950                 955                 960 


Lys Lys Asp Gln Gln Lys Lys Asn Lys Ile Lys Asn Phe His Leu Ser 
                965                 970                 975     


Glu Ala Ala Asp Ile Gly Glu Phe Phe Ser Leu Pro Met Glu Asp Thr 
            980                 985                 990         


Val Asn Gly Val Lys Ile Arg Met  Met Pro Asn Asp Phe  Ala Arg Pro 
        995                 1000                 1005             


Ala Tyr  Gly Val Val Thr Thr  His Val Lys Glu Leu  Val Glu Asp 
    1010                 1015                 1020             


Ala Lys  Pro Leu Pro Gly Thr  Asp Gly Val Tyr Ser  Phe Tyr Asp 
    1025                 1030                 1035             


Leu Trp  Leu Ala Leu Arg Asn  Leu Gln His Glu Glu  Asn Arg Ile 
    1040                 1045                 1050             


Arg Leu  Asp Phe Leu Pro Ala  Ala Val Lys Phe Asn  Ala Cys Val 
    1055                 1060                 1065             


Asn Ile  Pro Pro Asp Leu Glu  Ser Leu Pro Asn Asp  Asp Pro Glu 
    1070                 1075                 1080             


Lys Ala  Pro Arg Ile Leu Ser  His Cys Asn Lys Ala  Leu Arg Ile 
    1085                 1090                 1095             


Arg Gly  Asn Val Lys Pro Leu  Ser Glu Glu Glu Tyr  Leu Leu Leu 
    1100                 1105                 1110             


Ala Arg  Phe Glu Pro Arg Leu  Arg His Pro Ala Ile  Lys Gly Leu 
    1115                 1120                 1125             


Asp Leu  Ile His Phe Asp Thr  Asp Ala Val Arg Ala  Ile Tyr Lys 
    1130                 1135                 1140             


Arg Phe  Gly Phe Met 
    1145             


<210>  2480
<211>  1088
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2480

Met Glu Lys Ile Asp Phe Lys Leu Lys Glu Thr Asp Tyr Thr Arg Leu 
1               5                   10                  15      


Tyr Ser Glu Gln Thr Asp Cys Lys Arg His Val Val Gly Ala Tyr Ala 
            20                  25                  30          


Asn Leu Ala Leu His Asn Met Thr Thr Val Val Asn Ser Ile Arg Gln 
        35                  40                  45              


Ala Val Gly Leu Asp Thr Ile Thr Asp Asp Thr Ile Lys Asp Ala Phe 
    50                  55                  60                  


Ser Arg Asp Ser Phe Lys Gly Leu Asp Ala Gly Asn Gln Leu Lys Leu 
65                  70                  75                  80  


Gln Asn Lys Leu Phe Arg His Phe Pro Phe Leu Arg Arg Met Lys Leu 
                85                  90                  95      


Glu Gln His Gly Thr Leu Asp Tyr Ser Glu Val Ile Asn Asp Phe Ile 
            100                 105                 110         


Lys Leu Met Ser Ile Ile Arg Asp Asp Phe Ser His Tyr Cys Pro Tyr 
        115                 120                 125             


Ser Asp Glu Ser Gln Gln Thr Glu Asn Ser Leu Ile Lys Lys Asn Ala 
    130                 135                 140                 


Ser Glu Lys Leu Lys Glu Ile Phe Thr Asn Ser Val Ser Gln Tyr Leu 
145                 150                 155                 160 


His Thr Ala Glu Glu Asn Glu Val Arg Asp Ser Val Gln Asn Ser Lys 
                165                 170                 175     


Thr Gln Gln Asp Asn Lys Val Thr Ile Thr Glu Asn Ser Ile Asp Met 
            180                 185                 190         


Arg Asp Pro Ala Ser Lys Asp Gly Leu Thr Asp Ala Gly Ile Val Phe 
        195                 200                 205             


Phe Leu Cys Cys Phe Leu Glu Lys His Thr Ala Phe Glu Phe Leu Glu 
    210                 215                 220                 


Glu Ile Lys Phe Thr Glu Gly Leu Asn Pro Ala Asn Ala Leu Tyr Val 
225                 230                 235                 240 


Lys Glu Ile Leu Cys Met Asn Arg Ile Arg Met Thr Arg Ser Gln Ile 
                245                 250                 255     


Asp Ser Gln Met Ser Asp Thr Ala Leu Ala Leu Asp Met Met Asn Glu 
            260                 265                 270         


Leu Arg Lys Cys Pro Lys Pro Leu Tyr Asp Val Leu Asp Pro Ala Ser 
        275                 280                 285             


Arg Asn Tyr Phe Lys Asp Asp Ala Asn Leu Gln Trp Glu Glu Asp Asn 
    290                 295                 300                 


Pro Thr Gln Thr Asp Ser Gln Ser Pro Asp Ser His Asn Ile Thr Asp 
305                 310                 315                 320 


Leu Arg Ala Lys Ser Val Pro Arg Ser Thr Phe Val Arg Trp Gln Asn 
                325                 330                 335     


Arg Phe Pro Glu Met Ala Leu Cys Phe Ile Asp Leu Lys Gly Leu Phe 
            340                 345                 350         


Lys Thr Thr Arg Phe Gln Leu Arg Leu Gly Asn Tyr Arg Tyr Arg Phe 
        355                 360                 365             


Tyr Thr His Thr Ala Gln Gln Ser Leu Asp Gly Arg Glu Arg Leu Arg 
    370                 375                 380                 


Ile Leu Gln Lys Glu Leu His Gly Phe Gly Arg Ile Asn Glu Ile Glu 
385                 390                 395                 400 


Gln Thr Ile Lys Lys Glu Trp Gly Gln Tyr Ile Glu Lys Asn Thr Thr 
                405                 410                 415     


Asp Pro Lys Pro Lys Asp Gln Pro Asp Arg Thr Pro Tyr Ile Thr His 
            420                 425                 430         


Gln Arg Pro Gln Tyr Asn Ile Asp Pro Val Ser His Ser Ile Gly Leu 
        435                 440                 445             


Arg Trp Asp Phe Pro Asn Lys Lys Thr Lys Tyr Tyr Ile Pro Glu Ile 
    450                 455                 460                 


Gln Pro Gln Gln Lys Cys Pro Ser Glu Asn Leu Ala Pro Gln Cys Tyr 
465                 470                 475                 480 


Leu Asn Thr Asp Glu Leu Pro Ala Leu Leu Phe Tyr Gln Tyr Ile Lys 
                485                 490                 495     


Asn Thr Tyr Ser Pro Asn Lys Gly Ser Ser Ala Glu Asn Ile Ile Arg 
            500                 505                 510         


Lys Cys Tyr Ile Asn Leu His Thr Leu Phe Ser Gln Leu Ala Lys Asn 
        515                 520                 525             


Glu Lys Ile Ser Ile Asn Glu Leu Asp Lys Trp Glu Leu Arg Pro Ser 
    530                 535                 540                 


Asp Ile Pro Ala Lys Ile Arg Lys Leu Met Glu Gly His Glu Arg Ser 
545                 550                 555                 560 


Glu Lys Glu Ile Arg Asp Ser Leu Arg Arg Ser Ile Glu His Gln Leu 
                565                 570                 575     


Ala Leu Ile Asp Lys Thr Thr Tyr Glu Arg Leu Val Lys Tyr Glu Ala 
            580                 585                 590         


Ala Thr Asp Lys Lys Glu Gln Thr Asp Lys Lys Thr Thr Arg Phe Arg 
        595                 600                 605             


Pro Pro Ile Leu Thr Gly Arg Leu Ala Gln Gln Leu Ile Asp Asp Ile 
    610                 615                 620                 


Val Trp Trp Leu Pro Thr Asp Ser Pro Cys Arg Ser Arg Leu Thr Ser 
625                 630                 635                 640 


Glu Lys Tyr Asn Ile Leu Gln Ala Ser Ile Ala Leu Leu Gly Gln Trp 
                645                 650                 655     


Thr Asp Ala Ser Asp Pro Ser Gln Gln Thr Val Thr Ile Asp Asp Leu 
            660                 665                 670         


Arg Gln Met Met Glu Lys Ile Gly Leu Leu Gly Pro Asp Gly His Pro 
        675                 680                 685             


Phe Leu Ser Gln Val Phe Lys Gln Pro Ile Gln Ser Ala Gly Phe Phe 
    690                 695                 700                 


Tyr His Asn Tyr Leu Tyr Ala Glu Gln Asp His Ile Glu Thr Leu Trp 
705                 710                 715                 720 


Gln Asp Phe Asp His Asn Leu Asp Gln Leu Ile Ser Gln Ala His Ala 
                725                 730                 735     


Lys Leu Pro Phe Val His Ile Asp Arg Pro Lys Trp Asn Val Asp Lys 
            740                 745                 750         


Ser Asn Asn Leu Ser Gln Leu Ala Gln Glu Tyr Leu Thr His Pro Leu 
        755                 760                 765             


Gln Leu Pro Leu Gly Leu Phe Ala Gln Pro Ile Ala Gln Leu Leu Arg 
    770                 775                 780                 


Asp Ile Ala Glu Gly Glu Ala Thr Glu Thr Trp Lys Gln Leu Thr Ala 
785                 790                 795                 800 


Glu Ile Asp Arg Leu Thr Gln Lys Gly Gln Pro Ser Thr Leu Lys Leu 
                805                 810                 815     


Ile Glu Leu Tyr His Lys Asn Ile Glu Glu Asp Asp Phe Gln Asn Phe 
            820                 825                 830         


Tyr Asn Ser Ser Pro Asn Ala Gly Phe Gln His His Tyr Glu Leu Phe 
        835                 840                 845             


Lys Lys Ile Tyr Lys Glu Lys Gly Arg Ser Val Glu Glu Val Phe Asn 
    850                 855                 860                 


Leu Leu Arg Arg Lys Ser Asn Pro Pro Gln Ser Lys Ser Gln Leu Asp 
865                 870                 875                 880 


Cys Asp Ile His Glu Tyr Val Glu Lys His Arg Lys Asp Lys Ser Lys 
                885                 890                 895     


Glu Trp Ala Glu Asp Gln Thr Thr Leu Met Arg Lys Gln Ala Lys Gln 
            900                 905                 910         


Val Glu Gln Thr Glu His Ala Ile Arg Arg Cys Gln Ile Glu Asp Ile 
        915                 920                 925             


Val Met Leu Tyr Ala Ala Arg Val Met Leu Tyr Ala Ala Arg Asp Ile 
    930                 935                 940                 


Leu Ser Ala Lys Asn Asn Arg Thr Pro Asn Gly Thr Asp Thr His Gln 
945                 950                 955                 960 


Pro Gln Lys Phe Lys Leu Lys His Val Gln Asn Asp Asp Gly Leu Leu 
                965                 970                 975     


Glu Arg Thr Ile Asp Phe Asn Trp Val Val Asp Ile Glu Gly Gln Gln 
            980                 985                 990         


Lys Thr Ile Arg Gln Gln Asn Met  Lys Met Lys Asp Tyr  Gly Lys Phe 
        995                 1000                 1005             


Tyr Lys  Phe Ala Ser Asp Gly  Glu Arg Leu Glu Ser  Leu Leu Ala 
    1010                 1015                 1020             


His Leu  Gly Gly Asn Glu Phe  Gln Arg Ala Asp Ile  Glu Ala Glu 
    1025                 1030                 1035             


Tyr Ala  Gln Tyr Asp Asp Cys  Arg Ser Gln Val Phe  Arg Tyr Val 
    1040                 1045                 1050             


Tyr Met  Leu Glu Ser Lys Ala  Tyr Gln Leu Leu Ala  Met Gln Lys 
    1055                 1060                 1065             


Asp Asn  Pro Ile Asp Leu Leu  Asp Asp Lys Asn Ser  Thr Arg Asp 
    1070                 1075                 1080             


Glu Phe  Trp Phe Val 
    1085             


<210>  2481
<211>  1095
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2481

Met Glu Asn Lys Arg Thr Leu Lys Asp His Pro Gln Tyr Phe Gly Ala 
1               5                   10                  15      


Phe Leu Asn Met Ala Arg His Asn Val Phe Val Ile Asn Asn His Leu 
            20                  25                  30          


Ala Glu Arg Phe Lys Leu Ser Pro Leu Pro Glu Asp Ser His Ile Pro 
        35                  40                  45              


Thr Ser Phe Leu Thr Arg Pro Ile Lys Glu Arg Pro Asn His Ile Phe 
    50                  55                  60                  


Ser His Leu Ile Arg Phe Ile Pro Ile Ala Lys Val Phe Asp Pro Glu 
65                  70                  75                  80  


Gln Leu Pro Lys Glu Glu Arg Thr Glu Glu Lys Ser Lys Thr Gly Lys 
                85                  90                  95      


Asp Phe Asn Lys Leu Lys Glu Thr Phe Lys Ile Cys Phe Ser Lys Leu 
            100                 105                 110         


Asn Asp Phe Arg Asn Asp Tyr Ser His Phe Phe Ser Thr Lys Lys Arg 
        115                 120                 125             


Thr Glu Arg Lys Leu Met Val Asp Lys Leu Leu Ala Asp Phe Leu Thr 
    130                 135                 140                 


Thr Asn Tyr Ser Arg Ala Ile Gln Tyr Ser Ile Lys Arg Phe Thr Gly 
145                 150                 155                 160 


Val Phe Lys Asp Glu His Phe Glu Leu Ala Arg Lys Asn Ile Ile Leu 
                165                 170                 175     


Val Asp Asn Glu Asn Lys Ile Thr Glu Asp Gly Leu Val Phe Phe Thr 
            180                 185                 190         


Cys Leu Phe Leu Asp Arg Glu Asn Ala Phe Gln Phe Ile Asn Lys Ile 
        195                 200                 205             


Ile Gly Phe Lys Gly Thr His Thr Leu Glu Phe Lys Ala Thr Arg Glu 
    210                 215                 220                 


Val Phe Cys Ala Phe Cys Val Asn Leu Pro His Asp Arg Phe Ile Ser 
225                 230                 235                 240 


Asp Asp Pro Glu Gln Ala Phe Ile Leu Asp Met Leu Asn Glu Leu Asn 
                245                 250                 255     


Arg Cys Pro Ser Glu Leu Phe Asn Ser Leu Thr Glu Glu Gly Lys Lys 
            260                 265                 270         


Pro Phe Gln Pro Thr Leu Asp Ser Lys Gln Ile Thr Asn Ile Glu Asp 
        275                 280                 285             


Asn Asn Ala Val Ala Lys Glu Leu Pro Asp Glu Asp Phe Tyr Glu Tyr 
    290                 295                 300                 


Met Gln Ser Ile Thr Lys Arg Ile Arg His Glu Asp Arg Phe Pro Tyr 
305                 310                 315                 320 


Leu Ala Leu Lys Tyr Leu Asp Thr Thr Lys Ala Phe Asn Lys Ile Arg 
                325                 330                 335     


Phe Gln Ile Asp Leu Gly Lys Phe Gln Ile Asp Glu Tyr Lys Lys Gln 
            340                 345                 350         


Phe Asn Asn Ala Glu Glu Asp Arg Met Ile Ile Glu Asn Ala Lys Ala 
        355                 360                 365             


Phe Gly Arg Leu Asp Glu Phe Thr Ser Ile Glu Lys Thr Lys Asp Glu 
    370                 375                 380                 


Leu Glu Lys Val Ile Gly Lys Met Ile Asn Lys Asp Gly Phe Lys Asn 
385                 390                 395                 400 


Val Asp Ser Lys Gln Phe Ala Phe Glu Gln Phe Ser Pro Arg Tyr Asn 
                405                 410                 415     


Tyr Asp Lys Glu Lys Asn Lys Ile Gly Phe Gln Phe Phe Pro Asn Gly 
            420                 425                 430         


Ile Gly Val Pro Ile Tyr Pro Lys Leu Lys Lys Ser Glu Asn Glu Lys 
        435                 440                 445             


Ser Asn Val Lys Tyr Asn Leu Phe Gln Asn Asn Pro His Ala Phe Leu 
    450                 455                 460                 


Ser Ile His Glu Leu Pro Lys Val Val Leu Leu Glu Leu Leu Glu Lys 
465                 470                 475                 480 


Gly Lys Val Glu Thr Ile Ile Glu Glu Phe Ile Asn Ser Asn Asn Thr 
                485                 490                 495     


Lys Ile Leu Asn Lys Asp Phe Ile Glu Glu Ile Lys Asn Lys Leu Lys 
            500                 505                 510         


Phe Glu Lys Pro Phe Tyr Lys Lys Phe Gln Lys Lys Asn Leu His Ala 
        515                 520                 525             


Tyr Asp Asn Pro Ser Ile Glu Asp Tyr Thr Glu Arg Lys Asn Lys Leu 
    530                 535                 540                 


Asn Glu Ile Leu Asn Asp Leu Lys Thr Arg Lys Glu Gln Leu Asn Glu 
545                 550                 555                 560 


Leu Leu Ser His Tyr Asn Leu Asn His Thr Gln Ile Pro Thr Arg Ile 
                565                 570                 575     


Val Asn Tyr Trp Leu Asp Ile Lys Glu Ile Lys Glu Glu Thr Ala Ile 
            580                 585                 590         


Val Asn Arg Ile Lys Ala Phe Arg Ser Glu Cys Ala Glu Arg Leu Lys 
        595                 600                 605             


Asp Lys Lys Lys Gly Lys Ala Pro Lys Ile Gly Val Met Ala Thr Phe 
    610                 615                 620                 


Leu Ala Lys Asp Ile Val Asn Met Val Ile Asp Glu Asn Ile Lys Lys 
625                 630                 635                 640 


Lys Ile Thr Pro Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu 
                645                 650                 655     


Phe Ala Gly Asp Glu Asn Lys Gln Leu Phe Ile Thr Ile Cys Asn Glu 
            660                 665                 670         


Leu Asn Leu Phe Asn Lys Glu Thr Gly His Pro Phe Leu Gln His Leu 
        675                 680                 685             


Asn Ile Lys Glu Gln Ile His Tyr Thr Pro Asp Phe Tyr Gln Lys Tyr 
    690                 695                 700                 


Leu Glu Lys Lys Gln Asn Trp Ile Glu Asp Val Phe Tyr Lys Leu Glu 
705                 710                 715                 720 


Trp Asn Glu Lys Ala Lys Lys Lys Leu Thr Ile Val Ala Leu Pro Glu 
                725                 730                 735     


Asn Leu Thr Leu Pro Phe Ser Ile Arg Asn Leu Asp Arg Thr Lys Ser 
            740                 745                 750         


Asp Phe Asp Ser Trp Leu Asn Asn Leu Ile Asn Gly Lys Lys Glu Lys 
        755                 760                 765             


Asp Asn Pro Lys Pro Leu Asp Leu Pro Thr Asp Leu Phe Asp Asn Ala 
    770                 775                 780                 


Leu Val Glu Val Leu Thr Asn Lys Thr Gly Ile Glu Arg Asn Pro Lys 
785                 790                 795                 800 


His Asn Tyr Ser Tyr Leu Leu Thr Gln Trp Leu Lys Asp Thr Gln Pro 
                805                 810                 815     


Phe Tyr Asn Phe Glu Arg Glu Tyr Glu Ile Tyr Lys Asp Lys Val Tyr 
            820                 825                 830         


Lys Glu Thr Val Lys Phe Lys Leu Gly Ser Lys Pro Thr Phe Lys Asp 
        835                 840                 845             


Tyr Phe Leu Ser Ser Ile Lys Thr Val Leu Gln Lys Leu Asn Ile Glu 
    850                 855                 860                 


Arg Lys Ile Glu Arg Lys Pro Leu Leu Asn Glu Asn Asp Ile Leu Arg 
865                 870                 875                 880 


Val Phe Asn His Ala Ile Thr Glu Asn Glu Lys Leu Ile Arg Phe Tyr 
                885                 890                 895     


Gln Thr Lys Asp Arg Val Met Leu Leu Met Leu Lys Glu Leu Met Lys 
            900                 905                 910         


Ser Asp Arg Asp Leu Asn Ile Thr Leu His Asn Ile Glu Ala Ala Leu 
        915                 920                 925             


Asn Glu Thr Val Glu Ile Glu Gln Lys Val Lys Gly Leu Leu Ser Tyr 
    930                 935                 940                 


Asp Ala Gln Gly Asn Leu Ile Ser Gly Glu Asp Lys Lys Ile Pro Ile 
945                 950                 955                 960 


Glu Lys Thr Ile Thr Asp Lys Arg Lys Arg Lys Asp Phe Ser Val Phe 
                965                 970                 975     


Lys Lys Phe Ile Ser Asp Arg Arg Leu Pro Glu Leu Phe Gln Tyr Phe 
            980                 985                 990         


Lys Glu Asn Glu Ile Pro Tyr Gln  Gln Leu Lys Asp Glu  Leu Asp Glu 
        995                 1000                 1005             


Tyr Asn  Lys Glu Lys Glu Lys  Val Phe Asp Glu Thr  Phe Lys Leu 
    1010                 1015                 1020             


Glu Thr  Ala Ile Ile Glu Lys  Ala Glu Asn Glu Ile  Lys Glu Leu 
    1025                 1030                 1035             


Phe Arg  Asp Lys Lys Gly Asn  Lys Ile Glu Gly Asn  Ile Gln Phe 
    1040                 1045                 1050             


Glu Pro  Tyr Leu Lys Trp Leu  Lys Glu Lys Asn Phe  Ile Gly Asp 
    1055                 1060                 1065             


Thr Glu  Phe Lys Ile Leu Lys  Val Ile Arg Asn Ala  Phe Ser His 
    1070                 1075                 1080             


Asn Gln  Phe Pro Pro Lys Ile  Val Met Asp Lys Asn  
    1085                 1090                 1095 


<210>  2482
<211>  940
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2482

Met Glu Glu Phe Thr Phe Lys Leu Lys Glu Thr Asp Tyr Thr Arg Leu 
1               5                   10                  15      


Tyr Ser Glu Gln Thr Asp Cys Lys Arg His Val Val Gly Ala Tyr Ala 
            20                  25                  30          


Asn Leu Ala Leu His Asn Met Thr Thr Val Val Asn Ser Ile Arg Gln 
        35                  40                  45              


Ala Val Gly Leu Asp Thr Ile Thr Asp Asp Thr Ile Lys Asp Ala Phe 
    50                  55                  60                  


Ser Gly Glu Ser Phe Lys Gly Leu Asp Ala Gly Asn Gln Leu Lys Leu 
65                  70                  75                  80  


Gln Asn Lys Leu Phe Arg His Phe Pro Phe Leu Arg Arg Met Lys Leu 
                85                  90                  95      


Glu Gln His Gly Thr Leu Glu Tyr Ser Lys Val Ile Asn Val Met Lys 
            100                 105                 110         


Asp Phe Ile Lys Leu Met Ser Ile Ile Arg Asp Asp Phe Ser His Tyr 
        115                 120                 125             


Cys Pro Tyr Ser Asn Lys Ser Gln Gln Thr Glu Asn Ser Ser Ile Lys 
    130                 135                 140                 


Lys Asn Ala Ser Lys Lys Leu Asp Glu Ile Phe Thr Asn Ser Val Ser 
145                 150                 155                 160 


Gln Asn Leu His Thr Ala Glu Glu Asn Glu Val Arg Asp Ser Val Leu 
                165                 170                 175     


Asn Ser Lys Thr Gln Gln Asp Lys Lys Ala Ser Thr Pro Leu Val Ser 
            180                 185                 190         


Ile Pro Met Arg Asp Asn Ala Gly Leu Thr Asp Ala Gly Ile Val Phe 
        195                 200                 205             


Phe Leu Cys Cys Phe Leu Glu Lys His Ser Ala Phe Glu Phe Leu Glu 
    210                 215                 220                 


Glu Ile Glu Phe Thr Glu Gly Leu Asn Pro Ala Asn Ala Leu Tyr Val 
225                 230                 235                 240 


Lys Glu Ile Leu Cys Met Asn Arg Ile Arg Met Thr Arg Ser Gln Ile 
                245                 250                 255     


Asp Ser Gln Met Ser Asp Thr Ala Leu Ala Leu Asp Met Met Asn Glu 
            260                 265                 270         


Leu Arg Lys Cys Pro Lys Pro Leu Tyr Asp Val Leu Asp Pro Ser Ser 
        275                 280                 285             


Arg Asn Tyr Phe Lys Asp Asp Ala Asn Leu Gln Trp Glu Glu Asp Asn 
    290                 295                 300                 


Pro Thr Gln Thr Asp Ser Gln Ser Pro Asp Ser His Asn Ile Thr Asp 
305                 310                 315                 320 


Leu Arg Ala Lys Ser Val Pro Arg Ser Thr Phe Val Arg Trp Gln Asn 
                325                 330                 335     


Arg Phe Pro Glu Met Ala Leu Cys Phe Ile Asp Leu Lys Gly Leu Phe 
            340                 345                 350         


Gln Thr Thr Arg Phe Gln Leu Arg Leu Gly Asn Tyr Arg Tyr Arg Phe 
        355                 360                 365             


Tyr Thr His Thr Ala Gln Gln Ser Leu Asp Gly Arg Glu Arg Leu Arg 
    370                 375                 380                 


Ile Leu Gln Lys Glu Leu His Gly Phe Gly Arg Ile Asn Glu Ile Glu 
385                 390                 395                 400 


Gln Thr Ile Lys Lys Glu Trp Gly Gln Tyr Ile Glu Lys Asn Thr Thr 
                405                 410                 415     


Asp Pro Lys Pro Lys Asp Gln Pro Asp Arg Thr Pro Tyr Ile Thr His 
            420                 425                 430         


Gln Arg Pro Gln Tyr Asn Ile Asp Pro Val Ser His Ser Ile Gly Leu 
        435                 440                 445             


Cys Trp Asp Phe Pro Asp Glu Lys Thr Tyr Tyr Ile Pro Glu Phe Pro 
    450                 455                 460                 


Pro Lys Lys Gln Asp Asp His Thr Gln Gln Gln Lys Cys Pro Ser Glu 
465                 470                 475                 480 


Asn Leu Ala Pro Gln Cys Tyr Leu Asn Thr Asp Glu Leu Pro Ala Leu 
                485                 490                 495     


Leu Phe Tyr Gln Tyr Ile Lys Asp Lys Tyr Ser Leu Asn Glu Val Ser 
            500                 505                 510         


Ser Ala Glu Asn Ile Ile Gln Lys Cys Tyr Ile Asn Leu His Thr Leu 
        515                 520                 525             


Phe Ser Gln Leu Ala Lys Asn Glu Lys Ile Ser Ile Asn Glu Leu Asp 
    530                 535                 540                 


Lys Trp Glu Leu Arg Pro Ser Asp Ile Pro Ala Lys Ile Arg Lys Leu 
545                 550                 555                 560 


Met Glu Gly His Glu Arg Asn Glu Lys Glu Ile Arg Asp Ser Leu Arg 
                565                 570                 575     


Arg Ser Ile Glu His Gln Leu Ala Leu Ile Asp Lys Thr Thr Tyr Glu 
            580                 585                 590         


Arg Leu Val Lys Tyr Glu Ala Ala Thr Asp Lys Lys Glu Gln Thr Asp 
        595                 600                 605             


Gln Lys Thr Thr Arg Phe Arg Pro Pro Ile Leu Thr Gly Arg Leu Ala 
    610                 615                 620                 


Gln Gln Leu Ile Asp Asp Ile Val Trp Trp Leu Pro Thr Asp Ser Pro 
625                 630                 635                 640 


Cys Arg Ser Arg Leu Thr Ser Glu Lys Tyr Asn Ile Leu Gln Ala Ser 
                645                 650                 655     


Ile Ala Leu Leu Gly Gln Arg Thr Asn Pro Ser Asp Pro Ser Gln Gln 
            660                 665                 670         


Thr Val Thr Ile Asp Asp Leu Gln Gln Met Met Glu Arg Ile Gly Leu 
        675                 680                 685             


Leu Gly Pro Asp Gly His Pro Phe Leu Asn Arg Val Phe Lys Gln Pro 
    690                 695                 700                 


Asn Gln Ser Ala Gly Ile Phe Tyr His Asn Tyr Gln Tyr Ala Glu Gln 
705                 710                 715                 720 


Asp His Ile Glu Thr Leu Trp Gln Asp Phe Asp Leu Asn Leu Asp Gln 
                725                 730                 735     


Leu Ile Ser Gln Ala His Ala Lys Leu Pro Phe Val His Ile Asn Arg 
            740                 745                 750         


Pro Lys Trp Asn Val Asp Lys Ser Asn Ser Leu Ser Gln Leu Ala Gln 
        755                 760                 765             


Lys Tyr Leu Thr His Pro Leu Gln Leu Pro Leu Gly Leu Phe Ala Gln 
    770                 775                 780                 


Pro Ile Ala Gln Leu Leu Arg Asp Ile Ala Glu Gly Glu Ala Thr Glu 
785                 790                 795                 800 


Thr Trp Lys Gln Leu Thr Ala Glu Ile Asp Arg Leu Thr Gln Asn Gly 
                805                 810                 815     


Gln Pro Ser Thr Leu Lys Leu Ile Glu Leu Tyr His Lys Asn Ile Glu 
            820                 825                 830         


Glu Asp Asp Phe Gln Asn Phe Tyr Asn Ser Ser Pro Asn Ala Gly Phe 
        835                 840                 845             


Pro His His Tyr Glu Leu Phe Lys Lys Leu Tyr Lys Glu Lys Gly Arg 
    850                 855                 860                 


Ser Val Glu Glu Val Phe Asn Leu Leu Arg Arg Lys Ser Asn Pro Pro 
865                 870                 875                 880 


Gln Ser Lys Ser Gln Leu Asp Cys Asp Ile His Lys Tyr Val Glu Lys 
                885                 890                 895     


His Cys Lys Asp Lys Ser Lys Glu Trp Ala Glu Asp Gln Thr Ala Leu 
            900                 905                 910         


Met Arg Lys Gln Ala Lys Gln Val Glu Gln Thr Glu His Ala Ile Arg 
        915                 920                 925             


Arg Cys Gln Ile Glu Asp Ile Val Met Leu Tyr Ala 
    930                 935                 940 


<210>  2483
<211>  1266
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2483

Met Ala Phe Asp Lys Pro Arg Pro Lys Arg Arg Gln Ala Arg Ser Asp 
1               5                   10                  15      


Phe Tyr Ile Thr Asp Lys Ala Ile Met Gly Gly Tyr Phe Asn Leu Ala 
            20                  25                  30          


Gln Leu Asn Phe Phe Lys Thr Leu Met Glu Ile Phe Thr Lys Ala Gly 
        35                  40                  45              


Ile Asp Val Ser Lys Ile Arg Gln Asp Asn Ser Pro Lys Tyr Leu Met 
    50                  55                  60                  


Ile Leu Ile Lys Lys Leu Thr His Asp Asp Glu Lys Ile Asp Asp Lys 
65                  70                  75                  80  


Lys Trp Ala Asp Ala Leu Asp Leu Ser Asn Glu Cys Leu Leu Lys Leu 
                85                  90                  95      


Gln Gln Leu Leu Tyr Lys His Phe Pro Phe Leu Gly Pro Val Met Gly 
            100                 105                 110         


Gly Glu Ala Ser Tyr Asn Ile Tyr Lys Leu Lys Asp Gly His Pro Glu 
        115                 120                 125             


Val Lys Ile Ala Asn Asn Val Met Arg Gly Val Lys Leu Glu Asp Cys 
    130                 135                 140                 


Leu Ala Val Ile Arg His Phe Ala Leu Cys Leu Asn Asp Cys Arg Asn 
145                 150                 155                 160 


Phe Tyr Thr His Phe Asn Pro Tyr Asn Pro Ile Asp Ala Gln Lys Glu 
                165                 170                 175     


Gln Tyr Leu Ser Gln Asn Lys Val Ala Val Trp Leu Asp Lys Val Lys 
            180                 185                 190         


Asp Ala Ser Arg Arg Ile Ile Lys Gln Asn Asn Gln Leu Thr Ser Gln 
        195                 200                 205             


Asp Met Glu Phe Leu Thr Gly Asp Arg Met Lys Pro Gln Asp Lys Val 
    210                 215                 220                 


Asp Glu Phe Gly Asn Ile Met Thr Asp Lys Lys Gly Tyr Thr Ile Lys 
225                 230                 235                 240 


Glu Tyr Val Glu Tyr Glu Asp Tyr Tyr Phe Arg Ile Arg Gly Lys Arg 
                245                 250                 255     


Tyr Leu Val Asp Ala Ala Gly Ala Lys Leu Val Asp Gln Glu Pro Arg 
            260                 265                 270         


Asn Ala Leu Ser Asp Phe Gly Val Val Phe Leu Cys Thr Leu Phe Leu 
        275                 280                 285             


Glu Ser Asp Gln Ala Arg Arg Met Leu Asp Glu Leu Arg Leu Phe Glu 
    290                 295                 300                 


Thr Gly Pro Tyr Asp Gly Ser Arg Asp Gly Asp Glu Phe Lys Asn Asp 
305                 310                 315                 320 


Ile Leu Arg Glu Ile Leu Leu Phe Tyr Arg Thr Arg Val Pro Arg Gly 
                325                 330                 335     


Lys Arg Leu Asp Pro Met Asp Asp Thr Thr Leu Leu Ala Met Asp Met 
            340                 345                 350         


Leu Asn Glu Leu Arg Lys Cys Pro Met Pro Leu Tyr Asp Val Leu Ser 
        355                 360                 365             


Arg Glu Gly Gln Gly Phe Phe Glu Asp Glu Val Lys Arg Pro Asn Asp 
    370                 375                 380                 


Leu Thr Pro Glu Val Ala Lys Arg Leu Arg Ser Ser Asp Arg Phe Pro 
385                 390                 395                 400 


Tyr Leu Ala Leu Arg Tyr Ile Asp Leu Asn Lys Cys Phe Gly Asn Ile 
                405                 410                 415     


Arg Phe Gln Val Gln Leu Gly Glu Phe Arg Tyr Lys Phe Tyr Asp Lys 
            420                 425                 430         


Thr Thr Ile Asp Gly Glu Gln Val Val Arg Gly Leu Gln Lys Glu Val 
        435                 440                 445             


Asn Ala Tyr Gly Arg Leu Gln Asp Val Glu Arg Tyr Arg Leu Glu Lys 
    450                 455                 460                 


Tyr Ala Asp Met Leu Gln Gln Thr Glu Leu Val Glu Thr Gly Glu Glu 
465                 470                 475                 480 


Asp Ile Thr Ile Ala Asn Phe Ile Pro Asp Thr Pro Gln Ser Ser Pro 
                485                 490                 495     


Tyr Leu Ser Asp Arg Thr Ala Ser Tyr Asn Ile His Asn Asn Arg Ile 
            500                 505                 510         


Gly Leu Leu Trp Asn Met Pro Gly Glu His Glu Val Leu Thr Gly Asp 
        515                 520                 525             


Glu Lys Met Tyr Leu Pro Asp Leu Lys Val Asp Glu Asn Gly Lys Ala 
    530                 535                 540                 


Asp Val Phe Leu Pro Ala Pro Arg Ala Ser Leu Ser Val Arg Asp Leu 
545                 550                 555                 560 


Pro Ala Leu Val Phe Tyr Leu Tyr Leu His Asn Gln Tyr Pro Asp Leu 
                565                 570                 575     


Thr Pro Ala Glu Ala Ile Ile Gln Gln Lys Tyr Asn Ala Leu Val Arg 
            580                 585                 590         


Phe Phe Asp Asp Val Ser Thr Gly His Met Leu Pro Val Asn Gly Ile 
        595                 600                 605             


Glu Glu Leu Glu Lys Ala Ile Asp Gln Tyr Gly His Leu Thr Val Asn 
    610                 615                 620                 


Glu Ile Pro Glu Lys Leu Arg Asp Tyr Leu Ala Gly Ser Ala Arg Ala 
625                 630                 635                 640 


Glu Asn Asp Asp Asp Cys Gly Val Arg Phe Asp Trp Tyr Ala Leu Gly 
                645                 650                 655     


Val Leu Glu Lys Arg Tyr Lys Gln Val Arg Ala Arg Ile Asp Gln Leu 
            660                 665                 670         


Lys Glu Ala Arg Lys Met Val Gly Asp Lys Met Asn Arg Tyr Gly Lys 
        675                 680                 685             


Lys Ser Tyr Ile Asp Val Arg Pro Arg Arg Leu Ala Glu Gln Leu Ala 
    690                 695                 700                 


Gln Ser Ile Val Asp Trp Gln Pro Ser Thr Asp Asn Gly Arg His Lys 
705                 710                 715                 720 


Met Thr Gly Lys Asn Phe Gln Arg Leu Ile Ala Phe Leu Ala Arg Tyr 
                725                 730                 735     


Thr Asp Glu Val Pro Val Gln Glu Ile Lys Asp Leu Met Thr Arg Ala 
            740                 745                 750         


Arg Leu Leu Glu Gly Pro Val Ala His Pro Phe Leu Gln Gln Val Leu 
        755                 760                 765             


Asp Lys Asn Pro Leu Asn Ile Glu Val Leu Tyr Asp Leu Tyr Phe Lys 
    770                 775                 780                 


Glu Glu Lys Arg Tyr Leu Asp Lys Tyr Ile Asp Ile Glu Ile Asn Lys 
785                 790                 795                 800 


Gln Gly Glu Glu Val Tyr Trp Ile Lys Pro Asp Ala Asp Leu Ser Lys 
                805                 810                 815     


Ile Pro Phe Leu Asn Ser Ser Arg Leu Arg Phe His Lys Leu Asp Ser 
            820                 825                 830         


Ala Tyr Tyr Gln Arg Leu Ala Ala Arg Tyr Leu Gln Val Asp Gly Arg 
        835                 840                 845             


Gln Ser Thr Ile Leu Leu Pro Asp Gly Leu Phe Thr Pro His Ile Leu 
    850                 855                 860                 


Ser Val Leu Lys Ser Thr Leu Tyr Gln Glu Asn Arg Asp Leu Gln Asp 
865                 870                 875                 880 


His Leu Gln Asp Gln Glu Leu Asn Arg Asn Ala Ser Tyr Leu Met Ser 
                885                 890                 895     


Val Tyr Leu Glu His Val Leu His Asp Ser Ala Gln Pro Phe Tyr Met 
            900                 905                 910         


Pro Asn Ser Asn Asp Ser Pro Phe Ala Arg Arg Tyr Asp Leu Phe Ala 
        915                 920                 925             


Ile Val Gln Asn Asn Lys Lys Gly Ile Glu Leu Leu Pro Cys Pro Leu 
    930                 935                 940                 


Thr Pro Val Glu Ile Asn Arg Arg Leu Thr Gly Lys Thr Pro Asp Cys 
945                 950                 955                 960 


Arg Ala Lys Leu Ile Glu Arg Asp Ile Leu Ala Leu Leu Glu Asp Met 
                965                 970                 975     


Ala Arg Lys Thr Glu Gln Arg Ile His Lys Leu Pro Gln Gly Leu Tyr 
            980                 985                 990         


Arg Lys Lys Lys Asn Glu Ala Gln  Glu Glu Arg Ile Lys  Leu Gln Gln 
        995                 1000                 1005             


Arg Met  Arg His Lys Ile Ala  Asn Val Lys Lys Asn  Glu Arg Ala 
    1010                 1015                 1020             


Ile Arg  Arg Tyr Lys Thr Gln  Asp Met Ala Val Phe  Leu Met Ala 
    1025                 1030                 1035             


Lys Gln  Met Leu Ala Asn Gln  Leu Ser Trp Gln Asn  Gln Glu Gly 
    1040                 1045                 1050             


Glu Val  Pro Phe Lys Leu Ala  Asn Val Cys Lys Glu  Gly Phe Leu 
    1055                 1060                 1065             


Arg Gln  Thr Met Lys Val Ser  Phe Pro Tyr Glu Val  Pro Leu Lys 
    1070                 1075                 1080             


Glu Asp  Lys Thr Gln Lys Ala  Thr Ile Asn Ile Val  Gln Asp Asp 
    1085                 1090                 1095             


Met Ser  Leu Lys Asn Tyr Gly  Leu Leu Tyr Lys Leu  Tyr His Asp 
    1100                 1105                 1110             


Glu Arg  Val Val Thr Leu Leu  Gln Asn Ile Val Asp  Gln Gln Gln 
    1115                 1120                 1125             


Ile Ser  Phe Ala Glu Leu Thr  Ala Glu Leu Ser Leu  Tyr Asp Gln 
    1130                 1135                 1140             


Asn Arg  Ser Lys Ala Phe Ser  Asn Phe Gln Gln Phe  Glu Lys Leu 
    1145                 1150                 1155             


Ala Phe  Glu Thr Asn Lys Glu  Ala Leu Ser Asn Pro  Glu His Arg 
    1160                 1165                 1170             


Gly Phe  Phe Leu Glu Lys Val  Asn Lys Lys Asn Gln  Val Ile Arg 
    1175                 1180                 1185             


Tyr Glu  Arg Arg Asn Asn Phe  Asp Ala Leu Leu Asp  Leu Leu Asp 
    1190                 1195                 1200             


Ala Ile  Glu Ala His Gln Leu  Asp Pro Arg Glu Arg  Gln Trp Leu 
    1205                 1210                 1215             


Thr Ser  Val Arg Asn Ala Phe  Cys His Asn Ser Tyr  Tyr Lys Ile 
    1220                 1225                 1230             


Asp Met  Gln Gln Ile Glu Lys  Lys Leu Pro Thr Ile  Ile Gln Gln 
    1235                 1240                 1245             


Ile Val  Glu Ile Val Gln Arg  Ile Thr Asp Lys Ala  Ser His Pro 
    1250                 1255                 1260             


Ser Asn  Arg 
    1265     


<210>  2484
<211>  1141
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2484

Met Glu Asp Asp Lys Lys Thr Thr Glu Ser Thr Asn Met Leu Asp Asn 
1               5                   10                  15      


Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val Tyr 
            20                  25                  30          


Ile Thr Val Asn His Ile Asn Lys Val Leu Glu Leu Lys Asn Lys Lys 
        35                  40                  45              


Asp Gln Asp Ile Ile Ile Asp Asn Asp Gln Asp Ile Leu Ala Ile Lys 
    50                  55                  60                  


Thr His Trp Glu Lys Val Asn Gly Asp Leu Asn Lys Thr Glu Arg Leu 
65                  70                  75                  80  


Arg Glu Leu Met Thr Lys His Phe Pro Phe Leu Glu Thr Ala Ile Tyr 
                85                  90                  95      


Thr Lys Asn Lys Glu Asp Lys Glu Glu Val Lys Gln Glu Lys Gln Ala 
            100                 105                 110         


Lys Ala Gln Ser Phe Asp Ser Leu Lys His Cys Leu Phe Leu Phe Leu 
        115                 120                 125             


Glu Lys Leu Gln Glu Ala Arg Asn Tyr Tyr Ser His Tyr Lys Tyr Ser 
    130                 135                 140                 


Glu Ser Thr Lys Glu Pro Met Leu Glu Lys Glu Leu Leu Lys Lys Met 
145                 150                 155                 160 


Tyr Asn Ile Phe Asp Asp Asn Ile Gln Leu Val Ile Lys Asp Tyr Gln 
                165                 170                 175     


His Asn Lys Asp Ile Asn Pro Asp Glu Asp Phe Lys His Leu Asp Arg 
            180                 185                 190         


Thr Glu Glu Glu Phe Asn Tyr Tyr Phe Thr Arg Asn Lys Lys Gly Asn 
        195                 200                 205             


Ile Thr Ala Ser Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys 
    210                 215                 220                 


Lys Asp Ala Ile Trp Met Gln Gln Lys Leu Arg Gly Phe Lys Asp Asn 
225                 230                 235                 240 


Arg Glu Ser Lys Lys Lys Met Thr His Glu Val Phe Cys Arg Arg Arg 
                245                 250                 255     


Met Leu Leu Pro Lys Leu Arg Leu Glu Ser Thr Gln Thr Gln Asp Trp 
            260                 265                 270         


Ile Leu Leu Asp Met Leu Asn Glu Leu Ile Arg Cys Pro Lys Ser Leu 
        275                 280                 285             


Tyr Glu Arg Leu Gln Gly Glu Asp Arg Glu Lys Phe Lys Val Pro Phe 
    290                 295                 300                 


Asp Pro Ala Asp Glu Asp Tyr Asp Ala Glu Gln Glu Pro Phe Lys Asn 
305                 310                 315                 320 


Thr Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr 
                325                 330                 335     


Phe Asp Tyr Asn Glu Ile Phe Thr Asn Leu Arg Phe Gln Ile Asp Leu 
            340                 345                 350         


Gly Thr Tyr His Phe Ser Ile Tyr Lys Lys Leu Ile Gly Gly Gln Lys 
        355                 360                 365             


Glu Asp Arg His Leu Thr His Lys Leu Tyr Gly Phe Glu Arg Ile Gln 
    370                 375                 380                 


Glu Phe Ala Lys Gln Asn Arg Thr Asp Glu Trp Lys Ala Ile Val Lys 
385                 390                 395                 400 


Asp Leu Asp Thr Tyr Glu Thr Ser Asn Glu Arg Tyr Ile Ser Glu Thr 
                405                 410                 415     


Ile Pro His Tyr His Leu Glu Asn Gln Lys Ile Gly Ile Arg Phe Arg 
            420                 425                 430         


Asn Asp Asn Asp Glu Ile Trp Pro Ser Leu Lys Thr Asn Gly Glu Asn 
        435                 440                 445             


Asn Glu Lys Arg Lys Tyr Lys Leu Asp Lys Gln Tyr Gln Ala Glu Ala 
    450                 455                 460                 


Phe Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu 
465                 470                 475                 480 


Leu Lys Met Glu Asn Thr Asp Asn Gly Lys Glu Asn Asn Glu Val Gly 
                485                 490                 495     


Thr Lys Lys Lys Arg Asn Lys Asn Asn Glu Gln Glu Lys His Lys Ile 
            500                 505                 510         


Glu Glu Ile Ile Glu Asn Lys Ile Lys Asp Ile Tyr Ala Leu Tyr Asp 
        515                 520                 525             


Ala Phe Ala Asn Gly Glu Ile Asn Ser Glu Glu Glu Leu Lys Glu Tyr 
    530                 535                 540                 


Leu Lys Gly Lys Asp Ile Glu Ile Val His Leu Pro Lys Gln Met Ile 
545                 550                 555                 560 


Ala Ile Leu Glu Ser Lys Pro Lys Asp Met Val Lys Glu Ala Lys Arg 
                565                 570                 575     


Lys Gln Lys Glu Met Val Lys Asp Thr Lys Lys Leu Leu Ala Ala Leu 
            580                 585                 590         


Glu Lys Gln Thr Gln Gly Glu Ile Glu Asp Gly Gly Arg Asn Ile Arg 
        595                 600                 605             


Leu Leu Lys Ser Gly Glu Ile Ala Arg Trp Leu Val Asn Asp Met Met 
    610                 615                 620                 


Arg Phe Gln Pro Val Gln Lys Asp Asn Glu Gly Asn Pro Leu Asn Asn 
625                 630                 635                 640 


Ser Lys Ala Asn Ser Thr Glu Tyr Gln Met Leu Gln Arg Ser Leu Ala 
                645                 650                 655     


Leu Tyr Asn Lys Glu Glu Lys Pro Thr Arg Tyr Phe Arg Gln Val Asn 
            660                 665                 670         


Leu Ile Asn Ser Ser Asn Pro His Pro Phe Leu Lys Trp Thr Lys Trp 
        675                 680                 685             


Glu Glu Cys Asn Asn Ile Leu Ser Phe Tyr Arg Ser Tyr Leu Thr Lys 
    690                 695                 700                 


Lys Ile Glu Phe Leu Asn Lys Leu Lys Pro Glu Glu Trp Lys Lys Asn 
705                 710                 715                 720 


Gln Tyr Phe Leu Lys Leu Lys Glu Pro Lys Thr Asn Arg Glu Thr Leu 
                725                 730                 735     


Val Gln Gly Trp Lys Asn Gly Phe Asn Leu Pro Arg Gly Ile Phe Thr 
            740                 745                 750         


Glu Pro Ile Arg Glu Trp Phe Lys Arg His Gln Asn Asp Ser Lys Glu 
        755                 760                 765             


Tyr Glu Lys Val Glu Ala Leu Asp Arg Val Gly Leu Val Ala Lys Val 
    770                 775                 780                 


Ile Pro Leu Phe Phe Lys Glu Glu Tyr Phe Lys Glu Asp Ala Gln Lys 
785                 790                 795                 800 


Glu Ile Asn Asn Cys Val Gln Pro Phe Tyr Ser Phe Pro Tyr Asn Val 
                805                 810                 815     


Gly Asn Ile His Lys Pro Asp Glu Lys Asp Phe Leu Pro Ser Glu Glu 
            820                 825                 830         


Arg Lys Lys Arg Trp Gly Asp Lys Lys Tyr Lys Phe Lys Gly Tyr Lys 
        835                 840                 845             


Ala Lys Val Lys Ser Lys Lys Leu Thr Asp Lys Glu Lys Glu Glu Tyr 
    850                 855                 860                 


Arg Ser Tyr Leu Glu Phe Gln Ser Trp Asn Lys Phe Glu Arg Glu Leu 
865                 870                 875                 880 


Arg Leu Val Arg Asn Gln Asp Ile Val Thr Trp Leu Leu Cys Thr Glu 
                885                 890                 895     


Leu Ile Asp Lys Leu Lys Val Glu Gly Leu Asn Val Glu Glu Leu Gln 
            900                 905                 910         


Lys Leu Arg Leu Lys Asp Ile Asp Thr Asp Thr Ala Lys Gln Glu Lys 
        915                 920                 925             


Asn Asn Ile Leu Asn Arg Ile Met Pro Met Gln Leu Pro Val Thr Val 
    930                 935                 940                 


Tyr Glu Ile Asp Asp Ser His Asn Ile Val Lys Asp Lys Pro Leu His 
945                 950                 955                 960 


Thr Val Tyr Ile Glu Glu Thr Lys Thr Lys Leu Leu Lys Gln Gly Asn 
                965                 970                 975     


Phe Lys Ala Leu Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe 
            980                 985                 990         


Val Asp Thr Ser Ser Lys Ala Glu  Leu Lys Asp Lys Pro  Ile Ser Lys 
        995                 1000                 1005             


Ser Val  Val Glu Tyr Glu Leu  Gly Glu Tyr Gln Asn  Ala Arg Ile 
    1010                 1015                 1020             


Glu Thr  Ile Lys Asp Met Leu  Leu Leu Glu Glu Thr  Leu Ile Lys 
    1025                 1030                 1035             


Lys Tyr  Lys Thr Leu Pro Thr  Asn Lys Phe Ser Ala  Met Leu Asn 
    1040                 1045                 1050             


Gly Trp  Leu Glu Gly Lys Asp  Glu Ala Asp Lys Ala  Arg Phe Gln 
    1055                 1060                 1065             


Asn Asp  Val Lys Leu Leu Val  Ala Val Arg Asn Ala  Phe Ser His 
    1070                 1075                 1080             


Asn Gln  Tyr Pro Met Arg Asn  Arg Ile Ala Phe Ala  Asn Ile Asn 
    1085                 1090                 1095             


Pro Phe  Ser Leu Ser Ser Ala  Asn Thr Ser Glu Glu  Lys Lys Leu 
    1100                 1105                 1110             


Asp Ile  Ala Asn Gln Leu Lys  Asp Lys Thr His Lys  Thr Ile Glu 
    1115                 1120                 1125             


Lys Ile  Ile Glu Ile Glu Lys  Pro Ile Glu Thr Lys  Glu 
    1130                 1135                 1140     


<210>  2485
<211>  1119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2485

Met Glu Asp Asp Lys Lys Thr Thr Glu Ser Ile Ser Tyr Glu Leu Glu 
1               5                   10                  15      


Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val 
            20                  25                  30          


Tyr Ile Thr Ile Asn His Ile Asn Lys Leu Leu Glu Ile Arg Glu Ile 
        35                  40                  45              


Asp Asn Asp Glu Lys Val Leu Asp Ile Lys Ala Leu Trp Gln Lys Gly 
    50                  55                  60                  


Asn Lys Asp Leu Asn Gln Lys Ala Arg Leu Arg Glu Leu Met Thr Lys 
65                  70                  75                  80  


His Phe Pro Phe Leu Glu Thr Ala Ile Tyr Thr Lys Asn Lys Glu Asp 
                85                  90                  95      


Lys Glu Glu Val Lys Gln Glu Lys Gln Ala Glu Ala Gln Ser Leu Glu 
            100                 105                 110         


Ser Leu Lys Asp Cys Leu Phe Leu Phe Leu Glu Lys Leu Gln Glu Ala 
        115                 120                 125             


Arg Asn Tyr Tyr Ser His Tyr Lys Tyr Ser Glu Phe Ser Lys Glu Pro 
    130                 135                 140                 


Glu Phe Lys Glu Glu Leu Leu Glu Lys Met Tyr Asn Ile Phe Asp Ala 
145                 150                 155                 160 


Asn Ile Gln Leu Val Ile Asn Asp Tyr Gln His Asn Lys Asp Ile Asp 
                165                 170                 175     


Pro Glu Glu Asp Phe Lys His Leu Asp Thr Ile Glu Asp Ser Ser Tyr 
            180                 185                 190         


Ser Phe Thr Val Lys Asp Asn Lys Glu Lys Ile Thr Ala Ser Gly Leu 
        195                 200                 205             


Leu Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Met 
    210                 215                 220                 


Gln Gln Lys Leu Thr Gly Phe Lys Asp Asn Arg Glu Ser Lys Lys Lys 
225                 230                 235                 240 


Met Thr His Glu Val Phe Cys Arg Ser Arg Met Leu Leu Pro Lys Leu 
                245                 250                 255     


Arg Leu Lys Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu 
            260                 265                 270         


Asn Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Gln Gly 
        275                 280                 285             


Glu Asp Arg Glu Lys Phe Arg Val Pro Leu Asp Pro Ile Asp Glu Asp 
    290                 295                 300                 


Tyr Asp Ala Glu Gln Glu Pro Phe Lys Asn Thr Leu Val Arg His Gln 
305                 310                 315                 320 


Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Tyr Asn Glu Val 
                325                 330                 335     


Phe Thr Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser 
            340                 345                 350         


Ile Tyr Lys Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg His Leu Thr 
        355                 360                 365             


His Lys Leu Tyr Gly Phe Glu Arg Ile Gln Glu Phe Ala Lys Gln Asn 
    370                 375                 380                 


Arg Thr Asp Glu Trp Lys Ala Leu Val Lys Asp Leu Asp Thr Tyr Glu 
385                 390                 395                 400 


Thr Ser Asn Glu Arg Tyr Ile Ser Glu Thr Thr Pro His Tyr His Leu 
                405                 410                 415     


Glu Asn Gln Lys Ile Gly Ile Arg Lys Lys Lys Lys Lys Lys Asn Ile 
            420                 425                 430         


Trp Pro Ser Leu Glu Ile Asn Thr Thr Val Asn Glu Arg Ser Lys Tyr 
        435                 440                 445             


Asn Leu Gly Lys Ser Phe Lys Ala Glu Ala Phe Leu Ser Val His Glu 
    450                 455                 460                 


Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Thr Lys Glu Glu Pro 
465                 470                 475                 480 


Asn Asn Lys Glu Ile Asn Ala Ser Lys Val Glu Gly Ile Ile Glu Lys 
                485                 490                 495     


Lys Ile Arg Asp Met Tyr Lys Leu Tyr Asp Ala Phe Ala Asn Gly Glu 
            500                 505                 510         


Ile Asn Ser Lys Glu Glu Leu Lys Glu Tyr Leu Lys Gly Lys Asp Ile 
        515                 520                 525             


Glu Ile Val His Leu Pro Lys Gln Met Ile Ala Ile Leu Glu Ser Lys 
    530                 535                 540                 


Pro Lys Asp Met Val Lys Glu Ala Lys Arg Lys Gln Lys Glu Met Val 
545                 550                 555                 560 


Lys Asp Thr Lys Lys Leu Leu Ala Thr Leu Glu Lys Gln Thr Gln Glu 
                565                 570                 575     


Glu Ile Glu Asp Gly Gly Arg Asn Ile Arg Leu Leu Lys Ser Gly Glu 
            580                 585                 590         


Ile Ala Arg Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln 
        595                 600                 605             


Lys Asp Asn Glu Gly Asn Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr 
    610                 615                 620                 


Glu Tyr Gln Met Leu Gln Arg Ser Leu Ala Leu Tyr Asn Lys Glu Glu 
625                 630                 635                 640 


Lys Pro Thr Arg Tyr Phe Arg Gln Val Asn Leu Ile Asn Ser Ser Asn 
                645                 650                 655     


Pro His Pro Phe Leu Lys Trp Thr Lys Trp Glu Glu Cys Asn Asn Ile 
            660                 665                 670         


Leu Ser Phe Tyr Arg Asn Tyr Leu Thr Lys Lys Ile Glu Phe Leu Asn 
        675                 680                 685             


Lys Leu Lys Pro Glu Asp Trp Glu Lys Asn Gln Tyr Phe Leu Lys Leu 
    690                 695                 700                 


Lys Glu Pro Lys Thr Asn Arg Glu Thr Leu Val Gln Gly Trp Lys Asn 
705                 710                 715                 720 


Gly Phe Asn Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg Glu Trp 
                725                 730                 735     


Phe Lys Arg His Gln Asn Asp Ser Lys Glu Tyr Glu Lys Val Glu Ala 
            740                 745                 750         


Leu Lys Arg Val Gly Leu Val Thr Lys Val Ile Pro Leu Phe Phe Lys 
        755                 760                 765             


Glu Glu Tyr Phe Lys Glu Asp Ala Gln Lys Glu Ile Asn Asn Cys Val 
    770                 775                 780                 


Gln Pro Phe Tyr Gly Phe Pro Tyr Asn Val Gly Asn Ile His Lys Pro 
785                 790                 795                 800 


Asp Glu Lys Asp Phe Leu Ser Ser Glu Glu Arg Lys Lys Leu Trp Gly 
                805                 810                 815     


Asp Lys Lys Tyr Lys Phe Lys Gly Tyr Lys Ala Lys Val Lys Ser Lys 
            820                 825                 830         


Lys Leu Thr Asp Lys Glu Lys Glu Glu Tyr Arg Ser Tyr Leu Glu Phe 
        835                 840                 845             


Gln Ser Trp Asn Lys Phe Glu Arg Glu Leu Arg Leu Val Arg Asn Gln 
    850                 855                 860                 


Asp Ile Val Thr Trp Leu Leu Cys Thr Glu Leu Ile Asp Lys Leu Lys 
865                 870                 875                 880 


Val Glu Gly Leu Asn Val Glu Glu Leu Lys Lys Leu Arg Leu Lys Asp 
                885                 890                 895     


Ile Asp Thr Asp Thr Ala Lys Gln Glu Lys Asn Asn Ile Leu Asn Arg 
            900                 905                 910         


Val Met Pro Met Gln Leu Pro Val Thr Val Tyr Glu Ile Asp Asp Ser 
        915                 920                 925             


His Asn Ile Val Lys Asp Arg Pro Leu His Thr Val Tyr Ile Glu Glu 
    930                 935                 940                 


Thr Lys Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys 
945                 950                 955                 960 


Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Val Asp Thr Ser Ser Glu 
                965                 970                 975     


Ala Glu Leu Lys Ser Lys Pro Ile Ser Lys Ser Val Val Glu Tyr Glu 
            980                 985                 990         


Leu Gly Glu Tyr Gln Asn Ala Arg  Ile Glu Ile Ile Glu  Asp Met Leu 
        995                 1000                 1005             


Ala Leu  Glu Gly Ala Leu Ile  Lys Lys Asp Lys Asn  Leu Pro Thr 
    1010                 1015                 1020             


Asp Asn  Phe Ser Asp Met Leu  Asn Gly Trp Leu Glu  Gly Lys Asp 
    1025                 1030                 1035             


Glu Ser  Asp Lys Ala Arg Phe  Gln Asn Asp Val Lys  Leu Leu Val 
    1040                 1045                 1050             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Arg Asn 
    1055                 1060                 1065             


Arg Ile  Ala Phe Ala Asn Ile  Asn Pro Phe Ser Leu  Ser Ser Ala 
    1070                 1075                 1080             


Asp Thr  Ser Glu Glu Lys Lys  Leu Asp Ile Ala Asn  Gln Leu Lys 
    1085                 1090                 1095             


Asp Lys  Thr His Lys Thr Ile  Glu Lys Ile Ile Glu  Ile Glu Lys 
    1100                 1105                 1110             


Pro Ile  Glu Thr Lys Glu 
    1115                 


<210>  2486
<211>  1134
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2486

Met Asn Glu Thr Asp Tyr Leu Ala Lys Arg Leu Glu Tyr Asn Tyr Ala 
1               5                   10                  15      


Ser Ile Glu Asp Lys His Tyr Phe Gly Gly Tyr Phe Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asn Asp Leu Ser Lys Ala Phe Lys Glu Lys Phe Gly Met 
        35                  40                  45              


Lys Pro Lys Ser Cys Ile Leu Asp Phe Phe Thr Gln Asp Lys Ala Ile 
    50                  55                  60                  


Ala Glu Tyr Gln Leu Gly Val Glu Phe Leu Gln Lys Asn Leu Pro Val 
65                  70                  75                  80  


Ile Arg Tyr Leu Tyr Leu Pro Thr Ser His Lys Arg Phe Glu Asn Val 
                85                  90                  95      


Pro Lys Asn Gln Leu Ile Ser Glu Gln Arg Asn Tyr Phe Lys Asn Ser 
            100                 105                 110         


Leu Lys Val Leu Lys Asn Leu Ile Arg Asp Tyr Arg Asn Phe Tyr Thr 
        115                 120                 125             


His His Phe His Lys Pro Ile Pro Val Phe Pro Glu Thr Tyr Lys Leu 
    130                 135                 140                 


Leu Asp Asp Leu Phe Leu Ala Val Ala Asn Asp Val Lys Lys His Arg 
145                 150                 155                 160 


Met Lys Thr Asp Ala Ser Lys Gln Leu Leu Lys Lys Gly Leu Ile Glu 
                165                 170                 175     


Glu Leu Ala Gln Leu Glu Lys Leu Lys Leu Glu Asp Leu Lys Lys Leu 
            180                 185                 190         


Lys Arg Glu Gly Lys Lys Val Asn Leu Asn Asp Lys Glu Ala Ile Thr 
        195                 200                 205             


Asn Ala Ile Leu Asn Asp Ser Phe Ser His Leu Leu Pro Lys Glu Asn 
    210                 215                 220                 


Thr Ile Ser Lys Tyr Tyr Ser Ala Val Pro Thr Glu Asp Ile Asp Thr 
225                 230                 235                 240 


Glu Asn Gly Val Thr Ile Ser Glu Ser Gly Ile Ile Phe Leu Leu Gly 
                245                 250                 255     


Leu Phe Leu Thr Lys Lys Gln Ser Glu Asp Leu Arg Ser Arg Val Lys 
            260                 265                 270         


Gly Phe Lys Ala Lys Leu Ile Val Asn Pro Glu Asn Pro Ile Asn Lys 
        275                 280                 285             


Lys Asn Asn Ser Leu Lys Tyr Met Ala Thr His Trp Val Phe Gly Tyr 
    290                 295                 300                 


Leu Gly Phe Lys Gly Leu Lys Asn Arg Phe Thr Thr Thr Phe Thr Lys 
305                 310                 315                 320 


Asp Thr Leu Leu Ala Gln Ile Val Asp Glu Leu Ser Lys Val Pro Asp 
                325                 330                 335     


Glu Leu Tyr Gln Val Leu Pro Glu Glu Leu Lys Asn Glu Phe Leu Glu 
            340                 345                 350         


Asp Met Asn Glu Tyr Leu Lys Glu Glu Asn Ser Glu Ser Leu Asp Lys 
        355                 360                 365             


Ala Thr Val Ile His Pro Val Ile Arg Lys Arg Tyr Glu Asn Lys Phe 
    370                 375                 380                 


Ala Tyr Phe Ala Leu Arg Phe Leu Asp Glu Phe Val Asp Phe Pro Thr 
385                 390                 395                 400 


Leu Arg Phe Gln Leu His Leu Gly Asn Tyr Val His Asp Lys Arg Glu 
                405                 410                 415     


Lys Pro Ile Glu Gly Thr Lys Tyr Val Thr Glu Arg Ile Val Lys Glu 
            420                 425                 430         


Lys Ile Lys Ala Phe Ala Lys Leu Ser Glu Ala Ala Gln Leu Lys Gln 
        435                 440                 445             


Lys Tyr Phe Glu Glu Lys Glu Asn His Gln Ser Ile Gly Leu Gln Leu 
    450                 455                 460                 


Tyr Pro Asn Pro Ser Tyr Asn Phe Val Gly Asn Asn Ile Pro Ile His 
465                 470                 475                 480 


Leu Asn Leu Asn Glu His Phe Phe Pro Lys Glu Val Lys Ile Val Ala 
                485                 490                 495     


Gly Arg Leu Lys Lys Arg Asn Ser Ser Tyr Lys Ser Asp His Pro Glu 
            500                 505                 510         


Glu Tyr Lys Val Arg Thr Asp Asn Lys Ile Lys Pro Asp Ala Ile Leu 
        515                 520                 525             


Gln Asp Leu Gly Lys Pro Glu Lys Leu Ala Pro Val Ala Met Leu Ser 
    530                 535                 540                 


Leu Asn Glu Leu Pro Ala Leu Leu His Leu Val Leu Thr Lys Lys Thr 
545                 550                 555                 560 


Pro Glu Glu Ile Glu Ile Ile Ile Ala Gln Lys Ile Ala Glu Arg Tyr 
                565                 570                 575     


Asn Val Leu Thr Asn Tyr Lys Ala Gly Asp Asp Ile Ser Lys Gly Gln 
            580                 585                 590         


Ile Thr Lys Asn Leu Leu Lys Ala Lys Gln Lys Lys Glu Val Asn Leu 
        595                 600                 605             


Asp Lys Leu Gln Leu Ala Ile Glu Lys Glu Ile Ala Val Thr Asn Asp 
    610                 615                 620                 


Lys Leu Gln Thr Ile Ala Leu His Ile Lys Glu Arg Asn Asp Pro Lys 
625                 630                 635                 640 


Gln Lys Arg Lys Tyr Val Phe Thr Asn Lys Glu Ile Gly Leu Gln Val 
                645                 650                 655     


Thr Trp Leu Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Gly Ser Arg 
            660                 665                 670         


Gln Asn Trp Arg Gly Gln His His Ser Gln Leu Gln Lys Ser Leu Ala 
        675                 680                 685             


Phe Tyr Asp Ile Gln Pro Lys Glu Pro Leu Ser Leu Leu Glu Glu Val 
    690                 695                 700                 


Trp Asp Phe Lys Asn Glu Ala Tyr Leu Trp Asn Asn Gly Ile Arg Arg 
705                 710                 715                 720 


Ser Phe Asp Lys Arg Asp Phe Ile Ser Phe Tyr Thr Ser Tyr Leu Asn 
                725                 730                 735     


Asn Arg Lys Glu Thr Phe Gln Arg Phe Lys Asp Gln Leu Asn Gly Ile 
            740                 745                 750         


Arg Ser Asn Lys Lys Ile Leu Asp Lys Phe Ile Lys Gln Gln His Leu 
        755                 760                 765             


Trp Asn Leu Phe His Lys Arg Leu Tyr Val Ile Asp Thr Ile Glu Glu 
    770                 775                 780                 


Gln Val Glu Lys Leu Leu Val Lys Pro Met Gln Phe Pro Lys Gly Val 
785                 790                 795                 800 


Phe Asp His Lys Pro Thr Tyr Ile Lys Gly Lys Ser Ile Gln Glu Asn 
                805                 810                 815     


Pro Glu Cys Phe Ala Asp Trp Tyr Val Ala Trp Asn Gln His Thr Asp 
            820                 825                 830         


Tyr Gln Lys Phe Tyr Ser Trp Asp Arg Asp Tyr Lys Ser Ala Tyr Leu 
        835                 840                 845             


Ser Gly Glu Gln Glu Lys Thr Glu Lys Arg Phe Ile Arg Val Gln Gly 
    850                 855                 860                 


Ser Lys Ile Asn Lys Val Lys Gln Gln Asp Val Leu Leu Ala Lys Met 
865                 870                 875                 880 


Ala Ser Ile Ile Phe Asn Glu Leu Tyr Leu Pro Glu Asp Ala Glu His 
                885                 890                 895     


Leu Asp Leu Asn Leu Ser Asp Ile Tyr Lys Thr Gln Thr Glu Arg Lys 
            900                 905                 910         


Ala Glu Ile Glu Ala Ala Leu Ile Gln Ser His Lys Thr Thr Gly Asp 
        915                 920                 925             


Asn Ser Ala Asn Ile Ile Lys Ser Thr Ser Ala Trp Thr Leu Thr Val 
    930                 935                 940                 


Pro Tyr Cys Ser Lys Asn Ile Tyr Glu Pro Gln Val Lys Leu Lys Glu 
945                 950                 955                 960 


Leu Gly Lys Phe Lys Lys Phe Ile Ala Ser Gln Lys Val Gln Thr Leu 
                965                 970                 975     


Phe Glu Tyr Lys Pro Gln Lys Ile Trp Asn Lys Thr Glu Leu Glu Glu 
            980                 985                 990         


Val Leu Glu Leu Lys Ala Asn Ser  Tyr Glu Val Ile Arg  Arg Asp Tyr 
        995                 1000                 1005             


Leu Leu  Lys Ser Ile Gln Glu  Phe Glu Lys Tyr Met  Ile Lys Lys 
    1010                 1015                 1020             


Leu Pro  Thr Leu Ile Asp Thr  Asn Glu His Pro Asn  Phe Asn Lys 
    1025                 1030                 1035             


Tyr Leu  Thr Thr Phe Leu Lys  Ser Leu Glu Leu Val  Ser Glu Glu 
    1040                 1045                 1050             


Asp Ala  Lys Trp Leu Ile Ser  Lys Lys Asp Phe Asp  Thr Thr Pro 
    1055                 1060                 1065             


Ile Asp  Glu Leu Lys Lys Gln  Ser Lys Ile Met Glu  Lys Ala Phe 
    1070                 1075                 1080             


Leu Leu  Val Met Ile Arg Asn  Lys Phe Ser His Asn  Gln Leu Pro 
    1085                 1090                 1095             


Arg Lys  Ile Tyr Tyr Asp Glu  Ile Tyr Lys Asn Val  Pro Asn Ala 
    1100                 1105                 1110             


Val Ser  Ile Asn Phe Asn Glu  Leu Phe Leu Glu Tyr  Thr Asn Gln 
    1115                 1120                 1125             


Thr Ile  Leu Glu Phe Lys 
    1130                 


<210>  2487
<211>  1242
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2487

Met Glu Gln Asn Arg Lys Glu Gly Ser Leu Arg Thr Gln Glu Asp Ile 
1               5                   10                  15      


Gln Tyr Phe Gly Ser Tyr Phe Asn Met Ala Arg His Asn Leu Tyr Leu 
            20                  25                  30          


Ile Thr Asn His Leu Thr Ser Val Phe Ser His Leu Asn Phe Ser Gln 
        35                  40                  45              


Leu Asp Asp Asp Glu Asp Ile Trp Ser Asp Lys Pro Glu Val Asn Glu 
    50                  55                  60                  


Lys Asn Ile Leu Leu Asn Ile Phe Asp Thr Lys Asn Glu Arg Leu Gln 
65                  70                  75                  80  


Asp Glu Arg Ile Arg Val Phe Arg Tyr Leu Met Arg Arg His His Leu 
                85                  90                  95      


Pro Cys Leu Arg Ile Phe Thr Asn Asp Phe Lys Val Leu Glu Thr Thr 
            100                 105                 110         


Gly Asn Thr Ile Lys Lys Asp Glu Leu Glu Val Asp Phe Asp Ala Val 
        115                 120                 125             


His Lys Phe Leu Asn Ile Ala Phe Lys Glu Ile Asn Leu Phe Arg Asn 
    130                 135                 140                 


Ser Tyr Thr His Tyr Leu Ser Ile Asn Glu Glu Gly Lys Arg Leu Lys 
145                 150                 155                 160 


Lys Lys Lys Lys Ile Ser Ser Lys Leu Val Pro Val Leu Asn Ser Leu 
                165                 170                 175     


Phe Ser Tyr Ala Pro Glu Tyr Ser Phe Leu Arg His Asn Ile Asp Lys 
            180                 185                 190         


Ala Asn Lys Asp Val Lys Ile Tyr Lys Glu Glu Val Lys Glu Tyr Tyr 
        195                 200                 205             


Asp Asn Ile Lys Ser Lys Tyr Lys Leu Phe Glu Asn Asp Ser Asn Glu 
    210                 215                 220                 


Leu Thr Asp Gln Gly Met Tyr Phe Phe Ile Thr Leu Phe Leu Glu Arg 
225                 230                 235                 240 


Ala His Gly Ile Lys Phe Leu Lys Arg Phe Arg Gly Phe Lys Asn Glu 
                245                 250                 255     


Thr Thr Pro Pro Phe Lys Ala Thr Ile Gln Ala Phe Thr Thr Tyr Thr 
            260                 265                 270         


Leu Lys Ile Pro Asp Val Arg Leu Asp Asn Asp Ile Pro Glu Gln Thr 
        275                 280                 285             


Met Ile Met Glu Val Leu Asn Glu Leu Asn Lys Cys Pro Glu Glu Leu 
    290                 295                 300                 


Phe Lys Phe Leu Lys Lys Glu Asp Lys Asp Arg Phe Gln Pro Val Ile 
305                 310                 315                 320 


Ser Asp Glu Ser Leu Thr Asn Ile Ile Asn Ser Ser Asn Tyr Glu Glu 
                325                 330                 335     


Ile Ser Asp Glu Asp Ile Asp Arg Leu Ile Lys Glu Asn Ser Val Leu 
            340                 345                 350         


Lys Arg Arg Glu Asp Arg Phe Pro Tyr Phe Ala Leu Gln Tyr Leu Glu 
        355                 360                 365             


Ile Met Ser Lys Leu Lys Asn Ile Arg Phe Gln Ile Tyr Leu Gly Lys 
    370                 375                 380                 


Leu Val Leu Lys Thr Tyr Asp Lys Glu Asn Pro Asn Ile Glu Arg Arg 
385                 390                 395                 400 


Val Ile Thr Asp Ile His Ala Phe Gly Lys Leu Ser Asp Phe Val Gly 
                405                 410                 415     


Lys Glu Ala Glu Val Leu Asp Thr Phe Asn Ser Gln Leu Lys Asp Tyr 
            420                 425                 430         


Gly Tyr Ser Val Ala Trp Asp Gln Tyr Lys Pro Ser Tyr Ala Ile Glu 
        435                 440                 445             


Met Asn Arg Ile Gly Phe Tyr Leu Phe Asn Asp Gln Gly Asp Lys Val 
    450                 455                 460                 


Glu Asn Lys Ile Leu Pro Ser Leu Cys Lys Asn Lys Asn Leu Glu Arg 
465                 470                 475                 480 


Lys Val Glu Ile Lys Val Asn Lys Ile Gln Pro Thr Gly Phe Ile Ser 
                485                 490                 495     


Thr His Met Leu Pro Lys Phe Leu Ile Ser Tyr Leu Met Gly Asp Val 
            500                 505                 510         


Asn Glu Lys Asn Gly Glu Lys Thr Ile Thr His Phe Leu Glu Lys Val 
        515                 520                 525             


Asn Val Ser Ile Leu Asp Gln Asn Ile Ile Asn Gln Ile Lys Ser Glu 
    530                 535                 540                 


Ile Gln Asn Leu Asp Pro Ile Glu Phe Thr Lys Arg Cys Pro Lys Leu 
545                 550                 555                 560 


Ser Ala Ile Lys Asn Val Lys Lys Leu Arg Val Ala Gly Ala Ile Asp 
                565                 570                 575     


Lys Lys Ile Val Glu Tyr Gln Tyr Ile Asn Asp Thr Asp Ile Ala Lys 
            580                 585                 590         


Leu Val Gln Lys Thr Gly Leu Ala Tyr Asp Thr Met Val Thr Tyr Ser 
        595                 600                 605             


Lys Asp Lys Phe Lys Glu Lys Thr Asn His Leu Asn Leu Ser Lys Lys 
    610                 615                 620                 


Glu Leu Glu Thr Phe Ala His Ile Lys Tyr Lys Tyr Tyr Leu Ser Glu 
625                 630                 635                 640 


Arg Arg Lys Ala Leu Asp Ser Val Leu Lys Ala Tyr Phe Pro Glu Ile 
                645                 650                 655     


Gly Ser Gln Asp Ile Pro Lys Glu Leu Tyr Asn Tyr Leu Leu Asn Ile 
            660                 665                 670         


Asn Glu Gln Asp Asn Lys Lys Leu Glu His Arg Arg Ile Lys Asp Glu 
        675                 680                 685             


Val Thr Lys Thr Lys Lys Leu Ile Lys Asp Val Asn Arg Ser Leu Lys 
    690                 695                 700                 


Phe Glu Asp Lys Ile Leu Leu Gly Asp Leu Ala Thr Lys Ile Ala Arg 
705                 710                 715                 720 


Asp Ile Ile Asn Met Ile Ile Asp Lys Asp Leu Lys Val Ser Met Thr 
                725                 730                 735     


Asn Pro Phe Ala Asn Arg Leu Gln Asn Leu Ile Ala Tyr Phe Ser Thr 
            740                 745                 750         


Asn Lys Glu Ala Ile Val Ala Leu Cys Glu Ser Tyr Lys Val Phe Glu 
        755                 760                 765             


His Asn Lys Gly His Phe Phe Leu Thr Arg Glu Leu Ile Leu Asn Ser 
    770                 775                 780                 


Thr Gly Val Ile Asp Phe Tyr Ile Arg Tyr Phe Glu Ala Lys Ile Glu 
785                 790                 795                 800 


Lys Ile Lys Glu Val Leu Leu Val Arg Gly Lys Glu Gly Gly Tyr Glu 
                805                 810                 815     


Ile Asn Thr Glu Leu Ile Pro Tyr Ser Tyr Thr Gln Tyr Leu Pro Lys 
            820                 825                 830         


Glu Val Lys Glu Glu Asn Lys Asn Thr Cys Lys Asn Leu Phe Glu Gln 
        835                 840                 845             


Trp Leu Tyr Tyr Lys Gln Lys Ser Pro Val Asn Leu Pro Val Thr Leu 
    850                 855                 860                 


Leu Asp Glu Asp Leu Thr Ser Ala Leu Lys Ser Lys Leu Lys Leu Lys 
865                 870                 875                 880 


Pro Asp Leu Lys Asp Gly Phe Ser Lys Leu Ile Gln Leu Tyr Leu Lys 
                885                 890                 895     


Asp Asp Ala Gln Glu Phe Tyr Ser Phe Asp Arg Val Tyr Arg Asn Asn 
            900                 905                 910         


Asp Asn Glu His Val Ile Lys Tyr Ser Asn Glu Gly Ser Ser Lys Glu 
        915                 920                 925             


Met Gln Ile Lys Tyr Gly Lys Val Ala Val Glu Ser Glu Lys Ile Ile 
    930                 935                 940                 


Arg His Val Leu Leu Lys Asp Arg Ile Leu Arg Val Ile Cys Glu Asp 
945                 950                 955                 960 


Leu Leu Lys Ser Asp Lys Asn Thr Ser Ser Thr Lys Ser Phe Leu Leu 
                965                 970                 975     


Lys Asp Ile Ser Pro Trp Ser Glu Thr Asn Ile Leu Asn Lys Pro Asn 
            980                 985                 990         


Glu Phe Ser Tyr Asn Leu Arg Lys  Asn Ile Asp Gly Ser  Gly Thr Glu 
        995                 1000                 1005             


Tyr Cys  Thr Ile Val Ala Lys  Asp Ser Thr Glu Gln  Ile Arg Gln 
    1010                 1015                 1020             


Ile Asn  Glu Trp Asn Asp Leu  Ser Lys Glu Ile Lys  Ser Lys Phe 
    1025                 1030                 1035             


Leu Lys  Leu Asn Ala Glu Gln  Lys Ile Asp Phe Leu  Thr Thr Gln 
    1040                 1045                 1050             


Asp Glu  Lys Thr Lys Leu Val  Leu Leu Gly Gln Gln  Asn Tyr Gln 
    1055                 1060                 1065             


Trp Lys  Phe Ser Asp Phe Gly  Arg Phe Arg Arg Phe  Met Lys Asp 
    1070                 1075                 1080             


Lys Arg  Ile Asn Glu Met Val  Lys Tyr Phe Glu Pro  Lys Gln Ile 
    1085                 1090                 1095             


Pro Phe  Asp Leu Leu Glu Phe  Gln Ile Leu Gln Tyr  Asn Ile Tyr 
    1100                 1105                 1110             


Arg Glu  Lys Met Phe Asp Lys  Ile Phe Glu Leu Glu  Arg Val Met 
    1115                 1120                 1125             


Ser Glu  Arg Tyr Phe Glu Asp  Ile Lys Ser Lys His  Leu Glu Asn 
    1130                 1135                 1140             


Phe Lys  Tyr Asn Glu Val Gly  Phe Gln Thr Tyr Leu  Asn Val Leu 
    1145                 1150                 1155             


Ser Glu  Lys Ile Ala Ser Gly  Tyr Asp Ile Ala Ile  Leu Lys Trp 
    1160                 1165                 1170             


Gly Arg  Asn Lys Phe Ser His  Thr Glu Ile Val Tyr  Tyr Asn Phe 
    1175                 1180                 1185             


Ile Ser  Lys Ile Ala Val Gln  Asp Ile Glu Glu Phe  Glu Leu Lys 
    1190                 1195                 1200             


Lys His  Leu Glu Gly Tyr Lys  Glu Asn Val Ser Phe  Asn Ile Ala 
    1205                 1210                 1215             


Arg Asn  Ile Tyr Arg Val Phe  Ser Arg Glu Val Asp  Lys Thr Ile 
    1220                 1225                 1230             


Asn Leu  Ile Asn Asn Ser Phe  Lys Ile 
    1235                 1240         


<210>  2488
<211>  905
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2488

Met Lys Glu Asn Thr Ile Ser Lys Glu Lys Ser Ala Tyr Thr Pro His 
1               5                   10                  15      


Pro Lys Thr Glu Leu Cys Ile Ala Leu Asn Leu Ala Arg Gln Arg Phe 
            20                  25                  30          


Val Glu Val Leu Arg Tyr Val Leu Asp Asp Asp Asn Ile Thr Glu Glu 
        35                  40                  45              


Asn Trp Lys Thr Pro Phe Gln Glu Lys Ser Gln Lys Gln Ile Asn Ser 
    50                  55                  60                  


Ile Glu Leu Lys Gln Lys Trp Leu Leu Lys Gln Gln Gln Leu Leu Lys 
65                  70                  75                  80  


Glu Leu Ser Ile Tyr Leu Pro Phe Ile Lys Pro Glu Asn Asp Asn Gln 
                85                  90                  95      


Ile Glu Leu Lys Met Leu Ile Leu Ile Gly Asn Leu Leu Ser Gln Glu 
            100                 105                 110         


Arg Asn Tyr Tyr Ser His His Phe His Lys Pro Ile Ile Leu Asn Tyr 
        115                 120                 125             


Asp Lys Asp Arg Lys Ser Asp Ser Val Ile Asn Lys Leu Thr Asp Leu 
    130                 135                 140                 


Phe Ala Glu Ala Ile Asp Ser Lys Leu Ser Asn Asn Asp Asn Gly Phe 
145                 150                 155                 160 


Thr Lys Asp Asp Met Ser His Leu Ile Leu Asn Asp Asp Arg Lys Glu 
                165                 170                 175     


Glu Thr Met Pro Gln Trp Leu Asn Pro Tyr Ile Ser Lys Thr Glu Pro 
            180                 185                 190         


Glu Val Thr Glu Tyr Ala Leu Phe Phe Lys Ser Glu Asn Gly Phe Glu 
        195                 200                 205             


Leu Ser Lys Arg Gly Ala Ile Phe Leu Ala Ser Leu Phe Leu Asp Lys 
    210                 215                 220                 


Lys Glu Ala Thr Glu Ile Leu Gly Gly Met Ile Gly Phe Lys Lys Thr 
225                 230                 235                 240 


Asp Gly Asn Lys Phe Arg Leu Thr Arg Glu Val Phe Thr Tyr Tyr Cys 
                245                 250                 255     


Gly Lys Val Val Tyr Asp Arg Lys Asp Thr Lys Asn Ala Asn Val Ser 
            260                 265                 270         


Leu Phe Phe Thr Met Val Ser Tyr Leu Asp Lys Lys Pro Leu Glu Ile 
        275                 280                 285             


Pro Ala Lys Glu Gly Glu Glu Thr Arg Val Arg Asp Leu Phe Gly Tyr 
    290                 295                 300                 


Phe Ala Thr Arg Tyr Leu Leu Met Asp Asn Ser Asp Phe Lys Ile Arg 
305                 310                 315                 320 


Gln Phe Thr Gly Lys Leu Leu Pro Lys Glu Arg Glu Val Lys Ile Lys 
                325                 330                 335     


Asn Asp Lys Ile Ile Pro Val Ser Asp Ser Thr His Glu Lys Ile Tyr 
            340                 345                 350         


Ser Glu His Leu Gln Gln Lys Phe Ala Leu Thr Gly Asn Asn Ile Tyr 
        355                 360                 365             


Phe Glu Tyr Asn Asn Glu Lys Gly Val Leu Gly Phe Lys Ala Leu Ser 
    370                 375                 380                 


Gln Leu Val Phe Ala Lys Leu Leu Arg Asn Glu Ser Gly Phe Glu Asn 
385                 390                 395                 400 


Leu Tyr Gly Asp Val Lys Lys Lys Met Ile Gly Tyr Val Lys Gln Tyr 
                405                 410                 415     


Arg Ala Ile Met Glu Gln Ile Lys Ile Asn Thr Ile Lys Asp Asp Glu 
            420                 425                 430         


Ser Leu Lys Lys Tyr Leu Asp Gly Lys Leu Ile Lys Ile Asn Glu Ile 
        435                 440                 445             


Pro Leu Ala Ile Arg Asn Ser Phe Ser Gly Gly Lys Glu Asp Asp Lys 
    450                 455                 460                 


Ile Phe Thr Asp Arg Val Leu His Arg Leu Lys Asn Lys Ile Lys Glu 
465                 470                 475                 480 


Cys Asp Glu Lys Leu Glu Lys Leu Asn Phe Asn Glu Lys Glu Ile Arg 
                485                 490                 495     


Ile Tyr Asp Ile Val Thr Phe Met Leu Gln Asp Tyr Met Asn Ser Ile 
            500                 505                 510         


Gly Arg Asn Lys Gln Arg Lys Pro Gly Lys Gly Leu Tyr Glu Arg Leu 
        515                 520                 525             


His Asn Asn Leu Thr Phe Tyr Gly Arg Tyr Arg Gly Lys Leu Ile Asp 
    530                 535                 540                 


Thr Leu Lys Asn Lys Tyr Ala Asp Asp Phe Asn Tyr Ser Ile Leu Ala 
545                 550                 555                 560 


Asn Ala Phe Glu Glu Thr Asp Leu His Arg Ala Tyr Glu Arg Tyr Leu 
                565                 570                 575     


Lys Gly Leu Lys Ile Trp Cys Glu Glu Lys Leu Ala Ile Ile Glu Lys 
            580                 585                 590         


Gly Asp Ser Glu Ser Lys Arg His His Asp Ala Asn Val Leu Ser Phe 
        595                 600                 605             


Lys Leu Gly Leu Arg Gln Lys Ser Phe Glu Ser Lys Ser Ile Lys Lys 
    610                 615                 620                 


His Glu Arg Thr Ser Ser Pro Glu Asp Ile Ser Asp Met Ile Leu Asp 
625                 630                 635                 640 


Lys Pro Ile Pro Ile Pro Asp Asn Phe Ile Ser Gly Ile Ile Arg Asp 
                645                 650                 655     


Lys Ile Asn Leu Thr Lys Asp Gly Lys Lys Ile Glu Gln Leu Asn Thr 
            660                 665                 670         


Leu Ile Asp Ile Tyr Ile Pro Glu Lys Ala Phe Asp Ile Gly Arg Asn 
        675                 680                 685             


Glu Lys Glu Lys Asn Ile Met Leu Pro Asp Phe Tyr Asn Glu Ile Glu 
    690                 695                 700                 


Arg Ile Tyr Thr Lys Lys Glu Ile Lys Lys Ile Arg Leu Leu Arg Thr 
705                 710                 715                 720 


His Asp Lys Leu Ile Arg Leu Met Leu Gly Glu Tyr Ala Lys Gly Phe 
                725                 730                 735     


Phe Lys Glu Arg Val Glu Leu Lys Leu Pro Asp Asp Lys Pro Val Ser 
            740                 745                 750         


Glu Leu Tyr Glu Ser Ile Val Glu Met Lys Phe Leu Glu Asp Lys Lys 
        755                 760                 765             


Ile Lys Phe Pro Phe Lys Lys Tyr Asn Lys Val Lys Arg Leu Leu Tyr 
    770                 775                 780                 


Asp Lys Arg Ile Glu Asn Ile Ile Lys Tyr Asn Ile Asp Ala Ser Val 
785                 790                 795                 800 


Lys Leu Phe Glu Phe Thr Asp Asp Ser Glu Lys Lys Phe Ile Ile Asp 
                805                 810                 815     


Asp Gln Lys Asp Leu Phe Lys Lys Ser Gln Lys Arg Leu Ile Ser Ala 
            820                 825                 830         


Ser Leu Ser Phe Glu Glu Arg Phe Trp Lys Asn Asn Lys Pro Asp Asp 
        835                 840                 845             


Leu Leu Arg Lys Phe Thr Lys Ser Gly Asn Tyr Ile Ser His Asn Asn 
    850                 855                 860                 


Ile Leu Ser Glu Ile Gly Lys Asp Glu Lys Phe Gly Lys Met Arg Gly 
865                 870                 875                 880 


Asn Ala Leu His Asn Asn Val Pro Glu Val Lys Gly Tyr Phe Lys Asp 
                885                 890                 895     


Ala Ile Lys Asp Tyr Asp Lys Leu Leu 
            900                 905 


<210>  2489
<211>  1141
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2489

Met Glu Asn Asn Asn Asn Thr Lys Glu Ser Thr Tyr Thr Leu Asp Asn 
1               5                   10                  15      


Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val Tyr 
            20                  25                  30          


Ile Thr Val Asn His Ile Asn Lys Thr Leu Glu Leu Lys Asn Lys Lys 
        35                  40                  45              


Asp Gln Glu Ile Ile Ile Asp Asn Asp Gln Asp Ile Leu Ala Ile Lys 
    50                  55                  60                  


Thr Leu Trp Glu Asn Val Asn Gly Asp Leu Asn Lys Thr Glu Arg Leu 
65                  70                  75                  80  


Arg Glu Leu Met Thr Lys His Phe Pro Phe Leu Glu Thr Ala Ile Tyr 
                85                  90                  95      


Ser Lys Asn Lys Glu Asp Asn Glu Glu Val Lys Gln Glu Lys Gln Ala 
            100                 105                 110         


Ala Ala Gln Ser Phe Lys Ser Leu Lys His Cys Leu Ile Leu Phe Leu 
        115                 120                 125             


Glu Lys Leu Gln Glu Ala Arg Asn Tyr Tyr Ser His Tyr Lys Tyr Ser 
    130                 135                 140                 


Glu Ser Thr Lys Glu Pro Ile Leu Lys Lys Glu Leu Leu Lys Lys Met 
145                 150                 155                 160 


Tyr Asn Ile Phe Asp Glu Asn Ile Gln Leu Val Lys Lys Asp Tyr Gln 
                165                 170                 175     


His Asn Lys Asp Ile Asn Pro Asp Glu Asp Phe Lys His Leu Asp Arg 
            180                 185                 190         


Thr Glu Glu Glu Phe Asn Tyr Tyr Phe Thr Lys Asp Lys Lys Gly Asn 
        195                 200                 205             


Ile Thr Glu Ser Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys 
    210                 215                 220                 


Lys Asp Ala Ile Trp Met Gln Gln Lys Leu Arg Gly Phe Lys Asp Asn 
225                 230                 235                 240 


Arg Glu Asp Lys Lys Lys Met Thr His Glu Val Phe Cys Arg Arg Arg 
                245                 250                 255     


Met Leu Leu Pro Lys Leu Arg Leu Glu Ser Thr Gln Thr Gln Asp Trp 
            260                 265                 270         


Ile Leu Leu Asp Met Leu Asn Glu Leu Ile Arg Cys Pro Lys Ser Leu 
        275                 280                 285             


Tyr Glu Arg Leu Gln Gly Val Asp Arg Lys Lys Phe Asn Val Pro Phe 
    290                 295                 300                 


Asp Pro Ala Asp Glu Asp Tyr Asp Ala Glu Gln Glu Pro Phe Lys Asn 
305                 310                 315                 320 


Thr Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr 
                325                 330                 335     


Phe Asp Tyr Asn Glu Ile Phe Thr Asn Leu Arg Phe Gln Ile Asp Leu 
            340                 345                 350         


Gly Thr Tyr His Phe Ser Ile Tyr Lys Lys Leu Ile Gly Gly Gln Thr 
        355                 360                 365             


Glu Asp Arg His Leu Thr His Lys Leu Tyr Gly Phe Glu Arg Ile Gln 
    370                 375                 380                 


Glu Phe Ala Lys Gln Asn Arg Pro Asp Lys Trp Lys Ala Ile Val Lys 
385                 390                 395                 400 


Asp Leu Asp Thr Tyr Glu Thr Ser Asn Glu Arg Tyr Ile Ser Glu Thr 
                405                 410                 415     


Thr Pro His Tyr His Leu Glu Asn Gln Lys Ile Gly Ile Arg Phe Arg 
            420                 425                 430         


Asn Gly Asn Asn Asp Ile Trp Pro Ser Leu Glu Thr Asn Gly Glu Asn 
        435                 440                 445             


Asn Glu Lys Ser Lys Tyr Lys Leu Asp Lys Gln Tyr Gln Ala Glu Ala 
    450                 455                 460                 


Phe Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu 
465                 470                 475                 480 


Leu Lys Lys Glu Asp Thr Asp Asn Gly Lys Lys Asn Lys Lys Val Arg 
                485                 490                 495     


Thr Lys Lys Lys Asp Asn Lys Asn Asn Glu Gln Glu Lys His Lys Ile 
            500                 505                 510         


Glu Glu Ile Ile Glu Asn Lys Ile Lys Asp Ile Tyr Thr Leu Tyr Asp 
        515                 520                 525             


Ala Phe Ala Asn Gly Glu Ile Asn Ser Lys Asp Glu Leu Glu Lys Tyr 
    530                 535                 540                 


Cys Lys Gly Lys Asp Ile Glu Ile Val His Leu Pro Lys Gln Met Ile 
545                 550                 555                 560 


Ala Ile Leu Glu Asn Lys Ser Lys Asp Met Ala Lys Lys Ala Lys Arg 
                565                 570                 575     


Lys Gln Lys Glu Met Val Lys Asp Thr Lys Lys Leu Leu Ala Thr Leu 
            580                 585                 590         


Glu Lys Gln Thr Gln Arg Glu Ile Glu Tyr Asp Gly Arg Asn Val Arg 
        595                 600                 605             


Leu Leu Lys Ser Gly Glu Ile Ala Arg Trp Leu Val Asn Asp Met Met 
    610                 615                 620                 


Arg Phe Gln Pro Val Gln Arg Asp Glu Lys Gly Glu Pro Leu Asn Asn 
625                 630                 635                 640 


Ser Lys Ala Asn Ser Thr Glu Tyr Gln Met Leu Gln Arg Ser Leu Ala 
                645                 650                 655     


Leu Tyr Ser Lys Glu Glu Lys Pro Thr Arg Tyr Phe Arg Gln Ile Asn 
            660                 665                 670         


Leu Ile Glu Ser Ser Asn Pro His Pro Phe Leu Lys Trp Thr Lys Trp 
        675                 680                 685             


Glu Glu Cys Asn Asn Ile Leu Ser Phe Tyr His Arg Tyr Leu Thr Lys 
    690                 695                 700                 


Lys Ile Glu Phe Leu Asn Glu Leu Lys Pro Glu Asp Trp Lys Lys Asn 
705                 710                 715                 720 


Gln Tyr Phe Leu Lys Leu Lys Glu Pro Lys Thr Asn Arg Glu Thr Leu 
                725                 730                 735     


Val Gln Gly Trp Lys Asn Gly Phe Asn Leu Pro Arg Gly Ile Phe Thr 
            740                 745                 750         


Glu Pro Ile Arg Asp Trp Phe Lys Arg His Gln Asn Asn Ser Glu Glu 
        755                 760                 765             


Tyr Lys Lys Val Glu Asp Leu Asn Arg Val Gly Leu Val Thr Lys Val 
    770                 775                 780                 


Ile Pro Met Phe Phe Lys Glu Glu Tyr Phe Lys Glu Asp Ala Gln Lys 
785                 790                 795                 800 


Glu Ile Asn Asn Cys Val Gln Pro Phe Tyr Ser Phe Pro Tyr Asn Val 
                805                 810                 815     


Gly Asn Ile His Lys Leu Glu Glu Lys Asn Phe Leu His Arg Glu Glu 
            820                 825                 830         


Arg Arg Glu Leu Trp Gly Glu Lys Lys Asp Lys Phe Lys Gly Tyr Lys 
        835                 840                 845             


Glu Lys Val Lys Ser Lys Lys Leu Thr Asp Lys Glu Lys Glu Glu Tyr 
    850                 855                 860                 


Arg Ser Tyr Leu Glu Phe Gln Ser Trp Asn Lys Phe Glu Arg Glu Leu 
865                 870                 875                 880 


Arg Leu Val Arg Asn Gln Asp Ile Val Thr Trp Leu Leu Cys Thr Glu 
                885                 890                 895     


Leu Ile Asp Lys Leu Lys Val Asp Glu Leu Asn Ile Glu Glu Leu Gln 
            900                 905                 910         


Lys Leu Arg Leu Lys Asp Ile Asp Thr Asp Thr Ala Lys Lys Glu Lys 
        915                 920                 925             


Asn Asn Ile Leu Asn Lys Ile Met Pro Met Gln Leu Pro Val Thr Val 
    930                 935                 940                 


Tyr Glu Val Asp Asp Ser Tyr Lys Ile Val Lys Asp Lys Pro Leu His 
945                 950                 955                 960 


Thr Ile Tyr Ile Glu Glu Lys Glu Thr Lys Leu Leu Lys Gln Gly Asn 
                965                 970                 975     


Phe Lys Ala Leu Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe 
            980                 985                 990         


Val Asp Thr Ser Ser Glu Ala Glu  Ser Lys Ser Asn Pro  Ile Ser Lys 
        995                 1000                 1005             


Leu Arg  Val Glu Tyr Glu Leu  Gly Glu Tyr Gln Asn  Ala Arg Ile 
    1010                 1015                 1020             


Glu Thr  Ile Lys Asp Met Leu  Leu Leu Glu Glu Thr  Leu Ile Asn 
    1025                 1030                 1035             


Lys Tyr  Lys Thr Leu Pro Thr  Asp Lys Phe Ser Asp  Met Leu Asn 
    1040                 1045                 1050             


Ser Trp  Leu Lys Gly Lys Gly  Glu Ala Asp Lys Ala  Arg Phe Gln 
    1055                 1060                 1065             


Asn Asp  Val Lys Leu Leu Thr  Ala Val Arg Asn Ala  Phe Ser His 
    1070                 1075                 1080             


Asn Gln  Tyr Pro Met Arg Asn  Ala Ile Glu Phe Ala  Asn Ile Ile 
    1085                 1090                 1095             


Pro Tyr  Ser Leu Ser Ser Ala  Asn Asn Ser Lys Glu  Lys Gly Leu 
    1100                 1105                 1110             


Ser Ile  Ala Asn Gln Leu Lys  Asp Lys Thr His Lys  Ile Ile Gly 
    1115                 1120                 1125             


Thr Ile  Lys Glu Ile Glu Met  Gln Ile Glu Asn Lys  Lys 
    1130                 1135                 1140     


<210>  2490
<211>  1131
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2490

Met Glu Lys Thr Ile Glu Asn Gln Thr Gln Ser Lys Arg Thr Leu Asn 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Asp Glu Glu Lys Ile Thr Thr Ser Phe Leu Val Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Arg Gln Ser Leu Val Tyr Ser Asn Leu Thr 
65                  70                  75                  80  


Arg Tyr Met His Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Asp 
                85                  90                  95      


Asp Glu Arg Asp Lys Ala Glu Asn Tyr Gly Lys Asp Phe Gly Asn Leu 
            100                 105                 110         


Thr Asp Thr Leu Lys Glu Ile Phe Lys Glu Leu Asn Glu Phe Arg Asn 
        115                 120                 125             


Asp Tyr Ser His Tyr Tyr Ser Thr Glu Lys Lys Asp Lys Arg Lys Thr 
    130                 135                 140                 


Ile Val Ser Asp Lys Leu Lys Asn Phe Leu Asn Ile Asn Tyr Thr Arg 
145                 150                 155                 160 


Ala Ile Lys Tyr Thr Lys Ser Arg Phe Ile Asn Val Phe Ser Asp Asn 
                165                 170                 175     


Asn Phe Cys Leu Ala Glu Glu Ala Lys His Val Glu Asn Asp Asn Thr 
            180                 185                 190         


Ile Thr Gln Asp Gly Ile Val Phe Phe Thr Ser Met Phe Leu Asp Arg 
        195                 200                 205             


Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile Ile Gly Leu Lys Gly Thr 
    210                 215                 220                 


Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Thr Leu Met Ala Phe Cys 
225                 230                 235                 240 


Val Asn Leu Pro His Asp Lys Phe Val Ser Glu Asn Ser Glu Gln Gln 
                245                 250                 255     


Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu 
            260                 265                 270         


Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln His Phe Leu Pro Lys Leu 
        275                 280                 285             


Asp Asp Glu Gln Ile Asp Asn Val Leu Glu Asn Ser Val Pro Tyr Thr 
    290                 295                 300                 


Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn Ile Thr Lys Lys Val Arg 
305                 310                 315                 320 


Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu Lys Phe Ile Asp Gln Lys 
                325                 330                 335     


Lys Leu Phe Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val 
            340                 345                 350         


Leu Asp Glu Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Lys Arg Thr 
        355                 360                 365             


Val Thr Glu Asn Thr Lys Ala Phe Gly Met Leu Gln Asp Leu Asn Asp 
    370                 375                 380                 


Glu Glu Asn Val Leu Asn Lys Ile Asn Thr Gly Glu Ser Lys Ala Lys 
385                 390                 395                 400 


Phe Asp Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Thr Lys Asn 
            420                 425                 430         


Thr Asp Asn Lys Ile Lys Ser Asn Leu Leu Gln Pro Leu Pro Glu Ala 
        435                 440                 445             


Phe Leu Ser Ile Asn Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
    450                 455                 460                 


Glu Gln Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn 
465                 470                 475                 480 


Asn Ser Lys Ile Leu Asn Lys Glu Phe Ile Lys Ala Ile Lys Leu Lys 
                485                 490                 495     


Leu Asn Asp Leu Asp Val Phe Tyr Lys Arg Ser Gln Gly Arg Lys Gln 
            500                 505                 510         


Lys His Ala Tyr Leu Thr Lys Asp Lys Lys Tyr Asp Asn Glu Lys Ile 
        515                 520                 525             


Asn Glu Leu Lys Asn Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu 
    530                 535                 540                 


Tyr Asn Leu Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp 
545                 550                 555                 560 


Leu Asn Ile Ala Asp Val Gln Ala Lys Asn Ala Ile Ser Asp Arg Ile 
                565                 570                 575     


Lys Leu Met Lys Arg Asp Cys Ile Asn Arg Leu Lys Ser Met Lys Lys 
            580                 585                 590         


Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp 
        595                 600                 605             


Ile Val Asp Met Ile Ile Asp Glu Glu Lys Lys Lys Lys Ile Thr Ser 
    610                 615                 620                 


Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Lys 
625                 630                 635                 640 


Glu Lys Lys Glu Leu Phe Ile Leu Ile Cys Asn Asn Glu Leu Lys Leu 
                645                 650                 655     


Asn Asp Asp Asp Gly His Pro Phe Phe Lys Asn Ile Asn Phe Ser Asn 
            660                 665                 670         


Tyr Lys Tyr Thr Ser Glu Ile Tyr Gln Lys Tyr Leu Glu Glu Lys Gly 
        675                 680                 685             


His Lys Met Val Lys Glu Tyr Asn Pro Arg Lys Glu Asn Tyr Val Glu 
    690                 695                 700                 


Lys Asp Lys Ser Trp Leu Glu Ile Asn Phe Tyr Lys Lys Glu Trp Asn 
705                 710                 715                 720 


Glu Asn Ala Lys Lys Asp Leu Thr Val Val Lys Leu Pro Asp Asp Lys 
                725                 730                 735     


Ser Lys Ile Pro Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser 
            740                 745                 750         


Phe Glu Asn Trp Phe Lys Tyr Val Thr Asn Gly Lys Glu Thr Thr Asp 
        755                 760                 765             


Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp Glu Thr Leu 
    770                 775                 780                 


Lys Glu Leu Leu Lys Lys Glu Leu Ser Lys Asn Asn Ile Glu Phe Lys 
785                 790                 795                 800 


Glu Glu Asp Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Asp Lys Cys 
                805                 810                 815     


Arg Asn Asp Lys Thr Gln Lys Phe Tyr Ser Ala Glu Arg Glu Tyr Thr 
            820                 825                 830         


Phe Glu Glu Glu Lys Leu Asn Phe His Ile Asn Thr Lys Ser Lys Phe 
        835                 840                 845             


Glu Glu Tyr Ile Asn Pro Glu Phe Ala Glu Lys Val Phe Arg Leu Lys 
    850                 855                 860                 


Asn Gln Asn Arg Glu Lys Asp Asn Ile Ser Gly Arg Arg Leu Pro Pro 
865                 870                 875                 880 


Leu Lys Met Lys Glu Val Thr Lys Asn Met Val Lys Arg Ile Gly Asn 
                885                 890                 895     


Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Leu Met Leu 
            900                 905                 910         


Leu Met Phe Glu Lys Leu Val Asp Asn Asn Leu Lys Leu Lys Leu Glu 
        915                 920                 925             


Asn Val Asp Lys Leu Leu Asn Glu Ser Ile Glu Ile Asn Gln Ser Ile 
    930                 935                 940                 


Ser Gly Lys Leu Ser Phe Asp Asp Ser Gly Asp Asn Glu Asn Lys Lys 
945                 950                 955                 960 


Asp Arg Ala Ile Ile Cys Arg Asn Ile Thr Glu Thr Arg Lys Arg Lys 
                965                 970                 975     


Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Glu Glu Glu  Asn Ile Pro Ile Glu  Lys Ile Lys 
        995                 1000                 1005             


Ile Glu  Leu Asp Thr Tyr Ser  Lys Ala Lys Asp Val  Val Phe Asp 
    1010                 1015                 1020             


Leu Ile  Phe Asp Leu Glu Arg  Ala Ile Ile Asn Lys  Asp Glu Asn 
    1025                 1030                 1035             


Arg Ile  Lys Glu Leu Asn Lys  Asp Lys Asn Gly Val  Ile Gln Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Phe Trp Leu  Leu Glu Lys 
    1055                 1060                 1065             


Asn Leu  Ile Thr Glu Gln Glu  Phe Thr Phe Met Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Ile  Phe Ser His Asn Gln  Phe Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Leu Phe  Ile Lys Asn Trp Asn  Glu Asn Glu Phe Ala  Lys Gln Ile 
    1100                 1105                 1110             


Leu Asn  Val Tyr Asn Gln Lys  Asn Asn Asn Leu Ile  Lys Ser Ile 
    1115                 1120                 1125             


Lys Asp  Ile 
    1130     


<210>  2491
<211>  1091
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2491

Met Asn Asn Lys His Val Phe Ala Ala Tyr Leu Asn Gln Ala Thr His 
1               5                   10                  15      


Asn Tyr His Leu Leu Leu Asn Asp Ile Ser Gln Lys Ile Gly Lys Thr 
            20                  25                  30          


Met Leu Glu Asp Glu Asn Leu Gln Val His Pro Val Ile Ser Leu Leu 
        35                  40                  45              


Ala Asp Ser Lys Asp Ala Arg Leu Ser Leu Arg Ala Ile Asn Ser Phe 
    50                  55                  60                  


Asn Lys Gly Phe Gly Phe Ile Glu Lys Leu Gln Arg Arg Ile Met Ala 
65                  70                  75                  80  


Tyr Arg Tyr Leu Ser Ala Lys Lys Ser Glu Pro Glu Asp Asn Ala Lys 
                85                  90                  95      


Pro Lys Lys His Ile Lys Lys Ser Gln Glu Tyr Ser Leu Leu Pro Ala 
            100                 105                 110         


Asp Tyr Ala Tyr Gln Leu Lys Ser Leu Ala Ser Thr Leu Asn Asp Glu 
        115                 120                 125             


Arg Asn His Ala Thr His Ala Tyr Leu Gln Pro Val Lys Pro Asp Ala 
    130                 135                 140                 


Asn Leu Ile Glu Phe Leu Tyr Asp Ile Phe Asp Met Ala Val Arg Val 
145                 150                 155                 160 


Cys Lys Ile Arg His Gln Ile Asp Glu Asn Asp Leu Lys His Leu Arg 
                165                 170                 175     


Arg Lys Met Arg Asn Pro Asp Lys Ser Lys Asp Ala Pro Lys Ser Ile 
            180                 185                 190         


Phe Asp Pro Lys Phe Lys Tyr Pro Phe Leu Asp Lys Gln Gly Gln Phe 
        195                 200                 205             


Thr Asp His Gly Arg Ala Phe Leu Thr Cys Leu Phe Leu Asn Lys Gln 
    210                 215                 220                 


Asp Ser Tyr Gln Phe Leu Lys Gln Leu Ser Gly Phe Lys Ser Ser Asn 
225                 230                 235                 240 


Ser Asn Thr His Lys Ala Thr Leu Arg Val Phe Ser Cys Phe Ser Ile 
                245                 250                 255     


Arg Leu Pro Asn Glu Arg Ile Asn Ser Thr Thr Asp Ala Gln Thr Leu 
            260                 265                 270         


Gly Leu Asp Met Leu Asn Glu Leu Ala Arg Cys Pro Ser Leu Leu Phe 
        275                 280                 285             


Pro Val Leu Pro Lys Ile Glu Lys Thr Ile Tyr Glu Ile Pro Val Glu 
    290                 295                 300                 


Val Asn Glu Gln Asn Asn Ser Asp Asp Gly Asn Asp Leu Leu Phe Ile 
305                 310                 315                 320 


Arg His Asp Glu Arg Phe Ile Ser Leu Met Met Arg Tyr Phe Asp Glu 
                325                 330                 335     


Thr Asn Ala Phe Glu Lys Leu Arg Phe His Ile Asp Leu Gly Asp Phe 
            340                 345                 350         


Tyr Phe Ala Ala Tyr Leu Lys Thr Leu Tyr Glu Asp Val Gln Asp Thr 
        355                 360                 365             


Arg Arg Leu Lys Gln Lys Leu His Thr Phe Ala Arg Leu Asn Glu Val 
    370                 375                 380                 


Glu Asn Thr Ala Ile Pro Ala Glu Trp Gln Thr Leu Ile Arg Asp Asn 
385                 390                 395                 400 


Arg Glu Ile Thr Glu Thr Asp Leu Asn Pro Tyr Leu Val Asn Thr Thr 
                405                 410                 415     


Pro His Tyr His Leu Leu Asp Asp Asn Ile Ala Leu Lys Ile Val Gly 
            420                 425                 430         


Pro Asn Thr Val Ile Tyr Pro Lys Leu Thr Pro His Asp Ser Ile Glu 
        435                 440                 445             


Asn Arg Tyr Lys Ser Pro Glu Asn Gln Gln Pro Asp Phe Trp Leu Ser 
    450                 455                 460                 


Lys His Glu Met Leu His Leu Ala Phe Tyr Gln Leu Leu Arg Gln Lys 
465                 470                 475                 480 


His Thr Gln Leu Asn Arg Gly Gln Ile Glu Asp Thr Val Phe Ala Gln 
                485                 490                 495     


Tyr Lys Gln Ala Leu His His Cys Leu Asp Gln Leu Ala Glu Asn Pro 
            500                 505                 510         


Glu Arg Tyr Thr Ser Lys Glu Ala Ile His Asp Leu Ala Gln Gln Tyr 
        515                 520                 525             


Thr Tyr Ser Pro Leu Lys Gln Ala Met Met Leu Asp Glu Ile Pro Lys 
    530                 535                 540                 


Val Val Arg Asp Ala Leu Ile Lys Lys Asp Ser Arg Tyr Gln Asn Ser 
545                 550                 555                 560 


Ala Leu Thr Ala Ile Ser Thr Leu Ile Asn Ile Gly Glu Lys Arg Leu 
                565                 570                 575     


Asp Ala Leu Lys Arg Ser Thr Ser Thr Asp Lys Lys Asp Lys Ser Thr 
            580                 585                 590         


Arg Pro Gly Asp Lys Lys Gln Arg Pro Val Lys Ala Gly Leu Met Gly 
        595                 600                 605             


Glu His Leu Ala Glu Asp Ile Val Arg Phe Gln Pro Ala Gln Asp Asp 
    610                 615                 620                 


Ser Asp Asn Lys Gly Lys Pro Thr Ser Leu Ile Val Ala Glu Leu Gln 
625                 630                 635                 640 


Ala Arg Leu Ala Phe Tyr Gly Arg Asp Lys Ala Gln Leu Pro Ala Leu 
                645                 650                 655     


Cys Lys Ala Met Lys Leu Ile Asp Asn Val Asp Thr Ser Lys Asn His 
            660                 665                 670         


Pro Phe Leu Ala Ala Val Leu Lys Glu Asn His Ala Gly Ile Ile Gly 
        675                 680                 685             


Phe Tyr Gln Ser Tyr Tyr Arg Ala Arg Ala His Tyr Leu Gln Arg Val 
    690                 695                 700                 


Glu Ala Asp Ile Thr Gln Asn Thr Ser His Ile Ser Arg Tyr His Trp 
705                 710                 715                 720 


Leu Lys Thr Pro Thr Arg Asp Lys Pro Asp Phe Ser Ile Lys Ser His 
                725                 730                 735     


Val Lys Lys Leu Lys Ala Gln Pro Val Asn Leu Pro Arg Gly Leu Phe 
            740                 745                 750         


Leu Pro Tyr Ile Lys His Ala Leu Leu Gln Leu Asn His Asp Thr Leu 
        755                 760                 765             


Thr Pro Ala Ile Glu Lys Ser Ala Thr Leu Asn Thr Ser Tyr Leu Ile 
    770                 775                 780                 


Ala Leu Tyr Tyr Gln His Val Leu Gln Asp Lys Pro Gln Ala Val Tyr 
785                 790                 795                 800 


Glu Lys Pro Arg Glu Tyr Lys Ile Ile Ala Gln Thr Phe Asp Asn Arg 
                805                 810                 815     


Thr Asn Gln Phe Lys Pro Leu Pro Ala His Pro Thr Gln Thr Gln Gln 
            820                 825                 830         


Ala Tyr Gly Thr Thr Asn Ala Leu His Thr Lys Ile Lys Gln His Leu 
        835                 840                 845             


Gln Ala Lys Tyr Pro Asp Glu Asp Lys Thr Gln Gln Leu Ala Ala Tyr 
    850                 855                 860                 


Arg Lys Phe Glu Gln Tyr Glu Lys Asn Ile Arg Gln Ile Arg Thr Gln 
865                 870                 875                 880 


Asp Gln Val Leu Phe Leu Ala Cys Gln Gln Leu Leu Ala Leu Asn His 
                885                 890                 895     


Gly Leu Asn Gln Glu Ile Ser Gln Leu Lys Leu His Gln Leu Asp Lys 
            900                 905                 910         


Thr Leu Leu Asp Lys Gln Thr His Tyr Gln Leu His Ile His Gly Lys 
        915                 920                 925             


Thr Ile Ser Gln Ala Gln Ile Arg Ile Lys Lys Ile Gly Glu Phe Arg 
    930                 935                 940                 


Arg Phe Leu Lys Asp Arg Arg Leu Lys Gly Leu Leu Ser Tyr Tyr Gly 
945                 950                 955                 960 


Gln His Asp Ile Pro Arg Glu Val Ile Ala Lys Glu Leu Glu Glu Tyr 
                965                 970                 975     


Gln His Cys Arg Leu Lys Val Phe Glu Arg Leu His Ala Phe Glu Gln 
            980                 985                 990         


Phe Ser Tyr Gln His Phe Gly Leu  Asp Ala Gln Tyr Gln  Gly Ser Glu 
        995                 1000                 1005             


His Gly  Gln Leu Leu Ser Ala  Tyr Phe Lys Ala Asn  Pro Gln Ala 
    1010                 1015                 1020             


Asn His  Glu Ala Gln Met His  Cys Met Leu Val Leu  Arg Asn Ala 
    1025                 1030                 1035             


Phe Ala  His Asn Gln Tyr Pro  Met Pro Gln Ser Lys  Tyr Pro Leu 
    1040                 1045                 1050             


Ala Asn  Ala Met Leu Thr Gln  Ala Gln Gln His Leu  Thr Gln Ser 
    1055                 1060                 1065             


Gly Ala  Pro Gln Val Ala Gln  Tyr Leu Leu Gln Gln  Val Glu Ala 
    1070                 1075                 1080             


Phe Tyr  Pro Asn Pro Ile Thr  Thr 
    1085                 1090     


<210>  2492
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2492

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Ile Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Arg Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2493
<211>  1402
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2493

Met Ala Asn Phe Val Ser Pro Ser Ser Asp Lys His Ile Phe Gly Thr 
1               5                   10                  15      


Tyr Leu Asn Ile Ala His Thr Asn Phe Tyr Arg Thr Ile Leu His Val 
            20                  25                  30          


Phe Ser Ser Ser Gly Ile Asp Cys Tyr Thr Leu Met Gly Asp Leu Phe 
        35                  40                  45              


Val Thr Glu Lys Thr Val Asp Lys Val Ile Asp Ala Phe Trp His Ile 
    50                  55                  60                  


Ala Lys Gln Glu Asn Ile Glu Glu Ala Leu Asp Ser Leu Leu Asp Ile 
65                  70                  75                  80  


Val Lys Lys Cys Tyr Asp Asp Arg Trp Lys Lys Glu Ser Pro Thr Leu 
                85                  90                  95      


Thr Gly Leu Asn Asp His Glu Lys Lys Asn Lys Glu Gly Glu Phe Lys 
            100                 105                 110         


Ala Pro Leu Thr Asp Glu Gly Pro Thr Gly Glu Lys Ala His Leu Met 
        115                 120                 125             


Ala Ala Phe Thr Leu Arg Ser Glu Gln Glu Glu Arg Leu Arg Lys Leu 
    130                 135                 140                 


Leu Phe Arg His Ile Pro Phe Leu Ala Pro Val Met Ala Asp Met Val 
145                 150                 155                 160 


Ala Asp Glu Phe Arg Lys Lys Gln Lys Asn Glu His Asn Glu Asn Asn 
                165                 170                 175     


Ser Ile Met His Asp Ser Ser Leu Thr Asp Cys Leu Gln Ala Leu Ser 
            180                 185                 190         


His Ile Ala Gln Cys Leu Thr Tyr Ser Arg Asn Phe Tyr Thr His Ala 
        195                 200                 205             


Asn Pro Tyr Asn Thr Glu Ala Asp Gln Glu Lys Gln Tyr Asp Ile Gln 
    210                 215                 220                 


Lys Ile Val Ala Gly Tyr Leu Asp Lys Ala Phe Val Ala Ser Arg Arg 
225                 230                 235                 240 


Ile Ala Lys Lys Arg Asn Gly Tyr Ser Glu Gln Asp Leu Lys Phe Leu 
                245                 250                 255     


Thr Asp Lys Val Ser Ala Asn Gly Ser Pro Glu Glu Phe Arg Met Glu 
            260                 265                 270         


Glu Val Phe Val Leu Asp Glu Asn Gly Gln Lys Ile Lys Lys Val Glu 
        275                 280                 285             


Lys Asp Asp Lys Gly Asn Ile Lys Leu Asp Lys Asp Gly Val Pro Ile 
    290                 295                 300                 


Tyr Ile Tyr Lys Lys Lys Val Ile Lys Asp Glu Asn Gly Lys Pro Ile 
305                 310                 315                 320 


Leu Asn Asn Lys Arg Lys Lys Gln Tyr Glu Ile Ile Tyr Glu Asn Gly 
                325                 330                 335     


Ile Pro Val His Glu Tyr Glu Thr Lys Phe Val Glu Arg Lys Asp Trp 
            340                 345                 350         


Tyr Phe Arg Leu Phe Gly Asn Arg Gln Ile Leu Leu Pro Asp Pro Asn 
        355                 360                 365             


Pro Asp Leu Ser Thr Asn Ser Lys Leu Gly Leu Ser Asp Phe Gly Ile 
    370                 375                 380                 


Leu Tyr Phe Cys Ala Leu Phe Leu Ser Lys Glu Gln Leu Ala Gln Phe 
385                 390                 395                 400 


Cys Thr Glu Thr Arg Val Phe Val Asn Ser Pro Phe Gln Asn Asp Asn 
                405                 410                 415     


Asn Lys Lys Asn Asn Ile Ile Leu Asn Met Met Tyr Val Tyr Gln Thr 
            420                 425                 430         


His Ile Pro Arg Gly Lys Arg Leu Asp Ser Glu Arg Asp Ser Gln Ala 
        435                 440                 445             


Leu Ala Met Asp Met Leu Asn Glu Leu Arg Arg Cys Pro Ile Glu Leu 
    450                 455                 460                 


Tyr Asn Val Leu Pro Glu Ile Gly Lys Arg Glu Phe Glu Asp Asn Val 
465                 470                 475                 480 


Gly His Glu Asn Asn Arg Thr Pro Glu Leu Ser Lys Arg Ile Arg Thr 
                485                 490                 495     


Lys Asp Arg Phe Pro His Leu Ala Leu Arg Tyr Ile Asp Ser Gln Lys 
            500                 505                 510         


Thr Phe Glu Lys Ile Arg Phe Gln Val Arg Leu Gly Ser Tyr Arg Phe 
        515                 520                 525             


Cys Phe Tyr Asp Lys Asn Cys Ile Asp Gly Lys Ser His Pro Arg Gln 
    530                 535                 540                 


Leu His Lys Glu Ile Asn Gly Phe Gly Arg Trp Gln Asp Met Glu Lys 
545                 550                 555                 560 


Glu Arg Lys Glu Gln Tyr Gly Pro Leu Phe Gln Lys Thr Arg Asp Val 
                565                 570                 575     


Ser Val Trp Gln Lys Asp Glu Asn Ala Tyr Val Asn Leu Arg Gln Leu 
            580                 585                 590         


Glu Pro Ile Lys Ala Gly Asp Pro Pro His Ile Thr Asp Thr Ile Thr 
        595                 600                 605             


Gln Tyr Asn Ile His Lys Asn Arg Ile Gly Leu Tyr Trp Asn Thr Asp 
    610                 615                 620                 


Glu Glu Thr Tyr Leu Lys Asp Lys Val Gly Glu Asn Gly Glu Thr Ile 
625                 630                 635                 640 


Tyr Lys Gly Tyr Tyr Leu Pro Glu Leu Lys Ala Glu Glu Arg Pro Asn 
                645                 650                 655     


Asp Lys Arg Lys Arg Arg Lys Ala Pro Leu Asp Met Pro Ala Pro Leu 
            660                 665                 670         


Cys Ser Leu Ser Val Tyr Asp Leu Pro Ala Met Leu Phe Tyr Glu His 
        675                 680                 685             


Leu Arg Lys Glu Glu Gln Leu Thr Ala Glu Glu Phe Pro Ser Ile Glu 
    690                 695                 700                 


Asp Ile Ile Ile Lys Gln Tyr Asp Asn Leu Val Arg Phe Phe Lys Gln 
705                 710                 715                 720 


Val Lys Asp Ile Gln Pro Thr Ser Asp Glu Ser Gln Leu Ala Thr Ile 
                725                 730                 735     


Leu Ser Thr Tyr Gly Leu Asn Lys Gln Ser Val Pro Gln Lys Ile Tyr 
            740                 745                 750         


Asp Tyr Leu Ser Met Lys Lys Thr Val Ile Gly Lys Asp Phe Ser Lys 
        755                 760                 765             


Ser Ala Gly Ile Glu Leu Asn Arg Arg Leu Arg Lys Ala Lys Gly Lys 
    770                 775                 780                 


Leu Lys Glu Phe Leu Ala Asp Lys Glu Lys Ile Glu Ser Gly Asn Asn 
785                 790                 795                 800 


Gln Tyr Gly Lys Asp Ser Phe Ala Ser Ile Arg Tyr Val Gln Leu Ala 
                805                 810                 815     


Asn Tyr Leu Ala Glu Ser Ile Met Asp Trp Met Thr Ala Glu Glu Gly 
            820                 825                 830         


Gly Lys Tyr Lys Leu Thr Gly Leu Asn Tyr Arg Val Leu Ala Ser Ser 
        835                 840                 845             


Leu Ala Thr Phe Gly Thr Arg Gln Thr Asp Glu Asp Ile Leu Gln Met 
    850                 855                 860                 


Leu Ala Asp Ala His Ile Tyr Glu Asp Glu Lys Thr Asp His Pro Phe 
865                 870                 875                 880 


Ile Ala Tyr Thr Leu Gly Asp Asp Asp Asn Pro Val Ile Asp Leu Glu 
                885                 890                 895     


Thr Phe Tyr Glu Asn Tyr Leu Asn Arg Glu Ile Lys Gln Ile Glu Lys 
            900                 905                 910         


Tyr Ile Ser Val Thr Ile Asp Ser Gln Thr Asn Lys Glu Val Ile Thr 
        915                 920                 925             


Leu Lys Lys Thr Pro Asp Asn Leu Pro Phe Leu His Arg Gln Arg Lys 
    930                 935                 940                 


Arg Trp Gln Glu Ser Thr Ile Ala Glu Gln Ala Glu Arg Tyr Leu Tyr 
945                 950                 955                 960 


Ile Ala Glu Glu Gly Lys Lys Glu Leu Asn Arg Thr Thr Leu Leu Leu 
                965                 970                 975     


Pro Asp Gly Leu Phe Thr Pro Tyr Ile Ile Lys Val Phe Lys Gln Asn 
            980                 985                 990         


His Pro Asp Leu Ile Cys Gln Met  Gln Ser Leu Ser Asp  Thr Gln Lys 
        995                 1000                 1005             


Lys Gly  Ile Ala Asn Asn Ala  Ala Tyr Leu Ile Asn  Leu Tyr Phe 
    1010                 1015                 1020             


Glu Ser  Lys Gly Glu Lys Ser  Gln Pro Phe Tyr Asp  Ser Thr Glu 
    1025                 1030                 1035             


Pro Phe  Asp Met Asp Met Asp  Asn Arg Ala Lys Thr  Pro Tyr Lys 
    1040                 1045                 1050             


Tyr Ala  Arg Leu Tyr Asp Tyr  Phe Thr Leu Ile Asp  Asp Glu Gln 
    1055                 1060                 1065             


Lys Lys  Arg Tyr Leu Pro Asn  Thr Ile Ile Leu Ser  Lys Ser Lys 
    1070                 1075                 1080             


Asn Arg  Asn Ser Asp Ile Ala  Val Tyr Ile Arg Lys  Ile Lys Glu 
    1085                 1090                 1095             


Lys Gly  Glu Glu Asp Asn Arg  Gln Thr Tyr Arg Lys  Phe Lys Lys 
    1100                 1105                 1110             


Asp Asn  Pro Asp Lys Lys Asp  Glu Trp Asn Lys Glu  Lys Glu Arg 
    1115                 1120                 1125             


Leu Lys  Asn Glu Leu Lys Gln  Lys Val Glu Arg Ala  Gln Lys Lys 
    1130                 1135                 1140             


Ala Lys  Lys Leu Tyr Cys Asp  Met Glu Asp Asn Glu  Arg Ala Ile 
    1145                 1150                 1155             


Arg Arg  His Lys Thr Gln Asp  Arg Ile Leu Phe Leu  Met Ala Lys 
    1160                 1165                 1170             


Asn Ile  Met Gly Asp Thr Val  Asn Gln Asn Gly Asp  Leu Phe Lys 
    1175                 1180                 1185             


Leu Glu  Asn Val Cys Lys Glu  Glu Phe Leu Ser Gln  Lys Val Gln 
    1190                 1195                 1200             


Val Arg  His Ile Val Thr Ser  Gly Asp Arg Gln Ile  Val Ile Gln 
    1205                 1210                 1215             


Lys Asp  Glu Met Pro Ile Lys  Asp Tyr Gly Lys Ile  Tyr Arg Leu 
    1220                 1225                 1230             


Leu Gly  Asp Glu Arg Thr Val  Val Leu Leu Ser Tyr  Met Leu Phe 
    1235                 1240                 1245             


Ala Asn  Asn Gly Ile Ile Asp  Tyr Asp Asn Leu Thr  Glu Glu Leu 
    1250                 1255                 1260             


Lys Gln  Tyr Asp Thr Gln Arg  Ser Ser Ala Ile Lys  Ser Ala Gln 
    1265                 1270                 1275             


Thr Leu  Glu Asn Lys Arg Phe  Val Gln Ala Lys Glu  Val Leu Thr 
    1280                 1285                 1290             


Asp Pro  Glu Lys Asn Glu Phe  Tyr Gln Gly Asn Arg  Arg Tyr Lys 
    1295                 1300                 1305             


Asn Arg  Ala Cys Thr Lys Glu  Asn Asp Ala Lys Arg  Asn Asn Phe 
    1310                 1315                 1320             


Ser Ser  Leu Leu Lys Asp Leu  Gln Lys Leu Thr Pro  Glu Gln Met 
    1325                 1330                 1335             


Glu Met  Phe Cys Asp Glu Asp  Arg Lys Leu Ile Ile  Ala Ile Arg 
    1340                 1345                 1350             


Asn Ala  Phe Ser His Asn Ser  Tyr Pro Ala Trp Glu  Val Ile Gln 
    1355                 1360                 1365             


Lys Leu  Leu Asp Gln Asn Gln  Asp Val Gln Leu Glu  Leu Lys Gln 
    1370                 1375                 1380             


Ile Ala  Gly Phe Leu Ile Asp  Lys Leu Ser Ser Phe  Val Ala Arg 
    1385                 1390                 1395             


Thr Met  Asn Val 
    1400         


<210>  2494
<211>  1162
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2494

Met Glu Thr Ala Glu Asn Leu Lys Ser Tyr Asn Cys Arg Asn Ser Phe 
1               5                   10                  15      


Lys Arg Ile Phe Asp Phe Lys Gly Glu Ile Ala Pro Ile Ala Glu Lys 
            20                  25                  30          


Ala Cys Arg Asn Phe Glu Val Lys Ala Lys Asn Lys Val Asn Arg Glu 
        35                  40                  45              


Gln Arg Leu His Tyr Phe Ala Ile Gly His Thr Phe Lys His Ile Asp 
    50                  55                  60                  


Thr Glu Arg Gln Phe Glu Lys Ala Leu Asn Glu Glu Leu Arg Glu Lys 
65                  70                  75                  80  


Arg Pro Thr Arg Phe Leu Ala Leu Gln Ala Phe Asp Arg Ser Phe Cys 
                85                  90                  95      


Asp Glu Leu Glu Lys Ile Ile Ile Asp Lys Asp Asn Lys Lys Lys Tyr 
            100                 105                 110         


Gln Gly Ile Ile Pro Asp Ile Arg Asn Ile Asn Ser His Tyr Val His 
        115                 120                 125             


Asp Phe Gln Lys Ile Lys Leu Asp Thr Leu Ser Cys Arg Met Ile Ser 
    130                 135                 140                 


Phe Ile Lys Glu Ser Phe Glu Leu Ala Ile Thr Gln Thr Tyr Leu Lys 
145                 150                 155                 160 


Glu Lys Glu Ile Ser Tyr Gln Gln Leu Val Glu Gln Glu Asn Val Asp 
                165                 170                 175     


Lys Ala Leu Val Thr Phe Met His Asp Lys Phe Tyr Pro Leu Asp Asp 
            180                 185                 190         


Lys Gly Thr Asn Leu Pro Glu Glu Val Gln Arg Ser Leu Asp Glu Tyr 
        195                 200                 205             


Lys Ala Ile Arg Asp Asn Phe Lys Ser Leu Ser Lys Glu Asp Ala Ile 
    210                 215                 220                 


Asp Ser Leu Leu Phe Val Glu Val Asp Asn Asp Phe Asp Trp Lys Leu 
225                 230                 235                 240 


Tyr Gly Val His Pro Val Phe Lys Ile Thr Thr Gly Lys Tyr Leu Ser 
                245                 250                 255     


Phe Tyr Ala Cys Leu Phe Leu Leu Ser Met Phe Leu Tyr Lys Ser Glu 
            260                 265                 270         


Ala Glu Lys Leu Ile Gly Lys Ile Lys Gly Phe Lys Lys Gln Glu Lys 
        275                 280                 285             


Thr Glu Glu Lys Ser Lys Arg Arg Ile Phe Ser Phe Phe Ser Lys Lys 
    290                 295                 300                 


Phe Ser Ser Gln Asp Ile Asp Ser Glu Glu Asn His Leu Val Lys Phe 
305                 310                 315                 320 


Arg Asp Leu Ile Gln Tyr Leu Asn His Tyr Pro Leu Ala Trp Asn Lys 
                325                 330                 335     


Glu Leu Glu Leu Glu Ser Gln His Pro Ala Met Thr Asp Lys Leu Lys 
            340                 345                 350         


Ala Lys Ile Ile Glu Met Glu Ile Asn Arg Ser Phe Pro Thr Tyr Ser 
        355                 360                 365             


Asn Asn Glu Arg Phe His Val Phe Ala Lys Tyr Gln Ile Trp Gly Lys 
    370                 375                 380                 


Lys Tyr Phe Gly Lys Ser Ile Glu Gln Glu Tyr Ile Lys Gln Ser Phe 
385                 390                 395                 400 


Thr Glu Lys Glu Ile Glu Ala Phe Asn Tyr Glu Ile Asp Ala Ser Pro 
                405                 410                 415     


Glu Leu Lys Asp Ala Asn Glu Lys Leu Asp Lys Leu Lys Ala Val Thr 
            420                 425                 430         


Gly Leu Tyr Gly Ala Lys Asn Asp Arg Asn Thr Lys Glu Ile Lys Lys 
        435                 440                 445             


Thr Glu Gly Ile Ile Asn Arg Ile Thr Arg Glu Lys Ala Thr Asn Pro 
    450                 455                 460                 


Val Lys Glu Lys Leu Lys Asn Arg Ile Glu Lys Asn Leu Leu Phe Val 
465                 470                 475                 480 


Ser Tyr Gly Arg Asn Gln Asp Arg Phe Met Asn Phe Ala Ile Arg Tyr 
                485                 490                 495     


Leu Ala Glu Thr Lys Tyr Phe Gly Glu Asp Ala Gln Phe Lys Thr Tyr 
            500                 505                 510         


Arg Phe Ser Ser Thr Glu Glu Gln Asp Asp Glu Leu Leu Lys Leu Lys 
        515                 520                 525             


Glu Thr Gln Ser Lys Lys Glu Tyr Asp Lys Leu Lys Phe His Gln Gly 
    530                 535                 540                 


Lys Pro Val His Phe Thr Thr Phe Lys Asp His Leu Glu His Tyr Glu 
545                 550                 555                 560 


Ser Trp Asp Thr Pro Phe Val Ile Glu Asn Asn Ala Val Gln Val Lys 
                565                 570                 575     


Leu Thr Phe Ala Thr Gly Ile Lys Lys Ile Val Ser Val Gln Arg Gly 
            580                 585                 590         


Leu Met Val Tyr Phe Leu Glu Asp Ala Leu Thr Lys Glu Ser Asp Lys 
        595                 600                 605             


Ile Glu Asn Ala Gly Lys Ser Leu Leu Glu Asp Tyr Tyr Ala Phe His 
    610                 615                 620                 


Gln Lys Glu Phe Ser Gln Cys Lys Ser Val Leu Glu Gln Ser Ser Ser 
625                 630                 635                 640 


Ile Ser Ser Lys Glu Lys Thr Ile Phe Lys Lys Leu Leu Pro Lys Arg 
                645                 650                 655     


Leu Leu Tyr His Tyr Ser Pro Ala Val Gln Asn Gly Lys Pro Gln Asn 
            660                 665                 670         


Thr Leu Ser Leu Leu Leu Glu Arg Ala Thr Asn Ala Glu Lys Arg Tyr 
        675                 680                 685             


Asp Asp Leu Leu Thr Lys Ala Lys Ala Glu Gly Asn Phe Asp Asp Phe 
    690                 695                 700                 


Val Lys Arg Asn Lys Gly Lys Gln Phe Lys Leu Gln Phe Val Arg Lys 
705                 710                 715                 720 


Ala Trp His Leu Met Phe Phe Lys Glu Ser Tyr Met Gln Gln Ala Ala 
                725                 730                 735     


Phe Ser Gly His His Lys Arg Phe His Ile Ala Lys Asp Glu Phe Asn 
            740                 745                 750         


Asp Phe Ser Arg Phe Met Phe Ala Phe Asp Glu Val Pro His Tyr Lys 
        755                 760                 765             


Ala Tyr Leu Thr Glu Met Leu Glu Lys Lys Gly Phe Phe Asp Asn Pro 
    770                 775                 780                 


Gly Phe Lys Thr Leu Phe Arg Asp Gly Val Ser Leu Asp Asp Leu Tyr 
785                 790                 795                 800 


Leu Lys Thr Lys Lys Ala Tyr Glu Ala Trp Leu Ser Glu Gln Asp Ile 
                805                 810                 815     


Arg Val Gln Glu Glu Asp Lys Tyr Ala Leu Gly Asn Tyr Glu His Phe 
            820                 825                 830         


Phe Gly Asp Glu Met Phe Tyr Ile Asn Ile Ser His Phe Ile Asn Tyr 
        835                 840                 845             


Leu Asp Ala Lys Ser Arg Leu Lys Arg Asp Glu Gln Gly Leu Met Lys 
    850                 855                 860                 


Phe Thr Ala Leu Glu Asn Val Lys Phe Leu Ile Pro Glu Tyr Tyr Tyr 
865                 870                 875                 880 


Thr Asp Lys Leu Glu Lys Ala Glu Tyr Lys Thr Cys Gly Lys Leu Tyr 
                885                 890                 895     


Asn Lys Leu Lys Ser Ser Lys Leu Glu Asp Ala Leu Leu Phe Glu Met 
            900                 905                 910         


Ala Met Arg Tyr Leu Lys Ile Asp Lys Gln Ile Val Gln Lys Ala Lys 
        915                 920                 925             


Ser His Ala Thr Glu Ile Leu Lys Gln Asp Val Glu Phe Asp Ile Arg 
    930                 935                 940                 


Asp Leu Asn Ser Asn His Leu Tyr His Leu Met Val Pro Phe Asn Lys 
945                 950                 955                 960 


Ile Glu Ser Tyr Ile Gly Leu Ile Lys Leu Lys Glu Glu Gln Glu Glu 
                965                 970                 975     


Ser Lys Phe Lys Thr Ser Phe Leu Ala Asn Ile Val Ser Tyr Ile Glu 
            980                 985                 990         


Leu Val Lys Glu Lys Lys Glu Ile  Lys Gly Ile Tyr Lys  Thr Phe Ser 
        995                 1000                 1005             


Thr Asn  Pro Ala Lys Arg Val  Leu Thr Phe Asp Glu  Leu Asn Lys 
    1010                 1015                 1020             


Ile Asp  Gly His Leu Ile Ser  Ser Ser Val Lys Phe  Thr Lys Leu 
    1025                 1030                 1035             


Ala Leu  Thr Leu Glu Gln Tyr  Tyr Val Ser Glu Arg  Met Leu Ser 
    1040                 1045                 1050             


Ile Ile  Ala Asp His Arg Ile  Glu Tyr Asp Glu Ile  Lys Asp Leu 
    1055                 1060                 1065             


Lys Lys  Tyr Tyr Asn Thr Lys  Thr Arg Asn Lys Ala  Phe His Phe 
    1070                 1075                 1080             


Gly Val  Pro Glu Asn Ser Tyr  Asp Asn Ile Ile Ser  Lys Ile Glu 
    1085                 1090                 1095             


Gln Glu  Phe Val Arg Asn Glu  Ile Lys Ser Thr Gln  Ser His Lys 
    1100                 1105                 1110             


Phe Glu  Glu Leu Ser Lys Pro  Leu Lys Ser Ile Cys  Ser Leu Phe 
    1115                 1120                 1125             


Met Asp  Thr Ile His Asn Asn  Tyr Phe Asp Pro Arg  Glu Arg Asp 
    1130                 1135                 1140             


Gly Lys  Lys Lys His Lys Asp  Ala Glu Gln Lys Tyr  Phe Asp Thr 
    1145                 1150                 1155             


Val Ile  Ser Lys 
    1160         


<210>  2495
<211>  1162
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2495

Met Glu Thr Ala Glu Asn Leu Lys Ser Tyr Asn Cys Arg Asn Ser Phe 
1               5                   10                  15      


Lys Arg Ile Phe Asp Phe Lys Gly Glu Ile Ala Pro Ile Ala Glu Lys 
            20                  25                  30          


Ala Cys Arg Asn Phe Glu Val Lys Ala Lys Asn Lys Val Asn Arg Glu 
        35                  40                  45              


Gln Arg Leu His Tyr Phe Ala Ile Gly His Thr Phe Lys His Ile Asp 
    50                  55                  60                  


Thr Glu Arg Gln Phe Glu Lys Ala Leu Asn Glu Glu Leu Arg Glu Lys 
65                  70                  75                  80  


Arg Pro Thr Arg Phe Leu Ala Leu Gln Ala Phe Asp Arg Ser Phe Cys 
                85                  90                  95      


Asp Glu Leu Glu Lys Ile Ile Ile Asp Lys Asp Asn Lys Lys Lys Tyr 
            100                 105                 110         


Gln Gly Ile Ile Pro Asp Ile Arg Asn Ile Asn Ser His Tyr Val His 
        115                 120                 125             


Asp Phe Gln Lys Ile Lys Leu Asp Thr Leu Ser Cys Arg Met Ile Ser 
    130                 135                 140                 


Phe Ile Lys Glu Ser Phe Glu Leu Ala Ile Thr Gln Thr Tyr Leu Lys 
145                 150                 155                 160 


Glu Lys Glu Ile Ser Tyr Gln Gln Leu Val Glu Gln Glu Asn Val Asp 
                165                 170                 175     


Lys Ala Leu Val Thr Phe Met His Asp Lys Phe Tyr Pro Leu Asp Asp 
            180                 185                 190         


Lys Gly Thr Asn Leu Pro Glu Glu Val Gln Arg Ser Leu Asp Glu Tyr 
        195                 200                 205             


Lys Ala Ile Arg Asp Asn Phe Lys Ser Leu Ser Lys Glu Asp Ala Ile 
    210                 215                 220                 


Asp Ser Leu Leu Phe Val Glu Val Asp Asn Asp Phe Asp Trp Lys Leu 
225                 230                 235                 240 


Tyr Gly Val His Pro Val Phe Lys Ile Thr Thr Gly Lys Tyr Leu Ser 
                245                 250                 255     


Phe Tyr Ala Cys Leu Phe Leu Leu Ser Met Phe Leu Tyr Lys Ser Glu 
            260                 265                 270         


Ala Glu Lys Leu Ile Gly Lys Ile Lys Gly Phe Lys Lys Gln Glu Lys 
        275                 280                 285             


Thr Glu Glu Lys Ser Lys Arg Arg Ile Phe Ser Phe Phe Ser Lys Lys 
    290                 295                 300                 


Phe Ser Ser Gln Asp Ile Asp Ser Glu Glu Asn His Leu Val Lys Phe 
305                 310                 315                 320 


Arg Asp Leu Ile Gln Tyr Leu Asn His Tyr Pro Leu Ala Trp Asn Lys 
                325                 330                 335     


Glu Leu Glu Leu Glu Ser Gln His Pro Ala Met Thr Asp Lys Leu Lys 
            340                 345                 350         


Ala Lys Ile Ile Glu Met Glu Ile Asn Arg Ser Phe Pro Thr Tyr Ser 
        355                 360                 365             


Asn Asn Glu Arg Phe His Val Phe Ala Lys Tyr Gln Ile Trp Gly Lys 
    370                 375                 380                 


Lys Tyr Phe Gly Lys Ser Ile Glu Gln Glu Tyr Ile Lys Gln Ser Phe 
385                 390                 395                 400 


Thr Glu Lys Glu Ile Glu Ala Phe Asn Tyr Glu Ile Asp Ala Ser Pro 
                405                 410                 415     


Glu Leu Lys Asp Ala Asn Glu Lys Leu Asp Lys Leu Lys Ala Val Thr 
            420                 425                 430         


Gly Leu Tyr Gly Ala Lys Asn Asp Arg Asn Thr Lys Glu Ile Lys Lys 
        435                 440                 445             


Thr Glu Gly Ile Ile Asn Arg Ile Thr Arg Glu Lys Ala Thr Asn Pro 
    450                 455                 460                 


Val Lys Glu Lys Leu Lys Asn Arg Ile Glu Lys Asn Leu Leu Phe Val 
465                 470                 475                 480 


Ser Tyr Gly Arg Asn Gln Asp Arg Phe Met Asn Phe Ala Ile Arg Tyr 
                485                 490                 495     


Leu Ala Glu Thr Lys Tyr Phe Gly Glu Asp Ala Gln Phe Lys Thr Tyr 
            500                 505                 510         


Arg Phe Ser Ser Thr Glu Glu Gln Asp Asp Glu Leu Leu Lys Leu Lys 
        515                 520                 525             


Glu Thr Gln Ser Lys Lys Glu Tyr Asp Lys Leu Lys Phe His Gln Gly 
    530                 535                 540                 


Lys Pro Val His Phe Thr Thr Phe Lys Asp His Leu Glu His Tyr Glu 
545                 550                 555                 560 


Ser Trp Asp Thr Pro Phe Val Ile Glu Asn Asn Ala Val Gln Val Lys 
                565                 570                 575     


Leu Thr Phe Ala Thr Gly Ile Lys Lys Ile Val Ser Val Gln Arg Gly 
            580                 585                 590         


Leu Met Val Tyr Phe Leu Glu Asp Ala Leu Thr Lys Glu Ser Asp Lys 
        595                 600                 605             


Ile Glu Asn Ala Gly Lys Ser Leu Leu Glu Asp Tyr Tyr Ala Phe His 
    610                 615                 620                 


Gln Lys Glu Phe Ser Gln Cys Lys Ser Val Leu Glu Gln Ser Ser Ser 
625                 630                 635                 640 


Ile Ser Ser Lys Glu Lys Thr Ile Phe Lys Lys Leu Leu Pro Lys Arg 
                645                 650                 655     


Leu Leu Tyr His Tyr Ser Pro Ala Val Gln Asn Gly Lys Pro Gln Asn 
            660                 665                 670         


Thr Leu Ser Leu Leu Leu Glu Arg Ala Thr Asn Ala Glu Lys Arg Tyr 
        675                 680                 685             


Asp Asp Leu Leu Thr Lys Ala Lys Ala Glu Gly Asn Phe Asp Asp Phe 
    690                 695                 700                 


Val Lys Arg Asn Lys Gly Lys Gln Phe Lys Leu Gln Phe Val Arg Lys 
705                 710                 715                 720 


Ala Trp His Leu Met Phe Phe Lys Glu Ser Tyr Met Gln Gln Ala Ala 
                725                 730                 735     


Phe Ser Gly His His Lys Arg Phe His Ile Ala Lys Asp Glu Phe Asn 
            740                 745                 750         


Asp Phe Ser Arg Phe Met Phe Ala Phe Asp Glu Val Pro His Tyr Lys 
        755                 760                 765             


Ala Tyr Leu Thr Glu Met Leu Glu Lys Lys Gly Phe Phe Asp Asn Pro 
    770                 775                 780                 


Gly Phe Lys Thr Leu Phe Arg Asp Gly Val Ser Leu Asp Asp Leu Tyr 
785                 790                 795                 800 


Leu Lys Thr Lys Lys Ala Tyr Glu Ala Trp Leu Ser Glu Gln Asp Ile 
                805                 810                 815     


Arg Val Gln Glu Glu Asp Lys Tyr Ala Leu Gly Asn Tyr Glu His Phe 
            820                 825                 830         


Phe Gly Asp Glu Met Phe Tyr Ile Asn Ile Ser His Phe Ile Asn Tyr 
        835                 840                 845             


Leu Asp Ala Lys Ser Arg Leu Lys Arg Asp Glu Gln Gly Leu Met Lys 
    850                 855                 860                 


Phe Thr Ala Leu Glu Asn Val Lys Phe Leu Ile Pro Glu Tyr Tyr Tyr 
865                 870                 875                 880 


Thr Asp Lys Leu Glu Lys Ala Glu Tyr Lys Thr Cys Gly Lys Leu Tyr 
                885                 890                 895     


Asn Lys Leu Lys Ser Ser Lys Leu Glu Asp Ala Leu Leu Phe Glu Met 
            900                 905                 910         


Ala Met Arg Tyr Leu Lys Ile Asp Lys Gln Ile Val Gln Lys Ala Lys 
        915                 920                 925             


Ser His Ala Thr Glu Ile Leu Lys Gln Asp Val Glu Phe Asp Ile Arg 
    930                 935                 940                 


Asp Leu Asn Ser Asn His Leu Tyr His Leu Met Val Pro Phe Asn Lys 
945                 950                 955                 960 


Ile Glu Ser Tyr Ile Gly Leu Ile Lys Leu Lys Glu Glu Gln Glu Glu 
                965                 970                 975     


Ser Lys Phe Lys Thr Ser Phe Leu Ala Asn Ile Val Ser Tyr Ile Glu 
            980                 985                 990         


Leu Val Lys Glu Lys Lys Glu Ile  Lys Gly Ile Tyr Lys  Thr Phe Ser 
        995                 1000                 1005             


Thr Asn  Pro Ala Lys Arg Val  Leu Thr Phe Asp Glu  Leu Asn Lys 
    1010                 1015                 1020             


Ile Asp  Gly His Leu Ile Ser  Ser Ser Val Lys Phe  Thr Lys Leu 
    1025                 1030                 1035             


Ala Leu  Thr Leu Glu Gln Tyr  Tyr Val Ser Glu Arg  Met Leu Ser 
    1040                 1045                 1050             


Ile Ile  Ala Asp His Arg Ile  Glu Tyr Asp Glu Ile  Lys Asp Leu 
    1055                 1060                 1065             


Lys Lys  Tyr Tyr Asn Thr Lys  Thr Arg Asn Lys Ala  Phe His Phe 
    1070                 1075                 1080             


Gly Val  Pro Glu Asn Ser Tyr  Asp Asn Ile Ile Ser  Lys Ile Glu 
    1085                 1090                 1095             


Gln Glu  Phe Val Arg Asn Glu  Ile Lys Ser Thr Gln  Ser His Lys 
    1100                 1105                 1110             


Phe Glu  Glu Leu Ser Lys Pro  Leu Lys Ser Ile Cys  Ser Leu Phe 
    1115                 1120                 1125             


Met Asp  Thr Ile His Asn Asn  Tyr Phe Asp Pro Arg  Glu Arg Asp 
    1130                 1135                 1140             


Gly Lys  Lys Lys His Lys Asp  Ala Glu Gln Lys Tyr  Phe Asp Thr 
    1145                 1150                 1155             


Val Ile  Ser Lys 
    1160         


<210>  2496
<211>  1160
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2496

Met Glu Gln Lys Gln Leu Glu Ser Arg Phe Asn Gln Ile Phe Asn Asn 
1               5                   10                  15      


Lys Gly His Thr Gly Pro Ile Ala Glu Lys Ala Val Lys Asn Phe Glu 
            20                  25                  30          


Thr Ile Arg Gln His Lys Val Ser Pro Arg Glu Arg Leu His Tyr Phe 
        35                  40                  45              


Ala Val Gly His Ala Leu Arg Asn Ile Asp Lys Asp Leu Lys Glu Ser 
    50                  55                  60                  


Ile Phe Glu Tyr Asn Leu Asp Glu Glu Gln Lys Lys Gln Lys Pro Thr 
65                  70                  75                  80  


Gln Phe Thr Thr Leu Gln Ser Asp Phe Phe Arg Phe Glu Asn Ala Leu 
                85                  90                  95      


Leu Thr Leu Leu Lys Asp Ile Arg Asn Cys Asn Gly His Tyr Val His 
            100                 105                 110         


Thr Phe Asp Lys Leu Gln Leu Asp Glu Ile Leu Lys Leu Gln Glu Lys 
        115                 120                 125             


Asn Lys Glu His Gly Ile Leu Asn Lys Asp Ala Gly Cys Gln Ile Ile 
    130                 135                 140                 


Glu Phe Leu Lys Glu Ala Phe Glu Phe Ser Ile Leu Ile Gln Phe Leu 
145                 150                 155                 160 


Lys Glu Lys Pro Lys Glu Tyr Glu Lys Phe Lys Lys Arg Lys Asn Glu 
                165                 170                 175     


Asn Lys Asn Gln Ser Leu Arg Asn Leu Ile Gly Gly Tyr Glu Lys Lys 
            180                 185                 190         


Leu Val Lys Tyr Leu Cys Asp Lys Phe Phe Pro Asn Glu Glu Lys Gln 
        195                 200                 205             


Lys Glu Ile Arg Asp Lys Phe Ile Glu His Asn Leu Glu Glu Ala Ile 
    210                 215                 220                 


Glu Asp Leu Leu Phe Ile Pro Val Asp Glu Asp Ile Glu Trp Lys Leu 
225                 230                 235                 240 


Gly Glu Glu His Val Val Phe Val Ile Lys Lys Gly Lys Tyr Leu Ser 
                245                 250                 255     


Phe Tyr Ala Gln Leu Phe Leu Leu Ser Met Phe Leu Tyr Lys Gln Glu 
            260                 265                 270         


Ala Asn Gln Leu Ile Ser Lys Ile Arg Gly Phe Lys Arg Ser Glu Asp 
        275                 280                 285             


Glu Phe Gln Tyr Lys Arg Asn Ile Phe Thr Phe Phe Ser Lys Lys Val 
    290                 295                 300                 


Ser Ser Gln Asp Ile His Ser Glu Glu Lys His Leu Ile Tyr Phe Arg 
305                 310                 315                 320 


Asp Ile Ile Gln Tyr Leu Asn Arg Phe Pro Thr Ala Trp Asn Glu Tyr 
                325                 330                 335     


Leu Ser Pro Glu Arg Lys Asn Leu Pro Met Thr Lys Leu Leu Glu Lys 
            340                 345                 350         


Tyr Ile Leu Glu Glu Glu Ile Phe Arg Thr Phe Ser Thr Tyr Lys Asn 
        355                 360                 365             


Asp Cys Asn Arg Glu Leu Phe Leu Lys Tyr Thr Ile Lys Arg Leu Phe 
    370                 375                 380                 


Arg Lys Lys Ala Glu Leu Phe Asp Ala Glu Lys Ile Ser Ile Asp Asp 
385                 390                 395                 400 


Asn Leu Arg Lys Lys Phe Asn Tyr Glu Ile Asp Thr Ser Pro Glu Leu 
                405                 410                 415     


Lys Asn Ile His Glu Lys Leu Lys Gly Lys Leu Lys Pro Lys Asp Tyr 
            420                 425                 430         


Tyr Lys Asn Ile Lys Arg Lys Glu Glu Leu Glu Lys Glu Glu Asn Pro 
        435                 440                 445             


Glu Lys Leu Lys Leu Ile Lys Lys Val Thr Glu Glu Lys Leu Phe Thr 
    450                 455                 460                 


Ala Tyr Gly Arg Asn Arg Asp Arg Phe Met Asp Phe Ala Val Arg Tyr 
465                 470                 475                 480 


Leu Ala Glu Gln Asn Tyr Phe Gly Lys Asp Ala Glu Phe Lys Met Tyr 
                485                 490                 495     


Met Phe Glu Thr Thr Asn Glu Gln Glu Asn Tyr Leu Lys Glu Gln Lys 
            500                 505                 510         


Asn Thr Ala Asp Lys Lys Val Ile Asp Gln Asn Lys Tyr His Gln Gly 
        515                 520                 525             


Arg Leu Thr Cys Phe Lys Thr Tyr Gln Lys His Lys Asp Asp Tyr Gln 
    530                 535                 540                 


Asn Trp Asp Asp Pro Phe Val Phe Gln Asn Asn Ala Phe Gln Ile Val 
545                 550                 555                 560 


Leu Thr Phe Ser Asn Gly Glu Arg Lys Lys Phe Ser Ile Gln Arg Lys 
                565                 570                 575     


Leu Leu Ile Tyr Leu Leu Glu Asp Ala Leu Phe Asn His Ser Asp Ser 
            580                 585                 590         


Ile Glu Asp Lys Gly Lys Gln Leu Leu Glu Asp Tyr Phe Phe Asn Thr 
        595                 600                 605             


Leu Met Pro Asp Phe Glu Glu Ala Lys Gly Ser Tyr Lys Thr Ser Asp 
    610                 615                 620                 


Asp Val Asn Trp Lys His Arg Lys Leu Leu Pro Lys Arg Leu Ile Tyr 
625                 630                 635                 640 


Thr Val His Pro Pro Arg Arg Thr Asp Ser Glu Glu Gln Ile His Pro 
                645                 650                 655     


Phe Glu Lys Ile Leu Arg Glu Thr Gln Glu Gln Glu Arg Arg Tyr Arg 
            660                 665                 670         


Leu Leu Leu Gly Lys Ala Lys Asn Met Lys Leu Lys Glu Glu Phe Ile 
        675                 680                 685             


Lys Arg Asn Lys Gly Lys His Phe Lys Leu Arg Phe Ile Arg Lys Ala 
    690                 695                 700                 


Trp His Leu Met Tyr Phe Arg Glu Ile Tyr Glu Arg Arg Ala Lys Glu 
705                 710                 715                 720 


His Ser His His Lys Ser Phe His Ile Thr Arg Asp Glu Ile Asn Asp 
                725                 730                 735     


Phe Ser Arg Trp Met Tyr Ala Phe Asp Glu Val Pro Pro Tyr Lys Val 
            740                 745                 750         


Tyr Leu Arg Asn Met Leu Gln Arg Lys Lys Phe Met Glu Asn Glu Glu 
        755                 760                 765             


Phe Ala Glu Leu Phe Glu Lys Gly Lys Ser Leu Asp Glu Phe Tyr His 
    770                 775                 780                 


Leu Thr Lys Gln Glu Phe Ser Lys Arg Ile Lys Asn Asn Leu Phe Gln 
785                 790                 795                 800 


Leu Lys Val Asp Ser Glu Arg Gln Tyr Ala Glu Val Leu Ser Lys Lys 
                805                 810                 815     


Leu Val Tyr Ile Asn Leu Ser His Phe Ile Lys Tyr Leu Asn Ala Lys 
            820                 825                 830         


Gly Lys Leu Thr Val Glu Asn Gly Ile Ile Gln Tyr Lys Ala Ser Thr 
        835                 840                 845             


Asn Lys Lys Tyr Leu Ile Asp Glu Tyr Tyr Tyr Thr Glu Val Leu Pro 
    850                 855                 860                 


Arg Glu Glu Tyr Lys Val His Lys His Leu Phe Asn Lys Leu Arg Ala 
865                 870                 875                 880 


Ala Lys Leu Glu Asp Ala Leu Leu Tyr Glu Leu Ala Met Lys Tyr Leu 
                885                 890                 895     


Lys Glu Asp Glu Glu Ile Val Glu Lys Ala Lys Ser Lys Val Ser Asp 
            900                 905                 910         


Ile Gln Ser Ser Glu Ile Ser Phe Asp Ile Lys Asp Tyr Tyr Gly Asn 
        915                 920                 925             


His Leu Tyr Thr Leu Ile Val Pro Phe Asn Lys Leu Glu Thr Leu Ser 
    930                 935                 940                 


Ile Leu Ile Arg Tyr Lys Thr Gly Gln Glu Asn Glu Leu Lys Asn Lys 
945                 950                 955                 960 


Lys Thr Ser Phe Leu Gly Asn Ile Tyr His Leu Leu Ala Phe Leu Asp 
                965                 970                 975     


Lys Asn Tyr Lys Gln Leu Ser Lys Tyr Lys Asp Asp Gly Gly Phe Lys 
            980                 985                 990         


Lys Ile Val Lys Asn Phe Lys Asn  Lys Lys Arg Leu Ser  Phe Val Glu 
        995                 1000                 1005             


Leu Asn  Thr Ile Asn Gly Tyr  Ile Ile Ser Gly Ala  Val Lys Phe 
    1010                 1015                 1020             


Ser Lys  Val His Met Glu Leu  Glu Arg Tyr Phe Ile  Asn Lys His 
    1025                 1030                 1035             


Lys Ile  Lys Ala Asn His Ile  Tyr Ile Asp Leu Glu  Asp Ile Lys 
    1040                 1045                 1050             


Asp Asp  Ser Asn Lys Gln Val  Phe Gly Asn Tyr Tyr  Asp Ser Lys 
    1055                 1060                 1065             


Leu Arg  Ile Arg Asn Lys Ala  Phe His Phe Gly Val  Pro Thr Asn 
    1070                 1075                 1080             


Phe Phe  Phe Asn Ile Glu Ile  Glu Lys Ile Glu Lys  Lys Phe Ile 
    1085                 1090                 1095             


Leu Glu  Glu Val Lys Leu Gln  Asn Val Ser Ser Phe  Asp Lys Leu 
    1100                 1105                 1110             


Asn Gln  Asn Ala Lys Ser Val  Cys Arg Val Phe Met  Glu Val Leu 
    1115                 1120                 1125             


His Ser  Asp Leu Tyr Arg Arg  Asp Lys Asn Lys Ser  Lys Glu Glu 
    1130                 1135                 1140             


Leu Arg  Arg Glu Phe Glu Glu  Lys Tyr Phe Asn Glu  Ile Ile Thr 
    1145                 1150                 1155             


Thr Val  
    1160 


<210>  2497
<211>  1144
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2497

Met Asn Asn Leu Cys Asn Gln Ser Pro Arg Glu Val Tyr Asn Leu Lys 
1               5                   10                  15      


Asp Ser Pro Trp Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg His Asn 
            20                  25                  30          


Ile Tyr Leu Ile Ser Asn Glu Ile Ser Asp Lys Leu Ser Leu Lys His 
        35                  40                  45              


Pro Leu Ser Asn Glu Glu Ile Ile Glu Lys Ser Phe Leu Thr Asp Lys 
    50                  55                  60                  


Asp Phe Trp Asn Lys Asn Asn Pro Arg Leu Ile Leu Ser Ala Leu Ser 
65                  70                  75                  80  


Arg Phe Met Pro Val Val Lys Thr Tyr Ser Ser Asp Leu Leu His Lys 
                85                  90                  95      


Glu Leu Arg Glu Gln Thr Asp Ile Glu Gly Thr Asp Ile Ala Gly Leu 
            100                 105                 110         


Val Glu Phe Leu Arg Leu Ser Phe Lys Glu Leu Asn Ala Phe Arg Asn 
        115                 120                 125             


Asp Tyr Ser His Tyr Tyr Ser Ser Lys Thr Tyr Asp Lys Arg Lys Val 
    130                 135                 140                 


Val Val Ala Glu Asp Phe Ala Ile Met Leu Arg Lys Gln Phe Gln Leu 
145                 150                 155                 160 


Ala Val Ser Ile Ala Arg Lys Arg Phe Glu Gly Val Ile Pro Ser Gln 
                165                 170                 175     


Ser Phe Asp Phe Val Glu Lys Lys Ile Ala Glu Glu Leu Phe Asn Asp 
            180                 185                 190         


Ser Thr Thr Ile Thr Thr Arg Gly Leu Val Phe Phe Thr Cys Leu Phe 
        195                 200                 205             


Leu Asp Lys Glu Asn Ala Phe Gln Phe Phe Asn Arg Val Ser Gly Phe 
    210                 215                 220                 


Lys Asp Thr Arg Thr Tyr Asp Phe Leu Ala Thr Arg Glu Val Phe Thr 
225                 230                 235                 240 


Val Phe Cys Val Lys Leu Pro His Asp Lys Phe Val Ser Glu Asn Pro 
                245                 250                 255     


Gln Gln Ala Leu Gln Leu Asp Ile Leu Asn Tyr Leu Asn Arg Ala Pro 
            260                 265                 270         


Lys Glu Leu Tyr Asn Ser Leu Thr Glu Glu Gly Lys Lys Ile Phe Lys 
        275                 280                 285             


Pro Asp Leu Ser Glu Phe Ala Lys Ile Asn Ile Ala Glu Asn Ser Ile 
    290                 295                 300                 


Asn Glu Thr Ile Ala Asp Tyr Asp Tyr Asp Glu Tyr Ile Gln Ala Ile 
305                 310                 315                 320 


Thr Thr Lys Thr Arg Ser Glu Asp Arg Phe Pro Glu Phe Ala Leu Arg 
                325                 330                 335     


Tyr Leu Asp Gln Ser Asp Ala Phe Gln Tyr His Phe His Ile His Leu 
            340                 345                 350         


Gly Lys Val Ile Thr Asn Lys Tyr Pro Lys Pro Phe Leu Gly Glu Ser 
        355                 360                 365             


Pro Asp Glu Asp Asn Arg Asn Ile Glu Lys Ser Ile Lys Thr Phe Gly 
    370                 375                 380                 


Glu Leu Thr Ala Phe Leu Lys Pro His Gln Thr Asp Thr Glu Gly Val 
385                 390                 395                 400 


Lys Asn Ser Ile Ile Gln Glu Asp Glu Phe Lys Lys Leu Phe Gln Glu 
                405                 410                 415     


Gln Gly Leu Val Gly Phe Thr Gln Tyr Ala Pro His Tyr His Ile Gln 
            420                 425                 430         


Asn Asn Lys Ile Gly Leu Leu Asp Lys Leu Asn Glu Gln Val Ser Lys 
        435                 440                 445             


Leu Pro Cys Asn Leu Tyr Arg Pro Leu Pro Pro Val Ala Phe Leu Ser 
    450                 455                 460                 


Ile His Glu Leu Pro Lys Val Val Leu Leu Glu Ile Leu Ala Lys Gly 
465                 470                 475                 480 


Lys Ala Ser Lys Leu Ile Thr Asp Phe Leu Gln Lys Asn Lys Glu Leu 
                485                 490                 495     


Ile Tyr Asn Arg Asp Phe Ile Glu Asp Ile Lys Lys Gln Leu Asp Phe 
            500                 505                 510         


Lys Pro Leu Gln Lys Leu Phe Phe Asp Glu Lys Ser Pro Lys Leu Val 
        515                 520                 525             


Asn Asn Glu Glu Thr Glu Arg Lys Ile Glu Glu Thr Gln Asn Gln Leu 
    530                 535                 540                 


Lys Gln Ser Ile Pro Glu Lys Gln Lys Val Lys Leu Lys Ser Thr Leu 
545                 550                 555                 560 


Lys Ser Leu Ile Tyr Ala Arg Tyr Val Asn Glu Val Asn Glu Arg Lys 
                565                 570                 575     


Ala Lys Leu Asn Leu Leu Leu Ala Glu Arg Lys Leu Asp Ala Asn Gln 
            580                 585                 590         


Ile Pro Gly Arg Ile Ile Glu Tyr Trp Leu Asn Ile Asp Ser Val Lys 
        595                 600                 605             


Lys Glu His Ser Ile Gln Asn Arg Ile Lys Ala Glu Arg Lys Glu Cys 
    610                 615                 620                 


Lys Asn Arg Ile Lys Asp Leu Asp Lys Gly Lys Ala Pro Lys Ile Gly 
625                 630                 635                 640 


Glu Met Ala Thr Phe Leu Ala Arg Asp Ile Val Lys Leu Val Ile Asn 
                645                 650                 655     


Lys Asp Val Lys Lys Lys Ile Thr Ser Phe Tyr Tyr Asn Leu Leu Gln 
            660                 665                 670         


Glu Cys Leu Ala Leu Tyr Ala Asp Pro Thr Lys Arg Gln Leu Leu Leu 
        675                 680                 685             


Asp Leu Cys Gly Lys Lys Leu Asn Leu Phe Asn Lys Glu Ile Gly His 
    690                 695                 700                 


Pro Phe Leu Ala Asp Ile Asn Phe Gly Glu Ile Thr Lys Thr Lys Asp 
705                 710                 715                 720 


Leu Tyr Arg Lys Tyr Leu Glu Leu Lys Gly Ala Gly Lys Lys Val Glu 
                725                 730                 735     


Lys Lys Tyr Asn Arg Lys Thr Asn Arg Phe Glu Glu Ile Glu Lys Glu 
            740                 745                 750         


Asp Asp Trp Ile Tyr Asn Thr Phe Tyr Phe Val Lys Lys Asp Pro Ile 
        755                 760                 765             


Thr Asn Lys Glu Phe Thr Lys Ile Lys Leu Pro Glu Ser Asn Val Pro 
    770                 775                 780                 


Leu Ser Tyr Leu Arg Phe Asn Gln Asp Lys Thr Ser Phe Asp Phe Trp 
785                 790                 795                 800 


Leu Asn Ser Val Ser Lys Gly Asn Asn Lys Asn Pro Asn Pro Lys Pro 
                805                 810                 815     


Val Asp Leu Pro Thr Asn Leu Phe Asp Asn Val Leu Ile Ser Ile Leu 
            820                 825                 830         


Lys Arg Lys Val Glu Ile Ser Asp Asp Thr Lys Tyr Asn Tyr Ser Lys 
        835                 840                 845             


Leu Leu Ala Leu Trp Leu Lys Glu Thr Gln Pro Tyr Tyr His Leu Lys 
    850                 855                 860                 


Arg Glu Tyr Thr Ile Phe Lys Asp Lys Pro Tyr Gln Thr Ile Val Glu 
865                 870                 875                 880 


Phe Asp Pro Asn Glu Asn Lys Pro Phe Lys Glu Tyr Tyr Ala Asn Ser 
                885                 890                 895     


Val Glu His Ala Phe Arg Lys Arg Lys Arg Glu Glu Lys Arg Ile Gln 
            900                 905                 910         


Lys Arg Gln Ile Ala Thr Val Phe Lys Lys Ala Ile Glu Asp Asn Glu 
        915                 920                 925             


Lys Val Ile Arg Phe Tyr Gln Thr Lys Asp Arg Ile Thr Leu Leu Met 
    930                 935                 940                 


Leu Asn Glu Leu Met Gly Lys Asp Leu Gln Ile Ser Leu Asn Glu Leu 
945                 950                 955                 960 


Ser Pro Asp Ser Asp Lys Ser Pro Leu Glu Ala His Ile Thr Ile Cys 
                965                 970                 975     


Glu Lys Ile His Gly Lys Thr Ile Thr Asp Arg Arg Lys Arg Lys Asp 
            980                 985                 990         


Phe Ser Val Phe Arg Lys Leu Ile  Ser Asp Arg Arg Leu  Lys His Leu 
        995                 1000                 1005             


Phe Asp  Tyr Tyr Ser Ser Glu  Thr Ile Pro Tyr Glu  Val Leu Arg 
    1010                 1015                 1020             


Glu Glu  Leu Asn Asp Tyr Asp  Arg Cys Lys Glu Lys  Val Phe Lys 
    1025                 1030                 1035             


Ala Ala  Phe Asp Leu Glu Lys  Ala Ile Ile Asn Val  Ala Ser Lys 
    1040                 1045                 1050             


Glu Glu  Tyr Gln Lys Ile Val  Glu Asp Gly Thr Lys  Tyr Gly Ala 
    1055                 1060                 1065             


Asn Ile  Gln His Arg Pro Tyr  Leu Asp Trp Leu Thr  Ser His Asn 
    1070                 1075                 1080             


Ala Ile  Ser Lys Ile Glu Glu  Lys Phe Leu Leu Glu  Val Arg Asn 
    1085                 1090                 1095             


Arg Phe  Ser His Asn Glu Tyr  Pro Lys Lys Asp Ile  Val Thr Lys 
    1100                 1105                 1110             


Tyr Ile  Pro His Phe Ala Asn  Ser Thr Ile Ser Ser  Lys Ile Val 
    1115                 1120                 1125             


Ala Thr  Tyr Val Glu Ile Val  Asn Arg Leu Ile Thr  Thr Ile Leu 
    1130                 1135                 1140             


Arg 
    


<210>  2498
<211>  997
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2498

Met Tyr Glu His Arg Lys Pro His Asp Pro Ser Trp Pro Ala Leu Thr 
1               5                   10                  15      


Met Ala Asp Lys Thr Ala Glu Leu Cys Leu Phe Tyr Asn Leu Ala Leu 
            20                  25                  30          


Asn Arg Val Asn Asp Leu Val Arg Lys Tyr Glu Lys Asp Asp Thr Leu 
        35                  40                  45              


His Ile Glu Asp Val Asn Trp Glu Thr Phe Gly Gly Phe Arg Asn Val 
    50                  55                  60                  


Ser Thr Tyr Leu His Leu Gln Val Phe Met Trp Lys Glu Pro Leu Ser 
65                  70                  75                  80  


Ala Ser Phe Thr Thr Leu Ser Thr Ala Asp Lys Lys Arg Ile His Glu 
                85                  90                  95      


Leu Leu Arg Lys Leu Val Asp Leu Arg Asn Tyr Gln Ser His Tyr Tyr 
            100                 105                 110         


His Asp Ala Ser Val Leu Lys Phe Pro Gln Glu Leu Ile Asp Phe Ile 
        115                 120                 125             


Tyr Ser Arg Tyr Ala Asn Ala Arg Asn Ala Leu Glu Leu Lys Tyr Pro 
    130                 135                 140                 


Glu Phe Val Thr Trp Phe His Asp Leu Asn Glu Asp Lys Val Ile Phe 
145                 150                 155                 160 


Lys Asn Ser Lys Gly Glu Glu Arg Glu Asp Val Tyr Arg His Phe Tyr 
                165                 170                 175     


Phe Phe Asn Ala Asn Gly Asn Ile Glu Pro Glu Gly Lys Asn Phe Phe 
            180                 185                 190         


Leu Ser Phe Phe Leu Leu Lys Gly Glu Met Ser Lys Phe Leu Lys Lys 
        195                 200                 205             


Arg Ser Arg Cys Lys Arg Asp Asn Gly Glu Lys Tyr Gln Val Lys Thr 
    210                 215                 220                 


Arg Leu Tyr Thr Tyr Tyr Cys His Arg Asp Gly Ser Asn Arg Phe Phe 
225                 230                 235                 240 


Leu Glu Gly Lys Glu Glu Tyr Met Asp Thr Glu Glu Arg Leu Arg Arg 
                245                 250                 255     


Gln Gly Asn Thr Leu Leu Asn Tyr Leu Lys Ser Arg Pro Leu Val Asp 
            260                 265                 270         


Leu Lys Tyr Leu Pro Pro Ala Pro Pro Pro Gln Leu Leu Ser Lys Lys 
        275                 280                 285             


Glu Val Glu Glu Arg Lys Asn Arg Ala Glu Ser Gln Ala Glu Glu Glu 
    290                 295                 300                 


Lys Thr Tyr Ile Arg Arg Thr Asp Lys Phe Ala Ser Leu Val Val Arg 
305                 310                 315                 320 


Tyr Phe Met Asp Arg Ala Phe Leu Gly Tyr Glu Gln Glu Pro Cys Phe 
                325                 330                 335     


Tyr Trp His Val Lys Ser Leu Asp Leu Glu Glu Val Gln Lys Gln Lys 
            340                 345                 350         


Gln Glu Asn Arg Val Tyr Asp Ala Glu Gly Ala Tyr Tyr Tyr Gln Lys 
        355                 360                 365             


Glu Ser Arg Trp Ser Pro His Phe Val Pro Gly Glu Phe Pro Val Phe 
    370                 375                 380                 


Val Asn Gly His Ile Lys Phe Arg Leu Gly Pro Glu Gly Met Glu Tyr 
385                 390                 395                 400 


Ala Ile Ser Thr Gly Glu Leu Lys Asn Met Leu Tyr Leu Leu Leu Asn 
                405                 410                 415     


Ser Pro Arg Lys Asn Met Thr Glu Ile Gln Asp Ala Leu Leu Arg Tyr 
            420                 425                 430         


Gly Thr Gln Phe Ser Asn Ala Met Arg Glu Leu Thr Thr Glu His Asn 
        435                 440                 445             


Ile Arg Tyr Glu Ala Tyr Pro Leu Val Phe Glu Lys Gly Arg Asp Ser 
    450                 455                 460                 


Val Leu Leu Ser Lys Met His Arg Lys Val Leu Asp Lys Glu Lys Phe 
465                 470                 475                 480 


Asp Ala Ala Ile Tyr Thr Ala Ala Leu Glu Lys Ala Leu Asp Ser Arg 
                485                 490                 495     


Leu Arg Trp Val Glu Tyr Asn Cys Lys Pro Glu Val Tyr Thr Leu Tyr 
            500                 505                 510         


Thr Arg Asn Arg Met Asn Arg Ile Leu Leu Ser Cys Phe Asn Trp Tyr 
        515                 520                 525             


Leu Pro Asp Asp Ala Lys Leu Lys Pro Thr Glu Val Asn Lys Leu Ser 
    530                 535                 540                 


Ile Tyr Asn Phe Val Ser Asp Asn Ser Tyr Thr Ser Asp Ala Thr Arg 
545                 550                 555                 560 


Glu Ser Ile Val Val Gly Ile Gln Gln Lys Leu Asn Arg Ala Gln Phe 
                565                 570                 575     


Gly Ala Phe Ala Leu Leu Arg Thr Ala Ser Gly Leu Gln Asp Ala Tyr 
            580                 585                 590         


Leu Lys Met Leu Gly Lys Leu Arg Asp Ser Leu Leu Val Glu Lys Gln 
        595                 600                 605             


Gln Leu Leu Ala Gly Thr His Gly His Val Leu Lys Leu Gly Ala Arg 
    610                 615                 620                 


Leu Gly Leu Ala Leu Pro Gly Thr Asp Val Ser Arg Asn Gly Thr Asp 
625                 630                 635                 640 


Arg Met Gln Glu Leu Lys Gln Thr Ile Arg Ser Lys Pro Ile Leu Val 
                645                 650                 655     


Arg Asn Gly Phe Phe Lys Gln Tyr Phe Met Pro Glu Glu Pro Ala Ala 
            660                 665                 670         


Ala Arg Arg Asn Ser Ile Ser Ala Arg Leu Trp Lys Asn Arg Leu Leu 
        675                 680                 685             


Thr Gln Asn Leu Val Gln Gly Gln Tyr Lys Leu Gln Asn Gln Ser Glu 
    690                 695                 700                 


Phe Ile Asn His Pro Glu Tyr Gly Leu Ala Asp Ile Ala Pro Asp Ile 
705                 710                 715                 720 


Leu Ala Leu Val Gly Asp His Phe Asp Ala Cys Met Met Glu His Thr 
                725                 730                 735     


Gln Gly Ser Arg Gln Thr Phe Ala Gln Leu Val Asp Arg Phe Glu Ala 
            740                 745                 750         


Leu Tyr Thr Gly Ser Lys Ser Pro Glu Lys Arg Lys Gln Ile Ala Asp 
        755                 760                 765             


Ala Ile Asn Tyr Ser Arg Val Leu Lys Glu Ile Gln Ala Gln Asp Ala 
    770                 775                 780                 


Leu Leu Leu Gln Val Phe Phe Glu Tyr His Asn Arg Lys Leu Pro Leu 
785                 790                 795                 800 


Asn Arg Arg Glu Leu Lys Tyr Lys Pro Leu Ser Thr Leu Phe Glu Glu 
                805                 810                 815     


Glu Tyr Glu Leu Gln Ile Asp Ala Ser Tyr Lys Val Gln Leu Lys Tyr 
            820                 825                 830         


Lys Gln Leu Asp Asp Leu Ser Thr His Trp Asn Arg Thr Lys Ile Glu 
        835                 840                 845             


Gln Leu Phe Lys Asn Glu Ala Tyr Trp Asn Leu Ala Ile Ile Ala Glu 
    850                 855                 860                 


Leu Asp Ala Lys Gly Lys Lys Ser Met Gln Glu Lys Ile Arg Ile Val 
865                 870                 875                 880 


Met Asp Arg Val Trp Asn Asp Ser Tyr His Tyr Ile Lys Ala Phe Leu 
                885                 890                 895     


His Ile Glu Lys Glu Ala Val Glu Ile Gln Lys Lys Glu Gly Ile Pro 
            900                 905                 910         


Ala Thr Glu Leu Ile Ser Arg Ser Gln Ala Ile Arg Ser Pro Gly Leu 
        915                 920                 925             


Pro Arg Ile Glu Gly Lys Val Leu Leu Ser Thr Phe Ala Gly Leu Asp 
    930                 935                 940                 


Glu Gly Lys Ile Asn Arg Phe Ile Gln Leu Arg Asn Ala Ala Phe His 
945                 950                 955                 960 


Ala Gly Ile Pro Glu Glu Cys Val Lys Tyr Glu Lys Val Lys Asp Asp 
                965                 970                 975     


Leu Tyr Ala Ala Thr Gly Val Lys Lys Pro Val Val Lys Pro Lys Lys 
            980                 985                 990         


Tyr Glu Lys Lys Lys 
        995         


<210>  2499
<211>  1146
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2499

Met Cys Glu Pro Val Gln Val Arg Lys Gln Val Thr Tyr His Ser Gly 
1               5                   10                  15      


Asn Trp Gly Asp Lys His Tyr Phe Ala Pro Phe Leu Asn Leu Ser Val 
            20                  25                  30          


Ser Asn Phe Thr Ser Val Met Glu Ala Leu Ala Leu Gln Leu Gly Gln 
        35                  40                  45              


Ala Pro Glu Asn Arg Glu Ala Thr Val Ser Asp Arg Leu Ala Ser Leu 
    50                  55                  60                  


Phe His Lys Gln Leu Ser Thr Ala Asp Trp Lys Lys Arg Ile Lys Leu 
65                  70                  75                  80  


Ile Ser Gln Tyr Phe Pro Val Val Arg Tyr Leu Asn Gly Met Leu Ile 
                85                  90                  95      


Glu Lys Glu Ile Asn Gly Ile Arg Glu Lys Ala Asn Thr Gly Ser Arg 
            100                 105                 110         


Ala Leu Ile Arg Lys Phe Thr Cys Glu Glu Ala Met Arg Thr Ala Phe 
        115                 120                 125             


Ile His Asn Phe Ser Ser Leu Ile Ile Thr Leu Asp Arg Leu Arg Ser 
    130                 135                 140                 


Tyr Tyr Thr Tyr Tyr Arg His Asp Pro Ile Thr Leu His Pro Asp Pro 
145                 150                 155                 160 


His Ser Phe Tyr Arg Leu Met Asp Asp Leu Phe Thr Asp Val Ala Arg 
                165                 170                 175     


Asp Val Phe Val Lys Arg Val Arg Phe Ser Ser Thr Lys Glu Ala Leu 
            180                 185                 190         


Lys Gln Asn Leu Thr Leu Asp Phe Leu Glu Met Val Ser Glu Lys Arg 
        195                 200                 205             


Asp Gln Leu His Arg Lys Asp Gln Gln Leu Gly Ser Thr Lys Thr Pro 
    210                 215                 220                 


Glu Arg Asn Trp Arg Met Leu Ser Asn Ala Val Ile Tyr Asp Ala Phe 
225                 230                 235                 240 


Ser Pro Met Ile Gly Lys Asn Ile Ser Met Gly Ile Ser Ser Ser Pro 
                245                 250                 255     


Tyr Arg Ala Glu Pro Ala Gly Thr Gly Asp Pro Thr Ser Thr Ala Ser 
            260                 265                 270         


Leu Leu Phe Leu Cys Ser Cys Phe Leu Ser Thr His Gln Met Glu Arg 
        275                 280                 285             


Met Lys Gln Gly Val His Met Phe His Ala Lys Gly Asp Asp Asn Asp 
    290                 295                 300                 


Ser Lys Leu Lys Leu Met Ala Leu His Trp Val Tyr Asn His Leu Thr 
305                 310                 315                 320 


Phe Arg Gly Leu Lys Gln Asn Thr Val His His Phe Glu Ser Leu Leu 
                325                 330                 335     


Val Arg Val Met Asp Glu Leu Ser Lys Val Pro Asp Pro Leu Tyr Arg 
            340                 345                 350         


Val Thr Lys Asp Lys Arg Ala Tyr Phe Leu Ala Ile Asn Pro Cys Cys 
        355                 360                 365             


Ala His His Leu Arg Asp Ser Asn Gly Val Asn His Asp Pro Ala Ile 
    370                 375                 380                 


Asp His Thr Val Arg Lys Arg Thr Thr Glu Arg Phe Pro Ser Leu Ala 
385                 390                 395                 400 


Leu Arg Tyr Leu Asp Glu Val Val Gly Phe Lys Asn Leu Arg Phe Gln 
                405                 410                 415     


Val Tyr Val Gly Asp Tyr Ile His Asp Gln Arg Val Lys Thr Arg Asp 
            420                 425                 430         


Leu Ser Gly Arg Gln Ile His Arg Thr Val Lys Glu Arg Val Asn Val 
        435                 440                 445             


Phe Gly Arg Leu Ser Arg Val Ile Lys Ala Lys Arg Asp Leu Phe Cys 
    450                 455                 460                 


Gly Thr Gly Ala Asp Gly Thr Gly Ser Gln Leu Trp Glu Pro Phe Gln 
465                 470                 475                 480 


Glu Pro Gln Tyr Asn Ile Thr Glu Gly Gly Ile Tyr Ile His Leu Lys 
                485                 490                 495     


Leu Glu Lys Leu Gly Tyr Pro Arg Glu Ala Arg Glu Met Ala Gly Arg 
            500                 505                 510         


His Pro Gly Asp Ser Cys Arg Glu Lys Arg Ile Pro Lys Arg Glu Ile 
        515                 520                 525             


Val Ala His Ile Leu Ala Gly Asp Gln Gly Tyr Gln Gly Gln Pro Thr 
    530                 535                 540                 


Ala Leu Leu Ser Leu Asn Glu Leu Pro Ala Leu Leu Tyr Glu Leu Leu 
545                 550                 555                 560 


Val Asn Lys Lys Ser Pro Glu Glu Ile Glu Gln Thr Leu Ala Gly Lys 
                565                 570                 575     


Val Val Ser Gln Tyr Gln Lys Ile Arg Asp Phe Ser Gly Thr Pro Gly 
            580                 585                 590         


Gln Leu Gln Asp Ala Gln Leu Pro Asp Asn Leu Arg Lys Ala Ala Lys 
        595                 600                 605             


Lys Asp Gln Lys Asn Leu Lys Lys Leu Lys Asn His Ile Ala Arg Asp 
    610                 615                 620                 


Trp Gln Ala Val Ile Asp Gln Arg Glu Gln Leu Arg Asp Met Lys Arg 
625                 630                 635                 640 


Gln Tyr Arg Gln Gly Lys Arg Lys Arg Leu Leu Ser Ile Tyr Glu Ile 
                645                 650                 655     


His Asp Met Ala Gln Trp Ile Ala Arg Asp Ile Lys Asn Leu Met Pro 
            660                 665                 670         


Pro Gln Thr Lys Ala Gln Trp Lys Leu Tyr Asp Gln Lys Glu Leu Gln 
        675                 680                 685             


Asn Gly Leu Ala Asn Tyr Gln Ser Gly Arg Leu Glu Val Arg Thr Leu 
    690                 695                 700                 


Leu Glu Ser Lys Trp Asn Met Thr Ser Glu Gly Pro Phe Trp Ser Arg 
705                 710                 715                 720 


Glu Leu Arg Asn Leu Phe Lys Asn Lys Asp Leu Trp Ser Phe Leu Leu 
                725                 730                 735     


Asn Tyr Leu His Leu Lys Ser Ser Val Leu Lys Gln Leu Leu Asp Thr 
            740                 745                 750         


Ile Glu Leu Thr Arg Asn Asn Lys Lys Leu Leu Lys Gln Ala Leu Glu 
        755                 760                 765             


Tyr Ile Phe Ile Leu Tyr Lys Pro Arg Ile Tyr Thr Ile Asn Ser Met 
    770                 775                 780                 


Asp Lys Glu Lys Glu Lys Leu Leu Asn Gln Pro Val Val Leu Pro Arg 
785                 790                 795                 800 


Gly Leu Phe Asp Pro Lys Pro Ser Tyr Ile Lys Gly Thr Ser Leu Glu 
                805                 810                 815     


Asn Asn Pro Gln Arg Phe Ala Ser Trp Leu Val Tyr Leu Arg Lys Glu 
            820                 825                 830         


Ala Lys Thr Asp His Gln Lys Phe Tyr Asp Leu Glu Arg Asp Tyr Thr 
        835                 840                 845             


Lys Ala Tyr Asn Val Ile Trp Asp Lys Lys Lys Tyr Lys His Leu Asn 
    850                 855                 860                 


His Phe Ile Tyr Lys Thr Asp Lys Ala Ile Arg Lys Cys Met Gln Asn 
865                 870                 875                 880 


Asp Val Val Leu Lys Leu Ile Ala Asn Asp Leu Leu Lys Asn Ile Arg 
                885                 890                 895     


His Asn Asn Thr Asp Asn His Pro Val Asn Ile Ser Leu Ser Glu Met 
            900                 905                 910         


Phe Leu Pro Ile Glu Glu Val Asn Thr Leu Lys Gln Lys Ala Trp Ser 
        915                 920                 925             


Gln His Lys Gly Lys Pro Val Asp Ile Lys His Leu Leu Cys Gln Pro 
    930                 935                 940                 


Glu Glu Val Tyr Asn Ile Ser Phe Leu Lys Cys Phe Asp His Ile Cys 
945                 950                 955                 960 


Phe Arg Glu Leu Pro Leu Lys Asp Phe Asp Tyr Ala Gln Lys Leu Ala 
                965                 970                 975     


Gly Glu Asp Arg Val Lys Arg Leu Glu Ser Trp His Asn Arg Pro Trp 
            980                 985                 990         


Thr Leu Arg Glu Leu Glu Glu Glu  Leu Leu Ile Gly Pro  Asp Ala Tyr 
        995                 1000                 1005             


Glu Thr  Ile Gln Gln Tyr Glu  Phe Phe Lys Ile Met  His Asp Leu 
    1010                 1015                 1020             


Glu Arg  Gly Val Phe Leu Asn  Asn Asn His Lys Asp  Ala Phe Ser 
    1025                 1030                 1035             


Ile Gln  Gln Leu Lys His Ser  Phe Thr Ser Leu Ile  Val Asn Gly 
    1040                 1045                 1050             


Val Leu  Lys Asp His Pro Arg  Ile Asn Glu Ser Asp  Tyr Ala Phe 
    1055                 1060                 1065             


Leu Thr  Gly Asn Asn Ala Asp  Val Asp Tyr Asp Leu  Val Arg Asn 
    1070                 1075                 1080             


Ser Lys  Pro Met Val Arg Lys  Ala Phe Phe Leu Leu  Thr Leu His 
    1085                 1090                 1095             


Gly Ala  Phe Ala Val Asn Arg  Leu Pro Gly Lys Pro  Val Phe Glu 
    1100                 1105                 1110             


Leu Met  Ile Glu Asp Tyr Lys  His Leu Asn Thr Ser  Thr Tyr Ser 
    1115                 1120                 1125             


Arg Phe  Leu Met Asn Val Thr  Arg Lys Ile Val Asp  Glu Leu Val 
    1130                 1135                 1140             


Gly Asp  Ala 
    1145     


<210>  2500
<211>  1185
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2500

Met Glu Ile Asn Glu Lys Ile Val Asn Lys Gly Thr Asn Val Tyr Lys 
1               5                   10                  15      


Thr Leu Glu Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala 
            20                  25                  30          


Arg His Asn Ile Phe Leu Ile Ile Asn Gln Leu Thr Glu Val Phe Asp 
        35                  40                  45              


Tyr Leu Lys Ser Asp Glu Gly Ser Lys Phe Ser Val Leu Ser Asp Asp 
    50                  55                  60                  


Glu Gln Ile Thr Ser Pro Lys His Ile Leu Ser Gln Ile Phe Asp Pro 
65                  70                  75                  80  


Ser Ile Lys Lys Phe Glu Gln Glu Arg Val Arg Val Tyr Arg Tyr Leu 
                85                  90                  95      


Val Lys Arg His His Leu Pro Phe Leu Lys Ile Phe Asp Pro Glu Asn 
            100                 105                 110         


Val Asn Leu Lys Asp Asp Tyr Ser Gly Val Asp Tyr His Arg Leu His 
        115                 120                 125             


Arg Phe Ile Leu Leu Ser Leu Lys Leu Leu Asp Asp Leu Arg Asn Ser 
    130                 135                 140                 


Tyr Ser His Tyr Leu Ala Ile Asp Asp Lys Gly Asn Arg Ile Val Asn 
145                 150                 155                 160 


Arg Asn Asn Asp Val Glu Pro Ser Leu Lys Gln Asp Ile Lys Leu Leu 
                165                 170                 175     


Phe Lys Asn Ala Pro Glu Tyr Ser Phe Leu Arg His Gln Glu Thr His 
            180                 185                 190         


Ser Glu Asp Asp Tyr Lys His Leu Glu Lys Tyr Leu Ile Phe Glu Lys 
        195                 200                 205             


Asn Thr Gly Leu Phe Thr Asp Gln Gly Phe Tyr Phe Phe Ile Asn Leu 
    210                 215                 220                 


Phe Leu Glu Arg Asn Gln Ala Val Lys Phe Leu Lys Arg Phe Lys Gly 
225                 230                 235                 240 


Phe Lys Asn Glu Thr Thr Pro Pro Phe Arg Ala Thr Ile Lys Ala Phe 
                245                 250                 255     


Thr Ser Tyr Ala Leu Lys Leu Pro Asp Val Arg Leu Gly Asn Glu Asn 
            260                 265                 270         


Pro Arg Phe Ser Leu Leu Met Asp Met Leu Thr Glu Leu Asn Lys Cys 
        275                 280                 285             


Pro Arg Glu Leu Phe Asn His Leu Thr Glu Lys Asp Lys Lys Glu Phe 
    290                 295                 300                 


Glu Pro Leu Leu Asn Asp Ala Glu Lys Arg Asn Val Ile Leu Asn Ser 
305                 310                 315                 320 


Thr Asn Tyr Glu Ala Ile Ser Asp Asp Glu Ile Asp Gln Thr Ile Asn 
                325                 330                 335     


Glu Leu Ser Ala Leu Lys Arg Tyr Asn Asp Arg Phe Pro Tyr Phe Ala 
            340                 345                 350         


Leu Arg Phe Leu Asp Glu Thr Asp Ala Phe Lys Asn Ile Arg Phe Gln 
        355                 360                 365             


Ile Thr Ile Gly Lys Leu Ile Val Asn Arg Tyr Asp Lys Glu Ile Ala 
    370                 375                 380                 


Gly Val Val Gln Asp Arg Arg Leu Ile Lys Thr Ile His Ala Phe Gly 
385                 390                 395                 400 


Lys Leu Ser Asp Phe Ala Asp Asn Glu Thr Lys Val Leu Ala Ala Leu 
                405                 410                 415     


Lys Lys Asp Ile Pro Gly Asp Asp Ser Ile Arg Phe Glu Gln Phe Ala 
            420                 425                 430         


Pro His Tyr Asn Thr Asn Asn Asn Lys Ile Ala Phe Tyr Ile Phe Asp 
        435                 440                 445             


Pro Asn Asp Asp Lys Leu Lys Tyr Pro Ser Val Phe Glu Asn Lys Ala 
    450                 455                 460                 


Ala Asn Thr Asp Ala His Asn Lys Pro Thr Gly Phe Ile Ser Leu His 
465                 470                 475                 480 


Asp Leu Pro Lys Leu Leu Leu Leu Ala His Leu Val Pro Asn Glu Pro 
                485                 490                 495     


Glu Gln Leu Ile Cys Asp Phe Ile Arg Asn Thr Asn Pro Glu Leu Leu 
            500                 505                 510         


Asp Lys Gln Leu Leu Asp Thr Ile Arg Gln Arg Ala His Tyr Asn Pro 
        515                 520                 525             


Ser Thr Phe Thr Lys Arg Ile Pro Asn Glu Lys Val Leu Ile Gly Lys 
    530                 535                 540                 


Lys Gly Val Gln Tyr Leu Asn Lys Lys Ser Glu Asp Asp Leu Leu Lys 
545                 550                 555                 560 


Glu Leu Asn Val Ser Lys Ala Glu Leu Leu Glu Leu Asp Lys Gln Ser 
                565                 570                 575     


Leu Leu Lys Lys Thr Lys Asn Lys Lys Gln Phe Glu His Ile Ala Gln 
            580                 585                 590         


Ile Lys Tyr Gln His Leu Leu Ser Glu Arg Ile Glu Glu Leu Lys Lys 
        595                 600                 605             


His Leu Pro Gly Asp Leu Lys Phe Asp Met Leu Pro Ala Arg Ile Leu 
    610                 615                 620                 


Asp Tyr Leu Met Lys Ile Glu Asp Ala Asp Thr Val Lys Gln Ile His 
625                 630                 635                 640 


His Lys Ile Lys Ala Ile Arg Asp Glu Ala Lys Gln Leu Thr Lys Glu 
                645                 650                 655     


Ile Glu Lys Pro Gln Ser Glu Arg Gln Ile Lys Leu Gly Glu Leu Val 
            660                 665                 670         


Thr Phe Ile Ala Arg Asp Ile Ile Lys Met Val Val Ser Lys Glu Val 
        675                 680                 685             


Lys Asp Lys Ile Thr Thr Pro Tyr Tyr Asn Lys Leu Gln Asn Lys Ile 
    690                 695                 700                 


Ala Tyr Phe Ser Leu Asn Gln Lys Glu Leu Ile Ala Ile Cys Glu Glu 
705                 710                 715                 720 


Leu Asn Leu Phe Asn Asn Arg Glu Gly His Val Phe Leu Ser Lys Asn 
                725                 730                 735     


Gly Ile Leu Asn Ser Ser Gly Ile Ile Asp Phe Ala Leu Tyr Tyr Leu 
            740                 745                 750         


Lys Ala Lys Asp Arg Trp Ile Glu Ser Thr Leu Leu Lys Lys Gly Lys 
        755                 760                 765             


Thr Gly Gly Tyr Leu Leu Pro His Asp Lys Ser Ile Pro Leu Ser Leu 
    770                 775                 780                 


Gln Lys Ile Asn Thr Glu Val Asn Thr Phe Asp Phe His Gln Trp Leu 
785                 790                 795                 800 


Lys Ala Lys Ser Gln Met Pro Val Asp Leu Pro Arg Ser Leu Phe Asp 
                805                 810                 815     


Glu Gln Leu Gly Lys Ile Leu Lys Gly Arg Leu Thr Thr Lys Gly Val 
            820                 825                 830         


Ser Tyr Asn Glu Gly Asp Thr Phe Ser Val Leu Leu Gly Lys Tyr Leu 
        835                 840                 845             


Asp Asn Asp Ser Gln Ala Phe Tyr His Tyr Thr Arg Ser Tyr Arg Ile 
    850                 855                 860                 


Asn Lys Glu Leu Val Glu Leu Gln Ile Gln Gly Lys Thr Gly Lys Asp 
865                 870                 875                 880 


Leu Lys Ala Lys Tyr Arg Ile Pro Val Glu Lys Asn Glu Lys Leu Ile 
                885                 890                 895     


Arg Phe Thr Gln Thr Lys Asp Arg Ile Leu Lys Leu Leu Cys Asp Gln 
            900                 905                 910         


Leu Leu Thr Leu Asp Asn Thr Ile Gly Leu Gln Gly Gly Phe Asn Leu 
        915                 920                 925             


Thr Asn Ile His Pro Asn Ala Arg Tyr Asn Pro Leu Lys His Pro Ala 
    930                 935                 940                 


Thr Phe Gln Gln Ser Ile Ile Arg Lys Gly Asn Ala Val Tyr Cys Asn 
945                 950                 955                 960 


Ile Ile Ala Lys Asp Thr Glu Asp Gln Ile Lys Ser Val Glu Arg Phe 
                965                 970                 975     


Glu Leu Leu Gln Thr Glu Ala Gln Arg Glu Ala Tyr Pro Asp Gln Lys 
            980                 985                 990         


Trp Tyr Gln Trp Thr Ile Lys Asp  Phe Gly Arg Phe Lys  Arg Phe Val 
        995                 1000                 1005             


Lys Asp  Arg Arg Ile Pro Asp  Leu Thr Ser Tyr Phe  Gln Asn Lys 
    1010                 1015                 1020             


Asp Ile  Pro Phe Asp Leu Leu  Glu Phe Gln Ile Arg  Glu Tyr Asn 
    1025                 1030                 1035             


Lys Tyr  Arg Glu Ala Ile Phe  Asp Ala Ser Phe Lys  Leu Glu Lys 
    1040                 1045                 1050             


His Ile  Ser His Phe Asp Phe  Glu Gly Ile Lys Arg  Leu Glu Leu 
    1055                 1060                 1065             


Asn Asn  Asn Arg Leu Leu Lys  Thr His Arg Pro Lys  Asp Phe His 
    1070                 1075                 1080             


Asp Ile  Gln Phe His Ile Tyr  Leu Glu Trp Leu Asp  Ile Lys His 
    1085                 1090                 1095             


Ile Lys  Tyr Asn Lys Glu Leu  Val Asn Glu Cys Arg  Asn Lys Tyr 
    1100                 1105                 1110             


Ala His  Ser Gln Cys Pro Gln  Leu Lys Glu Ile Pro  Leu Ile Ser 
    1115                 1120                 1125             


Thr Glu  Gln Met Met Asp Phe  Glu Ala His Lys His  Ile Lys Asp 
    1130                 1135                 1140             


Tyr Lys  His Gly Ser Gly Ile  Ser Ile Pro Glu Lys  Ile Cys Ser 
    1145                 1150                 1155             


Leu Tyr  Thr Met Glu Ile Asp  Lys Ile Ile Glu Asn  Ile Asn Arg 
    1160                 1165                 1170             


Leu Gln  Lys Lys Asn Asn Thr  Thr Met Glu Gly Ile  
    1175                 1180                 1185 


<210>  2501
<211>  1254
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2501

Met Gly Asn Tyr Gln Gln Asn Trp Lys Lys Arg Arg Thr Gly Ser Gln 
1               5                   10                  15      


Pro Asn Ala Met Ser Asp Gln Leu Arg Pro Val Phe Ala Ala Tyr Leu 
            20                  25                  30          


Asn Met Ala Arg Ala Asn Leu Tyr Ser Val Leu Arg Tyr Ile Ser Val 
        35                  40                  45              


Gln Cys Gly Leu Glu Val Asn Gln Asn Glu Asp Ser Met His Glu Leu 
    50                  55                  60                  


Pro Ile Ala Lys Phe Ala Ser Asn Lys Arg Pro Glu Val Arg Gln Lys 
65                  70                  75                  80  


Ala Phe Leu Leu Leu Met Arg Asn Ile Pro Ile Leu Gln Gln Met Thr 
                85                  90                  95      


Gln Ser Gly Leu Thr Gln Gly Lys Pro Ala Asp Gly Asp Arg Pro Ala 
            100                 105                 110         


Lys Glu Lys His Leu Ala Val Glu Gln Glu Asp Leu Gln Arg Val Leu 
        115                 120                 125             


Gln Asn Leu Ile Arg Val Val Asn Phe Lys Arg Asn Leu Phe Thr His 
    130                 135                 140                 


Ala Asp His Tyr Asp Thr Asp Glu Glu Ile Glu Lys Glu Leu Gln Arg 
145                 150                 155                 160 


Glu Val Ala Leu Ser Gly Pro Leu Asn Thr Ala Phe Lys Gly Ser Lys 
                165                 170                 175     


Arg Glu Val Lys Arg Ile Phe Cys Tyr Thr Glu Lys Asp Met Asn Phe 
            180                 185                 190         


Val Asp Gln Asp Glu His Met Lys Arg Ile Pro Met Lys Asp Lys Asn 
        195                 200                 205             


Gly Asn Ile Met Gln Asp Glu Lys Gly Lys Asp Met Tyr Ile Phe Val 
    210                 215                 220                 


Glu Arg Ser Asn Trp Tyr Phe Arg Leu Tyr Asp Thr Thr Pro Asp Pro 
225                 230                 235                 240 


Val Thr Glu Met Pro Leu Ala Gln Lys Leu Thr Thr Val Gly Leu Val 
                245                 250                 255     


Phe Ile Leu Cys Lys Leu Leu His Lys Lys Tyr Ala Thr Gln Leu Val 
            260                 265                 270         


Gln Lys Thr Gly Leu Phe Arg Thr Arg Ala Gln Ser Gly Asn Ser Pro 
        275                 280                 285             


Phe Glu Lys Asn Glu Asn Glu Val Met Phe Asn Ile Phe Cys Ala His 
    290                 295                 300                 


Arg Ile Arg Leu Pro Lys Gly Arg Val Glu Ser Thr Val Ser Asn Tyr 
305                 310                 315                 320 


Ala Leu Gly Leu Asp Ile Leu Asn Glu Leu Gln Lys Cys Pro Ser Glu 
                325                 330                 335     


Leu Phe Glu Thr Leu Ser Pro Glu Asp Lys Glu Cys Phe Gln Val Lys 
            340                 345                 350         


Arg Lys Asp Asn Glu Thr Gln Pro Asp Pro Asp Asp Asp Val Asn Leu 
        355                 360                 365             


Phe Arg Arg Tyr Gly Asp Arg Phe Pro Tyr Leu Ala Met Arg Tyr Ile 
    370                 375                 380                 


Asp Ala Met Arg Gly Tyr Gln Asp Asp Tyr Lys Val Leu Glu Asp Ile 
385                 390                 395                 400 


Val Phe Gln Val Ser Leu Gly Lys Tyr Arg Phe Ser Phe Tyr Asn Arg 
                405                 410                 415     


Ala Ser Leu Asp Thr Thr Glu Lys Asp Arg Val Arg Val Leu Gln Lys 
            420                 425                 430         


Glu Ile Asn Gly Phe Gly Pro Ile Asp Lys Met Glu Gln Lys Arg Lys 
        435                 440                 445             


Glu Lys Tyr Lys Thr Ile Ile Arg Pro Ile Ser Asp Asp Pro Lys His 
    450                 455                 460                 


Leu Tyr Asp Ala Asp Thr Ala Glu Thr Gln Pro Tyr Leu Thr Asp Gln 
465                 470                 475                 480 


His Thr Ala Tyr Ala Ile Thr Gly Asn Arg Ile Gly Ile Thr Trp Asn 
                485                 490                 495     


Glu Arg Ile Gln Lys Pro Gln Ser Asn Glu Met Arg Ser Ser Ile Arg 
            500                 505                 510         


Leu Arg Trp Pro Glu Asn Glu Gln Asn Lys Val Ile Asn Ile Glu Lys 
        515                 520                 525             


Leu Asp Asn Asp Asn Cys Phe Leu Pro Asn Leu Pro Val Ser Thr Val 
    530                 535                 540                 


Asn Ile Ala Pro Arg Ala Trp Leu Ser Val His Asp Leu Pro Ala Leu 
545                 550                 555                 560 


Ile Phe Leu Arg Leu Leu Gly Gly Asp Pro Glu Ala Val Ile Lys Asp 
                565                 570                 575     


Thr Tyr Asn Arg Phe Val Leu Leu Leu Asn Ser Ile Lys Asn Gly Gln 
            580                 585                 590         


Leu Lys Pro Gln Asp Asn Lys Glu Lys Leu Leu Ala Ile Leu Ser Ala 
        595                 600                 605             


Glu Pro Tyr Lys Leu Arg Leu Ser Glu Ile Pro Lys Lys Leu Leu Asp 
    610                 615                 620                 


Tyr Leu Ser Ser Lys Gly Pro Lys Thr Gln Asp Glu Ala Asn Gln Ala 
625                 630                 635                 640 


Phe Thr Lys Trp Val Asn Lys Gln Leu Asp Gly Asp Val Gly Ile Ile 
                645                 650                 655     


Glu Lys Leu Arg Ile Arg Ile Glu Gln Phe Lys Gln Asp Leu Asn Val 
            660                 665                 670         


Val Gly Asp Lys Gln Asn Arg Ile Gly Arg Lys Gly Tyr Val Asp Ile 
        675                 680                 685             


Arg Pro Gly Ser Leu Ala Arg Tyr Ile Thr Lys Asp Ile Met Ala Met 
    690                 695                 700                 


Thr Arg Pro Asp Glu Ser Arg Lys Asn Asn Gly Lys Pro Ser Gly Leu 
705                 710                 715                 720 


Asp Phe Gly Val Leu Gln Ala Ala Ile Ala Thr Phe Lys Ala Asp Glu 
                725                 730                 735     


Ile Ala Leu Ala Lys Thr Ser Leu Gly Gly Met Ile Lys Ser Ala Ile 
            740                 745                 750         


Asn Val Asn Asn His Pro Phe Leu Asn Ser Val Leu Ser Gln Gln Val 
        755                 760                 765             


Thr Asp Thr Ile Asp Leu Tyr Ile Lys Tyr Gln Thr Ala Lys Leu Lys 
    770                 775                 780                 


Phe Phe Lys Ser Leu Arg Lys Gly Glu Lys Gly Asn Tyr Lys Asp Gln 
785                 790                 795                 800 


Trp Phe Leu Arg Glu Ala Tyr Arg Asn His Ala Ala Gln Thr Ser Glu 
                805                 810                 815     


Tyr Met Gln Gly Glu Lys Gly Leu Ala Ser Leu Tyr Leu Glu Thr Leu 
            820                 825                 830         


Gln Leu Pro Asp Gly Leu Phe Thr Asp Ala Ile His Lys Gln Leu Leu 
        835                 840                 845             


Asn Asn Glu Lys Thr Lys Asp Asn Val Glu Phe Leu Ala Ala Leu Ala 
    850                 855                 860                 


Asp Arg Glu Lys Thr Gly Gly Val Ser His Leu Ile Asn Leu Tyr Phe 
865                 870                 875                 880 


Glu Lys Val Ile Gly Asp Lys Pro Gln Ser Phe Tyr Arg Glu Met Lys 
                885                 890                 895     


Arg His Tyr Lys Val Ile Asp Trp Glu Met Phe Lys Tyr Asp Asp Glu 
            900                 905                 910         


His Pro Ile Leu Leu Thr Thr Ile Pro Pro Met Ile Tyr Ser Ser Pro 
        915                 920                 925             


Glu Lys Ile Ala Thr Leu Leu Arg Lys Gly Asp Ala Lys Glu Ser Pro 
    930                 935                 940                 


Ile Val Gln Asp Ile Asp Gln Ile Ser Asp Asn Ile Lys Arg Lys Ile 
945                 950                 955                 960 


Ser Lys Lys Trp Glu Ser Lys Pro Arg Tyr Ala Pro Ile Ser Arg Glu 
                965                 970                 975     


Glu Lys Leu Glu Leu Lys Ala Lys Leu Ile His Gln Met Arg Lys Leu 
            980                 985                 990         


Gln Gln Asn Glu Arg Asn Ile Arg  Arg Tyr Arg Asn Gln  Asp Met Leu 
        995                 1000                 1005             


Leu Phe  Glu Met Ala Lys Lys  Ile Leu Leu Ser Gly  Gly Ala Val 
    1010                 1015                 1020             


Ile Lys  Thr Asn Gly Gln Leu  Glu Arg Gly Ile Asp  Gln Phe Lys 
    1025                 1030                 1035             


Leu Gln  Asp Ile Leu Pro Pro  Ala Met Arg Gln Gly  Ser Asp Lys 
    1040                 1045                 1050             


Asp Leu  Leu Glu Gln Lys Val  Glu Phe Arg Leu Thr  Ile Asn Leu 
    1055                 1060                 1065             


Asn Asp  Glu Tyr Gly Lys Pro  Ile Lys Gly Ser Asp  Asp Lys Pro 
    1070                 1075                 1080             


Met Gln  Arg Thr Ile Ser Gln  Pro Glu Ile Lys Ile  Lys Asn Tyr 
    1085                 1090                 1095             


Gly Asp  Phe Tyr Thr Phe Leu  Tyr Asp Ser Arg Ile  Gly Thr Leu 
    1100                 1105                 1110             


Leu Ser  Gln Leu Thr Glu Asn  Gly Asp Ile Lys Arg  Asp Asp Leu 
    1115                 1120                 1125             


Glu Thr  Glu Phe Asp His Tyr  Asp Arg Gln Arg Gln  Glu Val Phe 
    1130                 1135                 1140             


Arg Leu  Leu Gln Lys Ile Glu  Arg Gln Ile Ile Lys  Ser His Pro 
    1145                 1150                 1155             


Ala Leu  Ala Asn Ser Asn Ala  Gly Lys Pro Gly Ser  Glu Phe Tyr 
    1160                 1165                 1170             


Asp Glu  Asn Gly Lys Pro Tyr  Arg Asn Ser Phe Ser  Ser Leu Leu 
    1175                 1180                 1185             


Leu Leu  Cys Lys Gln Tyr Leu  Ser Glu Gly Gly Glu  Pro Thr Asp 
    1190                 1195                 1200             


Val Ser  Asn Leu Leu Thr Glu  Ile Arg Asn Ala Phe  Ser His Asn 
    1205                 1210                 1215             


Arg Tyr  Val Lys Ser Gln Asp  Lys Gln Leu Asp Ile  Arg Thr Leu 
    1220                 1225                 1230             


Ser Leu  Pro Glu Val Ala Asp  His Ile Leu Asn Trp  Leu Arg Asn 
    1235                 1240                 1245             


His Gln  Tyr Lys Asn Glu 
    1250                 


<210>  2502
<211>  1165
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2502

Met Thr Thr Asp Gln Phe Ser Gly Lys Gly Ile Lys Tyr Thr Leu Glu 
1               5                   10                  15      


Asp Lys Phe Phe Trp Ala Ala Val Phe Asn Leu Ala Arg His Asn Ala 
            20                  25                  30          


Phe Ile Thr Ile Asn His Ile Asn Gln Gln Leu Gly Ile Lys Pro Ile 
        35                  40                  45              


Glu Asn Asp Gln Asp Ile Asn Ser Ile Lys Ile Ser Trp Asn Ala Ser 
    50                  55                  60                  


Phe Asp Ser Glu Asn Leu Glu Arg Lys Ala Lys Leu Tyr Ala Leu Ile 
65                  70                  75                  80  


Asn Lys His Phe Pro Phe Leu Ile Ala Ser Ser Tyr Gly Gln Arg Ser 
                85                  90                  95      


Tyr Glu Val Met Ser Ser Ile Pro Ile Gly Lys Asn Gly Arg Thr Arg 
            100                 105                 110         


Leu Lys Ser Asn Val Glu Arg Lys Thr Glu Gln Ala Asp Ser Leu Asp 
        115                 120                 125             


Leu Lys Met Leu Leu Asp Leu Leu Ile Val Phe Ile Glu Lys Leu Arg 
    130                 135                 140                 


Asp Phe Arg Asn Tyr Tyr Ser His Tyr Lys His Ser Lys Gln Asn Ser 
145                 150                 155                 160 


Leu Pro Lys Leu Asp Val Gly Leu Met Asn Arg Leu Tyr Asp Ile Phe 
                165                 170                 175     


Asp Ser Asn Val Arg Met Val Lys Gln Asp His Lys His Asn Thr Lys 
            180                 185                 190         


Ile Asp Pro Arg Lys Asp Phe Asp His Leu Ile Arg Lys Ser Lys Ser 
        195                 200                 205             


Gly Val Asn Pro Lys Phe Lys Ser His Phe Ala Asn Gly Glu Glu Ile 
    210                 215                 220                 


Thr Glu Ala Gly Leu Leu Phe Phe Ala Ser Ile Phe Leu Glu Lys Lys 
225                 230                 235                 240 


Asp Ala Ile Trp Ile Gln Arg Lys Ile Phe Gly Phe Lys Gly Ser Asn 
                245                 250                 255     


Gln Thr Phe Met Gln Met Thr Asn Glu Val Phe Cys Arg Thr Arg Ile 
            260                 265                 270         


Leu Leu Pro Lys Leu Arg Leu Glu Ser Asn Tyr Asp Asn Asp Gln Leu 
        275                 280                 285             


Leu Leu Glu Met Leu Gly Glu Leu Ala Lys Cys Pro Lys Thr Phe Phe 
    290                 295                 300                 


Asp Arg Leu Ser Glu Asn Asp Arg Gln Lys Phe Met Ile Pro Ile Glu 
305                 310                 315                 320 


Ile Tyr Asp Phe Glu Asn Asp Glu Ser Ile Asp Asn Asp Pro Phe Lys 
                325                 330                 335     


Asn Ile Leu Val Arg His His Asn Arg Phe Ser Tyr Phe Ala Leu Arg 
            340                 345                 350         


Tyr Phe Asp Leu Asn Asn Val Phe Lys Asp Leu Arg Phe Gln Ile Asp 
        355                 360                 365             


Leu Gly Asn Tyr His Phe Ser Ile Tyr Asp Lys Lys Ile Gly Asp Gln 
    370                 375                 380                 


Ile Glu Lys Arg His Leu Thr Arg Asn Leu Phe Ser Phe Gly Arg Ile 
385                 390                 395                 400 


Gln Ser Phe Asp Glu Val Asn Leu Pro Leu Glu Trp Lys Asn Leu Val 
                405                 410                 415     


Arg Asp Leu Asp Tyr Tyr Glu Ser Ser Asp Leu Pro Phe Ile Ser Lys 
            420                 425                 430         


Thr Thr Pro His Tyr His Leu Val Ser Asn Lys Ile Gly Leu Lys Phe 
        435                 440                 445             


Ala Asn Tyr Asp Ser Lys Trp Pro Gly Leu Glu Ile Thr Asp Ala His 
    450                 455                 460                 


Glu Arg Lys Ala Lys Tyr Val Tyr Asp Asn Gln Phe Val Ala Asp Gly 
465                 470                 475                 480 


Phe Leu Ser Val Tyr Glu Leu Val Pro Met Met Phe Tyr Tyr Leu Leu 
                485                 490                 495     


Thr Glu Asp Gly Gln Lys Val Glu Gly Val Leu Lys Ser Thr Lys Glu 
            500                 505                 510         


Lys Ala Tyr Lys Ile Phe Glu Glu Phe Gln Glu Tyr Arg Leu Asn Ser 
        515                 520                 525             


Ile Gln Asp Leu Lys Asn Leu Thr Ser Gln Thr Asn Ile His Pro Gly 
    530                 535                 540                 


Gln Leu Pro Lys Arg Leu Ile Asn Ile Leu Asn Asp Thr Glu Lys Asn 
545                 550                 555                 560 


Leu Glu Asn Glu Ala Arg Arg Lys Ile Ser Ile Leu Ile Glu Asn Thr 
                565                 570                 575     


Glu Lys Arg Ile Lys Gln Leu His Glu Gln Thr Asn Gln Lys Ile Arg 
            580                 585                 590         


Ile Gly Lys Pro Asn Asn Gly Leu Leu Lys Pro Gly Lys Ile Ala Asp 
        595                 600                 605             


Trp Leu Ile Lys Asp Leu Met Arg Phe Gln Pro Val Ala Phe Asp Gln 
    610                 615                 620                 


Phe Asn Gln Pro Leu Asn Arg Ser Lys Ala Asn Ser Thr Glu Tyr Gln 
625                 630                 635                 640 


Leu Leu Gln Lys Thr Phe Ala Leu Tyr Gly Ser Glu Lys Asp Arg Leu 
                645                 650                 655     


Pro Ala Tyr Leu Arg Gln Leu Asn Leu Val Gly Ser Asn Asn Pro His 
            660                 665                 670         


Ala Phe Leu Ser Glu Phe Asn Trp Ala Asn Gln Ser Asn Leu Leu Ser 
        675                 680                 685             


Phe Tyr Glu Ala Tyr Leu Thr Ala Arg Leu Ile Phe Leu Gln Lys Leu 
    690                 695                 700                 


Asn Val Glu Lys Trp Met Glu Tyr Gln Tyr Phe Leu Leu Leu Arg Thr 
705                 710                 715                 720 


Lys Lys Thr Asp Arg Asn Lys Leu Val Ala Gly Trp Lys Asn Gly Phe 
                725                 730                 735     


Asn Phe Pro Arg Gly Leu Phe Thr Gln Pro Ile Lys Glu Trp Phe Ala 
            740                 745                 750         


Lys Phe Asp Ser Gly Ile Ser Lys Glu Ile Glu Asn Tyr Glu Ser Thr 
        755                 760                 765             


Gly Leu Ile Ala Arg Val Ile Pro Leu Phe Phe Glu Lys Lys Tyr Asn 
    770                 775                 780                 


Asp Ser Ala Gln Ala Phe Tyr Ser Phe Asp Phe Asn Ile Gly Asn Pro 
785                 790                 795                 800 


Glu Lys Pro Lys Asp Gly Val Phe Leu Ser Lys Ser Gln Arg Glu Asp 
                805                 810                 815     


Leu Trp Lys Ile Thr Lys Ser Lys Leu Arg Leu Asp Lys Asp Ser Pro 
            820                 825                 830         


Asp Leu Glu Asn Thr Ile Ala Lys Ile Glu Lys Ala Phe Glu Asp Ile 
        835                 840                 845             


Asn Tyr Ser Asn Ile Asp Trp Asn Ile Arg Arg Glu Arg Leu His Lys 
    850                 855                 860                 


Leu Ile His Glu Leu Asn Ile Gln Asp Lys Val Leu Pro Glu Leu Glu 
865                 870                 875                 880 


Lys Arg Asn Ser Asn Leu Lys Leu Lys Thr Lys Ile Ser Glu Ala Ala 
                885                 890                 895     


Ser Glu Lys Phe Arg Glu Thr Phe Asn Phe Arg Lys Trp Gln Gly Phe 
            900                 905                 910         


Glu Lys Glu Leu Arg Leu Tyr Lys Asn Gln Asp Met Leu Ile Trp Leu 
        915                 920                 925             


Leu Cys Arg Asn Leu Arg Thr Asp Ser Gln Leu Ile Asn Leu Asn Ile 
    930                 935                 940                 


Asn Asn Leu Tyr Leu Lys Asn Ile Asp Thr Asp Val His Ser Thr Gln 
945                 950                 955                 960 


Ser Leu Asn Ile Leu Asn Arg Val Leu Pro Met Lys Leu Ser Ile Pro 
                965                 970                 975     


Ile Tyr Pro Thr Asp Glu Lys Gly Asn Val Phe Lys Lys Met Thr Pro 
            980                 985                 990         


Thr Val Val Val Gln Ile Glu Glu  Lys Glu Thr Lys Val  Leu Lys His 
        995                 1000                 1005             


Gly Asn  Phe Lys Ala Leu Val  Lys Asp Arg Arg Leu  Asn Asn Leu 
    1010                 1015                 1020             


Phe Thr  Phe Ile Asp Ala Gly  Pro Ala Asp Phe Gly  Asn Phe Ser 
    1025                 1030                 1035             


Ile Ser  Lys Lys Arg Ile Glu  Ala Glu Leu Ala Lys  Tyr Gln Val 
    1040                 1045                 1050             


Ser Arg  Ile Glu Val Phe Lys  Ile Thr Leu Glu Ile  Glu Lys Asn 
    1055                 1060                 1065             


Ile Val  Asp Ala Tyr Pro Asn  Leu Pro Thr Asp Asn  Phe Arg Glu 
    1070                 1075                 1080             


Leu Leu  Gly Glu Trp Leu Asn  Ile Lys Val Asn Gln  Ser Glu Leu 
    1085                 1090                 1095             


Arg Cys  Phe Thr Gln Ile Leu  Val Ser Ile Arg Asn  Ala Phe Ala 
    1100                 1105                 1110             


His Asn  Gln Tyr Pro Arg Tyr  Cys Asp Glu Lys Phe  Gly Ser Ile 
    1115                 1120                 1125             


Asn Arg  Phe Asn Ile Ser Asn  Pro Asn Thr Ala Glu  Ser Asn Gly 
    1130                 1135                 1140             


Leu Asn  Ile Ala Ile Gln Leu  Leu Asp Leu Ala Thr  Thr Ile Lys 
    1145                 1150                 1155             


Ser Leu  Ile Ile Lys Glu Leu  
    1160                 1165 


<210>  2503
<211>  1242
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2503

Met Glu Gln Asn Arg Lys Glu Gly Ser Leu Arg Thr Gln Glu Asp Ile 
1               5                   10                  15      


Gln Tyr Phe Gly Ser Tyr Phe Asn Met Ala Arg His Asn Leu Tyr Leu 
            20                  25                  30          


Ile Thr Asn His Leu Thr Ser Val Phe Ser His Leu Asn Phe Ser Gln 
        35                  40                  45              


Leu Asp Asp Asp Glu Asp Ile Trp Ser Asp Lys Pro Glu Val Asn Glu 
    50                  55                  60                  


Lys Asn Ile Leu Leu Asn Ile Phe Asp Thr Lys Asn Glu Arg Leu Gln 
65                  70                  75                  80  


Asp Glu Arg Ile Arg Val Phe Arg Tyr Leu Met Arg Arg His His Leu 
                85                  90                  95      


Pro Cys Leu Arg Ile Phe Thr Asn Asp Phe Lys Val Leu Glu Thr Thr 
            100                 105                 110         


Gly Asn Thr Ile Lys Lys Asp Glu Leu Glu Val Asp Phe Asp Ala Val 
        115                 120                 125             


His Lys Phe Leu Asn Ile Ala Phe Lys Glu Ile Asn Leu Phe Arg Asn 
    130                 135                 140                 


Ser Tyr Thr His Tyr Leu Ser Ile Asn Glu Glu Gly Lys Arg Leu Lys 
145                 150                 155                 160 


Lys Lys Lys Lys Ile Ser Ser Lys Leu Val Pro Val Leu Asn Ser Leu 
                165                 170                 175     


Phe Ser Tyr Ala Pro Glu Tyr Ser Phe Leu Arg His Asn Ile Asp Lys 
            180                 185                 190         


Ala Asn Lys Asp Val Lys Ile Tyr Lys Glu Glu Val Lys Glu Tyr Tyr 
        195                 200                 205             


Asp Asn Ile Lys Ser Lys Tyr Lys Leu Phe Glu Asn Asp Ser Asn Glu 
    210                 215                 220                 


Leu Thr Asp Gln Gly Met Tyr Phe Phe Ile Thr Leu Phe Leu Glu Arg 
225                 230                 235                 240 


Ala His Gly Ile Lys Phe Leu Lys Arg Phe Arg Gly Phe Lys Asn Glu 
                245                 250                 255     


Thr Thr Pro Pro Phe Lys Ala Thr Ile Gln Ala Phe Thr Thr Tyr Thr 
            260                 265                 270         


Leu Lys Ile Pro Asp Val Arg Leu Asp Asn Asp Ile Pro Glu Gln Thr 
        275                 280                 285             


Met Ile Met Glu Val Leu Asn Glu Leu Asn Lys Cys Pro Glu Glu Leu 
    290                 295                 300                 


Phe Lys Phe Leu Lys Lys Glu Asp Lys Asp Arg Phe Gln Pro Val Ile 
305                 310                 315                 320 


Ser Asp Glu Ser Leu Thr Asn Ile Ile Asn Ser Ser Asn Tyr Glu Glu 
                325                 330                 335     


Ile Ser Asp Glu Asp Ile Asp Arg Leu Ile Lys Glu Asn Ser Val Leu 
            340                 345                 350         


Lys Arg Arg Glu Asp Arg Phe Pro Tyr Phe Ala Leu Gln Tyr Leu Glu 
        355                 360                 365             


Ile Met Ser Lys Leu Lys Asn Ile Arg Phe Gln Ile Tyr Leu Gly Lys 
    370                 375                 380                 


Leu Val Leu Lys Thr Tyr Asp Lys Glu Asn Pro Asn Ile Glu Arg Arg 
385                 390                 395                 400 


Val Ile Thr Asp Ile His Ala Phe Gly Lys Leu Ser Asp Phe Val Gly 
                405                 410                 415     


Lys Glu Ala Glu Val Leu Asp Thr Phe Asn Ser Gln Leu Lys Asp Tyr 
            420                 425                 430         


Gly Tyr Ser Val Ala Trp Asp Gln Tyr Lys Pro Ser Tyr Ala Ile Glu 
        435                 440                 445             


Met Asn Arg Ile Gly Phe Tyr Leu Phe Asn Asp Gln Gly Asp Lys Val 
    450                 455                 460                 


Glu Asn Lys Ile Leu Pro Ser Leu Cys Lys Asn Lys Asn Leu Glu Arg 
465                 470                 475                 480 


Lys Val Glu Ile Lys Val Asn Lys Ile Gln Pro Thr Gly Phe Ile Ser 
                485                 490                 495     


Thr His Met Leu Pro Lys Phe Leu Ile Ser Tyr Leu Met Gly Asp Val 
            500                 505                 510         


Asn Glu Lys Asn Gly Glu Lys Thr Ile Thr His Phe Leu Glu Lys Val 
        515                 520                 525             


Asn Val Ser Ile Leu Asp Gln Asn Ile Ile Asn Gln Ile Lys Ser Glu 
    530                 535                 540                 


Ile Gln Asn Leu Asp Pro Ile Glu Phe Thr Lys Arg Cys Pro Lys Leu 
545                 550                 555                 560 


Ser Ala Ile Lys Asn Val Lys Lys Leu Arg Val Ala Gly Ala Ile Asp 
                565                 570                 575     


Lys Lys Ile Val Glu Tyr Gln Tyr Ile Asn Asp Thr Asp Ile Ala Lys 
            580                 585                 590         


Leu Val Gln Lys Thr Gly Leu Ala Tyr Asp Thr Met Val Thr Tyr Ser 
        595                 600                 605             


Lys Asp Lys Phe Lys Glu Lys Thr Asn His Leu Asn Leu Ser Lys Lys 
    610                 615                 620                 


Glu Leu Glu Thr Phe Ala His Ile Lys Tyr Lys Tyr Tyr Leu Ser Glu 
625                 630                 635                 640 


Arg Arg Lys Ala Leu Asp Ser Val Leu Lys Ala Tyr Phe Pro Glu Ile 
                645                 650                 655     


Gly Ser Gln Asp Ile Pro Lys Glu Leu Tyr Asn Tyr Leu Leu Asn Ile 
            660                 665                 670         


Asn Glu Gln Asp Asn Lys Lys Leu Glu His Arg Arg Ile Lys Asp Glu 
        675                 680                 685             


Val Thr Lys Thr Lys Lys Leu Ile Lys Asp Val Asn Arg Ser Leu Lys 
    690                 695                 700                 


Phe Glu Asp Lys Ile Leu Leu Gly Asp Leu Ala Thr Lys Ile Ala Arg 
705                 710                 715                 720 


Asp Ile Ile Asn Met Ile Ile Asp Lys Asp Leu Lys Val Ser Met Thr 
                725                 730                 735     


Asn Pro Phe Ala Asn Arg Leu Gln Asn Leu Ile Ala Tyr Phe Ser Thr 
            740                 745                 750         


Asn Lys Glu Ala Ile Val Ala Leu Cys Glu Ser Tyr Lys Val Phe Glu 
        755                 760                 765             


His Asn Lys Gly His Phe Phe Leu Thr Arg Glu Leu Ile Leu Asn Ser 
    770                 775                 780                 


Thr Gly Val Ile Asp Phe Tyr Ile Arg Tyr Phe Glu Ala Lys Ile Glu 
785                 790                 795                 800 


Lys Ile Lys Glu Val Leu Leu Val Arg Gly Lys Glu Gly Gly Tyr Glu 
                805                 810                 815     


Ile Asn Thr Glu Leu Ile Pro Tyr Ser Tyr Thr Gln Tyr Leu Pro Lys 
            820                 825                 830         


Glu Val Lys Glu Glu Asn Lys Asn Thr Cys Lys Asn Leu Phe Glu Gln 
        835                 840                 845             


Trp Leu Tyr Tyr Lys Gln Lys Ser Pro Val Asn Leu Pro Val Thr Leu 
    850                 855                 860                 


Leu Asp Glu Asp Leu Thr Ser Ala Leu Lys Ser Lys Leu Lys Leu Lys 
865                 870                 875                 880 


Pro Asp Leu Lys Asp Gly Phe Ser Lys Leu Ile Gln Leu Tyr Leu Lys 
                885                 890                 895     


Asp Asp Ala Gln Glu Phe Tyr Ser Phe Asp Arg Val Tyr Arg Asn Asn 
            900                 905                 910         


Asp Asn Glu His Val Ile Lys Tyr Ser Asn Glu Gly Ser Ser Lys Glu 
        915                 920                 925             


Met Gln Ile Lys Tyr Gly Lys Val Ala Val Glu Ser Glu Lys Ile Ile 
    930                 935                 940                 


Arg His Val Leu Leu Lys Asp Arg Ile Leu Arg Val Ile Cys Glu Asp 
945                 950                 955                 960 


Leu Leu Lys Ser Asp Lys Asn Thr Ser Ser Thr Lys Ser Phe Leu Leu 
                965                 970                 975     


Lys Asp Ile Ser Pro Trp Ser Glu Thr Asn Ile Leu Asn Lys Pro Asn 
            980                 985                 990         


Glu Phe Ser Tyr Asn Leu Arg Lys  Asn Ile Asp Gly Ser  Gly Thr Glu 
        995                 1000                 1005             


Tyr Cys  Thr Ile Val Ala Lys  Asp Ser Thr Glu Gln  Ile Arg Gln 
    1010                 1015                 1020             


Ile Asn  Glu Trp Asn Asp Leu  Ser Lys Glu Ile Lys  Ser Lys Phe 
    1025                 1030                 1035             


Leu Lys  Leu Asn Ala Glu Gln  Lys Ile Asp Phe Leu  Thr Thr Gln 
    1040                 1045                 1050             


Asp Glu  Lys Thr Lys Leu Val  Leu Leu Gly Gln Gln  Asn Tyr Gln 
    1055                 1060                 1065             


Trp Lys  Phe Ser Asp Phe Gly  Arg Phe Arg Arg Phe  Met Lys Asp 
    1070                 1075                 1080             


Lys Arg  Ile Asn Glu Met Val  Lys Tyr Phe Glu Pro  Lys Gln Ile 
    1085                 1090                 1095             


Pro Phe  Asp Leu Leu Glu Phe  Gln Ile Leu Gln Tyr  Asn Ile Tyr 
    1100                 1105                 1110             


Arg Glu  Lys Met Phe Asp Lys  Ile Phe Glu Leu Glu  Arg Val Met 
    1115                 1120                 1125             


Ser Glu  Arg Tyr Phe Glu Asp  Ile Lys Ser Lys His  Leu Glu Asn 
    1130                 1135                 1140             


Phe Lys  Tyr Asn Glu Val Gly  Phe Gln Thr Tyr Leu  Asn Val Leu 
    1145                 1150                 1155             


Ser Glu  Lys Ile Ala Ser Gly  Tyr Asp Ile Ala Ile  Leu Lys Trp 
    1160                 1165                 1170             


Gly Arg  Asn Lys Phe Ser His  Thr Glu Ile Val Tyr  Tyr Asn Phe 
    1175                 1180                 1185             


Ile Ser  Lys Ile Ala Val Gln  Asp Ile Glu Glu Phe  Glu Leu Lys 
    1190                 1195                 1200             


Lys His  Leu Glu Gly Tyr Lys  Glu Asn Val Ser Phe  Asn Ile Ala 
    1205                 1210                 1215             


Arg Asn  Ile Tyr Arg Val Phe  Ser Arg Glu Val Asp  Lys Thr Ile 
    1220                 1225                 1230             


Asn Leu  Ile Asn Asn Ser Phe  Lys Ile 
    1235                 1240         


<210>  2504
<211>  1029
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2504

Met His Val Thr Thr Thr Asn Lys Pro Leu Leu Ala Ala Tyr Leu Asn 
1               5                   10                  15      


Met Ala Arg Asn Asn Cys Tyr Met Ala Leu Ser His Ile Ala Glu Leu 
            20                  25                  30          


Met Gly Lys Ser Ser Val Met Asn Glu Asp Ala Ile Gln Glu Cys Ala 
        35                  40                  45              


Val Ile Arg Ala Leu Ala Gly Asn Ile Lys Pro Asp Glu Ser Phe Arg 
    50                  55                  60                  


Ile Ile Asp Met Val Asp Gln His Phe Pro Phe Ile Arg Leu Leu Leu 
65                  70                  75                  80  


Lys Ser Arg Asn Asn Ser Ser Pro Thr Asp Tyr Ala Asn Cys Leu Thr 
                85                  90                  95      


Asp Phe Ile Lys Gln Leu Asn Glu Leu Arg Asn Phe His Thr His Gln 
            100                 105                 110         


Leu His Lys Pro Tyr Ile Thr Asp Ala Lys Val Val Ala Gln Leu Gln 
        115                 120                 125             


Phe Leu Phe Asp Ala Ser Arg Arg Glu Val Lys Lys Arg Phe Ser Leu 
    130                 135                 140                 


Glu Glu Gln Asp Val Lys His Leu Val Arg Lys Ser Ile Val Ile Ile 
145                 150                 155                 160 


Asp Asn Asn Lys Val Ala Val Glu Lys Glu Asn Tyr Val Tyr Ala Phe 
                165                 170                 175     


Ala Asn Lys Glu Gly Gln Phe Thr Asn Lys Gly Ile Ala Phe Leu Ile 
            180                 185                 190         


Ser Leu Phe Ile Glu Lys Lys Tyr Ala Tyr Leu Phe Leu Lys Gln Leu 
        195                 200                 205             


Ser Gly Phe Lys Asn Ser Asn Thr Lys Gln His Lys Ala Thr Leu Glu 
    210                 215                 220                 


Val Phe Cys Phe Tyr His Ile Arg Ile Pro Gln Pro Lys Leu Gln Ser 
225                 230                 235                 240 


Asn Asn Thr Lys Ile Gly Phe Leu Leu Asp Ala Leu Glu Glu Leu Lys 
                245                 250                 255     


Arg Cys Pro Ala Glu Leu Tyr Glu His Ile Ala Lys Asn Asp Lys Gln 
            260                 265                 270         


Arg Phe Lys Ser Ala Gly Ile Thr Glu Asp Thr Asn Asp Gln Pro Glu 
        275                 280                 285             


Ala Ile Leu Lys Arg Asn Gly Asp Arg Phe Ser Tyr Leu Ala Leu Arg 
    290                 295                 300                 


Tyr Leu Glu Leu Thr Asn Ser Leu Pro Gly Leu Gln Phe Tyr Phe Asp 
305                 310                 315                 320 


Leu Gly Lys Tyr Tyr Phe Lys Val Tyr Glu Lys Ser Ile Asp Ser Glu 
                325                 330                 335     


Leu Arg Leu Arg Arg Leu His Lys Asn Met Arg Asp Phe Gly Arg Thr 
            340                 345                 350         


Asn Asp Phe Asp Thr Val Lys Met Pro Gln Leu Trp Gln Gln Leu Ile 
        355                 360                 365             


Lys Arg Thr Asp Glu Leu Ser Glu Asn Tyr Ala Glu Pro Tyr Ile Val 
    370                 375                 380                 


Tyr Thr Ile Pro His Tyr His Ile Val Asn Asn Gln Ile Gly Ile Trp 
385                 390                 395                 400 


Leu Asn Lys Glu Arg Gln Met Pro Ser Leu Thr Pro Lys Ile Ser Asn 
                405                 410                 415     


Ala Glu Pro Gln Ile Trp Leu Ser Leu Tyr Glu Leu Pro Ala Leu Leu 
            420                 425                 430         


Phe Tyr His Leu Leu Thr Lys Gly Asn Lys Gly Gln Lys Asn Val Leu 
        435                 440                 445             


Gln Ile Leu Ser Lys His Arg Thr Ala Ile His Ser Phe Phe Lys Asp 
    450                 455                 460                 


Ile Glu Ser Ser Lys Leu Leu Pro Gly Phe Thr Ile Glu Thr Leu Asn 
465                 470                 475                 480 


Val Glu Leu Glu Lys Arg Asn Leu Lys His Asp Lys Ile Pro Lys Pro 
                485                 490                 495     


Leu Leu Gln Tyr Leu Leu Gln Gln Lys Pro Leu Lys Ser Ile Val Glu 
            500                 505                 510         


Ile Ala Gly Glu Arg Leu Ser Glu Leu Gln Asn Glu Thr Ile Phe Leu 
        515                 520                 525             


Leu Asp Lys Ile Asp Ile Asp Ile Glu Lys Ala Lys Glu Lys Ile Gly 
    530                 535                 540                 


Gly Lys His Tyr Arg Pro Ile Gln Thr Gly Lys Ile Ala Asp Phe Leu 
545                 550                 555                 560 


Ala Arg Asp Met Leu Phe Phe Gln Pro Ala Ile Asp Lys Ile Lys Gly 
                565                 570                 575     


Lys Ala Thr Ser Thr Leu Phe Gln Val Leu Gln Ala Arg Leu Ala Phe 
            580                 585                 590         


Tyr Gly Arg Asp Lys Glu Leu Leu Glu Gly Leu Tyr Lys Glu Cys Asn 
        595                 600                 605             


Leu Ile Gln Ser Lys Asn Pro His Pro Phe Leu Ser Gly Leu Pro Ile 
    610                 615                 620                 


Thr Asn Asn Leu Met Asp Tyr Tyr Arg Asn Tyr Leu Ile Lys Arg Asn 
625                 630                 635                 640 


Gln Tyr Leu Asp Lys Cys Leu Lys Lys Cys Lys Gln Gly Lys Ile Gly 
                645                 650                 655     


Ser Gln Asp Phe His Phe Leu His Leu Gly Glu Arg Glu Arg Lys Asn 
            660                 665                 670         


Gly Asn Thr Tyr Tyr Thr Asn Leu Ala Gly Lys Phe Ile Lys Met Pro 
        675                 680                 685             


Leu Asn Phe Pro Arg Gly Leu Phe Met Glu Glu Leu Ile Asn Tyr Phe 
    690                 695                 700                 


Glu Ser Ser Gly Asp Leu His Met Gln Asn Ile Ile Lys Asn Thr Pro 
705                 710                 715                 720 


Arg Leu Ser Thr Thr Phe Leu Leu Lys Glu Tyr Ile Asn Asn Val Leu 
                725                 730                 735     


Ser Asp Asp Thr Pro Asp Phe Tyr Asn Trp Lys Arg Ser Tyr Thr Val 
            740                 745                 750         


Phe Asn Arg Tyr Tyr Asp Lys Arg Lys Gln Asn Ser Arg Asp Ala Ile 
        755                 760                 765             


Thr Lys Ile Tyr Phe Asp Thr Ser Gln Leu Ser Glu Glu Ala Asn Lys 
    770                 775                 780                 


Ile Lys Ala Ala Ile Lys Lys Ile Glu Lys Ser Asp Ile Lys Gly Ala 
785                 790                 795                 800 


Glu Ser Ile Lys Arg Asn Tyr Lys Phe Tyr Gly Asp Asn Glu Lys Gln 
                805                 810                 815     


Leu Arg Gln Ala Lys Ala Cys Asp Thr Ile Leu Phe Leu Ala Ile Arg 
            820                 825                 830         


Asp Leu Phe Pro Thr Ile Glu Ser Ser Val Phe Lys Gly Leu Ala Ile 
        835                 840                 845             


Glu Gln Phe Arg Leu Ser Asp Ile Leu Pro Asp Ala Glu Lys Gly Ile 
    850                 855                 860                 


Leu Ser Gln Ser Ile Glu Ile Arg Leu Pro Leu Tyr Asn Lys Phe Ile 
865                 870                 875                 880 


Ile Gln Lys Gly Leu Lys Leu Lys Asn Tyr Gly Asp Phe Arg Arg Phe 
                885                 890                 895     


Leu Lys Asp Arg Arg Leu Glu Ser Leu Met Pro Tyr Phe Glu Glu Asp 
            900                 905                 910         


Asp Ile Asp Arg Ser Ser Leu Glu Lys Glu Leu Glu Asp Tyr Asp Thr 
        915                 920                 925             


Ala Arg Ile Glu Ile His Arg Val Val Leu Asp Phe Glu Ser His Val 
    930                 935                 940                 


Ile Thr Met Tyr Gln Leu Asn Tyr Leu Asn Pro Glu Asp Pro Cys Ile 
945                 950                 955                 960 


Asn His Glu Thr Ile Leu Asn Cys Phe Phe Gln Asn Asp Pro Ser Asp 
                965                 970                 975     


Ile Arg Lys Gln Leu Met Glu Asn Ile Arg Asn Arg Phe Ser His Asn 
            980                 985                 990         


Glu Tyr Pro Asp Phe Glu Lys Phe  Lys Glu Ile Ile Gln  Glu Asn His 
        995                 1000                 1005             


Gln Gln  Lys Thr Ile Ala Gly  Lys Phe Val Thr Leu  Ala Asn Gln 
    1010                 1015                 1020             


Tyr Phe  Ser Val Glu Glu 
    1025                 


<210>  2505
<211>  1029
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2505

Met His Val Thr Thr Thr Asn Lys Pro Leu Leu Ala Ala Tyr Leu Asn 
1               5                   10                  15      


Met Ala Arg Asn Asn Cys Tyr Met Ala Leu Ser His Ile Ala Glu Leu 
            20                  25                  30          


Met Gly Lys Ser Ser Val Met Asn Glu Asp Ala Ile Gln Glu Cys Ala 
        35                  40                  45              


Val Ile Arg Ala Leu Ala Gly Asn Ile Lys Pro Asp Glu Ser Phe Arg 
    50                  55                  60                  


Ile Ile Asp Met Val Asp Gln His Phe Pro Phe Ile Arg Leu Leu Leu 
65                  70                  75                  80  


Lys Ser Arg Asn Asn Ser Ser Pro Thr Asp Tyr Ala Asn Cys Leu Thr 
                85                  90                  95      


Asp Phe Ile Lys Gln Leu Asn Glu Leu Arg Asn Phe His Thr His Gln 
            100                 105                 110         


Leu His Lys Pro Tyr Ile Thr Asp Ala Lys Val Val Ala Gln Leu Gln 
        115                 120                 125             


Phe Leu Phe Asp Ala Ser Arg Arg Glu Val Lys Lys Arg Phe Ser Leu 
    130                 135                 140                 


Glu Glu Gln Asp Val Lys His Leu Val Arg Lys Ser Ile Val Ile Ile 
145                 150                 155                 160 


Asp Asn Asn Lys Val Ala Val Glu Lys Glu Asn Tyr Val Tyr Ala Phe 
                165                 170                 175     


Ala Asn Lys Glu Gly Gln Phe Thr Asn Lys Gly Ile Ala Phe Leu Ile 
            180                 185                 190         


Ser Leu Phe Ile Glu Lys Lys Tyr Ala Tyr Leu Phe Leu Lys Gln Leu 
        195                 200                 205             


Ser Gly Phe Lys Asn Ser Asn Thr Lys Gln His Lys Ala Thr Leu Glu 
    210                 215                 220                 


Val Phe Cys Phe Tyr His Ile Arg Ile Pro Gln Pro Lys Leu Gln Ser 
225                 230                 235                 240 


Asn Asn Thr Lys Ile Gly Phe Leu Leu Asp Ala Leu Glu Glu Leu Lys 
                245                 250                 255     


Arg Cys Pro Ala Glu Leu Tyr Glu His Ile Ala Lys Asn Asp Lys Gln 
            260                 265                 270         


Arg Phe Lys Ser Ala Gly Ile Thr Glu Asp Thr Asn Asp Gln Pro Glu 
        275                 280                 285             


Ala Ile Leu Lys Arg Asn Gly Asp Arg Phe Ser Tyr Leu Ala Leu Arg 
    290                 295                 300                 


Tyr Leu Glu Leu Thr Asn Ser Leu Pro Gly Leu Gln Phe Tyr Phe Asp 
305                 310                 315                 320 


Leu Gly Lys Tyr Tyr Phe Lys Val Tyr Glu Lys Ser Ile Asp Ser Glu 
                325                 330                 335     


Leu Arg Leu Arg Arg Leu His Lys Asn Met Arg Asp Phe Gly Arg Thr 
            340                 345                 350         


Asn Asp Phe Asp Thr Val Lys Met Pro Gln Leu Trp Gln Gln Leu Ile 
        355                 360                 365             


Lys Arg Thr Asp Glu Leu Ser Glu Asn Tyr Ala Glu Pro Tyr Ile Val 
    370                 375                 380                 


Tyr Thr Ile Pro His Tyr His Ile Val Asn Asn Gln Ile Gly Ile Trp 
385                 390                 395                 400 


Leu Asn Lys Glu Arg Gln Met Pro Ser Leu Thr Pro Lys Ile Ser Asn 
                405                 410                 415     


Ala Glu Pro Gln Ile Trp Leu Ser Leu Tyr Glu Leu Pro Ala Leu Leu 
            420                 425                 430         


Phe Tyr His Leu Leu Thr Lys Gly Asn Lys Gly Gln Lys Asn Val Leu 
        435                 440                 445             


Gln Ile Leu Ser Lys His Arg Thr Ala Ile His Ser Phe Phe Lys Asp 
    450                 455                 460                 


Ile Glu Ser Ser Lys Leu Leu Pro Gly Phe Thr Ile Glu Thr Leu Asn 
465                 470                 475                 480 


Val Glu Leu Glu Lys Arg Asn Leu Lys His Asp Lys Ile Pro Lys Pro 
                485                 490                 495     


Leu Leu Gln Tyr Leu Leu Gln Gln Lys Pro Leu Lys Ser Ile Val Glu 
            500                 505                 510         


Ile Ala Gly Glu Arg Leu Ser Glu Leu Gln Asn Glu Thr Ile Phe Leu 
        515                 520                 525             


Leu Asp Lys Ile Asp Ile Asp Ile Glu Lys Ala Lys Glu Lys Ile Gly 
    530                 535                 540                 


Gly Lys His Tyr Arg Pro Ile Gln Thr Gly Lys Ile Ala Asp Phe Leu 
545                 550                 555                 560 


Ala Arg Asp Met Leu Phe Phe Gln Pro Ala Ile Asp Lys Ile Lys Gly 
                565                 570                 575     


Lys Ala Thr Ser Thr Leu Phe Gln Val Leu Gln Ala Arg Leu Ala Phe 
            580                 585                 590         


Tyr Gly Arg Asp Lys Glu Leu Leu Glu Gly Leu Tyr Lys Glu Cys Asn 
        595                 600                 605             


Leu Ile Gln Ser Lys Asn Pro His Pro Phe Leu Ser Gly Leu Pro Ile 
    610                 615                 620                 


Thr Asn Asn Leu Met Asp Tyr Tyr Arg Asn Tyr Leu Ile Lys Arg Asn 
625                 630                 635                 640 


Gln Tyr Leu Asp Lys Cys Leu Lys Lys Cys Lys Gln Gly Lys Ile Gly 
                645                 650                 655     


Ser Gln Asp Phe His Phe Leu His Leu Gly Glu Arg Glu Arg Lys Asn 
            660                 665                 670         


Gly Asn Thr Tyr Tyr Thr Asn Leu Ala Gly Lys Phe Ile Lys Met Pro 
        675                 680                 685             


Leu Asn Phe Pro Arg Gly Leu Phe Met Glu Glu Leu Ile Asn Tyr Phe 
    690                 695                 700                 


Glu Ser Ser Gly Asp Leu His Met Gln Asn Ile Ile Lys Asn Thr Pro 
705                 710                 715                 720 


Arg Leu Ser Thr Thr Phe Leu Leu Lys Glu Tyr Ile Asn Asn Val Leu 
                725                 730                 735     


Ser Asp Asp Thr Pro Asp Phe Tyr Asn Trp Lys Arg Ser Tyr Thr Val 
            740                 745                 750         


Phe Asn Arg Tyr Tyr Asp Lys Arg Lys Gln Asn Ser Arg Asp Ala Ile 
        755                 760                 765             


Thr Lys Ile Tyr Phe Asp Thr Ser Gln Leu Ser Glu Glu Ala Asn Lys 
    770                 775                 780                 


Ile Lys Ala Ala Ile Lys Lys Ile Glu Lys Ser Asp Ile Lys Gly Ala 
785                 790                 795                 800 


Glu Ser Ile Lys Arg Asn Tyr Lys Phe Tyr Gly Asp Asn Glu Lys Gln 
                805                 810                 815     


Leu Arg Gln Ala Lys Ala Cys Asp Thr Ile Leu Phe Leu Ala Ile Arg 
            820                 825                 830         


Asp Leu Phe Pro Thr Ile Glu Ser Ser Val Phe Lys Gly Leu Ala Ile 
        835                 840                 845             


Glu Gln Phe Arg Leu Ser Asp Ile Leu Pro Asp Ala Glu Lys Gly Ile 
    850                 855                 860                 


Leu Ser Gln Ser Ile Glu Ile Arg Leu Pro Leu Tyr Asn Lys Phe Ile 
865                 870                 875                 880 


Ile Gln Lys Gly Leu Lys Leu Lys Asn Tyr Gly Asp Phe Arg Arg Phe 
                885                 890                 895     


Leu Lys Asp Arg Arg Leu Glu Ser Leu Met Pro Tyr Phe Glu Glu Asp 
            900                 905                 910         


Asp Ile Asp Arg Ser Ser Leu Glu Lys Glu Leu Glu Asp Tyr Asp Thr 
        915                 920                 925             


Ala Arg Ile Glu Ile His Arg Val Val Leu Asp Phe Glu Ser His Val 
    930                 935                 940                 


Ile Thr Met Tyr Gln Leu Asn Tyr Leu Asn Pro Glu Asp Pro Cys Ile 
945                 950                 955                 960 


Asn His Glu Thr Ile Leu Asn Cys Phe Phe Gln Asn Asp Pro Ser Asp 
                965                 970                 975     


Ile Arg Lys Gln Leu Met Glu Asn Ile Arg Asn Arg Phe Ser His Asn 
            980                 985                 990         


Glu Tyr Pro Asp Phe Glu Lys Phe  Lys Glu Ile Ile Gln  Glu Asn His 
        995                 1000                 1005             


Gln Gln  Lys Thr Ile Ala Gly  Lys Phe Val Thr Leu  Ala Asn Gln 
    1010                 1015                 1020             


Tyr Phe  Ser Val Glu Glu 
    1025                 


<210>  2506
<211>  1129
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2506

Met Lys Glu Glu Glu Glu Lys Gly Lys Thr Pro Val Val Ser Thr Tyr 
1               5                   10                  15      


Asn Lys Asp Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg 
            20                  25                  30          


His Asn Val Tyr Ile Thr Ile Asn His Ile Asn Lys Leu Leu Glu Ile 
        35                  40                  45              


Arg Glu Ile Asp Asn Asp Glu Lys Val Leu Asp Ile Lys Ala Leu Trp 
    50                  55                  60                  


Gln Lys Val Asn Lys Asp Leu Asn Gln Lys Ala Arg Leu Arg Glu Leu 
65                  70                  75                  80  


Met Thr Lys His Phe Pro Phe Leu Glu Thr Ala Ile Tyr Thr Lys Asn 
                85                  90                  95      


Lys Glu Asp Lys Lys Glu Val Lys Glu Glu Lys Gln Ala Lys Ala Gln 
            100                 105                 110         


Ser Phe Asp Ser Leu Asn His Cys Leu Phe Leu Phe Leu Glu Lys Leu 
        115                 120                 125             


Gln Glu Ala Arg Asn Tyr Tyr Ser His Tyr Lys Tyr Ser Glu Ser Ser 
    130                 135                 140                 


Lys Glu Pro Met Leu Glu Lys Glu Leu Leu Lys Lys Met Tyr Asn Ile 
145                 150                 155                 160 


Phe Asp Asn Asn Ile Gln Leu Val Ile Lys Asp Tyr Gln His Asn Lys 
                165                 170                 175     


Asp Ile Asn Pro Asp Glu Asp Phe Lys His Leu Asp Arg Thr Glu Glu 
            180                 185                 190         


Asp Phe Asn Tyr Tyr Phe Ala Arg Asn Lys Lys Gly Asn Ile Thr Ala 
        195                 200                 205             


Ser Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala 
    210                 215                 220                 


Ile Trp Met Gln Gln Lys Leu Thr Gly Phe Lys Asp Asn Arg Glu Asn 
225                 230                 235                 240 


Lys Lys Lys Met Thr His Glu Val Phe Cys Arg Ser Arg Met Leu Leu 
                245                 250                 255     


Pro Lys Leu Arg Leu Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu 
            260                 265                 270         


Asp Met Leu Asn Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg 
        275                 280                 285             


Leu Lys Gly Glu Asp Arg Lys Lys Phe Glu Val Pro Phe Asp Ser Thr 
    290                 295                 300                 


Asp Glu Asp Tyr Asp Ala Glu Gln Asp Pro Phe Lys Asn Thr Leu Ile 
305                 310                 315                 320 


Arg His Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe Asp Tyr 
                325                 330                 335     


Asn Glu Ile Phe Lys Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr 
            340                 345                 350         


His Phe Ser Ile Tyr Lys Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg 
        355                 360                 365             


His Leu Thr His Lys Leu Tyr Gly Phe Glu Arg Ile Gln Glu Phe Thr 
    370                 375                 380                 


Lys Gln His Arg Pro Asp Asp Trp Lys Ala Ile Val Lys Asp Phe Asp 
385                 390                 395                 400 


Thr Tyr Glu Thr Ser Glu Glu Pro Tyr Ile Ser Glu Thr Thr Pro His 
                405                 410                 415     


Tyr His Leu Glu Asn Gln Lys Ile Gly Ile Arg Phe Arg Asn Gly Asn 
            420                 425                 430         


Asn Asp Ile Trp Pro Ser Leu Glu Thr Asn Gly Glu Asn Asn Glu Lys 
        435                 440                 445             


Ser Lys Tyr Lys Leu Asp Lys Pro Tyr Gln Ala Glu Ala Phe Leu Ser 
    450                 455                 460                 


Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Lys Lys 
465                 470                 475                 480 


Glu Glu Pro Asn Asn Asp Lys Lys Asn Ala Ser Arg Val Glu Gly Phe 
                485                 490                 495     


Ile Lys Arg Glu Ile Arg Asp Ile Phe Lys Leu Tyr Asp Ala Phe Ala 
            500                 505                 510         


Asn Asp Glu Ile Asn Asn Ile Asp Asp Leu Lys Lys Tyr Cys Lys Asp 
        515                 520                 525             


Lys His Ile Glu Ile Arg His Leu Pro Lys Gln Met Ile Ala Ile Leu 
    530                 535                 540                 


Glu Ser Lys Pro Lys Asp Met Ala Lys Glu Ala Lys Arg Lys Gln Lys 
545                 550                 555                 560 


Glu Met Val Lys Asp Thr Lys Lys Leu Leu Ala Thr Leu Glu Lys Gln 
                565                 570                 575     


Thr Gln Lys Glu Lys Glu Asp Asp Gly Arg Asn Val Lys Leu Leu Lys 
            580                 585                 590         


Ser Gly Glu Ile Ala Arg Trp Leu Val Asn Asp Met Met Arg Phe Gln 
        595                 600                 605             


Pro Val Gln Lys Asp Asn Glu Gly Lys Pro Leu Asn Asn Ser Lys Ala 
    610                 615                 620                 


Asn Ser Thr Glu Tyr Gln Met Leu Gln Arg Ser Leu Ala Leu Tyr Asn 
625                 630                 635                 640 


Lys Glu Glu Asn Pro Thr Arg Tyr Phe Arg Gln Val Asn Leu Ile Glu 
                645                 650                 655     


Ser Ser Asn Pro His Pro Phe Leu Lys Trp Thr Lys Trp Glu Glu Cys 
            660                 665                 670         


Asn Asn Ile Leu Thr Phe Tyr Tyr Thr Tyr Leu Thr Lys Lys Ile Glu 
        675                 680                 685             


Phe Leu Asn Lys Leu Lys Pro Glu Asp Trp Lys Lys Asn Gln Tyr Phe 
    690                 695                 700                 


Leu Lys Leu Lys Glu Pro Lys Thr Asn Arg Lys Thr Leu Val Gln Gly 
705                 710                 715                 720 


Trp Lys Asn Gly Phe Asn Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile 
                725                 730                 735     


Arg Glu Trp Phe Glu Arg His Gln Asn Asp Ser Glu Glu Tyr Lys Lys 
            740                 745                 750         


Val Glu Lys Leu Asn Lys Ala Gly Leu Val Thr Lys Val Ile Pro Leu 
        755                 760                 765             


Phe Phe Lys Lys Glu Asp Ser Lys Asp Lys Glu Glu Tyr Leu Lys Lys 
    770                 775                 780                 


Asp Thr Gln Lys Glu Ile Asn Asp Cys Val Gln Pro Phe Tyr Asn Phe 
785                 790                 795                 800 


Pro Tyr Asn Val Gly Asn Ile His Lys Ser Asp Glu Lys Asp Phe Leu 
                805                 810                 815     


His Arg Glu Glu Arg Ile Glu Leu Trp Asp Lys Lys Lys Asp Lys Phe 
            820                 825                 830         


Lys Gly Tyr Lys Glu Lys Ile Lys Ser Lys Lys Leu Thr Glu Lys Glu 
        835                 840                 845             


Lys Glu Glu Phe Arg Ser Tyr Leu Glu Phe Gln Ser Trp Asn Asn Phe 
    850                 855                 860                 


Glu Arg Glu Leu Arg Leu Val Arg Asn Gln Asp Ile Val Thr Trp Leu 
865                 870                 875                 880 


Leu Cys Lys Glu Leu Ile Asp Lys Leu Lys Ile Asp Glu Leu Asn Ile 
                885                 890                 895     


Glu Glu Leu Lys Lys Leu Arg Leu Asn Asn Ile Asp Thr Asp Thr Ala 
            900                 905                 910         


Lys Lys Glu Lys Asn Asn Ile Leu Asn Arg Val Met Pro Met Glu Leu 
        915                 920                 925             


Pro Val Met Val Tyr Glu Val Asn Lys Ala Gly Asn Ile Ile Lys Asn 
    930                 935                 940                 


Lys Pro Leu His Thr Ile Tyr Ile Lys Glu Ala Lys Thr Lys Leu Leu 
945                 950                 955                 960 


Lys Gln Gly Asn Phe Lys Ala Leu Val Lys Asp Arg Arg Leu Asn Gly 
                965                 970                 975     


Leu Phe Ser Phe Val Lys Thr Asn Ser Glu Ala Glu Ser Lys Arg Asn 
            980                 985                 990         


Pro Ile Ser Lys Leu Leu Val Glu  His Glu Leu Gly Glu  Tyr Gln Glu 
        995                 1000                 1005             


Ala Arg  Ile Glu Ile Ile Lys  Asp Met Leu Ala Leu  Glu Glu Thr 
    1010                 1015                 1020             


Leu Ile  Asn Lys Tyr Lys Asp  Leu Pro Thr Asn Lys  Phe Ser Asp 
    1025                 1030                 1035             


Met Leu  Asn Ser Trp Leu Glu  Gly Lys Asp Glu Ala  Asp Lys Ala 
    1040                 1045                 1050             


Arg Phe  Gln Asn Asp Val Asp  Phe Leu Ile Ala Val  Arg Asn Ala 
    1055                 1060                 1065             


Phe Ser  His Asn Gln Tyr Pro  Met His Asn Lys Ile  Glu Phe Ala 
    1070                 1075                 1080             


Asn Ile  Lys Pro Phe Ser Leu  Tyr Thr Met Asn Asn  Ser Glu Glu 
    1085                 1090                 1095             


Lys Gly  Leu Gly Ile Ala Asn  Gln Leu Lys Asp Lys  Thr Lys Glu 
    1100                 1105                 1110             


Thr Lys  Asp Lys Ile Ile Glu  Ile Glu Lys Pro Ile  Glu Thr Lys 
    1115                 1120                 1125             


Glu 
    


<210>  2507
<211>  1141
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2507

Met Glu Asp Asp Lys Lys Thr Thr Glu Ser Thr Asn Met Leu Asp Asn 
1               5                   10                  15      


Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val Tyr 
            20                  25                  30          


Ile Thr Val Asn His Ile Asn Lys Val Leu Glu Leu Lys Asn Lys Lys 
        35                  40                  45              


Asp Gln Asp Ile Ile Ile Asp Asn Asp Gln Asp Ile Leu Ala Ile Lys 
    50                  55                  60                  


Thr His Trp Glu Lys Val Asn Gly Asp Leu Asn Lys Thr Glu Arg Leu 
65                  70                  75                  80  


Arg Glu Leu Met Thr Lys His Phe Pro Phe Leu Glu Thr Ala Ile Tyr 
                85                  90                  95      


Thr Lys Asn Lys Glu Asp Lys Glu Glu Val Lys Gln Glu Lys Gln Ala 
            100                 105                 110         


Lys Ala Gln Ser Phe Asp Ser Leu Lys His Cys Leu Phe Leu Phe Leu 
        115                 120                 125             


Glu Lys Leu Gln Glu Ala Arg Asn Tyr Tyr Ser His Tyr Lys Tyr Ser 
    130                 135                 140                 


Glu Ser Thr Lys Glu Pro Met Leu Glu Lys Glu Leu Leu Lys Lys Met 
145                 150                 155                 160 


Tyr Asn Ile Phe Asp Asp Asn Ile Gln Leu Val Ile Lys Asp Tyr Gln 
                165                 170                 175     


His Asn Lys Asp Ile Asn Pro Asp Glu Asp Phe Lys His Leu Asp Arg 
            180                 185                 190         


Thr Glu Glu Glu Phe Asn Tyr Tyr Phe Thr Arg Asn Lys Lys Gly Asn 
        195                 200                 205             


Ile Thr Ala Ser Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys 
    210                 215                 220                 


Lys Asp Ala Ile Trp Met Gln Gln Lys Leu Arg Gly Phe Lys Asp Asn 
225                 230                 235                 240 


Arg Glu Ser Lys Lys Lys Met Thr His Glu Val Phe Cys Arg Arg Arg 
                245                 250                 255     


Met Leu Leu Pro Lys Leu Arg Leu Glu Ser Thr Gln Thr Gln Asp Trp 
            260                 265                 270         


Ile Leu Leu Asp Met Leu Asn Glu Leu Ile Arg Cys Pro Lys Ser Leu 
        275                 280                 285             


Tyr Glu Arg Leu Gln Gly Glu Asp Arg Glu Lys Phe Lys Val Pro Phe 
    290                 295                 300                 


Asp Pro Ala Asp Glu Asp Tyr Asp Ala Glu Gln Glu Pro Phe Lys Asn 
305                 310                 315                 320 


Thr Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr 
                325                 330                 335     


Phe Asp Tyr Asn Glu Ile Phe Thr Asn Leu Arg Phe Gln Ile Asp Leu 
            340                 345                 350         


Gly Thr Tyr His Phe Ser Ile Tyr Lys Lys Leu Ile Gly Gly Gln Lys 
        355                 360                 365             


Glu Asp Arg His Leu Thr His Lys Leu Tyr Gly Phe Glu Arg Ile Gln 
    370                 375                 380                 


Glu Phe Ala Lys Gln Asn Arg Thr Asp Glu Trp Lys Ala Ile Val Lys 
385                 390                 395                 400 


Asp Leu Asp Thr Tyr Glu Thr Ser Asn Glu Arg Tyr Ile Ser Glu Thr 
                405                 410                 415     


Ile Pro His Tyr His Leu Glu Asn Gln Lys Ile Gly Ile Arg Phe Arg 
            420                 425                 430         


Asn Asp Asn Asp Glu Ile Trp Pro Ser Leu Lys Thr Asn Gly Glu Asn 
        435                 440                 445             


Asn Glu Lys Arg Lys Tyr Lys Leu Asp Lys Gln Tyr Gln Ala Glu Ala 
    450                 455                 460                 


Phe Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu 
465                 470                 475                 480 


Leu Lys Met Glu Asn Thr Asp Asn Gly Lys Glu Asn Asn Glu Val Gly 
                485                 490                 495     


Thr Lys Lys Lys Arg Asn Lys Asn Asn Glu Gln Glu Lys His Lys Ile 
            500                 505                 510         


Glu Glu Ile Ile Glu Asn Lys Ile Lys Asp Ile Tyr Ala Leu Tyr Asp 
        515                 520                 525             


Ala Phe Ala Asn Gly Glu Ile Asn Ser Glu Glu Glu Leu Lys Glu Tyr 
    530                 535                 540                 


Leu Lys Gly Lys Asp Ile Glu Ile Val His Leu Pro Lys Gln Met Ile 
545                 550                 555                 560 


Ala Ile Leu Glu Ser Lys Pro Lys Asp Met Val Lys Glu Ala Lys Arg 
                565                 570                 575     


Lys Gln Lys Glu Met Val Lys Asp Thr Lys Lys Leu Leu Ala Ala Leu 
            580                 585                 590         


Glu Lys Gln Thr Gln Gly Glu Ile Glu Asp Gly Gly Arg Asn Ile Arg 
        595                 600                 605             


Leu Leu Lys Ser Gly Glu Ile Ala Arg Trp Leu Val Asn Asp Met Met 
    610                 615                 620                 


Arg Phe Gln Pro Val Gln Lys Asp Asn Glu Gly Asn Pro Leu Asn Asn 
625                 630                 635                 640 


Ser Lys Ala Asn Ser Thr Glu Tyr Gln Met Leu Gln Arg Ser Leu Ala 
                645                 650                 655     


Leu Tyr Asn Lys Glu Glu Lys Pro Thr Arg Tyr Phe Arg Gln Val Asn 
            660                 665                 670         


Leu Ile Asn Ser Ser Asn Pro His Pro Phe Leu Lys Trp Thr Lys Trp 
        675                 680                 685             


Glu Glu Cys Asn Asn Ile Leu Ser Phe Tyr Arg Ser Tyr Leu Thr Lys 
    690                 695                 700                 


Lys Ile Glu Phe Leu Asn Lys Leu Lys Pro Glu Glu Trp Lys Lys Asn 
705                 710                 715                 720 


Gln Tyr Phe Leu Lys Leu Lys Glu Pro Lys Thr Asn Arg Glu Thr Leu 
                725                 730                 735     


Val Gln Gly Trp Lys Asn Gly Phe Asn Leu Pro Arg Gly Ile Phe Thr 
            740                 745                 750         


Glu Pro Ile Arg Glu Trp Phe Lys Arg His Gln Asn Asp Ser Lys Glu 
        755                 760                 765             


Tyr Glu Lys Val Glu Ala Leu Asp Arg Val Gly Leu Val Ala Lys Val 
    770                 775                 780                 


Ile Pro Leu Phe Phe Lys Glu Glu Tyr Phe Lys Glu Asp Ala Gln Lys 
785                 790                 795                 800 


Glu Ile Asn Asn Cys Val Gln Pro Phe Tyr Ser Phe Pro Tyr Asn Val 
                805                 810                 815     


Gly Asn Ile His Lys Pro Asp Glu Lys Asp Phe Leu Pro Ser Glu Glu 
            820                 825                 830         


Arg Lys Lys Arg Trp Gly Asp Lys Lys Tyr Lys Phe Lys Gly Tyr Lys 
        835                 840                 845             


Ala Lys Val Lys Ser Lys Lys Leu Thr Asp Lys Glu Lys Glu Glu Tyr 
    850                 855                 860                 


Arg Ser Tyr Leu Glu Phe Gln Ser Trp Asn Lys Phe Glu Arg Glu Leu 
865                 870                 875                 880 


Arg Leu Val Arg Asn Gln Asp Ile Val Thr Trp Leu Leu Cys Thr Glu 
                885                 890                 895     


Leu Ile Asp Lys Leu Lys Val Glu Gly Leu Asn Val Glu Glu Leu Gln 
            900                 905                 910         


Lys Leu Arg Leu Lys Asp Ile Asp Thr Asp Thr Ala Lys Gln Glu Lys 
        915                 920                 925             


Asn Asn Ile Leu Asn Arg Ile Met Pro Met Gln Leu Pro Val Thr Val 
    930                 935                 940                 


Tyr Glu Ile Asp Asp Ser His Asn Ile Val Lys Asp Lys Pro Leu His 
945                 950                 955                 960 


Thr Val Tyr Ile Glu Glu Thr Lys Thr Lys Leu Leu Lys Gln Gly Asn 
                965                 970                 975     


Phe Lys Ala Leu Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe 
            980                 985                 990         


Val Asp Thr Ser Ser Lys Ala Glu  Leu Lys Asp Lys Pro  Ile Ser Lys 
        995                 1000                 1005             


Ser Val  Val Glu Tyr Glu Leu  Gly Glu Tyr Gln Asn  Ala Arg Ile 
    1010                 1015                 1020             


Glu Thr  Ile Lys Asp Met Leu  Leu Leu Glu Glu Thr  Leu Ile Lys 
    1025                 1030                 1035             


Lys Tyr  Lys Thr Leu Pro Thr  Asn Lys Phe Ser Ala  Met Leu Asn 
    1040                 1045                 1050             


Gly Trp  Leu Glu Gly Lys Asp  Glu Ala Asp Lys Ala  Arg Phe Gln 
    1055                 1060                 1065             


Asn Asp  Val Lys Leu Leu Val  Ala Val Arg Asn Ala  Phe Ser His 
    1070                 1075                 1080             


Asn Gln  Tyr Pro Met Arg Asn  Arg Ile Ala Phe Ala  Asn Ile Asn 
    1085                 1090                 1095             


Pro Phe  Ser Leu Ser Ser Ala  Asn Thr Ser Glu Glu  Lys Lys Leu 
    1100                 1105                 1110             


Asp Ile  Ala Asn Gln Leu Lys  Asp Lys Thr His Lys  Thr Ile Glu 
    1115                 1120                 1125             


Lys Ile  Ile Glu Ile Glu Lys  Pro Ile Glu Thr Lys  Glu 
    1130                 1135                 1140     


<210>  2508
<211>  1152
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2508

Met Thr Leu Pro Thr Asp Asn Thr Phe Ile Glu Arg Pro Asp Glu Lys 
1               5                   10                  15      


Ile Leu Tyr Gln Asn Lys Leu Phe Phe Gly Ala Tyr Leu Asn Met Ala 
            20                  25                  30          


Gln His Asn Ala Tyr Leu Ile Ile Lys Asp Ile Ser Glu Gln Phe Gly 
        35                  40                  45              


Leu Asp Ile Ser Thr Leu Gln Glu Asn Gln Leu Glu Ser Ala Asp Leu 
    50                  55                  60                  


Ile Lys Lys Leu Lys Gly Lys Gly Gly Arg Pro Lys Asn Ser Val Gln 
65                  70                  75                  80  


Met Thr Asn Ala Leu Val Arg Arg Leu Pro Phe Leu Glu Ala Met Lys 
                85                  90                  95      


Ala Pro Glu Glu Ser Thr Tyr Lys Ala Gly Thr Glu Lys Glu Lys Glu 
            100                 105                 110         


Val Ile His Ala Lys Glu Ile Gln Ser Gly Glu Val Gly Lys Ile Leu 
        115                 120                 125             


Thr Thr Ala Phe Glu Phe Met Gly Gln Leu Arg Asn Phe Tyr Ser His 
    130                 135                 140                 


Tyr His His Glu Asp Val Asp Phe Lys Asp Phe Ser Val Ile Glu Ile 
145                 150                 155                 160 


Ile Phe Asp Asn Ala Ile Lys Arg Ala Ile Lys Arg Ile Pro Asp Val 
                165                 170                 175     


Asn Glu Glu Asn Thr Asn His Leu Leu Asn Ala Pro Thr Tyr Ala Met 
            180                 185                 190         


Tyr Lys Asp Gly Lys Leu Thr Asn Leu Gly Leu Thr Phe Phe Ile Cys 
        195                 200                 205             


Leu Phe Leu Glu Arg Lys Tyr Ala Tyr Leu Phe Leu Met Gln Leu Glu 
    210                 215                 220                 


His Phe Lys Gly Gln Asn Asp Phe Val Tyr Ser Asn Arg Arg Cys Phe 
225                 230                 235                 240 


Thr Asp Leu Ser Cys Asn Leu Pro Lys Pro Lys Leu Gly Ser Ser Glu 
                245                 250                 255     


Ile Glu Met Asp Ile Leu Gly Glu Leu Ala Arg Cys Pro Lys Glu Leu 
            260                 265                 270         


Phe Tyr Arg Leu Ser Glu Glu Asp Lys Asn Lys Phe Phe Ala Glu Gln 
        275                 280                 285             


Lys Glu Thr Glu Asp Glu Ile Pro Pro Pro Ile Met Lys Arg Lys Asp 
    290                 295                 300                 


Asp Arg Phe Ala Ser Phe Ala Leu Arg Tyr Leu Glu Glu Lys Arg Leu 
305                 310                 315                 320 


Asn Lys Met Arg Phe Gln Ile His Leu Gly Lys Val Arg Arg Ile Gly 
                325                 330                 335     


Glu Lys His Gln Tyr Asp Lys Thr Ile Ala Gly Val Glu Ala Glu Arg 
            340                 345                 350         


Val Ile Met Glu Asn Leu Arg Thr Phe Ala Lys Leu Ser Glu Thr Asn 
        355                 360                 365             


Thr Glu Lys Thr Pro Glu His Trp Arg Val Phe Asn Arg Asp Thr Asn 
    370                 375                 380                 


Lys Lys Asp Leu Ile Arg Thr Glu Ile Glu Gln Phe Arg Pro Arg His 
385                 390                 395                 400 


Gln Ile Thr Gly Asn Arg Ile Ala Leu Lys Phe Leu Thr Glu Glu Arg 
                405                 410                 415     


Asn Ser Val Phe Pro Asp Leu Lys Phe Asp Asn Asn Gln Thr Lys Leu 
            420                 425                 430         


Gln Ala Leu Asp Thr Pro Asp Ala Ile Leu Ser Thr Tyr Glu Leu Gln 
        435                 440                 445             


Asn Leu Val Met Tyr Asp Gln Leu His Lys Glu Gly Ala Ile Glu Lys 
    450                 455                 460                 


Asp Val Glu Thr Phe Ile Ala Asp Tyr Ile Leu Asn Phe Arg Lys Phe 
465                 470                 475                 480 


Cys Glu Ala Val Asp Lys Gly Glu Val Thr Pro Val Ala Asp Ala Asp 
                485                 490                 495     


Phe Ile Lys Val Val Lys Ala Ser Gly Lys Ser Lys Pro Glu Tyr Ser 
            500                 505                 510         


Glu Ala Gln Leu Val Glu Leu Lys Asn Arg Gln Gln Ser Leu Lys Gly 
        515                 520                 525             


Ile Leu Thr Asn Tyr Gly Leu Gln Ile Gln Gln Leu Pro Asp Asn Leu 
    530                 535                 540                 


Arg Glu Tyr Leu Leu Gly Tyr Ala Pro Val Asn Tyr Lys Arg Glu Ala 
545                 550                 555                 560 


Leu Arg Ile Leu Glu Thr Lys Phe Ser Glu Thr Leu Lys Leu Arg Thr 
                565                 570                 575     


Asp Ser Gln Lys Gly Phe Gly Pro Lys Val Gly Glu Met Ala Thr Phe 
            580                 585                 590         


Leu Ala Arg Asp Ile Asn His Leu Lys Pro Pro Arg Glu Trp Lys Asp 
        595                 600                 605             


Ser Lys Val Arg Leu Asn Asp Glu Gln Tyr Asp Asn Leu Gln Ala Ala 
    610                 615                 620                 


Ile Ser Gln Phe Ser Gly Gln Ile Pro Gln Ile Glu Ala Leu Phe Asp 
625                 630                 635                 640 


Glu Leu Glu Leu Thr Lys Ser Tyr Ser Arg Ser Arg Ala Glu Asn Glu 
                645                 650                 655     


Ala Leu Gln Ala Leu Met His Pro Phe Leu Phe Arg Ile Lys Leu Gln 
            660                 665                 670         


Asp Ser Ala Asn Gln Gly Gly Ile His Ile Phe Tyr Gln Arg Tyr Leu 
        675                 680                 685             


Asn Lys Lys Ala Asp Trp Leu Gln Gly Leu Met Leu Leu Leu Lys Gln 
    690                 695                 700                 


Glu Pro Tyr Gly Asp Phe Gly Pro Phe Asn Asn Phe Pro Glu Gly Tyr 
705                 710                 715                 720 


Gln Asn Ile Ser Leu Pro Glu Phe Thr Lys Lys Phe Asp Tyr Val Leu 
                725                 730                 735     


Arg Ile Asp Lys Lys Leu Asn Arg Lys Lys Gln Tyr Leu Phe Ser Asp 
            740                 745                 750         


Lys Glu Lys Thr Gln Lys Ser Ala Ile Phe Leu Pro Arg Gly Leu Phe 
        755                 760                 765             


Asn Ala Pro Ile Met Glu Ala Leu Phe Phe Lys Lys Asn Ile Glu Val 
    770                 775                 780                 


Glu Pro Asp Asp Ser Leu Val Met Ala Met Ser Lys Tyr Lys Pro Asp 
785                 790                 795                 800 


Ser Gln Ser Phe Tyr Asn Phe Glu Arg Ile Tyr Thr Leu Lys Gly Arg 
                805                 810                 815     


Asp Glu Ala Pro Asp Thr Leu Tyr Thr Gly Asp Ala Asn Gln Ile Gly 
            820                 825                 830         


Ala Gln Met Gln Val Leu Lys Lys Glu Ile Glu Gln Met Gln Ser Lys 
        835                 840                 845             


Arg Lys Ala Met Ser Leu Pro Ala Asp Trp Trp Glu Thr Tyr Ser Gln 
    850                 855                 860                 


Lys Asn Lys Gly Lys Lys Lys Lys Glu Glu Leu Thr Ser Ile Gln Lys 
865                 870                 875                 880 


Thr Ala Gln Asn Leu Glu Tyr Gln Ile Asn Asp Leu Lys Lys Phe Arg 
                885                 890                 895     


Arg Ser Val Met Thr Asn Glu Gln Thr Leu Arg Tyr Arg Gln Thr Asn 
            900                 905                 910         


Asp Arg Val Leu Trp Leu Ile Val Lys Asn Tyr Phe Glu Asp Ile Asp 
        915                 920                 925             


Ser His Phe Asn Ile Asp Ile Ser Glu Trp Glu Leu His Asn Val Gly 
    930                 935                 940                 


Phe Glu Ile Lys Glu Lys Asn Val Leu Asn Thr Lys Ile Asp Leu Ser 
945                 950                 955                 960 


Phe Pro Leu Tyr Gly Tyr Thr Ile His Thr Lys Gln Ser Glu Gly Glu 
                965                 970                 975     


Asn Val Pro Val His Glu Ser Asp His Leu Thr Ile Lys Arg Tyr Gly 
            980                 985                 990         


Glu Phe Arg Tyr Val Leu Lys Asp  Arg Arg Leu Trp Ser  Glu Lys Val 
        995                 1000                 1005             


His Gln  Asp Gly Asn Ile Glu  Lys Thr Gly Ile Leu  Arg Tyr Tyr 
    1010                 1015                 1020             


Ser Pro  Asp Thr Pro Ile Ala  Trp Ser Ile Leu Lys  Arg Glu Leu 
    1025                 1030                 1035             


Asp Thr  Tyr Asp Gly Glu Asp  Arg His Lys Leu Met  Asn His Ile 
    1040                 1045                 1050             


His Ala  Phe Glu Tyr Asp Met  Tyr Thr Met His Glu  Glu Lys Met 
    1055                 1060                 1065             


Glu Arg  Glu Ser Gly Ala Lys  Ile Ile Asn His Leu  Lys Gln Leu 
    1070                 1075                 1080             


Glu Ala  Val His Asn Tyr Ile  Ala Gln Ile Asp Lys  Pro Asn His 
    1085                 1090                 1095             


Leu Met  Ile Asn Glu Leu Arg  Ser Lys Phe Met His  Asn Gln Ile 
    1100                 1105                 1110             


Pro Phe  Asn Ala Trp Leu Glu  Asn Glu Leu Lys Asn  Thr Pro Lys 
    1115                 1120                 1125             


Gly Ser  Lys Val Lys Gln Leu  Leu Asp Ile Ala Thr  Lys Ala Tyr 
    1130                 1135                 1140             


His Asn  Ile Ile Thr Gln Ile  Asn Gln 
    1145                 1150         


<210>  2509
<211>  1147
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2509

Met Thr Glu Gln Asn Glu Lys Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Phe Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Thr His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Asn Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu His Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Tyr Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Glu Lys Val Thr Glu Ala Gly Leu Leu Phe Phe Ala Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Thr Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Ala 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Ser Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Phe Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Glu Glu Ala 
            500                 505                 510         


Ser Ala Glu Arg Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Asp Glu Ile Asp Thr Leu Asp 
    530                 535                 540                 


Arg Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Lys Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Ile Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Gly Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Tyr Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Leu Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Lys Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Asp Leu Glu Ala Trp Ser His Ser Ala Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Val Gly Ile Glu Asn Ala Ser Arg Glu Asn 
    850                 855                 860                 


Lys Thr Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Glu Thr 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Lys Ala Asp Lys Ile Asn Ile Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Ala Lys Glu His Pro Tyr Leu Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Val Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asp Ile Arg Thr 
945                 950                 955                 960 


Asp Val Gln Glu Gln Gly Ser Leu Asn Val Leu Asn His Val Lys Pro 
                965                 970                 975     


Met Arg Leu Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val 
            980                 985                 990         


His Lys Glu Gln Ala Pro Leu Ala  Thr Val Tyr Ile Glu  Glu Arg Asp 
        995                 1000                 1005             


Thr Lys  Leu Leu Lys Gln Gly  Asn Phe Lys Ser Phe  Val Lys Asp 
    1010                 1015                 1020             


Arg Arg  Leu Asn Gly Leu Phe  Ser Phe Val Asp Thr  Gly Gly Leu 
    1025                 1030                 1035             


Ala Met  Glu Gln Tyr Pro Ile  Ser Lys Leu Arg Val  Glu Tyr Glu 
    1040                 1045                 1050             


Leu Ala  Lys Tyr Gln Thr Ala  Arg Val Cys Ala Phe  Glu Gln Thr 
    1055                 1060                 1065             


Leu Glu  Leu Glu Glu Ser Leu  Leu Thr Arg Tyr Pro  His Leu Pro 
    1070                 1075                 1080             


Asp Glu  Asn Phe Arg Lys Met  Leu Glu Ser Trp Ser  Asp Pro Leu 
    1085                 1090                 1095             


Leu Asp  Lys Trp Pro Asp Leu  Gln Arg Glu Val Arg  Leu Leu Ile 
    1100                 1105                 1110             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1115                 1120                 1125             


Glu Thr  Ile Phe Ser Ser Ile  Arg Lys Tyr Asp Pro  Ser Ser Pro 
    1130                 1135                 1140             


Asp Ala  Ile Glu 
    1145         


<210>  2510
<211>  1162
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2510

Met Glu Thr Thr Glu Asn Leu Lys Ser Tyr Asn Cys Gln Asn Ser Phe 
1               5                   10                  15      


Lys Arg Ile Phe Asp Phe Lys Gly Glu Ile Ala Pro Ile Ala Glu Lys 
            20                  25                  30          


Ala Cys Arg Asn Phe Glu Val Lys Ala Lys Asn Lys Val Asn Arg Glu 
        35                  40                  45              


Gln Arg Leu His Tyr Phe Ala Ile Gly His Thr Phe Lys His Ile Asp 
    50                  55                  60                  


Thr Glu Lys Leu Phe Lys Lys Thr Leu Asn Glu Glu Leu Arg Glu Lys 
65                  70                  75                  80  


Ile Pro Thr Gln Phe Leu Ala Leu Gln Ala Phe Asp Lys Ser Phe Cys 
                85                  90                  95      


Asp Glu Leu Glu Lys Ile Ile Ile Asp Lys Asp Asn Lys Lys Lys Tyr 
            100                 105                 110         


Gln Gly Ile Ile Pro Asp Ile Arg Asn Ile Asn Ser His Tyr Val His 
        115                 120                 125             


Asp Phe Gln Asn Ile Arg Leu Asp Thr Leu Ser Ser Cys Met Val Ser 
    130                 135                 140                 


Phe Ile Lys Glu Ser Phe Glu Leu Ala Ile Thr Gln Thr Tyr Leu Lys 
145                 150                 155                 160 


Glu Lys Glu Ile Ser Tyr Thr Gln Leu Ile Glu Gln Gly Asn Val Asp 
                165                 170                 175     


Lys Val Leu Val Ala Phe Met His Asp Lys Phe Tyr Pro Leu Asp Asp 
            180                 185                 190         


Lys Gly Ile Asn Leu Leu Glu Glu Ala Gln Arg Ser Leu Asp Glu Tyr 
        195                 200                 205             


Lys Thr Ile Arg Glu Lys Phe Lys Ser Leu Ser Lys Glu Asp Ala Ile 
    210                 215                 220                 


Asp Ser Leu Leu Phe Val Glu Val Asp Asn Asp Phe Asp Trp Lys Leu 
225                 230                 235                 240 


Tyr Gly Val His Pro Val Phe Lys Ile Thr Thr Gly Lys Tyr Leu Ser 
                245                 250                 255     


Phe Tyr Ala Cys Leu Phe Leu Leu Ser Met Phe Leu Tyr Lys Ser Glu 
            260                 265                 270         


Ala Glu Lys Leu Ile Gly Lys Ile Lys Gly Phe Lys Lys Gln Glu Lys 
        275                 280                 285             


Thr Glu Glu Lys Ser Lys Arg Arg Ile Phe Ser Phe Phe Ser Lys Lys 
    290                 295                 300                 


Phe Ser Ser Gln Asp Ile Asp Ser Glu Glu Asn His Leu Val Lys Phe 
305                 310                 315                 320 


Arg Asp Leu Ile Gln Tyr Leu Asn His Tyr Pro Leu Ala Trp Asn Lys 
                325                 330                 335     


Glu Leu Glu Leu Glu Ser Gln His Pro Ala Met Thr Asp Lys Leu Lys 
            340                 345                 350         


Ala Lys Ile Ile Glu Met Glu Ile Lys Arg Ser Phe Pro Ala Tyr Ser 
        355                 360                 365             


Asn Asn Glu Arg Phe His Val Phe Ala Lys Tyr Gln Ile Trp Gly Lys 
    370                 375                 380                 


Lys Tyr Phe Gly Lys Ser Ile Glu Gln Glu Tyr Ile Glu Gln Ser Phe 
385                 390                 395                 400 


Thr Glu Lys Glu Val Glu Gly Phe Asn Tyr Glu Ile Asp Ala Ser Pro 
                405                 410                 415     


Glu Leu Lys Asp Ala Asn Glu Lys Leu Asp Lys Leu Lys Ala Val Thr 
            420                 425                 430         


Gly Leu Tyr Gly Ala Lys Lys Asp Arg Asn Thr Lys Glu Ile Lys Lys 
        435                 440                 445             


Thr Glu Gly Ile Ile Asn Arg Ile Ile Arg Glu Lys Ala Pro Asn Pro 
    450                 455                 460                 


Val Lys Glu Lys Leu Lys Asn Arg Ile Glu Lys Asn Leu Leu Phe Val 
465                 470                 475                 480 


Ser Tyr Gly Arg Asn Gln Asp Arg Phe Met Asp Phe Ala Ile Arg Tyr 
                485                 490                 495     


Leu Ala Glu Thr Lys Tyr Phe Gly Glu Asp Ala Gln Phe Lys Thr Tyr 
            500                 505                 510         


Arg Phe Tyr Ser Thr Glu Glu Gln Asp Asp Glu Leu Leu Lys Leu Lys 
        515                 520                 525             


Glu Thr Gln Ser Lys Lys Glu Tyr Asp Lys Gln Lys Tyr His Gln Gly 
    530                 535                 540                 


Lys Pro Val His Phe Thr Thr Phe Lys Asp His Leu Glu His Tyr Glu 
545                 550                 555                 560 


Ser Trp Asp Thr Pro Phe Val Ile Glu Asn Asn Ala Val Gln Val Lys 
                565                 570                 575     


Leu Thr Phe Ala Thr Glu Ile Lys Lys Ile Val Ser Val Gln Arg Gly 
            580                 585                 590         


Leu Met Val Tyr Phe Leu Glu Asp Ala Leu Thr Lys Glu Ser Asp Lys 
        595                 600                 605             


Ile Glu Asn Ala Gly Lys Leu Leu Leu Glu Gly Tyr Tyr Ala Phe His 
    610                 615                 620                 


Gln Lys Glu Phe Ser Gln Cys Lys Ser Val Leu Glu Gln Ser Ser Ser 
625                 630                 635                 640 


Ile Ser Pro Glu Glu Lys Thr Ala Phe Lys Lys Leu Leu Pro Lys Arg 
                645                 650                 655     


Leu Leu Tyr His Tyr Ser Pro Ala Val Gln Asn Gly Lys Pro Gln Asn 
            660                 665                 670         


Thr Leu Val Leu Leu Leu Glu Arg Ala Thr Asp Ala Glu Lys Arg Tyr 
        675                 680                 685             


Gly Asn Leu Leu Thr Lys Ala Lys Ala Glu Gly Asn Tyr Asp Asp Phe 
    690                 695                 700                 


Val Lys Cys Asn Lys Gly Lys Gln Phe Lys Leu Gln Phe Ile Arg Lys 
705                 710                 715                 720 


Ala Trp His Leu Met Phe Phe Lys Glu Arg Tyr Met Gln Gln Ala Ala 
                725                 730                 735     


Phe Trp Gly His His Lys Arg Phe His Ile Ala Lys Asp Glu Phe Asn 
            740                 745                 750         


Asp Phe Ser Arg Phe Met Phe Ala Phe Asp Glu Val Pro His Tyr Lys 
        755                 760                 765             


Val Tyr Leu Ala Glu Met Phe Glu Lys Lys Gly Phe Phe Asp Asn Pro 
    770                 775                 780                 


Gly Phe Lys Thr Leu Phe Arg Asp Gly Val Ser Leu Asp Asp Leu Tyr 
785                 790                 795                 800 


Leu Lys Thr Lys Lys Ala Tyr Glu Ala Trp Leu Ser Lys Gln Val Ile 
                805                 810                 815     


Arg Val Gln Glu Glu Asn Lys Tyr Ala Leu Gly Asn Tyr Glu His Phe 
            820                 825                 830         


Phe Asp Asp Glu Met Phe Tyr Ile Asn Ile Ser His Phe Ile Asn Tyr 
        835                 840                 845             


Leu Glu Ala Lys Ser Gly Leu Lys Arg Asp Glu Arg Gly Leu Met Lys 
    850                 855                 860                 


Phe Thr Ala Leu Asp Asn Val Lys Phe Leu Ile Pro Glu Tyr Tyr Tyr 
865                 870                 875                 880 


Ala Asp Lys Leu Glu Lys Ala Glu Tyr Lys Thr Cys Gly Lys Leu Tyr 
                885                 890                 895     


Asn Lys Leu Lys Ser Ser Lys Leu Glu Asp Ala Leu Leu Phe Glu Met 
            900                 905                 910         


Ala Met His Tyr Leu Lys Ile Asp Lys Gln Ile Val Gln Lys Ala Lys 
        915                 920                 925             


Ser His Ala Thr Glu Ile Leu Lys Gln Asp Val Glu Phe Asp Ile Arg 
    930                 935                 940                 


Asp Leu Asn Ser Asn His Leu Tyr His Leu Met Val Pro Phe Asn Lys 
945                 950                 955                 960 


Ile Glu Ser Tyr Ile Gly Leu Ile Lys Leu Lys Glu Glu Gln Glu Glu 
                965                 970                 975     


Ser Lys Phe Lys Thr Ser Phe Leu Ala Asn Ile Val Ser Tyr Ile Glu 
            980                 985                 990         


Leu Val Lys Glu Lys Lys Glu Ile  Lys Ser Ile Tyr Lys  Thr Phe Ser 
        995                 1000                 1005             


Ala Asn  Pro Ala Lys Arg Ile  Leu Thr Phe Asp Glu  Leu Asn Lys 
    1010                 1015                 1020             


Ile Asp  Gly His Leu Ile Ser  Ser Ser Val Lys Phe  Thr Lys Leu 
    1025                 1030                 1035             


Ala Leu  Thr Leu Glu Gln Tyr  Tyr Val Asn Lys Cys  Met Leu Ser 
    1040                 1045                 1050             


Val Ile  Ala Asp His Arg Ile  Glu Tyr Gly Glu Ile  Lys Asp Leu 
    1055                 1060                 1065             


Lys Lys  Tyr Tyr Asn Thr Lys  Thr Arg Asn Lys Ala  Phe His Phe 
    1070                 1075                 1080             


Gly Val  Pro Glu Ser Ser Tyr  Asp Asn Ile Ile Ser  Lys Ile Glu 
    1085                 1090                 1095             


Gln Glu  Phe Val Arg Asn Glu  Ile Lys Ser Thr Gln  Pro His Lys 
    1100                 1105                 1110             


Phe Glu  Glu Leu Ser Lys Pro  Leu Lys Ser Ile Cys  Ser Leu Phe 
    1115                 1120                 1125             


Met Asp  Thr Ile His Asn Asn  Tyr Phe Asp Pro Ile  Glu Arg Asp 
    1130                 1135                 1140             


Gly Lys  Lys Lys His Lys Asp  Ala Glu Gln Lys Tyr  Phe Asp Thr 
    1145                 1150                 1155             


Val Ile  Ser Lys 
    1160         


<210>  2511
<211>  1184
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2511

Met Glu Arg Ile Phe Gly His Cys Cys Pro His His Asp Ser Val Cys 
1               5                   10                  15      


Phe Val Arg Phe Leu Gly Thr Met Val Ser Asn Gln Asp Gly Arg Glu 
            20                  25                  30          


Asn Val Leu Asp Ile Leu Tyr Ile Ala Asp Arg Thr Arg Lys Leu Lys 
        35                  40                  45              


Pro Met Asn Thr Val Pro Ala Ser Glu Asn Lys Gly Gln Ser Arg Thr 
    50                  55                  60                  


Val Glu Asp Asp Pro Gln Tyr Phe Gly Leu Tyr Leu Asn Leu Ala Arg 
65                  70                  75                  80  


Glu Asn Leu Ile Glu Val Glu Ser His Val Arg Ile Lys Phe Gly Lys 
                85                  90                  95      


Lys Lys Leu Asn Glu Glu Ser Leu Lys Gln Ser Leu Leu Cys Asp His 
            100                 105                 110         


Leu Leu Ser Val Asp Arg Trp Thr Lys Val Tyr Gly His Ser Arg Arg 
        115                 120                 125             


Tyr Leu Pro Phe Leu His Tyr Phe Asp Pro Asp Ser Gln Ile Glu Lys 
    130                 135                 140                 


Asp His Asp Ser Lys Thr Gly Val Asp Pro Asp Ser Ala Gln Arg Leu 
145                 150                 155                 160 


Ile Arg Glu Leu Tyr Ser Leu Leu Asp Phe Leu Arg Asn Asp Phe Ser 
                165                 170                 175     


His Asn Arg Leu Asp Gly Thr Thr Phe Glu His Leu Glu Val Ser Pro 
            180                 185                 190         


Asp Ile Ser Ser Phe Ile Thr Gly Thr Tyr Ser Leu Ala Cys Gly Arg 
        195                 200                 205             


Ala Gln Ser Arg Phe Ala Asp Phe Phe Lys Leu Asp Asp Phe Val Leu 
    210                 215                 220                 


Ala Lys Asn Arg Lys Glu Gln Leu Ile Ser Val Ala Asp Gly Lys Glu 
225                 230                 235                 240 


Cys Leu Thr Val Ser Gly Leu Ala Phe Phe Ile Cys Leu Phe Leu Asp 
                245                 250                 255     


Arg Glu Gln Ala Ser Gly Met Leu Ser Arg Ile Arg Gly Phe Lys Arg 
            260                 265                 270         


Thr Asp Glu Asn Trp Ala Arg Ala Val His Glu Thr Phe Cys Asp Leu 
        275                 280                 285             


Cys Ile Arg His Pro His Asp Arg Leu Glu Ser Ser Asn Thr Lys Glu 
    290                 295                 300                 


Ala Leu Leu Leu Asp Met Leu Asn Glu Leu Asn Arg Cys Pro Arg Ile 
305                 310                 315                 320 


Leu Tyr Asp Met Leu Pro Glu Glu Glu Arg Ala Gln Phe Leu Pro Ala 
                325                 330                 335     


Leu Asp Glu Asn Ser Met Asn Asn Leu Ser Glu Asn Ser Leu Asn Glu 
            340                 345                 350         


Glu Ser Arg Leu Leu Trp Asp Gly Ser Ser Asp Trp Ala Glu Ala Leu 
        355                 360                 365             


Thr Lys Arg Ile Arg His Gln Asp Arg Phe Pro Tyr Leu Met Leu Arg 
    370                 375                 380                 


Phe Ile Glu Glu Met Asp Leu Leu Lys Gly Ile Arg Phe Arg Val Asp 
385                 390                 395                 400 


Leu Gly Glu Ile Glu Leu Asp Ser Tyr Ser Lys Lys Val Gly Arg Asn 
                405                 410                 415     


Gly Glu Tyr Asp Arg Thr Ile Thr Asp His Ala Leu Ala Phe Gly Lys 
            420                 425                 430         


Leu Ser Asp Phe Gln Asn Glu Glu Glu Val Ser Arg Met Ile Ser Gly 
        435                 440                 445             


Glu Ala Ser Tyr Pro Val Arg Phe Ser Leu Phe Ala Pro Arg Tyr Ala 
    450                 455                 460                 


Ile Tyr Asp Asn Lys Ile Gly Tyr Cys His Thr Ser Asp Pro Val Tyr 
465                 470                 475                 480 


Pro Lys Ser Lys Thr Gly Glu Lys Arg Ala Leu Ser Asn Pro Gln Ser 
                485                 490                 495     


Met Gly Phe Ile Ser Val His Asp Leu Arg Lys Leu Leu Leu Met Glu 
            500                 505                 510         


Leu Leu Cys Glu Gly Ser Phe Ser Arg Met Gln Ser Asp Phe Leu Arg 
        515                 520                 525             


Lys Ala Asn Arg Ile Leu Asp Glu Thr Ala Glu Gly Lys Leu Gln Phe 
    530                 535                 540                 


Ser Ala Leu Phe Pro Glu Met Arg His Arg Phe Ile Pro Pro Gln Asn 
545                 550                 555                 560 


Pro Lys Ser Lys Asp Arg Arg Glu Lys Ala Glu Thr Thr Leu Glu Lys 
                565                 570                 575     


Tyr Lys Gln Glu Ile Lys Gly Arg Lys Asp Lys Leu Asn Ser Gln Leu 
            580                 585                 590         


Leu Ser Ala Phe Asp Met Asp Gln Arg Gln Leu Pro Ser Arg Leu Leu 
        595                 600                 605             


Asp Glu Trp Met Asn Ile Arg Pro Ala Ser His Ser Val Lys Leu Arg 
    610                 615                 620                 


Thr Tyr Val Lys Gln Leu Asn Glu Asp Cys Arg Leu Arg Leu Arg Lys 
625                 630                 635                 640 


Phe Arg Lys Asp Gly Asp Gly Lys Ala Arg Ala Ile Pro Leu Val Gly 
                645                 650                 655     


Glu Met Ala Thr Phe Leu Ser Gln Asp Ile Val Arg Met Ile Ile Ser 
            660                 665                 670         


Glu Glu Thr Lys Lys Leu Ile Thr Ser Ala Tyr Tyr Asn Glu Met Gln 
        675                 680                 685             


Arg Ser Leu Ala Gln Tyr Ala Gly Glu Glu Asn Arg Arg Gln Phe Arg 
    690                 695                 700                 


Ala Ile Val Ala Glu Leu Arg Leu Leu Asp Pro Ser Ser Gly His Pro 
705                 710                 715                 720 


Phe Leu Ser Ala Thr Met Glu Thr Ala His Arg Tyr Thr Glu Asp Phe 
                725                 730                 735     


Tyr Lys Cys Tyr Leu Glu Lys Lys Arg Glu Trp Leu Ala Lys Thr Phe 
            740                 745                 750         


Tyr Arg Pro Glu Gln Asp Glu Asn Thr Lys Arg Arg Ile Ser Val Phe 
        755                 760                 765             


Phe Val Pro Asp Gly Glu Ala Arg Lys Leu Leu Pro Leu Leu Ile Arg 
    770                 775                 780                 


Arg Arg Met Lys Glu Gln Asn Asp Leu Gln Asp Trp Ile Arg Asn Lys 
785                 790                 795                 800 


Gln Ala His Pro Ile Asp Leu Pro Ser His Leu Phe Asp Ser Lys Val 
                805                 810                 815     


Met Glu Leu Leu Lys Val Lys Asp Gly Lys Lys Lys Trp Asn Glu Ala 
            820                 825                 830         


Phe Lys Asp Trp Trp Ser Thr Lys Tyr Pro Asp Gly Met Gln Pro Phe 
        835                 840                 845             


Tyr Gly Leu Arg Arg Glu Leu Asn Ile His Gly Lys Ser Val Ser Tyr 
    850                 855                 860                 


Ile Pro Ser Asp Gly Lys Lys Phe Ala Asp Cys Tyr Thr His Leu Met 
865                 870                 875                 880 


Glu Lys Thr Val Arg Asp Lys Lys Arg Glu Leu Arg Thr Ala Gly Lys 
                885                 890                 895     


Pro Val Pro Pro Asp Leu Ala Ala Asp Ile Lys Arg Ser Phe His Arg 
            900                 905                 910         


Ala Val Asn Glu Arg Glu Phe Met Leu Arg Leu Val Gln Glu Asp Asp 
        915                 920                 925             


Arg Leu Met Leu Met Ala Ile Asn Lys Met Met Thr Asp Arg Glu Glu 
    930                 935                 940                 


Asp Ile Leu Pro Gly Leu Lys Asn Ile Asp Ser Ile Leu Asp Glu Glu 
945                 950                 955                 960 


Asn Gln Phe Ser Leu Ala Val His Ala Lys Val Leu Glu Lys Glu Gly 
                965                 970                 975     


Glu Gly Gly Asp Asn Ser Leu Ser Leu Val Pro Ala Thr Ile Glu Ile 
            980                 985                 990         


Lys Ser Lys Arg Lys Asp Trp Ser  Lys Tyr Ile Arg Tyr  Arg Tyr Asp 
        995                 1000                 1005             


Arg Arg  Val Pro Gly Leu Met  Ser His Phe Pro Glu  His Lys Ala 
    1010                 1015                 1020             


Thr Leu  Asp Glu Val Lys Thr  Leu Leu Gly Glu Tyr  Asp Arg Cys 
    1025                 1030                 1035             


Arg Ile  Lys Ile Phe Asp Trp  Ala Phe Ala Leu Glu  Gly Ala Ile 
    1040                 1045                 1050             


Met Ser  Asp Arg Asp Leu Lys  Pro Tyr Leu His Glu  Ser Ser Ser 
    1055                 1060                 1065             


Arg Glu  Gly Lys Ser Gly Glu  His Ser Thr Leu Val  Lys Met Leu 
    1070                 1075                 1080             


Val Glu  Lys Lys Gly Cys Leu  Thr Pro Asp Glu Ser  Gln Tyr Leu 
    1085                 1090                 1095             


Ile Leu  Ile Arg Asn Lys Ala  Ala His Asn Gln Phe  Pro Cys Ala 
    1100                 1105                 1110             


Ala Glu  Ile Pro Leu Ile Tyr  Arg Asp Val Ser Ala  Lys Val Gly 
    1115                 1120                 1125             


Ser Ile  Glu Gly Ser Ser Ala  Lys Asp Leu Pro Glu  Gly Ser Ser 
    1130                 1135                 1140             


Leu Val  Asp Ser Leu Trp Lys  Lys Tyr Glu Met Ile  Ile Arg Lys 
    1145                 1150                 1155             


Ile Leu  Pro Ile Leu Asp Pro  Glu Asn Arg Phe Phe  Gly Lys Leu 
    1160                 1165                 1170             


Leu Asn  Asn Met Ser Gln Pro  Ile Asn Asp Leu 
    1175                 1180                 


<210>  2512
<211>  1253
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2512

Met Leu Glu Ile Gln Ile Glu Lys Glu Lys Arg Gly Trp Phe Trp Ala 
1               5                   10                  15      


Met Asn Leu Thr Met Ala Leu Asn Asn Leu Glu Thr Ile Ala Lys Arg 
            20                  25                  30          


Ala Leu Asn Val Leu Gly Lys Pro Tyr Pro Ala Ser Gln Ser Glu Asp 
        35                  40                  45              


Glu Gln Thr Asn Ala Leu Lys Gln Ala Leu Asp Glu Leu Gln Lys Gln 
    50                  55                  60                  


Pro Leu Ile Cys Gln Thr Lys Ile Glu Arg Val Phe Phe Arg Ser Leu 
65                  70                  75                  80  


Pro His Leu Asn Lys Phe Arg Gln Phe Ile Glu Met Gly Gly Glu Lys 
                85                  90                  95      


Ser Ser Ala Ser Tyr Val Glu Lys Ser Ser Ser Arg Ala Asp Ala Glu 
            100                 105                 110         


Ala Thr Gln Arg Gln Ser Gly Arg Asp Phe Thr Ser Asp Asp Leu Phe 
        115                 120                 125             


Gln Leu Ala Arg Tyr Tyr Leu Lys Ser Leu Val Glu Leu Arg Asn Tyr 
    130                 135                 140                 


Phe Ala His Ser Glu His Gln Tyr Pro Lys Leu Pro Glu Ser Leu Asp 
145                 150                 155                 160 


Ile Lys Gly Val Arg Phe Pro Ser Ser Phe Glu Asn Ala Leu Phe Asn 
                165                 170                 175     


Ala Asn Val Arg Thr Val Lys Asp Arg Phe Tyr Lys Asp Asp Arg Lys 
            180                 185                 190         


Asp Ala Arg Glu Ile Glu Asn Gly Phe Leu Cys Phe Arg Pro Lys Lys 
        195                 200                 205             


Thr Val Lys Asn Arg Glu Thr Val Asp Asn Pro Glu Phe Lys Phe Arg 
    210                 215                 220                 


Leu Thr Glu Arg Asn Asp Ala Asn Gly Arg Arg Tyr Pro Thr Gln Ala 
225                 230                 235                 240 


Gly Leu Ala Phe Phe Val Ala Arg Phe Leu Glu Lys Arg Tyr Val Asp 
                245                 250                 255     


Leu Leu Phe Glu Thr Thr Asp Ala Asn Gly Val Pro Val Leu Pro Leu 
            260                 265                 270         


His Arg Pro Gln Asp Val Asp Gly Val Glu Phe Ser Leu Ala Pro Arg 
        275                 280                 285             


Arg Val Tyr Gly Leu Asn Ala Ala Arg Leu Pro Arg Arg Arg Val Glu 
    290                 295                 300                 


Thr Thr Ala Arg Pro Glu Ser Ser Asn Glu Thr Leu Gly Leu Asp Leu 
305                 310                 315                 320 


Ile Gly Tyr Leu Ala Arg Cys Pro Lys Arg Val Tyr Glu Phe Leu Ser 
                325                 330                 335     


Glu Thr Asp Arg Arg Lys Phe Arg Val Ala Ala Asp Glu Ser Asn Pro 
            340                 345                 350         


Ser Glu Gly Leu Arg Thr Arg Ser Glu Lys Arg Phe Ala Arg Leu Ala 
        355                 360                 365             


Ala Leu Cys Leu Asp Arg Met Asn Cys Phe Glu Asn Leu Arg Phe Gln 
    370                 375                 380                 


Val Asp Met Gly Gln Tyr Tyr Ser Ala Thr His Arg Arg Arg Leu Ile 
385                 390                 395                 400 


Asp Gly Thr Thr Ile Asp Asp Arg Arg Val Gly Lys Arg Val Phe Trp 
                405                 410                 415     


Phe Glu Arg Ile Gln Asn Ala Val Asp Tyr Tyr Arg Ala Glu Arg Leu 
            420                 425                 430         


Lys Pro Glu Ser Lys Tyr Phe Val Pro Thr Asp Glu Ala Glu Thr Pro 
        435                 440                 445             


Pro Glu Thr Asp Tyr Arg Val Asp Ala Tyr Pro Arg Tyr Arg Val Lys 
    450                 455                 460                 


Asn Gln Gln Leu Gly Leu Arg Leu Val Asp Ala Ser Gln Lys Asn Ala 
465                 470                 475                 480 


Pro Pro Lys Leu Ile Pro Trp Thr His Ser Ala Lys Arg Gly Ser Ala 
                485                 490                 495     


Pro Lys Thr Arg Met Lys Arg Pro Glu Phe Trp Leu Ser Gln Tyr Glu 
            500                 505                 510         


Leu Pro Ala Leu Leu Phe Val Ala Leu His Gly Lys Ala Gln Asp Ala 
        515                 520                 525             


Gln Asn Val Ile Ala Asp Tyr Gln Lys Asn Trp Arg Arg Phe Leu Glu 
    530                 535                 540                 


Asp Val Arg Asp Gly Lys Phe Asp Phe Gly Gly Gly Arg Ala Leu Arg 
545                 550                 555                 560 


Glu Thr Arg Gln Thr Phe Glu Ser Gln Tyr Gly Leu Arg Phe Asp Asp 
                565                 570                 575     


Leu Pro Asp Ser Thr Arg Ala Leu Phe Arg Ser Thr Ala Ser Asp Ser 
            580                 585                 590         


Lys Glu Leu Glu Lys Lys Arg Val Asp Ala Ala Glu Gln Thr Leu Pro 
        595                 600                 605             


Glu Arg Gln Ile Asp Arg Leu Leu Asp Glu Thr Arg Arg Arg Leu Ala 
    610                 615                 620                 


Val Leu Glu Ser Glu Thr Arg Glu Val Phe Gln Leu Gly Lys Arg Lys 
625                 630                 635                 640 


Arg Pro Ser Leu Ser Val Gly Arg Val Ala Ser Cys Leu Val Arg Asp 
                645                 650                 655     


Leu Met Arg Phe Gln Tyr Ala Thr Ser Glu Lys Ser Phe Gly Lys Ile 
            660                 665                 670         


Pro Ser Ser Pro Asp Phe Ile Ala Leu Gln Thr Ser Leu Ala Cys Phe 
        675                 680                 685             


Glu Ser Arg Gln Asn Glu Leu Leu Glu Ile Phe Lys Ala Ala Lys Leu 
    690                 695                 700                 


Ile Pro Ser Asn Phe Val Ala Pro Asn Asp Ala Glu Glu Ala Phe Phe 
705                 710                 715                 720 


Phe Ala Asp Ala Gln Asn Ala Glu Arg Ser Leu His Pro Phe Leu Gly 
                725                 730                 735     


Ala Val Val Ala Asp Ala Ala Asn Leu Arg Asp Trp Lys Ser Phe Tyr 
            740                 745                 750         


Arg Ala Tyr Leu Thr Cys Arg Leu Asn Trp Leu Arg Gly Cys Ala Pro 
        755                 760                 765             


Gln Glu Leu Arg His Thr Arg Tyr Gly Asn Arg Arg Leu Glu Lys Leu 
    770                 775                 780                 


Lys Lys Met Arg Lys Ser Gly Lys Arg Gln Thr Val Ala Gln Gln Met 
785                 790                 795                 800 


Ala Thr Arg Leu Leu Glu Gln Pro Ile Asn Leu Pro Arg Gly Leu Phe 
                805                 810                 815     


Thr Asp Leu Val Arg Ala Val Val Gln Glu Arg Phe Gly Asp Gln Leu 
            820                 825                 830         


Ala Lys Ala Thr Gln Asn Gly Ala Thr Ser Thr Asn Ala Ser Trp Leu 
        835                 840                 845             


Ile Gly Lys Val Arg Asp Trp Ser Asp Asp Ala Ser Gln Gly Phe Tyr 
    850                 855                 860                 


Ser Trp Arg Arg Asp Tyr Arg Asn Val Ala Ser Phe Lys Arg Leu Phe 
865                 870                 875                 880 


Glu Leu Cys Gly Pro Thr Val Ser Thr Ser Pro Leu Ala Phe Arg Ala 
                885                 890                 895     


Leu Asn Ser Thr Ser Pro Leu Asp Phe Arg Ala Leu Lys Glu Ala Phe 
            900                 905                 910         


Asp Ala Asn Phe Asp Ala Asn Tyr Ala Ala Ala Glu Phe Ala Lys Thr 
        915                 920                 925             


Asp His Lys Thr Asp Arg Glu Asp Trp Glu Arg Phe Ile Arg Glu Ala 
    930                 935                 940                 


Glu Ala Glu Leu Arg Glu Glu Ala Leu Glu Ala Thr Arg Gly Arg Ser 
945                 950                 955                 960 


Gln Arg Arg Pro Phe Ile Pro Arg Glu Lys Ile Glu Glu Arg Ala Ser 
                965                 970                 975     


Lys Lys Arg Lys Lys Phe Ala Asp Glu Gln Lys Ala Lys Arg Arg Ala 
            980                 985                 990         


Ala Glu His Ala Lys Ile Arg Arg  Leu Ser Asp Ala Glu  Arg Asp Ile 
        995                 1000                 1005             


Arg His  Ala Glu Ile Gln Asp  Tyr Val Leu Leu Leu  Ala Ala Ser 
    1010                 1015                 1020             


Tyr Phe  Leu Phe Glu Gly Asp  Leu Ala Lys Ile Arg  Leu Ala Asp 
    1025                 1030                 1035             


Val Tyr  Ala Ile Val Asp Asp  Ala Thr Gly Thr Val  Ser Thr Asn 
    1040                 1045                 1050             


Pro Leu  Arg Lys Leu Arg Pro  Cys Glu Val Leu Val  Asp Val Pro 
    1055                 1060                 1065             


Gly Ser  Gly Thr Cys Lys Ile  Arg Gly Glu Met Asn  Val Lys Asn 
    1070                 1075                 1080             


Ser Gly  Asn Phe Gln Arg Phe  Leu Thr Asp Gly Arg  Leu Pro Ser 
    1085                 1090                 1095             


Phe Leu  Arg Ser Leu Arg Leu  Met Gln Ala Glu Asn  Ala Glu Glu 
    1100                 1105                 1110             


Leu Ser  Tyr Ile Asp Leu Ala  Asn Glu Phe Ala Ala  Ser Asp Arg 
    1115                 1120                 1125             


Leu Gln  Arg Gly Arg Ile Phe  Ala Ala Ile Tyr Arg  Phe Glu Asn 
    1130                 1135                 1140             


Ala Cys  Phe Ser Val Phe Pro  Glu Leu Lys Asp Lys  Lys Arg Gly 
    1145                 1150                 1155             


Gly Tyr  Val Ser Phe Ala Thr  Ile Leu Thr Ser Val  Phe Pro Asn 
    1160                 1165                 1170             


Asp Glu  Glu Thr Gln Tyr Arg  Leu Leu Val Ile Arg  Asn Lys Phe 
    1175                 1180                 1185             


Met His  Gln Glu Tyr Pro Ile  Tyr Asp Ala Ser Gln  Thr Lys Asp 
    1190                 1195                 1200             


Lys Gln  Arg Trp Thr Pro Ile  Phe Asp Arg Trp Asn  Arg Glu Met 
    1205                 1210                 1215             


Trp Ala  Lys Tyr Asp Pro Lys  His Gly Arg Ala Leu  Cys Gln Cys 
    1220                 1225                 1230             


Ala Val  Asp Trp Ala Glu Pro  Tyr Phe Asp Glu Ala  Thr Lys Leu 
    1235                 1240                 1245             


Val Glu  Ser Arg Arg 
    1250             


<210>  2513
<211>  1145
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2513

Met Glu Thr Leu Thr Ile Pro Glu Val Ile Lys Cys Arg Thr Leu Ser 
1               5                   10                  15      


Asp Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Ile Ala Lys Glu Phe Asp Leu Pro Leu 
        35                  40                  45              


Leu Ala Glu Glu Gly His Leu Lys Asn Ser Phe Leu Cys Lys Lys Glu 
    50                  55                  60                  


His Asn Lys Val Asn Trp Asn His Val Tyr Ser Arg Thr Lys Arg Phe 
65                  70                  75                  80  


Leu Ala Val Leu Lys Val Phe Asp Ala Glu Thr Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Lys Thr Ile Asn Trp Glu Gly Lys Asp Phe Ala Ser Met Ser Asp 
            100                 105                 110         


Ile Leu Lys Ile Val Phe Gly Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Thr Ile Arg Lys Thr Ala Val 
    130                 135                 140                 


Ser Ala Glu Met Ala Leu Phe Leu Thr Thr Asn Phe Arg Arg Ala Ile 
145                 150                 155                 160 


Glu Tyr Thr Lys Glu Arg Phe Lys Gly Val Leu Asn Asp Glu Asp Tyr 
                165                 170                 175     


Gln Leu Val Ala Ser Lys Lys Val Leu Glu Ala Asn Ser Thr Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Arg Phe Ile Gly Ile Ile Thr Gly Leu Lys Gly Thr Gln Asn 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro His Asp Arg Phe Gln Ser Asp Asn Pro Arg Gln Ala Phe Ser 
                245                 250                 255     


Leu Asp Leu Ile Asn Glu Leu Asn Arg Cys Pro Lys Val Leu Tyr Asn 
            260                 265                 270         


Ala Ile Thr Glu Glu Gly Lys Gln Lys Leu Arg Ser Ile Pro Gly Glu 
        275                 280                 285             


Leu Glu Asn Lys Asn Leu His Asp Asn Asn Thr Lys Lys Glu Ala Lys 
    290                 295                 300                 


Ile Glu Ala Glu Ala Tyr Glu Leu Tyr Ile Glu Ser Leu Thr Arg Gln 
305                 310                 315                 320 


Ile Arg Tyr Ser Asn Arg Phe Pro Asp Phe Ala Leu Lys Phe Ile Asp 
                325                 330                 335     


Glu Thr Asp Ile Phe Ser Glu Phe Arg Phe Gln Ile Asp Leu Gly Lys 
            340                 345                 350         


Leu Leu Val Asp Glu Tyr Leu Lys Phe Phe Asn Gly Glu His Val Gln 
        355                 360                 365             


Arg Arg Ile Val Glu Asn Ala Lys Ala Phe Gly Lys Leu Ile Asp Phe 
    370                 375                 380                 


Asn Asp Glu Ala Lys Val Met Thr Arg Ile Gly Asn Gly His Phe Ser 
385                 390                 395                 400 


Lys Arg Phe Glu Gln Phe Ala Pro Phe Tyr Asn Thr Glu Asp Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Arg His His Val Thr Ala Lys Leu Gly Pro Asp Ser 
            420                 425                 430         


Lys Gly Glu Pro Glu Lys Lys Leu Leu Gln Pro Leu Pro Glu Ala Phe 
        435                 440                 445             


Leu Ser Leu His Glu Leu Pro Lys Val Ile Leu Leu Asp Tyr Leu Gln 
    450                 455                 460                 


Lys Gly Glu Pro Glu Lys Leu Ile Asn Asp Phe Ile Leu Ile Asn Asn 
465                 470                 475                 480 


Ser Lys Leu Met Asn Met Ser Phe Ile Glu Ala Val Lys Thr Gln Leu 
                485                 490                 495     


Pro Pro Glu Trp Asp Glu Phe Gln Arg Arg Thr Gly Ser Lys Asn Glu 
            500                 505                 510         


Met Pro Tyr Asn Glu Lys Thr Leu Ala Tyr Leu Leu Gln Arg Lys Gln 
        515                 520                 525             


Ile Leu Asn Lys Ile Leu Ala Glu Phe Gln Leu Asn Asp Lys Gln Ile 
    530                 535                 540                 


Pro Gly Arg Ile Leu Asp Tyr Trp Leu Asn Ile Ala Asp Val Glu Glu 
545                 550                 555                 560 


Glu Arg Ala Val Ser Asp Arg Ile Lys Ser Ile Lys Arg Asp Cys Met 
                565                 570                 575     


Ser Arg Leu Arg Ala Leu Gly Lys Phe Lys Ile Asp Arg Asn Arg Asn 
            580                 585                 590         


Lys Ile Pro Lys Ile Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile 
        595                 600                 605             


Val Asp Met Val Val Ser Glu Gly Lys Lys His Lys Ile Thr Ser Phe 
    610                 615                 620                 


Tyr Tyr Glu Lys Met Gln Asp Cys Leu Ser Leu Phe Ala Asp Pro Leu 
625                 630                 635                 640 


Lys Arg Gln Leu Phe Ile His Ile Ile Thr Asn Glu Leu Arg Leu Asn 
                645                 650                 655     


Asp Ser Gly Gly His Pro Phe Leu Phe Lys Leu Asn Met Arg Gln Ile 
            660                 665                 670         


Asn Cys Thr Ser Asp Phe Tyr Glu Ile Tyr Leu Gln Glu Lys Gly His 
        675                 680                 685             


Lys Met Val Pro Glu Lys Asn Leu Lys Thr Gly Lys Val Val Asn Thr 
    690                 695                 700                 


Asp His Ser Trp Met Ala Leu Thr Phe Tyr Lys Leu Glu Phe Asn Asp 
705                 710                 715                 720 


Lys Val Asp Lys Leu Met Thr Val Val Lys Leu Pro Leu Asn Lys Leu 
                725                 730                 735     


Asn Leu Pro Phe Thr Leu Arg Gln Leu Asn Ala Lys Thr Thr Tyr Thr 
            740                 745                 750         


Leu Glu Gln Trp Leu Lys Asn Leu Thr Leu Gly Lys Lys Pro Asp Asp 
        755                 760                 765             


Gly Lys His Pro Val Asn Leu Pro Thr Asn Leu Phe Asp Glu Lys Leu 
    770                 775                 780                 


Ser Asp Leu Leu Arg Gln Asp Leu Asp Asn Asn Lys Ile Ala Tyr Arg 
785                 790                 795                 800 


Pro Tyr Ala Asn Trp Asn Glu Leu Phe Lys Ile Trp Trp Ile Ser Arg 
                805                 810                 815     


Asn Asp Ser Leu Gln Arg Phe Tyr Asn Ala Glu Arg Glu Tyr His Ile 
            820                 825                 830         


Phe Asn Glu Lys Val Asn Phe Tyr Pro Asn Arg Lys Glu Asn Phe Ala 
        835                 840                 845             


Asp Tyr Tyr Gln His Ala Val Lys Val Ala Phe Gln Lys Lys Arg Asn 
    850                 855                 860                 


Glu Arg Ile Ile Glu Gln Arg Ile Asn Lys Tyr Leu Pro Asp Ile Leu 
865                 870                 875                 880 


Phe Glu Gln Val Glu Lys Thr Phe Lys His Thr Ile Ala Glu Thr Glu 
                885                 890                 895     


Lys Glu Ile Arg Ile Leu Gln Glu Glu Asp Arg Ile Met Leu Leu Met 
            900                 905                 910         


Leu Glu Gly Leu Met Glu Asp Gly Asn Lys Gln Gln Leu Lys Leu Ser 
        915                 920                 925             


Glu Ile Lys Thr Leu Gln Asn Ala Thr Ile Asn Ile Arg Gln Leu Val 
    930                 935                 940                 


Pro Gly Lys Leu Ser Phe Asp Asp Ser Gly Glu Ala Ile Lys Asp Ser 
945                 950                 955                 960 


Thr Asn Pro Glu Ile Val Arg Thr Val Ser Val Ser Ile Lys Arg Ile 
                965                 970                 975     


Glu Tyr Asn Leu Leu Pro Lys Tyr Val Ala Asp Gly Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Pro Asp Glu  Glu Ile Gln Met Glu  Arg Leu Lys 
        995                 1000                 1005             


Thr Glu  Phe Asp Thr Tyr Asn  Lys Val Arg Gln Val  Val Leu Asp 
    1010                 1015                 1020             


Leu Ser  Phe Lys Leu Glu Lys  Met Ile Ile Glu Lys  Gly His Lys 
    1025                 1030                 1035             


Asp Arg  Ile Asn Gln Leu Cys  Thr Gly Ala Thr Gly  Glu Leu Leu 
    1040                 1045                 1050             


Thr Gly  Asn Ile Cys His His  Thr Tyr Leu Thr Trp  Leu Lys Asp 
    1055                 1060                 1065             


Lys Glu  Met Ile Asp Asn Glu  Thr Phe Ile Phe Met  Asn Met Val 
    1070                 1075                 1080             


Gln His  Cys Phe Ser His Asn  Gln Tyr Pro Gln Lys  Lys Thr Met 
    1085                 1090                 1095             


Glu Arg  Ile Ile Asn His Trp  Glu Pro Asp Arg Phe  Ala Leu Thr 
    1100                 1105                 1110             


Ile Ala  Ala Thr Tyr Asn Gln  Lys Ile Ala Gly Ile  Leu Glu Asp 
    1115                 1120                 1125             


Ile Gly  Thr Phe Pro Phe Ile  Arg Ser Arg Lys Thr  Met Pro Asp 
    1130                 1135                 1140             


Val Val  
    1145 


<210>  2514
<211>  1132
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2514

Met Lys Glu Glu Glu Lys Gly Lys Thr Pro Val Val Ser Thr Tyr Asn 
1               5                   10                  15      


Lys Asp Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His 
            20                  25                  30          


Asn Val Tyr Ile Thr Ile Asn His Ile Asn Lys Leu Leu Glu Ile Arg 
        35                  40                  45              


Glu Ile Asp Asn Asp Glu Lys Val Leu Asp Ile Lys Ala Leu Trp Gln 
    50                  55                  60                  


Lys Gly Asn Lys Asp Leu Asn Gln Lys Ala Arg Leu Arg Glu Leu Met 
65                  70                  75                  80  


Thr Lys His Phe Pro Phe Leu Glu Thr Ala Ile Tyr Thr Lys Asn Lys 
                85                  90                  95      


Glu Asp Lys Lys Glu Val Lys Gln Glu Lys Gln Ala Glu Ala Gln Ser 
            100                 105                 110         


Leu Glu Ser Leu Lys Asp Cys Leu Phe Leu Phe Leu Glu Lys Leu Gln 
        115                 120                 125             


Glu Ala Arg Asn Tyr Tyr Ser His Tyr Lys Tyr Ser Glu Ser Thr Lys 
    130                 135                 140                 


Glu Pro Met Leu Glu Glu Gly Leu Leu Glu Lys Met Tyr Asn Ile Phe 
145                 150                 155                 160 


Asp Asp Asn Ile Gln Leu Val Ile Lys Asp Tyr Gln His Asn Lys Asp 
                165                 170                 175     


Ile Asn Pro Asp Glu Asp Phe Lys His Leu Asp Arg Lys Gly Gln Phe 
            180                 185                 190         


Lys Tyr Ser Phe Ala Asp Asn Glu Gly Asn Ile Thr Glu Ser Gly Leu 
        195                 200                 205             


Leu Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Met 
    210                 215                 220                 


Gln Gln Lys Leu Arg Gly Phe Lys Asp Asn Arg Glu Ser Lys Lys Lys 
225                 230                 235                 240 


Met Thr His Glu Val Phe Cys Arg Ser Arg Met Leu Leu Pro Lys Leu 
                245                 250                 255     


Arg Leu Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu 
            260                 265                 270         


Asn Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Lys Gly 
        275                 280                 285             


Glu Asp Arg Lys Lys Phe Glu Val Pro Phe Asp Ser Thr Asp Glu Asp 
    290                 295                 300                 


Tyr Asp Ala Glu Gln Asp Pro Phe Lys Asn Thr Leu Ile Arg His Gln 
305                 310                 315                 320 


Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Tyr Asn Glu Ile 
                325                 330                 335     


Phe Ala Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser 
            340                 345                 350         


Ile Tyr Lys Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg His Leu Thr 
        355                 360                 365             


His Lys Leu Tyr Gly Phe Glu Arg Ile Gln Glu Phe Ala Lys Gln Asn 
    370                 375                 380                 


Arg Thr Asp Glu Trp Lys Ala Leu Val Lys Asp Leu Asp Thr Tyr Glu 
385                 390                 395                 400 


Thr Ser Asn Glu Arg Tyr Ile Ser Glu Thr Thr Pro His Tyr His Leu 
                405                 410                 415     


Glu Asn Gln Lys Ile Gly Ile Arg Asn Lys Lys Lys Lys Lys Lys Lys 
            420                 425                 430         


Asn Ile Trp Pro Ser Leu Glu Thr Asn Thr Thr Val Asn Glu Lys Ser 
        435                 440                 445             


Lys Tyr Asn Leu Gly Lys Ser Phe Lys Ala Lys Ala Phe Leu Ser Val 
    450                 455                 460                 


His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Thr Lys Glu 
465                 470                 475                 480 


Glu Pro Asn Asn Lys Glu Ile Asn Ala Ser Lys Val Glu Gly Ile Ile 
                485                 490                 495     


Glu Lys Lys Ile Arg Asp Met Tyr Lys Leu Tyr Glu Ala Phe Ala Asn 
            500                 505                 510         


Gly Glu Ile Asn Ser Glu Asp Asp Leu Lys Lys Tyr Cys Lys Gly Lys 
        515                 520                 525             


Asp Ile Glu Met Val His Leu Pro Lys Gln Met Val Ala Ile Leu Lys 
    530                 535                 540                 


Asn Lys Pro Lys Asp Val Ala Glu Glu Ala Lys His Lys Gln Lys Lys 
545                 550                 555                 560 


Met Val Lys Ala Ala Glu Cys Lys Gln Arg Lys Met Val Lys Asp Thr 
                565                 570                 575     


Glu Lys Leu Leu Ala Ala Leu Glu Lys Gln Thr Gln Glu Glu Ile Glu 
            580                 585                 590         


Asp Gly Gly Arg Asn Ile Arg Leu Leu Lys Ser Gly Glu Ile Ala Arg 
        595                 600                 605             


Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln Lys Asp Asn 
    610                 615                 620                 


Glu Gly Asn Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln 
625                 630                 635                 640 


Met Leu Gln Arg Ser Leu Ala Leu Tyr Asn Lys Glu Glu Lys Pro Thr 
                645                 650                 655     


Arg Tyr Phe Lys Gln Val Asn Leu Ile Glu Ser Gly Asn Pro His Pro 
            660                 665                 670         


Phe Leu Asn Asn Thr Gly Trp Lys Glu Cys Asn Asn Ile Leu Ser Phe 
        675                 680                 685             


Tyr Arg Ser Tyr Leu Thr Lys Lys Ile Glu Phe Leu Asn Glu Leu Lys 
    690                 695                 700                 


Pro Glu Asp Trp Glu Lys Asn Gln Tyr Phe Leu Lys Leu Lys Glu Pro 
705                 710                 715                 720 


Lys Thr Asn Arg Glu Thr Leu Val Gln Gly Trp Lys Asn Gly Phe Asn 
                725                 730                 735     


Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg Glu Trp Phe Lys Arg 
            740                 745                 750         


His Gln Asn Asp Ser Glu Glu Tyr Lys Lys Val Glu Ala Leu Lys Arg 
        755                 760                 765             


Val Gly Leu Val Thr Lys Val Ile Pro Leu Phe Phe Lys Glu Glu Tyr 
    770                 775                 780                 


Ser Lys Asp Asp Ala Gln Lys Glu Ile Asn Asn Cys Val Gln Pro Phe 
785                 790                 795                 800 


Tyr Ser Leu Pro Tyr Asn Val Gly Asn Ile His Lys Pro Asp Glu Lys 
                805                 810                 815     


Asp Phe Leu His Arg Glu Glu Arg Ile Glu Leu Trp Gly Lys Lys Lys 
            820                 825                 830         


Asp Lys Phe Lys Gly Tyr Lys Ala Lys Lys Lys Pro Lys Lys Ile Thr 
        835                 840                 845             


Asp Glu Val Lys Glu Glu His Arg Ser Tyr Leu Glu Phe Gln Ser Trp 
    850                 855                 860                 


Asn Lys Phe Glu Arg Glu Leu Arg Leu Val Arg Asn Gln Asp Ile Val 
865                 870                 875                 880 


Thr Trp Leu Leu Cys Met Glu Leu Phe Asp Asn Leu Lys Val Glu Gly 
                885                 890                 895     


Leu Asn Val Glu Glu Leu Gln Lys Leu Arg Leu Lys Asp Ile Asp Thr 
            900                 905                 910         


Asp Thr Ala Lys Lys Asp Lys Asn Asn Ile Leu Asn Arg Ile Met Pro 
        915                 920                 925             


Met Gln Leu Pro Val Thr Val Tyr Glu Ile Asp Asp Ser His Asn Ile 
    930                 935                 940                 


Val Lys Asp Arg Pro Leu His Ser Val Tyr Ile Glu Glu Thr Lys Thr 
945                 950                 955                 960 


Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys Asp Arg Arg 
                965                 970                 975     


Leu Asn Gly Leu Phe Ser Phe Val Asp Thr Ser Ser Glu Ala Glu Leu 
            980                 985                 990         


Lys Ser Lys Pro Ile Ser Lys Ser  Val Val Glu Tyr Glu  Leu Gly Glu 
        995                 1000                 1005             


Tyr Gln  Asn Ala Arg Ile Glu  Thr Ile Lys Asp Met  Leu Leu Leu 
    1010                 1015                 1020             


Glu Glu  Thr Leu Ile Lys Lys  Tyr Lys Lys Leu Pro  Thr Asp Asn 
    1025                 1030                 1035             


Phe Ser  Asp Met Leu Asn Gly  Trp Leu Lys Gly Lys  Asp Glu Ala 
    1040                 1045                 1050             


Asp Lys  Ala Arg Phe Gln Asn  Asp Val Lys Leu Leu  Val Ala Val 
    1055                 1060                 1065             


Arg Asn  Ala Phe Ser His Asn  Gln Tyr Pro Met Arg  Asn Arg Ile 
    1070                 1075                 1080             


Ala Phe  Ala Asn Ile Asn Pro  Phe Ser Leu Ser Ser  Ala Asp Thr 
    1085                 1090                 1095             


Ser Glu  Glu Lys Lys Leu Asp  Ile Ala Asn Gln Leu  Lys Asp Lys 
    1100                 1105                 1110             


Thr Lys  Glu Thr Ile Asp Lys  Ile Ile Glu Ile Glu  Lys Pro Ile 
    1115                 1120                 1125             


Glu Thr  Lys Glu 
    1130         


<210>  2515
<211>  1029
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2515

Met His Val Thr Thr Thr Asn Lys Pro Leu Leu Ala Ala Tyr Leu Asn 
1               5                   10                  15      


Met Ala Arg Asn Asn Cys Tyr Met Ala Leu Ser His Ile Ala Glu Leu 
            20                  25                  30          


Met Gly Lys Ser Ser Val Met Asn Glu Asp Ala Ile Gln Glu Cys Ala 
        35                  40                  45              


Val Ile Arg Ala Leu Ala Gly Asn Ile Lys Pro Asp Glu Ser Phe Arg 
    50                  55                  60                  


Ile Ile Asp Met Val Asp Gln His Phe Pro Phe Ile Arg Leu Leu Leu 
65                  70                  75                  80  


Lys Ser Arg Asn Asn Ser Ser Pro Thr Asp Tyr Ala Asn Cys Leu Thr 
                85                  90                  95      


Asp Phe Ile Lys Gln Leu Asn Glu Leu Arg Asn Phe His Thr His Gln 
            100                 105                 110         


Leu His Lys Pro Tyr Ile Thr Asp Ala Lys Val Val Ala Gln Leu Gln 
        115                 120                 125             


Phe Leu Phe Asp Ala Ser Arg Arg Glu Val Lys Lys Arg Phe Ser Leu 
    130                 135                 140                 


Glu Glu Gln Asp Val Lys His Leu Val Arg Lys Ser Ile Val Ile Ile 
145                 150                 155                 160 


Asp Asn Asn Lys Val Ala Val Glu Lys Glu Asn Tyr Val Tyr Ala Phe 
                165                 170                 175     


Ala Asn Lys Glu Gly Gln Phe Thr Asn Lys Gly Ile Ala Phe Leu Ile 
            180                 185                 190         


Ser Leu Phe Ile Glu Lys Lys Tyr Ala Tyr Leu Phe Leu Lys Gln Leu 
        195                 200                 205             


Ser Gly Phe Lys Asn Ser Asn Thr Lys Gln His Lys Ala Thr Leu Glu 
    210                 215                 220                 


Val Phe Cys Phe Tyr His Ile Arg Ile Pro Gln Pro Lys Leu Gln Ser 
225                 230                 235                 240 


Asn Asn Thr Lys Ile Gly Phe Leu Leu Asp Ala Leu Glu Glu Leu Lys 
                245                 250                 255     


Arg Cys Pro Ala Glu Leu Tyr Glu His Ile Ala Lys Asn Asp Lys Gln 
            260                 265                 270         


Arg Phe Lys Ser Ala Gly Ile Thr Glu Asp Thr Asn Asp Gln Pro Glu 
        275                 280                 285             


Ala Ile Leu Lys Arg Asn Gly Asp Arg Phe Ser Tyr Leu Ala Leu Arg 
    290                 295                 300                 


Tyr Leu Glu Leu Thr Asn Ser Leu Pro Gly Leu Gln Phe Tyr Phe Asp 
305                 310                 315                 320 


Leu Gly Lys Tyr Tyr Phe Lys Val Tyr Glu Lys Ser Ile Asp Ser Glu 
                325                 330                 335     


Leu Arg Leu Arg Arg Leu His Lys Asn Met Arg Asp Phe Gly Arg Thr 
            340                 345                 350         


Asn Asp Phe Asp Thr Val Lys Met Pro Gln Leu Trp Gln Gln Leu Ile 
        355                 360                 365             


Lys Arg Thr Asp Glu Leu Ser Glu Asn Tyr Ala Glu Pro Tyr Ile Val 
    370                 375                 380                 


Tyr Thr Ile Pro His Tyr His Ile Val Asn Asn Gln Ile Gly Ile Trp 
385                 390                 395                 400 


Leu Asn Lys Glu Arg Gln Met Pro Ser Leu Thr Pro Lys Ile Ser Asn 
                405                 410                 415     


Ala Glu Pro Gln Ile Trp Leu Ser Leu Tyr Glu Leu Pro Ala Leu Leu 
            420                 425                 430         


Phe Tyr His Leu Leu Thr Lys Gly Asn Lys Gly Gln Lys Asn Val Leu 
        435                 440                 445             


Gln Ile Leu Ser Lys His Arg Thr Ala Ile His Ser Phe Phe Lys Asp 
    450                 455                 460                 


Ile Glu Ser Ser Lys Leu Leu Pro Gly Phe Thr Ile Glu Thr Leu Asn 
465                 470                 475                 480 


Val Glu Leu Glu Lys Arg Asn Leu Lys His Asp Lys Ile Pro Lys Pro 
                485                 490                 495     


Leu Leu Gln Tyr Leu Leu Gln Gln Lys Pro Leu Lys Ser Ile Val Glu 
            500                 505                 510         


Ile Ala Gly Glu Arg Leu Ser Glu Leu Gln Asn Glu Thr Ile Phe Leu 
        515                 520                 525             


Leu Asp Lys Ile Asp Ile Asp Ile Glu Lys Ala Lys Glu Lys Ile Gly 
    530                 535                 540                 


Gly Lys His Tyr Arg Pro Ile Gln Thr Gly Lys Ile Ala Asp Phe Leu 
545                 550                 555                 560 


Ala Arg Asp Met Leu Phe Phe Gln Pro Ala Ile Asp Lys Ile Lys Gly 
                565                 570                 575     


Lys Ala Thr Ser Thr Leu Phe Gln Val Leu Gln Ala Arg Leu Ala Phe 
            580                 585                 590         


Tyr Gly Arg Asp Lys Glu Leu Leu Glu Gly Leu Tyr Lys Glu Cys Asn 
        595                 600                 605             


Leu Ile Gln Ser Lys Asn Pro His Pro Phe Leu Ser Gly Leu Pro Ile 
    610                 615                 620                 


Thr Asn Asn Leu Met Asp Tyr Tyr Arg Asn Tyr Leu Ile Lys Arg Asn 
625                 630                 635                 640 


Gln Tyr Leu Asp Lys Cys Leu Lys Lys Cys Lys Gln Gly Lys Ile Gly 
                645                 650                 655     


Ser Gln Asp Phe His Phe Leu His Leu Gly Glu Arg Glu Arg Lys Asn 
            660                 665                 670         


Gly Asn Thr Tyr Tyr Thr Asn Leu Ala Gly Lys Phe Ile Lys Met Pro 
        675                 680                 685             


Leu Asn Phe Pro Arg Gly Leu Phe Met Glu Glu Leu Ile Asn Tyr Phe 
    690                 695                 700                 


Glu Ser Ser Gly Asp Leu His Met Gln Asn Ile Ile Lys Asn Thr Pro 
705                 710                 715                 720 


Arg Leu Ser Thr Thr Phe Leu Leu Lys Glu Tyr Ile Asn Asn Val Leu 
                725                 730                 735     


Ser Asp Asp Thr Pro Asp Phe Tyr Asn Trp Lys Arg Ser Tyr Thr Val 
            740                 745                 750         


Phe Asn Arg Tyr Tyr Asp Lys Arg Lys Gln Asn Ser Arg Asp Ala Ile 
        755                 760                 765             


Thr Lys Ile Tyr Phe Asp Thr Ser Gln Leu Ser Glu Glu Ala Asn Lys 
    770                 775                 780                 


Ile Lys Ala Ala Ile Lys Lys Ile Glu Lys Ser Asp Ile Lys Gly Ala 
785                 790                 795                 800 


Glu Ser Ile Lys Arg Asn Tyr Lys Phe Tyr Gly Asp Asn Glu Lys Gln 
                805                 810                 815     


Leu Arg Gln Ala Lys Ala Cys Asp Thr Ile Leu Phe Leu Ala Ile Arg 
            820                 825                 830         


Asp Leu Phe Pro Thr Ile Glu Ser Ser Val Phe Lys Gly Leu Ala Ile 
        835                 840                 845             


Glu Gln Phe Arg Leu Ser Asp Ile Leu Pro Asp Ala Glu Lys Gly Ile 
    850                 855                 860                 


Leu Ser Gln Ser Ile Glu Ile Arg Leu Pro Leu Tyr Asn Lys Phe Ile 
865                 870                 875                 880 


Ile Gln Lys Gly Leu Lys Leu Lys Asn Tyr Gly Asp Phe Arg Arg Phe 
                885                 890                 895     


Leu Lys Asp Arg Arg Leu Glu Ser Leu Met Pro Tyr Phe Glu Glu Asp 
            900                 905                 910         


Asp Ile Asp Arg Ser Ser Leu Glu Lys Glu Leu Glu Asp Tyr Asp Thr 
        915                 920                 925             


Ala Arg Ile Glu Ile His Arg Val Val Leu Asp Phe Glu Ser His Val 
    930                 935                 940                 


Ile Thr Met Tyr Gln Leu Asn Tyr Leu Asn Pro Glu Asp Pro Cys Ile 
945                 950                 955                 960 


Asn His Glu Thr Ile Leu Asn Cys Phe Phe Gln Asn Asp Pro Ser Asp 
                965                 970                 975     


Ile Arg Lys Gln Leu Met Glu Asn Ile Arg Asn Arg Phe Ser His Asn 
            980                 985                 990         


Glu Tyr Pro Asp Phe Glu Lys Phe  Lys Glu Ile Ile Gln  Glu Asn His 
        995                 1000                 1005             


Gln Gln  Lys Thr Ile Ala Gly  Lys Phe Val Thr Leu  Ala Asn Gln 
    1010                 1015                 1020             


Tyr Phe  Ser Val Glu Glu 
    1025                 


<210>  2516
<211>  1124
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2516

Met Lys Ile Pro Gln Ile Ile Glu Asn Asn Lys His Leu Phe Gly Ala 
1               5                   10                  15      


Tyr Ser Thr Met Ala Leu Ser Asn Ile Arg Asn Ile Leu Asp His Ile 
            20                  25                  30          


Ala Thr Leu Ala Asp Ile Glu Asn Asp Phe Tyr Ser Asp Ser Asp Ser 
        35                  40                  45              


Tyr Trp Tyr His Pro Cys Ile Lys Ile Ile Asp Pro Arg Asn Asn Cys 
    50                  55                  60                  


Thr Asp Ala Ala Lys Ala Asp Phe Val Ile Glu Lys Ile Lys Ser His 
65                  70                  75                  80  


Phe Pro Phe Val Pro Ile Val Ala Glu Ala Gln Arg Gln Ser Asp Ile 
                85                  90                  95      


Leu Arg Ala Lys Lys Gln Leu Asp Ile Ala Val Arg Asn Arg Asp Tyr 
            100                 105                 110         


Gln Lys Gln Glu Glu Leu Lys His Arg Gln Lys Ser Leu Leu Ser Val 
        115                 120                 125             


Thr Asn Ala Asp Ile Tyr Arg Val Leu Asn Asn Met Leu Trp Val Leu 
    130                 135                 140                 


Ala Asn Tyr Arg Asn Gln Thr Val His Tyr Leu Ile Ser Asp Ile Lys 
145                 150                 155                 160 


Phe Glu Asp Gly Ser Asp Phe Leu Asn Tyr Asn Glu Gln Pro Leu Ser 
                165                 170                 175     


Arg Met Leu Asn Asn Tyr Phe Thr Ile Ala Leu Arg Asp Thr Ala Asn 
            180                 185                 190         


Lys Tyr Ser Tyr Ser Pro Glu Ala Leu Ser Phe Ile Gln Ser Ser Arg 
        195                 200                 205             


Tyr Lys Thr Glu Asn Arg Arg Lys Ile Leu Asp Thr Asn Phe Phe Leu 
    210                 215                 220                 


Ser Ile Gln His Asn Asn Ser Asp Thr Asn Pro Lys Asn Leu His Leu 
225                 230                 235                 240 


Ser Gly Val Gly Val Ala Leu Leu Ile Cys Leu Phe Leu Glu Lys Lys 
                245                 250                 255     


Tyr Val Asn Val Phe Leu Gln Lys Leu Pro Ile Tyr Gly Pro Tyr Lys 
            260                 265                 270         


Lys Gln Ser Met Glu Ala Asn Ile Ile Arg Gln Ser Phe Ser Ile His 
        275                 280                 285             


Thr Val Lys Leu Pro Lys Glu Arg Ile Val Ser Glu Lys Ser Asp Phe 
    290                 295                 300                 


Thr Ile Ala Leu Asp Met Leu Asn Glu Leu Lys Arg Cys Pro Lys Gln 
305                 310                 315                 320 


Leu Phe Ser Thr Leu Ser Tyr Ala Asp Gln Asn Ala Phe Arg Ile Val 
                325                 330                 335     


Ser Ser Asp Met Ser Asp Val Leu Gln Val Arg His Thr Asp Arg Phe 
            340                 345                 350         


Ala Gln Leu Ser Leu Glu Tyr Ile Asp Arg Arg Glu Leu Phe Ser Asp 
        355                 360                 365             


Ile Arg Phe His Leu Asn Met Gly Lys Leu Arg Tyr Leu Lys Thr Ala 
    370                 375                 380                 


Asp Lys His Cys Ile Asp Gly Val Ser Arg Val Arg Val Leu Glu Gly 
385                 390                 395                 400 


Lys Ile Asn Ala Phe Gly Arg Ile His Glu Phe Glu Ala Arg Arg Lys 
                405                 410                 415     


Glu Gln Gly Phe Val Glu Trp His Glu Gln Thr Asp Arg Leu Ile Lys 
            420                 425                 430         


Thr Asn Lys Asn Ile Glu Ile Arg Asp Phe Glu His Val Lys Arg Asp 
        435                 440                 445             


Asp Ala Thr Pro Asp Ser Tyr Pro Tyr Ile Ile Asp Thr Tyr Thr His 
    450                 455                 460                 


Tyr Leu Leu Glu Asn Asn Lys Ile Glu Met Arg Phe Gly Asp Tyr Leu 
465                 470                 475                 480 


Pro Lys Leu Val Lys Val Asp Asp Gln Lys Trp Thr Val Tyr Asn Glu 
                485                 490                 495     


Met Pro Thr Cys Cys Met Ser Ala Leu Glu Leu Pro Ala Met Met Phe 
            500                 505                 510         


His Met Met Leu Cys Gly Ser Glu Ala Thr Glu His Leu Ile Lys Ala 
        515                 520                 525             


Glu Val Glu Lys Tyr Lys Lys Leu Phe Gly Ala Met Ala Asn Gly Thr 
    530                 535                 540                 


Leu Ser Lys Glu Asn Ile Gly Asn Phe Gly Ile Ala Met Glu Asp Leu 
545                 550                 555                 560 


Pro Lys Lys Val Ile Asp Cys Val Asn Arg Lys Lys Ser Gly Lys Ser 
                565                 570                 575     


Phe Val Lys Gln Ile Lys Lys Glu Ile Ala Glu Met Leu Ala Asp Thr 
            580                 585                 590         


Asn Leu Arg Ile Val Arg Leu Lys Ser Asp Lys Arg Ser Val Ala Ser 
        595                 600                 605             


Thr Gln Asn Lys Met Gly Lys Arg Gly Phe Arg Ser Ile Gln Pro Gly 
    610                 615                 620                 


Lys Leu Ala Asp Trp Leu Ala Ala Asp Ile Val Lys His Gln Pro Ser 
625                 630                 635                 640 


Leu Arg Thr Gly Asp Asp Tyr Gly Thr Asp Arg Ile Thr Gly Met Asn 
                645                 650                 655     


Tyr Arg Val Met Gln Ser Thr Ile Ala Thr Phe Asn Ala Ala Thr Pro 
            660                 665                 670         


Glu His Ser Leu Asp Glu Leu Lys Arg Val Phe Ser Ala Ala Gln Leu 
        675                 680                 685             


Ile Gln Cys Gln Glu Arg Glu His Pro Phe Leu Gln Lys Ala Leu Asn 
    690                 695                 700                 


Arg Asn Pro Gln Asn Thr Ile Asp Phe Tyr Glu Phe Tyr Leu Gln Ala 
705                 710                 715                 720 


Lys Arg Ala Tyr Tyr Gln Ser Leu Arg Gln Ser Ile Glu Asn Gly Glu 
                725                 730                 735     


Asp Val Lys Leu Pro Tyr Leu Asn Pro Asp Arg Asn Lys Trp Val Arg 
            740                 745                 750         


Arg Gly Ala Ser Phe Tyr Ser Thr Met Gly Asp Ile Tyr Leu Glu Asp 
        755                 760                 765             


Met Pro Ile Glu Leu Pro Arg Gln Met Phe Asp Lys Glu Ile Lys Lys 
    770                 775                 780                 


Ala Leu Ala Gln Leu Pro Ser Met Lys Gly Val Asp Met Lys Gln Ser 
785                 790                 795                 800 


Asn Val Thr Phe Leu Ile Ala Glu Tyr Leu Lys Arg Glu Leu Lys Asp 
                805                 810                 815     


Asp Phe Gln Pro Phe Tyr Lys Trp Asn Arg Asn Tyr Arg Phe Thr Asp 
            820                 825                 830         


Met Met Ile Cys Glu Glu Asn Cys Asp Thr Lys Ala Leu Ala Ser Lys 
        835                 840                 845             


Phe Ile Pro Leu Glu Leu Arg Glu Glu Ile Trp Glu Lys Arg Gly Glu 
    850                 855                 860                 


Leu Lys Asp Ala Tyr Lys Arg Trp Ala Phe Gly Arg Leu Asn Lys Asn 
865                 870                 875                 880 


Pro Asp Ile Lys Arg Leu Ser Pro Ala Glu Lys Asp Glu Leu Leu Glu 
                885                 890                 895     


Lys Arg Ile Ala Lys Cys Arg Asn Glu Tyr Gln Lys Ser Glu Lys Ile 
            900                 905                 910         


Ile Arg Arg Tyr Lys Val Gln Asp Val Leu Met Phe Met Met Val Lys 
        915                 920                 925             


Ser Met Phe Ala Gln Gly Val Phe Thr Ala Glu Ser Lys Glu Phe Ala 
    930                 935                 940                 


Leu Ser Thr Ile Thr Pro Asp Ala Glu Arg Gly Ile Leu Ser Glu Val 
945                 950                 955                 960 


Val Pro Ile Asp Phe Lys Phe Ser Ile Asp Gly Lys Thr Tyr Thr Ile 
                965                 970                 975     


His Ser Asn Gly Met Lys Ile Lys Asn Tyr Gly Asp Phe Tyr Lys Leu 
            980                 985                 990         


Ile Asn Asp Lys Arg Met Lys Ser  Leu Leu Asn Ile Val  Thr His Ser 
        995                 1000                 1005             


Thr Ile  Glu Lys Asp Leu Leu  Glu Lys Glu Phe Ser  Thr Tyr Asp 
    1010                 1015                 1020             


Asp Lys  Arg Pro Glu Ala Val  Glu Ile Ile Phe Glu  Phe Glu Lys 
    1025                 1030                 1035             


Ala Ala  Tyr Glu Lys His Pro  Glu Leu Lys Glu Leu  Leu Thr Pro 
    1040                 1045                 1050             


Glu Arg  Lys Phe Asp Phe Arg  Ala Leu Leu Glu Glu  Leu Gln Ala 
    1055                 1060                 1065             


Lys Ser  Asp Leu Ser Gln Ile  Asp Ala Arg Tyr Leu  Ser Gln Ile 
    1070                 1075                 1080             


Arg Asn  Ala Phe Asn His Asn  Ala Tyr Pro Arg Asn  Leu Lys Ile 
    1085                 1090                 1095             


Thr Ser  Asn Ile Pro Glu Ile  Ala Gln Glu Met Val  Asn Ile Phe 
    1100                 1105                 1110             


Arg Ile  Thr Asp Pro Tyr Lys  Lys Gly Lys Lys 
    1115                 1120                 


<210>  2517
<211>  1107
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2517

Met Ser Thr Arg Tyr Thr Asn Gln Lys Lys Val Glu Glu Asn Ile Asn 
1               5                   10                  15      


Tyr Val Phe Ser Asn Lys Gly Ile Phe Ala Ala Val Ala Glu Lys Thr 
            20                  25                  30          


Leu Thr Asn Tyr Lys Ser Lys Phe Asn Glu Gly Gln Thr Ile Gln Pro 
        35                  40                  45              


Asn Leu His Tyr Phe Ala Val Gly His Thr Phe Lys Asn Ile Asp Thr 
    50                  55                  60                  


Lys Arg Ile Phe Asp Tyr Gln Leu Ser Glu Asp Glu Met Asp Ile Leu 
65                  70                  75                  80  


Pro Thr Lys Tyr Phe Ser Leu Gln Gln Asn Lys Phe Ser Phe Pro Ile 
                85                  90                  95      


Asp Gly Gln Thr Lys Thr Asp Lys Leu Tyr Leu Leu Leu Asp Asn Ile 
            100                 105                 110         


Arg Asn Ile Asn Ala His Phe Ile His Asp Phe Asn Phe Leu Lys Val 
        115                 120                 125             


Asp Asn Ile Asp Glu Asn Ile Ile Cys Phe Leu Ile Asp Ser Phe Glu 
    130                 135                 140                 


Leu Ala Leu Ile Lys Gly Val Phe Ala Lys Lys Tyr Gly Asp Lys Lys 
145                 150                 155                 160 


Ser Lys Leu Arg Leu Asp Phe Leu Ser Asn Glu Ala Arg Asp Glu Ile 
                165                 170                 175     


Leu Thr Asp Ile Leu Glu Asn Leu Asp Lys Glu Leu Ile Val Phe Met 
            180                 185                 190         


Lys Glu Ile Phe Tyr Gln Thr Leu Tyr Val Val Asp Lys Lys Glu Trp 
        195                 200                 205             


Arg Asn Lys Glu Leu Asn Gln Glu Lys Lys Asp Phe Leu Asp Asn His 
    210                 215                 220                 


Leu Ser Ser Lys Glu Asp Trp Ile Asn Trp Ile Leu Phe Asn Cys Val 
225                 230                 235                 240 


Glu Glu Asp Ile Asp Trp Tyr Leu Asn Asn Tyr Gly Asp Tyr Asp Pro 
                245                 250                 255     


His Pro Asp Ser Lys Asn His Lys His Lys Val Leu Thr Ile Glu Lys 
            260                 265                 270         


Gly Lys Tyr Leu Ser Phe Glu Gly Ser Leu Phe Met Met Thr Met Phe 
        275                 280                 285             


Leu Tyr Ala Asn Glu Ala Asn Tyr Leu Ile Pro Lys Leu Lys Gly Tyr 
    290                 295                 300                 


Lys Lys Asn Gly Thr Pro Gln Asp Ala Ser Lys Leu Glu Val Phe Arg 
305                 310                 315                 320 


Phe Phe Ala Lys Lys Phe Lys Ser Gln Asp Val Asp Ser Glu His Lys 
                325                 330                 335     


Gln Tyr Val Lys Phe Arg Asp Met Ile Gln Tyr Val Gly Lys Tyr Pro 
            340                 345                 350         


Thr Val Trp Asn Lys His Ile His Leu Asp Ser Tyr Tyr Val Lys Asp 
        355                 360                 365             


Leu Lys Ala Thr Ile Leu Glu Asn Glu Ile Ile Gln Leu Tyr Gln Glu 
    370                 375                 380                 


Asp Ile Lys Asn His Phe Gln Ser Ile Cys Gly Leu Lys Gln Phe Glu 
385                 390                 395                 400 


Asp Ser Gln Glu Glu Ile Gln Leu Ala Phe Ile Glu Val Ala Lys Asp 
                405                 410                 415     


Tyr Leu Gln Asn Lys Glu Ile Tyr Tyr Thr Gly Glu Tyr Arg Glu Asp 
            420                 425                 430         


Cys Ile Thr Ile Leu Lys Thr Ser Ala Glu His Leu Ala Asn Lys Arg 
        435                 440                 445             


Gln Leu Lys Asp Ile Gln Lys Gln Leu Lys Lys Tyr Ile Asn Lys Ala 
    450                 455                 460                 


Tyr Lys Ser Leu Ser Ser Glu Asp Gln Gly Lys Lys Lys Lys Leu Asp 
465                 470                 475                 480 


Ile Ser Lys Leu Lys Tyr Ile Asp Lys Ile Arg Lys Ser Lys Asn Ser 
                485                 490                 495     


Ile Asn Thr Thr Thr Asp Lys Phe Ala Lys Arg Val Glu Asp Asn Leu 
            500                 505                 510         


Leu Phe Ile Ser Asn Gly Arg Asn Ser Asp Arg Phe Met Val Phe Ala 
        515                 520                 525             


Cys Arg Phe Leu Ala Glu Ile Asn Tyr Phe Gly Lys Asp Ala Gln Phe 
    530                 535                 540                 


Lys Met Tyr Glu Asn Tyr Tyr Ser Glu Glu Glu Gln Asn Ala Leu Lys 
545                 550                 555                 560 


Asp Lys Lys Gln Asn Leu Thr Gln Lys Glu Phe Asp Lys Leu His Tyr 
                565                 570                 575     


His Gly Gly Lys Leu Thr His Phe Glu Thr Phe Glu Asn His Thr Lys 
            580                 585                 590         


Lys Tyr Pro Asn Trp Asp Met Pro Phe Val Val Gln Asn Asn Ala Ile 
        595                 600                 605             


Tyr Val Lys Ile Pro Gly Ile Asn Phe Ile Lys Asn Thr Ala Phe Cys 
    610                 615                 620                 


Ile Gln Arg Asn Val Ile Asn Tyr Leu Leu Glu His Ala Leu Gly Glu 
625                 630                 635                 640 


Asn Tyr Lys Asp Gln Gln Gly Arg Lys Trp Leu Phe Asp Tyr Tyr Glu 
                645                 650                 655     


His Lys Thr Glu Ala Thr Asp Asn Ala Lys Arg Ile Leu Thr Glu Ser 
            660                 665                 670         


Lys Pro Ile Glu Ala Ser Ser Lys Thr Lys Leu Lys Lys Leu Leu Pro 
        675                 680                 685             


Lys Lys Leu Phe Pro Lys Tyr Ser Ala Ser Glu Thr Glu Lys Asn Ile 
    690                 695                 700                 


Leu Arg Lys Tyr Leu Glu Gln Ala Glu Glu Ser Glu Lys Leu Tyr Glu 
705                 710                 715                 720 


Asn Gln Lys Asp Lys Ala Lys Ala Glu Asn Arg Leu Asp Leu Phe Val 
                725                 730                 735     


Asn Lys Asn Lys Gly Lys Gln Phe Lys Leu Arg Phe Ile Phe Lys Ala 
            740                 745                 750         


Trp Gln Leu Met Tyr Phe Lys Lys Gln Tyr Gln Ile Glu Lys Glu Arg 
        755                 760                 765             


Tyr Ala Glu Leu Glu Lys Leu Glu Arg Ile Pro Lys Asn His Glu His 
    770                 775                 780                 


Glu Phe Gly His His Lys Lys Phe Asn Ile Asn Arg Lys Glu Phe Asn 
785                 790                 795                 800 


Leu Phe Ser Lys Trp Leu Phe Ala Met Asp Glu Val Pro Glu Tyr Lys 
                805                 810                 815     


Asn Ser Leu Lys Glu Leu Leu Asp Asp Lys Asn Phe Phe Asp Asn Ser 
            820                 825                 830         


Glu Phe Gln Lys Leu Phe Glu Ser Ser Ser Asn Ile Asn Gln Phe Tyr 
        835                 840                 845             


Glu Ser Thr Lys Ser Lys Phe Lys Asn Trp Leu Asn Asp Gln Gln Val 
    850                 855                 860                 


Arg Asn Val Gly Lys Thr Ile Gln Pro Glu Asn Tyr Tyr Lys Met Met 
865                 870                 875                 880 


Glu Val Gly Asn Phe His Ile Asn Leu Ser His Leu Ile Ala Phe Gly 
                885                 890                 895     


Val Thr His Asn Phe Ile Glu Lys Ser Gly Lys Asn Ile Leu Arg Pro 
            900                 905                 910         


Ile Thr Ser His Ala Lys Tyr Leu Asn Thr Lys Ile Tyr Asp Ile Asp 
        915                 920                 925             


Leu Glu His Ser Asp Ala Ser Asn Leu Glu Lys Asn Ile Phe Arg Lys 
    930                 935                 940                 


Leu Tyr Lys Ile Arg Leu Glu Asp Cys Leu Leu Tyr Glu Ile Ala Leu 
945                 950                 955                 960 


Arg Tyr Phe Gln Pro Asn Leu Asn Leu Arg Gln Lys Ser Tyr Glu Gln 
                965                 970                 975     


Leu Asn Lys Leu Leu Val Gln Lys Ile Ser Ile Thr Ile Lys Ala Asn 
            980                 985                 990         


Asn Ser Gln Thr Tyr Gln Val Leu  Val Pro Phe Arg Asp  Leu Glu Lys 
        995                 1000                 1005             


Phe Glu  Gln Leu Lys Ala Ile  Asp Asp Asn Thr Gln  Asn Asn Phe 
    1010                 1015                 1020             


Ser Leu  Leu Arg Arg Leu Pro  Glu Tyr Leu Ser Gln  Leu Arg Lys 
    1025                 1030                 1035             


Arg Asn  Glu Asn Val Phe Gly  Leu Lys Asp Met Val  Lys Ala Phe 
    1040                 1045                 1050             


Gly Val  Asp Lys Ser Ile Ser  Leu Ala Asp Met Ser  Met Leu Tyr 
    1055                 1060                 1065             


Asn His  Leu Ile Thr Gln Gln  Gly Arg Tyr Thr Asn  Cys Ile Met 
    1070                 1075                 1080             


Ala Leu  Glu Glu Tyr Phe Ile  Trp Lys Glu Glu Cys  Thr Ile Glu 
    1085                 1090                 1095             


Gly Gln  Glu Asp Lys Lys Phe  Arg Leu 
    1100                 1105         


<210>  2518
<211>  944
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2518

Met Lys Ala Asn Asn Gln Ile Val Lys Gly Ile Ser Tyr Asp His Leu 
1               5                   10                  15      


Lys Pro Asp Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Asp Gly Val Ile Gln Glu Phe Thr Met Arg Leu Asn Leu 
        35                  40                  45              


Lys Tyr Asp Pro Glu Asn Lys Asn Gln Ser Leu Phe Ser Tyr Phe Asp 
    50                  55                  60                  


Ile Asn Ala Ser Phe Thr Asp Trp Glu Arg Gly Val Asn Ile Leu Lys 
65                  70                  75                  80  


Glu Tyr Trp Pro Val Met Glu Phe Ile Asp Arg Pro Ala Thr Asp Lys 
                85                  90                  95      


Gln Phe Glu Ser Glu Lys Pro Glu Asn Arg Glu Ala Ala Lys Arg Lys 
            100                 105                 110         


Tyr Phe Ile Ala Thr Leu Arg Ile Leu Leu Lys Ser Ile Lys Glu Leu 
        115                 120                 125             


Arg His Tyr Tyr Thr His Tyr Tyr His Pro Pro Val Gln Leu Ser Glu 
    130                 135                 140                 


Asp Leu Phe Arg Phe Leu Asp His Thr Leu Leu Tyr Thr Ala Phe Asp 
145                 150                 155                 160 


Val Lys Lys Thr Lys Met Lys Asp Asp Lys Thr Arg Gln Leu Leu Asn 
                165                 170                 175     


Gln Asn Leu Ser Leu Glu Leu Glu Lys Leu Lys Lys Leu Lys Val Glu 
            180                 185                 190         


Glu Leu Lys Lys Lys Lys Glu Lys Gly Ile Lys Val Asn Leu Gln Asp 
        195                 200                 205             


Glu Lys Gly Ile Leu Asn Ala Ile Tyr Asn Asp Ala Phe Ala His Ile 
    210                 215                 220                 


Ile Thr Lys Glu Lys Asp Ser Asp Lys Asp Lys Leu Glu Thr Arg Tyr 
225                 230                 235                 240 


Lys Ser Ile Leu Pro Gln Asp Glu Ala Ala Glu Thr Gly Ile Asn Ile 
                245                 250                 255     


Ser Ile Ser Gly Leu Ile Phe Leu Leu Ser Leu Phe Leu Ser Arg Lys 
            260                 265                 270         


Glu Ile Glu Gln Leu Lys Ser Asn Ile Glu Gly Tyr Lys Gly Lys Val 
        275                 280                 285             


Leu Asn Ile Glu Thr Glu Val Asp Arg Lys His Asn Ser Leu Lys Tyr 
    290                 295                 300                 


Met Ala Thr His Trp Val Phe Ser Ile Leu Ala Phe Lys Gly Leu Lys 
305                 310                 315                 320 


Gln Arg Leu Thr Asn Ser Phe Glu Lys Glu Ser Leu Leu Ile Gln Met 
                325                 330                 335     


Met Asp Glu Leu Asn Lys Val Pro Asp Glu Leu Tyr Gln Thr Leu Ser 
            340                 345                 350         


Glu Thr Ala Lys Lys Glu Phe Leu Glu Asp Ile Asn Glu Tyr Val Ser 
        355                 360                 365             


Glu Gly Asp Asp Asn Glu Lys Ala Thr Tyr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Ser Lys Phe Asn Tyr Phe Ala Ile Arg Tyr Leu 
385                 390                 395                 400 


Asp Glu Phe Ala Gln Phe Pro Thr Leu Lys Phe Gln Ile Phe Val Gly 
                405                 410                 415     


Gln Tyr Leu His Asp Asn Arg Pro Lys Thr Leu Ala Ser Asn Gly Met 
            420                 425                 430         


Thr Ala Gln Arg Met Ile Lys Glu Lys Ile Asn Leu Phe Gly Asn Leu 
        435                 440                 445             


Ser Glu Val Thr Lys His Lys Ser Asp Phe Phe Glu Lys Glu Ser Ala 
    450                 455                 460                 


Ala Gln Gly Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Trp Ala Gly 
465                 470                 475                 480 


Asn Asn Ile Pro Val Tyr Ile Asp Met Ile Gly Lys Glu Gly Lys Ala 
                485                 490                 495     


Lys Glu Ile Gln Val Gln Ile Asn Lys Tyr Arg Lys Gln Leu Asn Pro 
            500                 505                 510         


Ala Pro Gln Arg Asp Lys Arg Ile Ser Lys Lys Glu Ile Ile Glu Gln 
        515                 520                 525             


Leu Tyr Lys Glu Lys Val Val Tyr Gly Asp Pro Thr Leu Met Leu Ser 
    530                 535                 540                 


Ala Asn Glu Leu Met Ala Leu Leu Tyr Glu Leu Ile Val Asn Gly Lys 
545                 550                 555                 560 


Ser Gly Ala Glu Leu Glu Asn Lys Ile Val Glu Gln Ile Ile Ala Arg 
                565                 570                 575     


Tyr Glu Gln Ile Glu Ala Tyr Asp Pro Thr Thr Gln Gln Leu Pro Thr 
            580                 585                 590         


Asn Gln Met Pro His Lys Leu Gln Lys Ser Arg Lys Asp Ser Lys Val 
        595                 600                 605             


Thr Asp Thr Asp Lys Leu Leu Lys Thr Ile Asp Lys Glu Ile Asp Glu 
    610                 615                 620                 


Gly Asn Lys Lys Leu Glu Leu Ile Ala Cys His Arg Lys Glu Trp Glu 
625                 630                 635                 640 


Glu Ala Glu Gln Arg Lys Lys Ser Gly Lys Arg Asn Asn Pro Gly Thr 
                645                 650                 655     


Lys Ser Arg Lys His Leu Phe Tyr Ala Ser Glu Met Gly Glu Glu Ala 
            660                 665                 670         


Thr Trp Ile Ala Asn Asp Leu Lys Arg Phe Met Pro Lys Pro Ala Arg 
        675                 680                 685             


Ala Glu Trp Lys Gly Thr His His Ser Glu Leu Gln Arg Leu Leu Ala 
    690                 695                 700                 


Phe Tyr Ser Thr Gln Arg Leu Glu Ala Trp Gln Leu Val Glu Ser Val 
705                 710                 715                 720 


Trp Thr Ala Asn Thr His Ser Phe Trp Glu Glu Asn Phe Lys Glu Ala 
                725                 730                 735     


Phe Tyr Lys Pro Glu Phe Glu Asn Phe Tyr Gly Ala Tyr Ile Lys Ile 
            740                 745                 750         


Arg Thr Lys Ile Leu Thr Thr Cys Arg Asn Phe Val Glu Asn Asn Pro 
        755                 760                 765             


Glu Val Thr Ile Asn Lys His Thr Arg Lys Glu Trp Asp Lys Val Phe 
    770                 775                 780                 


Thr Leu Phe Asp Lys Arg Leu Phe Arg Ile Asn Thr Thr Asp Glu Gln 
785                 790                 795                 800 


Lys Lys Gln Leu Leu Ala Lys Pro Phe Ala Phe Pro Arg Gly Leu Phe 
                805                 810                 815     


Asp Asp Lys Pro Thr Phe Leu Pro Gly Ser Lys Pro Asn Glu Asn Pro 
            820                 825                 830         


Glu Arg Phe Ala Ala Trp Tyr Ser Tyr Gly Tyr Ile Tyr Ser Gly Lys 
        835                 840                 845             


Phe Gln Ser Phe Tyr Asp Met Pro Arg Asp Tyr Ser Asp Trp Tyr Lys 
    850                 855                 860                 


Lys Leu Lys Glu Asp Gly Lys Leu Pro Pro Leu Asp Lys Lys Thr Glu 
865                 870                 875                 880 


Gln Glu Lys Ile Leu Arg Phe Arg Met Asp Cys Asp Leu Asn Ile Lys 
                885                 890                 895     


Tyr Ile Arg Phe Gln Asp Ile Tyr Val Lys Leu Met Val Asp Ser Leu 
            900                 905                 910         


Tyr Lys Ala Val Phe Gly Gln Gln Pro Glu Phe Asp Leu Ser His Leu 
        915                 920                 925             


Tyr Asp Thr Arg Tyr Glu Arg Tyr Glu Asn Asn Thr Ile Ala Gln Arg 
    930                 935                 940                 


<210>  2519
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2519

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Leu Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2520
<211>  1153
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2520

Met Glu Gln Glu Tyr Asp Phe Phe Asn Lys Thr Asp Lys His Phe Phe 
1               5                   10                  15      


Ala Gly Leu Phe Asn Thr Ala Leu Asn Asn Phe Asp Leu Ser Leu Ala 
            20                  25                  30          


Glu Leu Asn Lys Arg Met Asn Tyr Lys Glu Ile Lys Gly Asn Glu Lys 
        35                  40                  45              


Glu Ile Ile Ile Ile Glu Tyr Ala Phe Asn Lys Asp Glu Arg Thr Gln 
    50                  55                  60                  


Leu Asp Phe Glu Asn Asn Phe Lys Tyr Leu Ser Glu Ser Leu Ile Phe 
65                  70                  75                  80  


Leu Asn Arg Ile Pro Ser Phe Ile Ala His Lys Asn Lys Asn Gly Ser 
                85                  90                  95      


Thr Ile Ile Leu Lys Asp Phe Leu Lys Asp Phe Leu Cys Gly Leu Tyr 
            100                 105                 110         


Gln Thr Leu Leu Asn Tyr Arg Asn Tyr Tyr Thr His Phe Glu His Asp 
        115                 120                 125             


Asp Val Ala Ile Gly His Pro Leu Ile Ala Glu Phe Leu Glu Tyr Leu 
    130                 135                 140                 


Leu Phe Asn Ser Val Ser Arg Val Lys Asp Asp Arg Val Lys Thr Lys 
145                 150                 155                 160 


Ala Val Lys Asp Lys Leu Leu Ser Lys Tyr Lys Asp Asp Tyr Thr Thr 
                165                 170                 175     


Ile Ile Glu Tyr Lys Asn Lys Trp Ile Cys Asp Lys Asn Glu Glu Leu 
            180                 185                 190         


Ile Asn Glu Gly Arg Lys Thr Phe Lys Lys Ile Asn Asn Asn Ser Glu 
        195                 200                 205             


Ala Gly Tyr Asn Tyr Val Leu Asn Ser Ile Phe Arg Arg Phe Ile Asp 
    210                 215                 220                 


Asp Ser Thr Asn Thr Pro Lys Leu Gln Leu Asp Glu Lys Cys Ser Thr 
225                 230                 235                 240 


Asp Asp Gly Leu Thr Lys Val Gly Phe Ile Gln Phe Leu Ala Leu Leu 
                245                 250                 255     


Leu Asn Lys Arg Gln Val Ser Leu Leu Phe Asp Asn Ile Thr Tyr Thr 
            260                 265                 270         


Arg Tyr Thr Asp Thr Gln Leu Gln Arg Val Ile Thr Arg Trp Ile Phe 
        275                 280                 285             


Thr Tyr Glu Ser Tyr Arg Asp Ile Asn Tyr Leu Phe Lys Ser Glu Tyr 
    290                 295                 300                 


Asp Glu His Ala Leu Leu Leu Gln Met Val Ser Glu Leu Thr Lys Cys 
305                 310                 315                 320 


Pro Lys Asn Leu Tyr Pro Tyr Leu Ser Glu Lys Asn Lys Asp Asn Phe 
                325                 330                 335     


Leu Glu Asp Ile Asn Ile Tyr Phe Lys Glu Asn Ala Lys Leu Phe Glu 
            340                 345                 350         


Asp Asp Ala Leu Val Ser His Glu Val Val Arg Lys Arg Phe Glu Asp 
        355                 360                 365             


Lys Phe Pro Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe Ala Lys Phe 
    370                 375                 380                 


Pro Ser Leu Arg Phe Gln Val Asn Met Gly Lys Phe Asn His Asp Ser 
385                 390                 395                 400 


Arg Glu Lys Glu Phe Ile Ser Thr Gly Lys Lys Thr Glu Arg Leu Ile 
                405                 410                 415     


Leu Glu Asn Leu Thr Val Phe Glu Asn Leu Ser Glu Ala Thr Lys Lys 
            420                 425                 430         


Lys Asn Leu Tyr Phe Glu Lys Ser Asp Ser Lys Glu Lys Ser Asp Lys 
        435                 440                 445             


Glu Ser Asn Tyr Lys Asp Val Ser Asp Ser Ile Glu Val Ser Asp Trp 
    450                 455                 460                 


Val Glu Tyr Pro Arg Pro Lys Tyr Gln Phe Asn Lys Asn Thr Ile Gly 
465                 470                 475                 480 


Ile Trp Leu Asp Cys Asp Gly Leu Gly Asn Tyr Asp Glu Ser Pro Lys 
                485                 490                 495     


Arg Glu Asn Lys Lys Pro Thr Lys His Asp Ile Leu Asp Lys Ile Glu 
            500                 505                 510         


Leu Lys Asp Ser Phe Lys Lys Pro Ile Ala Tyr Leu Ser Leu His Glu 
        515                 520                 525             


Leu Pro Ala Leu Leu Tyr Cys Leu Leu Ile Glu Lys Lys Asp Gly Arg 
    530                 535                 540                 


Phe Ile Glu Asn Arg Ile Lys Gly Lys Ile Arg Lys Gln Arg Ser Phe 
545                 550                 555                 560 


Leu Glu Ser Leu Lys Gly Asp Tyr Gln Tyr Ser Glu Glu Glu Leu Lys 
                565                 570                 575     


Gln Phe Pro Lys Lys Ile Arg Leu Ile Leu Thr Lys Lys Ser Asn Ile 
            580                 585                 590         


Asn Ser Glu Lys Ile Lys Arg Gln Ile Ser Asn Glu Ile Lys Val Asn 
        595                 600                 605             


Pro Leu Lys Glu Ile Arg Glu Lys Tyr Thr Pro Lys Ser Glu Thr Glu 
    610                 615                 620                 


Leu Ser Leu Ser Glu Lys Gly Lys Ile Ala Thr Trp Leu Ser Lys Asp 
625                 630                 635                 640 


Ile Lys Arg Phe Val Ala Lys Asp Val Lys Gly Pro Ser Glu Glu Asp 
                645                 650                 655     


Lys Asn Lys Ser Trp Lys Gly Tyr Gln Phe Ser Glu Phe Gln Ala Leu 
            660                 665                 670         


Leu Ser Tyr Tyr Asp Ile Asp Lys Ser Lys Leu Ser Asp Phe Val Phe 
        675                 680                 685             


Lys Asp Leu Asn Phe Asn Ile Asn Lys Asp Phe Pro Phe Gln Gly Ile 
    690                 695                 700                 


Val Phe Asn Lys Ser Ser Leu Phe Asp Phe Tyr Thr His Tyr Leu Lys 
705                 710                 715                 720 


Ser Arg Arg Glu Tyr Leu Asn His Leu Leu Glu Asn Phe Ser Asn Thr 
                725                 730                 735     


Thr Asn Glu Glu Leu Leu Leu Pro Phe Lys Ala Ser Lys Phe Lys Ile 
            740                 745                 750         


Lys Glu Leu Glu Glu Tyr Arg Lys Asn Lys Leu Glu Glu Pro Val Met 
        755                 760                 765             


Leu Val Arg Gly Val Phe Asp Asp Lys Pro Thr Ala Ser Arg Glu Lys 
    770                 775                 780                 


Asp Lys Thr Glu Phe Ala Lys Trp Phe Thr Val Ser Met Asn Ser Ser 
785                 790                 795                 800 


Ser Ala Gln Lys Phe Tyr Asp Phe Asp Lys Ile Tyr Pro Leu Thr Leu 
                805                 810                 815     


Ser Val Ile Asn Gly Arg Lys Ser Glu Glu Asn Leu Thr Ile Asn Thr 
            820                 825                 830         


Lys Ala Gly Leu Thr Lys Gln Tyr Ile Pro Phe Gln Ser Ile Arg Asn 
        835                 840                 845             


Lys Asp Ser Phe Val Leu Thr Asp Phe Glu Lys Glu Glu Ile Lys Lys 
    850                 855                 860                 


Asn Ile Lys Asn Pro Asn Glu Asn Leu Asn Lys Asn Phe Tyr Lys Tyr 
865                 870                 875                 880 


Lys Gln Lys Gln Ile Tyr Lys Asn Glu Ala Thr Ile Arg Lys Thr Met 
                885                 890                 895     


Arg Asn Asp Tyr Tyr Met Leu Gln Met Ile Lys Thr Phe Phe Ile Asp 
            900                 905                 910         


Thr Asn Glu Phe Ile Asn Ser Thr Phe Glu Asn Ile Ser Leu Lys Asp 
        915                 920                 925             


Phe Tyr Leu Thr Lys Ala Glu Lys Glu Lys Ile Gln Lys Asn Ala Ile 
    930                 935                 940                 


Ser Gln Ser Glu Lys Glu Lys Gly Asp Lys Thr Asn Val Ile Phe Asn 
945                 950                 955                 960 


Glu Ser Tyr Ile Leu Asp Lys Arg Val Glu Leu Ser Leu Leu Glu Gly 
                965                 970                 975     


Lys Ile Ile Gly Asn Val Ala Leu Lys Asp Arg Gly Lys Tyr Lys Lys 
            980                 985                 990         


Leu Ser Gln Asp Gln Lys Val Lys  Gln Leu Thr Glu Tyr  Phe Asp Lys 
        995                 1000                 1005             


Thr Trp  Ser Phe Glu Glu Ile  Ile Asn Glu Ile Ser  Asp Tyr Glu 
    1010                 1015                 1020             


His Ile  Arg Ser Lys Val Phe  Phe Asn Ser Val His  Glu Leu Glu 
    1025                 1030                 1035             


Glu Lys  Ile Tyr Leu Lys Ala  Lys Thr Glu Asn Lys  Val Glu Glu 
    1040                 1045                 1050             


Leu Lys  Asp Lys Gly His His  Asn Phe Arg Asn Tyr  Leu Lys Tyr 
    1055                 1060                 1065             


Tyr Phe  Ile Asn Asp Glu His  Gln Lys Glu Glu Phe  Asn Lys Ile 
    1070                 1075                 1080             


Lys Arg  Thr Asn Ser Ile Leu  Glu Val Lys Glu Glu  Phe Lys Gln 
    1085                 1090                 1095             


Leu Ile  Leu Leu Ile Glu Ile  Arg Asn Lys Phe Ala  His Asn Gln 
    1100                 1105                 1110             


Leu Ile  Pro Lys Thr Ser Phe  Asp Tyr Leu Thr Ser  Lys Phe Ser 
    1115                 1120                 1125             


Met Glu  Thr Asn Glu Arg Val  Ala Ser Tyr Leu Asn  Arg Ile Phe 
    1130                 1135                 1140             


Asn Thr  Ile Lys Thr Glu Ile  Leu Ile Arg 
    1145                 1150             


<210>  2521
<211>  1090
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2521

Met Lys Glu Glu Glu Thr Pro Val Val Ser Thr Tyr Asn Lys Asp Asn 
1               5                   10                  15      


Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val Tyr 
            20                  25                  30          


Ile Thr Ile Asn His Ile Asn Lys Ile Leu Gly Glu Ala Glu Ile Asn 
        35                  40                  45              


Ile Asp Gly Tyr Asp Ile Pro Leu Lys Asn Ile Trp Ser Gly Ile Arg 
    50                  55                  60                  


Asp Ile Asn Lys Lys Ala Arg Leu Glu Glu Leu Met Ile Lys His Phe 
65                  70                  75                  80  


Pro Phe Leu Glu Ala Met Thr His Gln Gln His Leu Thr Gly Asn Thr 
                85                  90                  95      


Lys Gln Lys Glu Glu Lys Gln Ala Glu Ile Gln Ser Phe Glu Ile Leu 
            100                 105                 110         


Lys Asp Asn Leu Phe Leu Leu Leu Lys Met Leu Gln Asp Leu Arg Asn 
        115                 120                 125             


His Tyr Ser His Tyr Lys His Ser Lys Ser Leu Glu Arg Pro Lys Phe 
    130                 135                 140                 


Asp Glu Asp Ile Arg Asn Lys Leu Tyr Asn Ile Leu Asp Thr Ser Ile 
145                 150                 155                 160 


Arg Leu Val Lys Glu Asp Tyr Lys His Asn Pro Asp Ile Lys Pro Lys 
                165                 170                 175     


Glu His Phe Lys His Leu Asp Arg Lys Arg Asn Glu Lys Phe Arg Tyr 
            180                 185                 190         


Ser Phe Ala Asp Asn Glu Gly Asn Ile Thr Ile Ser Gly Leu Leu Phe 
        195                 200                 205             


Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Val Gln Lys 
    210                 215                 220                 


Lys Leu Glu Gly Phe Arg Cys Ser Asn Glu Ser Tyr Gln Lys Met Thr 
225                 230                 235                 240 


Asn Glu Val Phe Cys Arg Asn Arg Ile Leu Leu Pro Lys Leu Arg Leu 
                245                 250                 255     


Glu Ser Thr Gln Thr Lys Asp Trp Ile Leu Leu Asp Met Leu Asn Glu 
            260                 265                 270         


Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Lys Gly Glu Asp 
        275                 280                 285             


Arg Lys Lys Phe Glu Val Pro Phe Asp Ser Thr Asp Glu Asp Tyr Asp 
    290                 295                 300                 


Ala Glu Gln Asp Pro Phe Lys Asn Thr Leu Ile Arg His Gln Asp Arg 
305                 310                 315                 320 


Phe Pro Tyr Phe Val Leu Arg Tyr Ser Asp Tyr Asn Glu Ile Phe Glu 
                325                 330                 335     


Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile Tyr 
            340                 345                 350         


Lys Lys Leu Ile Gly Gly Glu Lys Glu Asp Arg His Leu Thr His Lys 
        355                 360                 365             


Leu Tyr Gly Phe Glu Arg Leu Gln Glu Phe Ala Lys Gln Asn Arg Pro 
    370                 375                 380                 


Asp Glu Trp Lys Ala Ile Ile Lys Asp Leu Asp Thr Phe Lys Lys Gln 
385                 390                 395                 400 


Glu Asp Glu Lys Val Asn Glu Lys Pro Tyr Ile Ser Glu Thr Thr Pro 
                405                 410                 415     


His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Ala Phe Lys Asn His 
            420                 425                 430         


Asn Ile Trp Pro Ser Thr Asn Thr Glu Leu Thr Asn Asn Lys Arg Lys 
        435                 440                 445             


Lys Tyr Asn Leu Arg Thr Ser Ile Lys Ala Glu Ala Phe Leu Ser Val 
    450                 455                 460                 


His Glu Leu Leu Pro Met Met Phe Tyr Tyr Met Leu Leu Lys Thr Lys 
465                 470                 475                 480 


Asn Glu Ser Pro Arg Lys Val Glu Ala Ile Ile Glu Ser Lys Ile Lys 
                485                 490                 495     


Asp Ile Phe Thr Leu Tyr Asp Ala Phe Ala Asn Asp Glu Ile Asp Asn 
            500                 505                 510         


Thr Asp Glu Leu Glu Lys Tyr Cys Glu Asp Lys Asp Ile Lys Ile Gly 
        515                 520                 525             


His Leu Pro Lys Gln Met Ile Ala Ile Leu Tyr Asn Lys His Lys Asp 
    530                 535                 540                 


Met Val Glu Lys Ala Lys Val Lys Gln Glu Lys Met Lys Leu Ala Thr 
545                 550                 555                 560 


Glu Asn Arg Leu Lys Thr Leu Asp Lys Leu Ile Glu Gly Lys Met Lys 
                565                 570                 575     


Tyr Ala Lys Arg Gly Ile Ser Pro Leu Lys Ser Gly Glu Ile Ala Ser 
            580                 585                 590         


Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln Arg Asp Glu 
        595                 600                 605             


Asn Gly Glu Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln 
    610                 615                 620                 


Leu Leu Gln Arg Thr Leu Ala Leu Phe Gly Ser Glu His Glu Arg Leu 
625                 630                 635                 640 


Thr Pro Tyr Phe Lys Gln Met Asn Leu Ile Gly Asp Thr Asn Ser His 
                645                 650                 655     


Pro Phe Leu Lys Gln Thr Glu Trp Glu Lys Cys Asn Asn Ile Leu Ser 
            660                 665                 670         


Phe Tyr Arg Asn Tyr Leu Lys Ala Lys Ile Glu Phe Leu Asn Lys Leu 
        675                 680                 685             


Lys Pro Glu Asp Trp Lys Lys Asn Gln Cys Phe Leu Lys Leu Lys Glu 
    690                 695                 700                 


Pro Lys Thr Asn Arg Asp Thr Leu Val Gln Gly Trp Lys Asn Gly Phe 
705                 710                 715                 720 


Asn Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg Lys Trp Phe Ile 
                725                 730                 735     


Lys Tyr Trp Lys Lys Ile Lys Val Asp Asp Leu Lys Arg Val Gly Leu 
            740                 745                 750         


Val Ala Lys Val Ile Pro Leu Phe Phe Ser Glu Lys Tyr Lys Asp Ser 
        755                 760                 765             


Val Gln Pro Phe Tyr Asn Tyr Pro Phe Asn Val Gly Asn Ile Asp Lys 
    770                 775                 780                 


Pro Lys Glu Lys Asp Phe Leu Asp Ile Ala Arg Arg Arg Lys Leu Trp 
785                 790                 795                 800 


Asp Lys Lys Gln Leu Glu Phe Lys Gly Lys Thr Glu Glu Glu Lys Arg 
                805                 810                 815     


Lys Asn Pro Ser Tyr Leu Asp Phe Lys Ser Trp Lys Lys Phe Glu Arg 
            820                 825                 830         


Glu Ile Arg Leu Thr Arg Asn Gln Asp Ile Val Thr Trp Leu Met Cys 
        835                 840                 845             


Ile Glu Ile Tyr Asn Asn Gln Lys Val Glu Asn Leu Asn Thr Gly His 
    850                 855                 860                 


Ile Tyr Leu Lys Asp Ile Ile Thr Asn Val Glu Glu Glu Arg Ser Asn 
865                 870                 875                 880 


Asn Ile Leu Asn Gln Ile Lys Ser Met Gln Leu Pro Val Thr Val Tyr 
                885                 890                 895     


Glu Asn Glu Ser Ser Pro Lys Lys Lys Tyr Leu Arg Thr Ile Tyr Ile 
            900                 905                 910         


Glu Glu Asn Gly Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu 
        915                 920                 925             


Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Val Lys Thr Asn 
    930                 935                 940                 


Ser Glu Ala Glu Ser Lys Arg Asn Pro Ile Ser Lys Leu Arg Val Glu 
945                 950                 955                 960 


His Glu Leu Arg Glu Tyr Gln Lys Ala Arg Ile Glu Ile Ile Lys Asp 
                965                 970                 975     


Met Leu Ala Leu Glu Lys Thr Leu Ile Asp Asn Tyr Asp Ser Leu Asp 
            980                 985                 990         


Thr Asp Asn Phe His Asn Met Leu  Thr Gly Trp Leu Glu  Leu Lys Gly 
        995                 1000                 1005             


Glu Val  Asn Lys Ala Lys Phe  Asn Asn Asp Val Lys  Leu Leu Thr 
    1010                 1015                 1020             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1025                 1030                 1035             


Glu Asn  Leu Phe Val Asn Ile  Glu Arg Phe Ser Leu  Ser Ser Ser 
    1040                 1045                 1050             


Lys Ile  Leu Glu Ser Lys Gly  Leu Ser Ile Ala Val  Lys Leu Lys 
    1055                 1060                 1065             


Glu Glu  Val Ser Lys Ile Ile  Lys Lys Ile Gln Glu  Glu Glu Asp 
    1070                 1075                 1080             


Gly Lys  Lys Glu Lys Glu Thr  
    1085                 1090 


<210>  2522
<211>  1098
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2522

Met Asn Asn Glu Gln Asn Leu Glu Gln Arg Ile Phe Ala Gln Ala Lys 
1               5                   10                  15      


Asn Ile Arg Asp Asp Lys Ala Tyr Phe Gly Ala His Leu Asn Leu Ala 
            20                  25                  30          


Arg His Asn Ala Phe Ile Ile Leu His His Ile Asn Gln Arg Leu Gly 
        35                  40                  45              


Phe Ile Asp Gln Asn Val Gln Asp Asp Ala Gln Phe Lys Lys Phe Lys 
    50                  55                  60                  


Cys Leu Thr Ile Leu Lys Gln Ser Ser Lys Pro Asp Leu Ile Ala Lys 
65                  70                  75                  80  


Ser Leu Asp Leu Ile Arg Phe His Phe Pro Phe Leu Gln Ile Leu Thr 
                85                  90                  95      


Asp Lys Leu Ser Asp Ile Arg Ser Ser Asn Gly Glu Arg Lys Ile Leu 
            100                 105                 110         


Thr Pro Gln Glu Glu Gly Glu Ile Ile Glu Ser Leu Leu Thr Asp Leu 
        115                 120                 125             


Asn Gly Tyr Arg Asn Glu Tyr Cys His Gly Glu Asn Lys Ser His Val 
    130                 135                 140                 


Pro Asp Ser Tyr Leu Ile Lys Asn Leu Lys Ser Ile Tyr Asp Ala Ser 
145                 150                 155                 160 


Leu Arg Met Val Lys Glu Arg Phe Lys Leu Glu Pro His Lys Ile Lys 
                165                 170                 175     


His Leu Glu Arg Asn Asn Lys Asp Gly Glu Lys Leu Asn Phe Lys Tyr 
            180                 185                 190         


Ala Leu Ser Asn Asn Ser Ser Ile Ser Glu Lys Gly Leu Val Phe Phe 
        195                 200                 205             


Ile Asn Leu Phe Leu Glu Val Lys Asp Ser Tyr Ser Phe Ile Lys Lys 
    210                 215                 220                 


Ile Glu Gly Phe Lys Asn Ala Gly Thr Asn Ser Leu Asn Ala Thr Thr 
225                 230                 235                 240 


Tyr Cys Phe Thr Ile Gln His Val Arg Leu Pro Asn Pro Lys Ile Thr 
                245                 250                 255     


Ser Gln Glu Tyr Thr Lys Glu Glu Leu Leu Leu Arg Met Met Asn Tyr 
            260                 265                 270         


Leu Glu Lys Val Pro Asp Gln Ile Phe Lys Thr Leu Ser Pro Ala Asp 
        275                 280                 285             


Gln Glu Asn Cys Lys Ser Asn Val Asp Val Phe Glu Thr Pro Ile Glu 
    290                 295                 300                 


Gly Asp Leu Ile Glu Lys Ser Leu His Lys Arg Tyr Arg Asp Gln Phe 
305                 310                 315                 320 


Pro Glu Phe Ala Leu Asn Tyr Ile Asp Tyr Tyr Lys Leu Phe Pro Asn 
                325                 330                 335     


Ile Arg Phe Gln Ile Asn Leu Gly Lys Phe Ile Phe Ser Val Lys Asp 
            340                 345                 350         


Lys Glu Ile Leu Gly Glu Thr Arg Lys Arg Arg Gln Ile Gln Met Leu 
        355                 360                 365             


Arg Gly Phe Gly Gln Ile Gln Asp Tyr Gln Asn Lys Lys Asn Ile Pro 
    370                 375                 380                 


Glu Ile Trp Gln Ser Leu Ile Asn Lys Ser His Glu Ile Pro Glu Asp 
385                 390                 395                 400 


Phe Pro Asp Pro Tyr Ile Asn Asp Met Glu Pro His Tyr His Ile Glu 
                405                 410                 415     


Asn Asn Asn Ile Tyr Phe Lys Phe Met Glu Pro Asp Thr Thr His Trp 
            420                 425                 430         


Pro Arg Ile Asp Ala Arg Ile Glu Asn Gln Asn Asn Ile Asn Ala His 
        435                 440                 445             


Pro Arg Pro Arg Leu Leu Gln Ala Asp Gly Ile Leu Ser Val Tyr Glu 
    450                 455                 460                 


Leu Ala Pro Leu Leu Phe Tyr Glu Met Ile Arg Ser Asp Lys Ser Lys 
465                 470                 475                 480 


Ser Ala Glu Thr Ile Leu Ser Ile Gln Lys Ser Asn Ile Glu Arg Leu 
                485                 490                 495     


Leu Asn Asp Ile Lys Ser Gly Glu Leu Thr Lys Val Ala Leu Asp Lys 
            500                 505                 510         


Ile Pro Asn Pro Tyr Ser Pro Ser Thr Lys Lys Phe Asn Thr Ala Lys 
        515                 520                 525             


Gln Val Ile Leu Lys Glu Lys Ile Glu Lys Arg Lys Ile Glu Leu Asn 
    530                 535                 540                 


Glu Lys Leu Lys Lys Tyr Lys Leu Ala Leu Asp Asp Leu Pro Lys Met 
545                 550                 555                 560 


Ile Leu Tyr Tyr Leu Leu Asn Ile Glu His Glu Asp Ile Ser Leu Lys 
                565                 570                 575     


Val Ile Pro Ile Ile Lys Ser Met Gln Val Glu Thr Asn His Leu Leu 
            580                 585                 590         


Asn Lys Leu Gln His Asn Leu Glu Lys Arg Asn Lys Pro Gly Glu Lys 
        595                 600                 605             


Gly Ser Lys Leu Ile Leu Ser Gly Glu Leu Ala Ser Phe Leu Ala Gln 
    610                 615                 620                 


Asp Met Leu Ala Leu Gln Ala Lys Ser Asp Asn Ser Arg Asp Lys Ala 
625                 630                 635                 640 


Asn Ser Gln Glu Tyr Gln His Leu Gln Tyr Lys Leu Ala Tyr Tyr Ser 
                645                 650                 655     


Leu Tyr Ile Asp Glu Phe Lys Ser Ile Phe Lys Lys Leu Asn Leu Ile 
            660                 665                 670         


Asp Ser Asp Lys Phe Ser His Pro Phe Leu Ser Lys Leu Thr Lys Ile 
        675                 680                 685             


Phe Pro Asn Ile Ile Gln Phe Tyr Glu Trp Tyr Leu Asn Glu Arg Lys 
    690                 695                 700                 


Lys Trp Leu Met Asp Ile Glu Thr Lys Pro Glu Glu Ala Leu Lys Phe 
705                 710                 715                 720 


Ile Lys Leu Lys Lys Ser Val Asn Ile Thr Gly Glu Gln Leu Val Asp 
                725                 730                 735     


Gln Phe Leu Val Lys Thr Asn Gly Asn Gln Ala Gly Ile Pro Tyr Asn 
            740                 745                 750         


Phe Pro Arg Gly Ile Phe Asp Asp Ala Ile Lys Ser Glu Leu Glu Lys 
        755                 760                 765             


Asn Asp Lys Met Lys Ala Ile Ile Ser Asn Thr Lys Arg Val Asn Ser 
    770                 775                 780                 


His Phe Leu Ile Asn Arg Tyr Ile Glu His Glu Lys Asn Asn Lys Ser 
785                 790                 795                 800 


Gln Ser Phe Tyr Glu Trp Lys Arg Asn Tyr Glu Ile Tyr Asp Arg Leu 
                805                 810                 815     


Glu Asp Asp Arg Lys Lys Met Phe Asp Pro Leu Pro Lys Lys Tyr Lys 
            820                 825                 830         


Thr Asn Asp Glu Leu Gly His Gly Leu Lys Lys His Arg Glu Tyr Ile 
        835                 840                 845             


Lys Thr Leu Ala Glu Arg Asp Val Ile Lys Arg Gly Asn Ser Asn Leu 
    850                 855                 860                 


Ser Lys Glu Lys Leu Thr Thr Leu Phe Lys Asn Tyr Glu Glu Asn Glu 
865                 870                 875                 880 


Lys Glu Ile Arg Leu Gln Lys Thr Gln Asp Gln Val Leu Tyr Leu Met 
                885                 890                 895     


Ile Val Lys Ser Ile Ser Asp Asn Phe Ser Pro Gly Glu Phe Asn Asn 
            900                 905                 910         


Ile Ala Leu Gln Asp Phe Val Pro Asn Ala Ile Asn Ser Pro Leu Ala 
        915                 920                 925             


Lys Arg Ile Pro Phe Glu Ile Lys Tyr Gly Glu Lys Lys Ile Phe Gln 
    930                 935                 940                 


Glu Glu Ile Gln Ile Lys Lys Ile Gly Glu Phe His Arg Phe Leu Lys 
945                 950                 955                 960 


Asp Arg Arg Leu Ile Asn Leu Met Ala Tyr Ile Lys Lys Glu Arg Ile 
                965                 970                 975     


Ser Arg Ser Glu Leu Glu Tyr Glu Leu Gly Glu Tyr Gln Lys Gln Arg 
            980                 985                 990         


Ile Leu Phe Leu Glu Lys Val Leu  Glu Phe Glu Gln Lys  Leu Tyr Ala 
        995                 1000                 1005             


Tyr Asp  Lys Phe Tyr Phe Asp  Asn Ile Ile Ala Glu  Asn Asn Arg 
    1010                 1015                 1020             


Val Glu  His Trp Gln Tyr Leu  Arg Tyr Phe Glu Glu  Lys Phe Val 
    1025                 1030                 1035             


Leu Thr  Pro Glu Gln Lys Glu  Gln Ser Ser Asn Leu  Arg Asn Lys 
    1040                 1045                 1050             


Phe Ser  His Asn Glu Tyr Pro  Glu Ile Met Tyr Phe  Glu Asp Val 
    1055                 1060                 1065             


Cys Ser  Gly Glu Glu Lys Ile  Gly Val Ala Ser Gln  Leu Ala Gln 
    1070                 1075                 1080             


Ile Gly  Ile Lys Leu Tyr Glu  Asp Met Val Ser Gln  Ile Gln Lys 
    1085                 1090                 1095             


<210>  2523
<211>  1128
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2523

Met Glu Asn Lys Arg Thr Leu Lys Asp His Pro Gln Tyr Phe Gly Ala 
1               5                   10                  15      


Phe Leu Asn Met Ala Arg His Asn Val Phe Val Ile Asn Asn His Leu 
            20                  25                  30          


Ala Glu Arg Phe Lys Leu Ser Pro Leu Pro Glu Asp Ser His Ile Pro 
        35                  40                  45              


Thr Ser Phe Leu Thr Arg Pro Ile Lys Glu Arg Pro Asn His Ile Phe 
    50                  55                  60                  


Ser His Leu Ile Arg Phe Ile Pro Ile Ala Lys Val Phe Asp Pro Glu 
65                  70                  75                  80  


Gln Leu Pro Lys Glu Glu Arg Thr Glu Glu Lys Ser Lys Thr Gly Lys 
                85                  90                  95      


Asp Phe Asn Lys Leu Lys Glu Thr Phe Lys Ile Cys Phe Ser Glu Leu 
            100                 105                 110         


Asn Asp Phe Arg Asn Asp Tyr Ser His Phe Phe Ser Thr Lys Lys Arg 
        115                 120                 125             


Thr Glu Arg Lys Leu Met Val Asp Lys Leu Leu Ala Asp Phe Leu Thr 
    130                 135                 140                 


Thr Asn Tyr Ser Arg Ala Ile Gln Tyr Ser Ile Lys Arg Phe Thr Gly 
145                 150                 155                 160 


Val Phe Lys Asp Glu His Phe Glu Leu Ala Arg Lys Asn Ile Ile Leu 
                165                 170                 175     


Val Asp Asn Glu Asn Lys Ile Thr Glu Asp Gly Leu Val Phe Phe Thr 
            180                 185                 190         


Cys Leu Phe Leu Asp Arg Glu Asn Ala Phe Gln Phe Ile Asn Lys Ile 
        195                 200                 205             


Ile Gly Phe Lys Gly Thr His Thr Leu Glu Phe Lys Ala Thr Arg Glu 
    210                 215                 220                 


Val Phe Cys Ala Phe Cys Val Asn Leu Pro His Asp Arg Phe Ile Ser 
225                 230                 235                 240 


Asp Asp Pro Glu Gln Ala Phe Ile Leu Asp Met Leu Asn Glu Leu Asn 
                245                 250                 255     


Arg Cys Pro Ser Glu Leu Phe Asn Ser Leu Thr Glu Glu Gly Lys Lys 
            260                 265                 270         


Pro Phe Gln Pro Thr Leu Asp Ser Lys Gln Ile Thr Asn Ile Glu Asp 
        275                 280                 285             


Asn Asn Ala Val Ala Lys Glu Leu Pro Asp Glu Asp Phe Tyr Glu Tyr 
    290                 295                 300                 


Met Gln Ser Ile Thr Lys Arg Ile Arg His Glu Asp Arg Phe Pro Tyr 
305                 310                 315                 320 


Leu Ala Leu Lys Tyr Leu Asp Thr Thr Lys Ala Phe Asn Lys Ile Arg 
                325                 330                 335     


Phe Gln Ile Asp Leu Gly Lys Phe Gln Ile Asp Glu Tyr Lys Lys Gln 
            340                 345                 350         


Phe Asn Asn Ala Glu Glu Asp Arg Met Ile Ile Glu Asn Ala Lys Ala 
        355                 360                 365             


Phe Gly Arg Leu Asp Glu Phe Thr Ser Ile Glu Lys Thr Lys Asp Glu 
    370                 375                 380                 


Leu Glu Lys Val Ile Gly Lys Met Ile Asn Lys Asp Gly Phe Lys Asn 
385                 390                 395                 400 


Val Asp Ser Lys Gln Phe Ala Phe Glu Gln Phe Ser Pro Arg Tyr Asn 
                405                 410                 415     


Tyr Asp Lys Glu Lys Asn Lys Ile Gly Phe Gln Phe Phe Pro Asn Gly 
            420                 425                 430         


Ile Gly Val Pro Ile Tyr Pro Lys Leu Lys Lys Ser Glu Asn Glu Lys 
        435                 440                 445             


Ser Asn Val Lys Tyr Asn Leu Phe Gln Asn Asn Pro His Ala Phe Leu 
    450                 455                 460                 


Ser Ile His Glu Leu Pro Lys Val Val Leu Leu Glu Leu Leu Glu Lys 
465                 470                 475                 480 


Gly Lys Val Glu Thr Ile Ile Glu Glu Phe Ile Asn Ser Asn Asn Thr 
                485                 490                 495     


Lys Ile Leu Asn Lys Asp Phe Ile Glu Glu Ile Lys Asn Lys Leu Lys 
            500                 505                 510         


Phe Glu Lys Pro Phe Tyr Lys Lys Phe Gln Lys Lys Asn Leu His Ala 
        515                 520                 525             


Tyr Asp Asn Pro Ser Ile Glu Asp Tyr Thr Glu Arg Lys Asn Lys Leu 
    530                 535                 540                 


Asn Glu Ile Leu Asn Asp Leu Lys Thr Arg Lys Glu Gln Leu Asn Glu 
545                 550                 555                 560 


Leu Leu Ser His Tyr Asn Leu Asn His Thr Gln Ile Pro Thr Arg Ile 
                565                 570                 575     


Val Asn Tyr Trp Leu Asp Ile Lys Glu Val Gly Lys Glu Thr Ala Ile 
            580                 585                 590         


Ala Asn Arg Ile Lys Ala Phe Arg Ser Glu Cys Ala Glu Arg Leu Lys 
        595                 600                 605             


Asp Asn Lys Lys Gly Lys Ala Pro Lys Ile Gly Val Met Ala Thr Phe 
    610                 615                 620                 


Leu Ala Lys Asp Ile Val Asn Met Val Ile Asp Glu Asn Ile Lys Lys 
625                 630                 635                 640 


Lys Ile Thr Pro Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu 
                645                 650                 655     


Phe Ala Gly Asp Glu Asn Lys Gln Leu Phe Ile Thr Ile Cys Asn Glu 
            660                 665                 670         


Leu Asn Leu Phe Asn Lys Glu Thr Gly His Pro Phe Leu Lys Asp Ile 
        675                 680                 685             


Arg Ile Asn Glu Ile His Tyr Thr Ser Asp Phe Tyr Gln Met Tyr Leu 
    690                 695                 700                 


Glu Lys Lys Gln Asn Trp Ile Val Asn Val Phe Tyr Lys Leu Glu Trp 
705                 710                 715                 720 


Asn Glu Lys Ala Lys Lys Lys Leu Thr Thr Val Ala Leu Pro Glu Asn 
                725                 730                 735     


Leu Thr Leu Pro Phe Ser Ile Arg Asn Leu Asp Arg Thr Lys Ser Asp 
            740                 745                 750         


Phe Asp Ser Trp Leu Asn Asn Leu Ile Asn Gly Lys Lys Glu Lys Asp 
        755                 760                 765             


Asn Pro Lys Pro Leu Asp Leu Pro Thr Asp Leu Phe Asp Asn Ala Leu 
    770                 775                 780                 


Val Glu Val Leu Thr Asn Lys Ile Gly Ile Glu Arg Asn Pro Lys His 
785                 790                 795                 800 


Asn Tyr Ser Tyr Leu Leu Thr Gln Trp Leu Lys Asp Thr Gln Pro Phe 
                805                 810                 815     


Tyr Asn Phe Glu Arg Glu Tyr Glu Ile Tyr Lys Asp Lys Val Tyr Lys 
            820                 825                 830         


Glu Thr Val Lys Phe Lys Leu Gly Ser Lys Pro Thr Phe Lys Asp Tyr 
        835                 840                 845             


Phe Leu Ser Ser Ile Lys Thr Val Leu Gln Lys Leu Asn Ile Glu Arg 
    850                 855                 860                 


Lys Ile Glu Arg Lys Pro Leu Leu Asn Glu Asn Asp Val Leu Arg Val 
865                 870                 875                 880 


Phe Asn His Ala Ile Thr Glu Asn Glu Lys Leu Ile Arg Phe Tyr Gln 
                885                 890                 895     


Thr Lys Asp Arg Val Met Leu Leu Met Leu Lys Glu Leu Met Lys Ser 
            900                 905                 910         


Asp Arg Asp Leu Asn Ile Thr Leu His Asn Ile Glu Ala Ala Leu Asn 
        915                 920                 925             


Glu Thr Val Glu Ile Glu Gln Lys Val Lys Gly Phe Leu Ser Tyr Asp 
    930                 935                 940                 


Ala Glu Gly Asn Tyr Ile Asp Lys Gln Asn Asp Arg Thr Glu Glu Ile 
945                 950                 955                 960 


Asn Lys Thr Ile Thr Asp Lys Arg Lys Arg Lys Asp Phe Ser Val Phe 
                965                 970                 975     


Lys Lys Phe Ile Ser Asp Arg Arg Leu Pro Glu Leu Phe Gln Tyr Phe 
            980                 985                 990         


Lys Glu Asn Glu Ile Pro Tyr Gln  Gln Leu Lys Asp Glu  Leu Asp Glu 
        995                 1000                 1005             


Tyr Asn  Lys Glu Lys Glu Lys  Val Phe Asp Glu Thr  Phe Lys Leu 
    1010                 1015                 1020             


Glu Thr  Ala Ile Ile Glu Lys  Ala Glu Asn Glu Ile  Lys Glu Leu 
    1025                 1030                 1035             


Phe Arg  Asp Lys Lys Gly Asn  Lys Ile Glu Gly Asn  Ile Gln Phe 
    1040                 1045                 1050             


Glu Pro  Tyr Leu Lys Trp Leu  Lys Glu Lys Asn Phe  Ile Gly Asp 
    1055                 1060                 1065             


Thr Glu  Phe Lys Ile Leu Lys  Val Ile Arg Asn Ala  Phe Ser His 
    1070                 1075                 1080             


Asn Gln  Phe Pro Pro Lys Ile  Val Met Asp Lys Asn  Ile Gln Trp 
    1085                 1090                 1095             


Gln Gln  Asn Ile Ser Ile Ser  Gln Gln Ile Tyr Glu  Thr Tyr Ala 
    1100                 1105                 1110             


Ser Thr  Ile Ala Thr Val Leu  Asp Lys Ile Ala Thr  Leu Ile Leu 
    1115                 1120                 1125             


<210>  2524
<211>  1121
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2524

Met Glu Asp Asp Lys Lys Thr Thr Glu Ser Ile Ser Tyr Glu Leu Glu 
1               5                   10                  15      


Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val 
            20                  25                  30          


Tyr Ile Thr Ile Asn His Ile Asn Lys Leu Leu Glu Ile Arg Glu Ile 
        35                  40                  45              


Asp Asn Asp Glu Lys Val Leu Asp Ile Lys Ala Leu Trp Gln Lys Gly 
    50                  55                  60                  


Asn Lys Asp Leu Asn Gln Lys Ala Arg Leu Arg Glu Leu Met Thr Lys 
65                  70                  75                  80  


His Phe Pro Phe Leu Glu Thr Ala Ile Tyr Thr Lys Asn Lys Glu Asp 
                85                  90                  95      


Lys Glu Glu Val Lys Gln Glu Lys Gln Ala Glu Ala Gln Ser Leu Glu 
            100                 105                 110         


Ser Leu Lys Asp Cys Leu Phe Leu Phe Leu Glu Lys Leu Gln Glu Ala 
        115                 120                 125             


Arg Asn Tyr Tyr Ser His Tyr Lys Tyr Ser Glu Phe Ser Lys Glu Pro 
    130                 135                 140                 


Glu Phe Lys Glu Glu Leu Leu Glu Lys Met Tyr Asn Ile Phe Asp Ala 
145                 150                 155                 160 


Asn Ile Gln Leu Val Ile Asn Asp Tyr Gln His Asn Lys Asp Ile Asp 
                165                 170                 175     


Pro Glu Glu Asp Phe Lys His Leu Asp Thr Ile Glu Asp Ser Ser Tyr 
            180                 185                 190         


Ser Phe Thr Val Lys Asp Asn Lys Glu Lys Ile Thr Ala Ser Gly Leu 
        195                 200                 205             


Leu Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Met 
    210                 215                 220                 


Gln Gln Lys Leu Arg Gly Phe Lys Asp Asn Arg Glu Ser Lys Lys Lys 
225                 230                 235                 240 


Met Thr His Glu Val Phe Cys Arg Ser Arg Met Leu Leu Pro Lys Leu 
                245                 250                 255     


Arg Leu Lys Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu 
            260                 265                 270         


Asn Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Gln Gly 
        275                 280                 285             


Lys Tyr Arg Glu Lys Phe Lys Val Pro Phe Asp Pro Ala Asp Glu Asp 
    290                 295                 300                 


Tyr Asp Ala Glu Gln Glu Pro Phe Lys Asn Thr Leu Val Arg His Gln 
305                 310                 315                 320 


Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Tyr Asn Glu Ile 
                325                 330                 335     


Phe Thr Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser 
            340                 345                 350         


Ile Tyr Lys Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg His Leu Thr 
        355                 360                 365             


His Lys Leu Tyr Gly Phe Glu Arg Ile Gln Glu Phe Asp Lys Gln Asn 
    370                 375                 380                 


Arg Pro Asp Glu Trp Lys Ala Leu Val Lys Asp Leu Asp Thr Tyr Glu 
385                 390                 395                 400 


Thr Ser Asn Glu Arg Tyr Ile Ser Glu Thr Thr Pro His Tyr His Leu 
                405                 410                 415     


Glu Asn Gln Lys Ile Gly Ile Arg Asn Lys Lys Lys Lys Lys Lys Lys 
            420                 425                 430         


Asn Ile Trp Pro Ser Leu Glu Ile Asn Thr Thr Val Asn Glu Arg Ser 
        435                 440                 445             


Lys Tyr Asn Leu Gly Lys Ser Phe Lys Ala Glu Ala Phe Leu Ser Val 
    450                 455                 460                 


His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Thr Lys Glu 
465                 470                 475                 480 


Glu Pro Asn Asn Lys Glu Ile Asn Ala Ser Lys Val Glu Gly Ile Ile 
                485                 490                 495     


Glu Lys Lys Ile Arg Asp Met Tyr Lys Leu Tyr Asp Ala Phe Ala Asn 
            500                 505                 510         


Gly Glu Ile Asn Ser Lys Glu Glu Leu Lys Glu Tyr Leu Lys Gly Lys 
        515                 520                 525             


Asp Ile Glu Ile Val His Leu Pro Lys Gln Met Ile Ala Ile Leu Glu 
    530                 535                 540                 


Ser Lys Pro Lys Asp Met Val Glu Glu Ala Lys Arg Lys Gln Lys Glu 
545                 550                 555                 560 


Met Val Lys Asp Thr Lys Lys Leu Leu Ala Thr Leu Glu Lys Gln Thr 
                565                 570                 575     


Gln Gly Glu Ile Glu Asp Gly Gly Arg Asn Ile Arg Leu Leu Lys Ser 
            580                 585                 590         


Gly Glu Ile Ala Arg Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro 
        595                 600                 605             


Val Gln Lys Asp Asn Glu Gly Asn Pro Leu Asn Asn Ser Lys Ala Asn 
    610                 615                 620                 


Ser Thr Glu Tyr Gln Met Leu Gln Arg Ser Leu Ala Leu Tyr Asn Lys 
625                 630                 635                 640 


Glu Glu Lys Pro Thr Arg Tyr Phe Arg Gln Val Asn Leu Ile Asn Ser 
                645                 650                 655     


Ser Asn Pro His Pro Phe Leu Lys Trp Thr Lys Trp Glu Glu Cys Asn 
            660                 665                 670         


Asn Ile Leu Ser Phe Tyr Arg Asn Tyr Leu Thr Lys Lys Ile Glu Phe 
        675                 680                 685             


Leu Asn Lys Leu Lys Pro Glu Asp Trp Glu Lys Asn Gln Tyr Phe Leu 
    690                 695                 700                 


Lys Leu Lys Glu Pro Lys Thr Asn Arg Glu Thr Leu Val Gln Gly Trp 
705                 710                 715                 720 


Lys Asn Gly Phe Asn Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg 
                725                 730                 735     


Glu Trp Phe Lys Arg His Gln Asn Asp Ser Lys Glu Tyr Glu Lys Val 
            740                 745                 750         


Glu Ala Leu Lys Arg Val Gly Leu Val Thr Lys Val Ile Pro Leu Phe 
        755                 760                 765             


Phe Lys Glu Glu Tyr Phe Lys Glu Asp Ala Gln Lys Glu Ile Asn Asn 
    770                 775                 780                 


Cys Val Gln Pro Phe Tyr Gly Phe Pro Tyr Asn Val Gly Asn Ile His 
785                 790                 795                 800 


Lys Pro Lys Glu Glu Asp Phe Leu His Arg Glu Glu Arg Ile Glu Leu 
                805                 810                 815     


Trp Asp Lys Lys Lys Asp Lys Phe Lys Gly Tyr Lys Ala Lys Lys Lys 
            820                 825                 830         


Phe Lys Glu Met Thr Asp Lys Glu Lys Glu Glu His Arg Ser Tyr Leu 
        835                 840                 845             


Glu Phe Lys Ser Trp Asn Gln Phe Glu Arg Glu Leu Arg Leu Val Arg 
    850                 855                 860                 


Asn Gln Asp Ile Val Thr Trp Leu Leu Cys Met Glu Leu Ile Asp Lys 
865                 870                 875                 880 


Leu Lys Val Glu Gly Leu Asn Val Glu Glu Leu Gln Lys Leu Arg Leu 
                885                 890                 895     


Lys Asp Ile Asp Thr Asp Thr Ala Lys Gln Glu Lys Asn Asn Ile Leu 
            900                 905                 910         


Asn Arg Val Met Pro Met Gln Leu Pro Val Thr Val Tyr Glu Ile Asp 
        915                 920                 925             


Asp Ser His Asn Ile Val Lys Asp Arg Pro Leu His Thr Val Tyr Ile 
    930                 935                 940                 


Glu Glu Thr Lys Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu 
945                 950                 955                 960 


Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Val Asp Thr Ser 
                965                 970                 975     


Ser Glu Ala Glu Leu Lys Ser Asn Pro Ile Ser Lys Ser Val Val Glu 
            980                 985                 990         


Tyr Glu Leu Gly Glu Tyr Gln Asn  Ala Arg Ile Glu Thr  Ile Lys Asp 
        995                 1000                 1005             


Met Leu  Leu Leu Glu Lys Thr  Leu Ile Lys Lys Asp  Lys Asn Leu 
    1010                 1015                 1020             


Pro Thr  Asp Asn Phe Ser Asp  Met Leu Asn Gly Trp  Leu Glu Gly 
    1025                 1030                 1035             


Lys Asp  Lys Ala Asp Lys Thr  Arg Phe Gln Asn Asp  Val Asp Leu 
    1040                 1045                 1050             


Leu Val  Ala Val Arg Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met 
    1055                 1060                 1065             


Arg Asn  Arg Ile Ala Phe Ala  Asn Ile Asn Pro Phe  Ser Leu Ser 
    1070                 1075                 1080             


Ser Ala  Asn Thr Ser Glu Glu  Lys Lys Leu Asp Ile  Ala Asn Gln 
    1085                 1090                 1095             


Leu Lys  Asp Lys Thr His Lys  Thr Ile Lys Lys Ile  Ile Glu Ile 
    1100                 1105                 1110             


Glu Lys  Pro Ile Glu Thr Lys  Glu 
    1115                 1120     


<210>  2525
<211>  1196
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2525

Met Lys Thr Ser Lys Glu Phe Glu Asn Tyr Asn Ser Arg Asn Ser Phe 
1               5                   10                  15      


Lys Lys Ile Phe Asp Phe Lys Gly Glu Ile Ala Pro Ile Ala Glu Lys 
            20                  25                  30          


Ala Asn Arg Asn Leu Glu Leu Lys Thr Lys Asn Glu Thr Asn Leu Val 
        35                  40                  45              


Gln Arg Val His Tyr Phe Ala Ile Gly His Thr Phe Lys Tyr Ile Asp 
    50                  55                  60                  


Thr Glu Thr Leu Phe Glu Trp Val Val Asp Glu Glu Thr Gln Met Lys 
65                  70                  75                  80  


Gln Pro Thr Lys Phe Leu Ser Leu Gln Ser Phe Asp Asp Ser Phe Cys 
                85                  90                  95      


Asp Glu Leu Gln Lys Ile Thr Val Val Gly Thr Asn Asn Glu Tyr Asn 
            100                 105                 110         


Gly Leu Ile Pro Ala Ile Arg Asn Ile Asn Ser His Tyr Ile His Ser 
        115                 120                 125             


Phe Glu Lys Ile Arg Ile Asp Ser Leu Ser Pro Val Met Val Lys Phe 
    130                 135                 140                 


Leu Lys Glu Ser Phe Glu Leu Ser Val Ile Gln Ile Tyr Ile Lys Glu 
145                 150                 155                 160 


Glu Asn Glu Leu Lys Arg Ser Lys Asn Glu Arg Leu Ala Ser Thr Lys 
                165                 170                 175     


Glu Ile Ile Glu Gln Asn Gly Phe Gly Lys Arg Leu Val Gln Phe Leu 
            180                 185                 190         


Cys Asp Lys Phe Tyr Pro Val Gly Asn Lys Thr Thr Tyr Pro Glu Asp 
        195                 200                 205             


Tyr Leu Glu Tyr Arg Lys Gln Phe Arg Asn Leu Ser Lys Asp Glu Ala 
    210                 215                 220                 


Ile Asp Ser Leu Leu Phe Val Glu Val Glu Thr Ala Phe Asp Trp Leu 
225                 230                 235                 240 


Leu Phe Glu Thr Tyr Pro Ala Phe Asn Ile Ala Val Gly Lys Tyr Leu 
                245                 250                 255     


Ser Phe Tyr Ser Cys Leu Phe Leu Leu Ser Met Phe Leu Tyr Lys Ser 
            260                 265                 270         


Glu Ala Asn Gln Leu Ile Ser Lys Ile Lys Gln Phe Lys Arg Asn Lys 
        275                 280                 285             


Ile Gln Glu Glu Lys Ser Lys Arg Glu Ile Phe Thr Phe Phe Ser Lys 
    290                 295                 300                 


Arg Phe Ser Ser Gln Asp Ile Asp Ser Glu Glu Asn His Leu Val Lys 
305                 310                 315                 320 


Phe Arg Asp Leu Ile Gln Tyr Leu Asn Arg Tyr Pro Val Ala Trp Asn 
                325                 330                 335     


Lys Asp Ile Glu Leu Glu Ser Gln His Pro Val Met Thr Asp Arg Leu 
            340                 345                 350         


Lys Ala Lys Ile Ile Glu Met Glu Ile Asp Ser Ser Phe Pro Ile Tyr 
        355                 360                 365             


Ala Glu Asn Asn Arg Phe His Val Phe Ala Lys Tyr Gln Ile Trp Gly 
    370                 375                 380                 


Lys Lys Tyr Phe Gly Lys Lys Ile Glu Lys Glu Tyr Ile Glu Gln Ser 
385                 390                 395                 400 


Phe Asn Gly Asn Glu Val Glu Glu Phe Ser Tyr Glu Ile Asn Thr Ser 
                405                 410                 415     


Pro Glu Leu Lys Gly Phe Tyr Leu Lys Leu Ala Asp Leu Lys Ser Lys 
            420                 425                 430         


Pro Gly Leu Tyr Glu Lys His Lys Ala Glu Ile Lys Arg Thr Glu Thr 
        435                 440                 445             


Ser Ile Lys Glu Leu Ile Glu Gln Asn Val Pro Asn Pro Ile Thr Glu 
    450                 455                 460                 


Lys Leu Lys Thr Arg Ile Glu Lys Asn Leu Leu Phe Val Ser Tyr Gly 
465                 470                 475                 480 


Arg Asn Gln Asp Arg Phe Met Asp Phe Ala Thr Arg Tyr Leu Ala Glu 
                485                 490                 495     


Thr Asn Tyr Phe Gly Asn Asp Ala Arg Phe Lys Met Tyr Gln Phe Tyr 
            500                 505                 510         


Thr Thr Thr Glu Gln Asn Lys Glu Tyr Glu Asn Leu Lys Glu Val Lys 
        515                 520                 525             


Ser Lys Lys Glu Ile Asp Arg Leu Lys Phe His His Gly Arg Pro Ile 
    530                 535                 540                 


His Phe Ser Thr Tyr Ser Asn His His Lys Arg Tyr Glu Ser Trp Asp 
545                 550                 555                 560 


Thr Pro Phe Val Phe Glu Asn Asn Ala Ile Gln Val Lys Met Thr Leu 
                565                 570                 575     


Asp His Gly Ile Glu Lys Thr Val Ser Ile Gln Arg Ser Leu Met Val 
            580                 585                 590         


Tyr Leu Leu Glu Asp Ala Leu Phe Lys Ala Asp Lys Ser Met Val Asp 
        595                 600                 605             


Ser Ala Gly Lys His Leu Ile Ser Glu Tyr Phe Thr His Gln Gln Gln 
    610                 615                 620                 


Asp Phe Asn Tyr Ser Arg Leu Val Leu Glu Gln Asn Glu Ser Ile Asn 
625                 630                 635                 640 


Thr Glu Gln Lys Asn Lys Phe Lys Lys Ile Leu Pro Lys Arg Leu Leu 
                645                 650                 655     


Asn His Tyr Leu Pro Ala Ile Gln Asn Asn Thr Pro Ala Phe Ser Thr 
            660                 665                 670         


Leu Gln Leu Ile Leu Glu Lys Ala Lys Leu Ala Glu Glu Arg Tyr Lys 
        675                 680                 685             


Lys Leu Thr Glu Lys Val Lys Thr Glu Gly Asn Tyr Asp Asp Phe Ile 
    690                 695                 700                 


Lys Arg Asn Lys Gly Lys Gln Phe Lys Leu Gln Phe Ile Arg Lys Ala 
705                 710                 715                 720 


Trp His Leu Met Tyr Phe Lys Glu Ser Tyr Lys Gln Gln Ala Ser Phe 
                725                 730                 735     


Ser Gly His His Lys Arg Phe His Ile Glu Arg Asp Glu Phe Asn Asp 
            740                 745                 750         


Phe Ser Arg Phe Met Phe Ala Phe Asp Glu Val Pro Ala Tyr Lys Asp 
        755                 760                 765             


Tyr Leu Lys Gln Leu Leu Asp Lys Lys Gly Phe Phe Glu Asn Gln Gln 
    770                 775                 780                 


Phe Lys Ala Leu Phe Glu Asn Gly Thr Ser Leu Asp Asn Leu Tyr Val 
785                 790                 795                 800 


Lys Thr Lys Gln Ala Tyr Glu Lys Trp Leu Ile Gly Gln Asn Asn Arg 
                805                 810                 815     


Glu Leu Glu Ala Thr Lys Tyr Thr Leu Gln Ser Tyr Glu Gln Phe Phe 
            820                 825                 830         


Ala Asp Asp Met Phe Tyr Ile Asn Gln Ser His Phe Ile Ser Phe Leu 
        835                 840                 845             


Glu Ser Lys Ser Leu Leu Ser Arg Asp Glu Gln Gly Gln Met Arg Phe 
    850                 855                 860                 


Asn Ala Leu Ala Asn Cys Ala Phe Leu Val Ser Glu Phe Tyr Tyr Thr 
865                 870                 875                 880 


Asp Lys Leu Asp Lys Thr Glu Tyr Lys Thr Asn Arg Lys Leu Phe Asn 
                885                 890                 895     


Gln Leu Arg Ser Val Arg Leu Glu Asp Ala Leu Leu Tyr Glu Met Ala 
            900                 905                 910         


Met Cys Tyr Leu Lys Ile Asp Gln Gln Val Val Gln Lys Ala Lys Ala 
        915                 920                 925             


His Val Ile Glu Ile Leu Thr Gln Asn Val Gln Phe Asp Ile Cys Asn 
    930                 935                 940                 


Ser Gln Asp Lys Leu Val Tyr His Leu Val Ile Pro Phe Asn Lys Ile 
945                 950                 955                 960 


Asp Ala Tyr Val Glu Leu Leu Asn Arg Lys Glu Thr Asp Glu Thr Ile 
                965                 970                 975     


Ser Ser Gly Ser Ser Phe Ile Thr Asn Val Asp Lys Tyr Ile Glu Met 
            980                 985                 990         


Ile Trp Asn Glu Ile Pro Trp Lys  Glu Lys Asn Glu Asn  Ala Lys Lys 
        995                 1000                 1005             


Ile Thr  His Ala Ala Met Tyr  Pro Ile Gly Glu Lys  Tyr Ser Arg 
    1010                 1015                 1020             


Gln Lys  Thr Ile Thr Tyr Asp  Asp Leu Gln Lys Ile  Tyr Gln His 
    1025                 1030                 1035             


Leu Leu  Ser Ser Ser Asn Lys  Leu Thr Asn Val Ser  Met Gln Ile 
    1040                 1045                 1050             


Glu Arg  Tyr Tyr Leu Cys Lys  Pro Asp Gly Gln Gly  His Val Val 
    1055                 1060                 1065             


Phe Asn  Gly Glu Thr Asp Arg  Lys Thr Gly Cys Tyr  Leu Ile Arg 
    1070                 1075                 1080             


Phe Glu  Lys Thr Gly Val Pro  Lys Thr Tyr Phe Gly  Val Gly Glu 
    1085                 1090                 1095             


Leu Asn  Ile Arg Asn Lys Ala  Phe His Phe Leu Ile  Thr Pro Ser 
    1100                 1105                 1110             


Lys Ser  Tyr Glu Lys Trp Leu  Met Asp Val Glu Arg  Glu Phe Ile 
    1115                 1120                 1125             


Leu Lys  Glu Val Lys Pro Asn  Asn Pro Lys Ala Tyr  Thr Asp Leu 
    1130                 1135                 1140             


Asn Arg  Ser Val Lys Leu Val  Cys Asp Ile Leu Leu  Asn Thr Leu 
    1145                 1150                 1155             


His Asn  Asn Tyr Phe Lys Leu  Thr Asp Ser Asp Lys  Gly Ile Pro 
    1160                 1165                 1170             


Lys Glu  Glu Gln Gly Lys Gln  Lys Gln Lys Asn Ala  Gln Ile Thr 
    1175                 1180                 1185             


Tyr Phe  Thr Lys His Ile Leu  Tyr 
    1190                 1195     


<210>  2526
<211>  1197
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2526

Met Ser Asn Asn Phe Arg Thr Gln Ser Thr His Arg Pro Pro His Leu 
1               5                   10                  15      


Gln Lys Thr Thr Pro Pro Ser Lys Leu Glu Thr Trp Thr Gly Gly Lys 
            20                  25                  30          


Arg Pro Glu Leu Ala Val Phe Tyr Asn Val Ala Tyr Phe Arg Ile Ala 
        35                  40                  45              


Gly Met Leu Ser His Tyr Leu Asn Lys Thr His Glu His Asp Lys Asp 
    50                  55                  60                  


Ala Leu Glu Leu Leu Phe Lys Lys Val Val Ser Gly Glu Asp Gln Leu 
65                  70                  75                  80  


Ser Asp Ala Val Cys Ser Lys Leu Arg Asp Tyr Leu Trp Lys Ser Tyr 
                85                  90                  95      


Thr Thr Gln Gln Glu Asn Ser Ser Gly Tyr Ala Leu Asn Gln Glu Asp 
            100                 105                 110         


Arg Asp Leu Val Leu Leu Met Leu Arg Lys Leu Gln Asp Val Arg Asn 
        115                 120                 125             


Phe Gln Ser His Val Trp His Asp Asn Arg Ala Leu Val Phe Pro Met 
    130                 135                 140                 


Glu Leu Cys Ala His Ile Glu Arg Met His Glu Ala Ala Ile Met Ala 
145                 150                 155                 160 


Gln Gly Ile Asp Met Ala Ser Ala Val Val Thr Tyr His Asp Asn Tyr 
                165                 170                 175     


Lys Val Tyr Asp Ser Lys Met Arg Phe Asn Gln Gly Arg Lys Asp Leu 
            180                 185                 190         


Gln Ala Phe Phe Asp Arg Trp Asp Thr Asp His Tyr Ile Thr Gln Glu 
        195                 200                 205             


Gly Arg Ile Phe Phe Leu Ser Phe Phe Leu Thr Arg Ser Glu Met Ala 
    210                 215                 220                 


Arg Leu Leu Gln Gln Ser Lys Gly Ser Lys Arg Asn Asp Lys Pro Glu 
225                 230                 235                 240 


Phe Lys Ile Lys His Ala Ile Tyr Arg Tyr Phe Thr His Arg Asp Ala 
                245                 250                 255     


Ala Ser Arg Asn His Tyr Gly Leu His Asp Asn Ile Leu Ser Glu Leu 
            260                 265                 270         


Pro Asn Glu Gln Arg Ala Gln Ile Met Ala Ala Arg Gln Val Tyr Lys 
        275                 280                 285             


Ile Ile Asn Tyr Leu Asn Asp Ile Pro Tyr Arg Ser His Asp Pro Ala 
    290                 295                 300                 


Leu Phe Pro Leu Phe Leu Ala Asp Gly Thr Glu Ala Ile Asp Glu His 
305                 310                 315                 320 


Gly Leu Leu Gln Trp Lys Gln Glu Thr Asp Phe Leu Pro Glu Ile Thr 
                325                 330                 335     


Ala Lys Ala Arg Lys Val Pro Ala Leu Ser Glu Thr Glu Arg Phe Gly 
            340                 345                 350         


Val Arg Gly Arg Lys Ala Thr Lys Ala Ile Asp Asp Arg Thr Leu Glu 
        355                 360                 365             


Val Glu Arg Gly Phe Glu Leu Gln Trp Val Gly Asn Asp Arg Tyr Asn 
    370                 375                 380                 


Phe Thr Ile Pro Thr Arg His Phe His Arg Cys Ala Leu Asp Ala Ile 
385                 390                 395                 400 


Arg Asn Gly Asp Lys Gly Ala Thr Phe Ala Asp Arg Leu Lys Val Phe 
                405                 410                 415     


Ile Gly Asp Arg Glu His Leu Leu Asp Arg Leu His Lys Glu Phe Thr 
            420                 425                 430         


Ile Leu Pro Leu Arg Gln Ala Asp Phe Thr Leu Glu Lys Glu Leu Asp 
        435                 440                 445             


Glu Tyr Tyr Lys Phe Arg Leu Arg Gly Asp Gly Lys Leu Thr Lys Ser 
    450                 455                 460                 


Leu Gly Gln Trp Leu Asp Ala Ile Asp Arg Gln Asn Val Arg Lys Tyr 
465                 470                 475                 480 


Pro Glu Ala Leu Ala Lys Leu Lys Glu Gln Leu Arg Asn Ser Pro Ile 
                485                 490                 495     


Ile Leu Thr Tyr His Gly Leu Ser Phe Thr Asn Glu Arg Lys Pro Arg 
            500                 505                 510         


Ala Ala Asp Arg Phe Thr Glu Phe Ala Val Lys Tyr Leu Ile Asp His 
        515                 520                 525             


Arg Val Val Pro Asp Trp Leu Trp Gly Ile Glu His Phe Glu Pro Val 
    530                 535                 540                 


Thr Glu Glu Lys Leu Asp Arg Arg Ser Gly Ala Thr Met Lys Arg Glu 
545                 550                 555                 560 


Val Leu Lys Arg Lys Ile Thr Tyr His Asp His Val Pro Glu Lys Asp 
                565                 570                 575     


Glu Lys Asp Ile Gly Ile Leu Asn Pro Glu Leu Ser Ser Glu Pro Arg 
            580                 585                 590         


Leu Ala Ile Ser Asp Ser His Ala Leu Val Lys His Arg Gln Asp Asp 
        595                 600                 605             


Gly Ile Leu Phe Arg Ile Gly His Arg Ala Leu Lys Asn Ile Leu Ile 
    610                 615                 620                 


Ala His Gln Gln Gly Lys Pro Val Arg Asn Leu Leu Pro Arg Leu Ile 
625                 630                 635                 640 


Glu Asp Leu Gln Leu Val Asn Gly Ala Arg Arg Asn Gly Thr Thr Leu 
                645                 650                 655     


Asn Leu Ser Thr Leu Lys Leu Phe Asp Lys Asn Ser Leu Ala Glu Ala 
            660                 665                 670         


Thr Arg Asn Ala Ile Ala Pro Ile Ala Ala Glu Ser Ile Gln Arg Thr 
        675                 680                 685             


Ala Ala Leu Ala Lys Ala Leu His Gly Asn Thr Asp Arg Met Gly Gln 
    690                 695                 700                 


Arg Thr Pro Gly Arg Ile Ala Ser Leu Ile Thr Glu Leu Glu Arg Phe 
705                 710                 715                 720 


Gly Val Pro Asp Ser Glu Met Pro Arg Met Ser Arg Asp Ser Lys Asn 
                725                 730                 735     


Arg Gln Ile Met Arg Cys Tyr Lys Tyr Phe Asp Trp Lys Tyr Leu Asn 
            740                 745                 750         


Asp Ala Gln Tyr Lys Phe Leu Arg Gln His Glu Tyr Gln Asn Met Ser 
        755                 760                 765             


Ile Tyr His Tyr Met Leu Trp Asp Ile Arg Lys Asp Arg Gly Leu Ala 
    770                 775                 780                 


His Gly Lys Tyr Gly Asp Leu Leu Lys Gly Ile Thr Pro His Met Pro 
785                 790                 795                 800 


Pro Thr Val Gln Gln Leu Leu Phe Lys Ser Arg Asp Leu Asn Asp Leu 
                805                 810                 815     


Leu Arg Asn Thr Ala Thr Ala Thr Ile Val Leu Leu Asn Ser Trp Lys 
            820                 825                 830         


Glu Glu Leu Leu Lys Pro Ser Ile Asp Asp Glu Arg Leu Asn Ala Ile 
        835                 840                 845             


Met Ser Arg Leu Gly Val Pro Val Ser Glu Ala Asn Arg Val Phe Asn 
    850                 855                 860                 


Gln His Leu Pro Ile Ala Ile His Pro Met Leu Pro Val Arg Ala Tyr 
865                 870                 875                 880 


Tyr Ser Ala Gln Asp Ile Ser Lys Leu Ser Leu Ser Arg Ser Ile Trp 
                885                 890                 895     


Lys Asn Lys Glu Glu Arg Gln Pro Leu Val Asp Glu His Tyr Ala Tyr 
            900                 905                 910         


Glu Asp Tyr Leu Ala Gln Tyr Ala Phe Val Pro Glu Arg Lys Pro Leu 
        915                 920                 925             


Arg Lys Arg Val Ile Gly Gln Met Asn Glu Leu Ile Thr Glu Asp Ala 
    930                 935                 940                 


Leu Leu Trp Lys Cys Ala Met Thr Tyr Leu Asn Asn Ala Ser Val Val 
945                 950                 955                 960 


Val Arg Asp Val Ile Lys Gln Ala Leu Val Arg Gly Asp Gln Ala Met 
                965                 970                 975     


Lys Val Gly Ser Leu Phe Asp Ala Thr Ile Ser Ile Pro Leu Gln Pro 
            980                 985                 990         


Leu Glu Val Lys Asn Gln Gly Leu  Arg Lys Leu Leu Gln  Glu Glu Phe 
        995                 1000                 1005             


Asp Ser  Leu Lys Ile Ala Ala  Ile Glu Val Asp Leu  Lys Phe Lys 
    1010                 1015                 1020             


Gln Leu  Asp Asp Tyr Leu Phe  Met Glu Ser Arg Pro  Gln Leu Leu 
    1025                 1030                 1035             


Lys Ala  Ala Cys Gln Val Val  Arg Arg Phe Val Ala  Ser Gly Lys 
    1040                 1045                 1050             


Pro Asp  Glu Val Asn Val Val  Glu Glu Asn Gly Arg  Lys Lys Tyr 
    1055                 1060                 1065             


Ser Met  Pro Tyr Gly Val Ile  Tyr Gln Glu Ile Gln  Arg Ile Gln 
    1070                 1075                 1080             


Asn Gln  Ala Val Ser Trp Ala  Gly Thr Leu Leu Ala  Asn Glu Glu 
    1085                 1090                 1095             


Arg Val  Val Arg Ala Met Thr  Thr Glu Glu Arg Asp  Ser Leu Gly 
    1100                 1105                 1110             


Ala Gly  His Val Lys Asp Asp  Ser Gln Phe Ala Tyr  Ile Gly Phe 
    1115                 1120                 1125             


Ala Asp  Val Cys Val Lys Leu  Gly Leu Ser Pro Ser  Leu Thr Thr 
    1130                 1135                 1140             


Met Val  Arg Ser Ile Arg Asn  Thr Thr Leu His Ala  Asp Leu Pro 
    1145                 1150                 1155             


Met Gly  Trp Thr Tyr Glu Glu  Tyr Glu Lys Asp Pro  Val Leu Phe 
    1160                 1165                 1170             


Ala Val  Leu Gly His Val Pro  Lys Gln Pro Arg Ala  Pro Lys Pro 
    1175                 1180                 1185             


Ser Glu  Val Gln Ala Glu Glu  Gly Lys 
    1190                 1195         


<210>  2527
<211>  1175
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2527

Met Thr Glu Gln Asn Glu Arg Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Phe Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Ala His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Met Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Lys Tyr Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Glu Lys Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Ala Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Gly Gly Thr 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Leu Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Glu Glu Val 
            500                 505                 510         


Ser Ala Glu Lys Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Asp Glu Ile Asn Thr Arg Asp 
    530                 535                 540                 


Glu Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Ile Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Ser His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Ser Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Tyr Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Asp Leu Glu Ala Trp Ser His Ser Ala Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Val Gly Ile Glu Tyr Ala Ser Trp Glu Asn 
    850                 855                 860                 


Lys Thr Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Lys Ala 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Lys Ala Asp Lys Ile Asn Ile Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Ala Lys Glu His Pro Tyr His Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu Arg Leu Val Lys Asn Gln 
        915                 920                 925             


Asp Ile Ile Thr Trp Met Met Cys Arg Asp Leu Met Glu Glu Asn Lys 
    930                 935                 940                 


Val Glu Gly Leu Asp Thr Gly Thr Leu Tyr Leu Lys Asp Ile Arg Thr 
945                 950                 955                 960 


Asp Val Gln Glu Gln Gly Ser Leu Asn Val Leu Asn Arg Val Lys Pro 
                965                 970                 975     


Met Arg Leu Pro Val Val Val Tyr Arg Ala Asp Ser Arg Gly His Val 
            980                 985                 990         


His Lys Glu Glu Ala Pro Leu Ala  Thr Val Tyr Ile Glu  Glu Arg Asp 
        995                 1000                 1005             


Thr Lys  Leu Leu Lys Gln Gly  Asn Phe Lys Ser Phe  Val Lys Asp 
    1010                 1015                 1020             


Arg Arg  Leu Asn Gly Leu Phe  Ser Phe Val Asp Thr  Gly Gly Leu 
    1025                 1030                 1035             


Ala Met  Glu Gln Tyr Pro Ile  Ser Lys Leu Arg Val  Glu Tyr Glu 
    1040                 1045                 1050             


Leu Ala  Lys Tyr Gln Thr Ala  Arg Val Cys Ala Phe  Glu Gln Thr 
    1055                 1060                 1065             


Leu Glu  Leu Glu Glu Ser Leu  Leu Thr Arg Cys Pro  His Leu Pro 
    1070                 1075                 1080             


Asp Lys  Asn Phe Arg Lys Met  Leu Glu Ser Trp Ser  Asp Pro Leu 
    1085                 1090                 1095             


Leu Asp  Lys Trp Pro Asp Leu  His Arg Lys Val Arg  Leu Leu Ile 
    1100                 1105                 1110             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1115                 1120                 1125             


Glu Ala  Val Phe Ser Ser Ile  Arg Lys Tyr Asp Pro  Ser Ser Leu 
    1130                 1135                 1140             


Asp Ala  Ile Glu Glu Arg Met  Gly Leu Asn Ile Ala  His Arg Leu 
    1145                 1150                 1155             


Ser Glu  Glu Val Lys Gln Ala  Lys Glu Met Ala Glu  Arg Ile Ile 
    1160                 1165                 1170             


Gln Val  
    1175 


<210>  2528
<211>  1091
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2528

Met Asn Asn Lys His Val Phe Ala Ala Tyr Leu Asn Gln Ala Thr His 
1               5                   10                  15      


Asn Tyr His Leu Leu Leu Asn Asp Ile Ser Gln Lys Ile Gly Lys Thr 
            20                  25                  30          


Met Leu Glu Asp Glu Asn Leu Gln Val His Pro Val Ile Ser Leu Leu 
        35                  40                  45              


Ala Asp Ser Lys Asp Ala Arg Leu Ser Leu Arg Ala Ile Asn Ser Phe 
    50                  55                  60                  


Asn Lys Gly Phe Gly Phe Ile Glu Lys Leu Gln Arg Arg Ile Met Ala 
65                  70                  75                  80  


Tyr Arg Tyr Leu Ser Ala Lys Lys Ser Glu Pro Glu Asp Asn Ala Lys 
                85                  90                  95      


Pro Lys Lys His Ile Lys Lys Ser Gln Glu Tyr Ser Leu Leu Pro Ala 
            100                 105                 110         


Asp Tyr Ala Tyr Gln Leu Lys Ser Leu Ala Ser Thr Leu Asn Asp Glu 
        115                 120                 125             


Arg Asn His Ala Thr His Ala Tyr Leu Gln Pro Val Lys Pro Asp Ala 
    130                 135                 140                 


Asn Leu Ile Glu Phe Leu Tyr Asp Ile Phe Asp Met Ala Val Arg Val 
145                 150                 155                 160 


Cys Lys Ile Arg His Gln Ile Asp Glu Asn Asp Leu Lys His Leu Arg 
                165                 170                 175     


Arg Lys Met Arg Asn Pro Asp Lys Ser Lys Asp Ala Pro Lys Ser Ile 
            180                 185                 190         


Phe Asp Pro Lys Phe Lys Tyr Pro Phe Leu Asp Lys Gln Gly Gln Phe 
        195                 200                 205             


Thr Asp His Gly Arg Ala Phe Leu Thr Cys Leu Phe Leu Asn Lys Gln 
    210                 215                 220                 


Asp Ser Tyr Gln Phe Leu Lys Gln Leu Ser Gly Phe Lys Ser Ser Asn 
225                 230                 235                 240 


Ser Asn Thr His Lys Ala Thr Leu Arg Val Phe Ser Cys Phe Ser Ile 
                245                 250                 255     


Arg Leu Pro Asn Glu Arg Ile Asn Ser Thr Thr Asp Ala Gln Thr Leu 
            260                 265                 270         


Gly Leu Asp Met Leu Asn Glu Leu Ala Arg Cys Pro Ser Leu Leu Phe 
        275                 280                 285             


Pro Val Leu Pro Lys Ile Glu Lys Thr Ile Tyr Glu Ile Pro Val Glu 
    290                 295                 300                 


Val Asn Glu Gln Asn Asn Ser Asp Asp Gly Asn Asp Leu Leu Phe Ile 
305                 310                 315                 320 


Arg His Asp Glu Arg Phe Ile Ser Leu Met Met Arg Tyr Phe Asp Glu 
                325                 330                 335     


Thr Asn Ala Phe Glu Lys Leu Arg Phe His Ile Asp Leu Gly Asp Phe 
            340                 345                 350         


Tyr Phe Ala Ala Tyr Leu Lys Thr Leu Tyr Glu Asp Val Gln Asp Thr 
        355                 360                 365             


Arg Arg Leu Lys Gln Lys Leu His Thr Phe Ala Arg Leu Asn Glu Val 
    370                 375                 380                 


Glu Asn Thr Ala Ile Pro Ala Glu Trp Gln Thr Leu Ile Arg Asp Asn 
385                 390                 395                 400 


Arg Glu Ile Thr Glu Thr Asp Leu Asn Pro Tyr Leu Val Asn Thr Thr 
                405                 410                 415     


Pro His Tyr His Leu Leu Asp Asp Asn Ile Ala Leu Lys Ile Val Gly 
            420                 425                 430         


Pro Asn Thr Val Ile Tyr Pro Lys Leu Thr Pro His Asp Ser Ile Glu 
        435                 440                 445             


Asn Arg Tyr Lys Ser Pro Glu Asn Gln Gln Pro Asp Phe Trp Leu Ser 
    450                 455                 460                 


Lys His Glu Met Leu His Leu Ala Phe Tyr Gln Leu Leu Arg Gln Lys 
465                 470                 475                 480 


His Thr Gln Leu Asn Arg Gly Gln Ile Glu Asp Thr Val Phe Ala Gln 
                485                 490                 495     


Tyr Lys Gln Ala Leu His His Cys Leu Asp Gln Leu Ala Glu Asn Pro 
            500                 505                 510         


Glu Arg Tyr Thr Ser Lys Glu Ala Ile His Asp Leu Ala Gln Gln Tyr 
        515                 520                 525             


Thr Tyr Ser Pro Leu Lys Gln Ala Met Met Leu Asp Glu Ile Pro Lys 
    530                 535                 540                 


Val Val Arg Asp Ala Leu Ile Lys Lys Asp Ser Arg Tyr Gln Asn Ser 
545                 550                 555                 560 


Ala Leu Thr Ala Ile Ser Thr Leu Ile Asn Ile Gly Glu Lys Arg Leu 
                565                 570                 575     


Asp Ala Leu Lys Arg Ser Thr Ser Thr Asp Lys Lys Asp Lys Ser Thr 
            580                 585                 590         


Arg Pro Gly Asp Lys Lys Gln Arg Pro Val Lys Ala Gly Leu Met Gly 
        595                 600                 605             


Glu His Leu Ala Glu Asp Ile Val Arg Phe Gln Pro Ala Gln Asp Asp 
    610                 615                 620                 


Ser Asp Asn Lys Gly Lys Pro Thr Ser Leu Ile Val Ala Glu Leu Gln 
625                 630                 635                 640 


Ala Arg Leu Ala Phe Tyr Gly Arg Asp Lys Ala Gln Leu Pro Ala Leu 
                645                 650                 655     


Cys Lys Ala Met Lys Leu Ile Asp Asn Val Asp Thr Ser Lys Asn His 
            660                 665                 670         


Pro Phe Leu Ala Ala Val Leu Lys Glu Asn His Ala Gly Ile Ile Gly 
        675                 680                 685             


Phe Tyr Gln Ser Tyr Tyr Arg Ala Arg Ala His Tyr Leu Gln Arg Val 
    690                 695                 700                 


Glu Ala Asp Ile Thr Gln Asn Thr Ser His Ile Ser Arg Tyr His Trp 
705                 710                 715                 720 


Leu Lys Thr Pro Thr Arg Asp Lys Pro Asp Phe Ser Ile Lys Ser His 
                725                 730                 735     


Val Lys Lys Leu Lys Ala Gln Pro Val Asn Leu Pro Arg Gly Leu Phe 
            740                 745                 750         


Leu Pro Tyr Ile Lys His Ala Leu Leu Gln Leu Asn His Asp Thr Leu 
        755                 760                 765             


Thr Pro Ala Ile Glu Lys Ser Ala Thr Leu Asn Thr Ser Tyr Leu Ile 
    770                 775                 780                 


Ala Leu Tyr Tyr Gln His Val Leu Gln Asp Lys Pro Gln Ala Val Tyr 
785                 790                 795                 800 


Glu Lys Pro Arg Glu Tyr Lys Ile Ile Ala Gln Thr Phe Asp Asn Arg 
                805                 810                 815     


Thr Asn Gln Phe Lys Pro Leu Pro Ala His Pro Thr Gln Thr Gln Gln 
            820                 825                 830         


Ala Tyr Gly Thr Thr Asn Ala Leu His Thr Lys Ile Lys Gln His Leu 
        835                 840                 845             


Gln Ala Lys Tyr Pro Asp Glu Asp Lys Thr Gln Gln Leu Ala Ala Tyr 
    850                 855                 860                 


Arg Lys Phe Glu Gln Tyr Glu Lys Asn Ile Arg Gln Ile Arg Thr Gln 
865                 870                 875                 880 


Asp Gln Val Leu Phe Leu Ala Cys Gln Gln Leu Leu Ala Leu Asn His 
                885                 890                 895     


Gly Leu Asn Gln Glu Ile Ser Gln Leu Lys Leu His Gln Leu Asp Lys 
            900                 905                 910         


Thr Leu Leu Asp Lys Gln Thr His Tyr Gln Leu His Ile His Gly Lys 
        915                 920                 925             


Thr Ile Ser Gln Ala Gln Ile Arg Ile Lys Lys Ile Gly Glu Phe Arg 
    930                 935                 940                 


Arg Phe Leu Lys Asp Arg Arg Leu Lys Gly Leu Leu Ser Tyr Tyr Gly 
945                 950                 955                 960 


Gln His Asp Ile Pro Arg Glu Val Ile Ala Lys Glu Leu Glu Glu Tyr 
                965                 970                 975     


Gln His Cys Arg Leu Lys Val Phe Glu Arg Leu His Ala Phe Glu Gln 
            980                 985                 990         


Phe Ser Tyr Gln His Phe Gly Leu  Asp Ala Gln Tyr Gln  Gly Ser Glu 
        995                 1000                 1005             


His Gly  Gln Leu Leu Ser Ala  Tyr Phe Lys Ala Asn  Pro Gln Ala 
    1010                 1015                 1020             


Asn His  Glu Ala Gln Met His  Cys Met Leu Val Leu  Arg Asn Ala 
    1025                 1030                 1035             


Phe Ala  His Asn Gln Tyr Pro  Met Pro Gln Ser Lys  Tyr Pro Leu 
    1040                 1045                 1050             


Ala Asn  Ala Met Leu Thr Gln  Ala Gln Gln His Leu  Thr Gln Ser 
    1055                 1060                 1065             


Gly Ala  Pro Gln Val Ala Gln  Tyr Leu Leu Gln Gln  Val Glu Ala 
    1070                 1075                 1080             


Phe Tyr  Pro Asn Pro Ile Thr  Thr 
    1085                 1090     


<210>  2529
<211>  1246
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2529

Met Arg Leu Asp Gln Ala Val Leu Ala Ala Phe Tyr Asn Asp Ala Arg 
1               5                   10                  15      


Leu Asn Ile Leu Ser Cys Leu Asn Asp Ile Arg Glu Lys Gln Gly Leu 
            20                  25                  30          


Ser Phe Ile Gly Asp Asp Ala Gln Ile Val Ser Ala Phe Tyr Asp Leu 
        35                  40                  45              


Ser His Ile Leu Thr Gln Gly Thr Pro Glu Glu Ala Ser Ala Leu Ile 
    50                  55                  60                  


Asp Arg Leu Arg Tyr Arg Phe Pro Phe Ile Asp Thr Arg Thr Asp Ala 
65                  70                  75                  80  


Ser Ser Arg His Lys Asp Phe Thr Pro Val Pro Asp Asn Phe Gln His 
                85                  90                  95      


Ile Phe Gln Arg Ile Phe Lys Leu Ile Asn Ser Leu Arg Asn Thr Leu 
            100                 105                 110         


Val His Pro Val Asn Ser Pro Leu Leu Leu Asp Met Asp Gln His Lys 
        115                 120                 125             


Asn Leu Phe Phe Met Leu Asn Asp Ile Tyr Asp Asp Ala Arg Arg Leu 
    130                 135                 140                 


Leu Lys Thr Arg Phe Asp Trp Ser Thr Arg Asp Ile Glu Pro Leu Leu 
145                 150                 155                 160 


Arg His Asp His Lys Gly Lys Pro Lys Leu Val Asn Lys Phe Ser Phe 
                165                 170                 175     


Ala Leu Cys Ser Ala Pro Gly Ser Asp Pro Lys Ser Arg Ser Asn Ser 
            180                 185                 190         


Pro Val Ile Gly Tyr Asn Arg Val Leu Tyr Asp Phe Gly His Val Leu 
        195                 200                 205             


Leu Cys Ser Leu Phe Leu Asp Lys Ser Gln Ser Ala Asp Leu Ile His 
    210                 215                 220                 


Tyr Phe Trp Gln Ser Gly His Gly Lys Phe Trp Gln Ser Gln Lys His 
225                 230                 235                 240 


Arg Glu Met Ile Lys Glu Leu Ile Ser Ala Tyr His Ile Arg Leu Pro 
                245                 250                 255     


Leu Gln Arg Leu Lys Ala Asp Ser Leu Thr Thr Leu Thr Ile Asp Ala 
            260                 265                 270         


Leu Ser Glu Leu Ser Arg Cys Pro Gln Pro Leu Leu Lys Thr Leu Lys 
        275                 280                 285             


Lys Glu Asp Lys Asp Lys Phe Arg Glu Ala Leu Gly Thr Leu Asp Asn 
    290                 295                 300                 


Ile Asp Ile Ser Asp Asp Ala Gly Asn Gly Ala Gly Asn Ala Ala Ala 
305                 310                 315                 320 


Asn Ser Ala Arg Lys Gln Ser Gln Ala Glu Gln Gln Ala Ser Tyr Leu 
                325                 330                 335     


Leu Ala Arg Ser His Glu Asp Arg Phe Val Pro Leu Met Met Arg Phe 
            340                 345                 350         


Leu Glu His Asp Pro Ala Asn Lys Leu Arg Phe Ala Ile Asp Leu Gly 
        355                 360                 365             


Gln Phe Tyr Tyr His Val Arg Leu Lys Ser Gly Asp Phe Phe Thr Asp 
    370                 375                 380                 


Asn Lys Pro Arg Val Arg Arg Leu Gly Gln Lys Leu Ile Cys Tyr Gly 
385                 390                 395                 400 


His Leu Asn Asn Leu Asn Lys Ser Asp Phe Trp Gln Gln Leu Glu Asp 
                405                 410                 415     


Asn Phe Ala Leu Ser Ser Gln Glu Ala Lys Gln Ala Glu Thr Leu Ala 
            420                 425                 430         


Ser Ala Glu Pro Leu Gln Leu Lys Pro Tyr Leu Val Lys Thr Ile Pro 
        435                 440                 445             


His Tyr His Phe Asp Asn Asn Lys Ile Gly Ile Arg Leu Ala Gln Ser 
    450                 455                 460                 


Thr Gly Lys Ser Thr Asp Lys Arg Ala Asn Lys Ser Ala Asn Gln Lys 
465                 470                 475                 480 


Thr Asp Tyr Pro Lys Tyr Pro Glu Asp Lys Gly Ile Ser Val Glu Asp 
                485                 490                 495     


Ile Arg Gln Pro Ile Gln Leu Asp Lys Ile Pro Ala Glu Gln Met Gln 
            500                 505                 510         


Ala Glu Phe Trp Ile Ser Pro Ala Gln Met Leu His Ile Gly Phe Tyr 
        515                 520                 525             


His Tyr Leu Tyr Gln His Gln Gln Asn Ala Thr Ser Gly Lys Ala Thr 
    530                 535                 540                 


Gln Ser Lys Ser Ile Glu Val Leu Leu Asn Thr Tyr Lys Ala Gly Thr 
545                 550                 555                 560 


Leu Arg Leu Phe Lys Ala Leu Lys Lys Gln Met Pro Glu Leu Ala Gly 
                565                 570                 575     


Glu Ala Phe Ser Ala Glu Arg His Gln Ala Val Gln Asp Tyr Ile Asn 
            580                 585                 590         


Gly Phe Tyr Ala Ala Lys Gly Asn Asn Ser Asp Asn Ser Asp Tyr His 
        595                 600                 605             


Ile Ser Met Ala Asn Leu Pro Lys Val Leu Val Asn Ala Leu Leu Gly 
    610                 615                 620                 


Ala Gln Gln Gln Gln Val Ile Pro Lys Gln Gln Ile Ile Asp Arg Ala 
625                 630                 635                 640 


Asn Lys Leu Leu Gln Ser Thr Glu Gln Arg Gln Arg Gln Leu Glu Arg 
                645                 650                 655     


Gln Leu Asn Ala Phe Lys Lys Arg Gly His Lys Asp Phe Arg Pro Ile 
            660                 665                 670         


Lys Cys Gly Asn Ile Gly Asp Phe Leu Thr Asp Asp Ile Ile Arg Phe 
        675                 680                 685             


Gln Ala Val Asp Pro Ser Gln Asn Asp Gly Gly Lys Leu Asn Ser Gln 
    690                 695                 700                 


Gln Tyr Gln Ile Leu Gln Lys Thr Leu Ala Tyr Tyr Gly Lys Tyr Ile 
705                 710                 715                 720 


Asp Glu Pro Pro Gln Ile Ile Asp Leu Phe Gln Asp Phe Gly Leu Ile 
                725                 730                 735     


Glu Gly Asp Phe Lys His Pro Phe Leu Asp Lys Leu Gly Leu Gln Lys 
            740                 745                 750         


Asn Pro His Lys Tyr Lys Gly Leu Leu Asp Phe Tyr Lys Asp Tyr Leu 
        755                 760                 765             


Lys Tyr Arg Lys Ala Tyr Ile Lys Glu Tyr Leu Asn Gln Val Ser Ser 
    770                 775                 780                 


His Ser Asn Asn Asp Asp Arg Gln Gln His Gln Gln His Gln Gln Asn 
785                 790                 795                 800 


Gln Gln Gln Pro Leu Gln Ala Ala His Trp Leu Arg Leu Lys Lys Leu 
                805                 810                 815     


Ser Thr Leu Asp Gly Phe Phe Lys Glu Asn Leu Thr Asp Asn Glu Thr 
            820                 825                 830         


Leu Ala Gln Pro Leu Pro Leu Ala Lys Asp Phe Phe Tyr Lys Pro Ile 
        835                 840                 845             


Leu Asn Leu Leu Ala Asp Ala Leu Asn Ile Ser Pro Glu Thr Ile Glu 
    850                 855                 860                 


Gln Glu Gly Met Gln Thr Phe Thr Arg Asn Asn Lys Thr Val Lys Ile 
865                 870                 875                 880 


Arg Pro Ala Ile Ser Trp Met Ile Lys Tyr Tyr His Gln His Lys Asn 
                885                 890                 895     


Leu Asp Gly Asn Lys Asp Gly Asn Glu Asp Gly Asp Asp Ser Ser Asp 
            900                 905                 910         


Asp Val Gln Thr Met Tyr Thr Phe Glu Arg Ser His Lys Val Phe Asn 
        915                 920                 925             


Tyr Phe Leu Asp Lys Arg Gly Lys Lys Asn Lys Tyr Lys Glu Lys Val 
    930                 935                 940                 


Ser His Tyr Leu Ser Glu Gln Asp Arg Lys Arg Tyr Leu Pro Glu Ile 
945                 950                 955                 960 


Arg Glu Lys Ile Ser Ser Leu Arg Ala Met Val Asn Gln Gln Lys Thr 
                965                 970                 975     


Asn Lys Lys Gln Pro Lys Asp Asn Ile Ser Asp Glu Glu Lys Leu Ser 
            980                 985                 990         


Asn Lys Leu Gln Ser Glu Leu Lys  Ser Tyr Lys His Gln  Glu Lys Ile 
        995                 1000                 1005             


Ile Arg  His Thr Ala Ile Gln  Asp Ile Leu Leu Ser  Leu Tyr Val 
    1010                 1015                 1020             


Arg Gln  Tyr Leu Asp Arg Leu  Met Gln Asn Gln Asn  Pro Val Asn 
    1025                 1030                 1035             


Trp Lys  Leu Lys Asp Ile Glu  Asn Thr Leu Leu Asn  Gln Pro Ile 
    1040                 1045                 1050             


Tyr His  Glu Phe Ser Val Pro  Asp Ser Ser Lys Lys  Leu Phe His 
    1055                 1060                 1065             


Pro Ala  Cys Lys Ile Arg Lys  Leu Gly Glu Leu Arg  Leu Leu Ala 
    1070                 1075                 1080             


Arg Asp  Arg Arg Leu Pro Ser  Leu Leu Asp Tyr Tyr  Pro Glu Glu 
    1085                 1090                 1095             


Glu Ser  Leu Ile Asn Gln Ala  Glu Ile Arg Ala Glu  Leu Tyr Asn 
    1100                 1105                 1110             


Tyr Arg  Arg Ala Arg Val Asp  Val Met Lys Leu Ala  His Ser Leu 
    1115                 1120                 1125             


Glu Gln  Gln Ile Val Lys Lys  Tyr Gly Met Pro Lys  Asp Glu Glu 
    1130                 1135                 1140             


Ala Pro  Lys Glu Gln Gln Lys  Phe Phe Gly Ala Gly  Arg His Gly 
    1145                 1150                 1155             


Ala Phe  Leu His Leu Leu His  Glu Ser Met Gly Val  Gln Val Asn 
    1160                 1165                 1170             


Asp Thr  Asn Gly Asp Lys Thr  Arg Ile Lys Gln Ala  Leu Ala Ile 
    1175                 1180                 1185             


Arg Asn  Ala Phe Ser His Ser  Glu Tyr Pro Asp Thr  Asn Thr Leu 
    1190                 1195                 1200             


Pro Gln  Val Lys Asp Ala Ile  Ala Ser Glu Ala Ile  Pro Val Asn 
    1205                 1210                 1215             


Pro Ala  Gln Asn Arg Lys Ile  Ala Leu Lys Leu Val  Ala Glu Met 
    1220                 1225                 1230             


Glu Arg  Leu Tyr Gln Pro Trp  Leu Lys Phe Leu Lys  Asp 
    1235                 1240                 1245     


<210>  2530
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2530

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Ala Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Asn Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2531
<211>  1075
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2531

Met Asn Thr His Gln Glu Glu Leu Gln Ser Trp Ile Thr Arg Lys Arg 
1               5                   10                  15      


Leu Pro Asp Thr Glu Met Lys Lys Tyr Trp Ala Ala Tyr Met Asn Leu 
            20                  25                  30          


Ala Arg Leu Asn Phe Phe Lys Thr Leu Met Phe Ile Ser Asn Ser Ile 
        35                  40                  45              


Gly Asp Leu Lys Pro Ala Lys Asp Asn Asn Gly Lys Gly Asn Thr Glu 
    50                  55                  60                  


Val Asn Met His Asn Met Gly Ile Leu Thr Ala Leu Leu Gly Pro Glu 
65                  70                  75                  80  


Asp Glu Glu Lys Ala Arg Leu Leu Ile Phe Lys His Phe Pro Phe Leu 
                85                  90                  95      


Arg Thr Phe Cys Ile Glu Lys Glu Leu Ser Leu Ser Lys Gln Arg Thr 
            100                 105                 110         


Ile Leu Ile Asp Met Ala Cys Ile Ile Gly Arg Tyr Arg Asn Met Tyr 
        115                 120                 125             


Ser His Ser Ile Phe Ile Ser Asp Asp Asn Glu Lys Val Leu Glu Ser 
    130                 135                 140                 


Glu Lys Arg Cys Ser Glu Tyr Leu Gln Ser Ile Leu Thr Val Ser Thr 
145                 150                 155                 160 


Arg Ile Ile Lys Glu Arg Tyr Arg Ser Asn Lys Asn Asp Ala Gln Arg 
                165                 170                 175     


Gly Met Ile Asp Asp Lys Ser Leu Lys Phe Ile Ser Glu Asn Lys Val 
            180                 185                 190         


Lys Phe Val Tyr Asp Glu Asn Gly Lys Arg Ile Thr Ala Pro Asn Lys 
        195                 200                 205             


Lys Tyr Tyr Leu Ser Thr Ile Asp Lys Asp Asn Thr His Leu Ser Tyr 
    210                 215                 220                 


Phe Gly Lys Leu Met Leu Thr Cys Ile Leu Leu Glu Lys Lys Tyr Ala 
225                 230                 235                 240 


Thr Asp Phe Leu Thr Gln Cys His Phe Leu Asp Ala Phe Asn Asp Ser 
                245                 250                 255     


Glu Val Ala Pro Lys Leu Ser Glu Arg Arg Leu Met Leu Glu Val Met 
            260                 265                 270         


Thr Ala Leu Arg Ile Arg Leu Ala Glu Lys Lys Leu Ser Asn Glu Lys 
        275                 280                 285             


Ser Glu Val Gln Ile Ser Leu Asp Ile Leu Asn Glu Leu Lys Lys Cys 
    290                 295                 300                 


Pro Phe Glu Leu Tyr Glu Leu Leu Gly Ser Glu Asp Lys Arg Leu Phe 
305                 310                 315                 320 


Thr Ile Val Ala Asp Thr Gly Glu Thr Ile Leu Leu Arg Arg His Glu 
                325                 330                 335     


Asp Arg Phe Pro Gln Leu Ala Leu Ser Trp Ile Asp Ser Ser Lys Ala 
            340                 345                 350         


Phe Asp His Leu Arg Phe Gln Val Asn Ala Gly Lys Leu Arg Tyr Leu 
        355                 360                 365             


Phe Arg Asp Asn Lys His Cys Ile Asp Gly Gln Thr Arg Met Arg Val 
    370                 375                 380                 


Leu Glu Glu Pro Leu Asn Gly Tyr Arg Arg Leu Met Glu Phe Glu Glu 
385                 390                 395                 400 


Glu Arg Ile Gln Lys Gln Ser Gly Glu Ile Arg Ser Leu Trp Pro Gly 
                405                 410                 415     


Leu Asp Ile Leu Asn Lys Asp Glu Thr Pro Arg Asn Asp Ala Ser Val 
            420                 425                 430         


Leu Pro Tyr Ile Ser Asp Tyr Arg Val Arg Tyr Leu Phe Asp Gly Asp 
        435                 440                 445             


Asn Ile Gly Ile Ser Ile Gly Asp Phe Thr Pro Ser Ile Thr Lys Thr 
    450                 455                 460                 


Asp Glu Thr Lys Tyr Arg Val Thr Gly Lys Thr Ala Asp Cys Cys Leu 
465                 470                 475                 480 


Ser Lys Tyr Glu Leu Pro Gly Leu Leu Phe Tyr His Leu Leu Thr Leu 
                485                 490                 495     


Arg His Gly Asp Asn Lys Arg Ser Thr Lys Asn Ala Glu Asp Ile Ile 
            500                 505                 510         


Ile Asp Ala Ile Lys Arg Tyr Lys Arg Leu Phe Ser Asp Val Lys Glu 
        515                 520                 525             


Gly Ile Leu Lys Pro Ile Lys Glu Glu Asn Ala Asn Gln Leu Gly Asn 
    530                 535                 540                 


Arg Ile Trp Asn Ser Tyr Gly Ile Asn Ile Lys Asp Ile Pro Asp Lys 
545                 550                 555                 560 


Ile Ile Asp Tyr Leu Leu Val Arg Glu Cys Asn Glu Asp Glu Lys Phe 
                565                 570                 575     


Thr Ala Trp Lys Asn Gly Phe Ile Ser Glu Met Leu Gln Ser Thr Lys 
            580                 585                 590         


Asn Arg Ile Lys Arg Phe Glu Lys Asp Ser Glu Ala Val Ile Ser Ser 
        595                 600                 605             


Asp Asn Lys Pro Gly Lys Lys Asn His Val Ser Leu Lys Pro Gly Ala 
    610                 615                 620                 


Tyr Ala Ser Phe Ile Ala Asn Asp Ile Val Phe Phe Gln Glu Cys Gly 
625                 630                 635                 640 


Ala Thr Glu Lys Met Thr Gly Leu Asn Phe Lys Val Met Gln Ser Arg 
                645                 650                 655     


Leu Ala Thr Phe Thr Lys Asp Gly Ser Thr Ser Phe Asn Ile Leu Leu 
            660                 665                 670         


Gln Thr Leu Lys Asn Ala His Leu Val Ser Thr Thr Tyr Gly Lys Gly 
        675                 680                 685             


Asp His Pro Phe Leu Tyr Arg Val Ile Lys Gln Gln Pro Ser Asp Ile 
    690                 695                 700                 


Val Gln Phe Tyr Lys Ile Tyr Leu Asn Glu Lys Val Leu Tyr Leu Gln 
705                 710                 715                 720 


Ser Asp Ile Pro Asp Asn Ala Ile Phe Leu His Gly Glu Arg Lys Arg 
                725                 730                 735     


Trp Glu Asn Arg Asn Glu Gln Tyr Tyr Arg Asp Leu Ala Glu Arg Tyr 
            740                 745                 750         


Leu Gln Arg Pro Ile Gln Leu Pro Arg Gln Leu Phe Glu Ser His Ile 
        755                 760                 765             


Arg Gln Leu Leu Leu Ser Asp Cys Ile Lys Gly Glu Arg Gly Asn Asp 
    770                 775                 780                 


Leu Lys Glu Ala Ile Asn Ser Ala Ala Ser Gln Gly Arg Cys Asn Thr 
785                 790                 795                 800 


Thr Tyr Met Ile Met Glu Tyr Phe Ala Asp Tyr Leu Cys Asp Gly Thr 
                805                 810                 815     


Gln Phe Phe Tyr Gly Leu Phe Asp Gly Asp Leu Ser His Glu Tyr Asn 
            820                 825                 830         


Tyr Arg Phe Tyr Ser Leu Ile Ser Asn Asn Ile Glu Asn Ser Lys Lys 
        835                 840                 845             


Leu Val Leu Thr Leu Lys Lys Gly Asn Asn Ser Lys Glu Ser Pro Phe 
    850                 855                 860                 


Ile Ser Ala Leu Glu Arg Gly Ile His Trp Ser Lys Met Asn Pro Leu 
865                 870                 875                 880 


Met Lys Lys Gly Leu Lys Asn Asp Ser Ser Glu Gly Asp Phe Val His 
                885                 890                 895     


Ala Ala Lys Arg Ala Tyr Lys Glu Met Thr Glu Thr Glu Arg Met Phe 
            900                 905                 910         


Arg Arg Tyr Ala Val Gln Asp Glu Val Leu Phe Leu Ala Ala Lys Ile 
        915                 920                 925             


Thr Ile Arg Arg Val Leu Gly Leu Ser Glu Gln Tyr Asn Cys Leu Leu 
    930                 935                 940                 


Gly Asp Ile Lys Pro Gln Gly Gly Ser Leu Leu Glu Gln Thr Ile Pro 
945                 950                 955                 960 


Ser Ile Thr Thr Lys His Thr Ile Asn Thr Gly Asn Lys Lys Gln Lys 
                965                 970                 975     


Pro Lys Gln Val Gln Ile Leu Gln Lys Asn Val Lys Leu Lys Asp Phe 
            980                 985                 990         


Gly Lys Val Phe Lys Leu Leu Asn  Asp Arg Arg Ile Phe  Asp Leu Leu 
        995                 1000                 1005             


Phe Asn  Lys Gly Asn Glu Ala  Val Ser Met Thr Asp  Leu Cys Glu 
    1010                 1015                 1020             


Glu Leu  Glu Arg Tyr Asp Arg  His Arg Val Asp Val  Phe Asp Ser 
    1025                 1030                 1035             


Val Leu  Lys Tyr Glu Ser Lys  Ile Thr Lys Gly Tyr  Thr Asn Lys 
    1040                 1045                 1050             


Glu Leu  Met Asn Glu Ser Gly  Gln Ile Asp Phe Lys  Ala Ile Gln 
    1055                 1060                 1065             


Ala Phe  Asp Lys Gln Asn Thr  
    1070                 1075 


<210>  2532
<211>  1197
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2532

Met Ser Asn Asn Phe Arg Thr Gln Ser Thr His Arg Pro Pro His Leu 
1               5                   10                  15      


Gln Lys Thr Thr Pro Pro Ser Lys Leu Glu Thr Trp Thr Gly Gly Lys 
            20                  25                  30          


Arg Pro Glu Leu Ala Val Phe Tyr Asn Val Ala Tyr Phe Arg Ile Ala 
        35                  40                  45              


Gly Met Leu Ser His Tyr Leu Asn Lys Thr His Glu His Asp Lys Asp 
    50                  55                  60                  


Ala Leu Glu Leu Leu Phe Lys Lys Val Val Ser Gly Glu Asp Gln Leu 
65                  70                  75                  80  


Ser Asp Ala Val Cys Ser Lys Leu Arg Asp Tyr Leu Trp Lys Ser Tyr 
                85                  90                  95      


Thr Thr Gln Gln Glu Asn Ser Ser Gly Tyr Ala Leu Asn Gln Glu Asp 
            100                 105                 110         


Arg Asp Leu Val Leu Leu Met Leu Arg Lys Leu Gln Asp Val Arg Asn 
        115                 120                 125             


Phe Gln Ser His Val Trp His Asp Asn Arg Ala Leu Val Phe Pro Val 
    130                 135                 140                 


Lys Leu Cys Ala His Ile Glu Arg Met His Glu Ala Ala Asn Met Ala 
145                 150                 155                 160 


Gln Gly Ile Asp Met Ala Ser Ala Val Val Thr Tyr His Asp Asn Tyr 
                165                 170                 175     


Lys Val Tyr Asp Ser Thr Met Arg Phe Asn Gln Gly Arg Lys Asp Leu 
            180                 185                 190         


Gln Ala Phe Phe Asp Arg Trp Asp Thr Asp His Tyr Ile Thr Gln Glu 
        195                 200                 205             


Gly Arg Ile Phe Phe Leu Ser Phe Phe Leu Thr Arg Ser Glu Met Ala 
    210                 215                 220                 


Arg Leu Leu Gln Gln Ser Lys Gly Ser Lys Arg Asn Asp Lys Pro Glu 
225                 230                 235                 240 


Phe Lys Ile Lys His Ala Ile Tyr Arg Tyr Phe Thr His Arg Asp Ala 
                245                 250                 255     


Ala Ser Arg Asn His Tyr Gly Leu Asn Asp Asn Ile Leu Ser Glu Leu 
            260                 265                 270         


Pro Asn Glu Gln Arg Ala Gln Ile Met Ala Ala Arg Gln Val Tyr Lys 
        275                 280                 285             


Ile Ile Asn Tyr Leu Asn Asp Ile Pro Tyr Arg Ser His Asp Pro Ala 
    290                 295                 300                 


Leu Phe Pro Leu Phe Leu Ala Asp Gly Thr Glu Ala Leu Asp Glu His 
305                 310                 315                 320 


Gly Leu Leu Gln Trp Lys Lys Glu Thr Asp Phe Leu Pro Glu Ile Thr 
                325                 330                 335     


Ala Lys Ala Arg Lys Val Pro Ala Leu Ser Glu Thr Glu Arg Phe Gly 
            340                 345                 350         


Val Arg Gly Arg Lys Ala Thr Lys Ala Ile Asp Asp Arg Thr Leu Glu 
        355                 360                 365             


Val Glu Arg Gly Phe Glu Leu Gln Trp Val Gly Asn Asp Arg Tyr Asn 
    370                 375                 380                 


Phe Thr Ile Pro Thr Arg His Phe His Arg Cys Ala Leu Asp Ala Ile 
385                 390                 395                 400 


Arg Asn Gly Asp Lys Gly Ala Thr Phe Ala Asp Arg Leu Lys Val Phe 
                405                 410                 415     


Ile Gly Asp Arg Glu His Leu Leu Asp Arg Leu His Lys Glu Phe Thr 
            420                 425                 430         


Ile Leu Pro Leu Arg Gln Ala Asp Phe Thr Leu Glu Lys Glu Leu Asp 
        435                 440                 445             


Glu Tyr Tyr Lys Phe Arg Leu Arg Gly Asp Gly Lys Leu Thr Lys Ser 
    450                 455                 460                 


Leu Gly Gln Trp Leu Asp Ala Ile Asp Arg Gln Asn Val Arg Lys Tyr 
465                 470                 475                 480 


Pro Glu Ala Leu Ala Lys Leu Lys Glu Gln Leu Arg Asn Ser Pro Ile 
                485                 490                 495     


Ile Leu Thr Tyr His Gly Leu Ser Phe Thr Asn Glu Arg Lys Pro Arg 
            500                 505                 510         


Ala Ala Asp Arg Phe Thr Glu Phe Ala Val Lys Tyr Leu Ile Asp His 
        515                 520                 525             


Gly Val Val Pro Glu Trp Leu Trp Gly Ile Glu His Phe Glu Pro Val 
    530                 535                 540                 


Thr Glu Glu Lys Leu Asp Arg Arg Ser Gly Ala Thr Met Lys Arg Glu 
545                 550                 555                 560 


Val Leu Lys Arg Lys Ile Thr Tyr His Asp His Val Pro Glu Lys Asp 
                565                 570                 575     


Glu Lys Asp Ile Gly Ile Leu Asn Pro Glu Leu Ser Ser Glu Pro Arg 
            580                 585                 590         


Leu Ala Ile Ser Asp Ser His Ala Leu Val Lys His Arg Gln Asp Asp 
        595                 600                 605             


Arg Ile Leu Phe Arg Ile Gly His Arg Ala Leu Lys Asn Ile Leu Ile 
    610                 615                 620                 


Ala His Gln Gln Gly Lys Pro Val Arg Asn Leu Leu Pro Arg Leu Ile 
625                 630                 635                 640 


Glu Asp Leu Gln Leu Val Asn Gly Ala Arg Arg Asn Gly Thr Thr Leu 
                645                 650                 655     


Asn Leu Ser Thr Leu Lys Leu Phe Asp Lys Asn Ser Leu Ala Glu Ala 
            660                 665                 670         


Thr Arg Asn Ala Ile Ala Pro Ile Ala Ala Glu Ser Ile Gln Arg Thr 
        675                 680                 685             


Ala Ala Leu Ala Lys Ala Leu His Gly Asn Thr Asp Arg Met Gly Gln 
    690                 695                 700                 


Arg Thr Pro Gly Arg Ile Ala Ser Leu Ile Thr Glu Leu Glu Arg Phe 
705                 710                 715                 720 


Gly Val Pro Asp Ser Glu Met Pro Arg Met Ser Arg Asp Ser Lys Asn 
                725                 730                 735     


Arg Gln Ile Met Arg Cys Tyr Lys Tyr Phe Asp Trp Lys Tyr Leu Asn 
            740                 745                 750         


Asp Ala Gln Tyr Lys Phe Leu Arg Gln His Glu Tyr Gln Asn Met Ser 
        755                 760                 765             


Ile Tyr His Tyr Met Leu Trp Asp Ile Arg Lys Asp Arg Gly Leu Ala 
    770                 775                 780                 


His Gly Lys Tyr Gly Asp Leu Leu Lys Gly Ile Thr Pro His Met Pro 
785                 790                 795                 800 


Pro Thr Val Gln Gln Leu Leu Phe Lys Ser Arg Asp Leu Asn Asp Leu 
                805                 810                 815     


Leu Arg Asn Thr Ala Thr Ala Thr Ile Val Leu Leu Asn Ser Trp Lys 
            820                 825                 830         


Glu Glu Leu Leu Lys Pro Ser Ile Asp Asp Glu Arg Leu Asn Ala Ile 
        835                 840                 845             


Met Ser Arg Leu Gly Val Pro Val Ser Glu Ala Asn Arg Val Phe Asn 
    850                 855                 860                 


Gln His Leu Pro Ile Ala Ile His Pro Met Leu Pro Val Arg Ala Tyr 
865                 870                 875                 880 


Tyr Ser Ala Gln Asp Ile Ser Lys Leu Ser Leu Ser Arg Ser Ile Trp 
                885                 890                 895     


Lys Asn Lys Glu Glu Arg Gln Pro Leu Val Asp Glu His Tyr Ala Tyr 
            900                 905                 910         


Glu Asp Tyr Leu Ala Gln Tyr Ala Phe Val Pro Glu Arg Lys Pro Leu 
        915                 920                 925             


Arg Lys Arg Val Ile Gly Gln Met Asn Glu Leu Ile Thr Glu Asp Ala 
    930                 935                 940                 


Leu Leu Trp Lys Cys Ala Met Thr Tyr Leu Asn Asn Ala Ser Val Val 
945                 950                 955                 960 


Val Arg Asp Val Ile Lys Gln Ala Leu Val Arg Gly Asp Gln Ala Met 
                965                 970                 975     


Lys Val Gly Ser Leu Phe Asp Ala Thr Ile Ser Ile Pro Leu Gln Pro 
            980                 985                 990         


Leu Glu Val Lys Asn Gln Gly Leu  Arg Lys Leu Leu Gln  Glu Glu Phe 
        995                 1000                 1005             


Asp Ser  Leu Lys Ile Ala Ala  Ile Glu Val Asp Leu  Lys Phe Lys 
    1010                 1015                 1020             


Gln Leu  Asp Asp Tyr Leu Phe  Met Glu Ser Arg Pro  Gln Leu Leu 
    1025                 1030                 1035             


Lys Ala  Ala Cys Gln Val Val  Arg Arg Phe Val Ala  Ser Gly Lys 
    1040                 1045                 1050             


Pro Asp  Glu Val Asn Val Val  Glu Glu Asn Gly Arg  Lys Lys Tyr 
    1055                 1060                 1065             


Ser Met  Pro Tyr Gly Val Ile  Tyr Gln Glu Ile Gln  Arg Ile Gln 
    1070                 1075                 1080             


Asn Gln  Ala Val Ser Trp Ala  Gly Thr Leu Leu Ala  Asn Glu Glu 
    1085                 1090                 1095             


Arg Val  Val Arg Ala Met Thr  Thr Glu Glu Arg Asp  Ser Phe Gly 
    1100                 1105                 1110             


Ala Gly  His Val Lys Asp Asp  Ser Gln Phe Ala Tyr  Ile Gly Phe 
    1115                 1120                 1125             


Ala Asp  Val Cys Val Lys Leu  Gly Leu Ser Pro Ser  Leu Thr Thr 
    1130                 1135                 1140             


Met Val  Arg Ser Ile Arg Asn  Thr Thr Leu His Ala  Asp Leu Pro 
    1145                 1150                 1155             


Met Gly  Trp Thr Tyr Glu Glu  Tyr Glu Lys Asp Pro  Val Leu Phe 
    1160                 1165                 1170             


Ala Val  Leu Gly His Val Pro  Lys Gln Pro Arg Ala  Pro Lys Pro 
    1175                 1180                 1185             


Ser Glu  Val Gln Ala Glu Glu  Gly Lys 
    1190                 1195         


<210>  2533
<211>  1025
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2533

Met Lys His Phe Pro Phe Leu Glu Ala Ala Ala Tyr Glu Met Thr Asn 
1               5                   10                  15      


Ser Lys Ser Pro Asn Asn Lys Glu Gln Arg Glu Lys Glu Gln Ser Glu 
            20                  25                  30          


Ala Leu Ser Leu Asn Asn Leu Lys Asn Val Leu Phe Ile Phe Leu Glu 
        35                  40                  45              


Lys Leu Gln Val Leu Arg Asn Tyr Tyr Ser His Tyr Lys Tyr Ser Glu 
    50                  55                  60                  


Glu Ser Pro Lys Pro Ile Phe Glu Thr Ser Leu Leu Lys Asn Met Tyr 
65                  70                  75                  80  


Lys Val Phe Asp Ala Asn Val Arg Leu Val Lys Arg Asp Tyr Met His 
                85                  90                  95      


His Glu Asn Ile Asp Met Gln Arg Asp Phe Thr His Leu Asn Arg Lys 
            100                 105                 110         


Lys Gln Val Gly Arg Thr Lys Asn Ile Ile Asp Ser Pro Asn Phe His 
        115                 120                 125             


Tyr His Phe Ala Asp Lys Glu Gly Asn Met Thr Ile Ala Gly Leu Leu 
    130                 135                 140                 


Phe Phe Val Ser Leu Phe Leu Asp Lys Lys Asp Ala Ile Trp Met Gln 
145                 150                 155                 160 


Lys Lys Leu Lys Gly Phe Lys Asp Gly Arg Asn Leu Arg Glu Gln Met 
                165                 170                 175     


Thr Asn Glu Val Phe Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys 
            180                 185                 190         


Leu Glu Asn Val Gln Thr Lys Asp Trp Met Gln Leu Asp Met Leu Asn 
        195                 200                 205             


Glu Leu Val Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Arg Glu Lys 
    210                 215                 220                 


Asp Arg Glu Ser Phe Lys Val Pro Phe Asp Ile Phe Ser Asp Asp Tyr 
225                 230                 235                 240 


Asp Ala Glu Glu Glu Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp 
                245                 250                 255     


Arg Phe Pro Tyr Phe Val Leu Arg Phe Phe Asp Leu Asn Glu Ile Phe 
            260                 265                 270         


Glu Gln Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile 
        275                 280                 285             


Tyr Asn Lys Leu Ile Gly Asp Glu Asp Glu Val Arg His Leu Thr His 
    290                 295                 300                 


His Leu Tyr Gly Phe Ala Arg Ile Gln Asp Phe Ala Pro Gln Asn Gln 
305                 310                 315                 320 


Pro Glu Glu Trp Arg Lys Leu Val Lys Asp Leu Asp His Phe Glu Thr 
                325                 330                 335     


Ser Gln Lys Pro Tyr Ile Ser Lys Thr Ala Pro His Tyr His Leu Glu 
            340                 345                 350         


Asn Glu Lys Ile Gly Ile Lys Phe Cys Ser Thr His Asn Asn Leu Phe 
        355                 360                 365             


Pro Ser Leu Lys Arg Glu Lys Thr Cys Asn Gly Arg Ser Lys Phe Asn 
    370                 375                 380                 


Leu Gly Thr Gln Phe Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu 
385                 390                 395                 400 


Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Thr Lys Asp His Pro Lys 
                405                 410                 415     


Gly Glu Gly Ile Asn Lys Ile Glu Lys Ile Ile Arg Thr Glu Ile Ser 
            420                 425                 430         


Asn Ile Tyr Ala Ile Tyr Asp Ala Phe Ala Asn Gly Glu Ile Asn Ser 
        435                 440                 445             


Ile Ala Asp Leu Thr Cys Arg Leu Gln Lys Thr Asn Ile Leu Gln Gly 
    450                 455                 460                 


His Leu Pro Lys Gln Met Ile Ser Ile Leu Gly Gly Arg Gln Lys Asp 
465                 470                 475                 480 


Met Glu Lys Glu Ala Glu Arg Lys Ile Gly Glu Met Ile Asp Asp Thr 
                485                 490                 495     


Gln Arg Arg Leu Asp Leu Leu Cys Lys Gln Thr Asn Gln Lys Ile Arg 
            500                 505                 510         


Ile Gly Lys Arg Asn Ala Gly Leu Leu Lys Ser Gly Lys Ile Ala Asp 
        515                 520                 525             


Trp Leu Val Ser Asp Met Met Arg Phe Gln Pro Val Gln Lys Asp Thr 
    530                 535                 540                 


Asn Asn Ala Pro Ile Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg 
545                 550                 555                 560 


Met Leu Gln His Ala Leu Ala Leu Phe Gly Ser Glu Ser Ser Arg Leu 
                565                 570                 575     


Lys Ala Tyr Phe Arg Gln Met Asn Leu Val Gly Asn Ala Asn Pro His 
            580                 585                 590         


Pro Phe Leu Ala Glu Thr Gln Trp Glu His Gln Thr Asn Ile Leu Ser 
        595                 600                 605             


Phe Tyr Arg Asn Tyr Leu Glu Ala Arg Lys Lys Tyr Leu Lys Gly Leu 
    610                 615                 620                 


Lys Pro Gln Asn Trp Lys Gln Tyr Gln His Phe Leu Ile Leu Lys Val 
625                 630                 635                 640 


Gln Lys Thr Asn Arg Asn Thr Leu Val Thr Gly Trp Lys Asn Ser Phe 
                645                 650                 655     


Asn Leu Pro Arg Gly Ile Phe Thr Gln Pro Ile Arg Glu Trp Phe Glu 
            660                 665                 670         


Lys His Asn Asn Ser Lys Arg Ile Tyr Asp Gln Ile Leu Ser Phe Asp 
        675                 680                 685             


Arg Val Gly Phe Val Ala Lys Ala Ile Pro Leu Tyr Phe Ala Glu Glu 
    690                 695                 700                 


Tyr Lys Asp Asn Val Gln Pro Phe Tyr Asp Tyr Pro Phe Asn Ile Gly 
705                 710                 715                 720 


Asn Lys Leu Lys Pro Gln Lys Gly Gln Phe Leu Asp Lys Lys Glu Arg 
                725                 730                 735     


Val Glu Leu Trp Gln Lys Asn Lys Glu Leu Phe Lys Asn Tyr Pro Ser 
            740                 745                 750         


Glu Lys Lys Lys Thr Asp Leu Ala Tyr Leu Asp Phe Leu Ser Trp Lys 
        755                 760                 765             


Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys Asn Gln Asp Ile Val Thr 
    770                 775                 780                 


Trp Leu Met Phe Lys Glu Leu Phe Asn Met Ala Thr Val Glu Gly Leu 
785                 790                 795                 800 


Lys Ile Gly Glu Ile His Leu Arg Asp Ile Asp Thr Asn Thr Ala Lys 
                805                 810                 815     


Ala Glu Ser Asn Asn Ile Leu Asn Arg Ile Met Pro Met Lys Leu Pro 
            820                 825                 830         


Val Lys Thr Tyr Glu Ile Asn Asn Lys Gly Lys Met Glu Met Glu Lys 
        835                 840                 845             


Pro Leu Ala Thr Phe Tyr Ile Glu Glu Thr Glu Thr Lys Val Leu Lys 
    850                 855                 860                 


Gln Gly Asn Phe Lys Ala Leu Val Lys Asp Arg Arg Leu Asn Gly Leu 
865                 870                 875                 880 


Phe Ser Phe Ala Glu Thr Thr Asp Leu Asn Leu Glu Glu His Pro Ile 
                885                 890                 895     


Ser Lys Leu Ser Val Asp His Glu Leu Ile Lys Tyr Gln Thr Thr Arg 
            900                 905                 910         


Val Arg Ile Phe Glu Met Val Leu Arg Leu Glu Lys Lys Leu Ile Asn 
        915                 920                 925             


Lys Tyr Pro Thr Leu Pro Thr Tyr Ser Phe Lys Asn Met Leu Glu Ser 
    930                 935                 940                 


Trp Leu Glu Asp Lys Thr Asn Ser Ala Glu Leu Asn Asn Tyr Val Asp 
945                 950                 955                 960 


Cys Leu Ile Ala Val Arg Asn Ala Phe Ala His Asn Gln Tyr Pro Met 
                965                 970                 975     


Tyr Asn Pro Lys Leu Phe Ala Glu Val Lys Lys Phe Ser Leu Phe Pro 
            980                 985                 990         


Ser Ser Asn Thr Lys Lys Thr Glu  Leu Asn Ile Ala Pro  Gln Leu Leu 
        995                 1000                 1005             


Glu Ile  Val Gly Lys Ala Ile  Lys Glu Ile Glu Lys  Ser Glu Asn 
    1010                 1015                 1020             


Lys Asn  
    1025 


<210>  2534
<211>  1162
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2534

Met Glu Glu Asn Ile Asn Lys Lys Asn Asp Ala Asn Pro Phe Gly Leu 
1               5                   10                  15      


Phe Phe Asn Glu Lys Ala Tyr Ile Gly Ser His Ala Met Lys Ala Glu 
            20                  25                  30          


Ile Asn Phe Leu Ser Asn Asn Asn Thr Phe Lys Ile Ser Gly Ala Asn 
        35                  40                  45              


Asp Val Glu Asn Asp Asn Arg Arg Ile Ser Arg Met Tyr Tyr Phe Ser 
    50                  55                  60                  


Ile Arg His Ala Phe Lys Asn Ile Asp Thr Lys Lys Val Phe Lys Tyr 
65                  70                  75                  80  


Glu Ile Glu Asn Ser Gln His Lys Met Ala Pro Thr Arg Phe Lys Asn 
                85                  90                  95      


Leu Gln Pro Gly Cys Phe Asn Lys Asp Leu Ile Glu Ile Leu Ser Lys 
            100                 105                 110         


Leu Ile His Ser Ile Arg Asn Ile Cys Ser His Tyr Ala His Val Phe 
        115                 120                 125             


Asn Glu Ile Asn Met Asp Lys Asp Gly Asn Leu Lys Glu Lys Phe Ile 
    130                 135                 140                 


Pro Phe Leu Lys Asp Ala Phe Glu Leu Ala Val Met Gln Ala Cys Gly 
145                 150                 155                 160 


Asp Glu Ser Gly Glu Ala Ser Asp Glu Gln Ile Val Asp Phe Leu Arg 
                165                 170                 175     


Ile Asn Phe Leu Phe Asn Thr Asp Leu Gln Met Thr Lys Ser Gln Ala 
            180                 185                 190         


Ile Glu Arg Thr Leu Phe Ile Asn Val Asp Glu Thr Tyr Pro Thr Phe 
        195                 200                 205             


Val Gly Tyr Gly Asp Lys Arg His Glu Leu Met Lys Ile Glu Lys Gly 
    210                 215                 220                 


Lys Tyr Leu Ser Phe Tyr Ala Cys Leu Phe Leu Leu Thr Met Phe Leu 
225                 230                 235                 240 


Tyr Arg Asp Glu Ala Val Ser Met Ile Ser Gly Ile Arg Gly Phe Lys 
                245                 250                 255     


Lys Asn Ser Asp Ser Phe Ser Ala Lys Arg Asn Val Tyr Thr Phe Phe 
            260                 265                 270         


Ala Lys Lys Pro Ser Ser Arg Asp Val Asp Asn Glu Glu Thr Pro Leu 
        275                 280                 285             


Val Lys Phe Arg Asp Ile Ile Gln Tyr Leu Ser His Tyr Pro Thr Ala 
    290                 295                 300                 


Trp Asn Asp Val Leu Leu Asn Asn Pro Asp Asp Gln Arg Ala Lys Asp 
305                 310                 315                 320 


Leu Leu Asn Lys Ile Val Glu Met Glu Ile Lys Arg Ile Phe Pro Glu 
                325                 330                 335     


Met Phe Lys Glu Glu Lys Glu Asn Ala His Phe Met Ile Tyr Ala Lys 
            340                 345                 350         


Asn Glu Ile Phe Ser Ser Leu Tyr Ser Glu Ser Leu Ala Asn Glu Tyr 
        355                 360                 365             


Ile Lys Ala Gly Leu Thr Ser Glu Glu Glu Asp Lys Phe Ser Ala Thr 
    370                 375                 380                 


Ile Glu Arg Ser His Glu Leu Thr Gly Glu Arg Lys Lys Leu Asn Asp 
385                 390                 395                 400 


Leu Leu Asn Ala Lys Asp Cys Gln Ser Lys Lys Pro Asp Ile Lys Arg 
                405                 410                 415     


Lys Glu Asn Ile Arg Gln Cys Arg Gln Arg Ile Asn Glu Leu Glu Asn 
            420                 425                 430         


Asn Gly Asn Asn Ala Glu Met Glu Lys Ile Glu Lys Arg Ile Asn Asp 
        435                 440                 445             


Asn Leu Phe Ile Gln Ser Tyr Gly Arg Asn Lys Asp Arg Phe Met Gln 
    450                 455                 460                 


Phe Ala Val Trp Tyr Leu Ala Glu Thr Asn Tyr Phe Gly Gly Asn Ala 
465                 470                 475                 480 


Met Tyr Glu Ile Tyr Gln Phe Asn Thr Ser Asp Glu Gln His Thr Tyr 
                485                 490                 495     


Leu Lys Ser Ala Lys Thr Lys Val Ser Asn Gly Asp Met Thr Lys Lys 
            500                 505                 510         


Glu Tyr Asp Ala Leu Arg Val Ser His Gly Arg Ile Val Thr Tyr Val 
        515                 520                 525             


Thr Tyr Lys Glu Ile Ala Asn Lys Tyr Ser Leu Leu Asp Asp Pro Phe 
    530                 535                 540                 


Val Tyr Glu Asn Asn Ala Ile Gln Val Tyr Leu Pro Lys Asp Gly Asn 
545                 550                 555                 560 


Asn Tyr Asn Tyr Lys Ser Lys Ser Glu Leu Asn Asp Asn Gly Thr Phe 
                565                 570                 575     


Tyr Ile Ile Gln Arg Ser Leu Ile Val Tyr Leu Leu Glu His Cys Leu 
            580                 585                 590         


Tyr Ser Asn Ile Pro Phe Lys Tyr Ile Ile Lys Asn Tyr Lys Lys Ser 
        595                 600                 605             


Arg Asp Lys Lys Leu Asn Glu Tyr Lys Ala Thr Leu Ser Ser Glu Asn 
    610                 615                 620                 


Val Ser Ile Thr Ala Glu Gln Ser Arg Glu Met Ser Lys Leu Leu Pro 
625                 630                 635                 640 


Lys Arg Leu Leu His His Tyr Met Pro Asp Thr Ala Glu Thr Thr Ser 
                645                 650                 655     


Asn Gly Ser Ala Leu Phe Asn Ile Leu Asn Val Ala Asn Glu His Glu 
            660                 665                 670         


Lys Arg Tyr Asn Leu Leu His Glu Gln Ala Lys Lys Asn Asn Thr Ser 
        675                 680                 685             


Ala Asp Phe Asp Lys Lys Asn Lys Gly Lys Gln Phe Lys Leu Asn Phe 
    690                 695                 700                 


Val Trp Lys Ala Trp Asn Arg Met Tyr Phe Ala Asp Met Phe Arg Lys 
705                 710                 715                 720 


Gln Val Ala Asp Ser Ser Asp Gly Lys Asn His Lys Arg Phe Asn Val 
                725                 730                 735     


Thr Arg Asp Glu Phe Asn Asp Phe Ser Arg Trp Met Tyr Ala Phe Asp 
            740                 745                 750         


Glu Val Pro Gln Tyr Lys Glu Tyr Leu Arg Arg Leu Phe Ala Pro Lys 
        755                 760                 765             


Leu Phe Phe Glu Ile Lys Lys Phe Lys Asp Leu Phe Glu Lys Gly Asn 
    770                 775                 780                 


Ser Leu Asn Asp Tyr Tyr Ala Ser Thr Lys Glu Leu Tyr Lys Lys Trp 
785                 790                 795                 800 


Ala Asp Asn Gln Leu Lys Asn Ser Gln Lys Glu Arg Tyr Thr Trp Ser 
                805                 810                 815     


Lys Tyr Asp Asp Asn Ile Ile Asn Gly Ser Thr Val Cys Ile Asn Leu 
            820                 825                 830         


His Thr Phe Ile Asn Lys Met Lys Glu Met Lys Leu Ile Asn Cys Tyr 
        835                 840                 845             


Asn Asp His Ile Gln Tyr Glu Ser Cys Arg Asn Ala Gln Asn Leu Val 
    850                 855                 860                 


Asp Phe Tyr Tyr Leu Ser Ser Leu Phe Asn Lys Glu Tyr Arg Glu Lys 
865                 870                 875                 880 


His Asp Lys Thr Lys Ser Ala Ala Tyr Lys Lys Leu Tyr Asn Ser Leu 
                885                 890                 895     


Asn Thr Ser Arg Leu Glu Asp Thr Leu Leu Tyr Glu Ile Ala Met Gln 
            900                 905                 910         


Tyr Leu Lys Ser Val Asn Pro Gly Thr Asn Ile Asp Asp Leu Lys Arg 
        915                 920                 925             


Pro Val Val Asp Phe Phe Asn Ser Asp Ile Cys Phe Gly Ile Tyr Asp 
    930                 935                 940                 


Ser Asn Asn Thr Ser Gly Lys His Leu Tyr Asn Val Ala Ile Pro Phe 
945                 950                 955                 960 


Asn Lys Ile Glu Ala Phe Gly Gln Leu Leu Val Leu Asn Lys Lys Ser 
                965                 970                 975     


Glu Tyr Leu Gln Arg Pro Ile Ile Thr Gln Leu Lys Glu Tyr Leu Ser 
            980                 985                 990         


Asp Glu Lys Tyr Ser Ser Ala Phe  Asp Thr Asp Glu Leu  Lys Ala Ile 
        995                 1000                 1005             


Arg Asp  Ser Phe Ile Asn Val  Lys Ala Asp Glu Tyr  Pro Thr Ile 
    1010                 1015                 1020             


Arg Tyr  Asn Asp Met Phe Lys  Val Ile Lys Ser Leu  Lys Asp Asp 
    1025                 1030                 1035             


Ala Leu  Gln Met Ser Arg Leu  Thr Leu Leu Ile Glu  Lys Tyr Ala 
    1040                 1045                 1050             


Ile Ala  Asn Asp Arg Asp Lys  Lys Ile Ser Glu Lys  Glu Asn Glu 
    1055                 1060                 1065             


Ile Asp  Phe Asp Pro Ser Ile  Leu Phe Asp Ser Asp  Asn Asn Phe 
    1070                 1075                 1080             


Lys Asp  Met Arg Asp Ser Ala  Leu His Phe Asn Ile  Pro Pro Val 
    1085                 1090                 1095             


Pro Tyr  Lys Asp Tyr Ile Arg  Leu Met Glu Met Ala  Phe Ile Asn 
    1100                 1105                 1110             


Lys Trp  Ile Lys Ser Asp His  Pro Thr Ser Trp Asn  Ser Leu Asn 
    1115                 1120                 1125             


Ser Ser  Gln Gln Glu Ile Cys  Asn Val Phe Met Lys  Cys Leu Tyr 
    1130                 1135                 1140             


Asn Tyr  Arg Lys Thr Asp Ala  Ala Thr Tyr Tyr Ser  Lys Val Ile 
    1145                 1150                 1155             


Lys Glu  Leu Leu 
    1160         


<210>  2535
<211>  1097
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2535

Met Glu Tyr Thr Arg Tyr Lys Glu Trp Gly Lys Asp Leu Phe Tyr Phe 
1               5                   10                  15      


Asn His Phe Ala Asn Met Ala Arg His Asn Ala Phe Leu Ile Ile Asn 
            20                  25                  30          


Asp Ile Leu Asn Thr Val Tyr Lys Ala Glu Asp Gln Leu Thr Glu Glu 
        35                  40                  45              


Ser Leu Ser Asn Leu Tyr Lys Lys Val Leu Ala Lys Ser Lys Gly Arg 
    50                  55                  60                  


Pro Asp Glu Leu Ala Leu Leu Ser Ser Leu Leu Lys Lys His Phe Pro 
65                  70                  75                  80  


Phe Leu His Tyr Tyr Asp Asn Val Gln Ser Asp Glu Ile Ala Pro Tyr 
                85                  90                  95      


Leu Asn Ser Ile Lys Asp Leu Asn Ile Tyr Ser Asn Lys Pro Glu Glu 
            100                 105                 110         


Val Pro Lys Asp Asp Asp Pro Gly Met Cys Ile Trp Trp Leu Ser Tyr 
        115                 120                 125             


Val Phe Leu Pro Ile Leu Asn Arg Leu Arg Asn Glu Thr Ala His Tyr 
    130                 135                 140                 


Gly His Thr Lys Leu Gly Gly Asp Ile Pro Phe Leu Glu Gln Ser Phe 
145                 150                 155                 160 


Asn Glu Thr Ile Lys Glu Ala Gln Lys Arg Met Asn Tyr Ser His Glu 
                165                 170                 175     


Asp Val Glu His Leu Leu Arg Thr Asp Ser Tyr Tyr Lys Pro Leu Ser 
            180                 185                 190         


Ile Asn Lys Ser Leu Ser Glu Lys Gly Ile Phe Tyr Leu Tyr Cys Leu 
        195                 200                 205             


Phe Leu Asp Lys Lys Asn Gly Tyr Gln Phe Leu Ser His Ile Lys Gly 
    210                 215                 220                 


Phe Lys Asp Arg Arg Glu Thr Ala Lys Lys Ala Thr Thr Glu Val Phe 
225                 230                 235                 240 


Thr His Asn His Cys Arg Leu Pro Tyr Pro Lys Leu Asp Ser Ser Asp 
                245                 250                 255     


Leu Ala Leu Asp Ile Leu Asn Glu Leu Asn Arg Cys Pro Gly Ala Leu 
            260                 265                 270         


Tyr Ser Val Leu Ser Asp Asp Asp Arg Lys Lys Phe Val Thr Thr Leu 
        275                 280                 285             


Pro Thr Ala Glu Glu Gly Asp Glu Val Met Glu Ser Val Met Lys Arg 
    290                 295                 300                 


Gly Lys Glu Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Leu Glu Gln 
305                 310                 315                 320 


Glu Gly Val Leu Arg Gly Ile Ser Phe Gln Leu Phe Leu Gly Arg Phe 
                325                 330                 335     


Glu Gln Lys Glu Ala His His Lys Ile Val Gly Gln Glu Met Arg Glu 
            340                 345                 350         


His Lys Leu Leu Lys Asn Ile His Thr Phe Gly Gln Leu Glu Arg Phe 
        355                 360                 365             


Lys Thr Glu Ala Ala Asn Asn Phe Phe Leu Asn Glu Lys Lys Gly Ile 
    370                 375                 380                 


Val Glu Phe Tyr Ala Pro Ala Tyr Arg Met Val Gly Asn Arg Ile Gly 
385                 390                 395                 400 


Leu Ile Leu Lys Asp Ala Asn Ile Asn Asp Thr Gly Phe Glu Glu Val 
                405                 410                 415     


Leu Asp Asn Tyr Lys Leu Pro Leu Glu Glu Arg Asn Cys Pro Asp Ala 
            420                 425                 430         


Ile Met Ser Thr His Glu Leu Thr Ala Leu Phe Phe Tyr Asn Tyr Leu 
        435                 440                 445             


His Arg Glu Gly Ile Ile Arg Thr Ser Pro Lys Glu His Ile Leu Ser 
    450                 455                 460                 


Phe Leu Gln Asn Phe Lys Arg Phe Arg Glu Asp Leu Lys Lys Gly Lys 
465                 470                 475                 480 


Leu Lys Pro Ile Pro Gly Glu His Lys Leu Tyr Lys Met Lys Cys His 
                485                 490                 495     


Lys Gln Gly Ser Ser Asn Glu Leu Asn Arg Lys Arg Ile Leu Leu Gln 
            500                 505                 510         


Glu Ile Leu Asn Glu Tyr Gly Leu Lys Val Ala Trp Leu Pro Asp Ala 
        515                 520                 525             


Cys Arg Glu Tyr Leu Leu Gly Tyr Thr Ser Ser Asp Asn Thr His Ile 
    530                 535                 540                 


Ile Lys Gln Glu Phe Leu Lys Met Leu Asn Ser Ser Lys Ser Arg Arg 
545                 550                 555                 560 


Asp Lys Ile Ile Ala Phe Asn Lys Ser Ile Ser Glu Tyr Lys Lys Arg 
                565                 570                 575     


Asn Glu Ile Lys Leu Thr Gln Ala Lys Leu Glu Ile Arg Thr Gly Glu 
            580                 585                 590         


Leu Ala Thr Gln Leu Ala Arg Asp Ile Ile Tyr Met Thr Ser Pro Met 
        595                 600                 605             


Asn Lys Glu Gly Lys Ser Lys Lys Met Asn Asp Leu Glu Tyr Asn Val 
    610                 615                 620                 


Leu Gln Ser Met Leu Ala Tyr Phe Pro Leu His Lys Asn Glu Leu Thr 
625                 630                 635                 640 


Ala Tyr Leu Gly Ile Leu Lys Glu Gly Lys Val Trp Lys His Pro Phe 
                645                 650                 655     


Leu Glu Asp Val Leu Lys Glu Leu His Ser Ala Gln Ser Leu Ala Asp 
            660                 665                 670         


Phe Tyr Ser Leu Tyr Tyr Asp Ala Lys Ile Asp Trp Ile Asn His Lys 
        675                 680                 685             


Ile Ile Lys Glu Gln Val Glu His Asp Asn Asn Lys Lys Lys Tyr Ser 
    690                 695                 700                 


Trp Thr Leu Arg Val Gly Ala Glu Lys Met Val Thr Glu Gln Tyr Ala 
705                 710                 715                 720 


Tyr Leu Leu Asn Leu Glu Lys Lys Thr Lys Thr Ala Pro Gln Lys Glu 
                725                 730                 735     


Tyr Ala Asp Lys Ala Val Phe Leu Pro Thr Gly Leu Phe Asp Glu Ala 
            740                 745                 750         


Ile Ser Lys Ser Leu Ile Asp Lys Gly Tyr Glu Leu Arg Glu Asn Ser 
        755                 760                 765             


Asn Thr Ala Gly Cys Leu Lys Val Tyr Leu Asn Lys Glu Thr Gln Pro 
    770                 775                 780                 


Met Tyr Ser Glu Leu Lys Arg Tyr Tyr Arg Tyr Val Thr Gly Arg Gly 
785                 790                 795                 800 


Pro Arg Leu Thr Gly Arg Met Met Glu Arg Glu Glu Ala Lys Asn Phe 
                805                 810                 815     


Leu Ser His Asn Phe Ala Asn Ser Ser Leu Gln Pro Met Lys Lys Glu 
            820                 825                 830         


Ser Leu Lys Gln Phe Gly Lys Lys Ile Lys Glu Lys Glu Ala Glu Ile 
        835                 840                 845             


Leu Arg Gln Gln Asn Asn Asp Arg Ala Leu Phe Leu Met Leu Tyr Ala 
    850                 855                 860                 


Met Pro Asp Ala Asn Gly Val Ser Arg Ile Val Lys Glu Lys Thr Gly 
865                 870                 875                 880 


Leu Cys Lys Leu Gly Phe Asp Leu Asn Asp Asn Leu Leu Asn Thr Glu 
                885                 890                 895     


Tyr Thr Val Lys Gln Thr Leu Val Arg Met Val Asn Asn Val Arg Val 
            900                 905                 910         


Glu Arg Val Val Thr Ala Thr Leu Pro Val Lys Arg Tyr Gly Glu Met 
        915                 920                 925             


Arg Arg Phe Leu Lys Asp Arg Arg Ile Asp Gly Leu Leu Leu Tyr Tyr 
    930                 935                 940                 


Pro Glu Gly Lys Glu Ile Pro Leu Gly Thr Leu Glu Ser Ser Lys Thr 
945                 950                 955                 960 


Ala Leu Lys Gly Glu Lys Tyr Ser Tyr Ser Asn Leu Ile Asp Glu Leu 
                965                 970                 975     


Asp Val Tyr Asp Arg Lys Arg Asn Glu Leu Met Glu Arg Ile Tyr Glu 
            980                 985                 990         


Val Asp Arg Leu Met Ala Val Asn  Phe Pro Leu Ile Lys  Lys Lys Thr 
        995                 1000                 1005             


Lys Gly  Asn Ala Ser Tyr Tyr  Glu His Tyr Asp Cys  Leu Asp Tyr 
    1010                 1015                 1020             


Ala Arg  Thr Asn Leu Gly Leu  Ala Asn Gln Val Ser  Leu Leu Gln 
    1025                 1030                 1035             


Arg Glu  Arg Ile Thr Leu Leu  Arg Ser Lys Leu Ala  His Asn Gln 
    1040                 1045                 1050             


Ile Pro  Tyr Glu Ala Trp Ile  Cys Glu Glu Ile Glu  Lys Met Asp 
    1055                 1060                 1065             


Asp Pro  Leu Ile Thr Ser Arg  Ile Ile Asn Leu Val  Ala Ser Cys 
    1070                 1075                 1080             


Tyr Glu  Glu Leu Leu Leu Ser  Ile Lys Lys Lys Ile  Lys Glu 
    1085                 1090                 1095         


<210>  2536
<211>  1242
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2536

Met Glu Gln Asn Arg Lys Glu Gly Ser Leu Arg Thr Gln Glu Asp Ile 
1               5                   10                  15      


Gln Tyr Phe Gly Ser Tyr Phe Asn Met Ala Arg His Asn Leu Tyr Leu 
            20                  25                  30          


Ile Thr Asn His Leu Thr Ser Val Phe Ser His Leu Asn Phe Ser Gln 
        35                  40                  45              


Leu Asp Asp Asp Glu Asp Ile Trp Ser Asp Lys Pro Glu Val Asn Glu 
    50                  55                  60                  


Lys Asn Ile Leu Leu Asn Ile Phe Asp Thr Lys Asn Glu Arg Leu Gln 
65                  70                  75                  80  


Asp Glu Arg Ile Arg Val Phe Arg Tyr Leu Met Arg Arg His His Leu 
                85                  90                  95      


Pro Cys Leu Arg Ile Phe Thr Asn Asp Phe Lys Val Leu Glu Thr Thr 
            100                 105                 110         


Gly Asn Thr Ile Lys Lys Asp Glu Leu Glu Val Asp Phe Asp Ala Val 
        115                 120                 125             


His Lys Phe Leu Asn Ile Ala Phe Lys Glu Ile Asn Leu Phe Arg Asn 
    130                 135                 140                 


Ser Tyr Thr His Tyr Leu Ser Ile Asn Glu Glu Gly Lys Arg Leu Lys 
145                 150                 155                 160 


Lys Lys Lys Lys Ile Ser Ser Lys Leu Val Pro Val Leu Asn Ser Leu 
                165                 170                 175     


Phe Ser Tyr Ala Pro Glu Tyr Ser Phe Leu Arg His Asn Ile Asp Lys 
            180                 185                 190         


Ala Asn Lys Asp Val Lys Ile Tyr Lys Glu Glu Val Lys Glu Tyr Tyr 
        195                 200                 205             


Asp Asn Ile Lys Ser Lys Tyr Lys Leu Phe Glu Asn Asp Ser Asn Glu 
    210                 215                 220                 


Leu Thr Asp Gln Gly Met Tyr Phe Phe Ile Thr Leu Phe Leu Glu Arg 
225                 230                 235                 240 


Ala His Gly Ile Lys Phe Leu Lys Arg Phe Arg Gly Phe Lys Asn Glu 
                245                 250                 255     


Thr Thr Pro Pro Phe Lys Ala Thr Ile Gln Ala Phe Thr Thr Tyr Thr 
            260                 265                 270         


Leu Lys Ile Pro Asp Val Arg Leu Asp Asn Asp Ile Pro Glu Gln Thr 
        275                 280                 285             


Met Ile Met Glu Val Leu Asn Glu Leu Asn Lys Cys Pro Glu Glu Leu 
    290                 295                 300                 


Phe Lys Phe Leu Lys Lys Glu Asp Lys Asp Arg Phe Gln Pro Val Ile 
305                 310                 315                 320 


Ser Asp Glu Ser Leu Thr Asn Ile Ile Asn Ser Ser Asn Tyr Glu Glu 
                325                 330                 335     


Ile Ser Asp Glu Asp Ile Asp Arg Leu Ile Lys Glu Asn Ser Val Leu 
            340                 345                 350         


Lys Arg Arg Glu Asp Arg Phe Pro Tyr Phe Ala Leu Gln Tyr Leu Glu 
        355                 360                 365             


Ile Met Ser Lys Leu Lys Asn Ile Arg Phe Gln Ile Tyr Leu Gly Lys 
    370                 375                 380                 


Leu Val Leu Lys Thr Tyr Asp Lys Glu Asn Pro Asn Ile Glu Arg Arg 
385                 390                 395                 400 


Val Ile Thr Asp Ile His Ala Phe Gly Lys Leu Ser Asp Phe Val Gly 
                405                 410                 415     


Lys Glu Ala Glu Val Leu Asp Thr Phe Asn Ser Gln Leu Lys Asp Tyr 
            420                 425                 430         


Gly Tyr Ser Val Ala Trp Asp Gln Tyr Lys Pro Ser Tyr Ala Ile Glu 
        435                 440                 445             


Met Asn Arg Ile Gly Phe Tyr Leu Phe Asn Asp Gln Gly Asp Lys Val 
    450                 455                 460                 


Glu Asn Lys Ile Leu Pro Ser Leu Cys Lys Asn Lys Asn Leu Glu Arg 
465                 470                 475                 480 


Lys Val Glu Ile Lys Val Asn Lys Ile Gln Pro Thr Gly Phe Ile Ser 
                485                 490                 495     


Thr His Met Leu Pro Lys Phe Leu Ile Ser Tyr Leu Met Gly Asp Val 
            500                 505                 510         


Asn Glu Lys Asn Gly Glu Lys Thr Ile Thr His Phe Leu Glu Lys Val 
        515                 520                 525             


Asn Val Ser Ile Leu Asp Gln Asn Ile Ile Asn Gln Ile Lys Ser Glu 
    530                 535                 540                 


Ile Gln Asn Leu Asp Pro Ile Glu Phe Thr Lys Arg Cys Pro Lys Leu 
545                 550                 555                 560 


Ser Ala Ile Lys Asn Val Lys Lys Leu Arg Val Ala Gly Ala Ile Asp 
                565                 570                 575     


Lys Lys Ile Val Glu Tyr Gln Tyr Ile Asn Asp Thr Asp Ile Ala Lys 
            580                 585                 590         


Leu Val Gln Lys Thr Gly Leu Ala Tyr Asp Thr Met Val Thr Tyr Ser 
        595                 600                 605             


Lys Asp Lys Phe Lys Glu Lys Thr Asn His Leu Asn Leu Ser Lys Lys 
    610                 615                 620                 


Glu Leu Glu Thr Phe Ala His Ile Lys Tyr Lys Tyr Tyr Leu Ser Glu 
625                 630                 635                 640 


Arg Arg Lys Ala Leu Asp Ser Val Leu Lys Ala Tyr Phe Pro Glu Ile 
                645                 650                 655     


Gly Ser Gln Asp Ile Pro Lys Glu Leu Tyr Asn Tyr Leu Leu Asn Ile 
            660                 665                 670         


Asn Glu Gln Asp Asn Lys Lys Leu Glu His Arg Arg Ile Lys Asp Glu 
        675                 680                 685             


Val Thr Lys Thr Lys Lys Leu Ile Lys Asp Val Asn Arg Ser Leu Lys 
    690                 695                 700                 


Phe Glu Asp Lys Ile Leu Leu Gly Asp Leu Ala Thr Lys Ile Ala Arg 
705                 710                 715                 720 


Asp Ile Ile Asn Met Ile Ile Asp Lys Asp Leu Lys Val Ser Met Thr 
                725                 730                 735     


Asn Pro Phe Ala Asn Arg Leu Gln Asn Leu Ile Ala Tyr Phe Ser Thr 
            740                 745                 750         


Asn Lys Glu Ala Ile Val Ala Leu Cys Glu Ser Tyr Lys Val Phe Glu 
        755                 760                 765             


His Asn Lys Gly His Phe Phe Leu Thr Arg Glu Leu Ile Leu Asn Ser 
    770                 775                 780                 


Thr Gly Val Ile Asp Phe Tyr Ile Arg Tyr Phe Glu Ala Lys Ile Glu 
785                 790                 795                 800 


Lys Ile Lys Glu Val Leu Leu Val Arg Gly Lys Glu Gly Gly Tyr Glu 
                805                 810                 815     


Ile Asn Thr Glu Leu Ile Pro Tyr Ser Tyr Thr Gln Tyr Leu Pro Lys 
            820                 825                 830         


Glu Val Lys Glu Glu Asn Lys Asn Thr Cys Lys Asn Leu Phe Glu Gln 
        835                 840                 845             


Trp Leu Tyr Tyr Lys Gln Lys Ser Pro Val Asn Leu Pro Val Thr Leu 
    850                 855                 860                 


Leu Asp Glu Asp Leu Thr Ser Ala Leu Lys Ser Lys Leu Lys Leu Lys 
865                 870                 875                 880 


Pro Asp Leu Lys Asp Gly Phe Ser Lys Leu Ile Gln Leu Tyr Leu Lys 
                885                 890                 895     


Asp Asp Ala Gln Glu Phe Tyr Ser Phe Asp Arg Val Tyr Arg Asn Asn 
            900                 905                 910         


Asp Asn Glu His Val Ile Lys Tyr Ser Asn Glu Gly Ser Ser Lys Glu 
        915                 920                 925             


Met Gln Ile Lys Tyr Gly Lys Val Ala Val Glu Ser Glu Lys Ile Ile 
    930                 935                 940                 


Arg His Val Leu Leu Lys Asp Arg Ile Leu Arg Val Ile Cys Glu Asp 
945                 950                 955                 960 


Leu Leu Lys Ser Asp Lys Asn Thr Ser Ser Thr Lys Ser Phe Leu Leu 
                965                 970                 975     


Lys Asp Ile Ser Pro Trp Ser Glu Thr Asn Ile Leu Asn Lys Pro Asn 
            980                 985                 990         


Glu Phe Ser Tyr Asn Leu Arg Lys  Asn Ile Asp Gly Ser  Gly Thr Glu 
        995                 1000                 1005             


Tyr Cys  Thr Ile Val Ala Lys  Asp Ser Thr Glu Gln  Ile Arg Gln 
    1010                 1015                 1020             


Ile Asn  Glu Trp Asn Asp Leu  Ser Lys Glu Ile Lys  Ser Lys Phe 
    1025                 1030                 1035             


Leu Lys  Leu Asn Ala Glu Gln  Lys Ile Asp Phe Leu  Thr Thr Gln 
    1040                 1045                 1050             


Asp Glu  Lys Thr Lys Leu Val  Leu Leu Gly Gln Gln  Asn Tyr Gln 
    1055                 1060                 1065             


Trp Lys  Phe Ser Asp Phe Gly  Arg Phe Arg Arg Phe  Met Lys Asp 
    1070                 1075                 1080             


Lys Arg  Ile Asn Glu Met Val  Lys Tyr Phe Glu Pro  Lys Gln Ile 
    1085                 1090                 1095             


Pro Phe  Asp Leu Leu Glu Phe  Gln Ile Leu Gln Tyr  Asn Ile Tyr 
    1100                 1105                 1110             


Arg Glu  Lys Met Phe Asp Lys  Ile Phe Glu Leu Glu  Arg Val Met 
    1115                 1120                 1125             


Ser Glu  Arg Tyr Phe Glu Asp  Ile Lys Ser Lys His  Leu Glu Asn 
    1130                 1135                 1140             


Phe Lys  Tyr Asn Glu Val Gly  Phe Gln Thr Tyr Leu  Asn Val Leu 
    1145                 1150                 1155             


Ser Glu  Lys Ile Ala Ser Gly  Tyr Asp Ile Ala Ile  Leu Lys Trp 
    1160                 1165                 1170             


Gly Arg  Asn Lys Phe Ser His  Thr Glu Ile Val Tyr  Tyr Asn Phe 
    1175                 1180                 1185             


Ile Ser  Lys Ile Ala Val Gln  Asp Ile Glu Glu Phe  Glu Leu Lys 
    1190                 1195                 1200             


Lys His  Leu Glu Gly Tyr Lys  Glu Asn Val Ser Phe  Asn Ile Ala 
    1205                 1210                 1215             


Arg Asn  Ile Tyr Arg Val Phe  Ser Arg Glu Val Asp  Lys Thr Ile 
    1220                 1225                 1230             


Asn Leu  Ile Asn Asn Ser Phe  Lys Ile 
    1235                 1240         


<210>  2537
<211>  1128
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2537

Met Glu Ile Leu Thr Ile Pro Glu Val Ile Lys Cys Arg Thr Leu Ser 
1               5                   10                  15      


Asp Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Val Leu Asn Ile Ser Asn His Ile Ala Lys Glu Phe Lys Leu Pro Leu 
        35                  40                  45              


Leu Pro Glu Glu Ala His Leu Lys Asn Ser Phe Leu Cys Lys Lys Glu 
    50                  55                  60                  


Asn Lys Lys Ile Asp Trp Asn His Val Tyr Ala Arg Thr Ile Arg Phe 
65                  70                  75                  80  


Leu Ser Val Met Lys Val Phe Asp Ala Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Lys Thr Ile Asp Trp Glu Gly Lys Asp Phe Ala Ser Met Cys Asp 
            100                 105                 110         


Thr Leu Asn Ile Val Phe Ser Glu Leu Gln Glu Phe Ser Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Glu Thr Lys Arg Lys Thr Thr Val 
    130                 135                 140                 


Ser Asp Glu Leu Ala Leu Phe Leu Arg Thr Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Glu Tyr Thr Lys Val Arg Phe Lys Gly Ile Leu Asn Asp Glu Asp Tyr 
                165                 170                 175     


Gln Leu Val Val Ser Lys Lys Met Leu Glu Thr Asn His Thr Ile Thr 
            180                 185                 190         


His Glu Gly Leu Val Phe Leu Thr Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Arg Phe Ile Arg Lys Ile His Gly Leu Ser Gly Pro Lys Asp 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Cys Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro Gln Glu Gln Phe Arg Ser Asp Asn Arg Arg Gln Ala Ile Ser 
                245                 250                 255     


Leu Glu Leu Met Asn Glu Leu Lys Lys Cys Pro Lys Val Leu Tyr His 
            260                 265                 270         


Val Ile Thr Glu Glu Trp Lys Gln Lys Leu Lys Ser Val Pro Glu Glu 
        275                 280                 285             


Leu Glu Thr Lys Asn Leu His Tyr Asn Thr Lys Arg Glu Thr Lys Ile 
    290                 295                 300                 


Glu Phe Glu Asp Tyr Asp Leu Tyr Ile Glu Ser Leu Thr Lys Gln Val 
305                 310                 315                 320 


Arg Tyr Asn Asn Arg Phe Ser Glu Phe Ala Leu Lys Tyr Ile Asp Glu 
                325                 330                 335     


Thr Gly Ile Phe Ser Glu Phe Arg Phe Gln Leu Asp Leu Gly Lys Ile 
            340                 345                 350         


Leu Val Asp Glu Tyr Leu Lys Asn Phe Asn Asp Glu Arg Val Gln Arg 
        355                 360                 365             


Cys Ile Ile Glu Asn Ala Lys Ala Phe Gly Lys Leu Asn Asp Tyr Thr 
    370                 375                 380                 


Asn Glu Thr Lys Val Met Ser Leu Ile Val Asn Gly Ser Pro Leu Lys 
385                 390                 395                 400 


Ser Phe Asp Arg Phe Ala Pro His Tyr Asn Ile Glu Ser Asn Lys Ile 
                405                 410                 415     


Gly Ile Ser Thr His Glu Val Thr Ala Lys Leu Val Pro Asn Ser Lys 
            420                 425                 430         


Gly Glu Pro Ala Lys Lys Leu His Gln Pro Leu Pro Glu Ala Phe Leu 
        435                 440                 445             


Ser Leu His Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu Gln Lys 
    450                 455                 460                 


Gly Glu Pro Glu Lys Leu Ile Asn Glu Phe Ile Leu Val Asn Asn Ser 
465                 470                 475                 480 


Lys Leu Met Asn Met Ser Phe Ile Glu Glu Val Lys Asn Gln Leu Pro 
                485                 490                 495     


Lys Glu Trp Asp Lys Phe Gln Arg Arg Thr Asn Ala Lys His Glu Leu 
            500                 505                 510         


Ala Tyr Asp Glu Asn Thr Leu Ala Phe Leu Leu Gln Arg Lys Gln Ile 
        515                 520                 525             


Leu Asn Lys Thr Leu Leu Ala Tyr Gln Leu Asn Asp Lys Gln Ile Pro 
    530                 535                 540                 


Thr Arg Ile Leu Asp Tyr Trp Leu Asn Ile Ser Asp Ala Asp Glu Glu 
545                 550                 555                 560 


Arg Ala Ile Ser Asn Arg Leu Lys Ser Ile Lys Arg Asp Cys Met Ser 
                565                 570                 575     


Arg Leu Lys Ala Leu Ser Lys Phe Asn Glu Asn Gly Asn Arg Asn Lys 
            580                 585                 590         


Ile Pro Gly Ile Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile Ile 
        595                 600                 605             


Glu Met Val Val Ser Glu Gly Lys Lys Arg Lys Ile Thr Ser Phe Tyr 
    610                 615                 620                 


Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Gly Asp Pro Asp Lys 
625                 630                 635                 640 


Lys Gln Leu Phe Ile His Ile Val Thr Lys Glu Leu Lys Leu Asn Asp 
                645                 650                 655     


Pro Gly Gly His Pro Phe Leu Asp Lys Leu Asp Leu Gln Lys Ile Asn 
            660                 665                 670         


Ser Thr Thr Gly Phe Tyr Glu Ile Tyr Leu Gln Glu Lys Gly His Lys 
        675                 680                 685             


Met Val Pro Glu Asn Asn Pro Lys Thr Gly Lys Val Ile Tyr Thr Asp 
    690                 695                 700                 


His Ser Trp Met Ala Leu Thr Phe Tyr Lys Ile Glu Phe Asn Asp Lys 
705                 710                 715                 720 


Val Asp Met Leu Met Thr Val Val Lys Leu Pro Leu Lys Lys Leu Asn 
                725                 730                 735     


Ile Pro Phe Thr Leu Arg Gln Leu Ser Gly Lys Thr Asn Asn Thr Leu 
            740                 745                 750         


Lys Gln Trp Leu Asn Asn Leu Thr Gln Gly Lys Lys Arg Asn Asp Gly 
        755                 760                 765             


Lys Arg Pro Ile Asn Leu Pro Thr Asn Leu Phe Asp Glu Arg Leu Ala 
    770                 775                 780                 


Glu Leu Leu Arg Lys Asp Leu Asp Asn Lys Lys Ile Val Tyr Trp Pro 
785                 790                 795                 800 


Tyr Ala Asn Trp Asn Glu Leu Phe Lys Thr Trp Trp Ser Ser Arg Asn 
                805                 810                 815     


Asp Gly Leu Gln Ser Phe Tyr Asn Ala Glu Arg Glu Tyr Arg Ile Phe 
            820                 825                 830         


Asp Glu Lys Val Asn Phe Tyr Pro Asn Arg Lys Glu Asn Phe Ala Asp 
        835                 840                 845             


Tyr Tyr Gln His Ala Leu Lys Leu Ala Phe Gln Lys Lys Gln Ser Lys 
    850                 855                 860                 


Arg Ile Leu Glu Gln Met Tyr Asp Gln His Leu Pro Asp Ile Leu Phe 
865                 870                 875                 880 


Asp Gln Val Glu Lys Thr Phe Arg His Thr Ile Ala Glu Thr Glu Lys 
                885                 890                 895     


Glu Ile Arg Ile Leu Gln Glu Glu Asp His Ile Met Leu Leu Met Leu 
            900                 905                 910         


Glu Ser Leu Leu Asp Asp Gly Ser Lys Gln Gln Leu Lys Leu Ser Glu 
        915                 920                 925             


Ile Arg Thr His Leu Asn Arg Thr Thr Asn Ile Arg Gln Val Val Lys 
    930                 935                 940                 


Gly Lys Leu Ser Phe Asp Asp Ser Gly Glu Leu Ile Lys Asp Asn Thr 
945                 950                 955                 960 


Asn Ser Glu Ile Val Arg Thr Val Ser Val Thr Asn Gln Leu Lys Lys 
                965                 970                 975     


Phe His Leu Arg Pro Arg Phe Ile Ser Asp Ser Arg Leu Pro Glu Leu 
            980                 985                 990         


Phe Glu Tyr Phe Pro Asp Lys Glu  Ile Gln Met Glu Ser  Leu Lys Asn 
        995                 1000                 1005             


Glu Phe  Asp Thr Tyr Asn Ala  Ala Arg Gln Val Val  Leu Asn Leu 
    1010                 1015                 1020             


Ser Phe  Asn Leu Glu Lys Met  Ile Ile Glu Lys Gly  Arg Leu Asp 
    1025                 1030                 1035             


Arg Ile  Asn Gln Leu Leu Thr  Ser Ala Thr Gly Asp  Leu Leu Thr 
    1040                 1045                 1050             


Gly His  Ile Gly His Lys Thr  Tyr Leu Thr Trp Leu  Lys Asn His 
    1055                 1060                 1065             


Gly Ile  Ile Asp Asn Asp Thr  Phe Ile Phe Met Asn  Met Val Gln 
    1070                 1075                 1080             


Tyr Cys  Phe Ser His Asn Gln  Tyr Pro Gln Lys Lys  Thr Met Ala 
    1085                 1090                 1095             


Arg Leu  Ile Ser Arg Trp Asp  Gln His Arg Phe Ala  Leu Gln Ile 
    1100                 1105                 1110             


Glu Ala  Thr Tyr Ile Gln Lys  Ile Ala Gly Ile Ile  Glu Asp Leu 
    1115                 1120                 1125             


<210>  2538
<211>  1129
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2538

Met Glu Thr Asn Gln Gln Thr His Glu Asn Arg Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Asn Asn His Val Ala Thr Asp Phe Lys Arg Lys Pro 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Asp Ala Leu Leu Cys Asn Lys Thr 
    50                  55                  60                  


Ile Lys Asn Leu Asn Trp Asn His Val His Thr Arg Ala Leu Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ser Glu Ser Leu Pro Lys Asp Glu 
                85                  90                  95      


Arg Lys Asn Ser Asp Thr Glu Gly Lys Asp Phe Thr Ser Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Ser Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Asp Ser Arg Lys Leu Ile Val 
    130                 135                 140                 


Ser Pro Glu Leu Ala Asn Phe Leu Thr Ile Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Thr Tyr Thr Lys Ala Arg Met Lys Asp Val Leu Thr Asp Ala Asp Tyr 
                165                 170                 175     


Ala Leu Val Glu Asn Leu Gln Met Val Ala Thr Asp Asn Lys Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ala Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asn Gln Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Ser 
            260                 265                 270         


Ile Ile Thr Asp Lys Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Glu Asn Leu Ile Ala Asn Ser Thr Asn Asn Glu Glu Arg 
    290                 295                 300                 


Glu Arg Ile Leu Asp Glu Ile Asp Tyr Gln Asp Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg Tyr Asn Asn Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Asp Glu Lys Asn Ile Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Asn Tyr Thr Lys Gln Phe Ala Gly Glu 
        355                 360                 365             


Gln Ala Glu Arg Lys Val Leu Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asp Pro Glu Leu Ser Gln Gln Arg Ile Asp Lys Gln 
385                 390                 395                 400 


Gln Gln Thr Ala Gly Phe Glu Gln Phe Ala Pro Arg Tyr His Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Asn Ile Ala Thr Leu Thr 
            420                 425                 430         


Ala Lys Ser Lys Ala Gly Ser Lys Val Glu His Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Gln Ala Glu Glu Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Ile Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Ser Gln Leu Pro Asp Gly Trp Asn Glu Phe Asn Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asp Ser Thr Leu Arg Tyr Leu 
        515                 520                 525             


His Gln Arg Lys Thr Ile Leu Asn Thr Ile Leu Ser Lys Tyr Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Lys Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Thr Arg Leu Lys Ala Val Glu Lys His Lys Leu 
            580                 585                 590         


Asn Lys Ser Val Lys Ile Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Glu Glu Lys Lys Lys Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Thr Asn Ala Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Asn Asp Gly His Pro Phe Leu Gln Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Gln Ala Tyr Leu Ile 
        675                 680                 685             


Glu Lys Gly Asn Lys Met Val Pro Arg Leu Asn Pro Lys Thr Asn Lys 
    690                 695                 700                 


Thr Ser Lys Val Asp Glu Ser Trp Met Met Lys Gln Phe Tyr Val Lys 
705                 710                 715                 720 


Glu Trp Lys Glu Glu Ile Ala Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Ser Arg Ile Pro Phe Thr Ile Arg Gln Trp Asp Glu Lys 
            740                 745                 750         


Glu Lys Tyr Asp Leu Asn Thr Trp Leu Arg His Val Thr Val Gly Lys 
        755                 760                 765             


Asn Asn Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe Asp 
    770                 775                 780                 


Glu Ala Leu Cys Asp Leu Leu Arg Glu Gln Leu Asp Thr Lys Ile Val 
785                 790                 795                 800 


Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Ile Trp Trp 
                805                 810                 815     


Lys Thr Arg Asn Asp Asp Thr Gln Gln Phe Tyr Gln Ser Glu Arg Glu 
            820                 825                 830         


Tyr Asn Ile Tyr Asn Glu Lys Val Arg Phe Lys Ile Asp Ser Ser Ala 
        835                 840                 845             


His Phe Ala Asp Tyr Tyr Lys Asn Ala Leu Ser Arg Ala Phe Thr Arg 
    850                 855                 860                 


Leu Lys Ala Glu Arg Glu Thr Ala Arg Gln Ser Asn Lys Arg Leu Pro 
865                 870                 875                 880 


Pro Leu Glu Tyr Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile Ala 
                885                 890                 895     


Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met Ala 
            900                 905                 910         


Val Leu Met Leu Glu Arg Leu Met Asp Asn Ser Pro Asn Leu Arg Leu 
        915                 920                 925             


Ser Lys Ile Glu Thr Leu Leu Asn Asp Thr Thr Pro Ile Arg Glu Lys 
    930                 935                 940                 


Ile Ser Ala Thr Leu Ser Phe Asp Ala Ser Gly Glu Arg Ile Ser Gly 
945                 950                 955                 960 


Lys Ser Asn Pro Thr Val Thr Lys Thr Leu Val Ala Glu Arg Lys Gln 
                965                 970                 975     


Lys Asn Tyr Thr Glu Leu Arg Lys Tyr Arg Tyr Asp Arg Arg Leu Pro 
            980                 985                 990         


Glu Leu Phe Glu Tyr Val Gln Ala  Asp Glu Ile Pro Leu  Glu Trp Leu 
        995                 1000                 1005             


Leu Glu  Glu Leu Ser Ala Tyr  Asn Asn Ala Lys Gln  Gln Val Phe 
    1010                 1015                 1020             


Asp Thr  Val Phe Thr Leu Glu  Lys Lys Ile Ile Gly  Thr Asp Pro 
    1025                 1030                 1035             


Asp Gly  Leu Lys Ser Leu Phe  Thr Gly Ala Asn Gly  Glu Leu Gln 
    1040                 1045                 1050             


Thr Gly  Asn Ile Gln His Lys  Pro Tyr Val Gln Trp  Leu Thr Asn 
    1055                 1060                 1065             


Lys Gly  Leu Ile Asn Lys Glu  Glu Lys Gln Phe Ile  Asn Met Val 
    1070                 1075                 1080             


Arg Lys  Cys Phe Ser His Asn  Gln Phe Pro Gln Arg  Lys Thr Met 
    1085                 1090                 1095             


Glu Leu  Leu Ile Pro Ala Trp  Asn Glu Lys Lys Leu  Ala Leu Gln 
    1100                 1105                 1110             


Ile Ala  Thr Val Tyr Asn Gln  Leu Ile Ala Asp Leu  Thr Asn Lys 
    1115                 1120                 1125             


Ile 
    


<210>  2539
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2539

Leu Gln Lys Gln Asp Lys Leu Phe Val Asp Arg Lys Lys Asn Ala Ile 
1               5                   10                  15      


Phe Ala Phe Pro Lys Tyr Ile Thr Ile Met Glu Asn Lys Glu Lys Thr 
            20                  25                  30          


Glu Pro Ile Tyr Tyr Glu Leu Thr Asp Lys His Phe Trp Ala Ala Phe 
        35                  40                  45              


Leu Asn Leu Ala Arg His Asn Val Tyr Thr Thr Val Asn His Ile Asn 
    50                  55                  60                  


Lys Leu Leu Glu Ile Ala Glu Leu Lys Asn Asp Glu Asp Val Leu Asn 
65                  70                  75                  80  


Ile Lys Asp Ser Trp Asn Lys Gln Ala Glu Lys Leu Asp Lys Lys Val 
                85                  90                  95      


Arg Leu Arg Asn Leu Leu Met Arg His Phe Pro Phe Leu Glu Ala Ala 
            100                 105                 110         


Ala Tyr Glu Lys Thr Thr Ser Lys Asp Ser Asn Ser Lys Glu Gln Lys 
        115                 120                 125             


Glu Lys Glu Gln Ala Glu Ala Leu Ser Leu Asp Asn Leu Lys Asn Val 
    130                 135                 140                 


Leu Phe Ile Phe Leu Glu Lys Leu Gln Ser Leu Arg Asn Tyr Tyr Ser 
145                 150                 155                 160 


His Tyr Lys Tyr Ser Glu Glu Ala Gln Lys Pro Thr Phe Glu Asn Asp 
                165                 170                 175     


Leu Leu Lys Asn Met Tyr Lys Ile Phe Asp Thr Asn Val Arg Leu Val 
            180                 185                 190         


Lys Arg Asp Tyr Met His His Glu Asn Val Asp Met Gln Arg Asp Phe 
        195                 200                 205             


Ser His Leu Asn Arg Lys Lys Gln Glu Gly Gln Thr Arg Lys Ile Ile 
    210                 215                 220                 


Ala Asn Pro Asn Phe Arg Tyr His Phe Ala Asp Glu Lys Gly Asp Met 
225                 230                 235                 240 


Thr Ile Ala Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Asp Lys Lys 
                245                 250                 255     


Asp Ala Ile Trp Met Gln Lys Lys Leu Lys Gly Phe Lys Asp Gly Arg 
            260                 265                 270         


Asn Leu Arg Glu Gln Met Thr Asn Glu Val Phe Cys Arg Ser Arg Ile 
        275                 280                 285             


Ser Leu Pro Lys Leu Lys Leu Glu Asn Val Gln Thr Lys Asp Trp Met 
    290                 295                 300                 


Gln Leu Asp Met Leu Asn Glu Leu Val Arg Cys Pro Lys Ser Leu Tyr 
305                 310                 315                 320 


Glu Arg Leu Arg Glu Lys Asp Arg Glu Ser Phe Lys Val Pro Phe Asp 
                325                 330                 335     


Ile Phe Ser Asp Asp Tyr Asp Ala Glu Glu Glu Pro Phe Lys Asn Thr 
            340                 345                 350         


Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe 
        355                 360                 365             


Asp Leu Asn Glu Ile Phe Glu Gln Leu Arg Phe Gln Ile Asp Leu Gly 
    370                 375                 380                 


Thr Tyr His Phe Ser Ile Tyr Asn Lys Arg Ile Gly Asp Glu Asp Glu 
385                 390                 395                 400 


Val Arg His Leu Thr His His Leu Tyr Gly Phe Ala Arg Ile Gln Asp 
                405                 410                 415     


Phe Ala Pro Gln Asn Gln Pro Glu Glu Trp Arg Lys Leu Val Lys Asp 
            420                 425                 430         


Leu Asp His Phe Glu Thr Ser Gln Glu Pro Tyr Ile Ser Lys Thr Ala 
        435                 440                 445             


Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Lys Phe Cys Ser 
    450                 455                 460                 


Thr His Asn Asn Leu Phe Pro Ser Leu Lys Arg Glu Lys Thr Cys Asn 
465                 470                 475                 480 


Gly Arg Ser Lys Phe Asn Leu Gly Thr Gln Phe Thr Ala Glu Ala Phe 
                485                 490                 495     


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu 
            500                 505                 510         


Thr Lys Asp Tyr Ser Arg Lys Glu Ser Ala Asp Lys Val Glu Gly Ile 
        515                 520                 525             


Ile Arg Lys Glu Ile Ser Asn Ile Tyr Ala Ile Tyr Asp Ala Phe Ala 
    530                 535                 540                 


Asn Asn Glu Ile Asn Ser Ile Ala Asp Leu Thr Cys Arg Leu Gln Lys 
545                 550                 555                 560 


Thr Asn Ile Leu Gln Gly His Leu Pro Lys Gln Met Ile Ser Ile Leu 
                565                 570                 575     


Glu Gly Arg Leu Lys Asp Met Glu Lys Glu Ala Glu Arg Lys Ile Gly 
            580                 585                 590         


Glu Met Ile Asp Asp Thr Gln Arg Arg Leu Asp Leu Leu Cys Lys Gln 
        595                 600                 605             


Thr Asn Gln Lys Ile Arg Ile Gly Lys Arg Asn Ala Gly Leu Leu Lys 
    610                 615                 620                 


Ser Gly Lys Ile Ala Asp Trp Leu Val Ser Asp Met Met Arg Phe Gln 
625                 630                 635                 640 


Pro Val Gln Lys Asp Thr Asn Asn Ala Pro Ile Asn Asn Ser Lys Ala 
                645                 650                 655     


Asn Ser Thr Glu Tyr Arg Met Leu Gln His Ala Leu Ala Leu Phe Gly 
            660                 665                 670         


Ser Glu Ser Ser Arg Leu Lys Ala Tyr Phe Arg Gln Met Asn Leu Val 
        675                 680                 685             


Gly Asn Ala Asn Pro His Pro Phe Leu Ala Glu Thr Gln Trp Glu His 
    690                 695                 700                 


Gln Thr Asn Ile Leu Ser Phe Tyr Arg Asn Tyr Leu Glu Ala Arg Lys 
705                 710                 715                 720 


Lys Tyr Leu Lys Gly Leu Lys Pro Gln Asn Trp Lys Gln Tyr Gln His 
                725                 730                 735     


Phe Leu Ile Leu Lys Val Gln Lys Thr Asn Arg Asn Thr Leu Val Thr 
            740                 745                 750         


Gly Trp Lys Asn Ser Phe Asn Leu Pro Arg Gly Ile Phe Thr Gln Pro 
        755                 760                 765             


Ile Arg Glu Trp Phe Glu Lys His Asn Asn Ser Lys Arg Ile Tyr Asp 
    770                 775                 780                 


Gln Ile Leu Ser Phe Asp Arg Val Gly Phe Val Ala Lys Ala Ile Pro 
785                 790                 795                 800 


Leu Tyr Phe Ala Glu Glu Tyr Lys Asp Asn Val Gln Pro Phe Tyr Asp 
                805                 810                 815     


Tyr Pro Phe Asn Ile Gly Asn Lys Leu Lys Pro Gln Lys Gly Gln Phe 
            820                 825                 830         


Leu Asp Lys Lys Glu Arg Val Glu Leu Trp Gln Lys Asn Lys Glu Leu 
        835                 840                 845             


Phe Lys Asn Tyr Pro Ser Glu Lys Lys Lys Thr Asp Leu Ala Tyr Leu 
    850                 855                 860                 


Asp Phe Leu Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys 
865                 870                 875                 880 


Asn Gln Asp Ile Val Thr Trp Leu Met Phe Lys Glu Leu Phe Lys Thr 
                885                 890                 895     


Thr Thr Val Glu Gly Leu Lys Ile Gly Glu Ile His Leu Arg Asp Ile 
            900                 905                 910         


Asp Thr Asn Thr Ala Asn Glu Glu Ser Asn Asn Ile Leu Asn Arg Ile 
        915                 920                 925             


Met Pro Met Lys Leu Pro Val Lys Thr Tyr Glu Thr Asp Asn Lys Gly 
    930                 935                 940                 


Asn Ile Leu Lys Glu Arg Pro Leu Ala Thr Phe Tyr Ile Glu Glu Thr 
945                 950                 955                 960 


Glu Thr Lys Val Leu Lys Gln Gly Asn Phe Lys Val Leu Ala Lys Asp 
                965                 970                 975     


Arg Arg Leu Asn Gly Leu Leu Ser Phe Ala Glu Thr Thr Asp Ile Asp 
            980                 985                 990         


Leu Glu Lys Asn Pro Ile Thr Lys  Leu Ser Val Asp His  Glu Leu Ile 
        995                 1000                 1005             


Lys Tyr  Gln Thr Thr Arg Ile  Ser Ile Phe Glu Met  Thr Leu Gly 
    1010                 1015                 1020             


Leu Glu  Lys Lys Leu Ile Asp  Lys Tyr Ser Thr Leu  Pro Thr Asp 
    1025                 1030                 1035             


Ser Phe  Arg Asn Met Leu Glu  Arg Trp Leu Gln Cys  Lys Ala Asn 
    1040                 1045                 1050             


Arg Pro  Glu Leu Lys Asn Tyr  Val Asn Ser Leu Ile  Ala Val Arg 
    1055                 1060                 1065             


Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met Tyr Asp  Ala Thr Leu 
    1070                 1075                 1080             


Phe Ala  Glu Val Lys Lys Phe  Thr Leu Phe Pro Ser  Val Asp Thr 
    1085                 1090                 1095             


Lys Lys  Ile Glu Leu Asn Ile  Ala Pro Gln Leu Leu  Glu Ile Val 
    1100                 1105                 1110             


Gly Lys  Ala Ile Lys Glu Ile  Glu Lys Ser Glu Asn  Lys Asn 
    1115                 1120                 1125         


<210>  2540
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2540

Met Asn Thr His Gln Glu Glu Leu Gln Ser Trp Ile Thr Arg Lys Arg 
1               5                   10                  15      


Leu Pro Asp Thr Glu Met Lys Lys Tyr Trp Ala Ala Tyr Met Asn Leu 
            20                  25                  30          


Ala Arg Leu Asn Phe Phe Lys Thr Leu Met Phe Ile Ser Asn Ser Ile 
        35                  40                  45              


Gly Asp Leu Lys Pro Ala Lys Asp Asn Asn Gly Lys Gly Asn Thr Glu 
    50                  55                  60                  


Val Asn Met His Asn Met Gly Ile Leu Thr Ala Leu Leu Gly Pro Glu 
65                  70                  75                  80  


Asp Glu Glu Lys Ala Arg Leu Leu Ile Phe Lys His Phe Pro Phe Leu 
                85                  90                  95      


Arg Thr Phe Cys Ile Glu Lys Glu Leu Ser Leu Ser Lys Gln Arg Thr 
            100                 105                 110         


Ile Leu Ile Asp Met Ala Cys Ile Ile Gly Arg Tyr Arg Asn Met Tyr 
        115                 120                 125             


Ser His Ser Ile Phe Leu Ser Asp Asp Asn Glu Lys Val Leu Glu Ser 
    130                 135                 140                 


Glu Lys Arg Cys Ser Glu Tyr Leu Gln Ser Ile Leu Thr Val Ser Thr 
145                 150                 155                 160 


Arg Ile Ile Lys Glu Arg Tyr Arg Ser Asn Lys Asn Asp Ala Gln Arg 
                165                 170                 175     


Gly Met Ile Asp Asp Lys Ser Leu Glu Phe Ile Ser Glu Asn Lys Val 
            180                 185                 190         


Lys Phe Val Tyr Asp Glu Asn Gly Lys Arg Ile Thr Ala Pro Asn Lys 
        195                 200                 205             


Lys Tyr Tyr Leu Ser Thr Ile Asp Lys Asp Asn Thr His Leu Ser Tyr 
    210                 215                 220                 


Phe Gly Lys Leu Met Leu Thr Cys Ile Leu Leu Glu Lys Lys Tyr Ala 
225                 230                 235                 240 


Thr Ala Phe Leu Thr Gln Cys His Phe Leu Asp Ala Phe Asn Asp Ser 
                245                 250                 255     


Glu Ala Ala Pro Lys Leu Ser Glu Arg Arg Leu Met Leu Glu Val Met 
            260                 265                 270         


Thr Ala Leu Arg Ile Arg Leu Ala Glu Lys Lys Leu Ser Asn Glu Lys 
        275                 280                 285             


Ser Glu Val Gln Ile Ser Leu Asp Ile Leu Asn Glu Leu Lys Lys Cys 
    290                 295                 300                 


Pro Phe Glu Leu Tyr Glu Leu Leu Gly Ser Glu Asp Lys Arg Leu Phe 
305                 310                 315                 320 


Thr Ile Val Ala Asp Thr Gly Glu Thr Ile Leu Leu Arg Arg His Glu 
                325                 330                 335     


Asp Arg Phe Pro Gln Leu Ala Leu Ser Trp Ile Asp Ser Ser Lys Ala 
            340                 345                 350         


Phe Asp His Leu Arg Phe Gln Val Asn Ala Gly Lys Leu Arg Tyr Leu 
        355                 360                 365             


Phe Arg Asp Asn Lys His Cys Ile Asp Gly Gln Thr Arg Met Arg Val 
    370                 375                 380                 


Leu Glu Glu Pro Leu Asn Gly Tyr Arg Arg Leu Met Glu Phe Glu Glu 
385                 390                 395                 400 


Glu Arg Ile Gln Lys Gln Ser Gly Glu Ile Arg Ser Leu Trp Pro Gly 
                405                 410                 415     


Leu Asp Ile Leu Asn Lys Asp Glu Thr Pro Arg Asn Asp Ala Ser Val 
            420                 425                 430         


Leu Pro Tyr Ile Ser Asp Tyr Arg Val Arg Tyr Leu Phe Asp Gly Asp 
        435                 440                 445             


Asn Ile Gly Ile Ser Ile Gly Asp Phe Thr Pro Ser Ile Thr Lys Thr 
    450                 455                 460                 


Asp Glu Thr Lys Tyr Arg Val Thr Gly Lys Thr Ala Asp Cys Cys Leu 
465                 470                 475                 480 


Ser Lys Tyr Glu Leu Pro Gly Leu Leu Phe Tyr His Leu Leu Thr Leu 
                485                 490                 495     


Arg Tyr Gly Asp Asn Lys Arg Ser Thr Lys Asn Ala Glu Asp Ile Ile 
            500                 505                 510         


Ile Asp Ala Ile Lys Arg Tyr Lys Arg Leu Phe Ser Asp Val Lys Glu 
        515                 520                 525             


Gly Ile Leu Lys Pro Ile Lys Glu Gly Asn Ala Asn Gln Leu Gly Asn 
    530                 535                 540                 


Arg Ile Trp Asn Ser Tyr Gly Ile Asp Ile Lys Asp Ile Pro Asp Lys 
545                 550                 555                 560 


Ile Ile Asp Tyr Leu Leu Val Arg Glu Cys Asn Glu Asp Glu Lys Phe 
                565                 570                 575     


Thr Ala Trp Lys Asn Gly Leu Ile Ser Glu Met Leu Gln Ser Thr Lys 
            580                 585                 590         


Asn Arg Ile Lys Arg Phe Glu Lys Asp Ser Glu Ala Val Ile Ser Ser 
        595                 600                 605             


Asp Asn Lys Pro Gly Lys Lys Asn His Val Ser Leu Lys Pro Gly Ala 
    610                 615                 620                 


Tyr Ala Ser Phe Ile Ala Asn Asp Ile Val Phe Phe Gln Glu Cys Gly 
625                 630                 635                 640 


Ala Thr Glu Lys Met Thr Gly Leu Asn Phe Lys Val Met Gln Ser Arg 
                645                 650                 655     


Leu Ala Thr Phe Thr Lys Asp Gly Ser Thr Ser Phe Asn Ile Leu Leu 
            660                 665                 670         


Gln Thr Leu Lys Asn Ala His Leu Val Ser Asn Thr Tyr Gly Lys Gly 
        675                 680                 685             


Asp His Pro Phe Leu Tyr Arg Val Ile Lys Gln Gln Pro Ser Asp Ile 
    690                 695                 700                 


Val Gln Phe Tyr Lys Ile Tyr Leu Asn Glu Lys Val Leu Tyr Leu Gln 
705                 710                 715                 720 


Ser Asp Ile Pro Asp Asn Ala Ile Phe Leu His Gly Glu Arg Lys Arg 
                725                 730                 735     


Trp Glu Asn Arg Asn Glu Gln Tyr Tyr Arg Asp Leu Ala Glu Arg Tyr 
            740                 745                 750         


Leu Gln Arg Pro Ile Gln Leu Pro Arg Gln Leu Phe Glu Ser His Ile 
        755                 760                 765             


Arg Gln Leu Leu Leu Ser Asp Cys Ile Lys Gly Glu Arg Gly Asn Asp 
    770                 775                 780                 


Leu Lys Glu Ala Ile Asn Ser Ala Ala Ser Gln Gly Arg Cys Asn Thr 
785                 790                 795                 800 


Thr Tyr Met Ile Met Glu Tyr Phe Ala Asp Tyr Leu Cys Asp Gly Thr 
                805                 810                 815     


Gln Phe Phe Tyr Gly Leu Phe Asp Gly Asp Leu Ser His Glu Tyr Asn 
            820                 825                 830         


Tyr Arg Phe Tyr Ser Leu Ile Ser Asn Asn Ile Glu Asn Ser Lys Lys 
        835                 840                 845             


Leu Val Leu Thr Leu Lys Lys Gly Asn Asn Ser Lys Glu Ser Pro Phe 
    850                 855                 860                 


Ile Ser Ala Leu Glu Arg Gly Ile His Trp Ser Lys Arg Asn Pro Leu 
865                 870                 875                 880 


Met Lys Lys Gly Leu Lys Asn Asp Ser Ser Glu Gly Asp Phe Val His 
                885                 890                 895     


Ala Ala Lys Arg Ala Tyr Lys Glu Met Thr Glu Thr Glu Arg Met Phe 
            900                 905                 910         


Arg Arg Tyr Ala Val Gln Asp Glu Val Leu Phe Leu Ala Ala Lys Ile 
        915                 920                 925             


Thr Ile Arg Arg Ala Leu Gly Leu Ser Glu Gln Tyr Asn Cys Leu Leu 
    930                 935                 940                 


Gly Asp Ile Lys Pro Gln Gly Gly Ser Leu Leu Glu Gln Thr Ile Pro 
945                 950                 955                 960 


Ser Ile Thr Thr Lys His Thr Ile Asn Thr Gly Asn Lys Lys Gln Lys 
                965                 970                 975     


Pro Lys Gln Val Gln Ile Leu Gln Lys Asn Val Lys Leu Lys Asp Phe 
            980                 985                 990         


Gly Lys Val Phe Lys Leu Leu Asn  Asp Arg Arg Ile Phe  Asp Leu Leu 
        995                 1000                 1005             


Phe Asn  Lys Gly Asn Glu Ala  Val Ser Met Thr Asp  Leu Cys Glu 
    1010                 1015                 1020             


Glu Leu  Glu Arg Tyr Asp Arg  His Arg Val Asp Val  Phe Asp Ser 
    1025                 1030                 1035             


Val Leu  Lys Tyr Glu Ser Lys  Ile Thr Lys Gly Tyr  Thr Asn Lys 
    1040                 1045                 1050             


Glu Leu  Met Asn Glu Ser Gly  Gln Ile Asp Phe Lys  Ala Ile Gln 
    1055                 1060                 1065             


Ala Phe  Asp Lys Gln Asn Thr  Thr Ala Asp Lys Glu  Asp Leu Arg 
    1070                 1075                 1080             


Leu Ile  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Gln Tyr Asn 
    1085                 1090                 1095             


Asn Glu  Pro Ile Leu Phe Asp  Lys Asp Ile Pro Glu  Ile Ala Asp 
    1100                 1105                 1110             


Glu Ile  Ser Ile Ile Ala Lys  Asp Ile Glu Glu Asn  Thr Lys 
    1115                 1120                 1125         


<210>  2541
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2541

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Val Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Ser Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asn Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2542
<211>  1178
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2542

Met Thr Glu Arg Gln Thr Ser Ser Lys Phe Asn Glu Leu Phe Glu Asn 
1               5                   10                  15      


Lys Cys Asn Leu Cys Ser Ile Ser Glu Lys Ala Phe Arg Asn Leu Gln 
            20                  25                  30          


Leu Lys Val Ser Arg Phe Ser Lys Asp Asn Ala Lys Lys Asn Tyr Ile 
        35                  40                  45              


Cys Asp Asn Thr Lys Leu Gln Pro Ser Ala Val His Tyr Phe Ala Ile 
    50                  55                  60                  


Gly His Thr Phe Lys Asn Phe Asp Val Asn Asp Val Phe Glu Met Lys 
65                  70                  75                  80  


Val Asp Gly Asn Ser Leu Asn Lys Thr Ala Thr Lys Phe Arg His Leu 
                85                  90                  95      


Leu Asp Thr Lys Asp Asn Arg Glu Asn Gly Phe Phe Asp Ile Asp Arg 
            100                 105                 110         


Ile Phe Lys Leu Ile Gln Asp Ile Arg His Ile Asn Ser His Tyr Ile 
        115                 120                 125             


His Asp Phe Glu Asn Ile Ala Ile Asp Asp Ser Asp Asn Leu Phe Ile 
    130                 135                 140                 


Phe Leu Lys Glu Ser Phe Glu Leu Ala Ser Leu Asn Val Ser Gly Ile 
145                 150                 155                 160 


Ile Gly Lys Glu Asp Gln Asn Lys Lys Leu Ala Asn Phe Leu Tyr Asp 
                165                 170                 175     


Lys Phe His Leu Ser Ile Lys Lys Asn Ser Thr Lys Asp Glu Cys Ile 
            180                 185                 190         


Glu Asp Ile Leu Phe Ile Asp Asn Thr Lys Glu Asp Lys Lys Thr Glu 
        195                 200                 205             


Trp Thr Leu Lys Asn Gly Lys Lys Ala Phe Asp Ile Asn Pro Asn Lys 
    210                 215                 220                 


Tyr Leu Ser Phe Tyr Ala Cys Leu Phe Leu Leu Ser Met Phe Leu Tyr 
225                 230                 235                 240 


Lys Asp Glu Ser Asn Leu Leu Ile Ser Arg Ile Lys Gly Phe Lys Arg 
                245                 250                 255     


Asn Glu Thr Glu Glu Glu Gln Ala Lys Arg Asn Val Phe Thr Phe Tyr 
            260                 265                 270         


Ser Lys Lys Leu Ser Ser Gln Asp Ile Asp Ser Glu Glu Ser Asp Leu 
        275                 280                 285             


Val Lys Phe Arg Asp Ile Ile Gln Tyr Leu Asn Lys Tyr Pro Tyr Ala 
    290                 295                 300                 


Trp Thr Lys Ala Tyr Asn Asp Lys Glu Ile Ser Arg Glu Phe Lys Asp 
305                 310                 315                 320 


Lys Phe Ile Lys Asn Ile Leu Lys Phe Glu Ile Glu Arg Ala Leu Leu 
                325                 330                 335     


Asn Asn Asp Lys Asn Arg Phe Tyr Phe Ile Lys Asp Glu Glu Lys Glu 
            340                 345                 350         


Ala Phe Tyr Leu Tyr Thr Met Tyr Gln Val Trp Gly Leu Asp Lys Ser 
        355                 360                 365             


Lys Phe Lys Lys Met Ser Phe Thr Leu Ser Gln Ile Asp Asn Phe Asn 
    370                 375                 380                 


Asn Val Ile Thr His Ser Leu Lys Ile Gln Gly Ile Leu Lys Glu Gln 
385                 390                 395                 400 


Lys Glu Leu Ile Lys Lys Tyr Gly Lys Phe Asp Lys Lys Val Lys Asp 
                405                 410                 415     


Leu Glu Thr Lys Leu Lys Thr Ala Ile Lys Thr Asp Lys Val Asn Ala 
            420                 425                 430         


Glu Lys Glu Ile Lys Ala Arg Gly Lys Glu Ile Gly Met Pro Ala Ser 
        435                 440                 445             


Phe Glu Ile Glu Lys Ile Lys Thr Arg Phe Tyr Asn Gly Lys Leu Phe 
    450                 455                 460                 


Asn Ser Tyr Gly Arg Asn Thr Asp Lys Phe Met Lys Tyr Ala Thr Arg 
465                 470                 475                 480 


Phe Leu Ala Glu Asn Lys Phe Phe Gly Glu Glu Ala Lys Phe Lys Cys 
                485                 490                 495     


Tyr Lys Trp Phe Thr Ser Asp Glu Gln Asn Val Asp Ile Ile Lys Leu 
            500                 505                 510         


Lys Gly Ser Leu Ser Lys Lys Glu Phe Asp Ser Leu Lys Tyr His Gln 
        515                 520                 525             


Gly Arg Leu Ile Glu Tyr Ile Lys Tyr Ser Asp Phe Leu Glu Lys Lys 
    530                 535                 540                 


Glu His Asn Tyr Ile Pro Phe Val Ile Gln Asn Asn Ala Ile Gln Val 
545                 550                 555                 560 


Lys Ile Thr Ile Asp Gly Phe Glu Arg Ile Leu Ser Ile Gln Arg Lys 
                565                 570                 575     


Leu Met Val Asn Leu Leu His Tyr Ala Leu Ser Asp Tyr Ser Ser Gln 
            580                 585                 590         


Lys Lys Ser Ser Asp Pro Leu Ser Asn Arg Ser Ile Asn Asn Leu Gly 
        595                 600                 605             


Leu Asp Leu Ile Thr Ser Tyr Tyr Lys Glu Tyr Lys Asn Asp Phe Asn 
    610                 615                 620                 


Asn Gly Ile Glu Tyr Leu Lys Gln Ile Glu Glu Ile Asp Thr Asn Lys 
625                 630                 635                 640 


Phe Ser Asn Leu Asn Lys Leu Phe Pro Lys Arg Leu Leu His Asn Tyr 
                645                 650                 655     


Ser Ser Asn Tyr Glu Tyr Lys Ala Pro Glu Ile Ser Val Asn Lys Gln 
            660                 665                 670         


Phe Leu Glu Lys Thr Lys Glu Gln Asn Lys Lys Tyr Asn Glu Leu Tyr 
        675                 680                 685             


Glu Glu Ala Lys Asn Lys Asp Ile Leu Glu Asp Phe Leu Lys Lys Asn 
    690                 695                 700                 


Lys Gly Lys Lys Tyr Lys Leu Asp Phe Ile Lys Lys Ala Trp Asn Gln 
705                 710                 715                 720 


Met Tyr Phe Lys Glu Ile Tyr Leu Glu Gln Thr Asn Ile Ala Lys Ser 
                725                 730                 735     


His His Lys Gly Phe Asn Ile Thr Lys Glu Glu Tyr Asn Asp Phe Cys 
            740                 745                 750         


Lys Ala Met Tyr Ser Phe Asn Gly Tyr Asp Asp Val Tyr Lys Lys Phe 
        755                 760                 765             


Leu Thr Asp Leu Phe Lys Ser Lys Lys Phe Leu Asp Asn Gln Glu Phe 
    770                 775                 780                 


Lys Thr Leu Phe Asn Asp Ser Glu Cys Leu Glu Asp Leu Tyr Ile Lys 
785                 790                 795                 800 


Thr Ile Lys Ala Tyr Glu Lys Trp Leu Asp Asn Ser Ser His Ile Lys 
                805                 810                 815     


Asn Thr Glu Glu Lys Phe Lys Leu Asn Ser Tyr Lys Phe Ile Asn Glu 
            820                 825                 830         


Pro Asn Lys His Ile Leu Tyr Ile Asn Ile Ser His Phe Leu Asn Phe 
        835                 840                 845             


Leu Lys Lys Gln Asn Lys Ile Asn Val Lys Asn Asn Gln Ile Gln Tyr 
    850                 855                 860                 


Ile Leu Leu Tyr Gln His Lys Ser Val Leu Ile Gln Glu Tyr Tyr Leu 
865                 870                 875                 880 


Asp Tyr Lys Ser Ile Asn Lys Asn Asp Lys Ala Ser Leu Arg Leu Phe 
                885                 890                 895     


Asn Lys Leu Asn Asp Ile Arg Phe Glu Asp Val Leu Leu Tyr Glu Ile 
            900                 905                 910         


Ala Ile Trp Tyr Phe Glu Leu Asp Lys Thr Thr Val Lys Asn Leu Lys 
        915                 920                 925             


Asn Ile Asp Val Arg Lys Ile Tyr Asn Ser Asp Ile Thr Tyr Lys Phe 
    930                 935                 940                 


Asn Lys Ile Ser Val Val Val Pro Phe Lys Lys Leu Leu Asp Phe Glu 
945                 950                 955                 960 


Leu Trp Leu Asn Arg Asp Tyr Glu Lys Ser Lys Ser Lys Lys Asn Asn 
                965                 970                 975     


Gly Thr Tyr Ile Thr Lys Ile Ser Thr Tyr Leu Asp Ile Leu Glu Lys 
            980                 985                 990         


Glu Ile Lys Thr Ser Tyr Thr Asn  Cys His Glu Ser Lys  Arg Val Asp 
        995                 1000                 1005             


Leu Asn  Asp Leu Thr Glu Val  Met Asn Ser Tyr Ser  Glu Asn Lys 
    1010                 1015                 1020             


Thr Leu  Ser Leu Asp Ser Phe  Tyr Lys Phe Asn Thr  His Leu Val 
    1025                 1030                 1035             


Asn Asn  Ala Arg Lys Phe Ser  Arg Ile Trp Leu Val  Leu Glu Glu 
    1040                 1045                 1050             


Tyr Tyr  Ile Lys Lys Tyr Asp  Lys Asp Leu Asn Ile  Ile Phe Lys 
    1055                 1060                 1065             


Asp His  Arg Ile Glu Tyr Glu  Glu Leu Glu Phe Leu  Lys Asn Tyr 
    1070                 1075                 1080             


Lys Arg  Lys Ser Ser Lys Asn  Met Arg Asp Met Arg  Asn Ala Ala 
    1085                 1090                 1095             


Phe His  Ile Asn Ile Pro Met  Asn Tyr Ser Phe His  Leu Ala Ile 
    1100                 1105                 1110             


Lys Met  Ile Gly Lys Arg Phe  Ile Gln Glu Glu Ile  Lys Thr Leu 
    1115                 1120                 1125             


Pro Lys  Ser Val Ser Val Leu  Ser Lys Asp Ile Gln  Ser Val Cys 
    1130                 1135                 1140             


Gly Glu  Phe Ile Asn Ile Leu  Tyr Pro Ile Lys Tyr  Ser Lys Ser 
    1145                 1150                 1155             


Asp Ser  Asp Cys Lys Trp Lys  Ser Tyr Asp Arg Ile  Ile Lys Tyr 
    1160                 1165                 1170             


Tyr Leu  Thr Glu Ala 
    1175             


<210>  2543
<211>  1196
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2543

Met Lys Thr Ser Lys Glu Phe Glu Asn Tyr Asn Ser Arg Asn Ser Phe 
1               5                   10                  15      


Lys Lys Ile Phe Asp Phe Lys Gly Glu Ile Ala Pro Ile Ala Glu Lys 
            20                  25                  30          


Ala Asn Arg Asn Leu Glu Leu Lys Thr Lys Asn Glu Thr Asn Leu Val 
        35                  40                  45              


Gln Arg Val His Tyr Phe Ala Ile Gly His Thr Phe Lys Tyr Ile Asp 
    50                  55                  60                  


Thr Glu Thr Leu Phe Glu Trp Val Val Asp Glu Glu Thr Gln Met Lys 
65                  70                  75                  80  


Gln Pro Thr Lys Phe Leu Ser Leu Gln Ser Phe Asp Asp Ser Phe Cys 
                85                  90                  95      


Asp Glu Leu Gln Lys Ile Thr Val Val Gly Thr Asn Asn Glu Tyr Asn 
            100                 105                 110         


Gly Leu Ile Pro Ala Ile Arg Asn Ile Asn Ser His Tyr Ile His Ser 
        115                 120                 125             


Phe Glu Lys Ile Arg Ile Asp Ser Leu Ser Pro Val Met Val Lys Phe 
    130                 135                 140                 


Leu Lys Glu Ser Phe Glu Leu Ser Val Ile Gln Ile Tyr Ile Lys Glu 
145                 150                 155                 160 


Glu Asn Glu Leu Lys Arg Ser Lys Asn Glu Arg Leu Ala Ser Thr Lys 
                165                 170                 175     


Glu Ile Ile Glu Gln Asn Gly Phe Gly Lys Arg Leu Val Gln Phe Leu 
            180                 185                 190         


Cys Asp Lys Phe Tyr Pro Val Gly Asn Lys Thr Thr Tyr Pro Glu Asp 
        195                 200                 205             


Tyr Leu Glu Tyr Arg Lys Gln Phe Arg Asn Leu Ser Lys Asp Glu Ala 
    210                 215                 220                 


Ile Asp Ser Leu Leu Phe Val Glu Val Glu Thr Ala Phe Asp Trp Leu 
225                 230                 235                 240 


Leu Phe Glu Thr Tyr Pro Ala Phe Asn Ile Ala Val Gly Lys Tyr Leu 
                245                 250                 255     


Ser Phe Tyr Ser Cys Leu Phe Leu Leu Ser Met Phe Leu Tyr Lys Ser 
            260                 265                 270         


Glu Ala Asn Gln Leu Ile Ser Lys Ile Lys Gln Phe Lys Arg Asn Lys 
        275                 280                 285             


Ile Gln Glu Glu Lys Ser Lys Arg Glu Ile Phe Thr Phe Phe Ser Lys 
    290                 295                 300                 


Arg Phe Ser Ser Gln Asp Ile Asp Ser Glu Glu Asn His Leu Val Lys 
305                 310                 315                 320 


Phe Arg Asp Leu Ile Gln Tyr Leu Asn Arg Tyr Pro Val Ala Trp Asn 
                325                 330                 335     


Lys Asp Ile Glu Leu Glu Ser Gln His Pro Val Met Thr Asp Arg Leu 
            340                 345                 350         


Lys Ala Lys Ile Ile Glu Met Glu Ile Asp Ser Ser Phe Pro Ile Tyr 
        355                 360                 365             


Ala Glu Asn Asn Arg Phe His Val Phe Ala Lys Tyr Gln Ile Trp Gly 
    370                 375                 380                 


Lys Lys Tyr Phe Gly Lys Lys Ile Glu Lys Glu Tyr Ile Glu Gln Ser 
385                 390                 395                 400 


Phe Asn Gly Asn Glu Val Glu Glu Phe Ser Tyr Glu Ile Asn Thr Ser 
                405                 410                 415     


Pro Glu Leu Lys Gly Phe Tyr Leu Lys Leu Ala Asp Leu Lys Ser Lys 
            420                 425                 430         


Pro Gly Leu Tyr Glu Lys His Lys Ala Glu Ile Lys Arg Thr Glu Thr 
        435                 440                 445             


Ser Ile Lys Glu Leu Ile Glu Gln Asn Val Pro Asn Pro Ile Thr Glu 
    450                 455                 460                 


Lys Leu Lys Thr Arg Ile Glu Lys Asn Leu Leu Phe Val Ser Tyr Gly 
465                 470                 475                 480 


Arg Asn Gln Asp Arg Phe Met Asp Phe Ala Thr Arg Tyr Leu Ala Glu 
                485                 490                 495     


Thr Asn Tyr Phe Gly Asn Asp Ala Arg Phe Lys Met Tyr Gln Phe Tyr 
            500                 505                 510         


Thr Thr Thr Glu Gln Asn Lys Glu Tyr Glu Asn Leu Lys Glu Val Lys 
        515                 520                 525             


Ser Lys Lys Glu Ile Asp Arg Leu Lys Phe His His Gly Arg Pro Ile 
    530                 535                 540                 


His Phe Ser Thr Tyr Ser Asn His His Lys Arg Tyr Glu Ser Trp Asp 
545                 550                 555                 560 


Thr Pro Phe Val Phe Glu Asn Asn Ala Ile Gln Val Lys Met Thr Leu 
                565                 570                 575     


Asp His Gly Ile Glu Lys Thr Val Ser Ile Gln Arg Ser Leu Met Val 
            580                 585                 590         


Tyr Leu Leu Glu Asp Ala Leu Phe Lys Ala Asp Lys Ser Met Val Asp 
        595                 600                 605             


Ser Ala Gly Lys His Leu Ile Ser Glu Tyr Phe Thr His Gln Gln Gln 
    610                 615                 620                 


Asp Phe Asn Tyr Ser Arg Leu Val Leu Glu Gln Asn Glu Ser Ile Asn 
625                 630                 635                 640 


Thr Glu Gln Lys Asn Lys Phe Lys Lys Ile Leu Pro Lys Arg Leu Leu 
                645                 650                 655     


Asn His Tyr Leu Pro Ala Ile Gln Asn Asn Thr Pro Ala Phe Ser Thr 
            660                 665                 670         


Leu Gln Leu Ile Leu Glu Lys Ala Lys Leu Ala Glu Glu Arg Tyr Lys 
        675                 680                 685             


Lys Leu Thr Glu Lys Val Lys Thr Glu Gly Asn Tyr Asp Asp Phe Ile 
    690                 695                 700                 


Lys Arg Asn Lys Gly Lys Gln Phe Lys Leu Gln Phe Ile Arg Lys Ala 
705                 710                 715                 720 


Trp His Leu Met Tyr Phe Lys Glu Ser Tyr Lys Gln Gln Ala Ser Phe 
                725                 730                 735     


Ser Gly His His Lys Arg Phe His Ile Glu Arg Asp Glu Phe Asn Asp 
            740                 745                 750         


Phe Ser Arg Phe Met Phe Ala Phe Asp Glu Val Pro Ala Tyr Lys Asp 
        755                 760                 765             


Tyr Leu Lys Gln Leu Leu Asp Lys Lys Gly Phe Phe Glu Asn Gln Gln 
    770                 775                 780                 


Phe Lys Ala Leu Phe Glu Asn Gly Thr Ser Leu Asp Asn Leu Tyr Val 
785                 790                 795                 800 


Lys Thr Lys Gln Ala Tyr Glu Lys Trp Leu Ile Gly Gln Asn Asn Arg 
                805                 810                 815     


Glu Leu Glu Ala Thr Lys Tyr Thr Leu Gln Ser Tyr Glu Gln Phe Phe 
            820                 825                 830         


Ala Asp Asp Met Phe Tyr Ile Asn Gln Ser His Phe Ile Ser Phe Leu 
        835                 840                 845             


Glu Ser Lys Ser Leu Leu Ser Arg Asp Glu Gln Gly Gln Met Arg Phe 
    850                 855                 860                 


Asn Ala Leu Ala Asn Cys Ala Phe Leu Val Ser Glu Phe Tyr Tyr Thr 
865                 870                 875                 880 


Asp Lys Leu Asp Lys Thr Glu Tyr Lys Thr Asn Arg Lys Leu Phe Asn 
                885                 890                 895     


Gln Leu Arg Ser Val Arg Leu Glu Asp Ala Leu Leu Tyr Glu Met Ala 
            900                 905                 910         


Met Cys Tyr Leu Lys Ile Asp Gln Gln Val Val Gln Lys Ala Lys Ala 
        915                 920                 925             


His Val Ile Glu Ile Leu Thr Gln Asn Val Gln Phe Asp Ile Cys Asn 
    930                 935                 940                 


Ser Gln Asp Lys Leu Val Tyr His Leu Val Ile Pro Phe Asn Lys Ile 
945                 950                 955                 960 


Asp Ala Tyr Val Glu Leu Leu Asn Arg Lys Glu Thr Asp Glu Thr Ile 
                965                 970                 975     


Ser Ser Gly Ser Ser Phe Ile Thr Asn Val Asp Lys Tyr Ile Glu Met 
            980                 985                 990         


Ile Trp Asn Glu Ile Pro Trp Lys  Glu Lys Asn Glu Asn  Ala Lys Lys 
        995                 1000                 1005             


Ile Thr  His Ala Ala Met Tyr  Pro Ile Gly Glu Lys  Tyr Ser Arg 
    1010                 1015                 1020             


Gln Lys  Thr Ile Thr Tyr Asp  Asp Leu Gln Lys Ile  Tyr Gln His 
    1025                 1030                 1035             


Leu Leu  Ser Ser Ser Asn Lys  Leu Thr Asn Val Ser  Met Gln Ile 
    1040                 1045                 1050             


Glu Arg  Tyr Tyr Leu Cys Lys  Pro Asp Gly Gln Gly  His Val Val 
    1055                 1060                 1065             


Phe Asn  Gly Glu Thr Asp Arg  Lys Thr Gly Cys Tyr  Leu Ile Arg 
    1070                 1075                 1080             


Phe Glu  Lys Thr Gly Val Pro  Lys Thr Tyr Phe Gly  Val Gly Glu 
    1085                 1090                 1095             


Leu Asn  Ile Arg Asn Lys Ala  Phe His Phe Leu Ile  Thr Pro Ser 
    1100                 1105                 1110             


Lys Ser  Tyr Glu Lys Trp Leu  Met Asp Val Glu Arg  Glu Phe Ile 
    1115                 1120                 1125             


Leu Lys  Glu Val Lys Pro Asn  Asn Pro Lys Ala Tyr  Thr Asp Leu 
    1130                 1135                 1140             


Asn Arg  Ser Val Lys Leu Val  Cys Asp Ile Leu Leu  Asn Thr Leu 
    1145                 1150                 1155             


His Asn  Asn Tyr Phe Lys Leu  Thr Asp Ser Asp Lys  Gly Ile Pro 
    1160                 1165                 1170             


Lys Glu  Glu Gln Gly Lys Gln  Lys Gln Lys Asn Ala  Gln Ile Thr 
    1175                 1180                 1185             


Tyr Phe  Thr Lys His Ile Leu  Tyr 
    1190                 1195     


<210>  2544
<211>  1196
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2544

Met Lys Thr Ser Lys Glu Phe Glu Asn Tyr Asn Ser Arg Asn Ser Phe 
1               5                   10                  15      


Lys Lys Ile Phe Asp Phe Lys Gly Glu Ile Ala Pro Ile Ala Glu Lys 
            20                  25                  30          


Ala Asn Arg Asn Leu Glu Leu Lys Thr Lys Asn Glu Thr Asn Leu Val 
        35                  40                  45              


Gln Arg Val His Tyr Phe Ala Ile Gly His Thr Phe Lys Tyr Ile Asp 
    50                  55                  60                  


Thr Glu Thr Leu Phe Glu Trp Val Val Asp Glu Glu Thr Gln Met Lys 
65                  70                  75                  80  


Gln Pro Thr Lys Phe Leu Ser Leu Gln Ser Phe Asp Asp Ser Phe Cys 
                85                  90                  95      


Asp Glu Leu Gln Lys Ile Thr Val Val Gly Thr Asn Asn Glu Tyr Asn 
            100                 105                 110         


Gly Leu Ile Pro Ala Ile Arg Asn Ile Asn Ser His Tyr Ile His Ser 
        115                 120                 125             


Phe Glu Lys Ile Arg Ile Asp Ser Leu Ser Pro Val Met Val Lys Phe 
    130                 135                 140                 


Leu Lys Glu Ser Phe Glu Leu Ser Val Ile Gln Ile Tyr Ile Lys Glu 
145                 150                 155                 160 


Glu Asn Glu Leu Lys Arg Ser Lys Asn Glu Arg Leu Ala Ser Thr Lys 
                165                 170                 175     


Glu Ile Ile Glu Gln Asn Gly Phe Gly Lys Arg Leu Val Gln Phe Leu 
            180                 185                 190         


Cys Asp Lys Phe Tyr Pro Val Gly Asn Lys Thr Thr Tyr Pro Glu Asp 
        195                 200                 205             


Tyr Leu Glu Tyr Arg Lys Gln Phe Arg Asn Leu Ser Lys Asp Glu Ala 
    210                 215                 220                 


Ile Asp Ser Leu Leu Phe Val Glu Val Glu Thr Ala Phe Asp Trp Leu 
225                 230                 235                 240 


Leu Phe Glu Thr Tyr Pro Ala Phe Asn Ile Ala Val Gly Lys Tyr Leu 
                245                 250                 255     


Ser Phe Tyr Ser Cys Leu Phe Leu Leu Ser Met Phe Leu Tyr Lys Ser 
            260                 265                 270         


Glu Ala Asn Gln Leu Ile Ser Lys Ile Lys Gln Phe Lys Arg Asn Lys 
        275                 280                 285             


Ile Gln Glu Glu Lys Ser Lys Arg Glu Ile Phe Thr Phe Phe Ser Lys 
    290                 295                 300                 


Arg Phe Ser Ser Gln Asp Ile Asp Ser Glu Glu Asn His Leu Val Lys 
305                 310                 315                 320 


Phe Arg Asp Leu Ile Gln Tyr Leu Asn Arg Tyr Pro Val Ala Trp Asn 
                325                 330                 335     


Lys Asp Ile Glu Leu Glu Ser Gln His Pro Val Met Thr Asp Arg Leu 
            340                 345                 350         


Lys Ala Lys Ile Ile Glu Met Glu Ile Asp Ser Ser Phe Pro Ile Tyr 
        355                 360                 365             


Ala Glu Asn Asn Arg Phe His Val Phe Ala Lys Tyr Gln Ile Trp Gly 
    370                 375                 380                 


Lys Lys Tyr Phe Gly Lys Lys Ile Glu Lys Glu Tyr Ile Glu Gln Ser 
385                 390                 395                 400 


Phe Asn Gly Asn Glu Val Glu Glu Phe Ser Tyr Glu Ile Asn Thr Ser 
                405                 410                 415     


Pro Glu Leu Lys Gly Phe Tyr Leu Lys Leu Ala Asp Leu Lys Ser Lys 
            420                 425                 430         


Pro Gly Leu Tyr Glu Lys His Lys Ala Glu Ile Lys Arg Thr Glu Thr 
        435                 440                 445             


Ser Ile Lys Glu Leu Ile Glu Gln Asn Val Pro Asn Pro Ile Thr Glu 
    450                 455                 460                 


Lys Leu Lys Thr Arg Ile Glu Lys Asn Leu Leu Phe Val Ser Tyr Gly 
465                 470                 475                 480 


Arg Asn Gln Asp Arg Phe Met Asp Phe Ala Thr Arg Tyr Leu Ala Glu 
                485                 490                 495     


Thr Asn Tyr Phe Gly Asn Asp Ala Arg Phe Lys Met Tyr Gln Phe Tyr 
            500                 505                 510         


Thr Thr Thr Glu Gln Asn Lys Glu Tyr Glu Asn Leu Lys Glu Val Lys 
        515                 520                 525             


Ser Lys Lys Glu Ile Asp Arg Leu Lys Phe His His Gly Arg Pro Ile 
    530                 535                 540                 


His Phe Ser Thr Tyr Ser Asn His His Lys Arg Tyr Glu Ser Trp Asp 
545                 550                 555                 560 


Thr Pro Phe Val Phe Glu Asn Asn Ala Ile Gln Val Lys Met Thr Leu 
                565                 570                 575     


Asp His Gly Ile Glu Lys Thr Val Ser Ile Gln Arg Ser Leu Met Val 
            580                 585                 590         


Tyr Leu Leu Glu Asp Ala Leu Phe Lys Ala Asp Lys Ser Met Val Asp 
        595                 600                 605             


Ser Ala Gly Lys His Leu Ile Ser Glu Tyr Phe Thr His Gln Gln Gln 
    610                 615                 620                 


Asp Phe Asn Tyr Ser Arg Leu Val Leu Glu Gln Asn Glu Ser Ile Asn 
625                 630                 635                 640 


Thr Glu Gln Lys Asn Lys Phe Lys Lys Ile Leu Pro Lys Arg Leu Leu 
                645                 650                 655     


Asn His Tyr Leu Pro Ala Ile Gln Asn Asn Thr Pro Ala Phe Ser Thr 
            660                 665                 670         


Leu Gln Leu Ile Leu Glu Lys Ala Lys Leu Ala Glu Glu Arg Tyr Lys 
        675                 680                 685             


Lys Leu Thr Glu Lys Val Lys Thr Glu Gly Asn Tyr Asp Asp Phe Ile 
    690                 695                 700                 


Lys Arg Asn Lys Gly Lys Gln Phe Lys Leu Gln Phe Ile Arg Lys Ala 
705                 710                 715                 720 


Trp His Leu Met Tyr Phe Lys Glu Ser Tyr Lys Gln Gln Ala Ser Phe 
                725                 730                 735     


Ser Gly His His Lys Arg Phe His Ile Glu Arg Asp Glu Phe Asn Asp 
            740                 745                 750         


Phe Ser Arg Phe Met Phe Ala Phe Asp Glu Val Pro Ala Tyr Lys Asp 
        755                 760                 765             


Tyr Leu Lys Gln Leu Leu Asp Lys Lys Gly Phe Phe Glu Asn Gln Gln 
    770                 775                 780                 


Phe Lys Ala Leu Phe Glu Asn Gly Thr Ser Leu Asp Asn Leu Tyr Val 
785                 790                 795                 800 


Lys Thr Lys Gln Ala Tyr Glu Lys Trp Leu Ile Gly Gln Asn Asn Arg 
                805                 810                 815     


Glu Leu Glu Ala Thr Lys Tyr Thr Leu Gln Ser Tyr Glu Gln Phe Phe 
            820                 825                 830         


Ala Asp Asp Met Phe Tyr Ile Asn Gln Ser His Phe Ile Ser Phe Leu 
        835                 840                 845             


Glu Ser Lys Ser Leu Leu Ser Arg Asp Glu Gln Gly Gln Met Arg Phe 
    850                 855                 860                 


Asn Ala Leu Ala Asn Cys Ala Phe Leu Val Ser Glu Phe Tyr Tyr Thr 
865                 870                 875                 880 


Asp Lys Leu Asp Lys Thr Glu Tyr Lys Thr Asn Arg Lys Leu Phe Asn 
                885                 890                 895     


Gln Leu Arg Ser Val Arg Leu Glu Asp Ala Leu Leu Tyr Glu Met Ala 
            900                 905                 910         


Met Cys Tyr Leu Lys Ile Asp Gln Gln Val Val Gln Lys Ala Lys Ala 
        915                 920                 925             


His Val Ile Glu Ile Leu Thr Gln Asn Val Gln Phe Asp Ile Cys Asn 
    930                 935                 940                 


Ser Gln Asp Lys Leu Val Tyr His Leu Val Ile Pro Phe Asn Lys Ile 
945                 950                 955                 960 


Asp Ala Tyr Val Glu Leu Leu Asn Arg Lys Glu Thr Asp Glu Thr Ile 
                965                 970                 975     


Ser Ser Gly Ser Ser Phe Ile Thr Asn Val Asp Lys Tyr Ile Glu Met 
            980                 985                 990         


Ile Trp Asn Glu Ile Pro Trp Lys  Glu Lys Asn Glu Asn  Ala Lys Lys 
        995                 1000                 1005             


Ile Thr  His Ala Ala Met Tyr  Pro Ile Gly Glu Lys  Tyr Ser Arg 
    1010                 1015                 1020             


Gln Lys  Thr Ile Thr Tyr Asp  Asp Leu Gln Lys Ile  Tyr Gln His 
    1025                 1030                 1035             


Leu Leu  Ser Ser Ser Asn Lys  Leu Thr Asn Val Ser  Met Gln Ile 
    1040                 1045                 1050             


Glu Arg  Tyr Tyr Leu Cys Lys  Pro Asp Gly Gln Gly  His Val Val 
    1055                 1060                 1065             


Phe Asn  Gly Glu Thr Asp Arg  Lys Thr Gly Cys Tyr  Leu Ile Arg 
    1070                 1075                 1080             


Phe Glu  Lys Thr Gly Val Pro  Lys Thr Tyr Phe Gly  Val Gly Glu 
    1085                 1090                 1095             


Leu Asn  Ile Arg Asn Lys Ala  Phe His Phe Leu Ile  Thr Pro Ser 
    1100                 1105                 1110             


Lys Ser  Tyr Glu Lys Trp Leu  Met Asp Val Glu Arg  Glu Phe Ile 
    1115                 1120                 1125             


Leu Lys  Glu Val Lys Pro Asn  Asn Pro Lys Ala Tyr  Thr Asp Leu 
    1130                 1135                 1140             


Asn Arg  Ser Val Lys Leu Val  Cys Asp Ile Leu Leu  Asn Thr Leu 
    1145                 1150                 1155             


His Asn  Asn Tyr Phe Lys Leu  Thr Asp Ser Asp Lys  Gly Ile Pro 
    1160                 1165                 1170             


Lys Glu  Glu Gln Gly Lys Gln  Lys Gln Lys Asn Ala  Gln Ile Thr 
    1175                 1180                 1185             


Tyr Phe  Thr Lys His Ile Leu  Tyr 
    1190                 1195     


<210>  2545
<211>  1145
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2545

Met Glu Thr Leu Thr Ile Pro Glu Val Ile Lys Cys Arg Thr Leu Ser 
1               5                   10                  15      


Asp Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Ile Ala Lys Glu Phe Asp Leu Pro Leu 
        35                  40                  45              


Leu Ala Glu Glu Gly His Leu Lys Asn Ser Phe Leu Cys Lys Lys Glu 
    50                  55                  60                  


His Asn Lys Val Asn Trp Asn His Val Tyr Ser Arg Thr Lys Arg Phe 
65                  70                  75                  80  


Leu Ala Val Leu Lys Val Phe Asp Ala Glu Thr Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Lys Thr Ile Asn Trp Glu Gly Lys Asp Phe Ala Ser Met Ser Asp 
            100                 105                 110         


Ile Leu Lys Ile Val Phe Gly Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Thr Ile Arg Lys Thr Ala Val 
    130                 135                 140                 


Ser Ala Glu Met Ala Leu Phe Leu Thr Thr Asn Phe Arg Arg Ala Ile 
145                 150                 155                 160 


Glu Tyr Thr Lys Glu Arg Phe Lys Gly Val Leu Asn Asp Glu Asp Tyr 
                165                 170                 175     


Gln Leu Val Ala Ser Lys Lys Val Leu Glu Ala Asn Ser Thr Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Arg Phe Ile Gly Ile Ile Thr Gly Leu Lys Gly Thr Gln Asn 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro His Asp Arg Phe Gln Ser Asp Asn Pro Arg Gln Ala Phe Ser 
                245                 250                 255     


Leu Asp Leu Ile Asn Glu Leu Asn Arg Cys Pro Lys Val Leu Tyr Asn 
            260                 265                 270         


Ala Ile Thr Glu Glu Gly Lys Gln Lys Leu Arg Ser Ile Pro Gly Glu 
        275                 280                 285             


Leu Glu Asn Lys Asn Leu His Asp Asn Asn Thr Lys Lys Glu Ala Lys 
    290                 295                 300                 


Ile Glu Ala Glu Ala Tyr Glu Leu Tyr Ile Glu Ser Leu Thr Arg Gln 
305                 310                 315                 320 


Ile Arg Tyr Ser Asn Arg Phe Pro Asp Phe Ala Leu Lys Phe Ile Asp 
                325                 330                 335     


Glu Thr Asp Ile Phe Ser Glu Phe Arg Phe Gln Ile Asp Leu Gly Lys 
            340                 345                 350         


Leu Leu Val Asp Glu Tyr Leu Lys Phe Phe Asn Gly Glu His Val Gln 
        355                 360                 365             


Arg Arg Ile Val Glu Asn Ala Lys Ala Phe Gly Lys Leu Ile Asp Phe 
    370                 375                 380                 


Asn Asp Glu Ala Lys Val Met Thr Arg Ile Gly Asn Gly His Phe Ser 
385                 390                 395                 400 


Lys Arg Phe Glu Gln Phe Ala Pro Phe Tyr Asn Thr Glu Asp Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Arg His His Val Thr Ala Lys Leu Gly Pro Asp Ser 
            420                 425                 430         


Lys Gly Glu Pro Glu Lys Lys Leu Leu Gln Pro Leu Pro Glu Ala Phe 
        435                 440                 445             


Leu Ser Leu His Glu Leu Pro Lys Val Ile Leu Leu Asp Tyr Leu Gln 
    450                 455                 460                 


Lys Gly Glu Pro Glu Lys Leu Ile Asn Asp Phe Ile Leu Ile Asn Asn 
465                 470                 475                 480 


Ser Lys Leu Met Asn Met Ser Phe Ile Glu Ala Val Lys Thr Gln Leu 
                485                 490                 495     


Pro Pro Glu Trp Asp Glu Phe Gln Arg Arg Thr Gly Ser Lys Asn Glu 
            500                 505                 510         


Met Pro Tyr Asn Glu Lys Thr Leu Ala Tyr Leu Leu Gln Arg Lys Gln 
        515                 520                 525             


Ile Leu Asn Lys Ile Leu Ala Glu Phe Gln Leu Asn Asp Lys Gln Ile 
    530                 535                 540                 


Pro Gly Arg Ile Leu Asp Tyr Trp Leu Asn Ile Ala Asp Val Glu Glu 
545                 550                 555                 560 


Glu Arg Ala Val Ser Asp Arg Ile Lys Ser Ile Lys Arg Asp Cys Met 
                565                 570                 575     


Ser Arg Leu Arg Ala Leu Gly Lys Phe Lys Ile Asp Arg Asn Arg Asn 
            580                 585                 590         


Lys Ile Pro Lys Ile Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile 
        595                 600                 605             


Val Asp Met Val Val Ser Glu Gly Lys Lys His Lys Ile Thr Ser Phe 
    610                 615                 620                 


Tyr Tyr Glu Lys Met Gln Asp Cys Leu Ser Leu Phe Ala Asp Pro Leu 
625                 630                 635                 640 


Lys Arg Gln Leu Phe Ile His Ile Ile Thr Asn Glu Leu Arg Leu Asn 
                645                 650                 655     


Asp Ser Gly Gly His Pro Phe Leu Phe Lys Leu Asn Met Arg Gln Ile 
            660                 665                 670         


Asn Cys Thr Ser Asp Phe Tyr Glu Ile Tyr Leu Gln Glu Lys Gly His 
        675                 680                 685             


Lys Met Val Pro Glu Lys Asn Leu Lys Thr Gly Lys Val Val Asn Thr 
    690                 695                 700                 


Asp His Ser Trp Met Ala Leu Thr Phe Tyr Lys Leu Glu Phe Asn Asp 
705                 710                 715                 720 


Lys Val Asp Lys Leu Met Thr Val Val Lys Leu Pro Leu Asn Lys Leu 
                725                 730                 735     


Asn Leu Pro Phe Thr Leu Arg Gln Leu Asn Ala Lys Thr Thr Tyr Thr 
            740                 745                 750         


Leu Glu Gln Trp Leu Lys Asn Leu Thr Leu Gly Lys Lys Pro Asp Asp 
        755                 760                 765             


Gly Lys His Pro Val Asn Leu Pro Thr Asn Leu Phe Asp Glu Lys Leu 
    770                 775                 780                 


Ser Asp Leu Leu Arg Gln Asp Leu Asp Asn Asn Lys Ile Ala Tyr Arg 
785                 790                 795                 800 


Pro Tyr Ala Asn Trp Asn Glu Leu Phe Lys Ile Trp Trp Ile Ser Arg 
                805                 810                 815     


Asn Asp Ser Leu Gln Arg Phe Tyr Asn Ala Glu Arg Glu Tyr His Ile 
            820                 825                 830         


Phe Asn Glu Lys Val Asn Phe Tyr Pro Asn Arg Lys Glu Asn Phe Ala 
        835                 840                 845             


Asp Tyr Tyr Gln His Ala Val Lys Val Ala Phe Gln Lys Lys Arg Asn 
    850                 855                 860                 


Glu Arg Ile Ile Glu Gln Arg Ile Asn Lys Tyr Leu Pro Asp Ile Leu 
865                 870                 875                 880 


Phe Glu Gln Val Glu Lys Thr Phe Lys His Thr Ile Ala Glu Thr Glu 
                885                 890                 895     


Lys Glu Ile Arg Ile Leu Gln Glu Glu Asp Arg Ile Met Leu Leu Met 
            900                 905                 910         


Leu Glu Gly Leu Met Glu Asp Gly Asn Lys Gln Gln Leu Lys Leu Ser 
        915                 920                 925             


Glu Ile Lys Thr Leu Gln Asn Ala Thr Ile Asn Ile Arg Gln Leu Val 
    930                 935                 940                 


Pro Gly Lys Leu Ser Phe Asp Asp Ser Gly Glu Ala Ile Lys Asp Ser 
945                 950                 955                 960 


Thr Asn Pro Glu Ile Val Arg Thr Val Ser Val Ser Ile Lys Arg Ile 
                965                 970                 975     


Glu Tyr Asn Leu Leu Pro Lys Tyr Val Ala Asp Gly Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Pro Asp Glu  Glu Ile Gln Met Glu  Arg Leu Lys 
        995                 1000                 1005             


Thr Glu  Phe Asp Thr Tyr Asn  Lys Val Arg Gln Val  Val Leu Asp 
    1010                 1015                 1020             


Leu Ser  Phe Lys Leu Glu Lys  Met Ile Ile Glu Lys  Gly His Lys 
    1025                 1030                 1035             


Asp Arg  Ile Asn Gln Leu Cys  Thr Gly Ala Thr Gly  Glu Leu Leu 
    1040                 1045                 1050             


Thr Gly  Asn Ile Cys His His  Thr Tyr Leu Thr Trp  Leu Lys Asp 
    1055                 1060                 1065             


Lys Glu  Met Ile Asp Asn Glu  Thr Phe Ile Phe Met  Asn Met Val 
    1070                 1075                 1080             


Gln His  Cys Phe Ser His Asn  Gln Tyr Pro Gln Lys  Lys Thr Met 
    1085                 1090                 1095             


Glu Arg  Ile Ile Asn His Trp  Glu Pro Asp Arg Phe  Ala Leu Thr 
    1100                 1105                 1110             


Ile Ala  Ala Thr Tyr Asn Gln  Lys Ile Ala Gly Ile  Leu Glu Asp 
    1115                 1120                 1125             


Ile Gly  Thr Phe Pro Phe Ile  Arg Ser Arg Lys Thr  Met Pro Asp 
    1130                 1135                 1140             


Val Val  
    1145 


<210>  2546
<211>  1156
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2546

Met Glu Leu Ser Gln Ala Val Leu Ala Ala Phe Tyr Asn Asp Ala Arg 
1               5                   10                  15      


Leu Asn Ile Leu Ala Cys Leu Asn Asp Ile Arg Asn Lys Gln Gly Leu 
            20                  25                  30          


Ser Leu Met Gln Gly Asp Glu His Ile Val Ser Ala Phe Tyr Asp Leu 
        35                  40                  45              


Ser Gln Ile Leu Thr Asn Gly Thr Pro Glu Glu Ser Ser Ala Leu Ile 
    50                  55                  60                  


Lys Asp Leu Arg Tyr Arg Phe Pro Phe Leu Asp Ala Arg Thr Asp Ala 
65                  70                  75                  80  


Ser Glu Lys Asn Lys Gly Phe Thr Pro Leu Pro Glu Asn Tyr His Gln 
                85                  90                  95      


Ile Leu Glu Trp Met Phe Lys Leu Leu Asn Gly Leu Arg Asn Ser Val 
            100                 105                 110         


Val His Pro Cys Asp Gln Pro Phe Leu Ile Asp Ile Glu Leu His Lys 
        115                 120                 125             


Asn Ile Phe Phe Leu Leu Asn Asp Ile Tyr Asp Asp Gly His Arg Leu 
    130                 135                 140                 


Leu Lys Thr Arg Phe Asp Trp Thr Thr Asn Asp Ile Lys Pro Leu Leu 
145                 150                 155                 160 


Arg Tyr Asp Gln Arg Gly Lys Leu Lys Ile Lys Arg Phe Ser Phe Val 
                165                 170                 175     


Leu Cys Ser Asp Pro Lys Lys Arg Ser Asn Ser Pro Val Leu Gly Gln 
            180                 185                 190         


Lys Lys Val Phe Tyr Ser Phe Gly His Val Leu Phe Cys Ser Leu Phe 
        195                 200                 205             


Leu Asp Lys Ser Gln Ser Ala Asp Leu Ile Ser His Phe Trp Glu Ser 
    210                 215                 220                 


Gly His Gly Lys Phe Trp Gln Asp Asn Lys Tyr Arg Glu Met Ile Lys 
225                 230                 235                 240 


Glu Leu Ile Ser Phe Tyr Arg Val Arg Leu Pro Leu Leu Arg Leu Lys 
                245                 250                 255     


Ala Asp Ser Gln Thr Thr Leu Thr Ile Asp Ala Leu Ser Glu Leu Ser 
            260                 265                 270         


Arg Cys Pro Arg Pro Leu Leu Gly Ala Leu Ser Gln Gln Asp Lys Asn 
        275                 280                 285             


Lys Phe Arg Glu Val Val Asp Asp Val Asp Thr Asp Asn Asn Ser Gln 
    290                 295                 300                 


Gln Ser Ser Thr Tyr Leu Leu Ala Arg Ser His Gln Asn Arg Phe Ile 
305                 310                 315                 320 


Pro Leu Met Met Ser Phe Phe Glu Gln Ser Ala Asn Ser Arg Leu Arg 
                325                 330                 335     


Phe Ala Ile Asp Phe Gly His Phe Tyr Phe Asn Val Arg Leu Lys Ser 
            340                 345                 350         


Gly Ser His Phe Thr Asp Asn Glu Pro Arg Val Arg Arg Ile Gly Gln 
        355                 360                 365             


Lys Ile Ile Gly Tyr Gly His Leu Gln Ala Val Glu Lys Pro Ile Ile 
    370                 375                 380                 


Trp Gln Gln Leu Gln Asp Asn Phe Thr Ser Ser Asn Asp Glu Ala Ile 
385                 390                 395                 400 


Asn Ala Lys Ala Ser Ile Ser Lys Gln Ser Asn Thr Asp Glu Gln Leu 
                405                 410                 415     


Gln Leu Lys Pro Tyr Leu Val Lys Thr Phe Ala His Tyr His Phe Asp 
            420                 425                 430         


Glu His Lys Ile Gly Phe Lys Leu Val Gln Asp Asn Asp Leu Ser Ala 
        435                 440                 445             


Phe Pro Asp Leu Pro Ala Asp Ile Asp Val Thr Glu Pro Ile Lys Leu 
    450                 455                 460                 


Thr Lys Ile Ser Gly Gln Leu Met Gln Pro Asp Phe Trp Met Ser Pro 
465                 470                 475                 480 


Ala Gln Met Leu His Leu Ser Phe Tyr Tyr Tyr Leu Tyr Glu Gln Tyr 
                485                 490                 495     


Pro Asp Ser Ala Thr Asn Ser Asn Ser Lys Ser Val Asp Val Leu Phe 
            500                 505                 510         


Asn Ile Tyr Arg Gly Gly Ile Gln Arg Leu Phe Gln Asn Leu Phe Glu 
        515                 520                 525             


Ala Ser Pro Ser Leu Ser Gly Glu Pro Phe Ser Glu Glu Arg His Gln 
    530                 535                 540                 


Ala Val Gln Ala Tyr Ile Asn Asn Tyr Phe Asn Thr Asp Asp Phe Thr 
545                 550                 555                 560 


Ile Ser Met Ala Asp Leu Pro Lys Val Ile Val Arg His Leu Leu Gly 
                565                 570                 575     


Ala Glu Asp Lys Pro Ile Ser Lys Leu Gln Ile Ile Gln Arg Ala Lys 
            580                 585                 590         


Gln Leu Lys Glu Lys Thr Glu Gln Lys Ile His Gln Leu Glu His Leu 
        595                 600                 605             


Gln Asn Ala Tyr Lys Lys Arg Gly His Lys Asp Phe Arg Pro Ile Lys 
    610                 615                 620                 


Cys Gly His Ile Gly Asp Phe Leu Ser Glu Asp Leu Ile Arg Phe Gln 
625                 630                 635                 640 


Ala Val Asn Lys Ala Gln Ala Asp Gly Gly Lys Leu Asn Ser Gln Gln 
                645                 650                 655     


Tyr Gln Ile Leu Gln Ala Thr Leu Ala Tyr Tyr Gly Lys Tyr Ile Asp 
            660                 665                 670         


Gln Pro Pro Lys Val Ile Asp Leu Phe Lys Asn Phe Gly Leu Leu Asp 
        675                 680                 685             


Gly Glu Phe Arg His Pro Phe Leu Tyr Lys Leu Gly Leu Gln Asn Asn 
    690                 695                 700                 


Pro Glu Lys Tyr Gln Gly Leu Leu Ala Phe Tyr Glu Asp Tyr Leu Val 
705                 710                 715                 720 


Ala Arg Lys Asn Tyr Leu Lys Asp Tyr Ile Lys Glu Thr Glu Ala Ser 
                725                 730                 735     


Asp Ser Pro Lys Ala Ala His Trp Leu Arg Leu Lys Gln Ile Ser Thr 
            740                 745                 750         


Leu Gln Gly Trp Phe Asn Glu Asn Leu Thr Ser Asn Gln Lys Leu Lys 
        755                 760                 765             


Gln Pro Leu Pro Ile Ala Lys Asn Phe Phe Tyr Gln Pro Ile Leu Lys 
    770                 775                 780                 


Leu Leu Ala Asp Val Leu Lys Gln Gly Pro Glu Asp Leu Gln Lys Asn 
785                 790                 795                 800 


Gly Met Gln Cys Phe Ile Arg Gly Gly Lys Glu Val Gln Ile Arg Pro 
                805                 810                 815     


Ala Ile Ser Trp Phe Ile His Tyr Tyr Gln Gln Ser Lys Asp Asp Asn 
            820                 825                 830         


Val Gln Glu Met Tyr Gly Phe Lys Arg Asn His Glu Val Phe Asp Asn 
        835                 840                 845             


Phe Leu Asp Arg Arg Gly Asn Asn Ser Phe Lys Glu Arg Lys Ile His 
    850                 855                 860                 


Phe Leu Ser Glu Asp Glu Arg Lys Ser His Leu Pro Glu Ile Arg Gln 
865                 870                 875                 880 


Lys Ile Gln Ile Leu Asp Gln Gln Ile Thr Glu Gln Asp Lys Gln Asn 
                885                 890                 895     


Lys Thr Asp Lys Ala Lys Gln Tyr Tyr Lys Leu Ile Asn Asp Leu Lys 
            900                 905                 910         


Ala Tyr Lys Lys Gln Glu Lys Val Ile Arg His Thr Ala Thr Gln Asp 
        915                 920                 925             


Ile Leu Leu Ser Leu Tyr Val Arg Gln Asn Leu Lys His Leu Met Gln 
    930                 935                 940                 


Asn Ser Asp Asp Ile Asn Trp Lys Leu Asn Asn Ile Glu Asn Ser Leu 
945                 950                 955                 960 


Leu Asn Glu Ser Ile Tyr His Cys Phe Ser Ile Pro Asp Ser Thr Lys 
                965                 970                 975     


Lys Leu Phe His Pro Asp Cys Lys Ile Arg Lys Leu Gly Glu Leu Arg 
            980                 985                 990         


Leu Leu Ala Arg Asp Lys Arg Leu  Pro Ser Leu Leu Glu  Tyr Tyr Pro 
        995                 1000                 1005             


Ala Glu  Glu Thr Glu Ile Asn  Gln Ala Glu Ile Arg  Ala Glu Leu 
    1010                 1015                 1020             


Asn Asp  Tyr Arg Arg Ala Arg  Ile Asp Ile Met Arg  Ala Val His 
    1025                 1030                 1035             


Thr Leu  Glu Lys Lys Ile Ser  Ser Val Cys Gly Leu  Pro Glu Lys 
    1040                 1045                 1050             


Gly Ser  Val Pro Ile Asp Arg  Glu Ala Phe Phe Gly  Lys Ala Arg 
    1055                 1060                 1065             


His Gly  Glu Tyr Leu Tyr His  Leu Cys Val Ala Asn  Ser Asp Lys 
    1070                 1075                 1080             


Ile Gly  Phe Lys Gln Glu Asp  Phe Tyr Lys Ala Leu  Leu Ile Arg 
    1085                 1090                 1095             


Asn Ala  Phe Ala His Ser Glu  Tyr Pro Lys Thr Glu  Tyr Phe Pro 
    1100                 1105                 1110             


Glu Ile  Val Ala Ala Thr Arg  Ser Glu Ala Ile Pro  Glu Asn Pro 
    1115                 1120                 1125             


Ala Leu  Asn Arg Asn Ile Ala  Leu Arg Leu Ala Glu  Glu Leu Lys 
    1130                 1135                 1140             


Arg Leu  Tyr Gln Pro Trp Leu  Asp Phe Leu Ser Gly  Ala 
    1145                 1150                 1155     


<210>  2547
<211>  1094
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2547

Met Lys Lys Tyr Tyr Asp Leu Tyr Lys Lys Asp Asp Lys His Phe Phe 
1               5                   10                  15      


Ala Gly Leu Phe Asn Thr Ala Val Asn Asn Phe Asp Leu Ser Ile Arg 
            20                  25                  30          


Glu Leu Glu Arg Arg Ile Lys Ser Lys Ser Asn Asn Ser Ile Gly Val 
        35                  40                  45              


Leu Lys Phe Ala Phe Ser Asn Glu Arg Pro Phe His Glu Leu Glu Asn 
    50                  55                  60                  


Asn Phe Asn Phe Leu Lys Glu Ser Leu Val Phe Met Asn Glu Ile Asn 
65                  70                  75                  80  


Gly Phe Tyr Asn Lys Lys Lys Thr Asn Lys Asp Ile Pro Glu Ser Gln 
                85                  90                  95      


Asn Ile Tyr Leu Phe Thr Gly Asp Phe Leu Val Glu Leu Tyr Asn Thr 
            100                 105                 110         


Leu Asn Ser Leu Arg Asn Tyr Tyr Thr His Tyr Glu His Ser Asp Ile 
        115                 120                 125             


Glu Ile Gly Asn Asp Ile Ala Asp Phe Leu Asn Asp Val Leu Phe His 
    130                 135                 140                 


Ser Ala Ile Arg Ile Lys Lys Asp Arg Ala Lys Asn Ala Asp Val Lys 
145                 150                 155                 160 


Ala Arg Leu Lys Thr Lys Tyr Lys Thr Glu Ile Asp Glu Tyr Phe Lys 
                165                 170                 175     


Ala His Asn Asn Lys Gly Glu Val Lys His Lys Ile Lys Gln Glu Asp 
            180                 185                 190         


Lys Thr Asn Tyr Val Ile Asn Lys Met Phe Asn Val Phe Phe Tyr Glu 
        195                 200                 205             


Asp Lys Asp Lys Asn Ile Phe Glu Leu Lys Asn Leu Val Lys Thr Lys 
    210                 215                 220                 


Asn Asn Glu Thr Asn Arg Leu Thr Lys Ser Gly Ile Ala Leu Val Leu 
225                 230                 235                 240 


Ser Leu Phe Leu Thr Lys Lys Gln Ile Asn Leu Leu Phe Asp Asn Phe 
                245                 250                 255     


Lys Tyr Phe Tyr Asp Asp Asp Ser Glu Leu Gln Lys Leu Ile Ile Arg 
            260                 265                 270         


Trp Val Tyr Thr Tyr Arg Ser Tyr Lys Ser Ile Arg Tyr Leu Phe Lys 
        275                 280                 285             


Ser Asp Tyr Asp Thr His Ser Leu Leu Leu Gln Met Val Asn Glu Leu 
    290                 295                 300                 


Asn Lys Ala Pro Lys His Leu Tyr Pro Tyr Leu Ser Glu Ala Lys Lys 
305                 310                 315                 320 


Lys Glu Phe Ile Glu Asp Val Asn Ile Tyr Leu Lys Asp Asn Ala Lys 
                325                 330                 335     


Asn Tyr Asp Asp Ser Leu Val Ala His Glu Val Ile Arg Arg Arg Tyr 
            340                 345                 350         


Glu Glu Lys Phe Ala Tyr Phe Ala Leu Arg Phe Leu Asp Asp Phe Ile 
        355                 360                 365             


Glu Phe Pro Thr Leu Arg Phe His Val Asn Leu Gly Lys Phe Asn His 
    370                 375                 380                 


Asn Ser Met Lys Lys Thr Tyr Lys Asn Asn Leu Ile Thr Glu Arg Ser 
385                 390                 395                 400 


Ile Leu Glu Lys Ile Asn Val Phe Glu Lys Leu Thr Met Val Thr Lys 
                405                 410                 415     


Lys Lys Lys Glu Tyr Phe Gln Asn Asn Asn Ile Asp Thr Glu Glu Gly 
            420                 425                 430         


Trp Arg Glu Phe Pro Met Pro Lys Tyr Val Phe His Gly Asn Ser Ile 
        435                 440                 445             


Gly Ile Tyr Leu Gly Lys Arg Asp Glu Val Glu Met Lys Arg Glu Glu 
    450                 455                 460                 


Asn Lys Pro Thr Lys Thr Ala Leu Ile Glu Lys Leu Gly Leu Pro Lys 
465                 470                 475                 480 


Asp Ala Tyr Gln Lys Pro Met Ala Phe Leu Ser Val Tyr Glu Leu Pro 
                485                 490                 495     


Ala Leu Leu His Tyr Leu Leu Val Asp Arg Lys Thr Pro Lys Glu Val 
            500                 505                 510         


Glu Glu Lys Ile Thr Gln Gln Ile Asn Lys Gln Lys Lys Glu Leu Asn 
        515                 520                 525             


Ser Ile Asp Glu Ser Asn Ile Ser Asp Ile Lys Ile Lys Lys Asp Ile 
    530                 535                 540                 


Ser Ile Asn Asn Lys Ile Ile Arg Lys Leu Thr Lys Ile Asn Asp Leu 
545                 550                 555                 560 


Lys Asn Phe Tyr Asp Leu Glu Lys Ile Lys Lys Ile Ile Glu Glu Glu 
                565                 570                 575     


Ile Lys Ile Ser Asp Pro Glu Asn Glu Lys Ser Pro Leu Lys Glu Ile 
            580                 585                 590         


Arg Lys Asn Tyr Lys Lys Thr Pro Lys Asn Pro Asn Ile Leu Ser Asn 
        595                 600                 605             


Ser Glu Lys Gly Lys Ile Ala Thr Trp Leu Ser Lys Asp Ile Lys Arg 
    610                 615                 620                 


Phe Thr Lys Lys Glu Val Arg Glu Asn Trp Lys Gly Tyr Gln Phe Ala 
625                 630                 635                 640 


Glu Phe Gln Ser Leu Leu Ser Tyr Tyr Asp Ile Asp Lys Asn Ala Val 
                645                 650                 655     


Lys Asn Phe Leu Leu Glu Asp Leu Tyr Glu Asn Lys Asn Leu Gln Asn 
            660                 665                 670         


Asn Phe Leu Leu Lys Asn Leu Asn Phe Asn Asn Ile Thr Leu Tyr Glu 
        675                 680                 685             


Phe Tyr Ile Asp Tyr Leu Thr Lys Arg Asn Thr Tyr Leu Glu Lys Lys 
    690                 695                 700                 


Leu Leu Leu Lys Leu Leu Gln Gly Lys Asp Lys Thr Asp Glu Ile Phe 
705                 710                 715                 720 


Val Phe Leu Pro Lys Asn Lys Phe Val Leu Thr Asp Ile Lys Asn Tyr 
                725                 730                 735     


Lys Ile Arg Lys Asn Asn Ala Pro Ile Met Leu Ser Arg Gly Ile Phe 
            740                 745                 750         


Tyr Asp Glu Pro Thr Gly Tyr Lys Pro Asp Asp Tyr Asn Lys Lys Asn 
        755                 760                 765             


Glu Leu Ala Glu Trp Phe Thr Lys Ala Ser Asp Ile Asp Lys Ala Gln 
    770                 775                 780                 


Glu Phe Tyr Lys Tyr Gln Arg Gln Tyr Pro Ile Asp Asp Asn Asn Phe 
785                 790                 795                 800 


Leu Ser Ile Asn Thr Asp Lys Gly Leu Lys Asp Gln Phe Ser Tyr Phe 
                805                 810                 815     


Glu Lys Thr Glu Asn Asn Gly Tyr Ile Thr Lys Thr Ile Asp Lys Lys 
            820                 825                 830         


Gln Gln Lys Phe Ile Tyr Lys Asn Glu Ala Lys Ile Arg Arg Thr Met 
        835                 840                 845             


Arg Asn Asp Tyr Tyr Ile Leu Gln Met Ile Lys His Phe Tyr Lys Glu 
    850                 855                 860                 


Ser Thr Glu Ile Asp Lys Gln Arg Leu Asp Lys Ile Thr Leu Lys Asp 
865                 870                 875                 880 


Phe Tyr Leu Thr Lys Ala Glu Lys Glu Lys Ile Gln Lys Glu Ala Ser 
                885                 890                 895     


Glu Lys Gln Asn Glu Phe Asn Gln Asp Phe Ile Leu Arg Lys Lys Val 
            900                 905                 910         


Glu Ile Ser Met Tyr Glu Gly Lys Ile Lys Gly Glu Val Lys Leu Lys 
        915                 920                 925             


Glu Ser Gly Lys Tyr Lys Arg Leu Leu Leu Asp Ser Lys Val Lys Met 
    930                 935                 940                 


Leu Thr Glu Tyr Phe Pro Asp Lys Lys Trp Thr Ile Asp Asp Ile Met 
945                 950                 955                 960 


Leu Glu Leu Asp Asn Tyr Glu Gln Val Arg Ser Lys Glu Phe Phe Lys 
                965                 970                 975     


Asn Val His Gln Leu Glu Gln Ile Ile Tyr Thr Lys Ala Asp Glu Gln 
            980                 985                 990         


Lys Glu Leu Glu Lys Leu Leu Leu  Asn Gly Phe Pro Asn  Phe Arg Lys 
        995                 1000                 1005             


Tyr Leu  Val Tyr Tyr Tyr Glu  Cys Pro Lys Leu Asp  Asn Ile Asn 
    1010                 1015                 1020             


Val Ile  Lys Thr Lys Leu Thr  Asp Leu Glu Thr Glu  Lys Glu Lys 
    1025                 1030                 1035             


Leu Leu  Phe Ile Leu Ile Met  Leu Arg Asn Lys Phe  Ala His Asn 
    1040                 1045                 1050             


Gln Leu  Val Pro Lys Glu Ile  Phe Val Tyr Leu Gln  Glu Lys Tyr 
    1055                 1060                 1065             


Thr Ile  Asn Lys Asn Glu Lys  Ile Gly Thr Tyr Leu  Asn Arg Val 
    1070                 1075                 1080             


Phe Glu  Lys Ile Tyr Glu Glu  Leu Asn Asn Asn 
    1085                 1090                 


<210>  2548
<211>  1242
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2548

Met Glu Gln Asn Arg Lys Glu Gly Ser Leu Arg Thr Gln Glu Asp Ile 
1               5                   10                  15      


Gln Tyr Phe Gly Ser Tyr Phe Asn Met Ala Arg His Asn Leu Tyr Leu 
            20                  25                  30          


Ile Thr Asn His Leu Thr Ser Val Phe Ser His Leu Asn Phe Ser Gln 
        35                  40                  45              


Leu Asp Asp Asp Glu Asp Ile Trp Ser Asp Lys Pro Glu Val Asn Glu 
    50                  55                  60                  


Lys Asn Ile Leu Leu Asn Ile Phe Asp Thr Lys Asn Glu Arg Leu Gln 
65                  70                  75                  80  


Asp Glu Arg Ile Arg Val Phe Arg Tyr Leu Met Arg Arg His His Leu 
                85                  90                  95      


Pro Cys Leu Arg Ile Phe Thr Asn Asp Phe Lys Val Leu Glu Thr Thr 
            100                 105                 110         


Gly Asn Thr Ile Lys Lys Asp Glu Leu Glu Val Asp Phe Asp Ala Val 
        115                 120                 125             


His Lys Phe Leu Asn Ile Ala Phe Lys Glu Ile Asn Leu Phe Arg Asn 
    130                 135                 140                 


Ser Tyr Thr His Tyr Leu Ser Ile Asn Glu Glu Gly Lys Arg Leu Lys 
145                 150                 155                 160 


Lys Lys Lys Lys Ile Ser Ser Lys Leu Val Pro Val Leu Asn Ser Leu 
                165                 170                 175     


Phe Ser Tyr Ala Pro Glu Tyr Ser Phe Leu Arg His Asn Ile Asp Lys 
            180                 185                 190         


Ala Asn Lys Asp Val Lys Ile Tyr Lys Glu Glu Val Lys Glu Tyr Tyr 
        195                 200                 205             


Asp Asn Ile Lys Ser Lys Tyr Lys Leu Phe Glu Asn Asp Ser Asn Glu 
    210                 215                 220                 


Leu Thr Asp Gln Gly Met Tyr Phe Phe Ile Thr Leu Phe Leu Glu Arg 
225                 230                 235                 240 


Ala His Gly Ile Lys Phe Leu Lys Arg Phe Arg Gly Phe Lys Asn Glu 
                245                 250                 255     


Thr Thr Pro Pro Phe Lys Ala Thr Ile Gln Ala Phe Thr Thr Tyr Thr 
            260                 265                 270         


Leu Lys Ile Pro Asp Val Arg Leu Asp Asn Asp Ile Pro Glu Gln Thr 
        275                 280                 285             


Met Ile Met Glu Val Leu Asn Glu Leu Asn Lys Cys Pro Glu Glu Leu 
    290                 295                 300                 


Phe Lys Phe Leu Lys Lys Glu Asp Lys Asp Arg Phe Gln Pro Val Ile 
305                 310                 315                 320 


Ser Asp Glu Ser Leu Thr Asn Ile Ile Asn Ser Ser Asn Tyr Glu Glu 
                325                 330                 335     


Ile Ser Asp Glu Asp Ile Asp Arg Leu Ile Lys Glu Asn Ser Val Leu 
            340                 345                 350         


Lys Arg Arg Glu Asp Arg Phe Pro Tyr Phe Ala Leu Gln Tyr Leu Glu 
        355                 360                 365             


Ile Met Ser Lys Leu Lys Asn Ile Arg Phe Gln Ile Tyr Leu Gly Lys 
    370                 375                 380                 


Leu Val Leu Lys Thr Tyr Asp Lys Glu Asn Pro Asn Ile Glu Arg Arg 
385                 390                 395                 400 


Val Ile Thr Asp Ile His Ala Phe Gly Lys Leu Ser Asp Phe Val Gly 
                405                 410                 415     


Lys Glu Ala Glu Val Leu Asp Thr Phe Asn Ser Gln Leu Lys Asp Tyr 
            420                 425                 430         


Gly Tyr Ser Val Ala Trp Asp Gln Tyr Lys Pro Ser Tyr Ala Ile Glu 
        435                 440                 445             


Met Asn Arg Ile Gly Phe Tyr Leu Phe Asn Asp Gln Gly Asp Lys Val 
    450                 455                 460                 


Glu Asn Lys Ile Leu Pro Ser Leu Cys Lys Asn Lys Asn Leu Glu Arg 
465                 470                 475                 480 


Lys Val Glu Ile Lys Val Asn Lys Ile Gln Pro Thr Gly Phe Ile Ser 
                485                 490                 495     


Thr His Met Leu Pro Lys Phe Leu Ile Ser Tyr Leu Met Gly Asp Val 
            500                 505                 510         


Asn Glu Lys Asn Gly Glu Lys Thr Ile Thr His Phe Leu Glu Lys Val 
        515                 520                 525             


Asn Val Ser Ile Leu Asp Gln Asn Ile Ile Asn Gln Ile Lys Ser Glu 
    530                 535                 540                 


Ile Gln Asn Leu Asp Pro Ile Glu Phe Thr Lys Arg Cys Pro Lys Leu 
545                 550                 555                 560 


Ser Ala Ile Lys Asn Val Lys Lys Leu Arg Val Ala Gly Ala Ile Asp 
                565                 570                 575     


Lys Lys Ile Val Glu Tyr Gln Tyr Ile Asn Asp Thr Asp Ile Ala Lys 
            580                 585                 590         


Leu Val Gln Lys Thr Gly Leu Ala Tyr Asp Thr Met Val Thr Tyr Ser 
        595                 600                 605             


Lys Asp Lys Phe Lys Glu Lys Thr Asn His Leu Asn Leu Ser Lys Lys 
    610                 615                 620                 


Glu Leu Glu Thr Phe Ala His Ile Lys Tyr Lys Tyr Tyr Leu Ser Glu 
625                 630                 635                 640 


Arg Arg Lys Ala Leu Asp Ser Val Leu Lys Ala Tyr Phe Pro Glu Ile 
                645                 650                 655     


Gly Ser Gln Asp Ile Pro Lys Glu Leu Tyr Asn Tyr Leu Leu Asn Ile 
            660                 665                 670         


Asn Glu Gln Asp Asn Lys Lys Leu Glu His Arg Arg Ile Lys Asp Glu 
        675                 680                 685             


Val Thr Lys Thr Lys Lys Leu Ile Lys Asp Val Asn Arg Ser Leu Lys 
    690                 695                 700                 


Phe Glu Asp Lys Ile Leu Leu Gly Asp Leu Ala Thr Lys Ile Ala Arg 
705                 710                 715                 720 


Asp Ile Ile Asn Met Ile Ile Asp Lys Asp Leu Lys Val Ser Met Thr 
                725                 730                 735     


Asn Pro Phe Ala Asn Arg Leu Gln Asn Leu Ile Ala Tyr Phe Ser Thr 
            740                 745                 750         


Asn Lys Glu Ala Ile Val Ala Leu Cys Glu Ser Tyr Lys Val Phe Glu 
        755                 760                 765             


His Asn Lys Gly His Phe Phe Leu Thr Arg Glu Leu Ile Leu Asn Ser 
    770                 775                 780                 


Thr Gly Val Ile Asp Phe Tyr Ile Arg Tyr Phe Glu Ala Lys Ile Glu 
785                 790                 795                 800 


Lys Ile Lys Glu Val Leu Leu Val Arg Gly Lys Glu Gly Gly Tyr Glu 
                805                 810                 815     


Ile Asn Thr Glu Leu Ile Pro Tyr Ser Tyr Thr Gln Tyr Leu Pro Lys 
            820                 825                 830         


Glu Val Lys Glu Glu Asn Lys Asn Thr Cys Lys Asn Leu Phe Glu Gln 
        835                 840                 845             


Trp Leu Tyr Tyr Lys Gln Lys Ser Pro Val Asn Leu Pro Val Thr Leu 
    850                 855                 860                 


Leu Asp Glu Asp Leu Thr Ser Ala Leu Lys Ser Lys Leu Lys Leu Lys 
865                 870                 875                 880 


Pro Asp Leu Lys Asp Gly Phe Ser Lys Leu Ile Gln Leu Tyr Leu Lys 
                885                 890                 895     


Asp Asp Ala Gln Glu Phe Tyr Ser Phe Asp Arg Val Tyr Arg Asn Asn 
            900                 905                 910         


Asp Asn Glu His Val Ile Lys Tyr Ser Asn Glu Gly Ser Ser Lys Glu 
        915                 920                 925             


Met Gln Ile Lys Tyr Gly Lys Val Ala Val Glu Ser Glu Lys Ile Ile 
    930                 935                 940                 


Arg His Val Leu Leu Lys Asp Arg Ile Leu Arg Val Ile Cys Glu Asp 
945                 950                 955                 960 


Leu Leu Lys Ser Asp Lys Asn Thr Ser Ser Thr Lys Ser Phe Leu Leu 
                965                 970                 975     


Lys Asp Ile Ser Pro Trp Ser Glu Thr Asn Ile Leu Asn Lys Pro Asn 
            980                 985                 990         


Glu Phe Ser Tyr Asn Leu Arg Lys  Asn Ile Asp Gly Ser  Gly Thr Glu 
        995                 1000                 1005             


Tyr Cys  Thr Ile Val Ala Lys  Asp Ser Thr Glu Gln  Ile Arg Gln 
    1010                 1015                 1020             


Ile Asn  Glu Trp Asn Asp Leu  Ser Lys Glu Ile Lys  Ser Lys Phe 
    1025                 1030                 1035             


Leu Lys  Leu Asn Ala Glu Gln  Lys Ile Asp Phe Leu  Thr Thr Gln 
    1040                 1045                 1050             


Asp Glu  Lys Thr Lys Leu Val  Leu Leu Gly Gln Gln  Asn Tyr Gln 
    1055                 1060                 1065             


Trp Lys  Phe Ser Asp Phe Gly  Arg Phe Arg Arg Phe  Met Lys Asp 
    1070                 1075                 1080             


Lys Arg  Ile Asn Glu Met Val  Lys Tyr Phe Glu Pro  Lys Gln Ile 
    1085                 1090                 1095             


Pro Phe  Asp Leu Leu Glu Phe  Gln Ile Leu Gln Tyr  Asn Ile Tyr 
    1100                 1105                 1110             


Arg Glu  Lys Met Phe Asp Lys  Ile Phe Glu Leu Glu  Arg Val Met 
    1115                 1120                 1125             


Ser Glu  Arg Tyr Phe Glu Asp  Ile Lys Ser Lys His  Leu Glu Asn 
    1130                 1135                 1140             


Phe Lys  Tyr Asn Glu Val Gly  Phe Gln Thr Tyr Leu  Asn Val Leu 
    1145                 1150                 1155             


Ser Glu  Lys Ile Ala Ser Gly  Tyr Asp Ile Ala Ile  Leu Lys Trp 
    1160                 1165                 1170             


Gly Arg  Asn Lys Phe Ser His  Thr Glu Ile Val Tyr  Tyr Asn Phe 
    1175                 1180                 1185             


Ile Ser  Lys Ile Ala Val Gln  Asp Ile Glu Glu Phe  Glu Leu Lys 
    1190                 1195                 1200             


Lys His  Leu Glu Gly Tyr Lys  Glu Asn Val Ser Phe  Asn Ile Ala 
    1205                 1210                 1215             


Arg Asn  Ile Tyr Arg Val Phe  Ser Arg Glu Val Asp  Lys Thr Ile 
    1220                 1225                 1230             


Asn Leu  Ile Asn Asn Ser Phe  Lys Ile 
    1235                 1240         


<210>  2549
<211>  1160
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2549

Met Glu Gln Lys Gln Leu Glu Ser Arg Phe Asn Gln Ile Phe Asn Asn 
1               5                   10                  15      


Lys Gly His Thr Gly Pro Ile Ala Glu Lys Ala Val Lys Asn Phe Glu 
            20                  25                  30          


Thr Ile Arg Gln His Lys Val Ser Pro Arg Glu Arg Leu His Tyr Phe 
        35                  40                  45              


Ala Val Gly His Ala Leu Arg Asn Ile Asp Lys Asp Leu Lys Glu Ser 
    50                  55                  60                  


Ile Phe Glu Tyr Asn Leu Asp Glu Glu Gln Lys Lys Gln Lys Pro Thr 
65                  70                  75                  80  


Gln Phe Thr Thr Leu Gln Ser Asp Phe Phe Arg Phe Glu Asn Ala Leu 
                85                  90                  95      


Leu Thr Leu Leu Lys Asp Ile Arg Asn Cys Asn Gly His Tyr Val His 
            100                 105                 110         


Thr Phe Asp Lys Leu Gln Leu Asp Glu Ile Leu Lys Leu Gln Glu Lys 
        115                 120                 125             


Asn Lys Glu His Gly Ile Leu Asn Lys Asp Ala Gly Cys Gln Ile Ile 
    130                 135                 140                 


Glu Phe Leu Lys Glu Ala Phe Glu Phe Ser Ile Leu Ile Gln Phe Leu 
145                 150                 155                 160 


Lys Glu Lys Pro Lys Glu Tyr Glu Lys Phe Lys Lys Arg Lys Asn Glu 
                165                 170                 175     


Asn Lys Asn Gln Ser Leu Arg Asn Leu Ile Gly Gly Tyr Glu Lys Lys 
            180                 185                 190         


Leu Val Lys Tyr Leu Cys Asp Lys Phe Phe Pro Asn Glu Glu Lys Gln 
        195                 200                 205             


Lys Glu Ile Arg Asp Lys Phe Ile Glu His Asn Leu Glu Glu Ala Ile 
    210                 215                 220                 


Glu Asp Leu Leu Phe Ile Pro Val Asp Glu Asp Ile Glu Trp Lys Leu 
225                 230                 235                 240 


Gly Glu Glu His Val Val Phe Val Ile Lys Lys Gly Lys Tyr Leu Ser 
                245                 250                 255     


Phe Tyr Ala Gln Leu Phe Leu Leu Ser Met Phe Leu Tyr Lys Gln Glu 
            260                 265                 270         


Ala Asn Gln Leu Ile Ser Lys Ile Arg Gly Phe Lys Arg Ser Glu Asp 
        275                 280                 285             


Glu Phe Gln Tyr Lys Arg Asn Ile Phe Thr Phe Phe Ser Lys Lys Val 
    290                 295                 300                 


Ser Ser Gln Asp Ile His Ser Glu Glu Lys His Leu Ile Tyr Phe Arg 
305                 310                 315                 320 


Asp Ile Ile Gln Tyr Leu Asn Arg Phe Pro Thr Ala Trp Asn Glu Tyr 
                325                 330                 335     


Leu Ser Pro Glu Arg Lys Asn Leu Pro Met Thr Lys Leu Leu Glu Lys 
            340                 345                 350         


Tyr Ile Leu Glu Glu Glu Ile Phe Arg Thr Phe Ser Thr Tyr Lys Asn 
        355                 360                 365             


Asp Cys Asn Arg Glu Leu Phe Leu Lys Tyr Thr Ile Lys Arg Leu Phe 
    370                 375                 380                 


Arg Lys Lys Ala Glu Leu Phe Asp Ala Glu Lys Ile Ser Ile Asp Asp 
385                 390                 395                 400 


Asn Leu Arg Lys Lys Phe Asn Tyr Glu Ile Asp Thr Ser Pro Glu Leu 
                405                 410                 415     


Lys Asn Ile His Glu Lys Leu Lys Gly Lys Leu Lys Pro Lys Asp Tyr 
            420                 425                 430         


Tyr Lys Asn Ile Lys Arg Lys Glu Glu Leu Glu Lys Glu Glu Asn Pro 
        435                 440                 445             


Glu Lys Leu Lys Leu Ile Lys Lys Val Thr Glu Glu Lys Leu Phe Thr 
    450                 455                 460                 


Ala Tyr Gly Arg Asn Arg Asp Arg Phe Met Asp Phe Ala Val Arg Tyr 
465                 470                 475                 480 


Leu Ala Glu Gln Asn Tyr Phe Gly Lys Asp Ala Glu Phe Lys Met Tyr 
                485                 490                 495     


Met Phe Glu Thr Thr Asn Glu Gln Glu Asn Tyr Leu Lys Glu Gln Lys 
            500                 505                 510         


Asn Thr Ala Asp Lys Lys Val Ile Asp Gln Asn Lys Tyr His Gln Gly 
        515                 520                 525             


Arg Leu Thr Cys Phe Lys Thr Tyr Gln Lys His Lys Asp Asp Tyr Gln 
    530                 535                 540                 


Asn Trp Asp Asp Pro Phe Val Phe Gln Asn Asn Ala Phe Gln Ile Val 
545                 550                 555                 560 


Leu Thr Phe Ser Asn Gly Glu Arg Lys Lys Phe Ser Ile Gln Arg Lys 
                565                 570                 575     


Leu Leu Ile Tyr Leu Leu Glu Asp Ala Leu Phe Asn His Ser Asp Ser 
            580                 585                 590         


Ile Glu Asp Lys Gly Lys Gln Leu Leu Glu Asp Tyr Phe Phe Asn Thr 
        595                 600                 605             


Leu Met Pro Asp Phe Glu Glu Ala Lys Gly Ser Tyr Lys Thr Ser Asp 
    610                 615                 620                 


Asp Val Asn Trp Lys His Arg Lys Leu Leu Pro Lys Arg Leu Ile Tyr 
625                 630                 635                 640 


Thr Val His Pro Pro Arg Arg Thr Asp Ser Glu Glu Gln Ile His Pro 
                645                 650                 655     


Phe Glu Lys Ile Leu Arg Glu Thr Gln Glu Gln Glu Arg Arg Tyr Arg 
            660                 665                 670         


Leu Leu Leu Gly Lys Ala Lys Asn Met Lys Leu Lys Glu Glu Phe Ile 
        675                 680                 685             


Lys Arg Asn Lys Gly Lys His Phe Lys Leu Arg Phe Ile Arg Lys Ala 
    690                 695                 700                 


Trp His Leu Met Tyr Phe Arg Glu Ile Tyr Glu Arg Arg Ala Lys Glu 
705                 710                 715                 720 


His Ser His His Lys Ser Phe His Ile Thr Arg Asp Glu Ile Asn Asp 
                725                 730                 735     


Phe Ser Arg Trp Met Tyr Ala Phe Asp Glu Val Pro Pro Tyr Lys Val 
            740                 745                 750         


Tyr Leu Arg Asn Met Leu Gln Arg Lys Lys Phe Met Glu Asn Glu Glu 
        755                 760                 765             


Phe Ala Glu Leu Phe Glu Lys Gly Lys Ser Leu Asp Glu Phe Tyr His 
    770                 775                 780                 


Leu Thr Lys Gln Glu Phe Ser Lys Arg Ile Lys Asn Asn Leu Phe Gln 
785                 790                 795                 800 


Leu Lys Val Asp Ser Glu Arg Gln Tyr Ala Glu Val Leu Ser Lys Lys 
                805                 810                 815     


Leu Val Tyr Ile Asn Leu Ser His Phe Ile Lys Tyr Leu Asn Ala Lys 
            820                 825                 830         


Gly Lys Leu Thr Val Glu Asn Gly Ile Ile Gln Tyr Lys Ala Ser Thr 
        835                 840                 845             


Asn Lys Lys Tyr Leu Ile Asp Glu Tyr Tyr Tyr Thr Glu Val Leu Pro 
    850                 855                 860                 


Arg Glu Glu Tyr Lys Val His Lys His Leu Phe Asn Lys Leu Arg Ala 
865                 870                 875                 880 


Ala Lys Leu Glu Asp Ala Leu Leu Tyr Glu Leu Ala Met Lys Tyr Leu 
                885                 890                 895     


Lys Glu Asp Glu Glu Ile Val Glu Lys Ala Lys Ser Lys Val Ser Asp 
            900                 905                 910         


Ile Gln Ser Ser Glu Ile Ser Phe Asp Ile Lys Asp Tyr Tyr Gly Asn 
        915                 920                 925             


His Leu Tyr Thr Leu Ile Val Pro Phe Asn Lys Leu Glu Thr Leu Ser 
    930                 935                 940                 


Ile Leu Ile Arg Tyr Lys Thr Gly Gln Glu Asn Glu Leu Lys Asn Lys 
945                 950                 955                 960 


Lys Thr Ser Phe Leu Gly Asn Ile Tyr His Leu Leu Ala Phe Leu Asp 
                965                 970                 975     


Lys Asn Tyr Lys Gln Leu Ser Lys Tyr Lys Asp Asp Gly Gly Phe Lys 
            980                 985                 990         


Lys Ile Val Lys Asn Phe Lys Asn  Lys Lys Arg Leu Ser  Phe Val Glu 
        995                 1000                 1005             


Leu Asn  Thr Ile Asn Gly Tyr  Ile Ile Ser Gly Ala  Val Lys Phe 
    1010                 1015                 1020             


Ser Lys  Val His Met Glu Leu  Glu Arg Tyr Phe Ile  Asn Lys His 
    1025                 1030                 1035             


Lys Ile  Lys Ala Asn His Ile  Tyr Ile Asp Leu Glu  Asp Ile Lys 
    1040                 1045                 1050             


Asp Asp  Ser Asn Lys Gln Val  Phe Gly Asn Tyr Tyr  Asp Ser Lys 
    1055                 1060                 1065             


Leu Arg  Ile Arg Asn Lys Ala  Phe His Phe Gly Val  Pro Thr Asn 
    1070                 1075                 1080             


Phe Phe  Phe Asn Ile Glu Ile  Glu Lys Ile Glu Lys  Lys Phe Ile 
    1085                 1090                 1095             


Leu Glu  Glu Val Lys Leu Gln  Asn Val Ser Ser Phe  Asp Lys Leu 
    1100                 1105                 1110             


Asn Gln  Asn Ala Lys Ser Val  Cys Arg Val Phe Met  Glu Val Leu 
    1115                 1120                 1125             


His Ser  Asp Leu Tyr Arg Arg  Asp Lys Asn Lys Ser  Lys Glu Glu 
    1130                 1135                 1140             


Leu Arg  Arg Glu Phe Glu Glu  Lys Tyr Phe Asn Glu  Ile Ile Thr 
    1145                 1150                 1155             


Thr Val  
    1160 


<210>  2550
<211>  1140
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2550

Met Ser Lys Glu Cys Lys Lys Gln Arg Gln Glu Lys Lys Arg Arg Leu 
1               5                   10                  15      


Gln Lys Ala Asn Phe Ser Ile Ser Leu Thr Gly Lys His Val Phe Gly 
            20                  25                  30          


Ala Tyr Phe Asn Met Ala Arg Thr Asn Phe Val Lys Thr Ile Asn Tyr 
        35                  40                  45              


Ile Leu Pro Ile Ala Gly Val Arg Gly Asn Tyr Ser Glu Asn Gln Ile 
    50                  55                  60                  


Asn Lys Met Leu His Ala Leu Phe Leu Ile Gln Ala Gly Arg Asn Glu 
65                  70                  75                  80  


Glu Leu Thr Thr Glu Gln Lys Gln Trp Glu Lys Lys Leu Arg Leu Asn 
                85                  90                  95      


Pro Glu Gln Gln Thr Lys Phe Gln Lys Leu Leu Phe Lys His Phe Pro 
            100                 105                 110         


Val Leu Gly Pro Met Met Ala Asp Val Ala Asp His Lys Ala Tyr Leu 
        115                 120                 125             


Asn Lys Lys Lys Ser Thr Val Gln Thr Glu Asp Glu Thr Phe Ala Met 
    130                 135                 140                 


Leu Lys Gly Val Ser Leu Ala Asp Cys Leu Asp Ile Ile Cys Leu Met 
145                 150                 155                 160 


Ala Asp Thr Leu Thr Glu Cys Arg Asn Phe Tyr Thr His Lys Asp Pro 
                165                 170                 175     


Tyr Asn Lys Pro Ser Gln Leu Ala Asp Gln Tyr Gln His Gln Glu Met 
            180                 185                 190         


Ile Ala Lys Lys Leu Asp Lys Val Val Val Ala Ser Arg Arg Ile Leu 
        195                 200                 205             


Lys Asp Arg Glu Gly Leu Ser Val Asn Glu Val Glu Phe Leu Thr Gly 
    210                 215                 220                 


Ile Asp His Leu His Gln Glu Val Leu Lys Asp Glu Phe Gly Asn Ala 
225                 230                 235                 240 


Lys Glu Lys Asp Gly Lys Val Met Lys Thr Phe Val Glu Tyr Asp Asp 
                245                 250                 255     


Phe Tyr Phe Lys Ile Ser Gly Lys Arg Leu Val Asn Gly Tyr Thr Val 
            260                 265                 270         


Thr Thr Lys Asp Asp Lys Pro Val Asn Val Asn Thr Met Leu Pro Ala 
        275                 280                 285             


Leu Ser Asp Phe Gly Leu Leu Tyr Phe Cys Val Leu Phe Leu Ser Lys 
    290                 295                 300                 


Pro Tyr Ala Lys Leu Phe Ile Asp Glu Val Arg Leu Phe Glu Tyr Ser 
305                 310                 315                 320 


Pro Phe Asp Asp Lys Glu Asn Met Ile Met Ser Glu Met Leu Ser Ile 
                325                 330                 335     


Tyr Arg Ile Arg Thr Pro Arg Leu His Lys Ile Asp Ser His Asp Ser 
            340                 345                 350         


Lys Ala Thr Leu Ala Met Asp Ile Phe Gly Glu Leu Arg Arg Cys Pro 
        355                 360                 365             


Met Glu Leu Tyr Asn Leu Leu Asp Lys Asn Ala Gly Gln Pro Phe Phe 
    370                 375                 380                 


His Asp Glu Val Lys His Pro Asn Ser His Thr Pro Asp Val Ser Lys 
385                 390                 395                 400 


Arg Leu Arg Tyr Asp Asp Arg Phe Pro Thr Leu Ala Leu Arg Tyr Ile 
                405                 410                 415     


Asp Glu Thr Glu Leu Phe Lys Arg Ile Arg Phe Gln Leu Gln Leu Gly 
            420                 425                 430         


Ser Phe Arg Tyr Lys Phe Tyr Asp Lys Glu Asn Cys Ile Asp Gly Arg 
        435                 440                 445             


Val Arg Val Arg Arg Ile Gln Lys Glu Ile Asn Gly Tyr Gly Arg Met 
    450                 455                 460                 


Gln Glu Val Ala Asp Lys Arg Met Asp Lys Trp Gly Asp Leu Ile Gln 
465                 470                 475                 480 


Lys Arg Glu Glu Arg Ser Val Lys Leu Glu His Glu Glu Leu Tyr Ile 
                485                 490                 495     


Asn Leu Asp Gln Phe Leu Glu Asp Thr Ala Asp Ser Thr Pro Tyr Val 
            500                 505                 510         


Thr Asp Arg Arg Pro Ala Tyr Asn Ile His Ala Asn Arg Ile Gly Leu 
        515                 520                 525             


Tyr Trp Glu Asp Ser Gln Asn Pro Lys Gln Tyr Lys Val Phe Asp Glu 
    530                 535                 540                 


Asn Gly Met Tyr Ile Pro Glu Leu Val Val Thr Glu Asp Lys Lys Ala 
545                 550                 555                 560 


Pro Ile Lys Met Pro Ala Pro Arg Cys Ala Leu Ser Val Tyr Asp Leu 
                565                 570                 575     


Pro Ala Met Leu Phe Tyr Glu Tyr Leu Arg Glu Gln Gln Asp Asn Glu 
            580                 585                 590         


Phe Pro Ser Ala Glu Gln Val Ile Ile Glu Tyr Glu Asp Glu Tyr Arg 
        595                 600                 605             


Lys Phe Phe Lys Ala Val Ala Glu Gly Lys Leu Lys Pro Phe Lys Arg 
    610                 615                 620                 


Pro Lys Glu Phe Arg Asp Phe Leu Lys Lys Glu Tyr Pro Lys Leu Arg 
625                 630                 635                 640 


Met Ala Asp Ile Pro Lys Lys Leu Gln Leu Phe Leu Cys Ser His Gly 
                645                 650                 655     


Leu Cys Tyr Asn Asn Lys Pro Glu Thr Val Tyr Glu Arg Leu Asp Arg 
            660                 665                 670         


Leu Thr Leu Gln His Leu Glu Glu Arg Glu Leu His Ile Gln Asn Arg 
        675                 680                 685             


Leu Glu His Tyr Gln Lys Asp Arg Asp Met Ile Gly Asn Lys Asp Asn 
    690                 695                 700                 


Gln Tyr Gly Lys Lys Ser Phe Ser Asp Val Arg His Gly Ala Leu Ala 
705                 710                 715                 720 


Arg Tyr Leu Ala Gln Ser Met Met Glu Trp Gln Pro Thr Lys Leu Lys 
                725                 730                 735     


Asp Lys Glu Lys Gly His Asp Lys Leu Thr Gly Leu Asn Tyr Asn Val 
            740                 745                 750         


Leu Thr Ala Tyr Leu Ala Thr Tyr Gly His Pro Gln Val Pro Glu Glu 
        755                 760                 765             


Gly Phe Thr Pro Arg Thr Leu Glu Gln Val Leu Ile Asn Ala His Leu 
    770                 775                 780                 


Ile Gly Gly Ser Asn Pro His Pro Phe Ile Asn Lys Val Leu Ala Leu 
785                 790                 795                 800 


Gly Asn Arg Asn Ile Glu Glu Leu Tyr Leu His Tyr Leu Glu Glu Glu 
                805                 810                 815     


Leu Lys His Ile Arg Ser Arg Ile Gln Ser Leu Ser Ser Asn Pro Ser 
            820                 825                 830         


Asp Lys Ala Leu Ser Ala Leu Pro Phe Ile His His Asp Arg Met Arg 
        835                 840                 845             


Tyr His Glu Arg Thr Ser Glu Glu Met Arg Ala Leu Ala Ala Arg Tyr 
    850                 855                 860                 


Thr Thr Ile Gln Leu Pro Asp Gly Leu Phe Thr Pro Tyr Ile Leu Glu 
865                 870                 875                 880 


Ile Leu Gln Lys His Tyr Thr Glu Asn Ser Asp Leu Gln Asn Ala Leu 
                885                 890                 895     


Ser Gln Asp Val Pro Val Lys Leu Asn Pro Thr Cys Asn Ala Ala Tyr 
            900                 905                 910         


Leu Ile Thr Leu Phe Tyr Gln Thr Val Leu Lys Asp Asn Ala Gln Pro 
        915                 920                 925             


Phe Tyr Leu Ser Asp Lys Thr Tyr Thr Arg Asn Lys Asp Gly Glu Lys 
    930                 935                 940                 


Ala Glu Ser Phe Ser Phe Lys Arg Ala Tyr Glu Leu Phe Ser Val Leu 
945                 950                 955                 960 


Asn Asn Asn Lys Lys Asp Thr Phe Pro Phe Glu Met Ile Pro Leu Phe 
                965                 970                 975     


Leu Thr Ser Asp Glu Ile Gln Glu Arg Leu Ser Ala Lys Leu Leu Asp 
            980                 985                 990         


Gly Asp Gly Asn Pro Val Pro Glu  Val Gly Glu Lys Gly  Lys Pro Ala 
        995                 1000                 1005             


Thr Asp  Ser Gln Gly Asn Thr  Ile Trp Lys Arg Arg  Ile Tyr Ser 
    1010                 1015                 1020             


Glu Val  Asp Asp Tyr Ala Glu  Lys Leu Thr Asp Arg  Asp Met Lys 
    1025                 1030                 1035             


Ile Ser  Phe Lys Gly Glu Trp  Glu Lys Leu Pro Arg  Trp Lys Gln 
    1040                 1045                 1050             


Asp Lys  Ile Ile Lys Arg Arg  Asp Glu Thr Arg Leu  Gln Met Arg 
    1055                 1060                 1065             


Asp Glu  Leu Leu Gln Arg Met  Pro Arg Tyr Ile Arg  Asp Ile Lys 
    1070                 1075                 1080             


Asp Asn  Glu Arg Thr Leu Arg  Arg Tyr Lys Thr Gln  Asp Met Val 
    1085                 1090                 1095             


Leu Phe  Leu Leu Ala Glu Lys  Met Phe Thr Asn Ile  Ile Ser Glu 
    1100                 1105                 1110             


Gln Ser  Ser Glu Phe Asn Trp  Lys Gln Met Arg Leu  Ser Lys Val 
    1115                 1120                 1125             


Cys Asn  Glu Ala Phe Leu Arg  Gln Thr Leu Thr Phe  
    1130                 1135                 1140 


<210>  2551
<211>  1085
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2551

Met Lys Lys Glu Leu Asn Arg Glu Asp Val Phe Thr Gly Gly Lys Thr 
1               5                   10                  15      


Pro Glu Leu Thr Ile Tyr Tyr Asn Ile Ala Tyr Phe Arg Met Ala Gly 
            20                  25                  30          


Leu Ile Asn Ala Leu Cys Gly Asn Lys Leu Glu Arg Asp Lys Asp Ala 
        35                  40                  45              


Leu Glu Gln Phe Met Lys Ala Phe Ile Asn Gly Lys Gln Lys Leu Thr 
    50                  55                  60                  


Asp Met Gln Phe Val Lys Leu Cys Asp Tyr Leu Trp Lys Gly Tyr Lys 
65                  70                  75                  80  


Tyr Asp Lys Asn Arg Ser Glu Tyr Ser Leu Thr Glu Asn Asp Lys Thr 
                85                  90                  95      


Met Val Leu Lys Met Val Ala Lys Leu Gln Asp Ile Arg Asn Phe Gln 
            100                 105                 110         


Ser His Ile Trp His Asp Asn Lys Val Leu Val Phe Asp Ala Asp Leu 
        115                 120                 125             


Val Gln Phe Ile Lys Asn Lys His Leu Glu Ala Ile Asp Ala Gln Arg 
    130                 135                 140                 


Gln Arg Phe Ser Lys Glu Thr Glu Val Tyr Glu Lys Glu Asn Arg Glu 
145                 150                 155                 160 


Leu Lys Lys Lys Lys Asn Lys Glu Leu Leu Phe Asp Ile His Asp Gly 
                165                 170                 175     


Leu Gly Tyr Ile Thr Gly Glu Gly Arg Asn Phe Phe Leu Ser Phe Phe 
            180                 185                 190         


Leu Thr Arg Gly Glu Met Thr Arg Phe Leu Lys Gln Arg Lys Gly Cys 
        195                 200                 205             


Lys Arg Asp Asp Thr Pro Glu Tyr Lys Ile Lys His Leu Val Tyr Arg 
    210                 215                 220                 


His Phe Thr His Arg Asp Gly Ala Thr Arg Thr His Tyr Gly Tyr Glu 
225                 230                 235                 240 


Asp Asn Met Leu Asp Gln Leu Pro Asp Lys Gln Glu Phe Leu Thr Thr 
                245                 250                 255     


Arg His Thr Tyr Arg Leu Ile Asn Tyr Leu Asn Asp Ile Pro Glu Glu 
            260                 265                 270         


Val Thr Asn Pro Glu Leu Phe Pro Leu Phe Asn Thr Ile Ser Asn Gly 
        275                 280                 285             


Ile Leu Ile Lys Glu Ser Val Gly Thr Tyr Ile Ala Phe Ile Asn Lys 
    290                 295                 300                 


Met Pro Leu Leu Ser Asp Phe Glu Phe Ser Glu Val Trp Gly Lys Asp 
305                 310                 315                 320 


Gly Lys Pro Tyr Thr Asn Leu Val Glu Phe Tyr His Lys Thr Gln Pro 
                325                 330                 335     


Gly Phe Lys Phe Arg Thr Asp Leu Asn Ser Phe His Lys Ile Ile Leu 
            340                 345                 350         


Asn Leu Ile Arg Asp Glu Asn Tyr Thr Gly Phe Phe Thr Thr Gln Leu 
        355                 360                 365             


Asn Leu Phe Met Ala His Arg Glu Glu Leu Ile Leu Val Ile Ser Lys 
    370                 375                 380                 


Pro Leu Ile Thr Pro Asn Asp Leu Leu Leu Ile Glu Glu His Tyr Arg 
385                 390                 395                 400 


Tyr Lys Leu Lys Ala Asn Asp Phe Val Arg Glu Lys Leu Gly Glu Trp 
                405                 410                 415     


Lys Glu Lys Ile Glu Lys Gly Lys Trp Glu Lys Ala Asn Glu Gln Lys 
            420                 425                 430         


Asp Lys Leu Ile Asn Leu Leu Gly Gly Val Ile Glu Ile Thr Phe Tyr 
        435                 440                 445             


Asp Phe Tyr Trp Gln Lys Asp Glu Lys Pro Arg Asn Glu Asn Arg Phe 
    450                 455                 460                 


Met Glu Phe Ala Ile Arg Phe Met Ala Asp Phe Asn Leu Leu Pro Asp 
465                 470                 475                 480 


Cys Glu Trp Glu Val Glu Pro Leu Gln Ile Glu Asn Asp Leu Ile Ala 
                485                 490                 495     


Asn Arg Thr Ala Thr Pro Asp Leu Lys Lys Ser Gly Ser Gln Phe Met 
            500                 505                 510         


Asn Gln Leu Thr Asp Asn Tyr Arg Leu Lys Phe Asn Asp Gly Gln Ile 
        515                 520                 525             


Ala Phe Arg Tyr Gln Asn Gln Val Phe Ile Met Gly His Lys Ala Val 
    530                 535                 540                 


Lys Asn Leu Leu Ile Ala Cys Phe Asp Gly Lys Glu Lys Met Leu Asn 
545                 550                 555                 560 


Gly Phe Met Pro Ala Leu Leu Ala Asp Leu Lys Lys Ile Thr Asn Glu 
                565                 570                 575     


His Ile Leu Lys Asn His Gln Ala Leu Asn Thr Leu Ser Leu Leu Asn 
            580                 585                 590         


Asn Asp Ser Ile Pro Ser Tyr Ile Ser Arg Gln Trp Gly Glu Ala Glu 
        595                 600                 605             


Pro Ile Thr Asp Met Lys Lys Lys Ala Ile Ala Arg Met Asp Tyr Ile 
    610                 615                 620                 


Thr Gln Gln Phe Glu Ala Leu Ile Glu Asn His His Tyr Leu Asn Arg 
625                 630                 635                 640 


Ala Asp Lys Asn Arg Gln Ile Met Arg Cys Tyr Lys Phe Phe Glu Trp 
                645                 650                 655     


Gln Tyr Pro Gln Asn Ser Gln Phe Lys Phe Leu Arg Arg Asn Glu Tyr 
            660                 665                 670         


His Arg Met Ser Ile Tyr His Tyr Cys Leu Asp Lys Glu Gln His Lys 
        675                 680                 685             


Tyr Asp Lys Lys Gly His Asn Tyr Leu Tyr Asn Arg Leu Ile Lys Glu 
    690                 695                 700                 


Ser His Asn Glu Ser Gly Asn Ile Glu Gln His Leu Pro Tyr Gln Ile 
705                 710                 715                 720 


Arg Thr Met Leu Asn Asp Ala Lys Asp Phe Asn Asp Tyr Phe Leu Arg 
                725                 730                 735     


Ile Leu Asn Ala Thr His Lys Ile Leu Thr Asp Trp Lys Asn Gln Leu 
            740                 745                 750         


Lys Gln Gly Arg Glu Pro Asn Asn Tyr Tyr Leu Ser Arg Leu Gly Phe 
        755                 760                 765             


Thr Gly Gly Leu Thr Gln Lys Val Val His Thr Arg Leu Leu Pro Phe 
    770                 775                 780                 


Ser Ile His Pro Gly Ile Pro Val Ser Phe Phe Tyr Arg Thr Glu Met 
785                 790                 795                 800 


Asn Gln Asn Pro Ser Phe Asn Leu Ser Ala Lys Val Trp Asn Ser Glu 
                805                 810                 815     


Ser Pro Phe Arg Val Gly Leu Lys Glu Ser Asn Tyr Gln Tyr Ala Lys 
            820                 825                 830         


Tyr Leu Gly Leu Phe Asn Glu Ile Lys Thr Gln Arg Lys Ile Ile Gly 
        835                 840                 845             


Lys Met Asn Gln Leu Ile Ala Glu Asp Ala Leu Leu Trp Gln Ile Ala 
    850                 855                 860                 


Lys Lys Tyr Leu Asp Lys Cys His Pro Lys Phe Ser Glu Ile Ile Asn 
865                 870                 875                 880 


Gln Gln Val Asn Gly Lys Gln Pro Leu Asn Val Lys Ala Ile His Asp 
                885                 890                 895     


Thr Glu Leu Thr Ile Asp Phe Pro Val Asp Lys Asn Leu Tyr Gln Val 
            900                 905                 910         


Val Val Lys Met Lys Gln Leu Asp Asp Phe Met Phe Ile Asp Ser Lys 
        915                 920                 925             


Pro Val Leu Glu Lys Thr Ile Arg Tyr Met Ile Lys Asn Ser Leu Arg 
    930                 935                 940                 


Asp Lys Glu Tyr Gln Gln Arg Val Phe Ile Glu Thr Asn Pro Gly Val 
945                 950                 955                 960 


Phe Lys Ile Pro Tyr Asn Glu Val Val Glu Ala Met Arg Thr Ile Asn 
                965                 970                 975     


His Gln Ala Leu Thr Trp Ala Arg Leu Leu Leu Asp Trp Glu Ser Lys 
            980                 985                 990         


Thr Val Lys Thr Ile Pro Glu Ala  Asp Lys Lys Ala Lys  Leu Gln Glu 
        995                 1000                 1005             


Ala Tyr  Asn Lys Arg Gln Pro  Ala Phe Phe Asn Phe  Asn Asp Ile 
    1010                 1015                 1020             


Cys Arg  Tyr Ala Asp Asp Gly  Lys Gln Leu Lys Asp  Leu Arg Asn 
    1025                 1030                 1035             


Lys Thr  Phe His Thr Glu Val  Pro Glu Thr Trp Thr  Tyr Asp Glu 
    1040                 1045                 1050             


Met Arg  Glu Asn Lys Thr Ile  Lys Met Val Leu Gly  Ile Asn Glu 
    1055                 1060                 1065             


Thr Thr  Phe Leu Lys Lys Asp  Tyr Ala Ile Glu Asn  Ala Arg Thr 
    1070                 1075                 1080             


Ile Glu  
    1085 


<210>  2552
<211>  1145
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2552

Met Glu Thr Leu Thr Ile Pro Glu Val Ile Lys Cys Arg Thr Leu Ser 
1               5                   10                  15      


Asp Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Ile Ala Lys Glu Phe Asp Leu Pro Leu 
        35                  40                  45              


Leu Ala Glu Glu Gly His Leu Lys Asn Ser Phe Leu Cys Lys Lys Glu 
    50                  55                  60                  


His Asn Lys Val Asn Trp Asn His Val Tyr Ser Arg Thr Lys Arg Phe 
65                  70                  75                  80  


Leu Ala Val Leu Lys Val Phe Asp Ala Glu Thr Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Lys Thr Ile Asn Trp Glu Gly Lys Asp Phe Ala Ser Met Ser Asp 
            100                 105                 110         


Ile Leu Lys Ile Val Phe Gly Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Thr Ile Arg Lys Thr Ala Val 
    130                 135                 140                 


Ser Ala Glu Met Ala Leu Phe Leu Thr Thr Asn Phe Arg Arg Ala Ile 
145                 150                 155                 160 


Glu Tyr Thr Lys Glu Arg Phe Lys Gly Val Leu Asn Asp Glu Asp Tyr 
                165                 170                 175     


Gln Leu Val Ala Ser Lys Lys Val Leu Glu Ala Asn Ser Thr Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Arg Phe Ile Gly Ile Ile Thr Gly Leu Lys Gly Thr Gln Asn 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro His Asp Arg Phe Gln Ser Asp Asn Pro Arg Gln Ala Phe Ser 
                245                 250                 255     


Leu Asp Leu Ile Asn Glu Leu Asn Arg Cys Pro Lys Val Leu Tyr Asn 
            260                 265                 270         


Ala Ile Thr Glu Glu Gly Lys Gln Lys Leu Arg Ser Ile Pro Gly Glu 
        275                 280                 285             


Leu Glu Asn Lys Asn Leu His Asp Asn Asn Thr Lys Lys Glu Ala Lys 
    290                 295                 300                 


Ile Glu Ala Glu Ala Tyr Glu Leu Tyr Ile Glu Ser Leu Thr Arg Gln 
305                 310                 315                 320 


Ile Arg Tyr Ser Asn Arg Phe Pro Asp Phe Ala Leu Lys Phe Ile Asp 
                325                 330                 335     


Glu Thr Asp Ile Phe Ser Glu Phe Arg Phe Gln Ile Asp Leu Gly Lys 
            340                 345                 350         


Leu Leu Val Asp Glu Tyr Leu Lys Phe Phe Asn Gly Glu His Val Gln 
        355                 360                 365             


Arg Arg Ile Val Glu Asn Ala Lys Ala Phe Gly Lys Leu Ile Asp Phe 
    370                 375                 380                 


Asn Asp Glu Ala Lys Val Met Thr Arg Ile Gly Asn Gly His Phe Ser 
385                 390                 395                 400 


Lys Arg Phe Glu Gln Phe Ala Pro Phe Tyr Asn Thr Glu Asp Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Arg His His Val Thr Ala Lys Leu Gly Pro Asp Ser 
            420                 425                 430         


Lys Gly Glu Pro Glu Lys Lys Leu Leu Gln Pro Leu Pro Glu Ala Phe 
        435                 440                 445             


Leu Ser Leu His Glu Leu Pro Lys Val Ile Leu Leu Asp Tyr Leu Gln 
    450                 455                 460                 


Lys Gly Glu Pro Glu Lys Leu Ile Asn Asp Phe Ile Leu Ile Asn Asn 
465                 470                 475                 480 


Ser Lys Leu Met Asn Met Ser Phe Ile Glu Ala Val Lys Thr Gln Leu 
                485                 490                 495     


Pro Pro Glu Trp Asp Glu Phe Gln Arg Arg Thr Gly Ser Lys Asn Glu 
            500                 505                 510         


Met Pro Tyr Asn Glu Lys Thr Leu Ala Tyr Leu Leu Gln Arg Lys Gln 
        515                 520                 525             


Ile Leu Asn Lys Ile Leu Ala Glu Phe Gln Leu Asn Asp Lys Gln Ile 
    530                 535                 540                 


Pro Gly Arg Ile Leu Asp Tyr Trp Leu Asn Ile Ala Asp Val Glu Glu 
545                 550                 555                 560 


Glu Arg Ala Val Ser Asp Arg Ile Lys Ser Ile Lys Arg Asp Cys Met 
                565                 570                 575     


Ser Arg Leu Arg Ala Leu Gly Lys Phe Lys Ile Asp Arg Asn Arg Asn 
            580                 585                 590         


Lys Ile Pro Lys Ile Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile 
        595                 600                 605             


Val Asp Met Val Val Ser Glu Gly Lys Lys His Lys Ile Thr Ser Phe 
    610                 615                 620                 


Tyr Tyr Glu Lys Met Gln Asp Cys Leu Ser Leu Phe Ala Asp Pro Leu 
625                 630                 635                 640 


Lys Arg Gln Leu Phe Ile His Ile Ile Thr Asn Glu Leu Arg Leu Asn 
                645                 650                 655     


Asp Ser Gly Gly His Pro Phe Leu Phe Lys Leu Asn Met Arg Gln Ile 
            660                 665                 670         


Asn Cys Thr Ser Asp Phe Tyr Glu Ile Tyr Leu Gln Glu Lys Gly His 
        675                 680                 685             


Lys Met Val Pro Glu Lys Asn Leu Lys Thr Gly Lys Val Val Asn Thr 
    690                 695                 700                 


Asp His Ser Trp Met Ala Leu Thr Phe Tyr Lys Leu Glu Phe Asn Asp 
705                 710                 715                 720 


Lys Val Asp Lys Leu Met Thr Val Val Lys Leu Pro Leu Asn Lys Leu 
                725                 730                 735     


Asn Leu Pro Phe Thr Leu Arg Gln Leu Asn Ala Lys Thr Thr Tyr Thr 
            740                 745                 750         


Leu Glu Gln Trp Leu Lys Asn Leu Thr Leu Gly Lys Lys Pro Asp Asp 
        755                 760                 765             


Gly Lys His Pro Val Asn Leu Pro Thr Asn Leu Phe Asp Glu Lys Leu 
    770                 775                 780                 


Ser Asp Leu Leu Arg Gln Asp Leu Asp Asn Asn Lys Ile Ala Tyr Arg 
785                 790                 795                 800 


Pro Tyr Ala Asn Trp Asn Glu Leu Phe Lys Ile Trp Trp Ile Ser Arg 
                805                 810                 815     


Asn Asp Ser Leu Gln Arg Phe Tyr Asn Ala Glu Arg Glu Tyr His Ile 
            820                 825                 830         


Phe Asn Glu Lys Val Asn Phe Tyr Pro Asn Arg Lys Glu Asn Phe Ala 
        835                 840                 845             


Asp Tyr Tyr Gln His Ala Val Lys Val Ala Phe Gln Lys Lys Arg Asn 
    850                 855                 860                 


Glu Arg Ile Ile Glu Gln Arg Ile Asn Lys Tyr Leu Pro Asp Ile Leu 
865                 870                 875                 880 


Phe Glu Gln Val Glu Lys Thr Phe Lys His Thr Ile Ala Glu Thr Glu 
                885                 890                 895     


Lys Glu Ile Arg Ile Leu Gln Glu Glu Asp Arg Ile Met Leu Leu Met 
            900                 905                 910         


Leu Glu Gly Leu Met Glu Asp Gly Asn Lys Gln Gln Leu Lys Leu Ser 
        915                 920                 925             


Glu Ile Lys Thr Leu Gln Asn Ala Thr Ile Asn Ile Arg Gln Leu Val 
    930                 935                 940                 


Pro Gly Lys Leu Ser Phe Asp Asp Ser Gly Glu Ala Ile Lys Asp Ser 
945                 950                 955                 960 


Thr Asn Pro Glu Ile Val Arg Thr Val Ser Val Ser Ile Lys Arg Ile 
                965                 970                 975     


Glu Tyr Asn Leu Leu Pro Lys Tyr Val Ala Asp Gly Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Pro Asp Glu  Glu Ile Gln Met Glu  Arg Leu Lys 
        995                 1000                 1005             


Thr Glu  Phe Asp Thr Tyr Asn  Lys Val Arg Gln Val  Val Leu Asp 
    1010                 1015                 1020             


Leu Ser  Phe Lys Leu Glu Lys  Met Ile Ile Glu Lys  Gly His Lys 
    1025                 1030                 1035             


Asp Arg  Ile Asn Gln Leu Cys  Thr Gly Ala Thr Gly  Glu Leu Leu 
    1040                 1045                 1050             


Thr Gly  Asn Ile Cys His His  Thr Tyr Leu Thr Trp  Leu Lys Asp 
    1055                 1060                 1065             


Lys Glu  Met Ile Asp Asn Glu  Thr Phe Ile Phe Met  Asn Met Val 
    1070                 1075                 1080             


Gln His  Cys Phe Ser His Asn  Gln Tyr Pro Gln Lys  Lys Thr Met 
    1085                 1090                 1095             


Glu Arg  Ile Ile Asn His Trp  Glu Pro Asp Arg Phe  Ala Leu Thr 
    1100                 1105                 1110             


Ile Ala  Ala Thr Tyr Asn Gln  Lys Ile Ala Gly Ile  Leu Glu Asp 
    1115                 1120                 1125             


Ile Gly  Thr Phe Pro Phe Ile  Arg Ser Arg Lys Thr  Met Pro Asp 
    1130                 1135                 1140             


Val Val  
    1145 


<210>  2553
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2553

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2554
<211>  1097
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2554

Met Glu Tyr Thr Arg Tyr Lys Glu Trp Gly Lys Asp Leu Phe Tyr Phe 
1               5                   10                  15      


Asn His Phe Ala Asn Met Ala Arg His Asn Ala Phe Leu Ile Ile Asn 
            20                  25                  30          


Asp Ile Leu Asn Thr Val Tyr Lys Ala Glu Asp Gln Leu Thr Glu Glu 
        35                  40                  45              


Ser Leu Ser Asn Leu Tyr Lys Lys Val Leu Ala Lys Ser Lys Gly Arg 
    50                  55                  60                  


Pro Asp Glu Leu Ala Leu Leu Ser Ser Leu Leu Lys Lys His Phe Pro 
65                  70                  75                  80  


Phe Leu His Tyr Tyr Asp Asn Val Gln Ser Asp Glu Ile Ala Pro Tyr 
                85                  90                  95      


Leu Asn Ser Ile Lys Asp Leu Asn Ile Tyr Ser Asn Lys Pro Glu Glu 
            100                 105                 110         


Val Pro Lys Asp Asp Asp Pro Gly Met Cys Ile Trp Trp Leu Ser Tyr 
        115                 120                 125             


Val Phe Leu Pro Ile Leu Asn Arg Leu Arg Asn Glu Thr Ala His Tyr 
    130                 135                 140                 


Gly His Thr Lys Leu Gly Gly Asp Ile Pro Phe Leu Glu Gln Ser Phe 
145                 150                 155                 160 


Asn Glu Thr Ile Lys Glu Ala Gln Lys Arg Met Asn Tyr Ser His Glu 
                165                 170                 175     


Asp Val Glu His Leu Leu Arg Thr Asp Ser Tyr Tyr Lys Pro Leu Ser 
            180                 185                 190         


Ile Asn Lys Ser Leu Ser Glu Lys Gly Ile Phe Tyr Leu Tyr Cys Leu 
        195                 200                 205             


Phe Leu Asp Lys Lys Asn Gly Tyr Gln Phe Leu Ser His Ile Lys Gly 
    210                 215                 220                 


Phe Lys Asp Arg Arg Glu Thr Ala Lys Lys Ala Thr Thr Glu Val Phe 
225                 230                 235                 240 


Thr His Asn His Cys Arg Leu Pro Tyr Pro Lys Leu Asp Ser Ser Asp 
                245                 250                 255     


Leu Ala Leu Asp Ile Leu Asn Glu Leu Asn Arg Cys Pro Gly Ala Leu 
            260                 265                 270         


Tyr Ser Val Leu Ser Asp Asp Asp Arg Lys Lys Phe Val Thr Thr Leu 
        275                 280                 285             


Pro Thr Ala Glu Glu Gly Asp Glu Val Met Glu Ser Val Met Lys Arg 
    290                 295                 300                 


Gly Lys Glu Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Leu Glu Gln 
305                 310                 315                 320 


Glu Gly Val Leu Arg Gly Ile Ser Phe Gln Leu Phe Leu Gly Arg Phe 
                325                 330                 335     


Glu Gln Lys Glu Ala His His Lys Ile Val Gly Gln Glu Met Arg Glu 
            340                 345                 350         


His Lys Leu Leu Lys Asn Ile His Thr Phe Gly Gln Leu Glu Arg Phe 
        355                 360                 365             


Lys Thr Glu Ala Ala Asn Asn Phe Phe Leu Asn Glu Lys Lys Gly Ile 
    370                 375                 380                 


Val Glu Phe Tyr Ala Pro Ala Tyr Arg Met Val Gly Asn Arg Ile Gly 
385                 390                 395                 400 


Leu Ile Leu Lys Asp Ala Asn Ile Asn Asp Thr Gly Phe Glu Glu Val 
                405                 410                 415     


Leu Asp Asn Tyr Lys Leu Pro Leu Glu Glu Arg Asn Cys Pro Asp Ala 
            420                 425                 430         


Ile Met Ser Thr His Glu Leu Thr Ala Leu Phe Phe Tyr Asn Tyr Leu 
        435                 440                 445             


His Arg Glu Gly Ile Ile Arg Thr Ser Pro Lys Glu His Ile Leu Ser 
    450                 455                 460                 


Phe Leu Gln Asn Phe Lys Arg Phe Arg Glu Asp Leu Lys Lys Gly Lys 
465                 470                 475                 480 


Leu Lys Pro Ile Pro Gly Glu His Lys Leu Tyr Lys Met Lys Cys His 
                485                 490                 495     


Lys Gln Gly Ser Ser Asn Glu Leu Asn Arg Lys Arg Ile Leu Leu Gln 
            500                 505                 510         


Glu Ile Leu Asn Glu Tyr Gly Leu Lys Val Ala Trp Leu Pro Asp Ala 
        515                 520                 525             


Cys Arg Glu Tyr Leu Leu Gly Tyr Thr Ser Ser Asp Asn Thr His Ile 
    530                 535                 540                 


Ile Lys Gln Glu Phe Leu Lys Met Leu Asn Ser Ser Lys Ser Arg Arg 
545                 550                 555                 560 


Asp Lys Ile Ile Ala Phe Asn Lys Ser Ile Ser Glu Tyr Lys Lys Arg 
                565                 570                 575     


Asn Glu Ile Lys Leu Thr Gln Ala Lys Leu Glu Ile Arg Thr Gly Glu 
            580                 585                 590         


Leu Ala Thr Gln Leu Ala Arg Asp Ile Ile Tyr Met Thr Ser Pro Met 
        595                 600                 605             


Asn Lys Glu Gly Lys Ser Lys Lys Met Asn Asp Leu Glu Tyr Asn Val 
    610                 615                 620                 


Leu Gln Ser Met Leu Ala Tyr Phe Pro Leu His Lys Asn Glu Leu Thr 
625                 630                 635                 640 


Ala Tyr Leu Gly Ile Leu Lys Glu Gly Lys Val Trp Lys His Pro Phe 
                645                 650                 655     


Leu Glu Asp Val Leu Lys Glu Leu His Ser Ala Gln Ser Leu Ala Asp 
            660                 665                 670         


Phe Tyr Ser Leu Tyr Tyr Asp Ala Lys Ile Asp Trp Ile Asn His Lys 
        675                 680                 685             


Ile Ile Lys Glu Gln Val Glu His Asp Asn Asn Lys Lys Lys Tyr Ser 
    690                 695                 700                 


Trp Thr Leu Arg Val Gly Ala Glu Lys Met Val Thr Glu Gln Tyr Ala 
705                 710                 715                 720 


Tyr Leu Leu Asn Leu Glu Lys Lys Thr Lys Thr Ala Pro Gln Lys Glu 
                725                 730                 735     


Tyr Ala Asp Lys Ala Val Phe Leu Pro Thr Gly Leu Phe Asp Glu Ala 
            740                 745                 750         


Ile Ser Lys Ser Leu Ile Asp Lys Gly Tyr Glu Leu Arg Glu Asn Ser 
        755                 760                 765             


Asn Thr Ala Gly Cys Leu Lys Val Tyr Leu Asn Lys Glu Thr Gln Pro 
    770                 775                 780                 


Met Tyr Ser Glu Leu Lys Arg Tyr Tyr Arg Tyr Val Thr Gly Arg Gly 
785                 790                 795                 800 


Pro Arg Leu Thr Gly Arg Met Met Glu Arg Glu Glu Ala Lys Asn Phe 
                805                 810                 815     


Leu Ser His Asn Phe Ala Asn Ser Ser Leu Gln Pro Met Lys Lys Glu 
            820                 825                 830         


Ser Leu Lys Gln Phe Gly Lys Lys Ile Lys Glu Lys Glu Ala Glu Ile 
        835                 840                 845             


Leu Arg Gln Gln Asn Asn Asp Arg Ala Leu Phe Leu Met Leu Tyr Ala 
    850                 855                 860                 


Met Pro Asp Ala Asn Gly Val Ser Arg Ile Val Lys Glu Lys Thr Gly 
865                 870                 875                 880 


Leu Cys Lys Leu Gly Phe Asp Leu Asn Asp Asn Leu Leu Asn Thr Glu 
                885                 890                 895     


Tyr Thr Val Lys Gln Thr Leu Val Arg Met Val Asn Asn Val Arg Val 
            900                 905                 910         


Glu Arg Val Val Thr Ala Thr Leu Pro Val Lys Arg Tyr Gly Glu Met 
        915                 920                 925             


Arg Arg Phe Leu Lys Asp Arg Arg Ile Asp Gly Leu Leu Leu Tyr Tyr 
    930                 935                 940                 


Pro Glu Gly Lys Glu Ile Pro Leu Gly Thr Leu Glu Ser Ser Lys Thr 
945                 950                 955                 960 


Ala Leu Lys Gly Glu Lys Tyr Ser Tyr Ser Asn Leu Ile Asp Glu Leu 
                965                 970                 975     


Asp Val Tyr Asp Arg Lys Arg Asn Glu Leu Met Glu Arg Ile Tyr Glu 
            980                 985                 990         


Val Asp Arg Leu Met Ala Val Asn  Phe Pro Leu Ile Lys  Lys Lys Thr 
        995                 1000                 1005             


Lys Gly  Asn Ala Ser Tyr Tyr  Glu His Tyr Asp Cys  Leu Asp Tyr 
    1010                 1015                 1020             


Ala Arg  Thr Asn Leu Gly Leu  Ala Asn Gln Val Ser  Leu Leu Gln 
    1025                 1030                 1035             


Arg Glu  Arg Ile Thr Leu Leu  Arg Ser Lys Leu Ala  His Asn Gln 
    1040                 1045                 1050             


Ile Pro  Tyr Glu Ala Trp Ile  Cys Glu Glu Ile Glu  Lys Met Asp 
    1055                 1060                 1065             


Asp Pro  Leu Ile Thr Ser Arg  Ile Ile Asn Leu Val  Ala Ser Cys 
    1070                 1075                 1080             


Tyr Glu  Glu Leu Leu Leu Ser  Ile Lys Lys Lys Ile  Lys Glu 
    1085                 1090                 1095         


<210>  2555
<211>  1113
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2555

Met Glu Asp Asp Lys Lys Thr Thr Asp Ser Ile Ser Tyr Glu Leu Lys 
1               5                   10                  15      


Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val 
            20                  25                  30          


Tyr Ile Thr Val Asn His Ile Asn Lys Ile Leu Glu Glu Asp Glu Ile 
        35                  40                  45              


Asn Arg Asp Gly Tyr Glu Asn Thr Leu Glu Asn Ser Trp Asn Glu Ile 
    50                  55                  60                  


Lys Asp Ile Asn Lys Lys Asp Arg Leu Ser Lys Leu Ile Ile Lys His 
65                  70                  75                  80  


Phe Pro Phe Leu Glu Ala Ala Thr Tyr Arg Gln Asn Pro Thr Asp Thr 
                85                  90                  95      


Thr Lys Gln Lys Glu Glu Lys Gln Ala Glu Ala Gln Ser Leu Glu Ser 
            100                 105                 110         


Leu Lys Lys Ser Phe Phe Val Phe Ile Tyr Lys Leu Arg Asp Leu Arg 
        115                 120                 125             


Asn His Tyr Ser His Tyr Lys His Ser Lys Ser Leu Glu Arg Pro Lys 
    130                 135                 140                 


Phe Glu Glu Asp Leu Gln Asn Lys Met Tyr Asn Ile Phe Asp Val Ser 
145                 150                 155                 160 


Ile Gln Phe Val Lys Glu Asp Tyr Lys His Asn Thr Asp Ile Asn Pro 
                165                 170                 175     


Lys Lys Asp Phe Lys His Leu Asp Arg Lys Arg Lys Gly Lys Phe His 
            180                 185                 190         


Tyr Ser Phe Ala Asp Asn Glu Gly Asn Ile Thr Glu Ser Gly Leu Leu 
        195                 200                 205             


Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Val Gln 
    210                 215                 220                 


Lys Lys Leu Glu Gly Phe Lys Cys Ser Asn Glu Ser Tyr Gln Lys Met 
225                 230                 235                 240 


Thr Asn Glu Val Phe Cys Arg Ser Arg Met Leu Leu Pro Lys Leu Arg 
                245                 250                 255     


Leu Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu Asn 
            260                 265                 270         


Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Arg Gly Glu 
        275                 280                 285             


Asp Arg Glu Lys Phe Arg Val Pro Ile Glu Ile Ala Asp Glu Asp Tyr 
    290                 295                 300                 


Asp Ala Glu Gln Glu Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp 
305                 310                 315                 320 


Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Tyr Asn Glu Ile Phe 
                325                 330                 335     


Thr Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile 
            340                 345                 350         


Tyr Lys Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg His Leu Thr His 
        355                 360                 365             


Lys Leu Tyr Gly Phe Glu Arg Ile Gln Glu Phe Asn Lys Gln Asn Arg 
    370                 375                 380                 


Pro Asp Glu Trp Lys Ala Leu Val Lys Asp Leu Asp Thr Tyr Glu Thr 
385                 390                 395                 400 


Ser Glu Glu Pro Tyr Ile Ser Glu Thr Thr Pro His Tyr His Leu Glu 
                405                 410                 415     


Asn Gln Lys Ile Gly Ile Arg Phe Arg Asn Gly Asn Asn Asp Ile Trp 
            420                 425                 430         


Ala Ser Leu Glu Thr Asn Gly Glu Asn Asn Glu Lys Ser Lys Tyr Lys 
        435                 440                 445             


Leu Asp Lys Gln Tyr Gln Ala Glu Ala Phe Leu Ser Val His Glu Leu 
    450                 455                 460                 


Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Lys Lys Glu Lys Pro Asn 
465                 470                 475                 480 


Asn Asp Glu Ile Asn Ala Ser Ile Val Glu Gly Phe Ile Lys Arg Glu 
                485                 490                 495     


Ile Arg Tyr Met Tyr Lys Leu Tyr Asp Ala Phe Ala Asn Gly Glu Ile 
            500                 505                 510         


Asn Asn Ile Asp Asp Leu Glu Lys Tyr Cys Glu Asp Lys Gly Ile Pro 
        515                 520                 525             


Lys Arg His Leu Pro Lys Gln Met Val Ala Ile Leu Tyr Asp Glu His 
    530                 535                 540                 


Lys Asp Met Val Glu Glu Ala Lys Arg Lys Gln Lys Glu Met Val Lys 
545                 550                 555                 560 


Asp Thr Lys Lys Leu Leu Ala Thr Leu Glu Lys Gln Thr Gln Gly Glu 
                565                 570                 575     


Ile Glu Asp Gly Gly Arg Asn Ile Arg Leu Leu Lys Ser Gly Glu Ile 
            580                 585                 590         


Ala Arg Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln Lys 
        595                 600                 605             


Asp Asn Glu Gly Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu 
    610                 615                 620                 


Tyr Gln Met Leu Gln Arg Ser Leu Ala Leu Tyr Asn Lys Glu Glu Lys 
625                 630                 635                 640 


Pro Thr Arg Tyr Phe Ile Gln Val Asn Leu Ile Lys Ser Ser Asn Pro 
                645                 650                 655     


His Pro Phe Leu Glu Glu Thr Glu Trp Glu Lys Cys Asn Asn Ile Leu 
            660                 665                 670         


Ser Phe Tyr Arg Ser Tyr Leu Lys Ala Arg Lys Ser Phe Leu Glu Ser 
        675                 680                 685             


Leu Lys Pro Glu Asp Trp Glu Lys Asn Gln Tyr Phe Leu Met Leu Lys 
    690                 695                 700                 


Glu Pro Lys Thr Asn Arg Lys Thr Leu Val Gln Gly Trp Lys Asn Gly 
705                 710                 715                 720 


Phe Asn Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg Lys Trp Phe 
                725                 730                 735     


Met Glu His Trp Lys Asn Ile Lys Val Asp Asp Ser Lys Arg Val Gly 
            740                 745                 750         


Leu Val Ala Lys Val Ile Pro Leu Phe Phe Ser Glu Lys Tyr Lys Asp 
        755                 760                 765             


Ser Val Gln Pro Phe Tyr Asn Tyr Pro Phe Asn Val Gly Asp Val Asn 
    770                 775                 780                 


Lys Pro Lys Glu Glu Asp Phe Leu His Arg Glu Glu Arg Ile Glu Leu 
785                 790                 795                 800 


Trp Gly Lys Lys Lys Asp Lys Phe Lys Gly Tyr Lys Ala Lys Lys Lys 
                805                 810                 815     


Phe Lys Glu Met Thr Asp Lys Glu Lys Glu Glu His Arg Ser Tyr Leu 
            820                 825                 830         


Glu Phe Lys Ser Trp Asn Gln Phe Glu Arg Glu Leu Arg Leu Val Arg 
        835                 840                 845             


Asn Gln Asp Ile Val Thr Trp Leu Leu Cys Met Glu Leu Phe Asp Lys 
    850                 855                 860                 


Leu Lys Val Glu Gly Leu Asn Val Glu Glu Leu Lys Lys Leu Arg Leu 
865                 870                 875                 880 


Lys Asp Ile Asn Thr Asp Thr Ala Lys Lys Glu Lys Asn Asn Ile Leu 
                885                 890                 895     


Asn Arg Val Met Pro Met Glu Leu Pro Val Thr Val Tyr Glu Val Asn 
            900                 905                 910         


Lys Gly Gly Tyr Ile Ile Lys Asn Lys Pro Leu His Thr Ile Tyr Ile 
        915                 920                 925             


Lys Glu Ala Lys Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu 
    930                 935                 940                 


Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Val Lys Thr Pro 
945                 950                 955                 960 


Ser Glu Ala Glu Ser Glu Ser Asn Pro Ile Ser Lys Ser Arg Val Glu 
                965                 970                 975     


Ser Glu Leu Gly Lys Tyr Gln Asn Ala Arg Leu Asn Ile Ile Glu Asp 
            980                 985                 990         


Met Leu Ala Leu Glu Lys Thr Leu  Ile Asp Asn Tyr Asn  Ser Leu Asp 
        995                 1000                 1005             


Thr Asp  Asn Phe Ser Leu Asp  Thr Asp Asn Phe His  Asn Met Leu 
    1010                 1015                 1020             


Thr Gly  Trp Leu Glu Leu Lys  Gly Glu Ala Asn Lys  Ala Arg Phe 
    1025                 1030                 1035             


Gln Asn  Glu Val Asp Leu Leu  Val Ala Val Arg Asn  Ala Phe Ser 
    1040                 1045                 1050             


His Asn  Gln Tyr Pro Met Tyr  Asp Glu Asn Leu Phe  Val Asn Ile 
    1055                 1060                 1065             


Glu Arg  Phe Cys Leu Ser Ser  Ser Lys Ile Leu Glu  Ser Lys Gly 
    1070                 1075                 1080             


Leu Ser  Ile Ala Val Lys Leu  Lys Glu Glu Val Ser  Lys Ala Val 
    1085                 1090                 1095             


Glu Lys  Ile Gln Asn Glu Glu  Asp Asn Lys Lys Glu  Lys Glu Thr 
    1100                 1105                 1110             


<210>  2556
<211>  1119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2556

Met Glu Asp Asp Lys Lys Thr Thr Glu Ser Ile Ser Tyr Glu Leu Glu 
1               5                   10                  15      


Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val 
            20                  25                  30          


Tyr Ile Thr Ile Asn His Ile Asn Lys Leu Leu Glu Ile Arg Glu Ile 
        35                  40                  45              


Asp Asn Asp Glu Lys Val Leu Asp Ile Lys Ala Leu Trp Gln Lys Gly 
    50                  55                  60                  


Asn Lys Asp Leu Asn Gln Lys Ala Arg Leu Arg Glu Leu Met Thr Lys 
65                  70                  75                  80  


His Phe Pro Phe Leu Glu Thr Ala Ile Tyr Thr Lys Asn Lys Glu Asp 
                85                  90                  95      


Lys Glu Glu Val Lys Gln Glu Lys Gln Ala Lys Ala Gln Ser Phe Asp 
            100                 105                 110         


Ser Leu Lys His Cys Leu Phe Leu Phe Leu Glu Lys Leu Gln Glu Ala 
        115                 120                 125             


Arg Asn Tyr Tyr Ser His Tyr Lys Tyr Ser Glu Ser Thr Lys Glu Pro 
    130                 135                 140                 


Met Leu Glu Lys Glu Leu Leu Lys Lys Met Tyr Asn Ile Phe Asp Ala 
145                 150                 155                 160 


Asn Ile Gln Leu Val Ile Asn Asp Tyr Gln His Asn Lys Asp Ile Asp 
                165                 170                 175     


Pro Glu Glu Asp Phe Lys His Leu Asp Thr Ile Glu Asp Ser Ser Tyr 
            180                 185                 190         


Ser Phe Thr Val Lys Asp Asn Lys Glu Lys Ile Thr Ala Ser Gly Leu 
        195                 200                 205             


Leu Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Met 
    210                 215                 220                 


Gln Gln Lys Leu Arg Gly Phe Lys Asp Asn Arg Glu Ser Lys Lys Lys 
225                 230                 235                 240 


Met Thr His Glu Val Phe Cys Arg Ser Arg Met Leu Leu Pro Lys Leu 
                245                 250                 255     


Arg Leu Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu 
            260                 265                 270         


Asn Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Gln Gly 
        275                 280                 285             


Lys Tyr Arg Glu Lys Phe Lys Val Pro Phe Asp Pro Ala Asp Glu Asp 
    290                 295                 300                 


Tyr Asp Ala Glu Gln Glu Pro Phe Lys Asn Thr Leu Val Arg His Gln 
305                 310                 315                 320 


Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Tyr Asn Glu Ile 
                325                 330                 335     


Phe Thr Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser 
            340                 345                 350         


Ile Tyr Lys Lys Gln Ile Gly Gly Gln Lys Glu Asp Arg His Leu Thr 
        355                 360                 365             


His Lys Leu Tyr Gly Phe Glu Arg Ile Gln Glu Phe Asp Lys Gln Asn 
    370                 375                 380                 


Arg Thr Asp Glu Trp Lys Ala Leu Val Lys Asp Leu Asp Thr Tyr Glu 
385                 390                 395                 400 


Thr Ser Asn Glu Arg Tyr Ile Ser Glu Thr Thr Pro His Tyr His Leu 
                405                 410                 415     


Glu Asn Gln Lys Ile Gly Ile Arg Phe Arg Asn Gly Asn Asn Asp Ile 
            420                 425                 430         


Trp Pro Ser Leu Glu Thr Asn Gly Glu Asn Asn Glu Lys Ser Lys Tyr 
        435                 440                 445             


Lys Leu Asp Lys Pro Tyr Gln Ala Glu Ala Phe Leu Ser Val His Glu 
    450                 455                 460                 


Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Lys Lys Glu Lys Pro 
465                 470                 475                 480 


Asn Asn Asp Glu Ile Asn Ala Ser Ile Val Glu Gly Phe Ile Lys Arg 
                485                 490                 495     


Glu Ile Arg Asp Ile Tyr Lys Leu Tyr Asp Ala Phe Ala Asn Gly Glu 
            500                 505                 510         


Ile Asn Ser Glu Asp Asp Phe Lys Lys Tyr Cys Lys Gly Lys Asp Ile 
        515                 520                 525             


Glu Met Val His Leu Pro Lys Gln Met Val Ala Ile Leu Lys Asn Lys 
    530                 535                 540                 


Pro Lys Asp Val Ala Glu Glu Ala Lys His Lys Gln Lys Lys Met Val 
545                 550                 555                 560 


Lys Ala Ala Lys Arg Lys Gln Arg Lys Met Val Lys Asp Thr Glu Lys 
                565                 570                 575     


Leu Leu Ala Ala Leu Glu Glu Gln Thr Gln Gly Glu Ile Glu Asp Gly 
            580                 585                 590         


Gly Arg Asn Ile Arg Leu Leu Lys Ser Gly Glu Ile Ala Arg Trp Leu 
        595                 600                 605             


Val Asn Asp Met Met Arg Phe Gln Pro Val Gln Lys Asp Asn Glu Gly 
    610                 615                 620                 


Asn Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln Met Leu 
625                 630                 635                 640 


Gln Arg Ser Leu Ala Leu Tyr Asn Lys Glu Glu Lys Pro Thr Arg Tyr 
                645                 650                 655     


Phe Arg Gln Val Asn Leu Ile Asn Ser Ser Asn Pro His Pro Phe Leu 
            660                 665                 670         


Lys Trp Thr Lys Trp Glu Glu Cys Asn Asn Ile Leu Ser Phe Tyr Arg 
        675                 680                 685             


Ser Tyr Leu Thr Lys Lys Ile Glu Phe Leu Asn Lys Leu Lys Pro Glu 
    690                 695                 700                 


Asp Trp Glu Lys Asn Gln Tyr Phe Leu Lys Leu Lys Glu Pro Lys Thr 
705                 710                 715                 720 


Asn Arg Glu Thr Leu Val Gln Gly Trp Lys Asn Gly Phe Asn Leu Pro 
                725                 730                 735     


Arg Gly Ile Phe Thr Glu Pro Ile Arg Glu Trp Phe Lys Arg His Gln 
            740                 745                 750         


Asn Asp Ser Glu Glu Tyr Lys Lys Val Glu Ala Leu Lys Arg Val Gly 
        755                 760                 765             


Leu Val Ala Lys Val Ile Pro Leu Phe Phe Lys Glu Glu Tyr Phe Lys 
    770                 775                 780                 


Glu Asp Ala Gln Lys Glu Ile Asn Asn Cys Val Gln Pro Phe Tyr Gly 
785                 790                 795                 800 


Phe Pro Tyr Asn Val Gly Asn Ile His Lys Pro Asp Glu Lys Asp Phe 
                805                 810                 815     


Leu Leu Ser Glu Glu Arg Lys Lys Leu Trp Gly Asp Lys Lys Asn Lys 
            820                 825                 830         


Phe Lys Gly Tyr Lys Ala Lys Lys Lys Pro Lys Lys Ile Thr Asp Glu 
        835                 840                 845             


Val Lys Glu Glu Tyr Arg Ser Tyr Leu Glu Phe Gln Ser Trp Asn Lys 
    850                 855                 860                 


Phe Glu Arg Glu Leu Arg Leu Val Arg Asn Gln Asp Ile Val Thr Trp 
865                 870                 875                 880 


Leu Leu Cys Thr Glu Leu Ile Asp Lys Leu Lys Val Glu Gly Leu Asn 
                885                 890                 895     


Val Glu Glu Leu Lys Lys Leu Arg Leu Lys Asp Ile Asp Thr Asp Thr 
            900                 905                 910         


Ala Lys Gln Glu Lys Asn Asn Ile Leu Asn Arg Ile Met Pro Met Gln 
        915                 920                 925             


Leu Pro Val Thr Val Tyr Glu Ile Asp Asp Ser His Asn Ile Val Lys 
    930                 935                 940                 


Asp Arg Pro Leu His Thr Val Tyr Ile Glu Glu Thr Lys Thr Lys Leu 
945                 950                 955                 960 


Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys Asp Arg Arg Leu Asn 
                965                 970                 975     


Gly Leu Phe Ser Phe Val Asp Thr Ser Ser Glu Ala Glu Leu Lys Ser 
            980                 985                 990         


Asn Pro Ile Ser Lys Ser Leu Val  Glu Tyr Glu Leu Gly  Glu Tyr Gln 
        995                 1000                 1005             


Asn Ala  Arg Ile Glu Thr Ile  Lys Asp Met Leu Leu  Leu Glu Glu 
    1010                 1015                 1020             


Thr Leu  Ile Glu Lys Asp Lys  Asn Leu Pro Thr Asp  Asn Phe Ser 
    1025                 1030                 1035             


Asp Met  Leu Asn Gly Trp Leu  Glu Gly Lys Asp Glu  Ala Asp Lys 
    1040                 1045                 1050             


Ala Arg  Phe Gln Asn Asp Val  Lys Leu Leu Val Ala  Val Arg Asn 
    1055                 1060                 1065             


Ala Phe  Ser His Asn Gln Tyr  Pro Met Tyr Asn Ser  Glu Val Phe 
    1070                 1075                 1080             


Glu Gly  Ile Lys Leu Leu Asn  Pro Ser Ser Ala Glu  Phe Lys Asp 
    1085                 1090                 1095             


Lys Glu  Leu Gly Ile Ala Asn  Gln Leu Lys Lys Lys  Val Lys Glu 
    1100                 1105                 1110             


Ala Ile  Glu Lys Ile Asn 
    1115                 


<210>  2557
<211>  1094
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2557

Met Glu Ala Asn Glu Gln Asn Gln Glu Asn Arg Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Asn Asn His Ile Ala Ala Asp Phe Gly Gln Ala Val 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ser Gly Phe Leu Cys Asn Lys Glu 
    50                  55                  60                  


Ile Lys Lys Leu Asn Trp Asn His Ile Tyr Ala Lys Thr Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ile Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Val Asn Ser Asp Lys Glu Gly Lys Asp Phe Ala Ala Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Ser Glu Leu Gln Asp Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Glu Asn Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Ala Glu Leu Thr Asp Met Leu Thr Ile Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Thr Asp Ala Asp Tyr 
                165                 170                 175     


Glu Leu Val Glu Thr Lys Gln Val Val Thr Thr Gly Asn Ile Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Met Phe Leu Glu Arg Glu His 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asn Leu Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Gly 
            260                 265                 270         


Val Ile Thr Asp Glu Glu Lys Met Gln Phe Arg Pro Glu Leu Asp Glu 
        275                 280                 285             


Leu Asp Ile Glu Lys Leu Ile Ala Asn Ser Thr Asn Asp Asp Glu Arg 
    290                 295                 300                 


Glu Arg Ile Leu Asp Glu Ile Gly Tyr Glu Glu Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg Tyr Asn Asn Arg Phe Pro Tyr Phe Ala Met Arg 
                325                 330                 335     


Phe Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Arg Tyr Thr Lys Gln Leu Ala Gly Glu 
        355                 360                 365             


Gln Thr Glu Arg Val Val Gln Glu Asn Val Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asp Pro Glu Leu Ile Gln Gln Lys Ile Asp Asn Gln 
385                 390                 395                 400 


Gln Arg Thr Asp Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Ile Ala Ile Leu Ile 
            420                 425                 430         


Pro Lys Ser Lys Pro Glu Ser Lys Val Gly Asn Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Asp Tyr Leu Gln Lys Gly Lys Ala Glu Glu Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Ile Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Leu Lys Leu Pro Ala Asn Trp Asn Glu Phe Ala Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asp Ala Ala Met Glu Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Asp Val Leu Ile Thr Tyr Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Asp Val Glu Asp Asn Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Leu Glu Lys His Lys Leu 
            580                 585                 590         


Asp Lys Ser Val Lys Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Met Val Ser Lys Glu Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Ala Asp Thr Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Val Leu Glu Gly Asp Gly His Pro Phe Leu Thr Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Glu Leu Tyr Met Asn 
        675                 680                 685             


Ala Lys Val Gln Tyr Leu Ile Gln Phe Tyr Lys Pro Ser Lys Asp Lys 
    690                 695                 700                 


Val Asp Lys Arg Gly Arg Pro Thr Thr Glu Val Lys Leu Pro Pro Leu 
705                 710                 715                 720 


Asp Lys Arg Ser Asn Ile Pro Phe Thr Ile Arg Gln Trp Asp Glu Lys 
                725                 730                 735     


Glu Lys Tyr Asn Leu Asn Ala Trp Leu Arg Asn Val Thr Val Gly Lys 
            740                 745                 750         


Asn Thr Lys Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe 
        755                 760                 765             


Asp Glu Thr Leu Cys Asp Leu Leu Ser Gln Gln Leu Asp Ala Arg Thr 
    770                 775                 780                 


Val Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Leu Trp 
785                 790                 795                 800 


Trp Lys Thr Arg Asp Asp Ala Thr Gln Asp Phe Tyr Gln Ser Glu Arg 
                805                 810                 815     


Glu Tyr Asp Ile Tyr Glu Glu Lys Val Glu Phe Lys Ile Asp Ser Ser 
            820                 825                 830         


Gly His Phe Ala Asp Tyr Tyr Lys Lys Ala Leu Ser Lys Ala Tyr Asn 
        835                 840                 845             


Arg Leu Lys Ala Glu Arg Glu Ile Ala Arg Arg Thr Asn Lys Arg Leu 
    850                 855                 860                 


Pro Pro Ile Glu His Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile 
865                 870                 875                 880 


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
                885                 890                 895     


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asp Ser Gly Asn Leu Lys 
            900                 905                 910         


Leu Ser Thr Ile Lys Thr Ser Leu Asn Asn Thr Thr Gln Ile Lys Gln 
        915                 920                 925             


Lys Ile Leu Asn Lys Thr Ile Val Ala Glu Arg Lys Gln Lys Asn Tyr 
    930                 935                 940                 


Thr Glu Leu Arg Lys Tyr Val His Asp Arg Arg Leu Pro Asn Leu Phe 
945                 950                 955                 960 


Glu Tyr Val Glu Ala Asp Glu Ile Leu Leu Glu Trp Leu Leu Asp Glu 
                965                 970                 975     


Leu Met Ala Tyr Asn Ala Ala Lys Gln Gln Val Phe Asp Thr Ile Phe 
            980                 985                 990         


Met Leu Glu Lys Arg Ile Ile Glu  Thr Asp Pro Gln Glu  Leu Lys Ser 
        995                 1000                 1005             


Leu Phe  Thr Asn Glu Lys Gly  Gln Val Gln Thr Gly  Asn Ile Gln 
    1010                 1015                 1020             


His Lys  Pro Tyr Val Gln Trp  Leu Lys Asn Lys Gly  Leu Ile Asn 
    1025                 1030                 1035             


His Asn  Glu Lys Leu Phe Ile  Asn Met Val Arg Asn  Cys Phe Ser 
    1040                 1045                 1050             


His Asn  Gln Phe Pro Gln Arg  Glu Thr Met Glu Leu  Leu Ile Ser 
    1055                 1060                 1065             


Glu Trp  Gly Ala Gly Lys Ile  Ala Thr Gln Ile Leu  Thr Val Tyr 
    1070                 1075                 1080             


Asn Gln  Leu Ile Thr Asn Ile  Ile Asn Lys Ile 
    1085                 1090                 


<210>  2558
<211>  1124
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2558

Met Thr Leu Pro Ile Asn Asn Thr Phe Thr Ser Arg Ala Asp Arg Glu 
1               5                   10                  15      


Ile Leu Ser Gln Asn Lys Leu Phe Phe Gly Thr Tyr Leu Asn Met Ala 
            20                  25                  30          


Gln His Asn Thr Phe Leu Met Leu Thr Asp Ser Ser Glu Lys Val Gly 
        35                  40                  45              


Lys Thr Pro Pro Ser Ser Glu Gly Leu Trp Lys Asp Ala Gly Thr Phe 
    50                  55                  60                  


Ser Leu Leu Asn Thr Gln Gln Arg Pro Ser Ile Arg Ser Lys Ala Gly 
65                  70                  75                  80  


Arg Leu Ala Val Lys Gln Phe Val Ala Leu Glu Ser Leu Val Ile Glu 
                85                  90                  95      


Arg Glu Glu Gly Glu Ala Glu Thr Pro Pro Asp Val Glu Lys Leu His 
            100                 105                 110         


Asp Phe Leu Tyr Ser Ala Leu Glu Leu Leu Asn Asn Leu Arg Arg Glu 
        115                 120                 125             


Tyr Ser His Tyr Tyr His Glu Thr Ala Gln Asn Ile Asp Tyr Pro Lys 
    130                 135                 140                 


Leu Glu Ala Ile Phe Arg Glu Ala Lys Arg Val Ala Ile Glu Arg Leu 
145                 150                 155                 160 


Pro Lys Asp Asp Asp Lys Ala Lys Asn Lys Ala Glu Lys Lys Ile Val 
                165                 170                 175     


Lys Tyr Met Leu Arg Asn Glu Asp Glu Lys Leu Val Phe Phe Ile Ser 
            180                 185                 190         


Leu Phe Leu Ser Arg Gln Gln Ala Glu Ala Phe Met Ser Gln Ile Asn 
        195                 200                 205             


Asp Phe Lys Gly Glu His Asn Ala Leu Lys Arg Arg Val Phe Ala Gln 
    210                 215                 220                 


Leu Cys Cys Arg Leu Pro Arg Pro Lys Leu Glu Ser Ala Ala Leu Glu 
225                 230                 235                 240 


Leu Asp Ala Leu Asn Glu Leu Ala Arg Cys Pro Asp Glu Val Phe Arg 
                245                 250                 255     


Tyr Leu Asn Thr Glu Asp Lys Asn Arg Phe Val Val Pro Leu Lys Glu 
            260                 265                 270         


Leu Asp Lys Asp Asp Thr Ser Gly Asn Thr Ile Thr Leu Lys Arg Tyr 
        275                 280                 285             


Glu Asp Arg Leu Pro Tyr Leu Leu Met Arg Tyr Leu Asp Glu His Ala 
    290                 295                 300                 


Glu Asn Phe Gly Ile His Phe Gln Ile Trp Ala Gly Lys Leu Arg Thr 
305                 310                 315                 320 


Ala Asp Tyr Pro Lys Thr Ile Tyr Asp Ile Glu Asp Asn Arg Asn Ile 
                325                 330                 335     


His Glu Asn Leu Thr Ala Tyr Asp Thr Leu Gln Asn Leu Arg Asn Gly 
            340                 345                 350         


Asp Asn Ile Pro Asp Asn Trp Lys Met Gln Asp Gly Glu Leu Leu Thr 
        355                 360                 365             


Lys Ile Glu Gln Phe Ser Pro His Tyr Asn Ile Ile Asn Asn Arg Ile 
    370                 375                 380                 


Ala Leu Lys Leu Gly Asp Thr Ala Tyr Thr Glu Ile Tyr Pro Leu Ser 
385                 390                 395                 400 


Glu Asp Ser Lys Leu Asp Phe Arg Val Lys Asn Pro Leu Pro Asp Leu 
                405                 410                 415     


Ile Ile Ser Thr Tyr Asp Ile Pro Asn Leu Phe Leu Tyr Gln Tyr Leu 
            420                 425                 430         


His Gln Gln Gly Lys Ile Arg Leu Arg Pro Asp Ile Phe Ile Arg Gln 
        435                 440                 445             


Phe Ser Gly Lys Leu Arg Lys Val Phe Lys Asp Val Gln Ser Gly Glu 
    450                 455                 460                 


Leu Lys Pro Leu Gln Ala Glu Ala Phe Glu Lys Gln Gln Arg Tyr Ser 
465                 470                 475                 480 


Glu Arg Arg Gln Glu Ile Leu Glu Glu Arg Arg Ser Gln Leu Gln Ala 
                485                 490                 495     


Ile Leu Asp Asn Lys Tyr Lys Leu Val Lys Val Ser His Leu Pro Asp 
            500                 505                 510         


Ala Leu Arg Glu Tyr Leu Phe Asn Tyr Lys Ala Gln Asp Phe Asn Arg 
        515                 520                 525             


Gln Val Leu His Lys Ile Thr Glu Arg Met Glu Ala Asp Trp Gln Arg 
    530                 535                 540                 


Lys Lys Lys Ala Glu Tyr Gly Ser Gly Thr Asp Glu Pro Glu Leu Lys 
545                 550                 555                 560 


Ala Gly Asn Ile Gly Thr Tyr Ile Ala Arg Asp Ile Val Ala Leu Gln 
                565                 570                 575     


Pro Pro Asn Pro Gln Glu Val Asn Leu Gly Lys Pro Asn Asn Asp Gln 
            580                 585                 590         


Tyr Asn Glu Leu Gln Glu Ser Ile Ala Tyr Phe Gly Arg Glu Tyr His 
        595                 600                 605             


Val Leu Pro Ala Tyr Leu Arg Lys Glu Leu Gly Val Met Gly Glu Arg 
    610                 615                 620                 


Asn Asp Lys Thr Lys His Pro Phe Leu Val His Leu Asn Trp Asn Lys 
625                 630                 635                 640 


Cys His Thr Ala Lys Glu Phe Tyr Ile Glu Tyr Leu Asp Val Lys Arg 
                645                 650                 655     


Arg Trp Met Arg Ala Val Arg Asp Asp Ile Lys Ala Val Ser Pro Gln 
            660                 665                 670         


Thr Glu Gln Pro His Phe Val Lys Met Gln Arg Asn Ala Lys His Phe 
        675                 680                 685             


Gly Ile Asn Ile Asn Lys Ser Ala Leu Thr Asp Glu Gln Ile Gln Glu 
    690                 695                 700                 


Arg Tyr Gly Tyr Phe Leu Arg Ile Asn Ser Lys Ala Ala Lys Asp Arg 
705                 710                 715                 720 


Asn Tyr Leu Lys Thr Met Arg Lys Asn Pro Ile Ser Gly Asp Phe Glu 
                725                 730                 735     


Pro Thr Asp Asn Ala Pro Ile Met Leu Pro Arg Gly Ile Phe Asn Asp 
            740                 745                 750         


Ala Ile Arg Glu Ala Leu Arg Thr Asn Tyr Pro Asp Gln Ile Asn Asp 
        755                 760                 765             


Lys Ser Gly Met Ser Asp Phe Thr Arg Ile Met Ala Asn Asp Glu Asp 
    770                 775                 780                 


Leu Gln Thr Cys Tyr Ser Tyr Pro Arg His Tyr Arg Tyr Glu Ala Asp 
785                 790                 795                 800 


Asn Asp Lys Leu Phe Lys Asn Asp Arg Glu Lys Ala Arg His Thr Ile 
                805                 810                 815     


Asp Ile Lys Gly Asp Thr Ala Gln Ile Trp Gln Gly Leu Cys Asp Leu 
            820                 825                 830         


Lys Thr Glu Leu Lys Asp Asn Leu Thr Arg Ala Lys Asn Ser Gln Leu 
        835                 840                 845             


Lys Arg Leu Phe Glu Gln Val Asp Arg Gln Lys Lys Leu Trp Arg Arg 
    850                 855                 860                 


Ile Phe Arg Asn Glu Gln Ala Ile Arg Thr Val Ala Phe Lys Asp Arg 
865                 870                 875                 880 


Leu Val Trp Leu Met Val Lys Asp Ile Leu Thr Arg Lys Ser Gln Ala 
                885                 890                 895     


Glu Gln Ser Asn Leu Gln Leu Glu Gln Trp Gln Leu Gln Asp Thr Gly 
            900                 905                 910         


Phe Asp Val Arg Lys Thr Glu Val Trp Ile Leu Asp Gln Ala Ile Pro 
        915                 920                 925             


Thr Ser Leu Thr Ile His Asp Lys Asp Ile Cys Ala Asn Phe Gln Ser 
    930                 935                 940                 


Ala Glu Leu Asp Lys Ala Arg Glu Asn Glu Leu Pro Val Lys Arg Tyr 
945                 950                 955                 960 


Gly Glu Phe Arg Lys Met Leu Lys Asp Arg Arg Leu Phe Val Ala Asn 
                965                 970                 975     


Asn Ser Gly Leu Leu Arg Tyr Tyr Pro Glu Lys Ser Ile Leu Trp Thr 
            980                 985                 990         


Thr Leu Gln Asp Glu Leu Arg Asp  Tyr Asp Gln Cys Arg  Ala Glu Leu 
        995                 1000                 1005             


Leu Asn  Ala Ile Phe Ala Phe  Glu Gln Arg Val Leu  Ser Asn Gln 
    1010                 1015                 1020             


Gln Cys  Arg Gln His Leu Ser  Leu Thr Glu Asn Arg  Ile Asp His 
    1025                 1030                 1035             


Lys Val  Tyr Leu Glu Ala Tyr  Lys Ala Thr Tyr Gly  Asn Met Pro 
    1040                 1045                 1050             


Gln Pro  Ile Ser Asn Ile Asn  Gln Leu Arg Asn Lys  Phe Met His 
    1055                 1060                 1065             


Asn Gln  Ile Pro Tyr Asp Thr  Trp Ile Ser Gln Ala  Ile Glu His 
    1070                 1075                 1080             


Asn Thr  Asn Ala Asn Leu Pro  Ile Glu Asp His Arg  Asn Lys Asn 
    1085                 1090                 1095             


Val Val  Lys Gln Leu Ile Glu  Phe Ala Thr Glu Leu  Tyr Asp Gly 
    1100                 1105                 1110             


Met Asn  Glu Ile Leu Phe Tyr  Asn Lys Glu Asn 
    1115                 1120                 


<210>  2559
<211>  1152
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2559

Met Glu Thr Asp Ser Thr Lys Glu Val Gln Ala Tyr Asn Leu Ile Glu 
1               5                   10                  15      


Thr Pro Trp Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg His Asn Met 
            20                  25                  30          


Phe Leu Leu Ile Asn His Leu Thr Glu Lys Phe Ser Tyr Leu Asn Gly 
        35                  40                  45              


Glu Lys Leu Thr Asn Asp Glu Glu Ile Cys Thr Thr Lys His Leu Leu 
    50                  55                  60                  


Val Thr Ile Phe Asp Pro Val Gln Thr Ile Tyr Glu Asp Glu Arg Phe 
65                  70                  75                  80  


Lys Val Tyr Lys Tyr Leu Val Lys Arg His Tyr Leu Pro Phe Ile Lys 
                85                  90                  95      


Ile Phe His Glu Lys Asn Gly Tyr Gln Leu Asp Ser Asn Pro Ile Val 
            100                 105                 110         


Asp Tyr Lys Gly Leu His Asn Phe Leu Leu Ser Val Phe Asn Ser Leu 
        115                 120                 125             


Asn Ser Cys Arg Asn Ser Phe Thr His Tyr Leu Ser Val Asp Asn Thr 
    130                 135                 140                 


Gly Lys Lys Ile Asp Glu Arg Lys Pro Ile Leu Asp Lys Asn Met Lys 
145                 150                 155                 160 


Ser Thr Leu Glu Gln Leu Phe Lys Leu Ala Pro Thr Phe Ser Leu Lys 
                165                 170                 175     


Arg Phe Glu Ala Ser His Glu Glu Asn Asp Phe Asp His Leu Asn Leu 
            180                 185                 190         


Tyr Glu Leu Phe His Pro Asp Ser Ser Gln Leu Thr Glu His Gly Phe 
        195                 200                 205             


Tyr Phe Phe Ile Asn Leu Phe Leu Glu Arg Ser Tyr Ala Ile Lys Phe 
    210                 215                 220                 


Leu Lys Lys Ile Arg Gly Phe Lys Asn Asp Ser Thr Pro Ser Phe Arg 
225                 230                 235                 240 


Ala Thr Ile Gln Ala Phe Thr Ala Tyr Ser Leu Arg Ile Pro Asp Val 
                245                 250                 255     


Lys Leu Asp Val Glu Asp Lys Lys Leu Ser Leu Leu Leu Glu Met Leu 
            260                 265                 270         


Asn Glu Leu Gln Arg Cys Pro Lys Glu Leu His Ser His Leu Ser Asp 
        275                 280                 285             


Glu Asp Arg Lys Ile Phe Gln Pro Ser Leu Asp Glu Lys Asp Lys Ser 
    290                 295                 300                 


Asn Ile Leu Leu Asn Ser Thr Asp Tyr Glu Asn Ile Lys Asp Glu Asp 
305                 310                 315                 320 


Ile Asp Ser Leu Ile Ser Glu Ile Thr Ser Leu Arg Arg Glu Ser Asn 
                325                 330                 335     


Arg Phe Pro Tyr Phe Ala Leu Arg Phe Ile Asp Glu Phe Asp Leu Leu 
            340                 345                 350         


Pro His Ile Arg Phe Gln Ile Thr Leu Gly Lys Leu His Val Lys Ser 
        355                 360                 365             


Tyr Glu Lys Ile Ile Thr Gly Asn Lys Lys Asn Arg Arg Ile Val Glu 
    370                 375                 380                 


Thr Ile Gln Ala Phe Gly Lys Leu Ser Asp Phe Glu His Ser Glu Asp 
385                 390                 395                 400 


Glu Ile Leu Arg Asp Leu Gln Glu Val Gly Val Ile Glu Lys Gly Cys 
                405                 410                 415     


Tyr Phe Glu Gln Tyr Ala Pro His Tyr Asn Met Glu Asn Asn Gln Leu 
            420                 425                 430         


Pro Phe Tyr Leu Phe Asp Asp Lys Lys Thr Met Lys Tyr Pro Ser Thr 
        435                 440                 445             


Pro Thr Gly Phe Ile Ser Leu Asn Asp Leu Pro Lys Ile Val Ile Leu 
    450                 455                 460                 


Ala Lys Leu Phe Pro Val Asp Ser Lys Ser Lys Lys Cys Lys Val Glu 
465                 470                 475                 480 


Asp Ile Ile Lys Asp Phe Ile Glu Ile Asp Lys Thr Cys Tyr Leu Asn 
                485                 490                 495     


Tyr Asp Glu Leu Gln Lys Ile Lys Gln Gln Leu Ser Leu Ile Pro Glu 
            500                 505                 510         


Glu Phe Thr Arg Arg Ile Ile Gln Glu Lys Ser Ile Lys Gly Arg Asn 
        515                 520                 525             


Gly Lys Pro Asp Tyr Leu Asn Leu His Lys Glu Ile Asn Leu Leu Thr 
    530                 535                 540                 


Arg Leu Asn Lys Ser Lys Glu Glu Leu Cys Leu Leu Thr Ser Asp Glu 
545                 550                 555                 560 


Leu Arg Lys Leu Thr Arg Asp Arg Lys Glu Leu Glu Tyr Ile Asn Gln 
                565                 570                 575     


Ile Arg Tyr Leu His Phe Leu Asp Lys Arg Lys Gln Glu Leu Gln Lys 
            580                 585                 590         


Tyr Leu Pro Asn Gly Leu Leu Val Asn Gln Leu Pro Glu Gln Ile Thr 
        595                 600                 605             


Arg Tyr Leu Leu Asn Ile Asn Glu Pro Asp Thr Glu Lys Thr Ile Asp 
    610                 615                 620                 


Gln Lys Ile Lys Ala Val Tyr Asp Asp Cys Asn Ile Arg Leu Lys Arg 
625                 630                 635                 640 


Ile Lys Lys Glu Thr Glu Lys Pro Gln Tyr Glu Gln Asn Ile Lys Leu 
                645                 650                 655     


Gly Glu Leu Ala Thr Phe Leu Ala Arg Asp Ile Ile Lys Met Val Val 
            660                 665                 670         


Asp Lys Asp Val Lys Gln Lys Ile Thr Ser Pro Tyr Tyr Asn Asn Leu 
        675                 680                 685             


Gln Asn Lys Ile Ala Tyr Phe Ser Ile Ser Gln Ser Glu Ile Ile Ala 
    690                 695                 700                 


Leu Cys Asn Glu Leu Gln Leu Phe Asp Asn Asn Lys Gly His Val Phe 
705                 710                 715                 720 


Leu Ser Arg Gln Leu Ile Asn Lys Ser Asn Asn Ile Ile Asp Phe Tyr 
                725                 730                 735     


Lys Asn Tyr Leu Glu Thr Lys Cys Lys Trp Ile Thr Thr His Leu Ser 
            740                 745                 750         


Lys Glu Glu Ala Ile Pro Leu Ser Leu Leu Lys Ile Lys Glu Lys Val 
        755                 760                 765             


Gly Arg Asn Asp Phe Asn His Trp Leu Ser Asn Lys Ser Thr Met Pro 
    770                 775                 780                 


Val Ser Leu Pro Asn Thr Leu Phe Asp Lys Asp Val Ser Thr Tyr Leu 
785                 790                 795                 800 


Ser Lys Glu Leu His Lys Asn Arg Met Pro Phe Asn Gln Gly Asp Lys 
                805                 810                 815     


Phe Ser Ile Leu Leu Ser Lys Phe Leu Gln Gln Asp Thr Gln Pro Phe 
            820                 825                 830         


Tyr Arg Phe Lys Arg Ile Tyr Phe Val Asn Gly Glu Pro Lys Glu Ile 
        835                 840                 845             


Asp Ile Asn Asp Leu Asp Gly Lys Thr Leu Lys Ser Arg Tyr Gly Lys 
    850                 855                 860                 


Gln Val Glu Lys Asn Glu Lys Gln Ile Arg Phe Ile Gln Thr Gln Asp 
865                 870                 875                 880 


Arg Ile Ile Lys Leu Leu Cys Glu His Ile Leu Ser Glu Tyr Asn Ser 
                885                 890                 895     


Asp Ser His His Lys Ser Leu Lys Leu Ala Ser Ile Val Pro Phe Ser 
            900                 905                 910         


Glu Glu Ser Pro Leu Asn Asn Pro Phe Gln Phe Lys Gln Arg Ile Ile 
        915                 920                 925             


Arg Lys Gly Asn Glu Thr Tyr Phe Thr Val Ile Ala Lys Asp Asn Gln 
    930                 935                 940                 


Arg Gln Leu Asp Glu Ile Ser Ala Tyr Ser Gln Leu Thr Thr Glu Asp 
945                 950                 955                 960 


Glu Lys Asn Ser Phe Lys Gly Gln Lys Gly Tyr Glu Trp Thr Val Lys 
                965                 970                 975     


Asp Phe Gly Arg Phe Lys Lys Met Thr Phe Asp Arg Arg Ile Ser Ser 
            980                 985                 990         


Leu Ser Ser Tyr Phe Glu Asn Lys  Glu Val Thr Phe Lys  Phe Leu Asp 
        995                 1000                 1005             


Tyr Gln  Leu Lys Glu Tyr Asp  Lys Tyr Arg Glu Phe  Ile Phe Glu 
    1010                 1015                 1020             


Ser Thr  Phe Gln Leu Glu Gln  His Ile Cys Asp Ile  Ala Leu Glu 
    1025                 1030                 1035             


Asp Ile  Ile Arg Ile Glu Met  Lys His Arg Thr Asn  Asp Asn Asn 
    1040                 1045                 1050             


Phe Asn  Asn Val Gln Phe Asn  Lys Tyr Thr Glu Trp  Ile Glu Asp 
    1055                 1060                 1065             


Lys Gly  Leu Leu Asn Glu Asp  Lys Ile Cys Gln Leu  Lys Lys Ile 
    1070                 1075                 1080             


Arg Asn  Gly Phe Ser His Ser  Gln Phe Pro Asp Asn  Val Ser Gly 
    1085                 1090                 1095             


Ile Pro  Lys Ile Thr Gln Leu  Asn Ile Asn Gln Phe  Glu Glu Ile 
    1100                 1105                 1110             


Tyr Gly  Val Glu Gly Arg Lys  Gly Glu Ile Glu Asn  Leu Asn Leu 
    1115                 1120                 1125             


Ser Leu  Ser Lys Leu Ile Phe  Glu Asp Tyr Lys Ser  Ile Ile Asn 
    1130                 1135                 1140             


Asn Ile  Ile Pro Ser Val Ile  Asp His 
    1145                 1150         


<210>  2560
<211>  1131
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2560

Met Glu Lys Thr Ile Glu Asn Gln Thr Gln Ser Lys Arg Thr Leu Asn 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Asp Glu Glu Lys Ile Thr Thr Ser Phe Leu Val Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Arg Gln Ser Leu Val Tyr Ser Asn Leu Thr 
65                  70                  75                  80  


Arg Tyr Met His Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Asp 
                85                  90                  95      


Asp Glu Arg Asp Lys Ala Glu Asn Tyr Gly Lys Asp Phe Gly Asn Leu 
            100                 105                 110         


Thr Asp Thr Leu Lys Glu Ile Phe Lys Glu Leu Asn Glu Phe Arg Asn 
        115                 120                 125             


Asp Tyr Ser His Tyr Tyr Ser Thr Glu Lys Lys Asp Lys Arg Lys Thr 
    130                 135                 140                 


Ile Val Ser Asp Lys Leu Lys Asn Phe Leu Asn Ile Asn Tyr Thr Arg 
145                 150                 155                 160 


Ala Ile Lys Tyr Thr Lys Ser Arg Phe Ile Asn Val Phe Ser Asp Asn 
                165                 170                 175     


Asn Phe Cys Leu Ala Glu Glu Ala Lys His Val Glu Asn Asp Asn Thr 
            180                 185                 190         


Ile Thr Gln Asp Gly Ile Val Phe Phe Thr Ser Met Phe Leu Asp Arg 
        195                 200                 205             


Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile Ile Gly Leu Lys Gly Thr 
    210                 215                 220                 


Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Thr Leu Met Ala Phe Cys 
225                 230                 235                 240 


Val Asn Leu Pro His Asp Lys Phe Val Ser Glu Asn Ser Glu Gln Gln 
                245                 250                 255     


Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu 
            260                 265                 270         


Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln His Phe Leu Pro Lys Leu 
        275                 280                 285             


Asp Asp Glu Gln Ile Asp Asn Val Leu Glu Asn Ser Val Pro Tyr Thr 
    290                 295                 300                 


Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn Ile Thr Lys Lys Val Arg 
305                 310                 315                 320 


Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu Lys Phe Ile Asp Gln Lys 
                325                 330                 335     


Lys Leu Phe Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val 
            340                 345                 350         


Leu Asp Glu Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Lys Arg Thr 
        355                 360                 365             


Val Thr Glu Asn Thr Lys Ala Phe Gly Met Leu Gln Asp Leu Asn Asp 
    370                 375                 380                 


Glu Glu Asn Val Leu Asn Lys Ile Asn Thr Gly Glu Ser Lys Ala Lys 
385                 390                 395                 400 


Phe Asp Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Thr Lys Asn 
            420                 425                 430         


Thr Asp Asn Lys Ile Lys Ser Asn Leu Leu Gln Pro Leu Pro Glu Ala 
        435                 440                 445             


Phe Leu Ser Ile Asn Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
    450                 455                 460                 


Glu Gln Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn 
465                 470                 475                 480 


Asn Ser Lys Ile Leu Asn Lys Glu Phe Ile Lys Ala Ile Lys Leu Lys 
                485                 490                 495     


Leu Asn Asp Leu Asp Val Phe Tyr Lys Arg Ser Gln Gly Arg Lys Gln 
            500                 505                 510         


Lys His Ala Tyr Leu Thr Lys Asp Lys Lys Tyr Asp Asn Glu Lys Ile 
        515                 520                 525             


Asn Glu Leu Lys Asn Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu 
    530                 535                 540                 


Tyr Asn Leu Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp 
545                 550                 555                 560 


Leu Asn Ile Ala Asp Val Gln Ala Lys Asn Ala Ile Ser Asp Arg Ile 
                565                 570                 575     


Lys Leu Met Lys Arg Asp Cys Ile Asn Arg Leu Lys Ser Met Lys Lys 
            580                 585                 590         


Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp 
        595                 600                 605             


Ile Val Asp Met Ile Ile Asp Glu Glu Lys Lys Lys Lys Ile Thr Ser 
    610                 615                 620                 


Phe Tyr Tyr Asp Lys Met Gln Lys Cys Leu Ala Leu Phe Ala Asp Lys 
625                 630                 635                 640 


Glu Lys Lys Glu Leu Phe Ile Leu Ile Cys Asn Asn Glu Leu Lys Leu 
                645                 650                 655     


Asn Asp Asp Asp Gly His Pro Phe Phe Lys Asn Ile Asn Phe Ser Asn 
            660                 665                 670         


Tyr Lys Tyr Thr Ser Glu Ile Tyr Gln Lys Tyr Leu Glu Glu Lys Gly 
        675                 680                 685             


His Lys Met Val Lys Glu Tyr Asn Pro Arg Lys Glu Asn Tyr Val Glu 
    690                 695                 700                 


Lys Asp Lys Ser Trp Leu Glu Ile Asn Phe Tyr Lys Lys Glu Trp Asn 
705                 710                 715                 720 


Glu Asn Ala Lys Lys Asp Leu Thr Val Val Lys Leu Pro Asp Asp Lys 
                725                 730                 735     


Ser Lys Ile Pro Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser 
            740                 745                 750         


Phe Glu Asn Trp Phe Lys Tyr Val Thr Asn Gly Lys Glu Thr Thr Asp 
        755                 760                 765             


Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp Glu Thr Leu 
    770                 775                 780                 


Lys Glu Leu Leu Lys Lys Glu Leu Ser Lys Asn Asn Ile Glu Phe Lys 
785                 790                 795                 800 


Glu Glu Asp Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Asp Lys Cys 
                805                 810                 815     


Arg Asn Asp Lys Thr Gln Lys Phe Tyr Ser Ala Glu Arg Glu Tyr Thr 
            820                 825                 830         


Phe Glu Glu Glu Lys Leu Asn Phe His Ile Asn Thr Lys Ser Lys Phe 
        835                 840                 845             


Glu Glu Tyr Ile Asn Pro Glu Phe Ala Glu Lys Val Phe Arg Leu Lys 
    850                 855                 860                 


Asn Gln Asn Arg Glu Lys Asp Asn Ile Ser Gly Arg Arg Leu Pro Pro 
865                 870                 875                 880 


Leu Lys Met Lys Glu Val Thr Lys Asn Met Val Lys Arg Ile Gly Asn 
                885                 890                 895     


Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Leu Met Leu 
            900                 905                 910         


Leu Met Phe Glu Lys Leu Val Asp Asn Asn Leu Lys Leu Lys Leu Glu 
        915                 920                 925             


Asn Val Asp Lys Leu Leu Asn Glu Ser Ile Glu Ile Asn Gln Ser Ile 
    930                 935                 940                 


Ser Gly Lys Leu Ser Phe Asp Asp Ser Gly Asp Asn Glu Asn Lys Lys 
945                 950                 955                 960 


Asp Arg Ala Ile Ile Cys Arg Asn Ile Thr Glu Thr Arg Lys Arg Lys 
                965                 970                 975     


Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Glu Glu Glu  Asn Ile Pro Ile Glu  Lys Ile Lys 
        995                 1000                 1005             


Ile Glu  Leu Asp Thr Tyr Ser  Lys Ala Lys Asp Val  Val Phe Asp 
    1010                 1015                 1020             


Leu Ile  Phe Asp Leu Glu Arg  Ala Ile Ile Asn Lys  Asp Glu Asn 
    1025                 1030                 1035             


Arg Ile  Lys Glu Leu Asn Lys  Asp Lys Asn Gly Val  Ile Gln Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Phe Trp Leu  Leu Glu Lys 
    1055                 1060                 1065             


Asn Leu  Ile Thr Glu Gln Glu  Phe Thr Phe Met Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Thr  Phe Ser His Asn Gln  Phe Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Leu Phe  Ile Lys Asn Trp Asn  Glu Asn Glu Phe Ala  Lys Gln Ile 
    1100                 1105                 1110             


Leu Asn  Val Tyr Asn Gln Lys  Asn Asn Asn Leu Ile  Lys Ser Ile 
    1115                 1120                 1125             


Lys Asp  Ile 
    1130     


<210>  2561
<211>  1113
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2561

Met Glu Ser Leu Ile Gln Gln Glu Glu Asn Lys Ala Arg Asn Leu Ile 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg His Asn 
            20                  25                  30          


Ile Phe Ser Ile Asp Asn His Leu Ala Ser Tyr Phe Glu Thr Ser Lys 
        35                  40                  45              


Leu Ser Asn Glu Glu His Ile Ser Asp Ser Phe Leu Leu Ser Ala Asp 
    50                  55                  60                  


Lys Arg Lys Asn Lys Thr Asn Asn Glu Pro Ile Asn Glu Asn Leu Leu 
65                  70                  75                  80  


Phe Glu Arg Thr Leu Arg Phe Met Pro Ile Leu Arg Val Phe Asp Thr 
                85                  90                  95      


Glu Arg Leu Pro Lys Glu Val Arg Leu Asn Thr Val Asp Ile Gly Lys 
            100                 105                 110         


Asp Phe Asp Glu Met Arg Asn Cys Leu Lys Gln Val Phe Ser Glu Leu 
        115                 120                 125             


Asn Lys Phe Arg Asn Asp Tyr Thr His Tyr Phe Ser Thr Lys Thr Glu 
    130                 135                 140                 


Thr Asn Arg Lys Ile Gln Val Thr Ser Glu Leu Gly Glu Phe Leu Thr 
145                 150                 155                 160 


Arg Ser Phe Lys Leu Ala Ile Ala Phe Thr Lys Gln Arg Met Arg Asp 
                165                 170                 175     


Val Leu Lys Glu Glu Asp Tyr Ser Leu Val Glu Lys Lys Val Met Val 
            180                 185                 190         


His Pro Glu Glu Met Ser Ile Thr Thr Glu Gly Ile Val Phe Leu Ala 
        195                 200                 205             


Cys Met Phe Leu Glu Arg Glu Tyr Ala Phe Gln Phe Ile Gly Lys Val 
    210                 215                 220                 


Val Gly Leu Lys Gly Thr His Arg Asn Glu Phe Ile Ala Thr Arg Glu 
225                 230                 235                 240 


Val Leu Met Ala Tyr Cys Val Lys Leu Pro His Asp Lys Phe Ile Ser 
                245                 250                 255     


Glu Asp Ser Lys Gln Ala Leu Ile Leu Asp Ile Ala Asn Glu Leu Asn 
            260                 265                 270         


Lys Cys Pro Leu Thr Leu Tyr Asp Val Ile Thr Asp Glu Gly Arg Lys 
        275                 280                 285             


Gln Phe Arg Pro Glu Leu Thr Asp Asp Ala Lys Lys Ser Val Ile Glu 
    290                 295                 300                 


Asn Cys Ile Asn Glu Asp Leu Glu Val Asp Tyr Asn Glu Tyr Ile Gln 
305                 310                 315                 320 


Ile Leu Thr Lys Lys Val Arg Tyr Lys Asn Arg Phe Pro Tyr Phe Ala 
                325                 330                 335     


Phe Gln Tyr Ile Glu Glu Thr Lys Leu Leu Asp Asn Leu Arg Phe Ser 
            340                 345                 350         


Ile Asp Leu Gly Gln Phe Val Leu Ala Glu Tyr Glu Lys Arg Leu Ala 
        355                 360                 365             


Gly Glu Leu Thr Ser Arg Thr Val Val Glu Asn Val Lys Ala Phe Arg 
    370                 375                 380                 


Tyr Leu Arg Glu Val Ile Asp Glu Asp Val Val Leu Glu Leu Met Lys 
385                 390                 395                 400 


Ser Asn Pro Ser Leu Asn Arg Phe Leu Gln Phe Ser Pro His Tyr Ser 
                405                 410                 415     


Ser Asn Asn Asn Lys Ile Gly Ile Ser Ser Lys Pro Arg Ile Ser Val 
            420                 425                 430         


Val Lys Ser Lys Gly Lys Ile Glu Ser Lys Ile Asp Cys Leu Val Arg 
        435                 440                 445             


Gln Pro Leu Pro Glu Ala Phe Val Ser Ile His Glu Leu Thr Lys Ile 
    450                 455                 460                 


Ile Leu Leu Asp Tyr Leu Asn Lys Gly Ile Val Val Glu Ile Ile Asn 
465                 470                 475                 480 


Arg Phe Ile Asp Thr Asn Arg Ser Ile Ile Met Asp Arg Asp Lys Ile 
                485                 490                 495     


Lys Glu Ile Lys Glu Lys Leu Pro Asn Asn Glu Val Trp Val Pro Phe 
            500                 505                 510         


Arg Arg Leu Thr Asp Ser Lys Lys His Ser Ala Tyr Ser Glu Glu Gln 
        515                 520                 525             


Lys Asp Glu Ile Leu Arg Arg Lys Lys Met Leu Asn Glu Ile Leu Ser 
    530                 535                 540                 


Ser Tyr Ser Leu Asn Ile Lys Gln Ile Pro Ser Arg Ile Ile Asp Tyr 
545                 550                 555                 560 


Trp Leu Asn Ile Ile Asp Val Arg Lys Glu Arg Ser Phe Ser Asp Arg 
                565                 570                 575     


Ile Lys Leu Met Lys Arg Asp Cys Ala Asp Arg Tyr Lys Ala Val Lys 
            580                 585                 590         


Arg Asn Glu Lys Asp Lys Thr Val Ser Ile Pro Lys Ile Gly Glu Met 
        595                 600                 605             


Ala Thr Phe Leu Ala Lys Asp Ile Val Ala Met Ile Val Asp Glu Asp 
    610                 615                 620                 


Lys Lys Ser Lys Ile Thr Ser Phe Tyr Tyr Asp Lys Leu Gln Glu Cys 
625                 630                 635                 640 


Leu Ala Leu Tyr Ser Asn Ile Glu Lys Lys Asn Leu Phe Ile His Leu 
                645                 650                 655     


Val Thr Asn Glu Leu Lys Leu Asn Glu Lys Gly Gly His Pro Phe Leu 
            660                 665                 670         


Lys Arg Ile Asn Leu Asn Ser Ile Thr Arg Thr Lys Glu Leu Tyr Glu 
        675                 680                 685             


Ile Tyr Leu Ser Glu Lys Ala Tyr Lys Leu Asn Ser Lys Glu Asn Asp 
    690                 695                 700                 


Glu Ser Trp Met Ser Met Thr Phe Tyr His Leu Glu Trp Asn Glu Lys 
705                 710                 715                 720 


Ala Lys Lys Lys Met Thr Lys Val Val Tyr Pro Val Asn Asp Glu Gln 
                725                 730                 735     


Ile Pro Tyr Thr Ile Lys Gln Trp Asn Lys Ser Thr Gln Pro Leu Phe 
            740                 745                 750         


Asp Arg Phe Thr Asn Glu Gln Gly Lys Ser Ser Asp Trp Val Arg Leu 
        755                 760                 765             


Lys Pro Leu Asp Leu Pro Thr Asn Leu Phe Asp Glu Glu Ile Cys Val 
    770                 775                 780                 


Gln Leu Arg Ser Arg Leu Gln Glu Ala Lys Ile Pro Phe Asp Asn Lys 
785                 790                 795                 800 


Ser Asn Tyr Ser Glu Leu Leu Lys Leu Trp Trp Lys Ser Arg Asp Asp 
                805                 810                 815     


Ser Thr Gln Pro Phe Tyr Gln Leu Glu Arg Gln Tyr Asn Ile Tyr Asp 
            820                 825                 830         


Glu Ser Val Arg Phe Thr Leu Asn Ser Lys Asn Lys Phe Lys Asp Tyr 
        835                 840                 845             


Tyr Gln Ala Ala Leu Lys Lys Val Phe Asn Gln Lys Lys Ala Glu Arg 
    850                 855                 860                 


Glu Ala Lys Arg Arg Phe Asn Lys Arg Leu Pro Asp Ile Gln Phe Lys 
865                 870                 875                 880 


Asp Val Glu Arg Val Phe Lys His Ala Ile Ala Glu Thr Glu Lys Gln 
                885                 890                 895     


Ile Arg Ile Ile Gln Glu Glu Asp Arg Ile Met Leu Leu Met Leu Glu 
            900                 905                 910         


Lys Leu Met Asp Asp Gln Gln Leu Lys Leu Gly Lys Ala Glu Ala Leu 
        915                 920                 925             


Leu Ser Ser Thr Val Pro Ile Lys Gln Lys Ile Gly Asp Lys Thr Asn 
    930                 935                 940                 


Ser Ser Arg Val Ile Val Ala Gln Arg Lys Gln Lys His Tyr Thr Val 
945                 950                 955                 960 


Leu Arg Lys Tyr Gln Tyr Asp Arg Arg Leu Pro Glu Leu Phe Lys Tyr 
                965                 970                 975     


Thr Thr Glu Lys Glu Glu Leu Lys Leu Glu Trp Leu Glu Asp Glu Leu 
            980                 985                 990         


Lys Ala Tyr Asn Lys Gly Lys Leu  Lys Val Phe Asp Leu  Val Phe Ser 
        995                 1000                 1005             


Leu Glu  Lys Arg Ile Ile Asp  Val Ala Lys Gln Asp  Ile Ile Ala 
    1010                 1015                 1020             


Leu Phe  Asp Lys Pro Gly Ser  Asn Asp Ser Lys Phe  Asn Val Val 
    1025                 1030                 1035             


His Ser  Pro Tyr Ile Thr Trp  Leu Glu Lys Met Glu  Leu Ile Asn 
    1040                 1045                 1050             


Ser Val  Glu Ala Gly Phe Met  Lys Lys Ile Arg Asn  Ser Phe Ser 
    1055                 1060                 1065             


His Asn  Gln Phe Pro Glu Cys  Gln Thr Val Glu Leu  Met Ile Ser 
    1070                 1075                 1080             


Leu Lys  Ser Asp Ile Pro Ile  Ala Thr Gln Ile Val  Asn Glu Tyr 
    1085                 1090                 1095             


Glu Arg  Leu Ile Leu Arg Ile  Asn Cys Gln Ile Glu  Lys Met Lys 
    1100                 1105                 1110             


<210>  2562
<211>  1153
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2562

Met Glu Gln Glu Tyr Asp Phe Phe Asn Lys Thr Asp Lys His Phe Phe 
1               5                   10                  15      


Ala Gly Leu Phe Asn Thr Ala Leu Asn Asn Phe Asp Leu Ser Leu Ala 
            20                  25                  30          


Glu Leu Asn Lys Arg Met Asn Tyr Lys Glu Ile Lys Gly Asn Glu Lys 
        35                  40                  45              


Glu Ile Ile Ile Ile Glu Tyr Ala Phe Asn Lys Asp Glu Arg Thr Gln 
    50                  55                  60                  


Leu Asp Phe Glu Asn Asn Phe Lys Tyr Leu Ser Glu Ser Leu Ile Phe 
65                  70                  75                  80  


Leu Asn Arg Ile Pro Ser Phe Ile Ala His Lys Asn Lys Asn Gly Ser 
                85                  90                  95      


Thr Ile Ile Leu Lys Asp Phe Leu Lys Asp Phe Leu Cys Gly Leu Tyr 
            100                 105                 110         


Gln Thr Leu Leu Asn Tyr Arg Asn Tyr Tyr Thr His Phe Glu His Asp 
        115                 120                 125             


Asp Val Ala Ile Gly His Pro Leu Ile Ala Glu Phe Leu Glu Tyr Leu 
    130                 135                 140                 


Leu Phe Asn Ser Val Ser Arg Val Lys Asp Asp Arg Val Lys Thr Lys 
145                 150                 155                 160 


Ala Val Lys Asp Lys Leu Leu Ser Lys Tyr Lys Asp Asp Tyr Thr Thr 
                165                 170                 175     


Ile Ile Glu Tyr Lys Asn Lys Trp Ile Cys Asp Lys Asn Glu Glu Leu 
            180                 185                 190         


Ile Asn Glu Gly Arg Lys Thr Phe Lys Lys Ile Asn Asn Asn Ser Glu 
        195                 200                 205             


Ala Gly Tyr Asn Tyr Val Leu Asn Ser Ile Phe Arg Arg Phe Ile Asp 
    210                 215                 220                 


Asp Ser Thr Asn Thr Pro Lys Leu Gln Leu Asp Glu Lys Cys Ser Thr 
225                 230                 235                 240 


Asp Asp Gly Leu Thr Lys Val Gly Phe Ile Gln Phe Leu Ala Leu Leu 
                245                 250                 255     


Leu Asn Lys Arg Gln Val Ser Leu Leu Phe Asp Asn Ile Thr Tyr Thr 
            260                 265                 270         


Arg Tyr Thr Asp Thr Gln Leu Gln Arg Val Ile Thr Arg Trp Ile Phe 
        275                 280                 285             


Thr Tyr Glu Ser Tyr Arg Asp Ile Asn Tyr Leu Phe Lys Ser Glu Tyr 
    290                 295                 300                 


Asp Glu His Ala Leu Leu Leu Gln Met Val Ser Glu Leu Thr Lys Cys 
305                 310                 315                 320 


Pro Lys Asn Leu Tyr Pro Tyr Leu Ser Glu Lys Asn Lys Asp Asn Phe 
                325                 330                 335     


Leu Glu Asp Ile Asn Ile Tyr Phe Lys Glu Asn Ala Lys Leu Phe Glu 
            340                 345                 350         


Asp Asp Ala Leu Val Ser His Glu Val Val Arg Lys Arg Phe Glu Asp 
        355                 360                 365             


Lys Phe Pro Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe Ala Lys Phe 
    370                 375                 380                 


Pro Ser Leu Arg Phe Gln Val Asn Met Gly Lys Phe Asn His Asp Ser 
385                 390                 395                 400 


Arg Glu Lys Glu Phe Ile Ser Thr Gly Lys Lys Thr Glu Arg Leu Ile 
                405                 410                 415     


Leu Glu Asn Leu Thr Val Phe Glu Asn Leu Ser Glu Ala Thr Lys Lys 
            420                 425                 430         


Lys Asn Leu Tyr Phe Glu Lys Ser Asp Ser Lys Glu Lys Ser Asp Lys 
        435                 440                 445             


Glu Ser Asn Tyr Lys Asp Val Ser Asp Ser Ile Glu Val Ser Asp Trp 
    450                 455                 460                 


Val Glu Tyr Pro Arg Pro Lys Tyr Gln Phe Asn Lys Asn Thr Ile Gly 
465                 470                 475                 480 


Ile Trp Leu Asp Cys Asp Gly Leu Gly Asn Tyr Asp Glu Ser Pro Lys 
                485                 490                 495     


Arg Glu Asn Lys Lys Pro Thr Lys His Asp Ile Leu Asp Lys Ile Glu 
            500                 505                 510         


Leu Lys Asp Ser Phe Lys Lys Pro Ile Ala Tyr Leu Ser Leu His Glu 
        515                 520                 525             


Leu Pro Ala Leu Leu Tyr Cys Leu Leu Ile Glu Lys Lys Asp Gly Arg 
    530                 535                 540                 


Phe Ile Glu Asn Arg Ile Lys Gly Lys Ile Arg Lys Gln Arg Ser Phe 
545                 550                 555                 560 


Leu Glu Ser Leu Lys Gly Asp Tyr Gln Tyr Ser Glu Glu Glu Leu Lys 
                565                 570                 575     


Gln Phe Pro Lys Lys Ile Arg Leu Ile Leu Thr Lys Lys Ser Asn Ile 
            580                 585                 590         


Asn Ser Glu Lys Ile Lys Arg Gln Ile Ser Asn Glu Ile Lys Val Asn 
        595                 600                 605             


Pro Leu Lys Glu Ile Arg Glu Lys Tyr Thr Pro Lys Ser Glu Thr Glu 
    610                 615                 620                 


Leu Ser Leu Ser Glu Lys Gly Lys Ile Ala Thr Trp Leu Ser Lys Asp 
625                 630                 635                 640 


Ile Lys Arg Phe Val Ala Lys Asp Val Lys Gly Pro Ser Glu Glu Asp 
                645                 650                 655     


Lys Asn Lys Ser Trp Lys Gly Tyr Gln Phe Ser Glu Phe Gln Ala Leu 
            660                 665                 670         


Leu Ser Tyr Tyr Asp Ile Asp Lys Ser Lys Leu Ser Asp Phe Val Phe 
        675                 680                 685             


Lys Asp Leu Asn Phe Asn Ile Asn Lys Asp Phe Pro Phe Gln Gly Ile 
    690                 695                 700                 


Val Phe Asn Lys Ser Ser Leu Phe Asp Phe Tyr Thr His Tyr Leu Lys 
705                 710                 715                 720 


Ser Arg Arg Glu Tyr Leu Asn His Leu Leu Glu Asn Phe Ser Asn Thr 
                725                 730                 735     


Thr Asn Glu Glu Leu Leu Leu Pro Phe Lys Ala Ser Lys Phe Lys Ile 
            740                 745                 750         


Lys Glu Leu Glu Glu Tyr Arg Lys Asn Lys Leu Glu Glu Pro Val Met 
        755                 760                 765             


Leu Val Arg Gly Val Phe Asp Asp Lys Pro Thr Ala Ser Arg Glu Lys 
    770                 775                 780                 


Asp Lys Thr Glu Phe Ala Lys Trp Phe Thr Val Ser Met Asn Ser Ser 
785                 790                 795                 800 


Ser Ala Gln Lys Phe Tyr Asp Phe Asp Lys Ile Tyr Pro Leu Thr Leu 
                805                 810                 815     


Ser Val Ile Asn Gly Arg Lys Ser Glu Glu Asn Leu Thr Ile Asn Thr 
            820                 825                 830         


Lys Ala Gly Leu Thr Lys Gln Tyr Ile Pro Phe Gln Ser Ile Arg Asn 
        835                 840                 845             


Lys Asp Ser Phe Val Leu Thr Asp Phe Glu Lys Glu Glu Ile Lys Lys 
    850                 855                 860                 


Asn Ile Lys Asn Pro Asn Glu Asn Leu Asn Lys Asn Phe Tyr Lys Tyr 
865                 870                 875                 880 


Lys Gln Lys Gln Ile Tyr Lys Asn Glu Ala Thr Ile Arg Lys Thr Met 
                885                 890                 895     


Arg Asn Asp Tyr Tyr Met Leu Gln Met Ile Lys Thr Phe Phe Ile Asp 
            900                 905                 910         


Thr Asn Glu Phe Ile Asn Ser Thr Phe Glu Asn Ile Ser Leu Lys Asp 
        915                 920                 925             


Phe Tyr Leu Thr Lys Ala Glu Lys Glu Lys Ile Gln Lys Asn Ala Ile 
    930                 935                 940                 


Ser Gln Ser Glu Lys Glu Lys Gly Asp Lys Thr Asn Val Ile Phe Asn 
945                 950                 955                 960 


Glu Ser Tyr Ile Leu Asp Lys Arg Val Glu Leu Ser Leu Leu Glu Gly 
                965                 970                 975     


Lys Ile Ile Gly Asn Val Ala Leu Lys Asp Arg Gly Lys Tyr Lys Lys 
            980                 985                 990         


Leu Ser Gln Asp Gln Lys Val Lys  Gln Leu Thr Glu Tyr  Phe Asp Lys 
        995                 1000                 1005             


Thr Trp  Ser Phe Glu Glu Ile  Ile Asn Glu Ile Ser  Asp Tyr Glu 
    1010                 1015                 1020             


His Ile  Arg Ser Lys Val Phe  Phe Asn Ser Val His  Glu Leu Glu 
    1025                 1030                 1035             


Glu Lys  Ile Tyr Leu Lys Ala  Lys Thr Glu Asn Lys  Val Glu Glu 
    1040                 1045                 1050             


Leu Lys  Asp Lys Gly His His  Asn Phe Arg Asn Tyr  Leu Lys Tyr 
    1055                 1060                 1065             


Tyr Phe  Ile Asn Asp Glu His  Gln Lys Glu Glu Phe  Asn Lys Ile 
    1070                 1075                 1080             


Lys Arg  Thr Asn Ser Ile Leu  Glu Val Lys Glu Glu  Phe Lys Gln 
    1085                 1090                 1095             


Leu Ile  Leu Leu Ile Glu Ile  Arg Asn Lys Phe Ala  His Asn Gln 
    1100                 1105                 1110             


Leu Ile  Pro Lys Thr Ser Phe  Asp Tyr Leu Thr Ser  Lys Phe Ser 
    1115                 1120                 1125             


Met Glu  Thr Asn Glu Arg Val  Ala Ser Tyr Leu Asn  Arg Ile Phe 
    1130                 1135                 1140             


Asn Thr  Ile Lys Thr Glu Ile  Leu Ile Arg 
    1145                 1150             


<210>  2563
<211>  1184
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2563

Met Glu Asn Lys Glu Asn Lys Val Lys Ser Val Arg Thr Thr Pro Glu 
1               5                   10                  15      


Tyr Phe Gly Ser Tyr Leu Asn Met Ala Arg His Asn Val Phe Leu Leu 
            20                  25                  30          


Ile Asn His Leu Thr Lys Thr Phe Asn Tyr Leu Pro Phe Gln Leu Leu 
        35                  40                  45              


Lys Asp Asp Ser Trp Ile Ser Val Val Glu Asn Asn Leu Leu Leu Asn 
    50                  55                  60                  


Ile Phe Asp Ser Ser Lys Arg Glu Phe Glu Asp Asp Arg His Lys Val 
65                  70                  75                  80  


Tyr Asn Tyr Ile Ile Lys Arg His His Phe Pro Val Ile Lys Tyr Leu 
                85                  90                  95      


Gly Leu Ser Asp Asp Gln Leu Val Asp Phe Asp Lys Val His Asn Phe 
            100                 105                 110         


Leu Leu Leu Ala Phe Thr Glu Leu Asn Asn Tyr Arg Asn Glu Tyr Thr 
        115                 120                 125             


His Tyr Leu Ser Ile Asp Asn His Gly Asn Lys Leu Ala Arg Lys Leu 
    130                 135                 140                 


Asp Ile Asp Asp Lys Leu Lys Ser Asn Ile Asn Asp Leu Phe Thr His 
145                 150                 155                 160 


Ala Pro Glu Ile Ser Tyr Leu Arg Lys Ser Glu Thr Gln Thr Lys Glu 
                165                 170                 175     


Asp Tyr Glu His Ile Leu Ser Gln Tyr Arg Leu Phe Asp Glu His Lys 
            180                 185                 190         


Met Phe Thr Glu Gln Gly Leu Tyr Phe Phe Ile Asn Leu Phe Leu Glu 
        195                 200                 205             


Arg Lys Tyr Ala Ile Lys Leu Leu Lys Lys Ile Arg Gly Phe Lys Asn 
    210                 215                 220                 


Glu Thr Thr Pro Thr Phe Lys Gly Thr Leu Gln Ala Phe Thr Ser Tyr 
225                 230                 235                 240 


Cys Ile Lys Ile Pro Asp Thr Arg Leu Gly Asn Glu Phe Pro Lys His 
                245                 250                 255     


Ser Leu Leu Met Glu Met Leu Ser Glu Leu Asn Lys Cys Pro Lys Glu 
            260                 265                 270         


Leu Phe Asn His Leu Thr Thr Gln Asp Lys Glu Lys Phe Glu Pro Lys 
        275                 280                 285             


Met Asp Glu Glu Arg Gln Asn Asn Val Arg Leu Asn Ser Ile Asn Tyr 
    290                 295                 300                 


Glu Asn Ile Glu Asp Glu Asp Ile Glu Ser Ile Val Lys Glu Leu Ile 
305                 310                 315                 320 


Ser Leu Lys Arg Tyr Glu Asp Arg Phe Pro Tyr Phe Ala Leu Arg Phe 
                325                 330                 335     


Ile Glu Asp Thr Asn Ser Phe Lys Gln Ile Asn Phe Gln Ile Thr Leu 
            340                 345                 350         


Gly Lys Leu Ile Ile Lys Arg Tyr Asp Lys Thr Ile Ile Gly Ile Ser 
        355                 360                 365             


Gln Asp Arg Arg Val Leu Lys Thr Ile Asn Ala Phe Gly Lys Leu Ser 
    370                 375                 380                 


Asp Phe Ile Asp Lys Glu Asp Glu Val Leu Ser Glu Leu Lys Lys Glu 
385                 390                 395                 400 


Leu Gln Asp Glu Asn Ile Ala Phe Glu Gln Tyr Ala Pro His Tyr Asn 
                405                 410                 415     


Ile Ser Gly Asn Lys Ile Gly Phe Lys Ile Phe Asp Lys Glu Val Asp 
            420                 425                 430         


Arg Lys Gln Leu Pro Leu Val Phe Glu Asn Lys Lys Glu Asn Pro Thr 
        435                 440                 445             


Ile Gln Asn Asn Pro Ser Gly Phe Ile Ser Ile His Asp Leu His Lys 
    450                 455                 460                 


Ile Ile Leu Leu Asn Leu Val Asp Ser Thr Ile Pro Ala Glu Gly Lys 
465                 470                 475                 480 


Ile Ile Asp Phe Ile Asp Asn Thr Asn Ala Asn Ile Leu Asp Ile Lys 
                485                 490                 495     


Ile Leu Asp Glu Ile Lys Ala Met Thr Gln Tyr Asp Gln Glu Ser Phe 
            500                 505                 510         


Thr Lys Lys Thr Met Asn Asp Lys Lys Thr Leu Lys Leu Thr Ser Leu 
        515                 520                 525             


Gly Asp Glu Phe Ile Lys Asn Tyr Leu Asn Leu Asp Lys Glu Asn Phe 
    530                 535                 540                 


Thr Asn Gln Leu Asn Gln Cys Ser Asp Gln Gln Lys Lys Asp Phe Ala 
545                 550                 555                 560 


Ile Asn Lys Asp Val Ser Thr Leu Leu Ile Lys Gln Thr Leu Ile Glu 
                565                 570                 575     


Asn His Ser Lys Glu Arg Tyr Lys Ile Leu Leu Lys Gln Arg Val Lys 
            580                 585                 590         


Ile Leu Gln Asp Asn Leu Pro Gln Asp Ile Leu Val Asn Gln Leu Pro 
        595                 600                 605             


Glu Lys Ile Lys Asp Tyr Leu Leu Asn Ile Ser Glu Ser Asn Ala Glu 
    610                 615                 620                 


Lys Lys Val His Leu Lys Ile Arg Ala Ile Leu Lys Asp Thr Glu Leu 
625                 630                 635                 640 


Leu Leu Lys Asp Ala Lys Lys Glu Pro Gln Glu Gly Glu Ile Ile Lys 
                645                 650                 655     


Leu Gly Lys Tyr Ala Thr Tyr Ile Ala Arg Asp Ile Leu Asn Met Ile 
            660                 665                 670         


Ile Asp Lys Asp Val Lys Gln Lys Val Thr Gln Pro Tyr Tyr Asn Lys 
        675                 680                 685             


Ile Gln Asn Lys Ile Ser Tyr Phe Ser Ile Asn Lys Glu Glu Leu Ile 
    690                 695                 700                 


Ala Ile Leu Lys Glu Leu Asp Ile Phe Asp Phe Asn Ser Gly His Val 
705                 710                 715                 720 


Phe Leu Arg Glu Phe His Ile Thr Asn Ser Lys Gly Leu Lys Asp Phe 
                725                 730                 735     


Tyr Lys Asn Tyr Leu Glu Gln Lys Ile Lys Trp Ile Asn Arg Lys Leu 
            740                 745                 750         


Phe Glu Lys Gly Lys Ala Gly Gly Tyr Arg Leu Asn Asn Pro Ser Val 
        755                 760                 765             


Lys Leu Pro Tyr Ser Phe Thr Val Ile Gln Lys Glu Ala Glu Ala Val 
    770                 775                 780                 


Asp Phe Glu Lys Trp Leu Asn Asn Lys Ser Met Met Pro Val Asn Ile 
785                 790                 795                 800 


Pro Asn Ser Leu Phe Asp Gln Ser Ala Asn Asp Ile Leu Lys Val Ile 
                805                 810                 815     


Leu Lys Asn Thr Gly Thr Asp Phe Lys Glu Thr Asp Thr Leu Ser Val 
            820                 825                 830         


Leu Leu Arg Lys Ile Cys Ser Lys Asp Thr Gln Pro Phe Tyr Ser Tyr 
        835                 840                 845             


Asp Arg Val Tyr Arg Asp Ser Asn Lys Glu Pro Ile Thr Ile Lys Gln 
    850                 855                 860                 


Leu Ser Gly Leu Gln Ser Lys Thr Ile Lys Ala Lys Tyr Gly Ser Phe 
865                 870                 875                 880 


Ala Glu Ala Asn Glu Lys Leu Ile Arg Phe Tyr Gln Thr Lys Asp Arg 
                885                 890                 895     


Val Val Lys Leu Met Cys Asp Phe Leu Leu Asn Glu Asp Gln Asn Leu 
            900                 905                 910         


Ala Asp Glu Lys Gly Phe Leu Leu Lys Asn Ile Tyr Pro Asn Ser Glu 
        915                 920                 925             


Ile Ser Ile Leu Asn His Pro Ala Lys Phe Lys His Ser Leu Lys Lys 
    930                 935                 940                 


Glu Gly Lys Ser Thr Asp Ile Leu Phe Asn Val Ile Ala Glu Asp Ser 
945                 950                 955                 960 


Pro Glu Gln Ile Ala Gln Val Glu Asn Trp Lys Lys Leu Asp Ile Glu 
                965                 970                 975     


His Arg Lys Ile Trp Thr Asp Ile Gln Thr Arg Glu Glu Gln Gln Ala 
            980                 985                 990         


Phe Leu Glu Asn Cys Thr Pro Glu  Glu Arg Lys Leu Tyr  Asn Gly Gln 
        995                 1000                 1005             


Lys Gly  Phe Gln Trp Lys Phe  Lys Asp Tyr Gly Arg  Phe Arg Arg 
    1010                 1015                 1020             


Phe Leu  Lys Asp Lys Arg Leu  Val Gly Leu Ser Glu  Tyr Phe Glu 
    1025                 1030                 1035             


Val Lys  Glu Ile Pro Phe Glu  Phe Leu Glu Tyr Gln  Met Met Glu 
    1040                 1045                 1050             


Tyr Asp  Arg Val Arg Asp Lys  Val Phe Glu Leu Val  Phe Met Leu 
    1055                 1060                 1065             


Glu Lys  Ala Ile Phe Glu Lys  Asp Pro Asn Gly Ile  Ile Asn Ile 
    1070                 1075                 1080             


Glu Met  Gln Glu Arg Ser Gly  Lys Lys Lys Thr Phe  Asp Gln Val 
    1085                 1090                 1095             


Glu Phe  Lys Thr Tyr Leu Arg  Trp Leu Glu Glu Lys  Gln Ile Tyr 
    1100                 1105                 1110             


Phe Ser  Lys Asp Ile Ile Gln  Trp Gly Arg Asn Lys  Phe Ser His 
    1115                 1120                 1125             


Ser Gln  Phe Pro Lys Phe Glu  Asn Ile Gln Lys Ile  Thr Asp Glu 
    1130                 1135                 1140             


Glu Ile  Ala Asn Phe Asn Tyr  Tyr Lys Asp Val Phe  Ala Gly Lys 
    1145                 1150                 1155             


Ser Asn  Ile Asp Ile Ser Ile  Ala Glu Lys Ile Ile  Lys Lys Phe 
    1160                 1165                 1170             


Glu Ser  Glu Ile Asn Arg Ile  Val Ser Thr Ile 
    1175                 1180                 


<210>  2564
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2564

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2565
<211>  1091
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2565

Met Lys Glu Glu Glu Lys Gly Lys Thr Pro Val Val Ser Thr Tyr Asn 
1               5                   10                  15      


Lys Asp Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His 
            20                  25                  30          


Asn Val Tyr Ile Thr Val Asn His Ile Asn Lys Ile Leu Gly Glu Ala 
        35                  40                  45              


Glu Ile Asn Ile Asp Gly Tyr Asp Ile Ser Leu Lys Asn Ile Trp Ser 
    50                  55                  60                  


Gly Ile Arg Asp Ile Asn Lys Lys Ala Arg Leu Glu Glu Leu Met Ile 
65                  70                  75                  80  


Lys His Phe Pro Phe Leu Glu Ala Met Thr His Gln Gln Arg Leu Thr 
                85                  90                  95      


Gly Asn Thr Lys Gln Lys Glu Glu Lys Gln Ala Lys Ile Gln Ser Phe 
            100                 105                 110         


Glu Ile Leu Lys Asp Asn Leu Phe Leu Leu Leu Lys Met Leu Gln Asp 
        115                 120                 125             


Leu Arg Asn His Tyr Ser His Tyr Lys His Ser Lys Ser Leu Glu Arg 
    130                 135                 140                 


Pro Lys Phe Asp Glu Asp Ile Arg Asn Lys Leu Tyr Asn Ile Phe Asp 
145                 150                 155                 160 


Thr Ser Ile Arg Leu Val Lys Glu Asp Tyr Lys His Asn Pro Asp Ile 
                165                 170                 175     


Lys Pro Lys Glu His Phe Lys His Leu Asp Arg Lys Arg Asn Glu Lys 
            180                 185                 190         


Phe Arg Tyr Ser Phe Ala Asp Asn Glu Gly Asn Ile Thr Ile Ser Gly 
        195                 200                 205             


Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp 
    210                 215                 220                 


Val Gln Lys Lys Leu Glu Gly Phe Arg Cys Ser Asn Glu Ser Tyr Gln 
225                 230                 235                 240 


Lys Met Thr Asn Glu Val Phe Cys Arg Asn Arg Ile Leu Met Pro Lys 
                245                 250                 255     


Leu Arg Leu Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met 
            260                 265                 270         


Leu Asn Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Lys 
        275                 280                 285             


Gly Glu Asp Arg Lys Lys Phe Glu Val Pro Phe Asp Ser Thr Asp Glu 
    290                 295                 300                 


Asp Tyr Asp Ala Glu Gln Asp Pro Phe Lys Asn Thr Leu Ile Arg Tyr 
305                 310                 315                 320 


Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe Asp Tyr Asn Glu 
                325                 330                 335     


Ile Phe Glu Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe 
            340                 345                 350         


Ser Ile Tyr Lys Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg His Leu 
        355                 360                 365             


Thr His Lys Leu Tyr Gly Phe Glu Arg Leu Gln Glu Phe Ala Lys Gln 
    370                 375                 380                 


Asn Arg Pro Asp Glu Trp Lys Ala Ile Ile Lys Asp Leu Asp Thr Phe 
385                 390                 395                 400 


Lys Lys Gln Glu Asp Glu Lys Val Asn Glu Lys Pro Tyr Ile Ser Glu 
                405                 410                 415     


Thr Thr Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Ala Phe 
            420                 425                 430         


Lys Asn His Asn Ile Trp Pro Thr Thr Asn Thr Glu Phe Thr Asn Asn 
        435                 440                 445             


Lys Arg Lys Lys Tyr Asn Leu Gly Thr Ser Ile Lys Ala Glu Ala Phe 
    450                 455                 460                 


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Met Leu Leu 
465                 470                 475                 480 


Lys Ile Lys Asn Glu Gly Pro Arg Lys Val Glu Ala Ile Ile Glu Ser 
                485                 490                 495     


Lys Ile Lys Asp Ile Phe Thr Leu Tyr Asp Ala Phe Ala Asn Asp Glu 
            500                 505                 510         


Ile Asp Asn Thr Asp Glu Leu Glu Lys Tyr Cys Glu Asp Lys Asp Ile 
        515                 520                 525             


Lys Ile Gly His Leu Pro Lys Gln Met Ile Ala Ile Leu Tyr Asn Lys 
    530                 535                 540                 


His Lys Asp Met Val Glu Lys Ala Lys Val Lys Gln Glu Lys Met Lys 
545                 550                 555                 560 


Leu Ala Thr Glu Asn Arg Leu Lys Thr Leu Asp Lys Leu Ile Glu Gly 
                565                 570                 575     


Lys Met Lys Tyr Ala Lys Arg Gly Ile Ser Pro Leu Lys Ser Gly Glu 
            580                 585                 590         


Ile Ala Ser Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln 
        595                 600                 605             


Arg Asp Glu Asn Gly Glu Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr 
    610                 615                 620                 


Glu Tyr Gln Leu Leu Gln Arg Thr Leu Ala Leu Phe Gly Ser Glu His 
625                 630                 635                 640 


Lys Arg Leu Thr Pro Tyr Phe Lys Gln Met Asn Leu Ile Gly Asp Asn 
                645                 650                 655     


Asn Ser His Pro Phe Leu Lys Gln Thr Glu Trp Glu Glu Cys Asn Asn 
            660                 665                 670         


Ile Leu Ser Phe Tyr Arg Ser Tyr Leu Glu Ala Arg Lys Asn Phe Leu 
        675                 680                 685             


Lys Asn Leu Glu Pro Lys Asp Trp Lys Lys Asn Gln Tyr Phe Leu Lys 
    690                 695                 700                 


Ile Lys Glu Pro Lys Ser Asn Arg Gln Thr Leu Val Gln Gly Trp Lys 
705                 710                 715                 720 


Asn Gly Phe Asn Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Lys Lys 
                725                 730                 735     


Trp Phe Ile Glu His Arg Lys Lys Met Lys Val Asp Glu Leu Lys Ser 
            740                 745                 750         


Val Gly Leu Val Ala Lys Val Ile Pro Leu Tyr Phe Asn Glu Lys Tyr 
        755                 760                 765             


Lys Asp Ser Val Gln Pro Phe Tyr Asn Tyr Pro Phe Asn Val Gly Asp 
    770                 775                 780                 


Ile Asn Lys Pro Lys Glu Lys Asp Phe Leu Asp Asn Gly Lys Arg Arg 
785                 790                 795                 800 


Lys Leu Trp Asp Lys Lys Gln Leu Glu Phe Lys Gly Lys Thr Glu Glu 
                805                 810                 815     


Glu Lys Arg Lys Asn Pro Ser Tyr Leu Asp Phe Lys Ser Trp Lys Lys 
            820                 825                 830         


Phe Glu Arg Glu Leu Arg Leu Ile Arg Asn Gln Asp Ile Val Thr Trp 
        835                 840                 845             


Leu Met Cys Ile Glu Leu Tyr Asn Asn Gln Lys Val Glu Asn Leu Asn 
    850                 855                 860                 


Thr Gly His Ile Tyr Leu Lys Asp Ile Ile Thr Asn Val Lys Glu Glu 
865                 870                 875                 880 


Arg Asn Asn Asn Ile Leu Asn Gln Ile Lys Ser Met Gln Leu Pro Val 
                885                 890                 895     


Thr Val Tyr Glu Asn Glu Ser Ser Pro Lys Lys Lys Tyr Leu Arg Thr 
            900                 905                 910         


Ile Tyr Ile Glu Glu Asn Gly Thr Lys Leu Leu Lys Gln Gly Asn Phe 
        915                 920                 925             


Lys Ala Leu Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Val 
    930                 935                 940                 


Lys Thr Ser Ser Glu Ala Glu Ser Lys Arg Asn Pro Ile Ser Lys Leu 
945                 950                 955                 960 


Arg Val Glu His Glu Leu Arg Glu Tyr Gln Lys Ala Arg Ile Asp Ile 
                965                 970                 975     


Ile Lys Asp Met Leu Ala Leu Glu Lys Thr Leu Ile Asp Asn Tyr Asp 
            980                 985                 990         


Ser Leu Asp Thr Asp Asn Phe His  Asn Met Leu Thr Gly  Trp Leu Glu 
        995                 1000                 1005             


Leu Lys  Gly Glu Ala Ile Lys  Thr Lys Phe Asn Asn  Asp Val Lys 
    1010                 1015                 1020             


Leu Leu  Thr Ala Val Arg Asn  Ala Phe Ser His Asn  Gln Tyr Pro 
    1025                 1030                 1035             


Met Tyr  Asp Glu Asn Leu Phe  Ile Asn Ile Glu Arg  Phe Ser Leu 
    1040                 1045                 1050             


Ser Ser  Ser Arg Ile Leu Glu  Ser Lys Gly Leu Gly  Ile Ala Val 
    1055                 1060                 1065             


Lys Leu  Lys Glu Glu Val Ser  Asn Ala Ile Glu Lys  Ile Lys Asn 
    1070                 1075                 1080             


Glu Glu  Asp Ala Lys Lys Glu  Thr 
    1085                 1090     


<210>  2566
<211>  1169
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2566

Met Asp Thr Asn Ala Pro Lys Arg Tyr Thr Met Glu Thr Glu Pro Trp 
1               5                   10                  15      


Tyr Tyr Gly Gly Tyr Leu Asn Met Ala Arg His Asn Met Phe Leu Ile 
            20                  25                  30          


Ser Asn Glu Ile Val Thr Lys Leu Lys Leu Gly Phe Ala Lys Lys Lys 
        35                  40                  45              


Ala Asp Thr Ala Glu Ala Glu Pro Leu Ser Pro Lys Leu Leu Lys Asp 
    50                  55                  60                  


Asp Gly Ala Leu Pro Ser Ser Phe Leu Thr Asp Lys Asp Tyr Leu Glu 
65                  70                  75                  80  


Lys Asn Asn Pro Arg Arg Ile Tyr Ala Leu Leu Arg Arg Phe Leu Pro 
                85                  90                  95      


Leu Ala Ala Leu Phe Ala Thr Asp Thr Thr Ser Asp Glu Tyr Ser Glu 
            100                 105                 110         


Lys Glu Leu Asp Ile Ala Gln Met Ser Asp Ile Leu Lys Glu Leu Phe 
        115                 120                 125             


Ala Glu Leu Asn Arg Phe Arg Asn Asp Tyr Ser His Tyr Tyr Ser Val 
    130                 135                 140                 


Asp Arg Glu Asp Arg Arg Lys Thr Glu Leu Asp Glu Gln Val Ala Val 
145                 150                 155                 160 


Phe Leu Arg Asn Thr Phe Tyr Tyr Ala Ile His Leu Ala Arg Lys Arg 
                165                 170                 175     


Phe Glu Gly Val Ile Asp Ala Arg His Phe Gln Phe Val Glu Lys Glu 
            180                 185                 190         


Ile Ala Pro Gly Ile Val Arg Ala Asp Gly Lys Val Thr Thr Arg Gly 
        195                 200                 205             


Leu Val Phe Phe Cys Cys Leu Phe Leu Asp Lys Glu Asn Ala Phe His 
    210                 215                 220                 


Phe Ile Asn Lys Val Ser Gly Phe Lys Asn Thr Ser Thr Phe Asp Phe 
225                 230                 235                 240 


Leu Ala Thr Arg Glu Val Phe Ser Val Leu Cys Ala Lys Met Pro His 
                245                 250                 255     


Asp Arg Phe Ile Ser Glu Asn Pro Glu Gln Ala Leu Gln Leu Asp Ile 
            260                 265                 270         


Leu Asn Tyr Leu Asn Arg Ala Pro Ala Glu Leu Tyr Gln Ala Leu Ser 
        275                 280                 285             


Ala Glu Ala Lys Lys Pro Phe Gln Pro Gln Leu Gly Lys Asp Glu Arg 
    290                 295                 300                 


Tyr Asn Met Thr Gln Asn Ser Ile Pro Glu His Ile Glu Glu Glu Ser 
305                 310                 315                 320 


Tyr Glu Asn Tyr Leu Glu Ser Ile Ser Val Lys Arg Arg His Thr Asp 
                325                 330                 335     


Arg Phe Pro Glu Phe Ala Leu Lys Phe Leu Asp Arg Ser Asp Thr Phe 
            340                 345                 350         


Asp Phe Tyr Phe Gln Leu His Leu Gly Lys Ser Ile Phe Arg Ala Tyr 
        355                 360                 365             


Pro Lys Thr Leu Leu Gly Glu Thr Pro Glu Glu Pro Asn Arg Ser Ile 
    370                 375                 380                 


Ser Gly Asp Ile Lys Thr Phe Arg Asn Leu His Thr Phe Leu Gly Asn 
385                 390                 395                 400 


His Glu Glu Glu Arg Glu Gln Val Lys Ala Gln Ile Thr Ala Glu Ala 
                405                 410                 415     


Asp Phe Leu Lys Glu Phe Ser Gly Glu Tyr Ala Glu Tyr Phe Thr Gln 
            420                 425                 430         


Tyr Ala Pro His Phe His Ile Val Asn Asn Lys Ile Gly Ile Leu Pro 
        435                 440                 445             


Tyr Ser Asn Lys Lys Tyr His Glu Lys Leu Tyr Arg Pro Leu Ala Pro 
    450                 455                 460                 


Leu Ala Phe Leu Ser Val His Glu Leu Pro Lys Val Ala Leu Leu Glu 
465                 470                 475                 480 


Ile Leu Glu Pro Gly Ser Ala Ala Arg Cys Ile His Glu Cys Ile Gln 
                485                 490                 495     


Lys Ser Thr Ile Gln Val Leu Asn Asn Asp Phe Ile Glu Glu Val Lys 
            500                 505                 510         


Gln Ser Leu Ala Phe Asp Lys Glu Ile Lys Arg Gln Phe Trp Asp Asp 
        515                 520                 525             


Lys Leu Pro His Ile Glu Pro Ala Ala Ala Asp Lys Lys Ala Phe Asp 
    530                 535                 540                 


Asp Ile Arg Asn Lys Leu Asp Gln Glu Lys Lys Gly Arg Asn Arg Gln 
545                 550                 555                 560 


Ser Ala Thr Gln Asn Leu Asn Asn Arg Arg Lys Ala Leu Phe Tyr Ala 
                565                 570                 575     


Gln Tyr Val Ala Arg Val Asn Glu Arg Lys Glu Lys Leu Asn Thr Ile 
            580                 585                 590         


Leu Ala Glu Tyr Gly Leu Asn His Arg Gln Ile Pro Gly Arg Ile Leu 
        595                 600                 605             


Asp Tyr Trp Leu Arg Ile Val Glu Val Glu Thr Ala Ala Ala Ile Lys 
    610                 615                 620                 


Asn Arg Ile Arg Ala Glu Arg Lys Glu Cys Lys Gln Arg Ile Lys Ala 
625                 630                 635                 640 


Leu Asp Ala Gly Lys Gly Pro Lys Ile Gly Glu Met Ala Ser Tyr Leu 
                645                 650                 655     


Ala Arg Asp Ile Val Asn Leu Val Ile Asp Glu Lys Arg Lys Ala Lys 
            660                 665                 670         


Ile Ser Ser Phe Tyr Tyr Asp Gln Leu Gln Glu Cys Leu Ala Leu Tyr 
        675                 680                 685             


Ala Asp Ala Ala Lys Lys Gln Arg Phe Leu Asp Ile Cys Thr Lys Glu 
    690                 695                 700                 


Leu Gln Leu Phe Asp Thr Ala Asn Gly His Pro Phe Leu Ala Asp Leu 
705                 710                 715                 720 


Pro Phe Asn Lys Ile His Lys Thr Lys Asp Leu Tyr Arg Lys Tyr Ile 
                725                 730                 735     


Glu Arg Lys Gly Thr Ala Gln Arg Met Gly Lys Val Trp Asn Arg Lys 
            740                 745                 750         


Glu Lys Cys Phe Lys Ser Glu Lys Lys Glu Asp Ser Trp Leu Cys Asn 
        755                 760                 765             


Thr Phe Tyr Ser Lys Val Lys Ala Lys Asp Lys Thr Glu Ile Gln Ile 
    770                 775                 780                 


Pro Glu Ser Gly Lys Gly Val Pro Leu Ser Tyr Arg Arg Leu Ala Arg 
785                 790                 795                 800 


Glu Glu Ser Pro Leu Pro Ala Trp Leu His Ser Val Thr Lys Gly Asn 
                805                 810                 815     


Val Glu Lys Ala Asp Ser Lys Pro Ile Asp Leu Pro Leu Asn Leu Phe 
            820                 825                 830         


Asp Asp Cys Leu Asn Arg Leu Leu Thr Ala Glu Leu Gly Asp Arg Leu 
        835                 840                 845             


Gln Ala Gly Glu Lys Tyr Asn Tyr Ser Lys Leu Leu Ala Ile Trp Arg 
    850                 855                 860                 


Pro Glu Ile Gln Pro Phe Tyr Asn Trp Glu Arg Glu Tyr Val Leu Phe 
865                 870                 875                 880 


Lys Asp Glu Pro Tyr Glu Gly Arg Val Ala Phe Lys Pro Gly Ala Lys 
                885                 890                 895     


Ala Thr Phe Arg Glu Tyr Tyr Glu Pro Val Leu Asp Ser Val Tyr Arg 
            900                 905                 910         


Lys Arg Lys Arg Val Asp Pro Gln Ile Gln Glu Val Gln Val Arg Arg 
        915                 920                 925             


Val Phe Lys Lys Ala Ile Asp Glu Asn Glu Lys Gln Leu Arg Phe Tyr 
    930                 935                 940                 


Gln Ala Lys Asp Arg Ile Leu Met Leu Met Leu Asp Arg Met Ala Thr 
945                 950                 955                 960 


Glu Lys Leu Asn Ile Ser Leu Ala Glu Ile Tyr Pro Gly Ser Ala Thr 
                965                 970                 975     


Ser Pro Leu Asn Val Gln Thr Thr Ile Ser Glu Lys Ile Gly Asp Lys 
            980                 985                 990         


Tyr Asn Lys Tyr Ile Ser Tyr Thr  Arg Lys Arg Lys Asp  Tyr Ala Leu 
        995                 1000                 1005             


Phe Arg  Arg Phe Ile Thr Asp  Arg Arg Met His Gly  Leu Phe Ala 
    1010                 1015                 1020             


Trp Tyr  Thr Gln Asp Thr Ile  Ala Phe Glu Asp Leu  Lys Lys Glu 
    1025                 1030                 1035             


Leu Asp  Asp Tyr Glu Lys Leu  Arg Pro Gln Val Leu  Glu Met Cys 
    1040                 1045                 1050             


Phe Thr  Leu Glu Gln Ala Ile  Ile Ser His Met Ser  Lys Asp Glu 
    1055                 1060                 1065             


Leu Asp  Ala Met Ala Glu Lys  Ala Asn Ala Lys Ala  Ala Glu Lys 
    1070                 1075                 1080             


Asn Arg  Arg Asn Thr His Val  Glu His Gly Leu Tyr  Met Asp Trp 
    1085                 1090                 1095             


Leu Arg  Lys Tyr Ala Ile Ile  Thr Phe Glu Glu Glu  Thr Phe Tyr 
    1100                 1105                 1110             


Arg Glu  Ile Arg Asn Lys Phe  Ser His Asn Glu Phe  Pro Arg Ala 
    1115                 1120                 1125             


Asp Arg  Leu Pro Lys Ala Val  Arg Glu Ser Ser Asp  Gly Ile Thr 
    1130                 1135                 1140             


Ile Thr  His Ser Ile Val Thr  Tyr Tyr Leu Gln Glu  Leu Gln Lys 
    1145                 1150                 1155             


Leu Met  Glu Glu Lys Gly Val  Phe Thr Ala Leu 
    1160                 1165                 


<210>  2567
<211>  1272
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2567

Met Gly Lys Asn Asn His Tyr Gly Lys Lys Pro Asn Asp Ser Val Lys 
1               5                   10                  15      


Pro Gln Gln Lys Ala Asn Gln Asn Asn Gly Ser Asn Gln Gln Val Asn 
            20                  25                  30          


Asn Ala Pro Ser Tyr Pro Ser Leu Leu Glu Ala Pro Lys Leu Ile Ser 
        35                  40                  45              


Thr Ser Asn Asn Leu Arg Pro Ile Tyr Ala Ala Tyr Leu Asn Met Ala 
    50                  55                  60                  


Arg Gln Asn Leu Tyr Asn Val Leu Gln His Val Ser Val Leu Val Gly 
65                  70                  75                  80  


Tyr Asp Asn Lys Cys Asp Glu Glu Ala Met Lys Gln Met Lys Val Ile 
                85                  90                  95      


Asn Phe Ala Lys Glu Lys Ser Glu Lys Arg Ile Arg Ile Gln Lys Glu 
            100                 105                 110         


Leu Leu Tyr Ala Ile Pro Val Leu Arg Gln Met Leu Ser Val Asp Val 
        115                 120                 125             


Asp Glu Glu Lys Lys Thr Ile Thr Asp Glu Asp Val Gln Ser Leu Leu 
    130                 135                 140                 


Lys Asn Ile Val Ser Thr Ile Phe Asp Leu Arg Asn Phe Tyr Thr His 
145                 150                 155                 160 


Tyr Lys Pro Tyr Asn Ser Pro Glu Glu Ile Ser Phe Gln Lys Glu Thr 
                165                 170                 175     


Glu Arg Ala Leu Phe Pro Tyr Ile Asp Lys Ala Phe Asp Ser Ala Lys 
            180                 185                 190         


Arg Lys Val Glu Ala Ile Trp Asp Tyr Asn Lys Lys Asp Leu Arg Phe 
        195                 200                 205             


Tyr Glu Gly Ser Glu Arg Met Thr Val Thr Arg Lys Gly Lys Lys Lys 
    210                 215                 220                 


Ala Gln Lys Arg Val Lys Phe Phe Phe Asn Pro Gln Glu Glu Asp Gly 
225                 230                 235                 240 


Ser Ala Leu Ser Ala Val Gly Ile Ala Phe Leu Ile Cys Lys Leu Leu 
                245                 250                 255     


Pro Lys Gln Tyr Ser Thr Gln Phe Leu Gln Gln Ile Lys Leu Phe Glu 
            260                 265                 270         


Arg Ser Pro Tyr Lys Lys Glu His Pro Ile Phe Gly Lys Ala Asn Glu 
        275                 280                 285             


Val Met Tyr Asn Met Phe Cys Ile Asp His Ile Arg Leu Pro Lys Gly 
    290                 295                 300                 


Arg Met Glu Ser Ile Ala Asp Glu Thr Ile Leu Gly Leu Asp Met Ile 
305                 310                 315                 320 


Asn Glu Leu Arg Lys Cys Pro Phe Glu Leu Phe Lys Val Leu Ser Glu 
                325                 330                 335     


Lys Asp Gln Lys Leu Phe Glu Val Glu Ala Lys Glu Asn Glu Pro Gly 
            340                 345                 350         


Glu Lys Glu Pro Ala Val Thr Gln Leu Asn Leu Met Arg Arg Tyr Lys 
        355                 360                 365             


Asp Arg Phe Ser Tyr Leu Ala Leu Arg Tyr Ile Asp Phe Gln Lys Asp 
    370                 375                 380                 


Ile Leu Pro Gly Met Ala Phe Gln Val Ala Leu Gly Thr Tyr Arg Tyr 
385                 390                 395                 400 


His Phe Tyr Asp Lys Lys Asn Cys Ile Asp Gly Gly Glu Pro Arg Val 
                405                 410                 415     


Arg Ile Trp Gln Lys Glu Ile Asn Gly Phe Gly Arg Leu Pro Gln Ile 
            420                 425                 430         


Glu Ala Glu Arg Lys Arg Lys Tyr Gly Lys Lys Glu Asp Gly Ser Lys 
        435                 440                 445             


Gly Val Phe Ile Arg Pro Phe Asp Glu Val Thr Val Asp Thr Ala Glu 
    450                 455                 460                 


Thr Glu Pro Tyr Ile Thr Asp Arg His Ala Gly Tyr Ala Ile Thr Gly 
465                 470                 475                 480 


Asn Arg Ile Gly Ile Met Trp His Asp Asp Lys His Glu Asp Phe Lys 
                485                 490                 495     


Asn Asn Gln Tyr Leu Pro Glu Leu Pro Leu Pro Ser Val Gln Thr Glu 
            500                 505                 510         


Asn Gly Glu Lys Val Gly Ala Lys Val Ser Ile Lys Asn Leu Glu Pro 
        515                 520                 525             


Ile Cys Trp Leu Ser Thr Phe Asp Leu Pro Gly Leu Ile Phe Leu His 
    530                 535                 540                 


Leu Leu Gly Gly Lys Pro Asp Thr Val Ile Lys Ser Lys Tyr Glu Ser 
545                 550                 555                 560 


Leu Lys Lys Leu Leu Asn Tyr Ile Lys Gly Asp Glu Phe Val Asp Leu 
                565                 570                 575     


Tyr Lys Asn Glu Ile Ala Ala His Ile Glu Lys Tyr Asp Ser Ala Gly 
            580                 585                 590         


Leu Ser Lys Glu Glu Glu Thr Leu Leu Arg Lys Arg Leu Lys Ala Gln 
        595                 600                 605             


Leu Glu Pro Ile Val Phe Ser Lys Phe Asn Leu His Val Asn Asp Leu 
    610                 615                 620                 


Pro Glu Met Ile Thr Asp Ile Leu Ile Gly Lys Thr Gly His Asp Glu 
625                 630                 635                 640 


Gln Thr Glu Lys Asp His Ala Glu Lys Arg Phe Asn Glu Trp Ala Arg 
                645                 650                 655     


Asn Lys Val Glu Lys Met Ile Glu Ser Leu Glu Arg Arg Ile Lys Gly 
            660                 665                 670         


Phe Glu Lys Asp Leu Glu Lys Val Gly Thr Lys Ala Asn Arg Val Gly 
        675                 680                 685             


Lys Asp Asn Phe Val Asp Ile Arg Pro Gly Ser Leu Ala Arg Tyr Leu 
    690                 695                 700                 


Ala Lys Asp Ile Met Gly Phe Gln Pro Thr Ile Ala Asp Glu Asp Lys 
705                 710                 715                 720 


Arg Gly Thr Asp Lys Leu Thr Gly Leu Asn Phe Gln Ile Met Gln Ser 
                725                 730                 735     


Ala Ile Ala Thr Phe Glu Gly Asn Ser Leu Gln Gly Thr Gln Thr Pro 
            740                 745                 750         


Leu Trp Gln Leu Phe Lys Arg Ala Asn Leu Leu Ala Lys Asp Val Asn 
        755                 760                 765             


Gly Asp Lys Asn Pro Gln Lys His Pro Phe Leu Asn Asp Val Met Ser 
    770                 775                 780                 


Ser Thr Leu Lys Asp Thr Val Asp Leu Tyr Arg Arg Tyr Gln Glu His 
785                 790                 795                 800 


Lys Leu Lys Tyr Leu Arg Lys Ile Leu Glu Glu Asn Asn Phe Lys Glu 
                805                 810                 815     


Ala Tyr Phe Leu His Gly Asn Arg Lys Arg Tyr Ala Pro Lys Thr Leu 
            820                 825                 830         


Glu Ala Val Arg Ser Leu Ala Glu Arg Tyr Leu Asn Thr Leu Tyr Leu 
        835                 840                 845             


Pro Asp Gly Leu Phe Ala Glu Glu Ile Asn Lys Val Leu Lys Asp Lys 
    850                 855                 860                 


Tyr Lys Asp Asn Lys Ser Ile Gln Glu Ala Phe Gln Asp Pro Lys Gln 
865                 870                 875                 880 


Lys Tyr Asn Ile Ala Tyr Leu Leu Asn Val Tyr Phe Glu Gln Val His 
                885                 890                 895     


Lys Asp Cys Cys Gln Pro Phe Tyr Tyr Ser Arg Asn Gly Met Phe Lys 
            900                 905                 910         


Arg Asn Tyr Glu Leu Phe Asn Thr Leu Ala Ser Ser Lys Asn Asn Lys 
        915                 920                 925             


Val Val Lys Trp Tyr Thr Val Asp Glu Met Asn Asp Leu Thr Lys Lys 
    930                 935                 940                 


Gly Ser Gln Asp Met Ser Ile Ala Lys Arg Lys Ile Glu Glu Tyr Leu 
945                 950                 955                 960 


Asp Asn Tyr Met Val Lys Asp Glu Ile Asp Asp Thr Glu Arg Leu Ala 
                965                 970                 975     


Thr Glu Glu Glu Lys Thr Arg Lys Arg Arg Phe Leu Ile Ser Leu Leu 
            980                 985                 990         


Asn Asp Cys Lys Lys Asn Glu Lys  Ile Ile Arg Arg Tyr  Lys Thr Glu 
        995                 1000                 1005             


Asp Ile  Leu Leu Phe Leu Met  Ala Lys Lys Ile Leu  Val Gly Lys 
    1010                 1015                 1020             


Leu Lys  Thr Gln Lys Gly Arg  Thr Ile Glu Gln Ser  Glu Phe Asn 
    1025                 1030                 1035             


Glu Phe  Lys Leu Ser Ala Ile  Pro Ala Phe Lys Arg  Ala Gln Lys 
    1040                 1045                 1050             


Gln Gly  Glu Glu Glu Lys Glu  Tyr Lys Glu Leu Asn  Asp Asn Arg 
    1055                 1060                 1065             


Asp Ile  Leu Ser Lys Phe Ile  Asp Phe Asn Val Glu  Ile Val Leu 
    1070                 1075                 1080             


Arg Asp  Glu Lys Gly Arg Glu  Ile Leu Asp Asp Lys  Gly Thr Pro 
    1085                 1090                 1095             


Ile Arg  Lys Lys Val Tyr Gln  Glu His Leu Gln Leu  Lys Lys Tyr 
    1100                 1105                 1110             


Gly Asp  Phe Tyr Arg Phe Leu  Tyr Asp Thr Arg Ile  Gly Leu Leu 
    1115                 1120                 1125             


Leu Lys  Gln Leu Thr Ser Glu  Cys Ile Lys Arg Glu  Asp Ile Asp 
    1130                 1135                 1140             


Asp Glu  Leu Asp Glu Tyr Asp  Arg Asn Arg Lys Glu  Ile Phe Ala 
    1145                 1150                 1155             


Lys Ile  His Ala Ile Glu Lys  Leu Ile Ile Asn Ala  His Ala Asp 
    1160                 1165                 1170             


Gln Leu  Asp Asp Ser Asn Ala  Gly Lys Glu Gly Phe  Val Asn Glu 
    1175                 1180                 1185             


Asp Gly  Glu Pro Tyr Arg Thr  Asn Phe Arg Ser Leu  Leu Ser Leu 
    1190                 1195                 1200             


Val Glu  Ser Ile Arg Ile Asp  Arg Lys Lys Leu Thr  Lys Glu Gly 
    1205                 1210                 1215             


Glu Leu  Ile Val Glu Thr Arg  Asn Ala Phe Ser His  Asn Lys Tyr 
    1220                 1225                 1230             


Ile Glu  Gln Leu Lys Asp Ile  Ala Asp Glu Lys Gly  Leu Thr Leu 
    1235                 1240                 1245             


Pro Glu  Val Ala Lys Leu Ile  Leu Ala Asn Leu Asn  Arg Phe Ala 
    1250                 1255                 1260             


Ile Lys  Leu Gly Ile Ala Thr  Lys Lys 
    1265                 1270         


<210>  2568
<211>  1091
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2568

Met Asn Asn Lys His Val Phe Ala Ala Tyr Leu Asn Gln Ala Thr His 
1               5                   10                  15      


Asn Tyr His Leu Leu Leu Asn Asp Ile Ser Gln Lys Ile Gly Lys Thr 
            20                  25                  30          


Met Leu Glu Asp Glu Asn Leu Gln Val His Pro Val Ile Ser Leu Leu 
        35                  40                  45              


Ala Asp Ser Lys Asp Ala Arg Leu Ser Leu Arg Ala Ile Asn Ser Phe 
    50                  55                  60                  


Asn Lys Gly Phe Gly Phe Ile Glu Lys Leu Gln Arg Arg Ile Met Ala 
65                  70                  75                  80  


Tyr Arg Tyr Leu Ser Ala Lys Lys Ser Glu Pro Glu Asp Asn Ala Lys 
                85                  90                  95      


Pro Lys Lys His Ile Lys Lys Ser Gln Glu Tyr Ser Leu Leu Pro Ala 
            100                 105                 110         


Asp Tyr Ala Tyr Gln Leu Lys Ser Leu Ala Ser Thr Leu Asn Asp Glu 
        115                 120                 125             


Arg Asn His Ala Thr His Ala Tyr Leu Gln Pro Val Lys Pro Asp Ala 
    130                 135                 140                 


Asn Leu Ile Glu Phe Leu Tyr Asp Ile Phe Asp Met Ala Val Arg Val 
145                 150                 155                 160 


Cys Lys Ile Arg His Gln Ile Asp Glu Asn Asp Leu Lys His Leu Arg 
                165                 170                 175     


Arg Lys Met Arg Asn Pro Asp Lys Ser Lys Asp Ala Pro Lys Ser Ile 
            180                 185                 190         


Phe Asp Pro Lys Phe Lys Tyr Pro Phe Leu Asp Lys Gln Gly Gln Phe 
        195                 200                 205             


Thr Asp His Gly Arg Ala Phe Leu Thr Cys Leu Phe Leu Asn Lys Gln 
    210                 215                 220                 


Asp Ser Tyr Gln Phe Leu Lys Gln Leu Ser Gly Phe Lys Ser Ser Asn 
225                 230                 235                 240 


Ser Asn Thr His Lys Ala Thr Leu Arg Val Phe Ser Cys Phe Ser Ile 
                245                 250                 255     


Arg Leu Pro Asn Glu Arg Ile Asn Ser Thr Thr Asp Ala Gln Thr Leu 
            260                 265                 270         


Gly Leu Asp Met Leu Asn Glu Leu Ala Arg Cys Pro Ser Leu Leu Phe 
        275                 280                 285             


Pro Val Leu Pro Lys Ile Glu Lys Thr Ile Tyr Glu Ile Pro Val Glu 
    290                 295                 300                 


Val Asn Glu Gln Asn Asn Ser Asp Asp Gly Asn Asp Leu Leu Phe Ile 
305                 310                 315                 320 


Arg His Asp Glu Arg Phe Ile Ser Leu Met Met Arg Tyr Phe Asp Glu 
                325                 330                 335     


Thr Asn Ala Phe Glu Lys Leu Arg Phe His Ile Asp Leu Gly Asp Phe 
            340                 345                 350         


Tyr Phe Ala Ala Tyr Leu Lys Thr Leu Tyr Glu Asp Val Gln Asp Thr 
        355                 360                 365             


Arg Arg Leu Lys Gln Lys Leu His Thr Phe Ala Arg Leu Asn Glu Val 
    370                 375                 380                 


Glu Asn Thr Ala Ile Pro Ala Glu Trp Gln Thr Leu Ile Arg Asp Asn 
385                 390                 395                 400 


Arg Glu Ile Thr Glu Thr Asp Leu Asn Pro Tyr Leu Val Asn Thr Thr 
                405                 410                 415     


Pro His Tyr His Leu Leu Asp Asp Asn Ile Ala Leu Lys Ile Val Gly 
            420                 425                 430         


Pro Asn Thr Val Ile Tyr Pro Lys Leu Thr Pro His Asp Ser Ile Glu 
        435                 440                 445             


Asn Arg Tyr Lys Ser Pro Glu Asn Gln Gln Pro Asp Phe Trp Leu Ser 
    450                 455                 460                 


Lys His Glu Met Leu His Leu Ala Phe Tyr Gln Leu Leu Arg Gln Lys 
465                 470                 475                 480 


His Thr Gln Leu Asn Arg Gly Gln Ile Glu Asp Thr Val Phe Ala Gln 
                485                 490                 495     


Tyr Lys Gln Ala Leu His His Cys Leu Asp Gln Leu Ala Glu Asn Pro 
            500                 505                 510         


Glu Arg Tyr Thr Ser Lys Glu Ala Ile His Asp Leu Ala Gln Gln Tyr 
        515                 520                 525             


Thr Tyr Ser Pro Leu Lys Gln Ala Met Met Leu Asp Glu Ile Pro Lys 
    530                 535                 540                 


Val Val Arg Asp Ala Leu Ile Lys Lys Asp Ser Arg Tyr Gln Asn Ser 
545                 550                 555                 560 


Ala Leu Thr Ala Ile Ser Thr Leu Ile Asn Ile Gly Glu Lys Arg Leu 
                565                 570                 575     


Asp Ala Leu Lys Arg Ser Thr Ser Thr Asp Lys Lys Asp Lys Ser Thr 
            580                 585                 590         


Arg Pro Gly Asp Lys Lys Gln Arg Pro Val Lys Ala Gly Leu Met Gly 
        595                 600                 605             


Glu His Leu Ala Glu Asp Ile Val Arg Phe Gln Pro Ala Gln Asp Asp 
    610                 615                 620                 


Ser Asp Asn Lys Gly Lys Pro Thr Ser Leu Ile Val Ala Glu Leu Gln 
625                 630                 635                 640 


Ala Arg Leu Ala Phe Tyr Gly Arg Asp Lys Ala Gln Leu Pro Ala Leu 
                645                 650                 655     


Cys Lys Ala Met Lys Leu Ile Asp Asn Val Asp Thr Ser Lys Asn His 
            660                 665                 670         


Pro Phe Leu Ala Ala Val Leu Lys Glu Asn His Ala Gly Ile Ile Gly 
        675                 680                 685             


Phe Tyr Gln Ser Tyr Tyr Arg Ala Arg Ala His Tyr Leu Gln Arg Val 
    690                 695                 700                 


Glu Ala Asp Ile Thr Gln Asn Thr Ser His Ile Ser Arg Tyr His Trp 
705                 710                 715                 720 


Leu Lys Thr Pro Thr Arg Asp Lys Pro Asp Phe Ser Ile Lys Ser His 
                725                 730                 735     


Val Lys Lys Leu Lys Ala Gln Pro Val Asn Leu Pro Arg Gly Leu Phe 
            740                 745                 750         


Leu Pro Tyr Ile Lys His Ala Leu Leu Gln Leu Asn His Asp Thr Leu 
        755                 760                 765             


Thr Pro Ala Ile Glu Lys Ser Ala Thr Leu Asn Thr Ser Tyr Leu Ile 
    770                 775                 780                 


Ala Leu Tyr Tyr Gln His Val Leu Gln Asp Lys Pro Gln Ala Val Tyr 
785                 790                 795                 800 


Glu Lys Pro Arg Glu Tyr Lys Ile Ile Ala Gln Thr Phe Asp Asn Arg 
                805                 810                 815     


Thr Asn Gln Phe Lys Pro Leu Pro Ala His Pro Thr Gln Thr Gln Gln 
            820                 825                 830         


Ala Tyr Gly Thr Thr Asn Ala Leu His Thr Lys Ile Lys Gln His Leu 
        835                 840                 845             


Gln Ala Lys Tyr Pro Asp Glu Asp Lys Thr Gln Gln Leu Ala Ala Tyr 
    850                 855                 860                 


Arg Lys Phe Glu Gln Tyr Glu Lys Asn Ile Arg Gln Ile Arg Thr Gln 
865                 870                 875                 880 


Asp Gln Val Leu Phe Leu Ala Cys Gln Gln Leu Leu Ala Leu Asn His 
                885                 890                 895     


Gly Leu Asn Gln Glu Ile Ser Gln Leu Lys Leu His Gln Leu Asp Lys 
            900                 905                 910         


Thr Leu Leu Asp Lys Gln Thr His Tyr Gln Leu His Ile His Gly Lys 
        915                 920                 925             


Thr Ile Ser Gln Ala Gln Ile Arg Ile Lys Lys Ile Gly Glu Phe Arg 
    930                 935                 940                 


Arg Phe Leu Lys Asp Arg Arg Leu Lys Gly Leu Leu Ser Tyr Tyr Gly 
945                 950                 955                 960 


Gln His Asp Ile Pro Arg Glu Val Ile Ala Lys Glu Leu Glu Glu Tyr 
                965                 970                 975     


Gln His Cys Arg Leu Lys Val Phe Glu Arg Leu His Ala Phe Glu Gln 
            980                 985                 990         


Phe Ser Tyr Gln His Phe Gly Leu  Asp Ala Gln Tyr Gln  Gly Ser Glu 
        995                 1000                 1005             


His Gly  Gln Leu Leu Ser Ala  Tyr Phe Lys Ala Asn  Pro Gln Ala 
    1010                 1015                 1020             


Asn His  Glu Ala Gln Met His  Cys Met Leu Val Leu  Arg Asn Ala 
    1025                 1030                 1035             


Phe Ala  His Asn Gln Tyr Pro  Met Pro Gln Ser Lys  Tyr Pro Leu 
    1040                 1045                 1050             


Ala Asn  Ala Met Leu Thr Gln  Ala Gln Gln His Leu  Thr Gln Ser 
    1055                 1060                 1065             


Gly Ala  Pro Gln Val Ala Gln  Tyr Leu Leu Gln Gln  Val Glu Ala 
    1070                 1075                 1080             


Phe Tyr  Pro Asn Pro Ile Thr  Thr 
    1085                 1090     


<210>  2569
<211>  1156
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2569

Met Glu Leu Ser Gln Ala Val Leu Ala Ala Phe Tyr Asn Asp Ala Arg 
1               5                   10                  15      


Leu Asn Ile Leu Ala Cys Leu Asn Asp Ile Arg Asn Lys Gln Gly Leu 
            20                  25                  30          


Ser Leu Met Gln Gly Asp Glu His Ile Val Ser Ala Phe Tyr Asp Leu 
        35                  40                  45              


Ser Gln Ile Leu Thr Asn Gly Thr Pro Glu Glu Ser Ser Ala Leu Ile 
    50                  55                  60                  


Lys Asp Leu Arg Tyr Arg Phe Pro Phe Leu Asp Ala Arg Thr Asp Ala 
65                  70                  75                  80  


Ser Glu Lys Asn Lys Gly Phe Thr Pro Leu Pro Glu Asn Tyr His Gln 
                85                  90                  95      


Ile Leu Glu Trp Met Phe Lys Leu Leu Asn Gly Leu Arg Asn Ser Val 
            100                 105                 110         


Val His Pro Cys Asp Gln Pro Phe Leu Ile Asp Ile Glu Leu His Lys 
        115                 120                 125             


Asn Ile Phe Phe Leu Leu Asn Asp Ile Tyr Asp Asp Gly His Arg Leu 
    130                 135                 140                 


Leu Lys Thr Arg Phe Asp Trp Thr Thr Asn Asp Ile Lys Pro Leu Leu 
145                 150                 155                 160 


Arg Tyr Asp Gln Arg Gly Lys Leu Lys Ile Lys Arg Phe Ser Phe Val 
                165                 170                 175     


Leu Cys Ser Asp Pro Lys Lys Arg Ser Asn Ser Pro Val Leu Gly Gln 
            180                 185                 190         


Lys Lys Val Phe Tyr Ser Phe Gly His Val Leu Phe Cys Ser Leu Phe 
        195                 200                 205             


Leu Asp Lys Ser Gln Ser Ala Asp Leu Ile Ser His Phe Trp Glu Ser 
    210                 215                 220                 


Gly His Gly Lys Phe Trp Gln Asp Asn Lys Tyr Arg Glu Met Ile Lys 
225                 230                 235                 240 


Glu Leu Ile Ser Phe Tyr Arg Val Arg Leu Pro Leu Leu Arg Leu Lys 
                245                 250                 255     


Ala Asp Ser Gln Thr Thr Leu Thr Ile Asp Ala Leu Ser Glu Leu Ser 
            260                 265                 270         


Arg Cys Pro Arg Pro Leu Leu Gly Ala Leu Ser Gln Gln Asp Lys Asn 
        275                 280                 285             


Lys Phe Arg Glu Val Val Asp Asp Val Asp Thr Asp Asn Asn Ser Gln 
    290                 295                 300                 


Gln Ser Ser Thr Tyr Leu Leu Ala Arg Ser His Gln Asn Arg Phe Ile 
305                 310                 315                 320 


Pro Leu Met Met Ser Phe Phe Glu Gln Ser Ala Asn Ser Arg Leu Arg 
                325                 330                 335     


Phe Ala Ile Asp Phe Gly His Phe Tyr Phe Asn Val Arg Leu Lys Ser 
            340                 345                 350         


Gly Ser His Phe Thr Asp Asn Glu Pro Arg Val Arg Arg Ile Gly Gln 
        355                 360                 365             


Lys Ile Ile Gly Tyr Gly His Leu Gln Ala Val Glu Lys Pro Ile Ile 
    370                 375                 380                 


Trp Gln Gln Leu Gln Asp Asn Phe Thr Ser Ser Asn Asp Glu Ala Ile 
385                 390                 395                 400 


Asn Ala Lys Ala Ser Ile Ser Lys Gln Ser Asn Thr Asp Glu Gln Leu 
                405                 410                 415     


Gln Leu Lys Pro Tyr Leu Val Lys Thr Phe Ala His Tyr His Phe Asp 
            420                 425                 430         


Glu His Lys Ile Gly Phe Lys Leu Val Gln Asp Asn Asp Leu Ser Ala 
        435                 440                 445             


Phe Pro Asp Leu Pro Ala Asp Ile Asp Val Thr Glu Pro Ile Lys Leu 
    450                 455                 460                 


Thr Lys Ile Ser Gly Gln Leu Met Gln Pro Asp Phe Trp Met Ser Pro 
465                 470                 475                 480 


Ala Gln Met Leu His Leu Ser Phe Tyr Tyr Tyr Leu Tyr Glu Gln Tyr 
                485                 490                 495     


Pro Asp Ser Ala Thr Asn Ser Asn Ser Lys Ser Val Asp Val Leu Phe 
            500                 505                 510         


Asn Ile Tyr Arg Gly Gly Ile Gln Arg Leu Phe Gln Asn Leu Phe Glu 
        515                 520                 525             


Ala Ser Pro Ser Leu Ser Gly Glu Pro Phe Ser Glu Glu Arg His Gln 
    530                 535                 540                 


Ala Val Gln Ala Tyr Ile Asn Asn Tyr Phe Asn Thr Asp Asp Phe Thr 
545                 550                 555                 560 


Ile Ser Met Ala Asp Leu Pro Lys Val Ile Val Arg His Leu Leu Gly 
                565                 570                 575     


Ala Glu Asp Lys Pro Ile Ser Lys Leu Gln Ile Ile Gln Arg Ala Lys 
            580                 585                 590         


Gln Leu Lys Glu Lys Thr Glu Gln Lys Ile His Gln Leu Glu His Leu 
        595                 600                 605             


Gln Asn Ala Tyr Lys Lys Arg Gly His Lys Asp Phe Arg Pro Ile Lys 
    610                 615                 620                 


Cys Gly His Ile Gly Asp Phe Leu Ser Glu Asp Leu Ile Arg Phe Gln 
625                 630                 635                 640 


Ala Val Asn Lys Ala Gln Ala Asp Gly Gly Lys Leu Asn Ser Gln Gln 
                645                 650                 655     


Tyr Gln Ile Leu Gln Ala Thr Leu Ala Tyr Tyr Gly Lys Tyr Ile Asp 
            660                 665                 670         


Gln Pro Pro Lys Val Ile Asp Leu Phe Lys Asn Phe Gly Leu Leu Asp 
        675                 680                 685             


Gly Glu Phe Arg His Pro Phe Leu Tyr Lys Leu Gly Leu Gln Asn Asn 
    690                 695                 700                 


Pro Glu Lys Tyr Gln Gly Leu Leu Ala Phe Tyr Glu Asp Tyr Leu Val 
705                 710                 715                 720 


Ala Arg Lys Asn Tyr Leu Lys Asp Tyr Ile Lys Glu Thr Glu Ala Ser 
                725                 730                 735     


Asp Ser Pro Lys Ala Ala His Trp Leu Arg Leu Lys Gln Ile Ser Thr 
            740                 745                 750         


Leu Gln Gly Trp Phe Asn Glu Asn Leu Thr Ser Asn Gln Lys Leu Lys 
        755                 760                 765             


Gln Pro Leu Pro Ile Ala Lys Asn Phe Phe Tyr Gln Pro Ile Leu Lys 
    770                 775                 780                 


Leu Leu Ala Asp Val Leu Lys Gln Gly Pro Glu Asp Leu Gln Lys Asn 
785                 790                 795                 800 


Gly Met Gln Cys Phe Ile Arg Gly Gly Lys Glu Val Gln Ile Arg Pro 
                805                 810                 815     


Ala Ile Ser Trp Phe Ile His Tyr Tyr Gln Gln Ser Lys Asp Asp Asn 
            820                 825                 830         


Val Gln Glu Met Tyr Gly Phe Lys Arg Asn His Glu Val Phe Asp Asn 
        835                 840                 845             


Phe Leu Asp Arg Arg Gly Asn Asn Ser Phe Lys Glu Arg Lys Ile His 
    850                 855                 860                 


Phe Leu Ser Glu Asp Glu Arg Lys Ser His Leu Pro Glu Ile Arg Gln 
865                 870                 875                 880 


Lys Ile Gln Ile Leu Asp Gln Gln Ile Thr Glu Gln Asp Lys Gln Asn 
                885                 890                 895     


Lys Thr Asp Lys Ala Lys Gln Tyr Tyr Lys Leu Ile Asn Asp Leu Lys 
            900                 905                 910         


Ala Tyr Lys Lys Gln Glu Lys Val Ile Arg His Thr Ala Thr Gln Asp 
        915                 920                 925             


Ile Leu Leu Ser Leu Tyr Val Arg Gln Asn Leu Lys His Leu Met Gln 
    930                 935                 940                 


Asn Ser Asp Asp Ile Asn Trp Lys Leu Asn Asn Ile Glu Asn Ser Leu 
945                 950                 955                 960 


Leu Asn Glu Ser Ile Tyr His Cys Phe Ser Ile Pro Asp Ser Thr Lys 
                965                 970                 975     


Lys Leu Phe His Pro Asp Cys Lys Ile Arg Lys Leu Gly Glu Leu Arg 
            980                 985                 990         


Leu Leu Ala Arg Asp Lys Arg Leu  Pro Ser Leu Leu Glu  Tyr Tyr Pro 
        995                 1000                 1005             


Ala Glu  Glu Thr Glu Ile Asn  Gln Ala Glu Ile Arg  Ala Glu Leu 
    1010                 1015                 1020             


Asn Asp  Tyr Arg Arg Ala Arg  Ile Asp Ile Met Arg  Ala Val His 
    1025                 1030                 1035             


Thr Leu  Glu Lys Lys Ile Ser  Ser Val Cys Gly Leu  Pro Glu Lys 
    1040                 1045                 1050             


Gly Ser  Val Pro Ile Asp Arg  Glu Ala Phe Phe Gly  Lys Ala Arg 
    1055                 1060                 1065             


His Gly  Glu Tyr Leu Tyr His  Leu Cys Val Ala Asn  Ser Asp Lys 
    1070                 1075                 1080             


Ile Gly  Phe Lys Gln Glu Asp  Phe Tyr Lys Ala Leu  Leu Ile Arg 
    1085                 1090                 1095             


Asn Ala  Phe Ala His Ser Glu  Tyr Pro Lys Thr Glu  Tyr Phe Pro 
    1100                 1105                 1110             


Glu Ile  Val Ala Ala Thr Arg  Ser Glu Ala Ile Pro  Glu Asn Pro 
    1115                 1120                 1125             


Ala Leu  Asn Arg Asn Ile Ala  Leu Arg Leu Ala Glu  Glu Leu Lys 
    1130                 1135                 1140             


Arg Leu  Tyr Gln Pro Trp Leu  Asp Phe Leu Ser Gly  Ala 
    1145                 1150                 1155     


<210>  2570
<211>  1131
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2570

Met Glu Lys Thr Ile Glu Asn Gln Thr Gln Ser Lys Arg Thr Leu Asn 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Asp Glu Glu Lys Ile Thr Thr Ser Phe Leu Val Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Arg Gln Ser Leu Val Tyr Ser Asn Leu Thr 
65                  70                  75                  80  


Arg Tyr Met His Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Asp 
                85                  90                  95      


Asp Glu Arg Asp Lys Ala Glu Asn Tyr Gly Lys Asp Phe Gly Asn Leu 
            100                 105                 110         


Thr Asp Thr Leu Lys Glu Ile Phe Lys Glu Leu Asn Glu Phe Arg Asn 
        115                 120                 125             


Asp Tyr Ser His Tyr Tyr Ser Thr Glu Lys Lys Asp Lys Arg Lys Thr 
    130                 135                 140                 


Ile Val Ser Asp Lys Leu Lys Asn Phe Leu Asn Ile Asn Tyr Thr Arg 
145                 150                 155                 160 


Ala Ile Lys Tyr Thr Lys Ser Arg Phe Ile Asn Val Phe Ser Asp Asn 
                165                 170                 175     


Asn Phe Cys Leu Ala Glu Glu Ala Lys His Val Glu Asn Asp Asn Thr 
            180                 185                 190         


Ile Thr Gln Asp Gly Ile Val Phe Phe Thr Ser Met Phe Leu Asp Arg 
        195                 200                 205             


Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile Ile Gly Leu Lys Gly Thr 
    210                 215                 220                 


Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Thr Leu Met Ala Phe Cys 
225                 230                 235                 240 


Val Asn Leu Pro His Asp Lys Phe Val Ser Glu Asn Ser Glu Gln Gln 
                245                 250                 255     


Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu 
            260                 265                 270         


Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln His Phe Leu Pro Lys Leu 
        275                 280                 285             


Asp Asp Glu Gln Ile Asp Asn Val Leu Glu Asn Ser Val Pro Tyr Thr 
    290                 295                 300                 


Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn Ile Thr Lys Lys Val Arg 
305                 310                 315                 320 


Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu Lys Phe Ile Asp Gln Lys 
                325                 330                 335     


Lys Leu Phe Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val 
            340                 345                 350         


Leu Asp Glu Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Lys Arg Thr 
        355                 360                 365             


Val Thr Glu Asn Thr Lys Ala Phe Gly Met Leu Gln Asp Leu Asn Asp 
    370                 375                 380                 


Glu Glu Asn Val Leu Asn Lys Ile Asn Thr Gly Glu Ser Lys Ala Lys 
385                 390                 395                 400 


Phe Asp Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Thr Lys Asn 
            420                 425                 430         


Thr Asp Asn Lys Ile Lys Ser Asn Leu Leu Gln Pro Leu Pro Glu Ala 
        435                 440                 445             


Phe Leu Ser Ile Asn Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
    450                 455                 460                 


Glu Gln Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn 
465                 470                 475                 480 


Asn Ser Lys Ile Leu Asn Lys Glu Phe Ile Lys Ala Ile Lys Leu Lys 
                485                 490                 495     


Leu Asn Asp Leu Asp Val Phe Tyr Lys Arg Ser Gln Gly Arg Lys Gln 
            500                 505                 510         


Lys His Ala Tyr Leu Thr Lys Asp Lys Lys Tyr Asp Asn Glu Lys Ile 
        515                 520                 525             


Asn Glu Leu Lys Asn Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu 
    530                 535                 540                 


Tyr Asn Leu Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp 
545                 550                 555                 560 


Leu Asn Ile Ala Asp Val Gln Ala Lys Asn Ala Ile Ser Asp Arg Ile 
                565                 570                 575     


Lys Leu Met Lys Arg Asp Cys Ile Asn Arg Leu Lys Ser Met Lys Lys 
            580                 585                 590         


Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp 
        595                 600                 605             


Ile Val Asp Met Ile Ile Asp Glu Glu Lys Lys Lys Lys Ile Thr Ser 
    610                 615                 620                 


Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Lys 
625                 630                 635                 640 


Glu Lys Lys Glu Leu Phe Ile Leu Ile Cys Asn Asn Glu Leu Lys Leu 
                645                 650                 655     


Asn Asp Asp Asp Gly His Pro Phe Phe Lys Asn Ile Asn Phe Ser Asn 
            660                 665                 670         


Tyr Lys Tyr Thr Ser Glu Ile Tyr Gln Lys Tyr Leu Glu Glu Lys Gly 
        675                 680                 685             


His Lys Met Val Lys Glu Tyr Asn Pro Arg Lys Glu Asn Tyr Val Glu 
    690                 695                 700                 


Lys Asp Lys Ser Trp Leu Glu Ile Asn Phe Tyr Lys Lys Glu Trp Asn 
705                 710                 715                 720 


Glu Asn Ala Lys Lys Asp Leu Thr Val Val Lys Leu Pro Asp Asp Lys 
                725                 730                 735     


Ser Lys Ile Pro Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser 
            740                 745                 750         


Phe Glu Asn Trp Phe Lys Tyr Val Thr Asn Gly Lys Glu Thr Thr Asp 
        755                 760                 765             


Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp Glu Thr Leu 
    770                 775                 780                 


Lys Glu Leu Leu Lys Lys Glu Leu Ser Lys Asn Asn Ile Glu Phe Lys 
785                 790                 795                 800 


Glu Glu Asp Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Asp Lys Cys 
                805                 810                 815     


Arg Asn Asp Lys Thr Gln Lys Phe Tyr Ser Ala Glu Arg Glu Tyr Thr 
            820                 825                 830         


Phe Glu Glu Glu Lys Leu Asn Phe His Ile Asn Thr Lys Ser Lys Phe 
        835                 840                 845             


Glu Glu Tyr Ile Asn Pro Glu Phe Ala Glu Lys Val Phe Arg Leu Lys 
    850                 855                 860                 


Asn Gln Asn Arg Glu Lys Asp Asn Ile Ser Gly Arg Arg Leu Pro Pro 
865                 870                 875                 880 


Leu Lys Met Lys Glu Val Thr Lys Asn Met Val Lys Arg Ile Gly Asn 
                885                 890                 895     


Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Leu Met Leu 
            900                 905                 910         


Leu Met Phe Glu Lys Leu Val Asp Asn Asn Leu Lys Leu Lys Leu Glu 
        915                 920                 925             


Asn Val Asp Lys Leu Leu Asn Glu Ser Ile Glu Ile Asn Gln Ser Ile 
    930                 935                 940                 


Ser Gly Lys Leu Ser Phe Asp Asp Ser Gly Asp Asn Glu Asn Lys Lys 
945                 950                 955                 960 


Asp Arg Ala Ile Ile Cys Arg Asn Ile Thr Glu Thr Arg Lys Arg Lys 
                965                 970                 975     


Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Glu Glu Glu  Asn Ile Pro Ile Glu  Lys Ile Lys 
        995                 1000                 1005             


Ile Glu  Leu Asp Thr Tyr Ser  Lys Ala Lys Asp Val  Val Phe Asp 
    1010                 1015                 1020             


Leu Ile  Phe Asp Leu Glu Arg  Ala Ile Ile Asn Lys  Asp Glu Asn 
    1025                 1030                 1035             


Arg Ile  Lys Glu Leu Asn Lys  Asp Lys Asn Gly Val  Ile Gln Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Phe Trp Leu  Leu Glu Lys 
    1055                 1060                 1065             


Asn Leu  Ile Thr Glu Gln Glu  Phe Thr Phe Met Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Ile  Phe Ser His Asn Gln  Phe Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Leu Phe  Ile Lys Asn Trp Asn  Glu Asn Glu Phe Ala  Lys Gln Ile 
    1100                 1105                 1110             


Leu Asn  Val Tyr Asn Gln Lys  Asn Asn Asn Leu Ile  Lys Ser Ile 
    1115                 1120                 1125             


Lys Asp  Ile 
    1130     


<210>  2571
<211>  1197
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2571

Met Ser Asn Asn Phe Arg Thr Gln Ser Thr His Arg Pro Pro His Leu 
1               5                   10                  15      


Gln Lys Thr Thr Pro Pro Ser Lys Leu Glu Thr Trp Thr Gly Gly Lys 
            20                  25                  30          


Arg Pro Glu Leu Ala Val Phe Tyr Asn Val Ala Tyr Phe Arg Ile Ala 
        35                  40                  45              


Gly Met Leu Ser His Tyr Leu Asn Lys Thr His Glu His Asp Lys Asp 
    50                  55                  60                  


Ala Leu Glu Leu Leu Phe Lys Lys Val Val Ser Gly Glu Asp Gln Leu 
65                  70                  75                  80  


Ser Asp Ala Val Cys Ser Lys Leu Arg Asp Tyr Leu Trp Lys Ser Tyr 
                85                  90                  95      


Thr Thr Gln Gln Glu Asn Ser Ser Gly Tyr Ala Leu Asn Gln Glu Asp 
            100                 105                 110         


Arg Asp Leu Val Leu Leu Met Leu Gln Lys Leu Gln Asp Val Arg Asn 
        115                 120                 125             


Phe Gln Ser His Val Trp His Asp Asn Arg Ala Leu Val Phe Pro Met 
    130                 135                 140                 


Glu Leu Cys Ala His Ile Glu Arg Met His Glu Ala Ala Ile Met Ala 
145                 150                 155                 160 


Gln Gly Ile Asp Met Ala Ser Ala Val Val Thr Tyr His Asp Asn Tyr 
                165                 170                 175     


Lys Val Tyr Asp Ser Lys Met Arg Phe Asn Gln Gly Arg Lys Asp Leu 
            180                 185                 190         


Gln Ala Phe Phe Asp Arg Trp Asp Thr Asp His Tyr Ile Thr Gln Glu 
        195                 200                 205             


Gly Arg Ile Phe Phe Leu Ser Phe Phe Leu Thr Arg Ser Glu Met Ala 
    210                 215                 220                 


Arg Leu Leu Gln Gln Ser Lys Gly Ser Lys Arg Asn Asp Lys Pro Glu 
225                 230                 235                 240 


Phe Lys Ile Lys His Ala Ile Tyr Arg Tyr Phe Thr His Arg Asp Ala 
                245                 250                 255     


Ala Ser Arg Asn His Tyr Gly Leu Asn Asp Asn Ile Leu Ser Glu Leu 
            260                 265                 270         


Pro Asn Glu Gln Arg Ala Gln Ile Met Ala Ala Arg Gln Val Tyr Lys 
        275                 280                 285             


Ile Ile Asn Tyr Leu Asn Asp Ile Pro Tyr Arg Ser His Asp Pro Ala 
    290                 295                 300                 


Leu Phe Pro Leu Phe Leu Ala Asp Gly Thr Glu Ala Leu Asp Glu His 
305                 310                 315                 320 


Gly Leu Leu Gln Trp Lys Gln Glu Thr Asp Phe Leu Pro Glu Ile Thr 
                325                 330                 335     


Ala Lys Ala Arg Lys Val Pro Ala Leu Ser Glu Thr Glu Arg Phe Gly 
            340                 345                 350         


Val Arg Gly Arg Lys Ala Thr Lys Ala Ile Asp Asp Arg Thr Leu Glu 
        355                 360                 365             


Val Glu Arg Gly Phe Glu Leu Gln Trp Val Gly Asn Asp Arg Tyr Asn 
    370                 375                 380                 


Phe Thr Ile Pro Thr Arg His Phe His Arg Cys Ala Leu Asp Ala Ile 
385                 390                 395                 400 


Arg Asn Gly Asp Lys Gly Ala Thr Phe Ala Asp Arg Leu Lys Val Phe 
                405                 410                 415     


Ile Gly Asp Arg Glu His Leu Leu Asp Arg Leu His Lys Glu Phe Thr 
            420                 425                 430         


Ile Leu Pro Leu Arg Gln Ala Asp Phe Thr Leu Glu Lys Glu Leu Asp 
        435                 440                 445             


Glu Tyr Tyr Lys Phe Arg Leu Arg Gly Asp Gly Lys Leu Thr Lys Ser 
    450                 455                 460                 


Leu Gly Gln Trp Leu Asp Ala Ile Asp Arg Gln Asn Val Arg Lys Tyr 
465                 470                 475                 480 


Pro Glu Ala Leu Ala Lys Leu Lys Glu Gln Leu Arg Asn Ser Pro Ile 
                485                 490                 495     


Ile Leu Thr Tyr His Gly Leu Ser Phe Thr Asn Glu Arg Lys Pro Arg 
            500                 505                 510         


Ala Ala Asp Arg Phe Thr Glu Phe Ala Val Lys Tyr Leu Ile Asp His 
        515                 520                 525             


Arg Val Val Pro Asp Trp Leu Trp Gly Ile Glu His Phe Glu Pro Val 
    530                 535                 540                 


Thr Glu Glu Lys Leu Asp Arg Arg Ser Gly Ala Thr Met Lys Arg Glu 
545                 550                 555                 560 


Val Leu Lys Arg Lys Ile Thr Tyr His Asp His Val Pro Glu Lys Asp 
                565                 570                 575     


Glu Lys Asp Ile Gly Ile Leu Asn Pro Glu Leu Ser Ser Glu Pro Arg 
            580                 585                 590         


Leu Ala Ile Ser Asp Ser His Ala Leu Val Lys His Arg Gln Asp Asp 
        595                 600                 605             


Arg Ile Leu Phe Arg Ile Gly His Arg Ala Leu Lys Asn Ile Leu Ile 
    610                 615                 620                 


Ala His Gln Gln Gly Lys Pro Val Arg Asn Leu Leu Pro Arg Leu Ile 
625                 630                 635                 640 


Asp Asp Leu Gln Leu Val Asn Gly Ala Arg Arg Asn Gly Thr Thr Leu 
                645                 650                 655     


Asn Leu Ser Thr Leu Lys Leu Phe Asp Lys Asn Ser Leu Ala Glu Ala 
            660                 665                 670         


Thr Arg Asn Ala Ile Ala Pro Ile Ala Ala Glu Ser Ile Gln Arg Thr 
        675                 680                 685             


Ala Ala Leu Ala Lys Ala Leu His Gly Asn Thr Asp Arg Met Gly Gln 
    690                 695                 700                 


Arg Thr Pro Gly Arg Ile Ala Ser Leu Ile Thr Glu Leu Glu Arg Phe 
705                 710                 715                 720 


Gly Val Pro Asp Ser Glu Met Pro Arg Met Ser Arg Asp Ser Lys Asn 
                725                 730                 735     


Arg Gln Ile Met Arg Cys Tyr Lys Tyr Phe Asp Trp Lys Tyr Leu Asn 
            740                 745                 750         


Asp Ala Gln Tyr Lys Phe Leu Arg Gln His Glu Tyr Gln Asn Met Ser 
        755                 760                 765             


Ile Tyr His Tyr Met Leu Trp Asp Ile Arg Lys Asp Arg Gly Leu Ala 
    770                 775                 780                 


His Gly Lys Tyr Gly Asp Leu Leu Lys Gly Ile Thr Pro His Met Pro 
785                 790                 795                 800 


Pro Thr Val Gln Gln Leu Leu Phe Lys Ser Arg Asp Leu Asn Asp Leu 
                805                 810                 815     


Leu Arg Asn Thr Ala Thr Ala Thr Ile Val Leu Leu Asn Ser Trp Lys 
            820                 825                 830         


Glu Glu Leu Leu Lys Pro Ser Ile Asp Asp Glu Arg Leu Asn Ala Ile 
        835                 840                 845             


Met Ser Arg Leu Gly Val Pro Val Ser Glu Ala Asn Arg Val Phe Asn 
    850                 855                 860                 


Gln His Leu Pro Ile Ala Ile His Pro Met Leu Pro Val Arg Ala Tyr 
865                 870                 875                 880 


Tyr Ser Ala Gln Asp Ile Ser Lys Leu Ser Leu Ser Arg Ser Ile Trp 
                885                 890                 895     


Lys Asn Lys Glu Glu Arg Gln Pro Leu Val Asp Glu His Tyr Ala Tyr 
            900                 905                 910         


Glu Asp Tyr Leu Ala Gln Tyr Ala Phe Val Pro Glu Arg Lys Pro Leu 
        915                 920                 925             


Arg Lys Arg Val Ile Gly Gln Met Asn Glu Leu Ile Thr Glu Asp Ala 
    930                 935                 940                 


Leu Leu Trp Lys Cys Ala Met Thr Tyr Leu Asn Asn Ala Ser Val Val 
945                 950                 955                 960 


Val Arg Asp Val Ile Lys Gln Ala Leu Val Arg Gly Asp Gln Ala Met 
                965                 970                 975     


Lys Val Gly Ser Leu Phe Asp Ala Thr Ile Ser Ile Pro Leu Gln Pro 
            980                 985                 990         


Leu Glu Val Lys Asn Gln Gly Leu  Gly Lys Leu Leu Gln  Glu Glu Phe 
        995                 1000                 1005             


Asp Ser  Leu Lys Ile Ala Ala  Ile Glu Val Asp Ile  Lys Phe Lys 
    1010                 1015                 1020             


Gln Leu  Asp Asp Tyr Leu Phe  Met Glu Ser Arg Pro  Gln Leu Leu 
    1025                 1030                 1035             


Lys Ala  Ala Cys Gln Val Val  Arg Arg Phe Val Ala  Ser Gly Lys 
    1040                 1045                 1050             


Pro Asp  Glu Val Asn Val Val  Glu Glu Asn Gly Arg  Lys Lys Tyr 
    1055                 1060                 1065             


Ser Met  Pro Tyr Gly Val Ile  Tyr Gln Glu Ile Gln  Arg Ile Gln 
    1070                 1075                 1080             


Asn Gln  Ala Val Ser Trp Ala  Gly Thr Leu Leu Ala  Asn Glu Glu 
    1085                 1090                 1095             


Arg Val  Val Arg Ala Met Thr  Thr Glu Glu Arg Asp  Ser Phe Gly 
    1100                 1105                 1110             


Ala Gly  His Val Lys Asp Asp  Ser Gln Phe Ala Tyr  Ile Gly Phe 
    1115                 1120                 1125             


Ala Asp  Val Cys Val Lys Leu  Gly Leu Ser Pro Ser  Leu Thr Thr 
    1130                 1135                 1140             


Met Val  Arg Ser Ile Arg Asn  Thr Thr Leu His Ala  Asp Leu Pro 
    1145                 1150                 1155             


Met Gly  Trp Thr Tyr Glu Glu  Tyr Glu Lys Asp Pro  Glu Leu Phe 
    1160                 1165                 1170             


Ala Val  Leu Gly His Val Pro  Lys Gln Pro Arg Ala  Pro Lys Pro 
    1175                 1180                 1185             


Ser Glu  Val Gln Ala Glu Glu  Gly Lys 
    1190                 1195         


<210>  2572
<211>  1147
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2572

Met Glu Ile Ala Pro Gln Gln Ser Glu Thr Gln Lys Lys Lys Arg Ser 
1               5                   10                  15      


Leu Asp Gln Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg 
            20                  25                  30          


His Asn Val Phe Leu Ile Val Asn His Leu Thr Asp Thr Phe Lys Glu 
        35                  40                  45              


Leu Asn Phe Lys Lys Leu Ala Asn Glu Glu Asp Ile Trp Lys Val Asp 
    50                  55                  60                  


Asn Ser Ser Asn Ile Leu Leu Asn Val Phe Asp Val Thr Gln Ser Lys 
65                  70                  75                  80  


Tyr Glu Asp Phe Arg Pro Arg Ile Phe His Tyr Leu Ile Lys Arg His 
                85                  90                  95      


His Leu Pro Leu Val Lys Ile Phe Asn Thr Glu Tyr Leu Gly Glu Asn 
            100                 105                 110         


Ile Leu Gln Asp Lys Ser Val Asp Tyr Glu Arg Leu His Gln Phe Leu 
        115                 120                 125             


Cys Leu Ser Phe Lys Glu Leu Thr Glu Phe Arg Asp Ser Tyr Ser His 
    130                 135                 140                 


Ser Ile Ala Ile Asp Glu Asn Gly Asn Lys Val Ser Arg Lys Thr Thr 
145                 150                 155                 160 


Leu Ala Asn Glu Leu Val Pro Glu Ile Asn Leu Leu Phe Lys Tyr Ala 
                165                 170                 175     


Pro Arg Tyr Ser Phe Leu Arg Asn Tyr Gln Thr Leu Asn Glu Gly Asp 
            180                 185                 190         


Phe Gln His Leu Asp Asn Tyr Gln Leu Phe Val Ala Asp Asn Gln Leu 
        195                 200                 205             


Thr His Gln Gly Arg Phe Phe Phe Ile Asn Leu Phe Leu Glu Arg Ser 
    210                 215                 220                 


Tyr Gly Ile Lys Phe Leu Lys Arg Phe Arg Gly Phe Lys Asn Glu Asn 
225                 230                 235                 240 


Thr Pro Pro Phe Lys Ala Thr Ile Gln Ser Phe Thr Thr Tyr Cys Leu 
                245                 250                 255     


Lys Val Pro Asp Ile Arg Leu Gly Asn Glu Asn Pro Lys Gln Ser Leu 
            260                 265                 270         


Leu Leu Asp Met Leu Thr Glu Leu Asn Lys Cys Pro Lys Glu Leu Phe 
        275                 280                 285             


Asn His Leu Thr Glu Asp Asp Lys Lys Glu Phe Glu Pro Asn Leu Asp 
    290                 295                 300                 


Glu Thr Ser Ser Thr Asn Val Leu Leu Asn Ser Thr Asn Tyr Glu Phe 
305                 310                 315                 320 


Phe Asp Ala Asp Glu Val Glu Glu Ala Ile Arg Glu Leu Thr Ala Gln 
                325                 330                 335     


Lys Arg His Asn Asp Arg Phe Pro Tyr Leu Ala Leu Arg Phe Leu Asp 
            340                 345                 350         


Glu Thr Met Ala Phe Ser Gln Leu Arg Phe Gln Leu Ser Leu Gly Lys 
        355                 360                 365             


Leu Ile Ile Lys Lys Pro Tyr Gln Lys Thr Ile Leu Gly Gln Pro Asn 
    370                 375                 380                 


Asp Arg Ile Ile Thr Lys Lys Leu Asn Val Phe Gly Arg Ile Ser Asp 
385                 390                 395                 400 


Phe Leu Asn Arg Glu Lys Glu Ile Ile Arg Ala Leu Ser Asn Asp Gln 
                405                 410                 415     


Asn Val Asp Phe Leu Glu Phe Glu Gln Phe Phe Pro His Tyr Asn Ile 
            420                 425                 430         


Asn Asn Asn Lys Ile Ala Phe Tyr Phe Leu Asn Asp Ser Asp Leu Thr 
        435                 440                 445             


Glu Glu Asn Leu Glu Ser Arg Leu Arg Asp Gln Glu Asn Arg Gln Pro 
    450                 455                 460                 


Thr Gly Phe Leu Ser Ile His Asp Leu Pro Lys Leu Val Leu Leu His 
465                 470                 475                 480 


Leu Leu Ala Pro Ser Glu Val Gln Lys Thr Leu Gln Arg Phe Ile Asn 
                485                 490                 495     


Asp Asn Asn Pro Ala Phe Phe Asp Leu Glu Leu Leu Ser Asn Ile Lys 
            500                 505                 510         


Ser Lys Val Val Tyr Glu Pro Ser Asn Phe Thr Lys Arg Ser Glu His 
        515                 520                 525             


Gln Tyr Arg Asp Ala Asp Lys Gln Glu Glu Glu Thr Glu Lys Gln Gln 
    530                 535                 540                 


Glu Tyr Gln Thr Leu Leu Asn Gln Arg Lys Arg Leu Leu Glu Gln His 
545                 550                 555                 560 


Leu Pro Lys Gly Val Lys Ile Asn Gln Ile Pro Glu Lys Val Leu Asp 
                565                 570                 575     


Phe Leu Met Asn Ile Ser Glu Pro Asn Glu Asn Lys Val Ile His Gln 
            580                 585                 590         


Lys Ile Lys Ser Ile Lys Asp Glu Ala Lys Thr Leu Leu Gln Arg Val 
        595                 600                 605             


Lys Asn Lys Gln Ala Ala Asn Glu Ile Pro Lys Leu Gly Glu Leu Ala 
    610                 615                 620                 


Thr Phe Leu Thr Arg Asp Ile Ile Asn Met Val Val Ser Glu Glu Leu 
625                 630                 635                 640 


Lys Lys Lys Ile Thr Ser Pro Tyr Ser Asn Lys Leu Gln Asn Lys Ile 
                645                 650                 655     


Ala Phe Phe Ser Leu Ser Lys Gln Glu Ile Ile Ser Leu Leu Asn Glu 
            660                 665                 670         


Leu Gln Leu Leu Asn Asn Glu Lys Gly His Val Phe Leu Ser Ser Arg 
        675                 680                 685             


Leu Ile Leu Glu Ser Asn Gly Leu Leu Ser Phe Tyr Lys Ser Tyr Leu 
    690                 695                 700                 


Glu Ala Lys Ile Ala Trp Ile Asp Lys Asn Leu Phe Leu Lys Gly Lys 
705                 710                 715                 720 


Lys Gly Gly Tyr Ile Ile Pro Glu Asn Lys Pro Val Pro Lys Thr Leu 
                725                 730                 735     


Gln Lys Ile Lys Gln Glu Val Ser Gln Phe Asp Phe Thr Gln Trp Leu 
            740                 745                 750         


Gln Asn Lys Ala Ala Met Pro Ile Asp Val Pro Asn Thr Ile Phe Asp 
        755                 760                 765             


Val Thr Leu Glu Asn Leu Leu Lys Thr Asn Leu Lys Lys Arg Gly Ile 
    770                 775                 780                 


Thr Val Lys Asp Thr Asp Lys Phe Ser Val Leu Leu Asn Lys Tyr Met 
785                 790                 795                 800 


Asp Lys Asp Thr Gln Pro Phe Tyr Gln Tyr Ser Arg Val Tyr Lys Lys 
                805                 810                 815     


Gln Asp Glu Glu Glu Ser Val Gln Val Val Gly Lys Trp Gly Lys Thr 
            820                 825                 830         


Leu Lys Lys Gln Tyr Gly Lys Phe Val Glu Glu Asn Glu Lys Val Ile 
        835                 840                 845             


Arg Phe Tyr Gln Ser Lys Asp Arg Val Ile Lys Leu Met Cys Asn Ala 
    850                 855                 860                 


Leu Leu Gln Ala Glu Asn Lys Thr Ala Leu Thr Asp Ser Phe Lys Leu 
865                 870                 875                 880 


Ala His Thr His Pro Asn Ser Lys Gln Asn Pro Leu Asp Thr Pro Met 
                885                 890                 895     


Arg Phe Glu Gln Lys Leu Phe Ser Asn Asp Lys Glu Thr Lys Val Leu 
            900                 905                 910         


Cys Thr Ile Tyr Ala Gln Asp Thr Glu Asn Gln Lys Asn Glu Ile Leu 
        915                 920                 925             


Ala Trp Asn Ser Leu Ser Glu Asp Asp Lys Lys Tyr Trp Leu Thr Leu 
    930                 935                 940                 


Thr Thr Lys Glu Ala Gln Lys Glu Trp Leu Ser Gly Lys Pro Glu Thr 
945                 950                 955                 960 


Glu Gln Glu Val Tyr His Gly Gln Lys Gly Tyr Gln Trp Thr Ile Lys 
                965                 970                 975     


Glu Val Gly Lys Phe Lys Arg Phe Val Lys Asp Arg Arg Ile Pro Ala 
            980                 985                 990         


Leu Val Asn Tyr Phe Glu Thr Thr  Lys Leu Pro Phe Ser  Leu Leu Glu 
        995                 1000                 1005             


Tyr Gln  Leu Lys Glu Tyr Asp  Arg Val Arg Glu Gln  Ile Phe Asp 
    1010                 1015                 1020             


Gly Val  Phe Lys Leu Glu Glu  Ala Ile Ser Gln Lys  Asp Trp Ala 
    1025                 1030                 1035             


Gly Ile  Trp Ala Leu Glu Gln  Glu Ala Arg Gly Arg  Lys Asn Tyr 
    1040                 1045                 1050             


His Gln  Val Gln Phe Asn Ile  Phe Glu Lys Tyr Leu  Gln Asn Thr 
    1055                 1060                 1065             


Leu Pro  Ser Tyr Asp Pro Ala  Ile Gly Val Ile Arg  Asn Lys Phe 
    1070                 1075                 1080             


Ser His  Asn Glu Phe Pro Asp  Leu Ile Gly Gln Gly  Ile Glu Lys 
    1085                 1090                 1095             


Ile Ser  Gln Ala Gln Ile Asp  Asp Tyr Glu Arg Asn  Lys His Leu 
    1100                 1105                 1110             


Lys Asp  Tyr Leu Ala His Ala  Gly Ile Ser Ile Ala  Gln Gln Ile 
    1115                 1120                 1125             


Leu Val  Ile Phe Glu Gln Lys  Ile Asn Asp Thr Leu  Thr Gln Leu 
    1130                 1135                 1140             


Thr Thr  His Gly 
    1145         


<210>  2573
<211>  1131
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2573

Met Glu Lys Thr Ile Glu Asn Gln Thr Gln Ser Lys Arg Thr Leu Asn 
1               5                   10                  15      


Asn Thr Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Asp Glu Glu Lys Ile Thr Thr Ser Phe Leu Val Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Arg Gln Ser Leu Val Tyr Ser Asn Leu Thr 
65                  70                  75                  80  


Arg Tyr Met His Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Asp 
                85                  90                  95      


Asp Glu Arg Asp Lys Ala Glu Asn Tyr Gly Lys Asp Phe Gly Asn Leu 
            100                 105                 110         


Thr Asp Thr Leu Lys Glu Ile Phe Lys Glu Leu Asn Glu Phe Arg Asn 
        115                 120                 125             


Asp Tyr Ser His Tyr Tyr Ser Thr Glu Lys Lys Asp Lys Arg Lys Thr 
    130                 135                 140                 


Ile Val Ser Asp Lys Leu Lys Asn Phe Leu Asn Ile Asn Tyr Thr Arg 
145                 150                 155                 160 


Ala Ile Lys Tyr Thr Lys Ser Arg Phe Ile Asn Val Phe Ser Asp Asn 
                165                 170                 175     


Asn Phe Cys Leu Ala Glu Glu Ala Lys His Val Glu Asn Asp Asn Thr 
            180                 185                 190         


Ile Thr Gln Asp Gly Ile Val Phe Phe Thr Ser Met Phe Leu Asp Arg 
        195                 200                 205             


Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile Ile Gly Leu Lys Gly Thr 
    210                 215                 220                 


Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Thr Leu Met Ala Phe Cys 
225                 230                 235                 240 


Val Asn Leu Pro His Asp Lys Phe Val Ser Glu Asn Ser Glu Gln Gln 
                245                 250                 255     


Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu 
            260                 265                 270         


Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln His Phe Leu Pro Lys Leu 
        275                 280                 285             


Asp Asp Glu Gln Ile Asp Asn Val Leu Glu Asn Ser Val Pro Tyr Thr 
    290                 295                 300                 


Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn Ile Thr Lys Lys Val Arg 
305                 310                 315                 320 


Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu Lys Phe Ile Asp Gln Lys 
                325                 330                 335     


Lys Leu Phe Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val 
            340                 345                 350         


Leu Asp Glu Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Lys Arg Thr 
        355                 360                 365             


Val Thr Glu Asn Thr Lys Ala Phe Gly Met Leu Gln Asp Leu Asn Asp 
    370                 375                 380                 


Glu Glu Asn Val Leu Asn Lys Ile Asn Thr Gly Glu Ser Lys Ala Lys 
385                 390                 395                 400 


Phe Asp Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Thr Lys Asn 
            420                 425                 430         


Thr Asp Asn Lys Ile Lys Ser Asn Leu Leu Gln Pro Leu Pro Glu Ala 
        435                 440                 445             


Phe Leu Ser Ile Asn Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
    450                 455                 460                 


Glu Gln Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn 
465                 470                 475                 480 


Asn Ser Lys Ile Leu Asn Lys Glu Phe Ile Lys Ala Ile Lys Leu Lys 
                485                 490                 495     


Leu Asn Asp Leu Asp Val Phe Tyr Lys Arg Ser Gln Gly Arg Lys Gln 
            500                 505                 510         


Lys His Ala Tyr Leu Thr Lys Asp Lys Lys Tyr Asp Asn Glu Lys Ile 
        515                 520                 525             


Asn Glu Leu Lys Asn Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu 
    530                 535                 540                 


Tyr Asn Leu Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp 
545                 550                 555                 560 


Leu Asn Ile Ala Asp Val Gln Ala Lys Asn Ala Ile Ser Asp Arg Ile 
                565                 570                 575     


Lys Leu Met Lys Arg Asp Cys Ile Asn Arg Leu Lys Ser Met Lys Lys 
            580                 585                 590         


Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp 
        595                 600                 605             


Ile Val Asp Met Ile Ile Asp Glu Glu Lys Lys Lys Lys Ile Thr Ser 
    610                 615                 620                 


Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Lys 
625                 630                 635                 640 


Glu Lys Lys Glu Leu Phe Ile Leu Ile Cys Asn Asn Glu Leu Lys Leu 
                645                 650                 655     


Asn Asp Asp Asp Gly His Pro Phe Phe Lys Asn Ile Asn Phe Ser Asn 
            660                 665                 670         


Tyr Lys Tyr Thr Ser Glu Ile Tyr Gln Lys Tyr Leu Glu Glu Lys Gly 
        675                 680                 685             


His Lys Met Val Lys Glu Tyr Asn Pro Arg Lys Glu Asn Tyr Val Glu 
    690                 695                 700                 


Lys Asp Lys Ser Trp Leu Glu Ile Asn Phe Tyr Lys Lys Glu Trp Asn 
705                 710                 715                 720 


Glu Asn Ala Lys Lys Asp Leu Thr Val Val Lys Leu Pro Asp Asp Lys 
                725                 730                 735     


Ser Lys Ile Pro Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser 
            740                 745                 750         


Phe Glu Asn Trp Phe Lys Tyr Val Thr Asn Gly Lys Glu Thr Thr Asp 
        755                 760                 765             


Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp Glu Thr Leu 
    770                 775                 780                 


Lys Glu Leu Leu Lys Lys Glu Leu Ser Lys Asn Asn Ile Glu Phe Lys 
785                 790                 795                 800 


Glu Glu Asp Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Asp Lys Cys 
                805                 810                 815     


Arg Asn Asp Lys Thr Gln Lys Phe Tyr Ser Ala Glu Arg Glu Tyr Thr 
            820                 825                 830         


Phe Glu Glu Glu Lys Leu Asn Phe His Ile Asn Thr Lys Ser Lys Phe 
        835                 840                 845             


Glu Glu Tyr Ile Asn Pro Glu Phe Ala Glu Lys Val Phe Arg Leu Lys 
    850                 855                 860                 


Asn Gln Asn Arg Glu Lys Asp Asn Ile Ser Gly Arg Arg Leu Pro Pro 
865                 870                 875                 880 


Leu Lys Met Lys Glu Val Thr Lys Asn Met Val Lys Arg Ile Gly Asn 
                885                 890                 895     


Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Leu Met Leu 
            900                 905                 910         


Leu Met Phe Glu Lys Leu Val Asp Asn Asn Leu Lys Leu Lys Leu Glu 
        915                 920                 925             


Asn Val Asp Lys Leu Leu Asn Glu Ser Ile Glu Ile Asn Gln Ser Ile 
    930                 935                 940                 


Ser Gly Lys Leu Ser Phe Asp Asp Ser Gly Asp Asn Glu Asn Lys Lys 
945                 950                 955                 960 


Asp Arg Ala Ile Ile Cys Arg Asn Ile Thr Glu Thr Arg Lys Arg Lys 
                965                 970                 975     


Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Glu Glu Glu  Asn Ile Pro Ile Glu  Lys Ile Lys 
        995                 1000                 1005             


Ile Glu  Leu Asp Thr Tyr Ser  Lys Ala Lys Asp Val  Val Phe Asp 
    1010                 1015                 1020             


Leu Ile  Phe Asp Leu Glu Arg  Ala Ile Ile Asn Lys  Asp Glu Asn 
    1025                 1030                 1035             


Arg Ile  Lys Glu Leu Asn Lys  Asp Lys Asn Gly Val  Ile Gln Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Phe Trp Leu  Leu Glu Lys 
    1055                 1060                 1065             


Asn Leu  Ile Thr Glu Gln Glu  Phe Thr Phe Met Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Thr  Phe Ser His Asn Gln  Phe Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Leu Phe  Ile Lys Asn Trp Asn  Glu Asn Glu Phe Ala  Lys Gln Ile 
    1100                 1105                 1110             


Leu Asn  Val Tyr Asn Gln Lys  Asn Asn Asn Leu Ile  Lys Ser Ile 
    1115                 1120                 1125             


Lys Asp  Ile 
    1130     


<210>  2574
<211>  1180
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2574

Met Lys Lys Asn Ile Asn Pro Phe Asn Leu Phe Phe Leu Glu Lys Gly 
1               5                   10                  15      


Tyr Ile Gly Ser Ile Ala Gln Lys Ala Glu Asn Asn Phe Ser Thr Asn 
            20                  25                  30          


Cys Lys Ala Leu Asn Gly Ser Gln Ile Ser Asp Lys Glu Asn Lys Ala 
        35                  40                  45              


Thr Ser Arg Ile Tyr Tyr Phe Ala Val Gly His Ala Phe Lys Asn Ile 
    50                  55                  60                  


Asp Thr Lys Ala Ile Phe Ala Tyr Lys Tyr Asp Asp Asp Lys Lys Asn 
65                  70                  75                  80  


Leu Arg Ala Thr Gln Tyr Val His Ile Gln Arg Asn Val Phe Asp Gln 
                85                  90                  95      


Gly Leu Arg Asp Phe Ile Gly Glu Lys Val His Ala Ile Arg Asn Met 
            100                 105                 110         


Cys Ser His Tyr Val His Leu Phe Asn Asp Ile Lys Leu Glu Asp Glu 
        115                 120                 125             


Asp Ser Asp Lys Ala Asn Ile Ile Gln Asp Gln Phe Ile Pro Phe Val 
    130                 135                 140                 


Lys Glu Ala Phe Lys Leu Ala Val Val Gln Ala Tyr Pro Gly Glu Ser 
145                 150                 155                 160 


Asp Met Thr Ile Asp Lys Val Asp Asp Ala Lys Ile Ile Arg Phe Leu 
                165                 170                 175     


Tyr Asp Asn Phe Ile Ser Lys Gly Glu Tyr Asp Asp Leu Glu Glu Lys 
            180                 185                 190         


Lys Gln Phe Phe Lys Leu Ser Ser Asp Lys Ala Leu Glu Lys Val Leu 
        195                 200                 205             


Phe Ile Asp Leu Asp Glu Asp Gln Ser Ile Cys Ile Gly Pro Gly Tyr 
    210                 215                 220                 


Glu Val Phe Thr Ala Thr Lys Gly Arg Tyr Leu Ser Phe Tyr Ala Ser 
225                 230                 235                 240 


Leu Phe Leu Leu Ser Met Phe Leu Tyr Arg Asn Glu Ala Glu Ile Leu 
                245                 250                 255     


Ile Ser Arg Ile Lys Gly Phe Lys Asp Lys Arg Asp Ile Gly Asn Ile 
            260                 265                 270         


Ala Lys Arg Ser Val Phe Thr Phe Phe Ser Lys Lys Val Ser Ser Arg 
        275                 280                 285             


Asp Val Asp Asn Glu Glu Met Pro Leu Val Lys Phe Arg Asp Ile Met 
    290                 295                 300                 


Gln Tyr Leu Asn His Tyr Pro Thr Ala Trp Asn Asp Gln Leu Ser Asp 
305                 310                 315                 320 


Tyr Ser Ser Ser Glu Ser Ser Lys Asn Leu Cys Asn Lys Ile Val Glu 
                325                 330                 335     


Met Asp Ile Lys Arg Leu Phe His Glu Met Phe Glu Thr Glu Asn Glu 
            340                 345                 350         


Glu Ser Leu Arg Phe Leu Thr Tyr Val Lys Leu Thr Gln Tyr Glu Ala 
        355                 360                 365             


Leu Tyr Pro Lys Lys Tyr Val Arg Ala Glu Phe Leu Lys Ala Asp Phe 
    370                 375                 380                 


Thr Ser Arg Glu Thr Glu His Phe Asp Ile Ile Ile Lys Glu Ser Lys 
385                 390                 395                 400 


Glu Leu Lys Gly Cys Arg Lys Lys Leu Gln Asp Leu Leu His Ala Asp 
                405                 410                 415     


Ser Leu Gly Asn Glu Lys Glu Lys Glu Ile Ala Glu Cys Thr Glu Lys 
            420                 425                 430         


Ile Gln Glu Leu Glu Gly Ala Glu Thr Asn Pro Asp Leu Asp Ala Val 
        435                 440                 445             


Arg Lys Gln Ile Asp Asp His Leu Phe Ile Thr Ser Tyr Gly Arg Asn 
    450                 455                 460                 


Gln Asp Arg Phe Met Asp Phe Ala Ala Arg Phe Leu Ala Glu Val Glu 
465                 470                 475                 480 


Tyr Phe Gly Lys Asp Ala Phe Phe Lys Val Tyr Arg Phe Glu Thr Ile 
                485                 490                 495     


Glu Glu Gln Ser Lys Tyr Leu Glu Lys Val Lys Asn Gln Leu Pro Lys 
            500                 505                 510         


Glu Gln Tyr Asp Lys Leu Lys Met His Arg Gly Arg Leu Ala Thr Tyr 
        515                 520                 525             


Met Asn His Asn Gln Ile Ile Asn Tyr Tyr Ser Ser Phe Asp Ile Pro 
    530                 535                 540                 


Phe Val Ile Glu Asn Asn Ser Ile Gln Val Phe Met Pro Ser Ser Lys 
545                 550                 555                 560 


Ile Ile Glu Asp Met Asp Asp Gln Met Leu Lys Lys Ile Phe Lys Gly 
                565                 570                 575     


Lys Gly Thr Phe Tyr Val Ile Gln Arg Pro Leu Ile Ile Tyr Leu Leu 
            580                 585                 590         


Glu Gln Phe Leu Tyr Glu Pro Ser Gly Arg Lys Lys Met Thr Phe Lys 
        595                 600                 605             


Ala Leu Ile Glu Asn Tyr Cys Gly Arg Arg Lys Lys Gly Leu Glu Lys 
    610                 615                 620                 


Tyr Glu Thr Leu Leu Leu Asn Asp Ser Asp Ser Lys Ala Ala Glu Leu 
625                 630                 635                 640 


Gln Asp Gln Arg Ser Glu Met Gly Lys Leu Leu Pro Lys Arg Leu Leu 
                645                 650                 655     


His His Tyr Leu Ser Asp Leu Pro Arg Glu Phe Met Pro Leu Gly Leu 
            660                 665                 670         


Thr Glu Leu Leu Glu Asp Ala Lys Gln Gln Glu Ala Arg Tyr Asp Lys 
        675                 680                 685             


Met Phe Asp Glu Ala Glu Arg Tyr Gly His Ser Asp Asp Leu Leu Lys 
    690                 695                 700                 


Lys Asn Lys Gly Lys Gln Phe Lys Leu Arg Phe Val Arg Lys Ala Trp 
705                 710                 715                 720 


Asn Leu Met Tyr Phe Thr Asp Ile Tyr Trp Val Gln Arg Met Glu Cys 
                725                 730                 735     


Gly Asp Lys His His Lys Gln Phe Asn Ile Thr Arg Asp Glu Phe Asn 
            740                 745                 750         


His Phe Ser Gln Trp Met Tyr Ala Phe Asp Glu Val Pro Glu Tyr Lys 
        755                 760                 765             


Glu Cys Leu Asn Arg Leu Phe Leu Ser Lys Arg Phe Phe Glu Val Lys 
    770                 775                 780                 


Glu Phe Ala Thr Leu Phe Glu Ser Gly Lys Ser Leu Glu Asp Phe Tyr 
785                 790                 795                 800 


Ser Lys Thr Lys Gly Leu Tyr Lys Arg Trp Leu Gly Asn Lys Gly Tyr 
                805                 810                 815     


Leu Asn Ser Asn Asn Lys Pro Lys Ile Glu Lys Asn Thr Trp Asn Asn 
            820                 825                 830         


Tyr Lys Lys Ile Leu Asp Gly Ser Thr Val Cys Ile Asn Leu Ser Leu 
        835                 840                 845             


Phe Ile Lys Ile Leu Glu Asp Lys Asn Leu Leu Glu Lys Asp Ala Asp 
    850                 855                 860                 


Asn His Ile Ile Tyr Lys Ala Gln Glu Asn Met Gln Tyr Leu Ile Ser 
865                 870                 875                 880 


Asp Tyr Tyr Met Asp Gln Thr Phe Asp Arg Val Tyr Lys Asp Arg Leu 
                885                 890                 895     


Gly Asp Asp Glu Ser His Ala Tyr Lys Lys Leu Tyr Asn Lys Leu Arg 
            900                 905                 910         


Thr Asn Arg Leu Glu Asp Ala Leu Leu Tyr Glu Met Ala Leu Tyr Tyr 
        915                 920                 925             


Met Ser Arg Val Asn Ile Gly Val Lys Glu Ala Arg Thr His Val Cys 
    930                 935                 940                 


Asp Leu Phe Asn Lys Glu Ile Asp Phe Ser Val Tyr Lys Asp Asp Asp 
945                 950                 955                 960 


Lys Glu Asn Tyr Leu Tyr Lys Val Gln Ile Pro Phe Tyr Lys Ile Asp 
                965                 970                 975     


Ala Phe Asp Arg Leu Ala Val Met Asn Lys Ser Tyr Asp Lys Phe Pro 
            980                 985                 990         


Pro Phe Thr His Gln Leu Tyr Gly  Tyr Leu Thr Glu Asp  Lys Tyr Gln 
        995                 1000                 1005             


Ser Val  Phe Leu Ser Ser Glu  Arg Asn Ala Ile Arg  Lys Arg Phe 
    1010                 1015                 1020             


Ile Glu  Thr Lys Ile Leu Thr  Phe Asp Asp Phe Cys  Lys Leu Leu 
    1025                 1030                 1035             


Ser Ser  Leu Arg Asp Asp Ser  Leu His Phe Ser Asn  Val His Met 
    1040                 1045                 1050             


Phe Ile  Glu Lys Tyr Thr Ile  Ile Ala Gly Gly Arg  Glu Ile Lys 
    1055                 1060                 1065             


Asn Gly  Glu Asp Met Ile Glu  Phe Asp Ala Ala Thr  Leu Phe Asp 
    1070                 1075                 1080             


Leu Gln  Asp Asp Arg Asp Met  Tyr Ala Lys Val Arg  Asn Ala Ala 
    1085                 1090                 1095             


Met His  Phe Asn Val Pro Glu  Ile Pro Tyr Lys Arg  Phe Leu Met 
    1100                 1105                 1110             


Lys Met  Gln Glu Gly Phe Ile  His Lys Trp Ile Ile  Pro Ser Asn 
    1115                 1120                 1125             


Pro Thr  Ala Trp Glu Ser Leu  Asn Lys Gly Met Gln  Glu Val Cys 
    1130                 1135                 1140             


Tyr Lys  Phe Met Asn Val Ile  Tyr Asn Arg Lys Lys  Gly Asp Glu 
    1145                 1150                 1155             


Ser Trp  Tyr Phe Asn Asn Val  Ile Lys Glu Leu Ile  Tyr Val Tyr 
    1160                 1165                 1170             


Asp Ser  Lys Ser Glu Lys Lys  
    1175                 1180 


<210>  2575
<211>  1174
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2575

Met Ala Phe Ser Ser Lys Gln Leu Glu Gln His Ile Leu Ala Ser Tyr 
1               5                   10                  15      


Tyr Asn Asp Ala Arg Leu Asn Ile Leu Ala Cys Leu Asn Asp Ile Arg 
            20                  25                  30          


Glu Lys Ser Gly Lys Arg Pro Ile Glu Asn Glu Asp Gln Ile Lys His 
        35                  40                  45              


Ala Phe Thr Asp Leu Ala Leu Ser Lys Ala Thr Pro Glu Arg Gln Thr 
    50                  55                  60                  


Glu Leu Ile Lys Gln Leu Arg His Arg Phe His Phe Leu Asp Leu Leu 
65                  70                  75                  80  


Thr Asp Ala Ser Pro Gln Val Ser Gln Lys Lys Lys Gln Asp Asn Ala 
                85                  90                  95      


Thr Pro Leu Pro His Tyr Tyr Glu Ser His Leu Thr Trp Met Leu Glu 
            100                 105                 110         


Leu Val Asn Gly Leu Arg Asn Thr Met Ala His Pro Val Asp Lys Glu 
        115                 120                 125             


Ile Thr Ile Ala Tyr Ala Ile His Lys Lys Leu Tyr Phe Ala Leu Ser 
    130                 135                 140                 


Lys Leu Tyr Asp Ser Ser Phe His Thr Ile Lys Thr Arg Phe Ser His 
145                 150                 155                 160 


Glu Thr Asn Ala Met Gln Pro Phe Gln Arg Cys Asp Ser Lys Gly Lys 
                165                 170                 175     


Pro Lys Ser Ala Lys Gln Phe Ala Phe Ala Leu Cys Thr Asp Pro Leu 
            180                 185                 190         


Asp Leu Ser Glu Ser Ser Asp Leu Pro Gln Ser Lys Val Leu His Asp 
        195                 200                 205             


Phe Gly His Ile Leu Phe Cys Ser Leu Phe Leu Glu Lys Ser Gln Ser 
    210                 215                 220                 


Ala Glu Leu Ile Asn Tyr Phe Trp Gln Thr Gln Gln Gly Ser Lys Trp 
225                 230                 235                 240 


Gly Asp Thr Val Gln Arg Thr Ile Ile Arg Glu Met Ile Ala Val Tyr 
                245                 250                 255     


Arg Val Arg Leu Pro Leu Gln Arg Leu Lys Ser Asp Asp Thr Ser Thr 
            260                 265                 270         


Ala Val Thr Leu Asp Thr Leu Ser Glu Leu Ser Arg Cys Pro Arg Ala 
        275                 280                 285             


Leu Leu Asp Ala Leu Ser Pro Asp Asp Gln Ala Arg Phe Arg Gly Asp 
    290                 295                 300                 


Val Gly Ser Asn Asp Ser Thr Asp Ala Ala Asp Ala Asp Thr Ser Glu 
305                 310                 315                 320 


Asn Thr Tyr Leu Phe Ala Arg Ser Arg Gln Glu Arg Phe Ile Pro Leu 
                325                 330                 335     


Met Met Arg Phe Phe Asp Phe Asn Pro Ala Asn Lys Leu Arg Phe Ala 
            340                 345                 350         


Val Asp Leu Gly Gln Phe Tyr Tyr Asn Val Arg Leu Lys Pro Ala Ser 
        355                 360                 365             


Gln Phe Thr Asp Glu Thr Ala Arg Val Arg Arg Leu Gly Gln Lys Ile 
    370                 375                 380                 


Leu Ala Tyr Gly Arg Leu Ser Asp Phe Asp Pro Asp Asp Lys Pro Ala 
385                 390                 395                 400 


Glu Trp Gln Gln Leu Glu Asn Asn Tyr Ser Val Ser Arg Asp Glu Glu 
                405                 410                 415     


Glu Gln Thr Leu Gln Asn Ala Ser Asp Thr Ile Gln Val Leu Lys Pro 
            420                 425                 430         


Tyr Ile Val Pro Thr Tyr Pro His Tyr His Tyr Phe Asp Asp Lys Ile 
        435                 440                 445             


Gly Phe Arg Leu Glu Ser Lys Pro Ala Thr Gly Tyr Pro Asp Leu Gln 
    450                 455                 460                 


Ala Leu Ala Val Asp Ser Ala Val Ile Leu Asn Ser Pro Ala Ser Arg 
465                 470                 475                 480 


Asp Met Met Pro Glu Phe Trp Val Ser Pro Ala Gln Leu Leu Ala Leu 
                485                 490                 495     


Val Phe Tyr Ser Gln Leu Gln Pro Ala Ser Pro Asn Gln Gln Arg Tyr 
            500                 505                 510         


Leu Ala Leu Asp Ile Leu Leu Thr Lys Tyr Arg Val Gly Met Lys Asn 
        515                 520                 525             


Leu Leu Asn Ala Leu Ala His Gly Asn Val Ser Leu Ser Gly Ala Pro 
    530                 535                 540                 


His Ser Ala Glu Arg Arg Glu Gln Ala Gln Gln Trp Val Asp Lys His 
545                 550                 555                 560 


Phe Asp His Asn Ala Gly Thr Arg Phe Ala Val Pro Leu Ser His Leu 
                565                 570                 575     


Pro Lys Val Val Ile Gln His Leu Leu Gly Ala Glu Asp Arg Gln Val 
            580                 585                 590         


Ala Val Ala Glu Val Val Ala Arg Ala Glu His Val Leu Ala Glu Thr 
        595                 600                 605             


Gln His Lys Gln Asp Gln Leu Lys Gln Leu Leu Gln His Ala Asp Lys 
    610                 615                 620                 


Lys Arg Gly Gln Lys Gly Phe Lys Ala Ile Lys Cys Gly His Ile Gly 
625                 630                 635                 640 


Asp Phe Leu Thr Asp Asp Leu Met Arg Phe Gln Pro Val Asp Ala Asp 
                645                 650                 655     


Lys Ser Asp Gly Gly Lys Ile Asn Ser Gln Gln Tyr Gln Ile Leu Gln 
            660                 665                 670         


Ala Ala Leu Ala Tyr Tyr Gly Ala His Val Asn Glu Pro Pro Lys Val 
        675                 680                 685             


Val Asp Leu Leu Arg Asp Ala Gly Leu Leu His Gly Lys Phe Ala His 
    690                 695                 700                 


Pro Phe Ile Ala Asp Leu Asn Leu Glu Ser Gln Pro Asn Gln Tyr Arg 
705                 710                 715                 720 


Gly Leu Ile Ser Phe Tyr Glu Ala Tyr Leu Lys Ala Arg Ala Arg Tyr 
                725                 730                 735     


Leu Lys Ala Phe Ile Lys Glu Gln Gln Gln Arg Arg Thr Val Thr Phe 
            740                 745                 750         


Val Pro Gln Trp Leu Arg Leu Arg Gln Pro Ser Ser Leu Gln Asn Trp 
        755                 760                 765             


Leu Asn Glu Gln Arg Asp Ala Asn Gly Asn Leu Thr Gln Pro Leu Pro 
    770                 775                 780                 


Leu Met Asp Asn Met Leu Tyr Pro Pro Ile Leu Ala Leu Val Gly Glu 
785                 790                 795                 800 


Ala Leu Asp Ile Asp Pro His Thr Leu Glu Gln Glu Gly Met Gln Arg 
                805                 810                 815     


Phe Met Arg Gly Asp Glu Glu Ile Ala Ile Pro Pro Ala Val Thr Trp 
            820                 825                 830         


Leu Ile Lys Arg Tyr Leu Gly Ala Arg Gly Asp Thr Ser Gln Leu Met 
        835                 840                 845             


Tyr Gln Tyr Pro Arg His His Gly Leu Phe Asp Thr Trp Leu Asp Lys 
    850                 855                 860                 


Arg Thr Pro Lys Gln Arg Phe Gln Glu Lys Pro Thr His Tyr Leu Pro 
865                 870                 875                 880 


Glu Ala Glu Arg Gln Ala Tyr Arg Asp Glu Ile Arg His Phe Val Gln 
                885                 890                 895     


Thr Asn Thr Ser Ala Lys Gln Ala Asp Val Glu Leu Arg Glu Lys Leu 
            900                 905                 910         


Gly Lys Leu Leu Lys Ala Tyr Gln Arg Asp Glu Gln Thr Ile Arg His 
        915                 920                 925             


Ser Val Ser Gln Asp Met Leu Leu Tyr Leu Ser Ala Arg Gln Tyr Leu 
    930                 935                 940                 


Glu Ser Leu His Leu Ser Asn Gly Gly Leu Ala Ala Lys Pro Ala Trp 
945                 950                 955                 960 


Ser Leu Gln Gly Ile Glu Lys Thr Leu Leu Arg Thr Glu Ile His Tyr 
                965                 970                 975     


Ala Leu Pro Val Pro Gly Thr Asp Lys Gln Val Phe His Pro Ala Cys 
            980                 985                 990         


Lys Ile Arg Asn Leu Gly Glu Leu  Gly Leu Leu Val Arg  Asp Arg Arg 
        995                 1000                 1005             


Leu Pro  Ser Leu Leu Arg Tyr  Tyr Ser Cys Asp Glu  Asn Ala Ile 
    1010                 1015                 1020             


His His  Ala Glu Ile Arg Ala  Glu Leu Asn Ser Tyr  Arg Arg Ala 
    1025                 1030                 1035             


Lys Val  Ala Val Met Ala Met  Val His Glu Leu Glu  Lys Thr Leu 
    1040                 1045                 1050             


Leu Lys  Val Leu Gly Asp Ile  Pro Glu Arg Thr Lys  Glu Gln Glu 
    1055                 1060                 1065             


Lys Gln  Ser Lys Asp Phe Gly  Lys Gly Arg His Gly  Asp Phe Leu 
    1070                 1075                 1080             


Phe Ala  Leu Tyr Gln Gln Gln  Arg Gln Arg Thr Gly  Asn Glu Ala 
    1085                 1090                 1095             


Glu Thr  Phe Ser Pro Ala Arg  Phe Lys Arg Thr Leu  Leu Ile Arg 
    1100                 1105                 1110             


Asn Ala  Phe Ser His Asn Gln  Tyr Pro Asp Ala Ala  Ala Phe Ile 
    1115                 1120                 1125             


Pro Ile  Ala Ala Gln Val Gln  Gly Glu Ala Val Pro  Ser Asn Pro 
    1130                 1135                 1140             


Ala Asn  His Arg Lys Val Ala  Glu Arg Leu Met Gln  Glu Met Glu 
    1145                 1150                 1155             


Asn Leu  Tyr Ser Pro Trp Met  Arg Tyr Leu Arg Gln  Tyr Lys Ala 
    1160                 1165                 1170             


Glu 
    


<210>  2576
<211>  1147
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2576

Met Glu Asn Gln Gly Gln Asn Lys Arg Thr Trp Gly Lys Asp Pro Gln 
1               5                   10                  15      


Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg Ser Asn Ile Tyr Asn Ile 
            20                  25                  30          


Asn Asn Gln Leu Ala Glu Thr Phe Val Ile Thr Pro Ile Asp Asp Glu 
        35                  40                  45              


Gly Lys Ile Ser Ser Ser Phe Leu Gly Asp Lys Ser Asn Gln Thr Phe 
    50                  55                  60                  


Lys Asn Lys Arg Asn His Ile Tyr Ser Lys Ile Ala Val His Met Pro 
65                  70                  75                  80  


Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Asp Asp Glu Lys Asp 
                85                  90                  95      


Lys Ser Glu Asn Asn Phe Gly Lys Asp Phe Asn Lys Leu Ser Asp Thr 
            100                 105                 110         


Leu Lys Val Val Phe Asp Glu Ile Asn Glu Phe Arg Asn Asp Tyr Ser 
        115                 120                 125             


His Tyr Tyr Ser Thr Glu Lys Lys Asp Glu Arg Lys Gln Lys Val Ser 
    130                 135                 140                 


Asp Glu Leu Ser Ile Phe Leu Lys Asn Asn Tyr Ile Arg Ala Lys Gln 
145                 150                 155                 160 


Tyr Thr Gln Ile Arg Phe Lys Asp Val Phe Ser Asp Glu Asp Phe Asn 
                165                 170                 175     


Ile Ala Ser Gln Ser Val Val Val Lys Asp Asp Asn Thr Ile Thr Gln 
            180                 185                 190         


Asp Gly Ile Ile Phe Leu Thr Ser Met Phe Leu Asp Arg Glu Asn Ala 
        195                 200                 205             


Phe Gln Phe Ile Asn Lys Ile Thr Gly Leu Lys Gly Thr Gln Thr Lys 
    210                 215                 220                 


Gly Phe Lys Ala Lys Arg Glu Val Leu Met Ala Phe Cys Val Lys Leu 
225                 230                 235                 240 


Pro His Asp Lys Phe Val Ser Glu Asn Thr Glu Gln Ala Phe Ser Leu 
                245                 250                 255     


Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu Tyr Asn Val 
            260                 265                 270         


Ile Thr Glu Glu Glu Ile Lys Lys Tyr Lys Phe Arg Pro Gln Leu Glu 
        275                 280                 285             


Ala Glu Gln Ile Glu Asn Ile Leu Asn Asn Ser Val Pro Asp Thr Ile 
    290                 295                 300                 


Asp Asp Tyr Lys Asn Tyr Ile Glu Ser Ile Thr Lys Arg Ile Arg Asn 
305                 310                 315                 320 


Lys Asn Arg Phe Ser Tyr Phe Ala Leu Lys Tyr Ile Asp Leu Lys Gly 
                325                 330                 335     


Leu Phe Lys Arg Leu Arg Phe Gln Ile Asp Leu Gly Lys Val Val Leu 
            340                 345                 350         


Asp Glu Tyr Ser Lys Leu Leu Asn Glu Lys Glu Glu Thr Arg Thr Val 
        355                 360                 365             


Val Glu Asn Ala Lys Ala Phe Gly Met Leu Gln Asp Phe Asn Asp Lys 
    370                 375                 380                 


Glu Arg Val Leu Asn Lys Ile Asn Thr Gly Glu Asn Lys Thr Cys Phe 
385                 390                 395                 400 


Glu Gln Phe Ala Pro His Tyr Asn Phe Asn Asp Lys Asn Asn Lys Ile 
                405                 410                 415     


Gly Ile Ser Ser Lys Lys Glu Ile Thr Thr Lys Tyr Leu Pro Lys Asn 
            420                 425                 430         


Thr Asn Lys Lys Val Lys Phe Tyr Leu Lys Gln Pro Leu Pro Glu Ala 
        435                 440                 445             


Phe Leu Ser Ile Arg Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
    450                 455                 460                 


Glu Ser Gly Lys Ala Glu Gln Leu Ile Asn Asp Phe Ile Gly Thr Asn 
465                 470                 475                 480 


Asn Leu Lys Ile Leu Asn Lys Gln Phe Ile Glu Ile Ile Lys Ser Lys 
                485                 490                 495     


Leu Ser Glu Phe Asp Ile Phe Phe Lys Arg Ser Gln Gly Arg Lys Asp 
            500                 505                 510         


Lys Ser Ala Tyr Lys Glu Gly Thr Leu Asn Tyr Leu Arg Glu Arg Lys 
        515                 520                 525             


Asp Lys Leu Asn Gln Ile Leu Ala Glu His Lys Leu Asn Val Lys Gln 
    530                 535                 540                 


Ile Pro Thr Arg Ile Leu Asp Tyr Trp Leu Asn Ile Lys Ala Val Gln 
545                 550                 555                 560 


Thr Lys Thr Thr Ile Ser Asp Arg Ile Lys Leu Met Lys Arg Asp Cys 
                565                 570                 575     


Met Asp Arg Leu Lys Ala Ile Glu Lys Lys Lys Thr Pro Lys Ile Gly 
            580                 585                 590         


Glu Met Ala Thr Phe Leu Ala Lys Asp Ile Val Asp Met Ile Ile Gly 
        595                 600                 605             


Glu Glu Lys Lys Lys Ile Ile Thr Thr Phe Tyr Tyr Asp Lys Met Gln 
    610                 615                 620                 


Glu Cys Leu Ala Leu Phe Ala Asp Lys Glu Lys Lys Glu Leu Phe Ile 
625                 630                 635                 640 


His Ile Cys Asn Asn Glu Leu Lys Leu Asn Asp Asp Asp Gly His Pro 
                645                 650                 655     


Phe Leu Lys Asn Ile Asn Ile Gln Asn Ile Arg Tyr Thr Thr Asp Leu 
            660                 665                 670         


Tyr Lys Arg Tyr Leu Glu Glu Lys Ser Asp Asn Arg Asn Glu Arg Asn 
        675                 680                 685             


Lys Met Asp Thr Ser Trp Leu Ala Arg Thr Phe Tyr Val Ile Glu Lys 
    690                 695                 700                 


Val Glu Val Phe Asp Lys Lys Lys Lys Arg Lys Val Ser Lys Pro Gln 
705                 710                 715                 720 


Thr Val Val Lys Leu Pro Gln Asp Lys Ser Lys Leu Pro Phe Thr Leu 
                725                 730                 735     


Arg Gln Leu Glu Lys Glu Lys Ser Ser Phe Asp Lys Trp Leu Glu His 
            740                 745                 750         


Val Thr Lys Gly Lys Glu Thr Thr Asp Lys Lys Lys Pro Ile Asp Leu 
        755                 760                 765             


Pro Thr Asn Leu Phe Asp Asp Glu Leu Lys Glu Leu Leu Lys Thr Glu 
    770                 775                 780                 


Leu Ser Lys Asn Asn Ile Lys Ile Lys Ser Glu Ala Asn Tyr Asn Glu 
785                 790                 795                 800 


Leu Phe Lys Ile Trp Trp Lys Glu Cys Arg Lys Asp Ser Thr Gln Ser 
                805                 810                 815     


Phe Tyr Glu Ala Glu Arg Glu Tyr Ser Phe Glu Glu Glu Lys Leu Asn 
            820                 825                 830         


Phe Lys Ile Asn Thr Gln Pro Lys Phe Val Glu Tyr Ile Gln Pro Asp 
        835                 840                 845             


Phe Thr Glu Lys Val Leu Asn Ile Lys His Ala Leu Lys Asn Val Lys 
    850                 855                 860                 


Arg Lys Phe Pro Pro Ile Glu Lys Ile Gln Val Ile Lys Thr Ile Thr 
865                 870                 875                 880 


Ser Lys Ile Gly Asn Thr Glu Lys Lys Ile Arg Met Leu Gln Glu Glu 
                885                 890                 895     


Asp Arg Leu Met Leu Leu Met Phe Glu Lys Met Ile Asp Ser Asp Leu 
            900                 905                 910         


Asn Leu Arg Leu Lys Glu Ala Asp Lys Leu Leu Ser Glu Ser Ile Leu 
        915                 920                 925             


Ile Lys Gln Asn Ile Thr Gly Glu Leu Ser Phe Asn Asp Tyr Gly Glu 
    930                 935                 940                 


Val Val Asn Lys Lys Asp Arg Lys Ile Ile Thr Lys Thr Ile Thr Glu 
945                 950                 955                 960 


Thr Arg Lys Arg Lys Glu Tyr Ser Val Leu Val Lys Tyr Ile Phe Asp 
                965                 970                 975     


Arg Arg Leu Pro Glu Leu Phe Glu Tyr Phe Lys Glu Asp Val Ile Thr 
            980                 985                 990         


Leu Glu Arg Ile Lys Leu Glu Leu  Asp Ala Tyr Ser Lys  Thr Lys Asp 
        995                 1000                 1005             


Ile Val  Phe Asp Ser Val Phe  Glu Leu Glu Lys Leu  Ile Ile Thr 
    1010                 1015                 1020             


Asn Asn  Leu Gln Asn Ile Leu  Asp Ile Asn His Lys  Leu Tyr Glu 
    1025                 1030                 1035             


Glu Glu  Lys Glu Leu Leu Ile  Asn Arg Leu Asn Glu  Asn Ser Lys 
    1040                 1045                 1050             


Asn Tyr  Glu Val Glu Lys Lys  Lys Ile Ile Asp Arg  Ile Asp Ser 
    1055                 1060                 1065             


Arg Lys  Asn Ile Pro His Lys  Ser Tyr Leu Ile Trp  Leu Phe Lys 
    1070                 1075                 1080             


Asn Glu  Ile Ile Asp Glu Lys  Glu Phe Thr Phe Met  Asn Ile Val 
    1085                 1090                 1095             


Arg Asn  Thr Phe Ser His Asn  Gln Phe Pro Gln Lys  Ser Thr Met 
    1100                 1105                 1110             


Glu Leu  Phe Ile Thr Lys Trp  Asn Asn Asn Lys Phe  Ala Cys Gln 
    1115                 1120                 1125             


Ile Leu  Glu Ile Tyr Lys Gln  Lys Thr Asp Asn Ile  Ile Lys Lys 
    1130                 1135                 1140             


Leu Lys  Asp Met 
    1145         


<210>  2577
<211>  1131
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2577

Met Glu Lys Thr Ile Glu Asn Gln Thr Gln Ser Lys Arg Thr Leu Asn 
1               5                   10                  15      


Asn Thr Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Asp Glu Glu Lys Ile Thr Thr Ser Phe Leu Val Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Arg Gln Ser Leu Val Tyr Ser Asn Leu Thr 
65                  70                  75                  80  


Arg Tyr Met His Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Asp 
                85                  90                  95      


Asp Glu Arg Asp Lys Ala Glu Asn Tyr Gly Lys Asp Phe Gly Asn Leu 
            100                 105                 110         


Thr Asp Thr Leu Lys Glu Ile Phe Lys Glu Leu Asn Glu Phe Arg Asn 
        115                 120                 125             


Asp Tyr Ser His Tyr Tyr Ser Thr Glu Lys Lys Asp Lys Arg Lys Thr 
    130                 135                 140                 


Ile Val Ser Asp Lys Leu Lys Asn Phe Leu Asn Ile Asn Tyr Thr Arg 
145                 150                 155                 160 


Ala Ile Lys Tyr Thr Lys Ser Arg Phe Ile Asn Val Phe Ser Asp Asn 
                165                 170                 175     


Asn Phe Cys Leu Ala Glu Glu Ala Lys His Val Glu Asn Asp Asn Thr 
            180                 185                 190         


Ile Thr Gln Asp Gly Ile Val Phe Phe Thr Ser Met Phe Leu Asp Arg 
        195                 200                 205             


Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile Ile Gly Leu Lys Gly Thr 
    210                 215                 220                 


Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Thr Leu Met Ala Phe Cys 
225                 230                 235                 240 


Val Asn Leu Pro His Asp Lys Phe Val Ser Glu Asn Ser Glu Gln Gln 
                245                 250                 255     


Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu 
            260                 265                 270         


Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln His Phe Leu Pro Lys Leu 
        275                 280                 285             


Asp Asp Glu Gln Ile Asp Asn Val Leu Glu Asn Ser Val Pro Tyr Thr 
    290                 295                 300                 


Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn Ile Thr Lys Lys Val Arg 
305                 310                 315                 320 


Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu Lys Phe Ile Asp Gln Lys 
                325                 330                 335     


Lys Leu Phe Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val 
            340                 345                 350         


Leu Asp Glu Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Lys Arg Thr 
        355                 360                 365             


Val Thr Glu Asn Thr Lys Ala Phe Gly Met Leu Gln Asp Leu Asn Asp 
    370                 375                 380                 


Glu Glu Asn Val Leu Asn Lys Ile Asn Thr Gly Glu Ser Lys Ala Lys 
385                 390                 395                 400 


Phe Asp Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Thr Lys Asn 
            420                 425                 430         


Thr Asp Asn Lys Ile Lys Ser Asn Leu Leu Gln Pro Leu Pro Glu Ala 
        435                 440                 445             


Phe Leu Ser Ile Asn Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
    450                 455                 460                 


Glu Gln Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn 
465                 470                 475                 480 


Asn Ser Lys Ile Leu Asn Lys Glu Phe Ile Lys Ala Ile Lys Leu Lys 
                485                 490                 495     


Leu Asn Asp Leu Asp Val Phe Tyr Lys Arg Ser Gln Gly Arg Lys Gln 
            500                 505                 510         


Lys His Ala Tyr Leu Thr Lys Asp Lys Lys Tyr Asp Asn Glu Lys Ile 
        515                 520                 525             


Asn Glu Leu Lys Asn Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu 
    530                 535                 540                 


Tyr Asn Leu Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp 
545                 550                 555                 560 


Leu Asn Ile Ala Asp Val Gln Ala Lys Asn Ala Ile Ser Asp Arg Ile 
                565                 570                 575     


Lys Leu Met Lys Arg Asp Cys Ile Asn Arg Leu Lys Ser Met Lys Lys 
            580                 585                 590         


Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp 
        595                 600                 605             


Ile Val Asp Met Ile Ile Asp Glu Glu Lys Lys Lys Lys Ile Thr Ser 
    610                 615                 620                 


Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Lys 
625                 630                 635                 640 


Glu Lys Lys Glu Leu Phe Ile Leu Ile Cys Asn Asn Glu Leu Lys Leu 
                645                 650                 655     


Asn Asp Asp Asp Gly His Pro Phe Phe Lys Asn Ile Asn Phe Ser Asn 
            660                 665                 670         


Tyr Lys Tyr Thr Ser Glu Ile Tyr Gln Lys Tyr Leu Glu Glu Lys Gly 
        675                 680                 685             


His Lys Met Val Lys Glu Tyr Asn Pro Arg Lys Glu Asn Tyr Val Glu 
    690                 695                 700                 


Lys Asp Lys Ser Trp Leu Glu Ile Asn Phe Tyr Lys Lys Glu Trp Asn 
705                 710                 715                 720 


Glu Asn Ala Lys Lys Asp Leu Thr Val Val Lys Leu Pro Asp Asp Lys 
                725                 730                 735     


Ser Lys Ile Pro Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser 
            740                 745                 750         


Phe Glu Asn Trp Phe Lys Tyr Val Thr Asn Gly Lys Glu Thr Thr Asp 
        755                 760                 765             


Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp Glu Thr Leu 
    770                 775                 780                 


Lys Glu Leu Phe Lys Lys Glu Leu Ser Lys Asn Asn Ile Glu Phe Lys 
785                 790                 795                 800 


Glu Glu Asp Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Asp Lys Cys 
                805                 810                 815     


Arg Asn Asp Lys Thr Gln Lys Phe Tyr Ser Ala Glu Arg Glu Tyr Thr 
            820                 825                 830         


Phe Glu Glu Glu Lys Leu Asn Phe His Ile Asn Thr Lys Ser Lys Phe 
        835                 840                 845             


Glu Glu Tyr Ile Asn Pro Glu Phe Ala Glu Lys Val Phe Arg Leu Lys 
    850                 855                 860                 


Asn Gln Asn Arg Glu Lys Asp Asn Ile Ser Gly Arg Arg Leu Pro Pro 
865                 870                 875                 880 


Leu Lys Met Lys Glu Val Thr Lys Asn Met Val Lys Arg Ile Gly Asn 
                885                 890                 895     


Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Leu Met Leu 
            900                 905                 910         


Leu Met Phe Glu Lys Leu Val Asp Asn Asn Leu Lys Leu Lys Leu Glu 
        915                 920                 925             


Asn Val Asp Lys Leu Leu Asn Glu Ser Ile Glu Ile Asn Gln Ser Ile 
    930                 935                 940                 


Ser Gly Lys Leu Ser Phe Asn Asp Ser Gly Asp Asn Glu Asn Lys Lys 
945                 950                 955                 960 


Asp Arg Ala Ile Ile Cys Arg Asn Ile Thr Glu Thr Arg Lys Arg Lys 
                965                 970                 975     


Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Glu Glu Glu  Asn Ile Pro Ile Glu  Lys Ile Lys 
        995                 1000                 1005             


Ile Glu  Leu Asp Thr Tyr Ser  Lys Ala Lys Asp Val  Val Phe Asp 
    1010                 1015                 1020             


Leu Ile  Phe Asp Leu Glu Arg  Ala Ile Ile Asn Lys  Asp Glu Asn 
    1025                 1030                 1035             


Arg Ile  Lys Glu Leu Asn Lys  Asp Lys Asn Gly Val  Ile Gln Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Phe Trp Leu  Leu Glu Lys 
    1055                 1060                 1065             


Asn Leu  Ile Thr Glu Gln Glu  Phe Thr Phe Met Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Thr  Phe Ser His Asn Gln  Phe Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Leu Phe  Ile Lys Asn Trp Asn  Glu Asn Glu Phe Ala  Lys Gln Ile 
    1100                 1105                 1110             


Leu Asn  Val Tyr Asn Gln Lys  Asn Asn Asn Leu Ile  Lys Ser Ile 
    1115                 1120                 1125             


Lys Asp  Ile 
    1130     


<210>  2578
<211>  1174
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (681)..(684)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (927)..(930)
<223>  Xaa can be any naturally occurring amino acid

<400>  2578

Met Glu Thr Asn Asn Thr Thr Ile Thr Arg Arg Tyr Gly Leu Lys Glu 
1               5                   10                  15      


Thr Pro Trp Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg His Asn Met 
            20                  25                  30          


Phe Leu Leu Val Asn His Val Thr Glu Lys Phe Ala Tyr Leu Asn Glu 
        35                  40                  45              


Lys Pro Leu Ala Ser Asp Glu Asp Ile Val Lys Asp Asp His Leu Leu 
    50                  55                  60                  


Val Lys Ile Phe Asp Pro Asp Lys Ser Val Tyr Glu Thr Glu Arg Met 
65                  70                  75                  80  


Lys Val Tyr Lys Tyr Leu Thr Ser Arg His Tyr Leu Pro Cys Ile Arg 
                85                  90                  95      


Ile Phe His Glu Gly Pro Gly Asp Val Thr Asp Thr Asn Pro Ile Val 
            100                 105                 110         


Asp Tyr Asp Gly Leu His Ala Phe Leu Arg Ser Ala Phe Asn Leu Leu 
        115                 120                 125             


Asn Ala Trp Arg Asn Ala Phe Thr His Tyr Leu Ala Ile Asp Asp Asn 
    130                 135                 140                 


Gly Asn Arg Leu Gln Glu Arg Ser Leu Val Ile Glu Gln Asp Met Lys 
145                 150                 155                 160 


Gly Tyr Leu Glu Arg Leu Phe Ala Arg Ala Pro Asp Phe Ser Leu Lys 
                165                 170                 175     


Arg Phe Glu Ala Thr His Glu Glu Lys Asp Phe Asp His Leu Ser Phe 
            180                 185                 190         


Tyr Arg Leu Phe Ser Glu Asp Asn Asp Leu Gln Leu Ser Glu Gln Gly 
        195                 200                 205             


Phe Tyr Phe Phe Ile Asn Leu Phe Leu Glu Arg Gly Tyr Ala Met Lys 
    210                 215                 220                 


Phe Leu Lys Lys Phe Arg Gly Phe Lys Asn Glu Thr Thr Pro Ser Phe 
225                 230                 235                 240 


Arg Ala Thr Leu Gln Ala Phe Thr Ala Tyr Thr Pro Arg Val Pro Asp 
                245                 250                 255     


Val Arg Leu Asp Thr Glu Asp Ser Arg Gln Thr Leu Leu Leu Glu Met 
            260                 265                 270         


Leu Asn Glu Leu Asn Arg Cys Pro Arg Glu Ile Tyr Lys Arg Leu Lys 
        275                 280                 285             


Glu Glu Asp Lys Gln Lys Leu Val Pro His Lys Gly Arg Ala Glu Glu 
    290                 295                 300                 


Ala Ser His Val Leu Ala Thr Thr Asp Tyr Arg Asp Ile Ser Asp Glu 
305                 310                 315                 320 


Asp Ile Asp Gly Leu Leu Ser Asp Ile Ser Pro Leu Tyr Arg Gly Gly 
                325                 330                 335     


Asp Arg Phe Pro Tyr Phe Ala Ala Arg Tyr Ile Asp Glu Phe Asp Leu 
            340                 345                 350         


Leu Pro Asn Ile Arg Phe Gln Ile Thr Leu Gly Lys Leu Gln Val Asp 
        355                 360                 365             


Ala Tyr Glu Lys Asn Ile Ala Gly Glu Ile Ile Glu Arg Arg Val Val 
    370                 375                 380                 


Arg Thr Val His Ala Tyr Gly Lys Leu Ser Asp Phe Thr Asn Arg Gln 
385                 390                 395                 400 


Asn Glu Val Leu Glu Ile Leu Gln Gln Gln Ser Val Ala Gly Glu Gly 
                405                 410                 415     


Ser Tyr Phe Gln Gln Tyr Ala Pro His Tyr Asn Met Glu Asn Asn Gln 
            420                 425                 430         


Leu Ser Phe Tyr Leu Phe Asn Glu Glu Asp Gln Asp Lys Val Lys Tyr 
        435                 440                 445             


Pro Ser Gln Leu Pro Gly Asn Thr Ser Gly Asn Ala Pro Thr Gly Phe 
    450                 455                 460                 


Leu Ser Leu Asn Asp Leu Pro Lys Leu Ala Leu Leu Gly Met Asp Lys 
465                 470                 475                 480 


Asn Lys Leu Ile Ala Glu Gln Val Ile Arg Asp Phe Ile Asn Ile Asn 
                485                 490                 495     


Arg Gly Leu Ile Leu Asn Phe Glu Ala Leu Glu Lys Leu Arg Ala Arg 
            500                 505                 510         


Leu Ser Leu Val Pro Lys Glu Phe Thr Arg Arg Val Val Asn Glu Lys 
        515                 520                 525             


Ser Ile Lys Gly Arg Asp Gly Met Pro Asp Tyr Leu Asn Lys Lys Lys 
    530                 535                 540                 


Glu Ala Arg Leu Leu Gln Ser Leu Arg Leu Ser Arg Glu Glu Leu Cys 
545                 550                 555                 560 


Arg Leu Glu Ser Asp Glu Leu Lys Arg Arg Ile Arg Asn Ser Lys Gln 
                565                 570                 575     


Leu Glu Tyr Ala Asn Gln Ile Arg Tyr Val His Phe Leu Glu Asn Arg 
            580                 585                 590         


Lys Lys Glu Leu Gln Glu His Leu Pro Glu Gly Leu Arg Val Asp Gln 
        595                 600                 605             


Leu Pro Glu Gln Val Val Arg His Leu Leu Asn Ile Asn Asp His Ser 
    610                 615                 620                 


Ser Glu Lys Ile Ile His His Lys Ile Lys Ala Ile Tyr Asp Asp Cys 
625                 630                 635                 640 


Arg Ile Arg Leu Arg Arg Ile Glu Thr Gln Glu Leu Lys Pro Glu Glu 
                645                 650                 655     


Glu Arg Asn Leu Lys Leu Gly Glu Leu Ala Thr Phe Leu Ser Arg Asp 
            660                 665                 670         


Ile Ile Asp Met Val Val Asp Gln Xaa Xaa Xaa Xaa Lys Gln Lys Ile 
        675                 680                 685             


Thr Ser Pro Tyr Tyr Asn Lys Leu Gln Thr Lys Ile Ser Tyr Phe Ser 
    690                 695                 700                 


Val Ser Arg Glu Glu Ile Ile Ala Leu Cys Asn Glu Leu Gln Leu Phe 
705                 710                 715                 720 


Gln Arg Glu Ser Gly His Val Phe Leu Ser Arg Glu Met Ile Met Gln 
                725                 730                 735     


Ser Arg Gly Ile Val Asp Phe Tyr Lys His Tyr Leu Thr Asp Lys Leu 
            740                 745                 750         


Glu Trp Ile Lys Asn Thr Leu Leu Ser Asp Asn Pro Arg Gly Gly Arg 
        755                 760                 765             


Tyr Thr Leu Pro Glu Lys Ala Ile Leu Pro Leu Ser Phe Phe Lys Ile 
    770                 775                 780                 


Arg Glu Lys Ala Gly Ser Gly Asp Phe Arg Gln Trp Leu Glu Arg Lys 
785                 790                 795                 800 


Lys Gln Met Pro Val Ser Leu Pro His Ser Leu Phe Asp Lys Glu Leu 
                805                 810                 815     


Glu Asp Arg Leu Ser Trp Arg Leu His Lys Glu Asn Ile Ser Phe Asn 
            820                 825                 830         


Glu Gly Asp Lys Phe Thr Ile Arg Leu Glu Lys Met Leu Glu Gly Asp 
        835                 840                 845             


Met Gln Pro Phe Tyr Asn Phe Pro Arg Ile Tyr Glu Val Asn Gly Glu 
    850                 855                 860                 


Pro Ala Glu Ile Asp Gly Ser Ser Leu Asp Gly Lys Thr Leu Lys Ser 
865                 870                 875                 880 


Arg Tyr Gly Asn Ser Val Glu Gln Ser Glu Lys Glu Ile Arg Phe Ile 
                885                 890                 895     


Arg Thr Arg Asp Arg Ile Leu Lys Leu Phe Cys Glu His Ile Leu Glu 
            900                 905                 910         


Thr Tyr Ser Asn Asp Lys Asn Thr Pro Phe His Pro Phe Gln Xaa Xaa 
        915                 920                 925             


Xaa Xaa Ile Tyr Pro Ser Ser Glu Thr Ser Pro Leu Asn Arg Pro Phe 
    930                 935                 940                 


Ser Phe Lys Gln Pro Ile Ile Arg Lys Gly Asn Glu Ala Tyr Ile Thr 
945                 950                 955                 960 


Val Ile Ala Arg Asp Thr Glu Gln Gln Leu Lys Glu Val Ser Glu Tyr 
                965                 970                 975     


Ser Leu Leu Thr Thr Asp Glu Glu Lys Asp Ala Phe Thr Gly Gln Lys 
            980                 985                 990         


Gly His Glu Trp Thr Ile Lys Asp  Phe Gly Arg Phe Lys  Arg Leu Ser 
        995                 1000                 1005             


Ala Asp  Arg Arg Ile Pro Ser  Leu Ser Asp Tyr Phe  Glu Phe Lys 
    1010                 1015                 1020             


Glu Val  Pro Phe Lys Leu Leu  Glu Tyr Gln Leu Lys  Glu Tyr Asp 
    1025                 1030                 1035             


Lys Tyr  Arg Glu Glu Ile Phe  Asp Ile Thr Phe Glu  Ile Glu Lys 
    1040                 1045                 1050             


His Ala  Cys Asp Val Ala Leu  Glu Asp Ile Thr Arg  Leu Glu Leu 
    1055                 1060                 1065             


Asn Lys  Arg Gln Ala Asp Gly  Ser Lys Asn Phe Asn  Asn Val Gln 
    1070                 1075                 1080             


Phe Gly  Ile Tyr Leu Gln Trp  Ile Gly Asp Asn Asp  Leu Leu Ser 
    1085                 1090                 1095             


Ser Asp  Glu Ile Asn Arg Leu  Arg Asn Ile Arg Asn  Lys Phe Ser 
    1100                 1105                 1110             


His Ser  Glu Phe Pro Thr Tyr  Trp Asp Ala Ile Pro  Lys Ile Thr 
    1115                 1120                 1125             


Lys Glu  Ala Val Ala Arg Phe  Glu Asp Asn Tyr Arg  Ile Thr Gly 
    1130                 1135                 1140             


Arg Ile  Glu Gln Leu Asp Ile  Ser Leu Ser Lys Leu  Ile Ala Glu 
    1145                 1150                 1155             


Asp Tyr  Arg Ser Ile Ala Asn  Lys Ile Leu Gln Arg  Ser Asn Ala 
    1160                 1165                 1170             


Ser 
    


<210>  2579
<211>  1160
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2579

Met Glu Gln Lys Gln Leu Glu Ser Arg Phe Asn Gln Ile Phe Asn Asn 
1               5                   10                  15      


Lys Gly His Thr Gly Pro Ile Ala Glu Lys Ala Val Lys Asn Phe Glu 
            20                  25                  30          


Thr Ile Arg Gln His Lys Val Ser Pro Arg Glu Arg Leu His Tyr Phe 
        35                  40                  45              


Ala Val Gly His Ala Leu Arg Asn Ile Asp Lys Asp Leu Lys Glu Ser 
    50                  55                  60                  


Ile Phe Glu Tyr Asn Leu Asp Glu Glu Gln Lys Lys Gln Lys Pro Thr 
65                  70                  75                  80  


Gln Phe Thr Thr Leu Gln Ser Asp Phe Phe Arg Phe Glu Asn Ala Leu 
                85                  90                  95      


Leu Thr Leu Leu Lys Asp Ile Arg Asn Cys Asn Gly His Tyr Val His 
            100                 105                 110         


Thr Phe Asp Lys Leu Gln Leu Asp Glu Ile Leu Lys Leu Gln Glu Lys 
        115                 120                 125             


Asn Lys Glu His Gly Ile Leu Asn Lys Asp Ala Gly Cys Gln Ile Ile 
    130                 135                 140                 


Glu Phe Leu Lys Glu Ala Phe Glu Phe Ser Ile Leu Ile Gln Phe Leu 
145                 150                 155                 160 


Lys Glu Lys Pro Lys Glu Tyr Glu Lys Phe Lys Lys Arg Lys Asn Glu 
                165                 170                 175     


Asn Lys Asn Gln Ser Leu Arg Asn Leu Ile Gly Gly Tyr Glu Lys Lys 
            180                 185                 190         


Leu Val Lys Tyr Leu Cys Asp Lys Phe Phe Pro Asn Glu Glu Lys Gln 
        195                 200                 205             


Lys Glu Ile Arg Asp Lys Phe Ile Glu His Asn Leu Glu Glu Ala Ile 
    210                 215                 220                 


Glu Asp Leu Leu Phe Ile Pro Val Asp Glu Asp Ile Glu Trp Lys Leu 
225                 230                 235                 240 


Gly Glu Glu His Val Val Phe Val Ile Lys Lys Gly Lys Tyr Leu Ser 
                245                 250                 255     


Phe Tyr Ala Gln Leu Phe Leu Leu Ser Met Phe Leu Tyr Lys Gln Glu 
            260                 265                 270         


Ala Asn Gln Leu Ile Ser Lys Ile Arg Gly Phe Lys Arg Ser Glu Asp 
        275                 280                 285             


Glu Phe Gln Tyr Lys Arg Asn Ile Phe Thr Phe Phe Ser Lys Lys Val 
    290                 295                 300                 


Ser Ser Gln Asp Ile His Ser Glu Glu Lys His Leu Ile Tyr Phe Arg 
305                 310                 315                 320 


Asp Ile Ile Gln Tyr Leu Asn Arg Phe Pro Thr Ala Trp Asn Glu Tyr 
                325                 330                 335     


Leu Ser Pro Glu Arg Lys Asn Leu Pro Met Thr Lys Leu Leu Glu Lys 
            340                 345                 350         


Tyr Ile Leu Glu Glu Glu Ile Phe Arg Thr Phe Ser Thr Tyr Lys Asn 
        355                 360                 365             


Asp Cys Asn Arg Glu Leu Phe Leu Lys Tyr Thr Ile Lys Arg Leu Phe 
    370                 375                 380                 


Arg Lys Lys Ala Glu Leu Phe Asp Ala Glu Lys Ile Ser Ile Asp Asp 
385                 390                 395                 400 


Asn Leu Arg Lys Lys Phe Asn Tyr Glu Ile Asp Thr Ser Pro Glu Leu 
                405                 410                 415     


Lys Asn Ile His Glu Lys Leu Lys Gly Lys Leu Lys Pro Lys Asp Tyr 
            420                 425                 430         


Tyr Lys Asn Ile Lys Arg Lys Glu Glu Leu Glu Lys Glu Glu Asn Pro 
        435                 440                 445             


Glu Lys Leu Lys Leu Ile Lys Lys Val Thr Glu Glu Lys Leu Phe Thr 
    450                 455                 460                 


Ala Tyr Gly Arg Asn Arg Asp Arg Phe Met Asp Phe Ala Val Arg Tyr 
465                 470                 475                 480 


Leu Ala Glu Gln Asn Tyr Phe Gly Lys Asp Ala Glu Phe Lys Met Tyr 
                485                 490                 495     


Met Phe Glu Thr Thr Asn Glu Gln Glu Asn Tyr Leu Lys Glu Gln Lys 
            500                 505                 510         


Asn Thr Ala Asp Lys Lys Val Ile Asp Gln Asn Lys Tyr His Gln Gly 
        515                 520                 525             


Arg Leu Thr Cys Phe Lys Thr Tyr Gln Lys His Lys Asp Asp Tyr Gln 
    530                 535                 540                 


Asn Trp Asp Asp Pro Phe Val Phe Gln Asn Asn Ala Phe Gln Ile Val 
545                 550                 555                 560 


Leu Thr Phe Ser Asn Gly Glu Arg Lys Lys Phe Ser Ile Gln Arg Lys 
                565                 570                 575     


Leu Leu Ile Tyr Leu Leu Glu Asp Ala Leu Phe Asn His Ser Asp Ser 
            580                 585                 590         


Ile Glu Asp Lys Gly Lys Gln Leu Leu Glu Asp Tyr Phe Phe Asn Thr 
        595                 600                 605             


Leu Met Pro Asp Phe Glu Glu Ala Lys Gly Ser Tyr Lys Thr Ser Asp 
    610                 615                 620                 


Asp Val Asn Trp Lys His Arg Lys Leu Leu Pro Lys Arg Leu Ile Tyr 
625                 630                 635                 640 


Thr Val His Pro Pro Arg Arg Thr Asp Ser Glu Glu Gln Ile His Pro 
                645                 650                 655     


Phe Glu Lys Ile Leu Arg Glu Thr Gln Glu Gln Glu Arg Arg Tyr Arg 
            660                 665                 670         


Leu Leu Leu Gly Lys Ala Lys Asn Met Lys Leu Lys Glu Glu Phe Ile 
        675                 680                 685             


Lys Arg Asn Lys Gly Lys His Phe Lys Leu Arg Phe Ile Arg Lys Ala 
    690                 695                 700                 


Trp His Leu Met Tyr Phe Arg Glu Ile Tyr Glu Arg Arg Ala Lys Glu 
705                 710                 715                 720 


His Ser His His Lys Ser Phe His Ile Thr Arg Asp Glu Ile Asn Asp 
                725                 730                 735     


Phe Ser Arg Trp Met Tyr Ala Phe Asp Glu Val Pro Pro Tyr Lys Val 
            740                 745                 750         


Tyr Leu Arg Asn Met Leu Gln Arg Lys Lys Phe Met Glu Asn Glu Glu 
        755                 760                 765             


Phe Ala Glu Leu Phe Glu Lys Gly Lys Ser Leu Asp Glu Phe Tyr His 
    770                 775                 780                 


Leu Thr Lys Gln Glu Phe Ser Lys Arg Ile Lys Asn Asn Leu Phe Gln 
785                 790                 795                 800 


Leu Lys Val Asp Ser Glu Arg Gln Tyr Ala Glu Val Leu Ser Lys Lys 
                805                 810                 815     


Leu Val Tyr Ile Asn Leu Ser His Phe Ile Lys Tyr Leu Asn Ala Lys 
            820                 825                 830         


Gly Lys Leu Thr Val Glu Asn Gly Ile Ile Gln Tyr Lys Ala Ser Thr 
        835                 840                 845             


Asn Lys Lys Tyr Leu Ile Asp Glu Tyr Tyr Tyr Thr Glu Val Leu Pro 
    850                 855                 860                 


Arg Glu Glu Tyr Lys Val His Lys His Leu Phe Asn Lys Leu Arg Ala 
865                 870                 875                 880 


Ala Lys Leu Glu Asp Ala Leu Leu Tyr Glu Leu Ala Met Lys Tyr Leu 
                885                 890                 895     


Lys Glu Asp Glu Glu Ile Val Glu Lys Ala Lys Ser Lys Val Ser Asp 
            900                 905                 910         


Ile Gln Ser Ser Glu Ile Ser Phe Asp Ile Lys Asp Tyr Tyr Gly Asn 
        915                 920                 925             


His Leu Tyr Thr Leu Ile Val Pro Phe Asn Lys Leu Glu Thr Leu Ser 
    930                 935                 940                 


Ile Leu Ile Arg Tyr Lys Thr Gly Gln Glu Asn Glu Leu Lys Asn Lys 
945                 950                 955                 960 


Lys Thr Ser Phe Leu Gly Asn Ile Tyr His Leu Leu Ala Phe Leu Asp 
                965                 970                 975     


Lys Asn Tyr Lys Gln Leu Ser Lys Tyr Lys Asp Asp Gly Gly Phe Lys 
            980                 985                 990         


Lys Ile Val Lys Asn Phe Lys Asn  Lys Lys Arg Leu Ser  Phe Val Glu 
        995                 1000                 1005             


Leu Asn  Thr Ile Asn Gly Tyr  Ile Ile Ser Gly Ala  Val Lys Phe 
    1010                 1015                 1020             


Ser Lys  Val His Met Glu Leu  Glu Arg Tyr Phe Ile  Asn Lys His 
    1025                 1030                 1035             


Lys Ile  Lys Ala Asn His Ile  Tyr Ile Asp Leu Glu  Asp Ile Lys 
    1040                 1045                 1050             


Asp Asp  Ser Asn Lys Gln Val  Phe Gly Asn Tyr Tyr  Asp Ser Lys 
    1055                 1060                 1065             


Leu Arg  Ile Arg Asn Lys Ala  Phe His Phe Gly Val  Pro Thr Asn 
    1070                 1075                 1080             


Phe Phe  Phe Asn Ile Glu Ile  Glu Lys Ile Glu Lys  Lys Phe Ile 
    1085                 1090                 1095             


Leu Glu  Glu Val Lys Leu Gln  Asn Val Ser Ser Phe  Asp Lys Leu 
    1100                 1105                 1110             


Asn Gln  Asn Ala Lys Ser Val  Cys Arg Val Phe Met  Glu Val Leu 
    1115                 1120                 1125             


His Ser  Asp Leu Tyr Arg Arg  Asp Lys Asn Lys Ser  Lys Glu Glu 
    1130                 1135                 1140             


Leu Arg  Arg Glu Phe Glu Glu  Lys Tyr Phe Asn Glu  Ile Ile Thr 
    1145                 1150                 1155             


Thr Val  
    1160 


<210>  2580
<211>  1166
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2580

Met Glu Thr Arg Pro Met Glu Asn Lys Asn Ala Tyr Asn His Leu Thr 
1               5                   10                  15      


Thr Asp Asp Lys His Tyr Phe Gly Gly Phe Leu Asn Leu Ala Gln Asn 
            20                  25                  30          


Asn Ile Asp Arg Ile Phe Gln Glu Phe Cys Asp Arg Leu Asn Leu Lys 
        35                  40                  45              


Cys Glu Pro Gly Lys His Lys Asp Ile Ile Asn Gly Phe Phe Lys Asp 
    50                  55                  60                  


Lys Ala Ser Tyr Thr Asp Trp Glu Tyr Gly Ile Leu Ile Leu Lys Glu 
65                  70                  75                  80  


Tyr Leu Pro Val Ile Ser Ile Ile Asp Ile Pro Leu Ser Asn Lys Arg 
                85                  90                  95      


Ile Glu Val Leu Ala Glu Lys Lys Glu Tyr Lys Gly Lys Ser Lys Glu 
            100                 105                 110         


Glu Ile Lys Arg Ala Tyr Phe Arg Arg Thr Phe Cys Met Leu Leu Thr 
        115                 120                 125             


Ala Val Asn Asp Leu Arg Asn Tyr Tyr Thr His Tyr Tyr His Ala Pro 
    130                 135                 140                 


Ile Ala Leu Asp Glu Gly Leu Phe Phe Phe Leu Asp Glu Ala Leu Leu 
145                 150                 155                 160 


His Thr Val Lys Asp Val Arg Asn Asn Lys Met Lys Ala Asp Lys Thr 
                165                 170                 175     


Arg Gln Leu Leu Lys Lys Ser Leu Thr Ala Glu Leu Glu Lys Leu Cys 
            180                 185                 190         


Ala Leu Arg Lys Glu Glu Leu Lys Glu Lys Lys Lys Leu Gln Pro Lys 
        195                 200                 205             


Val Asn Leu Asn Asp Ser Ala Gly Ile Glu Asn Ala Val Leu Asn Arg 
    210                 215                 220                 


Ala Phe Ser Pro Leu Leu Tyr Lys Asp Lys Glu Ser Asp Cys Glu Ala 
225                 230                 235                 240 


Leu Ser Lys Tyr Phe Ser Ala Arg Leu Pro Glu Glu Met Gln His Glu 
                245                 250                 255     


Ala Gly Val Pro Ile Ser Ile Ser Gly Leu Ile Phe Leu Leu Ser Met 
            260                 265                 270         


Phe Leu Arg Arg Lys Glu Val Glu Gln Phe Met Ser Asn Ile Glu Arg 
        275                 280                 285             


Phe Lys Ile Arg Gln Ile Glu Ile Glu Glu Val Ser Glu Lys Gln Asn 
    290                 295                 300                 


Thr Leu Arg Ile Ile Ala Leu Arg Trp Val Phe Ser Thr Met Ala Phe 
305                 310                 315                 320 


Lys Gly Val Lys Arg Arg Ile Thr Ser Thr Phe Glu Lys Glu Thr Leu 
                325                 330                 335     


Met Met Gln Met Ile Asp Glu Leu Asn Lys Val Pro Asp Glu Val Tyr 
            340                 345                 350         


Gln Thr Leu Ser Asn Lys Asn Lys Asp Gln Phe Ile Glu Asp Ile Asn 
        355                 360                 365             


Glu Tyr Val Ser Glu Thr Asn Lys Glu Asn Glu Asp Pro Leu Tyr Val 
    370                 375                 380                 


Ile His Pro Val Ile Arg Lys Arg Tyr Glu Asn Lys Phe Asn Tyr Phe 
385                 390                 395                 400 


Ala Ile Arg Phe Leu Asp Glu Tyr Ala Gln Phe Pro Thr Leu Arg Phe 
                405                 410                 415     


Gln Val Phe Ala Gly Gln Tyr Leu His Asp Lys Arg Glu Lys Lys Ile 
            420                 425                 430         


Ala Gly Ile Lys Leu Leu Ser Glu Arg Leu Val Lys Glu Lys Ile Asn 
        435                 440                 445             


Val Phe Gly Lys Leu Ser Asp Val Val Gln Lys Lys Asn Asp Tyr Phe 
    450                 455                 460                 


Lys Thr His Gln Thr Leu Lys Asp Lys Cys Trp Glu Leu Phe Pro Asn 
465                 470                 475                 480 


Pro Ser Tyr Asn Phe Ala Thr Asn Asn Ile Tyr Val Tyr Ile Asp Leu 
                485                 490                 495     


Phe Arg His Gly Glu Arg Ala Lys Glu Val Gln Val His Ile Asn Arg 
            500                 505                 510         


Leu Ser Lys Asn Leu Asn Arg Asp Arg Thr Gln Arg Ile Ser Lys Glu 
        515                 520                 525             


Gln Ile Ile Lys Ile Val Phe Asp Gly Leu Glu Val Asn Arg His Pro 
    530                 535                 540                 


Thr Leu Gln Leu Ser Met His Glu Leu Met Ser Ile Leu Tyr Glu Phe 
545                 550                 555                 560 


Leu Val Lys Lys Arg Thr Gly Glu Glu Ile Glu Lys Arg Ile Val Glu 
                565                 570                 575     


Lys Ile Val Glu Lys Tyr Asp Leu Leu Met Gly Tyr Asp Ser Lys Gln 
            580                 585                 590         


Thr Asp Val Ser Lys Lys Glu Leu Pro Lys Lys Leu Leu Lys Ser Ile 
        595                 600                 605             


Pro Gly Asn Asp Gln Ile Asp Tyr Ala Lys Leu Gln Arg Ala Ile Lys 
    610                 615                 620                 


Gln Glu Ile Lys Asn Gly Glu Glu Lys Leu Lys Leu Ile Arg Asp Asn 
625                 630                 635                 640 


Arg Lys Glu Ala Lys Ala Tyr Glu Gly Leu Arg Glu Lys Lys Gly Lys 
                645                 650                 655     


Arg Lys Phe Val Phe Tyr Ser Lys Glu Lys Gly Arg Glu Ala Thr Trp 
            660                 665                 670         


Ile Ala Asn Asp Leu Lys Lys Phe Met Pro Val Phe Thr Arg Thr Asn 
        675                 680                 685             


Trp Lys Gly Ile Gln His Ser Glu Leu Gln Lys Leu Ile Ala Tyr Tyr 
    690                 695                 700                 


Asp Thr Glu Tyr Asn Gln Val Lys Thr Leu Leu Gly Ser Val Trp Asp 
705                 710                 715                 720 


Ile His Thr Asp Ala Asp Lys Gly Lys Ile Leu Phe Glu Ala Phe Asn 
                725                 730                 735     


Glu Arg Val Phe Glu Gln Phe Tyr Ile Arg Tyr Ile Asn Gln Arg Asn 
            740                 745                 750         


Lys Val Leu Asn Val Phe Leu Thr Thr Ile Arg His Asn Leu Asn Glu 
        755                 760                 765             


Pro Arg Ala Leu Lys Lys Val Leu Lys Asp Val Phe Thr Val Phe Asp 
    770                 775                 780                 


Lys Arg Leu Tyr Gln Ile Asn Ser Thr Asn Lys Gln Lys Asp Ala Leu 
785                 790                 795                 800 


Leu Thr Lys Pro Phe Ala Leu Ser Arg Gly Ile Phe Asp Asp Lys Pro 
                805                 810                 815     


Thr Val Val Pro Gly His Arg Pro Gln Asp Asn Pro Glu Leu Phe Ala 
            820                 825                 830         


Asp Trp Tyr Val Tyr Gly Tyr His Tyr Asn Gly Ala Phe Gln Ala Phe 
        835                 840                 845             


Tyr Glu Thr Ala Arg Glu Tyr Asp Gln Trp Tyr Thr Gln Lys Lys Lys 
    850                 855                 860                 


Glu Gly Ala Leu Pro Ala Phe Ser Gly Lys Asp Glu Ala Tyr Lys Ile 
865                 870                 875                 880 


Gln Arg Phe Arg Lys Asp Cys Asp Leu Asn Ile Lys Arg Ile Lys Phe 
                885                 890                 895     


Gln Asp Val Tyr Thr Lys Leu Met Val Asp Phe Leu Phe Glu Lys Thr 
            900                 905                 910         


Phe Asn Gly Glu Lys Leu Leu Phe Asp Leu Ser Lys Leu Tyr Glu Ser 
        915                 920                 925             


Arg Glu Gln Arg Leu Ala Asn Gln Ile Lys Ala Leu Gln Gln Lys Asp 
    930                 935                 940                 


Arg Pro Glu Gly Asp Ile Ser Glu Asn Ile Arg Asn Glu Asn Tyr Ile 
945                 950                 955                 960 


Trp Asn Lys Thr Val Asp Ile Thr Leu Leu Glu Gly Arg Ile Val Glu 
                965                 970                 975     


Lys Asn Ile Lys Leu Lys Asp Leu Gly Lys Phe Arg Arg Phe Val Thr 
            980                 985                 990         


Asp Gln Lys Val Glu Ala Leu Leu  Ser Tyr Asp Thr Lys  Thr Trp Ser 
        995                 1000                 1005             


Lys Gln  Asn Leu Glu Asp Glu  Leu Glu Asn Asp Lys  Asp Cys Tyr 
    1010                 1015                 1020             


Glu Ala  Ile Arg Arg Lys Val  Leu Leu Met His Ile  Gln Gln Phe 
    1025                 1030                 1035             


Glu Lys  Val Ile Leu Glu Lys  Gly Gly Phe Asp Gly  Lys Asn His 
    1040                 1045                 1050             


Pro Glu  Asp Phe Met Val Lys  Gly Ser Pro Asn Phe  Arg Met Tyr 
    1055                 1060                 1065             


Ile Ile  Asn Gly Val Leu Arg  Arg Ile Gly Gly Ile  Ser Glu Gly 
    1070                 1075                 1080             


Asp Leu  Gln Leu Leu Asn Asp  Met Pro Phe Glu Lys  Ile Thr Ile 
    1085                 1090                 1095             


Lys Glu  Val Glu Lys Met Asn  Glu Leu Ser Gln Lys  Ala Tyr Leu 
    1100                 1105                 1110             


Leu Ile  Tyr Leu Arg Asn Lys  Phe Gly His Asn Gln  Leu Pro Asp 
    1115                 1120                 1125             


Lys Glu  Arg Tyr Asp Leu Met  Arg Lys Leu Tyr Pro  Asp Cys Ile 
    1130                 1135                 1140             


Ile Ser  Thr Phe Ser Ser Phe  Phe Asn Lys Val Thr  Met Leu Ile 
    1145                 1150                 1155             


Ile Glu  Glu Leu Lys Met Leu  Ile 
    1160                 1165     


<210>  2581
<211>  1120
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2581

Met Glu Asp Asp Lys Lys Thr Thr Asp Ser Ile Ser Tyr Ala Leu Lys 
1               5                   10                  15      


Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val 
            20                  25                  30          


Tyr Ile Thr Val Asn His Ile Asn Lys Ile Leu Glu Glu Asp Glu Ile 
        35                  40                  45              


Asn Arg Asp Gly Tyr Glu Asn Thr Leu Glu Asn Ser Trp Asn Glu Ile 
    50                  55                  60                  


Lys Asp Ile Asn Lys Lys Asp Arg Leu Ser Lys Leu Ile Ile Lys His 
65                  70                  75                  80  


Phe Pro Phe Leu Glu Ala Ala Thr Tyr Arg Gln Asn Pro Thr Asp Thr 
                85                  90                  95      


Thr Lys Gln Lys Glu Glu Lys Gln Ala Glu Ala Gln Ser Leu Glu Ser 
            100                 105                 110         


Leu Lys Lys Ser Phe Phe Val Phe Ile Tyr Lys Leu Arg Asp Leu Arg 
        115                 120                 125             


Asn His Tyr Ser His Tyr Lys His Ser Lys Ser Leu Glu Arg Pro Lys 
    130                 135                 140                 


Phe Glu Glu Asp Leu Gln Asn Lys Met Tyr Asn Ile Phe Asp Val Ser 
145                 150                 155                 160 


Ile Gln Phe Val Lys Glu Asp Tyr Lys His Asn Thr Asp Ile Asn Pro 
                165                 170                 175     


Lys Lys Asp Phe Lys His Leu Asp Arg Lys Arg Lys Gly Lys Phe His 
            180                 185                 190         


Tyr Ser Phe Ala Asp Asn Glu Gly Asn Ile Thr Glu Ser Gly Leu Leu 
        195                 200                 205             


Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Val Gln 
    210                 215                 220                 


Lys Lys Leu Glu Gly Phe Lys Cys Ser Asn Glu Ser Tyr Gln Lys Met 
225                 230                 235                 240 


Thr Asn Glu Val Phe Cys Arg Ser Arg Met Leu Leu Pro Lys Leu Arg 
                245                 250                 255     


Leu Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu Asn 
            260                 265                 270         


Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Gln Gly Val 
        275                 280                 285             


Asn Arg Lys Lys Phe Tyr Val Ser Phe Asp Pro Ala Asp Glu Asp Tyr 
    290                 295                 300                 


Asp Ala Glu Gln Glu Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp 
305                 310                 315                 320 


Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Tyr Asn Glu Ile Phe 
                325                 330                 335     


Thr Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile 
            340                 345                 350         


Tyr Lys Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg His Leu Thr His 
        355                 360                 365             


Lys Leu Tyr Gly Phe Glu Arg Ile Gln Glu Phe Asp Lys Gln Asn Arg 
    370                 375                 380                 


Pro Asp Glu Trp Lys Ala Ile Val Lys Asp Ser Asp Thr Phe Lys Lys 
385                 390                 395                 400 


Lys Glu Glu Lys Glu Glu Glu Lys Pro Tyr Ile Ser Glu Thr Thr Pro 
                405                 410                 415     


His Tyr His Leu Glu Asn Lys Lys Ile Gly Ile Ala Phe Lys Asn His 
            420                 425                 430         


Asn Ile Trp Pro Ser Thr Gln Thr Glu Leu Thr Asn Asn Lys Arg Lys 
        435                 440                 445             


Lys Tyr Asn Leu Gly Thr Ser Ile Lys Ala Glu Ala Phe Leu Ser Val 
    450                 455                 460                 


His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Lys Thr Glu 
465                 470                 475                 480 


Asn Thr Lys Asn Asp Asn Lys Val Glu Gly Lys Lys Glu Thr Lys Lys 
                485                 490                 495     


Gln Gly Lys His Lys Ile Glu Ala Ile Ile Glu Ser Lys Ile Lys Asp 
            500                 505                 510         


Ile Tyr Ala Leu Tyr Asp Ala Phe Ala Asn Gly Glu Ile Asn Ser Glu 
        515                 520                 525             


Asp Glu Leu Lys Glu Tyr Leu Lys Gly Lys Asp Ile Lys Ile Val His 
    530                 535                 540                 


Leu Pro Lys Gln Met Ile Ala Ile Leu Lys Asn Glu His Lys Asp Met 
545                 550                 555                 560 


Ala Glu Lys Ala Glu Ala Lys Gln Glu Lys Met Lys Leu Ala Thr Glu 
                565                 570                 575     


Asn Arg Leu Lys Thr Leu Asp Lys Gln Leu Lys Gly Lys Ile Gln Asn 
            580                 585                 590         


Gly Lys Arg Tyr Asn Ser Ala Pro Lys Ser Gly Glu Ile Ala Ser Trp 
        595                 600                 605             


Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln Lys Asp Glu Asn 
    610                 615                 620                 


Gly Glu Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln Leu 
625                 630                 635                 640 


Leu Gln Arg Thr Leu Ala Phe Phe Gly Ser Glu His Glu Arg Leu Ala 
                645                 650                 655     


Pro Tyr Phe Lys Gln Thr Lys Leu Ile Glu Ser Ser Asn Pro His Pro 
            660                 665                 670         


Phe Leu Asn Asp Thr Glu Trp Glu Lys Cys Asn Asn Ile Leu Ser Phe 
        675                 680                 685             


Tyr Arg Ser Tyr Leu Glu Ala Lys Lys Asn Phe Leu Glu Ser Leu Lys 
    690                 695                 700                 


Pro Glu Asp Trp Glu Lys Asn Gln Tyr Phe Leu Met Leu Lys Glu Pro 
705                 710                 715                 720 


Lys Thr Asn Arg Lys Thr Leu Val Gln Gly Trp Lys Asn Gly Phe Asn 
                725                 730                 735     


Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg Lys Trp Phe Met Glu 
            740                 745                 750         


His Trp Lys Ser Ile Lys Val Asp Asp Ser Lys Arg Val Gly Leu Val 
        755                 760                 765             


Ala Lys Val Ile Pro Leu Phe Phe Ser Glu Lys Tyr Lys Asp Ser Val 
    770                 775                 780                 


Gln Pro Phe Tyr Asn Tyr Pro Phe Asn Val Gly Asp Val Asn Lys Pro 
785                 790                 795                 800 


Lys Glu Glu Asp Phe Leu His Arg Glu Glu Arg Ile Glu Leu Trp Asp 
                805                 810                 815     


Lys Lys Lys Asp Lys Phe Lys Gly Tyr Lys Ala Lys Lys Lys Phe Lys 
            820                 825                 830         


Glu Met Thr Asp Lys Glu Lys Glu Glu His Arg Ser Tyr Leu Glu Phe 
        835                 840                 845             


Gln Ser Trp Asn Lys Phe Glu Arg Glu Leu Arg Leu Val Arg Asn Gln 
    850                 855                 860                 


Asp Ile Val Thr Trp Leu Leu Cys Thr Glu Leu Ile Asp Lys Leu Lys 
865                 870                 875                 880 


Ile Asp Glu Leu Asn Ile Lys Glu Leu Lys Lys Leu Arg Leu Lys Asp 
                885                 890                 895     


Ile Asn Thr Asp Thr Ala Lys Glu Glu Lys Asn Asn Ile Leu Asn Arg 
            900                 905                 910         


Val Met Pro Met Glu Leu Pro Val Thr Val Tyr Glu Val Asn Lys Gly 
        915                 920                 925             


Gly Tyr Ile Ile Lys Asn Lys Pro Leu His Thr Ile Tyr Ile Lys Glu 
    930                 935                 940                 


Ala Glu Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys 
945                 950                 955                 960 


Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Val Lys Thr Pro Ser Glu 
                965                 970                 975     


Ala Glu Ser Glu Ser Asn Pro Ile Ser Lys Ser Arg Val Glu Ser Glu 
            980                 985                 990         


Leu Gly Lys Tyr Gln Asn Ala Arg  Leu Asp Ile Ile Glu  Asp Met Leu 
        995                 1000                 1005             


Ala Leu  Glu Lys Lys Leu Ile  Asp Lys Tyr Asn Ser  Leu Asp Thr 
    1010                 1015                 1020             


Asp Asn  Phe His Asn Met Leu  Thr Gly Trp Leu Glu  Leu Lys Gly 
    1025                 1030                 1035             


Glu Ala  Asn Lys Ala Arg Phe  Gln Asn Asp Val Lys  Leu Leu Thr 
    1040                 1045                 1050             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asn 
    1055                 1060                 1065             


Glu Asn  Leu Phe Gly Asn Ile  Glu Arg Phe Ser Leu  Ser Ser Ser 
    1070                 1075                 1080             


Asn Ile  Ile Glu Ser Lys Gly  Leu Asn Ile Ala Val  Lys Leu Lys 
    1085                 1090                 1095             


Glu Glu  Val Ser Lys Ala Ala  Lys Lys Ile Gln Asn  Glu Glu Asp 
    1100                 1105                 1110             


Asn Lys  Lys Glu Lys Glu Thr  
    1115                 1120 


<210>  2582
<211>  985
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2582

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Asn Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys Gly Tyr 
                165                 170                 175     


Ala Phe Phe Ile Ser Lys Phe Leu Glu Arg Lys Tyr Ser Tyr Leu Phe 
            180                 185                 190         


Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln Tyr Arg 
        195                 200                 205             


Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro Val Glu 
    210                 215                 220                 


Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu Asp Ile 
225                 230                 235                 240 


Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr Leu Glu 
                245                 250                 255     


Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr Asp Ala 
            260                 265                 270         


Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe Arg Ser 
        275                 280                 285             


Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala Asp Phe 
    290                 295                 300                 


Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His Asn Gly 
305                 310                 315                 320 


Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr Ile Asn 
                325                 330                 335     


Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser Ala Lys 
            340                 345                 350         


Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser Thr Asp 
        355                 360                 365             


Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln Ser Thr 
    370                 375                 380                 


Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val Leu Pro 
385                 390                 395                 400 


Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala Lys Met 
                405                 410                 415     


Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala Met Leu 
            420                 425                 430         


Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His Cys Pro 
        435                 440                 445             


Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser Thr Lys 
    450                 455                 460                 


Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg Val Met 
465                 470                 475                 480 


Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu Arg Ile 
                485                 490                 495     


Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile Leu Lys 
            500                 505                 510         


Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp Leu Gln 
        515                 520                 525             


Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn Phe Gln 
    530                 535                 540                 


Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn Asp Leu 
545                 550                 555                 560 


Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn Pro His 
                565                 570                 575     


Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile Glu Phe 
            580                 585                 590         


Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg Ile Gln 
        595                 600                 605             


Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro Leu Arg 
    610                 615                 620                 


Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu Ala Ile 
625                 630                 635                 640 


Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys Leu Lys 
                645                 650                 655     


Lys Ser Lys Leu Lys His Leu Ile Glu Ser Pro Thr Arg Glu Lys Ser 
            660                 665                 670         


Pro Ala Leu Asn Val Ser Tyr Leu Ile His Asn Tyr Phe Arg Ala Tyr 
        675                 680                 685             


Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn Tyr Arg 
    690                 695                 700                 


Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser Tyr Leu 
705                 710                 715                 720 


Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro Ser Lys 
                725                 730                 735     


Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp Arg Leu 
            740                 745                 750         


Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile Ile Arg 
        755                 760                 765             


Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys Glu Tyr 
    770                 775                 780                 


Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu Glu Asn 
785                 790                 795                 800 


Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp Leu Asn 
                805                 810                 815     


Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr Gly Lys 
            820                 825                 830         


Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn Lys Val 
        835                 840                 845             


Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val Lys Ile 
    850                 855                 860                 


Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu Glu Ala 
865                 870                 875                 880 


Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala Met Val 
                885                 890                 895     


Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr Tyr Asp 
            900                 905                 910         


Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln Lys Ile 
        915                 920                 925             


Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His Asp Lys 
    930                 935                 940                 


Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val Tyr Ala 
945                 950                 955                 960 


Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile Lys Leu 
                965                 970                 975     


Glu Asp Leu Ser Asn Asp Ser Ser Ala 
            980                 985 


<210>  2583
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2583

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Met Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Met Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Val Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2584
<211>  1131
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2584

Met Glu Lys Thr Ile Glu Asn Gln Thr Gln Ser Lys Arg Thr Leu Asn 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Asp Glu Glu Lys Ile Thr Thr Ser Phe Leu Val Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Arg Gln Ser Leu Val Tyr Ser Asn Leu Thr 
65                  70                  75                  80  


Arg Tyr Met His Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Asp 
                85                  90                  95      


Asp Glu Arg Asp Lys Ala Glu Asn Tyr Gly Lys Asp Phe Gly Asn Leu 
            100                 105                 110         


Thr Asp Thr Leu Lys Glu Ile Phe Lys Glu Leu Asn Glu Phe Arg Asn 
        115                 120                 125             


Asp Tyr Ser His Tyr Tyr Ser Thr Glu Lys Lys Asp Lys Arg Lys Thr 
    130                 135                 140                 


Ile Val Ser Asp Lys Leu Lys Asn Phe Leu Asn Ile Asn Tyr Thr Arg 
145                 150                 155                 160 


Ala Ile Lys Tyr Thr Lys Ser Arg Phe Ile Asn Val Phe Ser Asp Asn 
                165                 170                 175     


Asn Phe Cys Leu Ala Glu Glu Ala Lys His Val Glu Asn Asp Asn Thr 
            180                 185                 190         


Ile Thr Gln Asp Gly Ile Val Phe Phe Thr Ser Met Phe Leu Asp Arg 
        195                 200                 205             


Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile Ile Gly Leu Lys Gly Thr 
    210                 215                 220                 


Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Thr Leu Met Ala Phe Cys 
225                 230                 235                 240 


Val Asn Leu Pro His Asp Lys Phe Val Ser Glu Asn Ser Glu Gln Gln 
                245                 250                 255     


Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu 
            260                 265                 270         


Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln His Phe Leu Pro Lys Leu 
        275                 280                 285             


Asp Asp Glu Gln Ile Asp Asn Val Leu Glu Asn Ser Val Pro Tyr Thr 
    290                 295                 300                 


Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn Ile Thr Lys Lys Val Arg 
305                 310                 315                 320 


Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu Lys Phe Ile Asp Gln Lys 
                325                 330                 335     


Lys Leu Phe Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val 
            340                 345                 350         


Leu Asp Glu Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Lys Arg Thr 
        355                 360                 365             


Val Thr Glu Asn Thr Lys Ala Phe Gly Met Leu Gln Asp Leu Asn Asp 
    370                 375                 380                 


Glu Glu Asn Val Leu Asn Lys Ile Asn Thr Gly Glu Ser Lys Ala Lys 
385                 390                 395                 400 


Phe Asp Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Thr Lys Asn 
            420                 425                 430         


Thr Asp Asn Lys Ile Lys Ser Asn Leu Leu Gln Pro Leu Pro Glu Ala 
        435                 440                 445             


Phe Leu Ser Ile Asn Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
    450                 455                 460                 


Glu Gln Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn 
465                 470                 475                 480 


Asn Ser Lys Ile Leu Asn Lys Glu Phe Ile Lys Ala Ile Lys Leu Lys 
                485                 490                 495     


Leu Asn Asp Leu Asp Val Phe Tyr Lys Arg Ser Gln Gly Arg Lys Gln 
            500                 505                 510         


Lys His Ala Tyr Leu Thr Lys Asp Lys Lys Tyr Asp Asn Glu Lys Ile 
        515                 520                 525             


Asn Glu Leu Lys Asn Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu 
    530                 535                 540                 


Tyr Asn Leu Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp 
545                 550                 555                 560 


Leu Asn Ile Ala Asp Val Gln Ala Lys Asn Ala Ile Ser Asp Arg Ile 
                565                 570                 575     


Lys Leu Met Lys Arg Asp Cys Ile Asn Arg Leu Lys Ser Met Lys Lys 
            580                 585                 590         


Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp 
        595                 600                 605             


Ile Val Asp Met Ile Ile Asp Glu Glu Lys Lys Lys Lys Ile Thr Ser 
    610                 615                 620                 


Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Lys 
625                 630                 635                 640 


Glu Lys Lys Glu Leu Phe Ile Leu Ile Cys Asn Asn Glu Leu Lys Leu 
                645                 650                 655     


Asn Asp Asp Asp Gly His Pro Phe Phe Lys Asn Ile Asn Phe Ser Asn 
            660                 665                 670         


Tyr Lys Tyr Thr Ser Glu Ile Tyr Gln Lys Tyr Leu Glu Glu Lys Gly 
        675                 680                 685             


His Lys Met Val Lys Glu Tyr Asn Pro Arg Lys Glu Asn Tyr Val Glu 
    690                 695                 700                 


Lys Asp Lys Ser Trp Leu Glu Ile Asn Phe Tyr Lys Lys Glu Trp Asn 
705                 710                 715                 720 


Glu Asn Ala Lys Lys Asp Leu Thr Val Val Lys Leu Pro Asp Asp Lys 
                725                 730                 735     


Ser Lys Ile Pro Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser 
            740                 745                 750         


Phe Glu Asn Trp Phe Lys Tyr Val Thr Asn Gly Lys Glu Thr Thr Asp 
        755                 760                 765             


Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp Glu Thr Leu 
    770                 775                 780                 


Lys Glu Leu Leu Lys Lys Glu Leu Ser Lys Asn Asn Ile Glu Phe Lys 
785                 790                 795                 800 


Glu Glu Asp Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Asp Lys Cys 
                805                 810                 815     


Arg Asn Asp Lys Thr Gln Lys Phe Tyr Ser Ala Glu Arg Glu Tyr Thr 
            820                 825                 830         


Phe Glu Glu Glu Lys Leu Asn Phe His Ile Asn Thr Lys Ser Lys Phe 
        835                 840                 845             


Glu Glu Tyr Ile Asn Pro Glu Phe Ala Glu Lys Val Phe Arg Leu Lys 
    850                 855                 860                 


Asn Gln Asn Arg Glu Lys Asp Asn Ile Ser Gly Arg Arg Leu Pro Pro 
865                 870                 875                 880 


Leu Lys Met Lys Glu Val Thr Lys Asn Met Val Lys Arg Ile Gly Asn 
                885                 890                 895     


Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Leu Met Leu 
            900                 905                 910         


Leu Met Phe Glu Lys Leu Val Asp Asn Asn Leu Lys Leu Lys Leu Glu 
        915                 920                 925             


Asn Val Asp Lys Leu Leu Asn Glu Ser Ile Glu Ile Asn Gln Ser Ile 
    930                 935                 940                 


Ser Gly Lys Leu Ser Phe Asp Asp Ser Gly Asp Asn Glu Asn Lys Lys 
945                 950                 955                 960 


Asp Arg Ala Ile Ile Cys Arg Asn Ile Thr Glu Thr Arg Lys Arg Lys 
                965                 970                 975     


Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Glu Glu Glu  Asn Ile Pro Ile Glu  Lys Ile Lys 
        995                 1000                 1005             


Ile Glu  Leu Asp Thr Tyr Ser  Lys Ala Lys Asp Val  Val Phe Asp 
    1010                 1015                 1020             


Leu Ile  Phe Asp Leu Glu Arg  Ala Ile Ile Asn Lys  Asp Glu Asn 
    1025                 1030                 1035             


Arg Ile  Lys Glu Leu Asn Lys  Asp Lys Asn Gly Val  Ile Gln Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Phe Trp Leu  Leu Glu Lys 
    1055                 1060                 1065             


Asn Leu  Ile Thr Glu Gln Glu  Phe Thr Phe Met Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Thr  Phe Ser His Asn Gln  Phe Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Leu Phe  Ile Lys Asn Trp Asn  Glu Asn Glu Phe Ala  Lys Gln Ile 
    1100                 1105                 1110             


Leu Asn  Val Tyr Asn Gln Lys  Asn Asn Asn Leu Ile  Lys Ser Ile 
    1115                 1120                 1125             


Lys Asp  Ile 
    1130     


<210>  2585
<211>  1023
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2585

Met Asp Ala Pro Ile Asn Asn Lys Pro Leu Phe Ala Ala Tyr Leu Asn 
1               5                   10                  15      


Met Ala Arg Asn Asn Cys His Ile Ala Leu Ser His Ile Ala Glu Lys 
            20                  25                  30          


Thr His Lys Asp Gly Gly Ile Asn Glu Asp Ala Met His Asn Cys Ala 
        35                  40                  45              


Val Ile Gly Ile Leu Gln Ala Asp Lys Arg Pro Asp Glu Ser Arg Arg 
    50                  55                  60                  


Ile Val Glu Leu Ile Asp Gln His Phe Pro Phe Ala Lys Leu Phe Ile 
65                  70                  75                  80  


His Asn Arg Ile Asn Pro Ala Pro Ala Asp Tyr Ala Leu Leu Leu Ile 
                85                  90                  95      


Asn Phe Ile Phe Gln Leu Asn Gln Leu Arg Asn Phe Tyr Thr His His 
            100                 105                 110         


Thr His Lys Pro Tyr Thr Thr Asp Glu Lys Ile Met Gly Gln Leu Gln 
        115                 120                 125             


Phe Leu Phe Asp Val Ser Arg Arg Lys Val Arg Gln Arg Phe Ser Leu 
    130                 135                 140                 


His Gln Asp Asp Val Lys His Leu Val Arg Lys Thr Thr Lys Ile Ile 
145                 150                 155                 160 


Asn Gly Glu Arg Thr Ala Val Glu Lys Glu Asn Tyr Pro Tyr Ala Phe 
                165                 170                 175     


Ala Asp Lys Asn Gly Ser Phe Thr Glu Lys Gly Leu Ala Phe Phe Ile 
            180                 185                 190         


Cys Leu Phe Leu Glu Lys Lys Tyr Gly Tyr Leu Phe Leu Lys Gln Leu 
        195                 200                 205             


Arg Gly Phe Lys Asn Ser Ser Thr Lys Gln Thr Lys Ala Thr Leu Glu 
    210                 215                 220                 


Ala Tyr Cys Phe Phe His Ile Lys Val Pro Gln Pro Lys Leu Gln Ser 
225                 230                 235                 240 


Thr Asn Thr Asp Ile Ser Tyr Leu Leu Asp Val Leu Glu Glu Leu Lys 
                245                 250                 255     


Arg Cys Pro Asp Glu Leu Tyr Ser His Leu Ser Glu Thr Asp Lys Lys 
            260                 265                 270         


Ser Phe Ile Ser Ile Asp Glu Ala Asp Gln Asp Glu Glu Gln Pro Glu 
        275                 280                 285             


Asn Ile Leu Lys Arg Tyr Asn Asp Arg Phe Pro Tyr Phe Ala Leu Arg 
    290                 295                 300                 


Tyr Leu Glu Leu Thr Asn Ala Leu Gly Gly Leu Gln Phe Tyr Tyr Asp 
305                 310                 315                 320 


Leu Gly Lys Tyr Tyr Phe Lys Val Tyr Glu Lys Ala Val Asp Gly Glu 
                325                 330                 335     


Met Arg Leu Arg Arg Leu His Lys Asp Met Arg Gly Phe Gly Arg Leu 
            340                 345                 350         


Ala Asp Phe Lys Val Glu Asn Met Pro Glu Pro Trp Pro Gln Leu Ser 
        355                 360                 365             


Lys Arg Thr Asp Glu Leu Ala Glu Asn Tyr Ala Glu Pro Tyr Ile Ala 
    370                 375                 380                 


Tyr Thr Ile Pro His Tyr His Ile Val Asn Asn Gln Ile Gly Leu Cys 
385                 390                 395                 400 


Leu Gly Pro Lys Gln Ile Pro Ser Leu Ser Ser Pro Leu Gly Ser Pro 
                405                 410                 415     


Glu Pro Asp Met Trp Leu Ser Ile Tyr Glu Leu Pro Ala Leu Ile Phe 
            420                 425                 430         


Tyr His Leu Leu Thr Lys Gly Asp Asn Lys Ile Lys Ser Ala Lys Glu 
        435                 440                 445             


Val Leu Ser Thr His Cys Lys Ala Ile Arg Leu Leu Phe Ser Asn Ile 
    450                 455                 460                 


Lys Asp Lys Lys Leu Val Pro Gly Tyr Glu Arg Glu Ser Leu Ala Ala 
465                 470                 475                 480 


Glu Leu Lys Ser Arg Asn Leu Asp Thr Asp Gln Val Pro Ser Val Leu 
                485                 490                 495     


Leu Glu Tyr Leu Leu Gly Gln Ser Pro Ser Ile Ser Ala Ile Gln Lys 
            500                 505                 510         


Ala Gln Ser Arg Leu Lys Glu Leu Lys Asn Glu Thr Glu Leu Leu Lys 
        515                 520                 525             


Asn Lys Ile Asp Ile Asp Ile Gln Arg Ser Lys Glu Lys Val Gly Ser 
    530                 535                 540                 


Lys Val Tyr Arg Pro Ile Lys Thr Gly Lys Ile Ala Asp Phe Leu Ala 
545                 550                 555                 560 


Arg Asp Met Leu Leu Phe Gln Pro Pro Ile Asp Lys Ile Lys Gly Lys 
                565                 570                 575     


Ala Thr Ser Thr Leu Phe Gln Val Leu Gln Ala Arg Leu Ala Phe Tyr 
            580                 585                 590         


Gly Arg Asp Lys His Leu Leu His Asn Leu Tyr Lys Glu Cys Asn Leu 
        595                 600                 605             


Met Asp Ser Lys Asn Pro His Pro Phe Leu Asn Glu Leu Ser Ile Thr 
    610                 615                 620                 


Asp Ser Leu Ile Glu Tyr Tyr Arg Asn Tyr Leu Phe Lys Arg Glu Ala 
625                 630                 635                 640 


Tyr Leu Asp Lys Cys Leu Lys Lys Cys Met Gln Gly Lys Ile Gly Ser 
                645                 650                 655     


Pro Glu Leu His Phe Leu His Leu Gly Glu Arg Glu Lys Arg Asn Gly 
            660                 665                 670         


Ala Asp Tyr Tyr Ile Lys Leu Ala Glu Lys Phe Leu Thr Met Pro Ile 
        675                 680                 685             


Asn Leu Pro Arg Gly Ile Phe Met Asp Ala Leu Ile Arg His Phe Lys 
    690                 695                 700                 


Gln Ala Glu Asn Glu Ala Phe Lys Asn Leu Val Lys Thr Asp Arg Val 
705                 710                 715                 720 


Asn Thr Ser Phe Leu Leu Gln Glu Tyr Leu Thr Lys Ile Leu Ser Asp 
                725                 730                 735     


Asn Thr Gln Asn Phe Tyr Asn Leu Lys Arg Thr Tyr Arg Val Phe Asn 
            740                 745                 750         


Asn Tyr Tyr Asp Asn Arg Lys Pro Asn Ser Arg Asp Gly Leu Ser Glu 
        755                 760                 765             


Leu Tyr Phe Asn Val Pro Gln Leu Ser Leu Glu Ser Glu Lys Ile Lys 
    770                 775                 780                 


Ala Ala Ile Leu Lys Thr Lys Asp Pro Glu Val Lys Glu Asn Val His 
785                 790                 795                 800 


Arg Asn Tyr Lys Tyr Tyr Thr Glu Asn Glu Lys Gln Ile Arg Lys Ala 
                805                 810                 815     


Lys Thr Cys Asp Ile Val Leu Phe Leu Ile Leu Arg Asp Leu Phe Pro 
            820                 825                 830         


Ser Leu Glu Ser Ser Val Phe Lys Gly Leu Ala Ile Asn Gln Ile Arg 
        835                 840                 845             


Leu Ala Asp Ile Leu Pro Asn Ala Glu Thr Gly Ile Leu Ser Gln Gln 
    850                 855                 860                 


Ile Glu Ile Lys Leu Pro Leu His Gly Lys Phe Ile Val Gln Arg Asn 
865                 870                 875                 880 


Ile Lys Leu Lys Asn Tyr Gly Asp Phe Arg Arg Phe Leu Lys Asp Arg 
                885                 890                 895     


Arg Leu Glu Ser Leu Leu Pro Tyr Phe Glu Glu Glu Tyr Ile Asp Arg 
            900                 905                 910         


Ala Lys Ile Glu Arg Glu Leu Glu Asp Tyr Asp Thr Ala Arg Val Leu 
        915                 920                 925             


Met His Ser Met Val Leu Glu Phe Glu Arg Gln Val Val Val Lys Asn 
    930                 935                 940                 


Lys Leu Asp Tyr Ala Ser Pro Glu Ser Gly Val Ile Asn Phe Glu Glu 
945                 950                 955                 960 


Ile Leu Asn Ser Phe Phe Gln Asn Asn Asp Thr Asn Ile Lys Arg Glu 
                965                 970                 975     


Gln Met Met Asn Leu Arg Asn Lys Phe Ser His Asn Gln Tyr Pro Asp 
            980                 985                 990         


Phe Ser Ile Phe Asn Glu Val Ile  Lys Ser Asn Thr Lys  Asp Ile Ser 
        995                 1000                 1005             


Ile Ala  Lys Lys Phe Ile Glu  Ile Ala Glu Gln Leu  Phe Leu Pro 
    1010                 1015                 1020             


<210>  2586
<211>  1091
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2586

Met Lys Glu Glu Glu Lys Gly Lys Thr Pro Val Val Ser Thr Tyr Asn 
1               5                   10                  15      


Lys Asp Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His 
            20                  25                  30          


Asn Val Tyr Ile Thr Val Asn His Ile Asn Lys Ile Leu Gly Glu Ala 
        35                  40                  45              


Glu Ile Asn Ile Asp Gly Tyr Asp Ile Ser Leu Lys Asn Ile Trp Ser 
    50                  55                  60                  


Gly Ile Arg Asp Ile Asn Lys Lys Ala Arg Leu Glu Glu Leu Met Ile 
65                  70                  75                  80  


Lys His Phe Pro Phe Leu Glu Ala Met Thr His Gln Gln Arg Leu Thr 
                85                  90                  95      


Gly Asn Thr Lys Gln Lys Glu Glu Lys Gln Ala Lys Ile Gln Ser Phe 
            100                 105                 110         


Glu Ile Leu Lys Asp Asn Leu Phe Leu Leu Leu Lys Met Leu Gln Asp 
        115                 120                 125             


Leu Arg Asn His Tyr Ser His Tyr Lys His Ser Lys Ser Leu Glu Arg 
    130                 135                 140                 


Pro Lys Phe Asp Glu Asp Ile Arg Asn Lys Leu Tyr Asn Ile Phe Asp 
145                 150                 155                 160 


Thr Ser Ile Arg Leu Val Lys Glu Asp Tyr Lys His Asn Pro Asp Ile 
                165                 170                 175     


Lys Pro Lys Glu His Phe Lys His Leu Asp Arg Lys Arg Asn Glu Lys 
            180                 185                 190         


Phe Arg Tyr Ser Phe Ala Asp Asn Glu Gly Asn Ile Thr Ile Ser Gly 
        195                 200                 205             


Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp 
    210                 215                 220                 


Val Gln Lys Lys Leu Glu Gly Phe Arg Cys Ser Asn Glu Ser Tyr Gln 
225                 230                 235                 240 


Lys Met Thr Asn Glu Val Phe Cys Arg Asn Arg Ile Leu Met Pro Lys 
                245                 250                 255     


Leu Arg Leu Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met 
            260                 265                 270         


Leu Asn Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Lys 
        275                 280                 285             


Gly Glu Asp Arg Lys Lys Phe Glu Val Pro Phe Asp Ser Thr Asp Glu 
    290                 295                 300                 


Asp Tyr Asp Ala Glu Gln Asp Pro Phe Lys Asn Thr Leu Ile Arg Tyr 
305                 310                 315                 320 


Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe Asp Tyr Asn Glu 
                325                 330                 335     


Ile Phe Glu Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe 
            340                 345                 350         


Ser Ile Tyr Lys Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg His Leu 
        355                 360                 365             


Thr His Lys Leu Tyr Gly Phe Glu Arg Leu Gln Glu Phe Ala Lys Gln 
    370                 375                 380                 


Asn Arg Pro Asp Glu Trp Lys Ala Ile Ile Lys Asp Leu Asp Thr Phe 
385                 390                 395                 400 


Lys Lys Gln Glu Asp Glu Lys Val Asn Glu Lys Pro Tyr Ile Ser Glu 
                405                 410                 415     


Thr Thr Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Ala Phe 
            420                 425                 430         


Lys Asn His Asn Ile Trp Pro Thr Thr Asn Thr Glu Phe Thr Asn Asn 
        435                 440                 445             


Lys Arg Lys Lys Tyr Asn Leu Gly Thr Ser Ile Lys Ala Glu Ala Phe 
    450                 455                 460                 


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Met Leu Leu 
465                 470                 475                 480 


Lys Ile Lys Asn Glu Gly Pro Arg Lys Val Glu Ala Ile Ile Glu Ser 
                485                 490                 495     


Lys Ile Lys Asp Ile Phe Thr Leu Tyr Asp Ala Phe Ala Asn Asp Glu 
            500                 505                 510         


Ile Asp Asn Thr Asp Glu Leu Glu Lys Tyr Cys Glu Asp Lys Asp Ile 
        515                 520                 525             


Lys Ile Gly His Leu Pro Lys Gln Met Ile Ala Ile Leu Tyr Asn Lys 
    530                 535                 540                 


His Lys Asp Met Val Glu Lys Ala Lys Val Lys Gln Glu Lys Met Lys 
545                 550                 555                 560 


Leu Ala Thr Glu Asn Arg Leu Lys Thr Leu Asp Lys Leu Ile Glu Gly 
                565                 570                 575     


Lys Met Lys Tyr Ala Lys Arg Gly Ile Ser Pro Leu Lys Ser Gly Glu 
            580                 585                 590         


Ile Ala Ser Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln 
        595                 600                 605             


Arg Asp Glu Asn Gly Glu Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr 
    610                 615                 620                 


Glu Tyr Gln Leu Leu Gln Arg Thr Leu Ala Leu Phe Gly Ser Glu His 
625                 630                 635                 640 


Lys Arg Leu Thr Pro Tyr Phe Lys Gln Met Asn Leu Ile Gly Asp Asn 
                645                 650                 655     


Asn Ser His Pro Phe Leu Lys Gln Thr Glu Trp Glu Glu Cys Asn Asn 
            660                 665                 670         


Ile Leu Ser Phe Tyr Arg Ser Tyr Leu Glu Ala Arg Lys Asn Phe Leu 
        675                 680                 685             


Lys Asn Leu Glu Pro Lys Asp Trp Lys Lys Asn Gln Tyr Phe Leu Lys 
    690                 695                 700                 


Ile Lys Glu Pro Lys Ser Asn Arg Gln Thr Leu Val Gln Gly Trp Lys 
705                 710                 715                 720 


Asn Gly Phe Asn Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Lys Lys 
                725                 730                 735     


Trp Phe Ile Glu His Arg Lys Lys Met Lys Val Asp Glu Leu Lys Ser 
            740                 745                 750         


Val Gly Leu Val Ala Lys Val Ile Pro Leu Tyr Phe Asn Glu Lys Tyr 
        755                 760                 765             


Lys Asp Ser Val Gln Pro Phe Tyr Asn Tyr Pro Phe Asn Val Gly Asp 
    770                 775                 780                 


Ile Asn Lys Pro Lys Glu Lys Asp Phe Leu Asp Asn Gly Lys Arg Arg 
785                 790                 795                 800 


Lys Leu Trp Asp Lys Lys Gln Leu Glu Phe Lys Gly Lys Thr Glu Glu 
                805                 810                 815     


Glu Lys Arg Lys Asn Pro Ser Tyr Leu Asp Phe Lys Ser Trp Lys Lys 
            820                 825                 830         


Phe Glu Arg Glu Leu Arg Leu Ile Arg Asn Gln Asp Ile Val Thr Trp 
        835                 840                 845             


Leu Met Cys Ile Glu Leu Tyr Asn Asn Gln Lys Val Glu Asn Leu Asn 
    850                 855                 860                 


Thr Gly His Ile Tyr Leu Lys Asp Ile Ile Thr Asn Val Lys Glu Glu 
865                 870                 875                 880 


Arg Asn Asn Asn Ile Leu Asn Gln Ile Lys Ser Met Gln Leu Pro Val 
                885                 890                 895     


Thr Val Tyr Glu Asn Glu Ser Ser Pro Lys Lys Lys Tyr Leu Arg Thr 
            900                 905                 910         


Ile Tyr Ile Glu Glu Asn Gly Thr Lys Leu Leu Lys Gln Gly Asn Phe 
        915                 920                 925             


Lys Ala Leu Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Val 
    930                 935                 940                 


Lys Thr Ser Ser Glu Ala Glu Ser Lys Arg Asn Pro Ile Ser Lys Leu 
945                 950                 955                 960 


Arg Val Glu His Glu Leu Arg Glu Tyr Gln Lys Ala Arg Ile Asp Ile 
                965                 970                 975     


Ile Lys Asp Met Leu Ala Leu Glu Lys Thr Leu Ile Asp Asn Tyr Asp 
            980                 985                 990         


Ser Leu Asp Thr Asp Asn Phe His  Asn Met Leu Thr Gly  Trp Leu Glu 
        995                 1000                 1005             


Leu Lys  Gly Glu Ala Ile Lys  Thr Lys Phe Asn Asn  Asp Val Lys 
    1010                 1015                 1020             


Leu Leu  Thr Ala Val Arg Asn  Ala Phe Ser His Asn  Gln Tyr Pro 
    1025                 1030                 1035             


Met Tyr  Asp Glu Asn Leu Phe  Ile Asn Ile Glu Arg  Phe Ser Leu 
    1040                 1045                 1050             


Ser Ser  Ser Arg Ile Leu Glu  Ser Lys Gly Leu Gly  Ile Ala Val 
    1055                 1060                 1065             


Lys Leu  Lys Glu Glu Val Ser  Asn Ala Ile Glu Lys  Ile Lys Asn 
    1070                 1075                 1080             


Glu Glu  Asp Ala Lys Lys Glu  Thr 
    1085                 1090     


<210>  2587
<211>  1112
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2587

Met Glu Asn Gln Glu Leu Lys Thr Arg Thr Met Lys Ser Glu Pro Tyr 
1               5                   10                  15      


Tyr Tyr Gly Ala Phe Leu Asn Met Ala Arg Leu Asn Ile Phe Asn Ile 
            20                  25                  30          


Ser Asn His Leu Ser Asn Lys Leu Asn Ile Leu Pro Thr Leu Ser Ser 
        35                  40                  45              


Glu Glu His Ile Ala Asn Ala Phe Phe Thr Asp Lys Asn Thr Lys Ile 
    50                  55                  60                  


Lys Trp Glu His Thr Tyr Asp Ile Leu Arg Arg Phe Ile Pro Ile Val 
65                  70                  75                  80  


Lys Val Phe Asp Thr Glu Ser Leu Pro Lys Gly Glu Val Gly Asn Asn 
                85                  90                  95      


Thr Gly Lys Asp Phe Ser Lys Met Ser Asp Thr Leu Lys Ile Ile Phe 
            100                 105                 110         


Lys Glu Leu Asn Glu Phe Arg Asn Asp Tyr Ser His Tyr Tyr Ser Thr 
        115                 120                 125             


Glu Lys Glu Asp Lys Arg Lys Ile Thr Ile Ser Asp Glu Leu Ala Asn 
    130                 135                 140                 


Phe Leu Asn Glu Asn Phe Lys Arg Ala Ile Ala Tyr Thr Lys Lys Arg 
145                 150                 155                 160 


Phe Lys Gly Val Phe Thr Glu Lys Asp Phe Glu Leu Ala Asn Asn Ile 
                165                 170                 175     


Gln Leu Phe Asn Lys Asp Lys Glu Ile Thr Glu Lys Gly Leu Ala Phe 
            180                 185                 190         


Leu Thr Ser Ile Phe Leu Glu Arg Glu Tyr Ala Phe Gln Phe Ile Ser 
        195                 200                 205             


Lys Ile Glu Gly Leu Lys Gly Thr Gln Lys Ser Glu Tyr Arg Ala Thr 
    210                 215                 220                 


Arg Glu Val Phe Met Ala Tyr Cys Val Asn Leu Pro His Asp Lys Phe 
225                 230                 235                 240 


Ile Ser Glu Asp Ala Lys Gln Ser Phe Ser Leu Asp Ile Ile Ser Glu 
                245                 250                 255     


Leu Asn Arg Cys Pro Gln Thr Leu Phe Asn Val Ile Thr Glu Lys Glu 
            260                 265                 270         


Gln Glu Lys Phe Arg Pro Thr Ile Asn Gln Gln Glu Lys Asn Asn Ile 
        275                 280                 285             


Ile Asn Asn Ser Val Pro Tyr Asp Ile Glu Asp Tyr Glu Glu Tyr Val 
    290                 295                 300                 


Asn Ser Ile Thr Lys Lys Ile Arg Tyr Asp Asn Arg Phe Pro Phe Phe 
305                 310                 315                 320 


Ala Leu Lys Phe Ile Asp Glu Thr Gln Val Phe Glu Lys Ile Arg Phe 
                325                 330                 335     


Gln Ile Asp Leu Gly Glu Ile Leu Leu Asp Glu Tyr Thr Lys Gln Leu 
            340                 345                 350         


Ala Asn Asn Glu Glu Lys Arg Gln Val Val Gln Asn Ala Lys Ala Phe 
        355                 360                 365             


Gly Arg Leu Asn Asp Phe Ile Asp Glu Asn Asn Val Leu Glu Asn Ile 
    370                 375                 380                 


Asn Lys Gln Asn Gly Ser Ala Ser Phe Ile Gln Tyr Ala Pro Asn Tyr 
385                 390                 395                 400 


Asn Phe Asp Asn Asn Lys Ile Gly Ile Asp Thr Thr Gly Lys Arg Ile 
                405                 410                 415     


Met Pro Ile Leu Thr Lys Gln Thr Asp Asn Asn Lys Lys Val Lys Asn 
            420                 425                 430         


Lys Leu Lys Gln Pro Leu Pro Lys Ala Phe Leu Ser Ile His Glu Leu 
        435                 440                 445             


Pro Lys Ile Ile Leu Leu Glu Tyr Leu Glu Lys Gly Lys Ala Glu Lys 
    450                 455                 460                 


Leu Ile Asn Asp Phe Leu Leu Ile Asn Glu Ser Gln Leu Leu Asn Tyr 
465                 470                 475                 480 


Lys Tyr Ile Glu Glu Ile Lys Asn Lys Leu Asn Asn Phe Asp Val Phe 
                485                 490                 495     


Gln Lys Arg Ser Gln Arg Lys Lys Leu Gln Thr Ala Tyr Asn Lys Thr 
            500                 505                 510         


Asn Ile Glu Glu Leu Gln Ser Arg Lys Glu Glu Leu Asn Lys Ile Leu 
        515                 520                 525             


Lys Glu Tyr Lys Leu Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Glu 
    530                 535                 540                 


Tyr Trp Leu Asn Ile Glu Asp Val Thr Pro Asn Glu Ala Ile Ser Asp 
545                 550                 555                 560 


Arg Ile Lys Leu Met Lys Arg Asp Cys Val Asp Arg Leu Arg Asp Ile 
                565                 570                 575     


Lys Lys Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala 
            580                 585                 590         


Lys Asp Ile Val Asp Met Ile Ile Ser Lys Asp Ile Lys Gln Lys Ile 
        595                 600                 605             


Ser Ser Phe Tyr Tyr Asp Lys Ile Gln Glu Cys Leu Ala Leu Tyr Asn 
    610                 615                 620                 


Val Ser Glu Lys Arg Asp Leu Phe Leu Thr Ile Cys Asn Glu Leu Arg 
625                 630                 635                 640 


Leu Leu Asp Ala Asp Lys Gly His Pro Phe Leu Lys Asn Ile Asn Leu 
                645                 650                 655     


Asn Arg Ile Asn Tyr Thr Ser Asp Phe Tyr Val Lys Tyr Leu Gln Glu 
            660                 665                 670         


Lys Gly His Lys Leu Ile Lys Glu Thr Asn Tyr Arg Thr Gly Lys Leu 
        675                 680                 685             


Val Glu Lys Asp Lys Ser Trp Met Phe Leu Asn Phe Tyr Tyr Leu Lys 
    690                 695                 700                 


Lys Asn Glu Thr Leu Asn Lys Met Met Thr Ile Val Gln Leu Pro Asp 
705                 710                 715                 720 


Asp Lys Ser Lys Leu Pro Phe Thr Ile Ala Gln Leu Asp Lys Pro Lys 
                725                 730                 735     


Asn Thr Phe Glu Glu Trp Ile Asn Asn Ile Thr Lys Gly Lys Thr Lys 
            740                 745                 750         


Thr Asp Lys Glu Lys Pro Ile Asp Leu Pro Thr Asn Ile Phe Asp Lys 
        755                 760                 765             


Glu Ile Glu Glu Ile Leu Lys Asn Lys Leu Ser Glu Glu Lys Ile Ala 
    770                 775                 780                 


Phe Thr Glu Asn Ala Asn Tyr Asn Gln Leu Phe Lys Leu Trp Trp Thr 
785                 790                 795                 800 


Asp Cys Arg Lys Asp Asn Val Gln Lys Phe Tyr Asp Ala Glu Arg Glu 
                805                 810                 815     


Tyr Val Ile Tyr Asp Glu His Val Lys Phe Ile Pro Asn Thr Lys Pro 
            820                 825                 830         


Lys Phe Glu Asn Tyr Tyr Asn Glu Ser Phe Pro Ile Val Leu Thr Arg 
        835                 840                 845             


Leu Lys Arg Asp Arg Glu Glu Ala Arg Lys Leu Asn Arg Lys Leu Pro 
    850                 855                 860                 


Pro Ile Glu Lys Ser Gln Val Glu Lys Val Phe Lys Gln Ala Ile Gly 
865                 870                 875                 880 


Ser Thr Glu Lys Glu Ile Arg Leu Leu Gln Glu Glu Asp Arg Ile Met 
                885                 890                 895     


Leu Leu Met Phe Glu Gln Leu Leu Glu Thr Asp Asn Asn Leu Asn Leu 
            900                 905                 910         


Lys Leu Asn Asn Ala Glu Ser Leu Leu Asn Glu Gln Ile Thr Ile Lys 
        915                 920                 925             


Glu Lys Ile Ser Leu Lys Leu Ser Phe Asn Glu Gln Glu Asp Lys Lys 
    930                 935                 940                 


Glu Ile Ile Lys Thr Ile Ile Asp Lys Arg Lys Arg Lys Asp Phe Ser 
945                 950                 955                 960 


Ile Leu Arg Lys Phe Lys Tyr Asp Lys Arg Leu Pro Glu Leu Cys Glu 
                965                 970                 975     


Tyr Phe Glu Thr Asp Asp Ile Ser His Ser Asp Leu Lys Lys Glu Leu 
            980                 985                 990         


Asp Glu Tyr Asn Lys Ala Lys Glu  Gln Ile Leu Ala Asn  Ala Phe Met 
        995                 1000                 1005             


Leu Glu  Lys Thr Ile Ile Glu  Lys Asp Lys Asp Gly  Ile Lys Ala 
    1010                 1015                 1020             


Leu Phe  Leu Asn Asp Asn Gly  Glu Lys Lys Tyr Gly  Asn Val Gln 
    1025                 1030                 1035             


His Lys  Pro Tyr Leu Thr Trp  Leu Lys Asn Lys Gly  Leu Ile Asn 
    1040                 1045                 1050             


Asp Asn  Glu Tyr Leu Phe Ile  Asn Met Val Arg Asn  Thr Phe Ser 
    1055                 1060                 1065             


His Asn  Gln Phe Pro Gln Lys  Arg Thr Ile Gln Ile  Phe Ile Asp 
    1070                 1075                 1080             


Lys Asn  Arg Gly Asn Pro Ile  Thr Phe Ala Glu Thr  Ile Lys Asn 
    1085                 1090                 1095             


Ala Tyr  Asn Lys Lys Ile Glu  Glu Ile Ile Val Lys  Ile Lys 
    1100                 1105                 1110         


<210>  2588
<211>  1047
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2588

Met Glu Glu Gln Phe Leu Gln Lys Glu Arg Asn Met Gly Asp Asn Pro 
1               5                   10                  15      


Tyr Tyr Phe Cys His Phe Ile Asn Met Ala His His Asn Val Asn Leu 
            20                  25                  30          


Ile Leu Glu Glu Ile Tyr Asn Ser Val Tyr Glu Lys Tyr Thr Gln Asp 
        35                  40                  45              


Lys Glu Glu Asn Ile Lys Ala Ile Cys Asn Ser Met Ile Ser Lys Ser 
    50                  55                  60                  


Arg Lys Asn Pro Asp Glu Lys Ala Lys Met Met Asn Met Cys Ile Arg 
65                  70                  75                  80  


His Phe Pro Phe Leu Asp Tyr Tyr Lys Glu Lys Asp Gln Asn Ser Asp 
                85                  90                  95      


Val Leu Thr Ile Leu Leu Asn Gln Phe Leu Val Pro Leu His Gly Leu 
            100                 105                 110         


Arg Asn Gln Phe Ser His Tyr Lys His Pro Gln Glu Ala Tyr Cys Ile 
        115                 120                 125             


Ser Gly Phe Asp Leu Leu Phe Glu Gln Ala Lys Thr Gly Ala Gln Met 
    130                 135                 140                 


Arg Met Lys Tyr Ser Asp Glu Asp Ile Ser Lys Val Lys Ser Lys Val 
145                 150                 155                 160 


Val Asn His Asp Ser Ile Leu Thr Glu Arg Gly Ile Leu Phe Phe Ile 
                165                 170                 175     


Cys Leu Phe Leu Asp Lys Arg Asn Ile Tyr Leu Phe Leu Ser Lys Ile 
            180                 185                 190         


Lys Gly Phe Arg Asp Arg Arg Pro Asp Glu Lys Tyr Lys Ser Ala Thr 
        195                 200                 205             


Leu Glu Val Phe Ser Gln Tyr Tyr Cys His Val Pro Tyr Arg Lys Leu 
    210                 215                 220                 


Asp Ser Ser Asp Val Ala Leu Asp Met Leu Asn Glu Leu Asn Arg Cys 
225                 230                 235                 240 


Pro Lys Ala Leu Tyr Asp Val Leu Ser Asp Glu Asp Arg Glu Arg Phe 
                245                 250                 255     


Ile Val Asp Asn Val Glu Asn Ala Asp Asn Arg Asp Glu Ile Ser Asp 
            260                 265                 270         


Glu Asp Asp Glu Glu Met Pro Arg Ser Val Met Lys Arg Ser Asp Asp 
        275                 280                 285             


Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Glu Lys Gln Asn Asn Leu 
    290                 295                 300                 


Asp Glu Ile Ser Phe His Leu Tyr Leu Gly Arg Lys Glu Ala Lys Pro 
305                 310                 315                 320 


Ala His Glu Lys Val Ile Asn Gly Glu Met Arg Thr His Lys Ile Leu 
                325                 330                 335     


Lys Asp Ile His Val Phe Gly Arg Leu Glu Asn Tyr Arg Asn Glu Glu 
            340                 345                 350         


Ile Cys Asn Ala Ile Lys Asn Arg Glu Asp Ile Glu Phe Tyr Ala Pro 
        355                 360                 365             


Ser Tyr Arg Ile Val Glu Asn Arg Ile Gly Leu Leu Leu Arg Arg Gln 
    370                 375                 380                 


Asn Asp Phe Thr Leu Glu Glu Ala Asn Glu Glu Lys Ile Phe Glu Gly 
385                 390                 395                 400 


Asn Leu Cys Pro Asp Val Ile Leu Ser Thr His Glu Leu Gly Ala Leu 
                405                 410                 415     


Phe Phe Tyr Asn Tyr Leu His Lys Lys Gly Trp Ile Glu Ser Ala Pro 
            420                 425                 430         


Tyr Leu Tyr Ile Arg Asn Phe Ile Ser Asp Phe Lys Arg Phe Ile Glu 
        435                 440                 445             


Asp Ile Lys Asn Gly Lys Leu Thr Pro Val Glu Ser Glu Asp Asp Phe 
    450                 455                 460                 


Tyr Leu Ile Lys Lys Lys Lys Arg Asp Glu Thr Lys Asp Asn Asp Lys 
465                 470                 475                 480 


Lys Ser Ile Ala Val Gln Glu Arg Arg Arg Glu Lys Leu Lys Glu Lys 
                485                 490                 495     


Leu Lys Gly Tyr His Leu Glu Pro Asp Trp Ile Pro Asp Ala Cys Arg 
            500                 505                 510         


Glu Tyr Met Leu Gly Tyr Lys Ala Asp Gln Lys Asp Tyr Tyr Thr Lys 
        515                 520                 525             


Gln Arg Phe Cys Ser Met Lys Lys Glu Thr Asp Ser Arg Ile Lys Gln 
    530                 535                 540                 


Ile Glu Ala Ile Arg Lys Arg Glu Asp Asn Ser Ile Ile Arg Gln Thr 
545                 550                 555                 560 


Arg Val Gly Glu Ile Ala Gln Glu Leu Ala Arg Asp Ile Val Phe Leu 
                565                 570                 575     


Ile Pro Pro Tyr Lys Asn Glu Lys Gly Ala Asp Thr Lys Ile Asn Asn 
            580                 585                 590         


Met Glu Phe Asp Val Leu Gln Lys Met Leu Ala Tyr Phe Pro Leu Asn 
        595                 600                 605             


Lys Lys Asp Ile Tyr Pro Phe Leu Lys Asn Ile Arg Asn Trp Asp Lys 
    610                 615                 620                 


His Pro Phe Leu Lys Tyr Thr Leu His Thr Glu His Gln Ser Leu Leu 
625                 630                 635                 640 


Asp Phe Tyr Gln Asp Tyr Leu Asn Cys Lys Lys Arg Trp Ile Ser Lys 
                645                 650                 655     


Asn Ile Arg Tyr Asp Lys Gln Lys Gly Asn Tyr Leu Val Asp Ala Asn 
            660                 665                 670         


Lys Thr Glu Gln Glu Cys Arg Tyr Phe Leu Lys Thr Asp Lys Leu Arg 
        675                 680                 685             


Thr Ala Lys Glu Lys Glu Tyr Phe Glu Glu Pro Asp Lys Pro Val Tyr 
    690                 695                 700                 


Leu Pro Thr Gly Phe Phe Val Asp Pro Ile Val Glu Ala Met Arg Lys 
705                 710                 715                 720 


Asn Gly Tyr Glu Leu Lys Glu Asn Ser Asn Ile Val Gly Cys Leu Lys 
                725                 730                 735     


Ile Tyr Phe Val Ser Lys Ile Gln Pro Met Tyr Asp Leu Ser Arg Tyr 
            740                 745                 750         


Tyr Thr Tyr Tyr Asp Gly Lys Glu Glu Arg Ser Met Gln Leu Asp Asp 
        755                 760                 765             


Leu Lys Val Phe Ile Lys Glu Lys Phe Gly Asn Lys Arg Thr Asp Asp 
    770                 775                 780                 


Asn Thr Ile Arg Phe Leu Lys Lys Ala Ala Lys Arg Ile Arg Glu Asn 
785                 790                 795                 800 


Glu Ser Glu Ile Leu Val Arg Gln Met Asp Asp Cys Ala Leu Phe Leu 
                805                 810                 815     


Met Val Asn Asp Leu Leu Glu Gly Gly Lys Phe Asn Asp Glu Asp Ile 
            820                 825                 830         


Glu Asn Ile Gly Tyr Asn Lys His His Asn Leu Leu Asp His Glu Tyr 
        835                 840                 845             


Asp Met Cys Glu Thr Ile Tyr Gly Arg Lys Val Thr Ala Arg Leu Pro 
    850                 855                 860                 


Ile Lys Arg Tyr Gly Glu Phe Arg Arg Phe Met Lys Asp Arg Arg Leu 
865                 870                 875                 880 


Gln Asn Leu Val Lys Tyr Tyr Pro Gly Asp His Glu Thr Pro Ile Pro 
                885                 890                 895     


Ser Gly Ile Pro Glu Ser Gly Lys Ala Met Glu Lys Asn Lys Lys Tyr 
            900                 905                 910         


Thr Tyr Ser Asn Leu Cys Asp Glu Leu Glu Ile Tyr Asp Lys Glu Arg 
        915                 920                 925             


Asp Asn Val Leu Asn Leu Ile Tyr Glu Val Asp Lys Ile Leu Val Asp 
    930                 935                 940                 


His Phe Pro Asp Lys Ile Met Lys Glu Glu Asp Gly Tyr Tyr Glu His 
945                 950                 955                 960 


Tyr His Cys Leu Asp Phe Ala Lys Lys Glu Phe Gly Leu Glu Ser Asp 
                965                 970                 975     


Val Glu Leu Leu Ser Gln Asp Asn Phe Lys Asp Leu Arg Asn Ala Leu 
            980                 985                 990         


Tyr His Asn Gln Ile Pro Tyr Asn  Asp Trp Val Ala Asp  Lys Ile Ser 
        995                 1000                 1005             


Lys Asp  Thr Glu Glu Pro Met  Tyr Val Arg Arg Ile  Phe Ser Phe 
    1010                 1015                 1020             


Ile Arg  Thr Val Tyr Ser Arg  Leu Leu Asp Gln Ile  Lys Ile Lys 
    1025                 1030                 1035             


Ile Glu  Lys Asp Glu Tyr Lys  Cys Lys 
    1040                 1045         


<210>  2589
<211>  1047
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2589

Met Glu Glu Gln Phe Leu Gln Lys Glu Arg Asn Met Gly Asp Asn Pro 
1               5                   10                  15      


Tyr Tyr Phe Cys His Phe Ile Asn Met Ala His His Asn Val Asn Leu 
            20                  25                  30          


Ile Leu Glu Glu Ile Tyr Asn Ser Val Tyr Glu Lys Tyr Thr Gln Asp 
        35                  40                  45              


Lys Glu Glu Asn Ile Lys Ala Ile Cys Asn Ser Met Ile Ser Lys Ser 
    50                  55                  60                  


Arg Lys Asn Pro Asp Glu Lys Ala Lys Met Met Asn Met Cys Ile Arg 
65                  70                  75                  80  


His Phe Pro Phe Leu Asp Tyr Tyr Lys Glu Lys Asp Gln Asn Ser Asp 
                85                  90                  95      


Val Leu Thr Ile Leu Leu Asn Gln Phe Leu Val Pro Leu His Gly Leu 
            100                 105                 110         


Arg Asn Gln Phe Ser His Tyr Lys His Pro Gln Glu Ala Tyr Cys Ile 
        115                 120                 125             


Ser Gly Phe Asp Leu Leu Phe Glu Gln Ala Lys Thr Gly Ala Gln Met 
    130                 135                 140                 


Arg Met Lys Tyr Ser Asp Glu Asp Ile Ser Lys Val Lys Ser Lys Val 
145                 150                 155                 160 


Val Asn His Asp Ser Ile Leu Thr Glu Arg Gly Ile Leu Phe Phe Ile 
                165                 170                 175     


Cys Leu Phe Leu Asp Lys Arg Asn Ile Tyr Leu Phe Leu Ser Lys Ile 
            180                 185                 190         


Lys Gly Phe Arg Asp Arg Arg Pro Asp Glu Lys Tyr Lys Ser Ala Thr 
        195                 200                 205             


Leu Glu Val Phe Ser Gln Tyr Tyr Cys His Val Pro Tyr Arg Lys Leu 
    210                 215                 220                 


Asp Ser Ser Asp Val Ala Leu Asp Met Leu Asn Glu Leu Asn Arg Cys 
225                 230                 235                 240 


Pro Lys Ala Leu Tyr Asp Val Leu Ser Asp Glu Asp Arg Glu Arg Phe 
                245                 250                 255     


Ile Val Asp Asn Val Glu Asn Ala Asp Asn Arg Asp Glu Ile Ser Asp 
            260                 265                 270         


Glu Asp Asp Glu Glu Met Pro Arg Ser Val Met Lys Arg Ser Asp Asp 
        275                 280                 285             


Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Glu Lys Gln Asn Asn Leu 
    290                 295                 300                 


Asp Glu Ile Ser Phe His Leu Tyr Leu Gly Arg Lys Glu Ala Lys Pro 
305                 310                 315                 320 


Ala His Glu Lys Val Ile Asn Gly Glu Met Arg Thr His Lys Ile Leu 
                325                 330                 335     


Lys Asp Ile His Val Phe Gly Arg Leu Glu Asn Tyr Arg Asn Glu Glu 
            340                 345                 350         


Ile Cys Asn Ala Ile Lys Asn Arg Glu Asp Ile Glu Phe Tyr Ala Pro 
        355                 360                 365             


Ser Tyr Arg Ile Val Glu Asn Arg Ile Gly Leu Leu Leu Arg Arg Gln 
    370                 375                 380                 


Asn Asp Phe Thr Leu Glu Glu Ala Asn Glu Glu Lys Ile Phe Glu Gly 
385                 390                 395                 400 


Asn Leu Cys Pro Asp Val Ile Leu Ser Thr His Glu Leu Gly Ala Leu 
                405                 410                 415     


Phe Phe Tyr Asn Tyr Leu His Lys Lys Gly Trp Ile Glu Ser Ala Pro 
            420                 425                 430         


Tyr Leu Tyr Ile Arg Asn Phe Ile Ser Asp Phe Lys Arg Phe Ile Glu 
        435                 440                 445             


Asp Ile Lys Asn Gly Lys Leu Thr Pro Val Glu Ser Glu Asp Asp Phe 
    450                 455                 460                 


Tyr Leu Ile Lys Lys Lys Lys Arg Asp Glu Thr Lys Asp Asn Asp Lys 
465                 470                 475                 480 


Lys Ser Ile Ala Val Gln Glu Arg Arg Arg Glu Lys Leu Lys Glu Lys 
                485                 490                 495     


Leu Lys Gly Tyr His Leu Glu Pro Asp Trp Ile Pro Asp Ala Cys Arg 
            500                 505                 510         


Glu Tyr Met Leu Gly Tyr Lys Ala Asp Gln Lys Asp Tyr Tyr Thr Lys 
        515                 520                 525             


Gln Arg Phe Cys Ser Met Lys Lys Glu Thr Asp Ser Arg Ile Lys Gln 
    530                 535                 540                 


Ile Glu Ala Ile Arg Lys Arg Glu Asp Asn Ser Ile Ile Arg Gln Thr 
545                 550                 555                 560 


Arg Val Gly Glu Ile Ala Gln Glu Leu Ala Arg Asp Ile Val Phe Leu 
                565                 570                 575     


Ile Pro Pro Tyr Lys Asn Glu Lys Gly Ala Asp Thr Lys Ile Asn Asn 
            580                 585                 590         


Met Glu Phe Asp Val Leu Gln Lys Met Leu Ala Tyr Phe Pro Leu Asn 
        595                 600                 605             


Lys Lys Asp Ile Tyr Pro Phe Leu Lys Asn Ile Arg Asn Trp Asp Lys 
    610                 615                 620                 


His Pro Phe Leu Lys Tyr Thr Leu His Thr Glu His Gln Ser Leu Leu 
625                 630                 635                 640 


Asp Phe Tyr Gln Asp Tyr Leu Asn Cys Lys Lys Arg Trp Ile Ser Lys 
                645                 650                 655     


Asn Ile Arg Tyr Asp Lys Gln Lys Gly Asn Tyr Leu Val Asp Ala Asn 
            660                 665                 670         


Lys Thr Glu Gln Glu Cys Arg Tyr Phe Leu Lys Thr Asp Lys Leu Arg 
        675                 680                 685             


Thr Ala Lys Glu Lys Glu Tyr Phe Glu Glu Pro Asp Lys Pro Val Tyr 
    690                 695                 700                 


Leu Pro Thr Gly Phe Phe Val Asp Pro Ile Val Glu Ala Met Arg Lys 
705                 710                 715                 720 


Asn Gly Tyr Glu Leu Lys Glu Asn Ser Asn Ile Val Gly Cys Leu Lys 
                725                 730                 735     


Ile Tyr Phe Val Ser Lys Ile Gln Pro Met Tyr Asp Leu Ser Arg Tyr 
            740                 745                 750         


Tyr Thr Tyr Tyr Asp Gly Lys Glu Glu Arg Ser Met Gln Leu Asp Asp 
        755                 760                 765             


Leu Lys Val Phe Ile Lys Glu Lys Phe Gly Asn Lys Arg Thr Asp Asp 
    770                 775                 780                 


Asn Thr Ile Arg Phe Leu Lys Lys Ala Ala Lys Arg Ile Arg Glu Asn 
785                 790                 795                 800 


Glu Ser Glu Ile Leu Val Arg Gln Met Asp Asp Cys Ala Leu Phe Leu 
                805                 810                 815     


Met Val Asn Asp Leu Leu Glu Gly Gly Lys Phe Asn Asp Glu Asp Ile 
            820                 825                 830         


Glu Asn Ile Gly Tyr Asn Lys His His Asn Leu Leu Asp His Glu Tyr 
        835                 840                 845             


Asp Met Cys Glu Thr Ile Tyr Gly Arg Lys Val Thr Ala Arg Leu Pro 
    850                 855                 860                 


Ile Lys Arg Tyr Gly Glu Phe Arg Arg Phe Met Lys Asp Arg Arg Leu 
865                 870                 875                 880 


Gln Asn Leu Val Lys Tyr Tyr Pro Gly Asp His Glu Thr Pro Ile Pro 
                885                 890                 895     


Ser Gly Ile Pro Glu Ser Gly Lys Ala Met Glu Lys Asn Lys Lys Tyr 
            900                 905                 910         


Thr Tyr Ser Asn Leu Cys Asp Glu Leu Glu Ile Tyr Asp Lys Glu Arg 
        915                 920                 925             


Asp Asn Val Leu Asn Leu Ile Tyr Glu Val Asp Lys Ile Leu Val Asp 
    930                 935                 940                 


His Phe Pro Asp Lys Ile Met Lys Glu Glu Asp Gly Tyr Tyr Glu His 
945                 950                 955                 960 


Tyr His Cys Leu Asp Phe Ala Lys Lys Glu Phe Gly Leu Glu Ser Asp 
                965                 970                 975     


Val Glu Leu Leu Ser Gln Asp Asn Phe Lys Asp Leu Arg Asn Ala Leu 
            980                 985                 990         


Tyr His Asn Gln Ile Pro Tyr Asn  Asp Trp Val Ala Asp  Lys Ile Ser 
        995                 1000                 1005             


Lys Asp  Thr Glu Glu Pro Met  Tyr Val Arg Arg Ile  Phe Ser Phe 
    1010                 1015                 1020             


Ile Arg  Thr Val Tyr Ser Arg  Leu Leu Asp Gln Ile  Lys Ile Lys 
    1025                 1030                 1035             


Ile Glu  Lys Asp Glu Tyr Lys  Cys Lys 
    1040                 1045         


<210>  2590
<211>  1042
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2590

Met Glu Asn Thr Ala Thr Ile Thr Lys Ala Pro Gly Ile Ala Tyr Asp 
1               5                   10                  15      


Ile Asp Asn Pro Ala His Lys Phe Tyr Phe Gly His Tyr Leu Asn Asn 
            20                  25                  30          


Ala Arg His Asn Leu Phe Lys Ile Phe Asn His Leu Leu His Gly Tyr 
        35                  40                  45              


Gly Gln Pro Thr Val Gly Glu Asn Lys Leu Ala Asp Cys Ile Leu Leu 
    50                  55                  60                  


Ser Pro Val Lys Phe Gln Ser Phe Thr Ser Pro Ala Ala Leu Tyr Glu 
65                  70                  75                  80  


Tyr Met Lys Gln Tyr Leu Pro Val Ile Glu Tyr Leu Lys Glu Thr Asn 
                85                  90                  95      


Lys Glu Glu Gln Val Phe Gly Thr Leu Arg Arg Leu Leu Leu Asp Leu 
            100                 105                 110         


Asn Thr Phe Arg Asn Tyr Phe Ser His His His Tyr Thr Ala Pro Leu 
        115                 120                 125             


Ala Phe Asn Asn Phe Lys Glu Ser Gly Lys Phe Lys Lys Ser Met Pro 
    130                 135                 140                 


Tyr Leu Phe Gly Ser Ala Val Ala Ala Ala Arg Lys Lys Thr Arg Leu 
145                 150                 155                 160 


Pro His Asp Ala Phe Glu Glu Ile Phe Lys Trp Lys Thr Ser Glu Lys 
                165                 170                 175     


His Gly His Val Leu Glu Pro Ser Trp Gln Gln Glu Met Met Lys His 
            180                 185                 190         


Ala Ser Ser Ile Pro Thr Val Phe Gly Leu Val Phe Phe Thr Cys Leu 
        195                 200                 205             


Phe Leu Glu Ala Lys Asp Ala Gly Leu Phe Ile Ser Arg Ile Lys Gly 
    210                 215                 220                 


Leu Lys Asn Ala Thr Glu Asp Lys Phe Lys Ala Asn Arg Glu Ala Phe 
225                 230                 235                 240 


Leu Ala Phe Thr Ile Thr Leu Pro Lys Pro Pro Lys Leu Glu Ser Ser 
                245                 250                 255     


Asp Ile Lys Leu Asp Ile Ile Asn Glu Leu Phe Arg Val Pro Arg Ser 
            260                 265                 270         


Val Tyr Lys Thr Trp Glu Pro Glu Gln Gln Arg Ala Phe Ile Ile Thr 
        275                 280                 285             


Asn Glu Glu Thr Gln Gln Gln Ser Ile Met Lys Arg Tyr Lys Asn Arg 
    290                 295                 300                 


Phe Asp Tyr Phe Ala Leu Arg Tyr Phe Glu Asp Asn Ala Ala Leu Ser 
305                 310                 315                 320 


Asn Ile Phe Phe His Ile Lys Leu Gly Glu Ala Tyr Leu Ala Glu Tyr 
                325                 330                 335     


Glu Lys Pro Lys Pro Gly Asp Asp Ile Lys Thr Asn Arg Leu Val Thr 
            340                 345                 350         


Lys Gln Leu Asn Thr Phe Gly Pro Leu Gln Phe Phe His Asn Lys Lys 
        355                 360                 365             


Asn Leu Ser Asn Leu Gly Tyr Asp Ile Ser Asp Leu Ile Thr Gly Gln 
    370                 375                 380                 


Met Ile Lys Ile Asn Gly Met Ser Val Lys Tyr Met Pro Gln Tyr Arg 
385                 390                 395                 400 


Met Thr Asp Asn Lys Ile Gly Leu Lys Val Val Asn Gln Ser Ala Ala 
                405                 410                 415     


Pro Val Ile Pro Gln Val Gly Lys Ser Asp Arg Pro Leu Asn Asp Ile 
            420                 425                 430         


Tyr Pro Tyr Ala Phe Thr Asn Leu Ser Pro Asp Ile Ile Leu Ser Thr 
        435                 440                 445             


Tyr Glu Leu Pro Asn Leu Tyr Leu Tyr Asn Tyr Phe His Arg Leu Gly 
    450                 455                 460                 


Phe Ile Lys Thr Ala Pro His Glu Phe Leu Glu Thr Cys Leu Lys Gln 
465                 470                 475                 480 


Gln Glu Val Leu Phe Thr Ser Leu Lys Asn Gln Glu Ala Ser Thr Met 
                485                 490                 495     


Asn Asp Ala Gly Tyr Lys Lys Thr Lys Leu Pro Val Lys Ile Arg Lys 
            500                 505                 510         


His Ile Thr Gly Ser Thr Ser Ile Ala Glu Glu Val Arg Lys Lys Leu 
        515                 520                 525             


Arg Ser Leu Leu Asn Asp Thr Asn Glu Thr Leu Asp Arg Leu Ala Glu 
    530                 535                 540                 


Gln Gly Lys Leu Glu Lys Gly Lys Gly Lys Thr Gly Phe Thr Ala Gly 
545                 550                 555                 560 


Ser Val Ala Thr Trp Ile Ala Thr Asp Ile Gln Phe Phe Ser Arg Pro 
                565                 570                 575     


Asp Asp Lys Lys Gln Lys Leu Ser Asp Phe Glu Tyr Arg Ser Leu Gln 
            580                 585                 590         


Glu Tyr Ile Ala Phe Phe Gly Ser Asn Arg Asn Lys Ile Asp Ala Leu 
        595                 600                 605             


Leu Lys Ser Phe Gln Ile Thr Gly Thr Asp Asn Asn Arg His Pro Phe 
    610                 615                 620                 


Leu Lys Thr Val Gln Gly Met Ile Asp Glu Phe Thr Ala Arg Val Lys 
625                 630                 635                 640 


Glu Arg Gln Lys Lys Gly Arg Gly Pro Lys Arg Asn Phe Asp Thr Ala 
                645                 650                 655     


Ile Tyr Ser Leu Ser Thr Phe Phe Lys Asp Tyr Leu Phe Glu Arg Arg 
            660                 665                 670         


Arg Tyr Ile Glu Asp Leu Leu Lys Asn Ile Asn Asp Asn Met Ile Asp 
        675                 680                 685             


Asn Ile Ser Tyr Phe Thr Lys Ile Lys Arg Asn Ala Gln Ala Glu Leu 
    690                 695                 700                 


Asp Tyr His Glu Pro Val Met Leu Pro Arg Asn Ile Phe Asn Lys Ser 
705                 710                 715                 720 


Ile Val Val Gly Leu Lys Asp Phe Met Gln Ser Lys Asn Ile Pro Phe 
                725                 730                 735     


Ser Thr Gly Asp Val Lys Lys Cys Ser Pro Ser Phe Phe Leu Lys Gln 
            740                 745                 750         


Leu Met Pro Lys Leu Gln Glu Phe Tyr Asp Leu Arg Arg Thr Tyr Lys 
        755                 760                 765             


Lys Tyr Asp Val Val Glu Gly Glu Tyr Glu Phe Val Glu Asp Ile Val 
    770                 775                 780                 


Ile Asp Lys Asp Asn Asp Leu Arg Lys Cys Gln Ile Lys Leu Lys Ala 
785                 790                 795                 800 


Asp Gly Glu Ala Tyr Thr Glu Leu Leu Asn Arg Ile Asp Asn Asn Glu 
                805                 810                 815     


Leu Asp Ile Arg Leu Glu Gln Tyr Arg Asp Arg Val Leu Phe Met Met 
            820                 825                 830         


Leu Gln Glu Tyr Phe Asn Asn Gln Gly Ile Glu Glu Leu Asp Phe Ser 
        835                 840                 845             


Asp Lys Thr Leu Lys Asp Phe Ser Lys Asp Phe Arg Asp Asn Thr Thr 
    850                 855                 860                 


Lys Thr Ile Leu Asp Thr Glu Ile Asp Met Ser Ile Arg Leu Asn Asp 
865                 870                 875                 880 


Val Asp Ile Lys Ala Arg Leu Pro Ile Gly Arg Tyr Gly Glu Phe Arg 
                885                 890                 895     


Lys Ile Leu Arg Asp Arg Arg Ile Asn Glu Leu Leu Gly Tyr Phe Glu 
            900                 905                 910         


Ile Glu Val Ala Trp Asn Thr Leu Gln Glu Glu Leu Glu Tyr Tyr Asn 
        915                 920                 925             


Gln Asn Arg Glu Lys Val Leu Lys Ala Cys Ile Glu Phe Glu Glu Ala 
    930                 935                 940                 


Val Tyr Ala Lys His Gly Ser Lys Met Asn His Leu Val Lys Asp Asn 
945                 950                 955                 960 


His Ile Ser His Tyr Asn Phe Leu Gln Tyr Tyr His Phe Ser Val Lys 
                965                 970                 975     


Lys Leu Asn Asp Asp Tyr Leu Gly Lys Asp Gly Glu Ile Lys Val Ala 
            980                 985                 990         


Glu Leu Arg Asn Arg Phe Leu His  Asn Gln Ile Ile Asp  Lys Gln Phe 
        995                 1000                 1005             


Phe Thr  Glu Val Phe Arg Asp  Val Glu Phe Asn Ser  Ser Leu Ile 
    1010                 1015                 1020             


Thr Lys  Gln Ile Ile Asp Ser  Val Thr Asp Val Tyr  Ser Gln Leu 
    1025                 1030                 1035             


Lys Ser  Ser Val 
    1040         


<210>  2591
<211>  1131
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2591

Met Glu Lys Thr Ile Glu Asn Gln Thr Gln Ser Lys Arg Thr Leu Asn 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Asp Glu Glu Lys Ile Thr Thr Ser Phe Leu Val Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Arg Gln Ser Leu Val Tyr Ser Asn Leu Thr 
65                  70                  75                  80  


Arg Tyr Met His Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Asp 
                85                  90                  95      


Asp Glu Arg Asp Lys Ala Glu Asn Tyr Gly Lys Asp Phe Gly Asn Leu 
            100                 105                 110         


Thr Asp Thr Leu Lys Glu Ile Phe Lys Glu Leu Asn Glu Phe Arg Asn 
        115                 120                 125             


Asp Tyr Ser His Tyr Tyr Ser Thr Glu Lys Lys Asp Lys Arg Lys Thr 
    130                 135                 140                 


Ile Val Ser Asp Lys Leu Lys Asn Phe Leu Asn Ile Asn Tyr Thr Arg 
145                 150                 155                 160 


Ala Ile Lys Tyr Thr Lys Ser Arg Phe Ile Asn Val Phe Ser Asp Asn 
                165                 170                 175     


Asn Phe Cys Leu Ala Glu Glu Ala Lys His Val Glu Asn Asp Asn Thr 
            180                 185                 190         


Ile Thr Gln Asp Gly Ile Val Phe Phe Thr Ser Met Phe Leu Asp Arg 
        195                 200                 205             


Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile Ile Gly Leu Lys Gly Thr 
    210                 215                 220                 


Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Thr Leu Met Ala Phe Cys 
225                 230                 235                 240 


Val Asn Leu Pro His Asp Lys Phe Val Ser Glu Asn Ser Glu Gln Gln 
                245                 250                 255     


Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu 
            260                 265                 270         


Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln His Phe Leu Pro Lys Leu 
        275                 280                 285             


Asp Asp Glu Gln Ile Asp Asn Val Leu Glu Asn Ser Val Pro Tyr Thr 
    290                 295                 300                 


Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn Ile Thr Lys Lys Val Arg 
305                 310                 315                 320 


Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu Lys Phe Ile Asp Gln Lys 
                325                 330                 335     


Lys Leu Phe Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val 
            340                 345                 350         


Leu Asp Glu Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Lys Arg Thr 
        355                 360                 365             


Val Thr Glu Asn Thr Lys Ala Phe Gly Met Leu Gln Asp Leu Asn Asp 
    370                 375                 380                 


Glu Glu Asn Val Leu Asn Lys Ile Asn Thr Gly Glu Ser Lys Ala Lys 
385                 390                 395                 400 


Phe Asp Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Thr Lys Asn 
            420                 425                 430         


Thr Asp Asn Lys Ile Lys Ser Asn Leu Leu Gln Pro Leu Pro Glu Ala 
        435                 440                 445             


Phe Leu Ser Ile Asn Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
    450                 455                 460                 


Glu Gln Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn 
465                 470                 475                 480 


Asn Ser Lys Ile Leu Asn Lys Glu Phe Ile Lys Ala Ile Lys Leu Lys 
                485                 490                 495     


Leu Asn Asp Leu Asp Val Phe Tyr Lys Arg Ser Gln Gly Arg Lys Gln 
            500                 505                 510         


Lys His Ala Tyr Leu Thr Lys Asp Lys Lys Tyr Asp Asn Glu Lys Ile 
        515                 520                 525             


Asn Glu Leu Lys Asn Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu 
    530                 535                 540                 


Tyr Asn Leu Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp 
545                 550                 555                 560 


Leu Asn Ile Ala Asp Val Gln Ala Lys Asn Ala Ile Ser Asp Arg Ile 
                565                 570                 575     


Lys Leu Met Lys Arg Asp Cys Ile Asn Arg Leu Lys Ser Met Lys Lys 
            580                 585                 590         


Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp 
        595                 600                 605             


Ile Val Asp Met Ile Ile Asp Glu Glu Lys Lys Lys Lys Ile Thr Ser 
    610                 615                 620                 


Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Lys 
625                 630                 635                 640 


Glu Lys Lys Glu Leu Phe Ile Leu Ile Cys Asn Asn Glu Leu Lys Leu 
                645                 650                 655     


Asn Asp Asp Asp Gly His Pro Phe Phe Lys Asn Ile Asn Phe Ser Asn 
            660                 665                 670         


Tyr Lys Tyr Thr Ser Glu Ile Tyr Gln Lys Tyr Leu Glu Glu Lys Gly 
        675                 680                 685             


His Lys Met Val Lys Glu Tyr Asn Pro Arg Lys Glu Asn Tyr Val Glu 
    690                 695                 700                 


Lys Asp Lys Ser Trp Leu Glu Ile Asn Phe Tyr Lys Lys Glu Trp Asn 
705                 710                 715                 720 


Glu Asn Ala Lys Lys Asp Leu Thr Val Val Lys Leu Pro Asp Asp Lys 
                725                 730                 735     


Ser Lys Ile Pro Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser 
            740                 745                 750         


Phe Glu Asn Trp Phe Lys Tyr Val Thr Asn Gly Lys Glu Thr Thr Asp 
        755                 760                 765             


Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp Glu Thr Leu 
    770                 775                 780                 


Lys Glu Leu Leu Lys Lys Glu Leu Ser Lys Asn Asn Ile Glu Phe Lys 
785                 790                 795                 800 


Glu Glu Asp Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Asp Lys Cys 
                805                 810                 815     


Arg Asn Asp Lys Thr Gln Lys Phe Tyr Ser Ala Glu Arg Glu Tyr Thr 
            820                 825                 830         


Phe Glu Glu Glu Lys Leu Asn Phe His Ile Asn Thr Lys Ser Lys Phe 
        835                 840                 845             


Glu Glu Tyr Ile Asn Pro Glu Phe Ala Glu Lys Val Phe Arg Leu Lys 
    850                 855                 860                 


Asn Gln Asn Arg Glu Lys Asp Asn Ile Ser Gly Arg Arg Leu Pro Pro 
865                 870                 875                 880 


Leu Lys Met Lys Glu Val Thr Lys Asn Met Val Lys Arg Ile Gly Asn 
                885                 890                 895     


Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Leu Met Leu 
            900                 905                 910         


Leu Met Phe Glu Lys Leu Val Asp Asn Asn Leu Lys Leu Lys Leu Glu 
        915                 920                 925             


Asn Val Asp Lys Leu Leu Asn Glu Ser Ile Glu Ile Asn Gln Ser Ile 
    930                 935                 940                 


Ser Gly Lys Leu Ser Phe Asn Asp Ser Gly Asp Asn Glu Asn Lys Lys 
945                 950                 955                 960 


Asp Arg Ala Ile Ile Cys Arg Asn Ile Thr Glu Thr Arg Lys Arg Lys 
                965                 970                 975     


Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Glu Glu Glu  Asn Ile Pro Ile Glu  Lys Ile Lys 
        995                 1000                 1005             


Ile Glu  Leu Asp Thr Tyr Ser  Lys Ala Lys Asp Val  Val Phe Asp 
    1010                 1015                 1020             


Leu Ile  Phe Asp Leu Glu Arg  Ala Ile Ile Asn Lys  Asp Glu Asn 
    1025                 1030                 1035             


Arg Ile  Lys Glu Leu Asn Lys  Asp Lys Asn Gly Val  Ile Gln Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Phe Trp Leu  Leu Glu Lys 
    1055                 1060                 1065             


Asn Leu  Ile Thr Glu Gln Glu  Phe Thr Phe Met Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Thr  Phe Ser His Asn Gln  Phe Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Leu Phe  Ile Lys Asn Trp Asn  Glu Asn Glu Phe Ala  Lys Gln Ile 
    1100                 1105                 1110             


Leu Asn  Val Tyr Asn Gln Lys  Asn Asn Asn Leu Ile  Lys Ser Ile 
    1115                 1120                 1125             


Lys Asp  Ile 
    1130     


<210>  2592
<211>  1194
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2592

Met Glu Asn Thr Phe Ala Ala Phe Leu Arg His Phe Asp Asn Ala Gly 
1               5                   10                  15      


Ile Val Gly Pro Ile Ser Glu Lys Ala Val Lys Asn Ile Glu Leu Lys 
            20                  25                  30          


Arg Ser Asn Lys Ile Asn Arg Met Gln Arg Ile His Tyr Phe Ala Ile 
        35                  40                  45              


Gly His Thr Phe Lys Gln Ile Asp Thr Lys Thr Val Phe Gln Tyr Glu 
    50                  55                  60                  


Phe Ser Glu Asp Asp Lys Asp Glu Val Pro Thr Lys Phe Leu Ser Leu 
65                  70                  75                  80  


Gln Ser Tyr Asn Phe Leu Phe Glu Glu Lys Leu Phe Ser Leu Ile Lys 
                85                  90                  95      


Ser Ile Arg Asn Leu Asn Ser His Tyr Ala His Thr Phe Asp Ser Leu 
            100                 105                 110         


Glu Val Glu Asn Thr Ile Gly Ser Lys Leu Ile Asn Phe Leu Lys Glu 
        115                 120                 125             


Ser Phe Glu Leu Ala Ser Leu Gln Thr Tyr Leu Lys Glu Lys Gly Asn 
    130                 135                 140                 


Leu Pro Ile Asp Asp Phe Glu Leu Thr Asn Phe Leu Lys Arg Met Phe 
145                 150                 155                 160 


Ile Pro Lys Lys Lys Gly Arg Asp Lys Asp Asn Asn Glu Arg Lys Gln 
                165                 170                 175     


Lys Asn Lys Asn Trp Asn Leu Tyr Val Asp Ser Leu Lys Thr Lys Glu 
            180                 185                 190         


Gln Val Ile Asp Ala Ile Leu Phe Ile Ser Val Asp Asn Glu Phe Phe 
        195                 200                 205             


Trp Lys Ile Asn Asn Glu Val Glu Val Leu Lys Ile Thr Glu Gly Thr 
    210                 215                 220                 


Tyr Leu Ser Phe Glu Ala Cys Leu Phe Leu Ile Ser Met Phe Leu Tyr 
225                 230                 235                 240 


Arg Asn Glu Ala Asn Ser Leu Ile Ser Lys Ile Gln Gly Tyr Lys Lys 
                245                 250                 255     


Ser Asn Asn Asp Lys Met Arg Ser Lys Arg Glu Leu Ile Ser Phe Phe 
            260                 265                 270         


Ser Lys Lys Phe Ser Ser Gln Asp Val Asp Ser Asn Glu Thr His Leu 
        275                 280                 285             


Val Lys Phe Arg Asp Ile Ile Gln Tyr Leu Asn His Tyr Pro Ile Thr 
    290                 295                 300                 


Trp Asn Lys Asp Leu Lys Leu Gln Ser Glu Asn Asp Asn Pro Lys Met 
305                 310                 315                 320 


Thr Lys Val Leu Ile Asp Arg Ile Ile Ser Met Glu Ile Tyr Arg Ala 
                325                 330                 335     


Phe Pro Asp Tyr Ala Asp Asn Ile Gly Phe Ser Glu Phe Val Lys Lys 
            340                 345                 350         


Tyr Leu Phe Ser Asn Ser Lys Lys Ile Gln Ile Asn Tyr Val Met Asn 
        355                 360                 365             


Lys Leu Ser Asp Ile Glu Arg Glu Tyr Tyr Glu Val Val Thr Gln Asp 
    370                 375                 380                 


Pro His Ile Lys Ile Phe Lys Lys Asp Ile Glu Gln Ala Val Lys Pro 
385                 390                 395                 400 


Ile Ser Tyr Asn Arg Lys Glu Asp Ala Phe Lys Ile Phe Val Lys Gln 
                405                 410                 415     


Tyr Val Leu Lys Thr Tyr Phe Pro Lys Ile Lys Gly Phe Glu Lys Phe 
            420                 425                 430         


Thr Ser His Lys Phe Lys Tyr Asn Arg Arg Thr Gly Lys Thr Glu Asp 
        435                 440                 445             


Val Glu Asn Asp Phe Gln Ser Lys Leu Phe Thr Asn Leu Glu Thr Gly 
    450                 455                 460                 


Lys Leu Lys Arg Arg Ile Ile His Lys Ser Leu Phe Lys Ser Tyr Gly 
465                 470                 475                 480 


Arg Asn Gln Asp Arg Phe Met Asn Phe Ala Met Arg Phe Leu Ala Gln 
                485                 490                 495     


Arg Asn Tyr Phe Gly Lys Thr Val Glu Tyr Lys Thr Tyr Gln Phe Tyr 
            500                 505                 510         


Asn Ser Leu Glu Gln Glu Ala Phe Ile Glu Glu Leu Lys Ala Asn Lys 
        515                 520                 525             


Cys Asn Lys Thr Pro Lys Glu Leu Lys Asn Glu Ile Asp Asn Leu Lys 
    530                 535                 540                 


Tyr His Asn Gly Lys Leu Val His Phe Thr Thr Tyr Asp Lys His Cys 
545                 550                 555                 560 


Glu Asn Tyr Pro Glu Trp Asp Ala Pro Phe Val Asn Gln Asn Asn Ala 
                565                 570                 575     


Ile Ser Ile Lys Ile Thr Leu Gly Gln Val Glu Lys Ile Ile Pro Ile 
            580                 585                 590         


Gln Arg Ser Leu Ile Ile Tyr Phe Leu Glu Asp Ala Leu Tyr Ser Asp 
        595                 600                 605             


Asn Pro Asp Gly Lys Gly Leu Ile Thr Asn Tyr Tyr Tyr Asn Ser Tyr 
    610                 615                 620                 


Leu Lys Asp Phe Tyr Lys Tyr Asn Asn Ser Val Ile Asn Asp Lys Ile 
625                 630                 635                 640 


Asn Ala Asp Asp Lys Arg Glu Phe Lys Lys Leu Leu Pro Arg Arg Leu 
                645                 650                 655     


Leu Asn Gln Tyr Val Pro Ala Val Gln Asn Asn Leu Pro Lys His Thr 
            660                 665                 670         


Val Leu Glu Lys Leu Leu Ile Glu Ala Glu Lys Lys Glu Glu Thr Tyr 
        675                 680                 685             


Ser Leu Leu Ile Ala Glu Ala Lys Lys Thr Glu Phe Lys Ile Asn Gln 
    690                 695                 700                 


Ala Tyr Thr Glu Glu Lys Ala Thr Leu Leu Glu Asp Phe Lys Asn Arg 
705                 710                 715                 720 


Asn Lys Gly Lys Arg Phe Lys Leu Gln Phe Ile Arg Lys Ala Cys His 
                725                 730                 735     


Ile Met Tyr Phe Lys Glu Thr Tyr Asp Leu Gln Val Ala Asp Gly Lys 
            740                 745                 750         


His His Lys Arg Phe His Ile Thr Lys Asp Glu Phe Asn Asp Phe Cys 
        755                 760                 765             


Lys Trp Met Tyr Ala Phe Glu Gly Glu Asp Asn Tyr Lys Arg Tyr Leu 
    770                 775                 780                 


Asn Glu Leu Phe Glu Val Lys Gly Phe Tyr Leu Asn Met Asp Phe Lys 
785                 790                 795                 800 


Lys Ile Phe Asn Asp Ser Thr Ser Ile Glu Ser Met Tyr Gln Lys Val 
                805                 810                 815     


Lys Met Ala Tyr Lys Thr Trp Leu Val Asn Asn Asp Val Lys Lys Glu 
            820                 825                 830         


Arg Gln Ile Asn Tyr Ala Ile Glu Lys Val Glu Ile Lys Lys Asp Ile 
        835                 840                 845             


Tyr Lys Lys Val Tyr Lys Ile Asn Thr Asn Met Phe Tyr Ile Asn Val 
    850                 855                 860                 


Ser His Phe Ile Lys Phe Leu Glu Ser Lys Asn Lys Ile Lys Arg Asp 
865                 870                 875                 880 


Ser Lys Asn Arg Leu Ile Tyr Asn Ser Leu Glu Asn Glu Thr Phe Leu 
                885                 890                 895     


Ile Lys Glu Tyr Tyr Tyr Lys Lys Gln Leu Glu Lys Ser Glu Tyr Lys 
            900                 905                 910         


Asp Cys Gly Lys Leu Tyr Asn Lys Leu Lys Lys Asn Lys Leu Glu Asp 
        915                 920                 925             


Ala Leu Leu Phe Glu Ile Ala Leu Asn Tyr Met Val Asn Lys Asp Ile 
    930                 935                 940                 


Ile Ser Lys Asn Asn Val Asn Asp Met Leu Leu Gln Asn Leu Val Phe 
945                 950                 955                 960 


Asp Ile Lys Asn Arg Ile Asp Lys Asp Ser Tyr Lys Ile Thr Val Pro 
                965                 970                 975     


Phe Ser Lys Ile Asp Asn Tyr Leu Glu Phe Val Thr Gln Lys Asn Met 
            980                 985                 990         


Gln Glu Asp Ser Val Tyr Ala Thr  Ser Phe Leu Gly Asp  Leu Gln Glu 
        995                 1000                 1005             


Tyr Leu  Lys Leu Asn Gln Ile  Pro Asn Gly Lys Lys  Gly Asp Lys 
    1010                 1015                 1020             


Ser Ile  Tyr Ile Gly Asp Leu  Gln Phe Ser Asp Leu  Thr Ala Ile 
    1025                 1030                 1035             


Asn Asn  His Ile Ile Lys Glu  Ala Leu Lys Phe Ser  Glu Met Leu 
    1040                 1045                 1050             


Met Ser  Ala Glu Ala Tyr Tyr  Ile His Lys Asp Lys  Met Gln Ile 
    1055                 1060                 1065             


Lys Asp  Asn Ala Tyr Asn Ile  Asp Ser Lys Asp Ile  Pro Ser Leu 
    1070                 1075                 1080             


Gln Val  Ile Ala Lys Ala Trp  Arg Ile Trp Gly Ser  Glu Gln Glu 
    1085                 1090                 1095             


Glu Asp  Asp Lys Pro Glu Ile  Asp Phe Arg Asn Leu  Val Cys His 
    1100                 1105                 1110             


Phe Asn  Leu Pro Leu Lys Lys  Lys Leu Val Asp Ile  Met His Asp 
    1115                 1120                 1125             


Ala Glu  Gln Arg Phe Val Lys  Ala Glu Ile Ser Lys  Asn Ile Thr 
    1130                 1135                 1140             


Asp Phe  Glu Gln Leu Ser Asp  Thr Gln Lys Asn Ile  Cys Gln Val 
    1145                 1150                 1155             


Phe Ile  Ala Asn Leu His Asn  Ala Ile Cys Tyr Pro  Asn Tyr Lys 
    1160                 1165                 1170             


Gln Gly  Lys Asp Lys His Ala  Asn Ala Lys Lys Ile  Tyr Phe Asn 
    1175                 1180                 1185             


Lys Ile  Ile Lys Ala Asn 
    1190                 


<210>  2593
<211>  1049
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2593

Met Asp Ile Ser Asn Glu Lys Thr Ser Arg Tyr Lys Asp Leu Glu Asn 
1               5                   10                  15      


Asp Pro Tyr Tyr Phe Asn His Phe Ile Asn Met Gly Arg His Asn Ala 
            20                  25                  30          


Tyr Leu Ile Leu His Asp Val Tyr Lys Thr Val Tyr Lys Glu Glu Leu 
        35                  40                  45              


Ser Leu Glu Glu Asn Asn Leu Ala Val Phe Arg Lys Lys Val Leu Glu 
    50                  55                  60                  


Lys Ser Gln Asn Lys Pro Asp Glu Ile Ala Lys Val Val Asn Met Leu 
65                  70                  75                  80  


Leu Arg His Phe Pro Phe Leu Ala Tyr Tyr Glu Glu Arg Gln Gln Tyr 
                85                  90                  95      


Val Lys Glu Lys His Glu Tyr Glu Ser Leu Asn Arg Leu Ala Asp Tyr 
            100                 105                 110         


Leu Gly Ala Leu Asn Lys Ile Arg Asn Gln Thr Ser His Tyr Lys His 
        115                 120                 125             


Asn Lys Glu Asp Ile Tyr Leu Pro Asp Tyr Gln Gly Leu Phe Gln Met 
    130                 135                 140                 


Ser Val Lys Glu Ala Gln Asn Arg Met Lys Tyr Glu Asp Lys Asp Val 
145                 150                 155                 160 


Lys His Leu Tyr Arg Thr Gln Tyr Tyr Asn Leu Val Asn Asn Asn Ile 
                165                 170                 175     


Leu Thr Glu Ala Gly Ile Ser Tyr Phe Val Cys Leu Phe Leu Asp Lys 
            180                 185                 190         


Lys Asn Gly Tyr Leu Phe Leu Ser Arg Ile Lys Gly Phe Lys Asp Arg 
        195                 200                 205             


Asn Lys Thr Ser Glu Arg Tyr Lys Ser Ala Thr Leu Glu Ala Phe Thr 
    210                 215                 220                 


Gln Phe His Ser His Val Pro Tyr Pro Lys Leu Asp Ser Ser Asp Ile 
225                 230                 235                 240 


Ala Leu Asp Met Leu Asn Glu Leu Asn Arg Cys Pro Lys Gln Leu Tyr 
                245                 250                 255     


Asn Val Leu Ser Ala Glu Asp Gln Asn Lys Phe Ile Ala Thr Leu Ser 
            260                 265                 270         


Glu Asp Gly Asp Asp Glu Leu Pro Lys Pro Leu Met Lys Arg Ser Glu 
        275                 280                 285             


Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Glu Lys Ser Gly Lys 
    290                 295                 300                 


Leu Asp Asn Ile Thr Phe Gln Leu Tyr Leu Gly Arg Lys His Ala Gln 
305                 310                 315                 320 


Glu Pro His Thr Lys Lys Ile Ala Gly Val Glu Arg Thr His Phe Leu 
                325                 330                 335     


Leu Lys Asn Met His Val Phe Gly Lys Leu Pro Phe Tyr Lys Glu Glu 
            340                 345                 350         


Glu Ala His Arg Phe Tyr Gly Glu Asn Glu Glu Val Glu Phe Tyr Ala 
        355                 360                 365             


Pro Ala Phe Arg Met Val Gly Asn Arg Ile Gly Leu Val Leu Arg Glu 
    370                 375                 380                 


Glu Leu Gln Ser His Tyr Thr Val Pro Ala Thr Asn Lys Thr Glu Lys 
385                 390                 395                 400 


Asp Lys Asn Tyr Pro Asp Ala Ile Leu Ser Thr Arg Glu Leu Ser Gly 
                405                 410                 415     


Leu Phe Phe Tyr Asn Phe Leu Tyr Lys Lys Gly Trp Ile Glu Asp Ser 
            420                 425                 430         


Pro Gln Lys Phe Ile Arg Asn Tyr Leu Leu Glu Phe Arg Arg Phe Ile 
        435                 440                 445             


Asn Asp Leu Gln Glu Lys Lys Ile Val Pro Ile Ser Thr Thr Ser Phe 
    450                 455                 460                 


Ile Gly Lys Arg Lys Arg His Lys Asp Glu Asp Leu Arg Ile Leu Asn 
465                 470                 475                 480 


Glu Arg Ser Asn Lys Leu Gln Ala Leu Leu Asp Glu Tyr Gly Leu Lys 
                485                 490                 495     


Ile Asp Trp Ile Pro Asp Asp Cys Arg Glu Tyr Leu Leu Asn Tyr Arg 
            500                 505                 510         


Val Ser Ser Asp Ala Tyr Ile Ile Lys Glu Lys Phe Val Val Met Arg 
        515                 520                 525             


Lys Asn Ala Asn Ser Lys Leu Ala Arg Met Lys Ala Phe Ser Glu Val 
    530                 535                 540                 


Glu Ser Glu Ala Glu Lys Glu Gly Val Arg Thr Met Ser Val Ala Arg 
545                 550                 555                 560 


Lys Gln Leu Arg Ile Gly Glu Leu Ala Gln Glu Leu Ala Arg Asp Ile 
                565                 570                 575     


Val Phe Leu Thr Pro Pro Gln Glu Ile Cys Gly Gly Glu Lys Lys Lys 
            580                 585                 590         


Ile Asn Asn Met Glu Phe Asp Val Leu Gln Lys Met Leu Ala Tyr Phe 
        595                 600                 605             


Pro Val Tyr Lys Asp Glu Leu Lys Thr Tyr Phe Asp Val Leu Lys Glu 
    610                 615                 620                 


Lys Asp Lys Lys Trp Lys His Pro Phe Leu His Trp Val Val Thr Ser 
625                 630                 635                 640 


Arg Tyr Thr Ser Tyr Ser Ser Leu Ile Lys Met Tyr Glu Ala Tyr Tyr 
                645                 650                 655     


Gln Ser Lys Ile Lys Trp Ile Asp Lys Glu Ile Leu Asp Gly Ile Arg 
            660                 665                 670         


Gly Thr Glu Gly Tyr Ile Thr Gly Trp Arg Leu Lys Asp Ile Asp Ala 
        675                 680                 685             


Val Val Ser Lys Tyr Glu Tyr Ile Leu Lys Leu Lys Gln Lys Thr Lys 
    690                 695                 700                 


Leu Ala Ile Asp Lys Glu Tyr Leu Asp Lys Ala Val Tyr Leu Pro Thr 
705                 710                 715                 720 


Asp Leu Phe Lys Cys Ala Ile Val Lys Thr Met Arg Gly His Gly Tyr 
                725                 730                 735     


Thr Leu Lys Glu Gly Ser Ser Val Ala Gly Cys Leu Met Ile Tyr Leu 
            740                 745                 750         


Lys Asn Lys Lys Gln Pro Met Tyr Gly Leu Pro Arg Tyr Tyr Gln Ala 
        755                 760                 765             


Lys Asp Leu Gly Phe Gly Gln Glu Lys Ser Arg Asp Glu Ile Lys Glu 
    770                 775                 780                 


His Ile Lys Asn Lys Phe Glu Ser Val Asp Ala Glu Val Gln Arg Asp 
785                 790                 795                 800 


Met Lys Ile Val Ala Lys Arg Ile Arg Glu Asn Glu Thr Glu Ile Leu 
                805                 810                 815     


Arg Gln Gln Ala Asn Asp Arg Thr Leu Phe Leu Met Val Asn Asp Leu 
            820                 825                 830         


Leu Pro Ala Ser Phe Glu Glu Asp Asp Ile Glu Arg Leu Gly Phe Asn 
        835                 840                 845             


Gln Gln Asp Asn Ile Leu Glu Ser Glu Tyr Asp Met Ser Glu Arg Ile 
    850                 855                 860                 


Tyr Gly Arg Lys Val Thr Thr Arg Leu Pro Ile Lys Arg Tyr Gly Glu 
865                 870                 875                 880 


Phe Arg Arg Phe Leu Lys Asp Arg Arg Leu Glu Asn Leu Leu Lys Tyr 
                885                 890                 895     


Tyr Pro Glu Glu Ser Asp Ile Ala Leu Gly Ile Ile Glu Ser Gly Lys 
            900                 905                 910         


Thr Gln Gln Arg Gly Glu Lys Phe Met Tyr Ser Asn Leu Ala Glu Glu 
        915                 920                 925             


Leu Glu Leu Tyr Asp Met Glu Arg Asp His Leu Leu Glu Leu Met Tyr 
    930                 935                 940                 


Lys Val Asp Lys Thr Leu Val Asp Asn Phe Ser Glu Ile Pro Lys Lys 
945                 950                 955                 960 


Asn Asn Lys Tyr Tyr Glu His Tyr Asp Cys Leu Glu Tyr Ala Lys Asn 
                965                 970                 975     


Ser Leu Gly Leu Thr Glu Asp Val Glu Leu Leu Glu Lys Glu Thr Phe 
            980                 985                 990         


Lys Thr Leu Arg Asn Ser Met Leu  His Asn Gln Ile Pro  Tyr Glu Glu 
        995                 1000                 1005             


Trp Ile  Lys Glu Glu Ile Asp  Lys Met Glu Gly Glu  Pro Met Ile 
    1010                 1015                 1020             


Thr Lys  Arg Ile Ile Thr Leu  Ile Gly Asp Val Tyr  Asn Arg Leu 
    1025                 1030                 1035             


Leu Ser  Gly Ile Glu Leu Lys  Ile Ser Asn Ser 
    1040                 1045                 


<210>  2594
<211>  1024
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2594

Met Pro Tyr Tyr His Ser Thr Ile Asp Lys Ala Leu Phe Gly Ala Tyr 
1               5                   10                  15      


Leu Asn Met Ala Arg Asn Asn Leu Arg Met Val Leu Thr Asn Ile Glu 
            20                  25                  30          


Glu Lys Val Tyr Gly Lys Ser Gly Asn Trp Lys Glu Asp Ser Met Arg 
        35                  40                  45              


His Ser Ser Val Ile Lys Ala Leu Glu Lys Asn Glu Gln Pro Asp Val 
    50                  55                  60                  


Ser Lys Arg Ile Thr Asp Met Leu Leu Arg Asp Leu Pro Phe Leu Lys 
65                  70                  75                  80  


Leu Thr Val Lys Ser Lys Leu Asn Pro Ser Ala Asn Asp Tyr Ala Thr 
                85                  90                  95      


Ser Leu Ile Glu Phe Ile Glu Gln Leu Ser Gln Leu Arg Asn Phe His 
            100                 105                 110         


Cys His Tyr Leu His Asn Pro Tyr Lys Thr Asn Pro Glu Ile Ile Glu 
        115                 120                 125             


Ser Leu Arg His Ile Phe Asp Ala Ala Arg Arg Arg Val Lys Ile Arg 
    130                 135                 140                 


Phe Asn Tyr Thr Thr Glu Glu Val Glu His Leu Val Arg Lys Ile Ala 
145                 150                 155                 160 


Gly Met Val Asn Gly Lys Arg Val Gly Ile Glu Lys Lys Asn Tyr Ser 
                165                 170                 175     


Phe Ala Phe Ala Asp Ala His Glu Glu Ile Thr Glu Ile Gly Ile Ala 
            180                 185                 190         


Phe Phe Thr Cys Leu Phe Leu Asn Lys Lys Tyr Ile Thr Leu Phe Leu 
        195                 200                 205             


Lys Gln Leu Lys Gly Phe Lys Asp Ser Arg Thr Arg Lys Thr Arg Ala 
    210                 215                 220                 


Thr Ile Asn Thr Phe Gly Phe Phe Asn Ile Arg Ile Pro Gln Pro Lys 
225                 230                 235                 240 


Leu Gln Ser Asn Asp Thr Lys Glu Gly Leu Leu Met Asp Ile Leu Glu 
                245                 250                 255     


Asp Leu Lys Arg Cys Pro Asn Glu Leu Phe Glu His Leu Ser Ala Glu 
            260                 265                 270         


Asp Gln Glu Arg Phe Arg Val Lys Ser Asp Asn Gln Glu Glu Glu Asn 
        275                 280                 285             


Glu Val Leu Gln Lys Arg Phe Ser Asp Arg Phe Pro Tyr Leu Ala Leu 
    290                 295                 300                 


Arg Tyr Phe Glu Leu Thr Glu His Val Lys Asp Phe Gln Phe His Thr 
305                 310                 315                 320 


Asp Leu Gly Lys Tyr Asn Phe Lys His Tyr Lys Lys Gln Val Gly Gly 
                325                 330                 335     


Glu Glu Arg Ile Arg Gln Leu Gln Lys Asn Met Lys Gly Thr Gly Arg 
            340                 345                 350         


Leu Lys Asp Phe Thr Glu Asp Lys Met Pro Glu Glu Trp Asn Val Leu 
        355                 360                 365             


Val Lys Arg Ser Asp Glu Leu Pro Gly Asp Tyr Met Glu Pro His Ile 
    370                 375                 380                 


Val Phe Thr Asn Pro His Tyr His Phe Val Asn Asn Gln Ile Gly Val 
385                 390                 395                 400 


Cys Ile Asn Asp Phe Ala Lys Tyr Pro Asp Ala Lys Thr Arg Lys Asn 
                405                 410                 415     


Pro Glu Pro Asp Ile Trp Leu Ser Ile Tyr Glu Leu Pro Ala Leu Val 
            420                 425                 430         


Phe Leu His Leu Leu Thr Lys Arg Asp Asp Gly Ser Ser Glu Ile Lys 
        435                 440                 445             


Trp Val Leu Tyr Arg His Asn Gln Asn Ile Lys Ser Phe Phe Ile Ala 
    450                 455                 460                 


Val Ala Glu Glu Asn Leu Gln Pro Gly Phe Thr Lys Glu Thr Leu Gln 
465                 470                 475                 480 


Thr Glu Leu Lys Lys Tyr Asn Leu Glu Tyr Asn His Ile Pro Lys Val 
                485                 490                 495     


Leu Ile Glu Tyr Leu Leu Lys Lys Thr Ala Lys Asn Val Gln Glu Lys 
            500                 505                 510         


Ala Glu Gly Lys Leu His Val Leu Ile Ser Glu Thr Ile Val Leu Leu 
        515                 520                 525             


Arg Lys Leu Asp Glu Asp Val Glu Lys Ala Lys Glu Lys Glu Gly Gly 
    530                 535                 540                 


Lys Arg Tyr Lys Pro Ile Gln Ser Gly Lys Ile Ala Asp Phe Ile Ala 
545                 550                 555                 560 


Arg Asp Met Leu Phe Leu Gln Pro Pro Val Asn Glu Lys Glu Gly Lys 
                565                 570                 575     


Ala Thr Ser Thr Leu Phe Gln Val Leu Gln Ala Arg Leu Ala Tyr Tyr 
            580                 585                 590         


Gly Arg Asp Lys Asn Leu Leu Asn Ser Leu Tyr Lys Glu Cys Asn Leu 
        595                 600                 605             


Ile Asp Ser Ala Asn Ala His Pro Phe Leu Asn Asn Val Pro Leu Ala 
    610                 615                 620                 


Tyr Ser Ile Val Asp Tyr Tyr Lys Asn Tyr Leu Leu Lys Arg Lys Glu 
625                 630                 635                 640 


Tyr Leu Glu Lys Leu Arg Glu Lys Cys Met Lys Gly Lys Ile Asn Ser 
                645                 650                 655     


Asn Glu Phe His Phe Leu His Leu Gly Ala Arg Glu Lys Arg Ser Gly 
            660                 665                 670         


Asp Ser Tyr Tyr Lys Asn Leu Ala Lys Thr Phe Ser Glu Lys Pro Ile 
        675                 680                 685             


Asn Phe Pro Arg Gly Leu Phe Leu Asn Ala Ile Lys Gln Gln Ser Lys 
    690                 695                 700                 


Asn Lys Asn Gly Glu Ser Ile Lys Lys Leu Leu Glu Glu His Glu Arg 
705                 710                 715                 720 


Val Asn Thr Ile Phe Leu Ile Gln Glu His Phe Lys Thr Val Glu Glu 
                725                 730                 735     


Asp Glu Ala Gln Pro Phe Tyr Asn Phe Glu Arg Asn Tyr Phe Leu Ile 
            740                 745                 750         


Asp Gln Leu Leu Asp Lys Arg Lys Gln Asn Ser Arg Glu Ala Arg Lys 
        755                 760                 765             


Gln Tyr Tyr Tyr Ser Ala Lys Glu Leu Ala Glu Glu Val Asn Lys Ile 
    770                 775                 780                 


Lys Glu Glu Ile Lys Lys Ile Pro Val Arg Tyr Asp Asp Glu Lys Arg 
785                 790                 795                 800 


Met Arg Ile Ile Ala Glu Lys Asn Tyr His His Leu Thr Glu Asn Glu 
                805                 810                 815     


Lys Ile Leu Arg His Ile Lys Thr Cys Asp Ile Ile Leu Phe Leu Leu 
            820                 825                 830         


Val Lys Asp Leu Leu Gln Ser Leu Glu Glu Pro Leu Phe Gly Ala Thr 
        835                 840                 845             


Asp Leu Lys Asn Ile Lys Leu Arg Asp Ile Met Pro Asp Ala Glu Lys 
    850                 855                 860                 


Gly Ile Leu Ser Met Pro Ile Asn Phe Lys Leu Lys Tyr Gly Asp Lys 
865                 870                 875                 880 


Phe Ile Cys Gln Asn Asn Met Lys Leu Lys Asn Tyr Gly Asp Phe Arg 
                885                 890                 895     


Arg Phe Leu Lys Asp Asn Arg Ile Lys Asn Leu Ile Thr Tyr Phe Pro 
            900                 905                 910         


Glu Lys Asp Ile Thr Lys Glu Lys Leu Glu Lys Glu Leu Glu Gln Tyr 
        915                 920                 925             


Asp Lys Ala Arg Ile Glu Val Gln Lys Ile Ile Leu Glu Phe Glu Lys 
    930                 935                 940                 


Gln Cys Ser Glu Arg Tyr Asn Ile Cys Ile Gly Asp Ser Asp Arg Tyr 
945                 950                 955                 960 


Ile Asp His Lys Thr Ile Leu Asp Lys Trp Gln Ala Asn Asn Leu Asn 
                965                 970                 975     


Asn Pro Asp Arg Asp Gln Met Glu Asp Leu Arg Ser Ser Phe Met His 
            980                 985                 990         


Asn Asp Tyr Pro Val Lys Ile Ser  Leu Asp Ala Lys Glu  Asp Ser Thr 
        995                 1000                 1005             


Ile Ala  Glu Lys Leu Val Glu  Lys Ala Arg Glu Leu  Phe Ile Leu 
    1010                 1015                 1020             


Asn 
    


<210>  2595
<211>  1091
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2595

Met Lys Glu Glu Glu Lys Gly Lys Thr Pro Val Val Ser Thr Tyr Asn 
1               5                   10                  15      


Lys Asp Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His 
            20                  25                  30          


Asn Val Tyr Ile Thr Val Asn His Ile Asn Lys Ile Leu Gly Glu Ala 
        35                  40                  45              


Glu Ile Asn Ile Asp Gly Tyr Asp Ile Ser Leu Lys Asn Ile Trp Ser 
    50                  55                  60                  


Gly Ile Arg Asp Ile Asn Lys Lys Ala Arg Leu Glu Glu Leu Met Ile 
65                  70                  75                  80  


Lys His Phe Pro Phe Leu Glu Ala Met Thr His Gln Gln Arg Leu Thr 
                85                  90                  95      


Gly Asn Thr Lys Gln Lys Glu Glu Lys Gln Ala Lys Ile Gln Ser Phe 
            100                 105                 110         


Glu Ile Leu Lys Asp Asn Leu Phe Leu Leu Leu Lys Met Leu Gln Asp 
        115                 120                 125             


Leu Arg Asn His Tyr Ser His Tyr Lys His Ser Lys Ser Leu Glu Arg 
    130                 135                 140                 


Pro Lys Phe Asp Glu Asp Ile Arg Asn Lys Leu Tyr Asn Ile Phe Asp 
145                 150                 155                 160 


Thr Ser Ile Arg Leu Val Lys Glu Asp Tyr Lys His Asn Pro Asp Ile 
                165                 170                 175     


Lys Pro Lys Glu His Phe Lys His Leu Asp Arg Lys Arg Asn Glu Lys 
            180                 185                 190         


Phe Arg Tyr Ser Phe Ala Asp Asn Glu Gly Asn Ile Thr Ile Ser Gly 
        195                 200                 205             


Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp 
    210                 215                 220                 


Val Gln Lys Lys Leu Glu Gly Phe Arg Cys Ser Asn Glu Ser Tyr Gln 
225                 230                 235                 240 


Lys Met Thr Asn Glu Val Phe Cys Arg Asn Arg Ile Leu Met Pro Lys 
                245                 250                 255     


Leu Arg Leu Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met 
            260                 265                 270         


Leu Asn Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Lys 
        275                 280                 285             


Gly Glu Asp Arg Lys Lys Phe Glu Val Pro Phe Asp Ser Thr Asp Glu 
    290                 295                 300                 


Asp Tyr Asp Ala Glu Gln Asp Pro Phe Lys Asn Thr Leu Ile Arg Tyr 
305                 310                 315                 320 


Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe Asp Tyr Asn Glu 
                325                 330                 335     


Ile Phe Glu Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe 
            340                 345                 350         


Ser Ile Tyr Lys Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg His Leu 
        355                 360                 365             


Thr His Lys Leu Tyr Gly Phe Glu Arg Leu Gln Glu Phe Ala Lys Gln 
    370                 375                 380                 


Asn Arg Pro Asp Glu Trp Lys Ala Ile Ile Lys Asp Leu Asp Thr Phe 
385                 390                 395                 400 


Lys Lys Gln Glu Asp Glu Lys Val Asn Glu Lys Pro Tyr Ile Ser Glu 
                405                 410                 415     


Thr Thr Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Ala Phe 
            420                 425                 430         


Lys Asn His Asn Ile Trp Pro Thr Thr Asn Thr Glu Phe Thr Asn Asn 
        435                 440                 445             


Lys Arg Lys Lys Tyr Asn Leu Gly Thr Ser Ile Lys Ala Glu Ala Phe 
    450                 455                 460                 


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Met Leu Leu 
465                 470                 475                 480 


Lys Ile Lys Asn Glu Gly Pro Arg Lys Val Glu Ala Ile Ile Glu Ser 
                485                 490                 495     


Lys Ile Lys Asp Ile Phe Thr Leu Tyr Asp Ala Phe Ala Asn Asp Glu 
            500                 505                 510         


Ile Asp Asn Thr Asp Glu Leu Glu Lys Tyr Cys Glu Asp Lys Asp Ile 
        515                 520                 525             


Lys Ile Gly His Leu Pro Lys Gln Met Ile Ala Ile Leu Tyr Asn Lys 
    530                 535                 540                 


His Lys Asp Met Val Glu Lys Ala Lys Val Lys Gln Glu Lys Met Lys 
545                 550                 555                 560 


Leu Ala Thr Glu Asn Arg Leu Lys Thr Leu Asp Lys Leu Ile Glu Gly 
                565                 570                 575     


Lys Met Lys Tyr Ala Lys Arg Gly Ile Ser Pro Leu Lys Ser Gly Glu 
            580                 585                 590         


Ile Ala Ser Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln 
        595                 600                 605             


Arg Asp Glu Asn Gly Glu Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr 
    610                 615                 620                 


Glu Tyr Gln Leu Leu Gln Arg Thr Leu Ala Leu Phe Gly Ser Glu His 
625                 630                 635                 640 


Lys Arg Leu Thr Pro Tyr Phe Lys Gln Met Asn Leu Ile Gly Asp Asn 
                645                 650                 655     


Asn Ser His Pro Phe Leu Lys Gln Thr Glu Trp Glu Glu Cys Asn Asn 
            660                 665                 670         


Ile Leu Ser Phe Tyr Arg Ser Tyr Leu Glu Ala Arg Lys Asn Phe Leu 
        675                 680                 685             


Lys Asn Leu Glu Pro Lys Asp Trp Lys Lys Asn Gln Tyr Phe Leu Lys 
    690                 695                 700                 


Ile Lys Glu Pro Lys Ser Asn Arg Gln Thr Leu Val Gln Gly Trp Lys 
705                 710                 715                 720 


Asn Gly Phe Asn Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Lys Lys 
                725                 730                 735     


Trp Phe Ile Glu His Arg Lys Lys Met Lys Val Asp Glu Leu Lys Ser 
            740                 745                 750         


Val Gly Leu Val Ala Lys Val Ile Pro Leu Tyr Phe Asn Glu Lys Tyr 
        755                 760                 765             


Lys Asp Ser Val Gln Pro Phe Tyr Asn Tyr Pro Phe Asn Val Gly Asp 
    770                 775                 780                 


Ile Asn Lys Pro Lys Glu Lys Asp Phe Leu Asp Asn Gly Lys Arg Arg 
785                 790                 795                 800 


Lys Leu Trp Asp Lys Lys Gln Leu Glu Phe Lys Gly Lys Thr Glu Glu 
                805                 810                 815     


Glu Lys Arg Lys Asn Pro Ser Tyr Leu Asp Phe Lys Ser Trp Lys Lys 
            820                 825                 830         


Phe Glu Arg Glu Leu Arg Leu Ile Arg Asn Gln Asp Ile Val Thr Trp 
        835                 840                 845             


Leu Met Cys Ile Glu Leu Tyr Asn Asn Gln Lys Val Glu Asn Leu Asn 
    850                 855                 860                 


Thr Gly His Ile Tyr Leu Lys Asp Ile Ile Thr Asn Val Lys Glu Glu 
865                 870                 875                 880 


Arg Asn Asn Asn Ile Leu Asn Gln Ile Lys Ser Met Gln Leu Pro Val 
                885                 890                 895     


Thr Val Tyr Glu Asn Glu Ser Ser Pro Lys Lys Lys Tyr Leu Arg Thr 
            900                 905                 910         


Ile Tyr Ile Glu Glu Asn Gly Thr Lys Leu Leu Lys Gln Gly Asn Phe 
        915                 920                 925             


Lys Ala Leu Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Val 
    930                 935                 940                 


Lys Thr Ser Ser Glu Ala Glu Ser Lys Arg Asn Pro Ile Ser Lys Leu 
945                 950                 955                 960 


Arg Val Glu His Glu Leu Arg Glu Tyr Gln Lys Ala Arg Ile Asp Ile 
                965                 970                 975     


Ile Lys Asp Met Leu Ala Leu Glu Lys Thr Leu Ile Asp Asn Tyr Asp 
            980                 985                 990         


Ser Leu Asp Thr Asp Asn Phe His  Asn Met Leu Thr Gly  Trp Leu Glu 
        995                 1000                 1005             


Leu Lys  Gly Glu Ala Ile Lys  Thr Lys Phe Asn Asn  Asp Val Lys 
    1010                 1015                 1020             


Leu Leu  Thr Ala Val Arg Asn  Ala Phe Ser His Asn  Gln Tyr Pro 
    1025                 1030                 1035             


Met Tyr  Asp Glu Asn Leu Phe  Ile Asn Ile Glu Arg  Phe Ser Leu 
    1040                 1045                 1050             


Ser Ser  Ser Arg Ile Leu Glu  Ser Lys Gly Leu Gly  Ile Ala Val 
    1055                 1060                 1065             


Lys Leu  Lys Glu Glu Val Ser  Asn Ala Ile Glu Lys  Ile Lys Asn 
    1070                 1075                 1080             


Glu Glu  Asp Ala Lys Lys Glu  Thr 
    1085                 1090     


<210>  2596
<211>  1146
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2596

Met Glu Glu Asp Thr Thr Met Val Ser Lys Asn Asn Pro Phe Glu Ile 
1               5                   10                  15      


Phe Phe Asn Glu Lys Ile His Ile Gly Ser Leu Ala Glu Lys Ala Lys 
            20                  25                  30          


Lys Asn Phe Ile Ser Asn Asn Val Asp Gly Pro Asn Lys Leu Ser Arg 
        35                  40                  45              


Leu Tyr Tyr Phe Ser Ile Gly His Ala Leu Lys Lys Ile Asp Tyr Asn 
    50                  55                  60                  


Ala Thr Phe Lys Cys Glu Phe Ser Lys Asp Arg Asp Glu Lys Ile Pro 
65                  70                  75                  80  


Thr Arg Phe Leu Asn Leu Cys Ser Asn Ser Phe Asp Asp Lys Arg Val 
                85                  90                  95      


Lys Tyr Met Asp Leu Leu Ile Gly Asp Ile Arg Asn Ile Cys Ser His 
            100                 105                 110         


Tyr Leu His Asn Phe Asp Lys Ile Ser Ile Ser Asp Asn Phe Thr Tyr 
        115                 120                 125             


Lys Glu Asn Gly Lys Thr Ile Thr Leu Leu Leu Glu Glu Val Phe Ala 
    130                 135                 140                 


Ser Phe Leu Asn Glu Ala Phe Glu Leu Ala Val Arg Gln Thr Cys Ser 
145                 150                 155                 160 


Lys Gly Lys Asn Asp Glu Thr Asp Lys Asp Val Val Ala Phe Leu Cys 
                165                 170                 175     


Asp Lys Phe Phe Ile Gly Lys Asn Leu Asn Ile Ser Lys Asp Glu Ala 
            180                 185                 190         


Ile Lys Arg Val Leu Tyr Ile Val Val Asp Lys Asp Ser Pro Val Met 
        195                 200                 205             


Asp Gly Ser His Val Leu Phe Thr Ala His Lys Gly Thr Tyr Leu Ser 
    210                 215                 220                 


Phe Tyr Ala Cys Leu Phe Phe Leu Ser Met Phe Leu Tyr Lys His Glu 
225                 230                 235                 240 


Ala Val Lys Leu Ile Ser Arg Ile Lys Gly Phe Lys Arg Ser Asp Lys 
                245                 250                 255     


Val Phe Ser Glu Lys Arg Asp Leu Phe Thr Phe Tyr Ser Lys Lys Val 
            260                 265                 270         


Ser Ser Arg Asp Val Thr Asn Glu Glu Glu Pro Leu Val Lys Phe Arg 
        275                 280                 285             


Asp Ile Ile Gln Tyr Leu Ser His Tyr Pro Thr Val Trp Asn Asp Phe 
    290                 295                 300                 


Leu Leu Leu Asn Pro Glu Asn Thr His Val Lys Asp Leu Leu Asn Gly 
305                 310                 315                 320 


Ile Val Ala Met Glu Ser Lys Arg Leu Phe Pro Lys Met Phe Val Asn 
                325                 330                 335     


Pro Val Lys Ala Gly Arg Phe Ile Ile Tyr Val Lys Tyr His Leu Phe 
            340                 345                 350         


Val Ser Leu Tyr Ser Lys Lys Ala Leu Glu Arg Glu Tyr Phe Asp Ala 
        355                 360                 365             


Glu Leu Thr Gly Ala Glu Glu Glu Lys Phe Asn Lys Ile Val Ser Asn 
    370                 375                 380                 


Ser Arg Glu Leu Leu Gly Val Cys Lys Lys Leu Asn Asp Leu Arg Ser 
385                 390                 395                 400 


Ser Ala Gln Ala Asn Arg Glu Asp Thr Glu Lys Glu Ala Lys Ile Lys 
                405                 410                 415     


Ala Cys Lys Glu Gln Ile Lys Glu Leu Val Asn Asn Gly Thr Asn Ala 
            420                 425                 430         


Glu Leu Glu Lys Ile Ala Lys Arg Ile Asp Ser Asn Leu Phe Ile Ser 
        435                 440                 445             


Ser Tyr Gly Arg Asn Gln Asp Arg Phe Met Thr Phe Ala Met Arg Tyr 
    450                 455                 460                 


Leu Ala Glu Thr Met Tyr Phe Gly Asp Asp Ala Leu Phe Glu Ile Tyr 
465                 470                 475                 480 


Arg Phe Glu Thr Ile Lys Glu Gln Val Asp Phe Phe Asn Glu Ala Lys 
                485                 490                 495     


Lys Glu Leu Asn Lys Lys Gln Tyr Asp Arg Ile Arg Met Lys His Gly 
            500                 505                 510         


Arg Val Thr Glu Phe Val Thr Tyr Gln Asp Leu Val Lys Asn His Ser 
        515                 520                 525             


Gly Met Pro Phe Val Phe Glu Asn Asn Ala Ile Gln Val Phe Ile Pro 
    530                 535                 540                 


Lys Glu Glu Gln Ser Ile Asn Ala Ile Asp Arg Asp Lys Leu Asn Gly 
545                 550                 555                 560 


Leu Gly Thr Phe Tyr Val Ile Gln Arg Ser Leu Met Val Tyr Leu Leu 
                565                 570                 575     


Glu His Ala Leu Phe His Asp Glu Glu Ile Ser Phe Arg Asp Leu Ile 
            580                 585                 590         


Thr Arg Tyr Asp Glu Val Arg His Asp Lys Leu Asp Glu Tyr Asn Lys 
        595                 600                 605             


Glu Leu Asn Ser Asp Val Ser Leu Ser Ala Glu Arg Lys Lys Glu Met 
    610                 615                 620                 


Lys Lys Leu Leu Pro Lys Arg Leu Leu Asn His Tyr Leu Pro Ala Glu 
625                 630                 635                 640 


Ser Asp Asn Ser Leu Ser Ala Lys Ala Ser Phe Tyr Asp Leu Ile Asp 
                645                 650                 655     


Lys Thr Glu Glu Gln Gly Lys Arg Tyr Thr Ser Leu Arg Lys Gln Ala 
            660                 665                 670         


Glu Lys Gly His Tyr Leu Glu Tyr Phe Asp Lys Lys Asn Lys Gly Lys 
        675                 680                 685             


Ser Tyr Lys Leu Val Phe Val Trp Glu Ala Trp Asn Arg Met Phe Phe 
    690                 695                 700                 


Ala Asp Ile Phe Arg Glu Gln Val Ala Glu Ser Ser Asp Gly Lys Asn 
705                 710                 715                 720 


His Lys His Phe Asn Val Thr Arg Asp Glu Tyr Lys Ile Phe Met Lys 
                725                 730                 735     


Trp Met Tyr Gly Leu Gly Asp Thr Pro Gln Tyr Lys Asp Cys Leu Gln 
            740                 745                 750         


Arg Leu Phe Gln Pro Lys Lys Phe Phe Glu Asn Asn Asp Phe Lys Leu 
        755                 760                 765             


Leu Phe Glu Arg Gly Asn Ser Leu Asp Asp Phe Tyr Gln Ser Thr Leu 
    770                 775                 780                 


Gln Leu Tyr Lys Gln Trp Ala Asp Arg Gln Ser Leu Pro Asn Lys Glu 
785                 790                 795                 800 


Asn Lys Tyr Lys Leu Glu Asn Tyr Val Asp Leu Leu Asp Ser Asn Ile 
                805                 810                 815     


Val Tyr Ile Asn Leu His Thr Phe Met Asp Val Met Arg Glu Arg Asn 
            820                 825                 830         


Ile Leu Asn Leu Lys Pro Asn Gly His Asn Lys Tyr Lys Thr Tyr Ser 
        835                 840                 845             


Asn Ile Lys Tyr Leu Ile Asp Phe Tyr Tyr Ile Ser Ala Thr Phe Asp 
    850                 855                 860                 


Ser Gly Tyr Glu Gly Lys Asp Lys Lys Glu Tyr Arg Lys Leu Tyr Asn 
865                 870                 875                 880 


Lys Leu Asn Ser Val Arg Ile Glu Asp Ala Leu Leu Tyr Glu Ile Ala 
                885                 890                 895     


Ile Lys Tyr Leu Ile Ser Ala Asn Ser Asn Asn Asn Asn Tyr Arg Ile 
            900                 905                 910         


Lys Thr Ser Val Thr Asn Phe Tyr Asp Arg Tyr Ile Leu Tyr Pro Ile 
        915                 920                 925             


Lys Asp Asn His Thr His Gln Arg Leu Tyr Asp Val Ser Ile Pro Phe 
    930                 935                 940                 


Asn Asn Ile Asp Ala Phe Asp Arg Leu Ile Ile Leu Asn Asn Glu Ser 
945                 950                 955                 960 


Asp Met Val Lys Gln Leu Lys Glu Tyr Leu Ser Glu Glu Lys Tyr Val 
                965                 970                 975     


Thr Val Phe Ser Thr Glu Glu Met Arg Thr Ile Arg Asn Ser Phe Ile 
            980                 985                 990         


Glu Asn Asn Val Ile Thr Tyr Asn  Asn Leu Val Lys Val  Thr Gln Lys 
        995                 1000                 1005             


Leu Gln  Gly Glu Ser Leu Gln  Phe Ser Asn Leu Ile  Leu Ala Ile 
    1010                 1015                 1020             


Glu Arg  Tyr Tyr Phe Asn Ser  Lys Asn Ile Ser Leu  Lys Asp Glu 
    1025                 1030                 1035             


Asp Gly  Gly Tyr Phe Ser Phe  Asp Ser Ser Ile Leu  Cys Asp Glu 
    1040                 1045                 1050             


Asp His  Gly Lys Ser Glu Phe  Asn Glu Ile Arg Arg  Ala Ala Cys 
    1055                 1060                 1065             


His Phe  Asp Ile Pro Pro Gln  Pro Tyr Arg Thr Tyr  Met Lys Lys 
    1070                 1075                 1080             


Met Glu  Gln Lys Phe Ile Glu  Lys Tyr Ile Val Pro  Ser Leu Pro 
    1085                 1090                 1095             


Met Ser  Trp Asn Ser Met Asn  Cys Ser Leu Gln Asp  Val Cys Arg 
    1100                 1105                 1110             


Met Phe  Met Val Thr Leu Asn  Gln Lys Arg Arg Asp  Glu Ser Asp 
    1115                 1120                 1125             


Glu Glu  Ala Phe Asn Arg Cys  Met Gln Gly Ile Ser  Gly Asn Ile 
    1130                 1135                 1140             


Lys Val  Gly 
    1145     


<210>  2597
<211>  1122
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2597

Met Lys Glu Glu Glu Thr Pro Val Val Ser Thr Tyr Asn Lys Asp Asp 
1               5                   10                  15      


Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val Tyr 
            20                  25                  30          


Ile Thr Ile Asn His Ile Asn Lys Leu Leu Glu Ile Arg Glu Ile Asp 
        35                  40                  45              


Asn Asp Glu Lys Val Leu Asp Ile Lys Ala Leu Trp Gln Lys Gly Asn 
    50                  55                  60                  


Lys Asp Leu Asn Gln Lys Ala Arg Leu Arg Glu Leu Met Thr Lys His 
65                  70                  75                  80  


Phe Pro Phe Leu Glu Thr Ala Ile Tyr Thr Lys Asn Lys Glu Asp Lys 
                85                  90                  95      


Lys Glu Val Lys Gln Glu Lys Gln Ala Glu Ala Gln Ser Leu Glu Ser 
            100                 105                 110         


Leu Lys Asp Tyr Leu Phe Leu Phe Leu Glu Lys Leu Gln Glu Ala Arg 
        115                 120                 125             


Asn Tyr Tyr Ser His Tyr Lys Tyr Ser Glu Ser Thr Lys Glu Pro Met 
    130                 135                 140                 


Leu Glu Lys Glu Leu Leu Lys Lys Met Tyr Asn Ile Phe Asp Asp Asn 
145                 150                 155                 160 


Ile Gln Leu Val Ile Lys Asp Tyr Gln His Asn Lys Asp Ile Asn Pro 
                165                 170                 175     


Asp Glu Asp Phe Lys His Leu Asp Arg Lys Gly Gln Phe Lys Tyr Ser 
            180                 185                 190         


Phe Ala Asp Asn Glu Gly Asn Ile Thr Glu Ser Gly Leu Leu Phe Phe 
        195                 200                 205             


Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Met Gln Gln Lys 
    210                 215                 220                 


Leu Thr Gly Phe Lys Asp Asn Arg Glu Asn Lys Lys Lys Met Thr His 
225                 230                 235                 240 


Glu Val Phe Cys Arg Ser Arg Met Leu Leu Pro Lys Leu Arg Leu Glu 
                245                 250                 255     


Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu Asn Glu Leu 
            260                 265                 270         


Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Lys Gly Glu Asp Arg 
        275                 280                 285             


Lys Lys Phe Glu Val Pro Phe Asp Ser Thr Asp Glu Asp Tyr Asp Ala 
    290                 295                 300                 


Glu Gln Asp Pro Phe Lys Asn Thr Leu Ile Arg His Gln Asp Arg Phe 
305                 310                 315                 320 


Pro Tyr Phe Val Leu Arg Tyr Phe Asp Tyr Asn Glu Ile Phe Lys Asn 
                325                 330                 335     


Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile Tyr Lys 
            340                 345                 350         


Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg His Leu Thr His Lys Leu 
        355                 360                 365             


Tyr Gly Phe Glu Arg Ile Gln Glu Phe Thr Lys Gln His Arg Pro Asp 
    370                 375                 380                 


Asp Trp Lys Ala Ile Val Lys Asp Phe Asp Thr Tyr Glu Thr Ser Glu 
385                 390                 395                 400 


Glu Pro Tyr Ile Ser Glu Thr Thr Pro His Tyr His Leu Glu Asn Gln 
                405                 410                 415     


Lys Ile Gly Ile Arg Phe Lys Asn Asp Asn Asp Lys Ile Trp Pro Ser 
            420                 425                 430         


Leu Glu Thr Asn Gly Glu Asn Asn Glu Lys Ser Lys Tyr Lys Leu Asp 
        435                 440                 445             


Lys Gln Tyr Gln Ala Glu Ala Phe Leu Ser Val His Glu Leu Leu Pro 
    450                 455                 460                 


Met Met Phe Tyr Tyr Leu Leu Leu Lys Lys Glu Glu Pro Asn Asn Asp 
465                 470                 475                 480 


Lys Lys Asn Ala Ser Arg Val Glu Gly Phe Ile Lys Arg Glu Ile Arg 
                485                 490                 495     


Asp Ile Phe Lys Leu Tyr Asp Ala Phe Ala Asn Asp Glu Ile Asn Asn 
            500                 505                 510         


Ile Asp Asp Leu Lys Lys Tyr Cys Lys Asp Lys His Val Glu Ile Arg 
        515                 520                 525             


His Leu Pro Lys Gln Met Ile Ala Ile Leu Glu Ser Lys Pro Lys Asp 
    530                 535                 540                 


Met Ala Lys Glu Ala Lys Arg Lys Gln Lys Glu Met Val Lys Asp Thr 
545                 550                 555                 560 


Lys Lys Leu Leu Ala Thr Leu Glu Lys Gln Thr Gln Lys Glu Lys Glu 
                565                 570                 575     


Asp Asp Gly Arg Asn Val Lys Leu Leu Lys Ser Gly Glu Ile Ala Arg 
            580                 585                 590         


Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln Lys Asp Asn 
        595                 600                 605             


Glu Gly Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln 
    610                 615                 620                 


Met Leu Gln Arg Ser Leu Ala Leu Tyr Asn Lys Glu Glu Asn Pro Thr 
625                 630                 635                 640 


Arg Tyr Phe Arg Gln Val Asn Leu Ile Glu Ser Ser Asn Pro His Pro 
                645                 650                 655     


Phe Leu Lys Trp Thr Lys Trp Glu Glu Cys Asn Asn Ile Leu Thr Phe 
            660                 665                 670         


Tyr His Arg Tyr Leu Thr Lys Lys Ile Glu Phe Leu Asn Lys Leu Lys 
        675                 680                 685             


Pro Glu Asp Trp Lys Lys Asn Gln Tyr Phe Leu Lys Leu Lys Glu Pro 
    690                 695                 700                 


Lys Thr Asn Arg Lys Thr Leu Val Gln Gly Trp Lys Asn Gly Phe Asn 
705                 710                 715                 720 


Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg Glu Trp Phe Glu Arg 
                725                 730                 735     


His Gln Asn Asp Ser Glu Glu Tyr Lys Lys Val Glu Lys Leu Asn Lys 
            740                 745                 750         


Ala Gly Leu Val Thr Lys Val Ile Pro Leu Phe Phe Lys Lys Glu Asp 
        755                 760                 765             


Ser Lys Asp Lys Glu Glu Tyr Leu Lys Lys Asp Thr Gln Lys Glu Ile 
    770                 775                 780                 


Asn Asp Cys Val Gln Pro Phe Tyr Asn Phe Pro Tyr Asn Val Gly Asn 
785                 790                 795                 800 


Ile His Lys Pro Asp Glu Lys Asp Phe Leu His Arg Glu Glu Arg Ile 
                805                 810                 815     


Glu Leu Trp Asp Lys Lys Lys Asp Lys Phe Lys Gly Tyr Lys Glu Lys 
            820                 825                 830         


Ile Lys Ser Lys Lys Leu Thr Glu Lys Glu Lys Glu Glu Phe Arg Ser 
        835                 840                 845             


Tyr Leu Glu Phe Gln Ser Trp Asn Asn Phe Glu Arg Glu Leu Arg Leu 
    850                 855                 860                 


Val Arg Asn Gln Asp Ile Val Thr Trp Leu Leu Cys Thr Glu Leu Ile 
865                 870                 875                 880 


Asp Lys Leu Lys Val Glu Gly Leu Asn Val Glu Glu Leu Gln Lys Leu 
                885                 890                 895     


Arg Leu Lys Asp Ile Asp Thr Asp Thr Ala Lys Gln Glu Lys Asn Asn 
            900                 905                 910         


Ile Leu Asn Arg Ile Met Pro Met Gln Leu Pro Val Thr Val Tyr Glu 
        915                 920                 925             


Ile Asp Asp Ser His Asn Ile Val Lys Asp Arg Pro Leu His Thr Val 
    930                 935                 940                 


Tyr Ile Glu Glu Thr Lys Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys 
945                 950                 955                 960 


Ala Leu Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Val Asp 
                965                 970                 975     


Thr Phe Glu Ala Glu Leu Lys Asp Lys Pro Ile Ser Lys Ser Val Val 
            980                 985                 990         


Glu Tyr Glu Leu Gly Glu Tyr Gln  Asn Ala Arg Ile Glu  Thr Ile Lys 
        995                 1000                 1005             


Asp Met  Leu Leu Leu Glu Glu  Thr Leu Ile Lys Lys  Tyr Lys Thr 
    1010                 1015                 1020             


Leu Pro  Thr Asn Lys Phe Ser  Ala Met Leu Asn Gly  Trp Leu Glu 
    1025                 1030                 1035             


Gly Lys  Asp Glu Ala Asp Lys  Ala Arg Phe Gln Asn  Asp Val Lys 
    1040                 1045                 1050             


Leu Leu  Val Ala Val Arg Asn  Ala Phe Ser His Asn  Gln Tyr Pro 
    1055                 1060                 1065             


Met Arg  Asn Arg Ile Ala Phe  Ala Asn Ile Asn Pro  Phe Ser Leu 
    1070                 1075                 1080             


Phe Ser  Ala Asp Thr Ser Glu  Glu Lys Lys Leu Asp  Ile Ala Asn 
    1085                 1090                 1095             


Gln Leu  Lys Asp Lys Thr Lys  Glu Thr Ile Asp Lys  Ile Ile Glu 
    1100                 1105                 1110             


Ile Glu  Lys Pro Ile Glu Thr  Lys Glu 
    1115                 1120         


<210>  2598
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2598

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2599
<211>  1242
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2599

Met Glu Gln Asn Arg Lys Glu Gly Ser Leu Arg Thr Gln Glu Asp Ile 
1               5                   10                  15      


Gln Tyr Phe Gly Ser Tyr Phe Asn Met Ala Arg His Asn Leu Tyr Leu 
            20                  25                  30          


Ile Thr Asn His Leu Thr Ser Val Phe Ser His Leu Asn Phe Ser Gln 
        35                  40                  45              


Leu Asp Asp Asp Glu Asp Ile Trp Ser Asp Lys Pro Glu Val Asn Glu 
    50                  55                  60                  


Lys Asn Ile Leu Leu Asn Ile Phe Asp Thr Lys Asn Glu Arg Leu Gln 
65                  70                  75                  80  


Asp Glu Arg Ile Arg Val Phe Arg Tyr Leu Met Arg Arg His His Leu 
                85                  90                  95      


Pro Cys Leu Arg Ile Phe Thr Asn Asp Phe Lys Val Leu Glu Thr Thr 
            100                 105                 110         


Gly Asn Thr Ile Lys Lys Asp Glu Leu Glu Val Asp Phe Asp Ala Val 
        115                 120                 125             


His Lys Phe Leu Asn Ile Ala Phe Lys Glu Ile Asn Leu Phe Arg Asn 
    130                 135                 140                 


Ser Tyr Thr His Tyr Leu Ser Ile Asn Glu Glu Gly Lys Arg Leu Lys 
145                 150                 155                 160 


Lys Lys Lys Lys Ile Ser Ser Lys Leu Val Pro Val Leu Asn Ser Leu 
                165                 170                 175     


Phe Ser Tyr Ala Pro Glu Tyr Ser Phe Leu Arg His Asn Ile Asp Lys 
            180                 185                 190         


Ala Asn Lys Asp Val Lys Ile Tyr Lys Glu Glu Val Lys Glu Tyr Tyr 
        195                 200                 205             


Asp Asn Ile Lys Ser Lys Tyr Lys Leu Phe Glu Asn Asp Ser Asn Glu 
    210                 215                 220                 


Leu Thr Asp Gln Gly Met Tyr Phe Phe Ile Thr Leu Phe Leu Glu Arg 
225                 230                 235                 240 


Ala His Gly Ile Lys Phe Leu Lys Arg Phe Arg Gly Phe Lys Asn Glu 
                245                 250                 255     


Thr Thr Pro Pro Phe Lys Ala Thr Ile Gln Ala Phe Thr Thr Tyr Thr 
            260                 265                 270         


Leu Lys Ile Pro Asp Val Arg Leu Asp Asn Asp Ile Pro Glu Gln Thr 
        275                 280                 285             


Met Ile Met Glu Val Leu Asn Glu Leu Asn Lys Cys Pro Glu Glu Leu 
    290                 295                 300                 


Phe Lys Phe Leu Lys Lys Glu Asp Lys Asp Arg Phe Gln Pro Val Ile 
305                 310                 315                 320 


Ser Asp Glu Ser Leu Thr Asn Ile Ile Asn Ser Ser Asn Tyr Glu Glu 
                325                 330                 335     


Ile Ser Asp Glu Asp Ile Asp Arg Leu Ile Lys Glu Asn Ser Val Leu 
            340                 345                 350         


Lys Arg Arg Glu Asp Arg Phe Pro Tyr Phe Ala Leu Gln Tyr Leu Glu 
        355                 360                 365             


Ile Met Ser Lys Leu Lys Asn Ile Arg Phe Gln Ile Tyr Leu Gly Lys 
    370                 375                 380                 


Leu Val Leu Lys Thr Tyr Asp Lys Glu Asn Pro Asn Ile Glu Arg Arg 
385                 390                 395                 400 


Val Ile Thr Asp Ile His Ala Phe Gly Lys Leu Ser Asp Phe Val Gly 
                405                 410                 415     


Lys Glu Ala Glu Val Leu Asp Thr Phe Asn Ser Gln Leu Lys Asp Tyr 
            420                 425                 430         


Gly Tyr Ser Val Ala Trp Asp Gln Tyr Lys Pro Ser Tyr Ala Ile Glu 
        435                 440                 445             


Met Asn Arg Ile Gly Phe Tyr Leu Phe Asn Asp Gln Gly Asp Lys Val 
    450                 455                 460                 


Glu Asn Lys Ile Leu Pro Ser Leu Cys Lys Asn Lys Asn Leu Glu Arg 
465                 470                 475                 480 


Lys Val Glu Ile Lys Val Asn Lys Ile Gln Pro Thr Gly Phe Ile Ser 
                485                 490                 495     


Thr His Met Leu Pro Lys Phe Leu Ile Ser Tyr Leu Met Gly Asp Val 
            500                 505                 510         


Asn Glu Lys Asn Gly Glu Lys Thr Ile Thr His Phe Leu Glu Lys Val 
        515                 520                 525             


Asn Val Ser Ile Leu Asp Gln Asn Ile Ile Asn Gln Ile Lys Ser Glu 
    530                 535                 540                 


Ile Gln Asn Leu Asp Pro Ile Glu Phe Thr Lys Arg Cys Pro Lys Leu 
545                 550                 555                 560 


Ser Ala Ile Lys Asn Val Lys Lys Leu Arg Val Ala Gly Ala Ile Asp 
                565                 570                 575     


Lys Lys Ile Val Glu Tyr Gln Tyr Ile Asn Asp Thr Asp Ile Ala Lys 
            580                 585                 590         


Leu Val Gln Lys Thr Gly Leu Ala Tyr Asp Thr Met Val Thr Tyr Ser 
        595                 600                 605             


Lys Asp Lys Phe Lys Glu Lys Thr Asn His Leu Asn Leu Ser Lys Lys 
    610                 615                 620                 


Glu Leu Glu Thr Phe Ala His Ile Lys Tyr Lys Tyr Tyr Leu Ser Glu 
625                 630                 635                 640 


Arg Arg Lys Ala Leu Asp Ser Val Leu Lys Ala Tyr Phe Pro Glu Ile 
                645                 650                 655     


Gly Ser Gln Asp Ile Pro Lys Glu Leu Tyr Asn Tyr Leu Leu Asn Ile 
            660                 665                 670         


Asn Glu Gln Asp Asn Lys Lys Leu Glu His Arg Arg Ile Lys Asp Glu 
        675                 680                 685             


Val Thr Lys Thr Lys Lys Leu Ile Lys Asp Val Asn Arg Ser Leu Lys 
    690                 695                 700                 


Phe Glu Asp Lys Ile Leu Leu Gly Asp Leu Ala Thr Lys Ile Ala Arg 
705                 710                 715                 720 


Asp Ile Ile Asn Met Ile Ile Asp Lys Asp Leu Lys Val Ser Met Thr 
                725                 730                 735     


Asn Pro Phe Ala Asn Arg Leu Gln Asn Leu Ile Ala Tyr Phe Ser Thr 
            740                 745                 750         


Asn Lys Glu Ala Ile Val Ala Leu Cys Glu Ser Tyr Lys Val Phe Glu 
        755                 760                 765             


His Asn Lys Gly His Phe Phe Leu Thr Arg Glu Leu Ile Leu Asn Ser 
    770                 775                 780                 


Thr Gly Val Ile Asp Phe Tyr Ile Arg Tyr Phe Glu Ala Lys Ile Glu 
785                 790                 795                 800 


Lys Ile Lys Glu Val Leu Leu Val Arg Gly Lys Glu Gly Gly Tyr Glu 
                805                 810                 815     


Ile Asn Thr Glu Leu Ile Pro Tyr Ser Tyr Thr Gln Tyr Leu Pro Lys 
            820                 825                 830         


Glu Val Lys Glu Glu Asn Lys Asn Thr Cys Lys Asn Leu Phe Glu Gln 
        835                 840                 845             


Trp Leu Tyr Tyr Lys Gln Lys Ser Pro Val Asn Leu Pro Val Thr Leu 
    850                 855                 860                 


Leu Asp Glu Asp Leu Thr Ser Ala Leu Lys Ser Lys Leu Lys Leu Lys 
865                 870                 875                 880 


Pro Asp Leu Lys Asp Gly Phe Ser Lys Leu Ile Gln Leu Tyr Leu Lys 
                885                 890                 895     


Asp Asp Ala Gln Glu Phe Tyr Ser Phe Asp Arg Val Tyr Arg Asn Asn 
            900                 905                 910         


Asp Asn Glu His Val Ile Lys Tyr Ser Asn Glu Gly Ser Ser Lys Glu 
        915                 920                 925             


Met Gln Ile Lys Tyr Gly Lys Val Ala Val Glu Ser Glu Lys Ile Ile 
    930                 935                 940                 


Arg His Val Leu Leu Lys Asp Arg Ile Leu Arg Val Ile Cys Glu Asp 
945                 950                 955                 960 


Leu Leu Lys Ser Asp Lys Asn Thr Ser Ser Thr Lys Ser Phe Leu Leu 
                965                 970                 975     


Lys Asp Ile Ser Pro Trp Ser Glu Thr Asn Ile Leu Asn Lys Pro Asn 
            980                 985                 990         


Glu Phe Ser Tyr Asn Leu Arg Lys  Asn Ile Asp Gly Ser  Gly Thr Glu 
        995                 1000                 1005             


Tyr Cys  Thr Ile Val Ala Lys  Asp Ser Thr Glu Gln  Ile Arg Gln 
    1010                 1015                 1020             


Ile Asn  Glu Trp Asn Asp Leu  Ser Lys Glu Ile Lys  Ser Lys Phe 
    1025                 1030                 1035             


Leu Lys  Leu Asn Ala Glu Gln  Lys Ile Asp Phe Leu  Thr Thr Gln 
    1040                 1045                 1050             


Asp Glu  Lys Thr Lys Leu Val  Leu Leu Gly Gln Gln  Asn Tyr Gln 
    1055                 1060                 1065             


Trp Lys  Phe Ser Asp Phe Gly  Arg Phe Arg Arg Phe  Met Lys Asp 
    1070                 1075                 1080             


Lys Arg  Ile Asn Glu Met Val  Lys Tyr Phe Glu Pro  Lys Gln Ile 
    1085                 1090                 1095             


Pro Phe  Asp Leu Leu Glu Phe  Gln Ile Leu Gln Tyr  Asn Ile Tyr 
    1100                 1105                 1110             


Arg Glu  Lys Met Phe Asp Lys  Ile Phe Glu Leu Glu  Arg Val Met 
    1115                 1120                 1125             


Ser Glu  Arg Tyr Phe Glu Asp  Ile Lys Ser Lys His  Leu Glu Asn 
    1130                 1135                 1140             


Phe Lys  Tyr Asn Glu Val Gly  Phe Gln Thr Tyr Leu  Asn Val Leu 
    1145                 1150                 1155             


Ser Glu  Lys Ile Ala Ser Gly  Tyr Asp Ile Ala Ile  Leu Lys Trp 
    1160                 1165                 1170             


Gly Arg  Asn Lys Phe Ser His  Thr Glu Ile Val Tyr  Tyr Asn Phe 
    1175                 1180                 1185             


Ile Ser  Lys Ile Ala Val Gln  Asp Ile Glu Glu Phe  Glu Leu Lys 
    1190                 1195                 1200             


Lys His  Leu Glu Gly Tyr Lys  Glu Asn Val Ser Phe  Asn Ile Ala 
    1205                 1210                 1215             


Arg Asn  Ile Tyr Arg Val Phe  Ser Arg Glu Val Asp  Lys Thr Ile 
    1220                 1225                 1230             


Asn Leu  Ile Asn Asn Ser Phe  Lys Ile 
    1235                 1240         


<210>  2600
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2600

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Leu Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Arg 
            740                 745                 750         


Ser Lys Phe Pro Asp Gly Glu Thr Asn Ile Val Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2601
<211>  1094
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2601

Met Lys Lys Tyr Tyr Asp Leu Tyr Lys Lys Asp Asp Lys His Phe Phe 
1               5                   10                  15      


Ala Gly Leu Phe Asn Thr Ala Val Asn Asn Phe Asp Leu Ser Ile Arg 
            20                  25                  30          


Glu Leu Glu Arg Arg Ile Lys Ser Lys Ser Asn Asn Ser Ile Gly Val 
        35                  40                  45              


Leu Lys Phe Ala Phe Ser Asn Glu Arg Pro Phe His Glu Leu Glu Asn 
    50                  55                  60                  


Asn Phe Asn Phe Leu Lys Glu Ser Leu Val Phe Met Asn Glu Ile Asn 
65                  70                  75                  80  


Gly Phe Tyr Asn Lys Lys Lys Thr Asn Lys Asp Ile Pro Glu Ser Gln 
                85                  90                  95      


Asn Ile Tyr Leu Phe Thr Gly Asp Phe Leu Val Glu Leu Tyr Asn Thr 
            100                 105                 110         


Leu Asn Ser Leu Arg Asn Tyr Tyr Thr His Tyr Glu His Ser Asp Ile 
        115                 120                 125             


Glu Ile Gly Asn Asp Ile Ala Asp Phe Leu Asn Asp Val Leu Phe His 
    130                 135                 140                 


Ser Ala Ile Arg Ile Lys Lys Asp Arg Ala Lys Asn Ala Asp Val Lys 
145                 150                 155                 160 


Ala Arg Leu Lys Thr Lys Tyr Lys Thr Glu Ile Asp Glu Tyr Phe Lys 
                165                 170                 175     


Ala His Asn Asn Lys Gly Glu Val Lys His Lys Ile Lys Gln Glu Asp 
            180                 185                 190         


Lys Thr Asn Tyr Val Ile Asn Lys Met Phe Asn Val Phe Phe Tyr Glu 
        195                 200                 205             


Asp Lys Asp Lys Asn Ile Phe Glu Leu Lys Asn Leu Val Lys Thr Lys 
    210                 215                 220                 


Asn Asn Glu Thr Asn Arg Leu Thr Lys Ser Gly Ile Ala Leu Val Leu 
225                 230                 235                 240 


Ser Leu Phe Leu Thr Lys Lys Gln Ile Asn Leu Leu Phe Asp Asn Phe 
                245                 250                 255     


Lys Tyr Phe Tyr Asp Asp Asp Ser Glu Leu Gln Lys Leu Ile Ile Arg 
            260                 265                 270         


Trp Val Tyr Thr Tyr Arg Ser Tyr Lys Ser Ile Arg Tyr Leu Phe Lys 
        275                 280                 285             


Ser Asp Tyr Asp Thr His Ser Leu Leu Leu Gln Met Val Asn Glu Leu 
    290                 295                 300                 


Asn Lys Ala Pro Lys His Leu Tyr Pro Tyr Leu Ser Glu Ala Lys Lys 
305                 310                 315                 320 


Lys Glu Phe Ile Glu Asp Val Asn Ile Tyr Leu Lys Asp Asn Ala Lys 
                325                 330                 335     


Asn Tyr Asp Asp Ser Leu Val Ala His Glu Val Ile Arg Arg Arg Tyr 
            340                 345                 350         


Glu Glu Lys Phe Ala Tyr Phe Ala Leu Arg Phe Leu Asp Asp Phe Ile 
        355                 360                 365             


Glu Phe Pro Thr Leu Arg Phe His Val Asn Leu Gly Lys Phe Asn His 
    370                 375                 380                 


Asn Ser Met Lys Lys Thr Tyr Lys Asn Asn Leu Ile Thr Glu Arg Ser 
385                 390                 395                 400 


Ile Leu Glu Lys Ile Asn Val Phe Glu Lys Leu Thr Met Val Thr Lys 
                405                 410                 415     


Lys Lys Lys Glu Tyr Phe Gln Asn Asn Asn Ile Asp Thr Glu Glu Gly 
            420                 425                 430         


Trp Arg Glu Phe Pro Met Pro Lys Tyr Val Phe His Gly Asn Ser Ile 
        435                 440                 445             


Gly Ile Tyr Leu Gly Lys Arg Asp Glu Val Glu Met Lys Arg Glu Glu 
    450                 455                 460                 


Asn Lys Pro Thr Lys Thr Ala Leu Ile Glu Lys Leu Gly Leu Pro Lys 
465                 470                 475                 480 


Asp Ala Tyr Gln Lys Pro Met Ala Phe Leu Ser Val Tyr Glu Leu Pro 
                485                 490                 495     


Ala Leu Leu His Tyr Leu Leu Val Asp Arg Lys Thr Pro Lys Glu Val 
            500                 505                 510         


Glu Glu Lys Ile Thr Gln Gln Ile Asn Lys Gln Lys Lys Glu Leu Asn 
        515                 520                 525             


Ser Ile Asp Glu Ser Asn Ile Ser Asp Ile Lys Ile Lys Lys Asp Ile 
    530                 535                 540                 


Ser Ile Asn Asn Lys Ile Ile Arg Lys Leu Thr Lys Ile Asn Asp Leu 
545                 550                 555                 560 


Lys Asn Phe Tyr Asp Leu Glu Lys Ile Lys Lys Ile Ile Glu Glu Glu 
                565                 570                 575     


Ile Lys Ile Ser Asp Pro Glu Asn Glu Lys Ser Pro Leu Lys Glu Ile 
            580                 585                 590         


Arg Lys Asn Tyr Lys Lys Thr Pro Lys Asn Pro Asn Ile Leu Ser Asn 
        595                 600                 605             


Ser Glu Lys Gly Lys Ile Ala Thr Trp Leu Ser Lys Asp Ile Lys Arg 
    610                 615                 620                 


Phe Thr Lys Lys Glu Val Arg Glu Asn Trp Lys Gly Tyr Gln Phe Ala 
625                 630                 635                 640 


Glu Phe Gln Ser Leu Leu Ser Tyr Tyr Asp Ile Asp Lys Asn Ala Val 
                645                 650                 655     


Lys Asn Phe Leu Leu Glu Asp Leu Tyr Glu Asn Lys Asn Leu Gln Asn 
            660                 665                 670         


Asn Phe Leu Leu Lys Asn Leu Asn Phe Asn Asn Ile Thr Leu Tyr Glu 
        675                 680                 685             


Phe Tyr Ile Asp Tyr Leu Thr Lys Arg Asn Thr Tyr Leu Glu Lys Lys 
    690                 695                 700                 


Leu Leu Leu Lys Leu Leu Gln Gly Lys Asp Lys Thr Asp Glu Ile Phe 
705                 710                 715                 720 


Val Phe Leu Pro Lys Asn Lys Phe Val Leu Thr Asp Ile Lys Asn Tyr 
                725                 730                 735     


Lys Ile Arg Lys Asn Asn Ala Pro Ile Met Leu Ser Arg Gly Ile Phe 
            740                 745                 750         


Tyr Asp Glu Pro Thr Gly Tyr Lys Pro Asp Asp Tyr Asn Lys Lys Asn 
        755                 760                 765             


Glu Leu Ala Glu Trp Phe Thr Lys Ala Ser Asp Ile Asp Lys Ala Gln 
    770                 775                 780                 


Glu Phe Tyr Lys Tyr Gln Arg Gln Tyr Pro Ile Asp Asp Asn Asn Phe 
785                 790                 795                 800 


Leu Ser Ile Asn Thr Asp Lys Gly Leu Lys Asp Gln Phe Ser Tyr Phe 
                805                 810                 815     


Glu Lys Thr Glu Asn Asn Gly Tyr Ile Thr Lys Thr Ile Asp Lys Lys 
            820                 825                 830         


Gln Gln Lys Phe Ile Tyr Lys Asn Glu Ala Lys Ile Arg Arg Thr Met 
        835                 840                 845             


Arg Asn Asp Tyr Tyr Ile Leu Gln Met Ile Lys His Phe Tyr Lys Glu 
    850                 855                 860                 


Ser Thr Glu Ile Asp Lys Gln Arg Leu Asp Lys Ile Thr Leu Lys Asp 
865                 870                 875                 880 


Phe Tyr Leu Thr Lys Ala Glu Lys Glu Lys Ile Gln Lys Glu Ala Ser 
                885                 890                 895     


Glu Lys Gln Asn Glu Phe Asn Gln Asp Phe Ile Leu Arg Lys Lys Val 
            900                 905                 910         


Glu Ile Ser Met Tyr Glu Gly Lys Ile Lys Gly Glu Val Lys Leu Lys 
        915                 920                 925             


Glu Ser Gly Lys Tyr Lys Arg Leu Leu Leu Asp Ser Lys Val Lys Met 
    930                 935                 940                 


Leu Thr Glu Tyr Phe Pro Asp Lys Lys Trp Thr Ile Asp Asp Ile Met 
945                 950                 955                 960 


Leu Glu Leu Asp Asn Tyr Glu Gln Val Arg Ser Lys Glu Phe Phe Lys 
                965                 970                 975     


Asn Val His Gln Leu Glu Gln Ile Ile Tyr Thr Lys Ala Asp Glu Gln 
            980                 985                 990         


Lys Glu Leu Glu Lys Leu Leu Leu  Asn Gly Phe Pro Asn  Phe Arg Lys 
        995                 1000                 1005             


Tyr Leu  Val Tyr Tyr Tyr Glu  Cys Pro Lys Leu Asp  Asn Ile Asn 
    1010                 1015                 1020             


Val Ile  Lys Thr Lys Leu Thr  Asp Leu Glu Thr Glu  Lys Glu Lys 
    1025                 1030                 1035             


Leu Leu  Phe Ile Leu Ile Met  Leu Arg Asn Lys Phe  Ala His Asn 
    1040                 1045                 1050             


Gln Leu  Val Pro Lys Glu Ile  Phe Val Tyr Leu Gln  Glu Lys Tyr 
    1055                 1060                 1065             


Thr Ile  Asn Lys Asn Glu Lys  Ile Gly Thr Tyr Leu  Asn Arg Val 
    1070                 1075                 1080             


Phe Glu  Lys Ile Tyr Glu Glu  Leu Asn Asn Asn 
    1085                 1090                 


<210>  2602
<211>  1147
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2602

Met Glu Ile Ala Pro Gln Gln Ser Glu Thr Gln Lys Lys Lys Arg Ser 
1               5                   10                  15      


Leu Asp Gln Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg 
            20                  25                  30          


His Asn Val Phe Leu Ile Val Asn His Leu Thr Asp Thr Phe Lys Glu 
        35                  40                  45              


Leu Asn Phe Lys Lys Leu Ala Asn Glu Glu Asp Ile Trp Lys Val Asp 
    50                  55                  60                  


Asn Ser Ser Asn Ile Leu Leu Asn Val Phe Asp Val Thr Gln Ser Lys 
65                  70                  75                  80  


Tyr Glu Asp Phe Arg Pro Arg Ile Phe His Tyr Leu Ile Lys Arg His 
                85                  90                  95      


His Leu Pro Leu Val Lys Ile Phe Asn Thr Glu Tyr Leu Gly Glu Asn 
            100                 105                 110         


Ile Leu Gln Asp Lys Ser Val Asp Tyr Glu Arg Leu His Gln Phe Leu 
        115                 120                 125             


Cys Leu Ser Phe Lys Glu Leu Thr Glu Phe Arg Asp Ser Tyr Ser His 
    130                 135                 140                 


Ser Ile Ala Ile Asp Glu Asn Gly Asn Lys Val Ser Arg Lys Thr Thr 
145                 150                 155                 160 


Leu Ala Asn Glu Leu Val Pro Glu Ile Asn Leu Leu Phe Lys Tyr Ala 
                165                 170                 175     


Pro Arg Tyr Ser Phe Leu Arg Asn Tyr Gln Thr Leu Asn Glu Gly Asp 
            180                 185                 190         


Phe Gln His Leu Asp Asn Tyr Gln Leu Phe Val Ala Asp Asn Gln Leu 
        195                 200                 205             


Thr His Gln Gly Arg Phe Phe Phe Ile Asn Leu Phe Leu Glu Arg Ser 
    210                 215                 220                 


Tyr Gly Ile Lys Phe Leu Lys Arg Phe Arg Gly Phe Lys Asn Glu Asn 
225                 230                 235                 240 


Thr Pro Pro Phe Lys Ala Thr Ile Gln Ser Phe Thr Thr Tyr Cys Leu 
                245                 250                 255     


Lys Val Pro Asp Ile Arg Leu Gly Asn Glu Asn Pro Lys Gln Ser Leu 
            260                 265                 270         


Leu Leu Asp Met Leu Thr Glu Leu Asn Lys Cys Pro Lys Glu Leu Phe 
        275                 280                 285             


Asn His Leu Thr Glu Asp Asp Lys Lys Glu Phe Glu Pro Asn Leu Asp 
    290                 295                 300                 


Glu Thr Ser Ser Thr Asn Val Leu Leu Asn Ser Thr Asn Tyr Glu Phe 
305                 310                 315                 320 


Phe Asp Ala Asp Glu Val Glu Glu Ala Ile Arg Glu Leu Thr Ala Gln 
                325                 330                 335     


Lys Arg His Asn Asp Arg Phe Pro Tyr Leu Ala Leu Arg Phe Leu Asp 
            340                 345                 350         


Glu Thr Met Ala Phe Ser Gln Leu Arg Phe Gln Leu Ser Leu Gly Lys 
        355                 360                 365             


Leu Ile Ile Lys Lys Pro Tyr Gln Lys Thr Ile Leu Gly Gln Pro Asn 
    370                 375                 380                 


Asp Arg Ile Ile Thr Lys Lys Leu Asn Val Phe Gly Arg Ile Ser Asp 
385                 390                 395                 400 


Phe Leu Asn Arg Glu Lys Glu Ile Ile Arg Ala Leu Ser Asn Asp Gln 
                405                 410                 415     


Asn Val Asp Phe Leu Glu Phe Glu Gln Phe Phe Pro His Tyr Asn Ile 
            420                 425                 430         


Asn Asn Asn Lys Ile Ala Phe Tyr Phe Leu Asn Asp Ser Asp Leu Thr 
        435                 440                 445             


Glu Glu Asn Leu Glu Ser Arg Leu Arg Asp Gln Glu Asn Arg Gln Pro 
    450                 455                 460                 


Thr Gly Phe Leu Ser Ile His Asp Leu Pro Lys Leu Val Leu Leu His 
465                 470                 475                 480 


Leu Leu Ala Pro Ser Glu Val Gln Lys Thr Leu Gln Arg Phe Ile Asn 
                485                 490                 495     


Asp Asn Asn Pro Ala Phe Phe Asp Leu Glu Leu Leu Ser Asn Ile Lys 
            500                 505                 510         


Ser Lys Val Val Tyr Glu Pro Ser Asn Phe Thr Lys Arg Ser Glu His 
        515                 520                 525             


Gln Tyr Arg Asp Ala Asp Lys Gln Glu Glu Glu Thr Glu Lys Gln Gln 
    530                 535                 540                 


Glu Tyr Gln Thr Leu Leu Asn Gln Arg Lys Arg Leu Leu Glu Gln His 
545                 550                 555                 560 


Leu Pro Lys Gly Val Lys Ile Asn Gln Ile Pro Glu Lys Val Leu Asp 
                565                 570                 575     


Phe Leu Met Asn Ile Ser Glu Pro Asn Glu Asn Lys Val Ile His Gln 
            580                 585                 590         


Lys Ile Lys Ser Ile Lys Asp Glu Ala Lys Thr Leu Leu Gln Arg Val 
        595                 600                 605             


Lys Asn Lys Gln Ala Ala Asn Glu Ile Pro Lys Leu Gly Glu Leu Ala 
    610                 615                 620                 


Thr Phe Leu Thr Arg Asp Ile Ile Asn Met Val Val Ser Glu Glu Leu 
625                 630                 635                 640 


Lys Lys Lys Ile Thr Ser Pro Tyr Ser Asn Lys Leu Gln Asn Lys Ile 
                645                 650                 655     


Ala Phe Phe Ser Leu Ser Lys Gln Glu Ile Ile Ser Leu Leu Asn Glu 
            660                 665                 670         


Leu Gln Leu Leu Asn Asn Glu Lys Gly His Val Phe Leu Ser Ser Arg 
        675                 680                 685             


Leu Ile Leu Glu Ser Asn Gly Leu Leu Ser Phe Tyr Lys Ser Tyr Leu 
    690                 695                 700                 


Glu Ala Lys Ile Ala Trp Ile Asp Lys Asn Leu Phe Leu Lys Gly Lys 
705                 710                 715                 720 


Lys Gly Gly Tyr Ile Ile Pro Glu Asn Lys Pro Val Pro Lys Thr Leu 
                725                 730                 735     


Gln Lys Ile Lys Gln Glu Val Ser Gln Phe Asp Phe Thr Gln Trp Leu 
            740                 745                 750         


Gln Asn Lys Ala Ala Met Pro Ile Asp Val Pro Asn Thr Ile Phe Asp 
        755                 760                 765             


Val Thr Leu Glu Asn Leu Leu Lys Thr Asn Leu Lys Lys Arg Gly Ile 
    770                 775                 780                 


Thr Val Lys Asp Thr Asp Lys Phe Ser Val Leu Leu Asn Lys Tyr Met 
785                 790                 795                 800 


Asp Lys Asp Thr Gln Pro Phe Tyr Gln Tyr Ser Arg Val Tyr Lys Lys 
                805                 810                 815     


Gln Asp Glu Glu Glu Ser Val Gln Val Val Gly Lys Trp Gly Lys Thr 
            820                 825                 830         


Leu Lys Lys Gln Tyr Gly Lys Phe Val Glu Glu Asn Glu Lys Val Ile 
        835                 840                 845             


Arg Phe Tyr Gln Ser Lys Asp Arg Val Ile Lys Leu Met Cys Asn Ala 
    850                 855                 860                 


Leu Leu Gln Ala Glu Asn Lys Thr Ala Leu Thr Asp Ser Phe Lys Leu 
865                 870                 875                 880 


Ala His Thr His Pro Asn Ser Lys Gln Asn Pro Leu Asp Thr Pro Met 
                885                 890                 895     


Arg Phe Glu Gln Lys Leu Phe Ser Asn Asp Lys Glu Thr Lys Val Leu 
            900                 905                 910         


Cys Thr Ile Tyr Ala Gln Asp Thr Glu Asn Gln Lys Asn Glu Ile Leu 
        915                 920                 925             


Ala Trp Asn Ser Leu Ser Glu Asp Asp Lys Lys Tyr Trp Leu Thr Leu 
    930                 935                 940                 


Thr Thr Lys Glu Ala Gln Lys Glu Trp Leu Ser Gly Lys Pro Glu Thr 
945                 950                 955                 960 


Glu Gln Glu Val Tyr His Gly Gln Lys Gly Tyr Gln Trp Thr Ile Lys 
                965                 970                 975     


Glu Val Gly Lys Phe Lys Arg Phe Val Lys Asp Arg Arg Ile Pro Ala 
            980                 985                 990         


Leu Val Asn Tyr Phe Glu Thr Thr  Lys Leu Pro Phe Ser  Leu Leu Glu 
        995                 1000                 1005             


Tyr Gln  Leu Lys Glu Tyr Asp  Arg Val Arg Glu Gln  Ile Phe Asp 
    1010                 1015                 1020             


Gly Val  Phe Lys Leu Glu Glu  Ala Ile Ser Gln Lys  Asp Trp Ala 
    1025                 1030                 1035             


Gly Ile  Trp Ala Leu Glu Gln  Glu Ala Arg Gly Arg  Lys Asn Tyr 
    1040                 1045                 1050             


His Gln  Val Gln Phe Asn Ile  Phe Glu Lys Tyr Leu  Gln Asn Thr 
    1055                 1060                 1065             


Leu Pro  Ser Tyr Asp Pro Ala  Ile Gly Val Ile Arg  Asn Lys Phe 
    1070                 1075                 1080             


Ser His  Asn Glu Phe Pro Asp  Leu Ile Gly Gln Gly  Ile Glu Lys 
    1085                 1090                 1095             


Ile Ser  Gln Ala Gln Ile Asp  Asp Tyr Glu Arg Asn  Lys His Leu 
    1100                 1105                 1110             


Lys Asp  Tyr Leu Ala His Ala  Gly Ile Ser Ile Ala  Gln Gln Ile 
    1115                 1120                 1125             


Leu Val  Ile Phe Glu Gln Lys  Ile Asn Asp Thr Leu  Thr Gln Leu 
    1130                 1135                 1140             


Thr Thr  His Gly 
    1145         


<210>  2603
<211>  1147
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2603

Met Glu Ile Ala Pro Gln Gln Ser Glu Thr Gln Lys Lys Lys Arg Ser 
1               5                   10                  15      


Leu Asp Gln Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg 
            20                  25                  30          


His Asn Val Phe Leu Ile Val Asn His Leu Thr Asp Thr Phe Lys Glu 
        35                  40                  45              


Leu Asn Phe Lys Lys Leu Ala Asn Glu Glu Asp Ile Trp Lys Val Asp 
    50                  55                  60                  


Asn Ser Ser Asn Ile Leu Leu Asn Val Phe Asp Val Thr Gln Ser Lys 
65                  70                  75                  80  


Tyr Glu Asp Phe Arg Pro Arg Ile Phe His Tyr Leu Ile Lys Arg His 
                85                  90                  95      


His Leu Pro Leu Val Lys Ile Phe Asn Thr Glu Tyr Leu Gly Glu Asn 
            100                 105                 110         


Ile Leu Gln Asp Lys Ser Val Asp Tyr Glu Arg Leu His Gln Phe Leu 
        115                 120                 125             


Cys Leu Ser Phe Lys Glu Leu Thr Glu Phe Arg Asp Ser Tyr Ser His 
    130                 135                 140                 


Ser Ile Ala Ile Asp Glu Asn Gly Asn Lys Val Ser Arg Lys Thr Thr 
145                 150                 155                 160 


Leu Ala Asn Glu Leu Val Pro Glu Ile Asn Leu Leu Phe Lys Tyr Ala 
                165                 170                 175     


Pro Arg Tyr Ser Phe Leu Arg Asn Tyr Gln Thr Leu Asn Glu Gly Asp 
            180                 185                 190         


Phe Gln His Leu Asp Asn Tyr Gln Leu Phe Val Ala Asp Asn Gln Leu 
        195                 200                 205             


Thr His Gln Gly Arg Phe Phe Phe Ile Asn Leu Phe Leu Glu Arg Ser 
    210                 215                 220                 


Tyr Gly Ile Lys Phe Leu Lys Arg Phe Arg Gly Phe Lys Asn Glu Asn 
225                 230                 235                 240 


Thr Pro Pro Phe Lys Ala Thr Ile Gln Ser Phe Thr Thr Tyr Cys Leu 
                245                 250                 255     


Lys Val Pro Asp Ile Arg Leu Gly Asn Glu Asn Pro Lys Gln Ser Leu 
            260                 265                 270         


Leu Leu Asp Met Leu Thr Glu Leu Asn Lys Cys Pro Lys Glu Leu Phe 
        275                 280                 285             


Asn His Leu Thr Glu Asp Asp Lys Lys Glu Phe Glu Pro Asn Leu Asp 
    290                 295                 300                 


Glu Thr Ser Ser Thr Asn Val Leu Leu Asn Ser Thr Asn Tyr Glu Phe 
305                 310                 315                 320 


Phe Asp Ala Asp Glu Val Glu Glu Ala Ile Arg Glu Leu Thr Ala Gln 
                325                 330                 335     


Lys Arg His Asn Asp Arg Phe Pro Tyr Leu Ala Leu Arg Phe Leu Asp 
            340                 345                 350         


Glu Thr Met Ala Phe Ser Gln Leu Arg Phe Gln Leu Ser Leu Gly Lys 
        355                 360                 365             


Leu Ile Ile Lys Lys Pro Tyr Gln Lys Thr Ile Leu Gly Gln Pro Asn 
    370                 375                 380                 


Asp Arg Ile Ile Thr Lys Lys Leu Asn Val Phe Gly Arg Ile Ser Asp 
385                 390                 395                 400 


Phe Leu Asn Arg Glu Lys Glu Ile Ile Arg Ala Leu Ser Asn Asp Gln 
                405                 410                 415     


Asn Val Asp Phe Leu Glu Phe Glu Gln Phe Phe Pro His Tyr Asn Ile 
            420                 425                 430         


Asn Asn Asn Lys Ile Ala Phe Tyr Phe Leu Asn Asp Ser Asp Leu Thr 
        435                 440                 445             


Glu Glu Asn Leu Glu Ser Arg Leu Arg Asp Gln Glu Asn Arg Gln Pro 
    450                 455                 460                 


Thr Gly Phe Leu Ser Ile His Asp Leu Pro Lys Leu Val Leu Leu His 
465                 470                 475                 480 


Leu Leu Ala Pro Ser Glu Val Gln Lys Thr Leu Gln Arg Phe Ile Asn 
                485                 490                 495     


Asp Asn Asn Pro Ala Phe Phe Asp Leu Glu Leu Leu Ser Asn Ile Lys 
            500                 505                 510         


Ser Lys Val Val Tyr Glu Pro Ser Asn Phe Thr Lys Arg Ser Glu His 
        515                 520                 525             


Gln Tyr Arg Asp Ala Asp Lys Gln Glu Glu Glu Thr Glu Lys Gln Gln 
    530                 535                 540                 


Glu Tyr Gln Thr Leu Leu Asn Gln Arg Lys Arg Leu Leu Glu Gln His 
545                 550                 555                 560 


Leu Pro Lys Gly Val Lys Ile Asn Gln Ile Pro Glu Lys Val Leu Asp 
                565                 570                 575     


Phe Leu Met Asn Ile Ser Glu Pro Asn Glu Asn Lys Val Ile His Gln 
            580                 585                 590         


Lys Ile Lys Ser Ile Lys Asp Glu Ala Lys Thr Leu Leu Gln Arg Val 
        595                 600                 605             


Lys Asn Lys Gln Ala Ala Asn Glu Ile Pro Lys Leu Gly Glu Leu Ala 
    610                 615                 620                 


Thr Phe Leu Thr Arg Asp Ile Ile Asn Met Val Val Ser Glu Glu Leu 
625                 630                 635                 640 


Lys Lys Lys Ile Thr Ser Pro Tyr Ser Asn Lys Leu Gln Asn Lys Ile 
                645                 650                 655     


Ala Phe Phe Ser Leu Ser Lys Gln Glu Ile Ile Ser Leu Leu Asn Glu 
            660                 665                 670         


Leu Gln Leu Leu Asn Asn Glu Lys Gly His Val Phe Leu Ser Ser Arg 
        675                 680                 685             


Leu Ile Leu Glu Ser Asn Gly Leu Leu Ser Phe Tyr Lys Ser Tyr Leu 
    690                 695                 700                 


Glu Ala Lys Ile Ala Trp Ile Asp Lys Asn Leu Phe Leu Lys Gly Lys 
705                 710                 715                 720 


Lys Gly Gly Tyr Ile Ile Pro Glu Asn Lys Pro Val Pro Lys Thr Leu 
                725                 730                 735     


Gln Lys Ile Lys Gln Glu Val Ser Gln Phe Asp Phe Thr Gln Trp Leu 
            740                 745                 750         


Gln Asn Lys Ala Ala Met Pro Ile Asp Val Pro Asn Thr Ile Phe Asp 
        755                 760                 765             


Val Thr Leu Glu Asn Leu Leu Lys Thr Asn Leu Lys Lys Arg Gly Ile 
    770                 775                 780                 


Thr Val Lys Asp Thr Asp Lys Phe Ser Val Leu Leu Asn Lys Tyr Met 
785                 790                 795                 800 


Asp Lys Asp Thr Gln Pro Phe Tyr Gln Tyr Ser Arg Val Tyr Lys Lys 
                805                 810                 815     


Gln Asp Glu Glu Glu Ser Val Gln Val Val Gly Lys Trp Gly Lys Thr 
            820                 825                 830         


Leu Lys Lys Gln Tyr Gly Lys Phe Val Glu Glu Asn Glu Lys Val Ile 
        835                 840                 845             


Arg Phe Tyr Gln Ser Lys Asp Arg Val Ile Lys Leu Met Cys Asn Ala 
    850                 855                 860                 


Leu Leu Gln Ala Glu Asn Lys Thr Ala Leu Thr Asp Ser Phe Lys Leu 
865                 870                 875                 880 


Ala His Thr His Pro Asn Ser Lys Gln Asn Pro Leu Asp Thr Pro Met 
                885                 890                 895     


Arg Phe Glu Gln Lys Leu Phe Ser Asn Asp Lys Glu Thr Lys Val Leu 
            900                 905                 910         


Cys Thr Ile Tyr Ala Gln Asp Thr Glu Asn Gln Lys Asn Glu Ile Leu 
        915                 920                 925             


Ala Trp Asn Ser Leu Ser Glu Asp Asp Lys Lys Tyr Trp Leu Thr Leu 
    930                 935                 940                 


Thr Thr Lys Glu Ala Gln Lys Glu Trp Leu Ser Gly Lys Pro Glu Thr 
945                 950                 955                 960 


Glu Gln Glu Val Tyr His Gly Gln Lys Gly Tyr Gln Trp Thr Ile Lys 
                965                 970                 975     


Glu Val Gly Lys Phe Lys Arg Phe Val Lys Asp Arg Arg Ile Pro Ala 
            980                 985                 990         


Leu Val Asn Tyr Phe Glu Thr Thr  Lys Leu Pro Phe Ser  Leu Leu Glu 
        995                 1000                 1005             


Tyr Gln  Leu Lys Glu Tyr Asp  Arg Val Arg Glu Gln  Ile Phe Asp 
    1010                 1015                 1020             


Gly Val  Phe Lys Leu Glu Glu  Ala Ile Ser Gln Lys  Asp Trp Ala 
    1025                 1030                 1035             


Gly Ile  Trp Ala Leu Glu Gln  Glu Ala Arg Gly Arg  Lys Asn Tyr 
    1040                 1045                 1050             


His Gln  Val Gln Phe Asn Ile  Phe Glu Lys Tyr Leu  Gln Asn Thr 
    1055                 1060                 1065             


Leu Pro  Ser Tyr Asp Pro Ala  Ile Gly Val Ile Arg  Asn Lys Phe 
    1070                 1075                 1080             


Ser His  Asn Glu Phe Pro Asp  Leu Ile Gly Gln Gly  Ile Glu Lys 
    1085                 1090                 1095             


Ile Ser  Gln Ala Gln Ile Asp  Asp Tyr Glu Arg Asn  Lys His Leu 
    1100                 1105                 1110             


Lys Asp  Tyr Leu Ala His Ala  Gly Ile Ser Ile Ala  Gln Gln Ile 
    1115                 1120                 1125             


Leu Val  Ile Phe Glu Gln Lys  Ile Asn Asp Thr Leu  Thr Gln Leu 
    1130                 1135                 1140             


Thr Thr  His Gly 
    1145         


<210>  2604
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2604

Leu Gln Lys Gln Asp Lys Leu Phe Val Asp Arg Lys Lys Asn Ala Ile 
1               5                   10                  15      


Phe Ala Phe Pro Lys Tyr Ile Thr Ile Met Glu Asn Lys Glu Lys Thr 
            20                  25                  30          


Lys Pro Ile Tyr Tyr Glu Leu Thr Asp Lys His Phe Trp Ala Ala Phe 
        35                  40                  45              


Leu Asn Leu Ala Arg His Asn Val Tyr Thr Thr Val Asn His Ile Asn 
    50                  55                  60                  


Lys Leu Leu Glu Ile Ala Glu Leu Lys Asn Asp Glu Asp Val Leu Asn 
65                  70                  75                  80  


Ile Lys Asp Ser Trp Asn Lys Gln Ala Glu Lys Leu Asp Lys Lys Val 
                85                  90                  95      


Arg Leu Arg Asn Leu Leu Met Arg His Phe Pro Phe Leu Glu Ala Ala 
            100                 105                 110         


Ala Tyr Glu Lys Thr Thr Ser Lys Asp Ser Asn Ser Lys Glu Gln Lys 
        115                 120                 125             


Glu Lys Glu Gln Ala Glu Ala Leu Ser Leu Asp Asn Leu Lys Asn Val 
    130                 135                 140                 


Leu Phe Ile Phe Leu Glu Lys Leu Gln Ser Leu Arg Asn Tyr Tyr Ser 
145                 150                 155                 160 


His Tyr Lys Tyr Ser Glu Glu Ala Gln Lys Pro Thr Phe Glu Asn Asp 
                165                 170                 175     


Leu Leu Lys Asn Met Tyr Lys Ile Phe Asp Thr Asn Val Arg Leu Val 
            180                 185                 190         


Lys Arg Asp Tyr Met His His Glu Asn Val Asp Met Gln Arg Asp Phe 
        195                 200                 205             


Ser His Leu Asn Arg Lys Lys Gln Glu Gly Gln Thr Arg Lys Ile Ile 
    210                 215                 220                 


Ala Asn Pro Asn Phe Arg Tyr His Phe Ala Asp Glu Lys Gly Asn Met 
225                 230                 235                 240 


Thr Ile Ala Gly Leu Leu Phe Phe Ile Ser Leu Phe Leu Asp Lys Lys 
                245                 250                 255     


Asp Ala Ile Trp Met Gln Lys Lys Leu Lys Gly Phe Lys Asp Gly Arg 
            260                 265                 270         


Asn Leu Arg Glu Gln Met Thr Asn Glu Val Phe Cys Arg Ser Arg Ile 
        275                 280                 285             


Ser Leu Pro Lys Leu Lys Leu Glu Asn Val Gln Thr Lys Asp Trp Met 
    290                 295                 300                 


Gln Leu Asp Met Leu Asn Glu Leu Val Arg Cys Pro Lys Ser Leu Tyr 
305                 310                 315                 320 


Glu Arg Leu Arg Glu Lys Asp Arg Glu Ser Phe Lys Val Pro Phe Asp 
                325                 330                 335     


Ile Phe Ser Asp Asp Tyr Asp Ala Glu Glu Glu Pro Phe Lys Asn Thr 
            340                 345                 350         


Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe 
        355                 360                 365             


Asp Leu Asn Glu Ile Phe Glu Gln Leu Arg Phe Gln Ile Asp Leu Gly 
    370                 375                 380                 


Thr Tyr His Phe Ser Ile Tyr Asn Lys Leu Ile Gly Asp Glu Asp Glu 
385                 390                 395                 400 


Val Arg His Leu Thr His His Leu Tyr Gly Phe Ala Arg Ile Gln Asp 
                405                 410                 415     


Phe Ala Pro Gln Asn Gln Pro Glu Glu Trp Arg Lys Leu Val Lys Asp 
            420                 425                 430         


Leu Asp His Phe Glu Thr Ser Gln Lys Pro Tyr Ile Ser Lys Thr Ala 
        435                 440                 445             


Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Lys Phe Cys Ser 
    450                 455                 460                 


Thr His Asn Asn Leu Phe Pro Ser Leu Lys Arg Glu Lys Thr Cys Asn 
465                 470                 475                 480 


Gly Arg Ser Lys Phe Asn Leu Gly Thr Gln Phe Thr Ala Glu Ala Phe 
                485                 490                 495     


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu 
            500                 505                 510         


Thr Lys Asp Tyr Ser Arg Lys Glu Ser Ala Asp Lys Val Glu Gly Ile 
        515                 520                 525             


Ile Arg Lys Glu Ile Ser Asn Ile Tyr Ala Ile Tyr Asp Ala Phe Ala 
    530                 535                 540                 


Asn Gly Glu Ile Asn Ser Ile Ala Asp Leu Thr Cys Arg Leu Gln Lys 
545                 550                 555                 560 


Thr Asn Ile Leu Gln Gly His Leu Pro Lys Gln Met Ile Ser Ile Leu 
                565                 570                 575     


Glu Gly Arg Gln Lys Asp Met Glu Lys Glu Ala Glu Arg Lys Ile Gly 
            580                 585                 590         


Glu Met Ile Asp Asp Thr Gln Arg Arg Leu Asp Leu Leu Cys Lys Gln 
        595                 600                 605             


Thr Asn Gln Lys Ile Arg Ile Gly Lys Arg Asn Ala Gly Leu Leu Lys 
    610                 615                 620                 


Ser Gly Lys Ile Ala Asp Trp Leu Val Asn Asp Met Met Arg Phe Gln 
625                 630                 635                 640 


Pro Val Gln Lys Asp Gln Asn Asn Ile Pro Ile Asn Asn Ser Lys Ala 
                645                 650                 655     


Asn Ser Thr Glu Tyr Arg Met Leu Gln Arg Ala Leu Ala Leu Phe Gly 
            660                 665                 670         


Ser Glu Asn Phe Arg Leu Lys Ala Tyr Phe Asn Gln Met Asn Leu Val 
        675                 680                 685             


Gly Asn Asp Asn Pro His Pro Phe Leu Ala Glu Thr Gln Trp Glu His 
    690                 695                 700                 


Gln Thr Asn Ile Leu Ser Phe Tyr Arg Asn Tyr Leu Glu Ala Arg Lys 
705                 710                 715                 720 


Lys Tyr Leu Lys Gly Leu Lys Pro Gln Asn Trp Lys Gln Tyr Gln His 
                725                 730                 735     


Phe Leu Ile Leu Lys Val Gln Lys Thr Asn Arg Asn Thr Leu Val Thr 
            740                 745                 750         


Gly Trp Lys Asn Ser Phe Asn Leu Pro Arg Gly Ile Phe Thr Gln Pro 
        755                 760                 765             


Ile Arg Glu Trp Phe Glu Lys His Asn Asn Ser Lys Arg Ile Tyr Asp 
    770                 775                 780                 


Gln Ile Leu Ser Phe Asp Arg Val Gly Phe Val Ala Lys Ala Ile Pro 
785                 790                 795                 800 


Leu Tyr Phe Ala Glu Glu Tyr Lys Asp Asn Val Gln Pro Phe Tyr Asp 
                805                 810                 815     


Tyr Pro Phe Asn Ile Gly Asn Lys Leu Lys Pro Gln Lys Gly Gln Phe 
            820                 825                 830         


Leu Asp Lys Glu Glu Arg Val Glu Leu Trp Gln Lys Asn Lys Glu Leu 
        835                 840                 845             


Phe Lys Asn Tyr Pro Ser Glu Lys Lys Lys Thr Asp Leu Ala Tyr Leu 
    850                 855                 860                 


Asp Phe Leu Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys 
865                 870                 875                 880 


Asn Gln Asp Ile Val Thr Trp Leu Met Phe Lys Glu Leu Phe Lys Thr 
                885                 890                 895     


Thr Thr Val Glu Gly Leu Lys Ile Gly Glu Ile His Leu Arg Asp Ile 
            900                 905                 910         


Asp Thr Asn Thr Ala Asn Glu Glu Ser Asn Asn Ile Leu Asn Arg Ile 
        915                 920                 925             


Met Pro Met Lys Leu Pro Val Lys Thr Tyr Glu Thr Asp Asn Lys Gly 
    930                 935                 940                 


Asn Ile Leu Lys Glu Arg Pro Leu Ala Thr Phe Tyr Ile Glu Glu Thr 
945                 950                 955                 960 


Glu Thr Lys Val Leu Lys Gln Gly Asn Phe Lys Val Leu Ala Lys Asp 
                965                 970                 975     


Arg Arg Leu Asn Gly Leu Leu Ser Phe Ala Glu Thr Thr Asp Ile Asp 
            980                 985                 990         


Leu Glu Lys Asn Pro Ile Thr Lys  Leu Ser Val Asp His  Glu Leu Ile 
        995                 1000                 1005             


Lys Tyr  Gln Thr Thr Arg Ile  Ser Ile Phe Glu Met  Thr Leu Gly 
    1010                 1015                 1020             


Leu Glu  Lys Lys Leu Ile Asp  Lys Tyr Ser Thr Leu  Pro Thr Asp 
    1025                 1030                 1035             


Ser Phe  Arg Asn Met Leu Glu  Arg Trp Leu Gln Cys  Lys Ala Asn 
    1040                 1045                 1050             


Arg Pro  Glu Leu Lys Asn Cys  Val Asn Ser Leu Ile  Ala Val Arg 
    1055                 1060                 1065             


Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met Tyr Asp  Ala Thr Leu 
    1070                 1075                 1080             


Phe Ala  Glu Val Lys Lys Phe  Thr Leu Phe Pro Ser  Val Asp Thr 
    1085                 1090                 1095             


Lys Lys  Ile Glu Leu Asn Ile  Ala Pro Gln Leu Leu  Glu Ile Val 
    1100                 1105                 1110             


Gly Lys  Ala Ile Lys Glu Ile  Glu Lys Ser Glu Asn  Lys Asn 
    1115                 1120                 1125         


<210>  2605
<211>  1091
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2605

Met Asn Asn Lys His Val Phe Ala Ala Tyr Leu Asn Gln Ala Thr His 
1               5                   10                  15      


Asn Tyr His Leu Leu Leu Asn Asp Ile Ser Gln Lys Ile Gly Lys Thr 
            20                  25                  30          


Met Leu Glu Asp Glu Asn Leu Gln Val His Pro Val Ile Ser Leu Leu 
        35                  40                  45              


Ala Asp Ser Lys Asp Ala Arg Leu Ser Leu Arg Ala Ile Asn Ser Phe 
    50                  55                  60                  


Asn Lys Gly Phe Gly Phe Ile Glu Lys Leu Gln Arg Arg Ile Met Ala 
65                  70                  75                  80  


Tyr Arg Tyr Leu Ser Ala Lys Lys Ser Glu Pro Glu Asp Asn Ala Lys 
                85                  90                  95      


Pro Lys Lys His Ile Lys Lys Ser Gln Glu Tyr Ser Leu Leu Pro Ala 
            100                 105                 110         


Asp Tyr Ala Tyr Gln Leu Lys Ser Leu Ala Ser Thr Leu Asn Asp Glu 
        115                 120                 125             


Arg Asn His Ala Thr His Ala Tyr Leu Gln Pro Val Lys Pro Asp Ala 
    130                 135                 140                 


Asn Leu Ile Glu Phe Leu Tyr Asp Ile Phe Asp Met Ala Val Arg Val 
145                 150                 155                 160 


Cys Lys Ile Arg His Gln Ile Asp Glu Asn Asp Leu Lys His Leu Arg 
                165                 170                 175     


Arg Lys Met Arg Asn Pro Asp Lys Ser Lys Asp Ala Pro Lys Ser Ile 
            180                 185                 190         


Phe Asp Pro Lys Phe Lys Tyr Pro Phe Leu Asp Lys Gln Gly Gln Phe 
        195                 200                 205             


Thr Asp His Gly Arg Ala Phe Leu Thr Cys Leu Phe Leu Asn Lys Gln 
    210                 215                 220                 


Asp Ser Tyr Gln Phe Leu Lys Gln Leu Ser Gly Phe Lys Ser Ser Asn 
225                 230                 235                 240 


Ser Asn Thr His Lys Ala Thr Leu Arg Val Phe Ser Cys Phe Ser Ile 
                245                 250                 255     


Arg Leu Pro Asn Glu Arg Ile Asn Ser Thr Thr Asp Ala Gln Thr Leu 
            260                 265                 270         


Gly Leu Asp Met Leu Asn Glu Leu Ala Arg Cys Pro Ser Leu Leu Phe 
        275                 280                 285             


Pro Val Leu Pro Lys Ile Glu Lys Thr Ile Tyr Glu Ile Pro Val Glu 
    290                 295                 300                 


Val Asn Glu Gln Asn Asn Ser Asp Asp Gly Asn Asp Leu Leu Phe Ile 
305                 310                 315                 320 


Arg His Asp Glu Arg Phe Ile Ser Leu Met Met Arg Tyr Phe Asp Glu 
                325                 330                 335     


Thr Asn Ala Phe Glu Lys Leu Arg Phe His Ile Asp Leu Gly Asp Phe 
            340                 345                 350         


Tyr Phe Ala Ala Tyr Leu Lys Thr Leu Tyr Glu Asp Val Gln Asp Thr 
        355                 360                 365             


Arg Arg Leu Lys Gln Lys Leu His Thr Phe Ala Arg Leu Asn Glu Val 
    370                 375                 380                 


Glu Asn Thr Ala Ile Pro Ala Glu Trp Gln Thr Leu Ile Arg Asp Asn 
385                 390                 395                 400 


Arg Glu Ile Thr Glu Thr Asp Leu Asn Pro Tyr Leu Val Asn Thr Thr 
                405                 410                 415     


Pro His Tyr His Leu Leu Asp Asp Asn Ile Ala Leu Lys Ile Val Gly 
            420                 425                 430         


Pro Asn Thr Val Ile Tyr Pro Lys Leu Thr Pro His Asp Ser Ile Glu 
        435                 440                 445             


Asn Arg Tyr Lys Ser Pro Glu Asn Gln Gln Pro Asp Phe Trp Leu Ser 
    450                 455                 460                 


Lys His Glu Met Leu His Leu Ala Phe Tyr Gln Leu Leu Arg Gln Lys 
465                 470                 475                 480 


His Thr Gln Leu Asn Arg Gly Gln Ile Glu Asp Thr Val Phe Ala Gln 
                485                 490                 495     


Tyr Lys Gln Ala Leu His His Cys Leu Asp Gln Leu Ala Glu Asn Pro 
            500                 505                 510         


Glu Arg Tyr Thr Ser Lys Glu Ala Ile His Asp Leu Ala Gln Gln Tyr 
        515                 520                 525             


Thr Tyr Ser Pro Leu Lys Gln Ala Met Met Leu Asp Glu Ile Pro Lys 
    530                 535                 540                 


Val Val Arg Asp Ala Leu Ile Lys Lys Asp Ser Arg Tyr Gln Asn Ser 
545                 550                 555                 560 


Ala Leu Thr Ala Ile Ser Thr Leu Ile Asn Ile Gly Glu Lys Arg Leu 
                565                 570                 575     


Asp Ala Leu Lys Arg Ser Thr Ser Thr Asp Lys Lys Asp Lys Ser Thr 
            580                 585                 590         


Arg Pro Gly Asp Lys Lys Gln Arg Pro Val Lys Ala Gly Leu Met Gly 
        595                 600                 605             


Glu His Leu Ala Glu Asp Ile Val Arg Phe Gln Pro Ala Gln Asp Asp 
    610                 615                 620                 


Ser Asp Asn Lys Gly Lys Pro Thr Ser Leu Ile Val Ala Glu Leu Gln 
625                 630                 635                 640 


Ala Arg Leu Ala Phe Tyr Gly Arg Asp Lys Ala Gln Leu Pro Ala Leu 
                645                 650                 655     


Cys Lys Ala Met Lys Leu Ile Asp Asn Val Asp Thr Ser Lys Asn His 
            660                 665                 670         


Pro Phe Leu Ala Ala Val Leu Lys Glu Asn His Ala Gly Ile Ile Gly 
        675                 680                 685             


Phe Tyr Gln Ser Tyr Tyr Arg Ala Arg Ala His Tyr Leu Gln Arg Val 
    690                 695                 700                 


Glu Ala Asp Ile Thr Gln Asn Thr Ser His Ile Ser Arg Tyr His Trp 
705                 710                 715                 720 


Leu Lys Thr Pro Thr Arg Asp Lys Pro Asp Phe Ser Ile Lys Ser His 
                725                 730                 735     


Val Lys Lys Leu Lys Ala Gln Pro Val Asn Leu Pro Arg Gly Leu Phe 
            740                 745                 750         


Leu Pro Tyr Ile Lys His Ala Leu Leu Gln Leu Asn His Asp Thr Leu 
        755                 760                 765             


Thr Pro Ala Ile Glu Lys Ser Ala Thr Leu Asn Thr Ser Tyr Leu Ile 
    770                 775                 780                 


Ala Leu Tyr Tyr Gln His Val Leu Gln Asp Lys Pro Gln Ala Val Tyr 
785                 790                 795                 800 


Glu Lys Pro Arg Glu Tyr Lys Ile Ile Ala Gln Thr Phe Asp Asn Arg 
                805                 810                 815     


Thr Asn Gln Phe Lys Pro Leu Pro Ala His Pro Thr Gln Thr Gln Gln 
            820                 825                 830         


Ala Tyr Gly Thr Thr Asn Ala Leu His Thr Lys Ile Lys Gln His Leu 
        835                 840                 845             


Gln Ala Lys Tyr Pro Asp Glu Asp Lys Thr Gln Gln Leu Ala Ala Tyr 
    850                 855                 860                 


Arg Lys Phe Glu Gln Tyr Glu Lys Asn Ile Arg Gln Ile Arg Thr Gln 
865                 870                 875                 880 


Asp Gln Val Leu Phe Leu Ala Cys Gln Gln Leu Leu Ala Leu Asn His 
                885                 890                 895     


Gly Leu Asn Gln Glu Ile Ser Gln Leu Lys Leu His Gln Leu Asp Lys 
            900                 905                 910         


Thr Leu Leu Asp Lys Gln Thr His Tyr Gln Leu His Ile His Gly Lys 
        915                 920                 925             


Thr Ile Ser Gln Ala Gln Ile Arg Ile Lys Lys Ile Gly Glu Phe Arg 
    930                 935                 940                 


Arg Phe Leu Lys Asp Arg Arg Leu Lys Gly Leu Leu Ser Tyr Tyr Gly 
945                 950                 955                 960 


Gln His Asp Ile Pro Arg Glu Val Ile Ala Lys Glu Leu Glu Glu Tyr 
                965                 970                 975     


Gln His Cys Arg Leu Lys Val Phe Glu Arg Leu His Ala Phe Glu Gln 
            980                 985                 990         


Phe Ser Tyr Gln His Phe Gly Leu  Asp Ala Gln Tyr Gln  Gly Ser Glu 
        995                 1000                 1005             


His Gly  Gln Leu Leu Ser Ala  Tyr Phe Lys Ala Asn  Pro Gln Ala 
    1010                 1015                 1020             


Asn His  Glu Ala Gln Met His  Cys Met Leu Val Leu  Arg Asn Ala 
    1025                 1030                 1035             


Phe Ala  His Asn Gln Tyr Pro  Met Pro Gln Ser Lys  Tyr Pro Leu 
    1040                 1045                 1050             


Ala Asn  Ala Met Leu Thr Gln  Ala Gln Gln His Leu  Thr Gln Ser 
    1055                 1060                 1065             


Gly Ala  Pro Gln Val Ala Gln  Tyr Leu Leu Gln Gln  Val Glu Ala 
    1070                 1075                 1080             


Phe Tyr  Pro Asn Pro Ile Thr  Thr 
    1085                 1090     


<210>  2606
<211>  1160
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2606

Met Glu Thr Gln Glu Gln Ile Ala Lys Asn Ile Tyr Tyr Ala His Asp 
1               5                   10                  15      


Ile Tyr Glu Asp Lys His Tyr Phe Gly Ala Phe Leu Asn Leu Ala Gln 
            20                  25                  30          


Asn Asn Ile Gly Gln Val Phe Ser Glu Phe Cys Thr Arg Leu Asn Glu 
        35                  40                  45              


Pro Lys Asp Glu Asn Val His Asn Ile Ile Ile Lys Tyr Phe Ser Asn 
    50                  55                  60                  


Asn Val Ser Tyr Ser Asp Trp Asp Lys Arg Ile Lys Ile Leu Lys Glu 
65                  70                  75                  80  


Tyr Leu Pro Val Ile Glu His Leu Asn Leu Pro Thr Ser Asp Asn Ile 
                85                  90                  95      


Phe Glu Glu Tyr Gln Ile Asn Glu Lys Glu Asn Lys Lys Arg Asp Tyr 
            100                 105                 110         


Phe Arg Lys Asn Phe Gln Ser Leu Ile Lys Ser Val Asn Asp Leu Arg 
        115                 120                 125             


Asn Phe Tyr Thr His Tyr Tyr His Pro Pro Val Val Ile Asp Glu Ser 
    130                 135                 140                 


Leu Phe Asp Phe Leu Asp Ser Leu Leu Leu Lys Thr Cys Leu Thr Val 
145                 150                 155                 160 


Arg Lys Lys Lys Met Lys Asn Asp Lys Thr Arg Gln Ile Leu Lys Lys 
                165                 170                 175     


Gly Ile Ile Ala Glu Trp Lys Val Leu Glu Glu Leu Lys Val Asn Glu 
            180                 185                 190         


Leu Lys Lys Asn Lys Glu Lys Asn Lys Trp Ile Asn Ile Asp Asp Lys 
        195                 200                 205             


Glu Gly Ile Arg Asn Ala Ile Leu Asn Asp Ser Phe His His Leu Ile 
    210                 215                 220                 


Phe Lys Asp Lys Asp Ser Phe Cys Leu Lys Asp Tyr His Lys Ala Lys 
225                 230                 235                 240 


Tyr Ser Lys Asn Ile Phe Ala Glu Asn Lys Ile Pro Ile Ser Lys Ser 
                245                 250                 255     


Gly Leu Val Phe Leu Leu Ser Leu Phe Leu Thr Lys Lys Glu Thr Glu 
            260                 265                 270         


Gln Leu Lys Ala Asn Ile Glu Gly Phe Lys Ala Lys Val Ile Gly Lys 
        275                 280                 285             


Glu Asp Glu Val Thr Lys Lys Asn Asn Ser Leu Lys Tyr Met Ala Thr 
    290                 295                 300                 


His Trp Val Phe Ser Tyr Leu Thr Tyr Lys Gly Leu Lys Arg Arg Val 
305                 310                 315                 320 


Ser Thr Ser Phe Asn Lys Val Thr Leu Leu Thr Gln Met Leu Asp Glu 
                325                 330                 335     


Leu Ser Lys Val Pro Asp Glu Val Tyr Gln Thr Phe Ser Ile Ser Asp 
            340                 345                 350         


Lys Asp Glu Phe Leu Glu Asp Ile Asn Glu Phe Val Gln Glu Ser Thr 
        355                 360                 365             


Gly Asp Asp Lys Ser Leu Ile Glu Ser Thr Val Val His Pro Val Ile 
    370                 375                 380                 


Arg Lys Arg Tyr Glu Asn Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu 
385                 390                 395                 400 


Asp Glu Tyr Ala Asn Phe Pro Thr Leu Lys Phe Gln Ile Phe Ala Gly 
                405                 410                 415     


Leu Phe Gln His Asp His Lys Thr Lys Asn Ile Gly Glu Ser Asn Tyr 
            420                 425                 430         


Ile Ser Asp Arg Gln Ile Lys Glu Lys Ile Asn Val Phe Gly Lys Leu 
        435                 440                 445             


Ser Lys Val Ala Lys Tyr Lys Ser Asp Tyr Phe Thr Glu Asn Glu Asn 
    450                 455                 460                 


Glu Asn Glu Trp His Leu Phe Pro Asn Pro Ser Tyr Asn Phe Val Gly 
465                 470                 475                 480 


Asn Asn Ile His Ile Tyr Phe Asp Met Tyr Arg Lys Gly Ala Glu Val 
                485                 490                 495     


Lys Ser Val Gln Glu Glu Ile Asn Ala Leu Arg Lys Ile Ile Asn Pro 
            500                 505                 510         


Lys Lys Asp Arg Val Asn Arg Lys Gly Lys Lys Glu Ile Ile Asp Met 
        515                 520                 525             


Ile Tyr Asn Lys Ser Ser Lys Ile Glu Tyr Asn Glu Pro Thr Ala Leu 
    530                 535                 540                 


Phe Ser Leu Asn Glu Leu Pro Ala Ile Leu Tyr Glu Phe Leu Ile Asn 
545                 550                 555                 560 


Lys Lys Thr Gly Glu Asp Leu Glu Asn Ile Leu Val Gln Lys Ile Val 
                565                 570                 575     


Glu Arg Tyr Lys Thr Ile Lys Asn Tyr Asn Thr Thr Gln Gln Leu Ser 
            580                 585                 590         


Asn Ser Phe Ile Thr Lys Lys Leu Arg Lys Ser Ser Leu Lys Gln Asp 
        595                 600                 605             


Gln Ile Asn Ile Glu Lys Leu Leu Arg Ser Ile Asn Lys Glu Ile Glu 
    610                 615                 620                 


Ile Asn Gly Glu Lys Leu Asn Leu Ile Lys Thr Asn Lys Glu Glu Thr 
625                 630                 635                 640 


Thr Lys Thr Asn Lys Gln Asp Lys Pro Glu Arg Lys Tyr Ile Phe Tyr 
                645                 650                 655     


Thr Asn Glu Leu Gly Gln Glu Ala Thr Trp Leu Ala Asn Asp Leu Val 
            660                 665                 670         


Arg Phe Met Pro Lys Phe Ala Lys Thr Asn Trp Lys Gly Tyr Gln His 
        675                 680                 685             


Ser Glu Leu Gln Arg Leu Leu Ala Phe Tyr Asp Arg His Lys Asn Glu 
    690                 695                 700                 


Ala Lys Thr Leu Leu Thr Thr Asn Trp Asp Leu Asn Ser Phe Pro Ile 
705                 710                 715                 720 


Trp Gly Ser Asp Ile Asn Glu Ala Phe Asp Lys Asp Lys Phe Asp Glu 
                725                 730                 735     


Phe Tyr Glu Glu Tyr Leu Lys Lys Arg Lys Lys Thr Leu Glu Gly Phe 
            740                 745                 750         


Ala Asn Thr Ile Glu Leu Asn Lys Asn Asp Pro Lys Leu Leu Lys Lys 
        755                 760                 765             


Val Leu Lys Glu Val Phe Ile Ala Phe Asp Lys Arg Leu Phe Val Ile 
    770                 775                 780                 


Ser Ser Ile Asp Lys Gln Lys Asn Glu Leu Leu Ala Lys Pro Ile Val 
785                 790                 795                 800 


Phe Pro Arg Gly Ile Phe Asp Asn Lys Pro Thr Phe Ile Leu Gly Gln 
                805                 810                 815     


Lys Val Glu Gln Ala Pro Ser Leu Tyr Ala Asp Trp Tyr Ser Tyr Cys 
            820                 825                 830         


Tyr Asp Lys Ser Leu Arg Phe Gln Lys Phe Tyr Asp Phe Asn Arg Glu 
        835                 840                 845             


Cys Thr Asp Ser Phe Glu Lys Tyr Glu Val Glu Asn Lys Glu Ser Lys 
    850                 855                 860                 


Leu Asn Lys Lys Asn Leu Ser Arg Gln Gln Lys Ile Asp Leu Phe Lys 
865                 870                 875                 880 


Lys Lys Gln Asp Leu Leu Ile Lys Lys Val Gln His Lys Asp Ile Phe 
                885                 890                 895     


Ile Lys His Met Ile Asp Tyr Leu Phe Phe Lys Val Phe Lys Lys Glu 
            900                 905                 910         


Ile Asp Ile Ser Leu Asn Glu Ile Tyr Gln Thr Lys Glu Glu Arg Leu 
        915                 920                 925             


Asn Asn Gln Ile Val Ala Ile Glu Gln Arg Asp Arg Glu Lys Gly Asp 
    930                 935                 940                 


Lys Ser Glu Asn Lys Leu Ile Asp Asn Phe Ile Trp Asn Lys Thr Ile 
945                 950                 955                 960 


Ser Met Ser Leu Leu Asn Gly Gln Ile Ile Glu Pro Asp Val Lys Leu 
                965                 970                 975     


Lys Asp Ile Gly Lys Phe Lys Lys Leu Glu Thr Asp Lys Lys Val His 
            980                 985                 990         


His Leu Leu Ser Tyr Asp Lys Thr  Lys Ile Trp Asn Lys  Leu Met Leu 
        995                 1000                 1005             


Glu Asp  Glu Leu Glu Asn Lys  Leu Asp Ser Tyr Glu  Arg Ile Arg 
    1010                 1015                 1020             


Arg Glu  Lys Leu Leu Lys Leu  Val Gln Leu Phe Glu  Lys Gly Ile 
    1025                 1030                 1035             


Ile Glu  Asn His Ser Glu Asn  Asn Asp Glu His Pro  Lys Glu Phe 
    1040                 1045                 1050             


Glu Lys  Asp Gly Lys Pro Asn  Phe Arg Lys Tyr Ile  Ala Lys Gly 
    1055                 1060                 1065             


Val Leu  Lys Lys Asn Thr Lys  Ile Ala Glu Ser Glu  Ile Asn Trp 
    1070                 1075                 1080             


Leu Ser  Asp Ile Lys Asp Met  Glu Thr Val Glu Ile  Ser Glu Val 
    1085                 1090                 1095             


Asn Ser  Lys Ser Val Ile Leu  Gln Lys Ala Tyr Thr  Leu Ile Leu 
    1100                 1105                 1110             


Leu Arg  Asn Lys Phe Gly His  Asn Gln Leu Pro Asp  Lys Asn Ala 
    1115                 1120                 1125             


Phe Asp  Met Met Gln Thr Leu  Tyr Lys Thr Ala Glu  Asn Glu Thr 
    1130                 1135                 1140             


Tyr Ser  Lys Tyr Phe Leu Arg  Val Thr Glu Gln Ile  Ile Asn Glu 
    1145                 1150                 1155             


Phe Ser  
    1160 


<210>  2607
<211>  1146
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2607

Met Glu Ser Ile Ile Gly Leu Gly Leu Ser Phe Asn Pro Tyr Lys Thr 
1               5                   10                  15      


Ala Asp Lys His Tyr Phe Gly Ser Phe Leu Asn Leu Ala Asp Asn Asn 
            20                  25                  30          


Leu Lys Ala Val Phe Ala Glu Phe Lys Glu Arg Ile Ser Asp Lys Ser 
        35                  40                  45              


Lys Asp Glu Asp Ile Ser Asn Leu Ile Glu Lys His Phe Ile Asp Asn 
    50                  55                  60                  


Met Ser Ile Val Asp Tyr Glu Lys Asn Ile Ser Ile Leu Asn Gly Tyr 
65                  70                  75                  80  


Leu Pro Ile Ile Asp Phe Leu Asp Asp Glu Leu Glu Asn Asn Leu Asn 
                85                  90                  95      


Thr Arg Val Lys Asn Phe Lys Lys Ser Phe Ile Ile Leu Ala Glu Ala 
            100                 105                 110         


Leu Glu Thr Leu Arg Asn Tyr Tyr Thr His Phe Tyr His Asp Pro Ile 
        115                 120                 125             


Thr Phe Gly Asp Asn Lys Glu Pro Leu Leu Glu Leu Leu Asp Glu Val 
    130                 135                 140                 


Leu Leu Lys Thr Ile Leu Asp Val Lys Lys Lys Tyr Leu Lys Thr Asp 
145                 150                 155                 160 


Lys Thr Lys Glu Ile Leu Lys Asp Ser Leu Arg Glu Glu Met Asp Leu 
                165                 170                 175     


Leu Val Ile Arg Lys Thr Asp Glu Leu Arg Glu Lys Lys Lys Thr Asn 
            180                 185                 190         


Pro Lys Phe Lys Phe Ser Thr Asp Pro Thr Gln Ile Arg Asn Ser Ile 
        195                 200                 205             


Phe Asn Asp Ala Phe Gln Gly Leu Leu Tyr Glu Asp Lys Glu Asn Asn 
    210                 215                 220                 


Gly Lys Thr Gln Val Ser Tyr Arg Ala Lys Thr Lys Leu Asn Pro Lys 
225                 230                 235                 240 


Asp Ile His Lys Gln Glu Glu Arg Asp Phe Glu Ile Pro Leu Ser Thr 
                245                 250                 255     


Ser Gly Ile Val Phe Leu Met Ser Leu Phe Leu Ser Lys Lys Glu Ile 
            260                 265                 270         


Glu Asp Phe Lys Ser Asn Ile Lys Gly Phe Lys Gly Lys Val Val Lys 
        275                 280                 285             


Asp Glu Asn His Asn Ser Leu Lys Tyr Met Ala Thr His Arg Val Tyr 
    290                 295                 300                 


Ser Ile Leu Ala Phe Lys Gly Leu Lys Tyr Arg Ile Lys Thr Asp Thr 
305                 310                 315                 320 


Phe Ser Lys Val Thr Leu Met Met Gln Met Ile Asp Glu Leu Ser Lys 
                325                 330                 335     


Val Pro Asp Cys Val Tyr Gln Asn Leu Ser Glu Thr Lys Gln Lys Asp 
            340                 345                 350         


Phe Ile Glu Asp Trp Asn Glu Tyr Leu Lys Asp Asn Glu Glu Asn Thr 
        355                 360                 365             


Glu Asn Leu Glu Asn Ser Arg Val Val His Pro Leu Ile Arg Lys Arg 
    370                 375                 380                 


Tyr Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe 
385                 390                 395                 400 


Ala Asn Phe Lys Thr Leu Lys Phe Gln Val Phe Met Gly Tyr Tyr Ile 
                405                 410                 415     


His Asp Gln Arg Thr Lys Thr Ile Gly Thr Thr Asn Ile Thr Thr Glu 
            420                 425                 430         


Arg Thr Val Lys Glu Lys Ile Asn Val Phe Gly Lys Leu Ser Lys Met 
        435                 440                 445             


Asp Asn Leu Lys Lys His Phe Phe Ser Gln Leu Ser Asp Glu Glu Asn 
    450                 455                 460                 


Thr Asp Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Phe Leu Thr Gln 
465                 470                 475                 480 


Ala Asp Asn Ser Pro Ala Asn Asn Ile Pro Ile Tyr Leu Glu Leu Lys 
                485                 490                 495     


Asn Gln Gln Ile Ile Lys Glu Lys Asp Asp Ile Lys Ala Glu Val Asn 
            500                 505                 510         


Asn Ser Gln Asn Arg Asn Pro Asn Lys Pro Ser Lys Arg Asp Leu Leu 
        515                 520                 525             


Asn Lys Ile Ser Asn Thr Asn Glu Asp Phe Tyr Gln Gly Asp Pro Thr 
    530                 535                 540                 


Ala Ile Leu Ser Leu Asn Glu Ile Pro Ala Leu Leu His Leu Phe Leu 
545                 550                 555                 560 


Val Gln Pro Asp Asn Lys Thr Gly Gln Gln Ile Glu Asn Ile Ile Arg 
                565                 570                 575     


Ile Lys Ile Glu Lys Gln Phe Asn Ser Ile Lys Asn Pro Ser Lys Asp 
            580                 585                 590         


Asp Lys Gly Val Pro Lys Ser Leu Phe Ala Asp Thr Asn Val Arg Val 
        595                 600                 605             


Asn Ala Ile Lys Leu Lys Lys Asp Leu Gly Glu Glu Leu Asp Met Leu 
    610                 615                 620                 


Asn Lys Lys Gln Ile Val Phe Lys Glu Asn Gln Lys Ala Ser Ser Asn 
625                 630                 635                 640 


Tyr Asp Glu Leu Leu Lys Lys His Gln Phe Thr Pro Lys Asn Lys Arg 
                645                 650                 655     


Pro Ala Leu Arg Lys Tyr Val Phe Tyr Asn Ser Glu Lys Gly Glu Glu 
            660                 665                 670         


Ala Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Lys Gly Phe 
        675                 680                 685             


Lys Thr Lys Trp Lys Gly Tyr Gln His Ser Glu Leu Gln Arg Lys Leu 
    690                 695                 700                 


Ala Phe Tyr Asp Arg His Thr Lys Gln Asp Ile Lys Glu Leu Leu Ser 
705                 710                 715                 720 


Gly Cys Glu Phe Asp His Phe Leu Leu Asp Ile Asn Ala Cys Phe Lys 
                725                 730                 735     


Glu Asp Asp Phe Glu Asp Phe Phe Ser Lys Tyr Leu Lys Asn Arg Ile 
            740                 745                 750         


Glu Thr Leu Asn Ile Ile Leu Lys Gln Leu His Asp Phe Lys Asn Glu 
        755                 760                 765             


Pro Thr Pro Leu Lys Gly Val Phe Lys Asn Cys Leu Lys Phe Leu Lys 
    770                 775                 780                 


Gln Lys Asn Tyr Val Thr Glu Asn Pro Glu Ile Ile Lys Lys Arg Ile 
785                 790                 795                 800 


Leu Ala Lys Pro Ala Phe Leu Pro Arg Gly Ile Phe Asp Glu Arg Pro 
                805                 810                 815     


Thr Met Lys Lys Gly Lys Asn Pro Leu Ile Asp Arg Asp Glu Phe Ala 
            820                 825                 830         


Lys Trp Phe Val Glu Tyr Leu Glu Asn Lys Asp Tyr Gln Lys Phe Tyr 
        835                 840                 845             


Asn Ser Glu Glu Tyr Arg Ile Arg Asp Ala Asp Phe Lys Lys Asn Ala 
    850                 855                 860                 


Val Ile Lys Lys Gln Lys Leu Lys Asp Phe Tyr Thr Leu Gln Met Val 
865                 870                 875                 880 


Asn Tyr Leu Leu Lys Glu Val Phe Gly Lys Asp Glu Met Asn Leu Gln 
                885                 890                 895     


Leu Ser Glu Leu Phe Gln Thr Arg Gln Glu Arg Leu Lys Leu Gln Gly 
            900                 905                 910         


Ile Ala Lys Lys Gln Met Asn Lys Glu Thr Gly Asp Ser Ser Glu Asn 
        915                 920                 925             


Thr Arg Asn Gln Thr Tyr Ile Trp Asn Lys Asp Val Pro Val Ser Phe 
    930                 935                 940                 


Phe Asn Gly Lys Val Thr Ile Asp Lys Val Lys Leu Lys Asn Ile Gly 
945                 950                 955                 960 


Lys Tyr Lys Arg Tyr Glu Arg Asp Glu Arg Val Lys Thr Phe Ile Gly 
                965                 970                 975     


Tyr Glu Val Asp Glu Lys Trp Met Met Tyr Leu Pro His Asn Trp Lys 
            980                 985                 990         


Asp Arg Tyr Ser Val Lys Pro Ile  Asn Val Ile Asp Leu  Gln Ile Gln 
        995                 1000                 1005             


Glu Tyr  Glu Glu Ile Arg Ser  His Glu Leu Leu Lys  Glu Ile Gln 
    1010                 1015                 1020             


Asn Leu  Glu Gln Tyr Ile Tyr  Asp His Thr Thr Asp  Lys Asn Thr 
    1025                 1030                 1035             


Leu Leu  Gln Asp Gly Asn Pro  Asn Phe Lys Met Tyr  Val Leu Asn 
    1040                 1045                 1050             


Gly Leu  Leu Thr Gly Ile Lys  Gln Val Asn Ile Ala  Asp Phe Ile 
    1055                 1060                 1065             


Val Leu  Lys Gln Asn Thr Asn  Phe Asp Lys Ile Asp  Phe Thr Gly 
    1070                 1075                 1080             


Ile Ala  Ser Cys Ser Glu Leu  Glu Lys Lys Thr Ile  Ile Leu Ile 
    1085                 1090                 1095             


Ala Ile  Arg Asn Lys Phe Ala  His Asn Gln Leu Pro  Asn Lys Thr 
    1100                 1105                 1110             


Ile Tyr  Asp Leu Ala Asn Glu  Phe Leu Lys Lys Glu  Lys Arg Glu 
    1115                 1120                 1125             


Thr Tyr  Ala Asn Tyr Tyr Leu  Lys Val Leu Lys Lys  Met Ile Ser 
    1130                 1135                 1140             


Asp Leu  Ala 
    1145     


<210>  2608
<211>  1029
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2608

Met His Val Thr Thr Thr Asn Lys Pro Leu Leu Ala Ala Tyr Leu Asn 
1               5                   10                  15      


Met Ala Arg Asn Asn Cys Tyr Met Ala Leu Ser His Ile Ala Glu Leu 
            20                  25                  30          


Met Gly Lys Ser Ser Val Met Asn Glu Asp Ala Ile Gln Glu Cys Ala 
        35                  40                  45              


Val Ile Arg Ala Leu Ala Gly Asn Ile Lys Pro Asp Glu Ser Phe Arg 
    50                  55                  60                  


Ile Ile Asp Met Val Asp Gln His Phe Pro Phe Ile Arg Leu Leu Leu 
65                  70                  75                  80  


Lys Ser Arg Asn Asn Ser Ser Pro Thr Asp Tyr Ala Asn Cys Leu Thr 
                85                  90                  95      


Asp Phe Ile Lys Gln Leu Asn Glu Leu Arg Asn Phe His Thr His Gln 
            100                 105                 110         


Leu His Lys Pro Tyr Ile Thr Asp Ala Lys Val Val Ala Gln Leu Gln 
        115                 120                 125             


Phe Leu Phe Asp Ala Ser Arg Arg Glu Val Lys Lys Arg Phe Ser Leu 
    130                 135                 140                 


Glu Glu Gln Asp Val Lys His Leu Val Arg Lys Ser Ile Val Ile Ile 
145                 150                 155                 160 


Asp Asn Asn Lys Val Ala Val Glu Lys Glu Asn Tyr Val Tyr Ala Phe 
                165                 170                 175     


Ala Asn Lys Glu Gly Gln Phe Thr Asn Lys Gly Ile Ala Phe Leu Ile 
            180                 185                 190         


Ser Leu Phe Ile Glu Lys Lys Tyr Ala Tyr Leu Phe Leu Lys Gln Leu 
        195                 200                 205             


Ser Gly Phe Lys Asn Ser Asn Thr Lys Gln His Lys Ala Thr Leu Glu 
    210                 215                 220                 


Val Phe Cys Phe Tyr His Ile Arg Ile Pro Gln Pro Lys Leu Gln Ser 
225                 230                 235                 240 


Asn Asn Thr Lys Ile Gly Phe Leu Leu Asp Ala Leu Glu Glu Leu Lys 
                245                 250                 255     


Arg Cys Pro Ala Glu Leu Tyr Glu His Ile Ala Lys Asn Asp Lys Gln 
            260                 265                 270         


Arg Phe Lys Ser Ala Gly Ile Thr Glu Asp Thr Asn Asp Gln Pro Glu 
        275                 280                 285             


Ala Ile Leu Lys Arg Asn Gly Asp Arg Phe Ser Tyr Leu Ala Leu Arg 
    290                 295                 300                 


Tyr Leu Glu Leu Thr Asn Ser Leu Pro Gly Leu Gln Phe Tyr Phe Asp 
305                 310                 315                 320 


Leu Gly Lys Tyr Tyr Phe Lys Val Tyr Glu Lys Ser Ile Asp Ser Glu 
                325                 330                 335     


Leu Arg Leu Arg Arg Leu His Lys Asn Met Arg Asp Phe Gly Arg Thr 
            340                 345                 350         


Asn Asp Phe Asp Thr Val Lys Met Pro Gln Leu Trp Gln Gln Leu Ile 
        355                 360                 365             


Lys Arg Thr Asp Glu Leu Ser Glu Asn Tyr Ala Glu Pro Tyr Ile Val 
    370                 375                 380                 


Tyr Thr Ile Pro His Tyr His Ile Val Asn Asn Gln Ile Gly Ile Trp 
385                 390                 395                 400 


Leu Asn Lys Glu Arg Gln Met Pro Ser Leu Thr Pro Lys Ile Ser Asn 
                405                 410                 415     


Ala Glu Pro Gln Ile Trp Leu Ser Leu Tyr Glu Leu Pro Ala Leu Leu 
            420                 425                 430         


Phe Tyr His Leu Leu Thr Lys Gly Asn Lys Gly Gln Lys Asn Val Leu 
        435                 440                 445             


Gln Ile Leu Ser Lys His Arg Thr Ala Ile His Ser Phe Phe Lys Asp 
    450                 455                 460                 


Ile Glu Ser Ser Lys Leu Leu Pro Gly Phe Thr Ile Glu Thr Leu Asn 
465                 470                 475                 480 


Val Glu Leu Glu Lys Arg Asn Leu Lys His Asp Lys Ile Pro Lys Pro 
                485                 490                 495     


Leu Leu Gln Tyr Leu Leu Gln Gln Lys Pro Leu Lys Ser Ile Val Glu 
            500                 505                 510         


Ile Ala Gly Glu Arg Leu Ser Glu Leu Gln Asn Glu Thr Ile Phe Leu 
        515                 520                 525             


Leu Asp Lys Ile Asp Ile Asp Ile Glu Lys Ala Lys Glu Lys Ile Gly 
    530                 535                 540                 


Gly Lys His Tyr Arg Pro Ile Gln Thr Gly Lys Ile Ala Asp Phe Leu 
545                 550                 555                 560 


Ala Arg Asp Met Leu Phe Phe Gln Pro Ala Ile Asp Lys Ile Lys Gly 
                565                 570                 575     


Lys Ala Thr Ser Thr Leu Phe Gln Val Leu Gln Ala Arg Leu Ala Phe 
            580                 585                 590         


Tyr Gly Arg Asp Lys Glu Leu Leu Glu Gly Leu Tyr Lys Glu Cys Asn 
        595                 600                 605             


Leu Ile Gln Ser Lys Asn Pro His Pro Phe Leu Ser Gly Leu Pro Ile 
    610                 615                 620                 


Thr Asn Asn Leu Met Asp Tyr Tyr Arg Asn Tyr Leu Ile Lys Arg Asn 
625                 630                 635                 640 


Gln Tyr Leu Asp Lys Cys Leu Lys Lys Cys Lys Gln Gly Lys Ile Gly 
                645                 650                 655     


Ser Gln Asp Phe His Phe Leu His Leu Gly Glu Arg Glu Arg Lys Asn 
            660                 665                 670         


Gly Asn Thr Tyr Tyr Thr Asn Leu Ala Gly Lys Phe Ile Lys Met Pro 
        675                 680                 685             


Leu Asn Phe Pro Arg Gly Leu Phe Met Glu Glu Leu Ile Asn Tyr Phe 
    690                 695                 700                 


Glu Ser Ser Gly Asp Leu His Met Gln Asn Ile Ile Lys Asn Thr Pro 
705                 710                 715                 720 


Arg Leu Ser Thr Thr Phe Leu Leu Lys Glu Tyr Ile Asn Asn Val Leu 
                725                 730                 735     


Ser Asp Asp Thr Pro Asp Phe Tyr Asn Trp Lys Arg Ser Tyr Thr Val 
            740                 745                 750         


Phe Asn Arg Tyr Tyr Asp Lys Arg Lys Gln Asn Ser Arg Asp Ala Ile 
        755                 760                 765             


Thr Lys Ile Tyr Phe Asp Thr Ser Gln Leu Ser Glu Glu Ala Asn Lys 
    770                 775                 780                 


Ile Lys Ala Ala Ile Lys Lys Ile Glu Lys Ser Asp Ile Lys Gly Ala 
785                 790                 795                 800 


Glu Ser Ile Lys Arg Asn Tyr Lys Phe Tyr Gly Asp Asn Glu Lys Gln 
                805                 810                 815     


Leu Arg Gln Ala Lys Ala Cys Asp Thr Ile Leu Phe Leu Ala Ile Arg 
            820                 825                 830         


Asp Leu Phe Pro Thr Ile Glu Ser Ser Val Phe Lys Gly Leu Ala Ile 
        835                 840                 845             


Glu Gln Phe Arg Leu Ser Asp Ile Leu Pro Asp Ala Glu Lys Gly Ile 
    850                 855                 860                 


Leu Ser Gln Ser Ile Glu Ile Arg Leu Pro Leu Tyr Asn Lys Phe Ile 
865                 870                 875                 880 


Ile Gln Lys Gly Leu Lys Leu Lys Asn Tyr Gly Asp Phe Arg Arg Phe 
                885                 890                 895     


Leu Lys Asp Arg Arg Leu Glu Ser Leu Met Pro Tyr Phe Glu Glu Asp 
            900                 905                 910         


Asp Ile Asp Arg Ser Ser Leu Glu Lys Glu Leu Glu Asp Tyr Asp Thr 
        915                 920                 925             


Ala Arg Ile Glu Ile His Arg Val Val Leu Asp Phe Glu Ser His Val 
    930                 935                 940                 


Ile Thr Met Tyr Gln Leu Asn Tyr Leu Asn Pro Glu Asp Pro Cys Ile 
945                 950                 955                 960 


Asn His Glu Thr Ile Leu Asn Cys Phe Phe Gln Asn Asp Pro Ser Asp 
                965                 970                 975     


Ile Arg Lys Gln Leu Met Glu Asn Ile Arg Asn Arg Phe Ser His Asn 
            980                 985                 990         


Glu Tyr Pro Asp Phe Glu Lys Phe  Lys Glu Ile Ile Gln  Glu Asn His 
        995                 1000                 1005             


Gln Gln  Lys Thr Ile Ala Gly  Lys Phe Val Thr Leu  Ala Asn Gln 
    1010                 1015                 1020             


Tyr Phe  Ser Val Glu Glu 
    1025                 


<210>  2609
<211>  1131
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2609

Met Glu Lys Thr Ile Glu Asn Gln Thr Gln Ser Lys Arg Thr Leu Asn 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Asp Glu Glu Lys Ile Thr Thr Ser Phe Leu Val Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Arg Gln Ser Leu Val Tyr Ser Asn Leu Thr 
65                  70                  75                  80  


Arg Tyr Met His Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Asp 
                85                  90                  95      


Asp Glu Arg Asp Lys Ala Glu Asn Tyr Gly Lys Asp Phe Gly Asn Leu 
            100                 105                 110         


Thr Asp Thr Leu Lys Glu Ile Phe Lys Glu Leu Asn Glu Phe Arg Asn 
        115                 120                 125             


Asp Tyr Ser His Tyr Tyr Ser Thr Glu Lys Lys Asp Lys Arg Lys Thr 
    130                 135                 140                 


Ile Val Ser Asp Lys Leu Lys Asn Phe Leu Asn Ile Asn Tyr Thr Arg 
145                 150                 155                 160 


Ala Ile Lys Tyr Thr Lys Ser Arg Phe Ile Asn Val Phe Ser Asp Asn 
                165                 170                 175     


Asn Phe Cys Leu Ala Glu Glu Ala Lys His Val Glu Asn Asp Asn Thr 
            180                 185                 190         


Ile Thr Gln Asp Gly Ile Val Phe Phe Thr Ser Met Phe Leu Asp Arg 
        195                 200                 205             


Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile Ile Gly Leu Lys Gly Thr 
    210                 215                 220                 


Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Thr Leu Met Ala Phe Cys 
225                 230                 235                 240 


Val Asn Leu Pro His Asp Lys Phe Val Ser Glu Asn Ser Glu Gln Gln 
                245                 250                 255     


Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu 
            260                 265                 270         


Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln His Phe Leu Pro Lys Leu 
        275                 280                 285             


Asp Asp Glu Gln Ile Asp Asn Val Leu Glu Asn Ser Val Pro Tyr Thr 
    290                 295                 300                 


Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn Ile Thr Lys Lys Val Arg 
305                 310                 315                 320 


Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu Lys Phe Ile Asp Gln Lys 
                325                 330                 335     


Lys Leu Phe Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val 
            340                 345                 350         


Leu Asp Glu Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Lys Arg Thr 
        355                 360                 365             


Val Thr Glu Asn Thr Lys Ala Phe Gly Met Leu Gln Asp Leu Asn Asp 
    370                 375                 380                 


Glu Glu Asn Val Leu Asn Lys Ile Asn Thr Gly Glu Ser Lys Ala Lys 
385                 390                 395                 400 


Phe Asp Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Thr Lys Asn 
            420                 425                 430         


Thr Asp Asn Lys Ile Lys Ser Asn Leu Leu Gln Pro Leu Pro Glu Ala 
        435                 440                 445             


Phe Leu Ser Ile Asn Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
    450                 455                 460                 


Glu Gln Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn 
465                 470                 475                 480 


Asn Ser Lys Ile Leu Asn Lys Glu Phe Ile Lys Ala Ile Lys Leu Lys 
                485                 490                 495     


Leu Asn Asp Leu Asp Val Phe Tyr Lys Arg Ser Gln Gly Arg Lys Gln 
            500                 505                 510         


Lys His Ala Tyr Leu Thr Lys Asp Lys Lys Tyr Asp Asn Glu Lys Ile 
        515                 520                 525             


Asn Glu Leu Lys Asn Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu 
    530                 535                 540                 


Tyr Asn Leu Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp 
545                 550                 555                 560 


Leu Asn Ile Ala Asp Val Gln Ala Lys Asn Ala Ile Ser Asp Arg Ile 
                565                 570                 575     


Lys Leu Met Lys Arg Asp Cys Ile Asn Arg Leu Lys Ser Met Lys Lys 
            580                 585                 590         


Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp 
        595                 600                 605             


Ile Val Asp Met Ile Ile Asp Glu Glu Lys Lys Lys Lys Ile Thr Ser 
    610                 615                 620                 


Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Lys 
625                 630                 635                 640 


Glu Lys Lys Glu Leu Phe Ile Leu Ile Cys Asn Asn Glu Leu Lys Leu 
                645                 650                 655     


Asn Asp Asp Asp Gly His Pro Phe Phe Lys Asn Ile Asn Phe Ser Asn 
            660                 665                 670         


Tyr Lys Tyr Thr Ser Glu Ile Tyr Gln Lys Tyr Leu Glu Glu Lys Gly 
        675                 680                 685             


His Lys Met Val Lys Glu Tyr Asn Pro Arg Lys Glu Asn Tyr Val Glu 
    690                 695                 700                 


Lys Asp Lys Ser Trp Leu Glu Ile Asn Phe Tyr Lys Lys Glu Trp Asn 
705                 710                 715                 720 


Glu Asn Ala Lys Lys Asp Leu Thr Val Val Lys Leu Pro Asp Asp Lys 
                725                 730                 735     


Ser Lys Ile Pro Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser 
            740                 745                 750         


Phe Glu Asn Trp Phe Lys Tyr Val Thr Asn Gly Lys Glu Thr Thr Asp 
        755                 760                 765             


Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp Glu Thr Leu 
    770                 775                 780                 


Lys Glu Leu Leu Lys Lys Glu Leu Ser Lys Asn Asn Ile Glu Phe Lys 
785                 790                 795                 800 


Glu Glu Asp Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Asp Lys Cys 
                805                 810                 815     


Arg Asn Asp Lys Thr Gln Lys Phe Tyr Ser Ala Glu Arg Glu Tyr Thr 
            820                 825                 830         


Phe Glu Glu Glu Lys Leu Asn Phe His Ile Asn Thr Lys Ser Lys Phe 
        835                 840                 845             


Glu Glu Tyr Ile Asn Pro Glu Phe Ala Glu Lys Val Phe Arg Leu Lys 
    850                 855                 860                 


Asn Gln Asn Arg Glu Lys Asp Asn Ile Ser Gly Arg Arg Leu Pro Pro 
865                 870                 875                 880 


Leu Lys Met Lys Glu Val Thr Lys Asn Met Val Lys Arg Ile Gly Asn 
                885                 890                 895     


Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Leu Met Leu 
            900                 905                 910         


Leu Met Phe Glu Lys Leu Val Asp Asn Asn Leu Lys Leu Lys Leu Glu 
        915                 920                 925             


Asn Val Asp Lys Leu Leu Asn Glu Ser Ile Glu Ile Asn Gln Ser Ile 
    930                 935                 940                 


Ser Gly Lys Leu Ser Phe Asp Asp Ser Gly Asp Asn Glu Asn Lys Lys 
945                 950                 955                 960 


Asp Arg Ala Ile Ile Cys Arg Asn Ile Thr Glu Thr Arg Lys Arg Lys 
                965                 970                 975     


Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Glu Glu Glu  Asn Ile Pro Ile Glu  Lys Ile Lys 
        995                 1000                 1005             


Ile Glu  Leu Asp Thr Tyr Ser  Lys Ala Lys Asp Val  Val Phe Asp 
    1010                 1015                 1020             


Leu Ile  Phe Asp Leu Glu Arg  Ala Ile Ile Asn Lys  Asp Glu Asn 
    1025                 1030                 1035             


Arg Ile  Lys Glu Leu Asn Lys  Asp Lys Asn Gly Val  Ile Gln Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Phe Trp Leu  Leu Glu Lys 
    1055                 1060                 1065             


Asn Leu  Ile Thr Glu Gln Glu  Phe Thr Phe Met Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Thr  Phe Ser His Asn Gln  Phe Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Leu Phe  Ile Lys Asn Trp Asn  Glu Asn Glu Phe Ala  Lys Gln Ile 
    1100                 1105                 1110             


Leu Asn  Val Tyr Asn Gln Lys  Asn Asn Asn Leu Ile  Lys Ser Ile 
    1115                 1120                 1125             


Lys Asp  Ile 
    1130     


<210>  2610
<211>  1131
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2610

Met Glu Lys Thr Ile Glu Asn Gln Thr Gln Ser Lys Arg Thr Leu Asn 
1               5                   10                  15      


Asn Thr Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Asp Glu Glu Lys Ile Thr Thr Ser Phe Leu Val Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Arg Gln Ser Leu Val Tyr Ser Asn Leu Thr 
65                  70                  75                  80  


Arg Tyr Met His Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Asp 
                85                  90                  95      


Asp Glu Arg Asp Lys Ala Glu Asn Tyr Gly Lys Asp Phe Gly Asn Leu 
            100                 105                 110         


Thr Asp Thr Leu Lys Glu Ile Phe Lys Glu Leu Asn Glu Phe Arg Asn 
        115                 120                 125             


Asp Tyr Ser His Tyr Tyr Ser Thr Glu Lys Lys Asp Lys Arg Lys Thr 
    130                 135                 140                 


Ile Val Ser Asp Lys Leu Lys Asn Phe Leu Asn Ile Asn Tyr Thr Arg 
145                 150                 155                 160 


Ala Ile Lys Tyr Thr Lys Ser Arg Phe Ile Asn Val Phe Ser Asp Asn 
                165                 170                 175     


Asn Phe Cys Leu Ala Glu Glu Ala Lys His Val Glu Asn Asp Asn Thr 
            180                 185                 190         


Ile Thr Gln Asp Gly Ile Val Phe Phe Thr Ser Met Phe Leu Asp Arg 
        195                 200                 205             


Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile Ile Gly Leu Lys Gly Thr 
    210                 215                 220                 


Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Thr Leu Met Ala Phe Cys 
225                 230                 235                 240 


Val Asn Leu Pro His Asp Lys Phe Val Ser Glu Asn Ser Glu Gln Gln 
                245                 250                 255     


Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu 
            260                 265                 270         


Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln His Phe Leu Pro Lys Leu 
        275                 280                 285             


Asp Asp Glu Gln Ile Asp Asn Val Leu Glu Asn Ser Val Pro Tyr Thr 
    290                 295                 300                 


Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn Ile Thr Lys Lys Val Arg 
305                 310                 315                 320 


Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu Lys Phe Ile Asp Gln Lys 
                325                 330                 335     


Lys Leu Phe Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val 
            340                 345                 350         


Leu Asp Glu Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Lys Arg Thr 
        355                 360                 365             


Val Thr Glu Asn Thr Lys Ala Phe Gly Met Leu Gln Asp Leu Asn Asp 
    370                 375                 380                 


Glu Glu Asn Val Leu Asn Lys Ile Asn Thr Gly Glu Ser Lys Ala Lys 
385                 390                 395                 400 


Phe Asp Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Thr Lys Asn 
            420                 425                 430         


Thr Asp Asn Lys Ile Lys Ser Asn Leu Leu Gln Pro Leu Pro Glu Ala 
        435                 440                 445             


Phe Leu Ser Ile Asn Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
    450                 455                 460                 


Glu Gln Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn 
465                 470                 475                 480 


Asn Ser Lys Ile Leu Asn Lys Glu Phe Ile Lys Ala Ile Lys Leu Lys 
                485                 490                 495     


Leu Asn Asp Leu Asp Val Phe Tyr Lys Arg Ser Gln Gly Arg Lys Gln 
            500                 505                 510         


Lys His Ala Tyr Leu Thr Lys Asp Lys Lys Tyr Asp Asn Glu Lys Ile 
        515                 520                 525             


Asn Glu Leu Lys Asn Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu 
    530                 535                 540                 


Tyr Asn Leu Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp 
545                 550                 555                 560 


Leu Asn Ile Ala Asp Val Gln Ala Lys Asn Ala Ile Ser Asp Arg Ile 
                565                 570                 575     


Lys Leu Met Lys Arg Asp Cys Ile Asn Arg Leu Lys Ser Met Lys Lys 
            580                 585                 590         


Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp 
        595                 600                 605             


Ile Val Asp Met Ile Ile Asp Glu Glu Lys Lys Lys Lys Ile Thr Ser 
    610                 615                 620                 


Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Lys 
625                 630                 635                 640 


Glu Lys Lys Glu Leu Phe Ile Leu Ile Cys Asn Asn Glu Leu Lys Leu 
                645                 650                 655     


Asn Asp Asp Asp Gly His Pro Phe Phe Lys Asn Ile Asn Phe Ser Asn 
            660                 665                 670         


Tyr Lys Tyr Thr Ser Glu Ile Tyr Gln Lys Tyr Leu Glu Glu Lys Gly 
        675                 680                 685             


His Lys Met Val Lys Glu Tyr Asn Pro Arg Lys Glu Asn Tyr Val Glu 
    690                 695                 700                 


Lys Asp Lys Ser Trp Leu Glu Ile Asn Phe Tyr Lys Lys Glu Trp Asn 
705                 710                 715                 720 


Glu Asn Ala Lys Lys Asp Leu Thr Val Val Lys Leu Pro Asp Asp Lys 
                725                 730                 735     


Ser Lys Ile Pro Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser 
            740                 745                 750         


Phe Glu Asn Trp Phe Lys Tyr Val Thr Asn Gly Lys Glu Thr Thr Asp 
        755                 760                 765             


Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp Glu Thr Leu 
    770                 775                 780                 


Lys Glu Leu Leu Lys Lys Glu Leu Ser Lys Asn Asn Ile Glu Phe Lys 
785                 790                 795                 800 


Glu Glu Asp Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Asp Lys Cys 
                805                 810                 815     


Arg Asn Asp Lys Thr Gln Lys Phe Tyr Ser Ala Glu Arg Glu Tyr Thr 
            820                 825                 830         


Phe Glu Glu Glu Lys Leu Asn Phe His Ile Asn Thr Lys Ser Lys Phe 
        835                 840                 845             


Glu Glu Tyr Ile Asn Pro Glu Phe Ala Glu Lys Val Phe Arg Leu Lys 
    850                 855                 860                 


Asn Gln Asn Arg Glu Lys Asp Asn Ile Ser Gly Arg Arg Leu Pro Pro 
865                 870                 875                 880 


Leu Lys Met Lys Glu Val Thr Lys Asn Met Val Lys Arg Ile Gly Asn 
                885                 890                 895     


Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Leu Met Leu 
            900                 905                 910         


Leu Met Phe Glu Lys Leu Val Asp Asn Asn Leu Lys Leu Lys Leu Glu 
        915                 920                 925             


Asn Val Asp Lys Leu Leu Asn Glu Ser Ile Glu Ile Asn Gln Ser Ile 
    930                 935                 940                 


Ser Gly Lys Leu Ser Phe Asp Asp Ser Gly Asp Asn Glu Asn Lys Lys 
945                 950                 955                 960 


Asp Arg Ala Ile Ile Cys Arg Asn Ile Thr Glu Thr Arg Lys Arg Lys 
                965                 970                 975     


Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Glu Glu Glu  Asn Ile Pro Ile Glu  Lys Ile Lys 
        995                 1000                 1005             


Ile Glu  Leu Asp Thr Tyr Ser  Lys Ala Lys Asp Val  Val Phe Asp 
    1010                 1015                 1020             


Leu Ile  Phe Asp Leu Glu Arg  Ala Ile Ile Asn Lys  Asp Glu Asn 
    1025                 1030                 1035             


Arg Ile  Lys Glu Leu Asn Lys  Asp Lys Asn Gly Val  Ile Gln Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Phe Trp Leu  Leu Glu Lys 
    1055                 1060                 1065             


Asn Leu  Ile Thr Glu Gln Glu  Phe Thr Phe Met Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Thr  Phe Ser His Asn Gln  Phe Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Leu Phe  Ile Lys Asn Trp Asn  Glu Asn Glu Phe Ala  Lys Gln Ile 
    1100                 1105                 1110             


Leu Asn  Val Tyr Asn Gln Lys  Asn Asn Asn Leu Ile  Lys Ser Ile 
    1115                 1120                 1125             


Lys Asp  Ile 
    1130     


<210>  2611
<211>  1116
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2611

Met Glu Asn Thr Ile Glu Ile Gln Lys Gln Ser Ile Arg Thr Leu Asn 
1               5                   10                  15      


Asn Ala Pro Gln Tyr Phe Gly Leu Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn Tyr Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Glu Glu Glu Lys Ile Thr Ile Ser Phe Leu Gly Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Lys Gln Ser Tyr Ile Tyr Phe Asn Leu Ile 
65                  70                  75                  80  


Lys Tyr Met Pro Val Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Lys 
                85                  90                  95      


Asn Glu Ile Asp Lys Thr Lys Asn Asn Ser Gly Lys Asp Phe Asn Lys 
            100                 105                 110         


Leu Ser Asp Thr Leu Lys Val Ile Phe Lys Glu Leu Asn Glu Phe Arg 
        115                 120                 125             


Asn Asp Tyr Ser His Tyr Phe Ser Thr Glu Lys Gln Asp Lys Arg Lys 
    130                 135                 140                 


Leu Lys Ile Ser Ser Glu Leu Lys Asp Phe Leu Asn Ile Asn Phe Ser 
145                 150                 155                 160 


Arg Ala Leu Ser Tyr Thr Lys Asn Arg Leu Lys Asp Val Phe Ser Asp 
                165                 170                 175     


Asp Asp Phe Asn Ile Ala Ser Gln Thr Val Val Val Asn Asn Asp Asn 
            180                 185                 190         


Thr Ile Thr Gln Asp Gly Ile Val Phe Leu Ile Ser Met Phe Leu Asp 
        195                 200                 205             


Met Glu Asn Ala Phe Gln Phe Ile Asn Lys Ile Ile Gly Leu Lys Gly 
    210                 215                 220                 


Thr Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Val Leu Met Thr Phe 
225                 230                 235                 240 


Cys Val Lys Leu Pro His Asp Lys Phe Val Ser Glu Asn Pro Gln Gln 
                245                 250                 255     


Thr Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Leu 
            260                 265                 270         


Leu Tyr Asn Val Ile Thr Glu Glu Glu Lys Gln Ile Phe Lys Pro Gln 
        275                 280                 285             


Ile Gln Thr Glu Gln Ile Glu Asn Ile Ile Ser Asn Ser Val Pro Asp 
    290                 295                 300                 


Thr Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Ser Ile Thr Lys Lys Val 
305                 310                 315                 320 


Arg Tyr Glu Asn Arg Phe Ser Tyr Phe Ala Leu Lys Tyr Ile Asp Leu 
                325                 330                 335     


Lys Glu Leu Phe Lys Lys Trp Arg Phe Gln Ile Asp Leu Gly Lys Val 
            340                 345                 350         


Val Leu Asp Lys Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Val Arg 
        355                 360                 365             


Thr Val Thr Glu Asn Ala Lys Ala Phe Gly Arg Leu Gln Asp Phe Tyr 
    370                 375                 380                 


Asp Gln Glu Lys Ile Leu Asn Lys Ile Asn Ile Gly Glu Asn Lys Thr 
385                 390                 395                 400 


Arg Phe Tyr Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn 
                405                 410                 415     


Lys Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Ser Lys 
            420                 425                 430         


Asn Thr Thr His Lys Val Lys Phe Asn Leu Leu Gln Pro Leu Pro Glu 
        435                 440                 445             


Val Phe Leu Ser Ile His Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr 
    450                 455                 460                 


Leu Glu Gln Gly Lys Thr Glu Lys Leu Ile Asn Asn Phe Ile Lys Leu 
465                 470                 475                 480 


Ser Asn Ser Thr Ile Leu Asn Lys Lys Phe Ile Glu Thr Ile Lys Tyr 
                485                 490                 495     


Lys Leu Ser Asp Leu Asp Val Phe His Lys Arg Ser Met Gly Arg Lys 
            500                 505                 510         


Glu Ile Ser Ala Tyr Arg Lys Asp Ile Leu Lys Tyr Leu Ile Ala Arg 
        515                 520                 525             


Lys Glu Lys Leu Asn Gln Ile Leu Ser Glu His Asn Leu Ser Val Lys 
    530                 535                 540                 


Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp Leu Asn Ile Ala Asp Val 
545                 550                 555                 560 


Gln Glu Lys Thr Ala Ile Ser Asp Arg Ile Lys Leu Met Lys Arg Asp 
                565                 570                 575     


Cys Met Asp Arg Leu Lys Ala Ile Lys Lys Asn Asn Ala Pro Lys Ile 
            580                 585                 590         


Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile Val Asp Met Leu Ile 
        595                 600                 605             


Ser Glu Gly Lys Lys Lys Lys Ile Thr Ser Phe Tyr Tyr Asp Lys Met 
    610                 615                 620                 


Gln Glu Cys Leu Val Leu Phe Ala Asp Lys Glu Lys Lys Glu Leu Phe 
625                 630                 635                 640 


Ile Ser Ile Cys Ser Glu Leu Lys Leu Asn Asp Ala Asp Gly His Pro 
                645                 650                 655     


Phe Leu Lys Asn Ile Asn Leu Ser Asp Ile Arg Tyr Thr Ser Asp Leu 
            660                 665                 670         


Tyr Lys Ile Tyr Leu Gln Glu Lys Ala Asp Asn Arg Asn Gln Arg Asn 
        675                 680                 685             


Arg Thr Asp Thr Ser Trp Leu Ala Lys Asn Phe Tyr Thr Leu Lys Asn 
    690                 695                 700                 


Val Glu Val Phe Asp Lys Lys Gln Gln Arg Lys Ile Phe Lys Leu Gln 
705                 710                 715                 720 


Thr Ile Val Glu Leu Pro Gln Asp Lys Ser Lys Ile Pro Phe Thr Ile 
                725                 730                 735     


Arg Gln Leu Glu Lys Glu Lys Ser Ser Phe Asn Lys Trp Leu Glu Tyr 
            740                 745                 750         


Ile Thr Lys Gly Lys Glu Thr Thr Asp Lys Lys Lys Pro Val Asn Leu 
        755                 760                 765             


Pro Ala Asn Leu Phe Asp Asp Thr Leu Lys Lys Leu Leu Lys Thr Glu 
    770                 775                 780                 


Leu Ser Lys Asn Asn Ile Gln Tyr Asn Lys Glu Ala Asn Tyr Asn Gln 
785                 790                 795                 800 


Leu Phe Lys Ile Trp Trp Lys Glu Phe Arg Lys Asp Asn Thr Gln Asn 
                805                 810                 815     


Phe Tyr Thr Ala Glu Arg Glu Tyr Thr Phe Glu Glu Glu Lys Leu Asn 
            820                 825                 830         


Phe Lys Ile Asn Thr Gln Pro Lys Phe Glu Asn Tyr Tyr Thr Arg Phe 
        835                 840                 845             


Ala Glu Asn Val Phe Asn Lys Lys Gln Ala Leu Arg Asn Glu Glu Arg 
    850                 855                 860                 


Lys Thr Lys Arg Asn Leu Pro Pro Ile Gln Lys Ile His Val Ile Lys 
865                 870                 875                 880 


Lys Ile Arg Asn Lys Ile Gly Asn Thr Glu Lys Glu Ile Arg Met Leu 
                885                 890                 895     


Gln Glu Glu Asp Arg Leu Met Leu Leu Met Phe Glu Lys Leu Thr Lys 
            900                 905                 910         


Glu Asn Leu Asn Leu Lys Leu Glu Lys Val Asn Glu Leu Leu Asn Glu 
        915                 920                 925             


Arg Ile Glu Ile Lys Glu Lys Ile Pro Gly Lys Leu Ser Phe Asp Asp 
    930                 935                 940                 


Leu Gly Glu Lys Thr Ile Thr Arg Asn Ile Val Glu Thr Arg Lys Arg 
945                 950                 955                 960 


Lys Glu Tyr Ser Val Leu Gln Lys Tyr Ile Phe Asp Arg Arg Leu Pro 
                965                 970                 975     


Glu Leu Phe Glu Tyr Phe Asn Glu Thr Asp Ile Leu Ile Glu Lys Ile 
            980                 985                 990         


Lys Thr Glu Leu Asp Ala Tyr Asn  Lys Ala Lys Asp Ile  Val Phe Asp 
        995                 1000                 1005             


Leu Ile  Phe Lys Leu Glu Glu  Ala Ile Ile Lys Lys  Asp Glu Thr 
    1010                 1015                 1020             


Gly Ile  Lys Glu Leu Asn Lys  Asp Gln Asn Gly Asn  Ile Gln Thr 
    1025                 1030                 1035             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu His Trp Leu  Leu Lys Lys 
    1040                 1045                 1050             


Asn Met  Ile Thr Glu Lys Glu  Phe Thr Phe Ile Asn  Met Val Arg 
    1055                 1060                 1065             


Asn Thr  Phe Ser His Asn Arg  Phe Pro Gln Lys Lys  Thr Met Glu 
    1070                 1075                 1080             


Leu Phe  Ile Lys Lys Trp Asn  Asp Asn Asn Phe Ala  Tyr Gln Ile 
    1085                 1090                 1095             


Leu Glu  Thr Tyr Lys Gln Lys  Thr Asn Asn Ile Ile  Glu Lys Leu 
    1100                 1105                 1110             


Lys Asp  Met 
    1115     


<210>  2612
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2612

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2613
<211>  1146
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2613

Met Glu Ser Ile Ile Gly Leu Gly Leu Ser Phe Asn Pro Tyr Lys Thr 
1               5                   10                  15      


Ala Asp Lys His Tyr Phe Gly Ser Phe Leu Asn Leu Ala Asp Asn Asn 
            20                  25                  30          


Leu Lys Ala Val Phe Ala Glu Phe Lys Glu Arg Ile Ser Asp Lys Ser 
        35                  40                  45              


Lys Asp Glu Asp Ile Ser Asn Leu Ile Glu Lys His Phe Ile Asp Asn 
    50                  55                  60                  


Met Ser Ile Val Asp Tyr Glu Lys Asn Ile Ser Ile Leu Asn Gly Tyr 
65                  70                  75                  80  


Leu Pro Ile Ile Asp Phe Leu Asp Asp Glu Leu Glu Asn Asn Leu Asn 
                85                  90                  95      


Thr Arg Val Lys Asn Phe Lys Lys Ser Phe Ile Ile Leu Ala Glu Ala 
            100                 105                 110         


Leu Glu Thr Leu Arg Asn Tyr Tyr Thr His Phe Tyr His Asp Pro Ile 
        115                 120                 125             


Thr Phe Gly Asp Asn Lys Glu Pro Leu Leu Glu Leu Leu Asp Glu Val 
    130                 135                 140                 


Leu Leu Lys Thr Ile Leu Asp Val Lys Lys Lys Tyr Leu Lys Thr Asp 
145                 150                 155                 160 


Lys Thr Lys Glu Ile Leu Lys Asp Ser Leu Arg Glu Glu Met Asp Leu 
                165                 170                 175     


Leu Val Ile Arg Lys Thr Asp Glu Leu Arg Glu Lys Lys Lys Thr Asn 
            180                 185                 190         


Pro Lys Phe Lys Phe Ser Thr Asp Pro Thr Gln Ile Arg Asn Ser Ile 
        195                 200                 205             


Phe Asn Asp Ala Phe Gln Gly Leu Leu Tyr Glu Asp Lys Glu Asn Asn 
    210                 215                 220                 


Gly Lys Thr Gln Val Ser Tyr Arg Ala Lys Thr Lys Leu Asn Pro Lys 
225                 230                 235                 240 


Asp Ile His Lys Gln Glu Glu Arg Asp Phe Glu Ile Pro Leu Ser Thr 
                245                 250                 255     


Ser Gly Ile Val Phe Leu Met Ser Leu Phe Leu Ser Lys Lys Glu Ile 
            260                 265                 270         


Glu Asp Phe Lys Ser Asn Ile Lys Gly Phe Lys Gly Lys Val Val Lys 
        275                 280                 285             


Asp Glu Asn His Asn Ser Leu Lys Tyr Met Ala Thr His Arg Val Tyr 
    290                 295                 300                 


Ser Ile Leu Ala Phe Lys Gly Leu Lys Tyr Arg Ile Lys Thr Asp Thr 
305                 310                 315                 320 


Phe Ser Lys Val Thr Leu Met Met Gln Met Ile Asp Glu Leu Ser Lys 
                325                 330                 335     


Val Pro Asp Cys Val Tyr Gln Asn Leu Ser Glu Thr Lys Gln Lys Asp 
            340                 345                 350         


Phe Ile Glu Asp Trp Asn Glu Tyr Leu Lys Asp Asn Glu Glu Asn Thr 
        355                 360                 365             


Glu Asn Leu Glu Asn Ser Arg Val Val His Pro Leu Ile Arg Lys Arg 
    370                 375                 380                 


Tyr Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe 
385                 390                 395                 400 


Ala Asn Phe Lys Thr Leu Lys Phe Gln Val Phe Met Gly Tyr Tyr Ile 
                405                 410                 415     


His Asp Gln Arg Thr Lys Thr Ile Gly Thr Thr Asn Ile Thr Thr Glu 
            420                 425                 430         


Arg Thr Val Lys Glu Lys Ile Asn Val Phe Gly Lys Leu Ser Lys Met 
        435                 440                 445             


Asp Asn Leu Lys Lys His Phe Phe Ser Gln Leu Ser Asp Glu Glu Asn 
    450                 455                 460                 


Thr Asp Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Phe Leu Thr Gln 
465                 470                 475                 480 


Ala Asp Asn Ser Pro Ala Asn Asn Ile Pro Ile Tyr Leu Glu Leu Lys 
                485                 490                 495     


Asn Gln Gln Ile Ile Lys Glu Lys Asp Asp Ile Lys Ala Glu Val Asn 
            500                 505                 510         


Asn Ser Gln Asn Arg Asn Pro Asn Lys Pro Ser Lys Arg Asp Leu Leu 
        515                 520                 525             


Asn Lys Ile Ser Asn Thr Asn Glu Asp Phe Tyr Gln Gly Asp Pro Thr 
    530                 535                 540                 


Ala Ile Leu Ser Leu Asn Glu Ile Pro Ala Leu Leu His Leu Phe Leu 
545                 550                 555                 560 


Val Gln Pro Asp Asn Lys Thr Gly Gln Gln Ile Glu Asn Ile Ile Arg 
                565                 570                 575     


Ile Lys Ile Glu Lys Gln Phe Asn Ser Ile Lys Asn Pro Ser Lys Asp 
            580                 585                 590         


Asp Lys Gly Val Pro Lys Ser Leu Phe Ala Asp Thr Asn Val Arg Val 
        595                 600                 605             


Asn Ala Ile Lys Leu Lys Lys Asp Leu Gly Glu Glu Leu Asp Met Leu 
    610                 615                 620                 


Asn Lys Lys Gln Ile Val Phe Lys Glu Asn Gln Lys Ala Ser Ser Asn 
625                 630                 635                 640 


Tyr Asp Glu Leu Leu Lys Lys His Gln Phe Thr Pro Lys Asn Lys Arg 
                645                 650                 655     


Pro Ala Leu Arg Lys Tyr Val Phe Tyr Asn Ser Glu Lys Gly Glu Glu 
            660                 665                 670         


Ala Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Lys Gly Phe 
        675                 680                 685             


Lys Thr Lys Trp Lys Gly Tyr Gln His Ser Glu Leu Gln Arg Lys Leu 
    690                 695                 700                 


Ala Phe Tyr Asp Arg His Thr Lys Gln Asp Ile Lys Glu Leu Leu Ser 
705                 710                 715                 720 


Gly Cys Glu Phe Asp His Phe Leu Leu Asp Ile Asn Ala Cys Phe Lys 
                725                 730                 735     


Glu Asp Asp Phe Glu Asp Phe Phe Ser Lys Tyr Leu Lys Asn Arg Ile 
            740                 745                 750         


Glu Thr Leu Asn Ile Ile Leu Lys Gln Leu His Asp Phe Lys Asn Glu 
        755                 760                 765             


Pro Thr Pro Leu Lys Gly Val Phe Lys Asn Cys Leu Lys Phe Leu Lys 
    770                 775                 780                 


Gln Lys Asn Tyr Val Thr Glu Asn Pro Glu Ile Ile Lys Lys Arg Ile 
785                 790                 795                 800 


Leu Ala Lys Pro Ala Phe Leu Pro Arg Gly Ile Phe Asp Glu Arg Pro 
                805                 810                 815     


Thr Met Lys Lys Gly Lys Asn Pro Leu Ile Asp Arg Asp Glu Phe Ala 
            820                 825                 830         


Lys Trp Phe Val Glu Tyr Leu Glu Asn Lys Asp Tyr Gln Lys Phe Tyr 
        835                 840                 845             


Asn Ser Glu Glu Tyr Arg Ile Arg Asp Ala Asp Phe Lys Lys Asn Ala 
    850                 855                 860                 


Val Ile Lys Lys Gln Lys Leu Lys Asp Phe Tyr Thr Leu Gln Met Val 
865                 870                 875                 880 


Asn Tyr Leu Leu Lys Glu Val Phe Gly Lys Asp Glu Met Asn Leu Gln 
                885                 890                 895     


Leu Ser Glu Leu Phe Gln Thr Arg Gln Glu Arg Leu Lys Leu Gln Gly 
            900                 905                 910         


Ile Ala Lys Lys Gln Met Asn Lys Glu Thr Gly Asp Ser Ser Glu Asn 
        915                 920                 925             


Thr Arg Asn Gln Thr Tyr Ile Trp Asn Lys Asp Val Pro Val Ser Phe 
    930                 935                 940                 


Phe Asn Gly Lys Val Thr Ile Asp Lys Val Lys Leu Lys Asn Ile Gly 
945                 950                 955                 960 


Lys Tyr Lys Arg Tyr Glu Arg Asp Glu Arg Val Lys Thr Phe Ile Gly 
                965                 970                 975     


Tyr Glu Val Asp Glu Lys Trp Met Met Tyr Leu Pro His Asn Trp Lys 
            980                 985                 990         


Asp Arg Tyr Ser Val Lys Pro Ile  Asn Val Ile Asp Leu  Gln Ile Gln 
        995                 1000                 1005             


Glu Tyr  Glu Glu Ile Arg Ser  His Glu Leu Leu Lys  Glu Ile Gln 
    1010                 1015                 1020             


Asn Leu  Glu Gln Tyr Ile Tyr  Asp His Thr Thr Asp  Lys Asn Thr 
    1025                 1030                 1035             


Leu Leu  Gln Asp Gly Asn Pro  Asn Phe Lys Met Tyr  Val Leu Asn 
    1040                 1045                 1050             


Gly Leu  Leu Thr Gly Ile Lys  Gln Val Asn Ile Ala  Asp Phe Ile 
    1055                 1060                 1065             


Val Leu  Lys Gln Asn Thr Asn  Phe Asp Lys Ile Asp  Phe Thr Gly 
    1070                 1075                 1080             


Ile Ala  Ser Cys Ser Glu Leu  Glu Lys Lys Thr Ile  Ile Leu Ile 
    1085                 1090                 1095             


Ala Ile  Arg Asn Lys Phe Ala  His Asn Gln Leu Pro  Asn Lys Thr 
    1100                 1105                 1110             


Ile Tyr  Asp Leu Ala Asn Glu  Phe Leu Lys Lys Glu  Lys Arg Glu 
    1115                 1120                 1125             


Thr Tyr  Ala Asn Tyr Tyr Leu  Lys Val Leu Lys Lys  Met Ile Ser 
    1130                 1135                 1140             


Asp Leu  Ala 
    1145     


<210>  2614
<211>  967
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2614

Val Asp Ala Tyr Lys Glu Glu Ser Lys Gln Ala His Leu Phe Lys Asp 
1               5                   10                  15      


Asn Tyr Ile Thr Thr Glu Gly Arg Val Phe Phe Leu Ser Phe Phe Leu 
            20                  25                  30          


Thr Ser Gly Glu Met Ser Ser Phe Leu Gln Gln His Arg Gly Ser Lys 
        35                  40                  45              


Arg Thr Asp Glu Leu Lys Phe Arg Ile Lys His Ile Val Tyr Arg Tyr 
    50                  55                  60                  


Tyr Thr His Arg Asp Gly Ser Thr Arg Gln Lys Phe Ser Gln Glu Asp 
65                  70                  75                  80  


Asp Val Leu Ser Ser Phe Ser Pro Asn Asp Gln Gln Asp Val Leu Met 
                85                  90                  95      


Ala Arg Gln Ser Phe Lys Leu Arg Thr Tyr Leu Asn Asp Val Pro Asp 
            100                 105                 110         


Ser Ala Asn Asn Ile Asp Leu Tyr Pro Leu Phe Thr Asp Ser Gly Glu 
        115                 120                 125             


Arg Lys Pro Ala Glu Thr Ala Gln Glu Leu Lys Ala Phe Cys Asp Gln 
    130                 135                 140                 


Arg Glu Leu Phe Thr Thr Ile Gln Ile Thr Asp Val Ala Asn Lys Lys 
145                 150                 155                 160 


Gly Glu Ile Gln Thr Gly Val Leu Asn Phe Ser Ile Pro Ala Leu Gly 
                165                 170                 175     


Asp Thr Ala Val Arg Leu Gly Arg Gly Thr Phe His Lys Leu Ile Ile 
            180                 185                 190         


Asp Thr Leu Arg Arg His Asp Asn Gly Lys Phe Val Tyr Asp Gly Leu 
        195                 200                 205             


Thr Trp Leu Ile Thr Glu Arg Leu Lys Leu Ile Glu Glu Leu Gln Lys 
    210                 215                 220                 


Leu Asp Thr Leu Gln His Leu Asp Glu Thr Ser Gly Met Ala Gln Arg 
225                 230                 235                 240 


Lys Phe Phe Glu Glu Tyr Met Leu His Lys Leu Asn Gly Asn Leu Tyr 
                245                 250                 255     


Leu Gln Gln Leu Met Arg Asn Trp Phe Tyr Ala Phe Glu Lys Asp Leu 
            260                 265                 270         


Lys Lys Glu Gly Lys Leu Arg Asp Lys Leu Val Gln Gly Cys Ile Gln 
        275                 280                 285             


Asp Pro Val Ala Pro Gly Tyr Tyr Asp Phe Tyr Phe Glu Glu Gly Glu 
    290                 295                 300                 


Lys Pro Arg Asn Thr Asp Arg Phe Ser Glu Phe Ala Val Lys Tyr Leu 
305                 310                 315                 320 


Ile Asp Phe Asn Leu Ala Pro Asp Trp Glu Trp Met Met Glu Ser Phe 
                325                 330                 335     


Gly Val Ala Asp Lys His Gly Lys Ala Ile Ser Gly Lys Asn Lys Ala 
            340                 345                 350         


Phe Phe Ser His Phe Lys Ser Gly Thr Ala Trp Arg Leu Ser Val Thr 
        355                 360                 365             


Asp Gly Cys Val Ile Val Arg Leu Lys Arg Leu Pro Asp Phe Arg Phe 
    370                 375                 380                 


Gln Leu Gly His Arg Ala Leu Lys Asn Leu Leu Ile Ala His Phe Tyr 
385                 390                 395                 400 


Gln Lys Ala Asn Ile Gly Thr Leu Leu Asn Lys Leu Thr Lys Asp Thr 
                405                 410                 415     


Gln Lys Ile Arg Asn Val Leu Tyr Asn Lys Thr Ser His Thr Leu Thr 
            420                 425                 430         


Asp Leu Ala Leu Leu Glu Arg Lys Asn Leu Pro Arg Phe Val Leu Leu 
        435                 440                 445             


Thr Leu Gly Asp Ala Gln Thr Ala Ala Gly Glu Thr Val Glu Asn Ala 
    450                 455                 460                 


Thr Val Ala Thr Leu Lys Arg Ile Ser Asn Leu Ile Ala Lys Leu Arg 
465                 470                 475                 480 


Asp Trp Arg Thr Asn His Lys Thr Ile Ser Arg Asn Glu Lys Asn Arg 
                485                 490                 495     


Ile Ile Met Asp Cys Tyr Gln Leu Phe Asp Trp Lys Tyr Pro Asp Thr 
            500                 505                 510         


Gly Thr Tyr Lys Phe Leu Arg Arg Asp Glu Tyr Gln Asn Met Ser Ile 
        515                 520                 525             


Tyr His Tyr Met Leu Glu Arg Val Leu Asn Leu Arg Glu Asp Ile Thr 
    530                 535                 540                 


Tyr Phe Gln Gln Lys Ile Gln Asp Ala Glu Asp Tyr Gly Lys Lys Lys 
545                 550                 555                 560 


Lys Tyr Gln Met Ala Ile Phe Asp Asn Asn Lys Gln Ile Glu Arg Thr 
                565                 570                 575     


Glu Thr Ile Leu Ser Lys Leu Leu Lys Asp Val Lys Asn Arg Ile Pro 
            580                 585                 590         


Glu Glu Val Asn Gln Ile Leu Glu Asn Ser Glu Ser Leu Asp Asp Leu 
        595                 600                 605             


Leu Lys Asn Ala Thr Thr Asp Ala Ile Ile Lys Leu Ser Glu Trp Gln 
    610                 615                 620                 


Leu Glu Leu Glu Lys Gly Asn Asn Glu Leu Phe Glu Thr Val Arg Gln 
625                 630                 635                 640 


Lys Leu Gly Ile Pro Gln Pro Val Pro Val Val Asn Glu Ala Val Lys 
                645                 650                 655     


Leu Arg Trp Thr Asp Lys Gln Asn Gly His Phe Phe His Gln Val His 
            660                 665                 670         


Pro Ala Val Val Val His His Phe Phe Lys Ser Glu Ile Ser Asp Pro 
        675                 680                 685             


Ala Asn Ser Asn Ser Asn Gln Gly Phe Ser Leu Ser Lys Leu Ile Arg 
    690                 695                 700                 


Gly Asp Glu Ser Tyr Thr Gly Gly Leu Arg His Ala His Tyr Asn Tyr 
705                 710                 715                 720 


Lys Pro Tyr Leu Ala Thr Leu Asn Thr Gly Asn Ala Thr Glu Lys Ala 
                725                 730                 735     


Val Leu His Lys Ala Ile Arg Phe Asn Asn Thr Gln Leu Thr Glu Asp 
            740                 745                 750         


Ala Leu Leu Trp Lys Val Ala Gln Val Tyr Leu Gly Lys Val Asn Pro 
        755                 760                 765             


Val Val Lys Ser Val Leu Asp Ala Gln Leu Asn Lys Ser Gly Ile Leu 
    770                 775                 780                 


Lys Ile Glu Asn Leu His Ala Thr Glu Leu Pro Leu Gln Val Asn Ile 
785                 790                 795                 800 


Gly Asn Asp Thr Leu Thr Leu Ser Leu Arg Phe His Gln Leu Asp Asp 
                805                 810                 815     


Ile Leu Leu Phe Ala Ser Lys Ala Ala Leu Gln Lys Ala Ala Ala His 
            820                 825                 830         


Tyr Leu Asn Arg Ile Ser Pro Glu Glu Arg Ala Ala Leu Leu Thr Glu 
        835                 840                 845             


Pro Asn Thr Leu Pro Tyr Asn Glu Met Lys Gln Glu Met Met Arg Ile 
    850                 855                 860                 


Asn His Gln Ser Leu Glu Phe Ala His Tyr Ile Leu Asp Tyr Glu Arg 
865                 870                 875                 880 


Gly Ile Ile Asp Ala Ala Asp Glu Lys Thr Leu Pro Ala Lys Glu Glu 
                885                 890                 895     


Pro Phe Pro Ala Val Cys Lys Arg Ala Gln Leu Ser Asp Glu Gln Ser 
            900                 905                 910         


Ala Glu Leu Ile Leu Leu Arg Asn His Ala Phe His Asn Lys Ile Pro 
        915                 920                 925             


Met Gly Trp Asn Tyr Thr Gln Lys Arg Gln Thr Glu Trp Leu Arg Lys 
    930                 935                 940                 


Leu Leu Asn Ile Thr Glu Lys Glu Pro Val Asp Tyr Glu Ala Leu Ala 
945                 950                 955                 960 


Arg Glu Gln Lys Lys Asn Ile 
                965         


<210>  2615
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2615

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Met Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Met Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Val Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2616
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2616

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Thr 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2617
<211>  1124
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2617

Met Thr Leu Pro Ile Asn Asn Thr Phe Thr Ser Arg Ala Asp Arg Glu 
1               5                   10                  15      


Ile Leu Ser Gln Asn Lys Leu Phe Phe Gly Thr Tyr Leu Asn Met Ala 
            20                  25                  30          


Gln His Asn Thr Phe Leu Met Leu Thr Asp Ser Ser Glu Lys Val Gly 
        35                  40                  45              


Lys Thr Pro Pro Ser Ser Glu Gly Leu Trp Lys Asp Ala Gly Thr Phe 
    50                  55                  60                  


Ser Leu Leu Asn Thr Gln Gln Arg Pro Ser Ile Arg Ser Lys Ala Gly 
65                  70                  75                  80  


Arg Leu Ala Val Lys Gln Phe Val Ala Leu Glu Ser Leu Val Ile Glu 
                85                  90                  95      


Arg Glu Glu Gly Glu Ala Glu Thr Pro Pro Asp Val Glu Lys Leu His 
            100                 105                 110         


Asp Phe Leu Tyr Ser Ala Leu Glu Leu Leu Asn Asn Leu Arg Arg Glu 
        115                 120                 125             


Tyr Ser His Tyr Tyr His Glu Thr Ala Gln Asn Ile Asp Tyr Pro Lys 
    130                 135                 140                 


Leu Glu Ala Ile Phe Arg Glu Ala Lys Arg Val Ala Ile Glu Arg Leu 
145                 150                 155                 160 


Pro Lys Asp Asp Asp Lys Ala Lys Asn Lys Ala Glu Lys Lys Ile Val 
                165                 170                 175     


Lys Tyr Met Leu Arg Asn Glu Asp Glu Lys Leu Val Phe Phe Ile Ser 
            180                 185                 190         


Leu Phe Leu Ser Arg Gln Gln Ala Glu Ala Phe Met Ser Gln Ile Asn 
        195                 200                 205             


Asp Phe Lys Gly Glu His Asn Ala Leu Lys Arg Arg Val Phe Ala Gln 
    210                 215                 220                 


Leu Cys Cys Arg Leu Pro Arg Pro Lys Leu Glu Ser Ala Ala Leu Glu 
225                 230                 235                 240 


Leu Asp Ala Leu Asn Glu Leu Ala Arg Cys Pro Asp Glu Val Phe Arg 
                245                 250                 255     


Tyr Leu Asn Thr Glu Asp Lys Asn Arg Phe Val Val Pro Leu Lys Glu 
            260                 265                 270         


Leu Asp Lys Asp Asp Thr Ser Gly Asn Thr Ile Thr Leu Lys Arg Tyr 
        275                 280                 285             


Glu Asp Arg Leu Pro Tyr Leu Leu Met Arg Tyr Leu Asp Glu His Ala 
    290                 295                 300                 


Glu Asn Phe Gly Ile His Phe Gln Ile Trp Ala Gly Lys Leu Arg Thr 
305                 310                 315                 320 


Ala Asp Tyr Pro Lys Thr Ile Tyr Asp Ile Glu Asp Asn Arg Asn Ile 
                325                 330                 335     


His Glu Asn Leu Thr Ala Tyr Asp Thr Leu Gln Asn Leu Arg Asn Gly 
            340                 345                 350         


Asp Asn Ile Pro Asp Asn Trp Lys Met Gln Asp Gly Glu Leu Leu Thr 
        355                 360                 365             


Lys Ile Glu Gln Phe Ser Pro His Tyr Asn Ile Ile Asn Asn Arg Ile 
    370                 375                 380                 


Ala Leu Lys Leu Gly Asp Thr Ala Tyr Thr Glu Ile Tyr Pro Leu Ser 
385                 390                 395                 400 


Glu Asp Ser Lys Leu Asp Phe Arg Val Lys Asn Pro Leu Pro Asp Leu 
                405                 410                 415     


Ile Ile Ser Thr Tyr Asp Ile Pro Asn Leu Phe Leu Tyr Gln Tyr Leu 
            420                 425                 430         


His Gln Gln Gly Lys Ile Arg Leu Arg Pro Asp Ile Phe Ile Arg Gln 
        435                 440                 445             


Phe Ser Gly Lys Leu Arg Lys Val Phe Lys Asp Val Gln Ser Gly Glu 
    450                 455                 460                 


Leu Lys Pro Leu Gln Ala Glu Ala Phe Glu Lys Gln Gln Arg Tyr Ser 
465                 470                 475                 480 


Glu Arg Arg Gln Glu Ile Leu Glu Glu Arg Arg Ser Gln Leu Gln Ala 
                485                 490                 495     


Ile Leu Asp Asn Lys Tyr Lys Leu Val Lys Val Ser His Leu Pro Asp 
            500                 505                 510         


Ala Leu Arg Glu Tyr Leu Phe Asn Tyr Lys Ala Gln Asp Phe Asn Arg 
        515                 520                 525             


Gln Val Leu His Lys Ile Thr Glu Arg Met Glu Ala Asp Trp Gln Arg 
    530                 535                 540                 


Lys Lys Lys Ala Glu Tyr Gly Ser Gly Thr Asp Glu Pro Glu Leu Lys 
545                 550                 555                 560 


Ala Gly Asn Ile Gly Thr Tyr Ile Ala Arg Asp Ile Val Ala Leu Gln 
                565                 570                 575     


Pro Pro Asn Pro Gln Glu Val Asn Leu Gly Lys Pro Asn Asn Asp Gln 
            580                 585                 590         


Tyr Asn Glu Leu Gln Glu Ser Ile Ala Tyr Phe Gly Arg Glu Tyr His 
        595                 600                 605             


Val Leu Pro Ala Tyr Leu Arg Lys Glu Leu Gly Val Met Gly Glu Arg 
    610                 615                 620                 


Asn Asp Lys Thr Lys His Pro Phe Leu Val His Leu Asn Trp Asn Lys 
625                 630                 635                 640 


Cys His Thr Ala Lys Glu Phe Tyr Ile Glu Tyr Leu Asp Val Lys Arg 
                645                 650                 655     


Arg Trp Met Arg Ala Val Arg Asp Asp Ile Lys Ala Val Ser Pro Gln 
            660                 665                 670         


Thr Glu Gln Pro His Phe Val Lys Met Gln Arg Asn Ala Lys His Phe 
        675                 680                 685             


Gly Ile Asn Ile Asn Lys Ser Ala Leu Thr Asp Glu Gln Ile Gln Glu 
    690                 695                 700                 


Arg Tyr Gly Tyr Phe Leu Arg Ile Asn Ser Lys Ala Ala Lys Asp Arg 
705                 710                 715                 720 


Asn Tyr Leu Lys Thr Met Arg Lys Asn Pro Ile Ser Gly Asp Phe Glu 
                725                 730                 735     


Pro Thr Asp Asn Ala Pro Ile Met Leu Pro Arg Gly Ile Phe Asn Asp 
            740                 745                 750         


Ala Ile Arg Glu Ala Leu Arg Thr Asn Tyr Pro Asp Gln Ile Asn Asp 
        755                 760                 765             


Lys Ser Gly Met Ser Asp Phe Thr Arg Ile Met Ala Asn Asp Glu Asp 
    770                 775                 780                 


Leu Gln Thr Cys Tyr Ser Tyr Pro Arg His Tyr Arg Tyr Glu Ala Asp 
785                 790                 795                 800 


Asn Asp Lys Leu Phe Lys Asn Asp Arg Glu Lys Ala Arg His Thr Ile 
                805                 810                 815     


Asp Ile Lys Gly Asp Thr Ala Gln Ile Trp Gln Gly Leu Cys Asp Leu 
            820                 825                 830         


Lys Thr Glu Leu Lys Asp Asn Leu Thr Arg Ala Lys Asn Ser Gln Leu 
        835                 840                 845             


Lys Arg Leu Phe Glu Gln Val Asp Arg Gln Lys Lys Leu Trp Arg Arg 
    850                 855                 860                 


Ile Phe Arg Asn Glu Gln Ala Ile Arg Thr Val Ala Phe Lys Asp Arg 
865                 870                 875                 880 


Leu Val Trp Leu Met Val Lys Asp Ile Leu Thr Arg Lys Ser Gln Ala 
                885                 890                 895     


Glu Gln Ser Asn Leu Gln Leu Glu Gln Trp Gln Leu Gln Asp Thr Gly 
            900                 905                 910         


Phe Asp Val Arg Lys Thr Glu Val Trp Ile Leu Asp Gln Ala Ile Pro 
        915                 920                 925             


Thr Ser Leu Thr Ile His Asp Lys Asp Ile Cys Ala Asn Phe Gln Ser 
    930                 935                 940                 


Ala Glu Leu Asp Lys Ala Arg Glu Asn Glu Leu Pro Val Lys Arg Tyr 
945                 950                 955                 960 


Gly Glu Phe Arg Lys Met Leu Lys Asp Arg Arg Leu Phe Val Ala Asn 
                965                 970                 975     


Asn Ser Gly Leu Leu Arg Tyr Tyr Pro Glu Lys Ser Ile Leu Trp Thr 
            980                 985                 990         


Thr Leu Gln Asp Glu Leu Arg Asp  Tyr Asp Gln Cys Arg  Ala Glu Leu 
        995                 1000                 1005             


Leu Asn  Ala Ile Phe Ala Phe  Glu Gln Arg Val Leu  Ser Asn Gln 
    1010                 1015                 1020             


Gln Cys  Arg Gln His Leu Ser  Leu Thr Glu Asn Arg  Ile Asp His 
    1025                 1030                 1035             


Lys Val  Tyr Leu Glu Ala Tyr  Lys Ala Thr Tyr Gly  Asn Met Pro 
    1040                 1045                 1050             


Gln Pro  Ile Ser Asn Ile Asn  Gln Leu Arg Asn Lys  Phe Met His 
    1055                 1060                 1065             


Asn Gln  Ile Pro Tyr Asp Thr  Trp Ile Ser Gln Ala  Ile Glu His 
    1070                 1075                 1080             


Asn Thr  Asn Ala Asn Leu Pro  Ile Glu Asp His Arg  Asn Lys Asn 
    1085                 1090                 1095             


Val Val  Lys Gln Leu Ile Glu  Phe Ala Thr Glu Leu  Tyr Asp Gly 
    1100                 1105                 1110             


Met Asn  Glu Ile Leu Phe Tyr  Asn Lys Glu Asn 
    1115                 1120                 


<210>  2618
<211>  1097
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2618

Met Glu Tyr Thr Arg Tyr Lys Glu Trp Gly Lys Asp Leu Phe Tyr Phe 
1               5                   10                  15      


Asn His Phe Ala Asn Met Ala Arg His Asn Ala Phe Leu Ile Ile Asn 
            20                  25                  30          


Asp Ile Leu Asn Thr Val Tyr Lys Ala Glu Asp Gln Leu Thr Glu Glu 
        35                  40                  45              


Ser Leu Ser Asn Leu Tyr Lys Lys Val Leu Ala Lys Ser Lys Gly Arg 
    50                  55                  60                  


Pro Asp Glu Leu Ala Leu Leu Ser Ser Leu Leu Lys Lys His Phe Pro 
65                  70                  75                  80  


Phe Leu His Tyr Tyr Asp Asn Val Gln Ser Asp Glu Ile Ala Pro Tyr 
                85                  90                  95      


Leu Asn Ser Ile Lys Asp Leu Asn Ile Tyr Ser Asn Lys Pro Glu Glu 
            100                 105                 110         


Val Pro Lys Asp Asp Asp Pro Gly Met Cys Ile Trp Trp Leu Ser Tyr 
        115                 120                 125             


Val Phe Leu Pro Ile Leu Asn Arg Leu Arg Asn Glu Thr Ala His Tyr 
    130                 135                 140                 


Gly His Thr Lys Leu Gly Gly Asp Ile Pro Phe Leu Glu Gln Ser Phe 
145                 150                 155                 160 


Asn Glu Thr Ile Lys Glu Ala Gln Lys Arg Met Asn Tyr Ser His Glu 
                165                 170                 175     


Asp Val Glu His Leu Leu Arg Thr Asp Ser Tyr Tyr Lys Pro Leu Ser 
            180                 185                 190         


Ile Asn Lys Ser Leu Ser Glu Lys Gly Ile Phe Tyr Leu Tyr Cys Leu 
        195                 200                 205             


Phe Leu Asp Lys Lys Asn Gly Tyr Gln Phe Leu Ser His Ile Lys Gly 
    210                 215                 220                 


Phe Lys Asp Arg Arg Glu Thr Ala Lys Lys Ala Thr Thr Glu Val Phe 
225                 230                 235                 240 


Thr His Asn His Cys Arg Leu Pro Tyr Pro Lys Leu Asp Ser Ser Asp 
                245                 250                 255     


Leu Ala Leu Asp Ile Leu Asn Glu Leu Asn Arg Cys Pro Gly Ala Leu 
            260                 265                 270         


Tyr Ser Val Leu Ser Asp Asp Asp Arg Lys Lys Phe Val Thr Thr Leu 
        275                 280                 285             


Pro Thr Ala Glu Glu Gly Asp Glu Val Met Glu Ser Val Met Lys Arg 
    290                 295                 300                 


Gly Lys Glu Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Leu Glu Gln 
305                 310                 315                 320 


Glu Gly Val Leu Arg Gly Ile Ser Phe Gln Leu Phe Leu Gly Arg Phe 
                325                 330                 335     


Glu Gln Lys Glu Ala His His Lys Ile Val Gly Gln Glu Met Arg Glu 
            340                 345                 350         


His Lys Leu Leu Lys Asn Ile His Thr Phe Gly Gln Leu Glu Arg Phe 
        355                 360                 365             


Lys Thr Glu Ala Ala Asn Asn Phe Phe Leu Asn Glu Lys Lys Gly Ile 
    370                 375                 380                 


Val Glu Phe Tyr Ala Pro Ala Tyr Arg Met Val Gly Asn Arg Ile Gly 
385                 390                 395                 400 


Leu Ile Leu Lys Asp Ala Asn Ile Asn Asp Thr Gly Phe Glu Glu Val 
                405                 410                 415     


Leu Asp Asn Tyr Lys Leu Pro Leu Glu Glu Arg Asn Cys Pro Asp Ala 
            420                 425                 430         


Ile Met Ser Thr His Glu Leu Thr Ala Leu Phe Phe Tyr Asn Tyr Leu 
        435                 440                 445             


His Arg Glu Gly Ile Ile Arg Thr Ser Pro Lys Glu His Ile Leu Ser 
    450                 455                 460                 


Phe Leu Gln Asn Phe Lys Arg Phe Arg Glu Asp Leu Lys Lys Gly Lys 
465                 470                 475                 480 


Leu Lys Pro Ile Pro Gly Glu His Lys Leu Tyr Lys Met Lys Cys His 
                485                 490                 495     


Lys Gln Gly Ser Ser Asn Glu Leu Asn Arg Lys Arg Ile Leu Leu Gln 
            500                 505                 510         


Glu Ile Leu Asn Glu Tyr Gly Leu Lys Val Ala Trp Leu Pro Asp Ala 
        515                 520                 525             


Cys Arg Glu Tyr Leu Leu Gly Tyr Thr Ser Ser Asp Asn Thr His Ile 
    530                 535                 540                 


Ile Lys Gln Glu Phe Leu Lys Met Leu Asn Ser Ser Lys Ser Arg Arg 
545                 550                 555                 560 


Asp Lys Ile Ile Ala Phe Asn Lys Ser Ile Ser Glu Tyr Lys Lys Arg 
                565                 570                 575     


Asn Glu Ile Lys Leu Thr Gln Ala Lys Leu Glu Ile Arg Thr Gly Glu 
            580                 585                 590         


Leu Ala Thr Gln Leu Ala Arg Asp Ile Ile Tyr Met Thr Ser Pro Met 
        595                 600                 605             


Asn Lys Glu Gly Lys Ser Lys Lys Met Asn Asp Leu Glu Tyr Asn Val 
    610                 615                 620                 


Leu Gln Ser Met Leu Ala Tyr Phe Pro Leu His Lys Asn Glu Leu Thr 
625                 630                 635                 640 


Ala Tyr Leu Gly Ile Leu Lys Glu Gly Lys Val Trp Lys His Pro Phe 
                645                 650                 655     


Leu Glu Asp Val Leu Lys Glu Leu His Ser Ala Gln Ser Leu Ala Asp 
            660                 665                 670         


Phe Tyr Ser Leu Tyr Tyr Asp Ala Lys Ile Asp Trp Ile Asn His Lys 
        675                 680                 685             


Ile Ile Lys Glu Gln Val Glu His Asp Asn Asn Lys Lys Lys Tyr Ser 
    690                 695                 700                 


Trp Thr Leu Arg Val Gly Ala Glu Lys Met Val Thr Glu Gln Tyr Ala 
705                 710                 715                 720 


Tyr Leu Leu Asn Leu Glu Lys Lys Thr Lys Thr Ala Pro Gln Lys Glu 
                725                 730                 735     


Tyr Ala Asp Lys Ala Val Phe Leu Pro Thr Gly Leu Phe Asp Glu Ala 
            740                 745                 750         


Ile Ser Lys Ser Leu Ile Asp Lys Gly Tyr Glu Leu Arg Glu Asn Ser 
        755                 760                 765             


Asn Thr Ala Gly Cys Leu Lys Val Tyr Leu Asn Lys Glu Thr Gln Pro 
    770                 775                 780                 


Met Tyr Ser Glu Leu Lys Arg Tyr Tyr Arg Tyr Val Thr Gly Arg Gly 
785                 790                 795                 800 


Pro Arg Leu Thr Gly Arg Met Met Glu Arg Glu Glu Ala Lys Asn Phe 
                805                 810                 815     


Leu Ser His Asn Phe Ala Asn Ser Ser Leu Gln Pro Met Lys Lys Glu 
            820                 825                 830         


Ser Leu Lys Gln Phe Gly Lys Lys Ile Lys Glu Lys Glu Ala Glu Ile 
        835                 840                 845             


Leu Arg Gln Gln Asn Asn Asp Arg Ala Leu Phe Leu Met Leu Tyr Ala 
    850                 855                 860                 


Met Pro Asp Ala Asn Gly Val Ser Arg Ile Val Lys Glu Lys Thr Gly 
865                 870                 875                 880 


Leu Cys Lys Leu Gly Phe Asp Leu Asn Asp Asn Leu Leu Asn Thr Glu 
                885                 890                 895     


Tyr Thr Val Lys Gln Thr Leu Val Arg Met Val Asn Asn Val Arg Val 
            900                 905                 910         


Glu Arg Val Val Thr Ala Thr Leu Pro Val Lys Arg Tyr Gly Glu Met 
        915                 920                 925             


Arg Arg Phe Leu Lys Asp Arg Arg Ile Asp Gly Leu Leu Leu Tyr Tyr 
    930                 935                 940                 


Pro Glu Gly Lys Glu Ile Pro Leu Gly Thr Leu Glu Ser Ser Lys Thr 
945                 950                 955                 960 


Ala Leu Lys Gly Glu Lys Tyr Ser Tyr Ser Asn Leu Ile Asp Glu Leu 
                965                 970                 975     


Asp Val Tyr Asp Arg Lys Arg Asn Glu Leu Met Glu Arg Ile Tyr Glu 
            980                 985                 990         


Val Asp Arg Leu Met Ala Val Asn  Phe Pro Leu Ile Lys  Lys Lys Thr 
        995                 1000                 1005             


Lys Gly  Asn Ala Ser Tyr Tyr  Glu His Tyr Asp Cys  Leu Asp Tyr 
    1010                 1015                 1020             


Ala Arg  Thr Asn Leu Gly Leu  Ala Asn Gln Val Ser  Leu Leu Gln 
    1025                 1030                 1035             


Arg Glu  Arg Ile Thr Leu Leu  Arg Ser Lys Leu Ala  His Asn Gln 
    1040                 1045                 1050             


Ile Pro  Tyr Glu Ala Trp Ile  Cys Glu Glu Ile Glu  Lys Met Asp 
    1055                 1060                 1065             


Asp Pro  Leu Ile Thr Ser Arg  Ile Ile Asn Leu Val  Ala Ser Cys 
    1070                 1075                 1080             


Tyr Glu  Glu Leu Leu Leu Ser  Ile Lys Lys Lys Ile  Thr Glu 
    1085                 1090                 1095         


<210>  2619
<211>  1129
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2619

Met Glu Thr Asn Gln Gln Thr His Glu Asn Arg Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Asn Asn His Val Ala Thr Asp Phe Lys Gln Ala Thr 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ala Ser Phe Leu Cys Asn Lys Thr 
    50                  55                  60                  


Ile Lys Asn Leu Asn Trp Asn His Val His Thr Arg Ala Leu Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ser Glu Ser Leu Pro Lys Asp Glu 
                85                  90                  95      


Arg Glu Asn Ser Asp Thr Glu Gly Lys Asp Phe Thr Ser Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Phe Val Phe Ser Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gln Asp Ser Arg Lys Leu Thr Val 
    130                 135                 140                 


Ser Pro Glu Leu Ala Asn Phe Leu Thr Val Asn Phe Gln Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Ala Arg Met Lys Asp Val Leu Thr Asp Ala Asp Tyr 
                165                 170                 175     


Ala Leu Val Glu Asn Leu Gln Met Ala Ala Thr Asp Asn Arg Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ala Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asn Leu Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Ser 
            260                 265                 270         


Val Ile Thr Asp Lys Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Asp Asp Glu Arg 
    290                 295                 300                 


Glu Thr Ile Leu Asp Glu Ile Asp Tyr Gln Asp Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg Tyr Ser Asn Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Asp Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Asn Tyr Thr Lys Gln Phe Ala Gly Glu 
        355                 360                 365             


Gln Ala Glu Arg Lys Val Leu Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asp Pro Glu Leu Ile Gln Gln Arg Ile Asp Lys Gln 
385                 390                 395                 400 


Gln His Thr Ala Gly Phe Asp Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Asn Ile Ala Thr Leu Ile 
            420                 425                 430         


Ala Lys Ser Lys Ala Gly Ser Lys Val Glu His Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Gln Ala Glu Glu Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Ile Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Ser Gln Leu Pro Ala Asn Trp Asp Glu Phe Ser Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asp Ser Thr Leu Lys Tyr Leu 
        515                 520                 525             


Arg Gln Arg Lys Thr Thr Leu Asn Thr Ile Leu Ser Lys Ser Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Ile Pro Thr Lys Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Lys Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Thr Arg Leu Lys Ala Val Glu Lys His Lys Leu 
            580                 585                 590         


Asn Lys Ser Val Lys Ile Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Lys Glu Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Ala Asn Ala Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Phe Glu Asn Gly Gly His Pro Phe Leu Gln Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Gln Ala Tyr Leu Val 
        675                 680                 685             


Glu Lys Gly Asn Lys Met Val Pro Arg Leu Asn Pro Lys Thr Asn Lys 
    690                 695                 700                 


Thr Ser Lys Val Asp Glu Ser Trp Met Met Lys Gln Phe Tyr Val Lys 
705                 710                 715                 720 


Glu Trp Lys Glu Glu Ile Ala Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Ser Gln Ile Pro Phe Thr Ile Arg Gln Trp Asp Glu Lys 
            740                 745                 750         


Glu Lys Tyr Asp Leu Asn Ala Trp Leu Gln His Val Thr Val Gly Lys 
        755                 760                 765             


Asn Lys Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe Asp 
    770                 775                 780                 


Glu Ala Leu Cys Asp Leu Leu Arg Glu Gln Leu Asp Thr Lys Ile Val 
785                 790                 795                 800 


Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Ile Trp Trp 
                805                 810                 815     


Lys Thr Arg Asn Asp Asp Thr Gln Gln Phe Tyr Gln Ser Glu Arg Glu 
            820                 825                 830         


Tyr Asp Ile Tyr Asn Glu Lys Val Arg Phe Lys Ile Asp Ser Ser Thr 
        835                 840                 845             


His Phe Ala Asp Tyr Tyr Lys Asn Ala Leu Ser Arg Ala Phe Thr Arg 
    850                 855                 860                 


Leu Lys Ala Glu Arg Glu Thr Ala Arg Gln Thr Asn Lys Arg Leu Pro 
865                 870                 875                 880 


Pro Leu Glu Tyr Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile Ala 
                885                 890                 895     


Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met Ala 
            900                 905                 910         


Val Leu Met Leu Glu Arg Leu Met Asp Asn Ser Pro Asn Leu Arg Leu 
        915                 920                 925             


Ser Lys Ile Glu Thr Leu Leu Asn Asp Thr Thr Pro Ile Ser Glu Lys 
    930                 935                 940                 


Ile Ser Ala Thr Leu Ser Phe Asp Ala Ser Gly Glu Arg Ile Thr Asp 
945                 950                 955                 960 


Lys Ser Asn Pro Thr Val Thr Lys Thr Leu Val Ala Glu Arg Lys Gln 
                965                 970                 975     


Lys Asn Tyr Thr Glu Leu Gln Lys Tyr Arg Tyr Asp Arg Arg Leu Pro 
            980                 985                 990         


Glu Leu Phe Glu Tyr Val Gln Ala  Asp Glu Ile Pro Leu  Glu Trp Leu 
        995                 1000                 1005             


Leu Asp  Glu Leu Ser Ala Tyr  Asn Asn Ala Lys Gln  Gln Val Phe 
    1010                 1015                 1020             


Asp Thr  Val Phe Ala Leu Glu  Lys Lys Ile Ile Gln  Thr Asp Pro 
    1025                 1030                 1035             


Asp Glu  Leu Lys Ser Leu Phe  Thr Gly Ala Asn Gly  Glu Leu Gln 
    1040                 1045                 1050             


Thr Gly  Asn Ile Gln His Lys  Pro Tyr Val Gln Trp  Leu Thr Asn 
    1055                 1060                 1065             


Lys Gly  Leu Ile Asn Lys Glu  Glu Lys Gln Phe Ile  Asn Met Val 
    1070                 1075                 1080             


Arg Lys  Cys Phe Ser His Asn  Gln Phe Pro Gln Arg  Lys Thr Met 
    1085                 1090                 1095             


Glu Leu  Leu Ile Pro Ala Trp  Asn Glu Lys Lys Leu  Gly Leu Gln 
    1100                 1105                 1110             


Ile Ala  Thr Val Tyr Asn Gln  Leu Ile Ala Asp Leu  Thr Asp Lys 
    1115                 1120                 1125             


Ile 
    


<210>  2620
<211>  1119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2620

Met Glu Thr Gln Thr Lys Thr Glu His Gln Ala Ala Lys Ile Tyr Lys 
1               5                   10                  15      


Thr Ile Glu Ser Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala 
            20                  25                  30          


Arg His Asn Ile Tyr Ser Ile Ser Asn His Ala Ser Ser Lys Phe Asn 
        35                  40                  45              


Ile Lys Pro Leu Ser Asp Glu Glu Lys Ile Ile Asp Ser Phe Leu Cys 
    50                  55                  60                  


Asn Glu Lys Arg Lys His Leu Asn Trp Asn His Val Phe Ser Ile Ala 
65                  70                  75                  80  


Leu Lys Phe Leu Pro Ile Ile Lys Val Phe Asp Phe Glu Gly Leu Pro 
                85                  90                  95      


Lys Asn Glu Lys Ala Asp Asn Asn Asn Thr Gly Lys Asp Phe Ala Gln 
            100                 105                 110         


Met Ala Gln Thr Leu Lys Lys Leu Phe Ser Glu Ile Gln Gln Leu Arg 
        115                 120                 125             


Asn Asp Tyr Ser His Tyr Tyr Ser Ile Asn Asn Lys Asp Ile Arg Lys 
    130                 135                 140                 


Ile Ser Val Ser Asn Glu Val Ala Ile Phe Leu Gln Asp Asn Ile Lys 
145                 150                 155                 160 


Arg Ala Ile Glu Tyr Thr Lys Ser Arg Phe Ser Gly Val Leu Ser Asp 
                165                 170                 175     


Glu Asp Phe Glu Asn Ala Ser Asn Arg Lys Leu Ile Glu Gln Asn Asn 
            180                 185                 190         


Ile Leu Thr Thr Asp Gly Phe Val Phe Leu Ile Ser Met Phe Leu Glu 
        195                 200                 205             


Arg Glu His Ala Phe Gln Phe Ile Gly Lys Ile Lys Gly Leu Lys Gly 
    210                 215                 220                 


Thr Gln Ser Lys Ser Phe Ile Ala Thr Arg Glu Val Phe Met Ala Phe 
225                 230                 235                 240 


Cys Leu Lys Leu Pro His Asp Arg Phe Val Ser Glu Asp Lys Thr Gln 
                245                 250                 255     


Ala Leu Thr Leu Asp Ile Ile Asn Thr Leu Asn Arg Cys Pro Lys Glu 
            260                 265                 270         


Leu Tyr Ser Ile Ile Thr Glu Lys Glu Lys Gln Gln Phe Lys Pro Thr 
        275                 280                 285             


Leu Asp Asn Leu Lys Leu Asn Asn Leu Leu Glu Asn Ser Leu Asn Asn 
    290                 295                 300                 


Thr Glu Val Ile Glu Asp Tyr Asp Thr Tyr Ile Glu Ser Leu Thr Arg 
305                 310                 315                 320 


Lys Ile Arg His Ser Asn Arg Phe Ser Tyr Phe Ala Leu Lys Tyr Ile 
                325                 330                 335     


Asp Glu Thr Asn Ile Phe Gln Asn Ile Arg Phe Gln Ile Asn Leu Gly 
            340                 345                 350         


Lys Leu Leu Ile Asp Lys Tyr Glu Lys Pro Ile Asn Asn Glu Met Tyr 
        355                 360                 365             


Pro Arg Thr Ile Ile Glu Asn Val Lys Ala Phe Gly Lys Leu Ser Asp 
    370                 375                 380                 


Phe Glu Asp Glu Thr Glu Ala Leu His Gln Ile Asp Lys Asn Gly Asn 
385                 390                 395                 400 


Ser Leu Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Thr Ser Asn Asn 
                405                 410                 415     


Lys Ile Ala Leu Tyr Thr Asn Asn Ala Lys Ala Ile Ile Ile Asn Asn 
            420                 425                 430         


Pro Lys Ala Lys Ser Lys Ile Lys Asn Asn Leu Lys Gln Pro Leu Pro 
        435                 440                 445             


Glu Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu Leu Glu 
    450                 455                 460                 


Tyr Leu Gln Lys Gly Lys Ser Glu Glu Ile Ile Asn Asp Phe Ile Leu 
465                 470                 475                 480 


Ala Asn Asn Thr Lys Ile Thr Asn Arg Lys Phe Ile Glu Glu Val Lys 
                485                 490                 495     


Arg Met Leu Pro Asn Asp Trp Asp Ile Phe Lys Lys Lys Thr Asp Pro 
            500                 505                 510         


Lys Asn Ser Gln Ala Tyr Lys Pro Ser Glu Leu Thr Lys Leu Lys Thr 
        515                 520                 525             


Arg Lys Lys Ile Leu Asn Thr Val Leu Glu Pro His Asn Leu Asn Asp 
    530                 535                 540                 


Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp Leu Asn Ile Val Asp 
545                 550                 555                 560 


Val Asn Ile Asp Arg Ala Ile Ala Asp Lys Ile Lys Leu Met Lys Arg 
                565                 570                 575     


Asp Gly Thr Asp Arg Leu Lys Ala Phe Asn Lys Phe Lys Lys Glu Gly 
            580                 585                 590         


Lys Gly Lys Ile Pro Lys Ile Gly Glu Met Ala Thr Phe Leu Ala Lys 
        595                 600                 605             


Asp Ile Val Asn Met Ile Ile Ser Glu Asp Lys Lys Lys Lys Ile Thr 
    610                 615                 620                 


Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp 
625                 630                 635                 640 


Pro Glu Lys Lys Ala Leu Phe Ile Glu Ile Ile Thr Lys Asp Leu Gln 
                645                 650                 655     


Leu Asn Lys Phe Asp Gly His Pro Phe Leu Lys Glu Ile Gln Leu Arg 
            660                 665                 670         


Asp Ile His Tyr Thr Gln Asp Phe Tyr Ser Ile Tyr Leu Gln His Lys 
        675                 680                 685             


Val Cys Lys Leu Val Ser Val Lys Asn Tyr Lys Lys Gly Arg Thr Asp 
    690                 695                 700                 


Ser Ile Asp Lys Ser Trp Met Thr Lys Asn Phe Tyr Cys Lys Glu Trp 
705                 710                 715                 720 


Asp Asn Lys Leu Ser Lys Gln Lys Thr Val Val Lys Leu Pro Ala Asp 
                725                 730                 735     


Leu Ser Asn Ile Pro Phe Ser Leu Arg Gln Leu Ile Glu Lys Lys Ser 
            740                 745                 750         


Ser Ser Leu Tyr Asp Trp Leu Asp Asn Ile Val Asn Gly Lys Asn Ser 
        755                 760                 765             


Asn Asp Ser Lys Arg Pro Ile Ser Leu Pro Thr Asn Leu Phe Asp Asp 
    770                 775                 780                 


Glu Leu Ile Asn Leu Leu Gln Met Lys Leu Asn Glu Lys Asn Val Ser 
785                 790                 795                 800 


Tyr Pro His Asp Ala Lys Tyr Asn Glu Leu Phe Lys Ile Trp Trp Thr 
                805                 810                 815     


Thr Arg Asn Asp Asp Thr Gln Ser Phe Tyr Lys Ala Glu Arg Glu Tyr 
            820                 825                 830         


Val Ile Tyr Asp Gln Lys Ile Asn Phe Lys Leu Gln Lys Gly Ala Lys 
        835                 840                 845             


Phe Ala Asp Phe Tyr Thr Asp Ser Leu Lys Gln Ala Phe Lys Asn Gln 
    850                 855                 860                 


Gln Asp Lys Arg Ala Ile Glu Lys Arg Val Asp Arg Lys Leu Pro Asn 
865                 870                 875                 880 


Ile Glu Leu Thr Gln Val Glu Lys Val Phe Lys Arg Thr Ile Ser Asn 
                885                 890                 895     


Thr Glu Lys Gln Ile Arg Leu Thr Gln Glu Gln Asp Gln Ile Met Ala 
            900                 905                 910         


Leu Met Leu Glu Lys Leu Met Ser Asp Asp Lys Asn Leu Asn Ile Lys 
        915                 920                 925             


Leu Ser Glu Ile Ser Thr Leu Leu Asn Asp Thr Ile Thr Val Arg Lys 
    930                 935                 940                 


Thr Val Ser Gly Lys Leu Ser Phe Ser Asn Glu Asn Pro Ile Ser Lys 
945                 950                 955                 960 


Ile Ile Leu Asp Gln Arg Lys Arg Lys Asp His Ser Met Leu Asn Lys 
                965                 970                 975     


Tyr Ser Asn Asp Lys Arg Leu Pro Glu Leu Leu Glu Tyr Phe Val Asp 
            980                 985                 990         


Asn Glu Ile Pro Ile Asp Lys Leu  Lys Leu Glu Leu Glu  Ala Tyr Asn 
        995                 1000                 1005             


Asn Ala  Lys His Ile Val Leu  Asp Ser Ala Phe Lys  Leu Glu Ala 
    1010                 1015                 1020             


Thr Leu  Ile Ser Lys Asn Tyr  Lys Asn Gln Ile Leu  Ser Phe Ile 
    1025                 1030                 1035             


Asp Asn  Asn Phe Lys Gly Gln  Ser Ile Gln His Lys  Pro Tyr Leu 
    1040                 1045                 1050             


Met Phe  Leu Gln Ser Lys Gly  Val Ile Asn Glu Asn  Glu Phe Arg 
    1055                 1060                 1065             


Phe Leu  Asn Met Val Arg Asn  Cys Phe Ser His Asn  Gln Phe Pro 
    1070                 1075                 1080             


Gln Lys  Ser Thr Met Asn Leu  Leu Ile Asn Asp Trp  Asp Lys Asn 
    1085                 1090                 1095             


Asn Phe  Ala Leu Gln Ile Ala  Thr Ile Tyr Asn Asn  Lys Thr Glu 
    1100                 1105                 1110             


Thr Ile  Met Thr Lys Leu 
    1115                 


<210>  2621
<211>  1165
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2621

Met Thr Thr Asp Gln Phe Ser Gly Lys Gly Ile Lys Tyr Thr Leu Glu 
1               5                   10                  15      


Asp Lys Phe Phe Trp Ala Ala Val Phe Asn Leu Ala Arg His Asn Ala 
            20                  25                  30          


Phe Ile Thr Ile Asn His Ile Asn Gln Gln Leu Gly Ile Lys Pro Ile 
        35                  40                  45              


Glu Asn Asp Gln Asp Ile Asn Ser Ile Lys Ile Ser Trp Asn Ala Ser 
    50                  55                  60                  


Phe Asp Ser Glu Asn Leu Glu Arg Lys Ala Lys Leu Tyr Ala Leu Ile 
65                  70                  75                  80  


Asn Lys His Phe Pro Phe Leu Ile Ala Ser Ser Tyr Gly Gln Arg Ser 
                85                  90                  95      


Tyr Glu Val Met Ser Ser Ile Pro Ile Gly Lys Asn Gly Arg Thr Arg 
            100                 105                 110         


Leu Lys Ser Asn Val Glu Arg Lys Thr Glu Gln Ala Asp Ser Leu Asp 
        115                 120                 125             


Leu Lys Met Leu Leu Asp Leu Leu Ile Val Phe Ile Glu Lys Leu Arg 
    130                 135                 140                 


Asp Phe Arg Asn Tyr Tyr Ser His Tyr Lys His Ser Lys Gln Asn Ser 
145                 150                 155                 160 


Leu Pro Lys Leu Asp Val Gly Leu Met Asn Arg Leu Tyr Asp Ile Phe 
                165                 170                 175     


Asp Ser Asn Val Arg Met Val Lys Gln Asp His Lys His Asn Thr Lys 
            180                 185                 190         


Ile Asp Pro Arg Lys Asp Phe Asp His Leu Ile Arg Lys Ser Lys Ser 
        195                 200                 205             


Gly Val Asn Pro Lys Phe Lys Ser His Phe Ala Asn Gly Glu Glu Ile 
    210                 215                 220                 


Thr Glu Ala Gly Leu Leu Phe Phe Ala Ser Ile Phe Leu Glu Lys Lys 
225                 230                 235                 240 


Asp Ala Ile Trp Ile Gln Arg Lys Ile Phe Gly Phe Lys Gly Ser Asn 
                245                 250                 255     


Gln Thr Phe Met Gln Met Thr Asn Glu Val Phe Cys Arg Thr Arg Ile 
            260                 265                 270         


Leu Leu Pro Lys Leu Arg Leu Glu Ser Asn Tyr Asp Asn Asp Gln Leu 
        275                 280                 285             


Leu Leu Glu Met Leu Gly Glu Leu Ala Lys Cys Pro Lys Thr Phe Phe 
    290                 295                 300                 


Asp Arg Leu Ser Glu Asn Asp Arg Gln Lys Phe Met Ile Pro Ile Glu 
305                 310                 315                 320 


Ile Tyr Asp Phe Glu Asn Asp Glu Ser Ile Asp Asn Asp Pro Phe Lys 
                325                 330                 335     


Asn Ile Leu Val Arg His His Asn Arg Phe Ser Tyr Phe Ala Leu Arg 
            340                 345                 350         


Tyr Phe Asp Leu Asn Asn Val Phe Lys Asp Leu Arg Phe Gln Ile Asp 
        355                 360                 365             


Leu Gly Asn Tyr His Phe Ser Ile Tyr Asp Lys Lys Ile Gly Asp Gln 
    370                 375                 380                 


Ile Glu Lys Arg His Leu Thr Arg Asn Leu Phe Ser Phe Gly Arg Ile 
385                 390                 395                 400 


Gln Ser Phe Asp Glu Val Asn Leu Pro Leu Glu Trp Lys Asn Leu Val 
                405                 410                 415     


Arg Asp Leu Asp Tyr Tyr Glu Ser Ser Asp Leu Pro Phe Ile Ser Lys 
            420                 425                 430         


Thr Thr Pro His Tyr His Leu Val Ser Asn Lys Ile Gly Leu Lys Phe 
        435                 440                 445             


Ala Asn Tyr Asp Ser Lys Trp Pro Gly Leu Glu Ile Thr Asp Ala His 
    450                 455                 460                 


Glu Arg Lys Ala Lys Tyr Val Tyr Asp Asn Gln Phe Val Ala Asp Gly 
465                 470                 475                 480 


Phe Leu Ser Val Tyr Glu Leu Val Pro Met Met Phe Tyr Tyr Leu Leu 
                485                 490                 495     


Thr Glu Asp Gly Gln Lys Val Glu Gly Val Leu Lys Ser Thr Lys Glu 
            500                 505                 510         


Lys Ala Tyr Lys Ile Phe Glu Glu Phe Gln Glu Tyr Arg Leu Asn Ser 
        515                 520                 525             


Ile Gln Asp Leu Lys Asn Leu Thr Ser Gln Thr Asn Ile His Pro Gly 
    530                 535                 540                 


Gln Leu Pro Lys Arg Leu Ile Asn Ile Leu Asn Asp Thr Glu Lys Asn 
545                 550                 555                 560 


Leu Glu Asn Glu Ala Arg Arg Lys Ile Ser Ile Leu Ile Glu Asn Thr 
                565                 570                 575     


Glu Lys Arg Ile Lys Gln Leu His Glu Gln Thr Asn Gln Lys Ile Arg 
            580                 585                 590         


Ile Gly Lys Pro Asn Asn Gly Leu Leu Lys Pro Gly Lys Ile Ala Asp 
        595                 600                 605             


Trp Leu Ile Lys Asp Leu Met Arg Phe Gln Pro Val Ala Phe Asp Gln 
    610                 615                 620                 


Phe Asn Gln Pro Leu Asn Arg Ser Lys Ala Asn Ser Thr Glu Tyr Gln 
625                 630                 635                 640 


Leu Leu Gln Lys Thr Phe Ala Leu Tyr Gly Ser Glu Lys Asp Arg Leu 
                645                 650                 655     


Pro Ala Tyr Leu Arg Gln Leu Asn Leu Val Gly Ser Asn Asn Pro His 
            660                 665                 670         


Ala Phe Leu Ser Glu Phe Asn Trp Ala Asn Gln Ser Asn Leu Leu Ser 
        675                 680                 685             


Phe Tyr Glu Ala Tyr Leu Thr Ala Arg Leu Ile Phe Leu Gln Lys Leu 
    690                 695                 700                 


Asn Val Glu Lys Trp Met Glu Tyr Gln Tyr Phe Leu Leu Leu Arg Thr 
705                 710                 715                 720 


Lys Lys Thr Asp Arg Asn Lys Leu Val Ala Gly Trp Lys Asn Gly Phe 
                725                 730                 735     


Asn Phe Pro Arg Gly Leu Phe Thr Gln Pro Ile Lys Glu Trp Phe Ala 
            740                 745                 750         


Lys Phe Asp Ser Gly Ile Ser Lys Glu Ile Glu Asn Tyr Glu Ser Thr 
        755                 760                 765             


Gly Leu Ile Ala Arg Val Ile Pro Leu Phe Phe Glu Lys Lys Tyr Asn 
    770                 775                 780                 


Asp Ser Ala Gln Ala Phe Tyr Ser Phe Asp Phe Asn Ile Gly Asn Pro 
785                 790                 795                 800 


Glu Lys Pro Lys Asp Gly Val Phe Leu Ser Lys Ser Gln Arg Glu Asp 
                805                 810                 815     


Leu Trp Lys Ile Thr Lys Ser Lys Leu Arg Leu Asp Lys Asp Ser Pro 
            820                 825                 830         


Asp Leu Glu Asn Thr Ile Ala Lys Ile Glu Lys Ala Phe Glu Asp Ile 
        835                 840                 845             


Asn Tyr Ser Asn Ile Asp Trp Asn Ile Arg Arg Glu Arg Leu His Lys 
    850                 855                 860                 


Leu Ile His Glu Leu Asn Ile Gln Asp Lys Val Leu Pro Glu Leu Glu 
865                 870                 875                 880 


Lys Arg Asn Ser Asn Leu Lys Leu Lys Thr Lys Ile Ser Glu Ala Ala 
                885                 890                 895     


Ser Glu Lys Phe Arg Glu Thr Phe Asn Phe Arg Lys Trp Gln Gly Phe 
            900                 905                 910         


Glu Lys Glu Leu Arg Leu Tyr Lys Asn Gln Asp Met Leu Ile Trp Leu 
        915                 920                 925             


Leu Cys Arg Asn Leu Arg Thr Asp Ser Gln Leu Ile Asn Leu Asn Ile 
    930                 935                 940                 


Asn Asn Leu Tyr Leu Lys Asn Ile Asp Thr Asp Val His Ser Thr Gln 
945                 950                 955                 960 


Ser Leu Asn Ile Leu Asn Arg Val Leu Pro Met Lys Leu Ser Ile Pro 
                965                 970                 975     


Ile Tyr Pro Thr Asp Glu Lys Gly Asn Val Phe Lys Lys Met Thr Pro 
            980                 985                 990         


Thr Val Val Val Gln Ile Glu Glu  Lys Glu Thr Lys Val  Leu Lys His 
        995                 1000                 1005             


Gly Asn  Phe Lys Ala Leu Val  Lys Asp Arg Arg Leu  Asn Asn Leu 
    1010                 1015                 1020             


Phe Thr  Phe Ile Asp Ala Gly  Pro Ala Asp Phe Gly  Asn Phe Ser 
    1025                 1030                 1035             


Ile Ser  Lys Lys Arg Ile Glu  Ala Glu Leu Ala Lys  Tyr Gln Val 
    1040                 1045                 1050             


Ser Arg  Ile Glu Val Phe Lys  Ile Thr Leu Glu Ile  Glu Lys Asn 
    1055                 1060                 1065             


Ile Val  Asp Ala Tyr Pro Asn  Leu Pro Thr Asp Asn  Phe Arg Glu 
    1070                 1075                 1080             


Leu Leu  Gly Glu Trp Leu Asn  Ile Lys Val Asn Gln  Ser Glu Leu 
    1085                 1090                 1095             


Arg Cys  Phe Thr Gln Ile Leu  Val Ser Ile Arg Asn  Ala Phe Ala 
    1100                 1105                 1110             


His Asn  Gln Tyr Pro Arg Tyr  Cys Asp Glu Lys Phe  Gly Ser Ile 
    1115                 1120                 1125             


Asn Arg  Phe Asn Ile Ser Asn  Pro Asn Thr Ala Glu  Ser Asn Gly 
    1130                 1135                 1140             


Leu Asn  Ile Ala Ile Gln Leu  Leu Asp Leu Ala Thr  Thr Ile Lys 
    1145                 1150                 1155             


Ser Leu  Ile Ile Lys Glu Leu  
    1160                 1165 


<210>  2622
<211>  1165
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2622

Met Thr Thr Asp Gln Phe Ser Gly Lys Gly Ile Lys Tyr Thr Leu Glu 
1               5                   10                  15      


Asp Lys Phe Phe Trp Ala Ala Val Phe Asn Leu Ala Arg His Asn Ala 
            20                  25                  30          


Phe Ile Thr Ile Asn His Ile Asn Gln Gln Leu Gly Ile Lys Pro Ile 
        35                  40                  45              


Glu Asn Asp Gln Asp Ile Asn Ser Ile Lys Ile Ser Trp Asn Ala Ser 
    50                  55                  60                  


Phe Asp Ser Glu Asn Leu Glu Arg Lys Ala Lys Leu Tyr Ala Leu Ile 
65                  70                  75                  80  


Asn Lys His Phe Pro Phe Leu Ile Ala Ser Ser Tyr Gly Gln Arg Ser 
                85                  90                  95      


Tyr Glu Val Met Ser Ser Ile Pro Ile Gly Lys Asn Gly Arg Thr Arg 
            100                 105                 110         


Leu Lys Ser Asn Val Glu Arg Lys Thr Glu Gln Ala Asp Ser Leu Asp 
        115                 120                 125             


Leu Lys Met Leu Leu Asp Leu Leu Ile Val Phe Ile Glu Lys Leu Arg 
    130                 135                 140                 


Asp Phe Arg Asn Tyr Tyr Ser His Tyr Lys His Ser Lys Gln Asn Ser 
145                 150                 155                 160 


Leu Pro Lys Leu Asp Val Gly Leu Met Asn Arg Leu Tyr Asp Ile Phe 
                165                 170                 175     


Asp Ser Asn Val Arg Met Val Lys Gln Asp His Lys His Asn Thr Lys 
            180                 185                 190         


Ile Asp Pro Arg Lys Asp Phe Asp His Leu Ile Arg Lys Ser Lys Ser 
        195                 200                 205             


Gly Val Asn Pro Lys Phe Lys Ser His Phe Ala Asn Gly Glu Glu Ile 
    210                 215                 220                 


Thr Glu Ala Gly Leu Leu Phe Phe Ala Ser Ile Phe Leu Glu Lys Lys 
225                 230                 235                 240 


Asp Ala Ile Trp Ile Gln Arg Lys Ile Phe Gly Phe Lys Gly Ser Asn 
                245                 250                 255     


Gln Thr Phe Met Gln Met Thr Asn Glu Val Phe Cys Arg Thr Arg Ile 
            260                 265                 270         


Leu Leu Pro Lys Leu Arg Leu Glu Ser Asn Tyr Asp Asn Asp Gln Leu 
        275                 280                 285             


Leu Leu Glu Met Leu Gly Glu Leu Ala Lys Cys Pro Lys Thr Phe Phe 
    290                 295                 300                 


Asp Arg Leu Ser Glu Asn Asp Arg Gln Lys Phe Met Ile Pro Ile Glu 
305                 310                 315                 320 


Ile Tyr Asp Phe Glu Asn Asp Glu Ser Ile Asp Asn Asp Pro Phe Lys 
                325                 330                 335     


Asn Ile Leu Val Arg His His Asn Arg Phe Ser Tyr Phe Ala Leu Arg 
            340                 345                 350         


Tyr Phe Asp Leu Asn Asn Val Phe Lys Asp Leu Arg Phe Gln Ile Asp 
        355                 360                 365             


Leu Gly Asn Tyr His Phe Ser Ile Tyr Asp Lys Lys Ile Gly Asp Gln 
    370                 375                 380                 


Ile Glu Lys Arg His Leu Thr Arg Asn Leu Phe Ser Phe Gly Arg Ile 
385                 390                 395                 400 


Gln Ser Phe Asp Glu Val Asn Leu Pro Leu Glu Trp Lys Asn Leu Val 
                405                 410                 415     


Arg Asp Leu Asp Tyr Tyr Glu Ser Ser Asp Leu Pro Phe Ile Ser Lys 
            420                 425                 430         


Thr Thr Pro His Tyr His Leu Val Ser Asn Lys Ile Gly Leu Lys Phe 
        435                 440                 445             


Ala Asn Tyr Asp Ser Lys Trp Pro Gly Leu Glu Ile Thr Asp Ala His 
    450                 455                 460                 


Glu Arg Lys Ala Lys Tyr Val Tyr Asp Asn Gln Phe Val Ala Asp Gly 
465                 470                 475                 480 


Phe Leu Ser Val Tyr Glu Leu Val Pro Met Met Phe Tyr Tyr Leu Leu 
                485                 490                 495     


Thr Glu Asp Gly Gln Lys Val Glu Gly Val Leu Lys Ser Thr Lys Glu 
            500                 505                 510         


Lys Ala Tyr Lys Ile Phe Glu Glu Phe Gln Glu Tyr Arg Leu Asn Ser 
        515                 520                 525             


Ile Gln Asp Leu Lys Asn Leu Thr Ser Gln Thr Asn Ile His Pro Gly 
    530                 535                 540                 


Gln Leu Pro Lys Arg Leu Ile Asn Ile Leu Asn Asp Thr Glu Lys Asn 
545                 550                 555                 560 


Leu Glu Asn Glu Ala Arg Arg Lys Ile Ser Ile Leu Ile Glu Asn Thr 
                565                 570                 575     


Glu Lys Arg Ile Lys Gln Leu His Glu Gln Thr Asn Gln Lys Ile Arg 
            580                 585                 590         


Ile Gly Lys Pro Asn Asn Gly Leu Leu Lys Pro Gly Lys Ile Ala Asp 
        595                 600                 605             


Trp Leu Ile Lys Asp Leu Met Arg Phe Gln Pro Val Ala Phe Asp Gln 
    610                 615                 620                 


Phe Asn Gln Pro Leu Asn Arg Ser Lys Ala Asn Ser Thr Glu Tyr Gln 
625                 630                 635                 640 


Leu Leu Gln Lys Thr Phe Ala Leu Tyr Gly Ser Glu Lys Asp Arg Leu 
                645                 650                 655     


Pro Ala Tyr Leu Arg Gln Leu Asn Leu Val Gly Ser Asn Asn Pro His 
            660                 665                 670         


Ala Phe Leu Ser Glu Phe Asn Trp Ala Asn Gln Ser Asn Leu Leu Ser 
        675                 680                 685             


Phe Tyr Glu Ala Tyr Leu Thr Ala Arg Leu Ile Phe Leu Gln Lys Leu 
    690                 695                 700                 


Asn Val Glu Lys Trp Met Glu Tyr Gln Tyr Phe Leu Leu Leu Arg Thr 
705                 710                 715                 720 


Lys Lys Thr Asp Arg Asn Lys Leu Val Ala Gly Trp Lys Asn Gly Phe 
                725                 730                 735     


Asn Phe Pro Arg Gly Leu Phe Thr Gln Pro Ile Lys Glu Trp Phe Ala 
            740                 745                 750         


Lys Phe Asp Ser Gly Ile Ser Lys Glu Ile Glu Asn Tyr Glu Ser Thr 
        755                 760                 765             


Gly Leu Ile Ala Arg Val Ile Pro Leu Phe Phe Glu Lys Lys Tyr Asn 
    770                 775                 780                 


Asp Ser Ala Gln Ala Phe Tyr Ser Phe Asp Phe Asn Ile Gly Asn Pro 
785                 790                 795                 800 


Glu Lys Pro Lys Asp Gly Val Phe Leu Ser Lys Ser Gln Arg Glu Asp 
                805                 810                 815     


Leu Trp Lys Ile Thr Lys Ser Lys Leu Arg Leu Asp Lys Asp Ser Pro 
            820                 825                 830         


Asp Leu Glu Asn Thr Ile Ala Lys Ile Glu Lys Ala Phe Glu Asp Ile 
        835                 840                 845             


Asn Tyr Ser Asn Ile Asp Trp Asn Ile Arg Arg Glu Arg Leu His Lys 
    850                 855                 860                 


Leu Ile His Glu Leu Asn Ile Gln Asp Lys Val Leu Pro Glu Leu Glu 
865                 870                 875                 880 


Lys Arg Asn Ser Asn Leu Lys Leu Lys Thr Lys Ile Ser Glu Ala Ala 
                885                 890                 895     


Ser Glu Lys Phe Arg Glu Thr Phe Asn Phe Arg Lys Trp Gln Gly Phe 
            900                 905                 910         


Glu Lys Glu Leu Arg Leu Tyr Lys Asn Gln Asp Met Leu Ile Trp Leu 
        915                 920                 925             


Leu Cys Arg Asn Leu Arg Thr Asp Ser Gln Leu Ile Asn Leu Asn Ile 
    930                 935                 940                 


Asn Asn Leu Tyr Leu Lys Asn Ile Asp Thr Asp Val His Ser Thr Gln 
945                 950                 955                 960 


Ser Leu Asn Ile Leu Asn Arg Val Leu Pro Met Lys Leu Ser Ile Pro 
                965                 970                 975     


Ile Tyr Pro Thr Asp Glu Lys Gly Asn Val Phe Lys Lys Met Thr Pro 
            980                 985                 990         


Thr Val Val Val Gln Ile Glu Glu  Lys Glu Thr Lys Val  Leu Lys His 
        995                 1000                 1005             


Gly Asn  Phe Lys Ala Leu Val  Lys Asp Arg Arg Leu  Asn Asn Leu 
    1010                 1015                 1020             


Phe Thr  Phe Ile Asp Ala Gly  Pro Ala Asp Phe Gly  Asn Phe Ser 
    1025                 1030                 1035             


Ile Ser  Lys Lys Arg Ile Glu  Ala Glu Leu Ala Lys  Tyr Gln Val 
    1040                 1045                 1050             


Ser Arg  Ile Glu Val Phe Lys  Ile Thr Leu Glu Ile  Glu Lys Asn 
    1055                 1060                 1065             


Ile Val  Asp Ala Tyr Pro Asn  Leu Pro Thr Asp Asn  Phe Arg Glu 
    1070                 1075                 1080             


Leu Leu  Gly Glu Trp Leu Asn  Ile Lys Val Asn Gln  Ser Glu Leu 
    1085                 1090                 1095             


Arg Cys  Phe Thr Gln Ile Leu  Val Ser Ile Arg Asn  Ala Phe Ala 
    1100                 1105                 1110             


His Asn  Gln Tyr Pro Arg Tyr  Cys Asp Glu Lys Phe  Gly Ser Ile 
    1115                 1120                 1125             


Asn Arg  Phe Asn Ile Ser Asn  Pro Asn Thr Ala Glu  Ser Asn Gly 
    1130                 1135                 1140             


Leu Asn  Ile Ala Ile Gln Leu  Leu Asp Leu Ala Thr  Thr Ile Lys 
    1145                 1150                 1155             


Ser Leu  Ile Ile Lys Glu Leu  
    1160                 1165 


<210>  2623
<211>  1124
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2623

Met Lys Ile Pro Gln Ile Ile Glu Asn Asn Lys His Leu Phe Gly Ala 
1               5                   10                  15      


Tyr Ser Thr Met Ala Leu Ser Asn Ile Arg Asn Ile Leu Asp His Ile 
            20                  25                  30          


Ala Thr Leu Ala Asp Ile Glu Asn Asp Phe Tyr Ser Asp Ser Asp Ser 
        35                  40                  45              


Tyr Trp Tyr His Pro Cys Ile Lys Ile Ile Asp Pro Arg Asn Asn Cys 
    50                  55                  60                  


Thr Asp Ala Ala Lys Ala Asp Phe Val Ile Glu Lys Ile Lys Ser His 
65                  70                  75                  80  


Phe Pro Phe Val Pro Ile Val Ala Glu Ala Gln Arg Gln Ser Asp Ile 
                85                  90                  95      


Leu Arg Ala Lys Lys Gln Leu Asp Ile Ala Val Arg Asn Arg Asp Tyr 
            100                 105                 110         


Gln Lys Gln Glu Glu Leu Lys His Arg Gln Lys Ser Leu Leu Ser Val 
        115                 120                 125             


Thr Asn Ala Asp Ile Tyr Arg Val Leu Asn Asn Met Leu Trp Val Leu 
    130                 135                 140                 


Ala Asn Tyr Arg Asn Gln Thr Val His Tyr Leu Ile Ser Asp Ile Lys 
145                 150                 155                 160 


Phe Glu Asp Gly Ser Asp Phe Leu Asn Tyr Asn Glu Gln Pro Leu Ser 
                165                 170                 175     


Arg Met Leu Asn Asn Tyr Phe Thr Ile Ala Leu Arg Asp Thr Ala Asn 
            180                 185                 190         


Lys Tyr Ser Tyr Ser Pro Glu Ala Leu Ser Phe Ile Gln Ser Ser Arg 
        195                 200                 205             


Tyr Lys Thr Glu Asn Arg Arg Lys Ile Leu Asp Thr Asp Phe Phe Leu 
    210                 215                 220                 


Ser Ile Gln His Asn Asn Ser Asp Thr Asn Pro Lys Asn Leu His Leu 
225                 230                 235                 240 


Ser Gly Val Gly Val Ala Leu Leu Ile Cys Leu Phe Leu Glu Lys Lys 
                245                 250                 255     


Tyr Val Asn Val Phe Leu Gln Lys Leu Pro Ile Tyr Gly Pro Tyr Lys 
            260                 265                 270         


Lys Gln Ser Met Glu Ala Asn Ile Ile Arg Gln Ser Phe Ser Ile His 
        275                 280                 285             


Thr Val Lys Leu Pro Lys Glu Arg Ile Val Ser Glu Lys Ser Asp Phe 
    290                 295                 300                 


Thr Ile Ala Leu Asp Met Leu Asn Glu Leu Lys Arg Cys Pro Lys Gln 
305                 310                 315                 320 


Leu Phe Ser Thr Leu Ser Tyr Ala Asp Gln Asn Ala Phe Arg Ile Val 
                325                 330                 335     


Ser Ser Asp Met Ser Asp Val Leu Gln Val Arg His Thr Asp Arg Phe 
            340                 345                 350         


Ala Gln Leu Ser Leu Glu Tyr Ile Asp Arg Arg Glu Leu Phe Ser Asp 
        355                 360                 365             


Ile Arg Phe His Leu Asn Met Gly Lys Leu Arg Tyr Leu Lys Thr Ala 
    370                 375                 380                 


Asp Lys His Cys Ile Asp Gly Val Ser Arg Val Arg Val Leu Glu Gly 
385                 390                 395                 400 


Lys Ile Asn Ala Phe Gly Arg Ile His Glu Phe Glu Ala Arg Arg Lys 
                405                 410                 415     


Glu Gln Gly Phe Val Glu Trp His Glu Gln Ala Ala Arg Leu Ile Lys 
            420                 425                 430         


Thr Asn Lys Asn Ile Glu Ile Arg Asp Phe Glu His Val Lys Arg Asp 
        435                 440                 445             


Asp Ala Thr Pro Asp Ser Tyr Pro Tyr Ile Ile Asp Thr Tyr Thr His 
    450                 455                 460                 


Tyr Leu Leu Glu Asn Asn Lys Ile Glu Met Arg Phe Gly Asp Tyr Leu 
465                 470                 475                 480 


Pro Lys Leu Val Lys Val Asp Asp Gln Lys Trp Thr Val Tyr Asn Glu 
                485                 490                 495     


Met Pro Thr Cys Cys Met Ser Ala Leu Glu Leu Pro Ala Met Met Phe 
            500                 505                 510         


His Met Met Leu Cys Gly Ser Glu Ala Thr Glu His Leu Ile Lys Ala 
        515                 520                 525             


Glu Val Glu Lys Tyr Lys Lys Leu Phe Gly Ala Met Ala Asn Gly Thr 
    530                 535                 540                 


Leu Ser Lys Glu Asn Ile Gly Asn Phe Glu Ile Ala Met Glu Asp Leu 
545                 550                 555                 560 


Pro Lys Lys Val Ile Asp Cys Val Asn Arg Lys Lys Ser Gly Lys Ser 
                565                 570                 575     


Phe Val Lys Gln Ile Lys Lys Glu Ile Ala Glu Met Leu Ala Asp Thr 
            580                 585                 590         


Asn Leu Arg Ile Val Arg Leu Lys Ser Asp Lys Arg Ser Val Ala Ser 
        595                 600                 605             


Thr Gln Asn Lys Met Gly Lys Arg Gly Phe Arg Ser Ile Gln Pro Gly 
    610                 615                 620                 


Lys Leu Ala Asp Trp Leu Ala Ala Asp Ile Val Lys His Gln Pro Ser 
625                 630                 635                 640 


Leu Phe Ser Gly Asp Asp Tyr Gly Thr Asp Arg Ile Thr Gly Met Asn 
                645                 650                 655     


Tyr Arg Val Met Gln Ser Thr Ile Ala Thr Phe Asn Ala Ala Thr Pro 
            660                 665                 670         


Glu His Ser Leu Asp Glu Leu Lys Arg Val Phe Ser Ala Ala Gln Leu 
        675                 680                 685             


Ile Gln Cys Gln Glu Arg Glu His Pro Phe Leu Gln Lys Ala Leu Asn 
    690                 695                 700                 


Arg Asn Pro Gln Asn Thr Ile Asp Phe Tyr Glu Phe Tyr Leu Gln Ala 
705                 710                 715                 720 


Lys Arg Ala Tyr Tyr Gln Ser Leu Arg Gln Ser Ile Glu Asn Gly Glu 
                725                 730                 735     


Asp Val Lys Leu Pro Tyr Leu Asn Pro Asp Arg Asn Lys Trp Val Arg 
            740                 745                 750         


Arg Gly Ala Ser Phe Tyr Ser Thr Met Gly Asp Ile Tyr Leu Glu Asp 
        755                 760                 765             


Met Pro Ile Glu Leu Pro Arg Gln Met Phe Asp Lys Glu Ile Lys Lys 
    770                 775                 780                 


Ala Leu Ala Gln Leu Pro Ser Met Lys Gly Val Asp Met Lys Gln Ser 
785                 790                 795                 800 


Asn Val Thr Phe Leu Ile Ala Glu Tyr Leu Lys Arg Glu Leu Lys Asp 
                805                 810                 815     


Asp Phe Gln Pro Phe Tyr Gln Trp Asn Arg Asn Tyr Arg Phe Thr Asp 
            820                 825                 830         


Met Met Ile Cys Glu Glu Asn Cys Asp Thr Lys Ala Leu Ala Ser Lys 
        835                 840                 845             


Phe Ile Pro Leu Glu Leu Arg Glu Glu Ile Trp Glu Lys Arg Gly Glu 
    850                 855                 860                 


Leu Lys Asp Ala Tyr Lys Arg Trp Ala Phe Gly Arg Leu Asn Lys Asn 
865                 870                 875                 880 


Pro Asp Ile Lys Arg Leu Ser Pro Ala Glu Lys Asp Glu Leu Leu Glu 
                885                 890                 895     


Lys Arg Ile Ala Lys Cys Arg Asn Glu Tyr Gln Lys Ser Glu Lys Ile 
            900                 905                 910         


Ile Arg Arg Tyr Lys Val Gln Asp Val Leu Met Phe Met Met Val Lys 
        915                 920                 925             


Ser Met Phe Ala Gln Gly Val Phe Thr Ala Glu Ser Lys Glu Phe Ala 
    930                 935                 940                 


Leu Ser Thr Ile Thr Pro Asp Ala Glu Arg Gly Ile Leu Ser Glu Val 
945                 950                 955                 960 


Val Pro Ile Asp Phe Lys Phe Ser Ile Asp Gly Lys Thr Tyr Thr Ile 
                965                 970                 975     


His Ser Asn Gly Met Lys Ile Lys Asn Tyr Gly Asp Phe Tyr Lys Leu 
            980                 985                 990         


Ile Asn Asp Lys Arg Met Lys Ser  Leu Leu Asn Ile Val  Thr His Ser 
        995                 1000                 1005             


Thr Ile  Glu Lys Asp Leu Leu  Glu Lys Glu Phe Ser  Thr Tyr Asp 
    1010                 1015                 1020             


Asp Lys  Arg Pro Glu Ala Val  Glu Ile Ile Phe Glu  Phe Glu Lys 
    1025                 1030                 1035             


Ala Ala  Tyr Glu Lys His Pro  Glu Leu Lys Glu Leu  Leu Thr Pro 
    1040                 1045                 1050             


Glu Arg  Lys Phe Asp Phe Arg  Ala Leu Leu Glu Glu  Leu Gln Ala 
    1055                 1060                 1065             


Lys Ser  Asp Leu Ser Gln Ile  Asp Ala Arg Tyr Leu  Ser Gln Ile 
    1070                 1075                 1080             


Arg Asn  Ala Phe Asn His Asn  Ala Tyr Pro Arg Asn  Leu Lys Ile 
    1085                 1090                 1095             


Thr Ser  Asn Ile Pro Glu Ile  Ala Gln Glu Met Val  Asn Ile Phe 
    1100                 1105                 1110             


Arg Ile  Thr Asp Pro Tyr Lys  Lys Gly Lys Lys 
    1115                 1120                 


<210>  2624
<211>  1167
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2624

Met Asn Lys Ala Ile Phe Gly Ala Tyr Leu Asn Ala Ala Gln His Asn 
1               5                   10                  15      


Ala Tyr Met Ile Leu Asn His Ile Lys Asp Leu Val Thr Leu Lys Asp 
            20                  25                  30          


Lys Asn Asn Thr Ala Gly Ala Asp Val Glu Glu Ser Arg Leu Asp Asn 
        35                  40                  45              


Ile Asn Ile Leu Gln Leu Lys Asn Ala Pro Glu Lys Ile Ala Tyr Thr 
    50                  55                  60                  


Leu Lys Leu Leu Tyr Leu His Phe Pro Phe Leu Gly Met Leu Val Pro 
65                  70                  75                  80  


Glu Asn Ile Asn Ser Val Glu Asn Asn Tyr Glu Lys Val Ala Arg Ile 
                85                  90                  95      


Leu Lys Lys Ala Leu Val Arg Leu Asn Gln Glu Arg Asn Gln Tyr Ser 
            100                 105                 110         


His Tyr Glu Thr Gln Thr Leu Lys Thr Glu Ser His Phe Val Leu Ala 
        115                 120                 125             


Ser Thr Gln Lys Asp Leu Asp Leu Asp Glu Leu Arg Ser Thr Phe Leu 
    130                 135                 140                 


Asn Trp Phe Asn Leu Asp Asn Pro Asn Lys Glu Arg Ala Phe Ala Arg 
145                 150                 155                 160 


Tyr Pro Phe Met Asp Gly Glu Ala Arg Asn Phe Met Gly Leu His Ile 
                165                 170                 175     


Ala Lys Asn Ser Leu Trp Lys Asn Ser Ser Glu Ala Gly Lys Asp Phe 
            180                 185                 190         


Ser Glu Lys Gly Leu Ile Tyr Phe Leu Cys Leu Phe Leu Glu Arg Lys 
        195                 200                 205             


Gln Ala Tyr Leu Leu Leu Asn Ser Ile Gln Gly Phe Lys Gly Ser Lys 
    210                 215                 220                 


Gly Asn Lys Phe Arg Ala Val Arg Glu Met Tyr Ala His Asn Cys Cys 
225                 230                 235                 240 


Lys Leu Pro Gln Pro Arg Leu Asp Ser Ser Asp Ile Leu Leu Asp Met 
                245                 250                 255     


Leu Asn Glu Leu Asn Arg Cys Pro Lys Asp Leu Phe Gln Val Leu Gly 
            260                 265                 270         


Glu Thr Asp Gln Gln Arg Phe Met Ser Ala Ile Asp Asn Ala Ser Ala 
        275                 280                 285             


Val Val Lys Arg Gln Asp Asp Asn Gly Glu Leu Leu Glu Tyr Glu Lys 
    290                 295                 300                 


Arg Ile Arg His Gln Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe 
305                 310                 315                 320 


Asp Asp Thr Asn Ala Phe Pro Arg Leu Arg Phe Gln Leu Tyr Ile Gly 
                325                 330                 335     


Lys Leu Leu Gln Lys Thr Tyr Asp Lys Ala Leu Gln Gly Glu Thr Tyr 
            340                 345                 350         


Gln Arg Gln Ile Ala Lys Glu Ile Tyr Ala Phe Gly Lys Leu Ser Glu 
        355                 360                 365             


Phe Leu Gly Thr Gln Pro Thr Lys His Pro Leu Leu Lys Asn Met Thr 
    370                 375                 380                 


Val Tyr Glu Gln His Thr Ile Asp Thr Ala Thr Gly Ala Val Ile Asn 
385                 390                 395                 400 


Asn Pro Asn Ala Pro Glu Ile Gly Gln Ile Val Gln Phe Ser Pro Gln 
                405                 410                 415     


Tyr Asn Phe Gly Thr Asn Lys Ile Met Leu Lys Ile Gly Lys Glu Thr 
            420                 425                 430         


Thr Val Asp Ser Lys Ala Leu Glu Tyr Arg Arg Gly Glu Lys Gly Val 
        435                 440                 445             


Val Leu Lys Asp Lys Met Lys Ile Lys Lys Ile Glu Pro Glu Glu Lys 
    450                 455                 460                 


Glu Ala Ile Leu Ser Thr His Glu Leu Pro Asn Leu Phe Leu Tyr His 
465                 470                 475                 480 


Tyr Leu Tyr Lys Gln Gly His Leu Thr Ser Thr Val Glu Ser Phe Ile 
                485                 490                 495     


Glu Lys Tyr Ile Asp Thr Phe Arg Lys Phe Ile Lys Ser Val Gln Thr 
            500                 505                 510         


Lys Gln Phe Leu Pro Leu Glu Lys Ser Ala Phe Lys Arg Arg Ser Ile 
        515                 520                 525             


Ser Tyr Lys Asp Arg Lys Glu Ala Thr Ile Lys Lys Ala Pro Gln Thr 
    530                 535                 540                 


Gly Arg Glu Pro Tyr Asn Asp Lys Asn Phe Glu Glu Leu Lys Asp Arg 
545                 550                 555                 560 


Lys Thr Ala Leu Gln His Arg Leu Asp Asn Ser Asp Phe Lys Gly Leu 
                565                 570                 575     


Tyr Trp Ser Tyr Leu Pro Asp Glu Ile Val Asn Tyr Leu Leu Asn Thr 
            580                 585                 590         


Gln Pro Thr Asp Tyr Lys Thr Val Val Leu Ala Lys Ile Asp Glu Leu 
        595                 600                 605             


Lys Asp Gln Thr Asn Glu Leu Lys Gln Gln Phe Lys Arg Ile Asn Lys 
    610                 615                 620                 


Arg Lys Ala Phe Phe Glu Glu Glu Gln Glu Glu Asn Pro Thr Asn Asp 
625                 630                 635                 640 


His Thr Ala Thr Phe Ser Thr Gly Leu Arg Val Gly Glu Ile Ala Thr 
                645                 650                 655     


Trp Leu Ala Lys Asp Ile Ile Phe Leu Lys Pro Tyr Gln Lys Asp Val 
            660                 665                 670         


Lys Asn Tyr Gly Lys Pro Asn Asn Asp Gln Tyr Asn Arg Leu Gln Thr 
        675                 680                 685             


Leu Leu Ala Leu Tyr Pro Leu Tyr Lys Asp Glu Leu Pro Lys Phe Phe 
    690                 695                 700                 


Glu Glu Leu His Leu Ile Gly Gly Lys Ser Thr Glu Asn His Pro Phe 
705                 710                 715                 720 


Leu Ser Gln Asn Leu Pro Asn Ser Leu Tyr Asp Phe Tyr Gln Asn Tyr 
                725                 730                 735     


Ile Asp Ala Lys Leu Lys Trp Leu Ile Gln Leu His Thr Asp Ile Asp 
            740                 745                 750         


Gly Val Lys Arg Lys Asp Lys Ala Thr Gln Ser Ile Lys Thr Val Lys 
        755                 760                 765             


Glu Gly Leu Asn Pro Thr Gln Ile Glu Asn Leu Tyr Ser His Leu Phe 
    770                 775                 780                 


Gly Lys Ile Ser Gln Val Glu Thr Asn Ile Glu Ser Lys Lys Tyr Asp 
785                 790                 795                 800 


Thr Leu Pro Ile Ala Leu Pro Val Gly Leu Phe Asn Ala Ala Ile Leu 
                805                 810                 815     


Glu Gly Met Gln Arg Lys Gly Ile Ala Leu Ser Glu Lys Asp Asn Thr 
            820                 825                 830         


Leu Phe Ala Leu Lys Asn Leu Leu Gln Asn Asp Thr Gln Glu Phe Tyr 
        835                 840                 845             


His Tyr Pro Arg Arg Tyr Glu Thr Thr Gln Glu Ile Leu Gln Pro Phe 
    850                 855                 860                 


Leu Thr His Ser Gly Ser Ala Cys Lys Asp Leu Ala Glu Arg Glu Lys 
865                 870                 875                 880 


Leu Met Glu Ser Leu Lys Asn Glu Ile Asn Arg Leu Gly Lys Ser Thr 
                885                 890                 895     


Asn Glu Glu Lys Leu Ile Leu Arg Arg Thr Leu Val Asn Phe Arg Ser 
            900                 905                 910         


Arg Val Leu Glu Lys Glu Gln Thr Ile Arg Phe Thr Gln Gln Gln Asp 
        915                 920                 925             


Arg Cys Leu Trp Leu Met Cys Gln Glu Leu Thr Asn Tyr Arg Lys Glu 
    930                 935                 940                 


Lys Thr Gln Glu Gly Ile Gln Leu Asp Phe Thr Asn Thr Ser Leu Gln 
945                 950                 955                 960 


Lys Leu Glu Glu Leu Leu Asp Thr Asn Lys Glu Met Lys Leu Gln Val 
                965                 970                 975     


Tyr Ile Tyr Lys Thr Lys Gln Ala Ile Gly Ile Ile Thr Asp Thr Leu 
            980                 985                 990         


Pro Ile Arg Arg Tyr Gly Asp Leu  Arg Arg Phe Ala Lys  Asn Arg Gln 
        995                 1000                 1005             


Leu Pro  Asn Leu Tyr Asp Tyr  Phe Tyr Asp Glu Asn  Gln His Gln 
    1010                 1015                 1020             


Asn Gly  Asn Leu Pro Thr Phe  Ser Pro Gln Asn Leu  Gln Asp Ala 
    1025                 1030                 1035             


Leu Glu  Phe Leu Glu Lys Asn  Arg Pro Ser Ile Leu  Gln Lys Ala 
    1040                 1045                 1050             


Leu Asp  Leu Glu Glu Val Ile  Phe Ser Asn Tyr Glu  Val Glu Phe 
    1055                 1060                 1065             


Val Ala  Tyr Lys Ala Ala Asn  Ser Thr Lys Thr Asp  Pro Asp His 
    1070                 1075                 1080             


Asn Ile  Phe Ile Glu Tyr Leu  Phe Ser Lys Leu Pro  Glu Thr Thr 
    1085                 1090                 1095             


Leu Thr  Gln Ile Ala Gly Ala  Asn Thr Glu Ala Lys  Lys Ile Phe 
    1100                 1105                 1110             


Lys Leu  Arg Asn His Ile Leu  His Asn Glu Val Pro  Pro Lys Glu 
    1115                 1120                 1125             


Tyr Ile  Gly Asn His Leu Thr  Gln His Leu Gly Lys  Asn Pro Glu 
    1130                 1135                 1140             


Thr Pro  Leu Gln Val Thr Glu  Phe Ile Ile Ala His  Thr Ile Arg 
    1145                 1150                 1155             


Ile Tyr  Glu Gln Leu Ala Ala  Ala Val 
    1160                 1165         


<210>  2625
<211>  1131
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2625

Met Glu Lys Thr Ile Glu Asn Gln Thr Gln Ser Lys Arg Thr Leu Asn 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Asp Glu Glu Lys Ile Thr Thr Ser Phe Leu Val Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Arg Gln Ser Leu Val Tyr Ser Asn Leu Thr 
65                  70                  75                  80  


Arg Tyr Met His Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Asp 
                85                  90                  95      


Asp Glu Arg Asp Lys Ala Glu Asn Tyr Gly Lys Asp Phe Gly Asn Leu 
            100                 105                 110         


Thr Asp Thr Leu Lys Glu Ile Phe Lys Glu Leu Asn Glu Phe Arg Asn 
        115                 120                 125             


Asp Tyr Ser His Tyr Tyr Ser Thr Glu Lys Lys Asp Lys Arg Lys Thr 
    130                 135                 140                 


Ile Val Ser Asp Lys Leu Lys Asn Phe Leu Asn Ile Asn Tyr Thr Arg 
145                 150                 155                 160 


Ala Ile Lys Tyr Thr Lys Ser Arg Phe Ile Asn Val Phe Ser Asp Asn 
                165                 170                 175     


Asn Phe Cys Leu Ala Glu Glu Ala Lys His Val Glu Asn Asp Asn Thr 
            180                 185                 190         


Ile Thr Gln Asp Gly Ile Val Phe Phe Thr Ser Met Phe Leu Asp Arg 
        195                 200                 205             


Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile Ile Gly Leu Lys Gly Thr 
    210                 215                 220                 


Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Thr Leu Met Ala Phe Cys 
225                 230                 235                 240 


Val Asn Leu Pro His Asp Lys Phe Val Ser Glu Asn Ser Glu Gln Gln 
                245                 250                 255     


Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu 
            260                 265                 270         


Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln His Phe Leu Pro Lys Leu 
        275                 280                 285             


Asp Asp Glu Gln Ile Asp Asn Val Leu Glu Asn Ser Val Pro Tyr Thr 
    290                 295                 300                 


Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn Ile Thr Lys Lys Val Arg 
305                 310                 315                 320 


Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu Lys Phe Ile Asp Gln Lys 
                325                 330                 335     


Lys Leu Phe Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val 
            340                 345                 350         


Leu Asp Glu Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Lys Arg Thr 
        355                 360                 365             


Val Thr Glu Asn Thr Lys Ala Phe Gly Met Leu Gln Asp Leu Asn Asp 
    370                 375                 380                 


Glu Glu Asn Val Leu Asn Lys Ile Asn Thr Gly Glu Ser Lys Ala Lys 
385                 390                 395                 400 


Phe Asp Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Thr Lys Asn 
            420                 425                 430         


Thr Asp Asn Lys Ile Lys Ser Asn Leu Leu Gln Pro Leu Pro Glu Ala 
        435                 440                 445             


Phe Leu Ser Ile Asn Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
    450                 455                 460                 


Glu Gln Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn 
465                 470                 475                 480 


Asn Ser Lys Ile Leu Asn Lys Glu Phe Ile Lys Ala Ile Lys Leu Lys 
                485                 490                 495     


Leu Asn Asp Leu Asp Val Phe Tyr Lys Arg Ser Gln Gly Arg Lys Gln 
            500                 505                 510         


Lys His Ala Tyr Leu Thr Lys Asp Lys Lys Tyr Asp Asn Glu Lys Ile 
        515                 520                 525             


Asn Glu Leu Lys Asn Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu 
    530                 535                 540                 


Tyr Asn Leu Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp 
545                 550                 555                 560 


Leu Asn Ile Ala Asp Val Gln Ala Lys Asn Ala Ile Ser Asp Arg Ile 
                565                 570                 575     


Lys Leu Met Lys Arg Asp Cys Ile Asn Arg Leu Lys Ser Met Lys Lys 
            580                 585                 590         


Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp 
        595                 600                 605             


Ile Val Asp Met Ile Ile Asp Glu Glu Lys Lys Lys Lys Ile Thr Ser 
    610                 615                 620                 


Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Lys 
625                 630                 635                 640 


Glu Lys Lys Glu Leu Phe Ile Leu Ile Cys Asn Asn Glu Leu Lys Leu 
                645                 650                 655     


Asn Asp Asp Asp Gly His Pro Phe Phe Lys Asn Ile Asn Phe Ser Asn 
            660                 665                 670         


Tyr Lys Tyr Thr Ser Glu Ile Tyr Gln Lys Tyr Leu Glu Glu Lys Gly 
        675                 680                 685             


His Lys Met Val Lys Glu Tyr Asn Pro Arg Lys Glu Asn Tyr Val Glu 
    690                 695                 700                 


Lys Asp Lys Ser Trp Leu Glu Ile Asn Phe Tyr Lys Lys Glu Trp Asn 
705                 710                 715                 720 


Glu Asn Ala Lys Lys Asp Leu Thr Val Val Lys Leu Pro Asp Asp Lys 
                725                 730                 735     


Ser Lys Ile Pro Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser 
            740                 745                 750         


Phe Glu Asn Trp Phe Lys Tyr Val Thr Asn Gly Lys Glu Thr Thr Asp 
        755                 760                 765             


Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp Glu Thr Leu 
    770                 775                 780                 


Lys Glu Leu Leu Lys Lys Glu Leu Ser Lys Asn Asn Ile Glu Phe Lys 
785                 790                 795                 800 


Glu Glu Asp Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Asp Lys Cys 
                805                 810                 815     


Arg Asn Asp Lys Thr Gln Lys Phe Tyr Ser Ala Glu Arg Glu Tyr Thr 
            820                 825                 830         


Phe Glu Glu Glu Lys Leu Asn Phe His Ile Asn Thr Lys Ser Lys Phe 
        835                 840                 845             


Glu Glu Tyr Ile Asn Pro Glu Phe Ala Glu Lys Val Phe Arg Leu Lys 
    850                 855                 860                 


Asn Gln Asn Arg Glu Lys Asp Asn Ile Ser Gly Arg Arg Leu Pro Pro 
865                 870                 875                 880 


Leu Lys Met Lys Glu Val Thr Lys Asn Met Val Lys Arg Ile Gly Asn 
                885                 890                 895     


Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Leu Met Leu 
            900                 905                 910         


Leu Met Phe Glu Lys Leu Val Asp Asn Asn Leu Lys Leu Lys Leu Glu 
        915                 920                 925             


Asn Val Asp Lys Leu Leu Asn Glu Ser Ile Glu Ile Asn Gln Ser Ile 
    930                 935                 940                 


Ser Gly Lys Leu Ser Phe Asp Asp Ser Gly Asp Asn Glu Asn Lys Lys 
945                 950                 955                 960 


Asp Arg Ala Ile Ile Cys Arg Asn Ile Thr Glu Thr Arg Lys Arg Lys 
                965                 970                 975     


Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Glu Glu Glu  Asn Ile Pro Ile Glu  Lys Ile Lys 
        995                 1000                 1005             


Ile Glu  Leu Asp Thr Tyr Ser  Lys Ala Lys Asp Val  Val Phe Asp 
    1010                 1015                 1020             


Leu Ile  Phe Asp Leu Glu Arg  Ala Ile Ile Asn Lys  Asp Glu Asn 
    1025                 1030                 1035             


Arg Ile  Lys Glu Leu Asn Lys  Asp Lys Asn Gly Val  Ile Gln Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Phe Trp Leu  Leu Glu Lys 
    1055                 1060                 1065             


Asn Leu  Ile Thr Glu Gln Glu  Phe Thr Phe Met Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Thr  Phe Ser His Asn Gln  Phe Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Leu Phe  Ile Lys Asn Trp Asn  Glu Asn Glu Phe Ala  Lys Gln Ile 
    1100                 1105                 1110             


Leu Asn  Val Tyr Asn Gln Lys  Asn Asn Asn Leu Ile  Lys Ser Ile 
    1115                 1120                 1125             


Lys Asp  Ile 
    1130     


<210>  2626
<211>  1104
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2626

Met Glu Thr Asn Glu Asn Gln Lys Asn Asn Ser Lys Thr Leu Asp Ser 
1               5                   10                  15      


Asp Lys Tyr Tyr Phe Ala Ala Tyr Leu Asn Met Ala Arg His Asn Ala 
            20                  25                  30          


Phe Ile Thr Leu Ala His Ile Thr Arg Ile Leu Gly Lys Asn Pro Ala 
        35                  40                  45              


Gly Glu Asp Gln Leu Ala Glu Met Tyr Ala Ile Lys Ile Phe Asn Pro 
    50                  55                  60                  


Val Asn Asn Ser Leu Ser Glu Asp Ile Leu Lys Ala Lys Lys Leu Ile 
65                  70                  75                  80  


Asp Lys His Phe Pro Phe Val Lys Tyr Leu Val Asn Ile Asn Asp Ser 
                85                  90                  95      


Asp Pro Glu Val Tyr Ile Ala Glu Lys Tyr His Lys Val Leu Asn Gln 
            100                 105                 110         


Tyr Ser Thr Leu Leu Asn Asp Tyr Arg Asn Tyr Tyr Thr His Thr Ala 
        115                 120                 125             


Ser Ala Ala Lys Val Asp Leu Gln Pro Asp Phe Asn Asn Gly Leu Glu 
    130                 135                 140                 


Ser Ile Phe Asp Leu Ala Val Asn Glu Val Val Lys Arg Phe Thr Leu 
145                 150                 155                 160 


Lys Glu Glu Glu Ile Asn His Leu Arg Arg Lys Ser Pro Glu Asn Thr 
                165                 170                 175     


Glu Ile Asp Asn Ser Thr Phe Lys Tyr Arg Phe Arg Arg Lys Ser Leu 
            180                 185                 190         


Pro Pro Ala Phe Asn Glu Asn Gly Met Ala Phe Phe Ile Cys Leu Phe 
        195                 200                 205             


Leu Glu Lys Asn Tyr Ser Tyr Leu Phe Leu Lys Gln Ile Thr Gly Phe 
    210                 215                 220                 


Lys Lys Asp Gly Thr Pro Gly Phe Arg Ala Ser Leu Glu Ala Tyr Thr 
225                 230                 235                 240 


Val Tyr Arg Thr Arg Ile Pro Lys Ile Arg Ile Asp Ala Glu Gln Asn 
                245                 250                 255     


Arg Glu Met Thr Leu Ala Met Asp Met Leu Gly Glu Leu Lys Lys Cys 
            260                 265                 270         


Pro Arg Glu Leu Tyr Asp Val Leu Gln Pro Glu Tyr Asp Asn Lys Phe 
        275                 280                 285             


Arg Ala Lys Leu Asn Ser Asp Asp Gly Glu Asn Glu Glu Asp Asp Tyr 
    290                 295                 300                 


Glu Thr Glu Asn Leu Phe Leu Arg Asn Gly Ser Arg Phe Ser Tyr Leu 
305                 310                 315                 320 


Ala Leu Ser Phe Ile Asp Thr Asn Asn Leu Leu Pro Gly Tyr Ser Phe 
                325                 330                 335     


His Ile Asp Leu Gly Asn Tyr Tyr Phe Arg Phe Tyr Ser Lys Met Gly 
            340                 345                 350         


Ala Asp Gly Ile Glu Arg Lys Arg Asn Ile Lys Lys His Leu Leu Thr 
        355                 360                 365             


Tyr Gly Asn Leu Val Glu Ala His Gln Gln Lys Lys Val Gln Trp Gly 
    370                 375                 380                 


Leu Leu Glu Lys Glu Asn His Glu Ile Pro Glu Asn Asn Glu Glu Pro 
385                 390                 395                 400 


Tyr Ile Thr Asn Thr Tyr Pro His Tyr His Ile Gln Asn Asn Gln Val 
                405                 410                 415     


Gly Leu Phe Ser Trp Asn Asn Ile Lys Thr Glu Leu Pro Glu Leu Lys 
            420                 425                 430         


Gly Lys Asp Thr Lys Thr Lys Ala Pro Asp Ile Trp Leu Ser Thr Tyr 
        435                 440                 445             


Glu Leu Pro Ala Ile Ile Phe Tyr Ala Leu Leu Cys Lys Lys Gln Ala 
    450                 455                 460                 


Ala Ile Pro Pro Glu Thr Ile Ile Ala Asn His Ile Glu Lys Ile Lys 
465                 470                 475                 480 


Gln Leu Phe Ser Asp Ile His Thr Gly Ile Cys Lys Pro Lys Leu Ser 
                485                 490                 495     


Gln Met Asn Ala Asp Glu Tyr Ile Lys Gln Phe Glu Ser His Tyr Val 
            500                 505                 510         


Ser Leu Ser Asp Ile Pro Lys Pro Leu Lys Glu Tyr Leu Leu Gly Glu 
        515                 520                 525             


Thr Phe Pro Asp Lys Ala Phe Glu Asp Tyr Ala His Asp Met Ile Lys 
    530                 535                 540                 


Lys Leu Phe Asp Asp Thr Ala His Arg Leu Lys Gln Leu Asp Lys Gln 
545                 550                 555                 560 


Ile Ile Lys Asp Glu Glu Ser Lys Pro Gly Val Asn Gly Glu Asp Lys 
                565                 570                 575     


Phe Asn Ser Thr Tyr Asp Asn Met Lys Ala Gly Arg Met Ala Ala Phe 
            580                 585                 590         


Leu Ala Thr Asp Met Leu Met Met Gln Pro Ser Val Ser Val Asn Glu 
        595                 600                 605             


Leu Gly Ile Lys Asp Gly Lys Asp Lys Ala Thr Gly Phe Asn Phe Gln 
    610                 615                 620                 


Ile Leu Gln Ser Cys Leu Ala Leu Tyr Gly Ala Asn His His Lys Leu 
625                 630                 635                 640 


Tyr His Ile Phe Glu Asn Cys Lys Leu Ile Asn Ser Pro Ile Pro His 
                645                 650                 655     


Pro Phe Leu Lys Asp Ile Asn Leu Pro Thr Leu Asp Thr Leu Ser Ala 
            660                 665                 670         


Phe Tyr Lys Gln Tyr Leu Ile Glu Arg Lys Lys Tyr Leu Gly Ile Cys 
        675                 680                 685             


Thr Leu Glu Lys Asn Tyr His Ala Tyr Tyr Phe Leu Lys Pro Gly Glu 
    690                 695                 700                 


Arg Arg Trp His Glu Arg Asn Asp Glu Tyr Tyr Arg Gln Leu Ala His 
705                 710                 715                 720 


Asn Tyr Leu Asn Gly Phe Gly Lys Glu Pro Asn Lys Leu Gly Phe Asn 
                725                 730                 735     


Leu Pro Arg Ser Leu Phe Thr Pro Phe Ile Lys Ser Trp Phe Ala Arg 
            740                 745                 750         


Phe Gly Asn Thr Glu Met Lys Leu Leu Ile Lys Glu Glu Ser Gln Gln 
        755                 760                 765             


Lys His Asn Ala Ala Phe Leu Ile Thr Lys Tyr Phe Glu Leu Asn Leu 
    770                 775                 780                 


Asn Asp Lys Val Gln Pro Phe Tyr Asp Phe Pro Arg Ser Tyr Phe Phe 
785                 790                 795                 800 


Thr Asp Lys Tyr Phe Ser Leu Gln Lys Ser Asn Lys Trp Pro Glu Glu 
                805                 810                 815     


Phe Thr Thr Glu Phe Leu Ser Phe Ser Glu Leu Cys Asn Lys Ser Ala 
            820                 825                 830         


Asp Phe Glu Lys Phe Tyr Lys Asp Leu Gly His His Ser Tyr Leu Asp 
        835                 840                 845             


Asp Lys Gln Arg Gln Thr Leu His Lys Asp Tyr His Asn Tyr Leu Lys 
    850                 855                 860                 


Asn Glu Lys Leu Ile Arg Leu Ala Gln Thr Thr Asp Met Val Leu Phe 
865                 870                 875                 880 


Met Ala Val Gln His Ile Phe Glu Lys Leu Lys Val Ala Asp Thr Glu 
                885                 890                 895     


Glu Phe Lys Leu Ser Ala Ile Gln Thr Pro Asp Thr Ser Asp Ile Leu 
            900                 905                 910         


Ser Leu Gln Cys Pro Phe Ser Leu Asn Ile Ala Val Tyr His Thr Asp 
        915                 920                 925             


Glu Lys Gly Asn Val Lys Arg Lys Glu Thr Pro Leu Ala Tyr Lys Lys 
    930                 935                 940                 


Ile Thr Gln Thr Asp Leu Lys Ile Lys Asn Phe Gly Asp Phe Met Arg 
945                 950                 955                 960 


Phe Thr Ala Asp Arg Arg Leu Asn Glu Leu Leu Lys Tyr Leu Pro Gln 
                965                 970                 975     


Glu Glu Val Ser Arg Ala Asp Leu Gln Arg Glu Leu Glu Glu Tyr Asp 
            980                 985                 990         


Thr Cys Arg Leu Ala Val Ala Lys  Ile Ile His Thr Phe  Glu Asn Lys 
        995                 1000                 1005             


Met Ile  Leu Arg Phe Ser Asn  Glu Met Asn Ala Met  Leu Thr Gln 
    1010                 1015                 1020             


His Ser  Tyr Ile Glu Phe Lys  Glu Ile Ser Lys Leu  Phe Tyr Thr 
    1025                 1030                 1035             


Ala Phe  Thr Glu His Leu Ala  Asp Cys Ile Lys Leu  Glu Ser Ile 
    1040                 1045                 1050             


Arg Asn  Ala Phe Met His Asn  Gln Tyr Pro Arg Pro  Glu Asp Val 
    1055                 1060                 1065             


Gly Leu  Ala Glu Val Ser Phe  Pro Gly Ile Ala Leu  Gln Leu Cys 
    1070                 1075                 1080             


Gln Gln  Ala Glu Asn Val Val  Gln Ile Phe Thr Gln  Lys Leu Thr 
    1085                 1090                 1095             


Leu Ile  Thr Asn Thr Gln 
    1100                 


<210>  2627
<211>  1219
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2627

Met Tyr Asn Phe Phe Glu Lys Ser Asp Lys Tyr Phe Phe Ala Gly Leu 
1               5                   10                  15      


Phe Asn Thr Ala Leu Asp Asn Phe Gln Glu Ala Leu Glu Glu Val Tyr 
            20                  25                  30          


Ser Arg Val Asn Gly Gly Ile Gly Ala Glu Ala Ile Glu Phe Pro Asp 
        35                  40                  45              


Asn Thr Val Ser Leu Ile Asn Lys Leu Phe Pro Arg Lys Lys Ala Gly 
    50                  55                  60                  


Met Ser Val Lys Val Thr Leu Phe Glu Ile Glu Arg Asn Leu Lys Leu 
65                  70                  75                  80  


Leu Val Lys Asn Val Arg Thr Phe Glu Leu Leu Asn Val Phe Tyr Glu 
                85                  90                  95      


Lys Leu Ile Lys Asn Gln Lys Glu Gly Lys Val Ala Asp Pro Leu Ser 
            100                 105                 110         


Ile Asp Tyr Arg Glu Phe Val Asn Arg Ala Ile Leu Thr Leu Trp His 
        115                 120                 125             


Val Ile Asn His Arg Arg Asn Phe Tyr Thr His Leu Asn Ser Ile Asp 
    130                 135                 140                 


Asp Phe Thr Phe Tyr Arg Phe Gly Asn Ser Glu Asp Ala Asp Leu Glu 
145                 150                 155                 160 


Trp Gly Lys Glu Phe Leu Phe Arg Tyr Leu Asp Phe Val Leu Leu Arg 
                165                 170                 175     


Asn Ala His Asp Ile Lys Asn Asp Arg Met Lys Asn Pro Asn Val Arg 
            180                 185                 190         


Ile Phe Leu Glu Lys Lys Pro Phe Phe Lys Asp Asp Lys Asn His Ile 
        195                 200                 205             


Ala Gln Asn His Phe Lys Lys Leu Gln Thr Lys Tyr Glu Asn Ser Asn 
    210                 215                 220                 


Asn Gln Asn Asp Lys Lys Lys Ile Arg Lys Val Ser Asn Glu His Lys 
225                 230                 235                 240 


Ser Gly Phe Ala Phe Asn Ser Thr Thr Lys Arg Phe Ile Phe Glu His 
                245                 250                 255     


His Asp Lys Ser Lys Gln Val Leu Ser Thr Ser Leu Lys Lys Ser Lys 
            260                 265                 270         


His Ser Lys Asn Glu Ser Ser Arg Leu Thr Arg Glu Gly Leu Ile Gly 
        275                 280                 285             


Leu Leu Cys Met Leu Leu Asn Lys Gly Gln Ala Gln Ile Leu Phe Asp 
    290                 295                 300                 


Asn Ile Ala Tyr Thr Glu Asn Ser Thr Asp Thr Lys Leu Gln Lys Leu 
305                 310                 315                 320 


Val Ser Arg Trp Val Phe Thr Thr Arg Ser Tyr Lys Asn Val Lys Ser 
                325                 330                 335     


Leu His Tyr Ser Asp Tyr Glu Asp Asp Gly Phe Leu Leu Gln Leu Val 
            340                 345                 350         


Asn Glu Leu Ser Lys Cys Pro Lys Glu Leu Tyr Glu Gln Leu Asn Glu 
        355                 360                 365             


Asn Asp Lys Ala Glu Phe Leu Glu Ala Ile Asp Tyr Asn Ile Ser Glu 
    370                 375                 380                 


Glu Gln Ala Asn Tyr Asp Gly Asp Gly Asp Thr Asn Tyr Glu Val Ile 
385                 390                 395                 400 


Arg Lys Arg Tyr Glu Asn Lys Phe Pro Tyr Phe Ala Ile Arg Phe Leu 
                405                 410                 415     


Asp Glu Lys Val Asp Phe Pro Thr Leu Lys Phe His Val Asn Val Gly 
            420                 425                 430         


Ser Phe Lys Arg Asn Thr Gln Gln Lys Glu Tyr Pro Asn Ser Asp Tyr 
        435                 440                 445             


Ser Pro Asn Arg Thr Ile Asn Glu Asn Leu Ala Val Phe Gln Lys Leu 
    450                 455                 460                 


Ser Ile Val Ala Asp Lys Lys Arg Ser Tyr Leu Glu His Pro Asn Phe 
465                 470                 475                 480 


Gln Asp Glu Lys Arg Arg Glu Ser Glu Glu Asn Thr Gly Asn Ile Trp 
                485                 490                 495     


Lys Glu Tyr Pro Lys Pro Ser Tyr Arg Tyr His Lys Asn Asn Ile Pro 
            500                 505                 510         


Ile Trp Leu Asp Val Ser Ser Cys Asp Ala Leu Lys Asn Ile Glu Leu 
        515                 520                 525             


Gly Asn Tyr Ser Arg Gly Asn Glu Gln Glu Gly Val Leu Arg Thr Ser 
    530                 535                 540                 


Gly Arg Tyr Asn Lys His Arg Ile Leu Gln Leu Met Phe Leu Gln His 
545                 550                 555                 560 


Asp Ile Lys Arg Pro Val Ala Leu Leu Ser Phe Asn Glu Leu Pro Ser 
                565                 570                 575     


Leu Ile His Glu Ile Leu Val Lys Lys Thr Pro Pro Lys Asp Val Glu 
            580                 585                 590         


Val Met Leu Leu Lys Lys Ile Lys Ser Arg Val Glu Gln Leu Leu Asn 
        595                 600                 605             


Tyr Ser Ser Asp Glu Glu Leu Pro Ser Lys Leu Lys Asn Arg Ile Ala 
    610                 615                 620                 


Asp Ile Glu Gln Tyr Asn Leu Asp Lys Ile Ser Arg His Ile His Asn 
625                 630                 635                 640 


Met Thr Lys Glu Asn Pro Leu Lys Asp Ile Arg Gly Asp Arg Tyr Glu 
                645                 650                 655     


Ser Gly Lys Val Leu Ser Asn Ser Glu Lys Gly Lys Leu Ala Val Trp 
            660                 665                 670         


Leu Ser Glu Asp Ile Lys Arg Met Val Lys Lys Arg Leu Asp Gln Arg 
        675                 680                 685             


Leu Asn His Asn Ser Glu Asn Lys Glu Lys Thr Phe Glu Gly Trp Lys 
    690                 695                 700                 


Gly His Glu Phe Ala Glu Phe Gln Lys Leu Leu Ser Tyr Tyr Asp Phe 
705                 710                 715                 720 


Pro Glu Glu Lys Lys Asn Phe Lys Glu His Cys Ile His Ile Leu Lys 
                725                 730                 735     


Leu Asn Leu Ser Thr Asp Leu Pro Phe Asp Gly Ile Asp Leu Asp Gln 
            740                 745                 750         


Asn Ser Leu Leu Asp Leu Phe Asn Ile Tyr Phe Glu Ala Arg Lys Lys 
        755                 760                 765             


Tyr Leu Tyr Ser Phe Leu Asn Arg Asp Lys Val Lys Val Val Asn Asp 
    770                 775                 780                 


Glu Lys Leu Phe Glu Phe Arg Glu Asn Ser Leu Lys Glu Val Leu Leu 
785                 790                 795                 800 


Ile Leu Asn Glu Asn Lys Phe Lys Lys Lys Ser Leu Glu Arg Phe Lys 
                805                 810                 815     


Lys Asn Leu Gly Lys Asn Pro Ile Cys Leu Asp Arg Gly Ile Phe Gln 
            820                 825                 830         


Asp Leu Pro Thr Phe Thr Lys Arg Thr Asn Glu Lys Thr Val Pro Ile 
        835                 840                 845             


Asn Pro Glu Phe Ala Asp Gly Gly Phe Ala Gln Trp Phe Ile Asp Ser 
    850                 855                 860                 


Ser Asp Arg Met Gln Ala Gln Glu Phe Tyr Ser Tyr Thr Arg Cys Tyr 
865                 870                 875                 880 


Arg Leu Ser Glu Asn Lys Lys Ile Thr Leu Asn Asn Ser Lys Asn Ile 
                885                 890                 895     


Lys Asp Ala Phe Asn Asn Thr Leu Ser Ile Ala Lys Ser Glu Lys Leu 
            900                 905                 910         


Ser Ser Asp Val Phe Thr Lys Arg Asn Val Tyr Gln Thr Glu Ala Ala 
        915                 920                 925             


Ile Arg Lys Arg Met Arg Glu Asp Tyr Phe Met Leu Glu Met Ile Lys 
    930                 935                 940                 


Tyr Phe Tyr Glu Asn Ser Asn Glu Glu Asp Thr Ser Leu Asp Val Leu 
945                 950                 955                 960 


Asn Leu Asn Lys Phe Tyr Leu Thr Lys Thr Glu Ile Glu Glu Val Lys 
                965                 970                 975     


Glu Arg Leu Lys Tyr Glu His Val Arg Ala Pro Gly Asp Asn Ser Asp 
            980                 985                 990         


Ser Val Leu Asn Met Ser Lys Val  Leu Ser Lys Pro Ile  Arg Val Ser 
        995                 1000                 1005             


Phe Leu  Asn Gly Cys Ile Lys  Gly Glu Val Lys Leu  Lys Glu Lys 
    1010                 1015                 1020             


Ser Lys  Tyr Arg Lys Phe Ser  Glu Arg Gln Leu Val  Lys Gln Ile 
    1025                 1030                 1035             


Val Glu  Tyr Tyr Pro Lys His  Pro Leu Thr Ser Glu  Ala Trp Thr 
    1040                 1045                 1050             


Phe Glu  Gln Met Ala Lys Glu  Val His Asn Tyr Asp  Leu Asn Arg 
    1055                 1060                 1065             


Ala Arg  Thr Ile Phe Lys Glu  Ile His Val Leu Glu  Asn Arg Ile 
    1070                 1075                 1080             


Tyr Ser  Ile Ala Glu Arg Lys  Gly Lys Val Asp Glu  Leu Lys Asp 
    1085                 1090                 1095             


His Asn  Gly Asn Leu Asn Phe  Arg Phe Tyr Leu Gln  His Ala Phe 
    1100                 1105                 1110             


Leu Ile  Gly Asn Gln Lys Val  Gln Phe Lys Asn Leu  Tyr Asp Lys 
    1115                 1120                 1125             


Ile Leu  Gln Gly Asn Asn Leu  Met Pro His Glu Leu  Glu Asn Glu 
    1130                 1135                 1140             


Lys Phe  Met Asn Leu Ala Leu  Val Leu Asp Ile Arg  Asn Lys Phe 
    1145                 1150                 1155             


Ser His  Ser Tyr Leu Pro Tyr  Arg Ile Met Phe Asp  Tyr Ala Lys 
    1160                 1165                 1170             


Ser Lys  Val Leu Leu Lys Lys  Glu Glu Ile Glu Gly  Ala Gln Asn 
    1175                 1180                 1185             


Ile Glu  Met Leu Gly Asp Tyr  Phe His Arg Val Leu  Ser Phe Leu 
    1190                 1195                 1200             


Ser Leu  Lys Leu Ile Glu Glu  Leu Glu Phe Glu Lys  Arg Leu Asn 
    1205                 1210                 1215             


Ala 
    


<210>  2628
<211>  1220
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2628

Met Ser Thr Arg Tyr Thr Asn Gln Lys Lys Val Glu Glu Asn Ile Asn 
1               5                   10                  15      


Tyr Val Phe Ser Asn Lys Gly Ile Phe Ala Ala Val Ala Glu Lys Thr 
            20                  25                  30          


Leu Thr Asn Tyr Lys Ser Lys Phe Asn Glu Gly Gln Thr Ile Gln Pro 
        35                  40                  45              


Asn Leu His Tyr Phe Ala Val Gly His Thr Phe Lys Asn Ile Asp Thr 
    50                  55                  60                  


Lys Arg Ile Phe Asp Tyr Gln Leu Ser Glu Asp Glu Met Asp Ile Leu 
65                  70                  75                  80  


Pro Thr Lys Tyr Phe Ser Leu Gln Gln Asn Lys Phe Ser Phe Pro Ile 
                85                  90                  95      


Asp Gly Gln Thr Lys Thr Asp Lys Leu Tyr Leu Leu Leu Asp Asn Ile 
            100                 105                 110         


Arg Asn Ile Asn Ala His Phe Ile His Asp Phe Asn Phe Leu Lys Val 
        115                 120                 125             


Asp Asn Ile Asp Glu Asn Ile Ile Cys Phe Leu Ile Asp Ser Phe Glu 
    130                 135                 140                 


Leu Ala Leu Ile Lys Gly Val Phe Ala Lys Lys Tyr Gly Asn Lys Lys 
145                 150                 155                 160 


His Glu Leu Gly Leu Asp Phe Leu Ser Asn Asp Leu Lys Asp Glu Ile 
                165                 170                 175     


Leu Glu Glu Ile Leu Glu Asn Leu Asp Asp Glu Leu Ile Val Phe Met 
            180                 185                 190         


Lys Glu Ile Phe Tyr Gln Thr Leu Tyr Val Val Asp Lys Lys Glu Trp 
        195                 200                 205             


Arg Asn Lys Glu Leu Asn Gln Glu Lys Lys Asp Phe Leu Asp Ser His 
    210                 215                 220                 


Leu Ser Ser Lys Glu Asp Trp Ile Asn Trp Ile Leu Phe Asn Cys Val 
225                 230                 235                 240 


Glu Glu Asp Ile Asp Trp Phe Leu Asn Asn Tyr Gly Asp Ser Asp Pro 
                245                 250                 255     


His Pro Asp Ser Lys Asn His Lys His Lys Val Leu Thr Ile Glu Lys 
            260                 265                 270         


Gly Lys His Leu Ser Phe Glu Gly Ser Leu Phe Met Met Thr Met Phe 
        275                 280                 285             


Leu Tyr Ala Asn Glu Ala Asn Tyr Leu Ile Pro Lys Leu Lys Gly Tyr 
    290                 295                 300                 


Lys Lys Asn Gly Thr Pro Gln Asp Ala Ser Lys Leu Glu Val Phe Arg 
305                 310                 315                 320 


Phe Phe Ala Lys Lys Phe Lys Ser Gln Asp Val Asp Ser Glu His Lys 
                325                 330                 335     


Gln Tyr Val Lys Phe Arg Asp Met Ile Gln Tyr Val Gly Lys Tyr Pro 
            340                 345                 350         


Thr Val Trp Asn Lys His Ile His Leu Asp Asn Tyr Tyr Val Asn Glu 
        355                 360                 365             


Leu Lys Val Ser Ile Leu Glu Asn Glu Ile Thr Gln Leu Phe Glu Gln 
    370                 375                 380                 


Asp Ile Gln Asn Tyr Phe Glu Thr Lys Tyr Gly Leu Gln Lys Phe Ala 
385                 390                 395                 400 


Lys Ala Lys Gly Asp Met His Tyr Ala Phe Val Glu Val Ala Lys Ser 
                405                 410                 415     


Tyr Leu Gln Lys Lys Thr Ile Ser Tyr Lys Gly Lys Tyr Gln Asp Asp 
            420                 425                 430         


Ser Ile Ala Ile Leu Glu Thr Leu Ala Glu Gln Ile Thr Asn Lys Arg 
        435                 440                 445             


Gln Leu Lys Asn Ile Glu Val Lys Leu Leu Arg Phe Ser Asp Thr Asp 
    450                 455                 460                 


Tyr Gln Ser Leu Ser Ser Ile Glu Lys Thr Lys Lys Gln Arg Leu Asp 
465                 470                 475                 480 


Lys Ser Lys Lys Met Phe Leu Asp Lys Ile Lys Glu Ser Lys Lys Thr 
                485                 490                 495     


Ile Asn Lys Thr Thr Glu Lys Phe Ala Lys Arg Val Glu Asp Asn Leu 
            500                 505                 510         


Leu Tyr Ile Ser Asn Gly Arg Asn Ser Asp Arg Phe Met Val Phe Ala 
        515                 520                 525             


Cys Arg Phe Leu Ala Glu Ile Asn Tyr Phe Gly Lys Asp Ala Gln Phe 
    530                 535                 540                 


Lys Met Tyr Glu Asn Tyr Tyr Ser Glu Glu Glu Gln Asn Ala Leu Lys 
545                 550                 555                 560 


Asp Lys Lys Gln Asn Leu Thr Gln Lys Asp Phe Asp Lys Leu His Tyr 
                565                 570                 575     


His Trp Gly Lys Leu Thr His Phe Glu Thr Phe Glu Asn His Val Lys 
            580                 585                 590         


Lys Tyr Pro Asn Trp Asp Met Pro Phe Val Val Gln Asn Asn Ala Ile 
        595                 600                 605             


Tyr Val Lys Ile Pro Gly Ile Asn Phe Ile Lys Asn Thr Ala Phe Cys 
    610                 615                 620                 


Ile Arg Arg Asn Val Ile Asn Tyr Leu Leu Glu His Ala Leu Gly Glu 
625                 630                 635                 640 


Asn Tyr Lys Asp Gln Gln Gly Arg Glu Trp Leu Phe Asp Tyr Tyr Glu 
                645                 650                 655     


Tyr Lys Thr Glu Ala Thr Asp Asn Ala Lys Arg Ile Leu Thr Glu Ser 
            660                 665                 670         


Lys Pro Ile Glu Ala Ser Ser Lys Thr Gln Leu Lys Lys Leu Leu Pro 
        675                 680                 685             


Lys Lys Leu Leu Pro Lys His Ser Pro Leu Glu Thr Glu Asn Lys Glu 
    690                 695                 700                 


Asn Ile Phe Arg Lys Tyr Leu Glu Gln Ala Glu Glu Ser Glu Lys Leu 
705                 710                 715                 720 


Tyr Glu Asn Gln Lys Asp Lys Ala Lys Ala Glu Lys Lys Leu Asp Leu 
                725                 730                 735     


Phe Val Asn Lys Asn Lys Gly Lys Gln Phe Lys Leu Arg Phe Ile Phe 
            740                 745                 750         


Lys Ala Trp Gln Leu Met Tyr Phe Lys Lys Gln Tyr Gln Ile Glu Lys 
        755                 760                 765             


Glu Arg Tyr Ala Glu Leu Glu Lys Leu Asp Gly Ile Pro Lys Asn Tyr 
    770                 775                 780                 


Glu His Glu Phe Gly His His Lys Lys Phe Asn Ile Asn Arg Lys Glu 
785                 790                 795                 800 


Phe Asn Leu Phe Ser Lys Trp Leu Phe Ala Met Asp Glu Val Pro Glu 
                805                 810                 815     


Tyr Lys Asn Ser Leu Lys Glu Leu Leu Asp Asp Lys Asn Phe Phe Val 
            820                 825                 830         


Asn Ser Glu Phe Gln Lys Leu Phe Glu Ser Ser Ser Asn Ile Asn Gln 
        835                 840                 845             


Phe Tyr Glu Ser Thr Lys Ser Lys Phe Lys Asn Trp Leu Asn Asp Gln 
    850                 855                 860                 


Gln Val Gln Asn Ile Arg Lys Thr Ile Gln Pro Glu Asn Tyr Tyr Lys 
865                 870                 875                 880 


Met Met Glu Val Gly Asn Phe His Ile Asn Leu Ser His Phe Ile Ala 
                885                 890                 895     


Phe Gly Val Ser His Asp Phe Ile Glu Lys Ser Gly Lys Asn Ile Leu 
            900                 905                 910         


Arg Pro Ile Thr Ser His Ala Lys Tyr Leu Asn Thr Lys Ile Tyr Asp 
        915                 920                 925             


Ile Asp Leu Glu His Ser Asp Ala Ser Asn Leu Glu Lys Asn Ile Phe 
    930                 935                 940                 


Arg Lys Leu Tyr Lys Ile Arg Leu Glu Asp Cys Leu Leu Tyr Glu Ile 
945                 950                 955                 960 


Ala Leu Arg Tyr Phe Gln Pro Asn Leu Asn Leu Arg Gln Lys Ser Tyr 
                965                 970                 975     


Glu Gln Leu Asn Lys Leu Leu Val Gln Lys Ile Ser Ile Ala Ile Lys 
            980                 985                 990         


Ala Asn Asn Ser Gln Thr Tyr Gln  Val Leu Val Pro Phe  Lys Asp Leu 
        995                 1000                 1005             


Glu Lys  Phe Ala Gln Leu Lys  Ala Ile Asp Asp Asn  Thr Gln Asn 
    1010                 1015                 1020             


Lys Phe  Ser Leu Leu Arg Arg  Leu Pro Glu Tyr Leu  Ser Gln Val 
    1025                 1030                 1035             


Asn Glu  Arg Asn Glu Asn Val  Ser Gly Leu Lys Asp  Met Val Glu 
    1040                 1045                 1050             


Ala Phe  Gly Val Asp Lys Ser  Ile Ser Leu Ala Asp  Met Ser Met 
    1055                 1060                 1065             


Leu Tyr  Asn His Leu Ile Thr  Gln Gln Gly Arg Tyr  Thr Asn Cys 
    1070                 1075                 1080             


Ile Met  Ala Leu Glu Glu Tyr  Phe Ile Trp Lys Glu  Lys Phe Thr 
    1085                 1090                 1095             


Ile Glu  Lys Gln Glu Ser Lys  Lys Phe Lys Asn Arg  Ile Val Val 
    1100                 1105                 1110             


Thr Glu  Ile Pro Val Leu Lys  Asp Tyr Phe Lys Arg  Asp Glu Gln 
    1115                 1120                 1125             


Arg Asn  Asn Ala Phe His Met  Asp Leu Pro Ile Asn  Glu Thr Tyr 
    1130                 1135                 1140             


Lys Ser  Thr Phe Lys Ala Ile  Glu Lys Gln Phe Val  Ala Thr Glu 
    1145                 1150                 1155             


Val Asp  Lys Ala Tyr Thr Lys  Leu Asp Asp Cys Pro  Ser Met Leu 
    1160                 1165                 1170             


Lys Asn  Thr Leu Lys Val Phe  Met Asn Gln Met His  Asp Glu Ile 
    1175                 1180                 1185             


Lys Leu  Gly Tyr Lys Pro Asn  Asp Thr Lys Asp Gly  Ile Lys Gln 
    1190                 1195                 1200             


Lys Arg  Thr Val Ala Glu Asn  Thr Phe Phe Lys Gln  Leu Leu Lys 
    1205                 1210                 1215             


Gly Tyr  
    1220 


<210>  2629
<211>  1145
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2629

Met Glu Thr Leu Thr Ile Pro Glu Val Ile Lys Cys Arg Thr Leu Ser 
1               5                   10                  15      


Asp Asp Pro Gln Phe Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Val Phe Asn Ile Ser Asn His Ile Ala Lys Glu Phe Asn Leu Ser Leu 
        35                  40                  45              


Leu Ser Glu Glu Ala His Leu Lys Asp Ser Phe Leu Cys Lys Lys Glu 
    50                  55                  60                  


Asn Lys Lys Ile Asn Trp Asn His Val Tyr Ser Gln Thr Lys Arg Phe 
65                  70                  75                  80  


Leu Ser Val Leu Lys Val Phe Asp Ala Ala Cys Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Lys Thr Ile Asn Trp Glu Gly Lys Asp Phe Ala Ser Met Cys Asp 
            100                 105                 110         


Thr Leu Asn Ile Val Phe Gly Glu Leu Gln Glu Phe Ser Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Thr Ile Arg Lys Thr Thr Val 
    130                 135                 140                 


Ser Glu Glu Met Ala Leu Phe Leu Lys Ile Asn Phe Asn Arg Ala Ile 
145                 150                 155                 160 


Glu Tyr Thr Lys Glu Lys Phe Lys Gly Val Leu Asn Asp Glu Asp Tyr 
                165                 170                 175     


Leu Leu Val Ala Ser Ile Glu Leu Phe Gly Ala Glu Asn Arg Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Arg Leu Ile Gly Lys Ile Lys Glu Leu Leu Gly Thr Gln Asn 
    210                 215                 220                 


Asn Cys Phe Ile Ala Ile Arg Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro His Asn Arg Phe Gln Ser Asp Asn Thr Arg Gln Ala Phe Ser 
                245                 250                 255     


Leu Asp Leu Ile Asn Glu Leu Asn Arg Cys Pro Lys Val Leu Tyr Asn 
            260                 265                 270         


Ala Ile Ala Glu Glu Gly Lys Lys Lys Leu Arg Ser Ile Pro Gly Glu 
        275                 280                 285             


Pro Glu Asn Lys Asn Leu His Asp Asn Asn Thr Lys Lys Glu Ala Lys 
    290                 295                 300                 


Ile Glu Ala Glu Ala Tyr Glu Leu Tyr Ile Glu Ser Leu Thr Arg Gln 
305                 310                 315                 320 


Ile Arg Tyr Ser Asn Arg Phe Pro Asp Phe Ala Leu Lys Phe Ile Asp 
                325                 330                 335     


Glu Thr Asp Ile Phe Ser Glu Phe Arg Phe Gln Ile Asp Leu Gly Lys 
            340                 345                 350         


Leu Leu Val Asp Glu Tyr Leu Lys Phe Phe Asn Gly Glu Gln Val Gln 
        355                 360                 365             


Arg Arg Ile Ile Glu Asn Val Lys Ala Phe Gly Lys Ile Asn Asp Phe 
    370                 375                 380                 


Asn Asp Glu Ala Lys Val Met Asn Arg Ile Gly Asn Gly His Ser Leu 
385                 390                 395                 400 


Lys Arg Phe Glu Gln Phe Ala Pro His Tyr Asn Thr Glu Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Arg His Gln Ser Thr Ala Lys Leu Gly Ser Gly Ser 
            420                 425                 430         


Lys Gly Glu Thr Glu Gln Lys Leu His Gln Pro Leu Pro Glu Ala Phe 
        435                 440                 445             


Leu Ser Leu His Glu Leu Pro Lys Val Ile Leu Leu Asp Tyr Leu Gln 
    450                 455                 460                 


Lys Gly Glu Pro Glu Lys Leu Ile Asn Asp Phe Ile Leu Ile Asn Asn 
465                 470                 475                 480 


Ser Lys Leu Met Asn Met Ser Phe Ile Glu Ala Val Lys Thr Gln Leu 
                485                 490                 495     


Pro Pro Glu Trp Asp Glu Phe Gln Arg Arg Thr Asp Ala Lys Lys Glu 
            500                 505                 510         


Met Ala Tyr Asn Glu Lys Thr Leu Ala Tyr Leu Leu Gln Arg Lys Gln 
        515                 520                 525             


Ile Leu Asn Gln Val Leu Thr Ala Tyr Gln Leu Asn Asp Lys Gln Ile 
    530                 535                 540                 


Pro Gly Arg Ile Leu Asp Tyr Trp Leu Asn Val Thr Asp Ala Glu Glu 
545                 550                 555                 560 


Glu Arg Ala Ile Ser Asn Arg Ile Lys Ser Ile Lys Arg Asp Cys Met 
                565                 570                 575     


Ser Arg Leu Lys Ala Leu Gly Lys Phe Asn Glu Asp Arg Asn Arg Asn 
            580                 585                 590         


Lys Ile Pro Gly Ile Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile 
        595                 600                 605             


Val Asp Met Val Val Ser Glu Gly Lys Lys Arg Lys Ile Thr Ser Phe 
    610                 615                 620                 


Tyr Tyr Asn Lys Met Gln Glu Cys Leu Glu Leu Phe Ala Asp Pro Asp 
625                 630                 635                 640 


Lys Lys Gln Leu Phe Ile His Ile Val Thr Lys Glu Leu Lys Leu Asn 
                645                 650                 655     


Asp Ser Gly Gly His Pro Phe Leu Asp Lys Leu Asp Leu Gln Lys Ile 
            660                 665                 670         


Asn Ser Thr Ser Gly Phe Tyr Glu Ile Tyr Leu Gln Glu Lys Gly His 
        675                 680                 685             


Lys Met Val Pro Glu Lys Asn Leu Lys Thr Gly Lys Val Val Asn Thr 
    690                 695                 700                 


Asp Gln Ser Trp Met Ala Leu Thr Phe Tyr Lys Leu Val Phe Asn Asp 
705                 710                 715                 720 


Lys Ala Asp Lys Leu Met Thr Val Val Lys Leu Pro Leu Asn Lys Leu 
                725                 730                 735     


Asn Leu Pro Phe Thr Ile Arg Gln Leu Ser Gly Lys Thr Asn Ser Thr 
            740                 745                 750         


Leu Gly Gln Trp Leu Asn Asn Leu Thr Gln Gly Lys Lys Pro Asp Asp 
        755                 760                 765             


Gly Lys His Pro Val Asn Leu Pro Thr Asn Leu Phe Asp Glu Lys Leu 
    770                 775                 780                 


Ser Asp Leu Leu Arg Gln Asp Leu Asp Asn Lys Lys Ile Ala Tyr Arg 
785                 790                 795                 800 


Pro Tyr Ala Asn Trp Asn Glu Leu Phe Lys Thr Trp Trp Ser Ser Arg 
                805                 810                 815     


Asn Asp Gly Leu Gln Ser Phe Tyr Asn Ala Glu Arg Glu Tyr His Ile 
            820                 825                 830         


Phe Asp Glu Lys Val Asn Phe Tyr Pro Asn Arg Lys Glu Asn Phe Ala 
        835                 840                 845             


Asp Tyr Tyr Gln His Ala Leu Lys Val Ala Phe Gln Lys Lys Arg Ser 
    850                 855                 860                 


Lys Arg Ile Leu Glu Gln Met Tyr Asp Arg His Leu Pro Asp Ile Leu 
865                 870                 875                 880 


Phe Glu Gln Val Glu Lys Thr Phe Lys His Thr Ile Ala Glu Thr Glu 
                885                 890                 895     


Lys Glu Ile Arg Ile Leu Gln Glu Glu Asp Arg Ile Met Leu Leu Met 
            900                 905                 910         


Leu Glu Arg Leu Leu Glu Asp Trp Asn Lys Gln Gln Leu Lys Leu Ser 
        915                 920                 925             


Glu Ile Lys Thr Leu Leu Asn Ala Thr Thr Asn Phe Arg Gln Ser Val 
    930                 935                 940                 


Pro Gly Asn Leu Ser Phe Asp Asn Ser Gly Glu Leu Ile Lys Asp Asn 
945                 950                 955                 960 


Thr Asn Pro Glu Ile Val Lys Thr Ile Thr Val Leu Arg Lys Gln Lys 
                965                 970                 975     


Asp His Ser Ile Met Arg Thr Phe Phe Ala Asp Ser Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Tyr Pro Asp Glu  Glu Ile Gln Met Glu  Ser Leu Lys 
        995                 1000                 1005             


Lys Glu  Phe Asp Thr Tyr Asn  Lys Ala Arg Gln Val  Val Phe Asp 
    1010                 1015                 1020             


Leu Ser  Phe Lys Leu Glu Lys  Met Ile Ile Glu Lys  Gly Arg Lys 
    1025                 1030                 1035             


Asp Arg  Ile Asn Gln Leu Cys  Ala Gly Ala Thr Gly  Glu Leu Leu 
    1040                 1045                 1050             


Thr Gly  His Ile Arg His Lys  Thr Tyr Leu Thr Trp  Leu Lys Asn 
    1055                 1060                 1065             


Lys Gly  Met Ile Asp Asn Asp  Thr Phe Ile Phe Met  Asn Met Val 
    1070                 1075                 1080             


His His  Cys Phe Ser His Asn  Gln Tyr Pro Gln Lys  Asn Thr Met 
    1085                 1090                 1095             


Glu Arg  Ile Ile Ser His Trp  Glu Pro Asp His Phe  Ala Leu Thr 
    1100                 1105                 1110             


Ile Ala  Ala Thr Tyr Asn Gln  Lys Ile Ala Gly Ile  Leu Glu Asp 
    1115                 1120                 1125             


Ile Gly  Thr Phe Pro Phe Ile  Arg Ser Arg Lys Thr  Met Pro Asp 
    1130                 1135                 1140             


Ile Val  
    1145 


<210>  2630
<211>  1126
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2630

Met Glu Thr Leu Thr Ile Pro Glu Val Ile Lys Cys Arg Thr Leu Ser 
1               5                   10                  15      


Asp Asp Pro Gln Phe Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Val Phe Asn Ile Ser Asn His Ile Ala Lys Glu Phe Asp Leu Pro Leu 
        35                  40                  45              


Leu Ala Glu Glu Asp His Leu Arg Asn Ser Phe Leu Cys Asn Lys Glu 
    50                  55                  60                  


Asn Lys Lys Ile Asn Trp Asn His Leu Tyr Ser Arg Thr Asn Arg Phe 
65                  70                  75                  80  


Leu Ser Val Leu Lys Val Phe Asp Ala Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Lys Thr Thr Asn Leu Glu Gly Lys Asp Phe Ala Leu Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Ile Val Phe Gly Glu Leu Gln Asp Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Thr Ile Arg Lys Thr Thr Val 
    130                 135                 140                 


Ser Asp Glu Met Ala Leu Phe Leu Lys Val Asn Phe Asn Arg Ala Ile 
145                 150                 155                 160 


Glu Tyr Thr Lys Glu Arg Phe Lys Gly Val Leu Asn Glu Glu Asp Phe 
                165                 170                 175     


Gln Leu Val Ala Ser Lys Lys Val Met Glu Ala Asn Leu Thr Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Cys Leu Ile Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Thr Gly Leu Lys Gly Thr Glu Asn 
    210                 215                 220                 


Lys Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro His Asp Arg Phe Gln Ser Asp Asn Thr Arg Gln Ala Phe Ser 
                245                 250                 255     


Leu Asp Leu Ile Asn Glu Leu Asn Arg Cys Pro Lys Val Leu Tyr Asn 
            260                 265                 270         


Ser Ile Thr Ala Ser Gly Lys Gln Ile Phe Gln Pro Lys Leu Asp Ile 
        275                 280                 285             


Leu Gly Ile Lys Asn Leu Leu Asp Asn Ser Thr Asn Ile Asp Glu Glu 
    290                 295                 300                 


Val Glu Asp Tyr Asp Glu Tyr Ile Glu Ala Leu Thr Lys Arg Ile Arg 
305                 310                 315                 320 


His Ser Asn Arg Phe Ser Asp Phe Ala Leu Lys Tyr Ile Asp Glu Thr 
                325                 330                 335     


Gly Ile Phe Asp Lys Phe Arg Phe Gln Ile Asp Leu Gly Lys Leu Leu 
            340                 345                 350         


Val Asp Glu Tyr Ala Lys Phe Phe Asn Ser Glu Glu Val Pro Arg Arg 
        355                 360                 365             


Ile Ile Glu Asn Val Lys Ala Phe Gly Lys Leu Asn Ser Phe Asn Asp 
    370                 375                 380                 


Glu Ala Lys Val Leu Thr Arg Ile Gly Asn Gly Tyr Pro Ser Lys Glu 
385                 390                 395                 400 


Phe Glu Gln Phe Ser Pro His Tyr Asn Thr Glu Asn Asn Lys Ile Gly 
                405                 410                 415     


Ile Ser Val Lys Glu Asp Thr Ala Lys Leu Arg Pro Asn Ser Lys Gly 
            420                 425                 430         


Glu Thr Gly Lys Lys Leu His Gln Pro Leu Pro Glu Ala Phe Leu Ser 
        435                 440                 445             


Leu His Glu Leu Pro Lys Val Ile Ile Leu Asp Tyr Leu Gln Lys Gly 
    450                 455                 460                 


Glu Pro Glu Arg Leu Ile Glu Asp Phe Ile Leu Ile Asn Asn Ser Lys 
465                 470                 475                 480 


Leu Met Thr Met Pro Phe Ile Glu Ala Val Lys Ser Gln Met Pro Lys 
                485                 490                 495     


Glu Trp Asp Asp Phe Arg Arg Arg Thr Asp Thr Lys Lys Glu Met Ala 
            500                 505                 510         


Tyr Asn Glu Lys Thr Leu Thr Tyr Leu Leu Glu Arg Lys Asn Thr Leu 
        515                 520                 525             


Asn Gln Val Leu Ala Glu Tyr Gln Leu Asn Asp Lys Gln Ile Pro Gly 
    530                 535                 540                 


Arg Ile Leu Asp Tyr Trp Leu Asn Ile Lys Asp Val Glu Glu Gly Arg 
545                 550                 555                 560 


Ala Val Ser Asp Arg Ile Lys Ser Ile Lys Arg Asp Cys Met Ser Arg 
                565                 570                 575     


Leu Arg Ala Leu Glu Lys Phe Lys Ile Asp Arg Asn Arg Asn Lys Ile 
            580                 585                 590         


Pro Lys Ile Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile Val Asp 
        595                 600                 605             


Met Val Ala Gly Glu Glu Lys Lys Gln Lys Ile Thr Ser Phe Tyr Tyr 
    610                 615                 620                 


Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Ser Asp Lys Lys 
625                 630                 635                 640 


Gln Leu Phe Ile His Thr Val Cys Asn Glu Leu Arg Leu Asn Glu Thr 
                645                 650                 655     


Gly Gly His Pro Phe Leu Tyr Lys Leu Asp Leu Gln His Ile Asn Ser 
            660                 665                 670         


Thr Ser Glu Phe Tyr Gly Lys Tyr Leu Gln Glu Lys Gly His Lys Met 
        675                 680                 685             


Val Arg Glu Lys Asn Leu Arg Thr Gly Arg Val Ala Glu Val Asp Gln 
    690                 695                 700                 


Ser Trp Met Ala Thr Thr Phe Tyr Lys Lys Glu Trp Asn Glu Lys Ile 
705                 710                 715                 720 


Gly Lys Gln Leu Thr Val Val Lys Leu Pro Leu Asn Lys Ser Lys Ile 
                725                 730                 735     


Pro Phe Thr Leu Arg Leu Leu Glu Glu Lys Thr Ile Tyr Thr Leu Asp 
            740                 745                 750         


Gln Trp Leu Gln Asn Leu Thr Lys Gly Arg Asn Pro Asn Asp Ala Lys 
        755                 760                 765             


His Pro Val Asn Leu Pro Thr Asn Leu Phe Asp Glu Arg Leu Thr Val 
    770                 775                 780                 


Leu Leu Arg His Asp Leu Asp Glu Arg Gln Ile Ser Tyr Pro Ser Asn 
785                 790                 795                 800 


Ser Tyr Asp Asn Glu Leu Phe Lys Ile Trp Trp Lys Ser Arg Ser Asp 
                805                 810                 815     


Ser Thr Gln Ser Phe Tyr Asn Ala Glu Arg Glu Tyr Val Ile Phe Gly 
            820                 825                 830         


Glu Lys Val Asn Phe Met Pro Asn Thr Lys Asp Asn Phe Ala Asp Tyr 
        835                 840                 845             


Tyr Gln His Ala Phe Thr Thr Ala Tyr Gln Lys Lys Arg Lys Glu Arg 
    850                 855                 860                 


Thr Leu Gln Gln Lys Glu Asp Arg Arg Leu Pro Asn Ile Gln Leu Glu 
865                 870                 875                 880 


Gln Val Glu Lys Thr Phe Lys Gln Thr Ile Ala Gly Thr Glu Lys Glu 
                885                 890                 895     


Ile Arg Met Leu Gln Glu Glu Asp Arg Ile Met Leu Leu Met Ile Glu 
            900                 905                 910         


Ser Leu Leu Glu Asp Gly Lys Lys Met Gln Leu Lys Leu Ser Glu Ile 
        915                 920                 925             


Asp Thr Leu Leu Asn Ala Ala Thr Glu Val Lys Gln Thr Val Ser Ala 
    930                 935                 940                 


Lys Leu Ser Phe Asn Asp Ser Gly Glu Leu Ile Lys Asp Lys Thr Asn 
945                 950                 955                 960 


Pro Ala Ile Val Arg Thr Ile Thr Val Ser Arg Lys Arg Lys Asp Tyr 
                965                 970                 975     


Ser Met Leu Arg Lys Phe Ile Phe Asp Arg Arg Leu Pro Glu Leu Phe 
            980                 985                 990         


Glu Tyr Phe Pro Glu Lys Glu Ile  Gln Leu Asp Ser Leu  Lys Glu Glu 
        995                 1000                 1005             


Leu Asp  Ala Tyr Asn Lys Ala  Lys His Glu Val Phe  Asp Val Val 
    1010                 1015                 1020             


Phe Glu  Leu Glu Ala Lys Ile  Ile Ala Lys Asp Ser  Asp Gly Ile 
    1025                 1030                 1035             


Gln Gln  Leu Phe Ala Asp Glu  Ser Gly Lys Pro Leu  Thr Gly Asn 
    1040                 1045                 1050             


Ile Gln  His Lys Pro Tyr Leu  Thr Trp Leu Lys Asn  Lys Gly Leu 
    1055                 1060                 1065             


Leu Asp  Asp Asn Thr Phe Thr  Phe Leu Asn Met Val  Arg Asn Cys 
    1070                 1075                 1080             


Phe Ser  His Asn Gln Tyr Pro  Gln Lys Lys Thr Met  Glu Arg Leu 
    1085                 1090                 1095             


Ile His  His Trp Glu Pro Asn  Arg Phe Ala Leu Thr  Ile Ala Ser 
    1100                 1105                 1110             


Lys Tyr  Lys Gln Glu Ile Ala  Arg Ile Met Glu Asp  Leu 
    1115                 1120                 1125     


<210>  2631
<211>  1145
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2631

Met Thr Leu Pro Thr Asp Asn Thr Phe Ile Glu Lys Ala Asp Gln Glu 
1               5                   10                  15      


Ile Leu Gly Lys Asn Lys Leu Phe Phe Gly Ala Tyr Leu Asn Met Ala 
            20                  25                  30          


Asn His Asn Ala Tyr Leu Ile Ile Lys Asp Ile Ser Glu Arg Leu Lys 
        35                  40                  45              


Gln Glu Asp Ala Leu Asp Ile Asp Ala Pro Ser Asp Glu Asp Asn Leu 
    50                  55                  60                  


Ala Tyr Ala Asp Ile Phe Ser Lys Ile Leu Lys Lys Ala Ser Asp Lys 
65                  70                  75                  80  


Asn Pro Lys Asn Arg Pro Gln Ala Thr Ile Ile Asp Lys Val Thr Asn 
                85                  90                  95      


Leu Leu Ile His His Phe Pro Ala Phe Glu Val Phe Ala Tyr Glu His 
            100                 105                 110         


Pro Phe Glu Gln Gln Asn Ser Tyr Pro Glu Leu Leu Tyr Gln Lys Leu 
        115                 120                 125             


Thr Thr Ala Leu Lys Leu Leu Asn Asp Leu Arg Asn Glu His Ser His 
    130                 135                 140                 


Phe Tyr Tyr Lys Gly Ser Phe Asp Ile Asp Thr Val Phe Ser Ala Ala 
145                 150                 155                 160 


Gln Glu Glu Ile Thr Arg Phe Pro Tyr Leu Thr Pro Glu Asp Ile Glu 
                165                 170                 175     


Glu Leu Glu Tyr Tyr Lys Asn Asp Leu Leu Glu Pro Leu Thr Tyr Phe 
            180                 185                 190         


Lys Lys Tyr Gly Phe Val Phe Phe Ile Cys Thr Phe Leu Glu Lys Arg 
        195                 200                 205             


Tyr Ala Arg Tyr Met Leu Lys Glu Lys Gln Leu Asp Leu Ile Ala Ser 
    210                 215                 220                 


Asp Lys Glu Arg Asp Ala Thr Leu Glu Asn Phe Thr Asn Tyr Ser Cys 
225                 230                 235                 240 


Arg Leu Pro Arg Pro Lys Leu Glu Ser Ser Val Ile Glu Leu Asp Met 
                245                 250                 255     


Leu Asn Glu Leu Ser Arg Cys Pro Lys Gly Ile His Asp Val Leu Ser 
            260                 265                 270         


Ser Pro Met Glu Lys Val Leu Leu Lys Thr Asp Ala Lys Asp Asp Pro 
        275                 280                 285             


Asn Gln Val Pro Met Ile Arg His Asn Asp Arg Phe Pro Tyr Phe Ala 
    290                 295                 300                 


Leu Ser Tyr Phe Asp Lys Met Glu Arg Phe Pro Ala Met Arg Phe His 
305                 310                 315                 320 


Ile Trp Ala Gly Lys Thr Arg Leu Ala Phe Tyr Gly Lys Lys Leu Gly 
                325                 330                 335     


Lys Lys Asn Val Leu Arg Asp Ile Gln Glu Asn Val Thr Ile Tyr Ala 
            340                 345                 350         


Arg Leu Asn Asp Ile Lys Ala Asp Lys Ile Pro Asp Asn Trp Lys Asp 
        355                 360                 365             


Lys Ile Asp Val Glu Asp Ser Glu Glu Asn Lys Glu Lys Ala Lys Ile 
    370                 375                 380                 


Gln Ser Tyr Ser Pro His Tyr Asn Ile His Asn Asn Arg Ile Ala Ile 
385                 390                 395                 400 


Lys Phe Ile Asp Thr Gln Lys Asp Glu Leu Asp Thr Glu Asn Phe Ser 
                405                 410                 415     


Glu Ile Lys Ser Lys Pro Gln Asp Pro Thr Lys Asp Lys Gln Leu Lys 
            420                 425                 430         


Tyr Thr Val Thr His Ala Leu Pro Asn Ala Ile Leu Ser Thr Tyr Glu 
        435                 440                 445             


Leu Gln Asn Leu Phe Leu Tyr Asp Tyr Leu Tyr Arg Thr Tyr Lys Asp 
    450                 455                 460                 


Gln Lys Val Leu Ala Arg Pro Ala Asp Ser Phe Ile Arg Asn Tyr Ile 
465                 470                 475                 480 


Ser Ser Phe His Arg Phe Cys Lys Asp Val Lys Ser Gly Lys Ile Gln 
                485                 490                 495     


Pro Val Ser Pro His Asp Phe Glu Arg Leu Thr Glu His Thr Arg Ser 
            500                 505                 510         


Thr Thr Arg Asp Leu Gly Asn Arg Glu Glu Glu Leu Glu Ile Arg Lys 
        515                 520                 525             


Glu Ala Leu Gln Lys Lys Lys Leu Asp Asn Tyr Gly Leu Lys Val Lys 
    530                 535                 540                 


Asn Leu Pro Asp Ala Leu Arg Glu Tyr Leu Leu Gly Tyr Lys Gln Glu 
545                 550                 555                 560 


Thr Tyr Thr Glu Ile Ala Leu Asn Lys Leu Arg Gly Lys Ile Lys Gln 
                565                 570                 575     


Thr Lys Val His Tyr Lys Leu Ala Thr Lys Asp Asp Leu Phe Leu Asp 
            580                 585                 590         


Gly Lys Thr Asp Leu Lys Ser Gly Lys Ile Gly Asp Phe Leu Ala Ala 
        595                 600                 605             


Asp Ile Val Phe Leu Lys Pro Leu Asp Ala Asn Arg Thr Gly Lys Pro 
    610                 615                 620                 


Asn Asn Gln Gln Phe Asn Glu Leu Gln Lys Ala Ile Ala Arg Phe His 
625                 630                 635                 640 


Ser Gln Lys Lys Asp Val Glu Asp Phe Ile Asn Glu Glu Leu Gln Ile 
                645                 650                 655     


Lys Glu Gln Ser Leu Pro His Ala His Pro Phe Leu Tyr Lys Ile Gln 
            660                 665                 670         


Phe Glu Glu His Thr Asp Val Gln Ser Phe Tyr Ile Lys Tyr Leu Glu 
        675                 680                 685             


Leu Lys Ile Glu Trp Leu Glu Cys Thr Lys Arg Glu Ile Gln Gly Lys 
    690                 695                 700                 


Ser Asp Tyr Leu Lys Pro Trp Gln Trp Arg Glu Glu Ala Asp Lys Cys 
705                 710                 715                 720 


Lys Gln Tyr Gly Ile Asp Ile Lys Pro Glu Gly Leu Ser Asp Ala Ala 
                725                 730                 735     


Thr Glu Asn Lys Tyr Gly Tyr Phe Leu Gln Ile Asn Thr Lys Lys Gly 
            740                 745                 750         


Asn Glu Arg Asn Tyr Thr Asn Ala Thr Thr Pro Ser Lys Ala Asn Ser 
        755                 760                 765             


Lys Glu Phe Glu Ser Leu Glu Ser Lys Ser Pro Val Ile Leu Pro Arg 
    770                 775                 780                 


Gly Leu Phe Asn Asp Ala Ile Ile Asp Ala Met Met Lys Ile Asp Glu 
785                 790                 795                 800 


Phe Lys Gly Lys Ile Lys Glu Gly Asp Asn Ile Val Arg Cys Leu Asp 
                805                 810                 815     


Val Leu Ala Glu Gly Asp Arg Gln Thr Phe Tyr Asp Phe Glu Arg Ser 
            820                 825                 830         


Tyr Thr Val Gly Lys Ala Ala Pro Thr Ser Val Thr Ile His Gln Gly 
        835                 840                 845             


Ala Asn Asp Glu Tyr Ile Lys Asn Lys Leu Arg Ser Ile Lys Pro Ile 
    850                 855                 860                 


Ile Lys Lys Leu Arg Thr Gln Gln Asn Ala Lys Asp Ala Lys Tyr Lys 
865                 870                 875                 880 


Asp Lys Lys Ile Leu Gln Asn His Ile Lys Ala Leu Gln Ala Ile Ser 
                885                 890                 895     


Asp Asn Glu Arg Ser Ile Arg Phe Ile Arg Ala Asn Asp Arg Ala Leu 
            900                 905                 910         


Phe Leu Met Ile Lys His Ile Phe Ser Glu His Lys Ser Tyr Val Val 
        915                 920                 925             


Glu Gly Ser Lys Leu Thr Lys Ser Ile Asn Thr Leu Pro Trp Lys Leu 
    930                 935                 940                 


Asn Lys Val Gly Tyr Glu Ile Lys Glu Asn Asn Ile Leu Asn Glu Ile 
945                 950                 955                 960 


Leu Pro Met Asn Ile Gln Phe Asn Gln Lys Asn Ile Tyr Thr Glu Gly 
                965                 970                 975     


Glu Tyr Gly Thr Asp Pro Leu Asn Lys Leu Ser Ile Lys His Tyr Gly 
            980                 985                 990         


Lys Phe Arg Lys Leu Leu Lys Asp  Lys Arg Leu Ser Asn  Lys Lys Lys 
        995                 1000                 1005             


Pro Gly  Leu Leu Asn Tyr Tyr  Thr Asp Gln Asn Val  Arg Trp Ser 
    1010                 1015                 1020             


Ala Ile  Asn Lys Glu Leu Glu  Tyr Tyr Asp Glu Asn  Arg Asp Arg 
    1025                 1030                 1035             


Leu Leu  Asp Glu Ile Tyr Lys  Phe Glu Lys Ala Val  Trp Glu Asn 
    1040                 1045                 1050             


Glu Glu  Cys Arg Glu Glu Leu  Lys Glu Asn Ile Arg  Leu Gly Tyr 
    1055                 1060                 1065             


Ile Asn  His Ala Ala Gln Leu  Lys Ala Val Gly Lys  Ile Val Arg 
    1070                 1075                 1080             


Asp Phe  Thr Ala Ser Lys Gln  Asp Gln Leu Ala Leu  Leu Arg Asn 
    1085                 1090                 1095             


Lys Phe  Leu His Asn Gln Ile  Pro Tyr Thr Glu Asn  Leu Lys Thr 
    1100                 1105                 1110             


Gly Trp  Val Asp Asn Asn Pro  Glu Tyr Pro Leu Ile  Thr Gln Ala 
    1115                 1120                 1125             


Leu Leu  Glu Leu Ala Ile Ile  Glu Tyr Gln Asn Ile  Thr Lys Asn 
    1130                 1135                 1140             


Ile Ile  
    1145 


<210>  2632
<211>  974
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2632

Met Ser Ile Pro Lys Leu Arg Arg Pro Asp Arg Tyr Leu Thr Asn Leu 
1               5                   10                  15      


Ser Leu Gly Phe Asn Trp Ala Leu Asp Asn Leu Gln Lys Ile Asp Pro 
            20                  25                  30          


Glu Phe Ser Pro Gly Ser Pro Val Pro Glu Glu Arg Arg Gln Ala Ile 
        35                  40                  45              


Ile Glu Phe Ile Met Gly Arg Lys Val Pro Tyr Lys Leu Asp Thr Asp 
    50                  55                  60                  


Pro Lys Glu Asn Lys Glu Leu Val Glu Glu Met Phe Thr Thr Lys Lys 
65                  70                  75                  80  


Asp Gly Ser Thr Leu Tyr Ser Gln Leu Arg Asn Leu Leu Arg Glu Tyr 
                85                  90                  95      


Arg Asn Tyr His Cys His Val Cys His Lys Asp Glu Asn Leu Asn Asn 
            100                 105                 110         


Pro Ala Pro Gly Ala Ile Ala Trp Val Glu Lys Arg Phe Asn Glu Ala 
        115                 120                 125             


Lys Glu His Ala Tyr Lys Lys Ile Glu Glu Tyr Arg Leu Ala Thr Ile 
    130                 135                 140                 


Val Asn Glu Asp Gly Lys Thr Asn Pro Asp Ser Ala Ser Glu Leu Asn 
145                 150                 155                 160 


Ala Ile Ile Asp Ala Thr His Arg Lys Met Asp Glu Ile Thr Leu Phe 
                165                 170                 175     


Asp Ala Lys Asn Lys Arg Arg Phe Ser Ser Arg Tyr Gly Val Ile Phe 
            180                 185                 190         


Phe Met Asn Ile Phe Leu Tyr Lys Trp Gln Ala Asn Phe Ile Leu Ser 
        195                 200                 205             


Gln Leu Arg Gly Phe Lys Ala Thr Asn Ile Thr Glu Tyr Asp Gly Ile 
    210                 215                 220                 


Asp Lys Gly Arg Pro Thr Lys Phe Tyr Gly Lys Pro Arg Arg Glu Phe 
225                 230                 235                 240 


Phe Thr Phe Phe Ser Leu Arg Asp Gly Phe Gln Leu Phe Ser Glu Ala 
                245                 250                 255     


Gly Asn Tyr Val Lys Phe Arg Gln Ile Val Asn Leu Leu Tyr Thr Lys 
            260                 265                 270         


Pro Ile Glu Tyr Glu Arg Ile Val Asn Pro Thr Tyr Tyr Glu Lys Lys 
        275                 280                 285             


Ile Leu Ser Arg Asp Lys Lys Ser Lys Glu Gln Tyr Asp Gln Leu Asn 
    290                 295                 300                 


Lys Thr Lys Gln Gln Lys Glu Lys Asn Thr Ile Arg Arg Asn Thr Glu 
305                 310                 315                 320 


Lys Ile Phe Ile Glu Trp Ala Cys Arg Ser Ile Glu Asp Ser Phe Thr 
                325                 330                 335     


Ala Asn Lys Arg Ser Glu Glu Asn Phe Thr Leu Ala Phe Arg Val Tyr 
            340                 345                 350         


Glu Lys Gly Glu Ala His Ser Arg Gln Arg Lys His Asp Gly Val Thr 
        355                 360                 365             


Ala Arg Glu Tyr Val Glu Lys Ile Lys Ser Arg Val Phe Ala Pro Gly 
    370                 375                 380                 


Ala Leu His Asp Tyr Lys Tyr Val Ile Thr His Lys Asn Val Phe Phe 
385                 390                 395                 400 


Arg Ile Thr Tyr Pro Asn Gly Val His Ala Tyr Tyr Gln Ile Gly Val 
                405                 410                 415     


His Glu Leu Lys Phe Trp Val Leu Ala Leu Leu Ala Gly Lys Asn Phe 
            420                 425                 430         


Gln Gly Ile Leu Lys Lys Ile Val Ala Glu Ala Asp Thr Gly Gln Lys 
        435                 440                 445             


Lys Glu Lys Ser Lys Thr Asp Ala Arg Gln Lys Leu Ile Asn Arg Leu 
    450                 455                 460                 


Gln Tyr Val Lys Asn Ile Thr Gly Arg Leu Val Glu Glu Asn Asn Arg 
465                 470                 475                 480 


Tyr Pro Ala Val Lys Arg Trp Arg Phe Ala Ser Lys Arg Lys Ile Ser 
                485                 490                 495     


Leu Ile Met Leu Tyr Val Asn Arg Phe Leu Leu Gln Gly Lys Tyr Leu 
            500                 505                 510         


Asn Arg Tyr Gln Tyr Lys Leu Val Glu Glu Leu Val Arg Trp His Tyr 
        515                 520                 525             


Ala Thr Asn Lys Pro Arg Ile Leu Ser Ile Met Lys Glu Thr Gly Ser 
    530                 535                 540                 


Gln Asp Ala Tyr Arg Leu Phe Ala Asn Ala Asn Ser Ile Glu Glu Leu 
545                 550                 555                 560 


Phe Val Glu Ser Ala Asp Lys Leu Ser Met Arg Val His Arg Ala Leu 
                565                 570                 575     


Glu Met Leu Arg Thr Asn Ser Val Asp Asp Ala Thr Tyr Ala Thr Leu 
            580                 585                 590         


Glu Thr Leu Leu Pro Phe Asn Gly Lys Leu His Arg Gln Glu Pro Lys 
        595                 600                 605             


Asn Val Gly Pro Asp Asn Arg Ile His Tyr Ile Lys Ile Asn Ser Gly 
    610                 615                 620                 


Phe Phe Lys Arg His Leu Phe Gly Ile Ser Ser Ala Lys Tyr Asn Leu 
625                 630                 635                 640 


Ser Ala Val Ile Arg Lys Met Glu Phe Glu Ser Leu Val Tyr Ser Ser 
                645                 650                 655     


Gly Thr Pro Ile Ile Lys Asp Glu Tyr Ala Arg Val Glu Leu Arg Asn 
            660                 665                 670         


Phe Tyr Ser Gly Ala Val Pro Asp Asp Met Lys Phe Gln Lys Val Asp 
        675                 680                 685             


Ala Ala Leu Gln Thr Ala Ser Gln Lys Glu Glu Asn Lys Arg Lys Tyr 
    690                 695                 700                 


Lys Ala Leu Lys Pro Leu Leu Asn Val Glu Thr Leu Asp Arg Leu Leu 
705                 710                 715                 720 


Trp Met Ile Ala Leu Phe Tyr Tyr Arg Lys Glu Phe Gln Val Glu Lys 
                725                 730                 735     


Ile Pro Lys Thr Ala Thr Ile Glu Thr Ile Gln Asp Glu Lys Val Val 
            740                 745                 750         


Met Pro Phe Ser His Ser Leu Glu Val Lys His Gly Gly Pro Ser Val 
        755                 760                 765             


Leu Asp Ala Ile Gln Asn Ser Ile Gln Glu Ile Pro Gly Lys Val Arg 
    770                 775                 780                 


Val Ser Arg Ile Lys Lys Ala Glu Asp Lys Glu Ser Leu Ile Ile Thr 
785                 790                 795                 800 


Leu Ser Asn Ile Ser Leu Gln Ile Pro Pro Tyr Met Leu Lys Arg Asn 
                805                 810                 815     


Leu Val Tyr Ala Asn Glu Asp Asn Leu Ala Ala Ala Leu Leu Met Cys 
            820                 825                 830         


Pro Glu Ile Asn Val Ala Gly Thr Val Asp Tyr Glu Val Val Asn Lys 
        835                 840                 845             


Phe Ile Glu Lys Thr Met Ala Ile Asn Lys Gly Glu Glu Phe Ala Ala 
    850                 855                 860                 


Ser Asp Ile Arg Gln Leu Leu Phe Ala Leu Glu Arg Lys Val Leu Lys 
865                 870                 875                 880 


Lys Asn Glu Leu Lys Val Asn Glu Ile Leu Gly Ser Gln Pro Tyr Val 
                885                 890                 895     


Ser Phe Arg Glu Val Ser Glu Met Ile Lys Arg Glu Phe Val Gln Arg 
            900                 905                 910         


Lys Phe Gln Gln Gln Ile Ser Leu Pro Glu Leu Glu Gln Leu Leu Tyr 
        915                 920                 925             


Leu Arg Asn Cys Ala Met His Asn Lys Ile Pro Leu Gly Phe Arg Phe 
    930                 935                 940                 


Ala Tyr Ala Gly Glu Val Leu Lys Lys Leu Gly Ile Thr Lys Lys Gly 
945                 950                 955                 960 


Ser Glu Arg Glu Asp Trp Arg Gly Arg Gly Arg Arg Met Arg 
                965                 970                 


<210>  2633
<211>  1081
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2633

Met Gln Ala Gln Ser Leu Phe Asp Glu Tyr Lys His Leu Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Val Met Ser Ile Met Asn Ile Ile Thr Val Leu Asn His Ile 
            20                  25                  30          


His Gln Ile Ala Gly Leu Lys Arg Asn Glu Leu Gly Asp Asp Asp Asn 
        35                  40                  45              


Ile Tyr Ser His Pro Val Leu Lys Tyr Ile Ala Pro Glu Asn Asn Ser 
    50                  55                  60                  


Thr Thr Leu Pro Glu Lys Arg Asp Leu Ile Lys Glu Leu Leu Leu Glu 
65                  70                  75                  80  


Tyr Leu Pro Phe Leu Glu Ala Met Lys Asp Cys Tyr Lys Glu Val Lys 
                85                  90                  95      


Val Glu Lys Asp Lys Arg Asn Asn Lys Tyr Val Lys Asp Lys Lys Gln 
            100                 105                 110         


Val Phe Ile Arg Asn Tyr Ser Asp Ile Tyr Cys Ile Tyr Trp Thr Leu 
        115                 120                 125             


Tyr Asn Ile Phe Ser Thr Leu Ile Asn Tyr Arg Asp Lys Ser Cys His 
    130                 135                 140                 


Tyr Arg Phe Ile Pro Ser Lys Asp Gln Glu Glu Tyr Ser Lys Arg Thr 
145                 150                 155                 160 


Glu Tyr Asp Thr Val Arg Ile Ile Asn Lys Tyr Tyr Thr Tyr Ala Leu 
                165                 170                 175     


Arg Lys Thr Lys Glu Lys Tyr Gly Tyr Thr Thr Glu Gln Leu Ser Phe 
            180                 185                 190         


Ile Gln Asn Asn Arg Tyr Thr Asp Asp Lys Lys Val Asn Phe Asn Phe 
        195                 200                 205             


Phe Leu Ser Met Gln Ser Ser Asn Asn Asn Leu Ser His Val Gly Val 
    210                 215                 220                 


Ala Gln Leu Ile Cys Leu Phe Leu Gln Lys Lys Asp Val Asp Asn Phe 
225                 230                 235                 240 


Leu Glu Asn Leu Pro Ile Tyr Asp Asn Arg Tyr Cys Leu Gly Ile Asp 
                245                 250                 255     


Glu His Met Ile Ile Lys Arg Ser Leu Ala Leu His Ser Ile Lys Leu 
            260                 265                 270         


Pro Lys Glu Arg Leu Asn Ser Glu Lys Lys Asp Met Ala Ile Ala Met 
        275                 280                 285             


Asp Met Leu Asn Glu Leu Lys Arg Cys Pro Lys Glu Leu Phe Asn Thr 
    290                 295                 300                 


Leu Pro Phe Asp Lys Gln Glu Arg Phe Arg Ile Ile Ser Ser Asp His 
305                 310                 315                 320 


Lys Glu Val Leu Leu Met Arg Ser Thr Asp Arg Phe Val Pro Leu Ile 
                325                 330                 335     


Leu Gln Tyr Ile Asp Cys Asn Lys Lys Phe Lys Asp Ile Arg Phe His 
            340                 345                 350         


Val Asn Met Gly Lys Leu Arg Tyr Leu Phe Ser Pro Asn Lys Leu Cys 
        355                 360                 365             


Ile Asp Asn Gln Glu Arg Val Arg Met Leu Glu His Leu Leu Asn Gly 
    370                 375                 380                 


Tyr Gly Arg Ile Asp Glu Val Glu Tyr Leu Arg Lys Ala Pro Asn Gly 
385                 390                 395                 400 


Thr Phe Gly Asn Thr Asn Ile Pro Ile Lys Gly Phe Gly Glu Ile Glu 
                405                 410                 415     


Arg Asp Ser Ala Asp Ser Asn Asn Tyr Pro Tyr Ile Val Asp Thr His 
            420                 425                 430         


Thr His Tyr Ile Leu Asn Asn Asn Lys Val Glu Phe Cys Phe Cys Glu 
        435                 440                 445             


Asp Ser Lys Asn Lys Asn Val Phe Pro Thr Ile Glu Lys Glu Ile Asn 
    450                 455                 460                 


Gly Lys Trp Tyr Val Glu Lys Thr Ala Pro His Cys Arg Ile Ser Phe 
465                 470                 475                 480 


Phe Glu Ile Pro Ala Met Ala Phe His Met Phe Leu Cys Gly Ser Glu 
                485                 490                 495     


Lys Thr Glu Lys Leu Ile Lys Asp Val Tyr Asn Asn Tyr Ile Ser Leu 
            500                 505                 510         


Phe Asn Ala Leu Lys Asn Gly Ala Leu Thr Glu Glu Asn Tyr Lys Asp 
        515                 520                 525             


Phe Asn Ile Pro Glu Cys Asp Met Pro Lys Lys Ile Leu Asp Phe Leu 
    530                 535                 540                 


Lys Gly Lys Ala Glu Gly Lys Ser Ile Asp Gly Tyr Val Lys Asn Ile 
545                 550                 555                 560 


Leu Lys Lys Glu Leu Lys Asp Thr Arg Lys Arg Ile Glu Gln Ala Pro 
                565                 570                 575     


Ser Glu Lys Asp Gln Met Pro Ser Lys Arg Asn Lys Ile Gly Thr Lys 
            580                 585                 590         


Ser Tyr Lys Arg Val Leu Thr Gly Lys Leu Ala Asp Phe Leu Ala Lys 
        595                 600                 605             


Asp Ile Val Lys Tyr Gln Pro Thr Leu Cys Ala Gly Asp Asp Tyr Gly 
    610                 615                 620                 


Ile Asp Arg Met Thr Gly Met Asn Tyr Arg Ile Met Gln Ala Thr Ile 
625                 630                 635                 640 


Ala Thr Tyr Asn Asp Asp Asp Asp Phe Asp Thr Phe Tyr Asn Val Phe 
                645                 650                 655     


Lys Met Ala Gly Leu Val Asp Gly Asp Glu Arg Lys Asn His Pro Phe 
            660                 665                 670         


Leu Lys Lys Val Leu Leu Ser Lys Pro Gln Asn Thr Val Ala Phe Asp 
        675                 680                 685             


Ile Lys Tyr Leu Lys Glu Lys Glu Ile Tyr Leu Arg Asn Ile Glu Lys 
    690                 695                 700                 


Lys Asn Ile Ile Pro Pro Phe Val Asn Arg Glu Arg Asn Lys Trp Cys 
705                 710                 715                 720 


Glu Arg Asp Cys Glu Tyr Tyr Arg Ile Leu Gly Glu Asn Leu Leu Asp 
                725                 730                 735     


Leu Pro Ile Glu Leu Pro Arg Gln Met Phe Tyr Lys Asp Ile Arg Ala 
            740                 745                 750         


Gln Leu Glu Pro Leu Met Pro Glu Ile Asp Phe Ser Gln Thr Asn Thr 
        755                 760                 765             


Thr Tyr Leu Ile Ala Glu Tyr Leu Lys Arg Val Arg Gly Asp Asp Phe 
    770                 775                 780                 


Gln Glu Phe Tyr Ser Trp Glu Arg Asn Tyr Arg Tyr Ile Asp Phe Leu 
785                 790                 795                 800 


Lys Cys Ile Arg Asp Asp Asn Gly Arg Ile Cys Ala Gln Tyr Thr Thr 
                805                 810                 815     


Thr Glu Glu Arg Glu Ser Leu Trp Glu Asp Ser Lys Asn Arg Thr Ala 
            820                 825                 830         


Glu Tyr Lys Arg Ser Glu Glu Gln Lys Asn Glu Lys Lys Asp Lys Asn 
        835                 840                 845             


Phe Glu Asp Ser Leu Glu Glu Arg Ile Ser Ser Ser His Ile Lys Phe 
    850                 855                 860                 


Gln Asn Thr Glu Lys His Ile Arg Arg Tyr Lys Val Gln Asp Ala Leu 
865                 870                 875                 880 


Leu Phe Met Ile Ala Glu Lys Gln Phe Gly Lys Tyr Leu Asp Asp Ile 
                885                 890                 895     


Lys Ala Lys Asn Phe Lys Leu Lys Asp Ile Met Pro Asp Thr Asp Lys 
            900                 905                 910         


Gly Ile Leu Ser Glu Thr Met Pro Ile Asp Phe Thr Phe Thr Lys Lys 
        915                 920                 925             


Asn Ile Lys Tyr Asn Ile His Ala Lys Asn Leu Lys Phe Lys Glu Tyr 
    930                 935                 940                 


Gly Asp Leu Phe Ile Leu Ala Asn Asp Lys Arg Leu Glu Ser Leu Trp 
945                 950                 955                 960 


Lys Ile Leu Ala Thr Asp Thr Val Asn Lys Glu Glu Ile Ser Glu Glu 
                965                 970                 975     


Phe Ala Lys Tyr Asp Phe Cys Arg Pro Asp Ile Thr Lys Leu Val Leu 
            980                 985                 990         


Asp Phe Glu Lys Asp Val Leu Glu  Lys Tyr Pro Glu Ile  Ile Glu Glu 
        995                 1000                 1005             


Ala Glu  Lys Glu Tyr Lys Lys  Phe Asp Phe Lys Phe  Ile Leu Asp 
    1010                 1015                 1020             


Trp Leu  Ile Asn Lys Lys Lys  Leu Asn Tyr Gly Ile  Arg Asn Lys 
    1025                 1030                 1035             


Leu Leu  Leu Ile Arg Asn Ala  Phe Asn His Asn Ser  Tyr Pro Asp 
    1040                 1045                 1050             


Lys Lys  Tyr Ala Glu Val Arg  Glu Leu Pro Glu Ile  Ala Thr Asn 
    1055                 1060                 1065             


Leu Lys  Lys Thr Phe Asp Glu  Asn Ala Lys Lys Tyr  Glu 
    1070                 1075                 1080     


<210>  2634
<211>  1029
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2634

Met His Val Thr Thr Thr Asn Lys Pro Leu Leu Ala Ala Tyr Leu Asn 
1               5                   10                  15      


Met Ala Arg Asn Asn Cys Tyr Met Ala Leu Ser His Ile Ala Glu Leu 
            20                  25                  30          


Met Gly Lys Ser Ser Val Met Asn Glu Asp Ala Ile Gln Glu Cys Ala 
        35                  40                  45              


Val Ile Arg Ala Leu Ala Gly Asn Ile Lys Pro Asp Glu Ser Phe Arg 
    50                  55                  60                  


Ile Ile Asp Met Val Asp Gln His Phe Pro Phe Ile Arg Leu Leu Leu 
65                  70                  75                  80  


Lys Ser Arg Asn Asn Ser Ser Pro Thr Asp Tyr Ala Asn Cys Leu Thr 
                85                  90                  95      


Asp Phe Ile Lys Gln Leu Asn Glu Leu Arg Asn Phe His Thr His Gln 
            100                 105                 110         


Leu His Lys Pro Tyr Ile Thr Asp Ala Lys Val Val Ala Gln Leu Gln 
        115                 120                 125             


Phe Leu Phe Asp Ala Ser Arg Arg Glu Val Lys Lys Arg Phe Ser Leu 
    130                 135                 140                 


Glu Glu Gln Asp Val Lys His Leu Val Arg Lys Ser Ile Val Ile Ile 
145                 150                 155                 160 


Asp Asn Asn Lys Val Ala Val Glu Lys Glu Asn Tyr Val Tyr Ala Phe 
                165                 170                 175     


Ala Asn Lys Glu Gly Gln Phe Thr Asn Lys Gly Ile Ala Phe Leu Ile 
            180                 185                 190         


Ser Leu Phe Ile Glu Lys Lys Tyr Ala Tyr Leu Phe Leu Lys Gln Leu 
        195                 200                 205             


Ser Gly Phe Lys Asn Ser Asn Thr Lys Gln His Lys Ala Thr Leu Glu 
    210                 215                 220                 


Val Phe Cys Phe Tyr His Ile Arg Ile Pro Gln Pro Lys Leu Gln Ser 
225                 230                 235                 240 


Asn Asn Thr Lys Ile Gly Phe Leu Leu Asp Ala Leu Glu Glu Leu Lys 
                245                 250                 255     


Arg Cys Pro Ala Glu Leu Tyr Glu His Ile Ala Lys Asn Asp Lys Gln 
            260                 265                 270         


Arg Phe Lys Ser Ala Gly Ile Thr Glu Asp Thr Asn Asp Gln Pro Glu 
        275                 280                 285             


Ala Ile Leu Lys Arg Asn Gly Asp Arg Phe Ser Tyr Leu Ala Leu Arg 
    290                 295                 300                 


Tyr Leu Glu Leu Thr Asn Ser Leu Pro Gly Leu Gln Phe Tyr Phe Asp 
305                 310                 315                 320 


Leu Gly Lys Tyr Tyr Phe Lys Val Tyr Glu Lys Ser Ile Asp Ser Glu 
                325                 330                 335     


Leu Arg Leu Arg Arg Leu His Lys Asn Met Arg Asp Phe Gly Arg Thr 
            340                 345                 350         


Asn Asp Phe Asp Thr Val Lys Met Pro Gln Leu Trp Gln Gln Leu Ile 
        355                 360                 365             


Lys Arg Thr Asp Glu Leu Ser Glu Asn Tyr Ala Glu Pro Tyr Ile Val 
    370                 375                 380                 


Tyr Thr Ile Pro His Tyr His Ile Val Asn Asn Gln Ile Gly Ile Trp 
385                 390                 395                 400 


Leu Asn Lys Glu Arg Gln Met Pro Ser Leu Thr Pro Lys Ile Ser Asn 
                405                 410                 415     


Ala Glu Pro Gln Ile Trp Leu Ser Leu Tyr Glu Leu Pro Ala Leu Leu 
            420                 425                 430         


Phe Tyr His Leu Leu Thr Lys Gly Asn Lys Gly Gln Lys Asn Val Leu 
        435                 440                 445             


Gln Ile Leu Ser Lys His Arg Thr Ala Ile His Ser Phe Phe Lys Asp 
    450                 455                 460                 


Ile Glu Ser Ser Lys Leu Leu Pro Gly Phe Thr Ile Glu Thr Leu Asn 
465                 470                 475                 480 


Val Glu Leu Glu Lys Arg Asn Leu Lys His Asp Lys Ile Pro Lys Pro 
                485                 490                 495     


Leu Leu Gln Tyr Leu Leu Gln Gln Lys Pro Leu Lys Ser Ile Val Glu 
            500                 505                 510         


Ile Ala Gly Glu Arg Leu Ser Glu Leu Gln Asn Glu Thr Ile Phe Leu 
        515                 520                 525             


Leu Asp Lys Ile Asp Ile Asp Ile Glu Lys Ala Lys Glu Lys Ile Gly 
    530                 535                 540                 


Gly Lys His Tyr Arg Pro Ile Gln Thr Gly Lys Ile Ala Asp Phe Leu 
545                 550                 555                 560 


Ala Arg Asp Met Leu Phe Phe Gln Pro Ala Ile Asp Lys Ile Lys Gly 
                565                 570                 575     


Lys Ala Thr Ser Thr Leu Phe Gln Val Leu Gln Ala Arg Leu Ala Phe 
            580                 585                 590         


Tyr Gly Arg Asp Lys Glu Leu Leu Glu Gly Leu Tyr Lys Glu Cys Asn 
        595                 600                 605             


Leu Ile Gln Ser Lys Asn Pro His Pro Phe Leu Ser Gly Leu Pro Ile 
    610                 615                 620                 


Thr Asn Asn Leu Met Asp Tyr Tyr Arg Asn Tyr Leu Ile Lys Arg Asn 
625                 630                 635                 640 


Gln Tyr Leu Asp Lys Cys Leu Lys Lys Cys Lys Gln Gly Lys Ile Gly 
                645                 650                 655     


Ser Gln Asp Phe His Phe Leu His Leu Gly Glu Arg Glu Arg Lys Asn 
            660                 665                 670         


Gly Asn Thr Tyr Tyr Thr Asn Leu Ala Gly Lys Phe Ile Lys Met Pro 
        675                 680                 685             


Leu Asn Phe Pro Arg Gly Leu Phe Met Glu Glu Leu Ile Asn Tyr Phe 
    690                 695                 700                 


Glu Ser Ser Gly Asp Leu His Met Gln Asn Ile Ile Lys Asn Thr Pro 
705                 710                 715                 720 


Arg Leu Ser Thr Thr Phe Leu Leu Lys Glu Tyr Ile Asn Asn Val Leu 
                725                 730                 735     


Ser Asp Asp Thr Pro Asp Phe Tyr Asn Trp Lys Arg Ser Tyr Thr Val 
            740                 745                 750         


Phe Asn Arg Tyr Tyr Asp Lys Arg Lys Gln Asn Ser Arg Asp Ala Ile 
        755                 760                 765             


Thr Lys Ile Tyr Phe Asp Thr Ser Gln Leu Ser Glu Glu Ala Asn Lys 
    770                 775                 780                 


Ile Lys Ala Ala Ile Lys Lys Ile Glu Lys Ser Asp Ile Lys Gly Ala 
785                 790                 795                 800 


Glu Ser Ile Lys Arg Asn Tyr Lys Phe Tyr Gly Asp Asn Glu Lys Gln 
                805                 810                 815     


Leu Arg Gln Ala Lys Ala Cys Asp Thr Ile Leu Phe Leu Ala Ile Arg 
            820                 825                 830         


Asp Leu Phe Pro Thr Ile Glu Ser Ser Val Phe Lys Gly Leu Ala Ile 
        835                 840                 845             


Glu Gln Phe Arg Leu Ser Asp Ile Leu Pro Asp Ala Glu Lys Gly Ile 
    850                 855                 860                 


Leu Ser Gln Ser Ile Glu Ile Arg Leu Pro Leu Tyr Asn Lys Phe Ile 
865                 870                 875                 880 


Ile Gln Lys Gly Leu Lys Leu Lys Asn Tyr Gly Asp Phe Arg Arg Phe 
                885                 890                 895     


Leu Lys Asp Arg Arg Leu Glu Ser Leu Met Pro Tyr Phe Glu Glu Asp 
            900                 905                 910         


Asp Ile Asp Arg Ser Ser Leu Glu Lys Glu Leu Glu Asp Tyr Asp Thr 
        915                 920                 925             


Ala Arg Ile Glu Ile His Arg Val Val Leu Asp Phe Glu Ser His Val 
    930                 935                 940                 


Ile Thr Met Tyr Gln Leu Asn Tyr Leu Asn Pro Glu Asp Pro Cys Ile 
945                 950                 955                 960 


Asn His Glu Thr Ile Leu Asn Cys Phe Phe Gln Asn Asp Pro Ser Asp 
                965                 970                 975     


Ile Arg Lys Gln Leu Met Glu Asn Ile Arg Asn Arg Phe Ser His Asn 
            980                 985                 990         


Glu Tyr Pro Asp Phe Glu Lys Phe  Lys Glu Ile Ile Gln  Glu Asn His 
        995                 1000                 1005             


Gln Gln  Lys Thr Ile Ala Gly  Lys Phe Val Thr Leu  Ala Asn Gln 
    1010                 1015                 1020             


Tyr Phe  Ser Val Glu Glu 
    1025                 


<210>  2635
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2635

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2636
<211>  1124
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2636

Met Thr Leu Pro Ile Asn Asn Thr Phe Thr Ser Arg Ala Asp Arg Glu 
1               5                   10                  15      


Ile Leu Ser Gln Asn Lys Leu Phe Phe Gly Thr Tyr Leu Asn Met Ala 
            20                  25                  30          


Gln His Asn Thr Phe Leu Met Leu Thr Asp Ser Ser Glu Lys Val Gly 
        35                  40                  45              


Lys Thr Pro Pro Ser Ser Glu Gly Leu Trp Lys Asp Ala Gly Thr Phe 
    50                  55                  60                  


Ser Leu Leu Asn Thr Gln Gln Arg Pro Ser Ile Arg Ser Lys Ala Gly 
65                  70                  75                  80  


Arg Leu Ala Val Lys Gln Phe Val Ala Leu Glu Ser Leu Val Ile Glu 
                85                  90                  95      


Arg Glu Glu Gly Glu Ala Glu Thr Pro Pro Asp Val Glu Lys Leu His 
            100                 105                 110         


Asp Phe Leu Tyr Ser Ala Leu Glu Leu Leu Asn Asn Leu Arg Arg Glu 
        115                 120                 125             


Tyr Ser His Tyr Tyr His Glu Thr Ala Gln Asn Ile Asp Tyr Pro Lys 
    130                 135                 140                 


Leu Glu Ala Ile Phe Arg Glu Ala Lys Arg Val Ala Ile Glu Arg Leu 
145                 150                 155                 160 


Pro Lys Asp Asp Asp Lys Ala Lys Asn Lys Ala Glu Lys Lys Ile Val 
                165                 170                 175     


Lys Tyr Met Leu Arg Asn Glu Asp Glu Lys Leu Val Phe Phe Ile Ser 
            180                 185                 190         


Leu Phe Leu Ser Arg Gln Gln Ala Glu Ala Phe Met Ser Gln Ile Asn 
        195                 200                 205             


Asp Phe Lys Gly Glu His Asn Ala Leu Lys Arg Arg Val Phe Ala Gln 
    210                 215                 220                 


Leu Cys Cys Arg Leu Pro Arg Pro Lys Leu Glu Ser Ala Ala Leu Glu 
225                 230                 235                 240 


Leu Asp Ala Leu Asn Glu Leu Ala Arg Cys Pro Asp Glu Val Phe Arg 
                245                 250                 255     


Tyr Leu Asn Thr Glu Asp Lys Asn Arg Phe Val Val Pro Leu Lys Glu 
            260                 265                 270         


Leu Asp Lys Asp Asp Thr Ser Gly Asn Thr Ile Thr Leu Lys Arg Tyr 
        275                 280                 285             


Glu Asp Arg Leu Pro Tyr Leu Leu Met Arg Tyr Leu Asp Glu His Ala 
    290                 295                 300                 


Glu Asn Phe Gly Ile His Phe Gln Ile Trp Ala Gly Lys Leu Arg Thr 
305                 310                 315                 320 


Ala Asp Tyr Pro Lys Thr Ile Tyr Asp Ile Glu Asp Asn Arg Asn Ile 
                325                 330                 335     


His Glu Asn Leu Thr Ala Tyr Asp Thr Leu Gln Asn Leu Arg Asn Gly 
            340                 345                 350         


Asp Asn Ile Pro Asp Asn Trp Lys Met Gln Asp Gly Glu Leu Leu Thr 
        355                 360                 365             


Lys Ile Glu Gln Phe Ser Pro His Tyr Asn Ile Ile Asn Asn Arg Ile 
    370                 375                 380                 


Ala Leu Lys Leu Gly Asp Thr Ala Tyr Thr Glu Ile Tyr Pro Leu Ser 
385                 390                 395                 400 


Glu Asp Ser Lys Leu Asp Phe Arg Val Lys Asn Pro Leu Pro Asp Leu 
                405                 410                 415     


Ile Ile Ser Thr Tyr Asp Ile Pro Asn Leu Phe Leu Tyr Gln Tyr Leu 
            420                 425                 430         


His Gln Gln Gly Lys Ile Arg Leu Arg Pro Asp Ile Phe Ile Arg Gln 
        435                 440                 445             


Phe Ser Gly Lys Leu Arg Lys Val Phe Lys Asp Val Gln Ser Gly Glu 
    450                 455                 460                 


Leu Lys Pro Leu Gln Ala Glu Ala Phe Glu Lys Gln Gln Arg Tyr Ser 
465                 470                 475                 480 


Glu Arg Arg Gln Glu Ile Leu Glu Glu Arg Arg Ser Gln Leu Gln Ala 
                485                 490                 495     


Ile Leu Asp Asn Lys Tyr Lys Leu Val Lys Val Ser His Leu Pro Asp 
            500                 505                 510         


Ala Leu Arg Glu Tyr Leu Phe Asn Tyr Lys Ala Gln Asp Phe Asn Arg 
        515                 520                 525             


Gln Val Leu His Lys Ile Thr Glu Arg Met Glu Ala Asp Trp Gln Arg 
    530                 535                 540                 


Lys Lys Lys Ala Glu Tyr Gly Ser Gly Thr Asp Glu Pro Glu Leu Lys 
545                 550                 555                 560 


Ala Gly Asn Ile Gly Thr Tyr Ile Ala Arg Asp Ile Val Ala Leu Gln 
                565                 570                 575     


Pro Pro Asn Pro Gln Glu Val Asn Leu Gly Lys Pro Asn Asn Asp Gln 
            580                 585                 590         


Tyr Asn Glu Leu Gln Glu Ser Ile Ala Tyr Phe Gly Arg Glu Tyr His 
        595                 600                 605             


Val Leu Pro Ala Tyr Leu Arg Lys Glu Leu Gly Val Met Gly Glu Arg 
    610                 615                 620                 


Asn Asp Lys Thr Lys His Pro Phe Leu Val His Leu Asn Trp Asn Lys 
625                 630                 635                 640 


Cys His Thr Ala Lys Glu Phe Tyr Ile Glu Tyr Leu Asp Val Lys Arg 
                645                 650                 655     


Arg Trp Met Arg Ala Val Arg Asp Asp Ile Lys Ala Val Ser Pro Gln 
            660                 665                 670         


Thr Glu Gln Pro His Phe Val Lys Met Gln Arg Asn Ala Lys His Phe 
        675                 680                 685             


Gly Ile Asn Ile Asn Lys Ser Ala Leu Thr Asp Glu Gln Ile Gln Glu 
    690                 695                 700                 


Arg Tyr Gly Tyr Phe Leu Arg Ile Asn Ser Lys Ala Ala Lys Asp Arg 
705                 710                 715                 720 


Asn Tyr Leu Lys Thr Met Arg Lys Asn Pro Ile Ser Gly Asp Phe Glu 
                725                 730                 735     


Pro Thr Asp Asn Ala Pro Ile Met Leu Pro Arg Gly Ile Phe Asn Asp 
            740                 745                 750         


Ala Ile Arg Glu Ala Leu Arg Thr Asn Tyr Pro Asp Gln Ile Asn Asp 
        755                 760                 765             


Lys Ser Gly Met Ser Asp Phe Thr Arg Ile Met Ala Asn Asp Glu Asp 
    770                 775                 780                 


Leu Gln Thr Cys Tyr Ser Tyr Pro Arg His Tyr Arg Tyr Glu Ala Asp 
785                 790                 795                 800 


Asn Asp Lys Leu Phe Lys Asn Asp Arg Glu Lys Ala Arg His Thr Ile 
                805                 810                 815     


Asp Ile Lys Gly Asp Thr Ala Gln Ile Trp Gln Gly Leu Cys Asp Leu 
            820                 825                 830         


Lys Thr Glu Leu Lys Asp Asn Leu Thr Arg Ala Lys Asn Ser Gln Leu 
        835                 840                 845             


Lys Arg Leu Phe Glu Gln Val Asp Arg Gln Lys Lys Leu Trp Arg Arg 
    850                 855                 860                 


Ile Phe Arg Asn Glu Gln Ala Ile Arg Thr Val Ala Phe Lys Asp Arg 
865                 870                 875                 880 


Leu Val Trp Leu Met Val Lys Asp Ile Leu Thr Arg Lys Ser Gln Ala 
                885                 890                 895     


Glu Gln Ser Asn Leu Gln Leu Glu Gln Trp Gln Leu Gln Asp Thr Gly 
            900                 905                 910         


Phe Asp Val Arg Lys Thr Glu Val Trp Ile Leu Asp Gln Ala Ile Pro 
        915                 920                 925             


Thr Ser Leu Thr Ile His Asp Lys Asp Ile Cys Ala Asn Phe Gln Ser 
    930                 935                 940                 


Ala Glu Leu Asp Lys Ala Arg Glu Asn Glu Leu Pro Val Lys Arg Tyr 
945                 950                 955                 960 


Gly Glu Phe Arg Lys Met Leu Lys Asp Arg Arg Leu Phe Val Ala Asn 
                965                 970                 975     


Asn Ser Gly Leu Leu Arg Tyr Tyr Pro Glu Lys Ser Ile Leu Trp Thr 
            980                 985                 990         


Thr Leu Gln Asp Glu Leu Arg Asp  Tyr Asp Gln Cys Arg  Ala Glu Leu 
        995                 1000                 1005             


Leu Asn  Ala Ile Phe Ala Phe  Glu Gln Arg Val Leu  Ser Asn Gln 
    1010                 1015                 1020             


Gln Cys  Arg Gln His Leu Ser  Leu Thr Glu Asn Arg  Ile Asp His 
    1025                 1030                 1035             


Lys Val  Tyr Leu Glu Ala Tyr  Lys Ala Thr Tyr Gly  Asn Met Pro 
    1040                 1045                 1050             


Gln Pro  Ile Ser Asn Ile Asn  Gln Leu Arg Asn Lys  Phe Met His 
    1055                 1060                 1065             


Asn Gln  Ile Pro Tyr Asp Thr  Trp Ile Ser Gln Ala  Ile Glu His 
    1070                 1075                 1080             


Asn Thr  Asn Ala Asn Leu Pro  Ile Glu Asp His Arg  Asn Lys Asn 
    1085                 1090                 1095             


Val Val  Lys Gln Leu Ile Glu  Phe Ala Thr Glu Leu  Tyr Asp Gly 
    1100                 1105                 1110             


Met Asn  Glu Ile Leu Phe Tyr  Asn Lys Glu Asn 
    1115                 1120                 


<210>  2637
<211>  1029
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2637

Met His Val Thr Thr Thr Asn Lys Pro Leu Leu Ala Ala Tyr Leu Asn 
1               5                   10                  15      


Met Ala Arg Asn Asn Cys Tyr Met Ala Leu Ser His Ile Ala Glu Leu 
            20                  25                  30          


Met Gly Lys Ser Ser Val Met Asn Glu Asp Ala Ile Gln Glu Cys Ala 
        35                  40                  45              


Val Ile Arg Ala Leu Ala Gly Asn Ile Lys Pro Asp Glu Ser Phe Arg 
    50                  55                  60                  


Ile Ile Asp Met Val Asp Gln His Phe Pro Phe Ile Arg Leu Leu Leu 
65                  70                  75                  80  


Lys Ser Arg Asn Asn Ser Ser Pro Thr Asp Tyr Ala Asn Cys Leu Thr 
                85                  90                  95      


Asp Phe Ile Lys Gln Leu Asn Glu Leu Arg Asn Phe His Thr His Gln 
            100                 105                 110         


Leu His Lys Pro Tyr Ile Thr Asp Ala Lys Val Val Ala Gln Leu Gln 
        115                 120                 125             


Phe Leu Phe Asp Ala Ser Arg Arg Glu Val Lys Lys Arg Phe Ser Leu 
    130                 135                 140                 


Glu Glu Gln Asp Val Lys His Leu Val Arg Lys Ser Ile Val Ile Ile 
145                 150                 155                 160 


Asp Asn Asn Lys Val Ala Val Glu Lys Glu Asn Tyr Val Tyr Ala Phe 
                165                 170                 175     


Ala Asn Lys Glu Gly Gln Phe Thr Asn Lys Gly Ile Ala Phe Leu Ile 
            180                 185                 190         


Ser Leu Phe Ile Glu Lys Lys Tyr Ala Tyr Leu Phe Leu Lys Gln Leu 
        195                 200                 205             


Ser Gly Phe Lys Asn Ser Asn Thr Lys Gln His Lys Ala Thr Leu Glu 
    210                 215                 220                 


Val Phe Cys Phe Tyr His Ile Arg Ile Pro Gln Pro Lys Leu Gln Ser 
225                 230                 235                 240 


Asn Asn Thr Lys Ile Gly Phe Leu Leu Asp Ala Leu Glu Glu Leu Lys 
                245                 250                 255     


Arg Cys Pro Ala Glu Leu Tyr Glu His Ile Ala Lys Asn Asp Lys Gln 
            260                 265                 270         


Arg Phe Lys Ser Ala Gly Ile Thr Glu Asp Thr Asn Asp Gln Pro Glu 
        275                 280                 285             


Ala Ile Leu Lys Arg Asn Gly Asp Arg Phe Ser Tyr Leu Ala Leu Arg 
    290                 295                 300                 


Tyr Leu Glu Leu Thr Asn Ser Leu Pro Gly Leu Gln Phe Tyr Phe Asp 
305                 310                 315                 320 


Leu Gly Lys Tyr Tyr Phe Lys Val Tyr Glu Lys Ser Ile Asp Ser Glu 
                325                 330                 335     


Leu Arg Leu Arg Arg Leu His Lys Asn Met Arg Asp Phe Gly Arg Thr 
            340                 345                 350         


Asn Asp Phe Asp Thr Val Lys Met Pro Gln Leu Trp Gln Gln Leu Ile 
        355                 360                 365             


Lys Arg Thr Asp Glu Leu Ser Glu Asn Tyr Ala Glu Pro Tyr Ile Val 
    370                 375                 380                 


Tyr Thr Ile Pro His Tyr His Ile Val Asn Asn Gln Ile Gly Ile Trp 
385                 390                 395                 400 


Leu Asn Lys Glu Arg Gln Met Pro Ser Leu Thr Pro Lys Ile Ser Asn 
                405                 410                 415     


Ala Glu Pro Gln Ile Trp Leu Ser Leu Tyr Glu Leu Pro Ala Leu Leu 
            420                 425                 430         


Phe Tyr His Leu Leu Thr Lys Gly Asn Lys Gly Gln Lys Asn Val Leu 
        435                 440                 445             


Gln Ile Leu Ser Lys His Arg Thr Ala Ile His Ser Phe Phe Lys Asp 
    450                 455                 460                 


Ile Glu Ser Ser Lys Leu Leu Pro Gly Phe Thr Ile Glu Thr Leu Asn 
465                 470                 475                 480 


Val Glu Leu Glu Lys Arg Asn Leu Lys His Asp Lys Ile Pro Lys Pro 
                485                 490                 495     


Leu Leu Gln Tyr Leu Leu Gln Gln Lys Pro Leu Lys Ser Ile Val Glu 
            500                 505                 510         


Ile Ala Gly Glu Arg Leu Ser Glu Leu Gln Asn Glu Thr Ile Phe Leu 
        515                 520                 525             


Leu Asp Lys Ile Asp Ile Asp Ile Glu Lys Ala Lys Glu Lys Ile Gly 
    530                 535                 540                 


Gly Lys His Tyr Arg Pro Ile Gln Thr Gly Lys Ile Ala Asp Phe Leu 
545                 550                 555                 560 


Ala Arg Asp Met Leu Phe Phe Gln Pro Ala Ile Asp Lys Ile Lys Gly 
                565                 570                 575     


Lys Ala Thr Ser Thr Leu Phe Gln Val Leu Gln Ala Arg Leu Ala Phe 
            580                 585                 590         


Tyr Gly Arg Asp Lys Glu Leu Leu Glu Gly Leu Tyr Lys Glu Cys Asn 
        595                 600                 605             


Leu Ile Gln Ser Lys Asn Pro His Pro Phe Leu Ser Gly Leu Pro Ile 
    610                 615                 620                 


Thr Asn Asn Leu Met Asp Tyr Tyr Arg Asn Tyr Leu Ile Lys Arg Asn 
625                 630                 635                 640 


Gln Tyr Leu Asp Lys Cys Leu Lys Lys Cys Lys Gln Gly Lys Ile Gly 
                645                 650                 655     


Ser Gln Asp Phe His Phe Leu His Leu Gly Glu Arg Glu Arg Lys Asn 
            660                 665                 670         


Gly Asn Thr Tyr Tyr Thr Asn Leu Ala Gly Lys Phe Ile Lys Met Pro 
        675                 680                 685             


Leu Asn Phe Pro Arg Gly Leu Phe Met Glu Glu Leu Ile Asn Tyr Phe 
    690                 695                 700                 


Glu Ser Ser Gly Asp Leu His Met Gln Asn Ile Ile Lys Asn Thr Pro 
705                 710                 715                 720 


Arg Leu Ser Thr Thr Phe Leu Leu Lys Glu Tyr Ile Asn Asn Val Leu 
                725                 730                 735     


Ser Asp Asp Thr Pro Asp Phe Tyr Asn Trp Lys Arg Ser Tyr Thr Val 
            740                 745                 750         


Phe Asn Arg Tyr Tyr Asp Lys Arg Lys Gln Asn Ser Arg Asp Ala Ile 
        755                 760                 765             


Thr Lys Ile Tyr Phe Asp Thr Ser Gln Leu Ser Glu Glu Ala Asn Lys 
    770                 775                 780                 


Ile Lys Ala Ala Ile Lys Lys Ile Glu Lys Ser Asp Ile Lys Gly Ala 
785                 790                 795                 800 


Glu Ser Ile Lys Arg Asn Tyr Lys Phe Tyr Gly Asp Asn Glu Lys Gln 
                805                 810                 815     


Leu Arg Gln Ala Lys Ala Cys Asp Thr Ile Leu Phe Leu Ala Ile Arg 
            820                 825                 830         


Asp Leu Phe Pro Thr Ile Glu Ser Ser Val Phe Lys Gly Leu Ala Ile 
        835                 840                 845             


Glu Gln Phe Arg Leu Ser Asp Ile Leu Pro Asp Ala Glu Lys Gly Ile 
    850                 855                 860                 


Leu Ser Gln Ser Ile Glu Ile Arg Leu Pro Leu Tyr Asn Lys Phe Ile 
865                 870                 875                 880 


Ile Gln Lys Gly Leu Lys Leu Lys Asn Tyr Gly Asp Phe Arg Arg Phe 
                885                 890                 895     


Leu Lys Asp Arg Arg Leu Glu Ser Leu Met Pro Tyr Phe Glu Glu Asp 
            900                 905                 910         


Asp Ile Asp Arg Ser Ser Leu Glu Lys Glu Leu Glu Asp Tyr Asp Thr 
        915                 920                 925             


Ala Arg Ile Glu Ile His Arg Val Val Leu Asp Phe Glu Ser His Val 
    930                 935                 940                 


Ile Thr Met Tyr Gln Leu Asn Tyr Leu Asn Pro Glu Asp Pro Cys Ile 
945                 950                 955                 960 


Asn His Glu Thr Ile Leu Asn Cys Phe Phe Gln Asn Asp Pro Ser Asp 
                965                 970                 975     


Ile Arg Lys Gln Leu Met Glu Asn Ile Arg Asn Arg Phe Ser His Asn 
            980                 985                 990         


Glu Tyr Pro Asp Phe Glu Lys Phe  Lys Glu Ile Ile Gln  Glu Asn His 
        995                 1000                 1005             


Gln Gln  Lys Thr Ile Ala Gly  Lys Phe Val Thr Leu  Ala Asn Gln 
    1010                 1015                 1020             


Tyr Phe  Ser Val Glu Glu 
    1025                 


<210>  2638
<211>  1124
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2638

Met Thr Leu Pro Ile Asn Asn Thr Phe Thr Ser Arg Ala Asp Arg Glu 
1               5                   10                  15      


Ile Leu Ser Gln Asn Lys Leu Phe Phe Gly Thr Tyr Leu Asn Met Ala 
            20                  25                  30          


Gln His Asn Thr Phe Leu Met Leu Thr Asp Ser Ser Glu Lys Val Gly 
        35                  40                  45              


Lys Thr Pro Pro Ser Ser Glu Gly Leu Trp Lys Asp Ala Gly Thr Phe 
    50                  55                  60                  


Ser Leu Leu Asn Thr Gln Gln Arg Pro Ser Ile Arg Ser Lys Ala Gly 
65                  70                  75                  80  


Arg Leu Ala Val Lys Gln Phe Val Ala Leu Glu Ser Leu Val Ile Glu 
                85                  90                  95      


Arg Glu Glu Gly Glu Ala Glu Thr Pro Pro Asp Val Glu Lys Leu His 
            100                 105                 110         


Asp Phe Leu Tyr Ser Ala Leu Glu Leu Leu Asn Asn Leu Arg Arg Glu 
        115                 120                 125             


Tyr Ser His Tyr Tyr His Glu Thr Ala Gln Asn Ile Asp Tyr Pro Lys 
    130                 135                 140                 


Leu Glu Ala Ile Phe Arg Glu Ala Lys Arg Val Ala Ile Glu Arg Leu 
145                 150                 155                 160 


Pro Lys Asp Asp Asp Lys Ala Lys Asn Lys Ala Glu Lys Lys Ile Val 
                165                 170                 175     


Lys Tyr Met Leu Arg Asn Glu Asp Glu Lys Leu Val Phe Phe Ile Ser 
            180                 185                 190         


Leu Phe Leu Ser Arg Gln Gln Ala Glu Ala Phe Met Ser Gln Ile Asn 
        195                 200                 205             


Asp Phe Lys Gly Glu His Asn Ala Leu Lys Arg Arg Val Phe Ala Gln 
    210                 215                 220                 


Leu Cys Cys Arg Leu Pro Arg Pro Lys Leu Glu Ser Ala Ala Leu Glu 
225                 230                 235                 240 


Leu Asp Ala Leu Asn Glu Leu Ala Arg Cys Pro Asp Glu Val Phe Arg 
                245                 250                 255     


Tyr Leu Asn Thr Glu Asp Lys Asn Arg Phe Val Val Pro Leu Lys Glu 
            260                 265                 270         


Leu Asp Lys Asp Asp Thr Ser Gly Asn Thr Ile Thr Leu Lys Arg Tyr 
        275                 280                 285             


Glu Asp Arg Leu Pro Tyr Leu Leu Met Arg Tyr Leu Asp Glu His Ala 
    290                 295                 300                 


Glu Asn Phe Gly Ile His Phe Gln Ile Trp Ala Gly Lys Leu Arg Thr 
305                 310                 315                 320 


Ala Asp Tyr Pro Lys Thr Ile Tyr Asp Ile Glu Asp Asn Arg Asn Ile 
                325                 330                 335     


His Glu Asn Leu Thr Ala Tyr Asp Thr Leu Gln Asn Leu Arg Asn Gly 
            340                 345                 350         


Asp Asn Ile Pro Asp Asn Trp Lys Met Gln Asp Gly Glu Leu Leu Thr 
        355                 360                 365             


Lys Ile Glu Gln Phe Ser Pro His Tyr Asn Ile Ile Asn Asn Arg Ile 
    370                 375                 380                 


Ala Leu Lys Leu Gly Asp Thr Ala Tyr Thr Glu Ile Tyr Pro Leu Ser 
385                 390                 395                 400 


Glu Asp Ser Lys Leu Asp Phe Arg Val Lys Asn Pro Leu Pro Asp Leu 
                405                 410                 415     


Ile Ile Ser Thr Tyr Asp Ile Pro Asn Leu Phe Leu Tyr Gln Tyr Leu 
            420                 425                 430         


His Gln Gln Gly Lys Ile Arg Leu Arg Pro Asp Ile Phe Ile Arg Gln 
        435                 440                 445             


Phe Ser Gly Lys Leu Arg Lys Val Phe Lys Asp Val Gln Ser Gly Glu 
    450                 455                 460                 


Leu Lys Pro Leu Gln Ala Glu Ala Phe Glu Lys Gln Gln Arg Tyr Ser 
465                 470                 475                 480 


Glu Arg Arg Gln Glu Ile Leu Glu Glu Arg Arg Ser Gln Leu Gln Ala 
                485                 490                 495     


Ile Leu Asp Asn Lys Tyr Lys Leu Val Lys Val Ser His Leu Pro Asp 
            500                 505                 510         


Ala Leu Arg Glu Tyr Leu Phe Asn Tyr Lys Ala Gln Asp Phe Asn Arg 
        515                 520                 525             


Gln Val Leu His Lys Ile Thr Glu Arg Met Glu Ala Asp Trp Gln Arg 
    530                 535                 540                 


Lys Lys Lys Ala Glu Tyr Gly Ser Gly Thr Asp Glu Pro Glu Leu Lys 
545                 550                 555                 560 


Ala Gly Asn Ile Gly Thr Tyr Ile Ala Arg Asp Ile Val Ala Leu Gln 
                565                 570                 575     


Pro Pro Asn Pro Gln Glu Val Asn Leu Gly Lys Pro Asn Asn Asp Gln 
            580                 585                 590         


Tyr Asn Glu Leu Gln Glu Ser Ile Ala Tyr Phe Gly Arg Glu Tyr His 
        595                 600                 605             


Val Leu Pro Ala Tyr Leu Arg Lys Glu Leu Gly Val Met Gly Glu Arg 
    610                 615                 620                 


Asn Asp Lys Thr Lys His Pro Phe Leu Val His Leu Asn Trp Asn Lys 
625                 630                 635                 640 


Cys His Thr Ala Lys Glu Phe Tyr Ile Glu Tyr Leu Asp Val Lys Arg 
                645                 650                 655     


Arg Trp Met Arg Ala Val Arg Asp Asp Ile Lys Ala Val Ser Pro Gln 
            660                 665                 670         


Thr Glu Gln Pro His Phe Val Lys Met Gln Arg Asn Ala Lys His Phe 
        675                 680                 685             


Gly Ile Asn Ile Asn Lys Ser Ala Leu Thr Asp Glu Gln Ile Gln Glu 
    690                 695                 700                 


Arg Tyr Gly Tyr Phe Leu Arg Ile Asn Ser Lys Ala Ala Lys Asp Arg 
705                 710                 715                 720 


Asn Tyr Leu Lys Thr Met Arg Lys Asn Pro Ile Ser Gly Asp Phe Glu 
                725                 730                 735     


Pro Thr Asp Asn Ala Pro Ile Met Leu Pro Arg Gly Ile Phe Asn Asp 
            740                 745                 750         


Ala Ile Arg Glu Ala Leu Arg Thr Asn Tyr Pro Asp Gln Ile Asn Asp 
        755                 760                 765             


Lys Ser Gly Met Ser Asp Phe Thr Arg Ile Met Ala Asn Asp Glu Asp 
    770                 775                 780                 


Leu Gln Thr Cys Tyr Ser Tyr Pro Arg His Tyr Arg Tyr Glu Ala Asp 
785                 790                 795                 800 


Asn Asp Lys Leu Phe Lys Asn Asp Arg Glu Lys Ala Arg His Thr Ile 
                805                 810                 815     


Asp Ile Lys Gly Asp Thr Ala Gln Ile Trp Gln Gly Leu Cys Asp Leu 
            820                 825                 830         


Lys Thr Glu Leu Lys Asp Asn Leu Thr Arg Ala Lys Asn Ser Gln Leu 
        835                 840                 845             


Lys Arg Leu Phe Glu Gln Val Asp Arg Gln Lys Lys Leu Trp Arg Arg 
    850                 855                 860                 


Ile Phe Arg Asn Glu Gln Ala Ile Arg Thr Val Ala Phe Lys Asp Arg 
865                 870                 875                 880 


Leu Val Trp Leu Met Val Lys Asp Ile Leu Thr Arg Lys Ser Gln Ala 
                885                 890                 895     


Glu Gln Ser Asn Leu Gln Leu Glu Gln Trp Gln Leu Gln Asp Thr Gly 
            900                 905                 910         


Phe Asp Val Arg Lys Thr Glu Val Trp Ile Leu Asp Gln Ala Ile Pro 
        915                 920                 925             


Thr Ser Leu Thr Ile His Asp Lys Asp Ile Cys Ala Asn Phe Gln Ser 
    930                 935                 940                 


Ala Glu Leu Asp Lys Ala Arg Glu Asn Glu Leu Pro Val Lys Arg Tyr 
945                 950                 955                 960 


Gly Glu Phe Arg Lys Met Leu Lys Asp Arg Arg Leu Phe Val Ala Asn 
                965                 970                 975     


Asn Ser Gly Leu Leu Arg Tyr Tyr Pro Glu Lys Ser Ile Leu Trp Thr 
            980                 985                 990         


Thr Leu Gln Asp Glu Leu Arg Asp  Tyr Asp Gln Cys Arg  Ala Glu Leu 
        995                 1000                 1005             


Leu Asn  Ala Ile Phe Ala Phe  Glu Gln Arg Val Leu  Ser Asn Gln 
    1010                 1015                 1020             


Gln Cys  Arg Gln His Leu Ser  Leu Thr Glu Asn Arg  Ile Asp His 
    1025                 1030                 1035             


Lys Val  Tyr Leu Glu Ala Tyr  Lys Ala Thr Tyr Gly  Asn Met Pro 
    1040                 1045                 1050             


Gln Pro  Ile Ser Asn Ile Asn  Gln Leu Arg Asn Lys  Phe Met His 
    1055                 1060                 1065             


Asn Gln  Ile Pro Tyr Asp Thr  Trp Ile Ser Gln Ala  Ile Glu His 
    1070                 1075                 1080             


Asn Thr  Asn Ala Asn Leu Pro  Ile Glu Asp His Arg  Asn Lys Asn 
    1085                 1090                 1095             


Val Val  Lys Gln Leu Ile Glu  Phe Ala Thr Glu Leu  Tyr Asp Gly 
    1100                 1105                 1110             


Met Asn  Glu Ile Leu Phe Tyr  Asn Lys Glu Asn 
    1115                 1120                 


<210>  2639
<211>  1196
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2639

Met Lys Thr Ser Lys Glu Phe Glu Asn Tyr Asn Ser Arg Asn Ser Phe 
1               5                   10                  15      


Lys Lys Ile Phe Asp Phe Lys Gly Glu Ile Ala Pro Ile Ala Glu Lys 
            20                  25                  30          


Ala Asn Arg Asn Leu Glu Leu Lys Thr Lys Asn Glu Thr Asn Leu Val 
        35                  40                  45              


Gln Arg Val His Tyr Phe Ala Ile Gly His Thr Phe Lys Tyr Ile Asp 
    50                  55                  60                  


Thr Glu Thr Leu Phe Glu Trp Val Val Asp Glu Glu Thr Gln Met Lys 
65                  70                  75                  80  


Gln Pro Thr Lys Phe Leu Ser Leu Gln Ser Phe Asp Asp Ser Phe Cys 
                85                  90                  95      


Asp Glu Leu Gln Lys Ile Thr Val Val Gly Thr Asn Asn Glu Tyr Asn 
            100                 105                 110         


Gly Leu Ile Pro Ala Ile Arg Asn Ile Asn Ser His Tyr Ile His Ser 
        115                 120                 125             


Phe Glu Lys Ile Arg Ile Asp Ser Leu Ser Pro Val Met Val Lys Phe 
    130                 135                 140                 


Leu Lys Glu Ser Phe Glu Leu Ser Val Ile Gln Ile Tyr Ile Lys Glu 
145                 150                 155                 160 


Glu Asn Glu Leu Lys Arg Ser Lys Asn Glu Arg Leu Ala Ser Thr Lys 
                165                 170                 175     


Glu Ile Ile Glu Gln Asn Gly Phe Gly Lys Arg Leu Val Gln Phe Leu 
            180                 185                 190         


Cys Asp Lys Phe Tyr Pro Val Gly Asn Lys Thr Thr Tyr Pro Glu Asp 
        195                 200                 205             


Tyr Leu Glu Tyr Arg Lys Gln Phe Arg Asn Leu Ser Lys Asp Glu Ala 
    210                 215                 220                 


Ile Asp Ser Leu Leu Phe Val Glu Val Glu Thr Ala Phe Asp Trp Leu 
225                 230                 235                 240 


Leu Phe Glu Thr Tyr Pro Ala Phe Asn Ile Ala Val Gly Lys Tyr Leu 
                245                 250                 255     


Ser Phe Tyr Ser Cys Leu Phe Leu Leu Ser Met Phe Leu Tyr Lys Ser 
            260                 265                 270         


Glu Ala Asn Gln Leu Ile Ser Lys Ile Lys Gln Phe Lys Arg Asn Lys 
        275                 280                 285             


Ile Gln Glu Glu Lys Ser Lys Arg Glu Ile Phe Thr Phe Phe Ser Lys 
    290                 295                 300                 


Arg Phe Ser Ser Gln Asp Ile Asp Ser Glu Glu Asn His Leu Val Lys 
305                 310                 315                 320 


Phe Arg Asp Leu Ile Gln Tyr Leu Asn Arg Tyr Pro Val Ala Trp Asn 
                325                 330                 335     


Lys Asp Ile Glu Leu Glu Ser Gln His Pro Val Met Thr Asp Arg Leu 
            340                 345                 350         


Lys Ala Lys Ile Ile Glu Met Glu Ile Asp Ser Ser Phe Pro Ile Tyr 
        355                 360                 365             


Ala Glu Asn Asn Arg Phe His Val Phe Ala Lys Tyr Gln Ile Trp Gly 
    370                 375                 380                 


Lys Lys Tyr Phe Gly Lys Lys Ile Glu Lys Glu Tyr Ile Glu Gln Ser 
385                 390                 395                 400 


Phe Asn Gly Asn Glu Val Glu Glu Phe Ser Tyr Glu Ile Asn Thr Ser 
                405                 410                 415     


Pro Glu Leu Lys Gly Phe Tyr Leu Lys Leu Ala Asp Leu Lys Ser Lys 
            420                 425                 430         


Pro Gly Leu Tyr Glu Lys His Lys Ala Glu Ile Lys Arg Thr Glu Thr 
        435                 440                 445             


Ser Ile Lys Glu Leu Ile Glu Gln Asn Val Pro Asn Pro Ile Thr Glu 
    450                 455                 460                 


Lys Leu Lys Thr Arg Ile Glu Lys Asn Leu Leu Phe Val Ser Tyr Gly 
465                 470                 475                 480 


Arg Asn Gln Asp Arg Phe Met Asp Phe Ala Thr Arg Tyr Leu Ala Glu 
                485                 490                 495     


Thr Asn Tyr Phe Gly Asn Asp Ala Arg Phe Lys Met Tyr Gln Phe Tyr 
            500                 505                 510         


Thr Thr Thr Glu Gln Asn Lys Glu Tyr Glu Asn Leu Lys Glu Val Lys 
        515                 520                 525             


Ser Lys Lys Glu Ile Asp Arg Leu Lys Phe His His Gly Arg Pro Ile 
    530                 535                 540                 


His Phe Ser Thr Tyr Ser Asn His His Lys Arg Tyr Glu Ser Trp Asp 
545                 550                 555                 560 


Thr Pro Phe Val Phe Glu Asn Asn Ala Ile Gln Val Lys Met Thr Leu 
                565                 570                 575     


Asp His Gly Ile Glu Lys Thr Val Ser Ile Gln Arg Ser Leu Met Val 
            580                 585                 590         


Tyr Leu Leu Glu Asp Ala Leu Phe Lys Ala Asp Lys Ser Met Val Asp 
        595                 600                 605             


Ser Ala Gly Lys His Leu Ile Ser Glu Tyr Phe Thr His Gln Gln Gln 
    610                 615                 620                 


Asp Phe Asn Tyr Ser Arg Leu Val Leu Glu Gln Asn Glu Ser Ile Asn 
625                 630                 635                 640 


Thr Glu Gln Lys Asn Lys Phe Lys Lys Ile Leu Pro Lys Arg Leu Leu 
                645                 650                 655     


Asn His Tyr Leu Pro Ala Ile Gln Asn Asn Thr Pro Ala Phe Ser Thr 
            660                 665                 670         


Leu Gln Leu Ile Leu Glu Lys Ala Lys Leu Ala Glu Glu Arg Tyr Lys 
        675                 680                 685             


Lys Leu Thr Glu Lys Val Lys Thr Glu Gly Asn Tyr Asp Asp Phe Ile 
    690                 695                 700                 


Lys Arg Asn Lys Gly Lys Gln Phe Lys Leu Gln Phe Ile Arg Lys Ala 
705                 710                 715                 720 


Trp His Leu Met Tyr Phe Lys Glu Ser Tyr Lys Gln Gln Ala Ser Phe 
                725                 730                 735     


Ser Gly His His Lys Arg Phe His Ile Glu Arg Asp Glu Phe Asn Asp 
            740                 745                 750         


Phe Ser Arg Phe Met Phe Ala Phe Asp Glu Val Pro Ala Tyr Lys Asp 
        755                 760                 765             


Tyr Leu Lys Gln Leu Leu Asp Lys Lys Gly Phe Phe Glu Asn Gln Gln 
    770                 775                 780                 


Phe Lys Ala Leu Phe Glu Asn Gly Thr Ser Leu Asp Asn Leu Tyr Val 
785                 790                 795                 800 


Lys Thr Lys Gln Ala Tyr Glu Lys Trp Leu Ile Gly Gln Asn Asn Arg 
                805                 810                 815     


Glu Leu Glu Ala Thr Lys Tyr Thr Leu Gln Ser Tyr Glu Gln Phe Phe 
            820                 825                 830         


Ala Asp Asp Met Phe Tyr Ile Asn Gln Ser His Phe Ile Ser Phe Leu 
        835                 840                 845             


Glu Ser Lys Ser Leu Leu Ser Arg Asp Glu Gln Gly Gln Met Arg Phe 
    850                 855                 860                 


Asn Ala Leu Ala Asn Cys Ala Phe Leu Val Ser Glu Phe Tyr Tyr Thr 
865                 870                 875                 880 


Asp Lys Leu Asp Lys Thr Glu Tyr Lys Thr Asn Arg Lys Leu Phe Asn 
                885                 890                 895     


Gln Leu Arg Ser Val Arg Leu Glu Asp Ala Leu Leu Tyr Glu Met Ala 
            900                 905                 910         


Met Cys Tyr Leu Lys Ile Asp Gln Gln Val Val Gln Lys Ala Lys Ala 
        915                 920                 925             


His Val Ile Glu Ile Leu Thr Gln Asn Val Gln Phe Asp Ile Cys Asn 
    930                 935                 940                 


Ser Gln Asp Lys Leu Val Tyr His Leu Val Ile Pro Phe Asn Lys Ile 
945                 950                 955                 960 


Asp Ala Tyr Val Glu Leu Leu Asn Arg Lys Glu Thr Asp Glu Thr Ile 
                965                 970                 975     


Ser Ser Gly Ser Ser Phe Ile Thr Asn Val Asp Lys Tyr Ile Glu Met 
            980                 985                 990         


Ile Trp Asn Glu Ile Pro Trp Lys  Glu Lys Asn Glu Asn  Ala Lys Lys 
        995                 1000                 1005             


Ile Thr  His Ala Ala Met Tyr  Pro Ile Gly Glu Lys  Tyr Ser Arg 
    1010                 1015                 1020             


Gln Lys  Thr Ile Thr Tyr Asp  Asp Leu Gln Lys Ile  Tyr Gln His 
    1025                 1030                 1035             


Leu Leu  Ser Ser Ser Asn Lys  Leu Thr Asn Val Ser  Met Gln Ile 
    1040                 1045                 1050             


Glu Arg  Tyr Tyr Leu Cys Lys  Pro Asp Gly Gln Gly  His Val Val 
    1055                 1060                 1065             


Phe Asn  Gly Glu Thr Asp Arg  Lys Thr Gly Cys Tyr  Leu Ile Arg 
    1070                 1075                 1080             


Phe Glu  Lys Thr Gly Val Pro  Lys Thr Tyr Phe Gly  Val Gly Glu 
    1085                 1090                 1095             


Leu Asn  Ile Arg Asn Lys Ala  Phe His Phe Leu Ile  Thr Pro Ser 
    1100                 1105                 1110             


Lys Ser  Tyr Glu Lys Trp Leu  Met Asp Val Glu Arg  Glu Phe Ile 
    1115                 1120                 1125             


Leu Lys  Glu Val Lys Pro Asn  Asn Pro Lys Ala Tyr  Thr Asp Leu 
    1130                 1135                 1140             


Asn Arg  Ser Val Lys Leu Val  Cys Asp Ile Leu Leu  Asn Thr Leu 
    1145                 1150                 1155             


His Asn  Asn Tyr Phe Lys Leu  Thr Asp Ser Asp Lys  Gly Ile Pro 
    1160                 1165                 1170             


Lys Glu  Glu Gln Gly Lys Gln  Lys Gln Lys Asn Ala  Gln Ile Thr 
    1175                 1180                 1185             


Tyr Phe  Thr Lys His Ile Leu  Tyr 
    1190                 1195     


<210>  2640
<211>  1119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2640

Met Glu Asp Asp Lys Lys Thr Lys Glu Ser Thr Asn Met Leu Asp Asn 
1               5                   10                  15      


Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val Tyr 
            20                  25                  30          


Ile Thr Val Asn His Ile Asn Lys Ile Leu Glu Glu Gly Glu Ile Asn 
        35                  40                  45              


Arg Asp Gly Tyr Glu Thr Thr Leu Lys Asn Ser Trp Asp Glu Ile Lys 
    50                  55                  60                  


Asp Ile Asn Lys Lys Asp Arg Leu Ser Lys Leu Ile Ile Lys His Phe 
65                  70                  75                  80  


Pro Phe Leu Glu Ala Ala Thr Tyr Arg Gln Asn Pro Thr Asp Thr Thr 
                85                  90                  95      


Lys Gln Lys Glu Glu Lys Gln Ala Glu Ala Gln Ser Leu Glu Ser Leu 
            100                 105                 110         


Lys Lys Ser Phe Phe Val Phe Ile Tyr Lys Leu Arg Asp Leu Arg Asn 
        115                 120                 125             


His Tyr Ser His Tyr Lys His Ser Lys Ser Leu Glu Arg Pro Lys Phe 
    130                 135                 140                 


Glu Glu Asp Leu Gln Glu Lys Met Tyr Asn Ile Phe Asp Val Ser Ile 
145                 150                 155                 160 


Cys Leu Val Lys Lys Asp Tyr Gln Tyr Asn Lys Asp Ile Asn Pro Asp 
                165                 170                 175     


Glu Asp Phe Lys His Leu Asp Arg Lys Arg Lys Gly Lys Phe Lys Tyr 
            180                 185                 190         


Ser Phe Ala Asp Asn Glu Gly Asn Ile Thr Glu Ser Gly Leu Leu Phe 
        195                 200                 205             


Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Val Gln Lys 
    210                 215                 220                 


Lys Leu Glu Gly Phe Lys Cys Ser Asn Glu Ser Tyr Gln Lys Met Thr 
225                 230                 235                 240 


Asn Glu Val Phe Cys Arg Ser Arg Met Leu Leu Pro Lys Leu Arg Leu 
                245                 250                 255     


Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu Asn Glu 
            260                 265                 270         


Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Arg Gly Asp Asp 
        275                 280                 285             


Arg Glu Lys Phe Arg Val Pro Leu Asp Pro Ile Asp Glu Asp Tyr Asp 
    290                 295                 300                 


Ala Glu Gln Glu Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg 
305                 310                 315                 320 


Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Tyr Asn Glu Ile Phe Thr 
                325                 330                 335     


Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile Tyr 
            340                 345                 350         


Lys Lys Leu Ile Gly Gly Gln Lys Glu Asp Arg His Leu Thr His Lys 
        355                 360                 365             


Leu Tyr Gly Phe Glu Arg Ile Gln Glu Phe Asp Lys Gln Asn Arg Pro 
    370                 375                 380                 


Asp Glu Trp Lys Ala Ile Val Lys Asp Ser Asp Thr Phe Lys Lys Lys 
385                 390                 395                 400 


Glu Glu Lys Glu Glu Glu Lys Pro Tyr Ile Ser Glu Thr Thr Pro His 
                405                 410                 415     


Tyr His Leu Glu Asn Lys Lys Ile Gly Ile Ala Phe Lys Asn His Asn 
            420                 425                 430         


Ile Trp Pro Ser Thr Gln Thr Glu Leu Thr Asn Asn Lys Arg Lys Lys 
        435                 440                 445             


Tyr Asn Leu Gly Thr Ser Ile Lys Ala Glu Ala Phe Leu Ser Val His 
    450                 455                 460                 


Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Lys Thr Glu Asn 
465                 470                 475                 480 


Thr Lys Asn Asp Asn Lys Val Glu Gly Lys Lys Glu Thr Lys Lys Gln 
                485                 490                 495     


Glu Lys His Lys Ile Glu Ser Ile Ile Glu Ser Lys Ile Lys Asp Met 
            500                 505                 510         


Tyr Ala Leu Tyr Asp Ala Phe Ala Asn Gly Glu Ile Asn Ser Glu Lys 
        515                 520                 525             


Glu Leu Glu Glu Tyr Leu Lys Gly Lys Asp Ile Glu Ile Val His Leu 
    530                 535                 540                 


Pro Lys Gln Met Ile Ala Ile Leu Lys Asn Glu His Lys Asp Met Ala 
545                 550                 555                 560 


Glu Lys Ala Glu Ala Lys Gln Glu Lys Met Lys Leu Ala Thr Glu Asn 
                565                 570                 575     


Arg Leu Lys Thr Leu Asp Lys Gln Leu Lys Gly Lys Ile Gln Asn Gly 
            580                 585                 590         


Lys Arg Tyr Asn Ser Ala Pro Lys Ser Gly Glu Ile Ala Ser Trp Leu 
        595                 600                 605             


Val Asn Asp Met Met Arg Phe Gln Pro Val Gln Arg Asp Glu Asn Gly 
    610                 615                 620                 


Glu Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln Leu Leu 
625                 630                 635                 640 


Gln Arg Thr Leu Ala Phe Phe Gly Ser Glu His Glu Arg Leu Ala Pro 
                645                 650                 655     


Tyr Phe Lys Gln Thr Lys Leu Ile Glu Ser Ser Asn Pro His Pro Phe 
            660                 665                 670         


Leu Asn Asp Thr Glu Trp Glu Lys Cys Ser Asn Ile Leu Ser Phe Tyr 
        675                 680                 685             


Arg Ser Tyr Leu Lys Ala Lys Lys Asn Phe Leu Glu Ser Leu Lys Pro 
    690                 695                 700                 


Glu Asp Trp Glu Lys Asn Gln Tyr Phe Leu Met Leu Lys Glu Pro Lys 
705                 710                 715                 720 


Thr Asn Arg Lys Thr Leu Val Gln Gly Trp Lys Asn Gly Phe Asn Leu 
                725                 730                 735     


Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg Lys Trp Phe Met Glu His 
            740                 745                 750         


Trp Lys Asn Ile Lys Val Asp Asp Ser Lys Arg Val Gly Leu Val Ala 
        755                 760                 765             


Lys Val Ile Pro Leu Phe Phe Ser Glu Lys Tyr Lys Asp Ser Val Gln 
    770                 775                 780                 


Pro Phe Tyr Asn Tyr Pro Phe Asn Val Gly Asp Val Asn Lys Pro Lys 
785                 790                 795                 800 


Glu Glu Asp Phe Leu His Arg Glu Glu Arg Ile Glu Leu Trp Asp Lys 
                805                 810                 815     


Lys Lys Asp Lys Phe Lys Gly Tyr Lys Ala Lys Lys Lys Phe Lys Glu 
            820                 825                 830         


Met Thr Asp Lys Glu Lys Glu Glu His Arg Ser Tyr Leu Glu Phe Gln 
        835                 840                 845             


Ser Trp Asn Lys Phe Glu Arg Glu Leu Arg Leu Val Arg Asn Gln Asp 
    850                 855                 860                 


Ile Val Thr Trp Leu Leu Cys Thr Glu Leu Ile Asn Lys Leu Lys Ile 
865                 870                 875                 880 


Asp Glu Leu Asn Ile Lys Glu Leu Lys Lys Leu Arg Leu Lys Asp Ile 
                885                 890                 895     


Asn Thr Asp Thr Ala Lys Glu Glu Lys Asn Asn Ile Leu Asn Arg Val 
            900                 905                 910         


Met Pro Met Glu Leu Pro Val Thr Val Tyr Glu Val Asn Lys Gly Gly 
        915                 920                 925             


Tyr Ile Ile Lys Asn Lys Pro Leu His Thr Ile Tyr Ile Lys Glu Ala 
    930                 935                 940                 


Lys Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys Asp 
945                 950                 955                 960 


Arg Arg Leu Asn Gly Leu Phe Ser Phe Val Lys Thr Pro Ser Glu Ala 
                965                 970                 975     


Glu Ser Glu Ser Asn Pro Ile Ser Lys Ser Arg Val Glu Ser Glu Leu 
            980                 985                 990         


Gly Lys Tyr Gln Asn Ala Arg Leu  Asn Ile Ile Glu Asp  Met Leu Ala 
        995                 1000                 1005             


Leu Glu  Lys Thr Leu Ile Asp  Lys Tyr Asn Ser Leu  Asp Thr Asp 
    1010                 1015                 1020             


Asn Phe  His Asn Met Leu Thr  Gly Trp Leu Lys Leu  Lys Gly Lys 
    1025                 1030                 1035             


Ala Asn  Lys Ala Arg Phe Gln  Asn Glu Val Asp Leu  Leu Val Ala 
    1040                 1045                 1050             


Val Arg  Asn Ala Phe Ser His  Asn Gln Tyr Pro Met  Tyr Asn Glu 
    1055                 1060                 1065             


Asn Leu  Phe Gly Asn Ile Glu  Arg Phe Ser Leu Ser  Ser Ser Asn 
    1070                 1075                 1080             


Ile Ile  Glu Ser Lys Gly Leu  Asp Ile Ala Val Lys  Leu Lys Glu 
    1085                 1090                 1095             


Glu Val  Ser Lys Ala Ala Lys  Lys Ile Gln Asn Glu  Glu Asp Asn 
    1100                 1105                 1110             


Lys Lys  Glu Lys Glu Thr 
    1115                 


<210>  2641
<211>  994
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2641

Met Asp Ser Lys Tyr Ile Leu Gly Ser Tyr Leu Asn Met Ala Asn Asp 
1               5                   10                  15      


Asn Phe Ile Asn Thr Ile His Leu Leu Ala Lys Lys Leu Lys Thr Pro 
            20                  25                  30          


Lys Gly Glu Asp Gln Asn Leu Asp Gln Val Val Ser Tyr Ile Thr Arg 
        35                  40                  45              


Ile Phe Asp Asn Ser Asn Gln Val Pro Glu Thr Glu Gln Ile Val Glu 
    50                  55                  60                  


Phe Tyr Phe Pro Trp Leu Glu Ala Leu Lys Asn Ala Asn Gly Phe Gly 
65                  70                  75                  80  


Lys Ser Glu Leu Pro Glu Leu Lys Ile Phe Tyr Lys Asp Val Leu Cys 
                85                  90                  95      


Ser Phe Ala Glu Asn Leu Lys Asp Leu Arg Asn Asn Tyr Thr His Tyr 
            100                 105                 110         


Ile His Lys Thr Ile Ser Tyr His Pro Ile Ile Tyr Lys Lys Glu Gly 
        115                 120                 125             


Asn Thr Leu Gln Ser Ser Leu Pro Lys Ala Leu Leu Gln Ile Tyr Asp 
    130                 135                 140                 


Ala Ser Ile Lys Leu Ala Lys Glu Arg Phe Ser Ala Asp Glu Asn Ala 
145                 150                 155                 160 


Val Thr His Leu Arg Arg Tyr Lys Met Val Gly Lys Lys Val Val Arg 
                165                 170                 175     


Lys Thr Glu Ala Asp His Phe Leu Tyr Leu Leu Glu Lys Asp His Leu 
            180                 185                 190         


Leu Thr Glu Lys Gly Ile Ala Phe Phe Thr Ser Leu Phe Leu Asn Arg 
        195                 200                 205             


Lys Tyr Gly Tyr Leu Met Leu Lys Gln Leu Lys Gly Phe Lys Gln Gly 
    210                 215                 220                 


Gly Thr Leu Ala Tyr Arg Leu Thr Leu Glu Thr Phe Leu Ala Tyr Ser 
225                 230                 235                 240 


Asn Ile Lys Pro Val Glu Arg Leu Lys Ala Asp Lys Tyr Ser Asp Val 
                245                 250                 255     


Ala Phe Ile Met Asp Leu Leu Gly Glu Ile Ser Lys Ile Pro Lys Glu 
            260                 265                 270         


Leu Tyr His Ile Leu Pro Glu Thr Tyr Ile Leu Gln Tyr Lys Asn Lys 
        275                 280                 285             


Leu His Ile Glu Leu Asn Glu Asp Ile Ser Leu Glu Ala Tyr Cys Ser 
    290                 295                 300                 


Arg Gly Arg Asn Arg Phe Asp Gln Leu Ala Leu Thr Tyr Leu Asp Arg 
305                 310                 315                 320 


Leu Glu Asp Phe Lys Gln Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr 
                325                 330                 335     


Ile His Asn Gly Tyr Met Lys Val Arg Ile Asp Gly Thr Glu Gln Glu 
            340                 345                 350         


Arg Tyr Leu Ser Glu Lys Met Tyr Gly Cys Cys Lys Asn Ile Tyr Arg 
        355                 360                 365             


Asp Leu Ser Ala Ile Val Ala Lys Gln Tyr Asn Ile Lys Val Lys Asp 
    370                 375                 380                 


Ser Thr Glu Thr Ser Tyr Met Leu Pro Asn Asp Phe Gln Pro His Val 
385                 390                 395                 400 


Ile Arg Ala Tyr Pro His Tyr Val Ile Asn Asn Asn Asn Ile Gly Ile 
                405                 410                 415     


Arg Leu Leu Asp Glu Gly Glu Ser Gly Phe Pro Ile Leu Glu Asn Arg 
            420                 425                 430         


Gly Thr Lys Asn Val Val Pro His Phe Trp Met Ser Lys Tyr Asp Leu 
        435                 440                 445             


Pro Ala Leu Leu Phe Tyr Ala Tyr Leu Arg Ser Asp Ser Arg Phe Ala 
    450                 455                 460                 


Ser Lys Cys Lys Lys Thr Ile Asp Glu Ile Leu Arg Gly Tyr Leu Ser 
465                 470                 475                 480 


Lys Ser Lys Asp Lys Lys Pro Lys Gln Ala Glu Lys Val Ser Val Leu 
                485                 490                 495     


Met Leu Arg Arg Ile Asp Lys Ala Ile Ile Trp Thr Gln Thr Lys Leu 
            500                 505                 510         


Asn Glu Ala Glu Lys Gln Arg Asp Asn Lys Lys Ser Phe Lys Ile Gly 
        515                 520                 525             


Glu Lys Ala Asp Ile Leu Ala His Asp Met Leu Trp Leu Gln Pro Ala 
    530                 535                 540                 


Lys Glu Ser Lys Asp Lys Val Ser Gly Ala Asn Phe Arg Ala Leu Gln 
545                 550                 555                 560 


Thr Ser Leu Ala Phe Phe Lys Arg Asn Glu Leu Glu Asp Ile Phe Lys 
                565                 570                 575     


Lys Ser Phe Leu Ile Gly Gly Asn Asn Pro His Pro Phe Leu Ser Arg 
            580                 585                 590         


Ile Lys Ile Asn Thr Met Pro Ser Leu Phe Asp Phe Tyr Leu Ala Tyr 
        595                 600                 605             


Met Arg Glu Arg Leu Asn Tyr Trp Glu Lys Ile Lys Leu Lys Leu Leu 
    610                 615                 620                 


Lys Gly His Ile Asn Val Ser Cys His Pro Leu Arg Lys Leu Asn His 
625                 630                 635                 640 


Gly Lys Pro Val Asp Gln Asp Asn Lys Lys Asp Glu Gln Pro Ile Phe 
                645                 650                 655     


Leu Pro Arg Gly Ile Phe Asn Asp Val Ile Lys Asn Cys Leu Gln Lys 
            660                 665                 670         


Thr Lys Leu Gly Ile Tyr Leu Lys Asp Gln Gly Val Glu Thr Arg Ser 
        675                 680                 685             


Trp Asn Val Ala Tyr Gln Ile Leu Lys Phe His Glu Ile Ile Asn Asp 
    690                 695                 700                 


Asp Asp Ile Gln Glu Phe Tyr Lys Gln Pro Arg Lys Tyr Ala Ile Leu 
705                 710                 715                 720 


Asp Glu Asn His Tyr Leu Thr Leu Glu Glu Arg Thr Asp Arg Leu Lys 
                725                 730                 735     


Asp Leu Lys Pro Glu Cys Ile Glu Val Ser Lys Ala Asn Asp Ile Leu 
            740                 745                 750         


Glu Lys Glu Asp Tyr Leu Leu Arg Lys Ser Tyr Asn Gln Val Cys Asp 
        755                 760                 765             


Asn Glu Ser Ala Ile Arg Leu Tyr Gln Val Gln Asp Ile Leu Leu Phe 
    770                 775                 780                 


Met Ile Ala Gln Arg Leu Cys Asn Glu Ile Ile Leu Gly Asp Lys Gln 
785                 790                 795                 800 


Glu Lys Lys Glu Lys Val Glu Thr Ser Phe Ser Leu Thr Leu Lys Asn 
                805                 810                 815     


Leu Ser Lys Lys Phe Asp Gln Pro Val His Phe Glu Ile Lys Met Asn 
            820                 825                 830         


Asn Val Asn Leu Phe Ser Asp Thr Asp Ile Pro Val Lys Asn Phe Gly 
        835                 840                 845             


Lys Met Leu Arg Leu Lys Lys Asp Ala Arg Phe Ile Ser Tyr Asp Lys 
    850                 855                 860                 


Leu Phe Lys Gly Gln Lys Gln Asn Ile Asn Tyr Asn Asp Tyr Cys Lys 
865                 870                 875                 880 


Glu Glu Glu Tyr Phe Asp Ile Cys Arg Ile Gln Met Val Lys Leu Cys 
                885                 890                 895     


His Glu Leu Glu Glu Lys Leu Leu Glu Glu Gly Ile Ile Thr Glu Ser 
            900                 905                 910         


Pro Asn Ser Gly Tyr Tyr Pro Phe Ala Asp Leu Val Gln Ile Ile Ile 
        915                 920                 925             


Asn Gln Gly Val Val Ile Ser Ser Ser Asp Val Lys Phe Ile Leu Glu 
    930                 935                 940                 


Ala Arg Asn Met Phe Leu His Asn Glu Tyr Lys Gln Cys Cys Val Asn 
945                 950                 955                 960 


Ser Ile Asn Ser Ile Asp Ser Phe Ile Ala Glu Lys Val His Asn Leu 
                965                 970                 975     


Phe Lys Gln Lys Met Asp Asn Ile Leu Gly Gln Leu Glu Ser Ile Lys 
            980                 985                 990         


Ser Ser 
        


<210>  2642
<211>  1123
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2642

Met Ile Thr Glu Gln Ala Lys Val Glu Glu Ser Thr Lys Ser Val Tyr 
1               5                   10                  15      


Gln Asn Pro Gly Tyr Phe Gly Ala Phe Leu Asn Met Ala Val Leu Asn 
            20                  25                  30          


Val Phe Ala Ile Ser Asn Gln Ile Val Lys Thr Phe Lys Glu Leu Asn 
        35                  40                  45              


Gly Val Glu Leu Lys Asn Asp Ser Asp Ile Lys Cys Ser Asp Lys Asn 
    50                  55                  60                  


Leu Leu Leu Gln Ile Phe Asn Asn Ala Asn Leu Pro Ser Glu Ile Lys 
65                  70                  75                  80  


Trp Asn Val Phe Asn Tyr Leu Tyr Lys Arg Gln His Phe Pro Val Leu 
                85                  90                  95      


Lys Tyr Phe Leu Ser Cys Tyr His Asp Asp Gly Asn Gln Arg Phe Tyr 
            100                 105                 110         


Asn Asn Glu Thr Lys Leu Phe Glu Arg Thr His Gln Phe Leu Gln Glu 
        115                 120                 125             


Ser Phe Asn Ala Leu Val Ala Leu Arg Asn Asp Phe Thr His Tyr Ile 
    130                 135                 140                 


Ala Ile Asp Asp Gln Gly Asn Glu Val Glu Lys Lys Tyr Glu Val His 
145                 150                 155                 160 


Gln Asn Leu Ala Asn Leu Met Gln Asp Glu Leu Leu His Ala Ser Ile 
                165                 170                 175     


Asn Phe Ser Lys Thr Arg Phe Glu Gln Thr Gln Ile Glu Glu Asp Phe 
            180                 185                 190         


Lys Phe Leu Gln His Val Lys Leu Ile Glu Asp Asn Val Pro Lys Leu 
        195                 200                 205             


Thr Glu Gln Gly Leu Tyr Phe Phe Thr Ser Leu Phe Leu Glu Arg Gly 
    210                 215                 220                 


Lys Thr Tyr Leu Phe Leu Lys Lys Leu Thr Gly Phe Lys Asn Glu Thr 
225                 230                 235                 240 


Thr Pro Ser Phe Arg Ala Thr Leu Lys Val Phe Ser Ala Phe Cys Leu 
                245                 250                 255     


Lys Leu Pro Lys Ala Lys Ile Gln Asn Asp Asp Tyr Lys Gln Ser Leu 
            260                 265                 270         


Leu Met Glu Met Leu Pro Glu Leu Ala Lys Cys Pro Ala Ile Leu Tyr 
        275                 280                 285             


Asn Arg Leu Ser Glu Asp Asp Lys Gln Lys Phe Lys Thr Lys Ile Ser 
    290                 295                 300                 


Asn Glu Ala Arg Lys Asn Ile Glu Leu Asn Ser Thr Asp Tyr Lys Asn 
305                 310                 315                 320 


Ile Asp Ile Gln Gln Leu Glu Leu Glu Ile Asn Asp Leu Val Ser Gln 
                325                 330                 335     


Lys Arg Arg Ser Asp Arg Phe His Tyr Phe Ala Leu Arg Phe Leu Asp 
            340                 345                 350         


Glu Leu Asp Val Phe Lys Asn Ile Lys Phe Gln Ile Lys Leu Gly Arg 
        355                 360                 365             


Leu Met Phe Ser Glu Asp Asp Ile Arg Asp Lys Glu Ile Leu Gly Glu 
    370                 375                 380                 


Ile Gln Ala Arg Lys Ile Thr Lys Thr Val Cys Ala Phe Gly Lys Leu 
385                 390                 395                 400 


Ser Glu Leu Glu Lys Met Ala Glu Asn Gln Leu Val Ser Gln Leu Lys 
                405                 410                 415     


Gly His Thr Asn Glu Trp Lys Phe Asp Gln Phe Ala Pro His Tyr Asn 
            420                 425                 430         


Met Gln His Asn Lys Ile Ala Phe Cys Phe Ser Glu Gln Val Lys Tyr 
        435                 440                 445             


Pro Val Leu Lys Lys Glu Asp Glu Lys Ala Asn Gln Pro Asp Gly Tyr 
    450                 455                 460                 


Leu Ser Leu His Ala Leu Pro Lys Leu Ile Leu Thr Ser Ile Leu Glu 
465                 470                 475                 480 


Ser Asp Lys Leu Glu Thr Leu Ile Lys Glu Phe Phe Lys Asn Asn Ser 
                485                 490                 495     


Asp Thr Ile Leu Asn Val Leu Thr Leu Lys Glu Ile Lys Asp Gln Leu 
            500                 505                 510         


Asn Phe Gly Ser Asp Pro Lys Glu Leu Thr Arg Lys Leu Ile Asp Tyr 
        515                 520                 525             


Asn Lys Asn Pro Arg Ile Leu Ser Gly Lys Glu Lys Glu Glu Lys Arg 
    530                 535                 540                 


Asp Leu Ala Glu Arg Met Glu Lys Glu Ile Asn Asp Arg Glu Asp Tyr 
545                 550                 555                 560 


Ala Ile Lys Met Lys Ser Arg Asn Lys Lys Leu Asn Val Ala Leu Gln 
                565                 570                 575     


Asn Tyr Asn Leu His His Asn Gln Leu Pro Ser Ile Val Lys Asp Tyr 
            580                 585                 590         


Leu Leu Asn Ile Gln Asn Pro Ser Leu Ala Leu Lys Ile Asn Thr Tyr 
        595                 600                 605             


Leu Lys Ala Glu Lys Leu Thr Phe Gln Gln Ser Leu Lys Lys Ile Lys 
    610                 615                 620                 


Lys Gln Gln Glu Leu Asn His Thr Ile Lys Leu Gly Glu Leu Ala Thr 
625                 630                 635                 640 


Ile Ile Thr Arg Asp Met Met Asn Met Leu Val Asp Thr Ala Leu Lys 
                645                 650                 655     


Ser Lys Leu Thr Pro Pro Tyr Thr Asn Lys Ile Gln Asn Ala Ile Ala 
            660                 665                 670         


His Phe Gly Leu Lys Lys Asn Glu Leu Ile Asn Met Leu Thr Glu Trp 
        675                 680                 685             


Lys Ile Leu Asp Asn Arg Ala Gly His Val Phe Leu Gln Lys Asn His 
    690                 695                 700                 


Ile Lys Asn Ser Lys Gly Val Val Asp Phe Tyr Glu Asn Tyr Val Glu 
705                 710                 715                 720 


Gln Lys Ile Lys Tyr Ile Asp Asn Ile Lys Ala Lys Thr Lys Asn Leu 
                725                 730                 735     


Phe Gly Leu Lys Pro Asp Ala Asn Val Ser Asn Gln Leu Pro Tyr Lys 
            740                 745                 750         


Tyr Arg Lys Leu Thr Glu Lys Tyr Gln Lys Pro Ala Ile Lys Asp Tyr 
        755                 760                 765             


Val Lys Gln Lys Gln Lys Val Pro Val Asn Leu Pro Leu Asn Leu Phe 
    770                 775                 780                 


Asp Glu Val Leu Phe Ser Ala Leu Arg Ser Lys Val Asn Thr Ser Lys 
785                 790                 795                 800 


Thr Gly Leu Asn Asn Leu Leu Ala Ala Tyr Leu Lys Asp Asp Ser Gln 
                805                 810                 815     


Thr Phe Tyr Ser Phe Asn Arg Leu Tyr Asn Ile Asn Lys Glu Pro Thr 
            820                 825                 830         


Thr Val Asp Val Asn Ser Lys Ser Leu Lys Glu Ile Lys Ile Glu Phe 
        835                 840                 845             


Gly Lys Pro Val Phe Glu Asn Glu Lys Lys Ile Arg Tyr Gln Gln Met 
    850                 855                 860                 


Ile Asp Arg Val Met Lys Met Met Cys Ile Glu Leu Met Gln Lys Gln 
865                 870                 875                 880 


Asp Thr Asp Leu Thr Leu Gly Val Ser Gln Leu Glu Leu Ala Lys Leu 
                885                 890                 895     


Ser Asn Ala Thr Pro Asp Lys Asn Phe Leu Asn Ala Pro Val Ser Phe 
            900                 905                 910         


Lys Arg Thr Val Asn Ala Asp Lys Glu Leu Ile Ala Glu Asp Asn Glu 
        915                 920                 925             


Glu Thr Lys Gln Lys Val Ala Glu Ser Ile Arg Ala Tyr Lys Ala Gly 
    930                 935                 940                 


Thr Lys Glu Val Ile Glu His Trp Tyr Ser Trp Thr Val Lys Asp Tyr 
945                 950                 955                 960 


Gly Arg Phe Thr Arg Leu Leu Val Asp Arg Arg Leu Glu Asn Leu Leu 
                965                 970                 975     


Lys His Phe Glu Gly Asp Ala Ile Pro Phe Ser Ile Ile Lys Tyr Glu 
            980                 985                 990         


Leu Asp Asn Tyr Asp Lys Tyr Trp  His Lys Ile Leu Asp  Glu Leu Leu 
        995                 1000                 1005             


Lys Val  Glu Lys Ala Ile Phe  Glu Lys Asp Gly Glu  Arg Ile Lys 
    1010                 1015                 1020             


Ala Leu  Gln Leu Gly Ser Lys  Tyr Glu His Val Gln  Phe Gly Lys 
    1025                 1030                 1035             


Tyr Val  Lys Trp Leu Lys Glu  Lys Ser Ile Asn Tyr  Asp Lys Lys 
    1040                 1045                 1050             


Leu Phe  Leu Asn Val Arg Asn  Lys Phe Ser His Ser  Gln Phe Leu 
    1055                 1060                 1065             


Glu Ile  Asp Lys Val Gly Leu  Ser Lys Ile Ser Glu  Gln Ile Thr 
    1070                 1075                 1080             


Tyr Asn  Phe Asn Glu Asn Tyr  Leu Thr Gly Asp Trp  Ile Asn Thr 
    1085                 1090                 1095             


Asn Tyr  Glu Ser Ile Ala Ser  Lys Val Tyr Thr Lys  Phe Lys Thr 
    1100                 1105                 1110             


Glu Ile  Asp Glu Ile Leu Lys  Gln Ile Ala 
    1115                 1120             


<210>  2643
<211>  1081
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2643

Met Lys Lys Thr Asn Thr Tyr Phe Asp Phe Lys Asp Lys Thr Gln Lys 
1               5                   10                  15      


Tyr Phe Phe Ala Gly Leu Phe Asn Thr Ala Leu Asn Asn Phe Asp Leu 
            20                  25                  30          


Ser Leu Asp Glu Leu Ala Asn Arg Thr Gly Leu Lys Cys Asn Gly Lys 
        35                  40                  45              


Glu Leu Ile Ala Val Ala Phe Asn Asp Thr Cys Ser Gln Thr Asp Tyr 
    50                  55                  60                  


Asn Asn Arg Leu Ser Tyr Leu Ser Glu Ser Leu Ala Phe Ile Glu Leu 
65                  70                  75                  80  


Ile Lys Thr Lys Glu Arg Ser Tyr Ile Arg Leu His Leu Thr Glu Leu 
                85                  90                  95      


Tyr Asn Leu Ile Asp Asn Tyr Arg Asn Tyr Phe Thr His Leu Glu His 
            100                 105                 110         


Pro Gly Leu Ile Ile Lys Pro Leu Ile Phe Lys Leu Leu Asp Leu Phe 
        115                 120                 125             


Ile Leu Glu Ser Ala Arg Thr Val Ile Lys Glu Arg Val Lys Thr Glu 
    130                 135                 140                 


Glu Asn Lys Ser Tyr Leu Ser Lys Lys Phe Lys Leu Glu Ile Thr Ser 
145                 150                 155                 160 


Thr Phe Glu Ala Ala Asn Asn Ala Ile Asn Leu Glu Asn Lys Asn Asn 
                165                 170                 175     


Pro His Ser Lys Thr His Lys Lys Leu Ile Thr Gln Asn Asp Lys Ile 
            180                 185                 190         


Asn Phe Val Leu Ile Asn Ala Phe Tyr Asn Phe Leu Ile Asn Thr Asp 
        195                 200                 205             


Glu Ile Pro Thr Leu Lys Glu Thr Ala Arg Ser Ile Asn Lys Asp Thr 
    210                 215                 220                 


Gly Gln Ile Ser Gln Asn Gly Ile Ile Gln Leu Leu Ala Ile Phe Leu 
225                 230                 235                 240 


Asn Lys Lys Gln Leu Glu Ile Leu Phe Asp Asn Thr His Tyr Leu Lys 
                245                 250                 255     


Gly Thr Leu Lys Leu Asn His Leu Cys Thr Arg Trp Thr Tyr Ser Gln 
            260                 265                 270         


Leu Ala Tyr Arg Asn Ile Lys Lys Leu Leu Lys Ser Asp Tyr Ser Asn 
        275                 280                 285             


Asp Ser Leu Ile Leu Gln Met Leu Ser Glu Leu Thr Lys Cys Pro Lys 
    290                 295                 300                 


His Leu Tyr Pro Asn Leu Pro Asn Asn Ser Lys Gln Glu Phe Ile Glu 
305                 310                 315                 320 


Asp Leu Asn Glu Tyr Leu Lys Glu Thr Glu Tyr Phe Lys Asp Ser Ile 
                325                 330                 335     


Ala Gln Glu Thr Val Ser Asn Glu Val Ile Arg Lys Arg Tyr Glu Asp 
            340                 345                 350         


Lys Phe Pro Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe Ile Asp Phe 
        355                 360                 365             


Pro Asn Leu Arg Phe Gln Ile Asn Leu Gly Lys Phe Asn His Asn Thr 
    370                 375                 380                 


Cys Leu Lys Lys Phe Glu Asn Thr Ala Val Tyr Thr Glu Arg Gln Ile 
385                 390                 395                 400 


Leu Glu Lys Leu Thr Ile Phe Glu Lys Leu Thr Leu Ala Thr Asn Lys 
                405                 410                 415     


Lys Thr Glu Tyr Phe Leu Asn Asn Asn Leu Pro Asp Ser Glu Gly Trp 
            420                 425                 430         


Gln Glu Tyr Pro Lys Pro Ser Tyr Gln Phe Tyr Asn Asn Asn Ile Gly 
        435                 440                 445             


Phe Trp Leu Gly Ile Lys Asn Gly Ala Val Thr Asp Ala Lys Glu Lys 
    450                 455                 460                 


Arg Glu Asn Asp Lys Ser Ser Lys Phe Asp Ile Leu Lys Lys Ile Gly 
465                 470                 475                 480 


Leu Glu Cys Cys Leu Lys Lys Pro Val Ala Tyr Leu Ser Phe Asn Glu 
                485                 490                 495     


Leu Pro Ala Leu Leu Tyr Thr Val Leu Ile Glu Lys Lys Thr Ala Lys 
            500                 505                 510         


Glu Val Glu Arg Ile Phe Leu Lys Lys Ile Gly Glu Gln Thr Gly Ala 
        515                 520                 525             


Ile Asn Lys Phe Ala Asp Ile Asn Asn Phe Glu Lys Lys Ile Ile Pro 
    530                 535                 540                 


His Lys Phe Lys Glu Ile Leu Glu Asn Lys Glu Ser Asn Val Lys Trp 
545                 550                 555                 560 


Glu Lys Leu Lys Lys Asp Ile Glu Lys Glu Met Leu Ile Ser Pro Leu 
                565                 570                 575     


Asp Glu Ile Arg Ile His Tyr Lys Thr Ala Ser Lys His Pro Asn Asp 
            580                 585                 590         


Leu Ser Phe Ser Glu Lys Gly Lys Ile Ala Thr Trp Leu Ala His Asp 
        595                 600                 605             


Ile Lys Arg Phe Val Lys Ala Glu Thr Lys Lys Asp Trp Lys Gly Tyr 
    610                 615                 620                 


Gln Phe Ser Glu Phe Gln Ser Leu Leu Ala Tyr Tyr Asp Leu Lys Lys 
625                 630                 635                 640 


Met Glu Leu Leu Asn Phe Val Asn Phe Val Leu Lys Ile Asn Ile Lys 
                645                 650                 655     


Gln Asp Ile Val Phe Glu Gly Ile Asp Phe Asn Gln Lys Thr Leu Tyr 
            660                 665                 670         


Asp Phe Tyr Lys Asn Tyr Leu Ser Asn Arg Lys Lys Phe Leu Glu Gly 
        675                 680                 685             


Asn Leu Tyr Ser Ile Asp Gln Lys Asp Glu Val Pro Ala Lys Leu Trp 
    690                 695                 700                 


Arg Lys Arg Glu Leu Ser Ile Phe Thr Gly Phe Asp Asp Lys Leu Tyr 
705                 710                 715                 720 


Lys Tyr Lys Asn Phe Lys Thr Tyr Lys Glu Asn Leu Met Asn Met Pro 
                725                 730                 735     


Leu Asn Leu Pro Arg Gly Ile Phe Ser Asp Lys Gln Thr Cys Tyr Asn 
            740                 745                 750         


Lys Asn Ser Gln Asn Asn Asn Glu Leu Ala Glu Trp Phe Thr Lys Ser 
        755                 760                 765             


Asn Asn Ile Asn Asp Phe Gln Lys Phe Tyr Ser Phe Thr Arg Phe Tyr 
    770                 775                 780                 


Glu Asn Cys Gln Leu Thr Leu Asn Pro Leu Lys Gly Leu Lys Glu Gln 
785                 790                 795                 800 


Asn Asn Asn Lys Gly Val Pro Lys Glu Val Tyr Lys Asn Glu Lys Asn 
                805                 810                 815     


Ile Arg Asn Thr Met Arg Gln Asp Phe Tyr Ile Phe Glu Met Val Lys 
            820                 825                 830         


Tyr Tyr Phe Lys Ile Asn Glu Ser Leu Lys Ser Asp Leu Asn Asp Leu 
        835                 840                 845             


Lys Leu Asn Thr Leu Phe Leu Thr Lys Gln Glu Lys Glu Asn Asn Leu 
    850                 855                 860                 


Lys Val Leu Asn Gln Gln His Ser Arg Ser Lys Gly Asp Lys Ser Glu 
865                 870                 875                 880 


Asn Ile Leu Asn Glu Asn Tyr Ile Leu Ser Lys His Ile Met Met Ser 
                885                 890                 895     


Ile Leu Glu Gly Lys Ile Gln Gly Met Val Ala Leu Lys Ser Val Gly 
            900                 905                 910         


Lys Tyr Arg Phe Leu Ser Gln Asp Lys Arg Val Lys Gln Leu Val Thr 
        915                 920                 925             


Tyr Ile Pro Asp Lys Ile Trp Ser Phe Glu Glu Ile Asn Ser Glu Ile 
    930                 935                 940                 


Asp Glu Tyr Asp Lys Ile Arg Ala Phe Ser Phe Phe Lys Ile Ile His 
945                 950                 955                 960 


Glu Ile Glu Glu Lys Ile Phe Asn Lys Ala Ile Asn Asn Lys Glu Glu 
                965                 970                 975     


Ser Tyr Leu Leu Val Asp Gly His Pro Asn Phe Lys Ala Tyr Ile Ile 
            980                 985                 990         


Tyr Tyr Phe Leu Lys Thr Gln Asp  Glu Lys Asp Phe Phe  Asn Lys Leu 
        995                 1000                 1005             


Asp Val  Lys Asn Val Asn Ile  Asn Asp Ile Ala Ile  Ser Lys Phe 
    1010                 1015                 1020             


Lys Leu  Leu Phe Leu Ile Ile  Lys Ile Arg Asn Lys  Ile Cys His 
    1025                 1030                 1035             


Asn Gln  Leu Ile Ser Ser Asp  Glu Phe Asn Phe Leu  Leu Glu Phe 
    1040                 1045                 1050             


Thr Pro  Ile Glu Pro Asp Glu  Leu Tyr Met Ser Tyr  Leu Leu Lys 
    1055                 1060                 1065             


Ala Tyr  Lys Lys Ile Val Asn  Ile Ser Trp Asn Leu  Val 
    1070                 1075                 1080     


<210>  2644
<211>  1119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2644

Met Asp Thr Ile Glu Arg Ile Glu Ile Lys Ser Ala Asn Val Tyr Lys 
1               5                   10                  15      


Thr Leu Glu Asn Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala 
            20                  25                  30          


Arg Leu Asn Ile Phe Ser Ile Asn Asn Ser Val Ala Asp Lys Ile Lys 
        35                  40                  45              


Val Ala Pro Ile Pro Asn Glu Glu Lys Ile Leu Asp Ser Phe Leu Cys 
    50                  55                  60                  


Asn His Asn Arg Lys His Leu Asn Trp Asn Leu Ala His Ala Ile Ala 
65                  70                  75                  80  


Val Lys Phe Leu Pro Ile Ile Lys Val Phe Asn Phe Glu Gly Leu Pro 
                85                  90                  95      


Lys Ser Glu Arg Thr Ser Asp Phe Asn Asn Ile Asn Thr Gly Lys Asp 
            100                 105                 110         


Phe Ala Ala Met Ala Asp Ala Leu Arg Ser Leu Phe Gly Glu Ile Gln 
        115                 120                 125             


Glu Phe Arg Asn Asp Tyr Ser His Tyr Tyr Ser Ile Ala Asn Gly Asn 
    130                 135                 140                 


Lys Arg Lys Thr Thr Ile Ser Lys Glu Val Ala Glu Phe Leu Thr Lys 
145                 150                 155                 160 


Asn Phe Ala Arg Ala Ile Glu Tyr Thr Lys Glu Arg Phe Asn Gly Val 
                165                 170                 175     


Leu Asn Asn Glu Asp Phe Tyr His Val Lys Glu Arg Val Leu Val Asn 
            180                 185                 190         


Gln Asp Asn Thr Ile Ser Thr Asp Gly Phe Val Phe Leu Ile Ala Met 
        195                 200                 205             


Phe Leu Glu Arg Glu His Ala Phe Gln Phe Ile Gly Lys Ile Lys Gly 
    210                 215                 220                 


Leu Lys Gly Thr Gln His Asn Ser Phe Ile Ala Thr Arg Glu Val Leu 
225                 230                 235                 240 


Met Ala Phe Cys Ala Lys Leu Pro His Asp Arg Phe Val Ser Glu Asp 
                245                 250                 255     


Lys Lys Gln Ala Phe Thr Leu Asp Ile Ile Ser Thr Leu Asn Arg Cys 
            260                 265                 270         


Pro Lys Glu Leu Tyr Ala Val Ile Thr Glu Glu Glu Arg Lys Ala Phe 
        275                 280                 285             


Lys Pro Asn Leu Asp Ser Leu Lys Ile Glu Asn Leu Leu Asp Asn Ser 
    290                 295                 300                 


Thr Asn Asp Lys Ala Asp Ile Glu Asn Tyr Asp Lys Tyr Ile Glu Ala 
305                 310                 315                 320 


Leu Thr Arg Lys Ile Arg His Ser Asn Arg Phe Ser Tyr Phe Ala Leu 
                325                 330                 335     


Lys Phe Ile Asp Glu Thr Asn Ile Phe Lys Gln Leu Arg Phe Gln Ile 
            340                 345                 350         


Asn Leu Gly Lys Leu Glu Leu Asp Glu Tyr Glu Lys Pro Ile Asn Asn 
        355                 360                 365             


Glu Leu Tyr Pro Arg Ser Ile Val Gln Asp Val Lys Ala Phe Gly Lys 
    370                 375                 380                 


Leu Ser Asp Phe Glu Asp Glu Lys Glu Val Leu Lys Gln Ile Asp Lys 
385                 390                 395                 400 


Glu Gly Asn Ser Leu Gly Phe Asp Gln Tyr Ala Pro Phe Tyr Asn Thr 
                405                 410                 415     


Lys Ser Asn Lys Ile Gly Leu His Thr Asn Asn Ala Lys Ser Ile Val 
            420                 425                 430         


Ile Asn Lys Pro Lys Ser Glu Ser Lys Ile Lys Asn Lys Leu Lys Lys 
        435                 440                 445             


Ala Leu Pro Glu Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile 
    450                 455                 460                 


Val Leu Glu Tyr Leu Glu Lys Gly Lys Ser Glu Glu Leu Ile Asn Asp 
465                 470                 475                 480 


Phe Ile Leu Ala Ser Asn Ser Lys Ile Thr Asn Lys Gln Phe Ile Asp 
                485                 490                 495     


Glu Val Lys Gly Lys Leu Pro Asn Asp Trp Asn Glu Phe Asn Lys Arg 
            500                 505                 510         


Ser Asp Ser Lys Lys Glu Thr Ala Tyr Lys Pro Asn Ala Leu Ala Tyr 
        515                 520                 525             


Leu Arg Asn Arg Lys Lys Ile Leu Asp Glu Val Leu Ala Gln Tyr Asn 
    530                 535                 540                 


Leu Asn His Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp Leu Ser 
545                 550                 555                 560 


Val Val Asp Ile Asn Ser Glu Arg Ala Ile Ser Asp Arg Ile Lys Arg 
                565                 570                 575     


Met Lys Arg Glu Gly Met Asp Arg Leu Lys Ser Tyr Gln Lys Tyr Lys 
            580                 585                 590         


Lys Thr Arg Lys Gly Arg Ile Pro Lys Ile Gly Glu Met Ala Thr Phe 
        595                 600                 605             


Leu Ala Lys Asp Ile Ile Asp Met Ile Ile Ser Thr Asp Lys Lys Lys 
    610                 615                 620                 


Lys Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu 
625                 630                 635                 640 


Phe Ala Asp Pro Asp Lys Lys Ala Leu Phe Ile Asp Ile Ile Ser Lys 
                645                 650                 655     


Glu Leu His Leu Asn Glu Leu Asp Gly His Pro Phe Leu Lys Tyr Ile 
            660                 665                 670         


Gln Phe Gly Lys Ile Ser Tyr Thr Gln Asp Leu Tyr Glu Ser Tyr Leu 
        675                 680                 685             


Gln Glu Lys Val Asn Lys Met Leu Asp Val Lys Asn His Arg Thr Gly 
    690                 695                 700                 


Lys Thr Ser Gln Ile Asp Lys Ser Trp Met Met Thr Thr Phe Tyr Lys 
705                 710                 715                 720 


Lys Glu Trp Asn Glu Glu Val Gly Lys Gln Leu Thr Glu Val Lys Leu 
                725                 730                 735     


Pro His Asn Leu Ser Tyr Ile Pro Phe Ser Leu Arg Gln Leu Lys Glu 
            740                 745                 750         


Lys Thr Ser Tyr Ser Leu Asp His Trp Leu His Asn Ile Thr Lys Gly 
        755                 760                 765             


Lys Glu Val Asn Asp Gly Lys Lys Pro Ile Asn Leu Pro Thr Asn Leu 
    770                 775                 780                 


Phe Asp Glu Thr Leu Ile Arg Leu Leu Lys Ser Asp Leu Asp Thr Gln 
785                 790                 795                 800 


His Glu Gln Tyr Pro Glu Asp Ala Lys Tyr Asn Glu Leu Phe Lys Ile 
                805                 810                 815     


Trp Trp Arg Lys Arg Gly Asp Ser Thr Gln Ser Phe Tyr Asn Ala Glu 
            820                 825                 830         


Arg Glu Tyr Leu Ile Tyr Asp Glu Lys Val Asn Phe Lys Leu Gln Glu 
        835                 840                 845             


Asn Ala Lys Phe Ala Asp Phe Tyr Ser Asp Asn Leu Arg Lys Ala Tyr 
    850                 855                 860                 


Lys Ala Lys Gln Ala Ala Arg Arg Ile Glu Lys Arg Thr Asn Arg Arg 
865                 870                 875                 880 


Leu Pro Asp Val Gln Phe Ser Asp Val Glu Lys Val Phe Lys Arg Thr 
                885                 890                 895     


Ile Ser Asn Thr Glu Lys Gln Ile Arg Leu Leu Lys Glu Glu Asp Gln 
            900                 905                 910         


Ile Met Leu Leu Met Leu Glu Lys Leu Met Thr Ser Asp Gln Asp Leu 
        915                 920                 925             


Asn Leu Lys Leu Ser Gln Ile Asp Thr Leu Leu Asn Asp Thr Ile Thr 
    930                 935                 940                 


Val Lys Lys Ser Val Ser Gly Gln Leu Ser Phe Asp Asn Asn Ala Glu 
945                 950                 955                 960 


Ile Thr Lys Ile Ile Ile Asp Gln Arg Lys Arg Lys Asp Phe Ser Met 
                965                 970                 975     


Leu His Lys Tyr Ser Phe Asp Arg Arg Leu Pro Glu Leu Phe Glu Tyr 
            980                 985                 990         


Phe Lys Glu Ser Glu Ile Pro Leu  His Asp Leu Lys Asn  Glu Leu Glu 
        995                 1000                 1005             


Ala Tyr  Asn Asn Ala Lys Gln  Met Val Leu Asp Ala  Ala Phe Asn 
    1010                 1015                 1020             


Leu Glu  Lys Ala Val Ile Thr  Asn Asn Asn Ala Glu  Asp Leu Ile 
    1025                 1030                 1035             


Asp Pro  Asp Tyr Arg Asn Gly  His Ile Gln His Lys  Leu Tyr Leu 
    1040                 1045                 1050             


Gln Trp  Leu Lys Lys Glu Gly  Lys Ile Asn Glu Asn  Glu Phe Ser 
    1055                 1060                 1065             


Phe Leu  Asn Met Val Arg Asn  Ser Phe Ser His Asn  Gln Tyr Pro 
    1070                 1075                 1080             


Gln Lys  Thr Thr Met Ser Leu  Phe Val Asn Gln Trp  Ala Asp Asn 
    1085                 1090                 1095             


Asn Phe  Ala Leu Gln Ile Ala  Glu Ile Tyr Asn Val  Lys Ile Asp 
    1100                 1105                 1110             


Ser Thr  Ile Ala Lys Tyr 
    1115                 


<210>  2645
<211>  1067
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2645

Met Lys Asp Lys Pro Leu Ile Lys Ser Lys Arg Thr Leu Ser Asp Asp 
1               5                   10                  15      


Pro Gln Tyr Phe Gly Ser Tyr Leu Asn Ile Ala Arg His Asn Val Phe 
            20                  25                  30          


Leu Ile Cys Asn His Leu Ala Glu Lys Phe Lys Glu Lys Leu Leu Lys 
        35                  40                  45              


Asp Asp Glu Lys Ile His Asp Ser Phe Leu Cys Thr Lys Ala Lys Asp 
    50                  55                  60                  


Leu Tyr Val Phe Thr Gln Leu Ile Arg Phe Leu Pro Ile Ala Lys Val 
65                  70                  75                  80  


Phe Asp Pro Glu Met Trp Pro Lys Asp Glu Arg Val Ser Glu Ser Val 
                85                  90                  95      


Asn Leu Asp Asp Leu Pro Lys Ile Met Lys Ala Cys Phe Asn Asp Leu 
            100                 105                 110         


Asn Gly Phe Arg Asn Asp Tyr Thr His Tyr Tyr Ser Val Ala Thr Glu 
        115                 120                 125             


Thr Glu Arg Lys Thr Glu Val Asn Glu Asp Val Ala Gln Phe Ile Arg 
    130                 135                 140                 


Glu Asn Phe Gln Arg Ala Ile Ser Tyr Thr Leu Asn Arg Phe Lys Asp 
145                 150                 155                 160 


Thr Phe Thr Asp Ala Asp Ile Glu Lys Val Arg Leu Tyr Pro Leu Phe 
                165                 170                 175     


Glu Ser Gly Asn Lys Leu Asn Gln Asn Gly Leu Val Phe Phe Thr Cys 
            180                 185                 190         


Leu Phe Leu Asp Arg Glu Asp Ala Phe His Phe Ile Asn Arg Val Tyr 
        195                 200                 205             


Gly Leu Lys Gly Thr Gln Thr Arg Glu Phe Gln Ala Thr Arg Glu Val 
    210                 215                 220                 


Phe Cys Ala Tyr Cys Val Arg Leu Pro Tyr Asp Lys Phe Ile Ser Glu 
225                 230                 235                 240 


Asp Thr Thr Gln Ala Leu Ser Leu Asp Ile Leu Asn Glu Leu Asn Arg 
                245                 250                 255     


Cys Pro Lys Glu Leu Phe Asp Cys Met Asp Glu Gln Ser Lys Lys Glu 
            260                 265                 270         


Phe Gln Pro Glu Ile Gly Ser Glu Glu Lys Glu Asn Ile Ile Lys Ser 
        275                 280                 285             


Ser Ile Asn Pro Glu Thr Ile Glu Glu Glu Asp Tyr Glu Glu Tyr Val 
    290                 295                 300                 


Arg Arg Ile Ser Ser Arg Lys Arg Asn Asn Asp Arg Phe Asp Tyr Phe 
305                 310                 315                 320 


Ala Leu Thr Tyr Leu Asp Ser Leu Asp Asp Ser Asn Ile Asn Phe His 
                325                 330                 335     


Leu Asn Leu Gly Lys Gly Cys Ile Arg Ser Tyr Lys Lys Ala Phe Asn 
            340                 345                 350         


Gly Glu Gln Ile Asp Arg Glu Ile Val Glu Asp Val Lys Ile Phe Lys 
        355                 360                 365             


Lys Leu His Asp Val Lys Ser Arg Asp Val Ile Glu Asp Glu Lys Lys 
    370                 375                 380                 


Met Val Gln Leu Ile Asp Lys Arg Lys Leu Glu Ser Glu Asp Glu Arg 
385                 390                 395                 400 


Phe Ala Phe Thr Thr Phe Asn Pro His Phe His Ile Ala Asn Asn Lys 
                405                 410                 415     


Ile Gly Leu Arg Leu Cys Gln Gly Asn Ala Ala Leu Lys Thr Asn Gln 
            420                 425                 430         


Glu Gly Gln Pro Asn Leu Lys Leu Pro Ser Pro Glu Val Phe Leu Ser 
        435                 440                 445             


Ile His Glu Leu Pro Lys Leu Leu Leu Leu Glu Leu Leu Gln Lys Gly 
    450                 455                 460                 


Lys Ala Glu Val Leu Ile Lys Asp Phe Ile His Ser Asn Val Ser Leu 
465                 470                 475                 480 


Ile Leu Asn Ala Thr Lys Ile Glu Glu Ile Lys Gln Arg Ile Asp Leu 
                485                 490                 495     


Pro Leu Val Lys Lys Arg Glu Val Gln Gly Lys Gln Thr Phe Lys Asp 
            500                 505                 510         


Met Glu Ala Tyr Ser Ala Glu Ile Asn Lys Arg Lys Lys Cys Leu Asp 
        515                 520                 525             


Asn Ile Leu Pro Ser Tyr Asn Leu Asn Ile Arg Gln Ile Pro Ser Arg 
    530                 535                 540                 


Ile Ile Asp Tyr Trp Leu Asn Ile Val Asp Val Ser Pro Glu Lys Asn 
545                 550                 555                 560 


Phe Glu Phe Arg Thr Lys Ala Leu Leu Lys Asp Cys Lys His Arg Leu 
                565                 570                 575     


Glu Asn Leu Glu Gln Ser Asn Lys Ser Pro Lys Val Gly Gln Met Ala 
            580                 585                 590         


Thr Phe Leu Ala Lys Asp Leu Val Asp Met Val Ile Asp Asn Thr Pro 
        595                 600                 605             


Gln Leu Ser Val Lys Asn Lys Ile Thr Ser Phe Tyr Tyr Asn Lys Leu 
    610                 615                 620                 


Gln Glu Ser Leu Ala Leu Phe Ser Gly Ile Glu His Lys Glu Val Phe 
625                 630                 635                 640 


Tyr Val Leu Cys Ser Thr Lys Glu Cys Gly Phe Asp Ser Pro Asn Ile 
                645                 650                 655     


His Pro Phe Leu Tyr Lys Thr Asn Tyr Arg Arg Ala Lys Asn Ile Ser 
            660                 665                 670         


Glu Leu Tyr Lys Ser Tyr Leu Asn Gln Lys Gln Asn Trp Ile Glu Lys 
        675                 680                 685             


Cys Phe Tyr Val Lys Gln Gly Gln Lys Thr Lys Ile Ile Leu Pro Asp 
    690                 695                 700                 


Glu Thr Leu Glu Pro Tyr Ser Lys Ile Pro Phe Thr Ile Lys Asn Gln 
705                 710                 715                 720 


Ile Arg Pro Thr Ser Asp Phe Asn Asp Trp Leu Lys Asn Val Thr His 
                725                 730                 735     


Lys Pro Ile Asp Leu Pro Thr Asn Leu Phe Asp Glu Thr Leu Cys His 
            740                 745                 750         


Leu Leu Arg Glu Lys Thr Gly Leu Ser Asn Asp Asn Lys Glu Lys Tyr 
        755                 760                 765             


Ser Val Leu Leu Ala Arg Trp Met Glu Asn Asp Thr Gln Pro Phe Tyr 
    770                 775                 780                 


Asn Ser Asp Arg Val Tyr Lys Val Tyr Asp Glu Thr Val Thr Phe Thr 
785                 790                 795                 800 


Pro Gly Thr Lys Lys Ala Tyr Lys Asp Tyr Phe Gln Asp Ala Met Lys 
                805                 810                 815     


Lys Pro Phe Lys Leu Arg Lys Ser Glu Asn Ser Lys Leu Glu Ile Glu 
            820                 825                 830         


Asn Ile Arg Ser Val Phe Asn His Ala Ile Val Asp Asn Glu Lys Asn 
        835                 840                 845             


Ile Arg Tyr Ser Gln Thr Lys Asp Arg Ile Leu Leu Leu Leu Phe Arg 
    850                 855                 860                 


Glu Leu Cys Lys Asp Gly Val Phe Asn Lys Leu Lys Leu Cys Thr Ile 
865                 870                 875                 880 


Lys Asp Ala Leu Asn Gln Asn Val Ser Val Lys Glu Ser Ile Ser Gly 
                885                 890                 895     


Lys Pro Lys Asn Gly Asn Glu Leu Ser Arg Thr Val Val Gly Glu Arg 
            900                 905                 910         


Lys Met Lys Asp Phe Ser Val Phe Arg Lys Leu Ile Phe Asp Arg Arg 
        915                 920                 925             


Leu Pro Asp Leu Phe Glu Tyr Tyr Glu Thr Glu Glu Ile Pro Tyr Leu 
    930                 935                 940                 


Lys Leu Ile Asp Glu Leu Asn Ser Tyr Asn Ala Val Lys Glu Leu Val 
945                 950                 955                 960 


Phe Asp Arg Val Phe Glu Leu Glu Lys Ala Ile Met Ser Lys Ser Val 
                965                 970                 975     


Phe Lys Ser Glu Ile Ile Gly Met Val Asp Asn Glu Thr Asn Val Gln 
            980                 985                 990         


His Lys Pro Tyr Leu Ser Trp Leu  Leu His Lys Gly Leu  Ile Ser Gln 
        995                 1000                 1005             


Ser Asp  Tyr Asn Phe Leu Leu  Glu Ile Arg Asp Ala  Phe Ser His 
    1010                 1015                 1020             


Ser Gln  Phe Pro Gln Gln Asn  Glu Val Gly Arg Phe  Met Asn Arg 
    1025                 1030                 1035             


Asp Cys  Asn Lys Ser Phe Ser  Val Gln Ile Phe Glu  Lys Tyr Asp 
    1040                 1045                 1050             


Glu Lys  Met Lys Glu Val Ile  Lys Lys Ile Glu Ala  Ile Gly 
    1055                 1060                 1065         


<210>  2646
<211>  1124
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2646

Met Thr Leu Pro Ile Asn Asn Thr Phe Thr Ser Arg Ala Asp Arg Glu 
1               5                   10                  15      


Ile Leu Ser Gln Asn Lys Leu Phe Phe Gly Thr Tyr Leu Asn Met Ala 
            20                  25                  30          


Gln His Asn Thr Phe Leu Met Leu Thr Asp Ser Ser Glu Lys Val Gly 
        35                  40                  45              


Lys Thr Pro Pro Ser Ser Glu Gly Leu Trp Lys Asp Ala Gly Thr Phe 
    50                  55                  60                  


Ser Leu Leu Asn Thr Gln Gln Arg Pro Ser Ile Arg Ser Lys Ala Gly 
65                  70                  75                  80  


Arg Leu Ala Val Lys Gln Phe Val Ala Leu Glu Ser Leu Val Ile Glu 
                85                  90                  95      


Arg Glu Glu Gly Glu Ala Glu Thr Pro Pro Asp Val Glu Lys Leu His 
            100                 105                 110         


Asp Phe Leu Tyr Ser Ala Leu Glu Leu Leu Asn Asn Leu Arg Arg Glu 
        115                 120                 125             


Tyr Ser His Tyr Tyr His Glu Thr Ala Gln Asn Ile Asp Tyr Pro Lys 
    130                 135                 140                 


Leu Glu Ala Ile Phe Arg Glu Ala Lys Arg Val Ala Ile Glu Arg Leu 
145                 150                 155                 160 


Pro Lys Asp Asp Asp Lys Ala Lys Asn Lys Ala Glu Lys Lys Ile Val 
                165                 170                 175     


Lys Tyr Met Leu Arg Asn Glu Asp Glu Lys Leu Val Phe Phe Ile Ser 
            180                 185                 190         


Leu Phe Leu Ser Arg Gln Gln Ala Glu Ala Phe Met Ser Gln Ile Asn 
        195                 200                 205             


Asp Phe Lys Gly Glu His Asn Ala Leu Lys Arg Arg Val Phe Ala Gln 
    210                 215                 220                 


Leu Cys Cys Arg Leu Pro Arg Pro Lys Leu Glu Ser Ala Ala Leu Glu 
225                 230                 235                 240 


Leu Asp Ala Leu Asn Glu Leu Ala Arg Cys Pro Asp Glu Val Phe Arg 
                245                 250                 255     


Tyr Leu Asn Thr Glu Asp Lys Asn Arg Phe Val Val Pro Leu Lys Glu 
            260                 265                 270         


Leu Asp Lys Asp Asp Thr Ser Gly Asn Thr Ile Thr Leu Lys Arg Tyr 
        275                 280                 285             


Glu Asp Arg Leu Pro Tyr Leu Leu Met Arg Tyr Leu Asp Glu His Ala 
    290                 295                 300                 


Glu Asn Phe Gly Ile His Phe Gln Ile Trp Ala Gly Lys Leu Arg Thr 
305                 310                 315                 320 


Ala Asp Tyr Pro Lys Thr Ile Tyr Asp Ile Glu Asp Asn Arg Asn Ile 
                325                 330                 335     


His Glu Asn Leu Thr Ala Tyr Asp Thr Leu Gln Asn Leu Arg Asn Gly 
            340                 345                 350         


Asp Asn Ile Pro Asp Asn Trp Lys Met Gln Asp Gly Glu Leu Leu Thr 
        355                 360                 365             


Lys Ile Glu Gln Phe Ser Pro His Tyr Asn Ile Ile Asn Asn Arg Ile 
    370                 375                 380                 


Ala Leu Lys Leu Gly Asp Thr Ala Tyr Thr Glu Ile Tyr Pro Leu Ser 
385                 390                 395                 400 


Glu Asp Ser Lys Leu Asp Phe Arg Val Lys Asn Pro Leu Pro Asp Leu 
                405                 410                 415     


Ile Ile Ser Thr Tyr Asp Ile Pro Asn Leu Phe Leu Tyr Gln Tyr Leu 
            420                 425                 430         


His Gln Gln Gly Lys Ile Arg Leu Arg Pro Asp Ile Phe Ile Arg Gln 
        435                 440                 445             


Phe Ser Gly Lys Leu Arg Lys Val Phe Lys Asp Val Gln Ser Gly Glu 
    450                 455                 460                 


Leu Lys Pro Leu Gln Ala Glu Ala Phe Glu Lys Gln Gln Arg Tyr Ser 
465                 470                 475                 480 


Glu Arg Arg Gln Glu Ile Leu Glu Glu Arg Arg Ser Gln Leu Gln Ala 
                485                 490                 495     


Ile Leu Asp Asn Lys Tyr Lys Leu Val Lys Val Ser His Leu Pro Asp 
            500                 505                 510         


Ala Leu Arg Glu Tyr Leu Phe Asn Tyr Lys Ala Gln Asp Phe Asn Arg 
        515                 520                 525             


Gln Val Leu His Lys Ile Thr Glu Arg Met Glu Ala Asp Trp Gln Arg 
    530                 535                 540                 


Lys Lys Lys Ala Glu Tyr Gly Ser Gly Thr Asp Glu Pro Glu Leu Lys 
545                 550                 555                 560 


Ala Gly Asn Ile Gly Thr Tyr Ile Ala Arg Asp Ile Val Ala Leu Gln 
                565                 570                 575     


Pro Pro Asn Pro Gln Glu Val Asn Leu Gly Lys Pro Asn Asn Asp Gln 
            580                 585                 590         


Tyr Asn Glu Leu Gln Glu Ser Ile Ala Tyr Phe Gly Arg Glu Tyr His 
        595                 600                 605             


Val Leu Pro Ala Tyr Leu Arg Lys Glu Leu Gly Val Met Gly Glu Arg 
    610                 615                 620                 


Asn Asp Lys Thr Lys His Pro Phe Leu Val His Leu Asn Trp Asn Lys 
625                 630                 635                 640 


Cys His Thr Ala Lys Glu Phe Tyr Ile Glu Tyr Leu Asp Val Lys Arg 
                645                 650                 655     


Arg Trp Met Arg Ala Val Arg Asp Asp Ile Lys Ala Val Ser Pro Gln 
            660                 665                 670         


Thr Glu Gln Pro His Phe Val Lys Met Gln Arg Asn Ala Lys His Phe 
        675                 680                 685             


Gly Ile Asn Ile Asn Lys Ser Ala Leu Thr Asp Glu Gln Ile Gln Glu 
    690                 695                 700                 


Arg Tyr Gly Tyr Phe Leu Arg Ile Asn Ser Lys Ala Ala Lys Asp Arg 
705                 710                 715                 720 


Asn Tyr Leu Lys Thr Met Arg Lys Asn Pro Ile Ser Gly Asp Phe Glu 
                725                 730                 735     


Pro Thr Asp Asn Ala Pro Ile Met Leu Pro Arg Gly Ile Phe Asn Asp 
            740                 745                 750         


Ala Ile Arg Glu Ala Leu Arg Thr Asn Tyr Pro Asp Gln Ile Asn Asp 
        755                 760                 765             


Lys Ser Gly Met Ser Asp Phe Thr Arg Ile Met Ala Asn Asp Glu Asp 
    770                 775                 780                 


Leu Gln Thr Cys Tyr Ser Tyr Pro Arg His Tyr Arg Tyr Glu Ala Asp 
785                 790                 795                 800 


Asn Asp Lys Leu Phe Lys Asn Asp Arg Glu Lys Ala Arg His Thr Ile 
                805                 810                 815     


Asp Ile Lys Gly Asp Thr Ala Gln Ile Trp Gln Gly Leu Cys Asp Leu 
            820                 825                 830         


Lys Thr Glu Leu Lys Asp Asn Leu Thr Arg Ala Lys Asn Ser Gln Leu 
        835                 840                 845             


Lys Arg Leu Phe Glu Gln Val Asp Arg Gln Lys Lys Leu Trp Arg Arg 
    850                 855                 860                 


Ile Phe Arg Asn Glu Gln Ala Ile Arg Thr Val Ala Phe Lys Asp Arg 
865                 870                 875                 880 


Leu Val Trp Leu Met Val Lys Asp Ile Leu Thr Arg Lys Ser Gln Ala 
                885                 890                 895     


Glu Gln Ser Asn Leu Gln Leu Glu Gln Trp Gln Leu Gln Asp Thr Gly 
            900                 905                 910         


Phe Asp Val Arg Lys Thr Glu Val Trp Ile Leu Asp Gln Ala Ile Pro 
        915                 920                 925             


Thr Ser Leu Thr Ile His Asp Lys Asp Ile Cys Ala Asn Phe Gln Ser 
    930                 935                 940                 


Ala Glu Leu Asp Lys Ala Arg Glu Asn Glu Leu Pro Val Lys Arg Tyr 
945                 950                 955                 960 


Gly Glu Phe Arg Lys Met Leu Lys Asp Arg Arg Leu Phe Val Ala Asn 
                965                 970                 975     


Asn Ser Gly Leu Leu Arg Tyr Tyr Pro Glu Lys Ser Ile Leu Trp Thr 
            980                 985                 990         


Thr Leu Gln Asp Glu Leu Arg Asp  Tyr Asp Gln Cys Arg  Ala Glu Leu 
        995                 1000                 1005             


Leu Asn  Ala Ile Phe Ala Phe  Glu Gln Arg Val Leu  Ser Asn Gln 
    1010                 1015                 1020             


Gln Cys  Arg Gln His Leu Ser  Leu Thr Glu Asn Arg  Ile Asp His 
    1025                 1030                 1035             


Lys Val  Tyr Leu Glu Ala Tyr  Lys Ala Thr Tyr Gly  Asn Met Pro 
    1040                 1045                 1050             


Gln Pro  Ile Ser Asn Ile Asn  Gln Leu Arg Asn Lys  Phe Met His 
    1055                 1060                 1065             


Asn Gln  Ile Pro Tyr Asp Thr  Trp Ile Ser Gln Ala  Ile Glu His 
    1070                 1075                 1080             


Asn Thr  Asn Ala Asn Leu Pro  Ile Glu Asp His Arg  Asn Lys Asn 
    1085                 1090                 1095             


Val Val  Lys Gln Leu Ile Glu  Phe Ala Thr Glu Leu  Tyr Asp Gly 
    1100                 1105                 1110             


Met Asn  Glu Ile Leu Phe Tyr  Asn Lys Glu Asn 
    1115                 1120                 


<210>  2647
<211>  1129
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2647

Met Glu Thr Asn Gln Gln Thr His Glu Asn Arg Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Asn Asn His Ile Ala Thr Asp Phe Lys Gln Ala Thr 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ala Ala Phe Leu Cys Asn Lys Thr 
    50                  55                  60                  


Ile Lys Asn Leu Asn Trp Asn His Val His Thr Arg Ala Val Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ser Glu Ser Leu Pro Lys Asp Glu 
                85                  90                  95      


Arg Glu Asn Ser Asp Thr Glu Gly Lys Asp Phe Ala Ser Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Ser Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gln Asp Ser Arg Lys Leu Thr Val 
    130                 135                 140                 


Ser Pro Glu Leu Ala Asn Phe Leu Thr Val Asn Phe Gln Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Ala Arg Met Lys Asp Val Leu Thr Asp Ala Asp Tyr 
                165                 170                 175     


Ala Leu Val Glu Asn Leu Gln Met Val Ala Pro Asp Asn Lys Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ala Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Thr Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asn Leu Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Ser 
            260                 265                 270         


Val Ile Thr Asp Lys Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Asp Asp Glu Arg 
    290                 295                 300                 


Glu Arg Ile Leu Asp Glu Ile Asp Tyr Gln Asp Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg Tyr Ser Asn Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Asp Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Asn Tyr Thr Lys Gln Phe Ala Gly Glu 
        355                 360                 365             


Gln Ala Glu Arg Lys Val Leu Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asp Pro Glu Leu Ile Gln Gln Arg Ile Asp Lys Gln 
385                 390                 395                 400 


Gln His Thr Ala Gly Phe Asp Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Thr Lys Glu Asn Ile Ala Thr Leu Ile 
            420                 425                 430         


Ala Lys Ser Lys Ala Ser Ser Lys Val Glu His Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Gln Ala Glu Glu Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Ile Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Ser Gln Leu Pro Ala Asp Trp Asp Glu Phe Ser Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asp Ser Thr Leu Lys Tyr Leu 
        515                 520                 525             


Arg Gln Arg Lys Thr Thr Leu Asn Thr Ile Leu Ser Lys Ser Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Lys Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Thr Arg Leu Lys Ala Val Glu Lys His Lys Leu 
            580                 585                 590         


Asn Lys Ser Val Lys Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Glu Glu Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Ala Asn Ala Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Asn Asp Gly His Pro Phe Leu Gln Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Gln Ala Tyr Leu Ile 
        675                 680                 685             


Glu Lys Gly Asn Lys Met Val Pro Arg Leu Asn Pro Lys Thr Asn Lys 
    690                 695                 700                 


Thr Ser Lys Val Asp Glu Ser Trp Met Met Lys Gln Phe Tyr Val Lys 
705                 710                 715                 720 


Glu Trp Lys Glu Glu Ile Gly Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Ser Arg Ile Pro Phe Thr Ile Cys Gln Trp Asp Lys Lys 
            740                 745                 750         


Glu Ser His Asp Leu Asn Thr Trp Leu Gln His Val Thr Val Gly Lys 
        755                 760                 765             


Asn Lys Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe Asp 
    770                 775                 780                 


Glu Ala Leu Cys Asp Leu Leu Arg Glu Gln Leu Asp Thr Lys Ile Val 
785                 790                 795                 800 


Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Ile Trp Trp 
                805                 810                 815     


Lys Thr Arg Asn Asp Asp Thr Gln Gln Phe Tyr Gln Ser Glu Arg Glu 
            820                 825                 830         


Tyr Asp Ile Tyr Asn Glu Lys Val Arg Phe Lys Ile Asp Ser Ser Ala 
        835                 840                 845             


His Phe Ala Asp Tyr Tyr Lys Asn Ala Leu Ser Arg Ala Phe Thr Arg 
    850                 855                 860                 


Leu Lys Ala Glu Arg Glu Thr Ala Arg Gln Thr Asn Lys Lys Leu Pro 
865                 870                 875                 880 


Pro Leu Glu Tyr Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile Ala 
                885                 890                 895     


Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met Ala 
            900                 905                 910         


Val Leu Met Leu Glu Arg Leu Met Asp Asn Ser Pro Asn Leu Arg Leu 
        915                 920                 925             


Ser Lys Ile Glu Thr Leu Leu Asn Asp Thr Thr His Ile Ser Glu Lys 
    930                 935                 940                 


Ile Ser Ala Thr Leu Ser Phe Asp Ala Ser Gly Glu Arg Ile Ser Gly 
945                 950                 955                 960 


Lys Leu Lys Gln Thr Val Thr Lys Thr Leu Ile Ala Glu Arg Lys Gln 
                965                 970                 975     


Lys Asn Tyr Thr Glu Leu Arg Lys Tyr Arg Tyr Asp Arg Arg Leu Pro 
            980                 985                 990         


Glu Leu Phe Glu Tyr Val Gln Ala  Asp Glu Ile Pro Leu  Glu Trp Leu 
        995                 1000                 1005             


Leu Glu  Glu Leu Ser Ala Tyr  Asn Asn Ala Lys Gln  Gln Val Phe 
    1010                 1015                 1020             


Asp Thr  Val Phe Ala Leu Glu  Lys Lys Ile Val Gly  Thr Asp Pro 
    1025                 1030                 1035             


Asp Gly  Leu Lys Ser Leu Phe  Thr Asn Pro Lys Gly  Glu Pro Leu 
    1040                 1045                 1050             


Lys Gly  Asn Ile Gln His Lys  Pro Tyr Val Gln Trp  Leu Thr Asn 
    1055                 1060                 1065             


Lys Gly  Leu Ile Asn Lys Glu  Glu Lys Gln Phe Ile  Asn Met Val 
    1070                 1075                 1080             


Arg Lys  Cys Phe Ser His Asn  Gln Phe Pro Gln Arg  Lys Thr Met 
    1085                 1090                 1095             


Glu Leu  Leu Ile Pro Ala Trp  Asn Glu Lys Lys Leu  Ala Leu Gln 
    1100                 1105                 1110             


Ile Ala  Thr Val Tyr Asn Gln  Leu Ile Ala Asp Leu  Thr Asp Lys 
    1115                 1120                 1125             


Ile 
    


<210>  2648
<211>  1119
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2648

Met Asp Thr Ile Glu Arg Ile Glu Ile Lys Ser Ala Asn Val Tyr Lys 
1               5                   10                  15      


Thr Leu Glu Asn Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala 
            20                  25                  30          


Arg Leu Asn Ile Phe Ser Ile Asn Asn Ser Val Ala Asp Lys Ile Lys 
        35                  40                  45              


Val Ala Pro Ile Pro Asn Glu Glu Lys Ile Leu Asp Ser Phe Leu Cys 
    50                  55                  60                  


Asn His Asn Arg Lys His Leu Asn Trp Asn Leu Ala His Ala Ile Ala 
65                  70                  75                  80  


Val Lys Phe Leu Pro Ile Ile Lys Val Phe Asn Phe Glu Gly Leu Pro 
                85                  90                  95      


Lys Ser Glu Arg Thr Ser Asp Phe Asn Asn Ile Asn Thr Gly Lys Asp 
            100                 105                 110         


Phe Ala Ala Met Ala Asp Ala Leu Arg Ser Leu Phe Gly Glu Ile Gln 
        115                 120                 125             


Glu Phe Arg Asn Asp Tyr Ser His Tyr Tyr Ser Ile Thr Asn Gly Asn 
    130                 135                 140                 


Lys Arg Lys Thr Thr Ile Ser Lys Glu Val Ala Glu Phe Leu Asn Lys 
145                 150                 155                 160 


Asn Phe Ala Arg Ala Ile Glu Tyr Thr Lys Asp Arg Phe Asn Gly Val 
                165                 170                 175     


Leu Asn Asn Glu Asp Phe Tyr His Val Lys Glu Arg Val Leu Val Asn 
            180                 185                 190         


Lys Asp Asn Thr Ile Thr Thr Asp Gly Leu Val Phe Leu Ile Ala Met 
        195                 200                 205             


Phe Leu Glu Arg Glu His Ala Phe Gln Phe Ile Gly Lys Ile Lys Gly 
    210                 215                 220                 


Leu Lys Gly Thr Gln Tyr Asn Ser Phe Ile Ala Thr Arg Glu Val Leu 
225                 230                 235                 240 


Met Ala Phe Cys Ala Lys Leu Pro His Asp Arg Phe Val Ser Glu Asp 
                245                 250                 255     


Lys Lys Gln Ala Phe Thr Leu Asp Ile Ile Asn Thr Leu Asn Arg Cys 
            260                 265                 270         


Pro Lys Glu Leu Tyr Ala Val Ile Thr Glu Glu Glu Arg Lys Ala Phe 
        275                 280                 285             


Lys Pro Asn Leu Asp Ser Leu Lys Ile Glu Asn Leu Leu Asn Asn Ser 
    290                 295                 300                 


Thr Asn Asp Arg Ala Asp Ile Glu Asn Tyr Asp Lys Tyr Ile Glu Ala 
305                 310                 315                 320 


Leu Thr Arg Lys Val Arg His Ser Asn Arg Phe Ser Tyr Cys Ala Leu 
                325                 330                 335     


Lys Phe Ile Asp Glu Thr Asn Ile Phe Lys Gln Leu Arg Phe Gln Ile 
            340                 345                 350         


Asn Leu Gly Lys Leu Gly Leu Asp Glu Tyr Glu Lys Pro Ile Asn Asn 
        355                 360                 365             


Glu Leu Tyr Pro Arg Ser Ile Val Gln Asn Val Lys Ala Phe Gly Lys 
    370                 375                 380                 


Leu Ser Asp Phe Glu Asp Glu Lys Glu Val Leu Lys Gln Ile Asp Lys 
385                 390                 395                 400 


Glu Gly Asn Ser Leu Gly Phe Asp Gln Tyr Ala Pro Phe Tyr Asn Thr 
                405                 410                 415     


Lys Asn Asn Lys Ile Gly Leu His Thr Asn Asn Ala Lys Ser Ile Val 
            420                 425                 430         


Ile Asn Lys Ala Lys Ser Glu Ser Lys Ile Lys Asn Lys Leu Lys Lys 
        435                 440                 445             


Ala Leu Pro Glu Ala Phe Leu Ser Leu Asn Glu Leu Pro Lys Ile Ile 
    450                 455                 460                 


Val Leu Glu Tyr Leu Glu Lys Gly Lys Ser Glu Glu Leu Ile Asn Asp 
465                 470                 475                 480 


Phe Ile Leu Ala Ser Asn Ser Lys Ile Thr Asn Lys Gln Phe Ile Asp 
                485                 490                 495     


Glu Val Lys Gly Lys Leu Pro Asn Asp Trp Asn Lys Phe Asn Lys Arg 
            500                 505                 510         


Ser Asp Ser Lys Lys Gly Thr Ala Tyr Lys Pro Ser Ala Leu Ala Tyr 
        515                 520                 525             


Leu Arg Asn Arg Lys Arg Thr Leu Asp Glu Val Leu Ala Gln Tyr Asp 
    530                 535                 540                 


Leu Asn His Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp Leu Ser 
545                 550                 555                 560 


Val Val Asp Ile Asn Ser Glu Arg Ala Ile Ser Asp Arg Ile Lys Gln 
                565                 570                 575     


Met Lys Arg Glu Gly Met Asp Arg Leu Lys Val Tyr Gln Lys Tyr Lys 
            580                 585                 590         


Lys Thr Gly Lys Gly Arg Ile Pro Lys Ile Gly Glu Met Ala Thr Tyr 
        595                 600                 605             


Leu Ala Lys Asp Ile Val Asp Leu Ile Ile Ser Thr Asp Lys Lys Lys 
    610                 615                 620                 


Lys Ile Thr Ser Phe Tyr Tyr Asp Lys Ile Gln Glu Cys Leu Ala Leu 
625                 630                 635                 640 


Phe Ala Asp Pro Asp Lys Lys Ala Leu Phe Ile Asp Ile Ile Ser Lys 
                645                 650                 655     


Glu Leu His Leu Asn Glu Leu Asp Gly His Pro Phe Leu Lys Tyr Ile 
            660                 665                 670         


Arg Phe Ser Lys Ile Ser Tyr Thr Gln Asp Leu Tyr Glu Ser Tyr Leu 
        675                 680                 685             


Gln Glu Lys Ala Asn Lys Met Ile Asp Val Lys Asn His Arg Thr Gly 
    690                 695                 700                 


Arg Thr Asn Gln Ile Asp Lys Ser Trp Met Met Thr Thr Phe Tyr Arg 
705                 710                 715                 720 


Arg Glu Trp Asn Lys Glu Ala Gly Lys Gln Leu Thr Glu Val Lys Leu 
                725                 730                 735     


Pro His Asn Leu Ser Cys Ile Pro Phe Ser Leu Arg Gln Leu Lys Glu 
            740                 745                 750         


Lys Thr Ser Asn Asn Leu Asp Glu Trp Leu His Asn Ile Thr Lys Gly 
        755                 760                 765             


Lys Glu Val Asn Asp Gly Lys Lys Pro Ile Asn Leu Pro Thr Asn Leu 
    770                 775                 780                 


Phe Asp Glu Thr Leu Ile Arg Leu Leu Lys Ser Glu Leu Asp Thr Gln 
785                 790                 795                 800 


His Glu Gln Tyr Pro Thr Asp Ala Lys Tyr Asn Glu Leu Phe Lys Ile 
                805                 810                 815     


Trp Trp Arg Asn Arg Gly Asp Ser Thr Gln Ser Phe Tyr Asn Ala Glu 
            820                 825                 830         


Arg Glu Tyr Leu Ile Tyr Asp Glu Lys Val Asn Phe Lys Leu Gln Glu 
        835                 840                 845             


Asn Ala Glu Phe Ala Asp Phe Tyr Ser Asp Asn Leu Arg Lys Ala Tyr 
    850                 855                 860                 


Lys Ala Lys Gln Ala Asp Arg Arg Ile Glu Lys Arg Thr Asn Arg Arg 
865                 870                 875                 880 


Leu Pro Asp Val Gln Phe Ser Asp Val Glu Lys Val Phe Lys Arg Thr 
                885                 890                 895     


Ile Ser Asn Thr Glu Lys Gln Ile Arg Leu Leu Lys Glu Glu Asp Gln 
            900                 905                 910         


Ile Met Leu Leu Met Leu Glu Lys Leu Met Thr Ser Asp Gln Asp Leu 
        915                 920                 925             


Asn Leu Lys Leu Ser Gln Ile Asp Thr Leu Leu Asn Asp Thr Ile Thr 
    930                 935                 940                 


Val Lys Lys Ser Val Ser Gly Gln Leu Ser Phe Asp Asn Asn Ala Glu 
945                 950                 955                 960 


Ile Thr Lys Ile Ile Ile Asp Gln Arg Lys Arg Lys Asp Phe Ser Met 
                965                 970                 975     


Leu His Lys Tyr Ser Phe Asp Arg Arg Leu Pro Glu Leu Phe Glu Tyr 
            980                 985                 990         


Phe Lys Glu Ser Glu Ile Pro Leu  His Asp Leu Lys Asn  Glu Leu Glu 
        995                 1000                 1005             


Ala Tyr  Asn Asn Ala Lys Gln  Met Val Leu Asp Ala  Ala Phe Asn 
    1010                 1015                 1020             


Leu Glu  Lys Ala Val Ile Thr  Asn Asn Asn Ala Glu  Asp Leu Ile 
    1025                 1030                 1035             


Asp Pro  Asp Tyr Arg Asn Gly  His Ile Gln His Lys  Leu Tyr Leu 
    1040                 1045                 1050             


Gln Trp  Leu Lys Lys Glu Gly  Lys Ile Asn Glu Asn  Glu Phe Ser 
    1055                 1060                 1065             


Phe Leu  Asn Met Val Arg Asn  Ser Phe Ser His Asn  Gln Tyr Pro 
    1070                 1075                 1080             


Gln Lys  Thr Thr Met Ser Leu  Phe Val Asn Gln Trp  Ala Asp Asn 
    1085                 1090                 1095             


Asn Phe  Ala Leu Gln Ile Ala  Glu Ile Tyr Asn Val  Lys Ile Asp 
    1100                 1105                 1110             


Ser Thr  Ile Ala Lys Tyr 
    1115                 


<210>  2649
<211>  994
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2649

Met Asp Ser Lys Tyr Ile Leu Gly Ser Tyr Leu Asn Met Ala Asn Asp 
1               5                   10                  15      


Asn Phe Ile Asn Thr Ile His Leu Leu Ala Lys Lys Leu Lys Thr Pro 
            20                  25                  30          


Lys Gly Glu Asp Gln Asn Leu Asp Gln Val Val Ser Tyr Ile Thr Arg 
        35                  40                  45              


Ile Phe Asp Asn Ser Asn Gln Val Pro Glu Thr Glu Gln Ile Val Glu 
    50                  55                  60                  


Phe Tyr Phe Pro Trp Leu Glu Ala Leu Lys Asn Ala Asn Gly Phe Gly 
65                  70                  75                  80  


Lys Ser Glu Leu Pro Glu Leu Lys Ile Phe Tyr Lys Asp Val Leu Cys 
                85                  90                  95      


Ser Phe Ala Glu Asn Leu Lys Asp Leu Arg Asn Asn Tyr Thr His Tyr 
            100                 105                 110         


Ile His Lys Thr Ile Ser Tyr His Pro Ile Ile Tyr Lys Lys Glu Gly 
        115                 120                 125             


Asn Thr Leu Gln Ser Ser Leu Pro Lys Ala Leu Leu Gln Ile Tyr Asp 
    130                 135                 140                 


Ala Ser Ile Lys Leu Ala Lys Glu Arg Phe Ser Ala Asp Glu Asn Ala 
145                 150                 155                 160 


Val Thr His Leu Arg Arg Tyr Lys Met Val Gly Lys Lys Val Val Arg 
                165                 170                 175     


Lys Thr Glu Ala Asp His Phe Leu Tyr Leu Leu Glu Lys Asp His Leu 
            180                 185                 190         


Leu Thr Glu Lys Gly Ile Ala Phe Phe Thr Ser Leu Phe Leu Asn Arg 
        195                 200                 205             


Lys Tyr Gly Tyr Leu Met Leu Lys Gln Leu Lys Gly Phe Lys Gln Gly 
    210                 215                 220                 


Gly Thr Leu Ala Tyr Arg Leu Thr Leu Glu Thr Phe Leu Ala Tyr Ser 
225                 230                 235                 240 


Asn Ile Lys Pro Val Glu Arg Leu Lys Ala Asp Lys Tyr Ser Asp Val 
                245                 250                 255     


Ala Phe Ile Met Asp Leu Leu Gly Glu Ile Ser Lys Ile Pro Lys Glu 
            260                 265                 270         


Leu Tyr His Ile Leu Pro Glu Thr Tyr Ile Leu Gln Tyr Lys Asn Lys 
        275                 280                 285             


Leu His Ile Glu Leu Asn Glu Asp Ile Ser Leu Glu Ala Tyr Cys Ser 
    290                 295                 300                 


Arg Gly Arg Asn Arg Phe Asp Gln Leu Ala Leu Thr Tyr Leu Asp Arg 
305                 310                 315                 320 


Leu Glu Asp Phe Lys Gln Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr 
                325                 330                 335     


Ile His Asn Gly Tyr Met Lys Val Arg Ile Asp Gly Thr Glu Gln Glu 
            340                 345                 350         


Arg Tyr Leu Ser Glu Lys Met Tyr Gly Cys Cys Lys Asn Ile Tyr Arg 
        355                 360                 365             


Asp Leu Ser Ala Ile Val Ala Lys Gln Tyr Asn Ile Lys Val Lys Asp 
    370                 375                 380                 


Ser Thr Glu Thr Ser Tyr Met Leu Pro Asn Asp Phe Gln Pro His Val 
385                 390                 395                 400 


Ile Arg Ala Tyr Pro His Tyr Val Ile Asn Asn Asn Asn Ile Gly Ile 
                405                 410                 415     


Arg Leu Leu Asp Glu Gly Glu Ser Gly Phe Pro Ile Leu Glu Asn Arg 
            420                 425                 430         


Gly Thr Lys Asn Val Val Pro His Phe Trp Met Ser Lys Tyr Asp Leu 
        435                 440                 445             


Pro Ala Leu Leu Phe Tyr Ala Tyr Leu Arg Ser Asp Ser Arg Phe Ala 
    450                 455                 460                 


Ser Lys Cys Lys Lys Thr Ile Asp Glu Ile Leu Arg Gly Tyr Leu Ser 
465                 470                 475                 480 


Lys Ser Lys Asp Lys Lys Pro Lys Gln Ala Glu Lys Val Ser Val Leu 
                485                 490                 495     


Met Leu Arg Arg Ile Asp Lys Ala Ile Ile Trp Thr Gln Thr Lys Leu 
            500                 505                 510         


Asn Glu Ala Glu Lys Gln Arg Asp Asn Lys Lys Ser Phe Lys Ile Gly 
        515                 520                 525             


Glu Lys Ala Asp Ile Leu Ala His Asp Met Leu Trp Leu Gln Pro Ala 
    530                 535                 540                 


Lys Glu Ser Lys Asp Lys Val Ser Gly Ala Asn Phe Arg Ala Leu Gln 
545                 550                 555                 560 


Thr Ser Leu Ala Phe Phe Lys Arg Asn Glu Leu Glu Asp Ile Phe Lys 
                565                 570                 575     


Lys Ser Phe Leu Ile Gly Gly Asn Asn Pro His Pro Phe Leu Ser Arg 
            580                 585                 590         


Ile Lys Ile Asn Thr Met Pro Ser Leu Phe Asp Phe Tyr Leu Ala Tyr 
        595                 600                 605             


Met Arg Glu Arg Leu Asn Tyr Trp Glu Lys Ile Lys Leu Lys Leu Leu 
    610                 615                 620                 


Lys Gly His Ile Asn Val Ser Cys His Pro Leu Arg Lys Leu Asn His 
625                 630                 635                 640 


Gly Lys Pro Val Asp Gln Asp Asn Lys Lys Asp Glu Gln Pro Ile Phe 
                645                 650                 655     


Leu Pro Arg Gly Ile Phe Asn Asp Val Ile Lys Asn Cys Leu Gln Lys 
            660                 665                 670         


Thr Lys Leu Gly Ile Tyr Leu Lys Asp Gln Gly Val Glu Thr Arg Ser 
        675                 680                 685             


Trp Asn Val Ala Tyr Gln Ile Leu Lys Phe His Glu Ile Ile Asn Asp 
    690                 695                 700                 


Asp Asp Ile Gln Glu Phe Tyr Lys Gln Pro Arg Lys Tyr Ala Ile Leu 
705                 710                 715                 720 


Asp Glu Asn His Tyr Leu Thr Leu Glu Glu Arg Thr Asp Arg Leu Lys 
                725                 730                 735     


Asp Leu Lys Pro Glu Cys Ile Glu Val Ser Lys Ala Asn Asp Ile Leu 
            740                 745                 750         


Glu Lys Glu Asp Tyr Leu Leu Arg Lys Ser Tyr Asn Gln Val Cys Asp 
        755                 760                 765             


Asn Glu Ser Ala Ile Arg Leu Tyr Gln Val Gln Asp Ile Leu Leu Phe 
    770                 775                 780                 


Met Ile Ala Gln Arg Leu Cys Asn Glu Ile Ile Leu Gly Asp Lys Gln 
785                 790                 795                 800 


Glu Lys Lys Glu Lys Val Glu Thr Ser Phe Ser Leu Thr Leu Lys Asn 
                805                 810                 815     


Leu Ser Lys Lys Phe Asp Gln Pro Val His Phe Glu Ile Lys Met Asn 
            820                 825                 830         


Asn Val Asn Leu Phe Ser Asp Thr Asp Ile Pro Val Lys Asn Phe Gly 
        835                 840                 845             


Lys Met Leu Arg Leu Lys Lys Asp Ala Arg Phe Ile Ser Tyr Asp Lys 
    850                 855                 860                 


Leu Phe Lys Gly Gln Lys Gln Asn Ile Asn Tyr Asn Asp Tyr Cys Lys 
865                 870                 875                 880 


Glu Glu Glu Tyr Phe Asp Ile Cys Arg Ile Gln Met Val Lys Leu Cys 
                885                 890                 895     


His Glu Leu Glu Glu Lys Leu Leu Glu Glu Gly Ile Ile Thr Glu Ser 
            900                 905                 910         


Pro Asn Ser Gly Tyr Tyr Pro Phe Ala Asp Leu Val Gln Ile Ile Ile 
        915                 920                 925             


Asn Gln Gly Val Val Ile Ser Ser Ser Asp Val Lys Phe Ile Leu Glu 
    930                 935                 940                 


Ala Arg Asn Met Phe Leu His Asn Glu Tyr Lys Gln Cys Cys Val Asn 
945                 950                 955                 960 


Ser Ile Asn Ser Ile Asp Ser Phe Ile Ala Glu Lys Val His Asn Leu 
                965                 970                 975     


Phe Lys Gln Lys Met Asp Asn Ile Leu Gly Gln Leu Glu Ser Ile Lys 
            980                 985                 990         


Ser Ser 
        


<210>  2650
<211>  1131
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2650

Met Glu Lys Thr Ile Glu Asn Gln Thr Gln Ser Lys Arg Thr Leu Asn 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Asp Glu Glu Lys Ile Thr Thr Ser Phe Leu Val Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Arg Gln Ser Leu Val Tyr Ser Asn Leu Thr 
65                  70                  75                  80  


Arg Tyr Met His Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Asp 
                85                  90                  95      


Asp Glu Arg Asp Lys Ala Glu Asn Tyr Gly Lys Asp Phe Gly Asn Leu 
            100                 105                 110         


Thr Asp Thr Leu Lys Glu Ile Phe Lys Glu Leu Asn Glu Phe Arg Asn 
        115                 120                 125             


Asp Tyr Ser His Tyr Tyr Ser Thr Glu Lys Lys Asp Lys Arg Lys Thr 
    130                 135                 140                 


Ile Val Ser Asp Lys Leu Lys Asn Phe Leu Asn Ile Asn Tyr Thr Arg 
145                 150                 155                 160 


Ala Ile Lys Tyr Thr Lys Ser Arg Phe Ile Asn Val Phe Ser Asp Asn 
                165                 170                 175     


Asn Phe Cys Leu Ala Glu Glu Ala Lys His Val Glu Asn Asp Asn Thr 
            180                 185                 190         


Ile Thr Gln Asp Gly Ile Val Phe Phe Thr Ser Met Phe Leu Asp Arg 
        195                 200                 205             


Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile Ile Gly Leu Lys Gly Thr 
    210                 215                 220                 


Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Thr Leu Met Ala Phe Cys 
225                 230                 235                 240 


Val Asn Leu Pro His Asp Lys Phe Val Ser Glu Asn Ser Glu Gln Gln 
                245                 250                 255     


Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu 
            260                 265                 270         


Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln His Phe Leu Pro Lys Leu 
        275                 280                 285             


Asp Asp Glu Gln Ile Asp Asn Val Leu Glu Asn Ser Val Pro Tyr Thr 
    290                 295                 300                 


Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn Ile Thr Lys Lys Val Arg 
305                 310                 315                 320 


Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu Lys Phe Ile Asp Gln Lys 
                325                 330                 335     


Lys Leu Phe Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val 
            340                 345                 350         


Leu Asp Glu Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Lys Arg Thr 
        355                 360                 365             


Val Thr Glu Asn Thr Lys Ala Phe Gly Met Leu Gln Asp Leu Asn Asp 
    370                 375                 380                 


Glu Glu Asn Val Leu Asn Lys Ile Asn Thr Gly Glu Ser Lys Ala Lys 
385                 390                 395                 400 


Phe Asp Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Thr Lys Asn 
            420                 425                 430         


Thr Asp Asn Lys Ile Lys Ser Asn Leu Leu Gln Pro Leu Pro Glu Ala 
        435                 440                 445             


Phe Leu Ser Ile Asn Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
    450                 455                 460                 


Glu Gln Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn 
465                 470                 475                 480 


Asn Ser Lys Ile Leu Asn Lys Glu Phe Ile Lys Ala Ile Lys Leu Lys 
                485                 490                 495     


Leu Asn Asp Leu Asp Val Phe Tyr Lys Arg Ser Gln Gly Arg Lys Gln 
            500                 505                 510         


Lys His Ala Tyr Leu Thr Lys Asp Lys Lys Tyr Asp Asn Glu Lys Ile 
        515                 520                 525             


Asn Glu Leu Lys Asn Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu 
    530                 535                 540                 


Tyr Asn Leu Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp 
545                 550                 555                 560 


Leu Asn Ile Ala Asp Val Gln Ala Lys Asn Ala Ile Ser Asp Arg Ile 
                565                 570                 575     


Lys Leu Met Lys Arg Asp Cys Ile Asn Arg Leu Lys Ser Met Lys Lys 
            580                 585                 590         


Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp 
        595                 600                 605             


Ile Val Asp Met Ile Ile Asp Glu Glu Lys Lys Lys Lys Ile Thr Ser 
    610                 615                 620                 


Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Lys 
625                 630                 635                 640 


Glu Lys Lys Glu Leu Phe Ile Leu Ile Cys Asn Asn Glu Leu Lys Leu 
                645                 650                 655     


Asn Asp Asp Asp Gly His Pro Phe Phe Lys Asn Ile Asn Phe Ser Asn 
            660                 665                 670         


Tyr Lys Tyr Thr Ser Glu Ile Tyr Gln Lys Tyr Leu Glu Glu Lys Gly 
        675                 680                 685             


His Lys Met Val Lys Glu Tyr Asn Pro Arg Lys Glu Asn Tyr Val Glu 
    690                 695                 700                 


Lys Asp Lys Ser Trp Leu Glu Ile Asn Phe Tyr Lys Lys Glu Trp Asn 
705                 710                 715                 720 


Glu Asn Ala Lys Lys Asp Leu Thr Val Val Lys Leu Pro Asp Asp Lys 
                725                 730                 735     


Ser Lys Ile Pro Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser 
            740                 745                 750         


Phe Glu Asn Trp Phe Lys Tyr Val Thr Asn Gly Lys Glu Thr Thr Asp 
        755                 760                 765             


Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp Glu Thr Leu 
    770                 775                 780                 


Lys Glu Leu Leu Lys Lys Glu Leu Ser Lys Asn Asn Ile Glu Phe Lys 
785                 790                 795                 800 


Glu Glu Asp Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Asp Lys Cys 
                805                 810                 815     


Arg Asn Asp Lys Thr Gln Lys Phe Tyr Ser Ala Glu Arg Glu Tyr Thr 
            820                 825                 830         


Phe Glu Glu Glu Lys Leu Asn Phe His Ile Asn Thr Lys Ser Lys Phe 
        835                 840                 845             


Glu Glu Tyr Ile Asn Pro Glu Phe Ala Glu Lys Val Phe Arg Leu Lys 
    850                 855                 860                 


Asn Gln Asn Arg Glu Lys Asp Asn Ile Ser Gly Arg Arg Leu Pro Pro 
865                 870                 875                 880 


Leu Lys Met Lys Glu Val Thr Lys Asn Met Val Lys Arg Ile Gly Asn 
                885                 890                 895     


Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Leu Met Leu 
            900                 905                 910         


Leu Met Phe Glu Lys Leu Val Asp Asn Asn Leu Lys Leu Lys Leu Glu 
        915                 920                 925             


Asn Val Asp Lys Leu Leu Asn Glu Ser Ile Glu Ile Asn Gln Ser Ile 
    930                 935                 940                 


Ser Gly Lys Leu Ser Phe Asp Asp Ser Gly Asp Asn Glu Asn Lys Lys 
945                 950                 955                 960 


Asp Arg Ala Ile Ile Cys Arg Asn Ile Thr Glu Thr Arg Lys Arg Lys 
                965                 970                 975     


Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Glu Glu Glu  Asn Ile Pro Ile Glu  Lys Ile Lys 
        995                 1000                 1005             


Ile Glu  Leu Asp Thr Tyr Ser  Lys Ala Lys Asp Val  Val Phe Asp 
    1010                 1015                 1020             


Leu Ile  Phe Asp Leu Glu Arg  Ala Ile Ile Asn Lys  Asp Glu Asn 
    1025                 1030                 1035             


Arg Ile  Lys Glu Leu Asn Lys  Asp Lys Asn Gly Val  Ile Gln Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Phe Trp Leu  Leu Glu Lys 
    1055                 1060                 1065             


Asn Leu  Ile Thr Glu Gln Glu  Phe Thr Phe Met Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Ile  Phe Ser His Asn Gln  Phe Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Leu Phe  Ile Lys Asn Trp Asn  Glu Asn Glu Phe Ala  Lys Gln Ile 
    1100                 1105                 1110             


Leu Asn  Val Tyr Asn Gln Lys  Asn Asn Asn Leu Ile  Lys Ser Ile 
    1115                 1120                 1125             


Lys Asp  Ile 
    1130     


<210>  2651
<211>  994
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2651

Met Asp Ser Lys Tyr Ile Leu Gly Ser Tyr Leu Asn Met Ala Asn Asp 
1               5                   10                  15      


Asn Phe Ile Asn Thr Ile His Leu Leu Ala Lys Lys Leu Lys Thr Pro 
            20                  25                  30          


Lys Gly Glu Asp Gln Asn Leu Asp Gln Val Val Ser Tyr Ile Thr Arg 
        35                  40                  45              


Ile Phe Asp Asn Ser Asn Gln Val Pro Glu Thr Glu Gln Ile Val Glu 
    50                  55                  60                  


Phe Tyr Phe Pro Trp Leu Glu Ala Leu Lys Asn Ala Asn Gly Phe Gly 
65                  70                  75                  80  


Lys Ser Glu Leu Pro Glu Leu Lys Ile Phe Tyr Lys Asp Val Leu Cys 
                85                  90                  95      


Ser Phe Ala Glu Asn Leu Lys Asp Leu Arg Asn Asn Tyr Thr His Tyr 
            100                 105                 110         


Ile His Lys Thr Ile Ser Tyr His Pro Ile Ile Tyr Lys Lys Glu Gly 
        115                 120                 125             


Asn Thr Leu Gln Ser Ser Leu Pro Lys Ala Leu Leu Gln Ile Tyr Asp 
    130                 135                 140                 


Ala Ser Ile Lys Leu Ala Lys Glu Arg Phe Ser Ala Asp Glu Asn Ala 
145                 150                 155                 160 


Val Thr His Leu Arg Arg Tyr Lys Met Val Gly Lys Lys Val Val Arg 
                165                 170                 175     


Lys Thr Glu Ala Asp His Phe Leu Tyr Leu Leu Glu Lys Asp His Leu 
            180                 185                 190         


Leu Thr Glu Lys Gly Ile Ala Phe Phe Thr Ser Leu Phe Leu Asn Arg 
        195                 200                 205             


Lys Tyr Gly Tyr Leu Met Leu Lys Gln Leu Lys Gly Phe Lys Gln Gly 
    210                 215                 220                 


Gly Thr Leu Ala Tyr Arg Leu Thr Leu Glu Thr Phe Leu Ala Tyr Ser 
225                 230                 235                 240 


Asn Ile Lys Pro Val Glu Arg Leu Lys Ala Asp Lys Tyr Ser Asp Val 
                245                 250                 255     


Ala Phe Ile Met Asp Leu Leu Gly Glu Ile Ser Lys Ile Pro Lys Glu 
            260                 265                 270         


Leu Tyr His Ile Leu Pro Glu Thr Tyr Ile Leu Gln Tyr Lys Asn Lys 
        275                 280                 285             


Leu His Ile Glu Leu Asn Glu Asp Ile Ser Leu Glu Ala Tyr Cys Ser 
    290                 295                 300                 


Arg Gly Arg Asn Arg Phe Asp Gln Leu Ala Leu Thr Tyr Leu Asp Arg 
305                 310                 315                 320 


Leu Glu Asp Phe Lys Gln Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr 
                325                 330                 335     


Ile His Asn Gly Tyr Met Lys Val Arg Ile Asp Gly Thr Glu Gln Glu 
            340                 345                 350         


Arg Tyr Leu Ser Glu Lys Met Tyr Gly Cys Cys Lys Asn Ile Tyr Arg 
        355                 360                 365             


Asp Leu Ser Ala Ile Val Ala Lys Gln Tyr Asn Ile Lys Val Lys Asp 
    370                 375                 380                 


Ser Thr Glu Thr Ser Tyr Met Leu Pro Asn Asp Phe Gln Pro His Val 
385                 390                 395                 400 


Ile Arg Ala Tyr Pro His Tyr Val Ile Asn Asn Asn Asn Ile Gly Ile 
                405                 410                 415     


Arg Leu Leu Asp Glu Gly Glu Ser Gly Phe Pro Ile Leu Glu Asn Arg 
            420                 425                 430         


Gly Thr Lys Asn Val Val Pro His Phe Trp Met Ser Lys Tyr Asp Leu 
        435                 440                 445             


Pro Ala Leu Leu Phe Tyr Ala Tyr Leu Arg Ser Asp Ser Arg Phe Ala 
    450                 455                 460                 


Ser Lys Cys Lys Lys Thr Ile Asp Glu Ile Leu Arg Gly Tyr Leu Ser 
465                 470                 475                 480 


Lys Ser Lys Asp Lys Lys Pro Lys Gln Ala Glu Lys Val Ser Val Leu 
                485                 490                 495     


Met Leu Arg Arg Ile Asp Lys Ala Ile Ile Trp Thr Gln Thr Lys Leu 
            500                 505                 510         


Asn Glu Ala Glu Lys Gln Arg Asp Asn Lys Lys Ser Phe Lys Ile Gly 
        515                 520                 525             


Glu Lys Ala Asp Ile Leu Ala His Asp Met Leu Trp Leu Gln Pro Ala 
    530                 535                 540                 


Lys Glu Ser Lys Asp Lys Val Ser Gly Ala Asn Phe Arg Ala Leu Gln 
545                 550                 555                 560 


Thr Ser Leu Ala Phe Phe Lys Arg Asn Glu Leu Glu Asp Ile Phe Lys 
                565                 570                 575     


Lys Ser Phe Leu Ile Gly Gly Asn Asn Pro His Pro Phe Leu Ser Arg 
            580                 585                 590         


Ile Lys Ile Asn Thr Met Pro Ser Leu Phe Asp Phe Tyr Leu Ala Tyr 
        595                 600                 605             


Met Arg Glu Arg Leu Asn Tyr Trp Glu Lys Ile Lys Leu Lys Leu Leu 
    610                 615                 620                 


Lys Gly His Ile Asn Val Ser Cys His Pro Leu Arg Lys Leu Asn His 
625                 630                 635                 640 


Gly Lys Pro Val Asp Gln Asp Asn Lys Lys Asp Glu Gln Pro Ile Phe 
                645                 650                 655     


Leu Pro Arg Gly Ile Phe Asn Asp Val Ile Lys Asn Cys Leu Gln Lys 
            660                 665                 670         


Thr Lys Leu Gly Ile Tyr Leu Lys Asp Gln Gly Val Glu Thr Arg Ser 
        675                 680                 685             


Trp Asn Val Ala Tyr Gln Ile Leu Lys Phe His Glu Ile Ile Asn Asp 
    690                 695                 700                 


Asp Asp Ile Gln Glu Phe Tyr Lys Gln Pro Arg Lys Tyr Ala Ile Leu 
705                 710                 715                 720 


Asp Glu Asn His Tyr Leu Thr Leu Glu Glu Arg Thr Asp Arg Leu Lys 
                725                 730                 735     


Asp Leu Lys Pro Glu Cys Ile Glu Val Ser Lys Ala Asn Asp Ile Leu 
            740                 745                 750         


Glu Lys Glu Asp Tyr Leu Leu Arg Lys Ser Tyr Asn Gln Val Cys Asp 
        755                 760                 765             


Asn Glu Ser Ala Ile Arg Leu Tyr Gln Val Gln Asp Ile Leu Leu Phe 
    770                 775                 780                 


Met Ile Ala Gln Arg Leu Cys Asn Glu Ile Ile Leu Gly Asp Lys Gln 
785                 790                 795                 800 


Glu Lys Lys Glu Lys Val Glu Thr Ser Phe Ser Leu Thr Leu Lys Asn 
                805                 810                 815     


Leu Ser Lys Lys Phe Asp Gln Pro Val His Phe Glu Ile Lys Met Asn 
            820                 825                 830         


Asn Val Asn Leu Phe Ser Asp Thr Asp Ile Pro Val Lys Asn Phe Gly 
        835                 840                 845             


Lys Met Leu Arg Leu Lys Lys Asp Ala Arg Phe Ile Ser Tyr Asp Lys 
    850                 855                 860                 


Leu Phe Lys Gly Gln Lys Gln Asn Ile Asn Tyr Asn Asp Tyr Cys Lys 
865                 870                 875                 880 


Glu Glu Glu Tyr Phe Asp Ile Cys Arg Ile Gln Met Val Lys Leu Cys 
                885                 890                 895     


His Glu Leu Glu Glu Lys Leu Leu Glu Glu Gly Ile Ile Thr Glu Ser 
            900                 905                 910         


Pro Asn Ser Gly Tyr Tyr Pro Phe Ala Asp Leu Val Gln Ile Ile Ile 
        915                 920                 925             


Asn Gln Gly Val Val Ile Ser Ser Ser Asp Val Lys Phe Ile Leu Glu 
    930                 935                 940                 


Ala Arg Asn Met Phe Leu His Asn Glu Tyr Lys Gln Cys Cys Val Asn 
945                 950                 955                 960 


Ser Ile Asn Ser Ile Asp Ser Phe Ile Ala Glu Lys Val His Asn Leu 
                965                 970                 975     


Phe Lys Gln Lys Met Asp Asn Ile Leu Gly Gln Leu Glu Ser Ile Lys 
            980                 985                 990         


Ser Ser 
        


<210>  2652
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2652

Leu Gln Lys Gln Asp Lys Leu Phe Val Asp Arg Lys Lys Asn Ala Ile 
1               5                   10                  15      


Phe Ala Phe Pro Lys Tyr Ile Thr Ile Met Glu Asn Lys Glu Lys Pro 
            20                  25                  30          


Glu Pro Ile Tyr Tyr Glu Leu Thr Asp Lys His Phe Trp Ala Ala Phe 
        35                  40                  45              


Leu Asn Leu Ala Arg His Asn Val Tyr Thr Thr Ile Asn His Ile Asn 
    50                  55                  60                  


Arg Arg Leu Glu Ile Ala Glu Leu Lys Asp Asp Gly Tyr Met Met Gly 
65                  70                  75                  80  


Ile Lys Gly Ser Trp Asn Glu Gln Ala Lys Lys Leu Asp Lys Lys Val 
                85                  90                  95      


Arg Leu Arg Asp Leu Ile Met Lys His Phe Pro Phe Leu Glu Ala Ala 
            100                 105                 110         


Ala Tyr Glu Ile Thr Asn Ser Lys Ser Pro Asn Asn Lys Glu Gln Arg 
        115                 120                 125             


Glu Lys Lys Gln Ser Glu Ala Leu Ser Leu Asn Asn Leu Lys Asn Val 
    130                 135                 140                 


Leu Phe Ile Phe Leu Glu Lys Leu Gln Val Leu Arg Asn Tyr Tyr Ser 
145                 150                 155                 160 


His Tyr Lys Tyr Ser Glu Glu Ser Pro Lys Pro Ile Phe Glu Thr Ser 
                165                 170                 175     


Leu Leu Lys Asn Met Tyr Lys Val Phe Asp Ala Asn Val Arg Leu Val 
            180                 185                 190         


Lys Arg Asp Tyr Met His His Glu Asn Ile Asp Met Gln Arg Asp Phe 
        195                 200                 205             


Thr His Leu Asn Arg Lys Lys Gln Val Gly Arg Thr Lys Asn Ile Ile 
    210                 215                 220                 


Asp Ser Pro Asn Phe His Tyr His Phe Ala Asp Lys Glu Gly Asn Met 
225                 230                 235                 240 


Thr Ile Ala Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Asp Lys Lys 
                245                 250                 255     


Asp Ala Ile Trp Met Gln Lys Lys Leu Lys Gly Phe Lys Asp Gly Arg 
            260                 265                 270         


Asn Leu Arg Glu Gln Met Thr Asn Glu Val Phe Cys Arg Ser Arg Ile 
        275                 280                 285             


Ser Leu Pro Lys Leu Lys Leu Glu Asn Val Gln Thr Lys Asp Trp Met 
    290                 295                 300                 


Gln Leu Asp Met Leu Asn Glu Leu Val Arg Cys Pro Lys Ser Leu Tyr 
305                 310                 315                 320 


Glu Arg Leu Arg Glu Lys Asp Arg Glu Ser Phe Lys Val Pro Phe Asp 
                325                 330                 335     


Ile Phe Ser Asp Asp Tyr Asp Ala Glu Glu Glu Pro Phe Lys Asn Thr 
            340                 345                 350         


Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe 
        355                 360                 365             


Asp Leu Asn Glu Ile Phe Glu Gln Leu Arg Phe Gln Ile Asp Leu Gly 
    370                 375                 380                 


Thr Tyr His Phe Ser Ile Tyr Asn Lys Leu Ile Gly Asp Glu Asp Glu 
385                 390                 395                 400 


Val Arg His Leu Thr His His Leu Tyr Gly Phe Ala Arg Ile Gln Asp 
                405                 410                 415     


Phe Ala Pro Gln Asn Gln Pro Glu Glu Trp Arg Lys Leu Val Lys Asp 
            420                 425                 430         


Leu Asp His Phe Glu Thr Ser Gln Lys Pro Tyr Ile Ser Lys Thr Ala 
        435                 440                 445             


Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Lys Phe Cys Ser 
    450                 455                 460                 


Thr His Asn Asn Leu Phe Pro Ser Leu Lys Arg Glu Lys Thr Cys Asn 
465                 470                 475                 480 


Gly Arg Ser Lys Phe Asn Leu Gly Thr Gln Phe Thr Ala Glu Ala Phe 
                485                 490                 495     


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu 
            500                 505                 510         


Thr Lys Asp Tyr Ser Arg Lys Glu Ser Ala Asp Lys Val Glu Gly Ile 
        515                 520                 525             


Ile Arg Lys Glu Ile Ser Asn Ile Tyr Ala Ile Tyr Asp Ala Phe Ala 
    530                 535                 540                 


Asn Asn Glu Ile Asn Ser Ile Ala Asp Leu Thr Cys Arg Leu Gln Lys 
545                 550                 555                 560 


Thr Asn Ile Leu Gln Gly His Leu Pro Lys Gln Met Ile Ser Ile Leu 
                565                 570                 575     


Glu Gly Arg Gln Lys Asp Met Glu Lys Glu Ala Glu Arg Lys Ile Gly 
            580                 585                 590         


Glu Met Ile Asp Asp Thr Gln Arg Arg Leu Asp Leu Leu Cys Lys Gln 
        595                 600                 605             


Thr Asn Gln Lys Ile Arg Ile Gly Lys Arg Asn Ala Gly Leu Leu Lys 
    610                 615                 620                 


Ser Gly Lys Ile Ala Asp Trp Leu Val Ser Asp Met Met Arg Phe Gln 
625                 630                 635                 640 


Pro Val Gln Lys Asp Thr Asn Asn Ala Pro Ile Asn Asn Ser Lys Ala 
                645                 650                 655     


Asn Ser Thr Glu Tyr Arg Met Leu Gln His Ala Leu Ala Leu Phe Gly 
            660                 665                 670         


Ser Glu Ser Ser Arg Leu Lys Ala Tyr Phe Arg Gln Met Asn Leu Val 
        675                 680                 685             


Gly Asn Ala Asn Pro His Pro Phe Leu Ala Glu Thr Gln Trp Glu His 
    690                 695                 700                 


Gln Thr Asn Ile Leu Ser Phe Tyr Arg Asn Tyr Leu Glu Ala Arg Lys 
705                 710                 715                 720 


Lys Tyr Leu Lys Gly Leu Lys Pro Gln Asn Trp Lys Gln Tyr Gln His 
                725                 730                 735     


Phe Leu Ile Leu Lys Val Gln Lys Thr Asn Arg Asn Thr Leu Val Thr 
            740                 745                 750         


Gly Trp Lys Asn Ser Phe Asn Leu Pro Arg Gly Ile Phe Thr Gln Pro 
        755                 760                 765             


Ile Arg Glu Trp Phe Glu Lys His Asn Asn Ser Lys Arg Ile Tyr Asp 
    770                 775                 780                 


Gln Ile Leu Ser Phe Asp Arg Val Gly Phe Val Ala Lys Ala Ile Pro 
785                 790                 795                 800 


Leu Tyr Phe Ala Glu Glu Tyr Lys Asp Asn Val Gln Pro Phe Tyr Asp 
                805                 810                 815     


Tyr Pro Phe Asn Ile Gly Asn Lys Leu Lys Pro Gln Lys Gly Gln Phe 
            820                 825                 830         


Leu Asp Lys Lys Glu Arg Val Glu Leu Trp Gln Lys Asn Lys Glu Leu 
        835                 840                 845             


Phe Lys Asn Tyr Pro Ser Glu Lys Lys Lys Thr Asp Leu Ala Tyr Leu 
    850                 855                 860                 


Asp Phe Leu Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys 
865                 870                 875                 880 


Asn Gln Asp Ile Val Thr Trp Leu Met Phe Lys Glu Leu Phe Asn Met 
                885                 890                 895     


Ala Thr Val Glu Gly Leu Lys Ile Gly Glu Ile His Leu Arg Asp Ile 
            900                 905                 910         


Asp Thr Asn Thr Ala Lys Ala Glu Ser Asn Asn Ile Leu Asn Arg Ile 
        915                 920                 925             


Met Pro Met Lys Leu Pro Val Lys Thr Tyr Glu Thr Asp Asn Lys Gly 
    930                 935                 940                 


Asn Ile Leu Lys Glu Arg Pro Leu Ala Thr Phe Tyr Ile Glu Glu Thr 
945                 950                 955                 960 


Glu Thr Lys Val Leu Lys Gln Gly Asn Phe Lys Val Leu Ala Lys Asp 
                965                 970                 975     


Arg Arg Leu Asn Gly Leu Leu Ser Phe Ala Glu Thr Thr Asp Ile Asp 
            980                 985                 990         


Leu Glu Lys Asn Pro Ile Thr Lys  Leu Ser Val Asp His  Glu Leu Ile 
        995                 1000                 1005             


Lys Tyr  Gln Thr Thr Arg Ile  Ser Ile Phe Glu Met  Thr Leu Gly 
    1010                 1015                 1020             


Leu Glu  Lys Lys Leu Ile Asp  Lys Tyr Ser Thr Leu  Pro Thr Asp 
    1025                 1030                 1035             


Ser Phe  Arg Asn Met Leu Glu  Arg Trp Leu Gln Cys  Lys Ala Asn 
    1040                 1045                 1050             


Arg Pro  Glu Leu Lys Asn Tyr  Val Asn Ser Leu Ile  Ala Val Arg 
    1055                 1060                 1065             


Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met Tyr Asp  Ala Thr Leu 
    1070                 1075                 1080             


Phe Ala  Glu Val Lys Lys Phe  Thr Leu Phe Pro Ser  Val Asp Thr 
    1085                 1090                 1095             


Lys Lys  Ile Glu Leu Asn Ile  Ala Pro Gln Leu Leu  Glu Ile Val 
    1100                 1105                 1110             


Gly Lys  Ala Ile Lys Glu Ile  Glu Lys Ser Glu Asn  Lys Asn 
    1115                 1120                 1125         


<210>  2653
<211>  1131
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2653

Met Glu Lys Thr Ile Glu Asn Gln Thr Gln Ser Lys Arg Thr Leu Asn 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Asp Glu Glu Lys Ile Thr Thr Ser Phe Leu Val Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Arg Gln Ser Leu Val Tyr Ser Asn Leu Thr 
65                  70                  75                  80  


Arg Tyr Met His Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Asp 
                85                  90                  95      


Asp Glu Arg Asp Lys Ala Glu Asn Tyr Gly Lys Asp Phe Gly Asn Leu 
            100                 105                 110         


Thr Asp Thr Leu Lys Glu Ile Phe Lys Glu Leu Asn Glu Phe Arg Asn 
        115                 120                 125             


Asp Tyr Ser His Tyr Tyr Ser Thr Glu Lys Lys Asp Lys Arg Lys Thr 
    130                 135                 140                 


Ile Val Ser Asp Lys Leu Lys Asn Phe Leu Asn Ile Asn Tyr Thr Arg 
145                 150                 155                 160 


Ala Ile Lys Tyr Thr Lys Ser Arg Phe Ile Asn Val Phe Ser Asp Asn 
                165                 170                 175     


Asn Phe Cys Leu Ala Glu Glu Ala Lys His Val Glu Asn Asp Asn Thr 
            180                 185                 190         


Ile Thr Gln Asp Gly Ile Val Phe Phe Thr Ser Met Phe Leu Asp Arg 
        195                 200                 205             


Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile Ile Gly Leu Lys Gly Thr 
    210                 215                 220                 


Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Thr Leu Met Ala Phe Cys 
225                 230                 235                 240 


Val Asn Leu Pro His Asp Lys Phe Val Ser Glu Asn Ser Glu Gln Gln 
                245                 250                 255     


Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu 
            260                 265                 270         


Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln His Phe Leu Pro Lys Leu 
        275                 280                 285             


Asp Asp Glu Gln Ile Asp Asn Val Leu Glu Asn Ser Val Pro Tyr Thr 
    290                 295                 300                 


Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn Ile Thr Lys Lys Val Arg 
305                 310                 315                 320 


Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu Lys Phe Ile Asp Gln Lys 
                325                 330                 335     


Lys Leu Phe Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val 
            340                 345                 350         


Leu Asp Glu Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Lys Arg Thr 
        355                 360                 365             


Val Thr Glu Asn Thr Lys Ala Phe Gly Met Leu Gln Asp Leu Asn Asp 
    370                 375                 380                 


Glu Glu Asn Val Leu Asn Lys Ile Asn Thr Gly Glu Ser Lys Ala Lys 
385                 390                 395                 400 


Phe Asp Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Thr Lys Asn 
            420                 425                 430         


Thr Asp Asn Lys Ile Lys Ser Asn Leu Leu Gln Pro Leu Pro Glu Ala 
        435                 440                 445             


Phe Leu Ser Ile Asn Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
    450                 455                 460                 


Glu Gln Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn 
465                 470                 475                 480 


Asn Ser Lys Ile Leu Asn Lys Glu Phe Ile Lys Ala Ile Lys Leu Lys 
                485                 490                 495     


Leu Asn Asp Leu Asp Val Phe Tyr Lys Arg Ser Gln Gly Arg Lys Gln 
            500                 505                 510         


Lys His Ala Tyr Leu Thr Lys Asp Lys Lys Tyr Asp Asn Glu Lys Ile 
        515                 520                 525             


Asn Glu Leu Lys Asn Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu 
    530                 535                 540                 


Tyr Asn Leu Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp 
545                 550                 555                 560 


Leu Asn Ile Ala Asp Val Gln Ala Lys Asn Ala Ile Ser Asp Arg Ile 
                565                 570                 575     


Lys Leu Met Lys Arg Asp Cys Ile Asn Arg Leu Lys Ser Met Lys Lys 
            580                 585                 590         


Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp 
        595                 600                 605             


Ile Val Asp Met Ile Ile Asp Glu Glu Lys Lys Lys Lys Ile Thr Ser 
    610                 615                 620                 


Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Lys 
625                 630                 635                 640 


Glu Lys Lys Glu Leu Phe Ile Leu Ile Cys Asn Asn Glu Leu Lys Leu 
                645                 650                 655     


Asn Asp Asp Asp Gly His Pro Phe Phe Lys Asn Ile Asn Phe Ser Asn 
            660                 665                 670         


Tyr Lys Tyr Thr Ser Glu Ile Tyr Gln Lys Tyr Leu Glu Glu Lys Gly 
        675                 680                 685             


His Lys Met Val Lys Glu Tyr Asn Pro Arg Lys Glu Asn Tyr Val Glu 
    690                 695                 700                 


Lys Asp Lys Ser Trp Leu Glu Ile Asn Phe Tyr Lys Lys Glu Trp Asn 
705                 710                 715                 720 


Glu Asn Ala Lys Lys Asp Leu Thr Val Val Lys Leu Pro Asp Asp Lys 
                725                 730                 735     


Ser Lys Ile Pro Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser 
            740                 745                 750         


Phe Glu Asn Trp Phe Lys Tyr Val Thr Asn Gly Lys Glu Thr Thr Asp 
        755                 760                 765             


Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp Glu Thr Leu 
    770                 775                 780                 


Lys Glu Leu Leu Lys Lys Glu Leu Ser Lys Asn Asn Ile Glu Phe Lys 
785                 790                 795                 800 


Glu Glu Asp Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Asp Lys Cys 
                805                 810                 815     


Arg Asn Asp Lys Thr Gln Lys Phe Tyr Ser Ala Glu Arg Glu Tyr Thr 
            820                 825                 830         


Phe Glu Glu Glu Lys Leu Asn Phe His Ile Asn Thr Lys Ser Lys Phe 
        835                 840                 845             


Glu Glu Tyr Ile Asn Pro Glu Phe Ala Glu Lys Val Phe Arg Leu Lys 
    850                 855                 860                 


Asn Gln Asn Arg Glu Lys Asp Asn Ile Ser Gly Arg Arg Leu Pro Pro 
865                 870                 875                 880 


Leu Lys Met Lys Glu Val Thr Lys Asn Met Val Lys Arg Ile Gly Asn 
                885                 890                 895     


Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Leu Met Leu 
            900                 905                 910         


Leu Met Phe Glu Lys Leu Val Asp Asn Asn Leu Lys Leu Lys Leu Glu 
        915                 920                 925             


Asn Val Asp Lys Leu Leu Asn Glu Ser Ile Glu Ile Asn Gln Ser Ile 
    930                 935                 940                 


Ser Gly Lys Leu Ser Phe Asp Asp Ser Gly Asp Asn Glu Asn Lys Lys 
945                 950                 955                 960 


Asp Arg Ala Ile Ile Cys Arg Asn Ile Thr Glu Thr Arg Lys Arg Lys 
                965                 970                 975     


Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Glu Glu Glu  Asn Ile Pro Ile Glu  Lys Ile Lys 
        995                 1000                 1005             


Ile Glu  Leu Asp Thr Tyr Ser  Lys Ala Lys Asp Val  Val Phe Asp 
    1010                 1015                 1020             


Leu Ile  Phe Asp Leu Glu Arg  Ala Ile Ile Asn Lys  Asp Glu Asn 
    1025                 1030                 1035             


Arg Ile  Lys Glu Leu Asn Lys  Asp Lys Asn Gly Val  Ile Gln Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Phe Trp Leu  Leu Glu Lys 
    1055                 1060                 1065             


Asn Leu  Ile Thr Glu Gln Glu  Phe Thr Phe Met Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Thr  Phe Ser His Asn Gln  Phe Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Leu Phe  Ile Lys Asn Trp Asn  Glu Asn Glu Phe Ala  Lys Gln Ile 
    1100                 1105                 1110             


Leu Asn  Val Tyr Asn Gln Lys  Asn Asn Asn Leu Ile  Lys Ser Ile 
    1115                 1120                 1125             


Lys Asp  Ile 
    1130     


<210>  2654
<211>  1156
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2654

Met Thr Asp Lys Val Glu Leu Asn Met Tyr Asn Ser Glu Asn Ser Trp 
1               5                   10                  15      


Lys Asn Phe Ser Thr Ser Lys Gly Thr Val Gly Pro Phe Ala Gln Lys 
            20                  25                  30          


Ala Val Arg Asn Ile Glu Leu Leu Ile Asn Gly Thr Gln Pro Glu Arg 
        35                  40                  45              


Arg Met His Tyr Phe Ala Ile Gly His Thr Phe Lys Gln Ile Asp Thr 
    50                  55                  60                  


Lys Ser Val Phe Lys Leu Thr Leu Asp Glu Glu Ser Arg Thr Ile Arg 
65                  70                  75                  80  


Pro Ala Ala Phe Met Ala Leu Gln Ser Phe Asp Ser Ser Phe Cys Arg 
                85                  90                  95      


Lys Leu Ala Glu Arg Ile Gly Ser Ile Arg Asn Ile Asn Ser His Cys 
            100                 105                 110         


Val His Asp Phe Ser Met Leu Lys Gln Glu Gly Leu Ser Glu Lys Met 
        115                 120                 125             


Ile Tyr Phe Leu Arg Glu Ser Phe Glu Leu Ala Val Cys Leu Ile Tyr 
    130                 135                 140                 


Leu Lys Glu Lys Glu Leu Asn Tyr Gln Asp Tyr Ser Val Leu Thr Asp 
145                 150                 155                 160 


Lys Asp Glu Arg Leu Val Ala Phe Leu Leu Asp Lys Phe Tyr Pro Leu 
                165                 170                 175     


Asp Lys Thr Lys Ser Ile Ala Asp Asp Lys Lys Gln Arg Phe Gln Lys 
            180                 185                 190         


Val Arg Met Gln Phe Lys Asn Leu Thr Lys Gln Glu Ala Ile Asp Ala 
        195                 200                 205             


Ile Leu Phe Thr Asn Val Asp Thr Ala Phe Glu Trp Lys Leu Tyr Asn 
    210                 215                 220                 


Leu Tyr Pro Ala Phe Ala Val Glu Thr Gly Val Tyr Leu Ser Phe Tyr 
225                 230                 235                 240 


Ala Ser Leu Phe Leu Leu Thr Met Phe Leu Tyr Lys Asn Glu Ala Glu 
                245                 250                 255     


Lys Phe Ile Ser Met Ile Arg Gly Phe Lys Lys Asn Lys Thr Pro Glu 
            260                 265                 270         


Glu Gln Ser Lys Arg Asp Ile Phe Thr Phe Phe Ser Lys Lys Phe Ser 
        275                 280                 285             


Ser Gln Asp Ile Asp Ser Glu Glu Asn Asp Leu Val Lys Phe Arg Asp 
    290                 295                 300                 


Leu Val Gln Tyr Leu Asn His Tyr Pro Val Glu Trp Asn Gln Glu Leu 
305                 310                 315                 320 


Glu Gln Thr Pro Ala His Pro Thr Met Val Lys Val Leu Ile Ser Lys 
                325                 330                 335     


Ile Ile Asp Met Glu Ile Gly Arg Cys Phe Ser Asp Tyr Ala Lys Asn 
            340                 345                 350         


Glu Arg Phe Arg Ile Phe Ala Lys Tyr Lys Leu Trp Gly Lys Arg Tyr 
        355                 360                 365             


Leu Gly Arg Glu Ala Gln Arg Glu Tyr Ile Ala Gln Ala Phe Thr Glu 
    370                 375                 380                 


Glu Glu Ile Ala Ala Phe Asn Tyr Glu Ile Asp Thr Ser Pro Glu Leu 
385                 390                 395                 400 


Lys Gly Cys Tyr Arg Lys Leu Glu Lys Leu Asn Phe Lys Lys Asn Leu 
                405                 410                 415     


Ser Glu Ile Glu Lys Lys Asn Asn Arg Ser Glu Ile Phe Lys Thr Glu 
            420                 425                 430         


Glu Arg Ile Ala Arg Ile Lys Asp Glu Pro Asn Leu Asn Val Glu Arg 
        435                 440                 445             


Leu Lys Glu Arg Ile Gln Glu Asn Tyr Arg Ser Trp Gly Arg Asn Gln 
    450                 455                 460                 


Asp Arg Phe Met Gln Phe Ala Thr Arg Phe Leu Ala Glu Thr Asn Tyr 
465                 470                 475                 480 


Phe Gly Gly Asp Val Ser Phe Lys Met Tyr Cys Tyr Phe Ser Met Asp 
                485                 490                 495     


Glu Glu Asn Ala Gly Arg Glu Glu Lys Lys Asn Ser Leu Ser Lys Glu 
            500                 505                 510         


Lys Tyr Asp Lys Leu Lys Tyr His Asn Gly Lys Leu Val Asp Tyr Leu 
        515                 520                 525             


Ile Tyr Gln Lys His Leu Gln Gln Tyr Pro Glu Trp Asp Ile Pro Phe 
    530                 535                 540                 


Val Ile Glu Asn Asn Ser Ile Gln Ile Lys Met Ser Leu Gly Asp Asp 
545                 550                 555                 560 


Pro Asn Lys Ile Val Ser Ile Gln Arg Gly Leu Met Ile Tyr Phe Leu 
                565                 570                 575     


Glu Asp Ala Leu Phe Phe Val Pro Glu Asn Arg Ile Glu Asn Ala Gly 
            580                 585                 590         


Lys His Leu Leu Glu Ala Tyr Tyr Ile Tyr His Gln Glu Ala Phe Asn 
        595                 600                 605             


Ser Asn Tyr Ser Val Leu Glu Gln Gln Ala Asp Ile Ser Pro Lys Glu 
    610                 615                 620                 


Lys Asn Gln Phe Lys Lys Leu Phe Pro Val Arg Leu Leu Tyr His Tyr 
625                 630                 635                 640 


Leu Pro Ala Val Ser Ser Asp Met Asn Glu Pro Ala Pro Leu Glu Ser 
                645                 650                 655     


Leu Leu Asn Lys Thr Ile Glu Ala Glu Lys Arg Tyr Leu Asp Leu Val 
            660                 665                 670         


Gln Lys Ala Ile Asn Glu Gly Asn Ser Glu Asp Phe Leu Lys His Asn 
        675                 680                 685             


Lys Gly Lys Gln Phe Lys Leu Gln Phe Ile Arg Lys Ala Trp Gln Leu 
    690                 695                 700                 


Leu Phe Phe Arg Glu Ile Tyr Asp Arg Arg Arg Ala Phe Ser Asn Glu 
705                 710                 715                 720 


His His Lys Ser Tyr His Ile Thr Arg Asp Glu Phe Asn Asp Phe Cys 
                725                 730                 735     


Arg Tyr Met Tyr Ala Phe Asp Glu Val Pro Glu Tyr Lys Asp Tyr Leu 
            740                 745                 750         


His Glu Leu Leu Ala Ala Lys Gly Phe Phe Asp Asn Ser Thr Phe Lys 
        755                 760                 765             


Thr Leu Phe Glu Ser Gly His Ser Leu Asp Asp Phe Tyr Lys Asn Thr 
    770                 775                 780                 


Lys Ile Ala Tyr Lys Ser Trp Val Val Lys Gln Glu Gln His Phe Val 
785                 790                 795                 800 


Pro Ala Asp Lys Tyr Thr Leu Ser Lys Tyr Asp Lys Leu Leu Asn Lys 
                805                 810                 815     


Gln Ile Leu Tyr Ile Asn Leu Ser His Phe Leu Glu Phe Leu Lys His 
            820                 825                 830         


Lys Asp Glu Pro Glu Arg Arg Asn Leu Gly Glu Met Lys Phe Lys Ala 
        835                 840                 845             


Leu Glu Asn Val Gln Tyr Leu Ile Gln Ala Tyr Tyr Tyr Ala Glu Arg 
    850                 855                 860                 


Leu Asp Pro Leu Glu Gln Lys Asn Asn Arg Asn Leu Phe Asn Glu Leu 
865                 870                 875                 880 


Arg Lys Ile Lys Leu Glu Asp Ala Leu Leu Tyr Glu Ile Ala Leu Arg 
                885                 890                 895     


Tyr Leu Lys Thr Asp Glu Arg Ile Leu Ser Asn Thr Lys Cys Leu Val 
            900                 905                 910         


Thr Ala Leu Leu Thr Gln Asp Ile Gln Phe Asp Ile Lys Asn Ala Asp 
        915                 920                 925             


Gly Asn His Leu Tyr Asn Leu Ile Val Pro Phe Lys Gln Ile Asp Ser 
    930                 935                 940                 


Leu Ala Cys Leu Leu Lys Gln Lys Glu Glu Gln Glu Gln Glu Arg Phe 
945                 950                 955                 960 


Lys Ser Ser Phe Leu Gly Asn Leu Ala Asp Tyr Leu Glu Lys Asn Lys 
                965                 970                 975     


Asn Gln Lys Glu Leu Lys Gly Ile Tyr Thr Asp Tyr Asn Ser Asn Pro 
            980                 985                 990         


Gln Asn Lys Val Leu Lys Leu Asp  Glu Leu Asn Lys Ile  Lys Asp His 
        995                 1000                 1005             


Leu Val  Thr Ser Ser Ile Lys  Phe Thr Lys Leu Asp  Met Ala Leu 
    1010                 1015                 1020             


Glu Ala  Tyr Tyr Ile Ser Ile  Pro Ile Lys Thr Gly  Asn Ala Asp 
    1025                 1030                 1035             


Phe Leu  Ser Lys Ile Glu Lys  Ala Asp Thr Gly Cys  Asn Phe Ile 
    1040                 1045                 1050             


Arg Phe  Glu Asn Thr Gly Ile  Pro Arg Lys Tyr Tyr  Asp Thr Lys 
    1055                 1060                 1065             


Ile Arg  Asn Arg Ala Phe His  Phe Gly Val Pro Asp  Lys Asn Tyr 
    1070                 1075                 1080             


Asp Gln  Ile Leu Arg Glu Ile  Glu Ser Lys Phe Ile  Val Asp Glu 
    1085                 1090                 1095             


Val Lys  Pro Ile Lys Pro Ala  Asn Phe Glu Ser Leu  Ser Val Pro 
    1100                 1105                 1110             


Leu Lys  Ala Ile Cys Cys Leu  Phe Leu Asp Glu Ile  His Gly Asp 
    1115                 1120                 1125             


Phe Phe  Asp His Gly Glu Lys  Val Asn Lys Arg Lys  His Gln Asn 
    1130                 1135                 1140             


Ala Glu  Asn Lys Tyr Phe Glu  Lys Val Ile Leu Met  Lys 
    1145                 1150                 1155     


<210>  2655
<211>  966
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2655

Met Asn Pro Glu Asn Asn Ile Val Lys Asn Tyr Ser Val Lys Glu Thr 
1               5                   10                  15      


Pro Trp Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg His Asn Val Tyr 
            20                  25                  30          


Leu Leu Ile Asn His Leu Thr Asp Lys Phe Ser Tyr Leu Lys Asn Tyr 
        35                  40                  45              


Lys Lys Leu Ser Leu Glu Lys Gln Thr Gly Thr Ser Lys Phe Glu Leu 
    50                  55                  60                  


Arg Pro Gln Pro Phe Ser Ile Leu Thr Asp Asp Glu Gln Ile Val Asn 
65                  70                  75                  80  


Glu Asn Ile Leu Thr Lys Ile Phe Asp Thr Ser Tyr Pro Gln Tyr Asp 
                85                  90                  95      


Asn Asp Arg Phe Arg Ile Tyr Lys Tyr Met Val Arg Lys His Ser Leu 
            100                 105                 110         


Pro Phe Ile Lys Asn Phe Ser Glu Thr Gly Gly Arg Asn Leu Asp Asp 
        115                 120                 125             


Asn Pro Ile Ile Asp Tyr Asp Gly Leu His Gln Tyr Ile Asn Glu Ala 
    130                 135                 140                 


Phe Ala Leu Leu Val Arg Leu Arg Asp Ser Phe Ser His Tyr Leu Ala 
145                 150                 155                 160 


Ile Asp Lys Phe Gly Asn Lys Ile Glu Asp Arg Asn Leu Thr Val Ser 
                165                 170                 175     


Thr Asn Ile His Thr Gln Val Ile Asn Leu Tyr Thr Asn Ser Pro Asn 
            180                 185                 190         


Tyr Ser Leu Glu Arg Phe Ser Ala Thr Gln Ser Asp Phe Asp Tyr Glu 
        195                 200                 205             


His Leu Ser Leu Tyr Lys Ile Phe Glu Ala Asp Asn Ile Thr Phe Thr 
    210                 215                 220                 


Glu Gln Gly Leu Tyr Phe Phe Ile Asn Leu Phe Leu Glu Arg Gly Tyr 
225                 230                 235                 240 


Gly Ile Lys Phe Leu Lys Lys Ile Arg Gly Phe Lys Asn Asp Thr Asn 
                245                 250                 255     


Pro Ala Phe Arg Ala Thr Ile Lys Thr Phe Thr Thr Tyr Ala Leu Lys 
            260                 265                 270         


Val Pro Asp Glu Arg Leu Asp Asn Asp Asp Pro Arg Met Ser Leu Leu 
        275                 280                 285             


Met Asp Val Leu Asn Glu Leu Lys Arg Cys Pro Ala Ile Leu Ser Lys 
    290                 295                 300                 


His Leu Ser Asp Gln Asp Gln Lys Lys Phe Asn Pro Gln Leu Asn Asp 
305                 310                 315                 320 


Asp Ser Lys Ala Asn Val Leu Leu Asn Ser Val Asn Tyr Asp Asp Ile 
                325                 330                 335     


Asp Asp Glu Gln Ile Asp Tyr Leu Leu Asn Ser Ile Thr Thr Phe Lys 
            340                 345                 350         


Arg His Gln Asp Arg Phe Pro Tyr Phe Ala Leu Arg Cys Ile Asp Glu 
        355                 360                 365             


Leu Asn Leu Leu Pro Asn Ile Arg Phe Gln Val Ala Leu Gly Ser Ile 
    370                 375                 380                 


Glu Arg Arg Ser Tyr Asp Lys Val Val Gly Asp Val Ile Ile Asp Arg 
385                 390                 395                 400 


Arg Ile Leu Lys Lys Leu Asn Ala Phe Gly Lys Leu Ser Tyr Phe Glu 
                405                 410                 415     


Gly Lys Glu Glu Gln Val Leu Leu Glu Leu Asn Arg Lys Val Lys Asp 
            420                 425                 430         


Gln Asp Leu Leu Phe Asp Gln Phe Asn Pro His Tyr Asn Ile Asn Asn 
        435                 440                 445             


Asn Lys Ile Gly Phe Tyr Thr Phe Ser Ser Gly Lys Glu Lys Ile Gln 
    450                 455                 460                 


Trp Pro Thr Ile Ala Asp Phe Pro Lys Glu Gly Asn Leu His Gln Lys 
465                 470                 475                 480 


Arg Asp Asn Ser Ile Pro Lys Ser Phe Leu Ser Ile His Glu Leu Pro 
                485                 490                 495     


Lys Leu Leu Leu Leu Ala Leu Lys Asp Pro Glu Leu Ala Glu Lys Thr 
            500                 505                 510         


Ile Thr Asp Phe Leu Asp Val Asn Lys Asn Leu Val Leu Asn Lys Ala 
        515                 520                 525             


Ala Leu Gly Gln Ile Arg Asp Lys Ile Lys Leu Cys Pro Ser Ile Phe 
    530                 535                 540                 


Asn Arg Arg Arg Val Glu Glu Lys Ala Leu Lys Gln Lys Gly Arg Ile 
545                 550                 555                 560 


Gln Phe Leu Asn His Ala Gln Ile Lys Asn Leu Arg Gln Arg Asn Lys 
                565                 570                 575     


Ile Thr Asp Glu Arg Leu Ala Asp Leu Lys Phe Met Asp Ser Met Ile 
            580                 585                 590         


Ser Asn Thr Lys Asn Ile Lys Ile Lys Glu Tyr Leu Lys Gln Ile Asn 
        595                 600                 605             


Tyr Asn Gln Val Leu Glu Thr Arg Lys Asp Ala Leu Arg Gln Val Leu 
    610                 615                 620                 


Pro Ala Gly Leu Lys Val Asn Gln Leu Pro Thr Ile Val Ile Asp Tyr 
625                 630                 635                 640 


Leu Leu Gly Met Val Gly Gln Asp Pro His Lys Lys Ile Leu Ala Arg 
                645                 650                 655     


Phe Lys Glu Ile Lys Thr Asp Thr Asn Lys Arg Leu Lys Gln Leu Asp 
            660                 665                 670         


Arg Asp Asp Asp Ser Arg Leu Lys Val Gly Glu Ile Ala Thr Phe Leu 
        675                 680                 685             


Thr Lys Asp Ile Ile Asn Leu Val Ile Ser Glu Asp Leu Lys Lys Lys 
    690                 695                 700                 


Ile Thr Ser Ala Tyr Tyr Gly Arg Ile Gln Tyr Gln Phe Ala Asn Phe 
705                 710                 715                 720 


Ser Ile Ser Lys Gly Glu Leu Thr Thr Ile Ile Glu Gln Leu Gly Leu 
                725                 730                 735     


Phe Asp Asn Ile Lys Gly His Pro Phe Leu Ala Ser Ser Met Leu Asn 
            740                 745                 750         


Lys Val Lys Gly Ile Arg Glu Phe Tyr Asp Asn Tyr Leu Ser Ala Lys 
        755                 760                 765             


Leu Lys Trp Ile Asn Gly Ile Ile Ala Asn Lys Asn Leu Lys Asp Leu 
    770                 775                 780                 


Leu Lys Asn Asn Lys Ile Ser Leu Pro Phe Lys Ile Lys Ser Ile Ile 
785                 790                 795                 800 


Ser Lys Ser Glu Ala Lys Asn Leu Asp Asn Trp Leu Lys Ser Lys Lys 
                805                 810                 815     


Asp Met Pro Val Asp Leu Pro Val Ser Ile Phe Asp Asp Gln Leu Asn 
            820                 825                 830         


Thr Tyr Leu Lys Lys Glu Leu Gln His Val Asn Ile Ala Phe Gln Glu 
        835                 840                 845             


Thr Asp Lys Phe Ser Val Leu Leu Thr Lys Leu Leu Asn Gly Asp Lys 
    850                 855                 860                 


Gln Pro Phe Tyr Asn His Thr Arg Trp Tyr Arg Ser Glu Glu Gly Asp 
865                 870                 875                 880 


Val Pro Phe Ser Pro Asp Gly His Ser Ser Leu Thr Ile Lys Asn Asn 
                885                 890                 895     


Tyr Ser Ser Tyr Ala Glu Leu Thr Glu Lys Lys Ile Arg His Val Gln 
            900                 905                 910         


Thr Gln Asp Arg Val Leu Arg Leu Ala Cys Gln Ser Ile Leu Gly Gln 
        915                 920                 925             


Leu Ser Asp Val Asp Asp Thr Leu Thr Phe Tyr Leu Gln Asp Ile Leu 
    930                 935                 940                 


Ala Phe Thr Asn Thr Asn Pro Leu Asn Arg Pro Ala Thr Phe Lys His 
945                 950                 955                 960 


Lys Leu Lys Glu Ile Ser 
                965     


<210>  2656
<211>  1126
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2656

Met Glu Thr Leu Thr Ile Pro Glu Val Ile Lys Cys Arg Thr Leu Ser 
1               5                   10                  15      


Asp Asp Pro Gln Phe Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Val Phe Asn Ile Ser Asn His Ile Ala Lys Glu Phe Asp Leu Pro Leu 
        35                  40                  45              


Leu Ala Glu Glu Asp His Leu Arg Asn Ser Phe Leu Cys Asn Lys Glu 
    50                  55                  60                  


Asn Lys Lys Ile Asn Trp Asn His Leu Tyr Ser Arg Thr Asn Arg Phe 
65                  70                  75                  80  


Leu Ser Val Leu Lys Val Phe Asp Ala Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Lys Thr Thr Asn Leu Glu Gly Lys Asp Phe Ala Leu Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Ile Val Phe Gly Glu Leu Gln Asp Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Thr Ile Arg Lys Thr Thr Val 
    130                 135                 140                 


Ser Asp Glu Met Ala Leu Phe Leu Lys Val Asn Phe Asn Arg Ala Ile 
145                 150                 155                 160 


Glu Tyr Thr Lys Glu Arg Phe Lys Gly Val Leu Asn Glu Glu Asp Phe 
                165                 170                 175     


Gln Leu Val Ala Ser Lys Lys Val Met Glu Ala Asn Leu Thr Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Cys Leu Ile Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Thr Gly Leu Lys Gly Thr Glu Asn 
    210                 215                 220                 


Lys Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro His Asp Arg Phe Gln Ser Asp Asn Thr Arg Gln Ala Phe Ser 
                245                 250                 255     


Leu Asp Leu Ile Asn Glu Leu Asn Arg Cys Pro Lys Val Leu Tyr Asn 
            260                 265                 270         


Ser Ile Thr Ala Ser Gly Lys Gln Ile Phe Gln Pro Lys Leu Asp Ile 
        275                 280                 285             


Leu Gly Ile Lys Asn Leu Leu Asp Asn Ser Thr Asn Ile Asp Glu Glu 
    290                 295                 300                 


Val Glu Asp Tyr Asp Glu Tyr Ile Glu Ala Leu Thr Lys Arg Ile Arg 
305                 310                 315                 320 


His Ser Asn Arg Phe Ser Asp Phe Ala Leu Lys Tyr Ile Asp Glu Thr 
                325                 330                 335     


Gly Ile Phe Asp Lys Phe Arg Phe Gln Ile Asp Leu Gly Lys Leu Leu 
            340                 345                 350         


Val Asp Glu Tyr Ala Lys Phe Phe Asn Ser Glu Glu Val Pro Arg Arg 
        355                 360                 365             


Ile Ile Glu Asn Val Lys Ala Phe Gly Lys Leu Asn Ser Phe Asn Asp 
    370                 375                 380                 


Glu Ala Lys Val Leu Thr Arg Ile Gly Asn Gly Tyr Pro Ser Lys Glu 
385                 390                 395                 400 


Phe Glu Gln Phe Ser Pro His Tyr Asn Thr Glu Asn Asn Lys Ile Gly 
                405                 410                 415     


Ile Ser Val Lys Glu Asp Thr Ala Lys Leu Arg Pro Asn Ser Lys Gly 
            420                 425                 430         


Glu Thr Gly Lys Lys Leu His Gln Pro Leu Pro Glu Ala Phe Leu Ser 
        435                 440                 445             


Leu His Glu Leu Pro Lys Val Ile Ile Leu Asp Tyr Leu Gln Lys Gly 
    450                 455                 460                 


Glu Pro Glu Arg Leu Ile Glu Asp Phe Ile Leu Ile Asn Asn Ser Lys 
465                 470                 475                 480 


Leu Met Thr Met Pro Phe Ile Glu Ala Val Lys Ser Gln Met Pro Lys 
                485                 490                 495     


Glu Trp Asp Asp Phe Arg Arg Arg Thr Asp Thr Lys Lys Glu Met Ala 
            500                 505                 510         


Tyr Asn Glu Lys Thr Leu Thr Tyr Leu Leu Glu Arg Lys Asn Thr Leu 
        515                 520                 525             


Asn Gln Val Leu Ala Glu Tyr Gln Leu Asn Asp Lys Gln Ile Pro Gly 
    530                 535                 540                 


Arg Ile Leu Asp Tyr Trp Leu Asn Ile Lys Asp Val Glu Glu Gly Arg 
545                 550                 555                 560 


Ala Val Ser Asp Arg Ile Lys Ser Ile Lys Arg Asp Cys Met Ser Arg 
                565                 570                 575     


Leu Arg Ala Leu Glu Lys Phe Lys Ile Asp Arg Asn Arg Asn Lys Ile 
            580                 585                 590         


Pro Lys Ile Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile Val Asp 
        595                 600                 605             


Met Val Ala Gly Glu Glu Lys Lys Gln Lys Ile Thr Ser Phe Tyr Tyr 
    610                 615                 620                 


Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Ser Asp Lys Lys 
625                 630                 635                 640 


Gln Leu Phe Ile His Thr Val Cys Asn Glu Leu Arg Leu Asn Glu Thr 
                645                 650                 655     


Gly Gly His Pro Phe Leu Tyr Lys Leu Asp Leu Gln His Ile Asn Ser 
            660                 665                 670         


Thr Ser Glu Phe Tyr Gly Lys Tyr Leu Gln Glu Lys Gly His Lys Met 
        675                 680                 685             


Val Arg Glu Lys Asn Leu Arg Thr Gly Arg Val Ala Glu Val Asp Gln 
    690                 695                 700                 


Ser Trp Met Ala Thr Thr Phe Tyr Lys Lys Glu Trp Asn Glu Lys Ile 
705                 710                 715                 720 


Gly Lys Gln Leu Thr Val Val Lys Leu Pro Leu Asn Lys Ser Lys Ile 
                725                 730                 735     


Pro Phe Thr Leu Arg Leu Leu Glu Glu Lys Thr Ile Tyr Thr Leu Asp 
            740                 745                 750         


Gln Trp Leu Gln Asn Leu Thr Lys Gly Arg Asn Pro Asn Asp Ala Lys 
        755                 760                 765             


His Pro Val Asn Leu Pro Thr Asn Leu Phe Asp Glu Arg Leu Thr Val 
    770                 775                 780                 


Leu Leu Arg His Asp Leu Asp Glu Arg Gln Ile Ser Tyr Pro Ser Asn 
785                 790                 795                 800 


Ser Tyr Asp Asn Glu Leu Phe Lys Ile Trp Trp Lys Ser Arg Ser Asp 
                805                 810                 815     


Ser Thr Gln Ser Phe Tyr Asn Ala Glu Arg Glu Tyr Val Ile Phe Gly 
            820                 825                 830         


Glu Lys Val Asn Phe Met Pro Asn Thr Lys Asp Asn Phe Ala Asp Tyr 
        835                 840                 845             


Tyr Gln His Ala Phe Thr Thr Ala Tyr Gln Lys Lys Arg Lys Glu Arg 
    850                 855                 860                 


Thr Leu Gln Gln Lys Glu Asp Arg Arg Leu Pro Asn Ile Gln Leu Glu 
865                 870                 875                 880 


Gln Val Glu Lys Thr Phe Lys Gln Thr Ile Ala Gly Thr Glu Lys Glu 
                885                 890                 895     


Ile Arg Met Leu Gln Glu Glu Asp Arg Ile Met Leu Leu Met Ile Glu 
            900                 905                 910         


Ser Leu Leu Glu Asp Gly Lys Lys Met Gln Leu Lys Leu Ser Glu Ile 
        915                 920                 925             


Asp Thr Leu Leu Asn Ala Ala Thr Glu Val Lys Gln Thr Val Ser Ala 
    930                 935                 940                 


Lys Leu Ser Phe Asn Asp Ser Gly Glu Leu Ile Lys Asp Lys Thr Asn 
945                 950                 955                 960 


Pro Ala Ile Val Arg Thr Ile Thr Val Ser Arg Lys Arg Lys Asp Tyr 
                965                 970                 975     


Ser Met Leu Arg Lys Phe Ile Phe Asp Arg Arg Leu Pro Glu Leu Phe 
            980                 985                 990         


Glu Tyr Phe Pro Glu Lys Glu Ile  Gln Leu Asp Ser Leu  Lys Glu Glu 
        995                 1000                 1005             


Leu Asp  Ala Tyr Asn Lys Ala  Lys His Glu Val Phe  Asp Val Val 
    1010                 1015                 1020             


Phe Glu  Leu Glu Ala Lys Ile  Ile Ala Lys Asp Ser  Asp Gly Ile 
    1025                 1030                 1035             


Gln Gln  Leu Phe Ala Asp Glu  Ser Gly Lys Pro Leu  Thr Gly Asn 
    1040                 1045                 1050             


Ile Gln  His Lys Pro Tyr Leu  Thr Trp Leu Lys Asn  Lys Gly Leu 
    1055                 1060                 1065             


Leu Asp  Asp Asn Thr Phe Thr  Phe Leu Asn Met Val  Arg Asn Cys 
    1070                 1075                 1080             


Phe Ser  His Asn Gln Tyr Pro  Gln Lys Lys Thr Met  Glu Arg Leu 
    1085                 1090                 1095             


Ile His  His Trp Glu Pro Asn  Arg Phe Ala Leu Thr  Ile Ala Ser 
    1100                 1105                 1110             


Lys Tyr  Lys Gln Glu Ile Ala  Arg Ile Met Glu Asp  Leu 
    1115                 1120                 1125     


<210>  2657
<211>  1216
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2657

Met Gly Val Ala Asn Met Arg Ala Leu Arg Ile Val Tyr Tyr Ser Leu 
1               5                   10                  15      


Lys Gln Leu Val Met Lys Arg Phe Ser Ser Leu Leu Arg Arg Glu Glu 
            20                  25                  30          


Ile Ser Ser Phe Asp Leu Tyr Thr Asp Phe Gly Thr Lys Ser Pro Leu 
        35                  40                  45              


Leu Ala Ile Tyr Tyr Asn Val Ala Cys Val Asn Trp Glu Gln Thr Gln 
    50                  55                  60                  


Lys Leu Ile Arg Gly Phe Pro Pro Asp Arg Gln Thr Ala Tyr Leu Ala 
65                  70                  75                  80  


Gln Tyr Leu Trp Arg Ala Asn Leu Val Lys Arg Asn Ala Glu Gly Tyr 
                85                  90                  95      


Lys Phe Thr Glu Asp Asp Arg Arg Ile Ala Ala Leu Leu Pro Glu Lys 
            100                 105                 110         


Leu Asp Ala Ile Arg Asn Phe His Ser His Ile Trp His Asp Asn Ser 
        115                 120                 125             


Val Leu Gln Ala Asp Gly Asp Leu Lys Ala Phe Val Glu Lys Lys His 
    130                 135                 140                 


Glu Glu Ala Lys Ala Arg Leu Phe Glu Gln Asn Pro Gln Ser Leu Leu 
145                 150                 155                 160 


Asp Tyr Glu Ala Tyr Ala Lys Gly Lys Ser Lys Tyr Ala Leu Phe Lys 
                165                 170                 175     


Tyr Val Lys Asp Lys Arg Ala Asp Tyr Phe Thr Ile Glu Gly Arg Ile 
            180                 185                 190         


Phe Tyr Leu Ser Phe Phe Leu Thr Ala Gly Gln Met Asn Gln Leu Leu 
        195                 200                 205             


Gln Gln Cys Ser Gly Phe Lys Arg Ala Asp Met Pro Leu Phe Lys Ile 
    210                 215                 220                 


Lys Arg Gln Leu Tyr Thr Tyr Tyr Cys His Arg Asp Gly Ala Thr Leu 
225                 230                 235                 240 


Leu Asp Phe Asn His Asp Gln Glu Val Leu Ala Ser Met Pro Pro Val 
                245                 250                 255     


Glu Lys Gln Ala Ile Ile Arg Ala Arg Thr Ala Phe Lys Leu Val Asn 
            260                 265                 270         


Tyr Leu Tyr Asp Tyr Pro Glu Tyr Trp Gly Ser Ala Asp Trp Met Pro 
        275                 280                 285             


Leu Tyr Asp Glu Ala Gly Glu Arg Ile Asn Ser Gly Glu Ala Leu Lys 
    290                 295                 300                 


Gln Trp Leu Asp Lys Asn Pro Asp Thr Leu Pro Gly Ile Ser Phe Ser 
305                 310                 315                 320 


Phe Ile Pro Ile Lys Lys Ser Pro Ala Asp Ala Asp Lys Lys Glu His 
                325                 330                 335     


Glu Ser Arg Val Arg Ser Gly Thr Leu Ala Phe Thr Val Glu Gly Ile 
            340                 345                 350         


Glu Lys Tyr Glu Phe His Ile Thr Phe Pro Ala Leu His Arg Leu Val 
        355                 360                 365             


Val Leu Gln Arg Leu Tyr Gln Leu Lys Lys Glu Gly Val Ser Pro Leu 
    370                 375                 380                 


Glu Leu Leu Lys Lys Asn Leu Gln Gln Gln Val Asp Asn Arg Ala Ser 
385                 390                 395                 400 


Leu Tyr Ala Ile Leu Ser Lys Arg Glu Arg Leu Arg Thr Glu Asp Glu 
                405                 410                 415     


Trp Glu Tyr Leu Thr Asp Arg Ser His Gln Gln Leu Arg Gly Gly Arg 
            420                 425                 430         


Lys Leu Thr Glu Leu Ser Ile Thr Phe Phe Glu Asn Leu Thr Lys Gly 
        435                 440                 445             


Gly Ala Glu Asn Pro Val Val Thr Thr Arg Leu Leu Asn Leu Ile Arg 
    450                 455                 460                 


Pro Ala Glu Ser Thr Pro Leu Pro Thr Pro Leu Asn Lys Leu Gly Lys 
465                 470                 475                 480 


Thr Arg Phe Thr Asp Asp Thr Glu Pro Asp Ala Ile Gln Val Tyr Glu 
                485                 490                 495     


Gln Asp Tyr Ile Met Gly Ala Thr Gln Lys Phe Arg Ala Gly Asn Arg 
            500                 505                 510         


Phe Met Tyr Tyr Ser Ala Lys Tyr Leu Met Asp Phe Gly Gly Gln Asp 
        515                 520                 525             


Trp Arg Trp Gly Met Glu Lys Phe Ala Met Asp Lys Lys Lys Asn Ser 
    530                 535                 540                 


Asp Thr Lys Glu Ser Leu Leu Lys Ile Lys Glu Tyr Leu Thr Pro Arg 
545                 550                 555                 560 


Glu Ile Leu Glu Ser Asn Asp His Arg Leu Thr Leu Glu Glu Asp His 
                565                 570                 575     


Val Tyr Leu Ala Ile Pro Arg Pro Ala Pro Lys Gly Ser Ala Asn His 
            580                 585                 590         


Gln Gln Tyr Tyr Gln Phe Ala Ile Gly Pro Arg Ala Met Arg Tyr Leu 
        595                 600                 605             


Met Ala Trp Val Phe Glu Lys Arg Asp Lys Ser Pro Glu Glu Ile Ser 
    610                 615                 620                 


Ser Phe Leu Met Glu Leu Ser Gln Asp Leu Glu Leu Leu Tyr Gln Glu 
625                 630                 635                 640 


Gly Ala Trp Asn Ser Glu Leu Pro Val Lys Trp Leu Glu Pro Ala Phe 
                645                 650                 655     


Val Met Gly Tyr Leu Lys Glu Tyr Glu Thr Gly Gly Leu Asp Thr Val 
            660                 665                 670         


Arg Gln Arg Ile Gln Ser Arg Ile Ser His Ile Thr Lys Val Trp Asp 
        675                 680                 685             


His Ala Val Glu His Thr Gln Leu Leu Ser Arg Ser Glu Lys Asn Arg 
    690                 695                 700                 


Leu Ile Met Glu Ala Tyr Arg Phe Tyr Glu Trp Pro Ala Gly Gly Asn 
705                 710                 715                 720 


Gly Val Pro Arg Phe Leu Arg Ala Asp Glu Tyr Asn Gln Met Ser Val 
                725                 730                 735     


Cys His Tyr Ser Leu Gly Leu Lys Lys Lys Gln Gln Thr Val Phe Val 
            740                 745                 750         


His Lys Gly Arg Asn Tyr Asn Asn Lys Tyr Asp Tyr Val Tyr Lys Gly 
        755                 760                 765             


Leu Phe Glu Leu Asp Lys Arg Lys Pro Pro Ile Pro Lys Asp Val Glu 
    770                 775                 780                 


Arg Gln Leu Gln Thr Ala Glu Asn Leu Asp Glu Leu Leu Val Asn Val 
785                 790                 795                 800 


Ile Thr Ser Ile Arg Asp Leu Leu Asn Asp Lys Ile Lys Ser Ile Leu 
                805                 810                 815     


Gly Ala Pro Pro Ala Ile Gln Lys Lys Glu Leu Pro Gly Leu Cys Arg 
            820                 825                 830         


Arg Leu Gly Ile Ser Ile Pro Ala Ser Leu Leu Lys Gly Pro Glu Thr 
        835                 840                 845             


Glu Ser Met Arg Gln Lys His Leu Thr Thr Leu Gln Val Gln Pro Leu 
    850                 855                 860                 


Ala Ile His Pro Met Leu Met Val Lys Lys Leu Phe Pro Gly Phe Tyr 
865                 870                 875                 880 


Ser Pro Ala Gln Thr Asp Ser Gln Ser Gly Ser Thr Asp Lys Thr Leu 
                885                 890                 895     


Lys Arg Pro Asn Leu Pro Val Phe Asp Lys Leu Arg Lys Asn Ala Ser 
            900                 905                 910         


Tyr Arg Lys Arg Leu His Pro Asp Phe Tyr Asn Lys Glu Phe Ala Ser 
        915                 920                 925             


His Leu Phe Pro Glu Asp Gly Asn Lys Lys Gln Arg Glu Lys Leu Ile 
    930                 935                 940                 


Gly Glu Met Asp Arg Thr Cys Ala Glu Asp Ile Leu Leu Trp Gln Met 
945                 950                 955                 960 


Ala His His Tyr Leu Arg Asp Asn His Tyr Thr Glu Thr Leu Ala Gln 
                965                 970                 975     


His Leu Gln Gln Leu Glu Pro Gly His Gln Pro Leu Tyr Asp Trp Leu 
            980                 985                 990         


Lys Leu Pro Ile Val Ile Gln Leu  Lys Pro Arg Asn Glu  Gly Lys Asp 
        995                 1000                 1005             


Leu Tyr  Ile Ser Ile Leu Leu  His Gln Leu Asp Asp  Leu Leu Phe 
    1010                 1015                 1020             


Arg Gln  Glu Arg Asp Arg Leu  Arg Lys Leu Ala Asp  His Phe Thr 
    1025                 1030                 1035             


Tyr Arg  Ile Thr Gln Glu Thr  Ala Leu Trp Glu Asp  Asp Leu Lys 
    1040                 1045                 1050             


Asp Met  Gln Leu Asn Gln Leu  Ser Val Gly Pro Leu  Pro Asp Gly 
    1055                 1060                 1065             


Ser Arg  Gln Asn Pro Ile Pro  Phe Gly Ile Leu Met  Ala Glu Ala 
    1070                 1075                 1080             


Glu Leu  Ile Arg Arg Cys Gly  Gln Gln Leu Ala Glu  Arg Leu Leu 
    1085                 1090                 1095             


Asp Trp  Glu Thr Gly Ile Phe  Glu Gln Leu Leu Ser  Val His Ala 
    1100                 1105                 1110             


Asp Asp  Lys Gln Ser Leu His  Asp Trp Leu Ser Gln  His Val Asp 
    1115                 1120                 1125             


Gly Val  Asp Tyr Tyr Arg Gln  Phe Lys Tyr Ala Phe  Met Asn Phe 
    1130                 1135                 1140             


Asp Asp  Val Leu Ala Val Ala  Val Ser Leu Gly Ile  Glu Ile Ser 
    1145                 1150                 1155             


Glu Ile  Asp Ser Lys Leu Met  Ser Ser Leu Arg Asn  Cys Thr Phe 
    1160                 1165                 1170             


His Asn  Asp Ile Pro Glu Ser  Gly Ser Tyr Ser Trp  Ile Thr Arg 
    1175                 1180                 1185             


Ser Gly  Glu Arg Val Arg Asn  Ile Leu Asn Met Glu  Thr Asp Leu 
    1190                 1195                 1200             


His Ala  Arg Lys Asp Arg Ser  Ala Tyr Glu Lys Lys  Asp 
    1205                 1210                 1215     


<210>  2658
<211>  1146
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2658

Met Glu Ser Ile Ile Gly Leu Gly Leu Ser Phe Asn Pro Tyr Lys Thr 
1               5                   10                  15      


Ala Asp Lys His Tyr Phe Gly Ser Phe Leu Asn Leu Ala Asp Asn Asn 
            20                  25                  30          


Leu Lys Ala Val Phe Ala Glu Phe Lys Glu Arg Ile Ser Asp Lys Ser 
        35                  40                  45              


Lys Asp Glu Asp Ile Ser Asn Leu Ile Glu Lys His Phe Ile Asp Asn 
    50                  55                  60                  


Met Ser Ile Val Asp Tyr Glu Lys Asn Ile Ser Ile Leu Asn Gly Tyr 
65                  70                  75                  80  


Leu Pro Ile Ile Asp Phe Leu Asp Asp Glu Leu Glu Asn Asn Leu Asn 
                85                  90                  95      


Thr Arg Val Lys Asn Phe Lys Lys Ser Phe Ile Ile Leu Ala Glu Ala 
            100                 105                 110         


Leu Glu Thr Leu Arg Asn Tyr Tyr Thr His Phe Tyr His Asp Pro Ile 
        115                 120                 125             


Thr Phe Gly Asp Asn Lys Glu Pro Leu Leu Glu Leu Leu Asp Glu Val 
    130                 135                 140                 


Leu Leu Lys Thr Ile Leu Asp Val Lys Lys Lys Tyr Leu Lys Thr Asp 
145                 150                 155                 160 


Lys Thr Lys Glu Ile Leu Lys Asp Ser Leu Arg Glu Glu Met Asp Leu 
                165                 170                 175     


Leu Val Ile Arg Lys Thr Asp Glu Leu Arg Glu Lys Lys Lys Thr Asn 
            180                 185                 190         


Pro Lys Phe Lys Phe Ser Thr Asp Pro Thr Gln Ile Arg Asn Ser Ile 
        195                 200                 205             


Phe Asn Asp Ala Phe Gln Gly Leu Leu Tyr Glu Asp Lys Glu Asn Asn 
    210                 215                 220                 


Gly Lys Thr Gln Val Ser Tyr Arg Ala Lys Thr Lys Leu Asn Pro Lys 
225                 230                 235                 240 


Asp Ile His Lys Gln Glu Glu Arg Asp Phe Glu Ile Pro Leu Ser Thr 
                245                 250                 255     


Ser Gly Ile Val Phe Leu Met Ser Leu Phe Leu Ser Lys Lys Glu Ile 
            260                 265                 270         


Glu Asp Phe Lys Ser Asn Ile Lys Gly Phe Lys Gly Lys Val Val Lys 
        275                 280                 285             


Asp Glu Asn His Asn Ser Leu Lys Tyr Met Ala Thr His Arg Val Tyr 
    290                 295                 300                 


Ser Ile Leu Ala Phe Lys Gly Leu Lys Tyr Arg Ile Lys Thr Asp Thr 
305                 310                 315                 320 


Phe Ser Lys Val Thr Leu Met Met Gln Met Ile Asp Glu Leu Ser Lys 
                325                 330                 335     


Val Pro Asp Cys Val Tyr Gln Asn Leu Ser Glu Thr Lys Gln Lys Asp 
            340                 345                 350         


Phe Ile Glu Asp Trp Asn Glu Tyr Leu Lys Asp Asn Glu Glu Asn Thr 
        355                 360                 365             


Glu Asn Leu Glu Asn Ser Arg Val Val His Pro Leu Ile Arg Lys Arg 
    370                 375                 380                 


Tyr Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe 
385                 390                 395                 400 


Ala Asn Phe Lys Thr Leu Lys Phe Gln Val Phe Met Gly Tyr Tyr Ile 
                405                 410                 415     


His Asp Gln Arg Thr Lys Thr Ile Gly Thr Thr Asn Ile Thr Thr Glu 
            420                 425                 430         


Arg Thr Val Lys Glu Lys Ile Asn Val Phe Gly Lys Leu Ser Lys Met 
        435                 440                 445             


Asp Asn Leu Lys Lys His Phe Phe Ser Gln Leu Ser Asp Glu Glu Asn 
    450                 455                 460                 


Thr Asp Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Phe Leu Thr Gln 
465                 470                 475                 480 


Ala Asp Asn Ser Pro Ala Asn Asn Ile Pro Ile Tyr Leu Glu Leu Lys 
                485                 490                 495     


Asn Gln Gln Ile Ile Lys Glu Lys Asp Asp Ile Lys Ala Glu Val Asn 
            500                 505                 510         


Asn Ser Gln Asn Arg Asn Pro Asn Lys Pro Ser Lys Arg Asp Leu Leu 
        515                 520                 525             


Asn Lys Ile Ser Asn Thr Asn Glu Asp Phe Tyr Gln Gly Asp Pro Thr 
    530                 535                 540                 


Ala Ile Leu Ser Leu Asn Glu Ile Pro Ala Leu Leu His Leu Phe Leu 
545                 550                 555                 560 


Val Gln Pro Asp Asn Lys Thr Gly Gln Gln Ile Glu Asn Ile Ile Arg 
                565                 570                 575     


Ile Lys Ile Glu Lys Gln Phe Asn Ser Ile Lys Asn Pro Ser Lys Asp 
            580                 585                 590         


Asp Lys Gly Val Pro Lys Ser Leu Phe Ala Asp Thr Asn Val Arg Val 
        595                 600                 605             


Asn Ala Ile Lys Leu Lys Lys Asp Leu Gly Glu Glu Leu Asp Met Leu 
    610                 615                 620                 


Asn Lys Lys Gln Ile Val Phe Lys Glu Asn Gln Lys Ala Ser Ser Asn 
625                 630                 635                 640 


Tyr Asp Glu Leu Leu Lys Lys His Gln Phe Thr Pro Lys Asn Lys Arg 
                645                 650                 655     


Pro Ala Leu Arg Lys Tyr Val Phe Tyr Asn Ser Glu Lys Gly Glu Glu 
            660                 665                 670         


Ala Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Lys Gly Phe 
        675                 680                 685             


Lys Thr Lys Trp Lys Gly Tyr Gln His Ser Glu Leu Gln Arg Lys Leu 
    690                 695                 700                 


Ala Phe Tyr Asp Arg His Thr Lys Gln Asp Ile Lys Glu Leu Leu Ser 
705                 710                 715                 720 


Gly Cys Glu Phe Asp His Phe Leu Leu Asp Ile Asn Ala Cys Phe Lys 
                725                 730                 735     


Glu Asp Asp Phe Glu Asp Phe Phe Ser Lys Tyr Leu Lys Asn Arg Ile 
            740                 745                 750         


Glu Thr Leu Asn Ile Ile Leu Lys Gln Leu His Asp Phe Lys Asn Glu 
        755                 760                 765             


Pro Thr Pro Leu Lys Gly Val Phe Lys Asn Cys Leu Lys Phe Leu Lys 
    770                 775                 780                 


Gln Lys Asn Tyr Val Thr Glu Asn Pro Glu Ile Ile Lys Lys Arg Ile 
785                 790                 795                 800 


Leu Ala Lys Pro Ala Phe Leu Pro Arg Gly Ile Phe Asp Glu Arg Pro 
                805                 810                 815     


Thr Met Lys Lys Gly Lys Asn Pro Leu Ile Asp Arg Asp Glu Phe Ala 
            820                 825                 830         


Lys Trp Phe Val Glu Tyr Leu Glu Asn Lys Asp Tyr Gln Lys Phe Tyr 
        835                 840                 845             


Asn Ser Glu Glu Tyr Arg Ile Arg Asp Ala Asp Phe Lys Lys Asn Ala 
    850                 855                 860                 


Val Ile Lys Lys Gln Lys Leu Lys Asp Phe Tyr Thr Leu Gln Met Val 
865                 870                 875                 880 


Asn Tyr Leu Leu Lys Glu Val Phe Gly Lys Asp Glu Met Asn Leu Gln 
                885                 890                 895     


Leu Ser Glu Leu Phe Gln Thr Arg Gln Glu Arg Leu Lys Leu Gln Gly 
            900                 905                 910         


Ile Ala Lys Lys Gln Met Asn Lys Glu Thr Gly Asp Ser Ser Glu Asn 
        915                 920                 925             


Thr Arg Asn Gln Thr Tyr Ile Trp Asn Lys Asp Val Pro Val Ser Phe 
    930                 935                 940                 


Phe Asn Gly Lys Val Thr Ile Asp Lys Val Lys Leu Lys Asn Ile Gly 
945                 950                 955                 960 


Lys Tyr Lys Arg Tyr Glu Arg Asp Glu Arg Val Lys Thr Phe Ile Gly 
                965                 970                 975     


Tyr Glu Val Asp Glu Lys Trp Met Met Tyr Leu Pro His Asn Trp Lys 
            980                 985                 990         


Asp Arg Tyr Ser Val Lys Pro Ile  Asn Val Ile Asp Leu  Gln Ile Gln 
        995                 1000                 1005             


Glu Tyr  Glu Glu Ile Arg Ser  His Glu Leu Leu Lys  Glu Ile Gln 
    1010                 1015                 1020             


Asn Leu  Glu Gln Tyr Ile Tyr  Asp His Thr Thr Asp  Lys Asn Thr 
    1025                 1030                 1035             


Leu Leu  Gln Asp Gly Asn Pro  Asn Phe Lys Met Tyr  Val Leu Asn 
    1040                 1045                 1050             


Gly Leu  Leu Thr Gly Ile Lys  Gln Val Asn Ile Ala  Asp Phe Ile 
    1055                 1060                 1065             


Val Leu  Lys Gln Asn Thr Asn  Phe Asp Lys Ile Asp  Phe Thr Gly 
    1070                 1075                 1080             


Ile Ala  Ser Cys Ser Glu Leu  Glu Lys Lys Thr Ile  Ile Leu Ile 
    1085                 1090                 1095             


Ala Ile  Arg Asn Lys Phe Ala  His Asn Gln Leu Pro  Asn Lys Thr 
    1100                 1105                 1110             


Ile Tyr  Asp Leu Ala Asn Glu  Phe Leu Lys Lys Glu  Lys Arg Glu 
    1115                 1120                 1125             


Thr Tyr  Ala Asn Tyr Tyr Leu  Lys Val Leu Lys Lys  Met Ile Ser 
    1130                 1135                 1140             


Asp Leu  Ala 
    1145     


<210>  2659
<211>  1126
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2659

Met Glu Thr Leu Thr Ile Pro Glu Val Ile Lys Cys Arg Thr Leu Ser 
1               5                   10                  15      


Asp Asp Pro Gln Phe Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Val Phe Asn Ile Ser Asn His Ile Ala Lys Glu Phe Asp Leu Pro Leu 
        35                  40                  45              


Leu Ala Glu Glu Asp His Leu Arg Asn Ser Phe Leu Cys Asn Lys Glu 
    50                  55                  60                  


Asn Lys Lys Ile Asn Trp Asn His Leu Tyr Ser Arg Thr Asn Arg Phe 
65                  70                  75                  80  


Leu Ser Val Leu Lys Val Phe Asp Ala Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Lys Thr Thr Asn Leu Glu Gly Lys Asp Phe Ala Leu Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Ile Val Phe Gly Glu Leu Gln Asp Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Thr Ile Arg Lys Thr Thr Val 
    130                 135                 140                 


Ser Asp Glu Met Ala Leu Phe Leu Lys Val Asn Phe Asn Arg Ala Ile 
145                 150                 155                 160 


Glu Tyr Thr Lys Glu Arg Phe Lys Gly Val Leu Asn Glu Glu Asp Phe 
                165                 170                 175     


Gln Leu Val Ala Ser Lys Lys Val Met Glu Ala Asn Leu Thr Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Cys Leu Ile Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Thr Gly Leu Lys Gly Thr Glu Asn 
    210                 215                 220                 


Lys Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro His Asp Arg Phe Gln Ser Asp Asn Thr Arg Gln Ala Phe Ser 
                245                 250                 255     


Leu Asp Leu Ile Asn Glu Leu Asn Arg Cys Pro Lys Val Leu Tyr Asn 
            260                 265                 270         


Ser Ile Thr Ala Ser Gly Lys Gln Ile Phe Gln Pro Lys Leu Asp Ile 
        275                 280                 285             


Leu Gly Ile Lys Asn Leu Leu Asp Asn Ser Thr Asn Ile Asp Glu Glu 
    290                 295                 300                 


Val Glu Asp Tyr Asp Glu Tyr Ile Glu Ala Leu Thr Lys Arg Ile Arg 
305                 310                 315                 320 


His Ser Asn Arg Phe Ser Asp Phe Ala Leu Lys Tyr Ile Asp Glu Thr 
                325                 330                 335     


Gly Ile Phe Asp Lys Phe Arg Phe Gln Ile Asp Leu Gly Lys Leu Leu 
            340                 345                 350         


Val Asp Glu Tyr Ala Lys Phe Phe Asn Ser Glu Glu Val Pro Arg Arg 
        355                 360                 365             


Ile Ile Glu Asn Val Lys Ala Phe Gly Lys Leu Asn Ser Phe Asn Asp 
    370                 375                 380                 


Glu Ala Lys Val Leu Thr Arg Ile Gly Asn Gly Tyr Pro Ser Lys Glu 
385                 390                 395                 400 


Phe Glu Gln Phe Ser Pro His Tyr Asn Thr Glu Asn Asn Lys Ile Gly 
                405                 410                 415     


Ile Ser Val Lys Glu Asp Thr Ala Lys Leu Arg Pro Asn Ser Lys Gly 
            420                 425                 430         


Glu Thr Gly Lys Lys Leu His Gln Pro Leu Pro Glu Ala Phe Leu Ser 
        435                 440                 445             


Leu His Glu Leu Pro Lys Val Ile Ile Leu Asp Tyr Leu Gln Lys Gly 
    450                 455                 460                 


Glu Pro Glu Arg Leu Ile Glu Asp Phe Ile Leu Ile Asn Asn Ser Lys 
465                 470                 475                 480 


Leu Met Thr Met Pro Phe Ile Glu Ala Val Lys Ser Gln Met Pro Lys 
                485                 490                 495     


Glu Trp Asp Asp Phe Arg Arg Arg Thr Asp Thr Lys Lys Glu Met Ala 
            500                 505                 510         


Tyr Asn Glu Lys Thr Leu Thr Tyr Leu Leu Glu Arg Lys Asn Thr Leu 
        515                 520                 525             


Asn Gln Val Leu Ala Glu Tyr Gln Leu Asn Asp Lys Gln Ile Pro Gly 
    530                 535                 540                 


Arg Ile Leu Asp Tyr Trp Leu Asn Ile Lys Asp Val Glu Glu Gly Arg 
545                 550                 555                 560 


Ala Val Ser Asp Arg Ile Lys Ser Ile Lys Arg Asp Cys Met Ser Arg 
                565                 570                 575     


Leu Arg Ala Leu Glu Lys Phe Lys Ile Asp Arg Asn Arg Asn Lys Ile 
            580                 585                 590         


Pro Lys Ile Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile Val Asp 
        595                 600                 605             


Met Val Ala Gly Glu Glu Lys Lys Gln Lys Ile Thr Ser Phe Tyr Tyr 
    610                 615                 620                 


Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Ser Asp Lys Lys 
625                 630                 635                 640 


Gln Leu Phe Ile His Thr Val Cys Asn Glu Leu Arg Leu Asn Glu Thr 
                645                 650                 655     


Gly Gly His Pro Phe Leu Tyr Lys Leu Asp Leu Gln His Ile Asn Ser 
            660                 665                 670         


Thr Ser Glu Phe Tyr Gly Lys Tyr Leu Gln Glu Lys Gly His Lys Met 
        675                 680                 685             


Val Arg Glu Lys Asn Leu Arg Thr Gly Arg Val Ala Glu Val Asp Gln 
    690                 695                 700                 


Ser Trp Met Ala Thr Thr Phe Tyr Lys Lys Glu Trp Asn Glu Lys Ile 
705                 710                 715                 720 


Gly Lys Gln Leu Thr Val Val Lys Leu Pro Leu Asn Lys Ser Lys Ile 
                725                 730                 735     


Pro Phe Thr Leu Arg Leu Leu Glu Glu Lys Thr Ile Tyr Thr Leu Asp 
            740                 745                 750         


Gln Trp Leu Gln Asn Leu Thr Lys Gly Arg Asn Pro Asn Asp Ala Lys 
        755                 760                 765             


His Pro Val Asn Leu Pro Thr Asn Leu Phe Asp Glu Arg Leu Thr Val 
    770                 775                 780                 


Leu Leu Arg His Asp Leu Asp Glu Arg Gln Ile Ser Tyr Pro Ser Asn 
785                 790                 795                 800 


Ser Tyr Asp Asn Glu Leu Phe Lys Ile Trp Trp Lys Ser Arg Ser Asp 
                805                 810                 815     


Ser Thr Gln Ser Phe Tyr Asn Ala Glu Arg Glu Tyr Val Ile Phe Gly 
            820                 825                 830         


Glu Lys Val Asn Phe Met Pro Asn Thr Lys Asp Asn Phe Ala Asp Tyr 
        835                 840                 845             


Tyr Gln His Ala Phe Thr Thr Ala Tyr Gln Lys Lys Arg Lys Glu Arg 
    850                 855                 860                 


Thr Leu Gln Gln Lys Glu Asp Arg Arg Leu Pro Asn Ile Gln Leu Glu 
865                 870                 875                 880 


Gln Val Glu Lys Thr Phe Lys Gln Thr Ile Ala Gly Thr Glu Lys Glu 
                885                 890                 895     


Ile Arg Met Leu Gln Glu Glu Asp Arg Ile Met Leu Leu Met Ile Glu 
            900                 905                 910         


Ser Leu Leu Glu Asp Gly Lys Lys Met Gln Leu Lys Leu Ser Glu Ile 
        915                 920                 925             


Asp Thr Leu Leu Asn Ala Ala Thr Glu Val Lys Gln Thr Val Ser Ala 
    930                 935                 940                 


Lys Leu Ser Phe Asn Asp Ser Gly Glu Leu Ile Lys Asp Lys Thr Asn 
945                 950                 955                 960 


Pro Ala Ile Val Arg Thr Ile Thr Val Ser Arg Lys Arg Lys Asp Tyr 
                965                 970                 975     


Ser Met Leu Arg Lys Phe Ile Phe Asp Arg Arg Leu Pro Glu Leu Phe 
            980                 985                 990         


Glu Tyr Phe Pro Glu Lys Glu Ile  Gln Leu Asp Ser Leu  Lys Glu Glu 
        995                 1000                 1005             


Leu Asp  Ala Tyr Asn Lys Ala  Lys His Glu Val Phe  Asp Val Val 
    1010                 1015                 1020             


Phe Glu  Leu Glu Ala Lys Ile  Ile Ala Lys Asp Ser  Asp Gly Ile 
    1025                 1030                 1035             


Gln Gln  Leu Phe Ala Asp Glu  Ser Gly Lys Pro Leu  Thr Gly Asn 
    1040                 1045                 1050             


Ile Gln  His Lys Pro Tyr Leu  Thr Trp Leu Lys Asn  Lys Gly Leu 
    1055                 1060                 1065             


Leu Asp  Asp Asn Thr Phe Thr  Phe Leu Asn Met Val  Arg Asn Cys 
    1070                 1075                 1080             


Phe Ser  His Asn Gln Tyr Pro  Gln Lys Lys Thr Met  Glu Arg Leu 
    1085                 1090                 1095             


Ile His  His Trp Glu Pro Asn  Arg Phe Ala Leu Thr  Ile Ala Ser 
    1100                 1105                 1110             


Lys Tyr  Lys Gln Glu Ile Ala  Arg Ile Met Glu Asp  Leu 
    1115                 1120                 1125     


<210>  2660
<211>  1116
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2660

Leu Gln Gln Thr Asn Ser Arg Asn Gly Lys Phe Thr Leu Ile Lys His 
1               5                   10                  15      


Ser Ile Asn Gln Tyr Asn Phe Thr Thr Met Arg Ile Pro Ser Leu Ile 
            20                  25                  30          


Glu Asn Asn Lys Lys Tyr Tyr Ala Ile His Ser Glu Met Ala Leu Leu 
        35                  40                  45              


Asn Ala Gln Ala Val Leu Asp His Ile Gln Lys Met Ala Gly Ile Glu 
    50                  55                  60                  


Ala Cys Ala Tyr Asn Glu Lys Glu Lys Lys Pro Ser Asp Glu Asp Leu 
65                  70                  75                  80  


Trp Val His Pro Val Met Ile Phe Leu Asp Lys Ala Lys Thr Ser Glu 
                85                  90                  95      


Val Lys Ala Glu Lys Val Gln Tyr Val Ile Glu Arg Leu Cys Ser Tyr 
            100                 105                 110         


Phe Pro Phe Met Asn Ile Met Ala Gln Phe Gln Arg Glu Tyr Asp Asn 
        115                 120                 125             


Glu His Asn Lys Thr Asn Arg Leu Glu Val Asn Ala Asn Asp Met Tyr 
    130                 135                 140                 


Asp Ala Leu Asn Lys Ile Phe Arg Val Leu Lys Lys Tyr Arg Asp Tyr 
145                 150                 155                 160 


Ser Ala His Tyr Lys Phe Glu Asp Asn Cys Phe Ile Asp Gly Cys Ala 
                165                 170                 175     


Phe Leu Arg Tyr Ser Glu Gln Pro Leu Ala Ser Met Val Arg Lys Tyr 
            180                 185                 190         


Tyr Asp Val Ala Leu Arg Asn Ile Lys Glu Lys Tyr Asn Tyr Lys Thr 
        195                 200                 205             


Glu Glu Leu Ala Phe Ile Gln Asn Lys Arg Tyr Lys Ile Thr Lys Gly 
    210                 215                 220                 


Ile Asp Gly Arg Lys Lys Thr Phe Gly Asn Pro Asn Phe Phe Leu Thr 
225                 230                 235                 240 


Leu Thr Ser Asn Asn Gly Asp Thr Thr Asn Lys Trp His Leu Ser Gly 
                245                 250                 255     


Val Gly Val Ala Leu Leu Ile Ser Leu Phe Leu Asp Lys Gln Tyr Val 
            260                 265                 270         


Asn Leu Phe Trp Thr Arg Leu Pro Ile Phe Ser Asp Asn Lys Leu Lys 
        275                 280                 285             


Glu Asp Glu Arg Arg Val Ile Ile Arg Ser Met Gly Ile Asn Ser Val 
    290                 295                 300                 


Lys Leu Pro Lys Asp Arg Ile His Met Asp Lys Asp Asp Met Ser Val 
305                 310                 315                 320 


Ala Met Asp Met Leu Asn Glu Leu Lys Arg Cys Pro Asp Glu Leu Phe 
                325                 330                 335     


Asp Ile Leu Pro Ala Glu Lys Gln Ala His Phe Arg Ile Ile Ser Ser 
            340                 345                 350         


Asp His Asn Glu Val Leu Met Lys Arg Ser Thr Asp Arg Phe Thr Ser 
        355                 360                 365             


Met Leu Leu Gln Tyr Ile Asp Tyr Gly Lys Lys Phe Lys Gln Ile Arg 
    370                 375                 380                 


Phe His Val Asn Met Gly Lys Leu Arg Tyr Leu Leu Asn Ala Glu Lys 
385                 390                 395                 400 


Asn Cys Ile Asp Gly Asn Ile Arg Thr Arg Val Ile Glu His Pro Leu 
                405                 410                 415     


Asn Gly Tyr Gly Arg Ile Asp Glu Ile Glu Glu Leu Arg Lys Asn Glu 
            420                 425                 430         


Asp Met Thr Tyr Ala Asp Thr Gly Ile Arg Ile Lys Asp Phe Glu Ser 
        435                 440                 445             


Met Thr Arg Asp Asp Ser Asp Thr Ala Asn Tyr Pro Tyr Val Val Asp 
    450                 455                 460                 


Thr Tyr Thr His Tyr Leu Leu Glu Asn Asn Lys Val Glu Phe Ser Phe 
465                 470                 475                 480 


Cys Gly Asn Ala Ser Leu Pro Glu Val Ser Glu Arg Asn Gly Lys Trp 
                485                 490                 495     


Tyr Val Ser Lys Val Val Pro Ala Cys Arg Met Ser Ile Leu Glu Leu 
            500                 505                 510         


Pro Ala Met Ala Phe His Met Leu Leu Leu Gly Ser Glu Lys Thr Glu 
        515                 520                 525             


Ala Arg Ile Lys Ser Val Tyr Asp Asn Tyr Cys Arg Leu Phe Glu Ala 
    530                 535                 540                 


Met Arg Lys Gly Gln Val Ser Met Asp Asn Leu Ser Asp Phe Gly Ile 
545                 550                 555                 560 


Ala Pro Glu Asp Ile Pro Gln Arg Val Met Asn Cys Ile Asn Gly Ser 
                565                 570                 575     


Gly Gln Gly Lys Asp Leu Val Gly Phe Ile Ser Arg Lys Leu Glu Ala 
            580                 585                 590         


Met Ser Glu Asp Thr Arg Tyr Arg Leu Glu Arg Leu Ser Glu Asp Arg 
        595                 600                 605             


Lys Ala Ile Gly Ser Arg Asp Asn Lys Met Gly Lys Arg Gly Tyr Arg 
    610                 615                 620                 


Gln Ile Arg Thr Gly Val Phe Ala Asp Phe Leu Ala Lys Asp Ile Val 
625                 630                 635                 640 


Leu Leu Gln Leu Ala Gly Asn Asn Gly Thr Asn Lys Met Thr Gly Leu 
                645                 650                 655     


Asn Tyr Arg Val Met Gln Ser Ser Ile Ala Thr Tyr Asp Ser His Gly 
            660                 665                 670         


Asp Ile Glu Thr Lys Lys Glu Phe Lys Ala Leu Phe Glu Arg Ala Asn 
        675                 680                 685             


Leu Leu Val Cys Asn Pro Lys Ser Gly His Pro Phe Leu Phe Lys Val 
    690                 695                 700                 


Phe Ala Arg Ser Ile Pro Glu Asn Ala Ile Glu Phe Tyr Glu Arg Tyr 
705                 710                 715                 720 


Leu Tyr Glu Arg Gln Ala Tyr Leu Asp Gly Ile Arg Ile Lys Ile Ala 
                725                 730                 735     


Lys Gly Lys Thr Pro Asp Val Pro Phe Val Asn Lys Asn Gln Met Lys 
            740                 745                 750         


Trp Lys Ser Pro Ala Gln Glu Asp Leu Ser Leu Ser Tyr Thr Asp Asn 
        755                 760                 765             


Leu Ala Ile Glu Leu Pro Arg Gln Met Phe Asp Ala Asp Ile Lys Asp 
    770                 775                 780                 


Cys Leu Met Arg Met Asp Lys Met Lys Asp Val Asp Phe Ser Asn Ala 
785                 790                 795                 800 


Asn Val Thr Tyr Leu Ile Ala Glu Tyr Met His Arg Val Leu Asn Asp 
                805                 810                 815     


Asp Phe Gln Pro Phe Tyr Gly Trp Glu Arg Asn Tyr Pro Phe Ile Asp 
            820                 825                 830         


Met Leu Arg Leu Lys Thr Asp Lys Lys Gly Ser Leu Cys Ala Ser Phe 
        835                 840                 845             


Thr Ser Val Asp Glu Arg Ala Glu Leu Trp Lys Arg Arg Asp Glu Leu 
    850                 855                 860                 


Met Asp Ala Tyr Arg Gln Trp Val Val Arg Asn Ser Gly Arg Lys Gly 
865                 870                 875                 880 


Met Ser Arg Asp Glu Ala Glu Glu Cys Ala Asp Arg Arg Leu Val Ser 
                885                 890                 895     


Ser Arg Asn Glu Tyr Gln Lys Thr Glu Lys Val Ile Arg Arg Tyr Lys 
            900                 905                 910         


Val Gln Asp Ala Leu Leu Phe Leu Met Ala Lys Asp Val Met Thr Lys 
        915                 920                 925             


Tyr Ala Glu Tyr Asp Gly Asp Met Phe Ser Leu Lys Glu Ile Met Pro 
    930                 935                 940                 


Asn Ser Asp Lys Gly Ile Leu Ser Val Ile Met Pro Met Thr Phe Thr 
945                 950                 955                 960 


Phe Glu Lys Asn Gly Glu Lys Ile Thr Ile Lys Ser Ser Gly Met Lys 
                965                 970                 975     


Leu Lys Asn Phe Gly Asp Phe Phe Pro Leu Ala Asn Asp Arg Arg Leu 
            980                 985                 990         


Ile Asn Leu Ser Arg Leu Ile Gly  Thr Asn Thr Ile Ser  Lys Glu Asp 
        995                 1000                 1005             


Leu Glu  Glu Glu Phe Lys Asn  Tyr Asp Gln Cys Arg  Pro Glu Met 
    1010                 1015                 1020             


Ala Ser  Leu Ile Leu Asp Ile  Glu Lys Tyr Ala Phe  Asp Met Tyr 
    1025                 1030                 1035             


Pro Gln  Leu Glu Lys Lys Leu  Asn Ser Thr Asn Asn  Lys Val Gln 
    1040                 1045                 1050             


Phe Lys  Asp Ile Leu Gln Ala  Leu Lys Gln Asp Ala  Lys Ile Asp 
    1055                 1060                 1065             


Asp Ala  Arg Gly Asn Val Leu  Arg Leu Ile Arg Asn  Ala Phe Glu 
    1070                 1075                 1080             


His Asn  Asn Tyr Pro Asp Lys  Gly Ile Val Glu Ile  Ser Thr Leu 
    1085                 1090                 1095             


Pro Glu  Val Ala Arg Glu Leu  Lys Ala Val Phe Glu  Lys Tyr Thr 
    1100                 1105                 1110             


Ile Cys  Lys 
    1115     


<210>  2661
<211>  1146
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2661

Met Glu Ser Ile Ile Gly Leu Gly Leu Ser Phe Asn Pro Tyr Lys Thr 
1               5                   10                  15      


Ala Asp Lys His Tyr Phe Gly Ser Phe Leu Asn Leu Ala Asp Asn Asn 
            20                  25                  30          


Leu Lys Ala Val Phe Ala Glu Phe Lys Glu Arg Ile Ser Asp Lys Ser 
        35                  40                  45              


Lys Asp Glu Asp Ile Ser Asn Leu Ile Glu Lys His Phe Ile Asp Asn 
    50                  55                  60                  


Met Ser Ile Val Asp Tyr Glu Lys Asn Ile Ser Ile Leu Asn Gly Tyr 
65                  70                  75                  80  


Leu Pro Ile Ile Asp Phe Leu Asp Asp Glu Leu Glu Asn Asn Leu Asn 
                85                  90                  95      


Thr Arg Val Lys Asn Phe Lys Lys Ser Phe Ile Ile Leu Ala Glu Ala 
            100                 105                 110         


Leu Glu Thr Leu Arg Asn Tyr Tyr Thr His Phe Tyr His Asp Pro Ile 
        115                 120                 125             


Thr Phe Gly Asp Asn Lys Glu Pro Leu Leu Glu Leu Leu Asp Glu Val 
    130                 135                 140                 


Leu Leu Lys Thr Ile Leu Asp Val Lys Lys Lys Tyr Leu Lys Thr Asp 
145                 150                 155                 160 


Lys Thr Lys Glu Ile Leu Lys Asp Ser Leu Arg Glu Glu Ile Asp Leu 
                165                 170                 175     


Leu Val Ile Arg Lys Thr Asp Glu Leu Arg Glu Lys Lys Lys Ala Asn 
            180                 185                 190         


Pro Arg Phe Lys Phe Ser Thr Asp Pro Thr Gln Ile Arg Asn Ser Ile 
        195                 200                 205             


Phe Asn Asp Ala Phe Gln Gly Leu Leu Tyr Glu Asp Lys Glu Asn Asn 
    210                 215                 220                 


Gly Lys Thr Gln Val Ser Tyr Arg Ala Lys Thr Lys Leu Asn Pro Lys 
225                 230                 235                 240 


Asp Ile His Lys Gln Glu Glu Arg Asp Phe Glu Ile Pro Leu Ser Thr 
                245                 250                 255     


Ser Gly Ile Val Phe Leu Met Ser Leu Phe Leu Ser Lys Lys Glu Ile 
            260                 265                 270         


Glu Asp Phe Lys Ser Asn Ile Lys Gly Phe Lys Gly Lys Val Val Lys 
        275                 280                 285             


Asp Glu Asn His Asn Ser Leu Lys Tyr Met Ala Thr His Arg Val Tyr 
    290                 295                 300                 


Ser Ile Leu Ala Phe Lys Gly Leu Lys Tyr Arg Ile Lys Thr Asp Thr 
305                 310                 315                 320 


Phe Ser Lys Val Thr Leu Met Met Gln Met Ile Asp Glu Leu Ser Lys 
                325                 330                 335     


Val Pro Asp Cys Val Tyr Gln Asn Leu Ser Glu Thr Lys Gln Lys Asp 
            340                 345                 350         


Phe Ile Glu Asp Trp Asn Glu Tyr Leu Lys Asp Asn Glu Glu Asn Thr 
        355                 360                 365             


Glu Asn Leu Glu Asn Ser Arg Val Val His Pro Leu Ile Arg Lys Arg 
    370                 375                 380                 


Tyr Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe 
385                 390                 395                 400 


Ala Asn Phe Lys Thr Leu Lys Phe Gln Val Phe Met Gly Tyr Tyr Ile 
                405                 410                 415     


His Asp Gln Arg Thr Lys Thr Ile Gly Thr Thr Asn Ile Thr Thr Glu 
            420                 425                 430         


Arg Thr Val Lys Glu Lys Ile Asn Val Phe Gly Lys Leu Ser Lys Met 
        435                 440                 445             


Asp Asn Leu Lys Lys His Phe Phe Ser Gln Leu Ser Asp Glu Glu Asn 
    450                 455                 460                 


Thr Asp Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Phe Leu Thr Gln 
465                 470                 475                 480 


Ala Asp Asn Ser Pro Ala Asn Asn Ile Pro Ile Tyr Leu Glu Leu Lys 
                485                 490                 495     


Asn Gln Gln Ile Ile Lys Glu Lys Asp Asp Ile Lys Ala Glu Val Asn 
            500                 505                 510         


Asn Ser Gln Asn Arg Asn Pro Asn Lys Pro Ser Lys Arg Asp Leu Leu 
        515                 520                 525             


Asn Lys Ile Ser Asn Thr Asn Glu Asp Phe Tyr Gln Glu Asp Pro Thr 
    530                 535                 540                 


Ala Ile Leu Ser Leu Asn Glu Ile Pro Ala Leu Leu His Leu Phe Leu 
545                 550                 555                 560 


Val Gln Pro Asp Asn Lys Thr Gly Gln Gln Ile Glu Asn Ile Ile Arg 
                565                 570                 575     


Ile Lys Ile Glu Lys Gln Phe Asn Ser Ile Lys Asn Pro Ser Lys Asp 
            580                 585                 590         


Asp Lys Gly Val Pro Lys Ser Leu Phe Ala Asp Thr Asn Val Arg Val 
        595                 600                 605             


Asn Ala Ile Lys Leu Lys Lys Asp Leu Gly Glu Glu Leu Asp Met Leu 
    610                 615                 620                 


Asn Lys Lys Gln Ile Val Phe Lys Glu Asn Gln Lys Ala Ser Ser Asn 
625                 630                 635                 640 


Tyr Asp Glu Leu Leu Lys Lys His Gln Phe Thr Pro Lys Asn Lys Arg 
                645                 650                 655     


Pro Ala Leu Arg Lys Tyr Val Phe Tyr Asn Ser Glu Lys Gly Glu Glu 
            660                 665                 670         


Ala Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Lys Gly Phe 
        675                 680                 685             


Lys Thr Lys Trp Lys Glu Tyr Gln His Ser Glu Leu Gln Arg Lys Leu 
    690                 695                 700                 


Ala Phe Tyr Asp Arg His Thr Lys Gln Asp Ile Lys Glu Leu Leu Ser 
705                 710                 715                 720 


Gly Cys Glu Phe Asp His Phe Leu Leu Asp Ile Asn Ala Cys Phe Lys 
                725                 730                 735     


Glu Asp Asp Phe Glu Asp Phe Phe Ser Lys Tyr Leu Lys Asn Arg Ile 
            740                 745                 750         


Glu Thr Leu Asn Ile Ile Leu Lys Gln Leu His Asp Phe Lys Asn Glu 
        755                 760                 765             


Pro Thr Pro Leu Lys Gly Val Phe Lys Asn Cys Leu Lys Phe Leu Lys 
    770                 775                 780                 


Gln Lys Asn Tyr Val Thr Glu Asn Pro Glu Ile Ile Lys Lys Arg Ile 
785                 790                 795                 800 


Leu Ala Lys Pro Ala Phe Leu Pro Arg Gly Ile Phe Asp Glu Arg Pro 
                805                 810                 815     


Thr Met Lys Lys Gly Lys Asn Pro Leu Ile Asp Arg Asp Glu Phe Ala 
            820                 825                 830         


Lys Trp Phe Val Glu Tyr Leu Glu Asn Lys Asp Tyr Gln Lys Phe Tyr 
        835                 840                 845             


Asn Ser Glu Glu Tyr Arg Ile Arg Asp Ala Asp Phe Lys Lys Asn Ala 
    850                 855                 860                 


Val Ile Lys Lys Gln Lys Leu Lys Asp Phe Tyr Thr Leu Gln Met Val 
865                 870                 875                 880 


Asn Tyr Leu Leu Lys Glu Val Phe Gly Lys Asp Glu Met Asn Leu Gln 
                885                 890                 895     


Leu Ser Glu Leu Phe Gln Thr Arg Gln Glu Arg Leu Lys Leu Gln Gly 
            900                 905                 910         


Ile Ala Lys Lys Gln Met Asn Lys Glu Thr Gly Asp Ser Ser Glu Asn 
        915                 920                 925             


Thr Arg Asn Gln Thr Tyr Ile Trp Asn Lys Asp Val Pro Val Ser Phe 
    930                 935                 940                 


Phe Asn Gly Lys Val Thr Ile Asp Lys Val Lys Leu Lys Asn Ile Gly 
945                 950                 955                 960 


Lys Tyr Lys Arg Tyr Glu Arg Asp Glu Arg Val Lys Thr Phe Ile Gly 
                965                 970                 975     


Tyr Glu Val Asp Glu Lys Trp Met Met Tyr Leu Pro His Asn Trp Lys 
            980                 985                 990         


Asp Arg Tyr Ser Val Lys Pro Ile  Asn Val Ile Asp Leu  Gln Ile Gln 
        995                 1000                 1005             


Glu Tyr  Glu Glu Ile Arg Ser  His Glu Leu Leu Lys  Glu Ile Gln 
    1010                 1015                 1020             


Asn Leu  Glu Gln Tyr Ile Tyr  Asp His Thr Thr Asp  Lys Asn Thr 
    1025                 1030                 1035             


Leu Leu  Gln Asp Gly Asn Pro  Asn Phe Lys Met Tyr  Val Leu Asn 
    1040                 1045                 1050             


Gly Leu  Leu Thr Gly Ile Lys  Gln Val Asn Ile Ala  Asp Phe Ile 
    1055                 1060                 1065             


Val Leu  Lys Gln Asn Thr Asn  Phe Asp Lys Ile Asp  Phe Thr Gly 
    1070                 1075                 1080             


Ile Ala  Ser Cys Ser Glu Leu  Glu Lys Lys Thr Ile  Ile Leu Ile 
    1085                 1090                 1095             


Ala Ile  Arg Asn Lys Phe Ala  His Asn Gln Leu Pro  Asn Lys Thr 
    1100                 1105                 1110             


Ile Tyr  Asp Leu Ala Asn Glu  Phe Leu Lys Lys Glu  Lys Arg Glu 
    1115                 1120                 1125             


Thr Tyr  Ala Asn Tyr Tyr Leu  Lys Val Leu Lys Lys  Met Ile Ser 
    1130                 1135                 1140             


Asp Leu  Ala 
    1145     


<210>  2662
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2662

Leu Gln Lys Gln Asp Lys Leu Phe Val Asp Arg Lys Lys Asn Ala Ile 
1               5                   10                  15      


Phe Ala Phe Pro Lys Tyr Ile Thr Ile Met Glu Asn Lys Glu Lys Pro 
            20                  25                  30          


Glu Pro Ile Tyr Tyr Glu Leu Thr Asp Lys His Phe Trp Ala Ala Phe 
        35                  40                  45              


Leu Asn Leu Ala Arg His Asn Val Tyr Thr Thr Val Asn His Ile Asn 
    50                  55                  60                  


Lys Leu Leu Glu Ile Ala Glu Leu Lys Asn Asp Glu Asp Val Leu Asn 
65                  70                  75                  80  


Ile Lys Asp Ser Trp Asn Lys Gln Ala Glu Lys Leu Asp Lys Lys Val 
                85                  90                  95      


Arg Leu Arg Asn Leu Leu Met Arg His Phe Pro Phe Leu Glu Ala Ala 
            100                 105                 110         


Ala Tyr Lys Lys Thr Thr Ser Lys Asp Ser Asn Ser Lys Glu Gln Lys 
        115                 120                 125             


Glu Lys Glu Gln Ala Glu Ala Leu Ser Leu Asp Asn Leu Lys Asn Val 
    130                 135                 140                 


Leu Phe Ile Phe Leu Glu Lys Leu Gln Ser Leu Arg Asn Tyr Tyr Ser 
145                 150                 155                 160 


His Tyr Lys Tyr Ser Glu Glu Ala Gln Lys Pro Thr Phe Glu Asn Asp 
                165                 170                 175     


Leu Leu Lys Asn Met Tyr Lys Ile Phe Asp Thr Asn Val Arg Leu Val 
            180                 185                 190         


Lys Arg Asp Tyr Met His His Glu Asn Val Asp Met Gln Arg Asp Phe 
        195                 200                 205             


Ser His Leu Asn Arg Lys Arg Gln Glu Gly Gln Thr Arg Lys Ile Ile 
    210                 215                 220                 


Ala Asn Pro Asn Phe Arg Tyr His Phe Ala Asp Glu Lys Gly Asp Met 
225                 230                 235                 240 


Thr Ile Ala Gly Leu Leu Phe Phe Ile Ser Leu Phe Leu Asp Lys Lys 
                245                 250                 255     


Asp Ala Ile Trp Met Gln Lys Lys Leu Lys Gly Phe Lys Asp Gly Arg 
            260                 265                 270         


Asn Leu Arg Glu Gln Met Thr Asn Glu Val Phe Cys Arg Ser Arg Ile 
        275                 280                 285             


Ser Leu Pro Lys Leu Lys Leu Glu Asn Val Gln Thr Lys Asp Trp Met 
    290                 295                 300                 


Gln Leu Asp Met Leu Asn Glu Leu Val Arg Cys Pro Lys Ser Leu Tyr 
305                 310                 315                 320 


Glu Arg Leu Arg Glu Lys Asp Arg Glu Ser Phe Lys Val Pro Phe Asp 
                325                 330                 335     


Ile Phe Ser Asp Asp Tyr Asp Ala Glu Glu Glu Pro Phe Lys Asn Thr 
            340                 345                 350         


Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Val Phe Arg Tyr Phe 
        355                 360                 365             


Asp Leu Asn Glu Ile Phe Glu Gln Leu Arg Phe Gln Ile Asp Leu Gly 
    370                 375                 380                 


Thr Tyr His Phe Ser Ile Tyr Asn Lys Leu Ile Gly Asp Glu Asp Glu 
385                 390                 395                 400 


Val Arg His Leu Thr His His Leu Tyr Gly Phe Ala Arg Ile Gln Asp 
                405                 410                 415     


Phe Ala Pro Gln Asn Gln Pro Glu Glu Trp Arg Lys Leu Val Lys Asp 
            420                 425                 430         


Leu Asp His Phe Glu Thr Ser Gln Lys Pro Tyr Ile Ser Lys Thr Ala 
        435                 440                 445             


Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Lys Phe Cys Ser 
    450                 455                 460                 


Thr His Asn Lys Leu Phe Pro Ser Leu Lys Arg Glu Lys Thr Cys Asn 
465                 470                 475                 480 


Gly Arg Ser Lys Phe Asn Leu Gly Thr Gln Phe Thr Ala Glu Ala Phe 
                485                 490                 495     


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu 
            500                 505                 510         


Thr Lys Asp Tyr Ser Arg Lys Glu Ser Ala Asp Lys Val Glu Gly Ile 
        515                 520                 525             


Ile Arg Lys Glu Ile Ser Asn Ile Tyr Ala Ile Tyr Asp Ala Phe Ala 
    530                 535                 540                 


Asn Asn Glu Ile Asn Ser Ile Ala Asp Leu Thr Gly Arg Leu Gln Lys 
545                 550                 555                 560 


Thr Asn Ile Leu Gln Gly His Leu Pro Lys Gln Met Ile Ser Ile Leu 
                565                 570                 575     


Glu Gly Arg Gln Lys Asp Met Glu Lys Glu Ala Glu Arg Lys Ile Gly 
            580                 585                 590         


Glu Met Ile Asp Asp Thr Gln Arg Arg Leu Asp Leu Leu Cys Lys Gln 
        595                 600                 605             


Thr Asn Gln Lys Ile Arg Ile Gly Lys Arg Asn Ala Gly Leu Leu Lys 
    610                 615                 620                 


Ser Gly Lys Ile Ala Asp Trp Leu Val Ser Asp Met Met Arg Phe Gln 
625                 630                 635                 640 


Pro Val Gln Lys Asp Thr Asn Asn Ala Pro Ile Asn Asn Ser Lys Ala 
                645                 650                 655     


Asn Ser Thr Glu Tyr Arg Met Leu Gln His Ala Leu Ala Leu Phe Gly 
            660                 665                 670         


Ser Glu Ser Ser Arg Leu Lys Ala Tyr Phe Arg Gln Met Asn Leu Val 
        675                 680                 685             


Gly Asn Ala Asn Pro His Pro Phe Leu Ala Glu Thr Gln Trp Glu His 
    690                 695                 700                 


Gln Thr Asn Ile Leu Ser Phe Tyr Arg Asn Tyr Leu Glu Ala Arg Lys 
705                 710                 715                 720 


Lys Tyr Leu Lys Gly Leu Lys Pro Gln Asn Trp Lys Gln Tyr Gln His 
                725                 730                 735     


Phe Leu Ile Leu Lys Val Gln Lys Thr Asn Arg Asn Thr Leu Val Thr 
            740                 745                 750         


Gly Trp Lys Asn Ser Phe Asn Leu Pro Arg Gly Ile Phe Thr Gln Pro 
        755                 760                 765             


Ile Arg Glu Trp Phe Glu Lys His Asn Asn Ser Lys Arg Ile Tyr Asp 
    770                 775                 780                 


Gln Ile Leu Ser Phe Asp Arg Val Gly Phe Val Ala Lys Ala Ile Pro 
785                 790                 795                 800 


Leu Tyr Phe Ala Gly Glu Tyr Lys Asp Asn Val Gln Pro Phe Tyr Asp 
                805                 810                 815     


Tyr Pro Phe Asn Ile Gly Asn Lys Leu Lys Pro Gln Lys Gly Gln Phe 
            820                 825                 830         


Leu Asp Lys Lys Glu Arg Val Glu Leu Trp Gln Lys Asn Lys Glu Leu 
        835                 840                 845             


Phe Lys Asn Tyr Pro Pro Glu Lys Arg Lys Thr Asp Leu Ala Tyr Leu 
    850                 855                 860                 


Asp Phe Leu Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys 
865                 870                 875                 880 


Asn Gln Asp Ile Val Thr Trp Leu Met Phe Lys Glu Leu Phe Lys Thr 
                885                 890                 895     


Thr Thr Val Glu Gly Leu Lys Ile Gly Glu Ile His Leu Arg Asp Ile 
            900                 905                 910         


Asp Thr Asn Thr Ala Asn Glu Glu Ser Asn Asn Ile Leu Asn Arg Ile 
        915                 920                 925             


Met Pro Met Lys Leu Pro Val Lys Thr Tyr Glu Thr Asp Asn Lys Gly 
    930                 935                 940                 


Asn Ile Leu Lys Glu Arg Pro Leu Ala Thr Phe Tyr Ile Glu Glu Thr 
945                 950                 955                 960 


Glu Thr Lys Val Leu Lys Gln Gly Asn Phe Lys Val Leu Ala Lys Asp 
                965                 970                 975     


Arg Arg Leu Asn Gly Leu Leu Ser Phe Ala Glu Thr Thr Asp Ile Asp 
            980                 985                 990         


Leu Glu Lys Asn Pro Ile Thr Lys  Leu Ser Val Asp His  Glu Leu Ile 
        995                 1000                 1005             


Lys Tyr  Gln Thr Thr Arg Ile  Ser Ile Phe Glu Met  Thr Leu Gly 
    1010                 1015                 1020             


Leu Glu  Lys Lys Leu Ile Asp  Lys Tyr Ser Thr Leu  Pro Thr Asp 
    1025                 1030                 1035             


Ser Phe  Arg Asn Met Leu Glu  Arg Trp Leu Gln Cys  Lys Ala Asn 
    1040                 1045                 1050             


Arg Pro  Glu Leu Lys Asn Tyr  Val Asn Ser Leu Ile  Ala Val Arg 
    1055                 1060                 1065             


Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met Tyr Asp  Ala Thr Leu 
    1070                 1075                 1080             


Phe Ala  Glu Val Lys Lys Phe  Thr Leu Phe Pro Ser  Val Asp Thr 
    1085                 1090                 1095             


Lys Lys  Ile Glu Leu Asn Ile  Ala Pro Gln Leu Leu  Glu Ile Val 
    1100                 1105                 1110             


Gly Lys  Ala Ile Lys Glu Ile  Glu Lys Ser Glu Asn  Lys Asn 
    1115                 1120                 1125         


<210>  2663
<211>  1120
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2663

Met Glu Asp Asp Lys Lys Thr Thr Asp Ser Ile Arg Tyr Glu Leu Lys 
1               5                   10                  15      


Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val 
            20                  25                  30          


Tyr Leu Thr Val Asn His Ile Asn Lys Ile Leu Glu Glu Asp Glu Ile 
        35                  40                  45              


Asn Arg Asp Gly Tyr Glu Asn Thr Leu Glu Asn Ser Trp Asn Glu Ile 
    50                  55                  60                  


Lys Asp Ile Asn Lys Lys Asp Arg Leu Ser Lys Leu Ile Ile Lys His 
65                  70                  75                  80  


Phe Pro Phe Leu Glu Ala Thr Thr Tyr Arg Gln Asn Pro Thr Asp Thr 
                85                  90                  95      


Thr Lys Gln Lys Glu Glu Lys Gln Ala Glu Ala Gln Ser Leu Glu Ser 
            100                 105                 110         


Leu Lys Lys Ser Phe Phe Val Phe Ile Tyr Lys Leu Arg Asp Leu Arg 
        115                 120                 125             


Asn His Tyr Ser His Tyr Lys His Ser Lys Ser Leu Glu Arg Pro Lys 
    130                 135                 140                 


Phe Glu Glu Asp Leu Gln Asn Lys Met Tyr Asn Ile Phe Asp Val Ser 
145                 150                 155                 160 


Ile Gln Phe Val Lys Glu Asp Tyr Lys His Asn Thr Asp Ile Asn Pro 
                165                 170                 175     


Lys Lys Asp Phe Lys His Leu Asp Arg Lys Arg Lys Gly Lys Phe His 
            180                 185                 190         


Tyr Ser Phe Ala Asp Asn Glu Gly Asn Ile Thr Glu Ser Gly Leu Leu 
        195                 200                 205             


Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Val Gln 
    210                 215                 220                 


Lys Lys Leu Glu Gly Phe Lys Cys Ser Asn Lys Ser Tyr Gln Lys Met 
225                 230                 235                 240 


Thr Asn Glu Val Phe Cys Arg Ser Arg Met Leu Leu Pro Lys Leu Arg 
                245                 250                 255     


Leu Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu Asn 
            260                 265                 270         


Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Gln Arg Ala 
        275                 280                 285             


Tyr Arg Glu Lys Phe Lys Val Pro Phe Asp Ser Ile Asp Glu Asp Tyr 
    290                 295                 300                 


Asp Ala Glu Gln Glu Pro Phe Arg Asn Thr Leu Val Arg His Gln Asp 
305                 310                 315                 320 


Arg Phe Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Tyr Asn Glu Val Phe 
                325                 330                 335     


Ala Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile 
            340                 345                 350         


Tyr Lys Lys Leu Ile Gly Asp Asn Lys Glu Asp Arg His Leu Thr His 
        355                 360                 365             


Lys Leu Tyr Gly Phe Glu Arg Ile Gln Glu Phe Asp Lys Gln Asn Arg 
    370                 375                 380                 


Pro Asp Glu Trp Lys Ala Ile Val Lys Asp Ser Asp Thr Phe Lys Lys 
385                 390                 395                 400 


Lys Glu Glu Lys Glu Glu Glu Lys Pro Tyr Ile Ser Glu Thr Thr Pro 
                405                 410                 415     


His Tyr His Leu Glu Asn Lys Lys Ile Gly Ile Ala Phe Lys Asn His 
            420                 425                 430         


Asn Ile Trp Pro Ser Thr Gln Thr Glu Leu Thr Asn Asn Lys Arg Lys 
        435                 440                 445             


Lys Tyr Asn Leu Gly Thr Ser Ile Lys Ala Glu Ala Phe Leu Ser Val 
    450                 455                 460                 


His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Lys Thr Glu 
465                 470                 475                 480 


Asn Thr Lys Asn Asp Asn Lys Val Gly Gly Lys Lys Glu Thr Lys Lys 
                485                 490                 495     


Gln Gly Lys His Lys Ile Glu Ala Ile Ile Glu Ser Lys Ile Lys Asp 
            500                 505                 510         


Ile Tyr Ala Leu Tyr Asp Ala Phe Ala Asn Gly Glu Ile Asn Ser Glu 
        515                 520                 525             


Asp Glu Leu Lys Glu Tyr Leu Lys Gly Lys Asp Ile Lys Ile Val His 
    530                 535                 540                 


Leu Pro Lys Gln Met Ile Ala Ile Leu Lys Asn Glu His Lys Asp Met 
545                 550                 555                 560 


Ala Glu Lys Ala Glu Asp Lys Gln Glu Lys Met Lys Leu Ala Thr Glu 
                565                 570                 575     


Asn Arg Leu Lys Thr Leu Asp Lys Gln Leu Lys Gly Lys Ile Gln Asn 
            580                 585                 590         


Gly Lys Arg Tyr Asn Ser Ala Pro Lys Ser Gly Glu Ile Ala Ser Trp 
        595                 600                 605             


Leu Val Asn Asp Met Met Arg Phe Gln Pro Val Gln Lys Asp Asn Glu 
    610                 615                 620                 


Gly Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln Leu 
625                 630                 635                 640 


Leu Gln Arg Thr Leu Ala Phe Phe Gly Ser Glu His Glu Arg Leu Ala 
                645                 650                 655     


Pro Tyr Phe Lys Gln Thr Lys Leu Ile Glu Ser Ser Asn Pro His Pro 
            660                 665                 670         


Phe Leu Asn Asp Thr Glu Trp Glu Lys Cys Asn Asn Ile Leu Ser Phe 
        675                 680                 685             


Tyr Arg Ser Tyr Leu Thr Lys Lys Ile Glu Phe Leu Asn Lys Leu Lys 
    690                 695                 700                 


Pro Glu Asp Trp Glu Lys Asn Gln Tyr Phe Leu Met Leu Lys Gly Pro 
705                 710                 715                 720 


Lys Ile Asn Arg Lys Thr Leu Val Gln Gly Trp Lys Asn Gly Phe Asn 
                725                 730                 735     


Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg Lys Trp Phe Met Glu 
            740                 745                 750         


His Trp Lys Asn Ile Lys Val Asp Asp Ser Lys Arg Val Gly Leu Val 
        755                 760                 765             


Ala Lys Val Ile Pro Leu Phe Phe Ser Glu Lys Tyr Lys Asp Ser Val 
    770                 775                 780                 


Gln Pro Phe Tyr Asn Tyr Pro Phe Asn Val Gly Asp Val Asn Lys Pro 
785                 790                 795                 800 


Lys Glu Glu Asp Phe Leu His Arg Glu Glu Arg Ile Glu Leu Trp Asp 
                805                 810                 815     


Lys Lys Lys Asp Lys Phe Lys Gly Tyr Lys Ala Lys Glu Lys Ser Lys 
            820                 825                 830         


Lys Met Thr Asp Lys Glu Lys Glu Glu His Arg Ser Tyr Leu Glu Phe 
        835                 840                 845             


Gln Ser Trp Asn Lys Phe Glu Arg Glu Leu Arg Leu Val Arg Asn Gln 
    850                 855                 860                 


Asp Ile Val Thr Trp Leu Leu Cys Thr Glu Leu Ile Asp Lys Leu Lys 
865                 870                 875                 880 


Ile Asp Glu Leu Asn Ile Lys Glu Leu Lys Lys Leu Arg Leu Lys Asp 
                885                 890                 895     


Ile Asp Thr Asp Thr Ala Lys Lys Glu Lys Asn Asn Ile Leu Asn Arg 
            900                 905                 910         


Val Met Pro Met Glu Leu Pro Val Thr Val Tyr Glu Val Asn Gln Gly 
        915                 920                 925             


Gly Tyr Ile Ile Lys Asn Lys Pro Leu His Thr Ile Tyr Ile Lys Glu 
    930                 935                 940                 


Ala Glu Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys 
945                 950                 955                 960 


Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe Val Lys Thr Pro Ser Glu 
                965                 970                 975     


Ala Glu Ser Glu Ser Asn Pro Ile Ser Lys Ser Arg Val Glu Ser Glu 
            980                 985                 990         


Leu Gly Lys Tyr Gln Asn Ala Arg  Leu Asp Ile Ile Lys  Asp Met Leu 
        995                 1000                 1005             


Ala Leu  Glu Lys Lys Leu Ile  Asp Lys Tyr Asn Ser  Leu Asp Thr 
    1010                 1015                 1020             


Asp Asn  Phe His Asn Met Leu  Thr Gly Trp Leu Glu  Leu Lys Gly 
    1025                 1030                 1035             


Glu Ala  Lys Lys Ala Arg Phe  Gln Asn Asp Val Asp  Leu Leu Val 
    1040                 1045                 1050             


Ala Val  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Met Tyr Asp 
    1055                 1060                 1065             


Glu Asn  Leu Phe Gly Asn Ile  Glu Arg Phe Ser Leu  Ser Ser Ser 
    1070                 1075                 1080             


Asn Ile  Ile Glu Ser Lys Gly  Leu Asp Ile Ala Val  Lys Leu Lys 
    1085                 1090                 1095             


Glu Glu  Val Ser Lys Ala Val  Glu Lys Ile Gln Asn  Glu Glu Asp 
    1100                 1105                 1110             


Asn Lys  Lys Glu Lys Glu Thr  
    1115                 1120 


<210>  2664
<211>  1174
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2664

Met Ala Phe Ser Ser Lys Gln Leu Glu Gln His Ile Leu Ala Ser Tyr 
1               5                   10                  15      


Tyr Asn Asp Ala Arg Leu Asn Ile Leu Ala Cys Leu Asn Asp Ile Arg 
            20                  25                  30          


Glu Lys Ser Gly Lys Arg Pro Ile Glu Asn Glu Asp Gln Ile Lys His 
        35                  40                  45              


Ala Phe Thr Asp Leu Ala Leu Ser Lys Ala Thr Pro Glu Arg Gln Thr 
    50                  55                  60                  


Glu Leu Ile Lys Gln Leu Arg His Arg Phe His Phe Leu Asp Leu Leu 
65                  70                  75                  80  


Thr Asp Ala Ser Pro Gln Val Ser Gln Lys Lys Lys Gln Asp Asn Ala 
                85                  90                  95      


Thr Pro Leu Pro His Tyr Tyr Glu Ser His Leu Thr Trp Met Leu Glu 
            100                 105                 110         


Leu Val Asn Gly Leu Arg Asn Thr Met Ala His Pro Val Asp Lys Glu 
        115                 120                 125             


Ile Thr Ile Ala Tyr Ala Ile His Lys Lys Leu Tyr Phe Ala Leu Ser 
    130                 135                 140                 


Lys Leu Tyr Asp Ser Ser Phe His Thr Ile Lys Thr Arg Phe Ser His 
145                 150                 155                 160 


Glu Thr Asn Ala Met Gln Pro Phe Gln Arg Cys Asp Ser Lys Gly Lys 
                165                 170                 175     


Pro Lys Ser Ala Lys Gln Phe Ala Phe Ala Leu Cys Thr Asp Pro Leu 
            180                 185                 190         


Asp Leu Ser Glu Ser Ser Asp Leu Pro Gln Ser Lys Val Leu His Asp 
        195                 200                 205             


Phe Gly His Ile Leu Phe Cys Ser Leu Phe Leu Glu Lys Ser Gln Ser 
    210                 215                 220                 


Ala Glu Leu Ile Asn Tyr Phe Trp Gln Thr Gln Gln Gly Ser Lys Trp 
225                 230                 235                 240 


Gly Asp Thr Val Gln Arg Thr Ile Ile Arg Glu Met Ile Ala Val Tyr 
                245                 250                 255     


Arg Val Arg Leu Pro Leu Gln Arg Leu Lys Ser Asp Asp Thr Ser Thr 
            260                 265                 270         


Ala Val Thr Leu Asp Thr Leu Ser Glu Leu Ser Arg Cys Pro Arg Ala 
        275                 280                 285             


Leu Leu Asp Ala Leu Ser Pro Asp Asp Gln Ala Arg Phe Arg Gly Asp 
    290                 295                 300                 


Val Gly Ser Asn Asp Ser Thr Asp Ala Ala Asp Ala Asp Thr Ser Glu 
305                 310                 315                 320 


Asn Thr Tyr Leu Phe Ala Arg Ser Arg Gln Glu Arg Phe Ile Pro Leu 
                325                 330                 335     


Met Met Arg Phe Phe Asp Phe Asn Pro Ala Asn Lys Leu Arg Phe Ala 
            340                 345                 350         


Val Asp Leu Gly Gln Phe Tyr Tyr Asn Val Arg Leu Lys Pro Ala Ser 
        355                 360                 365             


Gln Phe Thr Asp Glu Thr Ala Arg Val Arg Arg Leu Gly Gln Lys Ile 
    370                 375                 380                 


Leu Ala Tyr Gly Arg Leu Ser Asp Phe Asp Pro Asp Asp Lys Pro Ala 
385                 390                 395                 400 


Glu Trp Gln Gln Leu Glu Asn Asn Tyr Ser Val Ser Arg Asp Glu Glu 
                405                 410                 415     


Glu Gln Thr Leu Gln Asn Ala Ser Asp Thr Ile Gln Val Leu Lys Pro 
            420                 425                 430         


Tyr Ile Val Pro Thr Tyr Pro His Tyr His Tyr Phe Asp Asp Lys Ile 
        435                 440                 445             


Gly Phe Arg Leu Glu Ser Lys Pro Ala Thr Gly Tyr Pro Asp Leu Gln 
    450                 455                 460                 


Ala Leu Ala Val Asp Ser Ala Val Ile Leu Asn Ser Pro Ala Ser Arg 
465                 470                 475                 480 


Asp Met Met Pro Glu Phe Trp Val Ser Pro Ala Gln Leu Leu Ala Leu 
                485                 490                 495     


Val Phe Tyr Ser Gln Leu Gln Pro Ala Ser Pro Asn Gln Gln Arg Tyr 
            500                 505                 510         


Leu Ala Leu Asp Ile Leu Leu Thr Lys Tyr Arg Val Gly Met Lys Asn 
        515                 520                 525             


Leu Leu Asn Ala Leu Ala His Gly Asn Val Ser Leu Ser Gly Ala Pro 
    530                 535                 540                 


His Ser Ala Glu Arg Arg Glu Gln Ala Gln Gln Trp Val Asp Lys His 
545                 550                 555                 560 


Phe Asp His Asn Ala Gly Thr Arg Phe Ala Val Pro Leu Ser His Leu 
                565                 570                 575     


Pro Lys Val Val Ile Gln His Leu Leu Gly Ala Glu Asp Arg Gln Val 
            580                 585                 590         


Ala Val Ala Glu Val Val Ala Arg Ala Glu His Val Leu Ala Glu Thr 
        595                 600                 605             


Gln His Lys Gln Asp Gln Leu Lys Gln Leu Leu Gln His Ala Asp Lys 
    610                 615                 620                 


Lys Arg Gly Gln Lys Gly Phe Lys Ala Ile Lys Cys Gly His Ile Gly 
625                 630                 635                 640 


Asp Phe Leu Thr Asp Asp Leu Met Arg Phe Gln Pro Val Asp Ala Asp 
                645                 650                 655     


Lys Ser Asp Gly Gly Lys Ile Asn Ser Gln Gln Tyr Gln Ile Leu Gln 
            660                 665                 670         


Ala Ala Leu Ala Tyr Tyr Gly Ala His Val Asn Glu Pro Pro Lys Val 
        675                 680                 685             


Val Asp Leu Leu Arg Asp Ala Gly Leu Leu His Gly Lys Phe Ala His 
    690                 695                 700                 


Pro Phe Ile Ala Asp Leu Asn Leu Glu Ser Gln Pro Asn Gln Tyr Arg 
705                 710                 715                 720 


Gly Leu Ile Ser Phe Tyr Glu Ala Tyr Leu Lys Ala Arg Ala Arg Tyr 
                725                 730                 735     


Leu Lys Ala Phe Ile Lys Glu Gln Gln Gln Arg Arg Thr Val Thr Phe 
            740                 745                 750         


Val Pro Gln Trp Leu Arg Leu Arg Gln Pro Ser Ser Leu Gln Asn Trp 
        755                 760                 765             


Leu Asn Glu Gln Arg Asp Ala Asn Gly Asn Leu Thr Gln Pro Leu Pro 
    770                 775                 780                 


Leu Met Asp Asn Met Leu Tyr Pro Pro Ile Leu Ala Leu Val Gly Glu 
785                 790                 795                 800 


Ala Leu Asp Ile Asp Pro His Thr Leu Glu Gln Glu Gly Met Gln Arg 
                805                 810                 815     


Phe Met Arg Gly Asp Glu Glu Ile Ala Ile Pro Pro Ala Val Thr Trp 
            820                 825                 830         


Leu Ile Lys Arg Tyr Leu Gly Ala Arg Gly Asp Thr Ser Gln Leu Met 
        835                 840                 845             


Tyr Gln Tyr Pro Arg His His Gly Leu Phe Asp Thr Trp Leu Asp Lys 
    850                 855                 860                 


Arg Thr Pro Lys Gln Arg Phe Gln Glu Lys Pro Thr His Tyr Leu Pro 
865                 870                 875                 880 


Glu Ala Glu Arg Gln Ala Tyr Arg Asp Glu Ile Arg His Phe Val Gln 
                885                 890                 895     


Thr Asn Thr Ser Ala Lys Gln Ala Asp Val Glu Leu Arg Glu Lys Leu 
            900                 905                 910         


Gly Lys Leu Leu Lys Ala Tyr Gln Arg Asp Glu Gln Thr Ile Arg His 
        915                 920                 925             


Ser Val Ser Gln Asp Met Leu Leu Tyr Leu Ser Ala Arg Gln Tyr Leu 
    930                 935                 940                 


Glu Ser Leu His Leu Ser Asn Gly Gly Leu Ala Ala Lys Pro Ala Trp 
945                 950                 955                 960 


Ser Leu Gln Gly Ile Glu Lys Thr Leu Leu Arg Thr Glu Ile His Tyr 
                965                 970                 975     


Ala Leu Pro Val Pro Gly Thr Asp Lys Gln Val Phe His Pro Ala Cys 
            980                 985                 990         


Lys Ile Arg Asn Leu Gly Glu Leu  Gly Leu Leu Val Arg  Asp Arg Arg 
        995                 1000                 1005             


Leu Pro  Ser Leu Leu Arg Tyr  Tyr Ser Cys Asp Glu  Asn Ala Ile 
    1010                 1015                 1020             


His His  Ala Glu Ile Arg Ala  Glu Leu Asn Ser Tyr  Arg Arg Ala 
    1025                 1030                 1035             


Lys Val  Ala Val Met Ala Met  Val His Glu Leu Glu  Lys Thr Leu 
    1040                 1045                 1050             


Leu Lys  Val Leu Gly Asp Ile  Pro Glu Arg Thr Lys  Glu Gln Glu 
    1055                 1060                 1065             


Lys Gln  Ser Lys Asp Phe Gly  Lys Gly Arg His Gly  Asp Phe Leu 
    1070                 1075                 1080             


Phe Ala  Leu Tyr Gln Gln Gln  Arg Gln Arg Thr Gly  Asn Glu Ala 
    1085                 1090                 1095             


Glu Thr  Phe Ser Pro Ala Arg  Phe Lys Arg Thr Leu  Leu Ile Arg 
    1100                 1105                 1110             


Asn Ala  Phe Ser His Asn Gln  Tyr Pro Asp Ala Ala  Ala Phe Ile 
    1115                 1120                 1125             


Pro Ile  Ala Ala Gln Val Gln  Gly Glu Ala Val Pro  Ser Asn Pro 
    1130                 1135                 1140             


Ala Asn  His Arg Lys Val Ala  Glu Arg Leu Met Gln  Glu Met Glu 
    1145                 1150                 1155             


Asn Leu  Tyr Ser Pro Trp Met  Arg Tyr Leu Arg Gln  Tyr Lys Ala 
    1160                 1165                 1170             


Glu 
    


<210>  2665
<211>  1131
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2665

Met Glu Lys Thr Ile Glu Asn Gln Thr Gln Ser Lys Arg Thr Leu Asn 
1               5                   10                  15      


Asn Thr Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Asp Glu Glu Lys Ile Thr Thr Ser Phe Leu Val Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Arg Gln Ser Leu Val Tyr Ser Asn Leu Thr 
65                  70                  75                  80  


Arg Tyr Met His Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Asp 
                85                  90                  95      


Asp Glu Arg Asp Lys Ala Glu Asn Tyr Gly Lys Asp Phe Gly Asn Leu 
            100                 105                 110         


Thr Asp Thr Leu Lys Glu Ile Phe Lys Glu Leu Asn Glu Phe Arg Asn 
        115                 120                 125             


Asp Tyr Ser His Tyr Tyr Ser Thr Glu Lys Lys Asp Lys Arg Lys Thr 
    130                 135                 140                 


Ile Val Ser Asp Lys Leu Lys Asn Phe Leu Asn Ile Asn Tyr Thr Arg 
145                 150                 155                 160 


Ala Ile Lys Tyr Thr Lys Ser Arg Phe Ile Asn Val Phe Ser Asp Asn 
                165                 170                 175     


Asn Phe Cys Leu Ala Glu Glu Ala Lys His Val Glu Asn Asp Asn Thr 
            180                 185                 190         


Ile Thr Gln Asp Gly Ile Val Phe Phe Thr Ser Met Phe Leu Asp Arg 
        195                 200                 205             


Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile Ile Gly Leu Lys Gly Thr 
    210                 215                 220                 


Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Thr Leu Met Ala Phe Cys 
225                 230                 235                 240 


Val Asn Leu Pro His Asp Lys Phe Val Ser Glu Asn Ser Glu Gln Gln 
                245                 250                 255     


Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu 
            260                 265                 270         


Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln His Phe Leu Pro Lys Leu 
        275                 280                 285             


Asp Asp Glu Gln Ile Asp Asn Val Leu Glu Asn Ser Val Pro Tyr Thr 
    290                 295                 300                 


Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn Ile Thr Lys Lys Val Arg 
305                 310                 315                 320 


Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu Lys Phe Ile Asp Gln Lys 
                325                 330                 335     


Lys Leu Phe Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val 
            340                 345                 350         


Leu Asp Glu Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Lys Arg Thr 
        355                 360                 365             


Val Thr Glu Asn Thr Lys Ala Phe Gly Met Leu Gln Asp Leu Asn Asp 
    370                 375                 380                 


Glu Glu Asn Val Leu Asn Lys Ile Asn Thr Gly Glu Ser Lys Ala Lys 
385                 390                 395                 400 


Phe Asp Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Thr Lys Asn 
            420                 425                 430         


Thr Asp Asn Lys Ile Lys Ser Asn Leu Leu Gln Pro Leu Pro Glu Ala 
        435                 440                 445             


Phe Leu Ser Ile Asn Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
    450                 455                 460                 


Glu Gln Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn 
465                 470                 475                 480 


Asn Ser Lys Ile Leu Asn Lys Glu Phe Ile Lys Ala Ile Lys Leu Lys 
                485                 490                 495     


Leu Asn Asp Leu Asp Val Phe Tyr Lys Arg Ser Gln Gly Arg Lys Gln 
            500                 505                 510         


Lys His Ala Tyr Leu Thr Lys Asp Lys Lys Tyr Asp Asn Glu Lys Ile 
        515                 520                 525             


Asn Glu Leu Lys Asn Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu 
    530                 535                 540                 


Tyr Asn Leu Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp 
545                 550                 555                 560 


Leu Asn Ile Ala Asp Val Gln Ala Lys Asn Ala Ile Ser Asp Arg Ile 
                565                 570                 575     


Lys Leu Met Lys Arg Asp Cys Ile Asn Arg Leu Lys Ser Met Lys Lys 
            580                 585                 590         


Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp 
        595                 600                 605             


Ile Val Asp Met Ile Ile Asp Glu Glu Lys Lys Lys Lys Ile Thr Ser 
    610                 615                 620                 


Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Lys 
625                 630                 635                 640 


Glu Lys Lys Glu Leu Phe Ile Leu Ile Cys Asn Asn Glu Leu Lys Leu 
                645                 650                 655     


Asn Asp Asp Asp Gly His Pro Phe Phe Lys Asn Ile Asn Phe Ser Asn 
            660                 665                 670         


Tyr Lys Tyr Thr Ser Glu Ile Tyr Gln Lys Tyr Leu Glu Glu Lys Gly 
        675                 680                 685             


His Lys Met Val Lys Glu Tyr Asn Pro Arg Lys Glu Asn Tyr Val Glu 
    690                 695                 700                 


Lys Asp Lys Ser Trp Leu Glu Ile Asn Phe Tyr Lys Lys Glu Trp Asn 
705                 710                 715                 720 


Glu Asn Ala Lys Lys Asp Leu Thr Val Val Lys Leu Pro Asp Asp Lys 
                725                 730                 735     


Ser Lys Ile Pro Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser 
            740                 745                 750         


Phe Glu Asn Trp Phe Lys Tyr Val Thr Asn Gly Lys Glu Thr Thr Asp 
        755                 760                 765             


Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp Glu Thr Leu 
    770                 775                 780                 


Lys Glu Leu Leu Lys Lys Glu Leu Ser Lys Asn Asn Ile Glu Phe Lys 
785                 790                 795                 800 


Glu Glu Asp Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Asp Lys Cys 
                805                 810                 815     


Arg Asn Asp Lys Thr Gln Lys Phe Tyr Ser Ala Glu Arg Glu Tyr Thr 
            820                 825                 830         


Phe Glu Glu Glu Lys Leu Asn Phe His Ile Asn Thr Lys Ser Lys Phe 
        835                 840                 845             


Glu Glu Tyr Ile Asn Pro Glu Phe Ala Glu Lys Val Phe Arg Leu Lys 
    850                 855                 860                 


Asn Gln Asn Arg Glu Lys Asp Asn Ile Ser Gly Arg Arg Leu Pro Pro 
865                 870                 875                 880 


Leu Lys Met Lys Glu Val Thr Lys Asn Met Val Lys Arg Ile Gly Asn 
                885                 890                 895     


Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Leu Met Leu 
            900                 905                 910         


Leu Met Phe Glu Lys Leu Val Asp Asn Asn Leu Lys Leu Lys Leu Glu 
        915                 920                 925             


Asn Val Asp Lys Leu Leu Asn Glu Ser Ile Glu Ile Asn Gln Ser Ile 
    930                 935                 940                 


Ser Gly Lys Leu Ser Phe Asp Asp Ser Gly Asp Asn Glu Asn Lys Lys 
945                 950                 955                 960 


Asp Arg Ala Ile Ile Cys Arg Asn Ile Thr Glu Thr Arg Lys Arg Lys 
                965                 970                 975     


Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Glu Glu Glu  Asn Ile Pro Ile Glu  Lys Ile Lys 
        995                 1000                 1005             


Ile Glu  Leu Asp Thr Tyr Ser  Lys Ala Lys Asp Val  Val Phe Asp 
    1010                 1015                 1020             


Leu Ile  Phe Asp Leu Glu Arg  Ala Ile Ile Asn Lys  Asp Glu Asn 
    1025                 1030                 1035             


Arg Ile  Lys Glu Leu Asn Lys  Asp Lys Asn Gly Val  Ile Gln Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Phe Trp Leu  Leu Glu Lys 
    1055                 1060                 1065             


Asn Leu  Ile Thr Glu Gln Glu  Phe Thr Phe Met Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Thr  Phe Ser His Asn Gln  Phe Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Leu Phe  Ile Lys Asn Trp Asn  Glu Asn Glu Phe Ala  Lys Gln Ile 
    1100                 1105                 1110             


Leu Asn  Val Tyr Asn Gln Lys  Asn Asn Asn Leu Ile  Lys Ser Ile 
    1115                 1120                 1125             


Lys Asp  Ile 
    1130     


<210>  2666
<211>  1131
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2666

Met Glu Lys Thr Ile Glu Asn Gln Thr Gln Ser Lys Arg Thr Leu Asn 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Asp Glu Glu Lys Ile Thr Thr Ser Phe Leu Val Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Arg Gln Ser Leu Val Tyr Ser Asn Leu Thr 
65                  70                  75                  80  


Arg Tyr Met His Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Asp 
                85                  90                  95      


Asp Glu Arg Asp Lys Ala Glu Asn Tyr Gly Lys Asp Phe Gly Asn Leu 
            100                 105                 110         


Thr Asp Thr Leu Lys Glu Ile Phe Lys Glu Leu Asn Glu Phe Arg Asn 
        115                 120                 125             


Asp Tyr Ser His Tyr Tyr Ser Thr Glu Lys Lys Asp Lys Arg Lys Thr 
    130                 135                 140                 


Ile Val Ser Asp Lys Leu Lys Asn Phe Leu Asn Ile Asn Tyr Thr Arg 
145                 150                 155                 160 


Ala Ile Lys Tyr Thr Lys Ser Arg Phe Ile Asn Val Phe Ser Asp Asn 
                165                 170                 175     


Asn Phe Cys Leu Ala Glu Glu Ala Lys His Val Glu Asn Asp Asn Thr 
            180                 185                 190         


Ile Thr Gln Asp Gly Ile Val Phe Phe Thr Ser Met Phe Leu Asp Arg 
        195                 200                 205             


Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile Ile Gly Leu Lys Gly Thr 
    210                 215                 220                 


Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Thr Leu Met Ala Phe Cys 
225                 230                 235                 240 


Val Asn Leu Pro His Asp Lys Phe Val Ser Glu Asn Ser Glu Gln Gln 
                245                 250                 255     


Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu 
            260                 265                 270         


Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln His Phe Leu Pro Lys Leu 
        275                 280                 285             


Asp Asp Glu Gln Ile Asp Asn Val Leu Glu Asn Ser Val Pro Tyr Thr 
    290                 295                 300                 


Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn Ile Thr Lys Lys Val Arg 
305                 310                 315                 320 


Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu Lys Phe Ile Asp Gln Lys 
                325                 330                 335     


Lys Leu Phe Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val 
            340                 345                 350         


Leu Asp Glu Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Lys Arg Thr 
        355                 360                 365             


Val Thr Glu Asn Thr Lys Ala Phe Gly Met Leu Gln Asp Leu Asn Asp 
    370                 375                 380                 


Glu Glu Asn Val Leu Asn Lys Ile Asn Thr Gly Glu Ser Lys Ala Lys 
385                 390                 395                 400 


Phe Asp Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Thr Lys Asn 
            420                 425                 430         


Thr Asp Asn Lys Ile Lys Ser Asn Leu Leu Gln Pro Leu Pro Glu Ala 
        435                 440                 445             


Phe Leu Ser Ile Asn Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
    450                 455                 460                 


Glu Gln Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn 
465                 470                 475                 480 


Asn Ser Lys Ile Leu Asn Lys Glu Phe Ile Lys Ala Ile Lys Leu Lys 
                485                 490                 495     


Leu Asn Asp Leu Asp Val Phe Tyr Lys Arg Ser Gln Gly Arg Lys Gln 
            500                 505                 510         


Lys His Ala Tyr Leu Thr Lys Asp Lys Lys Tyr Asp Asn Glu Lys Ile 
        515                 520                 525             


Asn Glu Leu Lys Asn Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu 
    530                 535                 540                 


Tyr Asn Leu Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp 
545                 550                 555                 560 


Leu Asn Ile Ala Asp Val Gln Ala Lys Asn Ala Ile Ser Asp Arg Ile 
                565                 570                 575     


Lys Leu Met Lys Arg Asp Cys Ile Asn Arg Leu Lys Ser Met Lys Lys 
            580                 585                 590         


Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp 
        595                 600                 605             


Ile Val Asp Met Ile Ile Asp Glu Glu Lys Lys Lys Lys Ile Thr Ser 
    610                 615                 620                 


Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Lys 
625                 630                 635                 640 


Glu Lys Lys Glu Leu Phe Ile Leu Ile Cys Asn Asn Glu Leu Lys Leu 
                645                 650                 655     


Asn Asp Asp Asp Gly His Pro Phe Phe Lys Asn Ile Asn Phe Ser Asn 
            660                 665                 670         


Tyr Lys Tyr Thr Ser Glu Ile Tyr Gln Lys Tyr Leu Glu Glu Lys Gly 
        675                 680                 685             


His Lys Met Val Lys Glu Tyr Asn Pro Arg Lys Glu Asn Tyr Val Glu 
    690                 695                 700                 


Lys Asp Lys Ser Trp Leu Glu Ile Asn Phe Tyr Lys Lys Glu Trp Asn 
705                 710                 715                 720 


Glu Asn Ala Lys Lys Asp Leu Thr Val Val Lys Leu Pro Asp Asp Lys 
                725                 730                 735     


Ser Lys Ile Pro Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser 
            740                 745                 750         


Phe Glu Asn Trp Phe Lys Tyr Val Thr Asn Gly Lys Glu Thr Thr Asp 
        755                 760                 765             


Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp Glu Thr Leu 
    770                 775                 780                 


Lys Glu Leu Leu Lys Lys Glu Leu Ser Lys Asn Asn Ile Glu Phe Lys 
785                 790                 795                 800 


Glu Glu Asp Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Asp Lys Cys 
                805                 810                 815     


Arg Asn Asp Lys Thr Gln Lys Phe Tyr Ser Ala Glu Arg Glu Tyr Thr 
            820                 825                 830         


Phe Glu Glu Glu Lys Leu Asn Phe His Ile Asn Thr Lys Ser Lys Phe 
        835                 840                 845             


Glu Glu Tyr Ile Asn Pro Glu Phe Ala Glu Lys Val Phe Arg Leu Lys 
    850                 855                 860                 


Asn Gln Asn Arg Glu Lys Asp Asn Ile Ser Gly Arg Arg Leu Pro Pro 
865                 870                 875                 880 


Leu Lys Met Lys Glu Val Thr Lys Asn Met Val Lys Arg Ile Gly Asn 
                885                 890                 895     


Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Leu Met Leu 
            900                 905                 910         


Leu Met Phe Glu Lys Leu Val Asp Asn Asn Leu Lys Leu Lys Leu Glu 
        915                 920                 925             


Asn Val Asp Lys Leu Leu Asn Glu Ser Ile Glu Ile Asn Gln Ser Ile 
    930                 935                 940                 


Ser Gly Lys Leu Ser Phe Asn Asp Ser Gly Asp Asn Glu Asn Lys Lys 
945                 950                 955                 960 


Asp Arg Ala Ile Ile Cys Arg Asn Ile Thr Glu Thr Arg Lys Arg Lys 
                965                 970                 975     


Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Glu Glu Glu  Asn Ile Pro Ile Glu  Lys Ile Lys 
        995                 1000                 1005             


Ile Glu  Leu Asp Thr Tyr Ser  Lys Ala Lys Asp Val  Val Phe Asp 
    1010                 1015                 1020             


Leu Ile  Phe Asp Leu Glu Arg  Ala Ile Ile Asn Lys  Asp Glu Asn 
    1025                 1030                 1035             


Arg Ile  Lys Glu Leu Asn Lys  Asp Lys Asn Gly Val  Ile Gln Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Phe Trp Leu  Leu Glu Lys 
    1055                 1060                 1065             


Asn Leu  Ile Thr Glu Gln Glu  Phe Thr Phe Met Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Thr  Phe Ser His Asn Gln  Phe Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Leu Phe  Ile Lys Asn Trp Asn  Glu Asn Glu Phe Ala  Lys Gln Ile 
    1100                 1105                 1110             


Leu Asn  Val Tyr Asn Gln Lys  Asn Asn Asn Leu Ile  Lys Ser Ile 
    1115                 1120                 1125             


Lys Asp  Ile 
    1130     


<210>  2667
<211>  1124
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2667

Met Thr Leu Pro Ile Asn Asn Thr Phe Thr Ser Arg Ala Asp Arg Glu 
1               5                   10                  15      


Ile Leu Ser Gln Asn Lys Leu Phe Phe Gly Thr Tyr Leu Asn Met Ala 
            20                  25                  30          


Gln His Asn Thr Phe Leu Met Leu Thr Asp Ser Ser Glu Lys Val Gly 
        35                  40                  45              


Lys Thr Pro Pro Ser Ser Glu Gly Leu Trp Lys Asp Ala Gly Thr Phe 
    50                  55                  60                  


Ser Leu Leu Asn Thr Gln Gln Arg Pro Ser Ile Arg Ser Lys Ala Gly 
65                  70                  75                  80  


Arg Leu Ala Val Lys Gln Phe Val Ala Leu Glu Ser Leu Val Ile Glu 
                85                  90                  95      


Arg Glu Glu Gly Glu Ala Glu Thr Pro Pro Asp Val Glu Lys Leu His 
            100                 105                 110         


Asp Phe Leu Tyr Ser Ala Leu Glu Leu Leu Asn Asn Leu Arg Arg Glu 
        115                 120                 125             


Tyr Ser His Tyr Tyr His Glu Thr Ala Gln Asn Ile Asp Tyr Pro Lys 
    130                 135                 140                 


Leu Glu Ala Ile Phe Arg Glu Ala Lys Arg Val Ala Ile Glu Arg Leu 
145                 150                 155                 160 


Pro Lys Asp Asp Asp Lys Ala Lys Asn Lys Ala Glu Lys Lys Ile Val 
                165                 170                 175     


Lys Tyr Met Leu Arg Asn Glu Asp Glu Lys Leu Val Phe Phe Ile Ser 
            180                 185                 190         


Leu Phe Leu Ser Arg Gln Gln Ala Glu Ala Phe Met Ser Gln Ile Asn 
        195                 200                 205             


Asp Phe Lys Gly Glu His Asn Ala Leu Lys Arg Arg Val Phe Ala Gln 
    210                 215                 220                 


Leu Cys Cys Arg Leu Pro Arg Pro Lys Leu Glu Ser Ala Ala Leu Glu 
225                 230                 235                 240 


Leu Asp Ala Leu Asn Glu Leu Ala Arg Cys Pro Asp Glu Val Phe Arg 
                245                 250                 255     


Tyr Leu Asn Thr Glu Asp Lys Asn Arg Phe Val Val Pro Leu Lys Glu 
            260                 265                 270         


Leu Asp Lys Asp Asp Thr Ser Gly Asn Thr Ile Thr Leu Lys Arg Tyr 
        275                 280                 285             


Glu Asp Arg Leu Pro Tyr Leu Leu Met Arg Tyr Leu Asp Glu His Ala 
    290                 295                 300                 


Glu Asn Phe Gly Ile His Phe Gln Ile Trp Ala Gly Lys Leu Arg Thr 
305                 310                 315                 320 


Ala Asp Tyr Pro Lys Thr Ile Tyr Asp Ile Glu Asp Asn Arg Asn Ile 
                325                 330                 335     


His Glu Asn Leu Thr Ala Tyr Asp Thr Leu Gln Asn Leu Arg Asn Gly 
            340                 345                 350         


Asp Asn Ile Pro Asp Asn Trp Lys Met Gln Asp Gly Glu Leu Leu Thr 
        355                 360                 365             


Lys Ile Glu Gln Phe Ser Pro His Tyr Asn Ile Ile Asn Asn Arg Ile 
    370                 375                 380                 


Ala Leu Lys Leu Gly Asp Thr Ala Tyr Thr Glu Ile Tyr Pro Leu Ser 
385                 390                 395                 400 


Glu Asp Ser Lys Leu Asp Phe Arg Val Lys Asn Pro Leu Pro Asp Leu 
                405                 410                 415     


Ile Ile Ser Thr Tyr Asp Ile Pro Asn Leu Phe Leu Tyr Gln Tyr Leu 
            420                 425                 430         


His Gln Gln Gly Lys Ile Arg Leu Arg Pro Asp Ile Phe Ile Arg Gln 
        435                 440                 445             


Phe Ser Gly Lys Leu Arg Lys Val Phe Lys Asp Val Gln Ser Gly Glu 
    450                 455                 460                 


Leu Lys Pro Leu Gln Ala Glu Ala Phe Glu Lys Gln Gln Arg Tyr Ser 
465                 470                 475                 480 


Glu Arg Arg Gln Glu Ile Leu Glu Glu Arg Arg Ser Gln Leu Gln Ala 
                485                 490                 495     


Ile Leu Asp Asn Lys Tyr Lys Leu Val Lys Val Ser His Leu Pro Asp 
            500                 505                 510         


Ala Leu Arg Glu Tyr Leu Phe Asn Tyr Lys Ala Gln Asp Phe Asn Arg 
        515                 520                 525             


Gln Val Leu His Lys Ile Thr Glu Arg Met Glu Ala Asp Trp Gln Arg 
    530                 535                 540                 


Lys Lys Lys Ala Glu Tyr Gly Ser Gly Thr Asp Glu Pro Glu Leu Lys 
545                 550                 555                 560 


Ala Gly Asn Ile Gly Thr Tyr Ile Ala Arg Asp Ile Val Ala Leu Gln 
                565                 570                 575     


Pro Pro Asn Pro Gln Glu Val Asn Leu Gly Lys Pro Asn Asn Asp Gln 
            580                 585                 590         


Tyr Asn Glu Leu Gln Glu Ser Ile Ala Tyr Phe Gly Arg Glu Tyr His 
        595                 600                 605             


Val Leu Pro Ala Tyr Leu Arg Lys Glu Leu Gly Val Met Gly Glu Arg 
    610                 615                 620                 


Asn Asp Lys Thr Lys His Pro Phe Leu Val His Leu Asn Trp Asn Lys 
625                 630                 635                 640 


Cys His Thr Ala Lys Glu Phe Tyr Ile Glu Tyr Leu Asp Val Lys Arg 
                645                 650                 655     


Arg Trp Met Arg Ala Val Arg Asp Asp Ile Lys Ala Val Ser Pro Gln 
            660                 665                 670         


Thr Glu Gln Pro His Phe Val Lys Met Gln Arg Asn Ala Lys His Phe 
        675                 680                 685             


Gly Ile Asn Ile Asn Lys Ser Ala Leu Thr Asp Glu Gln Ile Gln Glu 
    690                 695                 700                 


Arg Tyr Gly Tyr Phe Leu Arg Ile Asn Ser Lys Ala Ala Lys Asp Arg 
705                 710                 715                 720 


Asn Tyr Leu Lys Thr Met Arg Lys Asn Pro Ile Ser Gly Asp Phe Glu 
                725                 730                 735     


Pro Thr Asp Asn Ala Pro Ile Met Leu Pro Arg Gly Ile Phe Asn Asp 
            740                 745                 750         


Ala Ile Arg Glu Ala Leu Arg Thr Asn Tyr Pro Asp Gln Ile Asn Asp 
        755                 760                 765             


Lys Ser Gly Met Ser Asp Phe Thr Arg Ile Met Ala Asn Asp Glu Asp 
    770                 775                 780                 


Leu Gln Thr Cys Tyr Ser Tyr Pro Arg His Tyr Arg Tyr Glu Ala Asp 
785                 790                 795                 800 


Asn Asp Lys Leu Phe Lys Asn Asp Arg Glu Lys Ala Arg His Thr Ile 
                805                 810                 815     


Asp Ile Lys Gly Asp Thr Ala Gln Ile Trp Gln Gly Leu Cys Asp Leu 
            820                 825                 830         


Lys Thr Glu Leu Lys Asp Asn Leu Thr Arg Ala Lys Asn Ser Gln Leu 
        835                 840                 845             


Lys Arg Leu Phe Glu Gln Val Asp Arg Gln Lys Lys Leu Trp Arg Arg 
    850                 855                 860                 


Ile Phe Arg Asn Glu Gln Ala Ile Arg Thr Val Ala Phe Lys Asp Arg 
865                 870                 875                 880 


Leu Val Trp Leu Met Val Lys Asp Ile Leu Thr Arg Lys Ser Gln Ala 
                885                 890                 895     


Glu Gln Ser Asn Leu Gln Leu Glu Gln Trp Gln Leu Gln Asp Thr Gly 
            900                 905                 910         


Phe Asp Val Arg Lys Thr Glu Val Trp Ile Leu Asp Gln Ala Ile Pro 
        915                 920                 925             


Thr Ser Leu Thr Ile His Asp Lys Asp Ile Cys Ala Asn Phe Gln Ser 
    930                 935                 940                 


Ala Glu Leu Asp Lys Ala Arg Glu Asn Glu Leu Pro Val Lys Arg Tyr 
945                 950                 955                 960 


Gly Glu Phe Arg Lys Met Leu Lys Asp Arg Arg Leu Phe Val Ala Asn 
                965                 970                 975     


Asn Ser Gly Leu Leu Arg Tyr Tyr Pro Glu Lys Ser Ile Leu Trp Thr 
            980                 985                 990         


Thr Leu Gln Asp Glu Leu Arg Asp  Tyr Asp Gln Cys Arg  Ala Glu Leu 
        995                 1000                 1005             


Leu Asn  Ala Ile Phe Ala Phe  Glu Gln Arg Val Leu  Ser Asn Gln 
    1010                 1015                 1020             


Gln Cys  Arg Gln His Leu Ser  Leu Thr Glu Asn Arg  Ile Asp His 
    1025                 1030                 1035             


Lys Val  Tyr Leu Glu Ala Tyr  Lys Ala Thr Tyr Gly  Asn Met Pro 
    1040                 1045                 1050             


Gln Pro  Ile Ser Asn Ile Asn  Gln Leu Arg Asn Lys  Phe Met His 
    1055                 1060                 1065             


Asn Gln  Ile Pro Tyr Asp Thr  Trp Ile Ser Gln Ala  Ile Glu His 
    1070                 1075                 1080             


Asn Thr  Asn Ala Asn Leu Pro  Ile Glu Asp His Arg  Asn Lys Asn 
    1085                 1090                 1095             


Val Val  Lys Gln Leu Ile Glu  Phe Ala Thr Glu Leu  Tyr Asp Gly 
    1100                 1105                 1110             


Met Asn  Glu Ile Leu Phe Tyr  Asn Lys Glu Asn 
    1115                 1120                 


<210>  2668
<211>  1097
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2668

Met Glu Asn Asp Lys Lys Leu Glu Glu Ser Ala Cys Tyr Thr Leu Asn 
1               5                   10                  15      


Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val 
            20                  25                  30          


Tyr Ile Thr Val Asn His Ile Asn Lys Thr Leu Gly Glu Gly Glu Ile 
        35                  40                  45              


Asn Arg Asp Gly Tyr Glu Thr Thr Leu Glu Asn Thr Trp Asn Glu Ile 
    50                  55                  60                  


Lys Asp Ile Asn Lys Lys Ala Arg Leu Arg Glu Leu Ile Ile Lys His 
65                  70                  75                  80  


Phe Pro Phe Leu Glu Ala Ala Thr Tyr Gln Gln Arg Ser Thr Asp Ser 
                85                  90                  95      


Thr Lys Gln Lys Glu Glu Lys Gln Ala Glu Ala Gln Ser Leu Glu Ser 
            100                 105                 110         


Leu Lys His Cys Leu Phe Pro Phe Leu Lys Lys Leu Gln Lys Ser Arg 
        115                 120                 125             


Asp His Tyr Ser His Tyr Lys His Ser Lys Ser Leu Glu Arg Pro Lys 
    130                 135                 140                 


Phe Glu Glu Asp Leu Gln Lys Lys Met Tyr Asn Ile Phe Asp Val Ser 
145                 150                 155                 160 


Ile Arg Leu Val Lys Glu Asp Tyr Lys His Asn Thr Asp Ile Asn Leu 
                165                 170                 175     


Lys Glu Asp Phe Lys His Leu Asn Arg Thr Gly Lys Phe Lys Tyr Ser 
            180                 185                 190         


Phe Ala Asp Asn Lys Gly Asn Ile Thr Glu Ser Gly Leu Leu Phe Phe 
        195                 200                 205             


Ile Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp Met Gln Lys Lys 
    210                 215                 220                 


Leu Lys Gly Phe Lys Asp Ser Arg Glu Lys Tyr Gln Lys Met Thr Asn 
225                 230                 235                 240 


Glu Val Phe Cys Arg Ser Arg Ile Leu Leu Pro Lys Leu Arg Leu Glu 
                245                 250                 255     


Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met Leu Asn Glu Leu 
            260                 265                 270         


Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Arg Glu Lys Glu Arg 
        275                 280                 285             


Lys Glu Phe Lys Val Pro Ile Glu Ile Ala Asp Glu Asp Tyr Asp Ala 
    290                 295                 300                 


Glu Gln Glu Pro Phe Arg Asn Thr Leu Val Arg His Gln Asp Arg Phe 
305                 310                 315                 320 


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Tyr Asn Glu Ile Phe Thr Asn 
                325                 330                 335     


Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile Tyr Lys 
            340                 345                 350         


Lys Leu Ile Gly Gly Asn Lys Glu Asp Arg His Leu Thr His Lys Leu 
        355                 360                 365             


Tyr Gly Phe Glu Arg Ile Gln Glu Phe Ala Lys Gln Asn Arg Pro Asp 
    370                 375                 380                 


Glu Trp Lys Ala Leu Val Lys Asp Leu Asp Thr Phe Asn Lys Glu Glu 
385                 390                 395                 400 


Glu Lys Pro Tyr Ile Ser Glu Thr Thr Pro His Tyr His Leu Glu Asn 
                405                 410                 415     


Glu Lys Ile Gly Ile Val Phe Lys Asn His Asn Ile Trp Pro Ser Thr 
            420                 425                 430         


Gln Thr Glu Leu Thr Asn Asn Asn Arg Lys Lys Tyr Asn Leu Gly Val 
        435                 440                 445             


Ser Ile Lys Ala Glu Ala Phe Leu Ser Val His Glu Leu Leu Pro Met 
    450                 455                 460                 


Met Phe Tyr Tyr Leu Leu Leu Lys Thr Lys Asn Thr His Asn Gly Asn 
465                 470                 475                 480 


Glu Val Glu Ala Lys Lys Lys Gly Thr Lys Asn Lys Lys Gln Glu Lys 
                485                 490                 495     


His Lys Ile Glu Ala Ile Ile Glu Ser Lys Ile Lys Asp Ile Tyr Asn 
            500                 505                 510         


Leu Tyr Asp Ala Phe Ala Asn Gly Glu Ile Asn Ser Ile Glu Glu Leu 
        515                 520                 525             


Glu Glu His Cys Lys Gly Lys Asp Ile Glu Ile Gly His Leu Pro Lys 
    530                 535                 540                 


Gln Met Ile Ala Ile Leu Lys Asp Glu His Lys Asp Met Ala Lys Lys 
545                 550                 555                 560 


Ala Glu Thr Lys Gln Glu Lys Met Ile Leu Ala Thr Glu Asn Arg Leu 
                565                 570                 575     


Lys Thr Leu Asp Lys Lys Leu Lys Gly Lys Ile Arg Asn Gly Lys Arg 
            580                 585                 590         


Cys Asn Ser Ala Leu Lys Ser Gly Glu Ile Ala Ser Trp Leu Val Asn 
        595                 600                 605             


Asp Met Met Arg Phe Gln Pro Val Gln Arg Asp Glu Glu Gly Lys Pro 
    610                 615                 620                 


Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Gln Leu Leu Gln Arg 
625                 630                 635                 640 


Thr Leu Ala Phe Phe Gly Ser Glu His Glu Arg Leu Asp Pro Tyr Phe 
                645                 650                 655     


Lys Gln Met Asn Leu Ile Gly Asp Asn Asn Pro His Pro Phe Leu Lys 
            660                 665                 670         


Glu Thr Lys Trp Glu Glu Cys Asn Asn Ile Leu Ser Phe Tyr Arg Ser 
        675                 680                 685             


Tyr Leu Glu Ala Lys Lys Asn Phe Leu Glu Ser Leu Lys Pro Glu Asp 
    690                 695                 700                 


Trp Lys Lys Asn Gln Tyr Phe Leu Met Leu Lys Glu Pro Lys Asn Asn 
705                 710                 715                 720 


Arg Glu Thr Leu Val Gln Gly Trp Lys Asn Gly Phe Asn Leu Pro Arg 
                725                 730                 735     


Gly Ile Phe Thr Glu Pro Ile Arg Lys Trp Phe Met Glu His Arg Lys 
            740                 745                 750         


Lys Ile Lys Ala Asp Glu Leu Lys Arg Val Gly Phe Val Ala Lys Ala 
        755                 760                 765             


Ile Pro Leu Phe Phe Ser Lys Glu Tyr Lys Asp Gly Val Gln Pro Phe 
    770                 775                 780                 


Tyr Asn Tyr Pro Phe Asn Val Gly Asn Ile Asn Lys Pro Glu Glu Lys 
785                 790                 795                 800 


Asp Phe Leu Asp Tyr Glu Lys Arg Lys Lys Leu Trp Asp Lys Lys Gln 
                805                 810                 815     


Ala Lys Phe Lys Gly Lys Thr Asp Lys Glu Lys Arg Glu Asp Pro Ser 
            820                 825                 830         


Tyr Pro Asp Phe Lys Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu 
        835                 840                 845             


Val Arg Asn Gln Asp Ile Val Thr Trp Met Leu Cys Met Glu Leu Phe 
    850                 855                 860                 


Glu Glu Gln Lys Val Asp Gly Leu Asn Thr Gly Gln Ile His Leu Lys 
865                 870                 875                 880 


Asp Ile Val Thr Asn Val Asp Glu Glu Gly Asn Asn Asn Ile Leu Asn 
                885                 890                 895     


Gln Ile Lys Pro Met Gln Leu Pro Ile Thr Val Tyr Asp Lys Glu Asn 
            900                 905                 910         


Ser Pro Lys Arg Lys Pro Leu His Thr Val Tyr Ile Glu Glu Thr Gly 
        915                 920                 925             


Thr Lys Leu Leu Lys Gln Gly Asn Phe Lys Ala Leu Val Lys Asp Arg 
    930                 935                 940                 


Arg Leu Asn Gly Leu Phe Ser Phe Val Lys Thr Ser Ser Glu Ala Glu 
945                 950                 955                 960 


Ser Lys Ser Lys Pro Ile Ser Lys Ser Arg Val Glu Tyr Glu Leu Gly 
                965                 970                 975     


Ala Tyr Gln Lys Ala Arg Ile Asp Ile Ile Lys Asp Met Leu Ala Leu 
            980                 985                 990         


Glu Lys Thr Leu Ile Asp Asn Asp  Glu Asn Leu Pro Thr  Asn Lys Phe 
        995                 1000                 1005             


Ser Asp  Met Leu Lys Ser Trp  Leu Lys Gly Lys Gly  Glu Ala Asn 
    1010                 1015                 1020             


Lys Ala  Arg Phe Gln Asn Asp  Val Lys Phe Leu Ile  Ala Val Arg 
    1025                 1030                 1035             


Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met Tyr Asp  Glu Lys Leu 
    1040                 1045                 1050             


Phe Val  Asn Ile Glu Pro Phe  Ser Leu Ser Ser Ser  Asp Ile Leu 
    1055                 1060                 1065             


Glu Lys  Glu Gly Leu Arg Ile  Ala Val Gln Leu Glu  Glu Glu Val 
    1070                 1075                 1080             


Arg Lys  Ala Val Glu Lys Ile  Lys Lys Ser Glu Thr  Lys Lys 
    1085                 1090                 1095         


<210>  2669
<211>  1137
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2669

Met Glu Asn Asn Thr Thr Leu Gly Lys Gly Ile Ser Tyr Asn Pro Tyr 
1               5                   10                  15      


Lys Thr Ala Asp Lys His Tyr Phe Gly Gly Tyr Phe Asn Leu Ala Met 
            20                  25                  30          


Asn Asn Ile Glu Phe Val Ile Ala Glu Phe Leu Thr Arg Ile Gly Arg 
        35                  40                  45              


Lys Glu Thr Lys Ile Ala Asn Leu Lys Lys Val Phe Thr Glu Asn Met 
    50                  55                  60                  


Ser Leu Val Asp Tyr Glu Arg Tyr Ile His Ile Leu Glu Glu Tyr Phe 
65                  70                  75                  80  


Pro Ile Ile Lys His Leu Asp Lys Ile His Phe Lys Ile Asn Asp Thr 
                85                  90                  95      


Val Lys Glu Val Ser Lys Glu Lys Arg Ile Thr Tyr Phe Ile Asp Asn 
            100                 105                 110         


Phe Ile Ser Leu Leu Asp Leu Thr Asn Asn Leu Arg Asn Phe Tyr Thr 
        115                 120                 125             


His Tyr Tyr His Glu Ser Ile Ala Ile Glu Glu Asn Ile Phe Asp Phe 
    130                 135                 140                 


Leu Asp Glu Ser Leu Leu Thr Thr Val Arg Asp Thr Lys Glu Asn Tyr 
145                 150                 155                 160 


Leu Lys Ser Asp Lys Thr Lys Gln Ile Leu Ser Ile Ser Leu Lys Gln 
                165                 170                 175     


Glu Leu Glu Ile Leu Cys Ser Glu Lys Leu Asn Tyr Leu Lys Glu Asn 
            180                 185                 190         


Lys Ile Lys Phe Asn Arg Asn Asp Lys Glu Ala Leu Ile Asn Ala Val 
        195                 200                 205             


Tyr Asn Asp Ala Phe Lys Asn Phe Leu Tyr Lys Lys Gly Glu His Phe 
    210                 215                 220                 


His Leu Thr Asp Tyr Lys Lys Thr Lys Ile Leu Asn Pro Asp Lys Leu 
225                 230                 235                 240 


Glu Lys Asp Phe Asp Leu Asp Leu Ser Thr Ser Gly Ile Val Tyr Leu 
                245                 250                 255     


Leu Ser Phe Phe Leu Asn Arg Lys Glu Leu Glu Leu Phe Lys Gly Asn 
            260                 265                 270         


Ile Lys Gly Phe Lys Ala Ser Val Ile Arg Gly Thr Ser Asp Phe Glu 
        275                 280                 285             


Lys Asn Ser Ile His Phe Met Ala Thr His Arg Ile Tyr Ser Val His 
    290                 295                 300                 


Cys Tyr Arg Gly Leu Lys Lys Lys Ile Arg Ser Ser Asn His Asp Thr 
305                 310                 315                 320 


Lys Gln Val Leu Leu Met Gln Met Leu Asp Glu Leu Ser Lys Val Pro 
                325                 330                 335     


His Val Ile Tyr Asn Ser Leu Asp Lys Glu Leu Lys Asp Thr Phe Val 
            340                 345                 350         


Glu Asp Trp Asn Glu Tyr Phe Lys Asp Asn Glu Glu Asn Asn Glu Asn 
        355                 360                 365             


Leu Glu Asn Ser Arg Val Ile His Pro Val Ile Arg Lys Arg Tyr Glu 
    370                 375                 380                 


Asp Lys Phe Asn Tyr Phe Ala Leu Arg Phe Leu Asp Asn Cys Val Asp 
385                 390                 395                 400 


Phe Pro Thr Leu Arg Phe Gln Val His Val Gly Asp Tyr Val His His 
                405                 410                 415     


Lys Met Glu Lys Ser Leu Ile Asp Ser Lys Ile Ile Ser Glu Arg Ile 
            420                 425                 430         


Ile Lys Glu Lys Val Thr Val Phe Ala Arg Leu Asp Glu Val Asn Lys 
        435                 440                 445             


Ala Lys Ala Asp Tyr Phe Asn Ser Leu Gln Ala Glu Asn Asp Asn Arg 
    450                 455                 460                 


Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asp Phe Pro Lys Gln Asn Thr 
465                 470                 475                 480 


Glu Lys Ile Met Gly Asn Ala Lys Gln Lys Asn Ala Glu Lys Ile Gly 
                485                 490                 495     


Ile Tyr Ile Gln Leu Lys Asn Ser Asn Leu Ile Gln Gln Thr Ala Asp 
            500                 505                 510         


Ala Lys Glu Lys Leu Asn Pro His Lys Arg Ser Asn Thr Lys Leu Arg 
        515                 520                 525             


Lys Gln Glu Ile Ile Glu Lys Ile Ile Asn Leu Asn Thr Asp Tyr Lys 
    530                 535                 540                 


Ser Lys Thr Pro Ile Val His Thr Gly Glu Pro Val Ala Tyr Leu Ser 
545                 550                 555                 560 


Thr His Asp Leu His Ser Ile Leu Tyr Asp Leu Leu Ile Lys Gly Glu 
                565                 570                 575     


Thr Ala Gln Ala Val Glu Met Lys Ile Gln Lys Gln Ile Glu Lys Gln 
            580                 585                 590         


Leu Arg Glu Ile Val Asp Lys Asp Thr Ser Val Lys Ile Leu Lys Lys 
        595                 600                 605             


Tyr Asn Lys Glu Gln Thr Phe Ser Asn Ile Asn Phe Ser Lys Leu Gln 
    610                 615                 620                 


Asn Asp Leu Val Lys Glu Arg Asp Asn Leu Ile Ser Leu Leu Asp Glu 
625                 630                 635                 640 


His Asp Tyr Arg Ile Glu Asp Tyr Asp Arg Thr Lys Lys Gln Arg Asn 
                645                 650                 655     


Tyr Pro His Lys Arg Thr Tyr Ile Leu Tyr Ala Ala Glu Lys Gly Lys 
            660                 665                 670         


Ile Ala Ala Trp Leu Ala Asp Asp Ile Lys Arg Phe Met Pro Lys Asp 
        675                 680                 685             


Phe Lys Glu Gln Trp Lys Gly Tyr Gln His Ser Glu Leu Gln Lys Leu 
    690                 695                 700                 


Leu Ala Tyr Tyr Asp Thr Asn Asn Lys Leu Ile Ala Glu Leu Leu Lys 
705                 710                 715                 720 


Gly Leu Asp Ile Glu Asn Leu Pro Phe Asp Leu Asn Asn Cys Leu Lys 
                725                 730                 735     


Lys Asn Thr Leu Glu Asp Phe Tyr Pro Met Tyr Leu Glu Lys Arg Ile 
            740                 745                 750         


Gly Tyr Ile Ser Gln Leu Ile Glu Gln Ile Lys Asn Phe Lys Asp Glu 
        755                 760                 765             


Pro Lys Leu Leu Lys Lys Val Leu Asn Glu Cys Phe Lys Phe Leu Lys 
    770                 775                 780                 


Glu Lys Asn Tyr Lys Gln Cys Gly Leu Asn Asp Gln Val Gln Arg Leu 
785                 790                 795                 800 


Leu Ala Met Pro Val Phe Ile Glu Arg Gly Phe Leu Asp Glu Lys Pro 
                805                 810                 815     


Thr Met Lys Pro Asn Ile Ser Phe Asp Asp Asn Lys Glu Asp Phe Ala 
            820                 825                 830         


Glu Trp Phe Val Tyr Tyr Lys Ser Lys Asn Asn Tyr Gln Lys Phe Tyr 
        835                 840                 845             


Asp Val Glu Leu Tyr Pro Phe Leu Tyr Asn Asp Lys Lys Glu Leu Tyr 
    850                 855                 860                 


Lys Ile Gln Thr Lys Ile Lys Arg Gln Gln Lys Asn Asp Val Phe Thr 
865                 870                 875                 880 


Leu Leu Met Ser Lys Glu Leu Phe Thr Glu Ile Phe Arg Glu Glu Ala 
                885                 890                 895     


Asn Phe Thr Leu Gly Glu Leu Phe Gln Ser Arg Glu Glu Arg Leu Lys 
            900                 905                 910         


Asn Ala Gln Asn Ala Lys Glu Thr Gln Glu Arg Asn Leu Asn Phe Ile 
        915                 920                 925             


Trp Asn Lys Val Val Asn Leu Asn Leu Ala Asn Gly Lys Ile Asn Ile 
    930                 935                 940                 


Ser Asp Val Lys Leu Lys Asp Ile Gly Asn Phe Lys Ala Tyr Glu Thr 
945                 950                 955                 960 


Asp Gln Arg Val Ile Ser Phe Leu Glu Tyr Glu Thr Asn Lys Lys Trp 
                965                 970                 975     


Leu Ala Tyr Leu Pro Asn Asn Val Ser Lys Glu Asn Thr Ala Leu Asp 
            980                 985                 990         


Val Ile Glu Cys Gln Leu Gln Asn  Tyr Glu Lys Val Arg  Ala His Gln 
        995                 1000                 1005             


Leu Phe  Lys Glu Val Gln Lys  Leu Glu Gln Tyr Ile  Tyr His Lys 
    1010                 1015                 1020             


Val Glu  Asn Lys Glu Val Leu  Lys His Lys Gly Asn  Gln Asn Phe 
    1025                 1030                 1035             


Arg Asn  Tyr Leu Leu Tyr Gly  Leu Tyr Asp Arg Asp  Leu Ser Gln 
    1040                 1045                 1050             


Glu Phe  Val Val Ile Lys Ser  Glu Asn Phe Glu Asn  Ile Ser Ile 
    1055                 1060                 1065             


Lys Glu  Ile Lys Glu Lys Ala  Ala Lys Leu Glu Gln  Gln Leu Phe 
    1070                 1075                 1080             


Ile Leu  Thr Tyr Ile Arg Asn  Lys Phe Ala His Asn  Gln Met Pro 
    1085                 1090                 1095             


Asn Lys  Glu Phe Tyr Asp Phe  Cys Gln Glu Ile Val  Pro Cys Glu 
    1100                 1105                 1110             


Asn Thr  Asn Gln Phe Tyr Ala  Asp Tyr Tyr Leu Met  Val Phe Ser 
    1115                 1120                 1125             


Ser Ile  Val Asn Glu Leu Ser  Ile Asn 
    1130                 1135         


<210>  2670
<211>  1029
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2670

Met His Val Thr Thr Thr Asn Lys Pro Leu Leu Ala Ala Tyr Leu Asn 
1               5                   10                  15      


Met Ala Arg Asn Asn Cys Tyr Met Ala Leu Ser His Ile Ala Glu Leu 
            20                  25                  30          


Met Gly Lys Ser Ser Val Met Asn Glu Asp Ala Ile Gln Glu Cys Ala 
        35                  40                  45              


Val Ile Arg Ala Leu Ala Gly Asn Ile Lys Pro Asp Glu Ser Phe Arg 
    50                  55                  60                  


Ile Ile Asp Met Val Asp Gln His Phe Pro Phe Ile Arg Leu Leu Leu 
65                  70                  75                  80  


Lys Ser Arg Asn Asn Ser Ser Pro Thr Asp Tyr Ala Asn Cys Leu Thr 
                85                  90                  95      


Asp Phe Ile Lys Gln Leu Asn Glu Leu Arg Asn Phe His Thr His Gln 
            100                 105                 110         


Leu His Lys Pro Tyr Ile Thr Asp Ala Lys Val Val Ala Gln Leu Gln 
        115                 120                 125             


Phe Leu Phe Asp Ala Ser Arg Arg Glu Val Lys Lys Arg Phe Ser Leu 
    130                 135                 140                 


Glu Glu Gln Asp Val Lys His Leu Val Arg Lys Ser Ile Val Ile Ile 
145                 150                 155                 160 


Asp Asn Asn Lys Val Ala Val Glu Lys Glu Asn Tyr Val Tyr Ala Phe 
                165                 170                 175     


Ala Asn Lys Glu Gly Gln Phe Thr Asn Lys Gly Ile Ala Phe Leu Ile 
            180                 185                 190         


Ser Leu Phe Ile Glu Lys Lys Tyr Ala Tyr Leu Phe Leu Lys Gln Leu 
        195                 200                 205             


Ser Gly Phe Lys Asn Ser Asn Thr Lys Gln His Lys Ala Thr Leu Glu 
    210                 215                 220                 


Val Phe Cys Phe Tyr His Ile Arg Ile Pro Gln Pro Lys Leu Gln Ser 
225                 230                 235                 240 


Asn Asn Thr Lys Ile Gly Phe Leu Leu Asp Ala Leu Glu Glu Leu Lys 
                245                 250                 255     


Arg Cys Pro Ala Glu Leu Tyr Glu His Ile Ala Lys Asn Asp Lys Gln 
            260                 265                 270         


Arg Phe Lys Ser Ala Gly Ile Thr Glu Asp Thr Asn Asp Gln Pro Glu 
        275                 280                 285             


Ala Ile Leu Lys Arg Asn Gly Asp Arg Phe Ser Tyr Leu Ala Leu Arg 
    290                 295                 300                 


Tyr Leu Glu Leu Thr Asn Ser Leu Pro Gly Leu Gln Phe Tyr Phe Asp 
305                 310                 315                 320 


Leu Gly Lys Tyr Tyr Phe Lys Val Tyr Glu Lys Ser Ile Asp Ser Glu 
                325                 330                 335     


Leu Arg Leu Arg Arg Leu His Lys Asn Met Arg Asp Phe Gly Arg Thr 
            340                 345                 350         


Asn Asp Phe Asp Thr Val Lys Met Pro Gln Leu Trp Gln Gln Leu Ile 
        355                 360                 365             


Lys Arg Thr Asp Glu Leu Ser Glu Asn Tyr Ala Glu Pro Tyr Ile Val 
    370                 375                 380                 


Tyr Thr Ile Pro His Tyr His Ile Val Asn Asn Gln Ile Gly Ile Trp 
385                 390                 395                 400 


Leu Asn Lys Glu Arg Gln Met Pro Ser Leu Thr Pro Lys Ile Ser Asn 
                405                 410                 415     


Ala Glu Pro Gln Ile Trp Leu Ser Leu Tyr Glu Leu Pro Ala Leu Leu 
            420                 425                 430         


Phe Tyr His Leu Leu Thr Lys Gly Asn Lys Gly Gln Lys Asn Val Leu 
        435                 440                 445             


Gln Ile Leu Ser Lys His Arg Thr Ala Ile His Ser Phe Phe Lys Asp 
    450                 455                 460                 


Ile Glu Ser Ser Lys Leu Leu Pro Gly Phe Thr Ile Glu Thr Leu Asn 
465                 470                 475                 480 


Val Glu Leu Glu Lys Arg Asn Leu Lys His Asp Lys Ile Pro Lys Pro 
                485                 490                 495     


Leu Leu Gln Tyr Leu Leu Gln Gln Lys Pro Leu Lys Ser Ile Val Glu 
            500                 505                 510         


Ile Ala Gly Glu Arg Leu Ser Glu Leu Gln Asn Glu Thr Ile Phe Leu 
        515                 520                 525             


Leu Asp Lys Ile Asp Ile Asp Ile Glu Lys Ala Lys Glu Lys Ile Gly 
    530                 535                 540                 


Gly Lys His Tyr Arg Pro Ile Gln Thr Gly Lys Ile Ala Asp Phe Leu 
545                 550                 555                 560 


Ala Arg Asp Met Leu Phe Phe Gln Pro Ala Ile Asp Lys Ile Lys Gly 
                565                 570                 575     


Lys Ala Thr Ser Thr Leu Phe Gln Val Leu Gln Ala Arg Leu Ala Phe 
            580                 585                 590         


Tyr Gly Arg Asp Lys Glu Leu Leu Glu Gly Leu Tyr Lys Glu Cys Asn 
        595                 600                 605             


Leu Ile Gln Ser Lys Asn Pro His Pro Phe Leu Ser Gly Leu Pro Ile 
    610                 615                 620                 


Thr Asn Asn Leu Met Asp Tyr Tyr Arg Asn Tyr Leu Ile Lys Arg Asn 
625                 630                 635                 640 


Gln Tyr Leu Asp Lys Cys Leu Lys Lys Cys Lys Gln Gly Lys Ile Gly 
                645                 650                 655     


Ser Gln Asp Phe His Phe Leu His Leu Gly Glu Arg Glu Arg Lys Asn 
            660                 665                 670         


Gly Asn Thr Tyr Tyr Thr Asn Leu Ala Gly Lys Phe Ile Lys Met Pro 
        675                 680                 685             


Leu Asn Phe Pro Arg Gly Leu Phe Met Glu Glu Leu Ile Asn Tyr Phe 
    690                 695                 700                 


Glu Ser Ser Gly Asp Leu His Met Gln Asn Ile Ile Lys Asn Thr Pro 
705                 710                 715                 720 


Arg Leu Ser Thr Thr Phe Leu Leu Lys Glu Tyr Ile Asn Asn Val Leu 
                725                 730                 735     


Ser Asp Asp Thr Pro Asp Phe Tyr Asn Trp Lys Arg Ser Tyr Thr Val 
            740                 745                 750         


Phe Asn Arg Tyr Tyr Asp Lys Arg Lys Gln Asn Ser Arg Asp Ala Ile 
        755                 760                 765             


Thr Lys Ile Tyr Phe Asp Thr Ser Gln Leu Ser Glu Glu Ala Asn Lys 
    770                 775                 780                 


Ile Lys Ala Ala Ile Lys Lys Ile Glu Lys Ser Asp Ile Lys Gly Ala 
785                 790                 795                 800 


Glu Ser Ile Lys Arg Asn Tyr Lys Phe Tyr Gly Asp Asn Glu Lys Gln 
                805                 810                 815     


Leu Arg Gln Ala Lys Ala Cys Asp Thr Ile Leu Phe Leu Ala Ile Arg 
            820                 825                 830         


Asp Leu Phe Pro Thr Ile Glu Ser Ser Val Phe Lys Gly Leu Ala Ile 
        835                 840                 845             


Glu Gln Phe Arg Leu Ser Asp Ile Leu Pro Asp Ala Glu Lys Gly Ile 
    850                 855                 860                 


Leu Ser Gln Ser Ile Glu Ile Arg Leu Pro Leu Tyr Asn Lys Phe Ile 
865                 870                 875                 880 


Ile Gln Lys Gly Leu Lys Leu Lys Asn Tyr Gly Asp Phe Arg Arg Phe 
                885                 890                 895     


Leu Lys Asp Arg Arg Leu Glu Ser Leu Met Pro Tyr Phe Glu Glu Asp 
            900                 905                 910         


Asp Ile Asp Arg Ser Ser Leu Glu Lys Glu Leu Glu Asp Tyr Asp Thr 
        915                 920                 925             


Ala Arg Ile Glu Ile His Arg Val Val Leu Asp Phe Glu Ser His Val 
    930                 935                 940                 


Ile Thr Met Tyr Gln Leu Asn Tyr Leu Asn Pro Glu Asp Pro Cys Ile 
945                 950                 955                 960 


Asn His Glu Thr Ile Leu Asn Cys Phe Phe Gln Asn Asp Pro Ser Asp 
                965                 970                 975     


Ile Arg Lys Gln Leu Met Glu Asn Ile Arg Asn Arg Phe Ser His Asn 
            980                 985                 990         


Glu Tyr Pro Asp Phe Glu Lys Phe  Lys Glu Ile Ile Gln  Glu Asn His 
        995                 1000                 1005             


Gln Gln  Lys Thr Ile Ala Gly  Lys Phe Val Thr Leu  Ala Asn Gln 
    1010                 1015                 1020             


Tyr Phe  Ser Val Glu Glu 
    1025                 


<210>  2671
<211>  1000
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2671

Met Glu Ser Ile Ile Gly Leu Gly Leu Ser Phe Asn Pro Tyr Lys Thr 
1               5                   10                  15      


Ala Asp Lys His Tyr Phe Gly Ser Phe Leu Asn Leu Ala Asp Asn Asn 
            20                  25                  30          


Leu Lys Ala Val Phe Ala Glu Phe Lys Glu Arg Ile Ser Asp Lys Ser 
        35                  40                  45              


Lys Asp Glu Asp Ile Ser Asn Leu Ile Glu Lys His Phe Ile Asp Asn 
    50                  55                  60                  


Met Ser Ile Val Asp Tyr Glu Lys Asn Ile Ser Ile Leu Asn Gly Tyr 
65                  70                  75                  80  


Leu Pro Ile Ile Asp Phe Leu Asp Asp Glu Leu Glu Asn Asn Leu Asn 
                85                  90                  95      


Thr Arg Val Lys Asn Phe Lys Lys Ser Phe Ile Ile Leu Ala Glu Ala 
            100                 105                 110         


Leu Glu Thr Leu Arg Asn Tyr Tyr Thr His Phe Tyr His Asp Pro Ile 
        115                 120                 125             


Thr Phe Gly Asp Asn Lys Glu Pro Leu Leu Glu Leu Leu Asp Glu Val 
    130                 135                 140                 


Leu Leu Lys Thr Ile Leu Asp Val Lys Lys Lys Tyr Leu Lys Thr Asp 
145                 150                 155                 160 


Lys Thr Lys Glu Ile Leu Lys Asp Ser Leu Arg Glu Glu Met Asp Leu 
                165                 170                 175     


Leu Val Ile Arg Lys Thr Asp Glu Leu Arg Glu Lys Lys Lys Thr Asn 
            180                 185                 190         


Pro Lys Phe Lys Phe Ser Thr Asp Pro Thr Gln Ile Arg Asn Ser Ile 
        195                 200                 205             


Phe Asn Asp Ala Phe Gln Gly Leu Leu Tyr Glu Asp Lys Glu Asn Asn 
    210                 215                 220                 


Gly Lys Thr Gln Val Ser Tyr Arg Ala Lys Thr Lys Leu Asn Pro Lys 
225                 230                 235                 240 


Asp Ile His Lys Gln Glu Glu Arg Asp Phe Glu Ile Pro Leu Ser Thr 
                245                 250                 255     


Ser Gly Ile Val Phe Leu Met Ser Leu Phe Leu Ser Lys Lys Glu Ile 
            260                 265                 270         


Glu Asp Phe Lys Ser Asn Ile Lys Gly Phe Lys Gly Lys Val Val Lys 
        275                 280                 285             


Asp Glu Asn His Asn Ser Leu Lys Tyr Met Ala Thr His Arg Val Tyr 
    290                 295                 300                 


Ser Ile Leu Ala Phe Lys Gly Leu Lys Tyr Arg Ile Lys Thr Asp Thr 
305                 310                 315                 320 


Phe Ser Lys Val Thr Leu Met Met Gln Met Ile Asp Glu Leu Ser Lys 
                325                 330                 335     


Val Pro Asp Cys Val Tyr Gln Asn Leu Ser Glu Thr Lys Gln Lys Asp 
            340                 345                 350         


Phe Ile Glu Asp Trp Asn Glu Tyr Leu Lys Asp Asn Glu Glu Asn Thr 
        355                 360                 365             


Glu Asn Leu Val Asn Ser Arg Val Val His Pro Leu Ile Arg Lys Arg 
    370                 375                 380                 


Tyr Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe 
385                 390                 395                 400 


Ala Asn Phe Lys Thr Leu Lys Phe Gln Val Phe Met Gly Tyr Tyr Ile 
                405                 410                 415     


His Asp Gln Arg Thr Lys Thr Ile Gly Thr Thr Asn Ile Thr Thr Glu 
            420                 425                 430         


Arg Thr Val Lys Glu Lys Ile Asn Val Phe Gly Lys Leu Ser Lys Met 
        435                 440                 445             


Asp Asn Leu Lys Lys His Phe Phe Ser Gln Leu Ser Asp Glu Glu Asn 
    450                 455                 460                 


Thr Asp Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Phe Leu Thr Gln 
465                 470                 475                 480 


Ala Asp Asn Ser Pro Ala Asn Asn Ile Pro Ile Tyr Leu Glu Leu Lys 
                485                 490                 495     


Asn Gln Gln Ile Ile Lys Glu Lys Asp Asp Ile Lys Ala Glu Val Asn 
            500                 505                 510         


Asn Ser Gln Asn Arg Asn Pro Asn Lys Pro Ser Lys Arg Asp Leu Leu 
        515                 520                 525             


Asn Lys Ile Ser Asn Thr Asn Glu Asp Phe Tyr Gln Gly Asp Pro Thr 
    530                 535                 540                 


Ala Ile Leu Ser Leu Asn Glu Ile Pro Ala Leu Leu His Leu Phe Leu 
545                 550                 555                 560 


Val Gln Pro Asp Asn Lys Thr Gly Gln Gln Ile Glu Asn Ile Ile Arg 
                565                 570                 575     


Ile Lys Ile Glu Lys Gln Phe Asn Ser Ile Lys Asn Pro Ser Lys Asp 
            580                 585                 590         


Asp Lys Gly Val Pro Lys Ser Leu Phe Ala Asp Thr Asn Val Arg Val 
        595                 600                 605             


Asn Ala Ile Lys Leu Lys Lys Asp Leu Gly Glu Glu Leu Asp Met Leu 
    610                 615                 620                 


Asn Lys Lys Gln Ile Val Phe Lys Glu Asn Gln Lys Ala Ser Ser Asn 
625                 630                 635                 640 


Tyr Asp Glu Leu Leu Lys Lys His Gln Phe Thr Pro Lys Asn Lys Arg 
                645                 650                 655     


Pro Ala Leu Arg Lys Tyr Val Phe Tyr Asn Ser Glu Lys Gly Glu Glu 
            660                 665                 670         


Ala Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Lys Gly Phe 
        675                 680                 685             


Lys Thr Lys Trp Lys Gly Tyr Gln His Ser Glu Leu Gln Arg Lys Leu 
    690                 695                 700                 


Ala Phe Tyr Asp Arg His Thr Lys Gln Asp Ile Lys Glu Leu Leu Ser 
705                 710                 715                 720 


Gly Cys Glu Phe Asp His Phe Leu Leu Asp Ile Asn Ala Cys Phe Lys 
                725                 730                 735     


Glu Asp Asp Phe Glu Asp Phe Phe Ser Lys Tyr Leu Lys Asn Arg Ile 
            740                 745                 750         


Glu Thr Leu Asn Ile Ile Leu Lys Gln Leu His Asp Phe Lys Asn Glu 
        755                 760                 765             


Pro Thr Pro Leu Lys Gly Val Phe Lys Asn Cys Leu Lys Phe Leu Lys 
    770                 775                 780                 


Gln Lys Asn Tyr Val Thr Glu Asn Pro Glu Ile Ile Lys Lys Arg Ile 
785                 790                 795                 800 


Leu Ala Lys Pro Ala Phe Leu Pro Arg Gly Ile Phe Asp Glu Arg Pro 
                805                 810                 815     


Thr Met Lys Lys Gly Lys Asn Pro Leu Ile Asp Arg Asp Glu Phe Ala 
            820                 825                 830         


Lys Trp Phe Val Glu Tyr Leu Glu Asn Lys Asp Tyr Gln Lys Phe Tyr 
        835                 840                 845             


Asn Ser Glu Glu Tyr Arg Ile Arg Asp Ala Asp Phe Lys Lys Asn Ala 
    850                 855                 860                 


Val Ile Lys Lys Gln Lys Leu Lys Asp Phe Tyr Thr Leu Gln Met Val 
865                 870                 875                 880 


Asn Tyr Leu Leu Lys Glu Val Phe Gly Lys Asp Glu Met Asn Leu Gln 
                885                 890                 895     


Leu Ser Glu Leu Phe Gln Thr Arg Gln Glu Arg Leu Lys Leu Gln Gly 
            900                 905                 910         


Ile Ala Lys Lys Gln Met Asn Lys Glu Thr Gly Asp Ser Ser Glu Asn 
        915                 920                 925             


Thr Arg Asn Gln Thr Tyr Ile Trp Asn Lys Asp Val Pro Val Ser Phe 
    930                 935                 940                 


Phe Asn Gly Lys Val Thr Ile Asp Lys Val Lys Leu Lys Asn Ile Gly 
945                 950                 955                 960 


Lys Tyr Lys Arg Tyr Glu Arg Asp Glu Arg Val Lys Thr Phe Ile Gly 
                965                 970                 975     


Tyr Glu Val Asp Glu Lys Trp Met Met Tyr Leu Pro His Asn Trp Lys 
            980                 985                 990         


Tyr Ser Cys Val Tyr Pro Ser Lys  
        995                 1000 


<210>  2672
<211>  985
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2672

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Lys His Leu 
145                 150                 155                 160 


Arg Asn Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys Gly Tyr 
                165                 170                 175     


Ala Phe Phe Ile Ser Lys Phe Leu Glu Arg Lys Tyr Ser Tyr Leu Phe 
            180                 185                 190         


Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln Tyr Arg 
        195                 200                 205             


Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro Val Glu 
    210                 215                 220                 


Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu Asp Ile 
225                 230                 235                 240 


Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr Leu Glu 
                245                 250                 255     


Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr Asp Ala 
            260                 265                 270         


Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe Arg Ser 
        275                 280                 285             


Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala Asp Phe 
    290                 295                 300                 


Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His Asn Gly 
305                 310                 315                 320 


Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr Ile Asn 
                325                 330                 335     


Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser Ala Lys 
            340                 345                 350         


Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser Thr Asp 
        355                 360                 365             


Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln Ser Thr 
    370                 375                 380                 


Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val Leu Pro 
385                 390                 395                 400 


Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala Lys Met 
                405                 410                 415     


Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala Met Leu 
            420                 425                 430         


Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His Cys Pro 
        435                 440                 445             


Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser Thr Lys 
    450                 455                 460                 


Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg Val Met 
465                 470                 475                 480 


Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu Arg Ile 
                485                 490                 495     


Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile Leu Lys 
            500                 505                 510         


Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp Leu Gln 
        515                 520                 525             


Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn Phe Gln 
    530                 535                 540                 


Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn Asp Leu 
545                 550                 555                 560 


Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn Pro His 
                565                 570                 575     


Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile Glu Phe 
            580                 585                 590         


Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg Ile Gln 
        595                 600                 605             


Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro Leu Arg 
    610                 615                 620                 


Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu Ala Ile 
625                 630                 635                 640 


Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys Leu Lys 
                645                 650                 655     


Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu Lys Ser 
            660                 665                 670         


Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg Thr Tyr 
        675                 680                 685             


Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn Tyr Arg 
    690                 695                 700                 


Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser Tyr Leu 
705                 710                 715                 720 


Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro Ser Lys 
                725                 730                 735     


Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp Arg Leu 
            740                 745                 750         


Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile Ile Arg 
        755                 760                 765             


Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys Glu Tyr 
    770                 775                 780                 


Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu Glu Asn 
785                 790                 795                 800 


Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp Leu Asn 
                805                 810                 815     


Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr Gly Lys 
            820                 825                 830         


Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn Lys Val 
        835                 840                 845             


Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val Lys Ile 
    850                 855                 860                 


Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu Glu Ala 
865                 870                 875                 880 


Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala Met Val 
                885                 890                 895     


Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr Tyr Asp 
            900                 905                 910         


Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln Lys Ile 
        915                 920                 925             


Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His Asp Lys 
    930                 935                 940                 


Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Leu Val Tyr Ala 
945                 950                 955                 960 


Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile Lys Leu 
                965                 970                 975     


Glu Asp Leu Ser Asn Asp Ser Ser Ala 
            980                 985 


<210>  2673
<211>  1059
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2673

Met Ser Tyr Lys Lys Glu Pro Lys Glu Ile Tyr Arg Asn Ala Leu Ala 
1               5                   10                  15      


Val Tyr Leu Asn Met Ala Val Asp Asn Leu Pro Lys Trp Leu Asn Leu 
            20                  25                  30          


Glu Val Pro Lys Gly Gln Ser Ile Lys Lys Glu Leu Glu Asn Val Asp 
        35                  40                  45              


Asn Thr Glu Lys Met Arg Ser Ile Trp Gly Ala Ala Gln Lys Asn Ile 
    50                  55                  60                  


Tyr Phe Val Glu Trp Ala Val Asn Asn Lys Arg Tyr Phe Ala Pro Phe 
65                  70                  75                  80  


Pro Glu Glu Glu Asn Met Gln Asp Val Val Leu Lys Asp Asn Tyr Asp 
                85                  90                  95      


Lys Leu Val Gly Leu Val Asp Met Leu Val Asn Ile Arg Asn Tyr Trp 
            100                 105                 110         


Ser His Ile Lys His Ser Asn Ser Val Ile Glu Asn Glu Leu Lys Glu 
        115                 120                 125             


Ser Asn Glu Leu Lys Asp Phe Leu Leu Glu Leu Tyr Leu Arg Ala Cys 
    130                 135                 140                 


Gly Ser Thr Glu Val Glu Ile Pro Gln Met Tyr Lys Gly Ser Glu Gly 
145                 150                 155                 160 


Leu Tyr Val Cys Asp Lys Asp Pro Lys Ser Glu Pro Glu Pro Phe Lys 
                165                 170                 175     


Val Ile Cys Ile Thr Asn Glu Phe Ser Ile Thr Gly Tyr Val Phe Tyr 
            180                 185                 190         


Ala Cys Met Phe Leu Asp Gly Gln Gln Ile Asn Ser Phe Met Glu Ala 
        195                 200                 205             


Met Glu Gln Ser Asn Tyr Lys Phe Asp Glu Leu Glu Lys Arg Arg Met 
    210                 215                 220                 


Phe Arg Leu Thr Asn Pro Lys Glu Ala Tyr Pro Asp Glu Leu Thr Lys 
225                 230                 235                 240 


Lys Thr Lys Gly Phe Leu Tyr Ala Arg Asp Val Tyr Val Tyr Trp Arg 
                245                 250                 255     


Val Arg Gly His Arg Asp Asn Val Phe Glu Glu His Ser Leu Asp Asp 
            260                 265                 270         


Lys Glu Ala Tyr Tyr Ser Met Leu Glu Tyr Leu Lys Arg Cys Pro Lys 
        275                 280                 285             


Glu Arg Met Glu Leu Val Asn Gly Val Pro Asp Leu Met Lys Gln Tyr 
    290                 295                 300                 


Ser Val Gly Asp Thr Leu Tyr Asp Val Arg Glu Lys Asn Lys Phe Met 
305                 310                 315                 320 


Glu Cys Gly Leu Glu Phe Trp Asp Asn Glu Ile Glu Arg Leu Ser Thr 
                325                 330                 335     


Val Ser Thr Lys Ser Asn Pro Leu Ala Thr Trp Lys Trp Gly His His 
            340                 345                 350         


Gln Ser Ala Asp Tyr Lys His Lys Ile Lys Val Glu Leu Glu Lys Glu 
        355                 360                 365             


Ala Lys Glu His Gly Arg Pro Tyr Arg Phe Pro Arg Tyr Gln Lys Val 
    370                 375                 380                 


Val Phe Asp Leu Pro Thr Thr Asp Glu Glu Lys Leu Asn Tyr Arg Asn 
385                 390                 395                 400 


Asp Glu His Gly Phe Pro Tyr Tyr Leu Ile Lys Asp Asp Ser Asn Thr 
                405                 410                 415     


Phe Thr Lys Ala Met Phe Cys Tyr Glu Phe Met Asn Arg Glu Lys Val 
            420                 425                 430         


Ile Gly Leu Met Gly Ser Arg Leu Leu Cys Ser Ile Leu Glu Tyr Tyr 
        435                 440                 445             


Leu Trp Lys Tyr Pro Val Thr Asp Thr Ser His Ala Thr Glu Asn Asn 
    450                 455                 460                 


Arg Tyr Lys Phe Trp Val Glu Leu Phe Lys Ala Cys Tyr Ser Tyr Ile 
465                 470                 475                 480 


Lys Asp Phe Thr Val Pro Glu Lys Glu Lys Asn Leu Val Thr Leu Glu 
                485                 490                 495     


Lys Val Glu Lys Arg Ile Asn Leu Leu Thr Glu Arg Tyr Lys Ala Ile 
            500                 505                 510         


Thr Glu Asp Glu Lys Ile Arg Pro His Ser Lys Ile Leu Phe Ile Leu 
        515                 520                 525             


Asp Thr Trp Asn Gln Met Leu Thr Phe Gly Gln Pro Thr Asn Leu Ala 
    530                 535                 540                 


His Ala Asn Asp Ser Asp Lys Gly Val Ile Gly Gly Lys Asn Gly Tyr 
545                 550                 555                 560 


Gln Glu Leu Met Arg Cys Leu Ser Lys Met Asp Asp Leu Glu Glu Asn 
                565                 570                 575     


Arg Asn Phe Ala Tyr Leu Glu Leu Cys Lys Lys Leu Gln Ile Leu Gly 
            580                 585                 590         


Lys Asp Lys Thr Lys Thr Ser Tyr Phe Tyr Ile Ile Asn Ser Ser Phe 
        595                 600                 605             


Gln Lys Tyr Gly Val Thr Lys Ser Pro Thr Glu Leu Asn Lys Cys Gln 
    610                 615                 620                 


Thr Ile Asp Ser Ile Phe Asp Leu Cys Lys Lys Tyr Arg Glu Ala Met 
625                 630                 635                 640 


Leu Ala Lys Phe Arg Leu Leu Leu Ile Asp Phe Ser Val Asp Ser Leu 
                645                 650                 655     


Arg Pro Ala Tyr Glu Met Arg Trp Leu Gly Leu Ser Asp Ser Arg Thr 
            660                 665                 670         


His Glu Ala Ser Gln Gln Thr Lys Pro Thr Gly Asn Arg Thr Leu Glu 
        675                 680                 685             


Thr Asn Ile Ile Asn Val Asp Lys Lys Leu Tyr Ala Ala Val Gly Leu 
    690                 695                 700                 


Pro Arg Asp Ile Arg Gln Leu Pro Gly Leu Ser Lys Tyr Ile Asp Ala 
705                 710                 715                 720 


Glu Asn Leu Gln Asn Ile His Ala Lys Ile Tyr Pro Ser Pro Asn Asn 
                725                 730                 735     


Cys Thr Leu Leu Ile Pro Asp Phe Tyr Thr Lys Asp Gly Leu Glu Leu 
            740                 745                 750         


Ser Thr Leu Arg Gly Asp Gln Ser Ile Arg Lys Arg Leu Phe Leu Ile 
        755                 760                 765             


Arg Arg Gln Asp Thr Val Leu Ser His Ile Ala Tyr Gln Lys Gly Ile 
    770                 775                 780                 


Lys Ala Glu Gly Arg Met Thr Glu Asp Met Gln Leu Ile Asn Ser Asn 
785                 790                 795                 800 


Phe Gln Glu Ala Glu Met Thr Leu Pro Ile Asn Lys Glu Gly Glu Thr 
                805                 810                 815     


Ile Leu Ser Ile His Phe Tyr Tyr Arg Tyr Tyr Lys Gln Asn Arg Tyr 
            820                 825                 830         


Gln Leu Pro Lys Lys Leu Thr Thr Asp Leu Cys Glu Leu Leu Val Phe 
        835                 840                 845             


Arg Asn Ile Leu Gln Lys Gly Ala Val Ile Lys Phe Asn Arg Met Glu 
    850                 855                 860                 


Leu Val Thr Lys Glu Thr Leu Thr Pro Asp Glu Leu Met Asn His Leu 
865                 870                 875                 880 


Ser Lys Glu Glu Gln Met Leu Pro Glu Ile Glu Arg Gln Arg Ile Ile 
                885                 890                 895     


Glu Glu Arg Phe Ala Ala Met Lys Thr Asn Val Phe Lys Pro Ser Thr 
            900                 905                 910         


Asn Arg Ser Leu Phe Tyr Met Asp Glu Leu Leu Asn Ser Tyr Thr Ile 
        915                 920                 925             


Cys Arg Arg Ala Ile Ile Glu Lys Leu Phe Lys Leu Glu Gln Arg Val 
    930                 935                 940                 


Leu Ser Ile Ser Asn Met Lys Ile Asp Asp Thr Phe Val Ser Phe Arg 
945                 950                 955                 960 


Arg Ile Ser Asn Trp Leu Phe Glu Asp Arg Val Ile Asn Glu Ser Glu 
                965                 970                 975     


Met Ile Leu Leu Glu Glu Ile Arg Asn Thr Ala Met His Gly Lys Ile 
            980                 985                 990         


Pro Ser Pro Glu Tyr Leu Pro Ile  Asp Ile Val Asp Glu  Thr Lys Phe 
        995                 1000                 1005             


Lys Asp  Ile Thr Val Glu Lys  Lys Gln Tyr Leu Asn  Ile Phe Gly 
    1010                 1015                 1020             


Lys Gly  Met Glu Ile Thr Lys  Glu Ile Leu Asn Arg  Leu Asp Gln 
    1025                 1030                 1035             


Thr Tyr  Pro Gln Lys Gln Gln  Glu Thr Asn Gly Lys  Arg Tyr Ala 
    1040                 1045                 1050             


Lys Ser  Arg Phe Ser Arg 
    1055                 


<210>  2674
<211>  1112
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2674

Met Glu Asn Gln Glu Leu Lys Thr Arg Thr Met Lys Ser Glu Pro Tyr 
1               5                   10                  15      


Tyr Tyr Gly Ala Phe Leu Asn Met Ala Arg Leu Asn Ile Phe Asn Ile 
            20                  25                  30          


Ser Asn His Leu Ser Asn Lys Leu Asn Ile Leu Pro Thr Leu Ser Ser 
        35                  40                  45              


Glu Glu His Ile Ala Asn Ala Phe Phe Thr Asp Lys Asn Thr Lys Ile 
    50                  55                  60                  


Lys Trp Glu His Thr Tyr Asp Ile Leu Arg Arg Phe Ile Pro Ile Val 
65                  70                  75                  80  


Lys Val Phe Asp Thr Glu Ser Leu Pro Lys Gly Glu Val Gly Asn Asn 
                85                  90                  95      


Thr Gly Lys Asp Phe Ser Lys Met Ser Asp Thr Leu Lys Ile Ile Phe 
            100                 105                 110         


Lys Glu Leu Asn Glu Phe Arg Asn Asp Tyr Ser His Tyr Tyr Ser Thr 
        115                 120                 125             


Glu Lys Glu Asp Lys Arg Lys Ile Thr Ile Ser Asp Glu Leu Ala Asn 
    130                 135                 140                 


Phe Leu Asn Glu Asn Phe Lys Arg Ala Ile Ala Tyr Thr Lys Lys Arg 
145                 150                 155                 160 


Phe Lys Gly Val Phe Thr Glu Lys Asp Phe Glu Leu Ala Asn Asn Ile 
                165                 170                 175     


Gln Leu Phe Asn Lys Asp Lys Glu Ile Thr Glu Lys Gly Leu Ala Phe 
            180                 185                 190         


Leu Thr Ser Ile Phe Leu Glu Arg Glu Tyr Ala Phe Gln Phe Ile Ser 
        195                 200                 205             


Lys Ile Glu Gly Leu Lys Gly Thr Gln Lys Ser Glu Tyr Arg Ala Thr 
    210                 215                 220                 


Arg Glu Val Phe Met Ala Tyr Cys Val Asn Leu Pro His Asp Lys Phe 
225                 230                 235                 240 


Ile Ser Glu Asp Ala Lys Gln Ser Phe Ser Leu Asp Ile Ile Ser Glu 
                245                 250                 255     


Leu Asn Arg Cys Pro Gln Thr Leu Phe Asn Val Ile Thr Glu Lys Glu 
            260                 265                 270         


Gln Glu Lys Phe Arg Pro Thr Ile Asn Gln Gln Glu Lys Asn Asn Ile 
        275                 280                 285             


Ile Asn Asn Ser Val Pro Tyr Asp Ile Glu Asp Tyr Glu Glu Tyr Val 
    290                 295                 300                 


Asn Ser Ile Thr Lys Lys Ile Arg Tyr Asp Asn Arg Phe Pro Phe Phe 
305                 310                 315                 320 


Ala Leu Lys Phe Ile Asp Glu Thr Gln Val Phe Glu Lys Ile Arg Phe 
                325                 330                 335     


Gln Ile Asp Leu Gly Glu Ile Leu Leu Asp Glu Tyr Thr Lys Gln Leu 
            340                 345                 350         


Ala Asn Asn Glu Glu Lys Arg Gln Val Val Gln Asn Ala Lys Ala Phe 
        355                 360                 365             


Gly Arg Leu Asn Asp Phe Ile Asp Glu Asn Asn Val Leu Glu Asn Ile 
    370                 375                 380                 


Asn Lys Gln Asn Gly Ser Ala Ser Phe Ile Gln Tyr Ala Pro Asn Tyr 
385                 390                 395                 400 


Asn Phe Asp Asn Asn Lys Ile Gly Ile Asp Thr Thr Gly Lys Arg Ile 
                405                 410                 415     


Met Pro Ile Leu Thr Lys Gln Thr Asp Asn Asn Lys Lys Val Lys Asn 
            420                 425                 430         


Lys Leu Lys Gln Pro Leu Pro Lys Ala Phe Leu Ser Ile His Glu Leu 
        435                 440                 445             


Pro Lys Ile Ile Leu Leu Glu Tyr Leu Glu Lys Gly Lys Ala Glu Lys 
    450                 455                 460                 


Leu Ile Asn Asp Phe Leu Leu Ile Asn Glu Ser Gln Leu Leu Asn Tyr 
465                 470                 475                 480 


Lys Tyr Ile Glu Glu Ile Lys Asn Lys Leu Asn Asn Phe Asp Val Phe 
                485                 490                 495     


Gln Lys Arg Ser Gln Arg Lys Lys Leu Gln Thr Ala Tyr Asn Lys Thr 
            500                 505                 510         


Asn Ile Glu Glu Leu Gln Ser Arg Lys Glu Glu Leu Asn Lys Ile Leu 
        515                 520                 525             


Lys Glu Tyr Lys Leu Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Glu 
    530                 535                 540                 


Tyr Trp Leu Asn Ile Glu Asp Val Thr Pro Asn Glu Ala Ile Ser Asp 
545                 550                 555                 560 


Arg Ile Lys Leu Met Lys Arg Asp Cys Val Asp Arg Leu Arg Asp Ile 
                565                 570                 575     


Lys Lys Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala 
            580                 585                 590         


Lys Asp Ile Val Asp Met Ile Ile Ser Lys Asp Ile Lys Gln Lys Ile 
        595                 600                 605             


Ser Ser Phe Tyr Tyr Asp Lys Ile Gln Glu Cys Leu Ala Leu Tyr Asn 
    610                 615                 620                 


Val Ser Glu Lys Arg Asp Leu Phe Leu Thr Ile Cys Asn Glu Leu Arg 
625                 630                 635                 640 


Leu Leu Asp Ala Asp Lys Gly His Pro Phe Leu Lys Asn Ile Asn Leu 
                645                 650                 655     


Asn Arg Ile Asn Tyr Thr Ser Asp Phe Tyr Val Lys Tyr Leu Gln Glu 
            660                 665                 670         


Lys Gly His Lys Leu Ile Lys Glu Thr Asn Tyr Arg Thr Gly Lys Leu 
        675                 680                 685             


Val Glu Lys Asp Lys Ser Trp Met Phe Leu Asn Phe Tyr Tyr Leu Lys 
    690                 695                 700                 


Lys Asn Glu Thr Leu Asn Lys Met Met Thr Ile Val Gln Leu Pro Asp 
705                 710                 715                 720 


Asp Lys Ser Lys Leu Pro Phe Thr Ile Ala Gln Leu Asp Lys Pro Lys 
                725                 730                 735     


Asn Thr Phe Glu Glu Trp Ile Asn Asn Ile Thr Lys Gly Lys Thr Lys 
            740                 745                 750         


Thr Asp Lys Glu Lys Pro Ile Asp Leu Pro Thr Asn Ile Phe Asp Lys 
        755                 760                 765             


Glu Ile Glu Glu Ile Leu Lys Asn Lys Leu Ser Glu Glu Lys Ile Ala 
    770                 775                 780                 


Phe Thr Glu Asn Ala Asn Tyr Asn Gln Leu Phe Lys Leu Trp Trp Thr 
785                 790                 795                 800 


Asp Cys Arg Lys Asp Asn Val Gln Lys Phe Tyr Asp Ala Glu Arg Glu 
                805                 810                 815     


Tyr Val Ile Tyr Asp Glu His Val Lys Phe Ile Pro Asn Thr Lys Pro 
            820                 825                 830         


Lys Phe Glu Asn Tyr Tyr Asn Glu Ser Phe Pro Ile Val Leu Thr Arg 
        835                 840                 845             


Leu Lys Arg Asp Arg Glu Glu Ala Arg Lys Leu Asn Arg Lys Leu Pro 
    850                 855                 860                 


Pro Ile Glu Lys Ser Gln Val Glu Lys Val Phe Lys Gln Ala Ile Gly 
865                 870                 875                 880 


Ser Thr Glu Lys Glu Ile Arg Leu Leu Gln Glu Glu Asp Arg Ile Met 
                885                 890                 895     


Leu Leu Met Phe Glu Gln Leu Leu Glu Thr Asp Asn Asn Leu Asn Leu 
            900                 905                 910         


Lys Leu Asn Asn Ala Glu Ser Leu Leu Asn Glu Gln Ile Thr Ile Lys 
        915                 920                 925             


Glu Lys Ile Ser Leu Lys Leu Ser Phe Asn Glu Gln Glu Asp Lys Lys 
    930                 935                 940                 


Glu Ile Ile Lys Thr Ile Ile Asp Lys Arg Lys Arg Lys Asp Phe Ser 
945                 950                 955                 960 


Ile Leu Arg Lys Phe Lys Tyr Asp Lys Arg Leu Pro Glu Leu Cys Glu 
                965                 970                 975     


Tyr Phe Glu Thr Asp Asp Ile Ser His Ser Asp Leu Lys Lys Glu Leu 
            980                 985                 990         


Asp Glu Tyr Asn Lys Ala Lys Glu  Gln Ile Leu Ala Asn  Ala Phe Met 
        995                 1000                 1005             


Leu Glu  Lys Thr Ile Ile Glu  Lys Asp Lys Asp Gly  Ile Lys Ala 
    1010                 1015                 1020             


Leu Phe  Leu Asn Asp Asn Gly  Glu Lys Lys Tyr Gly  Asn Val Gln 
    1025                 1030                 1035             


His Lys  Pro Tyr Leu Thr Trp  Leu Lys Asn Lys Gly  Leu Ile Asn 
    1040                 1045                 1050             


Asp Asn  Glu Tyr Leu Phe Ile  Asn Met Val Arg Asn  Thr Phe Ser 
    1055                 1060                 1065             


His Asn  Gln Phe Pro Gln Lys  Arg Thr Ile Gln Ile  Phe Ile Asp 
    1070                 1075                 1080             


Lys Asn  Arg Gly Asn Pro Ile  Thr Phe Ala Glu Thr  Ile Lys Asn 
    1085                 1090                 1095             


Ala Tyr  Asn Lys Lys Ile Glu  Glu Ile Ile Val Lys  Ile Lys 
    1100                 1105                 1110         


<210>  2675
<211>  1131
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2675

Met Glu Lys Thr Ile Glu Asn Gln Thr Gln Ser Lys Arg Thr Leu Asn 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Asp Glu Glu Lys Ile Thr Thr Ser Phe Leu Val Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Arg Gln Ser Leu Val Tyr Ser Asn Leu Thr 
65                  70                  75                  80  


Arg Tyr Met His Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Asp 
                85                  90                  95      


Asp Glu Arg Asp Lys Ala Glu Asn Tyr Gly Lys Asp Phe Gly Asn Leu 
            100                 105                 110         


Thr Asp Thr Leu Lys Glu Ile Phe Lys Glu Leu Asn Glu Phe Arg Asn 
        115                 120                 125             


Asp Tyr Ser His Tyr Tyr Ser Thr Glu Lys Lys Asp Lys Arg Lys Thr 
    130                 135                 140                 


Ile Val Ser Asp Lys Leu Lys Asn Phe Leu Asn Ile Asn Tyr Thr Arg 
145                 150                 155                 160 


Ala Ile Lys Tyr Thr Lys Ser Arg Phe Ile Asn Val Phe Ser Asp Asn 
                165                 170                 175     


Asn Phe Cys Leu Ala Glu Glu Ala Lys His Val Glu Asn Asp Asn Thr 
            180                 185                 190         


Ile Thr Gln Asp Gly Ile Val Phe Phe Thr Ser Met Phe Leu Asp Arg 
        195                 200                 205             


Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile Ile Gly Leu Lys Gly Thr 
    210                 215                 220                 


Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Thr Leu Met Ala Phe Cys 
225                 230                 235                 240 


Val Asn Leu Pro His Asp Lys Phe Val Ser Glu Asn Ser Glu Gln Gln 
                245                 250                 255     


Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu 
            260                 265                 270         


Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln His Phe Leu Pro Lys Leu 
        275                 280                 285             


Asp Asp Glu Gln Ile Asp Asn Val Leu Glu Asn Ser Val Pro Tyr Thr 
    290                 295                 300                 


Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn Ile Thr Lys Lys Val Arg 
305                 310                 315                 320 


Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu Lys Phe Ile Asp Gln Lys 
                325                 330                 335     


Lys Leu Phe Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val 
            340                 345                 350         


Leu Asp Glu Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Lys Arg Thr 
        355                 360                 365             


Val Thr Glu Asn Thr Lys Ala Phe Gly Met Leu Gln Asp Leu Asn Asp 
    370                 375                 380                 


Glu Glu Asn Val Leu Asn Lys Ile Asn Thr Gly Glu Ser Lys Ala Lys 
385                 390                 395                 400 


Phe Asp Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Thr Lys Asn 
            420                 425                 430         


Thr Asp Asn Lys Ile Lys Ser Asn Leu Leu Gln Pro Leu Pro Glu Ala 
        435                 440                 445             


Phe Leu Ser Ile Asn Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
    450                 455                 460                 


Glu Gln Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn 
465                 470                 475                 480 


Asn Ser Lys Ile Leu Asn Lys Glu Phe Ile Lys Ala Ile Lys Leu Lys 
                485                 490                 495     


Leu Asn Asp Leu Asp Val Phe Tyr Lys Arg Ser Gln Gly Arg Lys Gln 
            500                 505                 510         


Lys His Ala Tyr Leu Thr Lys Asp Lys Lys Tyr Asp Asn Glu Lys Ile 
        515                 520                 525             


Asn Glu Leu Lys Asn Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu 
    530                 535                 540                 


Tyr Asn Leu Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp 
545                 550                 555                 560 


Leu Asn Ile Ala Asp Val Gln Ala Lys Asn Ala Ile Ser Asp Arg Ile 
                565                 570                 575     


Lys Leu Met Lys Arg Asp Cys Ile Asn Arg Leu Lys Ser Met Lys Lys 
            580                 585                 590         


Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp 
        595                 600                 605             


Ile Val Asp Met Ile Ile Asp Glu Glu Lys Lys Lys Lys Ile Thr Ser 
    610                 615                 620                 


Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Lys 
625                 630                 635                 640 


Glu Lys Lys Glu Leu Phe Ile Leu Ile Cys Asn Asn Glu Leu Lys Leu 
                645                 650                 655     


Asn Asp Asp Asp Gly His Pro Phe Phe Lys Asn Ile Asn Phe Ser Asn 
            660                 665                 670         


Tyr Lys Tyr Thr Ser Glu Ile Tyr Gln Lys Tyr Leu Glu Glu Lys Gly 
        675                 680                 685             


His Lys Met Val Lys Glu Tyr Asn Pro Arg Lys Glu Asn Tyr Val Glu 
    690                 695                 700                 


Lys Asp Lys Ser Trp Leu Glu Ile Asn Phe Tyr Lys Lys Glu Trp Asn 
705                 710                 715                 720 


Glu Asn Ala Lys Lys Asp Leu Thr Val Val Lys Leu Pro Asp Asp Lys 
                725                 730                 735     


Ser Lys Ile Pro Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser 
            740                 745                 750         


Phe Glu Asn Trp Phe Lys Tyr Val Thr Asn Gly Lys Glu Thr Thr Asp 
        755                 760                 765             


Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp Glu Thr Leu 
    770                 775                 780                 


Lys Glu Leu Leu Lys Lys Glu Leu Ser Lys Asn Asn Ile Glu Phe Lys 
785                 790                 795                 800 


Glu Glu Asp Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Asp Lys Cys 
                805                 810                 815     


Arg Asn Asp Lys Thr Gln Lys Phe Tyr Ser Ala Glu Arg Glu Tyr Thr 
            820                 825                 830         


Phe Glu Glu Glu Lys Leu Asn Phe His Ile Asn Thr Lys Ser Lys Phe 
        835                 840                 845             


Glu Glu Tyr Ile Asn Pro Glu Phe Ala Glu Lys Val Phe Arg Leu Lys 
    850                 855                 860                 


Asn Gln Asn Arg Glu Lys Asp Asn Ile Ser Gly Arg Arg Leu Pro Pro 
865                 870                 875                 880 


Leu Lys Met Lys Glu Val Thr Lys Asn Met Val Lys Arg Ile Gly Asn 
                885                 890                 895     


Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Leu Met Leu 
            900                 905                 910         


Leu Met Phe Glu Lys Leu Val Asp Asn Asn Leu Lys Leu Lys Leu Glu 
        915                 920                 925             


Asn Val Asp Lys Leu Leu Asn Glu Ser Ile Glu Ile Asn Gln Ser Ile 
    930                 935                 940                 


Ser Gly Lys Leu Ser Phe Asp Asp Ser Gly Asp Asn Glu Asn Lys Lys 
945                 950                 955                 960 


Asp Arg Ala Ile Ile Cys Arg Asn Ile Thr Glu Thr Arg Lys Arg Lys 
                965                 970                 975     


Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Glu Glu Glu  Asn Ile Pro Ile Glu  Lys Ile Lys 
        995                 1000                 1005             


Ile Glu  Leu Asp Thr Tyr Ser  Lys Ala Lys Asp Val  Val Phe Asp 
    1010                 1015                 1020             


Leu Ile  Phe Asp Leu Glu Arg  Ala Ile Ile Asn Lys  Asp Glu Asn 
    1025                 1030                 1035             


Arg Ile  Lys Glu Leu Asn Lys  Asp Lys Asn Gly Val  Ile Gln Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Phe Trp Leu  Leu Glu Lys 
    1055                 1060                 1065             


Asn Leu  Ile Thr Glu Gln Glu  Phe Thr Phe Met Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Thr  Phe Ser His Asn Gln  Phe Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Leu Phe  Ile Lys Asn Trp Asn  Glu Asn Glu Phe Ala  Lys Gln Ile 
    1100                 1105                 1110             


Leu Asn  Val Tyr Asn Gln Lys  Asn Asn Asn Leu Ile  Lys Ser Ile 
    1115                 1120                 1125             


Lys Asp  Ile 
    1130     


<210>  2676
<211>  1131
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2676

Met Glu Lys Thr Ile Glu Asn Gln Thr Gln Ser Lys Arg Thr Leu Asn 
1               5                   10                  15      


Asn Thr Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Asp Glu Glu Lys Ile Thr Thr Ser Phe Leu Val Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Arg Gln Ser Leu Val Tyr Ser Asn Leu Thr 
65                  70                  75                  80  


Arg Tyr Met His Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Asp 
                85                  90                  95      


Asp Glu Arg Asp Lys Ala Glu Asn Tyr Gly Lys Asp Phe Gly Asn Leu 
            100                 105                 110         


Thr Asp Thr Leu Lys Glu Ile Phe Lys Glu Leu Asn Glu Phe Arg Asn 
        115                 120                 125             


Asp Tyr Ser His Tyr Tyr Ser Thr Glu Lys Lys Asp Lys Arg Lys Thr 
    130                 135                 140                 


Ile Val Ser Asp Lys Leu Lys Asn Phe Leu Asn Ile Asn Tyr Thr Arg 
145                 150                 155                 160 


Ala Ile Lys Tyr Thr Lys Ser Arg Phe Ile Asn Val Phe Ser Asp Asn 
                165                 170                 175     


Asn Phe Cys Leu Ala Glu Glu Ala Lys His Val Glu Asn Asp Asn Thr 
            180                 185                 190         


Ile Thr Gln Asp Gly Ile Val Phe Phe Thr Ser Met Phe Leu Asp Arg 
        195                 200                 205             


Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile Ile Gly Leu Lys Gly Thr 
    210                 215                 220                 


Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Thr Leu Met Ala Phe Cys 
225                 230                 235                 240 


Val Asn Leu Pro His Asp Lys Phe Val Ser Glu Asn Ser Glu Gln Gln 
                245                 250                 255     


Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu 
            260                 265                 270         


Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln His Phe Leu Pro Lys Leu 
        275                 280                 285             


Asp Asp Glu Gln Ile Asp Asn Val Leu Glu Asn Ser Val Pro Tyr Thr 
    290                 295                 300                 


Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn Ile Thr Lys Lys Val Arg 
305                 310                 315                 320 


Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu Lys Phe Ile Asp Gln Lys 
                325                 330                 335     


Lys Leu Phe Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val 
            340                 345                 350         


Leu Asp Glu Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Lys Arg Thr 
        355                 360                 365             


Val Thr Glu Asn Thr Lys Ala Phe Gly Met Leu Gln Asp Leu Asn Asp 
    370                 375                 380                 


Glu Glu Asn Val Leu Asn Lys Ile Asn Thr Gly Glu Ser Lys Ala Lys 
385                 390                 395                 400 


Phe Asp Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Thr Lys Asn 
            420                 425                 430         


Thr Asp Asn Lys Ile Lys Ser Asn Leu Leu Gln Pro Leu Pro Glu Ala 
        435                 440                 445             


Phe Leu Ser Ile Asn Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
    450                 455                 460                 


Glu Gln Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn 
465                 470                 475                 480 


Asn Ser Lys Ile Leu Asn Lys Glu Phe Ile Lys Ala Ile Lys Leu Lys 
                485                 490                 495     


Leu Asn Asp Leu Asp Val Phe Tyr Lys Arg Ser Gln Gly Arg Lys Gln 
            500                 505                 510         


Lys His Ala Tyr Leu Thr Lys Asp Lys Lys Tyr Asp Asn Glu Lys Ile 
        515                 520                 525             


Asn Glu Leu Lys Asn Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu 
    530                 535                 540                 


Tyr Asn Leu Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp 
545                 550                 555                 560 


Leu Asn Ile Ala Asp Val Gln Ala Lys Asn Ala Ile Ser Asp Arg Ile 
                565                 570                 575     


Lys Leu Met Lys Arg Asp Cys Ile Asn Arg Leu Lys Ser Met Lys Lys 
            580                 585                 590         


Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp 
        595                 600                 605             


Ile Val Asp Met Ile Ile Asp Glu Glu Lys Lys Lys Lys Ile Thr Ser 
    610                 615                 620                 


Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Lys 
625                 630                 635                 640 


Glu Lys Lys Glu Leu Phe Ile Leu Ile Cys Asn Asn Glu Leu Lys Leu 
                645                 650                 655     


Asn Asp Asp Asp Gly His Pro Phe Phe Lys Asn Ile Asn Phe Ser Asn 
            660                 665                 670         


Tyr Lys Tyr Thr Ser Glu Ile Tyr Gln Lys Tyr Leu Glu Glu Lys Gly 
        675                 680                 685             


His Lys Met Val Lys Glu Tyr Asn Pro Arg Lys Glu Asn Tyr Val Glu 
    690                 695                 700                 


Lys Asp Lys Ser Trp Leu Glu Ile Asn Phe Tyr Lys Lys Glu Trp Asn 
705                 710                 715                 720 


Glu Asn Ala Lys Lys Asp Leu Thr Val Val Lys Leu Pro Asp Asp Lys 
                725                 730                 735     


Ser Lys Ile Pro Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser 
            740                 745                 750         


Phe Glu Asn Trp Phe Lys Tyr Val Thr Asn Gly Lys Glu Thr Thr Asp 
        755                 760                 765             


Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp Glu Thr Leu 
    770                 775                 780                 


Lys Glu Leu Leu Lys Lys Glu Leu Ser Lys Asn Asn Ile Glu Phe Lys 
785                 790                 795                 800 


Glu Glu Asp Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Asp Lys Cys 
                805                 810                 815     


Arg Asn Asp Lys Thr Gln Lys Phe Tyr Ser Ala Glu Arg Glu Tyr Thr 
            820                 825                 830         


Phe Glu Glu Glu Lys Leu Asn Phe His Ile Asn Thr Lys Ser Lys Phe 
        835                 840                 845             


Glu Glu Tyr Ile Asn Pro Glu Phe Ala Glu Lys Val Phe Arg Leu Lys 
    850                 855                 860                 


Asn Gln Asn Arg Glu Lys Asp Asn Ile Ser Gly Arg Arg Leu Pro Pro 
865                 870                 875                 880 


Leu Lys Met Lys Glu Val Thr Lys Asn Met Val Lys Arg Ile Gly Asn 
                885                 890                 895     


Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Leu Met Leu 
            900                 905                 910         


Leu Met Phe Glu Lys Leu Val Asp Asn Asn Leu Lys Leu Lys Leu Glu 
        915                 920                 925             


Asn Val Asp Lys Leu Leu Asn Glu Ser Ile Glu Ile Asn Gln Ser Ile 
    930                 935                 940                 


Ser Gly Lys Leu Ser Phe Asp Asp Ser Gly Asp Asn Glu Asn Lys Lys 
945                 950                 955                 960 


Asp Arg Ala Ile Ile Cys Arg Asn Ile Thr Glu Thr Arg Lys Arg Lys 
                965                 970                 975     


Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Glu Glu Glu  Asn Ile Pro Ile Glu  Lys Ile Lys 
        995                 1000                 1005             


Ile Glu  Leu Asp Thr Tyr Ser  Lys Ala Lys Asp Val  Val Phe Asp 
    1010                 1015                 1020             


Leu Ile  Phe Asp Leu Glu Arg  Ala Ile Ile Asn Lys  Asp Glu Asn 
    1025                 1030                 1035             


Arg Ile  Lys Glu Leu Asn Lys  Asp Lys Asn Gly Val  Ile Gln Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Phe Trp Leu  Leu Glu Lys 
    1055                 1060                 1065             


Asn Leu  Ile Thr Glu Gln Glu  Phe Thr Phe Met Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Thr  Phe Ser His Asn Gln  Phe Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Leu Phe  Ile Lys Asn Trp Asn  Glu Asn Glu Phe Ala  Lys Gln Ile 
    1100                 1105                 1110             


Leu Asn  Val Tyr Asn Gln Lys  Asn Asn Asn Leu Ile  Lys Ser Ile 
    1115                 1120                 1125             


Lys Asp  Ile 
    1130     


<210>  2677
<211>  1131
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2677

Met Glu Lys Thr Ile Glu Asn Gln Thr Gln Ser Lys Arg Thr Leu Asn 
1               5                   10                  15      


Asn Thr Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Asp Glu Glu Lys Ile Thr Thr Ser Phe Leu Val Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Arg Gln Ser Leu Val Tyr Ser Asn Leu Thr 
65                  70                  75                  80  


Arg Tyr Met His Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Asp 
                85                  90                  95      


Asp Glu Arg Asp Lys Ala Glu Asn Tyr Gly Lys Asp Phe Gly Asn Leu 
            100                 105                 110         


Thr Asp Thr Leu Lys Glu Ile Phe Lys Glu Leu Asn Glu Phe Arg Asn 
        115                 120                 125             


Asp Tyr Ser His Tyr Tyr Ser Thr Glu Lys Lys Asp Lys Arg Lys Thr 
    130                 135                 140                 


Ile Val Ser Asp Lys Leu Lys Asn Phe Leu Asn Ile Asn Tyr Thr Arg 
145                 150                 155                 160 


Ala Ile Lys Tyr Thr Lys Ser Arg Phe Ile Asn Val Phe Ser Asp Asn 
                165                 170                 175     


Asn Phe Cys Leu Ala Glu Glu Ala Lys His Val Glu Asn Asp Asn Thr 
            180                 185                 190         


Ile Thr Gln Asp Gly Ile Val Phe Phe Thr Ser Met Phe Leu Asp Arg 
        195                 200                 205             


Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile Ile Gly Leu Lys Gly Thr 
    210                 215                 220                 


Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Thr Leu Met Ala Phe Cys 
225                 230                 235                 240 


Val Asn Leu Pro His Asp Lys Phe Val Ser Glu Asn Ser Glu Gln Gln 
                245                 250                 255     


Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu 
            260                 265                 270         


Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln His Phe Leu Pro Lys Leu 
        275                 280                 285             


Asp Asp Glu Gln Ile Asp Asn Val Leu Glu Asn Ser Val Pro Tyr Thr 
    290                 295                 300                 


Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn Ile Thr Lys Lys Val Arg 
305                 310                 315                 320 


Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu Lys Phe Ile Asp Gln Lys 
                325                 330                 335     


Lys Leu Phe Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val 
            340                 345                 350         


Leu Asp Glu Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Lys Arg Thr 
        355                 360                 365             


Val Thr Glu Asn Thr Lys Ala Phe Gly Met Leu Gln Asp Leu Asn Asp 
    370                 375                 380                 


Glu Glu Asn Val Leu Asn Lys Ile Asn Thr Gly Glu Ser Lys Ala Lys 
385                 390                 395                 400 


Phe Asp Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Thr Lys Asn 
            420                 425                 430         


Thr Asp Asn Lys Ile Lys Ser Asn Leu Leu Gln Pro Leu Pro Glu Ala 
        435                 440                 445             


Phe Leu Ser Ile Asn Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
    450                 455                 460                 


Glu Gln Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn 
465                 470                 475                 480 


Asn Ser Lys Ile Leu Asn Lys Glu Phe Ile Lys Ala Ile Lys Leu Lys 
                485                 490                 495     


Leu Asn Asp Leu Asp Val Phe Tyr Lys Arg Ser Gln Gly Arg Lys Gln 
            500                 505                 510         


Lys His Ala Tyr Leu Thr Lys Asp Lys Lys Tyr Asp Asn Glu Lys Ile 
        515                 520                 525             


Asn Glu Leu Lys Asn Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu 
    530                 535                 540                 


Tyr Asn Leu Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp 
545                 550                 555                 560 


Leu Asn Ile Ala Asp Val Gln Ala Lys Asn Ala Ile Ser Asp Arg Ile 
                565                 570                 575     


Lys Leu Met Lys Arg Asp Cys Ile Asn Arg Leu Lys Ser Met Lys Lys 
            580                 585                 590         


Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp 
        595                 600                 605             


Ile Val Asp Met Ile Ile Asp Glu Glu Lys Lys Lys Lys Ile Thr Ser 
    610                 615                 620                 


Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Lys 
625                 630                 635                 640 


Glu Lys Lys Glu Leu Phe Ile Leu Ile Cys Asn Asn Glu Leu Lys Leu 
                645                 650                 655     


Asn Asp Asp Asp Gly His Pro Phe Phe Lys Asn Ile Asn Phe Ser Asn 
            660                 665                 670         


Tyr Lys Tyr Thr Ser Glu Ile Tyr Gln Lys Tyr Leu Glu Glu Lys Gly 
        675                 680                 685             


His Lys Met Val Lys Glu Tyr Asn Pro Arg Lys Glu Asn Tyr Val Glu 
    690                 695                 700                 


Lys Asp Lys Ser Trp Leu Glu Ile Asn Phe Tyr Lys Lys Glu Trp Asn 
705                 710                 715                 720 


Glu Asn Ala Lys Lys Asp Leu Thr Val Val Lys Leu Pro Asp Asp Lys 
                725                 730                 735     


Ser Lys Ile Pro Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser 
            740                 745                 750         


Phe Glu Asn Trp Phe Lys Tyr Val Thr Asn Gly Lys Glu Thr Thr Asp 
        755                 760                 765             


Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp Glu Thr Leu 
    770                 775                 780                 


Lys Glu Leu Leu Lys Lys Glu Leu Ser Lys Asn Asn Ile Glu Phe Lys 
785                 790                 795                 800 


Glu Glu Asp Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Asp Lys Cys 
                805                 810                 815     


Arg Asn Asp Lys Thr Gln Lys Phe Tyr Ser Ala Glu Arg Glu Tyr Thr 
            820                 825                 830         


Phe Glu Glu Glu Lys Leu Asn Phe His Ile Asn Thr Lys Ser Lys Phe 
        835                 840                 845             


Glu Glu Tyr Ile Asn Pro Glu Phe Ala Glu Lys Val Phe Arg Leu Lys 
    850                 855                 860                 


Asn Gln Asn Arg Glu Lys Asp Asn Ile Ser Gly Arg Arg Leu Pro Pro 
865                 870                 875                 880 


Leu Lys Met Lys Glu Val Thr Lys Asn Met Val Lys Arg Ile Gly Asn 
                885                 890                 895     


Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Leu Met Leu 
            900                 905                 910         


Leu Met Phe Glu Lys Leu Val Asp Asn Asn Leu Lys Leu Lys Leu Glu 
        915                 920                 925             


Asn Val Asp Lys Leu Leu Asn Glu Ser Ile Glu Ile Asn Gln Ser Ile 
    930                 935                 940                 


Ser Gly Lys Leu Ser Phe Asp Asp Ser Gly Asp Asn Glu Asn Lys Lys 
945                 950                 955                 960 


Asp Arg Ala Ile Ile Cys Arg Asn Ile Thr Glu Thr Arg Lys Arg Lys 
                965                 970                 975     


Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Glu Glu Glu  Asn Ile Pro Ile Glu  Lys Ile Lys 
        995                 1000                 1005             


Ile Glu  Leu Asp Thr Tyr Ser  Lys Ala Lys Asp Val  Val Phe Asp 
    1010                 1015                 1020             


Leu Ile  Phe Asp Leu Glu Arg  Ala Ile Ile Asn Lys  Asp Glu Asn 
    1025                 1030                 1035             


Arg Ile  Lys Glu Leu Asn Lys  Asp Lys Asn Gly Val  Ile Gln Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Phe Trp Leu  Leu Glu Lys 
    1055                 1060                 1065             


Asn Leu  Ile Thr Glu Gln Glu  Phe Thr Phe Met Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Thr  Phe Ser His Asn Gln  Phe Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Leu Phe  Ile Lys Asn Trp Asn  Glu Asn Glu Phe Ala  Lys Gln Ile 
    1100                 1105                 1110             


Leu Asn  Val Tyr Asn Gln Lys  Asn Asn Asn Leu Ile  Lys Ser Ile 
    1115                 1120                 1125             


Lys Asp  Ile 
    1130     


<210>  2678
<211>  1131
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2678

Met Glu Lys Thr Ile Glu Asn Gln Thr Gln Ser Lys Arg Thr Leu Asn 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Asp Glu Glu Lys Ile Thr Thr Ser Phe Leu Val Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Arg Gln Ser Leu Val Tyr Ser Asn Leu Thr 
65                  70                  75                  80  


Arg Tyr Met His Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Asp 
                85                  90                  95      


Asp Glu Arg Asp Lys Ala Glu Asn Tyr Gly Lys Asp Phe Gly Asn Leu 
            100                 105                 110         


Thr Asp Thr Leu Lys Glu Ile Phe Lys Glu Leu Asn Glu Phe Arg Asn 
        115                 120                 125             


Asp Tyr Ser His Tyr Tyr Ser Thr Glu Lys Lys Asp Lys Arg Lys Thr 
    130                 135                 140                 


Ile Val Ser Asp Lys Leu Lys Asn Phe Leu Asn Ile Asn Tyr Thr Arg 
145                 150                 155                 160 


Ala Ile Lys Tyr Thr Lys Ser Arg Phe Ile Asn Val Phe Ser Asp Asn 
                165                 170                 175     


Asn Phe Cys Leu Ala Glu Glu Ala Lys His Val Glu Asn Asp Asn Thr 
            180                 185                 190         


Ile Thr Gln Asp Gly Ile Val Phe Phe Thr Ser Met Phe Leu Asp Arg 
        195                 200                 205             


Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile Ile Gly Leu Lys Gly Thr 
    210                 215                 220                 


Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Thr Leu Met Ala Phe Cys 
225                 230                 235                 240 


Val Asn Leu Pro His Asp Lys Phe Val Ser Glu Asn Ser Glu Gln Gln 
                245                 250                 255     


Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu 
            260                 265                 270         


Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln His Phe Leu Pro Lys Leu 
        275                 280                 285             


Asp Asp Glu Gln Ile Asp Asn Val Leu Glu Asn Ser Val Pro Tyr Thr 
    290                 295                 300                 


Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn Ile Thr Lys Lys Val Arg 
305                 310                 315                 320 


Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu Lys Phe Ile Asp Gln Lys 
                325                 330                 335     


Lys Leu Phe Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val 
            340                 345                 350         


Leu Asp Glu Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Lys Arg Thr 
        355                 360                 365             


Val Thr Glu Asn Thr Lys Ala Phe Gly Met Leu Gln Asp Leu Asn Asp 
    370                 375                 380                 


Glu Glu Asn Val Leu Asn Lys Ile Asn Thr Gly Glu Ser Lys Ala Lys 
385                 390                 395                 400 


Phe Asp Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Thr Lys Asn 
            420                 425                 430         


Thr Asp Asn Lys Ile Lys Ser Asn Leu Leu Gln Pro Leu Pro Glu Ala 
        435                 440                 445             


Phe Leu Ser Ile Asn Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
    450                 455                 460                 


Glu Gln Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn 
465                 470                 475                 480 


Asn Ser Lys Ile Leu Asn Lys Glu Phe Ile Lys Ala Ile Lys Leu Lys 
                485                 490                 495     


Leu Asn Asp Leu Asp Val Phe Tyr Lys Arg Ser Gln Gly Arg Lys Gln 
            500                 505                 510         


Lys His Ala Tyr Leu Thr Lys Asp Lys Lys Tyr Asp Asn Glu Lys Ile 
        515                 520                 525             


Asn Glu Leu Lys Asn Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu 
    530                 535                 540                 


Tyr Asn Leu Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp 
545                 550                 555                 560 


Leu Asn Ile Ala Asp Val Gln Ala Lys Asn Ala Ile Ser Asp Arg Ile 
                565                 570                 575     


Lys Leu Met Lys Arg Asp Cys Ile Asn Arg Leu Lys Ser Met Lys Lys 
            580                 585                 590         


Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp 
        595                 600                 605             


Ile Val Asp Met Ile Ile Asp Glu Glu Lys Lys Lys Lys Ile Thr Ser 
    610                 615                 620                 


Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Lys 
625                 630                 635                 640 


Glu Lys Lys Glu Leu Phe Ile Leu Ile Cys Asn Asn Glu Leu Lys Leu 
                645                 650                 655     


Asn Asp Asp Asp Gly His Pro Phe Phe Lys Asn Ile Asn Phe Ser Asn 
            660                 665                 670         


Tyr Lys Tyr Thr Ser Glu Ile Tyr Gln Lys Tyr Leu Glu Glu Lys Gly 
        675                 680                 685             


His Lys Met Val Lys Glu Tyr Asn Pro Arg Lys Glu Asn Tyr Val Glu 
    690                 695                 700                 


Lys Asp Lys Ser Trp Leu Glu Ile Asn Phe Tyr Lys Lys Glu Trp Asn 
705                 710                 715                 720 


Glu Asn Ala Lys Lys Asp Leu Thr Val Val Lys Leu Pro Asp Asp Lys 
                725                 730                 735     


Ser Lys Ile Pro Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser 
            740                 745                 750         


Phe Glu Asn Trp Phe Lys Tyr Val Thr Asn Gly Lys Glu Thr Thr Asp 
        755                 760                 765             


Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp Glu Thr Leu 
    770                 775                 780                 


Lys Glu Leu Leu Lys Lys Glu Leu Ser Lys Asn Asn Ile Glu Phe Lys 
785                 790                 795                 800 


Glu Glu Asp Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Asp Lys Cys 
                805                 810                 815     


Arg Asn Asp Lys Thr Gln Lys Phe Tyr Ser Ala Glu Arg Glu Tyr Thr 
            820                 825                 830         


Phe Glu Glu Glu Lys Leu Asn Phe His Ile Asn Thr Lys Ser Lys Phe 
        835                 840                 845             


Glu Glu Tyr Ile Asn Pro Glu Phe Ala Glu Lys Val Phe Arg Leu Lys 
    850                 855                 860                 


Asn Gln Asn Arg Glu Lys Asp Asn Ile Ser Gly Arg Arg Leu Pro Pro 
865                 870                 875                 880 


Leu Lys Met Lys Glu Val Thr Lys Asn Met Val Lys Arg Ile Gly Asn 
                885                 890                 895     


Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Leu Met Leu 
            900                 905                 910         


Leu Met Phe Glu Lys Leu Val Asp Asn Asn Leu Lys Leu Lys Leu Glu 
        915                 920                 925             


Asn Val Asp Lys Leu Leu Asn Glu Ser Ile Glu Ile Asn Gln Ser Ile 
    930                 935                 940                 


Ser Gly Lys Leu Ser Phe Asp Asp Ser Gly Asp Asn Glu Asn Lys Lys 
945                 950                 955                 960 


Asp Arg Ala Ile Ile Cys Arg Asn Ile Thr Glu Thr Arg Lys Arg Lys 
                965                 970                 975     


Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Glu Glu Glu  Asn Ile Pro Ile Glu  Lys Ile Lys 
        995                 1000                 1005             


Ile Glu  Leu Asp Thr Tyr Ser  Lys Ala Lys Asp Val  Val Phe Asp 
    1010                 1015                 1020             


Leu Ile  Phe Asp Leu Glu Arg  Ala Ile Ile Asn Lys  Asp Glu Asn 
    1025                 1030                 1035             


Arg Ile  Lys Glu Leu Asn Lys  Asp Lys Asn Gly Val  Ile Gln Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Phe Trp Leu  Leu Glu Lys 
    1055                 1060                 1065             


Asn Leu  Ile Thr Glu Gln Glu  Phe Thr Phe Met Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Thr  Phe Ser His Asn Gln  Phe Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Leu Phe  Ile Lys Asn Trp Asn  Glu Asn Glu Phe Ala  Lys Gln Ile 
    1100                 1105                 1110             


Leu Asn  Val Tyr Asn Gln Lys  Asn Asn Asn Leu Ile  Lys Ser Ile 
    1115                 1120                 1125             


Lys Asp  Ile 
    1130     


<210>  2679
<211>  1029
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2679

Met His Val Thr Thr Thr Asn Lys Pro Leu Leu Ala Ala Tyr Leu Asn 
1               5                   10                  15      


Met Ala Arg Asn Asn Cys Tyr Met Ala Leu Ser His Ile Ala Glu Leu 
            20                  25                  30          


Met Gly Lys Ser Ser Val Met Asn Glu Asp Ala Ile Gln Glu Cys Ala 
        35                  40                  45              


Val Ile Arg Ala Leu Ala Gly Asn Ile Lys Pro Asp Glu Ser Phe Arg 
    50                  55                  60                  


Ile Ile Asp Met Val Asp Gln His Phe Pro Phe Ile Arg Leu Leu Leu 
65                  70                  75                  80  


Lys Ser Arg Asn Asn Ser Ser Pro Thr Asp Tyr Ala Asn Cys Leu Thr 
                85                  90                  95      


Asp Phe Ile Lys Gln Leu Asn Glu Leu Arg Asn Phe His Thr His Gln 
            100                 105                 110         


Leu His Lys Pro Tyr Ile Thr Asp Ala Lys Val Val Ala Gln Leu Gln 
        115                 120                 125             


Phe Leu Phe Asp Ala Ser Arg Arg Glu Val Lys Lys Arg Phe Ser Leu 
    130                 135                 140                 


Glu Glu Gln Asp Val Lys His Leu Val Arg Lys Ser Ile Val Ile Ile 
145                 150                 155                 160 


Asp Asn Asn Lys Val Ala Val Glu Lys Glu Asn Tyr Val Tyr Ala Phe 
                165                 170                 175     


Ala Asn Lys Glu Gly Gln Phe Thr Asn Lys Gly Ile Ala Phe Leu Ile 
            180                 185                 190         


Ser Leu Phe Ile Glu Lys Lys Tyr Ala Tyr Leu Phe Leu Lys Gln Leu 
        195                 200                 205             


Ser Gly Phe Lys Asn Ser Asn Thr Lys Gln His Lys Ala Thr Leu Glu 
    210                 215                 220                 


Val Phe Cys Phe Tyr His Ile Arg Ile Pro Gln Pro Lys Leu Gln Ser 
225                 230                 235                 240 


Asn Asn Thr Lys Ile Gly Phe Leu Leu Asp Ala Leu Glu Glu Leu Lys 
                245                 250                 255     


Arg Cys Pro Ala Glu Leu Tyr Glu His Ile Ala Lys Asn Asp Lys Gln 
            260                 265                 270         


Arg Phe Lys Ser Ala Gly Ile Thr Glu Asp Thr Asn Asp Gln Pro Glu 
        275                 280                 285             


Ala Ile Leu Lys Arg Asn Gly Asp Arg Phe Ser Tyr Leu Ala Leu Arg 
    290                 295                 300                 


Tyr Leu Glu Leu Thr Asn Ser Leu Pro Gly Leu Gln Phe Tyr Phe Asp 
305                 310                 315                 320 


Leu Gly Lys Tyr Tyr Phe Lys Val Tyr Glu Lys Ser Ile Asp Ser Glu 
                325                 330                 335     


Leu Arg Leu Arg Arg Leu His Lys Asn Met Arg Asp Phe Gly Arg Thr 
            340                 345                 350         


Asn Asp Phe Asp Thr Val Lys Met Pro Gln Leu Trp Gln Gln Leu Ile 
        355                 360                 365             


Lys Arg Thr Asp Glu Leu Ser Glu Asn Tyr Ala Glu Pro Tyr Ile Val 
    370                 375                 380                 


Tyr Thr Ile Pro His Tyr His Ile Val Asn Asn Gln Ile Gly Ile Trp 
385                 390                 395                 400 


Leu Asn Lys Glu Arg Gln Met Pro Ser Leu Thr Pro Lys Ile Ser Asn 
                405                 410                 415     


Ala Glu Pro Gln Ile Trp Leu Ser Leu Tyr Glu Leu Pro Ala Leu Leu 
            420                 425                 430         


Phe Tyr His Leu Leu Thr Lys Gly Asn Lys Gly Gln Lys Asn Val Leu 
        435                 440                 445             


Gln Ile Leu Ser Lys His Arg Thr Ala Ile His Ser Phe Phe Lys Asp 
    450                 455                 460                 


Ile Glu Ser Ser Lys Leu Leu Pro Gly Phe Thr Ile Glu Thr Leu Asn 
465                 470                 475                 480 


Val Glu Leu Glu Lys Arg Asn Leu Lys His Asp Lys Ile Pro Lys Pro 
                485                 490                 495     


Leu Leu Gln Tyr Leu Leu Gln Gln Lys Pro Leu Lys Ser Ile Val Glu 
            500                 505                 510         


Ile Ala Gly Glu Arg Leu Ser Glu Leu Gln Asn Glu Thr Ile Phe Leu 
        515                 520                 525             


Leu Asp Lys Ile Asp Ile Asp Ile Glu Lys Ala Lys Glu Lys Ile Gly 
    530                 535                 540                 


Gly Lys His Tyr Arg Pro Ile Gln Thr Gly Lys Ile Ala Asp Phe Leu 
545                 550                 555                 560 


Ala Arg Asp Met Leu Phe Phe Gln Pro Ala Ile Asp Lys Ile Lys Gly 
                565                 570                 575     


Lys Ala Thr Ser Thr Leu Phe Gln Val Leu Gln Ala Arg Leu Ala Phe 
            580                 585                 590         


Tyr Gly Arg Asp Lys Glu Leu Leu Glu Gly Leu Tyr Lys Glu Cys Asn 
        595                 600                 605             


Leu Ile Gln Ser Lys Asn Pro His Pro Phe Leu Ser Gly Leu Pro Ile 
    610                 615                 620                 


Thr Asn Asn Leu Met Asp Tyr Tyr Arg Asn Tyr Leu Ile Lys Arg Asn 
625                 630                 635                 640 


Gln Tyr Leu Asp Lys Cys Leu Lys Lys Cys Lys Gln Gly Lys Ile Gly 
                645                 650                 655     


Ser Gln Asp Phe His Phe Leu His Leu Gly Glu Arg Glu Arg Lys Asn 
            660                 665                 670         


Gly Asn Thr Tyr Tyr Thr Asn Leu Ala Gly Lys Phe Ile Lys Met Pro 
        675                 680                 685             


Leu Asn Phe Pro Arg Gly Leu Phe Met Glu Glu Leu Ile Asn Tyr Phe 
    690                 695                 700                 


Glu Ser Ser Gly Asp Leu His Met Gln Asn Ile Ile Lys Asn Thr Pro 
705                 710                 715                 720 


Arg Leu Ser Thr Thr Phe Leu Leu Lys Glu Tyr Ile Asn Asn Val Leu 
                725                 730                 735     


Ser Asp Asp Thr Pro Asp Phe Tyr Asn Trp Lys Arg Ser Tyr Thr Val 
            740                 745                 750         


Phe Asn Arg Tyr Tyr Asp Lys Arg Lys Gln Asn Ser Arg Asp Ala Ile 
        755                 760                 765             


Thr Lys Ile Tyr Phe Asp Thr Ser Gln Leu Ser Glu Glu Ala Asn Lys 
    770                 775                 780                 


Ile Lys Ala Ala Ile Lys Lys Ile Glu Lys Ser Asp Ile Lys Gly Ala 
785                 790                 795                 800 


Glu Ser Ile Lys Arg Asn Tyr Lys Phe Tyr Gly Asp Asn Glu Lys Gln 
                805                 810                 815     


Leu Arg Gln Ala Lys Ala Cys Asp Thr Ile Leu Phe Leu Ala Ile Arg 
            820                 825                 830         


Asp Leu Phe Pro Thr Ile Glu Ser Ser Val Phe Lys Gly Leu Ala Ile 
        835                 840                 845             


Glu Gln Phe Arg Leu Ser Asp Ile Leu Pro Asp Ala Glu Lys Gly Ile 
    850                 855                 860                 


Leu Ser Gln Ser Ile Glu Ile Arg Leu Pro Leu Tyr Asn Lys Phe Ile 
865                 870                 875                 880 


Ile Gln Lys Gly Leu Lys Leu Lys Asn Tyr Gly Asp Phe Arg Arg Phe 
                885                 890                 895     


Leu Lys Asp Arg Arg Leu Glu Ser Leu Met Pro Tyr Phe Glu Glu Asp 
            900                 905                 910         


Asp Ile Asp Arg Ser Ser Leu Glu Lys Glu Leu Glu Asp Tyr Asp Thr 
        915                 920                 925             


Ala Arg Ile Glu Ile His Arg Val Val Leu Asp Phe Glu Ser His Val 
    930                 935                 940                 


Ile Thr Met Tyr Gln Leu Asn Tyr Leu Asn Pro Glu Asp Pro Cys Ile 
945                 950                 955                 960 


Asn His Glu Thr Ile Leu Asn Cys Phe Phe Gln Asn Asp Pro Ser Asp 
                965                 970                 975     


Ile Arg Lys Gln Leu Met Glu Asn Ile Arg Asn Arg Phe Ser His Asn 
            980                 985                 990         


Glu Tyr Pro Asp Phe Glu Lys Phe  Lys Glu Ile Ile Gln  Glu Asn His 
        995                 1000                 1005             


Gln Gln  Lys Thr Ile Ala Gly  Lys Phe Val Thr Leu  Ala Asn Gln 
    1010                 1015                 1020             


Tyr Phe  Ser Val Glu Glu 
    1025                 


<210>  2680
<211>  1082
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2680

Met Ile Phe Leu Asn Leu Ala Arg His Asn Val Tyr Thr Thr Val Asn 
1               5                   10                  15      


His Ile Asn Lys Leu Leu Glu Ile Ala Glu Leu Lys Asn Asp Glu Asp 
            20                  25                  30          


Val Leu Asn Ile Lys Asp Ser Trp Asn Lys Gln Ala Glu Lys Leu Asp 
        35                  40                  45              


Lys Lys Val Arg Leu Arg Asp Leu Ile Met Lys His Phe Leu Phe Leu 
    50                  55                  60                  


Glu Ala Ala Ala Tyr Glu Ile Thr Asn Ser Lys Ser Pro Asn Asn Lys 
65                  70                  75                  80  


Glu Gln Arg Glu Lys Glu Gln Ser Glu Ala Leu Ser Leu Asn Asn Leu 
                85                  90                  95      


Lys Asn Val Leu Phe Ile Phe Leu Glu Lys Leu Gln Val Leu Arg Asn 
            100                 105                 110         


Tyr Tyr Ser His Tyr Lys Tyr Ser Glu Glu Ser Pro Lys Pro Ile Phe 
        115                 120                 125             


Glu Thr Ser Leu Leu Lys Asn Met Tyr Lys Val Phe Asp Thr Asn Val 
    130                 135                 140                 


Arg Leu Val Lys Arg Asp Tyr Met His His Glu Asn Ile Asp Met Gln 
145                 150                 155                 160 


Arg Asp Phe Thr His Leu Asn Arg Lys Lys Gln Val Gly Arg Thr Lys 
                165                 170                 175     


Asn Ile Ile Asp Ser Pro Asn Phe His Tyr His Phe Ala Asp Lys Glu 
            180                 185                 190         


Gly Asn Met Thr Ile Ala Gly Leu Leu Phe Phe Val Ser Leu Phe Leu 
        195                 200                 205             


Asp Lys Lys Asp Ala Ile Trp Met Gln Lys Lys Leu Lys Gly Phe Lys 
    210                 215                 220                 


Asp Ser Arg Asn Leu His Glu Gln Met Thr Asn Glu Val Phe Cys Arg 
225                 230                 235                 240 


Asn Arg Ile Tyr Leu Pro Lys Leu Lys Met Glu Thr Val Gln Thr Arg 
                245                 250                 255     


Glu Trp Met Gln Leu Asp Met Leu Asn Glu Leu Ile Arg Cys Pro Lys 
            260                 265                 270         


Ser Leu Tyr Glu Arg Leu Arg Glu Glu Asp Arg Glu Ser Phe Lys Val 
        275                 280                 285             


Pro Phe Asp Ile Phe Ser Asp Asp Tyr Asn Ala Glu Glu Glu Pro Phe 
    290                 295                 300                 


Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Val Leu 
305                 310                 315                 320 


Arg Tyr Phe Asp Leu Asn Glu Ile Phe Thr Gln Leu Arg Phe Gln Ile 
                325                 330                 335     


Asp Leu Gly Thr Tyr His Phe Ser Ile Tyr Asn Lys Arg Ile Gly Asp 
            340                 345                 350         


Glu Asp Glu Val Arg His Leu Thr His His Leu Tyr Gly Phe Ala Arg 
        355                 360                 365             


Ile Gln Asp Phe Ala Gln Gln Asn Gln Pro Glu Val Trp Arg Lys Leu 
    370                 375                 380                 


Val Lys Asp Leu Asp Tyr Phe Glu Val Ser Gln Glu Pro Tyr Ile Ser 
385                 390                 395                 400 


Lys Thr Thr Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Lys 
                405                 410                 415     


Phe Cys Ser Ala His Asn Asn Leu Phe Pro Ser Leu Gln Thr Asp Lys 
            420                 425                 430         


Thr Cys Asn Gly Arg Ser Lys Phe Asn Leu Gly Thr Gln Phe Thr Ala 
        435                 440                 445             


Glu Ala Phe Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr 
    450                 455                 460                 


Leu Leu Leu Thr Lys Asp Tyr Ser Lys Lys Glu Ser Ala Asp Lys Val 
465                 470                 475                 480 


Glu Gly Ile Ile Arg Lys Glu Ile Ser Asn Ile Tyr Ala Ile Tyr Asp 
                485                 490                 495     


Ala Phe Ala Asn Gly Glu Ile Asn Ser Ile Ala Asp Leu Thr Arg Arg 
            500                 505                 510         


Leu Gln Asn Thr Asn Ile Leu Gln Gly His Leu Pro Lys Gln Met Ile 
        515                 520                 525             


Ser Ile Leu Lys Gly Arg Gln Lys Asp Met Glu Lys Glu Ala Glu Arg 
    530                 535                 540                 


Lys Ile Gly Glu Met Ile Asp Asp Thr Gln Arg Arg Leu Asp Leu Leu 
545                 550                 555                 560 


Tyr Lys Gln Val Asn Gln Lys Ile Arg Ile Gly Lys Arg Asn Ala Gly 
                565                 570                 575     


Leu Leu Lys Ser Gly Lys Ile Ala Asp Trp Leu Val Ser Asp Met Met 
            580                 585                 590         


Arg Phe Gln Pro Val Gln Lys Asp Thr Asn Asn Ala Pro Ile Asn Asn 
        595                 600                 605             


Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu Gln His Ala Leu Ala 
    610                 615                 620                 


Leu Phe Gly Ser Glu Ser Ser Arg Leu Lys Ala Tyr Phe Arg Gln Met 
625                 630                 635                 640 


Asn Leu Val Gly Asn Ala Asn Pro His Pro Phe Leu Ala Glu Thr Gln 
                645                 650                 655     


Trp Glu His Gln Asn Asn Ile Leu Tyr Phe Tyr Arg Lys Tyr Leu Glu 
            660                 665                 670         


Ala Arg Lys Lys Tyr Leu Lys Gly Leu Lys Pro Gln Asn Trp Lys Gln 
        675                 680                 685             


Tyr Gln His Phe Leu Met Leu Lys Glu Gln Lys Ser Asn Arg Asn Thr 
    690                 695                 700                 


Leu Val Ala Gly Trp Lys Asn Gly Phe Asn Leu Pro Arg Gly Ile Phe 
705                 710                 715                 720 


Thr Glu Pro Ile Arg Lys Trp Phe Glu Glu His Asn Asn Ser Glu Gly 
                725                 730                 735     


Leu Tyr Asp Gln Ile Leu Ser Phe Gly Arg Val Gly Phe Val Ala Lys 
            740                 745                 750         


Ala Ile Pro Leu Tyr Phe Ala Glu Glu Cys Lys Asp Cys Val Gln Pro 
        755                 760                 765             


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Lys Leu Lys Pro Lys Lys 
    770                 775                 780                 


Gly Gln Phe Leu Asp Lys Lys Asp Arg Val Glu Leu Trp Arg Lys Asn 
785                 790                 795                 800 


Lys Glu Leu Phe Lys Asn Tyr Pro Pro Glu Lys Arg Lys Thr Asp Leu 
                805                 810                 815     


Ala Tyr Leu Asp Phe Leu Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg 
            820                 825                 830         


Leu Ile Lys Asn Gln Asp Ile Val Thr Trp Leu Met Phe Lys Glu Leu 
        835                 840                 845             


Phe Lys Thr Thr Thr Val Glu Gly Leu Lys Ile Gly Glu Ile His Leu 
    850                 855                 860                 


Arg Asp Ile Asp Thr Asn Thr Ala Asn Glu Glu Ser Asn Asn Ile Leu 
865                 870                 875                 880 


Asn Arg Ile Met Pro Met Lys Leu Pro Val Lys Thr Tyr Glu Thr Asp 
                885                 890                 895     


Asn Lys Gly Asn Ile Leu Lys Glu Arg Pro Leu Ala Thr Phe Tyr Ile 
            900                 905                 910         


Glu Glu Thr Glu Thr Lys Val Leu Lys Gln Gly Asn Phe Lys Val Leu 
        915                 920                 925             


Ala Lys Asp Arg Arg Leu Asn Gly Leu Leu Ser Phe Ala Glu Thr Thr 
    930                 935                 940                 


Asp Ile Asp Leu Glu Lys Asn Pro Ile Thr Lys Leu Ser Val Asp His 
945                 950                 955                 960 


Glu Leu Ile Lys Tyr Gln Thr Thr Arg Ile Ser Ile Phe Glu Met Thr 
                965                 970                 975     


Leu Gly Leu Glu Lys Lys Leu Ile Asp Lys Tyr Ser Thr Leu Pro Thr 
            980                 985                 990         


Asp Ser Phe Arg Asn Met Leu Glu  Arg Trp Leu Gln Cys  Lys Ala Asn 
        995                 1000                 1005             


Arg Pro  Glu Leu Lys Asn Tyr  Val Asn Ser Leu Ile  Ala Val Arg 
    1010                 1015                 1020             


Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met Tyr Asp  Ala Thr Leu 
    1025                 1030                 1035             


Phe Ala  Glu Val Lys Lys Phe  Thr Leu Phe Pro Ser  Val Asp Thr 
    1040                 1045                 1050             


Lys Lys  Ile Glu Leu Asn Ile  Ala Pro Gln Leu Leu  Glu Ile Val 
    1055                 1060                 1065             


Gly Lys  Ala Ile Lys Glu Ile  Glu Lys Ser Glu Asn  Lys Asn 
    1070                 1075                 1080         


<210>  2681
<211>  1131
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2681

Met Glu Lys Thr Ile Glu Asn Gln Thr Gln Ser Lys Arg Thr Leu Asn 
1               5                   10                  15      


Asn Thr Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Asp Glu Glu Lys Ile Thr Thr Ser Phe Leu Val Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Arg Gln Ser Leu Val Tyr Ser Asn Leu Thr 
65                  70                  75                  80  


Arg Tyr Met His Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Asp 
                85                  90                  95      


Asp Glu Arg Asp Lys Ala Glu Asn Tyr Gly Lys Asp Phe Gly Asn Leu 
            100                 105                 110         


Thr Asp Thr Leu Lys Glu Ile Phe Lys Glu Leu Asn Glu Phe Arg Asn 
        115                 120                 125             


Asp Tyr Ser His Tyr Tyr Ser Thr Glu Lys Lys Asp Lys Arg Lys Thr 
    130                 135                 140                 


Ile Val Ser Asp Lys Leu Lys Asn Phe Leu Asn Ile Asn Tyr Thr Arg 
145                 150                 155                 160 


Ala Ile Lys Tyr Thr Lys Ser Arg Phe Ile Asn Val Phe Ser Asp Asn 
                165                 170                 175     


Asn Phe Cys Leu Ala Glu Glu Ala Lys His Val Glu Asn Asp Asn Thr 
            180                 185                 190         


Ile Thr Gln Asp Gly Ile Val Phe Phe Thr Ser Met Phe Leu Asp Arg 
        195                 200                 205             


Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile Ile Gly Leu Lys Gly Thr 
    210                 215                 220                 


Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Thr Leu Met Ala Phe Cys 
225                 230                 235                 240 


Val Asn Leu Pro His Asp Lys Phe Val Ser Glu Asn Ser Glu Gln Gln 
                245                 250                 255     


Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu 
            260                 265                 270         


Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln His Phe Leu Pro Lys Leu 
        275                 280                 285             


Asp Asp Glu Gln Ile Asp Asn Val Leu Glu Asn Ser Val Pro Tyr Thr 
    290                 295                 300                 


Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn Ile Thr Lys Lys Val Arg 
305                 310                 315                 320 


Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu Lys Phe Ile Asp Gln Lys 
                325                 330                 335     


Lys Leu Phe Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val 
            340                 345                 350         


Leu Asp Glu Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Lys Arg Thr 
        355                 360                 365             


Val Thr Glu Asn Thr Lys Ala Phe Gly Met Leu Gln Asp Leu Asn Asp 
    370                 375                 380                 


Glu Glu Asn Val Leu Asn Lys Ile Asn Thr Gly Glu Ser Lys Ala Lys 
385                 390                 395                 400 


Phe Asp Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Thr Lys Asn 
            420                 425                 430         


Thr Asp Asn Lys Ile Lys Ser Asn Leu Leu Gln Pro Leu Pro Glu Ala 
        435                 440                 445             


Phe Leu Ser Ile Asn Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
    450                 455                 460                 


Glu Gln Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn 
465                 470                 475                 480 


Asn Ser Lys Ile Leu Asn Lys Glu Phe Ile Lys Ala Ile Lys Leu Lys 
                485                 490                 495     


Leu Asn Asp Leu Asp Val Phe Tyr Lys Arg Ser Gln Gly Arg Lys Gln 
            500                 505                 510         


Lys His Ala Tyr Leu Thr Lys Asp Lys Lys Tyr Asp Asn Glu Lys Ile 
        515                 520                 525             


Asn Glu Leu Lys Asn Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu 
    530                 535                 540                 


Tyr Asn Leu Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp 
545                 550                 555                 560 


Leu Asn Ile Ala Asp Val Gln Ala Lys Asn Ala Ile Ser Asp Arg Ile 
                565                 570                 575     


Lys Leu Met Lys Arg Asp Cys Ile Asn Arg Leu Lys Ser Met Lys Lys 
            580                 585                 590         


Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp 
        595                 600                 605             


Ile Val Asp Met Ile Ile Asp Glu Glu Lys Lys Lys Lys Ile Thr Ser 
    610                 615                 620                 


Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Lys 
625                 630                 635                 640 


Glu Lys Lys Glu Leu Phe Ile Leu Ile Cys Asn Asn Glu Leu Lys Leu 
                645                 650                 655     


Asn Asp Asp Asp Gly His Pro Phe Phe Lys Asn Ile Asn Phe Ser Asn 
            660                 665                 670         


Tyr Lys Tyr Thr Ser Glu Ile Tyr Gln Lys Tyr Leu Glu Glu Lys Gly 
        675                 680                 685             


His Lys Met Val Lys Glu Tyr Asn Pro Arg Lys Glu Asn Tyr Val Glu 
    690                 695                 700                 


Lys Asp Lys Ser Trp Leu Glu Ile Asn Phe Tyr Lys Lys Glu Trp Asn 
705                 710                 715                 720 


Glu Asn Ala Lys Lys Asp Leu Thr Val Val Lys Leu Pro Asp Asp Lys 
                725                 730                 735     


Ser Lys Ile Pro Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser 
            740                 745                 750         


Phe Glu Asn Trp Phe Lys Tyr Val Thr Asn Gly Lys Glu Thr Thr Asp 
        755                 760                 765             


Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp Glu Thr Leu 
    770                 775                 780                 


Lys Glu Leu Leu Lys Lys Glu Leu Ser Lys Asn Asn Ile Glu Phe Lys 
785                 790                 795                 800 


Glu Glu Asp Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Asp Lys Cys 
                805                 810                 815     


Arg Asn Asp Lys Thr Gln Lys Phe Tyr Ser Ala Glu Arg Glu Tyr Thr 
            820                 825                 830         


Phe Glu Glu Glu Lys Leu Asn Phe His Ile Asn Thr Lys Ser Lys Phe 
        835                 840                 845             


Glu Glu Tyr Ile Asn Pro Glu Phe Ala Glu Lys Val Phe Arg Leu Lys 
    850                 855                 860                 


Asn Gln Asn Arg Glu Lys Asp Asn Ile Ser Gly Arg Arg Leu Pro Pro 
865                 870                 875                 880 


Leu Lys Met Lys Glu Val Thr Lys Asn Met Val Lys Arg Ile Gly Asn 
                885                 890                 895     


Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Leu Met Leu 
            900                 905                 910         


Leu Met Phe Glu Lys Leu Val Asp Asn Asn Leu Lys Leu Lys Leu Glu 
        915                 920                 925             


Asn Val Asp Lys Leu Leu Asn Glu Ser Ile Glu Ile Asn Gln Ser Ile 
    930                 935                 940                 


Ser Gly Lys Leu Ser Phe Asp Asp Ser Gly Asp Asn Glu Asn Lys Lys 
945                 950                 955                 960 


Asp Arg Ala Ile Ile Cys Arg Asn Ile Thr Glu Thr Arg Lys Arg Lys 
                965                 970                 975     


Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Glu Glu Glu  Asn Ile Pro Ile Glu  Lys Ile Lys 
        995                 1000                 1005             


Ile Glu  Leu Asp Thr Tyr Ser  Lys Ala Lys Asp Val  Val Phe Asp 
    1010                 1015                 1020             


Leu Ile  Phe Asp Leu Glu Arg  Ala Ile Ile Asn Lys  Asp Glu Asn 
    1025                 1030                 1035             


Arg Ile  Lys Glu Leu Asn Lys  Asp Lys Asn Gly Val  Ile Gln Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Phe Trp Leu  Leu Glu Lys 
    1055                 1060                 1065             


Asn Leu  Ile Thr Glu Gln Glu  Phe Thr Phe Met Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Thr  Phe Ser His Asn Gln  Phe Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Leu Phe  Ile Lys Asn Trp Asn  Glu Asn Glu Phe Ala  Lys Gln Ile 
    1100                 1105                 1110             


Leu Asn  Val Tyr Asn Gln Lys  Asn Asn Asn Leu Ile  Lys Ser Ile 
    1115                 1120                 1125             


Lys Asp  Ile 
    1130     


<210>  2682
<211>  1131
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2682

Met Glu Lys Thr Ile Glu Asn Gln Thr Gln Ser Lys Arg Thr Leu Asn 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Asp Glu Glu Lys Ile Thr Thr Ser Phe Leu Val Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Arg Gln Ser Leu Val Tyr Ser Asn Leu Thr 
65                  70                  75                  80  


Arg Tyr Met His Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Asp 
                85                  90                  95      


Asp Glu Arg Asp Lys Ala Glu Asn Tyr Gly Lys Asp Phe Gly Asn Leu 
            100                 105                 110         


Thr Asp Thr Leu Lys Glu Ile Phe Lys Glu Leu Asn Glu Phe Arg Asn 
        115                 120                 125             


Asp Tyr Ser His Tyr Tyr Ser Thr Glu Lys Lys Asp Lys Arg Lys Thr 
    130                 135                 140                 


Ile Val Ser Asp Lys Leu Lys Asn Phe Leu Asn Ile Asn Tyr Thr Arg 
145                 150                 155                 160 


Ala Ile Lys Tyr Thr Lys Ser Arg Phe Ile Asn Val Phe Ser Asp Asn 
                165                 170                 175     


Asn Phe Cys Leu Ala Glu Glu Ala Lys His Val Glu Asn Asp Asn Thr 
            180                 185                 190         


Ile Thr Gln Asp Gly Ile Val Phe Phe Thr Ser Met Phe Leu Asp Arg 
        195                 200                 205             


Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile Ile Gly Leu Lys Gly Thr 
    210                 215                 220                 


Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Thr Leu Met Ala Phe Cys 
225                 230                 235                 240 


Val Asn Leu Pro His Asp Lys Phe Val Ser Glu Asn Ser Glu Gln Gln 
                245                 250                 255     


Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu 
            260                 265                 270         


Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln His Phe Leu Pro Lys Leu 
        275                 280                 285             


Asp Asp Glu Gln Ile Asp Asn Val Leu Glu Asn Ser Val Pro Tyr Thr 
    290                 295                 300                 


Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn Ile Thr Lys Lys Val Arg 
305                 310                 315                 320 


Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu Lys Phe Ile Asp Gln Lys 
                325                 330                 335     


Lys Leu Phe Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val 
            340                 345                 350         


Leu Asp Glu Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Lys Arg Thr 
        355                 360                 365             


Val Thr Glu Asn Thr Lys Ala Phe Gly Met Leu Gln Asp Leu Asn Asp 
    370                 375                 380                 


Glu Glu Asn Val Leu Asn Lys Ile Asn Thr Gly Glu Ser Lys Ala Lys 
385                 390                 395                 400 


Phe Asp Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Thr Lys Asn 
            420                 425                 430         


Thr Asp Asn Lys Ile Lys Ser Asn Leu Leu Gln Pro Leu Pro Glu Ala 
        435                 440                 445             


Phe Leu Ser Ile Asn Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
    450                 455                 460                 


Glu Gln Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn 
465                 470                 475                 480 


Asn Ser Lys Ile Leu Asn Lys Glu Phe Ile Lys Ala Ile Lys Leu Lys 
                485                 490                 495     


Leu Asn Asp Leu Asp Val Phe Tyr Lys Arg Ser Gln Gly Arg Lys Gln 
            500                 505                 510         


Lys His Ala Tyr Leu Thr Lys Asp Lys Lys Tyr Asp Asn Glu Lys Ile 
        515                 520                 525             


Asn Glu Leu Lys Asn Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu 
    530                 535                 540                 


Tyr Asn Leu Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp 
545                 550                 555                 560 


Leu Asn Ile Ala Asp Val Gln Ala Lys Asn Ala Ile Ser Asp Arg Ile 
                565                 570                 575     


Lys Leu Met Lys Arg Asp Cys Ile Asn Arg Leu Lys Ser Met Lys Lys 
            580                 585                 590         


Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp 
        595                 600                 605             


Ile Val Asp Met Ile Ile Asp Glu Glu Lys Lys Lys Lys Ile Thr Ser 
    610                 615                 620                 


Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Lys 
625                 630                 635                 640 


Glu Lys Lys Glu Leu Phe Ile Leu Ile Cys Asn Asn Glu Leu Lys Leu 
                645                 650                 655     


Asn Asp Asp Asp Gly His Pro Phe Phe Lys Asn Ile Asn Phe Ser Asn 
            660                 665                 670         


Tyr Lys Tyr Thr Ser Glu Ile Tyr Gln Lys Tyr Leu Glu Glu Lys Gly 
        675                 680                 685             


His Lys Met Val Lys Glu Tyr Asn Pro Arg Lys Glu Asn Tyr Val Glu 
    690                 695                 700                 


Lys Asp Lys Ser Trp Leu Glu Ile Asn Phe Tyr Lys Lys Glu Trp Asn 
705                 710                 715                 720 


Glu Asn Ala Lys Lys Asp Leu Thr Val Val Lys Leu Pro Asp Asp Lys 
                725                 730                 735     


Ser Lys Ile Pro Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser 
            740                 745                 750         


Phe Glu Asn Trp Phe Lys Tyr Val Thr Asn Gly Lys Glu Thr Thr Asp 
        755                 760                 765             


Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp Glu Thr Leu 
    770                 775                 780                 


Lys Glu Leu Leu Lys Lys Glu Leu Ser Lys Asn Asn Ile Glu Phe Lys 
785                 790                 795                 800 


Glu Glu Asp Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Asp Lys Cys 
                805                 810                 815     


Arg Asn Asp Lys Thr Gln Lys Phe Tyr Ser Ala Glu Arg Glu Tyr Thr 
            820                 825                 830         


Phe Glu Glu Glu Lys Leu Asn Phe His Ile Asn Thr Lys Ser Lys Phe 
        835                 840                 845             


Glu Glu Tyr Ile Asn Pro Glu Phe Ala Glu Lys Val Phe Arg Leu Lys 
    850                 855                 860                 


Asn Gln Asn Arg Glu Lys Asp Asn Ile Ser Gly Arg Arg Leu Pro Pro 
865                 870                 875                 880 


Leu Lys Met Lys Glu Val Thr Lys Asn Met Val Lys Arg Ile Gly Asn 
                885                 890                 895     


Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Leu Met Leu 
            900                 905                 910         


Leu Met Phe Glu Lys Leu Val Asp Asn Asn Leu Lys Leu Lys Leu Glu 
        915                 920                 925             


Asn Val Asp Lys Leu Leu Asn Glu Ser Ile Glu Ile Asn Gln Ser Ile 
    930                 935                 940                 


Ser Gly Lys Leu Ser Phe Asp Asp Ser Gly Asp Asn Glu Asn Lys Lys 
945                 950                 955                 960 


Asp Arg Ala Ile Ile Cys Arg Asn Ile Thr Glu Thr Arg Lys Arg Lys 
                965                 970                 975     


Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Glu Glu Glu  Asn Ile Pro Ile Glu  Lys Ile Lys 
        995                 1000                 1005             


Ile Glu  Leu Asp Thr Tyr Ser  Lys Ala Lys Asp Val  Val Phe Asp 
    1010                 1015                 1020             


Leu Ile  Phe Asp Leu Glu Arg  Ala Ile Ile Asn Lys  Asp Glu Asn 
    1025                 1030                 1035             


Arg Ile  Lys Glu Leu Asn Lys  Asp Lys Asn Gly Val  Ile Gln Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Phe Trp Leu  Leu Glu Lys 
    1055                 1060                 1065             


Asn Leu  Ile Thr Glu Gln Glu  Phe Thr Phe Met Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Thr  Phe Ser His Asn Gln  Phe Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Leu Phe  Ile Lys Asn Trp Asn  Glu Asn Glu Phe Ala  Lys Gln Ile 
    1100                 1105                 1110             


Leu Asn  Val Tyr Asn Gln Lys  Asn Asn Asn Leu Ile  Lys Ser Ile 
    1115                 1120                 1125             


Lys Asp  Ile 
    1130     


<210>  2683
<211>  1131
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2683

Met Glu Lys Thr Ile Glu Asn Gln Thr Gln Ser Lys Arg Thr Leu Asn 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Asp Glu Glu Lys Ile Thr Thr Ser Phe Leu Val Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Arg Gln Ser Leu Val Tyr Ser Asn Leu Thr 
65                  70                  75                  80  


Arg Tyr Met His Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Asp 
                85                  90                  95      


Asp Glu Arg Asp Lys Ala Glu Asn Tyr Gly Lys Asp Phe Gly Asn Leu 
            100                 105                 110         


Thr Asp Thr Leu Lys Glu Ile Phe Lys Glu Leu Asn Glu Phe Arg Asn 
        115                 120                 125             


Asp Tyr Ser His Tyr Tyr Ser Thr Glu Lys Lys Asp Lys Arg Lys Thr 
    130                 135                 140                 


Ile Val Ser Asp Lys Leu Lys Asn Phe Leu Asn Ile Asn Tyr Thr Arg 
145                 150                 155                 160 


Ala Ile Lys Tyr Thr Lys Ser Arg Phe Ile Asn Val Phe Ser Asp Asn 
                165                 170                 175     


Asn Phe Cys Leu Ala Glu Glu Ala Lys His Val Glu Asn Asp Asn Thr 
            180                 185                 190         


Ile Thr Gln Asp Gly Ile Val Phe Phe Thr Ser Met Phe Leu Asp Arg 
        195                 200                 205             


Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile Ile Gly Leu Lys Gly Thr 
    210                 215                 220                 


Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Thr Leu Met Ala Phe Cys 
225                 230                 235                 240 


Val Asn Leu Pro His Asp Lys Phe Val Ser Glu Asn Ser Glu Gln Gln 
                245                 250                 255     


Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu 
            260                 265                 270         


Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln His Phe Leu Pro Lys Leu 
        275                 280                 285             


Asp Asp Glu Gln Ile Asp Asn Val Leu Glu Asn Ser Val Pro Tyr Thr 
    290                 295                 300                 


Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn Ile Thr Lys Lys Val Arg 
305                 310                 315                 320 


Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu Lys Phe Ile Asp Gln Lys 
                325                 330                 335     


Lys Leu Phe Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val 
            340                 345                 350         


Leu Asp Glu Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Lys Arg Thr 
        355                 360                 365             


Val Thr Glu Asn Thr Lys Ala Phe Gly Met Leu Gln Asp Leu Asn Asp 
    370                 375                 380                 


Glu Glu Asn Val Leu Asn Lys Ile Asn Thr Gly Glu Ser Lys Ala Lys 
385                 390                 395                 400 


Phe Asp Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Thr Lys Asn 
            420                 425                 430         


Thr Asp Asn Lys Ile Lys Ser Asn Leu Leu Gln Pro Leu Pro Glu Ala 
        435                 440                 445             


Phe Leu Ser Ile Asn Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
    450                 455                 460                 


Glu Gln Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn 
465                 470                 475                 480 


Asn Ser Lys Ile Leu Asn Lys Glu Phe Ile Lys Ala Ile Lys Leu Lys 
                485                 490                 495     


Leu Asn Asp Leu Asp Val Phe Tyr Lys Arg Ser Gln Gly Arg Lys Gln 
            500                 505                 510         


Lys His Ala Tyr Leu Thr Lys Asp Lys Lys Tyr Asp Asn Glu Lys Ile 
        515                 520                 525             


Asn Glu Leu Lys Asn Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu 
    530                 535                 540                 


Tyr Asn Leu Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp 
545                 550                 555                 560 


Leu Asn Ile Ala Asp Val Gln Ala Lys Asn Ala Ile Ser Asp Arg Ile 
                565                 570                 575     


Lys Leu Met Lys Arg Asp Cys Ile Asn Arg Leu Lys Ser Met Lys Lys 
            580                 585                 590         


Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp 
        595                 600                 605             


Ile Val Asp Met Ile Ile Asp Glu Glu Lys Lys Lys Lys Ile Thr Ser 
    610                 615                 620                 


Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Lys 
625                 630                 635                 640 


Glu Lys Lys Glu Leu Phe Ile Leu Ile Cys Asn Asn Glu Leu Lys Leu 
                645                 650                 655     


Asn Asp Asp Asp Gly His Pro Phe Phe Lys Asn Ile Asn Phe Ser Asn 
            660                 665                 670         


Tyr Lys Tyr Thr Ser Glu Ile Tyr Gln Lys Tyr Leu Glu Glu Lys Gly 
        675                 680                 685             


His Lys Met Val Lys Glu Tyr Asn Pro Arg Lys Glu Asn Tyr Val Glu 
    690                 695                 700                 


Lys Asp Lys Ser Trp Leu Glu Ile Asn Phe Tyr Lys Lys Glu Trp Asn 
705                 710                 715                 720 


Glu Asn Ala Lys Lys Asp Leu Thr Val Val Lys Leu Pro Asp Asp Lys 
                725                 730                 735     


Ser Lys Ile Pro Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser 
            740                 745                 750         


Phe Glu Asn Trp Phe Lys Tyr Val Thr Asn Gly Lys Glu Thr Thr Asp 
        755                 760                 765             


Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp Glu Thr Leu 
    770                 775                 780                 


Lys Glu Leu Leu Lys Lys Glu Leu Ser Lys Asn Asn Ile Glu Phe Lys 
785                 790                 795                 800 


Glu Glu Asp Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Asp Lys Cys 
                805                 810                 815     


Arg Asn Asp Lys Thr Gln Lys Phe Tyr Ser Ala Glu Arg Glu Tyr Thr 
            820                 825                 830         


Phe Glu Glu Glu Lys Leu Asn Phe His Ile Asn Thr Lys Ser Lys Phe 
        835                 840                 845             


Glu Glu Tyr Ile Asn Pro Glu Phe Ala Glu Lys Val Phe Arg Leu Lys 
    850                 855                 860                 


Asn Gln Asn Arg Glu Lys Asp Asn Ile Ser Gly Arg Arg Leu Pro Pro 
865                 870                 875                 880 


Leu Lys Met Lys Glu Val Thr Lys Asn Met Val Lys Arg Ile Gly Asn 
                885                 890                 895     


Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Leu Met Leu 
            900                 905                 910         


Leu Met Phe Glu Lys Leu Val Asp Asn Asn Leu Lys Leu Lys Leu Glu 
        915                 920                 925             


Asn Val Asp Lys Leu Leu Asn Glu Ser Ile Glu Ile Asn Gln Ser Ile 
    930                 935                 940                 


Ser Gly Lys Leu Ser Phe Asp Asp Ser Gly Asp Asn Glu Asn Lys Lys 
945                 950                 955                 960 


Asp Arg Ala Ile Ile Cys Arg Asn Ile Thr Glu Thr Arg Lys Arg Lys 
                965                 970                 975     


Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Glu Glu Glu  Asn Ile Pro Ile Glu  Lys Ile Lys 
        995                 1000                 1005             


Ile Glu  Leu Asp Thr Tyr Ser  Lys Ala Lys Asp Val  Val Phe Asp 
    1010                 1015                 1020             


Leu Ile  Phe Asp Leu Glu Arg  Ala Ile Ile Asn Lys  Asp Glu Asn 
    1025                 1030                 1035             


Arg Ile  Lys Glu Leu Asn Lys  Asp Lys Asn Gly Val  Ile Gln Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Phe Trp Leu  Leu Glu Lys 
    1055                 1060                 1065             


Asn Leu  Ile Thr Glu Gln Glu  Phe Thr Phe Met Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Thr  Phe Ser His Asn Gln  Phe Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Leu Phe  Ile Lys Asn Trp Asn  Glu Asn Glu Phe Ala  Lys Gln Ile 
    1100                 1105                 1110             


Leu Asn  Val Tyr Asn Gln Lys  Asn Asn Asn Leu Ile  Lys Ser Ile 
    1115                 1120                 1125             


Lys Asp  Ile 
    1130     


<210>  2684
<211>  1131
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2684

Met Glu Lys Thr Ile Glu Asn Gln Thr Gln Ser Lys Arg Thr Leu Asn 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Asp Glu Glu Lys Ile Thr Thr Ser Phe Leu Val Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Arg Gln Ser Leu Val Tyr Ser Asn Leu Thr 
65                  70                  75                  80  


Arg Tyr Met His Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Asp 
                85                  90                  95      


Asp Glu Arg Asp Lys Ala Glu Asn Tyr Gly Lys Asp Phe Gly Asn Leu 
            100                 105                 110         


Thr Asp Thr Leu Lys Glu Ile Phe Lys Glu Leu Asn Glu Phe Arg Asn 
        115                 120                 125             


Asp Tyr Ser His Tyr Tyr Ser Thr Glu Lys Lys Asp Lys Arg Lys Thr 
    130                 135                 140                 


Ile Val Ser Asp Lys Leu Lys Asn Phe Leu Asn Ile Asn Tyr Thr Arg 
145                 150                 155                 160 


Ala Ile Lys Tyr Thr Lys Ser Arg Phe Ile Asn Val Phe Ser Asp Asn 
                165                 170                 175     


Asn Phe Cys Leu Ala Glu Glu Ala Lys His Val Glu Asn Asp Asn Thr 
            180                 185                 190         


Ile Thr Gln Asp Gly Ile Val Phe Phe Thr Ser Met Phe Leu Asp Arg 
        195                 200                 205             


Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile Ile Gly Leu Lys Gly Thr 
    210                 215                 220                 


Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Thr Leu Met Ala Phe Cys 
225                 230                 235                 240 


Val Asn Leu Pro His Asp Lys Phe Val Ser Glu Asn Ser Glu Gln Gln 
                245                 250                 255     


Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu 
            260                 265                 270         


Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln His Phe Leu Pro Lys Leu 
        275                 280                 285             


Asp Asp Glu Gln Ile Asp Asn Val Leu Glu Asn Ser Val Pro Tyr Thr 
    290                 295                 300                 


Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn Ile Thr Lys Lys Val Arg 
305                 310                 315                 320 


Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu Lys Phe Ile Asp Gln Lys 
                325                 330                 335     


Lys Leu Phe Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val 
            340                 345                 350         


Leu Asp Glu Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Lys Arg Thr 
        355                 360                 365             


Val Thr Glu Asn Thr Lys Ala Phe Gly Met Leu Gln Asp Leu Asn Asp 
    370                 375                 380                 


Glu Glu Asn Val Leu Asn Lys Ile Asn Thr Gly Glu Ser Lys Ala Lys 
385                 390                 395                 400 


Phe Asp Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Thr Lys Asn 
            420                 425                 430         


Thr Asp Asn Lys Ile Lys Ser Asn Leu Leu Gln Pro Leu Pro Glu Ala 
        435                 440                 445             


Phe Leu Ser Ile Asn Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
    450                 455                 460                 


Glu Gln Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn 
465                 470                 475                 480 


Asn Ser Lys Ile Leu Asn Lys Glu Phe Ile Lys Ala Ile Lys Leu Lys 
                485                 490                 495     


Leu Asn Asp Leu Asp Val Phe Tyr Lys Arg Ser Gln Gly Arg Lys Gln 
            500                 505                 510         


Lys His Ala Tyr Leu Thr Lys Asp Lys Lys Tyr Asp Asn Glu Lys Ile 
        515                 520                 525             


Asn Glu Leu Lys Asn Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu 
    530                 535                 540                 


Tyr Asn Leu Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp 
545                 550                 555                 560 


Leu Asn Ile Ala Asp Val Gln Ala Lys Asn Ala Ile Ser Asp Arg Ile 
                565                 570                 575     


Lys Leu Met Lys Arg Asp Cys Ile Asn Arg Leu Lys Ser Met Lys Lys 
            580                 585                 590         


Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp 
        595                 600                 605             


Ile Val Asp Met Ile Ile Asp Glu Glu Lys Lys Lys Lys Ile Thr Ser 
    610                 615                 620                 


Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Lys 
625                 630                 635                 640 


Glu Lys Lys Glu Leu Phe Ile Leu Ile Cys Asn Asn Glu Leu Lys Leu 
                645                 650                 655     


Asn Asp Asp Asp Gly His Pro Phe Phe Lys Asn Ile Asn Phe Ser Asn 
            660                 665                 670         


Tyr Lys Tyr Thr Ser Glu Ile Tyr Gln Lys Tyr Leu Glu Glu Lys Gly 
        675                 680                 685             


His Lys Met Val Lys Glu Tyr Asn Pro Arg Lys Glu Asn Tyr Val Glu 
    690                 695                 700                 


Lys Asp Lys Ser Trp Leu Glu Ile Asn Phe Tyr Lys Lys Glu Trp Asn 
705                 710                 715                 720 


Glu Asn Ala Lys Lys Asp Leu Thr Val Val Lys Leu Pro Asp Asp Lys 
                725                 730                 735     


Ser Lys Ile Pro Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser 
            740                 745                 750         


Phe Glu Asn Trp Phe Lys Tyr Val Thr Asn Gly Lys Glu Thr Thr Asp 
        755                 760                 765             


Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp Glu Thr Leu 
    770                 775                 780                 


Lys Glu Leu Phe Lys Lys Glu Leu Ser Lys Asn Asn Ile Glu Phe Lys 
785                 790                 795                 800 


Glu Glu Asp Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Asp Lys Cys 
                805                 810                 815     


Arg Asn Asp Lys Thr Gln Lys Phe Tyr Ser Ala Glu Arg Glu Tyr Thr 
            820                 825                 830         


Phe Glu Glu Glu Lys Leu Asn Phe His Ile Asn Thr Lys Ser Lys Phe 
        835                 840                 845             


Glu Glu Tyr Ile Asn Pro Glu Phe Ala Glu Lys Val Phe Arg Leu Lys 
    850                 855                 860                 


Asn Gln Asn Arg Glu Lys Asp Asn Ile Ser Gly Arg Arg Leu Pro Pro 
865                 870                 875                 880 


Leu Lys Met Lys Glu Val Thr Lys Asn Met Val Lys Arg Ile Gly Asn 
                885                 890                 895     


Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Leu Met Leu 
            900                 905                 910         


Leu Met Phe Glu Lys Leu Val Asp Asn Asn Leu Lys Leu Lys Leu Glu 
        915                 920                 925             


Asn Val Asp Lys Leu Leu Asn Glu Ser Ile Glu Ile Asn Gln Ser Ile 
    930                 935                 940                 


Ser Gly Lys Leu Ser Phe Asp Asp Ser Gly Asp Asn Glu Asn Lys Lys 
945                 950                 955                 960 


Asp Arg Ala Ile Ile Cys Arg Asn Ile Thr Glu Thr Arg Lys Arg Lys 
                965                 970                 975     


Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Glu Glu Glu  Asn Ile Pro Ile Glu  Lys Ile Lys 
        995                 1000                 1005             


Ile Glu  Leu Asp Thr Tyr Ser  Lys Ala Lys Asp Val  Val Phe Asp 
    1010                 1015                 1020             


Leu Ile  Phe Asp Leu Glu Arg  Ala Ile Ile Asn Lys  Asp Glu Asn 
    1025                 1030                 1035             


Arg Ile  Lys Glu Leu Asn Lys  Asp Lys Asn Gly Val  Ile Gln Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Phe Trp Leu  Leu Glu Lys 
    1055                 1060                 1065             


Asn Leu  Ile Thr Glu Gln Glu  Phe Thr Phe Met Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Ile  Phe Ser His Asn Gln  Phe Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Leu Phe  Ile Lys Asn Trp Asn  Glu Asn Glu Phe Ala  Lys Gln Ile 
    1100                 1105                 1110             


Leu Asn  Val Tyr Asn Gln Lys  Asn Asn Asn Leu Ile  Lys Ser Ile 
    1115                 1120                 1125             


Lys Asp  Ile 
    1130     


<210>  2685
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2685

Met Asn Thr His Gln Glu Glu Leu Gln Ser Trp Ile Thr Arg Lys Arg 
1               5                   10                  15      


Leu Pro Asp Thr Glu Met Lys Lys Tyr Trp Ala Ala Tyr Met Asn Leu 
            20                  25                  30          


Ala Arg Leu Asn Phe Phe Lys Thr Leu Met Phe Ile Ser Asn Ser Ile 
        35                  40                  45              


Gly Asp Leu Lys Pro Ala Lys Asp Asn Asn Gly Lys Gly Asn Thr Glu 
    50                  55                  60                  


Val Asn Met His Asn Met Gly Ile Leu Thr Ala Leu Leu Gly Pro Glu 
65                  70                  75                  80  


Asp Glu Glu Lys Ala Arg Leu Leu Ile Phe Lys His Phe Pro Phe Leu 
                85                  90                  95      


Arg Thr Phe Cys Ile Glu Lys Glu Leu Ser Leu Ser Lys Gln Arg Thr 
            100                 105                 110         


Ile Leu Ile Asp Met Ala Cys Ile Ile Gly Arg Tyr Arg Asn Met Tyr 
        115                 120                 125             


Ser His Ser Ile Phe Ile Ser Asp Asp Asn Glu Lys Val Leu Glu Ser 
    130                 135                 140                 


Glu Lys Arg Cys Ser Glu Tyr Leu Gln Ser Ile Leu Thr Val Ser Thr 
145                 150                 155                 160 


Arg Ile Ile Lys Glu Arg Tyr Arg Ser Asn Lys Asn Asp Ala Gln Arg 
                165                 170                 175     


Gly Met Ile Asp Asp Lys Ser Leu Lys Phe Ile Ser Glu Asn Lys Val 
            180                 185                 190         


Lys Phe Val Tyr Asp Glu Asn Gly Lys Arg Ile Thr Ala Pro Asn Lys 
        195                 200                 205             


Lys Tyr Tyr Leu Ser Thr Ile Asp Lys Asp Asn Thr His Leu Ser Tyr 
    210                 215                 220                 


Phe Gly Lys Leu Met Leu Thr Cys Ile Leu Leu Glu Lys Lys Tyr Ala 
225                 230                 235                 240 


Thr Asp Phe Leu Thr Gln Cys His Phe Leu Asp Ala Phe Asn Asp Ser 
                245                 250                 255     


Glu Val Ala Pro Lys Leu Ser Glu Arg Arg Leu Met Leu Glu Val Met 
            260                 265                 270         


Thr Ala Leu Arg Ile Arg Leu Ala Glu Lys Lys Leu Ser Asn Glu Lys 
        275                 280                 285             


Ser Glu Val Gln Ile Ser Leu Asp Ile Leu Asn Glu Leu Lys Lys Cys 
    290                 295                 300                 


Pro Phe Glu Leu Tyr Glu Leu Leu Gly Ser Glu Asp Lys Arg Leu Phe 
305                 310                 315                 320 


Thr Ile Val Ala Asp Thr Gly Glu Thr Ile Leu Leu Arg Arg His Glu 
                325                 330                 335     


Asp Arg Phe Pro Gln Leu Ala Leu Ser Trp Ile Asp Ser Ser Lys Ala 
            340                 345                 350         


Phe Asp His Leu Arg Phe Gln Val Asn Ala Gly Lys Leu Arg Tyr Leu 
        355                 360                 365             


Phe Arg Asp Asn Lys His Cys Ile Asp Gly Gln Thr Arg Met Arg Val 
    370                 375                 380                 


Leu Glu Glu Pro Leu Asn Gly Tyr Arg Arg Leu Met Glu Phe Glu Glu 
385                 390                 395                 400 


Glu Arg Ile Gln Lys Gln Ser Gly Glu Ile Arg Ser Leu Trp Pro Gly 
                405                 410                 415     


Leu Asp Ile Leu Asn Lys Asp Glu Thr Pro Arg Asn Asp Ala Ser Val 
            420                 425                 430         


Leu Pro Tyr Ile Ser Asp Tyr Arg Val Arg Tyr Leu Phe Asp Gly Asp 
        435                 440                 445             


Asn Ile Gly Ile Ser Ile Gly Asp Phe Thr Pro Ser Ile Thr Lys Thr 
    450                 455                 460                 


Asp Glu Thr Lys Tyr Arg Val Thr Arg Lys Thr Ala Asp Cys Cys Leu 
465                 470                 475                 480 


Ser Lys Tyr Glu Leu Leu Gly Leu Leu Phe Tyr His Leu Leu Thr Leu 
                485                 490                 495     


Arg His Gly Asp Asn Lys Arg Ser Thr Lys Asn Ala Glu Asp Ile Ile 
            500                 505                 510         


Ile Asp Ala Ile Lys Arg Tyr Lys Arg Leu Phe Ser Asp Val Lys Glu 
        515                 520                 525             


Gly Ile Leu Lys Pro Ile Lys Glu Glu Asn Ala Asn Gln Leu Gly Asn 
    530                 535                 540                 


Arg Ile Trp Asn Ser Tyr Gly Ile Asn Ile Lys Asp Ile Pro Asp Lys 
545                 550                 555                 560 


Ile Ile Asp Tyr Leu Leu Val Arg Glu Cys Asn Glu Asp Glu Lys Phe 
                565                 570                 575     


Thr Ala Trp Lys Asn Gly Phe Ile Ser Glu Met Leu Gln Ser Thr Lys 
            580                 585                 590         


Asn Arg Ile Lys Arg Phe Glu Lys Asp Ser Glu Ala Val Ile Ser Ser 
        595                 600                 605             


Asp Asn Lys Pro Gly Lys Lys Asn His Val Ser Leu Lys Pro Gly Ala 
    610                 615                 620                 


Tyr Ala Ser Phe Ile Ala Asn Asp Ile Val Phe Phe Gln Glu Cys Gly 
625                 630                 635                 640 


Ala Thr Glu Lys Met Thr Gly Leu Asn Phe Lys Val Met Gln Ser Arg 
                645                 650                 655     


Leu Ala Thr Phe Thr Lys Asp Gly Ser Thr Ser Phe Asn Ile Leu Leu 
            660                 665                 670         


Gln Thr Leu Lys Asn Ala His Leu Val Ser Thr Thr Tyr Gly Lys Gly 
        675                 680                 685             


Asp His Pro Phe Leu Tyr Arg Val Ile Lys Gln Gln Pro Ser Asp Ile 
    690                 695                 700                 


Val Gln Phe Tyr Lys Ile Tyr Leu Asn Glu Lys Val Leu Tyr Leu Gln 
705                 710                 715                 720 


Ser Asp Ile Pro Asp Asn Ala Ile Phe Leu His Gly Glu Arg Lys Arg 
                725                 730                 735     


Trp Glu Asn Arg Asn Glu Gln Tyr Tyr Arg Asp Leu Ala Glu Arg Tyr 
            740                 745                 750         


Leu Gln Arg Pro Ile Gln Leu Pro Arg Gln Leu Phe Glu Ser His Ile 
        755                 760                 765             


Arg Gln Leu Leu Leu Ser Asp Cys Ile Lys Gly Glu Arg Gly Asn Asp 
    770                 775                 780                 


Leu Lys Glu Ala Ile Asn Ser Ala Ala Ser Gln Gly Arg Cys Asn Thr 
785                 790                 795                 800 


Thr Tyr Met Ile Met Glu Tyr Phe Ala Asp Tyr Leu Cys Asp Gly Thr 
                805                 810                 815     


Gln Phe Phe Tyr Gly Leu Phe Asp Gly Asp Leu Ser His Glu Tyr Asn 
            820                 825                 830         


Tyr Arg Phe Tyr Ser Leu Ile Ser Asn Asn Ile Glu Asn Ser Lys Lys 
        835                 840                 845             


Leu Val Leu Thr Leu Lys Lys Gly Asn Asn Ser Lys Glu Ser Pro Phe 
    850                 855                 860                 


Ile Ser Ala Leu Glu Arg Gly Ile His Trp Ser Lys Met Asn Pro Leu 
865                 870                 875                 880 


Met Lys Lys Gly Leu Lys Asn Asp Ser Ser Glu Gly Asp Phe Val His 
                885                 890                 895     


Ala Ala Lys Arg Ala Tyr Lys Glu Met Thr Glu Thr Glu Arg Met Phe 
            900                 905                 910         


Arg Arg Tyr Ala Val Gln Asp Glu Val Leu Phe Leu Ala Ala Lys Ile 
        915                 920                 925             


Thr Ile Arg Arg Ala Leu Gly Leu Ser Glu Gln Tyr Asn Cys Leu Leu 
    930                 935                 940                 


Gly Asp Ile Lys Pro Gln Gly Gly Ser Leu Leu Glu Gln Thr Ile Pro 
945                 950                 955                 960 


Ser Ile Thr Thr Lys His Thr Ile Asn Thr Gly Asn Lys Lys Gln Lys 
                965                 970                 975     


Pro Lys Gln Val Gln Ile Leu Gln Lys Asn Val Lys Leu Lys Asp Phe 
            980                 985                 990         


Gly Lys Val Phe Lys Leu Leu Asn  Asp Arg Arg Ile Phe  Asp Leu Leu 
        995                 1000                 1005             


Phe Asn  Lys Gly Asn Glu Ala  Val Ser Met Thr Asp  Leu Cys Glu 
    1010                 1015                 1020             


Glu Leu  Glu Arg Tyr Asp Arg  His Arg Val Asp Val  Phe Asp Ser 
    1025                 1030                 1035             


Val Leu  Lys Tyr Glu Ser Lys  Ile Thr Lys Gly Tyr  Thr Asn Lys 
    1040                 1045                 1050             


Glu Leu  Met Asn Glu Ser Gly  Gln Ile Asp Phe Lys  Ala Ile Gln 
    1055                 1060                 1065             


Ala Phe  Asp Lys Gln Asn Thr  Thr Ala Asp Lys Glu  Asp Leu Arg 
    1070                 1075                 1080             


Leu Ile  Arg Asn Ala Phe Ser  His Asn Gln Tyr Pro  Gln Tyr Asn 
    1085                 1090                 1095             


Asn Glu  Pro Ile Leu Phe Asp  Lys Asp Ile Pro Glu  Ile Ala Asp 
    1100                 1105                 1110             


Glu Ile  Ser Ile Ile Ala Lys  Asp Ile Glu Glu Asn  Thr Lys 
    1115                 1120                 1125         


<210>  2686
<211>  1091
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2686

Met Arg Ile Pro Ser Leu Ile Glu Asn Asn Lys Lys Tyr Tyr Ala Ile 
1               5                   10                  15      


His Ser Glu Met Ala Leu Leu Asn Ala Gln Ala Val Leu Asp His Ile 
            20                  25                  30          


Gln Lys Met Ala Gly Ile Glu Ala Tyr Ala Tyr Asn Glu Asn Glu Lys 
        35                  40                  45              


Lys Pro Ser Asp Glu Asp Leu Trp Val His Pro Val Met Ile Phe Leu 
    50                  55                  60                  


Asp Lys Ala Lys Thr Ser Glu Val Lys Ala Glu Lys Val Gln Tyr Val 
65                  70                  75                  80  


Ile Glu Arg Leu Cys Ser Tyr Phe Pro Phe Met Asn Ile Met Ala Gln 
                85                  90                  95      


Phe Gln Arg Glu Tyr Asp Asn Glu His Asn Lys Thr Asn Arg Leu Glu 
            100                 105                 110         


Val Asn Ala Asn Asp Met Tyr Asp Ala Leu Asn Lys Ile Phe Arg Val 
        115                 120                 125             


Leu Lys Lys Tyr Arg Asp Tyr Ser Ala His Tyr Lys Phe Glu Asp Asn 
    130                 135                 140                 


Cys Phe Ile Asp Gly Cys Ala Phe Leu Arg Tyr Ser Glu Gln Pro Leu 
145                 150                 155                 160 


Ala Ser Met Val Arg Lys Tyr Tyr Asp Val Ala Leu Arg Asn Ile Lys 
                165                 170                 175     


Glu Lys Tyr Asn Tyr Lys Thr Glu Glu Leu Ala Phe Ile Gln Asn Lys 
            180                 185                 190         


Arg Tyr Lys Met Thr Lys Gly Ile Asp Gly Arg Lys Lys Thr Val Gly 
        195                 200                 205             


Asn Pro Asn Phe Phe Leu Thr Leu Thr Ser Asn Asn Gly Asp Thr Thr 
    210                 215                 220                 


Asn Lys Trp His Leu Ser Gly Val Gly Val Ala Leu Leu Ile Ser Leu 
225                 230                 235                 240 


Phe Leu Asp Lys Gln Tyr Val Asn Leu Phe Trp Thr Arg Leu Pro Ile 
                245                 250                 255     


Phe Ser Asp Asn Arg Leu Lys Glu Glu Glu Arg Arg Val Ile Ile Arg 
            260                 265                 270         


Ser Met Gly Ile Asn Ser Val Lys Leu Pro Lys Asp Arg Ile His Met 
        275                 280                 285             


Asp Lys Asp Asp Met Ser Val Ala Met Asp Met Leu Asn Glu Leu Lys 
    290                 295                 300                 


Arg Cys Pro Asp Glu Leu Phe Asp Ile Leu Pro Ala Glu Lys Gln Ala 
305                 310                 315                 320 


His Phe Arg Ile Ile Ser Ser Asp His Asn Glu Val Leu Met Lys Arg 
                325                 330                 335     


Ser Thr Asp Arg Phe Thr Ser Met Leu Leu Gln Tyr Ile Asp Tyr Gly 
            340                 345                 350         


Lys Lys Phe Lys Gln Ile Arg Phe His Val Asn Met Gly Lys Leu Arg 
        355                 360                 365             


Tyr Leu Leu Asn Ala Glu Lys Asn Cys Ile Asp Gly Asn Ile Arg Thr 
    370                 375                 380                 


Arg Val Ile Glu His Pro Leu Asn Gly Tyr Gly Arg Ile Asp Glu Ile 
385                 390                 395                 400 


Glu Glu Leu Arg Lys Asn Glu Asp Met Thr Tyr Ala Asp Thr Gly Ile 
                405                 410                 415     


Arg Ile Lys Asp Phe Glu Ser Met Thr Arg Asp Asp Ser Asp Thr Ala 
            420                 425                 430         


Asn Tyr Pro Tyr Val Val Asp Thr Tyr Thr His Tyr Leu Leu Glu Asn 
        435                 440                 445             


Asn Lys Val Glu Phe Ser Phe Cys Gly Asn Ser Ser Leu Pro Glu Val 
    450                 455                 460                 


Ser Glu Arg Asn Gly Lys Trp Tyr Val Ser Lys Asp Val Pro Ala Cys 
465                 470                 475                 480 


Arg Met Ser Ile Leu Glu Leu Pro Ala Met Ala Phe His Met Leu Leu 
                485                 490                 495     


Leu Gly Ser Glu Lys Thr Glu Ala Arg Ile Lys Ser Val Tyr Asp Asn 
            500                 505                 510         


Tyr Cys Arg Leu Phe Glu Ala Met Arg Lys Gly Gln Val Ser Met Asp 
        515                 520                 525             


Asn Leu Ser Asp Phe Gly Ile Ala Gln Glu Asp Ile Pro Gln Arg Val 
    530                 535                 540                 


Met Asn Cys Ile Asn Gly Ser Gly Gln Gly Lys Asp Leu Val Gly Phe 
545                 550                 555                 560 


Ile Ser Arg Lys Leu Glu Ala Met Ser Glu Asp Thr Arg Tyr Arg Leu 
                565                 570                 575     


Glu Arg Leu Ser Glu Asp Arg Lys Ala Ile Gly Ser Arg Asp Asn Lys 
            580                 585                 590         


Met Gly Lys Arg Gly Tyr Arg Gln Ile Arg Thr Gly Val Phe Ala Asp 
        595                 600                 605             


Phe Leu Ala Lys Asp Ile Val Leu Leu Gln Leu Ala Gly Asn Asn Gly 
    610                 615                 620                 


Ala Asn Lys Met Thr Gly Leu Asn Tyr Arg Val Met Gln Ser Ser Ile 
625                 630                 635                 640 


Ala Thr Tyr Asp Ser His Gly Asp Ile Glu Thr Lys Lys Glu Phe Lys 
                645                 650                 655     


Ala Leu Phe Glu Arg Ala Asn Leu Leu Val Cys Asn Pro Lys Ser Gly 
            660                 665                 670         


His Pro Phe Leu Phe Lys Val Phe Ala Arg Ser Ile Pro Glu Asn Ala 
        675                 680                 685             


Ile Glu Phe Tyr Glu Arg Tyr Leu Tyr Glu Arg Gln Ala Tyr Leu Asp 
    690                 695                 700                 


Gly Leu Arg Ile Lys Ile Ala Lys Gly Lys Thr Pro Asp Val Pro Phe 
705                 710                 715                 720 


Val Asn Lys Asn Gln Met Lys Trp Lys Ser Pro Ala Gln Glu Asp Leu 
                725                 730                 735     


Ser Leu Ser Tyr Thr Asp Asn Leu Ala Ile Glu Leu Pro Arg Gln Met 
            740                 745                 750         


Phe Asp Ala Asp Ile Lys Asp Cys Leu Met Arg Met Asp Lys Met Lys 
        755                 760                 765             


Asp Val Asp Phe Ser Asn Ala Asn Val Thr Tyr Leu Ile Ala Glu Tyr 
    770                 775                 780                 


Met His Arg Val Leu Asn Asp Asp Phe Gln Pro Phe Tyr Gly Trp Glu 
785                 790                 795                 800 


Arg Asn Tyr Pro Phe Ile Asp Met Leu Arg Leu Lys Thr Asp Lys Lys 
                805                 810                 815     


Gly Ser Leu Cys Ala Ser Phe Thr Ser Val Asp Glu Arg Ala Glu Leu 
            820                 825                 830         


Trp Lys Arg Arg Asp Glu Leu Met Asp Ala Tyr Lys Gln Trp Val Val 
        835                 840                 845             


Arg Asn Ser Gly Arg Lys Gly Met Ser Arg Asp Glu Ala Glu Glu Cys 
    850                 855                 860                 


Ala Asp Arg Arg Leu Val Ser Ser Arg Asn Glu Tyr Gln Lys Thr Glu 
865                 870                 875                 880 


Lys Val Ile Arg Arg Tyr Lys Val Gln Asp Ala Leu Leu Phe Leu Met 
                885                 890                 895     


Ala Lys Asp Val Met Thr Lys Tyr Ala Glu Tyr Asp Gly Asp Met Phe 
            900                 905                 910         


Ser Leu Lys Glu Ile Met Pro Asn Ser Asp Lys Gly Ile Leu Ser Val 
        915                 920                 925             


Ile Met Pro Met Thr Phe Thr Phe Glu Lys Asn Gly Glu Lys Ile Thr 
    930                 935                 940                 


Ile Lys Ser Ser Gly Met Lys Leu Lys Asn Phe Gly Asp Phe Phe Pro 
945                 950                 955                 960 


Leu Ala Asn Asp Arg Arg Leu Ile Asn Leu Ser Arg Leu Ile Gly Thr 
                965                 970                 975     


Asn Thr Ile Ser Lys Glu Asp Leu Glu Glu Glu Phe Lys Asn Tyr Asp 
            980                 985                 990         


Gln Cys Arg Pro Glu Met Ala Ser  Leu Ile Leu Asp Ile  Glu Lys Tyr 
        995                 1000                 1005             


Ala Phe  Asp Met Tyr Pro Gln  Leu Glu Lys Lys Leu  Asn Ser Thr 
    1010                 1015                 1020             


Asn His  Lys Val Tyr Phe Lys  Asp Ile Leu Gln Ala  Leu Lys Gln 
    1025                 1030                 1035             


Asp Ser  Lys Val Asp Asp Ala  Lys Gly Asn Val Leu  Gly Leu Ile 
    1040                 1045                 1050             


Arg Asn  Ala Phe Glu His Asn  Asn Tyr Pro Asp Lys  Gly Val Val 
    1055                 1060                 1065             


Glu Ile  Ser Thr Leu Pro Glu  Val Ala Arg Glu Leu  Lys Ala Val 
    1070                 1075                 1080             


Phe Glu  Lys Tyr Thr Ile Cys  Lys 
    1085                 1090     


<210>  2687
<211>  1085
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2687

Met Lys Lys Glu Leu Asn Arg Glu Asp Val Phe Thr Gly Gly Lys Thr 
1               5                   10                  15      


Pro Glu Leu Thr Ile Tyr Tyr Asn Ile Ala Tyr Phe Arg Met Ala Gly 
            20                  25                  30          


Leu Ile Asn Ala Leu Cys Gly Asn Lys Leu Glu Arg Asp Lys Asp Ala 
        35                  40                  45              


Leu Glu Gln Phe Met Lys Ala Phe Ile Asn Gly Lys Gln Lys Leu Thr 
    50                  55                  60                  


Asp Met Gln Phe Val Lys Leu Cys Asp Tyr Leu Trp Lys Gly Tyr Lys 
65                  70                  75                  80  


Tyr Asp Lys Asn Arg Ser Glu Tyr Ser Leu Thr Glu Asn Asp Lys Thr 
                85                  90                  95      


Met Val Leu Lys Met Val Ala Lys Leu Gln Asp Ile Arg Asn Phe Gln 
            100                 105                 110         


Ser His Ile Trp His Asp Asn Lys Val Leu Val Phe Asp Ala Asp Leu 
        115                 120                 125             


Val Gln Phe Ile Lys Asn Lys His Leu Glu Ala Ile Asp Ala Gln Arg 
    130                 135                 140                 


Gln Arg Phe Ser Lys Glu Thr Glu Val Tyr Glu Lys Glu Asn Arg Glu 
145                 150                 155                 160 


Leu Lys Lys Lys Lys Asn Lys Glu Leu Leu Phe Asp Ile His Asp Gly 
                165                 170                 175     


Leu Gly Tyr Ile Thr Gly Glu Gly Arg Asn Phe Phe Leu Ser Phe Phe 
            180                 185                 190         


Leu Thr Arg Gly Glu Met Thr Arg Phe Leu Lys Gln Arg Lys Gly Cys 
        195                 200                 205             


Lys Arg Asp Asp Thr Pro Glu Tyr Lys Ile Lys His Leu Val Tyr Arg 
    210                 215                 220                 


His Phe Thr His Arg Asp Gly Ala Thr Arg Thr His Tyr Gly Tyr Glu 
225                 230                 235                 240 


Asp Asn Met Leu Asp Gln Leu Pro Asp Lys Gln Glu Phe Leu Thr Thr 
                245                 250                 255     


Arg His Thr Tyr Arg Leu Ile Asn Tyr Leu Asn Asp Ile Pro Glu Glu 
            260                 265                 270         


Val Thr Asn Pro Glu Leu Phe Pro Leu Phe Asn Thr Ile Ser Asn Gly 
        275                 280                 285             


Ile Leu Ile Lys Glu Ser Val Gly Thr Tyr Ile Ala Phe Ile Asn Lys 
    290                 295                 300                 


Met Pro Leu Leu Ser Asp Phe Glu Phe Ser Glu Val Trp Gly Lys Asp 
305                 310                 315                 320 


Gly Lys Pro Tyr Thr Asn Leu Val Glu Phe Tyr His Lys Thr Gln Pro 
                325                 330                 335     


Gly Phe Lys Phe Arg Thr Asp Leu Asn Ser Phe His Lys Ile Ile Leu 
            340                 345                 350         


Asn Leu Ile Arg Asp Glu Asn Tyr Thr Gly Phe Phe Thr Thr Gln Leu 
        355                 360                 365             


Asn Leu Phe Met Ala His Arg Glu Glu Leu Ile Leu Val Ile Ser Lys 
    370                 375                 380                 


Pro Leu Ile Thr Pro Asn Asp Leu Leu Leu Ile Glu Glu His Tyr Arg 
385                 390                 395                 400 


Tyr Lys Leu Lys Ala Asn Asp Phe Val Arg Glu Lys Leu Gly Glu Trp 
                405                 410                 415     


Lys Glu Lys Ile Glu Lys Gly Lys Trp Glu Lys Ala Asn Glu Gln Lys 
            420                 425                 430         


Asp Lys Leu Ile Asn Leu Leu Gly Gly Val Ile Glu Ile Thr Phe Tyr 
        435                 440                 445             


Asp Phe Tyr Trp Gln Lys Asp Glu Lys Pro Arg Asn Glu Asn Arg Phe 
    450                 455                 460                 


Met Glu Phe Ala Ile Arg Phe Met Ala Asp Phe Asn Leu Leu Pro Asp 
465                 470                 475                 480 


Cys Glu Trp Glu Val Glu Pro Leu Gln Ile Glu Asn Asp Leu Ile Ala 
                485                 490                 495     


Asn Arg Thr Ala Thr Pro Asp Leu Lys Lys Ser Gly Ser Gln Phe Met 
            500                 505                 510         


Asn Gln Leu Thr Asp Asn Tyr Arg Leu Lys Phe Asn Asp Gly Gln Ile 
        515                 520                 525             


Ala Phe Arg Tyr Gln Asn Gln Val Phe Ile Met Gly His Lys Ala Val 
    530                 535                 540                 


Lys Asn Leu Leu Ile Ala Cys Phe Asp Gly Lys Glu Lys Met Leu Asn 
545                 550                 555                 560 


Gly Phe Met Pro Ala Leu Leu Ala Asp Leu Lys Lys Ile Thr Asn Glu 
                565                 570                 575     


His Ile Leu Lys Asn His Gln Ala Leu Asn Thr Leu Ser Leu Leu Asn 
            580                 585                 590         


Asn Asp Ser Ile Pro Ser Tyr Ile Ser Arg Gln Trp Gly Glu Ala Glu 
        595                 600                 605             


Pro Ile Thr Asp Met Lys Lys Lys Ala Ile Ala Arg Met Asp Tyr Ile 
    610                 615                 620                 


Thr Gln Gln Phe Glu Ala Leu Ile Glu Asn His His Tyr Leu Asn Arg 
625                 630                 635                 640 


Ala Asp Lys Asn Arg Gln Ile Met Arg Cys Tyr Lys Phe Phe Glu Trp 
                645                 650                 655     


Gln Tyr Pro Gln Asn Ser Gln Phe Lys Phe Leu Arg Arg Asn Glu Tyr 
            660                 665                 670         


His Arg Met Ser Ile Tyr His Tyr Cys Leu Asp Lys Glu Gln His Lys 
        675                 680                 685             


Tyr Asp Lys Lys Gly His Asn Tyr Leu Tyr Asn Arg Leu Ile Lys Glu 
    690                 695                 700                 


Ser His Asn Glu Ser Gly Asn Ile Glu Gln His Leu Pro Tyr Gln Ile 
705                 710                 715                 720 


Arg Thr Met Leu Asn Asp Ala Lys Asp Phe Asn Asp Tyr Phe Leu Arg 
                725                 730                 735     


Ile Leu Asn Ala Thr His Lys Ile Leu Thr Asp Trp Lys Asn Gln Leu 
            740                 745                 750         


Lys Gln Gly Arg Glu Pro Asn Asn Tyr Tyr Leu Ser Arg Leu Gly Phe 
        755                 760                 765             


Thr Gly Gly Leu Thr Gln Lys Val Val His Thr Arg Leu Leu Pro Phe 
    770                 775                 780                 


Ser Ile His Pro Gly Ile Pro Val Ser Phe Phe Tyr Arg Thr Glu Met 
785                 790                 795                 800 


Asn Gln Asn Pro Ser Phe Asn Leu Ser Ala Lys Val Trp Asn Ser Glu 
                805                 810                 815     


Ser Pro Phe Arg Val Gly Leu Lys Glu Ser Asn Tyr Gln Tyr Ala Lys 
            820                 825                 830         


Tyr Leu Gly Leu Phe Asn Glu Ile Lys Thr Gln Arg Lys Ile Ile Gly 
        835                 840                 845             


Lys Met Asn Gln Leu Ile Ala Glu Asp Ala Leu Leu Trp Gln Ile Ala 
    850                 855                 860                 


Lys Lys Tyr Leu Asp Lys Cys His Pro Lys Phe Ser Glu Ile Ile Asn 
865                 870                 875                 880 


Gln Gln Val Asn Gly Lys Gln Pro Leu Asn Val Lys Ala Ile His Asp 
                885                 890                 895     


Thr Glu Leu Thr Ile Asp Phe Pro Val Asp Lys Asn Leu Tyr Gln Val 
            900                 905                 910         


Val Val Lys Met Lys Gln Leu Asp Asp Phe Met Phe Ile Asp Ser Lys 
        915                 920                 925             


Pro Val Leu Glu Lys Thr Ile Arg Tyr Met Ile Lys Asn Ser Leu Arg 
    930                 935                 940                 


Asp Lys Glu Tyr Gln Gln Arg Val Phe Ile Glu Thr Asn Pro Gly Val 
945                 950                 955                 960 


Phe Lys Ile Pro Tyr Asn Glu Val Val Glu Ala Met Arg Thr Ile Asn 
                965                 970                 975     


His Gln Ala Leu Thr Trp Ala Arg Leu Leu Leu Asp Trp Glu Ser Lys 
            980                 985                 990         


Thr Val Lys Thr Ile Pro Glu Ala  Asp Lys Lys Ala Lys  Leu Gln Glu 
        995                 1000                 1005             


Ala Tyr  Asn Lys Arg Gln Pro  Ala Phe Phe Asn Phe  Asn Asp Ile 
    1010                 1015                 1020             


Cys Arg  Tyr Ala Asp Asp Gly  Lys Gln Leu Lys Asp  Leu Arg Asn 
    1025                 1030                 1035             


Lys Thr  Phe His Thr Glu Val  Pro Glu Thr Trp Thr  Tyr Asp Glu 
    1040                 1045                 1050             


Met Arg  Glu Asn Lys Thr Ile  Lys Met Val Leu Gly  Ile Asn Glu 
    1055                 1060                 1065             


Thr Thr  Phe Leu Lys Lys Asp  Tyr Ala Ile Glu Asn  Ala Arg Thr 
    1070                 1075                 1080             


Ile Glu  
    1085 


<210>  2688
<211>  1081
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2688

Met Lys Lys Thr Asn Thr Tyr Phe Asp Phe Lys Asp Lys Thr Gln Lys 
1               5                   10                  15      


Tyr Phe Phe Ala Gly Leu Phe Asn Thr Ala Leu Asn Asn Phe Asp Leu 
            20                  25                  30          


Ser Leu Asp Glu Leu Ala Asn Arg Thr Gly Leu Lys Cys Asn Gly Lys 
        35                  40                  45              


Glu Leu Ile Ala Val Ala Phe Asn Asp Thr Cys Ser Gln Thr Asp Tyr 
    50                  55                  60                  


Asn Asn Arg Leu Ser Tyr Leu Ser Glu Ser Leu Ala Phe Ile Glu Leu 
65                  70                  75                  80  


Ile Lys Thr Lys Glu Arg Ser Tyr Ile Arg Leu His Leu Thr Glu Leu 
                85                  90                  95      


Tyr Asn Leu Ile Asp Asn Tyr Arg Asn Tyr Phe Thr His Leu Glu His 
            100                 105                 110         


Pro Gly Leu Ile Ile Lys Pro Leu Ile Phe Lys Leu Leu Asp Leu Phe 
        115                 120                 125             


Ile Leu Glu Ser Ala Arg Thr Val Ile Lys Glu Arg Val Lys Thr Glu 
    130                 135                 140                 


Glu Asn Lys Ser Tyr Leu Ser Lys Lys Phe Lys Leu Glu Ile Thr Ser 
145                 150                 155                 160 


Thr Phe Glu Ala Ala Asn Asn Ala Ile Asn Leu Glu Asn Lys Asn Asn 
                165                 170                 175     


Pro His Ser Lys Thr His Lys Lys Leu Ile Thr Gln Asn Asp Lys Ile 
            180                 185                 190         


Asn Phe Val Leu Asn Lys Ala Phe His Asn Phe Leu Ile Asn Thr Asp 
        195                 200                 205             


Gly Val Pro Thr Leu Lys Glu Thr Ala Arg Ser Ile Asn Lys Asp Thr 
    210                 215                 220                 


Gly Gln Ile Ser Gln Asn Gly Ile Ile Gln Leu Leu Ala Ile Phe Leu 
225                 230                 235                 240 


Asn Lys Lys Gln Leu Glu Ile Leu Phe Asp Asn Thr His Tyr Leu Lys 
                245                 250                 255     


Gly Thr Leu Lys Leu Asn His Leu Cys Thr Arg Trp Thr Tyr Ser Gln 
            260                 265                 270         


Leu Ala Tyr Arg Asn Ile Lys Lys Leu Leu Lys Ser Asp Tyr Ser Asn 
        275                 280                 285             


Asp Ser Leu Ile Leu Gln Met Leu Ser Glu Leu Thr Lys Cys Pro Lys 
    290                 295                 300                 


His Leu Tyr Pro Asn Leu Pro Asn Asn Ser Lys Gln Glu Phe Ile Glu 
305                 310                 315                 320 


Asp Leu Asn Glu Tyr Leu Lys Glu Thr Glu Tyr Phe Lys Asp Ser Ile 
                325                 330                 335     


Ala Gln Glu Thr Val Ser Asn Glu Val Ile Arg Lys Arg Tyr Glu Asp 
            340                 345                 350         


Lys Phe Pro Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe Ile Asp Phe 
        355                 360                 365             


Pro Asn Leu Arg Phe Gln Ile Asn Leu Gly Lys Phe Asn His Asn Thr 
    370                 375                 380                 


Cys Leu Lys Lys Phe Glu Asn Thr Ala Val Tyr Thr Glu Arg Gln Ile 
385                 390                 395                 400 


Leu Glu Lys Leu Thr Ile Phe Glu Lys Leu Thr Leu Ala Thr Asn Lys 
                405                 410                 415     


Lys Thr Glu Tyr Phe Leu Asn Asn Asn Leu Pro Asp Ser Glu Gly Trp 
            420                 425                 430         


Gln Glu Tyr Pro Lys Pro Ser Tyr Gln Phe Tyr Asn Asn Asn Ile Gly 
        435                 440                 445             


Phe Trp Leu Gly Ile Lys Asn Gly Ala Val Thr Asp Ala Lys Glu Lys 
    450                 455                 460                 


Arg Glu Asn Asp Lys Ser Ser Lys Phe Asp Ile Leu Lys Lys Ile Gly 
465                 470                 475                 480 


Leu Glu Cys Cys Leu Lys Lys Pro Val Ala Tyr Leu Ser Phe Asn Glu 
                485                 490                 495     


Leu Pro Ala Leu Leu Tyr Thr Val Leu Ile Glu Lys Lys Thr Ala Lys 
            500                 505                 510         


Glu Val Glu Arg Ile Phe Leu Lys Lys Ile Gly Glu Gln Thr Gly Ala 
        515                 520                 525             


Ile Asn Lys Phe Ala Asp Ile Asn Asn Phe Glu Lys Lys Ile Ile Pro 
    530                 535                 540                 


His Lys Phe Lys Glu Ile Leu Glu Asn Lys Glu Ser Asn Val Lys Trp 
545                 550                 555                 560 


Glu Lys Leu Lys Lys Asp Ile Glu Lys Glu Met Leu Ile Ser Pro Leu 
                565                 570                 575     


Asp Glu Ile Arg Ile His Tyr Lys Thr Ala Ser Lys His Pro Asn Asp 
            580                 585                 590         


Leu Ser Phe Ser Glu Lys Gly Lys Ile Ala Thr Trp Leu Ala His Asp 
        595                 600                 605             


Ile Lys Arg Phe Val Lys Ala Glu Thr Lys Lys Asp Trp Lys Gly Tyr 
    610                 615                 620                 


Gln Phe Ser Glu Phe Gln Ser Leu Leu Ala Tyr Tyr Asp Leu Lys Lys 
625                 630                 635                 640 


Met Glu Leu Leu Asn Phe Val Asn Phe Val Leu Lys Ile Asn Ile Lys 
                645                 650                 655     


Gln Asp Ile Val Phe Glu Asp Ile Asp Phe Asn Gln Lys Thr Leu Tyr 
            660                 665                 670         


Asp Phe Tyr Lys Asn Tyr Leu Ser Asn Arg Lys Lys Phe Leu Glu Gly 
        675                 680                 685             


Asn Leu Tyr Ser Ile Asp Gln Lys Asp Glu Val Pro Ala Lys Leu Trp 
    690                 695                 700                 


Arg Lys Arg Glu Leu Ser Ile Phe Thr Gly Phe Asp Asp Lys Leu Tyr 
705                 710                 715                 720 


Lys Tyr Lys Asn Phe Lys Thr Tyr Lys Glu Asn Leu Met Asn Met Pro 
                725                 730                 735     


Leu Asn Leu Pro Arg Gly Ile Phe Ser Asp Lys Gln Thr Cys Tyr Asn 
            740                 745                 750         


Lys Asn Ser Gln Asn Asn Asn Glu Leu Ala Glu Trp Phe Thr Lys Ser 
        755                 760                 765             


Asn Asn Ile Asn Asp Phe Gln Lys Phe Tyr Ser Phe Thr Arg Phe Tyr 
    770                 775                 780                 


Glu Asn Cys Gln Leu Thr Leu Asn Pro Leu Lys Gly Leu Lys Glu Gln 
785                 790                 795                 800 


Asn Asn Asn Lys Gly Val Pro Lys Glu Val Tyr Lys Asn Glu Lys Asn 
                805                 810                 815     


Ile Arg Asn Thr Met Arg Gln Asp Phe Tyr Ile Phe Glu Met Val Lys 
            820                 825                 830         


Tyr Tyr Phe Lys Ile Asn Glu Ser Leu Lys Ser Asp Leu Asn Asp Leu 
        835                 840                 845             


Lys Leu Asn Thr Leu Phe Leu Thr Lys Gln Glu Lys Glu Asn Asn Leu 
    850                 855                 860                 


Lys Val Leu Asn Gln Gln His Ser Arg Ser Lys Gly Asp Lys Ser Glu 
865                 870                 875                 880 


Asn Ile Leu Asn Glu Asn Tyr Ile Leu Ser Lys His Ile Met Met Ser 
                885                 890                 895     


Ile Leu Glu Gly Lys Ile Gln Gly Met Val Ala Leu Lys Ser Val Gly 
            900                 905                 910         


Lys Tyr Arg Phe Leu Ser Gln Asp Lys Arg Val Lys Gln Leu Val Thr 
        915                 920                 925             


Tyr Ile Pro Asp Lys Ile Trp Ser Phe Glu Glu Ile Asn Ser Glu Ile 
    930                 935                 940                 


Asp Glu Tyr Asp Lys Ile Arg Ala Phe Ser Phe Phe Lys Ile Ile His 
945                 950                 955                 960 


Glu Ile Glu Glu Lys Ile Phe Asn Lys Ala Ile Asn Asn Lys Glu Glu 
                965                 970                 975     


Ser Tyr Leu Leu Val Asp Gly His Pro Asn Phe Lys Ala Tyr Ile Ile 
            980                 985                 990         


Tyr Tyr Phe Leu Lys Thr Gln Asp  Glu Lys Asp Phe Phe  Asn Lys Leu 
        995                 1000                 1005             


Asp Val  Lys Asn Val Asn Ile  Asn Asp Ile Ala Ile  Ser Lys Phe 
    1010                 1015                 1020             


Lys Leu  Leu Phe Leu Ile Ile  Lys Ile Arg Asn Lys  Ile Cys His 
    1025                 1030                 1035             


Asn Gln  Leu Ile Ser Ser Asp  Glu Phe Asn Phe Leu  Leu Glu Phe 
    1040                 1045                 1050             


Thr Pro  Ile Glu Pro Asp Glu  Leu Tyr Met Ser Tyr  Leu Leu Lys 
    1055                 1060                 1065             


Ala Tyr  Lys Lys Ile Val Asn  Ile Ser Trp Asn Leu  Val 
    1070                 1075                 1080     


<210>  2689
<211>  1131
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2689

Met Glu Lys Thr Ile Glu Asn Gln Thr Gln Ser Lys Arg Thr Leu Asn 
1               5                   10                  15      


Asn Thr Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Asp Glu Glu Lys Ile Thr Thr Ser Phe Leu Val Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Arg Gln Ser Leu Val Tyr Ser Asn Leu Thr 
65                  70                  75                  80  


Arg Tyr Met His Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Asp 
                85                  90                  95      


Asp Glu Arg Asp Lys Ala Glu Asn Tyr Gly Lys Asp Phe Gly Asn Leu 
            100                 105                 110         


Thr Asp Thr Leu Lys Glu Ile Phe Lys Glu Leu Asn Glu Phe Arg Asn 
        115                 120                 125             


Asp Tyr Ser His Tyr Tyr Ser Thr Glu Lys Lys Asp Lys Arg Lys Thr 
    130                 135                 140                 


Ile Val Ser Asp Lys Leu Lys Asn Phe Leu Asn Ile Asn Tyr Thr Arg 
145                 150                 155                 160 


Ala Ile Lys Tyr Thr Lys Ser Arg Phe Ile Asn Val Phe Ser Asp Asn 
                165                 170                 175     


Asn Phe Cys Leu Ala Glu Glu Ala Lys His Val Glu Asn Asp Asn Thr 
            180                 185                 190         


Ile Thr Gln Asp Gly Ile Val Phe Phe Thr Ser Met Phe Leu Asp Arg 
        195                 200                 205             


Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile Ile Gly Leu Lys Gly Thr 
    210                 215                 220                 


Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Thr Leu Met Ala Phe Cys 
225                 230                 235                 240 


Val Asn Leu Pro His Asp Lys Phe Val Ser Glu Asn Ser Glu Gln Gln 
                245                 250                 255     


Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu 
            260                 265                 270         


Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln His Phe Leu Pro Lys Leu 
        275                 280                 285             


Asp Asp Glu Gln Ile Asp Asn Val Leu Glu Asn Ser Val Pro Tyr Thr 
    290                 295                 300                 


Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn Ile Thr Lys Lys Val Arg 
305                 310                 315                 320 


Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu Lys Phe Ile Asp Gln Lys 
                325                 330                 335     


Lys Leu Phe Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val 
            340                 345                 350         


Leu Asp Glu Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Lys Arg Thr 
        355                 360                 365             


Val Thr Glu Asn Thr Lys Ala Phe Gly Met Leu Gln Asp Leu Asn Asp 
    370                 375                 380                 


Glu Glu Asn Val Leu Asn Lys Ile Asn Thr Gly Glu Ser Lys Ala Lys 
385                 390                 395                 400 


Phe Asp Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Thr Lys Asn 
            420                 425                 430         


Thr Asp Asn Lys Ile Lys Ser Asn Leu Leu Gln Pro Leu Pro Glu Ala 
        435                 440                 445             


Phe Leu Ser Ile Asn Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
    450                 455                 460                 


Glu Gln Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn 
465                 470                 475                 480 


Asn Ser Lys Ile Leu Asn Lys Glu Phe Ile Lys Ala Ile Lys Leu Lys 
                485                 490                 495     


Leu Asn Asp Leu Asp Val Phe Tyr Lys Arg Ser Gln Gly Arg Lys Gln 
            500                 505                 510         


Lys His Ala Tyr Leu Thr Lys Asp Lys Lys Tyr Asp Asn Glu Lys Ile 
        515                 520                 525             


Asn Glu Leu Lys Asn Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu 
    530                 535                 540                 


Tyr Asn Leu Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp 
545                 550                 555                 560 


Leu Asn Ile Ala Asp Val Gln Ala Lys Asn Ala Ile Ser Asp Arg Ile 
                565                 570                 575     


Lys Leu Met Lys Arg Asp Cys Ile Asn Arg Leu Lys Ser Met Lys Lys 
            580                 585                 590         


Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp 
        595                 600                 605             


Ile Val Asp Met Ile Ile Asp Glu Glu Lys Lys Lys Lys Ile Thr Ser 
    610                 615                 620                 


Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Lys 
625                 630                 635                 640 


Glu Lys Lys Glu Leu Phe Ile Leu Ile Cys Asn Asn Glu Leu Lys Leu 
                645                 650                 655     


Asn Asp Asp Asp Gly His Pro Phe Phe Lys Asn Ile Asn Phe Ser Asn 
            660                 665                 670         


Tyr Lys Tyr Thr Ser Glu Ile Tyr Gln Lys Tyr Leu Glu Glu Lys Gly 
        675                 680                 685             


His Lys Met Val Lys Glu Tyr Asn Pro Arg Lys Glu Asn Tyr Val Glu 
    690                 695                 700                 


Lys Asp Lys Ser Trp Leu Glu Ile Asn Phe Tyr Lys Lys Glu Trp Asn 
705                 710                 715                 720 


Glu Asn Ala Lys Lys Asp Leu Thr Val Val Lys Leu Pro Asp Asp Lys 
                725                 730                 735     


Ser Lys Ile Pro Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser 
            740                 745                 750         


Phe Glu Asn Trp Phe Lys Tyr Val Thr Asn Gly Lys Glu Thr Thr Asp 
        755                 760                 765             


Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp Glu Thr Leu 
    770                 775                 780                 


Lys Glu Leu Leu Lys Lys Glu Leu Ser Lys Asn Asn Ile Glu Phe Lys 
785                 790                 795                 800 


Glu Glu Asp Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Asp Lys Cys 
                805                 810                 815     


Arg Asn Asp Lys Thr Gln Lys Phe Tyr Ser Ala Glu Arg Glu Tyr Thr 
            820                 825                 830         


Phe Glu Glu Glu Lys Leu Asn Phe His Ile Asn Thr Lys Ser Lys Phe 
        835                 840                 845             


Glu Glu Tyr Ile Asn Pro Glu Phe Ala Glu Lys Val Phe Arg Leu Lys 
    850                 855                 860                 


Asn Gln Asn Arg Glu Lys Asp Asn Ile Ser Gly Arg Arg Leu Pro Pro 
865                 870                 875                 880 


Leu Lys Met Lys Glu Val Thr Lys Asn Met Val Lys Arg Ile Gly Asn 
                885                 890                 895     


Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Leu Met Leu 
            900                 905                 910         


Leu Met Phe Glu Lys Leu Val Asp Asn Asn Leu Lys Leu Lys Leu Glu 
        915                 920                 925             


Asn Val Asp Lys Leu Leu Asn Glu Ser Ile Glu Ile Asn Gln Ser Ile 
    930                 935                 940                 


Ser Gly Lys Leu Ser Phe Asp Asp Ser Gly Asp Asn Glu Asn Lys Lys 
945                 950                 955                 960 


Asp Arg Ala Ile Ile Cys Arg Asn Ile Thr Glu Thr Arg Lys Arg Lys 
                965                 970                 975     


Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Glu Glu Glu  Asn Ile Pro Ile Glu  Lys Ile Lys 
        995                 1000                 1005             


Ile Glu  Leu Asp Thr Tyr Ser  Lys Ala Lys Asp Val  Val Phe Asp 
    1010                 1015                 1020             


Leu Ile  Phe Asp Leu Glu Arg  Ala Ile Ile Asn Lys  Asp Glu Asn 
    1025                 1030                 1035             


Arg Ile  Lys Glu Leu Asn Lys  Asp Lys Asn Gly Val  Ile Gln Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Phe Trp Leu  Leu Glu Lys 
    1055                 1060                 1065             


Asn Leu  Ile Thr Glu Gln Glu  Phe Thr Phe Met Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Thr  Phe Ser His Asn Gln  Phe Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Leu Phe  Ile Lys Asn Trp Asn  Glu Asn Glu Phe Ala  Lys Gln Ile 
    1100                 1105                 1110             


Leu Asn  Val Tyr Asn Gln Lys  Asn Asn Asn Leu Ile  Lys Ser Ile 
    1115                 1120                 1125             


Lys Asp  Ile 
    1130     


<210>  2690
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2690

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2691
<211>  1131
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2691

Met Glu Lys Thr Ile Glu Asn Gln Thr Gln Ser Lys Arg Thr Leu Asn 
1               5                   10                  15      


Asn Thr Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Asp Glu Glu Lys Ile Thr Thr Ser Phe Leu Val Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Arg Gln Ser Leu Val Tyr Ser Asn Leu Thr 
65                  70                  75                  80  


Arg Tyr Met His Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Asp 
                85                  90                  95      


Asp Glu Arg Asp Lys Ala Glu Asn Tyr Gly Lys Asp Phe Gly Asn Leu 
            100                 105                 110         


Thr Asp Thr Leu Lys Glu Ile Phe Lys Glu Leu Asn Glu Phe Arg Asn 
        115                 120                 125             


Asp Tyr Ser His Tyr Tyr Ser Thr Glu Lys Lys Asp Lys Arg Lys Thr 
    130                 135                 140                 


Ile Val Ser Asp Lys Leu Lys Asn Phe Leu Asn Ile Asn Tyr Thr Arg 
145                 150                 155                 160 


Ala Ile Lys Tyr Thr Lys Ser Arg Phe Ile Asn Val Phe Ser Asp Asn 
                165                 170                 175     


Asn Phe Cys Leu Ala Glu Glu Ala Lys His Val Glu Asn Asp Asn Thr 
            180                 185                 190         


Ile Thr Gln Asp Gly Ile Val Phe Phe Thr Ser Met Phe Leu Asp Arg 
        195                 200                 205             


Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile Ile Gly Leu Lys Gly Thr 
    210                 215                 220                 


Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Thr Leu Met Ala Phe Cys 
225                 230                 235                 240 


Val Asn Leu Pro His Asp Lys Phe Val Ser Glu Asn Ser Glu Gln Gln 
                245                 250                 255     


Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu 
            260                 265                 270         


Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln His Phe Leu Pro Lys Leu 
        275                 280                 285             


Asp Asp Glu Gln Ile Asp Asn Val Leu Glu Asn Ser Val Pro Tyr Thr 
    290                 295                 300                 


Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn Ile Thr Lys Lys Val Arg 
305                 310                 315                 320 


Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu Lys Phe Ile Asp Gln Lys 
                325                 330                 335     


Lys Leu Phe Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val 
            340                 345                 350         


Leu Asp Glu Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Lys Arg Thr 
        355                 360                 365             


Val Thr Glu Asn Thr Lys Ala Phe Gly Met Leu Gln Asp Leu Asn Asp 
    370                 375                 380                 


Glu Glu Asn Val Leu Asn Lys Ile Asn Thr Gly Glu Ser Lys Ala Lys 
385                 390                 395                 400 


Phe Asp Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Thr Lys Asn 
            420                 425                 430         


Thr Asp Asn Lys Ile Lys Ser Asn Leu Leu Gln Pro Leu Pro Glu Ala 
        435                 440                 445             


Phe Leu Ser Ile Asn Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
    450                 455                 460                 


Glu Gln Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn 
465                 470                 475                 480 


Asn Ser Lys Ile Leu Asn Lys Glu Phe Ile Lys Ala Ile Lys Leu Lys 
                485                 490                 495     


Leu Asn Asp Leu Asp Val Phe Tyr Lys Arg Ser Gln Gly Arg Lys Gln 
            500                 505                 510         


Lys His Ala Tyr Leu Thr Lys Asp Lys Lys Tyr Asp Asn Glu Lys Ile 
        515                 520                 525             


Asn Glu Leu Lys Asn Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu 
    530                 535                 540                 


Tyr Asn Leu Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp 
545                 550                 555                 560 


Leu Asn Ile Ala Asp Val Gln Ala Lys Asn Ala Ile Ser Asp Arg Ile 
                565                 570                 575     


Lys Leu Met Lys Arg Asp Cys Ile Asn Arg Leu Lys Ser Met Lys Lys 
            580                 585                 590         


Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp 
        595                 600                 605             


Ile Val Asp Met Ile Ile Asp Glu Glu Lys Lys Lys Lys Ile Thr Ser 
    610                 615                 620                 


Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Lys 
625                 630                 635                 640 


Glu Lys Lys Glu Leu Phe Ile Leu Ile Cys Asn Asn Glu Leu Lys Leu 
                645                 650                 655     


Asn Asp Asp Asp Gly His Pro Phe Phe Lys Asn Ile Asn Phe Ser Asn 
            660                 665                 670         


Tyr Lys Tyr Thr Ser Glu Ile Tyr Gln Lys Tyr Leu Glu Glu Lys Gly 
        675                 680                 685             


His Lys Met Val Lys Glu Tyr Asn Pro Arg Lys Glu Asn Tyr Val Glu 
    690                 695                 700                 


Lys Asp Lys Ser Trp Leu Glu Ile Asn Phe Tyr Lys Lys Glu Trp Asn 
705                 710                 715                 720 


Glu Asn Ala Lys Lys Asp Leu Thr Val Val Lys Leu Pro Asp Asp Lys 
                725                 730                 735     


Ser Lys Ile Pro Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser 
            740                 745                 750         


Phe Glu Asn Trp Phe Lys Tyr Val Thr Asn Gly Lys Glu Thr Thr Asp 
        755                 760                 765             


Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp Glu Thr Leu 
    770                 775                 780                 


Lys Glu Leu Phe Lys Lys Glu Leu Ser Lys Asn Asn Ile Glu Phe Lys 
785                 790                 795                 800 


Glu Glu Asp Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Asp Lys Cys 
                805                 810                 815     


Arg Asn Asp Lys Thr Gln Lys Phe Tyr Ser Ala Glu Arg Glu Tyr Thr 
            820                 825                 830         


Phe Glu Glu Glu Lys Leu Asn Phe His Ile Asn Thr Lys Ser Lys Phe 
        835                 840                 845             


Glu Glu Tyr Ile Asn Pro Glu Phe Ala Glu Lys Val Phe Arg Leu Lys 
    850                 855                 860                 


Asn Gln Asn Arg Glu Lys Asp Asn Ile Ser Gly Arg Arg Leu Pro Pro 
865                 870                 875                 880 


Leu Lys Met Lys Glu Val Thr Lys Asn Met Val Lys Arg Ile Gly Asn 
                885                 890                 895     


Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Leu Met Leu 
            900                 905                 910         


Leu Met Phe Glu Lys Leu Val Asp Asn Asn Leu Lys Leu Lys Leu Glu 
        915                 920                 925             


Asn Val Asp Lys Leu Leu Asn Glu Ser Ile Glu Ile Asn Gln Ser Ile 
    930                 935                 940                 


Ser Gly Lys Leu Ser Phe Asp Asp Ser Gly Asp Asn Glu Asn Lys Lys 
945                 950                 955                 960 


Asp Arg Ala Ile Ile Cys Arg Asn Ile Thr Glu Thr Arg Lys Arg Lys 
                965                 970                 975     


Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Glu Glu Glu  Asn Ile Pro Ile Glu  Lys Ile Lys 
        995                 1000                 1005             


Ile Glu  Leu Asp Thr Tyr Ser  Lys Ala Lys Asp Val  Val Phe Asp 
    1010                 1015                 1020             


Leu Ile  Phe Asp Leu Glu Arg  Ala Ile Ile Asn Lys  Asp Glu Asn 
    1025                 1030                 1035             


Arg Ile  Lys Glu Leu Asn Lys  Asp Lys Asn Gly Val  Ile Gln Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Phe Trp Leu  Leu Glu Lys 
    1055                 1060                 1065             


Asn Leu  Ile Thr Glu Gln Glu  Phe Thr Phe Met Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Thr  Phe Ser His Asn Gln  Phe Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Leu Phe  Ile Lys Asn Trp Asn  Glu Asn Glu Phe Ala  Lys Gln Ile 
    1100                 1105                 1110             


Leu Asn  Val Tyr Asn Gln Lys  Asn Asn Asn Leu Ile  Lys Ser Ile 
    1115                 1120                 1125             


Lys Asp  Ile 
    1130     


<210>  2692
<211>  1126
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2692

Met Glu Thr Leu Thr Ile Pro Glu Val Ile Lys Cys Arg Thr Leu Ser 
1               5                   10                  15      


Asp Asp Pro Gln Phe Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Val Phe Asn Ile Ser Asn His Ile Ala Lys Glu Phe Asp Leu Pro Leu 
        35                  40                  45              


Leu Ala Glu Glu Asp His Leu Arg Asn Ser Phe Leu Cys Asn Lys Glu 
    50                  55                  60                  


Asn Lys Lys Ile Asn Trp Asn His Leu Tyr Ser Arg Thr Asn Arg Phe 
65                  70                  75                  80  


Leu Ser Val Leu Lys Val Phe Asp Ala Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Lys Thr Thr Asn Leu Glu Gly Lys Asp Phe Ala Leu Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Ile Val Phe Gly Glu Leu Gln Asp Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Thr Ile Arg Lys Thr Thr Val 
    130                 135                 140                 


Ser Asp Glu Met Ala Leu Phe Leu Lys Val Asn Phe Asn Arg Ala Ile 
145                 150                 155                 160 


Glu Tyr Thr Lys Glu Arg Phe Lys Gly Val Leu Asn Glu Glu Asp Phe 
                165                 170                 175     


Gln Leu Val Ala Ser Lys Lys Val Met Glu Ala Asn Leu Thr Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Cys Leu Ile Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Thr Gly Leu Lys Gly Thr Glu Asn 
    210                 215                 220                 


Lys Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro His Asp Arg Phe Gln Ser Asp Asn Thr Arg Gln Ala Phe Ser 
                245                 250                 255     


Leu Asp Leu Ile Asn Glu Leu Asn Arg Cys Pro Lys Val Leu Tyr Asn 
            260                 265                 270         


Ser Ile Thr Ala Ser Gly Lys Gln Ile Phe Gln Pro Lys Leu Asp Ile 
        275                 280                 285             


Leu Gly Ile Lys Asn Leu Leu Asp Asn Ser Thr Asn Ile Asp Glu Glu 
    290                 295                 300                 


Val Glu Asp Tyr Asp Glu Tyr Ile Glu Ala Leu Thr Lys Arg Ile Arg 
305                 310                 315                 320 


His Ser Asn Arg Phe Ser Asp Phe Ala Leu Lys Tyr Ile Asp Glu Thr 
                325                 330                 335     


Gly Ile Phe Asp Lys Phe Arg Phe Gln Ile Asp Leu Gly Lys Leu Leu 
            340                 345                 350         


Val Asp Glu Tyr Ala Lys Phe Phe Asn Ser Glu Glu Val Pro Arg Arg 
        355                 360                 365             


Ile Ile Glu Asn Val Lys Ala Phe Gly Lys Leu Asn Ser Phe Asn Asp 
    370                 375                 380                 


Glu Ala Lys Val Leu Thr Arg Ile Gly Asn Gly Tyr Pro Ser Lys Glu 
385                 390                 395                 400 


Phe Glu Gln Phe Ser Pro His Tyr Asn Thr Glu Asn Asn Lys Ile Gly 
                405                 410                 415     


Ile Ser Val Lys Glu Asp Thr Ala Lys Leu Arg Pro Asn Ser Lys Gly 
            420                 425                 430         


Glu Thr Gly Lys Lys Leu His Gln Pro Leu Pro Glu Ala Phe Leu Ser 
        435                 440                 445             


Leu His Glu Leu Pro Lys Val Ile Ile Leu Asp Tyr Leu Gln Lys Gly 
    450                 455                 460                 


Glu Pro Glu Arg Leu Ile Glu Asp Phe Ile Leu Ile Asn Asn Ser Lys 
465                 470                 475                 480 


Leu Met Thr Met Pro Phe Ile Glu Ala Val Lys Ser Gln Met Pro Lys 
                485                 490                 495     


Glu Trp Asp Asp Phe Arg Arg Arg Thr Asp Thr Lys Lys Glu Met Ala 
            500                 505                 510         


Tyr Asn Glu Lys Thr Leu Thr Tyr Leu Leu Glu Arg Lys Asn Thr Leu 
        515                 520                 525             


Asn Gln Val Leu Ala Glu Tyr Gln Leu Asn Asp Lys Gln Ile Pro Gly 
    530                 535                 540                 


Arg Ile Leu Asp Tyr Trp Leu Asn Ile Lys Asp Val Glu Glu Gly Arg 
545                 550                 555                 560 


Ala Val Ser Asp Arg Ile Lys Ser Ile Lys Arg Asp Cys Met Ser Arg 
                565                 570                 575     


Leu Arg Ala Leu Glu Lys Phe Lys Ile Asp Arg Asn Arg Asn Lys Ile 
            580                 585                 590         


Pro Lys Ile Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile Val Asp 
        595                 600                 605             


Met Val Ala Gly Glu Glu Lys Lys Gln Lys Ile Thr Ser Phe Tyr Tyr 
    610                 615                 620                 


Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Ser Asp Lys Lys 
625                 630                 635                 640 


Gln Leu Phe Ile His Thr Val Cys Asn Glu Leu Arg Leu Asn Glu Thr 
                645                 650                 655     


Gly Gly His Pro Phe Leu Tyr Lys Leu Asp Leu Gln His Ile Asn Ser 
            660                 665                 670         


Thr Ser Glu Phe Tyr Gly Lys Tyr Leu Gln Glu Lys Gly His Lys Met 
        675                 680                 685             


Val Arg Glu Lys Asn Leu Arg Thr Gly Arg Val Ala Glu Val Asp Gln 
    690                 695                 700                 


Ser Trp Met Ala Thr Thr Phe Tyr Lys Lys Glu Trp Asn Glu Lys Ile 
705                 710                 715                 720 


Gly Lys Gln Leu Thr Val Val Lys Leu Pro Leu Asn Lys Ser Lys Ile 
                725                 730                 735     


Pro Phe Thr Leu Arg Leu Leu Glu Glu Lys Thr Ile Tyr Thr Leu Asp 
            740                 745                 750         


Gln Trp Leu Gln Asn Leu Thr Lys Gly Arg Asn Pro Asn Asp Ala Lys 
        755                 760                 765             


His Pro Val Asn Leu Pro Thr Asn Leu Phe Asp Glu Arg Leu Thr Val 
    770                 775                 780                 


Leu Leu Arg His Asp Leu Asp Glu Arg Gln Ile Ser Tyr Pro Ser Asn 
785                 790                 795                 800 


Ser Tyr Asp Asn Glu Leu Phe Lys Ile Trp Trp Lys Ser Arg Ser Asp 
                805                 810                 815     


Ser Thr Gln Ser Phe Tyr Asn Ala Glu Arg Glu Tyr Val Ile Phe Gly 
            820                 825                 830         


Glu Lys Val Asn Phe Met Pro Asn Thr Lys Asp Asn Phe Ala Asp Tyr 
        835                 840                 845             


Tyr Gln His Ala Phe Thr Thr Ala Tyr Gln Lys Lys Arg Lys Glu Arg 
    850                 855                 860                 


Thr Leu Gln Gln Lys Glu Asp Arg Arg Leu Pro Asn Ile Gln Leu Glu 
865                 870                 875                 880 


Gln Val Glu Lys Thr Phe Lys Gln Thr Ile Ala Gly Thr Glu Lys Glu 
                885                 890                 895     


Ile Arg Met Leu Gln Glu Glu Asp Arg Ile Met Leu Leu Met Ile Glu 
            900                 905                 910         


Ser Leu Leu Glu Asp Gly Lys Lys Met Gln Leu Lys Leu Ser Glu Ile 
        915                 920                 925             


Asp Thr Leu Leu Asn Ala Ala Thr Glu Val Lys Gln Thr Val Ser Ala 
    930                 935                 940                 


Lys Leu Ser Phe Asn Asp Ser Gly Glu Leu Ile Lys Asp Lys Thr Asn 
945                 950                 955                 960 


Pro Ala Ile Val Arg Thr Ile Thr Val Ser Arg Lys Arg Lys Asp Tyr 
                965                 970                 975     


Ser Met Leu Arg Lys Phe Ile Phe Asp Arg Arg Leu Pro Glu Leu Phe 
            980                 985                 990         


Glu Tyr Phe Pro Glu Lys Glu Ile  Gln Leu Asp Ser Leu  Lys Glu Glu 
        995                 1000                 1005             


Leu Asp  Ala Tyr Asn Lys Ala  Lys His Glu Val Phe  Asp Val Val 
    1010                 1015                 1020             


Phe Glu  Leu Glu Ala Lys Ile  Ile Ala Lys Asp Ser  Asp Gly Ile 
    1025                 1030                 1035             


Gln Gln  Leu Phe Ala Asp Glu  Ser Gly Lys Pro Leu  Thr Gly Asn 
    1040                 1045                 1050             


Ile Gln  His Lys Pro Tyr Leu  Thr Trp Leu Lys Asn  Lys Gly Leu 
    1055                 1060                 1065             


Leu Asp  Asp Asn Thr Phe Thr  Phe Leu Asn Met Val  Arg Asn Cys 
    1070                 1075                 1080             


Phe Ser  His Asn Gln Tyr Pro  Gln Lys Lys Thr Met  Glu Arg Leu 
    1085                 1090                 1095             


Ile His  His Trp Glu Pro Asn  Arg Phe Ala Leu Thr  Ile Ala Ser 
    1100                 1105                 1110             


Lys Tyr  Lys Gln Glu Ile Ala  Arg Ile Met Glu Asp  Leu 
    1115                 1120                 1125     


<210>  2693
<211>  1126
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2693

Met Glu Thr Leu Thr Ile Pro Glu Val Ile Lys Cys Arg Thr Leu Ser 
1               5                   10                  15      


Asp Asp Pro Gln Phe Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Val Phe Asn Ile Ser Asn His Ile Ala Lys Glu Phe Asp Leu Pro Leu 
        35                  40                  45              


Leu Ala Glu Glu Asp His Leu Arg Asn Ser Phe Leu Cys Asn Lys Glu 
    50                  55                  60                  


Asn Lys Lys Ile Asn Trp Asn His Leu Tyr Ser Arg Thr Asn Arg Phe 
65                  70                  75                  80  


Leu Ser Val Leu Lys Val Phe Asp Ala Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Lys Thr Thr Asn Leu Glu Gly Lys Asp Phe Ala Leu Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Ile Val Phe Gly Glu Leu Gln Asp Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Thr Ile Arg Lys Thr Thr Val 
    130                 135                 140                 


Ser Asp Glu Met Ala Leu Phe Leu Lys Val Asn Phe Asn Arg Ala Ile 
145                 150                 155                 160 


Glu Tyr Thr Lys Glu Arg Phe Lys Gly Val Leu Asn Glu Glu Asp Phe 
                165                 170                 175     


Gln Leu Val Ala Ser Lys Lys Val Met Glu Ala Asn Leu Thr Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Cys Leu Ile Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Thr Gly Leu Lys Gly Thr Glu Asn 
    210                 215                 220                 


Lys Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro His Asp Arg Phe Gln Ser Asp Asn Thr Arg Gln Ala Phe Ser 
                245                 250                 255     


Leu Asp Leu Ile Asn Glu Leu Asn Arg Cys Pro Lys Val Leu Tyr Asn 
            260                 265                 270         


Ser Ile Thr Ala Ser Gly Lys Gln Ile Phe Gln Pro Lys Leu Asp Ile 
        275                 280                 285             


Leu Gly Ile Lys Asn Leu Leu Asp Asn Ser Thr Asn Ile Asp Glu Glu 
    290                 295                 300                 


Val Glu Asp Tyr Asp Glu Tyr Ile Glu Ala Leu Thr Lys Arg Ile Arg 
305                 310                 315                 320 


His Ser Asn Arg Phe Ser Asp Phe Ala Leu Lys Tyr Ile Asp Glu Thr 
                325                 330                 335     


Gly Ile Phe Asp Lys Phe Arg Phe Gln Ile Asp Leu Gly Lys Leu Leu 
            340                 345                 350         


Val Asp Glu Tyr Ala Lys Phe Phe Asn Ser Glu Glu Val Pro Arg Arg 
        355                 360                 365             


Ile Ile Glu Asn Val Lys Ala Phe Gly Lys Leu Asn Ser Phe Asn Asp 
    370                 375                 380                 


Glu Ala Lys Val Leu Thr Arg Ile Gly Asn Gly Tyr Pro Ser Lys Glu 
385                 390                 395                 400 


Phe Glu Gln Phe Ser Pro His Tyr Asn Thr Glu Asn Asn Lys Ile Gly 
                405                 410                 415     


Ile Ser Val Lys Glu Asp Thr Ala Lys Leu Arg Pro Asn Ser Lys Gly 
            420                 425                 430         


Glu Thr Gly Lys Lys Leu His Gln Pro Leu Pro Glu Ala Phe Leu Ser 
        435                 440                 445             


Leu His Glu Leu Pro Lys Val Ile Ile Leu Asp Tyr Leu Gln Lys Gly 
    450                 455                 460                 


Glu Pro Glu Arg Leu Ile Glu Asp Phe Ile Leu Ile Asn Asn Ser Lys 
465                 470                 475                 480 


Leu Met Thr Met Pro Phe Ile Glu Ala Val Lys Ser Gln Met Pro Lys 
                485                 490                 495     


Glu Trp Asp Asp Phe Arg Arg Arg Thr Asp Thr Lys Lys Glu Met Ala 
            500                 505                 510         


Tyr Asn Glu Lys Thr Leu Thr Tyr Leu Leu Glu Arg Lys Asn Thr Leu 
        515                 520                 525             


Asn Gln Val Leu Ala Glu Tyr Gln Leu Asn Asp Lys Gln Ile Pro Gly 
    530                 535                 540                 


Arg Ile Leu Asp Tyr Trp Leu Asn Ile Lys Asp Val Glu Glu Gly Arg 
545                 550                 555                 560 


Ala Val Ser Asp Arg Ile Lys Ser Ile Lys Arg Asp Cys Met Ser Arg 
                565                 570                 575     


Leu Arg Ala Leu Glu Lys Phe Lys Ile Asp Arg Asn Arg Asn Lys Ile 
            580                 585                 590         


Pro Lys Ile Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile Val Asp 
        595                 600                 605             


Met Val Ala Gly Glu Glu Lys Lys Gln Lys Ile Thr Ser Phe Tyr Tyr 
    610                 615                 620                 


Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Ser Asp Lys Lys 
625                 630                 635                 640 


Gln Leu Phe Ile His Thr Val Cys Asn Glu Leu Arg Leu Asn Glu Thr 
                645                 650                 655     


Gly Gly His Pro Phe Leu Tyr Lys Leu Asp Leu Gln His Ile Asn Ser 
            660                 665                 670         


Thr Ser Glu Phe Tyr Gly Lys Tyr Leu Gln Glu Lys Gly His Lys Met 
        675                 680                 685             


Val Arg Glu Lys Asn Leu Arg Thr Gly Arg Val Ala Glu Val Asp Gln 
    690                 695                 700                 


Ser Trp Met Ala Thr Thr Phe Tyr Lys Lys Glu Trp Asn Glu Lys Ile 
705                 710                 715                 720 


Gly Lys Gln Leu Thr Val Val Lys Leu Pro Leu Asn Lys Ser Lys Ile 
                725                 730                 735     


Pro Phe Thr Leu Arg Leu Leu Glu Glu Lys Thr Ile Tyr Thr Leu Asp 
            740                 745                 750         


Gln Trp Leu Gln Asn Leu Thr Lys Gly Arg Asn Pro Asn Asp Ala Lys 
        755                 760                 765             


His Pro Val Asn Leu Pro Thr Asn Leu Phe Asp Glu Arg Leu Thr Val 
    770                 775                 780                 


Leu Leu Arg His Asp Leu Asp Glu Arg Gln Ile Ser Tyr Pro Ser Asn 
785                 790                 795                 800 


Ser Tyr Asp Asn Glu Leu Phe Lys Ile Trp Trp Lys Ser Arg Ser Asp 
                805                 810                 815     


Ser Thr Gln Ser Phe Tyr Asn Ala Glu Arg Glu Tyr Val Ile Phe Gly 
            820                 825                 830         


Glu Lys Val Asn Phe Met Pro Asn Thr Lys Asp Asn Phe Ala Asp Tyr 
        835                 840                 845             


Tyr Gln His Ala Phe Thr Thr Ala Tyr Gln Lys Lys Arg Lys Glu Arg 
    850                 855                 860                 


Thr Leu Gln Gln Lys Glu Asp Arg Arg Leu Pro Asn Ile Gln Leu Glu 
865                 870                 875                 880 


Gln Val Glu Lys Thr Phe Lys Gln Thr Ile Ala Gly Thr Glu Lys Glu 
                885                 890                 895     


Ile Arg Met Leu Gln Glu Glu Asp Arg Ile Met Leu Leu Met Ile Glu 
            900                 905                 910         


Ser Leu Leu Glu Asp Gly Lys Lys Met Gln Leu Lys Leu Ser Glu Ile 
        915                 920                 925             


Asp Thr Leu Leu Asn Ala Ala Thr Glu Val Lys Gln Thr Val Ser Ala 
    930                 935                 940                 


Lys Leu Ser Phe Asn Asp Ser Gly Glu Leu Ile Lys Asp Lys Thr Asn 
945                 950                 955                 960 


Pro Ala Ile Val Arg Thr Ile Thr Val Ser Arg Lys Arg Lys Asp Tyr 
                965                 970                 975     


Ser Met Leu Arg Lys Phe Ile Phe Asp Arg Arg Leu Pro Glu Leu Phe 
            980                 985                 990         


Glu Tyr Phe Pro Glu Lys Glu Ile  Gln Leu Asp Ser Leu  Lys Glu Glu 
        995                 1000                 1005             


Leu Asp  Ala Tyr Asn Lys Ala  Lys His Glu Val Phe  Asp Val Val 
    1010                 1015                 1020             


Phe Glu  Leu Glu Ala Lys Ile  Ile Ala Lys Asp Ser  Asp Gly Ile 
    1025                 1030                 1035             


Gln Gln  Leu Phe Ala Asp Glu  Ser Gly Lys Pro Leu  Thr Gly Asn 
    1040                 1045                 1050             


Ile Gln  His Lys Pro Tyr Leu  Thr Trp Leu Lys Asn  Lys Gly Leu 
    1055                 1060                 1065             


Leu Asp  Asp Asn Thr Phe Thr  Phe Leu Asn Met Val  Arg Asn Cys 
    1070                 1075                 1080             


Phe Ser  His Asn Gln Tyr Pro  Gln Lys Lys Thr Met  Glu Arg Leu 
    1085                 1090                 1095             


Ile His  His Trp Glu Pro Asn  Arg Phe Ala Leu Thr  Ile Ala Ser 
    1100                 1105                 1110             


Lys Tyr  Lys Gln Glu Ile Ala  Arg Ile Met Glu Asp  Leu 
    1115                 1120                 1125     


<210>  2694
<211>  1131
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2694

Met Glu Lys Thr Ile Glu Asn Gln Thr Gln Ser Lys Arg Thr Leu Asn 
1               5                   10                  15      


Asn Thr Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Asp Glu Glu Lys Ile Thr Thr Ser Phe Leu Val Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Arg Gln Ser Leu Val Tyr Ser Asn Leu Ile 
65                  70                  75                  80  


Arg Tyr Met His Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Asp 
                85                  90                  95      


Asp Glu Arg Asp Lys Ala Glu Asn Tyr Gly Lys Asp Phe Gly Asn Leu 
            100                 105                 110         


Thr Asp Thr Leu Lys Glu Ile Phe Lys Glu Leu Asn Glu Phe Arg Asn 
        115                 120                 125             


Asp Tyr Ser His Tyr Tyr Ser Thr Glu Lys Lys Asp Lys Arg Lys Thr 
    130                 135                 140                 


Ile Val Ser Asp Lys Leu Lys Asn Phe Leu Asn Ile Asn Tyr Thr Arg 
145                 150                 155                 160 


Ala Ile Lys Tyr Thr Lys Ser Arg Phe Ile Asn Val Phe Ser Asp Asn 
                165                 170                 175     


Asn Phe Cys Leu Ala Glu Glu Ala Lys His Val Glu Asn Asp Asn Thr 
            180                 185                 190         


Ile Thr Gln Asp Gly Ile Val Phe Phe Thr Ser Met Phe Leu Asp Arg 
        195                 200                 205             


Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile Ile Gly Leu Lys Gly Thr 
    210                 215                 220                 


Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Thr Leu Met Ala Phe Cys 
225                 230                 235                 240 


Val Asn Leu Pro His Asp Lys Phe Val Ser Glu Asn Ser Glu Gln Gln 
                245                 250                 255     


Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu 
            260                 265                 270         


Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln His Phe Leu Pro Lys Leu 
        275                 280                 285             


Asp Asp Glu Gln Ile Asp Asn Val Leu Glu Asn Ser Val Pro Tyr Thr 
    290                 295                 300                 


Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn Ile Thr Lys Lys Val Arg 
305                 310                 315                 320 


Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu Lys Phe Ile Asp Gln Lys 
                325                 330                 335     


Lys Leu Phe Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val 
            340                 345                 350         


Leu Asp Glu Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Lys Arg Thr 
        355                 360                 365             


Val Thr Glu Asn Thr Lys Ala Phe Gly Met Leu Gln Asp Leu Asn Asp 
    370                 375                 380                 


Glu Glu Asn Val Leu Asn Lys Ile Asn Thr Gly Glu Ser Lys Ala Lys 
385                 390                 395                 400 


Phe Asp Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Thr Lys Asn 
            420                 425                 430         


Thr Asp Asn Lys Ile Lys Ser Asn Leu Leu Gln Pro Leu Pro Glu Ala 
        435                 440                 445             


Phe Leu Ser Ile Asn Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
    450                 455                 460                 


Glu Gln Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn 
465                 470                 475                 480 


Asn Ser Lys Ile Leu Asn Lys Glu Phe Ile Lys Ala Ile Lys Leu Lys 
                485                 490                 495     


Leu Asn Asp Leu Asp Val Phe Tyr Lys Arg Ser Gln Gly Arg Lys Gln 
            500                 505                 510         


Lys His Ala Tyr Leu Thr Lys Asp Lys Lys Tyr Asp Asn Glu Lys Ile 
        515                 520                 525             


Asn Glu Leu Lys Asn Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu 
    530                 535                 540                 


Tyr Asn Leu Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp 
545                 550                 555                 560 


Leu Asn Ile Ala Asp Val Gln Ala Lys Asn Ala Ile Ser Asp Arg Ile 
                565                 570                 575     


Lys Leu Met Lys Arg Asp Cys Ile Asn Arg Leu Lys Ser Met Lys Lys 
            580                 585                 590         


Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp 
        595                 600                 605             


Ile Val Asp Met Ile Ile Asp Glu Glu Lys Lys Lys Lys Ile Thr Ser 
    610                 615                 620                 


Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Lys 
625                 630                 635                 640 


Glu Lys Lys Glu Leu Phe Ile Leu Ile Cys Asn Asn Glu Leu Lys Leu 
                645                 650                 655     


Asn Asp Asp Asp Gly His Pro Phe Phe Lys Asn Ile Asn Phe Ser Asn 
            660                 665                 670         


Tyr Lys Tyr Thr Ser Glu Ile Tyr Gln Lys Tyr Leu Glu Glu Lys Gly 
        675                 680                 685             


His Lys Met Val Lys Glu Tyr Asn Pro Arg Lys Glu Asn Tyr Val Glu 
    690                 695                 700                 


Lys Asp Lys Ser Trp Leu Glu Ile Asn Phe Tyr Lys Lys Glu Trp Asn 
705                 710                 715                 720 


Glu Asn Ala Lys Lys Asp Leu Thr Val Val Lys Leu Pro Asp Asp Lys 
                725                 730                 735     


Ser Lys Ile Pro Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser 
            740                 745                 750         


Phe Glu Asn Trp Phe Lys Tyr Val Thr Asn Gly Lys Glu Thr Thr Asp 
        755                 760                 765             


Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp Glu Thr Leu 
    770                 775                 780                 


Lys Glu Leu Leu Lys Lys Glu Leu Ser Lys Asn Asn Ile Glu Phe Lys 
785                 790                 795                 800 


Glu Glu Asp Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Asp Lys Cys 
                805                 810                 815     


Arg Asn Asp Lys Thr Gln Lys Phe Tyr Ser Ala Glu Arg Glu Tyr Thr 
            820                 825                 830         


Phe Glu Glu Glu Lys Leu Asn Phe His Ile Asn Thr Lys Ser Lys Phe 
        835                 840                 845             


Glu Glu Tyr Ile Asn Pro Glu Phe Ala Glu Lys Val Phe Arg Leu Lys 
    850                 855                 860                 


Asn Gln Asn Arg Glu Lys Asp Asn Ile Ser Gly Arg Arg Leu Pro Pro 
865                 870                 875                 880 


Leu Lys Met Lys Glu Val Thr Lys Asn Met Val Lys Arg Ile Gly Asn 
                885                 890                 895     


Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Leu Met Leu 
            900                 905                 910         


Leu Met Phe Glu Lys Leu Val Asp Asn Asn Leu Lys Leu Lys Leu Glu 
        915                 920                 925             


Asn Val Asp Lys Leu Leu Asn Glu Ser Ile Glu Ile Asn Gln Ser Ile 
    930                 935                 940                 


Ser Gly Lys Leu Ser Phe Asp Asp Ser Gly Asp Asn Glu Asn Lys Lys 
945                 950                 955                 960 


Asp Arg Ala Ile Ile Cys Arg Asn Ile Thr Glu Thr Arg Lys Arg Lys 
                965                 970                 975     


Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Glu Glu Glu  Asn Ile Pro Ile Glu  Lys Ile Lys 
        995                 1000                 1005             


Ile Glu  Leu Asp Thr Tyr Ser  Lys Ala Lys Asp Val  Val Phe Asp 
    1010                 1015                 1020             


Leu Ile  Phe Asp Leu Glu Arg  Ala Ile Ile Asn Lys  Asp Glu Asn 
    1025                 1030                 1035             


Arg Ile  Lys Glu Leu Asn Lys  Asp Lys Asn Gly Val  Ile Gln Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Phe Trp Leu  Leu Glu Lys 
    1055                 1060                 1065             


Asn Leu  Ile Thr Glu Gln Glu  Phe Thr Phe Met Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Thr  Phe Ser His Asn Gln  Phe Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Leu Phe  Ile Lys Asn Trp Asn  Glu Asn Glu Phe Ala  Lys Gln Ile 
    1100                 1105                 1110             


Leu Asn  Val Tyr Asn Gln Lys  Asn Asn Asn Leu Ile  Lys Ser Ile 
    1115                 1120                 1125             


Lys Asp  Ile 
    1130     


<210>  2695
<211>  1196
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2695

Met Val Glu Ile Thr Asn Asn Lys Asn Val Tyr Ala Ala Phe Ser Asn 
1               5                   10                  15      


Met Ala Gln Asp Asn Leu Tyr Met Val Phe Asn His Ile Leu Lys Cys 
            20                  25                  30          


Leu Gly Lys Asn Ala Gly Lys Asn Ala Ala Asp Lys Ile Gln Gln Thr 
        35                  40                  45              


Phe Ala Ser Lys Lys Val Asn Glu Lys Ala Lys Ala Ile Asp Leu Leu 
    50                  55                  60                  


Asn Arg His Leu Pro Phe Met Glu Pro Leu Val Ala Ser Val Met Asp 
65                  70                  75                  80  


Lys Lys Gly Asn Asn Phe Ser Leu Pro Glu Ala Tyr Ala Tyr Val Thr 
                85                  90                  95      


Lys Arg Ile Val Glu Ile Ala Arg Phe Tyr Arg Asn Tyr Thr Thr His 
            100                 105                 110         


Tyr Asp Ser Asp Glu Ser Gly Glu Ile Leu Asn Leu Asn Ser Tyr Glu 
        115                 120                 125             


Gly Ser Met Cys His Gly Leu Asn Glu Leu Phe Lys Ala Ser Ile Arg 
    130                 135                 140                 


Val Val Arg Gln Arg Tyr Gly Tyr Thr Glu Asp Asp Val Lys Phe Val 
145                 150                 155                 160 


Ala Asn Arg Gly Lys Ala Pro Gly Asn Glu Lys Ser Tyr Lys Tyr Phe 
                165                 170                 175     


Leu His Lys Thr Val Thr Ser Ala Ala Asn Ser Thr Gln Arg Lys Glu 
            180                 185                 190         


Phe Ser Leu Lys Gly Leu Val Phe Phe Leu Cys Leu Leu Leu Glu Lys 
        195                 200                 205             


Lys Tyr Ile Ser Glu Phe Leu Asp Lys Thr Lys Ala Phe Tyr Thr Tyr 
    210                 215                 220                 


Gln Asp Leu Thr Asn Pro Lys Arg Lys Ser Ile Leu Leu Glu Ser Ile 
225                 230                 235                 240 


Ala Val Tyr Arg Val Lys Leu Pro Arg Lys Arg Tyr Asp Ser Glu Thr 
                245                 250                 255     


Ser Leu Thr Val Leu Ala Leu Asp Ile Met Asn Glu Leu Gln Arg Cys 
            260                 265                 270         


Pro Arg Glu Leu Phe Asp Ile Leu Ser Pro Ala Asp Gln Lys Leu Phe 
        275                 280                 285             


Arg Ser Val Lys Gly Asp Glu Asn Gly Glu Ser Val Leu Met Met Arg 
    290                 295                 300                 


Ser Ser Asp Arg Phe Pro Thr Leu Ala Met Arg Trp Ile Asp Leu Cys 
305                 310                 315                 320 


Glu Thr Phe Lys Gln Ile Arg Phe Gln Ile Asn Leu Gly Lys Tyr Arg 
                325                 330                 335     


Phe Ala Phe Tyr Asn Lys Arg Cys Ile Lys Tyr Gly Glu Asp Asn Gly 
            340                 345                 350         


Val Gln Val Arg Ser Leu Glu Lys Glu Leu His Gly Phe Gly Arg Leu 
        355                 360                 365             


Asp Asp Ile Glu Lys Asp Arg Arg Glu Lys Trp Ala Thr Leu Ile Arg 
    370                 375                 380                 


Glu Tyr Asp Glu Val Arg Glu Asp Thr Ala Asp Ser Val Pro Tyr Ile 
385                 390                 395                 400 


Thr Asp His Arg Ala Ser Tyr Leu Ile Ser Asn Asn Arg Val Gly Leu 
                405                 410                 415     


Tyr Trp Lys Ala Ser Val Thr Asp Pro Phe Pro Gly Leu Pro Gln Leu 
            420                 425                 430         


Ser Thr Thr Pro Gln Ala Arg Asp Leu Arg Glu Arg Lys Lys Ala Gly 
        435                 440                 445             


Glu Lys Leu Ala Ser Leu Ala Thr Pro Lys Cys Phe Leu Ser Val His 
    450                 455                 460                 


Glu Leu Pro Ser Leu Val Phe Tyr Thr Met Leu Phe Lys Gln Ala Asp 
465                 470                 475                 480 


Pro Ser Val Leu Gln Lys Ser Gly Ala Ile Ser Ala Glu Ala Ile Ile 
                485                 490                 495     


Met Arg Trp Val Lys Asn Phe His Ser Phe Ile Asp Gly Val Leu Ser 
            500                 505                 510         


Gly Glu Ile Ser Lys Asp Asn Cys Glu Asp Lys Ala Ala Asp Leu Gly 
        515                 520                 525             


Ile Asp Tyr Lys Arg His Leu Pro Lys Lys Leu Gln Glu Phe Ile Ser 
    530                 535                 540                 


Gly Ser Gly Ala Asp Glu Gln Glu Leu Asn Lys Arg Leu Arg Asp Arg 
545                 550                 555                 560 


Leu Asp Lys His Ile Ala Asp Thr Asp Arg Arg Ile Glu Arg His Arg 
                565                 570                 575     


Arg Asp Ala Glu Arg Gln Ala Asp Glu Ala Asn Lys Arg Gly Lys Lys 
            580                 585                 590         


Asn Phe Val Glu Ile Lys Pro Gly Arg Leu Gly Ser Trp Leu Ala His 
        595                 600                 605             


Asp Met Ile Ala Met Gln Pro Gln Pro Arg Gly Gly Glu Asn Lys Leu 
    610                 615                 620                 


Thr Gly Leu Asn Phe Gln Ile Leu Gln Ser Ala Leu Ser Met Phe Asp 
625                 630                 635                 640 


Asn Leu Glu Asn Met Arg Gln Val Leu Ile Ser Ala Arg Leu Ile Gly 
                645                 650                 655     


Ser Ser Tyr Ser His Pro Phe Leu Glu Lys Val Leu Asn Lys Gln Pro 
            660                 665                 670         


Arg Asn Thr Ile Glu Leu Tyr Lys Ile Tyr Leu Asp Glu Lys Val Ala 
        675                 680                 685             


Trp Leu Arg Ser Leu Lys Pro Glu Glu Ile Arg Ala Leu Gly Phe Ile 
    690                 695                 700                 


Thr Arg Gly Thr Asp Lys Trp Ser Ala Arg Asp Glu Glu Tyr Tyr Lys 
705                 710                 715                 720 


Arg Val Leu Leu Arg Tyr Lys Thr Met Pro Val Glu Leu Pro Arg Gly 
                725                 730                 735     


Leu Phe Ser Gln Ala Ile Lys Lys Leu Leu Ser Glu Gln Phe Gly Pro 
            740                 745                 750         


Ser Phe Val Lys Gly Glu Thr Arg Asp Glu Ala Asn Val Ser Phe Leu 
        755                 760                 765             


Val Ser Lys Tyr Phe Arg Asp Lys Cys Asn Asp Asp Ser Gln Glu Phe 
    770                 775                 780                 


Tyr Thr Gln Pro Asn Gly Thr Tyr Lys Arg Tyr Tyr Thr Phe Phe Arg 
785                 790                 795                 800 


Leu Leu Ala Gly Ala Pro Thr Ile Lys Ser Val Pro Glu Tyr Gly Lys 
                805                 810                 815     


Ile Val Thr Glu Ile Asp Ala Phe Leu Lys Ser Asp Pro Ser Leu Asp 
            820                 825                 830         


Leu Leu Leu Thr Lys Gln His Ala Asp Val Ala Thr Ala Gln Pro Thr 
        835                 840                 845             


Phe Asp Leu Ser Arg Glu Ile Glu Glu Val Asn Ile Lys Leu Val Lys 
    850                 855                 860                 


Ala Lys Ala Lys Asn Pro Asn Leu Asp Val Ala Lys Arg Ile Glu Glu 
865                 870                 875                 880 


Ile Ile Ser Ser Ser Met Lys Leu Lys Ser Leu Ser Pro Ala Gln Lys 
                885                 890                 895     


Met Gln Leu Met Ser Lys Phe Leu Gly Lys Asn Val Ala Ser Ala Gln 
            900                 905                 910         


Asn Gln Pro Arg Leu Val Glu Lys Tyr Leu Asn Gly Ile Glu Lys Ser 
        915                 920                 925             


Glu Arg Glu Gln Glu Lys Val Lys Leu Ser Arg Thr Leu Arg Leu Met 
    930                 935                 940                 


Lys Glu Thr Glu Arg Leu Ile Arg Asn Tyr Arg Val Lys Asp Ile Leu 
945                 950                 955                 960 


Leu Phe Leu Met Ala Arg Asn Ile Leu Phe Ala Glu Asp Glu Met Pro 
                965                 970                 975     


Ser Asp Ala Ala Val Lys His Phe Lys Leu Ser Glu Ile Arg Pro Ile 
            980                 985                 990         


Arg Arg Gln Asp Gly Val Gly Thr  Leu Glu Ile Lys Ile  Pro Phe Ser 
        995                 1000                 1005             


Ile Thr  Leu His Ile Lys Gly  Ser Asn Val Pro Val  Arg Ile Thr 
    1010                 1015                 1020             


Gln Asp  Ser Ile Lys Leu Lys  Asn Tyr Gly Asp Phe  Gln Lys Phe 
    1025                 1030                 1035             


Leu Tyr  Asp Thr Arg Leu Glu  Thr Leu Ile Pro Tyr  Leu Val Asp 
    1040                 1045                 1050             


Asp Glu  Asn Ala Val Arg Ile  Asp Val Ser Lys Ala  Glu Leu Asp 
    1055                 1060                 1065             


Asp Glu  Phe Ala Lys Tyr Asp  Thr Ala Arg Ile Glu  Val Phe Ala 
    1070                 1075                 1080             


Asn Val  His Lys Ile Glu Arg  Leu Ile Leu Glu Arg  His Ser Glu 
    1085                 1090                 1095             


Leu Lys  Asp Lys Thr Ser Ala  Ser Tyr Tyr Tyr Gln  Glu Asn Gly 
    1100                 1105                 1110             


Lys Asn  Leu Pro Val Arg Gly  Asn Phe Gly Lys Met  Leu Ser Tyr 
    1115                 1120                 1125             


Asp Lys  Arg Tyr Ala Asp Glu  Asp Gln Ser Glu Met  Val Asn Ile 
    1130                 1135                 1140             


Arg Asn  Ser Phe Ser His Asn  Ser Tyr Arg Gly Asp  Gly Phe Gly 
    1145                 1150                 1155             


Asn Val  Asn Ile Ser Thr Ser  Lys Val Gly Glu Ile  Ala Pro Ala 
    1160                 1165                 1170             


Ile Lys  Gly Lys Leu Lys Asn  Lys Ala Asp Gln Ile  Ser Ala Asp 
    1175                 1180                 1185             


Ala Lys  Lys Asp Asn Val Gln  Asn 
    1190                 1195     


<210>  2696
<211>  1160
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2696

Met Glu Gln Lys Gln Leu Glu Ser Arg Phe Asn Gln Ile Phe Asn Asn 
1               5                   10                  15      


Lys Gly His Thr Gly Pro Ile Ala Glu Lys Ala Val Lys Asn Phe Glu 
            20                  25                  30          


Thr Ile Arg Gln His Lys Val Ser Pro Arg Glu Arg Leu His Tyr Phe 
        35                  40                  45              


Ala Val Gly His Ala Leu Arg Asn Ile Asp Lys Asp Leu Lys Glu Ser 
    50                  55                  60                  


Ile Phe Glu Tyr Asn Leu Asp Glu Glu Gln Lys Lys Gln Lys Pro Thr 
65                  70                  75                  80  


Gln Phe Thr Thr Leu Gln Ser Asp Phe Phe Arg Phe Glu Asn Ala Leu 
                85                  90                  95      


Leu Thr Leu Leu Lys Asp Ile Arg Asn Cys Asn Gly His Tyr Val His 
            100                 105                 110         


Thr Phe Asp Lys Leu Gln Leu Asp Glu Ile Leu Lys Leu Gln Glu Lys 
        115                 120                 125             


Asn Lys Glu His Gly Ile Leu Asn Lys Asp Ala Gly Cys Gln Ile Ile 
    130                 135                 140                 


Glu Phe Leu Lys Glu Ala Phe Glu Phe Ser Ile Leu Ile Gln Phe Leu 
145                 150                 155                 160 


Lys Glu Lys Pro Lys Glu Tyr Glu Lys Phe Lys Lys Arg Lys Asn Glu 
                165                 170                 175     


Asn Lys Asn Gln Ser Leu Arg Asn Leu Ile Gly Gly Tyr Glu Lys Lys 
            180                 185                 190         


Leu Val Lys Tyr Leu Cys Asp Lys Phe Phe Pro Asn Glu Glu Lys Gln 
        195                 200                 205             


Lys Glu Ile Arg Asp Lys Phe Ile Glu His Asn Leu Glu Glu Ala Ile 
    210                 215                 220                 


Glu Asp Leu Leu Phe Ile Pro Val Asp Glu Asp Ile Glu Trp Lys Leu 
225                 230                 235                 240 


Gly Glu Glu His Val Val Phe Val Ile Lys Lys Gly Lys Tyr Leu Ser 
                245                 250                 255     


Phe Tyr Ala Gln Leu Phe Leu Leu Ser Met Phe Leu Tyr Lys Gln Glu 
            260                 265                 270         


Ala Asn Gln Leu Ile Ser Lys Ile Arg Gly Phe Lys Arg Ser Glu Asp 
        275                 280                 285             


Glu Phe Gln Tyr Lys Arg Asn Ile Phe Thr Phe Phe Ser Lys Lys Val 
    290                 295                 300                 


Ser Ser Gln Asp Ile His Ser Glu Glu Lys His Leu Ile Tyr Phe Arg 
305                 310                 315                 320 


Asp Ile Ile Gln Tyr Leu Asn Arg Phe Pro Thr Ala Trp Asn Glu Tyr 
                325                 330                 335     


Leu Ser Pro Glu Arg Lys Asn Leu Pro Met Thr Lys Leu Leu Glu Lys 
            340                 345                 350         


Tyr Ile Leu Glu Glu Glu Ile Phe Arg Thr Phe Ser Thr Tyr Lys Asn 
        355                 360                 365             


Asp Cys Asn Arg Glu Leu Phe Leu Lys Tyr Thr Ile Lys Arg Leu Phe 
    370                 375                 380                 


Arg Lys Lys Ala Glu Leu Phe Asp Ala Glu Lys Ile Ser Ile Asp Asp 
385                 390                 395                 400 


Asn Leu Arg Lys Lys Phe Asn Tyr Glu Ile Asp Thr Ser Pro Glu Leu 
                405                 410                 415     


Lys Asn Ile His Glu Lys Leu Lys Gly Lys Leu Lys Pro Lys Asp Tyr 
            420                 425                 430         


Tyr Lys Asn Ile Lys Arg Lys Glu Glu Leu Glu Lys Glu Glu Asn Pro 
        435                 440                 445             


Glu Lys Leu Lys Leu Ile Lys Lys Val Thr Glu Glu Lys Leu Phe Thr 
    450                 455                 460                 


Ala Tyr Gly Arg Asn Arg Asp Arg Phe Met Asp Phe Ala Val Arg Tyr 
465                 470                 475                 480 


Leu Ala Glu Gln Asn Tyr Phe Gly Lys Asp Ala Glu Phe Lys Met Tyr 
                485                 490                 495     


Met Phe Glu Thr Thr Asn Glu Gln Glu Asn Tyr Leu Lys Glu Gln Lys 
            500                 505                 510         


Asn Thr Ala Asp Lys Lys Val Ile Asp Gln Asn Lys Tyr His Gln Gly 
        515                 520                 525             


Arg Leu Thr Cys Phe Lys Thr Tyr Gln Lys His Lys Asp Asp Tyr Gln 
    530                 535                 540                 


Asn Trp Asp Asp Pro Phe Val Phe Gln Asn Asn Ala Phe Gln Ile Val 
545                 550                 555                 560 


Leu Thr Phe Ser Asn Gly Glu Arg Lys Lys Phe Ser Ile Gln Arg Lys 
                565                 570                 575     


Leu Leu Ile Tyr Leu Leu Glu Asp Ala Leu Phe Asn His Ser Asp Ser 
            580                 585                 590         


Ile Glu Asp Lys Gly Lys Gln Leu Leu Glu Asp Tyr Phe Phe Asn Thr 
        595                 600                 605             


Leu Met Pro Asp Phe Glu Glu Ala Lys Gly Ser Tyr Lys Thr Ser Asp 
    610                 615                 620                 


Asp Val Asn Trp Lys His Arg Lys Leu Leu Pro Lys Arg Leu Ile Tyr 
625                 630                 635                 640 


Thr Val His Pro Pro Arg Arg Thr Asp Ser Glu Glu Gln Ile His Pro 
                645                 650                 655     


Phe Glu Lys Ile Leu Arg Glu Thr Gln Glu Gln Glu Arg Arg Tyr Arg 
            660                 665                 670         


Leu Leu Leu Gly Lys Ala Lys Asn Met Lys Leu Lys Glu Glu Phe Ile 
        675                 680                 685             


Lys Arg Asn Lys Gly Lys His Phe Lys Leu Arg Phe Ile Arg Lys Ala 
    690                 695                 700                 


Trp His Leu Met Tyr Phe Arg Glu Ile Tyr Glu Arg Arg Ala Lys Glu 
705                 710                 715                 720 


His Ser His His Lys Ser Phe His Ile Thr Arg Asp Glu Ile Asn Asp 
                725                 730                 735     


Phe Ser Arg Trp Met Tyr Ala Phe Asp Glu Val Pro Pro Tyr Lys Val 
            740                 745                 750         


Tyr Leu Arg Asn Met Leu Gln Arg Lys Lys Phe Met Glu Asn Glu Glu 
        755                 760                 765             


Phe Ala Glu Leu Phe Glu Lys Gly Lys Ser Leu Asp Glu Phe Tyr His 
    770                 775                 780                 


Leu Thr Lys Gln Glu Phe Ser Lys Arg Ile Lys Asn Asn Leu Phe Gln 
785                 790                 795                 800 


Leu Lys Val Asp Ser Glu Arg Gln Tyr Ala Glu Val Leu Ser Lys Lys 
                805                 810                 815     


Leu Val Tyr Ile Asn Leu Ser His Phe Ile Lys Tyr Leu Asn Ala Lys 
            820                 825                 830         


Gly Lys Leu Thr Val Glu Asn Gly Ile Ile Gln Tyr Lys Ala Ser Thr 
        835                 840                 845             


Asn Lys Lys Tyr Leu Ile Asp Glu Tyr Tyr Tyr Thr Glu Val Leu Pro 
    850                 855                 860                 


Arg Glu Glu Tyr Lys Val His Lys His Leu Phe Asn Lys Leu Arg Ala 
865                 870                 875                 880 


Ala Lys Leu Glu Asp Ala Leu Leu Tyr Glu Leu Ala Met Lys Tyr Leu 
                885                 890                 895     


Lys Glu Asp Glu Glu Ile Val Glu Lys Ala Lys Ser Lys Val Ser Asp 
            900                 905                 910         


Ile Gln Ser Ser Glu Ile Ser Phe Asp Ile Lys Asp Tyr Tyr Gly Asn 
        915                 920                 925             


His Leu Tyr Thr Leu Ile Val Pro Phe Asn Lys Leu Glu Thr Leu Ser 
    930                 935                 940                 


Ile Leu Ile Arg Tyr Lys Thr Gly Gln Glu Asn Glu Leu Lys Asn Lys 
945                 950                 955                 960 


Lys Thr Ser Phe Leu Gly Asn Ile Tyr His Leu Leu Ala Phe Leu Asp 
                965                 970                 975     


Lys Asn Tyr Lys Gln Leu Ser Lys Tyr Lys Asp Asp Gly Gly Phe Lys 
            980                 985                 990         


Lys Ile Val Lys Asn Phe Lys Asn  Lys Lys Arg Leu Ser  Phe Val Glu 
        995                 1000                 1005             


Leu Asn  Thr Ile Asn Gly Tyr  Ile Ile Ser Gly Ala  Val Lys Phe 
    1010                 1015                 1020             


Ser Lys  Val His Met Glu Leu  Glu Arg Tyr Phe Ile  Asn Lys His 
    1025                 1030                 1035             


Lys Ile  Lys Ala Asn His Ile  Tyr Ile Asp Leu Glu  Asp Ile Lys 
    1040                 1045                 1050             


Asp Asp  Ser Asn Lys Gln Val  Phe Gly Asn Tyr Tyr  Asp Ser Lys 
    1055                 1060                 1065             


Leu Arg  Ile Arg Asn Lys Ala  Phe His Phe Gly Val  Pro Thr Asn 
    1070                 1075                 1080             


Phe Phe  Phe Asn Ile Glu Ile  Glu Lys Ile Glu Lys  Lys Phe Ile 
    1085                 1090                 1095             


Leu Glu  Glu Val Lys Leu Gln  Asn Val Ser Ser Phe  Asp Lys Leu 
    1100                 1105                 1110             


Asn Gln  Asn Ala Lys Ser Val  Cys Arg Val Phe Met  Glu Val Leu 
    1115                 1120                 1125             


His Ser  Asp Leu Tyr Arg Arg  Asp Lys Asn Lys Ser  Lys Glu Glu 
    1130                 1135                 1140             


Leu Arg  Arg Glu Phe Glu Glu  Lys Tyr Phe Asn Glu  Ile Ile Thr 
    1145                 1150                 1155             


Thr Val  
    1160 


<210>  2697
<211>  1150
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2697

Met Glu Glu Asn His Asp Ile His Val Asn Ile Val Ala Asp Lys Pro 
1               5                   10                  15      


Phe Ile Ala Gly Tyr Phe Asn Leu Ala Ser Asn His Leu Lys Glu Leu 
            20                  25                  30          


Ser Asp Ala Ile His Ala Arg Phe Pro Asn Leu Lys Asn Ala Ser Asn 
        35                  40                  45              


Phe Leu Ile Pro Thr Pro Val Asn Thr Gly Gln Asn Glu Asp Gln Cys 
    50                  55                  60                  


Val Gln Lys Lys Ile Ser Glu Met Ser Glu Ser Asp Tyr Gln Met Leu 
65                  70                  75                  80  


Leu Asp Leu Val Ser Ser Tyr Phe Arg Ala Val Ser Leu Val Lys Arg 
                85                  90                  95      


Ser Ser Phe Val Asn Gly Val Leu Asp Arg Ile Trp Leu Trp Lys Arg 
            100                 105                 110         


Ile Asn Tyr Ile Leu Ile Leu Gln Asn Ser Leu Arg Asn Tyr Tyr Thr 
        115                 120                 125             


His Tyr Cys His Pro Glu Val Ile Ile Ser Asp Ser Asp Phe Lys Asn 
    130                 135                 140                 


Leu Leu Glu Gln Met Phe Ile Ser Ser Ala Leu Asp Val Lys Glu Lys 
145                 150                 155                 160 


Arg Leu Lys Gly Glu Gln Ala Leu Arg Val Ile Lys Ser Ser Phe Glu 
                165                 170                 175     


Asp Glu Leu Lys Lys Leu Glu Ile Asp Gln Lys Lys Tyr Leu Thr Glu 
            180                 185                 190         


Lys Thr Lys Glu Asn Pro Lys Ile Ser Leu Asp Asp Asp Ser Val Arg 
        195                 200                 205             


Asn Ala Thr Leu Asn His Leu Ile Tyr Arg Met Val Lys Lys Asn Lys 
    210                 215                 220                 


Gln Thr Gly Asp Tyr Glu Ile Asn Lys Gly Tyr Gln Leu Phe Lys Leu 
225                 230                 235                 240 


Val Glu Gly Arg Thr Asp Gln Trp Arg Phe Thr Asp Asp Gly Leu Ala 
                245                 250                 255     


Phe Phe Leu Gly Leu Phe Leu Thr Lys Lys Glu Gly Leu Glu Phe Arg 
            260                 265                 270         


Ser Arg Ile Lys Gly Phe Lys Asp Asn Asn Asn Leu Ser His Asn Val 
        275                 280                 285             


Thr Gln Trp Val Phe Ser Tyr Pro Ala Phe Arg Arg Ala Asp Arg Asn 
    290                 295                 300                 


Phe Thr Thr Val Phe Ser Lys Asp Ala Phe Ile Phe Gln Met Ile Asp 
305                 310                 315                 320 


Glu Leu Asn Lys Val Pro Asp Glu Val Tyr Arg Asn Leu Pro Glu Glu 
                325                 330                 335     


Lys Gln Asp Glu Phe Leu Val Asp Ile Asn Ser Tyr Phe Lys Asp Lys 
            340                 345                 350         


Thr Asp Val Pro Gly Ser Thr Pro Glu Gln Glu Thr Val Val Asn Pro 
        355                 360                 365             


Val Ile Arg Lys Arg Tyr Glu Asp Lys Phe Glu Tyr Phe Ala Leu Arg 
    370                 375                 380                 


Tyr Leu Asp Glu Phe Ala Gly Phe Thr Arg Ile Arg Phe Gln Val Tyr 
385                 390                 395                 400 


Val Gly Asp Tyr Ile His Asp Arg Arg Glu Lys Lys Ile Gly Asn Ser 
                405                 410                 415     


Asn Leu Tyr Thr Glu Arg Glu Cys Arg Glu Lys Val Lys Thr Phe Gly 
            420                 425                 430         


Lys Leu Thr Glu Leu Gln Lys Val Lys Thr Glu Tyr Phe Glu Gly Lys 
        435                 440                 445             


Ala Val Pro Glu Ile Pro Gly Trp Arg Arg Phe Pro Asn Pro Ser Tyr 
    450                 455                 460                 


Arg Ile Glu Asn His Asn Ile Leu Leu Ala Leu Tyr Ile Lys Asn Glu 
465                 470                 475                 480 


Glu Ile Lys Asp Arg Ile Gln Lys Ala Gln Lys Ala Leu Gly Asn Ala 
                485                 490                 495     


Gly Asp Lys Glu Arg Ser Ser Arg Thr Glu Lys Pro Val Arg Gly Glu 
            500                 505                 510         


Met Leu Asn Glu Met Tyr Asn Lys Cys Pro Tyr Lys Phe Asn Ser Thr 
        515                 520                 525             


Pro Phe Ile Ala Gln Met Ser Leu Asn Glu Leu Pro Ala Leu Leu Tyr 
    530                 535                 540                 


Ala Leu Leu Ile Asp His Lys Ser Pro Glu Asp Ile Glu Asp Gln Ile 
545                 550                 555                 560 


Ile Gln Thr Tyr Gln Glu His Phe His Glu Ile Glu Lys Gly Glu Gly 
                565                 570                 575     


Lys His Leu Pro Lys Asn Leu Thr Gln Ser Asp Lys Glu Gly Ala Asp 
            580                 585                 590         


Met Gly Lys Leu Arg Arg Asp Ile Gln Gly Val Ile Asp Asp Ser Asp 
        595                 600                 605             


Glu Arg Leu Leu Ser Phe Asp Lys Leu Lys Arg Glu Lys Ser Lys Gly 
    610                 615                 620                 


Arg Asn Ser Arg Pro Leu Tyr His Val Phe Asp Ser Lys Thr Met Gly 
625                 630                 635                 640 


Glu Thr Val Ser Phe Leu Ala Lys Asp Ile Leu Arg Phe Met Pro Val 
                645                 650                 655     


Ile Tyr Arg Glu Asn Trp Lys Gly Tyr Met His Ser Glu Trp Gln Ala 
            660                 665                 670         


Leu Leu Ser His Tyr Glu Val Asn Arg Gln Ala Ala Ile Asp Leu Leu 
        675                 680                 685             


Phe Ser Cys Trp Lys Thr Gln Asn Ala Pro Glu Ser Thr Gly Met Glu 
    690                 695                 700                 


Ile Leu Asn Leu Phe Gln Lys Ser Glu Thr Phe Glu Glu Leu Tyr Glu 
705                 710                 715                 720 


Glu Tyr Leu Lys Phe Arg Lys Gln Tyr Met Arg Leu Leu Leu Val Gly 
                725                 730                 735     


Leu Gly Ser Ala Asp Ile Gln Met Phe Phe Thr Glu Lys Gly Val Trp 
            740                 745                 750         


Asn Tyr Phe His Lys Arg Leu Tyr Val Arg Asp Pro Thr Ala Thr Leu 
        755                 760                 765             


Thr Asp Arg Leu Leu Ala Arg Pro Ile Val Leu Pro Arg Gly Ile Phe 
    770                 775                 780                 


Asp Lys Lys Pro Thr Tyr Ile Lys Gly Lys Asn Pro Glu Met Asn Arg 
785                 790                 795                 800 


Glu Asp Phe Ala Asp Trp Tyr Val Tyr Pro Tyr Glu Arg Glu Cys Gly 
                805                 810                 815     


Val Gln Met Phe Tyr Gly Tyr Gly Leu Asp Thr Asp Arg Gly Phe Glu 
            820                 825                 830         


Asp Tyr Arg Ile Phe Ser Glu Ser Ile Arg Asp Asn Arg Tyr Asp Trp 
        835                 840                 845             


Ser Glu Glu His Gln Arg Glu Leu Phe Lys Lys Lys Glu Leu Ser Arg 
    850                 855                 860                 


Val Lys Asn Val Lys Arg Lys Asp Ala Phe Leu Tyr Leu Met Val Lys 
865                 870                 875                 880 


Lys Met Leu Glu Asp Glu Gly Val Pro Phe Lys Leu Ser Leu Asn Asp 
                885                 890                 895     


Phe Tyr Leu Pro Gln Glu Ala Ile Ser Lys Arg Lys Gly Val Ala Leu 
            900                 905                 910         


Gly Gln Lys Asn Arg Gln Pro Gly Asp Lys Ser Glu Asn Ile Arg Lys 
        915                 920                 925             


Glu Thr Tyr Ile Trp Asn Met Thr Leu Pro Phe Tyr Tyr Glu Arg Glu 
    930                 935                 940                 


Asp Lys Asn Glu Lys Lys His Lys Val Phe Tyr Glu Glu Lys Val Gln 
945                 950                 955                 960 


Val Lys Asp Leu Arg Thr Leu Ala Ala Arg Met Thr Asn Leu Lys Val 
                965                 970                 975     


Leu Arg Leu Phe Asp Tyr Asp Pro Ser His Leu Trp Asn Arg Lys Ser 
            980                 985                 990         


Leu Glu Ser Glu Leu Ser Asn Tyr  Glu Lys Ile Arg Arg  Glu Asn Leu 
        995                 1000                 1005             


Leu Val  Ile Ile Gln Arg Phe  Glu Arg Glu Val Leu  Leu Arg Tyr 
    1010                 1015                 1020             


Gly Trp  Lys Glu Gly Glu Val  Ala Pro Asp Asp Leu  Leu Ile Thr 
    1025                 1030                 1035             


Asp Lys  Lys Gly Lys Lys Ile  Pro Asn Phe Lys Arg  Tyr Val Phe 
    1040                 1045                 1050             


Ser Ser  Pro Leu Gly Phe Ser  Lys Glu Ala Ile Pro  Gln Leu Leu 
    1055                 1060                 1065             


Asp Asn  Ser Trp Leu Gln Leu  Lys Arg Asn Tyr Pro  Gln Ile Ala 
    1070                 1075                 1080             


Ala Phe  Ser Lys Val Ser Gln  Gly Tyr Gln Leu Ile  Gln Ile Arg 
    1085                 1090                 1095             


Asn Asn  Phe Ala His Asn Lys  Leu Pro Asp Val Ser  Phe Phe Arg 
    1100                 1105                 1110             


Glu Cys  Thr Ala Phe Leu Ala  Lys Asp Pro Ser Glu  Tyr Tyr Ser 
    1115                 1120                 1125             


Gln Tyr  Tyr Phe Arg Leu Ala  Glu Lys Ile Ile Asn  Leu Leu Glu 
    1130                 1135                 1140             


Asn Asn  Ile His Ser Asp Ala  
    1145                 1150 


<210>  2698
<211>  1204
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2698

Met Lys Thr Asn Tyr Gln Asn Phe Cys Ile Lys Ser Phe Phe Gln Ile 
1               5                   10                  15      


Phe Glu Asn Lys Gly Thr Val Gly Ser Val Ala Glu Lys Ala Leu Asn 
            20                  25                  30          


Asn Phe Lys Ser Lys Lys Lys Lys Asn Glu Ser Ile Glu Arg Leu Tyr 
        35                  40                  45              


Tyr Phe Ala Ile Gly His Ala Phe Lys Gln Ile Asp Lys Lys Asn Ile 
    50                  55                  60                  


Phe Gly Leu Asp Glu Asn Asp Glu Gln Lys Asp Leu Val Tyr Thr Lys 
65                  70                  75                  80  


Phe Leu His Leu Leu Lys Pro His Phe Glu Arg Cys Leu Glu Asn Asn 
                85                  90                  95      


Glu Lys Gly Lys Pro Lys Leu Leu Gln Val Ile Glu Asp Ile Arg Asn 
            100                 105                 110         


Gln Asn Ser His Phe Leu His Thr Phe Asp Glu Leu Ser Leu Asp Lys 
        115                 120                 125             


Ile Glu Lys Glu Thr Ile Val Pro Phe Leu Lys Glu Ser Phe Glu Leu 
    130                 135                 140                 


Ala Leu Ile Gln Ser Phe Leu Lys Glu Lys Ile Asp Ser Glu Asn Gln 
145                 150                 155                 160 


Asn Arg Glu Asn Arg Lys Ala Pro Leu Leu Ser Asn Val Glu Lys Glu 
                165                 170                 175     


Glu Ile Leu Lys Lys Ile Ile Glu Lys Asp Gly Asn Asn Glu Leu Phe 
            180                 185                 190         


Ile Asn Phe Ile Lys Arg Ile Phe Phe Gln Ser Leu Tyr Ile Thr Lys 
        195                 200                 205             


Asn Asp Gln Lys Leu Asn Glu Val Gln Lys Ser Glu Lys Asp Phe Ile 
    210                 215                 220                 


Asp Lys Asn Tyr Gln Thr Lys Asp Glu Leu Ile Asp Phe Ile Leu Leu 
225                 230                 235                 240 


Ile Lys Val Glu Asn Glu Phe Thr Trp Glu Leu Asn Gln Lys Gly Ser 
                245                 250                 255     


Gly Lys Pro Asp Asp His Ile His Glu Met Ile Glu Ile Lys Lys Arg 
            260                 265                 270         


Thr Tyr Leu Ser Phe Glu Ala Cys Ile Phe Leu Leu Ser Met Phe Leu 
        275                 280                 285             


Tyr Lys Asn Glu Ala Asn Gln Leu Ile Pro Lys Ile Arg Gly Phe Lys 
    290                 295                 300                 


Lys Asn Lys Thr Asn Glu Asp Lys Ser Lys Arg Asn Val Phe Thr Phe 
305                 310                 315                 320 


Phe Ala Lys Lys Phe Lys Ser Gln Asp Ile Asp Ser Glu Glu Ser Asn 
                325                 330                 335     


Leu Val Arg Phe Arg Asp Ile Ile Gln Tyr Leu Ser Lys Tyr Pro Thr 
            340                 345                 350         


Glu Trp Asn Ala Glu Ile Glu Lys Ile Lys Ser Glu Asn Pro Met Thr 
        355                 360                 365             


Thr His Leu Lys Asn Ala Ile Ile Glu Met Glu Val Ser Arg Cys Phe 
    370                 375                 380                 


Pro Glu Met Ser His Asp Lys Glu Phe Gln Lys Phe Ala Ile Gln Tyr 
385                 390                 395                 400 


Leu Phe Tyr Asn Glu Ile Ile Glu Ser Lys Asn Lys Lys Ile Tyr Leu 
                405                 410                 415     


Asp Ile Ile Asp Lys Asn Asp Glu Val Arg Lys Thr Tyr Tyr Ala Ile 
            420                 425                 430         


Lys Asp Arg Lys Leu Asn Phe Lys Glu Tyr Lys Pro Asn Thr Ser Lys 
        435                 440                 445             


Gly Phe Thr Leu Asn Tyr Val Lys Gln Lys Tyr Phe Asn Tyr Lys Asn 
    450                 455                 460                 


Ile Arg Pro Ile Asp Ile Gln Lys Lys Asn Ile Lys Lys Phe Thr Lys 
465                 470                 475                 480 


Glu Leu Asn Thr Asn Lys Asn Val Leu Lys Leu Lys Asn Arg Ile Glu 
                485                 490                 495     


His Asn Leu Leu Phe Val Ser Tyr Gly Arg Asn Arg Asp Arg Phe Met 
            500                 505                 510         


Gln Tyr Ala Ala Arg Phe Leu Ala Glu Thr Asn Tyr Phe Gly Asn Asp 
        515                 520                 525             


Ala Glu Phe Lys Met Tyr Gln Phe Tyr Thr Thr Asp Glu Gln Asn Ala 
    530                 535                 540                 


Glu Leu Glu Lys Leu Gln Glu Asn Leu Ser Lys Lys Glu Phe Glu Lys 
545                 550                 555                 560 


Leu Lys Phe His Gln Gly Lys Leu Thr His Phe Ser Thr Tyr Ser Lys 
                565                 570                 575     


His Leu Lys Asn Phe Pro Glu Trp Asp Met Pro Phe Val Val Gln Asn 
            580                 585                 590         


Asn Ala Ile His Val Lys Ile Lys Asp Ile Pro Lys Thr Val Cys Ile 
        595                 600                 605             


Gln Arg Asn Leu Met Ile Tyr Phe Leu Glu Asp Ala Leu Phe Lys Lys 
    610                 615                 620                 


Ser Glu Gly Lys Ile Gln Phe Gly Gly Tyr Lys Leu Ile Gly Tyr Tyr 
625                 630                 635                 640 


Asn Gln Leu Lys Glu Glu Lys Gln Ser Ile Leu Gly Asn Leu Lys Asn 
                645                 650                 655     


Asn Thr Pro Asp Asp Glu Asp Asp Glu Gln Lys Ala Glu Tyr Lys Lys 
            660                 665                 670         


Leu Phe Pro Arg Lys Leu Ile Gln Asn Tyr Phe Pro Ala Glu Gln Asn 
        675                 680                 685             


Asn Leu Pro Glu Lys Asn Ser Phe Gln Leu Leu Leu Asp Glu Ala Ile 
    690                 695                 700                 


Gln Ser Glu Gln Arg Tyr Lys Glu Leu Lys Glu Lys Ala Lys Leu Glu 
705                 710                 715                 720 


Arg Asn Leu Glu Phe Phe Glu Asn Lys Asn Lys Gly Lys Asn Phe Lys 
                725                 730                 735     


Leu Lys Phe Ile Arg Lys Ala Cys His Leu Met Tyr Phe Arg Asn Ala 
            740                 745                 750         


Tyr Leu Asp Gln Lys Glu Glu Gln Leu Ala Leu Glu Ile Arg Asn Gly 
        755                 760                 765             


Glu Ser Phe Asp Gly Lys Asn His Glu His Glu Lys Ala His His Lys 
    770                 775                 780                 


Arg Phe His Ile Thr Arg Asp Glu Tyr Lys Asp Phe Ser Lys Trp Met 
785                 790                 795                 800 


Phe Ala Met Asp Ser Val Ser Phe Tyr Lys Glu His Leu Asn Gln Leu 
                805                 810                 815     


Phe Glu Asp Lys Gly Phe Phe Arg Asn Pro Glu Phe Lys Gln Leu Phe 
            820                 825                 830         


Lys Asp Val Asp Ser Leu Asp Lys Met Tyr Phe Arg Thr Lys Glu Lys 
        835                 840                 845             


Phe Lys Glu Trp Leu Lys Thr His Ser Pro Glu Thr Glu Lys Asn Asn 
    850                 855                 860                 


Lys Tyr Asn Leu Glu Ser Tyr Gln Ser Tyr Leu Glu Asn Ser Val Phe 
865                 870                 875                 880 


Tyr Ile Asn Val Ser His Tyr Lys Lys Tyr Leu Glu Asp Lys Lys Leu 
                885                 890                 895     


Ile Glu Thr Glu Asn Gly Arg Tyr Ile Tyr Lys Ser Leu Glu Asn Lys 
            900                 905                 910         


Asn His Leu Ile Glu Ser Tyr Tyr Tyr Lys Pro His Phe Asp Ile Pro 
        915                 920                 925             


Lys Asp Asn Ala His His Arg Glu Tyr Tyr Lys Leu Asn His Arg Leu 
    930                 935                 940                 


Arg Thr Ala Lys His Glu Asp Cys Leu Leu Tyr Glu Met Ala Ile Phe 
945                 950                 955                 960 


Tyr Leu Lys Ala Asp Lys Val Lys Ala Gly Glu Leu Lys Asn Asn Ile 
                965                 970                 975     


Thr Glu Ile Leu Gln Gln Lys Ile Asn Phe Pro Val Glu Asp Val Lys 
            980                 985                 990         


Glu Thr Lys Tyr Glu Ile Glu Val  Pro Phe Lys Glu Ile  Glu Lys Phe 
        995                 1000                 1005             


Leu Gln  Ile Leu Phe Phe Asn  Gln Leu Gln Lys Asn  Ser Tyr Ser 
    1010                 1015                 1020             


Ile Ile  Lys Asn Leu Pro Gly  Tyr Leu Glu Lys Thr  Lys Asn Glu 
    1025                 1030                 1035             


Asp Asp  Ile Lys Glu Ile Phe  Asn His Phe Asn Glu  Tyr Asn Leu 
    1040                 1045                 1050             


Leu Lys  Leu Asp Asp Leu Asn  Lys Val His Asn His  Leu Ile Asn 
    1055                 1060                 1065             


Gln Gln  Ser Lys Phe Thr Pro  Cys Val Met Ala Met  Glu Glu Tyr 
    1070                 1075                 1080             


Phe Ile  Trp Arg His Lys Gln  Asn Leu Lys Glu Leu  Asn Arg Leu 
    1085                 1090                 1095             


Pro Ile  Gly Ser Ile Glu Gly  Leu Lys Asp Tyr Phe  Thr Gly Asp 
    1100                 1105                 1110             


Asp Gln  Pro Leu Arg Gly Asn  Ala Phe His Phe Asn  Leu Pro Asn 
    1115                 1120                 1125             


Lys Ser  Tyr Lys Lys Phe Phe  Glu Gln Leu Glu Asp  Lys Phe Ile 
    1130                 1135                 1140             


Arg Glu  Glu Phe Pro Lys Glu  Lys Ile Glu Asn Phe  Glu Asp Leu 
    1145                 1150                 1155             


Lys Leu  Pro Leu Gln Lys Ile  Phe Gln Val Phe Leu  Asp Gln Met 
    1160                 1165                 1170             


Arg Asn  Asp Glu Asp Lys Asn  Asp Pro Lys Val Lys  Lys Lys Lys 
    1175                 1180                 1185             


Ala Gln  Ala Lys Tyr Leu Lys  Thr Ile His Gln Lys  Lys Lys Asn 
    1190                 1195                 1200             


Gln 
    


<210>  2699
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2699

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Leu Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2700
<211>  1127
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2700

Leu Gln Lys Gln Asp Lys Leu Phe Val Asp Arg Lys Lys Asn Ala Ile 
1               5                   10                  15      


Phe Ala Phe Pro Lys Tyr Ile Thr Ile Met Glu Asn Lys Glu Lys Pro 
            20                  25                  30          


Glu Pro Ile Tyr Tyr Glu Leu Thr Asp Lys His Phe Trp Ala Ala Phe 
        35                  40                  45              


Leu Asn Leu Ala Arg His Asn Val Tyr Thr Thr Val Asn His Ile Asn 
    50                  55                  60                  


Lys Leu Leu Glu Ile Ala Glu Leu Lys Asn Asp Glu Asp Val Leu Asn 
65                  70                  75                  80  


Ile Lys Asp Ser Trp Asn Lys Gln Ala Glu Lys Leu Asp Lys Lys Val 
                85                  90                  95      


Arg Leu Arg Asn Leu Leu Met Arg His Phe Pro Phe Leu Glu Ala Ala 
            100                 105                 110         


Ala Tyr Lys Lys Thr Thr Ser Lys Asp Ser Asn Ser Lys Glu Gln Lys 
        115                 120                 125             


Glu Lys Glu Gln Ala Glu Ala Leu Ser Leu Asp Asn Leu Lys Asn Val 
    130                 135                 140                 


Leu Phe Ile Phe Leu Glu Lys Leu Gln Ser Leu Arg Asn Tyr Tyr Ser 
145                 150                 155                 160 


His Tyr Lys Tyr Ser Glu Glu Ala Gln Lys Pro Thr Phe Glu Asn Asp 
                165                 170                 175     


Leu Leu Lys Asn Met Tyr Lys Ile Phe Asp Thr Asn Val Arg Leu Val 
            180                 185                 190         


Lys Arg Asp Tyr Met His His Glu Asn Val Asp Met Gln Arg Asp Phe 
        195                 200                 205             


Ser His Leu Asn Arg Lys Arg Gln Glu Gly Gln Thr Arg Lys Ile Ile 
    210                 215                 220                 


Ala Asn Pro Asn Phe Arg Tyr His Phe Ala Asp Glu Lys Gly Asp Met 
225                 230                 235                 240 


Thr Ile Ala Gly Leu Leu Phe Phe Ile Ser Leu Phe Leu Asp Lys Lys 
                245                 250                 255     


Asp Ala Ile Trp Met Gln Lys Lys Leu Lys Gly Phe Lys Asp Gly Arg 
            260                 265                 270         


Asn Leu Arg Glu Gln Met Thr Asn Glu Val Phe Cys Arg Ser Arg Ile 
        275                 280                 285             


Ser Leu Pro Lys Leu Lys Leu Glu Asn Val Gln Thr Lys Asp Trp Met 
    290                 295                 300                 


Gln Leu Asp Met Leu Asn Glu Leu Val Arg Cys Pro Lys Ser Leu Tyr 
305                 310                 315                 320 


Glu Arg Leu Arg Glu Lys Asp Arg Glu Ser Phe Lys Val Pro Phe Asp 
                325                 330                 335     


Ile Phe Ser Asp Asp Tyr Asp Ala Glu Glu Glu Pro Phe Lys Asn Thr 
            340                 345                 350         


Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe 
        355                 360                 365             


Asp Leu Asn Glu Ile Phe Glu Gln Leu Arg Phe Gln Ile Asp Leu Gly 
    370                 375                 380                 


Thr Tyr His Phe Ser Ile Tyr Asn Lys Leu Ile Gly Asp Glu Asp Glu 
385                 390                 395                 400 


Val Arg His Leu Thr His His Leu Tyr Gly Phe Ala Arg Ile Gln Asp 
                405                 410                 415     


Phe Ala Pro Gln Asn Gln Pro Glu Glu Trp Arg Lys Leu Val Lys Asp 
            420                 425                 430         


Leu Asp His Phe Glu Thr Ser Gln Lys Pro Tyr Ile Ser Lys Thr Ala 
        435                 440                 445             


Pro His Tyr His Leu Glu Asn Glu Lys Ile Gly Ile Lys Phe Cys Ser 
    450                 455                 460                 


Thr His Asn Lys Leu Phe Pro Ser Leu Lys Arg Glu Lys Thr Cys Asn 
465                 470                 475                 480 


Gly Arg Ser Lys Phe Asn Leu Gly Thr Gln Phe Thr Ala Glu Ala Phe 
                485                 490                 495     


Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu 
            500                 505                 510         


Thr Lys Asp Tyr Ser Arg Lys Glu Ser Ala Asp Lys Val Glu Gly Ile 
        515                 520                 525             


Ile Arg Lys Glu Ile Ser Asn Ile Tyr Ala Ile Tyr Asp Ala Phe Ala 
    530                 535                 540                 


Asn Asn Glu Ile Asn Ser Ile Ala Asp Leu Thr Gly Arg Leu Gln Lys 
545                 550                 555                 560 


Thr Asn Ile Leu Gln Gly His Leu Pro Lys Gln Met Ile Ser Ile Leu 
                565                 570                 575     


Glu Gly Arg Gln Lys Asp Met Glu Lys Glu Ala Glu Arg Lys Ile Gly 
            580                 585                 590         


Glu Met Ile Asp Asp Thr Gln Arg Arg Leu Asp Leu Leu Cys Lys Gln 
        595                 600                 605             


Thr Asn Gln Lys Ile Arg Ile Gly Lys Arg Asn Ala Gly Leu Leu Lys 
    610                 615                 620                 


Ser Gly Lys Ile Ala Asp Trp Leu Val Ser Asp Met Met Arg Phe Gln 
625                 630                 635                 640 


Pro Val Gln Lys Asp Thr Asn Asn Ala Pro Ile Asn Asn Ser Lys Ala 
                645                 650                 655     


Asn Ser Thr Glu Tyr Arg Met Leu Gln His Ala Leu Ala Leu Phe Gly 
            660                 665                 670         


Ser Glu Ser Ser Arg Leu Lys Ala Tyr Phe Arg Gln Met Asn Leu Val 
        675                 680                 685             


Gly Asn Ala Asn Pro His Pro Phe Leu Ala Glu Thr Gln Trp Glu His 
    690                 695                 700                 


Gln Thr Asn Ile Leu Ser Phe Tyr Arg Asn Tyr Leu Glu Ala Arg Lys 
705                 710                 715                 720 


Lys Tyr Leu Lys Gly Leu Lys Pro Gln Asn Trp Lys Gln Tyr Gln His 
                725                 730                 735     


Phe Leu Ile Leu Lys Val Gln Lys Thr Asn Arg Asn Thr Leu Val Thr 
            740                 745                 750         


Gly Trp Lys Asn Ser Phe Asn Leu Pro Arg Gly Ile Phe Thr Gln Pro 
        755                 760                 765             


Ile Arg Glu Trp Phe Glu Lys His Asn Asn Ser Lys Arg Ile Tyr Asp 
    770                 775                 780                 


Gln Ile Leu Ser Phe Asp Arg Val Gly Phe Val Ala Lys Ala Ile Pro 
785                 790                 795                 800 


Leu Tyr Phe Ala Gly Glu Tyr Lys Asp Asn Val Gln Pro Phe Tyr Asp 
                805                 810                 815     


Tyr Pro Phe Asn Ile Gly Asn Lys Leu Lys Pro Gln Lys Gly Gln Phe 
            820                 825                 830         


Leu Asp Lys Lys Glu Arg Val Glu Leu Trp Gln Lys Asn Lys Glu Leu 
        835                 840                 845             


Phe Lys Asn Tyr Pro Pro Glu Lys Arg Lys Thr Asp Leu Ala Tyr Leu 
    850                 855                 860                 


Asp Phe Leu Ser Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys 
865                 870                 875                 880 


Asn Gln Asp Ile Val Thr Trp Leu Met Phe Lys Glu Leu Phe Lys Thr 
                885                 890                 895     


Thr Thr Val Glu Gly Leu Lys Ile Gly Glu Ile His Leu Arg Asp Ile 
            900                 905                 910         


Asp Thr Asn Thr Ala Asn Glu Glu Ser Asn Asn Ile Leu Asn Arg Ile 
        915                 920                 925             


Met Pro Met Lys Leu Pro Val Lys Thr Tyr Glu Thr Asp Asn Lys Gly 
    930                 935                 940                 


Asn Ile Leu Lys Glu Arg Pro Leu Ala Thr Phe Tyr Ile Glu Glu Thr 
945                 950                 955                 960 


Glu Thr Lys Val Leu Lys Gln Gly Asn Phe Lys Val Leu Ala Lys Asp 
                965                 970                 975     


Arg Arg Leu Asn Gly Leu Leu Ser Phe Ala Glu Thr Thr Asp Ile Asp 
            980                 985                 990         


Leu Glu Lys Asn Pro Ile Thr Lys  Leu Ser Val Asp His  Glu Leu Ile 
        995                 1000                 1005             


Lys Tyr  Gln Thr Thr Arg Ile  Ser Ile Phe Glu Met  Thr Leu Gly 
    1010                 1015                 1020             


Leu Glu  Lys Lys Leu Ile Asp  Lys Tyr Ser Thr Leu  Pro Thr Asp 
    1025                 1030                 1035             


Ser Phe  Arg Asn Met Leu Glu  Arg Trp Leu Gln Cys  Lys Ala Asn 
    1040                 1045                 1050             


Arg Pro  Glu Leu Lys Asn Tyr  Val Asn Ser Leu Ile  Ala Val Arg 
    1055                 1060                 1065             


Asn Ala  Phe Ser His Asn Gln  Tyr Pro Met Tyr Asp  Ala Thr Leu 
    1070                 1075                 1080             


Phe Ala  Glu Val Lys Lys Phe  Thr Leu Phe Pro Ser  Val Asp Thr 
    1085                 1090                 1095             


Lys Lys  Ile Glu Leu Asn Ile  Ala Pro Gln Leu Leu  Glu Ile Val 
    1100                 1105                 1110             


Gly Lys  Ala Ile Lys Glu Ile  Glu Lys Ser Glu Asn  Lys Asn 
    1115                 1120                 1125         


<210>  2701
<211>  1131
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2701

Met Glu Lys Thr Ile Glu Asn Gln Thr Gln Ser Lys Arg Thr Leu Asn 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Asp Glu Glu Lys Ile Thr Thr Ser Phe Leu Val Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Arg Gln Ser Leu Val Tyr Ser Asn Leu Thr 
65                  70                  75                  80  


Arg Tyr Met His Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Asp 
                85                  90                  95      


Asp Glu Arg Asp Lys Ala Glu Asn Tyr Gly Lys Asp Phe Gly Asn Leu 
            100                 105                 110         


Thr Asp Thr Leu Lys Glu Ile Phe Lys Glu Leu Asn Glu Phe Arg Asn 
        115                 120                 125             


Asp Tyr Ser His Tyr Tyr Ser Thr Glu Lys Lys Asp Lys Arg Lys Thr 
    130                 135                 140                 


Ile Val Ser Asp Lys Leu Lys Asn Phe Leu Asn Ile Asn Tyr Thr Arg 
145                 150                 155                 160 


Ala Ile Lys Tyr Thr Lys Ser Arg Phe Ile Asn Val Phe Ser Asp Asn 
                165                 170                 175     


Asn Phe Cys Leu Ala Glu Glu Ala Lys His Val Glu Asn Asp Asn Thr 
            180                 185                 190         


Ile Thr Gln Asp Gly Ile Val Phe Phe Thr Ser Met Phe Leu Asp Arg 
        195                 200                 205             


Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile Ile Gly Leu Lys Gly Thr 
    210                 215                 220                 


Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Thr Leu Met Ala Phe Cys 
225                 230                 235                 240 


Val Asn Leu Pro His Asp Lys Phe Val Ser Glu Asn Ser Glu Gln Gln 
                245                 250                 255     


Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu 
            260                 265                 270         


Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln His Phe Leu Pro Lys Leu 
        275                 280                 285             


Asp Asp Glu Gln Ile Asp Asn Val Leu Glu Asn Ser Val Pro Tyr Thr 
    290                 295                 300                 


Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn Ile Thr Lys Lys Val Arg 
305                 310                 315                 320 


Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu Lys Phe Ile Asp Gln Lys 
                325                 330                 335     


Lys Leu Phe Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val 
            340                 345                 350         


Leu Asp Glu Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Lys Arg Thr 
        355                 360                 365             


Val Thr Glu Asn Thr Lys Ala Phe Gly Met Leu Gln Asp Leu Asn Asp 
    370                 375                 380                 


Glu Glu Asn Val Leu Asn Lys Ile Asn Thr Gly Glu Ser Lys Ala Lys 
385                 390                 395                 400 


Phe Asp Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Thr Lys Asn 
            420                 425                 430         


Thr Asp Asn Lys Ile Lys Ser Asn Leu Leu Gln Pro Leu Pro Glu Ala 
        435                 440                 445             


Phe Leu Ser Ile Asn Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
    450                 455                 460                 


Glu Gln Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn 
465                 470                 475                 480 


Asn Ser Lys Ile Leu Asn Lys Glu Phe Ile Lys Ala Ile Lys Leu Lys 
                485                 490                 495     


Leu Asn Asp Leu Asp Val Phe Tyr Lys Arg Ser Gln Gly Arg Lys Gln 
            500                 505                 510         


Lys His Ala Tyr Leu Thr Lys Asp Lys Lys Tyr Asp Asn Glu Lys Ile 
        515                 520                 525             


Asn Glu Leu Lys Asn Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu 
    530                 535                 540                 


Tyr Asn Leu Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp 
545                 550                 555                 560 


Leu Asn Ile Ala Asp Val Gln Ala Lys Asn Ala Ile Ser Asp Arg Ile 
                565                 570                 575     


Lys Leu Met Lys Arg Asp Cys Ile Asn Arg Leu Lys Ser Met Lys Lys 
            580                 585                 590         


Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp 
        595                 600                 605             


Ile Val Asp Met Ile Ile Asp Glu Glu Lys Lys Lys Lys Ile Thr Ser 
    610                 615                 620                 


Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Lys 
625                 630                 635                 640 


Glu Lys Lys Glu Leu Phe Ile Leu Ile Cys Asn Asn Glu Leu Lys Leu 
                645                 650                 655     


Asn Asp Asp Asp Gly His Pro Phe Phe Lys Asn Ile Asn Phe Ser Asn 
            660                 665                 670         


Tyr Lys Tyr Thr Ser Glu Ile Tyr Gln Lys Tyr Leu Glu Glu Lys Gly 
        675                 680                 685             


His Lys Met Val Lys Glu Tyr Asn Pro Arg Lys Glu Asn Tyr Val Glu 
    690                 695                 700                 


Lys Asp Lys Ser Trp Leu Glu Ile Asn Phe Tyr Lys Lys Glu Trp Asn 
705                 710                 715                 720 


Glu Asn Ala Lys Lys Asp Leu Thr Val Val Lys Leu Pro Asp Asp Lys 
                725                 730                 735     


Ser Lys Ile Pro Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser 
            740                 745                 750         


Phe Glu Asn Trp Phe Lys Tyr Val Thr Asn Gly Lys Glu Thr Thr Asp 
        755                 760                 765             


Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp Glu Thr Leu 
    770                 775                 780                 


Lys Glu Leu Leu Lys Lys Glu Leu Ser Lys Asn Asn Ile Glu Phe Lys 
785                 790                 795                 800 


Glu Glu Asp Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Asp Lys Cys 
                805                 810                 815     


Arg Asn Asp Lys Thr Gln Lys Phe Tyr Ser Ala Glu Arg Glu Tyr Thr 
            820                 825                 830         


Phe Glu Glu Glu Lys Leu Asn Phe His Ile Asn Thr Lys Ser Lys Phe 
        835                 840                 845             


Glu Glu Tyr Ile Asn Pro Glu Phe Ala Glu Lys Val Phe Arg Leu Lys 
    850                 855                 860                 


Asn Gln Asn Arg Glu Lys Asp Asn Ile Ser Gly Arg Arg Leu Pro Pro 
865                 870                 875                 880 


Leu Lys Met Lys Glu Val Thr Lys Asn Met Val Lys Arg Ile Gly Asn 
                885                 890                 895     


Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Leu Met Leu 
            900                 905                 910         


Leu Met Phe Glu Lys Leu Val Asp Asn Asn Leu Lys Leu Lys Leu Glu 
        915                 920                 925             


Asn Val Asp Lys Leu Leu Asn Glu Ser Ile Glu Ile Asn Gln Ser Ile 
    930                 935                 940                 


Ser Gly Lys Leu Ser Phe Asp Asp Ser Gly Asp Asn Glu Asn Lys Lys 
945                 950                 955                 960 


Asp Arg Ala Ile Ile Cys Arg Asn Ile Thr Glu Thr Arg Lys Arg Lys 
                965                 970                 975     


Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Glu Glu Glu  Asn Ile Pro Ile Glu  Lys Ile Lys 
        995                 1000                 1005             


Ile Glu  Leu Asp Thr Tyr Ser  Lys Ala Lys Asp Val  Val Phe Asp 
    1010                 1015                 1020             


Leu Ile  Phe Asp Leu Glu Arg  Ala Ile Ile Asn Lys  Asp Glu Asn 
    1025                 1030                 1035             


Arg Ile  Lys Glu Leu Asn Lys  Asp Lys Asn Gly Val  Ile Gln Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Phe Trp Leu  Leu Glu Lys 
    1055                 1060                 1065             


Asn Leu  Ile Thr Glu Gln Glu  Phe Thr Phe Met Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Thr  Phe Ser His Asn Gln  Phe Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Leu Phe  Ile Lys Asn Trp Asn  Glu Asn Glu Phe Ala  Lys Gln Ile 
    1100                 1105                 1110             


Leu Asn  Val Tyr Asn Gln Lys  Asn Asn Asn Leu Ile  Lys Ser Ile 
    1115                 1120                 1125             


Lys Asp  Ile 
    1130     


<210>  2702
<211>  1158
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2702

Met Lys Thr Thr Thr Asp His Arg Val Ile Ile Phe Asn Asp Lys Arg 
1               5                   10                  15      


Gln Thr Phe Asn Leu Asp Tyr Ala His Ile Ile Gly Ser Tyr Ser Ala 
            20                  25                  30          


Leu Ala Arg Asn Asn Ile Phe Thr Gln Phe Ile Ile Ile Glu Glu Arg 
        35                  40                  45              


Leu Val Arg Asn Gly Gln Leu Arg Lys Ile Thr Leu Thr Asn Asp Ile 
    50                  55                  60                  


Asp Phe His Ser Cys Gly Leu Val Ser Glu Leu Ile Ala Gly Thr Asp 
65                  70                  75                  80  


Pro Ser Ile Lys Ser Tyr Leu Tyr Gly Ser Gly Asp Pro Gln Arg Lys 
                85                  90                  95      


Ile Ile Ile Tyr Glu His Leu Leu Arg Ala Phe Pro Trp Thr Lys Ile 
            100                 105                 110         


Phe Val Thr Glu Val Lys Asp Asn Glu Ala Met Val Glu Glu Tyr Tyr 
        115                 120                 125             


Asn Arg Leu Arg Gly Phe Leu Arg Phe Leu Asp Glu Cys Arg His Tyr 
    130                 135                 140                 


Gly Val His Ser Gln His Asp Pro Pro Glu Ile Leu Lys Gly Tyr Asp 
145                 150                 155                 160 


Val Lys Leu Leu Glu Phe Leu Tyr Asp Gln Ala Tyr His Gly Val Lys 
                165                 170                 175     


Glu Arg Phe Gly Leu Asp Lys Asn Met Ile Asp His Glu Asn Ile Leu 
            180                 185                 190         


Gly His Leu Val Arg Lys Asn Asn Asn Gly Leu Ile Pro Ser Cys Arg 
        195                 200                 205             


Tyr Gln Leu Arg Cys Ile Gly Gly Arg Asp Ile Glu Thr Lys Met Met 
    210                 215                 220                 


Ile Ser Arg Ala Gly Ile Ile Phe Phe Leu Gly Leu Trp Leu Thr Lys 
225                 230                 235                 240 


Glu Gln Ser Val Asn Trp Leu Lys Gln His Ser Gly Tyr Lys Gly Met 
                245                 250                 255     


Arg Pro Asp Ala Lys Thr Gly Met Asn Thr Lys Val Asp Gly Leu Asn 
            260                 265                 270         


Lys Glu Arg Ala Thr Ile Glu Leu Phe Cys Tyr His Asn Ile Arg Leu 
        275                 280                 285             


Pro Lys Pro Leu Ile Glu Pro Gln Lys Asp Thr Val Gln Phe Phe Leu 
    290                 295                 300                 


Asp Met Ile Asn Glu Leu His Arg Cys Pro Arg Glu Leu Tyr Asp Arg 
305                 310                 315                 320 


Leu Asp Asn Asp Asn Lys Leu Leu Phe Met Ser Thr Phe Glu Gly Leu 
                325                 330                 335     


Asp Asn Phe Asp Ile Lys Glu Tyr Lys Asp Tyr Asn Ser Ile Val Lys 
            340                 345                 350         


Leu Val Arg Tyr Lys Asn Arg Phe Ala Ile His Ala Ile Arg Phe Leu 
        355                 360                 365             


Asp Tyr Asn Lys Leu Leu Gly Ser Tyr Asp Phe His Ile Asn Leu Gly 
    370                 375                 380                 


Lys Tyr Val Phe Val Gln Lys Glu Lys Asn Tyr Lys Glu Gly Ser Gln 
385                 390                 395                 400 


Val Arg Phe Leu Asp Gln Lys Val Leu Arg Phe Gly Asn Pro Gln Asp 
                405                 410                 415     


Tyr Asp Gln Asn Phe Lys Arg Lys Ile Ala Pro Val Tyr Gln Ile Glu 
            420                 425                 430         


His Glu Gly Ala Glu Pro Glu Glu Gly Val Ser Leu Ile Ala Asp Gln 
        435                 440                 445             


Ser Ser Leu Thr Val Pro Tyr Trp Met Tyr Ala Asn Thr His Tyr His 
    450                 455                 460                 


Tyr Ser Gly Asn Gln Ile Ala Ile Arg Lys Lys Ile Ala Asp Asn Ala 
465                 470                 475                 480 


Lys Asn Met Ala Phe Glu Lys Leu Glu Asn Tyr Ser Leu Pro Gln Val 
                485                 490                 495     


Pro Ala Thr Ala Leu Leu Pro Phe Asp Ala Phe Pro Val Leu Val Phe 
            500                 505                 510         


Tyr Ser Ile Leu Leu Lys Asp Phe Asn Asn Asp Lys Pro Ser Leu Glu 
        515                 520                 525             


Asp Ile Ile Asp Asp Phe Ile Leu Ser Phe Glu Arg Leu Val Glu Leu 
    530                 535                 540                 


Ile Glu Ser Asp Ala Phe Ser Thr Asn Leu Ile Gly Leu Ser Glu Lys 
545                 550                 555                 560 


Leu Thr Pro Tyr Lys Ala Asp Ile Ala Ile Tyr Arg Lys Glu Lys Gly 
                565                 570                 575     


Lys Glu Ile Ser Ser Trp Leu Arg Thr Lys Gly Leu Gln His Arg Tyr 
            580                 585                 590         


Gly Ile Ile Pro Arg Gln Leu Arg Met Tyr Phe Asp Ile Asp Lys Val 
        595                 600                 605             


Gly Lys Gly Glu Glu Glu Leu Cys Arg Met Met Ile Gln Lys Glu Ile 
    610                 615                 620                 


Glu Ala Thr Gln Lys Trp Ile Asp Gly Ile Lys Lys Ala Glu Asn Asn 
625                 630                 635                 640 


Leu Ser Arg Ile Lys Asn Val Thr Gln Arg Thr Ile Glu Tyr Lys Lys 
                645                 650                 655     


Glu Lys Tyr Leu Asn Ser Gly Gln Thr Ala Thr Ser Leu Ile Lys Asp 
            660                 665                 670         


Ile Ile Lys Tyr Val Pro Ala Leu Ile Asn Lys Glu Asp Gly Lys Val 
        675                 680                 685             


Arg Asn Lys Pro Asn Ser Leu Gln Tyr Asp Met Met Gln Lys Glu Leu 
    690                 695                 700                 


Ala Tyr Phe Ser Ile Ser Lys Pro Asp Leu Ile Lys Ser Phe Glu Glu 
705                 710                 715                 720 


Phe Gly Ile Ile Gly Gly Pro Ser Pro His Pro Phe Val Ser Thr Gly 
                725                 730                 735     


Leu Val Lys Glu Ser Glu His Asn Ile Gly Phe Cys Lys Asn Tyr Leu 
            740                 745                 750         


Arg Glu Lys Leu Asp Tyr Leu Ser Ile Cys Gln Ser Glu Lys Asn Tyr 
        755                 760                 765             


Ser Ser Tyr Tyr Phe Leu Arg Arg Ala Phe Lys Lys Arg Gly Ser Glu 
    770                 775                 780                 


Gln Phe Ile Ser Ala Ile Lys Glu Asn Gly Phe Ser Val Gly Ile Pro 
785                 790                 795                 800 


Lys Ala Tyr Phe Cys Met Arg Leu Lys Gln Leu Ile Ser Arg Pro Ser 
                805                 810                 815     


Asn Val Glu Lys Leu Asn Gly Trp Glu Tyr Leu Glu Asp Cys Ile Ser 
            820                 825                 830         


Asp Ala Thr Asn Asn Glu Asn Lys Leu Arg Ser Ser Arg Leu Val Lys 
        835                 840                 845             


Ser Leu Ser Ser Phe Tyr Phe Asn Gln Asn Pro Gln Glu Phe Tyr Glu 
    850                 855                 860                 


Tyr Asn Arg Thr Tyr Ser Ala Val Asn Glu Leu Lys Asn Arg Ser Ala 
865                 870                 875                 880 


Lys Tyr Asn Lys Lys Asn Tyr Tyr Val Ser Gln Glu Glu Phe Arg Asp 
                885                 890                 895     


Met Ser Val Gln His Arg Val Ala Met Glu Ser Gly Ser Lys Glu Lys 
            900                 905                 910         


Cys Leu Trp Ser Lys Gly Asn Arg Gln Asp Ala Arg Ile Arg Gln Leu 
        915                 920                 925             


Glu Leu Asn Asp Gln Val Leu Ile Leu Met Ala Arg Ala Gln Leu Gln 
    930                 935                 940                 


Glu Asn Asp His Ala Leu Phe Glu Arg Leu Lys Asn Asp Phe Leu Leu 
945                 950                 955                 960 


Gln Asn Val Arg Lys Glu Gly Ser Val Asn Val Phe Thr Gln Glu Phe 
                965                 970                 975     


Asn Ala Glu Ile Glu Ile Pro His Lys Gly Gln Ser Ser Gly Phe His 
            980                 985                 990         


Phe Tyr Ile Thr Gly Asp Val Asn  Leu Lys Asn Ala Gly  Phe Phe Phe 
        995                 1000                 1005             


Ala Leu  Arg Lys Asn Arg Leu  Val Ile Ser Leu Gly  Ile Ala Leu 
    1010                 1015                 1020             


Ser Ser  Leu Tyr Gly Ser Val  Thr Ile Lys Met Asn  Tyr Gln Asp 
    1025                 1030                 1035             


Leu Met  Asn Glu Leu Lys Arg  Phe Glu Ser Val Arg  Ile Asp Gly 
    1040                 1045                 1050             


Ile Lys  Ile Ile Arg Glu Phe  Glu Lys Ser Ile Tyr  Asn Gln Asn 
    1055                 1060                 1065             


Pro Ala  Phe Phe Asp Lys Asp  Asn Leu Leu Asn Ser  His Asn Ala 
    1070                 1075                 1080             


Tyr Leu  Glu Tyr Leu Val Ala  Glu Asp Lys Leu Ser  Glu Asp Asp 
    1085                 1090                 1095             


Lys Lys  Ala Met Asn Leu Phe  Arg Asn Cys Ile Met  His Asn Gln 
    1100                 1105                 1110             


Tyr Lys  Ser Met Lys Pro Asp  Trp Leu Asn Val Ile  Ser Ser Tyr 
    1115                 1120                 1125             


Asp Glu  Arg Gly Phe Val Ser  His Gly Ser Val Ser  Ile Leu Leu 
    1130                 1135                 1140             


Arg Ser  Leu Leu Glu Ile Leu  Tyr Gly Arg Phe Val  Lys Leu Ser 
    1145                 1150                 1155             


<210>  2703
<211>  1116
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2703

Met Glu Asn Thr Ile Glu Ile Gln Lys Gln Ser Ile Arg Thr Leu Asn 
1               5                   10                  15      


Asn Ala Pro Gln Tyr Phe Gly Leu Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn Tyr Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Glu Glu Glu Lys Ile Thr Ile Ser Phe Leu Gly Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Lys Gln Ser Tyr Ile Tyr Phe Asn Leu Ile 
65                  70                  75                  80  


Lys Tyr Met Pro Val Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Lys 
                85                  90                  95      


Asn Glu Ile Asp Lys Thr Lys Asn Asn Ser Gly Lys Asp Phe Asn Lys 
            100                 105                 110         


Leu Ser Asp Thr Leu Lys Val Ile Phe Lys Glu Leu Asn Glu Phe Arg 
        115                 120                 125             


Asn Asp Tyr Ser His Tyr Phe Ser Thr Glu Lys Gln Asp Lys Arg Lys 
    130                 135                 140                 


Leu Lys Ile Ser Ser Glu Leu Lys Asp Phe Leu Asn Ile Asn Phe Ser 
145                 150                 155                 160 


Arg Ala Leu Ser Tyr Thr Lys Asn Arg Leu Lys Asp Val Phe Ser Asp 
                165                 170                 175     


Asp Asp Phe Asn Ile Ala Ser Gln Thr Val Val Val Asn Asn Asp Asn 
            180                 185                 190         


Thr Ile Thr Gln Asp Gly Ile Val Phe Leu Ile Ser Met Phe Leu Asp 
        195                 200                 205             


Met Glu Asn Ala Phe Gln Phe Ile Asn Lys Ile Ile Gly Leu Lys Gly 
    210                 215                 220                 


Thr Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Val Leu Met Thr Phe 
225                 230                 235                 240 


Cys Val Lys Leu Pro His Asp Lys Phe Val Ser Glu Asn Pro Gln Gln 
                245                 250                 255     


Thr Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Leu 
            260                 265                 270         


Leu Tyr Asn Val Ile Thr Glu Glu Glu Lys Gln Ile Phe Lys Pro Gln 
        275                 280                 285             


Ile Gln Thr Glu Gln Ile Glu Asn Ile Ile Ser Asn Ser Val Pro Asp 
    290                 295                 300                 


Thr Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Ser Ile Thr Lys Lys Val 
305                 310                 315                 320 


Arg Tyr Glu Asn Arg Phe Ser Tyr Phe Ala Leu Lys Tyr Ile Asp Leu 
                325                 330                 335     


Lys Glu Leu Phe Lys Lys Trp Arg Phe Gln Ile Asp Leu Gly Lys Val 
            340                 345                 350         


Val Leu Asp Lys Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Val Arg 
        355                 360                 365             


Thr Val Thr Glu Asn Ala Lys Ala Phe Gly Arg Leu Gln Asp Phe Tyr 
    370                 375                 380                 


Asp Gln Glu Lys Ile Leu Asn Lys Ile Asn Ile Gly Glu Asn Lys Thr 
385                 390                 395                 400 


Arg Phe Tyr Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn 
                405                 410                 415     


Lys Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Ser Lys 
            420                 425                 430         


Asn Thr Thr His Lys Val Lys Phe Asn Leu Leu Gln Pro Leu Pro Glu 
        435                 440                 445             


Val Phe Leu Ser Ile His Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr 
    450                 455                 460                 


Leu Glu Gln Gly Lys Thr Glu Lys Leu Ile Asn Asn Phe Ile Lys Leu 
465                 470                 475                 480 


Ser Asn Ser Thr Ile Leu Asn Lys Lys Phe Ile Glu Thr Ile Lys Tyr 
                485                 490                 495     


Lys Leu Ser Asp Leu Asp Val Phe His Lys Arg Ser Met Gly Arg Lys 
            500                 505                 510         


Glu Ile Ser Ala Tyr Arg Lys Asp Ile Leu Lys Tyr Leu Ile Ala Arg 
        515                 520                 525             


Lys Glu Lys Leu Asn Gln Ile Leu Ser Glu His Asn Leu Ser Val Lys 
    530                 535                 540                 


Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp Leu Asn Ile Ala Asp Val 
545                 550                 555                 560 


Gln Glu Lys Thr Ala Ile Ser Asp Arg Ile Lys Leu Met Lys Arg Asp 
                565                 570                 575     


Cys Met Asp Arg Leu Lys Ala Ile Lys Lys Asn Asn Ala Pro Lys Ile 
            580                 585                 590         


Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile Val Asp Met Leu Ile 
        595                 600                 605             


Ser Glu Gly Lys Lys Lys Lys Ile Thr Ser Phe Tyr Tyr Asp Lys Met 
    610                 615                 620                 


Gln Glu Cys Leu Val Leu Phe Ala Asp Lys Glu Lys Lys Glu Leu Phe 
625                 630                 635                 640 


Ile Ser Ile Cys Ser Glu Leu Lys Leu Asn Asp Ala Asp Gly His Pro 
                645                 650                 655     


Phe Leu Lys Asn Ile Asn Leu Ser Asp Ile Arg Tyr Thr Ser Asp Leu 
            660                 665                 670         


Tyr Lys Ile Tyr Leu Gln Glu Lys Ala Asp Asn Arg Asn Gln Arg Asn 
        675                 680                 685             


Arg Thr Asp Thr Ser Trp Leu Ala Lys Asn Phe Tyr Thr Leu Lys Asn 
    690                 695                 700                 


Val Glu Val Phe Asp Lys Lys Gln Gln Arg Lys Ile Phe Lys Leu Gln 
705                 710                 715                 720 


Thr Ile Val Glu Leu Pro Gln Asp Lys Ser Lys Ile Pro Phe Thr Ile 
                725                 730                 735     


Arg Gln Leu Glu Lys Glu Lys Ser Ser Phe Asn Lys Trp Leu Glu Tyr 
            740                 745                 750         


Ile Thr Lys Gly Lys Glu Thr Thr Asp Lys Lys Lys Pro Val Asn Leu 
        755                 760                 765             


Pro Ala Asn Leu Phe Asp Asp Thr Leu Lys Lys Leu Leu Lys Thr Glu 
    770                 775                 780                 


Leu Ser Lys Asn Asn Ile Gln Tyr Asn Lys Glu Ala Asn Tyr Asn Gln 
785                 790                 795                 800 


Leu Phe Lys Ile Trp Trp Lys Glu Phe Arg Lys Asp Asn Thr Gln Asn 
                805                 810                 815     


Phe Tyr Thr Ala Glu Arg Glu Tyr Thr Phe Glu Glu Glu Lys Leu Asn 
            820                 825                 830         


Phe Lys Ile Asn Thr Gln Pro Lys Phe Glu Asn Tyr Tyr Thr Arg Phe 
        835                 840                 845             


Ala Glu Asn Val Phe Asn Lys Lys Gln Ala Leu Arg Asn Glu Glu Arg 
    850                 855                 860                 


Lys Thr Lys Arg Asn Leu Pro Pro Ile Gln Lys Ile His Val Ile Lys 
865                 870                 875                 880 


Lys Ile Arg Asn Lys Ile Gly Asn Thr Glu Lys Glu Ile Arg Met Leu 
                885                 890                 895     


Gln Glu Glu Asp Arg Leu Met Leu Leu Met Phe Glu Lys Leu Thr Lys 
            900                 905                 910         


Glu Asn Leu Asn Leu Lys Leu Glu Lys Val Asn Glu Leu Leu Asn Glu 
        915                 920                 925             


Arg Ile Glu Ile Lys Glu Lys Ile Pro Gly Lys Leu Ser Phe Asp Asp 
    930                 935                 940                 


Leu Gly Glu Lys Thr Ile Thr Arg Asn Ile Val Glu Thr Arg Lys Arg 
945                 950                 955                 960 


Lys Glu Tyr Ser Val Leu Gln Lys Tyr Ile Phe Asp Arg Arg Leu Pro 
                965                 970                 975     


Glu Leu Phe Glu Tyr Phe Asn Glu Thr Asp Ile Leu Ile Glu Lys Ile 
            980                 985                 990         


Lys Thr Glu Leu Asp Ala Tyr Asn  Lys Ala Lys Asp Ile  Val Phe Asp 
        995                 1000                 1005             


Leu Ile  Phe Lys Leu Glu Glu  Ala Ile Ile Lys Lys  Asp Glu Thr 
    1010                 1015                 1020             


Gly Ile  Lys Glu Leu Asn Lys  Asp Gln Asn Gly Asn  Ile Gln Thr 
    1025                 1030                 1035             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu His Trp Leu  Leu Lys Lys 
    1040                 1045                 1050             


Asn Met  Ile Thr Glu Lys Glu  Phe Thr Phe Ile Asn  Met Val Arg 
    1055                 1060                 1065             


Asn Thr  Phe Ser His Asn Arg  Phe Pro Gln Lys Lys  Thr Met Glu 
    1070                 1075                 1080             


Leu Phe  Ile Lys Lys Trp Asn  Asp Asn Asn Phe Ala  Tyr Gln Ile 
    1085                 1090                 1095             


Leu Glu  Thr Tyr Lys Gln Lys  Thr Asn Asn Ile Ile  Glu Lys Leu 
    1100                 1105                 1110             


Lys Asp  Met 
    1115     


<210>  2704
<211>  1141
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2704

Met Ala Gln Thr Arg Trp Lys Gln Ser Lys Thr Pro Ala Ile Lys Pro 
1               5                   10                  15      


Val Met Ala Ala Tyr Leu Asn Met Ala Arg His Asn Met Tyr Arg Val 
            20                  25                  30          


Met Leu His Ile Ser Arg Gln Met Gln Ile Ile Glu Asn Lys Glu Glu 
        35                  40                  45              


Ala Glu Ile Ala Ala Phe Ser Val Trp Gln Lys Leu Ser Ser Gly Thr 
    50                  55                  60                  


Pro Thr Glu Gln Met Lys Met Ile Lys Leu Leu Gln Arg His Phe Pro 
65                  70                  75                  80  


Val Leu Lys Pro Val Phe Asp Val Glu Lys Lys Lys Asn Val Glu Asn 
                85                  90                  95      


Ala Ala Ile Ser Ala Ser Pro Lys Glu Ile Lys Arg Ile Phe Thr Thr 
            100                 105                 110         


Ile Leu Thr Ala Leu Asn Arg Leu Arg Asn Glu Tyr Ser His Tyr Ser 
        115                 120                 125             


Pro Val Pro Arg Lys Thr Glu Gly Glu Glu Lys Met Ile Ala Tyr Leu 
    130                 135                 140                 


Tyr Arg Cys Met Asp Gly Ser Ala Arg Glu Val Arg Asn Arg Phe Ser 
145                 150                 155                 160 


Leu Thr Val Lys Asp Pro Lys Gly Ala Lys Glu Thr Ala Lys Val Leu 
                165                 170                 175     


Glu Val Asn Lys Ala Val Phe Asp Ile Phe Gln Asp Ala Phe Arg Lys 
            180                 185                 190         


Glu Lys Val Lys Ala Leu Asp Lys Ser Gly Lys Val Ile Lys Asp Asn 
        195                 200                 205             


Lys Gly Arg Thr Gln Phe Glu Phe Arg Asp Lys Glu Asp Tyr Tyr Tyr 
    210                 215                 220                 


Ala Leu Lys Asp Ala Asn Ala Ala Leu Ser Asp Met Gly Ile Val Phe 
225                 230                 235                 240 


Phe Thr Cys Leu Phe Leu Glu Lys Arg Tyr Ala Ala Met Phe Leu Asp 
                245                 250                 255     


Ala Ile Lys Pro Trp Pro Gln Asp Phe Asn Glu Ile Glu Arg Lys Ala 
            260                 265                 270         


Val Leu Glu Val Phe Thr Val Tyr His Ile His Leu Pro Lys Glu Lys 
        275                 280                 285             


Tyr Asp Ser Thr Arg Pro Glu Tyr Ala Leu Gly Leu Asp Met Leu Asn 
    290                 295                 300                 


Glu Leu Gln Lys Cys Pro Lys Glu Leu Phe Asp Ile Leu Ser Ala Lys 
305                 310                 315                 320 


Ser Arg Asp Ala Leu Ser Val Asp Ile Lys Ala Asp Arg Pro Asp Val 
                325                 330                 335     


Val Thr Asp Asp Gly Val Thr Val Lys Asp Gly Lys Val Gln Met Arg 
            340                 345                 350         


Arg Val Arg Asp Arg Phe Ala Pro Leu Ala Leu Gln Tyr Leu Asp Ser 
        355                 360                 365             


Gln Lys Ala Phe Asn Asp Ile Arg Phe Met Val Arg Leu Gly His Tyr 
    370                 375                 380                 


Arg Phe Lys Phe Tyr Lys Lys Gln Cys Val Ala Asp Asn Ala Pro Asp 
385                 390                 395                 400 


Thr Leu Arg Val Leu Gln Lys Glu Ile Asn Gly Phe Gly Arg Leu Asp 
                405                 410                 415     


Glu Met Glu Ala Ala Arg Lys Lys Asn Tyr Thr Pro Leu Phe Lys Ala 
            420                 425                 430         


Thr Cys Val Lys Thr Asn Asp Lys Gly Ile Glu Val His Glu Leu Val 
        435                 440                 445             


Pro Asp Ala Pro Asp Ser Ala Pro Tyr Ile Thr Asp Thr Lys Ala His 
    450                 455                 460                 


Tyr Leu Ile Asp Asn Asn Arg Val Gly Leu Arg Ile Asp Asn Pro Ser 
465                 470                 475                 480 


Phe Leu Pro Ser Leu Arg Gly Glu Lys Gly Ala Pro Ile Gln Ser Ala 
                485                 490                 495     


Gly Asp Ile Ser Leu Leu Ser Pro Gln Ala Trp Leu Ser Thr Tyr Glu 
            500                 505                 510         


Leu Pro Gly Leu Val Phe Tyr Gln Tyr Leu Tyr Asp Thr Tyr Asp Gly 
        515                 520                 525             


His Gly Lys His Leu Pro Ser Ala Glu Glu Ile Ile Lys Ser Tyr Ile 
    530                 535                 540                 


Leu Ala Tyr Lys Arg Leu Phe Val Asp Leu Gly Glu Gly Ser Phe Asp 
545                 550                 555                 560 


Gly Trp Asp Glu Tyr Ala Tyr Ala Pro Leu Thr Leu Gly Asp Leu Pro 
                565                 570                 575     


Gln Lys Ile Lys Gly Phe Ile Leu His Pro Ser Ala Thr Ile Asp Pro 
            580                 585                 590         


Arg Phe Gln Asp Lys Ala Asn Asn Arg Ile Asp Asp Met Ile Lys Arg 
        595                 600                 605             


Thr Glu Ala Glu Ile Ala Gly Phe Asp Thr Lys Met Lys Lys Leu Ser 
    610                 615                 620                 


Asp Lys Ser Asn Lys Leu Gly Lys Lys Lys Tyr Val Asp Ile Arg Pro 
625                 630                 635                 640 


Gly Ser Ile Ala Ser Arg Leu Val Arg Asp Ile Leu Phe Phe Thr Pro 
                645                 650                 655     


Val Ser Glu Glu Lys Ala Lys Ile Thr Ser Ala Asn Phe Asn Ser Leu 
            660                 665                 670         


Gln Ser Ala Leu Ala Leu Ser Glu Leu Gly Thr Asn Arg Ile Lys Asp 
        675                 680                 685             


Ile Leu Arg Gly Leu Asn His Pro Phe Val Met Lys Ala Phe Glu Lys 
    690                 695                 700                 


Tyr Arg Val Glu Asp Phe His Leu Phe Asp Phe Trp Lys Val Tyr Leu 
705                 710                 715                 720 


Asn Lys Arg Leu Asp Tyr Leu Lys Gly Leu Asp Arg Glu Lys Leu Glu 
                725                 730                 735     


Glu Val Pro Phe Leu His Ser Ser Arg Thr Arg Trp Gln Lys Arg Asp 
            740                 745                 750         


Glu Lys Tyr Ile Lys Leu Leu Ala Gly Arg Tyr Glu Gln Phe Glu Leu 
        755                 760                 765             


Pro Arg Ser Leu Phe Thr Ala Pro Thr Arg Val Leu Leu Asp Glu Val 
    770                 775                 780                 


Ala Leu His Phe Glu Ser Gly Ser Asp Arg Asp Leu Ser Met Gly Asn 
785                 790                 795                 800 


Leu Ile Asn Leu Phe Phe Ser Lys Val Leu Ser Asp Asn Asn Gln Pro 
                805                 810                 815     


Phe Tyr Arg Trp Glu Arg His Tyr Asp Val Phe Asp Lys Leu Ala Gly 
            820                 825                 830         


Val Lys Ser Gly Ile Ser Leu Val His Gln Phe Phe Lys Pro Glu Gln 
        835                 840                 845             


Leu Ala Lys Lys Met Arg Glu Arg Lys Thr Leu Lys Pro Ser Leu Tyr 
    850                 855                 860                 


Met Cys Glu Lys Ala Val Asn Ser Val Asn Gln Asn Leu Lys Lys Gly 
865                 870                 875                 880 


Glu Arg Arg Leu Asn Ile His Ser Ser Thr Asp Leu Lys Asp Ser Arg 
                885                 890                 895     


Val Ile Ala Val Ala Lys Glu Asn Leu Lys Lys Ala Tyr Gln Asp Tyr 
            900                 905                 910         


Asp Asp Asn Glu Arg Ile Leu Arg Arg Phe Ala Ile Gln Asp Lys Val 
        915                 920                 925             


Met Tyr Leu Met Ala Lys Ser Ile Leu Leu Gly Ile Lys Gly Ile Glu 
    930                 935                 940                 


Ala Gly Ser Leu Asp Arg Phe Lys Leu Lys Asp Ile Leu Pro Gly Lys 
945                 950                 955                 960 


Asn Asn Thr Ile Leu Asp Ile Leu Val Pro Phe Ser Ile Val Leu Glu 
                965                 970                 975     


Ile Asp Gly Ile Lys Val Leu Ile Arg Gln Lys Glu Lys Val Lys Ile 
            980                 985                 990         


Lys Arg Tyr Gly Glu Phe Phe Arg  Tyr Asn Thr Asp Thr  Arg Leu Arg 
        995                 1000                 1005             


Ser Leu  Leu Pro Leu Leu Gly  Lys Thr Leu Gly Ala  Glu Thr Glu 
    1010                 1015                 1020             


Ile Asn  Val Glu Leu Asp Arg  Asp Thr Leu Glu Glu  Glu Leu Ser 
    1025                 1030                 1035             


Ala Tyr  Asp Arg Glu Arg Val  Val Val Met Arg Met  Val Met Ser 
    1040                 1045                 1050             


Leu Glu  Gln Ser Ile Leu Ser  Arg Ser Thr Gly Asp  Val Pro Glu 
    1055                 1060                 1065             


Met Asp  Arg Glu Asn Phe Asn  Asn Leu Val Ser Lys  Val Gly His 
    1070                 1075                 1080             


Ile Pro  Tyr Lys Ser His Gly  Gln Ile Leu Ile Asn  Ile Arg Asn 
    1085                 1090                 1095             


Ser Phe  Cys His Asn Glu Tyr  Ala Arg Asp Ile Val  Leu Pro Glu 
    1100                 1105                 1110             


Gly Thr  Pro Leu Pro Gln Val  Ala Glu Thr Ile Ser  Lys Leu Phe 
    1115                 1120                 1125             


Glu Thr  Glu Arg Lys Arg Arg  Pro Asn Gln Cys Gln  Glu 
    1130                 1135                 1140     


<210>  2705
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2705

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Thr 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2706
<211>  1090
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2706

Met Lys His Thr Tyr Asp Phe Leu Lys Lys Glu Asp Lys Tyr Phe Phe 
1               5                   10                  15      


Ala Gly Leu Phe Asn Thr Ala Lys Asp Asn Phe Asp Leu Ser Leu Asn 
            20                  25                  30          


Glu Leu Asn Lys Arg Leu Asn Tyr Lys Glu Ile Lys Gly Lys Asp Lys 
        35                  40                  45              


Glu Leu Arg Ile Ile Glu Tyr Ala Phe His Lys Asp Arg Thr Gln Leu 
    50                  55                  60                  


Asp Phe Asp Asn Ser Phe Lys Tyr Leu Ser Glu Ser Leu Ser Phe Leu 
65                  70                  75                  80  


Asn Arg Ile Gln Ser Phe Ile Ala Lys Lys Asn Asn Arg Thr Leu Ile 
                85                  90                  95      


Leu Arg Asn Phe Ile Lys Asp Phe Leu Ile Asp Leu Tyr Lys Leu Leu 
            100                 105                 110         


Asp Ser Asn Arg Asn Tyr Tyr Thr His Phe Glu His Glu Lys Val Thr 
        115                 120                 125             


Ile Asp Asn Pro Leu Ile Thr Glu Phe Leu Asp Tyr Ile Leu Phe Asn 
    130                 135                 140                 


Ser Ile Ser Arg Ile Lys Asp Asp Lys Val Lys Thr Glu Ser Val Lys 
145                 150                 155                 160 


Asp Lys Leu Leu Ser Lys Tyr Lys Asp Asp Tyr Ser Ile Ile Ile Asn 
                165                 170                 175     


Asn Lys Asn Lys Trp Ile Asp Glu Asn Asn Ile Lys Leu Lys Lys Glu 
            180                 185                 190         


Gly Lys Arg Thr Asn Lys Arg Ile Asn Asn Asn Thr Val Ala Gly Tyr 
        195                 200                 205             


Asn Tyr Val Leu Asn Ser Ile Phe Arg Arg Phe Ile Asp Asp Ser Thr 
    210                 215                 220                 


Lys Lys Pro His Leu Lys Glu Asp Ser Lys Ser Thr Glu Asn Asn Gly 
225                 230                 235                 240 


Leu Ser Tyr Val Gly Tyr Ile Gln Phe Leu Ala Leu Phe Leu Asn Lys 
                245                 250                 255     


Arg Gln Ile Asn Leu Leu Phe Asp Asn Ile Ser Tyr Thr Lys Tyr Thr 
            260                 265                 270         


Asp Thr Leu Leu Gln Arg Ile Ile Thr Arg Trp Ile Phe Thr Tyr Glu 
        275                 280                 285             


Ser Tyr Arg Asn Val Lys His Leu Phe Lys Ser Ser Tyr Asp His His 
    290                 295                 300                 


Ala Leu Leu Leu Gln Met Val Ser Glu Leu Thr Lys Cys Pro Asn Asn 
305                 310                 315                 320 


Leu Tyr Pro His Leu Ser Asp Lys Lys Lys Asp Glu Phe Val Glu Asp 
                325                 330                 335     


Leu Asn Ile Tyr Phe Gln Glu Asn Asp Asn Ser Phe Glu Asp Asp Thr 
            340                 345                 350         


Leu Ile Ser His Glu Val Ile Arg Lys Arg Tyr Glu Asp Lys Phe Pro 
        355                 360                 365             


Tyr Phe Ala Ile Arg Phe Leu Asp Asp Phe Met Asn Phe Pro Ser Leu 
    370                 375                 380                 


Arg Phe Gln Val Asn Met Gly Lys Phe Ile His Asp Ser Arg Glu Lys 
385                 390                 395                 400 


Glu Phe Asn Ser Thr Gly Lys Lys Thr Glu Arg Leu Ile Leu Glu Lys 
                405                 410                 415     


Leu Ile Val Phe Glu Asn Leu Ser Glu Ala Thr Lys Lys Lys Asn Leu 
            420                 425                 430         


Tyr Phe Glu Lys Thr Lys Asn Asn Lys Asn Thr Asp Trp Val Glu His 
        435                 440                 445             


Pro Arg Pro Lys Tyr Gln Phe Tyr Asn Asn Ser Ile Gly Ile Trp Leu 
    450                 455                 460                 


Asp Cys Asp Gly Leu Gly Tyr Tyr Glu Glu Glu Ala Thr Leu Arg Lys 
465                 470                 475                 480 


Ser Lys Pro Thr Lys Tyr Glu Ile Leu Asp Lys Leu Lys Leu Lys Asp 
                485                 490                 495     


Ser Tyr Lys Lys Pro Leu Ala Tyr Leu Ser Val Asn Glu Leu Pro Ala 
            500                 505                 510         


Ile Leu Tyr Ser Ile Leu Met Glu Gly Arg Asp Ser Met Tyr Ile Glu 
        515                 520                 525             


Asn Lys Ile Lys Gly Lys Ile Ile Gln Gln Arg Lys Phe Ile Glu Asn 
    530                 535                 540                 


Ile Ser Leu Glu Lys Asp Tyr Asn Asn Glu Glu Ile Lys Ser Phe Pro 
545                 550                 555                 560 


Lys Lys Leu Lys Leu Ile Leu Thr Glu Asn Ser Ser Ile Asn Lys Ala 
                565                 570                 575     


Lys Ile Lys Arg Gln Ile Thr Lys Glu Lys Glu Val Asn Pro Leu Gly 
            580                 585                 590         


Glu Ile Arg Lys Tyr Tyr Thr Pro Lys Asn Glu Thr Glu Leu Ser Leu 
        595                 600                 605             


Ser Glu Lys Gly Lys Ile Ala Thr Trp Leu Ser Lys Asp Ile Lys Arg 
    610                 615                 620                 


Phe Val Ala Lys Glu Val Lys Gly Pro Ser Glu Glu Asp Lys Asn Lys 
625                 630                 635                 640 


Ser Trp Lys Gly Tyr Gln Phe Ser Glu Phe Gln Ala Leu Leu Ser Tyr 
                645                 650                 655     


Tyr Asp Ile Asp Lys Ser Lys Leu Ser Leu Phe Leu Gln Lys Asp Leu 
            660                 665                 670         


Arg Leu Lys Ile Glu Asp Phe Pro Phe Lys Gly Leu Ser Phe Thr His 
        675                 680                 685             


Lys Ser Leu Tyr Asp Phe Tyr Val Asn Tyr Leu Ala Ser Arg Lys Glu 
    690                 695                 700                 


Tyr Leu Glu Phe Leu Leu Lys Asn Ile Glu His Leu Lys Asp Asp Ile 
705                 710                 715                 720 


Leu Leu Leu Pro Phe Asn Ala Ser Lys Phe Lys Ile Gln Gln Leu Glu 
                725                 730                 735     


Lys Tyr Lys Glu Asn Lys Leu Lys Gly Ala Val Met Leu Pro Arg Gly 
            740                 745                 750         


Ile Phe Asp Lys Lys Pro Thr Thr Ser Lys Glu Asn Asp Lys Thr Lys 
        755                 760                 765             


Phe Ala Asp Trp Phe Ala Met Ser Met Asn Asn Asn His Ala Gln Glu 
    770                 775                 780                 


Phe Tyr Asn Tyr Asn Lys Thr Tyr Leu Ile Asn Asp Asn Thr Ile Thr 
785                 790                 795                 800 


Ile Asn Pro Asn Ile Gly Ile Lys Glu Gln Tyr Lys Asn Ile Ala Ser 
                805                 810                 815     


Glu His Gln Lys Thr Ile Tyr Lys Asn Glu Val Val Ile Arg Lys Thr 
            820                 825                 830         


Met Arg Asn Asp Phe Tyr Val Leu Gln Met Ile Lys Ser Phe Phe Lys 
        835                 840                 845             


Asp Thr Ser Glu Val Asp Lys Glu Thr Phe Lys Asn Ile Thr Leu Lys 
    850                 855                 860                 


Asp Phe Tyr Leu Thr Lys Ala Glu Lys Glu Gln Thr Lys Lys Arg Ala 
865                 870                 875                 880 


Leu Glu Gln Ser Glu Arg Gln Lys Gly Asn Lys Glu Glu Asn Ile Phe 
                885                 890                 895     


Asn Glu Asn Tyr Ile Leu Asn Lys Arg Ile Lys Leu Ser Leu Leu Glu 
            900                 905                 910         


Gly Lys Ile Val Gly Glu Val Ser Leu Lys Glu Ser Ser Lys Tyr Lys 
        915                 920                 925             


Arg Leu Ser Lys Asp Pro Arg Val Ile Gln Leu Thr Asn Tyr Asn Glu 
    930                 935                 940                 


Asn Lys Val Trp Gly Phe Gln Glu Ile Ile Tyr Glu Ile Ile Asp Tyr 
945                 950                 955                 960 


Glu Leu Ile Lys Ser Asn Val Leu Phe Lys Thr Ile His Glu Leu Glu 
                965                 970                 975     


Lys Glu Ile Phe Leu Lys Ala Lys Ser Lys Asn Asp Leu Glu Leu Leu 
            980                 985                 990         


Thr Tyr Asn Gly His Pro Asn Phe  Lys Lys Tyr Leu Ala  Tyr Tyr Phe 
        995                 1000                 1005             


Ile Lys  Glu Glu Ser Lys Lys  Glu Glu Phe Asn Arg  Ile Asn Ile 
    1010                 1015                 1020             


Gln Thr  Val Asp Leu Leu Thr  Ile Asp Asp Asp Leu  Lys Asn Leu 
    1025                 1030                 1035             


Val Val  Leu Leu Leu Ile Arg  Asn Lys Phe Ser His  Asn Gln Leu 
    1040                 1045                 1050             


Val Ser  Lys Leu Val Phe Asp  Tyr Leu Ile Thr Tyr  Tyr Pro Lys 
    1055                 1060                 1065             


Asn Pro  Asn Glu Lys Val Ala  Ser Tyr Leu Asn Arg  Val Phe Gly 
    1070                 1075                 1080             


Ile Ile  Ile Asp Ser Leu Lys  
    1085                 1090 


<210>  2707
<211>  1131
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2707

Met Glu Lys Thr Ile Glu Asn Gln Thr Gln Ser Lys Arg Thr Leu Asn 
1               5                   10                  15      


Asn Thr Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Asp Glu Glu Lys Ile Thr Thr Ser Phe Leu Val Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Arg Gln Ser Leu Val Tyr Ser Asn Leu Thr 
65                  70                  75                  80  


Arg Tyr Met His Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Asp 
                85                  90                  95      


Asp Glu Arg Asp Lys Ala Glu Asn Tyr Gly Lys Asp Phe Gly Asn Leu 
            100                 105                 110         


Thr Asp Thr Leu Lys Glu Ile Phe Lys Glu Leu Asn Glu Phe Arg Asn 
        115                 120                 125             


Asp Tyr Ser His Tyr Tyr Ser Thr Glu Lys Lys Asp Lys Arg Lys Thr 
    130                 135                 140                 


Ile Val Ser Asp Lys Leu Lys Asn Phe Leu Asn Ile Asn Tyr Thr Arg 
145                 150                 155                 160 


Ala Ile Lys Tyr Thr Lys Ser Arg Phe Ile Asn Val Phe Ser Asp Asn 
                165                 170                 175     


Asn Phe Cys Leu Ala Glu Glu Ala Lys His Val Glu Asn Asp Asn Thr 
            180                 185                 190         


Ile Thr Gln Asp Gly Ile Val Phe Phe Thr Ser Met Phe Leu Asp Arg 
        195                 200                 205             


Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile Ile Gly Leu Lys Gly Thr 
    210                 215                 220                 


Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Thr Leu Met Ala Phe Cys 
225                 230                 235                 240 


Val Asn Leu Pro His Asp Lys Phe Val Ser Glu Asn Ser Glu Gln Gln 
                245                 250                 255     


Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu 
            260                 265                 270         


Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln His Phe Leu Pro Lys Leu 
        275                 280                 285             


Asp Asp Glu Gln Ile Asp Asn Val Leu Glu Asn Ser Val Pro Tyr Thr 
    290                 295                 300                 


Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn Ile Thr Lys Lys Val Arg 
305                 310                 315                 320 


Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu Lys Phe Ile Asp Gln Lys 
                325                 330                 335     


Lys Leu Phe Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val 
            340                 345                 350         


Leu Asp Glu Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Lys Arg Thr 
        355                 360                 365             


Val Thr Glu Asn Thr Lys Ala Phe Gly Met Leu Gln Asp Leu Asn Asp 
    370                 375                 380                 


Glu Glu Asn Val Leu Asn Lys Ile Asn Thr Gly Glu Ser Lys Ala Lys 
385                 390                 395                 400 


Phe Asp Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Thr Lys Asn 
            420                 425                 430         


Thr Asp Asn Lys Ile Lys Ser Asn Leu Leu Gln Pro Leu Pro Glu Ala 
        435                 440                 445             


Phe Leu Ser Ile Asn Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
    450                 455                 460                 


Glu Gln Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn 
465                 470                 475                 480 


Asn Ser Lys Ile Leu Asn Lys Glu Phe Ile Lys Ala Ile Lys Leu Lys 
                485                 490                 495     


Leu Asn Asp Leu Asp Val Phe Tyr Lys Arg Ser Gln Gly Arg Lys Gln 
            500                 505                 510         


Lys His Ala Tyr Leu Thr Lys Asp Lys Lys Tyr Asp Asn Glu Lys Ile 
        515                 520                 525             


Asn Glu Leu Lys Asn Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu 
    530                 535                 540                 


Tyr Asn Leu Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp 
545                 550                 555                 560 


Leu Asn Ile Ala Asp Val Gln Ala Lys Asn Ala Ile Ser Asp Arg Ile 
                565                 570                 575     


Lys Leu Met Lys Arg Asp Cys Ile Asn Arg Leu Lys Ser Met Lys Lys 
            580                 585                 590         


Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp 
        595                 600                 605             


Ile Val Asp Met Ile Ile Asp Glu Glu Lys Lys Lys Lys Ile Thr Ser 
    610                 615                 620                 


Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Lys 
625                 630                 635                 640 


Glu Lys Lys Glu Leu Phe Ile Leu Ile Cys Asn Asn Glu Leu Lys Leu 
                645                 650                 655     


Asn Asp Asp Asp Gly His Pro Phe Phe Lys Asn Ile Asn Phe Ser Asn 
            660                 665                 670         


Tyr Lys Tyr Thr Ser Glu Ile Tyr Gln Lys Tyr Leu Glu Glu Lys Gly 
        675                 680                 685             


His Lys Met Val Lys Glu Tyr Asn Pro Arg Lys Glu Asn Tyr Val Glu 
    690                 695                 700                 


Lys Asp Lys Ser Trp Leu Glu Ile Asn Phe Tyr Lys Lys Glu Trp Asn 
705                 710                 715                 720 


Glu Asn Ala Lys Lys Asp Leu Thr Val Val Lys Leu Pro Asp Asp Lys 
                725                 730                 735     


Ser Lys Ile Pro Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser 
            740                 745                 750         


Phe Glu Asn Trp Phe Lys Tyr Val Thr Asn Gly Lys Glu Thr Thr Asp 
        755                 760                 765             


Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp Glu Thr Leu 
    770                 775                 780                 


Lys Glu Leu Leu Lys Lys Glu Leu Ser Lys Asn Asn Ile Glu Phe Lys 
785                 790                 795                 800 


Glu Glu Asp Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Asp Lys Cys 
                805                 810                 815     


Arg Asn Asp Lys Thr Gln Lys Phe Tyr Ser Ala Glu Arg Glu Tyr Thr 
            820                 825                 830         


Phe Glu Glu Glu Lys Leu Asn Phe His Ile Asn Thr Lys Ser Lys Phe 
        835                 840                 845             


Glu Glu Tyr Ile Asn Pro Glu Phe Ala Glu Lys Val Phe Arg Leu Lys 
    850                 855                 860                 


Asn Gln Asn Arg Glu Lys Asp Asn Ile Ser Gly Arg Arg Leu Pro Pro 
865                 870                 875                 880 


Leu Lys Met Lys Glu Val Thr Lys Asn Met Val Lys Arg Ile Gly Asn 
                885                 890                 895     


Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Leu Met Leu 
            900                 905                 910         


Leu Met Phe Glu Lys Leu Val Asp Asn Asn Leu Lys Leu Lys Leu Glu 
        915                 920                 925             


Asn Val Asp Lys Leu Leu Asn Glu Ser Ile Glu Ile Asn Gln Ser Ile 
    930                 935                 940                 


Ser Gly Lys Leu Ser Phe Asp Asp Ser Gly Asp Asn Glu Asn Lys Lys 
945                 950                 955                 960 


Asp Arg Ala Ile Ile Cys Arg Asn Ile Thr Glu Thr Arg Lys Arg Lys 
                965                 970                 975     


Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Glu Glu Glu  Asn Ile Pro Ile Glu  Lys Ile Lys 
        995                 1000                 1005             


Ile Glu  Leu Asp Thr Tyr Ser  Lys Ala Lys Asp Val  Val Phe Asp 
    1010                 1015                 1020             


Leu Ile  Phe Asp Leu Glu Arg  Ala Ile Ile Asn Lys  Asp Glu Asn 
    1025                 1030                 1035             


Arg Ile  Lys Glu Leu Asn Lys  Asp Lys Asn Gly Val  Ile Gln Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Phe Trp Leu  Leu Glu Lys 
    1055                 1060                 1065             


Asn Leu  Ile Thr Glu Gln Glu  Phe Thr Phe Met Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Thr  Phe Ser His Asn Gln  Phe Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Leu Phe  Ile Lys Asn Trp Asn  Glu Asn Glu Phe Ala  Lys Gln Ile 
    1100                 1105                 1110             


Leu Asn  Val Tyr Asn Gln Lys  Asn Asn Asn Leu Ile  Lys Ser Ile 
    1115                 1120                 1125             


Lys Asp  Ile 
    1130     


<210>  2708
<211>  1131
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2708

Met Glu Lys Thr Ile Glu Asn Gln Thr Gln Ser Lys Arg Thr Leu Asn 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Asp Glu Glu Lys Ile Thr Thr Ser Phe Leu Val Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Arg Gln Ser Leu Val Tyr Ser Asn Leu Thr 
65                  70                  75                  80  


Arg Tyr Met His Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Asp 
                85                  90                  95      


Asp Glu Arg Asp Lys Ala Glu Asn Tyr Gly Lys Asp Phe Gly Asn Leu 
            100                 105                 110         


Thr Asp Thr Leu Lys Glu Ile Phe Lys Glu Leu Asn Glu Phe Arg Asn 
        115                 120                 125             


Asp Tyr Ser His Tyr Tyr Ser Thr Glu Lys Lys Asp Lys Arg Lys Thr 
    130                 135                 140                 


Ile Val Ser Asp Lys Leu Lys Asn Phe Leu Asn Ile Asn Tyr Thr Arg 
145                 150                 155                 160 


Ala Ile Lys Tyr Thr Lys Ser Arg Phe Ile Asn Val Phe Ser Asp Asn 
                165                 170                 175     


Asn Phe Cys Leu Ala Glu Glu Ala Lys His Val Glu Asn Asp Asn Thr 
            180                 185                 190         


Ile Thr Gln Asp Gly Ile Val Phe Phe Thr Ser Met Phe Leu Asp Arg 
        195                 200                 205             


Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile Ile Gly Leu Lys Gly Thr 
    210                 215                 220                 


Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Thr Leu Met Ala Phe Cys 
225                 230                 235                 240 


Val Asn Leu Pro His Asp Lys Phe Val Ser Glu Asn Ser Glu Gln Gln 
                245                 250                 255     


Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu 
            260                 265                 270         


Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln His Phe Leu Pro Lys Leu 
        275                 280                 285             


Asp Asp Glu Gln Ile Asp Asn Val Leu Glu Asn Ser Val Pro Tyr Thr 
    290                 295                 300                 


Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn Ile Thr Lys Lys Val Arg 
305                 310                 315                 320 


Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu Lys Phe Ile Asp Gln Lys 
                325                 330                 335     


Lys Leu Phe Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val 
            340                 345                 350         


Leu Asp Glu Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Lys Arg Thr 
        355                 360                 365             


Val Thr Glu Asn Thr Lys Ala Phe Gly Met Leu Gln Asp Leu Asn Asp 
    370                 375                 380                 


Glu Glu Asn Val Leu Asn Lys Ile Asn Thr Gly Glu Ser Lys Ala Lys 
385                 390                 395                 400 


Phe Asp Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Thr Lys Asn 
            420                 425                 430         


Thr Asp Asn Lys Ile Lys Ser Asn Leu Leu Gln Pro Leu Pro Glu Ala 
        435                 440                 445             


Phe Leu Ser Ile Asn Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
    450                 455                 460                 


Glu Gln Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn 
465                 470                 475                 480 


Asn Ser Lys Ile Leu Asn Lys Glu Phe Ile Lys Ala Ile Lys Leu Lys 
                485                 490                 495     


Leu Asn Asp Leu Asp Val Phe Tyr Lys Arg Ser Gln Gly Arg Lys Gln 
            500                 505                 510         


Lys His Ala Tyr Leu Thr Lys Asp Lys Lys Tyr Asp Asn Glu Lys Ile 
        515                 520                 525             


Asn Glu Leu Lys Asn Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu 
    530                 535                 540                 


Tyr Asn Leu Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp 
545                 550                 555                 560 


Leu Asn Ile Ala Asp Val Gln Ala Lys Asn Ala Ile Ser Asp Arg Ile 
                565                 570                 575     


Lys Leu Met Lys Arg Asp Cys Ile Asn Arg Leu Lys Ser Met Lys Lys 
            580                 585                 590         


Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp 
        595                 600                 605             


Ile Val Asp Met Ile Ile Asp Glu Glu Lys Lys Lys Lys Ile Thr Ser 
    610                 615                 620                 


Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Lys 
625                 630                 635                 640 


Glu Lys Lys Glu Leu Phe Ile Leu Ile Cys Asn Asn Glu Leu Lys Leu 
                645                 650                 655     


Asn Asp Asp Asp Gly His Pro Phe Phe Lys Asn Ile Asn Phe Ser Asn 
            660                 665                 670         


Tyr Lys Tyr Thr Ser Glu Ile Tyr Gln Lys Tyr Leu Glu Glu Lys Gly 
        675                 680                 685             


His Lys Met Val Lys Glu Tyr Asn Pro Arg Lys Glu Asn Tyr Val Glu 
    690                 695                 700                 


Lys Asp Lys Ser Trp Leu Glu Ile Asn Phe Tyr Lys Lys Glu Trp Asn 
705                 710                 715                 720 


Glu Asn Ala Lys Lys Asp Leu Thr Val Val Lys Leu Pro Asp Asp Lys 
                725                 730                 735     


Ser Lys Ile Pro Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser 
            740                 745                 750         


Phe Glu Asn Trp Phe Lys Tyr Val Thr Asn Gly Lys Glu Thr Thr Asp 
        755                 760                 765             


Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp Glu Thr Leu 
    770                 775                 780                 


Lys Glu Leu Leu Lys Lys Glu Leu Ser Lys Asn Asn Ile Glu Phe Lys 
785                 790                 795                 800 


Glu Glu Asp Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Asp Lys Cys 
                805                 810                 815     


Arg Asn Asp Lys Thr Gln Lys Phe Tyr Ser Ala Glu Arg Glu Tyr Thr 
            820                 825                 830         


Phe Glu Glu Glu Lys Leu Asn Phe His Ile Asn Thr Lys Ser Lys Phe 
        835                 840                 845             


Glu Glu Tyr Ile Asn Pro Glu Phe Ala Glu Lys Val Phe Arg Leu Lys 
    850                 855                 860                 


Asn Gln Asn Arg Glu Lys Asp Asn Ile Ser Gly Arg Arg Leu Pro Pro 
865                 870                 875                 880 


Leu Lys Met Lys Glu Val Thr Lys Asn Met Val Lys Arg Ile Gly Asn 
                885                 890                 895     


Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Leu Met Leu 
            900                 905                 910         


Leu Met Phe Glu Lys Leu Val Asp Asn Asn Leu Lys Leu Lys Leu Glu 
        915                 920                 925             


Asn Val Asp Lys Leu Leu Asn Glu Ser Ile Glu Ile Asn Gln Ser Ile 
    930                 935                 940                 


Ser Gly Lys Leu Ser Phe Asp Asp Ser Gly Asp Asn Glu Asn Lys Lys 
945                 950                 955                 960 


Asp Arg Ala Ile Ile Cys Arg Asn Ile Thr Glu Thr Arg Lys Arg Lys 
                965                 970                 975     


Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Glu Glu Glu  Asn Ile Pro Ile Glu  Lys Ile Lys 
        995                 1000                 1005             


Ile Glu  Leu Asp Thr Tyr Ser  Lys Ala Lys Asp Val  Val Phe Asp 
    1010                 1015                 1020             


Leu Ile  Phe Asp Leu Glu Arg  Ala Ile Ile Asn Lys  Asp Glu Asn 
    1025                 1030                 1035             


Arg Ile  Lys Glu Leu Asn Lys  Asp Lys Asn Gly Val  Ile Gln Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Phe Trp Leu  Leu Glu Lys 
    1055                 1060                 1065             


Asn Leu  Ile Thr Glu Gln Glu  Phe Thr Phe Met Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Thr  Phe Ser His Asn Gln  Phe Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Leu Phe  Ile Lys Asn Trp Asn  Glu Asn Glu Phe Ala  Lys Gln Ile 
    1100                 1105                 1110             


Leu Asn  Val Tyr Asn Gln Lys  Asn Asn Asn Leu Ile  Lys Ser Ile 
    1115                 1120                 1125             


Lys Asp  Ile 
    1130     


<210>  2709
<211>  1131
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2709

Met Glu Lys Thr Ile Glu Asn Gln Thr Gln Ser Lys Arg Thr Leu Asn 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Asp Glu Glu Lys Ile Thr Thr Ser Phe Leu Val Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Arg Gln Ser Leu Val Tyr Ser Asn Leu Thr 
65                  70                  75                  80  


Arg Tyr Met His Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Asp 
                85                  90                  95      


Asp Glu Arg Asp Lys Ala Glu Asn Tyr Gly Lys Asp Phe Gly Asn Leu 
            100                 105                 110         


Thr Asp Thr Leu Lys Glu Ile Phe Lys Glu Leu Asn Glu Phe Arg Asn 
        115                 120                 125             


Asp Tyr Ser His Tyr Tyr Ser Thr Glu Lys Lys Asp Lys Arg Lys Thr 
    130                 135                 140                 


Ile Val Ser Asp Lys Leu Lys Asn Phe Leu Asn Ile Asn Tyr Thr Arg 
145                 150                 155                 160 


Ala Ile Lys Tyr Thr Lys Ser Arg Phe Ile Asn Val Phe Ser Asp Asn 
                165                 170                 175     


Asn Phe Cys Leu Ala Glu Glu Ala Lys His Val Glu Asn Asp Asn Thr 
            180                 185                 190         


Ile Thr Gln Asp Gly Ile Val Phe Phe Thr Ser Met Phe Leu Asp Arg 
        195                 200                 205             


Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile Ile Gly Leu Lys Gly Thr 
    210                 215                 220                 


Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Thr Leu Met Ala Phe Cys 
225                 230                 235                 240 


Val Asn Leu Pro His Asp Lys Phe Val Ser Glu Asn Ser Glu Gln Gln 
                245                 250                 255     


Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu 
            260                 265                 270         


Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln His Phe Leu Pro Lys Leu 
        275                 280                 285             


Asp Asp Glu Gln Ile Asp Asn Val Leu Glu Asn Ser Val Pro Tyr Thr 
    290                 295                 300                 


Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn Ile Thr Lys Lys Val Arg 
305                 310                 315                 320 


Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu Lys Phe Ile Asp Gln Lys 
                325                 330                 335     


Lys Leu Phe Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val 
            340                 345                 350         


Leu Asp Glu Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Lys Arg Thr 
        355                 360                 365             


Val Thr Glu Asn Thr Lys Ala Phe Gly Met Leu Gln Asp Leu Asn Asp 
    370                 375                 380                 


Glu Glu Asn Val Leu Asn Lys Ile Asn Thr Gly Glu Ser Lys Ala Lys 
385                 390                 395                 400 


Phe Asp Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Thr Lys Asn 
            420                 425                 430         


Thr Asp Asn Lys Ile Lys Ser Asn Leu Leu Gln Pro Leu Pro Glu Ala 
        435                 440                 445             


Phe Leu Ser Ile Asn Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
    450                 455                 460                 


Glu Gln Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn 
465                 470                 475                 480 


Asn Ser Lys Ile Leu Asn Lys Glu Phe Ile Lys Ala Ile Lys Leu Lys 
                485                 490                 495     


Leu Asn Asp Leu Asp Val Phe Tyr Lys Arg Ser Gln Gly Arg Lys Gln 
            500                 505                 510         


Lys His Ala Tyr Leu Thr Lys Asp Lys Lys Tyr Asp Asn Glu Lys Ile 
        515                 520                 525             


Asn Glu Leu Lys Asn Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu 
    530                 535                 540                 


Tyr Asn Leu Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp 
545                 550                 555                 560 


Leu Asn Ile Ala Asp Val Gln Ala Lys Asn Ala Ile Ser Asp Arg Ile 
                565                 570                 575     


Lys Leu Met Lys Arg Asp Cys Ile Asn Arg Leu Lys Ser Met Lys Lys 
            580                 585                 590         


Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp 
        595                 600                 605             


Ile Val Asp Met Ile Ile Asp Glu Glu Lys Lys Lys Lys Ile Thr Ser 
    610                 615                 620                 


Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Lys 
625                 630                 635                 640 


Glu Lys Lys Glu Leu Phe Ile Leu Ile Cys Asn Asn Glu Leu Lys Leu 
                645                 650                 655     


Asn Asp Asp Asp Gly His Pro Phe Phe Lys Asn Ile Asn Phe Ser Asn 
            660                 665                 670         


Tyr Lys Tyr Thr Ser Glu Ile Tyr Gln Lys Tyr Leu Glu Glu Lys Gly 
        675                 680                 685             


His Lys Met Val Lys Glu Tyr Asn Pro Arg Lys Glu Asn Tyr Val Glu 
    690                 695                 700                 


Lys Asp Lys Ser Trp Leu Glu Ile Asn Phe Tyr Lys Lys Glu Trp Asn 
705                 710                 715                 720 


Glu Asn Ala Lys Lys Asp Leu Thr Val Val Lys Leu Pro Asp Asp Lys 
                725                 730                 735     


Ser Lys Ile Pro Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser 
            740                 745                 750         


Phe Glu Asn Trp Phe Lys Tyr Val Thr Asn Gly Lys Glu Thr Thr Asp 
        755                 760                 765             


Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp Glu Thr Leu 
    770                 775                 780                 


Lys Glu Leu Leu Lys Lys Glu Leu Ser Lys Asn Asn Ile Glu Phe Lys 
785                 790                 795                 800 


Glu Glu Asp Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Asp Lys Cys 
                805                 810                 815     


Arg Asn Asp Lys Thr Gln Lys Phe Tyr Ser Ala Glu Arg Glu Tyr Thr 
            820                 825                 830         


Phe Glu Glu Glu Lys Leu Asn Phe His Ile Asn Thr Lys Ser Lys Phe 
        835                 840                 845             


Glu Glu Tyr Ile Asn Pro Glu Phe Ala Glu Lys Val Phe Arg Leu Lys 
    850                 855                 860                 


Asn Gln Asn Arg Glu Lys Asp Asn Ile Ser Gly Arg Arg Leu Pro Pro 
865                 870                 875                 880 


Leu Lys Met Lys Glu Val Thr Lys Asn Met Val Lys Arg Ile Gly Asn 
                885                 890                 895     


Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Leu Met Leu 
            900                 905                 910         


Leu Met Phe Glu Lys Leu Val Asp Asn Asn Leu Lys Leu Lys Leu Glu 
        915                 920                 925             


Asn Val Asp Lys Leu Leu Asn Glu Ser Ile Glu Ile Asn Gln Ser Ile 
    930                 935                 940                 


Ser Gly Lys Leu Ser Phe Asp Asp Ser Gly Asp Asn Glu Asn Lys Lys 
945                 950                 955                 960 


Asp Arg Ala Ile Ile Cys Arg Asn Ile Thr Glu Thr Arg Lys Arg Lys 
                965                 970                 975     


Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Glu Glu Glu  Asn Ile Pro Ile Glu  Lys Ile Lys 
        995                 1000                 1005             


Ile Glu  Leu Asp Thr Tyr Ser  Lys Ala Lys Asp Val  Val Phe Asp 
    1010                 1015                 1020             


Leu Ile  Phe Asp Leu Glu Arg  Ala Ile Ile Asn Lys  Asp Glu Asn 
    1025                 1030                 1035             


Arg Ile  Lys Glu Leu Asn Lys  Asp Lys Asn Gly Val  Ile Gln Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Phe Trp Leu  Leu Glu Lys 
    1055                 1060                 1065             


Asn Leu  Ile Thr Glu Gln Glu  Phe Thr Phe Met Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Thr  Phe Ser His Asn Gln  Phe Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Leu Phe  Ile Lys Asn Trp Asn  Glu Asn Glu Phe Ala  Lys Gln Ile 
    1100                 1105                 1110             


Leu Asn  Val Tyr Asn Gln Lys  Asn Asn Asn Leu Ile  Lys Ser Ile 
    1115                 1120                 1125             


Lys Asp  Ile 
    1130     


<210>  2710
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2710

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Met Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Met Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Val Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2711
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2711

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Pro 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Met Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Met Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Ala Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2712
<211>  1129
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2712

Met Glu Thr Asn Gln Gln Thr His Glu Asn Arg Arg Arg Thr Leu Thr 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Asn Asn His Val Ala Thr Asp Phe Lys Arg Lys Pro 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Asp Ala Leu Leu Cys Asn Lys Thr 
    50                  55                  60                  


Ile Lys Asn Leu Asn Trp Asn His Val His Thr Arg Ala Leu Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ser Glu Ser Leu Pro Lys Asp Glu 
                85                  90                  95      


Arg Lys Asn Ser Asp Thr Glu Gly Lys Asp Phe Thr Ser Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Val Val Phe Ser Glu Leu Gln Glu Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Asp Ser Arg Lys Leu Ile Val 
    130                 135                 140                 


Ser Pro Glu Leu Ala Asn Phe Leu Thr Ile Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Thr Tyr Thr Lys Ala Arg Met Lys Asp Val Leu Thr Asp Ala Asp Tyr 
                165                 170                 175     


Ala Leu Val Glu Asn Leu Gln Met Val Ala Thr Asp Asn Lys Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Ile Ala Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ser Phe Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asn Gln Glu Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Ser 
            260                 265                 270         


Ile Ile Thr Asp Lys Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Glu Asn Leu Ile Ala Asn Ser Thr Asn Asn Glu Glu Arg 
    290                 295                 300                 


Glu Arg Ile Leu Asp Glu Ile Asp Tyr Gln Asp Tyr Ile Glu Gly Leu 
305                 310                 315                 320 


Thr Lys Arg Val Arg Tyr Asn Asn Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Asp Glu Lys Asn Ile Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Asn Tyr Thr Lys Gln Phe Ala Gly Glu 
        355                 360                 365             


Gln Ala Glu Arg Lys Val Leu Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asp Pro Glu Leu Ser Gln Gln Arg Ile Asp Lys Gln 
385                 390                 395                 400 


Gln Gln Thr Ala Gly Phe Glu Gln Phe Ala Pro Arg Tyr His Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Asn Ile Ala Thr Leu Thr 
            420                 425                 430         


Ala Lys Ser Lys Ala Gly Ser Lys Val Glu His Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Gln Ala Glu Glu Leu Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Leu Leu Asn Asp Thr Arg Leu Met Asp Ile Thr Phe Ile Glu Glu 
                485                 490                 495     


Val Lys Ser Gln Leu Pro Asp Gly Trp Asn Glu Phe Asn Lys Arg Ser 
            500                 505                 510         


Asp Ala Lys Lys Lys Lys Ala Tyr Ser Asp Ser Thr Leu Arg Tyr Leu 
        515                 520                 525             


His Gln Arg Lys Thr Ile Leu Asn Thr Ile Leu Ser Lys Tyr Asn Leu 
    530                 535                 540                 


Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Lys Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Thr Arg Leu Lys Ala Val Glu Lys His Lys Leu 
            580                 585                 590         


Asn Lys Ser Val Lys Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Glu Glu Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe 
625                 630                 635                 640 


Ala Asn Ala Glu Lys Lys Ala Leu Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Asn Asp Gly His Pro Phe Leu Gln Asn Ile Asn 
            660                 665                 670         


Leu Gln Gln Ile Arg Lys Thr Ser Gln Phe Tyr Gln Ala Tyr Leu Ile 
        675                 680                 685             


Glu Lys Gly Asn Lys Met Val Pro Arg Leu Asn Pro Lys Thr Asn Lys 
    690                 695                 700                 


Thr Ser Lys Val Asp Glu Ser Trp Met Met Lys Gln Phe Tyr Val Lys 
705                 710                 715                 720 


Glu Trp Lys Glu Glu Ile Ala Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Ala Asn Lys Ser Arg Ile Pro Phe Thr Ile Arg Gln Trp Asp Glu Lys 
            740                 745                 750         


Glu Lys Tyr Asp Leu Asn Thr Trp Leu Arg His Val Thr Val Gly Lys 
        755                 760                 765             


Asn Asn Asp Gly Lys Lys Ala Val Asn Leu Pro Thr Asn Leu Phe Asp 
    770                 775                 780                 


Glu Ala Leu Cys Asp Leu Leu Arg Glu Gln Leu Asp Thr Lys Ile Val 
785                 790                 795                 800 


Asn Tyr Asn Pro Ala Ala Asn Tyr Asn Glu Leu Leu Lys Ile Trp Trp 
                805                 810                 815     


Lys Thr Arg Asn Asp Asp Thr Gln Gln Phe Tyr Gln Ser Glu Arg Glu 
            820                 825                 830         


Tyr Asn Ile Tyr Asn Glu Lys Val Arg Phe Lys Ile Asp Ser Ser Ala 
        835                 840                 845             


His Phe Ala Asp Tyr Tyr Lys Asn Ala Leu Ser Arg Ala Phe Thr Arg 
    850                 855                 860                 


Leu Lys Ala Glu Arg Glu Thr Ala Arg Gln Ser Asn Lys Arg Leu Pro 
865                 870                 875                 880 


Pro Leu Glu Tyr Lys Gln Val Glu Arg Val Phe Lys Asn Thr Ile Ala 
                885                 890                 895     


Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met Ala 
            900                 905                 910         


Val Leu Met Leu Glu Arg Leu Met Asp Asn Ser Pro Asn Leu Arg Leu 
        915                 920                 925             


Ser Lys Ile Glu Thr Leu Leu Asn Asp Thr Thr Pro Ile Arg Glu Lys 
    930                 935                 940                 


Ile Ser Ala Thr Leu Ser Phe Asp Ala Ser Gly Glu Arg Ile Ser Gly 
945                 950                 955                 960 


Lys Ser Asn Pro Thr Val Thr Lys Thr Leu Val Ala Glu Arg Lys Gln 
                965                 970                 975     


Lys Asn Tyr Thr Glu Leu Arg Lys Tyr Arg Tyr Asp Arg Arg Leu Pro 
            980                 985                 990         


Glu Leu Phe Glu Tyr Val Gln Ala  Asp Glu Ile Pro Leu  Glu Trp Leu 
        995                 1000                 1005             


Leu Glu  Glu Leu Ser Ala Tyr  Asn Asn Ala Lys Gln  Gln Val Phe 
    1010                 1015                 1020             


Asp Thr  Val Phe Thr Leu Glu  Lys Lys Ile Ile Gly  Thr Asp Pro 
    1025                 1030                 1035             


Asp Gly  Leu Lys Ser Leu Phe  Thr Gly Ala Asn Gly  Glu Leu Gln 
    1040                 1045                 1050             


Thr Gly  Asn Ile Gln His Lys  Pro Tyr Val Gln Trp  Leu Thr Asn 
    1055                 1060                 1065             


Lys Gly  Leu Ile Asn Lys Glu  Glu Lys Gln Phe Ile  Asn Met Val 
    1070                 1075                 1080             


Arg Lys  Cys Phe Ser His Asn  Gln Phe Pro Gln Arg  Lys Thr Met 
    1085                 1090                 1095             


Glu Leu  Leu Ile Pro Ala Trp  Asn Glu Lys Lys Leu  Ala Leu Gln 
    1100                 1105                 1110             


Ile Ala  Thr Val Tyr Asn Gln  Leu Ile Ala Asp Leu  Thr Asn Lys 
    1115                 1120                 1125             


Ile 
    


<210>  2713
<211>  1139
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2713

Met Glu Asn Asn Pro Ser Asn Arg Phe Ser Lys Pro Ala Val Pro Pro 
1               5                   10                  15      


Lys Thr Arg Arg Ser Glu Gly Cys Glu Lys Pro Asp Ser His Ser Ala 
            20                  25                  30          


Glu Leu Lys Pro Val Phe Ala Ala Tyr Leu Asn Met Ala Gln Met Asn 
        35                  40                  45              


Leu Phe Asp Thr Leu Met Tyr Ile Gly Lys Lys Val Asp Val Val Asp 
    50                  55                  60                  


Lys Val Lys Ala Ser Glu Met Asp Gln Met Lys Ile Val His Tyr Ala 
65                  70                  75                  80  


Glu Leu Val Lys Pro Glu Leu Val Ala Lys Val Arg Glu Glu Leu Glu 
                85                  90                  95      


Arg Ser Ile Pro Phe Leu Phe Lys Leu Leu Lys Asp Gly Arg Glu Glu 
            100                 105                 110         


Pro Thr Asn Glu Tyr Val Ser Arg Thr Leu Gly Asp Ile Ile Lys Ile 
        115                 120                 125             


Ile Asp Tyr Arg Arg Asn Glu Tyr Thr His Thr Gln His Lys Arg Asn 
    130                 135                 140                 


Asn Ala Lys Asp Glu Glu Ser Arg Leu Leu Ser Val Lys Lys Lys Ala 
145                 150                 155                 160 


Glu Gly Lys Asp Thr Ser Phe Glu Pro Leu Gln Thr Ala Leu Met Ser 
                165                 170                 175     


Glu Arg Lys Ala Val Ala Gln Glu Met Cys Leu Ser Lys Lys Glu Met 
            180                 185                 190         


Glu Phe Ile Asp Lys Glu Ala Tyr Leu Asn Met Gly Asp Asp Asp Asn 
        195                 200                 205             


Ala Leu Leu Ser Asp Met Gly Met Ala Phe Leu Ile Cys Lys Leu Leu 
    210                 215                 220                 


Gln Lys Lys Tyr Ala Tyr Gln Phe Leu Gln Gln Ser Lys Leu Phe Thr 
225                 230                 235                 240 


Ser Arg Gly Lys Gly Gly His Ser Pro Phe Ser Ala Glu Lys Asn Lys 
                245                 250                 255     


Val Leu Ala Arg Ile Phe Cys Ser Asp Thr Ile Lys Leu Pro Lys Gly 
            260                 265                 270         


Arg Ile Glu Val Glu Ser Asn Asp Pro Lys Ala Ala Leu Gly Ile Asp 
        275                 280                 285             


Met Leu Asn Glu Leu Gln Lys Cys Pro Glu Glu Leu Tyr Arg Thr Leu 
    290                 295                 300                 


Ser Lys Asp Gly Arg Glu Leu Phe Val Val Asp Gly Leu Ala Asp Gly 
305                 310                 315                 320 


Glu Tyr Ile Glu Met Lys Arg His Gly Asp Arg Phe Pro Ile Leu Ala 
                325                 330                 335     


Leu Arg Tyr Ile Asp Glu Leu Asp Ile Leu Asn Gly Met Ala Phe Gln 
            340                 345                 350         


Val Arg Leu Gly Thr Tyr Arg Tyr Lys Phe Tyr Asn Lys Lys Ala Ile 
        355                 360                 365             


Asp Ala Asn Lys Pro Asn Arg Val Arg Ile Leu Gln Lys Glu Ile Asn 
    370                 375                 380                 


Gly Phe Gly Pro Ile Gln Lys Met Glu Ser Leu Arg Lys Glu Asn Tyr 
385                 390                 395                 400 


Lys Asn Leu Ile Arg Trp Thr Glu Gln Glu Glu Glu Tyr Thr Arg Asp 
                405                 410                 415     


Thr Ala Asn Thr Lys Pro Tyr Leu Thr Asn Ser Arg Thr Ser Tyr Ile 
            420                 425                 430         


Ile Asn Ser Asn Arg Ile Gly Leu Thr Trp Asn Asp Leu Gly Gln Asn 
        435                 440                 445             


Ile Leu Asp Glu Lys Asn Cys Phe Leu Pro Thr Leu Pro Thr Pro Gln 
    450                 455                 460                 


Lys Asn Gly Asp Asp Trp Thr Val Glu Trp Pro Arg Gly Gly Cys Glu 
465                 470                 475                 480 


Asn Asn Glu Asn Cys Gln Ile Pro Lys Cys Trp Leu Ser Val Tyr Asp 
                485                 490                 495     


Leu Pro Ala Leu Leu Phe Leu His His Leu Gly Gly Asp Pro Ser Gly 
            500                 505                 510         


Ile Ile Lys Gly Phe Arg Glu Asn Met Leu Arg Leu Leu Val Glu Ile 
        515                 520                 525             


Ala Glu Gly Ser Arg Lys Ala Tyr Phe Gly Thr Pro Leu Pro Gly Asn 
    530                 535                 540                 


Lys Asp Glu Arg Lys Thr Glu Ile Lys Arg Arg Lys Gly Glu Leu Asp 
545                 550                 555                 560 


Thr Phe Leu Arg Gln Asp Tyr Cys Trp Glu Ile Asp Tyr Asn Ala Tyr 
                565                 570                 575     


Cys Leu Gln Val Arg Asn Leu Pro Val Lys Ile Val Asp Tyr Leu Ile 
            580                 585                 590         


Gly Ile Ser Gly Gly Ser Arg Glu Val Glu Glu Pro Lys Ala Glu Thr 
        595                 600                 605             


Asp Phe Asn Asn Trp Ala Lys Glu Lys Val Cys Arg Glu Ile Gln Glu 
    610                 615                 620                 


Ile Arg Lys Ile Lys Asn Ser Ile Glu Arg Ala Glu Gln Asp Asn Asn 
625                 630                 635                 640 


Asp Lys Lys Lys Arg Thr Ala Asp Lys Glu Lys Ile Asp Leu Arg Pro 
                645                 650                 655     


Gly Lys Leu Ala Gln Tyr Leu Ala Lys Asp Ile Met Lys Met Gln Pro 
            660                 665                 670         


Ala Asp Met Glu Lys Asn His Gln Gly Lys Leu Thr Gly Phe Asp Tyr 
        675                 680                 685             


Asp Val Met Gln Gly Ala Ile Ala Thr Tyr Thr Gly Ser Thr Val Glu 
    690                 695                 700                 


Cys Lys His Thr Lys Leu Gly Glu Leu Phe Ser Asn Ala Gly Leu Ile 
705                 710                 715                 720 


Asp Ser Thr Ser Lys Asn Lys His Pro Phe Leu Asp Lys Val Met Glu 
                725                 730                 735     


Lys Arg Ile Ser Gly Thr Leu Asp Phe Tyr Lys Lys Tyr Leu Asn Glu 
            740                 745                 750         


Lys Glu Lys Tyr Leu Lys Asn Val Cys Asp Ser Lys Ser Phe Lys Glu 
        755                 760                 765             


Ala Tyr Phe Leu His Asp Gly Leu Asn Asn His Lys Ala Lys Asp Leu 
    770                 775                 780                 


Gln Tyr Ile Arg Glu Leu Ala Leu Arg Tyr Lys Asp Thr Leu Gln Leu 
785                 790                 795                 800 


Pro Asp Gly Leu Phe Thr Glu Ala Ile Val Ala Lys Leu Lys Arg Asp 
                805                 810                 815     


Asn Val Thr Lys Thr His Ile Lys Asp Leu Ser Asp Ser Gln Leu Asn 
            820                 825                 830         


Asn Ala Ala Tyr Leu Ile Arg Val Tyr Phe Glu Glu Lys Tyr Lys Asp 
        835                 840                 845             


Lys Ser Gln Pro Phe Tyr Leu Ser Asp Asp Pro Val Phe Lys Arg Tyr 
    850                 855                 860                 


Tyr Lys Leu Ser Glu Asn Lys Gly Glu Tyr Lys Ser Glu Glu Glu Ile 
865                 870                 875                 880 


Cys Lys Leu Leu Gln Gln Leu Lys Lys Glu Lys Lys Asn Asn Ser Asp 
                885                 890                 895     


Asp Tyr Arg Lys Arg Leu Asn Phe Cys Arg Asp Asn Glu Lys Ala Ile 
            900                 905                 910         


Arg Arg Tyr Lys Thr Gln Asp Met Leu Leu Phe Leu Met Ser Lys Asp 
        915                 920                 925             


Leu Leu Phe Lys Gln Arg Val Leu Gly Asp Lys Phe Ile Asn Ser Leu 
    930                 935                 940                 


Gln Asp Phe Lys Leu Ser Lys Ile Gln Pro Ile Gly Arg Glu Asp Gly 
945                 950                 955                 960 


Pro Lys Asp Asn Thr Leu Asn Gln Gln Ile Ser Ser Leu Thr Val Lys 
                965                 970                 975     


Val Glu Leu Trp Lys Glu Asn Lys Ser Thr Gly Leu Lys Lys Glu Ile 
            980                 985                 990         


Ser Cys Asp Asp Leu Lys Leu Lys  Asn Ile Gly Asp Phe  Tyr Arg Met 
        995                 1000                 1005             


Val Phe  Asp Pro Arg Val Gly  Tyr Leu Leu Ser Leu  Phe Asp Asp 
    1010                 1015                 1020             


Lys Thr  Phe Lys Gln Asp Asp  Ile Arg Arg Glu Leu  Glu Val Phe 
    1025                 1030                 1035             


Asp Asn  Ser Arg Val Glu Val  Phe Ser Ile Val His  Arg Ile Glu 
    1040                 1045                 1050             


Asn Ala  Ile Tyr Lys Asp Asn  Lys Asn Glu Ile Asp  Asp Tyr Val 
    1055                 1060                 1065             


Ser Lys  Glu Thr Tyr Ile Gly  Phe Arg Glu Met Ile  Glu Lys Tyr 
    1070                 1075                 1080             


Asn Ser  Arg Tyr Asp Ala Gln  Thr Lys Glu Asn Ile  Ile Ala Ile 
    1085                 1090                 1095             


Arg Asn  Met Val Ser His Asn  Asn Tyr Met Asp Lys  Asp Glu Ile 
    1100                 1105                 1110             


Val Lys  Ile Ile Pro Lys Asp  Lys Ile Gln Leu Pro  Gln Val Met 
    1115                 1120                 1125             


Ser Gln  Leu Val Glu Trp Leu  Arg Gln His Ala 
    1130                 1135                 


<210>  2714
<211>  1126
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2714

Met Glu Thr Leu Thr Ile Pro Glu Val Ile Lys Cys Arg Thr Leu Ser 
1               5                   10                  15      


Asp Asp Pro Gln Phe Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Val Phe Asn Ile Ser Asn His Ile Ala Lys Glu Phe Asp Leu Pro Leu 
        35                  40                  45              


Leu Ala Glu Glu Asp His Leu Arg Asn Ser Phe Leu Cys Asn Lys Glu 
    50                  55                  60                  


Asn Lys Lys Ile Asn Trp Asn His Leu Tyr Ser Arg Thr Asn Arg Phe 
65                  70                  75                  80  


Leu Ser Val Leu Lys Val Phe Asp Ala Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Lys Thr Thr Asn Leu Glu Gly Lys Asp Phe Ala Leu Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Ile Val Phe Gly Glu Leu Gln Asp Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Thr Ile Arg Lys Thr Thr Val 
    130                 135                 140                 


Ser Asp Glu Met Ala Leu Phe Leu Lys Val Asn Phe Asn Arg Ala Ile 
145                 150                 155                 160 


Glu Tyr Thr Lys Glu Arg Phe Lys Gly Val Leu Asn Glu Glu Asp Phe 
                165                 170                 175     


Gln Leu Val Ala Ser Lys Lys Val Met Glu Ala Asn Leu Thr Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Cys Leu Ile Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Thr Gly Leu Lys Gly Thr Glu Asn 
    210                 215                 220                 


Lys Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro His Asp Arg Phe Gln Ser Asp Asn Thr Arg Gln Ala Phe Ser 
                245                 250                 255     


Leu Asp Leu Ile Asn Glu Leu Asn Arg Cys Pro Lys Val Leu Tyr Asn 
            260                 265                 270         


Ser Ile Thr Ala Ser Gly Lys Gln Ile Phe Gln Pro Lys Leu Asp Ile 
        275                 280                 285             


Leu Gly Ile Lys Asn Leu Leu Asp Asn Ser Thr Asn Ile Asp Glu Glu 
    290                 295                 300                 


Val Glu Asp Tyr Asp Glu Tyr Ile Glu Ala Leu Thr Lys Arg Ile Arg 
305                 310                 315                 320 


His Ser Asn Arg Phe Ser Asp Phe Ala Leu Lys Tyr Ile Asp Glu Thr 
                325                 330                 335     


Gly Ile Phe Asp Lys Phe Arg Phe Gln Ile Asp Leu Gly Lys Leu Leu 
            340                 345                 350         


Val Asp Glu Tyr Ala Lys Phe Phe Asn Ser Glu Glu Val Pro Arg Arg 
        355                 360                 365             


Ile Ile Glu Asn Val Lys Ala Phe Gly Lys Leu Asn Ser Phe Asn Asp 
    370                 375                 380                 


Glu Ala Lys Val Leu Thr Arg Ile Gly Asn Gly Tyr Pro Ser Lys Glu 
385                 390                 395                 400 


Phe Glu Gln Phe Ser Pro His Tyr Asn Thr Glu Asn Asn Lys Ile Gly 
                405                 410                 415     


Ile Ser Val Lys Glu Asp Thr Ala Lys Leu Arg Pro Asn Ser Lys Gly 
            420                 425                 430         


Glu Thr Gly Lys Lys Leu His Gln Pro Leu Pro Glu Ala Phe Leu Ser 
        435                 440                 445             


Leu His Glu Leu Pro Lys Val Ile Ile Leu Asp Tyr Leu Gln Lys Gly 
    450                 455                 460                 


Glu Pro Glu Arg Leu Ile Glu Asp Phe Ile Leu Ile Asn Asn Ser Lys 
465                 470                 475                 480 


Leu Met Thr Met Pro Phe Ile Glu Ala Val Lys Ser Gln Met Pro Lys 
                485                 490                 495     


Glu Trp Asp Asp Phe Arg Arg Arg Thr Asp Thr Lys Lys Glu Met Ala 
            500                 505                 510         


Tyr Asn Glu Lys Thr Leu Thr Tyr Leu Leu Glu Arg Lys Asn Thr Leu 
        515                 520                 525             


Asn Gln Val Leu Ala Glu Tyr Gln Leu Asn Asp Lys Gln Ile Pro Gly 
    530                 535                 540                 


Arg Ile Leu Asp Tyr Trp Leu Asn Ile Lys Asp Val Glu Glu Gly Arg 
545                 550                 555                 560 


Ala Val Ser Asp Arg Ile Lys Ser Ile Lys Arg Asp Cys Met Ser Arg 
                565                 570                 575     


Leu Arg Ala Leu Glu Lys Phe Lys Ile Asp Arg Asn Arg Asn Lys Ile 
            580                 585                 590         


Pro Lys Ile Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile Val Asp 
        595                 600                 605             


Met Val Ala Gly Glu Glu Lys Lys Gln Lys Ile Thr Ser Phe Tyr Tyr 
    610                 615                 620                 


Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Ser Asp Lys Lys 
625                 630                 635                 640 


Gln Leu Phe Ile His Thr Val Cys Asn Glu Leu Arg Leu Asn Glu Thr 
                645                 650                 655     


Gly Gly His Pro Phe Leu Tyr Lys Leu Asp Leu Gln His Ile Asn Ser 
            660                 665                 670         


Thr Ser Glu Phe Tyr Gly Lys Tyr Leu Gln Glu Lys Gly His Lys Met 
        675                 680                 685             


Val Arg Glu Lys Asn Leu Arg Thr Gly Arg Val Ala Glu Val Asp Gln 
    690                 695                 700                 


Ser Trp Met Ala Thr Thr Phe Tyr Lys Lys Glu Trp Asn Glu Lys Ile 
705                 710                 715                 720 


Gly Lys Gln Leu Thr Val Val Lys Leu Pro Leu Asn Lys Ser Lys Ile 
                725                 730                 735     


Pro Phe Thr Leu Arg Leu Leu Glu Glu Lys Thr Ile Tyr Thr Leu Asp 
            740                 745                 750         


Gln Trp Leu Gln Asn Leu Thr Lys Gly Arg Asn Pro Asn Asp Ala Lys 
        755                 760                 765             


His Pro Val Asn Leu Pro Thr Asn Leu Phe Asp Glu Arg Leu Thr Val 
    770                 775                 780                 


Leu Leu Arg His Asp Leu Asp Glu Arg Gln Ile Ser Tyr Pro Ser Asn 
785                 790                 795                 800 


Ser Tyr Asp Asn Glu Leu Phe Lys Ile Trp Trp Lys Ser Arg Ser Asp 
                805                 810                 815     


Ser Thr Gln Ser Phe Tyr Asn Ala Glu Arg Glu Tyr Val Ile Phe Gly 
            820                 825                 830         


Glu Lys Val Asn Phe Met Pro Asn Thr Lys Asp Asn Phe Ala Asp Tyr 
        835                 840                 845             


Tyr Gln His Ala Phe Thr Thr Ala Tyr Gln Lys Lys Arg Lys Glu Arg 
    850                 855                 860                 


Thr Leu Gln Gln Lys Glu Asp Arg Arg Leu Pro Asn Ile Gln Leu Glu 
865                 870                 875                 880 


Gln Val Glu Lys Thr Phe Lys Gln Thr Ile Ala Gly Thr Glu Lys Glu 
                885                 890                 895     


Ile Arg Met Leu Gln Glu Glu Asp Arg Ile Met Leu Leu Met Ile Glu 
            900                 905                 910         


Ser Leu Leu Glu Asp Gly Lys Lys Met Gln Leu Lys Leu Ser Glu Ile 
        915                 920                 925             


Asp Thr Leu Leu Asn Ala Ala Thr Glu Val Lys Gln Thr Val Ser Ala 
    930                 935                 940                 


Lys Leu Ser Phe Asn Asp Ser Gly Glu Leu Ile Lys Asp Lys Thr Asn 
945                 950                 955                 960 


Pro Ala Ile Val Arg Thr Ile Thr Val Ser Arg Lys Arg Lys Asp Tyr 
                965                 970                 975     


Ser Met Leu Arg Lys Phe Ile Phe Asp Arg Arg Leu Pro Glu Leu Phe 
            980                 985                 990         


Glu Tyr Phe Pro Glu Lys Glu Ile  Gln Leu Asp Ser Leu  Lys Glu Glu 
        995                 1000                 1005             


Leu Asp  Ala Tyr Asn Lys Ala  Lys His Glu Val Phe  Asp Val Val 
    1010                 1015                 1020             


Phe Glu  Leu Glu Ala Lys Ile  Ile Ala Lys Asp Ser  Asp Gly Ile 
    1025                 1030                 1035             


Gln Gln  Leu Phe Ala Asp Glu  Ser Gly Lys Pro Leu  Thr Gly Asn 
    1040                 1045                 1050             


Ile Gln  His Lys Pro Tyr Leu  Thr Trp Leu Lys Asn  Lys Gly Leu 
    1055                 1060                 1065             


Leu Asp  Asp Asn Thr Phe Thr  Phe Leu Asn Met Val  Arg Asn Cys 
    1070                 1075                 1080             


Phe Ser  His Asn Gln Tyr Pro  Gln Lys Lys Thr Met  Glu Arg Leu 
    1085                 1090                 1095             


Ile His  His Trp Glu Pro Asn  Arg Phe Ala Leu Thr  Ile Ala Ser 
    1100                 1105                 1110             


Lys Tyr  Lys Gln Glu Ile Ala  Arg Ile Met Glu Asp  Leu 
    1115                 1120                 1125     


<210>  2715
<211>  1126
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2715

Met Glu Thr Leu Thr Ile Pro Glu Val Ile Lys Cys Arg Thr Leu Ser 
1               5                   10                  15      


Asp Asp Pro Gln Phe Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Val Phe Asn Ile Ser Asn His Ile Ala Lys Glu Phe Asp Leu Pro Leu 
        35                  40                  45              


Leu Ala Glu Glu Asp His Leu Arg Asn Ser Phe Leu Cys Asn Lys Glu 
    50                  55                  60                  


Asn Lys Lys Ile Asn Trp Asn His Leu Tyr Ser Arg Thr Asn Arg Phe 
65                  70                  75                  80  


Leu Ser Val Leu Lys Val Phe Asp Ala Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Lys Thr Thr Asn Leu Glu Gly Lys Asp Phe Ala Leu Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Ile Val Phe Gly Glu Leu Gln Asp Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Thr Ile Arg Lys Thr Thr Val 
    130                 135                 140                 


Ser Asp Glu Met Ala Leu Phe Leu Lys Val Asn Phe Asn Arg Ala Ile 
145                 150                 155                 160 


Glu Tyr Thr Lys Glu Arg Phe Lys Gly Val Leu Asn Glu Glu Asp Phe 
                165                 170                 175     


Gln Leu Val Ala Ser Lys Lys Val Met Glu Ala Asn Leu Thr Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Cys Leu Ile Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Thr Gly Leu Lys Gly Thr Glu Asn 
    210                 215                 220                 


Lys Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro His Asp Arg Phe Gln Ser Asp Asn Thr Arg Gln Ala Phe Ser 
                245                 250                 255     


Leu Asp Leu Ile Asn Glu Leu Asn Arg Cys Pro Lys Val Leu Tyr Asn 
            260                 265                 270         


Ser Ile Thr Ala Ser Gly Lys Gln Ile Phe Gln Pro Lys Leu Asp Ile 
        275                 280                 285             


Leu Gly Ile Lys Asn Leu Leu Asp Asn Ser Thr Asn Ile Asp Glu Glu 
    290                 295                 300                 


Val Glu Asp Tyr Asp Glu Tyr Ile Glu Ala Leu Thr Lys Arg Ile Arg 
305                 310                 315                 320 


His Ser Asn Arg Phe Ser Asp Phe Ala Leu Lys Tyr Ile Asp Glu Thr 
                325                 330                 335     


Gly Ile Phe Asp Lys Phe Arg Phe Gln Ile Asp Leu Gly Lys Leu Leu 
            340                 345                 350         


Val Asp Glu Tyr Ala Lys Phe Phe Asn Ser Glu Glu Val Pro Arg Arg 
        355                 360                 365             


Ile Ile Glu Asn Val Lys Ala Phe Gly Lys Leu Asn Ser Phe Asn Asp 
    370                 375                 380                 


Glu Ala Lys Val Leu Thr Arg Ile Gly Asn Gly Tyr Pro Ser Lys Glu 
385                 390                 395                 400 


Phe Glu Gln Phe Ser Pro His Tyr Asn Thr Glu Asn Asn Lys Ile Gly 
                405                 410                 415     


Ile Ser Val Lys Glu Asp Thr Ala Lys Leu Arg Pro Asn Ser Lys Gly 
            420                 425                 430         


Glu Thr Gly Lys Lys Leu His Gln Pro Leu Pro Glu Ala Phe Leu Ser 
        435                 440                 445             


Leu His Glu Leu Pro Lys Val Ile Ile Leu Asp Tyr Leu Gln Lys Gly 
    450                 455                 460                 


Glu Pro Glu Arg Leu Ile Glu Asp Phe Ile Leu Ile Asn Asn Ser Lys 
465                 470                 475                 480 


Leu Met Thr Met Pro Phe Ile Glu Ala Val Lys Ser Gln Met Pro Lys 
                485                 490                 495     


Glu Trp Asp Asp Phe Arg Arg Arg Thr Asp Thr Lys Lys Glu Met Ala 
            500                 505                 510         


Tyr Asn Glu Lys Thr Leu Thr Tyr Leu Leu Glu Arg Lys Asn Thr Leu 
        515                 520                 525             


Asn Gln Val Leu Ala Glu Tyr Gln Leu Asn Asp Lys Gln Ile Pro Gly 
    530                 535                 540                 


Arg Ile Leu Asp Tyr Trp Leu Asn Ile Lys Asp Val Glu Glu Gly Arg 
545                 550                 555                 560 


Ala Val Ser Asp Arg Ile Lys Ser Ile Lys Arg Asp Cys Met Ser Arg 
                565                 570                 575     


Leu Arg Ala Leu Glu Lys Phe Lys Ile Asp Arg Asn Arg Asn Lys Ile 
            580                 585                 590         


Pro Lys Ile Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile Val Asp 
        595                 600                 605             


Met Val Ala Gly Glu Glu Lys Lys Gln Lys Ile Thr Ser Phe Tyr Tyr 
    610                 615                 620                 


Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Ser Asp Lys Lys 
625                 630                 635                 640 


Gln Leu Phe Ile His Thr Val Cys Asn Glu Leu Arg Leu Asn Glu Thr 
                645                 650                 655     


Gly Gly His Pro Phe Leu Tyr Lys Leu Asp Leu Gln His Ile Asn Ser 
            660                 665                 670         


Thr Ser Glu Phe Tyr Gly Lys Tyr Leu Gln Glu Lys Gly His Lys Met 
        675                 680                 685             


Val Arg Glu Lys Asn Leu Arg Thr Gly Arg Val Ala Glu Val Asp Gln 
    690                 695                 700                 


Ser Trp Met Ala Thr Thr Phe Tyr Lys Lys Glu Trp Asn Glu Lys Ile 
705                 710                 715                 720 


Gly Lys Gln Leu Thr Val Val Lys Leu Pro Leu Asn Lys Ser Lys Ile 
                725                 730                 735     


Pro Phe Thr Leu Arg Leu Leu Glu Glu Lys Thr Ile Tyr Thr Leu Asp 
            740                 745                 750         


Gln Trp Leu Gln Asn Leu Thr Lys Gly Arg Asn Pro Asn Asp Ala Lys 
        755                 760                 765             


His Pro Val Asn Leu Pro Thr Asn Leu Phe Asp Glu Arg Leu Thr Val 
    770                 775                 780                 


Leu Leu Arg His Asp Leu Asp Glu Arg Gln Ile Ser Tyr Pro Ser Asn 
785                 790                 795                 800 


Ser Tyr Asp Asn Glu Leu Phe Lys Ile Trp Trp Lys Ser Arg Ser Asp 
                805                 810                 815     


Ser Thr Gln Ser Phe Tyr Asn Ala Glu Arg Glu Tyr Val Ile Phe Gly 
            820                 825                 830         


Glu Lys Val Asn Phe Met Pro Asn Thr Lys Asp Asn Phe Ala Asp Tyr 
        835                 840                 845             


Tyr Gln His Ala Phe Thr Thr Ala Tyr Gln Lys Lys Arg Lys Glu Arg 
    850                 855                 860                 


Thr Leu Gln Gln Lys Glu Asp Arg Arg Leu Pro Asn Ile Gln Leu Glu 
865                 870                 875                 880 


Gln Val Glu Lys Thr Phe Lys Gln Thr Ile Ala Gly Thr Glu Lys Glu 
                885                 890                 895     


Ile Arg Met Leu Gln Glu Glu Asp Arg Ile Met Leu Leu Met Ile Glu 
            900                 905                 910         


Ser Leu Leu Glu Asp Gly Lys Lys Met Gln Leu Lys Leu Ser Glu Ile 
        915                 920                 925             


Asp Thr Leu Leu Asn Ala Ala Thr Glu Val Lys Gln Thr Val Ser Ala 
    930                 935                 940                 


Lys Leu Ser Phe Asn Asp Ser Gly Glu Leu Ile Lys Asp Lys Thr Asn 
945                 950                 955                 960 


Pro Ala Ile Val Arg Thr Ile Thr Val Ser Arg Lys Arg Lys Asp Tyr 
                965                 970                 975     


Ser Met Leu Arg Lys Phe Ile Phe Asp Arg Arg Leu Pro Glu Leu Phe 
            980                 985                 990         


Glu Tyr Phe Pro Glu Lys Glu Ile  Gln Leu Asp Ser Leu  Lys Glu Glu 
        995                 1000                 1005             


Leu Asp  Ala Tyr Asn Lys Ala  Lys His Glu Val Phe  Asp Val Val 
    1010                 1015                 1020             


Phe Glu  Leu Glu Ala Lys Ile  Ile Ala Lys Asp Ser  Asp Gly Ile 
    1025                 1030                 1035             


Gln Gln  Leu Phe Ala Asp Glu  Ser Gly Lys Pro Leu  Thr Gly Asn 
    1040                 1045                 1050             


Ile Gln  His Lys Pro Tyr Leu  Thr Trp Leu Lys Asn  Lys Gly Leu 
    1055                 1060                 1065             


Leu Asp  Asp Asn Thr Phe Thr  Phe Leu Asn Met Val  Arg Asn Cys 
    1070                 1075                 1080             


Phe Ser  His Asn Gln Tyr Pro  Gln Lys Lys Thr Met  Glu Arg Leu 
    1085                 1090                 1095             


Ile His  His Trp Glu Pro Asn  Arg Phe Ala Leu Thr  Ile Ala Ser 
    1100                 1105                 1110             


Lys Tyr  Lys Gln Glu Ile Ala  Arg Ile Met Glu Asp  Leu 
    1115                 1120                 1125     


<210>  2716
<211>  1141
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2716

Met Glu Asp Asp Lys Lys Thr Thr Glu Ser Thr Asn Met Leu Asp Asn 
1               5                   10                  15      


Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn Val Tyr 
            20                  25                  30          


Ile Thr Val Asn His Ile Asn Lys Val Leu Glu Leu Lys Asn Lys Lys 
        35                  40                  45              


Asp Gln Asp Ile Ile Ile Asp Asn Asp Gln Asp Ile Leu Ala Ile Lys 
    50                  55                  60                  


Thr His Trp Glu Lys Val Asn Gly Asp Leu Asn Lys Thr Glu Arg Leu 
65                  70                  75                  80  


Arg Glu Leu Met Thr Lys His Phe Pro Phe Leu Glu Thr Ala Ile Tyr 
                85                  90                  95      


Thr Lys Asn Lys Glu Asp Lys Glu Glu Val Lys Gln Glu Lys Gln Ala 
            100                 105                 110         


Lys Ala Gln Ser Phe Asp Ser Leu Lys His Cys Leu Phe Leu Phe Leu 
        115                 120                 125             


Glu Lys Leu Gln Glu Ala Arg Asn Tyr Tyr Ser His Tyr Lys Tyr Ser 
    130                 135                 140                 


Glu Ser Thr Lys Glu Pro Met Leu Glu Lys Glu Leu Leu Lys Lys Met 
145                 150                 155                 160 


Tyr Asn Ile Phe Asp Asn Asn Ile Gln Leu Val Ile Lys Asp Tyr Gln 
                165                 170                 175     


His Asn Lys Asp Ile Asn Pro Asp Glu Asp Phe Lys His Leu Asp Arg 
            180                 185                 190         


Thr Glu Glu Glu Phe Asn Tyr Tyr Phe Thr Arg Asn Lys Lys Gly Asn 
        195                 200                 205             


Ile Thr Ala Ser Gly Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys 
    210                 215                 220                 


Lys Asp Ala Ile Trp Met Gln Gln Lys Leu Arg Gly Phe Lys Asp Asn 
225                 230                 235                 240 


Arg Glu Ser Lys Lys Lys Met Thr His Glu Val Phe Cys Arg Arg Arg 
                245                 250                 255     


Met Leu Leu Pro Lys Leu Arg Leu Glu Ser Thr Gln Thr Gln Asp Trp 
            260                 265                 270         


Ile Leu Leu Asp Met Leu Asn Glu Leu Ile Arg Cys Pro Lys Ser Leu 
        275                 280                 285             


Tyr Glu Arg Leu Gln Gly Glu Asp Arg Glu Lys Phe Lys Val Pro Phe 
    290                 295                 300                 


Asp Pro Ala Asp Glu Asp Tyr Asp Ala Glu Gln Glu Pro Phe Lys Asn 
305                 310                 315                 320 


Thr Leu Val Arg His Gln Asp Arg Phe Pro Tyr Phe Ala Leu Arg Tyr 
                325                 330                 335     


Phe Asp Tyr Asn Glu Ile Phe Thr Asn Leu Arg Phe Gln Ile Asp Leu 
            340                 345                 350         


Gly Thr Tyr His Phe Ser Ile Tyr Lys Lys Leu Ile Gly Gly Gln Lys 
        355                 360                 365             


Glu Asp Arg His Leu Thr His Lys Leu Tyr Gly Phe Glu Arg Ile Gln 
    370                 375                 380                 


Glu Phe Ala Lys Gln Asn Arg Thr Asp Glu Trp Lys Ala Ile Val Lys 
385                 390                 395                 400 


Asp Leu Asp Thr Tyr Glu Thr Ser Asn Glu Arg Tyr Ile Ser Glu Thr 
                405                 410                 415     


Ile Pro His Tyr His Leu Glu Asn Gln Lys Ile Gly Ile Arg Phe Arg 
            420                 425                 430         


Asn Asp Asn Asp Glu Ile Trp Pro Ser Leu Lys Thr Asn Gly Glu Asn 
        435                 440                 445             


Asn Glu Lys Arg Lys Tyr Lys Leu Asp Lys Gln Tyr Gln Ala Glu Ala 
    450                 455                 460                 


Phe Leu Ser Val His Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu 
465                 470                 475                 480 


Leu Lys Met Glu Asn Thr Asp Asn Gly Lys Glu Asn Asn Glu Val Gly 
                485                 490                 495     


Thr Lys Lys Lys Arg Asn Lys Asn Asn Glu Gln Glu Lys His Lys Ile 
            500                 505                 510         


Glu Glu Ile Ile Glu Asn Lys Ile Lys Asp Ile Tyr Ala Leu Tyr Asp 
        515                 520                 525             


Ala Phe Ala Asn Gly Glu Ile Asn Ser Glu Glu Glu Leu Lys Glu Tyr 
    530                 535                 540                 


Leu Lys Gly Lys Asp Ile Glu Ile Val His Leu Pro Lys Gln Met Ile 
545                 550                 555                 560 


Ala Ile Leu Glu Ser Lys Pro Lys Asp Met Val Lys Glu Ala Lys Arg 
                565                 570                 575     


Lys Gln Lys Glu Met Val Lys Asp Thr Lys Lys Leu Leu Ala Ala Leu 
            580                 585                 590         


Glu Lys Gln Thr Gln Gly Glu Ile Glu Asp Gly Gly Arg Asn Ile Arg 
        595                 600                 605             


Leu Leu Lys Ser Gly Glu Ile Ala Arg Trp Leu Val Asn Asp Met Met 
    610                 615                 620                 


Arg Phe Gln Pro Val Gln Lys Asp Asn Glu Gly Asn Pro Leu Asn Asn 
625                 630                 635                 640 


Ser Lys Ala Asn Ser Thr Glu Tyr Gln Met Leu Gln Arg Ser Leu Ala 
                645                 650                 655     


Leu Tyr Asn Lys Glu Glu Lys Pro Thr Arg Tyr Phe Arg Gln Val Asn 
            660                 665                 670         


Leu Ile Asn Ser Ser Asn Pro His Pro Phe Leu Lys Trp Thr Lys Trp 
        675                 680                 685             


Glu Glu Cys Asn Asn Ile Leu Ser Phe Tyr Arg Ser Tyr Leu Thr Lys 
    690                 695                 700                 


Lys Ile Glu Phe Leu Asn Lys Leu Lys Pro Glu Glu Trp Lys Lys Asn 
705                 710                 715                 720 


Gln Tyr Phe Leu Lys Leu Lys Glu Pro Lys Thr Asn Arg Glu Thr Leu 
                725                 730                 735     


Val Gln Gly Trp Lys Asn Gly Phe Asn Leu Pro Arg Gly Ile Phe Thr 
            740                 745                 750         


Glu Pro Ile Arg Glu Trp Phe Lys Arg His Gln Asn Asp Ser Lys Glu 
        755                 760                 765             


Tyr Glu Lys Val Glu Ala Leu Asp Arg Val Gly Leu Val Ala Lys Val 
    770                 775                 780                 


Ile Pro Leu Phe Phe Lys Glu Glu Tyr Phe Lys Glu Asp Ala Gln Lys 
785                 790                 795                 800 


Glu Ile Asn Asn Cys Val Gln Pro Phe Tyr Ser Phe Pro Tyr Asn Val 
                805                 810                 815     


Gly Asn Ile His Lys Pro Asp Glu Lys Asp Phe Leu Pro Ser Glu Glu 
            820                 825                 830         


Arg Lys Lys Arg Trp Gly Asp Lys Lys Tyr Lys Phe Lys Gly Tyr Lys 
        835                 840                 845             


Ala Lys Val Lys Ser Lys Lys Leu Thr Asp Lys Glu Lys Glu Glu Tyr 
    850                 855                 860                 


Arg Ser Tyr Leu Glu Phe Gln Ser Trp Asn Lys Phe Glu Arg Glu Leu 
865                 870                 875                 880 


Arg Leu Val Arg Asn Gln Asp Ile Val Thr Trp Leu Leu Cys Thr Glu 
                885                 890                 895     


Leu Ile Asp Lys Leu Lys Val Glu Gly Leu Asn Val Glu Glu Leu Gln 
            900                 905                 910         


Lys Leu Arg Leu Lys Asp Ile Asp Thr Asp Thr Ala Lys Gln Glu Lys 
        915                 920                 925             


Asn Asn Ile Leu Asn Arg Ile Met Pro Met Gln Leu Pro Val Thr Val 
    930                 935                 940                 


Tyr Glu Ile Asp Asp Ser His Asn Ile Val Lys Asp Lys Pro Leu His 
945                 950                 955                 960 


Thr Val Tyr Ile Glu Glu Thr Lys Thr Lys Leu Leu Lys Gln Gly Asn 
                965                 970                 975     


Phe Lys Ala Leu Val Lys Asp Arg Arg Leu Asn Gly Leu Phe Ser Phe 
            980                 985                 990         


Val Asp Thr Ser Ser Lys Ala Glu  Leu Lys Asp Lys Pro  Ile Ser Lys 
        995                 1000                 1005             


Ser Val  Val Glu Tyr Glu Leu  Gly Glu Tyr Gln Asn  Ala Arg Ile 
    1010                 1015                 1020             


Glu Thr  Ile Lys Asp Met Leu  Leu Leu Glu Glu Thr  Leu Ile Lys 
    1025                 1030                 1035             


Lys Tyr  Lys Thr Leu Pro Thr  Asn Lys Phe Ser Ala  Met Leu Asn 
    1040                 1045                 1050             


Gly Trp  Leu Glu Gly Lys Asp  Glu Ala Asp Lys Ala  Arg Phe Gln 
    1055                 1060                 1065             


Asn Asp  Val Lys Leu Leu Val  Ala Val Arg Asn Ala  Phe Ser His 
    1070                 1075                 1080             


Asn Gln  Tyr Pro Met Arg Asn  Arg Ile Ala Phe Ala  Asn Ile Asn 
    1085                 1090                 1095             


Pro Phe  Ser Leu Ser Ser Ala  Asn Thr Ser Glu Glu  Lys Lys Leu 
    1100                 1105                 1110             


Asp Ile  Ala Asn Gln Leu Lys  Asp Lys Thr His Lys  Thr Ile Glu 
    1115                 1120                 1125             


Lys Ile  Ile Glu Ile Glu Lys  Pro Ile Glu Thr Lys  Glu 
    1130                 1135                 1140     


<210>  2717
<211>  1144
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2717

Met Asn Asn Leu Cys Asn Gln Ser Pro Arg Glu Val Tyr Asn Leu Lys 
1               5                   10                  15      


Asp Ser Pro Trp Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg His Asn 
            20                  25                  30          


Ile Tyr Leu Ile Ser Asn Glu Ile Ser Asp Lys Leu Ser Leu Lys His 
        35                  40                  45              


Pro Leu Ser Asn Glu Glu Ile Ile Glu Lys Ser Phe Leu Thr Asp Lys 
    50                  55                  60                  


Asp Phe Trp Asn Lys Asn Asn Pro Arg Leu Ile Leu Ser Ala Leu Ser 
65                  70                  75                  80  


Arg Phe Met Pro Val Val Lys Thr Tyr Ser Ser Asp Leu Leu His Lys 
                85                  90                  95      


Glu Leu Arg Glu Gln Thr Asp Ile Glu Gly Thr Asp Ile Ala Gly Leu 
            100                 105                 110         


Val Glu Phe Leu Arg Leu Ser Phe Lys Glu Leu Asn Ala Phe Arg Asn 
        115                 120                 125             


Asp Tyr Ser His Tyr Tyr Ser Ser Lys Thr Tyr Asp Lys Arg Lys Val 
    130                 135                 140                 


Val Val Ala Glu Asp Phe Ala Ile Met Leu Arg Lys Gln Phe Gln Leu 
145                 150                 155                 160 


Ala Val Ser Ile Ala Arg Lys Arg Phe Glu Gly Val Ile Pro Ala Lys 
                165                 170                 175     


Ser Phe Asp Phe Val Glu Lys Lys Ile Ala Glu Glu Leu Phe Asn Asp 
            180                 185                 190         


Ser Thr Thr Ile Thr Thr Arg Gly Leu Val Phe Phe Thr Cys Leu Phe 
        195                 200                 205             


Leu Asp Lys Glu Asn Ala Phe Gln Phe Phe Asn Lys Val Ser Gly Phe 
    210                 215                 220                 


Lys Asp Thr Arg Thr Tyr Glu Phe Leu Ala Thr Arg Glu Val Phe Thr 
225                 230                 235                 240 


Met Phe Cys Val Lys Leu Pro His Asp Lys Phe Val Ser Glu Asn Pro 
                245                 250                 255     


Gln Gln Ala Leu Gln Leu Asp Ile Leu Asn Tyr Leu Asn Arg Ala Pro 
            260                 265                 270         


Ile Glu Leu Tyr Asn Ser Leu Thr Glu Glu Gly Lys Lys Ile Phe Gln 
        275                 280                 285             


Pro Asp Leu Ser Glu Phe Ala Lys Ile Asn Ile Ala Glu Asn Ser Ile 
    290                 295                 300                 


Asn Glu Thr Ile Ser Glu Tyr Asp Tyr Asp Glu Tyr Ile Gln Ala Ile 
305                 310                 315                 320 


Thr Thr Lys Thr Arg Ser Glu Asp Arg Phe Pro Glu Phe Ala Leu Arg 
                325                 330                 335     


Tyr Leu Asp Gln Ser Asp Ala Phe Gln Tyr His Phe His Ile His Leu 
            340                 345                 350         


Gly Lys Val Ile Thr Asn Lys Tyr Pro Lys Pro Phe Leu Gly Glu Ser 
        355                 360                 365             


Pro Asp Glu Asp Asn Arg Asn Ile Glu Lys Ser Ile Lys Thr Phe Gly 
    370                 375                 380                 


Glu Leu Thr Ala Phe Leu Lys Pro His Gln Thr Asp Thr Glu Gly Val 
385                 390                 395                 400 


Lys Asn Ser Ile Ile Gln Glu Asp Glu Phe Lys Lys Leu Phe Gln Glu 
                405                 410                 415     


Gln Gly Leu Val Gly Phe Thr Gln Tyr Ala Pro His Tyr His Ile Gln 
            420                 425                 430         


Asn Asn Lys Ile Gly Leu Leu Asp Lys Leu Asn Glu Gln Val Ser Lys 
        435                 440                 445             


Leu Pro Cys Asn Leu Tyr Arg Pro Leu Pro Pro Val Ala Phe Leu Ser 
    450                 455                 460                 


Ile His Glu Leu Pro Lys Val Val Leu Leu Glu Ile Leu Ala Lys Gly 
465                 470                 475                 480 


Lys Ala Ser Lys Leu Ile Thr Asp Phe Leu Gln Lys Asn Lys Glu Leu 
                485                 490                 495     


Ile Tyr Asn Arg Asp Phe Ile Glu Asp Ile Lys Lys Gln Leu Asp Phe 
            500                 505                 510         


Lys Pro Leu Gln Lys Leu Phe Phe Asp Glu Lys Ser Pro Lys Leu Val 
        515                 520                 525             


Asn Asn Glu Glu Thr Glu Arg Lys Ile Glu Glu Thr Gln Asn Gln Leu 
    530                 535                 540                 


Lys Gln Ser Ile Pro Glu Lys Gln Lys Val Lys Leu Lys Ser Thr Leu 
545                 550                 555                 560 


Lys Ser Leu Ile Tyr Ala Arg Tyr Val Asn Glu Val Asn Glu Arg Lys 
                565                 570                 575     


Ala Lys Leu Asn Leu Leu Leu Ala Glu Arg Lys Leu Asp Ala Asn Gln 
            580                 585                 590         


Ile Pro Gly Arg Ile Ile Glu Tyr Trp Leu Asn Ile Asp Ser Val Lys 
        595                 600                 605             


Lys Glu His Ser Ile Gln Asn Arg Ile Lys Ala Glu Arg Lys Glu Cys 
    610                 615                 620                 


Lys Asn Arg Ile Lys Asp Leu Asp Lys Gly Lys Ala Pro Lys Ile Gly 
625                 630                 635                 640 


Glu Met Ala Thr Phe Leu Ala Arg Asp Ile Val Lys Leu Val Ile Asn 
                645                 650                 655     


Lys Asp Val Lys Lys Lys Ile Thr Ser Phe Tyr Tyr Asn Leu Leu Gln 
            660                 665                 670         


Glu Cys Leu Ala Leu Tyr Ala Asp Pro Thr Lys Arg Gln Leu Leu Leu 
        675                 680                 685             


Asp Leu Cys Gly Lys Lys Leu Asn Leu Phe Asn Lys Glu Ile Gly His 
    690                 695                 700                 


Pro Phe Leu Ala Asp Ile Asn Phe Gly Glu Ile Thr Lys Thr Lys Asp 
705                 710                 715                 720 


Leu Tyr Arg Lys Tyr Leu Glu Leu Lys Gly Ala Gly Lys Lys Val Glu 
                725                 730                 735     


Lys Lys Tyr Asn Arg Lys Thr Asn Arg Phe Glu Glu Ile Glu Lys Glu 
            740                 745                 750         


Asp Asp Trp Ile Tyr Asn Thr Phe Tyr Phe Val Lys Lys Asp Pro Ile 
        755                 760                 765             


Thr Asn Lys Glu Phe Thr Lys Ile Lys Leu Pro Glu Ser Asn Val Pro 
    770                 775                 780                 


Leu Ser Tyr Leu Arg Phe Asn Gln Asp Lys Thr Ser Phe Asp Phe Trp 
785                 790                 795                 800 


Leu Asn Ser Val Ser Lys Gly Asn Asn Lys Asn Pro Asn Pro Lys Pro 
                805                 810                 815     


Val Asp Leu Pro Thr Asn Leu Phe Asp Asn Val Leu Ile Ser Ile Leu 
            820                 825                 830         


Lys Arg Lys Val Glu Ile Ser Asp Asp Thr Lys Tyr Asn Tyr Ser Lys 
        835                 840                 845             


Leu Leu Ala Leu Trp Leu Lys Glu Thr Gln Pro Tyr Tyr His Leu Lys 
    850                 855                 860                 


Arg Glu Tyr Thr Ile Phe Lys Asp Lys Pro Tyr Gln Thr Ile Val Glu 
865                 870                 875                 880 


Phe Asp Pro Asn Glu Asn Lys Pro Phe Lys Glu Tyr Tyr Ala Asn Ser 
                885                 890                 895     


Val Glu His Ala Phe Arg Lys Arg Lys Arg Glu Glu Lys Arg Ile Gln 
            900                 905                 910         


Lys Arg Gln Ile Ala Thr Val Phe Lys Lys Ala Ile Glu Asp Asn Glu 
        915                 920                 925             


Lys Val Ile Arg Phe Tyr Gln Thr Lys Asp Arg Ile Thr Leu Leu Met 
    930                 935                 940                 


Leu Asn Glu Leu Met Gly Lys Asp Leu Gln Ile Ser Leu Asn Glu Leu 
945                 950                 955                 960 


Ser Pro Asp Ser Asp Lys Ser Pro Leu Glu Ala His Ile Thr Ile Cys 
                965                 970                 975     


Glu Lys Ile His Gly Lys Thr Ile Thr Asp Arg Arg Lys Arg Lys Asp 
            980                 985                 990         


Phe Ser Val Phe Arg Lys Leu Ile  Ser Asp Arg Arg Leu  Lys His Leu 
        995                 1000                 1005             


Phe Asp  Tyr Tyr Ser Ser Glu  Thr Ile Pro Tyr Glu  Val Leu Arg 
    1010                 1015                 1020             


Glu Glu  Leu Asn Asp Tyr Asp  Arg Cys Lys Glu Lys  Val Phe Lys 
    1025                 1030                 1035             


Ala Ala  Phe Asp Leu Glu Lys  Ala Ile Ile Asn Val  Ala Ser Lys 
    1040                 1045                 1050             


Glu Glu  Tyr Gln Lys Ile Val  Glu Asp Gly Thr Lys  Tyr Gly Ala 
    1055                 1060                 1065             


Asn Ile  Gln His Arg Pro Tyr  Leu Asp Trp Leu Thr  Ser His Asn 
    1070                 1075                 1080             


Ala Ile  Ser Lys Ile Glu Glu  Lys Phe Leu Leu Glu  Val Arg Asn 
    1085                 1090                 1095             


Arg Phe  Ser His Asn Glu Tyr  Pro Lys Lys Asp Ile  Val Thr Lys 
    1100                 1105                 1110             


Tyr Ile  Pro His Phe Ala Asn  Ser Thr Ile Ser Ser  Lys Ile Val 
    1115                 1120                 1125             


Ala Thr  Tyr Val Glu Ile Val  Asn Arg Leu Ile Thr  Thr Ile Leu 
    1130                 1135                 1140             


Arg 
    


<210>  2718
<211>  1131
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2718

Met Glu Lys Thr Ile Glu Asn Gln Thr Gln Ser Lys Arg Thr Leu Asn 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Asp Glu Glu Lys Ile Thr Thr Ser Phe Leu Val Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Arg Gln Ser Leu Val Tyr Ser Asn Leu Thr 
65                  70                  75                  80  


Arg Tyr Met His Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Asp 
                85                  90                  95      


Asp Glu Arg Asp Lys Ala Glu Asn Tyr Gly Lys Asp Phe Gly Asn Leu 
            100                 105                 110         


Thr Asp Thr Leu Lys Glu Ile Phe Lys Glu Leu Asn Glu Phe Arg Asn 
        115                 120                 125             


Asp Tyr Ser His Tyr Tyr Ser Thr Glu Lys Lys Asp Lys Arg Lys Thr 
    130                 135                 140                 


Ile Val Ser Asp Lys Leu Lys Asn Phe Leu Asn Ile Asn Tyr Thr Arg 
145                 150                 155                 160 


Ala Ile Lys Tyr Thr Lys Ser Arg Phe Ile Asn Val Phe Ser Asp Asn 
                165                 170                 175     


Asn Phe Cys Leu Ala Glu Glu Ala Lys His Val Glu Asn Asp Asn Thr 
            180                 185                 190         


Ile Thr Gln Asp Gly Ile Val Phe Phe Thr Ser Met Phe Leu Asp Arg 
        195                 200                 205             


Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile Ile Gly Leu Lys Gly Thr 
    210                 215                 220                 


Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Thr Leu Met Ala Phe Cys 
225                 230                 235                 240 


Val Asn Leu Pro His Asp Lys Phe Val Ser Glu Asn Ser Glu Gln Gln 
                245                 250                 255     


Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu 
            260                 265                 270         


Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln His Phe Leu Pro Lys Leu 
        275                 280                 285             


Asp Asp Glu Gln Ile Asp Asn Val Leu Glu Asn Ser Val Pro Tyr Thr 
    290                 295                 300                 


Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn Ile Thr Lys Lys Val Arg 
305                 310                 315                 320 


Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu Lys Phe Ile Asp Gln Lys 
                325                 330                 335     


Lys Leu Phe Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val 
            340                 345                 350         


Leu Asp Glu Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Lys Arg Thr 
        355                 360                 365             


Val Thr Glu Asn Thr Lys Ala Phe Gly Met Leu Gln Asp Leu Asn Asp 
    370                 375                 380                 


Glu Glu Asn Val Leu Asn Lys Ile Asn Thr Gly Glu Ser Lys Ala Lys 
385                 390                 395                 400 


Phe Asp Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Thr Lys Asn 
            420                 425                 430         


Thr Asp Asn Lys Ile Lys Ser Asn Leu Leu Gln Pro Leu Pro Glu Ala 
        435                 440                 445             


Phe Leu Ser Ile Asn Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
    450                 455                 460                 


Glu Gln Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn 
465                 470                 475                 480 


Asn Ser Lys Ile Leu Asn Lys Glu Phe Ile Lys Ala Ile Lys Leu Lys 
                485                 490                 495     


Leu Asn Asp Leu Asp Val Phe Tyr Lys Arg Ser Gln Gly Arg Lys Gln 
            500                 505                 510         


Lys His Ala Tyr Leu Thr Lys Asp Lys Lys Tyr Asp Asn Glu Lys Ile 
        515                 520                 525             


Asn Glu Leu Lys Asn Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu 
    530                 535                 540                 


Tyr Asn Leu Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp 
545                 550                 555                 560 


Leu Asn Ile Ala Asp Val Gln Ala Lys Asn Ala Ile Ser Asp Arg Ile 
                565                 570                 575     


Lys Leu Met Lys Arg Asp Cys Ile Asn Arg Leu Lys Ser Met Lys Lys 
            580                 585                 590         


Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp 
        595                 600                 605             


Ile Val Asp Met Ile Ile Asp Glu Glu Lys Lys Lys Lys Ile Thr Ser 
    610                 615                 620                 


Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Lys 
625                 630                 635                 640 


Glu Lys Lys Glu Leu Phe Ile Leu Ile Cys Asn Asn Glu Leu Lys Leu 
                645                 650                 655     


Asn Asp Asp Asp Gly His Pro Phe Phe Lys Asn Ile Asn Phe Ser Asn 
            660                 665                 670         


Tyr Lys Tyr Thr Ser Glu Ile Tyr Gln Lys Tyr Leu Glu Glu Lys Gly 
        675                 680                 685             


His Lys Met Val Lys Glu Tyr Asn Pro Arg Lys Glu Asn Tyr Val Glu 
    690                 695                 700                 


Lys Asp Lys Ser Trp Leu Glu Ile Asn Phe Tyr Lys Lys Glu Trp Asn 
705                 710                 715                 720 


Glu Asn Ala Lys Lys Asp Leu Thr Val Val Lys Leu Pro Asp Asp Lys 
                725                 730                 735     


Ser Lys Ile Pro Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser 
            740                 745                 750         


Phe Glu Asn Trp Phe Lys Tyr Val Thr Asn Gly Lys Glu Thr Thr Asp 
        755                 760                 765             


Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp Glu Thr Leu 
    770                 775                 780                 


Lys Glu Leu Leu Lys Lys Glu Leu Ser Lys Asn Asn Ile Glu Phe Lys 
785                 790                 795                 800 


Glu Glu Asp Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Asp Lys Cys 
                805                 810                 815     


Arg Asn Asp Lys Thr Gln Lys Phe Tyr Ser Ala Glu Arg Glu Tyr Thr 
            820                 825                 830         


Phe Glu Glu Glu Lys Leu Asn Phe His Ile Asn Thr Lys Ser Lys Phe 
        835                 840                 845             


Glu Glu Tyr Ile Asn Pro Glu Phe Ala Glu Lys Val Phe Arg Leu Lys 
    850                 855                 860                 


Asn Gln Asn Arg Glu Lys Asp Asn Ile Ser Gly Arg Arg Leu Pro Pro 
865                 870                 875                 880 


Leu Lys Met Lys Glu Val Thr Lys Asn Met Val Lys Arg Ile Gly Asn 
                885                 890                 895     


Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Leu Met Leu 
            900                 905                 910         


Leu Met Phe Glu Lys Leu Val Asp Asn Asn Leu Lys Leu Lys Leu Glu 
        915                 920                 925             


Asn Val Asp Lys Leu Leu Asn Glu Ser Ile Glu Ile Asn Gln Ser Ile 
    930                 935                 940                 


Ser Gly Lys Leu Ser Phe Asp Asp Ser Gly Asp Asn Glu Asn Lys Lys 
945                 950                 955                 960 


Asp Arg Ala Ile Ile Cys Arg Asn Ile Thr Glu Thr Arg Lys Arg Lys 
                965                 970                 975     


Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Glu Glu Glu  Asn Ile Pro Ile Glu  Lys Ile Lys 
        995                 1000                 1005             


Ile Glu  Leu Asp Thr Tyr Ser  Lys Ala Lys Asp Val  Val Phe Asp 
    1010                 1015                 1020             


Leu Ile  Phe Asp Leu Glu Arg  Ala Ile Ile Asn Lys  Asp Glu Asn 
    1025                 1030                 1035             


Arg Ile  Lys Glu Leu Asn Lys  Asp Lys Asn Gly Val  Ile Gln Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Phe Trp Leu  Leu Glu Lys 
    1055                 1060                 1065             


Asn Leu  Ile Thr Glu Gln Glu  Phe Thr Phe Met Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Thr  Phe Ser His Asn Gln  Phe Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Leu Phe  Ile Lys Asn Trp Asn  Glu Asn Glu Phe Ala  Lys Gln Ile 
    1100                 1105                 1110             


Leu Asn  Val Tyr Asn Gln Lys  Asn Asn Asn Leu Ile  Lys Ser Ile 
    1115                 1120                 1125             


Lys Asp  Ile 
    1130     


<210>  2719
<211>  1081
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2719

Met Lys Lys Thr Asn Thr Tyr Phe Asp Phe Lys Asp Lys Thr Gln Lys 
1               5                   10                  15      


Tyr Phe Phe Ala Gly Leu Phe Asn Thr Ala Leu Asn Asn Phe Asp Leu 
            20                  25                  30          


Ser Leu Asp Glu Leu Ala Asn Arg Thr Gly Leu Lys Cys Asn Gly Lys 
        35                  40                  45              


Glu Leu Ile Ala Val Ala Phe Asn Asp Thr Cys Ser Gln Thr Asp Tyr 
    50                  55                  60                  


Asn Asn Arg Leu Ser Tyr Leu Ser Glu Ser Leu Ala Phe Ile Glu Leu 
65                  70                  75                  80  


Ile Lys Thr Lys Glu Arg Ser Tyr Ile Arg Leu His Leu Thr Glu Leu 
                85                  90                  95      


Tyr Asn Leu Ile Asp Asn Tyr Arg Asn Tyr Phe Thr His Leu Glu His 
            100                 105                 110         


Pro Asp Leu Ile Ile Lys Pro Leu Ile Phe Glu Leu Leu Asp Leu Phe 
        115                 120                 125             


Ile Leu Glu Ser Ala Lys Thr Val Lys Lys Glu Arg Val Lys Thr Glu 
    130                 135                 140                 


Glu Asn Lys Ser Tyr Leu Ser Lys Lys Phe Lys Leu Glu Ile Thr Ser 
145                 150                 155                 160 


Thr Phe Glu Ala Ala Asn Asn Ala Ile Asn Leu Glu Asn Lys Asn Asn 
                165                 170                 175     


Pro His Ser Lys Thr His Lys Lys Leu Ile Thr Gln Asn Asp Lys Ile 
            180                 185                 190         


Asn Phe Val Leu Ile Asn Ala Phe Tyr Asn Phe Leu Ile Asn Thr Asp 
        195                 200                 205             


Glu Ile Pro Thr Leu Lys Glu Thr Ala Arg Ser Ile Asn Lys Asp Thr 
    210                 215                 220                 


Gly Gln Ile Ser Gln Asn Gly Ile Ile Gln Leu Leu Ala Ile Phe Leu 
225                 230                 235                 240 


Asn Lys Lys Gln Leu Glu Ile Leu Phe Asp Asn Thr His Tyr Leu Lys 
                245                 250                 255     


Gly Thr Leu Lys Leu Asn His Leu Cys Thr Arg Trp Thr Tyr Ser Gln 
            260                 265                 270         


Leu Ala Tyr Arg Asn Ile Lys Lys Leu Leu Lys Ser Asp Tyr Ser Asn 
        275                 280                 285             


Asp Ser Leu Ile Leu Gln Met Leu Ser Glu Leu Thr Lys Cys Pro Lys 
    290                 295                 300                 


His Leu Tyr Pro Asn Leu Pro Asn Asn Ser Lys Gln Glu Phe Ile Glu 
305                 310                 315                 320 


Asp Leu Asn Glu Tyr Leu Lys Glu Thr Glu Tyr Phe Lys Asp Ser Ile 
                325                 330                 335     


Ala Gln Glu Thr Val Ser Asn Glu Val Ile Arg Lys Arg Tyr Glu Asp 
            340                 345                 350         


Lys Phe Pro Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe Ile Asp Phe 
        355                 360                 365             


Pro Asn Leu Arg Phe Gln Ile Asn Leu Gly Lys Phe Asn His Asn Thr 
    370                 375                 380                 


Cys Leu Lys Lys Phe Glu Asn Thr Ala Val Tyr Thr Glu Arg Gln Ile 
385                 390                 395                 400 


Leu Glu Lys Leu Thr Ile Phe Glu Lys Leu Thr Leu Ala Thr Asn Lys 
                405                 410                 415     


Lys Thr Glu Tyr Phe Leu Asn Asn Asn Leu Pro Asp Ser Glu Gly Trp 
            420                 425                 430         


Gln Glu Tyr Pro Lys Pro Ser Tyr Gln Phe Tyr Asn Asn Asn Ile Gly 
        435                 440                 445             


Phe Trp Leu Gly Ile Lys Asn Gly Ala Val Thr Asp Ala Lys Glu Lys 
    450                 455                 460                 


Arg Glu Asn Asp Lys Ser Ser Lys Phe Asp Ile Leu Lys Lys Ile Gly 
465                 470                 475                 480 


Leu Glu Cys Cys Leu Lys Lys Pro Val Ala Tyr Leu Ser Phe Asn Glu 
                485                 490                 495     


Leu Pro Ala Leu Leu Tyr Thr Val Leu Ile Glu Lys Lys Thr Ala Lys 
            500                 505                 510         


Glu Val Glu Arg Ile Phe Leu Lys Lys Ile Gly Glu Gln Thr Gly Ala 
        515                 520                 525             


Ile Asn Lys Phe Ala Asp Ile Asn Asn Phe Glu Lys Lys Ile Ile Pro 
    530                 535                 540                 


His Lys Phe Lys Glu Ile Leu Glu Asn Lys Glu Ser Asn Val Lys Trp 
545                 550                 555                 560 


Glu Lys Leu Lys Lys Asp Ile Glu Lys Glu Met Leu Ile Ser Pro Leu 
                565                 570                 575     


Asp Glu Ile Arg Ile His Tyr Lys Thr Ala Ser Lys His Pro Asn Asp 
            580                 585                 590         


Leu Ser Phe Ser Glu Lys Gly Lys Ile Ala Thr Trp Leu Ala His Asp 
        595                 600                 605             


Ile Lys Arg Phe Val Lys Ala Glu Thr Lys Lys Asp Trp Lys Gly Tyr 
    610                 615                 620                 


Gln Phe Ser Glu Phe Gln Ser Leu Leu Ala Tyr Tyr Asp Leu Lys Lys 
625                 630                 635                 640 


Met Glu Leu Leu Asn Phe Val Asn Phe Val Leu Lys Ile Asn Ile Lys 
                645                 650                 655     


Gln Asp Ile Val Phe Glu Asp Ile Asp Phe Asn Gln Lys Thr Leu Tyr 
            660                 665                 670         


Asp Phe Tyr Lys Asn Tyr Leu Ser Asn Arg Lys Lys Phe Leu Glu Gly 
        675                 680                 685             


Asn Leu Tyr Ser Ile Asp Gln Lys Asp Glu Val Pro Ala Lys Leu Trp 
    690                 695                 700                 


Arg Lys Arg Glu Leu Ser Ile Phe Thr Gly Phe Asp Asp Lys Leu Tyr 
705                 710                 715                 720 


Lys Tyr Lys Asn Phe Lys Thr Tyr Lys Glu Asn Leu Met Asn Met Pro 
                725                 730                 735     


Leu Asn Leu Pro Arg Gly Ile Phe Ser Asp Lys Gln Thr Cys Tyr Asn 
            740                 745                 750         


Lys Asn Ser Gln Asn Asn Asn Glu Leu Ala Glu Trp Phe Thr Lys Ser 
        755                 760                 765             


Asn Asn Ile Asn Asp Phe Gln Lys Phe Tyr Ser Phe Thr Arg Phe Tyr 
    770                 775                 780                 


Glu Asn Cys Gln Leu Thr Leu Asn Pro Leu Lys Gly Leu Lys Glu Gln 
785                 790                 795                 800 


Asn Asn Asn Lys Gly Val Pro Lys Glu Val Tyr Lys Asn Glu Lys Asn 
                805                 810                 815     


Ile Arg Asn Thr Met Arg Gln Asp Phe Tyr Ile Phe Glu Met Val Lys 
            820                 825                 830         


Tyr Tyr Phe Lys Ile Asn Glu Ser Leu Lys Ser Asp Leu Asn Asp Leu 
        835                 840                 845             


Lys Leu Asn Thr Leu Phe Leu Thr Lys Gln Glu Lys Glu Asn Asn Leu 
    850                 855                 860                 


Lys Val Leu Asn Gln Gln His Ser Arg Ser Lys Gly Asp Lys Ser Glu 
865                 870                 875                 880 


Asn Ile Leu Asn Glu Asn Tyr Ile Leu Ser Lys His Ile Met Met Ser 
                885                 890                 895     


Ile Leu Glu Gly Lys Ile Gln Gly Met Val Ala Leu Lys Ser Val Gly 
            900                 905                 910         


Lys Tyr Arg Phe Leu Ser Gln Asp Lys Arg Val Lys Gln Leu Val Thr 
        915                 920                 925             


Tyr Ile Pro Asp Lys Ile Trp Ser Phe Glu Glu Ile Asn Ser Glu Ile 
    930                 935                 940                 


Asp Glu Tyr Asp Lys Ile Arg Ala Phe Ser Phe Phe Lys Ile Ile His 
945                 950                 955                 960 


Glu Ile Glu Glu Lys Ile Phe Asn Lys Ala Ile Asn Asn Lys Glu Glu 
                965                 970                 975     


Ser Tyr Leu Leu Val Asp Gly His Pro Asn Phe Lys Ala Tyr Ile Ile 
            980                 985                 990         


Tyr Tyr Phe Leu Lys Thr Gln Asp  Glu Lys Asp Phe Phe  Asn Lys Leu 
        995                 1000                 1005             


Asp Val  Lys Asn Val Asn Ile  Asn Asp Ile Ala Ile  Ser Lys Phe 
    1010                 1015                 1020             


Lys Leu  Leu Phe Leu Ile Ile  Lys Ile Arg Asn Lys  Ile Cys His 
    1025                 1030                 1035             


Asn Gln  Leu Ile Ser Ser Asp  Glu Phe Ile Phe Leu  Leu Glu Phe 
    1040                 1045                 1050             


Thr Pro  Ile Glu Pro Asp Glu  Leu Tyr Met Ser Tyr  Leu Leu Lys 
    1055                 1060                 1065             


Ala Tyr  Lys Lys Ile Val Asn  Ile Ser Trp Asn Leu  Val 
    1070                 1075                 1080     


<210>  2720
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2720

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2721
<211>  1131
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2721

Met Glu Lys Thr Ile Glu Asn Gln Thr Gln Ser Lys Arg Thr Leu Asn 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Asp Glu Glu Lys Ile Thr Thr Ser Phe Leu Val Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Arg Gln Ser Leu Val Tyr Ser Asn Leu Thr 
65                  70                  75                  80  


Arg Tyr Met His Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Asp 
                85                  90                  95      


Asp Glu Arg Asp Lys Ala Glu Asn Tyr Gly Lys Asp Phe Gly Asn Leu 
            100                 105                 110         


Thr Asp Thr Leu Lys Glu Ile Phe Lys Glu Leu Asn Glu Phe Arg Asn 
        115                 120                 125             


Asp Tyr Ser His Tyr Tyr Ser Thr Glu Lys Lys Asp Lys Arg Lys Thr 
    130                 135                 140                 


Ile Val Ser Asp Lys Leu Lys Asn Phe Leu Asn Ile Asn Tyr Thr Arg 
145                 150                 155                 160 


Ala Ile Lys Tyr Thr Lys Ser Arg Phe Ile Asn Val Phe Ser Asp Asn 
                165                 170                 175     


Asn Phe Cys Leu Ala Glu Glu Ala Lys His Val Glu Asn Asp Asn Thr 
            180                 185                 190         


Ile Thr Gln Asp Gly Ile Val Phe Phe Thr Ser Met Phe Leu Asp Arg 
        195                 200                 205             


Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile Ile Gly Leu Lys Gly Thr 
    210                 215                 220                 


Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Thr Leu Met Ala Phe Cys 
225                 230                 235                 240 


Val Asn Leu Pro His Asp Lys Phe Val Ser Glu Asn Ser Glu Gln Gln 
                245                 250                 255     


Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu 
            260                 265                 270         


Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln His Phe Leu Pro Lys Leu 
        275                 280                 285             


Asp Asp Glu Gln Ile Asp Asn Val Leu Glu Asn Ser Val Pro Tyr Thr 
    290                 295                 300                 


Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn Ile Thr Lys Lys Val Arg 
305                 310                 315                 320 


Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu Lys Phe Ile Asp Gln Lys 
                325                 330                 335     


Lys Leu Phe Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val 
            340                 345                 350         


Leu Asp Glu Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Lys Arg Thr 
        355                 360                 365             


Val Thr Glu Asn Thr Lys Ala Phe Gly Met Leu Gln Asp Leu Asn Asp 
    370                 375                 380                 


Glu Glu Asn Val Leu Asn Lys Ile Asn Thr Gly Glu Ser Lys Ala Lys 
385                 390                 395                 400 


Phe Asp Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Thr Lys Asn 
            420                 425                 430         


Thr Asp Asn Lys Ile Lys Ser Asn Leu Leu Gln Pro Leu Pro Glu Ala 
        435                 440                 445             


Phe Leu Ser Ile Asn Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
    450                 455                 460                 


Glu Gln Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn 
465                 470                 475                 480 


Asn Ser Lys Ile Leu Asn Lys Glu Phe Ile Lys Ala Ile Lys Leu Lys 
                485                 490                 495     


Leu Asn Asp Leu Asp Val Phe Tyr Lys Arg Ser Gln Gly Arg Lys Gln 
            500                 505                 510         


Lys His Ala Tyr Leu Thr Lys Asp Lys Lys Tyr Asp Asn Glu Lys Ile 
        515                 520                 525             


Asn Glu Leu Lys Asn Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu 
    530                 535                 540                 


Tyr Asn Leu Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp 
545                 550                 555                 560 


Leu Asn Ile Ala Asp Val Gln Ala Lys Asn Ala Ile Ser Asp Arg Ile 
                565                 570                 575     


Lys Leu Met Lys Arg Asp Cys Ile Asn Arg Leu Lys Ser Met Lys Lys 
            580                 585                 590         


Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp 
        595                 600                 605             


Ile Val Asp Met Ile Ile Asp Glu Glu Lys Lys Lys Lys Ile Thr Ser 
    610                 615                 620                 


Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Lys 
625                 630                 635                 640 


Glu Lys Lys Glu Leu Phe Ile Leu Ile Cys Asn Asn Glu Leu Lys Leu 
                645                 650                 655     


Asn Asp Asp Asp Gly His Pro Phe Phe Lys Asn Ile Asn Phe Ser Asn 
            660                 665                 670         


Tyr Lys Tyr Thr Ser Glu Ile Tyr Gln Lys Tyr Leu Glu Glu Lys Gly 
        675                 680                 685             


His Lys Met Val Lys Glu Tyr Asn Pro Arg Lys Glu Asn Tyr Val Glu 
    690                 695                 700                 


Lys Asp Lys Ser Trp Leu Glu Ile Asn Phe Tyr Lys Lys Glu Trp Asn 
705                 710                 715                 720 


Glu Asn Ala Lys Lys Asp Leu Thr Val Val Lys Leu Pro Asp Asp Lys 
                725                 730                 735     


Ser Lys Ile Pro Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser 
            740                 745                 750         


Phe Glu Asn Trp Phe Lys Tyr Val Thr Asn Gly Lys Glu Thr Thr Asp 
        755                 760                 765             


Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp Glu Thr Leu 
    770                 775                 780                 


Lys Glu Leu Leu Lys Lys Glu Leu Ser Lys Asn Asn Ile Glu Phe Lys 
785                 790                 795                 800 


Glu Glu Asp Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Asp Lys Cys 
                805                 810                 815     


Arg Asn Asp Lys Thr Gln Lys Phe Tyr Ser Ala Glu Arg Glu Tyr Thr 
            820                 825                 830         


Phe Glu Glu Glu Lys Leu Asn Phe His Ile Asn Thr Lys Ser Lys Phe 
        835                 840                 845             


Glu Glu Tyr Ile Asn Pro Glu Phe Ala Glu Lys Val Phe Arg Leu Lys 
    850                 855                 860                 


Asn Gln Asn Arg Glu Lys Asp Asn Ile Ser Gly Arg Arg Leu Pro Pro 
865                 870                 875                 880 


Leu Lys Met Lys Glu Val Thr Lys Asn Met Val Lys Arg Ile Gly Asn 
                885                 890                 895     


Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Leu Met Leu 
            900                 905                 910         


Leu Met Phe Glu Lys Leu Val Asp Asn Asn Leu Lys Leu Lys Leu Glu 
        915                 920                 925             


Asn Val Asp Lys Leu Leu Asn Glu Ser Ile Glu Ile Asn Gln Ser Ile 
    930                 935                 940                 


Ser Gly Lys Leu Ser Phe Asp Asp Ser Gly Asp Asn Glu Asn Lys Lys 
945                 950                 955                 960 


Asp Arg Ala Ile Ile Cys Arg Asn Ile Thr Glu Thr Arg Lys Arg Lys 
                965                 970                 975     


Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Glu Glu Glu  Asn Ile Pro Ile Glu  Lys Ile Lys 
        995                 1000                 1005             


Ile Glu  Leu Asp Thr Tyr Ser  Lys Ala Lys Asp Val  Val Phe Asp 
    1010                 1015                 1020             


Leu Ile  Phe Asp Leu Glu Arg  Ala Ile Ile Asn Lys  Asp Glu Asn 
    1025                 1030                 1035             


Arg Ile  Lys Glu Leu Asn Lys  Asp Lys Asn Gly Val  Ile Gln Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Phe Trp Leu  Leu Glu Lys 
    1055                 1060                 1065             


Asn Leu  Ile Thr Glu Gln Glu  Phe Thr Phe Met Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Thr  Phe Ser His Asn Gln  Phe Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Leu Phe  Ile Lys Asn Trp Asn  Glu Asn Glu Phe Ala  Lys Gln Ile 
    1100                 1105                 1110             


Leu Asn  Val Tyr Asn Gln Lys  Asn Asn Asn Leu Ile  Lys Ser Ile 
    1115                 1120                 1125             


Lys Asp  Ile 
    1130     


<210>  2722
<211>  1168
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2722

Met Glu Arg Ile Phe Gly His Cys Cys Pro His His Asp Ser Val Cys 
1               5                   10                  15      


Phe Val Arg Phe Leu Gly Thr Met Val Ser Asn Gln Asp Gly Arg Glu 
            20                  25                  30          


Asn Val Leu Asp Ile Leu Tyr Ile Ala Asp Arg Thr Arg Lys Leu Lys 
        35                  40                  45              


Pro Met Asn Thr Val Pro Ala Ser Glu Asn Lys Gly Gln Ser Arg Thr 
    50                  55                  60                  


Val Glu Asp Asp Pro Gln Tyr Phe Gly Leu Tyr Leu Asn Leu Ala Arg 
65                  70                  75                  80  


Glu Asn Leu Ile Glu Val Glu Ser His Val Arg Ile Lys Phe Gly Lys 
                85                  90                  95      


Lys Lys Leu Asn Glu Glu Ser Leu Lys Gln Ser Leu Leu Cys Asp His 
            100                 105                 110         


Leu Leu Ser Val Asp Arg Trp Thr Lys Val Tyr Gly His Ser Arg Arg 
        115                 120                 125             


Tyr Leu Pro Phe Leu His Tyr Phe Asp Pro Asp Ser Gln Ile Glu Lys 
    130                 135                 140                 


Asp His Asp Ser Lys Thr Gly Val Asp Pro Asp Ser Ala Gln Arg Leu 
145                 150                 155                 160 


Ile Arg Glu Leu Tyr Ser Leu Leu Asp Phe Leu Arg Asn Asp Phe Ser 
                165                 170                 175     


His Asn Arg Leu Asp Gly Thr Thr Phe Glu His Leu Glu Val Ser Pro 
            180                 185                 190         


Asp Ile Ser Ser Phe Ile Thr Gly Thr Tyr Ser Leu Ala Cys Gly Arg 
        195                 200                 205             


Ala Gln Ser Arg Phe Ala Asp Phe Phe Lys Pro Asp Asp Phe Val Leu 
    210                 215                 220                 


Ala Lys Asn Arg Lys Glu Gln Leu Ile Ser Val Ala Asp Gly Lys Glu 
225                 230                 235                 240 


Cys Leu Thr Val Ser Gly Leu Ala Phe Phe Ile Cys Leu Phe Leu Asp 
                245                 250                 255     


Arg Glu Gln Ala Ser Gly Met Leu Ser Arg Ile Arg Gly Phe Lys Arg 
            260                 265                 270         


Thr Asp Glu Asn Trp Ala Arg Ala Val His Glu Thr Phe Cys Asp Leu 
        275                 280                 285             


Cys Ile Arg His Pro His Asp Arg Leu Glu Ser Ser Asn Thr Lys Glu 
    290                 295                 300                 


Ala Leu Leu Leu Asp Met Leu Asn Glu Leu Asn Arg Cys Pro Arg Ile 
305                 310                 315                 320 


Leu Tyr Asp Met Leu Pro Glu Glu Glu Arg Ala Gln Phe Leu Pro Ala 
                325                 330                 335     


Leu Asp Glu Asn Ser Met Asn Asn Leu Ser Glu Asn Ser Leu Asn Glu 
            340                 345                 350         


Glu Ser Arg Leu Leu Trp Asp Gly Ser Ser Asp Trp Ala Glu Ala Leu 
        355                 360                 365             


Thr Lys Arg Ile Arg His Gln Asp Arg Phe Pro Tyr Leu Met Leu Arg 
    370                 375                 380                 


Phe Ile Glu Glu Met Asp Leu Leu Lys Gly Ile Arg Phe Arg Val Asp 
385                 390                 395                 400 


Leu Gly Glu Ile Glu Leu Asp Ser Tyr Ser Lys Lys Val Gly Arg Asn 
                405                 410                 415     


Gly Glu Tyr Asp Arg Thr Ile Thr Asp His Ala Leu Ala Phe Gly Lys 
            420                 425                 430         


Leu Ser Asp Phe Gln Asn Glu Glu Glu Val Ser Arg Met Ile Ser Gly 
        435                 440                 445             


Glu Ala Ser Tyr Pro Val Arg Phe Ser Leu Phe Ala Pro Arg Tyr Ala 
    450                 455                 460                 


Ile Tyr Asp Asn Lys Ile Gly Tyr Cys His Thr Ser Asp Pro Val Tyr 
465                 470                 475                 480 


Pro Lys Ser Lys Thr Gly Glu Lys Arg Ala Leu Ser Asn Pro Arg Ser 
                485                 490                 495     


Met Gly Phe Ile Ser Val His Asp Leu Arg Lys Leu Leu Leu Met Glu 
            500                 505                 510         


Leu Leu Cys Glu Gly Ser Phe Ser Arg Met Gln Ser Asp Phe Leu Arg 
        515                 520                 525             


Lys Ala Asn Arg Ile Leu Asp Glu Thr Ala Glu Gly Lys Leu Gln Phe 
    530                 535                 540                 


Ser Ala Leu Phe Pro Glu Met Arg His Arg Phe Ile Pro Pro Gln Asn 
545                 550                 555                 560 


Pro Lys Ser Lys Asp Arg Arg Glu Lys Ala Glu Thr Thr Leu Glu Lys 
                565                 570                 575     


Tyr Lys Gln Glu Ile Lys Gly Arg Lys Asp Lys Leu Asn Ser Gln Leu 
            580                 585                 590         


Leu Ser Ala Phe Asp Met Asn Gln Arg Gln Leu Pro Ser Arg Leu Leu 
        595                 600                 605             


Asp Glu Trp Met Asn Ile Arg Pro Ala Ser His Ser Val Lys Leu Arg 
    610                 615                 620                 


Thr Tyr Val Lys Gln Leu Asn Glu Asp Cys Arg Leu Arg Leu Arg Lys 
625                 630                 635                 640 


Phe Arg Lys Asp Gly Asp Gly Lys Ala Arg Ala Ile Pro Leu Val Gly 
                645                 650                 655     


Glu Met Ala Thr Phe Leu Ser Gln Asp Ile Val Arg Met Ile Ile Ser 
            660                 665                 670         


Glu Glu Thr Lys Lys Leu Ile Thr Ser Ala Tyr Tyr Asn Glu Met Gln 
        675                 680                 685             


Arg Ser Leu Ala Gln Tyr Ala Gly Glu Glu Asn Arg Arg Gln Phe Arg 
    690                 695                 700                 


Ala Ile Val Ala Glu Leu His Leu Leu Asp Pro Ser Ser Gly His Pro 
705                 710                 715                 720 


Phe Leu Ser Ala Thr Met Glu Thr Ala His Arg Tyr Thr Glu Asp Phe 
                725                 730                 735     


Tyr Lys Cys Tyr Leu Glu Lys Lys Arg Glu Trp Leu Ala Lys Thr Phe 
            740                 745                 750         


Tyr Arg Pro Glu Gln Asp Glu Asn Thr Lys Arg Arg Ile Ser Val Phe 
        755                 760                 765             


Phe Val Pro Asp Gly Glu Ala Arg Lys Leu Leu Pro Leu Leu Ile Arg 
    770                 775                 780                 


Arg Arg Met Lys Glu Gln Asn Asp Leu Gln Asp Trp Ile Arg Asn Lys 
785                 790                 795                 800 


Gln Ala His Pro Ile Asp Leu Pro Ser His Leu Phe Asp Ser Lys Ile 
                805                 810                 815     


Met Glu Leu Leu Lys Val Lys Asp Gly Lys Lys Lys Trp Asn Glu Ala 
            820                 825                 830         


Phe Lys Asp Trp Trp Ser Thr Lys Tyr Pro Asp Gly Met Gln Pro Phe 
        835                 840                 845             


Tyr Gly Leu Arg Arg Glu Leu Asn Ile His Gly Lys Ser Val Ser Tyr 
    850                 855                 860                 


Ile Pro Ser Asp Gly Lys Lys Phe Ala Asp Cys Tyr Thr His Leu Met 
865                 870                 875                 880 


Glu Lys Thr Val Gln Asp Lys Lys Arg Glu Leu Arg Thr Ala Gly Lys 
                885                 890                 895     


Pro Val Pro Pro Asp Leu Ala Ala Asp Ile Lys Arg Ser Phe His Arg 
            900                 905                 910         


Ala Val Asn Glu Arg Glu Phe Met Leu Arg Leu Val Gln Glu Asp Asp 
        915                 920                 925             


Arg Leu Met Leu Met Ala Ile Asn Lys Met Met Thr Asp Arg Glu Glu 
    930                 935                 940                 


Asp Ile Leu Pro Gly Leu Lys Asn Ile Asp Ser Ile Leu Asp Glu Glu 
945                 950                 955                 960 


Asn Gln Phe Ser Leu Ala Val His Ala Lys Val Leu Glu Lys Glu Gly 
                965                 970                 975     


Glu Gly Gly Asp Asn Ser Leu Ser Leu Val Pro Ala Thr Ile Glu Ile 
            980                 985                 990         


Lys Ser Lys Arg Lys Asp Trp Ser  Lys Tyr Ile Arg Tyr  Arg Tyr Asp 
        995                 1000                 1005             


Arg Arg  Val Pro Gly Leu Met  Ser His Phe Pro Glu  His Lys Ala 
    1010                 1015                 1020             


Thr Leu  Asp Glu Val Lys Thr  Leu Leu Gly Glu Tyr  Asp Arg Cys 
    1025                 1030                 1035             


Arg Ile  Lys Ile Phe Asp Trp  Ala Phe Ala Leu Glu  Gly Ala Ile 
    1040                 1045                 1050             


Met Ser  Asp Arg Asp Leu Lys  Pro Tyr Leu His Glu  Ser Ser Ser 
    1055                 1060                 1065             


Arg Glu  Gly Lys Ser Gly Glu  His Ser Thr Leu Val  Lys Met Leu 
    1070                 1075                 1080             


Val Glu  Lys Lys Gly Cys Leu  Thr Pro Asp Glu Ser  Gln Tyr Leu 
    1085                 1090                 1095             


Ile Leu  Ile Arg Asn Lys Ala  Ala His Asn Gln Phe  Pro Cys Ala 
    1100                 1105                 1110             


Ala Glu  Met Pro Leu Ile Tyr  Arg Asp Val Ser Ala  Lys Val Gly 
    1115                 1120                 1125             


Ser Ile  Glu Gly Ser Ser Ala  Lys Asp Leu Pro Glu  Gly Ser Ser 
    1130                 1135                 1140             


Leu Val  Asp Ser Leu Trp Lys  Lys Tyr Glu Met Ile  Ile Arg Lys 
    1145                 1150                 1155             


Ile Leu  Pro Ile Leu Asp His  Glu Asn Arg 
    1160                 1165             


<210>  2723
<211>  1150
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2723

Met Glu Glu Asn His Asp Ile His Val Asn Ile Val Ala Asp Lys Pro 
1               5                   10                  15      


Phe Ile Ala Gly Tyr Phe Asn Leu Ala Ser Asn His Leu Lys Glu Leu 
            20                  25                  30          


Ser Asp Ala Ile His Ala Arg Phe Pro Asn Leu Lys Asn Ala Ser Asn 
        35                  40                  45              


Phe Leu Ile Pro Thr Pro Val Asn Thr Gly Gln Asn Glu Asp Gln Cys 
    50                  55                  60                  


Val Gln Lys Lys Ile Ser Glu Met Ser Glu Ser Asp Tyr Gln Met Leu 
65                  70                  75                  80  


Leu Asp Leu Val Ser Ser Tyr Phe Arg Ala Val Ser Leu Val Lys Arg 
                85                  90                  95      


Ser Ser Phe Val Asn Gly Val Leu Asp Arg Ile Trp Leu Trp Lys Arg 
            100                 105                 110         


Ile Asn Tyr Ile Leu Ile Leu Gln Asn Ser Leu Arg Asn Tyr Tyr Thr 
        115                 120                 125             


His Tyr Cys His Pro Glu Val Ile Ile Ser Asp Ser Asp Phe Lys Asn 
    130                 135                 140                 


Leu Leu Glu Gln Met Phe Ile Ser Ser Ala Leu Asp Val Lys Glu Lys 
145                 150                 155                 160 


Arg Leu Lys Gly Glu Gln Ala Leu Arg Val Ile Lys Ser Ser Phe Glu 
                165                 170                 175     


Asp Glu Leu Lys Lys Leu Glu Ile Asp Gln Lys Lys Tyr Leu Thr Glu 
            180                 185                 190         


Lys Thr Lys Glu Asn Pro Lys Ile Ser Leu Asp Asp Asp Ser Val Arg 
        195                 200                 205             


Asn Ala Thr Leu Asn His Leu Ile Tyr Arg Met Val Lys Lys Asn Lys 
    210                 215                 220                 


Gln Thr Gly Asp Tyr Glu Ile Asn Lys Gly Tyr Gln Leu Phe Lys Leu 
225                 230                 235                 240 


Val Glu Gly Arg Thr Asp Gln Trp Arg Phe Thr Asp Asp Gly Leu Ala 
                245                 250                 255     


Phe Phe Leu Gly Leu Phe Leu Thr Lys Lys Glu Gly Leu Glu Phe Arg 
            260                 265                 270         


Ser Arg Ile Lys Gly Phe Lys Asp Asn Asn Asn Leu Ser His Asn Val 
        275                 280                 285             


Thr Gln Trp Val Phe Ser Tyr Pro Ala Phe Arg Arg Ala Asp Arg Asn 
    290                 295                 300                 


Phe Thr Thr Val Phe Ser Lys Asp Ala Phe Ile Phe Gln Met Ile Asp 
305                 310                 315                 320 


Glu Leu Asn Lys Val Pro Asp Glu Val Tyr Arg Asn Leu Pro Glu Glu 
                325                 330                 335     


Lys Gln Asp Glu Phe Leu Val Asp Ile Asn Ser Tyr Phe Lys Asp Lys 
            340                 345                 350         


Thr Asp Val Pro Gly Ser Thr Pro Glu Gln Glu Thr Val Val Asn Pro 
        355                 360                 365             


Val Ile Arg Lys Arg Tyr Glu Asp Lys Phe Glu Tyr Phe Ala Leu Arg 
    370                 375                 380                 


Tyr Leu Asp Glu Phe Ala Gly Phe Thr Arg Ile Arg Phe Gln Val Tyr 
385                 390                 395                 400 


Val Gly Asp Tyr Ile His Asp Arg Arg Glu Lys Lys Ile Gly Asn Ser 
                405                 410                 415     


Asn Leu Tyr Thr Glu Arg Glu Cys Arg Glu Lys Val Lys Thr Phe Gly 
            420                 425                 430         


Lys Leu Thr Glu Leu Gln Lys Val Lys Thr Glu Tyr Phe Glu Gly Lys 
        435                 440                 445             


Ala Val Pro Glu Ile Pro Gly Trp Arg Arg Phe Pro Asn Pro Ser Tyr 
    450                 455                 460                 


Arg Ile Glu Asn His Asn Ile Leu Leu Ala Leu Tyr Ile Lys Asn Glu 
465                 470                 475                 480 


Glu Ile Lys Asp Arg Ile Gln Lys Ala Gln Lys Ala Leu Gly Asn Ala 
                485                 490                 495     


Gly Asp Lys Glu Arg Ser Ser Arg Thr Glu Lys Pro Val Arg Gly Glu 
            500                 505                 510         


Met Leu Asn Glu Met Tyr Asn Lys Cys Pro Tyr Lys Phe Asn Ser Thr 
        515                 520                 525             


Pro Phe Ile Ala Gln Met Ser Leu Asn Glu Leu Pro Ala Leu Leu Tyr 
    530                 535                 540                 


Ala Leu Leu Ile Asp His Lys Ser Pro Glu Asp Ile Glu Asp Gln Ile 
545                 550                 555                 560 


Ile Gln Thr Tyr Gln Glu His Phe His Glu Ile Glu Lys Gly Glu Gly 
                565                 570                 575     


Lys His Leu Pro Lys Asn Leu Thr Gln Ser Asp Lys Glu Gly Ala Asp 
            580                 585                 590         


Met Gly Lys Leu Arg Arg Asp Ile Gln Gly Val Ile Asp Asp Ser Asp 
        595                 600                 605             


Glu Arg Leu Leu Ser Phe Asp Lys Leu Lys Arg Glu Lys Ser Lys Gly 
    610                 615                 620                 


Arg Asn Ser Arg Pro Leu Tyr His Val Phe Asp Ser Lys Thr Met Gly 
625                 630                 635                 640 


Glu Thr Val Ser Phe Leu Ala Lys Asp Ile Leu Arg Phe Met Pro Val 
                645                 650                 655     


Ile Tyr Arg Glu Asn Trp Lys Gly Tyr Met His Ser Glu Trp Gln Ala 
            660                 665                 670         


Leu Leu Ser His Tyr Glu Val Asn Arg Gln Ala Ala Ile Asp Leu Leu 
        675                 680                 685             


Phe Ser Cys Trp Lys Thr Gln Asn Ala Pro Glu Ser Thr Gly Met Glu 
    690                 695                 700                 


Ile Leu Asn Leu Phe Gln Lys Ser Glu Thr Phe Glu Glu Leu Tyr Glu 
705                 710                 715                 720 


Glu Tyr Leu Lys Phe Arg Lys Gln Tyr Met Arg Leu Leu Leu Val Gly 
                725                 730                 735     


Leu Gly Ser Ala Asp Ile Gln Met Phe Phe Thr Glu Lys Gly Val Trp 
            740                 745                 750         


Asn Tyr Phe His Lys Arg Leu Tyr Val Arg Asp Pro Thr Ala Thr Leu 
        755                 760                 765             


Thr Asp Arg Leu Leu Ala Arg Pro Ile Val Leu Pro Arg Gly Ile Phe 
    770                 775                 780                 


Asp Lys Lys Pro Thr Tyr Ile Lys Gly Lys Asn Pro Glu Met Asn Arg 
785                 790                 795                 800 


Glu Asp Phe Ala Asp Trp Tyr Val Tyr Pro Tyr Glu Arg Glu Cys Gly 
                805                 810                 815     


Val Gln Met Phe Tyr Gly Tyr Gly Leu Asp Thr Asp Arg Gly Phe Glu 
            820                 825                 830         


Asp Tyr Arg Ile Phe Ser Glu Ser Ile Arg Asp Asn Arg Tyr Asp Trp 
        835                 840                 845             


Ser Glu Glu His Gln Arg Glu Leu Phe Lys Lys Lys Glu Leu Ser Arg 
    850                 855                 860                 


Val Lys Asn Val Lys Arg Lys Asp Ala Phe Leu Tyr Leu Met Val Lys 
865                 870                 875                 880 


Lys Met Leu Glu Asp Glu Gly Val Pro Phe Lys Leu Ser Leu Asn Asp 
                885                 890                 895     


Phe Tyr Leu Pro Gln Glu Ala Ile Ser Lys Arg Lys Gly Val Ala Leu 
            900                 905                 910         


Gly Gln Lys Asn Arg Gln Pro Gly Asp Lys Ser Glu Asn Ile Arg Lys 
        915                 920                 925             


Glu Thr Tyr Ile Trp Asn Met Thr Leu Pro Phe Tyr Tyr Glu Arg Glu 
    930                 935                 940                 


Asp Lys Asn Glu Lys Lys His Lys Val Phe Tyr Glu Glu Lys Val Gln 
945                 950                 955                 960 


Val Lys Asp Leu Arg Thr Leu Ala Ala Arg Met Thr Asn Leu Lys Val 
                965                 970                 975     


Leu Arg Leu Phe Asp Tyr Asp Pro Ser His Leu Trp Asn Arg Lys Ser 
            980                 985                 990         


Leu Glu Ser Glu Leu Ser Asn Tyr  Glu Lys Ile Arg Arg  Glu Asn Leu 
        995                 1000                 1005             


Leu Val  Ile Ile Gln Arg Phe  Glu Arg Glu Val Leu  Leu Arg Tyr 
    1010                 1015                 1020             


Gly Trp  Lys Glu Gly Glu Val  Ala Pro Asp Asp Leu  Leu Ile Thr 
    1025                 1030                 1035             


Asp Lys  Lys Gly Lys Lys Ile  Pro Asn Phe Lys Arg  Tyr Val Phe 
    1040                 1045                 1050             


Ser Ser  Pro Leu Gly Phe Ser  Lys Glu Ala Ile Pro  Gln Leu Leu 
    1055                 1060                 1065             


Asp Asn  Ser Trp Leu Gln Leu  Lys Arg Asn Tyr Pro  Gln Ile Ala 
    1070                 1075                 1080             


Ala Phe  Ser Lys Val Ser Gln  Gly Tyr Gln Leu Ile  Gln Ile Arg 
    1085                 1090                 1095             


Asn Asn  Phe Ala His Asn Lys  Leu Pro Asp Val Ser  Phe Phe Arg 
    1100                 1105                 1110             


Glu Cys  Thr Ala Phe Leu Ala  Lys Asp Pro Ser Glu  Tyr Tyr Ser 
    1115                 1120                 1125             


Gln Tyr  Tyr Phe Arg Leu Ala  Glu Lys Ile Ile Asn  Leu Leu Glu 
    1130                 1135                 1140             


Asn Asn  Ile His Ser Asp Ala  
    1145                 1150 


<210>  2724
<211>  1081
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2724

Met Lys Lys Thr Asn Thr Tyr Phe Asp Phe Lys Asp Lys Thr Gln Lys 
1               5                   10                  15      


Tyr Phe Phe Ala Gly Leu Phe Asn Thr Ala Leu Asn Asn Phe Asp Leu 
            20                  25                  30          


Ser Leu Asp Glu Leu Ala Asn Arg Thr Gly Leu Lys Cys Asn Gly Lys 
        35                  40                  45              


Glu Leu Ile Ala Val Ala Phe Asn Asp Thr Cys Ser Gln Thr Asp Tyr 
    50                  55                  60                  


Asn Asn Arg Leu Ser Tyr Leu Ser Glu Ser Leu Ala Phe Ile Glu Leu 
65                  70                  75                  80  


Ile Lys Thr Lys Glu Arg Ser Tyr Ile Arg Leu His Leu Thr Glu Leu 
                85                  90                  95      


Tyr Asn Leu Ile Asp Asn Tyr Arg Asn Tyr Phe Thr His Leu Glu His 
            100                 105                 110         


Pro Asp Leu Ile Ile Lys Pro Leu Ile Phe Glu Leu Leu Asp Leu Phe 
        115                 120                 125             


Ile Leu Glu Ser Ala Ile Thr Val Lys Lys Glu Arg Val Lys Thr Glu 
    130                 135                 140                 


Glu Asn Lys Ser Tyr Leu Ser Lys Lys Phe Lys Leu Glu Ile Thr Ser 
145                 150                 155                 160 


Thr Phe Glu Ala Ala Asn Asn Ala Ile Asn Leu Glu Asn Lys Asn Asn 
                165                 170                 175     


Pro His Ser Lys Thr His Lys Lys Leu Ile Thr Gln Asn Asp Lys Ile 
            180                 185                 190         


Asn Phe Val Leu Ile Asn Ala Phe Tyr Asn Phe Leu Ile Asn Thr Asp 
        195                 200                 205             


Glu Ile Pro Thr Leu Lys Glu Thr Ala Arg Ser Ile Asn Lys Asp Thr 
    210                 215                 220                 


Gly Gln Ile Ser Gln Asn Gly Ile Ile Gln Leu Leu Ala Ile Phe Leu 
225                 230                 235                 240 


Asn Lys Lys Gln Leu Glu Ile Leu Phe Asp Asn Thr His Tyr Leu Lys 
                245                 250                 255     


Gly Thr Leu Lys Leu Asn His Leu Cys Thr Arg Trp Thr Tyr Ser Gln 
            260                 265                 270         


Leu Ala Tyr Arg Asn Ile Lys Lys Leu Leu Lys Ser Asp Tyr Ser Asn 
        275                 280                 285             


Asp Ser Leu Ile Leu Gln Met Leu Ser Glu Leu Thr Lys Cys Pro Lys 
    290                 295                 300                 


His Leu Tyr Pro Asn Leu Pro Asn Asn Ser Lys Gln Glu Phe Ile Glu 
305                 310                 315                 320 


Asp Leu Asn Glu Tyr Leu Lys Glu Thr Glu Tyr Phe Lys Asp Ser Ile 
                325                 330                 335     


Ala Gln Glu Thr Val Ser Asn Glu Val Ile Arg Lys Arg Tyr Glu Asp 
            340                 345                 350         


Lys Phe Pro Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe Ile Asp Phe 
        355                 360                 365             


Pro Asn Leu Arg Phe Gln Ile Asn Leu Gly Lys Phe Asn His Asn Thr 
    370                 375                 380                 


Cys Leu Lys Lys Phe Glu Asn Thr Ala Val Tyr Thr Glu Arg Gln Ile 
385                 390                 395                 400 


Leu Glu Lys Leu Thr Ile Phe Glu Lys Leu Thr Leu Ala Thr Asn Lys 
                405                 410                 415     


Lys Thr Glu Tyr Phe Leu Asn Asn Asn Leu Pro Asp Ser Glu Gly Trp 
            420                 425                 430         


Gln Glu Tyr Pro Lys Pro Ser Tyr Gln Phe Tyr Asn Asn Asn Ile Gly 
        435                 440                 445             


Phe Trp Leu Gly Ile Lys Asn Gly Ala Val Thr Asp Ala Lys Glu Lys 
    450                 455                 460                 


Arg Glu Asn Asp Lys Ser Ser Lys Phe Asp Ile Leu Lys Lys Ile Gly 
465                 470                 475                 480 


Leu Glu Cys Cys Leu Lys Lys Pro Val Ala Tyr Leu Ser Phe Asn Glu 
                485                 490                 495     


Leu Pro Ala Leu Leu Tyr Thr Val Leu Ile Glu Lys Lys Thr Ala Lys 
            500                 505                 510         


Glu Val Glu Arg Ile Phe Leu Lys Lys Ile Gly Glu Gln Thr Gly Ala 
        515                 520                 525             


Ile Asn Lys Phe Ala Asp Ile Asn Asn Phe Glu Lys Lys Ile Ile Pro 
    530                 535                 540                 


His Lys Phe Lys Glu Ile Leu Glu Asn Lys Glu Ser Asn Val Lys Trp 
545                 550                 555                 560 


Glu Lys Leu Lys Lys Asp Ile Glu Lys Glu Met Leu Ile Ser Pro Leu 
                565                 570                 575     


Asp Glu Ile Arg Ile His Tyr Lys Thr Ala Ser Lys His Pro Asn Asp 
            580                 585                 590         


Leu Ser Phe Ser Glu Lys Gly Lys Ile Ala Thr Trp Leu Ala His Asp 
        595                 600                 605             


Ile Lys Arg Phe Val Lys Ala Glu Thr Lys Lys Asp Trp Lys Gly Tyr 
    610                 615                 620                 


Gln Phe Ser Glu Phe Gln Ser Leu Leu Ala Tyr Tyr Asp Leu Lys Lys 
625                 630                 635                 640 


Met Glu Leu Leu Asn Phe Val Asn Phe Val Leu Lys Ile Asn Ile Lys 
                645                 650                 655     


Gln Asp Ile Val Phe Glu Asp Ile Asp Phe Asn Gln Lys Thr Leu Tyr 
            660                 665                 670         


Asp Phe Tyr Lys Asn Tyr Leu Ser Asn Arg Lys Lys Phe Leu Glu Gly 
        675                 680                 685             


Asn Leu Tyr Ser Ile Asp Gln Lys Asp Glu Val Pro Ala Lys Leu Trp 
    690                 695                 700                 


Arg Lys Arg Glu Leu Ser Ile Phe Thr Gly Phe Asp Asp Lys Leu Tyr 
705                 710                 715                 720 


Lys Tyr Lys Asn Phe Lys Thr Tyr Lys Glu Asn Leu Met Asn Met Pro 
                725                 730                 735     


Leu Asn Leu Pro Arg Gly Ile Phe Ser Asp Lys Gln Thr Cys Tyr Asn 
            740                 745                 750         


Lys Asn Ser Gln Asn Asn Asn Glu Leu Ala Glu Trp Phe Thr Lys Ser 
        755                 760                 765             


Asn Asn Ile Asn Asp Phe Gln Lys Phe Tyr Ser Phe Thr Arg Phe Tyr 
    770                 775                 780                 


Glu Asn Cys Gln Leu Thr Leu Asn Pro Leu Lys Gly Leu Lys Glu Gln 
785                 790                 795                 800 


Asn Asn Asn Lys Gly Val Pro Lys Glu Val Tyr Lys Asn Glu Lys Asn 
                805                 810                 815     


Ile Arg Asn Thr Met Arg Gln Asp Phe Tyr Ile Phe Glu Met Val Lys 
            820                 825                 830         


Tyr Tyr Phe Lys Ile Asn Glu Ser Leu Lys Ser Asp Leu Asn Asp Leu 
        835                 840                 845             


Lys Leu Asn Thr Leu Phe Leu Thr Lys Gln Glu Lys Glu Asn Asn Leu 
    850                 855                 860                 


Lys Val Leu Asn Gln Gln His Ser Arg Ser Lys Gly Asp Lys Ser Glu 
865                 870                 875                 880 


Asn Ile Leu Asn Glu Asn Tyr Ile Leu Ser Lys His Ile Met Met Ser 
                885                 890                 895     


Ile Leu Glu Gly Lys Ile Gln Gly Met Val Ala Leu Lys Ser Val Gly 
            900                 905                 910         


Lys Tyr Arg Phe Leu Ser Gln Asp Lys Arg Val Lys Gln Leu Val Thr 
        915                 920                 925             


Tyr Ile Pro Asp Lys Ile Trp Ser Phe Glu Glu Ile Asn Ser Glu Ile 
    930                 935                 940                 


Asp Glu Tyr Asp Lys Ile Arg Thr Phe Ser Phe Phe Lys Ile Ile His 
945                 950                 955                 960 


Glu Ile Glu Glu Lys Ile Phe Asn Lys Ala Ile Asn Asn Lys Glu Glu 
                965                 970                 975     


Ser Tyr Leu Leu Val Asp Gly His Pro Asn Phe Lys Ala Tyr Ile Ile 
            980                 985                 990         


Tyr Tyr Phe Leu Lys Thr Gln Asp  Glu Lys Asp Phe Phe  Asn Lys Leu 
        995                 1000                 1005             


Asp Val  Lys Asn Val Asn Ile  Asn Asp Ile Ala Ile  Ser Lys Phe 
    1010                 1015                 1020             


Lys Leu  Leu Phe Leu Ile Ile  Lys Ile Arg Asn Lys  Ile Cys His 
    1025                 1030                 1035             


Asn Gln  Leu Ile Ser Ser Asp  Glu Phe Ile Phe Leu  Leu Glu Phe 
    1040                 1045                 1050             


Thr Pro  Ile Glu Pro Asp Glu  Leu Tyr Met Ser Tyr  Leu Leu Lys 
    1055                 1060                 1065             


Ala Tyr  Lys Lys Ile Val Asn  Ile Ser Trp Asn Leu  Val 
    1070                 1075                 1080     


<210>  2725
<211>  1131
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2725

Met Glu Lys Thr Ile Glu Asn Gln Thr Gln Ser Lys Arg Thr Leu Asn 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Asp Glu Glu Lys Ile Thr Thr Ser Phe Leu Val Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Arg Gln Ser Leu Val Tyr Ser Asn Leu Thr 
65                  70                  75                  80  


Arg Tyr Met His Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Asp 
                85                  90                  95      


Asp Glu Arg Asp Lys Ala Glu Asn Tyr Gly Lys Asp Phe Gly Asn Leu 
            100                 105                 110         


Thr Asp Thr Leu Lys Glu Ile Phe Lys Glu Leu Asn Glu Phe Arg Asn 
        115                 120                 125             


Asp Tyr Ser His Tyr Tyr Ser Thr Glu Lys Lys Asp Lys Arg Lys Thr 
    130                 135                 140                 


Ile Val Ser Asp Lys Leu Lys Asn Phe Leu Asn Ile Asn Tyr Thr Arg 
145                 150                 155                 160 


Ala Ile Lys Tyr Thr Lys Ser Arg Phe Ile Asn Val Phe Ser Asp Asn 
                165                 170                 175     


Asn Phe Cys Leu Ala Glu Glu Ala Lys His Val Glu Asn Asp Asn Thr 
            180                 185                 190         


Ile Thr Gln Asp Gly Ile Val Phe Phe Thr Ser Met Phe Leu Asp Arg 
        195                 200                 205             


Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile Ile Gly Leu Lys Gly Thr 
    210                 215                 220                 


Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Thr Leu Met Ala Phe Cys 
225                 230                 235                 240 


Val Asn Leu Pro His Asp Lys Phe Val Ser Glu Asn Ser Glu Gln Gln 
                245                 250                 255     


Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu 
            260                 265                 270         


Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln His Phe Leu Pro Lys Leu 
        275                 280                 285             


Asp Asp Glu Gln Ile Asp Asn Val Leu Glu Asn Ser Val Pro Tyr Thr 
    290                 295                 300                 


Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn Ile Thr Lys Lys Val Arg 
305                 310                 315                 320 


Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu Lys Phe Ile Asp Gln Lys 
                325                 330                 335     


Lys Leu Phe Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val 
            340                 345                 350         


Leu Asp Glu Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Lys Arg Thr 
        355                 360                 365             


Val Thr Glu Asn Thr Lys Ala Phe Gly Met Leu Gln Asp Leu Asn Asp 
    370                 375                 380                 


Glu Glu Asn Val Leu Asn Lys Ile Asn Thr Gly Glu Ser Lys Ala Lys 
385                 390                 395                 400 


Phe Asp Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Thr Lys Asn 
            420                 425                 430         


Thr Asp Asn Lys Ile Lys Ser Asn Leu Leu Gln Pro Leu Pro Glu Ala 
        435                 440                 445             


Phe Leu Ser Ile Asn Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
    450                 455                 460                 


Glu Gln Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn 
465                 470                 475                 480 


Asn Ser Lys Ile Leu Asn Lys Glu Phe Ile Lys Ala Ile Lys Leu Lys 
                485                 490                 495     


Leu Asn Asp Leu Asp Val Phe Tyr Lys Arg Ser Gln Gly Arg Lys Gln 
            500                 505                 510         


Lys His Ala Tyr Leu Thr Lys Asp Lys Lys Tyr Asp Asn Glu Lys Ile 
        515                 520                 525             


Asn Glu Leu Lys Asn Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu 
    530                 535                 540                 


Tyr Asn Leu Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp 
545                 550                 555                 560 


Leu Asn Ile Ala Asp Val Gln Ala Lys Asn Ala Ile Ser Asp Arg Ile 
                565                 570                 575     


Lys Leu Met Lys Arg Asp Cys Ile Asn Arg Leu Lys Ser Met Lys Lys 
            580                 585                 590         


Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp 
        595                 600                 605             


Ile Val Asp Met Ile Ile Asp Glu Glu Lys Lys Lys Lys Ile Thr Ser 
    610                 615                 620                 


Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Lys 
625                 630                 635                 640 


Glu Lys Lys Glu Leu Phe Ile Leu Ile Cys Asn Asn Glu Leu Lys Leu 
                645                 650                 655     


Asn Asp Asp Asp Gly His Pro Phe Phe Lys Asn Ile Asn Phe Ser Asn 
            660                 665                 670         


Tyr Lys Tyr Thr Ser Glu Ile Tyr Gln Lys Tyr Leu Glu Glu Lys Gly 
        675                 680                 685             


His Lys Met Val Lys Glu Tyr Asn Pro Arg Lys Glu Asn Tyr Val Glu 
    690                 695                 700                 


Lys Asp Lys Ser Trp Leu Glu Ile Asn Phe Tyr Lys Lys Glu Trp Asn 
705                 710                 715                 720 


Glu Asn Ala Lys Lys Asp Leu Thr Val Val Lys Leu Pro Asp Asp Lys 
                725                 730                 735     


Ser Lys Ile Pro Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser 
            740                 745                 750         


Phe Glu Asn Trp Phe Lys Tyr Val Thr Asn Gly Lys Glu Thr Thr Asp 
        755                 760                 765             


Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp Glu Thr Leu 
    770                 775                 780                 


Lys Glu Leu Leu Lys Lys Glu Leu Ser Lys Asn Asn Ile Glu Phe Lys 
785                 790                 795                 800 


Glu Glu Asp Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Asp Lys Cys 
                805                 810                 815     


Arg Asn Asp Lys Thr Gln Lys Phe Tyr Ser Ala Glu Arg Glu Tyr Thr 
            820                 825                 830         


Phe Glu Glu Glu Lys Leu Asn Phe His Ile Asn Thr Lys Ser Lys Phe 
        835                 840                 845             


Glu Glu Tyr Ile Asn Pro Glu Phe Ala Glu Lys Val Phe Arg Leu Lys 
    850                 855                 860                 


Asn Gln Asn Arg Glu Lys Asp Asn Ile Ser Gly Arg Arg Leu Pro Pro 
865                 870                 875                 880 


Leu Lys Met Lys Glu Val Thr Lys Asn Met Val Lys Arg Ile Gly Asn 
                885                 890                 895     


Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Leu Met Leu 
            900                 905                 910         


Leu Met Phe Glu Lys Leu Val Asp Asn Asn Leu Lys Leu Lys Leu Glu 
        915                 920                 925             


Asn Val Asp Lys Leu Leu Asn Glu Ser Ile Glu Ile Asn Gln Ser Ile 
    930                 935                 940                 


Ser Gly Lys Leu Ser Phe Asp Asp Ser Gly Asp Asn Glu Asn Lys Lys 
945                 950                 955                 960 


Asp Arg Ala Ile Ile Cys Arg Asn Ile Thr Glu Thr Arg Lys Arg Lys 
                965                 970                 975     


Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Glu Glu Glu  Asn Ile Pro Ile Glu  Lys Ile Lys 
        995                 1000                 1005             


Ile Glu  Leu Asp Thr Tyr Ser  Lys Ala Lys Asp Val  Val Phe Asp 
    1010                 1015                 1020             


Leu Ile  Phe Asp Leu Glu Arg  Ala Ile Ile Asn Lys  Asp Glu Asn 
    1025                 1030                 1035             


Arg Ile  Lys Glu Leu Asn Lys  Asp Lys Asn Gly Val  Ile Gln Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Phe Trp Leu  Leu Glu Lys 
    1055                 1060                 1065             


Asn Leu  Ile Thr Glu Gln Glu  Phe Thr Phe Met Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Ile  Phe Ser His Asn Gln  Phe Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Leu Phe  Ile Lys Asn Trp Asn  Glu Asn Glu Phe Ala  Lys Gln Ile 
    1100                 1105                 1110             


Leu Asn  Val Tyr Asn Gln Lys  Asn Asn Asn Leu Ile  Lys Ser Ile 
    1115                 1120                 1125             


Lys Asp  Ile 
    1130     


<210>  2726
<211>  1000
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2726

Met Gly Ala Ile Lys Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Gly Tyr 
                325                 330                 335     


Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr Ile Asn Phe 
            340                 345                 350         


Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser Ala Lys Lys 
        355                 360                 365             


Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser Thr Asp Ser 
    370                 375                 380                 


Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln Ser Thr Pro 
385                 390                 395                 400 


His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val Leu Pro Glu 
                405                 410                 415     


Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala Lys Met Pro 
            420                 425                 430         


Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala Met Leu Phe 
        435                 440                 445             


Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His Cys Pro Leu 
    450                 455                 460                 


Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser Thr Lys Gln 
465                 470                 475                 480 


Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg Val Met Lys 
                485                 490                 495     


Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu Arg Ile Lys 
            500                 505                 510         


Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile Leu Lys Ala 
        515                 520                 525             


Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp Leu Gln Pro 
    530                 535                 540                 


Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn Phe Gln Ala 
545                 550                 555                 560 


Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn Asp Leu Thr 
                565                 570                 575     


Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn Pro His Pro 
            580                 585                 590         


Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile Glu Phe Tyr 
        595                 600                 605             


Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg Ile Gln Lys 
    610                 615                 620                 


Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro Leu Arg Asp 
625                 630                 635                 640 


Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu Ala Ile Phe 
                645                 650                 655     


Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys Leu Lys Lys 
            660                 665                 670         


Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu Lys Ser Pro 
        675                 680                 685             


Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg Thr Tyr Phe 
    690                 695                 700                 


Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn Tyr Arg Leu 
705                 710                 715                 720 


Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser Tyr Leu Ser 
                725                 730                 735     


Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro Ser Lys Ile 
            740                 745                 750         


Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp Arg Leu Tyr 
        755                 760                 765             


Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile Ile Arg Leu 
    770                 775                 780                 


Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys Glu Tyr Leu 
785                 790                 795                 800 


Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu Glu Asn Val 
                805                 810                 815     


Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp Leu Asn Pro 
            820                 825                 830         


Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr Gly Lys Leu 
        835                 840                 845             


Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn Lys Val Leu 
    850                 855                 860                 


Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val Lys Ile Gln 
865                 870                 875                 880 


Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu Glu Ala Gln 
                885                 890                 895     


Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala Met Val Ser 
            900                 905                 910         


Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr Tyr Asp Phe 
        915                 920                 925             


Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln Lys Ile Asp 
    930                 935                 940                 


Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His Asp Lys Tyr 
945                 950                 955                 960 


Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val Tyr Ala Lys 
                965                 970                 975     


Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile Lys Leu Glu 
            980                 985                 990         


Asp Leu Ser Asn Asp Ser Ser Ala  
        995                 1000 


<210>  2727
<211>  1131
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2727

Met Glu Lys Thr Ile Glu Asn Gln Thr Gln Ser Lys Arg Thr Leu Asn 
1               5                   10                  15      


Asn Thr Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Asp Glu Glu Lys Ile Thr Thr Ser Phe Leu Val Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Arg Gln Ser Leu Val Tyr Ser Asn Leu Thr 
65                  70                  75                  80  


Arg Tyr Met His Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Asp 
                85                  90                  95      


Asp Glu Arg Asp Lys Ala Glu Asn Tyr Gly Lys Asp Phe Gly Asn Leu 
            100                 105                 110         


Thr Asp Thr Leu Lys Glu Ile Phe Lys Glu Leu Asn Glu Phe Arg Asn 
        115                 120                 125             


Asp Tyr Ser His Tyr Tyr Ser Thr Glu Lys Lys Asp Lys Arg Lys Thr 
    130                 135                 140                 


Ile Val Ser Asp Lys Leu Lys Asn Phe Leu Asn Ile Asn Tyr Thr Arg 
145                 150                 155                 160 


Ala Ile Lys Tyr Thr Lys Ser Arg Phe Ile Asn Val Phe Ser Asp Asn 
                165                 170                 175     


Asn Phe Cys Leu Ala Glu Glu Ala Lys His Val Glu Asn Asp Asn Thr 
            180                 185                 190         


Ile Thr Gln Asp Gly Ile Val Phe Phe Thr Ser Met Phe Leu Asp Arg 
        195                 200                 205             


Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile Ile Gly Leu Lys Gly Thr 
    210                 215                 220                 


Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Thr Leu Met Ala Phe Cys 
225                 230                 235                 240 


Val Asn Leu Pro His Asp Lys Phe Val Ser Glu Asn Ser Glu Gln Gln 
                245                 250                 255     


Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu 
            260                 265                 270         


Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln His Phe Leu Pro Lys Leu 
        275                 280                 285             


Asp Asp Glu Gln Ile Asp Asn Val Leu Glu Asn Ser Val Pro Tyr Thr 
    290                 295                 300                 


Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn Ile Thr Lys Lys Val Arg 
305                 310                 315                 320 


Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu Lys Phe Ile Asp Gln Lys 
                325                 330                 335     


Lys Leu Phe Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val 
            340                 345                 350         


Leu Asp Glu Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Lys Arg Thr 
        355                 360                 365             


Val Thr Glu Asn Thr Lys Ala Phe Gly Met Leu Gln Asp Leu Asn Asp 
    370                 375                 380                 


Glu Glu Asn Val Leu Asn Lys Ile Asn Thr Gly Glu Ser Lys Ala Lys 
385                 390                 395                 400 


Phe Asp Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Thr Lys Asn 
            420                 425                 430         


Thr Asp Asn Lys Ile Lys Ser Asn Leu Leu Gln Pro Leu Pro Glu Ala 
        435                 440                 445             


Phe Leu Ser Ile Asn Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
    450                 455                 460                 


Glu Gln Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn 
465                 470                 475                 480 


Asn Ser Lys Ile Leu Asn Lys Glu Phe Ile Lys Ala Ile Lys Leu Lys 
                485                 490                 495     


Leu Asn Asp Leu Asp Val Phe Tyr Lys Arg Ser Gln Gly Arg Lys Gln 
            500                 505                 510         


Lys His Ala Tyr Leu Thr Lys Asp Lys Lys Tyr Asp Asn Glu Lys Ile 
        515                 520                 525             


Asn Glu Leu Lys Asn Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu 
    530                 535                 540                 


Tyr Asn Leu Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp 
545                 550                 555                 560 


Leu Asn Ile Ala Asp Val Gln Ala Lys Asn Ala Ile Ser Asp Arg Ile 
                565                 570                 575     


Lys Leu Met Lys Arg Asp Cys Ile Asn Arg Leu Lys Ser Met Lys Lys 
            580                 585                 590         


Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp 
        595                 600                 605             


Ile Val Asp Met Ile Ile Asp Glu Glu Lys Lys Lys Lys Ile Thr Ser 
    610                 615                 620                 


Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Lys 
625                 630                 635                 640 


Glu Lys Lys Glu Leu Phe Ile Leu Ile Cys Asn Asn Glu Leu Lys Leu 
                645                 650                 655     


Asn Asp Asp Asp Gly His Pro Phe Phe Lys Asn Ile Asn Phe Ser Asn 
            660                 665                 670         


Tyr Lys Tyr Thr Ser Glu Ile Tyr Gln Lys Tyr Leu Glu Glu Lys Gly 
        675                 680                 685             


His Lys Met Val Lys Glu Tyr Asn Pro Arg Lys Glu Asn Tyr Val Glu 
    690                 695                 700                 


Lys Asp Lys Ser Trp Leu Glu Ile Asn Phe Tyr Lys Lys Glu Trp Asn 
705                 710                 715                 720 


Glu Asn Ala Lys Lys Asp Leu Thr Val Val Lys Leu Pro Asp Asp Lys 
                725                 730                 735     


Ser Lys Ile Pro Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser 
            740                 745                 750         


Phe Glu Asn Trp Phe Lys Tyr Val Thr Asn Gly Lys Glu Thr Thr Asp 
        755                 760                 765             


Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp Glu Thr Leu 
    770                 775                 780                 


Lys Glu Leu Leu Lys Lys Glu Leu Ser Lys Asn Asn Ile Glu Phe Lys 
785                 790                 795                 800 


Glu Glu Asp Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Asp Lys Cys 
                805                 810                 815     


Arg Asn Asp Lys Thr Gln Lys Phe Tyr Ser Ala Glu Arg Glu Tyr Thr 
            820                 825                 830         


Phe Glu Glu Glu Lys Leu Asn Phe His Ile Asn Thr Lys Ser Lys Phe 
        835                 840                 845             


Glu Glu Tyr Ile Asn Pro Glu Phe Ala Glu Lys Val Phe Arg Leu Lys 
    850                 855                 860                 


Asn Gln Asn Arg Glu Lys Asp Asn Ile Ser Gly Arg Arg Leu Pro Pro 
865                 870                 875                 880 


Leu Lys Met Lys Glu Val Thr Lys Asn Met Val Lys Arg Ile Gly Asn 
                885                 890                 895     


Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Leu Met Leu 
            900                 905                 910         


Leu Met Phe Glu Lys Leu Val Asp Asn Asn Leu Lys Leu Lys Leu Glu 
        915                 920                 925             


Asn Val Asp Lys Leu Leu Asn Glu Ser Ile Glu Ile Asn Gln Ser Ile 
    930                 935                 940                 


Ser Gly Lys Leu Ser Phe Asp Asp Ser Gly Asp Asn Glu Asn Lys Lys 
945                 950                 955                 960 


Asp Arg Ala Ile Ile Cys Arg Asn Ile Thr Glu Thr Arg Lys Arg Lys 
                965                 970                 975     


Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Glu Glu Glu  Asn Ile Pro Ile Glu  Lys Ile Lys 
        995                 1000                 1005             


Ile Glu  Leu Asp Thr Tyr Ser  Lys Ala Lys Asp Val  Val Phe Asp 
    1010                 1015                 1020             


Leu Ile  Phe Asp Leu Glu Arg  Ala Ile Ile Asn Lys  Asp Glu Asn 
    1025                 1030                 1035             


Arg Ile  Lys Glu Leu Asn Lys  Asp Lys Asn Gly Val  Ile Gln Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Phe Trp Leu  Leu Glu Lys 
    1055                 1060                 1065             


Asn Leu  Ile Thr Glu Gln Glu  Phe Thr Phe Met Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Thr  Phe Ser His Asn Gln  Phe Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Leu Phe  Ile Lys Asn Trp Asn  Glu Asn Glu Phe Ala  Lys Gln Ile 
    1100                 1105                 1110             


Leu Asn  Val Tyr Asn Gln Lys  Asn Asn Asn Leu Ile  Lys Ser Ile 
    1115                 1120                 1125             


Lys Asp  Ile 
    1130     


<210>  2728
<211>  1025
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2728

Met Lys His Phe Pro Phe Leu Glu Ala Ala Ala Tyr Glu Met Thr Asn 
1               5                   10                  15      


Ser Lys Ser Pro Asn Asn Lys Glu Gln Arg Glu Lys Glu Gln Ser Glu 
            20                  25                  30          


Ala Leu Ser Leu Asn Asn Leu Lys Asn Val Leu Phe Ile Phe Leu Glu 
        35                  40                  45              


Lys Leu Gln Val Leu Arg Asn Tyr Tyr Ser His Tyr Lys Tyr Ser Glu 
    50                  55                  60                  


Glu Ser Pro Lys Pro Ile Phe Glu Thr Ser Leu Leu Lys Asn Met Tyr 
65                  70                  75                  80  


Lys Val Phe Asp Ala Asn Val Arg Leu Val Lys Arg Asp Tyr Met His 
                85                  90                  95      


His Glu Asn Ile Asp Met Gln Arg Asp Phe Thr His Leu Asn Arg Lys 
            100                 105                 110         


Lys Gln Val Gly Arg Thr Lys Asn Ile Ile Asp Ser Pro Asn Phe His 
        115                 120                 125             


Tyr His Phe Ala Asp Lys Glu Gly Asn Met Thr Ile Ala Gly Leu Leu 
    130                 135                 140                 


Phe Phe Val Ser Leu Phe Leu Asp Lys Lys Asp Ala Ile Trp Met Gln 
145                 150                 155                 160 


Lys Lys Leu Lys Gly Phe Lys Asp Gly Arg Asn Leu Arg Glu Gln Met 
                165                 170                 175     


Thr Asn Glu Val Phe Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys 
            180                 185                 190         


Leu Glu Asn Val Gln Thr Lys Asp Trp Met Gln Leu Asp Met Leu Asn 
        195                 200                 205             


Glu Leu Val Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Arg Glu Lys 
    210                 215                 220                 


Asp Arg Glu Ser Phe Lys Val Pro Phe Asp Ile Phe Ser Asp Asp Tyr 
225                 230                 235                 240 


Asp Ala Glu Glu Glu Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp 
                245                 250                 255     


Arg Phe Pro Tyr Phe Val Leu Arg Phe Phe Asp Leu Asn Glu Ile Phe 
            260                 265                 270         


Glu Gln Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe Ser Ile 
        275                 280                 285             


Tyr Asn Lys Leu Ile Gly Asp Glu Asp Glu Val Arg His Leu Thr His 
    290                 295                 300                 


His Leu Tyr Gly Phe Ala Arg Ile Gln Asp Phe Ala Pro Gln Asn Gln 
305                 310                 315                 320 


Pro Glu Glu Trp Arg Lys Leu Val Lys Asp Leu Asp His Phe Glu Thr 
                325                 330                 335     


Ser Gln Lys Pro Tyr Ile Ser Lys Thr Ala Pro His Tyr His Leu Glu 
            340                 345                 350         


Asn Glu Lys Ile Gly Ile Lys Phe Cys Ser Thr His Asn Asn Leu Phe 
        355                 360                 365             


Pro Ser Leu Lys Arg Glu Lys Thr Cys Asn Gly Arg Ser Lys Phe Asn 
    370                 375                 380                 


Leu Gly Thr Gln Phe Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu 
385                 390                 395                 400 


Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Thr Lys Asp His Pro Lys 
                405                 410                 415     


Gly Glu Gly Ile Asn Lys Ile Glu Lys Ile Ile Arg Thr Glu Ile Ser 
            420                 425                 430         


Asn Ile Tyr Ala Ile Tyr Asp Ala Phe Ala Asn Gly Glu Ile Asn Ser 
        435                 440                 445             


Ile Ala Asp Leu Thr Cys Arg Leu Gln Lys Thr Asn Ile Leu Gln Gly 
    450                 455                 460                 


His Leu Pro Lys Gln Met Ile Ser Ile Leu Gly Gly Arg Gln Lys Asp 
465                 470                 475                 480 


Met Glu Lys Glu Ala Glu Arg Lys Ile Gly Glu Met Ile Asp Asp Thr 
                485                 490                 495     


Gln Arg Arg Leu Asp Leu Leu Cys Lys Gln Thr Asn Gln Lys Ile Arg 
            500                 505                 510         


Ile Gly Lys Arg Asn Ala Gly Leu Leu Lys Ser Gly Lys Ile Ala Asp 
        515                 520                 525             


Trp Leu Val Ser Asp Met Met Arg Phe Gln Pro Val Gln Lys Asp Thr 
    530                 535                 540                 


Asn Asn Ala Pro Ile Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg 
545                 550                 555                 560 


Met Leu Gln His Ala Leu Ala Leu Phe Gly Ser Glu Ser Ser Arg Leu 
                565                 570                 575     


Lys Ala Tyr Phe Arg Gln Met Asn Leu Val Gly Asn Ala Asn Pro His 
            580                 585                 590         


Pro Phe Leu Ala Glu Thr Gln Trp Glu His Gln Thr Asn Ile Leu Ser 
        595                 600                 605             


Phe Tyr Arg Asn Tyr Leu Glu Ala Arg Lys Lys Tyr Leu Lys Gly Leu 
    610                 615                 620                 


Lys Pro Gln Asn Trp Lys Gln Tyr Gln His Phe Leu Ile Leu Lys Val 
625                 630                 635                 640 


Gln Lys Thr Asn Arg Asn Thr Leu Val Thr Gly Trp Lys Asn Ser Phe 
                645                 650                 655     


Asn Leu Pro Arg Gly Ile Phe Thr Gln Pro Ile Arg Glu Trp Phe Glu 
            660                 665                 670         


Lys His Asn Asn Ser Lys Arg Ile Tyr Asp Gln Ile Leu Ser Phe Asp 
        675                 680                 685             


Arg Val Gly Phe Val Ala Lys Ala Ile Pro Leu Tyr Phe Ala Glu Glu 
    690                 695                 700                 


Tyr Lys Asp Asn Val Gln Pro Phe Tyr Asp Tyr Pro Phe Asn Ile Gly 
705                 710                 715                 720 


Asn Lys Leu Lys Pro Gln Lys Gly Gln Phe Leu Asp Lys Lys Glu Arg 
                725                 730                 735     


Val Glu Leu Trp Gln Lys Asn Lys Glu Leu Phe Lys Asn Tyr Pro Ser 
            740                 745                 750         


Glu Lys Lys Lys Thr Asp Leu Ala Tyr Leu Asp Phe Leu Ser Trp Lys 
        755                 760                 765             


Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys Asn Gln Asp Ile Val Thr 
    770                 775                 780                 


Trp Leu Met Phe Lys Glu Leu Phe Asn Met Ala Thr Val Glu Gly Leu 
785                 790                 795                 800 


Lys Ile Gly Glu Ile His Leu Arg Asp Ile Asp Thr Asn Thr Ala Lys 
                805                 810                 815     


Ala Glu Ser Asn Asn Ile Leu Asn Arg Ile Met Pro Met Lys Leu Pro 
            820                 825                 830         


Val Lys Thr Tyr Glu Ile Asn Asn Lys Gly Lys Met Glu Met Glu Lys 
        835                 840                 845             


Pro Leu Ala Thr Phe Tyr Ile Glu Glu Thr Glu Thr Lys Val Leu Lys 
    850                 855                 860                 


Gln Gly Asn Phe Lys Ala Leu Val Lys Asp Arg Arg Leu Asn Gly Leu 
865                 870                 875                 880 


Phe Ser Phe Ala Glu Thr Thr Asp Leu Asn Leu Glu Glu His Pro Ile 
                885                 890                 895     


Ser Lys Leu Ser Val Asp His Glu Leu Ile Lys Tyr Gln Thr Thr Arg 
            900                 905                 910         


Val Arg Ile Phe Glu Met Val Leu Arg Leu Glu Lys Lys Leu Ile Asn 
        915                 920                 925             


Lys Tyr Pro Thr Leu Pro Thr Tyr Ser Phe Lys Asn Met Leu Glu Ser 
    930                 935                 940                 


Trp Leu Glu Asp Lys Thr Asn Ser Ala Glu Leu Asn Asn Tyr Val Asp 
945                 950                 955                 960 


Cys Leu Ile Ala Val Arg Asn Ala Phe Ala His Asn Gln Tyr Pro Met 
                965                 970                 975     


Tyr Asn Pro Lys Leu Phe Ala Glu Val Lys Lys Phe Ser Leu Phe Pro 
            980                 985                 990         


Ser Ser Asn Thr Lys Lys Thr Glu  Leu Asn Ile Ala Pro  Gln Leu Leu 
        995                 1000                 1005             


Glu Ile  Val Gly Lys Ala Ile  Lys Glu Ile Glu Lys  Ser Glu Asn 
    1010                 1015                 1020             


Lys Asn  
    1025 


<210>  2729
<211>  1124
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2729

Met Ser Val Ala Thr Gln Glu His Ile Asn Ser Leu Lys Phe Ile Glu 
1               5                   10                  15      


Thr Ala Glu Arg Asn Lys Phe Tyr Tyr Gly Met Tyr Leu Ser Val Ala 
            20                  25                  30          


Gln Arg Asn Ala Tyr Leu Ser Leu Lys Ser Ile Tyr Glu Lys Leu Glu 
        35                  40                  45              


Ile Lys Glu Glu Lys Arg Gln Ile Ser Glu Asp Asn Pro His Lys Ala 
    50                  55                  60                  


Asp Ile Phe Cys Glu Leu Ile Pro Pro Asp Glu Asn Thr Ser Asn Cys 
65                  70                  75                  80  


Asp Ala His Pro Tyr Val Gln Leu Arg Pro Ser Glu Ile Glu Ser Arg 
                85                  90                  95      


Lys Arg Leu Leu Ala Lys His Phe Pro Ala Phe Arg Lys Leu Ser Glu 
            100                 105                 110         


Thr Ile Asn Glu Lys Gly Lys Val Thr Gly Phe Asp Val Val Arg Leu 
        115                 120                 125             


Ala Lys Leu Leu Lys Cys Ser Leu Glu Tyr Leu Asn Lys Leu Arg Asn 
    130                 135                 140                 


Tyr Phe Ser His Tyr Tyr His Lys Pro Ile Ser Gly Asp Thr Ile Pro 
145                 150                 155                 160 


Asp Ile Tyr Leu Pro Glu Leu Leu Glu Ala Ala Val Glu Lys Val Gln 
                165                 170                 175     


Lys Arg Phe Pro Asp Ile Asn Thr Glu His Gly Glu Tyr Leu Lys Thr 
            180                 185                 190         


Leu Pro Leu Thr Val Asp Asn Gln Tyr Asn Tyr Asn Gly Gly Ile Leu 
        195                 200                 205             


Phe Met Cys Met Phe Leu Asp Arg Arg Asn Ala Phe Ala Phe Leu Lys 
    210                 215                 220                 


Thr Thr Tyr Met Arg Gly Phe Lys Asp Ser Arg Thr Pro Asp Met Arg 
225                 230                 235                 240 


Val Lys Pro Glu Ala Phe Ile Tyr Phe Cys Ala Arg Pro Pro Gln Pro 
                245                 250                 255     


Lys Leu Gly Ser Ser Asp Leu Pro Leu Asp Met Leu Thr Glu Ile Ser 
            260                 265                 270         


Arg Cys Pro Asn Glu Ile Phe Gln Leu Leu Ser Thr Asn Asp Lys Lys 
        275                 280                 285             


Lys Phe Glu Ala Asp Ile Asp Asp Asp Ala Lys Pro Thr Glu Leu Asp 
    290                 295                 300                 


Glu Phe Leu Lys Asp Glu Leu Pro Pro Arg Thr Ala Asn Met Lys Arg 
305                 310                 315                 320 


Lys Ala Glu Asn Ser His Phe Pro Arg Tyr Ala Met Arg Tyr Phe Asp 
                325                 330                 335     


Glu Gln Lys Lys Phe Gly Arg Leu Arg Phe Gln Leu Leu Cys Ala Lys 
            340                 345                 350         


Phe Asn Cys Ala Asp Tyr Lys Ser Thr Ile Leu Glu Gln Glu Arg Asn 
        355                 360                 365             


Arg Lys Ile Glu Asp Thr Leu Thr Val Phe Thr Arg Leu Asn Glu Ile 
    370                 375                 380                 


Thr Glu Asp Glu Ile Glu Ser Ser Trp Lys Thr Glu Asp Thr Asp Asn 
385                 390                 395                 400 


Glu His Ile Gly Ile Lys Gln Tyr Ser Pro Lys Tyr Asn Ile Val Gly 
                405                 410                 415     


Asn Arg Ile Ala Ile Lys Ile Leu Pro Glu Glu Ile Thr Asn Asp Ile 
            420                 425                 430         


Glu Thr Thr Ser Ile Val His Pro Lys Ser Thr His Thr Asp Lys Pro 
        435                 440                 445             


Arg His Lys Val Asn His Pro Leu Pro Thr Ala Ile Leu Ser Val His 
    450                 455                 460                 


Glu Leu Gln Asn Leu Phe Leu Phe Arg His Leu His Asn Glu Glu Asn 
465                 470                 475                 480 


Ala Thr Glu Asn Phe Ile Glu Thr Tyr Ile Lys Arg Phe Arg Asp Phe 
                485                 490                 495     


Cys Gln Glu Val Asn Glu Gly Asp Phe Leu Pro Val Ser Asn Phe Leu 
            500                 505                 510         


Asp Cys Leu Val Ser Lys Lys Ser Lys Asp Gln Asp Lys Ala Ala Arg 
        515                 520                 525             


Lys Thr Ala Leu Gln Ala Lys Leu Lys Ala Lys Lys Leu His Ile Asn 
    530                 535                 540                 


Asp Leu Pro Asp Gln Met Arg Asp Tyr Leu Met Gly Tyr Thr Gln Asp 
545                 550                 555                 560 


Asn His Ser Asn Gln Leu Lys Ala Lys Leu Lys Ala Lys Ile Ile Glu 
                565                 570                 575     


Thr Glu Ala Leu Leu Ser Asn Ala Lys Arg Gly Lys Asp Ala Gln Gly 
            580                 585                 590         


Arg Asp Leu Lys Asp Gly Arg Met Ala Thr Tyr Ile Ala Arg Asp Leu 
        595                 600                 605             


Ile Phe Phe Lys Lys Lys Asn Asn Ser Gly Gly Lys Ala Asn Asn Glu 
    610                 615                 620                 


Gln Tyr Asn Glu Leu Gln Lys Ala Ile Ala Leu Phe Pro Ser His Lys 
625                 630                 635                 640 


Gly Lys Leu Gly Gln Tyr Phe Lys Asp Leu Asn Leu Leu Asp Ser Ser 
                645                 650                 655     


Thr Gly His Gln Phe Leu His Glu Ile Pro Trp Ser Tyr Cys Val Asp 
            660                 665                 670         


Thr Ala Asp Phe Tyr Thr Asp Tyr Leu Glu Gly Lys Lys Thr Trp Leu 
        675                 680                 685             


Glu Ser Cys Arg Arg Lys Leu Ser Ser Lys Gln Ala Asp Ile Gln Gln 
    690                 695                 700                 


Phe Phe Lys Leu Lys Lys Thr Asp Ser Lys Asn Leu Asn Tyr Arg Phe 
705                 710                 715                 720 


Thr Val Asn Gln Asn Ser Met Thr Glu Glu Pro Ala Pro Ile Tyr Leu 
                725                 730                 735     


Pro Arg Gly Leu Phe Asn Gly Ala Ile Arg Lys Ala Met Lys Asn Gln 
            740                 745                 750         


Gly Phe Asp Val Asn Lys Glu Thr Ser Ile Thr Lys Cys Phe Glu Leu 
        755                 760                 765             


Ile Ser Lys Gln Asp Thr Gln Thr Phe Tyr Thr His Pro Arg Thr Tyr 
    770                 775                 780                 


Tyr Asp Gly Ile Val Ile Thr Gly Lys Asp Asp Met Lys Ala Val Lys 
785                 790                 795                 800 


Ala Asp Ile Gln Gln Lys Thr Glu Gln Thr Lys Thr Lys Leu Lys Arg 
                805                 810                 815     


Ile Lys Asn Lys Lys Ser Glu Asp Ala Lys Lys Leu Gln Tyr Lys Ile 
            820                 825                 830         


Asn Asp Leu Asn Lys Leu Pro Lys Glu Ile Tyr Arg Asn Glu Leu Lys 
        835                 840                 845             


Ile Arg Phe Ile Gln Ala Asn Asp Arg Ala Ala Phe Met Met Ile Gln 
    850                 855                 860                 


Glu Met Leu Glu Ala Lys Ile Lys Ala Asp Gln Val Gln Leu Arg Ala 
865                 870                 875                 880 


Pro Asp Ser Asp Thr Ser Lys Trp Gln Leu Arg Lys Val Gly Phe Asp 
                885                 890                 895     


Val Lys Asp Asn Ile Leu Asp Gln Lys His Leu Met Gln His Thr Tyr 
            900                 905                 910         


Lys Leu Glu Tyr Lys Asp Lys Asn Asn Ser Asn Asn Asp Glu Tyr Phe 
        915                 920                 925             


Gly Ser Arg Thr Ile Gln Ala Leu Leu Pro Phe Lys Gln Tyr Gly Lys 
    930                 935                 940                 


Phe Arg Arg Phe Leu Lys Asp Lys Arg Leu Trp Ser Thr Arg Thr Lys 
945                 950                 955                 960 


Asp Gly Leu Arg Leu Pro Gln Gly Leu Leu Ser Tyr Tyr Ser Glu Gly 
                965                 970                 975     


Asp Val Ile Glu Leu Glu Thr Ile Arg Arg Glu Phe Val Asn Phe Asp 
            980                 985                 990         


Thr Lys Cys Tyr Glu Glu Thr Leu  Leu His Ile Tyr Asp  Phe Glu Ser 
        995                 1000                 1005             


Ile Leu  His Gln Glu Phe Gln  Thr Glu Phe Asn Glu  Lys Ile Arg 
    1010                 1015                 1020             


Asn Lys  Lys Ser Leu Arg His  Gly Asp Gln Leu Ala  Leu Val Gln 
    1025                 1030                 1035             


Thr Lys  Ile Leu Asn Asn Thr  Ser Val Leu Thr Asn  Pro Asp Lys 
    1040                 1045                 1050             


Asp Asp  Thr Ala Ile Met Arg  Asn Lys Ile Phe His  His Gln Ile 
    1055                 1060                 1065             


Pro Asn  Asn Asp Trp Leu Thr  Gln Lys Val Ile Val  Tyr Lys Gly 
    1070                 1075                 1080             


Leu Glu  Ala Asn Arg Lys Lys  Gln Asp Glu Asp Asn  Pro Phe Ile 
    1085                 1090                 1095             


Thr Gln  Gln Ile Phe Val Gly  Ile Gln Thr Val Tyr  Lys Asp Leu 
    1100                 1105                 1110             


Thr Gln  Arg Met Lys Ile Arg  Met Asn Gln Pro 
    1115                 1120                 


<210>  2730
<211>  1145
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2730

Met Thr Leu Pro Thr Asp Asn Thr Phe Ile Glu Lys Ala Asp Gln Glu 
1               5                   10                  15      


Ile Leu Gly Lys Asn Lys Leu Phe Phe Gly Ala Tyr Leu Asn Met Ala 
            20                  25                  30          


Asn His Asn Ala Tyr Leu Ile Ile Lys Asp Ile Ser Glu Arg Leu Lys 
        35                  40                  45              


Gln Glu Asp Ala Leu Asp Ile Asp Ala Pro Ser Asp Glu Asp Asn Leu 
    50                  55                  60                  


Ala Tyr Ala Asp Ile Phe Ser Lys Ile Leu Lys Lys Ala Ser Asp Lys 
65                  70                  75                  80  


Asn Pro Lys Asn Arg Pro Gln Ala Thr Ile Ile Asp Lys Val Thr Asn 
                85                  90                  95      


Leu Leu Ile His His Phe Pro Ala Phe Glu Val Phe Ala Tyr Glu His 
            100                 105                 110         


Pro Phe Glu Gln Gln Asn Ser Tyr Pro Glu Leu Leu Tyr Gln Lys Leu 
        115                 120                 125             


Thr Thr Ala Leu Lys Leu Leu Asn Asp Leu Arg Asn Glu His Ser His 
    130                 135                 140                 


Phe Tyr Tyr Lys Gly Ser Phe Asp Ile Asp Thr Val Phe Ser Ala Ala 
145                 150                 155                 160 


Gln Glu Glu Ile Thr Arg Phe Pro Tyr Leu Thr Pro Glu Asp Ile Glu 
                165                 170                 175     


Glu Leu Glu Tyr Tyr Lys Asn Asp Leu Leu Glu Pro Leu Thr Tyr Phe 
            180                 185                 190         


Lys Lys Tyr Gly Phe Val Phe Phe Ile Cys Thr Phe Leu Glu Lys Arg 
        195                 200                 205             


Tyr Ala Arg Tyr Met Leu Lys Glu Lys Gln Leu Asp Leu Ile Ala Ser 
    210                 215                 220                 


Asp Lys Glu Arg Asp Ala Thr Leu Glu Asn Phe Thr Asn Tyr Ser Cys 
225                 230                 235                 240 


Arg Leu Pro Arg Pro Lys Leu Glu Ser Ser Val Ile Glu Leu Asp Met 
                245                 250                 255     


Leu Asn Glu Leu Ser Arg Cys Pro Lys Gly Ile His Asp Val Leu Ser 
            260                 265                 270         


Ser Pro Met Glu Lys Val Leu Leu Lys Thr Asp Ala Lys Asp Asp Pro 
        275                 280                 285             


Asn Gln Val Pro Met Ile Arg His Asn Asp Arg Phe Pro Tyr Phe Ala 
    290                 295                 300                 


Leu Ser Tyr Phe Asp Lys Met Glu Arg Phe Pro Ala Met Arg Phe His 
305                 310                 315                 320 


Ile Trp Ala Gly Lys Thr Arg Leu Ala Phe Tyr Gly Lys Lys Leu Gly 
                325                 330                 335     


Lys Lys Asn Val Leu Arg Asp Ile Gln Glu Asn Val Thr Ile Tyr Ala 
            340                 345                 350         


Arg Leu Asn Asp Ile Lys Ala Asp Lys Ile Pro Asp Asn Trp Lys Asp 
        355                 360                 365             


Lys Ile Asp Val Glu Asp Ser Glu Glu Asn Lys Glu Lys Ala Lys Ile 
    370                 375                 380                 


Gln Ser Tyr Ser Pro His Tyr Asn Ile His Asn Asn Arg Ile Ala Ile 
385                 390                 395                 400 


Lys Phe Ile Asp Thr Gln Lys Asp Glu Leu Asp Thr Glu Asn Phe Ser 
                405                 410                 415     


Glu Ile Lys Ser Lys Pro Gln Asp Pro Thr Lys Asp Lys Gln Leu Lys 
            420                 425                 430         


Tyr Thr Val Thr His Ala Leu Pro Asn Ala Ile Leu Ser Thr Tyr Glu 
        435                 440                 445             


Leu Gln Asn Leu Phe Leu Tyr Asp Tyr Leu Tyr Arg Thr Tyr Lys Asp 
    450                 455                 460                 


Gln Lys Val Leu Ala Arg Pro Ala Asp Ser Phe Ile Arg Asn Tyr Ile 
465                 470                 475                 480 


Ser Ser Phe His Arg Phe Cys Lys Asp Val Lys Ser Gly Lys Ile Gln 
                485                 490                 495     


Pro Val Ser Pro His Asp Phe Glu Arg Leu Thr Glu His Thr Arg Ser 
            500                 505                 510         


Thr Thr Arg Asp Leu Gly Asn Arg Glu Glu Glu Leu Glu Ile Arg Lys 
        515                 520                 525             


Glu Ala Leu Gln Lys Lys Lys Leu Asp Asn Tyr Gly Leu Lys Val Lys 
    530                 535                 540                 


Asn Leu Pro Asp Ala Leu Arg Glu Tyr Leu Leu Gly Tyr Lys Gln Glu 
545                 550                 555                 560 


Thr Tyr Thr Glu Ile Ala Leu Asn Lys Leu Arg Gly Lys Ile Lys Gln 
                565                 570                 575     


Thr Lys Val His Tyr Lys Leu Ala Thr Lys Asp Asp Leu Phe Leu Asp 
            580                 585                 590         


Gly Lys Thr Asp Leu Lys Ser Gly Lys Ile Gly Asp Phe Leu Ala Ala 
        595                 600                 605             


Asp Ile Val Phe Leu Lys Pro Leu Asp Ala Asn Arg Thr Gly Lys Pro 
    610                 615                 620                 


Asn Asn Gln Gln Phe Asn Glu Leu Gln Lys Ala Ile Ala Arg Phe His 
625                 630                 635                 640 


Ser Gln Lys Lys Asp Val Glu Asp Phe Ile Asn Glu Glu Leu Gln Ile 
                645                 650                 655     


Lys Glu Gln Ser Leu Pro His Ala His Pro Phe Leu Tyr Lys Ile Gln 
            660                 665                 670         


Phe Glu Glu His Thr Asp Val Gln Ser Phe Tyr Ile Lys Tyr Leu Glu 
        675                 680                 685             


Leu Lys Ile Glu Trp Leu Glu Cys Thr Lys Arg Glu Ile Gln Gly Lys 
    690                 695                 700                 


Ser Asp Tyr Leu Lys Pro Trp Gln Trp Arg Glu Glu Ala Asp Lys Cys 
705                 710                 715                 720 


Lys Gln Tyr Gly Ile Asp Ile Lys Pro Glu Gly Leu Ser Asp Ala Ala 
                725                 730                 735     


Thr Glu Asn Lys Tyr Gly Tyr Phe Leu Gln Ile Asn Thr Lys Lys Gly 
            740                 745                 750         


Asn Glu Arg Asn Tyr Thr Asn Ala Thr Thr Pro Ser Lys Ala Asn Ser 
        755                 760                 765             


Lys Glu Phe Glu Ser Leu Glu Ser Lys Ser Pro Val Phe Leu Pro Arg 
    770                 775                 780                 


Gly Leu Phe Asn Asp Ala Ile Ile Asp Ala Met Met Lys Ile Asp Glu 
785                 790                 795                 800 


Phe Lys Gly Lys Ile Lys Glu Gly Asp Asn Ile Val Arg Cys Leu Asp 
                805                 810                 815     


Val Leu Ala Glu Gly Asp Arg Gln Thr Phe Tyr Asp Phe Glu Arg Ser 
            820                 825                 830         


Tyr Thr Val Gly Lys Ala Ala Pro Thr Ser Val Thr Ile His Gln Gly 
        835                 840                 845             


Ala Asn Gly Glu Tyr Ile Lys Asn Lys Leu Arg Ser Ile Lys Pro Ile 
    850                 855                 860                 


Ile Lys Lys Leu Arg Thr Gln Gln Asn Ala Lys Asp Ala Lys Tyr Lys 
865                 870                 875                 880 


Asp Lys Lys Ile Leu Gln Asn His Ile Lys Ala Leu Gln Ala Ile Ser 
                885                 890                 895     


Asp Asn Glu Arg Ser Ile Arg Phe Ile Arg Ala Asn Asp Arg Thr Leu 
            900                 905                 910         


Phe Leu Met Ile Lys His Ile Phe Ser Glu His Lys Ser Tyr Val Val 
        915                 920                 925             


Glu Gly Ser Lys Leu Thr Lys Ser Ile Asn Thr Leu Pro Trp Lys Leu 
    930                 935                 940                 


Asn Lys Val Gly Tyr Glu Ile Lys Glu Asn Asn Ile Leu Asn Glu Ile 
945                 950                 955                 960 


Leu Pro Met Asn Ile Gln Phe Asn Gln Lys Ser Ile Tyr Thr Glu Gly 
                965                 970                 975     


Glu His Gly Thr Asp Pro Leu Asn Lys Leu Ser Ile Lys His Tyr Gly 
            980                 985                 990         


Lys Phe Arg Lys Leu Leu Lys Asp  Lys Arg Leu Ser Asn  Lys Lys Lys 
        995                 1000                 1005             


Pro Gly  Leu Leu Asn Tyr Tyr  Thr Asp Gln Asn Val  Arg Trp Ser 
    1010                 1015                 1020             


Ala Ile  Asn Lys Glu Leu Glu  Tyr Tyr Asp Glu Asn  Arg Asp Arg 
    1025                 1030                 1035             


Leu Leu  Asp Val Ile Tyr Lys  Phe Glu Lys Ala Val  Trp Glu Asn 
    1040                 1045                 1050             


Glu Glu  Cys Arg Glu Glu Leu  Lys Glu Asn Ile Arg  Leu Gly Tyr 
    1055                 1060                 1065             


Ile Asn  His Ala Thr Gln Leu  Lys Ala Val Gly Lys  Ile Val Arg 
    1070                 1075                 1080             


Gly Phe  Thr Ala Ser Lys Gln  Asp Gln Leu Ala Leu  Leu Arg Asn 
    1085                 1090                 1095             


Lys Phe  Leu His Asn Gln Ile  Pro Tyr Thr Glu Asn  Leu Lys Thr 
    1100                 1105                 1110             


Gly Trp  Val Asp Asn Asn Pro  Glu Tyr Pro Leu Ile  Thr Gln Ala 
    1115                 1120                 1125             


Leu Leu  Glu Leu Ala Ile Ile  Glu Tyr Gln Asn Ile  Thr Lys Asn 
    1130                 1135                 1140             


Ile Ile  
    1145 


<210>  2731
<211>  1098
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2731

Met Glu Asn Leu Asn Lys Arg Thr Leu Thr Thr Asp Pro Gln Tyr Phe 
1               5                   10                  15      


Gly Gly Tyr Leu Asn Ser Ala Arg His Asn Ile Phe Thr Ile Ser Asn 
            20                  25                  30          


Tyr Ile Ala Glu Arg Ile Asn Pro Leu Met Lys Lys Gly Lys Leu Ser 
        35                  40                  45              


Ile Arg Lys Asp Asp Asp Glu Ile Ala Asp Ser Phe Ile Cys Thr Lys 
    50                  55                  60                  


Ile Ile Glu Lys Pro Asn Leu Phe Phe Thr Asn Leu Val Arg Phe Leu 
65                  70                  75                  80  


Pro Ile Val Lys Val Tyr Asp Ser Asp Lys Leu Pro Lys Ala Glu Lys 
                85                  90                  95      


Glu Lys Pro Ser Ser Glu Gly Ile Asp Phe Glu Thr Leu Ala Asp Asp 
            100                 105                 110         


Met Lys Ile Cys Phe Lys Glu Leu Asn Gly Phe Arg Asn Asp Tyr Ser 
        115                 120                 125             


His Tyr Phe Ser Lys Glu Thr Gly Thr Glu Arg Lys Ile Val Ile Asp 
    130                 135                 140                 


Glu Arg Leu Ser Val Phe Leu Arg Thr Asn Tyr Gln Arg Ala Ile Glu 
145                 150                 155                 160 


Tyr Thr Lys Ile Arg Phe Lys Asp Val Tyr Glu Glu Ser His Phe Lys 
                165                 170                 175     


Ile Ala Ala Asp Lys Ile Leu Val Asn Glu Ser Asn Val Ile Thr Gln 
            180                 185                 190         


Asp Gly Leu Val Phe Phe Thr Cys Leu Phe Leu Asp Arg Glu Asn Ala 
        195                 200                 205             


Phe His Phe Ile Asn Arg Ile Ile Gly Phe Lys Asp Thr Arg Thr Leu 
    210                 215                 220                 


Gly Phe Arg Ala Thr Arg Glu Val Phe Ser Ala Tyr Cys Val Thr Leu 
225                 230                 235                 240 


Pro His Asp Lys Phe Thr Ser Asp Asp Glu Lys Gln Gly Phe Ile Leu 
                245                 250                 255     


Asp Leu Leu Asn Glu Leu Asn Lys Cys Pro Lys Glu Leu Tyr Asp Asn 
            260                 265                 270         


Ile Thr Glu Glu Glu Arg Lys Ile Phe Arg Pro Asp Val Ser Glu Ser 
        275                 280                 285             


Ile Asp Lys Ile Thr Glu Ser Ser Ile Pro Glu Asp Leu Ala Phe Glu 
    290                 295                 300                 


Asp Tyr Asp Glu Tyr Ile Gln Ser Ile Ile Thr Lys Lys Arg Lys Ser 
305                 310                 315                 320 


Asp Arg Phe Pro Tyr Phe Ala Ile Lys Tyr Leu Asp Gly Lys Lys Asp 
                325                 330                 335     


Phe Asp Ile Asn Phe His Leu Asn Leu Gly Lys Val Glu Leu Leu Ser 
            340                 345                 350         


Arg Lys Lys Lys Phe Leu Gly Glu Glu Val Asp Arg Asp Ile Val Glu 
        355                 360                 365             


Asp Val Lys Val Phe Gly Lys Leu Ala Glu Tyr Thr Asn Glu Lys Glu 
    370                 375                 380                 


Val Ser Arg Lys Leu Gly Leu Glu Phe Gln Leu Phe Asn Pro His Tyr 
385                 390                 395                 400 


Gln Ile Glu Asn Asn Lys Met Gly Ile Ser Phe Ser Pro Lys Leu Cys 
                405                 410                 415     


Ser Val Lys Ser Glu Asn Asp Lys Pro Asn Leu Lys Leu Asn Pro Pro 
            420                 425                 430         


Asp Ala Phe Leu Ser Val His Glu Leu Pro Lys Ile Val Leu Ala Glu 
        435                 440                 445             


Leu Phe Glu Lys Gly Lys Ala Lys Glu Ile Ile Glu Ser Phe Ile Gly 
    450                 455                 460                 


Ile Asn Lys Asp Lys Ile Leu Asn Arg Glu Phe Ile Glu Glu Val Lys 
465                 470                 475                 480 


Ser Lys Leu Val Phe Glu Lys Pro Phe Tyr Arg Ser Phe Gln Ser Lys 
                485                 490                 495     


Arg Gly Ala Ala Tyr Asn Asp Lys Gly Leu Gln Ile Leu Lys Glu Arg 
            500                 505                 510         


Lys Thr Lys Leu Asn Glu Ile Leu Arg Glu Tyr Asn Leu Asn Asp Arg 
        515                 520                 525             


Gln Ile Pro Glu Arg Ile Leu Asp Tyr Trp Leu Asn Ile Asn Asp Val 
    530                 535                 540                 


Lys Ser Glu Ser Glu Ile Ala Asn Arg Ile Lys Ala Met Lys Lys Asp 
545                 550                 555                 560 


Cys Arg Asp Arg Val Lys Ala Lys Ala Lys Asn Lys Ala Pro Lys Ala 
                565                 570                 575     


Gly Glu Met Ala Thr Tyr Leu Ala Lys Asp Ile Val Asp Met Val Ile 
            580                 585                 590         


Asp Glu Lys Val Lys Gln Lys Ile Thr Ser Phe Tyr Tyr Asp Lys Met 
        595                 600                 605             


Gln Glu Cys Leu Ala Leu Tyr Gly Asp Asp Gly Lys Lys Gln Ile Phe 
    610                 615                 620                 


Ile Lys Met Cys Gly Glu Glu Leu Asn Leu Phe Asp Lys Glu Lys Gly 
625                 630                 635                 640 


His Pro Phe Leu Phe Asp Leu Asn Leu Gln Ser Ile Lys Lys Thr Ser 
                645                 650                 655     


Glu Phe Tyr Glu Lys Tyr Leu Ile Lys Lys Ala Lys Glu Lys Gln Asp 
            660                 665                 670         


Ile Trp Asn Ala Lys Thr Lys Lys Asn Gln Lys Val Glu Thr Asn Trp 
        675                 680                 685             


Leu Tyr Val Ser Phe Tyr Val Lys Val Trp Asn Glu Glu Lys Lys Lys 
    690                 695                 700                 


Met Glu Thr Lys Ile Gln Leu Pro Lys Asp Leu Ser Arg Ile Pro Phe 
705                 710                 715                 720 


Ser Ile Arg Asn Leu Ala Lys Glu Lys Ser Thr Leu Asp Lys Trp Leu 
                725                 730                 735     


Met Asn Val Ser Lys Gly Phe Val Glu Lys Asp Lys Ala Lys Pro Val 
            740                 745                 750         


Asp Leu Pro Thr Asn Ile Phe Asp Asp Thr Leu Val Ser Ile Leu Arg 
        755                 760                 765             


Glu Arg Leu Asn Gly Lys Lys Ile Leu Phe Lys Glu Thr Asp Arg Phe 
    770                 775                 780                 


Ser Arg Leu Leu Glu Leu Trp Cys Asn Asp Thr Gln Pro Phe Tyr Ser 
785                 790                 795                 800 


Ala Glu Arg Leu Tyr Asn Val Tyr Glu Lys Pro Val Lys Phe Lys Leu 
                805                 810                 815     


Gly Asp Lys Lys Ser Phe Lys Glu Tyr Phe Lys Glu Ile Ile Glu Lys 
            820                 825                 830         


Val Tyr Ser Glu Lys Asp Ala Glu Arg Lys Ser Glu Lys Gly Lys Pro 
        835                 840                 845             


Pro Ile Gln Lys Lys Asp Ile Leu Thr Val Phe Asn Asp Ala Ile Thr 
    850                 855                 860                 


Glu Asn Glu Lys Val Ile Arg Phe Tyr Gln Thr Lys Asp Arg Val Met 
865                 870                 875                 880 


Leu Phe Met Ile Asn Asp Leu Ile Gly Lys Asp Leu Asp Ile Ser Leu 
                885                 890                 895     


Lys Glu Ile Ser Pro Val Leu Glu Lys Ser Pro Leu Asn Val Glu Glu 
            900                 905                 910         


Glu Ile Lys Gln Arg Val Glu Gly Lys Leu Ser Tyr Asp Gly Glu Gly 
        915                 920                 925             


Asn Phe Ile Ser Lys Lys Glu Arg Thr Gln Asp Ile Ser Arg Ile Ile 
    930                 935                 940                 


Thr Asp Arg Arg Lys Arg Lys Asp Phe Thr Val Leu Lys Lys Phe Thr 
945                 950                 955                 960 


Phe Asp Lys Arg Leu Pro Glu Leu Phe Glu Tyr Tyr Thr Glu Glu Glu 
                965                 970                 975     


Val Pro His Glu Lys Leu Lys Thr Glu Leu Glu Glu Tyr Asn Gln Tyr 
            980                 985                 990         


Arg Glu Met Val Phe Asp Arg Ile  Phe Glu Leu Glu Lys  Lys Ile Ile 
        995                 1000                 1005             


Ala Lys  Gly Val Leu Lys Glu  Met Lys Gly Thr Gly  Lys Ser Asn 
    1010                 1015                 1020             


Val Gln  His Glu Pro Tyr Leu  Asn Trp Leu Arg Glu  Lys Gly Leu 
    1025                 1030                 1035             


Ile Asp  Glu Lys Gln Tyr Gly  Phe Leu Lys Val Met  Arg Asn Ser 
    1040                 1045                 1050             


Phe Ser  His Asn Gln Tyr Pro  Pro Lys Val Val Val  Glu Lys Asn 
    1055                 1060                 1065             


Leu Asp  Leu Lys Glu Gly Lys  Ile Thr Ser Gln Ile  Phe Lys Lys 
    1070                 1075                 1080             


Tyr Asp  Glu Glu Ile Thr Gly  Ile Leu Glu Lys Leu  Gln Arg Leu 
    1085                 1090                 1095             


<210>  2732
<211>  903
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2732

Met Glu Ser Gln Pro Lys Arg Thr Asp Gly Ile Thr Tyr Tyr Asp His 
1               5                   10                  15      


Lys Ser Asn Ser Asp Lys His Tyr Phe Gly Gly Tyr Leu Asn Gln Ala 
            20                  25                  30          


Leu Asn Asn Tyr Thr Val Ile Glu Lys Leu Phe Glu Gln Lys Phe Glu 
        35                  40                  45              


Glu Ser Leu Glu Asn Phe Leu Gln Lys Asn Lys Lys Val Ser Tyr Ala 
    50                  55                  60                  


Gln Trp Glu Arg Met Leu Asn Phe Leu Lys His His Phe Pro Val Val 
65                  70                  75                  80  


His Tyr Ile Asp Leu Pro Val Arg Glu Ala Thr Lys Asp Asn Pro Asp 
                85                  90                  95      


Pro Phe Pro Arg Asn Asp Ala Glu Arg Arg Gln His Phe Ile Thr Thr 
            100                 105                 110         


Phe Thr Ser Ile Lys Lys Leu Leu Phe Asp Leu Arg Asn Phe Tyr Ser 
        115                 120                 125             


His Tyr Phe His Glu Pro Ile Asp Thr Lys Ile Asp Thr Leu Ser His 
    130                 135                 140                 


Leu Asp Gln Ile Phe Val Ala Val Cys Glu His Val Lys Thr Lys Arg 
145                 150                 155                 160 


Met Lys Thr Asp Glu Thr Arg Leu Leu Leu Lys Glu Thr Leu Ala Asp 
                165                 170                 175     


Glu Leu Thr His Leu Phe Ile Leu Lys Glu Lys Glu Leu Leu Glu Leu 
            180                 185                 190         


Lys Lys Lys Val Gly Ile Thr Gly Lys Thr Thr Ala Glu Glu Val Arg 
        195                 200                 205             


Asn Ala Ile Phe Asn Asp Ser Phe Lys His Leu Tyr Tyr Glu Lys Gln 
    210                 215                 220                 


Pro Ser Arg Ile Tyr Arg Ser Ser Leu Gln Glu Glu Ala Ala Thr Glu 
225                 230                 235                 240 


Asn Gly Ile Thr Ile Ser Gln Ser Gly Leu Ser Leu Ile Leu Ser Phe 
                245                 250                 255     


Phe Leu Ser Lys Arg Glu Met Glu Gly Phe Lys Ser Arg Leu Arg Gly 
            260                 265                 270         


Leu Lys Gly Arg Val Leu Asn Leu Glu Asn Gly Asn Ile Asp Leu Arg 
        275                 280                 285             


Asn Asn Ser Leu Arg Phe Met Ala Thr His Trp Val Phe Ser Tyr Leu 
    290                 295                 300                 


Cys Phe Lys Gly Pro Asn Gln Lys Leu Asn Thr Ser Tyr Leu Glu Glu 
305                 310                 315                 320 


Thr Leu Leu Val Gln Ile Ile Asp Glu Leu Thr Lys Val Pro His Glu 
                325                 330                 335     


Val Tyr Glu Ala Leu His Val Val Gln Arg Asp Lys Phe Val Glu Asp 
            340                 345                 350         


Ile Asn Glu Phe Met Arg Gln Asp Leu Glu Asp Gly Ser Glu Glu Asn 
        355                 360                 365             


Ala Leu Val Val His Pro Val Ile Arg Lys Arg Cys Glu Asn Lys Phe 
    370                 375                 380                 


Asn Tyr Phe Ala Leu Arg Tyr Leu Asp Glu Phe Ala Gly Phe Lys Thr 
385                 390                 395                 400 


Leu Arg Phe Gln Ile Asn Ile Gly Asn Tyr Ile His Asp Arg Arg Ser 
                405                 410                 415     


Lys Glu Leu Lys Ser Gly Ser Phe Ile Thr Asp Arg Glu Val Lys Glu 
            420                 425                 430         


Arg Ile Asn Val Phe Gly Arg Leu Ser Ala Val Thr Thr Leu Lys Asp 
        435                 440                 445             


Asp Phe Phe Arg Ser Glu Ser Tyr Glu Gly Ser Ser Trp Glu Arg Phe 
    450                 455                 460                 


Pro Asn Pro Ser Tyr Asn Ile Asn Gly Asn Asn Ile Ala Ile Tyr Leu 
465                 470                 475                 480 


Asp Leu Gly Lys Asp His Gly Lys Asp Thr Lys Val Ile Tyr Asp Ala 
                485                 490                 495     


Arg Ser Lys Arg Asn Lys Lys Glu Glu Arg Val Asp Arg Ser Asn Gly 
            500                 505                 510         


Lys Pro Thr Lys Asp Asp Ile Leu Lys Glu Leu Gln Gln Ala Val Glu 
        515                 520                 525             


Val Lys Ser Asp Thr Ile His Arg Lys Glu Pro Thr Ala Leu Leu Ser 
    530                 535                 540                 


Leu His Glu Leu Pro Ala Leu Leu Tyr Glu Leu Leu Val Asn His Val 
545                 550                 555                 560 


Lys Pro Glu Thr Ile Glu Thr Ile Leu Ala Gly Lys Ile Ser Glu Arg 
                565                 570                 575     


Leu Lys Val Ile Gln Glu Tyr Thr Pro Gln Ser Asp Leu Pro Leu Ser 
            580                 585                 590         


Gln Ile Pro Lys Asn Leu Lys Val Ser Gly Gln Glu Pro Lys Val Gln 
        595                 600                 605             


Tyr Asp Lys Leu Ile Arg Leu Ile Asp Asn Leu Ile Ala Ala Gly Glu 
    610                 615                 620                 


Asp Lys Ser Ala Leu Ile Ser Lys Asn Gln Arg Glu Ile Ala Asn Pro 
625                 630                 635                 640 


Lys Ile Lys Arg Asn Phe Val Phe Thr Ile Thr Glu Arg Gly Arg Glu 
                645                 650                 655     


Ala Asn Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Glu Ser Thr 
            660                 665                 670         


Lys Gly Gln Trp Lys Gly Tyr His His Ser Gln Leu Gln Glu Ile Leu 
        675                 680                 685             


Ala Phe Tyr Phe Ala Arg Lys Gln Asp Ala Ile Ser Leu Leu Asn Ser 
    690                 695                 700                 


Val Trp Gln Leu Lys Gln Ser Asp Phe Gly Ala Ser Leu Glu Val Leu 
705                 710                 715                 720 


Phe Leu Lys Pro Gly Phe Asp Ser Phe Tyr Ile Ala Tyr Leu Gln Asn 
                725                 730                 735     


Arg Lys Glu His Leu Gly Gln Ile Arg Asp Arg Ile Leu Gln Tyr Gln 
            740                 745                 750         


Ser Glu Lys Asn Val Ile Lys Lys Val Leu Lys Ser Ile Asp His Ile 
        755                 760                 765             


Phe Pro Lys Lys Val Tyr Thr Ile Arg Ser Thr Gln Asp Gln Ile Glu 
    770                 775                 780                 


Asn Leu Leu Gly Lys Pro Ile Ala Phe Ser Arg Gly Ile Phe Asp Ser 
785                 790                 795                 800 


Lys Pro Thr Phe Ile Thr Asp Thr Thr Phe Glu Gly Asn Glu His Leu 
                805                 810                 815     


Phe Ala Asp Trp Tyr Arg Thr Ser Arg Asp Lys Ser Ile Ala Phe Gln 
            820                 825                 830         


Ser Phe Tyr Asn Leu Pro Lys Asp Tyr Ser Glu Leu Ile Ser His Ala 
        835                 840                 845             


Lys Glu Thr Gly Lys Arg Ile His Asp Leu Ser Ala Arg Val Lys Met 
    850                 855                 860                 


Asn Thr Asp Leu Asn Ile Lys Asn Val Gln Ile Lys Asp Phe Phe Leu 
865                 870                 875                 880 


Lys Lys Ile Ala Asp Ala Leu Phe Gln Lys Cys Leu Gly Gln Thr Phe 
                885                 890                 895     


Ala Asn Ser Glu Gly Asn Asp 
            900             


<210>  2733
<211>  1029
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2733

Met His Val Thr Thr Thr Asn Lys Pro Leu Leu Ala Ala Tyr Leu Asn 
1               5                   10                  15      


Met Ala Arg Asn Asn Cys Tyr Met Ala Leu Ser His Ile Ala Glu Leu 
            20                  25                  30          


Met Gly Lys Ser Ser Val Met Asn Glu Asp Ala Ile Gln Glu Cys Ala 
        35                  40                  45              


Val Ile Arg Ala Leu Ala Gly Asn Ile Lys Pro Asp Glu Ser Phe Arg 
    50                  55                  60                  


Ile Ile Asp Met Val Asp Gln His Phe Pro Phe Ile Arg Leu Leu Leu 
65                  70                  75                  80  


Lys Ser Arg Asn Asn Ser Ser Pro Thr Asp Tyr Ala Asn Cys Leu Thr 
                85                  90                  95      


Asp Phe Ile Lys Gln Leu Asn Glu Leu Arg Asn Phe His Thr His Gln 
            100                 105                 110         


Leu His Lys Pro Tyr Ile Thr Asp Ala Lys Val Val Ala Gln Leu Gln 
        115                 120                 125             


Phe Leu Phe Asp Ala Ser Arg Arg Glu Val Lys Lys Arg Phe Ser Leu 
    130                 135                 140                 


Glu Glu Gln Asp Val Lys His Leu Val Arg Lys Ser Ile Val Ile Ile 
145                 150                 155                 160 


Asp Asn Asn Lys Val Ala Val Glu Lys Glu Asn Tyr Val Tyr Ala Phe 
                165                 170                 175     


Ala Asn Lys Glu Gly Gln Phe Thr Asn Lys Gly Ile Ala Phe Leu Ile 
            180                 185                 190         


Ser Leu Phe Ile Glu Lys Lys Tyr Ala Tyr Leu Phe Leu Lys Gln Leu 
        195                 200                 205             


Ser Gly Phe Lys Asn Ser Asn Thr Lys Gln His Lys Ala Thr Leu Glu 
    210                 215                 220                 


Val Phe Cys Phe Tyr His Ile Arg Ile Pro Gln Pro Lys Leu Gln Ser 
225                 230                 235                 240 


Asn Asn Thr Lys Ile Gly Phe Leu Leu Asp Ala Leu Glu Glu Leu Lys 
                245                 250                 255     


Arg Cys Pro Ala Glu Leu Tyr Glu His Ile Ala Lys Asn Asp Lys Gln 
            260                 265                 270         


Arg Phe Lys Ser Ala Gly Ile Thr Glu Asp Thr Asn Asp Gln Pro Glu 
        275                 280                 285             


Ala Ile Leu Lys Arg Asn Gly Asp Arg Phe Ser Tyr Leu Ala Leu Arg 
    290                 295                 300                 


Tyr Leu Glu Leu Thr Asn Ser Leu Pro Gly Leu Gln Phe Tyr Phe Asp 
305                 310                 315                 320 


Leu Gly Lys Tyr Tyr Phe Lys Val Tyr Glu Lys Ser Ile Asp Ser Glu 
                325                 330                 335     


Leu Arg Leu Arg Arg Leu His Lys Asn Met Arg Asp Phe Gly Arg Thr 
            340                 345                 350         


Asn Asp Phe Asp Thr Val Lys Met Pro Gln Leu Trp Gln Gln Leu Ile 
        355                 360                 365             


Lys Arg Thr Asp Glu Leu Ser Glu Asn Tyr Ala Glu Pro Tyr Ile Val 
    370                 375                 380                 


Tyr Thr Ile Pro His Tyr His Ile Val Asn Asn Gln Ile Gly Ile Trp 
385                 390                 395                 400 


Leu Asn Lys Glu Arg Gln Met Pro Ser Leu Thr Pro Lys Ile Ser Asn 
                405                 410                 415     


Ala Glu Pro Gln Ile Trp Leu Ser Leu Tyr Glu Leu Pro Ala Leu Leu 
            420                 425                 430         


Phe Tyr His Leu Leu Thr Lys Gly Asn Lys Gly Gln Lys Asn Val Leu 
        435                 440                 445             


Gln Ile Leu Ser Lys His Arg Thr Ala Ile His Ser Phe Phe Lys Asp 
    450                 455                 460                 


Ile Glu Ser Ser Lys Leu Leu Pro Gly Phe Thr Ile Glu Thr Leu Asn 
465                 470                 475                 480 


Val Glu Leu Glu Lys Arg Asn Leu Lys His Asp Lys Ile Pro Lys Pro 
                485                 490                 495     


Leu Leu Gln Tyr Leu Leu Gln Gln Lys Pro Leu Lys Ser Ile Val Glu 
            500                 505                 510         


Ile Ala Gly Glu Arg Leu Ser Glu Leu Gln Asn Glu Thr Ile Phe Leu 
        515                 520                 525             


Leu Asp Lys Ile Asp Ile Asp Ile Glu Lys Ala Lys Glu Lys Ile Gly 
    530                 535                 540                 


Gly Lys His Tyr Arg Pro Ile Gln Thr Gly Lys Ile Ala Asp Phe Leu 
545                 550                 555                 560 


Ala Arg Asp Met Leu Phe Phe Gln Pro Ala Ile Asp Lys Ile Lys Gly 
                565                 570                 575     


Lys Ala Thr Ser Thr Leu Phe Gln Val Leu Gln Ala Arg Leu Ala Phe 
            580                 585                 590         


Tyr Gly Arg Asp Lys Glu Leu Leu Glu Gly Leu Tyr Lys Glu Cys Asn 
        595                 600                 605             


Leu Ile Gln Ser Lys Asn Pro His Pro Phe Leu Ser Gly Leu Pro Ile 
    610                 615                 620                 


Thr Asn Asn Leu Met Asp Tyr Tyr Arg Asn Tyr Leu Ile Lys Arg Asn 
625                 630                 635                 640 


Gln Tyr Leu Asp Lys Cys Leu Lys Lys Cys Lys Gln Gly Lys Ile Gly 
                645                 650                 655     


Ser Gln Asp Phe His Phe Leu His Leu Gly Glu Arg Glu Arg Lys Asn 
            660                 665                 670         


Gly Asn Thr Tyr Tyr Thr Asn Leu Ala Gly Lys Phe Ile Lys Met Pro 
        675                 680                 685             


Leu Asn Phe Pro Arg Gly Leu Phe Met Glu Glu Leu Ile Asn Tyr Phe 
    690                 695                 700                 


Glu Ser Ser Gly Asp Leu His Met Gln Asn Ile Ile Lys Asn Thr Pro 
705                 710                 715                 720 


Arg Leu Ser Thr Thr Phe Leu Leu Lys Glu Tyr Ile Asn Asn Val Leu 
                725                 730                 735     


Ser Asp Asp Thr Pro Asp Phe Tyr Asn Trp Lys Arg Ser Tyr Thr Val 
            740                 745                 750         


Phe Asn Arg Tyr Tyr Asp Lys Arg Lys Gln Asn Ser Arg Asp Ala Ile 
        755                 760                 765             


Thr Lys Ile Tyr Phe Asp Thr Ser Gln Leu Ser Glu Glu Ala Asn Lys 
    770                 775                 780                 


Ile Lys Ala Ala Ile Lys Lys Ile Glu Lys Ser Asp Ile Lys Gly Ala 
785                 790                 795                 800 


Glu Ser Ile Lys Arg Asn Tyr Lys Phe Tyr Gly Asp Asn Glu Lys Gln 
                805                 810                 815     


Leu Arg Gln Ala Lys Ala Cys Asp Thr Ile Leu Phe Leu Ala Ile Arg 
            820                 825                 830         


Asp Leu Phe Pro Thr Ile Glu Ser Ser Val Phe Lys Gly Leu Ala Ile 
        835                 840                 845             


Glu Gln Phe Arg Leu Ser Asp Ile Leu Pro Asp Ala Glu Lys Gly Ile 
    850                 855                 860                 


Leu Ser Gln Ser Ile Glu Ile Arg Leu Pro Leu Tyr Asn Lys Phe Ile 
865                 870                 875                 880 


Ile Gln Lys Gly Leu Lys Leu Lys Asn Tyr Gly Asp Phe Arg Arg Phe 
                885                 890                 895     


Leu Lys Asp Arg Arg Leu Glu Ser Leu Met Pro Tyr Phe Glu Glu Asp 
            900                 905                 910         


Asp Ile Asp Arg Ser Ser Leu Glu Lys Glu Leu Glu Asp Tyr Asp Thr 
        915                 920                 925             


Ala Arg Ile Glu Ile His Arg Val Val Leu Asp Phe Glu Ser His Val 
    930                 935                 940                 


Ile Thr Met Tyr Gln Leu Asn Tyr Leu Asn Pro Glu Asp Pro Cys Ile 
945                 950                 955                 960 


Asn His Glu Thr Ile Leu Asn Cys Phe Phe Gln Asn Asp Pro Ser Asp 
                965                 970                 975     


Ile Arg Lys Gln Leu Met Glu Asn Ile Arg Asn Arg Phe Ser His Asn 
            980                 985                 990         


Glu Tyr Pro Asp Phe Glu Lys Phe  Lys Glu Ile Ile Gln  Glu Asn His 
        995                 1000                 1005             


Gln Gln  Lys Thr Ile Ala Gly  Lys Phe Val Thr Leu  Ala Asn Gln 
    1010                 1015                 1020             


Tyr Phe  Ser Val Glu Glu 
    1025                 


<210>  2734
<211>  1029
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2734

Met His Val Thr Thr Thr Asn Lys Pro Leu Leu Ala Ala Tyr Leu Asn 
1               5                   10                  15      


Met Ala Arg Asn Asn Cys Tyr Met Ala Leu Ser His Ile Ala Glu Leu 
            20                  25                  30          


Met Gly Lys Ser Ser Val Met Asn Glu Asp Ala Ile Gln Glu Cys Ala 
        35                  40                  45              


Val Ile Arg Ala Leu Ala Gly Asn Ile Lys Pro Asp Glu Ser Phe Arg 
    50                  55                  60                  


Ile Ile Asp Met Val Asp Gln His Phe Pro Phe Ile Arg Leu Leu Leu 
65                  70                  75                  80  


Lys Ser Arg Asn Asn Ser Ser Pro Thr Asp Tyr Ala Asn Cys Leu Thr 
                85                  90                  95      


Asp Phe Ile Lys Gln Leu Asn Glu Leu Arg Asn Phe His Thr His Gln 
            100                 105                 110         


Leu His Lys Pro Tyr Ile Thr Asp Ala Lys Val Val Ala Gln Leu Gln 
        115                 120                 125             


Phe Leu Phe Asp Ala Ser Arg Arg Glu Val Lys Lys Arg Phe Ser Leu 
    130                 135                 140                 


Glu Glu Gln Asp Val Lys His Leu Val Arg Lys Ser Ile Val Ile Ile 
145                 150                 155                 160 


Asp Asn Asn Lys Val Ala Val Glu Lys Glu Asn Tyr Val Tyr Ala Phe 
                165                 170                 175     


Ala Asn Lys Glu Gly Gln Phe Thr Asn Lys Gly Ile Ala Phe Leu Ile 
            180                 185                 190         


Ser Leu Phe Ile Glu Lys Lys Tyr Ala Tyr Leu Phe Leu Lys Gln Leu 
        195                 200                 205             


Ser Gly Phe Lys Asn Ser Asn Thr Lys Gln His Lys Ala Thr Leu Glu 
    210                 215                 220                 


Val Phe Cys Phe Tyr His Ile Arg Ile Pro Gln Pro Lys Leu Gln Ser 
225                 230                 235                 240 


Asn Asn Thr Lys Ile Gly Phe Leu Leu Asp Ala Leu Glu Glu Leu Lys 
                245                 250                 255     


Arg Cys Pro Ala Glu Leu Tyr Glu His Ile Ala Lys Asn Asp Lys Gln 
            260                 265                 270         


Arg Phe Lys Ser Ala Gly Ile Thr Glu Asp Thr Asn Asp Gln Pro Glu 
        275                 280                 285             


Ala Ile Leu Lys Arg Asn Gly Asp Arg Phe Ser Tyr Leu Ala Leu Arg 
    290                 295                 300                 


Tyr Leu Glu Leu Thr Asn Ser Leu Pro Gly Leu Gln Phe Tyr Phe Asp 
305                 310                 315                 320 


Leu Gly Lys Tyr Tyr Phe Lys Val Tyr Glu Lys Ser Ile Asp Ser Glu 
                325                 330                 335     


Leu Arg Leu Arg Arg Leu His Lys Asn Met Arg Asp Phe Gly Arg Thr 
            340                 345                 350         


Asn Asp Phe Asp Thr Val Lys Met Pro Gln Leu Trp Gln Gln Leu Ile 
        355                 360                 365             


Lys Arg Thr Asp Glu Leu Ser Glu Asn Tyr Ala Glu Pro Tyr Ile Val 
    370                 375                 380                 


Tyr Thr Ile Pro His Tyr His Ile Val Asn Asn Gln Ile Gly Ile Trp 
385                 390                 395                 400 


Leu Asn Lys Glu Arg Gln Met Pro Ser Leu Thr Pro Lys Ile Ser Asn 
                405                 410                 415     


Ala Glu Pro Gln Ile Trp Leu Ser Leu Tyr Glu Leu Pro Ala Leu Leu 
            420                 425                 430         


Phe Tyr His Leu Leu Thr Lys Gly Asn Lys Gly Gln Lys Asn Val Leu 
        435                 440                 445             


Gln Ile Leu Ser Lys His Arg Thr Ala Ile His Ser Phe Phe Lys Asp 
    450                 455                 460                 


Ile Glu Ser Ser Lys Leu Leu Pro Gly Phe Thr Ile Glu Thr Leu Asn 
465                 470                 475                 480 


Val Glu Leu Glu Lys Arg Asn Leu Lys His Asp Lys Ile Pro Lys Pro 
                485                 490                 495     


Leu Leu Gln Tyr Leu Leu Gln Gln Lys Pro Leu Lys Ser Ile Val Glu 
            500                 505                 510         


Ile Ala Gly Glu Arg Leu Ser Glu Leu Gln Asn Glu Thr Ile Phe Leu 
        515                 520                 525             


Leu Asp Lys Ile Asp Ile Asp Ile Glu Lys Ala Lys Glu Lys Ile Gly 
    530                 535                 540                 


Gly Lys His Tyr Arg Pro Ile Gln Thr Gly Lys Ile Ala Asp Phe Leu 
545                 550                 555                 560 


Ala Arg Asp Met Leu Phe Phe Gln Pro Ala Ile Asp Lys Ile Lys Gly 
                565                 570                 575     


Lys Ala Thr Ser Thr Leu Phe Gln Val Leu Gln Ala Arg Leu Ala Phe 
            580                 585                 590         


Tyr Gly Arg Asp Lys Glu Leu Leu Glu Gly Leu Tyr Lys Glu Cys Asn 
        595                 600                 605             


Leu Ile Gln Ser Lys Asn Pro His Pro Phe Leu Ser Gly Leu Pro Ile 
    610                 615                 620                 


Thr Asn Asn Leu Met Asp Tyr Tyr Arg Asn Tyr Leu Ile Lys Arg Asn 
625                 630                 635                 640 


Gln Tyr Leu Asp Lys Cys Leu Lys Lys Cys Lys Gln Gly Lys Ile Gly 
                645                 650                 655     


Ser Gln Asp Phe His Phe Leu His Leu Gly Glu Arg Glu Arg Lys Asn 
            660                 665                 670         


Gly Asn Thr Tyr Tyr Thr Asn Leu Ala Gly Lys Phe Ile Lys Met Pro 
        675                 680                 685             


Leu Asn Phe Pro Arg Gly Leu Phe Met Glu Glu Leu Ile Asn Tyr Phe 
    690                 695                 700                 


Glu Ser Ser Gly Asp Leu His Met Gln Asn Ile Ile Lys Asn Thr Pro 
705                 710                 715                 720 


Arg Leu Ser Thr Thr Phe Leu Leu Lys Glu Tyr Ile Asn Asn Val Leu 
                725                 730                 735     


Ser Asp Asp Thr Pro Asp Phe Tyr Asn Trp Lys Arg Ser Tyr Thr Val 
            740                 745                 750         


Phe Asn Arg Tyr Tyr Asp Lys Arg Lys Gln Asn Ser Arg Asp Ala Ile 
        755                 760                 765             


Thr Lys Ile Tyr Phe Asp Thr Ser Gln Leu Ser Glu Glu Ala Asn Lys 
    770                 775                 780                 


Ile Lys Ala Ala Ile Lys Lys Ile Glu Lys Ser Asp Ile Lys Gly Ala 
785                 790                 795                 800 


Glu Ser Ile Lys Arg Asn Tyr Lys Phe Tyr Gly Asp Asn Glu Lys Gln 
                805                 810                 815     


Leu Arg Gln Ala Lys Ala Cys Asp Thr Ile Leu Phe Leu Ala Ile Arg 
            820                 825                 830         


Asp Leu Phe Pro Thr Ile Glu Ser Ser Val Phe Lys Gly Leu Ala Ile 
        835                 840                 845             


Glu Gln Phe Arg Leu Ser Asp Ile Leu Pro Asp Ala Glu Lys Gly Ile 
    850                 855                 860                 


Leu Ser Gln Ser Ile Glu Ile Arg Leu Pro Leu Tyr Asn Lys Phe Ile 
865                 870                 875                 880 


Ile Gln Lys Gly Leu Lys Leu Lys Asn Tyr Gly Asp Phe Arg Arg Phe 
                885                 890                 895     


Leu Lys Asp Arg Arg Leu Glu Ser Leu Met Pro Tyr Phe Glu Glu Asp 
            900                 905                 910         


Asp Ile Asp Arg Ser Ser Leu Glu Lys Glu Leu Glu Asp Tyr Asp Thr 
        915                 920                 925             


Ala Arg Ile Glu Ile His Arg Val Val Leu Asp Phe Glu Ser His Val 
    930                 935                 940                 


Ile Thr Met Tyr Gln Leu Asn Tyr Leu Asn Pro Glu Asp Pro Cys Ile 
945                 950                 955                 960 


Asn His Glu Thr Ile Leu Asn Cys Phe Phe Gln Asn Asp Pro Ser Asp 
                965                 970                 975     


Ile Arg Lys Gln Leu Met Glu Asn Ile Arg Asn Arg Phe Ser His Asn 
            980                 985                 990         


Glu Tyr Pro Asp Phe Glu Lys Phe  Lys Glu Ile Ile Gln  Glu Asn His 
        995                 1000                 1005             


Gln Gln  Lys Thr Ile Ala Gly  Lys Phe Val Thr Leu  Ala Asn Gln 
    1010                 1015                 1020             


Tyr Phe  Ser Val Glu Glu 
    1025                 


<210>  2735
<211>  994
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2735

Met Asp Ser Lys Tyr Ile Leu Gly Ser Tyr Leu Asn Met Ala Asn Asp 
1               5                   10                  15      


Asn Phe Ile Asn Thr Ile His Leu Leu Ala Lys Lys Leu Lys Thr Pro 
            20                  25                  30          


Lys Gly Glu Asp Gln Asn Leu Asp Gln Val Val Ser Tyr Ile Thr Arg 
        35                  40                  45              


Ile Phe Asp Asn Ser Asn Gln Val Pro Glu Thr Glu Gln Ile Val Glu 
    50                  55                  60                  


Phe Tyr Phe Pro Trp Leu Glu Ala Leu Lys Asn Ala Asn Gly Phe Gly 
65                  70                  75                  80  


Lys Ser Glu Leu Pro Glu Leu Lys Ile Phe Tyr Lys Asp Val Leu Cys 
                85                  90                  95      


Ser Phe Ala Glu Asn Leu Lys Asp Leu Arg Asn Asn Tyr Thr His Tyr 
            100                 105                 110         


Ile His Lys Thr Ile Ser Tyr His Pro Ile Ile Tyr Lys Lys Glu Gly 
        115                 120                 125             


Asn Thr Leu Gln Ser Ser Leu Pro Lys Ala Leu Leu Gln Ile Tyr Asp 
    130                 135                 140                 


Ala Ser Ile Lys Leu Ala Lys Glu Arg Phe Ser Ala Asp Glu Asn Ala 
145                 150                 155                 160 


Val Thr His Leu Arg Arg Tyr Lys Ile Val Gly Lys Lys Val Val Arg 
                165                 170                 175     


Lys Thr Glu Ala Asp His Phe Met Tyr Leu Leu Glu Lys Asp His Leu 
            180                 185                 190         


Leu Thr Glu Lys Gly Ile Ala Phe Phe Thr Ser Leu Phe Leu Asn Arg 
        195                 200                 205             


Lys Tyr Gly Tyr Leu Met Leu Lys Gln Leu Lys Gly Phe Lys Gln Gly 
    210                 215                 220                 


Gly Thr Leu Ala Tyr Arg Leu Thr Leu Glu Thr Phe Leu Ala Tyr Ser 
225                 230                 235                 240 


Asn Ile Lys Pro Val Glu Arg Leu Lys Ala Asp Lys Tyr Ser Asp Val 
                245                 250                 255     


Ala Phe Ile Met Asp Leu Leu Gly Glu Ile Ser Lys Ile Pro Lys Glu 
            260                 265                 270         


Leu Tyr His Ile Leu Pro Glu Thr Tyr Ile Leu Gln Tyr Lys Asn Lys 
        275                 280                 285             


Leu His Ile Glu Leu Asn Glu Asp Ile Ser Leu Glu Ala Tyr Cys Ser 
    290                 295                 300                 


Arg Gly Arg Asn Arg Phe Asp Gln Leu Ala Leu Thr Tyr Leu Asp Arg 
305                 310                 315                 320 


Leu Glu Asp Phe Lys Gln Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr 
                325                 330                 335     


Ile His Asn Gly Tyr Met Lys Ala Arg Ile Asp Gly Thr Glu Gln Glu 
            340                 345                 350         


Arg Tyr Leu Ser Glu Lys Met Tyr Gly Cys Cys Lys Asn Ile Tyr Arg 
        355                 360                 365             


Asp Leu Ser Ala Ile Val Ala Lys Gln Tyr Asn Ile Glu Val Lys Asp 
    370                 375                 380                 


Ser Thr Glu Thr Ser Tyr Met Leu Pro Asn Asp Phe Gln Pro His Val 
385                 390                 395                 400 


Ile Arg Ala Tyr Pro His Tyr Val Ile Asn Asn Asn Asn Ile Gly Ile 
                405                 410                 415     


Arg Leu Leu Asp Glu Gly Glu Ser Gly Phe Pro Ile Leu Glu Asn Arg 
            420                 425                 430         


Gly Thr Lys Asn Val Val Pro His Phe Trp Met Ser Lys Tyr Asp Leu 
        435                 440                 445             


Pro Ala Leu Leu Phe Tyr Ala Tyr Leu Arg Ser Asp Ser Arg Phe Ala 
    450                 455                 460                 


Ser Lys Cys Lys Lys Thr Ile Asp Glu Ile Leu Arg Gly Tyr Leu Ser 
465                 470                 475                 480 


Lys Ser Lys Asp Lys Lys Pro Lys Gln Ala Glu Lys Ala Ser Val Leu 
                485                 490                 495     


Met Leu Arg Arg Ile Asp Lys Ala Ile Ile Trp Thr Gln Thr Lys Leu 
            500                 505                 510         


Asn Glu Ala Glu Lys Gln Arg Asp Asn Lys Lys Ser Phe Lys Ile Gly 
        515                 520                 525             


Glu Lys Ala Asp Ile Leu Ala His Asp Met Leu Trp Leu Gln Pro Ala 
    530                 535                 540                 


Lys Glu Ser Lys Asp Lys Val Ser Gly Ala Asn Phe Arg Ala Leu Gln 
545                 550                 555                 560 


Thr Ser Leu Ala Phe Phe Lys Arg Asn Glu Leu Glu Asp Ile Phe Lys 
                565                 570                 575     


Arg Ser Phe Leu Ile Gly Gly Asn Asn Pro His Pro Phe Leu Ser Arg 
            580                 585                 590         


Ile Lys Ile Asn Thr Met Pro Ser Leu Phe Asp Phe Tyr Leu Ala Tyr 
        595                 600                 605             


Met Arg Glu Arg Leu Asn Tyr Leu Gly Lys Ile Lys Leu Lys Leu Leu 
    610                 615                 620                 


Lys Gly His Ile Asn Val Ser Cys His Pro Leu Arg Lys Leu Asn His 
625                 630                 635                 640 


Glu Lys Leu Val Asp Gln Asp Asn Lys Lys Asp Glu Gln Pro Ile Phe 
                645                 650                 655     


Leu Pro Arg Gly Ile Phe Asn Asp Val Ile Lys Asn Cys Leu Gln Lys 
            660                 665                 670         


Thr Lys Leu Gly Ile Tyr Leu Lys Asp Gln Gly Ala Glu Thr Arg Ser 
        675                 680                 685             


Trp Asn Val Ala Tyr Gln Ile Leu Lys Phe His Glu Ile Ile Asn Asp 
    690                 695                 700                 


Asp Asp Ile Gln Glu Phe Tyr Lys Gln Pro Arg Lys Tyr Ala Ile Leu 
705                 710                 715                 720 


Asp Glu Asn His Tyr Leu Thr Leu Glu Glu Arg Thr Asp Arg Leu Lys 
                725                 730                 735     


Asp Leu Lys Pro Glu Cys Ile Glu Val Ser Lys Ala Asn Asp Ile Leu 
            740                 745                 750         


Glu Lys Glu Asp Tyr Leu Leu Arg Lys Ser Tyr Asn Gln Val Cys Asp 
        755                 760                 765             


Asn Glu Ser Ala Ile Arg Leu Tyr Gln Val Gln Asp Ile Leu Leu Phe 
    770                 775                 780                 


Met Ile Ala Gln Arg Leu Cys Asn Glu Ile Ile Leu Gly Asp Lys Gln 
785                 790                 795                 800 


Glu Lys Lys Glu Lys Val Glu Thr Ser Phe Ser Leu Thr Leu Lys Asn 
                805                 810                 815     


Leu Ser Lys Lys Phe Asp Gln Pro Val His Phe Glu Ile Lys Met Thr 
            820                 825                 830         


Asn Val Asn Leu Phe Ser Asp Thr Asp Ile Pro Val Lys Asn Phe Gly 
        835                 840                 845             


Lys Met Leu Arg Leu Lys Lys Asp Ala Arg Phe Ile Ser Tyr Asn Lys 
    850                 855                 860                 


Leu Phe Asn Cys Gln Lys Gln Asn Ile Asn Tyr Asn Asp Tyr Cys Lys 
865                 870                 875                 880 


Glu Glu Glu Tyr Phe Asp Ile Cys Arg Ile Gln Thr Ile Lys Leu Cys 
                885                 890                 895     


His Glu Leu Glu Glu Lys Leu Leu Glu Lys Gly Ile Ile Thr Glu Ser 
            900                 905                 910         


Pro Asp Ser Gly Tyr Tyr Pro Phe Ala Asp Leu Val Gln Arg Ile Ile 
        915                 920                 925             


Asn Gln Gly Val Val Ile Cys Ser Ser Asp Val Lys Phe Ile Leu Glu 
    930                 935                 940                 


Ala Arg Asn Thr Phe Leu His Asn Glu Tyr Lys Gln Cys Cys Val Asn 
945                 950                 955                 960 


Ser Ile Asn Ser Ile Asp Ser Phe Ile Ala Glu Lys Val Tyr Asn Leu 
                965                 970                 975     


Phe Lys Gln Lys Met Asp Asn Ile Leu Gly Gln Leu Glu Ser Ile Lys 
            980                 985                 990         


Pro Ser 
        


<210>  2736
<211>  962
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2736

Met Lys Ile Pro Gln Ile Ile Glu Asp Asn Lys His Leu Phe Gly Thr 
1               5                   10                  15      


Tyr Ser Thr Met Ala Leu Ala Asn Ile Arg Asn Ile Leu Asp His Ile 
            20                  25                  30          


Ala Thr Leu Ala Cys Ile Glu Asn Asp Phe Asn Ala Asp Ser Asp Asp 
        35                  40                  45              


Phe Trp His His Pro Cys Met Glu Ile Ile Asn Pro Gln Asn Leu Cys 
    50                  55                  60                  


Asn Asp Val Thr Lys Ala Asp Phe Val Thr Glu Lys Leu Lys Ser His 
65                  70                  75                  80  


Phe Pro Phe Val Val Ile Met Ala Glu Ala Lys Arg Gln Lys Asp Ile 
                85                  90                  95      


Ala Trp Ala Lys Asn Gln Ala Lys Lys Ala Phe Glu Asn Arg Asp Phe 
            100                 105                 110         


Gln Lys Gln Gln Glu Phe Asn Lys Lys Gln Lys Ser Leu Leu Ser Ile 
        115                 120                 125             


Thr Asn Ala Asp Ile Tyr Arg Val Leu Asn Asn Leu Phe Arg Val Leu 
    130                 135                 140                 


Thr Ser Tyr Arg His Tyr Thr Ser His Tyr Leu Ile Asn Tyr Ile Tyr 
145                 150                 155                 160 


Phe Asn Glu Gly Ser Asn Leu Leu Lys Tyr His Glu Gln Pro Leu Ser 
                165                 170                 175     


Tyr Asn Ile Asn Asp Tyr Phe Thr Ile Ala Leu Arg Asp Thr Ala Gln 
            180                 185                 190         


Lys Tyr Ser Tyr Ser Pro Glu Ala Leu Ser Phe Ile Gln Ser Ser Arg 
        195                 200                 205             


Tyr Lys Ile Glu Asn Arg Arg Lys Ile Leu Asp Thr Asp Phe Phe Leu 
    210                 215                 220                 


Ser Ile Gln His Arg Asn Gly Asp Ser Ser Pro Lys Asn Leu His Ile 
225                 230                 235                 240 


Ser Gly Val Gly Val Ala Leu Leu Ile Cys Leu Phe Leu Glu Lys Lys 
                245                 250                 255     


Tyr Val Asn Val Phe Leu Gln Lys Leu Pro Ile Tyr Gly Thr Tyr Lys 
            260                 265                 270         


Lys Gln Ser Met Glu Ala Asn Ile Ile Arg Gln Thr Phe Gly Ile His 
        275                 280                 285             


Thr Ala Lys Leu Pro Lys Glu Arg Ile Val Ser Glu Lys Ser Asp Phe 
    290                 295                 300                 


Ser Ile Gly Met Asp Met Leu Asn Glu Leu Lys Arg Cys Pro Lys Ala 
305                 310                 315                 320 


Leu Phe Ser Thr Leu Ser Tyr Ala Asp Gln Asn Ala Phe Arg Ile Val 
                325                 330                 335     


Ser Ser Asp Leu Asn Asp Val Leu Gln Val Arg His Thr Asp Arg Phe 
            340                 345                 350         


Ala Gln Leu Ser Leu Glu Tyr Ile Asp Arg Arg Glu Leu Phe Ser Asp 
        355                 360                 365             


Ile Arg Phe His Leu Asn Met Gly Lys Leu Arg Tyr Leu Lys Thr Ala 
    370                 375                 380                 


Asp Lys His Cys Ile Asp Gly Ile Ser Arg Val Arg Val Leu Glu Asp 
385                 390                 395                 400 


Lys Ile Asn Ala Phe Gly Arg Ile His Glu Gln Gly Gly Arg Ala Ile 
                405                 410                 415     


Ser Thr Asn Thr Asn Ile Glu Ile Arg Asp Phe Glu His Val Lys Arg 
            420                 425                 430         


Asp Asp Ser Asn Pro Asp Ser Tyr Pro Tyr Ile Ile Asp Thr Tyr Thr 
        435                 440                 445             


His Tyr Ile Leu Glu Asn Asn Lys Ile Gly Met His Ile Gly Asp Tyr 
    450                 455                 460                 


Trp Pro Asp Leu Ile Lys Leu Asp Glu His Lys Trp Thr Val Tyr Asn 
465                 470                 475                 480 


Glu Asn Pro Thr Cys Phe Met Ser Ser Leu Glu Leu Pro Ala Met Met 
                485                 490                 495     


Phe His Met Met Leu Cys Gly Ser Asp Ala Thr Glu Ser Leu Ile Lys 
            500                 505                 510         


Ala Glu Val Asp Lys Tyr Lys Lys Leu Phe Gly Ala Met Ala Asn Gly 
        515                 520                 525             


Thr Leu Thr Lys Glu Asn Ile Ser Gly Phe Gly Ile Ala Glu Glu Asn 
    530                 535                 540                 


Ile Pro Gln Lys Val Ile Asp Cys Val Asn Gly Lys Thr Ser Gly Lys 
545                 550                 555                 560 


Gly Leu Asp Lys Gln Ile Lys Lys Glu Ile Asp Glu Met Leu Ala Asp 
                565                 570                 575     


Thr Asn Leu Arg Ile Glu Arg Leu Lys Ser Asp Lys Arg Ser Val Ala 
            580                 585                 590         


Ser Thr Gln Asn Lys Met Gly Lys Arg Gly Phe Arg Ser Ile Gln Pro 
        595                 600                 605             


Gly Lys Leu Ala Asp Trp Leu Ala Ala Asp Ile Val Lys His Gln Pro 
    610                 615                 620                 


Ser Leu Leu Lys Gly Val Asp Tyr Gly Thr Asp Arg Ile Thr Gly Met 
625                 630                 635                 640 


Asn Tyr Arg Val Met Gln Ser Thr Ile Ala Thr Phe Asn Ala Thr Thr 
                645                 650                 655     


Pro Glu His Ser Leu Glu Glu Leu Lys Lys Val Phe Ser Ala Ala Gln 
            660                 665                 670         


Leu Ile Gln Cys Glu Lys Lys Glu His Pro Phe Leu Tyr Lys Ala Leu 
        675                 680                 685             


Asp Arg Asn Pro Gln Asn Thr Ile Asp Leu Tyr Glu Phe Tyr Leu Ser 
    690                 695                 700                 


Ala Arg Gln Ser Tyr Tyr Lys Ser Met Arg Arg Asn Ile Glu Asn Gly 
705                 710                 715                 720 


Glu Asn Val Lys Leu Pro Tyr Leu Asn Thr Asp Arg Asn Lys Trp Met 
                725                 730                 735     


Arg Arg Gly Ser Val Tyr Tyr Ser Thr Met Gly Glu Ile Tyr Leu Lys 
            740                 745                 750         


Asp Met Pro Ile Glu Leu Pro Arg Gln Met Phe Asp Lys Lys Ile Lys 
        755                 760                 765             


Glu Ala Leu Ala Lys Leu Pro Ser Met Lys Asp Val Asp Met Gln His 
    770                 775                 780                 


Ser Asn Val Thr Phe Leu Ile Ala Glu Tyr Leu Lys Lys Glu Leu Lys 
785                 790                 795                 800 


Asp Asp Phe Gln Pro Phe Tyr Gln Trp Asn Arg Asn Tyr Arg Phe Thr 
                805                 810                 815     


Asp Met Met Ile Cys Glu Glu Asn Arg Ser Thr Arg Ala Leu Ser Thr 
            820                 825                 830         


His Phe Ile Pro Val Ala Leu Arg Glu Glu Ile Trp Glu Lys Arg Ser 
        835                 840                 845             


Glu Leu Lys Ala Ala Tyr Lys Glu Trp Ala Leu Pro Arg Leu Ser Lys 
    850                 855                 860                 


Asn Arg Asp Thr Glu Arg Leu Ser Pro Ala Gln Lys Ser Glu Leu Leu 
865                 870                 875                 880 


Asp Ala Arg Ile Ala Lys Cys Arg Asn Glu Tyr Gln Lys Asn Glu Lys 
                885                 890                 895     


Ile Ile Arg Arg Tyr Lys Val Gln Asp Ala Leu Met Phe Met Met Val 
            900                 905                 910         


Lys Asp Met Phe Gly Lys Gly Val Phe Thr Ala Glu Ser Lys Glu Phe 
        915                 920                 925             


Ala Leu Ser Ala Ile Thr Pro Asp Ala Lys Arg Gly Ile Leu Ser Glu 
    930                 935                 940                 


Val Ile Pro Ile Asp Phe Lys Phe Ser Met Asp Gly Leu Ser Thr Thr 
945                 950                 955                 960 


Ser Glu 
        


<210>  2737
<211>  910
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2737

Leu Tyr Thr Lys Gln Ser Glu Met Glu Ser Gln Pro Lys Arg Thr Asp 
1               5                   10                  15      


Gly Ile Thr Tyr Tyr Asp His Lys Ser Asn Ser Asp Lys His Tyr Phe 
            20                  25                  30          


Gly Gly Tyr Leu Asn Gln Ala Leu Asn Asn Tyr Thr Val Ile Glu Lys 
        35                  40                  45              


Leu Phe Glu Gln Lys Phe Glu Glu Ser Leu Glu Asn Phe Leu Gln Lys 
    50                  55                  60                  


Asn Lys Lys Val Ser Tyr Ala Gln Trp Glu Arg Met Leu Asn Phe Leu 
65                  70                  75                  80  


Lys His His Phe Pro Val Val His Tyr Ile Asp Leu Pro Val Arg Glu 
                85                  90                  95      


Ala Thr Lys Asp Asn Pro Asp Pro Phe Pro Arg Asn Asp Ala Glu Arg 
            100                 105                 110         


Arg Gln His Phe Ile Thr Thr Phe Thr Ser Ile Lys Lys Leu Leu Phe 
        115                 120                 125             


Asp Leu Arg Asn Phe Tyr Ser His Tyr Phe His Glu Pro Ile Asp Thr 
    130                 135                 140                 


Lys Ile Asp Thr Leu Ser His Leu Asp Gln Ile Phe Val Ala Val Cys 
145                 150                 155                 160 


Glu His Val Lys Thr Lys Arg Met Lys Thr Asp Glu Thr Arg Leu Leu 
                165                 170                 175     


Leu Lys Glu Thr Leu Ala Asp Glu Leu Thr His Leu Phe Ile Leu Lys 
            180                 185                 190         


Glu Lys Glu Leu Leu Glu Leu Lys Lys Lys Val Gly Ile Thr Gly Lys 
        195                 200                 205             


Thr Thr Ala Glu Glu Val Arg Asn Ala Ile Phe Asn Asp Ser Phe Lys 
    210                 215                 220                 


His Leu Tyr Tyr Glu Lys Gln Pro Ser Arg Ile Tyr Arg Ser Ser Leu 
225                 230                 235                 240 


Gln Glu Glu Ala Ala Thr Glu Asn Gly Ile Thr Ile Ser Gln Ser Gly 
                245                 250                 255     


Leu Ser Leu Ile Leu Ser Phe Phe Leu Ser Lys Arg Glu Met Glu Gly 
            260                 265                 270         


Phe Lys Ser Arg Leu Arg Gly Leu Lys Gly Arg Val Leu Asn Leu Glu 
        275                 280                 285             


Asn Gly Asn Ile Asp Leu Arg Asn Asn Ser Leu Arg Phe Met Ala Thr 
    290                 295                 300                 


His Trp Val Phe Ser Tyr Leu Cys Phe Lys Gly Pro Asn Gln Lys Leu 
305                 310                 315                 320 


Asn Thr Ser Tyr Leu Glu Glu Thr Leu Leu Val Gln Ile Ile Asp Glu 
                325                 330                 335     


Leu Thr Lys Val Pro His Glu Val Tyr Glu Ala Leu His Val Val Gln 
            340                 345                 350         


Arg Asp Lys Phe Val Glu Asp Ile Asn Glu Phe Met Arg Gln Asp Leu 
        355                 360                 365             


Glu Asp Gly Ser Glu Glu Asn Ala Leu Val Val His Pro Val Ile Arg 
    370                 375                 380                 


Lys Arg Cys Glu Asn Lys Phe Asn Tyr Phe Ala Leu Arg Tyr Leu Asp 
385                 390                 395                 400 


Glu Phe Ala Gly Phe Lys Thr Leu Arg Phe Gln Ile Asn Ile Gly Asn 
                405                 410                 415     


Tyr Ile His Asp Arg Arg Ser Lys Glu Leu Lys Ser Gly Ser Phe Ile 
            420                 425                 430         


Thr Asp Arg Glu Val Lys Glu Arg Ile Asn Val Phe Gly Arg Leu Ser 
        435                 440                 445             


Ala Val Thr Thr Leu Lys Asp Asp Phe Phe Arg Ser Glu Ser Tyr Glu 
    450                 455                 460                 


Gly Ser Ser Trp Glu Arg Phe Pro Asn Pro Ser Tyr Asn Ile Asn Gly 
465                 470                 475                 480 


Asn Asn Ile Ala Ile Tyr Leu Asp Leu Gly Lys Asp His Gly Lys Asp 
                485                 490                 495     


Thr Lys Val Ile Tyr Asp Ala Arg Ser Lys Arg Asn Lys Lys Glu Glu 
            500                 505                 510         


Arg Val Asp Arg Ser Asn Gly Lys Pro Thr Lys Asp Asp Ile Leu Lys 
        515                 520                 525             


Glu Leu Gln Gln Ala Val Glu Val Lys Ser Asp Thr Ile His Arg Lys 
    530                 535                 540                 


Glu Pro Thr Ala Leu Leu Ser Leu His Glu Leu Pro Ala Leu Leu Tyr 
545                 550                 555                 560 


Glu Leu Leu Val Asn His Val Lys Pro Glu Thr Ile Glu Thr Ile Leu 
                565                 570                 575     


Ala Gly Lys Ile Ser Glu Arg Leu Lys Val Ile Gln Glu Tyr Thr Pro 
            580                 585                 590         


Gln Ser Asp Leu Pro Leu Ser Gln Ile Pro Lys Asn Leu Lys Val Ser 
        595                 600                 605             


Gly Gln Glu Pro Lys Val Gln Tyr Asp Lys Leu Ile Arg Leu Ile Asp 
    610                 615                 620                 


Asn Leu Ile Ala Ala Gly Glu Asp Lys Ser Ala Leu Ile Ser Lys Asn 
625                 630                 635                 640 


Gln Arg Glu Ile Ala Asn Pro Lys Ile Lys Arg Asn Phe Val Phe Thr 
                645                 650                 655     


Ile Thr Glu Arg Gly Arg Glu Ala Asn Trp Leu Ala Asn Asp Ile Lys 
            660                 665                 670         


Arg Phe Met Pro Glu Ser Thr Lys Gly Gln Trp Lys Gly Tyr His His 
        675                 680                 685             


Ser Gln Leu Gln Glu Ile Leu Ala Phe Tyr Phe Ala Arg Lys Gln Asp 
    690                 695                 700                 


Ala Ile Ser Leu Leu Asn Ser Val Trp Gln Leu Lys Gln Ser Asp Phe 
705                 710                 715                 720 


Gly Ala Ser Leu Glu Val Leu Phe Leu Lys Pro Gly Phe Asp Ser Phe 
                725                 730                 735     


Tyr Ile Ala Tyr Leu Gln Asn Arg Lys Glu His Leu Gly Gln Ile Arg 
            740                 745                 750         


Asp Arg Ile Leu Gln Tyr Gln Ser Glu Lys Asn Val Ile Lys Lys Val 
        755                 760                 765             


Leu Lys Ser Ile Asp His Ile Phe Pro Lys Lys Val Tyr Thr Ile Arg 
    770                 775                 780                 


Ser Thr Gln Asp Gln Ile Glu Asn Leu Leu Gly Lys Pro Ile Ala Phe 
785                 790                 795                 800 


Ser Arg Gly Ile Phe Asp Ser Lys Pro Thr Phe Ile Thr Asp Thr Thr 
                805                 810                 815     


Phe Glu Gly Asn Glu His Leu Phe Ala Asp Trp Tyr Arg Thr Ser Arg 
            820                 825                 830         


Asp Lys Ser Ile Ala Phe Gln Ser Phe Tyr Asn Leu Pro Lys Asp Tyr 
        835                 840                 845             


Ser Glu Leu Ile Ser His Ala Lys Glu Thr Gly Lys Arg Ile His Asp 
    850                 855                 860                 


Leu Ser Ala Arg Val Lys Met Asn Thr Asp Leu Asn Ile Lys Asn Val 
865                 870                 875                 880 


Gln Ile Lys Asp Phe Phe Leu Lys Lys Ile Ala Asp Ala Leu Phe Gln 
                885                 890                 895     


Lys Cys Leu Gly Gln Thr Phe Ala Asn Ser Glu Gly Asn Asp 
            900                 905                 910 


<210>  2738
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2738

Met Thr Glu Gln Asn Glu Lys Pro Tyr Asn Gly Thr Tyr Tyr Thr Leu 
1               5                   10                  15      


Glu Asp Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Ala Tyr Ile Thr Leu Ala His Ile Asp Arg Gln Leu Ala Tyr Ser Lys 
        35                  40                  45              


Ala Asp Ile Thr Asn Asp Glu Asp Ile Leu Phe Phe Lys Gly Gln Trp 
    50                  55                  60                  


Lys Asn Leu Asp Asn Asp Leu Glu Arg Lys Ala Arg Leu Arg Ser Leu 
65                  70                  75                  80  


Ile Leu Lys His Phe Ser Phe Leu Glu Gly Ala Ala Tyr Gly Lys Lys 
                85                  90                  95      


Leu Phe Glu Ser Gln Ser Ser Gly Asn Lys Ser Ser Lys Lys Lys Glu 
            100                 105                 110         


Leu Thr Lys Lys Glu Lys Glu Glu Leu Gln Ala Asn Ala Leu Ser Leu 
        115                 120                 125             


Asp Asn Leu Lys Ser Ile Leu Phe Asp Phe Leu Gln Lys Leu Lys Asp 
    130                 135                 140                 


Phe Arg Asn Tyr Tyr Ser His Tyr Arg His Pro Glu Ser Ser Glu Leu 
145                 150                 155                 160 


Pro Leu Phe Asp Gly Asn Met Leu Gln Arg Leu Tyr Asn Val Phe Asp 
                165                 170                 175     


Val Ser Val Gln Arg Val Lys Arg Asp His Glu His Asn Asp Lys Val 
            180                 185                 190         


Asp Pro His Arg His Phe Asn His Leu Val Arg Lys Gly Lys Lys Asp 
        195                 200                 205             


Arg Cys Gly Asn Asn Asp Asn Pro Phe Phe Lys His His Phe Val Asp 
    210                 215                 220                 


Arg Glu Gly Thr Val Thr Glu Ala Gly Leu Leu Phe Phe Val Ser Leu 
225                 230                 235                 240 


Phe Leu Glu Lys Arg Asp Ala Ile Trp Met Gln Lys Lys Ile Arg Gly 
                245                 250                 255     


Phe Lys Gly Gly Thr Glu Ala Tyr Gln Gln Met Thr Asn Glu Val Phe 
            260                 265                 270         


Cys Arg Ser Arg Ile Ser Leu Pro Lys Leu Lys Leu Glu Ser Leu Arg 
        275                 280                 285             


Thr Asp Asp Trp Met Leu Leu Asp Met Leu Asn Glu Leu Val Arg Cys 
    290                 295                 300                 


Pro Lys Ser Leu Tyr Asp Arg Leu Arg Glu Glu Asp Arg Ala Arg Phe 
305                 310                 315                 320 


Arg Val Pro Val Asp Ile Leu Ser Asp Glu Asp Asp Thr Asp Gly Ala 
                325                 330                 335     


Glu Glu Asp Pro Phe Lys Asn Thr Leu Val Arg His Gln Asp Arg Phe 
            340                 345                 350         


Pro Tyr Phe Ala Leu Arg Tyr Phe Asp Leu Lys Lys Val Phe Thr Ser 
        355                 360                 365             


Leu Arg Phe His Ile Asp Leu Gly Thr Tyr His Phe Ala Ile Tyr Lys 
    370                 375                 380                 


Lys Asn Ile Gly Glu Gln Pro Glu Asp Arg His Leu Thr Arg Asn Leu 
385                 390                 395                 400 


Tyr Gly Phe Gly Arg Ile Gln Asp Phe Ala Glu Glu His Arg Pro Glu 
                405                 410                 415     


Glu Trp Lys Arg Leu Val Arg Asp Leu Asp Tyr Phe Glu Thr Gly Asp 
            420                 425                 430         


Lys Pro Tyr Ile Thr Gln Thr Thr Pro His Tyr His Ile Glu Lys Gly 
        435                 440                 445             


Lys Ile Gly Leu Arg Phe Val Pro Glu Gly Gln His Leu Trp Pro Ser 
    450                 455                 460                 


Pro Glu Val Gly Ala Thr Arg Thr Gly Arg Ser Lys Tyr Ala Gln Asp 
465                 470                 475                 480 


Lys Arg Phe Thr Ala Glu Ala Phe Leu Ser Val His Glu Leu Met Pro 
                485                 490                 495     


Met Met Phe Tyr Tyr Phe Leu Leu Arg Glu Lys Tyr Ser Glu Glu Val 
            500                 505                 510         


Ser Ala Glu Lys Val Gln Gly Arg Ile Lys Arg Val Ile Glu Asp Val 
        515                 520                 525             


Tyr Ala Val Tyr Asp Ala Phe Ala Arg Asp Glu Ile Asn Thr Arg Asp 
    530                 535                 540                 


Glu Leu Asp Ala Cys Leu Ala Asp Lys Gly Ile Arg Arg Gly His Leu 
545                 550                 555                 560 


Pro Arg Gln Met Ile Ala Ile Leu Ser Gln Glu His Lys Asp Met Glu 
                565                 570                 575     


Glu Lys Val Arg Lys Lys Leu Gln Glu Met Ile Ala Asp Thr Asp His 
            580                 585                 590         


Arg Leu Asp Met Leu Asp Arg Gln Thr Asp Arg Lys Ile Arg Ile Gly 
        595                 600                 605             


Arg Lys Asn Ala Gly Leu Pro Lys Ser Gly Val Ile Ala Asp Trp Leu 
    610                 615                 620                 


Val Arg Asp Met Met Arg Phe Gln Pro Val Ala Lys Asp Thr Ser Gly 
625                 630                 635                 640 


Lys Pro Leu Asn Asn Ser Lys Ala Asn Ser Thr Glu Tyr Arg Met Leu 
                645                 650                 655     


Gln Arg Ala Leu Ala Leu Phe Gly Gly Glu Lys Glu Arg Leu Thr Pro 
            660                 665                 670         


Tyr Phe Arg Gln Met Asn Leu Thr Gly Gly Asn Asn Pro His Pro Phe 
        675                 680                 685             


Leu His Glu Thr Arg Trp Glu Ser His Thr Asn Ile Leu Ser Phe Tyr 
    690                 695                 700                 


Arg Ser Tyr Leu Lys Ala Arg Lys Ala Phe Leu Gln Ser Ile Gly Arg 
705                 710                 715                 720 


Ser Asp Arg Val Glu Asn His Arg Phe Leu Leu Leu Lys Glu Pro Lys 
                725                 730                 735     


Thr Asp Arg Gln Thr Leu Val Ala Gly Trp Lys Gly Glu Phe His Leu 
            740                 745                 750         


Pro Arg Gly Ile Phe Thr Glu Ala Val Arg Asp Cys Leu Ile Glu Met 
        755                 760                 765             


Gly Tyr Asp Glu Val Gly Ser Tyr Lys Glu Val Gly Phe Met Ala Lys 
    770                 775                 780                 


Ala Val Pro Leu Tyr Phe Glu Arg Ala Cys Lys Asp Arg Val Gln Pro 
785                 790                 795                 800 


Phe Tyr Asp Tyr Pro Phe Asn Val Gly Asn Ser Leu Lys Pro Lys Lys 
                805                 810                 815     


Gly Arg Phe Leu Ser Lys Glu Lys Arg Ala Glu Glu Trp Glu Ser Gly 
            820                 825                 830         


Lys Glu Arg Phe Arg Asp Leu Glu Ala Trp Ser Gln Ser Thr Ala Arg 
        835                 840                 845             


Arg Ile Glu Asp Ala Phe Ala Gly Ile Lys Tyr Ala Ser Trp Glu Asn 
    850                 855                 860                 


Lys Lys Lys Ile Glu Gln Leu Leu Gln Asp Leu Ser Leu Trp Glu Ala 
865                 870                 875                 880 


Phe Glu Ser Lys Leu Lys Val Lys Ala Asp Lys Ile Asn Ile Ala Lys 
                885                 890                 895     


Leu Lys Lys Glu Ile Leu Glu Ala Lys Glu His Pro Tyr Leu Asp Phe 
            900                 905                 910         


Lys Ser Trp Gln Lys Phe Glu Arg Glu Leu 
        915                 920         


<210>  2739
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2739

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2740
<211>  1146
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2740

Met Glu Ser Ile Ile Gly Leu Gly Leu Ser Phe Asn Pro Tyr Lys Thr 
1               5                   10                  15      


Ala Asp Lys His Tyr Phe Gly Ser Phe Leu Asn Leu Ala Asp Asn Asn 
            20                  25                  30          


Leu Lys Ala Val Phe Ala Glu Phe Lys Glu Arg Ile Ser Asp Lys Ser 
        35                  40                  45              


Lys Asp Glu Asp Ile Ser Asn Leu Ile Glu Lys His Phe Ile Asp Asn 
    50                  55                  60                  


Met Ser Ile Val Asp Tyr Glu Lys Asn Ile Ser Ile Leu Asn Gly Tyr 
65                  70                  75                  80  


Leu Pro Ile Ile Asp Phe Leu Asp Asp Glu Leu Glu Asn Asn Leu Asn 
                85                  90                  95      


Thr Arg Val Lys Asn Phe Lys Lys Ser Phe Ile Ile Leu Ala Glu Ala 
            100                 105                 110         


Leu Glu Thr Leu Arg Asn Tyr Tyr Thr His Phe Tyr His Asp Pro Ile 
        115                 120                 125             


Thr Phe Gly Asp Asn Lys Glu Pro Leu Leu Glu Leu Leu Asp Glu Val 
    130                 135                 140                 


Leu Leu Lys Thr Ile Leu Asp Val Lys Lys Lys Tyr Leu Lys Thr Asp 
145                 150                 155                 160 


Lys Thr Lys Glu Ile Leu Lys Asp Ser Leu Arg Glu Glu Met Asp Leu 
                165                 170                 175     


Leu Val Ile Arg Lys Thr Asp Glu Leu Arg Glu Lys Lys Lys Thr Asn 
            180                 185                 190         


Pro Lys Phe Lys Phe Ser Thr Asp Pro Thr Gln Ile Arg Asn Ser Ile 
        195                 200                 205             


Phe Asn Asp Ala Phe Gln Gly Leu Leu Tyr Glu Asp Lys Glu Asn Asn 
    210                 215                 220                 


Gly Lys Thr Gln Val Ser Tyr Arg Ala Lys Thr Lys Leu Asn Pro Lys 
225                 230                 235                 240 


Asp Ile His Lys Gln Glu Glu Arg Asp Phe Glu Ile Pro Leu Ser Thr 
                245                 250                 255     


Ser Gly Ile Val Phe Leu Met Ser Leu Phe Leu Ser Lys Lys Glu Ile 
            260                 265                 270         


Glu Asp Phe Lys Ser Asn Ile Lys Gly Phe Lys Gly Lys Val Val Lys 
        275                 280                 285             


Asp Glu Asn His Asn Ser Leu Lys Tyr Met Ala Thr His Arg Val Tyr 
    290                 295                 300                 


Ser Ile Leu Ala Phe Lys Gly Leu Lys Tyr Arg Ile Lys Thr Asp Thr 
305                 310                 315                 320 


Phe Ser Lys Val Thr Leu Met Met Gln Met Ile Asp Glu Leu Ser Lys 
                325                 330                 335     


Val Pro Asp Cys Val Tyr Gln Asn Leu Ser Glu Thr Lys Gln Lys Asp 
            340                 345                 350         


Phe Ile Glu Asp Trp Asn Glu Tyr Leu Lys Asp Asn Glu Glu Asn Thr 
        355                 360                 365             


Glu Asn Leu Glu Asn Ser Arg Val Val His Pro Leu Ile Arg Lys Arg 
    370                 375                 380                 


Tyr Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe 
385                 390                 395                 400 


Ala Asn Phe Lys Thr Leu Lys Phe Gln Val Phe Met Gly Tyr Tyr Ile 
                405                 410                 415     


His Asp Gln Arg Thr Lys Thr Ile Gly Thr Thr Asn Ile Thr Thr Glu 
            420                 425                 430         


Arg Thr Val Lys Glu Lys Ile Asn Val Phe Gly Lys Leu Ser Lys Met 
        435                 440                 445             


Asp Asn Leu Lys Lys His Phe Phe Ser Gln Leu Ser Asp Glu Glu Asn 
    450                 455                 460                 


Thr Asp Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Phe Leu Thr Gln 
465                 470                 475                 480 


Ala Asp Asn Ser Pro Ala Asn Asn Ile Pro Ile Tyr Leu Glu Leu Lys 
                485                 490                 495     


Asn Gln Gln Ile Ile Lys Glu Lys Asp Asp Ile Lys Ala Glu Val Asn 
            500                 505                 510         


Asn Ser Gln Asn Arg Asn Pro Asn Lys Pro Ser Lys Arg Asp Leu Leu 
        515                 520                 525             


Asn Lys Ile Ser Asn Thr Asn Glu Asp Phe Tyr Gln Gly Asp Pro Thr 
    530                 535                 540                 


Ala Ile Leu Ser Leu Asn Glu Ile Pro Ala Leu Leu His Leu Phe Leu 
545                 550                 555                 560 


Val Gln Pro Asp Asn Lys Thr Gly Gln Gln Ile Glu Asn Ile Ile Arg 
                565                 570                 575     


Ile Lys Ile Glu Lys Gln Phe Asn Ser Ile Lys Asn Pro Ser Lys Asp 
            580                 585                 590         


Asp Lys Gly Val Pro Lys Ser Leu Phe Ala Asp Thr Asn Val Arg Val 
        595                 600                 605             


Asn Ala Ile Lys Leu Lys Lys Asp Leu Gly Glu Glu Leu Asp Met Leu 
    610                 615                 620                 


Asn Lys Lys Gln Ile Val Phe Lys Glu Asn Gln Lys Ala Ser Ser Asn 
625                 630                 635                 640 


Tyr Asp Glu Leu Leu Lys Lys His Gln Phe Thr Pro Lys Asn Lys Arg 
                645                 650                 655     


Pro Ala Leu Arg Lys Tyr Val Phe Tyr Asn Ser Glu Lys Gly Glu Glu 
            660                 665                 670         


Ala Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Lys Gly Phe 
        675                 680                 685             


Lys Thr Lys Trp Lys Gly Tyr Gln His Ser Glu Leu Gln Arg Lys Leu 
    690                 695                 700                 


Ala Phe Tyr Asp Arg His Thr Lys Gln Asp Ile Lys Glu Leu Leu Ser 
705                 710                 715                 720 


Gly Cys Glu Phe Asp His Phe Leu Leu Asp Ile Asn Ala Cys Phe Lys 
                725                 730                 735     


Glu Asp Asp Phe Glu Asp Phe Phe Ser Lys Tyr Leu Lys Asn Arg Ile 
            740                 745                 750         


Glu Thr Leu Asn Ile Ile Leu Lys Gln Leu His Asp Phe Lys Asn Glu 
        755                 760                 765             


Pro Thr Pro Leu Lys Gly Val Phe Lys Asn Cys Leu Lys Phe Leu Lys 
    770                 775                 780                 


Gln Lys Asn Tyr Val Thr Glu Asn Pro Glu Ile Ile Lys Lys Arg Ile 
785                 790                 795                 800 


Leu Ala Lys Pro Ala Phe Leu Pro Arg Gly Ile Phe Asp Glu Arg Pro 
                805                 810                 815     


Thr Met Lys Lys Gly Lys Asn Pro Leu Ile Asp Arg Asp Glu Phe Ala 
            820                 825                 830         


Lys Trp Phe Val Glu Tyr Leu Glu Asn Lys Asp Tyr Gln Lys Phe Tyr 
        835                 840                 845             


Asn Ser Glu Glu Tyr Arg Ile Arg Asp Ala Asp Phe Lys Lys Asn Ala 
    850                 855                 860                 


Val Ile Lys Lys Gln Lys Leu Lys Asp Phe Tyr Thr Leu Gln Met Val 
865                 870                 875                 880 


Asn Tyr Leu Leu Lys Glu Val Phe Gly Lys Asp Glu Met Asn Leu Gln 
                885                 890                 895     


Leu Ser Glu Leu Phe Gln Thr Arg Gln Glu Arg Leu Lys Leu Gln Gly 
            900                 905                 910         


Ile Ala Lys Lys Gln Met Asn Lys Glu Thr Gly Asp Ser Ser Glu Asn 
        915                 920                 925             


Thr Arg Asn Gln Thr Tyr Ile Trp Asn Lys Asp Val Pro Val Ser Phe 
    930                 935                 940                 


Phe Asn Gly Lys Val Thr Ile Asp Lys Val Lys Leu Lys Asn Ile Gly 
945                 950                 955                 960 


Lys Tyr Lys Arg Tyr Glu Arg Asp Glu Arg Val Lys Thr Phe Ile Gly 
                965                 970                 975     


Tyr Glu Val Asp Glu Lys Trp Met Met Tyr Leu Pro His Asn Trp Lys 
            980                 985                 990         


Asp Arg Tyr Ser Val Lys Pro Ile  Asn Val Ile Asp Leu  Gln Ile Gln 
        995                 1000                 1005             


Glu Tyr  Glu Glu Ile Arg Ser  His Glu Leu Leu Lys  Glu Ile Gln 
    1010                 1015                 1020             


Asn Leu  Glu Gln Tyr Ile Tyr  Asp His Thr Thr Asp  Lys Asn Thr 
    1025                 1030                 1035             


Leu Leu  Gln Asp Gly Asn Pro  Asn Phe Lys Met Tyr  Val Leu Asn 
    1040                 1045                 1050             


Gly Leu  Leu Thr Gly Ile Lys  Gln Val Asn Ile Ala  Asp Phe Ile 
    1055                 1060                 1065             


Val Leu  Lys Gln Asn Thr Asn  Phe Asp Lys Ile Asp  Phe Thr Gly 
    1070                 1075                 1080             


Ile Ala  Ser Cys Ser Glu Leu  Glu Lys Lys Thr Ile  Ile Leu Ile 
    1085                 1090                 1095             


Ala Ile  Arg Asn Lys Phe Ala  His Asn Gln Leu Pro  Asn Lys Thr 
    1100                 1105                 1110             


Ile Tyr  Asp Leu Ala Asn Glu  Phe Leu Lys Lys Glu  Lys Arg Glu 
    1115                 1120                 1125             


Thr Tyr  Ala Asn Tyr Tyr Leu  Lys Val Leu Lys Lys  Met Ile Ser 
    1130                 1135                 1140             


Asp Leu  Ala 
    1145     


<210>  2741
<211>  1131
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2741

Met Glu Lys Thr Ile Glu Asn Gln Thr Gln Ser Lys Arg Thr Leu Asn 
1               5                   10                  15      


Asn Thr Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Asp Glu Glu Lys Ile Thr Thr Ser Phe Leu Val Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Arg Gln Ser Leu Val Tyr Ser Asn Leu Thr 
65                  70                  75                  80  


Arg Tyr Met His Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Asp 
                85                  90                  95      


Asp Glu Arg Asp Lys Ala Glu Asn Tyr Gly Lys Asp Phe Gly Asn Leu 
            100                 105                 110         


Thr Asp Thr Leu Lys Glu Ile Phe Lys Glu Leu Asn Glu Phe Arg Asn 
        115                 120                 125             


Asp Tyr Ser His Tyr Tyr Ser Thr Glu Lys Lys Asp Lys Arg Lys Thr 
    130                 135                 140                 


Ile Val Ser Asp Lys Leu Lys Asn Phe Leu Asn Ile Asn Tyr Thr Arg 
145                 150                 155                 160 


Ala Ile Lys Tyr Thr Lys Ser Arg Phe Ile Asn Val Phe Ser Asp Asn 
                165                 170                 175     


Asn Phe Cys Leu Ala Glu Glu Ala Lys His Val Glu Asn Asp Asn Thr 
            180                 185                 190         


Ile Thr Gln Asp Gly Ile Val Phe Phe Thr Ser Met Phe Leu Asp Arg 
        195                 200                 205             


Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile Ile Gly Leu Lys Gly Thr 
    210                 215                 220                 


Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Thr Leu Met Ala Phe Cys 
225                 230                 235                 240 


Val Asn Leu Pro His Asp Lys Phe Val Ser Glu Asn Ser Glu Gln Gln 
                245                 250                 255     


Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu 
            260                 265                 270         


Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln His Phe Leu Pro Lys Leu 
        275                 280                 285             


Asp Asp Glu Gln Ile Asp Asn Val Leu Glu Asn Ser Val Pro Tyr Thr 
    290                 295                 300                 


Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn Ile Thr Lys Lys Val Arg 
305                 310                 315                 320 


Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu Lys Phe Ile Asp Gln Lys 
                325                 330                 335     


Lys Leu Phe Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val 
            340                 345                 350         


Leu Asp Glu Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Lys Arg Thr 
        355                 360                 365             


Val Thr Glu Asn Thr Lys Ala Phe Gly Met Leu Gln Asp Leu Asn Asp 
    370                 375                 380                 


Glu Glu Asn Val Leu Asn Lys Ile Asn Thr Gly Glu Ser Lys Ala Lys 
385                 390                 395                 400 


Phe Asp Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Thr Lys Asn 
            420                 425                 430         


Thr Asp Asn Lys Ile Lys Ser Asn Leu Leu Gln Pro Leu Pro Glu Ala 
        435                 440                 445             


Phe Leu Ser Ile Asn Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
    450                 455                 460                 


Glu Gln Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn 
465                 470                 475                 480 


Asn Ser Lys Ile Leu Asn Lys Glu Phe Ile Lys Ala Ile Lys Leu Lys 
                485                 490                 495     


Leu Asn Asp Leu Asp Val Phe Tyr Lys Arg Ser Gln Gly Arg Lys Gln 
            500                 505                 510         


Lys His Ala Tyr Leu Thr Lys Asp Lys Lys Tyr Asp Asn Glu Lys Ile 
        515                 520                 525             


Asn Glu Leu Lys Asn Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu 
    530                 535                 540                 


Tyr Asn Leu Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp 
545                 550                 555                 560 


Leu Asn Ile Ala Asp Val Gln Ala Lys Asn Ala Ile Ser Asp Arg Ile 
                565                 570                 575     


Lys Leu Met Lys Arg Asp Cys Ile Asn Arg Leu Lys Ser Met Lys Lys 
            580                 585                 590         


Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp 
        595                 600                 605             


Ile Val Asp Met Ile Ile Asp Glu Glu Lys Lys Lys Lys Ile Thr Ser 
    610                 615                 620                 


Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Lys 
625                 630                 635                 640 


Glu Lys Lys Glu Leu Phe Ile Leu Ile Cys Asn Asn Glu Leu Lys Leu 
                645                 650                 655     


Asn Asp Asp Asp Gly His Pro Phe Phe Lys Asn Ile Asn Phe Ser Asn 
            660                 665                 670         


Tyr Lys Tyr Thr Ser Glu Ile Tyr Gln Lys Tyr Leu Glu Glu Lys Gly 
        675                 680                 685             


His Lys Met Val Lys Glu Tyr Asn Pro Arg Lys Glu Asn Tyr Val Glu 
    690                 695                 700                 


Lys Asp Lys Ser Trp Leu Glu Ile Asn Phe Tyr Lys Lys Glu Trp Asn 
705                 710                 715                 720 


Glu Asn Ala Lys Lys Asp Leu Thr Val Val Lys Leu Pro Asp Asp Lys 
                725                 730                 735     


Ser Lys Ile Pro Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser 
            740                 745                 750         


Phe Glu Asn Trp Phe Lys Tyr Val Thr Asn Gly Lys Glu Thr Thr Asp 
        755                 760                 765             


Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp Glu Thr Leu 
    770                 775                 780                 


Lys Glu Leu Leu Lys Lys Glu Leu Ser Lys Asn Asn Ile Glu Phe Lys 
785                 790                 795                 800 


Glu Glu Asp Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Asp Lys Cys 
                805                 810                 815     


Arg Asn Asp Lys Thr Gln Lys Phe Tyr Ser Ala Glu Arg Glu Tyr Thr 
            820                 825                 830         


Phe Glu Glu Glu Lys Leu Asn Phe His Ile Asn Thr Lys Ser Lys Phe 
        835                 840                 845             


Glu Glu Tyr Ile Asn Pro Glu Phe Ala Glu Lys Val Phe Arg Leu Lys 
    850                 855                 860                 


Asn Gln Asn Arg Glu Lys Asp Asn Ile Ser Gly Arg Arg Leu Pro Pro 
865                 870                 875                 880 


Leu Lys Met Lys Glu Val Thr Lys Asn Met Val Lys Arg Ile Gly Asn 
                885                 890                 895     


Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Leu Met Leu 
            900                 905                 910         


Leu Met Phe Glu Lys Leu Val Asp Asn Asn Leu Lys Leu Lys Leu Glu 
        915                 920                 925             


Asn Val Asp Lys Leu Leu Asn Glu Ser Ile Glu Ile Asn Gln Ser Ile 
    930                 935                 940                 


Ser Gly Lys Leu Ser Phe Asp Asp Ser Gly Asp Asn Glu Asn Lys Lys 
945                 950                 955                 960 


Asp Arg Ala Ile Ile Cys Arg Asn Ile Thr Glu Thr Arg Lys Arg Lys 
                965                 970                 975     


Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Glu Glu Glu  Asn Ile Pro Ile Glu  Lys Ile Lys 
        995                 1000                 1005             


Ile Glu  Leu Asp Thr Tyr Ser  Lys Ala Lys Asp Val  Val Phe Asp 
    1010                 1015                 1020             


Leu Ile  Phe Asp Leu Glu Arg  Ala Ile Ile Asn Lys  Asp Glu Asn 
    1025                 1030                 1035             


Arg Ile  Lys Glu Leu Asn Lys  Asp Lys Asn Gly Val  Ile Gln Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Phe Trp Leu  Leu Glu Lys 
    1055                 1060                 1065             


Asn Leu  Ile Thr Glu Gln Glu  Phe Thr Phe Met Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Thr  Phe Ser His Asn Gln  Phe Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Leu Phe  Ile Lys Asn Trp Asn  Glu Asn Glu Phe Ala  Lys Gln Ile 
    1100                 1105                 1110             


Leu Asn  Val Tyr Asn Gln Lys  Asn Asn Asn Leu Ile  Lys Ser Ile 
    1115                 1120                 1125             


Lys Asp  Ile 
    1130     


<210>  2742
<211>  930
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2742

Val Lys Met Lys Glu Lys Glu Thr Pro Val Ala Ser Thr Val Asn Lys 
1               5                   10                  15      


Asp Glu Lys His Phe Trp Ala Ala Phe Leu Asn Leu Ala Arg His Asn 
            20                  25                  30          


Val Tyr Ile Thr Ile Asn His Ile Asn Lys Leu Leu Glu Ile Arg Glu 
        35                  40                  45              


Ile Asp Asn Asp Glu Lys Val Leu Asp Ile Lys Thr Leu Trp Gln Lys 
    50                  55                  60                  


Val Asn Lys Asp Leu Asn Gln Lys Ala Arg Leu Arg Glu Leu Met Thr 
65                  70                  75                  80  


Lys His Phe Pro Phe Leu Glu Thr Ala Ile Tyr Ser Lys Asn Lys Glu 
                85                  90                  95      


Asp Lys Glu Glu Val Lys Gln Glu Lys Gln Ala Thr Ala Gln Ser Phe 
            100                 105                 110         


Lys Ser Leu Glu His Cys Leu Phe Leu Phe Leu Glu Lys Leu Gln Glu 
        115                 120                 125             


Ala Arg Asn Tyr Tyr Ser His Tyr Lys Tyr Ser Glu Ser Thr Lys Glu 
    130                 135                 140                 


Pro Met Leu Glu Lys Glu Leu Leu Lys Lys Met Tyr Asn Ile Phe Asp 
145                 150                 155                 160 


Asn Asn Ile Gln Leu Val Ile Lys Asp Tyr Gln His Asn Lys Asp Ile 
                165                 170                 175     


Asn Pro Asp Glu Asp Phe Lys His Leu Asp Arg Thr Glu Lys Glu Phe 
            180                 185                 190         


Asn Tyr Tyr Phe Thr Gln Asp Lys Lys Gly Lys Ile Thr Glu Ser Gly 
        195                 200                 205             


Leu Leu Phe Phe Val Ser Leu Phe Leu Glu Lys Lys Asp Ala Ile Trp 
    210                 215                 220                 


Met Gln Gln Lys Phe Thr Gly Phe Lys Asp Asn Arg Glu Asn Asn Lys 
225                 230                 235                 240 


Gln Met Thr His Glu Val Phe Cys Arg Ser Arg Met Leu Leu Pro Lys 
                245                 250                 255     


Leu Arg Leu Glu Ser Thr Gln Thr Gln Asp Trp Ile Leu Leu Asp Met 
            260                 265                 270         


Leu Asn Glu Leu Ile Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Lys 
        275                 280                 285             


Gly Glu Asp Arg Lys Lys Phe Glu Val Pro Phe Asp Ser Thr Asp Glu 
    290                 295                 300                 


Asp Tyr Asp Ala Glu Gln Asp Pro Phe Lys Asn Thr Leu Ile Arg His 
305                 310                 315                 320 


Gln Asp Arg Phe Pro Tyr Phe Ile Leu Arg Tyr Phe Asp Tyr Asn Glu 
                325                 330                 335     


Ile Phe Lys Asn Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe 
            340                 345                 350         


Ser Ile Tyr Lys Lys Leu Ile Gly Gly Gln Lys Glu Tyr Arg His Leu 
        355                 360                 365             


Thr His Lys Leu Tyr Gly Phe Glu Arg Ile Gln Glu Phe Thr Lys Gln 
    370                 375                 380                 


His Arg Pro Asp Asp Trp Lys Ala Ile Val Lys Asp Phe Asp Thr Tyr 
385                 390                 395                 400 


Glu Thr Ser Glu Glu Pro Tyr Ile Ser Glu Thr Thr Pro His Tyr His 
                405                 410                 415     


Leu Glu Asn Gln Lys Ile Gly Ile Arg Phe Lys Asn Asp Asn Asp Lys 
            420                 425                 430         


Ile Trp Pro Ser Leu Glu Thr Asn Gly Glu Asn Asn Glu Lys Ser Lys 
        435                 440                 445             


Tyr Lys Leu Asp Lys Gln Tyr Gln Ala Glu Ala Phe Leu Ser Val His 
    450                 455                 460                 


Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Lys Lys Glu Glu 
465                 470                 475                 480 


Pro Asn Asn Asp Lys Lys Asn Ala Ser Arg Val Glu Gly Phe Ile Lys 
                485                 490                 495     


Arg Glu Ile Arg Asp Ile Phe Lys Leu Tyr Asp Ala Phe Ala Asn Asp 
            500                 505                 510         


Glu Ile Asn Asn Ile Asp Asp Leu Lys Lys Tyr Tyr Lys Asp Lys Asn 
        515                 520                 525             


Val Glu Ile Arg His Leu Pro Lys Gln Met Ile Ala Ile Leu Glu Ser 
    530                 535                 540                 


Lys Pro Lys Asp Met Ala Lys Glu Ala Lys Arg Lys Gln Lys Glu Met 
545                 550                 555                 560 


Val Lys Asp Thr Lys Lys Leu Leu Ala Thr Leu Glu Lys Gln Thr Gln 
                565                 570                 575     


Lys Glu Lys Glu Asp Glu Gly Arg Asn Val Lys Leu Leu Lys Ser Gly 
            580                 585                 590         


Glu Ile Ala Arg Trp Leu Val Asn Asp Met Met Arg Phe Gln Pro Val 
        595                 600                 605             


Gln Lys Asp Asn Glu Gly Asn Pro Leu Asn Asn Ser Lys Ala Asn Ser 
    610                 615                 620                 


Thr Glu Tyr Gln Met Leu Gln Arg Ser Leu Ala Leu Tyr Asn Lys Glu 
625                 630                 635                 640 


Glu Lys Pro Thr Arg Tyr Phe Arg Gln Val Asn Leu Ile Glu Ser Ser 
                645                 650                 655     


Asn Pro His Pro Phe Leu Lys Trp Thr Lys Trp Glu Glu Cys Asn Asn 
            660                 665                 670         


Ile Leu Thr Phe Tyr His Arg Tyr Leu Thr Lys Lys Ile Glu Phe Leu 
        675                 680                 685             


Asn Lys Leu Lys Pro Glu Asp Trp Lys Lys Asn Gln Tyr Phe Leu Lys 
    690                 695                 700                 


Val Lys Glu Pro Lys Thr Asn Arg Glu Thr Leu Val Gln Gly Trp Lys 
705                 710                 715                 720 


Asn Gly Phe Asn Leu Pro Arg Gly Ile Phe Thr Glu Pro Ile Arg Glu 
                725                 730                 735     


Trp Phe Glu Arg His Gln Asn Asp Ser Glu Glu Tyr Lys Lys Val Glu 
            740                 745                 750         


Lys Leu Asn Lys Ala Gly Leu Val Thr Lys Val Ile Pro Leu Phe Phe 
        755                 760                 765             


Lys Glu Glu Pro Phe Lys Glu Asp Thr Lys Lys Glu Ile Asn Asp Trp 
    770                 775                 780                 


Val Gln Pro Phe Tyr Ser Phe Pro Tyr Asn Val Gly Asn Ile His Lys 
785                 790                 795                 800 


Pro Lys Glu Glu Asp Phe Leu His Arg Glu Glu Arg Ile Glu Leu Trp 
                805                 810                 815     


Asp Lys Lys Lys Asp Lys Phe Lys Gly Tyr Lys Glu Lys Ile Lys Ser 
            820                 825                 830         


Lys Lys Leu Thr Glu Lys Glu Lys Glu Glu Phe Arg Ser Tyr Leu Glu 
        835                 840                 845             


Phe Gln Ser Trp Asn Lys Phe Glu Arg Glu Leu Arg Leu Val Arg Asn 
    850                 855                 860                 


Gln Asp Ile Val Thr Trp Leu Leu Cys Lys Glu Leu Ile Asp Lys Leu 
865                 870                 875                 880 


Lys Ile Asp Glu Leu Asn Ile Glu Glu Leu Lys Lys Leu Arg Leu Lys 
                885                 890                 895     


Asp Ile Asp Thr Asp Thr Ala Lys Gln Glu Lys Asn Asn Ile Leu Asn 
            900                 905                 910         


Arg Val Met Pro Met Gln Leu Pro Val Thr Val Tyr Glu Ile Asp Asp 
        915                 920                 925             


Ser His 
    930 


<210>  2743
<211>  1116
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2743

Met Glu Asn Thr Ile Glu Ile Gln Lys Gln Ser Ile Arg Thr Leu Asn 
1               5                   10                  15      


Asn Ala Pro Gln Tyr Phe Gly Leu Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn Tyr Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Glu Glu Glu Lys Ile Thr Ile Ser Phe Leu Gly Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Lys Gln Ser Tyr Ile Tyr Phe Asn Leu Ile 
65                  70                  75                  80  


Lys Tyr Met Pro Val Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Lys 
                85                  90                  95      


Asn Glu Ile Asp Lys Thr Lys Asn Asn Ser Gly Lys Asp Phe Asn Lys 
            100                 105                 110         


Leu Ser Asp Thr Leu Lys Val Ile Phe Lys Glu Leu Asn Glu Phe Arg 
        115                 120                 125             


Asn Asp Tyr Ser His Tyr Phe Ser Thr Glu Lys Gln Asp Lys Arg Lys 
    130                 135                 140                 


Leu Lys Ile Ser Ser Glu Leu Lys Asp Phe Leu Asn Ile Asn Phe Ser 
145                 150                 155                 160 


Arg Ala Leu Ser Tyr Thr Lys Asn Arg Leu Lys Asp Val Phe Ser Asp 
                165                 170                 175     


Asp Asp Phe Asn Ile Ala Ser Gln Thr Val Val Val Asn Asn Asp Asn 
            180                 185                 190         


Thr Ile Thr Gln Asp Gly Ile Val Phe Leu Ile Ser Met Phe Leu Asp 
        195                 200                 205             


Met Glu Asn Ala Phe Gln Phe Ile Asn Lys Ile Ile Gly Leu Lys Gly 
    210                 215                 220                 


Thr Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Val Leu Met Thr Phe 
225                 230                 235                 240 


Cys Val Lys Leu Pro His Asp Lys Phe Val Ser Glu Asn Pro Gln Gln 
                245                 250                 255     


Thr Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Leu 
            260                 265                 270         


Leu Tyr Asn Val Ile Thr Glu Glu Glu Lys Gln Ile Phe Lys Pro Gln 
        275                 280                 285             


Ile Gln Thr Glu Gln Ile Glu Asn Ile Ile Ser Asn Ser Val Pro Asp 
    290                 295                 300                 


Thr Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Ser Ile Thr Lys Lys Val 
305                 310                 315                 320 


Arg Tyr Glu Asn Arg Phe Ser Tyr Phe Ala Leu Lys Tyr Ile Asp Leu 
                325                 330                 335     


Lys Glu Leu Phe Lys Lys Trp Arg Phe Gln Ile Asp Leu Gly Lys Val 
            340                 345                 350         


Val Leu Asp Lys Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Val Arg 
        355                 360                 365             


Thr Val Thr Glu Asn Ala Lys Ala Phe Gly Arg Leu Gln Asp Phe Tyr 
    370                 375                 380                 


Asp Gln Glu Lys Ile Leu Asn Lys Ile Asn Ile Gly Glu Asn Lys Thr 
385                 390                 395                 400 


Arg Phe Tyr Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn 
                405                 410                 415     


Lys Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Ser Lys 
            420                 425                 430         


Asn Thr Thr His Lys Val Lys Phe Asn Leu Leu Gln Pro Leu Pro Glu 
        435                 440                 445             


Val Phe Leu Ser Ile His Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr 
    450                 455                 460                 


Leu Glu Gln Gly Lys Thr Glu Lys Leu Ile Asn Asn Phe Ile Lys Leu 
465                 470                 475                 480 


Ser Asn Ser Thr Ile Leu Asn Lys Lys Phe Ile Glu Thr Ile Lys Tyr 
                485                 490                 495     


Lys Leu Ser Asp Leu Asp Val Phe His Lys Arg Ser Met Gly Arg Lys 
            500                 505                 510         


Glu Ile Ser Ala Tyr Arg Lys Asp Ile Leu Lys Tyr Leu Ile Ala Arg 
        515                 520                 525             


Lys Glu Lys Leu Asn Gln Ile Leu Ser Glu His Asn Leu Ser Val Lys 
    530                 535                 540                 


Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp Leu Asn Ile Ala Asp Val 
545                 550                 555                 560 


Gln Glu Lys Thr Ala Ile Ser Asp Arg Ile Lys Leu Met Lys Arg Asp 
                565                 570                 575     


Cys Met Asp Arg Leu Lys Ala Ile Lys Lys Asn Asn Ala Pro Lys Ile 
            580                 585                 590         


Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile Val Asp Met Leu Ile 
        595                 600                 605             


Ser Glu Gly Lys Lys Lys Lys Ile Thr Ser Phe Tyr Tyr Asp Lys Met 
    610                 615                 620                 


Gln Glu Cys Leu Val Leu Phe Ala Asp Lys Glu Lys Lys Glu Leu Phe 
625                 630                 635                 640 


Ile Ser Ile Cys Ser Glu Leu Lys Leu Asn Asp Ala Asp Gly His Pro 
                645                 650                 655     


Phe Leu Lys Asn Ile Asn Leu Ser Asp Ile Arg Tyr Thr Ser Asp Leu 
            660                 665                 670         


Tyr Lys Ile Tyr Leu Gln Glu Lys Ala Asp Asn Arg Asn Gln Arg Asn 
        675                 680                 685             


Arg Thr Asp Thr Ser Trp Leu Ala Lys Asn Phe Tyr Thr Leu Lys Asn 
    690                 695                 700                 


Val Glu Val Phe Asp Lys Lys Gln Gln Arg Lys Ile Phe Lys Leu Gln 
705                 710                 715                 720 


Thr Ile Val Glu Leu Pro Gln Asp Lys Ser Lys Ile Pro Phe Thr Ile 
                725                 730                 735     


Arg Gln Leu Glu Lys Glu Lys Ser Ser Phe Asn Lys Trp Leu Glu Tyr 
            740                 745                 750         


Ile Thr Lys Gly Lys Glu Thr Thr Asp Lys Lys Lys Pro Val Asn Leu 
        755                 760                 765             


Pro Ala Asn Leu Phe Asp Asp Thr Leu Lys Lys Leu Leu Lys Thr Glu 
    770                 775                 780                 


Leu Ser Lys Asn Asn Ile Gln Tyr Asn Lys Glu Ala Asn Tyr Asn Gln 
785                 790                 795                 800 


Leu Phe Lys Ile Trp Trp Lys Glu Phe Arg Lys Asp Asn Thr Gln Asn 
                805                 810                 815     


Phe Tyr Thr Ala Glu Arg Glu Tyr Thr Phe Glu Glu Glu Lys Leu Asn 
            820                 825                 830         


Phe Lys Ile Asn Thr Gln Pro Lys Phe Glu Asn Tyr Tyr Thr Arg Phe 
        835                 840                 845             


Ala Glu Asn Val Phe Asn Lys Lys Gln Ala Leu Arg Asn Glu Glu Arg 
    850                 855                 860                 


Lys Thr Lys Arg Asn Leu Pro Pro Ile Gln Lys Ile His Val Ile Lys 
865                 870                 875                 880 


Lys Ile Arg Asn Lys Ile Gly Asn Thr Glu Lys Glu Ile Arg Met Leu 
                885                 890                 895     


Gln Glu Glu Asp Arg Leu Met Leu Leu Met Phe Glu Lys Leu Thr Lys 
            900                 905                 910         


Glu Asn Leu Asn Leu Lys Leu Glu Lys Val Asn Glu Leu Leu Asn Glu 
        915                 920                 925             


Arg Ile Glu Ile Lys Glu Lys Ile Pro Gly Lys Leu Ser Phe Asp Asp 
    930                 935                 940                 


Leu Gly Glu Lys Thr Ile Thr Arg Asn Ile Val Glu Thr Arg Lys Arg 
945                 950                 955                 960 


Lys Glu Tyr Ser Val Leu Gln Lys Tyr Ile Phe Asp Arg Arg Leu Pro 
                965                 970                 975     


Glu Leu Phe Glu Tyr Phe Asn Glu Thr Asp Ile Leu Ile Glu Lys Ile 
            980                 985                 990         


Lys Thr Glu Leu Asp Ala Tyr Asn  Lys Ala Lys Asp Ile  Val Phe Asp 
        995                 1000                 1005             


Leu Ile  Phe Lys Leu Glu Glu  Ala Ile Ile Lys Lys  Asp Glu Thr 
    1010                 1015                 1020             


Gly Ile  Lys Glu Leu Asn Lys  Asp Gln Asn Gly Asn  Ile Gln Thr 
    1025                 1030                 1035             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu His Trp Leu  Leu Lys Lys 
    1040                 1045                 1050             


Asn Met  Ile Thr Glu Lys Glu  Phe Thr Phe Ile Asn  Met Val Arg 
    1055                 1060                 1065             


Asn Thr  Phe Ser His Asn Arg  Phe Pro Gln Lys Lys  Thr Met Glu 
    1070                 1075                 1080             


Leu Phe  Ile Lys Lys Trp Asn  Asp Asn Asn Phe Ala  Tyr Gln Ile 
    1085                 1090                 1095             


Leu Glu  Thr Tyr Lys Gln Lys  Thr Asn Asn Ile Ile  Glu Lys Leu 
    1100                 1105                 1110             


Lys Asp  Met 
    1115     


<210>  2744
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2744

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2745
<211>  1146
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2745

Met Glu Ser Ile Ile Gly Leu Gly Leu Ser Phe Asn Pro Tyr Lys Thr 
1               5                   10                  15      


Ala Asp Lys His Tyr Phe Gly Ser Phe Leu Asn Leu Ala Asp Asn Asn 
            20                  25                  30          


Leu Lys Ala Val Phe Ala Glu Phe Lys Glu Arg Ile Ser Asp Lys Ser 
        35                  40                  45              


Lys Asp Glu Asp Ile Ser Asn Leu Ile Glu Lys His Phe Ile Asp Asn 
    50                  55                  60                  


Met Ser Ile Val Asp Tyr Glu Lys Asn Ile Ser Ile Leu Asn Gly Tyr 
65                  70                  75                  80  


Leu Pro Ile Ile Asp Phe Leu Asp Asp Glu Leu Glu Asn Asn Leu Asn 
                85                  90                  95      


Thr Arg Val Lys Asn Phe Lys Lys Ser Phe Ile Ile Leu Ala Glu Ala 
            100                 105                 110         


Leu Glu Thr Leu Arg Asn Tyr Tyr Thr His Phe Tyr His Asp Pro Ile 
        115                 120                 125             


Thr Phe Gly Asp Asn Lys Glu Pro Leu Leu Glu Leu Leu Asp Glu Val 
    130                 135                 140                 


Leu Leu Lys Thr Ile Leu Asp Val Lys Lys Lys Tyr Leu Lys Thr Asp 
145                 150                 155                 160 


Lys Thr Lys Glu Ile Leu Lys Asp Ser Leu Arg Glu Glu Met Asp Leu 
                165                 170                 175     


Leu Val Ile Arg Lys Thr Asp Glu Leu Arg Glu Lys Lys Lys Thr Asn 
            180                 185                 190         


Pro Lys Phe Lys Phe Ser Thr Asp Pro Thr Gln Ile Arg Asn Ser Ile 
        195                 200                 205             


Phe Asn Asp Ala Phe Gln Gly Leu Leu Tyr Glu Asp Lys Glu Asn Asn 
    210                 215                 220                 


Gly Lys Thr Gln Val Ser Tyr Arg Ala Lys Thr Lys Leu Asn Pro Lys 
225                 230                 235                 240 


Asp Ile His Lys Gln Glu Glu Arg Asp Phe Glu Ile Pro Leu Ser Thr 
                245                 250                 255     


Ser Gly Ile Val Phe Leu Met Ser Leu Phe Leu Ser Lys Lys Glu Ile 
            260                 265                 270         


Glu Asp Phe Lys Ser Asn Ile Lys Gly Phe Lys Gly Lys Val Val Lys 
        275                 280                 285             


Asp Glu Asn His Asn Ser Leu Lys Tyr Met Ala Thr His Arg Val Tyr 
    290                 295                 300                 


Ser Ile Leu Ala Phe Lys Gly Leu Lys Tyr Arg Ile Lys Thr Asp Thr 
305                 310                 315                 320 


Phe Ser Lys Val Thr Leu Met Met Gln Met Ile Asp Glu Leu Ser Lys 
                325                 330                 335     


Val Pro Asp Cys Val Tyr Gln Asn Leu Ser Glu Thr Lys Gln Lys Asp 
            340                 345                 350         


Phe Ile Glu Asp Trp Asn Glu Tyr Leu Lys Asp Asn Glu Glu Asn Thr 
        355                 360                 365             


Glu Asn Leu Glu Asn Ser Arg Val Val His Pro Leu Ile Arg Lys Arg 
    370                 375                 380                 


Tyr Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe 
385                 390                 395                 400 


Ala Asn Phe Lys Thr Leu Lys Phe Gln Val Phe Met Gly Tyr Tyr Ile 
                405                 410                 415     


His Asp Gln Arg Thr Lys Thr Ile Gly Thr Thr Asn Ile Thr Thr Glu 
            420                 425                 430         


Arg Thr Val Lys Glu Lys Ile Asn Val Phe Gly Lys Leu Ser Lys Met 
        435                 440                 445             


Asp Asn Leu Lys Lys His Phe Phe Ser Gln Leu Ser Asp Glu Glu Asn 
    450                 455                 460                 


Thr Asp Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Phe Leu Thr Gln 
465                 470                 475                 480 


Ala Asp Asn Ser Pro Ala Asn Asn Ile Pro Ile Tyr Leu Glu Leu Lys 
                485                 490                 495     


Asn Gln Gln Ile Ile Lys Glu Lys Asp Asp Ile Lys Ala Glu Val Asn 
            500                 505                 510         


Asn Ser Gln Asn Arg Asn Pro Asn Lys Pro Ser Lys Arg Asp Leu Leu 
        515                 520                 525             


Asn Lys Ile Ser Asn Thr Asn Glu Asp Phe Tyr Gln Gly Asp Pro Thr 
    530                 535                 540                 


Ala Ile Leu Ser Leu Asn Glu Ile Pro Ala Leu Leu His Leu Phe Leu 
545                 550                 555                 560 


Val Gln Pro Asp Asn Lys Thr Gly Gln Gln Ile Glu Asn Ile Ile Arg 
                565                 570                 575     


Ile Lys Ile Glu Lys Gln Phe Asn Ser Ile Lys Asn Pro Ser Lys Asp 
            580                 585                 590         


Asp Lys Gly Val Pro Lys Ser Leu Phe Ala Asp Thr Asn Val Arg Val 
        595                 600                 605             


Asn Ala Ile Lys Leu Lys Lys Asp Leu Gly Glu Glu Leu Asp Met Leu 
    610                 615                 620                 


Asn Lys Lys Gln Ile Val Phe Lys Glu Asn Gln Lys Ala Ser Ser Asn 
625                 630                 635                 640 


Tyr Asp Glu Leu Leu Lys Lys His Gln Phe Thr Pro Lys Asn Lys Arg 
                645                 650                 655     


Pro Ala Leu Arg Lys Tyr Val Phe Tyr Asn Ser Glu Lys Gly Glu Glu 
            660                 665                 670         


Ala Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Lys Gly Phe 
        675                 680                 685             


Lys Thr Lys Trp Lys Gly Tyr Gln His Ser Glu Leu Gln Arg Lys Leu 
    690                 695                 700                 


Ala Phe Tyr Asp Arg His Thr Lys Gln Asp Ile Lys Glu Leu Leu Ser 
705                 710                 715                 720 


Gly Cys Glu Phe Asp His Phe Leu Leu Asp Ile Asn Ala Cys Phe Lys 
                725                 730                 735     


Glu Asp Asp Phe Glu Asp Phe Phe Ser Lys Tyr Leu Lys Asn Arg Ile 
            740                 745                 750         


Glu Thr Leu Asn Ile Ile Leu Lys Gln Leu His Asp Phe Lys Asn Glu 
        755                 760                 765             


Pro Thr Pro Leu Lys Gly Val Phe Lys Asn Cys Leu Lys Phe Leu Lys 
    770                 775                 780                 


Gln Lys Asn Tyr Val Thr Glu Asn Pro Glu Ile Ile Lys Lys Arg Ile 
785                 790                 795                 800 


Leu Ala Lys Pro Ala Phe Leu Pro Arg Gly Ile Phe Asp Glu Arg Pro 
                805                 810                 815     


Thr Met Lys Lys Gly Lys Asn Pro Leu Ile Asp Arg Asp Glu Phe Ala 
            820                 825                 830         


Lys Trp Phe Val Glu Tyr Leu Glu Asn Lys Asp Tyr Gln Lys Phe Tyr 
        835                 840                 845             


Asn Ser Glu Glu Tyr Arg Ile Arg Asp Ala Asp Phe Lys Lys Asn Ala 
    850                 855                 860                 


Val Ile Lys Lys Gln Lys Leu Lys Asp Phe Tyr Thr Leu Gln Met Val 
865                 870                 875                 880 


Asn Tyr Leu Leu Lys Glu Val Phe Gly Lys Asp Glu Met Asn Leu Gln 
                885                 890                 895     


Leu Ser Glu Leu Phe Gln Thr Arg Gln Glu Arg Leu Lys Leu Gln Gly 
            900                 905                 910         


Ile Ala Lys Lys Gln Met Asn Lys Glu Thr Gly Asp Ser Ser Glu Asn 
        915                 920                 925             


Thr Arg Asn Gln Thr Tyr Ile Trp Asn Lys Asp Val Pro Val Ser Phe 
    930                 935                 940                 


Phe Asn Gly Lys Val Thr Ile Asp Lys Val Lys Leu Lys Asn Ile Gly 
945                 950                 955                 960 


Lys Tyr Lys Arg Tyr Glu Arg Asp Glu Arg Val Lys Thr Phe Ile Gly 
                965                 970                 975     


Tyr Glu Val Asp Glu Lys Trp Met Met Tyr Leu Pro His Asn Trp Lys 
            980                 985                 990         


Asp Arg Tyr Ser Val Lys Pro Ile  Asn Val Ile Asp Leu  Gln Ile Gln 
        995                 1000                 1005             


Glu Tyr  Glu Glu Ile Arg Ser  His Glu Leu Leu Lys  Glu Ile Gln 
    1010                 1015                 1020             


Asn Leu  Glu Gln Tyr Ile Tyr  Asp His Thr Thr Asp  Lys Asn Thr 
    1025                 1030                 1035             


Leu Leu  Gln Asp Gly Asn Pro  Asn Phe Lys Met Tyr  Val Leu Asn 
    1040                 1045                 1050             


Gly Leu  Leu Thr Gly Ile Lys  Gln Val Asn Ile Ala  Asp Phe Ile 
    1055                 1060                 1065             


Val Leu  Lys Gln Asn Thr Asn  Phe Asp Lys Ile Asp  Phe Thr Gly 
    1070                 1075                 1080             


Ile Ala  Ser Cys Ser Glu Leu  Glu Lys Lys Thr Ile  Ile Leu Ile 
    1085                 1090                 1095             


Ala Ile  Arg Asn Lys Phe Ala  His Asn Gln Leu Pro  Asn Lys Thr 
    1100                 1105                 1110             


Ile Tyr  Asp Leu Ala Asn Glu  Phe Leu Lys Lys Glu  Lys Arg Glu 
    1115                 1120                 1125             


Thr Tyr  Ala Asn Tyr Tyr Leu  Lys Val Leu Lys Lys  Met Ile Ser 
    1130                 1135                 1140             


Asp Leu  Ala 
    1145     


<210>  2746
<211>  1012
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2746

Met Glu Asn Asp Gln Gln Ile Leu Glu Asn Arg Arg Arg Thr Leu Ala 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Tyr Asn Ile Ser Asn His Leu Ala Ala Ser Phe Glu Gln Lys Val 
        35                  40                  45              


Leu Pro Glu Glu Gly Gln Ile Pro Ala Ser Phe Leu Cys Asn Lys Ser 
    50                  55                  60                  


Ile Lys Lys Ile Asn Trp Asn His Val Tyr Ser Lys Ala Arg Arg Phe 
65                  70                  75                  80  


Leu Pro Ile Leu Lys Val Phe Asp Ala Asp Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Arg Glu Thr Thr Asp Lys Glu Gly Lys Asp Phe Thr Ala Met Asn Glu 
            100                 105                 110         


Thr Leu Lys Leu Val Phe Asp Glu Leu Gln Ala Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Ala Asp Ser Arg Lys Leu Thr Ile 
    130                 135                 140                 


Ser Val Glu Leu Ala Asp Phe Leu Thr Val Asn Phe Lys Arg Ala Ile 
145                 150                 155                 160 


Ala Tyr Thr Lys Val Arg Met Lys Asp Val Leu Ala Asp Asp Asp Tyr 
                165                 170                 175     


Thr Met Val Glu Ser Lys Gln Ile Val Thr Pro Asp Asn Leu Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Phe Leu Thr Cys Met Phe Leu Glu Arg Glu Gln 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Val Gln Gly Leu Lys Gly Thr Gln Phe 
    210                 215                 220                 


Asn Ser Phe Ile Ala Thr Arg Glu Val Leu Leu Ala Tyr Cys Val Lys 
225                 230                 235                 240 


Leu Pro His Asp Lys Phe Val Ser Glu Asp Leu Gly Gln Ala Leu Thr 
                245                 250                 255     


Leu Asp Ile Ile Asn Glu Leu Asn Arg Cys Pro Lys Thr Leu Tyr Glu 
            260                 265                 270         


Val Ile Thr Glu Glu Glu Lys Gln Gln Phe Arg Pro Glu Leu Asp Ala 
        275                 280                 285             


Gln Gly Ile Asp Asn Leu Ile Ala Asn Ser Thr Asn Glu Glu Glu Arg 
    290                 295                 300                 


Glu Lys Ile Leu Asp Glu Ile Asp Tyr Glu Asp Tyr Ile Glu Ser Leu 
305                 310                 315                 320 


Thr Arg Arg Val Arg His Ser Asn Arg Phe Ser Tyr Phe Ala Met Arg 
                325                 330                 335     


Tyr Ile Glu Glu Lys Asn Val Phe Asp Lys Leu Arg Phe His Ile Asp 
            340                 345                 350         


Leu Gly Lys Tyr Glu Val Asp Lys Tyr Asn Lys Gln Phe Asp Gly Glu 
        355                 360                 365             


Ala Thr Glu Cys Lys Val Val Glu Asn Ala Lys Ala Phe Gly Lys Leu 
    370                 375                 380                 


Ser Ser Phe Thr Asn Gln Glu Thr Val Glu Leu Lys Ile Asp Ser Ala 
385                 390                 395                 400 


Gln Arg Thr Asn Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Ala Asp 
                405                 410                 415     


Asn Asn Lys Ile Gly Leu Ser Asn Lys Glu Ser Glu Ala Arg Leu Leu 
            420                 425                 430         


Thr Lys Ala Lys Pro Glu Ser Lys Val Ser Tyr Asn Leu Lys Gln Pro 
        435                 440                 445             


Leu Pro Gln Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile Leu 
    450                 455                 460                 


Leu Glu Tyr Leu Gln Lys Gly Lys Ala Glu Glu Met Ile Asn Asp Phe 
465                 470                 475                 480 


Ile Lys Val Asn Asp Ser Gln Leu Met Ser Met Gln Phe Ile Asp Glu 
                485                 490                 495     


Ile Lys Glu Gln Leu Pro Ala Asp Trp Asn Glu Phe Gly Lys Arg Ser 
            500                 505                 510         


Asp Ser Lys Lys Lys Lys Ala Tyr Thr Asn Ala Ala Leu Gln Tyr Leu 
        515                 520                 525             


Leu Gln Arg Lys Ala Thr Leu Asn Lys Val Leu Ala Asn Tyr Gln Leu 
    530                 535                 540                 


Asn Asp Lys Gln Val Pro Thr Arg Ile Leu Asn Tyr Trp Leu Asn Ile 
545                 550                 555                 560 


Lys Glu Val Asp Asp Ser Arg Ser Val Ser Asp Arg Ile Lys Leu Met 
                565                 570                 575     


Lys Arg Asp Cys Met Ser Arg Leu Lys Val Val Glu Lys His Lys Leu 
            580                 585                 590         


Asp Lys Ser Ala Arg Thr Pro Lys Val Gly Glu Met Ala Thr Phe Leu 
        595                 600                 605             


Ala Lys Asp Ile Val Asp Met Ile Val Ser Thr Asp Lys Lys Gln Lys 
    610                 615                 620                 


Ile Thr Ser Phe Phe Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Tyr 
625                 630                 635                 640 


Ala Asp Thr Asp Lys Lys Ala Thr Phe Ile His Ile Val Thr Asn Glu 
                645                 650                 655     


Leu Lys Leu Leu Glu Lys Gly Gly His Pro Phe Leu Ala Asn Ile Asn 
            660                 665                 670         


Leu Arg Gln Ile Arg Lys Thr Ser Gln Leu Tyr Glu Leu Tyr Leu Val 
        675                 680                 685             


Glu Lys Ala Asn Lys Gln Val Lys Lys Met Asn Pro Lys Thr Gln Arg 
    690                 695                 700                 


Thr Ser Asn Val Asp Glu Ser Trp Met Met Lys Ser Phe Tyr Ala Lys 
705                 710                 715                 720 


Glu Trp Asn Glu Glu Met Gly Lys Gln Leu Thr Val Val Lys Leu Pro 
                725                 730                 735     


Val Asn Lys Thr Asn Ile Pro Phe Thr Ile Arg Gln Trp Glu Glu Lys 
            740                 745                 750         


Glu Lys His Asn Leu Gln Ala Trp Leu His Asn Ile Thr Lys Gly Lys 
        755                 760                 765             


Thr Ser Lys Asp Gly Lys Lys Ala Ile Asp Leu Pro Thr Asn Leu Phe 
    770                 775                 780                 


Asp Asp Thr Leu Cys Glu Leu Leu Arg Glu Ala Leu Ile Asn Gln Gly 
785                 790                 795                 800 


Ile Asp Ala Thr Pro Thr Thr Lys Tyr Asn Glu Leu Leu Lys Gln Trp 
                805                 810                 815     


Trp Thr Ala Arg Glu Asp Ser Thr Gln Asp Phe Tyr Leu Ser Glu Arg 
            820                 825                 830         


Gln Tyr Asp Ile Tyr Asp Glu Lys Val Cys Phe Thr Ile Asn Ser Ser 
        835                 840                 845             


Ala His Phe Ala Asp Tyr Tyr Ala Pro Ala Leu Asn Lys Ala Tyr Ser 
    850                 855                 860                 


Arg Leu Arg Ala Glu Arg Asp Val Ala Arg Arg Thr Asp Lys Arg Leu 
865                 870                 875                 880 


Pro Pro Val Glu Arg Lys Asp Val Glu Arg Val Phe Lys Asn Thr Ile 
                885                 890                 895     


Ala Glu Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Met 
            900                 905                 910         


Ala Val Leu Met Leu Glu Gln Leu Met Asp Asn Gln Gln Gln Leu Lys 
        915                 920                 925             


Leu Ser Lys Met Asp Ser Leu Leu Asn Glu Thr Lys Arg Ile Glu Gln 
    930                 935                 940                 


Thr Ile Asn Thr Gln Leu Ser Phe Asp His Lys Gly Lys Glu Ile Lys 
945                 950                 955                 960 


Asp Lys Thr Asn Ser Glu Ile Val Lys Thr Ile Val Ala Glu Arg Lys 
                965                 970                 975     


Gln Lys Asn Tyr Thr Glu Met Arg Lys Tyr Val His Asp Arg Arg Leu 
            980                 985                 990         


Pro Glu Leu Phe Glu Tyr Ile Asp  Gly Asn Glu Leu Pro  Leu Asp Val 
        995                 1000                 1005             


Leu Leu  Asn Glu 
    1010         


<210>  2747
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2747

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Ile Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Arg Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Val Asn Asn Asn Gly Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Thr Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Leu Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Leu Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2748
<211>  1131
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2748

Met Glu Lys Thr Ile Glu Asn Gln Thr Gln Ser Lys Arg Thr Leu Asn 
1               5                   10                  15      


Asn Asp Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Asp Glu Glu Lys Ile Thr Thr Ser Phe Leu Val Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Arg Gln Ser Leu Val Tyr Ser Asn Leu Thr 
65                  70                  75                  80  


Arg Tyr Met His Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Asp 
                85                  90                  95      


Asp Glu Arg Asp Lys Ala Glu Asn Tyr Gly Lys Asp Phe Gly Asn Leu 
            100                 105                 110         


Thr Asp Thr Leu Lys Glu Ile Phe Lys Glu Leu Asn Glu Phe Arg Asn 
        115                 120                 125             


Asp Tyr Ser His Tyr Tyr Ser Thr Glu Lys Lys Asp Lys Arg Lys Thr 
    130                 135                 140                 


Ile Val Ser Asp Lys Leu Lys Asn Phe Leu Asn Ile Asn Tyr Thr Arg 
145                 150                 155                 160 


Ala Ile Lys Tyr Thr Lys Ser Arg Phe Ile Asn Val Phe Ser Asp Asn 
                165                 170                 175     


Asn Phe Cys Leu Ala Glu Glu Ala Lys His Val Glu Asn Asp Asn Thr 
            180                 185                 190         


Ile Thr Gln Asp Gly Ile Val Phe Phe Thr Ser Met Phe Leu Asp Arg 
        195                 200                 205             


Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile Ile Gly Leu Lys Gly Thr 
    210                 215                 220                 


Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Thr Leu Met Ala Phe Cys 
225                 230                 235                 240 


Val Asn Leu Pro His Asp Lys Phe Val Ser Glu Asn Ser Glu Gln Gln 
                245                 250                 255     


Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu 
            260                 265                 270         


Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln His Phe Leu Pro Lys Leu 
        275                 280                 285             


Asp Asp Glu Gln Ile Asp Asn Val Leu Glu Asn Ser Val Pro Tyr Thr 
    290                 295                 300                 


Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn Ile Thr Lys Lys Val Arg 
305                 310                 315                 320 


Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu Lys Phe Ile Asp Gln Lys 
                325                 330                 335     


Lys Leu Phe Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val 
            340                 345                 350         


Leu Asp Glu Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Lys Arg Thr 
        355                 360                 365             


Val Thr Glu Asn Thr Lys Ala Phe Gly Met Leu Gln Asp Leu Asn Asp 
    370                 375                 380                 


Glu Glu Asn Val Leu Asn Lys Ile Asn Thr Gly Glu Ser Lys Ala Lys 
385                 390                 395                 400 


Phe Asp Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Thr Lys Asn 
            420                 425                 430         


Thr Asp Asn Lys Ile Lys Ser Asn Leu Leu Gln Pro Leu Pro Glu Ala 
        435                 440                 445             


Phe Leu Ser Ile Asn Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
    450                 455                 460                 


Glu Gln Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn 
465                 470                 475                 480 


Asn Ser Lys Ile Leu Asn Lys Glu Phe Ile Lys Ala Ile Lys Leu Lys 
                485                 490                 495     


Leu Asn Asp Leu Asp Val Phe Tyr Lys Arg Ser Gln Gly Arg Lys Gln 
            500                 505                 510         


Lys His Ala Tyr Leu Thr Lys Asp Lys Lys Tyr Asp Asn Glu Lys Ile 
        515                 520                 525             


Asn Glu Leu Lys Asn Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu 
    530                 535                 540                 


Tyr Asn Leu Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp 
545                 550                 555                 560 


Leu Asn Ile Ala Asp Val Gln Ala Lys Asn Ala Ile Ser Asp Arg Ile 
                565                 570                 575     


Lys Leu Met Lys Arg Asp Cys Ile Asn Arg Leu Lys Ser Met Lys Lys 
            580                 585                 590         


Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp 
        595                 600                 605             


Ile Val Asp Met Ile Ile Asp Glu Glu Lys Lys Lys Lys Ile Thr Ser 
    610                 615                 620                 


Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Lys 
625                 630                 635                 640 


Glu Lys Lys Glu Leu Phe Ile Leu Ile Cys Asn Asn Glu Leu Lys Leu 
                645                 650                 655     


Asn Asp Asp Asp Gly His Pro Phe Phe Lys Asn Ile Asn Phe Ser Asn 
            660                 665                 670         


Tyr Lys Tyr Thr Ser Glu Ile Tyr Gln Lys Tyr Leu Glu Glu Lys Gly 
        675                 680                 685             


His Lys Met Val Lys Glu Tyr Asn Pro Arg Lys Glu Asn Tyr Val Glu 
    690                 695                 700                 


Lys Asp Lys Ser Trp Leu Glu Ile Asn Phe Tyr Lys Lys Glu Trp Asn 
705                 710                 715                 720 


Glu Asn Ala Lys Lys Asp Leu Thr Val Val Lys Leu Pro Asp Asp Lys 
                725                 730                 735     


Ser Lys Ile Pro Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser 
            740                 745                 750         


Phe Glu Asn Trp Phe Lys Tyr Val Thr Asn Gly Lys Glu Thr Thr Asp 
        755                 760                 765             


Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp Glu Thr Leu 
    770                 775                 780                 


Lys Glu Leu Leu Lys Lys Glu Leu Ser Lys Asn Asn Ile Glu Phe Lys 
785                 790                 795                 800 


Glu Glu Asp Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Asp Lys Cys 
                805                 810                 815     


Arg Asn Asp Lys Thr Gln Lys Phe Tyr Ser Ala Glu Arg Glu Tyr Thr 
            820                 825                 830         


Phe Glu Glu Glu Lys Leu Asn Phe His Ile Asn Thr Lys Ser Lys Phe 
        835                 840                 845             


Glu Glu Tyr Ile Asn Pro Glu Phe Ala Glu Lys Val Phe Arg Leu Lys 
    850                 855                 860                 


Asn Gln Asn Arg Glu Lys Asp Asn Ile Ser Gly Arg Arg Leu Pro Pro 
865                 870                 875                 880 


Leu Lys Met Lys Glu Val Thr Lys Asn Met Val Lys Arg Ile Gly Asn 
                885                 890                 895     


Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Leu Met Leu 
            900                 905                 910         


Leu Met Phe Glu Lys Leu Val Asp Asn Asn Leu Lys Leu Lys Leu Glu 
        915                 920                 925             


Asn Val Asp Lys Leu Leu Asn Glu Ser Ile Glu Ile Asn Gln Ser Ile 
    930                 935                 940                 


Ser Gly Lys Leu Ser Phe Asn Asp Ser Gly Asp Asn Glu Asn Lys Lys 
945                 950                 955                 960 


Asp Arg Ala Ile Ile Cys Arg Asn Ile Thr Glu Thr Arg Lys Arg Lys 
                965                 970                 975     


Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Glu Glu Glu  Asn Ile Pro Ile Glu  Lys Ile Lys 
        995                 1000                 1005             


Ile Glu  Leu Asp Thr Tyr Ser  Lys Ala Lys Asp Val  Val Phe Asp 
    1010                 1015                 1020             


Leu Ile  Phe Asp Leu Glu Arg  Ala Ile Ile Asn Lys  Asp Glu Asn 
    1025                 1030                 1035             


Arg Ile  Lys Glu Leu Asn Lys  Asp Lys Asn Gly Val  Ile Gln Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Phe Trp Leu  Leu Glu Lys 
    1055                 1060                 1065             


Asn Leu  Ile Thr Glu Gln Glu  Phe Thr Phe Met Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Thr  Phe Ser His Asn Gln  Phe Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Leu Phe  Ile Lys Asn Trp Asn  Glu Asn Glu Phe Ala  Lys Gln Ile 
    1100                 1105                 1110             


Leu Asn  Val Tyr Asn Gln Lys  Asn Asn Asn Leu Ile  Lys Ser Ile 
    1115                 1120                 1125             


Lys Asp  Ile 
    1130     


<210>  2749
<211>  1081
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2749

Met Lys Lys Thr Asn Thr Tyr Phe Asp Phe Lys Asp Lys Thr Gln Lys 
1               5                   10                  15      


Tyr Phe Phe Ala Gly Leu Phe Asn Thr Ala Leu Asn Asn Phe Asp Leu 
            20                  25                  30          


Ser Leu Asp Glu Leu Ala Asn Arg Thr Gly Leu Lys Cys Asn Gly Lys 
        35                  40                  45              


Glu Leu Ile Ala Val Ala Phe Asn Asp Thr Cys Ser Gln Thr Asp Tyr 
    50                  55                  60                  


Asn Asn Arg Leu Ser Tyr Leu Ser Glu Ser Leu Ala Phe Ile Glu Leu 
65                  70                  75                  80  


Ile Lys Thr Lys Glu Arg Ser Tyr Ile Arg Leu His Leu Thr Glu Leu 
                85                  90                  95      


Tyr Asn Leu Ile Asp Asn Tyr Arg Asn Tyr Phe Thr His Leu Glu His 
            100                 105                 110         


Pro Gly Leu Ile Ile Lys Pro Leu Ile Phe Lys Leu Leu Asp Leu Phe 
        115                 120                 125             


Ile Leu Glu Ser Ala Arg Thr Val Ile Lys Glu Arg Val Lys Thr Glu 
    130                 135                 140                 


Glu Asn Lys Ser Tyr Leu Ser Lys Lys Phe Lys Leu Glu Ile Thr Ser 
145                 150                 155                 160 


Thr Phe Glu Ala Ala Asn Asn Ala Ile Asn Leu Glu Asn Lys Asn Asn 
                165                 170                 175     


Pro His Ser Lys Thr His Lys Lys Leu Ile Thr Gln Asn Asp Lys Ile 
            180                 185                 190         


Asn Phe Val Leu Ile Asn Ala Phe Tyr Asn Phe Leu Ile Asn Thr Asp 
        195                 200                 205             


Glu Ile Pro Thr Leu Lys Glu Thr Ala Arg Ser Ile Asn Lys Asp Thr 
    210                 215                 220                 


Gly Gln Ile Ser Gln Asn Gly Ile Ile Gln Leu Leu Ala Ile Phe Leu 
225                 230                 235                 240 


Asn Lys Lys Gln Leu Glu Ile Leu Phe Asp Asn Thr His Tyr Leu Lys 
                245                 250                 255     


Gly Thr Leu Lys Leu Asn His Leu Cys Thr Arg Trp Thr Tyr Ser Gln 
            260                 265                 270         


Leu Ala Tyr Arg Asn Ile Lys Lys Leu Leu Lys Ser Asp Tyr Ser Asn 
        275                 280                 285             


Asp Ser Leu Ile Leu Gln Met Leu Ser Glu Leu Thr Lys Cys Pro Lys 
    290                 295                 300                 


His Leu Tyr Pro Asn Leu Pro Asn Asn Ser Lys Gln Glu Phe Ile Glu 
305                 310                 315                 320 


Asp Leu Asn Glu Tyr Leu Lys Glu Thr Glu Tyr Phe Lys Asp Ser Ile 
                325                 330                 335     


Ala Gln Glu Thr Val Ser Asn Glu Val Ile Arg Lys Arg Tyr Glu Asp 
            340                 345                 350         


Lys Phe Pro Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe Ile Asp Phe 
        355                 360                 365             


Pro Asn Leu Arg Phe Gln Ile Asn Leu Gly Lys Phe Asn His Asn Thr 
    370                 375                 380                 


Cys Leu Lys Lys Phe Glu Asn Thr Ala Val Tyr Thr Glu Arg Gln Ile 
385                 390                 395                 400 


Leu Glu Lys Leu Thr Ile Phe Glu Lys Leu Thr Leu Ala Thr Asn Lys 
                405                 410                 415     


Lys Thr Glu Tyr Phe Leu Asn Asn Asn Leu Pro Asp Ser Glu Gly Trp 
            420                 425                 430         


Gln Glu Tyr Pro Lys Pro Ser Tyr Gln Phe Tyr Asn Asn Asn Ile Gly 
        435                 440                 445             


Phe Trp Leu Gly Ile Lys Asn Gly Ala Val Thr Asp Ala Lys Glu Lys 
    450                 455                 460                 


Arg Glu Asn Asp Lys Ser Ser Lys Phe Asp Ile Leu Lys Lys Ile Gly 
465                 470                 475                 480 


Leu Glu Cys Cys Leu Lys Lys Pro Val Ala Tyr Leu Ser Phe Asn Glu 
                485                 490                 495     


Leu Pro Ala Leu Leu Tyr Thr Val Leu Ile Glu Lys Lys Thr Ala Lys 
            500                 505                 510         


Glu Val Glu Arg Ile Phe Leu Lys Lys Ile Gly Glu Gln Thr Gly Ala 
        515                 520                 525             


Ile Asn Lys Phe Ala Asp Ile Asn Asn Phe Glu Lys Lys Ile Ile Pro 
    530                 535                 540                 


His Lys Phe Lys Glu Ile Leu Glu Asn Lys Glu Ser Asn Val Lys Trp 
545                 550                 555                 560 


Glu Lys Leu Lys Lys Asp Ile Glu Lys Glu Met Leu Ile Ser Pro Leu 
                565                 570                 575     


Asp Glu Ile Arg Ile His Tyr Lys Thr Ala Ser Lys His Pro Asn Asp 
            580                 585                 590         


Leu Ser Phe Ser Glu Lys Gly Lys Ile Ala Thr Trp Leu Ala His Asp 
        595                 600                 605             


Ile Lys Arg Phe Val Lys Ala Glu Thr Lys Lys Asp Trp Lys Gly Tyr 
    610                 615                 620                 


Gln Phe Ser Glu Phe Gln Ser Leu Leu Ala Tyr Tyr Asp Leu Lys Lys 
625                 630                 635                 640 


Met Glu Leu Leu Asn Phe Val Asn Phe Val Leu Lys Ile Asn Ile Lys 
                645                 650                 655     


Gln Asp Ile Val Phe Glu Asp Ile Asp Phe Asn Gln Lys Thr Leu Tyr 
            660                 665                 670         


Asp Phe Tyr Lys Asn Tyr Leu Ser Asn Arg Lys Lys Phe Leu Glu Gly 
        675                 680                 685             


Asn Leu Tyr Ser Ile Asp Gln Lys Asp Glu Val Pro Ala Lys Leu Trp 
    690                 695                 700                 


Arg Lys Arg Glu Leu Ser Ile Phe Thr Gly Phe Asp Asp Lys Leu Tyr 
705                 710                 715                 720 


Lys Tyr Lys Asn Phe Lys Thr Tyr Lys Glu Asn Leu Met Asn Met Pro 
                725                 730                 735     


Leu Asn Leu Pro Arg Gly Ile Phe Ser Asp Lys Gln Thr Cys Tyr Asn 
            740                 745                 750         


Lys Asn Ser Gln Asn Asn Asn Glu Leu Ala Glu Trp Phe Thr Lys Ser 
        755                 760                 765             


Asn Asn Ile Asn Asp Phe Gln Lys Phe Tyr Ser Phe Thr Arg Phe Tyr 
    770                 775                 780                 


Glu Asn Cys Gln Leu Thr Leu Asn Pro Leu Lys Gly Leu Lys Glu Gln 
785                 790                 795                 800 


Asn Asn Asn Lys Gly Val Pro Lys Glu Val Tyr Lys Asn Glu Lys Asn 
                805                 810                 815     


Ile Arg Asn Thr Met Arg Gln Asp Phe Tyr Ile Phe Glu Met Val Lys 
            820                 825                 830         


Tyr Tyr Phe Lys Ile Asn Glu Ser Leu Lys Ser Asp Leu Asn Asp Leu 
        835                 840                 845             


Lys Leu Asn Thr Leu Phe Leu Thr Lys Gln Glu Lys Glu Asn Asn Leu 
    850                 855                 860                 


Lys Val Leu Asn Gln Gln His Ser Arg Ser Lys Gly Asp Lys Ser Glu 
865                 870                 875                 880 


Asn Ile Leu Asn Glu Asn Tyr Ile Leu Ser Lys His Ile Met Met Ser 
                885                 890                 895     


Ile Leu Glu Gly Lys Ile Gln Gly Met Val Ala Leu Lys Ser Val Gly 
            900                 905                 910         


Lys Tyr Arg Phe Leu Ser Gln Asp Lys Arg Val Lys Gln Leu Val Thr 
        915                 920                 925             


Tyr Ile Pro Asp Lys Ile Trp Ser Phe Glu Glu Ile Asn Ser Glu Ile 
    930                 935                 940                 


Asp Glu Tyr Asp Lys Ile Arg Thr Phe Ser Phe Phe Lys Ile Ile His 
945                 950                 955                 960 


Glu Ile Glu Glu Lys Ile Phe Asn Lys Ala Ile Asn Asn Lys Glu Glu 
                965                 970                 975     


Ser Tyr Leu Leu Val Asp Gly His Pro Asn Phe Lys Ala Tyr Ile Ile 
            980                 985                 990         


Tyr Tyr Phe Leu Lys Thr Gln Asp  Glu Lys Asp Phe Phe  Asn Lys Leu 
        995                 1000                 1005             


Asp Val  Lys Asn Val Asn Ile  Asn Asp Ile Ala Ile  Ser Lys Phe 
    1010                 1015                 1020             


Lys Leu  Leu Phe Leu Ile Ile  Lys Ile Arg Asn Lys  Ile Cys His 
    1025                 1030                 1035             


Asn Gln  Leu Ile Ser Ser Asp  Glu Phe Ile Phe Leu  Leu Glu Phe 
    1040                 1045                 1050             


Thr Pro  Ile Glu Pro Asp Glu  Leu Tyr Met Ser Tyr  Leu Leu Lys 
    1055                 1060                 1065             


Ala Tyr  Lys Lys Ile Val Asn  Ile Ser Trp Asn Leu  Val 
    1070                 1075                 1080     


<210>  2750
<211>  1124
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2750

Met Ser Val Ala Thr Gln Glu His Ile Asn Ser Leu Lys Phe Ile Glu 
1               5                   10                  15      


Thr Ala Glu Arg Asn Lys Phe Tyr Tyr Gly Met Tyr Leu Ser Val Ala 
            20                  25                  30          


Gln Arg Asn Ala Tyr Leu Ser Leu Lys Ser Ile Tyr Glu Lys Leu Glu 
        35                  40                  45              


Ile Lys Glu Glu Lys Arg Gln Ile Ser Glu Asp Asn Pro His Lys Ala 
    50                  55                  60                  


Asp Ile Phe Cys Glu Leu Ile Pro Pro Asp Glu Asn Thr Ser Asn Cys 
65                  70                  75                  80  


Asp Ala His Pro Tyr Val Gln Leu Arg Pro Ser Glu Ile Glu Ser Arg 
                85                  90                  95      


Lys Arg Leu Leu Ala Lys His Phe Pro Ala Phe Arg Lys Leu Ser Glu 
            100                 105                 110         


Thr Ile Asn Glu Lys Gly Lys Val Thr Gly Phe Asp Val Val Arg Leu 
        115                 120                 125             


Ala Lys Leu Leu Lys Cys Ser Leu Glu Tyr Leu Asn Lys Leu Arg Asn 
    130                 135                 140                 


Tyr Phe Ser His Tyr Tyr His Lys Pro Ile Ser Gly Asp Thr Ile Pro 
145                 150                 155                 160 


Asp Ile Tyr Leu Pro Glu Leu Leu Glu Ala Ala Val Glu Lys Val Gln 
                165                 170                 175     


Lys Arg Phe Pro Asp Ile Asn Thr Glu His Gly Glu Tyr Leu Lys Thr 
            180                 185                 190         


Leu Pro Leu Thr Val Asp Asn Gln Tyr Asn Tyr Asn Gly Gly Ile Leu 
        195                 200                 205             


Phe Met Cys Met Phe Leu Asp Arg Arg Asn Ala Phe Ala Phe Leu Lys 
    210                 215                 220                 


Thr Thr Tyr Met Arg Gly Phe Lys Asp Ser Arg Thr Pro Asp Met Arg 
225                 230                 235                 240 


Val Lys Pro Glu Ala Phe Ile Tyr Phe Cys Ala Arg Pro Pro Gln Pro 
                245                 250                 255     


Lys Leu Gly Ser Ser Asp Leu Pro Leu Asp Met Leu Thr Glu Ile Ser 
            260                 265                 270         


Arg Cys Pro Asn Glu Ile Phe Gln Leu Leu Ser Thr Asn Asp Lys Lys 
        275                 280                 285             


Lys Phe Glu Ala Asp Ile Asp Asp Asp Ala Lys Pro Thr Glu Leu Asp 
    290                 295                 300                 


Glu Phe Leu Lys Asp Glu Leu Pro Pro Arg Thr Ala Asn Met Lys Arg 
305                 310                 315                 320 


Lys Ala Glu Asn Ser His Phe Pro Arg Tyr Ala Met Arg Tyr Phe Asp 
                325                 330                 335     


Glu Gln Lys Lys Phe Gly Arg Leu Arg Phe Gln Leu Leu Cys Ala Lys 
            340                 345                 350         


Phe Asn Cys Ala Asp Tyr Lys Ser Thr Ile Leu Glu Gln Glu Arg Asn 
        355                 360                 365             


Arg Lys Ile Glu Asp Thr Leu Thr Val Phe Thr Arg Leu Asn Glu Ile 
    370                 375                 380                 


Thr Glu Asp Glu Ile Glu Ser Ser Trp Lys Thr Glu Asp Thr Asp Asn 
385                 390                 395                 400 


Glu His Ile Gly Ile Lys Gln Tyr Ser Pro Lys Tyr Asn Ile Val Gly 
                405                 410                 415     


Asn Arg Ile Ala Ile Lys Ile Leu Pro Glu Glu Ile Thr Asn Asp Ile 
            420                 425                 430         


Glu Thr Thr Ser Ile Val His Pro Lys Ser Thr His Thr Asp Lys Pro 
        435                 440                 445             


Arg His Lys Val Asn His Pro Leu Pro Thr Ala Ile Leu Ser Val His 
    450                 455                 460                 


Glu Leu Gln Asn Leu Phe Leu Phe Arg His Leu His Asn Glu Glu Asn 
465                 470                 475                 480 


Ala Thr Glu Asn Phe Ile Glu Thr Tyr Ile Lys Arg Phe Arg Asp Phe 
                485                 490                 495     


Cys Gln Glu Val Asn Glu Gly Asp Phe Leu Pro Val Ser Asn Phe Leu 
            500                 505                 510         


Asp Cys Leu Val Ser Lys Lys Ser Lys Asp Gln Asp Lys Ala Ala Arg 
        515                 520                 525             


Lys Thr Ala Leu Gln Ala Lys Leu Lys Ala Lys Lys Leu His Ile Asn 
    530                 535                 540                 


Asp Leu Pro Asp Gln Met Arg Asp Tyr Leu Met Gly Tyr Thr Gln Asp 
545                 550                 555                 560 


Asn His Ser Asn Gln Leu Lys Ala Lys Leu Lys Ala Lys Ile Ile Glu 
                565                 570                 575     


Thr Glu Ala Leu Leu Ser Asn Ala Lys Arg Gly Lys Asp Ala Gln Gly 
            580                 585                 590         


Arg Asp Leu Lys Asp Gly Arg Met Ala Thr Tyr Ile Ala Arg Asp Leu 
        595                 600                 605             


Ile Phe Phe Lys Lys Lys Asn Asn Ser Gly Gly Lys Ala Asn Asn Glu 
    610                 615                 620                 


Gln Tyr Asn Glu Leu Gln Lys Ala Ile Ala Leu Phe Pro Ser His Lys 
625                 630                 635                 640 


Gly Lys Leu Gly Gln Tyr Phe Lys Asp Leu Asn Leu Leu Asp Ser Ser 
                645                 650                 655     


Thr Gly His Gln Phe Leu His Glu Ile Pro Trp Ser Tyr Cys Val Asp 
            660                 665                 670         


Thr Ala Asp Phe Tyr Thr Asp Tyr Leu Glu Gly Lys Lys Thr Trp Leu 
        675                 680                 685             


Glu Ser Cys Arg Arg Lys Leu Ser Ser Lys Gln Ala Asp Ile Gln Gln 
    690                 695                 700                 


Phe Phe Lys Leu Lys Lys Thr Asp Ser Lys Asn Leu Asn Tyr Arg Phe 
705                 710                 715                 720 


Thr Val Asn Gln Asn Ser Met Thr Glu Glu Pro Ala Pro Ile Tyr Leu 
                725                 730                 735     


Pro Arg Gly Leu Phe Asn Gly Ala Ile Arg Lys Ala Met Lys Asn Gln 
            740                 745                 750         


Gly Phe Asp Val Asn Lys Glu Thr Ser Ile Thr Lys Cys Phe Glu Leu 
        755                 760                 765             


Ile Ser Lys Gln Asp Thr Gln Thr Phe Tyr Thr His Pro Arg Thr Tyr 
    770                 775                 780                 


Tyr Asp Gly Ile Val Ile Thr Gly Lys Asp Asp Met Lys Ala Val Lys 
785                 790                 795                 800 


Ala Asp Ile Gln Gln Lys Thr Glu Gln Thr Lys Thr Lys Leu Lys Arg 
                805                 810                 815     


Ile Lys Asn Lys Lys Ser Glu Asp Ala Lys Lys Leu Gln Tyr Lys Ile 
            820                 825                 830         


Asn Asp Leu Asn Lys Leu Pro Lys Glu Ile Tyr Arg Asn Glu Leu Lys 
        835                 840                 845             


Ile Arg Phe Ile Gln Ala Asn Asp Arg Ala Ala Phe Met Met Ile Gln 
    850                 855                 860                 


Glu Met Leu Glu Ala Lys Ile Lys Ala Asp Gln Val Gln Leu Arg Ala 
865                 870                 875                 880 


Pro Asp Ser Asp Thr Ser Lys Trp Gln Leu Arg Lys Val Gly Phe Asp 
                885                 890                 895     


Val Lys Asp Asn Ile Leu Asp Gln Lys His Leu Met Gln His Thr Tyr 
            900                 905                 910         


Lys Leu Glu Tyr Lys Asp Lys Asn Asn Ser Asn Asn Asp Glu Tyr Phe 
        915                 920                 925             


Gly Ser Arg Thr Ile Gln Ala Leu Leu Pro Phe Lys Gln Tyr Gly Lys 
    930                 935                 940                 


Phe Arg Arg Phe Leu Lys Asp Lys Arg Leu Trp Ser Thr Arg Thr Lys 
945                 950                 955                 960 


Asp Gly Leu Arg Leu Pro Gln Gly Leu Leu Ser Tyr Tyr Ser Glu Gly 
                965                 970                 975     


Asp Val Ile Glu Leu Glu Thr Ile Arg Arg Glu Phe Val Asn Phe Asp 
            980                 985                 990         


Thr Lys Cys Tyr Glu Glu Thr Leu  Leu His Ile Tyr Asp  Phe Glu Ser 
        995                 1000                 1005             


Ile Leu  His Gln Glu Phe Gln  Thr Glu Phe Asn Glu  Lys Ile Arg 
    1010                 1015                 1020             


Asn Lys  Lys Ser Leu Arg His  Gly Asp Gln Leu Ala  Leu Val Gln 
    1025                 1030                 1035             


Thr Lys  Ile Leu Asn Asn Thr  Ser Val Leu Thr Asn  Pro Asp Lys 
    1040                 1045                 1050             


Asp Asp  Thr Ala Ile Met Arg  Asn Lys Ile Phe His  His Gln Ile 
    1055                 1060                 1065             


Pro Asn  Asn Asp Trp Leu Thr  Gln Lys Val Ile Val  Tyr Lys Gly 
    1070                 1075                 1080             


Leu Glu  Ala Asn Arg Lys Lys  Gln Asp Glu Asp Asn  Pro Phe Ile 
    1085                 1090                 1095             


Thr Gln  Gln Ile Phe Val Gly  Ile Gln Thr Val Tyr  Lys Asp Leu 
    1100                 1105                 1110             


Thr Gln  Arg Met Lys Ile Arg  Met Asn Gln Pro 
    1115                 1120                 


<210>  2751
<211>  994
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2751

Met Asp Ser Lys Tyr Ile Leu Gly Ser Tyr Leu Asn Met Ala Asn Asp 
1               5                   10                  15      


Asn Phe Ile Asn Thr Ile His Leu Leu Ala Lys Lys Leu Lys Thr Pro 
            20                  25                  30          


Lys Gly Glu Asp Gln Asn Leu Asp Gln Val Val Ser Tyr Ile Thr Arg 
        35                  40                  45              


Ile Phe Asp Asn Ser Asn Gln Val Pro Glu Thr Glu Gln Ile Val Glu 
    50                  55                  60                  


Phe Tyr Phe Pro Trp Leu Glu Ala Leu Lys Asn Ala Asn Gly Phe Gly 
65                  70                  75                  80  


Lys Ser Glu Leu Pro Glu Leu Lys Ile Phe Tyr Lys Asp Val Leu Cys 
                85                  90                  95      


Ser Phe Ala Glu Asn Leu Lys Asp Leu Arg Asn Asn Tyr Thr His Tyr 
            100                 105                 110         


Ile His Lys Thr Ile Ser Tyr His Pro Ile Ile Tyr Lys Lys Glu Gly 
        115                 120                 125             


Asn Thr Leu Gln Ser Ser Leu Pro Lys Ala Leu Leu Gln Ile Tyr Asp 
    130                 135                 140                 


Ala Ser Ile Lys Leu Ala Lys Glu Arg Phe Ser Ala Asp Glu Asn Ala 
145                 150                 155                 160 


Val Thr His Leu Arg Arg Tyr Lys Ile Val Gly Lys Lys Val Val Arg 
                165                 170                 175     


Lys Thr Glu Ala Asp His Phe Met Tyr Leu Leu Glu Lys Asp His Leu 
            180                 185                 190         


Leu Thr Glu Lys Gly Ile Ala Phe Phe Thr Ser Leu Phe Leu Asn Arg 
        195                 200                 205             


Lys Tyr Gly Tyr Leu Met Leu Lys Gln Leu Lys Gly Phe Lys Gln Gly 
    210                 215                 220                 


Gly Thr Leu Ala Tyr Arg Leu Thr Leu Glu Thr Phe Leu Ala Tyr Ser 
225                 230                 235                 240 


Asn Ile Lys Pro Val Glu Arg Leu Lys Ala Asp Lys Tyr Ser Asp Val 
                245                 250                 255     


Ala Phe Ile Met Asp Leu Leu Gly Glu Ile Ser Lys Ile Pro Lys Glu 
            260                 265                 270         


Leu Tyr His Ile Leu Pro Glu Thr Tyr Ile Leu Gln Tyr Lys Asn Lys 
        275                 280                 285             


Leu His Ile Glu Leu Asn Glu Asp Ile Ser Leu Glu Ala Tyr Cys Ser 
    290                 295                 300                 


Arg Gly Arg Asn Arg Phe Asp Gln Leu Ala Leu Thr Tyr Leu Asp Arg 
305                 310                 315                 320 


Leu Glu Asp Phe Lys Gln Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr 
                325                 330                 335     


Ile His Asn Gly Tyr Met Lys Ala Arg Ile Asp Gly Thr Glu Gln Glu 
            340                 345                 350         


Arg Tyr Leu Ser Glu Lys Met Tyr Gly Cys Cys Lys Asn Ile Tyr Arg 
        355                 360                 365             


Asp Leu Ser Ala Ile Val Ala Lys Gln Tyr Asn Ile Glu Val Lys Asp 
    370                 375                 380                 


Ser Thr Glu Thr Ser Tyr Met Leu Pro Asn Asp Phe Gln Pro His Val 
385                 390                 395                 400 


Ile Arg Ala Tyr Pro His Tyr Val Ile Asn Asn Asn Asn Ile Gly Ile 
                405                 410                 415     


Arg Leu Leu Asp Glu Gly Glu Ser Gly Phe Pro Ile Leu Glu Asn Arg 
            420                 425                 430         


Gly Thr Lys Asn Val Val Pro His Phe Trp Met Ser Lys Tyr Asp Leu 
        435                 440                 445             


Pro Ala Leu Leu Phe Tyr Ala Tyr Leu Arg Ser Asp Ser Arg Phe Ala 
    450                 455                 460                 


Ser Lys Cys Lys Lys Thr Ile Asp Glu Ile Leu Arg Gly Tyr Leu Ser 
465                 470                 475                 480 


Lys Ser Lys Asp Lys Lys Pro Lys Gln Ala Glu Lys Ala Ser Val Leu 
                485                 490                 495     


Met Leu Arg Arg Ile Asp Lys Ala Ile Ile Trp Thr Gln Thr Lys Leu 
            500                 505                 510         


Asn Glu Ala Glu Lys Gln Arg Asp Asn Lys Lys Ser Phe Lys Ile Gly 
        515                 520                 525             


Glu Lys Ala Asp Ile Leu Ala His Asp Met Leu Trp Leu Gln Pro Ala 
    530                 535                 540                 


Lys Glu Ser Lys Asp Lys Val Ser Gly Ala Asn Phe Arg Ala Leu Gln 
545                 550                 555                 560 


Thr Ser Leu Ala Phe Phe Lys Arg Asn Glu Leu Glu Asp Ile Phe Lys 
                565                 570                 575     


Arg Ser Phe Leu Ile Gly Gly Asn Asn Pro His Pro Phe Leu Ser Arg 
            580                 585                 590         


Ile Lys Ile Asn Thr Met Pro Ser Leu Phe Asp Phe Tyr Leu Ala Tyr 
        595                 600                 605             


Met Arg Glu Arg Leu Asn Tyr Leu Gly Lys Ile Lys Leu Lys Leu Leu 
    610                 615                 620                 


Lys Gly His Ile Asn Val Ser Cys His Pro Leu Arg Lys Leu Asn His 
625                 630                 635                 640 


Glu Lys Leu Val Asp Gln Asp Asn Lys Lys Asp Glu Gln Pro Ile Phe 
                645                 650                 655     


Leu Pro Arg Gly Ile Phe Asn Asp Val Ile Lys Asn Cys Leu Gln Lys 
            660                 665                 670         


Thr Lys Leu Gly Ile Tyr Leu Lys Asp Gln Gly Ala Glu Thr Arg Ser 
        675                 680                 685             


Trp Asn Val Ala Tyr Gln Ile Leu Lys Phe His Glu Ile Ile Asn Asp 
    690                 695                 700                 


Asp Asp Ile Gln Glu Phe Tyr Lys Gln Pro Arg Lys Tyr Ala Ile Leu 
705                 710                 715                 720 


Asp Glu Asn His Tyr Leu Thr Leu Glu Glu Arg Thr Asp Arg Leu Lys 
                725                 730                 735     


Asp Leu Lys Pro Glu Cys Ile Glu Val Ser Lys Ala Asn Asp Ile Leu 
            740                 745                 750         


Glu Lys Glu Asp Tyr Leu Leu Arg Lys Ser Tyr Asn Gln Val Cys Asp 
        755                 760                 765             


Asn Glu Ser Ala Ile Arg Leu Tyr Gln Val Gln Asp Ile Leu Leu Phe 
    770                 775                 780                 


Met Ile Ala Gln Arg Leu Cys Asn Glu Ile Ile Leu Gly Asp Lys Gln 
785                 790                 795                 800 


Glu Lys Lys Glu Lys Val Glu Thr Ser Phe Ser Leu Thr Leu Lys Asn 
                805                 810                 815     


Leu Ser Lys Lys Phe Asp Gln Pro Val His Phe Glu Ile Lys Met Thr 
            820                 825                 830         


Asn Val Asn Leu Phe Ser Asp Thr Asp Ile Pro Val Lys Asn Phe Gly 
        835                 840                 845             


Lys Met Leu Arg Leu Lys Lys Asp Ala Arg Phe Ile Ser Tyr Asn Lys 
    850                 855                 860                 


Leu Phe Asn Cys Gln Lys Gln Asn Ile Asn Tyr Asn Asp Tyr Cys Lys 
865                 870                 875                 880 


Glu Glu Glu Tyr Phe Asp Ile Cys Arg Ile Gln Thr Ile Lys Leu Cys 
                885                 890                 895     


His Glu Leu Glu Glu Lys Leu Leu Glu Lys Gly Ile Ile Thr Glu Ser 
            900                 905                 910         


Pro Asp Ser Gly Tyr Tyr Pro Phe Ala Asp Leu Val Gln Arg Ile Ile 
        915                 920                 925             


Asn Gln Gly Val Val Ile Cys Ser Ser Asp Val Lys Phe Ile Leu Glu 
    930                 935                 940                 


Ala Arg Asn Thr Phe Leu His Asn Glu Tyr Lys Gln Cys Cys Val Asn 
945                 950                 955                 960 


Ser Ile Asn Ser Ile Asp Ser Phe Ile Ala Glu Lys Val Tyr Asn Leu 
                965                 970                 975     


Phe Lys Gln Lys Met Asp Asn Ile Leu Gly Gln Leu Glu Ser Ile Lys 
            980                 985                 990         


Pro Ser 
        


<210>  2752
<211>  976
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2752

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Pro Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Thr 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


<210>  2753
<211>  994
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2753

Met Asp Ser Lys Tyr Ile Leu Gly Ser Tyr Leu Asn Met Ala Asn Asp 
1               5                   10                  15      


Asn Phe Ile Asn Thr Ile His Leu Leu Ala Lys Lys Leu Lys Thr Pro 
            20                  25                  30          


Lys Gly Glu Asp Gln Asn Leu Asp Gln Val Val Ser Tyr Ile Pro Arg 
        35                  40                  45              


Ile Phe Asp Asn Ser Asn Gln Val Pro Glu Thr Glu Gln Ile Val Glu 
    50                  55                  60                  


Phe Tyr Phe Pro Trp Leu Glu Ala Leu Lys Asn Ala Asn Gly Phe Gly 
65                  70                  75                  80  


Lys Ser Glu Leu Pro Glu Leu Lys Ile Phe Tyr Lys Asp Val Leu Cys 
                85                  90                  95      


Ser Phe Ala Glu Asn Leu Lys Asp Leu Arg Asn Asn Tyr Thr His Tyr 
            100                 105                 110         


Ile His Lys Thr Ile Ser Tyr His Pro Ile Ile Tyr Lys Lys Glu Gly 
        115                 120                 125             


Asn Thr Leu Gln Cys Ser Leu Pro Lys Ala Leu Leu Gln Ile Tyr Asp 
    130                 135                 140                 


Thr Ser Ile Lys Leu Ala Lys Glu Arg Phe Ser Ala Asp Glu Asn Ala 
145                 150                 155                 160 


Val Thr His Leu Arg Arg Tyr Lys Met Val Gly Lys Lys Val Val Arg 
                165                 170                 175     


Lys Thr Glu Ala Asp His Phe Met Tyr Ser Leu Glu Lys Asp His Leu 
            180                 185                 190         


Leu Thr Glu Lys Gly Ile Ala Phe Phe Thr Ser Leu Phe Leu Asn Arg 
        195                 200                 205             


Lys Tyr Gly Tyr Leu Met Leu Lys Gln Leu Lys Gly Phe Lys Gln Gly 
    210                 215                 220                 


Gly Thr Leu Ala Tyr Arg Leu Thr Leu Glu Thr Phe Leu Ala Tyr Ser 
225                 230                 235                 240 


Asn Ile Lys Pro Val Glu Arg Leu Lys Ala Asp Lys Tyr Ser Asp Val 
                245                 250                 255     


Ala Phe Ile Met Asp Leu Leu Gly Glu Ile Ser Lys Ile Pro Lys Glu 
            260                 265                 270         


Leu Tyr His Ile Leu Pro Glu Thr Tyr Ile Leu Gln Tyr Lys Asn Lys 
        275                 280                 285             


Leu His Ile Glu Leu Asn Glu Asp Ile Ser Leu Glu Ala Tyr Cys Ser 
    290                 295                 300                 


Arg Gly Arg Asn Arg Phe Asp Gln Leu Ala Leu Thr Tyr Leu Asp Arg 
305                 310                 315                 320 


Leu Glu Asp Phe Lys Gln Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr 
                325                 330                 335     


Ile His Asn Gly Tyr Met Lys Val Arg Ile Asp Gly Thr Glu Gln Glu 
            340                 345                 350         


Arg Tyr Leu Ser Glu Lys Met Tyr Gly Cys Cys Lys Asn Ile Tyr Arg 
        355                 360                 365             


Asp Leu Ser Ala Ile Val Ala Lys Gln Tyr Asn Ile Lys Val Lys Asp 
    370                 375                 380                 


Ser Thr Glu Thr Ser Tyr Met Leu Pro Asn Asp Phe Gln Pro His Val 
385                 390                 395                 400 


Ile Arg Ala Tyr Pro His Tyr Val Ile Asn Asn Asn Asn Ile Gly Ile 
                405                 410                 415     


Arg Leu Leu Asp Glu Gly Glu Ser Gly Phe Pro Ile Leu Glu Asn Arg 
            420                 425                 430         


Gly Thr Lys Asn Val Val Pro His Phe Trp Met Ser Lys Tyr Asp Leu 
        435                 440                 445             


Pro Ala Leu Leu Phe Tyr Ala Tyr Leu Arg Ser Asp Ser Arg Phe Ala 
    450                 455                 460                 


Ser Lys Cys Lys Lys Thr Ile Asp Glu Ile Leu Arg Gly Tyr Leu Ser 
465                 470                 475                 480 


Lys Ser Lys Asp Lys Lys Pro Lys Gln Ala Glu Lys Val Ser Val Leu 
                485                 490                 495     


Met Leu Arg Arg Ile Asp Lys Ala Ile Ile Trp Thr Gln Thr Lys Leu 
            500                 505                 510         


Asn Glu Ala Glu Lys Gln Arg Asp Asn Lys Lys Ser Phe Lys Ile Gly 
        515                 520                 525             


Glu Lys Ala Asp Ile Leu Ala His Asp Met Leu Trp Leu Gln Pro Ala 
    530                 535                 540                 


Lys Glu Ser Lys Asp Lys Val Ser Gly Ala Asn Phe Arg Ala Leu Gln 
545                 550                 555                 560 


Thr Ser Leu Ala Phe Phe Lys Arg Asn Glu Leu Glu Asp Ile Phe Lys 
                565                 570                 575     


Arg Ser Phe Leu Ile Gly Gly Asn Asn Pro His Pro Phe Leu Ser Arg 
            580                 585                 590         


Ile Lys Ile Asn Thr Met Pro Ser Leu Phe Asp Phe Tyr Leu Ala Tyr 
        595                 600                 605             


Met Arg Glu Arg Leu Asn Tyr Trp Glu Lys Ile Lys Leu Lys Leu Leu 
    610                 615                 620                 


Lys Gly His Ile Asn Val Ser Cys His Pro Leu Arg Lys Leu Asn His 
625                 630                 635                 640 


Gly Lys Pro Val Asp Gln Asp Asn Lys Lys Asp Glu Gln Pro Ile Phe 
                645                 650                 655     


Leu Pro Arg Gly Ile Phe Asn Asp Val Ile Lys Asn Cys Leu Gln Lys 
            660                 665                 670         


Thr Lys Leu Gly Ile Tyr Leu Lys Asp Gln Gly Val Glu Thr Arg Ser 
        675                 680                 685             


Trp Asn Val Ala Tyr Gln Ile Leu Lys Phe His Glu Ile Ile Asn Asp 
    690                 695                 700                 


Asp Asp Ile Gln Glu Phe Tyr Lys Gln Pro Arg Lys Tyr Ala Ile Leu 
705                 710                 715                 720 


Asp Glu Asn His Tyr Leu Thr Leu Glu Glu Arg Thr Asp Arg Leu Lys 
                725                 730                 735     


Asp Leu Lys Pro Glu Cys Ile Glu Val Ser Lys Ala Asn Asp Ile Leu 
            740                 745                 750         


Glu Lys Glu Asp Tyr Leu Leu Arg Lys Ser Tyr Asn Gln Val Cys Asp 
        755                 760                 765             


Asn Glu Ser Ala Ile Arg Leu Tyr Gln Val Gln Asp Ile Leu Leu Phe 
    770                 775                 780                 


Met Ile Ala Gln Arg Leu Cys Asn Glu Ile Ile Leu Gly Asp Lys Gln 
785                 790                 795                 800 


Glu Lys Lys Glu Lys Ile Val Thr Ser Phe Ser Leu Thr Leu Lys Asn 
                805                 810                 815     


Leu Ser Lys Lys Phe Asp Gln Pro Val His Phe Glu Ile Lys Met Asn 
            820                 825                 830         


Asn Val Asp Leu Phe Ser Asp Thr Asp Phe Pro Val Lys Asn Phe Gly 
        835                 840                 845             


Lys Met Leu Arg Leu Lys Lys Asp Ala Arg Phe Ile Ser Tyr Asp Lys 
    850                 855                 860                 


Leu Phe Lys Gly Gln Lys Gln Asn Ile Asn Tyr Asn Asp Tyr Cys Lys 
865                 870                 875                 880 


Glu Glu Glu Tyr Phe Asp Ile Cys Arg Ile Gln Met Val Lys Leu Cys 
                885                 890                 895     


His Glu Leu Glu Glu Lys Leu Leu Glu Lys Gly Ile Ile Thr Glu Ser 
            900                 905                 910         


Pro Asn Ser Gly Tyr Tyr Pro Phe Ala Asp Leu Val Gln Arg Ile Ile 
        915                 920                 925             


Asn Gln Gly Val Val Ile Ser Ser Ser Asp Val Lys Phe Ile Leu Glu 
    930                 935                 940                 


Ala Arg Asn Met Phe Leu His Asn Glu Tyr Lys Gln Tyr Cys Val Asn 
945                 950                 955                 960 


Ser Ile Asn Ser Ile Asp Ser Phe Ile Ala Glu Lys Val Tyr Asn Leu 
                965                 970                 975     


Phe Lys Gln Lys Met Asp Asn Ile Leu Gly Gln Leu Glu Ser Ile Lys 
            980                 985                 990         


Pro Ser 
        


<210>  2754
<211>  1131
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2754

Met Glu Lys Thr Ile Glu Asn Gln Thr Gln Ser Lys Arg Thr Leu Asn 
1               5                   10                  15      


Asn Thr Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Asp Glu Glu Lys Ile Thr Thr Ser Phe Leu Val Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Arg Gln Ser Leu Val Tyr Ser Asn Leu Thr 
65                  70                  75                  80  


Arg Tyr Met His Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Asp 
                85                  90                  95      


Asp Glu Arg Asp Lys Ala Glu Asn Tyr Gly Lys Asp Phe Gly Asn Leu 
            100                 105                 110         


Thr Asp Thr Leu Lys Glu Ile Phe Lys Glu Leu Asn Glu Phe Arg Asn 
        115                 120                 125             


Asp Tyr Ser His Tyr Tyr Ser Thr Glu Lys Lys Asp Lys Arg Lys Thr 
    130                 135                 140                 


Ile Val Ser Asp Lys Leu Lys Asn Phe Leu Asn Ile Asn Tyr Thr Arg 
145                 150                 155                 160 


Ala Ile Lys Tyr Thr Lys Ser Arg Phe Ile Asn Val Phe Ser Asp Asn 
                165                 170                 175     


Asn Phe Cys Leu Ala Glu Glu Ala Lys His Val Glu Asn Asp Asn Thr 
            180                 185                 190         


Ile Thr Gln Asp Gly Ile Val Phe Phe Thr Ser Met Phe Leu Asp Arg 
        195                 200                 205             


Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile Ile Gly Leu Lys Gly Thr 
    210                 215                 220                 


Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Thr Leu Met Ala Phe Cys 
225                 230                 235                 240 


Val Asn Leu Pro His Asp Lys Phe Val Ser Glu Asn Ser Glu Gln Gln 
                245                 250                 255     


Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu 
            260                 265                 270         


Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln His Phe Leu Pro Lys Leu 
        275                 280                 285             


Asp Asp Glu Gln Ile Asp Asn Val Leu Glu Asn Ser Val Pro Tyr Thr 
    290                 295                 300                 


Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn Ile Thr Lys Lys Val Arg 
305                 310                 315                 320 


Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu Lys Phe Ile Asp Gln Lys 
                325                 330                 335     


Lys Leu Phe Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val 
            340                 345                 350         


Leu Asp Glu Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Lys Arg Thr 
        355                 360                 365             


Val Thr Glu Asn Thr Lys Ala Phe Gly Met Leu Gln Asp Leu Asn Asp 
    370                 375                 380                 


Glu Glu Asn Val Leu Asn Lys Ile Asn Thr Gly Glu Ser Lys Ala Lys 
385                 390                 395                 400 


Phe Asp Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Thr Lys Asn 
            420                 425                 430         


Thr Asp Asn Lys Ile Lys Ser Asn Leu Leu Gln Pro Leu Pro Glu Ala 
        435                 440                 445             


Phe Leu Ser Ile Asn Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
    450                 455                 460                 


Glu Gln Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn 
465                 470                 475                 480 


Asn Ser Lys Ile Leu Asn Lys Glu Phe Ile Lys Ala Ile Lys Leu Lys 
                485                 490                 495     


Leu Asn Asp Leu Asp Val Phe Tyr Lys Arg Ser Gln Gly Arg Lys Gln 
            500                 505                 510         


Lys His Ala Tyr Leu Thr Lys Asp Lys Lys Tyr Asp Asn Glu Lys Ile 
        515                 520                 525             


Asn Glu Leu Lys Asn Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu 
    530                 535                 540                 


Tyr Asn Leu Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp 
545                 550                 555                 560 


Leu Asn Ile Ala Asp Val Gln Ala Lys Asn Ala Ile Ser Asp Arg Ile 
                565                 570                 575     


Lys Leu Met Lys Arg Asp Cys Ile Asn Arg Leu Lys Ser Met Lys Lys 
            580                 585                 590         


Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp 
        595                 600                 605             


Ile Val Asp Met Ile Ile Asp Glu Glu Lys Lys Lys Lys Ile Thr Ser 
    610                 615                 620                 


Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Lys 
625                 630                 635                 640 


Glu Lys Lys Glu Leu Phe Ile Leu Ile Cys Asn Asn Glu Leu Lys Leu 
                645                 650                 655     


Asn Asp Asp Asp Gly His Pro Phe Phe Lys Asn Ile Asn Phe Ser Asn 
            660                 665                 670         


Tyr Lys Tyr Thr Ser Glu Ile Tyr Gln Lys Tyr Leu Glu Glu Lys Gly 
        675                 680                 685             


His Lys Met Val Lys Glu Tyr Asn Pro Arg Lys Glu Asn Tyr Val Glu 
    690                 695                 700                 


Lys Asp Lys Ser Trp Leu Glu Ile Asn Phe Tyr Lys Lys Glu Trp Asn 
705                 710                 715                 720 


Glu Asn Ala Lys Lys Asp Leu Thr Val Val Lys Leu Pro Asp Asp Lys 
                725                 730                 735     


Ser Lys Ile Pro Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser 
            740                 745                 750         


Phe Glu Asn Trp Phe Lys Tyr Val Thr Asn Gly Lys Glu Thr Thr Asp 
        755                 760                 765             


Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp Glu Thr Leu 
    770                 775                 780                 


Lys Glu Leu Leu Lys Lys Glu Leu Ser Lys Asn Asn Ile Glu Phe Lys 
785                 790                 795                 800 


Glu Glu Asp Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Asp Lys Cys 
                805                 810                 815     


Arg Asn Asp Lys Thr Gln Lys Phe Tyr Ser Ala Glu Arg Glu Tyr Thr 
            820                 825                 830         


Phe Glu Glu Glu Lys Leu Asn Phe His Ile Asn Thr Lys Ser Lys Phe 
        835                 840                 845             


Glu Glu Tyr Ile Asn Pro Glu Phe Ala Glu Lys Val Phe Arg Leu Lys 
    850                 855                 860                 


Asn Gln Asn Arg Glu Lys Asp Asn Ile Ser Gly Arg Arg Leu Pro Pro 
865                 870                 875                 880 


Leu Lys Met Lys Glu Val Thr Lys Asn Met Val Lys Arg Ile Gly Asn 
                885                 890                 895     


Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Leu Met Leu 
            900                 905                 910         


Leu Met Phe Glu Lys Leu Val Asp Asn Asn Leu Lys Leu Lys Leu Glu 
        915                 920                 925             


Asn Val Asp Lys Leu Leu Asn Glu Ser Ile Glu Ile Asn Gln Ser Ile 
    930                 935                 940                 


Ser Gly Lys Leu Ser Phe Asp Asp Ser Gly Asp Asn Glu Asn Lys Lys 
945                 950                 955                 960 


Asp Arg Ala Ile Ile Cys Arg Asn Ile Thr Glu Thr Arg Lys Arg Lys 
                965                 970                 975     


Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Glu Glu Glu  Asn Ile Pro Ile Glu  Lys Ile Lys 
        995                 1000                 1005             


Ile Glu  Leu Asp Thr Tyr Ser  Lys Ala Lys Asp Val  Val Phe Asp 
    1010                 1015                 1020             


Leu Ile  Phe Asp Leu Glu Arg  Ala Ile Ile Asn Lys  Asp Glu Asn 
    1025                 1030                 1035             


Arg Ile  Lys Glu Leu Asn Lys  Asp Lys Asn Gly Val  Ile Gln Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Phe Trp Leu  Leu Glu Lys 
    1055                 1060                 1065             


Asn Leu  Ile Thr Glu Gln Glu  Phe Thr Phe Met Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Thr  Phe Ser His Asn Gln  Phe Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Leu Phe  Ile Lys Asn Trp Asn  Glu Asn Glu Phe Ala  Lys Gln Ile 
    1100                 1105                 1110             


Leu Asn  Val Tyr Asn Gln Lys  Asn Asn Asn Leu Ile  Lys Ser Ile 
    1115                 1120                 1125             


Lys Asp  Ile 
    1130     


<210>  2755
<211>  908
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2755

Met Glu Thr Leu Thr Ile Pro Glu Val Ile Lys Cys Arg Thr Leu Ser 
1               5                   10                  15      


Asp Asp Pro Gln Phe Phe Gly Gly Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Val Phe Asn Ile Ser Asn His Ile Ala Lys Glu Phe Asp Leu Pro Leu 
        35                  40                  45              


Leu Ala Glu Glu Asp His Leu Arg Asn Ser Phe Leu Cys Asn Lys Glu 
    50                  55                  60                  


Asn Lys Lys Ile Asn Trp Asn His Leu Tyr Ser Arg Thr Asn Arg Phe 
65                  70                  75                  80  


Leu Ser Val Leu Lys Val Phe Asp Ala Glu Ser Leu Pro Lys Glu Glu 
                85                  90                  95      


Gln Lys Thr Thr Asn Leu Glu Gly Lys Asp Phe Ala Leu Met Ser Asp 
            100                 105                 110         


Thr Leu Lys Ile Val Phe Gly Glu Leu Gln Asp Phe Arg Asn Asp Tyr 
        115                 120                 125             


Ser His Tyr Tyr Ser Thr Glu Lys Gly Thr Ile Arg Lys Thr Thr Val 
    130                 135                 140                 


Ser Asp Glu Met Ala Leu Phe Leu Lys Val Asn Phe Asn Arg Ala Ile 
145                 150                 155                 160 


Glu Tyr Thr Lys Glu Arg Phe Lys Gly Val Leu Asn Glu Glu Asp Phe 
                165                 170                 175     


Gln Leu Val Ala Ser Lys Lys Val Met Glu Ala Asn Leu Thr Ile Thr 
            180                 185                 190         


Thr Glu Gly Leu Val Cys Leu Ile Ser Met Phe Leu Glu Arg Glu Tyr 
        195                 200                 205             


Ala Phe Gln Phe Ile Gly Lys Ile Thr Gly Leu Lys Gly Thr Glu Asn 
    210                 215                 220                 


Lys Ser Phe Ile Ala Thr Arg Glu Val Leu Met Ala Phe Cys Leu Lys 
225                 230                 235                 240 


Leu Pro His Asp Arg Phe Gln Ser Asp Asn Thr Arg Gln Ala Phe Ser 
                245                 250                 255     


Leu Asp Leu Ile Asn Glu Leu Asn Arg Cys Pro Lys Val Leu Tyr Asn 
            260                 265                 270         


Ser Ile Thr Ala Ser Gly Lys Gln Ile Phe Gln Pro Lys Leu Asp Ile 
        275                 280                 285             


Leu Gly Ile Lys Asn Leu Leu Asp Asn Ser Thr Asn Ile Asp Glu Glu 
    290                 295                 300                 


Val Glu Asp Tyr Asp Glu Tyr Ile Glu Ala Leu Thr Lys Arg Ile Arg 
305                 310                 315                 320 


His Ser Asn Arg Phe Ser Asp Phe Ala Leu Lys Tyr Ile Asp Glu Thr 
                325                 330                 335     


Gly Ile Phe Asp Lys Phe Arg Phe Gln Ile Asp Leu Gly Lys Leu Leu 
            340                 345                 350         


Val Asp Glu Tyr Ala Lys Phe Phe Asn Ser Glu Glu Val Pro Arg Arg 
        355                 360                 365             


Ile Ile Glu Asn Val Lys Ala Phe Gly Lys Leu Asn Ser Phe Asn Asp 
    370                 375                 380                 


Glu Ala Lys Val Leu Thr Arg Ile Gly Asn Gly Tyr Pro Ser Lys Glu 
385                 390                 395                 400 


Phe Glu Gln Phe Ser Pro His Tyr Asn Thr Glu Asn Asn Lys Ile Gly 
                405                 410                 415     


Ile Ser Val Lys Glu Asp Thr Ala Lys Leu Arg Pro Asn Ser Lys Gly 
            420                 425                 430         


Glu Thr Gly Lys Lys Leu His Gln Pro Leu Pro Glu Ala Phe Leu Ser 
        435                 440                 445             


Leu His Glu Leu Pro Lys Val Ile Ile Leu Asp Tyr Leu Gln Lys Gly 
    450                 455                 460                 


Glu Pro Glu Arg Leu Ile Glu Asp Phe Ile Leu Ile Asn Asn Ser Lys 
465                 470                 475                 480 


Leu Met Thr Met Pro Phe Ile Glu Ala Val Lys Ser Gln Met Pro Lys 
                485                 490                 495     


Glu Trp Asp Asp Phe Arg Arg Arg Thr Asp Thr Lys Lys Glu Met Ala 
            500                 505                 510         


Tyr Asn Glu Lys Thr Leu Thr Tyr Leu Leu Glu Arg Lys Asn Thr Leu 
        515                 520                 525             


Asn Gln Val Leu Ala Glu Tyr Gln Leu Asn Asp Lys Gln Ile Pro Gly 
    530                 535                 540                 


Arg Ile Leu Asp Tyr Trp Leu Asn Ile Lys Asp Val Glu Glu Gly Arg 
545                 550                 555                 560 


Ala Val Ser Asp Arg Ile Lys Ser Ile Lys Arg Asp Cys Met Ser Arg 
                565                 570                 575     


Leu Arg Ala Leu Glu Lys Phe Lys Ile Asp Arg Asn Arg Asn Lys Ile 
            580                 585                 590         


Pro Lys Ile Gly Glu Met Ala Thr Phe Leu Ala Lys Asp Ile Val Asp 
        595                 600                 605             


Met Val Ala Gly Glu Glu Lys Lys Gln Lys Ile Thr Ser Phe Tyr Tyr 
    610                 615                 620                 


Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Ser Asp Lys Lys 
625                 630                 635                 640 


Gln Leu Phe Ile His Thr Val Cys Asn Glu Leu Arg Leu Asn Glu Thr 
                645                 650                 655     


Gly Gly His Pro Phe Leu Tyr Lys Leu Asp Leu Gln His Ile Asn Ser 
            660                 665                 670         


Thr Ser Glu Phe Tyr Gly Lys Tyr Leu Gln Glu Lys Gly His Lys Met 
        675                 680                 685             


Val Arg Glu Lys Asn Leu Arg Thr Gly Arg Val Ala Glu Val Asp Gln 
    690                 695                 700                 


Ser Trp Met Ala Thr Thr Phe Tyr Lys Lys Glu Trp Asn Glu Lys Ile 
705                 710                 715                 720 


Gly Lys Gln Leu Thr Val Val Lys Leu Pro Leu Asn Lys Ser Lys Ile 
                725                 730                 735     


Pro Phe Thr Leu Arg Leu Leu Glu Glu Lys Thr Ile Tyr Thr Leu Asp 
            740                 745                 750         


Gln Trp Leu Gln Asn Leu Thr Lys Gly Arg Asn Pro Asn Asp Ala Lys 
        755                 760                 765             


His Pro Val Asn Leu Pro Thr Asn Leu Phe Asp Glu Arg Leu Thr Val 
    770                 775                 780                 


Leu Leu Arg His Asp Leu Asp Glu Arg Gln Ile Ser Tyr Pro Ser Asn 
785                 790                 795                 800 


Ser Tyr Asp Asn Glu Leu Phe Lys Ile Trp Trp Lys Ser Arg Ser Asp 
                805                 810                 815     


Ser Thr Gln Ser Phe Tyr Asn Ala Glu Arg Glu Tyr Val Ile Phe Gly 
            820                 825                 830         


Glu Lys Val Asn Phe Met Pro Asn Thr Lys Asp Asn Phe Ala Asp Tyr 
        835                 840                 845             


Tyr Gln His Ala Phe Thr Thr Ala Tyr Gln Lys Lys Arg Lys Glu Arg 
    850                 855                 860                 


Thr Leu Gln Gln Lys Glu Asp Arg Arg Leu Pro Asn Ile Gln Leu Glu 
865                 870                 875                 880 


Gln Val Glu Lys Ser Leu Ser Lys Pro Leu Pro Glu Pro Lys Lys Arg 
                885                 890                 895     


Ser Val Cys Cys Arg Lys Lys Thr Ala Ser Cys Cys 
            900                 905             


<210>  2756
<211>  1003
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2756

Met Gly Ala Ile Glu Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Arg Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Glu Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Leu Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Asn Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu Ile Thr Glu Tyr Glu Lys Arg Thr Lys Gln 
    930                 935                 940                 


Lys Ile Asp Ser Ser Phe Leu Ile Lys Thr Arg Asn Met Phe Leu His 
945                 950                 955                 960 


Asp Lys Tyr Glu Ala Glu Cys Ile Lys Glu Ile Ser Asp Asp Phe Val 
                965                 970                 975     


Tyr Ala Lys Lys Ile Ile Ala Glu Phe Lys Met Lys Ile Glu Asn Ile 
            980                 985                 990         


Lys Leu Glu Asp Phe Ser Asn Asp  Ser Ser Ala 
        995                 1000             


<210>  2757
<211>  1115
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2757

Met Thr Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg Leu Asn 
1               5                   10                  15      


Ile Phe Asn Ile Ser Asn His Leu Ala Glu Lys Phe Gly Leu Ala Val 
            20                  25                  30          


Leu Asp Asp Glu Glu Lys Ile Thr Thr Ser Phe Leu Val Asp Lys Gly 
        35                  40                  45              


Asn Lys Glu Tyr Lys Thr Arg Gln Ser Leu Val Tyr Ser Asn Leu Thr 
    50                  55                  60                  


Arg Tyr Met His Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Asp 
65                  70                  75                  80  


Asp Glu Arg Asp Lys Ala Glu Asn Tyr Gly Lys Asp Phe Gly Asn Leu 
                85                  90                  95      


Thr Asp Thr Leu Lys Glu Ile Phe Lys Glu Leu Asn Glu Phe Arg Asn 
            100                 105                 110         


Asp Tyr Ser His Tyr Tyr Ser Thr Glu Lys Lys Asp Lys Arg Lys Thr 
        115                 120                 125             


Ile Val Ser Asp Lys Leu Lys Asn Phe Leu Asn Ile Asn Tyr Thr Arg 
    130                 135                 140                 


Ala Ile Lys Tyr Thr Lys Ser Arg Phe Ile Asn Val Phe Ser Asp Asn 
145                 150                 155                 160 


Asn Phe Cys Leu Ala Glu Glu Ala Lys His Val Glu Asn Asp Asn Thr 
                165                 170                 175     


Ile Thr Gln Asp Gly Ile Val Phe Phe Thr Ser Met Phe Leu Asp Arg 
            180                 185                 190         


Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile Ile Gly Leu Lys Gly Thr 
        195                 200                 205             


Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Thr Leu Met Ala Phe Cys 
    210                 215                 220                 


Val Asn Leu Pro His Asp Lys Phe Val Ser Glu Asn Ser Glu Gln Gln 
225                 230                 235                 240 


Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu 
                245                 250                 255     


Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln His Phe Leu Pro Lys Leu 
            260                 265                 270         


Asp Asp Glu Gln Ile Asp Asn Val Leu Glu Asn Ser Val Pro Tyr Thr 
        275                 280                 285             


Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn Ile Thr Lys Lys Val Arg 
    290                 295                 300                 


Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu Lys Phe Ile Asp Gln Lys 
305                 310                 315                 320 


Lys Leu Phe Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val 
                325                 330                 335     


Leu Asp Glu Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Lys Arg Thr 
            340                 345                 350         


Val Thr Glu Asn Thr Lys Ala Phe Gly Met Leu Gln Asp Leu Asn Asp 
        355                 360                 365             


Glu Glu Asn Val Leu Asn Lys Ile Asn Thr Gly Glu Ser Lys Ala Lys 
    370                 375                 380                 


Phe Asp Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn Lys 
385                 390                 395                 400 


Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Thr Lys Asn 
                405                 410                 415     


Thr Asp Asn Lys Ile Lys Ser Asn Leu Leu Gln Pro Leu Pro Glu Ala 
            420                 425                 430         


Phe Leu Ser Ile Asn Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
        435                 440                 445             


Glu Gln Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn 
    450                 455                 460                 


Asn Ser Lys Ile Leu Asn Lys Glu Phe Ile Lys Ala Ile Lys Leu Lys 
465                 470                 475                 480 


Leu Asn Asp Leu Asp Val Phe Tyr Lys Arg Ser Gln Gly Arg Lys Gln 
                485                 490                 495     


Lys His Ala Tyr Leu Thr Lys Asp Lys Lys Tyr Asp Asn Glu Lys Ile 
            500                 505                 510         


Asn Glu Leu Lys Asn Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu 
        515                 520                 525             


Tyr Asn Leu Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp 
    530                 535                 540                 


Leu Asn Ile Ala Asp Val Gln Ala Lys Asn Ala Ile Ser Asp Arg Ile 
545                 550                 555                 560 


Lys Leu Met Lys Arg Asp Cys Ile Asn Arg Leu Lys Ser Met Lys Lys 
                565                 570                 575     


Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp 
            580                 585                 590         


Ile Val Asp Met Ile Ile Asp Glu Glu Lys Lys Lys Lys Ile Thr Ser 
        595                 600                 605             


Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Lys 
    610                 615                 620                 


Glu Lys Lys Glu Leu Phe Ile Leu Ile Cys Asn Asn Glu Leu Lys Leu 
625                 630                 635                 640 


Asn Asp Asp Asp Gly His Pro Phe Phe Lys Asn Ile Asn Phe Ser Asn 
                645                 650                 655     


Tyr Lys Tyr Thr Ser Glu Ile Tyr Gln Lys Tyr Leu Glu Glu Lys Gly 
            660                 665                 670         


His Lys Met Val Lys Glu Tyr Asn Pro Arg Lys Glu Asn Tyr Val Glu 
        675                 680                 685             


Lys Asp Lys Ser Trp Leu Glu Ile Asn Phe Tyr Lys Lys Glu Trp Asn 
    690                 695                 700                 


Glu Asn Ala Lys Lys Asp Leu Thr Val Val Lys Leu Pro Asp Asp Lys 
705                 710                 715                 720 


Ser Lys Ile Pro Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser 
                725                 730                 735     


Phe Glu Asn Trp Phe Lys Tyr Val Thr Asn Gly Lys Glu Thr Thr Asp 
            740                 745                 750         


Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp Glu Thr Leu 
        755                 760                 765             


Lys Glu Leu Leu Lys Lys Glu Leu Ser Lys Asn Asn Ile Glu Phe Lys 
    770                 775                 780                 


Glu Glu Asp Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Asp Lys Cys 
785                 790                 795                 800 


Arg Asn Asp Lys Thr Gln Lys Phe Tyr Ser Ala Glu Arg Glu Tyr Thr 
                805                 810                 815     


Phe Glu Glu Glu Lys Leu Asn Phe His Ile Asn Thr Lys Ser Lys Phe 
            820                 825                 830         


Glu Glu Tyr Ile Asn Pro Glu Phe Ala Glu Lys Val Phe Arg Leu Lys 
        835                 840                 845             


Asn Gln Asn Arg Glu Lys Asp Asn Ile Ser Gly Arg Arg Leu Pro Pro 
    850                 855                 860                 


Leu Lys Met Lys Glu Val Thr Lys Asn Met Val Lys Arg Ile Gly Asn 
865                 870                 875                 880 


Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Leu Met Leu 
                885                 890                 895     


Leu Met Phe Glu Lys Leu Val Asp Asn Asn Leu Lys Leu Lys Leu Glu 
            900                 905                 910         


Asn Val Asp Lys Leu Leu Asn Glu Ser Ile Glu Ile Asn Gln Ser Ile 
        915                 920                 925             


Ser Gly Lys Leu Ser Phe Asp Asp Ser Gly Asp Asn Glu Asn Lys Lys 
    930                 935                 940                 


Asp Arg Ala Ile Ile Cys Arg Asn Ile Thr Glu Thr Arg Lys Arg Lys 
945                 950                 955                 960 


Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Arg Arg Leu Pro Glu 
                965                 970                 975     


Leu Phe Glu Tyr Phe Glu Glu Glu Asn Ile Pro Ile Glu Lys Ile Lys 
            980                 985                 990         


Ile Glu Leu Asp Thr Tyr Ser Lys  Ala Lys Asp Val Val  Phe Asp Leu 
        995                 1000                 1005             


Ile Phe  Asp Leu Glu Arg Ala  Ile Ile Asn Lys Asp  Glu Asn Arg 
    1010                 1015                 1020             


Ile Lys  Glu Leu Asn Lys Asp  Lys Asn Gly Val Ile  Gln Thr Gly 
    1025                 1030                 1035             


Asn Ile  Gln His Lys Pro Tyr  Leu Phe Trp Leu Leu  Glu Lys Asn 
    1040                 1045                 1050             


Leu Ile  Thr Glu Gln Glu Phe  Thr Phe Met Asn Met  Val Arg Asn 
    1055                 1060                 1065             


Thr Phe  Ser His Asn Gln Phe  Pro Gln Lys Lys Thr  Met Glu Leu 
    1070                 1075                 1080             


Phe Ile  Lys Asn Trp Asn Glu  Asn Glu Phe Ala Lys  Gln Ile Leu 
    1085                 1090                 1095             


Asn Val  Tyr Asn Gln Lys Asn  Asn Asn Leu Ile Lys  Ser Ile Lys 
    1100                 1105                 1110             


Asp Ile  
    1115 


<210>  2758
<211>  994
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2758

Met Asp Ser Lys Tyr Ile Leu Gly Ser Tyr Leu Asn Met Ala Asn Asp 
1               5                   10                  15      


Asn Phe Ile Asn Thr Ile His Leu Leu Ala Lys Lys Leu Lys Thr Pro 
            20                  25                  30          


Lys Gly Glu Asp Gln Asn Leu Asp Gln Val Val Ser Tyr Ile Thr Arg 
        35                  40                  45              


Ile Phe Asp Asn Ser Asn Gln Val Pro Glu Thr Glu Gln Ile Val Glu 
    50                  55                  60                  


Phe Tyr Phe Pro Trp Leu Glu Ala Leu Lys Asn Ala Asn Gly Phe Gly 
65                  70                  75                  80  


Lys Ser Glu Leu Pro Glu Leu Lys Ile Phe Tyr Lys Asp Val Leu Cys 
                85                  90                  95      


Ser Phe Ala Glu Asn Leu Lys Asp Leu Arg Asn Asn Tyr Thr His Tyr 
            100                 105                 110         


Ile His Lys Thr Ile Ser Tyr His Pro Ile Ile Tyr Lys Lys Glu Gly 
        115                 120                 125             


Asn Thr Leu Gln Ser Ser Leu Pro Lys Ala Leu Leu Gln Ile Tyr Asp 
    130                 135                 140                 


Ala Ser Ile Lys Leu Ala Lys Glu Arg Phe Ser Ala Asp Glu Asn Ala 
145                 150                 155                 160 


Val Thr His Leu Arg Arg Tyr Lys Met Val Gly Lys Lys Val Val Arg 
                165                 170                 175     


Lys Thr Glu Ala Asp His Phe Leu Tyr Leu Leu Glu Lys Asp His Leu 
            180                 185                 190         


Leu Thr Glu Lys Gly Ile Ala Phe Phe Thr Ser Leu Phe Leu Asn Arg 
        195                 200                 205             


Lys Tyr Gly Tyr Leu Met Leu Lys Gln Leu Lys Gly Phe Lys Gln Gly 
    210                 215                 220                 


Gly Thr Leu Ala Tyr Arg Leu Thr Leu Glu Thr Phe Leu Ala Tyr Ser 
225                 230                 235                 240 


Asn Ile Lys Pro Val Glu Arg Leu Lys Ala Asp Lys Tyr Ser Asp Val 
                245                 250                 255     


Ala Phe Ile Met Asp Leu Leu Gly Glu Ile Ser Lys Ile Pro Lys Glu 
            260                 265                 270         


Leu Tyr His Ile Leu Pro Glu Thr Tyr Ile Leu Gln Tyr Lys Asn Lys 
        275                 280                 285             


Leu His Ile Glu Leu Asn Glu Asp Ile Ser Leu Glu Ala Tyr Cys Ser 
    290                 295                 300                 


Arg Gly Arg Asn Arg Phe Asp Gln Leu Ala Leu Thr Tyr Leu Asp Arg 
305                 310                 315                 320 


Leu Glu Asp Phe Lys Gln Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr 
                325                 330                 335     


Ile His Asn Gly Tyr Met Lys Val Arg Ile Asp Gly Thr Glu Gln Glu 
            340                 345                 350         


Arg Tyr Leu Ser Glu Lys Met Tyr Gly Cys Cys Lys Asn Ile Tyr Arg 
        355                 360                 365             


Asp Leu Ser Ala Ile Val Ala Lys Gln Tyr Asn Ile Lys Val Lys Asp 
    370                 375                 380                 


Ser Thr Glu Thr Ser Tyr Met Leu Pro Asn Asp Phe Gln Pro His Val 
385                 390                 395                 400 


Ile Arg Ala Tyr Pro His Tyr Val Ile Asn Asn Asn Asn Ile Gly Ile 
                405                 410                 415     


Arg Leu Leu Asp Glu Gly Glu Ser Gly Phe Pro Ile Leu Glu Asn Arg 
            420                 425                 430         


Gly Thr Lys Asn Val Val Pro His Phe Trp Met Ser Lys Tyr Asp Leu 
        435                 440                 445             


Pro Ala Leu Leu Phe Tyr Ala Tyr Leu Arg Ser Asp Ser Arg Phe Ala 
    450                 455                 460                 


Ser Lys Cys Lys Lys Thr Ile Asp Glu Ile Leu Arg Gly Tyr Leu Ser 
465                 470                 475                 480 


Lys Ser Lys Asp Lys Lys Pro Lys Gln Ala Glu Lys Val Ser Val Leu 
                485                 490                 495     


Met Leu Arg Arg Ile Asp Lys Ala Ile Ile Trp Thr Gln Thr Lys Leu 
            500                 505                 510         


Asn Glu Ala Glu Lys Gln Arg Asp Asn Lys Lys Ser Phe Lys Ile Gly 
        515                 520                 525             


Glu Lys Ala Asp Ile Leu Ala His Asp Met Leu Trp Leu Gln Pro Ala 
    530                 535                 540                 


Lys Glu Ser Lys Asp Lys Val Ser Gly Ala Asn Phe Arg Ala Leu Gln 
545                 550                 555                 560 


Thr Ser Leu Ala Phe Phe Lys Arg Asn Glu Leu Glu Asp Ile Phe Lys 
                565                 570                 575     


Lys Ser Phe Leu Ile Gly Gly Asn Asn Pro His Pro Phe Leu Ser Arg 
            580                 585                 590         


Ile Lys Ile Asn Thr Met Pro Ser Leu Phe Asp Phe Tyr Leu Ala Tyr 
        595                 600                 605             


Met Arg Glu Arg Leu Asn Tyr Trp Glu Lys Ile Lys Leu Lys Leu Leu 
    610                 615                 620                 


Lys Gly His Ile Asn Val Ser Cys His Pro Leu Arg Lys Leu Asn His 
625                 630                 635                 640 


Gly Lys Pro Val Asp Gln Asp Asn Lys Lys Asp Glu Gln Pro Ile Phe 
                645                 650                 655     


Leu Pro Arg Gly Ile Phe Asn Asp Val Ile Lys Asn Cys Leu Gln Lys 
            660                 665                 670         


Thr Lys Leu Gly Ile Tyr Leu Lys Asp Gln Gly Val Glu Thr Arg Ser 
        675                 680                 685             


Trp Asn Val Ala Tyr Gln Ile Leu Lys Phe His Glu Ile Ile Asn Asp 
    690                 695                 700                 


Asp Asp Ile Gln Glu Phe Tyr Lys Gln Pro Arg Lys Tyr Ala Ile Leu 
705                 710                 715                 720 


Asp Glu Asn His Tyr Leu Thr Leu Glu Glu Arg Thr Asp Arg Leu Lys 
                725                 730                 735     


Asp Leu Lys Pro Glu Cys Ile Glu Val Ser Lys Ala Asn Asp Ile Leu 
            740                 745                 750         


Glu Lys Glu Asp Tyr Leu Leu Arg Lys Ser Tyr Asn Gln Val Cys Asp 
        755                 760                 765             


Asn Glu Ser Ala Ile Arg Leu Tyr Gln Val Gln Asp Ile Leu Leu Phe 
    770                 775                 780                 


Met Ile Ala Gln Arg Leu Cys Asn Glu Ile Ile Leu Gly Asp Lys Gln 
785                 790                 795                 800 


Glu Lys Lys Glu Lys Val Glu Thr Ser Phe Ser Leu Thr Leu Lys Asn 
                805                 810                 815     


Leu Ser Lys Lys Phe Asp Gln Pro Val His Phe Glu Ile Lys Met Asn 
            820                 825                 830         


Asn Val Asn Leu Phe Ser Asp Thr Asp Ile Pro Val Lys Asn Phe Gly 
        835                 840                 845             


Lys Met Leu Arg Leu Lys Lys Asp Ala Arg Phe Ile Ser Tyr Asp Lys 
    850                 855                 860                 


Leu Phe Lys Gly Gln Lys Gln Asn Ile Asn Tyr Asn Asp Tyr Cys Lys 
865                 870                 875                 880 


Glu Glu Glu Tyr Phe Asp Ile Cys Arg Ile Gln Met Val Lys Leu Cys 
                885                 890                 895     


His Glu Leu Glu Glu Lys Leu Leu Glu Glu Gly Ile Ile Thr Glu Ser 
            900                 905                 910         


Pro Asn Ser Gly Tyr Tyr Pro Phe Ala Asp Leu Val Gln Ile Ile Ile 
        915                 920                 925             


Asn Gln Gly Val Val Ile Ser Ser Ser Asp Val Lys Phe Ile Leu Glu 
    930                 935                 940                 


Ala Arg Asn Met Phe Leu His Asn Glu Tyr Lys Gln Cys Cys Val Asn 
945                 950                 955                 960 


Ser Ile Asn Ser Ile Asp Ser Phe Ile Ala Glu Lys Val His Asn Leu 
                965                 970                 975     


Phe Lys Gln Lys Met Asp Asn Ile Leu Gly Gln Leu Glu Ser Ile Lys 
            980                 985                 990         


Ser Ser 
        


<210>  2759
<211>  1089
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2759

Met Lys Glu Asn Thr His Thr Leu Ser Glu Val Ser Lys Val Tyr Thr 
1               5                   10                  15      


Leu Glu Thr Thr Pro Glu Tyr Phe Gly Ala Tyr Leu Asn Ile Ala Arg 
            20                  25                  30          


His Asn Val Phe Met Ile Ser Gln Glu Met Ser Arg Lys Phe Asn Lys 
        35                  40                  45              


Lys Asp Pro Ala Gln Glu Asp Gly Gln Ile Gly Asp Ser Phe Leu Thr 
    50                  55                  60                  


Lys Ser Leu Val Pro Thr Asp Ser Gly Asp Phe Ile Tyr Gln Asn Leu 
65                  70                  75                  80  


Cys Arg Tyr Leu Pro Leu Ala Asn Ala Phe Ser Ser Asp Phe Arg Arg 
                85                  90                  95      


Ser Ile Gly Met Asp Asp Asp Ala Thr Gly Met Asp Ile Ile Lys Leu 
            100                 105                 110         


Ser Gly Phe Leu Lys Ile Ala Phe Lys Glu Leu Ser Asp Phe Arg Asn 
        115                 120                 125             


Glu Tyr Thr His Tyr Phe Ser Lys Lys Thr Gly Thr His Arg Lys Val 
    130                 135                 140                 


His Ile Glu Asp Glu Leu Ala Ile Gln Leu Lys Val Leu Phe Glu Val 
145                 150                 155                 160 


Ala Val Lys Leu Ala Gln Lys Arg Phe Gln Asp Val Ile Pro Asp Lys 
                165                 170                 175     


Cys Phe Asp Thr Val Glu Lys Asn Ile Glu Ser Glu Leu Phe Val Lys 
            180                 185                 190         


Asp Thr Asn Gln Ile Thr Thr Lys Gly Leu Val Phe Phe Cys Cys Leu 
        195                 200                 205             


Phe Leu Asp Lys Glu Asn Ala Phe His Phe Ile Asn Lys Ile Tyr Gly 
    210                 215                 220                 


Phe Lys Lys Thr Gly Thr Pro Asp Phe Gln Ala Thr Arg Glu Val Phe 
225                 230                 235                 240 


Ser Val Leu Cys Val Lys Leu Pro His Asn Lys Leu Ser Ser Arg Asp 
                245                 250                 255     


Tyr Gln Gln Ala Leu Leu Met Asp Ala Leu Asn Tyr Leu Gln Arg Ala 
            260                 265                 270         


Pro Asn Glu Leu Tyr Asn Ala Leu Asn Glu Asn Asp Gln Lys Gln Phe 
        275                 280                 285             


Lys Pro Thr Leu Asn Ala Asn Tyr Asp Asp Lys Asp Tyr Glu Ser Tyr 
    290                 295                 300                 


Leu Lys Asp Ile Ser Thr Leu Lys Arg Ser Arg Asp Arg Phe Pro Glu 
305                 310                 315                 320 


Phe Ala Leu Lys Phe Leu Asp Ala Ser Lys Asn Phe Lys Tyr Asp Phe 
                325                 330                 335     


Gln Ile Tyr Leu Gly Lys Val Glu Thr Lys Ser Tyr Ser Lys Arg Val 
            340                 345                 350         


Leu Gly Gln Met Pro Glu Glu Lys Asn Arg Ser Ile Val Lys Asp Val 
        355                 360                 365             


Lys Thr Phe Gly Thr Leu Ser Thr Tyr Asn Asp Asp Val Gln Lys Lys 
    370                 375                 380                 


Ile Ile Glu Glu Lys Glu Phe Ile Glu Leu Phe Lys Gly Thr Glu Val 
385                 390                 395                 400 


Lys Phe Ile Gln Tyr Ala Pro Arg Tyr His Ile Ser Gly Asn Lys Ile 
                405                 410                 415     


Ala Leu Ala Phe Ser Asp Gln Lys Pro Ser Phe Asn Lys Glu Ser Pro 
            420                 425                 430         


Gln Ala Phe Leu Ser Ile Ser Ala Leu Pro Lys Val Val Leu Leu Glu 
        435                 440                 445             


Leu Leu Ser Gln Gly Ala Ala Ser Thr Leu Ile Lys Ile Phe Leu Asp 
    450                 455                 460                 


Lys Asn Glu His Cys Leu Leu Asn Arg Gln Trp Ile Asp Lys Ile Lys 
465                 470                 475                 480 


Lys Gln Leu Thr Ser Tyr Ser Ile Leu Lys Arg Val Ser Ala Asp Ser 
                485                 490                 495     


Lys Glu Pro Leu Asn Cys Arg Thr Lys Glu Lys Tyr Asp Glu Tyr Arg 
            500                 505                 510         


Ala Glu Phe Asn His Arg Lys Phe Ser Leu Asp Glu Ile Leu Lys Ala 
        515                 520                 525             


Lys Gly Leu Asp Cys Lys Gln Ile Pro Ser Arg Ile Ile Asp Tyr Trp 
    530                 535                 540                 


Leu Asn Ile Glu Asp Thr Gly Asn Asn Tyr Thr Phe Lys Glu Arg Ile 
545                 550                 555                 560 


Lys Glu Ala Ala Asn Asp Cys Lys Lys Gln Ile Lys Asp Ile Glu Lys 
                565                 570                 575     


Gly Arg Gln Leu Lys Val Gly Glu Met Ala Ser Glu Leu Ala Arg Asp 
            580                 585                 590         


Ile Ile Lys Leu Val Ile Asp Arg Asp Val Lys Thr Lys Ile Thr Ser 
        595                 600                 605             


Phe Tyr Tyr Asn Leu Leu Gln Glu Cys Leu Ala Leu Tyr Ala Asn Asn 
    610                 615                 620                 


Glu Lys Lys Gln Leu Phe Trp Glu Leu Cys Lys Arg Asp Leu Asn Leu 
625                 630                 635                 640 


Leu Asp Lys Gly Lys Gly His Pro Phe Leu Ala Asp Leu Glu Cys Lys 
                645                 650                 655     


Lys Thr Asn Ser Thr Leu Glu Phe Tyr Lys Ala Tyr Leu Leu Leu Lys 
            660                 665                 670         


Lys Tyr Trp Leu His Asn Thr Phe Tyr Ser Ile Lys Trp Asn Glu Lys 
        675                 680                 685             


Lys Arg Lys Asn Glu Thr Val Ile Pro Ile Pro Lys Asn Lys Leu Glu 
    690                 695                 700                 


Leu Pro Leu Thr Tyr Gln Lys Trp Ile Glu Ser Asp His Asp Phe Asp 
705                 710                 715                 720 


Ser Trp Leu Glu Ser Val Gln Thr Gln Asn Ser Thr Ser Thr Gln Gln 
                725                 730                 735     


Thr Pro Lys Pro Ala Asp Leu Pro Thr Asn Leu Phe Asp Ser Ala Leu 
            740                 745                 750         


Ile Ala Lys Leu Lys Glu Glu Glu Val Thr Ile Ser Asp Asp Lys Glu 
        755                 760                 765             


Thr Tyr Asn Tyr Ser Arg Leu Leu Gly Met Trp Leu Lys Asp Leu Gln 
    770                 775                 780                 


Pro Phe Tyr Gln Gln Lys Arg His Tyr Thr Ile Phe Lys Asn Arg Pro 
785                 790                 795                 800 


Tyr Glu Cys Val Val Lys Val Asp Pro Thr Glu Asn Lys Pro Ile Lys 
                805                 810                 815     


Asp Tyr Tyr Thr Ser Lys Leu Asp Asp Val Ile Lys Gln Cys Lys Lys 
            820                 825                 830         


Glu Lys Glu Lys Leu Ser Glu Glu Gln Leu Lys Val Ile Phe Lys Lys 
        835                 840                 845             


Ala Val Ala Glu Lys Glu Lys Lys Ile Arg Tyr Tyr Cys Thr Glu Asp 
    850                 855                 860                 


Arg Ile Leu Met Lys Ile Ile Asn Tyr Val Phe Arg Glu Met Asn Thr 
865                 870                 875                 880 


Lys Asn Ser Asp Ser Gly Ile Ser Lys Phe Thr Ile Ser Leu Asn Asp 
                885                 890                 895     


Ile Tyr Pro Asn Ser Ala Lys Asn Pro Leu Glu Glu Glu Glu Asp Met 
            900                 905                 910         


Glu Ala Arg Leu Tyr Asp Arg Thr Ile Val Ala His Arg Lys Arg Lys 
        915                 920                 925             


Asp Tyr Ser Phe Phe Ile Arg Phe Leu His Asp Glu Arg Met Gln Asn 
    930                 935                 940                 


Leu Leu Pro Tyr Phe Asn Glu Glu Lys Ile Asp Phe Asp Lys Leu Val 
945                 950                 955                 960 


Ala Glu Met Lys Asp Tyr Glu Lys Tyr Arg Glu Val Val Phe Ser Lys 
                965                 970                 975     


Ser Phe Glu Leu Glu Glu Ser Ile Leu Ser Val Ile Ser Pro Glu Gly 
            980                 985                 990         


Lys Ile Lys Leu Phe Asn Asp Asn  Thr Thr Asp Cys Gly  Asn Val Gln 
        995                 1000                 1005             


Phe Ile  Cys Tyr Leu Asn Arg  Leu Lys Asp Asn Gly  Leu Ile Asp 
    1010                 1015                 1020             


Gln Asn  Asp Tyr Asp Leu Leu  Phe Glu Ile Arg Asn  Lys Phe Cys 
    1025                 1030                 1035             


His Asn  Glu Phe Pro Arg Lys  Ala Lys Ile Lys Phe  Ile Pro Ser 
    1040                 1045                 1050             


Phe Asp  Val Ser Gln Tyr Lys  Phe Ser Gln Gln Ile  Val Ser Trp 
    1055                 1060                 1065             


Tyr Glu  Lys Lys Ile Asn Met  Ile Leu Glu Asn Leu  Arg Lys Leu 
    1070                 1075                 1080             


Asp Lys  Asn Cys Leu Leu 
    1085                 


<210>  2760
<211>  934
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2760

Met Gly Ala Ile Lys Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe Glu Ile Ala 
            900                 905                 910         


Met Val Ser Met Phe Pro Asp Leu Lys Lys Ala Thr Pro Gly Asn Tyr 
        915                 920                 925             


Tyr Asp Phe Asn Glu Leu 
    930                 


<210>  2761
<211>  1115
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2761

Met Glu Thr Leu Glu Leu Gln Lys Lys Thr Glu Tyr Asn Ala Ala His 
1               5                   10                  15      


Ile Tyr Lys Thr Ile Lys Glu Asp Pro Gln Tyr Phe Gly Gly Tyr Leu 
            20                  25                  30          


Asn Met Ala Arg His Asn Ile Tyr Ser Ile Ser Asn His Ala Ser Ser 
        35                  40                  45              


Lys Phe Asn Leu Lys Pro Leu Ser Asp Glu Glu Lys Ile Ile Asp Ser 
    50                  55                  60                  


Phe Leu Cys Asn Glu Lys Lys Lys His Leu Asn Trp Asn His Val Phe 
65                  70                  75                  80  


Ser Ile Ala Leu Lys Phe Leu Pro Ile Ile Lys Val Phe Asp Phe Glu 
                85                  90                  95      


Ser Leu Pro Lys Asn Glu Gln Ala Asn Asn Asn Asn Thr Gly Lys Asp 
            100                 105                 110         


Phe Ala Gln Met Ala Gln Thr Leu Lys Lys Leu Phe Ser Glu Ile Gln 
        115                 120                 125             


Gln Leu Arg Asn Asp Tyr Ser His Tyr Tyr Ser Ile Asn Asn Asn Asp 
    130                 135                 140                 


Ile Arg Lys Ile Ser Val Ser Asn Glu Val Ala Ile Phe Leu Gln Asp 
145                 150                 155                 160 


Asn Ile Lys Arg Ala Ile Glu Tyr Thr Lys Ser Arg Phe Ser Gly Val 
                165                 170                 175     


Leu Ser Asp Glu Asp Phe Glu Asn Ala Ser Asn Arg Lys Leu Ile Glu 
            180                 185                 190         


Gln Asn Asn Ile Leu Thr Thr Asp Gly Phe Val Phe Leu Ile Ser Met 
        195                 200                 205             


Phe Leu Glu Arg Glu His Ala Phe Gln Phe Ile Gly Lys Ile Lys Gly 
    210                 215                 220                 


Leu Lys Gly Thr Gln Ser Lys Ser Phe Ile Ala Thr Arg Glu Val Phe 
225                 230                 235                 240 


Met Ala Phe Cys Leu Lys Leu Pro His Asp Arg Phe Val Ser Glu Asp 
                245                 250                 255     


Lys Thr Gln Ala Leu Thr Leu Asp Ile Ile Asn Thr Leu Asn Arg Cys 
            260                 265                 270         


Pro Lys Glu Leu Tyr Ser Ile Ile Thr Glu Lys Glu Lys Gln Gln Phe 
        275                 280                 285             


Lys Pro Thr Leu Asp Asn Leu Lys Leu Asn Asn Leu Leu Glu Asn Ser 
    290                 295                 300                 


Leu Asn Asp Thr Glu Val Ile Glu Asp Tyr Asp Thr Tyr Ile Glu Ser 
305                 310                 315                 320 


Leu Thr Arg Lys Ile Arg His Ser Asn Arg Phe Ser Tyr Phe Ala Leu 
                325                 330                 335     


Lys Tyr Ile Asp Glu Thr Asn Ile Phe Gln Asn Ile Arg Phe Gln Ile 
            340                 345                 350         


Asn Leu Gly Lys Leu Leu Ile Asp Lys Tyr Glu Lys Pro Ile Asn Asn 
        355                 360                 365             


Glu Met Tyr Pro Arg Thr Ile Ile Glu Asn Val Lys Ala Phe Gly Lys 
    370                 375                 380                 


Leu Ser Asp Phe Glu Asp Glu Thr Glu Ala Leu His Gln Ile Asp Lys 
385                 390                 395                 400 


Asn Gly Asn Ser Leu Gly Phe Glu Gln Phe Ala Pro His Tyr Asn Thr 
                405                 410                 415     


Ser Asn Asn Lys Ile Ala Leu Tyr Thr Asn Asn Ala Lys Ala Ile Ile 
            420                 425                 430         


Ile Asn Asn Pro Lys Ala Lys Ser Lys Ile Lys Asn Asn Leu Lys Gln 
        435                 440                 445             


Pro Leu Pro Glu Ala Phe Leu Ser Leu His Glu Leu Pro Lys Ile Ile 
    450                 455                 460                 


Leu Leu Glu Tyr Leu Gln Lys Gly Lys Ser Glu Glu Ile Ile Asn Asp 
465                 470                 475                 480 


Phe Ile Leu Ala Asn Asn Thr Lys Ile Thr Asn Arg Lys Phe Ile Glu 
                485                 490                 495     


Glu Val Lys Arg Met Leu Pro Asn Asp Trp Asp Ile Phe Lys Lys Lys 
            500                 505                 510         


Thr Asp Pro Lys Asn Ser Gln Ala Tyr Lys Pro Ser Glu Leu Thr Lys 
        515                 520                 525             


Leu Lys Thr Arg Lys Lys Ile Leu Asn Thr Val Leu Glu Pro His Asn 
    530                 535                 540                 


Leu Asn Asp Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp Leu Asn 
545                 550                 555                 560 


Ile Val Asp Val Asn Ile Asp Arg Ala Ile Ala Asp Lys Ile Lys Leu 
                565                 570                 575     


Met Lys Arg Asp Gly Thr Asp Arg Leu Lys Ala Phe Asn Lys Phe Lys 
            580                 585                 590         


Lys Glu Gly Lys Gly Lys Ile Pro Lys Ile Gly Glu Met Ala Thr Phe 
        595                 600                 605             


Leu Ala Lys Asp Ile Val Asn Met Ile Ile Ser Glu Asp Lys Lys Lys 
    610                 615                 620                 


Lys Ile Thr Ser Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu 
625                 630                 635                 640 


Phe Ala Asp Pro Glu Lys Lys Ala Leu Phe Ile Glu Ile Ile Thr Lys 
                645                 650                 655     


Asp Leu Gln Leu Asn Lys Phe Asp Gly His Pro Phe Leu Lys Glu Ile 
            660                 665                 670         


Gln Leu Arg Asp Ile His Tyr Thr Gln Asp Phe Tyr Ser Ile Tyr Leu 
        675                 680                 685             


Gln His Lys Val Cys Lys Leu Val Ser Val Lys Asn Tyr Lys Lys Gly 
    690                 695                 700                 


Arg Thr Asp Ser Ile Asp Lys Ser Trp Met Thr Lys Asn Phe Tyr Cys 
705                 710                 715                 720 


Lys Glu Trp Asp Asn Lys Leu Ser Lys Gln Lys Thr Val Val Lys Leu 
                725                 730                 735     


Pro Ala Asp Leu Ser Asn Ile Pro Phe Ser Leu Arg Gln Leu Ile Glu 
            740                 745                 750         


Lys Glu Ser Ser Ser Leu Tyr Glu Trp Leu Asp Asn Ile Ile Asn Gly 
        755                 760                 765             


Lys Asn Ser Asn Asp Gly Lys Arg Pro Ile Ser Leu Pro Thr Asn Leu 
    770                 775                 780                 


Phe Asp Glu Glu Leu Ile Asn Leu Leu Gln Met Lys Leu Asn Glu Lys 
785                 790                 795                 800 


Asn Ala Ser Tyr Pro Ser Asp Ala Lys Tyr Asn Glu Leu Phe Lys Ile 
                805                 810                 815     


Trp Trp Thr Thr Arg Asn Asp Asp Thr Gln Ser Phe Tyr Asn Ala Glu 
            820                 825                 830         


Arg Glu Tyr Val Ile Tyr Asp Gln Lys Ile Asn Phe Lys Leu Gln Lys 
        835                 840                 845             


Gly Ala Lys Phe Ala Tyr Phe Tyr Ala Asp Ser Leu Lys Gln Ala Phe 
    850                 855                 860                 


Lys Asn Gln Gln Asp Lys Arg Ala Ile Lys Lys Arg Ile Asp Arg Lys 
865                 870                 875                 880 


Leu Pro Asp Ile Glu Leu Thr Gln Val Glu Lys Val Phe Lys Arg Thr 
                885                 890                 895     


Ile Ser Asn Thr Glu Lys His Ile Arg Leu Thr Gln Glu Gln Asp Gln 
            900                 905                 910         


Ile Met Ala Leu Met Leu Glu Lys Leu Met Ser Val Asp Lys Asn Leu 
        915                 920                 925             


Asn Ile Lys Leu Ser Glu Ile Ser Thr Leu Leu Asn Asp Thr Ile Thr 
    930                 935                 940                 


Val Arg Lys Thr Val Ser Gly Lys Leu Ser Phe Ser Asn Glu Asn Thr 
945                 950                 955                 960 


Ile Ser Lys Ile Ile Leu Asp Gln Arg Lys Arg Lys Asp His Ser Met 
                965                 970                 975     


Leu Asn Lys Tyr Ile His Asp Arg Arg Leu Pro Glu Leu Phe Glu Tyr 
            980                 985                 990         


Phe Ala Asp Thr Glu Ile Pro Ile  Asn Asn Leu Lys Val  Glu Leu Glu 
        995                 1000                 1005             


Ser Tyr  Asn Thr Ala Lys His  Ile Val Leu Asp Ser  Ala Phe Lys 
    1010                 1015                 1020             


Leu Glu  Ala Thr Leu Ile Lys  Lys Asn Tyr Thr Asp  Gln Leu Leu 
    1025                 1030                 1035             


Ser Leu  Ile Asp Lys Lys Phe  Asn Gly Gln Ser Ile  Gln His Lys 
    1040                 1045                 1050             


Pro Tyr  Leu Met Phe Leu Arg  Ser Lys Gly Val Ile  Asn Glu Asn 
    1055                 1060                 1065             


Glu Phe  Leu Phe Leu Asn Met  Val Arg Asn Cys Phe  Ser His Asn 
    1070                 1075                 1080             


Gln Phe  Pro Gln Lys Ser Thr  Met Asn Leu Leu Ile  Asn Asp Trp 
    1085                 1090                 1095             


Asp Lys  Asn Asn Phe Ala Leu  Gln Ile Ala Thr Ile  Tyr Asn Asn 
    1100                 1105                 1110             


Lys Thr  
    1115 


<210>  2762
<211>  1131
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2762

Met Glu Lys Thr Ile Glu Asn Gln Thr Gln Ser Lys Arg Thr Leu Asn 
1               5                   10                  15      


Asn Thr Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Asp Glu Glu Lys Ile Thr Thr Ser Phe Leu Val Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Arg Gln Ser Leu Val Tyr Ser Asn Leu Thr 
65                  70                  75                  80  


Arg Tyr Met His Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Asp 
                85                  90                  95      


Asp Glu Arg Asp Lys Ala Glu Asn Tyr Gly Lys Asp Phe Gly Asn Leu 
            100                 105                 110         


Thr Asp Thr Leu Lys Glu Ile Phe Lys Glu Leu Asn Glu Phe Arg Asn 
        115                 120                 125             


Asp Tyr Ser His Tyr Tyr Ser Thr Glu Lys Lys Asp Lys Arg Lys Thr 
    130                 135                 140                 


Ile Val Ser Asp Lys Leu Lys Asn Phe Leu Asn Ile Asn Tyr Thr Arg 
145                 150                 155                 160 


Ala Ile Lys Tyr Thr Lys Ser Arg Phe Ile Asn Val Phe Ser Asp Asn 
                165                 170                 175     


Asn Phe Cys Leu Ala Glu Glu Ala Lys His Val Glu Asn Asp Asn Thr 
            180                 185                 190         


Ile Thr Gln Asp Gly Ile Val Phe Phe Thr Ser Met Phe Leu Asp Arg 
        195                 200                 205             


Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile Ile Gly Leu Lys Gly Thr 
    210                 215                 220                 


Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Thr Leu Met Ala Phe Cys 
225                 230                 235                 240 


Val Asn Leu Pro His Asp Lys Phe Val Ser Glu Asn Ser Glu Gln Gln 
                245                 250                 255     


Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu 
            260                 265                 270         


Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln His Phe Leu Pro Lys Leu 
        275                 280                 285             


Asp Asp Glu Gln Ile Asp Asn Val Leu Glu Asn Ser Val Pro Tyr Thr 
    290                 295                 300                 


Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn Ile Thr Lys Lys Val Arg 
305                 310                 315                 320 


Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu Lys Phe Ile Asp Gln Lys 
                325                 330                 335     


Lys Leu Phe Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val 
            340                 345                 350         


Leu Asp Glu Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Lys Arg Thr 
        355                 360                 365             


Val Thr Glu Asn Thr Lys Ala Phe Gly Met Leu Gln Asp Leu Asn Asp 
    370                 375                 380                 


Glu Glu Asn Val Leu Asn Lys Ile Asn Thr Gly Glu Ser Lys Ala Lys 
385                 390                 395                 400 


Phe Asp Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Thr Lys Asn 
            420                 425                 430         


Thr Asp Asn Lys Ile Lys Ser Asn Leu Leu Gln Pro Leu Pro Glu Ala 
        435                 440                 445             


Phe Leu Ser Ile Asn Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
    450                 455                 460                 


Glu Gln Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn 
465                 470                 475                 480 


Asn Ser Lys Ile Leu Asn Lys Glu Phe Ile Lys Ala Ile Lys Leu Lys 
                485                 490                 495     


Leu Asn Asp Leu Asp Val Phe Tyr Lys Arg Ser Gln Gly Arg Lys Gln 
            500                 505                 510         


Lys His Ala Tyr Leu Thr Lys Asp Lys Lys Tyr Asp Asn Glu Lys Ile 
        515                 520                 525             


Asn Glu Leu Lys Asn Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu 
    530                 535                 540                 


Tyr Asn Leu Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp 
545                 550                 555                 560 


Leu Asn Ile Ala Asp Val Gln Ala Lys Asn Ala Ile Ser Asp Arg Ile 
                565                 570                 575     


Lys Leu Met Lys Arg Asp Cys Ile Asn Arg Leu Lys Ser Met Lys Lys 
            580                 585                 590         


Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp 
        595                 600                 605             


Ile Val Asp Met Ile Ile Asp Glu Glu Lys Lys Lys Lys Ile Thr Ser 
    610                 615                 620                 


Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Lys 
625                 630                 635                 640 


Glu Lys Lys Glu Leu Phe Ile Leu Ile Cys Asn Asn Glu Leu Lys Leu 
                645                 650                 655     


Asn Asp Asp Asp Gly His Pro Phe Phe Lys Asn Ile Asn Phe Ser Asn 
            660                 665                 670         


Tyr Lys Tyr Thr Ser Glu Ile Tyr Gln Lys Tyr Leu Glu Glu Lys Gly 
        675                 680                 685             


His Lys Met Val Lys Glu Tyr Asn Pro Arg Lys Glu Asn Tyr Val Glu 
    690                 695                 700                 


Lys Asp Lys Ser Trp Leu Glu Ile Asn Phe Tyr Lys Lys Glu Trp Asn 
705                 710                 715                 720 


Glu Asn Ala Lys Lys Asp Leu Thr Val Val Lys Leu Pro Asp Asp Lys 
                725                 730                 735     


Ser Lys Ile Pro Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser 
            740                 745                 750         


Phe Glu Asn Trp Phe Lys Tyr Val Thr Asn Gly Lys Glu Thr Thr Asp 
        755                 760                 765             


Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp Glu Thr Leu 
    770                 775                 780                 


Lys Glu Leu Leu Lys Lys Glu Leu Ser Lys Asn Asn Ile Glu Phe Lys 
785                 790                 795                 800 


Glu Glu Asp Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Asp Lys Cys 
                805                 810                 815     


Arg Asn Asp Lys Thr Gln Lys Phe Tyr Ser Ala Glu Arg Glu Tyr Thr 
            820                 825                 830         


Phe Glu Glu Glu Lys Leu Asn Phe His Ile Asn Thr Lys Ser Lys Phe 
        835                 840                 845             


Glu Glu Tyr Ile Asn Pro Glu Phe Ala Glu Lys Val Phe Arg Leu Lys 
    850                 855                 860                 


Asn Gln Asn Arg Glu Lys Asp Asn Ile Ser Gly Arg Arg Leu Pro Pro 
865                 870                 875                 880 


Leu Lys Met Lys Glu Val Thr Lys Asn Met Val Lys Arg Ile Gly Asn 
                885                 890                 895     


Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Leu Met Leu 
            900                 905                 910         


Leu Met Phe Glu Lys Leu Val Asp Asn Asn Leu Lys Leu Lys Leu Glu 
        915                 920                 925             


Asn Val Asp Lys Leu Leu Asn Glu Ser Ile Glu Ile Asn Gln Ser Ile 
    930                 935                 940                 


Ser Gly Lys Leu Ser Phe Asp Asp Ser Gly Asp Asn Glu Asn Lys Lys 
945                 950                 955                 960 


Asp Arg Ala Ile Ile Cys Arg Asn Ile Thr Glu Thr Arg Lys Arg Lys 
                965                 970                 975     


Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Glu Glu Glu  Asn Ile Pro Ile Glu  Lys Ile Lys 
        995                 1000                 1005             


Ile Glu  Leu Asp Thr Tyr Ser  Lys Ala Lys Asp Val  Val Phe Asp 
    1010                 1015                 1020             


Leu Ile  Phe Asp Leu Glu Arg  Ala Ile Ile Asn Lys  Asp Glu Asn 
    1025                 1030                 1035             


Arg Ile  Lys Glu Leu Asn Lys  Asp Lys Asn Gly Val  Ile Gln Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Phe Trp Leu  Leu Glu Lys 
    1055                 1060                 1065             


Asn Leu  Ile Thr Glu Gln Glu  Phe Thr Phe Met Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Thr  Phe Ser His Asn Gln  Phe Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Leu Phe  Ile Lys Asn Trp Asn  Glu Asn Glu Phe Ala  Lys Gln Ile 
    1100                 1105                 1110             


Leu Asn  Val Tyr Asn Gln Lys  Asn Asn Asn Leu Ile  Lys Ser Ile 
    1115                 1120                 1125             


Lys Asp  Ile 
    1130     


<210>  2763
<211>  1131
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2763

Met Glu Lys Thr Ile Glu Asn Gln Thr Gln Ser Lys Arg Thr Leu Asn 
1               5                   10                  15      


Asn Thr Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg Leu Asn 
            20                  25                  30          


Ile Phe Asn Ile Ser Asn His Leu Ala Glu Lys Phe Gly Leu Ala Val 
        35                  40                  45              


Leu Asp Asp Glu Glu Lys Ile Thr Thr Ser Phe Leu Val Asp Lys Gly 
    50                  55                  60                  


Asn Lys Glu Tyr Lys Thr Arg Gln Ser Leu Val Tyr Ser Asn Leu Thr 
65                  70                  75                  80  


Arg Tyr Met His Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Asp 
                85                  90                  95      


Asp Glu Arg Asp Lys Ala Glu Asn Tyr Gly Lys Asp Phe Gly Asn Leu 
            100                 105                 110         


Thr Asp Thr Leu Lys Glu Ile Phe Lys Glu Leu Asn Glu Phe Arg Asn 
        115                 120                 125             


Asp Tyr Ser His Tyr Tyr Ser Thr Glu Lys Lys Asp Lys Arg Lys Thr 
    130                 135                 140                 


Ile Val Ser Asp Lys Leu Lys Asn Phe Leu Asn Ile Asn Tyr Thr Arg 
145                 150                 155                 160 


Ala Ile Lys Tyr Thr Lys Ser Arg Phe Ile Asn Val Phe Ser Asp Asn 
                165                 170                 175     


Asn Phe Cys Leu Ala Glu Glu Ala Lys His Val Glu Asn Asp Asn Thr 
            180                 185                 190         


Ile Thr Gln Asp Gly Ile Val Phe Phe Thr Ser Met Phe Leu Asp Arg 
        195                 200                 205             


Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile Ile Gly Leu Lys Gly Thr 
    210                 215                 220                 


Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Thr Leu Met Ala Phe Cys 
225                 230                 235                 240 


Val Asn Leu Pro His Asp Lys Phe Val Ser Glu Asn Ser Glu Gln Gln 
                245                 250                 255     


Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu 
            260                 265                 270         


Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln His Phe Leu Pro Lys Leu 
        275                 280                 285             


Asp Asp Glu Gln Ile Asp Asn Val Leu Glu Asn Ser Val Pro Tyr Thr 
    290                 295                 300                 


Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn Ile Thr Lys Lys Val Arg 
305                 310                 315                 320 


Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu Lys Phe Ile Asp Gln Lys 
                325                 330                 335     


Lys Leu Phe Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val 
            340                 345                 350         


Leu Asp Glu Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Lys Arg Thr 
        355                 360                 365             


Val Thr Glu Asn Thr Lys Ala Phe Gly Met Leu Gln Asp Leu Asn Asp 
    370                 375                 380                 


Glu Glu Asn Val Leu Asn Lys Ile Asn Thr Gly Glu Ser Lys Ala Lys 
385                 390                 395                 400 


Phe Asp Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn Lys 
                405                 410                 415     


Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Thr Lys Asn 
            420                 425                 430         


Thr Asp Asn Lys Ile Lys Ser Asn Leu Leu Gln Pro Leu Pro Glu Ala 
        435                 440                 445             


Phe Leu Ser Ile Asn Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
    450                 455                 460                 


Glu Gln Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn 
465                 470                 475                 480 


Asn Ser Lys Ile Leu Asn Lys Glu Phe Ile Lys Ala Ile Lys Leu Lys 
                485                 490                 495     


Leu Asn Asp Leu Asp Val Phe Tyr Lys Arg Ser Gln Gly Arg Lys Gln 
            500                 505                 510         


Lys His Ala Tyr Leu Thr Lys Asp Lys Lys Tyr Asp Asn Glu Lys Ile 
        515                 520                 525             


Asn Glu Leu Lys Asn Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu 
    530                 535                 540                 


Tyr Asn Leu Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp 
545                 550                 555                 560 


Leu Asn Ile Ala Asp Val Gln Ala Lys Asn Ala Ile Ser Asp Arg Ile 
                565                 570                 575     


Lys Leu Met Lys Arg Asp Cys Ile Asn Arg Leu Lys Ser Met Lys Lys 
            580                 585                 590         


Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp 
        595                 600                 605             


Ile Val Asp Met Ile Ile Asp Glu Glu Lys Lys Lys Lys Ile Thr Ser 
    610                 615                 620                 


Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Lys 
625                 630                 635                 640 


Glu Lys Lys Glu Leu Phe Ile Leu Ile Cys Asn Asn Glu Leu Lys Leu 
                645                 650                 655     


Asn Asp Asp Asp Gly His Pro Phe Phe Lys Asn Ile Asn Phe Ser Asn 
            660                 665                 670         


Tyr Lys Tyr Thr Ser Glu Ile Tyr Gln Lys Tyr Leu Glu Glu Lys Gly 
        675                 680                 685             


His Lys Met Val Lys Glu Tyr Asn Pro Arg Lys Glu Asn Tyr Val Glu 
    690                 695                 700                 


Lys Asp Lys Ser Trp Leu Glu Ile Asn Phe Tyr Lys Lys Glu Trp Asn 
705                 710                 715                 720 


Glu Asn Ala Lys Lys Asp Leu Thr Val Val Lys Leu Pro Asp Asp Lys 
                725                 730                 735     


Ser Lys Ile Pro Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser 
            740                 745                 750         


Phe Glu Asn Trp Phe Lys Tyr Val Thr Asn Gly Lys Glu Thr Thr Asp 
        755                 760                 765             


Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp Glu Thr Leu 
    770                 775                 780                 


Lys Glu Leu Leu Lys Lys Glu Leu Ser Lys Asn Asn Ile Glu Phe Lys 
785                 790                 795                 800 


Glu Glu Asp Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Asp Lys Cys 
                805                 810                 815     


Arg Asn Asp Lys Thr Gln Lys Phe Tyr Ser Ala Glu Arg Glu Tyr Thr 
            820                 825                 830         


Phe Glu Glu Glu Lys Leu Asn Phe His Ile Asn Thr Lys Ser Lys Phe 
        835                 840                 845             


Glu Glu Tyr Ile Asn Pro Glu Phe Ala Glu Lys Val Phe Arg Leu Lys 
    850                 855                 860                 


Asn Gln Asn Arg Glu Lys Asp Asn Ile Ser Gly Arg Arg Leu Pro Pro 
865                 870                 875                 880 


Leu Lys Met Lys Glu Val Thr Lys Asn Met Val Lys Arg Ile Gly Asn 
                885                 890                 895     


Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Leu Met Leu 
            900                 905                 910         


Leu Met Phe Glu Lys Leu Val Asp Asn Asn Leu Lys Leu Lys Leu Glu 
        915                 920                 925             


Asn Val Asp Lys Leu Leu Asn Glu Ser Ile Glu Ile Asn Gln Ser Ile 
    930                 935                 940                 


Ser Gly Lys Leu Ser Phe Asp Asp Ser Gly Asp Asn Glu Asn Lys Lys 
945                 950                 955                 960 


Asp Arg Ala Ile Ile Cys Arg Asn Ile Thr Glu Thr Arg Lys Arg Lys 
                965                 970                 975     


Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Arg Arg Leu Pro Glu 
            980                 985                 990         


Leu Phe Glu Tyr Phe Glu Glu Glu  Asn Ile Pro Ile Glu  Lys Ile Lys 
        995                 1000                 1005             


Ile Glu  Leu Asp Thr Tyr Ser  Lys Ala Lys Asp Val  Val Phe Asp 
    1010                 1015                 1020             


Leu Ile  Phe Asp Leu Glu Arg  Ala Ile Ile Asn Lys  Asp Glu Asn 
    1025                 1030                 1035             


Arg Ile  Lys Glu Leu Asn Lys  Asp Lys Asn Gly Val  Ile Gln Thr 
    1040                 1045                 1050             


Gly Asn  Ile Gln His Lys Pro  Tyr Leu Phe Trp Leu  Leu Glu Lys 
    1055                 1060                 1065             


Asn Leu  Ile Thr Glu Gln Glu  Phe Thr Phe Met Asn  Met Val Arg 
    1070                 1075                 1080             


Asn Thr  Phe Ser His Asn Gln  Phe Pro Gln Lys Lys  Thr Met Glu 
    1085                 1090                 1095             


Leu Phe  Ile Lys Asn Trp Asn  Glu Asn Glu Phe Ala  Lys Gln Ile 
    1100                 1105                 1110             


Leu Asn  Val Tyr Asn Gln Lys  Asn Asn Asn Leu Ile  Lys Ser Ile 
    1115                 1120                 1125             


Lys Asp  Ile 
    1130     


<210>  2764
<211>  1115
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2764

Met Thr Pro Gln Tyr Phe Gly Ala Tyr Leu Asn Met Ala Arg Leu Asn 
1               5                   10                  15      


Ile Phe Asn Ile Ser Asn His Leu Ala Glu Lys Phe Gly Leu Ala Val 
            20                  25                  30          


Leu Asp Asp Glu Glu Lys Ile Thr Thr Ser Phe Leu Val Asp Lys Gly 
        35                  40                  45              


Asn Lys Glu Tyr Lys Thr Arg Gln Ser Leu Val Tyr Ser Asn Leu Thr 
    50                  55                  60                  


Arg Tyr Met His Ile Ala Lys Val Phe Asp Phe Glu Lys Leu Pro Asp 
65                  70                  75                  80  


Asp Glu Arg Asp Lys Ala Glu Asn Tyr Gly Lys Asp Phe Gly Asn Leu 
                85                  90                  95      


Thr Asp Thr Leu Lys Glu Ile Phe Lys Glu Leu Asn Glu Phe Arg Asn 
            100                 105                 110         


Asp Tyr Ser His Tyr Tyr Ser Thr Glu Lys Lys Asp Lys Arg Lys Thr 
        115                 120                 125             


Ile Val Ser Asp Lys Leu Lys Asn Phe Leu Asn Ile Asn Tyr Thr Arg 
    130                 135                 140                 


Ala Ile Lys Tyr Thr Lys Ser Arg Phe Ile Asn Val Phe Ser Asp Asn 
145                 150                 155                 160 


Asn Phe Cys Leu Ala Glu Glu Ala Lys His Val Glu Asn Asp Asn Thr 
                165                 170                 175     


Ile Thr Gln Asp Gly Ile Val Phe Phe Thr Ser Met Phe Leu Asp Arg 
            180                 185                 190         


Glu Asn Ala Phe Gln Phe Ile Ser Lys Ile Ile Gly Leu Lys Gly Thr 
        195                 200                 205             


Gln Thr Lys Ala Phe Lys Ala Lys Arg Glu Thr Leu Met Ala Phe Cys 
    210                 215                 220                 


Val Asn Leu Pro His Asp Lys Phe Val Ser Glu Asn Ser Glu Gln Gln 
225                 230                 235                 240 


Phe Ser Leu Glu Leu Ile Asn Glu Leu Asn Lys Cys Pro Lys Thr Leu 
                245                 250                 255     


Tyr Asn Val Ile Ser Glu Asn Glu Lys Gln His Phe Leu Pro Lys Leu 
            260                 265                 270         


Asp Asp Glu Gln Ile Asp Asn Val Leu Glu Asn Ser Val Pro Tyr Thr 
        275                 280                 285             


Ile Asp Asp Tyr Glu Asn Tyr Ile Glu Asn Ile Thr Lys Lys Val Arg 
    290                 295                 300                 


Asn Lys Asn Arg Phe Ser Tyr Phe Ala Leu Lys Phe Ile Asp Gln Lys 
305                 310                 315                 320 


Lys Leu Phe Lys Asn Trp Arg Phe Gln Ile Asp Leu Gly Lys Ile Val 
                325                 330                 335     


Leu Asp Glu Tyr Ser Lys Gln Leu Asn Gly Lys Asp Glu Lys Arg Thr 
            340                 345                 350         


Val Thr Glu Asn Thr Lys Ala Phe Gly Met Leu Gln Asp Leu Asn Asp 
        355                 360                 365             


Glu Glu Asn Val Leu Asn Lys Ile Asn Thr Gly Glu Ser Lys Ala Lys 
    370                 375                 380                 


Phe Asp Gln Phe Ala Pro His Tyr Asn Phe Asp Val Gln Asn Asn Lys 
385                 390                 395                 400 


Ile Gly Ile Ser Lys Lys Glu Thr Thr Ala Lys Phe Ile Thr Lys Asn 
                405                 410                 415     


Thr Asp Asn Lys Ile Lys Ser Asn Leu Leu Gln Pro Leu Pro Glu Ala 
            420                 425                 430         


Phe Leu Ser Ile Asn Glu Leu Pro Lys Ile Ile Leu Leu Glu Tyr Leu 
        435                 440                 445             


Glu Gln Gly Lys Thr Glu Gln Leu Ile Asn Asp Phe Ile Glu Ile Asn 
    450                 455                 460                 


Asn Ser Lys Ile Leu Asn Lys Glu Phe Ile Lys Ala Ile Lys Leu Lys 
465                 470                 475                 480 


Leu Asn Asp Leu Asp Val Phe Tyr Lys Arg Ser Gln Gly Arg Lys Gln 
                485                 490                 495     


Lys His Ala Tyr Leu Thr Lys Asp Lys Lys Tyr Asp Asn Glu Lys Ile 
            500                 505                 510         


Asn Glu Leu Lys Asn Arg Lys Glu Lys Leu Asn Gln Ile Leu Ala Glu 
        515                 520                 525             


Tyr Asn Leu Asn Val Lys Gln Ile Pro Thr Arg Ile Leu Asp Tyr Trp 
    530                 535                 540                 


Leu Asn Ile Ala Asp Val Gln Ala Lys Asn Ala Ile Ser Asp Arg Ile 
545                 550                 555                 560 


Lys Leu Met Lys Arg Asp Cys Ile Asn Arg Leu Lys Ser Met Lys Lys 
                565                 570                 575     


Gly Lys Ala Pro Lys Ile Gly Glu Met Ala Thr Phe Ile Ala Lys Asp 
            580                 585                 590         


Ile Val Asp Met Ile Ile Asp Glu Glu Lys Lys Lys Lys Ile Thr Ser 
        595                 600                 605             


Phe Tyr Tyr Asp Lys Met Gln Glu Cys Leu Ala Leu Phe Ala Asp Lys 
    610                 615                 620                 


Glu Lys Lys Glu Leu Phe Ile Leu Ile Cys Asn Asn Glu Leu Lys Leu 
625                 630                 635                 640 


Asn Asp Asp Asp Gly His Pro Phe Phe Lys Asn Ile Asn Phe Ser Asn 
                645                 650                 655     


Tyr Lys Tyr Thr Ser Glu Ile Tyr Gln Lys Tyr Leu Glu Glu Lys Gly 
            660                 665                 670         


His Lys Met Val Lys Glu Tyr Asn Pro Arg Lys Glu Asn Tyr Val Glu 
        675                 680                 685             


Lys Asp Lys Ser Trp Leu Glu Ile Asn Phe Tyr Lys Lys Glu Trp Asn 
    690                 695                 700                 


Glu Asn Ala Lys Lys Asp Leu Thr Val Val Lys Leu Pro Asp Asp Lys 
705                 710                 715                 720 


Ser Lys Ile Pro Phe Thr Leu Arg Gln Leu Glu Lys Glu Lys Ser Ser 
                725                 730                 735     


Phe Glu Asn Trp Phe Lys Tyr Val Thr Asn Gly Lys Glu Thr Thr Asp 
            740                 745                 750         


Lys Lys Lys Pro Val Asp Leu Pro Val Asn Leu Phe Asp Glu Thr Leu 
        755                 760                 765             


Lys Glu Leu Leu Lys Lys Glu Leu Ser Lys Asn Asn Ile Glu Phe Lys 
    770                 775                 780                 


Glu Glu Asp Asn Tyr Asn Glu Leu Phe Lys Ile Trp Trp Asp Lys Cys 
785                 790                 795                 800 


Arg Asn Asp Lys Thr Gln Lys Phe Tyr Ser Ala Glu Arg Glu Tyr Thr 
                805                 810                 815     


Phe Glu Glu Glu Lys Leu Asn Phe His Ile Asn Thr Lys Ser Lys Phe 
            820                 825                 830         


Glu Glu Tyr Ile Asn Pro Glu Phe Ala Glu Lys Val Phe Arg Leu Lys 
        835                 840                 845             


Asn Gln Asn Arg Glu Lys Asp Asn Ile Ser Gly Arg Arg Leu Pro Pro 
    850                 855                 860                 


Leu Lys Met Lys Glu Val Thr Lys Asn Met Val Lys Arg Ile Gly Asn 
865                 870                 875                 880 


Thr Glu Lys Glu Ile Arg Met Leu Gln Glu Glu Asp Arg Leu Met Leu 
                885                 890                 895     


Leu Met Phe Glu Lys Leu Val Asp Asn Asn Leu Lys Leu Lys Leu Glu 
            900                 905                 910         


Asn Val Asp Lys Leu Leu Asn Glu Ser Ile Glu Ile Asn Gln Ser Ile 
        915                 920                 925             


Ser Gly Lys Leu Ser Phe Asp Asp Ser Gly Asp Asn Glu Asn Lys Lys 
    930                 935                 940                 


Asp Arg Ala Ile Ile Cys Arg Asn Ile Thr Glu Thr Arg Lys Arg Lys 
945                 950                 955                 960 


Glu Tyr Ser Val Leu Lys Lys Tyr Val Phe Asp Arg Arg Leu Pro Glu 
                965                 970                 975     


Leu Phe Glu Tyr Phe Glu Glu Glu Asn Ile Pro Ile Glu Lys Ile Lys 
            980                 985                 990         


Ile Glu Leu Asp Thr Tyr Ser Lys  Ala Lys Asp Val Val  Phe Asp Leu 
        995                 1000                 1005             


Ile Phe  Asp Leu Glu Arg Ala  Ile Ile Asn Lys Asp  Glu Asn Arg 
    1010                 1015                 1020             


Ile Lys  Glu Leu Asn Lys Asp  Lys Asn Gly Val Ile  Gln Thr Gly 
    1025                 1030                 1035             


Asn Ile  Gln His Lys Pro Tyr  Leu Phe Trp Leu Leu  Glu Lys Asn 
    1040                 1045                 1050             


Leu Ile  Thr Glu Gln Glu Phe  Thr Phe Met Asn Met  Val Arg Asn 
    1055                 1060                 1065             


Thr Phe  Ser His Asn Gln Phe  Pro Gln Lys Lys Thr  Met Glu Leu 
    1070                 1075                 1080             


Phe Ile  Lys Asn Trp Asn Glu  Asn Glu Phe Ala Lys  Gln Ile Leu 
    1085                 1090                 1095             


Asn Val  Tyr Asn Gln Lys Asn  Asn Asn Leu Ile Lys  Ser Ile Lys 
    1100                 1105                 1110             


Asp Ile  
    1115 


<210>  2765
<211>  947
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2765

Met Tyr Lys Val Phe Asp Ala Asn Val Arg Leu Val Lys Arg Asp Tyr 
1               5                   10                  15      


Met His His Glu Asn Ile Asp Met Gln Arg Asp Phe Thr His Leu Asn 
            20                  25                  30          


Arg Lys Lys Gln Val Gly Arg Thr Arg Lys Ile Ile Ala Asn Pro Asn 
        35                  40                  45              


Phe Arg Tyr His Phe Ala Asp Glu Lys Gly Asn Met Thr Ile Thr Gly 
    50                  55                  60                  


Leu Leu Phe Phe Ile Ser Leu Phe Leu Asp Lys Lys Asp Ala Ile Trp 
65                  70                  75                  80  


Met Gln Lys Lys Leu Lys Gly Phe Lys Asp Gly Arg Asn Leu Arg Glu 
                85                  90                  95      


Gln Met Thr Asn Glu Val Phe Cys Arg Ser Arg Ile Ser Leu Pro Lys 
            100                 105                 110         


Leu Lys Leu Glu Asn Val Gln Thr Lys Asp Trp Met Gln Leu Asp Met 
        115                 120                 125             


Leu Asn Glu Leu Val Arg Cys Pro Lys Ser Leu Tyr Glu Arg Leu Arg 
    130                 135                 140                 


Glu Lys Asp Arg Glu Ser Phe Lys Val Pro Phe Asp Ile Phe Ser Asp 
145                 150                 155                 160 


Asp Tyr Asp Ala Glu Glu Glu Pro Phe Lys Asn Thr Leu Val Arg His 
                165                 170                 175     


Gln Asp Arg Phe Pro Tyr Phe Val Leu Arg Tyr Phe Asp Leu Asn Glu 
            180                 185                 190         


Ile Phe Glu Gln Leu Arg Phe Gln Ile Asp Leu Gly Thr Tyr His Phe 
        195                 200                 205             


Ser Ile Tyr Asn Lys Leu Ile Gly Asp Glu Asp Glu Val Arg His Leu 
    210                 215                 220                 


Thr His His Leu Tyr Gly Phe Ala Arg Ile Gln Asp Phe Ala Pro Gln 
225                 230                 235                 240 


Asn Gln Pro Glu Glu Trp Arg Lys Leu Val Lys Asp Leu Asp His Phe 
                245                 250                 255     


Glu Thr Ser Gln Lys Pro Tyr Ile Ser Lys Thr Ala Pro His Tyr His 
            260                 265                 270         


Leu Glu Asn Glu Lys Ile Gly Ile Lys Phe Cys Ser Thr His Asn Asn 
        275                 280                 285             


Leu Phe Pro Ser Leu Lys Arg Glu Lys Thr Cys Asn Gly Arg Ser Lys 
    290                 295                 300                 


Phe Asn Leu Gly Thr Gln Phe Thr Ala Glu Ala Phe Leu Ser Val His 
305                 310                 315                 320 


Glu Leu Leu Pro Met Met Phe Tyr Tyr Leu Leu Leu Thr Lys Asp Tyr 
                325                 330                 335     


Ser Arg Lys Glu Ser Ala Asp Lys Val Glu Gly Ile Ile Arg Lys Glu 
            340                 345                 350         


Ile Ser Asn Ile Tyr Ala Ile Tyr Asp Ala Phe Ala Asn Asn Glu Ile 
        355                 360                 365             


Asn Ser Ile Ala Asp Leu Thr Cys Arg Leu Gln Lys Thr Asn Ile Leu 
    370                 375                 380                 


Gln Gly His Leu Pro Lys Gln Met Ile Ser Ile Leu Glu Gly Arg Gln 
385                 390                 395                 400 


Lys Asp Met Glu Lys Glu Ala Glu Arg Lys Ile Gly Glu Met Ile Asp 
                405                 410                 415     


Asp Thr Gln Arg Arg Leu Asp Leu Leu Cys Lys Gln Thr Asn Gln Lys 
            420                 425                 430         


Ile Arg Ile Gly Lys Arg Asn Ala Gly Leu Leu Lys Ser Gly Lys Ile 
        435                 440                 445             


Ala Asp Trp Leu Val Ser Asp Met Met Arg Phe Gln Pro Val Gln Lys 
    450                 455                 460                 


Asp Thr Asn Asn Ala Pro Ile Asn Asn Ser Lys Ala Asn Ser Thr Glu 
465                 470                 475                 480 


Tyr Arg Met Leu Gln His Ala Leu Ala Leu Phe Gly Ser Glu Ser Ser 
                485                 490                 495     


Arg Leu Lys Ala Tyr Phe Arg Gln Met Asn Leu Val Gly Asn Ala Asn 
            500                 505                 510         


Pro His Pro Phe Leu Ala Glu Thr Gln Trp Glu His Gln Thr Asn Ile 
        515                 520                 525             


Leu Ser Phe Tyr Arg Asn Tyr Leu Glu Ala Arg Lys Lys Tyr Leu Lys 
    530                 535                 540                 


Gly Leu Lys Pro Gln Asn Trp Lys Gln Tyr Gln His Phe Leu Ile Leu 
545                 550                 555                 560 


Lys Val Gln Lys Thr Asn Arg Asn Thr Leu Val Thr Gly Trp Lys Asn 
                565                 570                 575     


Ser Phe Asn Leu Pro Arg Gly Ile Phe Thr Gln Pro Ile Arg Glu Trp 
            580                 585                 590         


Phe Glu Lys His Asn Asn Ser Lys Arg Ile Tyr Asp Gln Ile Leu Ser 
        595                 600                 605             


Phe Asp Arg Val Gly Phe Val Ala Lys Ala Ile Pro Leu Tyr Phe Ala 
    610                 615                 620                 


Glu Glu Tyr Lys Asp Asn Val Gln Pro Phe Tyr Asp Tyr Pro Phe Asn 
625                 630                 635                 640 


Ile Gly Asn Lys Leu Lys Pro Gln Lys Gly Gln Phe Leu Asp Lys Lys 
                645                 650                 655     


Glu Arg Val Glu Leu Trp Gln Lys Asn Lys Glu Leu Phe Lys Asn Tyr 
            660                 665                 670         


Pro Ser Glu Lys Lys Lys Thr Asp Leu Ala His Leu Asp Phe Leu Ser 
        675                 680                 685             


Trp Lys Lys Phe Glu Arg Glu Leu Arg Leu Ile Lys Asn Gln Asp Ile 
    690                 695                 700                 


Val Thr Trp Leu Met Phe Lys Glu Leu Phe Lys Thr Thr Thr Val Glu 
705                 710                 715                 720 


Gly Leu Lys Ile Gly Glu Ile His Leu Arg Asp Ile Asp Thr Asn Thr 
                725                 730                 735     


Ala Asn Glu Glu Ser Asn Asn Ile Leu Asn Arg Ile Met Pro Met Lys 
            740                 745                 750         


Leu Pro Val Lys Thr Tyr Glu Thr Asp Asn Lys Gly Asn Ile Leu Lys 
        755                 760                 765             


Glu Arg Pro Leu Ala Thr Phe Tyr Ile Glu Glu Thr Glu Thr Lys Val 
    770                 775                 780                 


Leu Lys Gln Gly Asn Phe Lys Val Leu Ala Lys Asp Arg Arg Leu Asn 
785                 790                 795                 800 


Gly Leu Leu Ser Phe Ala Glu Thr Thr Asp Ile Asp Leu Glu Lys Asn 
                805                 810                 815     


Pro Ile Thr Lys Leu Ser Val Asp His Glu Leu Ile Lys Tyr Gln Thr 
            820                 825                 830         


Thr Arg Ile Ser Ile Phe Glu Met Thr Leu Gly Leu Glu Lys Lys Leu 
        835                 840                 845             


Ile Asp Lys Tyr Ser Thr Leu Pro Thr Asp Ser Phe Arg Asn Met Leu 
    850                 855                 860                 


Glu Arg Trp Leu Gln Cys Lys Ala Asn Arg Pro Glu Leu Lys Asn Tyr 
865                 870                 875                 880 


Val Asn Ser Leu Ile Ala Val Arg Asn Ala Phe Ser His Asn Gln Tyr 
                885                 890                 895     


Pro Met Tyr Asp Ala Thr Leu Phe Ala Glu Val Lys Lys Phe Thr Leu 
            900                 905                 910         


Phe Pro Ser Val Asp Thr Lys Lys Ile Glu Leu Asn Ile Ala Pro Gln 
        915                 920                 925             


Leu Leu Glu Ile Val Gly Lys Ala Ile Lys Glu Ile Glu Lys Ser Glu 
    930                 935                 940                 


Asn Lys Asn 
945         


<210>  2766
<211>  994
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2766

Met Asp Ser Lys Tyr Ile Leu Gly Ser Tyr Leu Asn Met Ala Asn Asp 
1               5                   10                  15      


Asn Phe Ile Asn Thr Ile His Leu Leu Ala Lys Lys Leu Lys Thr Pro 
            20                  25                  30          


Lys Gly Glu Asp Gln Asn Leu Asp Gln Val Val Ser Tyr Ile Pro Arg 
        35                  40                  45              


Ile Phe Asp Asn Ser Asn Gln Val Pro Glu Thr Glu Gln Ile Val Glu 
    50                  55                  60                  


Phe Tyr Phe Pro Trp Leu Glu Ala Leu Lys Asn Ala Asn Gly Phe Gly 
65                  70                  75                  80  


Lys Ser Glu Leu Pro Glu Leu Lys Ile Phe Tyr Lys Asp Val Leu Cys 
                85                  90                  95      


Ser Phe Ala Glu Asn Leu Lys Asp Leu Arg Asn Asn Tyr Thr His Tyr 
            100                 105                 110         


Ile His Lys Thr Ile Ser Tyr His Pro Ile Ile Tyr Lys Lys Glu Gly 
        115                 120                 125             


Asn Thr Leu Gln Cys Ser Leu Pro Lys Ala Leu Leu Gln Ile Tyr Asp 
    130                 135                 140                 


Thr Ser Ile Lys Leu Ala Lys Glu Arg Phe Ser Ala Asp Glu Asn Ala 
145                 150                 155                 160 


Val Thr His Leu Arg Arg Tyr Lys Met Val Gly Lys Lys Val Val Arg 
                165                 170                 175     


Lys Thr Glu Ala Asp His Phe Met Tyr Ser Leu Glu Lys Asp His Leu 
            180                 185                 190         


Leu Thr Glu Lys Gly Ile Ala Phe Phe Thr Ser Leu Phe Leu Asn Arg 
        195                 200                 205             


Lys Tyr Gly Tyr Leu Met Leu Lys Gln Leu Lys Gly Phe Lys Gln Gly 
    210                 215                 220                 


Gly Thr Leu Ala Tyr Arg Leu Thr Leu Glu Thr Phe Leu Ala Tyr Ser 
225                 230                 235                 240 


Asn Ile Lys Pro Val Glu Arg Leu Lys Ala Asp Lys Tyr Ser Asp Val 
                245                 250                 255     


Ala Phe Ile Met Asp Leu Leu Gly Glu Ile Ser Lys Ile Pro Lys Glu 
            260                 265                 270         


Leu Tyr His Ile Leu Pro Glu Thr Tyr Ile Leu Gln Tyr Lys Asn Lys 
        275                 280                 285             


Leu His Ile Glu Leu Asn Glu Asp Ile Ser Leu Glu Ala Tyr Cys Ser 
    290                 295                 300                 


Arg Gly Arg Asn Arg Phe Asp Gln Leu Ala Leu Thr Tyr Leu Asp Arg 
305                 310                 315                 320 


Leu Glu Asp Phe Lys Gln Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr 
                325                 330                 335     


Ile His Asn Gly Tyr Met Lys Val Arg Ile Asp Gly Thr Glu Gln Glu 
            340                 345                 350         


Arg Tyr Leu Ser Glu Lys Met Tyr Gly Cys Cys Lys Asn Ile Tyr Arg 
        355                 360                 365             


Asp Leu Ser Ala Ile Val Ala Lys Gln Tyr Asn Ile Lys Val Lys Asp 
    370                 375                 380                 


Ser Thr Glu Thr Ser Tyr Met Leu Pro Asn Asp Phe Gln Pro His Val 
385                 390                 395                 400 


Ile Arg Ala Tyr Pro His Tyr Val Ile Asn Asn Asn Asn Ile Gly Ile 
                405                 410                 415     


Arg Leu Leu Asp Glu Gly Glu Ser Gly Phe Pro Ile Leu Glu Asn Arg 
            420                 425                 430         


Gly Thr Lys Asn Val Val Pro His Phe Trp Met Ser Lys Tyr Asp Leu 
        435                 440                 445             


Pro Ala Leu Leu Phe Tyr Ala Tyr Leu Arg Ser Asp Ser Arg Phe Ala 
    450                 455                 460                 


Ser Lys Cys Lys Lys Thr Ile Asp Glu Ile Leu Arg Gly Tyr Leu Ser 
465                 470                 475                 480 


Lys Ser Lys Asp Lys Lys Pro Lys Gln Ala Glu Lys Val Ser Val Leu 
                485                 490                 495     


Met Leu Arg Arg Ile Asp Lys Ala Ile Ile Trp Thr Gln Thr Lys Leu 
            500                 505                 510         


Asn Glu Ala Glu Lys Gln Arg Asp Asn Lys Lys Ser Phe Lys Ile Gly 
        515                 520                 525             


Glu Lys Ala Asp Ile Leu Ala His Asp Met Leu Trp Leu Gln Pro Ala 
    530                 535                 540                 


Lys Glu Ser Lys Asp Lys Val Ser Gly Ala Asn Phe Arg Ala Leu Gln 
545                 550                 555                 560 


Thr Ser Leu Ala Phe Phe Lys Arg Asn Glu Leu Glu Asp Ile Phe Lys 
                565                 570                 575     


Arg Ser Phe Leu Ile Gly Gly Asn Asn Pro His Pro Phe Leu Ser Arg 
            580                 585                 590         


Ile Lys Ile Asn Thr Met Pro Ser Leu Phe Asp Phe Tyr Leu Ala Tyr 
        595                 600                 605             


Met Arg Glu Arg Leu Asn Tyr Trp Glu Lys Ile Lys Leu Lys Leu Leu 
    610                 615                 620                 


Lys Gly His Ile Asn Val Ser Cys His Pro Leu Arg Lys Leu Asn His 
625                 630                 635                 640 


Gly Lys Pro Val Asp Gln Asp Asn Lys Lys Asp Glu Gln Pro Ile Phe 
                645                 650                 655     


Leu Pro Arg Gly Ile Phe Asn Asp Val Ile Lys Asn Cys Leu Gln Lys 
            660                 665                 670         


Thr Lys Leu Gly Ile Tyr Leu Lys Asp Gln Gly Val Glu Thr Arg Ser 
        675                 680                 685             


Trp Asn Val Ala Tyr Gln Ile Leu Lys Phe His Glu Ile Ile Asn Asp 
    690                 695                 700                 


Asp Asp Ile Gln Glu Phe Tyr Lys Gln Pro Arg Lys Tyr Ala Ile Leu 
705                 710                 715                 720 


Asp Glu Asn His Tyr Leu Thr Leu Glu Glu Arg Thr Asp Arg Leu Lys 
                725                 730                 735     


Asp Leu Lys Pro Glu Cys Ile Glu Val Ser Lys Ala Asn Asp Ile Leu 
            740                 745                 750         


Glu Lys Glu Asp Tyr Leu Leu Arg Lys Ser Tyr Asn Gln Val Cys Asp 
        755                 760                 765             


Asn Glu Ser Ala Ile Arg Leu Tyr Gln Val Gln Asp Ile Leu Leu Phe 
    770                 775                 780                 


Met Ile Ala Gln Arg Leu Cys Asn Glu Ile Ile Leu Gly Asp Lys Gln 
785                 790                 795                 800 


Glu Lys Lys Glu Lys Ile Val Thr Ser Phe Ser Leu Thr Leu Lys Asn 
                805                 810                 815     


Leu Ser Lys Lys Phe Asp Gln Pro Val His Phe Glu Ile Lys Met Asn 
            820                 825                 830         


Asn Val Asp Leu Phe Ser Asp Thr Asp Phe Pro Val Lys Asn Phe Gly 
        835                 840                 845             


Lys Met Leu Arg Leu Lys Lys Asp Ala Arg Phe Ile Ser Tyr Asp Lys 
    850                 855                 860                 


Leu Phe Lys Gly Gln Lys Gln Asn Ile Asn Tyr Asn Asp Tyr Cys Lys 
865                 870                 875                 880 


Glu Glu Glu Tyr Phe Asp Ile Cys Arg Ile Gln Met Val Lys Leu Cys 
                885                 890                 895     


His Glu Leu Glu Glu Lys Leu Leu Glu Lys Gly Ile Ile Thr Glu Ser 
            900                 905                 910         


Pro Asn Ser Gly Tyr Tyr Pro Phe Ala Asp Leu Val Gln Arg Ile Ile 
        915                 920                 925             


Asn Gln Gly Val Val Ile Ser Ser Ser Asp Val Lys Phe Ile Leu Glu 
    930                 935                 940                 


Ala Arg Asn Met Phe Leu His Asn Glu Tyr Lys Gln Tyr Cys Val Asn 
945                 950                 955                 960 


Ser Ile Asn Ser Ile Asp Ser Phe Ile Ala Glu Lys Val Tyr Asn Leu 
                965                 970                 975     


Phe Lys Gln Lys Met Asp Asn Ile Leu Gly Gln Leu Glu Ser Ile Lys 
            980                 985                 990         


Pro Ser 
        


<210>  2767
<211>  916
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2767

Met Glu Ser Ile Ile Gly Leu Gly Leu Ser Phe Asn Pro Tyr Lys Thr 
1               5                   10                  15      


Ala Asp Lys His Tyr Phe Gly Ser Phe Leu Asn Leu Ala Asp Asn Asn 
            20                  25                  30          


Leu Lys Ala Val Phe Ala Glu Phe Lys Glu Arg Ile Ser Asp Lys Ser 
        35                  40                  45              


Lys Asp Glu Asp Ile Ser Asn Leu Ile Glu Lys His Phe Ile Asp Asn 
    50                  55                  60                  


Met Ser Ile Val Asp Tyr Glu Lys Asn Ile Ser Ile Leu Asn Gly Tyr 
65                  70                  75                  80  


Leu Pro Ile Ile Asp Phe Leu Asp Asp Glu Leu Glu Asn Asn Leu Asn 
                85                  90                  95      


Thr Arg Val Lys Asn Phe Lys Lys Ser Phe Ile Ile Leu Ala Glu Ala 
            100                 105                 110         


Leu Glu Thr Leu Arg Asn Tyr Tyr Thr His Phe Tyr His Asp Pro Ile 
        115                 120                 125             


Thr Phe Gly Asp Asn Lys Glu Pro Leu Leu Glu Leu Leu Asp Glu Val 
    130                 135                 140                 


Leu Leu Lys Thr Ile Leu Asp Val Lys Lys Lys Tyr Leu Lys Thr Asp 
145                 150                 155                 160 


Lys Thr Lys Glu Ile Leu Lys Asp Ser Leu Arg Glu Glu Met Asp Leu 
                165                 170                 175     


Leu Val Ile Arg Lys Thr Asp Glu Leu Arg Glu Lys Lys Lys Thr Asn 
            180                 185                 190         


Pro Lys Phe Lys Phe Ser Thr Asp Pro Thr Gln Ile Arg Asn Ser Ile 
        195                 200                 205             


Phe Asn Asp Ala Phe Gln Gly Leu Leu Tyr Glu Asp Lys Glu Asn Asn 
    210                 215                 220                 


Gly Lys Thr Gln Val Ser Tyr Arg Ala Lys Thr Lys Leu Asn Pro Lys 
225                 230                 235                 240 


Asp Ile His Lys Gln Glu Glu Arg Asp Phe Glu Ile Pro Leu Ser Thr 
                245                 250                 255     


Ser Gly Ile Val Phe Leu Met Ser Leu Phe Leu Ser Lys Lys Glu Ile 
            260                 265                 270         


Glu Asp Phe Lys Ser Asn Ile Lys Gly Phe Lys Gly Lys Val Val Lys 
        275                 280                 285             


Asp Glu Asn His Asn Ser Leu Lys Tyr Met Ala Thr His Arg Val Tyr 
    290                 295                 300                 


Ser Ile Leu Ala Phe Lys Gly Leu Lys Tyr Arg Ile Lys Thr Asp Thr 
305                 310                 315                 320 


Phe Ser Lys Val Thr Leu Met Met Gln Met Ile Asp Glu Leu Ser Lys 
                325                 330                 335     


Val Pro Asp Cys Val Tyr Gln Asn Leu Ser Glu Thr Lys Gln Lys Asp 
            340                 345                 350         


Phe Ile Glu Asp Trp Asn Glu Tyr Leu Lys Asp Asn Glu Glu Asn Thr 
        355                 360                 365             


Glu Asn Leu Glu Asn Ser Arg Val Val His Pro Leu Ile Arg Lys Arg 
    370                 375                 380                 


Tyr Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe 
385                 390                 395                 400 


Ala Asn Phe Lys Thr Leu Lys Phe Gln Val Phe Met Gly Tyr Tyr Ile 
                405                 410                 415     


His Asp Gln Arg Thr Lys Thr Ile Gly Thr Thr Asn Ile Thr Thr Glu 
            420                 425                 430         


Arg Thr Val Lys Glu Lys Ile Asn Val Phe Gly Lys Leu Ser Lys Met 
        435                 440                 445             


Asp Asn Leu Lys Lys His Phe Phe Ser Gln Leu Ser Asp Glu Glu Asn 
    450                 455                 460                 


Thr Asp Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Phe Leu Thr Gln 
465                 470                 475                 480 


Ala Asp Asn Ser Pro Ala Asn Asn Ile Pro Ile Tyr Leu Glu Leu Lys 
                485                 490                 495     


Asn Gln Gln Ile Ile Lys Glu Lys Asp Asp Ile Lys Ala Glu Val Asn 
            500                 505                 510         


Asn Ser Gln Asn Arg Asn Pro Asn Lys Pro Ser Lys Arg Asp Leu Leu 
        515                 520                 525             


Asn Lys Ile Ser Asn Thr Asn Glu Asp Phe Tyr Gln Gly Asp Pro Thr 
    530                 535                 540                 


Ala Ile Leu Ser Leu Asn Glu Ile Pro Ala Leu Leu His Leu Phe Leu 
545                 550                 555                 560 


Val Gln Pro Asp Asn Lys Thr Gly Gln Gln Ile Glu Asn Ile Ile Arg 
                565                 570                 575     


Ile Lys Ile Glu Lys Gln Phe Asn Ser Ile Lys Asn Pro Ser Lys Asp 
            580                 585                 590         


Asp Lys Gly Val Pro Lys Ser Leu Phe Ala Asp Thr Asn Val Arg Val 
        595                 600                 605             


Asn Ala Ile Lys Leu Lys Lys Asp Leu Gly Glu Glu Leu Asp Met Leu 
    610                 615                 620                 


Asn Lys Lys Gln Ile Val Phe Lys Glu Asn Gln Lys Ala Ser Ser Asn 
625                 630                 635                 640 


Tyr Asp Glu Leu Leu Lys Lys His Gln Phe Thr Pro Lys Asn Lys Arg 
                645                 650                 655     


Pro Ala Leu Arg Lys Tyr Val Phe Tyr Asn Ser Glu Lys Gly Glu Glu 
            660                 665                 670         


Ala Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Lys Gly Phe 
        675                 680                 685             


Lys Thr Lys Trp Lys Gly Tyr Gln His Ser Glu Leu Gln Arg Lys Leu 
    690                 695                 700                 


Ala Phe Tyr Asp Arg His Thr Lys Gln Asp Ile Lys Glu Leu Leu Ser 
705                 710                 715                 720 


Gly Cys Glu Phe Asp His Phe Leu Leu Asp Ile Asn Ala Cys Phe Lys 
                725                 730                 735     


Glu Asp Asp Phe Glu Asp Phe Phe Ser Lys Tyr Leu Lys Asn Arg Ile 
            740                 745                 750         


Glu Thr Leu Asn Ile Ile Leu Lys Gln Leu His Asp Phe Lys Asn Glu 
        755                 760                 765             


Pro Thr Pro Leu Lys Gly Val Phe Lys Asn Cys Leu Lys Phe Leu Lys 
    770                 775                 780                 


Gln Lys Asn Tyr Val Thr Glu Asn Pro Glu Ile Ile Lys Lys Arg Ile 
785                 790                 795                 800 


Leu Ala Lys Pro Ala Phe Leu Pro Arg Gly Ile Phe Asp Glu Arg Pro 
                805                 810                 815     


Thr Met Lys Lys Gly Lys Asn Pro Leu Ile Asp Arg Asp Glu Phe Ala 
            820                 825                 830         


Lys Trp Phe Val Glu Tyr Leu Glu Asn Lys Asp Tyr Gln Lys Phe Tyr 
        835                 840                 845             


Asn Ser Glu Glu Tyr Arg Ile Arg Asp Ala Asp Phe Lys Lys Asn Ala 
    850                 855                 860                 


Val Ile Lys Lys Gln Lys Leu Lys Asp Phe Tyr Thr Leu Gln Met Val 
865                 870                 875                 880 


Asn Tyr Leu Leu Lys Glu Val Phe Gly Lys Asp Glu Met Asn Leu Gln 
                885                 890                 895     


Leu Ser Glu Leu Phe Gln Thr Arg Gln Glu Arg Leu Lys Leu Gln Gly 
            900                 905                 910         


Ile Ala Lys Pro 
        915     


<210>  2768
<211>  909
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2768

Met Gly Ala Ile Lys Asn Lys His Ile Phe Ala Ala Tyr Ala Asn Leu 
1               5                   10                  15      


Ala Ile Asp Gly Leu Ile Lys Thr Leu Asn Phe Ile Ala Lys Lys Leu 
            20                  25                  30          


Asp Thr Gln Lys Gln Leu Ser Ser Trp Asp Ile Lys His Val Ile Thr 
        35                  40                  45              


Leu Ile Asp Ser Ile Phe Asp Gln Asn Pro Gln Asn Asn Leu Glu Gln 
    50                  55                  60                  


Val Val Glu Gly Tyr Leu Pro Trp Ile Lys Pro Ile Ile Glu Met Lys 
65                  70                  75                  80  


Thr Pro Lys Lys Gly Glu Arg Gln Ser Asp Lys Leu Cys Ile Glu Tyr 
                85                  90                  95      


Lys Thr Ile Ile Thr Ala Phe Ala Ser Leu Leu Asn Asp Val Arg Asn 
            100                 105                 110         


Tyr Tyr Thr His Tyr Tyr His Asp Pro Ile Cys Ile Tyr Pro Gly Gly 
        115                 120                 125             


Tyr Asp Ile Pro Ser Ser Leu Asn Cys Ile Tyr Asp Ser Ala Ile Asn 
    130                 135                 140                 


Ile Ile Lys Glu Arg Phe Gln Ala Glu Glu Lys Glu Met Glu His Leu 
145                 150                 155                 160 


Arg Arg Tyr Thr Arg Lys Lys Gly Arg Val Val Leu Lys Thr Glu Asp 
                165                 170                 175     


Asp His Phe Tyr Tyr Thr Leu Ala Asn Asn Asn Asp Leu Ser Glu Lys 
            180                 185                 190         


Gly Tyr Ala Phe Phe Ile Ser Met Phe Leu Glu Arg Lys Tyr Ser Tyr 
        195                 200                 205             


Leu Phe Leu Lys Lys Leu Ser Gly Phe Lys Arg Gly Asp Ser Leu Gln 
    210                 215                 220                 


Tyr Arg Leu Thr Leu Glu Val Phe Thr Ala Leu Ser Thr Lys Pro Pro 
225                 230                 235                 240 


Val Glu Arg Leu Arg Thr Thr Lys Asp Thr Lys Gln Asp Arg Ala Leu 
                245                 250                 255     


Asp Ile Leu Asn Glu Leu Ser Lys Ile Pro Ile Glu Leu Tyr Gln Thr 
            260                 265                 270         


Leu Glu Pro Lys Tyr Arg Glu Met Tyr Asn Glu Thr Leu Gln Pro Thr 
        275                 280                 285             


Asp Ala Glu Asp Pro Tyr Gly Leu Pro Asp Arg Ser Arg Ile Arg Phe 
    290                 295                 300                 


Arg Ser Arg Phe Glu Ala Phe Ala Leu His Phe Leu Asp Lys Gln Ala 
305                 310                 315                 320 


Asp Phe Lys Glu Ile Gly Phe Tyr Thr Tyr Leu Gly Asn Tyr Phe His 
                325                 330                 335     


Asn Gly Tyr Gln Lys Thr Arg Val Asp Arg Glu Thr Lys Asp Arg Tyr 
            340                 345                 350         


Ile Asn Phe Gln Leu Ala Gly Phe Cys Lys Asn Ile Gln Asp Ile Ser 
        355                 360                 365             


Ala Lys Lys Leu Ser Glu Ala Leu Asn Val Lys Ser Ile Asp Ile Ser 
    370                 375                 380                 


Thr Asp Ser Ile Pro Asp Ile Asn Ser Phe Glu Pro Tyr Leu Val Gln 
385                 390                 395                 400 


Ser Thr Pro His Tyr Ile Val Asn Gly Asn Asn Ile Gly Ile Lys Val 
                405                 410                 415     


Leu Pro Glu Gly Lys Asp Thr Tyr Pro Thr Ile Asp Glu Lys Gly Ala 
            420                 425                 430         


Lys Met Pro Ile Ala Asp Phe Trp Leu Ser Lys Tyr Glu Leu Pro Ala 
        435                 440                 445             


Met Leu Phe Tyr Thr Tyr Leu Arg Asn Asn Asn Ile His Lys Ser His 
    450                 455                 460                 


Cys Pro Leu Ser Val Lys Asp Ile Ile Glu Arg Ser Ile His Lys Ser 
465                 470                 475                 480 


Thr Lys Gln Lys His Pro Glu Glu Arg Ser Glu Leu Met Leu Arg Arg 
                485                 490                 495     


Val Met Lys Ala Ile Phe Trp Thr Asp Ser Lys Leu Asn Glu Val Glu 
            500                 505                 510         


Arg Ile Lys Ser Gln Lys Ser Ala Phe Gly Lys Arg Gln His Glu Ile 
        515                 520                 525             


Leu Lys Ala Gly Arg Ile Ala Glu Thr Leu Val Arg Asp Met Leu Trp 
    530                 535                 540                 


Leu Gln Pro Ser Lys Asn Asn Gly Arg Asp Lys Val Thr Glu Pro Asn 
545                 550                 555                 560 


Phe Gln Ala Ile Gln Val Ser Leu Ala Tyr Phe Gly Ile Arg Arg Asn 
                565                 570                 575     


Asp Leu Thr Glu Ile Phe Thr Arg Ala Gly Leu Ile Asn Ser Ser Asn 
            580                 585                 590         


Pro His Pro Phe Leu Ala Gln Ile Gly Thr Asn Tyr Thr Ser Leu Ile 
        595                 600                 605             


Glu Phe Tyr Ile Ala Tyr Leu Lys Glu Arg Lys Val Tyr Phe Ser Arg 
    610                 615                 620                 


Ile Gln Lys Lys Ile Leu Gln Gly Lys Leu Asn Ile Gln Cys His Pro 
625                 630                 635                 640 


Leu Arg Asp Leu Gln Arg Glu Pro Asn Lys Pro Gln Asp Lys Glu Glu 
                645                 650                 655     


Ala Ile Phe Leu Pro Arg Gly Leu Phe Asn Glu Ala Ile Ile Asn Cys 
            660                 665                 670         


Leu Lys Lys Ser Lys Leu Lys Gln Leu Ile Glu Ser Pro Thr Arg Glu 
        675                 680                 685             


Lys Ser Pro Ala Leu Asn Val Ser Tyr Leu Ile Gln Asn Tyr Phe Arg 
    690                 695                 700                 


Thr Tyr Phe Glu Asp Gln Ser Gln Glu Phe Tyr Ala Gln Pro Arg Asn 
705                 710                 715                 720 


Tyr Arg Leu Phe Asp Lys Leu Ser Pro Asn Lys Gly Lys Ser Lys Ser 
                725                 730                 735     


Tyr Leu Ser Leu Glu Gln Arg Ile Lys Lys Met Glu Glu Leu Arg Pro 
            740                 745                 750         


Ser Lys Ile Pro Val Ala Glu Ala Asn Lys Leu Leu Glu Lys Glu Asp 
        755                 760                 765             


Arg Leu Tyr Arg Lys Asn Tyr Asn Glu Ile Cys Asp Asn Glu Ser Ile 
    770                 775                 780                 


Ile Arg Leu Tyr Gln Ile Gln Asp Ile Leu Leu Phe Met Met Thr Lys 
785                 790                 795                 800 


Glu Tyr Leu Pro Ser Asp Leu Tyr Asn Arg Ile Asn Lys Tyr Lys Leu 
                805                 810                 815     


Glu Asn Val Lys Gly Ile Leu Asn Glu Arg Val Ser Tyr Leu Ile Asp 
            820                 825                 830         


Leu Asn Pro Leu Lys Ile Gln Gly Glu Asp Ile Lys Ile Lys Asp Tyr 
        835                 840                 845             


Gly Lys Leu Phe Tyr Ile His His Asp Thr Arg Ile Ser Ser Leu Asn 
    850                 855                 860                 


Lys Val Leu Ser Lys Val Lys Arg Asn Asn Ser Ile Ser Ser Ser Val 
865                 870                 875                 880 


Lys Ile Gln Pro Tyr Glu Asn Tyr Lys Arg Glu Cys Leu Asp Phe Glu 
                885                 890                 895     


Glu Ala Gln Ile Gln Ile Ile Pro Ile Ile His Ser Phe 
            900                 905                 


<210>  2769
<211>  916
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2769

Met Glu Ser Ile Ile Gly Leu Gly Leu Ser Phe Asn Pro Tyr Lys Thr 
1               5                   10                  15      


Ala Asp Lys His Tyr Phe Gly Ser Phe Leu Asn Leu Ala Asp Asn Asn 
            20                  25                  30          


Leu Lys Ala Val Phe Ala Glu Phe Lys Glu Arg Ile Ser Asp Lys Ser 
        35                  40                  45              


Lys Asp Glu Asp Ile Ser Asn Leu Ile Glu Lys His Phe Ile Asp Asn 
    50                  55                  60                  


Met Ser Ile Val Asp Tyr Glu Lys Asn Ile Ser Ile Leu Asn Gly Tyr 
65                  70                  75                  80  


Leu Pro Ile Ile Asp Phe Leu Asp Asp Glu Leu Glu Asn Asn Leu Asn 
                85                  90                  95      


Thr Arg Val Lys Asn Phe Lys Lys Ser Phe Ile Ile Leu Ala Glu Ala 
            100                 105                 110         


Leu Glu Thr Leu Arg Asn Tyr Tyr Thr His Phe Tyr His Asp Pro Ile 
        115                 120                 125             


Thr Phe Gly Asp Asn Lys Glu Pro Leu Leu Glu Leu Leu Asp Glu Val 
    130                 135                 140                 


Leu Leu Lys Thr Ile Leu Asp Val Lys Lys Lys Tyr Leu Lys Thr Asp 
145                 150                 155                 160 


Lys Thr Lys Glu Ile Leu Lys Asp Ser Leu Arg Glu Glu Met Asp Leu 
                165                 170                 175     


Leu Val Ile Arg Lys Thr Asp Glu Leu Arg Glu Lys Lys Lys Thr Asn 
            180                 185                 190         


Pro Lys Phe Lys Phe Ser Thr Asp Pro Thr Gln Ile Arg Asn Ser Ile 
        195                 200                 205             


Phe Asn Asp Ala Phe Gln Gly Leu Leu Tyr Glu Asp Lys Glu Asn Asn 
    210                 215                 220                 


Gly Lys Thr Gln Val Ser Tyr Arg Ala Lys Thr Lys Leu Asn Pro Lys 
225                 230                 235                 240 


Asp Ile His Lys Gln Glu Glu Arg Asp Phe Glu Ile Pro Leu Ser Thr 
                245                 250                 255     


Ser Gly Ile Val Phe Leu Met Ser Leu Phe Leu Ser Lys Lys Glu Ile 
            260                 265                 270         


Glu Asp Phe Lys Ser Asn Ile Lys Gly Phe Lys Gly Lys Val Val Lys 
        275                 280                 285             


Asp Glu Asn His Asn Ser Leu Lys Tyr Met Ala Thr His Arg Val Tyr 
    290                 295                 300                 


Ser Ile Leu Ala Phe Lys Gly Leu Lys Tyr Arg Ile Lys Thr Asp Thr 
305                 310                 315                 320 


Phe Ser Lys Val Thr Leu Met Met Gln Met Ile Asp Glu Leu Ser Lys 
                325                 330                 335     


Val Pro Asp Cys Val Tyr Gln Asn Leu Ser Glu Thr Lys Gln Lys Asp 
            340                 345                 350         


Phe Ile Glu Asp Trp Asn Glu Tyr Leu Lys Asp Asn Glu Glu Asn Thr 
        355                 360                 365             


Glu Asn Leu Glu Asn Ser Arg Val Val His Pro Leu Ile Arg Lys Arg 
    370                 375                 380                 


Tyr Glu Asp Lys Phe Asn Tyr Phe Ala Ile Arg Phe Leu Asp Glu Phe 
385                 390                 395                 400 


Ala Asn Phe Lys Thr Leu Lys Phe Gln Val Phe Met Gly Tyr Tyr Ile 
                405                 410                 415     


His Asp Gln Arg Thr Lys Thr Ile Gly Thr Thr Asn Ile Thr Thr Glu 
            420                 425                 430         


Arg Thr Val Lys Glu Lys Ile Asn Val Phe Gly Lys Leu Ser Lys Met 
        435                 440                 445             


Asp Asn Leu Lys Lys His Phe Phe Ser Gln Leu Ser Asp Glu Glu Asn 
    450                 455                 460                 


Thr Asp Trp Glu Phe Phe Pro Asn Pro Ser Tyr Asn Phe Leu Thr Gln 
465                 470                 475                 480 


Ala Asp Asn Ser Pro Ala Asn Asn Ile Pro Ile Tyr Leu Glu Leu Lys 
                485                 490                 495     


Asn Gln Gln Ile Ile Lys Glu Lys Asp Asp Ile Lys Ala Glu Val Asn 
            500                 505                 510         


Asn Ser Gln Asn Arg Asn Pro Asn Lys Pro Ser Lys Arg Asp Leu Leu 
        515                 520                 525             


Asn Lys Ile Ser Asn Thr Asn Glu Asp Phe Tyr Gln Gly Asp Pro Thr 
    530                 535                 540                 


Ala Ile Leu Ser Leu Asn Glu Ile Pro Ala Leu Leu His Leu Phe Leu 
545                 550                 555                 560 


Val Gln Pro Asp Asn Lys Thr Gly Gln Gln Ile Glu Asn Ile Ile Arg 
                565                 570                 575     


Ile Lys Ile Glu Lys Gln Phe Asn Ser Ile Lys Asn Pro Ser Lys Asp 
            580                 585                 590         


Asp Lys Gly Val Pro Lys Ser Leu Phe Ala Asp Thr Asn Val Arg Val 
        595                 600                 605             


Asn Ala Ile Lys Leu Lys Lys Asp Leu Gly Glu Glu Leu Asp Met Leu 
    610                 615                 620                 


Asn Lys Lys Gln Ile Val Phe Lys Glu Asn Gln Lys Ala Ser Ser Asn 
625                 630                 635                 640 


Tyr Asp Glu Leu Leu Lys Lys His Gln Phe Thr Pro Lys Asn Lys Arg 
                645                 650                 655     


Pro Ala Leu Arg Lys Tyr Val Phe Tyr Asn Ser Glu Lys Gly Glu Glu 
            660                 665                 670         


Ala Thr Trp Leu Ala Asn Asp Ile Lys Arg Phe Met Pro Lys Gly Phe 
        675                 680                 685             


Lys Thr Lys Trp Lys Gly Tyr Gln His Ser Glu Leu Gln Arg Lys Leu 
    690                 695                 700                 


Ala Phe Tyr Asp Arg His Thr Lys Gln Asp Ile Lys Glu Leu Leu Ser 
705                 710                 715                 720 


Gly Cys Glu Phe Asp His Phe Leu Leu Asp Ile Asn Ala Cys Phe Lys 
                725                 730                 735     


Glu Asp Asp Phe Glu Asp Phe Phe Ser Lys Tyr Leu Lys Asn Arg Ile 
            740                 745                 750         


Glu Thr Leu Asn Ile Ile Leu Lys Gln Leu His Asp Phe Lys Asn Glu 
        755                 760                 765             


Pro Thr Pro Leu Lys Gly Val Phe Lys Asn Cys Leu Lys Phe Leu Lys 
    770                 775                 780                 


Gln Lys Asn Tyr Val Thr Glu Asn Pro Glu Ile Ile Lys Lys Arg Ile 
785                 790                 795                 800 


Leu Ala Lys Pro Ala Phe Leu Pro Arg Gly Ile Phe Asp Glu Arg Pro 
                805                 810                 815     


Thr Met Lys Lys Gly Lys Asn Pro Leu Ile Asp Arg Asp Glu Phe Ala 
            820                 825                 830         


Lys Trp Phe Val Glu Tyr Leu Glu Asn Lys Asp Tyr Gln Lys Phe Tyr 
        835                 840                 845             


Asn Ser Glu Glu Tyr Arg Ile Arg Asp Ala Asp Phe Lys Lys Asn Ala 
    850                 855                 860                 


Val Ile Lys Lys Gln Lys Leu Lys Asp Phe Tyr Thr Leu Gln Met Val 
865                 870                 875                 880 


Asn Tyr Leu Leu Lys Glu Val Phe Gly Lys Asp Glu Met Asn Leu Gln 
                885                 890                 895     


Leu Ser Glu Leu Phe Gln Thr Arg Gln Glu Arg Leu Lys Leu Gln Gly 
            900                 905                 910         


Ile Ala Lys Pro 
        915     


<210>  2770
<211>  1018
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2770

Met Lys Lys Asn Ile Asn Pro Phe Asn Leu Phe Phe Leu Glu Lys Gly 
1               5                   10                  15      


Tyr Ile Gly Ser Ile Ala Gln Lys Ala Glu Asn Asn Phe Ser Thr Asn 
            20                  25                  30          


Cys Lys Ala Leu Asn Gly Ser Gln Ile Ser Asp Lys Glu Asn Lys Ala 
        35                  40                  45              


Thr Ser Arg Ile Tyr Tyr Phe Ala Val Gly His Ala Phe Lys Asn Ile 
    50                  55                  60                  


Asp Thr Lys Ala Ile Phe Ala Tyr Lys Tyr Asp Asp Asp Lys Lys Asn 
65                  70                  75                  80  


Leu Arg Ala Thr Gln Tyr Val His Ile Gln Arg Asn Val Phe Asp Gln 
                85                  90                  95      


Gly Leu Arg Asp Phe Ile Gly Glu Lys Val His Ala Ile Arg Asn Met 
            100                 105                 110         


Cys Ser His Tyr Val His Leu Phe Asn Asp Ile Lys Leu Glu Asp Glu 
        115                 120                 125             


Asp Ser Asp Lys Ala Asn Ile Ile Gln Asp Gln Phe Ile Pro Phe Val 
    130                 135                 140                 


Lys Glu Ala Phe Lys Leu Ala Val Val Gln Ala Tyr Pro Gly Glu Ser 
145                 150                 155                 160 


Asp Met Thr Ile Asp Lys Val Asp Asp Ala Lys Ile Ile Arg Phe Leu 
                165                 170                 175     


Tyr Asp Asn Phe Ile Ser Lys Gly Glu Tyr Asp Asp Leu Glu Glu Lys 
            180                 185                 190         


Lys Gln Phe Phe Lys Leu Ser Ser Asp Lys Ala Leu Glu Lys Val Leu 
        195                 200                 205             


Phe Ile Asp Leu Asp Glu Asp Gln Ser Ile Cys Ile Gly Pro Gly Tyr 
    210                 215                 220                 


Glu Val Phe Thr Ala Thr Lys Gly Arg Tyr Leu Ser Phe Tyr Ala Ser 
225                 230                 235                 240 


Leu Phe Leu Leu Ser Met Phe Leu Tyr Arg Asn Glu Ala Glu Ile Leu 
                245                 250                 255     


Ile Ser Arg Ile Lys Gly Phe Lys Asp Lys Arg Asp Ile Gly Asn Ile 
            260                 265                 270         


Ala Lys Arg Ser Val Phe Thr Phe Phe Ser Lys Lys Val Ser Ser Arg 
        275                 280                 285             


Asp Val Asp Asn Glu Glu Met Pro Leu Val Lys Phe Arg Asp Ile Met 
    290                 295                 300                 


Gln Tyr Leu Asn His Tyr Pro Thr Ala Trp Asn Asp Gln Leu Ser Asp 
305                 310                 315                 320 


Tyr Ser Ser Ser Glu Ser Ser Lys Asn Leu Cys Asn Lys Ile Val Glu 
                325                 330                 335     


Met Asp Ile Lys Arg Leu Phe His Glu Met Phe Glu Thr Glu Asn Glu 
            340                 345                 350         


Glu Ser Leu Arg Phe Leu Thr Tyr Val Lys Leu Thr Gln Tyr Glu Ala 
        355                 360                 365             


Leu Tyr Pro Lys Lys Tyr Val Arg Ala Glu Phe Leu Lys Ala Asp Phe 
    370                 375                 380                 


Thr Ser Arg Glu Thr Glu His Phe Asp Ile Ile Ile Lys Glu Ser Lys 
385                 390                 395                 400 


Glu Leu Lys Gly Cys Arg Lys Lys Leu Gln Asp Leu Leu His Ala Asp 
                405                 410                 415     


Ser Leu Gly Asn Glu Lys Glu Lys Glu Ile Ala Glu Cys Thr Glu Lys 
            420                 425                 430         


Ile Gln Glu Leu Glu Gly Ala Glu Thr Asn Pro Asp Leu Asp Ala Val 
        435                 440                 445             


Arg Lys Gln Ile Asp Asp His Leu Phe Ile Thr Ser Tyr Gly Arg Asn 
    450                 455                 460                 


Gln Asp Arg Phe Met Asp Phe Ala Ala Arg Phe Leu Ala Glu Val Glu 
465                 470                 475                 480 


Tyr Phe Gly Lys Asp Ala Phe Phe Lys Val Tyr Arg Phe Glu Thr Ile 
                485                 490                 495     


Glu Glu Gln Ser Lys Tyr Leu Glu Lys Val Lys Asn Gln Leu Pro Lys 
            500                 505                 510         


Glu Gln Tyr Asp Lys Leu Lys Met His Arg Gly Arg Leu Ala Thr Tyr 
        515                 520                 525             


Met Asn His Asn Gln Ile Ile Asn Tyr Tyr Ser Ser Phe Asp Ile Pro 
    530                 535                 540                 


Phe Val Ile Glu Asn Asn Ser Ile Gln Val Phe Met Pro Ser Ser Lys 
545                 550                 555                 560 


Ile Ile Glu Asp Met Asp Asp Gln Met Leu Lys Lys Ile Phe Lys Gly 
                565                 570                 575     


Lys Gly Thr Phe Tyr Val Ile Gln Arg Pro Leu Ile Ile Tyr Leu Leu 
            580                 585                 590         


Glu Gln Phe Leu Tyr Glu Pro Ser Gly Arg Lys Lys Met Thr Phe Lys 
        595                 600                 605             


Ala Leu Ile Glu Asn Tyr Cys Gly Arg Arg Lys Lys Gly Leu Glu Lys 
    610                 615                 620                 


Tyr Glu Thr Leu Leu Leu Lys Asp Ser Asp Ser Lys Ala Ala Glu Leu 
625                 630                 635                 640 


Gln Asp Gln Arg Ser Glu Met Gly Lys Leu Leu Pro Lys Arg Leu Leu 
                645                 650                 655     


His His Tyr Leu Ser Asp Ser Pro Lys Glu Ser Met Pro Leu Gly Leu 
            660                 665                 670         


Thr Glu Leu Leu Glu Asp Ala Lys Gln Gln Glu Ala Arg Tyr Asn Arg 
        675                 680                 685             


Met Phe Asp Glu Ala Glu Arg Tyr Gly His Leu Gly Asp Phe Leu Lys 
    690                 695                 700                 


Lys Asn Lys Gly Lys Gln Phe Lys Leu Arg Phe Val Arg Lys Ala Trp 
705                 710                 715                 720 


Asn Leu Met Tyr Phe Thr Asp Ile Tyr Trp Val Gln Arg Met Glu Cys 
                725                 730                 735     


Gly Asp Lys His His Lys Gln Phe Asn Ile Thr Arg Asp Glu Phe Asn 
            740                 745                 750         


Asn Phe Ser Gln Trp Met Tyr Ala Phe Asp Glu Ile Pro Glu Tyr Lys 
        755                 760                 765             


Glu Cys Leu Asn Arg Leu Phe Leu Ser Lys Arg Phe Phe Asp Val Lys 
    770                 775                 780                 


Glu Phe Ala Thr Leu Phe Glu Ser Gly Lys Ser Leu Glu Asp Phe Tyr 
785                 790                 795                 800 


Leu Lys Thr Lys Gly Leu Tyr Lys Arg Trp Leu Asp Asn Lys Glu Tyr 
                805                 810                 815     


Leu Asn Ser Asn Asn Lys Pro Lys Ile Glu Lys Asn Thr Trp Asn Asn 
            820                 825                 830         


Tyr Lys Lys Ile Leu Asp Gly Ser Thr Val Cys Ile Asn Leu Ser Leu 
        835                 840                 845             


Phe Ile Lys Ile Leu Glu Asp Lys Asn Leu Leu Glu Lys Asp Ala Asp 
    850                 855                 860                 


Asn His Ile Ile Tyr Lys Ala Gln Glu Asn Met Gln Tyr Leu Ile Ser 
865                 870                 875                 880 


Asp Tyr Tyr Met Asp Leu Ser Phe Asp Arg Val Tyr Lys Asp Arg Leu 
                885                 890                 895     


Gly Asp Asp Glu Ser His Ala Tyr Lys Lys Leu Tyr Asn Lys Leu Arg 
            900                 905                 910         


Thr Asn Arg Leu Glu Asp Ala Leu Leu Tyr Glu Met Ala Leu Tyr Tyr 
        915                 920                 925             


Met Ser Met Val Asn Ile Gly Val Lys Glu Ala Arg Thr His Val Cys 
    930                 935                 940                 


Asp Leu Phe Asn Lys Glu Ile Asp Phe Ser Val Tyr Lys Asp Asp Asp 
945                 950                 955                 960 


Lys Glu Ser Tyr Leu Tyr Lys Val Gln Ile Pro Phe Tyr Lys Ile Asp 
                965                 970                 975     


Ala Phe Asp Gly Leu Ala Val Met Asn Lys Ser Tyr Asp Lys Phe Pro 
            980                 985                 990         


Pro Phe Thr His Gln Leu Tyr Gly  Tyr Leu Thr Glu Asp  Lys Tyr Gln 
        995                 1000                 1005             


Ser Val  Phe Leu Ser Ser Glu  Arg Asn Ala 
    1010                 1015             


<210>  2771
<211>  905
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2771

Met Asn Pro Val Asp Ile Lys Glu Ala Ser Lys Lys Ala Val Tyr Tyr 
1               5                   10                  15      


Ile Asp Gln Tyr Lys Gly Asp Lys Lys Trp Cys Phe Ala Ile Val Leu 
            20                  25                  30          


Asn Arg Ala Tyr Asp Asn Leu Glu Asp Asn Pro Asn Leu Leu Asn Glu 
        35                  40                  45              


Ser Leu Leu Arg Phe Glu Asn Ile Ser Leu Met Ser Trp Phe Asp Phe 
    50                  55                  60                  


Gln Glu Asp Glu Lys Gln Met Arg Asp Ser Val Phe Gln Gly Tyr Glu 
65                  70                  75                  80  


Asn Ile Asn Lys Ala Glu Gln Lys Lys Glu Ile Lys Leu Lys Pro Asp 
                85                  90                  95      


Ile Gln Lys Ala Val Val Lys Arg Leu Glu Asp Leu Arg Asn Tyr Phe 
            100                 105                 110         


Ser His Arg Leu His Thr Asp Asp Cys Leu Thr Phe Leu Lys Glu Asp 
        115                 120                 125             


Pro Ile Arg Phe Ile Leu Glu Lys Ala Tyr Glu Lys Ala Lys Leu Val 
    130                 135                 140                 


His Leu Gly Arg Glu Thr Gln Glu Ser Lys Asp Phe Ser Val Pro Leu 
145                 150                 155                 160 


Phe Glu Asp Asp Lys Ile Thr Thr Ala Gly Val Ile Leu Phe Ala Ser 
                165                 170                 175     


Phe Phe Val Glu Met Arg Ile Leu Ile Arg Val Leu Gly Leu Lys Asp 
            180                 185                 190         


Val Arg Gly Phe Thr Leu Thr Glu Gly Lys Phe Asn Leu Thr Arg Lys 
        195                 200                 205             


Ala Ile Cys His Tyr Ala Leu Pro Asp Ser Tyr Ser Ile Lys Thr Pro 
    210                 215                 220                 


Arg Asp Thr Lys Leu Phe Arg Asp Ile Leu Gly Tyr Leu Ser Arg Met 
225                 230                 235                 240 


Pro Ser Glu Ser Tyr Asp His Tyr Phe Pro Glu Ala Lys Lys Lys Ala 
                245                 250                 255     


Glu Glu Gly Glu Lys Asp Lys Glu Gly Glu Gly Lys Asp Lys Glu Asn 
            260                 265                 270         


Lys Glu Pro Gln Trp Ser Lys Arg Asn Thr Asp Lys Phe Met Val Phe 
        275                 280                 285             


Ala Met Arg Tyr Leu Glu Asp Phe Gln Pro Asp Val Phe Arg Ile Cys 
    290                 295                 300                 


Phe Ala Arg Gln Asp Ile Gln Gln Pro Gln Arg Glu Lys Asp Gln Glu 
305                 310                 315                 320 


Arg Lys Pro His Lys Gln Lys Gly Lys Arg Lys Leu Gln Phe Pro Glu 
                325                 330                 335     


Asn Leu Gln Glu Ala Arg Asp Asn Pro Ala Val Arg Tyr Phe Ile Arg 
            340                 345                 350         


Gln Asn Asn Ile Asp Ile Gln Ile Gln Lys Asn Asn Gln Lys Ile His 
        355                 360                 365             


Cys Arg Met Gly Leu Asn Glu Leu Lys Tyr Leu Ile Leu Leu Cys Leu 
    370                 375                 380                 


Lys Gly Gln Gly Gly Glu Ala Ile Glu Ala Ile Tyr Asn Glu Ala Gly 
385                 390                 395                 400 


Gln Val Gly Asn Lys Leu Pro His Leu Ala Lys Met Arg Lys Glu Gly 
                405                 410                 415     


Phe Gln Asp Tyr Gln Lys Trp Met Pro Gly Phe Val Leu Asn His His 
            420                 425                 430         


Gly Leu Met Pro Glu Gly Pro Asn Arg Lys Glu Pro Val Ala Ala Arg 
        435                 440                 445             


Val Gly Tyr Ile Arg Gln Lys Trp Glu Arg Lys Arg Asp Gly Ser Lys 
    450                 455                 460                 


Glu Ala Arg Leu Asp Ser Lys Ala Arg Asp Ile Leu Gln Tyr Ile Asn 
465                 470                 475                 480 


Glu Cys Gly Gln Glu Tyr Ala Leu Gln Gln Asp Arg Glu Arg Lys Gly 
                485                 490                 495     


Thr Leu Asn Ile Asp Lys Tyr Arg Lys Ile His Asp Phe Leu Val Asn 
            500                 505                 510         


Lys Asn Ile Glu Ala Phe Arg Gln Glu Leu Asp Gly Leu Lys Val Asp 
        515                 520                 525             


Glu Lys Val Arg Glu Asp Leu Lys Lys Arg Gln Thr Val Asn Asp Leu 
    530                 535                 540                 


His Gln Arg Val Cys Asn Leu Met Ile Arg Lys Leu Glu Asp Leu Gln 
545                 550                 555                 560 


Gln Ser Gly Asp Leu Glu Gln Leu Lys Cys Tyr Ile Gly Leu Ala Pro 
                565                 570                 575     


Ala Trp Glu Tyr Arg Asp Glu Asp Gln Thr Gly Lys Glu Gln Lys Glu 
            580                 585                 590         


Gln Arg Phe Glu Asn Lys Val Lys Asn Leu Lys Pro Met Leu Tyr Arg 
        595                 600                 605             


Gly Phe Leu Arg Glu Arg Phe Phe Ala Glu Tyr Arg Ser Lys Glu Asn 
    610                 615                 620                 


Lys Arg Asn Phe Ala Asp Leu Val Glu Asp Val Arg Gln Lys Lys Gly 
625                 630                 635                 640 


Glu Gly Asp Val Pro Val Asp Leu Ile Tyr Tyr Gln Ile Glu Gly Asp 
                645                 650                 655     


Thr Gln Glu Ile Gln Val Ala Asn Lys Lys Leu Thr Glu Thr Leu Ala 
            660                 665                 670         


Arg Asp Arg Leu Cys Leu Leu Ile Gly Arg Glu Tyr Leu Glu Gln Leu 
        675                 680                 685             


Asn Arg Thr Leu Ser Gln Asn Ala Ile Glu Glu Arg His Gly Pro Lys 
    690                 695                 700                 


Arg Lys Tyr Phe Ile Lys Thr Glu Trp Ser Lys Glu Pro Val Gln Met 
705                 710                 715                 720 


Gly Asp Gly Lys Glu Arg Met Arg Asp Val Ile Ile Cys Arg Ile Arg 
                725                 730                 735     


Glu Asn Pro Glu Asp Glu Asn Pro Leu Cys Ser Ile Arg Phe Ala Val 
            740                 745                 750         


Lys His Trp Thr Lys Leu Tyr Val Met Asp Asp Pro Phe Phe Leu Ser 
        755                 760                 765             


Asp Val His Ser Tyr Phe Leu Ser Lys Ser Asn Glu Ile Asp Tyr His 
    770                 775                 780                 


Thr Leu Asn Gln Lys Gly Ile Cys Gln Tyr Thr Asn Leu Gln Ala Asp 
785                 790                 795                 800 


Cys Met Val Asn Ile Leu Lys Leu Glu Lys Lys Val Phe Glu Arg Val 
                805                 810                 815     


Thr Lys Arg Asp Ile Asp Lys Glu Lys Asp Ile Lys Lys Leu Ile Asn 
            820                 825                 830         


Glu Ile Asn Asn Lys Leu Gln His Leu Pro Ala Lys Lys Glu Asp Asn 
        835                 840                 845             


Arg Val Pro Phe Leu Leu Val Cys Glu Ala Ala Leu Glu Lys Gly Ile 
    850                 855                 860                 


Leu Lys Glu Lys Ser Glu Ile Asp Val Val Ser Met Val Arg Asn Ser 
865                 870                 875                 880 


Ala Phe His Tyr Gln Leu Tyr Phe Ser Lys Ser Glu Lys Glu Thr Phe 
                885                 890                 895     


Asp Arg Ile Met Arg Arg Glu Gly Ile 
            900                 905 


<210>  2772
<211>  900
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2772

Met Gln Thr Ala Thr Gln Glu Gln Lys Gln Lys Gln Ser Ile Tyr Ser 
1               5                   10                  15      


Ile Leu Asn Tyr Gln Gly Gln Arg Lys Trp Cys Phe Ala Ile Val Leu 
            20                  25                  30          


Asn Arg Ala Leu Asp Asn Ile Asn Pro Lys Arg Glu Thr Glu Thr Gly 
        35                  40                  45              


Lys Tyr Lys Asn Lys Glu Leu Phe Tyr Lys Ser Leu Leu Arg Phe Glu 
    50                  55                  60                  


Gly Ile Lys Lys Gln Pro Trp Phe Asp Glu Thr Lys Ala Glu Lys Glu 
65                  70                  75                  80  


Asn Val Thr Ala Lys Glu Ile Ile Asp Ser Lys Asp Lys Ala Ala Glu 
                85                  90                  95      


Leu Leu Leu Asn Leu Arg Asn Tyr Phe Ser His Asn Tyr His Thr Glu 
            100                 105                 110         


Lys Cys Leu Tyr Phe Gly Thr Glu Ser Gln His Lys Gln Ile Arg Leu 
        115                 120                 125             


Ile Met Glu Ala Ala Tyr Glu Arg Ala Lys Ala Glu Leu Thr Gly Arg 
    130                 135                 140                 


Arg Thr Gly Gln Glu Ile Ser Ala Glu Ala Glu Lys Asp Lys Asp Gly 
145                 150                 155                 160 


Asn Ile Lys Lys Tyr Lys Leu Ser Asp Val Pro Trp Pro Pro Leu Phe 
                165                 170                 175     


Asp Glu Lys Asp Ile Ile Thr Thr Ala Gly Val Val Phe Phe Ala Ser 
            180                 185                 190         


Phe Phe Thr Glu Ala Gly Gln Ile Phe Arg Leu Met Asn Trp Ile Asn 
        195                 200                 205             


Gly Leu Lys Arg Asn Asp Asp Lys Phe Asn Ile Thr Arg Arg Ala Leu 
    210                 215                 220                 


Ser Phe Tyr Ser Leu Pro Asp Ser Tyr Ala Glu Ala Ile Ala Glu Tyr 
225                 230                 235                 240 


Glu Val Glu Glu Asp Gly Ala Ser Arg Thr Ile Arg Tyr Lys Ala Lys 
                245                 250                 255     


Ile Phe Lys Asp Ile Leu Asn Tyr Leu Arg Arg Ile Pro Ser Glu Thr 
            260                 265                 270         


Tyr Lys Leu Tyr His Ser Gly Glu Glu Asn Lys Ile Ser Gly Lys Lys 
        275                 280                 285             


Glu Glu Lys Gly Glu Asp Glu Asn Thr Pro Val Glu Arg Lys Thr Asp 
    290                 295                 300                 


Lys Phe Ala Glu Phe Ala Met Arg Tyr Leu Glu Asp Phe Glu Gly Val 
305                 310                 315                 320 


Arg Phe Ala Arg Tyr Arg Ile Asn Thr Lys Thr Arg Glu Asn Glu Val 
                325                 330                 335     


Phe Phe Asp Glu Asp Glu Leu Lys Lys Leu Ile Asp Lys Lys Gly Val 
            340                 345                 350         


Pro Glu Gln Glu Lys Asp Lys Lys Phe Glu Asp Tyr Arg Tyr Tyr Tyr 
        355                 360                 365             


Val Lys Asn Asn Ala Ile Leu Lys Thr Glu Lys Gly Ser Ile Arg Ile 
    370                 375                 380                 


Gly Ile Asn Glu Leu Lys Tyr Phe Val Leu Leu Ser Leu Asp Lys Met 
385                 390                 395                 400 


Gly Gln Gln Ala Lys Glu Lys Ile Asn Ser Phe Leu Ser Lys Phe Thr 
                405                 410                 415     


Gly Asp Asn Leu Gly Asn Arg Glu Phe Ile Lys Ala Asn Ile Glu Glu 
            420                 425                 430         


Leu Pro Pro Phe Ile Leu Lys Lys Phe Asp Pro Leu Ala Glu Asp Lys 
        435                 440                 445             


Glu Lys Arg Ile Glu Lys Arg Val Asp Tyr Leu Ile Arg Lys Trp Lys 
    450                 455                 460                 


Arg Lys Lys Glu Asp Tyr Glu Lys Met Arg Ile Asn Asp Lys Val Gly 
465                 470                 475                 480 


Gly Ile Leu Arg Tyr Val Asn Glu Asn Leu Lys Pro Gly Lys Lys Leu 
                485                 490                 495     


Asn Ala Glu Gly Tyr Lys Tyr Leu Gln Lys Leu Leu Thr Met Glu Arg 
            500                 505                 510         


Phe Ser Glu Phe Glu Lys Glu Ile Asn Lys Phe Glu Asp Glu Arg Glu 
        515                 520                 525             


Ser Arg Leu Lys Arg Gly Ala Leu Ser Glu Ile Glu Arg Leu Lys Ser 
    530                 535                 540                 


Ile Asp Lys Met Phe Leu Lys Val Cys Ser Ile Val Leu Lys Lys Leu 
545                 550                 555                 560 


Glu Ser Leu Glu Gly Asp Glu Leu Ala Gly Tyr Ile Gly Leu Lys Lys 
                565                 570                 575     


Gln Pro Leu Thr Asp Glu Lys Ala Ala Glu Asn Gln Glu Tyr Asp Asn 
            580                 585                 590         


Val Leu Gln Arg Tyr Ile Glu Thr Lys Ile Ala Leu Pro Lys Gly Thr 
        595                 600                 605             


Leu Arg Asp Leu Tyr Leu Lys Thr Gly Gly Lys Asn Asn Phe Ser Asp 
    610                 615                 620                 


Ala Val Glu Asp Val Leu Glu Lys Lys Lys Leu Asp Phe Asp Ile Glu 
625                 630                 635                 640 


Leu Asp Lys Lys Tyr Tyr Asp Tyr Glu Ile Asp Lys Arg Lys Glu Ala 
                645                 650                 655     


Pro Lys Asp Arg Glu Gly Leu Lys Thr Ala Arg Lys Leu Arg Glu Thr 
            660                 665                 670         


Met Ala Lys Asp Arg Leu Cys Leu Leu Thr Gly Met Lys Phe Tyr Glu 
        675                 680                 685             


Asn Ile Arg Glu Asp Leu Asn Ile Arg Trp Glu Arg Arg Val Gly Lys 
    690                 695                 700                 


Asn Val Ile Tyr Ala Asp Ile Tyr Lys Lys Gly Asp Lys Thr Lys Lys 
705                 710                 715                 720 


Leu Phe Thr Leu Lys Phe Ser Glu Lys Asp Tyr Val Lys Met Tyr Val 
                725                 730                 735     


Ile Asp Asn Thr Asp Phe Leu Arg Gln Val Trp Glu Lys Phe Val Lys 
            740                 745                 750         


Gly Lys Glu Gly Gln Glu Val Asn Tyr His Glu Phe Tyr Gln Lys Gly 
        755                 760                 765             


Ile Gln Lys Gly Leu Gly Asp Phe Gln Arg Asp Val Ala Leu Lys Val 
    770                 775                 780                 


Leu Lys Phe Glu Glu Thr Val Val Glu Lys Asn Ala Gly Thr Gly Leu 
785                 790                 795                 800 


Pro Val Ser Gly Ile Asn Asn Lys Leu Ser Gly Ile Ile Lys Asn Arg 
                805                 810                 815     


Gly Arg Glu Met Lys Ser Asp Phe Asn Lys His Arg Asp Val Phe Val 
            820                 825                 830         


Ser Asn Asp Thr Ile Cys Lys Ala Phe Phe Asp Asp Ala Asp Asp Ile 
        835                 840                 845             


Glu Arg Val Lys Lys Ile Arg Asn Ser Ala Phe His Tyr Asn Ala Asp 
    850                 855                 860                 


Phe Glu Asp Glu Asp Tyr Thr Gly Phe Asn Lys Ile Met Asp Arg Glu 
865                 870                 875                 880 


Gly Ile Lys Ile Lys Glu Ile Asp Gly Lys Lys Gln Glu Gly Lys Gln 
                885                 890                 895     


Arg Lys Arg Phe 
            900 


<210>  2773
<211>  1137
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2773

Met Glu Lys Phe Arg Arg Gln Asn Arg Asn Ser Ile Ile Lys Ile Ile 
1               5                   10                  15      


Ile Ser Asn Tyr Asp Thr Lys Gly Ile Lys Glu Leu Lys Val Arg Tyr 
            20                  25                  30          


Arg Lys Gln Ala Gln Leu Asp Thr Phe Ile Ile Lys Thr Glu Ile Val 
        35                  40                  45              


Asn Asn Asp Ile Phe Ile Lys Ser Ile Ile Glu Lys Ala Arg Glu Lys 
    50                  55                  60                  


Tyr Arg Tyr Ser Phe Leu Phe Asp Gly Glu Glu Lys Tyr His Phe Lys 
65                  70                  75                  80  


Asn Lys Ser Ser Val Glu Ile Val Lys Lys Asp Ile Phe Ser Gln Thr 
                85                  90                  95      


Pro Asp Asn Met Ile Arg Asn Tyr Lys Ile Thr Leu Lys Ile Ser Glu 
            100                 105                 110         


Lys Asn Pro Arg Val Val Glu Ala Glu Ile Glu Asp Leu Met Asn Ser 
        115                 120                 125             


Thr Ile Leu Lys Asp Gly Arg Arg Ser Ala Arg Arg Glu Lys Ser Met 
    130                 135                 140                 


Thr Glu Arg Lys Leu Ile Glu Glu Lys Val Ala Glu Asn Tyr Ser Leu 
145                 150                 155                 160 


Leu Ala Asn Cys Pro Met Glu Glu Val Asp Ser Ile Lys Ile Tyr Lys 
                165                 170                 175     


Ile Lys Arg Phe Leu Thr Tyr Arg Ser Asn Met Leu Leu Tyr Phe Ala 
            180                 185                 190         


Ser Ile Asn Ser Phe Leu Cys Glu Gly Ile Lys Gly Lys Asp Asn Glu 
        195                 200                 205             


Thr Glu Glu Ile Trp His Leu Lys Asp Asn Asp Val Arg Lys Glu Lys 
    210                 215                 220                 


Val Lys Glu Asn Phe Lys Asn Lys Leu Ile Gln Ser Thr Glu Asn Tyr 
225                 230                 235                 240 


Asn Ser Ser Leu Lys Asn Gln Ile Glu Glu Lys Glu Lys Leu Leu Arg 
                245                 250                 255     


Lys Glu Ser Lys Lys Gly Ala Phe Tyr Arg Thr Ile Ile Lys Lys Leu 
            260                 265                 270         


Gln Gln Glu Arg Ile Lys Glu Leu Ser Glu Lys Ser Leu Thr Glu Asp 
        275                 280                 285             


Cys Glu Lys Ile Ile Lys Leu Tyr Ser Glu Leu Arg His Pro Leu Met 
    290                 295                 300                 


His Tyr Asp Tyr Gln Tyr Phe Glu Asn Leu Phe Glu Asn Lys Glu Asn 
305                 310                 315                 320 


Ser Glu Leu Thr Lys Asn Leu Asn Leu Asp Ile Phe Lys Ser Leu Pro 
                325                 330                 335     


Leu Val Arg Lys Met Lys Leu Asn Asn Lys Val Asn Tyr Leu Glu Asp 
            340                 345                 350         


Asn Asp Thr Leu Phe Val Leu Gln Lys Thr Lys Lys Ala Lys Thr Leu 
        355                 360                 365             


Tyr Gln Ile Tyr Asp Ala Leu Cys Glu Gln Lys Asn Gly Phe Asn Lys 
    370                 375                 380                 


Phe Ile Asn Asp Phe Phe Val Ser Asp Gly Glu Glu Asn Thr Val Phe 
385                 390                 395                 400 


Lys Gln Ile Ile Asn Glu Lys Phe Gln Ser Glu Met Glu Phe Leu Glu 
                405                 410                 415     


Lys Arg Ile Ser Glu Ser Glu Lys Lys Asn Glu Lys Leu Lys Lys Lys 
            420                 425                 430         


Phe Asp Ser Met Lys Ala His Phe His Asn Ile Asn Ser Glu Asp Thr 
        435                 440                 445             


Lys Glu Ala Tyr Phe Trp Asp Ile His Ser Ser Ser Asn Tyr Lys Thr 
    450                 455                 460                 


Lys Tyr Asn Glu Arg Lys Asn Leu Val Asn Glu Tyr Thr Glu Leu Leu 
465                 470                 475                 480 


Gly Ser Ser Lys Glu Lys Lys Leu Leu Arg Glu Glu Ile Thr Gln Ile 
                485                 490                 495     


Asn Arg Lys Leu Leu Lys Leu Lys Gln Glu Met Glu Glu Ile Thr Lys 
            500                 505                 510         


Lys Asn Ser Leu Phe Arg Leu Glu Tyr Lys Met Lys Ile Ala Phe Gly 
        515                 520                 525             


Phe Leu Phe Cys Glu Phe Asp Gly Asn Ile Ser Lys Phe Lys Asp Glu 
    530                 535                 540                 


Phe Asp Ala Ser Asn Gln Glu Lys Ile Ile Gln Tyr His Lys Asn Gly 
545                 550                 555                 560 


Glu Lys Tyr Leu Thr Tyr Phe Leu Lys Glu Glu Glu Lys Glu Lys Phe 
                565                 570                 575     


Asn Leu Glu Lys Met Gln Lys Ile Ile Gln Lys Thr Glu Glu Glu Asp 
            580                 585                 590         


Trp Leu Leu Pro Glu Thr Lys Asn Asn Leu Phe Lys Phe Tyr Leu Leu 
        595                 600                 605             


Thr Tyr Leu Leu Leu Pro Tyr Glu Leu Lys Gly Asp Phe Leu Gly Phe 
    610                 615                 620                 


Val Lys Lys His Tyr Tyr Asp Ile Lys Asn Val Asp Phe Met Asp Glu 
625                 630                 635                 640 


Asn Gln Asn Asn Ile Gln Val Ser Gln Thr Val Glu Lys Gln Glu Asp 
                645                 650                 655     


Tyr Phe Tyr His Lys Ile Arg Leu Phe Glu Lys Asn Thr Lys Lys Tyr 
            660                 665                 670         


Glu Ile Val Lys Tyr Ser Ile Val Pro Asn Glu Lys Leu Lys Gln Tyr 
        675                 680                 685             


Phe Glu Asp Leu Gly Ile Asp Ile Lys Tyr Leu Thr Gly Ser Val Glu 
    690                 695                 700                 


Ser Gly Glu Lys Trp Leu Gly Glu Asn Leu Gly Ile Asp Ile Lys Tyr 
705                 710                 715                 720 


Leu Thr Val Glu Gln Lys Ser Glu Val Ser Glu Glu Lys Asn Lys Lys 
                725                 730                 735     


Val Ser Leu Lys Asn Asn Gly Met Phe Asn Lys Thr Ile Leu Leu Phe 
            740                 745                 750         


Val Phe Lys Tyr Tyr Gln Ile Ala Phe Lys Leu Phe Asn Asp Ile Glu 
        755                 760                 765             


Leu Tyr Ser Leu Phe Phe Leu Arg Glu Lys Ser Glu Lys Pro Phe Glu 
    770                 775                 780                 


Val Phe Leu Glu Glu Leu Lys Asp Lys Met Ile Gly Lys Gln Leu Asn 
785                 790                 795                 800 


Phe Gly Gln Leu Leu Tyr Val Val Tyr Glu Val Leu Val Lys Asn Lys 
                805                 810                 815     


Asp Leu Asp Lys Ile Leu Ser Lys Lys Ile Asp Tyr Arg Lys Asp Lys 
            820                 825                 830         


Ser Phe Ser Pro Glu Ile Ala Tyr Leu Arg Asn Phe Leu Ser His Leu 
        835                 840                 845             


Asn Tyr Ser Lys Phe Leu Asp Asn Phe Met Lys Ile Asn Thr Asn Lys 
    850                 855                 860                 


Ser Asp Glu Asn Lys Glu Val Leu Ile Pro Ser Ile Lys Ile Gln Lys 
865                 870                 875                 880 


Met Ile Gln Phe Ile Glu Lys Cys Asn Leu Gln Asn Gln Ile Asp Phe 
                885                 890                 895     


Asp Phe Asn Phe Val Asn Asp Phe Tyr Met Arg Lys Glu Lys Met Phe 
            900                 905                 910         


Phe Ile Gln Leu Lys Gln Ile Phe Pro Asp Ile Asn Ser Thr Glu Lys 
        915                 920                 925             


Gln Lys Lys Ser Glu Lys Glu Glu Ile Leu Arg Lys Arg Tyr His Leu 
    930                 935                 940                 


Ile Asn Lys Lys Asn Glu Gln Ile Lys Asp Glu His Glu Ala Gln Ser 
945                 950                 955                 960 


Gln Leu Tyr Glu Lys Ile Leu Ser Leu Gln Lys Ile Phe Ser Cys Asp 
                965                 970                 975     


Lys Asn Asn Phe Tyr Arg Arg Leu Lys Glu Glu Lys Leu Leu Phe Leu 
            980                 985                 990         


Glu Lys Gln Gly Lys Lys Lys Leu  Ser Met Glu Glu Asn  Lys Asp Lys 
        995                 1000                 1005             


Ile Ala  Gly Asp Ile Ser Asp  Leu Leu Gly Ile Leu  Lys Lys Glu 
    1010                 1015                 1020             


Ile Thr  Arg Asp Ile Lys Asp  Lys Leu Thr Glu Lys  Phe Arg Tyr 
    1025                 1030                 1035             


Cys Glu  Glu Lys Leu Leu Asn  Ile Ser Phe Tyr Asn  His Gln Asp 
    1040                 1045                 1050             


Lys Lys  Lys Glu Glu Gly Ile  Arg Val Phe Leu Ile  Arg Asp Lys 
    1055                 1060                 1065             


Asn Ser  Asp Asn Phe Lys Phe  Glu Ser Ile Leu Asp  Asp Gly Ser 
    1070                 1075                 1080             


Asn Lys  Ile Phe Ile Ser Lys  Asn Gly Lys Glu Ile  Thr Ile Gln 
    1085                 1090                 1095             


Cys Cys  Asp Lys Val Leu Glu  Thr Leu Met Ile Glu  Lys Asn Thr 
    1100                 1105                 1110             


Leu Lys  Ile Ser Ser Asn Gly  Lys Ile Ile Ser Leu  Ile Pro His 
    1115                 1120                 1125             


Tyr Ser  Tyr Ser Ile Asp Val  Lys Tyr 
    1130                 1135         


<210>  2774
<211>  1035
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2774

Met Thr Asn Asn Lys Lys Pro Ala Asn Lys Asn Ser Ile Ile Arg Val 
1               5                   10                  15      


Ile Ile Ser Asn Phe Asp Glu Asn Ser Ile Lys Glu Ile Lys Val Leu 
            20                  25                  30          


Tyr Thr Lys Gln Gly Gly Val Asp Thr Ile His Ile Lys Lys Met Ser 
        35                  40                  45              


Met Cys Glu Glu Asp Lys Ser Leu Tyr Phe Glu Glu Val Glu Cys Asn 
    50                  55                  60                  


Ser Gln Phe Gly Asn Ile Asp Ile Lys Ile Glu Lys Asp Asn Arg Ser 
65                  70                  75                  80  


Val Ile Val Glu Lys Tyr Asp Lys Tyr Thr Gly Leu Ile Ile Arg Lys 
                85                  90                  95      


Tyr Lys Ile Phe Gly Thr Tyr Val Ile Thr Asn Lys Asn Ile Lys Leu 
            100                 105                 110         


Val Lys Val Tyr Val Gln Asp Ile Leu Asn Glu Lys Ser Thr Asn Lys 
        115                 120                 125             


Arg Arg Ile Glu Ser Tyr Thr Glu Arg Leu Leu Ile Asp Pro Ala Val 
    130                 135                 140                 


Ile Asn Asp Tyr Lys Lys Ile Met Glu Asn Asn Gln Asp Ile Asp Ser 
145                 150                 155                 160 


Lys Asn Ile Tyr Lys Leu Asn Arg Phe Ile Asn Tyr Arg Ser Asn Met 
                165                 170                 175     


Met Leu Tyr Phe Thr Phe Val Tyr Arg Phe Leu Gly Met Glu Leu Gly 
            180                 185                 190         


Thr Asn Gly Glu Val Tyr Lys Leu Asp Gln Glu Cys Asn Leu Glu Lys 
        195                 200                 205             


Gln Lys Lys Val Val Asp Tyr Val Ala Ser Asn Ile Glu Lys Phe Val 
    210                 215                 220                 


Glu Asn His Asn Asn Tyr Ala Gln Lys Arg Asn Glu Glu Thr Glu Glu 
225                 230                 235                 240 


Lys Lys Leu His Arg Asp Lys Glu Ile Leu Ile Glu Ile Asp Lys Lys 
                245                 250                 255     


Leu Leu Glu Lys Asp Ile Lys Asn Ile Ile Thr Ile Val Ala Ser Val 
            260                 265                 270         


Arg His Lys Leu Ala His Tyr Asn Tyr Thr Phe Phe Gln Asp Leu Leu 
        275                 280                 285             


Glu Gly Lys Glu Ile Val Leu Glu Lys Gln Lys Pro Leu Asn Glu Leu 
    290                 295                 300                 


Leu Asp Leu Asn Ile Phe Lys Glu Ile Gly Lys Ile Lys Asn Leu Lys 
305                 310                 315                 320 


Glu Glu Lys Ala Thr Thr Tyr Leu Glu Asp Asp Thr Lys Val Tyr Val 
                325                 330                 335     


Leu Gly Lys His Lys Lys Ala Lys Lys Leu Tyr Asn Tyr Tyr Asp Lys 
            340                 345                 350         


Leu Cys Thr Arg Lys Asp Gly Phe Asn Asn Phe Ile Asn Ser Phe Phe 
        355                 360                 365             


Ser Val Asp Gly Asn Glu Asn Pro Asp Phe Lys Lys His Ile Asn Glu 
    370                 375                 380                 


His Phe Glu Lys Arg Ile Asp Glu Leu Asn Tyr Gln Val Asn Asn Thr 
385                 390                 395                 400 


Lys Lys Val Arg Glu Asp Ile Lys Arg Glu Leu Val Glu Met Gln Glu 
                405                 410                 415     


Ile Lys Lys Leu Ile Gly Glu Ala Tyr Ile Trp Asp Ile His Gln Cys 
            420                 425                 430         


Lys Glu Tyr Lys Arg Ile Tyr Asn Lys Arg Lys Asn Leu Val Glu Glu 
        435                 440                 445             


Val Ser Gln Leu Ser Arg Lys Ala Asn Arg Asp Lys Val Asp Lys Asp 
    450                 455                 460                 


Lys Ile Ser Lys Leu Asn Asn Glu Ile Leu Lys Met Asn Thr Gln Met 
465                 470                 475                 480 


Glu Lys Tyr Thr Lys Leu Asn Ser Lys Phe Arg Leu Gln Tyr Lys Leu 
                485                 490                 495     


Gln Met Ala Tyr Gly Phe Leu Tyr Glu Glu Tyr Gly Phe Asp Leu Lys 
            500                 505                 510         


Arg Phe Gly Asp Arg Phe Asn Ser Ser Ile Leu Asp Glu Leu Lys Pro 
        515                 520                 525             


Tyr Lys Glu Asn Gly Leu Lys Tyr Leu Lys Thr Lys Val Thr Ser Asn 
    530                 535                 540                 


Asp Asn Ile Gly Phe Ser Leu Gly Glu Phe Glu Lys Lys Ile Asn Ala 
545                 550                 555                 560 


Met Lys Ala Met Asp Asn Gly Leu Phe Asn Pro Thr His Ser Asn Asn 
                565                 570                 575     


Leu Phe Lys Trp Tyr Val Leu Met Tyr Ile Leu Leu Pro Thr Glu Ile 
            580                 585                 590         


Arg Gly Asp Phe Leu Gly Phe Val Lys Asn Gln Tyr Tyr Glu Leu Lys 
        595                 600                 605             


His Val Asp Tyr Ile Glu Asp Gln Val Ile Glu Lys Asp Leu Phe Phe 
    610                 615                 620                 


His Arg Met Arg Leu Phe Glu Lys Asn Thr Lys Lys Leu Ser Phe Ile 
625                 630                 635                 640 


Ser Tyr Gly Ile Asp Ser Leu Phe Asp Ile Lys Glu Tyr Phe Asn Tyr 
                645                 650                 655     


Leu Leu Pro Gln Leu Asn Pro Met Glu Met Asp Asp His Phe Val Asn 
            660                 665                 670         


Asn Phe Thr Arg Ser Met Val Leu Pro Met Leu Lys Tyr Tyr Gln Asn 
        675                 680                 685             


Ile Phe Lys Leu Leu Asn Asp Leu Glu Val Ala Ser Leu Ile Lys Tyr 
    690                 695                 700                 


Ser Asn Val Asn Asn Ile His Leu Leu Ser Glu Ala Ile Ala Asn Glu 
705                 710                 715                 720 


Lys Leu Lys Lys Asn Gly Asn Tyr Asn Phe Asn Thr Met Leu Gln Glu 
                725                 730                 735     


Thr Tyr Cys Ile Asp Ala Lys Cys Gly Trp Glu Leu Ser Arg Leu Arg 
            740                 745                 750         


Asn Glu Ile Ala His Leu Asn Ile Asp Arg Leu Phe Ile Glu Ile Pro 
        755                 760                 765             


Lys Asn Asp Glu Leu Asp Arg Asp Ile Asp Lys Leu Ile Asp Phe Leu 
    770                 775                 780                 


Lys Lys Pro Glu Val Asn Asn Asn Gly Met Ala Lys Thr Ile Ile Asn 
785                 790                 795                 800 


Asp Phe Tyr Met Arg His Glu Gln Phe Met His Lys Leu Asn Val Gln 
                805                 810                 815     


Ile Asn Asp Ser Thr Ser Lys Gln Glu Leu Glu Asp Lys Tyr Lys Ala 
            820                 825                 830         


Gln Lys Lys Leu Leu Asn Arg Phe Gln Met Asn Pro Glu Ala Ala Thr 
        835                 840                 845             


Ile Leu Lys Lys Tyr Glu Glu Leu Lys Ala Ile Glu Asn Ile Asn Gln 
    850                 855                 860                 


Ile Asp Leu Asp Leu Trp Gly Lys Ile Gly Asp Ile Glu Ile Ile Asp 
865                 870                 875                 880 


His Lys Lys His Lys Lys Ile Ser Asp Leu Lys Pro Leu Glu Arg Asn 
                885                 890                 895     


Leu Lys Gly Asp Leu Ile Ile Asp Lys Ile Asn Glu Met Ala Glu Leu 
            900                 905                 910         


Leu Phe Gly Ile Tyr Lys Arg Tyr Met Val Arg Asp Ile Lys Lys Ile 
        915                 920                 925             


Leu His Lys Gln Leu Thr Lys Asn Glu Ser Arg Tyr Ile Asn Leu Leu 
    930                 935                 940                 


Ile Tyr Asp Lys Met Asn Ser Glu Glu Ala Leu Arg Asn Lys Glu Ile 
945                 950                 955                 960 


Ile Tyr Thr Val His Met Lys Lys Asp Lys Glu Lys Trp Lys Ile Glu 
                965                 970                 975     


Asn Asp Glu Val Val Asn Glu Val Met Gln Leu His Asn Ile Glu Ile 
            980                 985                 990         


Ile Ser Asn Glu Lys Gly Leu Leu  Arg Cys Ile Pro Lys  Asn Glu Ala 
        995                 1000                 1005             


Ser Ile  Met Glu Leu Asp Ile  Asn Arg Ser Tyr Ile  Gln Lys Met 
    1010                 1015                 1020             


Lys Ile  Ile Val Ser Asn Asn  Ser Val Asp His Glu  
    1025                 1030                 1035 


<210>  2775
<211>  1117
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2775

Met Glu Asn Lys Asn Lys Thr Lys Pro Asn Arg Gly Ser Ile Val Arg 
1               5                   10                  15      


Ile Ile Ile Ser Asn Tyr Asp Thr Lys Gly Ile Lys Glu Ile Lys Val 
            20                  25                  30          


Arg Tyr Arg Lys Gln Ala Gln Leu Asp Thr Phe Ile Leu Gln Thr Thr 
        35                  40                  45              


Leu Asp Lys Gly Asn Asn Ser Ile Leu Ile Ser Glu Phe Arg Val Lys 
    50                  55                  60                  


Ala Arg Glu Lys Asn Arg Tyr Ser Phe Thr Tyr Asp Gly Lys Glu Lys 
65                  70                  75                  80  


Phe Ser Ala Pro Ser Asn Ser Val Val Ile Thr Lys Ile Asp Asn Ala 
                85                  90                  95      


Ala Pro Glu Lys Phe Lys Glu Ile Arg Lys Tyr Lys Ile Thr Leu Glu 
            100                 105                 110         


Ile Asp Glu Lys Cys Lys Thr Gly Asn Met Ile Thr Ala Ala Ile Glu 
        115                 120                 125             


Asp Leu Leu Glu Asp Asp Ile Ala Arg Glu Gly Ile Arg Asn Pro Arg 
    130                 135                 140                 


Arg Lys Ala Ser Lys Thr Glu Arg Lys Leu Ile Ala Glu Ser Ile Cys 
145                 150                 155                 160 


His Asn Tyr Ala Gln Ile Ala Gln Cys Pro Val Glu Glu Ile Asp Ala 
                165                 170                 175     


Val Lys Ile Tyr Lys Val Lys Arg Phe Leu Ser Tyr Arg Ser Asn Met 
            180                 185                 190         


Leu Leu Phe Phe Ala Leu Ile Asn Asp Phe Leu Cys Lys Asn Leu Lys 
        195                 200                 205             


Asn Lys Lys Gly Glu Lys Ile Asn Glu Ile Trp Lys Met Glu Asn Lys 
    210                 215                 220                 


Gly Asn Asn Lys Lys Ile Asp Phe Asp Glu Asn Tyr Asn Ile Leu Val 
225                 230                 235                 240 


Ala Gln Ile Lys Glu Tyr Phe Thr Lys Glu Ile Glu Asn Tyr Asn Asn 
                245                 250                 255     


Arg Ile Asp Asn Ile Ile Asp Lys Lys Glu Leu Leu Lys Tyr Ser Glu 
            260                 265                 270         


Lys Lys Glu Glu Ser Glu Lys Asn Lys Lys Leu Glu Glu Leu Asn Lys 
        275                 280                 285             


Leu Lys Ser Gln Lys Leu Lys Ile Leu Thr Asp Glu Glu Ile Lys Ala 
    290                 295                 300                 


Asp Val Ile Lys Ile Ile Lys Ile Phe Ser Asp Leu Arg His Ser Leu 
305                 310                 315                 320 


Met His Tyr Glu Tyr Lys Tyr Phe Glu Asn Leu Phe Glu Asn Lys Lys 
                325                 330                 335     


Asn Glu Glu Leu Ala Glu Leu Leu Asn Leu Asn Leu Phe Lys Asn Leu 
            340                 345                 350         


Thr Leu Leu Arg Gln Met Lys Ile Glu Asn Lys Thr Asn Tyr Leu Glu 
        355                 360                 365             


Gly Arg Glu Glu Phe Asn Ile Ile Gly Lys Asn Ile Lys Ala Lys Glu 
    370                 375                 380                 


Val Leu Gly His Tyr Asn Leu Leu Ala Glu Gln Lys Asn Gly Phe Asn 
385                 390                 395                 400 


Asn Phe Ile Asn Ser Phe Phe Val Gln Asp Gly Thr Glu Asn Leu Glu 
                405                 410                 415     


Phe Lys Lys Leu Ile Asp Glu His Phe Val Asn Ala Lys Lys Arg Leu 
            420                 425                 430         


Glu Arg Asn Ile Lys Lys Ser Lys Lys Leu Glu Lys Glu Leu Glu Lys 
        435                 440                 445             


Met Glu Gln His Tyr Gln Arg Leu Asn Cys Ala Tyr Val Trp Asp Ile 
    450                 455                 460                 


His Thr Ser Thr Thr Tyr Lys Lys Leu Tyr Asn Lys Arg Lys Ser Leu 
465                 470                 475                 480 


Ile Glu Glu Tyr Asn Lys Gln Ile Asn Glu Ile Lys Asp Lys Glu Val 
                485                 490                 495     


Ile Thr Ala Ile Asn Val Glu Leu Leu Arg Ile Lys Lys Glu Met Glu 
            500                 505                 510         


Glu Ile Thr Lys Ser Asn Ser Leu Phe Arg Leu Lys Tyr Lys Met Gln 
        515                 520                 525             


Ile Ala Tyr Ala Phe Leu Glu Ile Glu Phe Gly Gly Asn Ile Ala Lys 
    530                 535                 540                 


Phe Lys Asp Glu Phe Asp Cys Ser Lys Met Glu Glu Val Gln Lys Tyr 
545                 550                 555                 560 


Leu Lys Lys Gly Val Lys Tyr Leu Lys Tyr Tyr Lys Asp Lys Glu Ala 
                565                 570                 575     


Gln Lys Asn Tyr Glu Phe Pro Phe Glu Glu Ile Phe Glu Asn Lys Asp 
            580                 585                 590         


Thr His Asn Glu Glu Trp Leu Glu Asn Thr Ser Glu Asn Asn Leu Phe 
        595                 600                 605             


Lys Phe Tyr Ile Leu Thr Tyr Leu Leu Leu Pro Met Glu Phe Lys Gly 
    610                 615                 620                 


Asp Phe Leu Gly Val Val Lys Lys His Tyr Tyr Asp Ile Lys Asn Val 
625                 630                 635                 640 


Asp Phe Thr Asp Glu Ser Glu Lys Glu Leu Ser Gln Val Gln Leu Asp 
                645                 650                 655     


Lys Met Ile Gly Asp Ser Phe Phe His Lys Ile Arg Leu Phe Glu Lys 
            660                 665                 670         


Asn Thr Lys Arg Tyr Glu Ile Ile Lys Tyr Ser Ile Leu Thr Ser Asp 
        675                 680                 685             


Glu Ile Lys Arg Tyr Phe Arg Leu Leu Glu Leu Asp Val Pro Tyr Phe 
    690                 695                 700                 


Glu Tyr Glu Lys Gly Thr Asp Glu Ile Gly Ile Phe Asn Lys Asn Ile 
705                 710                 715                 720 


Ile Leu Thr Ile Phe Lys Tyr Tyr Gln Ile Ile Phe Arg Leu Tyr Asn 
                725                 730                 735     


Asp Leu Glu Ile His Gly Leu Phe Asn Ile Ser Ser Asp Leu Asp Lys 
            740                 745                 750         


Ile Leu Arg Asp Leu Lys Ser Tyr Gly Asn Lys Asn Ile Asn Phe Arg 
        755                 760                 765             


Glu Phe Leu Tyr Val Ile Lys Gln Asn Asn Asn Ser Ser Thr Glu Glu 
    770                 775                 780                 


Glu Tyr Arg Lys Ile Trp Glu Asn Leu Glu Ala Lys Tyr Leu Arg Leu 
785                 790                 795                 800 


His Leu Leu Thr Pro Glu Lys Glu Glu Ile Lys Thr Lys Thr Lys Glu 
                805                 810                 815     


Glu Leu Glu Lys Leu Asn Glu Ile Ser Asn Leu Arg Asn Gly Ile Cys 
            820                 825                 830         


His Leu Asn Tyr Lys Glu Ile Ile Glu Glu Ile Leu Lys Thr Glu Ile 
        835                 840                 845             


Ser Glu Lys Asn Lys Glu Ala Thr Leu Asn Glu Lys Ile Arg Lys Val 
    850                 855                 860                 


Ile Asn Phe Ile Lys Glu Asn Glu Leu Asp Lys Val Glu Leu Gly Phe 
865                 870                 875                 880 


Asn Phe Ile Asn Asp Phe Phe Met Lys Lys Glu Gln Phe Met Phe Gly 
                885                 890                 895     


Gln Ile Lys Gln Val Lys Glu Gly Asn Ser Asp Ser Ile Thr Thr Glu 
            900                 905                 910         


Arg Glu Arg Lys Glu Lys Asn Asn Lys Lys Leu Lys Glu Thr Tyr Glu 
        915                 920                 925             


Leu Asn Cys Asp Asn Leu Ser Glu Phe Tyr Glu Thr Ser Asn Asn Leu 
    930                 935                 940                 


Arg Glu Arg Ala Asn Ser Ser Ser Leu Leu Glu Asp Ser Ala Phe Leu 
945                 950                 955                 960 


Lys Lys Ile Gly Leu Tyr Lys Val Lys Asn Asn Lys Val Asn Ser Lys 
                965                 970                 975     


Val Lys Asp Glu Glu Lys Arg Ile Glu Asn Ile Lys Arg Lys Leu Leu 
            980                 985                 990         


Lys Asp Ser Ser Asp Ile Met Gly  Met Tyr Lys Ala Glu  Val Val Lys 
        995                 1000                 1005             


Lys Leu  Lys Glu Lys Leu Ile  Leu Ile Phe Lys His  Asp Glu Glu 
    1010                 1015                 1020             


Lys Arg  Ile Tyr Val Thr Val  Tyr Asp Thr Ser Lys  Ala Val Pro 
    1025                 1030                 1035             


Glu Asn  Ile Ser Lys Glu Ile  Leu Val Lys Arg Asn  Asn Ser Lys 
    1040                 1045                 1050             


Glu Glu  Tyr Phe Phe Glu Asp  Asn Asn Lys Lys Tyr  Val Thr Glu 
    1055                 1060                 1065             


Tyr Tyr  Thr Leu Glu Ile Thr  Glu Thr Asn Glu Leu  Lys Val Ile 
    1070                 1075                 1080             


Pro Ala  Lys Lys Leu Glu Gly  Lys Glu Phe Lys Thr  Glu Lys Asn 
    1085                 1090                 1095             


Lys Glu  Asn Lys Leu Met Leu  Asn Asn His Tyr Cys  Phe Asn Val 
    1100                 1105                 1110             


Lys Ile  Ile Tyr 
    1115         


<210>  2776
<211>  1117
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2776

Met Glu Asn Lys Asn Lys Thr Lys Pro Asn Arg Gly Ser Ile Val Arg 
1               5                   10                  15      


Ile Ile Ile Ser Asn Tyr Asp Thr Lys Gly Ile Lys Glu Ile Lys Val 
            20                  25                  30          


Arg Tyr Arg Lys Gln Ala Gln Leu Asp Thr Phe Ile Leu Gln Thr Thr 
        35                  40                  45              


Leu Asp Lys Gly Asn Asn Ser Ile Leu Ile Ser Glu Phe Arg Val Lys 
    50                  55                  60                  


Ala Arg Glu Lys Asn Arg Tyr Ser Phe Thr Tyr Asp Gly Lys Glu Lys 
65                  70                  75                  80  


Phe Ser Ala Pro Ser Asn Ser Val Val Ile Thr Lys Ile Asp Asn Ala 
                85                  90                  95      


Ala Pro Glu Lys Phe Lys Glu Ile Arg Lys Tyr Lys Ile Thr Leu Glu 
            100                 105                 110         


Ile Asp Glu Lys Cys Lys Thr Gly Asn Met Ile Thr Ala Ala Ile Glu 
        115                 120                 125             


Asp Leu Leu Glu Asp Asp Ile Ala Arg Glu Gly Ile Arg Asn Pro Arg 
    130                 135                 140                 


Arg Lys Ala Ser Lys Thr Glu Arg Lys Leu Ile Ala Glu Ser Ile Cys 
145                 150                 155                 160 


His Asn Tyr Ala Gln Ile Ala Gln Cys Pro Val Glu Glu Ile Asp Ala 
                165                 170                 175     


Val Lys Ile Tyr Lys Val Lys Arg Phe Leu Ser Tyr Arg Ser Asn Met 
            180                 185                 190         


Leu Leu Phe Phe Ala Leu Ile Asn Asp Phe Leu Cys Lys Asn Leu Lys 
        195                 200                 205             


Asn Lys Lys Gly Glu Lys Ile Asn Glu Ile Trp Lys Met Glu Asn Lys 
    210                 215                 220                 


Gly Asn Asn Lys Lys Ile Asp Phe Asp Glu Asn Tyr Asn Ile Leu Val 
225                 230                 235                 240 


Ala Gln Ile Lys Glu Tyr Phe Thr Lys Glu Ile Glu Asn Tyr Asn Asn 
                245                 250                 255     


Arg Ile Asp Asn Ile Ile Asp Lys Lys Glu Leu Leu Lys Tyr Ser Glu 
            260                 265                 270         


Lys Lys Glu Glu Ser Glu Lys Asn Lys Lys Leu Glu Glu Leu Asn Lys 
        275                 280                 285             


Leu Lys Ser Gln Lys Leu Lys Ile Leu Thr Asp Glu Glu Ile Lys Ala 
    290                 295                 300                 


Asp Val Ile Lys Ile Ile Lys Ile Phe Ser Asp Leu Arg His Ser Leu 
305                 310                 315                 320 


Met His Tyr Glu Tyr Lys Tyr Phe Glu Asn Leu Phe Glu Asn Lys Lys 
                325                 330                 335     


Asn Glu Glu Leu Ala Glu Leu Leu Asn Leu Asn Leu Phe Lys Asn Leu 
            340                 345                 350         


Thr Leu Leu Arg Gln Met Lys Ile Glu Asn Lys Thr Asn Tyr Leu Glu 
        355                 360                 365             


Gly Arg Glu Glu Phe Asn Ile Ile Gly Lys Asn Ile Lys Ala Lys Glu 
    370                 375                 380                 


Val Leu Gly His Tyr Asn Leu Leu Ala Glu Gln Lys Asn Gly Phe Asn 
385                 390                 395                 400 


Asn Phe Ile Asn Ser Phe Phe Val Gln Asp Gly Thr Glu Asn Leu Glu 
                405                 410                 415     


Phe Lys Lys Leu Ile Asp Glu His Phe Val Asn Ala Lys Lys Arg Leu 
            420                 425                 430         


Glu Arg Asn Ile Lys Lys Ser Lys Lys Leu Glu Lys Glu Leu Glu Lys 
        435                 440                 445             


Met Glu Gln His Tyr Gln Arg Leu Asn Cys Ala Tyr Val Trp Asp Ile 
    450                 455                 460                 


His Thr Ser Thr Thr Tyr Lys Lys Leu Tyr Asn Lys Arg Lys Ser Leu 
465                 470                 475                 480 


Ile Glu Glu Tyr Asn Lys Gln Ile Asn Glu Ile Lys Asp Lys Glu Val 
                485                 490                 495     


Ile Thr Ala Ile Asn Val Glu Leu Leu Arg Ile Lys Lys Glu Met Glu 
            500                 505                 510         


Glu Ile Thr Lys Ser Asn Ser Leu Phe Arg Leu Lys Tyr Lys Met Gln 
        515                 520                 525             


Ile Ala Tyr Ala Phe Leu Glu Ile Glu Phe Gly Gly Asn Ile Ala Lys 
    530                 535                 540                 


Phe Lys Asp Glu Phe Asp Cys Ser Lys Met Glu Glu Val Gln Lys Tyr 
545                 550                 555                 560 


Leu Lys Lys Gly Val Lys Tyr Leu Lys Tyr Tyr Lys Asp Lys Glu Ala 
                565                 570                 575     


Gln Lys Asn Tyr Glu Phe Pro Phe Glu Glu Ile Phe Glu Asn Lys Asp 
            580                 585                 590         


Thr His Asn Glu Glu Trp Leu Glu Asn Thr Ser Glu Asn Asn Leu Phe 
        595                 600                 605             


Lys Phe Tyr Ile Leu Thr Tyr Leu Leu Leu Pro Met Glu Phe Lys Gly 
    610                 615                 620                 


Asp Phe Leu Gly Val Val Lys Lys His Tyr Tyr Asp Ile Lys Asn Val 
625                 630                 635                 640 


Asp Phe Thr Asp Glu Ser Glu Lys Glu Leu Ser Gln Val Gln Leu Asp 
                645                 650                 655     


Lys Met Ile Gly Asp Ser Phe Phe His Lys Ile Arg Leu Phe Glu Lys 
            660                 665                 670         


Asn Thr Lys Arg Tyr Glu Ile Ile Lys Tyr Ser Ile Leu Thr Ser Asp 
        675                 680                 685             


Glu Ile Lys Arg Tyr Phe Arg Leu Leu Glu Leu Asp Val Pro Tyr Phe 
    690                 695                 700                 


Glu Tyr Glu Lys Gly Thr Asp Glu Ile Gly Ile Phe Asn Lys Asn Ile 
705                 710                 715                 720 


Ile Leu Thr Ile Phe Lys Tyr Tyr Gln Ile Ile Phe Arg Leu Tyr Asn 
                725                 730                 735     


Asp Leu Glu Ile His Gly Leu Phe Asn Ile Ser Ser Asp Leu Asp Lys 
            740                 745                 750         


Ile Leu Arg Asp Leu Lys Ser Tyr Gly Asn Lys Asn Ile Asn Phe Arg 
        755                 760                 765             


Glu Phe Leu Tyr Val Ile Lys Gln Asn Asn Asn Ser Ser Thr Glu Glu 
    770                 775                 780                 


Glu Tyr Arg Lys Ile Trp Glu Asn Leu Glu Ala Lys Tyr Leu Arg Leu 
785                 790                 795                 800 


His Leu Leu Thr Pro Glu Lys Glu Glu Ile Lys Thr Lys Thr Lys Glu 
                805                 810                 815     


Glu Leu Glu Lys Leu Asn Glu Ile Ser Asn Leu Arg Asn Gly Ile Cys 
            820                 825                 830         


His Leu Asn Tyr Lys Glu Ile Ile Glu Glu Ile Leu Lys Thr Glu Ile 
        835                 840                 845             


Ser Glu Lys Asn Lys Glu Ala Thr Leu Asn Glu Lys Ile Arg Lys Val 
    850                 855                 860                 


Ile Asn Phe Ile Lys Glu Asn Glu Leu Asp Lys Val Glu Leu Gly Phe 
865                 870                 875                 880 


Asn Phe Ile Asn Asp Phe Phe Met Lys Lys Glu Gln Phe Met Phe Gly 
                885                 890                 895     


Gln Ile Lys Gln Val Lys Glu Gly Asn Ser Asp Ser Ile Thr Thr Glu 
            900                 905                 910         


Arg Glu Arg Lys Glu Lys Asn Asn Lys Lys Leu Lys Glu Thr Tyr Glu 
        915                 920                 925             


Leu Asn Cys Asp Asn Leu Ser Glu Phe Tyr Glu Thr Ser Asn Asn Leu 
    930                 935                 940                 


Arg Glu Arg Ala Asn Ser Ser Ser Leu Leu Glu Asp Ser Ala Phe Leu 
945                 950                 955                 960 


Lys Lys Ile Gly Leu Tyr Lys Val Lys Asn Asn Lys Val Asn Ser Lys 
                965                 970                 975     


Val Lys Asp Glu Glu Lys Arg Ile Glu Asn Ile Lys Arg Lys Leu Leu 
            980                 985                 990         


Lys Asp Ser Ser Asp Ile Met Gly  Met Tyr Lys Ala Glu  Val Val Lys 
        995                 1000                 1005             


Lys Leu  Lys Glu Lys Leu Ile  Leu Ile Phe Lys His  Asp Glu Glu 
    1010                 1015                 1020             


Lys Arg  Ile Tyr Val Thr Val  Tyr Asp Thr Ser Lys  Ala Val Pro 
    1025                 1030                 1035             


Glu Asn  Ile Ser Lys Glu Ile  Leu Val Lys Arg Asn  Asn Ser Lys 
    1040                 1045                 1050             


Glu Glu  Tyr Phe Phe Glu Asp  Asn Asn Lys Lys Tyr  Val Thr Glu 
    1055                 1060                 1065             


Tyr Tyr  Thr Leu Glu Ile Thr  Glu Thr Asn Glu Leu  Lys Val Ile 
    1070                 1075                 1080             


Pro Ala  Lys Lys Leu Glu Gly  Lys Glu Phe Lys Thr  Glu Lys Asn 
    1085                 1090                 1095             


Lys Glu  Asn Lys Leu Met Leu  Asn Asn His Tyr Cys  Phe Asn Val 
    1100                 1105                 1110             


Lys Ile  Ile Tyr 
    1115         


<210>  2777
<211>  1064
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2777

Met Val Tyr Asn Val Leu Ser Cys Asn Ile Lys Lys Lys Ile Ser Ile 
1               5                   10                  15      


Asn Tyr Arg Gly Gln Phe Met Ser Ile Asn Arg Val Lys Lys Val Lys 
            20                  25                  30          


Ser Asn Lys Gly Ser Ile Val Arg Val Ile Ile Ser Asn Phe Asp Asp 
        35                  40                  45              


Lys Arg Val Lys Glu Ile Lys Val Leu Tyr Ser Lys His Gly Gly Val 
    50                  55                  60                  


Asp Val Ile Arg Leu Lys Asp Thr Glu Pro Asp Glu Asn Gly Asp Met 
65                  70                  75                  80  


Lys Leu Val Phe Asp Tyr Ala Tyr Asn Arg Tyr Glu Asp Glu Asp Thr 
                85                  90                  95      


Tyr Val Thr Glu Glu Ser Glu Lys Gln Ser Phe Ile Val Thr Pro Asn 
            100                 105                 110         


Gly Asn Ser Thr Lys Leu His Phe Val Lys Lys Asn Glu Ala Thr Gly 
        115                 120                 125             


Ala Val Leu Arg Glu Tyr Thr Ile Gln Gly Lys Tyr Glu Thr Leu Lys 
    130                 135                 140                 


Ser Gly Lys Ala Lys Val Thr Val Ser Ile Asn Asp Ile Met Val Tyr 
145                 150                 155                 160 


Asp Asn Ser Asn Ala Ser Asp Leu Ile Arg Ala Lys Arg Thr Leu Val 
                165                 170                 175     


Gln Asp Thr Asn Arg Ile Leu Leu Ser Ala Asp Thr Ile Asp Tyr Tyr 
            180                 185                 190         


Arg Gln Ile Ala Ser Gly Asn Leu Asp Glu Ile Asn Asn Ala Leu Glu 
        195                 200                 205             


Ile Asp Ser Gln Glu Ile Tyr Lys Ile Asn Lys Phe Leu Ser Tyr Arg 
    210                 215                 220                 


Ser Asp Met Ile Ile Tyr Phe Gln Met Ile Asn Asn Phe Leu Leu Tyr 
225                 230                 235                 240 


Asn Ser Asp Ile Glu Glu Ile Tyr Glu Tyr Glu Lys Lys Asp Val Asp 
                245                 250                 255     


Lys Asn Asn Ile Leu Asn Asn Cys Leu Glu Asn Ile Ile Lys Asn Gln 
            260                 265                 270         


Ser Ser Leu Ile Asn Ile Tyr Gly Gly Asp Ile Lys Glu Ile Asp Glu 
        275                 280                 285             


Lys Ile Asn Ile Asp Lys Ile Leu Val Lys Gln Asp Leu Glu Lys Ile 
    290                 295                 300                 


Ile Leu Leu Leu Thr Lys Leu Arg His Ala Met Leu His Tyr Asp Tyr 
305                 310                 315                 320 


Thr Phe Trp Lys Ser Leu Tyr Ser Gly Glu Asp Phe Ile Leu Thr Phe 
                325                 330                 335     


Glu Lys Asp Asn Asp Lys Lys Val Pro Val Ser Glu Leu Leu Asp Leu 
            340                 345                 350         


Asn Ile Phe Lys Glu Leu Arg Lys Ile Lys Leu Val Lys Asp Lys Ala 
        355                 360                 365             


Val Thr Asn Tyr Leu Asp Lys Ser Ser Lys Ile Tyr Val Leu Gly Arg 
    370                 375                 380                 


Asn Val Asn Ala Ile Lys Ala Leu Asp Met Tyr Arg Asp Ile Cys Asp 
385                 390                 395                 400 


Lys Lys Leu Gly Phe Asn Lys Leu Val Asn Ser Ile Ile Thr Ser Ser 
                405                 410                 415     


Gly Glu Glu Asn Lys Glu Tyr Lys Arg Ile Val Thr Glu His Phe Asn 
            420                 425                 430         


Asn Ser Ile Thr Asn Met Asn Ser Phe Leu Glu Lys Leu Lys Asn Glu 
        435                 440                 445             


Asp Asp Phe Lys Thr Asn Trp Lys Lys Lys Lys Thr Tyr Asn Leu Ile 
    450                 455                 460                 


Lys Gln Arg Tyr Asp Glu His Gln Lys Leu Ser Lys Trp Phe Gly Gly 
465                 470                 475                 480 


Pro Tyr Val Tyr Asp Ile His Asp Ser Lys Ala Tyr Lys Glu Leu Tyr 
                485                 490                 495     


Ile Glu Arg Lys Asn Leu Val His Arg His Thr Lys Leu Ile Glu Lys 
            500                 505                 510         


Gly Ile Asp Asp Thr Asn Lys Lys Glu Phe Ile Glu Ile Asn Glu Glu 
        515                 520                 525             


Leu Ser Lys Leu Asn Lys Asp Met Lys Ala Met Thr Thr Ile Asn Ser 
    530                 535                 540                 


Thr Tyr Arg Leu Gln Tyr Lys Met Gln Leu Phe Phe Gly Phe Ile Ser 
545                 550                 555                 560 


Glu Lys Tyr Asn Leu Gln Val Asp Lys Phe Leu Asn Asp Phe Asp Leu 
                565                 570                 575     


Asn Asn Asp Asp Phe Arg Lys Val Phe Ile Glu Asn Tyr Asp Leu Tyr 
            580                 585                 590         


Ile Asn Lys Thr Leu Glu Lys Gln Asp Lys Asn Leu Asn Asn Leu Ile 
        595                 600                 605             


Lys Asp Tyr Thr Cys Arg Asp Thr Glu Asp Ile Phe Phe Glu Asp Arg 
    610                 615                 620                 


Asp Asn Asn Leu Val Lys Leu Tyr Ile Val Met His Leu Leu Leu Pro 
625                 630                 635                 640 


Ser Glu Ile Arg Gly Asp Phe Leu Gly His Val Lys Lys Asn Tyr Tyr 
                645                 650                 655     


Asp Met Lys His Val Asp Phe Ile Asp Lys Glu Asp Lys Ser Glu Gly 
            660                 665                 670         


Asp Thr Phe Phe His Asp Leu Arg Leu Phe Glu Lys Asn Ala Arg Lys 
        675                 680                 685             


Leu Glu Ile Val Asp Tyr Ser Leu Ser Gln Met Phe Leu Thr Lys Asp 
    690                 695                 700                 


Asp Asn Asn Tyr Ile Glu Glu Lys Leu Asn Glu Leu Ile Leu Asn Lys 
705                 710                 715                 720 


Tyr Asp Ile Glu Leu Pro Glu Asp Ile Asn Ile Lys Gln Phe Tyr Lys 
                725                 730                 735     


Ser Phe Met Leu Pro Leu Ile Lys Asn Tyr Gln Ile Ile Phe Lys Leu 
            740                 745                 750         


Leu Asn Asp Ile Glu Ile Lys Gly Leu Phe Lys Ile Ser Lys Asp Glu 
        755                 760                 765             


Asn Ile Ser Leu Lys Glu Ala Ile Asn Lys Cys Arg Ile Asn Asp His 
    770                 775                 780                 


Ile Asn Phe Ser Lys Ile Met Arg Leu Ser Leu Asn Glu Gln Gly Pro 
785                 790                 795                 800 


Asn Lys Lys Asn Ile Tyr Ala Ile Arg Asn Ser Ile Ala His Ile Asp 
                805                 810                 815     


Met Lys Glu Leu Tyr Ile Asp Pro Leu Asp Ile Tyr Ile Asp Pro Leu 
            820                 825                 830         


Asp Ile Tyr Ile Gly Ile Asn Asn Gly Glu Thr Ile Ser Glu Lys Ile 
        835                 840                 845             


Glu His Ile Ile Glu Arg Trp Val Lys Glu Glu Thr Val Gly Lys Glu 
    850                 855                 860                 


Leu Asn Lys Ser Ile Ile Asn Asp Tyr Tyr Met Lys Lys Glu Glu Leu 
865                 870                 875                 880 


Val Leu Tyr Leu Lys Leu Gly Glu His Asn Asn Val Val Ile Asp Ala 
                885                 890                 895     


Gln Glu Glu Ser Lys Arg Lys Glu Thr Val Leu Arg Lys Tyr Arg Leu 
            900                 905                 910         


Glu Asn Asn Asn Val Asp Thr Gln Ile Lys Lys Val Ile Glu Lys Ile 
        915                 920                 925             


Lys Val Leu Lys Glu Glu Ser Gln Thr Phe Gly Glu Lys Asp Lys Gln 
    930                 935                 940                 


Lys Lys Val Leu Tyr Asn Asp Ile Ser Asp Leu Thr Gly Ile Val Arg 
945                 950                 955                 960 


Arg Tyr Ile Ser Leu Lys Ile Lys Lys Ile Leu Leu Asp Ile Ile Arg 
                965                 970                 975     


Arg Gly Glu Tyr Arg Tyr Val Asn Ile Asn Ile Tyr Asp Lys Glu Thr 
            980                 985                 990         


Gly Ser Asn Val Asn Lys Glu Ile  Lys Ile Lys Tyr Cys  Ile Asn Lys 
        995                 1000                 1005             


Gly Glu  Glu Ile Tyr Thr Val  Asn Ser Asp Ala Val  Asp Asp Phe 
    1010                 1015                 1020             


Asn Phe  Glu Ile Asn Asn Lys  Ser Leu Ile Ile Lys  Phe Asp Lys 
    1025                 1030                 1035             


Asp Arg  His Pro Glu Lys Arg  Val Gln Thr Ile Asn  Leu Glu Ser 
    1040                 1045                 1050             


Asn Tyr  Ile Gln Asn Ala Lys  Phe Ile Val Ser 
    1055                 1060                 


<210>  2778
<211>  1071
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2778

Leu Ile Glu Lys Ile Tyr Leu Gly Lys Lys Arg Asp Phe Met Ser Ile 
1               5                   10                  15      


Gly Asp Glu Lys Lys Leu Lys Pro Asn Lys Ser Ser Ile Ile Arg Val 
            20                  25                  30          


Met Ile Ser Asn Phe Asp Asp Lys Gln Ile Lys Glu Ile Lys Val Leu 
        35                  40                  45              


Tyr Asn Lys Gln Gly Gly Val Asp Val Ile Arg Leu Asn Gly Thr Glu 
    50                  55                  60                  


Pro Asp Glu Lys Gly Arg Met Lys Phe Asn Phe Asn Tyr Ala Tyr Asn 
65                  70                  75                  80  


Arg Leu Glu Asp Glu Lys Thr Asn Ser Leu Glu Glu Met Asp Glu Gln 
                85                  90                  95      


Ser Phe Phe Val Thr Thr Asn Glu Asp Ile Thr Glu Leu Tyr Ile Thr 
            100                 105                 110         


Lys Lys His Lys Met Thr Gly Glu Ile Ile Lys Lys Tyr Thr Leu His 
        115                 120                 125             


Gly Lys Tyr Ile Phe Leu Asn Ser Asn Lys Thr Lys Val Ile Val Ser 
    130                 135                 140                 


Ile Val Asp Asn Ile Asp His Ser Val Thr Lys Asp Leu Ser Asp Met 
145                 150                 155                 160 


Ile Arg Ser Pro Arg Ser Leu Thr Gln Asp Thr Asn Arg Val Leu Leu 
                165                 170                 175     


Asp Thr Glu Val Met Lys Asn Tyr Arg Gln Ile Ile Cys Ser Asp Leu 
            180                 185                 190         


Glu Arg Ile Asp Glu Thr Ile Lys Met Asp Ser Gln Glu Ile Tyr Lys 
        195                 200                 205             


Ile Asn Arg Phe Leu Ser Tyr Arg Ser Asp Met Ile Val Tyr Tyr Gln 
    210                 215                 220                 


Met Ile Asn Asn Phe Leu Leu His Tyr Asp Gly Glu Glu Gly Ile Asp 
225                 230                 235                 240 


Asn Lys Ser Ser Gln Asp Asn Ser Gly Lys Asp Asp Asn Lys Asn Leu 
                245                 250                 255     


Ile Asn Glu Ile Trp Gln Tyr Glu Asp Lys Lys Asp Asp Glu Lys Asn 
            260                 265                 270         


Lys Ile Val Glu Arg Ser Tyr Arg Ser Ile Glu Lys Ser Ile Asn Gln 
        275                 280                 285             


Phe Ile Leu Asn His Asn Asn Lys Val Glu Lys Asp Lys Lys Gly Glu 
    290                 295                 300                 


Lys Ile Asp Ile Ser Gln Glu Met Ile Glu Glu Asp Leu Arg Lys Ile 
305                 310                 315                 320 


Leu Met Leu Phe Ser Lys Leu Arg His Ser Met Val His Tyr Asn Tyr 
                325                 330                 335     


Glu Phe Tyr Gln Ala Leu Tyr Ser Gly Lys Asp Phe Val Ile Ser Ser 
            340                 345                 350         


Lys Asn Asp Ser Glu Asn Arg Met Ile Ser Gln Leu Leu Asp Leu Asn 
        355                 360                 365             


Ile Phe Lys Glu Leu Ser Lys Ile Lys Leu Ile Lys Asp Lys Asp Ile 
    370                 375                 380                 


Ser Asn Tyr Leu Asp Lys Asn Thr Thr Val His Val Leu Gly Gln Asn 
385                 390                 395                 400 


Ile Asn Ala Met Arg Leu Leu Asp Ile Tyr Arg Asp Ile Cys Glu Ser 
                405                 410                 415     


Lys Asn Gly Phe Asn Lys Phe Ile Asn Ala Met Ile Thr Ile Ser Gly 
            420                 425                 430         


Glu Glu Asp Arg Glu Tyr Lys Glu Lys Ile Ile Glu His Phe Asn Lys 
        435                 440                 445             


Lys Ile Asp Asp Leu Phe Asn Tyr Leu Lys Lys Leu Glu Lys Lys Tyr 
    450                 455                 460                 


Gly Ala Lys Arg Asn Asn Lys Arg Asp Tyr Asn Ser Leu Met Gln Thr 
465                 470                 475                 480 


Leu Val Glu Gln Gln Lys Leu Lys Glu Trp Phe Gly Gly Pro Tyr Val 
                485                 490                 495     


Tyr Asp Ile His Ser Ser Lys Arg Tyr Lys Glu Leu Tyr Ile Glu Arg 
            500                 505                 510         


Lys Lys Leu Val Asp Arg His Ser Lys Leu Phe Lys Glu Gly Leu Asp 
        515                 520                 525             


Glu Lys Asn Lys Lys Glu Leu Thr Lys Ile Asn Val Glu Leu Ser Lys 
    530                 535                 540                 


Leu Asn Ser Glu Met Lys Glu Met Thr Lys Leu Asn Ser Lys Tyr Arg 
545                 550                 555                 560 


Leu Gln Tyr Lys Leu Gln Leu Ala Phe Gly Phe Ile Leu Glu Glu Phe 
                565                 570                 575     


Asp Leu Asn Ile Asp Thr Phe Ile Asn Asp Phe Asp Lys Asp Lys Asp 
            580                 585                 590         


Leu Ile Ile Ser Asn Phe Met Lys Lys Arg Asp Ile Tyr Leu Asn Arg 
        595                 600                 605             


Val Leu Asp Arg Gly Asn Asp Arg Leu Lys Asn Ile Val Lys Glu Tyr 
    610                 615                 620                 


Lys Phe Arg Asp Thr Glu Asp Ile Phe Cys Asn Asp Arg Asn Asn Asn 
625                 630                 635                 640 


Leu Ala Lys Leu Tyr Ile Leu Met Tyr Ile Leu Leu Pro Val Glu Ile 
                645                 650                 655     


Arg Gly Asp Phe Leu Gly Phe Val Lys Lys Asn Tyr Tyr Asp Met Lys 
            660                 665                 670         


His Val Asp Phe Ile Asp Arg Glu Asp Lys Asp Thr Phe Phe His Asp 
        675                 680                 685             


Leu Arg Leu Phe Glu Lys Asn Ile Arg Lys Leu Glu Val Ile Asn Tyr 
    690                 695                 700                 


Ser Leu Ser Ser Gly Phe Leu Ser Lys Glu His Lys Ala Asp Ile Glu 
705                 710                 715                 720 


Glu Lys Leu Asn Lys Phe Ile Asn Arg Asn Gly Ile Met Lys Leu Pro 
                725                 730                 735     


Glu Asn Ile Thr Ile Asp Glu Phe Asn Lys Ser Leu Ile Leu Pro Ile 
            740                 745                 750         


Met Lys Asn Tyr Gln Ile Ile Phe Lys Leu Leu Asn Asp Ile Glu Ile 
        755                 760                 765             


Ser Ala Leu Phe Lys Ile Ala Lys Asp Lys Asn Ile Thr Phe Lys Gln 
    770                 775                 780                 


Ala Ile Asp Glu Val Lys Asn Lys Asp Lys Tyr Lys Asn Ile Asn Phe 
785                 790                 795                 800 


Ser Gln Val Met Lys Met Ala Leu Asn Lys Gly Gly Ile Tyr Gln Ile 
                805                 810                 815     


Arg Asn Asn Ile Ser His Ile Asn Met Lys Gln Leu Tyr Ile Asp Pro 
            820                 825                 830         


Leu Asn Ser His Met Asn Asn Arg Lys Asp Ile Gly Thr Ile Ser Glu 
        835                 840                 845             


Gln Ile Glu Lys Val Ile Asp Val Cys Ile Thr Gly Gly Leu Thr Gly 
    850                 855                 860                 


Lys Glu Leu Asn Lys Asn Ile Ile Asn Asp Tyr Tyr Met Lys Lys Glu 
865                 870                 875                 880 


Lys Leu Val Phe Asn Leu Lys Leu Arg Lys Gln Asn Asp Thr Val Ser 
                885                 890                 895     


Ile Asp Leu Gln Glu Lys Asn Lys Glu Glu Glu Phe Val Phe Lys Lys 
            900                 905                 910         


Tyr Gly Leu Asp Tyr Lys Asp Gly Asp Ile Asn Ile Ile Glu Val Met 
        915                 920                 925             


Gln Lys Val Asn Lys Leu Glu Glu Glu Leu Lys Ser Ile Lys Glu Thr 
    930                 935                 940                 


Ser Lys Glu Lys Leu Lys Asn Lys Glu Thr Leu Phe Lys Asp Ile Ser 
945                 950                 955                 960 


Leu Ile Asn Gly Val Thr Arg Lys Asn Ile Asn Phe Lys Ile Lys Glu 
                965                 970                 975     


Ile Val Leu Asp Ile Ile Arg Met Gly Glu Ile Lys Arg Ile Asn Ile 
            980                 985                 990         


Asn Ile Tyr Tyr Lys Ser Glu Asn  Tyr Asn Lys Asn Thr  Ile Ile Lys 
        995                 1000                 1005             


Phe Lys  Tyr Thr Ile Asp Gly  Glu Asn Lys Lys Tyr  Tyr Phe Lys 
    1010                 1015                 1020             


Gln His  Lys Ile Ser Asp Val  Asp Leu Glu Leu Lys  Asn Lys Ser 
    1025                 1030                 1035             


Val Arg  Leu Thr Cys His Lys  Asp Lys Asp Pro Lys  Lys Asn Lys 
    1040                 1045                 1050             


Gln Thr  Ile Asn Leu Glu Ser  Asn Tyr Ile Gln Asn  Val Lys Phe 
    1055                 1060                 1065             


Ile Ile  Ser 
    1070     


<210>  2779
<211>  1238
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2779

Met Asn Gln Tyr Ile His Ala Asn Lys Lys Glu Asn Lys Lys Arg Pro 
1               5                   10                  15      


Asn Lys Ser Ser Ile Ile Arg Ile Met Val Ser Asp Phe Asp Asp Glu 
            20                  25                  30          


Tyr Ile Gln Glu Ile Lys Val Leu Tyr Ile Lys Gln Gly Gly Val Asp 
        35                  40                  45              


Thr Phe Lys Ile Asn Lys Met Ser Tyr Asp Ser Ala Ser Lys Lys Ile 
    50                  55                  60                  


Ile Phe Glu Glu Val Ala Thr Gln Asn Met Leu Ser Val Glu Asp Ser 
65                  70                  75                  80  


Asn Leu Asn Phe Lys Arg Pro Met Val Glu Cys Lys Asn Gly Asp Ile 
                85                  90                  95      


Tyr Val Val Lys Pro Ser Glu Lys Val Asn Glu Lys Gly Gln Ala Ile 
            100                 105                 110         


Glu Pro Leu Arg Ser Tyr Lys Ile His Gly Lys Tyr Leu Asp Leu Thr 
        115                 120                 125             


Glu Glu Ile Gly Lys Asp Asn Ala Glu Gln Ser Gly Lys Lys Gln Ile 
    130                 135                 140                 


Tyr Leu His Val Glu Asp Leu Leu Gly Met His Thr Thr Ala Asp Ser 
145                 150                 155                 160 


Ile Asp Arg Arg Arg Leu Glu Ser Glu Thr Gln Arg Thr Leu Leu Ser 
                165                 170                 175     


Lys Glu Val Met Glu Asn Tyr Ala Leu Ile Met Gly His Glu Ile Lys 
            180                 185                 190         


Leu Asp Glu Ser Asp Glu Thr Tyr Lys Leu Ala Ser Ser Lys Glu Ile 
        195                 200                 205             


Tyr Lys Ala Asn Arg Phe Leu Asp Tyr Arg Ser Arg Leu Leu Tyr Tyr 
    210                 215                 220                 


Tyr Ser Phe Ile Asn His Phe Leu Val Gly Leu Ser Lys Gly Ala Thr 
225                 230                 235                 240 


Tyr Glu Tyr Ala Gly Lys Ser Leu Val Ala Lys Ile Pro Asp Gly Glu 
                245                 250                 255     


Val Trp Gln Leu Cys Glu Leu Glu Val Thr Ala Tyr His Gly Ile Tyr 
            260                 265                 270         


Ile Asn Lys Lys Arg Asn Glu Leu Val Asn Glu Asn Ser Leu Lys Ile 
        275                 280                 285             


Asp Ala Ile Tyr Ala Gln Met Ala Lys Asn Met Lys Glu Thr Ile Asn 
    290                 295                 300                 


Glu Phe Val Asp Asn Tyr Asn Ala Met Ile Glu Lys Gln Asn Glu Leu 
305                 310                 315                 320 


Lys Asp Asn Lys Ser Tyr Lys Ile Asn Lys Lys Ala Gln Asn Thr Thr 
                325                 330                 335     


Lys Phe Glu Asn Phe Thr Glu Glu Lys Ile Asn Gln Asp Leu His Asn 
            340                 345                 350         


Ile Val Tyr Ile Leu Ser Asp Leu Arg His Lys Leu Met His Phe Glu 
        355                 360                 365             


Tyr His Tyr Phe Glu Leu Leu Met Thr Gly Lys Lys Met Gly Glu Lys 
    370                 375                 380                 


Ser Glu Val Ile Val Cys Val Pro Asp Arg Asn Ser Glu Leu Pro Ala 
385                 390                 395                 400 


Ser Lys Asn Glu Pro Ser Lys Asp Lys Phe Arg Lys Glu Lys Lys Leu 
                405                 410                 415     


Ser Glu Leu Leu Asp Leu Asn Ile Leu Lys Glu Leu Asp Thr Phe Val 
            420                 425                 430         


Lys Val Lys Glu Ser Tyr Gln Thr Thr Tyr Leu Glu Thr Asn Asp Lys 
        435                 440                 445             


Ile Glu Ile Leu Gly Lys Leu Lys Thr Ala Lys Ser Ile Tyr Gln Ile 
    450                 455                 460                 


Tyr His Gln Ile Cys Gln Arg Lys Asn Gly Phe Asn Lys Phe Ile Asn 
465                 470                 475                 480 


Ser Phe Phe Thr Val Asp Gly Glu Glu Asn Thr Glu Val Lys Asp Cys 
                485                 490                 495     


Ile Asn Glu Val Phe Arg Lys Glu Ile His Tyr Phe Glu Met Val Ile 
            500                 505                 510         


Ala Lys Ser Asn Glu Asp Thr Leu Asn Asp Lys Asn Lys Asn Lys Ser 
        515                 520                 525             


Lys Lys Thr Arg Asp Arg Met Lys Asn Gln Ile Gln Glu Cys Lys Arg 
    530                 535                 540                 


Tyr Gln Asp Asp Glu Ser Asn Ile Asp Thr Trp Val Ala Tyr His Lys 
545                 550                 555                 560 


Asp Ile His Tyr Ser Lys Arg Tyr Lys Lys Leu Tyr Cys Glu His Ile 
                565                 570                 575     


Thr Leu Val Asp Asn Leu Asn Ser Ala Val Ser Asn Gly Leu Asn Gly 
            580                 585                 590         


Gln Val Ile Lys Glu Ile Asn Asp Asp Ile Ala Ile Lys Lys Arg Glu 
        595                 600                 605             


Met Asn Glu Ile Thr Lys Ala Asn Ser Lys Ser Arg Leu Arg Tyr Lys 
    610                 615                 620                 


Met Gln Met Ala Tyr Gly Phe Leu Phe Val Glu Tyr Gly Leu Lys Ile 
625                 630                 635                 640 


Pro Lys Phe Leu Asn Asp Phe Asp Leu Ser His Val Arg Thr Ala Ser 
                645                 650                 655     


Lys Ile Lys Gly Tyr Lys Ser Pro Val Lys Val Thr Gln Tyr Leu Thr 
            660                 665                 670         


Asn Asp Glu Gly Asn Lys Asp Asn Phe Asn Leu Glu Thr Leu Met Glu 
        675                 680                 685             


Asp Ile Asp Lys Lys Ser Lys Ile Asn Phe Glu Phe Leu Lys Ser Asn 
    690                 695                 700                 


Glu Asp Asn Asn Leu Ile Lys Leu Tyr Ile Leu Ile Tyr Gln Leu Leu 
705                 710                 715                 720 


Pro Arg Glu Leu Lys Gly Asp Phe Leu Gly Phe Val Lys Asn Asn Tyr 
                725                 730                 735     


Tyr Asp Leu Lys His Val Asp Phe Gln Thr Arg Glu Thr Glu Ala Lys 
            740                 745                 750         


Asp Gln Phe Phe His Asn Met Arg Leu Phe Glu Lys Asn Val Lys Ala 
        755                 760                 765             


Phe Asp Leu Ile Gln Tyr Ser Ile Gly Asp Glu Met Ser Gln Leu Gly 
    770                 775                 780                 


Asn Glu Thr Phe Asn Phe Ser Gln Ala Leu Ser Lys Ile Val Ser Asp 
785                 790                 795                 800 


Asp Thr Ile Leu Asn Ser Ala Thr Glu Ile Pro Asn Ile Asn Arg Leu 
                805                 810                 815     


Val Tyr Gly Ser Leu Leu Lys Tyr Tyr Glu Asn Ala Phe Arg Leu Ser 
            820                 825                 830         


Ser Glu Ile Glu Ile Arg Ala Leu Ile Lys Ile Ala Arg Gly Lys Gln 
        835                 840                 845             


Ile Asp Asn His Ser Ile Asp Glu Ala Tyr Lys Asp Ala Leu Ile Phe 
    850                 855                 860                 


Gln Lys Ser Gly Gln Thr Val Lys Phe Ser Ser Ile Leu Lys Tyr Phe 
865                 870                 875                 880 


Asn Ile Asp Asp Leu Asn Lys Lys Asn Asp Ser Lys Ile Tyr Asn Lys 
                885                 890                 895     


Ala Ser Asn Leu Arg Asn Lys Ile Ala His Cys Asp Tyr Thr Val Leu 
            900                 905                 910         


Phe Ile Thr Asn Ile Ile Cys Glu Ala Glu Asn Ile Asn Val Lys Ala 
        915                 920                 925             


Lys Tyr Leu Ile Asp Val Ser Asn Lys Ile Gly Leu Asn Thr Val Asp 
    930                 935                 940                 


Leu Gly Asn Asp Met Val Asn Asp Tyr Leu Met Ser Tyr Asp Lys Gln 
945                 950                 955                 960 


Met Thr Tyr Leu Ala Lys Thr Ser Glu Glu Leu Leu Lys Glu Ser Ser 
                965                 970                 975     


Leu Asp Lys Ser Lys Glu Lys Lys Glu Arg Arg Asp Asn Leu Lys Asn 
            980                 985                 990         


Glu Thr Arg Ser His Ser Glu Ile  Tyr Met Glu Tyr Glu  Trp Ile Ser 
        995                 1000                 1005             


Asp Tyr  Leu Val Lys Leu Lys  Asp Asn His Glu Ile  Leu Ser Lys 
    1010                 1015                 1020             


Lys Asn  Lys Thr Glu Asp Leu  Lys Leu Asn Arg Ala  Tyr Glu Leu 
    1025                 1030                 1035             


Ile Lys  Asn Tyr Asn Val Ala  Leu Asn Lys Lys Ser  Lys Ile Lys 
    1040                 1045                 1050             


Ile Arg  Ala Leu Thr Thr Asp  His Ile Asn Asn Asn  Trp Val Asn 
    1055                 1060                 1065             


Ile Trp  Gly Ala Leu Thr His  Glu Leu Gln Glu Ile  Lys Gly Leu 
    1070                 1075                 1080             


Tyr Leu  Tyr Lys Val Thr Pro  Lys Ile Lys Lys Gly  Ile Tyr Phe 
    1085                 1090                 1095             


Val Leu  Thr Asp Lys Lys Asn  Tyr Cys Leu Asn Ile  Asn Leu Tyr 
    1100                 1105                 1110             


Thr Leu  Lys Lys Val Pro Ser  Lys Asp Asp Ser Glu  Met Thr Glu 
    1115                 1120                 1125             


Glu Arg  Tyr Leu Arg Asp Ile  Ser Glu Lys Tyr Tyr  Phe Thr Val 
    1130                 1135                 1140             


Gly Glu  Asp Ser Ile Lys Ala  Leu Lys Glu Arg Leu  Gln Thr Ile 
    1145                 1150                 1155             


Asn Asp  Lys Cys Ile Ile Thr  Tyr Val Asn Glu Ile  Asp Cys Lys 
    1160                 1165                 1170             


Asn Glu  Asn Ile Lys Glu Lys  Pro Glu Phe Lys Ile  Ala Glu Asp 
    1175                 1180                 1185             


Tyr Asn  Ser Trp Asp Lys Lys  Tyr Leu Ser Ile Ser  Asn Glu Glu 
    1190                 1195                 1200             


Leu His  His Trp Ser Val Glu  Thr Arg Arg Asp Lys  Lys Tyr Lys 
    1205                 1210                 1215             


Glu Asn  Leu Ile Leu Asn Leu  Met Glu Lys Ser Ser  Phe Lys Leu 
    1220                 1225                 1230             


Asn Leu  His Gln Leu 
    1235             


<210>  2780
<211>  1147
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2780

Met Glu Gly Gly Thr Lys Ile Lys Ala Asn Arg Ser Ser Ile Ile Arg 
1               5                   10                  15      


Ile Ile Ile Ser Asn Tyr Asp Ser Asn Gly Ile Lys Glu Ile Lys Val 
            20                  25                  30          


Arg Tyr Asn Lys Gln Ala Gln Leu Asp Thr Phe Leu Ile Glu Ser Lys 
        35                  40                  45              


Leu Glu Lys Gly Val Phe Thr Leu Lys Asp Val Lys Trp Lys Ala Lys 
    50                  55                  60                  


Glu Lys Asn Arg Tyr Asn Ile Ile Arg Glu Glu Ile Ile Asp Asn Ser 
65                  70                  75                  80  


Val Lys Ile Thr Lys Ile Asp Lys Leu Ser Asn Lys Ala Ile Arg Gly 
                85                  90                  95      


Tyr Ile Ile Lys Phe Ser Val Ser Pro Lys Asn Lys Asn Val Val Val 
            100                 105                 110         


Val Asp Ile Lys Asp Cys Met Glu His Asn Leu Thr Ile Lys Gly Glu 
        115                 120                 125             


Arg Ser Asn Thr Arg Arg Asp Thr Ser Gln Thr Glu Arg Lys Leu Leu 
    130                 135                 140                 


Ser Lys Glu Thr Gln Ile Thr Tyr Ser Lys Ile Ala Cys Cys Pro Pro 
145                 150                 155                 160 


Glu Asn Ile Asp Ser Leu Lys Ile Tyr Lys Ile Lys Arg Tyr Leu Ser 
                165                 170                 175     


Tyr Arg Ser Asn Met Leu Leu Phe Phe Ser Leu Ile Asn Asp Phe Ile 
            180                 185                 190         


Cys Glu Gly Ile Lys Lys Glu Lys Ile Val Glu Leu Tyr Lys Ile Thr 
        195                 200                 205             


Ser Lys Val Asp Glu Asn Ile Ile Glu Glu Arg Val Thr Lys Ile Ala 
    210                 215                 220                 


Gln Tyr Leu Arg Glu Asn Leu Ser Asn Glu Leu Lys Asn Tyr Asn Asn 
225                 230                 235                 240 


Gly Ile Glu Lys Thr Ile Ser Lys Lys Ser Asn Ser Ile Asn Asp Cys 
                245                 250                 255     


Asn Asn Arg Ile Glu Ser Cys Lys Lys Lys Ile Thr Lys Leu Asp Lys 
            260                 265                 270         


Ile Lys Asp Lys Lys Gln Ile Arg Asn Leu Glu Arg Ile Ile Gln Asp 
        275                 280                 285             


Ser Glu Asn Lys Ile Lys Glu Cys Asn Lys Ile Ile Ala Glu Lys Arg 
    290                 295                 300                 


Lys Glu Arg Leu Ile Ala Leu Ala Glu Glu Lys Ile Lys Glu Asp Val 
305                 310                 315                 320 


Tyr Lys Ile Leu Glu Leu Tyr Ser Asp Leu Arg His Lys Leu Ala His 
                325                 330                 335     


Tyr Asn Tyr Ala Tyr Phe Glu Asn Leu Phe Glu Asn Asn Val Glu Asp 
            340                 345                 350         


Ser Asn Met Val Asn Met Ala Lys Leu Leu Asp Leu Asn Ile Phe Lys 
        355                 360                 365             


Tyr Leu Glu Leu Ser Lys Lys Leu Arg Ile Glu Asn Lys Thr Asn Tyr 
    370                 375                 380                 


Leu Asp Asp Asp Thr Lys Phe Ser Ile Leu Gly Val Arg Gly Lys Ala 
385                 390                 395                 400 


Lys Lys Tyr Tyr Ser Ile Tyr Asn Thr Leu Cys Glu Gln Lys Asn Gly 
                405                 410                 415     


Phe Asn Thr Phe Ile Asn Asn Phe Phe Thr Lys Asp Gly Ile Glu Asp 
            420                 425                 430         


Ile Asp Phe Lys Asp Lys Val Asn Ala Arg Phe Lys Glu Glu Ile Lys 
        435                 440                 445             


Glu Leu Glu Glu Phe Glu Ala Lys Gln Lys Glu Lys Lys Lys Lys Phe 
    450                 455                 460                 


Lys Asp Lys Glu Leu Glu Leu Leu Lys Glu Gln Asp Thr Glu Leu Glu 
465                 470                 475                 480 


Thr Ala Tyr Val Trp Asp Ile His Asn Ser Ile Arg Tyr Lys Gly Phe 
                485                 490                 495     


Tyr Lys Asp Arg Lys Asp Ile Val Glu Lys Tyr Asn Gln Thr Leu Ser 
            500                 505                 510         


Gly Asn Arg Asn Lys Ile Ala Leu Arg Asp Tyr Gly Ala Lys Leu Leu 
        515                 520                 525             


Glu Ile Lys Asn Lys Met Asp Asn Ile Thr Lys Arg Asn Ser Ile Ile 
    530                 535                 540                 


Arg Leu Lys Tyr Lys Leu Gln Val Ala Tyr Ala Phe Leu Met Lys Glu 
545                 550                 555                 560 


Phe Asn Gly Asn Ile Ala Arg Phe Lys Ser Glu Phe Asp Val Ser Asn 
                565                 570                 575     


Val Glu Gln Val Glu Lys Tyr Gln Ala His Lys Lys Glu Tyr Leu Cys 
            580                 585                 590         


Tyr Thr Asp Lys Lys Asn Phe Asn Ile Glu Lys Phe Gln Glu Ile Leu 
        595                 600                 605             


Gly Glu Leu Glu Ala Ser Asn Lys Val Thr Trp Leu Ser Ser Asp Thr 
    610                 615                 620                 


Lys Asn Asn Leu Phe Lys Phe Tyr Val Leu Thr Tyr Ile Leu Leu Pro 
625                 630                 635                 640 


Phe Glu Phe Lys Gly Asp Phe Leu Gly Phe Val Lys Lys His Tyr Tyr 
                645                 650                 655     


Asp Ile Lys Asn Val Glu Tyr Leu Asp Glu Asn Asn Glu Glu Leu Thr 
            660                 665                 670         


Asn Glu Gln Leu Glu Lys Met Lys Asp Asp Ser Phe Phe Asn Lys Ile 
        675                 680                 685             


Arg Leu Phe Glu Lys Asn Ser Lys Lys Tyr Asn Ile Phe Ser Lys Ser 
    690                 695                 700                 


Phe Leu Thr Asn Glu Arg Val Lys Glu Tyr Phe Glu Lys Leu Asn Ile 
705                 710                 715                 720 


Gly Ala Lys His Tyr Glu Tyr Val Gly Ala Asn Gly Glu Thr Lys Gly 
                725                 730                 735     


Ile Phe Asn Lys Asn Ile Ile Ile Pro Ile Phe Lys Tyr Tyr Gln Ile 
            740                 745                 750         


Ile Ile Lys Leu Tyr Asn Asp Val Glu Ile Ala Ile Leu Leu Tyr Leu 
        755                 760                 765             


Ser Lys Leu Lys Gly Asp Ile Pro Ile Asp Glu Val Ile Asp Lys Val 
    770                 775                 780                 


Thr Gln Lys Gln Ser Ile Thr Glu Gly Arg Glu Leu Asp Phe Tyr Ser 
785                 790                 795                 800 


Leu Asn Gly Leu Phe Gly Phe Phe Lys Leu Ile Asn Asp Asn Leu Ala 
                805                 810                 815     


Glu Phe Asp Thr Thr Glu Lys Ile Pro Lys Asp Tyr Leu Lys Ser Glu 
            820                 825                 830         


Val Thr Phe Ile Arg Asn Lys Val Phe His Phe Asp Tyr Lys Asn Phe 
        835                 840                 845             


Ile Asp Asn Leu Leu Glu Ile Asp Cys Glu Asn Gly Ser Lys Phe Ser 
    850                 855                 860                 


Val Ser Thr Glu Ile Gly Lys Leu Arg Lys Phe Ile Gln Asp Asn Leu 
865                 870                 875                 880 


Asp Lys Leu Thr Glu Val Asn Leu Asp Tyr Asn Phe Leu Asn Asp Tyr 
                885                 890                 895     


Tyr Met Lys Lys Glu Gln Phe Ile Phe Gly Gln Leu Lys Gln Ile Asp 
            900                 905                 910         


Tyr Thr Ile Thr Asn Lys Glu Glu Lys Glu Gln Val Ala Lys Asn Lys 
        915                 920                 925             


Asn Leu Leu Gly Ile Cys Asn Leu Phe Leu Lys Gly Asn Asp Ile Glu 
    930                 935                 940                 


Val Ile Asn Lys Ile Tyr Glu Lys Tyr Glu Ile Leu Lys Lys Ile Ser 
945                 950                 955                 960 


Asp Ser Pro Glu Ile Lys Asn Tyr Asp Glu Ile Ile Pro Asn Gly Ile 
                965                 970                 975     


Lys Leu Asn Glu Ile Arg Tyr Ile Lys Lys Glu Leu Glu Lys Lys Ser 
            980                 985                 990         


Lys Asn Glu Asn Tyr Arg Leu Asn  Ile Asp Arg Ile Lys  Glu Glu Ile 
        995                 1000                 1005             


Gly Lys  Cys Ser Ser Asp Leu  Leu Gly Leu Tyr Lys  Gln Gln Ile 
    1010                 1015                 1020             


Ile Thr  Leu Leu Lys Arg Lys  Ile Ile Glu Lys Ile  Gln Tyr Lys 
    1025                 1030                 1035             


Glu Glu  Lys Val Leu Thr Ile  Leu Thr Tyr Glu Ile  Glu Thr Lys 
    1040                 1045                 1050             


Tyr Lys  Asn Ile Tyr Ser Val  Leu Leu Val Arg Lys  Asn Ser Ser 
    1055                 1060                 1065             


Asn Asn  Phe Ser Phe Leu Glu  Gly Ser Pro Asn Lys  Arg Gln Ile 
    1070                 1075                 1080             


Lys Ile  Gly Asp Lys Thr Thr  Leu Ile Leu Glu Ile  Gly Thr Leu 
    1085                 1090                 1095             


Asp Lys  Asp Lys Asn Arg Glu  Asn Lys Tyr Asn Leu  Tyr Leu Ser 
    1100                 1105                 1110             


Leu Asn  Lys Asn Thr Lys Gly  Lys Lys Val Phe Lys  Arg Glu Val 
    1115                 1120                 1125             


Ile Asp  Leu Arg Gln His Tyr  Leu Phe Thr Glu Glu  Val Lys Phe 
    1130                 1135                 1140             


Lys Asp  Leu Lys 
    1145         


<210>  2781
<211>  1152
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2781

Met Glu Asn Lys Asn Lys Thr Lys Pro Asn Arg Gly Ser Ile Val Arg 
1               5                   10                  15      


Ile Ile Ile Ser Asn Tyr Asp Thr Lys Gly Ile Lys Glu Ile Lys Val 
            20                  25                  30          


Arg Tyr Arg Lys Gln Ala Gln Leu Asp Thr Phe Ile Leu Gln Thr Ala 
        35                  40                  45              


Leu Asp Lys Glu Asn Asn Ser Ile Leu Ile Asn Glu Phe Arg Val Lys 
    50                  55                  60                  


Ala Arg Glu Lys Asn Arg Tyr Ser Phe Thr Tyr Asp Gly Lys Glu Lys 
65                  70                  75                  80  


Phe Ser Ala Pro Ser Asn Ser Val Ile Val Ala Lys Ile Asp Asn Val 
                85                  90                  95      


Ala Pro Glu Lys Phe Lys Glu Ile Arg Lys Tyr Lys Ile Thr Leu Glu 
            100                 105                 110         


Ile Asp Glu Lys Cys Lys Thr Gly Ser Met Ile Thr Ala Ala Ile Glu 
        115                 120                 125             


Asp Leu Leu Glu Asp Asp Ile Ala Arg Glu Gly Ile Arg Asn Pro Arg 
    130                 135                 140                 


Arg Lys Ala Ser Lys Thr Glu Arg Lys Leu Ile Ala Glu Ser Ile Cys 
145                 150                 155                 160 


His Asn Tyr Ala Gln Ile Ala Gln Cys Pro Val Glu Glu Ile Asp Ala 
                165                 170                 175     


Val Lys Ile Tyr Lys Val Lys Arg Phe Leu Ser Tyr Arg Ser Asn Met 
            180                 185                 190         


Leu Leu Phe Phe Ala Leu Ile Asn Asp Phe Leu Cys Lys Asn Leu Lys 
        195                 200                 205             


Asn Glu Lys Gly Glu Lys Ile Arg Glu Ile Trp Arg Ile Glu Asn Lys 
    210                 215                 220                 


Gly Asn Asn Lys Lys Ile Asp Phe Asp Glu Asn Tyr Thr Ile Leu Val 
225                 230                 235                 240 


Ala Gln Ile Lys Glu Tyr Phe Ile Lys Glu Ile Glu Asn Tyr Asn Asn 
                245                 250                 255     


Arg Ile Asp Asn Ile Ile Asp Lys Lys Glu Leu Leu Lys Tyr Ser Glu 
            260                 265                 270         


Glu Lys Glu Glu Ser Glu Lys Asn Lys Lys Leu Lys Glu Leu Asn Lys 
        275                 280                 285             


Leu Glu Ser Gln Lys Leu Lys Ile Leu Thr Asp Glu Glu Ile Lys Ala 
    290                 295                 300                 


Asp Val Ile Lys Ile Ile Lys Ile Phe Ser Asp Leu Arg His Ser Leu 
305                 310                 315                 320 


Met His Tyr Glu Tyr Lys Tyr Phe Glu Asn Leu Phe Glu Asn Lys Lys 
                325                 330                 335     


Asn Glu Glu Leu Ala Glu Leu Leu Asn Leu Asn Leu Phe Lys Asn Leu 
            340                 345                 350         


Thr Leu Leu Arg Gln Met Lys Ile Glu Asn Lys Thr Asn Tyr Leu Glu 
        355                 360                 365             


Gly Asp Glu Lys Phe Asn Ile Leu Gly Lys Asp Val Arg Ala Lys Asn 
    370                 375                 380                 


Ala Leu Gly Tyr Tyr Asn Leu Leu Ala Glu Gln Lys Asn Gly Phe Asn 
385                 390                 395                 400 


Asn Phe Ile Asn Ser Phe Phe Val Gln Asp Gly Thr Glu Asn Leu Glu 
                405                 410                 415     


Phe Lys Lys Leu Ile Asp Glu Asn Phe Ile Lys Ala Gln Lys Glu Leu 
            420                 425                 430         


Glu Glu Asp Ile Lys Asn Cys Lys Glu Ser Val Lys Lys Leu Glu Lys 
        435                 440                 445             


Lys Leu Lys Glu Asn Pro Lys Lys Thr Glu Asp Leu Glu Lys Lys Leu 
    450                 455                 460                 


Glu Lys Lys Gln Lys Lys Leu Lys Glu Leu Lys Lys Glu Leu Glu Lys 
465                 470                 475                 480 


Met Lys Gln His Tyr Lys Arg Leu Asn Cys Ala Tyr Val Trp Asp Ile 
                485                 490                 495     


His Ser Ser Thr Val Tyr Lys Lys Leu Tyr Asn Glu Arg Lys Asn Leu 
            500                 505                 510         


Ile Glu Lys Tyr Asn Lys Gln Leu Asn Gly Leu Gln Asp Lys Asn Ala 
        515                 520                 525             


Ile Thr Gly Ile Asn Ala Gln Leu Leu Arg Ile Lys Lys Glu Met Glu 
    530                 535                 540                 


Glu Ile Thr Lys Ser Asn Ser Leu Phe Arg Leu Lys Tyr Lys Met Gln 
545                 550                 555                 560 


Ile Ala Tyr Ala Phe Leu Glu Met Glu Tyr Glu Gly Asn Ile Ala Lys 
                565                 570                 575     


Phe Lys Asn Glu Phe Asp Cys Ser Lys Thr Glu Lys Ile Gln Glu Trp 
            580                 585                 590         


Leu Glu Lys Asn Glu Glu Tyr Leu Asn Tyr Cys Val Glu Lys Glu Glu 
        595                 600                 605             


Asp Gly Lys Asn Tyr Lys Phe His Phe Lys Glu Ile Ser Glu Ile Lys 
    610                 615                 620                 


Asp Thr His Asn Glu Glu Trp Leu Glu Asn Thr Ser Glu Asn Asn Leu 
625                 630                 635                 640 


Phe Lys Phe Tyr Ile Leu Thr Tyr Leu Leu Leu Pro Met Glu Phe Lys 
                645                 650                 655     


Gly Asp Phe Leu Gly Val Val Lys Lys His Tyr Tyr Asp Ile Lys Asn 
            660                 665                 670         


Val Asp Phe Thr Asp Glu Ser Glu Lys Glu Leu Ser Gln Glu Gln Ile 
        675                 680                 685             


Asp Lys Met Ile Gly Asp Ser Phe Phe His Lys Ile Arg Leu Phe Glu 
    690                 695                 700                 


Lys Asn Thr Lys Arg Tyr Glu Ile Ile Lys Tyr Ser Ile Leu Thr Leu 
705                 710                 715                 720 


Asp Glu Ile Lys Lys Tyr Phe Glu Leu Leu Glu Leu Lys Val Pro Tyr 
                725                 730                 735     


Leu Glu Tyr Lys Gly Ile Asp Glu Ile Gly Ile Phe Asn Lys Asn Ile 
            740                 745                 750         


Ile Leu Pro Ile Phe Lys Tyr Tyr Gln Ile Ile Phe Arg Leu Tyr Asn 
        755                 760                 765             


Asp Leu Glu Ile His Gly Leu Phe Asn Val Ser Ser Asp Ile Asn Lys 
    770                 775                 780                 


Ile Leu Ser Asp Leu Lys Ser Tyr Gly Asn Glu Asn Ile Asn Phe Arg 
785                 790                 795                 800 


Glu Phe Leu Tyr Val Ile Lys Gln Asn Asn Asn Ser Ser Thr Glu Glu 
                805                 810                 815     


Glu Tyr Gln Lys Ile Trp Glu Asn Leu Glu Ala Lys Tyr Leu Lys Lys 
            820                 825                 830         


Ser Leu Leu Thr Gln Glu Lys Lys Glu Ile Lys Thr Lys Thr Lys Glu 
        835                 840                 845             


Glu Leu Glu Lys Leu Asn Glu Thr Ser Phe Leu Arg Asn Lys Ile Ser 
    850                 855                 860                 


His Leu Glu Tyr Asn Lys Ile Ile Glu Glu Ile Leu Lys Thr Glu Ile 
865                 870                 875                 880 


Ser Glu Lys Asn Lys Glu Ala Thr Leu Asn Glu Lys Ile Arg Lys Val 
                885                 890                 895     


Ile Asn Phe Ile Lys Glu Asn Glu Leu Asp Lys Val Glu Leu Gly Phe 
            900                 905                 910         


Asn Phe Ile Asn Asp Phe Phe Met Lys Lys Glu Gln Phe Met Phe Gly 
        915                 920                 925             


Gln Ile Lys Gln Val Lys Glu Ala Asn Ser Asp Ser Ile Thr Thr Glu 
    930                 935                 940                 


Arg Lys Arg Lys Glu Glu Asn Asn Lys Lys Leu Lys Ala Asp Tyr Gly 
945                 950                 955                 960 


Leu Asn Tyr Asn Asn Leu Ser Lys Ile Tyr Glu Ile Ser Asn Thr Leu 
                965                 970                 975     


Arg Glu Ile Val Asn Ser Pro Leu Phe Leu Asn Asp Ser Thr Leu Leu 
            980                 985                 990         


Lys Lys Val Asp Leu Ser Lys Val  Met Leu Lys Glu Lys  Pro Ile Cys 
        995                 1000                 1005             


Ser Leu  Gln Tyr Glu Asn Asn  Thr Lys Leu Glu Asp  Asp Ile Lys 
    1010                 1015                 1020             


Arg Ile  Leu Leu Lys Asp Ser  Ser Asp Ile Met Gly  Ile Tyr Lys 
    1025                 1030                 1035             


Ala Glu  Val Val Lys Lys Leu  Lys Glu Lys Leu Val  Leu Ile Phe 
    1040                 1045                 1050             


Lys Tyr  Asp Glu Glu Lys Arg  Ile Tyr Val Thr Val  Tyr Asp Thr 
    1055                 1060                 1065             


Ser Lys  Ala Val Pro Glu Asn  Ile Ser Lys Glu Ile  Leu Val Lys 
    1070                 1075                 1080             


Arg Asn  Asn Ser Lys Glu Glu  Tyr Phe Phe Glu Asp  Asn Lys Lys 
    1085                 1090                 1095             


Lys Tyr  Thr Thr Gln Tyr Tyr  Thr Leu Glu Ile Thr  Lys Glu Asn 
    1100                 1105                 1110             


Glu Leu  Lys Val Ile Pro Ala  Lys Lys Leu Glu Gly  Lys Glu Phe 
    1115                 1120                 1125             


Lys Thr  Glu Lys Lys Glu Glu  Asn Lys Leu Met Leu  Asn Asn His 
    1130                 1135                 1140             


Tyr Cys  Phe Asn Val Lys Ile  Ile Tyr 
    1145                 1150         


<210>  2782
<211>  1151
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2782

Met Ser Lys Glu Ile Lys Pro Asn Arg Ser Ser Ile Ile Arg Val Ile 
1               5                   10                  15      


Ile Ser Asn Tyr Asp Asn Lys Gly Ile Lys Glu Val Lys Val Arg Tyr 
            20                  25                  30          


Asn Lys Gln Ala Gln Leu Asp Thr Phe Ile Ile Glu Ser Gln Ile Glu 
        35                  40                  45              


Glu Gly Ala Phe Ile Leu Lys Asn Ile Lys Trp Lys Ala Lys Glu Lys 
    50                  55                  60                  


Tyr Arg Tyr Glu Leu Phe Ile Arg Glu Val Asn Ser Thr Ser Val Glu 
65                  70                  75                  80  


Ile Ile Lys Lys Asp Arg Phe Leu Asn Asn Glu Ile Val Arg Gly Tyr 
                85                  90                  95      


Ile Leu Asn Phe Lys Val Ser Ser Lys Asn Lys Asp Val Val Val Val 
            100                 105                 110         


Glu Ile Glu Asp Ile Leu Pro Leu Lys Ser Val Gln Gln Gly Glu Arg 
        115                 120                 125             


Ala Asn Ile Arg Arg Ile Thr Ser Gln Thr Glu Arg Lys Leu Leu Asn 
    130                 135                 140                 


Ile Glu Thr Gln Ile Ser Tyr Ser Lys Ile Ala Ser Cys Ser Pro Glu 
145                 150                 155                 160 


Asp Ile Asp Ser Ile Lys Ile Tyr Lys Ile Lys Arg Tyr Leu Ser Tyr 
                165                 170                 175     


Arg Ser Asn Met Leu Leu Phe Phe Ser Leu Ile Asn Asp Phe Phe Cys 
            180                 185                 190         


Glu Gly Leu Tyr Asp Glu Lys Gly Lys Lys Ile Ser Glu Leu Trp Arg 
        195                 200                 205             


Ile Thr Asn Lys Val Asp Lys Asp Ile Ile Asp Glu Arg Val Asn Lys 
    210                 215                 220                 


Ile Ala Lys Asn Leu Tyr Asn Thr Leu Ser Thr Glu Leu Glu Asn Tyr 
225                 230                 235                 240 


Asn Asn Gly Ile Arg Lys Ser Ile Glu Lys Lys Asn Asn Ser Ile Thr 
                245                 250                 255     


Asp Cys Lys Asn Lys Ile Val Ser Cys Glu Arg Lys Ile Glu Lys Leu 
            260                 265                 270         


Asp Glu Glu Lys Asn Arg Lys Lys Ile Asn Gln Phe Lys Arg Asp Ile 
        275                 280                 285             


Ala Asn Cys Asn Glu Lys Ile Lys Glu Tyr Glu Glu Ser Ile Ala Leu 
    290                 295                 300                 


Lys Glu Lys Glu Lys Leu Phe Asn Leu Gly Phe Glu Lys Ile Lys Ala 
305                 310                 315                 320 


Asp Val Tyr Lys Ile Leu Glu Ile Tyr Thr Glu Leu Arg His Lys Leu 
                325                 330                 335     


Ser His Tyr Asn Tyr Ile Tyr Phe Glu Asn Leu Phe Glu Asn Arg Glu 
            340                 345                 350         


Lys Asp Leu Lys Leu Ala Glu Leu Leu Asn Leu Asn Ile Phe Asn Tyr 
        355                 360                 365             


Leu Thr Leu Ser Lys Lys Leu Arg Ile Glu Asn Lys Thr Asn Tyr Leu 
    370                 375                 380                 


Glu Glu Asp Thr Lys Phe Ser Ile Leu Gly Val Ser Gly Ser Ala Lys 
385                 390                 395                 400 


Lys Tyr Tyr Ser Leu Tyr Asn Thr Leu Cys Glu Gln Lys Asn Gly Phe 
                405                 410                 415     


Asn Asn Phe Ile Asn Ser Phe Phe Val Lys Asp Gly Val Glu Asn Ser 
            420                 425                 430         


Glu Phe Lys Glu Lys Val Glu Ala Lys Leu Lys Glu Asp Ile Lys Tyr 
        435                 440                 445             


Leu Glu Ser Leu Glu Thr Lys Asn Asn Leu Asn Lys Lys Ile His Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Glu Leu Leu Lys Thr Gln Tyr Asn Glu Leu Gly 
465                 470                 475                 480 


Thr Ala Tyr Phe Trp Asp Ile His Ser Ser Ser Asn Tyr Lys Glu Leu 
                485                 490                 495     


Tyr Asn Lys Arg Lys Asp Thr Ile Glu Asn Tyr Asn Gln Ile Leu Lys 
            500                 505                 510         


Gly Asn Arg Asn Lys Thr Thr Leu Arg Asn Tyr Gly Arg Glu Leu Phe 
        515                 520                 525             


Ser Lys Lys Asn Glu Met Glu Lys Ile Thr Lys Arg Asn Ser Ile Val 
    530                 535                 540                 


Arg Leu Lys Tyr Lys Leu Gln Ile Ala Tyr Ala Phe Ile Met Lys Glu 
545                 550                 555                 560 


Phe Glu Gly Asp Ile Ser Arg Phe Lys Ser Asp Phe Asp Ile Ser Lys 
                565                 570                 575     


Ile Glu Gln Ile Lys Lys Tyr Gln Asn Arg Gly Glu Glu Tyr Leu Asn 
            580                 585                 590         


Tyr Cys Asp Gln Asp Asn Phe Lys Ile Lys Asp Phe Gln Lys Met Ile 
        595                 600                 605             


Gly Glu Ile Glu Ser Ser Ser Glu Ile Thr Trp Leu Ser Asn Lys Val 
    610                 615                 620                 


Glu Asn Asn Leu Phe Lys Phe Tyr Val Leu Thr Tyr Ile Leu Leu Pro 
625                 630                 635                 640 


Ile Glu Phe Lys Gly Asp Phe Leu Gly Phe Val Lys Lys His Tyr Tyr 
                645                 650                 655     


Asp Ile Lys Asn Val Glu Tyr Leu Asp Glu Asn Leu Asn Glu Leu Thr 
            660                 665                 670         


Asn Glu Glu Leu Asp Lys Ile Lys Asn Asp Ser Phe Phe Asn Lys Ile 
        675                 680                 685             


Arg Leu Phe Glu Lys Asn Ser Lys Lys Tyr Asn Ile Phe Ser Lys Ser 
    690                 695                 700                 


Ile Leu Thr Gln Glu Arg Val Lys Glu Tyr Phe Arg Arg Leu Glu Ile 
705                 710                 715                 720 


Pro Ala Lys His Tyr Glu Tyr Thr Gly Ser Ser Gly Glu Thr Lys Asn 
                725                 730                 735     


Ile Phe Asn Lys Asn Ile Val Ile Pro Ile Phe Lys Tyr Tyr Glu Ile 
            740                 745                 750         


Val Val Lys Leu Tyr Asn Asp Ile Glu Ile Ala Met Leu Leu Tyr Leu 
        755                 760                 765             


Ser Asn Ile Lys Asn Ile Ser Ile Glu Glu Val Ile Asn Arg Ile Ile 
    770                 775                 780                 


Glu Lys Gln Ser Asn Leu Lys Glu Glu His Lys Glu Phe Tyr Thr Leu 
785                 790                 795                 800 


Thr Glu Leu Phe Gly Phe Phe Lys Leu Val Asn Glu Lys Ala Glu Glu 
                805                 810                 815     


Phe Asp Ser Asn Ile Pro Ile Pro Lys Asn Tyr Leu Asn Ser Lys Pro 
            820                 825                 830         


Ile Ser Leu Arg Asn Asn Ile Phe His Tyr Asn Tyr Glu Gly Phe Ile 
        835                 840                 845             


Gly Gln Leu Leu Asp Ile Asp Ser Glu Gly Ala Ser Asn Phe Ser Val 
    850                 855                 860                 


Asn Ile Glu Ile Arg Lys Leu Leu Lys Phe Ile Asp Pro Tyr Leu Lys 
865                 870                 875                 880 


Lys Leu Lys Ile Leu His Leu Asp Tyr Asn Phe Ile Asn Asp Tyr Tyr 
                885                 890                 895     


Met Lys Lys Glu Gln Phe Met Phe Gly Gln Leu Lys Gln Val Asp Phe 
            900                 905                 910         


Thr Ile Thr Asn Asn Glu Glu Lys Glu Arg Val Ile Lys Asn Lys Arg 
        915                 920                 925             


Leu Leu Glu Ile Cys Lys Leu Lys Leu Glu Lys Asp Asn Ile Glu Asp 
    930                 935                 940                 


Ile Asn Lys Ile Tyr Glu Lys Ser Val Leu Leu Lys Glu Ile Gly Glu 
945                 950                 955                 960 


Thr Leu Lys Val Glu Thr Phe Asn Glu Leu Asp Lys Leu Lys Glu Asn 
                965                 970                 975     


Glu Asn Arg Val Asp Leu Asn Lys Ile Lys Tyr Ile Glu Asp Leu Cys 
            980                 985                 990         


Lys Lys Gln Lys Asn Asn Lys Gln  Lys Ile Asn Met Ser  Lys Val Lys 
        995                 1000                 1005             


Glu Glu  Ile Ile Lys Cys Ser  Ser Asp Val Leu Gly  Leu Tyr Lys 
    1010                 1015                 1020             


Gln Gln  Ile Ile Thr Leu Leu  Lys Asn Lys Ile Ile  Arg Lys Leu 
    1025                 1030                 1035             


Lys Ser  Lys Glu Glu Lys Leu  Leu Thr Ile Ile Thr  Tyr Glu Val 
    1040                 1045                 1050             


Glu Thr  Lys Ala Lys Asn Ile  Tyr Thr Ile Leu Ile  Gly Arg Lys 
    1055                 1060                 1065             


Asn Ser  Ser Asp Ser Phe Tyr  Phe Leu Asn Gly Ser  Pro Asn Lys 
    1070                 1075                 1080             


Gln Gln  Ile Glu Ile Gly Lys  Lys Thr Lys Leu Ile  Leu Glu Ile 
    1085                 1090                 1095             


Gly Ile  Gln Asp Lys Glu Lys  Ile Arg Ile Asn Thr  Ser Asn Leu 
    1100                 1105                 1110             


Tyr Phe  Ser Leu Asn Lys Lys  Ile Lys Asn Glu Asn  Val Phe Ser 
    1115                 1120                 1125             


Lys Lys  Ser Ile Tyr Leu Lys  Lys His Tyr Ser Phe  Leu Val Glu 
    1130                 1135                 1140             


Val Lys  Phe Lys Asp Leu Asn  Lys 
    1145                 1150     


<210>  2783
<211>  1147
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2783

Met Glu Gly Gly Thr Lys Ile Lys Ala Asn Arg Ser Ser Ile Ile Arg 
1               5                   10                  15      


Ile Ile Ile Ser Asn Tyr Asp Ser Asn Gly Ile Lys Glu Ile Lys Val 
            20                  25                  30          


Arg Tyr Asn Lys Gln Ala Gln Leu Asp Thr Phe Leu Ile Glu Ser Lys 
        35                  40                  45              


Leu Glu Asn Gly Val Phe Thr Leu Lys Asn Val Glu Trp Lys Ala Lys 
    50                  55                  60                  


Glu Lys Asn Arg Tyr Asn Ile Ile Arg Glu Glu Ile Ile Asp Asn Ser 
65                  70                  75                  80  


Val Lys Ile Thr Lys Ile Asp Lys Phe Ser Asn Glu Ala Ile Arg Gly 
                85                  90                  95      


Tyr Ile Ile Lys Phe Ser Val Ser Pro Lys Asn Lys Asn Val Val Val 
            100                 105                 110         


Val Asp Ile Lys Asp Cys Met Glu His Asn Leu Thr Ile Lys Glu Glu 
        115                 120                 125             


Arg Ser Asn Thr Arg Arg Asp Thr Ser Arg Thr Glu Arg Lys Leu Leu 
    130                 135                 140                 


Ser Lys Glu Thr Gln Ile Thr Tyr Ser Lys Ile Ala Cys Cys Pro Leu 
145                 150                 155                 160 


Glu Asn Ile Asp Ser Leu Lys Ile Tyr Lys Ile Lys Arg Tyr Leu Ser 
                165                 170                 175     


Tyr Arg Ser Asn Met Leu Leu Phe Phe Ser Leu Ile Asn Asp Phe Ile 
            180                 185                 190         


Cys Glu Gly Ile Lys Glu Glu Lys Ile Val Glu Leu Tyr Lys Ile Thr 
        195                 200                 205             


Ser Lys Val Asp Glu Asn Ile Leu Glu Glu Arg Val Thr Lys Ile Ala 
    210                 215                 220                 


Gln Tyr Leu Arg Glu Asn Leu Ser Asn Glu Leu Lys Asn Tyr Asn Asn 
225                 230                 235                 240 


Gly Ile Glu Lys Thr Ile Ser Lys Lys Asn Asn Ser Ile Asn Asp Cys 
                245                 250                 255     


Asn Asn Arg Ile Glu Ser Cys Lys Lys Lys Ile Lys Lys Leu Asp Lys 
            260                 265                 270         


Ile Lys Asp Lys Lys Gln Ile Arg Asn Leu Glu Arg Ile Ile Gln Asp 
        275                 280                 285             


Ser Glu Asn Lys Ile Lys Glu Tyr Ser Lys Ile Ile Ala Glu Lys Glu 
    290                 295                 300                 


Lys Glu Arg Leu Val Ala Leu Ala Glu Asp Lys Ile Lys Glu Asp Val 
305                 310                 315                 320 


Tyr Lys Ile Leu Glu Leu Tyr Ser Asp Leu Arg His Lys Leu Ala His 
                325                 330                 335     


Tyr Asn Tyr Ala Tyr Phe Glu Asn Leu Phe Glu Asn Asn Ile Glu Asp 
            340                 345                 350         


Ser Asn Met Val Asn Met Ala Lys Leu Leu Asp Leu Asn Ile Phe Lys 
        355                 360                 365             


Tyr Leu Glu Leu Ser Lys Lys Leu Arg Ile Glu Asn Lys Thr Asn Tyr 
    370                 375                 380                 


Leu Asp Asp Asp Thr Lys Phe Ser Ile Leu Gly Val Arg Gly Lys Ala 
385                 390                 395                 400 


Lys Lys Tyr Tyr Ser Leu Tyr Asn Thr Leu Cys Glu Gln Lys Asn Gly 
                405                 410                 415     


Phe Asn Thr Phe Ile Asn Asn Phe Phe Thr Lys Asp Gly Ile Glu Asp 
            420                 425                 430         


Ile Asp Phe Lys Asp Lys Val Asn Ala Arg Phe Lys Glu Glu Ile Lys 
        435                 440                 445             


Glu Leu Glu Glu Phe Glu Thr Lys Gln Lys Glu Lys Lys Lys Lys Phe 
    450                 455                 460                 


Lys Asp Lys Glu Leu Glu Leu Leu Lys Lys Gln Asp Thr Glu Leu Lys 
465                 470                 475                 480 


Thr Ala Tyr Ile Trp Asp Ile His Asn Ser Ile Asp Tyr Lys Lys Phe 
                485                 490                 495     


Tyr Ser Arg Arg Lys Asp Ile Val Glu Lys Tyr Asn Gln Thr Leu Ser 
            500                 505                 510         


Gly Asn Arg Asn Lys Ile Ala Leu Arg Asp Tyr Gly Ala Lys Leu Leu 
        515                 520                 525             


Glu Ile Lys Asn Lys Met Asp Asn Ile Thr Lys Arg Asn Ser Ile Ile 
    530                 535                 540                 


Arg Leu Lys Tyr Lys Leu Gln Val Ala Tyr Ala Phe Leu Met Lys Glu 
545                 550                 555                 560 


Phe Asn Gly Asn Ile Ala Arg Phe Lys Ser Glu Phe Asp Val Ser Lys 
                565                 570                 575     


Val Glu Gln Val Glu Lys Tyr Gln Ala Arg Arg Glu Glu Tyr Leu Tyr 
            580                 585                 590         


Tyr Ile Asp Lys Lys Asn Phe Lys Ile Glu Lys Phe Gln Glu Ile Leu 
        595                 600                 605             


Gly Glu Leu Glu Ala Ser Asn Lys Val Thr Trp Leu Ser Ser Asp Thr 
    610                 615                 620                 


Glu Asn Asn Leu Phe Lys Phe Tyr Val Leu Thr Tyr Ile Leu Leu Pro 
625                 630                 635                 640 


Phe Glu Phe Lys Gly Asp Phe Leu Gly Phe Val Lys Lys His Tyr Tyr 
                645                 650                 655     


Asp Ile Lys Asn Val Glu Tyr Leu Asp Glu Asn Asn Asp Glu Leu Thr 
            660                 665                 670         


Asn Glu Gln Leu Glu Lys Met Lys Asp Asp Ser Phe Phe Asn Lys Ile 
        675                 680                 685             


Arg Leu Phe Glu Lys Asn Ser Lys Lys Tyr Asn Ile Phe Ser Lys Ser 
    690                 695                 700                 


Phe Leu Thr Asn Glu Arg Val Lys Glu Tyr Phe Glu Lys Leu Asn Ile 
705                 710                 715                 720 


Gly Ala Lys His Tyr Glu Tyr Val Gly Ala Asn Gly Glu Thr Lys Gly 
                725                 730                 735     


Ile Phe Asn Lys Asn Ile Ile Ile Pro Ile Phe Lys Tyr Tyr Gln Ile 
            740                 745                 750         


Ile Ile Lys Leu Tyr Asn Asp Val Glu Ile Ala Ile Leu Leu Tyr Leu 
        755                 760                 765             


Ser Lys Leu Lys Gly Asp Ile Pro Ile Asp Glu Val Ile Asp Lys Val 
    770                 775                 780                 


Thr Gln Lys Gln Ser Ile Thr Lys Gly Arg Glu Leu Asp Phe Tyr Ser 
785                 790                 795                 800 


Leu Asn Gly Leu Phe Val Phe Phe Lys Leu Ile Asn Asp Asn Leu Ala 
                805                 810                 815     


Glu Phe Asp Thr Thr Glu Lys Ile Pro Lys Asp Tyr Leu Lys Ser Glu 
            820                 825                 830         


Val Thr Phe Ile Arg Asn Lys Val Phe His Phe Asp Tyr Lys Asn Phe 
        835                 840                 845             


Ile Asp Asn Leu Leu Glu Ile Ala Cys Glu Asn Gly Ser Lys Phe Ser 
    850                 855                 860                 


Val Ser Thr Glu Ile Gly Lys Leu Arg Lys Phe Ile Gln Asp Asn Leu 
865                 870                 875                 880 


Asp Lys Leu Thr Glu Val Asn Leu Asp Tyr Asn Phe Leu Asn Asp Tyr 
                885                 890                 895     


Tyr Met Lys Lys Glu Gln Phe Ile Phe Gly Gln Leu Lys Gln Ile Asp 
            900                 905                 910         


Tyr Thr Ile Thr Asn Lys Glu Glu Lys Glu Gln Val Ala Lys Asn Lys 
        915                 920                 925             


Asn Leu Leu Gly Ile Cys Asn Leu Phe Leu Lys Gly Asn Asp Ile Glu 
    930                 935                 940                 


Val Ile Asn Lys Ile Phe Glu Lys Tyr Glu Ile Leu Lys Lys Ile Ser 
945                 950                 955                 960 


Asp Ser Pro Glu Ile Lys Asn Tyr Asp Glu Ile Ile Pro Asn Gly Ile 
                965                 970                 975     


Lys Leu Asn Glu Ile Arg Tyr Ile Lys Lys Glu Leu Glu Lys Lys Ser 
            980                 985                 990         


Lys Asn Glu Asn Tyr Arg Leu Asn  Ile Asp Arg Ile Lys  Glu Glu Ile 
        995                 1000                 1005             


Gly Lys  Cys Ser Ser Asp Leu  Leu Gly Leu Tyr Lys  Gln Gln Ile 
    1010                 1015                 1020             


Ile Thr  Leu Leu Lys Arg Lys  Ile Ile Glu Lys Ile  Gln Tyr Lys 
    1025                 1030                 1035             


Glu Glu  Lys Val Leu Thr Ile  Leu Thr Tyr Glu Ile  Glu Thr Lys 
    1040                 1045                 1050             


Tyr Lys  Asn Ile Tyr Thr Ile  Leu Leu Val Arg Lys  Asn Ser Ser 
    1055                 1060                 1065             


Asn Asn  Phe Ser Phe Leu Glu  Gly Ser Pro Asn Lys  Arg Gln Ile 
    1070                 1075                 1080             


Lys Ile  Gly Asp Lys Thr Thr  Leu Ile Leu Glu Ile  Gly Thr Leu 
    1085                 1090                 1095             


Asp Lys  Asp Lys Asn Arg Glu  Asn Lys Tyr Asn Leu  Tyr Leu Ser 
    1100                 1105                 1110             


Leu Asn  Lys Asn Thr Lys Gly  Lys Lys Val Phe Lys  Arg Lys Val 
    1115                 1120                 1125             


Ile Asp  Leu Arg Gln His Tyr  Leu Phe Thr Glu Glu  Val Lys Phe 
    1130                 1135                 1140             


Lys Asp  Leu Lys 
    1145         


<210>  2784
<211>  1147
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2784

Met Glu Gly Gly Thr Lys Ile Lys Ala Asn Arg Ser Ser Ile Ile Arg 
1               5                   10                  15      


Ile Ile Ile Ser Asn Tyr Asp Ser Asn Gly Ile Lys Glu Ile Lys Val 
            20                  25                  30          


Arg Tyr Asn Lys Gln Ala Gln Leu Asp Thr Phe Leu Ile Glu Ser Lys 
        35                  40                  45              


Leu Glu Asn Gly Val Phe Thr Leu Lys Asn Val Glu Trp Lys Ala Lys 
    50                  55                  60                  


Glu Lys Asn Arg Tyr Asn Ile Ile Arg Gly Glu Ile Ile Asp Asn Ser 
65                  70                  75                  80  


Val Lys Ile Thr Lys Ile Asp Lys Leu Ser Asn Lys Ala Ile Arg Glu 
                85                  90                  95      


Tyr Ile Ile Lys Phe Ser Val Ser Pro Lys Asn Lys Asn Val Val Val 
            100                 105                 110         


Val Asp Ile Lys Asp Cys Met Glu His Asn Leu Thr Ile Lys Gly Glu 
        115                 120                 125             


Arg Ser Asn Thr Arg Arg Asp Thr Ser Gln Thr Glu Arg Lys Leu Leu 
    130                 135                 140                 


Ser Lys Glu Thr Gln Ile Thr Tyr Ser Lys Ile Ala Cys Cys Pro Pro 
145                 150                 155                 160 


Glu Asn Ile Asp Ser Leu Lys Ile Tyr Lys Ile Lys Arg Tyr Leu Ser 
                165                 170                 175     


Tyr Arg Ser Asn Met Leu Leu Phe Phe Ser Leu Ile Asn Asp Phe Ile 
            180                 185                 190         


Cys Glu Gly Ile Lys Glu Glu Lys Ile Val Glu Leu Tyr Lys Ile Thr 
        195                 200                 205             


Ser Lys Val Asp Lys Asn Ile Ile Glu Glu Arg Val Thr Lys Ile Ala 
    210                 215                 220                 


Gln Tyr Leu Arg Glu Asn Leu Ser Asn Glu Leu Lys Asn Tyr Asn Asn 
225                 230                 235                 240 


Gly Ile Glu Lys Thr Ile Ser Lys Lys Ser Asn Ser Ile Asn Asp Cys 
                245                 250                 255     


Asn Asn Arg Ile Glu Ser Cys Lys Lys Lys Ile Lys Lys Leu Asp Lys 
            260                 265                 270         


Ile Lys Asp Lys Lys Gln Ile Arg Asn Leu Glu Arg Ile Ile Gln Asp 
        275                 280                 285             


Ser Glu Asn Lys Ile Lys Glu Tyr Ser Lys Ile Ile Ala Glu Lys Glu 
    290                 295                 300                 


Lys Glu Arg Leu Val Ala Leu Ala Glu Asn Lys Ile Lys Glu Asp Val 
305                 310                 315                 320 


Tyr Lys Ile Leu Glu Leu Tyr Ser Asp Leu Arg His Lys Leu Ala His 
                325                 330                 335     


Tyr Asn Tyr Ala Tyr Phe Glu Asn Leu Phe Glu Asn Asn Val Glu Asp 
            340                 345                 350         


Ser Asn Met Val Asn Met Ala Lys Leu Leu Asp Leu Asn Ile Phe Lys 
        355                 360                 365             


Tyr Leu Glu Leu Ser Lys Lys Leu Arg Ile Glu Asn Lys Thr Asn Tyr 
    370                 375                 380                 


Leu Asp Asp Asp Thr Lys Phe Ser Ile Leu Gly Val Arg Gly Lys Ala 
385                 390                 395                 400 


Lys Lys Tyr Tyr Ser Leu Tyr Asn Thr Leu Cys Glu Gln Lys Asn Gly 
                405                 410                 415     


Phe Asn Thr Phe Ile Asn Asn Phe Phe Thr Lys Asp Gly Ile Glu Asp 
            420                 425                 430         


Ile Asp Phe Lys Asn Lys Val Asn Thr Arg Phe Lys Glu Glu Ile Lys 
        435                 440                 445             


Glu Leu Glu Glu Phe Glu Ala Lys Gln Lys Glu Lys Lys Lys Asn Phe 
    450                 455                 460                 


Lys Asp Lys Glu Leu Lys Leu Leu Lys Glu Gln Asp Thr Glu Leu Glu 
465                 470                 475                 480 


Thr Ala Tyr Val Trp Asp Ile His Asn Ser Ile Asp Tyr Lys Lys Phe 
                485                 490                 495     


Tyr Ser Arg Arg Lys Asp Ile Val Glu Lys Tyr Asn Gln Thr Leu Ser 
            500                 505                 510         


Gly Asn Arg Asp Lys Thr Ala Leu Arg Asp Cys Gly Thr Lys Leu Leu 
        515                 520                 525             


Asp Ile Lys Asn Lys Met Asp Asn Ile Thr Lys Arg Asn Ser Ile Ile 
    530                 535                 540                 


Arg Leu Lys Tyr Lys Leu Gln Val Ala Tyr Ala Phe Leu Met Lys Glu 
545                 550                 555                 560 


Phe Asn Gly Asn Ile Ala Arg Phe Lys Ser Glu Phe Asp Val Ser Lys 
                565                 570                 575     


Val Glu Gln Val Glu Lys Tyr Gln Ala His Arg Glu Glu Tyr Leu Tyr 
            580                 585                 590         


Tyr Val Asp Lys Glu Asn Phe Lys Ile Glu Lys Phe Gln Glu Ile Leu 
        595                 600                 605             


Gly Glu Leu Glu Ala Ser Asn Lys Val Thr Trp Leu Ser Ser Asp Thr 
    610                 615                 620                 


Glu Asn Asn Leu Phe Lys Phe Tyr Val Leu Thr Tyr Ile Leu Leu Pro 
625                 630                 635                 640 


Phe Glu Phe Lys Gly Asp Phe Leu Gly Phe Val Lys Lys His Tyr Tyr 
                645                 650                 655     


Asp Ile Lys Asn Val Glu Tyr Leu Asp Glu Asn Asn Glu Glu Leu Thr 
            660                 665                 670         


Asn Glu Gln Leu Glu Lys Met Lys Asp Asp Ser Phe Phe Asn Lys Ile 
        675                 680                 685             


Arg Leu Phe Glu Lys Asn Ser Lys Lys Tyr Asn Ile Phe Ser Lys Ser 
    690                 695                 700                 


Phe Leu Thr Asn Glu Arg Val Lys Glu Tyr Phe Glu Lys Leu Asn Ile 
705                 710                 715                 720 


Gly Ala Lys His Tyr Glu Tyr Val Gly Ala Asn Gly Glu Thr Lys Gly 
                725                 730                 735     


Ile Phe Asn Lys Asn Ile Thr Ile Pro Ile Phe Lys Tyr Tyr Gln Ile 
            740                 745                 750         


Ile Ile Lys Leu Tyr Asn Asp Val Glu Ile Ala Ile Leu Leu Tyr Leu 
        755                 760                 765             


Ser Lys Leu Lys Gly Asp Ile Pro Ile Asp Glu Val Ile Asp Lys Val 
    770                 775                 780                 


Thr Gln Lys Gln Ser Ile Thr Glu Gly Lys Glu Leu Asp Phe Tyr Ser 
785                 790                 795                 800 


Leu Asn Gly Leu Phe Gly Phe Phe Glu Leu Ile Asn Asp Asn Leu Ala 
                805                 810                 815     


Glu Phe Gly Thr Thr Glu Lys Ile Pro Lys Ser Tyr Leu Glu Ser Lys 
            820                 825                 830         


Ala Thr Phe Ile Arg Asn Lys Val Phe His Phe Glu Tyr Glu Asn Phe 
        835                 840                 845             


Ile Asp Asn Leu Leu Glu Ile Asp Cys Glu Asn Gly Ser Lys Phe Ser 
    850                 855                 860                 


Val Ser Thr Glu Met Gly Lys Leu Arg Lys Phe Ile Gln Asn Asn Leu 
865                 870                 875                 880 


Asp Lys Leu Thr Gly Ile Asn Leu Asp Tyr Asn Phe Leu Asn Asp Tyr 
                885                 890                 895     


Tyr Met Lys Lys Glu Gln Phe Ile Phe Gly Gln Leu Lys Gln Ile Asp 
            900                 905                 910         


Tyr Thr Ile Thr Asn Lys Glu Glu Lys Glu Gln Val Ala Lys Asn Lys 
        915                 920                 925             


Asn Leu Leu Gly Ile Cys Asn Leu Phe Leu Lys Gly Asn Asp Ile Glu 
    930                 935                 940                 


Val Val Asn Lys Ile Tyr Glu Lys Tyr Glu Ile Leu Lys Lys Ile Ser 
945                 950                 955                 960 


Asp Ser Pro Glu Ile Lys Asn Tyr Asp Glu Ile Ile Pro Asn Gly Ile 
                965                 970                 975     


Lys Leu Asn Glu Ile Arg Tyr Ile Lys Lys Glu Leu Glu Lys Lys Ser 
            980                 985                 990         


Lys Asn Glu Asn Tyr Arg Leu Asn  Ile Asp Arg Ile Lys  Glu Glu Ile 
        995                 1000                 1005             


Gly Lys  Cys Ser Ser Asp Leu  Leu Gly Leu Tyr Lys  Gln Gln Ile 
    1010                 1015                 1020             


Ile Thr  Leu Leu Lys Arg Lys  Ile Ile Glu Lys Ile  Gln Tyr Lys 
    1025                 1030                 1035             


Glu Glu  Lys Ile Leu Thr Ile  Phe Thr Tyr Glu Ile  Glu Thr Lys 
    1040                 1045                 1050             


His Lys  Lys Thr Tyr Thr Ile  Leu Leu Ala Arg Lys  Asn Ser Ser 
    1055                 1060                 1065             


Asp Asn  Phe Tyr Phe Leu Glu  Arg Ser Pro Asn Gln  Lys Gln Ile 
    1070                 1075                 1080             


Asn Ile  Gly Asp Lys Thr Ile  Leu Lys Leu Glu Ile  Gly Thr Leu 
    1085                 1090                 1095             


Asp Lys  Asp Lys Asn Arg Glu  Asn Lys Tyr Asn Leu  Tyr Leu Ser 
    1100                 1105                 1110             


Leu Asn  Lys Asn Ala Lys Gly  Lys Lys Val Phe Lys  Arg Glu Val 
    1115                 1120                 1125             


Ile Asp  Leu Arg Gln His Tyr  Leu Phe Thr Glu Glu  Ile Lys Phe 
    1130                 1135                 1140             


Lys Asp  Leu Lys 
    1145         


<210>  2785
<211>  992
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2785

Met Leu Leu Phe Phe Ser Leu Ile Asn Asp Phe Leu Cys Glu Gly Leu 
1               5                   10                  15      


Tyr Asp Glu Lys Gly Lys Lys Ile Asn Glu Leu Trp Arg Ile Thr Asn 
            20                  25                  30          


Lys Val Asp Lys Asp Ile Ile Asp Glu Arg Val Asn Lys Ile Ala Lys 
        35                  40                  45              


Asn Leu Tyr Asn Thr Leu Ser Thr Glu Leu Glu Asn Tyr Asn Asn Gly 
    50                  55                  60                  


Ile Arg Lys Ser Ile Glu Lys Lys Asn Asn Ser Ile Thr Asp Cys Lys 
65                  70                  75                  80  


Asn Lys Ile Val Ser Cys Glu Arg Lys Ile Glu Lys Leu Asp Glu Glu 
                85                  90                  95      


Lys Asn Arg Lys Lys Ile Asn Gln Phe Lys Arg Asp Ile Ala Asn Cys 
            100                 105                 110         


Asn Glu Lys Ile Lys Glu Tyr Glu Glu Ser Ile Ala Leu Lys Glu Lys 
        115                 120                 125             


Glu Lys Leu Phe Asn Leu Gly Phe Lys Lys Ile Lys Ala Asp Val Tyr 
    130                 135                 140                 


Lys Ile Leu Glu Ile Tyr Thr Glu Leu Arg His Lys Leu Ser His Tyr 
145                 150                 155                 160 


Asn Tyr Ile Tyr Phe Glu Asn Leu Phe Glu Asn Arg Glu Glu Asp Leu 
                165                 170                 175     


Lys Leu Val Glu Leu Leu Asn Leu Asn Ile Phe Asn Tyr Leu Thr Leu 
            180                 185                 190         


Ser Lys Lys Leu Arg Ile Glu Asn Lys Thr Asn Tyr Leu Glu Glu Asp 
        195                 200                 205             


Thr Lys Phe Ser Ile Leu Gly Val Ser Gly Leu Ala Lys Lys Tyr Tyr 
    210                 215                 220                 


Ser Leu Tyr Asn Thr Leu Cys Glu Gln Lys Asn Gly Phe Asn Asn Phe 
225                 230                 235                 240 


Ile Asn Ser Phe Phe Val Lys Asp Gly Val Glu Asn Ser Glu Phe Lys 
                245                 250                 255     


Glu Lys Val Glu Ala Lys Leu Lys Glu Asp Ile Lys Tyr Leu Glu Ser 
            260                 265                 270         


Leu Glu Thr Lys Asn Asn Leu Asn Lys Lys Ile Pro Arg Lys Asn Lys 
        275                 280                 285             


Glu Leu Glu Leu Leu Lys Thr Gln Tyr Ser Glu Leu Gly Ile Val Tyr 
    290                 295                 300                 


Phe Trp Asp Ile His Ser Ser Ser Asn Tyr Lys Glu Leu Tyr Asn Lys 
305                 310                 315                 320 


Arg Lys Asp Thr Ile Glu Asn Tyr Asn Gln Ile Leu Lys Gly Asn Arg 
                325                 330                 335     


Asn Lys Thr Thr Leu Arg Asn Tyr Gly Arg Glu Leu Phe Ser Lys Lys 
            340                 345                 350         


Asn Glu Met Glu Lys Ile Thr Lys Arg Asn Ser Ile Val Arg Leu Lys 
        355                 360                 365             


Tyr Lys Leu Gln Ile Ala Tyr Ala Phe Ile Met Lys Glu Phe Glu Gly 
    370                 375                 380                 


Asp Ile Ser Arg Phe Lys Ser Asp Phe Asp Ile Ser Lys Ile Glu Gln 
385                 390                 395                 400 


Ile Lys Lys Tyr Gln Asn Arg Gly Glu Glu Tyr Leu Asn Tyr Cys Asp 
                405                 410                 415     


Gln Asp Asn Phe Lys Ile Lys Asp Phe Gln Lys Met Ile Gly Glu Ile 
            420                 425                 430         


Glu Ser Ser Ser Glu Ile Thr Trp Leu Ser Asn Lys Val Glu Asn Asn 
        435                 440                 445             


Leu Phe Lys Phe Tyr Val Leu Thr Tyr Ile Leu Leu Pro Ile Glu Phe 
    450                 455                 460                 


Lys Gly Asp Phe Leu Gly Phe Val Lys Lys His Tyr Tyr Asp Ile Lys 
465                 470                 475                 480 


Asn Val Glu Tyr Leu Asp Glu Asn Leu Asn Glu Leu Thr Asn Glu Glu 
                485                 490                 495     


Leu Asp Lys Ile Lys Asn Asp Ser Phe Phe Asn Lys Ile Arg Leu Phe 
            500                 505                 510         


Glu Lys Asn Ser Lys Lys Tyr Asn Ile Phe Ser Lys Ser Ile Leu Thr 
        515                 520                 525             


Gln Glu Arg Val Lys Glu Tyr Phe Arg Arg Leu Glu Ile Pro Ala Lys 
    530                 535                 540                 


His Tyr Glu Tyr Thr Gly Asn Ser Gly Glu Thr Lys Asn Ile Phe Asn 
545                 550                 555                 560 


Lys Asn Ile Val Ile Pro Ile Phe Lys Tyr Tyr Glu Ile Val Val Lys 
                565                 570                 575     


Leu Tyr Asn Asp Ile Glu Ile Ala Met Leu Leu Tyr Leu Ser Asn Ile 
            580                 585                 590         


Lys Asn Ile Ser Ile Glu Glu Val Ile Asn Arg Ile Ile Glu Lys Gln 
        595                 600                 605             


Asn Asn Leu Lys Glu Glu His Lys Glu Phe Tyr Thr Leu Thr Glu Leu 
    610                 615                 620                 


Phe Gly Phe Phe Lys Leu Val Asn Glu Lys Ala Glu Glu Phe Asp Ser 
625                 630                 635                 640 


Asn Ile Ser Ile Pro Glu Lys Tyr Leu Asn Ser Lys Pro Ile Ser Leu 
                645                 650                 655     


Arg Asn Asn Ile Phe His Tyr Asn Tyr Glu Gly Phe Ile Gly Gln Leu 
            660                 665                 670         


Leu Asp Ile Asn Ser Glu Gly Ala Ser Asn Phe Ser Val Asn Ile Glu 
        675                 680                 685             


Ile Arg Lys Leu Leu Lys Phe Ile Asp Pro Tyr Leu Lys Lys Leu Lys 
    690                 695                 700                 


Ile Leu His Leu Asp Tyr Asn Phe Ile Asn Asp Tyr Tyr Met Lys Lys 
705                 710                 715                 720 


Glu Gln Phe Met Phe Gly Gln Leu Lys Gln Val Asp Phe Thr Ile Thr 
                725                 730                 735     


Asn Asn Glu Glu Lys Glu Arg Val Ile Lys Asn Lys Arg Leu Leu Glu 
            740                 745                 750         


Ile Cys Lys Leu Lys Leu Glu Lys Asp Asn Ile Glu Asp Ile Asn Lys 
        755                 760                 765             


Ile Tyr Glu Lys Ser Val Leu Leu Lys Glu Ile Gly Glu Thr Leu Lys 
    770                 775                 780                 


Val Glu Thr Phe Asn Glu Leu Asn Ser Leu Lys Glu Asn Arg Val Asn 
785                 790                 795                 800 


Leu Asn Lys Ile Lys Tyr Ile Glu Asp Leu Cys Lys Lys Gln Lys Lys 
                805                 810                 815     


Asn Glu Gln Lys Ile Asn Val Asn Lys Val Lys Glu Glu Ile Ile Lys 
            820                 825                 830         


Cys Ser Ser Asp Val Leu Gly Leu Tyr Lys Gln Gln Ile Ile Thr Leu 
        835                 840                 845             


Leu Lys Asn Lys Ile Ile Arg Lys Leu Lys Tyr Lys Glu Glu Lys Leu 
    850                 855                 860                 


Leu Thr Ile Ile Thr Tyr Glu Val Glu Thr Lys Ala Lys Asn Ile Tyr 
865                 870                 875                 880 


Thr Ile Leu Ile Glu Arg Lys Asn Ser Ser Asn Asn Phe Tyr Phe Leu 
                885                 890                 895     


Asn Asp Phe Arg Asn Lys Gln Gln Ser Ile Asn Gly Glu Lys Ile Ile 
            900                 905                 910         


Glu Lys Asn Ile Thr Ile Lys Gly Gly His Ser Gln Gln Arg Leu Asn 
        915                 920                 925             


Ile Gly Asp Lys Thr Thr Leu Ile Leu Glu Ile Gly Arg Glu Asp Glu 
    930                 935                 940                 


Glu Lys Asn Arg Ile Asp Ser Phe Asn Leu Tyr Phe Ser Leu Asn Lys 
945                 950                 955                 960 


Lys Lys Val Glu Glu Lys Ile Phe Lys Lys Glu Ser Leu Asp Leu Arg 
                965                 970                 975     


Glu His Tyr Ser Phe Leu Ala Glu Val Lys Phe Lys Asp Leu Asn Lys 
            980                 985                 990         


<210>  2786
<211>  1035
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2786

Met Thr Asn Asn Lys Lys Pro Ala Asn Lys Asn Ser Ile Ile Arg Val 
1               5                   10                  15      


Ile Ile Ser Asn Phe Asp Glu Asn Ser Ile Lys Glu Ile Lys Val Leu 
            20                  25                  30          


Tyr Thr Lys Gln Gly Gly Val Asp Thr Ile His Ile Lys Lys Met Ser 
        35                  40                  45              


Met Cys Glu Glu Asp Lys Ser Leu Tyr Phe Glu Glu Val Glu Cys Asn 
    50                  55                  60                  


Ser Gln Phe Gly Asn Ile Asp Ile Lys Ile Glu Lys Asp Asn Arg Ser 
65                  70                  75                  80  


Val Ile Val Glu Lys Tyr Asp Lys Tyr Thr Gly Leu Ile Ile Arg Lys 
                85                  90                  95      


Tyr Lys Ile Phe Gly Thr Tyr Val Ile Thr Asn Lys Asn Ile Lys Leu 
            100                 105                 110         


Val Lys Val Tyr Val Gln Asp Ile Leu Asn Glu Lys Ser Thr Asn Lys 
        115                 120                 125             


Arg Arg Ile Glu Ser Tyr Thr Glu Arg Leu Leu Ile Asp Pro Ala Val 
    130                 135                 140                 


Ile Asn Asp Tyr Lys Lys Ile Met Glu Asn Asn Gln Asp Ile Asp Ser 
145                 150                 155                 160 


Lys Asn Ile Tyr Lys Leu Asn Arg Phe Ile Asn Tyr Arg Ser Asn Met 
                165                 170                 175     


Met Leu Tyr Phe Thr Phe Val Tyr Arg Phe Leu Gly Met Glu Leu Gly 
            180                 185                 190         


Thr Asn Gly Glu Val Tyr Lys Leu Asp Gln Glu Cys Asn Leu Glu Lys 
        195                 200                 205             


Gln Lys Lys Val Val Asp Tyr Val Ala Ser Asn Ile Glu Lys Phe Val 
    210                 215                 220                 


Glu Asn His Asn Asn Tyr Ala Gln Lys Arg Asn Glu Glu Thr Glu Glu 
225                 230                 235                 240 


Lys Lys Leu His Arg Asp Lys Glu Ile Leu Ile Glu Ile Asp Lys Lys 
                245                 250                 255     


Leu Leu Glu Lys Asp Ile Lys Asn Ile Ile Thr Ile Val Ala Ser Val 
            260                 265                 270         


Arg His Lys Leu Ala His Tyr Asn Tyr Thr Phe Phe Gln Asp Leu Leu 
        275                 280                 285             


Glu Gly Lys Glu Ile Val Leu Glu Lys Gln Lys Pro Leu Asn Glu Leu 
    290                 295                 300                 


Leu Asp Leu Asn Ile Phe Lys Glu Ile Gly Lys Ile Lys Asn Leu Lys 
305                 310                 315                 320 


Glu Glu Lys Ala Thr Thr Tyr Leu Glu Asp Asp Thr Lys Val Tyr Val 
                325                 330                 335     


Leu Gly Lys His Lys Lys Ala Lys Lys Leu Tyr Asn Tyr Tyr Asp Lys 
            340                 345                 350         


Leu Cys Thr Arg Lys Asp Gly Phe Asn Asn Phe Ile Asn Ser Phe Phe 
        355                 360                 365             


Ser Val Asp Gly Asn Glu Asn Pro Asp Phe Lys Lys His Ile Asn Glu 
    370                 375                 380                 


His Phe Glu Lys Arg Ile Asp Glu Leu Asn Tyr Gln Val Asn Asn Thr 
385                 390                 395                 400 


Lys Lys Val Arg Glu Asp Ile Lys Arg Glu Leu Val Glu Met Gln Glu 
                405                 410                 415     


Ile Lys Lys Leu Ile Gly Glu Ala Tyr Ile Trp Asp Ile His Gln Cys 
            420                 425                 430         


Lys Glu Tyr Lys Arg Ile Tyr Asn Lys Arg Lys Asn Leu Val Glu Glu 
        435                 440                 445             


Val Ser Gln Leu Ser Arg Lys Ala Asn Arg Asp Lys Val Asp Lys Asp 
    450                 455                 460                 


Lys Ile Ser Lys Leu Asn Asn Glu Ile Leu Lys Met Asn Thr Gln Met 
465                 470                 475                 480 


Glu Lys Tyr Thr Lys Leu Asn Ser Lys Phe Arg Leu Gln Tyr Lys Leu 
                485                 490                 495     


Gln Met Ala Tyr Gly Phe Leu Tyr Glu Glu Tyr Gly Phe Asp Leu Lys 
            500                 505                 510         


Arg Phe Gly Asp Arg Phe Asn Ser Ser Ile Leu Asp Glu Leu Lys Pro 
        515                 520                 525             


Tyr Lys Glu Asn Gly Leu Lys Tyr Leu Lys Thr Lys Val Thr Ser Asn 
    530                 535                 540                 


Asp Asn Ile Gly Phe Ser Leu Gly Glu Phe Glu Lys Lys Ile Asn Ala 
545                 550                 555                 560 


Met Lys Ala Met Asp Asn Gly Leu Phe Asn Pro Thr His Ser Asn Asn 
                565                 570                 575     


Leu Phe Lys Trp Tyr Val Leu Met Tyr Ile Leu Leu Pro Thr Glu Ile 
            580                 585                 590         


Arg Gly Asp Phe Leu Gly Phe Val Lys Asn Gln Tyr Tyr Glu Leu Lys 
        595                 600                 605             


His Val Asp Tyr Ile Glu Asp Gln Val Ile Glu Lys Asp Leu Phe Phe 
    610                 615                 620                 


His Arg Met Arg Leu Phe Glu Lys Asn Thr Lys Lys Leu Ser Phe Ile 
625                 630                 635                 640 


Ser Tyr Gly Ile Asp Ser Leu Phe Asp Ile Lys Glu Tyr Phe Asn Tyr 
                645                 650                 655     


Leu Leu Pro Gln Leu Asn Pro Met Glu Met Asp Asp His Phe Val Asn 
            660                 665                 670         


Asn Phe Thr Arg Ser Met Val Leu Pro Met Leu Lys Tyr Tyr Gln Asn 
        675                 680                 685             


Ile Phe Lys Leu Leu Asn Asp Leu Glu Val Ala Ser Leu Ile Lys Tyr 
    690                 695                 700                 


Ser Asn Val Asn Asn Ile His Leu Leu Ser Glu Ala Ile Ala Asn Glu 
705                 710                 715                 720 


Lys Leu Lys Lys Asn Gly Asn Tyr Asn Phe Asn Thr Met Leu Gln Glu 
                725                 730                 735     


Thr Tyr Cys Ile Asp Ala Lys Cys Gly Trp Glu Leu Ser Arg Leu Arg 
            740                 745                 750         


Asn Glu Ile Ala His Leu Asn Ile Asp Arg Leu Phe Ile Glu Ile Pro 
        755                 760                 765             


Lys Asn Asp Glu Leu Asp Arg Asp Ile Asp Lys Leu Ile Asp Phe Leu 
    770                 775                 780                 


Lys Lys Pro Glu Val Asn Asn Asn Gly Met Ala Lys Thr Ile Ile Asn 
785                 790                 795                 800 


Asp Phe Tyr Met Arg His Glu Gln Phe Met His Lys Leu Asn Val Gln 
                805                 810                 815     


Ile Asn Asp Ser Thr Ser Lys Gln Glu Leu Glu Asp Lys Tyr Lys Ala 
            820                 825                 830         


Gln Lys Lys Leu Leu Asn Arg Phe Gln Met Asn Pro Glu Ala Ala Thr 
        835                 840                 845             


Ile Leu Lys Lys Tyr Glu Glu Leu Lys Ala Ile Glu Asn Ile Asn Gln 
    850                 855                 860                 


Ile Asp Leu Asp Leu Trp Gly Lys Ile Gly Asp Ile Glu Ile Ile Asp 
865                 870                 875                 880 


His Lys Lys His Lys Lys Ile Ser Asp Leu Lys Pro Leu Glu Arg Asn 
                885                 890                 895     


Leu Lys Gly Asp Leu Ile Ile Asp Lys Ile Asn Glu Met Ala Glu Leu 
            900                 905                 910         


Leu Phe Gly Ile Tyr Lys Arg Tyr Met Val Arg Asp Ile Lys Lys Ile 
        915                 920                 925             


Leu His Lys Gln Leu Thr Lys Asn Glu Ser Arg Tyr Ile Asn Leu Leu 
    930                 935                 940                 


Ile Tyr Asp Lys Met Asn Ser Glu Glu Ala Leu Arg Asn Lys Glu Ile 
945                 950                 955                 960 


Ile Tyr Thr Val His Met Lys Lys Asp Lys Glu Lys Trp Lys Ile Glu 
                965                 970                 975     


Asn Asp Glu Val Val Asn Glu Val Met Gln Leu His Asn Ile Glu Ile 
            980                 985                 990         


Ile Ser Asn Glu Lys Gly Leu Leu  Arg Cys Ile Pro Lys  Asn Glu Ala 
        995                 1000                 1005             


Ser Ile  Met Glu Leu Asp Ile  Asn Arg Ser Tyr Ile  Gln Lys Met 
    1010                 1015                 1020             


Lys Ile  Ile Val Ser Asn Asn  Ser Val Asp His Glu  
    1025                 1030                 1035 


<210>  2787
<211>  1149
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2787

Met Ala Lys Glu Ile Lys Ser Asn Arg Ser Ser Ile Ile Arg Ile Ile 
1               5                   10                  15      


Ile Ser Asn Tyr Asp Asn Lys Gly Ile Lys Glu Val Lys Val Arg Tyr 
            20                  25                  30          


Asn Lys Gln Ala Gln Leu Asp Thr Phe Ile Ile Glu Ser Gln Ile Glu 
        35                  40                  45              


Glu Gly Ala Phe Ile Leu Lys Asn Ile Lys Trp Lys Ala Lys Glu Lys 
    50                  55                  60                  


Tyr Arg Tyr Glu Met Leu Ile Lys Glu Leu Asn Asn Thr Ser Val Glu 
65                  70                  75                  80  


Ile Ile Lys Lys Asp Lys Phe Leu Asn Asn Glu Ile Val Arg Ser Tyr 
                85                  90                  95      


Arg Leu Asn Phe Lys Ile Ser Pro Lys Asn Lys Asp Val Val Val Val 
            100                 105                 110         


Glu Ile Glu Asp Leu Leu Ser Leu Glu Pro Val Gln Gln Arg Glu Arg 
        115                 120                 125             


Val Asn Val Arg Arg Ile Thr Ser Gln Thr Glu Arg Lys Leu Leu Asn 
    130                 135                 140                 


Ile Glu Thr Gln Ile Ser Tyr Ser Lys Ile Ala Ser Cys Phe Pro Glu 
145                 150                 155                 160 


Asp Ile Asp Ser Ile Lys Ile Tyr Lys Ile Lys Arg Tyr Leu Asn Tyr 
                165                 170                 175     


Arg Ser Asn Met Leu Leu Phe Phe Ser Leu Ile Asn Asp Phe Leu Cys 
            180                 185                 190         


Glu Gly Leu Tyr Asp Glu Lys Gly Asn Lys Ile Asn Glu Leu Trp Arg 
        195                 200                 205             


Ile Thr Asn Lys Val Asp Lys Asn Ile Ile Asp Glu Arg Val Asn Lys 
    210                 215                 220                 


Ile Ala Lys Asn Leu Asp Asn Thr Leu Ser Ile Glu Leu Lys Asn Tyr 
225                 230                 235                 240 


Asn Asn Arg Ile Lys Lys Ser Ile Glu Lys Lys Lys Asn Ser Ile Thr 
                245                 250                 255     


Asp Cys Lys Asn Lys Ile Val Ser Cys Glu Arg Lys Ile Glu Lys Leu 
            260                 265                 270         


Asp Glu Glu Lys Asp Arg Lys Lys Ile Ser Gln Phe Lys Arg Asp Ile 
        275                 280                 285             


Ala Asn Cys Asn Glu Lys Ile Lys Glu Tyr Glu Glu Asn Ile Val Leu 
    290                 295                 300                 


Lys Glu Lys Glu Lys Leu Phe Asn Leu Gly Phe Glu Lys Ile Lys Asp 
305                 310                 315                 320 


Asp Val Tyr Lys Val Leu Glu Ile Tyr Thr Glu Leu Arg His Lys Leu 
                325                 330                 335     


Ser His Tyr Asn Tyr Ile Tyr Phe Glu Asn Leu Phe Glu Asn Arg Glu 
            340                 345                 350         


Glu Asp Leu Lys Leu Ala Glu Leu Leu Asn Leu Asn Ile Phe Asn Tyr 
        355                 360                 365             


Leu Thr Leu Ser Lys Lys Leu Arg Ile Glu Asn Lys Thr Asn Tyr Leu 
    370                 375                 380                 


Glu Glu Asp Thr Lys Phe Ser Ile Leu Gly Val Ser Gly Ser Ala Lys 
385                 390                 395                 400 


Lys Tyr Tyr Ser Leu Tyr Asn Thr Leu Cys Glu Gln Lys Asn Gly Phe 
                405                 410                 415     


Asn Asn Phe Ile Asn Ser Phe Phe Val Lys Asp Gly Val Glu Asn Ser 
            420                 425                 430         


Glu Phe Lys Glu Lys Val Glu Ala Lys Leu Lys Glu Asp Ile Glu Tyr 
        435                 440                 445             


Leu Glu Ser Leu Glu Ile Lys Asn Asn Leu Asn Lys Arg Ile Pro Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Glu Leu Leu Lys Ser Gln Tyr Asn Glu Leu Gly 
465                 470                 475                 480 


Thr Val Tyr Phe Trp Asp Ile His Ser Ser Leu Asn Tyr Lys Glu Leu 
                485                 490                 495     


Tyr Asn Lys Arg Lys Gly Thr Ile Glu Asn Tyr Asn Gln Ile Leu Lys 
            500                 505                 510         


Gly Asn Arg Asn Lys Thr Thr Leu Arg Asn Tyr Glu Arg Glu Leu Phe 
        515                 520                 525             


Ser Lys Lys Asn Glu Met Glu Lys Ile Thr Lys Arg Asn Ser Ile Val 
    530                 535                 540                 


Arg Leu Lys Tyr Lys Leu Gln Ile Ala Tyr Ala Phe Ile Met Lys Glu 
545                 550                 555                 560 


Phe Lys Gly Asp Ile Ser Arg Phe Lys Ser Asp Phe Asp Ile Ser Lys 
                565                 570                 575     


Ile Glu Gln Ile Lys Glu Tyr Gln Ser Arg Gly Glu Glu Tyr Leu Asn 
            580                 585                 590         


Tyr Cys Asp Gln Asn Asn Phe Lys Ile Lys Asp Phe Gln Lys Met Ile 
        595                 600                 605             


Gly Glu Ile Glu Ser Ser Ser Glu Ile Thr Trp Leu Ser Asn Lys Val 
    610                 615                 620                 


Glu Asn Asn Leu Phe Lys Phe Tyr Val Leu Thr Tyr Ile Leu Leu Pro 
625                 630                 635                 640 


Ile Glu Phe Lys Gly Asp Phe Leu Gly Phe Val Lys Lys His Tyr Tyr 
                645                 650                 655     


Asp Ile Lys Asn Val Glu Tyr Leu Asp Glu Asn Leu Asn Glu Leu Thr 
            660                 665                 670         


Asn Glu Glu Leu Asp Lys Ile Lys Asn Asp Ser Phe Phe Asn Lys Ile 
        675                 680                 685             


Arg Leu Phe Glu Lys Asn Ser Lys Lys Tyr Asn Ile Phe Ser Lys Ser 
    690                 695                 700                 


Ile Leu Thr Gln Glu Arg Val Lys Asp Tyr Phe Lys Arg Leu Asp Ile 
705                 710                 715                 720 


Thr Ala Lys His Tyr Glu Tyr Thr Gly Ser Ser Gly Glu Thr Lys Asn 
                725                 730                 735     


Ile Phe Asn Lys Asn Ile Val Ile Pro Ile Phe Lys Tyr Tyr Glu Ile 
            740                 745                 750         


Val Val Lys Leu Tyr Asn Asp Ile Glu Ile Ala Met Leu Leu Tyr Leu 
        755                 760                 765             


Ser Asn Ile Lys Asn Ile Ser Ile Lys Glu Val Ile Asn Arg Ile Ile 
    770                 775                 780                 


Glu Lys Gln Ser Ser Leu Lys Glu Gly His Lys Glu Phe Tyr Thr Leu 
785                 790                 795                 800 


Thr Glu Leu Phe Gly Phe Phe Lys Leu Ala Asn Glu Lys Val Glu Glu 
                805                 810                 815     


Phe Asp Ser Asn Met Pro Ile Pro Lys Lys Tyr Leu Asn Ser Lys Pro 
            820                 825                 830         


Val Leu Leu Arg Asn Asn Ile Phe His Tyr Asn Tyr Glu Gly Phe Ile 
        835                 840                 845             


Glu Lys Leu Leu Asp Ile Asp Ser Glu Gly Thr Ser Thr Phe Ser Val 
    850                 855                 860                 


Asn Val Glu Ile Gly Lys Leu Phe Lys Phe Ile Asp Pro Tyr Leu Lys 
865                 870                 875                 880 


Glu Phe Lys Ile Leu His Leu Asp Tyr Asn Phe Ile Asn Asp Tyr Tyr 
                885                 890                 895     


Met Lys Lys Glu Gln Phe Met Phe Gly Gln Leu Lys Gln Val Asp Phe 
            900                 905                 910         


Thr Ile Thr Asn Asn Glu Glu Lys Glu Arg Val Ile Lys Asn Lys Arg 
        915                 920                 925             


Leu Leu Glu Ile Cys Lys Leu Lys Leu Glu Lys Asp Asn Ile Glu Asp 
    930                 935                 940                 


Ile Asn Lys Ile Tyr Glu Lys Ser Val Leu Leu Lys Glu Ile Gly Glu 
945                 950                 955                 960 


Thr Leu Lys Ile Glu Thr Phe Asn Asp Leu Asn Ser Leu Lys Glu Asn 
                965                 970                 975     


Arg Val Asn Leu Asn Lys Ile Asn Tyr Ile Glu Asp Leu Cys Lys Lys 
            980                 985                 990         


Gln Lys Lys Asn Lys Gln Lys Ile  Asp Val Asn Lys Val  Lys Glu Glu 
        995                 1000                 1005             


Ile Ile  Lys Cys Ser Ser Asp  Val Leu Gly Leu Tyr  Lys Gln Gln 
    1010                 1015                 1020             


Ile Ile  Thr Leu Leu Lys Asn  Lys Ile Ile Arg Lys  Leu Lys Tyr 
    1025                 1030                 1035             


Lys Glu  Glu Lys Leu Leu Thr  Val Ile Thr Tyr Glu  Ile Glu Thr 
    1040                 1045                 1050             


Lys Ala  Lys Asn Ile Tyr Thr  Ile Leu Ile Gly Arg  Lys Asn Ser 
    1055                 1060                 1065             


Ser Asp  Ser Phe Tyr Phe Leu  Asn Gly Ser Pro Asn  Lys Gln Gln 
    1070                 1075                 1080             


Ile Glu  Ile Gly Lys Lys Thr  Lys Leu Ile Leu Glu  Ile Gly Ile 
    1085                 1090                 1095             


Gln Asp  Lys Glu Lys Thr Arg  Ile Asn Thr Ser Asn  Leu Tyr Phe 
    1100                 1105                 1110             


Ser Leu  Asn Lys Lys Thr Gly  Lys Glu Lys Val Phe  Asn Lys Glu 
    1115                 1120                 1125             


Asn Ile  Asp Leu Arg Glu His  Tyr Ser Tyr Leu Val  Glu Val Lys 
    1130                 1135                 1140             


Phe Lys  Asp Leu Asn Lys 
    1145                 


<210>  2788
<211>  1094
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2788

Met Glu Lys Arg Lys Asn Lys Ser Ser Ile Ile Arg Ile Ile Ile Ser 
1               5                   10                  15      


Asn Phe Asn Ser Val Glu Met Lys Glu Phe Lys Val Leu Tyr Thr Lys 
            20                  25                  30          


Gln Gly Gly Val Asp Thr Phe Leu Thr Thr Thr Lys Phe Asp Asp Asn 
        35                  40                  45              


Gly Lys Leu Ile Phe Thr Ser Val Lys Glu Lys Ala Arg Asn Lys Lys 
    50                  55                  60                  


Phe Tyr Asp Ile Glu Val Val Val Leu Glu Asn Gly Asn Lys Ile Glu 
65                  70                  75                  80  


Ile Lys Lys Tyr Asp Lys Ile Arg Asn Gln Leu Ile Arg Tyr Tyr Glu 
                85                  90                  95      


Val Glu Gly Thr Tyr Lys Asn Thr Asn Asn His Gly Lys Lys Ile Ile 
            100                 105                 110         


Leu Lys Val Thr Asp Leu Tyr Tyr Asp Asn Ile Ser Asn Pro Arg Gly 
        115                 120                 125             


Ile Arg Ser Lys Thr Ser Glu Thr Glu Arg Leu Leu Leu Ser Lys Asp 
    130                 135                 140                 


Leu Ile Arg Lys Tyr Ser Lys Ile Ala Leu Cys Ser Glu Asp Glu Ile 
145                 150                 155                 160 


Asp Ser Lys Lys Leu Tyr Lys Ile Lys Lys Phe Phe Asn Tyr Arg Ser 
                165                 170                 175     


Asn Met Leu Ile Tyr Phe Asn Phe Ile Asn Asp Phe Leu Thr Lys Gly 
            180                 185                 190         


Thr Glu Lys Lys Glu Leu Trp Glu Ile Asp Thr Asn Ser Asn Glu Asn 
        195                 200                 205             


Met Asp Ile Ile Leu Glu Asn Ile Lys Asn Tyr Leu Ser Ile Gly Ile 
    210                 215                 220                 


Glu Asn Tyr Asn Asn Tyr Val Lys Asn Ile Asn Lys Lys Ile Ser Arg 
225                 230                 235                 240 


Glu Asn Glu Glu Ala Leu Gln Leu Arg Glu Leu Ser Glu Asp Glu Leu 
                245                 250                 255     


Arg Glu Asp Ile Leu Lys Ile Ile Lys Ile Phe Ser Ser Phe Arg His 
            260                 265                 270         


Lys Leu Met His Tyr Asn Tyr Glu Phe Phe Glu Lys Leu Phe Asp Asn 
        275                 280                 285             


Glu Lys Val Asp Leu Phe Gln Glu Asp Leu Arg Glu Leu Leu Asn Leu 
    290                 295                 300                 


Asn Leu Phe Lys Ile Ile Asp Leu Leu Lys Val Glu Arg Val Arg Asn 
305                 310                 315                 320 


Lys Thr Asn Tyr Ile Thr Lys Asp Ser Lys Ile Ile Leu Leu Gly Lys 
                325                 330                 335     


Ile Arg Ser Ala Lys Thr Thr Tyr Glu Phe Tyr Asn Asp Leu Cys Gly 
            340                 345                 350         


Arg Lys Asn Gly Phe Asn Asn Phe Ile Asn Gly Phe Phe Val Lys Asp 
        355                 360                 365             


Gly Ile Glu Asp Ser Asp Phe Lys Glu Val Ile Arg Asn Ser Phe Asn 
    370                 375                 380                 


Glu Asp Tyr Lys Arg Leu Glu Lys Lys Lys Leu Lys Asp Glu Asn Lys 
385                 390                 395                 400 


Pro Gly Lys Lys Lys Asn Asn Pro Gly Asp Tyr Asn Lys Phe Leu Glu 
                405                 410                 415     


Lys Ile Tyr Asn Phe Gln Asn Glu Tyr Lys Asp Ile Phe Tyr Trp Asp 
            420                 425                 430         


Ile Asn Asp Ser Pro Lys Tyr Lys Glu Leu Tyr Asn Glu Arg Lys Glu 
        435                 440                 445             


Leu Ile Glu Lys Tyr Asn Lys Gln Ile Asn Gly Ile Arg Asp Lys Lys 
    450                 455                 460                 


Tyr Ile Ala Glu Leu Asn Lys Lys Leu Leu Ser Lys Lys Val Lys Met 
465                 470                 475                 480 


Asp Lys Ile Thr Lys Asp Asn Ser Leu Ile Arg Leu Arg Tyr Lys Leu 
                485                 490                 495     


Gln Ile Ala Tyr Gly Phe Leu Met Glu Glu Phe Lys Gly Asp Ile Glu 
            500                 505                 510         


Lys Phe Lys Thr Lys Phe Asp Thr Ser Arg Leu Glu Glu Ile Gln Gly 
        515                 520                 525             


Tyr Tyr Lys Lys Arg Asn Asp Tyr Leu Asn Tyr Gln Val Asp Asp Lys 
    530                 535                 540                 


Val Lys Leu Asn Met Asn Ser Leu Lys Asn Leu Phe Asp Glu Thr Tyr 
545                 550                 555                 560 


Ile Asn Gln Pro Asp Lys Ile Asn Glu Lys Asn Tyr Ser Met Lys Phe 
                565                 570                 575     


Tyr Ile Leu Asn Tyr Ile Leu Leu Pro Thr Glu Ile Arg Gly Asp Phe 
            580                 585                 590         


Leu Gly Phe Ile Lys Lys Tyr Tyr Tyr Asp Ile Lys Asn Val Asp Phe 
        595                 600                 605             


Val Asp Glu Asn Leu Lys Glu Asn Glu Leu Glu Lys Cys Leu Glu Lys 
    610                 615                 620                 


Glu Thr Phe Phe His Asp Ile Arg Leu Phe Glu Lys Asn Ile Lys His 
625                 630                 635                 640 


Tyr Gln Leu Ile Asn Tyr Glu Leu Val Asp Phe Tyr Asn Leu Arg Asp 
                645                 650                 655     


Lys Leu Gly Glu Tyr Leu Glu Ser Leu Lys Ile Thr Asn Trp Arg Ser 
            660                 665                 670         


Gln Asn Tyr Arg Asn Ser Ser Asp Arg Asn Ile Phe Gly Lys Asn Ile 
        675                 680                 685             


Ile Leu Pro Ile Phe Lys Phe Tyr Glu Asn Ile Phe Lys Leu Leu Asn 
    690                 695                 700                 


Asp Ile Glu Leu His Ser Ile Phe His Leu Met Glu Lys Asn Ser Trp 
705                 710                 715                 720 


Asn Ile Ile Glu Glu Ala Ile Leu Thr Ile Asn Glu Gly Ala Glu Asn 
                725                 730                 735     


Pro Leu Arg Ile Asn Phe Ser Lys Leu Leu Asn Ser Ile Ala Ser Ser 
            740                 745                 750         


Asn Arg Lys Pro Lys Val Ala Ile Asp Phe Gln Ile Arg Asn Asp Ile 
        755                 760                 765             


Ala His Met Ser Tyr Tyr Asn Thr Leu Glu Asn Ile Leu Phe Glu Thr 
    770                 775                 780                 


Asp Ile Asp Phe Tyr Ser His Leu Ser Glu Lys Ala Ile Lys Glu Leu 
785                 790                 795                 800 


Ser Asp Lys Lys Ile Lys Gln Val Glu Lys Lys Lys Val Glu Thr Ile 
                805                 810                 815     


Asn Glu Arg Val Asp Thr Ile Ile Asn Gly Ser Glu Val Arg Lys Ile 
            820                 825                 830         


Leu Asn Met Asn Leu Gly Phe Asn Phe Ile Asn Asp Tyr Tyr Met Arg 
        835                 840                 845             


Lys Glu Lys Phe Ile Phe Asn Gln Arg Gly Leu Glu Lys Glu Asp Ile 
    850                 855                 860                 


Leu Asn Pro Gln Gln Lys Glu Gln Lys Glu Met Glu Lys Glu Ile Leu 
865                 870                 875                 880 


Ser Phe Tyr Lys Val Asn Arg Asp Asn Gln Ile Ser Leu Asn Lys Leu 
                885                 890                 895     


Tyr Ser Tyr Gly Lys Asp Leu Leu Glu Gly Asn Tyr Lys Ser Asn Lys 
            900                 905                 910         


Glu Leu Trp Asn Ile Leu Gln Asn Lys Lys Ile Ile Met Asn Lys Gly 
        915                 920                 925             


Glu Thr Asn Thr Leu Ser Tyr Tyr His Lys Asn Pro Ser Glu Glu Gln 
    930                 935                 940                 


Leu Asp Lys Ile Lys Lys Phe Ile Tyr Arg Glu Gly Ser His Leu Leu 
945                 950                 955                 960 


Gly Val Tyr Lys Lys Ile Met Ile Arg Lys Ile Lys Glu Ser Leu Ile 
                965                 970                 975     


Lys Lys Phe Thr Lys Asn Glu Asn Lys Tyr Leu Lys Val Ile Leu Thr 
            980                 985                 990         


Asp Thr Ser Ser Leu Glu Lys Asn  Lys Asn Lys Glu Tyr  Thr Val Ile 
        995                 1000                 1005             


Leu Lys  Arg Glu Asp Ile Ser  Glu Lys Phe Ile Ile  Leu Asp Glu 
    1010                 1015                 1020             


Lys Asn  Leu Asn Asn Lys Glu  Gly Leu Lys Arg Lys  Asp Ile Thr 
    1025                 1030                 1035             


Lys Glu  Ile Glu Ile Ile Thr  Asp Asp Asn Glu Lys  Phe Tyr Leu 
    1040                 1045                 1050             


Asn Asn  Lys Glu Asn Phe Glu  Glu Lys Arg Leu Ile  Val Asp Phe 
    1055                 1060                 1065             


Ser Lys  Lys Phe Asn Glu Glu  Asn Asn Asn Lys Ile  Phe Val Pro 
    1070                 1075                 1080             


Gly Lys  Tyr Ile Tyr Lys Ile  Lys Glu Lys Ile 
    1085                 1090                 


<210>  2789
<211>  1149
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2789

Met Glu Asn Lys Asn Lys Ser Asn Arg Gly Ser Ile Val Arg Ile Ile 
1               5                   10                  15      


Ile Ser Asn Tyr Asp Met Lys Gly Ile Lys Glu Leu Lys Val Arg Tyr 
            20                  25                  30          


Arg Lys Gln Ala Gln Leu Asp Thr Phe Ile Leu Gln Thr Thr Leu Asp 
        35                  40                  45              


Lys Ser Asn Asn Ser Ile Leu Ile Ser Glu Phe Arg Val Lys Val Arg 
    50                  55                  60                  


Glu Lys Tyr Arg Tyr Ser Phe Thr Tyr Asp Gly Lys Glu Lys Phe Ser 
65                  70                  75                  80  


Val Pro Ser Asn Ser Val Ile Val Thr Lys Ile Asp Asn Ala Ala Pro 
                85                  90                  95      


Glu Lys Ser Lys Glu Ile Arg Lys Tyr Lys Ile Thr Leu Gly Ile Asp 
            100                 105                 110         


Glu Lys Cys Lys Thr Gly Ser Met Ile Thr Ala Ala Ile Glu Asp Leu 
        115                 120                 125             


Leu Glu Asp Asp Arg Val Arg Glu Gly Ile Arg Asn Pro Arg Arg Lys 
    130                 135                 140                 


Val Ser Lys Thr Glu Arg Lys Leu Ile Ala Glu Thr Ile Cys His Asn 
145                 150                 155                 160 


Tyr Ala Gln Ile Ala Gln Cys Pro Val Glu Glu Ile Asp Ala Val Lys 
                165                 170                 175     


Ile Tyr Lys Val Lys Arg Phe Leu Ser Tyr Arg Ser Asn Met Leu Leu 
            180                 185                 190         


Phe Phe Ala Leu Ile Asn Asp Phe Leu Cys Lys Asn Leu Lys Asp Lys 
        195                 200                 205             


Lys Gly Glu Lys Ile Arg Glu Ile Trp Lys Ile Glu Asn Lys Gly Asn 
    210                 215                 220                 


Lys Asn Trp Ile Asp Tyr Asp Arg Tyr Tyr Asn Ile Leu Val Ala Gln 
225                 230                 235                 240 


Ile Lys Glu Tyr Phe Thr Lys Glu Ile Glu Asn Tyr Asn Asn Arg Ile 
                245                 250                 255     


Asp Asn Ile Ile Ser Lys Lys Glu Leu Leu Lys Tyr Ser Glu Glu Lys 
            260                 265                 270         


Lys Glu Ser Glu Lys Asn Lys Lys Leu Glu Glu Leu Asn Lys Leu Glu 
        275                 280                 285             


Ser Gln Lys Leu Gln Ile Leu Thr Asp Glu Glu Ile Lys Ala Asp Val 
    290                 295                 300                 


Ile Lys Ile Ile Lys Ile Phe Ser Asp Leu Arg His Ser Leu Met His 
305                 310                 315                 320 


Tyr Glu Tyr Lys Tyr Phe Glu Asn Leu Phe Glu Asn Lys Lys Asn Glu 
                325                 330                 335     


Glu Leu Ala Glu Leu Leu Asn Leu Asn Leu Phe Lys Asn Leu Thr Leu 
            340                 345                 350         


Leu Arg Gln Met Lys Ile Glu Asn Lys Thr Asn Tyr Leu Glu Gly Ser 
        355                 360                 365             


Glu Lys Phe Asn Ile Ile Gly Lys Asn Ile Lys Ala Lys Glu Val Leu 
    370                 375                 380                 


Gly His Tyr Asn Leu Leu Ala Glu Gln Lys Asn Gly Phe Asn Asn Phe 
385                 390                 395                 400 


Ile Asn Ser Phe Phe Val Gln Asp Gly Val Glu Asn Leu Glu Phe Lys 
                405                 410                 415     


Lys Leu Ile Asp Glu Asn Phe Ile Lys Ala Gln Lys Glu Leu Glu Glu 
            420                 425                 430         


Asp Ile Lys Asn Cys Lys Glu Ser Val Lys Lys Leu Glu Lys Lys Leu 
        435                 440                 445             


Lys Glu Asn Pro Lys Lys Ser Glu Asp Leu Glu Lys Lys Leu Glu Lys 
    450                 455                 460                 


Lys Gln Lys Lys Leu Lys Glu Leu Lys Gln Glu Leu Glu Lys Met Lys 
465                 470                 475                 480 


Gln His Tyr Gln Arg Leu Asn Cys Ala Tyr Val Trp Asp Ile His Ser 
                485                 490                 495     


Ser Thr Val Tyr Lys Lys Leu Tyr Asn Lys Arg Lys Ser Leu Ile Glu 
            500                 505                 510         


Glu Tyr Asn Lys Gln Ile Asn Glu Ile Lys Asp Lys Glu Ala Ile Thr 
        515                 520                 525             


Ala Ile Asn Ala Glu Leu Leu Arg Ile Lys Lys Glu Met Glu Glu Ile 
    530                 535                 540                 


Thr Lys Ser Asn Ser Leu Phe Arg Leu Lys Tyr Lys Met Gln Ile Ala 
545                 550                 555                 560 


Tyr Ala Phe Leu Glu Ile Glu Phe Gly Gly Ser Ile Ala Lys Phe Lys 
                565                 570                 575     


Asp Glu Phe Asp Cys Ser Lys Met Glu Glu Val Gln Glu Tyr Leu Lys 
            580                 585                 590         


Lys Asp Ile Lys Tyr Leu Lys Tyr Tyr Lys Asp Lys Glu Ala Gln Lys 
        595                 600                 605             


Asn Tyr Glu Phe Pro Phe Glu Glu Ile Phe Glu Ile Lys Asp Thr His 
    610                 615                 620                 


Asn Glu Glu Trp Leu Glu Asn Thr Ser Glu Asn Asn Leu Phe Lys Phe 
625                 630                 635                 640 


Tyr Ile Leu Thr Tyr Leu Leu Leu Pro Met Glu Phe Lys Gly Asp Phe 
                645                 650                 655     


Leu Gly Val Val Lys Lys His Tyr Tyr Asp Ile Lys Asn Val Asp Phe 
            660                 665                 670         


Thr Asp Glu Ser Glu Lys Glu Leu Ser Gln Glu Gln Ile Asp Lys Met 
        675                 680                 685             


Ile Gly Asp Ser Phe Phe His Lys Ile Arg Leu Phe Glu Lys Asn Thr 
    690                 695                 700                 


Lys Arg Tyr Glu Ile Ile Lys Tyr Ser Ile Leu Thr Ser Asp Glu Ile 
705                 710                 715                 720 


Lys Lys Tyr Phe Glu Ser Leu Glu Leu Asp Val Pro Tyr Phe Glu Tyr 
                725                 730                 735     


Glu Lys Gly Thr Asp Lys Ile Gly Ile Phe Asn Lys Asn Ile Ile Leu 
            740                 745                 750         


Thr Ile Phe Lys Tyr Tyr Gln Ile Ile Phe Lys Leu Tyr Asn Asp Leu 
        755                 760                 765             


Glu Ile His Gly Leu Phe Asn Ile Ser Ser Asp Leu Asn Lys Ile Leu 
    770                 775                 780                 


Ser Asp Leu Lys Ser Asn Gly Asn Lys Asn Ile Asn Phe Gly Lys Leu 
785                 790                 795                 800 


Leu Tyr Leu Ile Lys Gln Asn Asn Asn Leu Ser Ala Glu Glu Asn His 
                805                 810                 815     


Gln Lys Ile Gln Lys Asn Leu Glu Val Glu Tyr Trp Lys Lys Ser Leu 
            820                 825                 830         


Pro Thr Pro Glu Lys Lys Glu Ile Lys Ile Lys Thr Glu Glu Glu Leu 
        835                 840                 845             


Glu Lys Leu Lys Lys Ile Ser Asp Leu Arg Asn Gly Ile Cys His Leu 
    850                 855                 860                 


Asn Tyr Lys Glu Met Ile Glu Glu Ile Leu Lys Pro Glu Ile Ser Glu 
865                 870                 875                 880 


Lys Asn Lys Glu Ala Thr Leu Asn Glu Lys Ile Arg Glu Leu Ile Asn 
                885                 890                 895     


Phe Ile Lys Glu Asn Glu Leu Asp Lys Val Glu Leu Gly Phe Asn Phe 
            900                 905                 910         


Ile Asn Asp Phe Phe Met Lys Lys Glu Gln Phe Met Phe Gly Gln Ile 
        915                 920                 925             


Lys Gln Val Lys Glu Gly Asn Ser Asp Ser Ile Thr Thr Glu Arg Glu 
    930                 935                 940                 


Lys Lys Glu Lys Asn Asn Lys Lys Leu Lys Glu Thr Tyr Glu Leu Asn 
945                 950                 955                 960 


Tyr Asp Asn Leu Ser Glu Phe Tyr Glu Thr Ser Asn Asn Leu Arg Glu 
                965                 970                 975     


Arg Ala Asn Ser Ser Ser Leu Leu Glu Asp Ser Ala Phe Leu Lys Lys 
            980                 985                 990         


Val Gly Leu Tyr Lys Ile Ile Pro  Glu Lys Arg Arg Asn  Asn Lys Ala 
        995                 1000                 1005             


Asn Thr  Lys Val Lys Asp Glu  Glu Lys Arg Ile Glu  Asn Ile Lys 
    1010                 1015                 1020             


Arg Lys  Leu Leu Lys Asp Ser  Ser Asp Ile Met Gly  Met Tyr Lys 
    1025                 1030                 1035             


Ala Glu  Val Val Lys Lys Leu  Lys Glu Lys Leu Ile  Leu Ile Phe 
    1040                 1045                 1050             


Lys His  Asp Glu Glu Lys Arg  Ile Tyr Val Thr Val  Tyr Asp Thr 
    1055                 1060                 1065             


Ser Lys  Ala Val Pro Glu Asn  Ile Ser Lys Glu Ile  Leu Val Lys 
    1070                 1075                 1080             


Arg Asn  Asn Ser Lys Glu Glu  Tyr Ser Phe Glu Asp  Asn Asn Lys 
    1085                 1090                 1095             


Lys Tyr  Val Thr Glu Tyr Tyr  Thr Leu Glu Ile Thr  Glu Thr Asn 
    1100                 1105                 1110             


Glu Leu  Lys Val Ile Pro Ala  Lys Lys Leu Glu Gly  Lys Glu Phe 
    1115                 1120                 1125             


Lys Thr  Glu Lys Asn Lys Leu  Met Leu Asn Asn His  Tyr Cys Phe 
    1130                 1135                 1140             


Asn Val  Lys Ile Ile Tyr 
    1145                 


<210>  2790
<211>  1149
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2790

Met Ala Lys Glu Ile Lys Ser Asn Arg Ser Ser Ile Ile Arg Ile Ile 
1               5                   10                  15      


Ile Ser Asn Tyr Asp Asn Lys Gly Ile Lys Glu Val Lys Val Arg Tyr 
            20                  25                  30          


Asn Lys Gln Ala Gln Leu Asp Thr Phe Ile Ile Glu Ser Gln Ile Glu 
        35                  40                  45              


Glu Gly Ala Phe Ile Leu Lys Asn Ile Lys Trp Lys Ala Lys Glu Lys 
    50                  55                  60                  


Tyr Arg Tyr Glu Met Leu Ile Lys Glu Leu Asn Asn Thr Ser Val Glu 
65                  70                  75                  80  


Ile Ile Lys Lys Asp Lys Phe Leu Asn Asn Glu Ile Val Arg Ser Tyr 
                85                  90                  95      


Arg Leu Asn Phe Lys Ile Ser Pro Lys Asn Lys Asp Val Val Val Val 
            100                 105                 110         


Glu Ile Glu Asp Leu Leu Ser Leu Glu Pro Val Gln Gln Arg Glu Arg 
        115                 120                 125             


Val Asn Val Arg Arg Ile Thr Ser Gln Thr Glu Arg Lys Leu Leu Asn 
    130                 135                 140                 


Ile Glu Thr Gln Ile Ser Tyr Ser Lys Ile Ala Ser Cys Phe Pro Glu 
145                 150                 155                 160 


Asp Ile Asp Ser Ile Lys Ile Tyr Lys Ile Lys Arg Tyr Leu Asn Tyr 
                165                 170                 175     


Arg Ser Asn Met Leu Leu Phe Phe Ser Leu Ile Asn Asp Phe Leu Cys 
            180                 185                 190         


Glu Gly Leu Tyr Asp Glu Lys Gly Asn Lys Ile Asn Glu Leu Trp Arg 
        195                 200                 205             


Ile Thr Asn Lys Val Asp Lys Asn Ile Ile Asp Glu Arg Val Asn Lys 
    210                 215                 220                 


Ile Ala Lys Asn Leu Asp Asn Thr Leu Ser Ile Glu Leu Lys Asn Tyr 
225                 230                 235                 240 


Asn Asn Arg Ile Lys Lys Ser Ile Glu Lys Lys Lys Asn Ser Ile Thr 
                245                 250                 255     


Asp Cys Lys Asn Lys Ile Val Ser Cys Glu Arg Lys Ile Glu Lys Leu 
            260                 265                 270         


Asp Glu Glu Lys Asp Arg Lys Lys Ile Ser Gln Phe Lys Arg Asp Ile 
        275                 280                 285             


Ala Asn Cys Asn Glu Lys Ile Lys Glu Tyr Glu Glu Asn Ile Val Leu 
    290                 295                 300                 


Lys Glu Lys Glu Lys Leu Phe Asn Leu Gly Phe Glu Lys Ile Lys Asp 
305                 310                 315                 320 


Asp Val Tyr Lys Val Leu Glu Ile Tyr Thr Glu Leu Arg His Lys Leu 
                325                 330                 335     


Ser His Tyr Asn Tyr Ile Tyr Phe Glu Asn Leu Phe Glu Asn Arg Glu 
            340                 345                 350         


Glu Asp Leu Lys Leu Ala Glu Leu Leu Asn Leu Asn Ile Phe Asn Tyr 
        355                 360                 365             


Leu Thr Leu Ser Lys Lys Leu Arg Ile Glu Asn Lys Thr Asn Tyr Leu 
    370                 375                 380                 


Glu Glu Asp Thr Lys Phe Ser Ile Leu Gly Val Ser Gly Ser Ala Lys 
385                 390                 395                 400 


Lys Tyr Tyr Ser Leu Tyr Asn Thr Leu Cys Glu Gln Lys Asn Gly Phe 
                405                 410                 415     


Asn Asn Phe Ile Asn Ser Phe Phe Val Lys Asp Gly Val Glu Asn Ser 
            420                 425                 430         


Glu Phe Lys Glu Lys Val Glu Ala Lys Leu Lys Glu Asp Ile Glu Tyr 
        435                 440                 445             


Leu Glu Ser Leu Glu Ile Lys Asn Asn Leu Asn Lys Arg Ile Pro Lys 
    450                 455                 460                 


Lys Asn Lys Glu Leu Glu Leu Leu Lys Ser Gln Tyr Asn Glu Leu Gly 
465                 470                 475                 480 


Thr Val Tyr Phe Trp Asp Ile His Ser Ser Leu Asn Tyr Lys Glu Leu 
                485                 490                 495     


Tyr Asn Lys Arg Lys Gly Thr Ile Glu Asn Tyr Asn Gln Ile Leu Lys 
            500                 505                 510         


Gly Asn Arg Asn Lys Thr Thr Leu Arg Asn Tyr Glu Arg Glu Leu Phe 
        515                 520                 525             


Ser Lys Lys Asn Glu Met Glu Lys Ile Thr Lys Arg Asn Ser Ile Val 
    530                 535                 540                 


Arg Leu Lys Tyr Lys Leu Gln Ile Ala Tyr Ala Phe Ile Met Lys Glu 
545                 550                 555                 560 


Phe Lys Gly Asp Ile Ser Arg Phe Lys Ser Asp Phe Asp Ile Ser Lys 
                565                 570                 575     


Ile Glu Gln Ile Lys Glu Tyr Gln Ser Arg Gly Glu Glu Tyr Leu Asn 
            580                 585                 590         


Tyr Cys Asp Gln Asn Asn Phe Lys Ile Lys Asp Phe Gln Lys Met Ile 
        595                 600                 605             


Gly Glu Ile Glu Ser Ser Ser Glu Ile Thr Trp Leu Ser Asn Lys Val 
    610                 615                 620                 


Glu Asn Asn Leu Phe Lys Phe Tyr Val Leu Thr Tyr Ile Leu Leu Pro 
625                 630                 635                 640 


Ile Glu Phe Lys Gly Asp Phe Leu Gly Phe Val Lys Lys His Tyr Tyr 
                645                 650                 655     


Asp Ile Lys Asn Val Glu Tyr Leu Asp Glu Asn Leu Asn Glu Leu Thr 
            660                 665                 670         


Asn Glu Glu Leu Asp Lys Ile Lys Asn Asp Ser Phe Phe Asn Lys Ile 
        675                 680                 685             


Arg Leu Phe Glu Lys Asn Ser Lys Lys Tyr Asn Ile Phe Ser Lys Ser 
    690                 695                 700                 


Ile Leu Thr Gln Glu Arg Val Lys Asp Tyr Phe Lys Arg Leu Asp Ile 
705                 710                 715                 720 


Thr Ala Lys His Tyr Glu Tyr Thr Gly Ser Ser Gly Glu Thr Lys Asn 
                725                 730                 735     


Ile Phe Asn Lys Asn Ile Val Ile Pro Ile Phe Lys Tyr Tyr Glu Ile 
            740                 745                 750         


Val Val Lys Leu Tyr Asn Asp Ile Glu Ile Ala Met Leu Leu Tyr Leu 
        755                 760                 765             


Ser Asn Ile Lys Asn Ile Ser Ile Lys Glu Val Ile Asn Arg Ile Ile 
    770                 775                 780                 


Glu Lys Gln Ser Ser Leu Lys Glu Gly His Lys Glu Phe Tyr Thr Leu 
785                 790                 795                 800 


Thr Glu Leu Phe Gly Phe Phe Lys Leu Ala Asn Glu Lys Val Glu Glu 
                805                 810                 815     


Phe Asp Ser Asn Met Pro Ile Pro Lys Lys Tyr Leu Asn Ser Lys Pro 
            820                 825                 830         


Val Leu Leu Arg Asn Asn Ile Phe His Tyr Asn Tyr Glu Gly Phe Ile 
        835                 840                 845             


Glu Lys Leu Leu Asp Ile Asp Ser Glu Gly Thr Ser Thr Phe Ser Val 
    850                 855                 860                 


Asn Val Glu Ile Gly Lys Leu Phe Lys Phe Ile Asp Pro Tyr Leu Lys 
865                 870                 875                 880 


Glu Phe Lys Ile Leu His Leu Asp Tyr Asn Phe Ile Asn Asp Tyr Tyr 
                885                 890                 895     


Met Lys Lys Glu Gln Phe Met Phe Gly Gln Leu Lys Gln Val Asp Phe 
            900                 905                 910         


Thr Ile Thr Asn Asn Glu Glu Lys Glu Arg Val Ile Lys Asn Lys Arg 
        915                 920                 925             


Leu Leu Glu Ile Cys Lys Leu Lys Leu Glu Lys Asp Asn Ile Glu Asp 
    930                 935                 940                 


Ile Asn Lys Ile Tyr Glu Lys Ser Val Leu Leu Lys Glu Ile Gly Glu 
945                 950                 955                 960 


Thr Leu Lys Ile Glu Thr Phe Asn Asp Leu Asn Ser Leu Lys Glu Asn 
                965                 970                 975     


Arg Val Asn Leu Asn Lys Ile Asn Tyr Ile Glu Asp Leu Cys Lys Lys 
            980                 985                 990         


Gln Lys Lys Asn Lys Gln Lys Ile  Asp Val Asn Lys Val  Lys Glu Glu 
        995                 1000                 1005             


Ile Ile  Lys Cys Ser Ser Asp  Val Leu Gly Leu Tyr  Lys Gln Gln 
    1010                 1015                 1020             


Ile Ile  Thr Leu Leu Lys Asn  Lys Ile Ile Arg Lys  Leu Lys Tyr 
    1025                 1030                 1035             


Lys Glu  Glu Lys Leu Leu Thr  Val Ile Thr Tyr Glu  Ile Glu Thr 
    1040                 1045                 1050             


Lys Ala  Lys Asn Ile Tyr Thr  Ile Leu Ile Gly Arg  Lys Asn Ser 
    1055                 1060                 1065             


Ser Asp  Ser Phe Tyr Phe Leu  Asn Gly Ser Pro Asn  Lys Gln Gln 
    1070                 1075                 1080             


Ile Glu  Ile Gly Lys Lys Thr  Lys Leu Ile Leu Glu  Ile Gly Ile 
    1085                 1090                 1095             


Gln Asp  Lys Glu Lys Thr Arg  Ile Asn Thr Ser Asn  Leu Tyr Phe 
    1100                 1105                 1110             


Ser Leu  Asn Lys Lys Thr Gly  Lys Glu Lys Val Phe  Asn Lys Glu 
    1115                 1120                 1125             


Asn Ile  Asp Leu Arg Glu His  Tyr Ser Tyr Leu Val  Glu Val Lys 
    1130                 1135                 1140             


Phe Lys  Asp Leu Asn Lys 
    1145                 


<210>  2791
<211>  1035
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2791

Met Thr Asn Asn Lys Lys Pro Ala Asn Lys Asn Ser Ile Ile Arg Val 
1               5                   10                  15      


Ile Ile Ser Asn Phe Asp Glu Asn Ser Ile Lys Glu Ile Lys Val Leu 
            20                  25                  30          


Tyr Thr Lys Gln Gly Gly Val Asp Thr Ile His Ile Lys Lys Met Ser 
        35                  40                  45              


Met Cys Glu Glu Asp Lys Ser Leu Tyr Phe Glu Glu Val Glu Cys Asn 
    50                  55                  60                  


Ser Gln Phe Gly Asn Ile Asp Ile Lys Ile Glu Lys Asp Asn Arg Ser 
65                  70                  75                  80  


Val Ile Val Glu Lys Tyr Asp Lys Tyr Thr Gly Leu Ile Ile Arg Lys 
                85                  90                  95      


Tyr Lys Ile Phe Gly Thr Tyr Val Ile Thr Asn Lys Asn Ile Lys Leu 
            100                 105                 110         


Val Lys Val Tyr Val Gln Asp Ile Leu Asn Glu Lys Ser Thr Asn Lys 
        115                 120                 125             


Arg Arg Ile Glu Ser Tyr Thr Glu Arg Leu Leu Ile Asp Pro Ala Val 
    130                 135                 140                 


Ile Asn Asp Tyr Lys Lys Ile Met Glu Asn Asn Gln Asp Ile Asp Ser 
145                 150                 155                 160 


Lys Asn Ile Tyr Lys Leu Asn Arg Phe Ile Asn Tyr Arg Ser Asn Met 
                165                 170                 175     


Met Leu Tyr Phe Thr Phe Val Tyr Arg Phe Leu Gly Met Glu Leu Gly 
            180                 185                 190         


Thr Asn Gly Glu Val Tyr Lys Leu Asp Gln Glu Cys Asn Leu Glu Lys 
        195                 200                 205             


Gln Lys Lys Val Val Asp Tyr Val Ala Ser Asn Ile Glu Lys Phe Val 
    210                 215                 220                 


Glu Asn His Asn Asn Tyr Ala Gln Lys Arg Asn Glu Glu Thr Glu Glu 
225                 230                 235                 240 


Lys Lys Leu His Arg Asp Lys Glu Ile Leu Ile Glu Ile Asp Lys Lys 
                245                 250                 255     


Leu Leu Glu Lys Asp Ile Lys Asn Ile Ile Thr Ile Val Ala Ser Val 
            260                 265                 270         


Arg His Lys Leu Ala His Tyr Asn Tyr Thr Phe Phe Gln Asp Leu Leu 
        275                 280                 285             


Glu Gly Lys Glu Ile Val Leu Glu Lys Gln Lys Pro Leu Asn Glu Leu 
    290                 295                 300                 


Leu Asp Leu Asn Ile Phe Lys Glu Ile Gly Lys Ile Lys Asn Leu Lys 
305                 310                 315                 320 


Glu Glu Lys Ala Thr Thr Tyr Leu Glu Asp Asp Thr Lys Val Tyr Val 
                325                 330                 335     


Leu Gly Lys His Lys Lys Ala Lys Lys Leu Tyr Asn Tyr Tyr Asp Lys 
            340                 345                 350         


Leu Cys Thr Arg Lys Asp Gly Phe Asn Asn Phe Ile Asn Ser Phe Phe 
        355                 360                 365             


Ser Val Asp Gly Asn Glu Asn Pro Asp Phe Lys Lys His Ile Asn Glu 
    370                 375                 380                 


His Phe Glu Lys Arg Ile Asp Glu Leu Asn Tyr Gln Val Asn Asn Thr 
385                 390                 395                 400 


Lys Lys Val Arg Glu Asp Ile Lys Arg Glu Leu Val Glu Met Gln Glu 
                405                 410                 415     


Ile Lys Lys Leu Ile Gly Glu Ala Tyr Ile Trp Asp Ile His Gln Cys 
            420                 425                 430         


Lys Glu Tyr Lys Arg Ile Tyr Asn Lys Arg Lys Asn Leu Val Glu Glu 
        435                 440                 445             


Val Ser Gln Leu Ser Arg Lys Ala Asn Arg Asp Lys Val Asp Lys Asp 
    450                 455                 460                 


Lys Ile Ser Lys Leu Asn Asn Glu Ile Leu Lys Met Asn Thr Gln Met 
465                 470                 475                 480 


Glu Lys Tyr Thr Lys Leu Asn Ser Lys Phe Arg Leu Gln Tyr Lys Leu 
                485                 490                 495     


Gln Met Ala Tyr Gly Phe Leu Tyr Glu Glu Tyr Gly Phe Asp Leu Lys 
            500                 505                 510         


Arg Phe Gly Asp Arg Phe Asn Ser Ser Ile Leu Asp Glu Leu Lys Pro 
        515                 520                 525             


Tyr Lys Glu Asn Gly Leu Lys Tyr Leu Lys Thr Lys Val Thr Ser Asn 
    530                 535                 540                 


Asp Asn Ile Gly Phe Ser Leu Gly Glu Phe Glu Lys Lys Ile Asn Ala 
545                 550                 555                 560 


Met Lys Ala Met Asp Asn Gly Leu Phe Asn Pro Thr His Ser Asn Asn 
                565                 570                 575     


Leu Phe Lys Trp Tyr Val Leu Met Tyr Ile Leu Leu Pro Thr Glu Ile 
            580                 585                 590         


Arg Gly Asp Phe Leu Gly Phe Val Lys Asn Gln Tyr Tyr Glu Leu Lys 
        595                 600                 605             


His Val Asp Tyr Ile Glu Asp Gln Val Ile Glu Lys Asp Leu Phe Phe 
    610                 615                 620                 


His Arg Met Arg Leu Phe Glu Lys Asn Thr Lys Lys Leu Ser Phe Ile 
625                 630                 635                 640 


Ser Tyr Gly Ile Asp Ser Leu Phe Asp Ile Lys Glu Tyr Phe Asn Tyr 
                645                 650                 655     


Leu Leu Pro Gln Leu Asn Pro Met Glu Met Asp Asp His Phe Val Asn 
            660                 665                 670         


Asn Phe Thr Arg Ser Met Val Leu Pro Met Leu Lys Tyr Tyr Gln Asn 
        675                 680                 685             


Ile Phe Lys Leu Leu Asn Asp Leu Glu Val Ala Ser Leu Ile Lys Tyr 
    690                 695                 700                 


Ser Asn Val Asn Asn Ile His Leu Leu Ser Glu Ala Ile Ala Asn Glu 
705                 710                 715                 720 


Lys Leu Lys Lys Asn Gly Asn Tyr Asn Phe Asn Thr Met Leu Gln Glu 
                725                 730                 735     


Thr Tyr Cys Ile Asp Ala Lys Cys Gly Trp Glu Leu Ser Arg Leu Arg 
            740                 745                 750         


Asn Glu Ile Ala His Leu Asn Ile Asp Arg Leu Phe Ile Glu Ile Pro 
        755                 760                 765             


Lys Asn Asp Glu Leu Asp Arg Asp Ile Asp Lys Leu Ile Asp Phe Leu 
    770                 775                 780                 


Lys Lys Pro Glu Val Asn Asn Asn Gly Met Ala Lys Thr Ile Ile Asn 
785                 790                 795                 800 


Asp Phe Tyr Met Arg His Glu Gln Phe Met His Lys Leu Asn Val Gln 
                805                 810                 815     


Ile Asn Asp Ser Thr Ser Lys Gln Glu Leu Glu Asp Lys Tyr Lys Ala 
            820                 825                 830         


Gln Lys Lys Leu Leu Asn Arg Phe Gln Met Asn Pro Glu Ala Ala Thr 
        835                 840                 845             


Ile Leu Lys Lys Tyr Glu Glu Leu Lys Ala Ile Glu Asn Ile Asn Gln 
    850                 855                 860                 


Ile Asp Leu Asp Leu Trp Gly Lys Ile Gly Asp Ile Glu Ile Ile Asp 
865                 870                 875                 880 


His Lys Lys His Lys Lys Ile Ser Asp Leu Lys Pro Leu Glu Arg Asn 
                885                 890                 895     


Leu Lys Gly Asp Leu Ile Ile Asp Lys Ile Asn Glu Met Ala Glu Leu 
            900                 905                 910         


Leu Phe Gly Ile Tyr Lys Arg Tyr Met Val Arg Asp Ile Lys Lys Ile 
        915                 920                 925             


Leu His Lys Gln Leu Thr Lys Asn Glu Ser Arg Tyr Ile Asn Leu Leu 
    930                 935                 940                 


Ile Tyr Asp Lys Met Asn Ser Glu Glu Ala Leu Arg Asn Lys Glu Ile 
945                 950                 955                 960 


Ile Tyr Thr Val His Met Lys Lys Asp Lys Glu Lys Trp Lys Ile Glu 
                965                 970                 975     


Asn Asp Glu Val Val Asn Glu Val Met Gln Leu His Asn Ile Glu Ile 
            980                 985                 990         


Ile Ser Asn Glu Lys Gly Leu Leu  Arg Cys Ile Pro Lys  Asn Glu Ala 
        995                 1000                 1005             


Ser Ile  Met Glu Leu Asp Ile  Asn Arg Ser Tyr Ile  Gln Lys Met 
    1010                 1015                 1020             


Lys Ile  Ile Val Ser Asn Asn  Ser Val Asp His Glu  
    1025                 1030                 1035 


<210>  2792
<211>  1035
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2792

Met Thr Asn Asn Lys Lys Pro Ala Asn Lys Asn Ser Ile Ile Arg Val 
1               5                   10                  15      


Ile Ile Ser Asn Phe Asp Glu Asn Ser Ile Lys Glu Ile Lys Val Leu 
            20                  25                  30          


Tyr Thr Lys Gln Gly Gly Val Asp Thr Ile His Ile Lys Lys Met Ser 
        35                  40                  45              


Met Cys Glu Glu Asp Lys Ser Leu Tyr Phe Glu Glu Val Glu Cys Asn 
    50                  55                  60                  


Ser Gln Phe Gly Asn Ile Asp Ile Lys Ile Glu Lys Asp Asn Arg Ser 
65                  70                  75                  80  


Val Ile Val Glu Lys Tyr Asp Lys Tyr Thr Gly Leu Ile Ile Arg Lys 
                85                  90                  95      


Tyr Lys Ile Phe Gly Thr Tyr Val Ile Thr Asn Lys Asn Ile Lys Leu 
            100                 105                 110         


Val Lys Val Tyr Val Gln Asp Ile Leu Asn Glu Lys Ser Thr Asn Lys 
        115                 120                 125             


Arg Arg Ile Glu Ser Tyr Thr Glu Arg Leu Leu Ile Asp Pro Ala Val 
    130                 135                 140                 


Ile Asn Asp Tyr Lys Lys Ile Met Glu Asn Asn Gln Asp Ile Asp Ser 
145                 150                 155                 160 


Lys Asn Ile Tyr Lys Leu Asn Arg Phe Ile Asn Tyr Arg Ser Asn Met 
                165                 170                 175     


Met Leu Tyr Phe Thr Phe Val Tyr Arg Phe Leu Gly Met Glu Leu Gly 
            180                 185                 190         


Thr Asn Gly Glu Val Tyr Lys Leu Asp Gln Glu Cys Asn Leu Glu Lys 
        195                 200                 205             


Gln Lys Lys Val Val Asp Tyr Val Ala Ser Asn Ile Glu Lys Phe Val 
    210                 215                 220                 


Glu Asn His Asn Asn Tyr Ala Gln Lys Arg Asn Glu Glu Thr Glu Glu 
225                 230                 235                 240 


Lys Lys Leu His Arg Asp Lys Glu Ile Leu Ile Glu Ile Asp Lys Lys 
                245                 250                 255     


Leu Leu Glu Lys Asp Ile Lys Asn Ile Ile Thr Ile Val Ala Ser Val 
            260                 265                 270         


Arg His Lys Leu Ala His Tyr Asn Tyr Thr Phe Phe Gln Asp Leu Leu 
        275                 280                 285             


Glu Gly Lys Glu Ile Val Leu Glu Lys Gln Lys Pro Leu Asn Glu Leu 
    290                 295                 300                 


Leu Asp Leu Asn Ile Phe Lys Glu Ile Gly Lys Ile Lys Asn Leu Lys 
305                 310                 315                 320 


Glu Glu Lys Ala Thr Thr Tyr Leu Glu Asp Asp Thr Lys Val Tyr Val 
                325                 330                 335     


Leu Gly Lys His Lys Lys Ala Lys Lys Leu Tyr Asn Tyr Tyr Asp Lys 
            340                 345                 350         


Leu Cys Thr Arg Lys Asp Gly Phe Asn Asn Phe Ile Asn Ser Phe Phe 
        355                 360                 365             


Ser Val Asp Gly Asn Glu Asn Pro Asp Phe Lys Lys His Ile Asn Glu 
    370                 375                 380                 


His Phe Glu Lys Arg Ile Asp Glu Leu Asn Tyr Gln Val Asn Asn Thr 
385                 390                 395                 400 


Lys Lys Val Arg Glu Asp Ile Lys Arg Glu Leu Val Glu Met Gln Glu 
                405                 410                 415     


Ile Lys Lys Leu Ile Gly Glu Ala Tyr Ile Trp Asp Ile His Gln Cys 
            420                 425                 430         


Lys Glu Tyr Lys Arg Ile Tyr Asn Lys Arg Lys Asn Leu Val Glu Glu 
        435                 440                 445             


Val Ser Gln Leu Ser Arg Lys Ala Asn Arg Asp Lys Val Asp Lys Asp 
    450                 455                 460                 


Lys Ile Ser Lys Leu Asn Asn Glu Ile Leu Lys Met Asn Thr Gln Met 
465                 470                 475                 480 


Glu Lys Tyr Thr Lys Leu Asn Ser Lys Phe Arg Leu Gln Tyr Lys Leu 
                485                 490                 495     


Gln Met Ala Tyr Gly Phe Leu Tyr Glu Glu Tyr Gly Phe Asp Leu Lys 
            500                 505                 510         


Arg Phe Gly Asp Arg Phe Asn Ser Ser Ile Leu Asp Glu Leu Lys Pro 
        515                 520                 525             


Tyr Lys Glu Asn Gly Leu Lys Tyr Leu Lys Thr Lys Val Thr Ser Asn 
    530                 535                 540                 


Asp Asn Ile Gly Phe Ser Leu Gly Glu Phe Glu Lys Lys Ile Asn Ala 
545                 550                 555                 560 


Met Lys Ala Met Asp Asn Gly Leu Phe Asn Pro Thr His Ser Asn Asn 
                565                 570                 575     


Leu Phe Lys Trp Tyr Val Leu Met Tyr Ile Leu Leu Pro Thr Glu Ile 
            580                 585                 590         


Arg Gly Asp Phe Leu Gly Phe Val Lys Asn Gln Tyr Tyr Glu Leu Lys 
        595                 600                 605             


His Val Asp Tyr Ile Glu Asp Gln Val Ile Glu Lys Asp Leu Phe Phe 
    610                 615                 620                 


His Arg Met Arg Leu Phe Glu Lys Asn Thr Lys Lys Leu Ser Phe Ile 
625                 630                 635                 640 


Ser Tyr Gly Ile Asp Ser Leu Phe Asp Ile Lys Glu Tyr Phe Asn Tyr 
                645                 650                 655     


Leu Leu Pro Gln Leu Asn Pro Met Glu Met Asp Asp His Phe Val Asn 
            660                 665                 670         


Asn Phe Thr Arg Ser Met Val Leu Pro Met Leu Lys Tyr Tyr Gln Asn 
        675                 680                 685             


Ile Phe Lys Leu Leu Asn Asp Leu Glu Val Ala Ser Leu Ile Lys Tyr 
    690                 695                 700                 


Ser Asn Val Asn Asn Ile His Leu Leu Ser Glu Ala Ile Ala Asn Glu 
705                 710                 715                 720 


Lys Leu Lys Lys Asn Gly Asn Tyr Asn Phe Asn Thr Met Leu Gln Glu 
                725                 730                 735     


Thr Tyr Cys Ile Asp Ala Lys Cys Gly Trp Glu Leu Ser Arg Leu Arg 
            740                 745                 750         


Asn Glu Ile Ala His Leu Asn Ile Asp Arg Leu Phe Ile Glu Ile Pro 
        755                 760                 765             


Lys Asn Asp Glu Leu Asp Arg Asp Ile Asp Lys Leu Ile Asp Phe Leu 
    770                 775                 780                 


Lys Lys Pro Glu Val Asn Asn Asn Gly Met Ala Lys Thr Ile Ile Asn 
785                 790                 795                 800 


Asp Phe Tyr Met Arg His Glu Gln Phe Met His Lys Leu Asn Val Gln 
                805                 810                 815     


Ile Asn Asp Ser Thr Ser Lys Gln Glu Leu Glu Asp Lys Tyr Lys Ala 
            820                 825                 830         


Gln Lys Lys Leu Leu Asn Arg Phe Gln Met Asn Pro Glu Ala Ala Thr 
        835                 840                 845             


Ile Leu Lys Lys Tyr Glu Glu Leu Lys Ala Ile Glu Asn Ile Asn Gln 
    850                 855                 860                 


Ile Asp Leu Asp Leu Trp Gly Lys Ile Gly Asp Ile Glu Ile Ile Asp 
865                 870                 875                 880 


His Lys Lys His Lys Lys Ile Ser Asp Leu Lys Pro Leu Glu Arg Asn 
                885                 890                 895     


Leu Lys Gly Asp Leu Ile Ile Asp Lys Ile Asn Glu Met Ala Glu Leu 
            900                 905                 910         


Leu Phe Gly Ile Tyr Lys Arg Tyr Met Val Arg Asp Ile Lys Lys Ile 
        915                 920                 925             


Leu His Lys Gln Leu Thr Lys Asn Glu Ser Arg Tyr Ile Asn Leu Leu 
    930                 935                 940                 


Ile Tyr Asp Lys Met Asn Ser Glu Glu Ala Leu Arg Asn Lys Glu Ile 
945                 950                 955                 960 


Ile Tyr Thr Val His Met Lys Lys Asp Lys Glu Lys Trp Lys Ile Glu 
                965                 970                 975     


Asn Asp Glu Val Val Asn Glu Val Met Gln Leu His Asn Ile Glu Ile 
            980                 985                 990         


Ile Ser Asn Glu Lys Gly Leu Leu  Arg Cys Ile Pro Lys  Asn Glu Ala 
        995                 1000                 1005             


Ser Ile  Met Glu Leu Asp Ile  Asn Arg Ser Tyr Ile  Gln Lys Met 
    1010                 1015                 1020             


Lys Ile  Ile Val Ser Asn Asn  Ser Val Asp His Glu  
    1025                 1030                 1035 


<210>  2793
<211>  1035
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2793

Met Thr Asn Asn Lys Lys Pro Ala Asn Lys Asn Ser Ile Ile Arg Val 
1               5                   10                  15      


Ile Ile Ser Asn Phe Asp Glu Asn Ser Ile Lys Glu Ile Lys Val Leu 
            20                  25                  30          


Tyr Thr Lys Gln Gly Gly Val Asp Thr Ile His Ile Lys Lys Met Ser 
        35                  40                  45              


Met Cys Glu Glu Asp Lys Ser Leu Tyr Phe Glu Glu Val Glu Cys Asn 
    50                  55                  60                  


Ser Gln Phe Gly Asn Ile Asp Ile Lys Ile Glu Lys Asp Asn Arg Ser 
65                  70                  75                  80  


Val Ile Val Glu Lys Tyr Asp Lys Tyr Thr Gly Leu Ile Ile Arg Lys 
                85                  90                  95      


Tyr Lys Ile Phe Gly Thr Tyr Val Ile Thr Asn Lys Asn Ile Lys Leu 
            100                 105                 110         


Val Lys Val Tyr Val Gln Asp Ile Leu Asn Glu Lys Ser Thr Asn Lys 
        115                 120                 125             


Arg Arg Ile Glu Ser Tyr Thr Glu Arg Leu Leu Ile Asp Pro Ala Val 
    130                 135                 140                 


Ile Asn Asp Tyr Lys Lys Ile Met Glu Asn Asn Gln Asp Ile Asp Ser 
145                 150                 155                 160 


Lys Asn Ile Tyr Lys Leu Asn Arg Phe Ile Asn Tyr Arg Ser Asn Met 
                165                 170                 175     


Met Leu Tyr Phe Thr Phe Val Tyr Arg Phe Leu Gly Met Glu Leu Gly 
            180                 185                 190         


Thr Asn Gly Glu Val Tyr Lys Leu Asp Gln Glu Cys Asn Leu Glu Lys 
        195                 200                 205             


Gln Lys Lys Val Val Asp Tyr Val Ala Ser Asn Ile Glu Lys Phe Val 
    210                 215                 220                 


Glu Asn His Asn Asn Tyr Ala Gln Lys Arg Asn Glu Glu Thr Glu Glu 
225                 230                 235                 240 


Lys Lys Leu His Arg Asp Lys Glu Ile Leu Ile Glu Ile Asp Lys Lys 
                245                 250                 255     


Leu Leu Glu Lys Asp Ile Lys Asn Ile Ile Thr Ile Val Ala Ser Val 
            260                 265                 270         


Arg His Lys Leu Ala His Tyr Asn Tyr Thr Phe Phe Gln Asp Leu Leu 
        275                 280                 285             


Glu Gly Lys Glu Ile Val Leu Glu Lys Gln Lys Pro Leu Asn Glu Leu 
    290                 295                 300                 


Leu Asp Leu Asn Ile Phe Lys Glu Ile Gly Lys Ile Lys Asn Leu Lys 
305                 310                 315                 320 


Glu Glu Lys Ala Thr Thr Tyr Leu Glu Asp Asp Thr Lys Val Tyr Val 
                325                 330                 335     


Leu Gly Lys His Lys Lys Ala Lys Lys Leu Tyr Asn Tyr Tyr Asp Lys 
            340                 345                 350         


Leu Cys Thr Arg Lys Asp Gly Phe Asn Asn Phe Ile Asn Ser Phe Phe 
        355                 360                 365             


Ser Val Asp Gly Asn Glu Asn Pro Asp Phe Lys Lys His Ile Asn Glu 
    370                 375                 380                 


His Phe Glu Lys Arg Ile Asp Glu Leu Asn Tyr Gln Val Asn Asn Thr 
385                 390                 395                 400 


Lys Lys Val Arg Glu Asp Ile Lys Arg Glu Leu Val Glu Met Gln Glu 
                405                 410                 415     


Ile Lys Lys Leu Ile Gly Glu Ala Tyr Ile Trp Asp Ile His Gln Cys 
            420                 425                 430         


Lys Glu Tyr Lys Arg Ile Tyr Asn Lys Arg Lys Asn Leu Val Glu Glu 
        435                 440                 445             


Val Ser Gln Leu Ser Arg Lys Ala Asn Arg Asp Lys Val Asp Lys Asp 
    450                 455                 460                 


Lys Ile Ser Lys Leu Asn Asn Glu Ile Leu Lys Met Asn Thr Gln Met 
465                 470                 475                 480 


Glu Lys Tyr Thr Lys Leu Asn Ser Lys Phe Arg Leu Gln Tyr Lys Leu 
                485                 490                 495     


Gln Met Ala Tyr Gly Phe Leu Tyr Glu Glu Tyr Gly Phe Asp Leu Lys 
            500                 505                 510         


Arg Phe Gly Asp Arg Phe Asn Ser Ser Ile Leu Asp Glu Leu Lys Pro 
        515                 520                 525             


Tyr Lys Glu Asn Gly Leu Lys Tyr Leu Lys Thr Lys Val Thr Ser Asn 
    530                 535                 540                 


Asp Asn Ile Gly Phe Ser Leu Gly Glu Phe Glu Lys Lys Ile Asn Ala 
545                 550                 555                 560 


Met Lys Ala Met Asp Asn Gly Leu Phe Asn Pro Thr His Ser Asn Asn 
                565                 570                 575     


Leu Phe Lys Trp Tyr Val Leu Met Tyr Ile Leu Leu Pro Thr Glu Ile 
            580                 585                 590         


Arg Gly Asp Phe Leu Gly Phe Val Lys Asn Gln Tyr Tyr Glu Leu Lys 
        595                 600                 605             


His Val Asp Tyr Ile Glu Asp Gln Val Ile Glu Lys Asp Leu Phe Phe 
    610                 615                 620                 


His Arg Met Arg Leu Phe Glu Lys Asn Thr Lys Lys Leu Ser Phe Ile 
625                 630                 635                 640 


Ser Tyr Gly Ile Asp Ser Leu Phe Asp Ile Lys Glu Tyr Phe Asn Tyr 
                645                 650                 655     


Leu Leu Pro Gln Leu Asn Pro Met Glu Met Asp Asp His Phe Val Asn 
            660                 665                 670         


Asn Phe Thr Arg Ser Met Val Leu Pro Met Leu Lys Tyr Tyr Gln Asn 
        675                 680                 685             


Ile Phe Lys Leu Leu Asn Asp Leu Glu Val Ala Ser Leu Ile Lys Tyr 
    690                 695                 700                 


Ser Asn Val Asn Asn Ile His Leu Leu Ser Glu Ala Ile Ala Asn Glu 
705                 710                 715                 720 


Lys Leu Lys Lys Asn Gly Asn Tyr Asn Phe Asn Thr Met Leu Gln Glu 
                725                 730                 735     


Thr Tyr Cys Ile Asp Ala Lys Cys Gly Trp Glu Leu Ser Arg Leu Arg 
            740                 745                 750         


Asn Glu Ile Ala His Leu Asn Ile Asp Arg Leu Phe Ile Glu Ile Pro 
        755                 760                 765             


Lys Asn Asp Glu Leu Asp Arg Asp Ile Asp Lys Leu Ile Asp Phe Leu 
    770                 775                 780                 


Lys Lys Pro Glu Val Asn Asn Asn Gly Met Ala Lys Thr Ile Ile Asn 
785                 790                 795                 800 


Asp Phe Tyr Met Arg His Glu Gln Phe Met His Lys Leu Asn Val Gln 
                805                 810                 815     


Ile Asn Asp Ser Thr Ser Lys Gln Glu Leu Glu Asp Lys Tyr Lys Ala 
            820                 825                 830         


Gln Lys Lys Leu Leu Asn Arg Phe Gln Met Asn Pro Glu Ala Ala Thr 
        835                 840                 845             


Ile Leu Lys Lys Tyr Glu Glu Leu Lys Ala Ile Glu Asn Ile Asn Gln 
    850                 855                 860                 


Ile Asp Leu Asp Leu Trp Gly Lys Ile Gly Asp Ile Glu Ile Ile Asp 
865                 870                 875                 880 


His Lys Lys His Lys Lys Ile Ser Asp Leu Lys Pro Leu Glu Arg Asn 
                885                 890                 895     


Leu Lys Gly Asp Leu Ile Ile Asp Lys Ile Asn Glu Met Ala Glu Leu 
            900                 905                 910         


Leu Phe Gly Ile Tyr Lys Arg Tyr Met Val Arg Asp Ile Lys Lys Ile 
        915                 920                 925             


Leu His Lys Gln Leu Thr Lys Asn Glu Ser Arg Tyr Ile Asn Leu Leu 
    930                 935                 940                 


Ile Tyr Asp Lys Met Asn Ser Glu Glu Ala Leu Arg Asn Lys Glu Ile 
945                 950                 955                 960 


Ile Tyr Thr Val His Met Lys Lys Asp Lys Glu Lys Trp Lys Ile Glu 
                965                 970                 975     


Asn Asp Glu Val Val Asn Glu Val Met Gln Leu His Asn Ile Glu Ile 
            980                 985                 990         


Ile Ser Asn Glu Lys Gly Leu Leu  Arg Cys Ile Pro Lys  Asn Glu Ala 
        995                 1000                 1005             


Ser Ile  Met Glu Leu Asp Ile  Asn Arg Ser Tyr Ile  Gln Lys Met 
    1010                 1015                 1020             


Lys Ile  Ile Val Ser Asn Asn  Ser Val Asp His Glu  
    1025                 1030                 1035 


<210>  2794
<211>  1035
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2794

Met Thr Asn Asn Lys Lys Pro Ala Asn Lys Asn Ser Ile Ile Arg Val 
1               5                   10                  15      


Ile Ile Ser Asn Phe Asp Glu Asn Ser Ile Lys Glu Ile Lys Val Leu 
            20                  25                  30          


Tyr Thr Lys Gln Gly Gly Val Asp Thr Ile His Ile Lys Lys Met Ser 
        35                  40                  45              


Met Cys Glu Glu Asp Lys Ser Leu Tyr Phe Glu Glu Val Glu Cys Asn 
    50                  55                  60                  


Ser Gln Phe Gly Asn Ile Asp Ile Lys Ile Glu Lys Asp Asn Arg Ser 
65                  70                  75                  80  


Val Ile Val Glu Lys Tyr Asp Lys Tyr Thr Gly Leu Ile Ile Arg Lys 
                85                  90                  95      


Tyr Lys Ile Phe Gly Thr Tyr Val Ile Thr Asn Lys Asn Ile Lys Leu 
            100                 105                 110         


Val Lys Val Tyr Val Gln Asp Ile Leu Asn Glu Lys Ser Thr Asn Lys 
        115                 120                 125             


Arg Arg Ile Glu Ser Tyr Thr Glu Arg Leu Leu Ile Asp Pro Ala Val 
    130                 135                 140                 


Ile Asn Asp Tyr Lys Lys Ile Met Glu Asn Asn Gln Asp Ile Asp Ser 
145                 150                 155                 160 


Lys Asn Ile Tyr Lys Leu Asn Arg Phe Ile Asn Tyr Arg Ser Asn Met 
                165                 170                 175     


Met Leu Tyr Phe Thr Phe Val Tyr Arg Phe Leu Gly Met Glu Leu Gly 
            180                 185                 190         


Thr Asn Gly Glu Val Tyr Lys Leu Asp Gln Glu Cys Asn Leu Glu Lys 
        195                 200                 205             


Gln Lys Lys Val Val Asp Tyr Val Ala Ser Asn Ile Glu Lys Phe Val 
    210                 215                 220                 


Glu Asn His Asn Asn Tyr Ala Gln Lys Arg Asn Glu Glu Thr Glu Glu 
225                 230                 235                 240 


Lys Lys Leu His Arg Asp Lys Glu Ile Leu Ile Glu Ile Asp Lys Lys 
                245                 250                 255     


Leu Leu Glu Lys Asp Ile Lys Asn Ile Ile Thr Ile Val Ala Ser Val 
            260                 265                 270         


Arg His Lys Leu Ala His Tyr Asn Tyr Thr Phe Phe Gln Asp Leu Leu 
        275                 280                 285             


Glu Gly Lys Glu Ile Val Leu Glu Lys Gln Lys Pro Leu Asn Glu Leu 
    290                 295                 300                 


Leu Asp Leu Asn Ile Phe Lys Glu Ile Gly Lys Ile Lys Asn Leu Lys 
305                 310                 315                 320 


Glu Glu Lys Ala Thr Thr Tyr Leu Glu Asp Asp Thr Lys Val Tyr Val 
                325                 330                 335     


Leu Gly Lys His Lys Lys Ala Lys Lys Leu Tyr Asn Tyr Tyr Asp Lys 
            340                 345                 350         


Leu Cys Thr Arg Lys Asp Gly Phe Asn Asn Phe Ile Asn Ser Phe Phe 
        355                 360                 365             


Ser Val Asp Gly Asn Glu Asn Pro Asp Phe Lys Lys His Ile Asn Glu 
    370                 375                 380                 


His Phe Glu Lys Arg Ile Asp Glu Leu Asn Tyr Gln Val Asn Asn Thr 
385                 390                 395                 400 


Lys Lys Val Arg Glu Asp Ile Lys Arg Glu Leu Val Glu Met Gln Glu 
                405                 410                 415     


Ile Lys Lys Leu Ile Gly Glu Ala Tyr Ile Trp Asp Ile His Gln Cys 
            420                 425                 430         


Lys Glu Tyr Lys Arg Ile Tyr Asn Lys Arg Lys Asn Leu Val Glu Glu 
        435                 440                 445             


Val Ser Gln Leu Ser Arg Lys Ala Asn Arg Asp Lys Val Asp Lys Asp 
    450                 455                 460                 


Lys Ile Ser Lys Leu Asn Asn Glu Ile Leu Lys Met Asn Thr Gln Met 
465                 470                 475                 480 


Glu Lys Tyr Thr Lys Leu Asn Ser Lys Phe Arg Leu Gln Tyr Lys Leu 
                485                 490                 495     


Gln Met Ala Tyr Gly Phe Leu Tyr Glu Glu Tyr Gly Phe Asp Leu Lys 
            500                 505                 510         


Arg Phe Gly Asp Arg Phe Asn Ser Ser Ile Leu Asp Glu Leu Lys Pro 
        515                 520                 525             


Tyr Lys Glu Asn Gly Leu Lys Tyr Leu Lys Thr Lys Val Thr Ser Asn 
    530                 535                 540                 


Asp Asn Ile Gly Phe Ser Leu Gly Glu Phe Glu Lys Lys Ile Asn Ala 
545                 550                 555                 560 


Met Lys Ala Met Asp Asn Gly Leu Phe Asn Pro Thr His Ser Asn Asn 
                565                 570                 575     


Leu Phe Lys Trp Tyr Val Leu Met Tyr Ile Leu Leu Pro Thr Glu Ile 
            580                 585                 590         


Arg Gly Asp Phe Leu Gly Phe Val Lys Asn Gln Tyr Tyr Glu Leu Lys 
        595                 600                 605             


His Val Asp Tyr Ile Glu Asp Gln Val Ile Glu Lys Asp Leu Phe Phe 
    610                 615                 620                 


His Arg Met Arg Leu Phe Glu Lys Asn Thr Lys Lys Leu Ser Phe Ile 
625                 630                 635                 640 


Ser Tyr Gly Ile Asp Ser Leu Phe Asp Ile Lys Glu Tyr Phe Asn Tyr 
                645                 650                 655     


Leu Leu Pro Gln Leu Asn Pro Met Glu Met Asp Asp His Phe Val Asn 
            660                 665                 670         


Asn Phe Thr Arg Ser Met Val Leu Pro Met Leu Lys Tyr Tyr Gln Asn 
        675                 680                 685             


Ile Phe Lys Leu Leu Asn Asp Leu Glu Val Ala Ser Leu Ile Lys Tyr 
    690                 695                 700                 


Ser Asn Val Asn Asn Ile His Leu Leu Ser Glu Ala Ile Ala Asn Glu 
705                 710                 715                 720 


Lys Leu Lys Lys Asn Gly Asn Tyr Asn Phe Asn Thr Met Leu Gln Glu 
                725                 730                 735     


Thr Tyr Cys Ile Asp Ala Lys Cys Gly Trp Glu Leu Ser Arg Leu Arg 
            740                 745                 750         


Asn Glu Ile Ala His Leu Asn Ile Asp Arg Leu Phe Ile Glu Ile Pro 
        755                 760                 765             


Lys Asn Asp Glu Leu Asp Arg Asp Ile Asp Lys Leu Ile Asp Phe Leu 
    770                 775                 780                 


Lys Lys Pro Glu Val Asn Asn Asn Gly Met Ala Lys Thr Ile Ile Asn 
785                 790                 795                 800 


Asp Phe Tyr Met Arg His Glu Gln Phe Met His Lys Leu Asn Val Gln 
                805                 810                 815     


Ile Asn Asp Ser Thr Ser Lys Gln Glu Leu Glu Asp Lys Tyr Lys Ala 
            820                 825                 830         


Gln Lys Lys Leu Leu Asn Arg Phe Gln Met Asn Pro Glu Ala Ala Thr 
        835                 840                 845             


Ile Leu Lys Lys Tyr Glu Glu Leu Lys Ala Ile Glu Asn Ile Asn Gln 
    850                 855                 860                 


Ile Asp Leu Asp Leu Trp Gly Lys Ile Gly Asp Ile Glu Ile Ile Asp 
865                 870                 875                 880 


His Lys Lys His Lys Lys Ile Ser Asp Leu Lys Pro Leu Glu Arg Asn 
                885                 890                 895     


Leu Lys Gly Asp Leu Ile Ile Asp Lys Ile Asn Glu Met Ala Glu Leu 
            900                 905                 910         


Leu Phe Gly Ile Tyr Lys Arg Tyr Met Val Arg Asp Ile Lys Lys Ile 
        915                 920                 925             


Leu His Lys Gln Leu Thr Lys Asn Glu Ser Arg Tyr Ile Asn Leu Leu 
    930                 935                 940                 


Ile Tyr Asp Lys Met Asn Ser Glu Glu Ala Leu Arg Asn Lys Glu Ile 
945                 950                 955                 960 


Ile Tyr Thr Val His Met Lys Lys Asp Lys Glu Lys Trp Lys Ile Glu 
                965                 970                 975     


Asn Asp Glu Val Val Asn Glu Val Met Gln Leu His Asn Ile Glu Ile 
            980                 985                 990         


Ile Ser Asn Glu Lys Gly Leu Leu  Arg Cys Ile Pro Lys  Asn Glu Ala 
        995                 1000                 1005             


Ser Ile  Met Glu Leu Asp Ile  Asn Arg Ser Tyr Ile  Gln Lys Met 
    1010                 1015                 1020             


Lys Ile  Ile Val Ser Asn Asn  Ser Val Asp His Glu  
    1025                 1030                 1035 


<210>  2795
<211>  1035
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2795

Met Thr Asn Asn Lys Lys Pro Ala Asn Lys Asn Ser Ile Ile Arg Val 
1               5                   10                  15      


Ile Ile Ser Asn Phe Asp Glu Asn Ser Ile Lys Glu Ile Lys Val Leu 
            20                  25                  30          


Tyr Thr Lys Gln Gly Gly Val Asp Thr Ile His Ile Lys Lys Met Ser 
        35                  40                  45              


Met Cys Glu Glu Asp Lys Ser Leu Tyr Phe Glu Glu Val Glu Cys Asn 
    50                  55                  60                  


Ser Gln Phe Gly Asn Ile Asp Ile Lys Ile Glu Lys Asp Asn Arg Ser 
65                  70                  75                  80  


Val Ile Val Glu Lys Tyr Asp Lys Tyr Thr Gly Leu Ile Ile Arg Lys 
                85                  90                  95      


Tyr Lys Ile Phe Gly Thr Tyr Val Ile Thr Asn Lys Asn Ile Lys Leu 
            100                 105                 110         


Val Lys Val Tyr Val Gln Asp Ile Leu Asn Glu Lys Ser Thr Asn Lys 
        115                 120                 125             


Arg Arg Ile Glu Ser Tyr Thr Glu Arg Leu Leu Ile Asp Pro Ala Val 
    130                 135                 140                 


Ile Asn Asp Tyr Lys Lys Ile Met Glu Asn Asn Gln Asp Ile Asp Ser 
145                 150                 155                 160 


Lys Asn Ile Tyr Lys Leu Asn Arg Phe Ile Asn Tyr Arg Ser Asn Met 
                165                 170                 175     


Met Leu Tyr Phe Thr Phe Val Tyr Arg Phe Leu Gly Met Glu Leu Gly 
            180                 185                 190         


Thr Asn Gly Glu Val Tyr Lys Leu Asp Gln Glu Cys Asn Leu Glu Lys 
        195                 200                 205             


Gln Lys Lys Val Val Asp Tyr Val Ala Ser Asn Ile Glu Lys Phe Val 
    210                 215                 220                 


Glu Asn His Asn Asn Tyr Ala Gln Lys Arg Asn Glu Glu Thr Glu Glu 
225                 230                 235                 240 


Lys Lys Leu His Arg Asp Lys Glu Ile Leu Ile Glu Ile Asp Lys Lys 
                245                 250                 255     


Leu Leu Glu Lys Asp Ile Lys Asn Ile Ile Thr Ile Val Ala Ser Val 
            260                 265                 270         


Arg His Lys Leu Ala His Tyr Asn Tyr Thr Phe Phe Gln Asp Leu Leu 
        275                 280                 285             


Glu Gly Lys Glu Ile Val Leu Glu Lys Gln Lys Pro Leu Asn Glu Leu 
    290                 295                 300                 


Leu Asp Leu Asn Ile Phe Lys Glu Ile Gly Lys Ile Lys Asn Leu Lys 
305                 310                 315                 320 


Glu Glu Lys Ala Thr Thr Tyr Leu Glu Asp Asp Thr Lys Val Tyr Val 
                325                 330                 335     


Leu Gly Lys His Lys Lys Ala Lys Lys Leu Tyr Asn Tyr Tyr Asp Lys 
            340                 345                 350         


Leu Cys Thr Arg Lys Asp Gly Phe Asn Asn Phe Ile Asn Ser Phe Phe 
        355                 360                 365             


Ser Val Asp Gly Asn Glu Asn Pro Asp Phe Lys Lys His Ile Asn Glu 
    370                 375                 380                 


His Phe Glu Lys Arg Ile Asp Glu Leu Asn Tyr Gln Val Asn Asn Thr 
385                 390                 395                 400 


Lys Lys Val Arg Glu Asp Ile Lys Arg Glu Leu Val Glu Met Gln Glu 
                405                 410                 415     


Ile Lys Lys Leu Ile Gly Glu Ala Tyr Ile Trp Asp Ile His Gln Cys 
            420                 425                 430         


Lys Glu Tyr Lys Arg Ile Tyr Asn Lys Arg Lys Asn Leu Val Glu Glu 
        435                 440                 445             


Val Ser Gln Leu Ser Arg Lys Ala Asn Arg Asp Lys Val Asp Lys Asp 
    450                 455                 460                 


Lys Ile Ser Lys Leu Asn Asn Glu Ile Leu Lys Met Asn Thr Gln Met 
465                 470                 475                 480 


Glu Lys Tyr Thr Lys Leu Asn Ser Lys Phe Arg Leu Gln Tyr Lys Leu 
                485                 490                 495     


Gln Met Ala Tyr Gly Phe Leu Tyr Glu Glu Tyr Gly Phe Asp Leu Lys 
            500                 505                 510         


Arg Phe Gly Asp Arg Phe Asn Ser Ser Ile Leu Asp Glu Leu Lys Pro 
        515                 520                 525             


Tyr Lys Glu Asn Gly Leu Lys Tyr Leu Lys Thr Lys Val Thr Ser Asn 
    530                 535                 540                 


Asp Asn Ile Gly Phe Ser Leu Gly Glu Phe Glu Lys Lys Ile Asn Ala 
545                 550                 555                 560 


Met Lys Ala Met Asp Asn Gly Leu Phe Asn Pro Thr His Ser Asn Asn 
                565                 570                 575     


Leu Phe Lys Trp Tyr Val Leu Met Tyr Ile Leu Leu Pro Thr Glu Ile 
            580                 585                 590         


Arg Gly Asp Phe Leu Gly Phe Val Lys Asn Gln Tyr Tyr Glu Leu Lys 
        595                 600                 605             


His Val Asp Tyr Ile Glu Asp Gln Val Ile Glu Lys Asp Leu Phe Phe 
    610                 615                 620                 


His Arg Met Arg Leu Phe Glu Lys Asn Thr Lys Lys Leu Ser Phe Ile 
625                 630                 635                 640 


Ser Tyr Gly Ile Asp Ser Leu Phe Asp Ile Lys Glu Tyr Phe Asn Tyr 
                645                 650                 655     


Leu Leu Pro Gln Leu Asn Pro Met Glu Met Asp Asp His Phe Val Asn 
            660                 665                 670         


Asn Phe Thr Arg Ser Met Val Leu Pro Met Leu Lys Tyr Tyr Gln Asn 
        675                 680                 685             


Ile Phe Lys Leu Leu Asn Asp Leu Glu Val Ala Ser Leu Ile Lys Tyr 
    690                 695                 700                 


Ser Asn Val Asn Asn Ile His Leu Leu Ser Glu Ala Ile Ala Asn Glu 
705                 710                 715                 720 


Lys Leu Lys Lys Asn Gly Asn Tyr Asn Phe Asn Thr Met Leu Gln Glu 
                725                 730                 735     


Thr Tyr Cys Ile Asp Ala Lys Cys Gly Trp Glu Leu Ser Arg Leu Arg 
            740                 745                 750         


Asn Glu Ile Ala His Leu Asn Ile Asp Arg Leu Phe Ile Glu Ile Pro 
        755                 760                 765             


Lys Asn Asp Glu Leu Asp Arg Asp Ile Asp Lys Leu Ile Asp Phe Leu 
    770                 775                 780                 


Lys Lys Pro Glu Val Asn Asn Asn Gly Met Ala Lys Thr Ile Ile Asn 
785                 790                 795                 800 


Asp Phe Tyr Met Arg His Glu Gln Phe Met His Lys Leu Asn Val Gln 
                805                 810                 815     


Ile Asn Asp Ser Thr Ser Lys Gln Glu Leu Glu Asp Lys Tyr Lys Ala 
            820                 825                 830         


Gln Lys Lys Leu Leu Asn Arg Phe Gln Met Asn Pro Glu Ala Ala Thr 
        835                 840                 845             


Ile Leu Lys Lys Tyr Glu Glu Leu Lys Ala Ile Glu Asn Ile Asn Gln 
    850                 855                 860                 


Ile Asp Leu Asp Leu Trp Gly Lys Ile Gly Asp Ile Glu Ile Ile Asp 
865                 870                 875                 880 


His Lys Lys His Lys Lys Ile Ser Asp Leu Lys Pro Leu Glu Arg Asn 
                885                 890                 895     


Leu Lys Gly Asp Leu Ile Ile Asp Lys Ile Asn Glu Met Ala Glu Leu 
            900                 905                 910         


Leu Phe Gly Ile Tyr Lys Arg Tyr Met Val Arg Asp Ile Lys Lys Ile 
        915                 920                 925             


Leu His Lys Gln Leu Thr Lys Asn Glu Ser Arg Tyr Ile Asn Leu Leu 
    930                 935                 940                 


Ile Tyr Asp Lys Met Asn Ser Glu Glu Ala Leu Arg Asn Lys Glu Ile 
945                 950                 955                 960 


Ile Tyr Thr Val His Met Lys Lys Asp Lys Glu Lys Trp Lys Ile Glu 
                965                 970                 975     


Asn Asp Glu Val Val Asn Glu Val Met Gln Leu His Asn Ile Glu Ile 
            980                 985                 990         


Ile Ser Asn Glu Lys Gly Leu Leu  Arg Cys Ile Pro Lys  Asn Glu Ala 
        995                 1000                 1005             


Ser Ile  Met Glu Leu Asp Ile  Asn Arg Ser Tyr Ile  Gln Lys Met 
    1010                 1015                 1020             


Lys Ile  Ile Val Ser Asn Asn  Ser Val Asp His Glu  
    1025                 1030                 1035 


<210>  2796
<211>  1035
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2796

Met Thr Asn Asn Lys Lys Pro Ala Asn Lys Asn Ser Ile Ile Arg Val 
1               5                   10                  15      


Ile Ile Ser Asn Phe Asp Glu Asn Ser Ile Lys Glu Ile Lys Val Leu 
            20                  25                  30          


Tyr Thr Lys Gln Gly Gly Val Asp Thr Ile His Ile Lys Lys Met Ser 
        35                  40                  45              


Met Cys Glu Glu Asp Lys Ser Leu Tyr Phe Glu Glu Val Glu Cys Asn 
    50                  55                  60                  


Ser Gln Phe Gly Asn Ile Asp Ile Lys Ile Glu Lys Asp Asn Arg Ser 
65                  70                  75                  80  


Val Ile Val Glu Lys Tyr Asp Lys Tyr Thr Gly Leu Ile Ile Arg Lys 
                85                  90                  95      


Tyr Lys Ile Phe Gly Thr Tyr Val Ile Thr Asn Lys Asn Ile Lys Leu 
            100                 105                 110         


Val Lys Val Tyr Val Gln Asp Ile Leu Asn Glu Lys Ser Thr Asn Lys 
        115                 120                 125             


Arg Arg Ile Glu Ser Tyr Thr Glu Arg Leu Leu Ile Asp Pro Ala Val 
    130                 135                 140                 


Ile Asn Asp Tyr Lys Lys Ile Met Glu Asn Asn Gln Asp Ile Asp Ser 
145                 150                 155                 160 


Lys Asn Ile Tyr Lys Leu Asn Arg Phe Ile Asn Tyr Arg Ser Asn Met 
                165                 170                 175     


Met Leu Tyr Phe Thr Phe Val Tyr Arg Phe Leu Gly Met Glu Leu Gly 
            180                 185                 190         


Thr Asn Gly Glu Val Tyr Lys Leu Asp Gln Glu Cys Asn Leu Glu Lys 
        195                 200                 205             


Gln Lys Lys Val Val Asp Tyr Val Ala Ser Asn Ile Glu Lys Phe Val 
    210                 215                 220                 


Glu Asn His Asn Asn Tyr Ala Gln Lys Arg Asn Glu Glu Thr Glu Glu 
225                 230                 235                 240 


Lys Lys Leu His Arg Asp Lys Glu Ile Leu Ile Glu Ile Asp Lys Lys 
                245                 250                 255     


Leu Leu Glu Lys Asp Ile Lys Asn Ile Ile Thr Ile Val Ala Ser Val 
            260                 265                 270         


Arg His Lys Leu Ala His Tyr Asn Tyr Thr Phe Phe Gln Asp Leu Leu 
        275                 280                 285             


Glu Gly Lys Glu Ile Val Leu Glu Lys Gln Lys Pro Leu Asn Glu Leu 
    290                 295                 300                 


Leu Asp Leu Asn Ile Phe Lys Glu Ile Gly Lys Ile Lys Asn Leu Lys 
305                 310                 315                 320 


Glu Glu Lys Ala Thr Thr Tyr Leu Glu Asp Asp Thr Lys Val Tyr Val 
                325                 330                 335     


Leu Gly Lys His Lys Lys Ala Lys Lys Leu Tyr Asn Tyr Tyr Asp Lys 
            340                 345                 350         


Leu Cys Thr Arg Lys Asp Gly Phe Asn Asn Phe Ile Asn Ser Phe Phe 
        355                 360                 365             


Ser Val Asp Gly Asn Glu Asn Pro Asp Phe Lys Lys His Ile Asn Glu 
    370                 375                 380                 


His Phe Glu Lys Arg Ile Asp Glu Leu Asn Tyr Gln Val Asn Asn Thr 
385                 390                 395                 400 


Lys Lys Val Arg Glu Asp Ile Lys Arg Glu Leu Val Glu Met Gln Glu 
                405                 410                 415     


Ile Lys Lys Leu Ile Gly Glu Ala Tyr Ile Trp Asp Ile His Gln Cys 
            420                 425                 430         


Lys Glu Tyr Lys Arg Ile Tyr Asn Lys Arg Lys Asn Leu Val Glu Glu 
        435                 440                 445             


Val Ser Gln Leu Ser Arg Lys Ala Asn Arg Asp Lys Val Asp Lys Asp 
    450                 455                 460                 


Lys Ile Ser Lys Leu Asn Asn Glu Ile Leu Lys Met Asn Thr Gln Met 
465                 470                 475                 480 


Glu Lys Tyr Thr Lys Leu Asn Ser Lys Phe Arg Leu Gln Tyr Lys Leu 
                485                 490                 495     


Gln Met Ala Tyr Gly Phe Leu Tyr Glu Glu Tyr Gly Phe Asp Leu Lys 
            500                 505                 510         


Arg Phe Gly Asp Arg Phe Asn Ser Ser Ile Leu Asp Glu Leu Lys Pro 
        515                 520                 525             


Tyr Lys Glu Asn Gly Leu Lys Tyr Leu Lys Thr Lys Val Thr Ser Asn 
    530                 535                 540                 


Asp Asn Ile Gly Phe Ser Leu Gly Glu Phe Glu Lys Lys Ile Asn Ala 
545                 550                 555                 560 


Met Lys Ala Met Asp Asn Gly Leu Phe Asn Pro Thr His Ser Asn Asn 
                565                 570                 575     


Leu Phe Lys Trp Tyr Val Leu Met Tyr Ile Leu Leu Pro Thr Glu Ile 
            580                 585                 590         


Arg Gly Asp Phe Leu Gly Phe Val Lys Asn Gln Tyr Tyr Glu Leu Lys 
        595                 600                 605             


His Val Asp Tyr Ile Glu Asp Gln Val Ile Glu Lys Asp Leu Phe Phe 
    610                 615                 620                 


His Arg Met Arg Leu Phe Glu Lys Asn Thr Lys Lys Leu Ser Phe Ile 
625                 630                 635                 640 


Ser Tyr Gly Ile Asp Ser Leu Phe Asp Ile Lys Glu Tyr Phe Asn Tyr 
                645                 650                 655     


Leu Leu Pro Gln Leu Asn Pro Met Glu Met Asp Asp His Phe Val Asn 
            660                 665                 670         


Asn Phe Thr Arg Ser Met Val Leu Pro Met Leu Lys Tyr Tyr Gln Asn 
        675                 680                 685             


Ile Phe Lys Leu Leu Asn Asp Leu Glu Val Ala Ser Leu Ile Lys Tyr 
    690                 695                 700                 


Ser Asn Val Asn Asn Ile His Leu Leu Ser Glu Ala Ile Ala Asn Glu 
705                 710                 715                 720 


Lys Leu Lys Lys Asn Gly Asn Tyr Asn Phe Asn Thr Met Leu Gln Glu 
                725                 730                 735     


Thr Tyr Cys Ile Asp Ala Lys Cys Gly Trp Glu Leu Ser Arg Leu Arg 
            740                 745                 750         


Asn Glu Ile Ala His Leu Asn Ile Asp Arg Leu Phe Ile Glu Ile Pro 
        755                 760                 765             


Lys Asn Asp Glu Leu Asp Arg Asp Ile Asp Lys Leu Ile Asp Phe Leu 
    770                 775                 780                 


Lys Lys Pro Glu Val Asn Asn Asn Gly Met Ala Lys Thr Ile Ile Asn 
785                 790                 795                 800 


Asp Phe Tyr Met Arg His Glu Gln Phe Met His Lys Leu Asn Val Gln 
                805                 810                 815     


Ile Asn Asp Ser Thr Ser Lys Gln Glu Leu Glu Asp Lys Tyr Lys Ala 
            820                 825                 830         


Gln Lys Lys Leu Leu Asn Arg Phe Gln Met Asn Pro Glu Ala Ala Thr 
        835                 840                 845             


Ile Leu Lys Lys Tyr Glu Glu Leu Lys Ala Ile Glu Asn Ile Asn Gln 
    850                 855                 860                 


Ile Asp Leu Asp Leu Trp Gly Lys Ile Gly Asp Ile Glu Ile Ile Asp 
865                 870                 875                 880 


His Lys Lys His Lys Lys Ile Ser Asp Leu Lys Pro Leu Glu Arg Asn 
                885                 890                 895     


Leu Lys Gly Asp Leu Ile Ile Asp Lys Ile Asn Glu Met Ala Glu Leu 
            900                 905                 910         


Leu Phe Gly Ile Tyr Lys Arg Tyr Met Val Arg Asp Ile Lys Lys Ile 
        915                 920                 925             


Leu His Lys Gln Leu Thr Lys Asn Glu Ser Arg Tyr Ile Asn Leu Leu 
    930                 935                 940                 


Ile Tyr Asp Lys Met Asn Ser Glu Glu Ala Leu Arg Asn Lys Glu Ile 
945                 950                 955                 960 


Ile Tyr Thr Val His Met Lys Lys Asp Lys Glu Lys Trp Lys Ile Glu 
                965                 970                 975     


Asn Asp Glu Val Val Asn Glu Val Met Gln Leu His Asn Ile Glu Ile 
            980                 985                 990         


Ile Ser Asn Glu Lys Gly Leu Leu  Arg Cys Ile Pro Lys  Asn Glu Ala 
        995                 1000                 1005             


Ser Ile  Met Glu Leu Asp Ile  Asn Arg Ser Tyr Ile  Gln Lys Met 
    1010                 1015                 1020             


Lys Ile  Ile Val Ser Asn Asn  Ser Val Asp His Glu  
    1025                 1030                 1035 


<210>  2797
<211>  1035
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2797

Met Thr Asn Asn Lys Lys Pro Ala Asn Lys Asn Ser Ile Ile Arg Val 
1               5                   10                  15      


Ile Ile Ser Asn Phe Asp Glu Asn Ser Ile Lys Glu Ile Lys Val Leu 
            20                  25                  30          


Tyr Thr Lys Gln Gly Gly Val Asp Thr Ile His Ile Lys Lys Met Ser 
        35                  40                  45              


Met Cys Glu Glu Asp Lys Ser Leu Tyr Phe Glu Glu Val Glu Cys Asn 
    50                  55                  60                  


Ser Gln Phe Gly Asn Ile Asp Ile Lys Ile Glu Lys Asp Asn Arg Ser 
65                  70                  75                  80  


Val Ile Val Glu Lys Tyr Asp Lys Tyr Thr Gly Leu Ile Ile Arg Lys 
                85                  90                  95      


Tyr Lys Ile Phe Gly Thr Tyr Val Ile Thr Asn Lys Asn Ile Lys Leu 
            100                 105                 110         


Val Lys Val Tyr Val Gln Asp Ile Leu Asn Glu Lys Ser Thr Asn Lys 
        115                 120                 125             


Arg Arg Ile Glu Ser Tyr Thr Glu Arg Leu Leu Ile Asp Pro Ala Val 
    130                 135                 140                 


Ile Asn Asp Tyr Lys Lys Ile Met Glu Asn Asn Gln Asp Ile Asp Ser 
145                 150                 155                 160 


Lys Asn Ile Tyr Lys Leu Asn Arg Phe Ile Asn Tyr Arg Ser Asn Met 
                165                 170                 175     


Met Leu Tyr Phe Thr Phe Val Tyr Arg Phe Leu Gly Met Glu Leu Gly 
            180                 185                 190         


Thr Asn Gly Glu Val Tyr Lys Leu Asp Gln Glu Cys Asn Leu Glu Lys 
        195                 200                 205             


Gln Lys Lys Val Val Asp Tyr Val Ala Ser Asn Ile Glu Lys Phe Val 
    210                 215                 220                 


Glu Asn His Asn Asn Tyr Ala Gln Lys Arg Asn Glu Glu Thr Glu Glu 
225                 230                 235                 240 


Lys Lys Leu His Arg Asp Lys Glu Ile Leu Ile Glu Ile Asp Lys Lys 
                245                 250                 255     


Leu Leu Glu Lys Asp Ile Lys Asn Ile Ile Thr Ile Val Ala Ser Val 
            260                 265                 270         


Arg His Lys Leu Ala His Tyr Asn Tyr Thr Phe Phe Gln Asp Leu Leu 
        275                 280                 285             


Glu Gly Lys Glu Ile Val Leu Glu Lys Gln Lys Pro Leu Asn Glu Leu 
    290                 295                 300                 


Leu Asp Leu Asn Ile Phe Lys Glu Ile Gly Lys Ile Lys Asn Leu Lys 
305                 310                 315                 320 


Glu Glu Lys Ala Thr Thr Tyr Leu Glu Asp Asp Thr Lys Val Tyr Val 
                325                 330                 335     


Leu Gly Lys His Lys Lys Ala Lys Lys Leu Tyr Asn Tyr Tyr Asp Lys 
            340                 345                 350         


Leu Cys Thr Arg Lys Asp Gly Phe Asn Asn Phe Ile Asn Ser Phe Phe 
        355                 360                 365             


Ser Val Asp Gly Asn Glu Asn Pro Asp Phe Lys Lys His Ile Asn Glu 
    370                 375                 380                 


His Phe Glu Lys Arg Ile Asp Glu Leu Asn Tyr Gln Val Asn Asn Thr 
385                 390                 395                 400 


Lys Lys Val Arg Glu Asp Ile Lys Arg Glu Leu Val Glu Met Gln Glu 
                405                 410                 415     


Ile Lys Lys Leu Ile Gly Glu Ala Tyr Ile Trp Asp Ile His Gln Cys 
            420                 425                 430         


Lys Glu Tyr Lys Arg Ile Tyr Asn Lys Arg Lys Asn Leu Val Glu Glu 
        435                 440                 445             


Val Ser Gln Leu Ser Arg Lys Ala Asn Arg Asp Lys Val Asp Lys Asp 
    450                 455                 460                 


Lys Ile Ser Lys Leu Asn Asn Glu Ile Leu Lys Met Asn Thr Gln Met 
465                 470                 475                 480 


Glu Lys Tyr Thr Lys Leu Asn Ser Lys Phe Arg Leu Gln Tyr Lys Leu 
                485                 490                 495     


Gln Met Ala Tyr Gly Phe Leu Tyr Glu Glu Tyr Gly Phe Asp Leu Lys 
            500                 505                 510         


Arg Phe Gly Asp Arg Phe Asn Ser Ser Ile Leu Asp Glu Leu Lys Pro 
        515                 520                 525             


Tyr Lys Glu Asn Gly Leu Lys Tyr Leu Lys Thr Lys Val Thr Ser Asn 
    530                 535                 540                 


Asp Asn Ile Gly Phe Ser Leu Gly Glu Phe Glu Lys Lys Ile Asn Ala 
545                 550                 555                 560 


Met Lys Ala Met Asp Asn Gly Leu Phe Asn Pro Thr His Ser Asn Asn 
                565                 570                 575     


Leu Phe Lys Trp Tyr Val Leu Met Tyr Ile Leu Leu Pro Thr Glu Ile 
            580                 585                 590         


Arg Gly Asp Phe Leu Gly Phe Val Lys Asn Gln Tyr Tyr Glu Leu Lys 
        595                 600                 605             


His Val Asp Tyr Ile Glu Asp Gln Val Ile Glu Lys Asp Leu Phe Phe 
    610                 615                 620                 


His Arg Met Arg Leu Phe Glu Lys Asn Thr Lys Lys Leu Ser Phe Ile 
625                 630                 635                 640 


Ser Tyr Gly Ile Asp Ser Leu Phe Asp Ile Lys Glu Tyr Phe Asn Tyr 
                645                 650                 655     


Leu Leu Pro Gln Leu Asn Pro Met Glu Met Asp Asp His Phe Val Asn 
            660                 665                 670         


Asn Phe Thr Arg Ser Met Val Leu Pro Met Leu Lys Tyr Tyr Gln Asn 
        675                 680                 685             


Ile Phe Lys Leu Leu Asn Asp Leu Glu Val Ala Ser Leu Ile Lys Tyr 
    690                 695                 700                 


Ser Asn Val Asn Asn Ile His Leu Leu Ser Glu Ala Ile Ala Asn Glu 
705                 710                 715                 720 


Lys Leu Lys Lys Asn Gly Asn Tyr Asn Phe Asn Thr Met Leu Gln Glu 
                725                 730                 735     


Thr Tyr Cys Ile Asp Ala Lys Cys Gly Trp Glu Leu Ser Arg Leu Arg 
            740                 745                 750         


Asn Glu Ile Ala His Leu Asn Ile Asp Arg Leu Phe Ile Glu Ile Pro 
        755                 760                 765             


Lys Asn Asp Glu Leu Asp Arg Asp Ile Asp Lys Leu Ile Asp Phe Leu 
    770                 775                 780                 


Lys Lys Pro Glu Val Asn Asn Asn Gly Met Ala Lys Thr Ile Ile Asn 
785                 790                 795                 800 


Asp Phe Tyr Met Arg His Glu Gln Phe Met His Lys Leu Asn Val Gln 
                805                 810                 815     


Ile Asn Asp Ser Thr Ser Lys Gln Glu Leu Glu Asp Lys Tyr Lys Ala 
            820                 825                 830         


Gln Lys Lys Leu Leu Asn Arg Phe Gln Met Asn Pro Glu Ala Ala Thr 
        835                 840                 845             


Ile Leu Lys Lys Tyr Glu Glu Leu Lys Ala Ile Glu Asn Ile Asn Gln 
    850                 855                 860                 


Ile Asp Leu Asp Leu Trp Gly Lys Ile Gly Asp Ile Glu Ile Ile Asp 
865                 870                 875                 880 


His Lys Lys His Lys Lys Ile Ser Asp Leu Lys Pro Leu Glu Arg Asn 
                885                 890                 895     


Leu Lys Gly Asp Leu Ile Ile Asp Lys Ile Asn Glu Met Ala Glu Leu 
            900                 905                 910         


Leu Phe Gly Ile Tyr Lys Arg Tyr Met Val Arg Asp Ile Lys Lys Ile 
        915                 920                 925             


Leu His Lys Gln Leu Thr Lys Asn Glu Ser Arg Tyr Ile Asn Leu Leu 
    930                 935                 940                 


Ile Tyr Asp Lys Met Asn Ser Glu Glu Ala Leu Arg Asn Lys Glu Ile 
945                 950                 955                 960 


Ile Tyr Thr Val His Met Lys Lys Asp Lys Glu Lys Trp Lys Ile Glu 
                965                 970                 975     


Asn Asp Glu Val Val Asn Glu Val Met Gln Leu His Asn Ile Glu Ile 
            980                 985                 990         


Ile Ser Asn Glu Lys Gly Leu Leu  Arg Cys Ile Pro Lys  Asn Glu Ala 
        995                 1000                 1005             


Ser Ile  Met Glu Leu Asp Ile  Asn Arg Ser Tyr Ile  Gln Lys Met 
    1010                 1015                 1020             


Lys Ile  Ile Val Ser Asn Asn  Ser Val Asp His Glu  
    1025                 1030                 1035 


<210>  2798
<211>  1023
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2798

Met Gly Glu Glu Lys Lys Asp Ser Tyr Gly Thr Lys Lys Lys Ser Trp 
1               5                   10                  15      


Pro Lys Cys Tyr Gly Leu Lys Ser Val Leu Asp Tyr Gln Gly His Ile 
            20                  25                  30          


Val Val Thr Ser Val Ala Lys Glu Ala Asp Thr Ala Lys Asn Glu Thr 
        35                  40                  45              


Gly Gly Phe Asp Gln Glu Thr Gln Pro Asp Cys Thr Leu Ile Arg Gly 
    50                  55                  60                  


Val Asp Asp Met Glu Phe Ser Leu Ala Asp Gly Glu Lys Lys Ile Lys 
65                  70                  75                  80  


Val Lys Ala Lys Asp Ala Lys Gln Asp Phe Leu Val Glu Lys Pro Phe 
                85                  90                  95      


Ser Tyr Ala Lys Thr Glu Asp Gly Ala Pro Lys Leu Ser Pro Lys Glu 
            100                 105                 110         


Asp Tyr Leu Gly Ile Ala Lys Tyr Ile Cys His Asp Ile Phe Gly Gln 
        115                 120                 125             


Pro Leu Glu Glu Arg Tyr Asp Asp Asn Ile His Tyr Gln Ile Ala Tyr 
    130                 135                 140                 


Asn Ile Ala Asp Leu Glu Lys Ile Ile Phe Tyr Glu Val Asn Asp Ala 
145                 150                 155                 160 


Cys Phe Ala Val Asp Asn Ile Leu Lys Ala Lys Asp Phe Asp Glu Ala 
                165                 170                 175     


Ala Ser Leu Arg Pro Ile Asp Arg Ser Thr Leu Ser Lys Glu Glu Val 
            180                 185                 190         


Lys Arg Ala Glu Met Glu Arg Asp Phe Ile Gly Glu Phe Asn Pro Lys 
        195                 200                 205             


Pro Thr Phe Asn Glu Glu Val Ala Phe Ala Ala Ser Lys Pro Thr Asp 
    210                 215                 220                 


Glu Asp Gly Lys Ala Lys Val Met Ala Ala Asn Val Gln Leu Asp Thr 
225                 230                 235                 240 


Phe Ala Arg Phe Asn Arg Leu Ala Glu Pro Tyr Ser Pro Phe Phe Asn 
                245                 250                 255     


Ser Leu Phe Ile Tyr Arg Asp Lys Lys Ile Glu Ser Arg Lys Gln Pro 
            260                 265                 270         


Gly Asp Asp Tyr Phe Ala Glu His Asn Tyr Asn Val Ile Arg Val Leu 
        275                 280                 285             


Ala Ser Leu Arg His Phe Phe Thr His Arg Thr Trp Gly Lys Ala Asp 
    290                 295                 300                 


Val Ala Asp Gly Glu Ala Ser Asp Thr Ser Phe Phe Asp Phe Ser His 
305                 310                 315                 320 


Glu Leu Val Asn Lys Tyr Lys Gly Val Ala Asp Phe Ala Ser Met Thr 
                325                 330                 335     


Phe Ala Asn Lys Ala Asn Glu Leu Asn Glu Ser Phe Ala Asn Thr Cys 
            340                 345                 350         


Ala Thr Asp Leu Val Ile Leu Cys Ala Tyr Phe Gly Thr Asp Thr Lys 
        355                 360                 365             


Asp Glu Ala Gly Val Arg Lys His Leu Arg Ser Tyr Tyr Asp Phe Val 
    370                 375                 380                 


Val Gly Glu Ser Ala Lys Asn Ile Gly Ile Asn Met Thr Lys Val Arg 
385                 390                 395                 400 


Glu Lys Met Ile Asp Ala His Tyr Gly Glu Gly Ser Asp Asn Asn Leu 
                405                 410                 415     


Arg Ser Lys Glu His Asp Ser Tyr Arg Gly Arg Leu Tyr Arg Leu Phe 
            420                 425                 430         


Ser Tyr Val Leu Phe Leu Asp Val Glu Ser Asp Pro Thr Lys Phe Val 
        435                 440                 445             


Asp Pro Asn Val Ala Lys Leu Arg Leu Ala Arg Thr Asp Glu Asp Lys 
    450                 455                 460                 


Gly Ala Ile Tyr Ala Gln Met Ala Glu Asp Cys Phe Gln Ala Phe Lys 
465                 470                 475                 480 


Asp Asp Phe Ser Glu Met Ile Arg Leu Val Arg Glu Asn Val Arg Ile 
                485                 490                 495     


Asn Gly Glu Lys Ser Lys Gln Lys Phe Pro Phe Ala Ile Thr Val Glu 
            500                 505                 510         


Asn Pro Leu Leu Gly Asp Glu Glu Thr Leu Ile Phe Val Gln Met Val 
        515                 520                 525             


Phe Phe Leu Ser Leu Phe Leu Gly Glu Lys Glu Ser Asn Asp Leu Leu 
    530                 535                 540                 


Thr Ser Leu Ser Asn Lys Phe Asp Asn Ile Val Gln Phe Met Lys Val 
545                 550                 555                 560 


Leu Val Phe Leu Asp Pro Glu His Lys Gln Val His Ile Asn Gly Lys 
                565                 570                 575     


Tyr Ser Leu Phe Arg Val Glu Asn Ala Glu Lys Ile Ala Thr Gln Leu 
            580                 585                 590         


Arg Val Ala Gln Lys Val Ser Arg Met Arg Lys Asn Leu Lys Lys Ala 
        595                 600                 605             


Asp Val Ser Ala Ser Leu Leu Gly Glu Ala Met Asn Val Phe Ser Arg 
    610                 615                 620                 


His Asp Phe Tyr Ala Pro Asp Asp Val Gly Ala Asp Gly Lys Val Val 
625                 630                 635                 640 


Arg Asp Pro Arg Leu Ala Lys Met Leu Asp Asp Thr Phe Asn Ser Lys 
                645                 650                 655     


Lys Gly Ser Asp Asp Arg Thr Phe Arg Asn Phe Leu Leu Asn Asn Val 
            660                 665                 670         


Leu Ala Ser Arg Arg Phe Ala Tyr Ile Ile Arg Tyr Phe Asp Ala Arg 
        675                 680                 685             


Gly Val Arg Arg Leu Met Asp Ala Asp Ser Ala Val Arg Phe Val Leu 
    690                 695                 700                 


Gly Thr Ile Pro Glu Thr Gln Ile Arg Arg Tyr Tyr Gly Val Met Ala 
705                 710                 715                 720 


Gln Asn Pro Ala Pro Leu Pro Gln Met Ile Asp Phe Leu Ala Ser Gln 
                725                 730                 735     


Met Lys Leu Leu Asp Ile Asp Phe Leu Leu Gly Lys Lys Gly Ala Met 
            740                 745                 750         


Gln Gln Trp Ala Lys Ser Val Gly Arg Val Pro Ala Asp Lys Gln Val 
        755                 760                 765             


Phe Leu Thr Gln Val Gly Leu Tyr Leu Thr Val Ala Tyr Leu Ile Val 
    770                 775                 780                 


Lys Asn Val Val Asn Ala Asn Ala Arg Phe Ser Ser Ala Phe Ala Ser 
785                 790                 795                 800 


Tyr Glu Cys Asp Arg Ser Leu Tyr Ala Lys Ser Met Gly Glu Lys Ala 
                805                 810                 815     


Val Ser Lys Ala Gly Gly Asp Leu Asn Ser Tyr Asp Ala Asp Leu Thr 
            820                 825                 830         


Arg Phe Phe Ile Gly Gln Leu Pro Gly Lys Asp Ala Asp Gly Asn Asp 
        835                 840                 845             


Ala Leu Val Gly Leu Asn Lys Tyr Tyr Phe Lys Ser Gln Arg Tyr Leu 
    850                 855                 860                 


Leu Asp Tyr Cys Arg Tyr Phe Glu Arg Leu Glu Lys Glu Cys Asn Ile 
865                 870                 875                 880 


Asp Lys Leu Ser Val Gly Lys Leu Tyr Arg Asn His Val Val His Leu 
                885                 890                 895     


Asn Tyr Ile Ala Gly Leu Ala Asn Ile Lys Glu Ile Glu His Val Arg 
            900                 905                 910         


Ser Tyr Tyr Asp Ile Tyr Val Tyr Leu Val Glu Lys Gly Met Val Thr 
        915                 920                 925             


Ser Phe Glu Asp Pro Ala Thr Lys Ala Ile Val Leu Ala Ser Val Pro 
    930                 935                 940                 


Ser Asp Gly Ala Asp Lys Pro Ala Asp Lys Ser Leu Leu Ala Asp Leu 
945                 950                 955                 960 


Lys Phe Ser Leu Asp Lys Tyr His Ser Tyr Ser Trp Met Phe Phe Lys 
                965                 970                 975     


Trp Leu Asn Ala Met Phe Gly Tyr Cys Leu Pro Arg Phe Gln Asn Leu 
            980                 985                 990         


Thr Thr Ala Asn Leu Phe Asn Glu  Arg Asp Tyr Gly Arg  Ser Val Ile 
        995                 1000                 1005             


Lys Arg  Pro Glu Pro Lys Ser  Gln Phe Asp Ala Ala  Lys Ala Lys 
    1010                 1015                 1020             


<210>  2799
<211>  946
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2799

Met Lys Lys Phe Ser Asn Ile Lys Arg Leu Gly Val Lys Ser Val His 
1               5                   10                  15      


Tyr Ala Asn Asn Thr Val Ile Val Glu Asp His Phe Ser Lys Asn Thr 
            20                  25                  30          


Asn Ile Leu Phe Thr Ala Glu Tyr Glu Asn Ile Asp Asp Leu Lys Ser 
        35                  40                  45              


Cys Thr Asn Ile Asp Lys Thr Ala Glu Asn Lys Gly Val Arg Phe Thr 
    50                  55                  60                  


Asp Leu Lys Asn Lys Asn Gly Phe Glu Leu Ser Ala Met Ala Gln Lys 
65                  70                  75                  80  


Gln Ile Leu Lys Ser Arg Val Asn Arg Val Lys Lys Val Ser Tyr Thr 
                85                  90                  95      


Gln Glu Leu Phe Asp Ile Thr Thr Asp Asn Asn Ile Glu Val Gln Ile 
            100                 105                 110         


Phe Ser Asn Leu Glu Asp Val Lys Lys Val Ile Ala Pro Tyr Tyr Asn 
        115                 120                 125             


Asn Val Ala Tyr Ala Ile Asn Ser Leu Tyr Arg Asp Ile Ser Asn Asp 
    130                 135                 140                 


Asp Ser Tyr Gly Phe Asp Lys Ile Gly Ser Ile Pro Val Asp Ala Asp 
145                 150                 155                 160 


Trp Tyr Asn Phe Leu Lys Asp Ala Pro Asp Lys Lys Glu Lys Trp Thr 
                165                 170                 175     


Thr Tyr Ile Ile Pro Ser Tyr Lys Lys Val Ile Ala Arg Phe Gly Ile 
            180                 185                 190         


Gln Met Glu Lys Asn Gln Gln Val Asn Phe Cys Lys Cys Leu Glu Tyr 
        195                 200                 205             


Val Ala Ile Arg Asn Gly Leu Phe Val Lys Phe Lys Asp Glu Lys Val 
    210                 215                 220                 


Asp Pro Asp Lys Leu Leu Asn Lys Lys Ile Gln Glu Lys Leu Asp Lys 
225                 230                 235                 240 


Leu Ile Ser Asp Lys Glu Val Asn Asp Lys Leu Phe Glu Leu Ala Lys 
                245                 250                 255     


Thr Pro Val Ser Glu Phe Cys Ala Glu Ala Asn Ala Ile Pro Leu Tyr 
            260                 265                 270         


Arg Tyr Ala Phe Ile Gly Gln Lys Gly Lys Arg Ile Glu Lys Ile Val 
        275                 280                 285             


Leu Asp Lys Leu Glu Glu Asn Glu Ile Leu Ser Ser Leu Val Arg Lys 
    290                 295                 300                 


Ile Asp Glu Asn Glu Thr Thr Tyr Asn Tyr Leu Arg Leu Leu Ser Ala 
305                 310                 315                 320 


Ile Arg Gln Tyr Val Val His Asn Ser Arg Lys Val Arg Ile Asp Lys 
                325                 330                 335     


Asn Val Phe Ile Asn Asp Thr Ala Lys Arg Asp Val Glu Glu Phe Ala 
            340                 345                 350         


Lys Gln Phe Gln Lys Asn Asn Tyr Lys Tyr Phe Cys Ile Leu Lys Glu 
        355                 360                 365             


Leu Tyr Ser Asp Ser Asp Ile Leu Glu Gln Phe Phe Asp Tyr Thr Val 
    370                 375                 380                 


Phe Asp Glu Ala Arg Asn Leu Lys Ile Ser Ile Asp Lys Ile Lys Lys 
385                 390                 395                 400 


Gly Ile Thr Ala Asn Ile Asp Ile Ser Ala Asp Val Glu Pro Asp Lys 
                405                 410                 415     


Leu Ser Glu Tyr Ala Asn Lys Phe Arg Thr Val Thr Met Phe Ala Leu 
            420                 425                 430         


Thr Lys Tyr Leu Lys Glu Asn Val Gly Glu Ile Glu Asp Phe Leu Ala 
        435                 440                 445             


Asn Ile Lys Val Cys Ser Ser Asp Glu Glu Lys Ala Gly Val Tyr Glu 
    450                 455                 460                 


Gln Lys Ala Lys Glu Phe Ile Thr Lys Phe Asp Ser Phe Lys Asp Ile 
465                 470                 475                 480 


Arg Ser Val Val Lys Lys His Leu Gly Thr Gln Lys Val Asn Glu Lys 
                485                 490                 495     


Phe Asp Phe Tyr Pro Ser Asp Ile Asn Phe Gly Arg Asp Ser Asn Val 
            500                 505                 510         


Phe Phe Asn Met Leu Tyr Val Met Ser Lys Phe Leu Thr Val Asn Glu 
        515                 520                 525             


Ala Arg Ile Met Phe Gln Lys Ile Lys Ser Lys Tyr Asp Ser Val Lys 
    530                 535                 540                 


Ser Leu Leu Lys Ile Ala Glu Leu Thr Gly Val Thr Leu Ser Asp Asn 
545                 550                 555                 560 


Leu Phe Asp Arg Phe Arg Met Ile Phe Asp Lys Glu Arg Val Asp Glu 
                565                 570                 575     


Tyr Gln Lys Gln Leu Ile Val Leu Gln Ser Ile Arg Thr Arg Asn Gly 
            580                 585                 590         


Val Ser Gln Glu Gly Phe Ala Lys Glu Leu Lys Arg Ile Phe Asp Met 
        595                 600                 605             


Phe Lys Lys Asp Asp Ile Ser Tyr Glu Glu Phe Glu Lys Glu Leu Ser 
    610                 615                 620                 


Leu Asp Glu Asn Gln Asn Glu Ile Lys Asn Lys Ser Phe Lys Leu Lys 
625                 630                 635                 640 


Pro Leu Lys Ser Tyr Leu Arg Asn Asp Val Tyr Lys Ser Lys Gln Tyr 
                645                 650                 655     


Gln Tyr Ile Ser Ser Phe Ala Ser Ala Gly Ile Cys Gln Lys Ile Met 
            660                 665                 670         


Glu Asn Lys Asp Ile Val Ala Phe Val Leu Asn Gly Met Leu Tyr Gln 
        675                 680                 685             


Glu Gly Lys Leu Ser Met Pro Met His Lys Tyr Val Ala Lys Val Tyr 
    690                 695                 700                 


His Asp Phe Arg Arg Glu Lys Ile Asp Glu Asn Ser Ala Asn Tyr Leu 
705                 710                 715                 720 


Leu Asp Gln Asn Gln Ile Ser Ser Leu Val Asn Ser Leu Cys Asp Leu 
                725                 730                 735     


Lys Leu Glu Asn Ile Ile Glu Ala Ile Phe Lys Glu Ser Arg Val Asn 
            740                 745                 750         


Tyr Lys Ala Leu Val Arg Leu Tyr Leu Asn Ile Cys Tyr Leu Phe Val 
        755                 760                 765             


Lys Asn Ile Ile Ser Leu Asn Ser Thr Tyr Leu Ile Gln Phe Gln Asp 
    770                 775                 780                 


Tyr Glu Asn Ile Tyr Lys Gln Leu His Leu Glu Asp Leu Met Asp Ile 
785                 790                 795                 800 


Thr Tyr Asp Phe Gly Val Leu Asn Asn Phe Val Glu Asn Ala Pro Asn 
                805                 810                 815     


Lys Lys Cys Arg Ser Tyr Met Gln Leu Gln Thr Leu Leu Glu Lys Asp 
            820                 825                 830         


Tyr Ile Lys Asp Tyr Ile Tyr Thr Pro Glu Tyr Gln Val Leu Gln Asp 
        835                 840                 845             


Arg Tyr Arg Asn Leu Val Val His Ser Ser Leu Leu Phe Gly Leu Asp 
    850                 855                 860                 


Lys Ile Asp Phe Asp Phe Gly Glu Val Gln Asn Ile Ser Ser Tyr Phe 
865                 870                 875                 880 


Ala Ile Tyr Gln Thr Leu Val Gln Arg Leu Val Glu Gln Asp Ala Arg 
                885                 890                 895     


Glu Val Trp Gly Glu Lys Phe Asp Glu Tyr Phe Ala Leu Asn Asn Gly 
            900                 905                 910         


Lys Thr Tyr Ser Thr Lys Leu Cys Ile Ala Leu Asn Met Pro Tyr Ala 
        915                 920                 925             


Tyr Asn Ile Ser Arg Phe Asn Asn Asn Thr Ile Glu Lys Tyr Ser Asn 
    930                 935                 940                 


Lys Arg 
945     


<210>  2800
<211>  960
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2800

Met Ala Lys Lys Leu Asn Ala Lys Glu Lys Arg Leu Leu Ser Gln Gln 
1               5                   10                  15      


Ala Gln Lys Asp Lys Tyr Lys Lys Met Glu Glu Glu Arg Gln Ala Ala 
            20                  25                  30          


Glu Gln Ala Arg Leu Ala Glu Glu Ala Arg Gln Lys Ala Glu Thr Glu 
        35                  40                  45              


Arg Lys Lys Lys Glu Ala Leu Glu Lys Glu Ala Arg Glu Lys Leu Glu 
    50                  55                  60                  


Lys Glu Leu Leu Glu Lys Asn Pro Ser Leu Lys Lys Val Lys Lys Ser 
65                  70                  75                  80  


Lys Ala Lys Ala Ala Gly Leu Lys Ser Thr Phe Ala Ile Gly Asn Glu 
                85                  90                  95      


Leu Leu Met Thr Ser Phe Gly Lys Gly Asn Glu Ala Val Pro Glu His 
            100                 105                 110         


Tyr Ile Phe Glu Asn Gly Met Ile Ser Met Gln Asn Pro Pro Ala Phe 
        115                 120                 125             


Asp Val Glu Asn Arg Gly Thr Ser Phe Ser Ile Ala Gly Lys Asn Ala 
    130                 135                 140                 


Met Asn Ala Ile Ala Asp Asp Pro Arg Arg Thr Ser Lys Lys Val Ile 
145                 150                 155                 160 


Gly Glu Asp Leu Ile Gly Ala Lys Ser Ala Leu Glu Lys Arg Tyr Phe 
                165                 170                 175     


Gly Lys Thr Phe Glu Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
            180                 185                 190         


Leu Asp Ile Glu Lys Ile Leu Ser Lys His Ile Asn Asn Ile Val Phe 
        195                 200                 205             


Ser Ile Asn Asn Ile Arg Gly Ile Ala Asp Pro Glu Arg Asp Asp Leu 
    210                 215                 220                 


Ile Gly Tyr Met Ser Leu Arg Asp Ser Tyr Glu Tyr Phe Met Asp Glu 
225                 230                 235                 240 


Lys Asn Glu Lys Arg Lys Val Leu Arg Glu Ser Tyr Arg Lys Leu Phe 
                245                 250                 255     


Lys Ser Ser Arg Leu Ser Tyr Phe Gly Ser Ala Phe Tyr Val Glu Lys 
            260                 265                 270         


Gln Ser Thr Gln Lys Lys Lys Ser Gly Gln Lys Asn Phe Glu Leu Arg 
        275                 280                 285             


Asn Glu Lys Asp Cys Tyr Tyr Met Leu Ala Leu Leu Gly Glu Leu Arg 
    290                 295                 300                 


Gln Val Leu Ala His Ser Ser Ala Gln Lys Gln Gly Lys Glu Gln Thr 
305                 310                 315                 320 


Glu Ala Arg Ser Ser Val Tyr Asn Leu Arg Thr Val Gly Asn Asn Asp 
                325                 330                 335     


Met Arg Lys Ile Leu Asn Ser Leu Tyr Ala Glu Arg Val Asp Ala Leu 
            340                 345                 350         


Asn Glu Asn Phe Met Asn Tyr Ala Lys Lys Asp Leu Thr Ile Leu Phe 
        355                 360                 365             


Gly Ile Met Asp Ala Ser Ser Tyr Glu Lys Lys Ala Glu Ile Ala Arg 
    370                 375                 380                 


Asp Phe Tyr Asp Phe Thr Val Arg Lys Ser Tyr Lys Asn Ile Gly Phe 
385                 390                 395                 400 


Ser Ile Lys Lys Ile Arg Glu Arg Met Met Asp Cys Phe Phe Ala Asn 
                405                 410                 415     


Val Lys Glu Ile Thr Pro Asp Ser Pro Asp Phe Gln Ser Val Arg Gln 
            420                 425                 430         


Lys Phe Tyr Lys Ile Leu Asp Phe Leu Leu Phe Thr Tyr Tyr Lys Asp 
        435                 440                 445             


Asn Lys Glu Glu Thr Lys Lys Ile Ile Ala Ala Leu Arg Ala Ser Leu 
    450                 455                 460                 


Thr Glu Leu Glu Lys Glu Leu Phe Tyr Gln Lys Gln Ala Asn Ile Leu 
465                 470                 475                 480 


Trp Asn Lys Met Gln Met Val Val Thr Glu Gln Ile Tyr Pro Arg Thr 
                485                 490                 495     


Lys Gly Ser Ala Ile Gln Asn Leu Ile Ala Asp Pro Glu Ile Ser Ala 
            500                 505                 510         


Asp Met Leu Lys Gly Val Met Ile Thr Pro Glu Ser Val Asp Tyr Phe 
        515                 520                 525             


Ser Lys Met Ile Tyr Leu Leu Thr Leu Phe Ile Asp Gly Lys Glu Ile 
    530                 535                 540                 


Asn Asp Leu Leu Thr Thr Met Ile Asn Lys Phe Glu Asn Ile Ala Ser 
545                 550                 555                 560 


Phe Val Ser Val Leu Lys Asp Arg Gly Leu Pro Cys Asn Phe Arg Asn 
                565                 570                 575     


Asp Tyr Ser Val Phe Asn Asn Ala Leu Lys Ile Ser Ala Glu Leu Arg 
            580                 585                 590         


Glu Ile Asn Ser Phe Ala Arg Met Glu Lys Ala Thr Pro Gly Ala Lys 
        595                 600                 605             


Lys Gln Met Phe Leu Asp Ala Ala Ile Ile Leu Gly Ser Asn Glu Ser 
    610                 615                 620                 


Ala Glu Glu Leu Ser Glu Tyr Phe Asp Glu Met Leu Asp Lys Gln Lys 
625                 630                 635                 640 


Gly Lys Arg Thr Pro Gly Gly Lys Lys Asp Met Gly Phe Arg Asn Phe 
                645                 650                 655     


Leu Ile Lys Asn Val Ile Glu Ser Asp Arg Phe His Tyr Leu Ile Arg 
            660                 665                 670         


Tyr Gly His Pro Leu His Ile Arg Lys Leu Ala Glu Asn Lys Asn Val 
        675                 680                 685             


Ile Ala Phe Val Leu Lys Gln Ile Pro Glu Pro Gln Ile Asp Arg Tyr 
    690                 695                 700                 


Cys Lys Ile Cys Ala Leu Pro Ala Glu Ser Asn Phe Ala Gln Lys Ile 
705                 710                 715                 720 


Leu Arg Leu Thr Asp Leu Ile Ala Glu Met Asn Phe Arg Gln Phe Glu 
                725                 730                 735     


Asn Val Arg Gln Thr Glu Lys Asn Glu Gln Lys Gln Ile Leu Gln Gly 
            740                 745                 750         


Ile Leu Ser Leu Tyr Leu Thr Val Leu Tyr Leu Leu Thr Lys Asn Leu 
        755                 760                 765             


Val Tyr Val Asn Ser Arg Tyr Phe Leu Ala Phe His Cys Leu Glu Arg 
    770                 775                 780                 


Asp Thr Glu Leu Leu Gly Ser Gln Ala Gly His Lys Asn Ala Glu Lys 
785                 790                 795                 800 


Gln Leu Ile Ala Ser Tyr Ser Ala Leu Thr Gln Gln Phe Leu Asp Glu 
                805                 810                 815     


Gly Lys Leu Asn Arg His Ala Arg Glu Tyr Leu Thr Val Asn Ile Gln 
            820                 825                 830         


Asn Ser Asp Asp Trp Thr Ile Ala Gln Tyr Arg Asn Asn Ala Ala His 
        835                 840                 845             


Leu Asn Ala Ile Arg Asn Ala His Leu Tyr Ile Arg Glu Met Lys Ser 
    850                 855                 860                 


Val Arg Ser Tyr Phe Glu Leu Tyr His Tyr Leu Thr Gln Arg Ala Leu 
865                 870                 875                 880 


Leu Asp Lys Tyr Glu Asn Val Pro Tyr His Pro Gln Val Asn Glu Lys 
                885                 890                 895     


Thr Leu Lys Tyr Phe Glu Leu Leu Lys Glu Asn Gly Trp Tyr Cys Lys 
            900                 905                 910         


Asp Phe Val Lys Ala Leu Asn Val Pro Phe Gly Tyr Asn Leu Pro Arg 
        915                 920                 925             


Tyr Lys Asn Leu Ser Ile Asp Ala Leu Phe Asp Lys Asp Arg Pro Gln 
    930                 935                 940                 


Glu Glu Asp Glu Asn His Leu Tyr Thr Cys Gln Asn Ile Lys Lys Ser 
945                 950                 955                 960 


<210>  2801
<211>  946
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2801

Met Lys Lys Phe Ser Asn Ile Lys Arg Leu Gly Val Lys Ser Val His 
1               5                   10                  15      


Tyr Ala Asn Asn Thr Val Ile Val Glu Asp His Phe Ser Lys Asn Thr 
            20                  25                  30          


Asn Ile Leu Phe Thr Ala Glu Tyr Glu Asn Ile Asp Asp Leu Lys Ser 
        35                  40                  45              


Cys Thr Asn Ile Asp Lys Thr Ala Glu Asn Lys Gly Val Arg Phe Thr 
    50                  55                  60                  


Asp Leu Lys Asn Lys Asn Gly Phe Glu Leu Ser Ala Met Ala Gln Lys 
65                  70                  75                  80  


Gln Ile Leu Lys Ser Arg Val Asn Arg Val Lys Lys Val Ser Tyr Thr 
                85                  90                  95      


Gln Glu Leu Phe Asp Ile Thr Thr Asp Asn Asn Ile Glu Val Gln Ile 
            100                 105                 110         


Phe Ser Asn Leu Glu Asp Val Lys Lys Val Ile Ala Pro Tyr Tyr Asn 
        115                 120                 125             


Asn Val Ala Tyr Ala Ile Asn Ser Leu Tyr Arg Asp Ile Ser Asn Asp 
    130                 135                 140                 


Asp Ser Tyr Gly Phe Asp Lys Ile Gly Ser Ile Pro Val Asp Ala Asp 
145                 150                 155                 160 


Trp Tyr Asn Phe Leu Lys Asp Ala Pro Asp Lys Lys Glu Lys Trp Thr 
                165                 170                 175     


Thr Tyr Ile Ile Pro Ser Tyr Lys Lys Val Ile Ala Arg Phe Gly Ile 
            180                 185                 190         


Gln Met Glu Lys Asn Gln Gln Val Asn Phe Cys Lys Cys Leu Glu Tyr 
        195                 200                 205             


Val Ala Ile Arg Asn Gly Leu Phe Val Lys Phe Lys Asp Glu Lys Val 
    210                 215                 220                 


Asp Pro Asp Lys Leu Leu Asn Lys Lys Ile Gln Glu Lys Leu Asp Lys 
225                 230                 235                 240 


Leu Ile Ser Asp Lys Glu Val Asn Asp Lys Leu Phe Glu Leu Ala Lys 
                245                 250                 255     


Thr Pro Val Ser Glu Phe Cys Ala Glu Ala Asn Ala Ile Pro Leu Tyr 
            260                 265                 270         


Arg Tyr Ala Phe Ile Gly Gln Lys Gly Lys Arg Ile Glu Lys Ile Val 
        275                 280                 285             


Leu Asp Lys Leu Glu Glu Asn Glu Ile Leu Ser Ser Leu Val Arg Lys 
    290                 295                 300                 


Ile Asp Glu Asn Glu Thr Thr Tyr Asn Tyr Leu Arg Leu Leu Ser Ala 
305                 310                 315                 320 


Ile Arg Gln Tyr Val Val His Asn Ser Arg Lys Val Arg Ile Asp Lys 
                325                 330                 335     


Asn Val Phe Ile Asn Asp Thr Ala Lys Arg Asp Val Glu Glu Phe Ala 
            340                 345                 350         


Lys Gln Phe Gln Lys Asn Asn Tyr Lys Tyr Phe Cys Ile Leu Lys Glu 
        355                 360                 365             


Leu Tyr Ser Asp Ser Asp Ile Leu Glu Gln Phe Phe Asp Tyr Thr Val 
    370                 375                 380                 


Phe Asp Glu Ala Arg Asn Leu Lys Ile Ser Ile Asp Lys Ile Lys Lys 
385                 390                 395                 400 


Gly Ile Thr Ala Asn Ile Asp Ile Ser Ala Asp Val Glu Pro Asp Lys 
                405                 410                 415     


Leu Ser Glu Tyr Ala Asn Lys Phe Arg Thr Val Thr Met Phe Ala Leu 
            420                 425                 430         


Thr Lys Tyr Leu Lys Glu Asn Val Gly Glu Ile Glu Asp Phe Leu Ala 
        435                 440                 445             


Asn Ile Lys Val Cys Ser Ser Asp Glu Glu Lys Ala Gly Val Tyr Glu 
    450                 455                 460                 


Gln Lys Ala Lys Glu Phe Ile Thr Lys Phe Asp Ser Phe Lys Asp Ile 
465                 470                 475                 480 


Arg Ser Val Val Lys Lys His Leu Gly Thr Gln Lys Val Asn Glu Lys 
                485                 490                 495     


Phe Asp Phe Tyr Pro Ser Asp Ile Asn Phe Gly Arg Asp Ser Asn Val 
            500                 505                 510         


Phe Phe Asn Met Leu Tyr Val Met Ser Lys Phe Leu Thr Val Asn Glu 
        515                 520                 525             


Ala Arg Ile Met Phe Gln Lys Ile Lys Ser Lys Tyr Asp Ser Val Lys 
    530                 535                 540                 


Ser Leu Leu Lys Ile Ala Glu Leu Thr Gly Val Thr Leu Ser Asp Asn 
545                 550                 555                 560 


Leu Phe Asp Arg Phe Arg Met Ile Phe Asp Lys Glu Arg Val Asp Glu 
                565                 570                 575     


Tyr Gln Lys Gln Leu Ile Val Leu Gln Ser Ile Arg Thr Arg Asn Gly 
            580                 585                 590         


Val Ser Gln Glu Gly Phe Ala Lys Glu Leu Lys Arg Ile Phe Asp Met 
        595                 600                 605             


Phe Lys Lys Asp Asp Ile Ser Tyr Glu Glu Phe Glu Lys Glu Leu Ser 
    610                 615                 620                 


Leu Asp Glu Asn Gln Asn Glu Ile Lys Asn Lys Ser Phe Lys Leu Lys 
625                 630                 635                 640 


Pro Leu Lys Ser Tyr Leu Arg Asn Asp Val Tyr Lys Ser Lys Gln Tyr 
                645                 650                 655     


Gln Tyr Ile Ser Ser Phe Ala Ser Ala Gly Ile Cys Gln Lys Ile Met 
            660                 665                 670         


Glu Asn Lys Asp Ile Val Ala Phe Val Leu Asn Gly Met Leu Tyr Gln 
        675                 680                 685             


Glu Gly Lys Leu Ser Met Pro Met His Lys Tyr Val Ala Lys Val Tyr 
    690                 695                 700                 


His Asp Phe Arg Arg Glu Lys Ile Asp Glu Asn Ser Ala Asn Tyr Leu 
705                 710                 715                 720 


Leu Asp Gln Asn Gln Ile Ser Ser Leu Val Asn Ser Leu Cys Asp Leu 
                725                 730                 735     


Lys Leu Glu Asn Ile Ile Glu Ala Ile Phe Lys Glu Ser Arg Val Asn 
            740                 745                 750         


Tyr Lys Ala Leu Val Arg Leu Tyr Leu Asn Ile Cys Tyr Leu Phe Val 
        755                 760                 765             


Lys Asn Ile Ile Ser Leu Asn Ser Thr Tyr Leu Ile Gln Phe Gln Asp 
    770                 775                 780                 


Tyr Glu Asn Ile Tyr Lys Gln Leu His Leu Glu Asp Leu Met Asp Ile 
785                 790                 795                 800 


Thr Tyr Asp Phe Gly Val Leu Asn Asn Phe Val Glu Asn Ala Pro Asn 
                805                 810                 815     


Lys Lys Cys Arg Ser Tyr Met Gln Leu Gln Thr Leu Leu Glu Lys Asp 
            820                 825                 830         


Tyr Ile Lys Asp Tyr Ile Tyr Thr Pro Glu Tyr Gln Val Leu Gln Asp 
        835                 840                 845             


Arg Tyr Arg Asn Leu Val Val His Ser Ser Leu Leu Phe Gly Leu Asp 
    850                 855                 860                 


Lys Ile Asp Phe Asp Phe Gly Glu Val Gln Asn Ile Ser Ser Tyr Phe 
865                 870                 875                 880 


Ala Ile Tyr Gln Thr Leu Val Gln Arg Leu Val Glu Gln Asp Ala Arg 
                885                 890                 895     


Glu Val Trp Gly Glu Lys Phe Asp Glu Tyr Phe Ala Leu Asn Asn Gly 
            900                 905                 910         


Lys Thr Tyr Ser Thr Lys Leu Cys Ile Ala Leu Asn Met Pro Tyr Ala 
        915                 920                 925             


Tyr Asn Ile Ser Arg Phe Asn Asn Asn Thr Ile Glu Lys Tyr Ser Asn 
    930                 935                 940                 


Lys Arg 
945     


<210>  2802
<211>  1141
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2802

Met Gly Val Glu Lys Asn Lys Val Phe Glu Ser Val Ile Met Asn Phe 
1               5                   10                  15      


Asp Gln Glu Arg Lys Tyr Gly Phe Ile Glu Tyr Lys Glu Thr Asn Asn 
            20                  25                  30          


Leu Phe Phe His Met Glu Asn Val Lys Asn Pro Lys Glu Ile Val Lys 
        35                  40                  45              


Gly Ala Lys Val Arg Phe Glu Ile Tyr Glu Asn Pro Lys Pro Lys Lys 
    50                  55                  60                  


Gln Asn Gln Arg Phe Ser Ala Ile Asn Val Glu Val Ile Thr Asp Glu 
65                  70                  75                  80  


Thr His Lys Glu Ala Lys Ile Gln Lys Asn Glu Phe Lys Thr Phe Asp 
                85                  90                  95      


Gln Phe Thr Lys Glu Leu Gln Glu Thr Gln Lys Val Asn Gly Glu Thr 
            100                 105                 110         


Lys Lys Glu His Ile Thr Lys Asn Lys His Thr Asn Val Lys Ala Ala 
        115                 120                 125             


Gly Val Lys Ser Val Phe Ala Val Asp Asp Gly Asn Val Leu Ile Thr 
    130                 135                 140                 


Ser Phe Gly Arg Gly Asn Ala Ala Asp Ile Glu Thr Leu Lys Ser Asp 
145                 150                 155                 160 


Asp Asp Lys Thr Ile Asn Leu Thr Glu Thr Glu Asn Gln Lys Lys Tyr 
                165                 170                 175     


Val Val Thr Asn Lys Arg Ser Asn Val Lys Gly Leu Ala Asp Asn Pro 
            180                 185                 190         


Thr Lys Val Glu Ser Ile Ile Pro Gly Glu Thr Gln Ile Gly Phe Lys 
        195                 200                 205             


Ser Ile Leu Glu Lys His Phe Phe Gly Arg Thr Phe Asn Asp Asn Ile 
    210                 215                 220                 


His Ile Gln Ile Ile His Asn Ile Leu Asp Ile Lys Lys Ile Leu Ala 
225                 230                 235                 240 


Val His Thr Asn Asn Ile Val Tyr Ala Leu Asp Asn Ile His Glu Arg 
                245                 250                 255     


Gly Arg Glu Asn Ser Ala Glu Lys Pro Ile Asp Met Ile Gly Ala Gly 
            260                 265                 270         


Gly Ile Ser Thr Ser Lys Glu Tyr Glu Gln Tyr Cys Ser Glu Lys Ser 
        275                 280                 285             


Asp Tyr Glu Asp Asn Phe Leu Lys Gln Leu Ile Asn Asn Glu Arg Ile 
    290                 295                 300                 


Ala Tyr Phe Gly Asn Ala Phe Phe Lys Asp Glu Gly Asn Lys Lys Val 
305                 310                 315                 320 


Met Arg Thr Glu Lys Glu Ile Tyr Tyr Ile Leu Gly Met Leu Asn Glu 
                325                 330                 335     


Val Arg Asn Val Ser Thr His Phe Thr Glu Glu Asp Asn Arg Asp Trp 
            340                 345                 350         


Ala Lys Ala Asn Leu Tyr Asn Leu Ser Asn Arg Leu Lys Val Gly Ser 
        355                 360                 365             


Lys Glu Val Leu Asn Gln Leu Tyr Lys Glu Lys Ile Asp Lys Ile Asp 
    370                 375                 380                 


Ala Asn Gly Phe Val Asn Lys Gly Cys Lys Arg Asp Phe Ser Ile Leu 
385                 390                 395                 400 


Phe Lys Ser Leu Asn Leu Thr Thr Asp Lys Asp Lys Gly Glu Leu Val 
                405                 410                 415     


Val Gly Phe Tyr Asp Phe Ser Ile Arg Lys Asn Tyr Lys Asn Ile Gly 
            420                 425                 430         


Phe Ser Ile Lys Thr Leu Arg Glu Tyr Met Leu Lys Ile Ser Asn Ser 
        435                 440                 445             


Thr Leu Cys Ala Asp Thr Ile Ser Asn Asn Ala Ile Arg Pro Lys Ala 
    450                 455                 460                 


Tyr Lys Leu Tyr Asp Phe Ile Ile Trp His Tyr Tyr Met Asn Lys Pro 
465                 470                 475                 480 


Asp Lys Ile Asn Asp Phe Val Glu Lys Leu Arg Thr Gln Asn Lys Asn 
                485                 490                 495     


Asp Glu Lys Ile Lys Leu Tyr Tyr Asp Glu Ala Val Cys Leu Leu Ser 
            500                 505                 510         


Glu Leu Gly Arg Glu Ile His Thr Met Thr Ser Cys Val His Asn Ile 
        515                 520                 525             


Glu Asn Thr Ser Tyr Glu Ile Thr Asp Lys Lys Gln Lys Glu Tyr Tyr 
    530                 535                 540                 


Lys Met Gln Ile Asn Ser Leu Asn Ser Ala Asp Lys Val Ser Asp Phe 
545                 550                 555                 560 


Ser Lys Val Ile Tyr Leu Val Thr Leu Phe Leu Asp Gly Lys Glu Ile 
                565                 570                 575     


Asn Asp Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp Asn Ile Ala Ser 
            580                 585                 590         


Leu Leu Ser Val Leu Glu Lys Gln Ser Gly Lys Lys Val Glu Phe Val 
        595                 600                 605             


Glu Asn Tyr Ser Phe Phe Asn Ser Ser Asn Leu Leu Lys Glu Lys Thr 
    610                 615                 620                 


Leu Asn Lys Ser Glu Asn Tyr Thr Cys Lys Ile Val Glu Glu Leu Arg 
625                 630                 635                 640 


Glu Ile Asn Ser Phe Ala Arg Met Thr Gly Asp Cys Lys Ile Arg Lys 
                645                 650                 655     


Ser Ala Phe Glu Asp Ala Ser Gln Leu Leu Gly Tyr His Asp Lys Thr 
            660                 665                 670         


Val Asn Asn Leu Phe Glu Val Leu Arg Leu Lys Glu Leu Glu Ser Lys 
        675                 680                 685             


Asp Trp Lys Lys Arg Thr Asp Asp Glu Gln Gln Glu Tyr Asp Arg Leu 
    690                 695                 700                 


Leu Asn Lys His His Tyr Phe Lys Ser Gly Lys Lys Leu Pro Asp Thr 
705                 710                 715                 720 


Gly Leu Arg Asn Phe Ile Ile Asn Asn Val Ile Glu Ser Arg Arg Phe 
                725                 730                 735     


Asn Tyr Ile Val Arg Tyr Ala Asp Pro Lys Lys Ile Arg Lys Cys Thr 
            740                 745                 750         


Glu Asn Asn Glu Leu Leu Lys Phe Ala Phe Lys Asp Val Pro Asp Ser 
        755                 760                 765             


Gln Val Asp Arg Tyr Tyr Asn Ile Cys Val Thr Asn Lys Ile Thr Asn 
    770                 775                 780                 


Ala Thr Arg Glu Glu Lys Ile Glu Arg Leu Val Asp Ile Ile Lys Ser 
785                 790                 795                 800 


Met Asn Leu Ser Lys Val Ala Thr Val Lys Gln Arg Asp Lys Gln Asp 
                805                 810                 815     


Asn Val Glu Lys Gln Lys Gln Leu Ala Ile Met Ser Leu Tyr Leu Asn 
            820                 825                 830         


Ile Leu Tyr Gln Ile Ala Lys Asn Leu Val Tyr Val Asn Ser Arg Tyr 
        835                 840                 845             


Val Met Ala Phe His Ser Leu Glu Arg Asp Ser Gln Met Leu Phe Asp 
    850                 855                 860                 


Ala Tyr Tyr Asp Val Lys Arg Gly Tyr Cys Asp Leu Ser Thr Val Leu 
865                 870                 875                 880 


Leu Phe Gly Val Asp Asp Leu Gln Asn Arg Asn Arg Gly Ser Tyr Lys 
                885                 890                 895     


Tyr Leu Arg Asp Asn Arg Arg Ser Asn Lys Asp Val Ile Glu Thr Phe 
            900                 905                 910         


Gly Asp Phe Lys Gly Lys Val Ser Lys Val Val Glu Lys Lys Asn Gln 
        915                 920                 925             


Gly Leu Thr Asn Glu Ile Tyr Asp Ser Leu Cys Asn Val Ala Gly Thr 
    930                 935                 940                 


Thr Lys Thr Glu Val Gln Asn Glu Ile Lys Ser Ile Leu Lys Ser Asn 
945                 950                 955                 960 


Gly Leu Asp Glu Ser Ala Ser Ser Tyr Leu Ser His Lys Leu Val Asn 
                965                 970                 975     


Lys Val His Ser Tyr Lys Tyr Leu Lys Gln Asn Leu Asp Cys Ala Asp 
            980                 985                 990         


Asn Thr Met Ile Asn Gln Phe Arg  Asn Asn Val Ala His  Leu Asn Thr 
        995                 1000                 1005             


Ile Arg  Asn Met Asp Gly Ile  Glu Asn Val Thr Gly  Ile Thr Ser 
    1010                 1015                 1020             


Tyr Phe  Gln Ile Tyr His Tyr  Leu Met Gln Lys Ala  Leu Tyr Lys 
    1025                 1030                 1035             


Glu Phe  Lys Lys Cys Arg Glu  Asn Ala Val Arg Lys  Trp Ile Pro 
    1040                 1045                 1050             


Tyr Ile  Thr Glu Asn Ala Glu  Pro Lys Tyr Val Tyr  Trp Asn Lys 
    1055                 1060                 1065             


Lys Glu  Gln Gln Glu Val Glu  Val Ser Phe Asn Pro  Lys Ile Phe 
    1070                 1075                 1080             


Gly Tyr  Met Glu Asn Ile Lys  Asn His Ser Asn Thr  Tyr Cys Lys 
    1085                 1090                 1095             


Asp Phe  Val Lys Ala Leu Cys  Ala Pro Phe Ala Tyr  Asn Leu Pro 
    1100                 1105                 1110             


Arg Phe  Lys Asn Leu Ser Ile  Glu Glu Leu Phe Asp  Met His Glu 
    1115                 1120                 1125             


Leu Ser  Glu Glu Pro Lys Glu  Ser Met Lys Leu Thr  Asp 
    1130                 1135                 1140     


<210>  2803
<211>  1023
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2803

Met Gly Glu Glu Lys Lys Asp Ser Tyr Gly Thr Lys Lys Lys Ser Trp 
1               5                   10                  15      


Pro Lys Cys Tyr Gly Leu Lys Ser Val Leu Asp Tyr Gln Gly His Ile 
            20                  25                  30          


Val Val Thr Ser Val Ala Lys Glu Ala Asp Thr Ala Lys Asn Glu Thr 
        35                  40                  45              


Gly Gly Phe Asp Gln Glu Thr Gln Pro Asp Cys Thr Leu Ile Arg Gly 
    50                  55                  60                  


Val Asp Asp Met Glu Phe Ser Leu Ala Asp Gly Glu Lys Lys Ile Lys 
65                  70                  75                  80  


Val Lys Ala Lys Asp Ala Lys Gln Asp Phe Leu Val Glu Lys Pro Phe 
                85                  90                  95      


Ser Tyr Ala Lys Thr Glu Asp Gly Ala Pro Lys Leu Ser Pro Lys Glu 
            100                 105                 110         


Asp Tyr Leu Gly Ile Ala Lys Tyr Ile Cys His Asp Ile Phe Gly Gln 
        115                 120                 125             


Pro Leu Glu Glu Arg Tyr Asp Asp Asn Ile His Tyr Gln Ile Ala Tyr 
    130                 135                 140                 


Asn Ile Ala Asp Leu Glu Lys Ile Ile Phe Tyr Glu Val Asn Asp Ala 
145                 150                 155                 160 


Cys Phe Ala Val Asp Asn Ile Leu Lys Ala Lys Asp Phe Asp Glu Ala 
                165                 170                 175     


Ala Ser Leu Arg Pro Ile Asp Arg Ser Thr Leu Ser Lys Glu Glu Val 
            180                 185                 190         


Lys Arg Ala Glu Met Glu Arg Asp Phe Ile Gly Glu Phe Asn Pro Lys 
        195                 200                 205             


Pro Thr Phe Asn Glu Glu Val Ala Phe Ala Ala Ser Lys Pro Thr Asp 
    210                 215                 220                 


Glu Asp Gly Lys Ala Lys Val Met Ala Ala Asn Val Gln Leu Asp Thr 
225                 230                 235                 240 


Phe Ala Arg Phe Asn Arg Leu Ala Glu Pro Tyr Ser Pro Phe Phe Asn 
                245                 250                 255     


Ser Leu Phe Ile Tyr Arg Asp Lys Lys Ile Glu Ser Arg Lys Gln Pro 
            260                 265                 270         


Gly Asp Asp Tyr Phe Ala Glu His Asn Tyr Asn Val Ile Arg Val Leu 
        275                 280                 285             


Ala Ser Leu Arg His Phe Phe Thr His Arg Thr Trp Gly Lys Ala Asp 
    290                 295                 300                 


Val Ala Asp Gly Glu Ala Ser Asp Thr Ser Phe Phe Asp Phe Ser His 
305                 310                 315                 320 


Glu Leu Val Asn Lys Tyr Lys Gly Val Ala Asp Phe Ala Ser Met Thr 
                325                 330                 335     


Phe Ala Asn Lys Ala Asn Glu Leu Asn Glu Ser Phe Ala Asn Thr Cys 
            340                 345                 350         


Ala Thr Asp Leu Val Ile Leu Cys Ala Tyr Phe Gly Thr Asp Thr Lys 
        355                 360                 365             


Asp Glu Ala Gly Val Arg Lys His Leu Arg Ser Tyr Tyr Asp Phe Val 
    370                 375                 380                 


Val Gly Glu Ser Ala Lys Asn Ile Gly Ile Asn Met Thr Lys Val Arg 
385                 390                 395                 400 


Glu Lys Met Ile Asp Ala His Tyr Gly Glu Gly Ser Asp Asn Asn Leu 
                405                 410                 415     


Arg Ser Lys Glu His Asp Ser Tyr Arg Gly Arg Leu Tyr Arg Leu Phe 
            420                 425                 430         


Ser Tyr Val Leu Phe Leu Asp Val Glu Ser Asp Pro Thr Lys Phe Val 
        435                 440                 445             


Asp Pro Asn Val Ala Lys Leu Arg Leu Ala Arg Thr Asp Glu Asp Lys 
    450                 455                 460                 


Gly Ala Ile Tyr Ala Gln Met Ala Glu Asp Cys Phe Gln Ala Phe Lys 
465                 470                 475                 480 


Asp Asp Phe Ser Glu Met Ile Arg Leu Val Arg Glu Asn Val Arg Ile 
                485                 490                 495     


Asn Gly Glu Lys Ser Lys Gln Lys Phe Pro Phe Ala Ile Thr Val Glu 
            500                 505                 510         


Asn Pro Leu Leu Gly Asp Glu Glu Thr Leu Ile Phe Val Gln Met Val 
        515                 520                 525             


Phe Phe Leu Ser Leu Phe Leu Gly Glu Lys Glu Ser Asn Asp Leu Leu 
    530                 535                 540                 


Thr Ser Leu Ser Asn Lys Phe Asp Asn Ile Val Gln Phe Met Lys Val 
545                 550                 555                 560 


Leu Val Phe Leu Asp Pro Glu His Lys Gln Val His Ile Asn Gly Lys 
                565                 570                 575     


Tyr Ser Leu Phe Arg Val Glu Asn Ala Glu Lys Ile Ala Thr Gln Leu 
            580                 585                 590         


Arg Val Ala Gln Lys Val Ser Arg Met Arg Lys Asn Leu Lys Lys Ala 
        595                 600                 605             


Asp Val Ser Ala Ser Leu Leu Gly Glu Ala Met Asn Val Phe Ser Arg 
    610                 615                 620                 


His Asp Phe Tyr Ala Pro Asp Asp Val Gly Ala Asp Gly Lys Val Val 
625                 630                 635                 640 


Arg Asp Pro Arg Leu Ala Lys Met Leu Asp Asp Thr Phe Asn Ser Lys 
                645                 650                 655     


Lys Gly Ser Asp Asp Arg Thr Phe Arg Asn Phe Leu Leu Asn Asn Val 
            660                 665                 670         


Leu Ala Ser Arg Arg Phe Ala Tyr Ile Ile Arg Tyr Phe Asp Ala Arg 
        675                 680                 685             


Gly Val Arg Arg Leu Met Asp Ala Asp Ser Ala Val Arg Phe Val Leu 
    690                 695                 700                 


Gly Thr Ile Pro Glu Thr Gln Ile Arg Arg Tyr Tyr Gly Val Met Ala 
705                 710                 715                 720 


Gln Asn Pro Ala Pro Leu Pro Gln Met Ile Asp Phe Leu Ala Ser Gln 
                725                 730                 735     


Met Lys Leu Leu Asp Ile Asp Phe Leu Leu Gly Lys Lys Gly Ala Met 
            740                 745                 750         


Gln Gln Trp Ala Lys Ser Val Gly Arg Val Pro Ala Asp Lys Gln Val 
        755                 760                 765             


Phe Leu Thr Gln Val Gly Leu Tyr Leu Thr Val Ala Tyr Leu Ile Val 
    770                 775                 780                 


Lys Asn Val Val Asn Ala Asn Ala Arg Phe Ser Ser Ala Phe Ala Ser 
785                 790                 795                 800 


Tyr Glu Cys Asp Arg Ser Leu Tyr Ala Lys Ser Met Gly Glu Lys Ala 
                805                 810                 815     


Val Ser Lys Ala Gly Gly Asp Leu Asn Ser Tyr Asp Ala Asp Leu Thr 
            820                 825                 830         


Arg Phe Phe Ile Gly Gln Leu Pro Gly Lys Asp Ala Asp Gly Asn Asp 
        835                 840                 845             


Ala Leu Val Gly Leu Asn Lys Tyr Tyr Phe Lys Ser Gln Arg Tyr Leu 
    850                 855                 860                 


Leu Asp Tyr Cys Arg Tyr Phe Glu Arg Leu Glu Lys Glu Cys Asn Ile 
865                 870                 875                 880 


Asp Lys Leu Ser Val Gly Lys Leu Tyr Arg Asn His Val Val His Leu 
                885                 890                 895     


Asn Tyr Ile Ala Gly Leu Ala Asn Ile Lys Glu Ile Glu His Val Arg 
            900                 905                 910         


Ser Tyr Tyr Asp Ile Tyr Val Tyr Leu Val Glu Lys Gly Met Val Thr 
        915                 920                 925             


Ser Phe Glu Asp Pro Ala Thr Lys Ala Ile Val Leu Ala Ser Val Pro 
    930                 935                 940                 


Ser Asp Gly Ala Asp Lys Pro Ala Asp Lys Ser Leu Leu Ala Asp Leu 
945                 950                 955                 960 


Lys Phe Ser Leu Asp Lys Tyr His Ser Tyr Ser Trp Met Phe Phe Lys 
                965                 970                 975     


Trp Leu Asn Ala Met Phe Gly Tyr Cys Leu Pro Arg Phe Gln Asn Leu 
            980                 985                 990         


Thr Thr Ala Asn Leu Phe Asn Glu  Arg Asp Tyr Gly Arg  Ser Val Ile 
        995                 1000                 1005             


Lys Arg  Pro Glu Pro Lys Ser  Gln Phe Asp Ala Ala  Lys Ala Lys 
    1010                 1015                 1020             


<210>  2804
<211>  1023
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2804

Met Gly Glu Glu Lys Lys Asp Ser Tyr Gly Thr Lys Lys Lys Ser Trp 
1               5                   10                  15      


Pro Lys Cys Tyr Gly Leu Lys Ser Val Leu Asp Tyr Gln Gly His Ile 
            20                  25                  30          


Val Val Thr Ser Val Ala Lys Glu Ala Asp Thr Ala Lys Asn Glu Thr 
        35                  40                  45              


Gly Gly Phe Asp Gln Glu Thr Gln Pro Asp Cys Thr Leu Ile Arg Gly 
    50                  55                  60                  


Val Asp Asp Met Glu Phe Ser Leu Ala Asp Gly Glu Lys Lys Ile Lys 
65                  70                  75                  80  


Val Lys Ala Lys Asp Ala Lys Gln Asp Phe Leu Val Glu Lys Pro Phe 
                85                  90                  95      


Ser Tyr Ala Lys Thr Glu Asp Gly Ala Pro Lys Leu Ser Pro Lys Glu 
            100                 105                 110         


Asp Tyr Leu Gly Ile Ala Lys Tyr Ile Cys His Asp Ile Phe Gly Gln 
        115                 120                 125             


Pro Leu Glu Glu Arg Tyr Asp Asp Asn Ile His Tyr Gln Ile Ala Tyr 
    130                 135                 140                 


Asn Ile Ala Asp Leu Glu Lys Ile Ile Phe Tyr Glu Val Asn Asp Ala 
145                 150                 155                 160 


Cys Phe Ala Val Asp Asn Ile Leu Lys Ala Lys Asp Phe Asp Glu Ala 
                165                 170                 175     


Ala Ser Leu Arg Pro Ile Asp Arg Ser Thr Leu Ser Lys Glu Glu Val 
            180                 185                 190         


Lys Arg Ala Glu Met Glu Arg Asp Phe Ile Gly Glu Phe Asn Pro Lys 
        195                 200                 205             


Pro Thr Phe Asn Glu Glu Val Ala Phe Ala Ala Ser Lys Pro Thr Asp 
    210                 215                 220                 


Glu Asp Gly Lys Ala Lys Val Met Ala Ala Asn Val Gln Leu Asp Thr 
225                 230                 235                 240 


Phe Ala Arg Phe Asn Arg Leu Ala Glu Pro Tyr Ser Pro Phe Phe Asn 
                245                 250                 255     


Ser Leu Phe Ile Tyr Arg Asp Lys Lys Ile Glu Ser Arg Lys Gln Pro 
            260                 265                 270         


Gly Asp Asp Tyr Phe Ala Glu His Asn Tyr Asn Val Ile Arg Val Leu 
        275                 280                 285             


Ala Ser Leu Arg His Phe Phe Thr His Arg Thr Trp Gly Lys Ala Asp 
    290                 295                 300                 


Val Ala Asp Gly Glu Ala Ser Asp Thr Ser Phe Phe Asp Phe Ser His 
305                 310                 315                 320 


Glu Leu Val Asn Lys Tyr Lys Gly Val Ala Asp Phe Ala Ser Met Thr 
                325                 330                 335     


Phe Ala Asn Lys Ala Asn Glu Leu Asn Glu Ser Phe Ala Asn Thr Cys 
            340                 345                 350         


Ala Thr Asp Leu Val Ile Leu Cys Ala Tyr Phe Gly Thr Asp Thr Lys 
        355                 360                 365             


Asp Glu Ala Gly Val Arg Lys His Leu Arg Ser Tyr Tyr Asp Phe Val 
    370                 375                 380                 


Val Gly Glu Ser Ala Lys Asn Ile Gly Ile Asn Met Thr Lys Val Arg 
385                 390                 395                 400 


Glu Lys Met Ile Asp Ala His Tyr Gly Glu Gly Ser Asp Asn Asn Leu 
                405                 410                 415     


Arg Ser Lys Glu His Asp Ser Tyr Arg Gly Arg Leu Tyr Arg Leu Phe 
            420                 425                 430         


Ser Tyr Val Leu Phe Leu Asp Val Glu Ser Asp Pro Thr Lys Phe Val 
        435                 440                 445             


Asp Pro Asn Val Ala Lys Leu Arg Leu Ala Arg Thr Asp Glu Asp Lys 
    450                 455                 460                 


Gly Ala Ile Tyr Ala Gln Met Ala Glu Asp Cys Phe Gln Ala Phe Lys 
465                 470                 475                 480 


Asp Asp Phe Ser Glu Met Ile Arg Leu Val Arg Glu Asn Val Arg Ile 
                485                 490                 495     


Asn Gly Glu Lys Ser Lys Gln Lys Phe Pro Phe Ala Ile Thr Val Glu 
            500                 505                 510         


Asn Pro Leu Leu Gly Asp Glu Glu Thr Leu Ile Phe Val Gln Met Val 
        515                 520                 525             


Phe Phe Leu Ser Leu Phe Leu Gly Glu Lys Glu Ser Asn Asp Leu Leu 
    530                 535                 540                 


Thr Ser Leu Ser Asn Lys Phe Asp Asn Ile Val Gln Phe Met Lys Val 
545                 550                 555                 560 


Leu Val Phe Leu Asp Pro Glu His Lys Gln Val His Ile Asn Gly Lys 
                565                 570                 575     


Tyr Ser Leu Phe Arg Val Glu Asn Ala Glu Lys Ile Ala Thr Gln Leu 
            580                 585                 590         


Arg Val Ala Gln Lys Val Ser Arg Met Arg Lys Asn Leu Lys Lys Ala 
        595                 600                 605             


Asp Val Ser Ala Ser Leu Leu Gly Glu Ala Met Asn Val Phe Ser Arg 
    610                 615                 620                 


His Asp Phe Tyr Ala Pro Asp Asp Val Gly Ala Asp Gly Lys Val Val 
625                 630                 635                 640 


Arg Asp Pro Arg Leu Ala Lys Met Leu Asp Asp Thr Phe Asn Ser Lys 
                645                 650                 655     


Lys Gly Ser Asp Asp Arg Thr Phe Arg Asn Phe Leu Leu Asn Asn Val 
            660                 665                 670         


Leu Ala Ser Arg Arg Phe Ala Tyr Ile Ile Arg Tyr Phe Asp Ala Arg 
        675                 680                 685             


Gly Val Arg Arg Leu Met Asp Ala Asp Ser Ala Val Arg Phe Val Leu 
    690                 695                 700                 


Gly Thr Ile Pro Glu Thr Gln Ile Arg Arg Tyr Tyr Gly Val Met Ala 
705                 710                 715                 720 


Gln Asn Pro Ala Pro Leu Pro Gln Met Ile Asp Phe Leu Ala Ser Gln 
                725                 730                 735     


Met Lys Leu Leu Asp Ile Asp Phe Leu Leu Gly Lys Lys Gly Ala Met 
            740                 745                 750         


Gln Gln Trp Ala Lys Ser Val Gly Arg Val Pro Ala Asp Lys Gln Val 
        755                 760                 765             


Phe Leu Thr Gln Val Gly Leu Tyr Leu Thr Val Ala Tyr Leu Ile Val 
    770                 775                 780                 


Lys Asn Val Val Asn Ala Asn Ala Arg Phe Ser Ser Ala Phe Ala Ser 
785                 790                 795                 800 


Tyr Glu Cys Asp Arg Ser Leu Tyr Ala Lys Ser Met Gly Glu Lys Ala 
                805                 810                 815     


Val Ser Lys Ala Gly Gly Asp Leu Asn Ser Tyr Asp Ala Asp Leu Thr 
            820                 825                 830         


Arg Phe Phe Ile Gly Gln Leu Pro Gly Lys Asp Ala Asp Gly Asn Asp 
        835                 840                 845             


Ala Leu Val Gly Leu Asn Lys Tyr Tyr Phe Lys Ser Gln Arg Tyr Leu 
    850                 855                 860                 


Leu Asp Tyr Cys Arg Tyr Phe Glu Arg Leu Glu Lys Glu Cys Asn Ile 
865                 870                 875                 880 


Asp Lys Leu Ser Val Gly Lys Leu Tyr Arg Asn His Val Val His Leu 
                885                 890                 895     


Asn Tyr Ile Ala Gly Leu Ala Asn Ile Lys Glu Ile Glu His Val Arg 
            900                 905                 910         


Ser Tyr Tyr Asp Ile Tyr Val Tyr Leu Val Glu Lys Gly Met Val Thr 
        915                 920                 925             


Ser Phe Glu Asp Pro Ala Thr Lys Ala Ile Val Leu Ala Ser Val Pro 
    930                 935                 940                 


Ser Asp Gly Ala Asp Lys Pro Ala Asp Lys Ser Leu Leu Ala Asp Leu 
945                 950                 955                 960 


Lys Phe Ser Leu Asp Lys Tyr His Ser Tyr Ser Trp Met Phe Phe Lys 
                965                 970                 975     


Trp Leu Asn Ala Met Phe Gly Tyr Cys Leu Pro Arg Phe Gln Asn Leu 
            980                 985                 990         


Thr Thr Ala Asn Leu Phe Asn Glu  Arg Asp Tyr Gly Arg  Ser Val Ile 
        995                 1000                 1005             


Lys Arg  Pro Glu Pro Lys Ser  Gln Phe Asp Ala Ala  Lys Ala Lys 
    1010                 1015                 1020             


<210>  2805
<211>  1023
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2805

Met Gly Glu Glu Lys Lys Asp Ser Tyr Gly Thr Lys Lys Lys Ser Trp 
1               5                   10                  15      


Pro Lys Cys Tyr Gly Leu Lys Ser Val Leu Asp Tyr Gln Gly His Ile 
            20                  25                  30          


Val Val Thr Ser Val Ala Lys Glu Ala Asp Thr Ala Lys Asn Glu Thr 
        35                  40                  45              


Gly Gly Phe Asp Gln Glu Thr Gln Pro Asp Cys Thr Leu Ile Arg Gly 
    50                  55                  60                  


Val Asp Asp Met Glu Phe Ser Leu Ala Asp Gly Glu Lys Lys Ile Lys 
65                  70                  75                  80  


Val Lys Ala Lys Asp Ala Lys Gln Asp Phe Leu Val Glu Lys Pro Phe 
                85                  90                  95      


Ser Tyr Ala Lys Thr Glu Asp Gly Ala Pro Lys Leu Ser Pro Lys Glu 
            100                 105                 110         


Asp Tyr Leu Gly Ile Ala Lys Tyr Ile Cys His Asp Ile Phe Gly Gln 
        115                 120                 125             


Pro Leu Glu Glu Arg Tyr Asp Asp Asn Ile His Tyr Gln Ile Ala Tyr 
    130                 135                 140                 


Asn Ile Ala Asp Leu Glu Lys Ile Ile Phe Tyr Glu Val Asn Asp Ala 
145                 150                 155                 160 


Cys Phe Ala Val Asp Asn Ile Leu Lys Ala Lys Asp Phe Asp Glu Ala 
                165                 170                 175     


Ala Ser Leu Arg Pro Ile Asp Arg Ser Thr Leu Ser Lys Glu Glu Val 
            180                 185                 190         


Lys Arg Ala Glu Met Glu Arg Asp Phe Ile Gly Glu Phe Asn Pro Lys 
        195                 200                 205             


Pro Thr Phe Asn Glu Glu Val Ala Phe Ala Ala Ser Lys Pro Thr Asp 
    210                 215                 220                 


Glu Asp Gly Lys Ala Lys Val Met Ala Ala Asn Val Gln Leu Asp Thr 
225                 230                 235                 240 


Phe Ala Arg Phe Asn Arg Leu Ala Glu Pro Tyr Ser Pro Phe Phe Asn 
                245                 250                 255     


Ser Leu Phe Ile Tyr Arg Asp Lys Lys Ile Glu Ser Arg Lys Gln Pro 
            260                 265                 270         


Gly Asp Asp Tyr Phe Ala Glu His Asn Tyr Asn Val Ile Arg Val Leu 
        275                 280                 285             


Ala Ser Leu Arg His Phe Phe Thr His Arg Thr Trp Gly Lys Ala Asp 
    290                 295                 300                 


Val Ala Asp Gly Glu Ala Ser Asp Thr Ser Phe Phe Asp Phe Ser His 
305                 310                 315                 320 


Glu Leu Val Asn Lys Tyr Lys Gly Val Ala Asp Phe Ala Ser Met Thr 
                325                 330                 335     


Phe Ala Asn Lys Ala Asn Glu Leu Asn Glu Ser Phe Ala Asn Thr Cys 
            340                 345                 350         


Ala Thr Asp Leu Val Ile Leu Cys Ala Tyr Phe Gly Thr Asp Thr Lys 
        355                 360                 365             


Asp Glu Ala Gly Val Arg Lys His Leu Arg Ser Tyr Tyr Asp Phe Val 
    370                 375                 380                 


Val Gly Glu Ser Ala Lys Asn Ile Gly Ile Asn Met Thr Lys Val Arg 
385                 390                 395                 400 


Glu Lys Met Ile Asp Ala His Tyr Gly Glu Gly Ser Asp Asn Asn Leu 
                405                 410                 415     


Arg Ser Lys Glu His Asp Ser Tyr Arg Gly Arg Leu Tyr Arg Leu Phe 
            420                 425                 430         


Ser Tyr Val Leu Phe Leu Asp Val Glu Ser Asp Pro Thr Lys Phe Val 
        435                 440                 445             


Asp Pro Asn Val Ala Lys Leu Arg Leu Ala Arg Thr Asp Glu Asp Lys 
    450                 455                 460                 


Gly Ala Ile Tyr Ala Gln Met Ala Glu Asp Cys Phe Gln Ala Phe Lys 
465                 470                 475                 480 


Asp Asp Phe Ser Glu Met Ile Arg Leu Val Arg Glu Asn Val Arg Ile 
                485                 490                 495     


Asn Gly Glu Lys Ser Lys Gln Lys Phe Pro Phe Ala Ile Thr Val Glu 
            500                 505                 510         


Asn Pro Leu Leu Gly Asp Glu Glu Thr Leu Ile Phe Val Gln Met Val 
        515                 520                 525             


Phe Phe Leu Ser Leu Phe Leu Gly Glu Lys Glu Ser Asn Asp Leu Leu 
    530                 535                 540                 


Thr Ser Leu Ser Asn Lys Phe Asp Asn Ile Val Gln Phe Met Lys Val 
545                 550                 555                 560 


Leu Val Phe Leu Asp Pro Glu His Lys Gln Val His Ile Asn Gly Lys 
                565                 570                 575     


Tyr Ser Leu Phe Arg Val Glu Asn Ala Glu Lys Ile Ala Thr Gln Leu 
            580                 585                 590         


Arg Val Ala Gln Lys Val Ser Arg Met Arg Lys Asn Leu Lys Lys Ala 
        595                 600                 605             


Asp Val Ser Ala Ser Leu Leu Gly Glu Ala Met Asn Val Phe Ser Arg 
    610                 615                 620                 


His Asp Phe Tyr Ala Pro Asp Asp Val Gly Ala Asp Gly Lys Val Val 
625                 630                 635                 640 


Arg Asp Pro Arg Leu Ala Lys Met Leu Asp Asp Thr Phe Asn Ser Lys 
                645                 650                 655     


Lys Gly Ser Asp Asp Arg Thr Phe Arg Asn Phe Leu Leu Asn Asn Val 
            660                 665                 670         


Leu Ala Ser Arg Arg Phe Ala Tyr Ile Ile Arg Tyr Phe Asp Ala Arg 
        675                 680                 685             


Gly Val Arg Arg Leu Met Asp Ala Asp Ser Ala Val Arg Phe Val Leu 
    690                 695                 700                 


Gly Thr Ile Pro Glu Thr Gln Ile Arg Arg Tyr Tyr Gly Val Met Ala 
705                 710                 715                 720 


Gln Asn Pro Ala Pro Leu Pro Gln Met Ile Asp Phe Leu Ala Ser Gln 
                725                 730                 735     


Met Lys Leu Leu Asp Ile Asp Phe Leu Leu Gly Lys Lys Gly Ala Met 
            740                 745                 750         


Gln Gln Trp Ala Lys Ser Val Gly Arg Val Pro Ala Asp Lys Gln Val 
        755                 760                 765             


Phe Leu Thr Gln Val Gly Leu Tyr Leu Thr Val Ala Tyr Leu Ile Val 
    770                 775                 780                 


Lys Asn Val Val Asn Ala Asn Ala Arg Phe Ser Ser Ala Phe Ala Ser 
785                 790                 795                 800 


Tyr Glu Cys Asp Arg Ser Leu Tyr Ala Lys Ser Met Gly Glu Lys Ala 
                805                 810                 815     


Val Ser Lys Ala Gly Gly Asp Leu Asn Ser Tyr Asp Ala Asp Leu Thr 
            820                 825                 830         


Arg Phe Phe Ile Gly Gln Leu Pro Gly Lys Asp Ala Asp Gly Asn Asp 
        835                 840                 845             


Ala Leu Val Gly Leu Asn Lys Tyr Tyr Phe Lys Ser Gln Arg Tyr Leu 
    850                 855                 860                 


Leu Asp Tyr Cys Arg Tyr Phe Glu Arg Leu Glu Lys Glu Cys Asn Ile 
865                 870                 875                 880 


Asp Lys Leu Ser Val Gly Lys Leu Tyr Arg Asn His Val Val His Leu 
                885                 890                 895     


Asn Tyr Ile Ala Gly Leu Ala Asn Ile Lys Glu Ile Glu His Val Arg 
            900                 905                 910         


Ser Tyr Tyr Asp Ile Tyr Val Tyr Leu Val Glu Lys Gly Met Val Thr 
        915                 920                 925             


Ser Phe Glu Asp Pro Ala Thr Lys Ala Ile Val Leu Ala Ser Val Pro 
    930                 935                 940                 


Ser Asp Gly Ala Asp Lys Pro Ala Asp Lys Ser Leu Leu Ala Asp Leu 
945                 950                 955                 960 


Lys Phe Ser Leu Asp Lys Tyr His Ser Tyr Ser Trp Met Phe Phe Lys 
                965                 970                 975     


Trp Leu Asn Ala Met Phe Gly Tyr Cys Leu Pro Arg Phe Gln Asn Leu 
            980                 985                 990         


Thr Thr Ala Asn Leu Phe Asn Glu  Arg Asp Tyr Gly Arg  Ser Val Ile 
        995                 1000                 1005             


Lys Arg  Pro Glu Pro Lys Ser  Gln Phe Asp Ala Ala  Lys Ala Lys 
    1010                 1015                 1020             


<210>  2806
<211>  1141
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2806

Met Gly Val Glu Lys Asn Lys Val Phe Glu Ser Val Ile Met Asn Phe 
1               5                   10                  15      


Asp Gln Glu Arg Lys Tyr Gly Phe Ile Glu Tyr Lys Glu Thr Asn Asn 
            20                  25                  30          


Leu Phe Phe His Met Glu Asn Val Lys Asn Pro Lys Glu Ile Val Lys 
        35                  40                  45              


Gly Ala Lys Val Arg Phe Glu Ile Tyr Glu Asn Pro Lys Pro Lys Lys 
    50                  55                  60                  


Gln Asn Gln Arg Phe Ser Ala Ile Asn Val Glu Val Ile Thr Asp Glu 
65                  70                  75                  80  


Thr His Lys Glu Ala Lys Ile Gln Lys Asn Glu Phe Lys Thr Phe Asp 
                85                  90                  95      


Gln Phe Thr Lys Glu Leu Gln Glu Thr Gln Lys Val Asn Gly Glu Thr 
            100                 105                 110         


Lys Lys Glu His Ile Thr Lys Asn Lys His Thr Asn Val Lys Ala Ala 
        115                 120                 125             


Gly Val Lys Ser Val Phe Ala Val Asp Asp Gly Asn Val Leu Ile Thr 
    130                 135                 140                 


Ser Phe Gly Arg Gly Asn Ala Ala Asp Ile Glu Thr Leu Lys Ser Asp 
145                 150                 155                 160 


Asp Asp Lys Thr Ile Asn Leu Thr Glu Thr Glu Asn Gln Lys Lys Tyr 
                165                 170                 175     


Val Val Thr Asn Lys Arg Ser Asn Val Lys Gly Leu Ala Asp Asn Pro 
            180                 185                 190         


Thr Lys Val Glu Ser Ile Ile Pro Gly Glu Thr Gln Ile Gly Phe Lys 
        195                 200                 205             


Ser Ile Leu Glu Lys His Phe Phe Gly Arg Thr Phe Asn Asp Asn Ile 
    210                 215                 220                 


His Ile Gln Ile Ile His Asn Ile Leu Asp Ile Lys Lys Ile Leu Ala 
225                 230                 235                 240 


Val His Thr Asn Asn Ile Val Tyr Ala Leu Asp Asn Ile His Glu Arg 
                245                 250                 255     


Gly Arg Glu Asn Ser Ala Glu Lys Pro Ile Asp Met Ile Gly Ala Gly 
            260                 265                 270         


Gly Ile Ser Thr Ser Lys Glu Tyr Glu Gln Tyr Cys Ser Glu Lys Ser 
        275                 280                 285             


Asp Tyr Glu Asp Asn Phe Leu Lys Gln Leu Ile Asn Asn Glu Arg Ile 
    290                 295                 300                 


Ala Tyr Phe Gly Asn Ala Phe Phe Lys Asp Glu Gly Asn Lys Lys Val 
305                 310                 315                 320 


Met Arg Thr Glu Lys Glu Ile Tyr Tyr Ile Leu Gly Met Leu Asn Glu 
                325                 330                 335     


Val Arg Asn Val Ser Thr His Phe Thr Glu Glu Asp Asn Arg Asp Trp 
            340                 345                 350         


Ala Lys Ala Asn Leu Tyr Asn Leu Ser Asn Arg Leu Lys Val Gly Ser 
        355                 360                 365             


Lys Glu Val Leu Asn Gln Leu Tyr Lys Glu Lys Ile Asp Lys Ile Asp 
    370                 375                 380                 


Ala Asn Gly Phe Val Asn Lys Gly Cys Lys Arg Asp Phe Ser Ile Leu 
385                 390                 395                 400 


Phe Lys Ser Leu Asn Leu Thr Thr Asp Lys Asp Lys Gly Glu Leu Val 
                405                 410                 415     


Val Gly Phe Tyr Asp Phe Ser Ile Arg Lys Asn Tyr Lys Asn Ile Gly 
            420                 425                 430         


Phe Ser Ile Lys Thr Leu Arg Glu Tyr Met Leu Lys Ile Ser Asn Ser 
        435                 440                 445             


Thr Leu Cys Ala Asp Thr Ile Ser Asn Asn Ala Ile Arg Pro Lys Ala 
    450                 455                 460                 


Tyr Lys Leu Tyr Asp Phe Ile Ile Trp His Tyr Tyr Met Asn Lys Pro 
465                 470                 475                 480 


Asp Lys Ile Asn Asp Phe Val Glu Lys Leu Arg Thr Gln Asn Lys Asn 
                485                 490                 495     


Asp Glu Lys Ile Lys Leu Tyr Tyr Asp Glu Ala Val Cys Leu Leu Ser 
            500                 505                 510         


Glu Leu Gly Arg Glu Ile His Thr Met Thr Ser Cys Val His Asn Ile 
        515                 520                 525             


Glu Asn Thr Ser Tyr Glu Ile Thr Asp Lys Lys Gln Lys Glu Tyr Tyr 
    530                 535                 540                 


Lys Met Gln Ile Asn Ser Leu Asn Ser Ala Asp Lys Val Ser Asp Phe 
545                 550                 555                 560 


Ser Lys Val Ile Tyr Leu Val Thr Leu Phe Leu Asp Gly Lys Glu Ile 
                565                 570                 575     


Asn Asp Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp Asn Ile Ala Ser 
            580                 585                 590         


Leu Leu Ser Val Leu Glu Lys Gln Ser Gly Lys Lys Val Glu Phe Val 
        595                 600                 605             


Glu Asn Tyr Ser Phe Phe Asn Ser Ser Asn Leu Leu Lys Glu Lys Thr 
    610                 615                 620                 


Leu Asn Lys Ser Glu Asn Tyr Thr Cys Lys Ile Val Glu Glu Leu Arg 
625                 630                 635                 640 


Glu Ile Asn Ser Phe Ala Arg Met Thr Gly Asp Cys Lys Ile Arg Lys 
                645                 650                 655     


Ser Ala Phe Glu Asp Ala Ser Gln Leu Leu Gly Tyr His Asp Lys Thr 
            660                 665                 670         


Val Asn Asn Leu Phe Glu Val Leu Arg Leu Lys Glu Leu Glu Ser Lys 
        675                 680                 685             


Asp Trp Lys Lys Arg Thr Asp Asp Glu Gln Gln Glu Tyr Asp Arg Leu 
    690                 695                 700                 


Leu Asn Lys His His Tyr Phe Lys Ser Gly Lys Lys Leu Pro Asp Thr 
705                 710                 715                 720 


Gly Leu Arg Asn Phe Ile Ile Asn Asn Val Ile Glu Ser Arg Arg Phe 
                725                 730                 735     


Asn Tyr Ile Val Arg Tyr Ala Asp Pro Lys Lys Ile Arg Lys Cys Thr 
            740                 745                 750         


Glu Asn Asn Glu Leu Leu Lys Phe Ala Phe Lys Asp Val Pro Asp Ser 
        755                 760                 765             


Gln Val Asp Arg Tyr Tyr Asn Ile Cys Val Thr Asn Lys Ile Thr Asn 
    770                 775                 780                 


Ala Thr Arg Glu Glu Lys Ile Glu Arg Leu Val Asp Ile Ile Lys Ser 
785                 790                 795                 800 


Met Asn Leu Ser Lys Val Ala Thr Val Lys Gln Arg Asp Lys Gln Asp 
                805                 810                 815     


Asn Val Glu Lys Gln Lys Gln Leu Ala Ile Met Ser Leu Tyr Leu Asn 
            820                 825                 830         


Ile Leu Tyr Gln Ile Ala Lys Asn Leu Val Tyr Val Asn Ser Arg Tyr 
        835                 840                 845             


Val Met Ala Phe His Ser Leu Glu Arg Asp Ser Gln Met Leu Phe Asp 
    850                 855                 860                 


Ala Tyr Tyr Asp Val Lys Arg Gly Tyr Cys Asp Leu Ser Thr Val Leu 
865                 870                 875                 880 


Leu Phe Gly Val Asp Asp Leu Gln Asn Arg Asn Arg Gly Ser Tyr Lys 
                885                 890                 895     


Tyr Leu Arg Asp Asn Arg Arg Ser Asn Lys Asp Val Ile Glu Thr Phe 
            900                 905                 910         


Gly Asp Phe Lys Gly Lys Val Ser Lys Val Val Glu Lys Lys Asn Gln 
        915                 920                 925             


Gly Leu Thr Asn Glu Ile Tyr Asp Ser Leu Cys Asn Val Ala Gly Thr 
    930                 935                 940                 


Thr Lys Thr Glu Val Gln Asn Glu Ile Lys Ser Ile Leu Lys Ser Asn 
945                 950                 955                 960 


Gly Leu Asp Glu Ser Ala Ser Ser Tyr Leu Ser His Lys Leu Val Asn 
                965                 970                 975     


Lys Val His Ser Tyr Lys Tyr Leu Lys Gln Asn Leu Asp Cys Ala Asp 
            980                 985                 990         


Asn Thr Met Ile Asn Gln Phe Arg  Asn Asn Val Ala His  Leu Asn Thr 
        995                 1000                 1005             


Ile Arg  Asn Met Asp Gly Ile  Glu Asn Val Thr Gly  Ile Thr Ser 
    1010                 1015                 1020             


Tyr Phe  Gln Ile Tyr His Tyr  Leu Met Gln Lys Ala  Leu Tyr Lys 
    1025                 1030                 1035             


Glu Phe  Lys Lys Cys Arg Glu  Asn Ala Val Arg Lys  Trp Ile Pro 
    1040                 1045                 1050             


Tyr Ile  Thr Glu Asn Ala Glu  Pro Lys Tyr Val Tyr  Trp Asn Lys 
    1055                 1060                 1065             


Lys Glu  Gln Gln Glu Val Glu  Val Ser Phe Asn Pro  Lys Ile Phe 
    1070                 1075                 1080             


Gly Tyr  Met Glu Asn Ile Lys  Asn His Ser Asn Thr  Tyr Cys Lys 
    1085                 1090                 1095             


Asp Phe  Val Lys Ala Leu Cys  Ala Pro Phe Ala Tyr  Asn Leu Pro 
    1100                 1105                 1110             


Arg Phe  Lys Asn Leu Ser Ile  Glu Glu Leu Phe Asp  Met His Glu 
    1115                 1120                 1125             


Leu Ser  Glu Glu Pro Lys Glu  Ser Met Lys Leu Thr  Asp 
    1130                 1135                 1140     


<210>  2807
<211>  960
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2807

Met Ala Lys Lys Leu Asn Ala Lys Glu Lys Arg Leu Leu Ser Gln Gln 
1               5                   10                  15      


Ala Gln Lys Asp Lys Tyr Lys Lys Met Glu Glu Glu Arg Gln Ala Ala 
            20                  25                  30          


Glu Gln Ala Arg Leu Ala Glu Glu Ala Arg Gln Lys Ala Glu Thr Glu 
        35                  40                  45              


Arg Lys Lys Lys Glu Ala Leu Glu Lys Glu Ala Arg Glu Lys Leu Glu 
    50                  55                  60                  


Lys Glu Leu Leu Glu Lys Asn Pro Ser Leu Lys Lys Val Lys Lys Ser 
65                  70                  75                  80  


Lys Ala Lys Ala Ala Gly Leu Lys Ser Thr Phe Ala Ile Gly Asn Glu 
                85                  90                  95      


Leu Leu Met Thr Ser Phe Gly Lys Gly Asn Glu Ala Val Pro Glu His 
            100                 105                 110         


Tyr Ile Phe Glu Asn Gly Met Ile Ser Met Gln Asn Pro Pro Ala Phe 
        115                 120                 125             


Asp Val Glu Asn Arg Gly Thr Ser Phe Ser Ile Ala Gly Lys Asn Ala 
    130                 135                 140                 


Met Asn Ala Ile Ala Asp Asp Pro Arg Arg Thr Ser Lys Lys Val Ile 
145                 150                 155                 160 


Gly Glu Asp Leu Ile Gly Ala Lys Ser Ala Leu Glu Lys Arg Tyr Phe 
                165                 170                 175     


Gly Lys Thr Phe Glu Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
            180                 185                 190         


Leu Asp Ile Glu Lys Ile Leu Ser Lys His Ile Asn Asn Ile Val Phe 
        195                 200                 205             


Ser Ile Asn Asn Ile Arg Gly Ile Ala Asp Pro Glu Arg Asp Asp Leu 
    210                 215                 220                 


Ile Gly Tyr Met Ser Leu Arg Asp Ser Tyr Glu Tyr Phe Met Asp Glu 
225                 230                 235                 240 


Lys Asn Glu Lys Arg Lys Val Leu Arg Glu Ser Tyr Arg Lys Leu Phe 
                245                 250                 255     


Lys Ser Ser Arg Leu Ser Tyr Phe Gly Ser Ala Phe Tyr Val Glu Lys 
            260                 265                 270         


Gln Ser Thr Gln Lys Lys Lys Ser Gly Gln Lys Asn Phe Glu Leu Arg 
        275                 280                 285             


Asn Glu Lys Asp Cys Tyr Tyr Met Leu Ala Leu Leu Gly Glu Leu Arg 
    290                 295                 300                 


Gln Val Leu Ala His Ser Ser Ala Gln Lys Gln Gly Lys Glu Gln Thr 
305                 310                 315                 320 


Glu Ala Arg Ser Ser Val Tyr Asn Leu Arg Thr Val Gly Asn Asn Asp 
                325                 330                 335     


Met Arg Lys Ile Leu Asn Ser Leu Tyr Ala Glu Arg Val Asp Ala Leu 
            340                 345                 350         


Asn Glu Asn Phe Met Asn Tyr Ala Lys Lys Asp Leu Thr Ile Leu Phe 
        355                 360                 365             


Gly Ile Met Asp Ala Ser Ser Tyr Glu Lys Lys Ala Glu Ile Ala Arg 
    370                 375                 380                 


Asp Phe Tyr Asp Phe Thr Val Arg Lys Ser Tyr Lys Asn Ile Gly Phe 
385                 390                 395                 400 


Ser Ile Lys Lys Ile Arg Glu Arg Met Met Asp Cys Phe Phe Ala Asn 
                405                 410                 415     


Val Lys Glu Ile Thr Pro Asp Ser Pro Asp Phe Gln Ser Val Arg Gln 
            420                 425                 430         


Lys Phe Tyr Lys Ile Leu Asp Phe Leu Leu Phe Thr Tyr Tyr Lys Asp 
        435                 440                 445             


Asn Lys Glu Glu Thr Lys Lys Ile Ile Ala Ala Leu Arg Ala Ser Leu 
    450                 455                 460                 


Thr Glu Leu Glu Lys Glu Leu Phe Tyr Gln Lys Gln Ala Asn Ile Leu 
465                 470                 475                 480 


Trp Asn Lys Met Gln Met Val Val Thr Glu Gln Ile Tyr Pro Arg Thr 
                485                 490                 495     


Lys Gly Ser Ala Ile Gln Asn Leu Ile Ala Asp Pro Glu Ile Ser Ala 
            500                 505                 510         


Asp Met Leu Lys Gly Val Met Ile Thr Pro Glu Ser Val Asp Tyr Phe 
        515                 520                 525             


Ser Lys Met Ile Tyr Leu Leu Thr Leu Phe Ile Asp Gly Lys Glu Ile 
    530                 535                 540                 


Asn Asp Leu Leu Thr Thr Met Ile Asn Lys Phe Glu Asn Ile Ala Ser 
545                 550                 555                 560 


Phe Val Ser Val Leu Lys Asp Arg Gly Leu Pro Cys Asn Phe Arg Asn 
                565                 570                 575     


Asp Tyr Ser Val Phe Asn Asn Ala Leu Lys Ile Ser Ala Glu Leu Arg 
            580                 585                 590         


Glu Ile Asn Ser Phe Ala Arg Met Glu Lys Ala Thr Pro Gly Ala Lys 
        595                 600                 605             


Lys Gln Met Phe Leu Asp Ala Ala Ile Ile Leu Gly Ser Asn Glu Ser 
    610                 615                 620                 


Ala Glu Glu Leu Ser Glu Tyr Phe Asp Glu Met Leu Asp Lys Gln Lys 
625                 630                 635                 640 


Gly Lys Arg Thr Pro Gly Gly Lys Lys Asp Met Gly Phe Arg Asn Phe 
                645                 650                 655     


Leu Ile Lys Asn Val Ile Glu Ser Asp Arg Phe His Tyr Leu Ile Arg 
            660                 665                 670         


Tyr Gly His Pro Leu His Ile Arg Lys Leu Ala Glu Asn Lys Asn Val 
        675                 680                 685             


Ile Ala Phe Val Leu Lys Gln Ile Pro Glu Pro Gln Ile Asp Arg Tyr 
    690                 695                 700                 


Cys Lys Ile Cys Ala Leu Pro Ala Glu Ser Asn Phe Ala Gln Lys Ile 
705                 710                 715                 720 


Leu Arg Leu Thr Asp Leu Ile Ala Glu Met Asn Phe Arg Gln Phe Glu 
                725                 730                 735     


Asn Val Arg Gln Thr Glu Lys Asn Glu Gln Lys Gln Ile Leu Gln Gly 
            740                 745                 750         


Ile Leu Ser Leu Tyr Leu Thr Val Leu Tyr Leu Leu Thr Lys Asn Leu 
        755                 760                 765             


Val Tyr Val Asn Ser Arg Tyr Phe Leu Ala Phe His Cys Leu Glu Arg 
    770                 775                 780                 


Asp Thr Glu Leu Leu Gly Ser Gln Ala Gly His Lys Asn Ala Glu Lys 
785                 790                 795                 800 


Gln Leu Ile Ala Ser Tyr Ser Ala Leu Thr Gln Gln Phe Leu Asp Glu 
                805                 810                 815     


Gly Lys Leu Asn Arg His Ala Arg Glu Tyr Leu Thr Val Asn Ile Gln 
            820                 825                 830         


Asn Ser Asp Asp Trp Thr Ile Ala Gln Tyr Arg Asn Asn Ala Ala His 
        835                 840                 845             


Leu Asn Ala Ile Arg Asn Ala His Leu Tyr Ile Arg Glu Met Lys Ser 
    850                 855                 860                 


Val Arg Ser Tyr Phe Glu Leu Tyr His Tyr Leu Thr Gln Arg Ala Leu 
865                 870                 875                 880 


Leu Asp Lys Tyr Glu Asn Val Pro Tyr His Pro Gln Val Asn Glu Lys 
                885                 890                 895     


Thr Leu Lys Tyr Phe Glu Leu Leu Lys Glu Asn Gly Trp Tyr Cys Lys 
            900                 905                 910         


Asp Phe Val Lys Ala Leu Asn Val Pro Phe Gly Tyr Asn Leu Pro Arg 
        915                 920                 925             


Tyr Lys Asn Leu Ser Ile Asp Ala Leu Phe Asp Lys Asp Arg Pro Gln 
    930                 935                 940                 


Glu Glu Asp Glu Asn His Leu Tyr Thr Cys Gln Asn Ile Lys Lys Ser 
945                 950                 955                 960 


<210>  2808
<211>  1141
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2808

Met Gly Val Glu Lys Asn Lys Val Phe Glu Ser Val Ile Met Asn Phe 
1               5                   10                  15      


Asp Gln Glu Arg Lys Tyr Gly Phe Ile Glu Tyr Lys Glu Thr Asn Asn 
            20                  25                  30          


Leu Phe Phe His Met Glu Asn Val Lys Asn Pro Lys Glu Ile Val Lys 
        35                  40                  45              


Gly Ala Lys Val Arg Phe Glu Ile Tyr Glu Asn Pro Lys Pro Lys Lys 
    50                  55                  60                  


Gln Asn Gln Arg Phe Ser Ala Ile Asn Val Glu Val Ile Thr Asp Glu 
65                  70                  75                  80  


Thr His Lys Glu Ala Lys Ile Gln Lys Asn Glu Phe Lys Thr Phe Asp 
                85                  90                  95      


Gln Phe Thr Lys Glu Leu Gln Glu Thr Gln Lys Val Asn Gly Glu Thr 
            100                 105                 110         


Lys Lys Glu His Ile Thr Lys Asn Lys His Thr Asn Val Lys Ala Ala 
        115                 120                 125             


Gly Val Lys Ser Val Phe Ala Val Asp Asp Gly Asn Val Leu Ile Thr 
    130                 135                 140                 


Ser Phe Gly Arg Gly Asn Ala Ala Asp Ile Glu Thr Leu Lys Ser Asp 
145                 150                 155                 160 


Asp Asp Lys Thr Ile Asn Leu Thr Glu Thr Glu Asn Gln Lys Lys Tyr 
                165                 170                 175     


Val Val Thr Asn Lys Arg Ser Asn Val Lys Gly Leu Ala Asp Asn Pro 
            180                 185                 190         


Thr Lys Val Glu Ser Ile Ile Pro Gly Glu Thr Gln Ile Gly Phe Lys 
        195                 200                 205             


Ser Ile Leu Glu Lys His Phe Phe Gly Arg Thr Phe Asn Asp Asn Ile 
    210                 215                 220                 


His Ile Gln Ile Ile His Asn Ile Leu Asp Ile Lys Lys Ile Leu Ala 
225                 230                 235                 240 


Val His Thr Asn Asn Ile Val Tyr Ala Leu Asp Asn Ile His Glu Arg 
                245                 250                 255     


Gly Arg Glu Asn Ser Ala Glu Lys Pro Ile Asp Met Ile Gly Ala Gly 
            260                 265                 270         


Gly Ile Ser Thr Ser Lys Glu Tyr Glu Gln Tyr Cys Ser Glu Lys Ser 
        275                 280                 285             


Asp Tyr Glu Asp Asn Phe Leu Lys Gln Leu Ile Asn Asn Glu Arg Ile 
    290                 295                 300                 


Ala Tyr Phe Gly Asn Ala Phe Phe Lys Asp Glu Gly Asn Lys Lys Val 
305                 310                 315                 320 


Met Arg Thr Glu Lys Glu Ile Tyr Tyr Ile Leu Gly Met Leu Asn Glu 
                325                 330                 335     


Val Arg Asn Val Ser Thr His Phe Thr Glu Glu Asp Asn Arg Asp Trp 
            340                 345                 350         


Ala Lys Ala Asn Leu Tyr Asn Leu Ser Asn Arg Leu Lys Val Gly Ser 
        355                 360                 365             


Lys Glu Val Leu Asn Gln Leu Tyr Lys Glu Lys Ile Asp Lys Ile Asp 
    370                 375                 380                 


Ala Asn Gly Phe Val Asn Lys Gly Cys Lys Arg Asp Phe Ser Ile Leu 
385                 390                 395                 400 


Phe Lys Ser Leu Asn Leu Thr Thr Asp Lys Asp Lys Gly Glu Leu Val 
                405                 410                 415     


Val Gly Phe Tyr Asp Phe Ser Ile Arg Lys Asn Tyr Lys Asn Ile Gly 
            420                 425                 430         


Phe Ser Ile Lys Thr Leu Arg Glu Tyr Met Leu Lys Ile Ser Asn Ser 
        435                 440                 445             


Thr Leu Cys Ala Asp Thr Ile Ser Asn Asn Ala Ile Arg Pro Lys Ala 
    450                 455                 460                 


Tyr Lys Leu Tyr Asp Phe Ile Ile Trp His Tyr Tyr Met Asn Lys Pro 
465                 470                 475                 480 


Asp Lys Ile Asn Asp Phe Val Glu Lys Leu Arg Thr Gln Asn Lys Asn 
                485                 490                 495     


Asp Glu Lys Ile Lys Leu Tyr Tyr Asp Glu Ala Val Cys Leu Leu Ser 
            500                 505                 510         


Glu Leu Gly Arg Glu Ile His Thr Met Thr Ser Cys Val His Asn Ile 
        515                 520                 525             


Glu Asn Thr Ser Tyr Glu Ile Thr Asp Lys Lys Gln Lys Glu Tyr Tyr 
    530                 535                 540                 


Lys Met Gln Ile Asn Ser Leu Asn Ser Ala Asp Lys Val Ser Asp Phe 
545                 550                 555                 560 


Ser Lys Val Ile Tyr Leu Val Thr Leu Phe Leu Asp Gly Lys Glu Ile 
                565                 570                 575     


Asn Asp Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp Asn Ile Ala Ser 
            580                 585                 590         


Leu Leu Ser Val Leu Glu Lys Gln Ser Gly Lys Lys Val Glu Phe Val 
        595                 600                 605             


Glu Asn Tyr Ser Phe Phe Asn Ser Ser Asn Leu Leu Lys Glu Lys Thr 
    610                 615                 620                 


Leu Asn Lys Ser Glu Asn Tyr Thr Cys Lys Ile Val Glu Glu Leu Arg 
625                 630                 635                 640 


Glu Ile Asn Ser Phe Ala Arg Met Thr Gly Asp Cys Lys Ile Arg Lys 
                645                 650                 655     


Ser Ala Phe Glu Asp Ala Ser Gln Leu Leu Gly Tyr His Asp Lys Thr 
            660                 665                 670         


Val Asn Asn Leu Phe Glu Val Leu Arg Leu Lys Glu Leu Glu Ser Lys 
        675                 680                 685             


Asp Trp Lys Lys Arg Thr Asp Asp Glu Gln Gln Glu Tyr Asp Arg Leu 
    690                 695                 700                 


Leu Asn Lys His His Tyr Phe Lys Ser Gly Lys Lys Leu Pro Asp Thr 
705                 710                 715                 720 


Gly Leu Arg Asn Phe Ile Ile Asn Asn Val Ile Glu Ser Arg Arg Phe 
                725                 730                 735     


Asn Tyr Ile Val Arg Tyr Ala Asp Pro Lys Lys Ile Arg Lys Cys Thr 
            740                 745                 750         


Glu Asn Asn Glu Leu Leu Lys Phe Ala Phe Lys Asp Val Pro Asp Ser 
        755                 760                 765             


Gln Val Asp Arg Tyr Tyr Asn Ile Cys Val Thr Asn Lys Ile Thr Asn 
    770                 775                 780                 


Ala Thr Arg Glu Glu Lys Ile Glu Arg Leu Val Asp Ile Ile Lys Ser 
785                 790                 795                 800 


Met Asn Leu Ser Lys Val Ala Thr Val Lys Gln Arg Asp Lys Gln Asp 
                805                 810                 815     


Asn Val Glu Lys Gln Lys Gln Leu Ala Ile Met Ser Leu Tyr Leu Asn 
            820                 825                 830         


Ile Leu Tyr Gln Ile Ala Lys Asn Leu Val Tyr Val Asn Ser Arg Tyr 
        835                 840                 845             


Val Met Ala Phe His Ser Leu Glu Arg Asp Ser Gln Met Leu Phe Asp 
    850                 855                 860                 


Ala Tyr Tyr Asp Val Lys Arg Gly Tyr Cys Asp Leu Ser Thr Val Leu 
865                 870                 875                 880 


Leu Phe Gly Val Asp Asp Leu Gln Asn Arg Asn Arg Gly Ser Tyr Lys 
                885                 890                 895     


Tyr Leu Arg Asp Asn Arg Arg Ser Asn Lys Asp Val Ile Glu Thr Phe 
            900                 905                 910         


Gly Asp Phe Lys Gly Lys Val Ser Lys Val Val Glu Lys Lys Asn Gln 
        915                 920                 925             


Gly Leu Thr Asn Glu Ile Tyr Asp Ser Leu Cys Asn Val Ala Gly Thr 
    930                 935                 940                 


Thr Lys Thr Glu Val Gln Asn Glu Ile Lys Ser Ile Leu Lys Ser Asn 
945                 950                 955                 960 


Gly Leu Asp Glu Ser Ala Ser Ser Tyr Leu Ser His Lys Leu Val Asn 
                965                 970                 975     


Lys Val His Ser Tyr Lys Tyr Leu Lys Gln Asn Leu Asp Cys Ala Asp 
            980                 985                 990         


Asn Thr Met Ile Asn Gln Phe Arg  Asn Asn Val Ala His  Leu Asn Thr 
        995                 1000                 1005             


Ile Arg  Asn Met Asp Gly Ile  Glu Asn Val Thr Gly  Ile Thr Ser 
    1010                 1015                 1020             


Tyr Phe  Gln Ile Tyr His Tyr  Leu Met Gln Lys Ala  Leu Tyr Lys 
    1025                 1030                 1035             


Glu Phe  Lys Lys Cys Arg Glu  Asn Ala Val Arg Lys  Trp Ile Pro 
    1040                 1045                 1050             


Tyr Ile  Thr Glu Asn Ala Glu  Pro Lys Tyr Val Tyr  Trp Asn Lys 
    1055                 1060                 1065             


Lys Glu  Gln Gln Glu Val Glu  Val Ser Phe Asn Pro  Lys Ile Phe 
    1070                 1075                 1080             


Gly Tyr  Met Glu Asn Ile Lys  Asn His Ser Asn Thr  Tyr Cys Lys 
    1085                 1090                 1095             


Asp Phe  Val Lys Ala Leu Cys  Ala Pro Phe Ala Tyr  Asn Leu Pro 
    1100                 1105                 1110             


Arg Phe  Lys Asn Leu Ser Ile  Glu Glu Leu Phe Asp  Met His Glu 
    1115                 1120                 1125             


Leu Ser  Glu Glu Pro Lys Glu  Ser Met Lys Leu Thr  Asp 
    1130                 1135                 1140     


<210>  2809
<211>  946
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2809

Met Lys Lys Phe Ser Asn Ile Lys Arg Leu Gly Val Lys Ser Val His 
1               5                   10                  15      


Tyr Ala Asn Asn Thr Val Ile Val Glu Asp His Phe Ser Lys Asn Thr 
            20                  25                  30          


Asn Ile Leu Phe Thr Ala Glu Tyr Glu Asn Ile Asp Asp Leu Lys Ser 
        35                  40                  45              


Cys Thr Asn Ile Asp Lys Thr Ala Glu Asn Lys Gly Val Arg Phe Thr 
    50                  55                  60                  


Asp Leu Lys Asn Lys Asn Gly Phe Glu Leu Ser Ala Met Ala Gln Lys 
65                  70                  75                  80  


Gln Ile Leu Lys Ser Arg Val Asn Arg Val Lys Lys Val Ser Tyr Thr 
                85                  90                  95      


Gln Glu Leu Phe Asp Ile Thr Thr Asp Asn Asn Ile Glu Val Gln Ile 
            100                 105                 110         


Phe Ser Asn Leu Glu Asp Val Lys Lys Val Ile Ala Pro Tyr Tyr Asn 
        115                 120                 125             


Asn Val Ala Tyr Ala Ile Asn Ser Leu Tyr Arg Asp Ile Ser Asn Asp 
    130                 135                 140                 


Asp Ser Tyr Gly Phe Asp Lys Ile Gly Ser Ile Pro Val Asp Ala Asp 
145                 150                 155                 160 


Trp Tyr Asn Phe Leu Lys Asp Ala Pro Asp Lys Lys Glu Lys Trp Thr 
                165                 170                 175     


Thr Tyr Ile Ile Pro Ser Tyr Lys Lys Val Ile Ala Arg Phe Gly Ile 
            180                 185                 190         


Gln Met Glu Lys Asn Gln Gln Val Asn Phe Cys Lys Cys Leu Glu Tyr 
        195                 200                 205             


Val Ala Ile Arg Asn Gly Leu Phe Val Lys Phe Lys Asp Glu Lys Val 
    210                 215                 220                 


Asp Pro Asp Lys Leu Leu Asn Lys Lys Ile Gln Glu Lys Leu Asp Lys 
225                 230                 235                 240 


Leu Ile Ser Asp Lys Glu Val Asn Asp Lys Leu Phe Glu Leu Ala Lys 
                245                 250                 255     


Thr Pro Val Ser Glu Phe Cys Ala Glu Ala Asn Ala Ile Pro Leu Tyr 
            260                 265                 270         


Arg Tyr Ala Phe Ile Gly Gln Lys Gly Lys Arg Ile Glu Lys Ile Val 
        275                 280                 285             


Leu Asp Lys Leu Glu Glu Asn Glu Ile Leu Ser Ser Leu Val Arg Lys 
    290                 295                 300                 


Ile Asp Glu Asn Glu Thr Thr Tyr Asn Tyr Leu Arg Leu Leu Ser Ala 
305                 310                 315                 320 


Ile Arg Gln Tyr Val Val His Asn Ser Arg Lys Val Arg Ile Asp Lys 
                325                 330                 335     


Asn Val Phe Ile Asn Asp Thr Ala Lys Arg Asp Val Glu Glu Phe Ala 
            340                 345                 350         


Lys Gln Phe Gln Lys Asn Asn Tyr Lys Tyr Phe Cys Ile Leu Lys Glu 
        355                 360                 365             


Leu Tyr Ser Asp Ser Asp Ile Leu Glu Gln Phe Phe Asp Tyr Thr Val 
    370                 375                 380                 


Phe Asp Glu Ala Arg Asn Leu Lys Ile Ser Ile Asp Lys Ile Lys Lys 
385                 390                 395                 400 


Gly Ile Thr Ala Asn Ile Asp Ile Ser Ala Asp Val Glu Pro Asp Lys 
                405                 410                 415     


Leu Ser Glu Tyr Ala Asn Lys Phe Arg Thr Val Thr Met Phe Ala Leu 
            420                 425                 430         


Thr Lys Tyr Leu Lys Glu Asn Val Gly Glu Ile Glu Asp Phe Leu Ala 
        435                 440                 445             


Asn Ile Lys Val Cys Ser Ser Asp Glu Glu Lys Ala Gly Val Tyr Glu 
    450                 455                 460                 


Gln Lys Ala Lys Glu Phe Ile Thr Lys Phe Asp Ser Phe Lys Asp Ile 
465                 470                 475                 480 


Arg Ser Val Val Lys Lys His Leu Gly Thr Gln Lys Val Asn Glu Lys 
                485                 490                 495     


Phe Asp Phe Tyr Pro Ser Asp Ile Asn Phe Gly Arg Asp Ser Asn Val 
            500                 505                 510         


Phe Phe Asn Met Leu Tyr Val Met Ser Lys Phe Leu Thr Val Asn Glu 
        515                 520                 525             


Ala Arg Ile Met Phe Gln Lys Ile Lys Ser Lys Tyr Asp Ser Val Lys 
    530                 535                 540                 


Ser Leu Leu Lys Ile Ala Glu Leu Thr Gly Val Thr Leu Ser Asp Asn 
545                 550                 555                 560 


Leu Phe Asp Arg Phe Arg Met Ile Phe Asp Lys Glu Arg Val Asp Glu 
                565                 570                 575     


Tyr Gln Lys Gln Leu Ile Val Leu Gln Ser Ile Arg Thr Arg Asn Gly 
            580                 585                 590         


Val Ser Gln Glu Gly Phe Ala Lys Glu Leu Lys Arg Ile Phe Asp Met 
        595                 600                 605             


Phe Lys Lys Asp Asp Ile Ser Tyr Glu Glu Phe Glu Lys Glu Leu Ser 
    610                 615                 620                 


Leu Asp Glu Asn Gln Asn Glu Ile Lys Asn Lys Ser Phe Lys Leu Lys 
625                 630                 635                 640 


Pro Leu Lys Ser Tyr Leu Arg Asn Asp Val Tyr Lys Ser Lys Gln Tyr 
                645                 650                 655     


Gln Tyr Ile Ser Ser Phe Ala Ser Ala Gly Ile Cys Gln Lys Ile Met 
            660                 665                 670         


Glu Asn Lys Asp Ile Val Ala Phe Val Leu Asn Gly Met Leu Tyr Gln 
        675                 680                 685             


Glu Gly Lys Leu Ser Met Pro Met His Lys Tyr Val Ala Lys Val Tyr 
    690                 695                 700                 


His Asp Phe Arg Arg Glu Lys Ile Asp Glu Asn Ser Ala Asn Tyr Leu 
705                 710                 715                 720 


Leu Asp Gln Asn Gln Ile Ser Ser Leu Val Asn Ser Leu Cys Asp Leu 
                725                 730                 735     


Lys Leu Glu Asn Ile Ile Glu Ala Ile Phe Lys Glu Ser Arg Val Asn 
            740                 745                 750         


Tyr Lys Ala Leu Val Arg Leu Tyr Leu Asn Ile Cys Tyr Leu Phe Val 
        755                 760                 765             


Lys Asn Ile Ile Ser Leu Asn Ser Thr Tyr Leu Ile Gln Phe Gln Asp 
    770                 775                 780                 


Tyr Glu Asn Ile Tyr Lys Gln Leu His Leu Glu Asp Leu Met Asp Ile 
785                 790                 795                 800 


Thr Tyr Asp Phe Gly Val Leu Asn Asn Phe Val Glu Asn Ala Pro Asn 
                805                 810                 815     


Lys Lys Cys Arg Ser Tyr Met Gln Leu Gln Thr Leu Leu Glu Lys Asp 
            820                 825                 830         


Tyr Ile Lys Asp Tyr Ile Tyr Thr Pro Glu Tyr Gln Val Leu Gln Asp 
        835                 840                 845             


Arg Tyr Arg Asn Leu Val Val His Ser Ser Leu Leu Phe Gly Leu Asp 
    850                 855                 860                 


Lys Ile Asp Phe Asp Phe Gly Glu Val Gln Asn Ile Ser Ser Tyr Phe 
865                 870                 875                 880 


Ala Ile Tyr Gln Thr Leu Val Gln Arg Leu Val Glu Gln Asp Ala Arg 
                885                 890                 895     


Glu Val Trp Gly Glu Lys Phe Asp Glu Tyr Phe Ala Leu Asn Asn Gly 
            900                 905                 910         


Lys Thr Tyr Ser Thr Lys Leu Cys Ile Ala Leu Asn Met Pro Tyr Ala 
        915                 920                 925             


Tyr Asn Ile Ser Arg Phe Asn Asn Asn Thr Ile Glu Lys Tyr Ser Asn 
    930                 935                 940                 


Lys Arg 
945     


<210>  2810
<211>  960
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2810

Met Ala Lys Lys Leu Asn Ala Lys Glu Lys Arg Leu Leu Ser Gln Gln 
1               5                   10                  15      


Ala Gln Lys Asp Lys Tyr Lys Lys Met Glu Glu Glu Arg Gln Ala Ala 
            20                  25                  30          


Glu Gln Ala Arg Leu Ala Glu Glu Ala Arg Gln Lys Ala Glu Thr Glu 
        35                  40                  45              


Arg Lys Lys Lys Glu Ala Leu Glu Lys Glu Ala Arg Glu Lys Leu Glu 
    50                  55                  60                  


Lys Glu Leu Leu Glu Lys Asn Pro Ser Leu Lys Lys Val Lys Lys Ser 
65                  70                  75                  80  


Lys Ala Lys Ala Ala Gly Leu Lys Ser Thr Phe Ala Ile Gly Asn Glu 
                85                  90                  95      


Leu Leu Met Thr Ser Phe Gly Lys Gly Asn Glu Ala Val Pro Glu His 
            100                 105                 110         


Tyr Ile Phe Glu Asn Gly Met Ile Ser Met Gln Asn Pro Pro Ala Phe 
        115                 120                 125             


Asp Val Glu Asn Arg Gly Thr Ser Phe Ser Ile Ala Gly Lys Asn Ala 
    130                 135                 140                 


Met Asn Ala Ile Ala Asp Asp Pro Arg Arg Thr Ser Lys Lys Val Ile 
145                 150                 155                 160 


Gly Glu Asp Leu Ile Gly Ala Lys Ser Ala Leu Glu Lys Arg Tyr Phe 
                165                 170                 175     


Gly Lys Thr Phe Glu Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
            180                 185                 190         


Leu Asp Ile Glu Lys Ile Leu Ser Lys His Ile Asn Asn Ile Val Phe 
        195                 200                 205             


Ser Ile Asn Asn Ile Arg Gly Ile Ala Asp Pro Glu Arg Asp Asp Leu 
    210                 215                 220                 


Ile Gly Tyr Met Ser Leu Arg Asp Ser Tyr Glu Tyr Phe Met Asp Glu 
225                 230                 235                 240 


Lys Asn Glu Lys Arg Lys Val Leu Arg Glu Ser Tyr Arg Lys Leu Phe 
                245                 250                 255     


Lys Ser Ser Arg Leu Ser Tyr Phe Gly Ser Ala Phe Tyr Val Glu Lys 
            260                 265                 270         


Gln Ser Thr Gln Lys Lys Lys Ser Gly Gln Lys Asn Phe Glu Leu Arg 
        275                 280                 285             


Asn Glu Lys Asp Cys Tyr Tyr Met Leu Ala Leu Leu Gly Glu Leu Arg 
    290                 295                 300                 


Gln Val Leu Ala His Ser Ser Ala Gln Lys Gln Gly Lys Glu Gln Thr 
305                 310                 315                 320 


Glu Ala Arg Ser Ser Val Tyr Asn Leu Arg Thr Val Gly Asn Asn Asp 
                325                 330                 335     


Met Arg Lys Ile Leu Asn Ser Leu Tyr Ala Glu Arg Val Asp Ala Leu 
            340                 345                 350         


Asn Glu Asn Phe Met Asn Tyr Ala Lys Lys Asp Leu Thr Ile Leu Phe 
        355                 360                 365             


Gly Ile Met Asp Ala Ser Ser Tyr Glu Lys Lys Ala Glu Ile Ala Arg 
    370                 375                 380                 


Asp Phe Tyr Asp Phe Thr Val Arg Lys Ser Tyr Lys Asn Ile Gly Phe 
385                 390                 395                 400 


Ser Ile Lys Lys Ile Arg Glu Arg Met Met Asp Cys Phe Phe Ala Asn 
                405                 410                 415     


Val Lys Glu Ile Thr Pro Asp Ser Pro Asp Phe Gln Ser Val Arg Gln 
            420                 425                 430         


Lys Phe Tyr Lys Ile Leu Asp Phe Leu Leu Phe Thr Tyr Tyr Lys Asp 
        435                 440                 445             


Asn Lys Glu Glu Thr Lys Lys Ile Ile Ala Ala Leu Arg Ala Ser Leu 
    450                 455                 460                 


Thr Glu Leu Glu Lys Glu Leu Phe Tyr Gln Lys Gln Ala Asn Ile Leu 
465                 470                 475                 480 


Trp Asn Lys Met Gln Met Val Val Thr Glu Gln Ile Tyr Pro Arg Thr 
                485                 490                 495     


Lys Gly Ser Ala Ile Gln Asn Leu Ile Ala Asp Pro Glu Ile Ser Ala 
            500                 505                 510         


Asp Met Leu Lys Gly Val Met Ile Thr Pro Glu Ser Val Asp Tyr Phe 
        515                 520                 525             


Ser Lys Met Ile Tyr Leu Leu Thr Leu Phe Ile Asp Gly Lys Glu Ile 
    530                 535                 540                 


Asn Asp Leu Leu Thr Thr Met Ile Asn Lys Phe Glu Asn Ile Ala Ser 
545                 550                 555                 560 


Phe Val Ser Val Leu Lys Asp Arg Gly Leu Pro Cys Asn Phe Arg Asn 
                565                 570                 575     


Asp Tyr Ser Val Phe Asn Asn Ala Leu Lys Ile Ser Ala Glu Leu Arg 
            580                 585                 590         


Glu Ile Asn Ser Phe Ala Arg Met Glu Lys Ala Thr Pro Gly Ala Lys 
        595                 600                 605             


Lys Gln Met Phe Leu Asp Ala Ala Ile Ile Leu Gly Ser Asn Glu Ser 
    610                 615                 620                 


Ala Glu Glu Leu Ser Glu Tyr Phe Asp Glu Met Leu Asp Lys Gln Lys 
625                 630                 635                 640 


Gly Lys Arg Thr Pro Gly Gly Lys Lys Asp Met Gly Phe Arg Asn Phe 
                645                 650                 655     


Leu Ile Lys Asn Val Ile Glu Ser Asp Arg Phe His Tyr Leu Ile Arg 
            660                 665                 670         


Tyr Gly His Pro Leu His Ile Arg Lys Leu Ala Glu Asn Lys Asn Val 
        675                 680                 685             


Ile Ala Phe Val Leu Lys Gln Ile Pro Glu Pro Gln Ile Asp Arg Tyr 
    690                 695                 700                 


Cys Lys Ile Cys Ala Leu Pro Ala Glu Ser Asn Phe Ala Gln Lys Ile 
705                 710                 715                 720 


Leu Arg Leu Thr Asp Leu Ile Ala Glu Met Asn Phe Arg Gln Phe Glu 
                725                 730                 735     


Asn Val Arg Gln Thr Glu Lys Asn Glu Gln Lys Gln Ile Leu Gln Gly 
            740                 745                 750         


Ile Leu Ser Leu Tyr Leu Thr Val Leu Tyr Leu Leu Thr Lys Asn Leu 
        755                 760                 765             


Val Tyr Val Asn Ser Arg Tyr Phe Leu Ala Phe His Cys Leu Glu Arg 
    770                 775                 780                 


Asp Thr Glu Leu Leu Gly Ser Gln Ala Gly His Lys Asn Ala Glu Lys 
785                 790                 795                 800 


Gln Leu Ile Ala Ser Tyr Ser Ala Leu Thr Gln Gln Phe Leu Asp Glu 
                805                 810                 815     


Gly Lys Leu Asn Arg His Ala Arg Glu Tyr Leu Thr Val Asn Ile Gln 
            820                 825                 830         


Asn Ser Asp Asp Trp Thr Ile Ala Gln Tyr Arg Asn Asn Ala Ala His 
        835                 840                 845             


Leu Asn Ala Ile Arg Asn Ala His Leu Tyr Ile Arg Glu Met Lys Ser 
    850                 855                 860                 


Val Arg Ser Tyr Phe Glu Leu Tyr His Tyr Leu Thr Gln Arg Ala Leu 
865                 870                 875                 880 


Leu Asp Lys Tyr Glu Asn Val Pro Tyr His Pro Gln Val Asn Glu Lys 
                885                 890                 895     


Thr Leu Lys Tyr Phe Glu Leu Leu Lys Glu Asn Gly Trp Tyr Cys Lys 
            900                 905                 910         


Asp Phe Val Lys Ala Leu Asn Val Pro Phe Gly Tyr Asn Leu Pro Arg 
        915                 920                 925             


Tyr Lys Asn Leu Ser Ile Asp Ala Leu Phe Asp Lys Asp Arg Pro Gln 
    930                 935                 940                 


Glu Glu Asp Glu Asn His Leu Tyr Thr Cys Gln Asn Ile Lys Lys Ser 
945                 950                 955                 960 


<210>  2811
<211>  946
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2811

Met Lys Lys Phe Ser Asn Ile Lys Arg Leu Gly Val Lys Ser Val His 
1               5                   10                  15      


Tyr Ala Asn Asn Thr Val Ile Val Glu Asp His Phe Ser Lys Asn Thr 
            20                  25                  30          


Asn Ile Leu Phe Thr Ala Glu Tyr Glu Asn Ile Asp Asp Leu Lys Ser 
        35                  40                  45              


Cys Thr Asn Ile Asp Lys Thr Ala Glu Asn Lys Gly Val Arg Phe Thr 
    50                  55                  60                  


Asp Leu Lys Asn Lys Asn Gly Phe Glu Leu Ser Ala Met Ala Gln Lys 
65                  70                  75                  80  


Gln Ile Leu Lys Ser Arg Val Asn Arg Val Lys Lys Val Ser Tyr Thr 
                85                  90                  95      


Gln Glu Leu Phe Asp Ile Thr Thr Asp Asn Asn Ile Glu Val Gln Ile 
            100                 105                 110         


Phe Ser Asn Leu Glu Asp Val Lys Lys Val Ile Ala Pro Tyr Tyr Asn 
        115                 120                 125             


Asn Val Ala Tyr Ala Ile Asn Ser Leu Tyr Arg Asp Ile Ser Asn Asp 
    130                 135                 140                 


Asp Ser Tyr Gly Phe Asp Lys Ile Gly Ser Ile Pro Val Asp Ala Asp 
145                 150                 155                 160 


Trp Tyr Asn Phe Leu Lys Asp Ala Pro Asp Lys Lys Glu Lys Trp Thr 
                165                 170                 175     


Thr Tyr Ile Ile Pro Ser Tyr Lys Lys Val Ile Ala Arg Phe Gly Ile 
            180                 185                 190         


Gln Met Glu Lys Asn Gln Gln Val Asn Phe Cys Lys Cys Leu Glu Tyr 
        195                 200                 205             


Val Ala Ile Arg Asn Gly Leu Phe Val Lys Phe Lys Asp Glu Lys Val 
    210                 215                 220                 


Asp Pro Asp Lys Leu Leu Asn Lys Lys Ile Gln Glu Lys Leu Asp Lys 
225                 230                 235                 240 


Leu Ile Ser Asp Lys Glu Val Asn Asp Lys Leu Phe Glu Leu Ala Lys 
                245                 250                 255     


Thr Pro Val Ser Glu Phe Cys Ala Glu Ala Asn Ala Ile Pro Leu Tyr 
            260                 265                 270         


Arg Tyr Ala Phe Ile Gly Gln Lys Gly Lys Arg Ile Glu Lys Ile Val 
        275                 280                 285             


Leu Asp Lys Leu Glu Glu Asn Glu Ile Leu Ser Ser Leu Val Arg Lys 
    290                 295                 300                 


Ile Asp Glu Asn Glu Thr Thr Tyr Asn Tyr Leu Arg Leu Leu Ser Ala 
305                 310                 315                 320 


Ile Arg Gln Tyr Val Val His Asn Ser Arg Lys Val Arg Ile Asp Lys 
                325                 330                 335     


Asn Val Phe Ile Asn Asp Thr Ala Lys Arg Asp Val Glu Glu Phe Ala 
            340                 345                 350         


Lys Gln Phe Gln Lys Asn Asn Tyr Lys Tyr Phe Cys Ile Leu Lys Glu 
        355                 360                 365             


Leu Tyr Ser Asp Ser Asp Ile Leu Glu Gln Phe Phe Asp Tyr Thr Val 
    370                 375                 380                 


Phe Asp Glu Ala Arg Asn Leu Lys Ile Ser Ile Asp Lys Ile Lys Lys 
385                 390                 395                 400 


Gly Ile Thr Ala Asn Ile Asp Ile Ser Ala Asp Val Glu Pro Asp Lys 
                405                 410                 415     


Leu Ser Glu Tyr Ala Asn Lys Phe Arg Thr Val Thr Met Phe Ala Leu 
            420                 425                 430         


Thr Lys Tyr Leu Lys Glu Asn Val Gly Glu Ile Glu Asp Phe Leu Ala 
        435                 440                 445             


Asn Ile Lys Val Cys Ser Ser Asp Glu Glu Lys Ala Gly Val Tyr Glu 
    450                 455                 460                 


Gln Lys Ala Lys Glu Phe Ile Thr Lys Phe Asp Ser Phe Lys Asp Ile 
465                 470                 475                 480 


Arg Ser Val Val Lys Lys His Leu Gly Thr Gln Lys Val Asn Glu Lys 
                485                 490                 495     


Phe Asp Phe Tyr Pro Ser Asp Ile Asn Phe Gly Arg Asp Ser Asn Val 
            500                 505                 510         


Phe Phe Asn Met Leu Tyr Val Met Ser Lys Phe Leu Thr Val Asn Glu 
        515                 520                 525             


Ala Arg Ile Met Phe Gln Lys Ile Lys Ser Lys Tyr Asp Ser Val Lys 
    530                 535                 540                 


Ser Leu Leu Lys Ile Ala Glu Leu Thr Gly Val Thr Leu Ser Asp Asn 
545                 550                 555                 560 


Leu Phe Asp Arg Phe Arg Met Ile Phe Asp Lys Glu Arg Val Asp Glu 
                565                 570                 575     


Tyr Gln Lys Gln Leu Ile Val Leu Gln Ser Ile Arg Thr Arg Asn Gly 
            580                 585                 590         


Val Ser Gln Glu Gly Phe Ala Lys Glu Leu Lys Arg Ile Phe Asp Met 
        595                 600                 605             


Phe Lys Lys Asp Asp Ile Ser Tyr Glu Glu Phe Glu Lys Glu Leu Ser 
    610                 615                 620                 


Leu Asp Glu Asn Gln Asn Glu Ile Lys Asn Lys Ser Phe Lys Leu Lys 
625                 630                 635                 640 


Pro Leu Lys Ser Tyr Leu Arg Asn Asp Val Tyr Lys Ser Lys Gln Tyr 
                645                 650                 655     


Gln Tyr Ile Ser Ser Phe Ala Ser Ala Gly Ile Cys Gln Lys Ile Met 
            660                 665                 670         


Glu Asn Lys Asp Ile Val Ala Phe Val Leu Asn Gly Met Leu Tyr Gln 
        675                 680                 685             


Glu Gly Lys Leu Ser Met Pro Met His Lys Tyr Val Ala Lys Val Tyr 
    690                 695                 700                 


His Asp Phe Arg Arg Glu Lys Ile Asp Glu Asn Ser Ala Asn Tyr Leu 
705                 710                 715                 720 


Leu Asp Gln Asn Gln Ile Ser Ser Leu Val Asn Ser Leu Cys Asp Leu 
                725                 730                 735     


Lys Leu Glu Asn Ile Ile Glu Ala Ile Phe Lys Glu Ser Arg Val Asn 
            740                 745                 750         


Tyr Lys Ala Leu Val Arg Leu Tyr Leu Asn Ile Cys Tyr Leu Phe Val 
        755                 760                 765             


Lys Asn Ile Ile Ser Leu Asn Ser Thr Tyr Leu Ile Gln Phe Gln Asp 
    770                 775                 780                 


Tyr Glu Asn Ile Tyr Lys Gln Leu His Leu Glu Asp Leu Met Asp Ile 
785                 790                 795                 800 


Thr Tyr Asp Phe Gly Val Leu Asn Asn Phe Val Glu Asn Ala Pro Asn 
                805                 810                 815     


Lys Lys Cys Arg Ser Tyr Met Gln Leu Gln Thr Leu Leu Glu Lys Asp 
            820                 825                 830         


Tyr Ile Lys Asp Tyr Ile Tyr Thr Pro Glu Tyr Gln Val Leu Gln Asp 
        835                 840                 845             


Arg Tyr Arg Asn Leu Val Val His Ser Ser Leu Leu Phe Gly Leu Asp 
    850                 855                 860                 


Lys Ile Asp Phe Asp Phe Gly Glu Val Gln Asn Ile Ser Ser Tyr Phe 
865                 870                 875                 880 


Ala Ile Tyr Gln Thr Leu Val Gln Arg Leu Val Glu Gln Asp Ala Arg 
                885                 890                 895     


Glu Val Trp Gly Glu Lys Phe Asp Glu Tyr Phe Ala Leu Asn Asn Gly 
            900                 905                 910         


Lys Thr Tyr Ser Thr Lys Leu Cys Ile Ala Leu Asn Met Pro Tyr Ala 
        915                 920                 925             


Tyr Asn Ile Ser Arg Phe Asn Asn Asn Thr Ile Glu Lys Tyr Ser Asn 
    930                 935                 940                 


Lys Arg 
945     


<210>  2812
<211>  960
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2812

Met Ala Lys Lys Leu Asn Ala Lys Glu Lys Arg Leu Leu Ser Gln Gln 
1               5                   10                  15      


Ala Gln Lys Asp Lys Tyr Lys Lys Met Glu Glu Glu Arg Gln Ala Ala 
            20                  25                  30          


Glu Gln Ala Arg Leu Ala Glu Glu Ala Arg Gln Lys Ala Glu Thr Glu 
        35                  40                  45              


Arg Lys Lys Lys Glu Ala Leu Glu Lys Glu Ala Arg Glu Lys Leu Glu 
    50                  55                  60                  


Lys Glu Leu Leu Glu Lys Asn Pro Ser Leu Lys Lys Val Lys Lys Ser 
65                  70                  75                  80  


Lys Ala Lys Ala Ala Gly Leu Lys Ser Thr Phe Ala Ile Gly Asn Glu 
                85                  90                  95      


Leu Leu Met Thr Ser Phe Gly Lys Gly Asn Glu Ala Val Pro Glu His 
            100                 105                 110         


Tyr Ile Phe Glu Asn Gly Met Ile Ser Met Gln Asn Pro Pro Ala Phe 
        115                 120                 125             


Asp Val Glu Asn Arg Gly Thr Ser Phe Ser Ile Ala Gly Lys Asn Ala 
    130                 135                 140                 


Met Asn Ala Ile Ala Asp Asp Pro Arg Arg Thr Ser Lys Lys Val Ile 
145                 150                 155                 160 


Gly Glu Asp Leu Ile Gly Ala Lys Ser Ala Leu Glu Lys Arg Tyr Phe 
                165                 170                 175     


Gly Lys Thr Phe Glu Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
            180                 185                 190         


Leu Asp Ile Glu Lys Ile Leu Ser Lys His Ile Asn Asn Ile Val Phe 
        195                 200                 205             


Ser Ile Asn Asn Ile Arg Gly Ile Ala Asp Pro Glu Arg Asp Asp Leu 
    210                 215                 220                 


Ile Gly Tyr Met Ser Leu Arg Asp Ser Tyr Glu Tyr Phe Met Asp Glu 
225                 230                 235                 240 


Lys Asn Glu Lys Arg Lys Val Leu Arg Glu Ser Tyr Arg Lys Leu Phe 
                245                 250                 255     


Lys Ser Ser Arg Leu Ser Tyr Phe Gly Ser Ala Phe Tyr Val Glu Lys 
            260                 265                 270         


Gln Ser Thr Gln Lys Lys Lys Ser Gly Gln Lys Asn Phe Glu Leu Arg 
        275                 280                 285             


Asn Glu Lys Asp Cys Tyr Tyr Met Leu Ala Leu Leu Gly Glu Leu Arg 
    290                 295                 300                 


Gln Val Leu Ala His Ser Ser Ala Gln Lys Gln Gly Lys Glu Gln Thr 
305                 310                 315                 320 


Glu Ala Arg Ser Ser Val Tyr Asn Leu Arg Thr Val Gly Asn Asn Asp 
                325                 330                 335     


Met Arg Lys Ile Leu Asn Ser Leu Tyr Ala Glu Arg Val Asp Ala Leu 
            340                 345                 350         


Asn Glu Asn Phe Met Asn Tyr Ala Lys Lys Asp Leu Thr Ile Leu Phe 
        355                 360                 365             


Gly Ile Met Asp Ala Ser Ser Tyr Glu Lys Lys Ala Glu Ile Ala Arg 
    370                 375                 380                 


Asp Phe Tyr Asp Phe Thr Val Arg Lys Ser Tyr Lys Asn Ile Gly Phe 
385                 390                 395                 400 


Ser Ile Lys Lys Ile Arg Glu Arg Met Met Asp Cys Phe Phe Ala Asn 
                405                 410                 415     


Val Lys Glu Ile Thr Pro Asp Ser Pro Asp Phe Gln Ser Val Arg Gln 
            420                 425                 430         


Lys Phe Tyr Lys Ile Leu Asp Phe Leu Leu Phe Thr Tyr Tyr Lys Asp 
        435                 440                 445             


Asn Lys Glu Glu Thr Lys Lys Ile Ile Ala Ala Leu Arg Ala Ser Leu 
    450                 455                 460                 


Thr Glu Leu Glu Lys Glu Leu Phe Tyr Gln Lys Gln Ala Asn Ile Leu 
465                 470                 475                 480 


Trp Asn Lys Met Gln Met Val Val Thr Glu Gln Ile Tyr Pro Arg Thr 
                485                 490                 495     


Lys Gly Ser Ala Ile Gln Asn Leu Ile Ala Asp Pro Glu Ile Ser Ala 
            500                 505                 510         


Asp Met Leu Lys Gly Val Met Ile Thr Pro Glu Ser Val Asp Tyr Phe 
        515                 520                 525             


Ser Lys Met Ile Tyr Leu Leu Thr Leu Phe Ile Asp Gly Lys Glu Ile 
    530                 535                 540                 


Asn Asp Leu Leu Thr Thr Met Ile Asn Lys Phe Glu Asn Ile Ala Ser 
545                 550                 555                 560 


Phe Val Ser Val Leu Lys Asp Arg Gly Leu Pro Cys Asn Phe Arg Asn 
                565                 570                 575     


Asp Tyr Ser Val Phe Asn Asn Ala Leu Lys Ile Ser Ala Glu Leu Arg 
            580                 585                 590         


Glu Ile Asn Ser Phe Ala Arg Met Glu Lys Ala Thr Pro Gly Ala Lys 
        595                 600                 605             


Lys Gln Met Phe Leu Asp Ala Ala Ile Ile Leu Gly Ser Asn Glu Ser 
    610                 615                 620                 


Ala Glu Glu Leu Ser Glu Tyr Phe Asp Glu Met Leu Asp Lys Gln Lys 
625                 630                 635                 640 


Gly Lys Arg Thr Pro Gly Gly Lys Lys Asp Met Gly Phe Arg Asn Phe 
                645                 650                 655     


Leu Ile Lys Asn Val Ile Glu Ser Asp Arg Phe His Tyr Leu Ile Arg 
            660                 665                 670         


Tyr Gly His Pro Leu His Ile Arg Lys Leu Ala Glu Asn Lys Asn Val 
        675                 680                 685             


Ile Ala Phe Val Leu Lys Gln Ile Pro Glu Pro Gln Ile Asp Arg Tyr 
    690                 695                 700                 


Cys Lys Ile Cys Ala Leu Pro Ala Glu Ser Asn Phe Ala Gln Lys Ile 
705                 710                 715                 720 


Leu Arg Leu Thr Asp Leu Ile Ala Glu Met Asn Phe Arg Gln Phe Glu 
                725                 730                 735     


Asn Val Arg Gln Thr Glu Lys Asn Glu Gln Lys Gln Ile Leu Gln Gly 
            740                 745                 750         


Ile Leu Ser Leu Tyr Leu Thr Val Leu Tyr Leu Leu Thr Lys Asn Leu 
        755                 760                 765             


Val Tyr Val Asn Ser Arg Tyr Phe Leu Ala Phe His Cys Leu Glu Arg 
    770                 775                 780                 


Asp Thr Glu Leu Leu Gly Ser Gln Ala Gly His Lys Asn Ala Glu Lys 
785                 790                 795                 800 


Gln Leu Ile Ala Ser Tyr Ser Ala Leu Thr Gln Gln Phe Leu Asp Glu 
                805                 810                 815     


Gly Lys Leu Asn Arg His Ala Arg Glu Tyr Leu Thr Val Asn Ile Gln 
            820                 825                 830         


Asn Ser Asp Asp Trp Thr Ile Ala Gln Tyr Arg Asn Asn Ala Ala His 
        835                 840                 845             


Leu Asn Ala Ile Arg Asn Ala His Leu Tyr Ile Arg Glu Met Lys Ser 
    850                 855                 860                 


Val Arg Ser Tyr Phe Glu Leu Tyr His Tyr Leu Thr Gln Arg Ala Leu 
865                 870                 875                 880 


Leu Asp Lys Tyr Glu Asn Val Pro Tyr His Pro Gln Val Asn Glu Lys 
                885                 890                 895     


Thr Leu Lys Tyr Phe Glu Leu Leu Lys Glu Asn Gly Trp Tyr Cys Lys 
            900                 905                 910         


Asp Phe Val Lys Ala Leu Asn Val Pro Phe Gly Tyr Asn Leu Pro Arg 
        915                 920                 925             


Tyr Lys Asn Leu Ser Ile Asp Ala Leu Phe Asp Lys Asp Arg Pro Gln 
    930                 935                 940                 


Glu Glu Asp Glu Asn His Leu Tyr Thr Cys Gln Asn Ile Lys Lys Ser 
945                 950                 955                 960 


<210>  2813
<211>  946
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2813

Met Lys Lys Phe Ser Asn Ile Lys Arg Leu Gly Val Lys Ser Val His 
1               5                   10                  15      


Tyr Ala Asn Asn Thr Val Ile Val Glu Asp His Phe Ser Lys Asn Thr 
            20                  25                  30          


Asn Ile Leu Phe Thr Ala Glu Tyr Glu Asn Ile Asp Asp Leu Lys Ser 
        35                  40                  45              


Cys Thr Asn Ile Asp Lys Thr Ala Glu Asn Lys Gly Val Arg Phe Thr 
    50                  55                  60                  


Asp Leu Lys Asn Lys Asn Gly Phe Glu Leu Ser Ala Met Ala Gln Lys 
65                  70                  75                  80  


Gln Ile Leu Lys Ser Arg Val Asn Arg Val Lys Lys Val Ser Tyr Thr 
                85                  90                  95      


Gln Glu Leu Phe Asp Ile Thr Thr Asp Asn Asn Ile Glu Val Gln Ile 
            100                 105                 110         


Phe Ser Asn Leu Glu Asp Val Lys Lys Val Ile Ala Pro Tyr Tyr Asn 
        115                 120                 125             


Asn Val Ala Tyr Ala Ile Asn Ser Leu Tyr Arg Asp Ile Ser Asn Asp 
    130                 135                 140                 


Asp Ser Tyr Gly Phe Asp Lys Ile Gly Ser Ile Pro Val Asp Ala Asp 
145                 150                 155                 160 


Trp Tyr Asn Phe Leu Lys Asp Ala Pro Asp Lys Lys Glu Lys Trp Thr 
                165                 170                 175     


Thr Tyr Ile Ile Pro Ser Tyr Lys Lys Val Ile Ala Arg Phe Gly Ile 
            180                 185                 190         


Gln Met Glu Lys Asn Gln Gln Val Asn Phe Cys Lys Cys Leu Glu Tyr 
        195                 200                 205             


Val Ala Ile Arg Asn Gly Leu Phe Val Lys Phe Lys Asp Glu Lys Val 
    210                 215                 220                 


Asp Pro Asp Lys Leu Leu Asn Lys Lys Ile Gln Glu Lys Leu Asp Lys 
225                 230                 235                 240 


Leu Ile Ser Asp Lys Glu Val Asn Asp Lys Leu Phe Glu Leu Ala Lys 
                245                 250                 255     


Thr Pro Val Ser Glu Phe Cys Ala Glu Ala Asn Ala Ile Pro Leu Tyr 
            260                 265                 270         


Arg Tyr Ala Phe Ile Gly Gln Lys Gly Lys Arg Ile Glu Lys Ile Val 
        275                 280                 285             


Leu Asp Lys Leu Glu Glu Asn Glu Ile Leu Ser Ser Leu Val Arg Lys 
    290                 295                 300                 


Ile Asp Glu Asn Glu Thr Thr Tyr Asn Tyr Leu Arg Leu Leu Ser Ala 
305                 310                 315                 320 


Ile Arg Gln Tyr Val Val His Asn Ser Arg Lys Val Arg Ile Asp Lys 
                325                 330                 335     


Asn Val Phe Ile Asn Asp Thr Ala Lys Arg Asp Val Glu Glu Phe Ala 
            340                 345                 350         


Lys Gln Phe Gln Lys Asn Asn Tyr Lys Tyr Phe Cys Ile Leu Lys Glu 
        355                 360                 365             


Leu Tyr Ser Asp Ser Asp Ile Leu Glu Gln Phe Phe Asp Tyr Thr Val 
    370                 375                 380                 


Phe Asp Glu Ala Arg Asn Leu Lys Ile Ser Ile Asp Lys Ile Lys Lys 
385                 390                 395                 400 


Gly Ile Thr Ala Asn Ile Asp Ile Ser Ala Asp Val Glu Pro Asp Lys 
                405                 410                 415     


Leu Ser Glu Tyr Ala Asn Lys Phe Arg Thr Val Thr Met Phe Ala Leu 
            420                 425                 430         


Thr Lys Tyr Leu Lys Glu Asn Val Gly Glu Ile Glu Asp Phe Leu Ala 
        435                 440                 445             


Asn Ile Lys Val Cys Ser Ser Asp Glu Glu Lys Ala Gly Val Tyr Glu 
    450                 455                 460                 


Gln Lys Ala Lys Glu Phe Ile Thr Lys Phe Asp Ser Phe Lys Asp Ile 
465                 470                 475                 480 


Arg Ser Val Val Lys Lys His Leu Gly Thr Gln Lys Val Asn Glu Lys 
                485                 490                 495     


Phe Asp Phe Tyr Pro Ser Asp Ile Asn Phe Gly Arg Asp Ser Asn Val 
            500                 505                 510         


Phe Phe Asn Met Leu Tyr Val Met Ser Lys Phe Leu Thr Val Asn Glu 
        515                 520                 525             


Ala Arg Ile Met Phe Gln Lys Ile Lys Ser Lys Tyr Asp Ser Val Lys 
    530                 535                 540                 


Ser Leu Leu Lys Ile Ala Glu Leu Thr Gly Val Thr Leu Ser Asp Asn 
545                 550                 555                 560 


Leu Phe Asp Arg Phe Arg Met Ile Phe Asp Lys Glu Arg Val Asp Glu 
                565                 570                 575     


Tyr Gln Lys Gln Leu Ile Val Leu Gln Ser Ile Arg Thr Arg Asn Gly 
            580                 585                 590         


Val Ser Gln Glu Gly Phe Ala Lys Glu Leu Lys Arg Ile Phe Asp Met 
        595                 600                 605             


Phe Lys Lys Asp Asp Ile Ser Tyr Glu Glu Phe Glu Lys Glu Leu Ser 
    610                 615                 620                 


Leu Asp Glu Asn Gln Asn Glu Ile Lys Asn Lys Ser Phe Lys Leu Lys 
625                 630                 635                 640 


Pro Leu Lys Ser Tyr Leu Arg Asn Asp Val Tyr Lys Ser Lys Gln Tyr 
                645                 650                 655     


Gln Tyr Ile Ser Ser Phe Ala Ser Ala Gly Ile Cys Gln Lys Ile Met 
            660                 665                 670         


Glu Asn Lys Asp Ile Val Ala Phe Val Leu Asn Gly Met Leu Tyr Gln 
        675                 680                 685             


Glu Gly Lys Leu Ser Met Pro Met His Lys Tyr Val Ala Lys Val Tyr 
    690                 695                 700                 


His Asp Phe Arg Arg Glu Lys Ile Asp Glu Asn Ser Ala Asn Tyr Leu 
705                 710                 715                 720 


Leu Asp Gln Asn Gln Ile Ser Ser Leu Val Asn Ser Leu Cys Asp Leu 
                725                 730                 735     


Lys Leu Glu Asn Ile Ile Glu Ala Ile Phe Lys Glu Ser Arg Val Asn 
            740                 745                 750         


Tyr Lys Ala Leu Val Arg Leu Tyr Leu Asn Ile Cys Tyr Leu Phe Val 
        755                 760                 765             


Lys Asn Ile Ile Ser Leu Asn Ser Thr Tyr Leu Ile Gln Phe Gln Asp 
    770                 775                 780                 


Tyr Glu Asn Ile Tyr Lys Gln Leu His Leu Glu Asp Leu Met Asp Ile 
785                 790                 795                 800 


Thr Tyr Asp Phe Gly Val Leu Asn Asn Phe Val Glu Asn Ala Pro Asn 
                805                 810                 815     


Lys Lys Cys Arg Ser Tyr Met Gln Leu Gln Thr Leu Leu Glu Lys Asp 
            820                 825                 830         


Tyr Ile Lys Asp Tyr Ile Tyr Thr Pro Glu Tyr Gln Val Leu Gln Asp 
        835                 840                 845             


Arg Tyr Arg Asn Leu Val Val His Ser Ser Leu Leu Phe Gly Leu Asp 
    850                 855                 860                 


Lys Ile Asp Phe Asp Phe Gly Glu Val Gln Asn Ile Ser Ser Tyr Phe 
865                 870                 875                 880 


Ala Ile Tyr Gln Thr Leu Val Gln Arg Leu Val Glu Gln Asp Ala Arg 
                885                 890                 895     


Glu Val Trp Gly Glu Lys Phe Asp Glu Tyr Phe Ala Leu Asn Asn Gly 
            900                 905                 910         


Lys Thr Tyr Ser Thr Lys Leu Cys Ile Ala Leu Asn Met Pro Tyr Ala 
        915                 920                 925             


Tyr Asn Ile Ser Arg Phe Asn Asn Asn Thr Ile Glu Lys Tyr Ser Asn 
    930                 935                 940                 


Lys Arg 
945     


<210>  2814
<211>  960
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2814

Met Ala Lys Lys Leu Asn Ala Lys Glu Lys Arg Leu Leu Ser Gln Gln 
1               5                   10                  15      


Ala Gln Lys Asp Lys Tyr Lys Lys Met Glu Glu Glu Arg Gln Ala Ala 
            20                  25                  30          


Glu Gln Ala Arg Leu Ala Glu Glu Ala Arg Gln Lys Ala Glu Thr Glu 
        35                  40                  45              


Arg Lys Lys Lys Glu Ala Leu Glu Lys Glu Ala Arg Glu Lys Leu Glu 
    50                  55                  60                  


Lys Glu Leu Leu Glu Lys Asn Pro Ser Leu Lys Lys Val Lys Lys Ser 
65                  70                  75                  80  


Lys Ala Lys Ala Ala Gly Leu Lys Ser Thr Phe Ala Ile Gly Asn Glu 
                85                  90                  95      


Leu Leu Met Thr Ser Phe Gly Lys Gly Asn Glu Ala Val Pro Glu His 
            100                 105                 110         


Tyr Ile Phe Glu Asn Gly Met Ile Ser Met Gln Asn Pro Pro Ala Phe 
        115                 120                 125             


Asp Val Glu Asn Arg Gly Thr Ser Phe Ser Ile Ala Gly Lys Asn Ala 
    130                 135                 140                 


Met Asn Ala Ile Ala Asp Asp Pro Arg Arg Thr Ser Lys Lys Val Ile 
145                 150                 155                 160 


Gly Glu Asp Leu Ile Gly Ala Lys Ser Ala Leu Glu Lys Arg Tyr Phe 
                165                 170                 175     


Gly Lys Thr Phe Glu Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
            180                 185                 190         


Leu Asp Ile Glu Lys Ile Leu Ser Lys His Ile Asn Asn Ile Val Phe 
        195                 200                 205             


Ser Ile Asn Asn Ile Arg Gly Ile Ala Asp Pro Glu Arg Asp Asp Leu 
    210                 215                 220                 


Ile Gly Tyr Met Ser Leu Arg Asp Ser Tyr Glu Tyr Phe Met Asp Glu 
225                 230                 235                 240 


Lys Asn Glu Lys Arg Lys Val Leu Arg Glu Ser Tyr Arg Lys Leu Phe 
                245                 250                 255     


Lys Ser Ser Arg Leu Ser Tyr Phe Gly Ser Ala Phe Tyr Val Glu Lys 
            260                 265                 270         


Gln Ser Thr Gln Lys Lys Lys Ser Gly Gln Lys Asn Phe Glu Leu Arg 
        275                 280                 285             


Asn Glu Lys Asp Cys Tyr Tyr Met Leu Ala Leu Leu Gly Glu Leu Arg 
    290                 295                 300                 


Gln Val Leu Ala His Ser Ser Ala Gln Lys Gln Gly Lys Glu Gln Thr 
305                 310                 315                 320 


Glu Ala Arg Ser Ser Val Tyr Asn Leu Arg Thr Val Gly Asn Asn Asp 
                325                 330                 335     


Met Arg Lys Ile Leu Asn Ser Leu Tyr Ala Glu Arg Val Asp Ala Leu 
            340                 345                 350         


Asn Glu Asn Phe Met Asn Tyr Ala Lys Lys Asp Leu Thr Ile Leu Phe 
        355                 360                 365             


Gly Ile Met Asp Ala Ser Ser Tyr Glu Lys Lys Ala Glu Ile Ala Arg 
    370                 375                 380                 


Asp Phe Tyr Asp Phe Thr Val Arg Lys Ser Tyr Lys Asn Ile Gly Phe 
385                 390                 395                 400 


Ser Ile Lys Lys Ile Arg Glu Arg Met Met Asp Cys Phe Phe Ala Asn 
                405                 410                 415     


Val Lys Glu Ile Thr Pro Asp Ser Pro Asp Phe Gln Ser Val Arg Gln 
            420                 425                 430         


Lys Phe Tyr Lys Ile Leu Asp Phe Leu Leu Phe Thr Tyr Tyr Lys Asp 
        435                 440                 445             


Asn Lys Glu Glu Thr Lys Lys Ile Ile Ala Ala Leu Arg Ala Ser Leu 
    450                 455                 460                 


Thr Glu Leu Glu Lys Glu Leu Phe Tyr Gln Lys Gln Ala Asn Ile Leu 
465                 470                 475                 480 


Trp Asn Lys Met Gln Met Val Val Thr Glu Gln Ile Tyr Pro Arg Thr 
                485                 490                 495     


Lys Gly Ser Ala Ile Gln Asn Leu Ile Ala Asp Pro Glu Ile Ser Ala 
            500                 505                 510         


Asp Met Leu Lys Gly Val Met Ile Thr Pro Glu Ser Val Asp Tyr Phe 
        515                 520                 525             


Ser Lys Met Ile Tyr Leu Leu Thr Leu Phe Ile Asp Gly Lys Glu Ile 
    530                 535                 540                 


Asn Asp Leu Leu Thr Thr Met Ile Asn Lys Phe Glu Asn Ile Ala Ser 
545                 550                 555                 560 


Phe Val Ser Val Leu Lys Asp Arg Gly Leu Pro Cys Asn Phe Arg Asn 
                565                 570                 575     


Asp Tyr Ser Val Phe Asn Asn Ala Leu Lys Ile Ser Ala Glu Leu Arg 
            580                 585                 590         


Glu Ile Asn Ser Phe Ala Arg Met Glu Lys Ala Thr Pro Gly Ala Lys 
        595                 600                 605             


Lys Gln Met Phe Leu Asp Ala Ala Ile Ile Leu Gly Ser Asn Glu Ser 
    610                 615                 620                 


Ala Glu Glu Leu Ser Glu Tyr Phe Asp Glu Met Leu Asp Lys Gln Lys 
625                 630                 635                 640 


Gly Lys Arg Thr Pro Gly Gly Lys Lys Asp Met Gly Phe Arg Asn Phe 
                645                 650                 655     


Leu Ile Lys Asn Val Ile Glu Ser Asp Arg Phe His Tyr Leu Ile Arg 
            660                 665                 670         


Tyr Gly His Pro Leu His Ile Arg Lys Leu Ala Glu Asn Lys Asn Val 
        675                 680                 685             


Ile Ala Phe Val Leu Lys Gln Ile Pro Glu Pro Gln Ile Asp Arg Tyr 
    690                 695                 700                 


Cys Lys Ile Cys Ala Leu Pro Ala Glu Ser Asn Phe Ala Gln Lys Ile 
705                 710                 715                 720 


Leu Arg Leu Thr Asp Leu Ile Ala Glu Met Asn Phe Arg Gln Phe Glu 
                725                 730                 735     


Asn Val Arg Gln Thr Glu Lys Asn Glu Gln Lys Gln Ile Leu Gln Gly 
            740                 745                 750         


Ile Leu Ser Leu Tyr Leu Thr Val Leu Tyr Leu Leu Thr Lys Asn Leu 
        755                 760                 765             


Val Tyr Val Asn Ser Arg Tyr Phe Leu Ala Phe His Cys Leu Glu Arg 
    770                 775                 780                 


Asp Thr Glu Leu Leu Gly Ser Gln Ala Gly His Lys Asn Ala Glu Lys 
785                 790                 795                 800 


Gln Leu Ile Ala Ser Tyr Ser Ala Leu Thr Gln Gln Phe Leu Asp Glu 
                805                 810                 815     


Gly Lys Leu Asn Arg His Ala Arg Glu Tyr Leu Thr Val Asn Ile Gln 
            820                 825                 830         


Asn Ser Asp Asp Trp Thr Ile Ala Gln Tyr Arg Asn Asn Ala Ala His 
        835                 840                 845             


Leu Asn Ala Ile Arg Asn Ala His Leu Tyr Ile Arg Glu Met Lys Ser 
    850                 855                 860                 


Val Arg Ser Tyr Phe Glu Leu Tyr His Tyr Leu Thr Gln Arg Ala Leu 
865                 870                 875                 880 


Leu Asp Lys Tyr Glu Asn Val Pro Tyr His Pro Gln Val Asn Glu Lys 
                885                 890                 895     


Thr Leu Lys Tyr Phe Glu Leu Leu Lys Glu Asn Gly Trp Tyr Cys Lys 
            900                 905                 910         


Asp Phe Val Lys Ala Leu Asn Val Pro Phe Gly Tyr Asn Leu Pro Arg 
        915                 920                 925             


Tyr Lys Asn Leu Ser Ile Asp Ala Leu Phe Asp Lys Asp Arg Pro Gln 
    930                 935                 940                 


Glu Glu Asp Glu Asn His Leu Tyr Thr Cys Gln Asn Ile Lys Lys Ser 
945                 950                 955                 960 


<210>  2815
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2815

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Phe 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Ala Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Val Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Lys Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2816
<211>  957
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2816

Met Ile Leu Ile Leu Gly Glu Gly Thr Ile Arg Met Ala Lys Lys Lys 
1               5                   10                  15      


Asn Ala Arg Gln Arg Arg Glu Glu Glu Lys Asn Arg Ile Lys Ala Ile 
            20                  25                  30          


Ile Glu Lys Ile Lys Asn Lys Val Val Glu Lys Glu Glu Thr Glu Glu 
        35                  40                  45              


Ile Val Glu Asn Asn Glu Thr Lys Asn Val Glu Ser Ile Val Val Glu 
    50                  55                  60                  


Pro Lys Lys Lys Ser Leu Ala Lys Ala Ser Gly Val Lys Ser Val Phe 
65                  70                  75                  80  


Ile Asn Asn Asp Glu Ile Ile Met Thr Ser Phe Gly Arg Gly Asn Asp 
                85                  90                  95      


Ala Val Ile Glu Lys Ile Ile Lys Asp Asn Asn Ile Asp Asn Glu Asn 
            100                 105                 110         


Lys Asp Lys Pro Val Tyr Asp Val Val Ala Ile Glu Asn Glu Gly Asn 
        115                 120                 125             


Ile Ile Lys Val Gln Ser Glu Arg Phe Lys Ala Ile Glu Ser Ala Asn 
    130                 135                 140                 


Thr Glu Ile Pro Pro Glu Arg Asn Gly Met Asp Leu Ile Lys Arg Lys 
145                 150                 155                 160 


Asp Lys Leu Glu Glu Val Tyr Phe Gly His Thr Phe Asn Asp Asn Ile 
                165                 170                 175     


His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ser 
            180                 185                 190         


Val Tyr Ile Asn Asn Ile Val Tyr Ala Leu Gly Asn Leu Glu Arg Lys 
        195                 200                 205             


Asp Thr Asp Glu Glu Lys Asp Leu Ile Gly Tyr Ser Ser Ala Arg Ala 
    210                 215                 220                 


Lys Tyr Glu Asp Phe Ile Glu Asn Glu Lys Leu Glu Asp Arg Lys Lys 
225                 230                 235                 240 


Leu Leu Glu Glu Phe Ile Glu Asn Gly Asp Arg Leu Gly Tyr Phe Gly 
                245                 250                 255     


Asn Val Phe Phe Lys Asn Asp Lys Glu Leu Lys Ser Lys Lys Glu Ile 
            260                 265                 270         


Tyr Asn Ile Leu Gly Leu Leu Gly Ser Leu Arg Gln Phe Cys Phe His 
        275                 280                 285             


Tyr Asn Glu Ala Val Phe Glu Asn Glu Glu Gly Lys Ile Asn Gln Glu 
    290                 295                 300                 


Tyr Lys Ser Asn Ser Trp Leu Tyr Asn Leu Gly Gln Leu Phe Asp Glu 
305                 310                 315                 320 


Phe Lys Asp Thr Leu Asn Gly Phe Tyr Asn Glu Lys Ile Asp Ser Ile 
                325                 330                 335     


Asn Lys Asp Phe Ile Lys Thr Asn Gln Ile Asn Leu His Ile Ile Cys 
            340                 345                 350         


Ser Glu Leu Gly Met Asn Met Asp Lys Glu Gln Val Val Gly Asp Tyr 
        355                 360                 365             


Tyr Asp Phe Ile Ile Ser Lys Lys His Lys Asn Met Gly Phe Ser Ile 
    370                 375                 380                 


Lys Lys Ile Arg Glu Tyr Met Phe Asp Ile Tyr Glu Ala Phe Asp Ile 
385                 390                 395                 400 


Lys Asp Lys Glu Phe Asp Ser Val Arg Ser Ile Leu Tyr Lys Ile Ile 
                405                 410                 415     


Asp Phe Ile Ile Tyr Tyr Ser Phe Ile His Tyr Lys Asn Asp Ile Ala 
            420                 425                 430         


Glu Asn Ile Val Ser Arg Leu Arg Val Ser Leu Ser Glu Glu Asp Lys 
        435                 440                 445             


Asp Lys Val Tyr Glu Glu Ile Ala Arg Asp Thr Trp Asn Glu Tyr Lys 
    450                 455                 460                 


Asp Gln Ile Asn Lys Leu Lys Glu Leu Leu Thr Lys Arg Ile Gly Glu 
465                 470                 475                 480 


Phe Ser Asp Ala Lys Asn Lys Asn Val Tyr Tyr Lys Glu Phe Glu Ser 
                485                 490                 495     


Ile Lys Phe Asp Glu Ile Gly Lys Lys Lys Leu Gly Glu Asn Ala Asp 
            500                 505                 510         


Tyr Phe Cys Lys Leu Met Tyr Leu Leu Thr Leu Phe Leu Asp Gly Lys 
        515                 520                 525             


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp Asn Ile 
    530                 535                 540                 


Arg Ser Phe Ile Glu Ile Met Glu Glu Lys Gln Ile Glu Cys Asn Phe 
545                 550                 555                 560 


Asp Glu Lys Phe Ser Phe Phe Asp Glu Ser Lys Asn Val Cys Asp Thr 
                565                 570                 575     


Leu Arg Glu Val Asn Ser Phe Ala Arg Met Gln Arg Pro Leu Asp Asn 
            580                 585                 590         


Lys Ser Val Gln Arg Glu Met Tyr Arg Asp Ala Ile Lys Ile Leu Leu 
        595                 600                 605             


Lys Asp Thr Trp Val Glu Glu Lys Asn Ile Asp Arg Ile Leu Asp Glu 
    610                 615                 620                 


Tyr Ile Pro Asn Lys Glu Asn Lys Ser Ile Lys Lys Asp Phe Arg Asn 
625                 630                 635                 640 


Phe Ile Ile Lys Asn Ile Ile Lys Ser Asn Arg Phe Ile Tyr Leu Ile 
                645                 650                 655     


Lys Tyr Ser Asn Pro Thr Asp Val Arg Lys Leu Ala Ser Asn Lys Asp 
            660                 665                 670         


Val Val Lys Phe Val Leu Asn Thr Ile Pro Glu Ala Gln Ile Asp Arg 
        675                 680                 685             


Tyr Tyr Asn Ser Cys Gly Leu Pro Leu Glu Glu Asp Asn Asn Val Gln 
    690                 695                 700                 


Ile Glu Lys Leu Ser Glu Ile Ile Thr Asn Ile Asp Tyr Ile Glu Phe 
705                 710                 715                 720 


Leu Asp Val Gln Gln Ser Tyr Lys Asn Glu Asp Lys Ser Gln Lys Gln 
                725                 730                 735     


Ala Val Val Thr Leu Tyr Leu Thr Ile Leu Tyr Ile Leu Thr Lys Asn 
            740                 745                 750         


Leu Val Asn Val Asn Ser Arg Tyr Val Ile Ala Leu His Cys Leu Glu 
        755                 760                 765             


Arg Asp Ser Thr Leu Tyr Gly Ile Lys Leu Lys Lys Glu Lys Asn Lys 
    770                 775                 780                 


Pro Ser Lys Tyr His Lys Leu Thr Gln Tyr Phe Ile Asp Asn Arg Tyr 
785                 790                 795                 800 


Phe Asp Arg Lys Lys Lys Asp Arg Lys Asn Gly Glu Tyr Val Ser Lys 
                805                 810                 815     


Lys Ile Ser Gly Tyr Ile Glu Lys Asn Met Lys Asn Tyr Ile Glu Cys 
            820                 825                 830         


Glu Gln Ile Glu Thr Thr Glu Gln Tyr Lys Glu Thr Gly Val Asp Met 
        835                 840                 845             


Phe Ile Asn Tyr Arg Asn Ser Ile Ala His Leu Asn Thr Val Arg Lys 
    850                 855                 860                 


Ala Ser Lys Tyr Ile Lys Asp Ile Lys Tyr Phe Gly Thr Tyr Phe Glu 
865                 870                 875                 880 


Leu Tyr His Tyr Ile Met Gln Arg Tyr Leu Lys Asp Asn Ile Glu Leu 
                885                 890                 895     


Lys Gly Glu Asn Asn Ala Leu Glu Gly Tyr Phe Asp Asn Leu Cys Lys 
            900                 905                 910         


Tyr Gly Thr Tyr Val Lys Asp Phe Val Lys Thr Leu Asn Val Pro Phe 
        915                 920                 925             


Ala Tyr Asn Tyr Pro Arg Tyr Lys Asn Leu Ser Ile Asp Glu Leu Phe 
    930                 935                 940                 


Asp Lys Asn Asn Thr Arg Lys Thr Lys Lys Ser Ser Leu 
945                 950                 955         


<210>  2817
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2817

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Asp Glu Ser His Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn 
    210                 215                 220                 


Pro Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu Tyr Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Ile Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Glu 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asn Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Lys Lys Gln Glu Glu Lys Ile Lys Phe Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2818
<211>  939
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2818

Met Ala Lys Lys Lys Arg Ile Thr Ala Lys Glu Arg Lys Gln Asn His 
1               5                   10                  15      


Arg Glu Ser Leu Met Lys Lys Ala Asp Ser Asn Ala Glu Lys Glu Lys 
            20                  25                  30          


Ala Lys Lys Pro Val Val Glu Asn Lys Pro Asp Thr Ala Ile Ser Lys 
        35                  40                  45              


Asp Asn Ile Pro Lys Pro Asn Lys Glu Ile Lys Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Ala Gly Val Lys Trp Val Ile Lys Ala Asn Asp Asp Val Ala Tyr 
65                  70                  75                  80  


Ile Ser Ser Phe Gly Lys Gly Asn Asn Ser Val Leu Glu Lys Arg Ile 
                85                  90                  95      


Met Gly Asp Val Ser Ser Asn Val Asn Lys Asp Ser His Met Tyr Val 
            100                 105                 110         


Asn Pro Lys Tyr Thr Lys Lys Asn Tyr Glu Ile Lys Asn Gly Phe Ser 
        115                 120                 125             


Ser Gly Ser Ser Leu Val Thr Tyr Pro Asn Lys Pro Asp Lys Asn Ser 
    130                 135                 140                 


Gly Met Asp Ala Leu Cys Leu Lys Pro Tyr Phe Glu Lys Asp Phe Phe 
145                 150                 155                 160 


Gly His Ile Phe Thr Asp Asn Met His Ile Gln Ala Ile Tyr Asn Ile 
                165                 170                 175     


Phe Asp Ile Glu Lys Ile Leu Ala Lys His Ile Thr Asn Ile Ile Tyr 
            180                 185                 190         


Thr Val Asn Ser Phe Asp Arg Asn Tyr Asn Gln Ser Gly Asn Asp Thr 
        195                 200                 205             


Ile Gly Phe Asp Ile Asn Tyr Arg Val Pro Tyr Ser Glu Tyr Gly Gly 
    210                 215                 220                 


Gly Lys Asp Ser Asn Gly Glu Pro Lys Asn Lys Ser Lys Trp Glu Lys 
225                 230                 235                 240 


Arg Lys Asn Phe Ile Lys Phe Tyr Asn Lys Ser Lys Pro His Leu Gly 
                245                 250                 255     


Tyr Tyr Glu Asn Ile Phe Tyr Asp His Gly Glu Pro Ile Ser Glu Glu 
            260                 265                 270         


Lys Phe Tyr Asn Tyr Leu Asn Ile Leu Asn Phe Ile Arg Asn Asn Thr 
        275                 280                 285             


Phe His Tyr Lys Asn Asp Asp Ile Glu Leu Tyr Ser Glu Asn Tyr Ser 
    290                 295                 300                 


Glu Glu Phe Val Phe Ile Asn Cys Leu Asn Lys Phe Val Lys Asn Lys 
305                 310                 315                 320 


Phe Lys Asn Val Asn Lys Asn Phe Ile Ser Asn Glu Lys Asn Asn Leu 
                325                 330                 335     


Tyr Ile Ile Leu Asn Ala Tyr Gly Lys Asp Thr Glu Asn Val Glu Val 
            340                 345                 350         


Val Lys Lys Tyr Ser Lys Glu Leu Tyr Lys Leu Ser Val Leu Lys Thr 
        355                 360                 365             


Asn Lys Asn Leu Gly Val Asn Val Lys Lys Leu Arg Glu Ser Ala Ile 
    370                 375                 380                 


Glu Tyr Gly Tyr Cys Pro Leu Pro Tyr Asp Lys Glu Lys Glu Val Ala 
385                 390                 395                 400 


Lys Leu Ser Ser Ile Lys His Lys Leu Tyr Lys Thr Tyr Asp Phe Val 
                405                 410                 415     


Ile Thr His Tyr Leu Asn Ser Asn Asp Lys Leu Leu Leu Glu Ile Val 
            420                 425                 430         


Glu Ala Leu Arg Leu Ser Lys Asn Asp Asp Glu Lys Glu Asn Val Tyr 
        435                 440                 445             


Lys Lys Tyr Ala Glu Lys Leu Phe Lys Ala Asp Asp Val Ile Asn Pro 
    450                 455                 460                 


Ile Lys Ala Ile Ser Lys Leu Phe Ala Glu Lys Gly Asn Lys Leu Phe 
465                 470                 475                 480 


Lys Glu Met Val Ile Ile Lys Lys Glu Tyr Val Glu Asp Ile Ser Ile 
                485                 490                 495     


Asp Lys Asn Ile Tyr Asp Phe Thr Lys Val Ile Phe Phe Met Thr Cys 
            500                 505                 510         


Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Asn Ile Ile Ser 
        515                 520                 525             


Lys Leu Gln Val Ile Glu Asp His Asn Asn Val Ile Lys Phe Ile Ser 
    530                 535                 540                 


Asn Asn Lys Asp Ala Val Tyr Lys Asp Tyr Ser Asp Lys Tyr Ala Ile 
545                 550                 555                 560 


Phe Arg Asn Ala Gly Lys Ile Ala Thr Glu Leu Glu Ala Ile Lys Ser 
                565                 570                 575     


Ile Val Arg Met Glu Asn Lys Ile Glu Asn Ala Pro Gln Glu Pro Leu 
            580                 585                 590         


Leu Lys Asp Ala Leu Leu Ser Leu Gly Val Ser Asp Asp Thr Lys Val 
        595                 600                 605             


Leu Glu Asn Thr Tyr Lys Lys Tyr Phe Asp Ser Lys Glu Lys Ala Asp 
    610                 615                 620                 


Lys Gln Ser Gln Lys Val Ser Thr Phe Leu Met Asn Asn Val Ile Asn 
625                 630                 635                 640 


Asn Asn Arg Phe Lys Tyr Val Ile Lys Tyr Ile Asn Pro Ala Asp Ile 
                645                 650                 655     


Asn Gly Leu Ala Lys Asn Arg Tyr Leu Val Lys Phe Val Leu Ser Asn 
            660                 665                 670         


Ile Pro Glu Glu Gln Ile Asp Ser Tyr Tyr Lys Leu Phe Ser Asn Glu 
        675                 680                 685             


Glu Glu Pro Ser Cys Glu Glu Lys Ile Lys Leu Leu Thr Lys Lys Ile 
    690                 695                 700                 


Ser Lys Leu Asn Phe Gln Thr Leu Phe Glu Asn Asn Lys Ile Pro Asn 
705                 710                 715                 720 


Val Glu Lys Glu Arg Lys Lys Ala Ile Ile Thr Leu Tyr Phe Thr Ile 
                725                 730                 735     


Val Tyr Ile Leu Val Lys Asn Leu Val Asn Ile Asn Gly Leu Tyr Thr 
            740                 745                 750         


Leu Ala Leu Tyr Phe Val Glu Arg Asp Gly Tyr Phe Tyr Lys Asp Ile 
        755                 760                 765             


Cys Gly Lys Lys Asp Lys Lys Lys Ser Tyr Asn Gly Val Asp Tyr Leu 
    770                 775                 780                 


Leu Leu Pro Glu Ile Phe Ser Gly Ser Lys Tyr Arg Glu Gln Thr Lys 
785                 790                 795                 800 


Asn Leu Lys Leu Pro Lys Glu Lys Asp Arg Asp Ile Met Lys Lys Tyr 
                805                 810                 815     


Leu Pro Asn Asp Lys Asp Arg Glu Gly Tyr Asn Lys Phe Phe Arg Ala 
            820                 825                 830         


Tyr Arg Asn Asn Ile Val His Leu Asn Ile Ile Ala Lys Leu Ser Glu 
        835                 840                 845             


Leu Thr Ser Asn Ile Asp Lys Asp Ile Asn Ser Tyr Phe Asp Ile Tyr 
    850                 855                 860                 


His Tyr Cys Thr Gln Arg Val Met Phe Asn Tyr Cys Lys Glu Asn Asn 
865                 870                 875                 880 


Asn Ile Val Leu Ala Lys Met Lys Asp Leu Ala His Ile Lys Ser Asp 
                885                 890                 895     


Cys Asp Glu Phe Ser Ser Lys His Thr Tyr Pro Phe Ser Ser Ala Val 
            900                 905                 910         


Leu Arg Phe Met Asn Leu Pro Phe Ala Tyr Asn Val Pro Arg Phe Lys 
        915                 920                 925             


Asn Leu Ser Tyr Lys Lys Phe Phe Asp Lys Gln 
    930                 935                 


<210>  2819
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2819

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Lys 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Asp Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Ile Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Ala Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Ala 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2820
<211>  1666
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (50)..(620)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1215)..(1663)
<223>  Xaa can be any naturally occurring amino acid

<400>  2820

Leu Ser Thr Ser Lys Arg Gly Ile Phe Gln Gly Phe Ala Arg Leu Val 
1               5                   10                  15      


Pro His Lys Thr Thr Asp Lys Ile Val Leu Phe Phe Val Thr Gly Ile 
            20                  25                  30          


Ser Ala Phe Arg Leu Arg Leu Ser Val Ser Ile Cys Ser Ser Gln Arg 
        35                  40                  45              


Glu Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    50                  55                  60                  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
65                  70                  75                  80  


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            100                 105                 110         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        115                 120                 125             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    130                 135                 140                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
145                 150                 155                 160 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                165                 170                 175     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            180                 185                 190         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        195                 200                 205             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    210                 215                 220                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
225                 230                 235                 240 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                245                 250                 255     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            260                 265                 270         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        275                 280                 285             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    290                 295                 300                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
305                 310                 315                 320 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                325                 330                 335     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            340                 345                 350         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        355                 360                 365             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    370                 375                 380                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
385                 390                 395                 400 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                405                 410                 415     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            420                 425                 430         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        435                 440                 445             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    450                 455                 460                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
465                 470                 475                 480 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                485                 490                 495     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            500                 505                 510         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        515                 520                 525             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
    530                 535                 540                 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
545                 550                 555                 560 


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                565                 570                 575     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            580                 585                 590         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
        595                 600                 605             


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Leu Gly Leu Lys 
    610                 615                 620                 


Asn Ala Leu Glu Glu Arg Phe Phe Gly Arg Thr Phe Asp Asp Thr Ile 
625                 630                 635                 640 


His Ile Gln Ile Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala 
                645                 650                 655     


Val Tyr Ala Thr Asn Ile Ser Ala Ala Leu Asn His Met Thr Asp Glu 
            660                 665                 670         


Glu Pro Asp Lys Asp Phe Ile Gly Tyr Met Gly Thr Ile Asn Thr Tyr 
        675                 680                 685             


Asp Val Phe Leu Asn Pro Ser Ile Asn Pro Ser Leu Asp Thr Lys Lys 
    690                 695                 700                 


Ile Asn Asn Ile Asp Ser Asn Arg Ala Leu Phe Glu Ser Leu Leu Arg 
705                 710                 715                 720 


Asn Arg Arg Leu Gly Tyr Phe Gly Phe Thr Tyr Asp Pro Asn Leu Thr 
                725                 730                 735     


Ala Asp Lys Lys Leu Pro Glu Asn Glu Lys Asp Arg Lys Lys Ile Gln 
            740                 745                 750         


Lys Gln Ile Gln Lys Asn Glu Glu Glu Lys Lys Arg Ile Tyr His Leu 
        755                 760                 765             


Leu Ala Leu Ala Gly Gln Leu Arg Gln Trp Ser Phe His Gly Asn Ser 
    770                 775                 780                 


Glu Gly Ile Arg Asn Pro Leu Trp Leu Tyr Gln Leu Glu Thr Ser Thr 
785                 790                 795                 800 


Asp Arg Glu Phe Leu Leu Thr Leu Asp His Tyr Phe Asp Asp Arg Phe 
                805                 810                 815     


Asn Asp Ile Asn Lys Asp Phe Ile Lys Gln Asn Glu Val Asn Leu Ala 
            820                 825                 830         


Lys Leu Glu Ile Val Tyr Gly Lys Lys Asn Phe Glu Lys Val Ala Lys 
        835                 840                 845             


Arg Tyr Tyr Asp Phe Ile Val Tyr Lys His Tyr Lys Asn Met Gly Phe 
    850                 855                 860                 


Ser Ile Lys Lys Leu Arg Glu Thr Met Phe Thr Phe Asp Gly Gly Glu 
865                 870                 875                 880 


Gln Ile Thr Ser Pro Arg Met Asp Ser Val Arg Asp Lys Leu Tyr Lys 
                885                 890                 895     


Leu Met Asp Phe Cys Leu Tyr Trp Phe Tyr Met Glu Asn Pro Glu Lys 
            900                 905                 910         


Ile Asp Glu Asn Val Asn Ile Leu Arg Ala Ala Val Ser Glu Glu Glu 
        915                 920                 925             


Lys Glu Lys Phe Tyr Thr Glu Glu Ala Gly Arg Leu Trp Glu Lys Phe 
    930                 935                 940                 


Arg Arg Arg Phe Leu Asp Phe Cys Asp His Ser Arg Asp Lys Asp Phe 
945                 950                 955                 960 


Leu Lys Pro Lys Val Asn Ile Asn Gln Trp Glu Ser Arg Val Asp Val 
                965                 970                 975     


Ser Lys Leu Ser Leu Gln Gly Asp Val Ser Tyr Phe Ala Lys Leu Leu 
            980                 985                 990         


Tyr Ala Ile Cys Phe Phe Leu Asp  Gly Lys Glu Ile Asn  Asp Leu Leu 
        995                 1000                 1005             


Thr Thr  Leu Ile Asn Lys Phe  Asp Asn Ile Arg Ser  Phe Ile Ala 
    1010                 1015                 1020             


Thr Gly  Lys Thr Leu Gly Leu  Asp Val Ser Phe Gln  Ser Glu Tyr 
    1025                 1030                 1035             


Asp Phe  Phe Asn Gln Asp Cys  Ala Arg Tyr Val Ala  Glu Leu Asn 
    1040                 1045                 1050             


Leu Val  Lys Asn Ile Ala Arg  Met Lys Lys Pro Asp  Leu Ser Ala 
    1055                 1060                 1065             


Lys Gln  Thr Met Tyr Arg Asp  Ala Leu His Ile Leu  Gly Val Ser 
    1070                 1075                 1080             


Lys Asp  Met Thr Asp Glu Ala  Phe Glu Glu Glu Leu  Asn Thr Met 
    1085                 1090                 1095             


Leu Asp  Thr Asp Asp Gly Asp  Thr Asn Phe Arg Asn  Phe Ile Cys 
    1100                 1105                 1110             


Asn Asn  Val Ile Lys Ser Asn  Arg Phe Ile Tyr Val  Ile Lys Phe 
    1115                 1120                 1125             


Cys Lys  Ala Glu Thr Val His  Lys Phe Ala Glu Asn  Thr Val Leu 
    1130                 1135                 1140             


Thr Glu  Phe Val Leu Arg Arg  Met Pro Glu Thr Gln  Ile Asn Arg 
    1145                 1150                 1155             


Tyr Tyr  Gln Ser Cys Phe Gly  Ile Lys Asn Pro Val  Asp Tyr Ser 
    1160                 1165                 1170             


Leu Asp  Arg Lys Val Glu Asp  Leu Ala Asp Met Met  Lys Glu Leu 
    1175                 1180                 1185             


His Phe  Asp Asp Phe Lys Asp  Val Lys Gln Lys Thr  Glu Thr Arg 
    1190                 1195                 1200             


Glu Glu  Arg Met Arg Lys Glu  Arg Tyr Lys Ala Xaa  Xaa Xaa Xaa 
    1205                 1210                 1215             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1220                 1225                 1230             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1235                 1240                 1245             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1250                 1255                 1260             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1265                 1270                 1275             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1280                 1285                 1290             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1295                 1300                 1305             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1310                 1315                 1320             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1325                 1330                 1335             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1340                 1345                 1350             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1355                 1360                 1365             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1370                 1375                 1380             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1385                 1390                 1395             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1400                 1405                 1410             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1415                 1420                 1425             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1430                 1435                 1440             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1445                 1450                 1455             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1460                 1465                 1470             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1475                 1480                 1485             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1490                 1495                 1500             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1505                 1510                 1515             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1520                 1525                 1530             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1535                 1540                 1545             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1550                 1555                 1560             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1565                 1570                 1575             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1580                 1585                 1590             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1595                 1600                 1605             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1610                 1615                 1620             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1625                 1630                 1635             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa 
    1640                 1645                 1650             


Xaa Xaa  Xaa Xaa Xaa Xaa Xaa  Xaa Xaa Xaa Ser Ser  Ile 
    1655                 1660                 1665     


<210>  2821
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2821

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Thr Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Lys Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asn Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Gln Asn Thr Tyr Tyr Ile Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu Tyr Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Val Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Val Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Val Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Glu Arg Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ile Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2822
<211>  918
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2822

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Gly Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Asn Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Glu 
    370                 375                 380                 


Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Ile Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Leu Tyr Ala Asp Glu Ala Ala Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Lys Val Ala Glu Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu Arg 
785                 790                 795                 800 


Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr Arg 
                805                 810                 815     


Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu Lys 
            820                 825                 830         


Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile Tyr 
        835                 840                 845             


His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr Lys 
    850                 855                 860                 


Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His Gly 
865                 870                 875                 880 


Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr Asn 
                885                 890                 895     


Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg Asn 
            900                 905                 910         


Glu Tyr Leu Thr Glu Lys 
        915             


<210>  2823
<211>  946
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2823

Met Lys Lys Phe Ser Asn Ile Lys Arg Leu Gly Val Lys Ser Val His 
1               5                   10                  15      


Tyr Ala Asn Asn Thr Val Ile Val Glu Asp His Phe Ser Lys Asn Thr 
            20                  25                  30          


Asn Ile Leu Phe Thr Ala Glu Tyr Glu Asn Ile Asp Asp Leu Lys Ser 
        35                  40                  45              


Cys Thr Asn Ile Asp Lys Thr Ala Glu Asn Lys Gly Val Arg Phe Thr 
    50                  55                  60                  


Asp Leu Lys Asn Lys Asn Gly Phe Glu Leu Ser Ala Met Ala Gln Lys 
65                  70                  75                  80  


Gln Ile Leu Lys Ser Arg Val Asn Arg Val Lys Lys Val Ser Tyr Thr 
                85                  90                  95      


Gln Glu Leu Phe Asp Ile Thr Thr Asp Asn Asn Ile Glu Val Gln Ile 
            100                 105                 110         


Phe Ser Asn Leu Glu Asp Val Lys Lys Val Ile Ala Pro Tyr Tyr Asn 
        115                 120                 125             


Asn Val Ala Tyr Ala Ile Asn Ser Leu Tyr Arg Asp Ile Ser Asn Asp 
    130                 135                 140                 


Asp Ser Tyr Gly Phe Asp Lys Ile Gly Ser Ile Pro Val Asp Ala Asp 
145                 150                 155                 160 


Trp Tyr Asn Phe Leu Lys Asp Ala Pro Asp Lys Lys Glu Lys Trp Thr 
                165                 170                 175     


Thr Tyr Ile Ile Pro Ser Tyr Lys Lys Val Ile Ala Arg Phe Gly Ile 
            180                 185                 190         


Gln Met Glu Lys Asn Gln Gln Val Asn Phe Cys Lys Cys Leu Glu Tyr 
        195                 200                 205             


Val Ala Ile Arg Asn Gly Leu Phe Val Lys Phe Lys Asp Glu Lys Val 
    210                 215                 220                 


Asp Pro Asp Lys Leu Leu Asn Lys Lys Ile Gln Glu Lys Leu Asp Lys 
225                 230                 235                 240 


Leu Ile Ser Asp Lys Glu Val Asn Asp Lys Leu Phe Glu Leu Ala Lys 
                245                 250                 255     


Thr Pro Val Ser Glu Phe Cys Ala Glu Ala Asn Ala Ile Pro Leu Tyr 
            260                 265                 270         


Arg Tyr Ala Phe Ile Gly Gln Lys Gly Lys Arg Ile Glu Lys Ile Val 
        275                 280                 285             


Leu Asp Lys Leu Glu Glu Asn Glu Ile Leu Ser Ser Leu Val Arg Lys 
    290                 295                 300                 


Ile Asp Glu Asn Glu Thr Thr Tyr Asn Tyr Leu Arg Leu Leu Ser Ala 
305                 310                 315                 320 


Ile Arg Gln Tyr Val Val His Asn Ser Arg Lys Val Arg Ile Asp Lys 
                325                 330                 335     


Asn Val Phe Ile Asn Asp Thr Ala Lys Arg Asp Val Glu Glu Phe Ala 
            340                 345                 350         


Lys Gln Phe Gln Lys Asn Asn Tyr Lys Tyr Phe Cys Ile Leu Lys Glu 
        355                 360                 365             


Leu Tyr Ser Asp Ser Asp Ile Leu Glu Gln Phe Phe Asp Tyr Thr Val 
    370                 375                 380                 


Phe Asp Glu Ala Arg Asn Leu Lys Ile Ser Ile Asp Lys Ile Lys Lys 
385                 390                 395                 400 


Gly Ile Thr Ala Asn Ile Asp Ile Ser Ala Asp Val Glu Pro Asp Lys 
                405                 410                 415     


Leu Ser Glu Tyr Ala Asn Lys Phe Arg Thr Val Thr Met Phe Ala Leu 
            420                 425                 430         


Thr Lys Tyr Leu Lys Glu Asn Val Gly Glu Ile Glu Asp Phe Leu Ala 
        435                 440                 445             


Asn Ile Lys Val Cys Ser Ser Asp Glu Glu Lys Ala Gly Val Tyr Glu 
    450                 455                 460                 


Gln Lys Ala Lys Glu Phe Ile Thr Lys Phe Asp Ser Phe Lys Asp Ile 
465                 470                 475                 480 


Arg Ser Val Val Lys Lys His Leu Gly Thr Gln Lys Val Asn Glu Lys 
                485                 490                 495     


Phe Asp Phe Tyr Pro Ser Asp Ile Asn Phe Gly Arg Asp Ser Asn Val 
            500                 505                 510         


Phe Phe Asn Met Leu Tyr Val Met Ser Lys Phe Leu Thr Val Asn Glu 
        515                 520                 525             


Ala Arg Ile Met Phe Gln Lys Ile Lys Ser Lys Tyr Asp Ser Val Lys 
    530                 535                 540                 


Ser Leu Leu Lys Ile Ala Glu Leu Thr Gly Val Thr Leu Ser Asp Asn 
545                 550                 555                 560 


Leu Phe Asp Arg Phe Arg Met Ile Phe Asp Lys Glu Arg Val Asp Glu 
                565                 570                 575     


Tyr Gln Lys Gln Leu Ile Val Leu Gln Ser Ile Arg Thr Arg Asn Gly 
            580                 585                 590         


Val Ser Gln Glu Gly Phe Ala Lys Glu Leu Lys Arg Ile Phe Asp Met 
        595                 600                 605             


Phe Lys Lys Asp Asp Ile Ser Tyr Glu Glu Phe Glu Lys Glu Leu Ser 
    610                 615                 620                 


Leu Asp Glu Asn Gln Asn Glu Ile Lys Asn Lys Ser Phe Lys Leu Lys 
625                 630                 635                 640 


Pro Leu Lys Ser Tyr Leu Arg Asn Asp Val Tyr Lys Ser Lys Gln Tyr 
                645                 650                 655     


Gln Tyr Ile Ser Ser Phe Ala Ser Ala Gly Ile Cys Gln Lys Ile Met 
            660                 665                 670         


Glu Asn Lys Asp Ile Val Ala Phe Val Leu Asn Gly Met Leu Tyr Gln 
        675                 680                 685             


Glu Gly Lys Leu Ser Met Pro Met His Lys Tyr Val Ala Lys Val Tyr 
    690                 695                 700                 


His Asp Phe Arg Arg Glu Lys Ile Asp Glu Asn Ser Ala Asn Tyr Leu 
705                 710                 715                 720 


Leu Asp Gln Asn Gln Ile Ser Ser Leu Val Asn Ser Leu Cys Asp Leu 
                725                 730                 735     


Lys Leu Glu Asn Ile Ile Glu Ala Ile Phe Lys Glu Ser Arg Val Asn 
            740                 745                 750         


Tyr Lys Ala Leu Val Arg Leu Tyr Leu Asn Ile Cys Tyr Leu Phe Val 
        755                 760                 765             


Lys Asn Ile Ile Ser Leu Asn Ser Thr Tyr Leu Ile Gln Phe Gln Asp 
    770                 775                 780                 


Tyr Glu Asn Ile Tyr Lys Gln Leu His Leu Glu Asp Leu Met Asp Ile 
785                 790                 795                 800 


Thr Tyr Asp Phe Gly Val Leu Asn Asn Phe Val Glu Asn Ala Pro Asn 
                805                 810                 815     


Lys Lys Cys Arg Ser Tyr Met Gln Leu Gln Thr Leu Leu Glu Lys Asp 
            820                 825                 830         


Tyr Ile Lys Asp Tyr Ile Tyr Thr Pro Glu Tyr Gln Val Leu Gln Asp 
        835                 840                 845             


Arg Tyr Arg Asn Leu Val Val His Ser Ser Leu Leu Phe Gly Leu Asp 
    850                 855                 860                 


Lys Ile Asp Phe Asp Phe Gly Glu Val Gln Asn Ile Ser Ser Tyr Phe 
865                 870                 875                 880 


Ala Ile Tyr Gln Thr Leu Val Gln Arg Leu Val Glu Gln Asp Ala Arg 
                885                 890                 895     


Glu Val Trp Gly Glu Lys Phe Asp Glu Tyr Phe Ala Leu Asn Asn Gly 
            900                 905                 910         


Lys Thr Tyr Ser Thr Lys Leu Cys Ile Ala Leu Asn Met Pro Tyr Ala 
        915                 920                 925             


Tyr Asn Ile Ser Arg Phe Asn Asn Asn Thr Ile Glu Lys Tyr Ser Asn 
    930                 935                 940                 


Lys Arg 
945     


<210>  2824
<211>  1141
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2824

Met Gly Val Glu Lys Asn Lys Val Phe Glu Ser Val Ile Met Asn Phe 
1               5                   10                  15      


Asp Gln Glu Arg Lys Tyr Gly Phe Ile Glu Tyr Lys Glu Thr Asn Asn 
            20                  25                  30          


Leu Phe Phe His Met Glu Asn Val Lys Asn Pro Lys Glu Ile Val Lys 
        35                  40                  45              


Gly Ala Lys Val Arg Phe Glu Ile Tyr Glu Asn Pro Lys Pro Lys Lys 
    50                  55                  60                  


Gln Asn Gln Arg Phe Ser Ala Ile Asn Val Glu Val Ile Thr Asp Glu 
65                  70                  75                  80  


Thr His Lys Glu Ala Lys Ile Gln Lys Asn Glu Phe Lys Thr Phe Asp 
                85                  90                  95      


Gln Phe Thr Lys Glu Leu Gln Glu Thr Gln Lys Val Asn Gly Glu Thr 
            100                 105                 110         


Lys Lys Glu His Ile Thr Lys Asn Lys His Thr Asn Val Lys Ala Ala 
        115                 120                 125             


Gly Val Lys Ser Val Phe Ala Val Asp Asp Gly Asn Val Leu Ile Thr 
    130                 135                 140                 


Ser Phe Gly Arg Gly Asn Ala Ala Asp Ile Glu Thr Leu Lys Ser Asp 
145                 150                 155                 160 


Asp Asp Lys Thr Ile Asn Leu Thr Glu Thr Glu Asn Gln Lys Lys Tyr 
                165                 170                 175     


Val Val Thr Asn Lys Arg Ser Asn Val Lys Gly Leu Ala Asp Asn Pro 
            180                 185                 190         


Thr Lys Val Glu Ser Ile Ile Pro Gly Glu Thr Gln Ile Gly Phe Lys 
        195                 200                 205             


Ser Ile Leu Glu Lys His Phe Phe Gly Arg Thr Phe Asn Asp Asn Ile 
    210                 215                 220                 


His Ile Gln Ile Ile His Asn Ile Leu Asp Ile Lys Lys Ile Leu Ala 
225                 230                 235                 240 


Val His Thr Asn Asn Ile Val Tyr Ala Leu Asp Asn Ile His Glu Arg 
                245                 250                 255     


Gly Arg Glu Asn Ser Ala Glu Lys Pro Ile Asp Met Ile Gly Ala Gly 
            260                 265                 270         


Gly Ile Ser Thr Ser Lys Glu Tyr Glu Gln Tyr Cys Ser Glu Lys Ser 
        275                 280                 285             


Asp Tyr Glu Asp Asn Phe Leu Lys Gln Leu Ile Asn Asn Glu Arg Ile 
    290                 295                 300                 


Ala Tyr Phe Gly Asn Ala Phe Phe Lys Asp Glu Gly Asn Lys Lys Val 
305                 310                 315                 320 


Met Arg Thr Glu Lys Glu Ile Tyr Tyr Ile Leu Gly Met Leu Asn Glu 
                325                 330                 335     


Val Arg Asn Val Ser Thr His Phe Thr Glu Glu Asp Asn Arg Asp Trp 
            340                 345                 350         


Ala Lys Ala Asn Leu Tyr Asn Leu Ser Asn Arg Leu Lys Val Gly Ser 
        355                 360                 365             


Lys Glu Val Leu Asn Gln Leu Tyr Lys Glu Lys Ile Asp Lys Ile Asp 
    370                 375                 380                 


Ala Asn Gly Phe Val Asn Lys Gly Cys Lys Arg Asp Phe Ser Ile Leu 
385                 390                 395                 400 


Phe Lys Ser Leu Asn Leu Thr Thr Asp Lys Asp Lys Gly Glu Leu Val 
                405                 410                 415     


Val Gly Phe Tyr Asp Phe Ser Ile Arg Lys Asn Tyr Lys Asn Ile Gly 
            420                 425                 430         


Phe Ser Ile Lys Thr Leu Arg Glu Tyr Met Leu Lys Ile Ser Asn Ser 
        435                 440                 445             


Thr Leu Cys Ala Asp Thr Ile Ser Asn Asn Ala Ile Arg Pro Lys Ala 
    450                 455                 460                 


Tyr Lys Leu Tyr Asp Phe Ile Ile Trp His Tyr Tyr Met Asn Lys Pro 
465                 470                 475                 480 


Asp Lys Ile Asn Asp Phe Val Glu Lys Leu Arg Thr Gln Asn Lys Asn 
                485                 490                 495     


Asp Glu Lys Ile Lys Leu Tyr Tyr Asp Glu Ala Val Cys Leu Leu Ser 
            500                 505                 510         


Glu Leu Gly Arg Glu Ile His Thr Met Thr Ser Cys Val His Asn Ile 
        515                 520                 525             


Glu Asn Thr Ser Tyr Glu Ile Thr Asp Lys Lys Gln Lys Glu Tyr Tyr 
    530                 535                 540                 


Lys Met Gln Ile Asn Ser Leu Asn Ser Ala Asp Lys Val Ser Asp Phe 
545                 550                 555                 560 


Ser Lys Val Ile Tyr Leu Val Thr Leu Phe Leu Asp Gly Lys Glu Ile 
                565                 570                 575     


Asn Asp Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp Asn Ile Ala Ser 
            580                 585                 590         


Leu Leu Ser Val Leu Glu Lys Gln Ser Gly Lys Lys Val Glu Phe Val 
        595                 600                 605             


Glu Asn Tyr Ser Phe Phe Asn Ser Ser Asn Leu Leu Lys Glu Lys Thr 
    610                 615                 620                 


Leu Asn Lys Ser Glu Asn Tyr Thr Cys Lys Ile Val Glu Glu Leu Arg 
625                 630                 635                 640 


Glu Ile Asn Ser Phe Ala Arg Met Thr Gly Asp Cys Lys Ile Arg Lys 
                645                 650                 655     


Ser Ala Phe Glu Asp Ala Ser Gln Leu Leu Gly Tyr His Asp Lys Thr 
            660                 665                 670         


Val Asn Asn Leu Phe Glu Val Leu Arg Leu Lys Glu Leu Glu Ser Lys 
        675                 680                 685             


Asp Trp Lys Lys Arg Thr Asp Asp Glu Gln Gln Glu Tyr Asp Arg Leu 
    690                 695                 700                 


Leu Asn Lys His His Tyr Phe Lys Ser Gly Lys Lys Leu Pro Asp Thr 
705                 710                 715                 720 


Gly Leu Arg Asn Phe Ile Ile Asn Asn Val Ile Glu Ser Arg Arg Phe 
                725                 730                 735     


Asn Tyr Ile Val Arg Tyr Ala Asp Pro Lys Lys Ile Arg Lys Cys Thr 
            740                 745                 750         


Glu Asn Asn Glu Leu Leu Lys Phe Ala Phe Lys Asp Val Pro Asp Ser 
        755                 760                 765             


Gln Val Asp Arg Tyr Tyr Asn Ile Cys Val Thr Asn Lys Ile Thr Asn 
    770                 775                 780                 


Ala Thr Arg Glu Glu Lys Ile Glu Arg Leu Val Asp Ile Ile Lys Ser 
785                 790                 795                 800 


Met Asn Leu Ser Lys Val Ala Thr Val Lys Gln Arg Asp Lys Gln Asp 
                805                 810                 815     


Asn Val Glu Lys Gln Lys Gln Leu Ala Ile Met Ser Leu Tyr Leu Asn 
            820                 825                 830         


Ile Leu Tyr Gln Ile Ala Lys Asn Leu Val Tyr Val Asn Ser Arg Tyr 
        835                 840                 845             


Val Met Ala Phe His Ser Leu Glu Arg Asp Ser Gln Met Leu Phe Asp 
    850                 855                 860                 


Ala Tyr Tyr Asp Val Lys Arg Gly Tyr Cys Asp Leu Ser Thr Val Leu 
865                 870                 875                 880 


Leu Phe Gly Val Asp Asp Leu Gln Asn Arg Asn Arg Gly Ser Tyr Lys 
                885                 890                 895     


Tyr Leu Arg Asp Asn Arg Arg Ser Asn Lys Asp Val Ile Glu Thr Phe 
            900                 905                 910         


Gly Asp Phe Lys Gly Lys Val Ser Lys Val Val Glu Lys Lys Asn Gln 
        915                 920                 925             


Gly Leu Thr Asn Glu Ile Tyr Asp Ser Leu Cys Asn Val Ala Gly Thr 
    930                 935                 940                 


Thr Lys Thr Glu Val Gln Asn Glu Ile Lys Ser Ile Leu Lys Ser Asn 
945                 950                 955                 960 


Gly Leu Asp Glu Ser Ala Ser Ser Tyr Leu Ser His Lys Leu Val Asn 
                965                 970                 975     


Lys Val His Ser Tyr Lys Tyr Leu Lys Gln Asn Leu Asp Cys Ala Asp 
            980                 985                 990         


Asn Thr Met Ile Asn Gln Phe Arg  Asn Asn Val Ala His  Leu Asn Thr 
        995                 1000                 1005             


Ile Arg  Asn Met Asp Gly Ile  Glu Asn Val Thr Gly  Ile Thr Ser 
    1010                 1015                 1020             


Tyr Phe  Gln Ile Tyr His Tyr  Leu Met Gln Lys Ala  Leu Tyr Lys 
    1025                 1030                 1035             


Glu Phe  Lys Lys Cys Arg Glu  Asn Ala Val Arg Lys  Trp Ile Pro 
    1040                 1045                 1050             


Tyr Ile  Thr Glu Asn Ala Glu  Pro Lys Tyr Val Tyr  Trp Asn Lys 
    1055                 1060                 1065             


Lys Glu  Gln Gln Glu Val Glu  Val Ser Phe Asn Pro  Lys Ile Phe 
    1070                 1075                 1080             


Gly Tyr  Met Glu Asn Ile Lys  Asn His Ser Asn Thr  Tyr Cys Lys 
    1085                 1090                 1095             


Asp Phe  Val Lys Ala Leu Cys  Ala Pro Phe Ala Tyr  Asn Leu Pro 
    1100                 1105                 1110             


Arg Phe  Lys Asn Leu Ser Ile  Glu Glu Leu Phe Asp  Met His Glu 
    1115                 1120                 1125             


Leu Ser  Glu Glu Pro Lys Glu  Ser Met Lys Leu Thr  Asp 
    1130                 1135                 1140     


<210>  2825
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2825

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Lys Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asn Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Asp Glu Ser His Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe Thr Asp 
    210                 215                 220                 


Pro Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Asn Ala Leu Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Pro Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp Asp Ile 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  2826
<211>  926
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2826

Met Leu Leu Cys Ala Ile Ile Gln Ala Ser Thr Lys Arg Asp Arg Lys 
1               5                   10                  15      


Gly Gly Val Arg Met Glu Arg Glu Val Lys Lys Pro Pro Lys Lys Ser 
            20                  25                  30          


Leu Ala Lys Ala Ala Gly Leu Lys Ser Thr Phe Val Ile Ser Pro Gln 
        35                  40                  45              


Glu Lys Glu Leu Ala Met Thr Ala Phe Gly Arg Gly Asn Asp Ala Leu 
    50                  55                  60                  


Leu Gln Lys Arg Ile Val Asp Gly Val Val Arg Asp Val Ala Gly Glu 
65                  70                  75                  80  


Lys Gln Gln Phe Gln Val Gln Arg Gln Asp Glu Ser Arg Phe Arg Leu 
                85                  90                  95      


Gln Asn Ser Arg Leu Ala Asp Arg Thr Val Thr Ala Asp Asp Pro Leu 
            100                 105                 110         


His Arg Ala Glu Thr Pro Arg Arg Gln Pro Leu Gly Ala Gly Met Asp 
        115                 120                 125             


Gln Leu Arg Arg Lys Ala Met Leu Glu Gln Lys Tyr Phe Gly Arg Thr 
    130                 135                 140                 


Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile 
145                 150                 155                 160 


His Lys Met Leu Ala Val Pro Ala Asn His Ile Val His Thr Leu Asn 
                165                 170                 175     


Leu Leu Gly Gly Tyr Gly Glu Thr Asp Phe Val Gly Met Leu Pro Ala 
            180                 185                 190         


Gly Leu Pro Tyr Asp Lys Leu Arg Val Val Lys Lys Lys Asn Gly Asp 
        195                 200                 205             


Thr Val Asp Ile Lys Ala Asp Ile Ala Ala Tyr Ala Lys Arg Pro Gln 
    210                 215                 220                 


Leu Ala Tyr Leu Gly Ala Ala Phe Tyr Asp Val Thr Pro Gly Lys Ser 
225                 230                 235                 240 


Lys Arg Asp Ala Ala Arg Gly Arg Val Lys Arg Glu Gln Asp Val Tyr 
                245                 250                 255     


Thr Ile Leu Ser Leu Met Ser Leu Leu Arg Gln Phe Cys Ala His Asp 
            260                 265                 270         


Ser Val Arg Ile Trp Gly Gln Asn Thr Pro Ala Ala Leu Tyr His Leu 
        275                 280                 285             


Gln Ala Leu Pro Gln Asp Met Lys Asp Leu Leu Asp Asp Gly Trp Arg 
    290                 295                 300                 


Arg Ala Leu Gly Gly Val Asn Asp His Phe Leu Asp Thr Asn Lys Val 
305                 310                 315                 320 


Asn Leu Leu Thr Leu Phe Glu Tyr Tyr Gly Ala Glu Thr Lys Gln Ala 
                325                 330                 335     


Arg Val Ala Leu Thr Gln Asp Phe Tyr Arg Phe Val Val Leu Lys Glu 
            340                 345                 350         


Gln Lys Asn Met Gly Phe Ser Leu Arg Arg Leu Arg Glu Glu Leu Leu 
        355                 360                 365             


Lys Leu Pro Asp Ala Ala Tyr Leu Thr Gly Gln Glu Tyr Asp Ser Val 
    370                 375                 380                 


Arg Gln Lys Leu Tyr Met Leu Leu Asp Phe Leu Leu Cys Arg Leu Tyr 
385                 390                 395                 400 


Ala Gln Glu Arg Ala Asp Arg Cys Glu Glu Leu Val Ser Ala Leu Arg 
                405                 410                 415     


Cys Ala Leu Ser Asp Glu Glu Lys Gly Ala Val Tyr Gln Ala Glu Ala 
            420                 425                 430         


Ala Ala Leu Trp Gln Ala Leu Gly Asp Thr Leu Arg Arg Glu Leu Leu 
        435                 440                 445             


Pro Leu Leu Lys Gly Lys Lys Leu Gln Asp Lys Asp Lys Lys Lys Leu 
    450                 455                 460                 


Asp Glu Leu Gly Leu Ser Arg Asp Val Leu Asp Gly Val Leu Phe Arg 
465                 470                 475                 480 


Pro Ala Gln Gln Gly Asn Arg Ala Asn Ala Asp Tyr Phe Cys Arg Leu 
                485                 490                 495     


Met His Leu Ser Thr Trp Phe Met Asp Gly Lys Glu Ile Asn Thr Leu 
            500                 505                 510         


Leu Thr Thr Leu Ile Ser Lys Leu Glu Asn Ile Asp Ser Leu Arg Ser 
        515                 520                 525             


Val Leu Glu Ser Met Gly Leu Ala Cys Ser Phe Val Pro Ala Tyr Ala 
    530                 535                 540                 


Met Phe Asp His Ser Arg Tyr Ile Ala Gly Gln Leu Arg Val Val Asn 
545                 550                 555                 560 


Asn Ile Ala Arg Met Arg Lys Pro Ala Ile Thr Ala Lys Arg Glu Met 
                565                 570                 575     


Tyr Arg Ala Ala Val Val Leu Leu Gly Val Asp Ser Pro Glu Ala Ala 
            580                 585                 590         


Ala Ala Ile Thr Asp Asp Leu Leu Gln Ile Asp Pro Glu Thr Gly Lys 
        595                 600                 605             


Val Arg Pro Arg Gly Asp Ser Thr Arg Asp Thr Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Ala Asn Asn Val Val Glu Ser Arg Arg Phe Thr Tyr Leu Leu Arg 
625                 630                 635                 640 


Tyr Met Thr Pro Glu Gln Ala Arg Val Leu Ala Gln Asn Glu Lys Leu 
                645                 650                 655     


Ile Ala Phe Val Leu Ser Thr Val Pro Ser Ala Gln Leu Glu Arg Tyr 
            660                 665                 670         


Cys Arg Thr Cys Gly Trp Glu Asp Ile Thr Asp Arg Pro Ala Gln Ile 
        675                 680                 685             


Arg Tyr Leu Thr Ala Gln Ile Met Gly Val Arg Tyr Glu Ser Phe Thr 
    690                 695                 700                 


Asp Val Glu Gln Arg Gly Arg Gly Asp Asn Pro Lys Lys Glu Arg Tyr 
705                 710                 715                 720 


Lys Ala Leu Ile Gly Leu Tyr Leu Thr Val Leu Tyr Leu Ala Val Lys 
                725                 730                 735     


Asn Met Val Asn Cys Asn Ala Arg Tyr Val Ile Ala Phe Tyr Cys Arg 
            740                 745                 750         


Asp Arg Asp Thr Ala Leu Tyr Gln Lys Glu Val Cys Trp Tyr Asp Leu 
        755                 760                 765             


Glu Glu Asp Lys Lys Ser Gly Lys Gln Arg Gln Val Glu Asp Tyr Thr 
    770                 775                 780                 


Ala Leu Thr Arg Tyr Phe Val Ser Gln Gly Tyr Leu Asn Arg His Ala 
785                 790                 795                 800 


Cys Gly Tyr Leu Arg Ser Asn Met Asn Gly Ile Ser Asn Gly Leu Leu 
                805                 810                 815     


Thr Ala Tyr Arg Asn Ala Val Asp His Leu Asn Ala Ile Pro Pro Leu 
            820                 825                 830         


Gly Gly Leu Cys Arg Asp Ile Gly Arg Val Asp Ser Tyr Phe Ala Leu 
        835                 840                 845             


Tyr His Tyr Ala Val Gln Gln Tyr Leu Asn Gly Arg Tyr Tyr Arg Lys 
    850                 855                 860                 


Thr Pro Arg Glu Gln Glu Leu Phe Ala Ala Met Ala Gln His Arg Thr 
865                 870                 875                 880 


Trp Cys Ser Asp Leu Val Lys Ala Leu Asn Thr Pro Phe Gly Tyr Asn 
                885                 890                 895     


Leu Ala Arg Tyr Lys Asn Leu Ser Ile Asp Gly Leu Phe Asp Arg Glu 
            900                 905                 910         


Gly Asp His Val Val Arg Glu Asp Gly Glu Lys Pro Ala Glu 
        915                 920                 925     


<210>  2827
<211>  984
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2827

Met Lys Lys Lys Asn Ile Arg Ala Thr Arg Glu Ala Leu Lys Ala Gln 
1               5                   10                  15      


Lys Ile Lys Lys Ser Gln Glu Asn Glu Ala Leu Lys Lys Gln Lys Leu 
            20                  25                  30          


Ala Glu Glu Ala Ala Gln Lys Arg Arg Glu Glu Leu Glu Lys Lys Asn 
        35                  40                  45              


Leu Ala Gln Trp Glu Glu Thr Ser Ala Glu Gly Arg Arg Ser Arg Val 
    50                  55                  60                  


Lys Ala Val Gly Val Lys Ser Val Phe Val Val Gly Asp Asp Leu Tyr 
65                  70                  75                  80  


Leu Ala Thr Phe Gly Asn Gly Asn Glu Thr Val Leu Glu Lys Lys Ile 
                85                  90                  95      


Thr Pro Asp Gly Lys Ile Thr Thr Phe Pro Glu Glu Glu Thr Phe Thr 
            100                 105                 110         


Ala Lys Leu Lys Phe Ala Lys Thr Glu Leu Thr Glu Ala Thr Ser Ile 
        115                 120                 125             


Gly Ile Ser Asn Gly Arg Ile Val Leu Pro Glu Ile Ser Val Asp Asn 
    130                 135                 140                 


Pro Leu His Thr Thr Met Gln Lys Asn Thr Ile Lys Lys Ser Ala Gly 
145                 150                 155                 160 


Glu Asp Met Leu Gln Leu Lys Asp Val Leu Glu Asn Arg Tyr Phe Asp 
                165                 170                 175     


Arg Ser Phe Asn Asn Asp Leu His Ile Arg Leu Ile Tyr Asn Ile Leu 
            180                 185                 190         


Asp Ile Glu Lys Ile Leu Ala Glu Tyr Thr Thr Asn Ala Val Phe Ala 
        195                 200                 205             


Ile Asp Asn Val Ser Gly Cys Ser Asp Asp Phe Leu Ser Asn Phe Ser 
    210                 215                 220                 


Thr Arg Asn Gln Trp Asp Glu Phe Gln Asn Pro Glu Gln His Arg Glu 
225                 230                 235                 240 


His Phe Gly Asn Lys Asp Asn Val Ile Cys Ser Val Lys Lys Gln Gln 
                245                 250                 255     


Asp Leu Phe Phe Asn Phe Phe Lys Asn Asn Arg Ile Gly Tyr Phe Gly 
            260                 265                 270         


Lys Ala Phe Phe His Ala Glu Ser Glu Arg Lys Ile Val Lys Lys Thr 
        275                 280                 285             


Ala Lys Glu Val Tyr His Ile Leu Thr Leu Ile Gly Ser Leu Arg Gln 
    290                 295                 300                 


Trp Ile Thr His Ser Thr Glu Gly Gly Ile Ser Arg Leu Trp Leu Tyr 
305                 310                 315                 320 


Gln Leu Glu Asp Ala Leu Ser Ser Glu Tyr Gln Glu Thr Met Asn Asn 
                325                 330                 335     


Cys Tyr Asn Ser Thr Ile Tyr Gly Leu Gln Lys Asp Phe Glu Lys Thr 
            340                 345                 350         


Asn Ala Pro Asn Leu Asn Phe Leu Ala Glu Ile Leu Gly Lys Asn Ala 
        355                 360                 365             


Ser Glu Leu Ala Glu Pro Tyr Phe Arg Phe Ile Ile Thr Lys Glu Tyr 
    370                 375                 380                 


Lys Asn Leu Gly Phe Ser Ile Lys Thr Leu Arg Glu Met Leu Leu Asp 
385                 390                 395                 400 


Gln Pro Asp Leu Gln Glu Ile Arg Glu Asn His Asn Val Tyr Asp Ser 
                405                 410                 415     


Ile Arg Ser Lys Leu Tyr Lys Met Met Asp Phe Val Leu Val Tyr Ala 
            420                 425                 430         


Tyr Ser Asn Glu Arg Lys Ser Lys Ala Asp Ala Leu Ala Ser Asn Leu 
        435                 440                 445             


Arg Ser Ala Ile Thr Glu Asp Ala Lys Lys Arg Val Tyr Gln Asn Glu 
    450                 455                 460                 


Ala Asp Gln Leu Trp Thr Ser Tyr Gln Glu Leu Phe Lys Arg Ile Arg 
465                 470                 475                 480 


Gly Phe Lys Gly Ala Gln Val Lys Glu Tyr Ser Ser Gln Asn Met Pro 
                485                 490                 495     


Ile Pro Ile Gln Lys Gln Ile Gln Asn Ile Leu Lys Pro Ala Glu Gln 
            500                 505                 510         


Val Thr Cys Phe Thr Lys Leu Met Tyr Leu Leu Thr Met Phe Leu Asp 
        515                 520                 525             


Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp 
    530                 535                 540                 


Asn Ile Ser Ser Leu Leu Lys Thr Met Glu Gln Leu Glu Leu Gln Thr 
545                 550                 555                 560 


Thr Phe Lys Glu Asp Tyr Thr Phe Phe Gln Gln Ser Ser Cys Leu Cys 
                565                 570                 575     


Glu Glu Ile Thr Gln Leu Lys Ser Phe Ala Arg Met Gly Asn Pro Ile 
            580                 585                 590         


Ser Asn Leu Lys Glu Val Met Met Val Asp Ala Ile Gln Ile Leu Gly 
        595                 600                 605             


Thr Glu Lys Ser Glu Gln Glu Leu Gln Ser Met Ala Cys Phe Phe Phe 
    610                 615                 620                 


Arg Asp Lys Asn Gly Lys Lys Leu Asn Ala Gly Glu His Gly Met Arg 
625                 630                 635                 640 


Asn Phe Ile Gly Asn Asn Val Ile Ser Asn Thr Arg Phe Gln Tyr Leu 
                645                 650                 655     


Ile Arg Tyr Gly Asn Pro Gln Lys Leu His Thr Leu Ser Gln Asn Glu 
            660                 665                 670         


Thr Val Val Arg Phe Val Leu Ser Arg Ile Ala Lys Asn Gln Arg Val 
        675                 680                 685             


Gln Gly Met Asn Gly Lys Asn Gln Ile Asp Arg Tyr Tyr Glu Thr Cys 
    690                 695                 700                 


Gly Gly Thr Asn Ser Trp Ser Val Ser Glu Glu Glu Lys Ile Asn Phe 
705                 710                 715                 720 


Leu Cys Lys Ile Leu Thr Asn Met Ser Tyr Asp Gln Phe Gln Asp Val 
                725                 730                 735     


Lys Gln Ser Asp Lys Ile Ile Thr Ala Glu Glu Lys Arg Lys Lys Glu 
            740                 745                 750         


Arg Tyr Lys Ala Ile Ile Ser Leu Tyr Leu Thr Val Leu Tyr Gln Leu 
        755                 760                 765             


Ile Lys Asn Leu Val Asn Ile Asn Ala Arg Tyr Ile Ile Ala Phe His 
    770                 775                 780                 


Cys Leu Glu Arg Asp Ala Ile Leu Tyr Ser Leu Lys Phe Asn Thr Ser 
785                 790                 795                 800 


Ile Asn Leu Lys Lys Arg Tyr Thr Ala Leu Thr Glu Met Ile Leu Gly 
                805                 810                 815     


Tyr Glu Thr Asp Glu Lys Ala Arg Arg Lys Asp Thr Arg Thr Ile Tyr 
            820                 825                 830         


Glu Lys Ala Glu Ala Ala Lys Asn Arg His Leu Lys Asn Val Lys Trp 
        835                 840                 845             


Asn Cys Lys Thr Arg Glu Asn Leu Glu Asn Ala Asp Lys Asn Ala Ile 
    850                 855                 860                 


Val Ala Phe Arg Asn Ile Val Ala His Leu Trp Ile Ile Arg Asp Ala 
865                 870                 875                 880 


Asp Arg Phe Ile Thr Glu Met Gly Ala Met Lys Arg Tyr Phe Asp Cys 
                885                 890                 895     


Tyr His Tyr Leu Leu Gln Arg Glu Leu Glu Tyr Ile Leu Glu Lys Ser 
            900                 905                 910         


Asn Gln Gly Ser Lys Tyr Thr Lys Lys Ser Leu Glu Lys Val Gln Gln 
        915                 920                 925             


Tyr His Ser Tyr Cys Lys Asp Phe Leu His Met Leu Cys Leu Pro Phe 
    930                 935                 940                 


Ala Tyr Cys Ile Pro Arg Tyr Lys Asn Leu Ser Ile Ala Glu Leu Phe 
945                 950                 955                 960 


Asp Arg His Glu Leu Glu Ala Glu Pro Lys Glu Glu Ala Ser Pro Ala 
                965                 970                 975     


Asn Asn Ser Gln Phe Ile Thr Thr 
            980                 


<210>  2828
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2828

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Asn Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Met Lys 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Ile Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Asn Arg Val Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2829
<211>  1025
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2829

Met Ala Lys Lys Ile Thr Ala Lys Gln Lys Arg Glu Glu Lys Glu Arg 
1               5                   10                  15      


Leu Asn Lys Gln Lys Trp Ala Lys Gln Asp Thr Pro Val Val Pro Lys 
            20                  25                  30          


Ser Lys Thr Glu Glu Lys Pro Val Ala Ala Ser Asp Asp Lys Leu Leu 
        35                  40                  45              


Lys Thr Thr Gln Val Lys Lys Val Gln Thr Lys Ser Lys Ala Lys Ala 
    50                  55                  60                  


Met Gly Leu Lys Thr Val Leu Ser Phe Asp Asp Lys Ile Ala Ile Ala 
65                  70                  75                  80  


Ser Phe Val Asn Asp Lys Lys Thr Lys Leu Pro His Ile Glu Arg Val 
                85                  90                  95      


Thr Asp Lys Ser Gly Thr Thr Ile His Glu Asn Ala Arg Met Phe Asp 
            100                 105                 110         


Ser Ser Val Asp Glu Gln Asn Val Asn Ile Glu Lys Arg Met Thr Ile 
        115                 120                 125             


Glu Glu Lys Gln Asn Asp Gly Thr Phe Lys Lys Asp Glu Ile Asp Val 
    130                 135                 140                 


Lys Ala Thr Val Cys Asn Pro Tyr Phe Lys Thr Cys Gly Lys Asp Tyr 
145                 150                 155                 160 


Ile Gly Ile Lys Asp Val Ala Glu Lys Tyr Phe Phe Gly Lys Thr Phe 
                165                 170                 175     


Pro Asn Glu Asn Leu Arg Val Gln Ile Ala Tyr Asn Val Phe Asp Ile 
            180                 185                 190         


Gln Lys Ile Leu Gly Thr Tyr Val Asn Asn Ile Ile Tyr Ser Phe Tyr 
        195                 200                 205             


Asn Leu Arg Arg Asp Gly Lys Ser Asp Val Asp Ile Ile Gly Ser Leu 
    210                 215                 220                 


Tyr Ala Phe Ala Asp Phe Asp Asn Gln Leu Lys Asp Lys Pro Ala Phe 
225                 230                 235                 240 


Arg Glu Ala Lys Asp Leu Leu Lys Asn Thr Glu Ala Tyr Phe Ser Tyr 
                245                 250                 255     


Phe Gly Asp Val Phe Lys Lys Ser Lys Lys Gly Lys Lys Asp Glu Asn 
            260                 265                 270         


Asn Glu Asp Tyr Glu Lys Asn Leu Arg His Asn Phe Asn Val Leu Arg 
        275                 280                 285             


Val Leu Ser Phe Leu Arg Gln Ile Cys Thr His Ala Tyr Val Lys Cys 
    290                 295                 300                 


Thr Ser Gly Ala Lys Asn Asn Gly Asp Ser Thr Lys Thr Glu Ser Leu 
305                 310                 315                 320 


Asp Ala Leu Phe Asn Ile Thr Glu Tyr Phe Asp Lys Thr Ala Pro Glu 
                325                 330                 335     


Leu Ser Lys Thr Ile Asn Glu Ile Tyr Lys Glu Gly Val Asp Arg Ile 
            340                 345                 350         


Asn Asn Asp Phe Val Thr Asn Gly Lys Asn Asn Leu Tyr Ile Leu Ser 
        355                 360                 365             


Lys Val Tyr Pro Asp Met Gln Arg Asn Glu Leu Val Lys Lys Tyr Tyr 
    370                 375                 380                 


Gln Phe Val Val Cys Lys Glu Gly Asn Asn Val Gly Ile Asn Thr Arg 
385                 390                 395                 400 


Lys Leu Lys Glu Ser Ile Ile Ser Gln Asn Pro Trp Ile Thr Thr Pro 
                405                 410                 415     


Gln Asp Asn Asn Lys Ala Asn Asp Tyr Glu Ser Cys Arg His Lys Leu 
            420                 425                 430         


Tyr Thr Ile Met Cys Phe Ile Leu Val Ala Glu Leu Asp Ala His Glu 
        435                 440                 445             


Ser Ile Arg Asp Asn Met Val Ala Glu Leu Arg Ala Asn Met Asp Gly 
    450                 455                 460                 


Asp Asp Gly Arg Asp Ala Ile Tyr Glu Lys Tyr Ala Lys Asp Ile Tyr 
465                 470                 475                 480 


His Ile Val Lys Asp Lys Leu Leu Ala Met Gln Lys Val Phe Asp Glu 
                485                 490                 495     


Glu Leu Val Pro Val Lys Val Asp Gly Lys Asn Asp Pro Gln Gln Phe 
            500                 505                 510         


Thr His Gly Lys Leu Ser Lys Lys Glu Ile Glu Ser Phe Cys Leu Ser 
        515                 520                 525             


Asp Lys Asn Thr Ser Asp Ile Ala Lys Val Val Tyr Phe Leu Cys Asn 
    530                 535                 540                 


Phe Leu Asp Gly Lys Glu Ile Asn Glu Leu Cys Cys Ala Met Met Asn 
545                 550                 555                 560 


Lys Phe Asp Gly Ile Gly Asp Leu Ile Asp Thr Ala Lys Gln Cys Gly 
                565                 570                 575     


Glu Glu Val Lys Phe Ile Glu Glu Phe Ala Cys Leu Ser Asn Tyr Arg 
            580                 585                 590         


Lys Ile Thr Asn Asp Ile Arg Val Ala Lys Ser Ile Ser Lys Met Lys 
        595                 600                 605             


Asn Lys Val Asn Ile Asp Asn Asp Ile Ile Tyr Leu Asp Ala Ile Glu 
    610                 615                 620                 


Leu Leu Gly Arg Arg Ile Glu Lys Tyr Gln Lys Asp Glu Asn Gly Lys 
625                 630                 635                 640 


Ile Leu Leu Gly Thr Asp Gly Lys Arg Leu Tyr Thr Lys Glu Tyr Lys 
                645                 650                 655     


Asp Phe Asn Asp Met Phe Phe Asn Ala Gly Asn His Lys Val Arg Asn 
            660                 665                 670         


Phe Ile Ala Asn Ser Val Met Lys Ser Lys Trp Phe Phe Tyr Val Val 
        675                 680                 685             


Arg Tyr Asn Lys Pro Ala Glu Cys Gln Ile Ile Met Arg Asn Lys Thr 
    690                 695                 700                 


Leu Val Lys Phe Thr Leu Asp Asp Leu Pro Asp Met Gln Ile Gln Arg 
705                 710                 715                 720 


Tyr Tyr Ser Ser Val Phe Gly Asp Asn Asn Met Pro Ala Val Asp Glu 
                725                 730                 735     


Met Arg Lys Leu Leu Leu Lys Lys Ile Asn Gln Phe Ser Val Arg Gly 
            740                 745                 750         


Phe Leu Asp Glu Ile Val Leu Met Ser Asp Glu Glu Ser Lys Arg Asn 
        755                 760                 765             


Lys Ser Ser Glu Lys Glu Gln Lys Lys Ser Leu Ile Arg Leu Tyr Leu 
    770                 775                 780                 


Thr Ile Ala Tyr Leu Ile Thr Lys Ser Met Val Lys Ile Asn Thr Arg 
785                 790                 795                 800 


Phe Ser Ile Ala Cys Ala Thr Tyr Glu Arg Asp Tyr Ala Leu Leu Cys 
                805                 810                 815     


Gln Ser Glu Met Lys Gly Gly Pro Trp Asp Gly Gly Ala Gln Ala Leu 
            820                 825                 830         


Ala Val Thr Arg Lys Phe Leu Asn His Asp Arg Glu Val Phe Asp Arg 
        835                 840                 845             


Tyr Cys Ala Arg Glu Ala Glu Ile Ala Arg Leu Pro Ile Glu Glu Arg 
    850                 855                 860                 


Lys Pro Leu Arg Lys Ala Asn Asp Lys Leu Leu Lys Gln Thr His Tyr 
865                 870                 875                 880 


Thr Asn His Ser Tyr Thr Tyr Ile Val Asn Asn Leu Asn Ser Phe Thr 
                885                 890                 895     


Asp Ile Asp Tyr Cys Ala Lys Asp Val Gly Leu Pro Ala Pro Asn Asp 
            900                 905                 910         


Lys Asn Asp Asn Ala Ser Ile Leu Gly Glu Met Arg Asn Asp Ile Ala 
        915                 920                 925             


His Leu Asn Ile Val His Asp Met Val Lys Tyr Ile Glu Glu Leu Lys 
    930                 935                 940                 


Asp Ile Ser Ser Tyr Tyr Ala Phe Tyr Cys Tyr Val Leu Gln Arg Arg 
945                 950                 955                 960 


Leu Val Gly Lys Asp Pro Asn Cys Gln Asn Lys Phe Lys Ala Lys Tyr 
                965                 970                 975     


Ala Lys Glu Leu Asn Asp Tyr Gly Thr Tyr Asn Lys Asn Leu Met Trp 
            980                 985                 990         


Met Leu Asn Leu Pro Phe Ala Tyr  Asn Leu Pro Arg Tyr  Lys Asn Leu 
        995                 1000                 1005             


Ser Ser  Glu Phe Leu Phe Tyr  Asp Met Glu Tyr Asn  Lys Lys Asp 
    1010                 1015                 1020             


Asp Glu  
    1025 


<210>  2830
<211>  918
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2830

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Gly Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Asn Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp 
    370                 375                 380                 


Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Gly Val Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ser Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu Arg 
785                 790                 795                 800 


Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr Arg 
                805                 810                 815     


Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu Lys 
            820                 825                 830         


Glu Tyr Ile Gly Asp Ile Cys Thr Val Asp Ser Tyr Phe Ser Ile Tyr 
        835                 840                 845             


His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr Lys 
    850                 855                 860                 


Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His Gly 
865                 870                 875                 880 


Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr Asn 
                885                 890                 895     


Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg Asn 
            900                 905                 910         


Glu Tyr Leu Thr Glu Lys 
        915             


<210>  2831
<211>  918
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2831

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Gly Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Asn Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp 
    370                 375                 380                 


Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Gly Val Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ser Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu Arg 
785                 790                 795                 800 


Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr Arg 
                805                 810                 815     


Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu Lys 
            820                 825                 830         


Glu Tyr Ile Gly Asp Ile Cys Thr Val Asp Ser Tyr Phe Ser Ile Tyr 
        835                 840                 845             


His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr Lys 
    850                 855                 860                 


Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His Gly 
865                 870                 875                 880 


Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr Asn 
                885                 890                 895     


Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg Asn 
            900                 905                 910         


Glu Tyr Leu Thr Glu Lys 
        915             


<210>  2832
<211>  960
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2832

Met Ala Lys Lys Leu Asn Ala Lys Glu Lys Arg Leu Leu Ser Gln Gln 
1               5                   10                  15      


Ala Gln Lys Asp Lys Tyr Lys Lys Met Glu Glu Glu Arg Gln Ala Ala 
            20                  25                  30          


Glu Gln Ala Arg Leu Ala Glu Glu Ala Arg Gln Lys Ala Glu Thr Glu 
        35                  40                  45              


Arg Lys Lys Lys Glu Ala Leu Glu Lys Glu Ala Arg Glu Lys Leu Glu 
    50                  55                  60                  


Lys Glu Leu Leu Glu Lys Asn Pro Ser Leu Lys Lys Val Lys Lys Ser 
65                  70                  75                  80  


Lys Ala Lys Ala Ala Gly Leu Lys Ser Thr Phe Ala Ile Gly Asn Glu 
                85                  90                  95      


Leu Leu Met Thr Ser Phe Gly Lys Gly Asn Glu Ala Val Pro Glu His 
            100                 105                 110         


Tyr Ile Phe Glu Asn Gly Met Ile Ser Met Gln Asn Pro Pro Ala Phe 
        115                 120                 125             


Asp Val Glu Asn Arg Gly Thr Ser Phe Ser Ile Ala Gly Lys Asn Ala 
    130                 135                 140                 


Met Asn Ala Ile Ala Asp Asp Pro Arg Arg Thr Ser Lys Lys Val Ile 
145                 150                 155                 160 


Gly Glu Asp Leu Ile Gly Ala Lys Ser Ala Leu Glu Lys Arg Tyr Phe 
                165                 170                 175     


Gly Lys Thr Phe Glu Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
            180                 185                 190         


Leu Asp Ile Glu Lys Ile Leu Ser Lys His Ile Asn Asn Ile Val Phe 
        195                 200                 205             


Ser Ile Asn Asn Ile Arg Gly Ile Ala Asp Pro Glu Arg Asp Asp Leu 
    210                 215                 220                 


Ile Gly Tyr Met Ser Leu Arg Asp Ser Tyr Glu Tyr Phe Met Asp Glu 
225                 230                 235                 240 


Lys Asn Glu Lys Arg Lys Val Leu Arg Glu Ser Tyr Arg Lys Leu Phe 
                245                 250                 255     


Lys Ser Ser Arg Leu Ser Tyr Phe Gly Ser Ala Phe Tyr Val Glu Lys 
            260                 265                 270         


Gln Ser Thr Gln Lys Lys Lys Ser Gly Gln Lys Asn Phe Glu Leu Arg 
        275                 280                 285             


Asn Glu Lys Asp Cys Tyr Tyr Met Leu Ala Leu Leu Gly Glu Leu Arg 
    290                 295                 300                 


Gln Val Leu Ala His Ser Ser Ala Gln Lys Gln Gly Lys Glu Gln Thr 
305                 310                 315                 320 


Glu Ala Arg Ser Ser Val Tyr Asn Leu Arg Thr Val Gly Asn Asn Asp 
                325                 330                 335     


Met Arg Lys Ile Leu Asn Ser Leu Tyr Ala Glu Arg Val Asp Ala Leu 
            340                 345                 350         


Asn Glu Asn Phe Met Asn Tyr Ala Lys Lys Asp Leu Thr Ile Leu Phe 
        355                 360                 365             


Gly Ile Met Asp Ala Ser Ser Tyr Glu Lys Lys Ala Glu Ile Ala Arg 
    370                 375                 380                 


Asp Phe Tyr Asp Phe Thr Val Arg Lys Ser Tyr Lys Asn Ile Gly Phe 
385                 390                 395                 400 


Ser Ile Lys Lys Ile Arg Glu Arg Met Met Asp Cys Phe Phe Ala Asn 
                405                 410                 415     


Val Lys Glu Ile Thr Pro Asp Ser Pro Asp Phe Gln Ser Val Arg Gln 
            420                 425                 430         


Lys Phe Tyr Lys Ile Leu Asp Phe Leu Leu Phe Thr Tyr Tyr Lys Asp 
        435                 440                 445             


Asn Lys Glu Glu Thr Lys Lys Ile Ile Ala Ala Leu Arg Ala Ser Leu 
    450                 455                 460                 


Thr Glu Leu Glu Lys Glu Leu Phe Tyr Gln Lys Gln Ala Asn Ile Leu 
465                 470                 475                 480 


Trp Asn Lys Met Gln Met Val Val Thr Glu Gln Ile Tyr Pro Arg Thr 
                485                 490                 495     


Lys Gly Ser Ala Ile Gln Asn Leu Ile Ala Asp Pro Glu Ile Ser Ala 
            500                 505                 510         


Asp Met Leu Lys Gly Val Met Ile Thr Pro Glu Ser Val Asp Tyr Phe 
        515                 520                 525             


Ser Lys Met Ile Tyr Leu Leu Thr Leu Phe Ile Asp Gly Lys Glu Ile 
    530                 535                 540                 


Asn Asp Leu Leu Thr Thr Met Ile Asn Lys Phe Glu Asn Ile Ala Ser 
545                 550                 555                 560 


Phe Val Ser Val Leu Lys Asp Arg Gly Leu Pro Cys Asn Phe Arg Asn 
                565                 570                 575     


Asp Tyr Ser Val Phe Asn Asn Ala Leu Lys Ile Ser Ala Glu Leu Arg 
            580                 585                 590         


Glu Ile Asn Ser Phe Ala Arg Met Glu Lys Ala Thr Pro Gly Ala Lys 
        595                 600                 605             


Lys Gln Met Phe Leu Asp Ala Ala Ile Ile Leu Gly Ser Asn Glu Ser 
    610                 615                 620                 


Ala Glu Glu Leu Ser Glu Tyr Phe Asp Glu Met Leu Asp Lys Gln Lys 
625                 630                 635                 640 


Gly Lys Arg Thr Pro Gly Gly Lys Lys Asp Met Gly Phe Arg Asn Phe 
                645                 650                 655     


Leu Ile Lys Asn Val Ile Glu Ser Asp Arg Phe His Tyr Leu Ile Arg 
            660                 665                 670         


Tyr Gly His Pro Leu His Ile Arg Lys Leu Ala Glu Asn Lys Asn Val 
        675                 680                 685             


Ile Ala Phe Val Leu Lys Gln Ile Pro Glu Pro Gln Ile Asp Arg Tyr 
    690                 695                 700                 


Cys Lys Ile Cys Ala Leu Pro Ala Glu Ser Asn Phe Ala Gln Lys Ile 
705                 710                 715                 720 


Leu Arg Leu Thr Asp Leu Ile Ala Glu Met Asn Phe Arg Gln Phe Glu 
                725                 730                 735     


Asn Val Arg Gln Thr Glu Lys Asn Glu Gln Lys Gln Ile Leu Gln Gly 
            740                 745                 750         


Ile Leu Ser Leu Tyr Leu Thr Val Leu Tyr Leu Leu Thr Lys Asn Leu 
        755                 760                 765             


Val Tyr Val Asn Ser Arg Tyr Phe Leu Ala Phe His Cys Leu Glu Arg 
    770                 775                 780                 


Asp Thr Glu Leu Leu Gly Ser Gln Ala Gly His Lys Asn Ala Glu Lys 
785                 790                 795                 800 


Gln Leu Ile Ala Ser Tyr Ser Ala Leu Thr Gln Gln Phe Leu Asp Glu 
                805                 810                 815     


Gly Lys Leu Asn Arg His Ala Arg Glu Tyr Leu Thr Val Asn Ile Gln 
            820                 825                 830         


Asn Ser Asp Asp Trp Thr Ile Ala Gln Tyr Arg Asn Asn Ala Ala His 
        835                 840                 845             


Leu Asn Ala Ile Arg Asn Ala His Leu Tyr Ile Arg Glu Met Lys Ser 
    850                 855                 860                 


Val Arg Ser Tyr Phe Glu Leu Tyr His Tyr Leu Thr Gln Arg Ala Leu 
865                 870                 875                 880 


Leu Asp Lys Tyr Glu Asn Val Pro Tyr His Pro Gln Val Asn Glu Lys 
                885                 890                 895     


Thr Leu Lys Tyr Phe Glu Leu Leu Lys Glu Asn Gly Trp Tyr Cys Lys 
            900                 905                 910         


Asp Phe Val Lys Ala Leu Asn Val Pro Phe Gly Tyr Asn Leu Pro Arg 
        915                 920                 925             


Tyr Lys Asn Leu Ser Ile Asp Ala Leu Phe Asp Lys Asp Arg Pro Gln 
    930                 935                 940                 


Glu Glu Asp Glu Asn His Leu Tyr Thr Cys Gln Asn Ile Lys Lys Ser 
945                 950                 955                 960 


<210>  2833
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2833

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Gln Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Ser Val Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Gln Asn Thr Tyr Tyr Ile 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val 
            260                 265                 270         


Ser Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu 
    290                 295                 300                 


Tyr Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Val Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Ile Ala Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Leu Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Asn Arg Asp Glu Ser Pro Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asp Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  2834
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2834

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asp Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Phe Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Lys Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Ala Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Leu Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr Tyr Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Leu Ser Glu His Ser Glu Tyr Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Asn Ser Lys Lys Val Tyr Arg Glu Cys Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ala Lys Leu Trp Val Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Lys Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2835
<211>  981
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2835

Val Glu Lys Arg Leu Asn Glu Ser Leu Gln Lys Gln Arg Glu Gln Gln 
1               5                   10                  15      


Thr Val Thr Asp Glu Ser Glu Arg Lys Lys Lys Pro Leu Lys Ser Gly 
            20                  25                  30          


Ala Lys Ala Ala Gly Leu Lys Ser Val Phe Val Leu Ser Glu Gly Lys 
        35                  40                  45              


Glu Leu Leu Thr Ser Phe Gly Arg Gly Asn Glu Ala Val Pro Glu Lys 
    50                  55                  60                  


Arg Val Thr Gly Gly Thr Ile Ala Asn Ala Arg Thr Asp Asn Lys Glu 
65                  70                  75                  80  


Ala Phe Ser Ala Ala Leu Gln Asn Lys Arg Phe Glu Val Phe Gly Arg 
                85                  90                  95      


Thr Ala Gly Ser Ser Asp Asp Pro Leu Ala Val Ser Arg Ala Pro Gly 
            100                 105                 110         


Gln Asp Leu Ile Gly Ala Lys Thr Ala Leu Glu Glu Arg Tyr Phe Gly 
        115                 120                 125             


Arg Ala Phe Ala Asp Asn Ile His Met Gln Val Ile Tyr Ala Ile Gln 
    130                 135                 140                 


Asp Ile Asn Lys Ile Leu Ala Val His Ala Asn Asn Ile Val Tyr Thr 
145                 150                 155                 160 


Leu Asn Asn Leu Asp Arg Glu Ala Asp Pro Glu Thr Asp Asp Phe Ile 
                165                 170                 175     


Gly Ser Gly Tyr Leu Thr Leu Lys Asn Thr Phe Glu Thr Tyr Cys Asp 
            180                 185                 190         


Pro Ala Ala Leu Asn Glu Arg Glu Arg Glu Lys Val Thr Val Ser Lys 
        195                 200                 205             


Gln His Phe Asp Ala Phe Met Gln Asn Pro Arg Leu Ala Tyr Tyr Gly 
    210                 215                 220                 


Asn Ala Phe Phe Arg Lys Leu Ser Lys Ala Glu Arg Leu Ala Arg Gly 
225                 230                 235                 240 


Arg Glu Ile Phe Asp Lys Glu Ser Pro Glu Arg Arg Gln Glu Ile Leu 
                245                 250                 255     


Gly Ser Arg Gly Lys Asn Lys Ser Val Asp Asp Glu Ile Arg Ala Leu 
            260                 265                 270         


Ala Pro Glu Trp Val Lys Arg Glu Glu Arg Asp Val Tyr Ser Glu Leu 
        275                 280                 285             


Val Leu Met Ser Glu Leu Arg Gln Ser Cys Phe His Gly Gln Gln Lys 
    290                 295                 300                 


Asn Ser Ala Arg Ile Phe Arg Leu Asp Asn Asp Leu Gly Pro Gly Val 
305                 310                 315                 320 


Asp Gly Ala Arg Glu Leu Leu Asp Arg Leu Tyr Ala Glu Lys Ile Asn 
                325                 330                 335     


Asp Leu Arg Ser Phe Asp Lys Thr Ser Ala Ser Ser Asn Phe Arg Leu 
            340                 345                 350         


Leu Phe Asn Ala Tyr His Ala Asp Asn Glu Lys Lys Lys Glu Leu Ala 
        355                 360                 365             


Gln Glu Phe Tyr Arg Phe Ser Val Leu Lys Val Ser Lys Asn Thr Gly 
    370                 375                 380                 


Phe Ser Ile Arg Thr Leu Arg Glu Lys Ile Ile Glu Asp His Ala Ala 
385                 390                 395                 400 


Gln Tyr Arg Asp Lys Ile Tyr Asp Ser Met Arg Lys Lys Leu Phe Ser 
                405                 410                 415     


Thr Phe Asp Phe Phe Leu Trp Arg Phe Tyr Glu Glu Arg Glu Asp Glu 
            420                 425                 430         


Ala Glu Glu Leu Arg Ala Cys Leu Arg Ala Ala Arg Ser Asp Glu Glu 
        435                 440                 445             


Lys Glu Gln Ile Tyr Ala Glu Ala Ala Ala Ser Cys Trp Pro Ser Val 
    450                 455                 460                 


Lys Pro Phe Val Glu Ser Val Ala Ala Thr Leu Cys Asp Val Val Lys 
465                 470                 475                 480 


Gly Arg Thr Lys Leu Asn Lys Leu Lys Leu Ser Ala Asp Glu Ser Thr 
                485                 490                 495     


Leu Val Arg Asn Ala Ile Asp Gly Val Arg Ile Ser Pro Arg Ala Ser 
            500                 505                 510         


Tyr Phe Thr Lys Leu Ile Tyr Leu Met Thr Leu Phe Leu Asp Gly Lys 
        515                 520                 525             


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile His Ala Phe Glu Asn Ile 
    530                 535                 540                 


Asp Ser Phe Leu Ser Val Leu Gly Ser Glu Arg Leu Glu Arg Thr Phe 
545                 550                 555                 560 


Asp Ala Asn Tyr Arg Ile Phe Ala Asp Ser Gly Val Ile Ala Gln Glu 
                565                 570                 575     


Leu Arg Ala Val Asn Ser Phe Ala Arg Met Thr Thr Glu Pro Phe Asn 
            580                 585                 590         


Ser Lys Leu Val Met Phe Glu Asp Ala Ala Gln Leu Phe Gly Met Ser 
        595                 600                 605             


Gly Gly Leu Val Glu His Ala Glu Glu Leu Arg Glu Tyr Leu Asp Asn 
    610                 615                 620                 


Lys Met Leu Asp Lys Thr Lys Leu Arg Leu Leu Pro Asp Gly Lys Val 
625                 630                 635                 640 


Asp Thr Gly Phe Arg Asn Phe Ile Ile Ser Asn Val Thr Glu Ser Arg 
                645                 650                 655     


Arg Phe Arg Tyr Leu Val Arg Tyr Cys Glu Pro Arg Ala Val Arg Asp 
            660                 665                 670         


Tyr Met Ser Cys Arg Pro Leu Ile Arg Leu Thr Leu Arg Asp Met Pro 
        675                 680                 685             


Asp Thr Ile Leu Arg Arg Tyr Tyr Glu Gln Ser Val Gly Ala Ala Thr 
    690                 695                 700                 


Val Asp Arg Glu Arg Ile Leu Asp Thr Leu Ala Asp Lys Leu Leu Ser 
705                 710                 715                 720 


Leu Arg Phe Thr Asp Phe Glu Asn Val Asn Gln Arg Ala Asn Ala Glu 
                725                 730                 735     


Arg Asn Arg Glu Lys Gln Lys Met Met Gly Ile Ile Ser Leu Tyr Leu 
            740                 745                 750         


Asn Val Ala Tyr Gln Ile Val Lys Asn Leu Val Tyr Val Asn Ala Arg 
        755                 760                 765             


Tyr Thr Met Ala Tyr His Cys Ala Glu Arg Asp Thr Glu Leu Leu Leu 
    770                 775                 780                 


Asn Ala Ala Gly Glu Gly Asn Leu Leu Arg Arg Asp Arg Ser Trp Pro 
785                 790                 795                 800 


Ala Arg Leu His Leu Pro Arg Arg Ala Leu Ala Arg Arg Arg Asp Arg 
                805                 810                 815     


Val Glu Val Met Glu Arg Asp Val Ala Arg Gly Pro Glu Ala Tyr Asn 
            820                 825                 830         


Arg Asp Glu Trp Leu Gly Leu Val Arg Thr Leu Arg Arg Glu Lys Arg 
        835                 840                 845             


Val Cys Asp Asn Leu His Asn Asn Tyr Ala Tyr Leu Cys Gly Ala Asp 
    850                 855                 860                 


Ala Glu Pro Gly Asp Ala Ser Leu Ser Leu Leu Phe Val Tyr Arg Asn 
865                 870                 875                 880 


Lys Ala Ala His Leu Ser Val Leu Asn Lys Gly Gly Arg Leu Ser Gly 
                885                 890                 895     


Asp Leu Lys Glu Ala Lys Ser Trp Phe Tyr Val Tyr His Phe Leu Met 
            900                 905                 910         


Gln Arg Val Leu Glu Glu Glu Phe Arg Asn Thr Gln Ala Leu Pro Glu 
        915                 920                 925             


Arg Leu Arg Glu Leu Leu Met Met Ala Glu Arg Tyr Arg Gly Cys Ser 
    930                 935                 940                 


Lys Asp Leu Ile Lys Val Leu Asn Leu Thr Phe Ala Tyr Asn Leu Pro 
945                 950                 955                 960 


Arg Tyr Lys Asn Leu Ser Ile Asp Gly Arg Phe Asp Lys Asn His Pro 
                965                 970                 975     


Asp Pro Ser Asp Glu 
            980     


<210>  2836
<211>  921
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2836

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Gly Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Asn Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu Tyr Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Val Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp 
    370                 375                 380                 


Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Ile Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Glu Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn Arg 
785                 790                 795                 800 


Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser 
                805                 810                 815     


Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg 
            820                 825                 830         


Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe 
        835                 840                 845             


Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp 
    850                 855                 860                 


Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys 
865                 870                 875                 880 


Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe 
                885                 890                 895     


Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe 
            900                 905                 910         


Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920     


<210>  2837
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2837

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Lys Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asn Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Asp Glu Ser His Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe Thr Asp 
    210                 215                 220                 


Pro Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Asn Ala Leu Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Pro Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp Asp Ile 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  2838
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2838

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Met Lys 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Ile Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Asn Arg Val Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2839
<211>  923
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2839

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Val Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Lys Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asp Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asp Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Lys Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Asn Ala 
            260                 265                 270         


Leu Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu His Glu 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Ile Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Asp Asp Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile 
        355                 360                 365             


Val Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg 
    370                 375                 380                 


Glu Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe 
                405                 410                 415     


Cys Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg 
            420                 425                 430         


Lys Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala 
        435                 440                 445             


Asp Glu Ala Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn 
    450                 455                 460                 


Ile Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala 
465                 470                 475                 480 


Asp Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala 
                485                 490                 495     


Ser Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe 
            500                 505                 510         


Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys 
        515                 520                 525             


Phe Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val 
    530                 535                 540                 


Asp Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser 
545                 550                 555                 560 


Gln Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met 
                565                 570                 575     


Arg Lys Pro Ala Ser Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu 
            580                 585                 590         


Thr Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu 
        595                 600                 605             


Ile Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn 
    610                 615                 620                 


Phe Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile 
625                 630                 635                 640 


Lys Tyr Ala Asn Ala Gln Lys Ile Arg Lys Val Ala Lys Asn Glu Lys 
                645                 650                 655     


Val Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg 
            660                 665                 670         


Tyr Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu 
        675                 680                 685             


Val Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp 
    690                 695                 700                 


Asp Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala 
705                 710                 715                 720 


Lys Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr 
                725                 730                 735     


Leu Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala 
            740                 745                 750         


Ile His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro 
        755                 760                 765             


Glu Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln 
    770                 775                 780                 


Thr Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys 
785                 790                 795                 800 


Asn Arg Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp 
                805                 810                 815     


Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val 
            820                 825                 830         


Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser 
        835                 840                 845             


Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg 
    850                 855                 860                 


Glu Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu 
865                 870                 875                 880 


Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser 
                885                 890                 895     


Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln 
            900                 905                 910         


Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920             


<210>  2840
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2840

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Ile Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Pro Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn His Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2841
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2841

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asp Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Phe Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Lys Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Ala Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Leu Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr Tyr Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Leu Ser Glu His Ser Glu Tyr Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Asn Ser Lys Lys Val Tyr Arg Glu Cys Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Leu Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ala Lys Leu Trp Val Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Pro Leu Glu Ala 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Ile Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2842
<211>  906
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2842

Met Glu Arg Glu Val Lys Lys Pro Pro Lys Lys Ser Leu Ala Lys Ala 
1               5                   10                  15      


Ala Gly Leu Lys Ser Thr Phe Val Ile Ser Pro Gln Glu Lys Glu Leu 
            20                  25                  30          


Ala Met Thr Ala Phe Gly Arg Gly Asn Asp Ala Leu Leu Gln Lys Arg 
        35                  40                  45              


Ile Val Asp Gly Val Val Arg Asp Val Ala Gly Glu Lys Gln Gln Phe 
    50                  55                  60                  


Gln Val Gln Arg Gln Asp Glu Ser Arg Phe Arg Leu Gln Asn Ser Arg 
65                  70                  75                  80  


Leu Ala Asp Arg Thr Val Thr Ala Asp Asp Pro Leu His Arg Ala Glu 
                85                  90                  95      


Val Pro His Arg Gln Pro Leu Gly Ala Gly Met Asp Gln Leu Arg Arg 
            100                 105                 110         


Lys Ala Val Leu Glu Gln Lys Tyr Phe Gly Arg Thr Phe Asp Asp Asn 
        115                 120                 125             


Ile His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile His Lys Met Leu 
    130                 135                 140                 


Ala Val Pro Ala Asn His Ile Val His Thr Leu Asn Leu Leu Gly Gly 
145                 150                 155                 160 


Tyr Gly Glu Met Asp Phe Val Gly Met Leu Pro Ala Gly Leu Pro Tyr 
                165                 170                 175     


Asp Lys Leu Arg Val Val Lys Lys Lys Asn Gly Asp Thr Val Asp Ile 
            180                 185                 190         


Lys Ala Asp Ile Ala Ala Tyr Ala Lys Arg Pro Gln Leu Ala Tyr Leu 
        195                 200                 205             


Gly Ala Ala Phe Tyr Asp Val Thr Pro Gly Lys Ser Lys Arg Asp Ala 
    210                 215                 220                 


Ala Arg Gly Arg Val Lys Arg Glu Gln Asp Val Tyr Thr Ile Leu Ser 
225                 230                 235                 240 


Leu Met Ser Leu Leu Arg Gln Phe Cys Ala His Asp Ser Val Arg Ile 
                245                 250                 255     


Trp Gly Gln Asn Thr Pro Ala Ala Leu Tyr His Leu Gln Ala Leu Pro 
            260                 265                 270         


Gln Asp Met Lys Asp Leu Leu Asp Asp Gly Trp Arg Arg Ala Leu Gly 
        275                 280                 285             


Gly Val Asn Asp His Phe Leu Asp Thr Asn Lys Val Asn Leu Leu Thr 
    290                 295                 300                 


Leu Phe Glu Tyr Tyr Gly Ala Glu Thr Lys Gln Ala Arg Val Ala Leu 
305                 310                 315                 320 


Thr Gln Asp Phe Tyr Arg Phe Val Val Leu Lys Glu Gln Lys Asn Met 
                325                 330                 335     


Gly Phe Ser Leu Arg Arg Leu Arg Glu Glu Leu Leu Lys Leu Pro Asp 
            340                 345                 350         


Ala Ala Tyr Leu Thr Gly Gln Glu Tyr Asp Ser Val Arg Gln Lys Leu 
        355                 360                 365             


Tyr Met Leu Leu Asp Phe Leu Leu Cys Arg Leu Tyr Ala Gln Glu Arg 
    370                 375                 380                 


Ala Asp Arg Cys Glu Glu Leu Val Ser Ala Leu Arg Cys Ala Leu Ser 
385                 390                 395                 400 


Asp Glu Glu Lys Asp Ala Val Tyr Gln Ala Glu Ala Ala Ala Leu Trp 
                405                 410                 415     


Gln Ala Leu Gly Asp Thr Leu Arg Arg Glu Leu Leu Pro Leu Leu Lys 
            420                 425                 430         


Gly Lys Lys Leu Gln Asp Lys Asp Lys Lys Lys Pro Asp Glu Leu Gly 
        435                 440                 445             


Leu Ser Arg Asp Val Leu Asp Gly Val Leu Phe Arg Pro Ala Gln Gln 
    450                 455                 460                 


Gly Asn Arg Ala Asn Ala Asp Tyr Phe Cys Arg Leu Met His Leu Ser 
465                 470                 475                 480 


Thr Trp Phe Met Asp Gly Lys Glu Ile Asn Thr Leu Leu Thr Thr Leu 
                485                 490                 495     


Ile Ser Lys Leu Glu Asn Ile Asp Ser Leu Arg Ser Val Leu Glu Ser 
            500                 505                 510         


Met Gly Leu Ala Cys Ser Phe Val Pro Ala Tyr Ala Met Phe Asp His 
        515                 520                 525             


Ser Arg Tyr Ile Ala Gly Gln Leu Arg Val Val Asn Asn Ile Ala Arg 
    530                 535                 540                 


Met Arg Lys Pro Ala Ile Gly Ala Lys Arg Glu Met Tyr Arg Ala Ala 
545                 550                 555                 560 


Val Val Leu Leu Gly Val Asp Ser Pro Glu Ala Ala Ala Ala Ile Thr 
                565                 570                 575     


Asp Asp Leu Leu Gln Ile Asp Pro Glu Thr Gly Lys Val Arg Pro Arg 
            580                 585                 590         


Gly Asp Ser Ala Arg Asp Thr Gly Leu Arg Asn Phe Ile Ala Asn Asn 
        595                 600                 605             


Val Val Glu Ser Arg Arg Phe Thr Tyr Leu Leu Arg Tyr Met Thr Pro 
    610                 615                 620                 


Glu Gln Ala Arg Val Leu Ala Gln Asn Glu Lys Leu Ile Ala Phe Val 
625                 630                 635                 640 


Leu Ser Thr Val Pro Asp Thr Gln Leu Glu Arg Tyr Cys Arg Thr Cys 
                645                 650                 655     


Gly Arg Glu Asp Ile Thr Gly Arg Pro Ala Gln Ile Arg Tyr Leu Thr 
            660                 665                 670         


Ala Gln Ile Met Gly Val Arg Tyr Glu Ser Phe Thr Asp Val Glu Gln 
        675                 680                 685             


Arg Gly Arg Gly Asp Asn Pro Arg Lys Glu Arg Tyr Lys Ala Leu Ile 
    690                 695                 700                 


Gly Leu Tyr Leu Thr Val Leu Tyr Leu Ala Val Lys Asn Met Val Asn 
705                 710                 715                 720 


Cys Asn Ala Arg Tyr Val Ile Ala Phe Tyr Cys Arg Asp Arg Asp Thr 
                725                 730                 735     


Ala Leu Tyr Gln Lys Glu Val Cys Trp Tyr Asp Leu Glu Glu Asp Lys 
            740                 745                 750         


Lys Ser Gly Lys Gln Arg Gln Val Glu Asp Tyr Thr Ala Leu Thr Arg 
        755                 760                 765             


Tyr Phe Val Ser Gln Gly Tyr Leu Asn Arg His Ala Cys Gly Tyr Leu 
    770                 775                 780                 


Arg Ser Asn Met Asn Gly Ile Ser Asn Gly Leu Leu Val Ala Tyr Arg 
785                 790                 795                 800 


Asn Ala Val Asp His Leu Asn Val Ile Pro Pro Leu Gly Ser Leu Ser 
                805                 810                 815     


Arg Asp Ile Gly Arg Val Asp Ser Tyr Phe Ala Leu Tyr His Tyr Ala 
            820                 825                 830         


Val Gln Gln Tyr Leu Asn Gly Arg Tyr Tyr Arg Lys Thr Pro Arg Glu 
        835                 840                 845             


Gln Glu Leu Phe Ala Ala Met Ala Gln His Arg Thr Trp Cys Ser Asp 
    850                 855                 860                 


Leu Val Lys Ala Leu Asn Thr Pro Phe Gly Tyr Asn Leu Ala Arg Tyr 
865                 870                 875                 880 


Lys Asn Leu Ser Ile Asp Gly Leu Phe Asp Arg Glu Gly Asp His Val 
                885                 890                 895     


Val Arg Glu Asp Gly Glu Lys Pro Ala Glu 
            900                 905     


<210>  2843
<211>  924
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2843

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Phe Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Leu Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Leu Ser Glu His Ser Glu Tyr Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asp Asn Ser Lys Lys Val Tyr Arg Glu Cys Arg Glu Thr Leu 
305                 310                 315                 320 


Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile 
                325                 330                 335     


Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly 
            340                 345                 350         


Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu 
        355                 360                 365             


Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys 
    370                 375                 380                 


Ile Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser 
385                 390                 395                 400 


Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn 
                405                 410                 415     


Tyr Tyr Arg Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu 
            420                 425                 430         


Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu 
        435                 440                 445             


Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala 
    450                 455                 460                 


Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met 
465                 470                 475                 480 


Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp 
                485                 490                 495     


Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp 
            500                 505                 510         


Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp 
        515                 520                 525             


Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val 
    530                 535                 540                 


Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg 
545                 550                 555                 560 


Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys 
                565                 570                 575     


Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile 
            580                 585                 590         


Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu 
        595                 600                 605             


Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile 
    610                 615                 620                 


Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr 
625                 630                 635                 640 


Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val 
                645                 650                 655     


Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr 
            660                 665                 670         


Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys 
        675                 680                 685             


Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe 
    690                 695                 700                 


Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu 
705                 710                 715                 720 


Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu 
                725                 730                 735     


Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His 
            740                 745                 750         


Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu 
        755                 760                 765             


Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu 
    770                 775                 780                 


Cys Glu Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys 
785                 790                 795                 800 


Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala 
                805                 810                 815     


Asp Ser Asn Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr 
            820                 825                 830         


Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp 
        835                 840                 845             


Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys 
    850                 855                 860                 


Arg Glu Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp 
865                 870                 875                 880 


Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn 
                885                 890                 895     


Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu 
            900                 905                 910         


Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 


<210>  2844
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2844

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Ser Ser Asn Ile Glu Leu Arg Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Lys Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe Thr Asn 
    210                 215                 220                 


Pro Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Lys Asn Ile Arg Lys 
225                 230                 235                 240 


Ser Leu Arg Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu His Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Ile Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Lys Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Arg Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  2845
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2845

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asp Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Phe Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Lys Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Ala Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Leu Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr Tyr Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Leu Ser Glu His Ser Glu Tyr Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Asn Ser Lys Lys Val Tyr Arg Glu Cys Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Leu Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ala Lys Leu Trp Val Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Pro Leu Glu Ala 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Ile Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2846
<211>  954
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2846

Met Gly Lys Lys Ile His Ala Arg Asp Leu Arg Glu Gln Arg Lys Thr 
1               5                   10                  15      


Asp Arg Thr Glu Lys Phe Ala Asp Gln Asn Lys Lys Arg Glu Ala Glu 
            20                  25                  30          


Arg Ala Val Gln Lys Lys Asp Ala Ala Val Ser Val Lys Ser Val Ser 
        35                  40                  45              


Ser Val Ser Ser Lys Lys Asp Asn Val Thr Lys Ser Met Ala Lys Ala 
    50                  55                  60                  


Ala Gly Val Lys Ser Val Phe Ala Val Gly Asn Thr Val Tyr Met Thr 
65                  70                  75                  80  


Ser Phe Gly Arg Gly Asn Asp Ala Val Leu Glu Gln Lys Ile Val Asp 
                85                  90                  95      


Thr Ser His Glu Pro Leu Asn Ile Asp Asp Pro Ala Tyr Gln Leu Asn 
            100                 105                 110         


Val Val Thr Met Asn Gly Tyr Ser Val Thr Gly His Arg Gly Glu Thr 
        115                 120                 125             


Val Ser Ala Val Thr Asp Asn Pro Leu Arg Arg Phe Asn Gly Gly Lys 
    130                 135                 140                 


Lys Asp Glu Pro Glu Gln Ser Val Pro Thr Asp Met Leu Cys Leu Lys 
145                 150                 155                 160 


Pro Thr Leu Glu Lys Lys Phe Phe Gly Lys Glu Phe Asn Asp Asn Ile 
                165                 170                 175     


His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala 
            180                 185                 190         


Val Tyr Ser Thr Asn Ala Ile Tyr Ala Leu Asn Asn Met Ser Ala Asp 
        195                 200                 205             


Glu Asn Ile Glu Asn Ser Asp Phe Phe Met Lys Arg Thr Thr Asp Glu 
    210                 215                 220                 


Thr Phe Asp Asp Phe Glu Lys Lys Lys Glu Ser Thr Asn Ser Arg Glu 
225                 230                 235                 240 


Lys Ala Asp Phe Asp Ala Phe Glu Lys Phe Ile Gly Asn Tyr Arg Leu 
                245                 250                 255     


Ala Tyr Phe Ala Asp Ala Phe Tyr Val Asn Lys Lys Asn Pro Lys Gly 
            260                 265                 270         


Lys Ala Lys Asn Val Leu Arg Glu Asp Lys Glu Leu Tyr Ser Val Leu 
        275                 280                 285             


Thr Leu Ile Gly Lys Leu Arg His Trp Cys Val His Ser Glu Asp Gly 
    290                 295                 300                 


Arg Ala Glu Phe Trp Leu Tyr Lys Leu Asp Glu Leu Lys Asp Asp Phe 
305                 310                 315                 320 


Lys Asn Val Leu Asp Val Val Tyr Asn Arg Pro Val Glu Glu Ile Asn 
                325                 330                 335     


Asn Arg Phe Ile Glu Asn Asn Lys Val Asn Ile Gln Ile Leu Gly Ser 
            340                 345                 350         


Val Tyr Lys Asn Thr Asp Ile Ala Glu Leu Val Arg Ser Tyr Tyr Glu 
        355                 360                 365             


Phe Leu Ile Thr Lys Lys Tyr Lys Asn Met Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Ser Met Leu Glu Gly Lys Gly Tyr Ala Asp Lys Glu Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Asn Lys Leu Tyr Gln Met Thr Asp Phe Ile Leu Tyr 
                405                 410                 415     


Thr Gly Tyr Ile Asn Glu Asp Ser Asp Arg Ala Asp Asp Leu Val Asn 
            420                 425                 430         


Thr Leu Arg Ser Ser Leu Lys Glu Asp Asp Lys Thr Thr Val Tyr Cys 
        435                 440                 445             


Lys Glu Ala Asp Tyr Leu Trp Lys Lys Tyr Arg Glu Ser Ile Arg Glu 
    450                 455                 460                 


Val Ala Asp Ala Leu Asp Val Asp Asn Ile Lys Asn Leu Ser Gly Ser 
465                 470                 475                 480 


Asn Ile Glu Ile Arg Asp Asn Glu Leu Arg Lys Cys Phe Ile Ser Tyr 
                485                 490                 495     


Ala Asp Ser Val Ser Glu Phe Thr Lys Leu Ile Tyr Leu Leu Thr Arg 
            500                 505                 510         


Phe Leu Ser Gly Lys Glu Ile Asn Asp Leu Val Thr Thr Leu Ile Asn 
        515                 520                 525             


Lys Phe Asp Asn Ile Arg Ser Phe Leu Glu Ile Met Asp Glu Leu Gly 
    530                 535                 540                 


Leu Asp Arg Thr Phe Thr Ala Glu Tyr Ser Phe Phe Glu Gly Ser Thr 
545                 550                 555                 560 


Lys Tyr Leu Ala Glu Leu Val Glu Leu Asn Ser Phe Val Lys Ser Cys 
                565                 570                 575     


Ser Phe Asp Ile Asn Ala Lys Arg Thr Met Tyr Arg Asp Ala Leu Asp 
            580                 585                 590         


Ile Leu Gly Ile Lys Ser Gly Lys Thr Glu Glu Asp Ile Glu Lys Met 
        595                 600                 605             


Ile Asp Asn Ile Leu Gln Ile Asp Ala Asn Gly Asp Lys Lys Leu Lys 
    610                 615                 620                 


Lys Asn Asn Gly Leu Arg Asn Phe Ile Ala Ser Asn Val Ile Asp Ser 
625                 630                 635                 640 


Asn Arg Phe Lys Tyr Leu Val Arg Tyr Gly Asn Pro Lys Lys Ile Arg 
                645                 650                 655     


Glu Thr Ala Lys Cys Lys Pro Ala Val Arg Phe Val Leu Asn Glu Ile 
            660                 665                 670         


Pro Asp Ala Gln Ile Glu Arg Tyr Tyr Glu Ala Cys Cys Pro Lys Asn 
        675                 680                 685             


Thr Ala Leu Cys Ser Ala Asn Lys Arg Arg Glu Lys Leu Ala Asp Met 
    690                 695                 700                 


Ile Ala Glu Ile Lys Phe Glu Asn Phe Ser Asp Ala Gly Asn Tyr Gln 
705                 710                 715                 720 


Lys Ala Asn Val Thr Ser Arg Thr Ser Glu Ala Glu Ile Lys Arg Lys 
                725                 730                 735     


Asn Gln Ala Ile Ile Arg Leu Tyr Leu Thr Val Met Tyr Ile Met Leu 
            740                 745                 750         


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Phe His Cys 
        755                 760                 765             


Val Glu Arg Asp Thr Lys Leu Tyr Ala Glu Ser Gly Leu Glu Val Gly 
    770                 775                 780                 


Asn Ile Glu Lys Asn Lys Thr Asn Leu Thr Met Ala Val Met Gly Val 
785                 790                 795                 800 


Lys Leu Glu Asn Gly Thr Ile Lys Thr Glu Phe Asp Lys Ser Leu Ala 
                805                 810                 815     


Glu Asn Ala Ala Asn Arg Tyr Leu Arg Asn Ala Arg Trp Tyr Lys Leu 
            820                 825                 830         


Ile Leu Asp Asn Leu Lys Lys Ser Glu Arg Ala Val Val Thr Glu Phe 
        835                 840                 845             


Arg Asn Thr Val Cys His Leu Asn Ala Ile Arg Asn Ile Asn Ile Asn 
    850                 855                 860                 


Ile Lys Glu Ile Lys Glu Val Glu Asn Tyr Phe Ala Leu Tyr His Tyr 
865                 870                 875                 880 


Leu Ile Gln Lys His Leu Glu Asn Arg Phe Ala Asp Lys Lys Val Glu 
                885                 890                 895     


Arg Asp Thr Gly Asp Phe Ile Ser Lys Leu Glu Glu His Lys Thr Tyr 
            900                 905                 910         


Cys Lys Asp Phe Val Lys Ala Tyr Cys Thr Pro Phe Gly Tyr Asn Leu 
        915                 920                 925             


Val Arg Tyr Lys Asn Leu Thr Ile Asp Gly Leu Phe Asp Lys Asn Tyr 
    930                 935                 940                 


Pro Gly Lys Asp Asp Ser Asp Lys Gln Lys 
945                 950                 


<210>  2847
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2847

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asn Ser Ser Asn Ile Glu Leu Cys Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Ile Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Asp Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Ile Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Gly Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Tyr Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ile Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp Asp Thr 
    850                 855                 860                 


Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  2848
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2848

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asp Tyr Asn 
                85                  90                  95      


Gln Thr Gln Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val 
    210                 215                 220                 


Phe Thr Asp Pro Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe 
                325                 330                 335     


Ile Glu Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Ser Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Thr Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ile Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2849
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2849

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Met Lys 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Ile Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Asn Arg Val Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2850
<211>  926
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2850

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asp Asp Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Ser Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Phe Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Asp Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Lys Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Cys Val Phe His Asp Lys Ser Ser Lys Leu His Glu 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe 
                325                 330                 335     


Ile Glu Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Asp Asp Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile 
        355                 360                 365             


Val Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg 
    370                 375                 380                 


Glu Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe 
                405                 410                 415     


Cys Asn Tyr Tyr Arg Asn Asp Val Ala Val Gly Glu Ala Leu Val Arg 
            420                 425                 430         


Lys Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala 
        435                 440                 445             


Asp Glu Ala Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn 
    450                 455                 460                 


Ile Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala 
465                 470                 475                 480 


Asp Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala 
                485                 490                 495     


Ser Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe 
            500                 505                 510         


Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys 
        515                 520                 525             


Phe Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val 
    530                 535                 540                 


Asp Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser 
545                 550                 555                 560 


Gln Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met 
                565                 570                 575     


Arg Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu 
            580                 585                 590         


Thr Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu 
        595                 600                 605             


Ile Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn 
    610                 615                 620                 


Phe Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile 
625                 630                 635                 640 


Lys Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys 
                645                 650                 655     


Val Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg 
            660                 665                 670         


Tyr Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu 
        675                 680                 685             


Ala Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp 
    690                 695                 700                 


Asp Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala 
705                 710                 715                 720 


Lys Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr 
                725                 730                 735     


Leu Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala 
            740                 745                 750         


Ile His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro 
        755                 760                 765             


Glu Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln 
    770                 775                 780                 


Thr Leu Cys Glu Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe 
785                 790                 795                 800 


Leu Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn 
                805                 810                 815     


Asn Ala Asp Ser Ile Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His 
            820                 825                 830         


Leu Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr 
        835                 840                 845             


Val Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile 
    850                 855                 860                 


Thr Lys Arg Glu Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu 
865                 870                 875                 880 


Asp Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala 
                885                 890                 895     


Leu Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser 
            900                 905                 910         


Ile Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925     


<210>  2851
<211>  960
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2851

Met Ala Lys Lys Leu Asn Ala Lys Glu Lys Arg Leu Leu Ser Gln Gln 
1               5                   10                  15      


Ala Gln Lys Asp Lys Tyr Lys Lys Met Glu Glu Glu Arg Gln Ala Ala 
            20                  25                  30          


Glu Gln Ala Arg Leu Ala Glu Glu Ala Arg Gln Lys Ala Glu Thr Glu 
        35                  40                  45              


Arg Lys Lys Lys Glu Ala Leu Glu Lys Glu Ala Arg Glu Lys Leu Glu 
    50                  55                  60                  


Lys Glu Leu Leu Glu Lys Asn Pro Ser Leu Lys Lys Val Lys Lys Ser 
65                  70                  75                  80  


Lys Ala Lys Ala Ala Gly Leu Lys Ser Thr Phe Ala Ile Gly Asn Glu 
                85                  90                  95      


Leu Leu Met Thr Ser Phe Gly Lys Gly Asn Glu Ala Val Pro Glu His 
            100                 105                 110         


Tyr Ile Phe Glu Asn Gly Met Ile Ser Met Gln Asn Pro Pro Ala Phe 
        115                 120                 125             


Asp Val Glu Asn Arg Gly Thr Ser Phe Ser Ile Ala Gly Lys Asn Ala 
    130                 135                 140                 


Met Asn Ala Ile Ala Asp Asp Pro Arg Arg Thr Ser Lys Lys Val Ile 
145                 150                 155                 160 


Gly Glu Asp Leu Ile Gly Ala Lys Ser Ala Leu Glu Lys Arg Tyr Phe 
                165                 170                 175     


Gly Lys Thr Phe Glu Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
            180                 185                 190         


Leu Asp Ile Glu Lys Ile Leu Ser Lys His Ile Asn Asn Ile Val Phe 
        195                 200                 205             


Ser Ile Asn Asn Ile Arg Gly Ile Ala Asp Pro Glu Arg Asp Asp Leu 
    210                 215                 220                 


Ile Gly Tyr Met Ser Leu Arg Asp Ser Tyr Glu Tyr Phe Met Asp Glu 
225                 230                 235                 240 


Lys Asn Glu Lys Arg Lys Val Leu Arg Glu Ser Tyr Arg Lys Leu Phe 
                245                 250                 255     


Lys Ser Ser Arg Leu Ser Tyr Phe Gly Ser Ala Phe Tyr Val Glu Lys 
            260                 265                 270         


Gln Ser Thr Gln Lys Lys Lys Ser Gly Gln Lys Asn Phe Glu Leu Arg 
        275                 280                 285             


Asn Glu Lys Asp Cys Tyr Tyr Met Leu Ala Leu Leu Gly Glu Leu Arg 
    290                 295                 300                 


Gln Val Leu Ala His Ser Ser Ala Gln Lys Gln Gly Lys Glu Gln Thr 
305                 310                 315                 320 


Glu Ala Arg Ser Ser Val Tyr Asn Leu Arg Thr Val Gly Asn Asn Asp 
                325                 330                 335     


Met Arg Lys Ile Leu Asn Ser Leu Tyr Ala Glu Arg Val Asp Ala Leu 
            340                 345                 350         


Asn Glu Asn Phe Met Asn Tyr Ala Lys Lys Asp Leu Thr Ile Leu Phe 
        355                 360                 365             


Gly Ile Met Asp Ala Ser Ser Tyr Glu Lys Lys Ala Glu Ile Ala Arg 
    370                 375                 380                 


Asp Phe Tyr Asp Phe Thr Val Arg Lys Ser Tyr Lys Asn Ile Gly Phe 
385                 390                 395                 400 


Ser Ile Lys Lys Ile Arg Glu Arg Met Met Asp Cys Phe Phe Ala Asn 
                405                 410                 415     


Val Lys Glu Ile Thr Pro Asp Ser Pro Asp Phe Gln Ser Val Arg Gln 
            420                 425                 430         


Lys Phe Tyr Lys Ile Leu Asp Phe Leu Leu Phe Thr Tyr Tyr Lys Asp 
        435                 440                 445             


Asn Lys Glu Glu Thr Lys Lys Ile Ile Ala Ala Leu Arg Ala Ser Leu 
    450                 455                 460                 


Thr Glu Leu Glu Lys Glu Leu Phe Tyr Gln Lys Gln Ala Asn Ile Leu 
465                 470                 475                 480 


Trp Asn Lys Met Gln Met Val Val Thr Glu Gln Ile Tyr Pro Arg Thr 
                485                 490                 495     


Lys Gly Ser Ala Ile Gln Asn Leu Ile Ala Asp Pro Glu Ile Ser Ala 
            500                 505                 510         


Asp Met Leu Lys Gly Val Met Ile Thr Pro Glu Ser Val Asp Tyr Phe 
        515                 520                 525             


Ser Lys Met Ile Tyr Leu Leu Thr Leu Phe Ile Asp Gly Lys Glu Ile 
    530                 535                 540                 


Asn Asp Leu Leu Thr Thr Met Ile Asn Lys Phe Glu Asn Ile Ala Ser 
545                 550                 555                 560 


Phe Val Ser Val Leu Lys Asp Arg Gly Leu Pro Cys Asn Phe Arg Asn 
                565                 570                 575     


Asp Tyr Ser Val Phe Asn Asn Ala Leu Lys Ile Ser Ala Glu Leu Arg 
            580                 585                 590         


Glu Ile Asn Ser Phe Ala Arg Met Glu Lys Ala Thr Pro Gly Ala Lys 
        595                 600                 605             


Lys Gln Met Phe Leu Asp Ala Ala Ile Ile Leu Gly Ser Asn Glu Ser 
    610                 615                 620                 


Ala Glu Glu Leu Ser Glu Tyr Phe Asp Glu Met Leu Asp Lys Gln Lys 
625                 630                 635                 640 


Gly Lys Arg Thr Pro Gly Gly Lys Lys Asp Met Gly Phe Arg Asn Phe 
                645                 650                 655     


Leu Ile Lys Asn Val Ile Glu Ser Asp Arg Phe His Tyr Leu Ile Arg 
            660                 665                 670         


Tyr Gly His Pro Leu His Ile Arg Lys Leu Ala Glu Asn Lys Asn Val 
        675                 680                 685             


Ile Ala Phe Val Leu Lys Gln Ile Pro Glu Pro Gln Ile Asp Arg Tyr 
    690                 695                 700                 


Cys Lys Ile Cys Ala Leu Pro Ala Glu Ser Asn Phe Ala Gln Lys Ile 
705                 710                 715                 720 


Leu Arg Leu Thr Asp Leu Ile Ala Glu Met Asn Phe Arg Gln Phe Glu 
                725                 730                 735     


Asn Val Arg Gln Thr Glu Lys Asn Glu Gln Lys Gln Ile Leu Gln Gly 
            740                 745                 750         


Ile Leu Ser Leu Tyr Leu Thr Val Leu Tyr Leu Leu Thr Lys Asn Leu 
        755                 760                 765             


Val Tyr Val Asn Ser Arg Tyr Phe Leu Ala Phe His Cys Leu Glu Arg 
    770                 775                 780                 


Asp Thr Glu Leu Leu Gly Ser Gln Ala Gly His Lys Asn Ala Glu Lys 
785                 790                 795                 800 


Gln Leu Ile Ala Ser Tyr Ser Ala Leu Thr Gln Gln Phe Leu Asp Glu 
                805                 810                 815     


Gly Lys Leu Asn Arg His Ala Arg Glu Tyr Leu Thr Val Asn Ile Gln 
            820                 825                 830         


Asn Ser Asp Asp Trp Thr Ile Ala Gln Tyr Arg Asn Asn Ala Ala His 
        835                 840                 845             


Leu Asn Ala Ile Arg Asn Ala His Leu Tyr Ile Arg Glu Met Lys Ser 
    850                 855                 860                 


Val Arg Ser Tyr Phe Glu Leu Tyr His Tyr Leu Thr Gln Arg Ala Leu 
865                 870                 875                 880 


Leu Asp Lys Tyr Glu Asn Val Pro Tyr His Pro Gln Val Asn Glu Lys 
                885                 890                 895     


Thr Leu Lys Tyr Phe Glu Leu Leu Lys Glu Asn Gly Trp Tyr Cys Lys 
            900                 905                 910         


Asp Phe Val Lys Ala Leu Asn Val Pro Phe Gly Tyr Asn Leu Pro Arg 
        915                 920                 925             


Tyr Lys Asn Leu Ser Ile Asp Ala Leu Phe Asp Lys Asp Arg Pro Gln 
    930                 935                 940                 


Glu Glu Asp Glu Asn His Leu Tyr Thr Cys Gln Asn Ile Lys Lys Ser 
945                 950                 955                 960 


<210>  2852
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2852

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys Arg Gly Asn Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Lys Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Ala Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu 
    290                 295                 300                 


Tyr Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Val Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2853
<211>  960
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2853

Met Ala Lys Lys Leu Asn Ala Lys Glu Lys Arg Leu Leu Ser Gln Gln 
1               5                   10                  15      


Ala Gln Lys Asp Lys Tyr Lys Lys Met Glu Glu Glu Arg Gln Ala Ala 
            20                  25                  30          


Glu Gln Ala Arg Leu Ala Glu Glu Ala Arg Gln Lys Ala Glu Thr Glu 
        35                  40                  45              


Arg Lys Lys Lys Glu Ala Leu Glu Lys Glu Ala Arg Glu Lys Leu Glu 
    50                  55                  60                  


Lys Glu Leu Leu Glu Lys Asn Pro Ser Leu Lys Lys Val Lys Lys Ser 
65                  70                  75                  80  


Lys Ala Lys Ala Ala Gly Leu Lys Ser Thr Phe Ala Ile Gly Asn Glu 
                85                  90                  95      


Leu Leu Met Thr Ser Phe Gly Lys Gly Asn Glu Ala Val Pro Glu His 
            100                 105                 110         


Tyr Ile Phe Glu Asn Gly Met Ile Ser Met Gln Asn Pro Pro Ala Phe 
        115                 120                 125             


Asp Val Glu Asn Arg Gly Thr Ser Phe Ser Ile Ala Gly Lys Asn Ala 
    130                 135                 140                 


Met Asn Ala Ile Ala Asp Asp Pro Arg Arg Thr Ser Lys Lys Val Ile 
145                 150                 155                 160 


Gly Glu Asp Leu Ile Gly Ala Lys Ser Ala Leu Glu Lys Arg Tyr Phe 
                165                 170                 175     


Gly Lys Thr Phe Glu Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
            180                 185                 190         


Leu Asp Ile Glu Lys Ile Leu Ser Lys His Ile Asn Asn Ile Val Phe 
        195                 200                 205             


Ser Ile Asn Asn Ile Arg Gly Ile Ala Asp Pro Glu Arg Asp Asp Leu 
    210                 215                 220                 


Ile Gly Tyr Met Ser Leu Arg Asp Ser Tyr Glu Tyr Phe Met Asp Glu 
225                 230                 235                 240 


Lys Asn Glu Lys Arg Lys Val Leu Arg Glu Ser Tyr Arg Lys Leu Phe 
                245                 250                 255     


Lys Ser Ser Arg Leu Ser Tyr Phe Gly Ser Ala Phe Tyr Val Glu Lys 
            260                 265                 270         


Gln Ser Thr Gln Lys Lys Lys Ser Gly Gln Lys Asn Phe Glu Leu Arg 
        275                 280                 285             


Asn Glu Lys Asp Cys Tyr Tyr Met Leu Ala Leu Leu Gly Glu Leu Arg 
    290                 295                 300                 


Gln Val Leu Ala His Ser Ser Ala Gln Lys Gln Gly Lys Glu Gln Thr 
305                 310                 315                 320 


Glu Ala Arg Ser Ser Val Tyr Asn Leu Arg Thr Val Gly Asn Asn Asp 
                325                 330                 335     


Met Arg Lys Ile Leu Asn Ser Leu Tyr Ala Glu Arg Val Asp Ala Leu 
            340                 345                 350         


Asn Glu Asn Phe Met Asn Tyr Ala Lys Lys Asp Leu Thr Ile Leu Phe 
        355                 360                 365             


Gly Ile Met Asp Ala Ser Ser Tyr Glu Lys Lys Ala Glu Ile Ala Arg 
    370                 375                 380                 


Asp Phe Tyr Asp Phe Thr Val Arg Lys Ser Tyr Lys Asn Ile Gly Phe 
385                 390                 395                 400 


Ser Ile Lys Lys Ile Arg Glu Arg Met Met Asp Cys Phe Phe Ala Asn 
                405                 410                 415     


Val Lys Glu Ile Thr Pro Asp Ser Pro Asp Phe Gln Ser Val Arg Gln 
            420                 425                 430         


Lys Phe Tyr Lys Ile Leu Asp Phe Leu Leu Phe Thr Tyr Tyr Lys Asp 
        435                 440                 445             


Asn Lys Glu Glu Thr Lys Lys Ile Ile Ala Ala Leu Arg Ala Ser Leu 
    450                 455                 460                 


Thr Glu Leu Glu Lys Glu Leu Phe Tyr Gln Lys Gln Ala Asn Ile Leu 
465                 470                 475                 480 


Trp Asn Lys Met Gln Met Val Val Thr Glu Gln Ile Tyr Pro Arg Thr 
                485                 490                 495     


Lys Gly Ser Ala Ile Gln Asn Leu Ile Ala Asp Pro Glu Ile Ser Ala 
            500                 505                 510         


Asp Met Leu Lys Gly Val Met Ile Thr Pro Glu Ser Val Asp Tyr Phe 
        515                 520                 525             


Ser Lys Met Ile Tyr Leu Leu Thr Leu Phe Ile Asp Gly Lys Glu Ile 
    530                 535                 540                 


Asn Asp Leu Leu Thr Thr Met Ile Asn Lys Phe Glu Asn Ile Ala Ser 
545                 550                 555                 560 


Phe Val Ser Val Leu Lys Asp Arg Gly Leu Pro Cys Asn Phe Arg Asn 
                565                 570                 575     


Asp Tyr Ser Val Phe Asn Asn Ala Leu Lys Ile Ser Ala Glu Leu Arg 
            580                 585                 590         


Glu Ile Asn Ser Phe Ala Arg Met Glu Lys Ala Thr Pro Gly Ala Lys 
        595                 600                 605             


Lys Gln Met Phe Leu Asp Ala Ala Ile Ile Leu Gly Ser Asn Glu Ser 
    610                 615                 620                 


Ala Glu Glu Leu Ser Glu Tyr Phe Asp Glu Met Leu Asp Lys Gln Lys 
625                 630                 635                 640 


Gly Lys Arg Thr Pro Gly Gly Lys Lys Asp Met Gly Phe Arg Asn Phe 
                645                 650                 655     


Leu Ile Lys Asn Val Ile Glu Ser Asp Arg Phe His Tyr Leu Ile Arg 
            660                 665                 670         


Tyr Gly His Pro Leu His Ile Arg Lys Leu Ala Glu Asn Lys Asn Val 
        675                 680                 685             


Ile Ala Phe Val Leu Lys Gln Ile Pro Glu Pro Gln Ile Asp Arg Tyr 
    690                 695                 700                 


Cys Lys Ile Cys Ala Leu Pro Ala Glu Ser Asn Phe Ala Gln Lys Ile 
705                 710                 715                 720 


Leu Arg Leu Thr Asp Leu Ile Ala Glu Met Asn Phe Arg Gln Phe Glu 
                725                 730                 735     


Asn Val Arg Gln Thr Glu Lys Asn Glu Gln Lys Gln Ile Leu Gln Gly 
            740                 745                 750         


Ile Leu Ser Leu Tyr Leu Thr Val Leu Tyr Leu Leu Thr Lys Asn Leu 
        755                 760                 765             


Val Tyr Val Asn Ser Arg Tyr Phe Leu Ala Phe His Cys Leu Glu Arg 
    770                 775                 780                 


Asp Thr Glu Leu Leu Gly Ser Gln Ala Gly His Lys Asn Ala Glu Lys 
785                 790                 795                 800 


Gln Leu Ile Ala Ser Tyr Ser Ala Leu Thr Gln Gln Phe Leu Asp Glu 
                805                 810                 815     


Gly Lys Leu Asn Arg His Ala Arg Glu Tyr Leu Thr Val Asn Ile Gln 
            820                 825                 830         


Asn Ser Asp Asp Trp Thr Ile Ala Gln Tyr Arg Asn Asn Ala Ala His 
        835                 840                 845             


Leu Asn Ala Ile Arg Asn Ala His Leu Tyr Ile Arg Glu Met Lys Ser 
    850                 855                 860                 


Val Arg Ser Tyr Phe Glu Leu Tyr His Tyr Leu Thr Gln Arg Ala Leu 
865                 870                 875                 880 


Leu Asp Lys Tyr Glu Asn Val Pro Tyr His Pro Gln Val Asn Glu Lys 
                885                 890                 895     


Thr Leu Lys Tyr Phe Glu Leu Leu Lys Glu Asn Gly Trp Tyr Cys Lys 
            900                 905                 910         


Asp Phe Val Lys Ala Leu Asn Val Pro Phe Gly Tyr Asn Leu Pro Arg 
        915                 920                 925             


Tyr Lys Asn Leu Ser Ile Asp Ala Leu Phe Asp Lys Asp Arg Pro Gln 
    930                 935                 940                 


Glu Glu Asp Glu Asn His Leu Tyr Thr Cys Gln Asn Ile Lys Lys Ser 
945                 950                 955                 960 


<210>  2854
<211>  1023
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2854

Met Gly Glu Glu Lys Lys Asp Ser Tyr Gly Thr Lys Lys Lys Ser Trp 
1               5                   10                  15      


Pro Lys Cys Tyr Gly Leu Lys Ser Val Leu Asp Tyr Gln Gly His Ile 
            20                  25                  30          


Val Val Thr Ser Val Ala Lys Glu Ala Asp Thr Ala Lys Asn Glu Thr 
        35                  40                  45              


Gly Gly Phe Asp Gln Glu Thr Gln Pro Asp Cys Thr Leu Ile Arg Gly 
    50                  55                  60                  


Val Asp Asp Met Glu Phe Ser Leu Ala Asp Gly Glu Lys Lys Ile Lys 
65                  70                  75                  80  


Val Lys Ala Lys Asp Ala Lys Gln Asp Phe Leu Val Glu Lys Pro Phe 
                85                  90                  95      


Ser Tyr Ala Lys Thr Glu Asp Gly Ala Pro Lys Leu Ser Pro Lys Glu 
            100                 105                 110         


Asp Tyr Leu Gly Ile Ala Lys Tyr Ile Cys His Asp Ile Phe Gly Gln 
        115                 120                 125             


Pro Leu Glu Glu Arg Tyr Asp Asp Asn Ile His Tyr Gln Ile Ala Tyr 
    130                 135                 140                 


Asn Ile Ala Asp Leu Glu Lys Ile Ile Phe Tyr Glu Val Asn Asp Ala 
145                 150                 155                 160 


Cys Phe Ala Val Asp Asn Ile Leu Lys Ala Lys Asp Phe Asp Glu Ala 
                165                 170                 175     


Ala Ser Leu Arg Pro Ile Asp Arg Ser Thr Leu Ser Lys Glu Glu Val 
            180                 185                 190         


Lys Arg Ala Glu Met Glu Arg Asp Phe Ile Gly Glu Phe Asn Pro Lys 
        195                 200                 205             


Pro Thr Phe Asn Glu Glu Val Ala Phe Ala Ala Ser Lys Pro Thr Asp 
    210                 215                 220                 


Glu Asp Gly Lys Ala Lys Val Met Ala Ala Asn Val Gln Leu Asp Thr 
225                 230                 235                 240 


Phe Ala Arg Phe Asn Arg Leu Ala Glu Pro Tyr Ser Pro Phe Phe Asn 
                245                 250                 255     


Ser Leu Phe Ile Tyr Arg Asp Lys Lys Ile Glu Ser Arg Lys Gln Pro 
            260                 265                 270         


Gly Asp Asp Tyr Phe Ala Glu His Asn Tyr Asn Val Ile Arg Val Leu 
        275                 280                 285             


Ala Ser Leu Arg His Phe Phe Thr His Arg Thr Trp Gly Lys Ala Asp 
    290                 295                 300                 


Val Ala Asp Gly Glu Ala Ser Asp Thr Ser Phe Phe Asp Phe Ser His 
305                 310                 315                 320 


Glu Leu Val Asn Lys Tyr Lys Gly Val Ala Asp Phe Ala Ser Met Thr 
                325                 330                 335     


Phe Ala Asn Lys Ala Asn Glu Leu Asn Glu Ser Phe Ala Asn Thr Cys 
            340                 345                 350         


Ala Thr Asp Leu Val Ile Leu Cys Ala Tyr Phe Gly Thr Asp Thr Lys 
        355                 360                 365             


Asp Glu Ala Gly Val Arg Lys His Leu Arg Ser Tyr Tyr Asp Phe Val 
    370                 375                 380                 


Val Gly Glu Ser Ala Lys Asn Ile Gly Ile Asn Met Thr Lys Val Arg 
385                 390                 395                 400 


Glu Lys Met Ile Asp Ala His Tyr Gly Glu Gly Ser Asp Asn Asn Leu 
                405                 410                 415     


Arg Ser Lys Glu His Asp Ser Tyr Arg Gly Arg Leu Tyr Arg Leu Phe 
            420                 425                 430         


Ser Tyr Val Leu Phe Leu Asp Val Glu Ser Asp Pro Thr Lys Phe Val 
        435                 440                 445             


Asp Pro Asn Val Ala Lys Leu Arg Leu Ala Arg Thr Asp Glu Asp Lys 
    450                 455                 460                 


Gly Ala Ile Tyr Ala Gln Met Ala Glu Asp Cys Phe Gln Ala Phe Lys 
465                 470                 475                 480 


Asp Asp Phe Ser Glu Met Ile Arg Leu Val Arg Glu Asn Val Arg Ile 
                485                 490                 495     


Asn Gly Glu Lys Ser Lys Gln Lys Phe Pro Phe Ala Ile Thr Val Glu 
            500                 505                 510         


Asn Pro Leu Leu Gly Asp Glu Glu Thr Leu Ile Phe Val Gln Met Val 
        515                 520                 525             


Phe Phe Leu Ser Leu Phe Leu Gly Glu Lys Glu Ser Asn Asp Leu Leu 
    530                 535                 540                 


Thr Ser Leu Ser Asn Lys Phe Asp Asn Ile Val Gln Phe Met Lys Val 
545                 550                 555                 560 


Leu Val Phe Leu Asp Pro Glu His Lys Gln Val His Ile Asn Gly Lys 
                565                 570                 575     


Tyr Ser Leu Phe Arg Val Glu Asn Ala Glu Lys Ile Ala Thr Gln Leu 
            580                 585                 590         


Arg Val Ala Gln Lys Val Ser Arg Met Arg Lys Asn Leu Lys Lys Ala 
        595                 600                 605             


Asp Val Ser Ala Ser Leu Leu Gly Glu Ala Met Asn Val Phe Ser Arg 
    610                 615                 620                 


His Asp Phe Tyr Ala Pro Asp Asp Val Gly Ala Asp Gly Lys Val Val 
625                 630                 635                 640 


Arg Asp Pro Arg Leu Ala Lys Met Leu Asp Asp Thr Phe Asn Ser Lys 
                645                 650                 655     


Lys Gly Ser Asp Asp Arg Thr Phe Arg Asn Phe Leu Leu Asn Asn Val 
            660                 665                 670         


Leu Ala Ser Arg Arg Phe Ala Tyr Ile Ile Arg Tyr Phe Asp Ala Arg 
        675                 680                 685             


Gly Val Arg Arg Leu Met Asp Ala Asp Ser Ala Val Arg Phe Val Leu 
    690                 695                 700                 


Gly Thr Ile Pro Glu Thr Gln Ile Arg Arg Tyr Tyr Gly Val Met Ala 
705                 710                 715                 720 


Gln Asn Pro Ala Pro Leu Pro Gln Met Ile Asp Phe Leu Ala Ser Gln 
                725                 730                 735     


Met Lys Leu Leu Asp Ile Asp Phe Leu Leu Gly Lys Lys Gly Ala Met 
            740                 745                 750         


Gln Gln Trp Ala Lys Ser Val Gly Arg Val Pro Ala Asp Lys Gln Val 
        755                 760                 765             


Phe Leu Thr Gln Val Gly Leu Tyr Leu Thr Val Ala Tyr Leu Ile Val 
    770                 775                 780                 


Lys Asn Val Val Asn Ala Asn Ala Arg Phe Ser Ser Ala Phe Ala Ser 
785                 790                 795                 800 


Tyr Glu Cys Asp Arg Ser Leu Tyr Ala Lys Ser Met Gly Glu Lys Ala 
                805                 810                 815     


Val Ser Lys Ala Gly Gly Asp Leu Asn Ser Tyr Asp Ala Asp Leu Thr 
            820                 825                 830         


Arg Phe Phe Ile Gly Gln Leu Pro Gly Lys Asp Ala Asp Gly Asn Asp 
        835                 840                 845             


Ala Leu Val Gly Leu Asn Lys Tyr Tyr Phe Lys Ser Gln Arg Tyr Leu 
    850                 855                 860                 


Leu Asp Tyr Cys Arg Tyr Phe Glu Arg Leu Glu Lys Glu Cys Asn Ile 
865                 870                 875                 880 


Asp Lys Leu Ser Val Gly Lys Leu Tyr Arg Asn His Val Val His Leu 
                885                 890                 895     


Asn Tyr Ile Ala Gly Leu Ala Asn Ile Lys Glu Ile Glu His Val Arg 
            900                 905                 910         


Ser Tyr Tyr Asp Ile Tyr Val Tyr Leu Val Glu Lys Gly Met Val Thr 
        915                 920                 925             


Ser Phe Glu Asp Pro Ala Thr Lys Ala Ile Val Leu Ala Ser Val Pro 
    930                 935                 940                 


Ser Asp Gly Ala Asp Lys Pro Ala Asp Lys Ser Leu Leu Ala Asp Leu 
945                 950                 955                 960 


Lys Phe Ser Leu Asp Lys Tyr His Ser Tyr Ser Trp Met Phe Phe Lys 
                965                 970                 975     


Trp Leu Asn Ala Met Phe Gly Tyr Cys Leu Pro Arg Phe Gln Asn Leu 
            980                 985                 990         


Thr Thr Ala Asn Leu Phe Asn Glu  Arg Asp Tyr Gly Arg  Ser Val Ile 
        995                 1000                 1005             


Lys Arg  Pro Glu Pro Lys Ser  Gln Phe Asp Ala Ala  Lys Ala Lys 
    1010                 1015                 1020             


<210>  2855
<211>  1023
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2855

Met Gly Glu Glu Lys Lys Asp Ser Tyr Gly Thr Lys Lys Lys Ser Trp 
1               5                   10                  15      


Pro Lys Cys Tyr Gly Leu Lys Ser Val Leu Asp Tyr Gln Gly His Ile 
            20                  25                  30          


Val Val Thr Ser Val Ala Lys Glu Ala Asp Thr Ala Lys Asn Glu Thr 
        35                  40                  45              


Gly Gly Phe Asp Gln Glu Thr Gln Pro Asp Cys Thr Leu Ile Arg Gly 
    50                  55                  60                  


Val Asp Asp Met Glu Phe Ser Leu Ala Asp Gly Glu Lys Lys Ile Lys 
65                  70                  75                  80  


Val Lys Ala Lys Asp Ala Lys Gln Asp Phe Leu Val Glu Lys Pro Phe 
                85                  90                  95      


Ser Tyr Ala Lys Thr Glu Asp Gly Ala Pro Lys Leu Ser Pro Lys Glu 
            100                 105                 110         


Asp Tyr Leu Gly Ile Ala Lys Tyr Ile Cys His Asp Ile Phe Gly Gln 
        115                 120                 125             


Pro Leu Glu Glu Arg Tyr Asp Asp Asn Ile His Tyr Gln Ile Ala Tyr 
    130                 135                 140                 


Asn Ile Ala Asp Leu Glu Lys Ile Ile Phe Tyr Glu Val Asn Asp Ala 
145                 150                 155                 160 


Cys Phe Ala Val Asp Asn Ile Leu Lys Ala Lys Asp Phe Asp Glu Ala 
                165                 170                 175     


Ala Ser Leu Arg Pro Ile Asp Arg Ser Thr Leu Ser Lys Glu Glu Val 
            180                 185                 190         


Lys Arg Ala Glu Met Glu Arg Asp Phe Ile Gly Glu Phe Asn Pro Lys 
        195                 200                 205             


Pro Thr Phe Asn Glu Glu Val Ala Phe Ala Ala Ser Lys Pro Thr Asp 
    210                 215                 220                 


Glu Asp Gly Lys Ala Lys Val Met Ala Ala Asn Val Gln Leu Asp Thr 
225                 230                 235                 240 


Phe Ala Arg Phe Asn Arg Leu Ala Glu Pro Tyr Ser Pro Phe Phe Asn 
                245                 250                 255     


Ser Leu Phe Ile Tyr Arg Asp Lys Lys Ile Glu Ser Arg Lys Gln Pro 
            260                 265                 270         


Gly Asp Asp Tyr Phe Ala Glu His Asn Tyr Asn Val Ile Arg Val Leu 
        275                 280                 285             


Ala Ser Leu Arg His Phe Phe Thr His Arg Thr Trp Gly Lys Ala Asp 
    290                 295                 300                 


Val Ala Asp Gly Glu Ala Ser Asp Thr Ser Phe Phe Asp Phe Ser His 
305                 310                 315                 320 


Glu Leu Val Asn Lys Tyr Lys Gly Val Ala Asp Phe Ala Ser Met Thr 
                325                 330                 335     


Phe Ala Asn Lys Ala Asn Glu Leu Asn Glu Ser Phe Ala Asn Thr Cys 
            340                 345                 350         


Ala Thr Asp Leu Val Ile Leu Cys Ala Tyr Phe Gly Thr Asp Thr Lys 
        355                 360                 365             


Asp Glu Ala Gly Val Arg Lys His Leu Arg Ser Tyr Tyr Asp Phe Val 
    370                 375                 380                 


Val Gly Glu Ser Ala Lys Asn Ile Gly Ile Asn Met Thr Lys Val Arg 
385                 390                 395                 400 


Glu Lys Met Ile Asp Ala His Tyr Gly Glu Gly Ser Asp Asn Asn Leu 
                405                 410                 415     


Arg Ser Lys Glu His Asp Ser Tyr Arg Gly Arg Leu Tyr Arg Leu Phe 
            420                 425                 430         


Ser Tyr Val Leu Phe Leu Asp Val Glu Ser Asp Pro Thr Lys Phe Val 
        435                 440                 445             


Asp Pro Asn Val Ala Lys Leu Arg Leu Ala Arg Thr Asp Glu Asp Lys 
    450                 455                 460                 


Gly Ala Ile Tyr Ala Gln Met Ala Glu Asp Cys Phe Gln Ala Phe Lys 
465                 470                 475                 480 


Asp Asp Phe Ser Glu Met Ile Arg Leu Val Arg Glu Asn Val Arg Ile 
                485                 490                 495     


Asn Gly Glu Lys Ser Lys Gln Lys Phe Pro Phe Ala Ile Thr Val Glu 
            500                 505                 510         


Asn Pro Leu Leu Gly Asp Glu Glu Thr Leu Ile Phe Val Gln Met Val 
        515                 520                 525             


Phe Phe Leu Ser Leu Phe Leu Gly Glu Lys Glu Ser Asn Asp Leu Leu 
    530                 535                 540                 


Thr Ser Leu Ser Asn Lys Phe Asp Asn Ile Val Gln Phe Met Lys Val 
545                 550                 555                 560 


Leu Val Phe Leu Asp Pro Glu His Lys Gln Val His Ile Asn Gly Lys 
                565                 570                 575     


Tyr Ser Leu Phe Arg Val Glu Asn Ala Glu Lys Ile Ala Thr Gln Leu 
            580                 585                 590         


Arg Val Ala Gln Lys Val Ser Arg Met Arg Lys Asn Leu Lys Lys Ala 
        595                 600                 605             


Asp Val Ser Ala Ser Leu Leu Gly Glu Ala Met Asn Val Phe Ser Arg 
    610                 615                 620                 


His Asp Phe Tyr Ala Pro Asp Asp Val Gly Ala Asp Gly Lys Val Val 
625                 630                 635                 640 


Arg Asp Pro Arg Leu Ala Lys Met Leu Asp Asp Thr Phe Asn Ser Lys 
                645                 650                 655     


Lys Gly Ser Asp Asp Arg Thr Phe Arg Asn Phe Leu Leu Asn Asn Val 
            660                 665                 670         


Leu Ala Ser Arg Arg Phe Ala Tyr Ile Ile Arg Tyr Phe Asp Ala Arg 
        675                 680                 685             


Gly Val Arg Arg Leu Met Asp Ala Asp Ser Ala Val Arg Phe Val Leu 
    690                 695                 700                 


Gly Thr Ile Pro Glu Thr Gln Ile Arg Arg Tyr Tyr Gly Val Met Ala 
705                 710                 715                 720 


Gln Asn Pro Ala Pro Leu Pro Gln Met Ile Asp Phe Leu Ala Ser Gln 
                725                 730                 735     


Met Lys Leu Leu Asp Ile Asp Phe Leu Leu Gly Lys Lys Gly Ala Met 
            740                 745                 750         


Gln Gln Trp Ala Lys Ser Val Gly Arg Val Pro Ala Asp Lys Gln Val 
        755                 760                 765             


Phe Leu Thr Gln Val Gly Leu Tyr Leu Thr Val Ala Tyr Leu Ile Val 
    770                 775                 780                 


Lys Asn Val Val Asn Ala Asn Ala Arg Phe Ser Ser Ala Phe Ala Ser 
785                 790                 795                 800 


Tyr Glu Cys Asp Arg Ser Leu Tyr Ala Lys Ser Met Gly Glu Lys Ala 
                805                 810                 815     


Val Ser Lys Ala Gly Gly Asp Leu Asn Ser Tyr Asp Ala Asp Leu Thr 
            820                 825                 830         


Arg Phe Phe Ile Gly Gln Leu Pro Gly Lys Asp Ala Asp Gly Asn Asp 
        835                 840                 845             


Ala Leu Val Gly Leu Asn Lys Tyr Tyr Phe Lys Ser Gln Arg Tyr Leu 
    850                 855                 860                 


Leu Asp Tyr Cys Arg Tyr Phe Glu Arg Leu Glu Lys Glu Cys Asn Ile 
865                 870                 875                 880 


Asp Lys Leu Ser Val Gly Lys Leu Tyr Arg Asn His Val Val His Leu 
                885                 890                 895     


Asn Tyr Ile Ala Gly Leu Ala Asn Ile Lys Glu Ile Glu His Val Arg 
            900                 905                 910         


Ser Tyr Tyr Asp Ile Tyr Val Tyr Leu Val Glu Lys Gly Met Val Thr 
        915                 920                 925             


Ser Phe Glu Asp Pro Ala Thr Lys Ala Ile Val Leu Ala Ser Val Pro 
    930                 935                 940                 


Ser Asp Gly Ala Asp Lys Pro Ala Asp Lys Ser Leu Leu Ala Asp Leu 
945                 950                 955                 960 


Lys Phe Ser Leu Asp Lys Tyr His Ser Tyr Ser Trp Met Phe Phe Lys 
                965                 970                 975     


Trp Leu Asn Ala Met Phe Gly Tyr Cys Leu Pro Arg Phe Gln Asn Leu 
            980                 985                 990         


Thr Thr Ala Asn Leu Phe Asn Glu  Arg Asp Tyr Gly Arg  Ser Val Ile 
        995                 1000                 1005             


Lys Arg  Pro Glu Pro Lys Ser  Gln Phe Asp Ala Ala  Lys Ala Lys 
    1010                 1015                 1020             


<210>  2856
<211>  923
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2856

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Lys Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Asn Ala Leu Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu His Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Asp Asp Tyr 
            340                 345                 350         


Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys 
        355                 360                 365             


Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met 
    370                 375                 380                 


Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val 
385                 390                 395                 400 


Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr 
                405                 410                 415     


Tyr Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg 
            420                 425                 430         


Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala 
        435                 440                 445             


Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp 
    450                 455                 460                 


His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp 
465                 470                 475                 480 


Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu 
                485                 490                 495     


Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly 
            500                 505                 510         


Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn 
        515                 520                 525             


Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn Val Glu 
    530                 535                 540                 


Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile 
545                 550                 555                 560 


Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro 
                565                 570                 575     


Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu 
            580                 585                 590         


Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys 
        595                 600                 605             


Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr 
    610                 615                 620                 


Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala 
625                 630                 635                 640 


Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met 
                645                 650                 655     


Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys 
            660                 665                 670         


Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg 
        675                 680                 685             


Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys 
    690                 695                 700                 


Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg 
705                 710                 715                 720 


Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val 
                725                 730                 735     


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys 
            740                 745                 750         


Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala 
        755                 760                 765             


Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys 
    770                 775                 780                 


Glu Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys 
785                 790                 795                 800 


Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp 
                805                 810                 815     


Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val 
            820                 825                 830         


Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser 
        835                 840                 845             


Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg 
    850                 855                 860                 


Glu Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu 
865                 870                 875                 880 


Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser 
                885                 890                 895     


Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln 
            900                 905                 910         


Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920             


<210>  2857
<211>  935
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2857

Val Leu Leu Phe Ser Val Ser Leu Glu Lys Lys Asn Leu Ala Gln Trp 
1               5                   10                  15      


Glu Glu Thr Ser Ala Glu Gly Arg Arg Ser Arg Val Lys Ala Val Gly 
            20                  25                  30          


Val Lys Ser Val Phe Val Val Gly Asp Asp Leu Tyr Leu Ala Thr Phe 
        35                  40                  45              


Gly Asn Gly Asn Glu Thr Val Leu Glu Lys Lys Ile Thr Pro Asp Gly 
    50                  55                  60                  


Lys Ile Thr Thr Phe Pro Glu Glu Glu Thr Phe Thr Ala Lys Leu Lys 
65                  70                  75                  80  


Phe Ala Lys Thr Glu Leu Thr Glu Ala Thr Ser Ile Gly Ile Ser Asn 
                85                  90                  95      


Gly Arg Ile Val Leu Pro Glu Ile Ser Val Asp Asn Pro Leu His Thr 
            100                 105                 110         


Thr Met Gln Lys Asn Thr Ile Lys Lys Ser Ala Gly Glu Asp Met Leu 
        115                 120                 125             


Gln Leu Lys Asp Val Leu Glu Asn Arg Tyr Phe Asp Arg Ser Phe Asn 
    130                 135                 140                 


Asn Asp Leu His Ile Arg Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys 
145                 150                 155                 160 


Ile Leu Ala Glu Tyr Thr Thr Asn Ala Val Phe Ala Ile Asp Asn Val 
                165                 170                 175     


Ser Gly Cys Ser Asp Asp Phe Leu Ser Asn Phe Ser Thr Arg Asn Gln 
            180                 185                 190         


Trp Asp Glu Phe Gln Asn Pro Glu Gln His Arg Glu His Phe Gly Asn 
        195                 200                 205             


Lys Asp Asn Val Ile Cys Ser Val Lys Lys Gln Gln Asp Leu Phe Phe 
    210                 215                 220                 


Asn Phe Phe Lys Asn Asn Arg Ile Gly Tyr Phe Gly Lys Ala Phe Phe 
225                 230                 235                 240 


His Ala Glu Ser Glu Arg Lys Ile Val Lys Lys Thr Ala Lys Glu Val 
                245                 250                 255     


Tyr His Ile Leu Thr Leu Ile Gly Ser Leu Arg Gln Trp Ile Thr His 
            260                 265                 270         


Ser Thr Glu Gly Gly Ile Ser Arg Leu Trp Leu Tyr Gln Leu Glu Asp 
        275                 280                 285             


Ala Leu Ser Ser Glu Tyr Gln Glu Thr Met Asn Asn Cys Tyr Asn Ser 
    290                 295                 300                 


Thr Ile Tyr Gly Leu Gln Lys Asp Phe Glu Lys Thr Asn Ala Pro Asn 
305                 310                 315                 320 


Leu Asn Phe Leu Ala Glu Ile Leu Gly Lys Asn Ala Ser Glu Leu Ala 
                325                 330                 335     


Glu Pro Tyr Phe Arg Phe Ile Ile Thr Lys Glu Tyr Lys Asn Leu Gly 
            340                 345                 350         


Phe Ser Ile Lys Thr Leu Arg Glu Met Leu Leu Asp Gln Pro Asp Leu 
        355                 360                 365             


Gln Glu Ile Arg Glu Asn His Asn Val Tyr Asp Ser Ile Arg Ser Lys 
    370                 375                 380                 


Leu Tyr Lys Met Met Asp Phe Val Leu Val Tyr Ala Tyr Ser Asn Glu 
385                 390                 395                 400 


Arg Lys Ser Lys Ala Asp Ala Leu Ala Ser Asn Leu Arg Ser Ala Ile 
                405                 410                 415     


Thr Glu Asp Ala Lys Lys Arg Val Tyr Gln Asn Glu Ala Asp Gln Leu 
            420                 425                 430         


Trp Thr Ser Tyr Gln Glu Leu Phe Lys Arg Ile Arg Gly Phe Lys Gly 
        435                 440                 445             


Ala Gln Val Lys Glu Tyr Ser Ser Gln Asn Met Pro Ile Pro Ile Gln 
    450                 455                 460                 


Lys Gln Ile Gln Asn Ile Leu Lys Pro Ala Glu Gln Val Thr Cys Phe 
465                 470                 475                 480 


Thr Lys Leu Met Tyr Leu Leu Thr Met Phe Leu Asp Gly Lys Glu Ile 
                485                 490                 495     


Asn Asp Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp Asn Ile Ser Ser 
            500                 505                 510         


Leu Leu Lys Thr Met Glu Gln Leu Glu Leu Gln Thr Thr Phe Lys Glu 
        515                 520                 525             


Asp Tyr Thr Phe Phe Gln Gln Ser Ser Cys Leu Cys Glu Glu Ile Thr 
    530                 535                 540                 


Gln Leu Lys Ser Phe Ala Arg Met Gly Asn Pro Ile Ser Asn Leu Lys 
545                 550                 555                 560 


Glu Val Met Met Val Asp Ala Ile Gln Ile Leu Gly Thr Glu Lys Ser 
                565                 570                 575     


Glu Gln Glu Leu Gln Ser Met Ala Cys Phe Phe Phe Arg Asp Lys Asn 
            580                 585                 590         


Gly Lys Lys Leu Asn Ala Gly Glu His Gly Met Arg Asn Phe Ile Gly 
        595                 600                 605             


Asn Asn Val Ile Ser Asn Thr Arg Phe Gln Tyr Leu Ile Arg Tyr Gly 
    610                 615                 620                 


Asn Pro Gln Lys Leu His Thr Leu Ser Gln Asn Glu Thr Val Val Arg 
625                 630                 635                 640 


Phe Val Leu Ser Arg Ile Ala Lys Asn Gln Arg Val Gln Gly Met Asn 
                645                 650                 655     


Gly Lys Asn Gln Ile Asp Arg Tyr Tyr Glu Thr Cys Gly Gly Thr Asn 
            660                 665                 670         


Ser Trp Ser Val Ser Glu Glu Glu Lys Ile Asn Phe Leu Cys Lys Ile 
        675                 680                 685             


Leu Thr Asn Met Ser Tyr Asp Gln Phe Gln Asp Val Lys Gln Ser Asp 
    690                 695                 700                 


Lys Ile Ile Thr Ala Glu Glu Lys Arg Lys Lys Glu Arg Tyr Lys Ala 
705                 710                 715                 720 


Ile Ile Ser Leu Tyr Leu Thr Val Leu Tyr Gln Leu Ile Lys Asn Leu 
                725                 730                 735     


Val Asn Ile Asn Ala Arg Tyr Ile Ile Ala Phe His Cys Leu Glu Arg 
            740                 745                 750         


Asp Ala Ile Leu Tyr Ser Leu Lys Phe Asn Thr Ser Ile Asn Leu Lys 
        755                 760                 765             


Lys Arg Tyr Thr Ala Leu Thr Glu Met Ile Leu Gly Tyr Glu Thr Asp 
    770                 775                 780                 


Glu Lys Ala Arg Arg Lys Asp Thr Arg Thr Ile Tyr Glu Lys Ala Glu 
785                 790                 795                 800 


Ala Ala Lys Asn Arg His Leu Lys Asn Val Lys Trp Asn Cys Lys Thr 
                805                 810                 815     


Arg Glu Asn Leu Glu Asn Ala Asp Lys Asn Ala Ile Val Ala Phe Arg 
            820                 825                 830         


Asn Ile Val Ala His Leu Trp Ile Ile Arg Asp Ala Asp Arg Phe Ile 
        835                 840                 845             


Thr Glu Met Gly Ala Met Lys Arg Tyr Phe Asp Cys Tyr His Tyr Leu 
    850                 855                 860                 


Leu Gln Arg Glu Leu Glu Tyr Ile Leu Glu Lys Ser Asn Gln Gly Ser 
865                 870                 875                 880 


Lys Tyr Thr Lys Lys Ser Leu Glu Lys Val Gln Gln Tyr His Ser Tyr 
                885                 890                 895     


Cys Lys Asp Phe Leu His Met Leu Cys Leu Pro Phe Ala Tyr Cys Ile 
            900                 905                 910         


Pro Arg Tyr Lys Asn Leu Ser Ile Ala Glu Leu Phe Asp Arg His Glu 
        915                 920                 925             


Leu Glu Ala Glu Pro Lys Glu 
    930                 935 


<210>  2858
<211>  954
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2858

Met Gly Lys Lys Ile His Ala Arg Asp Leu Arg Glu Gln Arg Lys Thr 
1               5                   10                  15      


Asp Arg Thr Val Lys Phe Ala Asp Gln Asn Glu Lys Arg Glu Ala Gln 
            20                  25                  30          


Arg Ala Val Gln Lys Lys Asp Ala Ala Val Ser Val Lys Ser Val Ser 
        35                  40                  45              


Ser Val Ser Ser Lys Lys Asp Asn Val Thr Lys Ser Met Ala Lys Ala 
    50                  55                  60                  


Ala Gly Val Lys Ser Val Phe Ala Val Glu Asn Thr Val Tyr Met Thr 
65                  70                  75                  80  


Ser Phe Gly Arg Gly Asn Asp Ala Val Leu Glu Gln Lys Ile Val Asp 
                85                  90                  95      


Thr Ser His Glu Pro Leu Asn Ile Asp Asp Pro Ala Tyr Gln Leu Asn 
            100                 105                 110         


Val Val Thr Met Asn Gly Tyr Ser Val Thr Gly His Arg Gly Glu Thr 
        115                 120                 125             


Val Ser Ala Val Thr Asp Asn Pro Leu Arg Arg Phe Asn Gly Gly Lys 
    130                 135                 140                 


Lys Asp Glu Pro Glu Gln Ser Val Pro Thr Asp Met Leu Cys Leu Lys 
145                 150                 155                 160 


Pro Thr Leu Glu Lys Lys Phe Phe Gly Lys Glu Phe Asn Asp Asn Ile 
                165                 170                 175     


His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala 
            180                 185                 190         


Val Tyr Ser Thr Asn Ala Ile Tyr Ala Leu Asn Asn Met Ser Ala Asp 
        195                 200                 205             


Glu Asn Ile Glu Asn Ser Asp Phe Phe Met Lys Arg Thr Thr Asp Glu 
    210                 215                 220                 


Thr Phe Asp Asp Phe Glu Lys Lys Lys Glu Ser Thr Asn Ser Arg Glu 
225                 230                 235                 240 


Lys Ala Asp Phe Asp Ala Phe Glu Lys Phe Ile Gly Asn Tyr Arg Leu 
                245                 250                 255     


Ala Tyr Phe Ala Asp Ala Phe Tyr Val Asn Lys Lys Asn Pro Lys Gly 
            260                 265                 270         


Lys Ala Arg Asn Val Leu Arg Glu Asp Lys Glu Leu Tyr Ser Val Leu 
        275                 280                 285             


Thr Leu Ile Gly Lys Leu Arg His Trp Cys Val His Ser Glu Asp Gly 
    290                 295                 300                 


Arg Ala Glu Phe Trp Leu Tyr Lys Leu Asn Glu Leu Lys Asp Asp Phe 
305                 310                 315                 320 


Lys Asn Val Leu Asp Val Val Tyr Asn Arg Pro Val Glu Glu Ile Asn 
                325                 330                 335     


Asn Arg Phe Ile Glu Asn Asn Lys Val Asn Ile Gln Ile Leu Gly Ser 
            340                 345                 350         


Val Tyr Lys Asn Thr Asp Ile Ala Glu Leu Val Arg Ser Tyr Tyr Glu 
        355                 360                 365             


Phe Leu Ile Thr Lys Lys Tyr Lys Asn Met Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Ser Met Phe Glu Gly Lys Gly Tyr Ala Asp Lys Glu Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Asn Lys Leu Tyr Gln Met Thr Asp Phe Ile Leu Tyr 
                405                 410                 415     


Thr Gly Tyr Ile Asn Glu Asp Ser Asp Arg Ala Asp Asp Leu Val Asn 
            420                 425                 430         


Thr Leu Arg Ser Ser Leu Lys Glu Asp Asp Lys Thr Thr Val Tyr Cys 
        435                 440                 445             


Lys Glu Ala Asp Tyr Leu Trp Lys Lys Tyr Arg Glu Ser Ile Arg Glu 
    450                 455                 460                 


Val Ala Asp Ala Leu Asp Gly Asp Asn Ile Lys Lys Leu Ser Lys Ser 
465                 470                 475                 480 


Asn Ile Glu Ile Gln Glu Asp Lys Leu Arg Lys Cys Phe Ile Ser Tyr 
                485                 490                 495     


Ala Asp Ser Val Ser Glu Phe Thr Lys Leu Ile Tyr Leu Leu Thr Arg 
            500                 505                 510         


Phe Leu Ser Gly Lys Glu Ile Asn Asp Leu Val Thr Thr Leu Ile Asn 
        515                 520                 525             


Lys Phe Asp Asn Ile Arg Ser Phe Leu Glu Ile Met Asp Glu Leu Gly 
    530                 535                 540                 


Leu Asp Arg Thr Phe Thr Ala Glu Tyr Ser Phe Phe Glu Gly Ser Thr 
545                 550                 555                 560 


Lys Tyr Leu Ala Glu Leu Ile Glu Leu Asn Ser Phe Val Lys Ser Cys 
                565                 570                 575     


Ser Phe Asp Ile Asn Ala Lys Arg Thr Met Tyr Arg Asp Ala Leu Asp 
            580                 585                 590         


Ile Leu Gly Ile Glu Ser Gly Lys Thr Glu Glu Asp Ile Glu Lys Met 
        595                 600                 605             


Ile Asp Asn Ile Leu Gln Ile Asp Ala Asn Gly Asp Lys Lys Leu Lys 
    610                 615                 620                 


Lys Asn Asn Gly Leu Arg Asn Phe Ile Ala Ser Asn Val Ile Asp Ser 
625                 630                 635                 640 


Asn Arg Phe Lys Tyr Leu Val Arg Tyr Gly Asn Pro Lys Lys Ile Arg 
                645                 650                 655     


Glu Thr Ala Lys Cys Glu Pro Ala Val Arg Phe Val Leu Asn Glu Ile 
            660                 665                 670         


Pro Asp Ala Gln Ile Glu Arg Tyr Tyr Glu Ala Cys Cys Pro Lys Asn 
        675                 680                 685             


Thr Ala Leu Cys Ser Ala Asn Lys Arg Arg Glu Lys Leu Ala Asp Met 
    690                 695                 700                 


Ile Ala Glu Ile Glu Phe Glu Asn Phe Ser Asp Ala Gly Asn Tyr Gln 
705                 710                 715                 720 


Lys Ala Asn Val Thr Ser Arg Thr His Glu Ala Glu Ile Lys Arg Lys 
                725                 730                 735     


Asn Gln Ala Ile Ile Arg Leu Tyr Leu Thr Val Met Tyr Ile Met Leu 
            740                 745                 750         


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Phe His Cys 
        755                 760                 765             


Val Glu Arg Asp Thr Lys Leu Tyr Ala Glu Ser Gly Leu Glu Val Gly 
    770                 775                 780                 


Asn Ile Glu Lys Asn Lys Thr Asn Leu Thr Met Ala Val Met Gly Val 
785                 790                 795                 800 


Lys Leu Glu Asn Gly Ile Ile Lys Thr Glu Phe Asp Lys Ser Leu Ala 
                805                 810                 815     


Glu Asn Ala Ala Asn Arg Tyr Leu Arg Asn Ala Arg Trp Tyr Lys Leu 
            820                 825                 830         


Ile Leu Asp Asn Leu Lys Lys Ser Glu Arg Ala Val Val Asn Glu Phe 
        835                 840                 845             


Arg Asn Thr Val Cys His Leu Asn Ala Ile Arg Asn Ile Asn Ile Asn 
    850                 855                 860                 


Ile Lys Glu Ile Lys Glu Val Glu Asn Tyr Phe Ala Leu Tyr His Tyr 
865                 870                 875                 880 


Leu Ile Gln Lys His Leu Glu Asn Arg Phe Ala Asp Lys Lys Val Glu 
                885                 890                 895     


Arg Asp Thr Gly Asp Phe Ile Ser Lys Leu Glu Glu His Lys Thr Tyr 
            900                 905                 910         


Cys Lys Asp Phe Val Lys Ala Tyr Cys Thr Pro Phe Gly Tyr Asn Leu 
        915                 920                 925             


Val Arg Tyr Lys Asn Leu Thr Ile Asp Gly Leu Phe Asp Lys Asn Tyr 
    930                 935                 940                 


Pro Gly Lys Asp Asp Ser Asp Glu Gln Lys 
945                 950                 


<210>  2859
<211>  984
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2859

Met Lys Lys Lys Asn Ile Arg Ala Thr Arg Glu Ala Leu Lys Ala Gln 
1               5                   10                  15      


Lys Ile Lys Lys Ser Gln Glu Asn Glu Ala Leu Lys Lys Gln Lys Leu 
            20                  25                  30          


Ala Glu Glu Ala Ala Gln Lys Arg Arg Glu Glu Leu Glu Lys Lys Asn 
        35                  40                  45              


Leu Ala Gln Trp Glu Glu Thr Ser Ala Glu Gly Arg Arg Ser Arg Val 
    50                  55                  60                  


Lys Ala Val Gly Val Lys Ser Val Phe Val Val Gly Asp Asp Leu Tyr 
65                  70                  75                  80  


Leu Ala Thr Phe Gly Asn Gly Asn Glu Thr Val Leu Glu Lys Lys Ile 
                85                  90                  95      


Thr Pro Asp Gly Lys Ile Thr Thr Phe Pro Glu Glu Glu Thr Phe Thr 
            100                 105                 110         


Ala Lys Leu Lys Phe Ala Lys Thr Glu Leu Thr Glu Ala Thr Ser Ile 
        115                 120                 125             


Gly Ile Ser Asn Gly Arg Ile Val Leu Pro Glu Ile Ser Val Asp Asn 
    130                 135                 140                 


Pro Leu His Thr Thr Met Gln Lys Asn Thr Ile Lys Lys Ser Ala Gly 
145                 150                 155                 160 


Glu Asp Met Leu Gln Leu Lys Asp Val Leu Glu Asn Arg Tyr Phe Asp 
                165                 170                 175     


Arg Ser Phe Asn Asn Asp Leu His Ile Arg Leu Ile Tyr Asn Ile Leu 
            180                 185                 190         


Asp Ile Glu Lys Ile Leu Ala Glu Tyr Thr Thr Asn Ala Val Phe Ala 
        195                 200                 205             


Ile Asp Asn Val Ser Gly Cys Ser Asp Asp Phe Leu Ser Asn Phe Ser 
    210                 215                 220                 


Thr Arg Asn Gln Trp Asp Glu Phe Gln Asn Pro Glu Gln His Arg Glu 
225                 230                 235                 240 


His Phe Gly Asn Lys Asp Asn Val Ile Cys Ser Val Lys Lys Gln Gln 
                245                 250                 255     


Asp Leu Phe Phe Asn Phe Phe Lys Asn Asn Arg Ile Gly Tyr Phe Gly 
            260                 265                 270         


Lys Ala Phe Phe His Ala Glu Ser Glu Arg Lys Ile Val Lys Lys Thr 
        275                 280                 285             


Ala Lys Glu Val Tyr His Ile Leu Thr Leu Ile Gly Ser Leu Arg Gln 
    290                 295                 300                 


Trp Ile Thr His Ser Thr Glu Gly Gly Ile Ser Arg Leu Trp Leu Tyr 
305                 310                 315                 320 


Gln Leu Glu Asp Ala Leu Ser Ser Glu Tyr Gln Glu Thr Met Asn Asn 
                325                 330                 335     


Cys Tyr Asn Ser Thr Ile Tyr Gly Leu Gln Lys Asp Phe Glu Lys Thr 
            340                 345                 350         


Asn Ala Pro Asn Leu Asn Phe Leu Ala Glu Ile Leu Gly Lys Asn Ala 
        355                 360                 365             


Ser Glu Leu Ala Glu Pro Tyr Phe Arg Phe Ile Ile Thr Lys Glu Tyr 
    370                 375                 380                 


Lys Asn Leu Gly Phe Ser Ile Lys Thr Leu Arg Glu Met Leu Leu Asp 
385                 390                 395                 400 


Gln Pro Asp Leu Gln Glu Ile Arg Glu Asn His Asn Val Tyr Asp Ser 
                405                 410                 415     


Ile Arg Ser Lys Leu Tyr Lys Met Met Asp Phe Val Leu Val Tyr Ala 
            420                 425                 430         


Tyr Ser Asn Glu Arg Lys Ser Lys Ala Asp Ala Leu Ala Ser Asn Leu 
        435                 440                 445             


Arg Ser Ala Ile Thr Glu Asp Ala Lys Lys Arg Val Tyr Gln Asn Glu 
    450                 455                 460                 


Ala Asp Gln Leu Trp Thr Ser Tyr Gln Glu Leu Phe Lys Arg Ile Arg 
465                 470                 475                 480 


Gly Phe Lys Gly Ala Gln Val Lys Glu Tyr Ser Ser Gln Asn Met Pro 
                485                 490                 495     


Ile Pro Ile Gln Lys Gln Ile Gln Asn Ile Leu Lys Pro Ala Glu Gln 
            500                 505                 510         


Val Thr Cys Phe Thr Lys Leu Met Tyr Leu Leu Thr Met Phe Leu Asp 
        515                 520                 525             


Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp 
    530                 535                 540                 


Asn Ile Ser Ser Leu Leu Lys Thr Met Glu Gln Leu Glu Leu Gln Thr 
545                 550                 555                 560 


Thr Phe Lys Glu Asp Tyr Thr Phe Phe Gln Gln Ser Ser Cys Leu Cys 
                565                 570                 575     


Glu Glu Ile Thr Gln Leu Lys Ser Phe Ala Arg Met Gly Asn Pro Ile 
            580                 585                 590         


Ser Asn Leu Lys Glu Val Met Met Val Asp Ala Ile Gln Ile Leu Gly 
        595                 600                 605             


Thr Glu Lys Ser Glu Gln Glu Leu Gln Ser Met Ala Cys Phe Phe Phe 
    610                 615                 620                 


Arg Asp Lys Asn Gly Lys Lys Leu Asn Ala Gly Glu His Gly Met Arg 
625                 630                 635                 640 


Asn Phe Ile Gly Asn Asn Val Ile Ser Asn Thr Arg Phe Gln Tyr Leu 
                645                 650                 655     


Ile Arg Tyr Gly Asn Pro Gln Lys Leu His Thr Leu Ser Gln Asn Glu 
            660                 665                 670         


Thr Val Val Arg Phe Val Leu Ser Arg Ile Ala Lys Asn Gln Arg Val 
        675                 680                 685             


Gln Gly Met Asn Gly Lys Asn Gln Ile Asp Arg Tyr Tyr Glu Thr Cys 
    690                 695                 700                 


Gly Gly Thr Asn Ser Trp Ser Val Ser Glu Glu Glu Lys Ile Asn Phe 
705                 710                 715                 720 


Leu Cys Lys Ile Leu Thr Asn Met Ser Tyr Asp Gln Phe Gln Asp Val 
                725                 730                 735     


Lys Gln Ser Asp Lys Ile Ile Thr Ala Glu Glu Lys Arg Lys Lys Glu 
            740                 745                 750         


Arg Tyr Lys Ala Ile Ile Ser Leu Tyr Leu Thr Val Leu Tyr Gln Leu 
        755                 760                 765             


Ile Lys Asn Leu Val Asn Ile Asn Ala Arg Tyr Ile Ile Ala Phe His 
    770                 775                 780                 


Cys Leu Glu Arg Asp Ala Ile Leu Tyr Ser Leu Lys Phe Asn Thr Ser 
785                 790                 795                 800 


Ile Asn Leu Lys Lys Arg Tyr Thr Ala Leu Thr Glu Met Ile Leu Gly 
                805                 810                 815     


Tyr Glu Thr Asp Glu Lys Ala Arg Arg Lys Asp Thr Arg Thr Ile Tyr 
            820                 825                 830         


Glu Lys Ala Glu Ala Ala Lys Asn Arg His Leu Lys Asn Val Lys Trp 
        835                 840                 845             


Asn Cys Lys Thr Arg Glu Asn Leu Glu Asn Ala Asp Lys Asn Ala Ile 
    850                 855                 860                 


Val Ala Phe Arg Asn Ile Val Ala His Leu Trp Ile Ile Arg Asp Ala 
865                 870                 875                 880 


Asp Arg Phe Ile Thr Glu Met Gly Ala Met Lys Arg Tyr Phe Asp Cys 
                885                 890                 895     


Tyr His Tyr Leu Leu Gln Arg Glu Leu Glu Tyr Ile Leu Glu Lys Ser 
            900                 905                 910         


Asn Gln Gly Ser Lys Tyr Thr Lys Lys Ser Leu Glu Lys Val Gln Gln 
        915                 920                 925             


Tyr His Ser Tyr Cys Lys Asp Phe Leu His Met Leu Cys Leu Pro Phe 
    930                 935                 940                 


Ala Tyr Cys Ile Pro Arg Tyr Lys Asn Leu Ser Ile Ala Glu Leu Phe 
945                 950                 955                 960 


Asp Arg His Glu Leu Glu Ala Glu Pro Lys Glu Glu Ala Ser Pro Ala 
                965                 970                 975     


Asn Asn Ser Gln Phe Ile Thr Thr 
            980                 


<210>  2860
<211>  921
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2860

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asn Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Asn Arg Val Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Glu 
    370                 375                 380                 


Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Ile Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Gly Glu Ala Ala Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Val Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Asp Arg Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Lys 
785                 790                 795                 800 


Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Asn 
                805                 810                 815     


Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg 
            820                 825                 830         


Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe 
        835                 840                 845             


Ser Ile Tyr His Tyr Val Met Gln Arg Arg Ile Thr Lys Arg Lys Asp 
    850                 855                 860                 


Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys 
865                 870                 875                 880 


Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe 
                885                 890                 895     


Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe 
            900                 905                 910         


Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920     


<210>  2861
<211>  939
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2861

Met Ala Lys Lys Lys Arg Ile Thr Ala Lys Glu Arg Lys Gln Asn His 
1               5                   10                  15      


Arg Glu Leu Leu Met Lys Lys Ala Asp Ser Asn Ala Glu Lys Glu Lys 
            20                  25                  30          


Ala Lys Lys Pro Val Val Glu Asn Lys Pro Asp Thr Ala Ile Ser Lys 
        35                  40                  45              


Asp Asn Thr Pro Lys Pro Asn Lys Glu Ile Lys Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Ala Gly Val Lys Trp Val Ile Lys Ala Asn Asp Asp Val Ala Tyr 
65                  70                  75                  80  


Ile Ser Ser Phe Gly Lys Gly Asn Asn Ser Val Leu Glu Lys Arg Ile 
                85                  90                  95      


Met Gly Asp Val Ser Ser Asn Val Asn Lys Asp Ser His Met Tyr Val 
            100                 105                 110         


Asn Pro Lys Tyr Thr Lys Lys Asn Tyr Glu Ile Lys Asn Gly Phe Ser 
        115                 120                 125             


Ser Gly Ser Ser Leu Val Thr Tyr Pro Asn Lys Pro Asp Lys Asn Ser 
    130                 135                 140                 


Gly Met Asp Ala Leu Cys Leu Lys Pro Tyr Phe Glu Lys Asp Phe Phe 
145                 150                 155                 160 


Gly His Ile Phe Thr Asp Asn Met His Ile Gln Ala Ile Tyr Asn Ile 
                165                 170                 175     


Phe Asp Ile Glu Lys Ile Leu Ala Lys His Ile Thr Asn Ile Ile Tyr 
            180                 185                 190         


Thr Val Asn Ser Phe Asp Arg Asn Tyr Asn Gln Ser Gly Asn Asp Thr 
        195                 200                 205             


Ile Gly Phe Gly Leu Asn Tyr Arg Val Pro Tyr Ser Glu Tyr Gly Gly 
    210                 215                 220                 


Gly Lys Asp Ser Asn Gly Glu Pro Lys Asn Lys Phe Lys Trp Glu Lys 
225                 230                 235                 240 


Arg Asp Asn Phe Ser Lys Phe Tyr Asn Glu Ser Lys Pro His Leu Gly 
                245                 250                 255     


Tyr Tyr Glu Asn Ile Phe Tyr Asp His Gly Glu Pro Ile Ser Glu Glu 
            260                 265                 270         


Lys Phe Tyr Asn Tyr Leu Asn Ile Leu Asn Phe Ile Arg Asn Asn Thr 
        275                 280                 285             


Phe His Tyr Lys Asp Asn Asp Ile Glu Leu Tyr Ser Glu Asn Tyr Ser 
    290                 295                 300                 


Glu Glu Tyr Val Phe Ile Asn Cys Leu Asn Lys Phe Val Lys Asn Lys 
305                 310                 315                 320 


Phe Lys Asn Val Asn Lys Asn Phe Ile Ser Asn Glu Lys Asn Asn Leu 
                325                 330                 335     


Tyr Ile Ile Leu Asn Ala Tyr Gly Lys Asp Thr Glu Asn Val Glu Val 
            340                 345                 350         


Val Lys Lys Tyr Ser Lys Glu Leu Tyr Lys Leu Ser Val Leu Lys Thr 
        355                 360                 365             


Asn Lys Asn Leu Gly Val Asn Val Lys Lys Leu Arg Glu Ser Ala Ile 
    370                 375                 380                 


Glu Tyr Gly Tyr Cys Pro Leu Pro Tyr Asp Lys Glu Lys Glu Val Ala 
385                 390                 395                 400 


Lys Leu Ser Ser Val Lys His Lys Leu Tyr Lys Thr Tyr Asp Phe Val 
                405                 410                 415     


Ile Thr His Tyr Leu Asn Ser Asn Asp Lys Ile Leu Leu Glu Ile Val 
            420                 425                 430         


Glu Ala Leu Arg Leu Ser Lys Asn Asp Asp Glu Lys Glu Asn Val Tyr 
        435                 440                 445             


Lys Lys Tyr Ala Glu Lys Leu Phe Lys Ala Asp Asp Val Ile Asn Pro 
    450                 455                 460                 


Ile Lys Ala Ile Ser Lys Leu Phe Val Glu Lys Gly Asn Lys Leu Phe 
465                 470                 475                 480 


Lys Glu Lys Ile Ile Ile Lys Lys Glu Tyr Ile Glu Asp Val Ser Ile 
                485                 490                 495     


Asp Lys Asn Ile Tyr Asp Phe Thr Lys Val Ile Phe Phe Met Thr Cys 
            500                 505                 510         


Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Asn Ile Ile Ser 
        515                 520                 525             


Lys Leu Gln Ile Ile Glu Asp His Asn Asn Val Ile Lys Phe Ile Ser 
    530                 535                 540                 


His Asn Lys Asp Ala Val Tyr Lys Asp Tyr Ser Asp Lys Tyr Ala Ile 
545                 550                 555                 560 


Phe Arg Asn Ala Gly Lys Ile Ala Thr Glu Leu Glu Ala Ile Lys Ser 
                565                 570                 575     


Ile Ala Arg Met Glu Asn Lys Ile Glu Asn Ala Ser Gln Glu Pro Leu 
            580                 585                 590         


Leu Asn Asp Ala Leu Leu Ser Leu Gly Val Ser Asp Asp Thr Lys Val 
        595                 600                 605             


Leu Glu Asn Thr Tyr Lys Lys Tyr Phe Asp Ser Lys Glu Lys Thr Asp 
    610                 615                 620                 


Lys Gln Ser Gln Lys Val Ser Thr Phe Leu Met Asn Asn Val Ile Asn 
625                 630                 635                 640 


Asn Asn Arg Phe Lys Tyr Val Ile Lys Tyr Ile Asn Pro Ala Asp Ile 
                645                 650                 655     


Asn Gly Leu Ala Lys Asn Arg Tyr Leu Val Lys Phe Val Leu Ser Lys 
            660                 665                 670         


Ile Pro Glu Glu Gln Ile Asp Ser Tyr Tyr Lys Leu Phe Ser Asn Glu 
        675                 680                 685             


Glu Glu Pro Gly Cys Glu Glu Lys Ile Lys Leu Leu Thr Lys Lys Ile 
    690                 695                 700                 


Ser Lys Leu Asn Phe Gln Thr Leu Phe Glu Asn Asn Lys Ile Pro Asn 
705                 710                 715                 720 


Val Glu Lys Glu Lys Lys Lys Ala Ile Ile Thr Leu Tyr Phe Thr Ile 
                725                 730                 735     


Val Tyr Ile Leu Val Lys Asn Leu Val Asn Ile Asn Gly Leu Tyr Thr 
            740                 745                 750         


Leu Ala Leu Tyr Phe Val Glu Arg Asp Gly Tyr Phe Tyr Lys Asp Ile 
        755                 760                 765             


Cys Gly Lys Lys Asp Lys Lys Lys Ser Tyr Asn Asp Val Asp Tyr Leu 
    770                 775                 780                 


Leu Leu Pro Glu Ile Phe Ser Gly Ser Lys Tyr Arg Glu Glu Thr Lys 
785                 790                 795                 800 


Asn Leu Lys Leu Pro Lys Glu Lys Asp Arg Asp Ile Met Lys Lys Tyr 
                805                 810                 815     


Leu Pro Asn Asp Lys Asp Arg Glu Lys Tyr Asn Lys Phe Phe Thr Ala 
            820                 825                 830         


Tyr Arg Asn Asn Ile Val His Leu Asn Ile Ile Ala Lys Leu Ser Glu 
        835                 840                 845             


Leu Thr Lys Asn Ile Asp Lys Asp Ile Asn Ser Tyr Phe Asp Ile Tyr 
    850                 855                 860                 


His Tyr Cys Thr Gln Arg Val Met Phe Asn Tyr Cys Lys Glu Lys Asn 
865                 870                 875                 880 


Asp Val Val Leu Ala Lys Met Lys Asp Leu Ala His Ile Lys Ser Asp 
                885                 890                 895     


Cys Asn Glu Phe Ser Ser Lys His Thr Tyr Pro Phe Ser Ser Ala Val 
            900                 905                 910         


Leu Arg Phe Met Asn Leu Pro Phe Ala Tyr Asn Val Pro Arg Phe Lys 
        915                 920                 925             


Asn Leu Ser Tyr Lys Lys Phe Phe Asp Lys Gln 
    930                 935                 


<210>  2862
<211>  923
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2862

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Val Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Glu Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asn Ser Ser Asn Ile Glu Leu Arg Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Gly Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu His Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Asp Asp Tyr 
            340                 345                 350         


Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys 
        355                 360                 365             


Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met 
    370                 375                 380                 


Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val 
385                 390                 395                 400 


Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr 
                405                 410                 415     


Tyr Arg Asn Asp Val Ile Ala Gly Glu Ala Leu Val Arg Lys Leu Arg 
            420                 425                 430         


Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala 
        435                 440                 445             


Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp 
    450                 455                 460                 


His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp 
465                 470                 475                 480 


Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu 
                485                 490                 495     


Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly 
            500                 505                 510         


Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn 
        515                 520                 525             


Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu 
    530                 535                 540                 


Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile 
545                 550                 555                 560 


Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro 
                565                 570                 575     


Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu 
            580                 585                 590         


Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys 
        595                 600                 605             


Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr 
    610                 615                 620                 


Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala 
625                 630                 635                 640 


Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met 
                645                 650                 655     


Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys 
            660                 665                 670         


Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg 
        675                 680                 685             


Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys 
    690                 695                 700                 


Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg 
705                 710                 715                 720 


Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val 
                725                 730                 735     


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys 
            740                 745                 750         


Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala 
        755                 760                 765             


Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys 
    770                 775                 780                 


Glu Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys 
785                 790                 795                 800 


Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp 
                805                 810                 815     


Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val 
            820                 825                 830         


Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser 
        835                 840                 845             


Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg 
    850                 855                 860                 


Glu Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu 
865                 870                 875                 880 


Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser 
                885                 890                 895     


Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln 
            900                 905                 910         


Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920             


<210>  2863
<211>  900
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2863

Leu Ser Thr Lys Lys Arg Phe Arg Tyr Ser Val Ala Ala Lys Ala Ala 
1               5                   10                  15      


Gly Leu Lys Ser Ser Leu Ala Val Asp Thr Asp Arg Thr Val Met Thr 
            20                  25                  30          


Ser Phe Gly His Gly Asn Ala Ala Ile Leu Glu Lys Glu Ile Val Asp 
        35                  40                  45              


Gly Glu Ile Ser Val Leu Asn Ile Glu Asn Pro Ala Phe Asp Ala Val 
    50                  55                  60                  


Ile Asn Asp Lys Lys Tyr Ala Leu Thr Gly His His Ala Gly Val His 
65                  70                  75                  80  


Ala Leu Val Asp Gln Pro Gln Asn Arg Ser Asp Ala Val His Ile Arg 
                85                  90                  95      


Gly Ala Leu Glu Lys Lys Tyr Phe Gly Asp Thr Phe Ala Asp Asn Ile 
            100                 105                 110         


His Val Gln Ile Ala Tyr Asn Ile Leu Asp Ile Thr Lys Ile Leu Thr 
        115                 120                 125             


Val Tyr Ala Asn Asn Val Val Tyr Ala Leu Asn Asn Leu Val His Ala 
    130                 135                 140                 


Asp Asp Asp Thr Gln Ala Asp Glu Leu Asp Ser Leu Gly Asn Phe Ser 
145                 150                 155                 160 


Ala Gly Thr Ser Tyr Ala Lys Ser Lys Ser Lys Ser Lys Ser Lys Gln 
                165                 170                 175     


Gln Asp Phe Val Glu Leu Phe Ile Lys Lys Lys Glu Ile His Gly Tyr 
            180                 185                 190         


Phe Gly Asp Thr Phe Ala Phe Leu Asp Lys Arg Ile Ala Asp Ala Asp 
        195                 200                 205             


Lys Glu Lys Gln Val Tyr Ala Met Leu Ala Cys Leu Gly Ser Leu Arg 
    210                 215                 220                 


Gln Ala Cys Ser His Tyr Arg Ile Arg Tyr Ser Val Asn Gly Lys Asn 
225                 230                 235                 240 


Val Asp Ala Asp Ala Asp Thr Trp Leu Phe Ser Ser Ala Gln Leu Asp 
                245                 250                 255     


Gln Thr Asp Pro Leu Phe Ser Glu Met Leu Asn Arg Ile Tyr Ser His 
            260                 265                 270         


Lys Ile Lys Thr Val Asn Gln Asn Phe Phe Glu Asn Asn Arg Lys Ala 
        275                 280                 285             


Asn Phe Pro Ile Leu Lys Lys Met Tyr Pro Glu Thr Thr Leu Lys Val 
    290                 295                 300                 


Leu Met Asn Glu Tyr Tyr Asp Phe Ser Ile Arg Lys Gly Tyr Lys Asn 
305                 310                 315                 320 


Phe Gly Phe Ser Ile Lys Ser Leu Arg Glu Ala Leu Leu Ser Pro Gln 
                325                 330                 335     


Tyr Glu Ser Leu Ile Gly Val Gln Ile Lys Asp Asn Lys Glu Tyr Asp 
            340                 345                 350         


Thr Val Arg Ser Lys Leu Tyr Gln Leu Phe Asp Phe Ala Leu Thr Arg 
        355                 360                 365             


Tyr Phe Asn Gln His Pro Asp Met Val Asp Ala Phe Val Val Glu Leu 
    370                 375                 380                 


Arg Ser Leu Ala Lys Asp Glu Asp Ala Lys Asn Ala Val Tyr Glu Lys 
385                 390                 395                 400 


Tyr Ala Lys Ala Val Trp Asn Asp Val Lys Gln Pro Ile Ala Val Met 
                405                 410                 415     


Leu Ser Tyr Met Asn Gly Ser Ala Ile Lys Asn Ile Lys Ala Phe Glu 
            420                 425                 430         


Leu Lys Pro Asp Gln Lys Glu Leu Asn Gly Ile Met Asn Ser Asn Ala 
        435                 440                 445             


Leu Asp Val Pro His Phe Cys Lys Leu Val Tyr Phe Leu Thr Arg Phe 
    450                 455                 460                 


Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Val Asn Lys 
465                 470                 475                 480 


Phe Asp Asn Ile His Ser Phe Asn Gln Val Leu Thr Ala Leu Gly Leu 
                485                 490                 495     


Ser Ala Ser Tyr Glu Ala Asp Tyr Lys Ile Phe Glu Asp Ser Gly Arg 
            500                 505                 510         


Val Val Glu Tyr Leu Arg Glu Ile Asn Ser Phe Ala Arg Met Thr Val 
        515                 520                 525             


Asp Met Glu Lys Ile Lys Arg Ser Ala Tyr Lys Lys Ala Leu Leu Ile 
    530                 535                 540                 


Leu Gly Ser Ser Lys Tyr Ser Asp Glu Asp Leu Asp Ala Arg Val Asp 
545                 550                 555                 560 


Glu Met Leu Gly Val Asp Tyr Asn Gln Asn Gly Glu Lys Ile Lys Val 
                565                 570                 575     


Arg Val Asp Thr Gly Phe Arg Asn Phe Ile Ala Asn Asn Val Val Glu 
            580                 585                 590         


Ser Ser Arg Phe His Tyr Leu Ile Arg Tyr Cys His Pro Arg Lys Ile 
        595                 600                 605             


Arg Asn Leu Ala Gly Asn Ala Ala Leu Ile Glu Tyr Gln Leu Arg Arg 
    610                 615                 620                 


Leu Pro Glu Leu Gln Ile Leu Arg Tyr Tyr Glu Ala Cys Thr Glu Pro 
625                 630                 635                 640 


Ile Lys Arg Thr Ala Arg Thr Met Asp Glu Lys Ile Gly Thr Leu Ile 
                645                 650                 655     


Asp Leu Ile Val Lys Met Asp Phe Ser Gln Phe Glu Asp Val Gln Gln 
            660                 665                 670         


Asn Asp Arg Val Arg Val Phe Ser Asp Ala Glu Lys Lys Glu Lys Ile 
        675                 680                 685             


Arg Lys Met Arg Glu Lys Gln Arg Tyr Gln Ser Ile Ile Ser Leu Tyr 
    690                 695                 700                 


Leu Thr Met Leu Tyr Leu Ile Val Lys Asn Leu Val Asn Ile Asn Ala 
705                 710                 715                 720 


Arg Tyr Val Met Ala Phe Gln Ala Trp Glu Arg Asp Asn Tyr Leu Leu 
                725                 730                 735     


Leu Gln Leu Ser Gly Lys Glu Ala Glu Ala Glu Tyr Leu Asn Leu Thr 
            740                 745                 750         


Arg His Phe Ile Glu Pro Leu Asp Gly Ala Lys Pro Tyr Leu Lys Lys 
        755                 760                 765             


Arg Pro Val Glu Tyr Leu Lys Lys Asp Met Ala Met Val Gly Asn Ser 
    770                 775                 780                 


Ser Ile Arg His Phe Arg Asn Ala Thr Val His Leu Asn Val Ile Met 
785                 790                 795                 800 


Glu Ala His Arg Tyr Thr Lys Asp Ile Lys Tyr Ile Gly Ser Tyr Tyr 
                805                 810                 815     


Ala Leu Tyr His Tyr Ile Leu Gln Arg His Leu Leu Asp Lys Ile Glu 
            820                 825                 830         


Glu Asp Ser Tyr Ala Glu Lys Thr Val Ser Glu Lys Leu Trp Glu Ser 
        835                 840                 845             


Gln Ile Ser Gln Tyr Gly Thr Tyr Ser Lys Asp Phe Val Lys Ala Leu 
    850                 855                 860                 


Cys Cys Pro Phe Gly Tyr Asn Leu Pro Arg Phe Lys Asn Leu Ser Ile 
865                 870                 875                 880 


Glu Gln Leu Phe Asp Arg Asn Glu Ser Lys Glu Ile Thr Asp Ala Thr 
                885                 890                 895     


Ala Pro Arg Gln 
            900 


<210>  2864
<211>  960
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2864

Met Ala Lys Lys Leu Asn Ala Lys Glu Lys Arg Leu Leu Ser Gln Gln 
1               5                   10                  15      


Ala Gln Lys Asp Lys Tyr Lys Lys Met Glu Glu Glu Arg Gln Ala Ala 
            20                  25                  30          


Glu Gln Ala Arg Leu Ala Glu Glu Ala Arg Gln Lys Ala Glu Thr Glu 
        35                  40                  45              


Arg Lys Lys Lys Glu Ala Leu Glu Lys Glu Ala Arg Glu Lys Leu Glu 
    50                  55                  60                  


Lys Glu Leu Leu Glu Lys Asn Pro Ser Leu Lys Lys Val Lys Lys Ser 
65                  70                  75                  80  


Lys Ala Lys Ala Ala Gly Leu Lys Ser Thr Phe Ala Ile Gly Asn Glu 
                85                  90                  95      


Leu Leu Met Thr Ser Phe Gly Lys Gly Asn Glu Ala Val Pro Glu His 
            100                 105                 110         


Tyr Ile Phe Glu Asn Gly Met Ile Ser Met Gln Asn Pro Pro Ala Phe 
        115                 120                 125             


Asp Val Glu Asn Arg Gly Thr Ser Phe Ser Ile Ala Gly Lys Asn Ala 
    130                 135                 140                 


Met Asn Ala Ile Ala Asp Asp Pro Arg Arg Thr Ser Lys Lys Val Ile 
145                 150                 155                 160 


Gly Glu Asp Leu Ile Gly Ala Lys Ser Ala Leu Glu Lys Arg Tyr Phe 
                165                 170                 175     


Gly Lys Thr Phe Glu Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
            180                 185                 190         


Leu Asp Ile Glu Lys Ile Leu Ser Lys His Ile Asn Asn Ile Val Phe 
        195                 200                 205             


Ser Ile Asn Asn Ile Arg Gly Ile Ala Asp Pro Glu Arg Asp Asp Leu 
    210                 215                 220                 


Ile Gly Tyr Met Ser Leu Arg Asp Ser Tyr Glu Tyr Phe Met Asp Glu 
225                 230                 235                 240 


Lys Asn Glu Lys Arg Lys Val Leu Arg Glu Ser Tyr Arg Lys Leu Phe 
                245                 250                 255     


Lys Ser Ser Arg Leu Ser Tyr Phe Gly Ser Ala Phe Tyr Val Glu Lys 
            260                 265                 270         


Gln Ser Thr Gln Lys Lys Lys Ser Gly Gln Lys Asn Phe Glu Leu Arg 
        275                 280                 285             


Asn Glu Lys Asp Cys Tyr Tyr Met Leu Ala Leu Leu Gly Glu Leu Arg 
    290                 295                 300                 


Gln Val Leu Ala His Ser Ser Ala Gln Lys Gln Gly Lys Glu Gln Thr 
305                 310                 315                 320 


Glu Ala Arg Ser Ser Val Tyr Asn Leu Arg Thr Val Gly Asn Asn Asp 
                325                 330                 335     


Met Arg Lys Ile Leu Asn Ser Leu Tyr Ala Glu Arg Val Asp Ala Leu 
            340                 345                 350         


Asn Glu Asn Phe Met Asn Tyr Ala Lys Lys Asp Leu Thr Ile Leu Phe 
        355                 360                 365             


Gly Ile Met Asp Ala Ser Ser Tyr Glu Lys Lys Ala Glu Ile Ala Arg 
    370                 375                 380                 


Asp Phe Tyr Asp Phe Thr Val Arg Lys Ser Tyr Lys Asn Ile Gly Phe 
385                 390                 395                 400 


Ser Ile Lys Lys Ile Arg Glu Arg Met Met Asp Cys Phe Phe Ala Asn 
                405                 410                 415     


Val Lys Glu Ile Thr Pro Asp Ser Pro Asp Phe Gln Ser Val Arg Gln 
            420                 425                 430         


Lys Phe Tyr Lys Ile Leu Asp Phe Leu Leu Phe Thr Tyr Tyr Lys Asp 
        435                 440                 445             


Asn Lys Glu Glu Thr Lys Lys Ile Ile Ala Ala Leu Arg Ala Ser Leu 
    450                 455                 460                 


Thr Glu Leu Glu Lys Glu Leu Phe Tyr Gln Lys Gln Ala Asn Ile Leu 
465                 470                 475                 480 


Trp Asn Lys Met Gln Met Val Val Thr Glu Gln Ile Tyr Pro Arg Thr 
                485                 490                 495     


Lys Gly Ser Ala Ile Gln Asn Leu Ile Ala Asp Pro Glu Ile Ser Ala 
            500                 505                 510         


Asp Met Leu Lys Gly Val Met Ile Thr Pro Glu Ser Val Asp Tyr Phe 
        515                 520                 525             


Ser Lys Met Ile Tyr Leu Leu Thr Leu Phe Ile Asp Gly Lys Glu Ile 
    530                 535                 540                 


Asn Asp Leu Leu Thr Thr Met Ile Asn Lys Phe Glu Asn Ile Ala Ser 
545                 550                 555                 560 


Phe Val Ser Val Leu Lys Asp Arg Gly Leu Pro Cys Asn Phe Arg Asn 
                565                 570                 575     


Asp Tyr Ser Val Phe Asn Asn Ala Leu Lys Ile Ser Ala Glu Leu Arg 
            580                 585                 590         


Glu Ile Asn Ser Phe Ala Arg Met Glu Lys Ala Thr Pro Gly Ala Lys 
        595                 600                 605             


Lys Gln Met Phe Leu Asp Ala Ala Ile Ile Leu Gly Ser Asn Glu Ser 
    610                 615                 620                 


Ala Glu Glu Leu Ser Glu Tyr Phe Asp Glu Met Leu Asp Lys Gln Lys 
625                 630                 635                 640 


Gly Lys Arg Thr Pro Gly Gly Lys Lys Asp Met Gly Phe Arg Asn Phe 
                645                 650                 655     


Leu Ile Lys Asn Val Ile Glu Ser Asp Arg Phe His Tyr Leu Ile Arg 
            660                 665                 670         


Tyr Gly His Pro Leu His Ile Arg Lys Leu Ala Glu Asn Lys Asn Val 
        675                 680                 685             


Ile Ala Phe Val Leu Lys Gln Ile Pro Glu Pro Gln Ile Asp Arg Tyr 
    690                 695                 700                 


Cys Lys Ile Cys Ala Leu Pro Ala Glu Ser Asn Phe Ala Gln Lys Ile 
705                 710                 715                 720 


Leu Arg Leu Thr Asp Leu Ile Ala Glu Met Asn Phe Arg Gln Phe Glu 
                725                 730                 735     


Asn Val Arg Gln Thr Glu Lys Asn Glu Gln Lys Gln Ile Leu Gln Gly 
            740                 745                 750         


Ile Leu Ser Leu Tyr Leu Thr Val Leu Tyr Leu Leu Thr Lys Asn Leu 
        755                 760                 765             


Val Tyr Val Asn Ser Arg Tyr Phe Leu Ala Phe His Cys Leu Glu Arg 
    770                 775                 780                 


Asp Thr Glu Leu Leu Gly Ser Gln Ala Gly His Lys Asn Ala Glu Lys 
785                 790                 795                 800 


Gln Leu Ile Ala Ser Tyr Ser Ala Leu Thr Gln Gln Phe Leu Asp Glu 
                805                 810                 815     


Gly Lys Leu Asn Arg His Ala Arg Glu Tyr Leu Thr Val Asn Ile Gln 
            820                 825                 830         


Asn Ser Asp Asp Trp Thr Ile Ala Gln Tyr Arg Asn Asn Ala Ala His 
        835                 840                 845             


Leu Asn Ala Ile Arg Asn Ala His Leu Tyr Ile Arg Glu Met Lys Ser 
    850                 855                 860                 


Val Arg Ser Tyr Phe Glu Leu Tyr His Tyr Leu Thr Gln Arg Ala Leu 
865                 870                 875                 880 


Leu Asp Lys Tyr Glu Asn Val Pro Tyr His Pro Gln Val Asn Glu Lys 
                885                 890                 895     


Thr Leu Lys Tyr Phe Glu Leu Leu Lys Glu Asn Gly Trp Tyr Cys Lys 
            900                 905                 910         


Asp Phe Val Lys Ala Leu Asn Val Pro Phe Gly Tyr Asn Leu Pro Arg 
        915                 920                 925             


Tyr Lys Asn Leu Ser Ile Asp Ala Leu Phe Asp Lys Asp Arg Pro Gln 
    930                 935                 940                 


Glu Glu Asp Glu Asn His Leu Tyr Thr Cys Gln Asn Ile Lys Lys Ser 
945                 950                 955                 960 


<210>  2865
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2865

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Gly Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asp Tyr Asn 
                85                  90                  95      


Gln Thr Gln Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu Cys Gly 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Lys Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Ala Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe 
                325                 330                 335     


Ile Glu Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Phe Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Glu Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Cys Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Asp Arg Asp Lys Ser Ser Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asp Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asn Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  2866
<211>  946
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2866

Met Lys Lys Phe Ser Asn Ile Lys Arg Leu Gly Val Lys Ser Val His 
1               5                   10                  15      


Tyr Ala Asn Asn Thr Val Ile Val Glu Asp His Phe Ser Lys Asn Thr 
            20                  25                  30          


Asn Ile Leu Phe Thr Ala Glu Tyr Glu Asn Ile Asp Asp Leu Lys Ser 
        35                  40                  45              


Cys Thr Asn Ile Asp Lys Thr Ala Glu Asn Lys Gly Val Arg Phe Thr 
    50                  55                  60                  


Asp Leu Lys Asn Lys Asn Gly Phe Glu Leu Ser Ala Met Ala Gln Lys 
65                  70                  75                  80  


Gln Ile Leu Lys Ser Arg Val Asn Arg Val Lys Lys Val Ser Tyr Thr 
                85                  90                  95      


Gln Glu Leu Phe Asp Ile Thr Thr Asp Asn Asn Ile Glu Val Gln Ile 
            100                 105                 110         


Phe Ser Asn Leu Glu Asp Val Lys Lys Val Ile Ala Pro Tyr Tyr Asn 
        115                 120                 125             


Asn Val Ala Tyr Ala Ile Asn Ser Leu Tyr Arg Asp Ile Ser Asn Asp 
    130                 135                 140                 


Asp Ser Tyr Gly Phe Asp Lys Ile Gly Ser Ile Pro Val Asp Ala Asp 
145                 150                 155                 160 


Trp Tyr Asn Phe Leu Lys Asp Ala Pro Asp Lys Lys Glu Lys Trp Thr 
                165                 170                 175     


Thr Tyr Ile Ile Pro Ser Tyr Lys Lys Val Ile Ala Arg Phe Gly Ile 
            180                 185                 190         


Gln Met Glu Lys Asn Gln Gln Val Asn Phe Cys Lys Cys Leu Glu Tyr 
        195                 200                 205             


Val Ala Ile Arg Asn Gly Leu Phe Val Lys Phe Lys Asp Glu Lys Val 
    210                 215                 220                 


Asp Pro Asp Lys Leu Leu Asn Lys Lys Ile Gln Glu Lys Leu Asp Lys 
225                 230                 235                 240 


Leu Ile Ser Asp Lys Glu Val Asn Asp Lys Leu Phe Glu Leu Ala Lys 
                245                 250                 255     


Thr Pro Val Ser Glu Phe Cys Ala Glu Ala Asn Ala Ile Pro Leu Tyr 
            260                 265                 270         


Arg Tyr Ala Phe Ile Gly Gln Lys Gly Lys Arg Ile Glu Lys Ile Val 
        275                 280                 285             


Leu Asp Lys Leu Glu Glu Asn Glu Ile Leu Ser Ser Leu Val Arg Lys 
    290                 295                 300                 


Ile Asp Glu Asn Glu Thr Thr Tyr Asn Tyr Leu Arg Leu Leu Ser Ala 
305                 310                 315                 320 


Ile Arg Gln Tyr Val Val His Asn Ser Arg Lys Val Arg Ile Asp Lys 
                325                 330                 335     


Asn Val Phe Ile Asn Asp Thr Ala Lys Arg Asp Val Glu Glu Phe Ala 
            340                 345                 350         


Lys Gln Phe Gln Lys Asn Asn Tyr Lys Tyr Phe Cys Ile Leu Lys Glu 
        355                 360                 365             


Leu Tyr Ser Asp Ser Asp Ile Leu Glu Gln Phe Phe Asp Tyr Thr Val 
    370                 375                 380                 


Phe Asp Glu Ala Arg Asn Leu Lys Ile Ser Ile Asp Lys Ile Lys Lys 
385                 390                 395                 400 


Gly Ile Thr Ala Asn Ile Asp Ile Ser Ala Asp Val Glu Pro Asp Lys 
                405                 410                 415     


Leu Ser Glu Tyr Ala Asn Lys Phe Arg Thr Val Thr Met Phe Ala Leu 
            420                 425                 430         


Thr Lys Tyr Leu Lys Glu Asn Val Gly Glu Ile Glu Asp Phe Leu Ala 
        435                 440                 445             


Asn Ile Lys Val Cys Ser Ser Asp Glu Glu Lys Ala Gly Val Tyr Glu 
    450                 455                 460                 


Gln Lys Ala Lys Glu Phe Ile Thr Lys Phe Asp Ser Phe Lys Asp Ile 
465                 470                 475                 480 


Arg Ser Val Val Lys Lys His Leu Gly Thr Gln Lys Val Asn Glu Lys 
                485                 490                 495     


Phe Asp Phe Tyr Pro Ser Asp Ile Asn Phe Gly Arg Asp Ser Asn Val 
            500                 505                 510         


Phe Phe Asn Met Leu Tyr Val Met Ser Lys Phe Leu Thr Val Asn Glu 
        515                 520                 525             


Ala Arg Ile Met Phe Gln Lys Ile Lys Ser Lys Tyr Asp Ser Val Lys 
    530                 535                 540                 


Ser Leu Leu Lys Ile Ala Glu Leu Thr Gly Val Thr Leu Ser Asp Asn 
545                 550                 555                 560 


Leu Phe Asp Arg Phe Arg Met Ile Phe Asp Lys Glu Arg Val Asp Glu 
                565                 570                 575     


Tyr Gln Lys Gln Leu Ile Val Leu Gln Ser Ile Arg Thr Arg Asn Gly 
            580                 585                 590         


Val Ser Gln Glu Gly Phe Ala Lys Glu Leu Lys Arg Ile Phe Asp Met 
        595                 600                 605             


Phe Lys Lys Asp Asp Ile Ser Tyr Glu Glu Phe Glu Lys Glu Leu Ser 
    610                 615                 620                 


Leu Asp Glu Asn Gln Asn Glu Ile Lys Asn Lys Ser Phe Lys Leu Lys 
625                 630                 635                 640 


Pro Leu Lys Ser Tyr Leu Arg Asn Asp Val Tyr Lys Ser Lys Gln Tyr 
                645                 650                 655     


Gln Tyr Ile Ser Ser Phe Ala Ser Ala Gly Ile Cys Gln Lys Ile Met 
            660                 665                 670         


Glu Asn Lys Asp Ile Val Ala Phe Val Leu Asn Gly Met Leu Tyr Gln 
        675                 680                 685             


Glu Gly Lys Leu Ser Met Pro Met His Lys Tyr Val Ala Lys Val Tyr 
    690                 695                 700                 


His Asp Phe Arg Arg Glu Lys Ile Asp Glu Asn Ser Ala Asn Tyr Leu 
705                 710                 715                 720 


Leu Asp Gln Asn Gln Ile Ser Ser Leu Val Asn Ser Leu Cys Asp Leu 
                725                 730                 735     


Lys Leu Glu Asn Ile Ile Glu Ala Ile Phe Lys Glu Ser Arg Val Asn 
            740                 745                 750         


Tyr Lys Ala Leu Val Arg Leu Tyr Leu Asn Ile Cys Tyr Leu Phe Val 
        755                 760                 765             


Lys Asn Ile Ile Ser Leu Asn Ser Thr Tyr Leu Ile Gln Phe Gln Asp 
    770                 775                 780                 


Tyr Glu Asn Ile Tyr Lys Gln Leu His Leu Glu Asp Leu Met Asp Ile 
785                 790                 795                 800 


Thr Tyr Asp Phe Gly Val Leu Asn Asn Phe Val Glu Asn Ala Pro Asn 
                805                 810                 815     


Lys Lys Cys Arg Ser Tyr Met Gln Leu Gln Thr Leu Leu Glu Lys Asp 
            820                 825                 830         


Tyr Ile Lys Asp Tyr Ile Tyr Thr Pro Glu Tyr Gln Val Leu Gln Asp 
        835                 840                 845             


Arg Tyr Arg Asn Leu Val Val His Ser Ser Leu Leu Phe Gly Leu Asp 
    850                 855                 860                 


Lys Ile Asp Phe Asp Phe Gly Glu Val Gln Asn Ile Ser Ser Tyr Phe 
865                 870                 875                 880 


Ala Ile Tyr Gln Thr Leu Val Gln Arg Leu Val Glu Gln Asp Ala Arg 
                885                 890                 895     


Glu Val Trp Gly Glu Lys Phe Asp Glu Tyr Phe Ala Leu Asn Asn Gly 
            900                 905                 910         


Lys Thr Tyr Ser Thr Lys Leu Cys Ile Ala Leu Asn Met Pro Tyr Ala 
        915                 920                 925             


Tyr Asn Ile Ser Arg Phe Asn Asn Asn Thr Ile Glu Lys Tyr Ser Asn 
    930                 935                 940                 


Lys Arg 
945     


<210>  2867
<211>  921
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2867

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Gly Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Asn Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu Tyr Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Val Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp 
    370                 375                 380                 


Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Ile Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Glu Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn Arg 
785                 790                 795                 800 


Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser 
                805                 810                 815     


Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg 
            820                 825                 830         


Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe 
        835                 840                 845             


Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp 
    850                 855                 860                 


Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys 
865                 870                 875                 880 


Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe 
                885                 890                 895     


Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe 
            900                 905                 910         


Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920     


<210>  2868
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2868

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Asn Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Met Lys 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Ile Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Asn Arg Val Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2869
<211>  984
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2869

Met Lys Lys Lys Asn Ile Arg Ala Thr Arg Glu Ala Leu Lys Ala Gln 
1               5                   10                  15      


Lys Ile Lys Lys Ser Gln Glu Asn Glu Ala Leu Lys Lys Gln Lys Leu 
            20                  25                  30          


Ala Glu Glu Ala Ala Gln Lys Arg Arg Glu Glu Leu Glu Lys Lys Asn 
        35                  40                  45              


Leu Ala Gln Trp Glu Glu Thr Ser Ala Glu Gly Arg Arg Ser Arg Val 
    50                  55                  60                  


Lys Ala Val Gly Val Lys Ser Val Phe Val Val Gly Asp Asp Leu Tyr 
65                  70                  75                  80  


Leu Ala Thr Phe Gly Asn Gly Asn Glu Thr Val Leu Glu Lys Lys Ile 
                85                  90                  95      


Thr Pro Asp Gly Lys Ile Thr Thr Phe Pro Glu Glu Glu Thr Phe Thr 
            100                 105                 110         


Ala Lys Leu Lys Phe Ala Lys Thr Glu Leu Thr Glu Ala Thr Ser Ile 
        115                 120                 125             


Gly Ile Ser Asn Gly Arg Ile Val Leu Pro Glu Ile Ser Val Asp Asn 
    130                 135                 140                 


Pro Leu His Thr Thr Met Gln Lys Asn Thr Ile Lys Lys Ser Ala Gly 
145                 150                 155                 160 


Glu Asp Met Leu Gln Leu Lys Asp Val Leu Glu Asn Arg Tyr Phe Asp 
                165                 170                 175     


Arg Ser Phe Asn Asn Asp Leu His Ile Arg Leu Ile Tyr Asn Ile Leu 
            180                 185                 190         


Asp Ile Glu Lys Ile Leu Ala Glu Tyr Thr Thr Asn Ala Val Phe Ala 
        195                 200                 205             


Ile Asp Asn Val Ser Gly Cys Ser Asp Asp Phe Leu Ser Asn Phe Ser 
    210                 215                 220                 


Thr Arg Asn Gln Trp Asp Glu Phe Gln Asn Pro Glu Gln His Arg Glu 
225                 230                 235                 240 


His Phe Gly Asn Lys Asp Asn Val Ile Cys Ser Val Lys Lys Gln Gln 
                245                 250                 255     


Asp Leu Phe Phe Asn Phe Phe Lys Asn Asn Arg Ile Gly Tyr Phe Gly 
            260                 265                 270         


Lys Ala Phe Phe His Ala Glu Ser Glu Arg Lys Ile Val Lys Lys Thr 
        275                 280                 285             


Ala Lys Glu Val Tyr His Ile Leu Thr Leu Ile Gly Ser Leu Arg Gln 
    290                 295                 300                 


Trp Ile Thr His Ser Thr Glu Gly Gly Ile Ser Arg Leu Trp Leu Tyr 
305                 310                 315                 320 


Gln Leu Glu Asp Ala Leu Ser Ser Glu Tyr Gln Glu Thr Met Asn Asn 
                325                 330                 335     


Cys Tyr Asn Ser Thr Ile Tyr Gly Leu Gln Lys Asp Phe Glu Lys Thr 
            340                 345                 350         


Asn Ala Pro Asn Leu Asn Phe Leu Ala Glu Ile Leu Gly Lys Asn Ala 
        355                 360                 365             


Ser Glu Leu Ala Glu Pro Tyr Phe Arg Phe Ile Ile Thr Lys Glu Tyr 
    370                 375                 380                 


Lys Asn Leu Gly Phe Ser Ile Lys Thr Leu Arg Glu Met Leu Leu Asp 
385                 390                 395                 400 


Gln Pro Asp Leu Gln Glu Ile Arg Glu Asn His Asn Val Tyr Asp Ser 
                405                 410                 415     


Ile Arg Ser Lys Leu Tyr Lys Met Met Asp Phe Val Leu Val Tyr Ala 
            420                 425                 430         


Tyr Ser Asn Glu Arg Lys Ser Lys Ala Asp Ala Leu Ala Ser Asn Leu 
        435                 440                 445             


Arg Ser Ala Ile Thr Glu Asp Ala Lys Lys Arg Val Tyr Gln Asn Glu 
    450                 455                 460                 


Ala Asp Gln Leu Trp Thr Ser Tyr Gln Glu Leu Phe Lys Arg Ile Arg 
465                 470                 475                 480 


Gly Phe Lys Gly Ala Gln Val Lys Glu Tyr Ser Ser Gln Asn Met Pro 
                485                 490                 495     


Ile Pro Ile Gln Lys Gln Ile Gln Asn Ile Leu Lys Pro Ala Glu Gln 
            500                 505                 510         


Val Thr Cys Phe Thr Lys Leu Met Tyr Leu Leu Thr Met Phe Leu Asp 
        515                 520                 525             


Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp 
    530                 535                 540                 


Asn Ile Ser Ser Leu Leu Lys Thr Met Glu Gln Leu Glu Leu Gln Thr 
545                 550                 555                 560 


Thr Phe Lys Glu Asp Tyr Thr Phe Phe Gln Gln Ser Ser Cys Leu Cys 
                565                 570                 575     


Glu Glu Ile Thr Gln Leu Lys Ser Phe Ala Arg Met Gly Asn Pro Ile 
            580                 585                 590         


Ser Asn Leu Lys Glu Val Met Met Val Asp Ala Ile Gln Ile Leu Gly 
        595                 600                 605             


Thr Glu Lys Ser Glu Gln Glu Leu Gln Ser Met Ala Cys Phe Phe Phe 
    610                 615                 620                 


Arg Asp Lys Asn Gly Lys Lys Leu Asn Ala Gly Glu His Gly Met Arg 
625                 630                 635                 640 


Asn Phe Ile Gly Asn Asn Val Ile Ser Asn Thr Arg Phe Gln Tyr Leu 
                645                 650                 655     


Ile Arg Tyr Gly Asn Pro Gln Lys Leu His Thr Leu Ser Gln Asn Glu 
            660                 665                 670         


Thr Val Val Arg Phe Val Leu Ser Arg Ile Ala Lys Asn Gln Arg Val 
        675                 680                 685             


Gln Gly Met Asn Gly Lys Asn Gln Ile Asp Arg Tyr Tyr Glu Thr Cys 
    690                 695                 700                 


Gly Gly Thr Asn Ser Trp Ser Val Ser Glu Glu Glu Lys Ile Asn Phe 
705                 710                 715                 720 


Leu Cys Lys Ile Leu Thr Asn Met Ser Tyr Asp Gln Phe Gln Asp Val 
                725                 730                 735     


Lys Gln Ser Asp Lys Ile Ile Thr Ala Glu Glu Lys Arg Lys Lys Glu 
            740                 745                 750         


Arg Tyr Lys Ala Ile Ile Ser Leu Tyr Leu Thr Val Leu Tyr Gln Leu 
        755                 760                 765             


Ile Lys Asn Leu Val Asn Ile Asn Ala Arg Tyr Ile Ile Ala Phe His 
    770                 775                 780                 


Cys Leu Glu Arg Asp Ala Ile Leu Tyr Ser Leu Lys Phe Asn Thr Ser 
785                 790                 795                 800 


Ile Asn Leu Lys Lys Arg Tyr Thr Ala Leu Thr Glu Met Ile Leu Gly 
                805                 810                 815     


Tyr Glu Thr Asp Glu Lys Ala Arg Arg Lys Asp Thr Arg Thr Ile Tyr 
            820                 825                 830         


Glu Lys Ala Glu Ala Ala Lys Asn Arg His Leu Lys Asn Val Lys Trp 
        835                 840                 845             


Asn Cys Lys Thr Arg Glu Asn Leu Glu Asn Ala Asp Lys Asn Ala Ile 
    850                 855                 860                 


Val Ala Phe Arg Asn Ile Val Ala His Leu Trp Ile Ile Arg Asp Ala 
865                 870                 875                 880 


Asp Arg Phe Ile Thr Glu Met Gly Ala Met Lys Arg Tyr Phe Asp Cys 
                885                 890                 895     


Tyr His Tyr Leu Leu Gln Arg Glu Leu Glu Tyr Ile Leu Glu Lys Ser 
            900                 905                 910         


Asn Gln Gly Ser Lys Tyr Thr Lys Lys Ser Leu Glu Lys Val Gln Gln 
        915                 920                 925             


Tyr His Ser Tyr Cys Lys Asp Phe Leu His Met Leu Cys Leu Pro Phe 
    930                 935                 940                 


Ala Tyr Cys Ile Pro Arg Tyr Lys Asn Leu Ser Ile Ala Glu Leu Phe 
945                 950                 955                 960 


Asp Arg His Glu Leu Glu Ala Glu Pro Lys Glu Glu Ala Ser Pro Ala 
                965                 970                 975     


Asn Asn Ser Gln Phe Ile Thr Thr 
            980                 


<210>  2870
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2870

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Phe 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Glu Asp Ser Ser Asn Ile Glu Leu Cys Gly Val Thr Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Leu Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Met Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Lys Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Leu Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Asp Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Asp Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Thr Leu Ser Gln Thr Leu Cys Gly 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Asn Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr 
    850                 855                 860                 


Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  2871
<211>  936
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2871

Met Ser Asn Lys Ser Ile Ala Lys Ala Ser Gly Leu Lys Ser Thr Phe 
1               5                   10                  15      


Lys Ile Gly Lys Asp Thr Tyr Leu Met Thr Ser Phe Gly Arg Gly Asn 
            20                  25                  30          


Thr Ala Leu Ala Glu Lys Asp Ile Lys Glu Gly Thr Ile Glu Asp Ile 
        35                  40                  45              


Leu His Thr Phe Ser Ala Phe Leu Ile Gly Asp Lys Asp Val Arg Ile 
    50                  55                  60                  


Gln Lys Asn Lys Leu His Ala Val Val Gln Leu Pro Val Gln Asp His 
65                  70                  75                  80  


Asn Gln Leu Gln Ala Lys Ser Ala Ile Glu Lys Ile Phe Phe Gly Ala 
                85                  90                  95      


Ser Tyr Glu Asp Asn Phe His Val Gln Ile Ala Tyr Asn Val Met Asp 
            100                 105                 110         


Ile Lys Lys Leu Leu Thr Val Tyr Ala Asn Asn Ile Val Phe Thr Val 
        115                 120                 125             


Asn Asn Leu Leu Arg Ile Glu Asp Glu Asp Phe Leu Gly Val Phe Gly 
    130                 135                 140                 


Val Met Asn Asp Phe Glu Lys Ala Gln Ile Ala Tyr Ala Ile Ile Ser 
145                 150                 155                 160 


Thr Gly Leu Ile Thr Arg Asp Lys Gly Thr Asn Pro Thr Tyr Tyr Ile 
                165                 170                 175     


Asn Asn Asn Val Trp Asn Lys Asn Gln Asn Gly Leu Leu Ala Thr Leu 
            180                 185                 190         


Lys Asn Arg Val Asn Gln His Lys Asn Pro Lys Ile Leu Phe Phe Thr 
        195                 200                 205             


Asn Val Ser Asn Tyr Ile Val Asn His Leu Gly Phe Arg Lys Phe Ser 
    210                 215                 220                 


Asp Ile Gln Lys Ala Ala Lys Ser Phe Glu Ser Ile Lys Lys Met Gly 
225                 230                 235                 240 


Leu Asp Lys Cys Ala Asn Tyr Phe Ser Asp Ala Phe Ser Asp Ser Asn 
                245                 250                 255     


Gly Asn Ile Asp Leu Glu Phe Ile Tyr Glu Ser Leu Arg Leu Leu Gly 
            260                 265                 270         


Ser Met Arg Gln Thr Ala Phe His Ser Tyr Asp Ile Asn Gly Met Ser 
        275                 280                 285             


Pro Gly Gly Lys Asn Phe Tyr Ser Leu Phe Asp Ile Asp Ile Lys Ala 
    290                 295                 300                 


Ser Ala Arg Thr Lys Glu Ile Ile Asp Thr Ile Thr Gly Asn Lys Leu 
305                 310                 315                 320 


Asn Ala Leu Asn Glu Asn Phe Val Glu Thr Asn Thr Val Asn Leu Asn 
                325                 330                 335     


Ile Leu Phe Ser Ala Tyr Pro His Ile Glu Lys Lys Glu Leu Val Lys 
            340                 345                 350         


Gln Phe Tyr Asp Phe Ser Val Arg Lys Val Phe Lys Asn Met Gly Phe 
        355                 360                 365             


Ser Val Lys Asn Leu Arg Glu Asn Ile Leu Ala Asn Glu Pro Ala Val 
    370                 375                 380                 


Lys Glu Leu Asn Gly Lys Lys Tyr Asp Ser Val Arg Ser Lys Leu Tyr 
385                 390                 395                 400 


Ser Leu Met Asp Phe Val Ile Tyr Asn Tyr Tyr Leu Ser His Pro Gln 
                405                 410                 415     


Glu Ala Asp Asp Phe Ile Glu Phe Ile Arg Met Asn Cys Val Ser Lys 
            420                 425                 430         


Arg Asp Ala Lys Leu Glu Lys Ile Glu Asp Glu Lys Lys Gln Ala Ile 
        435                 440                 445             


Tyr Arg Glu Glu Ser Ala Arg Leu Trp Lys Gln Ile Ser Gly Ile Val 
    450                 455                 460                 


Leu Glu Asn Ile Leu Pro Gly Ile Asp Lys Val Gln Ser Arg Asp Lys 
465                 470                 475                 480 


Lys Leu Asn Lys Gly Leu Asp Ser Glu Leu Gln Lys Ala Val Leu Ser 
                485                 490                 495     


Val Val Gln Thr Pro Asp Asp Leu Asn Tyr Phe Ala Lys Ala Met Tyr 
            500                 505                 510         


Cys Ile Cys Ala Phe Leu Asp Gly Lys Glu Ile Asn Met Phe Leu Asp 
        515                 520                 525             


Ser Leu Ile Asn Ser Phe Glu Asn Ile Glu Ser Leu Arg Glu Ile Ala 
    530                 535                 540                 


Ala Glu Val Asn Cys Pro Val Glu Phe Asn Ser Ser Tyr Ser Phe Phe 
545                 550                 555                 560 


Asn His Cys Gly Lys Met Ala Asp Glu Leu Arg Phe Ile Lys Ser Ile 
                565                 570                 575     


Ala Arg Met Asn Lys Gly Lys Lys Ala Ser Lys Asn Ser Lys Leu His 
            580                 585                 590         


Ile Lys Ser Tyr Gln Tyr Phe Asp Ser Ala Ala Ile Leu Gly Glu Tyr 
        595                 600                 605             


Asp Glu Glu Lys Ile Lys Glu Leu Phe Arg Leu Glu Glu Arg Thr Gln 
    610                 615                 620                 


Lys Gly Gln Lys Val Asp His Thr Leu Arg Asn Phe Phe Ile Asn Asn 
625                 630                 635                 640 


Val Ile Val Ser Asn Arg Phe Asn Tyr Val Ile Arg Phe Ile Asn Pro 
                645                 650                 655     


Lys His Ala Arg Ala Ile Met Glu Asn Glu Ala Leu Val Ser Phe Thr 
            660                 665                 670         


Leu Gln Glu Ile Asp Glu Lys Gln Ile Ile Arg Tyr Tyr Leu Ser Val 
        675                 680                 685             


Arg Asn Asn Glu Asp Pro Leu Glu Ala Asp Ser Asp Tyr Met Arg Lys 
    690                 695                 700                 


Lys Leu Val Asp Lys Leu Met Asn Val Ser Phe Ser Ala Phe Glu Lys 
705                 710                 715                 720 


Val Ser Asn Asp Ser Ser Glu Ala Val Glu Lys Glu Arg Leu Lys Ala 
                725                 730                 735     


Leu Val Gly Leu Tyr Leu Thr Ile Ile Tyr Leu Ile Ala Lys Ala Leu 
            740                 745                 750         


Val Arg Ile Asn Thr Ser Tyr Ser Ile Ala Phe Gly Ile Phe Glu Arg 
        755                 760                 765             


Asp Cys Glu Ile Ile Lys Gln Lys Ala His Asp Glu Lys Asn Val Ser 
    770                 775                 780                 


Leu Glu Asp Lys Met Lys Ile Ile Leu Ser Lys Asn Lys Glu Asp Pro 
785                 790                 795                 800 


Glu Pro Glu Tyr Cys Ser Ile Thr Gln Tyr Phe Asp Asp Cys Gly Arg 
                805                 810                 815     


Ile Asn Arg Arg Val Lys Arg Leu Ile Glu Arg Asn Ser Ile His Tyr 
            820                 825                 830         


Asp Glu Asn Thr Phe Arg Lys Ile Arg Asn Cys Ala Glu His Leu Ser 
        835                 840                 845             


Val Val Ser Ser Phe Pro Ala Tyr Val Ser Glu Ile Lys Arg Val Glu 
    850                 855                 860                 


Ser Tyr Phe Asp Leu Tyr His Tyr Ile Leu Leu Arg Val Leu Lys Asp 
865                 870                 875                 880 


Gly Ala His Ile Lys Gln Glu Ala Thr Leu Lys Gly Tyr Glu Ala Val 
                885                 890                 895     


Leu Arg His Gln Thr Ala Tyr Lys Asp Tyr Leu Tyr Gly Ile Leu Ala 
            900                 905                 910         


Pro Phe Ala Tyr Asn Gln Ala Arg Tyr Ile Asn Leu Ala Cys Lys Lys 
        915                 920                 925             


Arg Phe Ile Lys Ser Tyr Gly Lys 
    930                 935     


<210>  2872
<211>  923
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2872

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Val Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Lys Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asp Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asp Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Lys Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Asn Ala 
            260                 265                 270         


Leu Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu His Glu 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Ile Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Asp Asp Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile 
        355                 360                 365             


Val Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg 
    370                 375                 380                 


Glu Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe 
                405                 410                 415     


Cys Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg 
            420                 425                 430         


Lys Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala 
        435                 440                 445             


Asp Glu Ala Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn 
    450                 455                 460                 


Ile Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala 
465                 470                 475                 480 


Asp Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala 
                485                 490                 495     


Ser Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe 
            500                 505                 510         


Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys 
        515                 520                 525             


Phe Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val 
    530                 535                 540                 


Asp Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser 
545                 550                 555                 560 


Gln Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met 
                565                 570                 575     


Arg Lys Pro Ala Ser Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu 
            580                 585                 590         


Thr Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu 
        595                 600                 605             


Ile Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn 
    610                 615                 620                 


Phe Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile 
625                 630                 635                 640 


Lys Tyr Ala Asn Ala Gln Lys Ile Arg Lys Val Ala Lys Asn Glu Lys 
                645                 650                 655     


Val Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg 
            660                 665                 670         


Tyr Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu 
        675                 680                 685             


Val Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp 
    690                 695                 700                 


Asp Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala 
705                 710                 715                 720 


Lys Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr 
                725                 730                 735     


Leu Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala 
            740                 745                 750         


Ile His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro 
        755                 760                 765             


Glu Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln 
    770                 775                 780                 


Thr Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys 
785                 790                 795                 800 


Asn Arg Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp 
                805                 810                 815     


Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val 
            820                 825                 830         


Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser 
        835                 840                 845             


Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg 
    850                 855                 860                 


Glu Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu 
865                 870                 875                 880 


Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser 
                885                 890                 895     


Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln 
            900                 905                 910         


Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920             


<210>  2873
<211>  918
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2873

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Gly Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Asn Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp 
    370                 375                 380                 


Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Gly Val Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ser Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu Arg 
785                 790                 795                 800 


Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr Arg 
                805                 810                 815     


Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu Lys 
            820                 825                 830         


Glu Tyr Ile Gly Asp Ile Cys Thr Val Asp Ser Tyr Phe Ser Ile Tyr 
        835                 840                 845             


His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr Lys 
    850                 855                 860                 


Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His Gly 
865                 870                 875                 880 


Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr Asn 
                885                 890                 895     


Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg Asn 
            900                 905                 910         


Glu Tyr Leu Thr Glu Lys 
        915             


<210>  2874
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2874

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Gln Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Ser Val Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Gln Asn Thr Tyr Tyr Ile 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val 
            260                 265                 270         


Ser Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu 
    290                 295                 300                 


Tyr Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Val Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Ile Ala Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Leu Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Asn Arg Asp Glu Ser Pro Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asp Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  2875
<211>  926
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2875

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Val Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Phe 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Glu Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Asp Glu Ser His Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile Asn Lys 
225                 230                 235                 240 


Val Lys Gly Asn Ile Lys Lys Ser Phe Ser Thr Phe Asn Asp Leu Leu 
                245                 250                 255     


Lys Thr Lys Arg Leu Gly Tyr Phe Gly Phe Glu Glu Pro Lys Thr Lys 
            260                 265                 270         


Asp Thr Arg Val Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu 
        275                 280                 285             


Ala Ile Val Gly Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Ser 
    290                 295                 300                 


Lys Leu Asp Glu Asp Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu 
305                 310                 315                 320 


Tyr Arg Glu Thr Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile 
                325                 330                 335     


Asn Lys Gly Phe Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile 
            340                 345                 350         


Asp Met Met Lys Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr 
        355                 360                 365             


Asp Phe Ile Val Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys 
    370                 375                 380                 


Lys Leu Arg Glu Lys Met Leu Glu Glu Tyr Gly Tyr Arg Phe Lys Asp 
385                 390                 395                 400 


Lys Gln Tyr Asp Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe 
                405                 410                 415     


Leu Leu Phe Cys Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala 
            420                 425                 430         


Leu Val Arg Lys Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly 
        435                 440                 445             


Ile Tyr Ala Asp Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp 
    450                 455                 460                 


Phe Glu Asn Ile Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu 
465                 470                 475                 480 


Gly Lys Ala Asp Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys 
                485                 490                 495     


Lys Asn Ala Ser Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu 
            500                 505                 510         


Thr Tyr Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu 
        515                 520                 525             


Ile Ser Lys Phe Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser 
    530                 535                 540                 


Ser Ala Val Asp Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe 
545                 550                 555                 560 


Asn Asp Ser Gln Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile 
                565                 570                 575     


Ala Ser Met Arg Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg 
            580                 585                 590         


Asp Ala Leu Thr Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg 
        595                 600                 605             


Ile Ser Glu Ile Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly 
    610                 615                 620                 


Leu Arg Asn Phe Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val 
625                 630                 635                 640 


Tyr Leu Ile Lys Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys 
                645                 650                 655     


Asn Glu Lys Val Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln 
            660                 665                 670         


Ile Glu His Tyr Tyr Lys Ser Cys Val Glu Val Pro Asp Val Asn Ser 
        675                 680                 685             


Ser Leu Glu Ala Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile 
    690                 695                 700                 


Ser Phe Asp Asp Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu 
705                 710                 715                 720 


Asn Val Ala Lys Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr 
                725                 730                 735     


Val Met Tyr Leu Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr 
            740                 745                 750         


Val Ile Ala Ile His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu 
        755                 760                 765             


Ile Ile Pro Glu Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile 
    770                 775                 780                 


Leu Ser Gln Thr Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe 
785                 790                 795                 800 


Leu Lys Lys Asn Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn 
                805                 810                 815     


Asn Ala Asp Ser Asn Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His 
            820                 825                 830         


Leu Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr 
        835                 840                 845             


Val Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile 
    850                 855                 860                 


Thr Lys Arg Glu Asp Asp Lys Lys Gln Glu Glu Lys Ile Lys Phe Glu 
865                 870                 875                 880 


Asp Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala 
                885                 890                 895     


Leu Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser 
            900                 905                 910         


Ile Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925     


<210>  2876
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2876

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Phe Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Asn Arg Val Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Ile Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Leu Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Lys Val Ala Glu Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp Asp Lys 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Phe Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  2877
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2877

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Asp Gly Ser Ser Asn Ile Glu Leu Arg Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Gln Asn Thr Tyr Tyr Ile Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu Tyr Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Val Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Glu 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ser Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Lys Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Arg Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  2878
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2878

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Gly Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asp Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Ser Ser Asn Ile Glu Leu His Gly 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Glu Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu 
    290                 295                 300                 


Asp Leu Tyr Gly Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Ile Ala Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Val Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Arg Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Lys Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Val Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Asp Arg Asp Lys Ser Pro Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Ile Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Arg Ile Thr 
    850                 855                 860                 


Lys Arg Lys Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  2879
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2879

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Gln Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ser Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Pro Leu Glu Ala 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Ile Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2880
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2880

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Ile Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Pro Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn His Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2881
<211>  921
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2881

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Lys Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Val 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys Arg Gly Asn Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn 
        195                 200                 205             


Tyr Asp Phe Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe 
    210                 215                 220                 


Thr Asn Pro Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile 
225                 230                 235                 240 


Arg Lys Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu 
                245                 250                 255     


Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser 
            260                 265                 270         


Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln 
        275                 280                 285             


Ile Arg Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp 
    290                 295                 300                 


Leu Tyr Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu 
305                 310                 315                 320 


Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile 
                325                 330                 335     


Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly 
            340                 345                 350         


Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu 
        355                 360                 365             


Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys 
    370                 375                 380                 


Met Leu Glu Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp Ser 
385                 390                 395                 400 


Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn 
                405                 410                 415     


Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu 
            420                 425                 430         


Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu 
        435                 440                 445             


Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala 
    450                 455                 460                 


Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met 
465                 470                 475                 480 


Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp 
                485                 490                 495     


Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp 
            500                 505                 510         


Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp 
        515                 520                 525             


Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val 
    530                 535                 540                 


Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg 
545                 550                 555                 560 


Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys 
                565                 570                 575     


Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile 
            580                 585                 590         


Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu 
        595                 600                 605             


Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile 
    610                 615                 620                 


Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr 
625                 630                 635                 640 


Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val 
                645                 650                 655     


Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr 
            660                 665                 670         


Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Gly Val Lys 
        675                 680                 685             


Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe 
    690                 695                 700                 


Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu 
705                 710                 715                 720 


Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu 
                725                 730                 735     


Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His 
            740                 745                 750         


Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu 
        755                 760                 765             


Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu 
    770                 775                 780                 


Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu 
785                 790                 795                 800 


Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser 
                805                 810                 815     


Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg 
            820                 825                 830         


Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe 
        835                 840                 845             


Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp 
    850                 855                 860                 


Asp Ile Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys 
865                 870                 875                 880 


Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe 
                885                 890                 895     


Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe 
            900                 905                 910         


Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920     


<210>  2882
<211>  1023
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2882

Met Gly Glu Glu Lys Lys Asp Ser Tyr Gly Thr Lys Lys Lys Ser Trp 
1               5                   10                  15      


Pro Lys Cys Tyr Gly Leu Lys Ser Val Leu Asp Tyr Gln Gly His Ile 
            20                  25                  30          


Val Val Thr Ser Val Ala Lys Glu Ala Asp Thr Ala Lys Asn Glu Thr 
        35                  40                  45              


Gly Gly Phe Asp Gln Glu Thr Gln Pro Asp Cys Thr Leu Ile Arg Gly 
    50                  55                  60                  


Val Asp Asp Met Glu Phe Ser Leu Ala Asp Gly Glu Lys Lys Ile Lys 
65                  70                  75                  80  


Val Lys Ala Lys Asp Ala Lys Gln Asp Phe Leu Val Glu Lys Pro Phe 
                85                  90                  95      


Ser Tyr Ala Lys Thr Glu Asp Gly Ala Pro Lys Leu Ser Pro Lys Glu 
            100                 105                 110         


Asp Tyr Leu Gly Ile Ala Lys Tyr Ile Cys His Asp Ile Phe Gly Gln 
        115                 120                 125             


Pro Leu Glu Glu Arg Tyr Asp Asp Asn Ile His Tyr Gln Ile Ala Tyr 
    130                 135                 140                 


Asn Ile Ala Asp Leu Glu Lys Ile Ile Phe Tyr Glu Val Asn Asp Ala 
145                 150                 155                 160 


Cys Phe Ala Val Asp Asn Ile Leu Lys Ala Lys Asp Phe Asp Glu Ala 
                165                 170                 175     


Ala Ser Leu Arg Pro Ile Asp Arg Ser Thr Leu Ser Lys Glu Glu Val 
            180                 185                 190         


Lys Arg Ala Glu Met Glu Arg Asp Phe Ile Gly Glu Phe Asn Pro Lys 
        195                 200                 205             


Pro Thr Phe Asn Glu Glu Val Ala Phe Ala Ala Ser Lys Pro Thr Asp 
    210                 215                 220                 


Glu Asp Gly Lys Ala Lys Val Met Ala Ala Asn Val Gln Leu Asp Thr 
225                 230                 235                 240 


Phe Ala Arg Phe Asn Arg Leu Ala Glu Pro Tyr Ser Pro Phe Phe Asn 
                245                 250                 255     


Ser Leu Phe Ile Tyr Arg Asp Lys Lys Ile Glu Ser Arg Lys Gln Pro 
            260                 265                 270         


Gly Asp Asp Tyr Phe Ala Glu His Asn Tyr Asn Val Ile Arg Val Leu 
        275                 280                 285             


Ala Ser Leu Arg His Phe Phe Thr His Arg Thr Trp Gly Lys Ala Asp 
    290                 295                 300                 


Val Ala Asp Gly Glu Ala Ser Asp Thr Ser Phe Phe Asp Phe Ser His 
305                 310                 315                 320 


Glu Leu Val Asn Lys Tyr Lys Gly Val Ala Asp Phe Ala Ser Met Thr 
                325                 330                 335     


Phe Ala Asn Lys Ala Asn Glu Leu Asn Glu Ser Phe Ala Asn Thr Cys 
            340                 345                 350         


Ala Thr Asp Leu Val Ile Leu Cys Ala Tyr Phe Gly Thr Asp Thr Lys 
        355                 360                 365             


Asp Glu Ala Gly Val Arg Lys His Leu Arg Ser Tyr Tyr Asp Phe Val 
    370                 375                 380                 


Val Gly Glu Ser Ala Lys Asn Ile Gly Ile Asn Met Thr Lys Val Arg 
385                 390                 395                 400 


Glu Lys Met Ile Asp Ala His Tyr Gly Glu Gly Ser Asp Asn Asn Leu 
                405                 410                 415     


Arg Ser Lys Glu His Asp Ser Tyr Arg Gly Arg Leu Tyr Arg Leu Phe 
            420                 425                 430         


Ser Tyr Val Leu Phe Leu Asp Val Glu Ser Asp Pro Thr Lys Phe Val 
        435                 440                 445             


Asp Pro Asn Val Ala Lys Leu Arg Leu Ala Arg Thr Asp Glu Asp Lys 
    450                 455                 460                 


Gly Ala Ile Tyr Ala Gln Met Ala Glu Asp Cys Phe Gln Ala Phe Lys 
465                 470                 475                 480 


Asp Asp Phe Ser Glu Met Ile Arg Leu Val Arg Glu Asn Val Arg Ile 
                485                 490                 495     


Asn Gly Glu Lys Ser Lys Gln Lys Phe Pro Phe Ala Ile Thr Val Glu 
            500                 505                 510         


Asn Pro Leu Leu Gly Asp Glu Glu Thr Leu Ile Phe Val Gln Met Val 
        515                 520                 525             


Phe Phe Leu Ser Leu Phe Leu Gly Glu Lys Glu Ser Asn Asp Leu Leu 
    530                 535                 540                 


Thr Ser Leu Ser Asn Lys Phe Asp Asn Ile Val Gln Phe Met Lys Val 
545                 550                 555                 560 


Leu Val Phe Leu Asp Pro Glu His Lys Gln Val His Ile Asn Gly Lys 
                565                 570                 575     


Tyr Ser Leu Phe Arg Val Glu Asn Ala Glu Lys Ile Ala Thr Gln Leu 
            580                 585                 590         


Arg Val Ala Gln Lys Val Ser Arg Met Arg Lys Asn Leu Lys Lys Ala 
        595                 600                 605             


Asp Val Ser Ala Ser Leu Leu Gly Glu Ala Met Asn Val Phe Ser Arg 
    610                 615                 620                 


His Asp Phe Tyr Ala Pro Asp Asp Val Gly Ala Asp Gly Lys Val Val 
625                 630                 635                 640 


Arg Asp Pro Arg Leu Ala Lys Met Leu Asp Asp Thr Phe Asn Ser Lys 
                645                 650                 655     


Lys Gly Ser Asp Asp Arg Thr Phe Arg Asn Phe Leu Leu Asn Asn Val 
            660                 665                 670         


Leu Ala Ser Arg Arg Phe Ala Tyr Ile Ile Arg Tyr Phe Asp Ala Arg 
        675                 680                 685             


Gly Val Arg Arg Leu Met Asp Ala Asp Ser Ala Val Arg Phe Val Leu 
    690                 695                 700                 


Gly Thr Ile Pro Glu Thr Gln Ile Arg Arg Tyr Tyr Gly Val Met Ala 
705                 710                 715                 720 


Gln Asn Pro Ala Pro Leu Pro Gln Met Ile Asp Phe Leu Ala Ser Gln 
                725                 730                 735     


Met Lys Leu Leu Asp Ile Asp Phe Leu Leu Gly Lys Lys Gly Ala Met 
            740                 745                 750         


Gln Gln Trp Ala Lys Ser Val Gly Arg Val Pro Ala Asp Lys Gln Val 
        755                 760                 765             


Phe Leu Thr Gln Val Gly Leu Tyr Leu Thr Val Ala Tyr Leu Ile Val 
    770                 775                 780                 


Lys Asn Val Val Asn Ala Asn Ala Arg Phe Ser Ser Ala Phe Ala Ser 
785                 790                 795                 800 


Tyr Glu Cys Asp Arg Ser Leu Tyr Ala Lys Ser Met Gly Glu Lys Ala 
                805                 810                 815     


Val Ser Lys Ala Gly Gly Asp Leu Asn Ser Tyr Asp Ala Asp Leu Thr 
            820                 825                 830         


Arg Phe Phe Ile Gly Gln Leu Pro Gly Lys Asp Ala Asp Gly Asn Asp 
        835                 840                 845             


Ala Leu Val Gly Leu Asn Lys Tyr Tyr Phe Lys Ser Gln Arg Tyr Leu 
    850                 855                 860                 


Leu Asp Tyr Cys Arg Tyr Phe Glu Arg Leu Glu Lys Glu Cys Asn Ile 
865                 870                 875                 880 


Asp Lys Leu Ser Val Gly Lys Leu Tyr Arg Asn His Val Val His Leu 
                885                 890                 895     


Asn Tyr Ile Ala Gly Leu Ala Asn Ile Lys Glu Ile Glu His Val Arg 
            900                 905                 910         


Ser Tyr Tyr Asp Ile Tyr Val Tyr Leu Val Glu Lys Gly Met Val Thr 
        915                 920                 925             


Ser Phe Glu Asp Pro Ala Thr Lys Ala Ile Val Leu Ala Ser Val Pro 
    930                 935                 940                 


Ser Asp Gly Ala Asp Lys Pro Ala Asp Lys Ser Leu Leu Ala Asp Leu 
945                 950                 955                 960 


Lys Phe Ser Leu Asp Lys Tyr His Ser Tyr Ser Trp Met Phe Phe Lys 
                965                 970                 975     


Trp Leu Asn Ala Met Phe Gly Tyr Cys Leu Pro Arg Phe Gln Asn Leu 
            980                 985                 990         


Thr Thr Ala Asn Leu Phe Asn Glu  Arg Asp Tyr Gly Arg  Ser Val Ile 
        995                 1000                 1005             


Lys Arg  Pro Glu Pro Lys Ser  Gln Phe Asp Ala Ala  Lys Ala Lys 
    1010                 1015                 1020             


<210>  2883
<211>  933
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2883

Met Leu Leu Cys Ala Ile Met Gln Ala Ser Thr Lys Lys Asp Arg Lys 
1               5                   10                  15      


Gly Gly Val Arg Met Glu Arg Glu Val Lys Lys Pro Pro Lys Lys Ser 
            20                  25                  30          


Leu Ala Lys Ala Ala Gly Leu Lys Ser Thr Phe Val Ile Ser Pro Gln 
        35                  40                  45              


Glu Lys Glu Leu Ala Met Thr Ala Phe Gly Arg Gly Asn Asp Ala Leu 
    50                  55                  60                  


Leu Gln Lys Arg Ile Val Asp Gly Val Val Arg Asp Val Ala Gly Glu 
65                  70                  75                  80  


Lys Gln Gln Phe Gln Val Gln Arg Gln Asp Glu Ser Arg Phe Arg Leu 
                85                  90                  95      


Gln Asn Ser Arg Leu Ala Asp Arg Thr Val Thr Ala Asp Asp Pro Leu 
            100                 105                 110         


His Arg Ala Glu Ala Pro His Arg Gln Pro Leu Gly Ala Gly Met Asp 
        115                 120                 125             


Gln Leu Arg Arg Lys Ala Val Leu Glu Gln Lys Tyr Phe Gly Arg Thr 
    130                 135                 140                 


Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile 
145                 150                 155                 160 


His Lys Met Leu Ala Val Pro Ala Asn His Ile Val His Thr Leu Asn 
                165                 170                 175     


Leu Leu Gly Gly Tyr Gly Glu Thr Asp Phe Val Gly Met Leu Pro Ala 
            180                 185                 190         


Gly Leu Pro Tyr Asp Lys Leu Arg Met Pro Asp Ala Gly Asp Thr Arg 
        195                 200                 205             


Arg Asn Val Lys Arg Asp Val Lys Ala Asp Ile Ala Ala Tyr Ala Lys 
    210                 215                 220                 


Arg Pro Gln Leu Ala Tyr Leu Gly Ala Ala Phe Tyr Asp Val Thr Pro 
225                 230                 235                 240 


Gly Lys Ser Lys Arg Asp Ala Ala Arg Ser Arg Val Lys Arg Glu Gln 
                245                 250                 255     


Asp Val Tyr Thr Ile Leu Ser Leu Met Ser Leu Leu Arg Gln Phe Cys 
            260                 265                 270         


Ala His Asp Ser Val Arg Ile Trp Gly Gln Asn Thr Pro Ala Ala Leu 
        275                 280                 285             


Tyr His Leu Gln Ala Leu Pro Gln Asp Met Lys Asp Leu Leu Asp Asp 
    290                 295                 300                 


Gly Trp Arg Arg Ala Leu Gly Gly Val Asn Asn His Phe Leu Asp Thr 
305                 310                 315                 320 


Asn Lys Val Asn Leu Leu Thr Leu Phe Glu Tyr Tyr Gly Ala Asp Ala 
                325                 330                 335     


Lys Gln Glu Arg Val Ala Leu Thr Gln Asp Phe Tyr Arg Phe Val Val 
            340                 345                 350         


Leu Lys Glu Gln Lys Asn Met Gly Phe Ser Leu Arg Arg Leu Arg Glu 
        355                 360                 365             


Glu Leu Leu Lys Leu Pro Asp Ala Ala Tyr Leu Thr Gly Gln Lys Tyr 
    370                 375                 380                 


Asp Ser Val Arg Gln Lys Leu Tyr Met Leu Leu Asp Phe Leu Leu Cys 
385                 390                 395                 400 


Arg Leu Tyr Ala Gln Glu Arg Ala Asp Arg Cys Glu Glu Leu Val Ser 
                405                 410                 415     


Ala Leu Arg Cys Ala Leu Ser Asn Glu Glu Arg Asp Ala Val Tyr Gln 
            420                 425                 430         


Ala Glu Ala Ala Ala Leu Trp Gln Ala Leu Gly Asp Thr Leu Arg Arg 
        435                 440                 445             


Lys Leu Leu Pro Leu Leu Lys Gly Lys Lys Leu Gln Asp Lys Asp Lys 
    450                 455                 460                 


Lys Thr Leu Asp Glu Leu Gly Leu Ser Arg Asp Val Leu Asp Gly Val 
465                 470                 475                 480 


Leu Phe Arg Pro Ala Gln Gln Gly Ser Arg Ala Asn Ala Asp Tyr Phe 
                485                 490                 495     


Cys Arg Leu Met His Leu Ser Thr Trp Phe Met Asp Gly Lys Glu Ile 
            500                 505                 510         


Asn Thr Leu Leu Thr Thr Leu Ile Ser Lys Leu Glu Asn Ile Asp Ser 
        515                 520                 525             


Leu Arg Asn Val Leu Glu Ser Met Gly Leu Ser Cys Ser Phe Val Pro 
    530                 535                 540                 


Ala Tyr Ala Met Phe Asp His Ser Arg Tyr Ile Ala Gly Gln Leu Arg 
545                 550                 555                 560 


Val Val Asn Asn Ile Ala Arg Met Arg Lys Pro Ala Ile Thr Ala Lys 
                565                 570                 575     


Arg Glu Met Tyr Arg Ala Ala Val Val Leu Leu Gly Val Asp Ser Pro 
            580                 585                 590         


Glu Ala Ala Ala Ala Ile Thr Asp Asp Leu Leu Gln Ile Asp Pro Glu 
        595                 600                 605             


Thr Gly Lys Val Arg Pro Arg Gly Asp Ser Ala Arg Asp Thr Gly Leu 
    610                 615                 620                 


Arg Asn Phe Ile Ala Asn Asn Val Val Glu Ser Arg Arg Phe Thr Tyr 
625                 630                 635                 640 


Leu Leu Arg Tyr Met Thr Pro Glu Gln Ala Arg Ala Leu Ala Gln Asn 
                645                 650                 655     


Glu Lys Leu Ile Ala Phe Val Leu Ser Thr Val Pro Asp Thr Gln Leu 
            660                 665                 670         


Glu Arg Tyr Cys Arg Thr Cys Gly Arg Glu Asp Ile Thr Gly Arg Pro 
        675                 680                 685             


Ala Gln Ile Arg Tyr Leu Thr Ala Gln Ile Met Gly Val Arg Tyr Glu 
    690                 695                 700                 


Ser Phe Thr Asp Val Glu Gln Arg Gly Arg Gly Asp Asn Pro Lys Lys 
705                 710                 715                 720 


Glu Arg Tyr Lys Ala Leu Ile Gly Leu Tyr Leu Thr Val Leu Tyr Leu 
                725                 730                 735     


Ala Val Lys Asn Met Val Asn Cys Asn Ala Arg Tyr Val Ile Ala Phe 
            740                 745                 750         


Tyr Cys Arg Asp Arg Asp Thr Ala Leu Tyr Gln Lys Glu Val Cys Trp 
        755                 760                 765             


Tyr Asp Leu Glu Glu Asp Lys Lys Ser Gly Lys Gln Arg Gln Val Glu 
    770                 775                 780                 


Asp Tyr Thr Ala Leu Thr Arg Tyr Phe Val Ser Gln Gly Tyr Leu Asn 
785                 790                 795                 800 


Arg His Ala Cys Gly Tyr Leu Arg Ser Asn Met Asn Gly Ile Ser Asn 
                805                 810                 815     


Gly Leu Leu Val Ala Tyr Arg Asn Ala Val Asp His Leu Asn Val Ile 
            820                 825                 830         


Pro Pro Leu Gly Ser Leu Cys Arg Asp Ile Gly Leu Val Asp Ser Tyr 
        835                 840                 845             


Phe Ala Leu Tyr His Tyr Ala Val Gln Gln Tyr Leu Asn Gly Arg Glu 
    850                 855                 860                 


Asn Gln Arg Pro Pro Tyr Lys Thr Ser Arg Glu Gln Glu Leu Phe Ala 
865                 870                 875                 880 


Ala Met Ala Gln His Arg Thr Trp Cys Ser Asp Leu Val Lys Ala Leu 
                885                 890                 895     


Asn Thr Pro Phe Gly Tyr Asn Leu Ala Arg Tyr Lys Asn Leu Ser Ile 
            900                 905                 910         


Asp Gly Leu Phe Asp Arg Glu Gly Asp His Val Val Arg Glu Asp Gly 
        915                 920                 925             


Glu Lys Pro Ala Glu 
    930             


<210>  2884
<211>  931
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2884

Met Glu Gly Arg Asp Met Thr Glu Thr Lys Pro Lys Arg Glu Asp Ile 
1               5                   10                  15      


Ala Lys Thr Pro Ala Ala Lys Ser Arg Ser Lys Ala Ala Gly Leu Lys 
            20                  25                  30          


Ser Thr Phe Ala Val Asn Gly Ser Val Leu Leu Thr Ser Phe Gly Arg 
        35                  40                  45              


Gly Asn Asp Ala Val Pro Glu Lys Leu Ile Thr Glu Lys Ala Val Ser 
    50                  55                  60                  


Glu Ile Asn Thr Val Lys Pro Arg Phe Ser Val Glu Lys Pro Ala Thr 
65                  70                  75                  80  


Ser Tyr Ser Ser Ser Phe Gly Ile Lys Ser His Ile Ser Ala Thr Ala 
                85                  90                  95      


Asp Asn Pro Leu Ala Gly Arg Ala Pro Val Gly Glu Asp Ala Ile His 
            100                 105                 110         


Ala Lys Glu Val Leu Glu Gln Arg Val Phe Gly Lys Thr Phe Ser Asp 
        115                 120                 125             


Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Arg Lys 
    130                 135                 140                 


Ile Leu Ser Thr Tyr Ala Asn Asn Val Val Phe Thr Ile Asn Ser Met 
145                 150                 155                 160 


Arg Arg Leu Asp Glu Tyr Asp Arg Glu Gln Asp Tyr Leu Gly Tyr Leu 
                165                 170                 175     


Tyr Thr Gly Asn Ser Tyr Glu Arg Leu Leu Asp Ile Ala Asp Lys Tyr 
            180                 185                 190         


Ala Val Asp Gly Glu Asp Trp Arg Asn Thr Ala Ala Gly Ile Ser Asn 
        195                 200                 205             


Asp Phe Glu Lys Lys Gln Phe Gln Thr Ile Asn Gly Phe Trp Asp Leu 
    210                 215                 220                 


Leu Asp Met Ile Glu Pro Tyr Met Cys Tyr Phe Ser Glu Ala Phe Phe 
225                 230                 235                 240 


Cys Glu Thr Thr Val Lys Asp Pro Asp Ser Gly Arg Ile Val Pro Cys 
                245                 250                 255     


Leu Glu Gln Arg Ser Asp Gly Asp Ile Tyr Asn Ile Leu Arg Ile Leu 
            260                 265                 270         


Ser Ile Val Arg Gln Thr Cys Met His Asp Asn Ala Ser Met Arg Thr 
        275                 280                 285             


Val Met Phe Thr Leu Gly Gln Asn Ser Val Arg Asp Arg Lys Asn Gly 
    290                 295                 300                 


Phe Asp Glu Leu Ala Glu Leu Leu Asp Tyr Leu Tyr Asp Glu Lys Ile 
305                 310                 315                 320 


Asp Ile Val Asn Arg Asp Phe Leu Arg Asn Gln Lys Asn Asn Ile Glu 
                325                 330                 335     


Leu Leu Ser Arg Ile Tyr Gly Ser Ser Ala Asp Ser Pro Glu Arg Asp 
            340                 345                 350         


Arg Leu Val Gln Asn Phe Tyr Asp Phe Arg Val Leu Ser Gln Asp Lys 
        355                 360                 365             


Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Leu Leu Asp Ser 
    370                 375                 380                 


Pro Ala Leu Ser Val Val Arg Ser Lys Lys Tyr Asp Thr Met Arg Ser 
385                 390                 395                 400 


Lys Ile Tyr Ser Leu Ile Asp Phe Met Ile Tyr Arg Lys Phe Ser Glu 
                405                 410                 415     


Asn His Val Ala Val Asp Asp Phe Val Glu Glu Leu Arg Ser Leu Leu 
            420                 425                 430         


Thr Glu Asp Glu Lys Glu Ser Ala Tyr Ser Arg Trp Ala Glu Thr Leu 
        435                 440                 445             


Ile Asn Asp Gly Phe Ala Gln Glu Ile Leu Val Lys Leu Leu Pro Gln 
    450                 455                 460                 


Thr Asp Pro Ala Val Ile Gly Lys Ile Lys Gly Lys Lys Leu Leu Asn 
465                 470                 475                 480 


Asp Ser Ile Ala Gly Ile Lys Leu Lys Lys Asp Ala Ser Phe Phe Thr 
                485                 490                 495     


Lys Ile Ile Asn Val Leu Cys Met Phe Gln Asp Gly Lys Glu Ile Asn 
            500                 505                 510         


Glu Leu Val Ser Ser Leu Val Asn Lys Phe Ala Asn Ile Gln Ser Phe 
        515                 520                 525             


Val Asp Val Met Arg Ser Gln Gly Ile Asp Ser Gly Phe Thr Ala Asp 
    530                 535                 540                 


Tyr Ala Met Phe Ala Glu Ser Gly Arg Ile Ser Arg Glu Leu His Ile 
545                 550                 555                 560 


Leu Lys Gly Ile Ala Arg Met Gln His Ser Ile Ala Gly Leu Gly Asp 
                565                 570                 575     


Val Lys Ile Tyr Gly Ser Asp Asp Lys Phe His Gly Val Ser Arg Arg 
            580                 585                 590         


Val Tyr Thr Asp Ala Ala Tyr Ile Leu Gly Phe Gly Glu Arg Ser Glu 
        595                 600                 605             


Asp Asn Asp Gly Tyr Val Asp Asp Tyr Val Ser Ser Lys Leu Leu Gly 
    610                 615                 620                 


Gly Ala Asp Lys Asn Leu Arg Asn Phe Ile Thr Asn Asn Val Ile Lys 
625                 630                 635                 640 


Asn Arg Arg Phe Leu Tyr Thr Val Arg Tyr Met Asn Pro Lys Arg Ala 
                645                 650                 655     


Lys Lys Leu Val Gln Asn Asp Ala Leu Val Val Leu Ala Leu Ser Gly 
            660                 665                 670         


Ile Pro Glu Thr Gln Ile Asp Arg Tyr Tyr Lys Ser Cys Ile Glu Lys 
        675                 680                 685             


Arg Ser Phe Asn Pro Asp Leu Asn Glu Lys Ile Ala Ala Leu Ser Glu 
    690                 695                 700                 


Met Ile Thr Thr Leu Lys Ile Asp Asp Phe Glu Asp Val Lys Gln Asn 
705                 710                 715                 720 


Pro Glu Lys Asn Ala Asn Tyr Glu Ala Lys Lys Asn Gln Arg Ile Ser 
                725                 730                 735     


Lys Glu Arg Tyr Lys Ala Cys Ile Gly Leu Tyr Leu Thr Val Leu Tyr 
            740                 745                 750         


Leu Ile Cys Lys Asn Leu Val Lys Ile Asn Ala Arg Tyr Ser Ile Ala 
        755                 760                 765             


Ile Gly Cys Leu Glu Arg Asp Thr Gln Leu His Gly Val Asp Phe Lys 
    770                 775                 780                 


Gly Ala Ala Tyr Met Thr Arg Asp Val Phe Ile Ala Lys Gly Trp Ile 
785                 790                 795                 800 


Asn Pro Lys Lys Pro Thr Val Lys Ser Ile Lys Glu Gln Tyr Ala Phe 
                805                 810                 815     


Leu Thr Pro Tyr Ile Phe Thr Thr Tyr Arg Asn Met Ile Ala His Leu 
            820                 825                 830         


Ala Ala Val Thr Asn Ala Tyr Lys Tyr Ile Pro Gln Met Asp Arg Phe 
        835                 840                 845             


Lys Ser Trp Phe His Leu Tyr His Thr Val Ile Gln His Ser Leu Ile 
    850                 855                 860                 


Gln Gln Tyr Glu Tyr Asp Arg Asp Tyr Gly Arg Lys Gly Ala Pro Val 
865                 870                 875                 880 


Val Ser Glu Arg Val Leu Gln Leu Leu Glu Gln Cys Arg Glu His Ser 
                885                 890                 895     


Asn Tyr Ser Arg Asp Leu Leu His Ile Leu Asn Leu Pro Phe Gly Tyr 
            900                 905                 910         


Asn Leu Pro Arg Tyr Leu Asn Leu Ser Ser Glu Lys Tyr Phe Asp Ala 
        915                 920                 925             


Asn Ala Ile 
    930     


<210>  2885
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2885

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Asp Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Lys 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Leu Glu Asn Glu Ser Asn Asn Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe Thr Asp Pro 
    210                 215                 220                 


Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn Ile Lys Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu Tyr Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Ile Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Asp Asp Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Ile Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Arg Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2886
<211>  926
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2886

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Lys Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asn Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Asp Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Lys Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile Asn Lys 
225                 230                 235                 240 


Val Lys Gly Asn Ile Lys Lys Ser Phe Ser Thr Phe Asn Asp Leu Leu 
                245                 250                 255     


Lys Thr Lys Arg Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys 
            260                 265                 270         


Asp Thr Arg Val Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu 
        275                 280                 285             


Ala Ile Val Gly Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Ser 
    290                 295                 300                 


Lys Leu His Glu Asp Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu 
305                 310                 315                 320 


Tyr Arg Glu Thr Leu Asp Tyr Leu Val Asp Glu Arg Phe Glu Ser Ile 
                325                 330                 335     


Asn Lys Gly Phe Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile 
            340                 345                 350         


Asp Met Met Lys Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr 
        355                 360                 365             


Asp Phe Ile Val Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys 
    370                 375                 380                 


Lys Leu Arg Glu Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp 
385                 390                 395                 400 


Lys Gln Tyr Asp Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe 
                405                 410                 415     


Leu Leu Phe Cys Asn Tyr Tyr Arg Asn Asp Val Ile Ala Gly Glu Ala 
            420                 425                 430         


Leu Val Arg Lys Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly 
        435                 440                 445             


Ile Tyr Ala Asp Glu Ala Ser Lys Leu Trp Gly Lys Phe Arg Asn Asp 
    450                 455                 460                 


Phe Glu Asn Ile Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu 
465                 470                 475                 480 


Gly Lys Ala Asp Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys 
                485                 490                 495     


Lys Asn Ala Ser Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu 
            500                 505                 510         


Thr Tyr Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu 
        515                 520                 525             


Ile Ser Lys Phe Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser 
    530                 535                 540                 


Ser Ala Val Asp Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe 
545                 550                 555                 560 


Asn Asp Ser Gln Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile 
                565                 570                 575     


Ala Ser Met Arg Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg 
            580                 585                 590         


Asp Ala Leu Thr Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg 
        595                 600                 605             


Ile Ser Glu Ile Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly 
    610                 615                 620                 


Leu Arg Asn Phe Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val 
625                 630                 635                 640 


Tyr Leu Ile Lys Tyr Ala Asn Ala Gln Lys Ile Arg Lys Val Ala Glu 
                645                 650                 655     


Asn Glu Lys Val Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln 
            660                 665                 670         


Ile Glu Arg Tyr Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser 
        675                 680                 685             


Ser Leu Glu Val Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile 
    690                 695                 700                 


Ser Phe Asp Asp Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu 
705                 710                 715                 720 


Asn Val Ala Lys Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr 
                725                 730                 735     


Val Met Tyr Leu Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr 
            740                 745                 750         


Val Ile Ala Ile His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu 
        755                 760                 765             


Ile Ile Pro Glu Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile 
    770                 775                 780                 


Leu Ser Gln Thr Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe 
785                 790                 795                 800 


Leu Lys Lys Asn Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn 
                805                 810                 815     


Asn Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His 
            820                 825                 830         


Leu Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr 
        835                 840                 845             


Val Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile 
    850                 855                 860                 


Thr Lys Arg Glu Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu 
865                 870                 875                 880 


Asp Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala 
                885                 890                 895     


Leu Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser 
            900                 905                 910         


Ile Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925     


<210>  2887
<211>  921
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2887

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Phe Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Leu Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Leu Ser Glu His Ser Glu Tyr Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asp Asn Ser Lys Lys Val Tyr Arg Glu Cys Arg Glu Thr Leu 
305                 310                 315                 320 


Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile 
                325                 330                 335     


Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly 
            340                 345                 350         


Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu 
        355                 360                 365             


Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys 
    370                 375                 380                 


Ile Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser 
385                 390                 395                 400 


Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn 
                405                 410                 415     


Tyr Tyr Arg Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu 
            420                 425                 430         


Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu 
        435                 440                 445             


Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala 
    450                 455                 460                 


Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met 
465                 470                 475                 480 


Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp 
                485                 490                 495     


Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp 
            500                 505                 510         


Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp 
        515                 520                 525             


Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val 
    530                 535                 540                 


Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg 
545                 550                 555                 560 


Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys 
                565                 570                 575     


Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile 
            580                 585                 590         


Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Gly Ile Leu 
        595                 600                 605             


Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile 
    610                 615                 620                 


Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr 
625                 630                 635                 640 


Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val 
                645                 650                 655     


Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr 
            660                 665                 670         


Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Gly Val Lys 
        675                 680                 685             


Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe 
    690                 695                 700                 


Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu 
705                 710                 715                 720 


Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu 
                725                 730                 735     


Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His 
            740                 745                 750         


Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu 
        755                 760                 765             


Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu 
    770                 775                 780                 


Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu 
785                 790                 795                 800 


Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser 
                805                 810                 815     


Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg 
            820                 825                 830         


Glu Leu Lys Glu Tyr Ile Gly Asp Ile Cys Thr Val Asp Ser Tyr Phe 
        835                 840                 845             


Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn 
    850                 855                 860                 


Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys 
865                 870                 875                 880 


Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe 
                885                 890                 895     


Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe 
            900                 905                 910         


Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920     


<210>  2888
<211>  954
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2888

Met Thr Lys Pro Glu Lys Lys Gln Ile Lys Gln Ala Thr Leu Thr Lys 
1               5                   10                  15      


Arg Met Gly Leu Lys Ser Thr Leu Val Phe Asp Asn Lys Ile Thr Val 
            20                  25                  30          


Thr Ser Phe Ala Asn Ser Ser Asn Ser Glu Lys Ala Ser Ala His Ile 
        35                  40                  45              


Glu Lys Arg Thr Asp Phe Trp Gly Lys Thr Ile Met Gln Asp Glu Lys 
    50                  55                  60                  


Met Phe Arg Thr Asp Val Glu Lys Gln Gln Ile Tyr Ile Glu Lys Glu 
65                  70                  75                  80  


Phe Pro Asp Glu Asn Asn Lys Ile Ile Thr Gln Thr Ala Met Phe Glu 
                85                  90                  95      


Asn Pro Ala Leu Arg Asn Cys Gly Lys Asp Tyr Ile Gly Met Lys Asn 
            100                 105                 110         


Ser Val Glu Lys Val Met Phe Gly Lys Glu Phe Pro Asn Asp Asn Leu 
        115                 120                 125             


His Ile Gln Ile Ala Tyr Asn Ile Leu Asp Ile Lys Lys Ile Ile Cys 
    130                 135                 140                 


Pro Tyr Ile Asn Asn Val Val Asn Ile Phe Tyr Asn Leu Gly Arg Gly 
145                 150                 155                 160 


Lys Leu Lys Asp Asp Lys Asn Asp Leu Leu Gly Asn Lys Ile Gly Leu 
                165                 170                 175     


Lys Ser Glu Glu Lys Ile Glu Asp Leu Leu Ile Asn Ser Ser Ala Tyr 
            180                 185                 190         


Phe Val Tyr Phe Gly Asp Val Phe Lys Gln Val Lys Leu Ser Lys Glu 
        195                 200                 205             


Gln Gln Glu Lys Ser Glu Glu Glu Lys Arg Arg Ile Trp Gln Glu Leu 
    210                 215                 220                 


Trp Asn Lys Asn Phe Asp His Asn Lys Asn Ile Val Asn Ser Leu Ile 
225                 230                 235                 240 


Lys Phe Arg Gln Met Cys Phe His Gln Asn Tyr Glu Asn Ser Asp Lys 
                245                 250                 255     


Glu Val Ser Ser Thr Ala Leu Phe Asn Ile Glu Gln Phe Leu Asn Lys 
            260                 265                 270         


Glu Glu Lys Ala Ser Leu Asp Glu Ile Tyr Thr Gly Ala Ile Asp Lys 
        275                 280                 285             


Val Asn Tyr Asp Phe Asn Lys Asn Ser Ser Asn Asn Leu Tyr Ile Leu 
    290                 295                 300                 


Glu Gln Ile Tyr Cys Asn Asp Lys Asn Leu Gly Gln Arg Tyr Tyr Asp 
305                 310                 315                 320 


Phe Val Val Lys Lys Ser Gln Cys Asn Leu Gly Leu Asp Thr Lys Leu 
                325                 330                 335     


Ile Arg Glu Leu Leu Ile Arg Lys Leu Ser Asp Glu Gly Leu Asp Ile 
            340                 345                 350         


Asn Asp Ser Arg Tyr Asp Thr Tyr Arg Asn Lys Ile Tyr Thr Val Phe 
        355                 360                 365             


Gly Phe Ile Leu Tyr Tyr Glu Leu Thr Lys Asn Glu Thr Phe Cys Gln 
    370                 375                 380                 


Glu Ile Val Ala Lys Leu Arg Arg Phe Gly Gly Asp Glu Ile Glu Lys 
385                 390                 395                 400 


Asn Lys Ile Tyr Asn Glu Tyr Phe Leu Arg Lys Glu Ala Val Tyr Asn 
                405                 410                 415     


Gln Ile Ala Glu Lys Phe Lys Gln Ser Val Cys Trp Phe Lys Lys Glu 
            420                 425                 430         


Lys Glu Lys Lys Lys Glu Phe Ser Ser Lys Thr Lys Ile Asp Leu Lys 
        435                 440                 445             


Ser Val Gln Lys Ile Glu Asp Gln Asn Ala Ser Val Phe Ala Lys Met 
    450                 455                 460                 


Val Tyr Leu Ile Ser Arg Phe Leu Asp Gly Lys Glu Ile Asn Glu Leu 
465                 470                 475                 480 


Cys Thr Lys Leu Leu Asn Lys Phe Lys Asn Ile Asn Glu Leu Val Glu 
                485                 490                 495     


Thr Ala Lys Arg Cys Gly Glu Thr Ile Glu Phe Cys Pro Glu Tyr Lys 
            500                 505                 510         


Met Phe Lys Asn Ser Ala Lys Leu Ala Glu Glu Met Arg Phe Val Gln 
        515                 520                 525             


Ser Val Ser Lys Met Lys Lys Leu Thr Lys Lys Glu Asp Lys Ser Ile 
    530                 535                 540                 


Lys Pro Gln Val Ile Asp Asp Ala Leu Glu Leu Leu Gly Leu Lys Ile 
545                 550                 555                 560 


Glu Lys Tyr Lys Lys Asp Asp Gln Gly Asn Phe Val Leu Asp Asp Gln 
                565                 570                 575     


Asn His Asn Val Trp Thr Asp Glu Tyr Lys Ser Tyr Arg Lys Glu Tyr 
            580                 585                 590         


Phe Thr Pro Lys Asn Ser Asp Ser Met Asn Asp Ala Glu Lys Ser Phe 
        595                 600                 605             


Val Ala Lys Gly His Gln Lys Arg Asn Phe Ile Ile Ser Asn Val Val 
    610                 615                 620                 


Leu Asn Lys Arg Phe Leu Tyr Val Ala Lys Tyr Gly Ser Pro Thr Ala 
625                 630                 635                 640 


Cys Asn Gln Met Met Lys Asn Gln Lys Ile Val Arg Met Ala Leu Glu 
                645                 650                 655     


Ser Ile Ser Glu Asp Gln Leu Arg Lys Tyr Ala Arg Arg Val Tyr Asp 
            660                 665                 670         


Asn Lys Glu His Phe Gln Asn Gln Thr Ala Asp Glu Ile Arg Glu Asn 
        675                 680                 685             


Leu Ala Lys Lys Leu Lys Asn Phe Asn Ile Gly Ala Glu Leu Lys Thr 
    690                 695                 700                 


Val Gly Asn Leu Ser Lys Lys Asp Phe Cys Ser Ser Lys Asn Thr Val 
705                 710                 715                 720 


Lys Asp Lys Ser Lys Ser Leu Ile Gly Leu Tyr Leu Thr Val Ala Tyr 
                725                 730                 735     


Leu Ile Thr Lys Asn Met Ile Lys Ile Asn Thr Arg Phe Ser Ile Ala 
            740                 745                 750         


Phe Gly Ala Tyr Glu Arg Asp Met Glu Phe Leu Leu Gln Gln Lys Lys 
        755                 760                 765             


Glu Lys Gly Asn Arg Phe Asp Trp Leu Ala Leu Thr Gln Lys Phe Leu 
    770                 775                 780                 


Ser Glu Asp Lys Asn Tyr Tyr Phe Glu His Asp Leu Arg Arg Lys Glu 
785                 790                 795                 800 


Ile Asn Lys Ile Ser Asp Arg Asp Glu Arg Lys Lys Gln His Arg Glu 
                805                 810                 815     


Asn Asp Lys Tyr Tyr Asp Ser Arg Met His Phe Ser Arg His Ser Phe 
            820                 825                 830         


Glu Tyr Ile Ser Lys Asn Phe Ala Glu Val Gln Ser His Pro Asp Pro 
        835                 840                 845             


Leu Lys Leu Phe Ile Lys Tyr Arg Asn Asn Val Met His Leu Asn Ile 
    850                 855                 860                 


Ile Arg Asp Leu Asn Asp Tyr Leu Pro Asp Phe Lys Arg Gly Lys Ala 
865                 870                 875                 880 


Phe Glu Lys Thr Asp Thr Phe Tyr Asp Leu Tyr Cys Tyr Cys Leu Gln 
                885                 890                 895     


Lys Met Leu Leu Ser Glu Val Asp Gly Phe Ser Ala Ile Asn Glu Asn 
            900                 905                 910         


Ile Asp Lys Tyr Cys Thr Ala Ser Lys Asp Phe Met Asn Leu Leu Asn 
        915                 920                 925             


Ile Ile Phe Ala Tyr Asn Val Pro Arg Tyr Lys Asn Leu Ser Asn Lys 
    930                 935                 940                 


Glu Leu Phe Tyr Arg Leu Asp Ser Glu Gln 
945                 950                 


<210>  2889
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2889

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Glu Ser Ser Ser Asn Ile Glu Leu Cys Gly 
            100                 105                 110         


Val Thr Lys Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Gln Asn Thr Tyr Tyr Ile 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe 
    290                 295                 300                 


Asp Ile Tyr Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Ile Ala Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Ala Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asp Asp Lys Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  2890
<211>  956
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2890

Met Ala Lys Lys Lys Arg Ile Thr Ala Lys Glu Arg Lys Gln Asn His 
1               5                   10                  15      


Arg Glu Ser Leu Met Lys Lys Ala Asp Ser Asn Ala Glu Lys Glu Lys 
            20                  25                  30          


Ala Lys Lys Pro Val Val Glu Asn Lys Pro Asp Thr Ala Ile Ser Lys 
        35                  40                  45              


Asp Asn Thr Pro Lys Pro Asn Lys Glu Ile Lys Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Ala Gly Val Lys Trp Val Ile Lys Ala Asn Asp Asp Val Ala Tyr 
65                  70                  75                  80  


Ile Ser Ser Phe Gly Lys Gly Asn Asn Ser Val Leu Glu Lys Arg Ile 
                85                  90                  95      


Ile Gly Asp Val Ser Ser Asp Val Asn Lys Asp Ser His Met Tyr Val 
            100                 105                 110         


Asn Pro Lys Tyr Thr Lys Lys Asn Tyr Glu Ile Lys Asn Gly Phe Ser 
        115                 120                 125             


Ser Gly Ser Ser Leu Thr Thr His Pro Asn Lys Pro Asp Lys Asn Ser 
    130                 135                 140                 


Gly Met Asp Ala Leu Cys Leu Lys Ile Tyr Phe Glu Lys Glu Ile Phe 
145                 150                 155                 160 


Lys Asp Lys Phe Asn Asp Asn Met His Ile Gln Thr Ile Tyr Asn Ile 
                165                 170                 175     


Phe Asp Ile Glu Lys Thr Leu Ala Lys His Ile Thr Asn Ile Ile Tyr 
            180                 185                 190         


Ala Val Asn Ser Leu Asp Arg Ser Tyr Ile Gln Ser Gly Asn Asp Thr 
        195                 200                 205             


Ile Gly Phe Gly Leu Asn Tyr Arg Ile Pro Tyr Ala Lys Tyr Gly Arg 
    210                 215                 220                 


Gly Lys Asp Ser Asn Gly Lys Pro Asn Asn Ser Asn Leu Lys Lys Arg 
225                 230                 235                 240 


Glu Ser Phe Ile Lys Phe Tyr Asn Asn Ala Lys Asp Arg Phe Gly Tyr 
                245                 250                 255     


Phe Glu Ser Val Phe Tyr Gln Asn Gly Lys Pro Ile Ser Arg Glu Lys 
            260                 265                 270         


Leu Tyr Ile Tyr Leu Asn Ile Leu Asn Phe Val Arg Asn Ser Thr Phe 
        275                 280                 285             


His Tyr Asn Asn Thr Ser Thr Tyr Leu Tyr Arg Lys Glu Tyr Lys Tyr 
    290                 295                 300                 


Thr Asp Lys Asp Asn Cys Ser Val Lys Glu Phe Glu Phe Val Ser Tyr 
305                 310                 315                 320 


Leu Asn Glu Phe Val Lys Asn Lys Phe Lys Asn Val Asn Lys Asn Phe 
                325                 330                 335     


Ile Ser Asn Glu Lys Asn Asn Leu Tyr Ile Ile Leu Asn Ala Tyr Gly 
            340                 345                 350         


Glu Asp Ile Glu Asp Val Glu Val Val Lys Lys Tyr Ser Lys Glu Leu 
        355                 360                 365             


Tyr Lys Leu Ser Val Leu Lys Thr Asn Lys Asn Leu Gly Val Asn Val 
    370                 375                 380                 


Lys Lys Leu Arg Glu Ser Ala Ile Glu Tyr Gly Tyr Cys Pro Leu Pro 
385                 390                 395                 400 


Tyr Asp Lys Glu Lys Glu Val Ala Lys Leu Ser Ser Ile Lys His Lys 
                405                 410                 415     


Leu Tyr Lys Thr Tyr Asp Phe Val Ile Thr His Tyr Leu Asn Ser Asn 
            420                 425                 430         


Asp Lys Leu Leu Leu Glu Ile Val Glu Ala Leu Arg Leu Ser Lys Asn 
        435                 440                 445             


Asp Asp Glu Lys Glu Asn Val Tyr Lys Ile Tyr Ala Glu Lys Ile Phe 
    450                 455                 460                 


Lys Ala Glu Tyr Val Ile Asn Pro Ile Lys Thr Ile Ser Asn Leu Phe 
465                 470                 475                 480 


Ala Glu Lys Gly Asp Lys Leu Phe Asn Glu Lys Val Ser Ile Ser Glu 
                485                 490                 495     


Glu Tyr Val Glu Asp Ile Arg Ile Asp Lys Asn Ile His Asn Phe Thr 
            500                 505                 510         


Lys Val Ile Phe Phe Leu Thr Cys Phe Leu Asp Gly Lys Glu Ile Asn 
        515                 520                 525             


Asp Leu Leu Thr Asn Ile Ile Ser Lys Leu Gln Val Ile Glu Asp His 
    530                 535                 540                 


Asn Asn Val Ile Lys Ala Ile Ala Asn Asn Asn Asp Ala Val Tyr Lys 
545                 550                 555                 560 


Asp Tyr Ser Asp Lys Tyr Ala Val Phe Lys Asn Ser Gly Lys Ile Ala 
                565                 570                 575     


Thr Lys Leu Glu Ala Ile Lys Ser Ile Ala Arg Met Glu Asn Lys Ile 
            580                 585                 590         


Asn Lys Ala Phe Lys Glu Pro Leu Leu Lys Asp Ala Met Leu Ala Leu 
        595                 600                 605             


Gly Val Ser Pro Asn Asp Leu Asp Glu Lys Tyr Glu Lys Tyr Phe Lys 
    610                 615                 620                 


Thr Asp Val Asp Ala Asp Lys Asp His Gln Lys Val Ser Thr Phe Leu 
625                 630                 635                 640 


Met Asn Asn Val Ile Asn Asn Ser Arg Phe Lys Tyr Val Val Lys Tyr 
                645                 650                 655     


Ile Asn Pro Ala Asp Ile Asn Arg Leu Ala Lys Asn Lys His Leu Val 
            660                 665                 670         


Lys Phe Val Leu Asp Gln Ile Pro His Lys Gln Ile Asp Ser Tyr Tyr 
        675                 680                 685             


Asn Ser Val Cys Thr Val Glu Glu Pro Ser Tyr Lys Gly Lys Ile Gln 
    690                 695                 700                 


Leu Leu Thr Lys Lys Ile Thr Gly Leu Asn Phe Tyr Ser Leu Phe Glu 
705                 710                 715                 720 


Asn Cys Lys Ile Pro Asn Val Glu Lys Glu Lys Lys Lys Ala Val Ile 
                725                 730                 735     


Thr Leu Tyr Phe Thr Ile Ile Tyr Ile Leu Val Lys Asn Leu Val Asn 
            740                 745                 750         


Ile Asn Gly Leu Tyr Thr Leu Ala Leu Tyr Phe Val Glu Arg Asp Gly 
        755                 760                 765             


Phe Phe Tyr Lys Lys Ile Cys Glu Lys Lys Asp Lys Lys Lys Thr Asn 
    770                 775                 780                 


Lys Asp Val Asp Tyr Leu Leu Leu Pro Glu Ile Phe Ser Gly Ser Lys 
785                 790                 795                 800 


Tyr Arg Glu Glu Thr Lys Asn Leu Lys Leu Pro Lys Glu Lys Asp Arg 
                805                 810                 815     


Glu Ile Met Lys Lys Tyr Leu Pro Asn Asp Glu Asp Arg Lys Glu Tyr 
            820                 825                 830         


Asn Lys Phe Phe Lys Gln Tyr Arg Asn Asn Ile Val His Leu Asn Ile 
        835                 840                 845             


Ile Ala Asn Leu Ser Lys Leu Thr Ser Thr Ile Asp Lys Glu Ile Asn 
    850                 855                 860                 


Ser Tyr Phe Glu Ile Phe His Tyr Cys Ala Gln Arg Val Met Phe Asp 
865                 870                 875                 880 


Tyr Cys Lys Asn Asn Asn Lys Val Val Leu Ala Lys Met Lys Asp Leu 
                885                 890                 895     


Ala His Ile Lys Ser Asp Cys Asp Glu Phe Ser Ser Lys Tyr Thr Tyr 
            900                 905                 910         


Pro Tyr Ser Ser Ala Val Leu Arg Phe Met Asn Leu Pro Phe Ala Tyr 
        915                 920                 925             


Asn Val Pro Arg Phe Lys Asn Leu Ser Tyr Gln Lys Phe Phe Asp Lys 
    930                 935                 940                 


Gln Arg Leu Glu Ala Leu Glu Lys Asn Leu Asn Ile 
945                 950                 955     


<210>  2891
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2891

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Ile Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Pro Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn His Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Met Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2892
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2892

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Val Ala Glu Val Ile Ala Pro Thr Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Asp Gly Ser Ser Asn Ile Glu Leu Arg Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Asp Glu Ser His Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe Thr Asp 
    210                 215                 220                 


Pro Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Asn Ala Leu Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu Glu Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Pro Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp Asp Ile 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  2893
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2893

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Phe 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Glu Asp Ser Ser Asn Ile Glu Leu Cys Gly Val Thr Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Leu Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Lys Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Ala Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Lys Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Lys 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Ile Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Glu 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Gln Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Ser Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Val Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asp Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp Asp Thr 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  2894
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2894

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Asp Gly Ser Ser Asn Ile Glu Leu Arg Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Gln Asn Thr Tyr Tyr Ile Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu Tyr Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Val Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Glu 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Pro Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp Asp Ile 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  2895
<211>  926
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2895

Met Leu Leu Cys Ala Ile Ile Gln Ala Ser Thr Lys Arg Asp Arg Lys 
1               5                   10                  15      


Gly Gly Val Arg Met Glu Arg Glu Val Lys Lys Pro Pro Lys Lys Ser 
            20                  25                  30          


Leu Ala Lys Ala Ala Gly Leu Lys Ser Thr Phe Val Ile Ser Pro Gln 
        35                  40                  45              


Glu Lys Glu Leu Ala Met Thr Ala Phe Gly Arg Gly Asn Asp Ala Leu 
    50                  55                  60                  


Leu Gln Lys Arg Ile Val Asp Gly Val Val Arg Asp Val Ala Gly Glu 
65                  70                  75                  80  


Lys Gln Gln Phe Gln Val Gln Arg Gln Asp Glu Ser Arg Phe Arg Val 
                85                  90                  95      


Gln Asn Ser Arg Leu Ala Asp Arg Thr Val Thr Ala Asp Asp Pro Leu 
            100                 105                 110         


His Arg Ala Glu Thr Pro Arg Arg Gln Pro Leu Gly Ala Gly Met Asp 
        115                 120                 125             


Gln Leu Arg Arg Lys Ala Ile Leu Glu Gln Lys Tyr Phe Gly Arg Thr 
    130                 135                 140                 


Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile 
145                 150                 155                 160 


His Lys Met Leu Ala Val Pro Ala Asn His Ile Val His Thr Leu Asn 
                165                 170                 175     


Leu Leu Gly Gly Tyr Gly Glu Thr Asp Phe Val Gly Met Leu Pro Ala 
            180                 185                 190         


Gly Leu Pro Tyr Asp Lys Leu Arg Val Val Lys Lys Lys Asn Gly Asp 
        195                 200                 205             


Thr Val Asp Ile Lys Ala Asp Ile Ala Ala Tyr Ala Lys Arg Pro Gln 
    210                 215                 220                 


Leu Ala Tyr Leu Gly Ala Ala Phe Tyr Asp Val Thr Pro Gly Lys Ser 
225                 230                 235                 240 


Lys Arg Asp Ala Ala Arg Gly Arg Val Lys Arg Glu Gln Asp Val Tyr 
                245                 250                 255     


Thr Ile Leu Ser Leu Met Ser Leu Leu Arg Gln Phe Cys Ala His Asp 
            260                 265                 270         


Ser Val Arg Ile Trp Gly Gln Asn Thr Pro Ala Ala Leu Tyr Gly Leu 
        275                 280                 285             


Gln Ala Leu Pro Gln Asp Met Lys Asp Leu Leu Asp Asp Gly Trp Arg 
    290                 295                 300                 


Arg Ala Leu Gly Gly Val Asn Asp His Phe Leu Asp Thr Asn Lys Val 
305                 310                 315                 320 


Asn Leu Leu Thr Leu Phe Glu Tyr Tyr Gly Ala Glu Thr Lys Gln Glu 
                325                 330                 335     


Arg Val Ala Leu Thr Gln Asp Phe Tyr Arg Phe Val Val Leu Lys Glu 
            340                 345                 350         


Gln Lys Asn Met Gly Phe Ser Leu Arg Arg Leu Arg Glu Glu Leu Leu 
        355                 360                 365             


Lys Leu Pro Asp Ala Ala Tyr Leu Thr Gly Gln Glu Tyr Asp Ser Val 
    370                 375                 380                 


Arg Gln Lys Leu Tyr Met Leu Leu Asp Phe Leu Leu Cys Arg Leu Tyr 
385                 390                 395                 400 


Ala Gln Glu Arg Ala Gly Arg Cys Glu Glu Leu Val Ser Ala Leu Arg 
                405                 410                 415     


Cys Ala Leu Ser Asp Glu Glu Lys Asp Thr Val Tyr Gln Ala Glu Ala 
            420                 425                 430         


Ala Ala Leu Trp Gln Ala Leu Gly Asp Thr Leu Arg Arg Glu Leu Leu 
        435                 440                 445             


Pro Leu Leu Lys Gly Lys Lys Leu Gln Asp Lys Asp Lys Lys Lys Pro 
    450                 455                 460                 


Asp Glu Leu Gly Leu Ser Arg Asp Val Leu Asp Gly Val Leu Phe Arg 
465                 470                 475                 480 


Pro Ala Gln Gln Gly Asn Arg Ala Asn Ala Asp Tyr Phe Cys Arg Leu 
                485                 490                 495     


Met His Leu Ser Thr Trp Phe Met Asp Gly Lys Glu Ile Asn Thr Leu 
            500                 505                 510         


Leu Thr Thr Leu Ile Ser Lys Leu Glu Asn Ile Asp Ser Leu Arg Asn 
        515                 520                 525             


Val Leu Glu Ser Met Gly Leu Ala Cys Ser Phe Val Pro Ala Tyr Ala 
    530                 535                 540                 


Met Phe Asp His Ser Arg Tyr Ile Ala Gly Gln Leu Arg Val Val Asn 
545                 550                 555                 560 


Asn Ile Ala Arg Met Arg Lys Pro Ala Ile Thr Ala Lys Arg Glu Met 
                565                 570                 575     


Tyr Arg Ala Ala Val Val Leu Leu Gly Val Asp Ser Pro Glu Ala Ala 
            580                 585                 590         


Ala Ala Ile Thr Asp Asp Leu Leu Gln Ile Asp Pro Glu Thr Gly Lys 
        595                 600                 605             


Val Arg Pro Arg Ser Asp Ser Ala Arg Asp Thr Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Ala Asn Asn Val Val Glu Ser Arg Arg Phe Thr Tyr Leu Leu Arg 
625                 630                 635                 640 


Tyr Met Thr Pro Glu Gln Ala Arg Val Leu Ala Gln Asn Glu Lys Leu 
                645                 650                 655     


Ile Ala Phe Val Leu Ser Thr Val Pro Asp Thr Gln Leu Glu Arg Tyr 
            660                 665                 670         


Cys Arg Thr Cys Gly Arg Glu Asp Ile Thr Gly Arg Pro Ala Gln Ile 
        675                 680                 685             


Arg Tyr Leu Thr Ala Gln Ile Met Gly Val Arg Tyr Glu Ser Phe Thr 
    690                 695                 700                 


Asp Val Glu Gln Arg Gly Arg Gly Asp Asn Pro Arg Lys Glu Arg Tyr 
705                 710                 715                 720 


Lys Ala Leu Ile Gly Leu Tyr Leu Thr Val Leu Tyr Leu Ala Val Lys 
                725                 730                 735     


Asn Met Val Asn Cys Asn Ala Arg Tyr Val Ile Ala Phe Tyr Cys Arg 
            740                 745                 750         


Asp Arg Asp Thr Ala Leu Tyr Gln Lys Glu Val Cys Trp Tyr Asp Leu 
        755                 760                 765             


Glu Glu Asp Lys Lys Ser Gly Lys Gln Arg Gln Val Glu Asp Tyr Thr 
    770                 775                 780                 


Ala Leu Thr Arg Tyr Phe Val Ser Gln Gly Tyr Leu Asn Arg His Ala 
785                 790                 795                 800 


Cys Gly Tyr Leu Arg Ser Asn Met Asn Gly Ile Ser Asn Gly Leu Leu 
                805                 810                 815     


Thr Ala Tyr Arg Asn Ala Val Asp His Leu Asn Ala Ile Pro Pro Leu 
            820                 825                 830         


Gly Ser Leu Cys Arg Asp Ile Gly Arg Val Asp Ser Tyr Phe Ala Leu 
        835                 840                 845             


Tyr His Tyr Ala Val Gln Gln Tyr Leu Asn Gly Arg Tyr Tyr Arg Lys 
    850                 855                 860                 


Thr Pro Arg Glu Gln Glu Leu Phe Ala Ala Met Ala Gln His Arg Thr 
865                 870                 875                 880 


Trp Cys Ser Asp Leu Val Lys Ala Leu Asn Thr Pro Phe Gly Tyr Asn 
                885                 890                 895     


Leu Ala Arg Tyr Lys Asn Leu Ser Ile Asp Gly Leu Phe Asp Arg Glu 
            900                 905                 910         


Gly Asp His Val Val Arg Glu Asp Gly Glu Lys Pro Ala Glu 
        915                 920                 925     


<210>  2896
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2896

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asp Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Val Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Ile Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Asn Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2897
<211>  918
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2897

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asn Asn Ile Tyr Pro Glu Tyr Arg Asp Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp 
    370                 375                 380                 


Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Val Val Ala Gly Glu Ser Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Gly Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ser 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Lys Val Ala Lys Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu Arg 
785                 790                 795                 800 


Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr Arg 
                805                 810                 815     


Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu Lys 
            820                 825                 830         


Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile Tyr 
        835                 840                 845             


His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp Asp Thr Lys 
    850                 855                 860                 


Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His Gly 
865                 870                 875                 880 


Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr Asn 
                885                 890                 895     


Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg Asn 
            900                 905                 910         


Glu Tyr Leu Thr Glu Lys 
        915             


<210>  2898
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2898

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asp Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Asn Arg Val Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asn Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Glu Arg Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2899
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2899

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Ile Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Ile Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Asn Arg Val Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu His Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Ile Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Glu 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Pro Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp Asp Ile 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  2900
<211>  954
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2900

Met Gly Lys Lys Ile His Ala Arg Asp Leu Arg Glu Gln Arg Lys Thr 
1               5                   10                  15      


Asp Arg Thr Glu Lys Phe Ala Asp Gln Asn Lys Lys Arg Glu Ala Glu 
            20                  25                  30          


Arg Ala Val Gln Lys Lys Asp Ala Ala Val Ser Val Lys Ser Val Ser 
        35                  40                  45              


Ser Val Ser Ser Lys Lys Asp Asn Val Thr Lys Ser Met Ala Lys Ala 
    50                  55                  60                  


Ala Gly Val Lys Ser Val Phe Ala Val Glu Asn Thr Val Tyr Met Thr 
65                  70                  75                  80  


Ser Phe Gly Arg Gly Asn Asp Ala Val Leu Glu Gln Lys Ile Val Asp 
                85                  90                  95      


Thr Ser His Glu Gln Leu Asn Ile Asp Asp Pro Ala Tyr Gln Leu Asn 
            100                 105                 110         


Val Val Thr Met Asn Gly Tyr Ser Val Thr Gly His Arg Gly Glu Thr 
        115                 120                 125             


Val Ser Ala Val Thr Asp Asn Pro Leu Arg Arg Phe Asn Gly Gly Lys 
    130                 135                 140                 


Lys Asp Glu Pro Glu Gln Ser Val Pro Thr Asp Met Leu Cys Leu Lys 
145                 150                 155                 160 


Pro Thr Leu Glu Lys Lys Phe Phe Gly Lys Glu Phe Asn Asp Asn Ile 
                165                 170                 175     


His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala 
            180                 185                 190         


Val Tyr Ser Thr Asn Ala Ile Tyr Ala Leu Asn Asn Met Ser Ala Asp 
        195                 200                 205             


Glu Asn Ile Glu Asn Ser Asp Phe Phe Met Lys Arg Thr Thr Asp Glu 
    210                 215                 220                 


Thr Phe Asp Asp Phe Glu Lys Lys Lys Glu Ser Thr Asn Ser Arg Glu 
225                 230                 235                 240 


Lys Ala Asp Phe Asp Ala Phe Glu Lys Phe Ile Gly Asn Tyr Arg Leu 
                245                 250                 255     


Ala Tyr Phe Ala Asp Ala Phe Tyr Val Asn Lys Lys Asn Pro Lys Gly 
            260                 265                 270         


Lys Ala Arg Asn Val Leu Arg Glu Asp Lys Glu Leu Tyr Ser Val Leu 
        275                 280                 285             


Thr Leu Ile Gly Lys Leu Arg His Trp Cys Val His Ser Glu Glu Gly 
    290                 295                 300                 


Arg Ala Glu Phe Trp Leu Tyr Lys Leu Asn Glu Leu Lys Asp Asp Phe 
305                 310                 315                 320 


Lys Asn Val Leu Asp Val Val Tyr Asn Arg Pro Val Glu Glu Ile Asn 
                325                 330                 335     


Asn Arg Phe Ile Glu Asn Asn Lys Val Asn Ile Gln Ile Leu Gly Ser 
            340                 345                 350         


Val Tyr Lys Asn Thr Asp Ile Ala Glu Leu Val Arg Ser Tyr Tyr Glu 
        355                 360                 365             


Phe Leu Ile Thr Lys Lys Tyr Lys Asn Met Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Ser Met Leu Glu Gly Lys Gly Tyr Ala Asp Lys Glu Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Asn Lys Leu Tyr Gln Met Thr Asp Phe Ile Leu Tyr 
                405                 410                 415     


Thr Gly Tyr Ile Asn Glu Asp Ser Asp Arg Ala Asp Asp Leu Val Asn 
            420                 425                 430         


Thr Leu Arg Ser Ser Leu Lys Glu Asp Asp Lys Thr Thr Val Tyr Cys 
        435                 440                 445             


Lys Glu Ala Asp Tyr Leu Trp Lys Lys Tyr Arg Glu Ser Ile Arg Glu 
    450                 455                 460                 


Val Ala Asp Ala Leu Asp Gly Asp Asn Ile Lys Arg Leu Ser Lys Ser 
465                 470                 475                 480 


Asn Ile Glu Ile Gln Glu Asp Lys Leu Arg Lys Cys Phe Ile Ser Tyr 
                485                 490                 495     


Ala Asp Ser Val Ser Glu Phe Thr Lys Leu Ile Tyr Leu Leu Thr Arg 
            500                 505                 510         


Phe Leu Ser Gly Lys Glu Ile Asn Asp Leu Val Thr Thr Leu Ile Asn 
        515                 520                 525             


Lys Phe Asp Asn Ile Arg Ser Phe Leu Glu Ile Met Asp Glu Leu Gly 
    530                 535                 540                 


Leu Asp Arg Thr Phe Thr Ala Glu Tyr Ser Phe Phe Glu Asp Ser Thr 
545                 550                 555                 560 


Lys Tyr Leu Ala Glu Leu Val Glu Leu Asn Ser Phe Val Lys Ser Cys 
                565                 570                 575     


Ser Phe Asp Ile Asn Ala Lys Arg Thr Met Tyr Arg Asp Ala Leu Asp 
            580                 585                 590         


Ile Leu Gly Ile Lys Ser Gly Lys Thr Glu Glu Asp Ile Glu Lys Met 
        595                 600                 605             


Ile Asp Asn Ile Leu Gln Ile Asp Ala Asn Gly Asp Lys Lys Leu Lys 
    610                 615                 620                 


Lys Asn Asn Gly Leu Arg Asn Phe Ile Ala Ser Asn Val Ile Asp Ser 
625                 630                 635                 640 


Asn Arg Phe Lys Tyr Leu Val Arg Tyr Gly Asn Pro Lys Lys Ile Arg 
                645                 650                 655     


Glu Thr Ala Lys Cys Lys Pro Ala Val Arg Phe Val Leu Asn Glu Ile 
            660                 665                 670         


Pro Asp Ala Gln Ile Glu Arg Tyr Tyr Glu Ala Cys Cys Pro Glu Asn 
        675                 680                 685             


Thr Ala Leu Cys Ser Ala Asn Lys Lys Arg Glu Lys Leu Ala Asp Met 
    690                 695                 700                 


Ile Ala Glu Ile Glu Phe Glu Asn Phe Ser Asp Ala Gly Asn Tyr Gln 
705                 710                 715                 720 


Lys Ala Asn Val Thr Ser Lys Thr His Glu Ala Glu Ile Lys Arg Lys 
                725                 730                 735     


Asn Gln Ser Ile Ile Arg Leu Tyr Leu Thr Val Met Tyr Ile Met Leu 
            740                 745                 750         


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Phe His Cys 
        755                 760                 765             


Val Glu Arg Asp Thr Lys Leu Tyr Ala Glu Ser Gly Leu Glu Val Gly 
    770                 775                 780                 


Asn Ile Glu Lys Asn Lys Thr Asn Leu Thr Met Ala Val Met Gly Val 
785                 790                 795                 800 


Lys Leu Glu Asn Gly Ile Ile Lys Thr Glu Phe Asp Lys Ser Phe Ala 
                805                 810                 815     


Glu Asn Ala Ala Asn Arg Tyr Leu Arg Asn Ala Arg Trp Tyr Lys Leu 
            820                 825                 830         


Ile Leu Asp Asn Leu Lys Lys Ser Glu Arg Ala Val Val Asn Glu Phe 
        835                 840                 845             


Arg Asn Thr Val Cys His Leu Asn Ala Ile Arg Asn Ile Asn Ile Asn 
    850                 855                 860                 


Ile Asp Gly Ile Lys Glu Val Glu Asn Tyr Phe Ala Leu Tyr His Tyr 
865                 870                 875                 880 


Leu Ile Gln Lys His Leu Glu Asn Arg Phe Ala Asp Lys Lys Val Glu 
                885                 890                 895     


Arg Asp Thr Gly Asp Phe Ile Ser Lys Leu Glu Glu His Lys Thr Tyr 
            900                 905                 910         


Cys Lys Asp Phe Val Lys Ala Tyr Cys Thr Pro Phe Gly Tyr Asn Leu 
        915                 920                 925             


Val Arg Tyr Lys Asn Leu Thr Ile Asp Gly Leu Phe Asp Lys Asn Tyr 
    930                 935                 940                 


Pro Gly Lys Asp Asp Ser Asp Lys Gln Lys 
945                 950                 


<210>  2901
<211>  960
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2901

Met Ala Lys Lys Leu Asn Ala Lys Glu Lys Arg Leu Leu Ser Gln Gln 
1               5                   10                  15      


Ala Gln Lys Asp Lys Tyr Lys Lys Met Glu Glu Glu Arg Gln Ala Ala 
            20                  25                  30          


Glu Gln Ala Arg Leu Ala Glu Glu Ala Arg Gln Lys Ala Glu Thr Glu 
        35                  40                  45              


Arg Lys Lys Lys Glu Ala Leu Glu Lys Glu Ala Arg Glu Lys Leu Glu 
    50                  55                  60                  


Lys Glu Leu Leu Glu Lys Asn Pro Ser Leu Lys Lys Val Lys Lys Ser 
65                  70                  75                  80  


Lys Ala Lys Ala Ala Gly Leu Lys Ser Thr Phe Ala Ile Gly Asn Glu 
                85                  90                  95      


Leu Leu Met Thr Ser Phe Gly Lys Gly Asn Glu Ala Val Pro Glu His 
            100                 105                 110         


Tyr Ile Phe Glu Asn Gly Met Ile Ser Met Gln Asn Pro Pro Ala Phe 
        115                 120                 125             


Asp Val Glu Asn Arg Gly Thr Ser Phe Ser Ile Ala Gly Lys Asn Ala 
    130                 135                 140                 


Met Asn Ala Ile Ala Asp Asp Pro Arg Arg Thr Ser Lys Lys Val Ile 
145                 150                 155                 160 


Gly Glu Asp Leu Ile Gly Ala Lys Ser Ala Leu Glu Lys Arg Tyr Phe 
                165                 170                 175     


Gly Lys Thr Phe Glu Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
            180                 185                 190         


Leu Asp Ile Glu Lys Ile Leu Ser Lys His Ile Asn Asn Ile Val Phe 
        195                 200                 205             


Ser Ile Asn Asn Ile Arg Gly Ile Ala Asp Pro Glu Arg Asp Asp Leu 
    210                 215                 220                 


Ile Gly Tyr Met Ser Leu Arg Asp Ser Tyr Glu Tyr Phe Met Asp Glu 
225                 230                 235                 240 


Lys Asn Glu Lys Arg Lys Val Leu Arg Glu Ser Tyr Arg Lys Leu Phe 
                245                 250                 255     


Lys Ser Ser Arg Leu Ser Tyr Phe Gly Ser Ala Phe Tyr Val Glu Lys 
            260                 265                 270         


Gln Ser Thr Gln Lys Lys Lys Ser Gly Gln Lys Asn Phe Glu Leu Arg 
        275                 280                 285             


Asn Glu Lys Asp Cys Tyr Tyr Met Leu Ala Leu Leu Gly Glu Leu Arg 
    290                 295                 300                 


Gln Val Leu Ala His Ser Ser Ala Gln Lys Gln Gly Lys Glu Gln Thr 
305                 310                 315                 320 


Glu Ala Arg Ser Ser Val Tyr Asn Leu Arg Thr Val Gly Asn Asn Asp 
                325                 330                 335     


Met Arg Lys Ile Leu Asn Ser Leu Tyr Ala Glu Arg Val Asp Ala Leu 
            340                 345                 350         


Asn Glu Asn Phe Met Asn Tyr Ala Lys Lys Asp Leu Thr Ile Leu Phe 
        355                 360                 365             


Gly Ile Met Asp Ala Ser Ser Tyr Glu Lys Lys Ala Glu Ile Ala Arg 
    370                 375                 380                 


Asp Phe Tyr Asp Phe Thr Val Arg Lys Ser Tyr Lys Asn Ile Gly Phe 
385                 390                 395                 400 


Ser Ile Lys Lys Ile Arg Glu Arg Met Met Asp Cys Phe Phe Ala Asn 
                405                 410                 415     


Val Lys Glu Ile Thr Pro Asp Ser Pro Asp Phe Gln Ser Val Arg Gln 
            420                 425                 430         


Lys Phe Tyr Lys Ile Leu Asp Phe Leu Leu Phe Thr Tyr Tyr Lys Asp 
        435                 440                 445             


Asn Lys Glu Glu Thr Lys Lys Ile Ile Ala Ala Leu Arg Ala Ser Leu 
    450                 455                 460                 


Thr Glu Leu Glu Lys Glu Leu Phe Tyr Gln Lys Gln Ala Asn Ile Leu 
465                 470                 475                 480 


Trp Asn Lys Met Gln Met Val Val Thr Glu Gln Ile Tyr Pro Arg Thr 
                485                 490                 495     


Lys Gly Ser Ala Ile Gln Asn Leu Ile Ala Asp Pro Glu Ile Ser Ala 
            500                 505                 510         


Asp Met Leu Lys Gly Val Met Ile Thr Pro Glu Ser Val Asp Tyr Phe 
        515                 520                 525             


Ser Lys Met Ile Tyr Leu Leu Thr Leu Phe Ile Asp Gly Lys Glu Ile 
    530                 535                 540                 


Asn Asp Leu Leu Thr Thr Met Ile Asn Lys Phe Glu Asn Ile Ala Ser 
545                 550                 555                 560 


Phe Val Ser Val Leu Lys Asp Arg Gly Leu Pro Cys Asn Phe Arg Asn 
                565                 570                 575     


Asp Tyr Ser Val Phe Asn Asn Ala Leu Lys Ile Ser Ala Glu Leu Arg 
            580                 585                 590         


Glu Ile Asn Ser Phe Ala Arg Met Glu Lys Ala Thr Pro Gly Ala Lys 
        595                 600                 605             


Lys Gln Met Phe Leu Asp Ala Ala Ile Ile Leu Gly Ser Asn Glu Ser 
    610                 615                 620                 


Ala Glu Glu Leu Ser Glu Tyr Phe Asp Glu Met Leu Asp Lys Gln Lys 
625                 630                 635                 640 


Gly Lys Arg Thr Pro Gly Gly Lys Lys Asp Met Gly Phe Arg Asn Phe 
                645                 650                 655     


Leu Ile Lys Asn Val Ile Glu Ser Asp Arg Phe His Tyr Leu Ile Arg 
            660                 665                 670         


Tyr Gly His Pro Leu His Ile Ser Lys Leu Ala Glu Asn Lys Asn Val 
        675                 680                 685             


Ile Ala Phe Val Leu Lys Gln Ile Pro Glu Pro Gln Ile Asp Arg Tyr 
    690                 695                 700                 


Cys Lys Ile Cys Ala Leu Pro Ala Glu Ser Asn Phe Ala Gln Lys Ile 
705                 710                 715                 720 


Leu Arg Leu Thr Asp Leu Ile Ala Glu Met Asn Phe Arg Gln Phe Glu 
                725                 730                 735     


Asn Val Arg Gln Thr Glu Lys Asn Glu Gln Lys Gln Ile Leu Gln Gly 
            740                 745                 750         


Ile Leu Ser Leu Tyr Leu Thr Val Leu Tyr Leu Leu Thr Lys Asn Leu 
        755                 760                 765             


Val Tyr Val Asn Ser Arg Tyr Phe Leu Ala Phe His Cys Leu Glu Arg 
    770                 775                 780                 


Asp Thr Glu Leu Leu Gly Ser Gln Ala Gly His Lys Asn Ala Glu Lys 
785                 790                 795                 800 


Gln Leu Ile Ala Ser Tyr Ser Ala Leu Thr Gln Gln Phe Leu Asp Glu 
                805                 810                 815     


Gly Lys Leu Asn Arg His Ala Arg Glu Tyr Leu Thr Val Asn Ile Gln 
            820                 825                 830         


Asn Ser Asp Asp Trp Thr Ile Ala Gln Tyr Arg Asn Asn Ala Ala His 
        835                 840                 845             


Leu Asn Ala Ile Arg Asn Ala His Leu Tyr Ile Arg Glu Met Lys Ser 
    850                 855                 860                 


Val Arg Ser Tyr Phe Glu Leu Tyr His Tyr Leu Thr Gln Arg Ala Leu 
865                 870                 875                 880 


Leu Asp Lys Tyr Glu Asn Val Pro Tyr His Pro Gln Val Asn Glu Lys 
                885                 890                 895     


Thr Leu Lys Tyr Phe Glu Leu Leu Lys Glu Asn Gly Trp Tyr Cys Lys 
            900                 905                 910         


Asp Phe Val Lys Ala Leu Asn Val Pro Phe Gly Tyr Asn Leu Pro Arg 
        915                 920                 925             


Tyr Lys Asn Leu Ser Ile Asp Ala Leu Phe Asp Lys Asp Arg Pro Gln 
    930                 935                 940                 


Glu Glu Asp Glu Asn His Leu Tyr Thr Cys Gln Asn Ile Lys Lys Ser 
945                 950                 955                 960 


<210>  2902
<211>  933
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2902

Met Glu Arg Gln Lys Arg Lys Met Lys Ser Lys Ser Lys Met Ala Gly 
1               5                   10                  15      


Val Lys Ser Val Phe Val Ile Gly Asp Glu Leu Leu Met Thr Ser Phe 
            20                  25                  30          


Gly Asp Gly Asp Asp Ala Val Leu Glu Lys Asp Ile Asp Glu Asn Gly 
        35                  40                  45              


Val Val Asn Asp Cys Arg Asn Pro Ala Ala Tyr Asp Ala Val Tyr Gly 
    50                  55                  60                  


Thr Asp Ser Ile Arg Val Lys Lys Thr Asn Asn Asn Ile Arg Ala Lys 
65                  70                  75                  80  


Val Asn Asn Pro Leu Ala Lys Ser Asn Ile Arg Ser Glu Glu Ser Ala 
                85                  90                  95      


Leu Phe Arg Thr Arg Val Asn Glu Tyr Lys Arg Glu Gln Lys Asp Lys 
            100                 105                 110         


Tyr Glu Thr Leu Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile 
        115                 120                 125             


Gln Leu Ile Ser Lys Ile Leu Asp Ile Glu Lys Thr Phe Ser Val Val 
    130                 135                 140                 


Ile Gly Asn Ile Val Tyr Ala Ile Asn Asn Leu Ser Leu Glu Gln Ser 
145                 150                 155                 160 


Ile Asp Arg Pro Ile Asp Ile Phe Gly Asp Lys Asn Thr Gln Gly Ile 
                165                 170                 175     


Ser Leu Arg Glu Asp Asn Asp Tyr Leu Lys Thr Met Leu Pro Arg Cys 
            180                 185                 190         


Glu Tyr Leu Phe His Asn Ile Leu Asn Ser Asp Ser Asn Asn Asn Ser 
        195                 200                 205             


Lys Met Asn Tyr Asn Lys Val Asn Lys Gly Lys Glu Glu Lys Asp Asn 
    210                 215                 220                 


Arg Asn Asn Glu Asn Ile Glu Lys Leu Lys Lys Ala Leu Glu Val Ile 
225                 230                 235                 240 


Lys Ile Ile Arg Val Asp Ser Phe His Gly Val Asp Gly Ile Lys Gly 
                245                 250                 255     


Asp Gln Lys Phe Pro Arg Ser Lys Tyr Asn Leu Ala Val Asn Tyr Asn 
            260                 265                 270         


Glu Glu Ile Gln Lys Thr Ile Ser Glu Pro Phe Asn Arg Lys Val Glu 
        275                 280                 285             


Glu Val Gln Gln Asp Phe Tyr Arg Asn Ser Cys Val Asn Ile Asp Phe 
    290                 295                 300                 


Leu Lys Glu Ile Met Tyr Gly Ser Asn Tyr Thr Asp Arg Gly Ser Asp 
305                 310                 315                 320 


Ser Leu Glu Cys Ser Tyr Phe Asn Phe Ala Ile Leu Lys Gln Asn Lys 
                325                 330                 335     


Asn Met Gly Phe Ser Ile Thr Ser Ile Arg Glu Cys Leu Leu Asp Leu 
            340                 345                 350         


Tyr Glu Leu Asn Phe Glu Ser Met Gln Asn Leu Arg Pro Arg Ala Asn 
        355                 360                 365             


Ser Phe Cys Asp Phe Leu Ile Tyr Asp Tyr Tyr Cys Lys Asn Glu Ser 
    370                 375                 380                 


Glu Arg Ala Asn Leu Val Asp Cys Leu Arg Ser Ala Ala Ser Glu Glu 
385                 390                 395                 400 


Glu Lys Lys Asn Ile Tyr Phe Gln Thr Ala Glu Arg Val Lys Glu Lys 
                405                 410                 415     


Phe Arg Asn Ala Phe Asn Arg Ile Ser Arg Phe Asp Ala Ser Tyr Ile 
            420                 425                 430         


Lys Asn Ser Arg Glu Lys Asn Leu Ser Gly Gly Ser Ser Leu Pro Lys 
        435                 440                 445             


Tyr Ser Phe Ile Glu Gly Phe Thr Lys Arg Ser Lys Lys Ile Asn Asp 
    450                 455                 460                 


Asn Asp Glu Lys Asn Ala Asp Leu Phe Cys Asn Met Leu Tyr Tyr Leu 
465                 470                 475                 480 


Ala Gln Phe Leu Asp Gly Lys Glu Ile Asn Ile Phe Leu Thr Ser Ile 
                485                 490                 495     


His Asn Ile Phe Gln Asn Ile Asp Ser Phe Leu Lys Val Met Lys Glu 
            500                 505                 510         


Lys Gly Met Glu Cys Lys Phe Gln Lys Asp Phe Lys Met Phe Ser His 
        515                 520                 525             


Ala Gly His Val Ala Lys Lys Ile Glu Ile Val Ile Ser Leu Ala Lys 
    530                 535                 540                 


Met Lys Lys Thr Leu Asp Phe Tyr Asn Thr Gln Ala Leu Lys Asp Ala 
545                 550                 555                 560 


Val Thr Ile Leu Gly Val Ser Lys Lys His Gln Tyr Leu Asp Met Asn 
                565                 570                 575     


Ser Tyr Leu Asp Phe Tyr Met Phe Asp Asn Arg Ser Gly Ala Thr Gly 
            580                 585                 590         


Lys Asn Ala Gly Lys Asp His Asn Leu Arg Asn Phe Leu Val Ser Asn 
        595                 600                 605             


Val Ile Arg Ser Arg Lys Phe Asn Tyr Leu Ser Arg Tyr Ser Asn Leu 
    610                 615                 620                 


Ala Glu Val Lys Lys Leu Ala Gln Asn Pro Ser Leu Val Gln Phe Val 
625                 630                 635                 640 


Leu Ser Arg Ile Glu Pro Ser Leu Ile Cys Arg Tyr Tyr Glu Ser Ser 
                645                 650                 655     


Gln Gly Ile Ser Ser Glu Gly Ile Thr Ile Asp Glu Gln Ile Lys Lys 
            660                 665                 670         


Leu Thr Gly Ile Ile Val Asp Met Asn Ile Asp Ser Phe Glu Asn Ile 
        675                 680                 685             


Asn Asn Gly Glu Ile Gly Met Arg Tyr Ser Lys Ala Thr Pro Gln Ser 
    690                 695                 700                 


Ile Glu Arg Arg Asn Gln Met Arg Val Cys Val Gly Leu Tyr Leu Asn 
705                 710                 715                 720 


Val Leu Tyr Gln Ile Glu Lys Asn Leu Met Asn Val Asn Ala Arg Tyr 
                725                 730                 735     


Val Leu Ala Phe Ala Phe Ala Glu Arg Asp Ala Leu Met Leu Asn Phe 
            740                 745                 750         


Thr Leu Glu Glu Cys Lys Lys Asn Lys Lys Arg Ser Ser Gly Gly Phe 
        755                 760                 765             


Ser Phe Ile Glu Met Thr Gln Phe Phe Ile Asp Lys Lys Leu Phe Lys 
    770                 775                 780                 


Val Ala Thr Glu Ala Ile Lys Lys Asn Val Leu Lys Tyr Asn Gly Asn 
785                 790                 795                 800 


Pro Glu Ser Leu Asn His Ile Pro Gly Glu Tyr Ile Cys Lys Asn Met 
                805                 810                 815     


Glu Gly Tyr His Glu Asn Thr Val Arg Asn Phe Arg Asn Met Val Ala 
            820                 825                 830         


His Leu Thr Ala Val Ala Arg Val Pro Leu Tyr Ile Ser Glu Val Thr 
        835                 840                 845             


Gln Ile Asp Ser Tyr Tyr Ala Leu Tyr His Tyr Cys Met Gln Met Asn 
    850                 855                 860                 


Ile Leu Gln Gly Ile Glu Gln Ser Gly Lys Ile Leu Asp Asn Ile Lys 
865                 870                 875                 880 


Leu Lys Asn Ala Leu Glu Asn Ala Arg Val His Arg Thr Tyr Ser Lys 
                885                 890                 895     


Asp Ala Val Lys Tyr Leu Cys Leu Pro Phe Ala Tyr Asn Ile Ser Arg 
            900                 905                 910         


Tyr Lys Ala Leu Thr Ile Lys Asp Leu Phe Asp Trp Thr Glu Tyr Ser 
        915                 920                 925             


Cys Lys Lys Asp Glu 
    930             


<210>  2903
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2903

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Lys Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asn Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Ile Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Asn Arg Val Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Glu Asp 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Asp Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Val Ser Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Asn Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Ile Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Asn Lys Tyr Ile Asn Asp Ile Tyr Val Val Asn Ser Tyr 
        835                 840                 845             


Phe Ser Ile Cys His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Lys Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2904
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2904

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asp Asn Asp Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asn 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Ser Val Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Gln Asn Thr Tyr Tyr Ile 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val 
            260                 265                 270         


Ser Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu 
    290                 295                 300                 


Tyr Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Val Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Ile Ala Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Leu Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2905
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2905

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Gly Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asp Tyr Asn 
                85                  90                  95      


Gln Thr Gln Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu Cys Gly 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Lys Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Ala Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe 
                325                 330                 335     


Ile Glu Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Phe Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Glu Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Cys Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Asp Arg Asp Lys Ser Ser Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asp Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asn Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  2906
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2906

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Gln Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ser Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ser Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Lys Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Arg Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2907
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2907

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Asp Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Lys 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Leu Glu Asn Glu Ser Asn Asn Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe Thr Asp Pro 
    210                 215                 220                 


Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn Ile Lys Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu Tyr Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Ile Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Asp Asp Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Ile Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Arg Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2908
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2908

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Gln Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Gly Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ser 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr 
    850                 855                 860                 


Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  2909
<211>  954
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2909

Met Gly Lys Lys Ile His Ala Arg Asp Leu Arg Glu Arg Arg Lys Thr 
1               5                   10                  15      


Asp Arg Thr Glu Lys Phe Ala Asp Gln Asn Lys Lys Arg Glu Ala Glu 
            20                  25                  30          


Arg Ala Val Gln Lys Lys Asp Ala Ala Val Ser Val Lys Ser Val Ser 
        35                  40                  45              


Ser Val Ser Ser Lys Lys Asp Asn Val Thr Lys Ser Met Ala Lys Ala 
    50                  55                  60                  


Ala Gly Val Lys Ser Val Phe Ala Val Gly Asn Thr Val Tyr Met Thr 
65                  70                  75                  80  


Ser Phe Gly Arg Gly Asn Asp Ala Val Leu Glu Gln Lys Ile Val Asp 
                85                  90                  95      


Thr Ser His Glu Pro Leu Asn Ile Asp Asp Pro Ala Tyr Gln Leu Asn 
            100                 105                 110         


Val Val Thr Met Asn Gly Tyr Ser Val Thr Gly His Arg Gly Glu Thr 
        115                 120                 125             


Val Ser Ala Val Thr Asp Asn Pro Leu Arg Arg Phe Asn Gly Gly Lys 
    130                 135                 140                 


Lys Asp Glu Pro Glu Gln Ser Val Pro Thr Asp Met Leu Cys Leu Lys 
145                 150                 155                 160 


Pro Thr Leu Glu Lys Lys Phe Phe Gly Lys Glu Phe Asp Asp Asn Ile 
                165                 170                 175     


His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala 
            180                 185                 190         


Val Tyr Ser Thr Asn Ala Ile Tyr Ala Leu Asn Asn Met Ser Ala Asp 
        195                 200                 205             


Glu Asn Ile Glu Ser Ser Asp Phe Phe Met Lys Arg Thr Thr Asp Glu 
    210                 215                 220                 


Thr Phe Asp Asp Phe Glu Lys Lys Lys Glu Ser Thr Asn Ser Arg Glu 
225                 230                 235                 240 


Lys Ala Asp Phe Asp Ala Phe Glu Lys Phe Ile Gly Asn Tyr Arg Leu 
                245                 250                 255     


Ala Tyr Phe Ala Asp Ala Phe Tyr Val Asn Lys Lys Asn Pro Lys Gly 
            260                 265                 270         


Lys Ala Arg Asn Val Leu Arg Glu Asp Lys Glu Leu Tyr Ser Val Leu 
        275                 280                 285             


Thr Leu Ile Gly Lys Leu Arg His Trp Cys Val His Ser Glu Glu Gly 
    290                 295                 300                 


Arg Ala Glu Phe Trp Leu Tyr Lys Leu Asp Glu Leu Lys Asp Asp Phe 
305                 310                 315                 320 


Lys Asn Val Leu Asp Val Val Tyr Asn Arg Pro Val Glu Glu Ile Asn 
                325                 330                 335     


Asn Arg Phe Ile Glu Asn Asn Lys Val Asn Ile Gln Ile Leu Gly Ser 
            340                 345                 350         


Val Tyr Lys Asn Thr Asp Ile Ala Glu Leu Val Arg Ser Tyr Tyr Glu 
        355                 360                 365             


Phe Leu Ile Thr Lys Lys Tyr Lys Asn Met Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Ser Met Leu Glu Gly Lys Gly Tyr Ala Asp Lys Glu Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Asn Lys Leu Tyr Gln Met Thr Asp Phe Ile Leu Tyr 
                405                 410                 415     


Thr Gly Tyr Ile Asn Glu Asp Ser Asp Arg Ala Asp Asp Leu Val Asn 
            420                 425                 430         


Thr Leu Arg Ser Ser Leu Lys Glu Asp Asp Lys Thr Thr Val Tyr Cys 
        435                 440                 445             


Lys Glu Ala Asp Tyr Leu Trp Lys Lys Tyr Arg Glu Ser Ile Arg Glu 
    450                 455                 460                 


Val Ala Asp Ala Leu Asp Gly Asp Asn Ile Lys Arg Leu Ser Lys Ser 
465                 470                 475                 480 


Asn Ile Glu Ile Gln Glu Asp Lys Leu Arg Lys Cys Phe Ile Ser Tyr 
                485                 490                 495     


Ala Asp Ser Val Ser Glu Phe Thr Lys Leu Ile Tyr Leu Leu Thr Arg 
            500                 505                 510         


Phe Leu Ser Gly Lys Glu Ile Asn Asp Leu Val Thr Thr Leu Ile Asn 
        515                 520                 525             


Lys Phe Asp Asn Ile Arg Ser Phe Leu Glu Ile Met Asp Glu Leu Gly 
    530                 535                 540                 


Leu Asp Arg Thr Phe Thr Ala Glu Tyr Ser Phe Phe Glu Gly Ser Thr 
545                 550                 555                 560 


Lys Tyr Leu Ala Glu Leu Val Glu Leu Asn Ser Phe Val Lys Ser Cys 
                565                 570                 575     


Ser Phe Asp Ile Asn Ala Lys Arg Thr Met Tyr Arg Asp Ala Leu Asp 
            580                 585                 590         


Ile Leu Gly Ile Lys Ser Gly Lys Thr Glu Glu Asp Ile Glu Lys Met 
        595                 600                 605             


Ile Asp Asn Ile Leu Gln Ile Asp Ala Asn Gly Asp Lys Lys Leu Lys 
    610                 615                 620                 


Lys Asn Asn Gly Leu Arg Asn Phe Ile Ala Ser Asn Val Ile Asp Ser 
625                 630                 635                 640 


Asn Arg Phe Lys Tyr Leu Val Arg Tyr Gly Asn Pro Lys Lys Ile Arg 
                645                 650                 655     


Glu Thr Ala Lys Cys Lys Pro Ala Val Arg Phe Val Leu Asn Glu Ile 
            660                 665                 670         


Pro Asp Ala Gln Ile Glu Arg Tyr Tyr Glu Ala Cys Cys Pro Lys Asn 
        675                 680                 685             


Thr Ala Leu Cys Ser Ala Asn Lys Arg Arg Glu Lys Leu Ala Asp Met 
    690                 695                 700                 


Ile Ala Glu Ile Glu Phe Glu Asn Phe Ser Asp Ala Gly Asn Tyr Gln 
705                 710                 715                 720 


Lys Ala Asn Val Thr Ser Arg Thr Ser Glu Ala Glu Ile Lys Arg Lys 
                725                 730                 735     


Asn Gln Ala Ile Ile Arg Leu Tyr Leu Thr Val Met Tyr Ile Met Leu 
            740                 745                 750         


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Phe His Cys 
        755                 760                 765             


Val Glu Arg Asp Thr Lys Leu Tyr Ala Glu Ser Gly Leu Glu Val Gly 
    770                 775                 780                 


Asn Ile Glu Lys Asn Lys Thr Asn Leu Thr Met Ala Val Met Gly Val 
785                 790                 795                 800 


Lys Ile Glu Asn Gly Ile Ile Lys Thr Glu Phe Asp Lys Ser Leu Ala 
                805                 810                 815     


Glu Asn Ala Ala Asn Arg Tyr Leu Arg Asn Ala Arg Trp Tyr Lys Leu 
            820                 825                 830         


Ile Leu Asp Asn Leu Lys Lys Ser Glu Arg Ala Val Val Asn Glu Phe 
        835                 840                 845             


Arg Asn Thr Val Cys His Leu Asn Ala Ile Arg Asn Ile Asn Ile Asn 
    850                 855                 860                 


Ile Asp Gly Ile Lys Glu Val Glu Asn Tyr Phe Ala Leu Tyr His Tyr 
865                 870                 875                 880 


Leu Ile Gln Lys His Leu Glu Asn Arg Phe Ala Asp Lys Lys Val Glu 
                885                 890                 895     


Arg Asp Thr Gly Asp Phe Ile Ser Lys Leu Glu Glu His Lys Thr Tyr 
            900                 905                 910         


Cys Lys Asp Phe Val Lys Ala Tyr Cys Thr Pro Phe Gly Tyr Asn Leu 
        915                 920                 925             


Val Arg Tyr Lys Asn Leu Thr Ile Asp Gly Leu Phe Asp Lys Asn Tyr 
    930                 935                 940                 


Pro Gly Lys Asp Asp Ser Asp Lys Gln Lys 
945                 950                 


<210>  2910
<211>  924
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2910

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Phe Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Leu Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Leu Ser Glu His Ser Glu Tyr Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asp Asn Ser Lys Lys Val Tyr Arg Glu Cys Arg Glu Thr Leu 
305                 310                 315                 320 


Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile 
                325                 330                 335     


Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly 
            340                 345                 350         


Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu 
        355                 360                 365             


Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys 
    370                 375                 380                 


Ile Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser 
385                 390                 395                 400 


Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn 
                405                 410                 415     


Tyr Tyr Arg Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu 
            420                 425                 430         


Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu 
        435                 440                 445             


Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala 
    450                 455                 460                 


Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met 
465                 470                 475                 480 


Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp 
                485                 490                 495     


Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp 
            500                 505                 510         


Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp 
        515                 520                 525             


Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Ile Asp Val 
    530                 535                 540                 


Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg 
545                 550                 555                 560 


Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys 
                565                 570                 575     


Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile 
            580                 585                 590         


Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu 
        595                 600                 605             


Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile 
    610                 615                 620                 


Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr 
625                 630                 635                 640 


Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val 
                645                 650                 655     


Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr 
            660                 665                 670         


Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys 
        675                 680                 685             


Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe 
    690                 695                 700                 


Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu 
705                 710                 715                 720 


Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu 
                725                 730                 735     


Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His 
            740                 745                 750         


Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu 
        755                 760                 765             


Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu 
    770                 775                 780                 


Cys Glu Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys 
785                 790                 795                 800 


Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala 
                805                 810                 815     


Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr 
            820                 825                 830         


Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp 
        835                 840                 845             


Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys 
    850                 855                 860                 


Arg Glu Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp 
865                 870                 875                 880 


Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn 
                885                 890                 895     


Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu 
            900                 905                 910         


Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 


<210>  2911
<211>  918
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2911

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Gly Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Asn Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp 
    370                 375                 380                 


Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Gly Val Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ser Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu Arg 
785                 790                 795                 800 


Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr Arg 
                805                 810                 815     


Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu Lys 
            820                 825                 830         


Glu Tyr Ile Gly Asp Ile Cys Thr Val Asp Ser Tyr Phe Ser Ile Tyr 
        835                 840                 845             


His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr Lys 
    850                 855                 860                 


Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His Gly 
865                 870                 875                 880 


Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr Asn 
                885                 890                 895     


Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg Asn 
            900                 905                 910         


Glu Tyr Leu Thr Glu Lys 
        915             


<210>  2912
<211>  975
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2912

Met Met Gly Lys His Leu Asn Ala Lys Gln Arg Glu Leu Glu Lys Lys 
1               5                   10                  15      


Leu Lys Asn Gln Gln Lys Gly Met Met Tyr Asn Lys Ser Thr Asp Ala 
            20                  25                  30          


Val Ser Val Pro Thr Leu Gln Ala Ala Pro Lys Lys Ala Ala Glu Ala 
        35                  40                  45              


Ser Thr Leu Ile Thr Pro Gly Thr Leu Lys Thr Lys Ala Lys Ala Met 
    50                  55                  60                  


Gly Leu Lys Ser Thr Leu Val Phe Asp Asp Lys Ile Val Val Thr Ser 
65                  70                  75                  80  


Phe Leu Asn Ser Lys Thr Glu Glu Asn Glu Lys Cys Ala His Ile Glu 
                85                  90                  95      


Lys Ile Thr Asp Cys Asn Gly Gln Thr Ile Val Glu Arg Pro Arg Met 
            100                 105                 110         


Phe Asn Thr Ser Ile Asn Ala Gln Gln Val Asp Leu Ser Lys Asp Asn 
        115                 120                 125             


Asp Glu Thr Asn Tyr Pro Asn Pro Ala Phe Glu Asp Cys Gly Arg Asp 
    130                 135                 140                 


Tyr Ile Asn Ile Lys Ser Ala Leu Glu Lys Arg Val Phe Gly Lys Thr 
145                 150                 155                 160 


Tyr Asn Lys Asp Asn Leu His Val Gln Ile Ala Tyr Asn Ile Phe Asp 
                165                 170                 175     


Ile Lys Lys Ile Ile Gly Thr Tyr Ile Asn Asn Ile Thr Tyr Ile Phe 
            180                 185                 190         


Tyr Asn Leu Gly Arg Glu Glu Tyr Asn Ala Lys Lys Asp Ile Ile Gly 
        195                 200                 205             


Asn Gln Asp Ser Asp Tyr Ile Asn Lys Leu Leu Asn Asn Thr Ser Ala 
    210                 215                 220                 


Tyr Phe Thr Tyr Phe Asp Gly Val Phe Lys Gln Ile Thr Asp Arg Asp 
225                 230                 235                 240 


Ser Asn Lys Asp Arg Glu Val Lys Asn Ser Tyr Asn Ala Leu Val Leu 
                245                 250                 255     


Lys Val Leu Tyr Tyr Leu Arg Gln Phe Cys Met His Gly Asn Thr Tyr 
            260                 265                 270         


Thr Lys Arg Asn Glu Glu Ser Phe Leu Ser Asp Thr Ala Leu Tyr Asn 
        275                 280                 285             


Val Lys Asp Phe Phe Ala Lys Ala Asp Pro Gln Ile Asn Glu Leu Ile 
    290                 295                 300                 


Asp Ala Val Tyr Ala Asp Gly Ile Lys Thr Ile Asn Asn Asp Phe Met 
305                 310                 315                 320 


Ala His Ala Lys Asn Asn Met Tyr Ile Ile Cys Glu Val Tyr Lys Asn 
                325                 330                 335     


Glu Val Glu Asp Ser Leu Met Lys Glu Tyr Tyr Asp Phe Val Val Arg 
            340                 345                 350         


Lys Glu Gly Asn Asn Leu Gly Phe Asn Thr Arg Gln Leu Arg Glu Ile 
        355                 360                 365             


Leu Ile Asp Lys Tyr Val Gly Asn Leu Arg Asp Lys Lys Tyr Asp Thr 
    370                 375                 380                 


Phe Arg Asn Lys Leu Tyr Thr Val Leu Gly Phe Ile Leu Val Lys Glu 
385                 390                 395                 400 


Ile Lys Arg Asn Pro Lys Ile Gln Asp Ser Phe Ile Ala Lys Leu Arg 
                405                 410                 415     


Ala Asn Gln Ser Gly Asp Glu Gly Lys Leu Asn Ile Tyr Asn Glu Phe 
            420                 425                 430         


Ala Pro Lys Ile Trp Ser Val Val Ser Ser Lys Phe Asn Ser Ala Ile 
        435                 440                 445             


Thr Cys Phe Asp Glu Glu Ser Leu Ser Lys Phe Lys Gly Tyr Lys Asp 
    450                 455                 460                 


Ile Asp Glu Ser Leu Ile Ser Lys Tyr Gly Ile Thr Val Ser Asn Thr 
465                 470                 475                 480 


Asp Thr Leu Val Lys Ile Leu Tyr Phe Leu Cys Lys Phe Leu Asp Gly 
                485                 490                 495     


Lys Glu Ile Asn Glu Leu Cys Cys Ala Met Ile Asn Lys Phe Asp Asn 
            500                 505                 510         


Ile Asn Asp Leu Ile Lys Thr Ala Ala Gln Cys Gly Glu Asp Ile Glu 
        515                 520                 525             


Phe Val Lys Glu Tyr Lys Leu Phe Ile Asn Ser Lys Asp Ile Ser Asp 
    530                 535                 540                 


Gln Ile Arg Val Val Lys Ser Ile Ser Lys Met Lys Pro Glu Leu Ser 
545                 550                 555                 560 


Asn Ile Gly Glu Val Leu Leu Leu Asp Ala Ile Asp Ile Leu Gly Tyr 
                565                 570                 575     


Lys Ile Asn Lys Tyr Lys Cys Asp Ala Asp Gly Asn Arg Leu Val Asp 
            580                 585                 590         


Ser Asn Asn Lys Pro Val Tyr Ser Glu Glu Tyr Cys Thr Phe Lys Lys 
        595                 600                 605             


Asp Phe Phe Glu Thr Cys Glu Leu Asp Glu Phe Gly Arg Val Lys Tyr 
    610                 615                 620                 


Asp Lys Lys Gly Lys Pro Val Ile Asn His Arg Arg Arg Asn Phe Ile 
625                 630                 635                 640 


Ile Asn Asn Val Leu Ser Ser Lys Trp Phe Phe Tyr Val Ala Lys Tyr 
                645                 650                 655     


Asn Arg Pro Ser Glu Cys Gln Lys Phe Met Lys Ser Lys Lys Leu Ile 
            660                 665                 670         


Ala Leu Ala Leu Lys Asp Val Pro Glu Thr Gln Ile Ala Arg Tyr Tyr 
        675                 680                 685             


His Ser Val Thr Gly Gly Arg Glu Gln Thr Asp Ser Glu Ala Met Arg 
    690                 695                 700                 


Thr Thr Leu Ile Ser Arg Leu His Glu Phe Ser Ile Lys Asp Val Leu 
705                 710                 715                 720 


Ser Ser Val Gly Ser Met Thr Ala Ser Glu Asn Lys Arg Gln Ile Glu 
                725                 730                 735     


Asn Ser Arg Lys Glu Gln Met Lys Ala Ile Val Lys Leu Tyr Leu Thr 
            740                 745                 750         


Val Val Tyr Leu Ile Ala Lys Ser Leu Val Lys Val Asn Thr Arg Phe 
        755                 760                 765             


Ser Ile Ala Phe Ser Ala Tyr Glu Arg Asp Val Ser Leu Leu Ala Asp 
    770                 775                 780                 


Glu Asn Glu Ser Ile Ala Leu Ala Asp Asn Asp Asp Asp Lys Trp Lys 
785                 790                 795                 800 


Thr Gly Asn Tyr Ile Phe Ala Leu Thr Lys His Phe Leu Asp Asn Asp 
                805                 810                 815     


Glu Pro Tyr Phe Asp Lys Tyr Asn Asn Ala Leu Gln Gln Ile Lys Gly 
            820                 825                 830         


Ile Thr Asp Pro Asn Glu Arg Arg Leu Ala Tyr Arg Ala Asn Asp Lys 
        835                 840                 845             


Val Ile Lys His Thr His Phe Asn Leu His Thr Asn Lys Tyr Val Lys 
    850                 855                 860                 


Asp Asn Tyr Glu Lys Ile Ser Lys Met Asn Lys Ile Val Thr Glu Tyr 
865                 870                 875                 880 


Arg Asn Asn Val Gln His Leu Ala Val Val Asn Asn Ile Thr Lys Tyr 
                885                 890                 895     


Leu Gly Asp Ile Ser Glu Val Thr Ser Tyr Tyr Ser Leu Tyr Cys Tyr 
            900                 905                 910         


Ile Leu Gln Arg Leu Leu Leu Asp Asn Asn Asn Asn Asp Lys Phe Ala 
        915                 920                 925             


Ala Ile Lys Glu Lys Leu Ile Lys Phe Gly Thr Tyr Asn Lys Asp Phe 
    930                 935                 940                 


Met Trp Leu Ile Asn Val Pro Phe Ala Tyr Asn Leu Pro Arg Tyr Lys 
945                 950                 955                 960 


Asn Leu Ser Asn Glu Glu Ile Phe Tyr Asp Val Ile Gln Asn Lys 
                965                 970                 975 


<210>  2913
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2913

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Met Lys 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Ile Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Asn Arg Val Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2914
<211>  918
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2914

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asn Asn Ile Tyr Pro Glu Tyr Arg Asp Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp 
    370                 375                 380                 


Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Val Val Ala Gly Glu Ser Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Gly Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ser 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Lys Val Ala Lys Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu Arg 
785                 790                 795                 800 


Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr Arg 
                805                 810                 815     


Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu Lys 
            820                 825                 830         


Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile Tyr 
        835                 840                 845             


His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp Asp Thr Lys 
    850                 855                 860                 


Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His Gly 
865                 870                 875                 880 


Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr Asn 
                885                 890                 895     


Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg Asn 
            900                 905                 910         


Glu Tyr Leu Thr Glu Lys 
        915             


<210>  2915
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2915

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Phe Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Glu Asp Ser Ser Asn Ile Glu Leu Cys Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Ile Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu Tyr Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Val Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Ile Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Leu Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Lys Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Gln 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp Asp Thr 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  2916
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2916

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Ile Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Pro Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn His Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2917
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2917

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Tyr Asn Ser Asn Ile Glu Leu Gly Asp Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Met Lys 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Ile Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Asn Arg Val Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2918
<211>  975
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2918

Met Met Gly Lys His Leu Asn Ala Lys Gln Arg Glu Leu Glu Lys Lys 
1               5                   10                  15      


Leu Lys Asn Gln Gln Lys Gly Met Met Tyr Asn Lys Ser Thr Asp Ala 
            20                  25                  30          


Val Ser Val Pro Thr Leu Gln Ala Ala Pro Lys Lys Ala Ala Glu Ala 
        35                  40                  45              


Ser Thr Leu Ile Thr Pro Gly Thr Leu Lys Thr Lys Ala Lys Ala Met 
    50                  55                  60                  


Gly Leu Lys Ser Thr Leu Val Phe Asp Asp Lys Ile Val Val Thr Ser 
65                  70                  75                  80  


Phe Leu Asn Ser Lys Thr Glu Glu Asn Glu Lys Cys Ala His Ile Glu 
                85                  90                  95      


Lys Ile Thr Asp Cys Asn Gly Gln Thr Ile Val Glu Arg Pro Arg Met 
            100                 105                 110         


Phe Asn Thr Ser Ile Asn Ala Gln Gln Val Asp Leu Ser Lys Asp Asn 
        115                 120                 125             


Asp Glu Thr Asn Tyr Pro Asn Pro Ala Phe Glu Asp Cys Gly Arg Asp 
    130                 135                 140                 


Tyr Ile Asn Ile Lys Ser Ala Leu Glu Lys Arg Val Phe Gly Lys Thr 
145                 150                 155                 160 


Tyr Asn Lys Asp Asn Leu His Val Gln Ile Ala Tyr Asn Ile Phe Asp 
                165                 170                 175     


Ile Lys Lys Ile Ile Gly Thr Tyr Ile Asn Asn Ile Thr Tyr Ile Phe 
            180                 185                 190         


Tyr Asn Leu Gly Arg Glu Glu Tyr Asn Ala Lys Lys Asp Ile Ile Gly 
        195                 200                 205             


Asn Gln Asp Ser Asp Tyr Ile Asn Lys Leu Leu Asn Asn Thr Ser Ala 
    210                 215                 220                 


Tyr Phe Thr Tyr Phe Asp Gly Val Phe Lys Gln Ile Thr Asp Arg Asp 
225                 230                 235                 240 


Ser Asn Lys Asp Arg Glu Val Lys Asn Ser Tyr Asn Ala Leu Val Leu 
                245                 250                 255     


Lys Val Leu Tyr Tyr Leu Arg Gln Phe Cys Met His Gly Asn Thr Tyr 
            260                 265                 270         


Thr Lys Arg Asn Glu Glu Ser Phe Leu Ser Asp Thr Ala Leu Tyr Asn 
        275                 280                 285             


Val Lys Asp Phe Phe Ala Lys Ala Asp Pro Gln Ile Asn Glu Leu Ile 
    290                 295                 300                 


Asp Ala Val Tyr Ala Asp Gly Ile Lys Thr Ile Asn Asn Asp Phe Met 
305                 310                 315                 320 


Ala His Ala Lys Asn Asn Met Tyr Ile Ile Cys Glu Val Tyr Lys Asn 
                325                 330                 335     


Glu Val Glu Asp Ser Leu Met Lys Glu Tyr Tyr Asp Phe Val Val Arg 
            340                 345                 350         


Lys Glu Gly Asn Asn Leu Gly Phe Asn Thr Arg Gln Leu Arg Glu Ile 
        355                 360                 365             


Leu Ile Asp Lys Tyr Val Gly Asn Leu Arg Asp Lys Lys Tyr Asp Thr 
    370                 375                 380                 


Phe Arg Asn Lys Leu Tyr Thr Val Leu Gly Phe Ile Leu Val Lys Glu 
385                 390                 395                 400 


Ile Lys Arg Asn Pro Lys Ile Gln Asp Ser Phe Ile Ala Lys Leu Arg 
                405                 410                 415     


Ala Asn Gln Ser Gly Asp Glu Gly Lys Leu Asn Ile Tyr Asn Glu Phe 
            420                 425                 430         


Ala Pro Lys Ile Trp Ser Val Val Ser Ser Lys Phe Asn Ser Ala Ile 
        435                 440                 445             


Lys Cys Phe Asp Glu Glu Ser Leu Ser Lys Phe Lys Gly Tyr Lys Asp 
    450                 455                 460                 


Ile Asp Glu Ser Leu Ile Ser Lys Tyr Gly Ile Thr Val Ser Asn Thr 
465                 470                 475                 480 


Asp Thr Leu Val Lys Ile Leu Tyr Phe Leu Cys Lys Phe Leu Asp Gly 
                485                 490                 495     


Lys Glu Ile Asn Glu Leu Cys Cys Ala Met Ile Asn Lys Phe Asp Asn 
            500                 505                 510         


Ile Asn Asp Leu Ile Lys Thr Ala Ala Gln Cys Gly Glu Asp Ile Glu 
        515                 520                 525             


Phe Val Lys Glu Tyr Lys Leu Phe Ile Asn Ser Lys Asp Leu Ser Asp 
    530                 535                 540                 


Gln Ile Arg Val Val Lys Ser Ile Ser Lys Met Lys Pro Glu Leu Ser 
545                 550                 555                 560 


Asn Ile Gly Glu Val Leu Leu Leu Asp Ala Ile Asp Ile Leu Gly Tyr 
                565                 570                 575     


Lys Ile Asn Lys Tyr Lys Cys Asp Ala Asp Gly Asn Arg Leu Val Asp 
            580                 585                 590         


Ser Asn Asn Lys Pro Val Tyr Ser Glu Glu Tyr Cys Thr Phe Lys Lys 
        595                 600                 605             


Asp Phe Phe Glu Thr Cys Glu Leu Asp Glu Phe Gly Arg Val Lys Tyr 
    610                 615                 620                 


Asp Lys Lys Gly Lys Pro Val Ile Asn His Arg Arg Arg Asn Phe Ile 
625                 630                 635                 640 


Ile Asn Asn Val Leu Ser Ser Lys Trp Phe Phe Tyr Val Ala Lys Tyr 
                645                 650                 655     


Asn Arg Pro Ser Glu Cys Gln Lys Phe Met Lys Ser Lys Lys Leu Ile 
            660                 665                 670         


Ala Leu Ala Leu Lys Asp Val Pro Glu Thr Gln Ile Ala Arg Tyr Tyr 
        675                 680                 685             


His Ser Val Thr Gly Gly Arg Glu Gln Thr Asp Ser Glu Ala Met Arg 
    690                 695                 700                 


Thr Thr Leu Ile Ser Arg Leu His Glu Phe Ser Ile Lys Asp Val Leu 
705                 710                 715                 720 


Ser Ser Val Gly Ser Met Thr Ala Ser Glu Asn Lys Arg Gln Ile Glu 
                725                 730                 735     


Asn Ser Arg Lys Glu Gln Met Lys Ala Ile Val Lys Leu Tyr Leu Thr 
            740                 745                 750         


Val Val Tyr Leu Ile Ala Lys Ser Leu Val Lys Val Asn Thr Arg Phe 
        755                 760                 765             


Ser Ile Ala Phe Ser Ala Tyr Glu Arg Asp Val Ser Leu Leu Ala Asp 
    770                 775                 780                 


Glu Asn Glu Ser Ile Ala Met Ala Asp Asn Asp Asp Asp Lys Trp Lys 
785                 790                 795                 800 


Thr Gly Asn Tyr Ile Phe Ala Leu Thr Lys His Phe Leu Asp Asn Asp 
                805                 810                 815     


Glu Pro Tyr Phe Asp Lys Tyr Asn Asn Ala Leu Gln Gln Ile Lys Gly 
            820                 825                 830         


Ile Thr Asp Pro Asn Glu Arg Arg Leu Ala Tyr Arg Ala Asn Asp Lys 
        835                 840                 845             


Val Ile Lys His Thr His Phe Asn Leu His Thr Asn Lys Tyr Val Lys 
    850                 855                 860                 


Asp Asn Tyr Glu Lys Ile Ser Lys Met Asn Lys Ile Val Thr Glu Tyr 
865                 870                 875                 880 


Arg Asn Asn Val Gln His Leu Ala Val Val Asn Asn Ile Thr Lys Tyr 
                885                 890                 895     


Leu Gly Asp Ile Ser Glu Val Thr Ser Tyr Tyr Ser Leu Tyr Cys Tyr 
            900                 905                 910         


Ile Leu Gln Arg Leu Leu Leu Asp Asn Asn Asn Asn Asp Lys Phe Ala 
        915                 920                 925             


Glu Ile Lys Glu Lys Leu Ile Lys Phe Gly Thr Tyr Asn Lys Asp Phe 
    930                 935                 940                 


Met Trp Leu Ile Asn Val Pro Phe Ala Tyr Asn Leu Pro Arg Tyr Lys 
945                 950                 955                 960 


Asn Leu Ser Asn Glu Glu Ile Phe Tyr Asp Val Ile Gln Asn Lys 
                965                 970                 975 


<210>  2919
<211>  984
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2919

Met Lys Lys Lys Asn Ile Arg Ala Thr Arg Glu Ala Leu Lys Ala Gln 
1               5                   10                  15      


Lys Ile Lys Lys Ser Gln Glu Asn Glu Ala Leu Lys Lys Gln Lys Leu 
            20                  25                  30          


Ala Glu Glu Ala Ala Gln Lys Arg Arg Glu Glu Leu Glu Lys Lys Asn 
        35                  40                  45              


Leu Ala Gln Trp Glu Glu Thr Ser Ala Glu Gly Arg Arg Ser Arg Val 
    50                  55                  60                  


Lys Ala Val Gly Val Lys Ser Val Phe Val Val Gly Asp Asp Leu Tyr 
65                  70                  75                  80  


Leu Ala Thr Phe Gly Asn Gly Asn Glu Thr Val Leu Glu Lys Lys Ile 
                85                  90                  95      


Ala Pro Asp Gly Lys Ile Thr Thr Phe Pro Glu Glu Glu Thr Phe Thr 
            100                 105                 110         


Ala Lys Leu Lys Phe Ala Gln Thr Glu Pro Thr Glu Ala Thr Ser Ile 
        115                 120                 125             


Gly Ile Ser Asn Gly Arg Ile Val Leu Pro Glu Ile Ser Val Asp Asn 
    130                 135                 140                 


Pro Leu His Thr Thr Met Gln Lys Asn Thr Ile Lys Arg Ser Ala Gly 
145                 150                 155                 160 


Glu Asp Met Leu Gln Leu Lys Asn Val Leu Glu Asn Arg Tyr Phe Asp 
                165                 170                 175     


Arg Ser Phe Asn Asp Asp Leu His Ile Arg Leu Ile Tyr Asn Ile Leu 
            180                 185                 190         


Asp Ile Glu Lys Ile Leu Ala Glu Tyr Thr Thr Asn Ala Val Phe Ala 
        195                 200                 205             


Ile Asp Asn Val Ser Gly Cys Ser Asp Asp Phe Leu Ser Asn Phe Ser 
    210                 215                 220                 


Thr Arg Asn Gln Trp Asp Glu Phe Gln Asn Pro Glu Gln His Arg Glu 
225                 230                 235                 240 


His Phe Gly Asn Lys Asp Asn Val Ile Cys Ser Val Lys Lys Gln Gln 
                245                 250                 255     


Asp Leu Phe Phe Asn Phe Phe Lys Asn Asn Arg Ile Gly Tyr Phe Gly 
            260                 265                 270         


Lys Ala Phe Phe His Ala Glu Ser Glu Arg Lys Ile Val Lys Lys Thr 
        275                 280                 285             


Ala Lys Glu Val Tyr His Ile Leu Thr Leu Ile Gly Ser Leu Arg Gln 
    290                 295                 300                 


Trp Ile Thr His Ser Thr Glu Gly Gly Ile Ser Arg Leu Trp Leu Tyr 
305                 310                 315                 320 


Gln Leu Glu Asp Ala Leu Ser Ser Glu Tyr Gln Glu Thr Met Asn Asn 
                325                 330                 335     


Cys Tyr Asn Ser Thr Ile Tyr Gly Leu Gln Lys Asp Phe Glu Lys Thr 
            340                 345                 350         


Asn Ala Pro Asn Leu Asn Phe Leu Ala Glu Ile Leu Gly Lys Asn Ala 
        355                 360                 365             


Ser Glu Leu Ala Glu Pro Tyr Phe Arg Phe Ile Ile Thr Lys Glu Tyr 
    370                 375                 380                 


Lys Asn Leu Gly Phe Ser Ile Lys Thr Leu Arg Glu Met Leu Leu Asp 
385                 390                 395                 400 


Gln Pro Asp Leu Gln Glu Ile Arg Glu Asn His Asn Val Tyr Asp Ser 
                405                 410                 415     


Ile Arg Ser Lys Leu Tyr Lys Met Met Asp Phe Val Leu Val Tyr Ala 
            420                 425                 430         


Tyr Ser Asn Glu Arg Lys Ser Lys Ala Asp Ala Leu Ala Ser Asn Leu 
        435                 440                 445             


Arg Ser Ala Ile Thr Glu Asp Ala Lys Lys Arg Ile Tyr Gln Asn Glu 
    450                 455                 460                 


Ala Asp Gln Leu Trp Thr Ser Tyr Gln Glu Leu Phe Lys Arg Ile Arg 
465                 470                 475                 480 


Gly Phe Lys Gly Ala Gln Val Lys Glu Tyr Ser Ser Gln Asn Ile Pro 
                485                 490                 495     


Ile Pro Ile Gln Lys Gln Ile Gln Asn Ile Leu Lys Pro Ala Glu Gln 
            500                 505                 510         


Val Thr Cys Phe Thr Lys Leu Met Tyr Leu Leu Thr Met Phe Leu Asp 
        515                 520                 525             


Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp 
    530                 535                 540                 


Asn Ile Ser Ser Leu Leu Lys Thr Met Glu Gln Leu Glu Leu Gln Thr 
545                 550                 555                 560 


Thr Phe Lys Glu Asp Tyr Thr Phe Phe Gln Gln Ser Ser Cys Leu Cys 
                565                 570                 575     


Glu Glu Ile Thr Gln Leu Lys Ser Phe Ala Arg Met Gly Asn Pro Ile 
            580                 585                 590         


Ser Asn Leu Lys Glu Val Met Met Val Asp Ala Ile Gln Ile Leu Gly 
        595                 600                 605             


Thr Glu Lys Ser Glu Gln Glu Leu Gln Ser Met Ala Cys Phe Phe Phe 
    610                 615                 620                 


Arg Asp Lys Asn Gly Lys Lys Leu Asn Ala Gly Glu His Gly Met Arg 
625                 630                 635                 640 


Asn Phe Ile Gly Asn Asn Val Ile Ser Asn Thr Arg Phe Gln Tyr Leu 
                645                 650                 655     


Ile Arg Tyr Gly Asn Pro Gln Lys Leu His Thr Leu Ser Gln Asn Glu 
            660                 665                 670         


Thr Val Val Arg Phe Val Leu Ser Arg Ile Ala Lys Asn Gln Arg Val 
        675                 680                 685             


Gln Gly Met Asn Gly Lys Asn Gln Ile Asp Arg Tyr Tyr Glu Thr Cys 
    690                 695                 700                 


Gly Gly Thr Asn Ser Trp Ser Val Ser Glu Glu Glu Lys Ile Asn Phe 
705                 710                 715                 720 


Leu Cys Lys Ile Leu Thr Asn Met Ser Tyr Asp Gln Phe Gln Asp Val 
                725                 730                 735     


Lys Gln Ser Asp Lys Ile Ile Thr Ala Glu Glu Lys Arg Lys Lys Glu 
            740                 745                 750         


Arg Tyr Lys Ala Ile Ile Ser Leu Tyr Leu Thr Val Leu Tyr Gln Leu 
        755                 760                 765             


Ile Lys Asn Leu Val Asn Ile Asn Ala Arg Tyr Ile Ile Ala Phe His 
    770                 775                 780                 


Cys Leu Glu Arg Asp Ala Ile Leu Tyr Ser Leu Lys Phe Asn Thr Ser 
785                 790                 795                 800 


Ile Asn Leu Lys Lys Arg Tyr Thr Ala Leu Thr Glu Met Ile Leu Gly 
                805                 810                 815     


Tyr Glu Thr Asp Glu Lys Ala Arg Arg Lys Asp Thr Arg Thr Ile Tyr 
            820                 825                 830         


Glu Lys Ala Glu Ala Ala Lys Asn Arg His Leu Lys Asn Val Lys Trp 
        835                 840                 845             


Asn Cys Lys Thr Arg Glu Asn Leu Glu Asn Ala Asp Lys Asn Ala Ile 
    850                 855                 860                 


Val Ala Phe Arg Asn Ile Val Ala His Leu Trp Ile Ile Arg Asp Ala 
865                 870                 875                 880 


Asp Arg Phe Ile Thr Glu Met Gly Ala Met Lys Arg Tyr Phe Asp Cys 
                885                 890                 895     


Tyr His Tyr Leu Leu Gln Arg Glu Leu Glu Tyr Ile Leu Glu Lys Ser 
            900                 905                 910         


Asn Gln Gly Ser Lys Tyr Thr Lys Lys Ser Leu Glu Lys Val Gln Gln 
        915                 920                 925             


Tyr His Ser Tyr Cys Lys Asp Phe Leu His Met Leu Cys Leu Pro Phe 
    930                 935                 940                 


Ala Tyr Cys Ile Pro Arg Tyr Lys Asn Leu Ser Ile Ala Glu Leu Phe 
945                 950                 955                 960 


Asp Arg His Glu Leu Glu Ala Glu Pro Lys Glu Glu Ala Ser Pro Ala 
                965                 970                 975     


Asn Asn Ser Gln Phe Ile Thr Thr 
            980                 


<210>  2920
<211>  956
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2920

Met Ala Lys Lys Lys Arg Ile Thr Ala Lys Glu Arg Lys Gln Asn His 
1               5                   10                  15      


Arg Glu Ser Leu Met Lys Lys Ala Asp Ser Asn Ala Glu Lys Glu Lys 
            20                  25                  30          


Ala Lys Lys Pro Val Val Glu Asn Lys Pro Asp Thr Ala Ile Ser Lys 
        35                  40                  45              


Asp Asn Thr Pro Lys Pro Asn Lys Glu Ile Lys Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Ala Gly Val Lys Trp Val Ile Lys Ala Asn Asp Asp Val Ala Tyr 
65                  70                  75                  80  


Ile Ser Ser Phe Gly Lys Gly Asn Asn Ser Val Leu Glu Lys Arg Ile 
                85                  90                  95      


Ile Gly Asp Val Ser Ser Asp Val Asn Lys Asp Ser His Met Tyr Val 
            100                 105                 110         


Asn Pro Lys Tyr Thr Lys Lys Asn Tyr Glu Ile Lys Asn Gly Phe Ser 
        115                 120                 125             


Ser Gly Ser Ser Leu Thr Thr His Pro Asn Lys Pro Asp Lys Asn Ser 
    130                 135                 140                 


Gly Met Asp Ala Leu Cys Leu Lys Ile Tyr Phe Glu Lys Glu Ile Phe 
145                 150                 155                 160 


Lys Asp Lys Phe Asn Asp Asn Met His Ile Gln Thr Ile Tyr Asn Ile 
                165                 170                 175     


Phe Asp Ile Glu Lys Thr Leu Ala Lys His Ile Thr Asn Ile Ile Tyr 
            180                 185                 190         


Ala Val Asn Ser Leu Asp Arg Ser Tyr Ile Gln Ser Gly Asn Asp Thr 
        195                 200                 205             


Ile Gly Phe Gly Leu Asn Tyr Arg Ile Pro Tyr Ala Lys Tyr Gly Arg 
    210                 215                 220                 


Gly Lys Asp Ser Asn Gly Lys Pro Asn Asn Ser Asn Leu Lys Lys Arg 
225                 230                 235                 240 


Glu Ser Phe Ile Lys Phe Tyr Asn Asn Ala Lys Asp Arg Phe Gly Tyr 
                245                 250                 255     


Phe Glu Ser Val Phe Tyr Gln Asn Gly Lys Pro Ile Ser Arg Glu Lys 
            260                 265                 270         


Leu Tyr Ile Tyr Leu Asn Ile Leu Asn Phe Val Arg Asn Ser Thr Phe 
        275                 280                 285             


His Tyr Asn Asn Thr Ser Thr Tyr Leu Tyr Arg Lys Glu Tyr Lys Tyr 
    290                 295                 300                 


Thr Asp Lys Asp Asn Cys Ser Val Lys Glu Phe Glu Phe Val Ser Tyr 
305                 310                 315                 320 


Leu Asn Glu Phe Val Lys Asn Lys Phe Lys Asn Val Asn Lys Asn Phe 
                325                 330                 335     


Ile Ser Asn Glu Lys Asn Asn Leu Tyr Ile Ile Leu Asn Ala Tyr Gly 
            340                 345                 350         


Glu Asp Ile Glu Asp Val Glu Val Val Lys Lys Tyr Ser Lys Glu Leu 
        355                 360                 365             


Tyr Lys Leu Ser Val Leu Lys Thr Asn Lys Asn Leu Gly Val Asn Val 
    370                 375                 380                 


Lys Lys Leu Arg Glu Ser Ala Ile Glu Tyr Gly Tyr Cys Pro Leu Pro 
385                 390                 395                 400 


Tyr Asp Lys Glu Lys Glu Val Ala Lys Leu Ser Ser Ile Lys His Lys 
                405                 410                 415     


Leu Tyr Lys Thr Tyr Asp Phe Val Ile Thr His Tyr Leu Asn Ser Asn 
            420                 425                 430         


Asp Lys Leu Leu Leu Glu Ile Val Glu Ala Leu Arg Leu Ser Lys Asn 
        435                 440                 445             


Asp Asp Glu Lys Glu Asn Val Tyr Lys Ile Tyr Ala Glu Lys Ile Phe 
    450                 455                 460                 


Lys Ala Glu Tyr Val Ile Asn Pro Ile Lys Thr Ile Ser Asn Leu Phe 
465                 470                 475                 480 


Ala Glu Lys Gly Asp Lys Leu Phe Asn Glu Lys Val Ser Ile Ser Glu 
                485                 490                 495     


Glu Tyr Val Glu Asp Ile Arg Ile Asp Lys Asn Ile His Asn Phe Thr 
            500                 505                 510         


Lys Val Ile Phe Phe Leu Thr Cys Phe Leu Asp Gly Lys Glu Ile Asn 
        515                 520                 525             


Asp Leu Leu Thr Asn Ile Ile Ser Lys Leu Gln Val Ile Glu Asp His 
    530                 535                 540                 


Asn Asn Val Ile Lys Ala Ile Ala Asn Asn Asn Asp Ala Val Tyr Lys 
545                 550                 555                 560 


Asp Tyr Ser Asp Lys Tyr Ala Val Phe Lys Asn Ser Gly Lys Ile Ala 
                565                 570                 575     


Thr Lys Leu Glu Ala Ile Lys Ser Ile Ala Arg Met Glu Asn Lys Ile 
            580                 585                 590         


Asn Lys Ala Phe Lys Glu Pro Leu Leu Lys Asp Ala Met Leu Ala Leu 
        595                 600                 605             


Gly Val Ser Pro Asn Asp Leu Asp Glu Lys Tyr Glu Lys Tyr Phe Lys 
    610                 615                 620                 


Thr Asp Val Asp Ala Asp Lys Asp His Gln Lys Val Ser Thr Phe Leu 
625                 630                 635                 640 


Met Asn Asn Val Ile Asn Asn Ser Arg Phe Lys Tyr Val Val Lys Tyr 
                645                 650                 655     


Ile Asn Pro Ala Asp Ile Asn Arg Leu Ala Lys Asn Lys His Leu Val 
            660                 665                 670         


Lys Phe Val Leu Asp Gln Ile Pro His Lys Gln Ile Asp Ser Tyr Tyr 
        675                 680                 685             


Asn Ser Val Cys Thr Val Glu Glu Pro Ser Tyr Lys Gly Lys Ile Gln 
    690                 695                 700                 


Leu Leu Thr Lys Lys Ile Thr Gly Leu Asn Phe Tyr Ser Leu Phe Glu 
705                 710                 715                 720 


Asn Cys Lys Ile Pro Asn Val Glu Lys Glu Lys Lys Lys Ala Val Ile 
                725                 730                 735     


Thr Leu Tyr Phe Thr Ile Ile Tyr Ile Leu Val Lys Asn Leu Val Asn 
            740                 745                 750         


Ile Asn Gly Leu Tyr Thr Leu Ala Leu Tyr Phe Val Glu Arg Asp Gly 
        755                 760                 765             


Phe Phe Tyr Lys Lys Ile Cys Glu Lys Lys Asp Lys Lys Lys Thr Asn 
    770                 775                 780                 


Lys Asp Val Asp Tyr Leu Leu Leu Pro Glu Ile Phe Ser Gly Ser Lys 
785                 790                 795                 800 


Tyr Arg Glu Glu Thr Lys Asn Leu Lys Leu Pro Lys Glu Lys Asp Arg 
                805                 810                 815     


Glu Ile Met Lys Lys Tyr Leu Pro Asn Asp Glu Asp Arg Lys Glu Tyr 
            820                 825                 830         


Asn Lys Phe Phe Lys Gln Tyr Arg Asn Asn Ile Val His Leu Asn Ile 
        835                 840                 845             


Ile Ala Asn Leu Ser Lys Leu Thr Ser Thr Ile Asp Lys Glu Ile Asn 
    850                 855                 860                 


Ser Tyr Phe Glu Ile Phe His Tyr Cys Ala Gln Arg Val Met Phe Asp 
865                 870                 875                 880 


Tyr Cys Lys Asn Asn Asn Lys Val Val Leu Ala Lys Met Lys Asp Leu 
                885                 890                 895     


Ala His Ile Lys Ser Asp Cys Asp Glu Phe Ser Ser Lys Tyr Thr Tyr 
            900                 905                 910         


Pro Tyr Ser Ser Ala Val Leu Arg Phe Met Asn Leu Pro Phe Ala Tyr 
        915                 920                 925             


Asn Val Pro Arg Phe Lys Asn Leu Ser Tyr Gln Lys Phe Phe Asp Lys 
    930                 935                 940                 


Gln Arg Leu Glu Ala Leu Glu Lys Asn Leu Asn Ile 
945                 950                 955     


<210>  2921
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2921

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asn Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Gln Asn Thr Tyr Tyr Ile Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Ile Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Asp Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Thr Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Glu Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2922
<211>  920
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2922

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Val Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Val Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asn Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Gly Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr Asn 
    210                 215                 220                 


Pro Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Asp Asp Tyr 
            340                 345                 350         


Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys 
        355                 360                 365             


Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met 
    370                 375                 380                 


Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val 
385                 390                 395                 400 


Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr 
                405                 410                 415     


Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg 
            420                 425                 430         


Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Thr Tyr Ala Asp Glu Ala 
        435                 440                 445             


Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp 
    450                 455                 460                 


His Met Asn Gly Asp Ala Ile Lys Glu Leu Gly Lys Ala Asp Met Asp 
465                 470                 475                 480 


Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu 
                485                 490                 495     


Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly 
            500                 505                 510         


Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn 
        515                 520                 525             


Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu 
    530                 535                 540                 


Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile 
545                 550                 555                 560 


Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro 
                565                 570                 575     


Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu 
            580                 585                 590         


Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys 
        595                 600                 605             


Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr 
    610                 615                 620                 


Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala 
625                 630                 635                 640 


Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met 
                645                 650                 655     


Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys 
            660                 665                 670         


Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg 
        675                 680                 685             


Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys 
    690                 695                 700                 


Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg 
705                 710                 715                 720 


Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val 
                725                 730                 735     


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys 
            740                 745                 750         


Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala 
        755                 760                 765             


Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys 
    770                 775                 780                 


Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg 
785                 790                 795                 800 


Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met 
                805                 810                 815     


Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu 
            820                 825                 830         


Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser 
        835                 840                 845             


Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp 
    850                 855                 860                 


Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn 
865                 870                 875                 880 


His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly 
                885                 890                 895     


Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp 
            900                 905                 910         


Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920 


<210>  2923
<211>  923
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2923

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Val Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Glu Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asn Ser Ser Asn Ile Glu Leu Arg Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Lys Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Ser Lys Leu His Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Asp Asp Tyr 
            340                 345                 350         


Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys 
        355                 360                 365             


Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met 
    370                 375                 380                 


Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val 
385                 390                 395                 400 


Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr 
                405                 410                 415     


Tyr Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg 
            420                 425                 430         


Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala 
        435                 440                 445             


Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp 
    450                 455                 460                 


His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp 
465                 470                 475                 480 


Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu 
                485                 490                 495     


Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly 
            500                 505                 510         


Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn 
        515                 520                 525             


Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu 
    530                 535                 540                 


Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile 
545                 550                 555                 560 


Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro 
                565                 570                 575     


Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu 
            580                 585                 590         


Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys 
        595                 600                 605             


Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr 
    610                 615                 620                 


Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala 
625                 630                 635                 640 


Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met 
                645                 650                 655     


Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys 
            660                 665                 670         


Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg 
        675                 680                 685             


Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys 
    690                 695                 700                 


Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg 
705                 710                 715                 720 


Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val 
                725                 730                 735     


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys 
            740                 745                 750         


Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala 
        755                 760                 765             


Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys 
    770                 775                 780                 


Glu Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys 
785                 790                 795                 800 


Asn Arg Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp 
                805                 810                 815     


Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Ile Thr Val 
            820                 825                 830         


Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser 
        835                 840                 845             


Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg 
    850                 855                 860                 


Glu Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu 
865                 870                 875                 880 


Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser 
                885                 890                 895     


Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln 
            900                 905                 910         


Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920             


<210>  2924
<211>  923
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2924

Met Phe Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Arg Arg Glu 
1               5                   10                  15      


Ala Gln Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn 
            20                  25                  30          


Ala Val Pro Ala Ile Ala Ala Met His Ala Ala Glu Val Ile Ala Pro 
        35                  40                  45              


Ala Ala Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser 
    50                  55                  60                  


Ile Leu Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly 
65                  70                  75                  80  


Asn Ser Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln 
                85                  90                  95      


Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Gly Val 
            100                 105                 110         


Thr Lys Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly 
        115                 120                 125             


Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser 
    130                 135                 140                 


Pro Val Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg 
145                 150                 155                 160 


Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr 
                165                 170                 175     


Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile 
            180                 185                 190         


Val Tyr Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr 
        195                 200                 205             


Asp Phe Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr 
    210                 215                 220                 


Asn Pro Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg 
225                 230                 235                 240 


Lys Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly 
                245                 250                 255     


Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu 
            260                 265                 270         


Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile 
        275                 280                 285             


Arg Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu 
    290                 295                 300                 


Tyr Ser Phe Ile Asn Asn Ile Tyr Pro Glu Tyr Arg Asp Thr Leu Asp 
305                 310                 315                 320 


Tyr Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Gln 
                325                 330                 335     


Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr 
            340                 345                 350         


Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys 
        355                 360                 365             


Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met 
    370                 375                 380                 


Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val 
385                 390                 395                 400 


Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr 
                405                 410                 415     


Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg 
            420                 425                 430         


Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala 
        435                 440                 445             


Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp 
    450                 455                 460                 


His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp 
465                 470                 475                 480 


Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu 
                485                 490                 495     


Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly 
            500                 505                 510         


Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn 
        515                 520                 525             


Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu 
    530                 535                 540                 


Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile 
545                 550                 555                 560 


Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro 
                565                 570                 575     


Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu 
            580                 585                 590         


Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys 
        595                 600                 605             


Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr 
    610                 615                 620                 


Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala 
625                 630                 635                 640 


Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met 
                645                 650                 655     


Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys 
            660                 665                 670         


Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg 
        675                 680                 685             


Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys 
    690                 695                 700                 


Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg 
705                 710                 715                 720 


Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val 
                725                 730                 735     


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys 
            740                 745                 750         


Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala 
        755                 760                 765             


Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys 
    770                 775                 780                 


Glu Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys 
785                 790                 795                 800 


Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp 
                805                 810                 815     


Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val 
            820                 825                 830         


Val Arg Glu Leu Lys Lys Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser 
        835                 840                 845             


Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg 
    850                 855                 860                 


Glu Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu 
865                 870                 875                 880 


Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser 
                885                 890                 895     


Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln 
            900                 905                 910         


Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920             


<210>  2925
<211>  956
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2925

Met Ala Lys Lys Lys Arg Ile Thr Ala Lys Glu Arg Lys Gln Asn His 
1               5                   10                  15      


Arg Glu Ser Leu Met Lys Lys Ala Asp Ser Asn Ala Glu Lys Glu Lys 
            20                  25                  30          


Ala Lys Lys Pro Val Val Glu Asn Lys Pro Asp Thr Ala Ile Ser Lys 
        35                  40                  45              


Asp Asn Thr Pro Lys Pro Asn Lys Glu Ile Lys Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Ala Gly Val Lys Trp Val Ile Lys Ala Asn Asp Asp Val Ala Tyr 
65                  70                  75                  80  


Ile Ser Ser Phe Gly Lys Gly Asn Asn Ser Val Leu Glu Lys Arg Ile 
                85                  90                  95      


Ile Gly Asp Val Ser Ser Asp Val Asn Lys Asp Ser His Met Tyr Val 
            100                 105                 110         


Asn Pro Lys Tyr Thr Lys Lys Asn Tyr Glu Ile Lys Asn Gly Phe Ser 
        115                 120                 125             


Ser Gly Ser Ser Leu Thr Thr His Pro Asn Lys Pro Asp Lys Asn Ser 
    130                 135                 140                 


Gly Met Asp Ala Leu Cys Leu Lys Ile Tyr Phe Glu Lys Glu Ile Phe 
145                 150                 155                 160 


Lys Asp Lys Phe Asn Asp Asn Met His Ile Gln Thr Ile Tyr Asn Ile 
                165                 170                 175     


Phe Asp Ile Glu Lys Thr Leu Ala Lys His Ile Thr Asn Ile Ile Tyr 
            180                 185                 190         


Ala Val Asn Ser Leu Asp Arg Ser Tyr Ile Gln Ser Gly Asn Asp Thr 
        195                 200                 205             


Ile Gly Phe Gly Leu Asn Tyr Arg Ile Pro Tyr Ala Lys Tyr Gly Arg 
    210                 215                 220                 


Gly Lys Asp Ser Asn Gly Lys Pro Asn Asn Ser Asn Leu Lys Lys Arg 
225                 230                 235                 240 


Glu Ser Phe Ile Lys Phe Tyr Asn Asn Ala Lys Asp Arg Phe Gly Tyr 
                245                 250                 255     


Phe Glu Ser Val Phe Tyr Gln Asn Gly Lys Pro Ile Ser Arg Glu Lys 
            260                 265                 270         


Leu Tyr Ile Tyr Leu Asn Ile Leu Asn Phe Val Arg Asn Ser Thr Phe 
        275                 280                 285             


His Tyr Asn Asn Thr Ser Thr Tyr Leu Tyr Arg Lys Glu Tyr Lys Tyr 
    290                 295                 300                 


Thr Asp Lys Asp Asn Cys Ser Val Lys Glu Phe Glu Phe Val Ser Tyr 
305                 310                 315                 320 


Leu Asn Glu Phe Val Lys Asn Lys Phe Lys Asn Val Asn Lys Asn Phe 
                325                 330                 335     


Ile Ser Asn Glu Lys Asn Asn Leu Tyr Ile Ile Leu Asn Ala Tyr Gly 
            340                 345                 350         


Glu Asp Ile Glu Asp Val Glu Val Val Lys Lys Tyr Ser Lys Glu Leu 
        355                 360                 365             


Tyr Lys Leu Ser Val Leu Lys Thr Asn Lys Asn Leu Gly Val Asn Val 
    370                 375                 380                 


Lys Lys Leu Arg Glu Ser Ala Ile Glu Tyr Gly Tyr Cys Pro Leu Pro 
385                 390                 395                 400 


Tyr Asp Lys Glu Lys Glu Val Ala Lys Leu Ser Ser Ile Lys His Lys 
                405                 410                 415     


Leu Tyr Lys Thr Tyr Asp Phe Val Ile Thr His Tyr Leu Asn Ser Asn 
            420                 425                 430         


Asp Lys Leu Leu Leu Glu Ile Val Glu Ala Leu Arg Leu Ser Lys Asn 
        435                 440                 445             


Asp Asp Glu Lys Glu Asn Val Tyr Lys Ile Tyr Ala Glu Lys Ile Phe 
    450                 455                 460                 


Lys Ala Glu Tyr Val Ile Asn Pro Ile Lys Thr Ile Ser Asn Leu Phe 
465                 470                 475                 480 


Ala Glu Lys Gly Asp Lys Leu Phe Asn Glu Lys Val Ser Ile Ser Glu 
                485                 490                 495     


Glu Tyr Val Glu Asp Ile Arg Ile Asp Lys Asn Ile His Asn Phe Thr 
            500                 505                 510         


Lys Val Ile Phe Phe Leu Thr Cys Phe Leu Asp Gly Lys Glu Ile Asn 
        515                 520                 525             


Asp Leu Leu Thr Asn Ile Ile Ser Lys Leu Gln Val Ile Glu Asp His 
    530                 535                 540                 


Asn Asn Val Ile Lys Ala Ile Ala Asn Asn Asn Asp Ala Val Tyr Lys 
545                 550                 555                 560 


Asp Tyr Ser Asp Lys Tyr Ala Val Phe Lys Asn Ser Gly Lys Ile Ala 
                565                 570                 575     


Thr Lys Leu Glu Ala Ile Lys Ser Ile Ala Arg Met Glu Asn Lys Ile 
            580                 585                 590         


Asn Lys Ala Phe Lys Glu Pro Leu Leu Lys Asp Ala Met Leu Ala Leu 
        595                 600                 605             


Gly Val Ser Pro Asn Asp Leu Asp Glu Lys Tyr Glu Lys Tyr Phe Lys 
    610                 615                 620                 


Thr Asp Val Asp Ala Asp Lys Asp His Gln Lys Val Ser Thr Phe Leu 
625                 630                 635                 640 


Met Asn Asn Val Ile Asn Asn Ser Arg Phe Lys Tyr Val Val Lys Tyr 
                645                 650                 655     


Ile Asn Pro Ala Asp Ile Asn Arg Leu Ala Lys Asn Lys His Leu Val 
            660                 665                 670         


Lys Phe Val Leu Asp Gln Ile Pro His Lys Gln Ile Asp Ser Tyr Tyr 
        675                 680                 685             


Asn Ser Val Cys Thr Val Glu Glu Pro Ser Tyr Lys Gly Lys Ile Gln 
    690                 695                 700                 


Leu Leu Thr Lys Lys Ile Thr Gly Leu Asn Phe Tyr Ser Leu Phe Glu 
705                 710                 715                 720 


Asn Cys Lys Ile Pro Asn Val Glu Lys Glu Lys Lys Lys Ala Val Ile 
                725                 730                 735     


Thr Leu Tyr Phe Thr Ile Ile Tyr Ile Leu Val Lys Asn Leu Val Asn 
            740                 745                 750         


Ile Asn Gly Leu Tyr Thr Leu Ala Leu Tyr Phe Val Glu Arg Asp Gly 
        755                 760                 765             


Phe Phe Tyr Lys Lys Ile Cys Glu Lys Lys Asp Lys Lys Lys Thr Asn 
    770                 775                 780                 


Lys Asp Val Asp Tyr Leu Leu Leu Pro Glu Ile Phe Ser Gly Ser Lys 
785                 790                 795                 800 


Tyr Arg Glu Glu Thr Lys Asn Leu Lys Leu Pro Lys Glu Lys Asp Arg 
                805                 810                 815     


Glu Ile Met Lys Lys Tyr Leu Pro Asn Asp Glu Asp Arg Lys Glu Tyr 
            820                 825                 830         


Asn Lys Phe Phe Lys Gln Tyr Arg Asn Asn Ile Val His Leu Asn Ile 
        835                 840                 845             


Ile Ala Asn Leu Ser Lys Leu Thr Ser Thr Ile Asp Lys Glu Ile Asn 
    850                 855                 860                 


Ser Tyr Phe Glu Ile Phe His Tyr Cys Ala Gln Arg Val Met Phe Asp 
865                 870                 875                 880 


Tyr Cys Lys Asn Asn Asn Lys Val Val Leu Ala Lys Met Lys Asp Leu 
                885                 890                 895     


Ala His Ile Lys Ser Asp Cys Asp Glu Phe Ser Ser Lys Tyr Thr Tyr 
            900                 905                 910         


Pro Tyr Ser Ser Ala Val Leu Arg Phe Met Asn Leu Pro Phe Ala Tyr 
        915                 920                 925             


Asn Val Pro Arg Phe Lys Asn Leu Ser Tyr Gln Lys Phe Phe Asp Lys 
    930                 935                 940                 


Gln Arg Leu Glu Ala Leu Glu Lys Asn Leu Asn Ile 
945                 950                 955     


<210>  2926
<211>  956
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2926

Met Ala Lys Lys Lys Arg Ile Thr Ala Lys Glu Arg Lys Gln Asn His 
1               5                   10                  15      


Arg Glu Ser Leu Met Lys Lys Ala Asp Ser Asn Ala Glu Lys Glu Lys 
            20                  25                  30          


Ala Lys Lys Pro Val Val Glu Asn Lys Pro Asp Thr Ala Ile Ser Lys 
        35                  40                  45              


Asp Asn Thr Pro Lys Pro Asn Lys Glu Ile Lys Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Ala Gly Val Lys Trp Val Ile Lys Ala Asn Asp Asp Val Ala Tyr 
65                  70                  75                  80  


Ile Ser Ser Phe Gly Lys Gly Asn Asn Ser Val Leu Glu Lys Arg Ile 
                85                  90                  95      


Ile Gly Asp Val Ser Ser Asp Val Asn Lys Asp Ser His Met Tyr Val 
            100                 105                 110         


Asn Pro Lys Tyr Thr Lys Lys Asn Tyr Glu Ile Lys Asn Gly Phe Ser 
        115                 120                 125             


Ser Gly Ser Ser Leu Thr Thr His Pro Asn Lys Pro Asp Lys Asn Ser 
    130                 135                 140                 


Gly Met Asp Ala Leu Cys Leu Lys Ile Tyr Phe Glu Lys Glu Ile Phe 
145                 150                 155                 160 


Lys Asp Lys Phe Asn Asp Asn Met His Ile Gln Thr Ile Tyr Asn Ile 
                165                 170                 175     


Phe Asp Ile Glu Lys Thr Leu Ala Lys His Ile Thr Asn Ile Ile Tyr 
            180                 185                 190         


Ala Val Asn Ser Leu Asp Arg Ser Tyr Ile Gln Ser Gly Asn Asp Thr 
        195                 200                 205             


Ile Gly Phe Gly Leu Asn Tyr Arg Ile Pro Tyr Ala Lys Tyr Gly Arg 
    210                 215                 220                 


Gly Lys Asp Ser Asn Gly Lys Pro Asn Asn Ser Asn Leu Lys Lys Arg 
225                 230                 235                 240 


Glu Ser Phe Ile Lys Phe Tyr Asn Asn Ala Lys Asp Arg Phe Gly Tyr 
                245                 250                 255     


Phe Glu Ser Val Phe Tyr Gln Asn Gly Lys Pro Ile Ser Arg Glu Lys 
            260                 265                 270         


Leu Tyr Ile Tyr Leu Asn Ile Leu Asn Phe Val Arg Asn Ser Thr Phe 
        275                 280                 285             


His Tyr Asn Asn Thr Ser Thr Tyr Leu Tyr Arg Lys Glu Tyr Lys Tyr 
    290                 295                 300                 


Thr Asp Lys Asp Asn Cys Ser Val Lys Glu Phe Glu Phe Val Ser Tyr 
305                 310                 315                 320 


Leu Asn Glu Phe Val Lys Asn Lys Phe Lys Asn Val Asn Lys Asn Phe 
                325                 330                 335     


Ile Ser Asn Glu Lys Asn Asn Leu Tyr Ile Ile Leu Asn Ala Tyr Gly 
            340                 345                 350         


Glu Asp Ile Glu Asp Val Glu Val Val Lys Lys Tyr Ser Lys Glu Leu 
        355                 360                 365             


Tyr Lys Leu Ser Val Leu Lys Thr Asn Lys Asn Leu Gly Val Asn Val 
    370                 375                 380                 


Lys Lys Leu Arg Glu Ser Ala Ile Glu Tyr Gly Tyr Cys Pro Leu Pro 
385                 390                 395                 400 


Tyr Asp Lys Glu Lys Glu Val Ala Lys Leu Ser Ser Ile Lys His Lys 
                405                 410                 415     


Leu Tyr Lys Thr Tyr Asp Phe Val Ile Thr His Tyr Leu Asn Ser Asn 
            420                 425                 430         


Asp Lys Leu Leu Leu Glu Ile Val Glu Ala Leu Arg Leu Ser Lys Asn 
        435                 440                 445             


Asp Asp Glu Lys Glu Asn Val Tyr Lys Ile Tyr Ala Glu Lys Ile Phe 
    450                 455                 460                 


Lys Ala Glu Tyr Val Ile Asn Pro Ile Lys Thr Ile Ser Asn Leu Phe 
465                 470                 475                 480 


Ala Glu Lys Gly Asp Lys Leu Phe Asn Glu Lys Val Ser Ile Ser Glu 
                485                 490                 495     


Glu Tyr Val Glu Asp Ile Arg Ile Asp Lys Asn Ile His Asn Phe Thr 
            500                 505                 510         


Lys Val Ile Phe Phe Leu Thr Cys Phe Leu Asp Gly Lys Glu Ile Asn 
        515                 520                 525             


Asp Leu Leu Thr Asn Ile Ile Ser Lys Leu Gln Val Ile Glu Asp His 
    530                 535                 540                 


Asn Asn Val Ile Lys Ala Ile Ala Asn Asn Asn Asp Ala Val Tyr Lys 
545                 550                 555                 560 


Asp Tyr Ser Asp Lys Tyr Ala Val Phe Lys Asn Ser Gly Lys Ile Ala 
                565                 570                 575     


Thr Lys Leu Glu Ala Ile Lys Ser Ile Ala Arg Met Glu Asn Lys Ile 
            580                 585                 590         


Asn Lys Ala Phe Lys Glu Pro Leu Leu Lys Asp Ala Met Leu Ala Leu 
        595                 600                 605             


Gly Val Ser Pro Asn Asp Leu Asp Glu Lys Tyr Glu Lys Tyr Phe Lys 
    610                 615                 620                 


Thr Asp Val Asp Ala Asp Lys Asp His Gln Lys Val Ser Thr Phe Leu 
625                 630                 635                 640 


Met Asn Asn Val Ile Asn Asn Ser Arg Phe Lys Tyr Val Val Lys Tyr 
                645                 650                 655     


Ile Asn Pro Ala Asp Ile Asn Arg Leu Ala Lys Asn Lys His Leu Val 
            660                 665                 670         


Lys Phe Val Leu Asp Gln Ile Pro His Lys Gln Ile Asp Ser Tyr Tyr 
        675                 680                 685             


Asn Ser Val Cys Thr Val Glu Glu Pro Ser Tyr Lys Gly Lys Ile Gln 
    690                 695                 700                 


Leu Leu Thr Lys Lys Ile Thr Gly Leu Asn Phe Tyr Ser Leu Phe Glu 
705                 710                 715                 720 


Asn Cys Lys Ile Pro Asn Val Glu Lys Glu Lys Lys Lys Ala Val Ile 
                725                 730                 735     


Thr Leu Tyr Phe Thr Ile Ile Tyr Ile Leu Val Lys Asn Leu Val Asn 
            740                 745                 750         


Ile Asn Gly Leu Tyr Thr Leu Ala Leu Tyr Phe Val Glu Arg Asp Gly 
        755                 760                 765             


Phe Phe Tyr Lys Lys Ile Cys Glu Lys Lys Asp Lys Lys Lys Thr Asn 
    770                 775                 780                 


Lys Asp Val Asp Tyr Leu Leu Leu Pro Glu Ile Phe Ser Gly Ser Lys 
785                 790                 795                 800 


Tyr Arg Glu Glu Thr Lys Asn Leu Lys Leu Pro Lys Glu Lys Asp Arg 
                805                 810                 815     


Glu Ile Met Lys Lys Tyr Leu Pro Asn Asp Glu Asp Arg Lys Glu Tyr 
            820                 825                 830         


Asn Lys Phe Phe Lys Gln Tyr Arg Asn Asn Ile Val His Leu Asn Ile 
        835                 840                 845             


Ile Ala Asn Leu Ser Lys Leu Thr Ser Thr Ile Asp Lys Glu Ile Asn 
    850                 855                 860                 


Ser Tyr Phe Glu Ile Phe His Tyr Cys Ala Gln Arg Val Met Phe Asp 
865                 870                 875                 880 


Tyr Cys Lys Asn Asn Asn Lys Val Val Leu Ala Lys Met Lys Asp Leu 
                885                 890                 895     


Ala His Ile Lys Ser Asp Cys Asp Glu Phe Ser Ser Lys Tyr Thr Tyr 
            900                 905                 910         


Pro Tyr Ser Ser Ala Val Leu Arg Phe Met Asn Leu Pro Phe Ala Tyr 
        915                 920                 925             


Asn Val Pro Arg Phe Lys Asn Leu Ser Tyr Gln Lys Phe Phe Asp Lys 
    930                 935                 940                 


Gln Arg Leu Glu Ala Leu Glu Lys Asn Leu Asn Ile 
945                 950                 955     


<210>  2927
<211>  975
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2927

Met Met Gly Lys His Leu Asn Ala Lys Gln Arg Glu Leu Glu Lys Lys 
1               5                   10                  15      


Leu Lys Asn Gln Gln Lys Gly Met Met Tyr Asn Lys Ser Thr Asp Ala 
            20                  25                  30          


Val Ser Val Pro Thr Leu Gln Ala Ala Pro Lys Lys Ala Ala Glu Ala 
        35                  40                  45              


Ser Thr Leu Ile Thr Pro Gly Thr Leu Lys Thr Lys Ala Lys Ala Met 
    50                  55                  60                  


Gly Leu Lys Ser Thr Leu Val Phe Asp Asp Lys Ile Val Val Thr Ser 
65                  70                  75                  80  


Phe Leu Asn Ser Lys Thr Glu Glu Asn Glu Lys Cys Ala His Ile Glu 
                85                  90                  95      


Lys Ile Thr Asp Cys Asn Gly Gln Thr Ile Val Glu Arg Pro Arg Met 
            100                 105                 110         


Phe Asn Thr Ser Ile Asn Ala Gln Gln Val Asp Leu Ser Lys Asp Asn 
        115                 120                 125             


Asp Glu Thr Asn Tyr Pro Asn Pro Ala Phe Glu Asp Cys Gly Arg Asp 
    130                 135                 140                 


Tyr Ile Asn Ile Lys Ser Ala Leu Glu Lys Arg Val Phe Gly Lys Thr 
145                 150                 155                 160 


Tyr Asn Lys Asp Asn Leu His Val Gln Ile Ala Tyr Asn Ile Phe Asp 
                165                 170                 175     


Ile Lys Lys Ile Ile Gly Thr Tyr Ile Asn Asn Ile Thr Tyr Ile Phe 
            180                 185                 190         


Tyr Asn Leu Gly Arg Glu Glu Tyr Asn Ala Lys Lys Asp Ile Ile Gly 
        195                 200                 205             


Asn Gln Asp Ser Asp Tyr Ile Asn Lys Leu Leu Asn Asn Thr Ser Ala 
    210                 215                 220                 


Tyr Phe Thr Tyr Phe Asp Gly Val Phe Lys Gln Ile Thr Asp Arg Asp 
225                 230                 235                 240 


Ser Asn Lys Asp Arg Glu Val Lys Asn Ser Tyr Asn Ala Leu Val Leu 
                245                 250                 255     


Lys Val Leu Tyr Tyr Leu Arg Gln Phe Cys Met His Gly Asn Thr Tyr 
            260                 265                 270         


Thr Lys Arg Asn Glu Glu Ser Phe Leu Ser Asp Thr Ala Leu Tyr Asn 
        275                 280                 285             


Val Lys Asp Phe Phe Ala Lys Ala Asp Pro Gln Ile Asn Glu Leu Ile 
    290                 295                 300                 


Asp Ala Val Tyr Ala Asp Gly Ile Lys Thr Ile Asn Asn Asp Phe Met 
305                 310                 315                 320 


Ala His Ala Lys Asn Asn Met Tyr Ile Ile Cys Glu Val Tyr Lys Asn 
                325                 330                 335     


Glu Val Glu Asp Ser Leu Met Lys Glu Tyr Tyr Asp Phe Val Val Arg 
            340                 345                 350         


Lys Glu Gly Asn Asn Leu Gly Phe Asn Thr Arg Gln Leu Arg Glu Ile 
        355                 360                 365             


Leu Ile Asp Lys Tyr Val Gly Asn Leu Arg Asp Lys Lys Tyr Asp Thr 
    370                 375                 380                 


Phe Arg Asn Lys Leu Tyr Thr Val Leu Gly Phe Ile Leu Val Lys Glu 
385                 390                 395                 400 


Ile Lys Arg Asn Pro Lys Ile Gln Asp Ser Phe Ile Ala Lys Leu Arg 
                405                 410                 415     


Ala Asn Gln Ser Gly Asp Glu Gly Lys Leu Asn Ile Tyr Asn Glu Phe 
            420                 425                 430         


Ala Pro Lys Ile Trp Ser Val Val Ser Ser Lys Phe Asn Ser Ala Ile 
        435                 440                 445             


Lys Cys Phe Asp Glu Glu Ser Leu Ser Lys Phe Lys Gly Tyr Lys Asp 
    450                 455                 460                 


Ile Asp Glu Ser Leu Ile Ser Lys Tyr Gly Ile Thr Val Ser Asn Thr 
465                 470                 475                 480 


Asp Thr Leu Val Lys Ile Leu Tyr Phe Leu Cys Lys Phe Leu Asp Gly 
                485                 490                 495     


Lys Glu Ile Asn Glu Leu Cys Cys Ala Met Ile Asn Lys Phe Asp Asn 
            500                 505                 510         


Ile Asn Asp Leu Ile Lys Thr Ala Ala Gln Cys Gly Glu Asp Ile Glu 
        515                 520                 525             


Phe Val Lys Glu Tyr Lys Leu Phe Ile Asn Ser Lys Asp Leu Ser Asp 
    530                 535                 540                 


Gln Ile Arg Val Val Lys Ser Ile Ser Lys Met Lys Pro Glu Leu Ser 
545                 550                 555                 560 


Asn Ile Gly Glu Val Leu Leu Leu Asp Ala Ile Asp Ile Leu Gly Tyr 
                565                 570                 575     


Lys Ile Asn Lys Tyr Lys Cys Asp Ala Asp Gly Asn Arg Leu Val Asp 
            580                 585                 590         


Ser Asn Asn Lys Pro Val Tyr Ser Glu Glu Tyr Cys Thr Phe Lys Lys 
        595                 600                 605             


Asp Phe Phe Glu Thr Cys Glu Leu Asp Glu Phe Gly Arg Val Lys Tyr 
    610                 615                 620                 


Asp Lys Lys Gly Lys Pro Val Ile Asn His Arg Arg Arg Asn Phe Ile 
625                 630                 635                 640 


Ile Asn Asn Val Leu Ser Ser Lys Trp Phe Phe Tyr Val Ala Lys Tyr 
                645                 650                 655     


Asn Arg Pro Ser Glu Cys Gln Lys Phe Met Lys Ser Lys Lys Leu Ile 
            660                 665                 670         


Ala Leu Ala Leu Lys Asp Val Pro Glu Thr Gln Ile Ala Arg Tyr Tyr 
        675                 680                 685             


His Ser Val Thr Gly Gly Arg Glu Gln Thr Asp Ser Glu Ala Met Arg 
    690                 695                 700                 


Thr Thr Leu Ile Ser Arg Leu His Glu Phe Ser Ile Lys Asp Val Leu 
705                 710                 715                 720 


Ser Ser Val Gly Ser Met Thr Ala Ser Glu Asn Lys Arg Gln Ile Glu 
                725                 730                 735     


Asn Ser Arg Lys Glu Gln Met Lys Ala Ile Val Lys Leu Tyr Leu Thr 
            740                 745                 750         


Val Val Tyr Leu Ile Ala Lys Ser Leu Val Lys Val Asn Thr Arg Phe 
        755                 760                 765             


Ser Ile Ala Phe Ser Ala Tyr Glu Arg Asp Val Ser Leu Leu Ala Asp 
    770                 775                 780                 


Glu Asn Glu Ser Ile Ala Met Ala Asp Asn Asp Asp Asp Lys Trp Lys 
785                 790                 795                 800 


Thr Gly Asn Tyr Ile Phe Ala Leu Thr Lys His Phe Leu Asp Asn Asp 
                805                 810                 815     


Glu Pro Tyr Phe Asp Lys Tyr Asn Asn Ala Leu Gln Gln Ile Lys Gly 
            820                 825                 830         


Ile Thr Asp Pro Asn Glu Arg Arg Leu Ala Tyr Arg Ala Asn Asp Lys 
        835                 840                 845             


Val Ile Lys His Thr His Phe Asn Leu His Thr Asn Lys Tyr Val Lys 
    850                 855                 860                 


Asp Asn Tyr Glu Lys Ile Ser Lys Met Asn Lys Ile Val Thr Glu Tyr 
865                 870                 875                 880 


Arg Asn Asn Val Gln His Leu Ala Val Val Asn Asn Ile Thr Lys Tyr 
                885                 890                 895     


Leu Gly Asp Ile Ser Glu Val Thr Ser Tyr Tyr Ser Leu Tyr Cys Tyr 
            900                 905                 910         


Ile Leu Gln Arg Leu Leu Leu Asp Asn Asn Asn Asn Asp Lys Phe Ala 
        915                 920                 925             


Glu Ile Lys Glu Lys Leu Ile Lys Phe Gly Thr Tyr Asn Lys Asp Phe 
    930                 935                 940                 


Met Trp Leu Ile Asn Val Pro Phe Ala Tyr Asn Leu Pro Arg Tyr Lys 
945                 950                 955                 960 


Asn Leu Ser Asn Glu Glu Ile Phe Tyr Asp Val Ile Gln Asn Lys 
                965                 970                 975 


<210>  2928
<211>  984
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2928

Met Lys Lys Lys Asn Ile Arg Ala Thr Arg Glu Ala Leu Lys Ala Gln 
1               5                   10                  15      


Lys Ile Lys Lys Ser Gln Glu Asn Glu Ala Leu Lys Lys Gln Lys Leu 
            20                  25                  30          


Ala Glu Glu Ala Ala Gln Lys Arg Arg Glu Glu Leu Glu Lys Lys Asn 
        35                  40                  45              


Leu Ala Gln Trp Glu Glu Thr Ser Ala Glu Gly Arg Arg Ser Arg Val 
    50                  55                  60                  


Lys Ala Val Gly Val Lys Ser Val Phe Val Val Gly Asp Asp Leu Tyr 
65                  70                  75                  80  


Leu Ala Thr Phe Gly Asn Gly Asn Glu Thr Val Leu Glu Lys Lys Ile 
                85                  90                  95      


Ala Pro Asp Gly Lys Ile Thr Thr Phe Pro Glu Glu Glu Thr Phe Thr 
            100                 105                 110         


Ala Lys Leu Lys Phe Ala Gln Thr Glu Pro Thr Glu Ala Thr Ser Ile 
        115                 120                 125             


Gly Ile Ser Asn Gly Arg Ile Val Leu Pro Glu Ile Ser Val Asp Asn 
    130                 135                 140                 


Pro Leu His Thr Thr Met Gln Lys Asn Thr Ile Lys Arg Ser Ala Gly 
145                 150                 155                 160 


Glu Asp Met Leu Gln Leu Lys Asn Val Leu Glu Asn Arg Tyr Phe Asp 
                165                 170                 175     


Arg Ser Phe Asn Asp Asp Leu His Ile Arg Leu Ile Tyr Asn Ile Leu 
            180                 185                 190         


Asp Ile Glu Lys Ile Leu Ala Glu Tyr Thr Thr Asn Ala Val Phe Ala 
        195                 200                 205             


Ile Asp Asn Val Ser Gly Cys Ser Asp Asp Phe Leu Ser Asn Phe Ser 
    210                 215                 220                 


Thr Arg Asn Gln Trp Asp Glu Phe Gln Asn Pro Glu Gln His Arg Glu 
225                 230                 235                 240 


His Phe Gly Asn Lys Asp Asn Val Ile Cys Ser Val Lys Lys Gln Gln 
                245                 250                 255     


Asp Leu Phe Phe Asn Phe Phe Lys Asn Asn Arg Ile Gly Tyr Phe Gly 
            260                 265                 270         


Lys Ala Phe Phe His Ala Glu Ser Glu Arg Lys Ile Val Lys Lys Thr 
        275                 280                 285             


Ala Lys Glu Val Tyr His Ile Leu Thr Leu Ile Gly Ser Leu Arg Gln 
    290                 295                 300                 


Trp Ile Thr His Ser Thr Glu Gly Gly Ile Ser Arg Leu Trp Leu Tyr 
305                 310                 315                 320 


Gln Leu Glu Asp Ala Leu Ser Ser Glu Tyr Gln Glu Thr Met Asn Asn 
                325                 330                 335     


Cys Tyr Asn Ser Thr Ile Tyr Gly Leu Gln Lys Asp Phe Glu Lys Thr 
            340                 345                 350         


Asn Ala Pro Asn Leu Asn Phe Leu Ala Glu Ile Leu Gly Lys Asn Ala 
        355                 360                 365             


Ser Glu Leu Ala Glu Pro Tyr Phe Arg Phe Ile Ile Thr Lys Glu Tyr 
    370                 375                 380                 


Lys Asn Leu Gly Phe Ser Ile Lys Thr Leu Arg Glu Met Leu Leu Asp 
385                 390                 395                 400 


Gln Pro Asp Leu Gln Glu Ile Arg Glu Asn His Asn Val Tyr Asp Ser 
                405                 410                 415     


Ile Arg Ser Lys Leu Tyr Lys Met Met Asp Phe Val Leu Val Tyr Ala 
            420                 425                 430         


Tyr Ser Asn Glu Arg Lys Ser Lys Ala Asp Ala Leu Ala Ser Asn Leu 
        435                 440                 445             


Arg Ser Ala Ile Thr Glu Asp Ala Lys Lys Arg Ile Tyr Gln Asn Glu 
    450                 455                 460                 


Ala Asp Gln Leu Trp Thr Ser Tyr Gln Glu Leu Phe Lys Arg Ile Arg 
465                 470                 475                 480 


Gly Phe Lys Gly Ala Gln Val Lys Glu Tyr Ser Ser Gln Asn Ile Pro 
                485                 490                 495     


Ile Pro Ile Gln Lys Gln Ile Gln Asn Ile Leu Lys Pro Ala Glu Gln 
            500                 505                 510         


Val Thr Cys Phe Thr Lys Leu Met Tyr Leu Leu Thr Met Phe Leu Asp 
        515                 520                 525             


Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp 
    530                 535                 540                 


Asn Ile Ser Ser Leu Leu Lys Thr Met Glu Gln Leu Glu Leu Gln Thr 
545                 550                 555                 560 


Thr Phe Lys Glu Asp Tyr Thr Phe Phe Gln Gln Ser Ser Cys Leu Cys 
                565                 570                 575     


Glu Glu Ile Thr Gln Leu Lys Ser Phe Ala Arg Met Gly Asn Pro Ile 
            580                 585                 590         


Ser Asn Leu Lys Glu Val Met Met Val Asp Ala Ile Gln Ile Leu Gly 
        595                 600                 605             


Thr Glu Lys Ser Glu Gln Glu Leu Gln Ser Met Ala Cys Phe Phe Phe 
    610                 615                 620                 


Arg Asp Lys Asn Gly Lys Lys Leu Asn Ala Gly Glu His Gly Met Arg 
625                 630                 635                 640 


Asn Phe Ile Gly Asn Asn Val Ile Ser Asn Thr Arg Phe Gln Tyr Leu 
                645                 650                 655     


Ile Arg Tyr Gly Asn Pro Gln Lys Leu His Thr Leu Ser Gln Asn Glu 
            660                 665                 670         


Thr Val Val Arg Phe Val Leu Ser Arg Ile Ala Lys Asn Gln Arg Val 
        675                 680                 685             


Gln Gly Met Asn Gly Lys Asn Gln Ile Asp Arg Tyr Tyr Glu Thr Cys 
    690                 695                 700                 


Gly Gly Thr Asn Ser Trp Ser Val Ser Glu Glu Glu Lys Ile Asn Phe 
705                 710                 715                 720 


Leu Cys Lys Ile Leu Thr Asn Met Ser Tyr Asp Gln Phe Gln Asp Val 
                725                 730                 735     


Lys Gln Ser Asp Lys Ile Ile Thr Ala Glu Glu Lys Arg Lys Lys Glu 
            740                 745                 750         


Arg Tyr Lys Ala Ile Ile Ser Leu Tyr Leu Thr Val Leu Tyr Gln Leu 
        755                 760                 765             


Ile Lys Asn Leu Val Asn Ile Asn Ala Arg Tyr Ile Ile Ala Phe His 
    770                 775                 780                 


Cys Leu Glu Arg Asp Ala Ile Leu Tyr Ser Leu Lys Phe Asn Thr Ser 
785                 790                 795                 800 


Ile Asn Leu Lys Lys Arg Tyr Thr Ala Leu Thr Glu Met Ile Leu Gly 
                805                 810                 815     


Tyr Glu Thr Asp Glu Lys Ala Arg Arg Lys Asp Thr Arg Thr Ile Tyr 
            820                 825                 830         


Glu Lys Ala Glu Ala Ala Lys Asn Arg His Leu Lys Asn Val Lys Trp 
        835                 840                 845             


Asn Cys Lys Thr Arg Glu Asn Leu Glu Asn Ala Asp Lys Asn Ala Ile 
    850                 855                 860                 


Val Ala Phe Arg Asn Ile Val Ala His Leu Trp Ile Ile Arg Asp Ala 
865                 870                 875                 880 


Asp Arg Phe Ile Thr Glu Met Gly Ala Met Lys Arg Tyr Phe Asp Cys 
                885                 890                 895     


Tyr His Tyr Leu Leu Gln Arg Glu Leu Glu Tyr Ile Leu Glu Lys Ser 
            900                 905                 910         


Asn Gln Gly Ser Lys Tyr Thr Lys Lys Ser Leu Glu Lys Val Gln Gln 
        915                 920                 925             


Tyr His Ser Tyr Cys Lys Asp Phe Leu His Met Leu Cys Leu Pro Phe 
    930                 935                 940                 


Ala Tyr Cys Ile Pro Arg Tyr Lys Asn Leu Ser Ile Ala Glu Leu Phe 
945                 950                 955                 960 


Asp Arg His Glu Leu Glu Ala Glu Pro Lys Glu Glu Ala Ser Pro Ala 
                965                 970                 975     


Asn Asn Ser Gln Phe Ile Thr Thr 
            980                 


<210>  2929
<211>  984
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2929

Met Lys Lys Lys Asn Ile Arg Ala Thr Arg Glu Ala Leu Lys Ala Gln 
1               5                   10                  15      


Lys Ile Lys Lys Ser Gln Glu Asn Glu Ala Leu Lys Lys Gln Lys Leu 
            20                  25                  30          


Ala Glu Glu Ala Ala Gln Lys Arg Arg Glu Glu Leu Glu Lys Lys Asn 
        35                  40                  45              


Leu Ala Gln Trp Glu Glu Thr Ser Ala Glu Gly Arg Arg Ser Arg Val 
    50                  55                  60                  


Lys Ala Val Gly Val Lys Ser Val Phe Val Val Gly Asp Asp Leu Tyr 
65                  70                  75                  80  


Leu Ala Thr Phe Gly Asn Gly Asn Glu Thr Val Leu Glu Lys Lys Ile 
                85                  90                  95      


Ala Pro Asp Gly Lys Ile Thr Thr Phe Pro Glu Glu Glu Thr Phe Thr 
            100                 105                 110         


Ala Lys Leu Lys Phe Ala Gln Thr Glu Pro Thr Glu Ala Thr Ser Ile 
        115                 120                 125             


Gly Ile Ser Asn Gly Arg Ile Val Leu Pro Glu Ile Ser Val Asp Asn 
    130                 135                 140                 


Pro Leu His Thr Thr Met Gln Lys Asn Thr Ile Lys Arg Ser Ala Gly 
145                 150                 155                 160 


Glu Asp Met Leu Gln Leu Lys Asn Val Leu Glu Asn Arg Tyr Phe Asp 
                165                 170                 175     


Arg Ser Phe Asn Asp Asp Leu His Ile Arg Leu Ile Tyr Asn Ile Leu 
            180                 185                 190         


Asp Ile Glu Lys Ile Leu Ala Glu Tyr Thr Thr Asn Ala Val Phe Ala 
        195                 200                 205             


Ile Asp Asn Val Ser Gly Cys Ser Asp Asp Phe Leu Ser Asn Phe Ser 
    210                 215                 220                 


Thr Arg Asn Gln Trp Asp Glu Phe Gln Asn Pro Glu Gln His Arg Glu 
225                 230                 235                 240 


His Phe Gly Asn Lys Asp Asn Val Ile Cys Ser Val Lys Lys Gln Gln 
                245                 250                 255     


Asp Leu Phe Phe Asn Phe Phe Lys Asn Asn Arg Ile Gly Tyr Phe Gly 
            260                 265                 270         


Lys Ala Phe Phe His Ala Glu Ser Glu Arg Lys Ile Val Lys Lys Thr 
        275                 280                 285             


Ala Lys Glu Val Tyr His Ile Leu Thr Leu Ile Gly Ser Leu Arg Gln 
    290                 295                 300                 


Trp Ile Thr His Ser Thr Glu Gly Gly Ile Ser Arg Leu Trp Leu Tyr 
305                 310                 315                 320 


Gln Leu Glu Asp Ala Leu Ser Ser Glu Tyr Gln Glu Thr Met Asn Asn 
                325                 330                 335     


Cys Tyr Asn Ser Thr Ile Tyr Gly Leu Gln Lys Asp Phe Glu Lys Thr 
            340                 345                 350         


Asn Ala Pro Asn Leu Asn Phe Leu Ala Glu Ile Leu Gly Lys Asn Ala 
        355                 360                 365             


Ser Glu Leu Ala Glu Pro Tyr Phe Arg Phe Ile Ile Thr Lys Glu Tyr 
    370                 375                 380                 


Lys Asn Leu Gly Phe Ser Ile Lys Thr Leu Arg Glu Met Leu Leu Asp 
385                 390                 395                 400 


Gln Pro Asp Leu Gln Glu Ile Arg Glu Asn His Asn Val Tyr Asp Ser 
                405                 410                 415     


Ile Arg Ser Lys Leu Tyr Lys Met Met Asp Phe Val Leu Val Tyr Ala 
            420                 425                 430         


Tyr Ser Asn Glu Arg Lys Ser Lys Ala Asp Ala Leu Ala Ser Asn Leu 
        435                 440                 445             


Arg Ser Ala Ile Thr Glu Asp Ala Lys Lys Arg Ile Tyr Gln Asn Glu 
    450                 455                 460                 


Ala Asp Gln Leu Trp Thr Ser Tyr Gln Glu Leu Phe Lys Arg Ile Arg 
465                 470                 475                 480 


Gly Phe Lys Gly Ala Gln Val Lys Glu Tyr Ser Ser Gln Asn Ile Pro 
                485                 490                 495     


Ile Pro Ile Gln Lys Gln Ile Gln Asn Ile Leu Lys Pro Ala Glu Gln 
            500                 505                 510         


Val Thr Cys Phe Thr Lys Leu Met Tyr Leu Leu Thr Met Phe Leu Asp 
        515                 520                 525             


Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp 
    530                 535                 540                 


Asn Ile Ser Ser Leu Leu Lys Thr Met Glu Gln Leu Glu Leu Gln Thr 
545                 550                 555                 560 


Thr Phe Lys Glu Asp Tyr Thr Phe Phe Gln Gln Ser Ser Cys Leu Cys 
                565                 570                 575     


Glu Glu Ile Thr Gln Leu Lys Ser Phe Ala Arg Met Gly Asn Pro Ile 
            580                 585                 590         


Ser Asn Leu Lys Glu Val Met Met Val Asp Ala Ile Gln Ile Leu Gly 
        595                 600                 605             


Thr Glu Lys Ser Glu Gln Glu Leu Gln Ser Met Ala Cys Phe Phe Phe 
    610                 615                 620                 


Arg Asp Lys Asn Gly Lys Lys Leu Asn Ala Gly Glu His Gly Met Arg 
625                 630                 635                 640 


Asn Phe Ile Gly Asn Asn Val Ile Ser Asn Thr Arg Phe Gln Tyr Leu 
                645                 650                 655     


Ile Arg Tyr Gly Asn Pro Gln Lys Leu His Thr Leu Ser Gln Asn Glu 
            660                 665                 670         


Thr Val Val Arg Phe Val Leu Ser Arg Ile Ala Lys Asn Gln Arg Val 
        675                 680                 685             


Gln Gly Met Asn Gly Lys Asn Gln Ile Asp Arg Tyr Tyr Glu Thr Cys 
    690                 695                 700                 


Gly Gly Thr Asn Ser Trp Ser Val Ser Glu Glu Glu Lys Ile Asn Phe 
705                 710                 715                 720 


Leu Cys Lys Ile Leu Thr Asn Met Ser Tyr Asp Gln Phe Gln Asp Val 
                725                 730                 735     


Lys Gln Ser Asp Lys Ile Ile Thr Ala Glu Glu Lys Arg Lys Lys Glu 
            740                 745                 750         


Arg Tyr Lys Ala Ile Ile Ser Leu Tyr Leu Thr Val Leu Tyr Gln Leu 
        755                 760                 765             


Ile Lys Asn Leu Val Asn Ile Asn Ala Arg Tyr Ile Ile Ala Phe His 
    770                 775                 780                 


Cys Leu Glu Arg Asp Ala Ile Leu Tyr Ser Leu Lys Phe Asn Thr Ser 
785                 790                 795                 800 


Ile Asn Leu Lys Lys Arg Tyr Thr Ala Leu Thr Glu Met Ile Leu Gly 
                805                 810                 815     


Tyr Glu Thr Asp Glu Lys Ala Arg Arg Lys Asp Thr Arg Thr Ile Tyr 
            820                 825                 830         


Glu Lys Ala Glu Ala Ala Lys Asn Arg His Leu Lys Asn Val Lys Trp 
        835                 840                 845             


Asn Cys Lys Thr Arg Glu Asn Leu Glu Asn Ala Asp Lys Asn Ala Ile 
    850                 855                 860                 


Val Ala Phe Arg Asn Ile Val Ala His Leu Trp Ile Ile Arg Asp Ala 
865                 870                 875                 880 


Asp Arg Phe Ile Thr Glu Met Gly Ala Met Lys Arg Tyr Phe Asp Cys 
                885                 890                 895     


Tyr His Tyr Leu Leu Gln Arg Glu Leu Glu Tyr Ile Leu Glu Lys Ser 
            900                 905                 910         


Asn Gln Gly Ser Lys Tyr Thr Lys Lys Ser Leu Glu Lys Val Gln Gln 
        915                 920                 925             


Tyr His Ser Tyr Cys Lys Asp Phe Leu His Met Leu Cys Leu Pro Phe 
    930                 935                 940                 


Ala Tyr Cys Ile Pro Arg Tyr Lys Asn Leu Ser Ile Ala Glu Leu Phe 
945                 950                 955                 960 


Asp Arg His Glu Leu Glu Ala Glu Pro Lys Glu Glu Ala Ser Pro Ala 
                965                 970                 975     


Asn Asn Ser Gln Phe Ile Thr Thr 
            980                 


<210>  2930
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2930

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Ile Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Pro Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn His Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2931
<211>  984
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2931

Met Lys Lys Lys Asn Ile Arg Ala Thr Arg Glu Ala Leu Lys Ala Gln 
1               5                   10                  15      


Lys Ile Lys Lys Ser Gln Glu Asn Glu Ala Leu Lys Lys Gln Lys Leu 
            20                  25                  30          


Ala Glu Glu Ala Ala Gln Lys Arg Arg Glu Glu Leu Glu Lys Lys Asn 
        35                  40                  45              


Leu Ala Gln Trp Glu Glu Thr Ser Ala Glu Gly Arg Arg Ser Arg Val 
    50                  55                  60                  


Lys Ala Val Gly Val Lys Ser Val Phe Val Val Gly Asp Asp Leu Tyr 
65                  70                  75                  80  


Leu Ala Thr Phe Gly Asn Gly Asn Glu Thr Val Leu Glu Lys Lys Ile 
                85                  90                  95      


Ala Pro Asp Gly Lys Ile Thr Thr Phe Pro Glu Glu Glu Thr Phe Thr 
            100                 105                 110         


Ala Lys Leu Lys Phe Ala Gln Thr Glu Pro Thr Glu Ala Thr Ser Ile 
        115                 120                 125             


Gly Ile Ser Asn Gly Arg Ile Val Leu Pro Glu Ile Ser Val Asp Asn 
    130                 135                 140                 


Pro Leu His Thr Thr Met Gln Lys Asn Thr Ile Lys Arg Ser Ala Gly 
145                 150                 155                 160 


Glu Asp Met Leu Gln Leu Lys Asn Val Leu Glu Asn Arg Tyr Phe Asp 
                165                 170                 175     


Arg Ser Phe Asn Asp Asp Leu His Ile Arg Leu Ile Tyr Asn Ile Leu 
            180                 185                 190         


Asp Ile Glu Lys Ile Leu Ala Glu Tyr Thr Thr Asn Ala Val Phe Ala 
        195                 200                 205             


Ile Asp Asn Val Ser Gly Cys Ser Asp Asp Phe Leu Ser Asn Phe Ser 
    210                 215                 220                 


Thr Arg Asn Gln Trp Asp Glu Phe Gln Asn Pro Glu Gln His Arg Glu 
225                 230                 235                 240 


His Phe Gly Asn Lys Asp Asn Val Ile Cys Ser Val Lys Lys Gln Gln 
                245                 250                 255     


Asp Leu Phe Phe Asn Phe Phe Lys Asn Asn Arg Ile Gly Tyr Phe Gly 
            260                 265                 270         


Lys Ala Phe Phe His Ala Glu Ser Glu Arg Lys Ile Val Lys Lys Thr 
        275                 280                 285             


Ala Lys Glu Val Tyr His Ile Leu Thr Leu Ile Gly Ser Leu Arg Gln 
    290                 295                 300                 


Trp Ile Thr His Ser Thr Glu Gly Gly Ile Ser Arg Leu Trp Leu Tyr 
305                 310                 315                 320 


Gln Leu Glu Asp Ala Leu Ser Ser Glu Tyr Gln Glu Thr Met Asn Asn 
                325                 330                 335     


Cys Tyr Asn Ser Thr Ile Tyr Gly Leu Gln Lys Asp Phe Glu Lys Thr 
            340                 345                 350         


Asn Ala Pro Asn Leu Asn Phe Leu Ala Glu Ile Leu Gly Lys Asn Ala 
        355                 360                 365             


Ser Glu Leu Ala Glu Pro Tyr Phe Arg Phe Ile Ile Thr Lys Glu Tyr 
    370                 375                 380                 


Lys Asn Leu Gly Phe Ser Ile Lys Thr Leu Arg Glu Met Leu Leu Asp 
385                 390                 395                 400 


Gln Pro Asp Leu Gln Glu Ile Arg Glu Asn His Asn Val Tyr Asp Ser 
                405                 410                 415     


Ile Arg Ser Lys Leu Tyr Lys Met Met Asp Phe Val Leu Val Tyr Ala 
            420                 425                 430         


Tyr Ser Asn Glu Arg Lys Ser Lys Ala Asp Ala Leu Ala Ser Asn Leu 
        435                 440                 445             


Arg Ser Ala Ile Thr Glu Asp Ala Lys Lys Arg Ile Tyr Gln Asn Glu 
    450                 455                 460                 


Ala Asp Gln Leu Trp Thr Ser Tyr Gln Glu Leu Phe Lys Arg Ile Arg 
465                 470                 475                 480 


Gly Phe Lys Gly Ala Gln Val Lys Glu Tyr Ser Ser Gln Asn Ile Pro 
                485                 490                 495     


Ile Pro Ile Gln Lys Gln Ile Gln Asn Ile Leu Lys Pro Ala Glu Gln 
            500                 505                 510         


Val Thr Cys Phe Thr Lys Leu Met Tyr Leu Leu Thr Met Phe Leu Asp 
        515                 520                 525             


Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp 
    530                 535                 540                 


Asn Ile Ser Ser Leu Leu Lys Thr Met Glu Gln Leu Glu Leu Gln Thr 
545                 550                 555                 560 


Thr Phe Lys Glu Asp Tyr Thr Phe Phe Gln Gln Ser Ser Cys Leu Cys 
                565                 570                 575     


Glu Glu Ile Thr Gln Leu Lys Ser Phe Ala Arg Met Gly Asn Pro Ile 
            580                 585                 590         


Ser Asn Leu Lys Glu Val Met Met Val Asp Ala Ile Gln Ile Leu Gly 
        595                 600                 605             


Thr Glu Lys Ser Glu Gln Glu Leu Gln Ser Met Ala Cys Phe Phe Phe 
    610                 615                 620                 


Arg Asp Lys Asn Gly Lys Lys Leu Asn Ala Gly Glu His Gly Met Arg 
625                 630                 635                 640 


Asn Phe Ile Gly Asn Asn Val Ile Ser Asn Thr Arg Phe Gln Tyr Leu 
                645                 650                 655     


Ile Arg Tyr Gly Asn Pro Gln Lys Leu His Thr Leu Ser Gln Asn Glu 
            660                 665                 670         


Thr Val Val Arg Phe Val Leu Ser Arg Ile Ala Lys Asn Gln Arg Val 
        675                 680                 685             


Gln Gly Met Asn Gly Lys Asn Gln Ile Asp Arg Tyr Tyr Glu Thr Cys 
    690                 695                 700                 


Gly Gly Thr Asn Ser Trp Ser Val Ser Glu Glu Glu Lys Ile Asn Phe 
705                 710                 715                 720 


Leu Cys Lys Ile Leu Thr Asn Met Ser Tyr Asp Gln Phe Gln Asp Val 
                725                 730                 735     


Lys Gln Ser Asp Lys Ile Ile Thr Ala Glu Glu Lys Arg Lys Lys Glu 
            740                 745                 750         


Arg Tyr Lys Ala Ile Ile Ser Leu Tyr Leu Thr Val Leu Tyr Gln Leu 
        755                 760                 765             


Ile Lys Asn Leu Val Asn Ile Asn Ala Arg Tyr Ile Ile Ala Phe His 
    770                 775                 780                 


Cys Leu Glu Arg Asp Ala Ile Leu Tyr Ser Leu Lys Phe Asn Thr Ser 
785                 790                 795                 800 


Ile Asn Leu Lys Lys Arg Tyr Thr Ala Leu Thr Glu Met Ile Leu Gly 
                805                 810                 815     


Tyr Glu Thr Asp Glu Lys Ala Arg Arg Lys Asp Thr Arg Thr Ile Tyr 
            820                 825                 830         


Glu Lys Ala Glu Ala Ala Lys Asn Arg His Leu Lys Asn Val Lys Trp 
        835                 840                 845             


Asn Cys Lys Thr Arg Glu Asn Leu Glu Asn Ala Asp Lys Asn Ala Ile 
    850                 855                 860                 


Val Ala Phe Arg Asn Ile Val Ala His Leu Trp Ile Ile Arg Asp Ala 
865                 870                 875                 880 


Asp Arg Phe Ile Thr Glu Met Gly Ala Met Lys Arg Tyr Phe Asp Cys 
                885                 890                 895     


Tyr His Tyr Leu Leu Gln Arg Glu Leu Glu Tyr Ile Leu Glu Lys Ser 
            900                 905                 910         


Asn Gln Gly Ser Lys Tyr Thr Lys Lys Ser Leu Glu Lys Val Gln Gln 
        915                 920                 925             


Tyr His Ser Tyr Cys Lys Asp Phe Leu His Met Leu Cys Leu Pro Phe 
    930                 935                 940                 


Ala Tyr Cys Ile Pro Arg Tyr Lys Asn Leu Ser Ile Ala Glu Leu Phe 
945                 950                 955                 960 


Asp Arg His Glu Leu Glu Ala Glu Pro Lys Glu Glu Ala Ser Pro Ala 
                965                 970                 975     


Asn Asn Ser Gln Phe Ile Thr Thr 
            980                 


<210>  2932
<211>  975
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2932

Met Met Gly Lys His Leu Asn Ala Lys Gln Arg Glu Leu Glu Lys Lys 
1               5                   10                  15      


Leu Lys Asn Gln Gln Lys Gly Met Met Tyr Asn Lys Ser Thr Asp Ala 
            20                  25                  30          


Val Ser Val Pro Thr Leu Gln Ala Ala Pro Lys Lys Ala Ala Glu Ala 
        35                  40                  45              


Ser Thr Leu Ile Thr Pro Gly Thr Leu Lys Thr Lys Ala Lys Ala Met 
    50                  55                  60                  


Gly Leu Lys Ser Thr Leu Val Phe Asp Asp Lys Ile Val Val Thr Ser 
65                  70                  75                  80  


Phe Leu Asn Ser Lys Thr Glu Glu Asn Glu Lys Cys Ala His Ile Glu 
                85                  90                  95      


Lys Ile Thr Asp Cys Asn Gly Gln Thr Ile Val Glu Arg Pro Arg Met 
            100                 105                 110         


Phe Asn Thr Ser Ile Asn Ala Gln Gln Val Asp Leu Ser Lys Asp Asn 
        115                 120                 125             


Asp Glu Thr Asn Tyr Pro Asn Pro Ala Phe Glu Asp Cys Gly Arg Asp 
    130                 135                 140                 


Tyr Ile Asn Ile Lys Ser Ala Leu Glu Lys Arg Val Phe Gly Lys Thr 
145                 150                 155                 160 


Tyr Asn Lys Asp Asn Leu His Val Gln Ile Ala Tyr Asn Ile Phe Asp 
                165                 170                 175     


Ile Lys Lys Ile Ile Gly Thr Tyr Ile Asn Asn Ile Thr Tyr Ile Phe 
            180                 185                 190         


Tyr Asn Leu Gly Arg Glu Glu Tyr Asn Ala Lys Lys Asp Ile Ile Gly 
        195                 200                 205             


Asn Gln Asp Ser Asp Tyr Ile Asn Lys Leu Leu Asn Asn Thr Ser Ala 
    210                 215                 220                 


Tyr Phe Thr Tyr Phe Asp Gly Val Phe Lys Gln Ile Thr Asp Arg Asp 
225                 230                 235                 240 


Ser Asn Lys Asp Arg Glu Val Lys Asn Ser Tyr Asn Ala Leu Val Leu 
                245                 250                 255     


Lys Val Leu Tyr Tyr Leu Arg Gln Phe Cys Met His Gly Asn Thr Tyr 
            260                 265                 270         


Thr Lys Arg Asn Glu Glu Ser Phe Leu Ser Asp Thr Ala Leu Tyr Asn 
        275                 280                 285             


Val Lys Asp Phe Phe Ala Lys Ala Asp Pro Gln Ile Asn Glu Leu Ile 
    290                 295                 300                 


Asp Ala Val Tyr Ala Asp Gly Ile Lys Thr Ile Asn Asn Asp Phe Met 
305                 310                 315                 320 


Ala His Ala Lys Asn Asn Met Tyr Ile Ile Cys Glu Val Tyr Lys Asn 
                325                 330                 335     


Glu Val Glu Asp Ser Leu Met Lys Glu Tyr Tyr Asp Phe Val Val Arg 
            340                 345                 350         


Lys Glu Gly Asn Asn Leu Gly Phe Asn Thr Arg Gln Leu Arg Glu Ile 
        355                 360                 365             


Leu Ile Asp Lys Tyr Val Gly Asn Leu Arg Asp Lys Lys Tyr Asp Thr 
    370                 375                 380                 


Phe Arg Asn Lys Leu Tyr Thr Val Leu Gly Phe Ile Leu Val Lys Glu 
385                 390                 395                 400 


Ile Lys Arg Asn Pro Lys Ile Gln Asp Ser Phe Ile Ala Lys Leu Arg 
                405                 410                 415     


Ala Asn Gln Ser Gly Asp Glu Gly Lys Leu Asn Ile Tyr Asn Glu Phe 
            420                 425                 430         


Ala Pro Lys Ile Trp Ser Val Val Ser Ser Lys Phe Asn Ser Ala Ile 
        435                 440                 445             


Lys Cys Phe Asp Glu Glu Ser Leu Ser Lys Phe Lys Gly Tyr Lys Asp 
    450                 455                 460                 


Ile Asp Glu Ser Leu Ile Ser Lys Tyr Gly Ile Thr Val Ser Asn Thr 
465                 470                 475                 480 


Asp Thr Leu Val Lys Ile Leu Tyr Phe Leu Cys Lys Phe Leu Asp Gly 
                485                 490                 495     


Lys Glu Ile Asn Glu Leu Cys Cys Ala Met Ile Asn Lys Phe Asp Asn 
            500                 505                 510         


Ile Asn Asp Leu Ile Lys Thr Ala Ala Gln Cys Gly Glu Asp Ile Glu 
        515                 520                 525             


Phe Val Lys Glu Tyr Lys Leu Phe Ile Asn Ser Lys Asp Leu Ser Asp 
    530                 535                 540                 


Gln Ile Arg Val Val Lys Ser Ile Ser Lys Met Lys Pro Glu Leu Ser 
545                 550                 555                 560 


Asn Ile Gly Glu Val Leu Leu Leu Asp Ala Ile Asp Ile Leu Gly Tyr 
                565                 570                 575     


Lys Ile Asn Lys Tyr Lys Cys Asp Ala Asp Gly Asn Arg Leu Val Asp 
            580                 585                 590         


Ser Asn Asn Lys Pro Val Tyr Ser Glu Glu Tyr Cys Thr Phe Lys Lys 
        595                 600                 605             


Asp Phe Phe Glu Thr Cys Glu Leu Asp Glu Phe Gly Arg Val Lys Tyr 
    610                 615                 620                 


Asp Lys Lys Gly Lys Pro Val Ile Asn His Arg Arg Arg Asn Phe Ile 
625                 630                 635                 640 


Ile Asn Asn Val Leu Ser Ser Lys Trp Phe Phe Tyr Val Ala Lys Tyr 
                645                 650                 655     


Asn Arg Pro Ser Glu Cys Gln Lys Phe Met Lys Ser Lys Lys Leu Ile 
            660                 665                 670         


Ala Leu Ala Leu Lys Asp Val Pro Glu Thr Gln Ile Ala Arg Tyr Tyr 
        675                 680                 685             


His Ser Val Thr Gly Gly Arg Glu Gln Thr Asp Ser Glu Ala Met Arg 
    690                 695                 700                 


Thr Thr Leu Ile Ser Arg Leu His Glu Phe Ser Ile Lys Asp Val Leu 
705                 710                 715                 720 


Ser Ser Val Gly Ser Met Thr Ala Ser Glu Asn Lys Arg Gln Ile Glu 
                725                 730                 735     


Asn Ser Arg Lys Glu Gln Met Lys Ala Ile Val Lys Leu Tyr Leu Thr 
            740                 745                 750         


Val Val Tyr Leu Ile Ala Lys Ser Leu Val Lys Val Asn Thr Arg Phe 
        755                 760                 765             


Ser Ile Ala Phe Ser Ala Tyr Glu Arg Asp Val Ser Leu Leu Ala Asp 
    770                 775                 780                 


Glu Asn Glu Ser Ile Ala Met Ala Asp Asn Asp Asp Asp Lys Trp Lys 
785                 790                 795                 800 


Thr Gly Asn Tyr Ile Phe Ala Leu Thr Lys His Phe Leu Asp Asn Asp 
                805                 810                 815     


Glu Pro Tyr Phe Asp Lys Tyr Asn Asn Ala Leu Gln Gln Ile Lys Gly 
            820                 825                 830         


Ile Thr Asp Pro Asn Glu Arg Arg Leu Ala Tyr Arg Ala Asn Asp Lys 
        835                 840                 845             


Val Ile Lys His Thr His Phe Asn Leu His Thr Asn Lys Tyr Val Lys 
    850                 855                 860                 


Asp Asn Tyr Glu Lys Ile Ser Lys Met Asn Lys Ile Val Thr Glu Tyr 
865                 870                 875                 880 


Arg Asn Asn Val Gln His Leu Ala Val Val Asn Asn Ile Thr Lys Tyr 
                885                 890                 895     


Leu Gly Asp Ile Ser Glu Val Thr Ser Tyr Tyr Ser Leu Tyr Cys Tyr 
            900                 905                 910         


Ile Leu Gln Arg Leu Leu Leu Asp Asn Asn Asn Asn Asp Lys Phe Ala 
        915                 920                 925             


Glu Ile Lys Glu Lys Leu Ile Lys Phe Gly Thr Tyr Asn Lys Asp Phe 
    930                 935                 940                 


Met Trp Leu Ile Asn Val Pro Phe Ala Tyr Asn Leu Pro Arg Tyr Lys 
945                 950                 955                 960 


Asn Leu Ser Asn Glu Glu Ile Phe Tyr Asp Val Ile Gln Asn Lys 
                965                 970                 975 


<210>  2933
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2933

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asn Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Asp Glu Ser His Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe Thr Asp 
    210                 215                 220                 


Pro Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Asn Ala Leu Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Ile Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Leu Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ser Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Met Gly Ala Lys Arg Arg 
        675                 680                 685             


Glu Leu Ala Lys Met Ile Lys Ser Ile Ser Phe Glu Asp Phe Lys Asp 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Asn Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Asn Lys Tyr Ile Lys Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Asn Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2934
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2934

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asp Asn Asp Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Gln Asn Thr Tyr Tyr Ile 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val 
            260                 265                 270         


Ser Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu 
    290                 295                 300                 


Tyr Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Val Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2935
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2935

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Phe Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Asn Arg Val Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Ile Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Leu Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Lys Val Ala Glu Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp Asp Lys 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Phe Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  2936
<211>  957
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2936

Met Ile Leu Ile Leu Gly Glu Gly Thr Ile Arg Met Ala Lys Lys Lys 
1               5                   10                  15      


Asn Ala Arg Gln Arg Arg Glu Glu Glu Lys Asn Arg Ile Lys Ala Ile 
            20                  25                  30          


Ile Glu Lys Ile Lys Asn Lys Val Val Glu Lys Glu Glu Thr Glu Glu 
        35                  40                  45              


Ile Val Glu Asn Asn Glu Thr Lys Asn Val Glu Ser Ile Val Val Glu 
    50                  55                  60                  


Pro Lys Lys Lys Ser Leu Ala Lys Ala Ser Gly Val Lys Ser Val Phe 
65                  70                  75                  80  


Ile Asn Asn Asp Glu Ile Ile Met Thr Ser Phe Gly Arg Gly Asn Asp 
                85                  90                  95      


Ala Val Ile Glu Lys Ile Ile Lys Asp Asn Asn Ile Asp Asn Glu Asn 
            100                 105                 110         


Lys Asp Lys Pro Val Tyr Asp Val Val Ala Ile Glu Asn Glu Gly Asn 
        115                 120                 125             


Ile Ile Lys Val Gln Ser Glu Arg Phe Lys Ala Ile Glu Ser Ala Asn 
    130                 135                 140                 


Thr Glu Ile Pro Pro Glu Arg Asn Gly Met Asp Leu Ile Lys Arg Lys 
145                 150                 155                 160 


Asp Lys Leu Glu Glu Val Tyr Phe Gly His Thr Phe Asn Asp Asn Ile 
                165                 170                 175     


His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ser 
            180                 185                 190         


Val Tyr Ile Asn Asn Ile Val Tyr Ala Leu Gly Asn Leu Glu Arg Lys 
        195                 200                 205             


Asp Thr Asp Glu Glu Lys Asp Leu Ile Gly Tyr Ser Ser Ala Arg Ala 
    210                 215                 220                 


Lys Tyr Glu Asp Phe Ile Glu Asn Glu Lys Leu Glu Asp Arg Lys Lys 
225                 230                 235                 240 


Leu Leu Glu Glu Phe Ile Glu Asn Gly Asp Arg Leu Gly Tyr Phe Gly 
                245                 250                 255     


Asn Val Phe Phe Lys Asn Asp Lys Glu Leu Lys Ser Lys Lys Glu Ile 
            260                 265                 270         


Tyr Asn Ile Leu Gly Leu Leu Gly Ser Leu Arg Gln Phe Cys Phe His 
        275                 280                 285             


Tyr Asn Glu Ala Val Phe Glu Asn Glu Glu Gly Lys Ile Asn Gln Glu 
    290                 295                 300                 


Tyr Lys Ser Asn Ser Trp Leu Tyr Asn Leu Gly Gln Leu Phe Asp Glu 
305                 310                 315                 320 


Phe Lys Asp Thr Leu Asn Gly Phe Tyr Asn Glu Lys Ile Asp Ser Ile 
                325                 330                 335     


Asn Lys Asp Phe Ile Lys Thr Asn Gln Ile Asn Leu His Ile Ile Cys 
            340                 345                 350         


Ser Glu Leu Gly Met Asn Met Asp Lys Glu Gln Val Val Gly Asp Tyr 
        355                 360                 365             


Tyr Asp Phe Ile Ile Ser Lys Lys His Lys Asn Met Gly Phe Ser Ile 
    370                 375                 380                 


Lys Lys Ile Arg Glu Tyr Met Phe Asp Ile Tyr Glu Ala Phe Asp Ile 
385                 390                 395                 400 


Lys Asp Lys Glu Phe Asp Ser Val Arg Ser Ile Leu Tyr Lys Ile Ile 
                405                 410                 415     


Asp Phe Ile Ile Tyr Tyr Ser Phe Ile His Tyr Lys Asn Asp Ile Ala 
            420                 425                 430         


Glu Asn Ile Val Ser Arg Leu Arg Val Ser Leu Ser Glu Glu Asp Lys 
        435                 440                 445             


Asp Lys Val Tyr Glu Glu Ile Ala Arg Asp Thr Trp Asn Glu Tyr Lys 
    450                 455                 460                 


Asp Gln Ile Asn Lys Leu Lys Glu Leu Leu Thr Lys Arg Ile Gly Glu 
465                 470                 475                 480 


Phe Ser Asp Ala Lys Asn Lys Asn Val Tyr Tyr Lys Glu Phe Glu Ser 
                485                 490                 495     


Ile Lys Phe Asp Glu Ile Gly Lys Lys Lys Leu Gly Glu Asn Ala Asp 
            500                 505                 510         


Tyr Phe Cys Lys Leu Met Tyr Leu Leu Thr Leu Phe Leu Asp Gly Lys 
        515                 520                 525             


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp Asn Ile 
    530                 535                 540                 


Arg Ser Phe Ile Glu Ile Met Glu Glu Lys Gln Ile Glu Cys Asn Phe 
545                 550                 555                 560 


Asp Glu Lys Phe Ser Phe Phe Asp Glu Ser Lys Asn Val Cys Asp Thr 
                565                 570                 575     


Leu Arg Glu Val Asn Ser Phe Ala Arg Met Gln Arg Pro Leu Asp Asn 
            580                 585                 590         


Lys Ser Val Gln Arg Glu Met Tyr Arg Asp Ala Ile Lys Ile Leu Leu 
        595                 600                 605             


Lys Asp Thr Trp Val Glu Glu Lys Asn Ile Asp Arg Ile Leu Asp Glu 
    610                 615                 620                 


Tyr Ile Pro Asn Lys Glu Asn Lys Ser Ile Lys Lys Asp Phe Arg Asn 
625                 630                 635                 640 


Phe Ile Ile Lys Asn Ile Ile Lys Ser Asn Arg Phe Ile Tyr Leu Ile 
                645                 650                 655     


Lys Tyr Ser Asn Pro Thr Asp Val Arg Lys Leu Ala Ser Asn Lys Asp 
            660                 665                 670         


Val Val Lys Phe Val Leu Asn Thr Ile Pro Glu Ala Gln Ile Asp Arg 
        675                 680                 685             


Tyr Tyr Asn Ser Cys Gly Leu Pro Leu Glu Glu Asp Asn Asn Val Gln 
    690                 695                 700                 


Ile Glu Lys Leu Ser Asp Ile Ile Thr Asn Ile Asp Tyr Ile Glu Phe 
705                 710                 715                 720 


Leu Asp Val Gln Gln Ser Tyr Lys Asn Glu Asp Lys Ser Lys Lys Gln 
                725                 730                 735     


Ala Val Val Thr Leu Tyr Leu Thr Ile Leu Tyr Ile Leu Thr Lys Asn 
            740                 745                 750         


Leu Val Asn Val Asn Ser Arg Tyr Val Ile Ala Leu His Cys Leu Glu 
        755                 760                 765             


Arg Asp Ser Thr Leu Tyr Gly Ile Lys Leu Lys Lys Glu Lys Asn Lys 
    770                 775                 780                 


Pro Ser Lys Tyr His Lys Leu Thr Gln Tyr Phe Ile Asp Asn Arg Tyr 
785                 790                 795                 800 


Phe Asp Arg Lys Lys Lys Asp Arg Lys Asn Gly Glu Tyr Val Ser Lys 
                805                 810                 815     


Lys Ile Ser Gly Tyr Ile Glu Lys Asn Met Lys Asn Tyr Ile Glu Cys 
            820                 825                 830         


Glu Gln Ile Glu Thr Thr Glu Gln Tyr Lys Glu Thr Gly Val Asp Met 
        835                 840                 845             


Phe Ile Asn Tyr Arg Asn Ser Ile Ala His Leu Asn Thr Val Arg Lys 
    850                 855                 860                 


Ala Ser Lys Tyr Ile Lys Asp Ile Lys Tyr Phe Gly Thr Tyr Phe Glu 
865                 870                 875                 880 


Leu Tyr His Tyr Ile Met Gln Arg Tyr Leu Lys Asp Asn Ile Glu Leu 
                885                 890                 895     


Lys Gly Glu Asn Asn Ala Leu Glu Gly Tyr Phe Asp Asn Leu Cys Lys 
            900                 905                 910         


Tyr Gly Thr Tyr Val Lys Asp Phe Val Lys Thr Leu Asn Val Pro Phe 
        915                 920                 925             


Ala Tyr Asn Tyr Pro Arg Tyr Lys Asn Leu Ser Ile Asp Glu Leu Phe 
    930                 935                 940                 


Asp Lys Asn Asn Thr Arg Lys Thr Lys Lys Ser Ser Leu 
945                 950                 955         


<210>  2937
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2937

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Ile Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Pro Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn His Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr His Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2938
<211>  975
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2938

Met Gly Lys Lys Ile His Ala Arg Asp Leu Arg Glu Gln Arg Lys Thr 
1               5                   10                  15      


Asp Arg Thr Val Lys Phe Ala Asp Gln Asn Lys Lys Arg Glu Ala Glu 
            20                  25                  30          


Arg Ala Val Gln Lys Lys Asp Ala Ala Val Ser Val Lys Ser Val Ser 
        35                  40                  45              


Ser Val Ser Ser Lys Lys Asp Asn Ala Thr Lys Ser Met Ala Lys Ala 
    50                  55                  60                  


Ala Gly Val Lys Ser Val Phe Ala Val Gly Asn Thr Val Tyr Met Thr 
65                  70                  75                  80  


Ser Phe Gly Arg Gly Asn Asp Ala Val Leu Glu Gln Lys Ile Val Asp 
                85                  90                  95      


Thr Ser His Glu Pro Leu Asn Ile Asp Asp Pro Ala Tyr Gln Leu Asn 
            100                 105                 110         


Val Val Thr Met Asn Gly Tyr Ser Val Thr Gly His Arg Gly Glu Thr 
        115                 120                 125             


Val Ser Ala Val Thr Asp Asn Pro Leu Arg Arg Phe Asn Gly Gly Lys 
    130                 135                 140                 


Lys Gly Glu Pro Glu Gln Ser Val Pro Thr Asp Met Leu Cys Leu Lys 
145                 150                 155                 160 


Pro Thr Leu Glu Lys Lys Phe Phe Gly Lys Glu Phe Asn Asp Asn Ile 
                165                 170                 175     


His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala 
            180                 185                 190         


Val Tyr Ser Thr Asn Ala Ile Tyr Ala Leu Asn Asn Met Ser Ala Asp 
        195                 200                 205             


Glu Asn Ile Glu Asn Ser Asp Phe Phe Met Lys Arg Thr Thr Asp Glu 
    210                 215                 220                 


Thr Phe Asp Asp Phe Glu Lys Lys Lys Glu Ser Thr Asn Ser Arg Glu 
225                 230                 235                 240 


Lys Ala Asp Phe Asp Ala Phe Glu Lys Phe Ile Ala Asn Tyr Arg Leu 
                245                 250                 255     


Ala Tyr Phe Ala Asp Ala Phe Tyr Val Asn Lys Lys Asn Pro Lys Gly 
            260                 265                 270         


Lys Ala Lys Asn Val Leu Arg Glu Asp Lys Glu Leu Tyr Ser Val Leu 
        275                 280                 285             


Thr Leu Ile Gly Lys Leu Arg His Trp Cys Val His Ser Glu Asp Gly 
    290                 295                 300                 


Arg Ala Glu Phe Trp Leu Tyr Lys Leu Asp Glu Leu Lys Asp Asp Phe 
305                 310                 315                 320 


Lys Asn Val Leu Asp Val Val Tyr Asn Arg Pro Val Glu Glu Ile Asn 
                325                 330                 335     


Asn Arg Phe Ile Glu Asn Asn Lys Val Asn Ile Gln Ile Leu Gly Ser 
            340                 345                 350         


Val His Glu Asp Thr Asp Ile Ala Glu Leu Thr Arg Ser Tyr Tyr Glu 
        355                 360                 365             


Phe Leu Ile Thr Lys Lys Tyr Lys Asn Met Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Ile Ile Leu Glu Gly Thr Glu Tyr Asn Asp Asn Lys Tyr 
385                 390                 395                 400 


Asp Thr Val Arg Asn Lys Leu Tyr Gln Ile Val Asp Phe Ile Leu Tyr 
                405                 410                 415     


Arg Gly Tyr Ile Asn Glu Asn Ser Glu Arg Ala Glu Val Leu Val Asn 
            420                 425                 430         


Ala Leu Arg Ser Thr Leu Asn Glu Asp Asp Lys Thr Lys Leu Tyr Ser 
        435                 440                 445             


Ser Glu Ala Ala Phe Leu Lys Lys Lys Tyr Met Lys Ile Ile Arg Lys 
    450                 455                 460                 


Ala Ala Asp Ser Leu Asp Val Lys Lys Leu Lys Asp Leu Lys Lys Lys 
465                 470                 475                 480 


Ala Phe Thr Ile Pro Asp Asn Glu Leu Arg Lys Cys Phe Ile Ser Tyr 
                485                 490                 495     


Ala Asp Ser Val Ser Glu Phe Thr Lys Leu Ile Tyr Leu Leu Thr Arg 
            500                 505                 510         


Phe Leu Ser Gly Lys Glu Ile Asn Asp Leu Val Thr Thr Leu Ile Asn 
        515                 520                 525             


Lys Phe Asp Asn Ile Arg Ser Phe Leu Glu Ile Met Asp Glu Leu Gly 
    530                 535                 540                 


Leu Glu Arg Thr Phe Thr Asp Glu Tyr Arg Phe Phe Glu Gly Ser Thr 
545                 550                 555                 560 


Lys Tyr Leu Ala Glu Leu Val Glu Leu Asn Ser Phe Val Lys Ser Cys 
                565                 570                 575     


Ser Phe Asp Met Ser Ala Lys Arg Thr Met Tyr Arg Asp Ala Leu Asp 
            580                 585                 590         


Ile Leu Gly Ile Glu Ser Asp Lys Thr Glu Glu Asp Ile Glu Lys Met 
        595                 600                 605             


Ile Asp Asn Ile Leu Gln Val Asp Ala Asn Gly Lys Lys Leu Pro Asn 
    610                 615                 620                 


Lys Asn His Gly Leu Arg Asn Phe Ile Ala Ser Asn Val Ile Asp Ser 
625                 630                 635                 640 


Asn Arg Phe Glu Tyr Leu Val Arg Tyr Gly Asn Pro Lys Lys Ile Arg 
                645                 650                 655     


Glu Thr Ala Lys Cys Glu Pro Ala Val Arg Phe Val Leu Asn Glu Ile 
            660                 665                 670         


Pro Asp Ala Gln Ile Glu Arg Tyr Tyr Lys Ala Tyr Tyr Pro Asp Glu 
        675                 680                 685             


Lys Ser Leu Cys Leu Ala Asn Met Gln Arg Asp Lys Leu Ala Gly Val 
    690                 695                 700                 


Ile Ala Asp Ile Lys Phe Asp Asp Phe Ser Asp Ala Gly Ser Tyr Gln 
705                 710                 715                 720 


Lys Ala Asn Ala Thr Ser Thr Arg Arg Thr Ser Glu Ala Glu Ile Lys 
                725                 730                 735     


Arg Lys Asn Gln Ala Ile Ile Arg Leu Tyr Leu Thr Val Met Tyr Ile 
            740                 745                 750         


Met Leu Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Phe 
        755                 760                 765             


His Cys Leu Glu Arg Asp Ala Lys Leu Tyr Ser Glu Ser Val Leu Lys 
    770                 775                 780                 


Val Gly Asn Thr Asn Glu Glu Ser Arg Leu Gln Thr Gly Asn Thr Asn 
785                 790                 795                 800 


Glu Glu Lys Asn Lys Val Lys Leu Thr Asn Leu Thr Asn Leu Thr Met 
                805                 810                 815     


Ala Val Met Gly Val Lys Leu Glu Asn Gly Thr Ile Lys Thr Glu Phe 
            820                 825                 830         


Asp Lys Ser Leu Ala Glu Asn Ala Ala Asn Arg Tyr Leu Arg Asn Ala 
        835                 840                 845             


Arg Trp Tyr Lys Leu Ile Leu Asp Asn Leu Lys Lys Ser Glu Arg Ala 
    850                 855                 860                 


Val Val Thr Glu Phe Arg Asn Thr Val Cys His Leu Asn Ala Ile Arg 
865                 870                 875                 880 


Asn Ile Asn Ile Asn Ile Lys Glu Val Lys Glu Val Glu Asn Tyr Phe 
                885                 890                 895     


Ala Leu Tyr His Tyr Leu Ile Gln Lys His Leu Glu Lys Arg Phe Ala 
            900                 905                 910         


Asp Lys Lys Val Glu Arg Asp Thr Gly Asp Phe Ile Ser Lys Leu Glu 
        915                 920                 925             


Glu His Lys Thr Tyr Cys Lys Asp Phe Val Lys Ala Tyr Cys Thr Pro 
    930                 935                 940                 


Phe Gly Tyr Asn Leu Val Arg Tyr Lys Asn Leu Thr Ile Asp Gly Leu 
945                 950                 955                 960 


Phe Asp Lys Asn Tyr Pro Gly Lys Asp Asp Ser Asp Gln Gln Lys 
                965                 970                 975 


<210>  2939
<211>  900
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2939

Leu Ser Thr Lys Lys Arg Phe Arg Tyr Ser Val Ala Ala Lys Ala Ala 
1               5                   10                  15      


Gly Leu Lys Ser Ser Leu Ala Val Asp Thr Asp Arg Thr Val Met Thr 
            20                  25                  30          


Ser Phe Gly His Gly Asn Ala Ala Ile Leu Glu Lys Glu Ile Val Asp 
        35                  40                  45              


Gly Glu Ile Ser Val Leu Asn Ile Glu Asn Pro Ala Phe Asp Ala Val 
    50                  55                  60                  


Ile Asn Asp Lys Lys Tyr Ala Leu Thr Gly His His Ala Gly Val His 
65                  70                  75                  80  


Ala Leu Val Asp Gln Pro Gln Asn Arg Ser Asp Ala Val His Ile Arg 
                85                  90                  95      


Gly Ala Leu Glu Lys Lys Tyr Phe Gly Asp Thr Phe Ala Asp Asn Ile 
            100                 105                 110         


His Val Gln Ile Ala Tyr Asn Ile Leu Asp Ile Thr Lys Ile Leu Thr 
        115                 120                 125             


Val Tyr Ala Asn Asn Val Val Tyr Ala Leu Asn Asn Leu Val His Ala 
    130                 135                 140                 


Asp Asp Asp Thr Gln Ala Asp Glu Leu Asp Ser Leu Gly Asn Phe Ser 
145                 150                 155                 160 


Ala Gly Thr Ser Tyr Ala Lys Ser Lys Ser Lys Ser Lys Ser Lys Gln 
                165                 170                 175     


Gln Asp Phe Val Glu Leu Phe Ile Lys Lys Lys Glu Ile His Gly Tyr 
            180                 185                 190         


Phe Gly Asp Thr Phe Ala Phe Leu Asp Lys Arg Ile Ala Asp Ala Asp 
        195                 200                 205             


Lys Glu Lys Gln Val Tyr Ala Met Leu Ala Cys Leu Gly Ser Leu Arg 
    210                 215                 220                 


Gln Ala Cys Ser His Tyr Arg Ile Arg Tyr Ser Val Asn Gly Lys Asn 
225                 230                 235                 240 


Val Asp Ala Asp Ala Asp Thr Trp Leu Phe Ser Ser Ala Gln Leu Asp 
                245                 250                 255     


Gln Thr Asp Pro Leu Phe Ser Glu Met Leu Asn Arg Ile Tyr Ser His 
            260                 265                 270         


Lys Ile Lys Thr Val Asn Gln Asn Phe Phe Glu Asn Asn Arg Lys Ala 
        275                 280                 285             


Asn Phe Pro Ile Leu Lys Lys Met Tyr Pro Glu Thr Thr Leu Lys Val 
    290                 295                 300                 


Leu Met Asn Glu Tyr Tyr Asp Phe Ser Ile Arg Lys Gly Tyr Lys Asn 
305                 310                 315                 320 


Phe Gly Phe Ser Ile Lys Ser Leu Arg Glu Ala Leu Leu Ser Pro Gln 
                325                 330                 335     


Tyr Glu Ser Leu Ile Gly Val Gln Ile Lys Asp Asn Lys Glu Tyr Asp 
            340                 345                 350         


Thr Val Arg Ser Lys Leu Tyr Gln Leu Phe Asp Phe Ala Leu Thr Arg 
        355                 360                 365             


Tyr Phe Asn Gln His Pro Asp Met Val Asp Ala Phe Val Val Glu Leu 
    370                 375                 380                 


Arg Ser Leu Ala Lys Asp Glu Asp Ala Lys Asn Ala Val Tyr Glu Lys 
385                 390                 395                 400 


Tyr Ala Lys Ala Val Trp Asn Asp Val Lys Gln Pro Ile Ala Val Met 
                405                 410                 415     


Leu Ser Tyr Met Asn Gly Ser Ala Ile Lys Asn Ile Lys Ala Phe Glu 
            420                 425                 430         


Leu Lys Pro Asp Gln Lys Glu Leu Asn Gly Ile Met Asn Ser Asn Ala 
        435                 440                 445             


Leu Asp Val Pro His Phe Cys Lys Leu Val Tyr Phe Leu Thr Arg Phe 
    450                 455                 460                 


Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Val Asn Lys 
465                 470                 475                 480 


Phe Asp Asn Ile His Ser Phe Asn Gln Val Leu Thr Ala Leu Gly Leu 
                485                 490                 495     


Ser Ala Ser Tyr Glu Ala Asp Tyr Lys Ile Phe Glu Asp Ser Gly Arg 
            500                 505                 510         


Val Val Glu Tyr Leu Arg Glu Ile Asn Ser Phe Ala Arg Met Thr Val 
        515                 520                 525             


Asp Met Glu Lys Ile Lys Arg Ser Ala Tyr Lys Lys Ala Leu Leu Ile 
    530                 535                 540                 


Leu Gly Ser Ser Lys Tyr Ser Asp Glu Asp Leu Asp Ala Arg Val Asp 
545                 550                 555                 560 


Glu Met Leu Gly Val Asp Tyr Asn Gln Asn Gly Glu Lys Ile Lys Val 
                565                 570                 575     


Arg Val Asp Thr Gly Phe Arg Asn Phe Ile Ala Asn Asn Val Val Glu 
            580                 585                 590         


Ser Ser Arg Phe His Tyr Leu Ile Arg Tyr Cys His Pro Arg Lys Ile 
        595                 600                 605             


Arg Asn Leu Ala Gly Asn Ala Ala Leu Ile Glu Tyr Gln Leu Arg Arg 
    610                 615                 620                 


Leu Pro Glu Leu Gln Ile Leu Arg Tyr Tyr Glu Ala Cys Thr Glu Pro 
625                 630                 635                 640 


Ile Lys Arg Thr Ala Arg Thr Met Asp Glu Lys Ile Gly Thr Leu Ile 
                645                 650                 655     


Asp Leu Ile Val Lys Met Asp Phe Ser Gln Phe Glu Asp Val Gln Gln 
            660                 665                 670         


Asn Asp Arg Val Arg Val Phe Ser Asp Ala Glu Lys Lys Glu Lys Ile 
        675                 680                 685             


Arg Lys Met Arg Glu Lys Gln Arg Tyr Gln Ser Ile Ile Ser Leu Tyr 
    690                 695                 700                 


Leu Thr Met Leu Tyr Leu Ile Val Lys Asn Leu Val Asn Ile Asn Ala 
705                 710                 715                 720 


Arg Tyr Val Met Ala Phe Gln Ala Trp Glu Arg Asp Asn Tyr Leu Leu 
                725                 730                 735     


Leu Gln Leu Ser Gly Lys Glu Ala Glu Ala Glu Tyr Leu Asn Leu Thr 
            740                 745                 750         


Arg His Phe Ile Glu Pro Leu Asp Gly Ala Lys Pro Tyr Leu Lys Lys 
        755                 760                 765             


Arg Pro Val Glu Tyr Leu Lys Lys Asp Met Ala Met Val Gly Asn Ser 
    770                 775                 780                 


Ser Ile Arg His Phe Arg Asn Ala Thr Val His Leu Asn Val Ile Met 
785                 790                 795                 800 


Glu Ala His Arg Tyr Thr Lys Asp Ile Lys Tyr Ile Gly Ser Tyr Tyr 
                805                 810                 815     


Ala Leu Tyr His Tyr Ile Leu Gln Arg His Leu Leu Asp Lys Ile Glu 
            820                 825                 830         


Glu Asp Ser Tyr Ala Glu Lys Thr Val Ser Glu Lys Leu Trp Glu Ser 
        835                 840                 845             


Gln Ile Ser Gln Tyr Gly Thr Tyr Ser Lys Asp Phe Val Lys Ala Leu 
    850                 855                 860                 


Cys Cys Pro Phe Gly Tyr Asn Leu Pro Arg Phe Lys Asn Leu Ser Ile 
865                 870                 875                 880 


Glu Gln Leu Phe Asp Arg Asn Glu Ser Lys Glu Ile Thr Asp Ala Thr 
                885                 890                 895     


Ala Pro Arg Gln 
            900 


<210>  2940
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2940

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Asp Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Lys 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Leu Glu Asn Glu Ser Asn Asn Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe Thr Asp Pro 
    210                 215                 220                 


Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn Ile Lys Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu Tyr Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Ile Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Asp Asp Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Ile Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Val Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Arg Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  2941
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2941

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Ser Ser Asn Ile Glu Leu Arg Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Lys Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe Thr Asn 
    210                 215                 220                 


Pro Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Lys Asn Ile Arg Lys 
225                 230                 235                 240 


Ser Leu Arg Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu His Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Ile Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Lys Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Arg Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  2942
<211>  954
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2942

Met Gly Lys Lys Ile His Ala Arg Asp Leu Arg Glu Gln Arg Lys Thr 
1               5                   10                  15      


Asp Arg Thr Val Lys Phe Ala Asp Gln Asn Lys Lys Arg Glu Ala Gln 
            20                  25                  30          


Arg Ala Val Gln Lys Lys Asp Ala Ala Val Ser Val Lys Ser Val Ser 
        35                  40                  45              


Ser Val Ser Ser Lys Lys Asp Asn Val Thr Lys Ser Met Ala Lys Ala 
    50                  55                  60                  


Ala Gly Val Lys Ser Val Phe Ala Val Gly Asn Thr Val Tyr Met Thr 
65                  70                  75                  80  


Ser Phe Gly Arg Gly Asn Asp Ala Val Leu Glu Gln Lys Ile Val Asp 
                85                  90                  95      


Thr Ser His Glu Pro Leu Asn Ile Asp Asp Pro Ala Tyr Gln Leu Asn 
            100                 105                 110         


Val Val Thr Met Asn Gly Tyr Ser Val Thr Gly His Arg Gly Glu Thr 
        115                 120                 125             


Val Ser Ala Val Thr Asp Asn Pro Leu Arg Arg Phe Asn Gly Gly Lys 
    130                 135                 140                 


Lys Asp Glu Pro Glu Gln Ser Val Pro Thr Asp Met Leu Cys Leu Lys 
145                 150                 155                 160 


Pro Thr Leu Glu Lys Lys Phe Phe Gly Lys Glu Phe Asn Asp Asn Ile 
                165                 170                 175     


His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala 
            180                 185                 190         


Val Tyr Ser Thr Asn Ala Ile Tyr Ala Leu Asn Asn Met Ser Ala Asp 
        195                 200                 205             


Glu Asn Ile Glu Asn Ser Asp Phe Phe Met Lys Arg Thr Thr Asp Glu 
    210                 215                 220                 


Thr Phe Asp Asp Phe Glu Lys Lys Lys Glu Ser Thr Asn Ser Arg Glu 
225                 230                 235                 240 


Lys Ala Asp Phe Asp Ala Phe Glu Lys Phe Ile Gly Asn Tyr Arg Leu 
                245                 250                 255     


Ala Tyr Phe Ala Asp Ala Phe Tyr Val Asn Lys Lys Asn Pro Lys Gly 
            260                 265                 270         


Lys Ala Lys Asn Val Leu Arg Glu Asp Lys Glu Leu Tyr Ser Val Leu 
        275                 280                 285             


Thr Leu Ile Gly Lys Leu Arg His Trp Cys Val His Ser Glu Glu Gly 
    290                 295                 300                 


Arg Ala Glu Phe Trp Leu Tyr Lys Leu Asn Glu Leu Lys Asp Asp Phe 
305                 310                 315                 320 


Lys Asn Val Leu Asp Val Val Tyr Asn Arg Pro Val Glu Glu Ile Asn 
                325                 330                 335     


Asn Arg Phe Ile Glu Asn Asn Lys Val Asn Ile Gln Ile Leu Gly Ser 
            340                 345                 350         


Val Tyr Lys Asn Thr Asp Ile Ala Glu Leu Val Arg Ser Tyr Tyr Glu 
        355                 360                 365             


Phe Leu Ile Thr Lys Lys Tyr Lys Asn Met Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Ser Met Leu Glu Gly Lys Gly Tyr Ala Asp Lys Glu Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Asn Lys Leu Tyr Gln Met Thr Asp Phe Ile Leu Tyr 
                405                 410                 415     


Thr Gly Tyr Ile Asn Glu Asp Ser Asp Arg Ala Asp Asp Leu Val Asn 
            420                 425                 430         


Thr Leu Arg Ser Ser Leu Lys Glu Asp Asp Lys Thr Thr Val Tyr Cys 
        435                 440                 445             


Lys Glu Ala Asp Tyr Leu Trp Lys Lys Tyr Arg Glu Ser Ile Arg Glu 
    450                 455                 460                 


Val Ala Asp Ala Leu Asp Val Asp Asn Ile Lys Asn Leu Ser Gly Ser 
465                 470                 475                 480 


Asn Ile Glu Ile Arg Asp Asn Glu Leu Arg Lys Cys Phe Ile Ser Tyr 
                485                 490                 495     


Ala Asp Ser Val Ser Glu Phe Thr Lys Leu Ile Tyr Leu Leu Thr Arg 
            500                 505                 510         


Phe Leu Ser Gly Lys Glu Ile Asn Asp Leu Val Thr Thr Leu Ile Asn 
        515                 520                 525             


Lys Phe Asp Asn Ile Arg Ser Phe Leu Glu Ile Leu Asp Glu Leu Gly 
    530                 535                 540                 


Leu Asp Arg Thr Phe Thr Ala Glu Tyr Ser Phe Phe Glu Gly Ser Thr 
545                 550                 555                 560 


Lys Tyr Leu Ala Glu Leu Val Glu Leu Asn Ser Phe Val Lys Ser Cys 
                565                 570                 575     


Ser Phe Asp Ile Asn Ala Lys Arg Thr Met Tyr Arg Asp Ala Leu Asp 
            580                 585                 590         


Ile Leu Gly Ile Lys Ser Gly Lys Thr Glu Glu Asp Ile Glu Lys Met 
        595                 600                 605             


Ile Asp Asn Ile Leu Gln Ile Asp Ala Asn Gly Asp Lys Lys Leu Lys 
    610                 615                 620                 


Lys Asn Asn Gly Leu Arg Asn Phe Ile Ala Ser Asn Val Ile Asp Ser 
625                 630                 635                 640 


Asn Arg Phe Lys Tyr Leu Val Arg Tyr Gly Asn Pro Lys Lys Ile Arg 
                645                 650                 655     


Glu Thr Ala Lys Cys Lys Pro Ala Val Arg Phe Val Leu Asn Glu Ile 
            660                 665                 670         


Pro Asp Ala Gln Ile Glu Arg Tyr Tyr Glu Ala Cys Cys Pro Lys Asn 
        675                 680                 685             


Thr Ala Leu Cys Ser Ala Asn Lys Arg Arg Glu Lys Leu Ala Asp Met 
    690                 695                 700                 


Ile Ala Glu Ile Lys Phe Glu Asn Phe Ser Asp Ala Gly Asn Tyr Gln 
705                 710                 715                 720 


Lys Ala Asn Val Thr Ser Arg Thr Ser Glu Ala Glu Ile Lys Arg Lys 
                725                 730                 735     


Asn Gln Ala Ile Ile Arg Leu Tyr Leu Thr Val Met Tyr Ile Met Leu 
            740                 745                 750         


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Phe His Cys 
        755                 760                 765             


Val Glu Arg Asp Thr Lys Leu Tyr Ala Glu Ser Gly Leu Glu Val Gly 
    770                 775                 780                 


Asn Ile Glu Lys Asn Lys Thr Asn Leu Thr Met Ala Val Met Gly Val 
785                 790                 795                 800 


Lys Leu Glu Asn Gly Ile Ile Lys Thr Glu Phe Asp Lys Ser Leu Ala 
                805                 810                 815     


Glu Asn Ala Ala Asn Arg Tyr Leu Arg Asn Ala Arg Trp Tyr Lys Leu 
            820                 825                 830         


Ile Leu Asp Asn Leu Lys Lys Ser Glu Arg Ala Val Val Asn Glu Phe 
        835                 840                 845             


Arg Asn Thr Val Cys His Leu Asn Ala Ile Arg Asn Ile Asn Ile Asn 
    850                 855                 860                 


Ile Asp Gly Ile Lys Glu Val Glu Asn Tyr Phe Ala Leu Tyr His Tyr 
865                 870                 875                 880 


Leu Ile Gln Lys His Leu Glu Asn Arg Phe Ala Asp Lys Lys Val Glu 
                885                 890                 895     


Arg Asp Thr Gly Asp Phe Ile Ser Lys Leu Glu Glu His Lys Thr Tyr 
            900                 905                 910         


Cys Lys Asp Phe Val Lys Ala Tyr Cys Thr Pro Phe Gly Tyr Asn Leu 
        915                 920                 925             


Val Arg Tyr Lys Asn Leu Thr Ile Asp Gly Leu Phe Asp Lys Asn Tyr 
    930                 935                 940                 


Pro Gly Lys Asp Asp Ser Asp Lys Gln Lys 
945                 950                 


<210>  2943
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2943

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Glu Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Lys Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asp Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Glu Asp Ser Ser Asn Ile Glu Leu Cys Gly 
            100                 105                 110         


Val Thr Lys Val Asn Ile Thr Phe Ser Ser Lys His Gly Leu Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Ser Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Phe Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Asn Arg Val 
            260                 265                 270         


Ser Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu His Glu 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Ile Ile Asp Pro Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Ile Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  2944
<211>  937
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2944

Met Ala Lys Lys Lys Arg Ile Thr Ala Lys Glu Arg Lys Gln Asn His 
1               5                   10                  15      


Arg Glu Ser Leu Met Lys Lys Ala Asp Ser Asn Ala Glu Lys Glu Lys 
            20                  25                  30          


Ala Lys Lys Pro Val Val Glu Asn Lys Pro Asp Thr Ala Ile Ser Lys 
        35                  40                  45              


Asp Asn Thr Pro Lys Pro Asn Lys Glu Ile Lys Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Ala Gly Val Lys Trp Val Ile Lys Ala Asn Asp Asp Val Ala Tyr 
65                  70                  75                  80  


Ile Ser Ser Phe Gly Lys Gly Asn Asn Ser Val Leu Glu Lys Arg Ile 
                85                  90                  95      


Met Gly Asp Val Ser Ser Asn Val Asn Lys Asp Ser His Met Tyr Val 
            100                 105                 110         


Asn Pro Lys Tyr Thr Lys Lys Asn Tyr Glu Ile Lys Asn Gly Phe Ser 
        115                 120                 125             


Ser Gly Ser Ser Leu Val Thr Tyr Pro Asn Lys Pro Asp Lys Asn Ser 
    130                 135                 140                 


Gly Met Asp Ala Leu Cys Leu Lys Pro Tyr Phe Glu Lys Asp Phe Phe 
145                 150                 155                 160 


Gly His Ile Phe Thr Asp Asn Met His Ile Gln Ala Ile Tyr Asn Ile 
                165                 170                 175     


Phe Asp Ile Glu Lys Ile Leu Ala Lys His Ile Thr Asn Ile Ile Tyr 
            180                 185                 190         


Thr Val Asn Ser Phe Asp Arg Asn Tyr Asn Gln Ser Gly Asn Asp Thr 
        195                 200                 205             


Ile Gly Phe Asp Ile Asn Tyr Arg Val Pro Tyr Ser Glu Tyr Gly Gly 
    210                 215                 220                 


Gly Lys Asp Ser Asn Gly Lys Pro Asn Lys Ile Ser Ala Trp Lys Lys 
225                 230                 235                 240 


Arg Glu Asn Phe Ile Lys Phe Tyr Asn Glu Ala Lys Pro His Leu Gly 
                245                 250                 255     


Tyr Tyr Glu Asn Ile Phe Tyr Glu His Gly Glu Pro Ile Ser Glu Glu 
            260                 265                 270         


Lys Phe Tyr Asn Tyr Leu Asn Ile Leu Asn Phe Ile Arg Asn Asn Thr 
        275                 280                 285             


Phe His Tyr Lys Asp Asn Asp Ile Glu Leu Tyr Gly Glu Asn Tyr Ser 
    290                 295                 300                 


Glu Glu Tyr Val Phe Ile Asn Cys Leu Asn Glu Phe Val Lys Asn Lys 
305                 310                 315                 320 


Phe Lys Asn Val Asn Lys Asn Phe Ile Ser Asn Glu Lys Asn Asn Leu 
                325                 330                 335     


Tyr Ile Ile Leu Lys Ala Tyr Gly Glu Asp Thr Glu Asn Val Glu Val 
            340                 345                 350         


Val Lys Lys Tyr Ser Lys Glu Leu Tyr Lys Leu Ser Val Leu Lys Thr 
        355                 360                 365             


Asn Lys Asn Leu Gly Val Asn Val Lys Lys Leu Arg Glu Ser Ala Ile 
    370                 375                 380                 


Glu Tyr Gly Tyr Cys Pro Leu Pro Tyr Asp Lys Glu Lys Glu Val Ala 
385                 390                 395                 400 


Lys Leu Ser Ser Val Lys His Lys Leu Tyr Lys Thr Tyr Asp Phe Val 
                405                 410                 415     


Ile Thr His Tyr Leu Asn Ser Asn Asp Lys Leu Leu Leu Glu Ile Val 
            420                 425                 430         


Glu Thr Leu Arg Leu Ser Lys Asn Asp Asp Glu Lys Glu Asn Val Tyr 
        435                 440                 445             


Lys Lys Tyr Ala Glu Lys Leu Phe Lys Ala Asp Asp Val Ile Asn Pro 
    450                 455                 460                 


Ile Lys Ala Ile Ser Lys Leu Phe Ala Glu Lys Gly Asn Lys Leu Phe 
465                 470                 475                 480 


Lys Glu Lys Ile Ile Ile Lys Lys Glu Tyr Ile Glu Asp Val Ser Ile 
                485                 490                 495     


Asp Lys Asn Ile Tyr Asp Phe Thr Lys Val Ile Phe Phe Met Thr Cys 
            500                 505                 510         


Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Asn Ile Ile Ser 
        515                 520                 525             


Lys Leu Gln Val Ile Glu Asp His Asn Asn Val Ile Lys Phe Ile Ser 
    530                 535                 540                 


His Asn Lys Asp Ala Val Tyr Lys Asp Tyr Ser Asp Lys Tyr Ala Ile 
545                 550                 555                 560 


Phe Arg Asn Ala Gly Lys Ile Ala Thr Glu Leu Glu Ala Ile Lys Ser 
                565                 570                 575     


Ile Ala Arg Met Glu Asn Lys Ile Glu Asn Ala Pro Gln Glu Pro Leu 
            580                 585                 590         


Leu Asn Asp Ala Leu Leu Ala Leu Gly Val Ser Lys Thr Asp Leu Glu 
        595                 600                 605             


Asn Thr Tyr Asn Lys Tyr Phe Asp Ser Lys Glu Lys Thr Asp Lys Gln 
    610                 615                 620                 


Ser Gln Lys Val Ser Thr Phe Leu Met Asn Asn Val Ile Asn Asn Asn 
625                 630                 635                 640 


Arg Phe Lys Tyr Val Ile Lys Tyr Ile Asn Pro Ala Asp Ile Asn Gly 
                645                 650                 655     


Leu Ala Lys Asn Arg Tyr Leu Val Lys Phe Val Leu Ser Lys Ile Pro 
            660                 665                 670         


Glu Glu Gln Ile Asp Ser Tyr Tyr Lys Leu Phe Ser Asn Glu Glu Glu 
        675                 680                 685             


Pro Ser Cys Glu Glu Lys Ile Lys Leu Leu Thr Lys Lys Ile Ser Lys 
    690                 695                 700                 


Leu Asn Phe Gln Thr Leu Phe Glu Asn Asn Lys Ile Pro Asn Val Glu 
705                 710                 715                 720 


Lys Glu Arg Lys Lys Ala Ile Ile Thr Leu Tyr Phe Thr Ile Val Tyr 
                725                 730                 735     


Ile Leu Val Lys Asn Leu Val Asn Ile Asn Gly Leu Tyr Thr Leu Ala 
            740                 745                 750         


Leu Tyr Phe Val Glu Arg Asp Arg Tyr Phe Tyr Lys Lys Ile Cys Gly 
        755                 760                 765             


Lys Ala Leu Arg Arg Lys Val Gly Asp Lys Tyr Asp Tyr Leu Leu Leu 
    770                 775                 780                 


Pro Glu Ile Phe Ser Gly Ser Lys Tyr Arg Glu Glu Thr Lys Asn Leu 
785                 790                 795                 800 


Lys Leu Pro Lys Glu Lys Asp Arg Asp Ile Met Lys Lys Tyr Leu Pro 
                805                 810                 815     


Asn Asp Lys Asp Arg Glu Gly Tyr Asn Asp Phe Phe Thr Ala Tyr Arg 
            820                 825                 830         


Asn Asn Ile Val His Leu Asn Ile Ile Ala Lys Leu Ser Glu Leu Thr 
        835                 840                 845             


Lys Asn Ile Asp Lys Asp Ile Asn Ser Tyr Phe Asp Ile Tyr His Tyr 
    850                 855                 860                 


Cys Thr Gln Arg Val Met Phe Asp Tyr Cys Lys Met Asn Asn Asn Val 
865                 870                 875                 880 


Val Leu Ala Lys Met Lys Asp Leu Ala His Ile Lys Ser Asp Cys Asp 
                885                 890                 895     


Glu Phe Ser Ser Lys His Thr Tyr Pro Phe Ser Ser Ala Val Leu Arg 
            900                 905                 910         


Phe Met Asn Leu Pro Phe Ala Tyr Asn Val Pro Arg Phe Lys Asn Leu 
        915                 920                 925             


Ser Tyr Lys Lys Phe Phe Asp Lys Gln 
    930                 935         


<210>  2945
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2945

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Phe 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Val Tyr Asn 
                85                  90                  95      


Gln Thr Gln Leu Ser Ser Glu Asp Ser Ser Asn Ile Glu Leu Cys Gly 
            100                 105                 110         


Val Thr Lys Val Asn Ile Thr Phe Ser Ser Lys His Gly Leu Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Ser Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Phe Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ser Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser 
        195                 200                 205             


His Asp Asp Phe Ile Gly Tyr Leu Ser Thr Asn Asn Ile Tyr Asp Val 
    210                 215                 220                 


Phe Ile Asp Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn 
225                 230                 235                 240 


Val Arg Lys Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Cys Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Ile Ile Asp Pro Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Pro Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Lys Val Ala Glu Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2946
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2946

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Thr 
            20                  25                  30          


Pro Thr Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Lys Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asn Ser Ser Asn Ile Glu Leu Arg Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Lys Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Glu Ala Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Gly Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2947
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2947

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Gln Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ser Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Lys Arg Pro Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asp Asp Lys Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  2948
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2948

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Ile Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Pro Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn His Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2949
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2949

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Gln Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Ser Val Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Gln Asn Thr Tyr Tyr Ile 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val 
            260                 265                 270         


Ser Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu 
    290                 295                 300                 


Tyr Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Val Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Ile Ala Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Leu Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Asn Arg Asp Glu Ser Pro Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asp Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  2950
<211>  928
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2950

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Gln Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Val Tyr Asn 
                85                  90                  95      


Gln Thr Gln Leu Ser Ser Lys Gly Ser Ser Asn Ile Lys Leu Cys Gly 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Asp Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Cys Val Phe His Asp Leu Ser Glu His Ser Glu Tyr 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Asn Ser Lys Lys Val Tyr Arg Glu Cys 
305                 310                 315                 320 


Arg Glu Thr Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn 
                325                 330                 335     


Lys Gly Phe Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp 
            340                 345                 350         


Met Met Lys Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp 
        355                 360                 365             


Phe Ile Val Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Lys Met Leu Asp Glu Tyr Gly Tyr Arg Phe Lys Asp Lys 
385                 390                 395                 400 


Gln Tyr Asp Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu 
                405                 410                 415     


Leu Phe Cys Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu 
            420                 425                 430         


Val Arg Lys Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile 
        435                 440                 445             


Tyr Ala Asp Glu Ala Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe 
    450                 455                 460                 


Glu Asn Ile Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly 
465                 470                 475                 480 


Lys Ala Asp Met Asp Phe Asp Glu Lys Ile Ile Asp Ser Glu Lys Lys 
                485                 490                 495     


Asn Ala Ser Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr 
            500                 505                 510         


Tyr Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile 
        515                 520                 525             


Ser Lys Phe Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser 
    530                 535                 540                 


Ala Val Asn Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn 
545                 550                 555                 560 


Asp Ser Gln Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala 
                565                 570                 575     


Ser Met Arg Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp 
            580                 585                 590         


Ala Leu Thr Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile 
        595                 600                 605             


Ser Glu Ile Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu 
    610                 615                 620                 


Arg Asn Phe Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr 
625                 630                 635                 640 


Leu Ile Lys Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Glu Asn 
                645                 650                 655     


Glu Lys Val Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile 
            660                 665                 670         


Glu Arg Tyr Tyr Lys Ser Cys Val Glu Phe His Asp Met Asn Ser Ser 
        675                 680                 685             


Leu Glu Ala Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser 
    690                 695                 700                 


Phe Asp Asp Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn 
705                 710                 715                 720 


Val Ala Lys Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val 
                725                 730                 735     


Met Tyr Leu Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val 
            740                 745                 750         


Ile Ala Ile His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile 
        755                 760                 765             


Ile Pro Glu Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu 
    770                 775                 780                 


Ser Gln Thr Leu Cys Glu Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn 
785                 790                 795                 800 


Leu Phe Leu Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp 
                805                 810                 815     


Ile Asn Asn Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile 
            820                 825                 830         


Ala His Leu Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile 
        835                 840                 845             


Arg Thr Val Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg 
    850                 855                 860                 


Cys Ile Thr Lys Arg Glu Asp Asp Thr Lys Gln Glu Asp Lys Ile Lys 
865                 870                 875                 880 


Tyr Glu Asp Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val 
                885                 890                 895     


Lys Ala Leu Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn 
            900                 905                 910         


Leu Ser Ile Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925             


<210>  2951
<211>  910
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2951

Met Gln Gln Asn Ser Thr Asp Asn Lys Asn Lys Ile Lys Lys Ser Ala 
1               5                   10                  15      


Ala Lys Ala Val Gly Val Lys Ser Leu Ala Arg Leu Ser Asp Gly Ser 
            20                  25                  30          


Thr Val Phe Ser Ser Phe Gly Lys Gly Ala Ala Ala Glu Leu Glu Ser 
        35                  40                  45              


Leu Ile Thr Gly Gly Glu Ile Arg Lys Leu Ser Asp Lys Ala Ile Leu 
    50                  55                  60                  


Glu Ile Thr Asp Asp Thr Gln Asn Lys Asn Ala Tyr Asn Val Lys Ser 
65                  70                  75                  80  


Tyr Arg Ile Pro Asn Leu Thr Ala Arg Thr Asp Lys Leu Ser Asp Lys 
                85                  90                  95      


Ser Gly Met Asp Asp Leu Gly Phe Lys Arg Glu Leu Glu Leu Glu Val 
            100                 105                 110         


Phe Gly Gln Ser Phe Asp Asp Ser Ile His Ile Gln Ile Ala His Ala 
        115                 120                 125             


Val Phe Asp Ile Gln Lys Ser Leu Ala Ala Val Ile Pro Asn Val Leu 
    130                 135                 140                 


Tyr Thr Leu Asn Asn Leu Asp Arg Ser Tyr Ser Thr Asp Asp Thr Ala 
145                 150                 155                 160 


Gly Lys Lys Asp Ile Ile Gly Asn Thr Leu Asn Tyr Gln His Ser Tyr 
                165                 170                 175     


Asp Asn Phe Asp Lys Glu Lys Leu Gly Glu Phe Thr Glu Tyr Tyr Asn 
            180                 185                 190         


Ala Ala Lys Asp Arg Phe Ser Tyr Phe Pro Asp Ile Leu Cys Val Leu 
        195                 200                 205             


Glu Lys Val Asn Gly Lys Asp Arg Tyr Gln Pro Lys Ser Glu Lys Asp 
    210                 215                 220                 


Ala Phe Asn Val Leu Ser Ser Val Asn Met Leu Arg Asn Ser Leu Phe 
225                 230                 235                 240 


His Phe Ala Gln Lys Ser Asn Asp Gly Lys Ala Arg Ile Ala Val Phe 
                245                 250                 255     


Lys Asn Gln Phe Asp Ser Asp Phe Ser His Ile Thr Ser Thr Val Asn 
            260                 265                 270         


Lys Ile Tyr Ser Ala Lys Ile Ala Gly Val Asn Glu Asn Phe Leu Asn 
        275                 280                 285             


Asn Glu Gly Asn Asn Leu Tyr Ile Ile Leu Asn Ala Thr Asn Trp Asp 
    290                 295                 300                 


Ile Lys Lys Ile Val Pro Gln Leu Tyr Arg Phe Ser Val Leu Lys Ser 
305                 310                 315                 320 


Asp Lys Asn Met Gly Phe Asn Met Arg Arg Leu Arg Glu Phe Ala Val 
                325                 330                 335     


Glu Ser Lys Ser Ile Asp Leu Ser Arg Leu Asn Asp Lys Phe Leu Thr 
            340                 345                 350         


Asn Asn Arg Lys Lys Leu Tyr Lys Val Ile Asp Phe Ile Ile Tyr Tyr 
        355                 360                 365             


His Leu Asn Lys Val Arg Lys Asp Thr Phe Lys Asp Asp Phe Val Ala 
    370                 375                 380                 


Ala Leu Arg Ala Ser Gln Ser Glu Glu Glu Lys Glu Lys Leu Tyr Ala 
385                 390                 395                 400 


Gln Tyr Ser Glu Arg Leu Phe Ala Asp Glu Gly Leu Lys Ser Ala Ile 
                405                 410                 415     


Lys Lys Ala Val Asp Met Ile Ser Asp Thr Lys Ser Ser Ile Phe Lys 
            420                 425                 430         


Lys Lys Thr Pro Leu Asp Lys Ala Leu Ile Glu Asn Ile Lys Val Asn 
        435                 440                 445             


Ser Asp Ala Ser Asp Phe Cys Lys Leu Ile Tyr Val Phe Thr Arg Phe 
    450                 455                 460                 


Leu Asp Gly Lys Glu Ile Asn Ile Leu Leu Asn Ser Leu Ile Lys Lys 
465                 470                 475                 480 


Phe Gln Asp Ile His Ser Phe Asn Thr Thr Val Lys Lys Leu Ser Glu 
                485                 490                 495     


Asn Asn Leu Ile Ile Asn Ala Asp Tyr Val Asp Asp Tyr Ser Leu Phe 
            500                 505                 510         


Glu Gln Ser Gly Thr Val Ala Lys Glu Leu Met Leu Ile Lys Ser Ile 
        515                 520                 525             


Ser Lys Met Asp Phe Gly Leu Asp Asn Ile Asn Leu Ser Phe Met Tyr 
    530                 535                 540                 


Asp Asp Ala Leu Arg Thr Leu Gly Val Ser Asp Glu Asn Leu Pro Glu 
545                 550                 555                 560 


Val Lys Arg Glu Tyr Phe Gly Lys Thr Lys Asn Leu Ser Ala Tyr Ile 
                565                 570                 575     


Arg Asn Asn Val Leu Glu Asn Arg Arg Phe Lys Tyr Val Ile Lys Tyr 
            580                 585                 590         


Ile His Pro Ser Asp Val Gln Lys Ile Ala Cys Asn Lys Ala Ile Ala 
        595                 600                 605             


Gly Phe Val Leu Asn Arg Met Pro Asp Thr Gln Ile Lys Arg Tyr Tyr 
    610                 615                 620                 


Asp Ser Leu Ile Asn Lys Gly Ala Thr Asp Met Lys Ala Gln Ala Lys 
625                 630                 635                 640 


Ala Leu Leu Asp Cys Ile Thr Gly Ile Ser Phe Asp Ala Ile Lys Asp 
                645                 650                 655     


Asp Lys His Leu His Lys Ser Lys Glu Lys Ser Pro Gln Arg Ser Ala 
            660                 665                 670         


Asp Arg Glu Arg Lys Lys Ala Met Leu Thr Leu Tyr Tyr Thr Ile Val 
        675                 680                 685             


Tyr Ile Phe Val Lys Gln Met Leu His Ile Asn Ser Leu Tyr Thr Ile 
    690                 695                 700                 


Gly Phe Phe Tyr Leu Glu Arg Asp Gln Arg Phe Ile Tyr Ser Arg Ala 
705                 710                 715                 720 


Lys Lys Glu Asn Lys Asn Ser Ser Lys Asn Ser Tyr Leu Asn Asp Phe 
                725                 730                 735     


Arg Ser Val Thr Ala Tyr Phe Ile Pro Ser Glu Ile Met Lys Arg Ile 
            740                 745                 750         


Glu Lys Asn Glu Asn Lys Gly Phe Leu Glu Asp Phe Glu Ala Leu Trp 
        755                 760                 765             


Asn Ser Cys Gly Lys Thr Ser Arg Leu Arg Lys Glu Asp Val Leu Leu 
    770                 775                 780                 


Tyr Ala Arg Tyr Ile Ser Pro Asp His Ala Leu Lys Asn Tyr Lys Met 
785                 790                 795                 800 


Ile Leu Asn Ser Tyr Arg Asn Lys Ile Ala His Ile Asn Val Ile Met 
                805                 810                 815     


Ser Ala Gly Lys Tyr Thr Gly Gly Ile Lys Arg Met Asp Ser Tyr Phe 
            820                 825                 830         


Ala Val Phe Gln His Leu Val Gln Cys Asp Ile Leu Ser Asn Pro Asn 
        835                 840                 845             


Asn Ala Asn Cys Phe Lys Ser Glu Ser Leu Lys Pro Leu Leu Leu Asp 
    850                 855                 860                 


Met Arg Phe Asp Gly Thr Asp Glu Lys Leu Tyr Ser Lys Arg Leu Thr 
865                 870                 875                 880 


Arg Ala Leu Asn Ile Pro Phe Gly Tyr Asn Val Pro Arg Tyr Lys Asn 
                885                 890                 895     


Leu Thr Phe Glu Lys Ile Tyr Leu Lys Ser Ser Ile Asn Glu 
            900                 905                 910 


<210>  2952
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2952

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Gln Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ser Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Pro Leu Glu Ala 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Ile Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2953
<211>  923
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2953

Met Phe Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Arg Arg Glu 
1               5                   10                  15      


Ala Gln Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn 
            20                  25                  30          


Ala Val Pro Ala Ile Ala Ala Met His Ala Ala Glu Val Ile Ala Pro 
        35                  40                  45              


Ala Ala Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser 
    50                  55                  60                  


Ile Leu Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly 
65                  70                  75                  80  


Asn Ser Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln 
                85                  90                  95      


Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Gly Val 
            100                 105                 110         


Thr Lys Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly 
        115                 120                 125             


Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser 
    130                 135                 140                 


Pro Val Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg 
145                 150                 155                 160 


Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr 
                165                 170                 175     


Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile 
            180                 185                 190         


Val Tyr Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr 
        195                 200                 205             


Asp Phe Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr 
    210                 215                 220                 


Asn Pro Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg 
225                 230                 235                 240 


Lys Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly 
                245                 250                 255     


Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu 
            260                 265                 270         


Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile 
        275                 280                 285             


Arg Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu 
    290                 295                 300                 


Tyr Ser Phe Ile Asn Asn Ile Tyr Pro Glu Tyr Arg Asp Thr Leu Asp 
305                 310                 315                 320 


Tyr Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Gln 
                325                 330                 335     


Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr 
            340                 345                 350         


Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys 
        355                 360                 365             


Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met 
    370                 375                 380                 


Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val 
385                 390                 395                 400 


Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr 
                405                 410                 415     


Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg 
            420                 425                 430         


Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala 
        435                 440                 445             


Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp 
    450                 455                 460                 


His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp 
465                 470                 475                 480 


Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu 
                485                 490                 495     


Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly 
            500                 505                 510         


Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn 
        515                 520                 525             


Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu 
    530                 535                 540                 


Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile 
545                 550                 555                 560 


Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro 
                565                 570                 575     


Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu 
            580                 585                 590         


Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys 
        595                 600                 605             


Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr 
    610                 615                 620                 


Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala 
625                 630                 635                 640 


Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met 
                645                 650                 655     


Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys 
            660                 665                 670         


Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg 
        675                 680                 685             


Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys 
    690                 695                 700                 


Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg 
705                 710                 715                 720 


Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val 
                725                 730                 735     


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys 
            740                 745                 750         


Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala 
        755                 760                 765             


Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys 
    770                 775                 780                 


Glu Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys 
785                 790                 795                 800 


Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp 
                805                 810                 815     


Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val 
            820                 825                 830         


Val Arg Glu Leu Lys Lys Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser 
        835                 840                 845             


Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg 
    850                 855                 860                 


Glu Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu 
865                 870                 875                 880 


Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser 
                885                 890                 895     


Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln 
            900                 905                 910         


Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920             


<210>  2954
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2954

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Ile Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Pro Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn His Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2955
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2955

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asn Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Gln Asn Thr Tyr Tyr Ile Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Ile Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Asp Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Thr Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Glu Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Val Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2956
<211>  926
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2956

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asp Asp Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Ser Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Phe Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Asp Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Lys Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Cys Val Phe His Asp Lys Ser Ser Lys Leu His Glu 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe 
                325                 330                 335     


Ile Glu Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Asp Asp Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile 
        355                 360                 365             


Val Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg 
    370                 375                 380                 


Glu Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe 
                405                 410                 415     


Cys Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg 
            420                 425                 430         


Lys Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala 
        435                 440                 445             


Asp Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn 
    450                 455                 460                 


Ile Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala 
465                 470                 475                 480 


Asp Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala 
                485                 490                 495     


Ser Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe 
            500                 505                 510         


Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys 
        515                 520                 525             


Phe Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val 
    530                 535                 540                 


Asp Val Glu Cys Lys Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser 
545                 550                 555                 560 


Gln Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met 
                565                 570                 575     


Arg Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu 
            580                 585                 590         


Thr Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu 
        595                 600                 605             


Ile Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn 
    610                 615                 620                 


Phe Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile 
625                 630                 635                 640 


Lys Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys 
                645                 650                 655     


Val Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg 
            660                 665                 670         


Tyr Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu 
        675                 680                 685             


Ala Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp 
    690                 695                 700                 


Asp Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala 
705                 710                 715                 720 


Lys Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr 
                725                 730                 735     


Leu Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala 
            740                 745                 750         


Ile His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro 
        755                 760                 765             


Glu Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln 
    770                 775                 780                 


Thr Leu Cys Glu Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe 
785                 790                 795                 800 


Leu Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn 
                805                 810                 815     


Asn Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His 
            820                 825                 830         


Leu Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr 
        835                 840                 845             


Val Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile 
    850                 855                 860                 


Thr Lys Arg Glu Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu 
865                 870                 875                 880 


Asp Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala 
                885                 890                 895     


Leu Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser 
            900                 905                 910         


Ile Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925     


<210>  2957
<211>  954
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2957

Met Gly Lys Lys Ile His Ala Arg Asp Leu Arg Glu Gln Arg Lys Thr 
1               5                   10                  15      


Asp Arg Thr Glu Lys Phe Ala Asp Gln Asn Lys Lys Arg Glu Ala Glu 
            20                  25                  30          


Arg Ala Val Gln Lys Lys Asp Ala Ala Val Ser Val Lys Ser Val Ser 
        35                  40                  45              


Ser Val Ser Ser Lys Lys Asp Asn Val Thr Lys Ser Met Ala Lys Ala 
    50                  55                  60                  


Ala Gly Val Lys Ser Val Phe Ala Val Gly Asn Thr Val Tyr Met Thr 
65                  70                  75                  80  


Ser Phe Gly Arg Gly Asn Asp Ala Val Leu Glu Gln Lys Ile Val Asp 
                85                  90                  95      


Thr Ser His Glu Pro Leu Asn Ile Asp Asp Pro Ala Tyr Gln Leu Asn 
            100                 105                 110         


Val Val Thr Met Asn Gly Tyr Ser Val Thr Gly His Arg Gly Glu Thr 
        115                 120                 125             


Val Ser Ala Val Thr Asp Asn Pro Leu Arg Arg Phe Asn Gly Gly Lys 
    130                 135                 140                 


Lys Asp Glu Pro Glu Gln Ser Val Pro Thr Asp Met Leu Cys Leu Lys 
145                 150                 155                 160 


Pro Thr Leu Glu Lys Lys Phe Phe Gly Lys Glu Phe Asn Asp Asn Ile 
                165                 170                 175     


His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala 
            180                 185                 190         


Val Tyr Ser Thr Asn Ala Ile Tyr Ala Leu Asn Asn Met Ser Ala Asp 
        195                 200                 205             


Glu Asn Ile Glu Asn Ser Asp Phe Phe Met Lys Arg Thr Thr Asp Glu 
    210                 215                 220                 


Thr Phe Asp Asp Phe Glu Lys Lys Lys Glu Ser Thr Asn Ser Arg Glu 
225                 230                 235                 240 


Lys Ala Asp Phe Asp Ala Phe Glu Lys Phe Ile Gly Asn Tyr Arg Leu 
                245                 250                 255     


Ala Tyr Phe Ala Asp Ala Phe Tyr Val Asn Lys Lys Asn Pro Lys Gly 
            260                 265                 270         


Lys Ala Arg Asn Val Leu Arg Glu Asp Lys Glu Leu Tyr Ser Val Leu 
        275                 280                 285             


Thr Leu Ile Gly Lys Leu Arg His Trp Cys Val His Ser Glu Glu Gly 
    290                 295                 300                 


Arg Ala Glu Phe Trp Leu Tyr Lys Leu Asp Glu Leu Lys Asp Asp Phe 
305                 310                 315                 320 


Lys Asn Val Leu Asp Val Val Tyr Asn Arg Pro Val Glu Glu Ile Asn 
                325                 330                 335     


Asn Arg Phe Ile Glu Asn Asn Lys Val Asn Ile Gln Ile Leu Gly Ser 
            340                 345                 350         


Val Tyr Lys Asn Thr Asp Ile Ala Glu Leu Val Arg Ser Tyr Tyr Glu 
        355                 360                 365             


Phe Leu Ile Thr Lys Lys Tyr Lys Asn Met Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Ser Met Leu Glu Gly Lys Gly Tyr Ala Asp Lys Glu Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Asn Lys Leu Tyr Gln Met Thr Asp Phe Ile Leu Tyr 
                405                 410                 415     


Thr Gly Tyr Ile Asn Glu Asp Ser Asp Arg Ala Asp Asp Leu Val Asn 
            420                 425                 430         


Thr Leu Arg Ser Ser Leu Lys Glu Asp Asp Lys Thr Thr Val Tyr Cys 
        435                 440                 445             


Lys Glu Ala Asp Tyr Leu Trp Lys Lys Tyr Arg Glu Ser Ile Arg Glu 
    450                 455                 460                 


Val Ala Asp Ala Leu Asp Val Asp Asn Ile Lys Asn Leu Ser Gly Ser 
465                 470                 475                 480 


Asn Ile Glu Ile Arg Asp Asn Glu Leu Arg Lys Cys Phe Ile Ser Tyr 
                485                 490                 495     


Ala Asp Ser Val Ser Glu Phe Thr Lys Leu Ile Tyr Leu Leu Thr Arg 
            500                 505                 510         


Phe Leu Ser Gly Lys Glu Ile Asn Asp Leu Val Thr Thr Leu Ile Asn 
        515                 520                 525             


Lys Phe Asp Asn Ile Arg Ser Phe Leu Glu Ile Leu Asp Glu Leu Gly 
    530                 535                 540                 


Leu Asp Arg Thr Phe Thr Ala Glu Tyr Ser Phe Phe Glu Gly Ser Thr 
545                 550                 555                 560 


Lys Tyr Leu Ala Glu Leu Val Glu Leu Asn Ser Phe Val Lys Ser Cys 
                565                 570                 575     


Ser Phe Asp Ile Asn Ala Lys Arg Thr Met Tyr Arg Asp Ala Leu Asp 
            580                 585                 590         


Ile Leu Gly Ile Lys Ser Gly Lys Thr Glu Glu Asp Ile Glu Lys Met 
        595                 600                 605             


Ile Asp Asn Ile Leu Gln Ile Asp Ala Asn Gly Asp Lys Lys Leu Lys 
    610                 615                 620                 


Lys Asn Asn Gly Leu Arg Asn Phe Ile Ala Ser Asn Val Ile Asp Ser 
625                 630                 635                 640 


Asn Arg Phe Lys Tyr Leu Val Arg Tyr Gly Asn Pro Lys Lys Ile Arg 
                645                 650                 655     


Glu Thr Ala Lys Cys Lys Pro Ala Val Arg Phe Val Leu Asn Glu Ile 
            660                 665                 670         


Pro Asp Ala Gln Ile Glu Arg Tyr Tyr Glu Ala Cys Cys Pro Lys Asn 
        675                 680                 685             


Thr Ala Leu Cys Ser Ala Asn Lys Arg Arg Glu Lys Leu Ala Asp Met 
    690                 695                 700                 


Ile Ala Glu Ile Lys Phe Glu Asn Phe Ser Asp Ala Gly Asn Tyr Gln 
705                 710                 715                 720 


Lys Ala Asn Val Thr Ser Arg Thr Ser Glu Ala Glu Ile Lys Arg Lys 
                725                 730                 735     


Asn Gln Ala Ile Ile Arg Leu Tyr Leu Thr Val Met Tyr Ile Met Leu 
            740                 745                 750         


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Phe His Cys 
        755                 760                 765             


Val Glu Arg Asp Thr Lys Leu Tyr Ala Glu Ser Gly Leu Glu Val Gly 
    770                 775                 780                 


Asn Ile Glu Lys Asn Lys Thr Asn Leu Thr Met Ala Val Ile Gly Val 
785                 790                 795                 800 


Lys Leu Glu Asn Gly Ile Ile Lys Thr Glu Phe Asp Lys Ser Leu Ala 
                805                 810                 815     


Glu Asn Ala Ala Asn Arg Tyr Leu Arg Asn Ala Arg Trp Tyr Lys Leu 
            820                 825                 830         


Ile Leu Asp Asn Leu Lys Lys Ser Glu Arg Ala Val Val Asn Glu Phe 
        835                 840                 845             


Arg Asn Thr Val Cys His Leu Asn Ala Ile Arg Asn Ile Asn Ile Asn 
    850                 855                 860                 


Ile Lys Glu Ile Lys Glu Val Glu Asn Tyr Phe Ala Leu Tyr His Tyr 
865                 870                 875                 880 


Leu Ile Gln Lys His Leu Glu Asn Arg Phe Ala Asp Lys Lys Val Glu 
                885                 890                 895     


Arg Asp Thr Gly Asp Phe Ile Ser Lys Leu Glu Glu His Lys Thr Tyr 
            900                 905                 910         


Cys Lys Asp Phe Val Lys Ala Tyr Cys Thr Pro Phe Gly Tyr Asn Leu 
        915                 920                 925             


Val Arg Tyr Lys Asn Leu Thr Ile Asp Gly Leu Phe Asp Lys Asn Tyr 
    930                 935                 940                 


Pro Gly Lys Asp Asp Ser Asp Lys Gln Lys 
945                 950                 


<210>  2958
<211>  1025
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2958

Met Ala Lys Lys Ile Thr Ala Lys Gln Lys Arg Glu Glu Lys Glu Arg 
1               5                   10                  15      


Leu Asn Lys Gln Lys Trp Ala Lys Gln Asp Thr Pro Val Val Pro Lys 
            20                  25                  30          


Ser Lys Thr Glu Glu Lys Pro Val Ala Ala Ser Asp Asp Lys Leu Leu 
        35                  40                  45              


Lys Thr Thr Gln Val Lys Lys Val Gln Thr Lys Ser Lys Ala Lys Ala 
    50                  55                  60                  


Met Gly Leu Lys Thr Val Leu Ser Phe Asp Asp Lys Ile Ala Ile Ala 
65                  70                  75                  80  


Ser Phe Val Asn Asp Lys Lys Thr Lys Leu Pro His Ile Glu Arg Val 
                85                  90                  95      


Thr Asp Lys Ser Gly Thr Thr Ile His Glu Asn Ala Arg Met Phe Asp 
            100                 105                 110         


Ser Ser Val Asp Glu Gln Asn Val Asn Ile Glu Lys Arg Met Thr Ile 
        115                 120                 125             


Glu Glu Lys Gln Asn Asp Gly Thr Phe Lys Lys Asp Glu Ile Asp Val 
    130                 135                 140                 


Lys Ala Thr Val Cys Asn Pro Tyr Phe Lys Thr Cys Gly Lys Asp Tyr 
145                 150                 155                 160 


Ile Gly Ile Lys Asp Val Ala Glu Lys Tyr Phe Phe Gly Lys Thr Phe 
                165                 170                 175     


Pro Asn Glu Asn Leu Arg Val Gln Ile Ala Tyr Asn Val Phe Asp Ile 
            180                 185                 190         


Gln Lys Ile Leu Gly Thr Tyr Val Asn Asn Ile Ile Tyr Ser Phe Tyr 
        195                 200                 205             


Asn Leu Arg Arg Asp Gly Lys Ser Asp Val Asp Ile Ile Gly Ser Leu 
    210                 215                 220                 


Tyr Ala Phe Ala Asp Phe Asp Asn Gln Leu Lys Asp Lys Pro Ala Phe 
225                 230                 235                 240 


Arg Glu Ala Lys Asp Leu Leu Lys Asn Thr Glu Ala Tyr Phe Ser Tyr 
                245                 250                 255     


Phe Gly Asp Val Phe Lys Lys Ser Lys Lys Gly Lys Lys Asp Glu Asn 
            260                 265                 270         


Asn Glu Asp Tyr Glu Lys Asn Leu Arg His Asn Phe Asn Val Leu Arg 
        275                 280                 285             


Val Leu Ser Phe Leu Arg Gln Ile Cys Thr His Ala Tyr Val Lys Cys 
    290                 295                 300                 


Thr Ser Gly Ala Lys Asn Asn Gly Asp Ser Thr Lys Thr Glu Ser Leu 
305                 310                 315                 320 


Asp Ala Leu Phe Asn Ile Thr Glu Tyr Phe Asp Lys Thr Ala Pro Glu 
                325                 330                 335     


Leu Ser Lys Thr Ile Asn Glu Ile Tyr Lys Glu Gly Val Asp Arg Ile 
            340                 345                 350         


Asn Asn Asp Phe Val Thr Asn Gly Lys Asn Asn Leu Tyr Ile Leu Ser 
        355                 360                 365             


Lys Val Tyr Pro Asp Met Gln Arg Asn Glu Leu Val Lys Lys Tyr Tyr 
    370                 375                 380                 


Gln Phe Val Val Cys Lys Glu Gly Asn Asn Val Gly Ile Asn Thr Arg 
385                 390                 395                 400 


Lys Leu Lys Glu Ser Ile Ile Ser Gln Asn Pro Trp Ile Thr Thr Pro 
                405                 410                 415     


Gln Asp Asn Asn Lys Ala Asn Asp Tyr Glu Ser Cys Arg His Lys Leu 
            420                 425                 430         


Tyr Thr Ile Met Cys Phe Ile Leu Val Ala Glu Leu Asp Ala His Glu 
        435                 440                 445             


Ser Ile Arg Asp Asn Met Val Ala Glu Leu Arg Ala Asn Met Asp Gly 
    450                 455                 460                 


Asp Asp Gly Arg Asp Ala Ile Tyr Glu Lys Tyr Ala Lys Asp Ile Tyr 
465                 470                 475                 480 


His Ile Val Lys Asp Lys Leu Leu Ala Met Gln Lys Val Phe Asp Glu 
                485                 490                 495     


Glu Leu Val Pro Val Lys Val Asp Gly Lys Asn Asp Pro Gln Gln Phe 
            500                 505                 510         


Thr His Gly Lys Leu Ser Lys Lys Glu Ile Glu Ser Phe Cys Leu Ser 
        515                 520                 525             


Asp Lys Asn Thr Ser Asp Ile Ala Lys Val Val Tyr Phe Leu Cys Asn 
    530                 535                 540                 


Phe Leu Asp Gly Lys Glu Ile Asn Glu Leu Cys Cys Ala Met Met Asn 
545                 550                 555                 560 


Lys Phe Asp Gly Ile Gly Asp Leu Ile Asp Thr Ala Lys Gln Cys Gly 
                565                 570                 575     


Glu Glu Val Lys Phe Ile Glu Glu Phe Ala Cys Leu Ser Asn Tyr Arg 
            580                 585                 590         


Lys Ile Thr Asn Asp Ile Arg Val Ala Lys Ser Ile Ser Lys Met Lys 
        595                 600                 605             


Asn Lys Val Asn Ile Asp Asn Asp Ile Ile Tyr Leu Asp Ala Ile Glu 
    610                 615                 620                 


Leu Leu Gly Arg Arg Ile Glu Lys Tyr Gln Lys Asp Glu Asn Gly Lys 
625                 630                 635                 640 


Ile Leu Leu Gly Thr Asp Gly Lys Arg Leu Tyr Thr Lys Glu Tyr Lys 
                645                 650                 655     


Asp Phe Asn Asp Met Phe Phe Asn Ala Gly Asn His Lys Val Arg Asn 
            660                 665                 670         


Phe Ile Ala Asn Ser Val Met Lys Ser Lys Trp Phe Phe Tyr Val Val 
        675                 680                 685             


Arg Tyr Asn Lys Pro Ala Glu Cys Gln Ile Ile Met Arg Asn Lys Thr 
    690                 695                 700                 


Leu Val Lys Phe Thr Leu Asp Asp Leu Pro Asp Met Gln Ile Gln Arg 
705                 710                 715                 720 


Tyr Tyr Ser Ser Val Phe Gly Asp Asn Asn Met Pro Ala Val Asp Glu 
                725                 730                 735     


Met Arg Lys Leu Leu Leu Lys Lys Ile Asn Gln Phe Ser Val Arg Gly 
            740                 745                 750         


Phe Leu Asp Glu Ile Val Leu Met Ser Asp Glu Glu Ser Lys Arg Asn 
        755                 760                 765             


Lys Ser Ser Glu Lys Glu Gln Lys Lys Ser Leu Ile Arg Leu Tyr Leu 
    770                 775                 780                 


Thr Ile Ala Tyr Leu Ile Thr Lys Ser Met Val Lys Ile Asn Thr Arg 
785                 790                 795                 800 


Phe Ser Ile Ala Cys Ala Thr Tyr Glu Arg Asp Tyr Ala Leu Leu Cys 
                805                 810                 815     


Gln Ser Glu Met Lys Gly Gly Pro Trp Asp Gly Gly Ala Gln Ala Leu 
            820                 825                 830         


Ala Val Thr Arg Lys Phe Leu Asn His Asp Arg Glu Val Phe Asp Arg 
        835                 840                 845             


Tyr Cys Ala Arg Glu Ala Glu Ile Ala Arg Leu Pro Ile Glu Glu Arg 
    850                 855                 860                 


Lys Pro Leu Arg Lys Ala Asn Asp Lys Leu Leu Lys Gln Thr His Tyr 
865                 870                 875                 880 


Thr Asn His Ser Tyr Thr Tyr Ile Val Asn Asn Leu Asn Ser Phe Thr 
                885                 890                 895     


Asp Ile Asp Tyr Cys Ala Lys Asp Val Gly Leu Pro Ala Pro Asn Asp 
            900                 905                 910         


Lys Asn Asp Asn Ala Ser Ile Leu Gly Glu Met Arg Asn Asp Ile Ala 
        915                 920                 925             


His Leu Asn Ile Val His Asp Met Val Lys Tyr Ile Glu Glu Leu Lys 
    930                 935                 940                 


Asp Ile Ser Ser Tyr Tyr Ala Phe Tyr Cys Tyr Val Leu Gln Arg Arg 
945                 950                 955                 960 


Leu Val Gly Lys Asp Pro Asn Cys Gln Asn Lys Phe Lys Ala Lys Tyr 
                965                 970                 975     


Ala Lys Glu Leu Asn Asp Tyr Gly Thr Tyr Asn Lys Asn Leu Met Trp 
            980                 985                 990         


Met Leu Asn Leu Pro Phe Ala Tyr  Asn Leu Pro Arg Tyr  Lys Asn Leu 
        995                 1000                 1005             


Ser Ser  Glu Phe Leu Phe Tyr  Asp Met Glu Tyr Asn  Lys Lys Asp 
    1010                 1015                 1020             


Asp Glu  
    1025 


<210>  2959
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2959

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asn Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Asp Asp Asp Glu Ser His Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe Thr Asp 
    210                 215                 220                 


Pro Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Asn Ala Leu Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Glu 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Lys Val Ala Glu Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Cys Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Arg Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2960
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2960

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asp Asn Asp Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asn 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Ser Val Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Gln Asn Thr Tyr Tyr Ile 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val 
            260                 265                 270         


Ser Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu 
    290                 295                 300                 


Tyr Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Val Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Ile Ala Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Leu Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2961
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2961

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Gln Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Ser Val Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Gln Asn Thr Tyr Tyr Ile 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val 
            260                 265                 270         


Ser Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu 
    290                 295                 300                 


Tyr Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Val Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Ile Ala Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Leu Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Asn Arg Asp Glu Ser Pro Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asp Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  2962
<211>  924
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2962

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Lys Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Val 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys Arg Gly Asn Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn 
        195                 200                 205             


Tyr Asp Phe Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe 
    210                 215                 220                 


Thr Asn Pro Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile 
225                 230                 235                 240 


Arg Lys Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu 
                245                 250                 255     


Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser 
            260                 265                 270         


Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln 
        275                 280                 285             


Ile Arg Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp 
    290                 295                 300                 


Leu Tyr Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu 
305                 310                 315                 320 


Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile 
                325                 330                 335     


Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly 
            340                 345                 350         


Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu 
        355                 360                 365             


Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys 
    370                 375                 380                 


Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser 
385                 390                 395                 400 


Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn 
                405                 410                 415     


Tyr Tyr Arg Asn Asp Val Ile Ala Gly Glu Ala Leu Val Arg Lys Leu 
            420                 425                 430         


Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu 
        435                 440                 445             


Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala 
    450                 455                 460                 


Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met 
465                 470                 475                 480 


Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp 
                485                 490                 495     


Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp 
            500                 505                 510         


Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp 
        515                 520                 525             


Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn Val 
    530                 535                 540                 


Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg 
545                 550                 555                 560 


Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys 
                565                 570                 575     


Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile 
            580                 585                 590         


Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu 
        595                 600                 605             


Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile 
    610                 615                 620                 


Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr 
625                 630                 635                 640 


Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val Val 
                645                 650                 655     


Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr 
            660                 665                 670         


Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys 
        675                 680                 685             


Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe 
    690                 695                 700                 


Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu 
705                 710                 715                 720 


Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu 
                725                 730                 735     


Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His 
            740                 745                 750         


Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu 
        755                 760                 765             


Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu 
    770                 775                 780                 


Cys Glu Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys 
785                 790                 795                 800 


Lys Asn Arg Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala 
                805                 810                 815     


Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr 
            820                 825                 830         


Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp 
        835                 840                 845             


Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys 
    850                 855                 860                 


Arg Glu Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp 
865                 870                 875                 880 


Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn 
                885                 890                 895     


Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu 
            900                 905                 910         


Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 


<210>  2963
<211>  923
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2963

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Val Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Glu Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asn Ser Ser Asn Ile Glu Leu Arg Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Gly Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu His Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Asp Asp Tyr 
            340                 345                 350         


Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys 
        355                 360                 365             


Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met 
    370                 375                 380                 


Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val 
385                 390                 395                 400 


Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr 
                405                 410                 415     


Tyr Arg Asn Asp Val Ile Ala Gly Glu Ala Leu Val Arg Lys Leu Arg 
            420                 425                 430         


Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala 
        435                 440                 445             


Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp 
    450                 455                 460                 


His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp 
465                 470                 475                 480 


Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu 
                485                 490                 495     


Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly 
            500                 505                 510         


Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn 
        515                 520                 525             


Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn Val Glu 
    530                 535                 540                 


Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile 
545                 550                 555                 560 


Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro 
                565                 570                 575     


Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu 
            580                 585                 590         


Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys 
        595                 600                 605             


Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr 
    610                 615                 620                 


Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala 
625                 630                 635                 640 


Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met 
                645                 650                 655     


Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys 
            660                 665                 670         


Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg 
        675                 680                 685             


Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe Lys 
    690                 695                 700                 


Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg 
705                 710                 715                 720 


Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val 
                725                 730                 735     


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys 
            740                 745                 750         


Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala 
        755                 760                 765             


Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys 
    770                 775                 780                 


Glu Leu Cys Asp Asn Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys 
785                 790                 795                 800 


Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp 
                805                 810                 815     


Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val 
            820                 825                 830         


Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser 
        835                 840                 845             


Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg 
    850                 855                 860                 


Glu Asp Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu 
865                 870                 875                 880 


Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser 
                885                 890                 895     


Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln 
            900                 905                 910         


Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920             


<210>  2964
<211>  945
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2964

Met Ala Lys Lys Lys Arg Met Thr Ala Lys Glu Arg Lys Gln Asn His 
1               5                   10                  15      


Arg Glu Ser Leu Met Lys Lys Ala Asp Ser Asn Ala Glu Lys Glu Lys 
            20                  25                  30          


Ala Lys Lys Pro Val Val Glu Asn Lys Pro Asp Thr Ala Ile Ser Lys 
        35                  40                  45              


Asp Asn Lys Pro Lys Pro Asn Lys Glu Ile Lys Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Ala Gly Val Lys Trp Ile Ile Lys Ala Asn Asp Asp Val Thr Tyr 
65                  70                  75                  80  


Ile Ser Ser Phe Gly Lys Gly Asn Asn Ser Val Leu Glu Lys Arg Ile 
                85                  90                  95      


Ile Gly Asp Val Ser Gly Asp Val Asn Lys Asp Ser His Met Tyr Val 
            100                 105                 110         


Asn Pro Lys Tyr Thr Lys Lys Asn Tyr Glu Ile Lys Asn Gly Phe Ser 
        115                 120                 125             


Ser Gly Ser Ser Leu Val Thr Tyr Pro Asn Lys Pro Asp Lys Asn Ser 
    130                 135                 140                 


Gly Met Asp Ala Leu Cys Leu Lys Pro Tyr Phe Glu Ile Asp Phe Phe 
145                 150                 155                 160 


Gly His Ile Phe Thr Asp Asn Met His Ile Gln Ala Ile Tyr Asn Ile 
                165                 170                 175     


Phe Asp Ile Glu Lys Ile Leu Ala Lys His Ile Thr Asn Ile Ile Tyr 
            180                 185                 190         


Thr Val Asn Ser Phe Asp Arg Asn Tyr Asn Gln Ser Gly Asn Asp Thr 
        195                 200                 205             


Ile Gly Phe Asp Leu Asn Tyr Arg Val Pro Tyr Leu Glu Tyr Gly Gly 
    210                 215                 220                 


Gly Lys Asp Ser Asn Gly Lys Pro Asn Lys Ile Ser Ala Trp Lys Lys 
225                 230                 235                 240 


Arg Glu Asn Phe Ile Asn Phe Tyr Asn Glu Ala Lys Pro His Leu Gly 
                245                 250                 255     


Tyr Tyr Glu Asn Ile Phe Tyr Asp His Gly Glu Pro Ile Ser Glu Glu 
            260                 265                 270         


Lys Phe Tyr Asn Tyr Leu Asn Ile Leu Asn Phe Ile Arg Asn Asn Thr 
        275                 280                 285             


Phe His Tyr Lys Asp Asn Asp Ile Glu Leu Tyr Ser Glu Asn Tyr Ser 
    290                 295                 300                 


Glu Glu Tyr Val Phe Ile Asn Cys Leu Asn Glu Phe Val Lys Asn Lys 
305                 310                 315                 320 


Phe Lys Asn Val Asn Lys Asn Phe Ile Ser Asn Glu Lys Asn Asn Leu 
                325                 330                 335     


Tyr Ile Ile Leu Lys Ala Tyr Gly Glu Asp Thr Glu Asn Val Glu Val 
            340                 345                 350         


Val Lys Lys Tyr Ser Lys Glu Leu Tyr Lys Leu Ser Val Leu Lys Thr 
        355                 360                 365             


Asn Lys Asn Leu Gly Val Asn Val Lys Lys Leu Arg Glu Ser Ala Ile 
    370                 375                 380                 


Glu Tyr Gly Tyr Cys Pro Leu Pro Tyr Asp Lys Glu Lys Glu Val Ala 
385                 390                 395                 400 


Lys Leu Ser Ser Val Lys His Lys Leu Tyr Lys Thr Tyr Asp Phe Val 
                405                 410                 415     


Ile Thr His Tyr Leu Asn Ser Asn Asp Lys Leu Leu Leu Glu Ile Val 
            420                 425                 430         


Glu Thr Leu Arg Leu Ser Lys Asn Asp Asp Glu Lys Glu Asn Val Tyr 
        435                 440                 445             


Lys Lys Tyr Ala Glu Lys Leu Phe Lys Ala Asp Asp Val Ile Asn Pro 
    450                 455                 460                 


Ile Lys Ala Ile Ser Lys Leu Phe Ala Glu Lys Gly Asn Lys Leu Phe 
465                 470                 475                 480 


Lys Glu Lys Ile Ile Ile Lys Lys Glu Tyr Ile Glu Asp Val Ser Ile 
                485                 490                 495     


Asp Lys Asn Ile Tyr Asp Phe Thr Lys Val Ile Phe Phe Met Thr Cys 
            500                 505                 510         


Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Asn Ile Ile Ser 
        515                 520                 525             


Lys Leu Gln Val Ile Glu Asp His Asn Asn Val Ile Lys Phe Ile Phe 
    530                 535                 540                 


His Asn Lys Asp Ala Val Tyr Lys Asp Tyr Ser Asp Lys Tyr Ala Ile 
545                 550                 555                 560 


Phe Arg Asn Ala Gly Lys Ile Ala Thr Glu Leu Glu Ala Ile Lys Ser 
                565                 570                 575     


Ile Ala Arg Met Glu Asn Lys Ile Glu Asn Ala Pro Lys Glu Pro Leu 
            580                 585                 590         


Leu Lys Asp Ala Leu Leu Ala Leu Gly Val Ser Ser Asn Asp Phe Asp 
        595                 600                 605             


Glu Lys Tyr Glu Lys Tyr Phe Lys Thr Asp Val Asp Ala Asp Lys Asp 
    610                 615                 620                 


His Gln Lys Val Ser Thr Phe Leu Met Asn Asn Val Ile Asn Asn Ser 
625                 630                 635                 640 


Arg Phe Lys Tyr Val Val Lys Tyr Ile Asn Pro Ala Asp Ile Asn Gly 
                645                 650                 655     


Leu Ala Lys Asn Arg Tyr Leu Val Lys Phe Val Leu Ser Lys Ile Pro 
            660                 665                 670         


Glu Glu Gln Ile Asp Ser Tyr Tyr Lys Leu Phe Ser Asn Glu Glu Glu 
        675                 680                 685             


Pro Ser Cys Glu Glu Lys Ile Lys Leu Leu Thr Lys Lys Ile Ser Lys 
    690                 695                 700                 


Leu Asn Phe Gln Thr Leu Phe Glu Asn Asn Lys Ile Pro Asn Val Glu 
705                 710                 715                 720 


Lys Glu Arg Lys Lys Ala Ile Ile Thr Leu Tyr Phe Thr Ile Val Tyr 
                725                 730                 735     


Ile Leu Val Lys Asn Leu Val Asn Ile Asn Gly Leu Tyr Thr Leu Ala 
            740                 745                 750         


Leu Tyr Phe Val Glu Arg Asp Gly Phe Phe Tyr Lys Gln Ile Cys Glu 
        755                 760                 765             


Lys Lys Leu Ile Glu Thr Leu Lys Lys Lys Asp Lys Lys Gln Leu Tyr 
    770                 775                 780                 


Asn Asp Asp Asp Tyr Leu Leu Leu Pro Glu Ile Phe Ser Gly Ser Lys 
785                 790                 795                 800 


Tyr Arg Glu Glu Thr Lys Asn Leu Lys Leu Pro Lys Glu Lys Asp Arg 
                805                 810                 815     


Asp Ile Met Lys Lys Tyr Leu Pro Asn Asp Lys Asp Arg Glu Glu Tyr 
            820                 825                 830         


Asn Lys Phe Phe Lys Gln Tyr Arg Asn Asn Ile Val His Leu Lys Ile 
        835                 840                 845             


Ile Ala Lys Leu Ser Glu Leu Thr Lys Asn Ile Asp Lys Asp Ile Asn 
    850                 855                 860                 


Ser Tyr Phe Asp Ile Tyr His Tyr Cys Thr Gln Arg Val Met Phe Asp 
865                 870                 875                 880 


Tyr Cys Lys Lys Asn Asn Asn Val Val Leu Ala Lys Met Lys Asp Leu 
                885                 890                 895     


Ala His Ile Lys Ser Asp Cys Asp Glu Phe Ser Ser Lys His Thr Tyr 
            900                 905                 910         


Pro Tyr Ser Ser Ala Val Leu Arg Phe Met Asn Leu Pro Phe Ala Tyr 
        915                 920                 925             


Asn Val Pro Arg Phe Lys Asn Leu Ser Tyr Lys Lys Phe Phe Asp Lys 
    930                 935                 940                 


Gln 
945 


<210>  2965
<211>  900
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2965

Leu Ser Thr Lys Lys Arg Phe Arg Tyr Ser Val Ala Ala Lys Ala Ala 
1               5                   10                  15      


Gly Leu Lys Ser Ser Leu Ala Val Asp Thr Asp Arg Thr Val Met Thr 
            20                  25                  30          


Ser Phe Gly His Gly Asn Ala Ala Ile Leu Glu Lys Glu Ile Val Asp 
        35                  40                  45              


Gly Glu Ile Ser Val Leu Asn Ile Glu Asn Pro Ala Phe Asp Ala Val 
    50                  55                  60                  


Ile Asn Asp Lys Lys Tyr Ala Leu Thr Gly His His Ala Gly Val His 
65                  70                  75                  80  


Ala Leu Val Asp Gln Pro Gln Asn Arg Ser Asp Ala Val His Ile Arg 
                85                  90                  95      


Gly Ala Leu Glu Lys Lys Tyr Phe Gly Asp Thr Phe Ala Asp Asn Ile 
            100                 105                 110         


His Val Gln Ile Ala Tyr Asn Ile Leu Asp Ile Thr Lys Ile Leu Thr 
        115                 120                 125             


Val Tyr Ala Asn Asn Val Val Tyr Ala Leu Asn Asn Leu Val His Ala 
    130                 135                 140                 


Asp Asp Asp Thr Gln Ala Asp Glu Leu Asp Ser Leu Gly Asn Phe Ser 
145                 150                 155                 160 


Ala Gly Thr Ser Tyr Ala Lys Ser Lys Ser Lys Ser Lys Ser Lys Gln 
                165                 170                 175     


Gln Asp Phe Val Glu Leu Phe Ile Lys Lys Lys Glu Ile His Gly Tyr 
            180                 185                 190         


Phe Gly Asp Thr Phe Ala Phe Leu Asp Lys Arg Ile Ala Asp Ala Asp 
        195                 200                 205             


Lys Glu Lys Gln Val Tyr Ala Met Leu Ala Cys Leu Gly Ser Leu Arg 
    210                 215                 220                 


Gln Ala Cys Ser His Tyr Arg Ile Arg Tyr Ser Val Asn Gly Lys Asn 
225                 230                 235                 240 


Val Asp Ala Asp Ala Asp Thr Trp Leu Phe Ser Ser Ala Gln Leu Asp 
                245                 250                 255     


Gln Thr Asp Pro Leu Phe Ser Glu Met Leu Asn Arg Ile Tyr Ser His 
            260                 265                 270         


Lys Ile Lys Thr Val Asn Gln Asn Phe Phe Glu Asn Asn Arg Lys Ala 
        275                 280                 285             


Asn Phe Pro Ile Leu Lys Lys Met Tyr Pro Glu Thr Thr Leu Lys Val 
    290                 295                 300                 


Leu Met Asn Glu Tyr Tyr Asp Phe Ser Ile Arg Lys Gly Tyr Lys Asn 
305                 310                 315                 320 


Phe Gly Phe Ser Ile Lys Ser Leu Arg Glu Ala Leu Leu Ser Pro Gln 
                325                 330                 335     


Tyr Glu Ser Leu Ile Gly Val Gln Ile Lys Asp Asn Lys Glu Tyr Asp 
            340                 345                 350         


Thr Val Arg Ser Lys Leu Tyr Gln Leu Phe Asp Phe Ala Leu Thr Arg 
        355                 360                 365             


Tyr Phe Asn Gln His Pro Asp Met Val Asp Ala Phe Val Val Glu Leu 
    370                 375                 380                 


Arg Ser Leu Ala Lys Asp Glu Asp Ala Lys Asn Ala Val Tyr Glu Lys 
385                 390                 395                 400 


Tyr Ala Lys Ala Val Trp Asn Asp Val Lys Gln Pro Ile Ala Val Met 
                405                 410                 415     


Leu Ser Tyr Met Asn Gly Ser Ala Ile Lys Asn Ile Lys Ala Phe Glu 
            420                 425                 430         


Leu Lys Pro Asp Gln Lys Glu Leu Asn Gly Ile Met Asn Ser Asn Ala 
        435                 440                 445             


Leu Asp Val Pro His Phe Cys Lys Leu Val Tyr Phe Leu Thr Arg Phe 
    450                 455                 460                 


Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Val Asn Lys 
465                 470                 475                 480 


Phe Asp Asn Ile His Ser Phe Asn Gln Val Leu Thr Ala Leu Gly Leu 
                485                 490                 495     


Ser Ala Ser Tyr Glu Ala Asp Tyr Lys Ile Phe Glu Asp Ser Gly Arg 
            500                 505                 510         


Val Val Glu Tyr Leu Arg Glu Ile Asn Ser Phe Ala Arg Met Thr Val 
        515                 520                 525             


Asp Met Glu Lys Ile Lys Arg Ser Ala Tyr Lys Lys Ala Leu Leu Ile 
    530                 535                 540                 


Leu Gly Ser Ser Lys Tyr Ser Asp Glu Asp Leu Asp Ala Arg Val Asp 
545                 550                 555                 560 


Glu Met Leu Gly Val Asp Tyr Asn Gln Asn Gly Glu Lys Ile Lys Val 
                565                 570                 575     


Arg Val Asp Thr Gly Phe Arg Asn Phe Ile Ala Asn Asn Val Val Glu 
            580                 585                 590         


Ser Ser Arg Phe His Tyr Leu Ile Arg Tyr Cys His Pro Arg Lys Ile 
        595                 600                 605             


Arg Asn Leu Ala Gly Asn Ala Ala Leu Ile Glu Tyr Gln Leu Arg Arg 
    610                 615                 620                 


Leu Pro Glu Leu Gln Ile Leu Arg Tyr Tyr Glu Ala Cys Thr Glu Pro 
625                 630                 635                 640 


Ile Lys Arg Thr Ala Arg Thr Met Asp Glu Lys Ile Gly Thr Leu Ile 
                645                 650                 655     


Asp Leu Ile Val Lys Met Asp Phe Ser Gln Phe Glu Asp Val Gln Gln 
            660                 665                 670         


Asn Asp Arg Val Arg Val Phe Ser Asp Ala Glu Lys Lys Glu Lys Ile 
        675                 680                 685             


Arg Lys Met Arg Glu Lys Gln Arg Tyr Gln Ser Ile Ile Ser Leu Tyr 
    690                 695                 700                 


Leu Thr Met Leu Tyr Leu Ile Val Lys Asn Leu Val Asn Ile Asn Ala 
705                 710                 715                 720 


Arg Tyr Val Met Ala Phe Gln Ala Trp Glu Arg Asp Asn Tyr Leu Leu 
                725                 730                 735     


Leu Gln Leu Ser Gly Lys Glu Ala Glu Ala Glu Tyr Leu Asn Leu Thr 
            740                 745                 750         


Arg His Phe Ile Glu Pro Leu Asp Gly Ala Lys Pro Tyr Leu Lys Lys 
        755                 760                 765             


Arg Pro Val Glu Tyr Leu Lys Lys Asp Met Ala Met Val Gly Asn Ser 
    770                 775                 780                 


Ser Ile Arg His Phe Arg Asn Ala Thr Val His Leu Asn Val Ile Met 
785                 790                 795                 800 


Glu Ala His Arg Tyr Thr Lys Asp Ile Lys Tyr Ile Gly Ser Tyr Tyr 
                805                 810                 815     


Ala Leu Tyr His Tyr Ile Leu Gln Arg His Leu Leu Asp Lys Ile Glu 
            820                 825                 830         


Glu Asp Ser Tyr Ala Glu Lys Thr Val Ser Glu Lys Leu Trp Glu Ser 
        835                 840                 845             


Gln Ile Ser Gln Tyr Gly Thr Tyr Ser Lys Asp Phe Val Lys Ala Leu 
    850                 855                 860                 


Cys Cys Pro Phe Gly Tyr Asn Leu Pro Arg Phe Lys Asn Leu Ser Ile 
865                 870                 875                 880 


Glu Gln Leu Phe Asp Arg Asn Glu Ser Lys Glu Ile Thr Asp Ala Thr 
                885                 890                 895     


Ala Pro Arg Gln 
            900 


<210>  2966
<211>  910
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2966

Met Glu Lys Thr Arg Lys Thr Ser Glu Asn Phe Cys Glu Phe Pro Asn 
1               5                   10                  15      


Arg Lys Asn Arg Leu Lys Lys Ser Lys Ser Thr Lys Ala Ala Gly Leu 
            20                  25                  30          


Lys Ser Thr Phe Val Val Asn Asp Lys Leu Leu Val Thr Ser Phe Gly 
        35                  40                  45              


Lys Arg Asn Glu Ala Val Phe Glu Lys Ser Val Glu Asn Glu Ile Ile 
    50                  55                  60                  


Ser Leu Asn Asn Pro Glu Asn Phe Ser Met Glu Arg Ala Gly Lys Lys 
65                  70                  75                  80  


Phe Ser Val Ile Ser Lys Arg Asn Glu Gly Asn Pro Gly Leu Pro Asp 
                85                  90                  95      


Asn Pro Leu Met Ser Ile Lys Glu Ala Gly Glu Asp Val Ile Gly Cys 
            100                 105                 110         


Lys Asp Ile Leu Glu Lys Glu Tyr Phe Gly Lys His Phe Ser Asp Asn 
        115                 120                 125             


Ile His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Lys Lys Ile Leu 
    130                 135                 140                 


Ala Val His Ile Asn Asn Ile Ile Tyr Glu Phe Asp Asn Leu Met Arg 
145                 150                 155                 160 


Asn Asp Thr His Ser Asp Phe Ile Gly Asn Leu Ser Thr Arg Asn Thr 
                165                 170                 175     


Tyr Glu Asn Tyr Ile Asn Pro Ser Pro Thr Leu Ser Glu His Val Arg 
            180                 185                 190         


Lys Ser Ile Glu Lys Ser Arg Glu Tyr Phe Ile Asn Leu Ser Lys Asn 
        195                 200                 205             


Pro Arg Leu Lys Tyr Phe Gly Glu Ile Phe Tyr Lys Pro Val Asn Phe 
    210                 215                 220                 


Lys Asp Lys Arg Asn Lys Lys Thr Val Val Asp Glu Lys Lys Leu Tyr 
225                 230                 235                 240 


Tyr Ile Leu Ala Met Leu Gly Asp Ile Arg Gln Phe Cys Phe His Ala 
                245                 250                 255     


Asn Thr Asn Lys Asn Val Ser Leu Tyr Asn Leu Glu Lys Thr Leu Lys 
            260                 265                 270         


Tyr Glu Ala Lys Asn Ile Leu Asp Ile Ile Tyr Ser Lys Lys Ile Asn 
        275                 280                 285             


Glu Leu Asn Arg Ser Phe Leu Lys Thr Asn Ala Lys Asn Ile Glu Ile 
    290                 295                 300                 


Leu Phe Ala Val Leu Lys Pro Glu Glu Ser Glu Lys Thr Thr Ile Ile 
305                 310                 315                 320 


Lys Asp Phe Tyr Asn Phe Ile Ile Arg Lys Gln Asn Lys Asn Met Gly 
                325                 330                 335     


Phe Ser Leu Lys Lys Leu Arg Glu Gln Met Ile Asp Glu Asn Cys Glu 
            340                 345                 350         


Ile Ile Lys Asp Lys Arg Tyr Asp Ser Val Arg Ser Lys Phe Tyr Arg 
        355                 360                 365             


Leu Leu Asp Phe Ile Ile Phe Glu Tyr Tyr Lys Asn Ala Pro Glu Lys 
    370                 375                 380                 


Ala Asp Tyr Ser Val Leu Tyr Leu Arg Ser Cys Asn Ser Asp Glu Lys 
385                 390                 395                 400 


Lys Asp Leu Phe Tyr Leu Lys Glu Ala Asn Lys Leu Trp Asn Asp Ile 
                405                 410                 415     


Lys Asn Lys Cys Glu Ala Leu Arg Glu Lys Met Lys Gln Ser Glu Ile 
            420                 425                 430         


Gly Lys Ala Ala Ser Asp Thr Leu Ile Ser Glu Thr Met Gln Lys Ser 
        435                 440                 445             


Ile Asp Glu Ile Lys Ile Ser Ser Asp Ser Asp Tyr Phe Gly Lys Leu 
    450                 455                 460                 


Ile Tyr Leu Leu Thr His Phe Ile Asp Gly Lys Glu Ile Asn Asp Leu 
465                 470                 475                 480 


Leu Thr Thr Leu Ile Asn Lys Phe Glu Asn Ile Ala Ser Leu Tyr Ser 
                485                 490                 495     


Val Met Lys Gly Leu Lys Leu Glu Cys Asp Phe Ser Glu Asn Tyr Lys 
            500                 505                 510         


Phe Phe Glu Lys Ser Glu Ser Ile Ser Ala Asp Leu Arg Val Ile Asn 
        515                 520                 525             


Ser Phe Ala Arg Met Thr His Lys Glu Ser Asp Ala Lys Lys Ile Met 
    530                 535                 540                 


Tyr Leu Glu Ala Ala Glu Leu Leu Gly Phe Glu Ala Thr Pro Lys Glu 
545                 550                 555                 560 


Ile Asp Glu Tyr Val Glu Lys Tyr Leu Leu Asn Asp Gln Phe Lys Lys 
                565                 570                 575     


Gly Gln His Asp Phe Arg Asn Phe Ile Ala Ser Asn Val Ile Ser Ser 
            580                 585                 590         


Ser Arg Phe Lys Tyr Leu Ile Arg Tyr Ala Asn Pro Lys Lys Ile Arg 
        595                 600                 605             


Lys Ile Ala Lys Asn Glu Lys Val Val Arg Phe Val Leu Glu Arg Ile 
    610                 615                 620                 


Gly Lys Leu Asn Thr Asn Gln Leu Glu Lys Tyr Tyr Lys Ser Cys Phe 
625                 630                 635                 640 


Gly Ser Glu Cys Asn Asp Lys Glu Lys Ile Ile Ser Ser Leu Thr Asp 
                645                 650                 655     


Ile Ile Leu Lys Met Asp Phe Lys Glu Phe Ser Lys Val Lys Gln Asn 
            660                 665                 670         


Asp Arg Lys Ser Ser Pro Glu Glu Lys Ser Phe Lys Ala Lys Lys Gln 
        675                 680                 685             


Ala Ala Ile Ser Leu Tyr Leu Thr Val Leu Tyr His Phe Val Lys Asn 
    690                 695                 700                 


Ile Ile Asn Val Asn Ser Arg Tyr Thr Ile Ala Phe His Cys Leu Glu 
705                 710                 715                 720 


Arg Asp Met Gln Leu Tyr Gly Met Lys Leu Lys Val Pro Lys Asn Ser 
                725                 730                 735     


Thr Glu Lys Ala Ser Lys Tyr Arg Asp Leu Thr Glu Lys Leu Ile Asn 
            740                 745                 750         


Glu Lys Lys Glu Asn Ile Glu Lys Trp Phe Asn Ser Leu Glu Asn Ser 
        755                 760                 765             


Ser Trp Asn Gln Arg Lys Arg Lys Trp Arg Leu Glu Arg Ser Cys Glu 
    770                 775                 780                 


Tyr Leu Ser Val Asn Leu Lys Asn Ser His Asn Thr Leu Ile Val Arg 
785                 790                 795                 800 


Tyr Arg Asn Asn Ile Glu His Leu Asp Val Ile Ser Asn Ile Asp Lys 
                805                 810                 815     


Tyr Ile Gly Asp Ile Lys Glu Phe Lys Ser Tyr Phe Glu Leu Tyr His 
            820                 825                 830         


Tyr Ile Val Gln Arg Lys Leu Ile Asp Glu Cys Arg Ala Thr Asp Pro 
        835                 840                 845             


Val Lys Met Ala Lys Leu His Glu Asn Ile Glu Lys Phe Ala Glu Pro 
    850                 855                 860                 


Val Leu Ser Tyr Asn Thr Tyr Cys Lys Asp Phe Val Lys Ala Leu Asn 
865                 870                 875                 880 


Ile Pro Phe Gly Tyr Asn Leu Ala Arg Phe Lys Asn Leu Ser Ile Asn 
                885                 890                 895     


Glu Leu Phe Asp Met Asn Glu Lys Asn Glu Asn Glu Asn Gln 
            900                 905                 910 


<210>  2967
<211>  924
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2967

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asn Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Leu Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Leu Ser Glu His Ser Glu Tyr Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asp Asn Ser Lys Lys Val Tyr Arg Glu Cys Arg Glu Thr Leu 
305                 310                 315                 320 


Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile 
                325                 330                 335     


Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly 
            340                 345                 350         


Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu 
        355                 360                 365             


Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys 
    370                 375                 380                 


Ile Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser 
385                 390                 395                 400 


Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn 
                405                 410                 415     


Tyr Tyr Arg Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu 
            420                 425                 430         


Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu 
        435                 440                 445             


Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala 
    450                 455                 460                 


Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met 
465                 470                 475                 480 


Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp 
                485                 490                 495     


Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp 
            500                 505                 510         


Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp 
        515                 520                 525             


Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val 
    530                 535                 540                 


Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg 
545                 550                 555                 560 


Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys 
                565                 570                 575     


Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile 
            580                 585                 590         


Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu 
        595                 600                 605             


Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile 
    610                 615                 620                 


Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr 
625                 630                 635                 640 


Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val 
                645                 650                 655     


Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr 
            660                 665                 670         


Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys 
        675                 680                 685             


Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe 
    690                 695                 700                 


Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu 
705                 710                 715                 720 


Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu 
                725                 730                 735     


Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His 
            740                 745                 750         


Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu 
        755                 760                 765             


Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu 
    770                 775                 780                 


Cys Glu Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys 
785                 790                 795                 800 


Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala 
                805                 810                 815     


Asp Ser Asn Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr 
            820                 825                 830         


Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp 
        835                 840                 845             


Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys 
    850                 855                 860                 


Arg Glu Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp 
865                 870                 875                 880 


Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn 
                885                 890                 895     


Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu 
            900                 905                 910         


Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 


<210>  2968
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2968

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Lys Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asn Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asp Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Phe Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Glu 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Gln Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr 
    850                 855                 860                 


Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  2969
<211>  954
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2969

Met Gly Lys Lys Ile His Ala Arg Asp Leu Arg Glu Gln Arg Lys Thr 
1               5                   10                  15      


Asp Arg Thr Glu Lys Phe Ala Asp Gln Asn Lys Lys Arg Glu Ala Glu 
            20                  25                  30          


Arg Ala Val Gln Lys Lys Asp Ala Ala Val Ser Val Lys Ser Val Ser 
        35                  40                  45              


Ser Val Ser Ser Lys Lys Asp Asn Val Thr Lys Ser Met Ala Lys Ala 
    50                  55                  60                  


Ala Gly Val Lys Ser Val Phe Ala Val Gly Asn Thr Val Tyr Met Thr 
65                  70                  75                  80  


Ser Phe Gly Arg Gly Asn Asp Ala Val Leu Glu Gln Lys Ile Val Asp 
                85                  90                  95      


Thr Ser His Glu Pro Leu Asn Ile Asp Asp Pro Ala Tyr Gln Leu Asn 
            100                 105                 110         


Val Val Thr Met Asn Gly Tyr Ser Val Thr Gly His Arg Gly Glu Thr 
        115                 120                 125             


Val Ser Ala Val Thr Asp Asn Pro Leu Arg Arg Phe Asn Gly Gly Lys 
    130                 135                 140                 


Lys Asp Glu Pro Glu Gln Ser Val Pro Thr Asp Met Leu Cys Leu Lys 
145                 150                 155                 160 


Pro Thr Leu Glu Lys Lys Phe Phe Gly Lys Glu Phe Asn Asp Asn Ile 
                165                 170                 175     


His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala 
            180                 185                 190         


Val Tyr Ser Thr Asn Ala Ile Tyr Ala Leu Asn Asn Met Ser Ala Asp 
        195                 200                 205             


Glu Asn Ile Glu Asn Ser Asp Phe Phe Met Lys Arg Thr Thr Asp Glu 
    210                 215                 220                 


Thr Phe Asp Asp Phe Glu Lys Lys Lys Glu Ser Thr Asn Ser Arg Glu 
225                 230                 235                 240 


Lys Ala Asp Phe Asp Ala Phe Glu Lys Phe Ile Gly Asn Tyr Arg Leu 
                245                 250                 255     


Ala Tyr Phe Ala Asp Ala Phe Tyr Val Asn Lys Lys Asn Pro Lys Gly 
            260                 265                 270         


Lys Ala Lys Asn Val Leu Arg Glu Asp Lys Glu Leu Tyr Ser Val Leu 
        275                 280                 285             


Thr Leu Ile Gly Lys Leu Arg His Trp Cys Val His Ser Glu Asp Gly 
    290                 295                 300                 


Arg Ala Glu Phe Trp Leu Tyr Lys Leu Asp Glu Leu Lys Asp Asp Phe 
305                 310                 315                 320 


Lys Asn Val Leu Asp Val Val Tyr Asn Arg Pro Val Glu Glu Ile Asn 
                325                 330                 335     


Asn Arg Phe Ile Glu Asn Asn Lys Val Asn Ile Gln Ile Leu Gly Ser 
            340                 345                 350         


Val Tyr Lys Asn Thr Asp Ile Ala Glu Leu Val Arg Ser Tyr Tyr Glu 
        355                 360                 365             


Phe Leu Ile Thr Lys Lys Tyr Lys Asn Met Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Ser Met Leu Glu Gly Lys Gly Tyr Ala Asp Lys Glu Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Asn Lys Leu Tyr Gln Met Thr Asp Phe Ile Leu Tyr 
                405                 410                 415     


Thr Gly Tyr Ile Asn Glu Asp Ser Asp Arg Ala Asp Asp Leu Val Asn 
            420                 425                 430         


Thr Leu Arg Ser Ser Leu Lys Glu Asp Asp Lys Thr Thr Val Tyr Cys 
        435                 440                 445             


Lys Glu Ala Asp Tyr Leu Trp Lys Lys Tyr Arg Glu Ser Ile Arg Glu 
    450                 455                 460                 


Val Ala Asp Ala Leu Asp Val Asp Asn Ile Lys Asn Leu Ser Gly Ser 
465                 470                 475                 480 


Asn Ile Glu Ile Arg Asp Asn Glu Leu Arg Lys Cys Phe Ile Ser Tyr 
                485                 490                 495     


Ala Asp Ser Val Ser Glu Phe Thr Lys Leu Ile Tyr Leu Leu Thr Arg 
            500                 505                 510         


Phe Leu Ser Gly Lys Glu Ile Asn Asp Leu Val Thr Thr Leu Ile Asn 
        515                 520                 525             


Lys Phe Asp Asn Ile Arg Ser Phe Leu Glu Ile Met Asp Glu Leu Gly 
    530                 535                 540                 


Leu Asp Arg Thr Phe Thr Ala Glu Tyr Ser Phe Phe Glu Gly Ser Thr 
545                 550                 555                 560 


Lys Tyr Leu Ala Glu Leu Val Glu Leu Asn Ser Phe Val Lys Ser Cys 
                565                 570                 575     


Ser Phe Asp Ile Asn Ala Lys Arg Thr Met Tyr Arg Asp Ala Leu Asp 
            580                 585                 590         


Ile Leu Gly Ile Lys Ser Gly Lys Thr Glu Glu Asp Ile Glu Lys Met 
        595                 600                 605             


Ile Asp Asn Ile Leu Gln Ile Asp Ala Asn Gly Asp Lys Lys Leu Lys 
    610                 615                 620                 


Lys Asn Asn Gly Leu Arg Asn Phe Ile Ala Ser Asn Val Ile Asp Ser 
625                 630                 635                 640 


Asn Arg Phe Lys Tyr Leu Val Arg Tyr Gly Asn Pro Lys Lys Ile Arg 
                645                 650                 655     


Glu Thr Ala Lys Cys Lys Pro Ala Val Arg Phe Val Leu Asn Glu Ile 
            660                 665                 670         


Pro Asp Ala Gln Ile Glu Arg Tyr Tyr Glu Ala Cys Cys Pro Lys Asn 
        675                 680                 685             


Thr Ala Leu Cys Ser Ala Asn Lys Arg Arg Glu Lys Leu Ala Asp Met 
    690                 695                 700                 


Ile Ala Glu Ile Lys Phe Glu Asn Phe Ser Asp Ala Gly Asn Tyr Gln 
705                 710                 715                 720 


Lys Ala Asn Val Thr Ser Arg Thr Ser Glu Ala Glu Ile Lys Arg Lys 
                725                 730                 735     


Asn Gln Ala Ile Ile Arg Leu Tyr Leu Thr Val Met Tyr Ile Met Leu 
            740                 745                 750         


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Phe His Cys 
        755                 760                 765             


Val Glu Arg Asp Thr Lys Leu Tyr Ala Glu Ser Gly Leu Glu Val Gly 
    770                 775                 780                 


Asn Ile Glu Lys Asn Lys Thr Asn Leu Thr Met Ala Val Met Gly Val 
785                 790                 795                 800 


Lys Leu Glu Asn Gly Thr Ile Lys Thr Glu Phe Asp Lys Ser Leu Ala 
                805                 810                 815     


Glu Asn Ala Ala Asn Arg Tyr Leu Arg Asn Ala Arg Trp Tyr Lys Leu 
            820                 825                 830         


Ile Leu Asp Asn Leu Lys Lys Ser Glu Arg Ala Val Val Thr Glu Phe 
        835                 840                 845             


Arg Asn Thr Val Cys His Leu Asn Ala Ile Arg Asn Ile Asn Ile Asn 
    850                 855                 860                 


Ile Lys Glu Ile Lys Glu Val Glu Asn Tyr Phe Ala Leu Tyr His Tyr 
865                 870                 875                 880 


Leu Ile Gln Lys His Leu Glu Asn Arg Phe Ala Asp Lys Lys Val Glu 
                885                 890                 895     


Arg Asp Thr Gly Asp Phe Ile Ser Lys Leu Glu Glu His Lys Thr Tyr 
            900                 905                 910         


Cys Lys Asp Phe Val Lys Ala Tyr Cys Thr Pro Phe Gly Tyr Asn Leu 
        915                 920                 925             


Val Arg Tyr Lys Asn Leu Thr Ile Asp Gly Leu Phe Asp Lys Asn Tyr 
    930                 935                 940                 


Pro Gly Lys Asp Asp Ser Asp Lys Gln Lys 
945                 950                 


<210>  2970
<211>  937
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2970

Met Ala Lys Lys Lys Arg Ile Thr Ala Lys Glu Arg Lys Gln Asn His 
1               5                   10                  15      


Arg Glu Ser Leu Met Lys Lys Ala Asp Ser Asn Ala Glu Lys Glu Lys 
            20                  25                  30          


Ala Lys Lys Pro Val Val Glu Asn Lys Pro Asp Thr Ala Ile Ser Lys 
        35                  40                  45              


Asp Asn Thr Pro Lys Pro Asn Lys Glu Ile Lys Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Ala Gly Val Lys Trp Val Ile Lys Ala Asn Asp Asp Val Ala Tyr 
65                  70                  75                  80  


Ile Ser Ser Phe Gly Lys Gly Asn Asn Ser Val Leu Glu Lys Arg Ile 
                85                  90                  95      


Met Gly Asp Val Ser Ser Asn Val Asn Lys Asp Ser His Met Tyr Val 
            100                 105                 110         


Asn Pro Lys Tyr Thr Lys Lys Asn Tyr Glu Ile Lys Asn Gly Phe Ser 
        115                 120                 125             


Ser Gly Ser Ser Leu Val Thr Tyr Pro Asn Lys Pro Asp Lys Asn Ser 
    130                 135                 140                 


Gly Met Asp Ala Leu Cys Leu Lys Pro Tyr Phe Glu Lys Asp Phe Phe 
145                 150                 155                 160 


Gly His Ile Phe Thr Asp Asn Met His Ile Gln Ala Ile Tyr Asn Ile 
                165                 170                 175     


Phe Asp Ile Glu Lys Ile Leu Ala Lys His Ile Thr Asn Ile Ile Tyr 
            180                 185                 190         


Thr Val Asn Ser Phe Asp Arg Asn Tyr Asn Gln Ser Gly Asn Asp Thr 
        195                 200                 205             


Ile Gly Phe Asp Ile Asn Tyr Arg Val Pro Tyr Ser Glu Tyr Gly Gly 
    210                 215                 220                 


Gly Lys Asp Ser Asn Gly Glu Pro Lys Asn Gln Ser Lys Trp Lys Lys 
225                 230                 235                 240 


Arg Lys Asn Phe Ile Lys Phe Tyr Asn Lys Ser Lys Pro His Leu Gly 
                245                 250                 255     


Tyr Tyr Glu Asn Ile Phe Tyr Asp His Gly Glu Pro Ile Ser Glu Glu 
            260                 265                 270         


Lys Phe Tyr Asn Tyr Leu Asn Ile Leu Asn Phe Ile Arg Asn Asn Thr 
        275                 280                 285             


Phe His Tyr Lys Asp Asp Asp Ile Glu Leu Tyr Ser Glu Asn Tyr Ser 
    290                 295                 300                 


Glu Glu Phe Val Phe Ile Asn Cys Leu Asn Lys Phe Val Lys Asn Lys 
305                 310                 315                 320 


Phe Lys Asn Val Asn Lys Asn Phe Ile Ser Asn Glu Lys Asn Asn Leu 
                325                 330                 335     


Tyr Ile Ile Leu Asn Ala Tyr Gly Lys Asp Thr Glu Asn Val Glu Val 
            340                 345                 350         


Val Lys Lys Tyr Ser Lys Glu Leu Tyr Lys Leu Ser Val Leu Lys Thr 
        355                 360                 365             


Asn Lys Asn Leu Gly Val Asn Val Lys Lys Leu Arg Glu Ser Ala Ile 
    370                 375                 380                 


Glu Tyr Gly Tyr Cys Pro Leu Pro Tyr Asp Lys Glu Lys Glu Val Ala 
385                 390                 395                 400 


Lys Leu Ser Ser Val Lys His Lys Leu Tyr Lys Thr Tyr Asp Phe Val 
                405                 410                 415     


Ile Thr His Tyr Leu Asn Ser Asn Asp Lys Ile Leu Leu Glu Ile Val 
            420                 425                 430         


Glu Val Leu Arg Leu Ser Lys Asn Asp Asp Glu Lys Glu Asn Val Tyr 
        435                 440                 445             


Lys Lys Tyr Ala Glu Lys Leu Phe Lys Ala Asp Asp Val Ile Asn Pro 
    450                 455                 460                 


Ile Lys Ala Ile Ser Lys Leu Phe Ala Glu Lys Gly Asn Lys Leu Phe 
465                 470                 475                 480 


Lys Glu Lys Ile Ile Ile Lys Lys Glu Tyr Ile Glu Asp Val Ser Ile 
                485                 490                 495     


Asp Lys Asn Ile Tyr Asp Phe Thr Lys Val Ile Phe Phe Met Thr Cys 
            500                 505                 510         


Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Asn Ile Ile Ser 
        515                 520                 525             


Lys Leu Gln Val Ile Glu Asp His Asn Asn Val Ile Lys Phe Ile Ser 
    530                 535                 540                 


His Asn Lys Asp Ala Val Tyr Lys Asp Tyr Ser Asp Lys Tyr Ala Ile 
545                 550                 555                 560 


Phe Arg Asn Ala Gly Lys Ile Ala Thr Glu Leu Glu Ala Ile Lys Ser 
                565                 570                 575     


Ile Ala Arg Met Glu Asn Lys Ile Glu Asn Ala Pro Gln Glu Pro Leu 
            580                 585                 590         


Leu Asn Asp Ala Leu Leu Ala Leu Gly Val Ser Lys Thr Asp Leu Glu 
        595                 600                 605             


Asn Thr Tyr Asn Lys Tyr Phe Asp Ser Lys Glu Lys Thr Asp Lys Gln 
    610                 615                 620                 


Ser Gln Lys Val Ser Thr Phe Leu Met Asn Asn Val Ile Asn Asn Asn 
625                 630                 635                 640 


Arg Phe Lys Tyr Val Ile Lys Tyr Ile Asn Pro Ala Asp Ile Asn Gly 
                645                 650                 655     


Leu Ala Lys Asn Arg Tyr Leu Val Lys Phe Val Leu Ser Lys Ile Pro 
            660                 665                 670         


Glu Glu Gln Ile Asp Ser Tyr Tyr Lys Leu Phe Ser Asn Glu Glu Glu 
        675                 680                 685             


Pro Ser Cys Glu Glu Lys Ile Lys Leu Leu Thr Lys Lys Ile Ser Lys 
    690                 695                 700                 


Leu Asn Phe Gln Thr Leu Phe Glu Asn Asn Lys Ile Pro Asn Val Glu 
705                 710                 715                 720 


Lys Glu Arg Lys Lys Ala Ile Ile Thr Leu Tyr Phe Thr Ile Val Tyr 
                725                 730                 735     


Ile Leu Val Lys Asn Leu Val Asn Ile Asn Gly Leu Tyr Thr Leu Ala 
            740                 745                 750         


Leu Tyr Phe Val Glu Arg Asp Arg Tyr Phe Tyr Lys Lys Ile Cys Gly 
        755                 760                 765             


Lys Ala Leu Arg Arg Lys Val Gly Asp Lys Tyr Asp Tyr Leu Leu Leu 
    770                 775                 780                 


Pro Glu Ile Phe Ser Gly Ser Lys Tyr Arg Glu Glu Thr Lys Asn Leu 
785                 790                 795                 800 


Lys Leu Pro Lys Glu Lys Asp Arg Asp Ile Met Lys Lys Tyr Leu Pro 
                805                 810                 815     


Asn Asp Lys Asp Arg Glu Gly Tyr Asn Asp Phe Phe Thr Ala Tyr Arg 
            820                 825                 830         


Asn Asn Ile Val His Leu Asn Ile Ile Ala Lys Leu Ser Glu Leu Thr 
        835                 840                 845             


Lys Asn Ile Asp Lys Asp Ile Asn Ser Tyr Phe Asp Ile Tyr His Tyr 
    850                 855                 860                 


Cys Thr Gln Arg Val Met Phe Asp Tyr Cys Lys Met Asn Asn Asn Val 
865                 870                 875                 880 


Val Leu Ala Lys Met Lys Asp Leu Ala His Ile Lys Ser Asp Cys Asp 
                885                 890                 895     


Glu Phe Ser Ser Lys His Thr Tyr Pro Phe Ser Ser Ala Val Leu Arg 
            900                 905                 910         


Phe Met Asn Leu Pro Phe Ala Tyr Asn Val Pro Arg Phe Lys Asn Leu 
        915                 920                 925             


Ser Tyr Lys Lys Phe Phe Asp Lys Gln 
    930                 935         


<210>  2971
<211>  921
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2971

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Arg Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Asn Asn Ile Glu Leu Gly Asn Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Asn Arg Val Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asn Asn Ile Tyr Pro Glu Tyr Arg Asp Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Pro 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp 
    370                 375                 380                 


Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Val Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Lys Val Ala Glu Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Ala Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn Lys 
785                 790                 795                 800 


Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Asn 
                805                 810                 815     


Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg 
            820                 825                 830         


Glu Leu Asn Lys Tyr Ile Lys Asp Ile Arg Thr Val Asp Ser Tyr Phe 
        835                 840                 845             


Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp 
    850                 855                 860                 


Asp Lys Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys 
865                 870                 875                 880 


Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe 
                885                 890                 895     


Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe 
            900                 905                 910         


Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920     


<210>  2972
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2972

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Met Lys 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Ile Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Asn Arg Val Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2973
<211>  924
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2973

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Phe Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Leu Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Leu Ser Glu His Ser Glu Tyr Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asp Asn Ser Lys Lys Val Tyr Arg Glu Cys Arg Glu Thr Leu 
305                 310                 315                 320 


Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile 
                325                 330                 335     


Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly 
            340                 345                 350         


Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu 
        355                 360                 365             


Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys 
    370                 375                 380                 


Ile Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser 
385                 390                 395                 400 


Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn 
                405                 410                 415     


Tyr Tyr Arg Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu 
            420                 425                 430         


Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu 
        435                 440                 445             


Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala 
    450                 455                 460                 


Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met 
465                 470                 475                 480 


Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp 
                485                 490                 495     


Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp 
            500                 505                 510         


Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp 
        515                 520                 525             


Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Ile Asp Val 
    530                 535                 540                 


Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg 
545                 550                 555                 560 


Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys 
                565                 570                 575     


Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile 
            580                 585                 590         


Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu 
        595                 600                 605             


Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile 
    610                 615                 620                 


Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr 
625                 630                 635                 640 


Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val 
                645                 650                 655     


Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr 
            660                 665                 670         


Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys 
        675                 680                 685             


Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe 
    690                 695                 700                 


Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu 
705                 710                 715                 720 


Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu 
                725                 730                 735     


Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His 
            740                 745                 750         


Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu 
        755                 760                 765             


Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu 
    770                 775                 780                 


Cys Glu Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys 
785                 790                 795                 800 


Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala 
                805                 810                 815     


Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr 
            820                 825                 830         


Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp 
        835                 840                 845             


Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys 
    850                 855                 860                 


Arg Glu Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp 
865                 870                 875                 880 


Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn 
                885                 890                 895     


Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu 
            900                 905                 910         


Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 


<210>  2974
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2974

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Ser Ser Asn Ile Glu Leu Arg Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Lys Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe Thr Asn 
    210                 215                 220                 


Pro Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Lys Asn Ile Arg Lys 
225                 230                 235                 240 


Ser Leu Arg Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu His Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Ile Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Lys Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Arg Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  2975
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2975

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ile 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Glu Asp Ser Ser Asn Ile Glu Leu Gly Asp Val Asp Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Lys 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Met Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Ser Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr 
    850                 855                 860                 


Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  2976
<211>  952
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2976

Met Gly Lys Lys Ile His Ala Arg Asp Leu Arg Glu Gln Arg Lys Thr 
1               5                   10                  15      


Asp Arg Thr Glu Lys Phe Ala Asp Gln Asn Lys Lys Arg Glu Ala Glu 
            20                  25                  30          


Arg Ala Val Gln Lys Lys Asp Ala Ala Val Ser Val Lys Ser Val Ser 
        35                  40                  45              


Ser Val Ser Ser Lys Lys Asp Asn Val Thr Lys Ser Met Ala Lys Ala 
    50                  55                  60                  


Ala Gly Val Lys Ser Val Phe Ala Val Gly Asn Thr Val Tyr Met Thr 
65                  70                  75                  80  


Ser Phe Gly Arg Gly Asn Asp Ala Val Leu Glu Gln Lys Ile Val Asp 
                85                  90                  95      


Thr Ser His Glu Pro Leu Asn Ile Asp Asp Pro Ala Tyr Gln Leu Asn 
            100                 105                 110         


Val Val Thr Met Asn Gly Tyr Ser Val Thr Gly His Arg Gly Glu Thr 
        115                 120                 125             


Val Ser Ala Val Thr Asp Asn Pro Leu Arg Arg Phe Asn Gly Gly Lys 
    130                 135                 140                 


Lys Asp Glu Pro Glu Gln Ser Val Pro Thr Asp Met Leu Cys Leu Lys 
145                 150                 155                 160 


Pro Thr Leu Glu Lys Lys Phe Phe Gly Lys Glu Phe Asp Asp Asn Ile 
                165                 170                 175     


His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala 
            180                 185                 190         


Val Tyr Ser Thr Asn Ala Ile Tyr Ala Leu Asn Asn Met Ser Ala Asp 
        195                 200                 205             


Glu Asn Ile Glu Asn Ser Asp Phe Phe Met Lys Arg Thr Thr Asp Glu 
    210                 215                 220                 


Thr Phe Asp Asp Phe Glu Lys Lys Lys Glu Ser Thr Asn Ser Arg Glu 
225                 230                 235                 240 


Lys Ala Asp Phe Asp Ala Phe Glu Lys Phe Ile Gly Asn Tyr Arg Leu 
                245                 250                 255     


Ala Tyr Phe Ala Asp Ala Phe Tyr Val Asn Lys Lys Asn Pro Lys Gly 
            260                 265                 270         


Lys Ala Arg Asn Val Leu Arg Glu Asp Lys Glu Leu Tyr Ser Val Leu 
        275                 280                 285             


Thr Leu Ile Gly Lys Leu Arg His Trp Cys Val His Ser Glu Glu Gly 
    290                 295                 300                 


Arg Ala Glu Phe Trp Leu Tyr Lys Leu Asp Glu Leu Lys Asp Asp Phe 
305                 310                 315                 320 


Lys Asn Val Leu Asp Val Val Tyr Asn Arg Pro Val Glu Glu Ile Asn 
                325                 330                 335     


Asn Arg Phe Ile Glu Asn Asn Lys Val Asn Ile Gln Ile Leu Gly Ser 
            340                 345                 350         


Val Tyr Lys Asn Thr Asp Ile Ala Glu Leu Val Arg Ser Tyr Tyr Glu 
        355                 360                 365             


Phe Leu Ile Thr Lys Lys Tyr Lys Asn Met Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Ser Met Leu Glu Gly Lys Gly Tyr Ala Asp Lys Glu Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Asn Lys Leu Tyr Gln Met Thr Asp Phe Ile Leu Tyr 
                405                 410                 415     


Thr Gly Tyr Ile Asn Glu Asp Ser Asp Arg Ala Asp Asp Leu Val Asn 
            420                 425                 430         


Thr Leu Arg Ser Ser Leu Lys Glu Asp Asp Lys Thr Thr Val Tyr Cys 
        435                 440                 445             


Lys Glu Ala Asp Tyr Leu Trp Lys Lys Tyr Arg Glu Ser Ile Arg Glu 
    450                 455                 460                 


Val Ala Asp Ala Leu Asp Gly Asp Asn Ile Lys Arg Leu Ser Lys Ser 
465                 470                 475                 480 


Asn Ile Glu Ile Gln Glu Asp Lys Leu Arg Lys Cys Phe Ile Ser Tyr 
                485                 490                 495     


Ala Asp Ser Val Ser Glu Phe Thr Lys Leu Ile Tyr Leu Leu Thr Arg 
            500                 505                 510         


Phe Leu Ser Gly Lys Glu Ile Asn Asp Leu Val Thr Thr Leu Ile Asn 
        515                 520                 525             


Lys Phe Asp Asn Ile Arg Ser Phe Leu Glu Ile Met Asp Glu Leu Gly 
    530                 535                 540                 


Leu Asp Arg Thr Phe Thr Ala Glu Tyr Ser Phe Phe Glu Gly Ser Thr 
545                 550                 555                 560 


Lys Tyr Leu Ala Glu Leu Val Glu Leu Asn Ser Phe Val Lys Ser Cys 
                565                 570                 575     


Ser Phe Asp Ile Asn Ala Lys Arg Thr Met Tyr Arg Asp Ala Leu Asp 
            580                 585                 590         


Ile Leu Gly Ile Lys Ser Gly Lys Thr Glu Glu Asp Ile Glu Lys Met 
        595                 600                 605             


Ile Asp Asn Ile Leu Gln Ile Asp Ala Asn Gly Asp Lys Lys Leu Lys 
    610                 615                 620                 


Lys Asn Asn Gly Leu Arg Asn Phe Ile Ala Ser Asn Val Ile Asp Ser 
625                 630                 635                 640 


Asn Arg Phe Lys Tyr Leu Val Arg Tyr Gly Asn Pro Lys Lys Ile Arg 
                645                 650                 655     


Glu Thr Ala Lys Cys Lys Pro Ala Val Arg Phe Val Leu Asn Glu Ile 
            660                 665                 670         


Pro Asp Ala Gln Ile Glu Arg Tyr Tyr Glu Ala Cys Cys Pro Lys Asn 
        675                 680                 685             


Thr Ala Leu Cys Ser Ala Asn Lys Arg Arg Glu Lys Leu Ala Asp Met 
    690                 695                 700                 


Ile Ala Glu Ile Lys Phe Glu Asn Phe Ser Asp Ala Gly Asn Tyr Gln 
705                 710                 715                 720 


Lys Ala Asn Val Thr Ser Lys Thr His Glu Ala Glu Ile Lys Arg Lys 
                725                 730                 735     


Asn Gln Ala Ile Ile Arg Leu Tyr Leu Thr Val Met Tyr Ile Met Leu 
            740                 745                 750         


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Phe His Cys 
        755                 760                 765             


Val Glu Arg Asp Thr Lys Leu Tyr Ala Glu Ser Gly Leu Glu Val Gly 
    770                 775                 780                 


Asn Ile Glu Lys Asn Lys Thr Asn Leu Thr Met Ala Val Met Gly Val 
785                 790                 795                 800 


Lys Leu Glu Asn Gly Ile Ile Lys Thr Glu Phe Asp Lys Ser Leu Ala 
                805                 810                 815     


Glu Asn Ala Ala Asn Arg Tyr Leu Arg Asn Ala Arg Trp Tyr Lys Leu 
            820                 825                 830         


Ile Leu Asp Asn Leu Lys Lys Ser Glu Arg Ala Val Val Asn Glu Phe 
        835                 840                 845             


Arg Asn Thr Val Cys His Leu Asn Ala Ile Arg Asn Ile Asn Ile Asn 
    850                 855                 860                 


Ile Asp Gly Ile Lys Glu Val Glu Asn Tyr Phe Ala Leu Tyr His Tyr 
865                 870                 875                 880 


Leu Ile Gln Lys His Leu Glu Asn Arg Phe Ala Asp Asn Gly Gly Ser 
                885                 890                 895     


Thr Gly Asp Tyr Ile Gly Lys Leu Glu Glu His Lys Thr Tyr Cys Lys 
            900                 905                 910         


Asp Phe Val Lys Ala Tyr Cys Thr Pro Phe Gly Tyr Asn Leu Val Arg 
        915                 920                 925             


Tyr Lys Asn Leu Thr Ile Asp Gly Leu Phe Asp Lys Asn Tyr Pro Gly 
    930                 935                 940                 


Lys Asp Asp Ser Asp Glu Gln Lys 
945                 950         


<210>  2977
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2977

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Gln Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Lys Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Arg Gly Val Thr Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Leu Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Asn Arg Val Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Asp Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Ile Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Asp 
    770                 775                 780                 


Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn Lys Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Thr Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp Asp Thr 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  2978
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2978

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Ile Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Pro Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn His Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2979
<211>  984
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2979

Met Lys Lys Lys Asn Ile Arg Ala Thr Arg Glu Ala Leu Lys Ala Gln 
1               5                   10                  15      


Lys Ile Lys Lys Ser Gln Glu Asn Glu Ala Leu Lys Lys Gln Lys Leu 
            20                  25                  30          


Ala Glu Glu Ala Ala Gln Lys Arg Arg Glu Glu Leu Glu Lys Lys Asn 
        35                  40                  45              


Leu Ala Gln Trp Glu Glu Thr Ser Ala Glu Gly Arg Arg Ser Arg Val 
    50                  55                  60                  


Lys Ala Val Gly Val Lys Ser Val Phe Val Val Gly Asp Asp Leu Tyr 
65                  70                  75                  80  


Leu Ala Thr Phe Gly Asn Gly Asn Glu Thr Val Leu Glu Lys Lys Ile 
                85                  90                  95      


Thr Pro Asp Gly Lys Ile Thr Thr Phe Pro Glu Glu Glu Thr Phe Thr 
            100                 105                 110         


Ala Lys Leu Lys Phe Ala Lys Thr Glu Leu Thr Glu Ala Thr Ser Ile 
        115                 120                 125             


Gly Ile Ser Asn Gly Arg Ile Val Leu Pro Glu Ile Ser Val Asp Asn 
    130                 135                 140                 


Pro Leu His Thr Thr Met Gln Lys Asn Thr Ile Lys Lys Ser Ala Gly 
145                 150                 155                 160 


Glu Asp Met Leu Gln Leu Lys Asp Val Leu Glu Asn Arg Tyr Phe Asp 
                165                 170                 175     


Arg Ser Phe Asn Asn Asp Leu His Ile Arg Leu Ile Tyr Asn Ile Leu 
            180                 185                 190         


Asp Ile Glu Lys Ile Leu Ala Glu Tyr Thr Thr Asn Ala Val Phe Ala 
        195                 200                 205             


Ile Asp Asn Val Ser Gly Cys Ser Asp Asp Phe Leu Ser Asn Phe Ser 
    210                 215                 220                 


Thr Arg Asn Gln Trp Asp Glu Phe Gln Asn Pro Glu Gln His Arg Glu 
225                 230                 235                 240 


His Phe Gly Asn Lys Asp Asn Val Ile Cys Ser Val Lys Lys Gln Gln 
                245                 250                 255     


Asp Leu Phe Phe Asn Phe Phe Lys Asn Asn Arg Ile Gly Tyr Phe Gly 
            260                 265                 270         


Lys Ala Phe Phe His Ala Glu Ser Glu Arg Lys Ile Val Lys Lys Thr 
        275                 280                 285             


Ala Lys Glu Val Tyr His Ile Leu Thr Leu Ile Gly Ser Leu Arg Gln 
    290                 295                 300                 


Trp Ile Thr His Ser Thr Glu Gly Gly Ile Ser Arg Leu Trp Leu Tyr 
305                 310                 315                 320 


Gln Leu Glu Asp Ala Leu Ser Ser Glu Tyr Gln Glu Thr Met Asn Asn 
                325                 330                 335     


Cys Tyr Asn Ser Thr Ile Tyr Gly Leu Gln Lys Asp Phe Glu Lys Thr 
            340                 345                 350         


Asn Ala Pro Asn Leu Asn Phe Leu Ala Glu Ile Leu Gly Glu Asn Ala 
        355                 360                 365             


Ser Glu Leu Ala Glu Pro Tyr Phe Arg Phe Ile Ile Thr Lys Glu Tyr 
    370                 375                 380                 


Lys Asn Leu Gly Phe Ser Ile Lys Thr Leu Arg Glu Met Leu Leu Asp 
385                 390                 395                 400 


Gln Pro Asp Leu Gln Glu Ile Arg Glu Asn His Asn Val Tyr Asp Ser 
                405                 410                 415     


Ile Arg Ser Lys Leu Tyr Lys Met Met Asp Phe Val Leu Val Tyr Ala 
            420                 425                 430         


Tyr Ser Asn Glu Arg Lys Ser Lys Ala Asp Ala Leu Ala Ser Asn Leu 
        435                 440                 445             


Arg Ser Ala Ile Thr Glu Asp Ala Lys Lys Arg Val Tyr Gln Asn Glu 
    450                 455                 460                 


Ala Asp Gln Leu Trp Thr Ser Tyr Gln Glu Leu Phe Lys Arg Ile Arg 
465                 470                 475                 480 


Gly Phe Lys Gly Ala Gln Val Lys Glu Tyr Ser Ser Gln Asn Met Pro 
                485                 490                 495     


Ile Pro Ile Gln Lys Gln Ile Gln Asn Ile Leu Lys Pro Ala Glu Gln 
            500                 505                 510         


Val Thr Cys Phe Thr Lys Leu Met Tyr Leu Leu Thr Met Phe Leu Asp 
        515                 520                 525             


Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp 
    530                 535                 540                 


Asn Ile Ser Ser Leu Leu Lys Thr Met Glu Gln Leu Glu Leu Gln Thr 
545                 550                 555                 560 


Thr Phe Lys Glu Asp Tyr Thr Phe Phe Gln Gln Ser Ser Cys Leu Cys 
                565                 570                 575     


Glu Glu Ile Thr Gln Leu Lys Ser Phe Ala Arg Met Gly Asn Pro Ile 
            580                 585                 590         


Ser Asn Leu Lys Glu Val Met Met Val Asp Ala Ile Gln Ile Leu Gly 
        595                 600                 605             


Thr Glu Lys Ser Glu Gln Glu Leu Gln Ser Met Ala Cys Phe Phe Phe 
    610                 615                 620                 


Arg Asp Lys Asn Gly Lys Lys Leu Asn Ala Gly Glu His Gly Met Arg 
625                 630                 635                 640 


Asn Phe Ile Gly Asn Asn Val Ile Ser Asn Thr Arg Phe Gln Tyr Leu 
                645                 650                 655     


Ile Arg Tyr Gly Asn Pro Gln Lys Leu His Thr Leu Ser Gln Asn Glu 
            660                 665                 670         


Thr Val Val Arg Phe Val Leu Ser Arg Ile Ala Lys Asn Gln Arg Val 
        675                 680                 685             


Gln Gly Met Asn Gly Lys Asn Gln Ile Asp Arg Tyr Tyr Glu Thr Cys 
    690                 695                 700                 


Gly Gly Thr Asn Ser Trp Ser Val Ser Glu Glu Glu Lys Ile Asn Phe 
705                 710                 715                 720 


Leu Cys Lys Ile Leu Thr Asn Met Ser Tyr Asp Gln Phe Gln Asp Val 
                725                 730                 735     


Lys Gln Ser Asp Lys Ile Ile Thr Ala Glu Glu Lys Arg Lys Lys Glu 
            740                 745                 750         


Arg Tyr Lys Ala Ile Ile Ser Leu Tyr Leu Thr Val Leu Tyr Gln Leu 
        755                 760                 765             


Ile Lys Asn Leu Val Asn Ile Asn Ala Arg Tyr Ile Ile Ala Phe His 
    770                 775                 780                 


Cys Leu Glu Arg Asp Ala Ile Leu Tyr Ser Leu Lys Phe Asn Thr Ser 
785                 790                 795                 800 


Ile Asn Leu Lys Lys Arg Tyr Thr Ala Leu Thr Glu Met Ile Leu Gly 
                805                 810                 815     


Tyr Glu Thr Asp Glu Lys Ala Arg Arg Lys Asp Thr Arg Thr Ile Tyr 
            820                 825                 830         


Glu Lys Ala Glu Ala Ala Lys Asn Arg His Leu Lys Asn Val Lys Trp 
        835                 840                 845             


Asn Cys Lys Thr Arg Glu Asn Leu Glu Asn Ala Asp Lys Asn Ala Ile 
    850                 855                 860                 


Val Ala Phe Arg Asn Ile Val Ala His Leu Trp Ile Ile Arg Asp Ala 
865                 870                 875                 880 


Asp Arg Phe Ile Thr Glu Met Gly Ala Met Lys Arg Tyr Phe Asp Cys 
                885                 890                 895     


Tyr His Tyr Leu Leu Gln Arg Glu Leu Glu Tyr Ile Leu Glu Lys Ser 
            900                 905                 910         


Asn Gln Gly Ser Lys Tyr Thr Lys Lys Ser Leu Glu Lys Val Gln Gln 
        915                 920                 925             


Tyr His Ser Tyr Cys Lys Asp Phe Leu His Met Leu Cys Leu Pro Phe 
    930                 935                 940                 


Ala Tyr Cys Ile Pro Arg Tyr Lys Asn Leu Ser Ile Ala Glu Leu Phe 
945                 950                 955                 960 


Asp Arg His Glu Leu Glu Ala Glu Pro Lys Glu Glu Ala Ser Pro Ala 
                965                 970                 975     


Asn Asn Ser Gln Phe Ile Thr Thr 
            980                 


<210>  2980
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2980

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asp Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Gly Asp Glu Ser His Asp Asp 
        195                 200                 205             


Ile Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe Thr Asp 
    210                 215                 220                 


Pro Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Ala Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu Tyr Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Ile Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Met Gly Ala Lys Arg Arg 
        675                 680                 685             


Glu Leu Ala Lys Met Ile Lys Ser Ile Ser Phe Glu Asp Phe Lys Asp 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Asn Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Asn Lys Tyr Ile Lys Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Asn Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2981
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2981

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Thr 
            20                  25                  30          


Pro Thr Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Lys Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asn Ser Ser Asn Ile Glu Leu Arg Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Lys Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Glu Ala Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Gly Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2982
<211>  954
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2982

Met Thr Lys Pro Glu Lys Lys Gln Ile Lys Gln Ala Thr Leu Thr Lys 
1               5                   10                  15      


Arg Met Gly Leu Lys Ser Thr Leu Val Phe Asp Asn Lys Ile Thr Val 
            20                  25                  30          


Thr Ser Phe Ala Asn Ser Ser Asn Ser Glu Lys Ala Ser Ala His Ile 
        35                  40                  45              


Glu Lys Arg Thr Asp Phe Trp Gly Lys Thr Ile Met Gln Asp Glu Lys 
    50                  55                  60                  


Met Phe Arg Thr Asp Val Glu Lys Gln Gln Ile Tyr Ile Glu Lys Glu 
65                  70                  75                  80  


Phe Pro Asp Glu Asn Asn Lys Ile Ile Thr Gln Thr Ala Met Phe Glu 
                85                  90                  95      


Asn Pro Ala Leu Arg Asn Cys Gly Lys Asp Tyr Ile Gly Met Lys Asn 
            100                 105                 110         


Ser Val Glu Lys Val Met Phe Gly Lys Glu Phe Pro Asn Asp Asn Leu 
        115                 120                 125             


His Ile Gln Ile Ala Tyr Asn Ile Leu Asp Ile Lys Lys Ile Ile Cys 
    130                 135                 140                 


Pro Tyr Ile Asn Asn Val Val Asn Ile Phe Tyr Asn Leu Gly Arg Gly 
145                 150                 155                 160 


Lys Leu Lys Asp Asp Lys Asn Asp Leu Leu Gly Asn Lys Ile Gly Leu 
                165                 170                 175     


Lys Ser Glu Glu Lys Ile Glu Asp Leu Leu Ile Asn Ser Ser Ala Tyr 
            180                 185                 190         


Phe Val Tyr Phe Gly Asp Val Phe Lys Gln Val Lys Leu Ser Lys Glu 
        195                 200                 205             


Gln Gln Glu Lys Ser Glu Glu Glu Lys Arg Arg Ile Trp Gln Glu Leu 
    210                 215                 220                 


Trp Asn Lys Asn Phe Asp His Asn Lys Asn Ile Val Asn Ser Leu Ile 
225                 230                 235                 240 


Lys Phe Arg Gln Met Cys Phe His Gln Asn Tyr Glu Asn Ser Asp Lys 
                245                 250                 255     


Glu Val Ser Ser Thr Ala Leu Phe Asn Ile Glu Gln Phe Leu Asn Lys 
            260                 265                 270         


Glu Glu Lys Ala Ser Leu Asp Glu Ile Tyr Thr Gly Ala Ile Asp Lys 
        275                 280                 285             


Val Asn Tyr Asp Phe Asn Lys Asn Ser Ser Asn Asn Leu Tyr Ile Leu 
    290                 295                 300                 


Glu Gln Ile Tyr Cys Asn Asp Lys Asn Leu Gly Gln Arg Tyr Tyr Asp 
305                 310                 315                 320 


Phe Val Val Lys Lys Ser Gln Cys Asn Leu Gly Leu Asp Thr Lys Leu 
                325                 330                 335     


Ile Arg Glu Leu Leu Ile Arg Lys Leu Ser Asp Glu Gly Leu Asp Ile 
            340                 345                 350         


Asn Asp Ser Arg Tyr Asp Thr Tyr Arg Asn Lys Ile Tyr Thr Val Phe 
        355                 360                 365             


Gly Phe Ile Leu Tyr Tyr Glu Leu Thr Lys Asn Glu Thr Phe Cys Gln 
    370                 375                 380                 


Glu Ile Val Ala Lys Leu Arg Arg Phe Gly Gly Asp Glu Ile Glu Lys 
385                 390                 395                 400 


Asn Lys Ile Tyr Asn Glu Tyr Phe Leu Arg Lys Glu Ala Val Tyr Asn 
                405                 410                 415     


Gln Ile Ala Glu Lys Phe Lys Gln Ser Val Cys Trp Phe Lys Lys Glu 
            420                 425                 430         


Lys Glu Lys Lys Lys Glu Phe Ser Ser Lys Thr Lys Ile Asp Leu Lys 
        435                 440                 445             


Ser Val Gln Lys Ile Glu Asp Gln Asn Ala Ser Val Phe Ala Lys Met 
    450                 455                 460                 


Val Tyr Leu Ile Ser Arg Phe Leu Asp Gly Lys Glu Ile Asn Glu Leu 
465                 470                 475                 480 


Cys Thr Lys Leu Leu Asn Lys Phe Lys Asn Ile Asn Glu Leu Val Glu 
                485                 490                 495     


Thr Ala Lys Arg Cys Gly Glu Thr Ile Glu Phe Cys Pro Glu Tyr Lys 
            500                 505                 510         


Met Phe Lys Asn Ser Ala Lys Leu Ala Glu Glu Met Arg Phe Val Gln 
        515                 520                 525             


Ser Val Ser Lys Met Lys Lys Leu Thr Lys Lys Glu Asp Lys Ser Ile 
    530                 535                 540                 


Lys Pro Gln Val Ile Asp Asp Ala Leu Glu Leu Leu Gly Leu Lys Ile 
545                 550                 555                 560 


Glu Lys Tyr Lys Lys Asp Asp Gln Gly Asn Phe Val Leu Asp Asp Gln 
                565                 570                 575     


Asn His Asn Val Trp Thr Asp Glu Tyr Lys Ser Tyr Arg Lys Glu Tyr 
            580                 585                 590         


Phe Thr Pro Lys Asn Ser Asp Ser Met Asn Asp Ala Glu Lys Ser Phe 
        595                 600                 605             


Val Ala Lys Gly His Gln Lys Arg Asn Phe Ile Ile Ser Asn Val Val 
    610                 615                 620                 


Leu Asn Lys Arg Phe Leu Tyr Val Ala Lys Tyr Gly Ser Pro Thr Ala 
625                 630                 635                 640 


Cys Asn Gln Met Met Lys Asn Gln Lys Ile Val Arg Met Ala Leu Glu 
                645                 650                 655     


Ser Ile Ser Glu Asp Gln Leu Arg Lys Tyr Ala Arg Arg Val Tyr Asp 
            660                 665                 670         


Asn Lys Glu His Phe Gln Asn Gln Thr Ala Asp Glu Ile Arg Glu Asn 
        675                 680                 685             


Leu Ala Lys Lys Leu Lys Asn Phe Asn Ile Gly Ala Glu Leu Lys Thr 
    690                 695                 700                 


Val Gly Asn Leu Ser Lys Lys Asp Phe Cys Ser Ser Lys Asn Thr Val 
705                 710                 715                 720 


Lys Asp Lys Ser Lys Ser Leu Ile Gly Leu Tyr Leu Thr Val Ala Tyr 
                725                 730                 735     


Leu Ile Thr Lys Asn Met Ile Lys Ile Asn Thr Arg Phe Ser Ile Ala 
            740                 745                 750         


Phe Gly Ala Tyr Glu Arg Asp Met Glu Phe Leu Leu Gln Gln Lys Lys 
        755                 760                 765             


Glu Lys Gly Asn Arg Phe Asp Trp Leu Ala Leu Thr Gln Lys Phe Leu 
    770                 775                 780                 


Ser Glu Asp Lys Asn Tyr Tyr Phe Glu His Asp Leu Arg Arg Lys Glu 
785                 790                 795                 800 


Ile Asn Lys Ile Ser Asp Arg Asp Glu Arg Lys Lys Gln His Arg Glu 
                805                 810                 815     


Asn Asp Lys Tyr Tyr Asp Ser Arg Met His Phe Ser Arg His Ser Phe 
            820                 825                 830         


Glu Tyr Ile Ser Lys Asn Phe Ala Glu Val Gln Ser His Pro Asp Pro 
        835                 840                 845             


Leu Lys Leu Phe Ile Lys Tyr Arg Asn Asn Val Met His Leu Asn Ile 
    850                 855                 860                 


Ile Arg Asp Leu Asn Asp Tyr Leu Pro Asp Phe Lys Arg Gly Lys Ala 
865                 870                 875                 880 


Phe Glu Lys Thr Asp Thr Phe Tyr Asp Leu Tyr Cys Tyr Cys Leu Gln 
                885                 890                 895     


Lys Met Leu Leu Ser Glu Val Asp Gly Phe Ser Ala Ile Asn Glu Asn 
            900                 905                 910         


Ile Asp Lys Tyr Cys Thr Ala Ser Lys Asp Phe Met Asn Leu Leu Asn 
        915                 920                 925             


Ile Ile Phe Ala Tyr Asn Val Pro Arg Tyr Lys Asn Leu Ser Asn Lys 
    930                 935                 940                 


Glu Leu Phe Tyr Arg Leu Asp Ser Glu Gln 
945                 950                 


<210>  2983
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2983

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Gln Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ser Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Lys Arg Pro Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asp Asp Lys Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  2984
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2984

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ile 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Glu Asp Ser Ser Asn Ile Glu Leu Gly Asp Val Asp Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Lys 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Met Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Ser Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr 
    850                 855                 860                 


Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  2985
<211>  954
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2985

Met Gly Lys Lys Ile His Ala Arg Asp Leu Arg Glu Gln Arg Lys Thr 
1               5                   10                  15      


Asp Arg Thr Val Lys Phe Ala Asp Gln Asn Glu Lys Arg Glu Ala Gln 
            20                  25                  30          


Arg Ala Val Gln Lys Lys Asp Ala Ala Val Ser Val Lys Ser Val Ser 
        35                  40                  45              


Ser Val Ser Ser Lys Lys Asp Asn Val Thr Lys Ser Met Ala Lys Ala 
    50                  55                  60                  


Ala Gly Val Lys Ser Val Phe Ala Val Glu Asn Thr Val Tyr Met Thr 
65                  70                  75                  80  


Ser Phe Gly Arg Gly Asn Asp Ala Val Leu Glu Gln Lys Ile Val Asp 
                85                  90                  95      


Thr Ser His Glu Pro Leu Asn Ile Asp Asp Pro Ala Tyr Gln Leu Asn 
            100                 105                 110         


Val Val Thr Met Asn Gly Tyr Ser Val Thr Gly His Arg Gly Glu Thr 
        115                 120                 125             


Val Ser Ala Val Thr Asp Asn Pro Leu Arg Arg Phe Asn Gly Gly Lys 
    130                 135                 140                 


Lys Asp Glu Pro Glu Gln Ser Val Pro Thr Asp Met Leu Cys Leu Lys 
145                 150                 155                 160 


Pro Thr Leu Glu Lys Lys Phe Phe Gly Lys Glu Phe Asn Asp Asn Ile 
                165                 170                 175     


His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala 
            180                 185                 190         


Val Tyr Ser Thr Asn Ala Ile Tyr Ala Leu Asn Asn Met Ser Ala Asp 
        195                 200                 205             


Glu Asn Ile Glu Asn Ser Asp Phe Phe Met Lys Arg Thr Thr Asp Glu 
    210                 215                 220                 


Thr Phe Asp Asp Phe Glu Lys Lys Lys Glu Ser Thr Asn Ser Arg Glu 
225                 230                 235                 240 


Lys Ala Asp Phe Asp Ala Phe Glu Lys Phe Ile Gly Asn Tyr Arg Leu 
                245                 250                 255     


Ala Tyr Phe Ala Asp Ala Phe Tyr Val Asn Lys Lys Asn Pro Lys Gly 
            260                 265                 270         


Lys Ala Arg Asn Val Leu Arg Glu Asp Lys Glu Leu Tyr Ser Val Leu 
        275                 280                 285             


Thr Leu Ile Gly Lys Leu Arg His Trp Cys Val His Ser Glu Asp Gly 
    290                 295                 300                 


Arg Ala Glu Phe Trp Leu Tyr Lys Leu Asn Glu Leu Lys Asp Asp Phe 
305                 310                 315                 320 


Lys Asn Val Leu Asp Val Val Tyr Asn Arg Pro Val Glu Glu Ile Asn 
                325                 330                 335     


Asn Arg Phe Ile Glu Asn Asn Lys Val Asn Ile Gln Ile Leu Gly Ser 
            340                 345                 350         


Val Tyr Lys Asn Thr Asp Ile Ala Glu Leu Val Arg Ser Tyr Tyr Glu 
        355                 360                 365             


Phe Leu Ile Thr Lys Lys Tyr Lys Asn Met Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Ser Met Phe Glu Gly Lys Gly Tyr Ala Asp Lys Glu Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Asn Lys Leu Tyr Gln Met Thr Asp Phe Ile Leu Tyr 
                405                 410                 415     


Thr Gly Tyr Ile Asn Glu Asp Ser Asp Arg Ala Asp Asp Leu Val Asn 
            420                 425                 430         


Thr Leu Arg Ser Ser Leu Lys Glu Asp Asp Lys Thr Thr Val Tyr Cys 
        435                 440                 445             


Lys Glu Ala Asp Tyr Leu Trp Lys Lys Tyr Arg Glu Ser Ile Arg Glu 
    450                 455                 460                 


Val Ala Asp Ala Leu Asp Gly Asp Asn Ile Lys Lys Leu Ser Lys Ser 
465                 470                 475                 480 


Asn Ile Glu Ile Gln Glu Asp Lys Leu Arg Lys Cys Phe Ile Ser Tyr 
                485                 490                 495     


Ala Asp Ser Val Ser Glu Phe Thr Lys Leu Ile Tyr Leu Leu Thr Arg 
            500                 505                 510         


Phe Leu Ser Gly Lys Glu Ile Asn Asp Leu Val Thr Thr Leu Ile Asn 
        515                 520                 525             


Lys Phe Asp Asn Ile Arg Ser Phe Leu Glu Ile Met Asp Glu Leu Gly 
    530                 535                 540                 


Leu Asp Arg Thr Phe Thr Ala Glu Tyr Ser Phe Phe Glu Gly Ser Thr 
545                 550                 555                 560 


Lys Tyr Leu Ala Glu Leu Ile Glu Leu Asn Ser Phe Val Lys Ser Cys 
                565                 570                 575     


Ser Phe Asp Ile Asn Ala Lys Arg Thr Met Tyr Arg Asp Ala Leu Asp 
            580                 585                 590         


Ile Leu Gly Ile Glu Ser Gly Lys Thr Glu Glu Asp Ile Glu Lys Met 
        595                 600                 605             


Ile Asp Asn Ile Leu Gln Ile Asp Ala Asn Gly Asp Lys Lys Leu Lys 
    610                 615                 620                 


Lys Asn Asn Gly Leu Arg Asn Phe Ile Ala Ser Asn Val Ile Asp Ser 
625                 630                 635                 640 


Asn Arg Phe Lys Tyr Leu Val Arg Tyr Gly Asn Pro Lys Lys Ile Arg 
                645                 650                 655     


Glu Thr Ala Lys Cys Glu Pro Ala Val Arg Phe Val Leu Asn Glu Ile 
            660                 665                 670         


Pro Asp Ala Gln Ile Glu Arg Tyr Tyr Glu Ala Cys Cys Pro Lys Asn 
        675                 680                 685             


Thr Ala Leu Cys Ser Ala Asn Lys Arg Arg Glu Lys Leu Ala Asp Met 
    690                 695                 700                 


Ile Ala Glu Ile Glu Phe Glu Asn Phe Ser Asp Ala Gly Asn Tyr Gln 
705                 710                 715                 720 


Lys Ala Asn Val Thr Ser Arg Thr His Glu Ala Glu Ile Lys Arg Lys 
                725                 730                 735     


Asn Gln Ala Ile Ile Arg Leu Tyr Leu Thr Val Met Tyr Ile Met Leu 
            740                 745                 750         


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Phe His Cys 
        755                 760                 765             


Val Glu Arg Asp Thr Lys Leu Tyr Ala Glu Ser Gly Leu Glu Val Gly 
    770                 775                 780                 


Asn Ile Glu Lys Asn Lys Thr Asn Leu Thr Met Ala Val Met Gly Val 
785                 790                 795                 800 


Lys Leu Glu Asn Gly Ile Ile Lys Thr Glu Phe Asp Lys Ser Leu Ala 
                805                 810                 815     


Glu Asn Ala Ala Asn Arg Tyr Leu Arg Asn Ala Arg Trp Tyr Lys Leu 
            820                 825                 830         


Ile Leu Asp Asn Leu Lys Lys Ser Glu Arg Ala Val Val Asn Glu Phe 
        835                 840                 845             


Arg Asn Thr Val Cys His Leu Asn Ala Ile Arg Asn Ile Asn Ile Asn 
    850                 855                 860                 


Ile Lys Glu Ile Lys Glu Val Glu Asn Tyr Phe Ala Leu Tyr His Tyr 
865                 870                 875                 880 


Leu Ile Gln Lys His Leu Glu Asn Arg Phe Ala Asp Lys Lys Val Glu 
                885                 890                 895     


Arg Asp Thr Gly Asp Phe Ile Ser Lys Leu Glu Glu His Lys Thr Tyr 
            900                 905                 910         


Cys Lys Asp Phe Val Lys Ala Tyr Cys Thr Pro Phe Gly Tyr Asn Leu 
        915                 920                 925             


Val Arg Tyr Lys Asn Leu Thr Ile Asp Gly Leu Phe Asp Lys Asn Tyr 
    930                 935                 940                 


Pro Gly Lys Asp Asp Ser Asp Glu Gln Lys 
945                 950                 


<210>  2986
<211>  961
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2986

Met Ala Lys Lys Lys Thr Ala Lys Gln Ile Arg Glu Glu Gln Lys Ala 
1               5                   10                  15      


Ala Lys Met Gln Lys Ile Gln Ala Phe Val Lys Ala Lys Glu Ala Lys 
            20                  25                  30          


Lys Glu Thr Glu Lys Thr Ala Ser Ala Val Lys Ile Pro Val Lys Lys 
        35                  40                  45              


Asn Arg Lys Lys Ser Leu Ala Lys Ala Ser Gly Ser Lys Ala Val Leu 
    50                  55                  60                  


Ile Val Gly Asn Asp Ile Ile Met Thr Ser Tyr Gly Glu Arg Cys Leu 
65                  70                  75                  80  


Ala Asn Leu Glu His Lys Ile Thr Pro Glu Leu Asn Thr Glu Ser Leu 
                85                  90                  95      


Thr Val Asn Asn Ala Leu Asn Asp Val Asn Ala Lys Asp Gly Lys Asn 
            100                 105                 110         


Ile Ser Phe Thr Gly Arg Ile Ser Gly Leu Ser Val Ser Ser Asp Asn 
        115                 120                 125             


Pro Leu His Phe His Gln Thr Glu Glu Arg Lys Ala Pro Lys Pro Gly 
    130                 135                 140                 


Thr Asp Leu Leu Cys Leu Lys Asp Lys Leu Glu Gln Trp Tyr Phe Asp 
145                 150                 155                 160 


Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Gln Ile Gln 
                165                 170                 175     


Asp Ile Glu Lys Ile Leu Ala Ser His Val Asn Asn Ile Val Phe Ala 
            180                 185                 190         


Leu Asp Asn Ile Leu His Ala Thr Glu Ser Glu Thr Gly Asp Phe Leu 
        195                 200                 205             


Gly Met Gly Tyr Met Arg Ala Thr Asn Thr Phe Glu Glu Tyr Arg Asp 
    210                 215                 220                 


Ser Ala Ile Ser Asn Val Lys Lys Ser Tyr Glu Thr Phe Glu Thr Tyr 
225                 230                 235                 240 


Ile Lys Lys Lys Glu Leu Leu Tyr Phe Gly Glu Ala Phe Tyr His Gly 
                245                 250                 255     


Asn Thr Cys Arg Lys Pro Glu Asp Ile Tyr His Ile Leu Ala Met Val 
            260                 265                 270         


Ser Ser Leu Arg Gln Phe Cys Phe His Ser Thr Phe Asp Asp Lys Ser 
        275                 280                 285             


Lys Ser Ile Lys Gly Ser Trp Leu Tyr Gln Leu Asp Glu Gln Leu Ser 
    290                 295                 300                 


Asp Glu Phe Lys Glu Thr Leu Gly Met Leu Trp Ala Glu Ala Thr Glu 
305                 310                 315                 320 


Lys Leu Asp Arg Asp Phe Leu Lys Thr Asn Thr Val Asn Leu His Ile 
                325                 330                 335     


Leu Cys Glu Ile Phe Asp Lys Glu Lys Gln Glu Asp Ile Ile Asn Ala 
            340                 345                 350         


Tyr Tyr Glu Phe Leu Met Lys Lys Ser Phe Lys Asn Leu Gly Phe Ser 
        355                 360                 365             


Val Lys Lys Leu Arg Glu Cys Met Leu Glu Glu Ala Glu Leu Asn Glu 
    370                 375                 380                 


Phe Lys Glu Asp Lys Tyr Asn Ser Val Arg Ser Lys Leu Tyr Lys Leu 
385                 390                 395                 400 


Phe Asp Phe Ile Leu Val His His Tyr Lys Asn Asp Ser Ser Pro Glu 
                405                 410                 415     


Ser Thr Ala Leu Lys Asn Leu Leu Arg Thr Cys Leu Thr Asp Glu Glu 
            420                 425                 430         


Lys Glu Lys Val Tyr Val Gln Thr Ala Lys Glu Leu Thr Ala Leu Tyr 
        435                 440                 445             


Ser Tyr His Phe Lys Glu Ala Ser Val Ser Val Asn Ala Arg Asn Ile 
    450                 455                 460                 


Lys Glu Tyr Gln Glu Lys Ala Gln Val Tyr His Ile Ser Ile Ala Asp 
465                 470                 475                 480 


Lys Ile Ser Ser Thr Gly Ile Gly Leu Phe Ser Gln Leu Ile Tyr Met 
                485                 490                 495     


Leu Thr Leu Leu Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr 
            500                 505                 510         


Leu Ile Asn Lys Phe Asp Asn Ile Ile Gly Phe Leu Asp Ile Leu Asp 
        515                 520                 525             


Lys Met His Leu Asp Thr Glu Phe Lys Lys Glu Tyr Gln Phe Phe Asn 
    530                 535                 540                 


Gln Glu Asn Cys Glu Tyr Thr Ala Lys Glu Leu Arg Thr Ile Asn Ser 
545                 550                 555                 560 


Leu Ala Arg Met Gln Lys Pro Ser Ala Asn Ala Lys Lys Val Met Phe 
                565                 570                 575     


Arg Asp Ala Leu Arg Ile Leu Gly Met Asp Asn Arg Ser Asp Glu Glu 
            580                 585                 590         


Ile Asp Lys Glu Leu Asp Arg Thr Met Pro Val Gly Ala Asp Gly Lys 
        595                 600                 605             


Phe Ile Lys Gly Lys Gln Gly Phe Arg Asn Phe Ile Ala Ser Asn Val 
    610                 615                 620                 


Ile Glu Ser Ser Arg Phe Arg Tyr Leu Val Arg Tyr Asn Asn Pro His 
625                 630                 635                 640 


Lys Thr Arg Thr Leu Val Gln Asn Arg Asn Val Val Lys Phe Val Leu 
                645                 650                 655     


Glu Gly Ile Pro Asp Thr Gln Ile Lys Arg Tyr Phe Asp Val Cys Lys 
            660                 665                 670         


Asp Lys Asp Thr Pro Asp Thr Ser Ser Lys Ser Ala Gln Ile Asp Val 
        675                 680                 685             


Leu Ala Gly Ile Leu Thr Asn Ile Asp Tyr Lys Ile Phe Glu Asp Val 
    690                 695                 700                 


Pro Gln Ser Ala Lys Ile Asn Lys Asp Asp Ala Ser Arg Asn Arg Ala 
705                 710                 715                 720 


Asp Ala Leu Lys Lys Gln Arg Tyr Gln Ala Ile Val Thr Leu Tyr Leu 
                725                 730                 735     


Thr Val Leu Tyr Leu Val Thr Lys Asn Leu Val Tyr Val Asn Ser Arg 
            740                 745                 750         


Tyr Val Met Ala Phe His Cys Leu Glu Arg Asp Ala Leu Leu Tyr Gly 
        755                 760                 765             


Val Ala Phe Pro Pro Val Glu Lys Lys Trp Gly Lys Asp Tyr Ser Gln 
    770                 775                 780                 


Leu Thr Ala Ser Leu Leu Lys Asp Glu Thr Tyr Thr Thr Tyr Gly His 
785                 790                 795                 800 


Leu Lys Asn Gln Lys Gly His Arg Lys Trp His Val Leu Val Ser Arg 
                805                 810                 815     


Asn Leu Glu Asn Ser Asp Lys Lys Ala Val His Trp Phe Arg Asn Ile 
            820                 825                 830         


Ser Ala His Ile Ser Val Ile Arg Asn Ile Asn Glu Tyr Ile Gly Glu 
        835                 840                 845             


Val Gln Glu Phe His Ser Tyr Phe Glu Leu Tyr His Tyr Leu Val Gln 
    850                 855                 860                 


Lys Met Ile Ala Lys Asn Asn Trp Tyr Asp Ala Lys Ser Gln Pro Lys 
865                 870                 875                 880 


Thr Ala Glu Tyr Leu Glu Asn Leu Glu Lys Tyr His Thr Tyr Ser Lys 
                885                 890                 895     


Asp Phe Val Lys Ala Tyr Cys Ile Pro Phe Gly Tyr Val Val Pro Arg 
            900                 905                 910         


Tyr Lys Asn Leu Thr Ile Asn Glu Leu Phe Asp Arg Asn Asn Pro Leu 
        915                 920                 925             


Pro Glu Pro Lys Lys Asp Lys Glu Lys Lys Asp Lys Lys Asn Lys Lys 
    930                 935                 940                 


Asn Lys Lys Lys Arg Asn Glu Glu Val Asp Glu Ile Asn Glu Asn Ser 
945                 950                 955                 960 


Lys 
    


<210>  2987
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2987

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Gln Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Asp Glu Ser 
        195                 200                 205             


His Asp Asp Phe Met Gly Tyr Leu Ser Ala Gln Asn Thr Tyr Tyr Ile 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val 
            260                 265                 270         


Ser Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu 
    290                 295                 300                 


Tyr Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Val Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Val Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Trp Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asp Asp Lys Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  2988
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2988

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asp Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Gly Asp Glu Ser His Asp Asp 
        195                 200                 205             


Ile Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe Thr Asp 
    210                 215                 220                 


Pro Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Ala Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu Tyr Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Ile Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Met Gly Ala Lys Arg Arg 
        675                 680                 685             


Glu Leu Ala Lys Met Ile Lys Ser Ile Ser Phe Glu Asp Phe Lys Asp 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Asn Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Asn Lys Tyr Ile Lys Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Asn Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2989
<211>  954
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2989

Met Gly Lys Lys Ile His Ala Arg Asp Leu Arg Glu Gln Arg Lys Thr 
1               5                   10                  15      


Asp Arg Thr Glu Lys Phe Ala Asp Gln Asn Lys Lys Arg Glu Ala Glu 
            20                  25                  30          


Arg Ala Val Gln Lys Lys Asp Ala Ala Val Ser Val Lys Ser Val Ser 
        35                  40                  45              


Ser Val Ser Ser Lys Lys Asp Asn Ala Thr Lys Ser Met Ala Lys Ala 
    50                  55                  60                  


Ala Gly Val Lys Ser Val Phe Ala Val Gly Asn Thr Val Tyr Met Thr 
65                  70                  75                  80  


Ser Phe Gly Arg Gly Asn Asp Ala Val Leu Glu Gln Lys Ile Val Asp 
                85                  90                  95      


Thr Ser His Glu Pro Leu Asn Ile Asp Asp Pro Ala Tyr Gln Leu Asn 
            100                 105                 110         


Val Val Thr Met Asn Gly Tyr Ser Val Thr Gly His Arg Gly Glu Thr 
        115                 120                 125             


Val Ser Ala Val Thr Asp Asn Pro Leu Arg Arg Phe Asn Gly Gly Lys 
    130                 135                 140                 


Lys Asp Glu Pro Glu Gln Ser Val Pro Thr Asp Met Leu Cys Leu Lys 
145                 150                 155                 160 


Pro Thr Leu Glu Lys Lys Phe Phe Gly Lys Glu Phe Asp Asp Asn Ile 
                165                 170                 175     


His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala 
            180                 185                 190         


Val Tyr Ser Thr Asn Ala Ile Tyr Ala Leu Asn Asn Met Ser Ala Asp 
        195                 200                 205             


Glu Asn Ile Glu Asn Ser Asp Phe Phe Met Lys Arg Thr Thr Asp Glu 
    210                 215                 220                 


Thr Phe Asp Asp Phe Glu Lys Lys Lys Glu Ser Thr Asn Ser Arg Glu 
225                 230                 235                 240 


Lys Ala Asp Phe Asp Ala Phe Glu Lys Phe Ile Ala Asn Tyr Arg Leu 
                245                 250                 255     


Ala Tyr Phe Ala Asp Ala Phe Tyr Val Asn Lys Lys Asn Pro Lys Gly 
            260                 265                 270         


Lys Ala Arg Asn Val Leu Arg Glu Asp Lys Glu Leu Tyr Ser Val Leu 
        275                 280                 285             


Thr Leu Ile Gly Lys Leu Arg His Trp Cys Val His Ser Glu Glu Gly 
    290                 295                 300                 


Arg Ala Glu Phe Trp Leu Tyr Lys Leu Asp Glu Leu Lys Asp Asp Phe 
305                 310                 315                 320 


Lys Asn Val Leu Asp Val Val Tyr Asn Arg Pro Val Glu Glu Ile Asn 
                325                 330                 335     


Asn Arg Phe Ile Glu Asn Asn Lys Val Asn Ile Gln Ile Leu Gly Ser 
            340                 345                 350         


Val Tyr Lys Asn Thr Asp Ile Ala Glu Leu Val Arg Ser Tyr Tyr Glu 
        355                 360                 365             


Phe Leu Ile Thr Lys Lys Tyr Lys Asn Met Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Ser Met Leu Glu Gly Lys Gly Tyr Ala Asp Lys Glu Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Asn Lys Leu Tyr Gln Met Thr Asp Phe Ile Leu Tyr 
                405                 410                 415     


Thr Gly Tyr Ile Asn Glu Asp Ser Asp Arg Ala Asp Asp Leu Val Asn 
            420                 425                 430         


Thr Leu Arg Ser Ser Leu Lys Glu Asp Asp Lys Thr Thr Val Tyr Cys 
        435                 440                 445             


Lys Glu Ala Asp Tyr Leu Trp Lys Lys Tyr Cys Glu Ser Ile Arg Glu 
    450                 455                 460                 


Val Ala Glu Ala Leu Asp Gly Asp Asn Ile Lys Arg Leu Ser Lys Ser 
465                 470                 475                 480 


Asn Ile Glu Ile Arg Asp Asn Glu Leu Arg Lys Cys Phe Ile Ser Tyr 
                485                 490                 495     


Ala Asp Ser Val Ser Glu Phe Thr Lys Leu Ile Tyr Leu Leu Thr Arg 
            500                 505                 510         


Phe Leu Ser Gly Lys Glu Ile Asn Asp Leu Val Thr Thr Leu Ile Asn 
        515                 520                 525             


Lys Phe Asp Asn Ile Arg Ser Phe Leu Glu Ile Met Asp Glu Leu Gly 
    530                 535                 540                 


Leu Asp Arg Thr Phe Thr Ala Glu Tyr Ser Phe Phe Glu Asp Ser Thr 
545                 550                 555                 560 


Lys Tyr Leu Ala Glu Leu Val Glu Leu Asn Ser Phe Val Lys Ser Cys 
                565                 570                 575     


Ser Phe Asp Ile Asn Ala Lys Arg Thr Met Tyr Arg Asp Ala Leu Asp 
            580                 585                 590         


Ile Leu Gly Ile Lys Ser Gly Lys Thr Glu Glu Asp Ile Glu Lys Met 
        595                 600                 605             


Ile Asp Asn Ile Leu Gln Ile Asp Ala Asn Gly Asp Lys Lys Leu Lys 
    610                 615                 620                 


Lys Asn Asn Gly Leu Arg Asn Phe Ile Ala Ser Asn Val Ile Asp Ser 
625                 630                 635                 640 


Asn Arg Phe Lys Tyr Leu Val Arg Tyr Gly Asn Pro Lys Lys Ile Arg 
                645                 650                 655     


Glu Thr Ala Lys Cys Lys Pro Ala Val Arg Phe Val Leu Asn Glu Ile 
            660                 665                 670         


Pro Asp Ala Gln Ile Glu Arg Tyr Tyr Glu Ala Cys Cys Pro Lys Asn 
        675                 680                 685             


Thr Ala Leu Cys Ser Ala Asn Lys Arg Arg Glu Lys Leu Ala Asp Met 
    690                 695                 700                 


Ile Ala Glu Ile Lys Phe Glu Asn Phe Ser Asp Ala Gly Asn Tyr Gln 
705                 710                 715                 720 


Lys Ala Asn Val Thr Ser Lys Thr His Glu Ala Glu Ile Lys Arg Lys 
                725                 730                 735     


Asn Gln Ala Ile Ile Arg Leu Tyr Leu Thr Val Met Tyr Ile Met Leu 
            740                 745                 750         


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Phe His Cys 
        755                 760                 765             


Val Glu Arg Asp Thr Lys Leu Tyr Ala Glu Ser Gly Leu Glu Val Gly 
    770                 775                 780                 


Asn Ile Glu Lys Asn Lys Thr Asn Leu Thr Met Ala Val Met Gly Val 
785                 790                 795                 800 


Lys Leu Glu Asn Gly Ile Ile Lys Thr Glu Phe Asp Lys Ser Leu Ala 
                805                 810                 815     


Glu Asn Ala Ala Asn Arg Tyr Leu Arg Asn Ala Arg Trp Tyr Lys Leu 
            820                 825                 830         


Ile Leu Asp Asn Leu Lys Lys Ser Glu Arg Ala Val Val Thr Asp Phe 
        835                 840                 845             


Arg Asn Thr Val Cys His Leu Asn Ala Ile Arg Asn Ile Asn Ile Asn 
    850                 855                 860                 


Ile Asp Gly Ile Lys Glu Val Glu Asn Tyr Phe Ala Leu Tyr His Tyr 
865                 870                 875                 880 


Leu Ile Gln Lys His Leu Glu Asn Arg Phe Ala Asp Lys Lys Val Glu 
                885                 890                 895     


Arg Asp Thr Gly Asp Phe Ile Ser Lys Leu Glu Glu His Lys Thr Tyr 
            900                 905                 910         


Cys Lys Asp Phe Val Lys Ala Tyr Cys Thr Pro Phe Gly Tyr Asn Leu 
        915                 920                 925             


Val Arg Tyr Lys Asn Leu Thr Ile Asp Gly Leu Phe Asp Lys Asn Tyr 
    930                 935                 940                 


Pro Gly Lys Asp Asp Ser Asp Glu Gln Lys 
945                 950                 


<210>  2990
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2990

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Ile Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Ile Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Asn Arg Val Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu His Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Ile Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Glu 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ser Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Lys Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Arg Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  2991
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2991

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asn Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Asp Asp Asp Glu Ser His Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe Thr Asp 
    210                 215                 220                 


Pro Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Asn Ala Leu Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Glu 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Lys Val Ala Glu Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Cys Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Arg Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2992
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2992

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asp Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Phe Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Lys Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Ala Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Leu Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr Tyr Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Leu Ser Glu His Ser Glu Tyr Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Asn Ser Lys Lys Val Tyr Arg Glu Cys Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ala Lys Leu Trp Val Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Val 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2993
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2993

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Gln Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ser Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ser Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Lys Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Arg Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2994
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2994

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Gln Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ser Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ser Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Lys Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Arg Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  2995
<211>  946
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2995

Met Lys Lys Phe Ser Asn Ile Lys Arg Leu Gly Val Lys Ser Val His 
1               5                   10                  15      


Tyr Ala Asn Asn Thr Val Ile Val Glu Asp His Phe Ser Lys Asn Thr 
            20                  25                  30          


Asn Ile Leu Phe Thr Ala Glu Tyr Glu Asn Ile Asp Asp Leu Lys Ser 
        35                  40                  45              


Cys Thr Asn Ile Asp Lys Thr Ala Glu Asn Lys Gly Val Arg Phe Thr 
    50                  55                  60                  


Asp Leu Lys Asn Lys Asn Gly Phe Glu Leu Ser Ala Met Ala Gln Lys 
65                  70                  75                  80  


Gln Ile Leu Lys Ser Arg Val Asn Arg Val Lys Lys Val Ser Tyr Thr 
                85                  90                  95      


Gln Glu Leu Phe Asp Ile Thr Thr Asp Asn Asn Ile Glu Val Gln Ile 
            100                 105                 110         


Phe Ser Asn Leu Glu Asp Val Lys Lys Val Ile Ala Pro Tyr Tyr Asn 
        115                 120                 125             


Asn Val Ala Tyr Ala Ile Asn Ser Leu Tyr Arg Asp Ile Ser Asn Asp 
    130                 135                 140                 


Asp Ser Tyr Gly Phe Asp Lys Ile Gly Ser Ile Pro Val Asp Ala Asp 
145                 150                 155                 160 


Trp Tyr Asn Phe Leu Lys Asp Ala Pro Asp Lys Lys Glu Lys Trp Thr 
                165                 170                 175     


Thr Tyr Ile Ile Pro Ser Tyr Lys Lys Val Ile Ala Arg Phe Gly Ile 
            180                 185                 190         


Gln Met Glu Lys Asn Gln Gln Val Asn Phe Cys Lys Cys Leu Glu Tyr 
        195                 200                 205             


Val Ala Ile Arg Asn Gly Leu Phe Val Lys Phe Lys Asp Glu Lys Val 
    210                 215                 220                 


Asp Pro Asp Lys Leu Leu Asn Lys Lys Ile Gln Glu Lys Leu Asp Lys 
225                 230                 235                 240 


Leu Ile Ser Asp Lys Glu Val Asn Asp Lys Leu Phe Glu Leu Ala Lys 
                245                 250                 255     


Thr Pro Val Ser Glu Phe Cys Ala Glu Ala Asn Ala Ile Pro Leu Tyr 
            260                 265                 270         


Arg Tyr Ala Phe Ile Gly Gln Lys Gly Lys Arg Ile Glu Lys Ile Val 
        275                 280                 285             


Leu Asp Lys Leu Glu Glu Asn Glu Ile Leu Ser Ser Leu Val Arg Lys 
    290                 295                 300                 


Ile Asp Glu Asn Glu Thr Thr Tyr Asn Tyr Leu Arg Leu Leu Ser Ala 
305                 310                 315                 320 


Ile Arg Gln Tyr Val Val His Asn Ser Arg Lys Val Arg Ile Asp Lys 
                325                 330                 335     


Asn Val Phe Ile Asn Asp Thr Ala Lys Arg Asp Val Glu Glu Phe Ala 
            340                 345                 350         


Lys Gln Phe Gln Lys Asn Asn Tyr Lys Tyr Phe Cys Ile Leu Lys Glu 
        355                 360                 365             


Leu Tyr Ser Asp Ser Asp Ile Leu Glu Gln Phe Phe Asp Tyr Thr Val 
    370                 375                 380                 


Phe Asp Glu Ala Arg Asn Leu Lys Ile Ser Ile Asp Lys Ile Lys Lys 
385                 390                 395                 400 


Gly Ile Thr Ala Asn Ile Asp Ile Ser Ala Asp Val Glu Pro Asp Lys 
                405                 410                 415     


Leu Ser Glu Tyr Ala Asn Lys Phe Arg Thr Val Thr Met Phe Ala Leu 
            420                 425                 430         


Thr Lys Tyr Leu Lys Glu Asn Val Gly Glu Ile Glu Asp Phe Leu Ala 
        435                 440                 445             


Asn Ile Lys Val Cys Ser Ser Asp Glu Glu Lys Ala Gly Val Tyr Glu 
    450                 455                 460                 


Gln Lys Ala Lys Glu Phe Ile Thr Lys Phe Asp Ser Phe Lys Asp Ile 
465                 470                 475                 480 


Arg Ser Val Val Lys Lys His Leu Gly Thr Gln Lys Val Asn Glu Lys 
                485                 490                 495     


Phe Asp Phe Tyr Pro Ser Asp Ile Asn Phe Gly Arg Asp Ser Asn Val 
            500                 505                 510         


Phe Phe Asn Met Leu Tyr Val Met Ser Lys Phe Leu Thr Val Asn Glu 
        515                 520                 525             


Ala Arg Ile Met Phe Gln Lys Ile Lys Ser Lys Tyr Asp Ser Val Lys 
    530                 535                 540                 


Ser Leu Leu Lys Ile Ala Glu Leu Thr Gly Val Thr Leu Ser Asp Asn 
545                 550                 555                 560 


Leu Phe Asp Arg Phe Arg Met Ile Phe Asp Lys Glu Arg Val Asp Glu 
                565                 570                 575     


Tyr Gln Lys Gln Leu Ile Val Leu Gln Ser Ile Arg Thr Arg Asn Gly 
            580                 585                 590         


Val Ser Gln Glu Gly Phe Ala Lys Glu Leu Lys Arg Ile Phe Asp Met 
        595                 600                 605             


Phe Lys Lys Asp Asp Ile Ser Tyr Glu Glu Phe Glu Lys Glu Leu Ser 
    610                 615                 620                 


Leu Asp Glu Asn Gln Asn Glu Ile Lys Asn Lys Ser Phe Lys Leu Lys 
625                 630                 635                 640 


Pro Leu Lys Ser Tyr Leu Arg Asn Asp Val Tyr Lys Ser Lys Gln Tyr 
                645                 650                 655     


Gln Tyr Ile Ser Ser Phe Ala Ser Ala Gly Ile Cys Gln Lys Ile Met 
            660                 665                 670         


Glu Asn Lys Asp Ile Val Ala Phe Val Leu Asn Gly Met Leu Tyr Gln 
        675                 680                 685             


Glu Gly Lys Leu Ser Met Pro Met His Lys Tyr Val Ala Lys Val Tyr 
    690                 695                 700                 


His Asp Phe Arg Arg Glu Lys Ile Asp Glu Asn Ser Ala Asn Tyr Leu 
705                 710                 715                 720 


Leu Asp Gln Asn Gln Ile Ser Ser Leu Val Asn Ser Leu Cys Asp Leu 
                725                 730                 735     


Lys Leu Glu Asn Ile Ile Glu Ala Ile Phe Lys Glu Ser Arg Val Asn 
            740                 745                 750         


Tyr Lys Ala Leu Val Arg Leu Tyr Leu Asn Ile Cys Tyr Leu Phe Val 
        755                 760                 765             


Lys Asn Ile Ile Ser Leu Asn Ser Thr Tyr Leu Ile Gln Phe Gln Asp 
    770                 775                 780                 


Tyr Glu Asn Ile Tyr Lys Gln Leu His Leu Glu Asp Leu Met Asp Ile 
785                 790                 795                 800 


Thr Tyr Asp Phe Gly Val Leu Asn Asn Phe Val Glu Asn Ala Pro Asn 
                805                 810                 815     


Lys Lys Cys Arg Ser Tyr Met Gln Leu Gln Thr Leu Leu Glu Lys Asp 
            820                 825                 830         


Tyr Ile Lys Asp Tyr Ile Tyr Thr Pro Glu Tyr Gln Val Leu Gln Asp 
        835                 840                 845             


Arg Tyr Arg Asn Leu Val Val His Ser Ser Leu Leu Phe Gly Leu Asp 
    850                 855                 860                 


Lys Ile Asp Phe Asp Phe Gly Glu Val Gln Asn Ile Ser Ser Tyr Phe 
865                 870                 875                 880 


Ala Ile Tyr Gln Thr Leu Val Gln Arg Leu Val Glu Gln Asp Ala Arg 
                885                 890                 895     


Glu Val Trp Gly Glu Lys Phe Asp Glu Tyr Phe Ala Leu Asn Asn Gly 
            900                 905                 910         


Lys Thr Tyr Ser Thr Lys Leu Cys Ile Ala Leu Asn Met Pro Tyr Ala 
        915                 920                 925             


Tyr Asn Ile Ser Arg Phe Asn Asn Asn Thr Ile Glu Lys Tyr Ser Asn 
    930                 935                 940                 


Lys Arg 
945     


<210>  2996
<211>  952
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2996

Met Gly Lys Lys Ile His Ala Arg Asp Leu Arg Glu Gln Arg Lys Thr 
1               5                   10                  15      


Asp Arg Thr Glu Lys Phe Ala Asp Gln Asn Lys Lys Arg Glu Ala Glu 
            20                  25                  30          


Arg Ala Val Gln Lys Lys Asp Ala Ala Val Ser Val Lys Ser Val Ser 
        35                  40                  45              


Ser Val Ser Ser Lys Lys Asp Asn Val Thr Lys Ser Met Ala Lys Ala 
    50                  55                  60                  


Ala Gly Val Lys Ser Val Phe Ala Val Gly Asn Thr Val Tyr Met Thr 
65                  70                  75                  80  


Ser Phe Gly Arg Gly Asn Asp Ala Val Leu Glu Gln Lys Ile Val Asp 
                85                  90                  95      


Thr Ser His Glu Gln Leu Asn Ile Asp Asp Pro Ala Tyr Gln Leu Asn 
            100                 105                 110         


Val Val Thr Met Asn Gly Tyr Ser Val Thr Gly His Arg Gly Glu Thr 
        115                 120                 125             


Val Ser Ala Val Thr Asp Asn Pro Leu Arg Arg Phe Asn Gly Gly Lys 
    130                 135                 140                 


Lys Asp Glu Pro Glu Gln Ser Val Pro Thr Asp Met Leu Cys Leu Lys 
145                 150                 155                 160 


Pro Thr Leu Glu Lys Lys Phe Phe Gly Lys Glu Phe Asn Asp Asn Ile 
                165                 170                 175     


His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala 
            180                 185                 190         


Val Tyr Ser Thr Asn Ala Ile Tyr Ala Leu Asn Asn Met Ser Ala Asp 
        195                 200                 205             


Glu Asn Ile Glu Asn Ser Asp Phe Phe Met Lys Arg Thr Thr Asp Glu 
    210                 215                 220                 


Thr Phe Asp Asp Phe Glu Lys Lys Lys Glu Ser Thr Asn Ser Arg Glu 
225                 230                 235                 240 


Lys Ala Asp Phe Asp Ala Phe Glu Lys Phe Ile Gly Asn Tyr Arg Leu 
                245                 250                 255     


Ala Tyr Phe Ala Asp Ala Phe Tyr Val Asn Lys Lys Asn Pro Lys Gly 
            260                 265                 270         


Lys Ala Lys Asn Val Leu Arg Glu Asp Lys Glu Leu Tyr Ser Val Leu 
        275                 280                 285             


Thr Leu Ile Gly Lys Leu Arg His Trp Cys Val His Ser Glu Glu Gly 
    290                 295                 300                 


Arg Ala Glu Phe Trp Leu Tyr Lys Leu Asn Glu Leu Lys Asp Asp Phe 
305                 310                 315                 320 


Lys Asn Val Leu Asp Val Val Tyr Asn Arg Pro Val Glu Glu Ile Asn 
                325                 330                 335     


Asn Arg Phe Ile Glu Asn Asn Lys Val Asn Ile Gln Ile Leu Gly Ser 
            340                 345                 350         


Val Tyr Lys Asn Thr Asp Ile Ala Glu Leu Val Arg Ser Tyr Tyr Glu 
        355                 360                 365             


Phe Leu Ile Thr Lys Lys Tyr Lys Asn Met Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Ser Met Leu Glu Gly Lys Gly Tyr Ala Asp Lys Glu Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Asn Lys Leu Tyr Gln Met Thr Asp Phe Ile Leu Tyr 
                405                 410                 415     


Thr Gly Tyr Ile Asn Glu Asp Ser Asp Arg Ala Asp Asp Leu Val Asn 
            420                 425                 430         


Thr Leu Arg Ser Ser Leu Lys Glu Asp Asp Lys Thr Thr Val Tyr Cys 
        435                 440                 445             


Lys Glu Ala Asp Tyr Leu Trp Lys Lys Tyr Arg Glu Ser Ile Arg Glu 
    450                 455                 460                 


Val Ala Asp Ala Leu Asp Gly Asp Asn Ile Lys Arg Leu Ser Lys Ser 
465                 470                 475                 480 


Asn Ile Glu Ile Gln Glu Asp Lys Leu Arg Lys Cys Phe Ile Ser Tyr 
                485                 490                 495     


Ala Asp Ser Val Ser Glu Phe Thr Lys Leu Ile Tyr Leu Leu Thr Arg 
            500                 505                 510         


Phe Leu Ser Gly Lys Glu Ile Asn Asp Leu Val Thr Thr Leu Ile Asn 
        515                 520                 525             


Lys Phe Asp Asn Ile Arg Ser Phe Leu Glu Ile Met Asp Glu Leu Gly 
    530                 535                 540                 


Leu Asp Arg Thr Phe Thr Ala Glu Tyr Ser Phe Phe Glu Gly Ser Thr 
545                 550                 555                 560 


Lys Tyr Leu Ala Glu Leu Val Glu Leu Asn Ser Phe Val Lys Ser Cys 
                565                 570                 575     


Ser Phe Asp Ile Asn Ala Lys Arg Thr Met Tyr Arg Asp Ala Leu Asp 
            580                 585                 590         


Ile Leu Gly Ile Lys Ser Gly Lys Thr Glu Glu Asp Ile Glu Lys Met 
        595                 600                 605             


Ile Asp Asn Ile Leu Gln Ile Asp Ala Asn Gly Asp Lys Lys Leu Lys 
    610                 615                 620                 


Lys Asn Asn Gly Leu Arg Asn Phe Ile Ala Ser Asn Val Ile Asp Ser 
625                 630                 635                 640 


Asn Arg Phe Lys Tyr Leu Val Arg Tyr Gly Asn Pro Lys Lys Ile Arg 
                645                 650                 655     


Glu Thr Ala Lys Cys Lys Pro Ala Val Arg Phe Val Leu Asn Glu Ile 
            660                 665                 670         


Pro Asp Ala Gln Ile Glu Arg Tyr Tyr Glu Ala Cys Cys Pro Glu Asn 
        675                 680                 685             


Thr Ala Leu Cys Ser Ala Asn Lys Lys Arg Glu Lys Leu Ala Asp Met 
    690                 695                 700                 


Ile Ala Glu Ile Glu Phe Glu Asn Phe Ser Asp Ala Gly Asn Tyr Gln 
705                 710                 715                 720 


Lys Ala Asn Val Thr Ser Lys Thr His Glu Ala Glu Ile Lys Arg Lys 
                725                 730                 735     


Asn Gln Ser Ile Ile Arg Leu Tyr Leu Thr Val Met Tyr Ile Met Leu 
            740                 745                 750         


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Phe His Cys 
        755                 760                 765             


Val Glu Arg Asp Thr Lys Leu Tyr Ala Glu Ser Gly Leu Glu Val Gly 
    770                 775                 780                 


Asn Ile Glu Lys Asn Lys Thr Asn Leu Thr Met Ala Val Met Gly Val 
785                 790                 795                 800 


Lys Leu Glu Asn Gly Ile Ile Lys Thr Glu Phe Asp Lys Ser Leu Ala 
                805                 810                 815     


Glu Asn Ala Ala Asn Arg Tyr Leu Arg Asn Ala Arg Trp Tyr Lys Leu 
            820                 825                 830         


Ile Leu Asp Asn Leu Lys Lys Ser Glu Arg Ala Val Val Asn Glu Phe 
        835                 840                 845             


Arg Asn Thr Val Cys His Leu Asn Ala Ile Arg Asn Ile Asn Ile Lys 
    850                 855                 860                 


Glu Ile Lys Glu Val Glu Asn Tyr Phe Ala Leu Tyr His Tyr Leu Ile 
865                 870                 875                 880 


Gln Lys His Leu Glu Asn Arg Phe Ala Asp Lys Lys Val Glu Arg Asp 
                885                 890                 895     


Thr Gly Asp Phe Ile Ser Lys Leu Glu Glu His Lys Thr Tyr Cys Lys 
            900                 905                 910         


Asp Phe Val Lys Ala Tyr Cys Thr Pro Phe Gly Tyr Asn Leu Val Arg 
        915                 920                 925             


Tyr Lys Asn Leu Thr Ile Asp Gly Leu Phe Asp Lys Asn Tyr Pro Gly 
    930                 935                 940                 


Lys Asp Asp Ser Asp Lys Gln Lys 
945                 950         


<210>  2997
<211>  954
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2997

Met Gly Lys Lys Ile His Ala Arg Asp Leu Arg Glu Gln Arg Lys Thr 
1               5                   10                  15      


Asp Arg Thr Glu Lys Phe Ala Asp Gln Asn Lys Lys Arg Glu Ala Glu 
            20                  25                  30          


Arg Ala Val Gln Lys Lys Asp Ala Ala Val Ser Val Lys Ser Val Ser 
        35                  40                  45              


Ser Val Ser Ser Lys Lys Asp Asn Ala Thr Lys Ser Met Ala Lys Ala 
    50                  55                  60                  


Ala Gly Val Lys Ser Val Phe Ala Val Gly Asn Thr Val Tyr Met Thr 
65                  70                  75                  80  


Ser Phe Gly Arg Gly Asn Asp Ala Val Leu Glu Gln Lys Ile Val Asp 
                85                  90                  95      


Thr Ser His Glu Pro Leu Asn Ile Asp Asp Pro Ala Tyr Gln Leu Asn 
            100                 105                 110         


Val Val Thr Met Asn Gly Tyr Ser Val Thr Gly His Arg Gly Glu Thr 
        115                 120                 125             


Val Ser Ala Val Thr Asp Asn Pro Leu Arg Arg Phe Asn Gly Gly Lys 
    130                 135                 140                 


Lys Asp Glu Pro Glu Gln Ser Val Pro Thr Asp Met Leu Cys Leu Lys 
145                 150                 155                 160 


Pro Thr Leu Glu Lys Lys Phe Phe Gly Lys Glu Phe Asp Asp Asn Ile 
                165                 170                 175     


His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala 
            180                 185                 190         


Val Tyr Ser Thr Asn Ala Ile Tyr Ala Leu Asn Asn Met Ser Ala Asp 
        195                 200                 205             


Glu Asn Ile Glu Asn Ser Asp Phe Phe Met Lys Arg Thr Thr Asp Glu 
    210                 215                 220                 


Thr Phe Asp Asp Phe Glu Lys Lys Lys Glu Ser Thr Asn Ser Arg Glu 
225                 230                 235                 240 


Lys Ala Asp Phe Asp Ala Phe Glu Lys Phe Ile Ala Asn Tyr Arg Leu 
                245                 250                 255     


Ala Tyr Phe Ala Asp Ala Phe Tyr Val Asn Lys Lys Asn Pro Lys Gly 
            260                 265                 270         


Lys Ala Arg Asn Val Leu Arg Glu Asp Lys Glu Leu Tyr Ser Val Leu 
        275                 280                 285             


Thr Leu Ile Gly Lys Leu Arg His Trp Cys Val His Ser Glu Glu Gly 
    290                 295                 300                 


Arg Ala Glu Phe Trp Leu Tyr Lys Leu Asp Glu Leu Lys Asp Asp Phe 
305                 310                 315                 320 


Lys Asn Val Leu Asp Val Val Tyr Asn Arg Pro Val Glu Glu Ile Asn 
                325                 330                 335     


Asn Arg Phe Ile Glu Asn Asn Lys Val Asn Ile Gln Ile Leu Gly Ser 
            340                 345                 350         


Val Tyr Lys Asn Thr Asp Ile Ala Glu Leu Val Arg Ser Tyr Tyr Glu 
        355                 360                 365             


Phe Leu Ile Thr Lys Lys Tyr Lys Asn Met Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Ser Met Leu Glu Gly Lys Gly Tyr Ala Asp Lys Glu Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Asn Lys Leu Tyr Gln Met Thr Asp Phe Ile Leu Tyr 
                405                 410                 415     


Thr Gly Tyr Ile Asn Glu Asp Ser Asp Arg Ala Asp Asp Leu Val Asn 
            420                 425                 430         


Thr Leu Arg Ser Ser Leu Lys Glu Asp Asp Lys Thr Thr Val Tyr Cys 
        435                 440                 445             


Lys Glu Ala Asp Tyr Leu Trp Lys Lys Tyr Cys Glu Ser Ile Arg Glu 
    450                 455                 460                 


Val Ala Glu Ala Leu Asp Gly Asp Asn Ile Lys Arg Leu Ser Lys Ser 
465                 470                 475                 480 


Asn Ile Glu Ile Arg Asp Asn Glu Leu Arg Lys Cys Phe Ile Ser Tyr 
                485                 490                 495     


Ala Asp Ser Val Ser Glu Phe Thr Lys Leu Ile Tyr Leu Leu Thr Arg 
            500                 505                 510         


Phe Leu Ser Gly Lys Glu Ile Asn Asp Leu Val Thr Thr Leu Ile Asn 
        515                 520                 525             


Lys Phe Asp Asn Ile Arg Ser Phe Leu Glu Ile Met Asp Glu Leu Gly 
    530                 535                 540                 


Leu Asp Arg Thr Phe Thr Ala Glu Tyr Ser Phe Phe Glu Asp Ser Thr 
545                 550                 555                 560 


Lys Tyr Leu Ala Glu Leu Val Glu Leu Asn Ser Phe Val Lys Ser Cys 
                565                 570                 575     


Ser Phe Asp Ile Asn Ala Lys Arg Thr Met Tyr Arg Asp Ala Leu Asp 
            580                 585                 590         


Ile Leu Gly Ile Lys Ser Gly Lys Thr Glu Glu Asp Ile Glu Lys Met 
        595                 600                 605             


Ile Asp Asn Ile Leu Gln Ile Asp Ala Asn Gly Asp Lys Lys Leu Lys 
    610                 615                 620                 


Lys Asn Asn Gly Leu Arg Asn Phe Ile Ala Ser Asn Val Ile Asp Ser 
625                 630                 635                 640 


Asn Arg Phe Lys Tyr Leu Val Arg Tyr Gly Asn Pro Lys Lys Ile Arg 
                645                 650                 655     


Glu Thr Ala Lys Cys Lys Pro Ala Val Arg Phe Val Leu Asn Glu Ile 
            660                 665                 670         


Pro Asp Ala Gln Ile Glu Arg Tyr Tyr Glu Ala Cys Cys Pro Lys Asn 
        675                 680                 685             


Thr Ala Leu Cys Ser Ala Asn Lys Arg Arg Glu Lys Leu Ala Asp Met 
    690                 695                 700                 


Ile Ala Glu Ile Lys Phe Glu Asn Phe Ser Asp Ala Gly Asn Tyr Gln 
705                 710                 715                 720 


Lys Ala Asn Val Thr Ser Lys Thr His Glu Ala Glu Ile Lys Arg Lys 
                725                 730                 735     


Asn Gln Ala Ile Ile Arg Leu Tyr Leu Thr Val Met Tyr Ile Met Leu 
            740                 745                 750         


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Phe His Cys 
        755                 760                 765             


Val Glu Arg Asp Thr Lys Leu Tyr Ala Glu Ser Gly Leu Glu Val Gly 
    770                 775                 780                 


Asn Ile Glu Lys Asn Lys Thr Asn Leu Thr Met Ala Val Met Gly Val 
785                 790                 795                 800 


Lys Leu Glu Asn Gly Ile Ile Lys Thr Glu Phe Asp Lys Ser Leu Ala 
                805                 810                 815     


Glu Asn Ala Ala Asn Arg Tyr Leu Arg Asn Ala Arg Trp Tyr Lys Leu 
            820                 825                 830         


Ile Leu Asp Asn Leu Lys Lys Ser Glu Arg Ala Val Val Thr Asp Phe 
        835                 840                 845             


Arg Asn Thr Val Cys His Leu Asn Ala Ile Arg Asn Ile Asn Ile Asn 
    850                 855                 860                 


Ile Asp Gly Ile Lys Glu Val Glu Asn Tyr Phe Ala Leu Tyr His Tyr 
865                 870                 875                 880 


Leu Ile Gln Lys His Leu Glu Asn Arg Phe Ala Asp Lys Lys Val Glu 
                885                 890                 895     


Arg Asp Thr Gly Asp Phe Ile Ser Lys Leu Glu Glu His Lys Thr Tyr 
            900                 905                 910         


Cys Lys Asp Phe Val Lys Ala Tyr Cys Thr Pro Phe Gly Tyr Asn Leu 
        915                 920                 925             


Val Arg Tyr Lys Asn Leu Thr Ile Asp Gly Leu Phe Asp Lys Asn Tyr 
    930                 935                 940                 


Pro Gly Lys Asp Asp Ser Asp Glu Gln Lys 
945                 950                 


<210>  2998
<211>  939
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2998

Met Ala Lys Lys Lys Arg Ile Thr Ala Lys Glu Arg Lys Gln Asn His 
1               5                   10                  15      


Arg Glu Ser Leu Met Lys Lys Ala Asp Ser Asn Ala Glu Lys Glu Lys 
            20                  25                  30          


Ala Lys Lys Pro Val Val Glu Asn Lys Pro Asp Thr Ala Ile Ser Lys 
        35                  40                  45              


Asp Asn Ile Pro Lys Pro Asn Lys Glu Ile Lys Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Ala Gly Val Lys Trp Val Ile Lys Ala Asn Asp Asp Val Ala Tyr 
65                  70                  75                  80  


Ile Ser Ser Phe Gly Lys Gly Asn Asn Ser Val Leu Glu Lys Arg Ile 
                85                  90                  95      


Met Gly Asp Val Ser Ser Asn Val Asn Lys Asp Ser His Met Tyr Val 
            100                 105                 110         


Asn Pro Lys Tyr Thr Lys Lys Asn Tyr Glu Ile Lys Asn Gly Phe Ser 
        115                 120                 125             


Ser Gly Ser Ser Leu Val Thr Tyr Pro Asn Lys Pro Asp Lys Asn Ser 
    130                 135                 140                 


Gly Met Asp Ala Leu Cys Leu Lys Pro Tyr Phe Glu Lys Asp Phe Phe 
145                 150                 155                 160 


Gly His Ile Phe Thr Asp Asn Met His Ile Gln Ala Ile Tyr Asn Ile 
                165                 170                 175     


Phe Asp Ile Glu Lys Ile Leu Ala Lys His Ile Thr Asn Ile Ile Tyr 
            180                 185                 190         


Thr Val Asn Ser Phe Asp Arg Asn Tyr Asn Gln Ser Gly Asn Asp Thr 
        195                 200                 205             


Ile Gly Phe Asp Ile Asn Tyr Arg Val Pro Tyr Ser Glu Tyr Gly Gly 
    210                 215                 220                 


Gly Lys Asp Ser Asn Gly Glu Pro Lys Asn Lys Ser Lys Trp Glu Lys 
225                 230                 235                 240 


Arg Lys Asn Phe Ile Lys Phe Tyr Asn Lys Ser Lys Pro His Leu Gly 
                245                 250                 255     


Tyr Tyr Glu Asn Ile Phe Tyr Asp His Gly Glu Pro Ile Ser Glu Glu 
            260                 265                 270         


Lys Phe Tyr Asn Tyr Leu Asn Ile Leu Asn Phe Ile Arg Asn Asn Thr 
        275                 280                 285             


Phe His Tyr Lys Asn Asp Asp Ile Glu Leu Tyr Ser Glu Asn Tyr Ser 
    290                 295                 300                 


Glu Glu Phe Val Phe Ile Asn Cys Leu Asn Lys Phe Val Lys Asn Lys 
305                 310                 315                 320 


Phe Lys Asn Val Asn Lys Asn Phe Ile Ser Asn Glu Lys Asn Asn Leu 
                325                 330                 335     


Tyr Ile Ile Leu Asn Ala Tyr Gly Lys Asp Thr Glu Asn Val Glu Val 
            340                 345                 350         


Val Lys Lys Tyr Ser Lys Glu Leu Tyr Lys Leu Ser Val Leu Lys Thr 
        355                 360                 365             


Asn Lys Asn Leu Gly Val Asn Val Lys Lys Leu Arg Glu Ser Ala Ile 
    370                 375                 380                 


Glu Tyr Gly Tyr Cys Pro Leu Pro Tyr Asp Lys Glu Lys Glu Val Ala 
385                 390                 395                 400 


Lys Leu Ser Ser Ile Lys His Lys Leu Tyr Lys Thr Tyr Asp Phe Val 
                405                 410                 415     


Ile Thr His Tyr Leu Asn Ser Asn Asp Lys Leu Leu Leu Glu Ile Val 
            420                 425                 430         


Glu Ala Leu Arg Leu Ser Lys Asn Asp Asp Glu Lys Glu Asn Val Tyr 
        435                 440                 445             


Lys Lys Tyr Ala Glu Lys Leu Phe Lys Ala Asp Asp Val Ile Asn Pro 
    450                 455                 460                 


Ile Lys Ala Ile Ser Lys Leu Phe Ala Glu Lys Gly Asn Lys Leu Phe 
465                 470                 475                 480 


Lys Glu Met Val Ile Ile Lys Lys Glu Tyr Val Glu Asp Ile Ser Ile 
                485                 490                 495     


Asp Lys Asn Ile Tyr Asp Phe Thr Lys Val Ile Phe Phe Met Thr Cys 
            500                 505                 510         


Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Asn Ile Ile Ser 
        515                 520                 525             


Lys Leu Gln Val Ile Glu Asp His Asn Asn Val Ile Lys Phe Ile Ser 
    530                 535                 540                 


Asn Asn Lys Asp Ala Val Tyr Lys Asp Tyr Ser Asp Lys Tyr Ala Ile 
545                 550                 555                 560 


Phe Arg Asn Ala Gly Lys Ile Ala Thr Glu Leu Glu Ala Ile Lys Ser 
                565                 570                 575     


Ile Val Arg Met Glu Asn Lys Ile Glu Asn Ala Pro Gln Glu Pro Leu 
            580                 585                 590         


Leu Lys Asp Ala Leu Leu Ser Leu Gly Val Ser Asp Asp Thr Lys Val 
        595                 600                 605             


Leu Glu Asn Thr Tyr Lys Lys Tyr Phe Asp Ser Lys Glu Lys Ala Asp 
    610                 615                 620                 


Lys Gln Ser Gln Lys Val Ser Thr Phe Leu Met Asn Asn Val Ile Asn 
625                 630                 635                 640 


Asn Asn Arg Phe Lys Tyr Val Ile Lys Tyr Ile Asn Pro Ala Asp Ile 
                645                 650                 655     


Asn Gly Leu Ala Lys Asn Arg Tyr Leu Val Lys Phe Val Leu Ser Asn 
            660                 665                 670         


Ile Pro Glu Glu Gln Ile Asp Ser Tyr Tyr Lys Leu Phe Ser Asn Glu 
        675                 680                 685             


Glu Glu Pro Ser Cys Glu Glu Lys Ile Lys Leu Leu Thr Lys Lys Ile 
    690                 695                 700                 


Ser Lys Leu Asn Phe Gln Thr Leu Phe Glu Asn Asn Lys Ile Pro Asn 
705                 710                 715                 720 


Val Glu Lys Glu Arg Lys Lys Ala Ile Ile Thr Leu Tyr Phe Thr Ile 
                725                 730                 735     


Val Tyr Ile Leu Val Lys Asn Leu Val Asn Ile Asn Gly Leu Tyr Thr 
            740                 745                 750         


Leu Ala Leu Tyr Phe Val Glu Arg Asp Gly Tyr Phe Tyr Lys Asp Ile 
        755                 760                 765             


Cys Gly Lys Lys Asp Lys Lys Lys Ser Tyr Asn Gly Val Asp Tyr Leu 
    770                 775                 780                 


Leu Leu Pro Glu Ile Phe Ser Gly Ser Lys Tyr Arg Glu Gln Thr Lys 
785                 790                 795                 800 


Asn Leu Lys Leu Pro Lys Glu Lys Asp Arg Asp Ile Met Lys Lys Tyr 
                805                 810                 815     


Leu Pro Asn Asp Lys Asp Arg Glu Gly Tyr Asn Lys Phe Phe Arg Ala 
            820                 825                 830         


Tyr Arg Asn Asn Ile Val His Leu Asn Ile Ile Ala Lys Leu Ser Glu 
        835                 840                 845             


Leu Thr Ser Asn Ile Asp Lys Asp Ile Asn Ser Tyr Phe Asp Ile Tyr 
    850                 855                 860                 


His Tyr Cys Thr Gln Arg Val Met Phe Asn Tyr Cys Lys Glu Asn Asn 
865                 870                 875                 880 


Asn Ile Val Leu Ala Lys Met Lys Asp Leu Ala His Ile Lys Ser Asp 
                885                 890                 895     


Cys Asp Glu Phe Ser Ser Lys His Thr Tyr Pro Phe Ser Ser Ala Val 
            900                 905                 910         


Leu Arg Phe Met Asn Leu Pro Phe Ala Tyr Asn Val Pro Arg Phe Lys 
        915                 920                 925             


Asn Leu Ser Tyr Lys Lys Phe Phe Asp Lys Gln 
    930                 935                 


<210>  2999
<211>  923
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  2999

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Val Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Glu Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asn Ser Ser Asn Ile Glu Leu Arg Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Gly Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu His Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Asp Asp Tyr 
            340                 345                 350         


Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys 
        355                 360                 365             


Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met 
    370                 375                 380                 


Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val 
385                 390                 395                 400 


Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr 
                405                 410                 415     


Tyr Arg Asn Asp Val Ile Ala Gly Glu Ala Leu Val Arg Lys Leu Arg 
            420                 425                 430         


Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala 
        435                 440                 445             


Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp 
    450                 455                 460                 


His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp 
465                 470                 475                 480 


Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu 
                485                 490                 495     


Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly 
            500                 505                 510         


Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn 
        515                 520                 525             


Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu 
    530                 535                 540                 


Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile 
545                 550                 555                 560 


Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro 
                565                 570                 575     


Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu 
            580                 585                 590         


Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys 
        595                 600                 605             


Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr 
    610                 615                 620                 


Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala 
625                 630                 635                 640 


Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met 
                645                 650                 655     


Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys 
            660                 665                 670         


Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg 
        675                 680                 685             


Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys 
    690                 695                 700                 


Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg 
705                 710                 715                 720 


Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val 
                725                 730                 735     


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys 
            740                 745                 750         


Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala 
        755                 760                 765             


Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys 
    770                 775                 780                 


Glu Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys 
785                 790                 795                 800 


Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp 
                805                 810                 815     


Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val 
            820                 825                 830         


Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser 
        835                 840                 845             


Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg 
    850                 855                 860                 


Glu Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu 
865                 870                 875                 880 


Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser 
                885                 890                 895     


Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln 
            900                 905                 910         


Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920             


<210>  3000
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3000

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Ser Ser Asn Ile Glu Leu Arg Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Lys Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe Thr Asn 
    210                 215                 220                 


Pro Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Lys Asn Ile Arg Lys 
225                 230                 235                 240 


Ser Leu Arg Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu His Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Ile Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Lys Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Arg Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  3001
<211>  1057
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3001

Met Glu Glu Asn Lys Val Arg Phe Thr Asn Thr Ser Asn Val Lys Arg 
1               5                   10                  15      


Pro Lys Ser Leu Leu Lys Gln Met Gly His Lys Ser Thr Phe Leu Leu 
            20                  25                  30          


Asp Asp Thr Leu Ile Val Thr Ser Val Ala Lys Gly Lys Asn Glu Asp 
        35                  40                  45              


Gln Lys Gly Lys Glu Gln Ala Ala Ser Lys Ser Lys Val Ala Pro Gln 
    50                  55                  60                  


Ser His Ile Glu Leu Leu Ser Thr Ile Asp Gly Glu Val Leu Gly Gly 
65                  70                  75                  80  


Arg Lys Glu Leu Leu Ala Thr Thr Val Ser Arg Gln Glu Val Thr Ile 
                85                  90                  95      


Ser Gly Lys Ile Tyr Asn Leu Asn Thr Lys Thr Pro Glu Ser Thr Thr 
            100                 105                 110         


Val Thr Met Ala Asn Pro Ala Val Leu Leu Gln Lys Asn Ser Ser Thr 
        115                 120                 125             


Thr Gln Val Ala Arg Lys Thr Asp Tyr Leu Gly Ile Lys Ser Ala Leu 
    130                 135                 140                 


Glu Lys Glu Phe Phe Asn Asp Phe Ser Asn Ser Gly Phe Asn Asp Asn 
145                 150                 155                 160 


Val Arg Val Gln Ile Ala Tyr Asn Ile Leu Asp Ile Arg Lys Ile Leu 
                165                 170                 175     


Ala Thr Thr Ile Asn Asn Ile Val Ser Met Phe Tyr Asn Leu Asp Arg 
            180                 185                 190         


Thr Thr Gly Asp Ile Ala Asp Glu Thr Lys Lys Ser Thr Asn Thr Asp 
        195                 200                 205             


Ile Ile Gly Met Ile Lys Thr Tyr Leu Lys Tyr Asp Gln Ala Lys Asn 
    210                 215                 220                 


Ser Asn Asp Pro Ser Ile Lys Lys Thr Phe Asn Lys Ala Glu Glu Leu 
225                 230                 235                 240 


Leu Ile Asn Thr Lys Ala Tyr His Thr Tyr Phe Asp Arg Leu Phe Thr 
                245                 250                 255     


Thr Pro Thr Arg Gln Ala Phe Lys Ala Gly Lys Leu Lys Asp Thr Asn 
            260                 265                 270         


Asp Lys Lys Ser Asn Leu Pro Cys Glu Phe Ser Lys Leu Ser Glu Lys 
        275                 280                 285             


Asp Gln Glu Glu Phe Lys Asn Glu Ala Ile Thr His Asn Tyr Asp Val 
    290                 295                 300                 


Leu Arg Leu Leu Gly Leu Gly Arg Gln Leu Val Val His Glu Lys Tyr 
305                 310                 315                 320 


Lys Ser Asp Glu His Asn Lys Asp Asn Ser Ile Glu Ser Leu Phe Asn 
                325                 330                 335     


Ile Asp Lys Ile Ile Arg Asn Ser Asn Asp Thr Met Asp Leu Leu Lys 
            340                 345                 350         


Arg Leu Asp Asn Ile Tyr Leu Glu Ser Ala Glu Gln Ile Asp Asn Ser 
        355                 360                 365             


Phe Lys Lys Ser Ser Ala Thr Asn Cys Leu Ile Leu Glu Glu Leu Tyr 
    370                 375                 380                 


Lys Arg Ile Gly Lys Ala Lys Thr Gln Ala Glu Leu Tyr Lys Asp Tyr 
385                 390                 395                 400 


Tyr Arg Tyr Ala Ile Leu Lys Glu Asp Gln Cys Leu Gly Ile Ser Phe 
                405                 410                 415     


Asn Arg Ile Lys Glu Ala Val Leu Glu Lys Leu Lys Glu Glu Gln Arg 
            420                 425                 430         


Tyr Lys Asn Phe Glu Tyr Arg Asn Asp Asn Lys Arg Phe Tyr Thr Leu 
        435                 440                 445             


Cys Asn Phe Val Leu Trp His Tyr Met Val Asp Leu Arg Asp Arg Asn 
    450                 455                 460                 


Glu Thr Arg Ala Gly His Gln Gln Thr Asp Arg Asn Glu Ile Glu Glu 
465                 470                 475                 480 


Leu Lys Ser Lys Leu Arg Ala Cys Cys Asp Asn Asn Gly Asp Gly Gly 
                485                 490                 495     


Glu Asn Gln Lys Tyr Ala Ile Tyr Lys Glu Phe Val Asn Phe His Trp 
            500                 505                 510         


Thr Asp Leu Arg Thr Ser Ile Asn Thr Leu Tyr Asp Leu Cys Val Lys 
        515                 520                 525             


Tyr Lys Tyr Thr Ala Lys Asn Tyr Arg Ile Asp Ser Lys Ile Gln Ile 
    530                 535                 540                 


Asp Asn Gln Leu Ser Ser Ser Ala Asn Asn Val Lys Thr Phe Val Lys 
545                 550                 555                 560 


Tyr Ile Tyr Phe Leu Ser Glu Phe Leu Asp Gly Lys Glu Val Asn Val 
                565                 570                 575     


Phe Phe Asn Glu Leu Val Glu Lys Phe Ser Asn Ile Ala Glu Ile Val 
            580                 585                 590         


Thr Thr Val Asn Asp Asn Ile Asn Asn Ser Ser Lys Lys Ser Pro Asn 
        595                 600                 605             


Ile Ser Phe Leu Pro Gln Tyr Ser Leu Phe Gln Glu Ala Gly Thr Val 
    610                 615                 620                 


Ala Asp Gln Leu Arg Asn Ala Arg Asn Ile Lys His Ala Thr Leu Arg 
625                 630                 635                 640 


Ala Arg Ile Asn Asp Lys Val Ala Asp Lys Asp Ser Lys Met Ser Pro 
                645                 650                 655     


Ser Lys Gln Thr Ile Ser Asp Ala Leu Tyr Met Leu Ile Asp Glu Asn 
            660                 665                 670         


Asp Thr Ile Glu Asn Tyr Lys Gln Leu Ile Trp Asp Glu Lys Glu Ser 
        675                 680                 685             


Gly Thr Trp Val Lys Lys Ala Thr Gly Asn Asn Lys Val Arg Asn Phe 
    690                 695                 700                 


Ile Ile Asn Asn Ile Ile Met Ser Lys Trp Phe Met Tyr Ile Ser Lys 
705                 710                 715                 720 


Tyr Ser Asp Pro Arg Asn Cys Ser Lys Ile Met His Asn Lys Glu Ala 
                725                 730                 735     


Val Val Phe Ala Met Ser Ser Ile Pro Asp Ala Gln Ile Glu Lys Tyr 
            740                 745                 750         


Tyr Lys Arg Val Thr Ala Lys Ser Val Gln Tyr Gly Asn Lys Thr Ala 
        755                 760                 765             


Glu Glu Met Arg Ser Ile Val Ile Asp Ala Leu Met Asn Phe Ser Leu 
    770                 775                 780                 


Lys Pro Val Leu Thr Gly Val Ala Asn Asn Asp Tyr Ser Asn Glu Asn 
785                 790                 795                 800 


Arg Glu Arg Asp Ile Gly Ile Ile Gln Leu Tyr Leu Thr Val Ala Tyr 
                805                 810                 815     


Ile Val Thr Lys Ser Leu Val Asn Val Asn Lys Arg Phe Leu Leu Ala 
            820                 825                 830         


Phe Ser Cys Leu Glu Arg Asp Val Pro Leu Ile Leu Asn Gly Lys Ser 
        835                 840                 845             


Phe Lys Asp Ala Asn Ile Leu Val Leu Ser Glu Lys Phe Ile Ala Glu 
    850                 855                 860                 


Asp Gln Glu Ile Glu Gln Lys Tyr Lys Leu Ala Lys Lys Asn Arg Ile 
865                 870                 875                 880 


Thr Pro Asn Met Ser Lys Glu Asp Val Lys Asn Val Phe Lys Glu Leu 
                885                 890                 895     


Asn Ala Glu Tyr Lys Ser Lys His Tyr Ala Glu Ser Leu Thr Arg Pro 
            900                 905                 910         


Arg Asp Pro Asp Ser Lys Lys Asp Lys Ser Cys Ala Tyr Leu Val Asn 
        915                 920                 925             


Asn Leu Asn Glu Ala Lys Lys Ile Glu Asn Val Leu Met Asp Phe Lys 
    930                 935                 940                 


Asn Lys Val Asp His Leu Asn Val Val Lys Ser Ala Pro Glu Tyr Met 
945                 950                 955                 960 


Ser Asn Ile Lys Asn Ile Asp Ser Phe Tyr Gly Ile Phe Cys Phe Ala 
                965                 970                 975     


Leu Gln Asn Ile Leu Ala Asp Lys Met Ile Lys Trp Ser Val Asn Glu 
            980                 985                 990         


Lys Asn Ser Lys Glu Asp Val Glu  Ile Ile Asn Ser Tyr  Gly Gln Glu 
        995                 1000                 1005             


Leu Lys  Lys Lys Leu Asp Ser  Arg His Thr Phe Asp  Arg Asp Ala 
    1010                 1015                 1020             


Met Trp  Ile Ile Asn Met Pro  Phe Ala Tyr Asn Phe  Pro Arg Tyr 
    1025                 1030                 1035             


Lys Asn  Leu Ser Ser Glu Tyr  Leu Phe Tyr Asp Lys  Glu Tyr Glu 
    1040                 1045                 1050             


Lys Thr  Lys Lys 
    1055         


<210>  3002
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3002

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Ile Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Gly Val Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ser Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Cys Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  3003
<211>  951
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3003

Met Lys Gly Thr Val Val Lys Asn Gly Lys Phe Leu Glu Ile Lys Gly 
1               5                   10                  15      


Glu Asn Gly Lys Ile Tyr Gln Leu Lys Pro Phe His Leu Pro Glu Gly 
            20                  25                  30          


Lys Thr Ile Gln Trp Leu Asn Ala Gly Asp Arg Val Thr Phe Arg Thr 
        35                  40                  45              


Lys Asp Lys Gly Arg Ile Ala Glu Lys Ser Val Asp Lys Ile Lys Thr 
    50                  55                  60                  


Tyr Lys Leu Pro Val Thr Pro Arg Thr His Glu Glu Ile Phe Gly Asp 
65                  70                  75                  80  


Lys Ser Ala Gln Arg Pro Lys Thr Lys Ala Lys Ala Ile Gly Leu Lys 
                85                  90                  95      


Ser Leu Leu Tyr Tyr Asp Asp Lys Ile Ile Ala Thr Ser Phe Gly Lys 
            100                 105                 110         


Gly Asn Lys Ala Asn Val Glu Lys Ile Val Ser Asp Lys Ile Glu Asn 
        115                 120                 125             


Ile Tyr Asp Pro Ala Asn Tyr Ser Ile Phe Ile Asn Asp Lys Leu Lys 
    130                 135                 140                 


Ser Phe Val Leu Gln Asp Lys Lys Gly Glu Asn Ser Val Ser Ile Asn 
145                 150                 155                 160 


Leu Phe Asn Ala Thr Ile Ser Asn Glu Ala Asp His Lys Gly Glu Ile 
                165                 170                 175     


Thr Ile Asn Ala Gly Gln Val Gly Arg Asp Gln Ile Gly Leu Lys Asp 
            180                 185                 190         


Ala Leu Glu Glu Lys Ile Phe Gly Lys Thr Tyr Asn Asp Asn Ile His 
        195                 200                 205             


Val Gln Ile Ala Tyr Asn Ile Leu Asp Val Glu Lys Ile Leu Thr Glu 
    210                 215                 220                 


Tyr Ile Asn Asp Ile Val Tyr Ala Met Asn Asn Ala Ala Asp Ile Ser 
225                 230                 235                 240 


Pro Asp Arg Asp Leu Val Gly Tyr Leu Gly His Leu Phe Asn Tyr Gln 
                245                 250                 255     


Lys Tyr Trp Ser Asn Pro Lys Ser Ala Asn Asn Lys Pro Asn Phe Asp 
            260                 265                 270         


Lys Phe Val Asn Ser Pro Arg Leu Ile Asn Tyr Gly Glu Ala Phe Tyr 
        275                 280                 285             


Thr Val Gly Arg Asp Gly Pro Arg Arg Lys Ser Glu Arg Glu Ile Phe 
    290                 295                 300                 


Tyr Met Leu Ser Phe Val Gly Tyr Ala Arg Gln Phe Ile Ala His Glu 
305                 310                 315                 320 


Tyr Gly Lys His Ile Ser Ile Tyr Asn Pro Ala Lys Ala Ala Asp Lys 
                325                 330                 335     


Glu Val Ala Asp Phe Leu Asp Arg Leu Phe Ala Asp Lys Ile Asp Glu 
            340                 345                 350         


Val Asn Ser Asp Phe Leu Lys Leu Asn Ala Lys Asn Ile Ala Ile Ile 
        355                 360                 365             


Cys Asp Ile Phe Pro Asn Glu Asn Arg Asn Thr Leu Ile Lys Glu Phe 
    370                 375                 380                 


Tyr Gln Phe Ser Val Leu Lys Ala His Lys Asn Met Gly Phe Ser Ile 
385                 390                 395                 400 


Lys Thr Leu Arg Glu Thr Leu Leu Ala Leu Glu Gln Ala Gln Gln Leu 
                405                 410                 415     


Arg Ser Tyr Ile Met Gln His Gln Asp Phe Arg Arg Gln Val Asn Thr 
            420                 425                 430         


Gln Leu Asp Phe Met Ile Tyr Lys Arg Tyr Lys Asp Ser Ser Arg Ala 
        435                 440                 445             


Lys Ser Phe Ala Asp Ala Leu Arg Ala Thr Ala Arg Lys Glu Asp Lys 
    450                 455                 460                 


Pro Ala Leu Tyr Ile Ala Glu Ala Ser Lys Leu Tyr Ala Glu Thr Ala 
465                 470                 475                 480 


Lys Phe Ile Thr Thr Gly Ile Leu Ala Ala Leu Asp Ser Lys Gln Ala 
                485                 490                 495     


Gln Lys Leu Glu Asn Phe Pro Ala Ile Pro Pro Glu Ala Ile Lys Asp 
            500                 505                 510         


Val Cys Ile Gly Ser Gln Ala Tyr Asp Phe Val Lys Leu Ile Tyr Leu 
        515                 520                 525             


Phe Thr Leu Leu Leu Asp Gly Lys Glu Ile Asn Asn Leu Leu Thr Gly 
    530                 535                 540                 


Leu Ile Ser Lys Phe Asp Asn Ile Asn Ser Leu Cys Arg Ile Tyr Thr 
545                 550                 555                 560 


Glu Ile Thr Gly Leu Val Asn Leu Glu Asp Arg Tyr Val Lys Phe Glu 
                565                 570                 575     


Lys Asp Tyr Ser Ile Phe Lys Asp Cys Gly Arg Val Val Ala Gln Leu 
            580                 585                 590         


Gln Met Leu Asn Ser Phe Ala Arg Met Gln Lys Arg Pro Asp Ser Gln 
        595                 600                 605             


Thr Asn Ala Lys Ala Lys Lys Ala Lys Asp Pro Phe Ala Lys Thr Asp 
    610                 615                 620                 


Phe Gly Asp Ala Val Met Val Leu Gly Val Ser Pro Gln Asp Lys Lys 
625                 630                 635                 640 


Ala Ala Ile Asp Lys Leu Thr Pro Gly Met Lys Asn Tyr Ile Ser Asn 
                645                 650                 655     


Asn Val Leu Asn Ser Ser Arg Phe Arg Tyr Leu Val Arg Tyr Ala Asp 
            660                 665                 670         


Val Lys Asn Val Ser Ile Leu Ala Lys Ser Lys Val Leu Thr Glu Phe 
        675                 680                 685             


Val Leu Ala Asp Ile Pro Asp Asn Gln Ile Glu Arg Tyr Thr Glu Ser 
    690                 695                 700                 


Cys Gly Gly Asn Ser Ser Leu Ser Val Lys Glu Lys Arg Gln Phe Leu 
705                 710                 715                 720 


Ala Gln Lys Ile Ala Glu Leu Ser Ile Asp Asn Met Tyr Val Glu Met 
                725                 730                 735     


Asp Lys Lys Ala Thr Glu Gln Gln Met Leu Gln Arg Glu Asn Asn Lys 
            740                 745                 750         


Asn Ile Leu Gly Leu Tyr Leu Thr Val Leu Tyr Leu Val Cys Lys Asn 
        755                 760                 765             


Leu Val Asn Val Asn Ala Arg Tyr Leu Met Ala Phe His Cys Leu Ala 
    770                 775                 780                 


Arg Asp Ser Tyr Leu Leu Gly Lys Pro Tyr Lys Lys Asp Asn Val Tyr 
785                 790                 795                 800 


Asp Tyr Ala Val Leu Thr Ala Asp Tyr Ile Arg His Ser Lys Asn Ala 
                805                 810                 815     


His Met Ala Gln Phe Leu Ala Thr Asp Thr Glu Lys Ser Asn Asn Arg 
            820                 825                 830         


Leu Ile His Gln Phe Arg Asn Ser Ala Ala His Leu Gly Ala Val Arg 
        835                 840                 845             


Lys Ala His Leu Tyr Ile Gly Asp Ile Lys Gln Ile Asp Ser Tyr Tyr 
    850                 855                 860                 


Ala Leu Tyr His Tyr Ile Met Gln Arg Gln Val Leu Ala Gln Ala Asp 
865                 870                 875                 880 


Ser Ser Asp Glu Glu Cys Ser Lys Ile Val Leu Lys Tyr Asp Lys Leu 
                885                 890                 895     


Leu Lys Asn His Lys Thr Tyr Cys Lys Asp Phe Val Lys Glu Leu Cys 
            900                 905                 910         


Val Gly Phe Gly Tyr Asn Val Pro Arg Phe Lys Ser Leu Thr Ile Glu 
        915                 920                 925             


Asp Lys Phe Asp Lys Asn Lys Pro Asp Ala Asn Gln Lys Asn Lys Ala 
    930                 935                 940                 


Lys Asn Glu Ala Glu His Cys 
945                 950     


<210>  3004
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3004

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Phe Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Asn Arg Val Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Ile Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Leu Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Lys Val Ala Glu Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp Asp Lys 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Phe Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  3005
<211>  918
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3005

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Gly Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Asn Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp 
    370                 375                 380                 


Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Gly Val Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ser Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu Arg 
785                 790                 795                 800 


Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr Arg 
                805                 810                 815     


Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu Lys 
            820                 825                 830         


Glu Tyr Ile Gly Asp Ile Cys Thr Val Asp Ser Tyr Phe Ser Ile Tyr 
        835                 840                 845             


His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr Lys 
    850                 855                 860                 


Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His Gly 
865                 870                 875                 880 


Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr Asn 
                885                 890                 895     


Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg Asn 
            900                 905                 910         


Glu Tyr Leu Thr Glu Lys 
        915             


<210>  3006
<211>  918
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3006

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Gly Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Asn Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp 
    370                 375                 380                 


Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Gly Val Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ser Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu Arg 
785                 790                 795                 800 


Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr Arg 
                805                 810                 815     


Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu Lys 
            820                 825                 830         


Glu Tyr Ile Gly Asp Ile Cys Thr Val Asp Ser Tyr Phe Ser Ile Tyr 
        835                 840                 845             


His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr Lys 
    850                 855                 860                 


Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His Gly 
865                 870                 875                 880 


Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr Asn 
                885                 890                 895     


Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg Asn 
            900                 905                 910         


Glu Tyr Leu Thr Glu Lys 
        915             


<210>  3007
<211>  926
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3007

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asp Asp Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Ser Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Phe Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Asp Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Lys Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Cys Val Phe His Asp Lys Ser Ser Lys Leu His Glu 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe 
                325                 330                 335     


Ile Glu Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Asp Asp Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile 
        355                 360                 365             


Val Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg 
    370                 375                 380                 


Glu Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe 
                405                 410                 415     


Cys Asn Tyr Tyr Arg Asn Asp Val Ala Val Gly Glu Ala Leu Val Arg 
            420                 425                 430         


Lys Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala 
        435                 440                 445             


Asp Glu Ala Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn 
    450                 455                 460                 


Ile Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala 
465                 470                 475                 480 


Asp Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala 
                485                 490                 495     


Ser Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe 
            500                 505                 510         


Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys 
        515                 520                 525             


Phe Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val 
    530                 535                 540                 


Asp Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser 
545                 550                 555                 560 


Gln Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met 
                565                 570                 575     


Arg Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu 
            580                 585                 590         


Thr Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu 
        595                 600                 605             


Ile Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn 
    610                 615                 620                 


Phe Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile 
625                 630                 635                 640 


Lys Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys 
                645                 650                 655     


Val Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg 
            660                 665                 670         


Tyr Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu 
        675                 680                 685             


Ala Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp 
    690                 695                 700                 


Asp Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala 
705                 710                 715                 720 


Lys Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr 
                725                 730                 735     


Leu Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala 
            740                 745                 750         


Ile His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro 
        755                 760                 765             


Glu Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln 
    770                 775                 780                 


Thr Leu Cys Glu Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe 
785                 790                 795                 800 


Leu Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn 
                805                 810                 815     


Asn Ala Asp Ser Ile Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His 
            820                 825                 830         


Leu Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr 
        835                 840                 845             


Val Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile 
    850                 855                 860                 


Thr Lys Arg Glu Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu 
865                 870                 875                 880 


Asp Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala 
                885                 890                 895     


Leu Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser 
            900                 905                 910         


Ile Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925     


<210>  3008
<211>  918
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3008

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Gly Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Asn Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Gly Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp 
    370                 375                 380                 


Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Gly Val Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ser Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu Arg 
785                 790                 795                 800 


Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr Arg 
                805                 810                 815     


Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu Lys 
            820                 825                 830         


Glu Tyr Ile Gly Asp Ile Cys Thr Val Asp Ser Tyr Phe Ser Ile Tyr 
        835                 840                 845             


His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr Lys 
    850                 855                 860                 


Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His Gly 
865                 870                 875                 880 


Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr Asn 
                885                 890                 895     


Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg Asn 
            900                 905                 910         


Glu Tyr Leu Thr Glu Lys 
        915             


<210>  3009
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3009

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Lys Asn Asp Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Val 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Glu Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Asp Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Gly Asp Glu Ser His Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe Thr Asp 
    210                 215                 220                 


Pro Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Asn Arg Val Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu His Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Ile Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Glu 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ser Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Lys Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Arg Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  3010
<211>  918
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3010

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Gly Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Asn Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp 
    370                 375                 380                 


Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Gly Val Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ser Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu Arg 
785                 790                 795                 800 


Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr Arg 
                805                 810                 815     


Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu Lys 
            820                 825                 830         


Glu Tyr Ile Gly Asp Ile Cys Thr Val Asp Ser Tyr Phe Ser Ile Tyr 
        835                 840                 845             


His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr Lys 
    850                 855                 860                 


Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His Gly 
865                 870                 875                 880 


Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr Asn 
                885                 890                 895     


Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg Asn 
            900                 905                 910         


Glu Tyr Leu Thr Glu Lys 
        915             


<210>  3011
<211>  954
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3011

Met Gly Lys Lys Ile His Ala Arg Asp Leu Arg Glu Gln Arg Lys Thr 
1               5                   10                  15      


Asp Arg Thr Glu Lys Phe Ala Asp Gln Asn Lys Lys Arg Glu Ala Glu 
            20                  25                  30          


Arg Ala Val Gln Lys Lys Asp Ala Ala Val Ser Val Lys Ser Val Ser 
        35                  40                  45              


Ser Val Ser Ser Lys Lys Asp Asn Val Thr Lys Ser Met Ala Lys Ala 
    50                  55                  60                  


Ala Gly Val Lys Ser Val Phe Ala Val Gly Asn Thr Val Tyr Met Thr 
65                  70                  75                  80  


Ser Phe Gly Arg Gly Asn Asp Ala Val Leu Glu Gln Lys Ile Val Asp 
                85                  90                  95      


Thr Ser His Glu Pro Leu Asn Ile Asp Asp Pro Ala Tyr Gln Leu Asn 
            100                 105                 110         


Val Val Thr Met Asn Gly Tyr Ser Val Thr Gly His Arg Gly Glu Thr 
        115                 120                 125             


Val Ser Ala Val Thr Asp Asn Pro Leu Arg Arg Phe Asn Gly Gly Lys 
    130                 135                 140                 


Lys Asp Glu Pro Glu Gln Ser Val Pro Thr Asp Met Leu Cys Leu Lys 
145                 150                 155                 160 


Pro Thr Leu Glu Lys Lys Phe Phe Gly Lys Glu Phe Asn Asp Asn Ile 
                165                 170                 175     


His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala 
            180                 185                 190         


Val Tyr Ser Thr Asn Ala Ile Tyr Ala Leu Asn Asn Met Ser Ala Asp 
        195                 200                 205             


Glu Asn Ile Glu Asn Ser Asp Phe Phe Met Lys Arg Thr Thr Asp Glu 
    210                 215                 220                 


Thr Phe Asp Asp Phe Glu Lys Lys Lys Glu Ser Thr Asn Ser Arg Glu 
225                 230                 235                 240 


Lys Ala Asp Phe Asp Ala Phe Glu Lys Phe Ile Gly Asn Tyr Arg Leu 
                245                 250                 255     


Ala Tyr Phe Ala Asp Ala Phe Tyr Val Asn Lys Lys Asn Pro Lys Gly 
            260                 265                 270         


Lys Ala Lys Asn Val Leu Arg Glu Asp Lys Glu Leu Tyr Ser Val Leu 
        275                 280                 285             


Thr Leu Ile Gly Lys Leu Arg His Trp Cys Val His Ser Glu Asp Gly 
    290                 295                 300                 


Arg Ala Glu Phe Trp Leu Tyr Lys Leu Asp Glu Leu Lys Asp Asp Phe 
305                 310                 315                 320 


Lys Asn Val Leu Asp Val Val Tyr Asn Arg Pro Val Glu Glu Ile Asn 
                325                 330                 335     


Asn Arg Phe Ile Glu Asn Asn Lys Val Asn Ile Gln Ile Leu Gly Ser 
            340                 345                 350         


Val Tyr Lys Asn Thr Asp Ile Ala Glu Leu Val Arg Ser Tyr Tyr Glu 
        355                 360                 365             


Phe Leu Ile Thr Lys Lys Tyr Lys Asn Met Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Ser Met Leu Glu Gly Lys Gly Tyr Ala Asp Lys Glu Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Asn Lys Leu Tyr Gln Met Thr Asp Phe Ile Leu Tyr 
                405                 410                 415     


Thr Gly Tyr Ile Asn Glu Asp Ser Asp Arg Ala Asp Asp Leu Val Asn 
            420                 425                 430         


Thr Leu Arg Ser Ser Leu Lys Glu Asp Asp Lys Thr Thr Val Tyr Cys 
        435                 440                 445             


Lys Glu Ala Asp Tyr Leu Trp Lys Lys Tyr Arg Glu Ser Ile Arg Glu 
    450                 455                 460                 


Val Ala Asp Ala Leu Asp Val Asp Asn Ile Lys Asn Leu Ser Gly Ser 
465                 470                 475                 480 


Asn Ile Glu Ile Arg Asp Asn Glu Leu Arg Lys Cys Phe Ile Ser Tyr 
                485                 490                 495     


Ala Asp Ser Val Ser Glu Phe Thr Lys Leu Ile Tyr Leu Leu Thr Arg 
            500                 505                 510         


Phe Leu Ser Gly Lys Glu Ile Asn Asp Leu Val Thr Thr Leu Ile Asn 
        515                 520                 525             


Lys Phe Asp Asn Ile Arg Ser Phe Leu Glu Ile Met Asp Glu Leu Gly 
    530                 535                 540                 


Leu Asp Arg Thr Phe Thr Ala Glu Tyr Ser Phe Phe Glu Gly Ser Thr 
545                 550                 555                 560 


Lys Tyr Leu Ala Glu Leu Val Glu Leu Asn Ser Phe Val Lys Ser Cys 
                565                 570                 575     


Ser Phe Asp Ile Asn Ala Lys Arg Thr Met Tyr Arg Asp Ala Leu Asp 
            580                 585                 590         


Ile Leu Gly Ile Lys Ser Gly Lys Thr Glu Glu Asp Ile Glu Lys Met 
        595                 600                 605             


Ile Asp Asn Ile Leu Gln Ile Asp Ala Asn Gly Asp Lys Lys Leu Lys 
    610                 615                 620                 


Lys Asn Asn Gly Leu Arg Asn Phe Ile Ala Ser Asn Val Ile Asp Ser 
625                 630                 635                 640 


Asn Arg Phe Lys Tyr Leu Val Arg Tyr Gly Asn Pro Lys Lys Ile Arg 
                645                 650                 655     


Glu Thr Ala Lys Cys Lys Pro Ala Val Arg Phe Val Leu Asn Glu Ile 
            660                 665                 670         


Pro Asp Ala Gln Ile Glu Arg Tyr Tyr Glu Ala Cys Cys Pro Lys Asn 
        675                 680                 685             


Thr Ala Leu Cys Ser Ala Asn Lys Arg Arg Glu Lys Leu Ala Asp Met 
    690                 695                 700                 


Ile Ala Glu Ile Lys Phe Glu Asn Phe Ser Asp Ala Gly Asn Tyr Gln 
705                 710                 715                 720 


Lys Ala Asn Val Thr Ser Arg Thr Ser Glu Ala Glu Ile Lys Arg Lys 
                725                 730                 735     


Asn Gln Ala Ile Ile Arg Leu Tyr Leu Thr Val Met Tyr Ile Met Leu 
            740                 745                 750         


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Phe His Cys 
        755                 760                 765             


Val Glu Arg Asp Thr Lys Leu Tyr Ala Glu Ser Gly Leu Glu Val Gly 
    770                 775                 780                 


Asn Ile Glu Lys Asn Lys Thr Asn Leu Thr Met Ala Val Met Gly Val 
785                 790                 795                 800 


Lys Leu Glu Asn Gly Thr Ile Lys Thr Glu Phe Asp Lys Ser Leu Ala 
                805                 810                 815     


Glu Asn Ala Ala Asn Arg Tyr Leu Arg Asn Ala Arg Trp Tyr Lys Leu 
            820                 825                 830         


Ile Leu Asp Asn Leu Lys Lys Ser Glu Arg Ala Val Val Thr Glu Phe 
        835                 840                 845             


Arg Asn Thr Val Cys His Leu Asn Ala Ile Arg Asn Ile Asn Ile Asn 
    850                 855                 860                 


Ile Lys Glu Ile Lys Glu Val Glu Asn Tyr Phe Ala Leu Tyr His Tyr 
865                 870                 875                 880 


Leu Ile Gln Lys His Leu Glu Asn Arg Phe Ala Asp Lys Lys Val Glu 
                885                 890                 895     


Arg Asp Thr Gly Asp Phe Ile Ser Lys Leu Glu Glu His Lys Thr Tyr 
            900                 905                 910         


Cys Lys Asp Phe Val Lys Ala Tyr Cys Thr Pro Phe Gly Tyr Asn Leu 
        915                 920                 925             


Val Arg Tyr Lys Asn Leu Thr Ile Asp Gly Leu Phe Asp Lys Asn Tyr 
    930                 935                 940                 


Pro Gly Lys Asp Asp Ser Asp Lys Gln Lys 
945                 950                 


<210>  3012
<211>  918
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3012

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Gly Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Asn Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp 
    370                 375                 380                 


Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ser 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Lys Val Ala Lys Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Arg Arg Leu Arg 
785                 790                 795                 800 


Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr Arg 
                805                 810                 815     


Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu Lys 
            820                 825                 830         


Glu Tyr Ile Gly Asp Ile Cys Thr Val Asp Ser Tyr Phe Ser Ile Tyr 
        835                 840                 845             


His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr Lys 
    850                 855                 860                 


Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His Gly 
865                 870                 875                 880 


Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr Asn 
                885                 890                 895     


Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg Asn 
            900                 905                 910         


Glu Tyr Leu Thr Glu Lys 
        915             


<210>  3013
<211>  918
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3013

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Gly Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Asn Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp 
    370                 375                 380                 


Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Gly Val Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ser Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu Arg 
785                 790                 795                 800 


Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr Arg 
                805                 810                 815     


Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu Lys 
            820                 825                 830         


Glu Tyr Ile Gly Asp Ile Cys Thr Val Asp Ser Tyr Phe Ser Ile Tyr 
        835                 840                 845             


His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr Lys 
    850                 855                 860                 


Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His Gly 
865                 870                 875                 880 


Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr Asn 
                885                 890                 895     


Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg Asn 
            900                 905                 910         


Glu Tyr Leu Thr Glu Lys 
        915             


<210>  3014
<211>  923
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3014

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Val Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Lys Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asp Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asp Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Lys Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Asn Ala 
            260                 265                 270         


Leu Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu His Glu 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Ile Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Asp Asp Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile 
        355                 360                 365             


Val Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg 
    370                 375                 380                 


Glu Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe 
                405                 410                 415     


Cys Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg 
            420                 425                 430         


Lys Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala 
        435                 440                 445             


Asp Glu Ala Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn 
    450                 455                 460                 


Ile Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala 
465                 470                 475                 480 


Asp Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala 
                485                 490                 495     


Ser Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe 
            500                 505                 510         


Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys 
        515                 520                 525             


Phe Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val 
    530                 535                 540                 


Asp Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser 
545                 550                 555                 560 


Gln Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met 
                565                 570                 575     


Arg Lys Pro Ala Ser Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu 
            580                 585                 590         


Thr Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu 
        595                 600                 605             


Ile Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn 
    610                 615                 620                 


Phe Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile 
625                 630                 635                 640 


Lys Tyr Ala Asn Ala Gln Lys Ile Arg Lys Val Ala Lys Asn Glu Lys 
                645                 650                 655     


Val Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg 
            660                 665                 670         


Tyr Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu 
        675                 680                 685             


Val Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp 
    690                 695                 700                 


Asp Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala 
705                 710                 715                 720 


Lys Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr 
                725                 730                 735     


Leu Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala 
            740                 745                 750         


Ile His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro 
        755                 760                 765             


Glu Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln 
    770                 775                 780                 


Thr Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys 
785                 790                 795                 800 


Asn Arg Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp 
                805                 810                 815     


Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val 
            820                 825                 830         


Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser 
        835                 840                 845             


Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg 
    850                 855                 860                 


Glu Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu 
865                 870                 875                 880 


Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser 
                885                 890                 895     


Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln 
            900                 905                 910         


Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920             


<210>  3015
<211>  921
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3015

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Met Lys 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Asp Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Lys Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Arg Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Asn Arg Val Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asn Asn Ile Tyr Pro Glu Tyr Arg Asp Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Pro 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp 
    370                 375                 380                 


Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Val Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Lys Val Ala Glu Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Ala Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn Lys 
785                 790                 795                 800 


Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Asn 
                805                 810                 815     


Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg 
            820                 825                 830         


Glu Leu Asn Lys Tyr Ile Lys Asp Ile Arg Thr Val Asp Ser Tyr Phe 
        835                 840                 845             


Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp 
    850                 855                 860                 


Asp Lys Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys 
865                 870                 875                 880 


Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe 
                885                 890                 895     


Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe 
            900                 905                 910         


Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920     


<210>  3016
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3016

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Ile Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Pro Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn His Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3017
<211>  918
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3017

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Gly Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Asn Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp 
    370                 375                 380                 


Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Gly Val Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ser Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu Arg 
785                 790                 795                 800 


Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr Arg 
                805                 810                 815     


Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu Lys 
            820                 825                 830         


Glu Tyr Ile Gly Asp Ile Cys Thr Val Asp Ser Tyr Phe Ser Ile Tyr 
        835                 840                 845             


His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr Lys 
    850                 855                 860                 


Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His Gly 
865                 870                 875                 880 


Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr Asn 
                885                 890                 895     


Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg Asn 
            900                 905                 910         


Glu Tyr Leu Thr Glu Lys 
        915             


<210>  3018
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3018

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asp Asn Asp Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asn 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Ser Val Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Gln Asn Thr Tyr Tyr Ile 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val 
            260                 265                 270         


Ser Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu 
    290                 295                 300                 


Tyr Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Val Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Ile Ala Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Leu Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3019
<211>  918
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3019

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Gly Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Asn Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Gly Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp 
    370                 375                 380                 


Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Gly Val Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ser Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu Arg 
785                 790                 795                 800 


Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr Arg 
                805                 810                 815     


Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu Lys 
            820                 825                 830         


Glu Tyr Ile Gly Asp Ile Cys Thr Val Asp Ser Tyr Phe Ser Ile Tyr 
        835                 840                 845             


His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr Lys 
    850                 855                 860                 


Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His Gly 
865                 870                 875                 880 


Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr Asn 
                885                 890                 895     


Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg Asn 
            900                 905                 910         


Glu Tyr Leu Thr Glu Lys 
        915             


<210>  3020
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3020

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Ile Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Ile Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Gly Val Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ser Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Cys Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  3021
<211>  1141
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3021

Met Gly Val Glu Lys Asn Lys Val Phe Glu Ser Val Ile Met Asn Phe 
1               5                   10                  15      


Asp Gln Glu Arg Lys Tyr Gly Phe Ile Glu Tyr Lys Glu Thr Asn Asn 
            20                  25                  30          


Leu Phe Phe His Met Glu Asn Val Lys Asn Pro Lys Glu Ile Val Lys 
        35                  40                  45              


Gly Ala Lys Val Arg Phe Glu Ile Tyr Glu Asn Pro Lys Pro Lys Lys 
    50                  55                  60                  


Gln Asn Gln Arg Phe Ser Ala Ile Asn Val Glu Val Ile Thr Asp Glu 
65                  70                  75                  80  


Thr His Lys Glu Ala Lys Ile Gln Lys Asn Glu Phe Lys Thr Phe Asp 
                85                  90                  95      


Gln Phe Thr Lys Glu Leu Gln Glu Thr Gln Lys Val Asn Gly Glu Thr 
            100                 105                 110         


Lys Lys Glu His Ile Thr Lys Asn Lys His Thr Asn Val Lys Ala Ala 
        115                 120                 125             


Gly Val Lys Ser Val Phe Ala Val Asp Asp Gly Asn Val Leu Ile Thr 
    130                 135                 140                 


Ser Phe Gly Arg Gly Asn Ala Ala Asp Ile Glu Thr Leu Lys Ser Asp 
145                 150                 155                 160 


Asp Asp Lys Thr Ile Asn Leu Thr Glu Thr Glu Asn Gln Lys Lys Tyr 
                165                 170                 175     


Val Val Thr Asn Lys Arg Ser Asn Val Lys Gly Leu Ala Asp Asn Pro 
            180                 185                 190         


Thr Lys Val Glu Ser Ile Ile Pro Gly Glu Thr Gln Ile Gly Phe Lys 
        195                 200                 205             


Ser Ile Leu Glu Lys His Phe Phe Gly Arg Thr Phe Asn Asp Asn Ile 
    210                 215                 220                 


His Ile Gln Ile Ile His Asn Ile Leu Asp Ile Lys Lys Ile Leu Ala 
225                 230                 235                 240 


Val His Thr Asn Asn Ile Val Tyr Ala Leu Asp Asn Ile His Glu Arg 
                245                 250                 255     


Gly Arg Glu Asn Ser Ala Glu Lys Pro Ile Asp Met Ile Gly Ala Gly 
            260                 265                 270         


Gly Ile Ser Thr Ser Lys Glu Tyr Glu Gln Tyr Cys Ser Glu Lys Ser 
        275                 280                 285             


Asp Tyr Glu Asp Asn Phe Leu Lys Gln Leu Ile Asn Asn Glu Arg Ile 
    290                 295                 300                 


Ala Tyr Phe Gly Asn Ala Phe Phe Lys Asp Glu Gly Asn Lys Lys Val 
305                 310                 315                 320 


Met Arg Thr Glu Lys Glu Ile Tyr Tyr Ile Leu Gly Met Leu Asn Glu 
                325                 330                 335     


Val Arg Asn Val Ser Thr His Phe Thr Glu Glu Asp Asn Arg Asp Trp 
            340                 345                 350         


Ala Lys Ala Asn Leu Tyr Asn Leu Ser Asn Arg Leu Lys Val Gly Ser 
        355                 360                 365             


Lys Glu Val Leu Asn Gln Leu Tyr Lys Glu Lys Ile Asp Lys Ile Asp 
    370                 375                 380                 


Ala Asn Gly Phe Val Asn Lys Gly Cys Lys Arg Asp Phe Ser Ile Leu 
385                 390                 395                 400 


Phe Lys Ser Leu Asn Leu Thr Thr Asp Lys Asp Lys Gly Glu Leu Val 
                405                 410                 415     


Val Gly Phe Tyr Asp Phe Ser Ile Arg Lys Asn Tyr Lys Asn Ile Gly 
            420                 425                 430         


Phe Ser Ile Lys Thr Leu Arg Glu Tyr Met Leu Lys Ile Ser Asn Ser 
        435                 440                 445             


Thr Leu Cys Ala Asp Thr Ile Ser Asn Asn Ala Ile Arg Pro Lys Ala 
    450                 455                 460                 


Tyr Lys Leu Tyr Asp Phe Ile Ile Trp His Tyr Tyr Met Asn Lys Pro 
465                 470                 475                 480 


Asp Lys Ile Asn Asp Phe Val Glu Lys Leu Arg Thr Gln Asn Lys Asn 
                485                 490                 495     


Asp Glu Lys Ile Lys Leu Tyr Tyr Asp Glu Ala Val Cys Leu Leu Ser 
            500                 505                 510         


Glu Leu Gly Arg Glu Ile His Thr Met Thr Ser Cys Val His Asn Ile 
        515                 520                 525             


Glu Asn Thr Ser Tyr Glu Ile Thr Asp Lys Lys Gln Lys Glu Tyr Tyr 
    530                 535                 540                 


Lys Met Gln Ile Asn Ser Leu Asn Ser Ala Asp Lys Val Ser Asp Phe 
545                 550                 555                 560 


Ser Lys Val Ile Tyr Leu Val Thr Leu Phe Leu Asp Gly Lys Glu Ile 
                565                 570                 575     


Asn Asp Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp Asn Ile Ala Ser 
            580                 585                 590         


Leu Leu Ser Val Leu Glu Lys Gln Ser Gly Lys Lys Val Glu Phe Val 
        595                 600                 605             


Glu Asn Tyr Ser Phe Phe Asn Ser Ser Asn Leu Leu Lys Glu Lys Thr 
    610                 615                 620                 


Leu Asn Lys Ser Glu Asn Tyr Thr Cys Lys Ile Val Glu Glu Leu Arg 
625                 630                 635                 640 


Glu Ile Asn Ser Phe Ala Arg Met Thr Gly Asp Cys Lys Ile Arg Lys 
                645                 650                 655     


Ser Ala Phe Glu Asp Ala Ser Gln Leu Leu Gly Tyr His Asp Lys Thr 
            660                 665                 670         


Val Asn Asn Leu Phe Glu Val Leu Arg Leu Lys Glu Leu Glu Ser Lys 
        675                 680                 685             


Asp Trp Lys Lys Arg Thr Asp Asp Glu Gln Gln Glu Tyr Asp Arg Leu 
    690                 695                 700                 


Leu Asn Lys His His Tyr Phe Lys Ser Gly Lys Lys Leu Pro Asp Thr 
705                 710                 715                 720 


Gly Leu Arg Asn Phe Ile Ile Asn Asn Val Ile Glu Ser Arg Arg Phe 
                725                 730                 735     


Asn Tyr Ile Val Arg Tyr Ala Asp Pro Lys Lys Ile Arg Lys Cys Thr 
            740                 745                 750         


Glu Asn Asn Glu Leu Leu Lys Phe Ala Phe Lys Asp Val Pro Asp Ser 
        755                 760                 765             


Gln Val Asp Arg Tyr Tyr Asn Ile Cys Val Thr Asn Lys Ile Thr Asn 
    770                 775                 780                 


Ala Thr Arg Glu Glu Lys Ile Glu Arg Leu Val Asp Ile Ile Lys Ser 
785                 790                 795                 800 


Met Asn Leu Ser Lys Val Ala Thr Val Lys Gln Arg Asp Lys Gln Asp 
                805                 810                 815     


Asn Val Glu Lys Gln Lys Gln Leu Ala Ile Met Ser Leu Tyr Leu Asn 
            820                 825                 830         


Ile Leu Tyr Gln Ile Ala Lys Asn Leu Val Tyr Val Asn Ser Arg Tyr 
        835                 840                 845             


Val Met Ala Phe His Ser Leu Glu Arg Asp Ser Gln Met Leu Phe Asp 
    850                 855                 860                 


Ala Tyr Tyr Asp Val Lys Arg Gly Tyr Cys Asp Leu Ser Thr Val Leu 
865                 870                 875                 880 


Leu Phe Gly Val Asp Asp Leu Gln Asn Arg Asn Arg Gly Ser Tyr Lys 
                885                 890                 895     


Tyr Leu Arg Asp Asn Arg Arg Ser Asn Lys Asp Val Ile Glu Thr Phe 
            900                 905                 910         


Gly Asp Phe Lys Gly Lys Val Ser Lys Val Val Glu Lys Lys Asn Gln 
        915                 920                 925             


Gly Leu Thr Asn Glu Ile Tyr Asp Ser Leu Cys Asn Val Ala Gly Thr 
    930                 935                 940                 


Thr Lys Thr Glu Val Gln Asn Glu Ile Lys Ser Ile Leu Lys Ser Asn 
945                 950                 955                 960 


Gly Leu Asp Glu Ser Ala Ser Ser Tyr Leu Ser His Lys Leu Val Asn 
                965                 970                 975     


Lys Val His Ser Tyr Lys Tyr Leu Lys Gln Asn Leu Asp Cys Ala Asp 
            980                 985                 990         


Asn Thr Met Ile Asn Gln Phe Arg  Asn Asn Val Ala His  Leu Asn Thr 
        995                 1000                 1005             


Ile Arg  Asn Met Asp Gly Ile  Glu Asn Val Thr Gly  Ile Thr Ser 
    1010                 1015                 1020             


Tyr Phe  Gln Ile Tyr His Tyr  Leu Met Gln Lys Ala  Leu Tyr Lys 
    1025                 1030                 1035             


Glu Phe  Lys Lys Cys Arg Glu  Asn Ala Val Arg Lys  Trp Ile Pro 
    1040                 1045                 1050             


Tyr Ile  Thr Glu Asn Ala Glu  Pro Lys Tyr Val Tyr  Trp Asn Lys 
    1055                 1060                 1065             


Lys Glu  Gln Gln Glu Val Glu  Val Ser Phe Asn Pro  Lys Ile Phe 
    1070                 1075                 1080             


Gly Tyr  Met Glu Asn Ile Lys  Asn His Ser Asn Thr  Tyr Cys Lys 
    1085                 1090                 1095             


Asp Phe  Val Lys Ala Leu Cys  Ala Pro Phe Ala Tyr  Asn Leu Pro 
    1100                 1105                 1110             


Arg Phe  Lys Asn Leu Ser Ile  Glu Glu Leu Phe Asp  Met His Glu 
    1115                 1120                 1125             


Leu Ser  Glu Glu Pro Lys Glu  Ser Met Lys Leu Thr  Asp 
    1130                 1135                 1140     


<210>  3022
<211>  954
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3022

Met Gly Lys Lys Ile His Ala Arg Asp Leu Arg Glu Gln Arg Lys Thr 
1               5                   10                  15      


Asp Arg Thr Glu Lys Phe Ala Asp Gln Asn Lys Lys Arg Glu Ala Glu 
            20                  25                  30          


Arg Ala Val Gln Lys Lys Asp Ala Thr Val Ser Val Lys Ser Val Ser 
        35                  40                  45              


Ser Val Ser Ser Lys Lys Asp Asn Ala Thr Lys Ser Met Ala Lys Ala 
    50                  55                  60                  


Ala Gly Val Lys Ser Val Phe Ala Val Gly Asn Thr Val Tyr Met Thr 
65                  70                  75                  80  


Ser Phe Gly Arg Gly Asn Asp Ala Val Leu Glu Gln Lys Ile Val Asp 
                85                  90                  95      


Thr Ser His Glu Pro Leu Asn Ile Asp Asp Pro Ala Tyr Gln Leu Asn 
            100                 105                 110         


Val Val Thr Met Asn Gly Tyr Ser Val Thr Gly His Arg Gly Glu Thr 
        115                 120                 125             


Val Ser Ala Val Thr Asp Asn Pro Leu Arg Arg Phe Asn Gly Gly Lys 
    130                 135                 140                 


Lys Asp Glu Pro Glu Gln Ser Val Pro Thr Asp Met Leu Cys Leu Lys 
145                 150                 155                 160 


Pro Thr Leu Glu Lys Lys Phe Phe Gly Lys Glu Phe Asn Asp Asn Ile 
                165                 170                 175     


His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala 
            180                 185                 190         


Val Tyr Ser Thr Asn Ala Ile Tyr Ala Leu Asn Asn Met Ser Ala Asp 
        195                 200                 205             


Glu Asn Ile Glu Asn Ser Asp Phe Phe Met Lys Arg Thr Thr Asp Glu 
    210                 215                 220                 


Thr Phe Asp Asp Phe Glu Lys Lys Lys Glu Ser Thr Asn Ser Arg Glu 
225                 230                 235                 240 


Lys Ala Asp Phe Asp Ala Phe Glu Lys Phe Ile Gly Asn Tyr Arg Leu 
                245                 250                 255     


Ala Tyr Phe Ala Asp Ala Phe Tyr Val Asn Lys Lys Asn Pro Lys Gly 
            260                 265                 270         


Lys Ala Arg Asn Val Leu Arg Glu Asp Lys Glu Leu Tyr Ser Val Leu 
        275                 280                 285             


Thr Leu Ile Gly Lys Leu Arg His Trp Cys Val His Ser Glu Glu Gly 
    290                 295                 300                 


Arg Ala Glu Phe Trp Leu Tyr Lys Leu Asp Glu Leu Lys Asp Asp Phe 
305                 310                 315                 320 


Lys Asn Val Leu Asp Val Val Tyr Asn Arg Pro Val Glu Glu Ile Asn 
                325                 330                 335     


Asn Arg Phe Ile Glu Asn Asn Lys Val Asn Ile Gln Ile Leu Gly Ser 
            340                 345                 350         


Val Tyr Lys Asn Thr Asp Ile Ala Glu Leu Val Arg Ser Tyr Tyr Glu 
        355                 360                 365             


Phe Leu Ile Thr Lys Lys Tyr Lys Asn Met Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Ser Met Leu Glu Gly Lys Gly Tyr Ala Asp Lys Glu Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Asn Lys Leu Tyr Gln Met Thr Asp Phe Ile Leu Tyr 
                405                 410                 415     


Thr Gly Tyr Ile Asn Glu Asp Ser Asp Arg Ala Asp Asp Leu Val Asn 
            420                 425                 430         


Thr Leu Arg Ser Ser Leu Lys Glu Asp Asp Lys Thr Thr Val Tyr Cys 
        435                 440                 445             


Lys Glu Ala Asp Tyr Leu Trp Lys Lys Tyr Arg Glu Ser Ile Arg Glu 
    450                 455                 460                 


Val Ala Asp Ala Leu Asp Gly Asp Asn Ile Lys Arg Leu Ser Lys Ser 
465                 470                 475                 480 


Asn Ile Glu Ile Gln Glu Asp Lys Leu Arg Lys Cys Phe Ile Ser Tyr 
                485                 490                 495     


Ala Asp Ser Val Ser Glu Phe Thr Lys Leu Ile Tyr Leu Leu Thr Arg 
            500                 505                 510         


Phe Leu Ser Gly Lys Glu Ile Asn Asp Leu Val Thr Thr Leu Ile Asn 
        515                 520                 525             


Lys Phe Asp Asn Ile Arg Ser Phe Leu Glu Ile Met Asp Glu Leu Gly 
    530                 535                 540                 


Leu Asp Arg Thr Phe Thr Ala Glu Tyr Ser Phe Phe Glu Gly Ser Thr 
545                 550                 555                 560 


Lys Tyr Leu Ala Glu Leu Val Glu Leu Asn Ser Phe Val Lys Ser Cys 
                565                 570                 575     


Ser Phe Asp Ile Asn Ala Lys Arg Thr Met Tyr Arg Asp Ala Leu Asp 
            580                 585                 590         


Ile Leu Gly Ile Lys Ser Gly Lys Thr Glu Glu Asp Ile Glu Lys Met 
        595                 600                 605             


Ile Asp Asn Ile Leu Gln Ile Asp Ala Asn Gly Asp Lys Lys Leu Lys 
    610                 615                 620                 


Lys Asn Asn Gly Leu Arg Asn Phe Ile Ala Ser Asn Val Ile Asp Ser 
625                 630                 635                 640 


Asn Arg Phe Lys Tyr Leu Val Arg Tyr Gly Asn Pro Lys Lys Ile Arg 
                645                 650                 655     


Glu Thr Ala Lys Cys Lys Pro Ala Val Arg Phe Val Leu Asn Glu Ile 
            660                 665                 670         


Pro Asp Ala Gln Ile Glu Arg Tyr Tyr Glu Ala Cys Cys Pro Glu Asn 
        675                 680                 685             


Thr Ala Leu Cys Ser Ala Asn Lys Lys Arg Glu Lys Leu Ala Asp Met 
    690                 695                 700                 


Ile Ala Glu Ile Glu Phe Glu Asn Phe Ser Asp Ala Gly Asn Tyr Gln 
705                 710                 715                 720 


Lys Ala Asn Val Thr Ser Lys Thr His Glu Ala Glu Ile Lys Arg Lys 
                725                 730                 735     


Asn Gln Ser Ile Ile Arg Leu Tyr Leu Thr Val Met Tyr Ile Met Leu 
            740                 745                 750         


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Phe His Cys 
        755                 760                 765             


Val Glu Arg Asp Thr Lys Leu Tyr Ala Glu Ser Gly Leu Glu Val Gly 
    770                 775                 780                 


Asn Ile Glu Lys Asn Lys Thr Asn Leu Thr Met Ala Val Met Gly Val 
785                 790                 795                 800 


Lys Leu Glu Asn Gly Ile Ile Lys Thr Glu Phe Asp Lys Ser Phe Ala 
                805                 810                 815     


Glu Asn Ala Ala Asn Arg Tyr Leu Arg Asn Ala Arg Trp Tyr Lys Leu 
            820                 825                 830         


Ile Leu Asp Asn Leu Lys Lys Ser Glu Arg Ala Val Val Asn Glu Phe 
        835                 840                 845             


Arg Asn Thr Val Cys His Leu Asn Ala Ile Arg Asn Ile Asn Ile Asn 
    850                 855                 860                 


Ile Asp Gly Ile Lys Glu Val Glu Asn Tyr Phe Ala Leu Tyr His Tyr 
865                 870                 875                 880 


Leu Ile Gln Lys His Leu Glu Asn Arg Phe Ala Asp Lys Lys Val Glu 
                885                 890                 895     


Arg Asp Thr Gly Asp Phe Ile Ser Lys Leu Glu Glu His Lys Thr Tyr 
            900                 905                 910         


Cys Lys Asp Phe Val Lys Ala Tyr Cys Thr Pro Phe Gly Tyr Asn Leu 
        915                 920                 925             


Val Arg Tyr Lys Asn Leu Thr Ile Asp Gly Leu Phe Asp Lys Asn Tyr 
    930                 935                 940                 


Pro Gly Lys Asp Asp Ser Asp Lys Gln Lys 
945                 950                 


<210>  3023
<211>  918
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3023

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Gly Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Asn Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp 
    370                 375                 380                 


Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Gly Val Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ser Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu Arg 
785                 790                 795                 800 


Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr Arg 
                805                 810                 815     


Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu Lys 
            820                 825                 830         


Glu Tyr Ile Gly Asp Ile Cys Thr Val Asp Ser Tyr Phe Ser Ile Tyr 
        835                 840                 845             


His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr Lys 
    850                 855                 860                 


Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His Gly 
865                 870                 875                 880 


Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr Asn 
                885                 890                 895     


Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg Asn 
            900                 905                 910         


Glu Tyr Leu Thr Glu Lys 
        915             


<210>  3024
<211>  918
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3024

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Gly Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Asn Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp 
    370                 375                 380                 


Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Gly Val Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ser Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu Arg 
785                 790                 795                 800 


Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr Arg 
                805                 810                 815     


Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu Lys 
            820                 825                 830         


Glu Tyr Ile Gly Asp Ile Cys Thr Val Asp Ser Tyr Phe Ser Ile Tyr 
        835                 840                 845             


His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr Lys 
    850                 855                 860                 


Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His Gly 
865                 870                 875                 880 


Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr Asn 
                885                 890                 895     


Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg Asn 
            900                 905                 910         


Glu Tyr Leu Thr Glu Lys 
        915             


<210>  3025
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3025

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Gln Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Ser Val Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Gln Asn Thr Tyr Tyr Ile 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val 
            260                 265                 270         


Ser Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu 
    290                 295                 300                 


Tyr Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Val Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Ile Ala Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Leu Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Asn Arg Asp Glu Ser Pro Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asp Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  3026
<211>  981
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3026

Val Glu Lys Arg Leu Asn Glu Ser Leu Gln Lys Gln Arg Glu Gln Gln 
1               5                   10                  15      


Thr Val Thr Asp Glu Ser Glu Arg Lys Lys Lys Pro Leu Lys Ser Gly 
            20                  25                  30          


Ala Lys Ala Ala Gly Leu Lys Ser Val Phe Val Leu Ser Glu Gly Lys 
        35                  40                  45              


Glu Leu Leu Thr Ser Phe Gly Arg Gly Asn Glu Ala Val Pro Glu Lys 
    50                  55                  60                  


Arg Val Thr Gly Gly Thr Ile Ala Asn Ala Arg Thr Asp Asn Lys Glu 
65                  70                  75                  80  


Ala Phe Ser Ala Ala Leu Gln Asn Lys Arg Phe Glu Val Phe Gly Arg 
                85                  90                  95      


Thr Ala Gly Ser Ser Asp Asp Pro Leu Ala Val Ser Arg Ala Pro Gly 
            100                 105                 110         


Gln Asp Leu Ile Gly Ala Lys Thr Ala Leu Glu Glu Arg Tyr Phe Gly 
        115                 120                 125             


Arg Ala Phe Ala Asp Asn Ile His Met Gln Val Ile Tyr Ala Ile Gln 
    130                 135                 140                 


Asp Ile Asn Lys Ile Leu Ala Val His Ala Asn Asn Ile Val Tyr Thr 
145                 150                 155                 160 


Leu Asn Asn Leu Asp Arg Glu Ala Asp Pro Glu Thr Asp Asp Phe Ile 
                165                 170                 175     


Gly Ser Gly Tyr Leu Thr Leu Lys Asn Thr Phe Glu Thr Tyr Cys Asp 
            180                 185                 190         


Pro Ala Ala Leu Asn Glu Arg Glu Arg Glu Lys Val Thr Val Ser Lys 
        195                 200                 205             


Gln His Phe Asp Ala Phe Met Gln Asn Pro Arg Leu Ala Tyr Tyr Gly 
    210                 215                 220                 


Asn Ala Phe Phe Arg Lys Leu Ser Lys Ala Glu Arg Leu Ala Arg Gly 
225                 230                 235                 240 


Arg Glu Ile Phe Asp Lys Glu Ser Pro Glu Arg Arg Gln Glu Ile Leu 
                245                 250                 255     


Gly Ser Arg Gly Lys Asn Lys Ser Val Asp Asp Glu Ile Arg Ala Leu 
            260                 265                 270         


Ala Pro Glu Trp Val Lys Arg Glu Glu Arg Asp Val Tyr Ser Glu Leu 
        275                 280                 285             


Val Leu Met Ser Glu Leu Arg Gln Ser Cys Phe His Gly Gln Gln Lys 
    290                 295                 300                 


Asn Ser Ala Arg Ile Phe Arg Leu Asp Asn Asp Leu Gly Pro Gly Val 
305                 310                 315                 320 


Asp Gly Ala Arg Glu Leu Leu Asp Arg Leu Tyr Ala Glu Lys Ile Asn 
                325                 330                 335     


Asp Leu Arg Ser Phe Asp Lys Thr Ser Ala Ser Ser Asn Phe Arg Leu 
            340                 345                 350         


Leu Phe Asn Ala Tyr His Ala Asp Asn Glu Lys Lys Lys Glu Leu Ala 
        355                 360                 365             


Gln Glu Phe Tyr Arg Phe Ser Val Leu Lys Val Ser Lys Asn Thr Gly 
    370                 375                 380                 


Phe Ser Ile Arg Thr Leu Arg Glu Lys Ile Ile Glu Asp His Ala Ala 
385                 390                 395                 400 


Gln Tyr Arg Asp Lys Ile Tyr Asp Ser Met Arg Lys Lys Leu Phe Ser 
                405                 410                 415     


Thr Phe Asp Phe Phe Leu Trp Arg Phe Tyr Glu Glu Arg Glu Asp Glu 
            420                 425                 430         


Ala Glu Glu Leu Arg Ala Cys Leu Arg Ala Ala Arg Ser Asp Glu Glu 
        435                 440                 445             


Lys Glu Gln Ile Tyr Ala Glu Ala Ala Ala Ser Cys Trp Pro Ser Val 
    450                 455                 460                 


Lys Pro Phe Val Glu Ser Val Ala Ala Thr Leu Cys Asp Val Val Lys 
465                 470                 475                 480 


Gly Arg Thr Lys Leu Asn Lys Leu Lys Leu Ser Ala Asp Glu Ser Thr 
                485                 490                 495     


Leu Val Arg Asn Ala Ile Asp Gly Val Arg Ile Ser Pro Arg Ala Ser 
            500                 505                 510         


Tyr Phe Thr Lys Leu Ile Tyr Leu Met Thr Leu Phe Leu Asp Gly Lys 
        515                 520                 525             


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile His Ala Phe Glu Asn Ile 
    530                 535                 540                 


Asp Ser Phe Leu Ser Val Leu Gly Ser Glu Arg Leu Glu Arg Thr Phe 
545                 550                 555                 560 


Asp Ala Asn Tyr Arg Ile Phe Ala Asp Ser Gly Val Ile Ala Gln Glu 
                565                 570                 575     


Leu Arg Ala Val Asn Ser Phe Ala Arg Met Thr Thr Glu Pro Phe Asn 
            580                 585                 590         


Ser Lys Leu Val Met Phe Glu Asp Ala Ala Gln Leu Phe Gly Met Ser 
        595                 600                 605             


Gly Gly Leu Val Glu His Ala Glu Glu Leu Arg Glu Tyr Leu Asp Asn 
    610                 615                 620                 


Lys Met Leu Asp Lys Thr Lys Leu Arg Leu Leu Pro Asp Gly Lys Val 
625                 630                 635                 640 


Asp Thr Gly Phe Arg Asn Phe Ile Ile Ser Asn Val Thr Glu Ser Arg 
                645                 650                 655     


Arg Phe Arg Tyr Leu Val Arg Tyr Cys Glu Pro Arg Ala Val Arg Asp 
            660                 665                 670         


Tyr Met Ser Cys Arg Pro Leu Ile Arg Leu Thr Leu Arg Asp Met Pro 
        675                 680                 685             


Asp Thr Ile Leu Arg Arg Tyr Tyr Glu Gln Ser Val Gly Ala Ala Thr 
    690                 695                 700                 


Val Asp Arg Glu Arg Ile Leu Asp Thr Leu Ala Asp Lys Leu Leu Ser 
705                 710                 715                 720 


Leu Arg Phe Thr Asp Phe Glu Asn Val Asn Gln Arg Ala Asn Ala Glu 
                725                 730                 735     


Arg Asn Arg Glu Lys Gln Lys Met Met Gly Ile Ile Ser Leu Tyr Leu 
            740                 745                 750         


Asn Val Ala Tyr Gln Ile Val Lys Asn Leu Val Tyr Val Asn Ala Arg 
        755                 760                 765             


Tyr Thr Met Ala Tyr His Cys Ala Glu Arg Asp Thr Glu Leu Leu Leu 
    770                 775                 780                 


Asn Ala Ala Gly Glu Gly Asn Leu Leu Arg Arg Asp Arg Ser Trp Pro 
785                 790                 795                 800 


Ala Arg Leu His Leu Pro Arg Arg Ala Leu Ala Arg Arg Arg Asp Arg 
                805                 810                 815     


Val Glu Val Met Glu Arg Asp Val Ala Arg Gly Pro Glu Ala Tyr Asn 
            820                 825                 830         


Arg Asp Glu Trp Leu Gly Leu Val Arg Thr Leu Arg Arg Glu Lys Arg 
        835                 840                 845             


Val Cys Asp Asn Leu His Asn Asn Tyr Ala Tyr Leu Cys Gly Ala Asp 
    850                 855                 860                 


Ala Glu Pro Gly Asp Ala Ser Leu Ser Leu Leu Phe Val Tyr Arg Asn 
865                 870                 875                 880 


Lys Ala Ala His Leu Ser Val Leu Asn Lys Gly Gly Arg Leu Ser Gly 
                885                 890                 895     


Asp Leu Lys Glu Ala Lys Ser Trp Phe Tyr Val Tyr His Phe Leu Met 
            900                 905                 910         


Gln Arg Val Leu Glu Glu Glu Phe Arg Asn Thr Gln Ala Leu Pro Glu 
        915                 920                 925             


Arg Leu Arg Glu Leu Leu Met Met Ala Glu Arg Tyr Arg Gly Cys Ser 
    930                 935                 940                 


Lys Asp Leu Ile Lys Val Leu Asn Leu Thr Phe Ala Tyr Asn Leu Pro 
945                 950                 955                 960 


Arg Tyr Lys Asn Leu Ser Ile Asp Gly Arg Phe Asp Lys Asn His Pro 
                965                 970                 975     


Asp Pro Ser Asp Glu 
            980     


<210>  3027
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3027

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Asp Gly Ser Ser Asn Ile Glu Leu Arg Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Gln Asn Thr Tyr Tyr Ile Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu Tyr Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Val Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Glu 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Pro Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp Asp Ile 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  3028
<211>  960
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3028

Met Ala Lys Lys Leu Asn Ala Lys Glu Lys Arg Leu Leu Ser Gln Gln 
1               5                   10                  15      


Ala Gln Lys Asp Lys Tyr Lys Lys Met Glu Glu Glu Arg Gln Ala Ala 
            20                  25                  30          


Glu Gln Ala Arg Leu Ala Glu Glu Ala Arg Gln Lys Ala Glu Thr Glu 
        35                  40                  45              


Arg Lys Lys Lys Glu Ala Leu Glu Lys Glu Ala Arg Glu Lys Leu Glu 
    50                  55                  60                  


Lys Glu Leu Leu Glu Lys Asn Pro Ser Leu Lys Lys Val Lys Lys Ser 
65                  70                  75                  80  


Lys Ala Lys Ala Ala Gly Leu Lys Ser Thr Phe Ala Ile Gly Asn Glu 
                85                  90                  95      


Leu Leu Met Thr Ser Phe Gly Lys Gly Asn Glu Ala Val Pro Glu His 
            100                 105                 110         


Tyr Ile Phe Glu Asn Gly Met Ile Ser Met Gln Asn Pro Pro Ala Phe 
        115                 120                 125             


Asp Val Glu Asn Arg Gly Thr Ser Phe Ser Ile Ala Gly Lys Asn Ala 
    130                 135                 140                 


Met Asn Ala Ile Ala Asp Asp Pro Arg Arg Thr Ser Lys Lys Val Ile 
145                 150                 155                 160 


Gly Glu Asp Leu Ile Gly Ala Lys Ser Ala Leu Glu Lys Arg Tyr Phe 
                165                 170                 175     


Gly Lys Thr Phe Glu Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
            180                 185                 190         


Leu Asp Ile Glu Lys Ile Leu Ser Lys His Ile Asn Asn Ile Val Phe 
        195                 200                 205             


Ser Ile Asn Asn Ile Arg Gly Ile Ala Asp Pro Glu Arg Asp Asp Leu 
    210                 215                 220                 


Ile Gly Tyr Met Ser Leu Arg Asp Ser Tyr Glu Tyr Phe Met Asp Glu 
225                 230                 235                 240 


Lys Asn Glu Lys Arg Lys Val Leu Arg Glu Ser Tyr Arg Lys Leu Phe 
                245                 250                 255     


Lys Ser Ser Arg Leu Ser Tyr Phe Gly Ser Ala Phe Tyr Val Glu Lys 
            260                 265                 270         


Gln Ser Thr Gln Lys Lys Lys Ser Gly Gln Lys Asn Phe Glu Leu Arg 
        275                 280                 285             


Asn Glu Lys Asp Cys Tyr Tyr Met Leu Ala Leu Leu Gly Glu Leu Arg 
    290                 295                 300                 


Gln Val Leu Ala His Ser Ser Ala Gln Lys Gln Gly Lys Glu Gln Thr 
305                 310                 315                 320 


Glu Ala Arg Ser Ser Val Tyr Asn Leu Arg Thr Val Gly Asn Asn Asp 
                325                 330                 335     


Met Arg Lys Ile Leu Asn Ser Leu Tyr Ala Glu Arg Val Asp Ala Leu 
            340                 345                 350         


Asn Glu Asn Phe Met Asn Tyr Ala Lys Lys Asp Leu Thr Ile Leu Phe 
        355                 360                 365             


Gly Ile Met Asp Ala Ser Ser Tyr Glu Lys Lys Ala Glu Ile Ala Arg 
    370                 375                 380                 


Asp Phe Tyr Asp Phe Thr Val Arg Lys Ser Tyr Lys Asn Ile Gly Phe 
385                 390                 395                 400 


Ser Ile Lys Lys Ile Arg Glu Arg Met Met Asp Cys Phe Phe Ala Asn 
                405                 410                 415     


Val Lys Glu Ile Thr Pro Asp Ser Pro Asp Phe Gln Ser Val Arg Gln 
            420                 425                 430         


Lys Phe Tyr Lys Ile Leu Asp Phe Leu Leu Phe Thr Tyr Tyr Lys Asp 
        435                 440                 445             


Asn Lys Glu Glu Thr Lys Lys Ile Ile Ala Ala Leu Arg Ala Ser Leu 
    450                 455                 460                 


Thr Glu Leu Glu Lys Glu Leu Phe Tyr Gln Lys Gln Ala Asn Ile Leu 
465                 470                 475                 480 


Trp Asn Lys Met Gln Met Val Val Thr Glu Gln Ile Tyr Pro Arg Thr 
                485                 490                 495     


Lys Gly Ser Ala Ile Gln Asn Leu Ile Ala Asp Pro Glu Ile Ser Ala 
            500                 505                 510         


Asp Met Leu Lys Gly Val Met Ile Thr Pro Glu Ser Val Asp Tyr Phe 
        515                 520                 525             


Ser Lys Met Ile Tyr Leu Leu Thr Leu Phe Ile Asp Gly Lys Glu Ile 
    530                 535                 540                 


Asn Asp Leu Leu Thr Thr Met Ile Asn Lys Phe Glu Asn Ile Ala Ser 
545                 550                 555                 560 


Phe Val Ser Val Leu Lys Asp Arg Gly Leu Pro Cys Asn Phe Arg Asn 
                565                 570                 575     


Asp Tyr Ser Val Phe Asn Asn Ala Leu Lys Ile Ser Ala Glu Leu Arg 
            580                 585                 590         


Glu Ile Asn Ser Phe Ala Arg Met Glu Lys Ala Thr Pro Gly Ala Lys 
        595                 600                 605             


Lys Gln Met Phe Leu Asp Ala Ala Ile Ile Leu Gly Ser Asn Glu Ser 
    610                 615                 620                 


Ala Glu Glu Leu Ser Glu Tyr Phe Asp Glu Met Leu Asp Lys Gln Lys 
625                 630                 635                 640 


Gly Lys Arg Thr Pro Gly Gly Lys Lys Asp Met Gly Phe Arg Asn Phe 
                645                 650                 655     


Leu Ile Lys Asn Val Ile Glu Ser Asp Arg Phe His Tyr Leu Ile Arg 
            660                 665                 670         


Tyr Gly His Pro Leu His Ile Arg Lys Leu Ala Glu Asn Lys Asn Val 
        675                 680                 685             


Ile Ala Phe Val Leu Lys Gln Ile Pro Glu Pro Gln Ile Asp Arg Tyr 
    690                 695                 700                 


Cys Lys Ile Cys Ala Leu Pro Ala Glu Ser Asn Phe Ala Gln Lys Ile 
705                 710                 715                 720 


Leu Arg Leu Thr Asp Leu Ile Ala Glu Met Asn Phe Arg Gln Phe Glu 
                725                 730                 735     


Asn Val Arg Gln Thr Glu Lys Asn Glu Gln Lys Gln Ile Leu Gln Gly 
            740                 745                 750         


Ile Leu Ser Leu Tyr Leu Thr Val Leu Tyr Leu Leu Thr Lys Asn Leu 
        755                 760                 765             


Val Tyr Val Asn Ser Arg Tyr Phe Leu Ala Phe His Cys Leu Glu Arg 
    770                 775                 780                 


Asp Thr Glu Leu Leu Gly Ser Gln Ala Gly His Lys Asn Ala Glu Lys 
785                 790                 795                 800 


Gln Leu Ile Ala Ser Tyr Ser Ala Leu Thr Gln Gln Phe Leu Asp Glu 
                805                 810                 815     


Gly Lys Leu Asn Arg His Ala Arg Glu Tyr Leu Thr Val Asn Ile Gln 
            820                 825                 830         


Asn Ser Asp Asp Trp Thr Ile Ala Gln Tyr Arg Asn Asn Ala Ala His 
        835                 840                 845             


Leu Asn Ala Ile Arg Asn Ala His Leu Tyr Ile Arg Glu Met Lys Ser 
    850                 855                 860                 


Val Arg Ser Tyr Phe Glu Leu Tyr His Tyr Leu Thr Gln Arg Ala Leu 
865                 870                 875                 880 


Leu Asp Lys Tyr Glu Asn Val Pro Tyr His Pro Gln Val Asn Glu Lys 
                885                 890                 895     


Thr Leu Lys Tyr Phe Glu Leu Leu Lys Glu Asn Gly Trp Tyr Cys Lys 
            900                 905                 910         


Asp Phe Val Lys Ala Leu Asn Val Pro Phe Gly Tyr Asn Leu Pro Arg 
        915                 920                 925             


Tyr Lys Asn Leu Ser Ile Asp Ala Leu Phe Asp Lys Asp Arg Pro Gln 
    930                 935                 940                 


Glu Glu Asp Glu Asn His Leu Tyr Thr Cys Gln Asn Ile Lys Lys Ser 
945                 950                 955                 960 


<210>  3029
<211>  960
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3029

Met Ala Lys Lys Leu Asn Ala Lys Glu Lys Arg Leu Leu Ser Gln Gln 
1               5                   10                  15      


Ala Gln Lys Asp Lys Tyr Lys Lys Met Glu Glu Glu Arg Gln Ala Ala 
            20                  25                  30          


Glu Gln Ala Arg Leu Ala Glu Glu Ala Arg Gln Lys Ala Glu Thr Glu 
        35                  40                  45              


Arg Lys Lys Lys Glu Ala Leu Glu Lys Glu Ala Arg Glu Lys Leu Glu 
    50                  55                  60                  


Lys Glu Leu Leu Glu Lys Asn Pro Ser Leu Lys Lys Val Lys Lys Ser 
65                  70                  75                  80  


Lys Ala Lys Ala Ala Gly Leu Lys Ser Thr Phe Ala Ile Gly Asn Glu 
                85                  90                  95      


Leu Leu Met Thr Ser Phe Gly Lys Gly Asn Glu Ala Val Pro Glu His 
            100                 105                 110         


Tyr Ile Phe Glu Asn Gly Met Ile Ser Met Gln Asn Pro Pro Ala Phe 
        115                 120                 125             


Asp Val Glu Asn Arg Gly Thr Ser Phe Ser Ile Ala Gly Lys Asn Ala 
    130                 135                 140                 


Met Asn Ala Ile Ala Asp Asp Pro Arg Arg Thr Ser Lys Lys Val Ile 
145                 150                 155                 160 


Gly Glu Asp Leu Ile Gly Ala Lys Ser Ala Leu Glu Lys Arg Tyr Phe 
                165                 170                 175     


Gly Lys Thr Phe Glu Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
            180                 185                 190         


Leu Asp Ile Glu Lys Ile Leu Ser Lys His Ile Asn Asn Ile Val Phe 
        195                 200                 205             


Ser Ile Asn Asn Ile Arg Gly Ile Ala Asp Pro Glu Arg Asp Asp Leu 
    210                 215                 220                 


Ile Gly Tyr Met Ser Leu Arg Asp Ser Tyr Glu Tyr Phe Met Asp Glu 
225                 230                 235                 240 


Lys Asn Glu Lys Arg Lys Val Leu Arg Glu Ser Tyr Arg Lys Leu Phe 
                245                 250                 255     


Lys Ser Ser Arg Leu Ser Tyr Phe Gly Ser Ala Phe Tyr Val Glu Lys 
            260                 265                 270         


Gln Ser Thr Gln Lys Lys Lys Ser Gly Gln Lys Asn Phe Glu Leu Arg 
        275                 280                 285             


Asn Glu Lys Asp Cys Tyr Tyr Met Leu Ala Leu Leu Gly Glu Leu Arg 
    290                 295                 300                 


Gln Val Leu Ala His Ser Ser Ala Gln Lys Gln Gly Lys Glu Gln Thr 
305                 310                 315                 320 


Glu Ala Arg Ser Ser Val Tyr Asn Leu Arg Thr Val Gly Asn Asn Asp 
                325                 330                 335     


Met Arg Lys Ile Leu Asn Ser Leu Tyr Ala Glu Arg Val Asp Ala Leu 
            340                 345                 350         


Asn Glu Asn Phe Met Asn Tyr Ala Lys Lys Asp Leu Thr Ile Leu Phe 
        355                 360                 365             


Gly Ile Met Asp Ala Ser Ser Tyr Glu Lys Lys Ala Glu Ile Ala Arg 
    370                 375                 380                 


Asp Phe Tyr Asp Phe Thr Val Arg Lys Ser Tyr Lys Asn Ile Gly Phe 
385                 390                 395                 400 


Ser Ile Lys Lys Ile Arg Glu Arg Met Met Asp Cys Phe Phe Ala Asn 
                405                 410                 415     


Val Lys Glu Ile Thr Pro Asp Ser Pro Asp Phe Gln Ser Val Arg Gln 
            420                 425                 430         


Lys Phe Tyr Lys Ile Leu Asp Phe Leu Leu Phe Thr Tyr Tyr Lys Asp 
        435                 440                 445             


Asn Lys Glu Glu Thr Lys Lys Ile Ile Ala Ala Leu Arg Ala Ser Leu 
    450                 455                 460                 


Thr Glu Leu Glu Lys Glu Leu Phe Tyr Gln Lys Gln Ala Asn Ile Leu 
465                 470                 475                 480 


Trp Asn Lys Met Gln Met Val Val Thr Glu Gln Ile Tyr Pro Arg Thr 
                485                 490                 495     


Lys Gly Ser Ala Ile Gln Asn Leu Ile Ala Asp Pro Glu Ile Ser Ala 
            500                 505                 510         


Asp Met Leu Lys Gly Val Met Ile Thr Pro Glu Ser Val Asp Tyr Phe 
        515                 520                 525             


Ser Lys Met Ile Tyr Leu Leu Thr Leu Phe Ile Asp Gly Lys Glu Ile 
    530                 535                 540                 


Asn Asp Leu Leu Thr Thr Met Ile Asn Lys Phe Glu Asn Ile Ala Ser 
545                 550                 555                 560 


Phe Val Ser Val Leu Lys Asp Arg Gly Leu Pro Cys Asn Phe Arg Asn 
                565                 570                 575     


Asp Tyr Ser Val Phe Asn Asn Ala Leu Lys Ile Ser Ala Glu Leu Arg 
            580                 585                 590         


Glu Ile Asn Ser Phe Ala Arg Met Glu Lys Ala Thr Pro Gly Ala Lys 
        595                 600                 605             


Lys Gln Met Phe Leu Asp Ala Ala Ile Ile Leu Gly Ser Asn Glu Ser 
    610                 615                 620                 


Ala Glu Glu Leu Ser Glu Tyr Phe Asp Glu Met Leu Asp Lys Gln Lys 
625                 630                 635                 640 


Gly Lys Arg Thr Pro Gly Gly Lys Lys Asp Met Gly Phe Arg Asn Phe 
                645                 650                 655     


Leu Ile Lys Asn Val Ile Glu Ser Asp Arg Phe His Tyr Leu Ile Arg 
            660                 665                 670         


Tyr Gly His Pro Leu His Ile Arg Lys Leu Ala Glu Asn Lys Asn Val 
        675                 680                 685             


Ile Ala Phe Val Leu Lys Gln Ile Pro Glu Pro Gln Ile Asp Arg Tyr 
    690                 695                 700                 


Cys Lys Ile Cys Ala Leu Pro Ala Glu Ser Asn Phe Ala Gln Lys Ile 
705                 710                 715                 720 


Leu Arg Leu Thr Asp Leu Ile Ala Glu Met Asn Phe Arg Gln Phe Glu 
                725                 730                 735     


Asn Val Arg Gln Thr Glu Lys Asn Glu Gln Lys Gln Ile Leu Gln Gly 
            740                 745                 750         


Ile Leu Ser Leu Tyr Leu Thr Val Leu Tyr Leu Leu Thr Lys Asn Leu 
        755                 760                 765             


Val Tyr Val Asn Ser Arg Tyr Phe Leu Ala Phe His Cys Leu Glu Arg 
    770                 775                 780                 


Asp Thr Glu Leu Leu Gly Ser Gln Ala Gly His Lys Asn Ala Glu Lys 
785                 790                 795                 800 


Gln Leu Ile Ala Ser Tyr Ser Ala Leu Thr Gln Gln Phe Leu Asp Glu 
                805                 810                 815     


Gly Lys Leu Asn Arg His Ala Arg Glu Tyr Leu Thr Val Asn Ile Gln 
            820                 825                 830         


Asn Ser Asp Asp Trp Thr Ile Ala Gln Tyr Arg Asn Asn Ala Ala His 
        835                 840                 845             


Leu Asn Ala Ile Arg Asn Ala His Leu Tyr Ile Arg Glu Met Lys Ser 
    850                 855                 860                 


Val Arg Ser Tyr Phe Glu Leu Tyr His Tyr Leu Thr Gln Arg Ala Leu 
865                 870                 875                 880 


Leu Asp Lys Tyr Glu Asn Val Pro Tyr His Pro Gln Val Asn Glu Lys 
                885                 890                 895     


Thr Leu Lys Tyr Phe Glu Leu Leu Lys Glu Asn Gly Trp Tyr Cys Lys 
            900                 905                 910         


Asp Phe Val Lys Ala Leu Asn Val Pro Phe Gly Tyr Asn Leu Pro Arg 
        915                 920                 925             


Tyr Lys Asn Leu Ser Ile Asp Ala Leu Phe Asp Lys Asp Arg Pro Gln 
    930                 935                 940                 


Glu Glu Asp Glu Asn His Leu Tyr Thr Cys Gln Asn Ile Lys Lys Ser 
945                 950                 955                 960 


<210>  3030
<211>  960
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3030

Met Ala Lys Lys Leu Asn Ala Lys Glu Lys Arg Leu Leu Ser Gln Gln 
1               5                   10                  15      


Ala Gln Lys Asp Lys Tyr Lys Lys Met Glu Glu Glu Arg Gln Ala Ala 
            20                  25                  30          


Glu Gln Ala Arg Leu Ala Glu Glu Ala Arg Gln Lys Ala Glu Thr Glu 
        35                  40                  45              


Arg Lys Lys Lys Glu Ala Leu Glu Lys Glu Ala Arg Glu Lys Leu Glu 
    50                  55                  60                  


Lys Glu Leu Leu Glu Lys Asn Pro Ser Leu Lys Lys Val Lys Lys Ser 
65                  70                  75                  80  


Lys Ala Lys Ala Ala Gly Leu Lys Ser Thr Phe Ala Ile Gly Asn Glu 
                85                  90                  95      


Leu Leu Met Thr Ser Phe Gly Lys Gly Asn Glu Ala Val Pro Glu His 
            100                 105                 110         


Tyr Ile Phe Glu Asn Gly Met Ile Ser Met Gln Asn Pro Pro Ala Phe 
        115                 120                 125             


Asp Val Glu Asn Arg Gly Thr Ser Phe Ser Ile Ala Gly Lys Asn Ala 
    130                 135                 140                 


Met Asn Ala Ile Ala Asp Asp Pro Arg Arg Thr Ser Lys Lys Val Ile 
145                 150                 155                 160 


Gly Glu Asp Leu Ile Gly Ala Lys Ser Ala Leu Glu Lys Arg Tyr Phe 
                165                 170                 175     


Gly Lys Thr Phe Glu Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
            180                 185                 190         


Leu Asp Ile Glu Lys Ile Leu Ser Lys His Ile Asn Asn Ile Val Phe 
        195                 200                 205             


Ser Ile Asn Asn Ile Arg Gly Ile Ala Asp Pro Glu Arg Asp Asp Leu 
    210                 215                 220                 


Ile Gly Tyr Met Ser Leu Arg Asp Ser Tyr Glu Tyr Phe Met Asp Glu 
225                 230                 235                 240 


Lys Asn Glu Lys Arg Lys Val Leu Arg Glu Ser Tyr Arg Lys Leu Phe 
                245                 250                 255     


Lys Ser Ser Arg Leu Ser Tyr Phe Gly Ser Ala Phe Tyr Val Glu Lys 
            260                 265                 270         


Gln Ser Thr Gln Lys Lys Lys Ser Gly Gln Lys Asn Phe Glu Leu Arg 
        275                 280                 285             


Asn Glu Lys Asp Cys Tyr Tyr Met Leu Ala Leu Leu Gly Glu Leu Arg 
    290                 295                 300                 


Gln Val Leu Ala His Ser Ser Ala Gln Lys Gln Gly Lys Glu Gln Thr 
305                 310                 315                 320 


Glu Ala Arg Ser Ser Val Tyr Asn Leu Arg Thr Val Gly Asn Asn Asp 
                325                 330                 335     


Met Arg Lys Ile Leu Asn Ser Leu Tyr Ala Glu Arg Val Asp Ala Leu 
            340                 345                 350         


Asn Glu Asn Phe Met Asn Tyr Ala Lys Lys Asp Leu Thr Ile Leu Phe 
        355                 360                 365             


Gly Ile Met Asp Ala Ser Ser Tyr Glu Lys Lys Ala Glu Ile Ala Arg 
    370                 375                 380                 


Asp Phe Tyr Asp Phe Thr Val Arg Lys Ser Tyr Lys Asn Ile Gly Phe 
385                 390                 395                 400 


Ser Ile Lys Lys Ile Arg Glu Arg Met Met Asp Cys Phe Phe Ala Asn 
                405                 410                 415     


Val Lys Glu Ile Thr Pro Asp Ser Pro Asp Phe Gln Ser Val Arg Gln 
            420                 425                 430         


Lys Phe Tyr Lys Ile Leu Asp Phe Leu Leu Phe Thr Tyr Tyr Lys Asp 
        435                 440                 445             


Asn Lys Glu Glu Thr Lys Lys Ile Ile Ala Ala Leu Arg Ala Ser Leu 
    450                 455                 460                 


Thr Glu Leu Glu Lys Glu Leu Phe Tyr Gln Lys Gln Ala Asn Ile Leu 
465                 470                 475                 480 


Trp Asn Lys Met Gln Met Val Val Thr Glu Gln Ile Tyr Pro Arg Thr 
                485                 490                 495     


Lys Gly Ser Ala Ile Gln Asn Leu Ile Ala Asp Pro Glu Ile Ser Ala 
            500                 505                 510         


Asp Met Leu Lys Gly Val Met Ile Thr Pro Glu Ser Val Asp Tyr Phe 
        515                 520                 525             


Ser Lys Met Ile Tyr Leu Leu Thr Leu Phe Ile Asp Gly Lys Glu Ile 
    530                 535                 540                 


Asn Asp Leu Leu Thr Thr Met Ile Asn Lys Phe Glu Asn Ile Ala Ser 
545                 550                 555                 560 


Phe Val Ser Val Leu Lys Asp Arg Gly Leu Pro Cys Asn Phe Arg Asn 
                565                 570                 575     


Asp Tyr Ser Val Phe Asn Asn Ala Leu Lys Ile Ser Ala Glu Leu Arg 
            580                 585                 590         


Glu Ile Asn Ser Phe Ala Arg Met Glu Lys Ala Thr Pro Gly Ala Lys 
        595                 600                 605             


Lys Gln Met Phe Leu Asp Ala Ala Ile Ile Leu Gly Ser Asn Glu Ser 
    610                 615                 620                 


Ala Glu Glu Leu Ser Glu Tyr Phe Asp Glu Met Leu Asp Lys Gln Lys 
625                 630                 635                 640 


Gly Lys Arg Thr Pro Gly Gly Lys Lys Asp Met Gly Phe Arg Asn Phe 
                645                 650                 655     


Leu Ile Lys Asn Val Ile Glu Ser Asp Arg Phe His Tyr Leu Ile Arg 
            660                 665                 670         


Tyr Gly His Pro Leu His Ile Arg Lys Leu Ala Glu Asn Lys Asn Val 
        675                 680                 685             


Ile Ala Phe Val Leu Lys Gln Ile Pro Glu Pro Gln Ile Asp Arg Tyr 
    690                 695                 700                 


Cys Lys Ile Cys Ala Leu Pro Ala Glu Ser Asn Phe Ala Gln Lys Ile 
705                 710                 715                 720 


Leu Arg Leu Thr Asp Leu Ile Ala Glu Met Asn Phe Arg Gln Phe Glu 
                725                 730                 735     


Asn Val Arg Gln Thr Glu Lys Asn Glu Gln Lys Gln Ile Leu Gln Gly 
            740                 745                 750         


Ile Leu Ser Leu Tyr Leu Thr Val Leu Tyr Leu Leu Thr Lys Asn Leu 
        755                 760                 765             


Val Tyr Val Asn Ser Arg Tyr Phe Leu Ala Phe His Cys Leu Glu Arg 
    770                 775                 780                 


Asp Thr Glu Leu Leu Gly Ser Gln Ala Gly His Lys Asn Ala Glu Lys 
785                 790                 795                 800 


Gln Leu Ile Ala Ser Tyr Ser Ala Leu Thr Gln Gln Phe Leu Asp Glu 
                805                 810                 815     


Gly Lys Leu Asn Arg His Ala Arg Glu Tyr Leu Thr Val Asn Ile Gln 
            820                 825                 830         


Asn Ser Asp Asp Trp Thr Ile Ala Gln Tyr Arg Asn Asn Ala Ala His 
        835                 840                 845             


Leu Asn Ala Ile Arg Asn Ala His Leu Tyr Ile Arg Glu Met Lys Ser 
    850                 855                 860                 


Val Arg Ser Tyr Phe Glu Leu Tyr His Tyr Leu Thr Gln Arg Ala Leu 
865                 870                 875                 880 


Leu Asp Lys Tyr Glu Asn Val Pro Tyr His Pro Gln Val Asn Glu Lys 
                885                 890                 895     


Thr Leu Lys Tyr Phe Glu Leu Leu Lys Glu Asn Gly Trp Tyr Cys Lys 
            900                 905                 910         


Asp Phe Val Lys Ala Leu Asn Val Pro Phe Gly Tyr Asn Leu Pro Arg 
        915                 920                 925             


Tyr Lys Asn Leu Ser Ile Asp Ala Leu Phe Asp Lys Asp Arg Pro Gln 
    930                 935                 940                 


Glu Glu Asp Glu Asn His Leu Tyr Thr Cys Gln Asn Ile Lys Lys Ser 
945                 950                 955                 960 


<210>  3031
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3031

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Lys Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asn Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asp Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Phe Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Glu 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Gln Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr 
    850                 855                 860                 


Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  3032
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3032

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Ile Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Pro Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn His Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3033
<211>  1039
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3033

Met Glu Glu Ile Gly Lys Gly Ile Glu Ser Leu Arg Glu Leu Lys Gly 
1               5                   10                  15      


Ala Lys Lys Glu Asn Leu Asp Lys Ser Leu Ala Lys Gln Met Gly Ile 
            20                  25                  30          


Lys Ser Thr Leu Ile Thr Gln Ala Gly Val Ala Ile Ser Ser Phe Ile 
        35                  40                  45              


Glu Thr Thr Thr Ser Ser Gly Lys Lys Ile Pro Asn Ile Glu Ile Leu 
    50                  55                  60                  


Ser Ser Glu Asp Gly Ala Ile Thr His Lys Thr Asn Phe Arg Ala Leu 
65                  70                  75                  80  


Lys Gly Ala Asp Val Ser Ser Lys Thr Ile Lys Val Tyr Ser Ala Ser 
                85                  90                  95      


Gln Lys Thr Gln Phe Ala Asn Pro Ser Gln Gln Leu Gly Ala Asp Tyr 
            100                 105                 110         


Ile Gly Val Lys Gln Ala Leu Glu Asn Lys Phe Phe Gly Lys Thr Phe 
        115                 120                 125             


Ile Lys Asp Asn Val His Val Gln Ile Ala Tyr Asn Val Leu Asp Leu 
    130                 135                 140                 


Lys Lys His Leu Ile Glu Phe Ile Asn Gln Val Ile Tyr Ile Phe Tyr 
145                 150                 155                 160 


Asn Ile Asn Arg Val Thr Asn Asp Tyr Glu Ser Tyr Asp Asp Leu Ile 
                165                 170                 175     


Gly Thr Leu Tyr Thr Phe Ser Asn Tyr Thr Asp Tyr Leu Thr Phe Cys 
            180                 185                 190         


Asn Asn Asn Asn Lys Asp Val Thr Thr Leu Lys Asn Leu Leu Lys Gly 
        195                 200                 205             


Val Ser Phe Tyr Asp Ala Tyr Phe Pro Asn Leu Phe Lys Leu Pro Lys 
    210                 215                 220                 


Glu Lys Asp Gly Lys Ile Ser Gln Glu Glu Ile Glu Lys Cys Asp Ala 
225                 230                 235                 240 


Tyr Asn Phe Asp Ile Leu Arg Leu Leu Ser Leu Met Arg Gln Ser Cys 
                245                 250                 255     


Glu His Glu Asn Met Ser Tyr Gln Asn Asn Lys Val Asn Ala Asp Val 
            260                 265                 270         


Phe Leu Tyr Asp Leu Gln Ala Val Leu Asn Gly Tyr Asn Gln Glu Leu 
        275                 280                 285             


Leu Asp Tyr Leu Asp Asp Leu Tyr Thr Lys Val Pro Ala Gln Phe Asn 
    290                 295                 300                 


Ala Asp Phe Glu Lys Asn Ser Lys Asn Asn Leu Tyr Ile Leu Ser Gln 
305                 310                 315                 320 


Ile Tyr Pro Ser Leu Ser Phe Glu Glu Leu Val Lys Lys Tyr Tyr Asn 
                325                 330                 335     


Phe Ile Ser Val Lys Glu Gln Lys Asn Leu Gly Val Asn Leu Arg Leu 
            340                 345                 350         


Thr Arg Glu Ile Ile Ile Asp Arg Phe Leu Ser Glu Leu Arg Asp Lys 
        355                 360                 365             


Lys Tyr Asp Thr Asn Arg Ser Lys Leu Tyr Thr Val Leu Asp Phe Val 
    370                 375                 380                 


Ile Ser Glu Ile Leu Thr Gly Ser Lys Leu Ile Asp Thr Thr Val Gln 
385                 390                 395                 400 


Lys Leu Arg Val Asn Thr Thr Glu Asp Gly Arg Ile His Val Tyr Leu 
                405                 410                 415     


Asp Phe Ala Thr Gln Leu Trp Gly Gly Asn Lys Asp Leu Ile Lys Phe 
            420                 425                 430         


Ala Leu Ser Cys Tyr Glu Glu Glu Arg Gln Asn Lys Phe Lys Ser Ile 
        435                 440                 445             


Pro Asn Lys Pro Ile Ser Val Arg Asn Gln Ser Tyr Ala Leu Gly Lys 
    450                 455                 460                 


Gln Asn Val Ser Tyr Phe Ser Lys Leu Met Leu Leu Leu Thr Lys Phe 
465                 470                 475                 480 


Leu Asp Gly Lys Glu Ile Asn Val Leu Leu Asn Ser Leu Ile Ser Arg 
                485                 490                 495     


Leu Asp Asn Ile Ala Asp Leu Ile Asp Cys Ala Arg Glu Cys Gly Val 
            500                 505                 510         


Asn Val Glu Phe Lys Lys Glu Tyr Glu Thr Phe Asn Asp Ser Arg Lys 
        515                 520                 525             


Ile Ala Lys Glu Ile Arg Leu Ile Lys Asn Val Ala Lys Met Lys Pro 
    530                 535                 540                 


Glu Ala Thr Ser Ile Lys Asn Cys Met Ile Ile Asp Ala Val Asn Phe 
545                 550                 555                 560 


Leu Gly Val Lys Glu Pro Ile Leu His Trp Cys Glu Cys Thr Thr Glu 
                565                 570                 575     


Glu Gln Lys Ser Lys Asn Lys Glu Phe Leu Asn Arg Ile His Pro Pro 
            580                 585                 590         


Lys Glu Asn Asn Lys Lys Val Asp His Lys Leu Arg Asn Phe Ile Ile 
        595                 600                 605             


Asn Asn Val Val Lys Ser Arg Tyr Phe Ile Tyr Leu Ala Arg Tyr Thr 
    610                 615                 620                 


Lys His Val Asn Cys Arg Ala Val Met Gln Gln Tyr Ser Phe Val Lys 
625                 630                 635                 640 


Phe Val Leu Asn Glu Ile Pro Asp Ala Gln Ile Val Arg Tyr His Lys 
                645                 650                 655     


Ser Val Lys Gly Tyr Gln Glu Asp Asn Ile Ile Lys Ala Arg Asn Val 
            660                 665                 670         


Leu Ser Lys Met Leu Ala Asn Phe Thr Val Asp Glu Leu Phe Asp Lys 
        675                 680                 685             


Val Glu Asn Trp Asp Asp Lys Gln Asn Lys Ser Thr Tyr Glu Asn Ser 
    690                 695                 700                 


Gln Lys Gln Lys Ser Arg Ala Leu Ile Arg Leu Tyr Leu Thr Val Ala 
705                 710                 715                 720 


Tyr Leu Gly Ile Lys Asn Leu Val Asn Val Asn Thr Ile Phe Ser Met 
                725                 730                 735     


Ala Phe Ser Cys Leu Glu Arg Asp Tyr Cys Leu Lys Gln Ile Lys Pro 
            740                 745                 750         


Lys Thr Phe Leu Glu Leu Thr Glu Ser Phe Leu Ser Gln Asp Glu Ile 
        755                 760                 765             


Leu Val Asn Lys Tyr Asn Gln Leu Arg Asp Ser Ile Arg Asp Ser Gln 
    770                 775                 780                 


Leu Ser Lys Gln Glu Lys Lys Val Glu Tyr Lys Lys Gln Leu Val Pro 
785                 790                 795                 800 


Ile Leu Lys Glu Met His Tyr Asp Leu His Ser Tyr Tyr Cys Val Lys 
                805                 810                 815     


Ser Asn Cys Thr Glu Ala Lys Lys Ile Ile Arg Lys Ile Ala Asn Gly 
            820                 825                 830         


Val Val Ser Leu Ser Lys Ser Tyr Arg Asp Cys Val Ala His Leu Asn 
        835                 840                 845             


Val Ile Ile Gln Val Gly Asn Tyr Leu Gly Thr Met Gln Lys Ile Thr 
    850                 855                 860                 


Ser Tyr Tyr Asp Ile Phe Val Tyr Cys Leu Gln Lys Tyr Leu Ile Asp 
865                 870                 875                 880 


Asn Gln Met Gly Phe Val Gly Asp Tyr Asn Asp Asp Leu Ser Ser Val 
                885                 890                 895     


Ile Ile Ser Tyr Asp Lys Ala Ile Lys Gln Ser Gly Phe Tyr Asn Lys 
            900                 905                 910         


Asn Met Leu Trp Leu Leu Asn Val Pro Phe Ala Tyr Asn Leu Ala Arg 
        915                 920                 925             


Tyr Lys Asn Leu Ser Ile Ala Asp Leu Phe Tyr Gly Lys Pro Thr Lys 
    930                 935                 940                 


Gln Thr Ile Lys Asp Val Asn Asn Lys Gln Ile Ser Thr Thr Gln Gln 
945                 950                 955                 960 


Val Glu Ser Ser Asn Ile Asn Val Ala Tyr Asn Val Gly Asp Thr Val 
                965                 970                 975     


Val Met Asp Arg Val Glu Thr Thr Leu Arg Gly Gly Leu Arg Gly Tyr 
            980                 985                 990         


Ile Lys Asn Thr Asn Val Lys Ile  Ala Ile Ser Pro Lys  Thr Leu Lys 
        995                 1000                 1005             


Gly Thr  Asp Ile Asn Lys Tyr  Gln Asn Ala Ser Ile  Leu Val Thr 
    1010                 1015                 1020             


Ile Val  Gly Trp Asp Gln Asn  Ala Gln Val Tyr Asn  Ala Lys Ile 
    1025                 1030                 1035             


Lys 
    


<210>  3034
<211>  918
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3034

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Arg Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Gly Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Asn Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Glu 
    370                 375                 380                 


Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ser Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ser 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Lys Val Ala Lys Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu Arg 
785                 790                 795                 800 


Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr Arg 
                805                 810                 815     


Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu Lys 
            820                 825                 830         


Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile Tyr 
        835                 840                 845             


His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp Asp Lys Lys 
    850                 855                 860                 


Gln Glu Glu Lys Ile Lys Phe Glu Asp Asp Leu Leu Lys Asn His Gly 
865                 870                 875                 880 


Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr Asn 
                885                 890                 895     


Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg Asn 
            900                 905                 910         


Glu Tyr Leu Thr Glu Lys 
        915             


<210>  3035
<211>  975
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3035

Met Met Gly Lys His Leu Asn Ala Lys Gln Arg Glu Leu Glu Lys Lys 
1               5                   10                  15      


Leu Lys Asn Gln Gln Lys Gly Met Met Tyr Asn Lys Ser Thr Asp Ala 
            20                  25                  30          


Val Ser Val Pro Thr Leu Gln Ala Ala Pro Lys Lys Ala Ala Glu Ala 
        35                  40                  45              


Ser Thr Leu Ile Thr Pro Gly Thr Leu Lys Thr Lys Ala Lys Ala Met 
    50                  55                  60                  


Gly Leu Lys Ser Thr Leu Val Phe Asp Asp Lys Ile Val Val Thr Ser 
65                  70                  75                  80  


Phe Leu Asn Ser Lys Thr Glu Glu Asn Glu Lys Cys Ala His Ile Glu 
                85                  90                  95      


Lys Ile Thr Asp Cys Asn Gly Gln Thr Ile Val Glu Arg Pro Arg Met 
            100                 105                 110         


Phe Asn Thr Ser Ile Asn Ala Gln Gln Val Asp Leu Ser Lys Asp Asn 
        115                 120                 125             


Asp Glu Thr Asn Tyr Pro Asn Pro Ala Phe Glu Asp Cys Gly Arg Asp 
    130                 135                 140                 


Tyr Ile Asn Ile Lys Ser Ala Leu Glu Lys Arg Val Phe Gly Lys Thr 
145                 150                 155                 160 


Tyr Asn Lys Asp Asn Leu His Val Gln Ile Ala Tyr Asn Ile Phe Asp 
                165                 170                 175     


Ile Lys Lys Ile Ile Gly Thr Tyr Ile Asn Asn Ile Thr Tyr Ile Phe 
            180                 185                 190         


Tyr Asn Leu Gly Arg Glu Glu Tyr Asn Ala Lys Lys Asp Ile Ile Gly 
        195                 200                 205             


Asn Gln Asp Ser Asp Tyr Ile Asn Lys Leu Leu Asn Asn Thr Ser Ala 
    210                 215                 220                 


Tyr Phe Thr Tyr Phe Asp Gly Val Phe Lys Gln Ile Thr Asp Arg Asp 
225                 230                 235                 240 


Ser Asn Lys Asp Arg Glu Val Lys Asn Ser Tyr Asn Ala Leu Val Leu 
                245                 250                 255     


Lys Val Leu Tyr Tyr Leu Arg Gln Phe Cys Met His Gly Asn Thr Tyr 
            260                 265                 270         


Thr Lys Arg Asn Glu Glu Ser Phe Leu Ser Asp Thr Ala Leu Tyr Asn 
        275                 280                 285             


Val Lys Asp Phe Phe Ala Lys Ala Asp Pro Gln Ile Asn Glu Leu Ile 
    290                 295                 300                 


Asp Ala Val Tyr Ala Asp Gly Ile Lys Thr Ile Asn Asn Asp Phe Met 
305                 310                 315                 320 


Ala His Ala Lys Asn Asn Met Tyr Ile Ile Cys Glu Val Tyr Lys Asn 
                325                 330                 335     


Glu Val Glu Asp Ser Leu Met Lys Glu Tyr Tyr Asp Phe Val Val Arg 
            340                 345                 350         


Lys Glu Gly Asn Asn Leu Gly Phe Asn Thr Arg Gln Leu Arg Glu Ile 
        355                 360                 365             


Leu Ile Asp Lys Tyr Val Gly Asn Leu Arg Asp Lys Lys Tyr Asp Thr 
    370                 375                 380                 


Phe Arg Asn Lys Leu Tyr Thr Val Leu Gly Phe Ile Leu Val Lys Glu 
385                 390                 395                 400 


Ile Lys Arg Asn Pro Lys Ile Gln Asp Ser Phe Ile Ala Lys Leu Arg 
                405                 410                 415     


Ala Asn Gln Ser Gly Asp Glu Gly Lys Leu Asn Ile Tyr Asn Glu Phe 
            420                 425                 430         


Ala Pro Lys Ile Trp Ser Val Val Ser Ser Lys Phe Asn Ser Ala Ile 
        435                 440                 445             


Lys Cys Phe Asp Glu Glu Ser Leu Ser Lys Phe Lys Gly Tyr Lys Asp 
    450                 455                 460                 


Ile Asp Glu Ser Leu Ile Ser Lys Tyr Gly Ile Thr Val Ser Asn Thr 
465                 470                 475                 480 


Asp Thr Leu Val Lys Ile Leu Tyr Phe Leu Cys Lys Phe Leu Asp Gly 
                485                 490                 495     


Lys Glu Ile Asn Glu Leu Cys Cys Ala Met Ile Asn Lys Phe Asp Asn 
            500                 505                 510         


Ile Asn Asp Leu Ile Lys Thr Ala Ala Gln Cys Gly Glu Asp Ile Glu 
        515                 520                 525             


Phe Val Lys Glu Tyr Lys Leu Phe Ile Asn Ser Lys Asp Leu Ser Asp 
    530                 535                 540                 


Gln Ile Arg Val Val Lys Ser Ile Ser Lys Met Lys Pro Glu Leu Ser 
545                 550                 555                 560 


Asn Ile Gly Glu Val Leu Leu Leu Asp Ala Ile Asp Ile Leu Gly Tyr 
                565                 570                 575     


Lys Ile Asn Lys Tyr Lys Cys Asp Ala Asp Gly Asn Arg Leu Val Asp 
            580                 585                 590         


Ser Asn Asn Lys Pro Val Tyr Ser Glu Glu Tyr Cys Thr Phe Lys Lys 
        595                 600                 605             


Asp Phe Phe Glu Thr Cys Glu Leu Asp Glu Phe Gly Arg Val Lys Tyr 
    610                 615                 620                 


Asp Lys Lys Gly Lys Pro Val Ile Asn His Arg Arg Arg Asn Phe Ile 
625                 630                 635                 640 


Ile Asn Asn Val Leu Ser Ser Lys Trp Phe Phe Tyr Val Ala Lys Tyr 
                645                 650                 655     


Asn Arg Pro Ser Glu Cys Gln Lys Phe Met Lys Ser Lys Lys Leu Ile 
            660                 665                 670         


Ala Leu Ala Leu Lys Asp Val Pro Glu Thr Gln Ile Ala Arg Tyr Tyr 
        675                 680                 685             


His Ser Val Thr Gly Gly Arg Glu Gln Thr Asp Ser Glu Ala Met Arg 
    690                 695                 700                 


Thr Thr Leu Ile Ser Arg Leu His Glu Phe Ser Ile Lys Asp Val Leu 
705                 710                 715                 720 


Ser Ser Val Gly Ser Met Thr Ala Ser Glu Asn Lys Arg Gln Ile Glu 
                725                 730                 735     


Asn Ser Arg Lys Glu Gln Met Lys Ala Ile Val Lys Leu Tyr Leu Thr 
            740                 745                 750         


Val Val Tyr Leu Ile Ala Lys Ser Leu Val Lys Val Asn Thr Arg Phe 
        755                 760                 765             


Ser Ile Ala Phe Ser Ala Tyr Glu Arg Asp Val Ser Leu Leu Ala Asp 
    770                 775                 780                 


Glu Asn Glu Ser Ile Ala Leu Ala Asp Asn Asp Asp Asp Lys Trp Lys 
785                 790                 795                 800 


Thr Gly Asn Tyr Ile Phe Ala Leu Thr Lys His Phe Leu Asp Asn Asp 
                805                 810                 815     


Glu Pro Tyr Phe Asp Lys Tyr Asn Asn Ala Leu Gln Gln Ile Lys Gly 
            820                 825                 830         


Ile Thr Asp Pro Asn Glu Arg Arg Leu Ala Tyr Arg Ala Asn Asp Lys 
        835                 840                 845             


Val Ile Lys His Thr His Phe Asn Leu His Thr Asn Lys Tyr Val Lys 
    850                 855                 860                 


Asp Asn Tyr Glu Lys Ile Ser Lys Met Asn Lys Ile Val Thr Glu Tyr 
865                 870                 875                 880 


Arg Asn Asn Val Gln His Leu Ala Val Val Asn Asn Ile Thr Lys Tyr 
                885                 890                 895     


Leu Gly Asp Ile Ser Glu Val Thr Ser Tyr Tyr Ser Leu Tyr Cys Tyr 
            900                 905                 910         


Ile Leu Gln Arg Leu Leu Leu Asp Asn Asn Asn Asn Asp Lys Phe Ala 
        915                 920                 925             


Glu Ile Lys Glu Lys Leu Ile Lys Phe Gly Thr Tyr Asn Lys Asp Phe 
    930                 935                 940                 


Met Trp Leu Ile Asn Val Pro Phe Ala Tyr Asn Leu Pro Arg Tyr Lys 
945                 950                 955                 960 


Asn Leu Ser Asn Glu Glu Ile Phe Tyr Asp Val Ile Gln Asn Lys 
                965                 970                 975 


<210>  3036
<211>  954
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3036

Met Gly Lys Lys Ile His Ala Arg Asp Leu Arg Glu Gln Arg Lys Thr 
1               5                   10                  15      


Asp Arg Thr Glu Lys Phe Ala Asp Gln Asn Lys Lys Arg Glu Ala Glu 
            20                  25                  30          


Arg Ala Val Gln Lys Lys Asp Ala Ala Val Ser Val Lys Ser Val Ser 
        35                  40                  45              


Ser Val Ser Ser Lys Lys Asp Asn Val Thr Lys Ser Met Ala Lys Ala 
    50                  55                  60                  


Ala Gly Val Lys Ser Val Phe Ala Val Gly Asn Thr Val Tyr Met Thr 
65                  70                  75                  80  


Ser Phe Gly Arg Gly Asn Asp Ala Val Leu Glu Gln Lys Ile Val Asp 
                85                  90                  95      


Thr Ser His Glu Pro Leu Asn Ile Asp Asp Pro Ala Tyr Gln Leu Asn 
            100                 105                 110         


Val Val Thr Met Asn Gly Tyr Ser Val Thr Gly His Arg Gly Glu Thr 
        115                 120                 125             


Val Ser Ala Val Thr Asp Asn Pro Leu Arg Arg Phe Asn Gly Gly Lys 
    130                 135                 140                 


Lys Asp Glu Pro Glu Gln Ser Val Pro Thr Asp Met Leu Cys Leu Lys 
145                 150                 155                 160 


Pro Thr Leu Glu Lys Lys Phe Phe Gly Lys Glu Phe Asn Asp Asn Ile 
                165                 170                 175     


His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala 
            180                 185                 190         


Val Tyr Ser Thr Asn Ala Ile Tyr Ala Leu Asn Asn Met Ser Ala Asp 
        195                 200                 205             


Glu Asn Ile Glu Asn Ser Asp Phe Phe Met Lys Arg Thr Thr Asp Glu 
    210                 215                 220                 


Thr Phe Asp Asp Phe Glu Lys Lys Lys Glu Ser Thr Asn Ser Arg Glu 
225                 230                 235                 240 


Lys Ala Asp Phe Asp Ala Phe Glu Lys Phe Ile Gly Asn Tyr Arg Leu 
                245                 250                 255     


Ala Tyr Phe Ala Asp Ala Phe Tyr Val Asn Lys Lys Asn Pro Lys Gly 
            260                 265                 270         


Lys Ala Lys Asn Val Leu Arg Glu Asp Lys Glu Leu Tyr Ser Val Leu 
        275                 280                 285             


Thr Leu Ile Gly Lys Leu Arg His Trp Cys Val His Ser Glu Asp Gly 
    290                 295                 300                 


Arg Ala Glu Phe Trp Leu Tyr Lys Leu Asp Glu Leu Lys Asp Asp Phe 
305                 310                 315                 320 


Lys Asn Val Leu Asp Val Val Tyr Asn Arg Pro Val Glu Glu Ile Asn 
                325                 330                 335     


Asn Arg Phe Ile Glu Asn Asn Lys Val Asn Ile Gln Ile Leu Gly Ser 
            340                 345                 350         


Val Tyr Lys Asn Thr Asp Ile Ala Glu Leu Val Arg Ser Tyr Tyr Glu 
        355                 360                 365             


Phe Leu Ile Thr Lys Lys Tyr Lys Asn Met Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Ser Met Leu Glu Gly Lys Gly Tyr Ala Asp Lys Glu Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Asn Lys Leu Tyr Gln Met Thr Asp Phe Ile Leu Tyr 
                405                 410                 415     


Thr Gly Tyr Ile Asn Glu Asp Ser Asp Arg Ala Asp Asp Leu Val Asn 
            420                 425                 430         


Thr Leu Arg Ser Ser Leu Lys Glu Asp Asp Lys Thr Thr Val Tyr Cys 
        435                 440                 445             


Lys Glu Ala Asp Tyr Leu Trp Lys Lys Tyr Arg Glu Ser Ile Arg Glu 
    450                 455                 460                 


Val Ala Asp Ala Leu Asp Val Asp Asn Ile Lys Asn Leu Ser Gly Ser 
465                 470                 475                 480 


Asn Ile Glu Ile Arg Asp Asn Glu Leu Arg Lys Cys Phe Ile Ser Tyr 
                485                 490                 495     


Ala Asp Ser Val Ser Glu Phe Thr Lys Leu Ile Tyr Leu Leu Thr Arg 
            500                 505                 510         


Phe Leu Ser Gly Lys Glu Ile Asn Asp Leu Val Thr Thr Leu Ile Asn 
        515                 520                 525             


Lys Phe Asp Asn Ile Arg Ser Phe Leu Glu Ile Met Asp Glu Leu Gly 
    530                 535                 540                 


Leu Asp Arg Thr Phe Thr Ala Glu Tyr Ser Phe Phe Glu Gly Ser Thr 
545                 550                 555                 560 


Lys Tyr Leu Ala Glu Leu Val Glu Leu Asn Ser Phe Val Lys Ser Cys 
                565                 570                 575     


Ser Phe Asp Ile Asn Ala Lys Arg Thr Met Tyr Arg Asp Ala Leu Asp 
            580                 585                 590         


Ile Leu Gly Ile Lys Ser Gly Lys Thr Glu Glu Asp Ile Glu Lys Met 
        595                 600                 605             


Ile Asp Asn Ile Leu Gln Ile Asp Ala Asn Gly Asp Lys Lys Leu Lys 
    610                 615                 620                 


Lys Asn Asn Gly Leu Arg Asn Phe Ile Ala Ser Asn Val Ile Asp Ser 
625                 630                 635                 640 


Asn Arg Phe Lys Tyr Leu Val Arg Tyr Gly Asn Pro Lys Lys Ile Arg 
                645                 650                 655     


Glu Thr Ala Lys Cys Lys Pro Ala Val Arg Phe Val Leu Asn Glu Ile 
            660                 665                 670         


Pro Asp Ala Gln Ile Glu Arg Tyr Tyr Glu Ala Cys Cys Pro Lys Asn 
        675                 680                 685             


Thr Ala Leu Cys Ser Ala Asn Lys Arg Arg Glu Lys Leu Ala Asp Met 
    690                 695                 700                 


Ile Ala Glu Ile Lys Phe Glu Asn Phe Ser Asp Ala Gly Asn Tyr Gln 
705                 710                 715                 720 


Lys Ala Asn Val Thr Ser Arg Thr Ser Glu Ala Glu Ile Lys Arg Lys 
                725                 730                 735     


Asn Gln Ala Ile Ile Arg Leu Tyr Leu Thr Val Met Tyr Ile Met Leu 
            740                 745                 750         


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Phe His Cys 
        755                 760                 765             


Val Glu Arg Asp Thr Lys Leu Tyr Ala Glu Ser Gly Leu Glu Val Gly 
    770                 775                 780                 


Asn Ile Glu Lys Asn Lys Thr Asn Leu Thr Met Ala Val Met Gly Val 
785                 790                 795                 800 


Lys Leu Glu Asn Gly Thr Ile Lys Thr Glu Phe Asp Lys Ser Leu Ala 
                805                 810                 815     


Glu Asn Ala Ala Asn Arg Tyr Leu Arg Asn Ala Arg Trp Tyr Lys Leu 
            820                 825                 830         


Ile Leu Asp Asn Leu Lys Lys Ser Glu Arg Ala Val Val Thr Glu Phe 
        835                 840                 845             


Arg Asn Thr Val Cys His Leu Asn Ala Ile Arg Asn Ile Asn Ile Asn 
    850                 855                 860                 


Ile Lys Glu Ile Lys Glu Val Glu Asn Tyr Phe Ala Leu Tyr His Tyr 
865                 870                 875                 880 


Leu Ile Gln Lys His Leu Glu Asn Arg Phe Ala Asp Lys Lys Val Glu 
                885                 890                 895     


Arg Asp Thr Gly Asp Phe Ile Ser Lys Leu Glu Glu His Lys Thr Tyr 
            900                 905                 910         


Cys Lys Asp Phe Val Lys Ala Tyr Cys Thr Pro Phe Gly Tyr Asn Leu 
        915                 920                 925             


Val Arg Tyr Lys Asn Leu Thr Ile Asp Gly Leu Phe Asp Lys Asn Tyr 
    930                 935                 940                 


Pro Gly Lys Asp Asp Ser Asp Lys Gln Lys 
945                 950                 


<210>  3037
<211>  960
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3037

Met Ala Lys Lys Leu Asn Ala Lys Glu Lys Arg Leu Leu Ser Gln Gln 
1               5                   10                  15      


Ala Gln Lys Asp Lys Tyr Lys Lys Met Glu Glu Glu Arg Gln Ala Ala 
            20                  25                  30          


Glu Gln Ala Arg Leu Ala Glu Glu Ala Arg Gln Lys Ala Glu Thr Glu 
        35                  40                  45              


Arg Lys Lys Lys Glu Ala Leu Glu Lys Glu Ala Arg Glu Lys Leu Glu 
    50                  55                  60                  


Lys Glu Leu Leu Glu Lys Asn Pro Ser Leu Lys Lys Val Lys Lys Ser 
65                  70                  75                  80  


Lys Ala Lys Ala Ala Gly Leu Lys Ser Thr Phe Ala Ile Gly Asn Glu 
                85                  90                  95      


Leu Leu Met Thr Ser Phe Gly Lys Gly Asn Glu Ala Val Pro Glu His 
            100                 105                 110         


Tyr Ile Phe Glu Asn Gly Met Ile Ser Met Gln Asn Pro Pro Ala Phe 
        115                 120                 125             


Asp Val Glu Asn Arg Gly Thr Ser Phe Ser Ile Ala Gly Lys Asn Ala 
    130                 135                 140                 


Met Asn Ala Ile Ala Asp Asp Pro Arg Arg Thr Ser Lys Lys Val Ile 
145                 150                 155                 160 


Gly Glu Asp Leu Ile Gly Ala Lys Ser Ala Leu Glu Lys Arg Tyr Phe 
                165                 170                 175     


Gly Lys Thr Phe Glu Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
            180                 185                 190         


Leu Asp Ile Glu Lys Ile Leu Ser Lys His Ile Asn Asn Ile Val Phe 
        195                 200                 205             


Ser Ile Asn Asn Ile Arg Gly Ile Ala Asp Pro Glu Arg Asp Asp Leu 
    210                 215                 220                 


Ile Gly Tyr Met Ser Leu Arg Asp Ser Tyr Glu Tyr Phe Met Asp Glu 
225                 230                 235                 240 


Lys Asn Glu Lys Arg Lys Val Leu Arg Glu Ser Tyr Arg Lys Leu Phe 
                245                 250                 255     


Lys Ser Ser Arg Leu Ser Tyr Phe Gly Ser Ala Phe Tyr Val Glu Lys 
            260                 265                 270         


Gln Ser Thr Gln Lys Lys Lys Ser Gly Gln Lys Asn Phe Glu Leu Arg 
        275                 280                 285             


Asn Glu Lys Asp Cys Tyr Tyr Met Leu Ala Leu Leu Gly Glu Leu Arg 
    290                 295                 300                 


Gln Val Leu Ala His Ser Ser Ala Gln Lys Gln Gly Lys Glu Gln Thr 
305                 310                 315                 320 


Glu Ala Arg Ser Ser Val Tyr Asn Leu Arg Thr Val Gly Asn Asn Asp 
                325                 330                 335     


Met Arg Lys Ile Leu Asn Ser Leu Tyr Ala Glu Arg Val Asp Ala Leu 
            340                 345                 350         


Asn Glu Asn Phe Met Asn Tyr Ala Lys Lys Asp Leu Thr Ile Leu Phe 
        355                 360                 365             


Gly Ile Met Asp Ala Ser Ser Tyr Glu Lys Lys Ala Glu Ile Ala Arg 
    370                 375                 380                 


Asp Phe Tyr Asp Phe Thr Val Arg Lys Ser Tyr Lys Asn Ile Gly Phe 
385                 390                 395                 400 


Ser Ile Lys Lys Ile Arg Glu Arg Met Met Asp Cys Phe Phe Ala Asn 
                405                 410                 415     


Val Lys Glu Ile Thr Pro Asp Ser Pro Asp Phe Gln Ser Val Arg Gln 
            420                 425                 430         


Lys Phe Tyr Lys Ile Leu Asp Phe Leu Leu Phe Thr Tyr Tyr Lys Asp 
        435                 440                 445             


Asn Lys Glu Glu Thr Lys Lys Ile Ile Ala Ala Leu Arg Ala Ser Leu 
    450                 455                 460                 


Thr Glu Leu Glu Lys Glu Leu Phe Tyr Gln Lys Gln Ala Asn Ile Leu 
465                 470                 475                 480 


Trp Asn Lys Met Gln Met Val Val Thr Glu Gln Ile Tyr Pro Arg Thr 
                485                 490                 495     


Lys Gly Ser Ala Ile Gln Asn Leu Ile Ala Asp Pro Glu Ile Ser Ala 
            500                 505                 510         


Asp Met Leu Lys Gly Val Met Ile Thr Pro Glu Ser Val Asp Tyr Phe 
        515                 520                 525             


Ser Lys Met Ile Tyr Leu Leu Thr Leu Phe Ile Asp Gly Lys Glu Ile 
    530                 535                 540                 


Asn Asp Leu Leu Thr Thr Met Ile Asn Lys Phe Glu Asn Ile Ala Ser 
545                 550                 555                 560 


Phe Val Ser Val Leu Lys Asp Arg Gly Leu Pro Cys Asn Phe Arg Asn 
                565                 570                 575     


Asp Tyr Ser Val Phe Asn Asn Ala Leu Lys Ile Ser Ala Glu Leu Arg 
            580                 585                 590         


Glu Ile Asn Ser Phe Ala Arg Met Glu Lys Ala Thr Pro Gly Ala Lys 
        595                 600                 605             


Lys Gln Met Phe Leu Asp Ala Ala Ile Ile Leu Gly Ser Asn Glu Ser 
    610                 615                 620                 


Ala Glu Glu Leu Ser Glu Tyr Phe Asp Glu Met Leu Asp Lys Gln Lys 
625                 630                 635                 640 


Gly Lys Arg Thr Pro Gly Gly Lys Lys Asp Met Gly Phe Arg Asn Phe 
                645                 650                 655     


Leu Ile Lys Asn Val Ile Glu Ser Asp Arg Phe His Tyr Leu Ile Arg 
            660                 665                 670         


Tyr Gly His Pro Leu His Ile Arg Lys Leu Ala Glu Asn Lys Asn Val 
        675                 680                 685             


Ile Ala Phe Val Leu Lys Gln Ile Pro Glu Pro Gln Ile Asp Arg Tyr 
    690                 695                 700                 


Cys Lys Ile Cys Ala Leu Pro Ala Glu Ser Asn Phe Ala Gln Lys Ile 
705                 710                 715                 720 


Leu Arg Leu Thr Asp Leu Ile Ala Glu Met Asn Phe Arg Gln Phe Glu 
                725                 730                 735     


Asn Val Arg Gln Thr Glu Lys Asn Glu Gln Lys Gln Ile Leu Gln Gly 
            740                 745                 750         


Ile Leu Ser Leu Tyr Leu Thr Val Leu Tyr Leu Leu Thr Lys Asn Leu 
        755                 760                 765             


Val Tyr Val Asn Ser Arg Tyr Phe Leu Ala Phe His Cys Leu Glu Arg 
    770                 775                 780                 


Asp Thr Glu Leu Leu Gly Ser Gln Ala Gly His Lys Asn Ala Glu Lys 
785                 790                 795                 800 


Gln Leu Ile Ala Ser Tyr Ser Ala Leu Thr Gln Gln Phe Leu Asp Glu 
                805                 810                 815     


Gly Lys Leu Asn Arg His Ala Arg Glu Tyr Leu Thr Val Asn Ile Gln 
            820                 825                 830         


Asn Ser Asp Asp Trp Thr Ile Ala Gln Tyr Arg Asn Asn Ala Ala His 
        835                 840                 845             


Leu Asn Ala Ile Arg Asn Ala His Leu Tyr Ile Arg Glu Met Lys Ser 
    850                 855                 860                 


Val Arg Ser Tyr Phe Glu Leu Tyr His Tyr Leu Thr Gln Arg Ala Leu 
865                 870                 875                 880 


Leu Asp Lys Tyr Glu Asn Val Pro Tyr His Pro Gln Val Asn Glu Lys 
                885                 890                 895     


Thr Leu Lys Tyr Phe Glu Leu Leu Lys Glu Asn Gly Trp Tyr Cys Lys 
            900                 905                 910         


Asp Phe Val Lys Ala Leu Asn Val Pro Phe Gly Tyr Asn Leu Pro Arg 
        915                 920                 925             


Tyr Lys Asn Leu Ser Ile Asp Ala Leu Phe Asp Lys Asp Arg Pro Gln 
    930                 935                 940                 


Glu Glu Asp Glu Asn His Leu Tyr Thr Cys Gln Asn Ile Lys Lys Ser 
945                 950                 955                 960 


<210>  3038
<211>  921
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3038

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Gly Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Asn Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp 
    370                 375                 380                 


Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Val Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Asn Pro Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn Arg 
785                 790                 795                 800 


Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser 
                805                 810                 815     


Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg 
            820                 825                 830         


Glu Leu Lys Glu Tyr Ile Gly Asp Ile Cys Thr Val Asp Ser Tyr Phe 
        835                 840                 845             


Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn 
    850                 855                 860                 


Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys 
865                 870                 875                 880 


Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe 
                885                 890                 895     


Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe 
            900                 905                 910         


Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920     


<210>  3039
<211>  918
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3039

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Gly Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Asn Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp 
    370                 375                 380                 


Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Gly Val Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ser Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu Arg 
785                 790                 795                 800 


Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr Arg 
                805                 810                 815     


Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu Lys 
            820                 825                 830         


Glu Tyr Ile Gly Asp Ile Cys Thr Val Asp Ser Tyr Phe Ser Ile Tyr 
        835                 840                 845             


His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr Lys 
    850                 855                 860                 


Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His Gly 
865                 870                 875                 880 


Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr Asn 
                885                 890                 895     


Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg Asn 
            900                 905                 910         


Glu Tyr Leu Thr Glu Lys 
        915             


<210>  3040
<211>  918
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3040

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Gly Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Asn Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp 
    370                 375                 380                 


Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Gly Val Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ser Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu Arg 
785                 790                 795                 800 


Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr Arg 
                805                 810                 815     


Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu Lys 
            820                 825                 830         


Glu Tyr Ile Gly Asp Ile Cys Thr Val Asp Ser Tyr Phe Ser Ile Tyr 
        835                 840                 845             


His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr Lys 
    850                 855                 860                 


Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His Gly 
865                 870                 875                 880 


Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr Asn 
                885                 890                 895     


Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg Asn 
            900                 905                 910         


Glu Tyr Leu Thr Glu Lys 
        915             


<210>  3041
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3041

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Gln Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser 
        195                 200                 205             


His Asp Asp Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val 
    210                 215                 220                 


Phe Ile Asp Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn 
225                 230                 235                 240 


Val Arg Lys Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Asn Arg Val 
            260                 265                 270         


Ser Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Glu Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Ile Ala Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Leu Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Lys Val Ala Glu Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Lys Lys Gln Glu Glu Lys Ile Lys Phe Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3042
<211>  1023
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3042

Met Ala Lys Lys Ile Thr Ala Lys Gln Lys Arg Glu Glu Lys Glu Arg 
1               5                   10                  15      


Leu Asn Lys Gln Lys Trp Ala Lys Gln Asp Thr Pro Val Val Pro Lys 
            20                  25                  30          


Ser Lys Thr Glu Glu Lys Pro Val Ala Ala Ser Asp Asp Lys Leu Leu 
        35                  40                  45              


Lys Thr Thr Gln Val Lys Lys Val Gln Thr Lys Ser Lys Ala Lys Ala 
    50                  55                  60                  


Met Gly Leu Lys Thr Val Leu Ser Phe Asp Asp Lys Ile Ala Ile Ala 
65                  70                  75                  80  


Ser Phe Val Asn Asp Lys Lys Thr Lys Leu Pro His Ile Glu Arg Ile 
                85                  90                  95      


Thr Asp Lys Ser Gly Thr Thr Ile His Glu Asn Ala Arg Met Phe Asp 
            100                 105                 110         


Ser Ser Val Asp Glu Gln Asn Val Asn Ile Glu Lys Arg Met Thr Ile 
        115                 120                 125             


Glu Glu Lys Gln Asn Asp Gly Thr Phe Lys Lys Asp Glu Lys Asp Val 
    130                 135                 140                 


Lys Ala Thr Ile Cys Asn Pro Tyr Phe Lys Thr Cys Gly Lys Asp Tyr 
145                 150                 155                 160 


Ile Gly Ile Lys Asp Val Ala Glu Lys Tyr Phe Phe Gly Lys Thr Phe 
                165                 170                 175     


Pro Asn Glu Asn Leu Arg Val Gln Ile Ala Tyr Asn Val Phe Asp Ile 
            180                 185                 190         


Gln Lys Ile Leu Gly Thr Tyr Val Asn Asn Ile Ile Tyr Ser Phe Tyr 
        195                 200                 205             


Asn Leu Arg Arg Asp Gly Lys Ser Asp Val Asp Ile Ile Gly Ser Leu 
    210                 215                 220                 


Tyr Ala Phe Ala Asp Phe Asp Asn Gln Leu Lys Asp Lys Pro Ala Phe 
225                 230                 235                 240 


Arg Glu Ala Lys Asp Leu Leu Lys Asn Thr Glu Ala Tyr Phe Ser Tyr 
                245                 250                 255     


Phe Gly Asp Val Phe Lys Lys Ser Lys Lys Gly Lys Lys Asp Glu Asn 
            260                 265                 270         


Asn Glu Asp Tyr Glu Lys Asn Leu Arg His Asn Phe Asn Val Leu Arg 
        275                 280                 285             


Val Leu Ser Phe Leu Arg Gln Ile Cys Thr His Ala Tyr Val Lys Cys 
    290                 295                 300                 


Thr Ser Gly Ala Lys Asn Asn Gly Asp Ser Thr Lys Val Val Ala Glu 
305                 310                 315                 320 


Ser Leu Asp Ala Leu Phe Asn Ile Thr Glu Tyr Phe Asp Lys Thr Ala 
                325                 330                 335     


Pro Glu Leu Ser Lys Thr Ile Asn Glu Ile Tyr Lys Glu Gly Val Asp 
            340                 345                 350         


Arg Ile Asn Asn Asp Phe Val Thr Asn Gly Lys Asn Asn Leu Tyr Ile 
        355                 360                 365             


Leu Ser Lys Val Tyr Pro Asp Met Gln Arg Asn Glu Leu Val Lys Lys 
    370                 375                 380                 


Tyr Tyr Gln Phe Val Val Cys Lys Glu Gly Asn Asn Val Gly Ile Asn 
385                 390                 395                 400 


Thr Arg Lys Leu Lys Glu Ser Ile Ile Ser Gln Asn Pro Trp Ile Thr 
                405                 410                 415     


Thr Pro Gln Asp Asn Asn Lys Ala Asn Asp Tyr Lys Ser Cys Gln His 
            420                 425                 430         


Lys Leu Tyr Thr Ile Met Cys Phe Ile Leu Val Ala Glu Leu Asp Ala 
        435                 440                 445             


His Glu Ser Ile Arg Asp Asn Met Val Ala Glu Leu Arg Ala Asn Met 
    450                 455                 460                 


Asp Gly Asp Asp Gly Arg Asp Ala Ile Tyr Glu Lys Tyr Ala Lys Asp 
465                 470                 475                 480 


Ile Tyr His Ile Val Lys Asp Lys Leu Leu Ala Met Gln Lys Val Phe 
                485                 490                 495     


Asp Glu Glu Leu Val Pro Val Lys Val Glu Glu Glu Asn Asp Pro Gln 
            500                 505                 510         


Arg Phe Thr His Gly Lys Leu Gly Lys Lys Glu Ile Glu Ser Phe Cys 
        515                 520                 525             


Leu Ser Asp Lys Asn Thr Ser Asp Ile Ala Lys Val Val Tyr Phe Leu 
    530                 535                 540                 


Cys Asn Phe Leu Asp Gly Lys Glu Ile Asn Glu Leu Cys Cys Ala Met 
545                 550                 555                 560 


Met Asn Lys Phe Asp Gly Ile Gly Asp Leu Ile Asp Thr Ala Lys Gln 
                565                 570                 575     


Cys Gly Glu Glu Val Lys Phe Ile Glu Lys Phe Ala Cys Leu Ser Asn 
            580                 585                 590         


Cys Arg Lys Ile Thr Asp Asp Ile Arg Val Ala Lys Ser Ile Ser Lys 
        595                 600                 605             


Met Lys Asn Lys Val Lys Ile Asp Asn Asp Ile Ile Tyr Leu Asp Ala 
    610                 615                 620                 


Ile Glu Leu Leu Gly Arg Lys Ile Glu Lys Tyr Gln Lys Asp Glu Ser 
625                 630                 635                 640 


Gly Lys Ile Leu Leu Gly Thr Asp Gly Lys Arg Leu Tyr Thr Lys Glu 
                645                 650                 655     


Tyr Lys Tyr Phe Asn Asp Met Phe Phe Asn Ala Gly Asn His Lys Val 
            660                 665                 670         


Arg Lys Phe Ile Asn Asn Asn Val Met Lys Ser Lys Trp Phe Phe Tyr 
        675                 680                 685             


Val Val Arg Tyr Asn Lys Pro Ala Glu Cys Gln Ile Ile Met Arg Asn 
    690                 695                 700                 


Lys Thr Leu Val Lys Phe Thr Leu Asp Asp Leu Pro Asp Glu Gln Ile 
705                 710                 715                 720 


Gln Arg Tyr Tyr Ser Ser Val Phe Gly Asp Asn Asn Met Pro Thr Val 
                725                 730                 735     


Asp Val Met Arg Glu Trp Leu Leu Lys Lys Ile Asn Gln Phe Ser Val 
            740                 745                 750         


Arg Gly Phe Leu Asp Asp Ile Asp Glu Glu Ser Lys Gln Asn Lys Ser 
        755                 760                 765             


Ser Glu Thr Glu Gln Lys Lys Ser Leu Ile Arg Leu Tyr Leu Thr Ile 
    770                 775                 780                 


Ala Tyr Leu Ile Thr Lys Ser Met Val Lys Ile Asn Thr Arg Phe Ser 
785                 790                 795                 800 


Ile Ala Cys Ala Thr Tyr Glu Arg Asp Tyr Ala Leu Leu Cys Gln Ser 
                805                 810                 815     


Gln Gln Lys Gly Gly Pro Trp Asp Gly Gly Ala Gln Ala Leu Ala Val 
            820                 825                 830         


Thr Arg Lys Phe Leu Asn His Asp Arg Glu Ile Phe Asp Arg Tyr Cys 
        835                 840                 845             


Ala Arg Glu Ala Glu Ile Ala Arg Leu Pro Ser Glu Glu Arg Lys Pro 
    850                 855                 860                 


Leu Arg Lys Ala Asn Asp Lys Leu Leu Lys Gln Thr His Tyr Thr Asn 
865                 870                 875                 880 


His Ser Tyr Thr Tyr Ile Val Asn Asn Leu Asn Ser Phe Thr Asp Ile 
                885                 890                 895     


Asp Tyr Cys Ala Lys Asp Val Gly Leu Pro Ala Pro Asn Asp Lys Asn 
            900                 905                 910         


Asp Asn Ala Ser Ile Leu Gly Glu Met Arg Asn Asp Ile Ala His Leu 
        915                 920                 925             


Asn Val Val His Asp Met Val Lys Tyr Ile Glu Glu Leu Lys Asp Ile 
    930                 935                 940                 


Ser Ser Tyr Tyr Ala Phe Tyr Cys Tyr Val Leu Gln Arg Arg Leu Val 
945                 950                 955                 960 


Gly Asn Asp Pro Asn Cys Gln Asn Lys Phe Lys Ala Lys Tyr Ala Lys 
                965                 970                 975     


Glu Leu Asn Tyr Tyr Gly Thr Tyr Asn Lys Asn Leu Met Trp Met Leu 
            980                 985                 990         


Asn Leu Pro Phe Ala Tyr Asn Leu  Pro Arg Tyr Lys Asn  Leu Ser Ser 
        995                 1000                 1005             


Glu Phe  Leu Phe Tyr Asp Met  Glu Tyr Asn Lys Lys  Asp Asp Glu 
    1010                 1015                 1020             


<210>  3043
<211>  920
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3043

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Val Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Val Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asn Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Gly Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr Asn 
    210                 215                 220                 


Pro Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Asp Asp Tyr 
            340                 345                 350         


Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys 
        355                 360                 365             


Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met 
    370                 375                 380                 


Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val 
385                 390                 395                 400 


Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr 
                405                 410                 415     


Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg 
            420                 425                 430         


Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Thr Tyr Ala Asp Glu Ala 
        435                 440                 445             


Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp 
    450                 455                 460                 


His Met Asn Gly Asp Ala Ile Lys Glu Leu Gly Lys Ala Asp Met Asp 
465                 470                 475                 480 


Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu 
                485                 490                 495     


Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly 
            500                 505                 510         


Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn 
        515                 520                 525             


Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu 
    530                 535                 540                 


Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile 
545                 550                 555                 560 


Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro 
                565                 570                 575     


Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu 
            580                 585                 590         


Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys 
        595                 600                 605             


Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr 
    610                 615                 620                 


Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala 
625                 630                 635                 640 


Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met 
                645                 650                 655     


Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys 
            660                 665                 670         


Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg 
        675                 680                 685             


Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys 
    690                 695                 700                 


Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg 
705                 710                 715                 720 


Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val 
                725                 730                 735     


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys 
            740                 745                 750         


Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala 
        755                 760                 765             


Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys 
    770                 775                 780                 


Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg 
785                 790                 795                 800 


Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met 
                805                 810                 815     


Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu 
            820                 825                 830         


Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser 
        835                 840                 845             


Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp 
    850                 855                 860                 


Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn 
865                 870                 875                 880 


His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly 
                885                 890                 895     


Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp 
            900                 905                 910         


Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920 


<210>  3044
<211>  939
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3044

Met Ala Lys Lys Lys Thr Ala Lys Gln Leu Arg Glu Glu Gln Lys Ala 
1               5                   10                  15      


Leu Lys Met Gln Lys Ile Gln Ala Ser Val Lys Ala Lys Glu Glu Lys 
            20                  25                  30          


Lys Val Ser Glu Gln Val Pro Ala Ile Arg Lys Val Ser Gly Lys Lys 
        35                  40                  45              


Asn Lys Lys Lys Thr Tyr Ala Lys Ala Tyr Gly Ser Lys Thr Val Leu 
    50                  55                  60                  


Val Val Gly Asn Asp Val Ile Met Thr Ser Tyr Gly Glu Arg Cys Phe 
65                  70                  75                  80  


Ala Asn Leu Glu His Arg Ile Thr Pro Glu Leu Asn Ala Glu Ser Leu 
                85                  90                  95      


Ser Ser Asp Asn Ala Leu Asn Asn Ile Asp Ala Lys Asn Gly Ile Asn 
            100                 105                 110         


Ile Ser Phe Thr Gly Arg Val Ser Gly Met Thr Ala Ser Ser Asp Asn 
        115                 120                 125             


Pro Met His Val Cys Lys Thr Glu Glu Arg Lys Ala Pro Lys Pro Gly 
    130                 135                 140                 


Ile Asp Leu Leu Cys Leu Lys Asp Lys Leu Glu Gln Trp Tyr Phe Gly 
145                 150                 155                 160 


Arg Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Gln Ile Gln 
                165                 170                 175     


Asp Ile Glu Lys Ile Leu Ala Ser His Val Asn Asn Ile Val Phe Ala 
            180                 185                 190         


Leu Asp Asn Ile Leu His Glu Thr Glu Ser Glu Thr Gly Asp Phe Leu 
        195                 200                 205             


Gly Met Gly Tyr Met Arg Thr Thr Asn Ser Leu Glu Asn Tyr Lys Asp 
    210                 215                 220                 


Phe Cys Gln His Ser Ser Lys Lys Gln Val Gln Asp Ser Tyr Glu Thr 
225                 230                 235                 240 


Phe Lys Ser Tyr Ile Gln Arg Lys Glu Leu Leu Tyr Phe Gly Glu Thr 
                245                 250                 255     


Phe Tyr His Gly Asn Thr Arg Arg Asn Pro Glu Asp Ile Tyr His Ile 
            260                 265                 270         


Leu Ala Leu Val Ser Ser Leu Arg Gln Phe Cys Phe His Ser Thr Phe 
        275                 280                 285             


Asp Asp Asn Ile Lys Ser Ile Gln Gly Asn Trp Leu Tyr Cys Leu Asp 
    290                 295                 300                 


Asp Gln Leu Ser Asp Glu Phe Lys Glu Thr Leu Gly Met Leu Trp Gly 
305                 310                 315                 320 


Glu Ala Thr Glu Lys Leu Asp Arg Asp Phe Leu Lys Thr Asn Thr Val 
                325                 330                 335     


Asn Leu His Ile Leu Cys Glu Ile Phe Asp Lys Glu Lys Pro Glu Asp 
            340                 345                 350         


Ile Ile Asn Ala Tyr Tyr Glu Phe Leu Met Lys Lys Asn Phe Lys Asn 
        355                 360                 365             


Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Cys Met Leu Glu Glu Thr 
    370                 375                 380                 


Glu Leu Asn Glu Phe Lys Glu Asp Lys Tyr Asn Ser Val Arg Ser Lys 
385                 390                 395                 400 


Leu Tyr Lys Leu Phe Asp Phe Ile Leu Val His His Tyr Lys Asn Asp 
                405                 410                 415     


Ala Ser Pro Glu Ser Thr Asp Leu Gln Asn Gln Leu Arg Ala Cys Leu 
            420                 425                 430         


Thr Asp Glu Glu Lys Glu Lys Val Tyr Thr Gln Thr Ala Arg Glu Leu 
        435                 440                 445             


Thr Ala Leu Tyr Ser Tyr His Phe Lys Glu Ala Ser Val Ser Ala Asn 
    450                 455                 460                 


Ala Arg Asn Ile Lys Glu Tyr Gln Glu Lys Ala Gln Val Tyr His Ile 
465                 470                 475                 480 


Ser Ile Ala Asp Lys Ile Ser Ser Thr Gly Ile Gly Leu Phe Ser Gln 
                485                 490                 495     


Leu Ile Tyr Met Leu Thr Leu Leu Leu Asp Gly Lys Glu Ile Asn Asp 
            500                 505                 510         


Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp Asn Ile Ile Gly Phe Leu 
        515                 520                 525             


Asp Ile Leu Lys Asn Met Asn Leu Asp Ile Glu Phe Lys Lys Glu Tyr 
    530                 535                 540                 


Gln Phe Phe Asn Gln Glu Asn Cys Glu Tyr Thr Ala Lys Glu Leu Arg 
545                 550                 555                 560 


Ile Ile Asn Ser Leu Ala Arg Met Gln Lys Pro Ser Ala Asn Ala Lys 
                565                 570                 575     


Lys Val Met Phe Arg Asp Ala Leu Arg Ile Leu Gly Met Asp Asn Arg 
            580                 585                 590         


Ser Asp Glu Glu Ile Asp Lys Glu Ile Glu Arg Thr Met Pro Val Gly 
        595                 600                 605             


Ala Asp Gly Lys Phe Ile Lys Gly Lys Gln Ser Phe Arg Asn Phe Ile 
    610                 615                 620                 


Ala Ser Asn Val Ile Glu Ser Ser Arg Phe Arg Tyr Leu Val Arg Tyr 
625                 630                 635                 640 


Asn Asn Pro His Lys Thr Arg Thr Leu Val Gln Asn Arg Asn Val Val 
                645                 650                 655     


Lys Phe Val Leu Glu Gly Ile Pro Asp Thr Gln Ile Lys Arg Tyr Phe 
            660                 665                 670         


Asp Val Cys Lys Asp Lys Asp Thr Pro Asp Thr Ser Ser Lys Ser Ala 
        675                 680                 685             


Gln Ile Asp Val Leu Thr Gly Ile Leu Thr Asn Ile Asp Tyr Lys Ile 
    690                 695                 700                 


Phe Glu Asp Val Pro Gln Ser Ala Lys Ile Asn Lys Asp Asp Ala Ser 
705                 710                 715                 720 


Arg Asn Arg Val Glu Ala Leu Lys Lys Gln Arg Tyr Gln Ala Ile Ile 
                725                 730                 735     


Thr Leu Tyr Leu Thr Val Leu Tyr Leu Val Thr Lys Asn Leu Val Tyr 
            740                 745                 750         


Val Asn Ser Arg Tyr Val Met Ala Phe His Cys Leu Glu Arg Asp Ala 
        755                 760                 765             


Phe Phe Tyr Gly Ile Asp Ser Lys Lys Met Lys Glu Asp Tyr Arg Lys 
    770                 775                 780                 


Leu Thr Arg Lys Leu Leu Thr Asp Glu Thr Tyr Thr Thr Tyr Gly His 
785                 790                 795                 800 


Leu Lys Asn Gln Lys Gly His Arg Lys Trp Tyr Val Leu Val Ser Lys 
                805                 810                 815     


Asn Leu Glu Asn Ser Asp Lys Lys Ala Val His Tyr Phe Arg Asn Ile 
            820                 825                 830         


Ala Ala His Ile Ser Val Ile Arg Asn Val Asn Asp Tyr Ile Lys Asn 
        835                 840                 845             


Val Gln Glu Phe His Ser Tyr Phe Glu Leu Tyr His Tyr Leu Val Gln 
    850                 855                 860                 


Lys Met Ile Ala Glu Asn His Arg Tyr Asp Ala Lys Asn Val Lys Thr 
865                 870                 875                 880 


Ala Glu Tyr Leu Glu Asn Leu Glu Lys Tyr His Thr Tyr Ser Lys Asp 
                885                 890                 895     


Phe Val Lys Ala Tyr Cys Ile Pro Phe Gly Tyr Val Val Pro Arg Tyr 
            900                 905                 910         


Lys Asn Leu Thr Ile Asn Glu Leu Phe Asp Arg Asn Asn Pro Leu Pro 
        915                 920                 925             


Glu Pro Lys Glu Asp Lys Glu Lys Lys Glu Val 
    930                 935                 


<210>  3045
<211>  954
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3045

Met Gly Lys Lys Ile His Ala Arg Asp Leu Arg Glu Gln Arg Lys Thr 
1               5                   10                  15      


Asp Arg Thr Val Lys Phe Ala Asp Gln Asn Glu Lys Arg Glu Ala Gln 
            20                  25                  30          


Arg Ala Val Gln Lys Lys Asp Ala Ala Val Ser Val Lys Ser Val Ser 
        35                  40                  45              


Ser Val Ser Ser Lys Lys Asp Asn Val Thr Lys Ser Met Ala Lys Ala 
    50                  55                  60                  


Ala Gly Val Lys Ser Val Phe Ala Val Glu Asn Thr Val Tyr Met Thr 
65                  70                  75                  80  


Ser Phe Gly Arg Gly Asn Asp Ala Val Leu Glu Gln Lys Ile Val Asp 
                85                  90                  95      


Thr Ser His Glu Pro Leu Asn Ile Asp Asp Pro Ala Tyr Gln Leu Asn 
            100                 105                 110         


Val Val Thr Met Asn Gly Tyr Ser Val Thr Gly His Arg Gly Glu Thr 
        115                 120                 125             


Val Ser Ala Val Thr Asp Asn Pro Leu Arg Arg Phe Asn Gly Gly Lys 
    130                 135                 140                 


Lys Asp Glu Pro Glu Gln Ser Val Pro Thr Asp Met Leu Cys Leu Lys 
145                 150                 155                 160 


Pro Thr Leu Glu Lys Lys Phe Phe Gly Lys Glu Phe Asn Asp Asn Ile 
                165                 170                 175     


His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala 
            180                 185                 190         


Val Tyr Ser Thr Asn Ala Ile Tyr Ala Leu Asn Asn Met Ser Ala Asp 
        195                 200                 205             


Glu Asn Ile Glu Asn Ser Asp Phe Phe Met Lys Arg Thr Thr Asp Glu 
    210                 215                 220                 


Thr Phe Asp Asp Phe Glu Lys Lys Lys Glu Ser Thr Asn Ser Arg Glu 
225                 230                 235                 240 


Lys Ala Asp Phe Asp Ala Phe Glu Lys Phe Ile Gly Asn Tyr Arg Leu 
                245                 250                 255     


Ala Tyr Phe Ala Asp Ala Phe Tyr Val Asn Lys Lys Asn Pro Lys Gly 
            260                 265                 270         


Lys Ala Arg Asn Val Leu Arg Glu Asp Lys Glu Leu Tyr Ser Val Leu 
        275                 280                 285             


Thr Leu Ile Gly Lys Leu Arg His Trp Cys Val His Ser Glu Asp Gly 
    290                 295                 300                 


Arg Ala Glu Phe Trp Leu Tyr Lys Leu Asn Glu Leu Lys Asp Asp Phe 
305                 310                 315                 320 


Lys Asn Val Leu Asp Val Val Tyr Asn Arg Pro Val Glu Glu Ile Asn 
                325                 330                 335     


Asn Arg Phe Ile Glu Asn Asn Lys Val Asn Ile Gln Ile Leu Gly Ser 
            340                 345                 350         


Val Tyr Lys Asn Thr Asp Ile Ala Glu Leu Val Arg Ser Tyr Tyr Glu 
        355                 360                 365             


Phe Leu Ile Thr Lys Lys Tyr Lys Asn Met Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Ser Met Phe Glu Gly Lys Gly Tyr Ala Asp Lys Glu Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Asn Lys Leu Tyr Gln Met Thr Asp Phe Ile Leu Tyr 
                405                 410                 415     


Thr Gly Tyr Ile Asn Glu Asp Ser Asp Arg Ala Asp Asp Leu Val Asn 
            420                 425                 430         


Thr Leu Arg Ser Ser Leu Lys Glu Asp Asp Lys Thr Thr Val Tyr Cys 
        435                 440                 445             


Lys Glu Ala Asp Tyr Leu Trp Lys Lys Tyr Arg Glu Ser Ile Arg Glu 
    450                 455                 460                 


Val Ala Asp Ala Leu Asp Gly Asp Asn Ile Lys Lys Leu Ser Lys Ser 
465                 470                 475                 480 


Asn Ile Glu Ile Gln Glu Asp Lys Leu Arg Lys Cys Phe Ile Ser Tyr 
                485                 490                 495     


Ala Asp Ser Val Ser Glu Phe Thr Lys Leu Ile Tyr Leu Leu Thr Arg 
            500                 505                 510         


Phe Leu Ser Gly Lys Glu Ile Asn Asp Leu Val Thr Thr Leu Ile Asn 
        515                 520                 525             


Lys Phe Asp Asn Ile Arg Ser Phe Leu Glu Ile Met Asp Glu Leu Gly 
    530                 535                 540                 


Leu Asp Arg Thr Phe Thr Ala Glu Tyr Ser Phe Phe Glu Gly Ser Thr 
545                 550                 555                 560 


Lys Tyr Leu Ala Glu Leu Ile Glu Leu Asn Ser Phe Val Lys Ser Cys 
                565                 570                 575     


Ser Phe Asp Ile Asn Ala Lys Arg Thr Met Tyr Arg Asp Ala Leu Asp 
            580                 585                 590         


Ile Leu Gly Ile Glu Ser Gly Lys Thr Glu Glu Asp Ile Glu Lys Met 
        595                 600                 605             


Ile Asp Asn Ile Leu Gln Ile Asp Ala Asn Gly Asp Lys Lys Leu Lys 
    610                 615                 620                 


Lys Asn Asn Gly Leu Arg Asn Phe Ile Ala Ser Asn Val Ile Asp Ser 
625                 630                 635                 640 


Asn Arg Phe Lys Tyr Leu Val Arg Tyr Gly Asn Pro Lys Lys Ile Arg 
                645                 650                 655     


Glu Thr Ala Lys Cys Glu Pro Ala Val Arg Phe Val Leu Asn Glu Ile 
            660                 665                 670         


Pro Asp Ala Gln Ile Glu Arg Tyr Tyr Glu Ala Cys Cys Pro Lys Asn 
        675                 680                 685             


Thr Ala Leu Cys Ser Ala Asn Lys Arg Arg Glu Lys Leu Ala Asp Met 
    690                 695                 700                 


Ile Ala Glu Ile Glu Phe Glu Asn Phe Ser Asp Ala Gly Asn Tyr Gln 
705                 710                 715                 720 


Lys Ala Asn Val Thr Ser Arg Thr His Glu Ala Glu Ile Lys Arg Lys 
                725                 730                 735     


Asn Gln Ala Ile Ile Arg Leu Tyr Leu Thr Val Met Tyr Ile Met Leu 
            740                 745                 750         


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Phe His Cys 
        755                 760                 765             


Val Glu Arg Asp Thr Lys Leu Tyr Ala Glu Ser Gly Leu Glu Val Gly 
    770                 775                 780                 


Asn Ile Glu Lys Asn Lys Thr Asn Leu Thr Met Ala Val Met Gly Val 
785                 790                 795                 800 


Lys Leu Glu Asn Gly Ile Ile Lys Thr Glu Phe Asp Lys Ser Leu Ala 
                805                 810                 815     


Glu Asn Ala Ala Asn Arg Tyr Leu Arg Asn Ala Arg Trp Tyr Lys Leu 
            820                 825                 830         


Ile Leu Asp Asn Leu Lys Lys Ser Glu Arg Ala Val Val Asn Glu Phe 
        835                 840                 845             


Arg Asn Thr Val Cys His Leu Asn Ala Ile Arg Asn Ile Asn Ile Asn 
    850                 855                 860                 


Ile Lys Glu Ile Lys Glu Val Glu Asn Tyr Phe Ala Leu Tyr His Tyr 
865                 870                 875                 880 


Leu Ile Gln Lys His Leu Glu Asn Arg Phe Ala Asp Lys Lys Val Glu 
                885                 890                 895     


Arg Asp Thr Gly Asp Phe Ile Ser Lys Leu Glu Glu His Lys Thr Tyr 
            900                 905                 910         


Cys Lys Asp Phe Val Lys Ala Tyr Cys Thr Pro Phe Gly Tyr Asn Leu 
        915                 920                 925             


Val Arg Tyr Lys Asn Leu Thr Ile Asp Gly Leu Phe Asp Lys Asn Tyr 
    930                 935                 940                 


Pro Gly Lys Asp Asp Ser Asp Glu Gln Lys 
945                 950                 


<210>  3046
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3046

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Ile Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Pro Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn His Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3047
<211>  939
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3047

Met Ala Lys Lys Lys Arg Ile Thr Ala Lys Glu Arg Lys Gln Asn His 
1               5                   10                  15      


Arg Glu Leu Leu Met Lys Lys Ala Asp Ser Asn Ala Glu Lys Glu Lys 
            20                  25                  30          


Ala Lys Lys Pro Val Val Glu Asn Lys Pro Asp Thr Ala Ile Ser Lys 
        35                  40                  45              


Asp Asn Thr Pro Lys Pro Asn Lys Glu Ile Lys Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Ala Gly Val Lys Trp Val Ile Lys Ala Asn Asp Asp Val Ala Tyr 
65                  70                  75                  80  


Ile Ser Ser Phe Gly Lys Gly Asn Asn Ser Val Leu Glu Lys Arg Ile 
                85                  90                  95      


Met Gly Asp Val Ser Ser Asn Val Asn Lys Asp Ser His Met Tyr Val 
            100                 105                 110         


Asn Pro Lys Tyr Thr Lys Lys Asn Tyr Glu Ile Lys Asn Gly Phe Ser 
        115                 120                 125             


Ser Gly Ser Ser Leu Val Thr Tyr Pro Asn Lys Pro Asp Lys Asn Ser 
    130                 135                 140                 


Gly Met Asp Ala Leu Cys Leu Lys Pro Tyr Phe Glu Lys Asp Phe Phe 
145                 150                 155                 160 


Gly His Ile Phe Thr Asp Asn Met His Ile Gln Ala Ile Tyr Asn Ile 
                165                 170                 175     


Phe Asp Ile Glu Lys Ile Leu Ala Lys His Ile Thr Asn Ile Ile Tyr 
            180                 185                 190         


Thr Val Asn Ser Phe Asp Arg Asn Tyr Asn Gln Ser Gly Asn Asp Thr 
        195                 200                 205             


Ile Gly Phe Gly Leu Asn Tyr Arg Val Pro Tyr Ser Glu Tyr Gly Gly 
    210                 215                 220                 


Gly Lys Asp Ser Asn Gly Glu Pro Lys Asn Lys Phe Lys Trp Glu Lys 
225                 230                 235                 240 


Arg Asp Asn Phe Ser Lys Phe Tyr Asn Glu Ser Lys Pro His Leu Gly 
                245                 250                 255     


Tyr Tyr Glu Asn Ile Phe Tyr Asp His Gly Glu Pro Ile Ser Glu Glu 
            260                 265                 270         


Lys Phe Tyr Asn Tyr Leu Asn Ile Leu Asn Phe Ile Arg Asn Asn Thr 
        275                 280                 285             


Phe His Tyr Lys Asp Asn Asp Ile Glu Leu Tyr Ser Glu Asn Tyr Ser 
    290                 295                 300                 


Glu Glu Tyr Val Phe Ile Asn Cys Leu Asn Lys Phe Val Lys Asn Lys 
305                 310                 315                 320 


Phe Lys Asn Val Asn Lys Asn Phe Ile Ser Asn Glu Lys Asn Asn Leu 
                325                 330                 335     


Tyr Ile Ile Leu Asn Ala Tyr Gly Lys Asp Thr Glu Asn Val Glu Val 
            340                 345                 350         


Val Lys Lys Tyr Ser Lys Glu Leu Tyr Lys Leu Ser Val Leu Lys Thr 
        355                 360                 365             


Asn Lys Asn Leu Gly Val Asn Val Lys Lys Leu Arg Glu Ser Ala Ile 
    370                 375                 380                 


Glu Tyr Gly Tyr Cys Pro Leu Pro Tyr Asp Lys Glu Lys Glu Val Ala 
385                 390                 395                 400 


Lys Leu Ser Ser Val Lys His Lys Leu Tyr Lys Thr Tyr Asp Phe Val 
                405                 410                 415     


Ile Thr His Tyr Leu Asn Ser Asn Asp Lys Ile Leu Leu Glu Ile Val 
            420                 425                 430         


Glu Ala Leu Arg Leu Ser Lys Asn Asp Asp Glu Lys Glu Asn Val Tyr 
        435                 440                 445             


Lys Lys Tyr Ala Glu Lys Leu Phe Lys Ala Asp Asp Val Ile Asn Pro 
    450                 455                 460                 


Ile Lys Ala Ile Ser Lys Leu Phe Val Glu Lys Gly Asn Lys Leu Phe 
465                 470                 475                 480 


Lys Glu Lys Ile Ile Ile Lys Lys Glu Tyr Ile Glu Asp Val Ser Ile 
                485                 490                 495     


Asp Lys Asn Ile Tyr Asp Phe Thr Lys Val Ile Phe Phe Met Thr Cys 
            500                 505                 510         


Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Asn Ile Ile Ser 
        515                 520                 525             


Lys Leu Gln Ile Ile Glu Asp His Asn Asn Val Ile Lys Phe Ile Ser 
    530                 535                 540                 


His Asn Lys Asp Ala Val Tyr Lys Asp Tyr Ser Asp Lys Tyr Ala Ile 
545                 550                 555                 560 


Phe Arg Asn Ala Gly Lys Ile Ala Thr Glu Leu Glu Ala Ile Lys Ser 
                565                 570                 575     


Ile Ala Arg Met Glu Asn Lys Ile Glu Asn Ala Ser Gln Glu Pro Leu 
            580                 585                 590         


Leu Asn Asp Ala Leu Leu Ser Leu Gly Val Ser Asp Asp Thr Lys Val 
        595                 600                 605             


Leu Glu Asn Thr Tyr Lys Lys Tyr Phe Asp Ser Lys Glu Lys Thr Asp 
    610                 615                 620                 


Lys Gln Ser Gln Lys Val Ser Thr Phe Leu Met Asn Asn Val Ile Asn 
625                 630                 635                 640 


Asn Asn Arg Phe Lys Tyr Val Ile Lys Tyr Ile Asn Pro Ala Asp Ile 
                645                 650                 655     


Asn Gly Leu Ala Lys Asn Arg Tyr Leu Val Lys Phe Val Leu Ser Lys 
            660                 665                 670         


Ile Pro Glu Glu Gln Ile Asp Ser Tyr Tyr Lys Leu Phe Ser Asn Glu 
        675                 680                 685             


Glu Glu Pro Gly Cys Glu Glu Lys Ile Lys Leu Leu Thr Lys Lys Ile 
    690                 695                 700                 


Ser Lys Leu Asn Phe Gln Thr Leu Phe Glu Asn Asn Lys Ile Pro Asn 
705                 710                 715                 720 


Val Glu Lys Glu Lys Lys Lys Ala Ile Ile Thr Leu Tyr Phe Thr Ile 
                725                 730                 735     


Val Tyr Ile Leu Val Lys Asn Leu Val Asn Ile Asn Gly Leu Tyr Thr 
            740                 745                 750         


Leu Ala Leu Tyr Phe Val Glu Arg Asp Gly Tyr Phe Tyr Lys Asp Ile 
        755                 760                 765             


Cys Gly Lys Lys Asp Lys Lys Lys Ser Tyr Asn Asp Val Asp Tyr Leu 
    770                 775                 780                 


Leu Leu Pro Glu Ile Phe Ser Gly Ser Lys Tyr Arg Glu Glu Thr Lys 
785                 790                 795                 800 


Asn Leu Lys Leu Pro Lys Glu Lys Asp Arg Asp Ile Met Lys Lys Tyr 
                805                 810                 815     


Leu Pro Asn Asp Lys Asp Arg Glu Lys Tyr Asn Lys Phe Phe Thr Ala 
            820                 825                 830         


Tyr Arg Asn Asn Ile Val His Leu Asn Ile Ile Ala Lys Leu Ser Glu 
        835                 840                 845             


Leu Thr Lys Asn Ile Asp Lys Asp Ile Asn Ser Tyr Phe Asp Ile Tyr 
    850                 855                 860                 


His Tyr Cys Thr Gln Arg Val Met Phe Asn Tyr Cys Lys Glu Lys Asn 
865                 870                 875                 880 


Asp Val Val Leu Ala Lys Met Lys Asp Leu Ala His Ile Lys Ser Asp 
                885                 890                 895     


Cys Asn Glu Phe Ser Ser Lys His Thr Tyr Pro Phe Ser Ser Ala Val 
            900                 905                 910         


Leu Arg Phe Met Asn Leu Pro Phe Ala Tyr Asn Val Pro Arg Phe Lys 
        915                 920                 925             


Asn Leu Ser Tyr Lys Lys Phe Phe Asp Lys Gln 
    930                 935                 


<210>  3048
<211>  921
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3048

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Gly Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Asn Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu Tyr Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Val Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp 
    370                 375                 380                 


Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Ile Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Glu Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn Arg 
785                 790                 795                 800 


Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser 
                805                 810                 815     


Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg 
            820                 825                 830         


Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe 
        835                 840                 845             


Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp 
    850                 855                 860                 


Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys 
865                 870                 875                 880 


Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe 
                885                 890                 895     


Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe 
            900                 905                 910         


Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920     


<210>  3049
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3049

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asp Asn Asp Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Gln Asn Thr Tyr Tyr Ile 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val 
            260                 265                 270         


Ser Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu 
    290                 295                 300                 


Tyr Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Val Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3050
<211>  975
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3050

Met Met Gly Lys His Leu Asn Ala Lys Gln Arg Glu Leu Glu Lys Lys 
1               5                   10                  15      


Leu Lys Asn Gln Gln Lys Gly Met Met Tyr Asn Lys Ser Thr Asp Ala 
            20                  25                  30          


Val Ser Val Pro Thr Leu Gln Ala Ala Pro Lys Lys Ala Ala Glu Ala 
        35                  40                  45              


Ser Thr Leu Ile Thr Pro Gly Thr Leu Lys Thr Lys Ala Lys Ala Met 
    50                  55                  60                  


Gly Leu Lys Ser Thr Leu Val Phe Asp Asp Lys Ile Val Val Thr Ser 
65                  70                  75                  80  


Phe Leu Asn Ser Lys Thr Glu Glu Asn Glu Lys Cys Ala His Ile Glu 
                85                  90                  95      


Lys Ile Thr Asp Cys Asn Gly Gln Thr Ile Val Glu Arg Pro Arg Met 
            100                 105                 110         


Phe Asn Thr Ser Ile Asn Ala Gln Gln Val Asp Leu Ser Lys Asp Asn 
        115                 120                 125             


Asp Glu Thr Asn Tyr Pro Asn Pro Ala Phe Glu Asp Cys Gly Arg Asp 
    130                 135                 140                 


Tyr Ile Asn Ile Lys Ser Ala Leu Glu Lys Arg Val Phe Gly Lys Thr 
145                 150                 155                 160 


Tyr Asn Lys Asp Asn Leu His Val Gln Ile Ala Tyr Asn Ile Phe Asp 
                165                 170                 175     


Ile Lys Lys Ile Ile Gly Thr Tyr Ile Asn Asn Ile Thr Tyr Ile Phe 
            180                 185                 190         


Tyr Asn Leu Gly Arg Glu Glu Tyr Asn Ala Lys Lys Asp Ile Ile Gly 
        195                 200                 205             


Asn Gln Asp Ser Asp Tyr Ile Asn Lys Leu Leu Asn Asn Thr Ser Ala 
    210                 215                 220                 


Tyr Phe Thr Tyr Phe Asp Gly Val Phe Lys Gln Ile Thr Asp Arg Asp 
225                 230                 235                 240 


Ser Asn Lys Asp Arg Glu Val Lys Asn Ser Tyr Asn Ala Leu Val Leu 
                245                 250                 255     


Lys Val Leu Tyr Tyr Leu Arg Gln Phe Cys Met His Gly Asn Thr Tyr 
            260                 265                 270         


Thr Lys Arg Asn Glu Glu Ser Phe Leu Ser Asp Thr Ala Leu Tyr Asn 
        275                 280                 285             


Val Lys Asp Phe Phe Ala Lys Ala Asp Pro Gln Ile Asn Glu Leu Ile 
    290                 295                 300                 


Asp Ala Val Tyr Ala Asp Gly Ile Lys Thr Ile Asn Asn Asp Phe Met 
305                 310                 315                 320 


Ala His Ala Lys Asn Asn Met Tyr Ile Ile Cys Glu Val Tyr Lys Asn 
                325                 330                 335     


Glu Val Glu Asp Ser Leu Met Lys Glu Tyr Tyr Asp Phe Val Val Arg 
            340                 345                 350         


Lys Glu Gly Asn Asn Leu Gly Phe Asn Thr Arg Gln Leu Arg Glu Ile 
        355                 360                 365             


Leu Ile Asp Lys Tyr Val Gly Asn Leu Arg Asp Lys Lys Tyr Asp Thr 
    370                 375                 380                 


Phe Arg Asn Lys Leu Tyr Thr Val Leu Gly Phe Ile Leu Val Lys Glu 
385                 390                 395                 400 


Ile Lys Arg Asn Pro Lys Ile Gln Asp Ser Phe Ile Ala Lys Leu Arg 
                405                 410                 415     


Ala Asn Gln Ser Gly Asp Glu Gly Lys Leu Lys Ile Tyr Asn Glu Phe 
            420                 425                 430         


Ala Pro Lys Ile Trp Ser Val Val Ser Ser Lys Phe Asn Ser Ala Ile 
        435                 440                 445             


Thr Cys Phe Asp Glu Glu Ser Leu Ser Lys Phe Lys Gly Tyr Lys Asp 
    450                 455                 460                 


Ile Asp Glu Ser Leu Ile Ser Arg Tyr Gly Ile Thr Val Ser Asn Thr 
465                 470                 475                 480 


Asp Thr Leu Val Lys Ile Leu Tyr Phe Leu Cys Lys Phe Leu Asp Gly 
                485                 490                 495     


Lys Glu Ile Asn Glu Leu Cys Cys Ala Met Ile Asn Lys Phe Asp Asn 
            500                 505                 510         


Ile Asn Asp Leu Ile Lys Thr Ala Ala Gln Cys Gly Glu Asp Ile Glu 
        515                 520                 525             


Phe Val Lys Glu Tyr Lys Leu Phe Ile Asn Ser Lys Asp Ile Ser Asp 
    530                 535                 540                 


Gln Ile Arg Val Val Lys Ser Ile Ser Lys Met Lys Pro Glu Leu Ser 
545                 550                 555                 560 


Asn Ile Gly Glu Val Leu Leu Leu Asp Ala Ile Asp Ile Leu Gly Tyr 
                565                 570                 575     


Lys Ile Asn Lys Tyr Lys Cys Asp Ala Asp Gly Asn Arg Leu Val Asp 
            580                 585                 590         


Ser Asn Asn Lys Pro Val Tyr Ser Glu Glu Tyr Cys Thr Phe Lys Lys 
        595                 600                 605             


Asp Phe Phe Glu Thr Cys Glu Leu Asp Glu Phe Gly Arg Val Lys Tyr 
    610                 615                 620                 


Asp Lys Lys Gly Lys Pro Val Ile Asn His Arg Arg Arg Asn Phe Ile 
625                 630                 635                 640 


Ile Asn Asn Val Leu Ser Ser Lys Trp Phe Phe Tyr Val Ala Lys Tyr 
                645                 650                 655     


Asn Arg Pro Ser Glu Cys Gln Lys Phe Met Lys Ser Lys Lys Leu Ile 
            660                 665                 670         


Ala Leu Ala Leu Lys Asp Val Pro Glu Thr Gln Ile Ala Arg Tyr Tyr 
        675                 680                 685             


His Ser Val Thr Gly Gly Arg Glu Gln Thr Asp Ser Glu Ala Met Arg 
    690                 695                 700                 


Thr Thr Leu Ile Ser Arg Leu His Glu Phe Ser Ile Lys Asp Val Leu 
705                 710                 715                 720 


Ser Ser Val Gly Ser Met Thr Ala Ser Glu Asn Lys Arg Gln Ile Glu 
                725                 730                 735     


Asn Ser Arg Lys Glu Gln Met Lys Ala Ile Val Lys Leu Tyr Leu Thr 
            740                 745                 750         


Val Val Tyr Leu Ile Ala Lys Ser Leu Val Lys Val Asn Thr Arg Phe 
        755                 760                 765             


Ser Ile Ala Phe Ser Ala Tyr Glu Arg Asp Val Ser Leu Leu Ala Asp 
    770                 775                 780                 


Glu Asn Glu Ser Ile Ala Leu Ala Asp Asn Asp Asp Asp Lys Trp Lys 
785                 790                 795                 800 


Thr Gly Asn Tyr Ile Phe Ala Leu Thr Lys His Phe Leu Asp Asn Asp 
                805                 810                 815     


Glu Pro Tyr Phe Asp Lys Tyr Asn Asn Ala Leu Gln Gln Ile Lys Gly 
            820                 825                 830         


Ile Thr Asp Pro Asn Glu Arg Arg Leu Ala Tyr Arg Ala Asn Asp Lys 
        835                 840                 845             


Val Ile Lys His Thr His Phe Asn Leu His Thr Asn Lys Tyr Val Lys 
    850                 855                 860                 


Asp Asn Tyr Glu Lys Ile Ser Lys Met Asn Lys Ile Val Thr Glu Tyr 
865                 870                 875                 880 


Arg Asn Asn Val Gln His Leu Ala Val Val Asn Asn Ile Thr Lys Tyr 
                885                 890                 895     


Leu Gly Asp Ile Ser Glu Val Thr Ser Tyr Tyr Ser Leu Tyr Cys Tyr 
            900                 905                 910         


Ile Leu Gln Arg Leu Leu Leu Asp Asn Asn Asn Asn Asp Lys Phe Ala 
        915                 920                 925             


Glu Ile Lys Glu Lys Leu Ile Lys Phe Gly Thr Tyr Asn Lys Asp Phe 
    930                 935                 940                 


Met Trp Leu Ile Asn Val Pro Phe Ala Tyr Asn Leu Pro Arg Tyr Lys 
945                 950                 955                 960 


Asn Leu Ser Asn Glu Glu Ile Phe Tyr Asp Val Ile Gln Asn Lys 
                965                 970                 975 


<210>  3051
<211>  921
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3051

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Gly Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Asn Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu Tyr Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Val Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp 
    370                 375                 380                 


Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Ile Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Glu Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn Arg 
785                 790                 795                 800 


Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser 
                805                 810                 815     


Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg 
            820                 825                 830         


Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe 
        835                 840                 845             


Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp 
    850                 855                 860                 


Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys 
865                 870                 875                 880 


Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe 
                885                 890                 895     


Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe 
            900                 905                 910         


Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920     


<210>  3052
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3052

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Lys Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asn Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Asp Glu Ser His Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe Thr Asp 
    210                 215                 220                 


Pro Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Asn Ala Leu Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Pro Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp Asp Ile 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  3053
<211>  924
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3053

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asn Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Leu Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Leu Ser Glu His Ser Glu Tyr Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asp Asn Ser Lys Lys Val Tyr Arg Glu Cys Arg Glu Thr Leu 
305                 310                 315                 320 


Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile 
                325                 330                 335     


Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly 
            340                 345                 350         


Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu 
        355                 360                 365             


Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys 
    370                 375                 380                 


Ile Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser 
385                 390                 395                 400 


Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn 
                405                 410                 415     


Tyr Tyr Arg Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu 
            420                 425                 430         


Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu 
        435                 440                 445             


Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala 
    450                 455                 460                 


Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met 
465                 470                 475                 480 


Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp 
                485                 490                 495     


Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp 
            500                 505                 510         


Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp 
        515                 520                 525             


Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val 
    530                 535                 540                 


Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg 
545                 550                 555                 560 


Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys 
                565                 570                 575     


Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile 
            580                 585                 590         


Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu 
        595                 600                 605             


Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile 
    610                 615                 620                 


Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr 
625                 630                 635                 640 


Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val 
                645                 650                 655     


Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr 
            660                 665                 670         


Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys 
        675                 680                 685             


Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe 
    690                 695                 700                 


Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu 
705                 710                 715                 720 


Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu 
                725                 730                 735     


Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His 
            740                 745                 750         


Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu 
        755                 760                 765             


Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu 
    770                 775                 780                 


Cys Glu Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys 
785                 790                 795                 800 


Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala 
                805                 810                 815     


Asp Ser Asn Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr 
            820                 825                 830         


Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp 
        835                 840                 845             


Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys 
    850                 855                 860                 


Arg Glu Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp 
865                 870                 875                 880 


Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn 
                885                 890                 895     


Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu 
            900                 905                 910         


Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 


<210>  3054
<211>  984
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3054

Met Lys Lys Lys Asn Ile Arg Ala Thr Arg Glu Ala Leu Lys Ala Gln 
1               5                   10                  15      


Lys Ile Lys Lys Ser Gln Glu Asn Glu Ala Leu Lys Lys Gln Lys Leu 
            20                  25                  30          


Ala Glu Glu Ala Ala Gln Lys Arg Arg Glu Glu Leu Glu Lys Lys Asn 
        35                  40                  45              


Leu Ala Gln Trp Glu Glu Thr Ser Ala Glu Gly Arg Arg Ser Arg Val 
    50                  55                  60                  


Lys Ala Val Gly Val Lys Ser Val Phe Val Val Gly Asp Asp Leu Tyr 
65                  70                  75                  80  


Leu Ala Thr Phe Gly Asn Gly Asn Glu Thr Val Leu Glu Lys Lys Ile 
                85                  90                  95      


Thr Pro Asp Gly Lys Ile Thr Thr Phe Pro Glu Glu Glu Thr Phe Thr 
            100                 105                 110         


Ala Lys Leu Lys Phe Ala Lys Thr Glu Leu Thr Glu Ala Thr Ser Ile 
        115                 120                 125             


Gly Ile Ser Asn Gly Arg Ile Val Leu Pro Glu Ile Ser Val Asp Asn 
    130                 135                 140                 


Pro Leu His Thr Thr Met Gln Lys Asn Thr Ile Lys Lys Ser Ala Gly 
145                 150                 155                 160 


Glu Asp Met Leu Gln Leu Lys Asp Val Leu Glu Asn Arg Tyr Phe Asp 
                165                 170                 175     


Arg Ser Phe Asn Asn Asp Leu His Ile Arg Leu Ile Tyr Asn Ile Leu 
            180                 185                 190         


Asp Ile Glu Lys Ile Leu Ala Glu Tyr Thr Thr Asn Ala Val Phe Ala 
        195                 200                 205             


Ile Asp Asn Val Ser Gly Cys Ser Asp Asp Phe Leu Ser Asn Phe Ser 
    210                 215                 220                 


Thr Arg Asn Gln Trp Asp Glu Phe Gln Asn Pro Glu Gln His Arg Glu 
225                 230                 235                 240 


His Phe Gly Asn Lys Asp Asn Val Ile Cys Ser Val Lys Lys Gln Gln 
                245                 250                 255     


Asp Leu Phe Phe Asn Phe Phe Lys Asn Asn Arg Ile Gly Tyr Phe Gly 
            260                 265                 270         


Lys Ala Phe Phe His Ala Glu Ser Glu Arg Lys Ile Val Lys Lys Thr 
        275                 280                 285             


Ala Lys Glu Val Tyr His Ile Leu Thr Leu Ile Gly Ser Leu Arg Gln 
    290                 295                 300                 


Trp Ile Thr His Ser Thr Glu Gly Gly Ile Ser Arg Leu Trp Leu Tyr 
305                 310                 315                 320 


Gln Leu Glu Asp Ala Leu Ser Ser Glu Tyr Gln Glu Thr Met Asn Asn 
                325                 330                 335     


Cys Tyr Asn Ser Thr Ile Tyr Gly Leu Gln Lys Asp Phe Glu Lys Thr 
            340                 345                 350         


Asn Ala Pro Asn Leu Asn Phe Leu Ala Glu Ile Leu Gly Lys Asn Ala 
        355                 360                 365             


Ser Glu Leu Ala Glu Pro Tyr Phe Arg Phe Ile Ile Thr Lys Glu Tyr 
    370                 375                 380                 


Lys Asn Leu Gly Phe Ser Ile Lys Thr Leu Arg Glu Met Leu Leu Asp 
385                 390                 395                 400 


Gln Pro Asp Leu Gln Glu Ile Arg Glu Asn His Asn Val Tyr Asp Ser 
                405                 410                 415     


Ile Arg Ser Lys Leu Tyr Lys Met Met Asp Phe Val Leu Val Tyr Ala 
            420                 425                 430         


Tyr Ser Asn Glu Arg Lys Ser Lys Ala Asp Ala Leu Ala Ser Asn Leu 
        435                 440                 445             


Arg Ser Ala Ile Thr Glu Asp Ala Lys Lys Arg Val Tyr Gln Asn Glu 
    450                 455                 460                 


Ala Asp Gln Leu Trp Thr Ser Tyr Gln Glu Leu Phe Lys Arg Ile Arg 
465                 470                 475                 480 


Gly Phe Lys Gly Ala Gln Val Lys Glu Tyr Ser Ser Gln Asn Met Pro 
                485                 490                 495     


Ile Pro Ile Gln Lys Gln Ile Gln Asn Ile Leu Lys Pro Ala Glu Gln 
            500                 505                 510         


Val Thr Cys Phe Thr Lys Leu Met Tyr Leu Leu Thr Met Phe Leu Asp 
        515                 520                 525             


Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp 
    530                 535                 540                 


Asn Ile Ser Ser Leu Leu Lys Thr Met Glu Gln Leu Glu Leu Gln Thr 
545                 550                 555                 560 


Thr Phe Lys Glu Asp Tyr Thr Phe Phe Gln Gln Ser Ser Cys Leu Cys 
                565                 570                 575     


Glu Glu Ile Thr Gln Leu Lys Ser Phe Ala Arg Met Gly Asn Pro Ile 
            580                 585                 590         


Ser Asn Leu Lys Glu Val Met Met Val Asp Ala Ile Gln Ile Leu Gly 
        595                 600                 605             


Thr Glu Lys Ser Glu Gln Glu Leu Gln Ser Met Ala Cys Phe Phe Phe 
    610                 615                 620                 


Arg Asp Lys Asn Gly Lys Lys Leu Asn Ala Gly Glu His Gly Met Arg 
625                 630                 635                 640 


Asn Phe Ile Gly Asn Asn Val Ile Ser Asn Thr Arg Phe Gln Tyr Leu 
                645                 650                 655     


Ile Arg Tyr Gly Asn Pro Gln Lys Leu His Thr Leu Ser Gln Asn Glu 
            660                 665                 670         


Thr Val Val Arg Phe Val Leu Ser Arg Ile Ala Lys Asn Gln Arg Val 
        675                 680                 685             


Gln Gly Met Asn Gly Lys Asn Gln Ile Asp Arg Tyr Tyr Glu Thr Cys 
    690                 695                 700                 


Gly Gly Thr Asn Ser Trp Ser Val Ser Glu Glu Glu Lys Ile Asn Phe 
705                 710                 715                 720 


Leu Cys Lys Ile Leu Thr Asn Met Ser Tyr Asp Gln Phe Gln Asp Val 
                725                 730                 735     


Lys Gln Ser Asp Lys Ile Ile Thr Ala Glu Glu Lys Arg Lys Lys Glu 
            740                 745                 750         


Arg Tyr Lys Ala Ile Ile Ser Leu Tyr Leu Thr Val Leu Tyr Gln Leu 
        755                 760                 765             


Ile Lys Asn Leu Val Asn Ile Asn Ala Arg Tyr Ile Ile Ala Phe His 
    770                 775                 780                 


Cys Leu Glu Arg Asp Ala Ile Leu Tyr Ser Leu Lys Phe Asn Thr Ser 
785                 790                 795                 800 


Ile Asn Leu Lys Lys Arg Tyr Thr Ala Leu Thr Glu Met Ile Leu Gly 
                805                 810                 815     


Tyr Glu Thr Asp Glu Lys Ala Arg Arg Lys Asp Thr Arg Thr Ile Tyr 
            820                 825                 830         


Glu Lys Ala Glu Ala Ala Lys Asn Arg His Leu Lys Asn Val Lys Trp 
        835                 840                 845             


Asn Cys Lys Thr Arg Glu Asn Leu Glu Asn Ala Asp Lys Asn Ala Ile 
    850                 855                 860                 


Val Ala Phe Arg Asn Ile Val Ala His Leu Trp Ile Ile Arg Asp Ala 
865                 870                 875                 880 


Asp Arg Phe Ile Thr Glu Met Gly Ala Met Lys Arg Tyr Phe Asp Cys 
                885                 890                 895     


Tyr His Tyr Leu Leu Gln Arg Glu Leu Glu Tyr Ile Leu Glu Lys Ser 
            900                 905                 910         


Asn Gln Gly Ser Lys Tyr Thr Lys Lys Ser Leu Glu Lys Val Gln Gln 
        915                 920                 925             


Tyr His Ser Tyr Cys Lys Asp Phe Leu His Met Leu Cys Leu Pro Phe 
    930                 935                 940                 


Ala Tyr Cys Ile Pro Arg Tyr Lys Asn Leu Ser Ile Ala Glu Leu Phe 
945                 950                 955                 960 


Asp Arg His Glu Leu Glu Ala Glu Pro Lys Glu Glu Ala Ser Pro Ala 
                965                 970                 975     


Asn Asn Ser Gln Phe Ile Thr Thr 
            980                 


<210>  3055
<211>  930
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3055

Met Gln Lys Lys Lys Lys Gln Lys Lys Pro Val Val Glu Asn Lys Pro 
1               5                   10                  15      


Asp Thr Ala Ile Ser Lys Asp Asn Thr Pro Lys Pro Asn Lys Glu Ile 
            20                  25                  30          


Lys Lys Ser Lys Ala Lys Leu Ala Gly Val Lys Trp Val Ile Lys Ala 
        35                  40                  45              


Asn Asp Asp Val Ala Tyr Ile Ser Ser Phe Gly Lys Gly Asn Asn Ser 
    50                  55                  60                  


Val Leu Glu Lys Arg Ile Ile Gly Asp Val Ser Ser Asp Val Asn Lys 
65                  70                  75                  80  


Asp Ser His Met Tyr Val Asn Pro Lys Tyr Thr Lys Lys Asn Tyr Glu 
                85                  90                  95      


Ile Lys Asn Gly Phe Ser Ser Gly Ser Ser Leu Thr Thr His Pro Asn 
            100                 105                 110         


Lys Pro Asp Lys Asn Ser Gly Met Asp Ala Leu Cys Leu Lys Ile Tyr 
        115                 120                 125             


Phe Glu Lys Glu Ile Phe Lys Asp Lys Phe Asn Asp Asn Met His Ile 
    130                 135                 140                 


Gln Thr Ile Tyr Asn Ile Phe Asp Ile Glu Lys Thr Leu Ala Lys His 
145                 150                 155                 160 


Ile Thr Asn Ile Ile Tyr Ala Val Asn Ser Leu Asp Arg Ser Tyr Ile 
                165                 170                 175     


Gln Ser Gly Asn Asp Thr Ile Gly Phe Gly Leu Asn Tyr Arg Ile Pro 
            180                 185                 190         


Tyr Ala Lys Tyr Gly Arg Gly Lys Asp Ser Asn Gly Lys Pro Asn Asn 
        195                 200                 205             


Ser Asn Leu Lys Lys Arg Glu Ser Phe Ile Lys Phe Tyr Asn Asn Ala 
    210                 215                 220                 


Lys Asp Arg Phe Gly Tyr Phe Glu Ser Val Phe Tyr Gln Asn Gly Lys 
225                 230                 235                 240 


Pro Ile Ser Arg Glu Lys Leu Tyr Ile Tyr Leu Asn Ile Leu Asn Phe 
                245                 250                 255     


Val Arg Asn Ser Thr Phe His Tyr Asn Asn Thr Ser Thr Tyr Leu Tyr 
            260                 265                 270         


Arg Lys Glu Tyr Lys Tyr Thr Asp Lys Asp Asn Cys Ser Val Lys Glu 
        275                 280                 285             


Phe Glu Phe Val Ser Tyr Leu Asn Glu Phe Val Lys Asn Lys Phe Lys 
    290                 295                 300                 


Asn Val Asn Lys Asn Phe Ile Ser Asn Glu Lys Asn Asn Leu Tyr Ile 
305                 310                 315                 320 


Ile Leu Asn Ala Tyr Gly Glu Asp Ile Glu Asp Val Glu Val Val Lys 
                325                 330                 335     


Lys Tyr Ser Lys Glu Leu Tyr Lys Leu Ser Val Leu Lys Thr Asn Lys 
            340                 345                 350         


Asn Leu Gly Val Asn Val Lys Lys Leu Arg Glu Ser Ala Ile Glu Tyr 
        355                 360                 365             


Gly Tyr Cys Pro Leu Pro Tyr Asp Lys Glu Lys Glu Val Ala Lys Leu 
    370                 375                 380                 


Ser Ser Ile Lys His Lys Leu Tyr Lys Thr Tyr Asp Phe Val Ile Thr 
385                 390                 395                 400 


His Tyr Leu Asn Ser Asn Asp Lys Leu Leu Leu Glu Ile Val Glu Ala 
                405                 410                 415     


Leu Arg Leu Ser Lys Asn Asp Asp Glu Lys Glu Asn Val Tyr Lys Ile 
            420                 425                 430         


Tyr Ala Glu Lys Ile Phe Lys Ala Glu Tyr Val Ile Asn Pro Ile Lys 
        435                 440                 445             


Thr Ile Ser Asn Leu Phe Ala Glu Lys Gly Asp Lys Leu Phe Asn Glu 
    450                 455                 460                 


Lys Val Ser Ile Ser Glu Glu Tyr Val Glu Asp Ile Arg Ile Asp Lys 
465                 470                 475                 480 


Asn Ile His Asn Phe Thr Lys Val Ile Phe Phe Leu Thr Cys Phe Leu 
                485                 490                 495     


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Asn Ile Ile Ser Lys Leu 
            500                 505                 510         


Gln Val Ile Glu Asp His Asn Asn Val Ile Lys Ala Ile Ala Asn Asn 
        515                 520                 525             


Asn Asp Ala Val Tyr Lys Asp Tyr Ser Asp Lys Tyr Ala Val Phe Lys 
    530                 535                 540                 


Asn Ser Gly Lys Ile Ala Thr Lys Leu Glu Ala Ile Lys Ser Ile Ala 
545                 550                 555                 560 


Arg Met Glu Asn Lys Ile Asn Lys Ala Phe Lys Glu Pro Leu Leu Lys 
                565                 570                 575     


Asp Ala Met Leu Ala Leu Gly Val Ser Pro Asn Asp Leu Asp Glu Lys 
            580                 585                 590         


Tyr Glu Lys Tyr Phe Lys Thr Asp Val Asp Ala Asp Lys Asp His Gln 
        595                 600                 605             


Lys Val Ser Thr Phe Leu Met Asn Asn Val Ile Asn Asn Ser Arg Phe 
    610                 615                 620                 


Lys Tyr Val Val Lys Tyr Ile Asn Pro Ala Asp Ile Asn Arg Leu Ala 
625                 630                 635                 640 


Lys Asn Lys His Leu Val Lys Phe Val Leu Asp Gln Ile Pro His Lys 
                645                 650                 655     


Gln Ile Asp Ser Tyr Tyr Asn Ser Val Cys Thr Val Glu Glu Pro Ser 
            660                 665                 670         


Tyr Lys Gly Lys Ile Gln Leu Leu Thr Lys Lys Ile Thr Gly Leu Asn 
        675                 680                 685             


Phe Tyr Ser Leu Phe Glu Asn Cys Lys Ile Pro Asn Val Glu Lys Glu 
    690                 695                 700                 


Lys Lys Lys Ala Val Ile Thr Leu Tyr Phe Thr Ile Ile Tyr Ile Leu 
705                 710                 715                 720 


Val Lys Asn Leu Val Asn Ile Asn Gly Leu Tyr Thr Leu Ala Leu Tyr 
                725                 730                 735     


Phe Val Glu Arg Asp Gly Phe Phe Tyr Lys Lys Ile Cys Glu Lys Lys 
            740                 745                 750         


Asp Lys Lys Lys Thr Asn Lys Asp Val Asp Tyr Leu Leu Leu Pro Glu 
        755                 760                 765             


Ile Phe Ser Gly Ser Lys Tyr Arg Glu Glu Thr Lys Asn Leu Lys Leu 
    770                 775                 780                 


Pro Lys Glu Lys Asp Arg Glu Ile Met Lys Lys Tyr Leu Pro Asn Asp 
785                 790                 795                 800 


Glu Asp Arg Lys Glu Tyr Asn Lys Phe Phe Lys Gln Tyr Arg Asn Asn 
                805                 810                 815     


Ile Val His Leu Asn Ile Ile Ala Asn Leu Ser Lys Leu Thr Ser Thr 
            820                 825                 830         


Ile Asp Lys Glu Ile Asn Ser Tyr Phe Glu Ile Phe His Tyr Cys Ala 
        835                 840                 845             


Gln Arg Val Met Phe Asp Tyr Cys Lys Asn Asn Asn Lys Val Val Leu 
    850                 855                 860                 


Ala Lys Met Lys Asp Leu Ala His Ile Lys Ser Asp Cys Asp Glu Phe 
865                 870                 875                 880 


Ser Ser Lys Tyr Thr Tyr Pro Tyr Ser Ser Ala Val Leu Arg Phe Met 
                885                 890                 895     


Asn Leu Pro Phe Ala Tyr Asn Val Pro Arg Phe Lys Asn Leu Ser Tyr 
            900                 905                 910         


Gln Lys Phe Phe Asp Lys Gln Arg Leu Glu Ala Leu Glu Lys Asn Leu 
        915                 920                 925             


Asn Ile 
    930 


<210>  3056
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3056

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Ile Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Pro Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn His Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3057
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3057

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Phe 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Ala Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Val Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Lys Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3058
<211>  923
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3058

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Val Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Gln Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Glu Gly Asn Ser Asn Ile Glu Leu Gly Asp Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Asp Glu Ser His Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe Thr Asp 
    210                 215                 220                 


Pro Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Asp Asp Tyr 
            340                 345                 350         


Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys 
        355                 360                 365             


Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met 
    370                 375                 380                 


Leu Glu Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val 
385                 390                 395                 400 


Arg Ser Lys Met Tyr Lys Ile Met Asp Phe Leu Leu Phe Cys Asn Tyr 
                405                 410                 415     


Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg 
            420                 425                 430         


Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala 
        435                 440                 445             


Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp 
    450                 455                 460                 


His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp 
465                 470                 475                 480 


Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu 
                485                 490                 495     


Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly 
            500                 505                 510         


Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn 
        515                 520                 525             


Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu 
    530                 535                 540                 


Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile 
545                 550                 555                 560 


Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro 
                565                 570                 575     


Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu 
            580                 585                 590         


Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys 
        595                 600                 605             


Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr 
    610                 615                 620                 


Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala 
625                 630                 635                 640 


Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met 
                645                 650                 655     


Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys 
            660                 665                 670         


Ser Cys Val Glu Val Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg 
        675                 680                 685             


Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe Lys 
    690                 695                 700                 


Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg 
705                 710                 715                 720 


Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val 
                725                 730                 735     


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys 
            740                 745                 750         


Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala 
        755                 760                 765             


Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys 
    770                 775                 780                 


Glu Leu Cys Asp Asp Arg Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys 
785                 790                 795                 800 


Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp 
                805                 810                 815     


Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val 
            820                 825                 830         


Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser 
        835                 840                 845             


Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg 
    850                 855                 860                 


Glu Asn Tyr Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu 
865                 870                 875                 880 


Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser 
                885                 890                 895     


Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln 
            900                 905                 910         


Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920             


<210>  3059
<211>  975
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3059

Met Met Gly Lys His Leu Asn Ala Lys Gln Arg Glu Leu Glu Lys Lys 
1               5                   10                  15      


Leu Lys Asn Gln Gln Lys Gly Met Met Tyr Asn Lys Ser Thr Asp Ala 
            20                  25                  30          


Val Ser Val Pro Thr Leu Gln Ala Ala Pro Lys Lys Ala Ala Glu Ala 
        35                  40                  45              


Ser Thr Leu Ile Thr Pro Gly Thr Leu Lys Thr Lys Ala Lys Ala Met 
    50                  55                  60                  


Gly Leu Lys Ser Thr Leu Val Phe Asp Asp Lys Ile Val Val Thr Ser 
65                  70                  75                  80  


Phe Leu Asn Ser Lys Thr Glu Glu Asn Glu Lys Cys Ala His Ile Glu 
                85                  90                  95      


Lys Ile Thr Asp Cys Asn Gly Gln Thr Ile Val Glu Arg Pro Arg Met 
            100                 105                 110         


Phe Asn Thr Ser Ile Asn Ala Gln Gln Val Asp Leu Ser Lys Asp Asn 
        115                 120                 125             


Asp Glu Thr Asn Tyr Pro Asn Pro Ala Phe Glu Asp Cys Gly Arg Asp 
    130                 135                 140                 


Tyr Ile Asn Ile Lys Ser Ala Leu Glu Lys Arg Val Phe Gly Lys Thr 
145                 150                 155                 160 


Tyr Asn Lys Asp Asn Leu His Val Gln Ile Ala Tyr Asn Ile Phe Asp 
                165                 170                 175     


Ile Lys Lys Ile Ile Gly Thr Tyr Ile Asn Asn Ile Thr Tyr Ile Phe 
            180                 185                 190         


Tyr Asn Leu Gly Arg Glu Glu Tyr Asn Ala Lys Lys Asp Ile Ile Gly 
        195                 200                 205             


Asn Gln Asp Ser Asp Tyr Ile Asn Lys Leu Leu Asn Asn Thr Ser Ala 
    210                 215                 220                 


Tyr Phe Thr Tyr Phe Asp Gly Val Phe Lys Gln Ile Thr Asp Arg Asp 
225                 230                 235                 240 


Ser Asn Lys Asp Arg Glu Val Lys Asn Ser Tyr Asn Ala Leu Val Leu 
                245                 250                 255     


Lys Val Leu Tyr Tyr Leu Arg Gln Phe Cys Met His Gly Asn Thr Tyr 
            260                 265                 270         


Thr Lys Arg Asn Glu Glu Ser Phe Leu Ser Asp Thr Ala Leu Tyr Asn 
        275                 280                 285             


Val Lys Asp Phe Phe Ala Lys Ala Asp Pro Gln Ile Asn Glu Leu Ile 
    290                 295                 300                 


Asp Ala Val Tyr Ala Asp Gly Ile Lys Thr Ile Asn Asn Asp Phe Met 
305                 310                 315                 320 


Ala His Ala Lys Asn Asn Met Tyr Ile Ile Cys Glu Val Tyr Lys Asn 
                325                 330                 335     


Glu Val Glu Asp Ser Leu Met Lys Glu Tyr Tyr Asp Phe Val Val Arg 
            340                 345                 350         


Lys Glu Gly Asn Asn Leu Gly Phe Asn Thr Arg Gln Leu Arg Glu Ile 
        355                 360                 365             


Leu Ile Asp Lys Tyr Val Gly Asn Leu Arg Asp Lys Lys Tyr Asp Thr 
    370                 375                 380                 


Phe Arg Asn Lys Leu Tyr Thr Val Leu Gly Phe Ile Leu Val Lys Glu 
385                 390                 395                 400 


Ile Lys Arg Asn Pro Lys Ile Gln Asp Ser Phe Ile Ala Lys Leu Arg 
                405                 410                 415     


Ala Asn Gln Ser Gly Asp Glu Gly Lys Leu Lys Ile Tyr Asn Glu Phe 
            420                 425                 430         


Ala Pro Lys Ile Trp Ser Val Val Ser Ser Lys Phe Asn Ser Ala Ile 
        435                 440                 445             


Thr Cys Phe Asp Glu Glu Ser Leu Ser Lys Phe Lys Gly Tyr Lys Asp 
    450                 455                 460                 


Ile Asp Glu Ser Leu Ile Ser Arg Tyr Gly Ile Thr Val Ser Asn Thr 
465                 470                 475                 480 


Asp Thr Leu Val Lys Ile Leu Tyr Phe Leu Cys Lys Phe Leu Asp Gly 
                485                 490                 495     


Lys Glu Ile Asn Glu Leu Cys Cys Ala Met Ile Asn Lys Phe Asp Asn 
            500                 505                 510         


Ile Asn Asp Leu Ile Lys Thr Ala Ala Gln Cys Gly Glu Asp Ile Glu 
        515                 520                 525             


Phe Val Lys Glu Tyr Lys Leu Phe Ile Asn Ser Lys Asp Ile Ser Asp 
    530                 535                 540                 


Gln Ile Arg Val Val Lys Ser Ile Ser Lys Met Lys Pro Glu Leu Ser 
545                 550                 555                 560 


Asn Ile Gly Glu Val Leu Leu Leu Asp Ala Ile Asp Ile Leu Gly Tyr 
                565                 570                 575     


Lys Ile Asn Lys Tyr Lys Cys Asp Ala Asp Gly Asn Arg Leu Val Asp 
            580                 585                 590         


Ser Asn Asn Lys Pro Val Tyr Ser Glu Glu Tyr Cys Thr Phe Lys Lys 
        595                 600                 605             


Asp Phe Phe Glu Thr Cys Glu Leu Asp Glu Phe Gly Arg Val Lys Tyr 
    610                 615                 620                 


Asp Lys Lys Gly Lys Pro Val Ile Asn His Arg Arg Arg Asn Phe Ile 
625                 630                 635                 640 


Ile Asn Asn Val Leu Ser Ser Lys Trp Phe Phe Tyr Val Ala Lys Tyr 
                645                 650                 655     


Asn Arg Pro Ser Glu Cys Gln Lys Phe Met Lys Ser Lys Lys Leu Ile 
            660                 665                 670         


Ala Leu Ala Leu Lys Asp Val Pro Glu Thr Gln Ile Ala Arg Tyr Tyr 
        675                 680                 685             


His Ser Val Thr Gly Gly Arg Glu Gln Thr Asp Ser Glu Ala Met Arg 
    690                 695                 700                 


Thr Thr Leu Ile Ser Arg Leu His Glu Phe Ser Ile Lys Asp Val Leu 
705                 710                 715                 720 


Ser Ser Val Gly Ser Met Thr Ala Ser Glu Asn Lys Arg Gln Ile Glu 
                725                 730                 735     


Asn Ser Arg Lys Glu Gln Met Lys Ala Ile Val Lys Leu Tyr Leu Thr 
            740                 745                 750         


Val Val Tyr Leu Ile Ala Lys Ser Leu Val Lys Val Asn Thr Arg Phe 
        755                 760                 765             


Ser Ile Ala Phe Ser Ala Tyr Glu Arg Asp Val Ser Leu Leu Ala Asp 
    770                 775                 780                 


Glu Asn Glu Ser Ile Ala Leu Ala Asp Asn Asp Asp Asp Lys Trp Lys 
785                 790                 795                 800 


Thr Gly Asn Tyr Ile Phe Ala Leu Thr Lys His Phe Leu Asp Asn Asp 
                805                 810                 815     


Glu Pro Tyr Phe Asp Lys Tyr Asn Asn Ala Leu Gln Gln Ile Lys Gly 
            820                 825                 830         


Ile Thr Asp Pro Asn Glu Arg Arg Leu Ala Tyr Arg Ala Asn Asp Lys 
        835                 840                 845             


Val Ile Lys His Thr His Phe Asn Leu His Thr Asn Lys Tyr Val Lys 
    850                 855                 860                 


Asp Asn Tyr Glu Lys Ile Ser Lys Met Asn Lys Ile Val Thr Glu Tyr 
865                 870                 875                 880 


Arg Asn Asn Val Gln His Leu Ala Val Val Asn Asn Ile Thr Lys Tyr 
                885                 890                 895     


Leu Gly Asp Ile Ser Glu Val Thr Ser Tyr Tyr Ser Leu Tyr Cys Tyr 
            900                 905                 910         


Ile Leu Gln Arg Leu Leu Leu Asp Asn Asn Asn Asn Asp Lys Phe Ala 
        915                 920                 925             


Glu Ile Lys Glu Lys Leu Ile Lys Phe Gly Thr Tyr Asn Lys Asp Phe 
    930                 935                 940                 


Met Trp Leu Ile Asn Val Pro Phe Ala Tyr Asn Leu Pro Arg Tyr Lys 
945                 950                 955                 960 


Asn Leu Ser Asn Glu Glu Ile Phe Tyr Asp Val Ile Gln Asn Lys 
                965                 970                 975 


<210>  3060
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3060

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Glu Ser Ser Ser Asn Ile Lys Leu Cys Gly 
            100                 105                 110         


Val Thr Lys Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Gln Asn Thr Tyr Tyr Ile 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val 
            260                 265                 270         


Ser Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu 
    290                 295                 300                 


Tyr Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Val Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Glu Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Met Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Val Pro Asp Met Asn Ser Ser Leu Glu Ala 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asp Asp Lys Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  3061
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3061

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Val Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Met Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Glu Ser Ser Ser Asn Ile Lys Leu Cys Gly 
            100                 105                 110         


Val Thr Lys Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser 
        195                 200                 205             


His Asp Asp Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val 
    210                 215                 220                 


Phe Ile Asp Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn 
225                 230                 235                 240 


Val Arg Lys Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Asn Arg Val 
            260                 265                 270         


Ser Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asn Asn Ile Tyr Pro Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Gly 
        435                 440                 445             


Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Val Pro Asp Met Asn Ser Ser Leu Glu Ala 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Asp Arg Asp Lys Ser Pro Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  3062
<211>  928
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3062

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asp Tyr Asn 
                85                  90                  95      


Gln Thr Gln Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val 
    210                 215                 220                 


Phe Thr Asp Pro Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Cys Val Phe His Asp Leu Ser Glu His Ser Glu Tyr 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Asn Ser Lys Lys Val Tyr Arg Glu Cys 
305                 310                 315                 320 


Arg Glu Thr Leu Asn Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn 
                325                 330                 335     


Lys Gly Phe Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp 
            340                 345                 350         


Met Met Lys Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp 
        355                 360                 365             


Phe Ile Val Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys 
385                 390                 395                 400 


Gln Tyr Asp Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu 
                405                 410                 415     


Leu Phe Cys Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu 
            420                 425                 430         


Val Arg Lys Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile 
        435                 440                 445             


Tyr Ala Asp Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe 
    450                 455                 460                 


Glu Asn Ile Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly 
465                 470                 475                 480 


Lys Ala Asp Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys 
                485                 490                 495     


Asn Ala Ser Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr 
            500                 505                 510         


Tyr Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile 
        515                 520                 525             


Ser Lys Phe Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser 
    530                 535                 540                 


Ala Val Asp Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn 
545                 550                 555                 560 


Asp Ser Gln Arg Ile Thr Asn Glu Leu Phe Val Val Lys Asn Ile Ala 
                565                 570                 575     


Ser Met Arg Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp 
            580                 585                 590         


Ala Leu Thr Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile 
        595                 600                 605             


Ser Glu Ile Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu 
    610                 615                 620                 


Arg Asn Phe Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr 
625                 630                 635                 640 


Leu Ile Lys Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn 
                645                 650                 655     


Glu Lys Val Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile 
            660                 665                 670         


Glu Arg Tyr Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser 
        675                 680                 685             


Leu Glu Ala Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser 
    690                 695                 700                 


Phe Asp Asp Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn 
705                 710                 715                 720 


Val Ala Lys Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val 
                725                 730                 735     


Met Tyr Leu Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val 
            740                 745                 750         


Ile Ala Ile His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile 
        755                 760                 765             


Ile Pro Glu Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu 
    770                 775                 780                 


Ser Gln Thr Leu Cys Glu Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn 
785                 790                 795                 800 


Leu Phe Leu Lys Lys Asn Glu Arg Leu Arg Lys Cys Val Glu Val Asp 
                805                 810                 815     


Ile Asn Asn Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile 
            820                 825                 830         


Ala His Leu Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile 
        835                 840                 845             


Arg Thr Val Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg 
    850                 855                 860                 


Cys Ile Thr Lys Arg Glu Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys 
865                 870                 875                 880 


Tyr Glu Asp Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val 
                885                 890                 895     


Lys Ala Leu Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn 
            900                 905                 910         


Leu Ser Ile Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925             


<210>  3063
<211>  946
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3063

Met Lys Lys Phe Ser Asn Ile Lys Arg Leu Gly Val Lys Ser Val His 
1               5                   10                  15      


Tyr Ala Asn Asn Thr Val Ile Val Glu Asp His Phe Ser Lys Asn Thr 
            20                  25                  30          


Asn Ile Leu Phe Thr Ala Glu Tyr Glu Asn Ile Asp Asp Leu Lys Ser 
        35                  40                  45              


Cys Thr Asn Ile Asp Lys Thr Ala Glu Asn Lys Gly Val Arg Phe Thr 
    50                  55                  60                  


Asp Leu Lys Asn Lys Asn Gly Phe Glu Leu Ser Ala Met Ala Gln Lys 
65                  70                  75                  80  


Gln Ile Leu Lys Ser Arg Val Asn Arg Val Lys Lys Val Ser Tyr Thr 
                85                  90                  95      


Gln Glu Leu Phe Asp Ile Thr Thr Asp Asn Asn Ile Glu Val Gln Ile 
            100                 105                 110         


Phe Ser Asn Leu Glu Asp Val Lys Lys Val Ile Ala Pro Tyr Tyr Asn 
        115                 120                 125             


Asn Val Ala Tyr Ala Ile Asn Ser Leu Tyr Arg Asp Ile Ser Asn Asp 
    130                 135                 140                 


Asp Ser Tyr Gly Phe Asp Lys Ile Gly Ser Ile Pro Val Asp Ala Asp 
145                 150                 155                 160 


Trp Tyr Asn Phe Leu Lys Asp Ala Pro Asp Lys Lys Glu Lys Trp Thr 
                165                 170                 175     


Thr Tyr Ile Ile Pro Ser Tyr Lys Lys Val Ile Ala Arg Phe Gly Ile 
            180                 185                 190         


Gln Met Glu Lys Asn Gln Gln Val Asn Phe Cys Lys Cys Leu Glu Tyr 
        195                 200                 205             


Val Ala Ile Arg Asn Gly Leu Phe Val Lys Phe Lys Asp Glu Lys Val 
    210                 215                 220                 


Asp Pro Asp Lys Leu Leu Asn Lys Lys Ile Gln Glu Lys Leu Asp Lys 
225                 230                 235                 240 


Leu Ile Ser Asp Lys Glu Val Asn Asp Lys Leu Phe Glu Leu Ala Lys 
                245                 250                 255     


Thr Pro Val Ser Glu Phe Cys Ala Glu Ala Asn Ala Ile Pro Leu Tyr 
            260                 265                 270         


Arg Tyr Ala Phe Ile Gly Gln Lys Gly Lys Arg Ile Glu Lys Ile Val 
        275                 280                 285             


Leu Asp Lys Leu Glu Glu Asn Glu Ile Leu Ser Ser Leu Val Arg Lys 
    290                 295                 300                 


Ile Asp Glu Asn Glu Thr Thr Tyr Asn Tyr Leu Arg Leu Leu Ser Ala 
305                 310                 315                 320 


Ile Arg Gln Tyr Val Val His Asn Ser Arg Lys Val Arg Ile Asp Lys 
                325                 330                 335     


Asn Val Phe Ile Asn Asp Thr Ala Lys Arg Asp Val Glu Glu Phe Ala 
            340                 345                 350         


Lys Gln Phe Gln Lys Asn Asn Tyr Lys Tyr Phe Cys Ile Leu Lys Glu 
        355                 360                 365             


Leu Tyr Ser Asp Ser Asp Ile Leu Glu Gln Phe Phe Asp Tyr Thr Val 
    370                 375                 380                 


Phe Asp Glu Ala Arg Asn Leu Lys Ile Ser Ile Asp Lys Ile Lys Lys 
385                 390                 395                 400 


Gly Ile Thr Ala Asn Ile Asp Ile Ser Ala Asp Val Glu Pro Asp Lys 
                405                 410                 415     


Leu Ser Glu Tyr Ala Asn Lys Phe Arg Thr Val Thr Met Phe Ala Leu 
            420                 425                 430         


Thr Lys Tyr Leu Lys Glu Asn Val Gly Glu Ile Glu Asp Phe Leu Ala 
        435                 440                 445             


Asn Ile Lys Val Cys Ser Ser Asp Glu Glu Lys Ala Gly Val Tyr Glu 
    450                 455                 460                 


Gln Lys Ala Lys Glu Phe Ile Thr Lys Phe Asp Ser Phe Lys Asp Ile 
465                 470                 475                 480 


Arg Ser Val Val Lys Lys His Leu Gly Thr Gln Lys Val Asn Glu Lys 
                485                 490                 495     


Phe Asp Phe Tyr Pro Ser Asp Ile Asn Phe Gly Arg Asp Ser Asn Val 
            500                 505                 510         


Phe Phe Asn Met Leu Tyr Val Met Ser Lys Phe Leu Thr Val Asn Glu 
        515                 520                 525             


Ala Arg Ile Met Phe Gln Lys Ile Lys Ser Lys Tyr Asp Ser Val Lys 
    530                 535                 540                 


Ser Leu Leu Lys Ile Ala Glu Leu Thr Gly Val Thr Leu Ser Asp Asn 
545                 550                 555                 560 


Leu Phe Asp Arg Phe Arg Met Ile Phe Asp Lys Glu Arg Val Asp Glu 
                565                 570                 575     


Tyr Gln Lys Gln Leu Ile Val Leu Gln Ser Ile Arg Thr Arg Asn Gly 
            580                 585                 590         


Val Ser Gln Glu Gly Phe Ala Lys Glu Leu Lys Arg Ile Phe Asp Met 
        595                 600                 605             


Phe Lys Lys Asp Asp Ile Ser Tyr Glu Glu Phe Glu Lys Glu Leu Ser 
    610                 615                 620                 


Leu Asp Glu Asn Gln Asn Glu Ile Lys Asn Lys Ser Phe Lys Leu Lys 
625                 630                 635                 640 


Pro Leu Lys Ser Tyr Leu Arg Asn Asp Val Tyr Lys Ser Lys Gln Tyr 
                645                 650                 655     


Gln Tyr Ile Ser Ser Phe Ala Ser Ala Gly Ile Cys Gln Lys Ile Met 
            660                 665                 670         


Glu Asn Lys Asp Ile Val Ala Phe Val Leu Asn Gly Met Leu Tyr Gln 
        675                 680                 685             


Glu Gly Lys Leu Ser Met Pro Met His Lys Tyr Val Ala Lys Val Tyr 
    690                 695                 700                 


His Asp Phe Arg Arg Glu Lys Ile Asp Glu Asn Ser Ala Asn Tyr Leu 
705                 710                 715                 720 


Leu Asp Gln Asn Gln Ile Ser Ser Leu Val Asn Ser Leu Cys Asp Leu 
                725                 730                 735     


Lys Leu Glu Asn Ile Ile Glu Ala Ile Phe Lys Glu Ser Arg Val Asn 
            740                 745                 750         


Tyr Lys Ala Leu Val Arg Leu Tyr Leu Asn Ile Cys Tyr Leu Phe Val 
        755                 760                 765             


Lys Asn Ile Ile Ser Leu Asn Ser Thr Tyr Leu Ile Gln Phe Gln Asp 
    770                 775                 780                 


Tyr Glu Asn Ile Tyr Lys Gln Leu His Leu Glu Asp Leu Met Asp Ile 
785                 790                 795                 800 


Thr Tyr Asp Phe Gly Val Leu Asn Asn Phe Val Glu Asn Ala Pro Asn 
                805                 810                 815     


Lys Lys Cys Arg Ser Tyr Met Gln Leu Gln Thr Leu Leu Glu Lys Asp 
            820                 825                 830         


Tyr Ile Lys Asp Tyr Ile Tyr Thr Pro Glu Tyr Gln Val Leu Gln Asp 
        835                 840                 845             


Arg Tyr Arg Asn Leu Val Val His Ser Ser Leu Leu Phe Gly Leu Asp 
    850                 855                 860                 


Lys Ile Asp Phe Asp Phe Gly Glu Val Gln Asn Ile Ser Ser Tyr Phe 
865                 870                 875                 880 


Ala Ile Tyr Gln Thr Leu Val Gln Arg Leu Val Glu Gln Asp Ala Arg 
                885                 890                 895     


Glu Val Trp Gly Glu Lys Phe Asp Glu Tyr Phe Ala Leu Asn Asn Gly 
            900                 905                 910         


Lys Thr Tyr Ser Thr Lys Leu Cys Ile Ala Leu Asn Met Pro Tyr Ala 
        915                 920                 925             


Tyr Asn Ile Ser Arg Phe Asn Asn Asn Thr Ile Glu Lys Tyr Ser Asn 
    930                 935                 940                 


Lys Arg 
945     


<210>  3064
<211>  1141
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3064

Met Gly Val Glu Lys Asn Lys Val Phe Glu Ser Val Ile Met Asn Phe 
1               5                   10                  15      


Asp Gln Glu Arg Lys Tyr Gly Phe Ile Glu Tyr Lys Glu Thr Asn Asn 
            20                  25                  30          


Leu Phe Phe His Met Glu Asn Val Lys Asn Pro Lys Glu Ile Val Lys 
        35                  40                  45              


Gly Ala Lys Val Arg Phe Glu Ile Tyr Glu Asn Pro Lys Pro Lys Lys 
    50                  55                  60                  


Gln Asn Gln Arg Phe Ser Ala Ile Asn Val Glu Val Ile Thr Asp Glu 
65                  70                  75                  80  


Thr His Lys Glu Ala Lys Ile Gln Lys Asn Glu Phe Lys Thr Phe Asp 
                85                  90                  95      


Gln Phe Thr Lys Glu Leu Gln Glu Thr Gln Lys Val Asn Gly Glu Thr 
            100                 105                 110         


Lys Lys Glu His Ile Thr Lys Asn Lys His Thr Asn Val Lys Ala Ala 
        115                 120                 125             


Gly Val Lys Ser Val Phe Ala Val Asp Asp Gly Asn Val Leu Ile Thr 
    130                 135                 140                 


Ser Phe Gly Arg Gly Asn Ala Ala Asp Ile Glu Thr Leu Lys Ser Asp 
145                 150                 155                 160 


Asp Asp Lys Thr Ile Asn Leu Thr Glu Thr Glu Asn Gln Lys Lys Tyr 
                165                 170                 175     


Val Val Thr Asn Lys Arg Ser Asn Val Lys Gly Leu Ala Asp Asn Pro 
            180                 185                 190         


Thr Lys Val Glu Ser Ile Ile Pro Gly Glu Thr Gln Ile Gly Phe Lys 
        195                 200                 205             


Ser Ile Leu Glu Lys His Phe Phe Gly Arg Thr Phe Asn Asp Asn Ile 
    210                 215                 220                 


His Ile Gln Ile Ile His Asn Ile Leu Asp Ile Lys Lys Ile Leu Ala 
225                 230                 235                 240 


Val His Thr Asn Asn Ile Val Tyr Ala Leu Asp Asn Ile His Glu Arg 
                245                 250                 255     


Gly Arg Glu Asn Ser Ala Glu Lys Pro Ile Asp Met Ile Gly Ala Gly 
            260                 265                 270         


Gly Ile Ser Thr Ser Lys Glu Tyr Glu Gln Tyr Cys Ser Glu Lys Ser 
        275                 280                 285             


Asp Tyr Glu Asp Asn Phe Leu Lys Gln Leu Ile Asn Asn Glu Arg Ile 
    290                 295                 300                 


Ala Tyr Phe Gly Asn Ala Phe Phe Lys Asp Glu Gly Asn Lys Lys Val 
305                 310                 315                 320 


Met Arg Thr Glu Lys Glu Ile Tyr Tyr Ile Leu Gly Met Leu Asn Glu 
                325                 330                 335     


Val Arg Asn Val Ser Thr His Phe Thr Glu Glu Asp Asn Arg Asp Trp 
            340                 345                 350         


Ala Lys Ala Asn Leu Tyr Asn Leu Ser Asn Arg Leu Lys Val Gly Ser 
        355                 360                 365             


Lys Glu Val Leu Asn Gln Leu Tyr Lys Glu Lys Ile Asp Lys Ile Asp 
    370                 375                 380                 


Ala Asn Gly Phe Val Asn Lys Gly Cys Lys Arg Asp Phe Ser Ile Leu 
385                 390                 395                 400 


Phe Lys Ser Leu Asn Leu Thr Thr Asp Lys Asp Lys Gly Glu Leu Val 
                405                 410                 415     


Val Gly Phe Tyr Asp Phe Ser Ile Arg Lys Asn Tyr Lys Asn Ile Gly 
            420                 425                 430         


Phe Ser Ile Lys Thr Leu Arg Glu Tyr Met Leu Lys Ile Ser Asn Ser 
        435                 440                 445             


Thr Leu Cys Ala Asp Thr Ile Ser Asn Asn Ala Ile Arg Pro Lys Ala 
    450                 455                 460                 


Tyr Lys Leu Tyr Asp Phe Ile Ile Trp His Tyr Tyr Met Asn Lys Pro 
465                 470                 475                 480 


Asp Lys Ile Asn Asp Phe Val Glu Lys Leu Arg Thr Gln Asn Lys Asn 
                485                 490                 495     


Asp Glu Lys Ile Lys Leu Tyr Tyr Asp Glu Ala Val Cys Leu Leu Ser 
            500                 505                 510         


Glu Leu Gly Arg Glu Ile His Thr Met Thr Ser Cys Val His Asn Ile 
        515                 520                 525             


Glu Asn Thr Ser Tyr Glu Ile Thr Asp Lys Lys Gln Lys Glu Tyr Tyr 
    530                 535                 540                 


Lys Met Gln Ile Asn Ser Leu Asn Ser Ala Asp Lys Val Ser Asp Phe 
545                 550                 555                 560 


Ser Lys Val Ile Tyr Leu Val Thr Leu Phe Leu Asp Gly Lys Glu Ile 
                565                 570                 575     


Asn Asp Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp Asn Ile Ala Ser 
            580                 585                 590         


Leu Leu Ser Val Leu Glu Lys Gln Ser Gly Lys Lys Val Glu Phe Val 
        595                 600                 605             


Glu Asn Tyr Ser Phe Phe Asn Ser Ser Asn Leu Leu Lys Glu Lys Thr 
    610                 615                 620                 


Leu Asn Lys Ser Glu Asn Tyr Thr Cys Lys Ile Val Glu Glu Leu Arg 
625                 630                 635                 640 


Glu Ile Asn Ser Phe Ala Arg Met Thr Gly Asp Cys Lys Ile Arg Lys 
                645                 650                 655     


Ser Ala Phe Glu Asp Ala Ser Gln Leu Leu Gly Tyr His Asp Lys Thr 
            660                 665                 670         


Val Asn Asn Leu Phe Glu Val Leu Arg Leu Lys Glu Leu Glu Ser Lys 
        675                 680                 685             


Asp Trp Lys Lys Arg Thr Asp Asp Glu Gln Gln Glu Tyr Asp Arg Leu 
    690                 695                 700                 


Leu Asn Lys His His Tyr Phe Lys Ser Gly Lys Lys Leu Pro Asp Thr 
705                 710                 715                 720 


Gly Leu Arg Asn Phe Ile Ile Asn Asn Val Ile Glu Ser Arg Arg Phe 
                725                 730                 735     


Asn Tyr Ile Val Arg Tyr Ala Asp Pro Lys Lys Ile Arg Lys Cys Thr 
            740                 745                 750         


Glu Asn Asn Glu Leu Leu Lys Phe Ala Phe Lys Asp Val Pro Asp Ser 
        755                 760                 765             


Gln Val Asp Arg Tyr Tyr Asn Ile Cys Val Thr Asn Lys Ile Thr Asn 
    770                 775                 780                 


Ala Thr Arg Glu Glu Lys Ile Glu Arg Leu Val Asp Ile Ile Lys Ser 
785                 790                 795                 800 


Met Asn Leu Ser Lys Val Ala Thr Val Lys Gln Arg Asp Lys Gln Asp 
                805                 810                 815     


Asn Val Glu Lys Gln Lys Gln Leu Ala Ile Met Ser Leu Tyr Leu Asn 
            820                 825                 830         


Ile Leu Tyr Gln Ile Ala Lys Asn Leu Val Tyr Val Asn Ser Arg Tyr 
        835                 840                 845             


Val Met Ala Phe His Ser Leu Glu Arg Asp Ser Gln Met Leu Phe Asp 
    850                 855                 860                 


Ala Tyr Tyr Asp Val Lys Arg Gly Tyr Cys Asp Leu Ser Thr Val Leu 
865                 870                 875                 880 


Leu Phe Gly Val Asp Asp Leu Gln Asn Arg Asn Arg Gly Ser Tyr Lys 
                885                 890                 895     


Tyr Leu Arg Asp Asn Arg Arg Ser Asn Lys Asp Val Ile Glu Thr Phe 
            900                 905                 910         


Gly Asp Phe Lys Gly Lys Val Ser Lys Val Val Glu Lys Lys Asn Gln 
        915                 920                 925             


Gly Leu Thr Asn Glu Ile Tyr Asp Ser Leu Cys Asn Val Ala Gly Thr 
    930                 935                 940                 


Thr Lys Thr Glu Val Gln Asn Glu Ile Lys Ser Ile Leu Lys Ser Asn 
945                 950                 955                 960 


Gly Leu Asp Glu Ser Ala Ser Ser Tyr Leu Ser His Lys Leu Val Asn 
                965                 970                 975     


Lys Val His Ser Tyr Lys Tyr Leu Lys Gln Asn Leu Asp Cys Ala Asp 
            980                 985                 990         


Asn Thr Met Ile Asn Gln Phe Arg  Asn Asn Val Ala His  Leu Asn Thr 
        995                 1000                 1005             


Ile Arg  Asn Met Asp Gly Ile  Glu Asn Val Thr Gly  Ile Thr Ser 
    1010                 1015                 1020             


Tyr Phe  Gln Ile Tyr His Tyr  Leu Met Gln Lys Ala  Leu Tyr Lys 
    1025                 1030                 1035             


Glu Phe  Lys Lys Cys Arg Glu  Asn Ala Val Arg Lys  Trp Ile Pro 
    1040                 1045                 1050             


Tyr Ile  Thr Glu Asn Ala Glu  Pro Lys Tyr Val Tyr  Trp Asn Lys 
    1055                 1060                 1065             


Lys Glu  Gln Gln Glu Val Glu  Val Ser Phe Asn Pro  Lys Ile Phe 
    1070                 1075                 1080             


Gly Tyr  Met Glu Asn Ile Lys  Asn His Ser Asn Thr  Tyr Cys Lys 
    1085                 1090                 1095             


Asp Phe  Val Lys Ala Leu Cys  Ala Pro Phe Ala Tyr  Asn Leu Pro 
    1100                 1105                 1110             


Arg Phe  Lys Asn Leu Ser Ile  Glu Glu Leu Phe Asp  Met His Glu 
    1115                 1120                 1125             


Leu Ser  Glu Glu Pro Lys Glu  Ser Met Lys Leu Thr  Asp 
    1130                 1135                 1140     


<210>  3065
<211>  926
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3065

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Gln Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Cys Val Phe His Asp Leu Ser Glu His Ser Glu Tyr 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Asn Ser Lys Lys Val Tyr Arg Glu Cys 
305                 310                 315                 320 


Arg Glu Thr Leu Asn Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn 
                325                 330                 335     


Lys Gly Phe Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp 
            340                 345                 350         


Met Met Lys Asp Asp Tyr Glu Ala Asp Asp Ile Ile His Leu Tyr Tyr 
        355                 360                 365             


Asp Phe Ile Val Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys 
    370                 375                 380                 


Lys Leu Arg Glu Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp 
385                 390                 395                 400 


Lys Gln Tyr Asp Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe 
                405                 410                 415     


Leu Leu Phe Cys Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala 
            420                 425                 430         


Leu Val Arg Lys Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly 
        435                 440                 445             


Ile Tyr Ala Asp Glu Ala Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp 
    450                 455                 460                 


Phe Glu Asn Ile Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu 
465                 470                 475                 480 


Gly Lys Ala Asp Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys 
                485                 490                 495     


Lys Asn Ala Ser Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu 
            500                 505                 510         


Thr Tyr Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu 
        515                 520                 525             


Ile Ser Lys Phe Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser 
    530                 535                 540                 


Ser Ala Val Asp Val Glu Cys Glu Leu Thr Ala Gly Tyr Arg Leu Phe 
545                 550                 555                 560 


Asn Asp Ser Gln Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile 
                565                 570                 575     


Ala Ser Met Arg Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg 
            580                 585                 590         


Asp Ala Leu Thr Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg 
        595                 600                 605             


Ile Ser Glu Ile Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly 
    610                 615                 620                 


Leu Arg Asn Phe Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val 
625                 630                 635                 640 


Tyr Leu Ile Lys Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys 
                645                 650                 655     


Asn Glu Lys Val Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln 
            660                 665                 670         


Ile Glu Arg Tyr Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser 
        675                 680                 685             


Ser Leu Glu Ala Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile 
    690                 695                 700                 


Ser Phe Asp Asp Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu 
705                 710                 715                 720 


Asn Val Ala Lys Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr 
                725                 730                 735     


Val Met Tyr Leu Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr 
            740                 745                 750         


Val Ile Ala Ile His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu 
        755                 760                 765             


Ile Ile Pro Glu Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile 
    770                 775                 780                 


Leu Ser Gln Thr Leu Cys Glu Leu Cys Asp Glu Ser Pro Asn Leu Phe 
785                 790                 795                 800 


Leu Lys Lys Asn Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn 
                805                 810                 815     


Asn Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His 
            820                 825                 830         


Leu Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr 
        835                 840                 845             


Val Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile 
    850                 855                 860                 


Thr Lys Arg Glu Asp Asp Lys Lys Gln Glu Glu Lys Ile Lys Phe Glu 
865                 870                 875                 880 


Asp Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala 
                885                 890                 895     


Leu Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser 
            900                 905                 910         


Ile Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925     


<210>  3066
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3066

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Gln Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ser Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala 
        675                 680                 685             


Lys Cys Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asp Asp Lys Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  3067
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3067

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Thr 
            20                  25                  30          


Pro Thr Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Lys Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asn Ser Ser Asn Ile Glu Leu Arg Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Lys Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Glu Ala Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp Asp Thr 
    850                 855                 860                 


Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  3068
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3068

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asp Tyr Asn 
                85                  90                  95      


Gln Thr Gln Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val 
    210                 215                 220                 


Phe Thr Asp Pro Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Cys Val Phe His Asp Leu Ser Glu His Ser Glu Tyr 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Asn Ser Lys Lys Val Tyr Arg Glu Cys 
305                 310                 315                 320 


Arg Glu Thr Leu Asn Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn 
                325                 330                 335     


Lys Gly Phe Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp 
            340                 345                 350         


Met Met Lys Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp 
        355                 360                 365             


Phe Ile Val Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys 
385                 390                 395                 400 


Gln Tyr Asp Pro Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu 
                405                 410                 415     


Leu Phe Cys Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu 
            420                 425                 430         


Val Arg Lys Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile 
        435                 440                 445             


Tyr Ala Asp Glu Ala Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe 
    450                 455                 460                 


Glu Asn Ile Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly 
465                 470                 475                 480 


Lys Ala Asp Met Asp Phe Asp Glu Lys Ile Ile Asp Ser Glu Lys Lys 
                485                 490                 495     


Asn Ala Ser Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr 
            500                 505                 510         


Tyr Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile 
        515                 520                 525             


Ser Lys Phe Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser 
    530                 535                 540                 


Ala Val Asn Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn 
545                 550                 555                 560 


Asp Ser Gln Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala 
                565                 570                 575     


Ser Met Arg Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp 
            580                 585                 590         


Ala Leu Thr Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile 
        595                 600                 605             


Ser Glu Ile Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu 
    610                 615                 620                 


Arg Asn Phe Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr 
625                 630                 635                 640 


Leu Ile Lys Tyr Ala Asn Ala Gln Lys Ile Arg Lys Val Ala Glu Asn 
                645                 650                 655     


Glu Lys Val Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile 
            660                 665                 670         


Glu Arg Tyr Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser 
        675                 680                 685             


Leu Glu Ala Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser 
    690                 695                 700                 


Phe Asp Asp Phe Lys Lys Val Lys Gln Gln Ala Lys Gly Arg Glu Asn 
705                 710                 715                 720 


Val Ala Lys Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val 
                725                 730                 735     


Met Tyr Leu Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val 
            740                 745                 750         


Ile Ala Ile His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile 
        755                 760                 765             


Ile Pro Glu Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu 
    770                 775                 780                 


Ser Gln Lys Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Ile Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  3069
<211>  900
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3069

Leu Ser Thr Lys Lys Arg Phe Arg Tyr Ser Val Ala Ala Lys Ala Ala 
1               5                   10                  15      


Gly Leu Lys Ser Ser Leu Ala Val Asp Thr Asp Arg Thr Val Met Thr 
            20                  25                  30          


Ser Phe Gly His Gly Asn Ala Ala Ile Leu Glu Lys Glu Ile Val Asp 
        35                  40                  45              


Gly Glu Ile Ser Val Leu Asn Ile Glu Asn Pro Ala Phe Asp Ala Val 
    50                  55                  60                  


Ile Asn Asp Lys Lys Tyr Ala Leu Thr Gly His His Ala Gly Val His 
65                  70                  75                  80  


Ala Leu Val Asp Gln Pro Gln Asn Arg Ser Asp Ala Val His Ile Arg 
                85                  90                  95      


Gly Ala Leu Glu Lys Lys Tyr Phe Gly Asp Thr Phe Ala Asp Asn Ile 
            100                 105                 110         


His Val Gln Ile Ala Tyr Asn Ile Leu Asp Ile Thr Lys Ile Leu Thr 
        115                 120                 125             


Val Tyr Ala Asn Asn Val Val Tyr Ala Leu Asn Asn Leu Val His Ala 
    130                 135                 140                 


Asp Asp Asp Thr Gln Ala Asp Glu Leu Asp Ser Leu Gly Asn Phe Ser 
145                 150                 155                 160 


Ala Gly Thr Ser Tyr Ala Lys Ser Lys Ser Lys Ser Lys Ser Lys Gln 
                165                 170                 175     


Gln Asp Phe Val Glu Leu Phe Ile Lys Lys Lys Glu Ile His Gly Tyr 
            180                 185                 190         


Phe Gly Asp Thr Phe Ala Phe Leu Asp Lys Arg Ile Ala Asp Ala Asp 
        195                 200                 205             


Lys Glu Lys Gln Val Tyr Ala Met Leu Ala Cys Leu Gly Ser Leu Arg 
    210                 215                 220                 


Gln Ala Cys Ser His Tyr Arg Ile Arg Tyr Ser Val Asn Gly Lys Asn 
225                 230                 235                 240 


Val Asp Ala Asp Ala Asp Thr Trp Leu Phe Ser Ser Ala Gln Leu Asp 
                245                 250                 255     


Gln Thr Asp Pro Leu Phe Ser Glu Met Leu Asn Arg Ile Tyr Ser His 
            260                 265                 270         


Lys Ile Lys Thr Val Asn Gln Asn Phe Phe Glu Asn Asn Arg Lys Ala 
        275                 280                 285             


Asn Phe Pro Ile Leu Lys Lys Met Tyr Pro Glu Thr Thr Leu Lys Val 
    290                 295                 300                 


Leu Met Asn Glu Tyr Tyr Asp Phe Ser Ile Arg Lys Gly Tyr Lys Asn 
305                 310                 315                 320 


Phe Gly Phe Ser Ile Lys Ser Leu Arg Glu Ala Leu Leu Ser Pro Gln 
                325                 330                 335     


Tyr Glu Ser Leu Ile Gly Val Gln Ile Lys Asp Asn Lys Glu Tyr Asp 
            340                 345                 350         


Thr Val Arg Ser Lys Leu Tyr Gln Leu Phe Asp Phe Ala Leu Thr Arg 
        355                 360                 365             


Tyr Phe Asn Gln His Pro Asp Met Val Asp Ala Phe Val Val Glu Leu 
    370                 375                 380                 


Arg Ser Leu Ala Lys Asp Glu Asp Ala Lys Asn Ala Val Tyr Glu Lys 
385                 390                 395                 400 


Tyr Ala Lys Ala Val Trp Asn Asp Val Lys Gln Pro Ile Ala Val Met 
                405                 410                 415     


Leu Ser Tyr Met Asn Gly Ser Ala Ile Lys Asn Ile Lys Ala Phe Glu 
            420                 425                 430         


Leu Lys Pro Asp Gln Lys Glu Leu Asn Gly Ile Met Asn Ser Asn Ala 
        435                 440                 445             


Leu Asp Val Pro His Phe Cys Lys Leu Val Tyr Phe Leu Thr Arg Phe 
    450                 455                 460                 


Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Val Asn Lys 
465                 470                 475                 480 


Phe Asp Asn Ile His Ser Phe Asn Gln Val Leu Thr Ala Leu Gly Leu 
                485                 490                 495     


Ser Ala Ser Tyr Glu Ala Asp Tyr Lys Ile Phe Glu Asp Ser Gly Arg 
            500                 505                 510         


Val Val Glu Tyr Leu Arg Glu Ile Asn Ser Phe Ala Arg Met Thr Val 
        515                 520                 525             


Asp Met Glu Lys Ile Lys Arg Ser Ala Tyr Lys Lys Ala Leu Leu Ile 
    530                 535                 540                 


Leu Gly Ser Ser Lys Tyr Ser Asp Glu Asp Leu Asp Ala Arg Val Asp 
545                 550                 555                 560 


Glu Met Leu Gly Val Asp Tyr Asn Gln Asn Gly Glu Lys Ile Lys Val 
                565                 570                 575     


Arg Val Asp Thr Gly Phe Arg Asn Phe Ile Ala Asn Asn Val Val Glu 
            580                 585                 590         


Ser Ser Arg Phe His Tyr Leu Ile Arg Tyr Cys His Pro Arg Lys Ile 
        595                 600                 605             


Arg Asn Leu Ala Gly Asn Ala Ala Leu Ile Glu Tyr Gln Leu Arg Arg 
    610                 615                 620                 


Leu Pro Glu Leu Gln Ile Leu Arg Tyr Tyr Glu Ala Cys Thr Glu Pro 
625                 630                 635                 640 


Ile Lys Arg Thr Ala Arg Thr Met Asp Glu Lys Ile Gly Thr Leu Ile 
                645                 650                 655     


Asp Leu Ile Val Lys Met Asp Phe Ser Gln Phe Glu Asp Val Gln Gln 
            660                 665                 670         


Asn Asp Arg Val Arg Val Phe Ser Asp Ala Glu Lys Lys Glu Lys Ile 
        675                 680                 685             


Arg Lys Met Arg Glu Lys Gln Arg Tyr Gln Ser Ile Ile Ser Leu Tyr 
    690                 695                 700                 


Leu Thr Met Leu Tyr Leu Ile Val Lys Asn Leu Val Asn Ile Asn Ala 
705                 710                 715                 720 


Arg Tyr Val Met Ala Phe Gln Ala Trp Glu Arg Asp Asn Tyr Leu Leu 
                725                 730                 735     


Leu Gln Leu Ser Gly Lys Glu Ala Glu Ala Glu Tyr Leu Asn Leu Thr 
            740                 745                 750         


Arg His Phe Ile Glu Pro Leu Asp Gly Ala Lys Pro Tyr Leu Lys Lys 
        755                 760                 765             


Arg Pro Val Glu Tyr Leu Lys Lys Asp Met Ala Met Val Gly Asn Ser 
    770                 775                 780                 


Ser Ile Arg His Phe Arg Asn Ala Thr Val His Leu Asn Val Ile Met 
785                 790                 795                 800 


Glu Ala His Arg Tyr Thr Lys Asp Ile Lys Tyr Ile Gly Ser Tyr Tyr 
                805                 810                 815     


Ala Leu Tyr His Tyr Ile Leu Gln Arg His Leu Leu Asp Lys Ile Glu 
            820                 825                 830         


Glu Asp Ser Tyr Ala Glu Lys Thr Val Ser Glu Lys Leu Trp Glu Ser 
        835                 840                 845             


Gln Ile Ser Gln Tyr Gly Thr Tyr Ser Lys Asp Phe Val Lys Ala Leu 
    850                 855                 860                 


Cys Cys Pro Phe Gly Tyr Asn Leu Pro Arg Phe Lys Asn Leu Ser Ile 
865                 870                 875                 880 


Glu Gln Leu Phe Asp Arg Asn Glu Ser Lys Glu Ile Thr Asp Ala Thr 
                885                 890                 895     


Ala Pro Arg Gln 
            900 


<210>  3070
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3070

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Ile Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Pro Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn His Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Val Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3071
<211>  927
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3071

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Thr Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asp Tyr Asn 
                85                  90                  95      


Gln Thr Gln Leu Ser Ser Lys Asp Ser Ser Asn Ile Glu Leu His Gly 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Leu Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Ser Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Asp Ser Asn 
        195                 200                 205             


Tyr Asp Phe Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe 
    210                 215                 220                 


Thr Asn Pro Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Lys Asn Ile 
225                 230                 235                 240 


Arg Lys Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu 
                245                 250                 255     


Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Asn Ala Leu 
            260                 265                 270         


Glu Ala Tyr Lys Lys Arg Val Tyr Tyr Met Leu Ala Ile Val Gly Gln 
        275                 280                 285             


Ile Arg Gln Cys Val Phe His Asp Leu Thr Asp His Ser Glu Tyr Asp 
    290                 295                 300                 


Leu Tyr Ser Phe Ile Tyr Asn Ser Lys Lys Val Tyr Lys Glu Cys Arg 
305                 310                 315                 320 


Glu Thr Leu Asp Tyr Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys 
                325                 330                 335     


Gly Phe Ile Glu Gly Asn Lys Ile Asn Ile Ser Leu Leu Ile Asp Met 
            340                 345                 350         


Met Lys Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe 
        355                 360                 365             


Ile Val Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu 
    370                 375                 380                 


Arg Glu Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln 
385                 390                 395                 400 


Tyr Asp Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu 
                405                 410                 415     


Phe Cys Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val 
            420                 425                 430         


Arg Lys Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr 
        435                 440                 445             


Ala Asp Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu 
    450                 455                 460                 


Asn Ile Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys 
465                 470                 475                 480 


Ala Asp Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn 
                485                 490                 495     


Ala Ser Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr 
            500                 505                 510         


Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser 
        515                 520                 525             


Lys Phe Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala 
    530                 535                 540                 


Val Asp Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp 
545                 550                 555                 560 


Ser Gln Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser 
                565                 570                 575     


Met Arg Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala 
            580                 585                 590         


Leu Thr Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser 
        595                 600                 605             


Glu Ile Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg 
    610                 615                 620                 


Asn Phe Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu 
625                 630                 635                 640 


Ile Lys Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu 
                645                 650                 655     


Lys Val Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu 
            660                 665                 670         


Arg Tyr Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu 
        675                 680                 685             


Glu Ala Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe 
    690                 695                 700                 


Asp Asp Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val 
705                 710                 715                 720 


Ala Lys Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met 
                725                 730                 735     


Tyr Leu Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile 
            740                 745                 750         


Ala Ile His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile 
        755                 760                 765             


Pro Glu Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser 
    770                 775                 780                 


Gln Thr Leu Cys Glu Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu 
785                 790                 795                 800 


Phe Leu Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile 
                805                 810                 815     


Asn Asn Ala Asp Ser Ile Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala 
            820                 825                 830         


His Leu Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg 
        835                 840                 845             


Thr Val Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys 
    850                 855                 860                 


Ile Thr Lys Arg Glu Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr 
865                 870                 875                 880 


Glu Asp Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys 
                885                 890                 895     


Ala Leu Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu 
            900                 905                 910         


Ser Ile Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925         


<210>  3072
<211>  954
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3072

Met Gly Lys Lys Ile His Ala Arg Asp Leu Arg Glu Gln Arg Lys Thr 
1               5                   10                  15      


Asp Arg Thr Val Lys Phe Ala Asp Gln Asn Glu Lys Arg Glu Ala Gln 
            20                  25                  30          


Arg Ala Val Gln Lys Lys Asp Ala Ala Val Ser Val Lys Ser Val Ser 
        35                  40                  45              


Ser Val Ser Ser Lys Lys Asp Asn Val Thr Lys Ser Met Ala Lys Ala 
    50                  55                  60                  


Ala Gly Val Lys Ser Val Phe Ala Val Glu Asn Thr Val Tyr Met Thr 
65                  70                  75                  80  


Ser Phe Gly Arg Gly Asn Asp Ala Val Leu Glu Gln Lys Ile Val Asp 
                85                  90                  95      


Thr Ser His Glu Pro Leu Asn Ile Asp Asp Pro Ala Tyr Gln Leu Asn 
            100                 105                 110         


Val Val Thr Met Asn Gly Tyr Ser Val Thr Gly His Arg Gly Glu Thr 
        115                 120                 125             


Val Ser Ala Val Thr Asp Asn Pro Leu Arg Arg Phe Asn Gly Gly Lys 
    130                 135                 140                 


Lys Asp Glu Pro Glu Gln Ser Val Pro Thr Asp Met Leu Cys Leu Lys 
145                 150                 155                 160 


Pro Thr Leu Glu Lys Lys Phe Phe Gly Lys Glu Phe Asn Asp Asn Ile 
                165                 170                 175     


His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala 
            180                 185                 190         


Val Tyr Ser Thr Asn Ala Ile Tyr Ala Leu Asn Asn Met Ser Ala Asp 
        195                 200                 205             


Glu Asn Ile Glu Asn Ser Asp Phe Phe Met Lys Arg Thr Thr Asp Glu 
    210                 215                 220                 


Thr Phe Asp Asp Phe Glu Lys Lys Lys Glu Ser Thr Asn Ser Arg Glu 
225                 230                 235                 240 


Lys Ala Asp Phe Asp Ala Phe Glu Lys Phe Ile Gly Asn Tyr Arg Leu 
                245                 250                 255     


Ala Tyr Phe Ala Asp Ala Phe Tyr Val Asn Lys Lys Asn Pro Lys Gly 
            260                 265                 270         


Lys Ala Arg Asn Val Leu Arg Glu Asp Lys Glu Leu Tyr Ser Val Leu 
        275                 280                 285             


Thr Leu Ile Gly Lys Leu Arg His Trp Cys Val His Ser Glu Asp Gly 
    290                 295                 300                 


Arg Ala Glu Phe Trp Leu Tyr Lys Leu Asn Glu Leu Lys Asp Asp Phe 
305                 310                 315                 320 


Lys Asn Val Leu Asp Val Val Tyr Asn Arg Pro Val Glu Glu Ile Asn 
                325                 330                 335     


Asn Arg Phe Ile Glu Asn Asn Lys Val Asn Ile Gln Ile Leu Gly Ser 
            340                 345                 350         


Val Tyr Lys Asn Thr Asp Ile Ala Glu Leu Val Arg Ser Tyr Tyr Glu 
        355                 360                 365             


Phe Leu Ile Thr Lys Lys Tyr Lys Asn Met Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Ser Met Phe Glu Gly Lys Gly Tyr Ala Asp Lys Glu Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Asn Lys Leu Tyr Gln Met Thr Asp Phe Ile Leu Tyr 
                405                 410                 415     


Thr Gly Tyr Ile Asn Glu Asp Ser Asp Arg Ala Asp Asp Leu Val Asn 
            420                 425                 430         


Thr Leu Arg Ser Ser Leu Lys Glu Asp Asp Lys Thr Thr Val Tyr Cys 
        435                 440                 445             


Lys Glu Ala Asp Tyr Leu Trp Lys Lys Tyr Arg Glu Ser Ile Arg Glu 
    450                 455                 460                 


Val Ala Asp Ala Leu Asp Gly Asp Asn Ile Lys Lys Leu Ser Lys Ser 
465                 470                 475                 480 


Asn Ile Glu Ile Gln Glu Asp Lys Leu Arg Lys Cys Phe Ile Ser Tyr 
                485                 490                 495     


Ala Asp Ser Val Ser Glu Phe Thr Lys Leu Ile Tyr Leu Leu Thr Arg 
            500                 505                 510         


Phe Leu Ser Gly Lys Glu Ile Asn Asp Leu Val Thr Thr Leu Ile Asn 
        515                 520                 525             


Lys Phe Asp Asn Ile Arg Ser Phe Leu Glu Ile Met Asp Glu Leu Gly 
    530                 535                 540                 


Leu Asp Arg Thr Phe Thr Ala Glu Tyr Ser Phe Phe Glu Gly Ser Thr 
545                 550                 555                 560 


Lys Tyr Leu Ala Glu Leu Ile Glu Leu Asn Ser Phe Val Lys Ser Cys 
                565                 570                 575     


Ser Phe Asp Ile Asn Ala Lys Arg Thr Met Tyr Arg Asp Ala Leu Asp 
            580                 585                 590         


Ile Leu Gly Ile Glu Ser Gly Lys Thr Glu Glu Asp Ile Glu Lys Met 
        595                 600                 605             


Ile Asp Asn Ile Leu Gln Ile Asp Ala Asn Gly Asp Lys Lys Leu Lys 
    610                 615                 620                 


Lys Asn Asn Gly Leu Arg Asn Phe Ile Ala Ser Asn Val Ile Asp Ser 
625                 630                 635                 640 


Asn Arg Phe Lys Tyr Leu Val Arg Tyr Gly Asn Pro Lys Lys Ile Arg 
                645                 650                 655     


Glu Thr Ala Lys Cys Glu Pro Ala Val Arg Phe Val Leu Asn Glu Ile 
            660                 665                 670         


Pro Asp Ala Gln Ile Glu Arg Tyr Tyr Glu Ala Cys Cys Pro Lys Asn 
        675                 680                 685             


Thr Ala Leu Cys Ser Ala Asn Lys Arg Arg Glu Lys Leu Ala Asp Met 
    690                 695                 700                 


Ile Ala Glu Ile Glu Phe Glu Asn Phe Ser Asp Ala Gly Asn Tyr Gln 
705                 710                 715                 720 


Lys Ala Asn Val Thr Ser Arg Thr His Glu Ala Glu Ile Lys Arg Lys 
                725                 730                 735     


Asn Gln Ala Ile Ile Arg Leu Tyr Leu Thr Val Met Tyr Ile Met Leu 
            740                 745                 750         


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Phe His Cys 
        755                 760                 765             


Val Glu Arg Asp Thr Lys Leu Tyr Ala Glu Ser Gly Leu Glu Val Gly 
    770                 775                 780                 


Asn Ile Glu Lys Asn Lys Thr Asn Leu Thr Met Ala Val Met Gly Val 
785                 790                 795                 800 


Lys Leu Glu Asn Gly Ile Ile Lys Thr Glu Phe Asp Lys Ser Leu Ala 
                805                 810                 815     


Glu Asn Ala Ala Asn Arg Tyr Leu Arg Asn Ala Arg Trp Tyr Lys Leu 
            820                 825                 830         


Ile Leu Asp Asn Leu Lys Lys Ser Glu Arg Ala Val Val Asn Glu Phe 
        835                 840                 845             


Arg Asn Thr Val Cys His Leu Asn Ala Ile Arg Asn Ile Asn Ile Asn 
    850                 855                 860                 


Ile Lys Glu Ile Lys Glu Val Glu Asn Tyr Phe Ala Leu Tyr His Tyr 
865                 870                 875                 880 


Leu Ile Gln Lys His Leu Glu Asn Arg Phe Ala Asp Lys Lys Val Glu 
                885                 890                 895     


Arg Asp Thr Gly Asp Phe Ile Ser Lys Leu Glu Glu His Lys Thr Tyr 
            900                 905                 910         


Cys Lys Asp Phe Val Lys Ala Tyr Cys Thr Pro Phe Gly Tyr Asn Leu 
        915                 920                 925             


Val Arg Tyr Lys Asn Leu Thr Ile Asp Gly Leu Phe Asp Lys Asn Tyr 
    930                 935                 940                 


Pro Gly Lys Asp Asp Ser Asp Glu Gln Lys 
945                 950                 


<210>  3073
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3073

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Gln Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ser Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ser Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Lys Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Arg Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3074
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3074

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Lys Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Ala Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Pro Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Glu Arg Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ile Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3075
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3075

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asp Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Gly Asp Glu Ser His Asp Asp 
        195                 200                 205             


Ile Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe Thr Asp 
    210                 215                 220                 


Pro Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Ala Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu Tyr Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Ile Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Met Gly Ala Lys Arg Arg 
        675                 680                 685             


Glu Leu Ala Lys Met Ile Lys Ser Ile Ser Phe Glu Asp Phe Lys Asp 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Asn Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Asn Lys Tyr Ile Lys Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Asn Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3076
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3076

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Gln Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Asp Glu Ser 
        195                 200                 205             


His Asp Asp Phe Met Gly Tyr Leu Ser Ala Gln Asn Thr Tyr Tyr Ile 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val 
            260                 265                 270         


Ser Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu 
    290                 295                 300                 


Tyr Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Val Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Val Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Trp Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asp Asp Lys Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  3077
<211>  928
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3077

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Lys Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asp Tyr Asn 
                85                  90                  95      


Gln Thr Gln Leu Ser Ser Glu Asp Ser Ser Asn Ile Glu Leu Arg Gly 
            100                 105                 110         


Val Thr Lys Val Asn Ile Thr Phe Ser Ser Lys His Gly Leu Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser 
        195                 200                 205             


His Asp Asp Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val 
    210                 215                 220                 


Phe Ile Asp Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn 
225                 230                 235                 240 


Val Arg Lys Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Asn Arg Val 
            260                 265                 270         


Ser Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Cys Val Phe His Asp Leu Ser Glu His Leu Glu Tyr 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Asn Ser Lys Lys Val Tyr Arg Glu Cys 
305                 310                 315                 320 


Arg Glu Thr Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn 
                325                 330                 335     


Lys Gly Phe Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp 
            340                 345                 350         


Met Met Lys Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp 
        355                 360                 365             


Phe Ile Val Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys 
385                 390                 395                 400 


Gln Tyr Asp Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu 
                405                 410                 415     


Leu Phe Cys Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu 
            420                 425                 430         


Val Arg Lys Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile 
        435                 440                 445             


Tyr Ala Asp Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe 
    450                 455                 460                 


Glu Asn Ile Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly 
465                 470                 475                 480 


Lys Ala Asp Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys 
                485                 490                 495     


Asn Ala Ser Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr 
            500                 505                 510         


Tyr Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile 
        515                 520                 525             


Ser Lys Phe Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser 
    530                 535                 540                 


Ala Val Asp Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn 
545                 550                 555                 560 


Asp Ser Gln Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala 
                565                 570                 575     


Ser Met Arg Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp 
            580                 585                 590         


Ala Leu Thr Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile 
        595                 600                 605             


Ser Glu Ile Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu 
    610                 615                 620                 


Arg Asn Phe Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr 
625                 630                 635                 640 


Leu Ile Lys Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn 
                645                 650                 655     


Glu Lys Val Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile 
            660                 665                 670         


Glu Arg Tyr Tyr Lys Ser Cys Val Glu Val Thr Asp Met Asn Ser Ser 
        675                 680                 685             


Leu Glu Ala Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg 
    690                 695                 700                 


Phe Asp Asp Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn 
705                 710                 715                 720 


Val Ala Lys Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val 
                725                 730                 735     


Met Tyr Leu Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val 
            740                 745                 750         


Ile Ala Ile His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile 
        755                 760                 765             


Ile Pro Glu Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu 
    770                 775                 780                 


Ser Gln Thr Leu Cys Glu Leu Cys Asp Asp Arg Asp Lys Ser Pro Asn 
785                 790                 795                 800 


Leu Phe Leu Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp 
                805                 810                 815     


Ile Asn Asn Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile 
            820                 825                 830         


Ala His Leu Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile 
        835                 840                 845             


Arg Thr Val Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg 
    850                 855                 860                 


Cys Ile Thr Lys Arg Glu Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys 
865                 870                 875                 880 


Tyr Glu Asp Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val 
                885                 890                 895     


Lys Ala Leu Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn 
            900                 905                 910         


Leu Ser Ile Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925             


<210>  3078
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3078

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys Arg Gly Asn Glu Gly 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Lys Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Ala Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Thr Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Thr Tyr Ala Asp 
        435                 440                 445             


Glu Ala Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Gly His Met Asn Gly Asp Ala Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asp Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  3079
<211>  926
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3079

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Val Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Lys Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asp Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asp Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Lys Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Asn Ala 
            260                 265                 270         


Leu Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu His Glu 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Asp Asp Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile 
        355                 360                 365             


Val Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg 
    370                 375                 380                 


Glu Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe 
                405                 410                 415     


Cys Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg 
            420                 425                 430         


Lys Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala 
        435                 440                 445             


Asp Glu Ala Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn 
    450                 455                 460                 


Ile Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala 
465                 470                 475                 480 


Asp Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala 
                485                 490                 495     


Ser Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe 
            500                 505                 510         


Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys 
        515                 520                 525             


Phe Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val 
    530                 535                 540                 


Asn Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser 
545                 550                 555                 560 


Gln Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met 
                565                 570                 575     


Arg Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu 
            580                 585                 590         


Thr Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu 
        595                 600                 605             


Ile Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn 
    610                 615                 620                 


Phe Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile 
625                 630                 635                 640 


Lys Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys 
                645                 650                 655     


Val Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg 
            660                 665                 670         


Tyr Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu 
        675                 680                 685             


Ala Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp 
    690                 695                 700                 


Asp Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala 
705                 710                 715                 720 


Lys Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr 
                725                 730                 735     


Leu Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala 
            740                 745                 750         


Ile His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro 
        755                 760                 765             


Glu Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln 
    770                 775                 780                 


Thr Leu Cys Glu Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe 
785                 790                 795                 800 


Leu Lys Lys Asn Arg Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn 
                805                 810                 815     


Asn Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His 
            820                 825                 830         


Leu Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr 
        835                 840                 845             


Val Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile 
    850                 855                 860                 


Thr Lys Arg Glu Asp Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu 
865                 870                 875                 880 


Asp Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala 
                885                 890                 895     


Leu Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser 
            900                 905                 910         


Ile Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925     


<210>  3080
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3080

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Ile Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Pro Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn His Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3081
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3081

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Lys Asn Asp Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Val 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Glu Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Asp Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Gly Asp Glu Ser His Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe Thr Asp 
    210                 215                 220                 


Pro Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu Tyr Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Val Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Ile Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Glu 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Arg Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3082
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3082

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Val Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Gly Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asp Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Glu Asp Ser Ser Asn Ile Glu Leu Cys Gly 
            100                 105                 110         


Val Thr Lys Val Asn Ile Thr Phe Ser Ser Lys His Gly Leu Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Tyr Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Leu Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Ile Ile Asp Pro Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Lys 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ile Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Ala Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3083
<211>  921
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3083

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Lys Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Val 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys Arg Gly Asn Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn 
        195                 200                 205             


Tyr Asp Phe Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe 
    210                 215                 220                 


Thr Asn Pro Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile 
225                 230                 235                 240 


Arg Lys Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu 
                245                 250                 255     


Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser 
            260                 265                 270         


Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln 
        275                 280                 285             


Ile Arg Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp 
    290                 295                 300                 


Leu Tyr Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu 
305                 310                 315                 320 


Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile 
                325                 330                 335     


Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly 
            340                 345                 350         


Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu 
        355                 360                 365             


Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys 
    370                 375                 380                 


Met Leu Glu Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp Ser 
385                 390                 395                 400 


Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn 
                405                 410                 415     


Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu 
            420                 425                 430         


Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu 
        435                 440                 445             


Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala 
    450                 455                 460                 


Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met 
465                 470                 475                 480 


Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp 
                485                 490                 495     


Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp 
            500                 505                 510         


Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp 
        515                 520                 525             


Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val 
    530                 535                 540                 


Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg 
545                 550                 555                 560 


Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys 
                565                 570                 575     


Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile 
            580                 585                 590         


Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu 
        595                 600                 605             


Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile 
    610                 615                 620                 


Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr 
625                 630                 635                 640 


Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val 
                645                 650                 655     


Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr 
            660                 665                 670         


Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Gly Val Lys 
        675                 680                 685             


Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe 
    690                 695                 700                 


Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu 
705                 710                 715                 720 


Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu 
                725                 730                 735     


Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His 
            740                 745                 750         


Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu 
        755                 760                 765             


Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu 
    770                 775                 780                 


Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu 
785                 790                 795                 800 


Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser 
                805                 810                 815     


Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg 
            820                 825                 830         


Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe 
        835                 840                 845             


Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp 
    850                 855                 860                 


Asp Ile Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys 
865                 870                 875                 880 


Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe 
                885                 890                 895     


Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe 
            900                 905                 910         


Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920     


<210>  3084
<211>  924
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3084

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Phe Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Leu Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Leu Ser Glu His Ser Glu Tyr Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asp Asn Ser Lys Lys Val Tyr Arg Glu Cys Arg Glu Thr Leu 
305                 310                 315                 320 


Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile 
                325                 330                 335     


Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly 
            340                 345                 350         


Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu 
        355                 360                 365             


Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys 
    370                 375                 380                 


Ile Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser 
385                 390                 395                 400 


Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn 
                405                 410                 415     


Tyr Tyr Arg Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu 
            420                 425                 430         


Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu 
        435                 440                 445             


Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala 
    450                 455                 460                 


Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met 
465                 470                 475                 480 


Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp 
                485                 490                 495     


Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp 
            500                 505                 510         


Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp 
        515                 520                 525             


Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val 
    530                 535                 540                 


Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg 
545                 550                 555                 560 


Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys 
                565                 570                 575     


Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile 
            580                 585                 590         


Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu 
        595                 600                 605             


Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile 
    610                 615                 620                 


Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr 
625                 630                 635                 640 


Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val 
                645                 650                 655     


Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr 
            660                 665                 670         


Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys 
        675                 680                 685             


Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe 
    690                 695                 700                 


Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu 
705                 710                 715                 720 


Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu 
                725                 730                 735     


Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His 
            740                 745                 750         


Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu 
        755                 760                 765             


Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu 
    770                 775                 780                 


Cys Glu Leu Cys Asp Asn Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys 
785                 790                 795                 800 


Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala 
                805                 810                 815     


Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr 
            820                 825                 830         


Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp 
        835                 840                 845             


Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys 
    850                 855                 860                 


Arg Glu Asp Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp 
865                 870                 875                 880 


Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn 
                885                 890                 895     


Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu 
            900                 905                 910         


Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 


<210>  3085
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3085

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Gln Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Ser Val Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Gln Asn Thr Tyr Tyr Ile 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val 
            260                 265                 270         


Ser Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu 
    290                 295                 300                 


Tyr Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Val Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Ile Ala Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Leu Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Val Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Asn Arg Asp Glu Ser Pro Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asp Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  3086
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3086

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Asp Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Lys 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Leu Glu Asn Glu Ser Asn Asn Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe Thr Asp Pro 
    210                 215                 220                 


Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn Ile Lys Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu Tyr Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Ile Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Asp Asp Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Ile Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Arg Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3087
<211>  918
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3087

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Arg Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Gly Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Asn Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Glu 
    370                 375                 380                 


Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ser Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ser 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Lys Val Ala Lys Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu Arg 
785                 790                 795                 800 


Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr Arg 
                805                 810                 815     


Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu Lys 
            820                 825                 830         


Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile Tyr 
        835                 840                 845             


His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp Asp Lys Lys 
    850                 855                 860                 


Gln Glu Glu Lys Ile Lys Phe Glu Asp Asp Leu Leu Lys Asn His Gly 
865                 870                 875                 880 


Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr Asn 
                885                 890                 895     


Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg Asn 
            900                 905                 910         


Glu Tyr Leu Thr Glu Lys 
        915             


<210>  3088
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3088

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asp Tyr Asn 
                85                  90                  95      


Gln Thr Gln Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val 
    210                 215                 220                 


Phe Thr Asp Pro Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Cys Val Phe His Asp Leu Ser Glu His Ser Glu Tyr 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Asn Ser Lys Lys Val Tyr Arg Glu Cys 
305                 310                 315                 320 


Arg Glu Thr Leu Asn Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn 
                325                 330                 335     


Lys Gly Phe Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp 
            340                 345                 350         


Met Met Lys Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp 
        355                 360                 365             


Phe Ile Val Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys 
385                 390                 395                 400 


Gln Tyr Asp Pro Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu 
                405                 410                 415     


Leu Phe Cys Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu 
            420                 425                 430         


Val Arg Lys Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile 
        435                 440                 445             


Tyr Ala Asp Glu Ala Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe 
    450                 455                 460                 


Glu Asn Ile Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly 
465                 470                 475                 480 


Lys Ala Asp Met Asp Phe Asp Glu Lys Ile Ile Asp Ser Glu Lys Lys 
                485                 490                 495     


Asn Ala Ser Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr 
            500                 505                 510         


Tyr Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile 
        515                 520                 525             


Ser Lys Phe Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser 
    530                 535                 540                 


Ala Val Asn Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn 
545                 550                 555                 560 


Asp Ser Gln Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala 
                565                 570                 575     


Ser Met Arg Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp 
            580                 585                 590         


Ala Leu Thr Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile 
        595                 600                 605             


Ser Glu Ile Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu 
    610                 615                 620                 


Arg Asn Phe Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr 
625                 630                 635                 640 


Leu Ile Lys Tyr Ala Asn Ala Gln Lys Ile Arg Lys Val Ala Glu Asn 
                645                 650                 655     


Glu Lys Val Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile 
            660                 665                 670         


Glu Arg Tyr Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser 
        675                 680                 685             


Leu Glu Ala Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser 
    690                 695                 700                 


Phe Asp Asp Phe Lys Lys Val Lys Gln Gln Ala Lys Gly Arg Glu Asn 
705                 710                 715                 720 


Val Ala Lys Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val 
                725                 730                 735     


Met Tyr Leu Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val 
            740                 745                 750         


Ile Ala Ile His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile 
        755                 760                 765             


Ile Pro Glu Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu 
    770                 775                 780                 


Ser Gln Lys Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Ile Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  3089
<211>  954
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3089

Met Gly Lys Lys Ile His Ala Arg Asp Leu Arg Glu Gln Arg Lys Thr 
1               5                   10                  15      


Asp Arg Thr Glu Lys Phe Ala Asp Gln Asn Lys Lys Arg Glu Ala Glu 
            20                  25                  30          


Arg Ala Val Gln Lys Lys Asp Ala Ala Val Ser Val Lys Ser Val Ser 
        35                  40                  45              


Ser Val Ser Ser Lys Lys Asp Asn Val Thr Lys Ser Met Ala Lys Ala 
    50                  55                  60                  


Ala Gly Val Lys Ser Val Phe Ala Val Gly Asn Thr Val Tyr Met Thr 
65                  70                  75                  80  


Ser Phe Gly Arg Gly Asn Asp Ala Val Leu Glu Gln Lys Ile Val Asp 
                85                  90                  95      


Thr Ser His Glu Pro Leu Asn Ile Asp Asp Pro Ala Tyr Gln Leu Asn 
            100                 105                 110         


Val Val Thr Met Asn Gly Tyr Ser Val Thr Gly His Arg Gly Glu Thr 
        115                 120                 125             


Val Ser Ala Val Thr Asp Asn Pro Leu Arg Arg Phe Asn Gly Gly Lys 
    130                 135                 140                 


Lys Asp Glu Pro Glu Gln Ser Val Pro Thr Asp Met Leu Cys Leu Lys 
145                 150                 155                 160 


Pro Thr Leu Glu Lys Lys Phe Phe Gly Lys Glu Phe Asn Asp Asn Ile 
                165                 170                 175     


His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala 
            180                 185                 190         


Val Tyr Ser Thr Asn Ala Ile Tyr Ala Leu Asn Asn Met Ser Ala Asp 
        195                 200                 205             


Glu Asn Ile Glu Asn Ser Asp Phe Phe Met Lys Arg Thr Thr Asp Glu 
    210                 215                 220                 


Thr Phe Asp Asp Phe Glu Lys Lys Lys Glu Ser Thr Asn Ser Arg Glu 
225                 230                 235                 240 


Lys Ala Asp Phe Asp Ala Phe Glu Lys Phe Ile Gly Asn Tyr Arg Leu 
                245                 250                 255     


Ala Tyr Phe Ala Asp Ala Phe Tyr Val Asn Lys Lys Asn Pro Lys Gly 
            260                 265                 270         


Lys Ala Lys Asn Val Leu Arg Glu Asp Lys Glu Leu Tyr Ser Val Leu 
        275                 280                 285             


Thr Leu Ile Gly Lys Leu Arg His Trp Cys Val His Ser Glu Glu Gly 
    290                 295                 300                 


Arg Ala Glu Phe Trp Leu Tyr Lys Leu Asn Glu Leu Lys Asp Asp Phe 
305                 310                 315                 320 


Lys Asn Val Leu Asp Val Val Tyr Asn Arg Pro Val Glu Glu Ile Asn 
                325                 330                 335     


Asn Arg Phe Ile Glu Asn Asn Lys Val Asn Ile Gln Ile Leu Gly Ser 
            340                 345                 350         


Val Tyr Lys Asn Thr Asp Ile Ala Glu Leu Val Arg Ser Tyr Tyr Glu 
        355                 360                 365             


Phe Leu Ile Thr Lys Lys Tyr Lys Asn Met Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Ser Met Leu Glu Gly Lys Gly Tyr Ala Asp Lys Glu Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Asn Lys Leu Tyr Gln Met Thr Asp Phe Ile Leu Tyr 
                405                 410                 415     


Thr Gly Tyr Ile Asn Glu Asp Ser Asp Arg Ala Asp Asp Leu Val Asn 
            420                 425                 430         


Thr Leu Arg Ser Ser Leu Lys Glu Asp Asp Lys Thr Thr Val Tyr Cys 
        435                 440                 445             


Lys Glu Ala Asp Tyr Leu Trp Lys Lys Tyr Cys Glu Ser Ile Arg Glu 
    450                 455                 460                 


Val Ala Glu Ala Leu Asp Gly Asp Asn Ile Lys Arg Leu Ser Lys Ser 
465                 470                 475                 480 


Asn Ile Glu Ile Arg Asp Asn Glu Leu Arg Lys Cys Phe Ile Ser Tyr 
                485                 490                 495     


Ala Asp Ser Val Ser Glu Phe Thr Lys Leu Ile Tyr Leu Leu Thr Arg 
            500                 505                 510         


Phe Leu Ser Gly Lys Glu Ile Asn Asp Leu Val Thr Thr Leu Ile Asn 
        515                 520                 525             


Lys Phe Asp Asn Ile Arg Ser Phe Leu Glu Ile Leu Asp Glu Leu Gly 
    530                 535                 540                 


Leu Asp Arg Thr Phe Thr Ala Glu Tyr Ser Phe Phe Glu Gly Ser Thr 
545                 550                 555                 560 


Lys Tyr Leu Ala Glu Leu Val Glu Leu Asn Ser Phe Val Lys Ser Cys 
                565                 570                 575     


Ser Phe Asp Ile Asn Ala Lys Arg Thr Met Tyr Arg Asp Ala Leu Asp 
            580                 585                 590         


Ile Leu Gly Ile Lys Ser Gly Lys Thr Glu Glu Asp Ile Glu Lys Met 
        595                 600                 605             


Ile Asp Asn Ile Leu Gln Ile Asp Ala Asn Gly Asp Lys Lys Leu Lys 
    610                 615                 620                 


Lys Asn Asn Gly Leu Arg Asn Phe Ile Ala Ser Asn Val Ile Asp Ser 
625                 630                 635                 640 


Asn Arg Phe Lys Tyr Leu Val Arg Tyr Gly Asn Pro Lys Lys Ile Arg 
                645                 650                 655     


Glu Thr Ala Lys Cys Lys Pro Ala Val Arg Phe Val Leu Asn Glu Ile 
            660                 665                 670         


Pro Asp Ala Gln Ile Glu Arg Tyr Tyr Glu Ala Cys Cys Pro Lys Asn 
        675                 680                 685             


Thr Ala Leu Cys Ser Ala Asn Lys Arg Arg Glu Lys Leu Ala Asp Met 
    690                 695                 700                 


Ile Ala Glu Ile Lys Phe Glu Asn Phe Ser Asp Ala Gly Asn Tyr Gln 
705                 710                 715                 720 


Lys Ala Asn Val Thr Ser Lys Thr His Glu Ala Glu Ile Lys Arg Lys 
                725                 730                 735     


Asn Gln Ala Ile Ile Arg Leu Tyr Leu Thr Val Met Tyr Ile Met Leu 
            740                 745                 750         


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Phe His Cys 
        755                 760                 765             


Val Glu Arg Asp Thr Lys Leu Tyr Ala Glu Ser Gly Leu Glu Val Gly 
    770                 775                 780                 


Asn Ile Glu Lys Asn Lys Thr Asn Leu Thr Met Ala Val Met Gly Val 
785                 790                 795                 800 


Lys Leu Glu Asn Gly Ile Ile Lys Thr Glu Phe Asp Lys Ser Leu Ala 
                805                 810                 815     


Glu Asn Ala Ala Asn Arg Tyr Leu Arg Asn Ala Arg Trp Tyr Lys Leu 
            820                 825                 830         


Ile Leu Asp Asn Leu Lys Lys Ser Glu Arg Ala Val Val Asn Glu Phe 
        835                 840                 845             


Arg Asn Thr Val Cys His Leu Asn Ala Ile Arg Asn Ile Asn Ile Asn 
    850                 855                 860                 


Ile Asp Gly Ile Lys Glu Val Glu Asn Tyr Phe Ala Leu Tyr His Tyr 
865                 870                 875                 880 


Leu Ile Gln Lys His Leu Glu Asn Arg Phe Ala Asp Lys Lys Val Glu 
                885                 890                 895     


Arg Asp Thr Gly Asp Phe Ile Ser Lys Leu Glu Glu His Lys Thr Tyr 
            900                 905                 910         


Cys Lys Asp Phe Val Lys Ala Tyr Cys Thr Pro Phe Gly Tyr Asn Leu 
        915                 920                 925             


Val Arg Tyr Lys Asn Leu Thr Ile Asp Gly Leu Phe Asp Lys Asn Tyr 
    930                 935                 940                 


Pro Gly Lys Asp Asp Ser Asp Lys Gln Lys 
945                 950                 


<210>  3090
<211>  918
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3090

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys Arg Gly Asn Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp 
    370                 375                 380                 


Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Gly Val Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu Arg 
785                 790                 795                 800 


Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr Arg 
                805                 810                 815     


Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu Lys 
            820                 825                 830         


Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile Tyr 
        835                 840                 845             


His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp Asp Ile Lys 
    850                 855                 860                 


Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His Gly 
865                 870                 875                 880 


Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr Asn 
                885                 890                 895     


Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg Asn 
            900                 905                 910         


Glu Tyr Leu Thr Glu Lys 
        915             


<210>  3091
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3091

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Phe Lys Gly Ser Ser Asn Ile Glu Leu Arg Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Ile Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Ile Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Arg Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3092
<211>  918
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3092

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Arg Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Gly Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Asn Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Glu 
    370                 375                 380                 


Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ser Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ser 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Lys Val Ala Lys Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu Arg 
785                 790                 795                 800 


Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr Arg 
                805                 810                 815     


Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu Lys 
            820                 825                 830         


Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile Tyr 
        835                 840                 845             


His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp Asp Lys Lys 
    850                 855                 860                 


Gln Glu Glu Lys Ile Lys Phe Glu Asp Asp Leu Leu Lys Asn His Gly 
865                 870                 875                 880 


Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr Asn 
                885                 890                 895     


Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg Asn 
            900                 905                 910         


Glu Tyr Leu Thr Glu Lys 
        915             


<210>  3093
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3093

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Ile Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Pro Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn His Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Val Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3094
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3094

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asn Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Glu Gly Ser Ser Asn Ile Glu Leu Arg Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Lys Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Ala Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Thr Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Thr Tyr Ala Asp Glu Ala Glu 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Val Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Gln Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Ser Glu 
    850                 855                 860                 


Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Phe Thr Glu Lys 
        915                 920         


<210>  3095
<211>  1023
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3095

Met Ala Lys Lys Ile Thr Ala Lys Gln Lys Arg Glu Glu Lys Glu Arg 
1               5                   10                  15      


Leu Asn Lys Gln Lys Trp Ala Lys Asn Asp Ser Val Ile Ile Val Pro 
            20                  25                  30          


Glu Thr Lys Glu Glu Ile Lys Thr Gly Glu Ile Gln Asp Asn Asn Arg 
        35                  40                  45              


Lys Arg Ser Arg Gln Lys Ser Gln Ala Lys Ala Met Gly Leu Lys Ala 
    50                  55                  60                  


Val Leu Ser Phe Asp Asn Lys Ile Ala Ile Ala Ser Phe Val Ser Ser 
65                  70                  75                  80  


Lys Asn Ala Lys Ser Ser His Ile Glu Arg Ile Thr Asp Lys Glu Gly 
                85                  90                  95      


Thr Thr Ile Ser Val Asn Ser Lys Met Phe Glu Ser Ser Val Asn Lys 
            100                 105                 110         


Arg Asp Ile Asn Ile Glu Lys Arg Ile Thr Ile Glu Glu Pro Gln Gln 
        115                 120                 125             


Asp Gly Thr Ile Lys Lys Glu Glu Lys Gly Val Lys Ser Thr Thr Cys 
    130                 135                 140                 


Asn Pro Tyr Phe Lys Val Gly Gly Lys Asp Tyr Ile Gly Ile Lys Glu 
145                 150                 155                 160 


Ile Ala Glu Glu His Phe Phe Gly Arg Ala Phe Pro Asn Glu Asn Leu 
                165                 170                 175     


Arg Val Gln Ile Ala Tyr Asn Ile Phe Asp Val Gln Lys Ile Leu Gly 
            180                 185                 190         


Thr Phe Val Asn Asn Ile Ile Tyr Ser Phe Tyr Asn Leu Ser Arg Asp 
        195                 200                 205             


Glu Val Gln Ser Asp Asn Asp Val Ile Gly Met Leu Tyr Ser Ile Ser 
    210                 215                 220                 


Asp Tyr Asp Arg Gln Lys Glu Thr Glu Thr Phe Leu Gln Ala Lys Ser 
225                 230                 235                 240 


Leu Leu Lys Gln Thr Glu Ala Tyr Tyr Ala Tyr Phe Asp Asp Val Phe 
                245                 250                 255     


Lys Lys Asn Lys Lys Pro Asp Lys Asn Lys Glu Gly Asp Asn Ser Lys 
            260                 265                 270         


Gln Tyr Gln Glu Asn Leu Arg His Asn Phe Asn Ile Leu Arg Val Leu 
        275                 280                 285             


Ser Phe Leu Arg Gln Ile Cys Met His Ala Glu Val His Val Ser Asp 
    290                 295                 300                 


Asp Glu Gly Cys Ala Arg Thr Gln Asn Tyr Thr Asp Ser Leu Glu Ala 
305                 310                 315                 320 


Leu Phe Asn Ile Ser Lys Ala Phe Gly Lys Lys Met Pro Glu Leu Lys 
                325                 330                 335     


Thr Leu Ile Asp Asn Ile Tyr Ser Lys Gly Ile Asn Ala Ile Asn Asp 
            340                 345                 350         


Glu Phe Val Lys Asn Gly Lys Asn Asn Leu Tyr Ile Leu Ser Lys Val 
        355                 360                 365             


Tyr Pro Asn Glu Lys Arg Glu Val Leu Leu Arg Glu Tyr Tyr Asn Phe 
    370                 375                 380                 


Val Val Cys Lys Glu Gly Ser Asn Ile Gly Ile Ser Thr Arg Lys Leu 
385                 390                 395                 400 


Lys Glu Thr Met Ile Ala Gln Asn Met Pro Ser Leu Lys Glu Glu Asn 
                405                 410                 415     


Thr Tyr Arg Asn Lys Leu Tyr Thr Val Met Asn Phe Ile Leu Val Arg 
            420                 425                 430         


Glu Leu Lys Asn Cys Ala Thr Ile Arg Glu Gln Met Ile Lys Glu Leu 
        435                 440                 445             


Arg Ala Asn Met Asp Glu Glu Glu Gly Arg Asp Arg Ile Tyr Ser Lys 
    450                 455                 460                 


Tyr Ala Lys Glu Ile Tyr Leu Tyr Val Lys Asp Lys Leu Lys Leu Met 
465                 470                 475                 480 


Leu Asn Val Phe Lys Glu Glu Ala Glu Gly Ile Ile Ile Pro Gly Lys 
                485                 490                 495     


Glu Asp Pro Val Lys Phe Ser His Gly Lys Leu Asp Lys Lys Glu Ile 
            500                 505                 510         


Glu Ser Phe Cys Leu Thr Thr Lys Asn Thr Glu Asp Ile Thr Lys Val 
        515                 520                 525             


Ile Tyr Phe Leu Cys Lys Phe Leu Asp Gly Lys Glu Ile Asn Glu Leu 
    530                 535                 540                 


Cys Cys Ala Met Met Asn Lys Leu Asp Gly Ile Ser Asp Leu Ile Glu 
545                 550                 555                 560 


Thr Ala Lys Gln Cys Gly Glu Asp Val Glu Phe Val Asp Gln Phe Lys 
                565                 570                 575     


Cys Leu Ser Lys Cys Ala Thr Met Ser Asn Gln Ile Arg Ile Val Lys 
            580                 585                 590         


Asn Ile Ser Arg Met Lys Lys Glu Met Thr Ile Asp Asn Asp Thr Ile 
        595                 600                 605             


Phe Leu Asp Ala Leu Glu Leu Leu Gly Arg Lys Ile Glu Lys Tyr Gln 
    610                 615                 620                 


Lys Asp Lys Asn Gly Asp Tyr Val Lys Asp Glu Lys Gly Lys Lys Val 
625                 630                 635                 640 


Tyr Thr Lys Asp Tyr Asn Asn Phe Gln Asp Met Phe Phe Glu Gly Lys 
                645                 650                 655     


Asn His Arg Val Arg Asn Phe Val Ser Asn Asn Val Ile Lys Ser Lys 
            660                 665                 670         


Trp Phe Ser Tyr Val Val Arg Tyr Asn Lys Pro Ala Glu Cys Gln Ala 
        675                 680                 685             


Leu Met Arg Asn Ser Lys Leu Val Lys Phe Ala Leu Asp Glu Leu Pro 
    690                 695                 700                 


Asp Ser Gln Ile Glu Lys Tyr Tyr Ile Ser Val Phe Gly Glu Lys Ser 
705                 710                 715                 720 


Ser Ser Ser Asn Glu Glu Met Arg Arg Glu Leu Leu Lys Lys Leu Cys 
                725                 730                 735     


Asp Phe Ser Val Arg Gly Phe Leu Asp Glu Ile Val Leu Leu Ser Glu 
            740                 745                 750         


Asp Glu Met Lys Gln Lys Asp Lys Phe Ser Glu Lys Glu Lys Lys Lys 
        755                 760                 765             


Ser Leu Ile Arg Leu Tyr Leu Thr Ile Val Tyr Leu Ile Thr Lys Ser 
    770                 775                 780                 


Met Val Lys Ile Asn Thr Arg Phe Ser Ile Ala Cys Ala Thr Tyr Glu 
785                 790                 795                 800 


Arg Asp Tyr Ile Leu Leu Cys Gln Ser Glu Lys Ala Glu Arg Ala Trp 
                805                 810                 815     


Glu Lys Gly Ala Thr Ala Phe Ala Leu Thr Arg Lys Phe Leu Asn His 
            820                 825                 830         


Asp Lys Pro Thr Phe Glu Gln Tyr Tyr Thr Arg Glu Arg Glu Ile Ser 
        835                 840                 845             


Ala Met Pro Gln Glu Lys Arg Lys Glu Leu Arg Lys Glu Asn Asp Gln 
    850                 855                 860                 


Leu Leu Lys Lys Thr His Tyr Ser Lys His Ala Tyr Cys Tyr Ile Val 
865                 870                 875                 880 


Asp Asn Val Asn Asn Leu Thr Gly Ala Val Ala Asn Asp Asn Gly Arg 
                885                 890                 895     


Gly Leu Pro Cys Leu Ser Glu Lys Asn Asp Asn Ala Asn Leu Phe Val 
            900                 905                 910         


Glu Met Arg Asn Lys Ile Val His Leu Asn Val Val His Asp Met Val 
        915                 920                 925             


Lys Tyr Ile Asn Glu Ile Lys Asn Ile Thr Ser Tyr Tyr Ala Phe Phe 
    930                 935                 940                 


Cys Tyr Val Leu Gln Arg Met Ile Ile Gly Asn Asn Ser Asn Glu Gln 
945                 950                 955                 960 


Asn Lys Phe Lys Ala Lys Tyr Ser Lys Thr Leu Gln Glu Phe Gly Thr 
                965                 970                 975     


Tyr Ser Lys Asp Leu Met Trp Val Leu Asn Leu Pro Phe Ala Tyr Asn 
            980                 985                 990         


Leu Pro Arg Tyr Lys Asn Leu Ser  Asn Glu Gln Leu Phe  Tyr Asp Glu 
        995                 1000                 1005             


Glu Glu  Arg Met Glu Lys Ile  Val Gly Arg Lys Asn  Asp Ser Arg 
    1010                 1015                 1020             


<210>  3096
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3096

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Glu Ser Ser Ser Asn Ile Glu Leu Cys Gly 
            100                 105                 110         


Val Thr Lys Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Gln Asn Thr Tyr Tyr Ile 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe 
    290                 295                 300                 


Asp Ile Tyr Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Tyr Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Val Pro Asp Met Asn Ser Ser Leu Glu Ala 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asp Leu Leu Lys Asn His Gly Tyr Thr Arg Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  3097
<211>  939
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3097

Met Ala Lys Lys Lys Arg Ile Thr Ala Lys Glu Arg Lys Gln Asn His 
1               5                   10                  15      


Arg Glu Ser Leu Met Lys Lys Ala Asp Ser Asn Ala Glu Lys Glu Lys 
            20                  25                  30          


Ala Lys Lys Pro Val Val Glu Asn Lys Pro Asp Thr Ala Ile Ser Lys 
        35                  40                  45              


Asp Asn Thr Pro Lys Pro Asn Lys Glu Ile Lys Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Ala Gly Val Lys Trp Val Ile Lys Ala Asn Asp Asp Val Ala Tyr 
65                  70                  75                  80  


Ile Ser Ser Phe Gly Lys Gly Asn Asn Ser Val Leu Glu Lys Arg Ile 
                85                  90                  95      


Met Gly Asp Val Ser Ser Asn Val Asn Lys Asp Ser His Met Tyr Val 
            100                 105                 110         


Asn Pro Lys Tyr Thr Lys Lys Asn Tyr Glu Ile Lys Asn Gly Phe Ser 
        115                 120                 125             


Ser Gly Ser Ser Leu Val Thr Tyr Pro Asn Lys Pro Asp Lys Asn Ser 
    130                 135                 140                 


Gly Met Asp Ala Leu Cys Leu Lys Pro Tyr Phe Glu Lys Asp Phe Phe 
145                 150                 155                 160 


Gly His Ile Phe Thr Asp Asn Met His Ile Gln Ala Ile Tyr Asn Ile 
                165                 170                 175     


Phe Asp Ile Glu Lys Ile Leu Ala Lys His Ile Thr Asn Ile Ile Tyr 
            180                 185                 190         


Thr Val Asn Ser Phe Asp Arg Asn Tyr Asn Gln Ser Gly Asn Asp Thr 
        195                 200                 205             


Ile Gly Phe Asp Ile Asn Tyr Arg Val Pro Tyr Ser Glu Tyr Gly Gly 
    210                 215                 220                 


Gly Lys Asp Ser Asn Gly Lys Pro Asn Lys Ile Ser Ala Trp Lys Lys 
225                 230                 235                 240 


Arg Glu Asn Phe Ile Lys Phe Tyr Asn Glu Ala Lys Pro His Leu Gly 
                245                 250                 255     


Tyr Tyr Glu Asn Ile Phe Tyr Glu His Gly Glu Pro Ile Ser Glu Glu 
            260                 265                 270         


Lys Phe Tyr Asn Tyr Leu Asn Ile Leu Asn Phe Ile Arg Asn Asn Thr 
        275                 280                 285             


Phe His Tyr Lys Asp Asn Asp Ile Glu Leu Tyr Gly Glu Asn Tyr Ser 
    290                 295                 300                 


Glu Glu Tyr Val Phe Ile Asn Cys Leu Asn Glu Phe Val Lys Asn Lys 
305                 310                 315                 320 


Phe Lys Asn Val Asn Lys Asn Phe Ile Ser Asn Glu Lys Asn Asn Leu 
                325                 330                 335     


Tyr Ile Ile Leu Lys Ala Tyr Gly Glu Asp Thr Glu Asn Val Glu Val 
            340                 345                 350         


Val Lys Lys Tyr Ser Lys Glu Leu Tyr Lys Leu Ser Val Leu Lys Thr 
        355                 360                 365             


Asn Lys Asn Leu Gly Val Asn Val Lys Lys Leu Arg Glu Ser Ala Ile 
    370                 375                 380                 


Glu Tyr Gly Tyr Cys Pro Leu Pro Tyr Asp Lys Glu Lys Glu Val Ala 
385                 390                 395                 400 


Lys Leu Ser Ser Val Lys His Lys Leu Tyr Lys Thr Tyr Asp Phe Val 
                405                 410                 415     


Ile Thr His Tyr Leu Asn Ser Asn Asp Lys Leu Leu Leu Glu Ile Val 
            420                 425                 430         


Glu Thr Leu Arg Leu Ser Lys Asn Asp Asp Glu Lys Glu Asn Val Tyr 
        435                 440                 445             


Lys Lys Tyr Ala Glu Lys Leu Phe Lys Ala Asp Asp Val Ile Asn Pro 
    450                 455                 460                 


Ile Lys Ala Ile Ser Lys Leu Phe Ala Glu Lys Gly Asn Lys Leu Phe 
465                 470                 475                 480 


Lys Glu Lys Ile Ile Ile Lys Lys Glu Tyr Ile Glu Asp Val Ser Ile 
                485                 490                 495     


Asp Lys Asn Ile Tyr Asp Phe Thr Lys Val Ile Phe Phe Met Thr Cys 
            500                 505                 510         


Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Asn Ile Ile Ser 
        515                 520                 525             


Lys Leu Gln Ile Ile Glu Asp His Asn Asn Val Ile Lys Phe Ile Ala 
    530                 535                 540                 


Glu Asn Asp Asp Ala Val Tyr Lys Asp Tyr Ser Asp Lys Tyr Ala Ile 
545                 550                 555                 560 


Phe Arg Asn Ala Gly Lys Ile Ala Thr Glu Leu Glu Ala Ile Lys Ser 
                565                 570                 575     


Ile Ala Arg Met Glu Asn Lys Ile Glu Asn Val Pro Gln Lys Pro Leu 
            580                 585                 590         


Leu Lys Asp Ala Leu Leu Ser Leu Gly Val Ser Asp Asp Thr Lys Val 
        595                 600                 605             


Leu Glu Asn Thr Tyr Asn Lys Tyr Phe Asp Ser Lys Glu Lys Ala Asp 
    610                 615                 620                 


Lys Gln Ser Gln Lys Val Ser Thr Phe Leu Met Asn Asn Val Ile Asn 
625                 630                 635                 640 


Asn Asn Arg Phe Lys Tyr Val Ile Lys Tyr Ile Asn Pro Ala Asp Ile 
                645                 650                 655     


Asn Gly Leu Ala Lys Asn Arg Tyr Leu Val Lys Phe Val Leu Ser Lys 
            660                 665                 670         


Ile Pro Glu Glu Gln Ile Asp Ser Tyr Tyr Lys Leu Phe Ser Asn Glu 
        675                 680                 685             


Glu Glu Pro Ser Cys Glu Glu Lys Ile Lys Leu Leu Thr Lys Lys Ile 
    690                 695                 700                 


Ser Lys Leu Asn Phe Gln Thr Leu Phe Glu Asn Asn Lys Ile Pro Asn 
705                 710                 715                 720 


Val Glu Lys Glu Arg Lys Lys Ala Ile Ile Thr Leu Tyr Phe Thr Ile 
                725                 730                 735     


Val Tyr Ile Leu Val Lys Asn Leu Val Asn Ile Asn Gly Leu Tyr Thr 
            740                 745                 750         


Leu Ala Leu Tyr Phe Val Glu Arg Asp Gly Tyr Phe Tyr Lys Asp Ile 
        755                 760                 765             


Cys Gly Lys Lys Asp Lys Lys Lys Ser Tyr Asn Asp Val Asp Tyr Leu 
    770                 775                 780                 


Leu Leu Ser Glu Ile Phe Ser Gly Ser Lys Tyr Arg Glu Glu Thr Lys 
785                 790                 795                 800 


Asn Leu Lys Leu Pro Lys Glu Lys Asp Arg Asp Ile Met Lys Lys Tyr 
                805                 810                 815     


Leu Pro Asn Asp Lys Asp Arg Glu Lys Tyr Asn Lys Phe Phe Thr Ala 
            820                 825                 830         


Tyr Arg Asn Asn Ile Val His Leu Asn Ile Ile Ala Lys Leu Ser Glu 
        835                 840                 845             


Leu Thr Ser Asn Ile Asp Lys Asp Ile Asn Ser Tyr Phe Asp Ile Tyr 
    850                 855                 860                 


His Tyr Cys Thr Gln Arg Val Met Phe Asp Tyr Cys Lys Lys Asn Asn 
865                 870                 875                 880 


Asn Val Val Leu Ala Lys Met Lys Asp Leu Ala His Ile Lys Ser Asp 
                885                 890                 895     


Cys Asp Glu Phe Ser Ser Lys His Thr Tyr Pro Phe Ser Ser Ala Val 
            900                 905                 910         


Leu Arg Phe Met Asn Leu Pro Phe Ala Tyr Asn Val Pro Arg Phe Lys 
        915                 920                 925             


Asn Leu Ser Tyr Lys Lys Phe Phe Asp Lys Gln 
    930                 935                 


<210>  3098
<211>  1011
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3098

Met Val Val Thr Tyr Leu Lys Trp Ile Ile Ile Leu Arg Glu Gly Thr 
1               5                   10                  15      


Met Lys Met Ala Lys Lys Lys Asn Ala Lys Gln Arg Arg Glu Glu Glu 
            20                  25                  30          


Lys Asn Arg Leu Lys Ala Lys Ile Glu Lys Phe Lys Ile Lys Tyr Ala 
        35                  40                  45              


Glu Gln Glu Thr Val Asp Lys Ile Thr Glu Glu Ile Ala Gln Ser Asp 
    50                  55                  60                  


Lys Ile Met Arg Thr Glu Ser Ile Leu Val Gln His Thr Lys Lys Ser 
65                  70                  75                  80  


Leu Ala Lys Ala Ser Gly Val Lys Ser Val Phe Ile Lys Asp Asp Glu 
                85                  90                  95      


Val Ile Met Thr Ser Phe Gly Arg Gly Asn Asp Ala Val Val Glu Lys 
            100                 105                 110         


Ile Ile Lys Asp Asn Asn Val Asp Glu Lys Asn Thr Lys Pro Ala Tyr 
        115                 120                 125             


Glu Ile Val Asp Ile Glu Lys Asn Gly Asp Leu Ile Lys Val Gln Ser 
    130                 135                 140                 


Arg Arg Cys Lys Asn Ile Glu Ser Ala Asn Thr Glu Leu Pro Pro Glu 
145                 150                 155                 160 


Lys Ile Gly Met Asp Leu Ile Arg Cys Lys Asp Lys Leu Glu Glu Ile 
                165                 170                 175     


Tyr Phe Gly Arg Thr Phe Asn Asp Asn Ile His Ile Gln Leu Ile Tyr 
            180                 185                 190         


Asn Ile Leu Asp Ile Glu Lys Ile Leu Ser Val Tyr Ile Asn Asn Ala 
        195                 200                 205             


Val Tyr Ala Leu Gly Asn Leu Glu Arg Lys Glu Asn Asp Lys Glu Lys 
    210                 215                 220                 


Asp Leu Val Gly Tyr Leu Ser Ala Arg Ala Gly Tyr Asn Lys Val Ile 
225                 230                 235                 240 


Asn Lys Ala Ile Asn Asp Glu Lys Ile Lys Asp Arg Ile Glu Asp Leu 
                245                 250                 255     


Lys Glu Phe Ile Glu Asn Gly Asn Arg Leu Gly Tyr Phe Gly Asp Ile 
            260                 265                 270         


Phe Phe Lys Lys Glu Glu Val Ser Lys Asn Gly Lys Lys Pro Lys Lys 
        275                 280                 285             


Val Glu Val Leu Lys Ser Glu Lys Glu Ile Phe Asp Ile Leu Ala Leu 
    290                 295                 300                 


Leu Gly Ser Leu Arg Gln Phe Cys Phe His Tyr Asp Glu Ala Val Phe 
305                 310                 315                 320 


Glu Asn Glu Asp Gly Val Ile Asp Lys Glu Tyr Asn Asp Asn Ser Trp 
                325                 330                 335     


Leu Tyr Asn Leu Glu Lys Leu Glu Pro Glu Phe Lys Asp Thr Leu Asp 
            340                 345                 350         


Tyr Phe Tyr Asn Arg Lys Ile Asn Asp Ile Asn Lys Gly Phe Ile Lys 
        355                 360                 365             


Thr Asn Gln Ile Asn Leu His Ile Ile Cys Asp Glu Leu Gly Leu Asn 
    370                 375                 380                 


Trp Asp Lys Glu Gln Val Val Gly Asp Tyr Tyr Asp Phe Leu Ile Ala 
385                 390                 395                 400 


Lys Lys Tyr Lys Asn Ile Gly Phe Ser Ile Lys Lys Ile Arg Glu His 
                405                 410                 415     


Met Phe Asp Ile Tyr Glu Ala Phe Asp Ile Lys Asp Lys Arg Phe Asp 
            420                 425                 430         


Ser Val Arg Ser Ile Met Tyr Lys Ile Ile Asp Phe Val Ile Tyr Tyr 
        435                 440                 445             


Ser Phe Ile His Tyr Lys Gln Asp Glu Val Asp Glu Ile Val Asn Tyr 
    450                 455                 460                 


Leu Arg Ser Thr Leu Ser Glu Glu Gln Lys Lys Glu Lys Tyr Ile Lys 
465                 470                 475                 480 


Leu Ala Gly Asn Ile Trp Ala Glu Tyr Lys Thr Gln Phe Asn Lys Leu 
                485                 490                 495     


Lys Asp Ile Leu Leu Ala Asn Ile Lys Glu Phe Ser Asp Ala Lys Glu 
            500                 505                 510         


Asp Asp Val Tyr Tyr Glu Glu Phe Lys Asn Phe Lys Phe Asn Glu Val 
        515                 520                 525             


Gly Lys Glu Lys Leu Gly Glu Asn Ala Glu Tyr Phe Cys Lys Leu Met 
    530                 535                 540                 


Tyr Leu Leu Thr Leu Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu 
545                 550                 555                 560 


Thr Thr Leu Ile Asn Lys Phe Asp Asn Ile Arg Ser Phe Val Glu Leu 
                565                 570                 575     


Met Lys Glu Glu Asn Ile Glu Cys Ile Phe Asp Lys Lys Phe Ala Phe 
            580                 585                 590         


Phe Asp Glu Ser Lys Asn Val Cys Ser Thr Leu Arg Glu Ile Asn Ser 
        595                 600                 605             


Phe Ala Arg Met Gln Lys Pro Leu Asn Asn Val Ser Val Lys Arg Glu 
    610                 615                 620                 


Met Tyr Lys Asp Ala Ile Lys Ile Leu Leu Lys Asp Thr Arg Ala Glu 
625                 630                 635                 640 


Glu Gln Asn Ile Asp Arg Ile Leu Asn Glu Tyr Ile Pro Ser Lys Glu 
                645                 650                 655     


Asp Lys Gly Ile Lys Lys Asp Phe Arg Asn Phe Ile Ile Lys Asn Ile 
            660                 665                 670         


Ile Lys Ser Asn Arg Phe Met Tyr Leu Val Lys Tyr Ser Asn Pro Thr 
        675                 680                 685             


Asp Val Arg Asn Leu Ala Ser Asn Arg Asn Val Val Lys Phe Val Leu 
    690                 695                 700                 


Asn Ala Ile Pro Asp Thr Gln Ile Asp Arg Tyr Tyr Lys Ser Cys Ile 
705                 710                 715                 720 


Gln His Tyr Ser Asn Glu Val Asp Lys Glu Thr Gln Ile Gln Glu Leu 
                725                 730                 735     


Thr Asp Ile Ile Thr Gly Ile Asp Tyr Leu Asp Phe Leu Asp Val Arg 
            740                 745                 750         


Gln Ser Tyr Arg Asn Glu Asp Lys Ser Lys Lys Gln Ala Val Val Thr 
        755                 760                 765             


Leu Tyr Leu Thr Ile Leu Tyr Ile Leu Thr Lys Asn Leu Val Asn Val 
    770                 775                 780                 


Asn Ser Arg Tyr Val Ile Ala Leu His Cys Leu Glu Arg Asp Ser Lys 
785                 790                 795                 800 


Leu Tyr Gly Tyr Thr Lys Leu Ser Lys Lys Asn Asn Lys Lys Leu Glu 
                805                 810                 815     


Lys Ile Lys Pro Pro Lys Tyr His Glu Leu Thr Lys Tyr Phe Ile Asp 
            820                 825                 830         


Asn Arg Tyr Phe Asp Arg Lys Lys Lys Asn Lys Lys Tyr Gly Glu Tyr 
        835                 840                 845             


Thr Ser Lys Lys Ile Ser Thr Tyr Ile Glu Thr Asn Met Lys Asn Phe 
    850                 855                 860                 


Ile Gly Cys Glu Gln Phe Arg Thr Pro Glu Arg Tyr Arg Asp Thr Gln 
865                 870                 875                 880 


Ile Asp Met Phe Val Lys Tyr Arg Asn Ser Ile Ala His Leu Asn Ala 
                885                 890                 895     


Val Arg Lys Ala Ser Lys Tyr Ile Asn Asp Ile Arg Gly Phe Asp Thr 
            900                 905                 910         


Tyr Phe Glu Leu Tyr His Tyr Ile Met Gln Arg Asp Leu Lys Asp Ile 
        915                 920                 925             


Leu Glu Lys Ile Ala Glu Gly Ala Ala Lys Glu Thr Glu Glu Gly Gln 
    930                 935                 940                 


Lys Gln Asp Glu Leu Leu Lys Thr Tyr Phe Asp Asn Leu Asp Lys Tyr 
945                 950                 955                 960 


Gly Thr Tyr Val Lys Asp Phe Val Lys Ala Leu Asn Ile Pro Phe Ala 
                965                 970                 975     


Tyr Asn Tyr Pro Arg Tyr Lys Asn Leu Ser Ile Asp Glu Leu Phe Asp 
            980                 985                 990         


Lys Asn Asn Thr Arg Lys Thr Ile  Lys Ile Gln Asp Lys  Lys Leu Glu 
        995                 1000                 1005             


Glu Arg  Thr 
    1010     


<210>  3099
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3099

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Val Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Glu Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asn Ser Ser Asn Ile Glu Leu Arg Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Gln Asn Thr Tyr Tyr Ile Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu Tyr Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Val Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Glu 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Pro Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Lys Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3100
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3100

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Gln Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Ser Val Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Gln Asn Thr Tyr Tyr Ile 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val 
            260                 265                 270         


Ser Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu 
    290                 295                 300                 


Tyr Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Val Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Ile Ala Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Leu Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Val Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Asn Arg Asp Glu Ser Pro Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asp Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  3101
<211>  924
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3101

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Lys Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Val 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys Arg Gly Asn Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Leu Glu Asn Glu Ser Asn 
        195                 200                 205             


Asn Asp Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe 
    210                 215                 220                 


Thr Asp Pro Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn Ile 
225                 230                 235                 240 


Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu 
                245                 250                 255     


Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val Ser 
            260                 265                 270         


Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln 
        275                 280                 285             


Ile Arg Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu Tyr 
    290                 295                 300                 


Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu 
305                 310                 315                 320 


Asp Tyr Leu Ile Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile 
                325                 330                 335     


Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly 
            340                 345                 350         


Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu 
        355                 360                 365             


Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys 
    370                 375                 380                 


Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser 
385                 390                 395                 400 


Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn 
                405                 410                 415     


Tyr Tyr Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu 
            420                 425                 430         


Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu 
        435                 440                 445             


Ala Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala 
    450                 455                 460                 


Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met 
465                 470                 475                 480 


Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp 
                485                 490                 495     


Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp 
            500                 505                 510         


Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp 
        515                 520                 525             


Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val 
    530                 535                 540                 


Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg 
545                 550                 555                 560 


Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys 
                565                 570                 575     


Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile 
            580                 585                 590         


Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu 
        595                 600                 605             


Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile 
    610                 615                 620                 


Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr 
625                 630                 635                 640 


Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val 
                645                 650                 655     


Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr 
            660                 665                 670         


Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys 
        675                 680                 685             


Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe 
    690                 695                 700                 


Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu 
705                 710                 715                 720 


Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu 
                725                 730                 735     


Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His 
            740                 745                 750         


Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu 
        755                 760                 765             


Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu 
    770                 775                 780                 


Cys Glu Leu Cys Asp Asn Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys 
785                 790                 795                 800 


Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala 
                805                 810                 815     


Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr 
            820                 825                 830         


Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp 
        835                 840                 845             


Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys 
    850                 855                 860                 


Arg Glu Asp Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp 
865                 870                 875                 880 


Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn 
                885                 890                 895     


Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu 
            900                 905                 910         


Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 


<210>  3102
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3102

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Asp Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Lys 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Leu Glu Asn Glu Ser Asn Asn Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe Thr Asp Pro 
    210                 215                 220                 


Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn Ile Lys Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu Tyr Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Ile Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Asp Asp Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Ile Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Arg Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3103
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3103

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Gln Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Ser Val Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Gln Asn Thr Tyr Tyr Ile 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val 
            260                 265                 270         


Ser Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu 
    290                 295                 300                 


Tyr Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Val Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Ile Ala Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Leu Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Asn Arg Asp Glu Ser Pro Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asp Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  3104
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3104

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Gly Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asp Tyr Asn 
                85                  90                  95      


Gln Thr Gln Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu Cys Gly 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Lys Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Ala Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe 
                325                 330                 335     


Ile Glu Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Phe Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Glu Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Cys Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Asp Arg Asp Lys Ser Ser Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asp Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asn Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  3105
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3105

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Ile Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Pro Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn His Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3106
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3106

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Glu Ser Ser Ser Asn Ile Glu Leu Cys Gly 
            100                 105                 110         


Val Thr Lys Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Gln Asn Thr Tyr Tyr Ile 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe 
    290                 295                 300                 


Asp Ile Tyr Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Tyr Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Val Pro Asp Met Asn Ser Ser Leu Glu Ala 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asp Leu Leu Lys Asn His Gly Tyr Thr Arg Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  3107
<211>  952
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3107

Met Gly Lys Lys Ile His Ala Arg Asp Leu Arg Glu Gln Arg Lys Thr 
1               5                   10                  15      


Asp Arg Thr Glu Lys Phe Ala Asp Gln Asn Lys Lys Arg Glu Ala Glu 
            20                  25                  30          


Arg Ala Val Gln Lys Lys Asp Ala Ala Val Ser Val Lys Ser Val Ser 
        35                  40                  45              


Ser Val Ser Ser Lys Lys Asp Asn Ala Thr Lys Ser Met Ala Lys Ala 
    50                  55                  60                  


Ala Gly Val Lys Ser Val Phe Ala Val Gly Asn Thr Val Tyr Met Thr 
65                  70                  75                  80  


Ser Phe Gly Arg Gly Asn Asp Ala Val Leu Glu Gln Lys Ile Val Asp 
                85                  90                  95      


Thr Ser His Glu Pro Leu Asn Ile Asp Asp Pro Ala Tyr Gln Leu Asn 
            100                 105                 110         


Val Val Thr Met Asn Gly Tyr Ser Val Thr Gly His Arg Gly Glu Thr 
        115                 120                 125             


Val Ser Ala Val Thr Asp Asn Pro Leu Arg Arg Phe Asn Gly Gly Lys 
    130                 135                 140                 


Lys Asp Glu Pro Glu Gln Ser Val Pro Thr Asp Met Leu Cys Leu Lys 
145                 150                 155                 160 


Pro Thr Leu Glu Lys Lys Phe Phe Gly Lys Glu Phe Asn Asp Asn Ile 
                165                 170                 175     


His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala 
            180                 185                 190         


Val Tyr Ser Thr Asn Ala Ile Tyr Ala Leu Asn Asn Met Ser Ala Asp 
        195                 200                 205             


Glu Asn Ile Glu Asn Ser Asp Phe Phe Met Lys Arg Thr Thr Asp Glu 
    210                 215                 220                 


Thr Phe Asp Asp Phe Glu Lys Lys Lys Glu Ser Thr Asn Ser Arg Glu 
225                 230                 235                 240 


Lys Ala Asp Phe Asp Ala Phe Glu Lys Phe Ile Gly Asn Tyr Arg Leu 
                245                 250                 255     


Ala Tyr Phe Ala Asp Ala Phe Tyr Val Asn Lys Lys Asn Pro Lys Gly 
            260                 265                 270         


Lys Ala Arg Asn Val Leu Arg Glu Asp Lys Glu Leu Tyr Ser Val Leu 
        275                 280                 285             


Thr Leu Ile Gly Lys Leu Arg His Trp Cys Val His Ser Glu Glu Gly 
    290                 295                 300                 


Arg Ala Glu Phe Trp Leu Tyr Lys Leu Asp Glu Leu Lys Asp Asp Phe 
305                 310                 315                 320 


Lys Asn Val Leu Asp Val Val Tyr Asn Arg Pro Val Glu Glu Ile Asn 
                325                 330                 335     


Asn Arg Phe Ile Glu Asn Asn Lys Val Asn Ile Gln Ile Leu Gly Ser 
            340                 345                 350         


Val Tyr Lys Asn Thr Asp Ile Ala Glu Leu Val Arg Ser Tyr Tyr Glu 
        355                 360                 365             


Phe Leu Ile Thr Lys Lys Tyr Lys Asn Met Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Ser Met Leu Glu Gly Lys Gly Tyr Ala Asp Lys Glu Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Asn Lys Leu Tyr Gln Met Thr Asp Phe Ile Leu Tyr 
                405                 410                 415     


Thr Gly Tyr Ile Asn Glu Asp Ser Asp Arg Ala Asp Asp Leu Val Asn 
            420                 425                 430         


Thr Leu Arg Ser Ser Leu Lys Glu Asp Asp Lys Thr Thr Val Tyr Cys 
        435                 440                 445             


Lys Glu Ala Asp Tyr Leu Trp Lys Lys Tyr Arg Glu Ser Ile Arg Glu 
    450                 455                 460                 


Val Ala Asp Ala Leu Asp Gly Asp Asn Ile Lys Lys Leu Ser Lys Ser 
465                 470                 475                 480 


Asn Ile Glu Ile Gln Glu Asp Lys Leu Arg Lys Cys Phe Ile Ser Tyr 
                485                 490                 495     


Ala Asp Ser Val Ser Glu Phe Thr Lys Leu Ile Tyr Leu Leu Thr Arg 
            500                 505                 510         


Phe Leu Ser Gly Lys Glu Ile Asn Asp Leu Val Thr Thr Leu Ile Asn 
        515                 520                 525             


Lys Phe Asp Asn Ile Arg Ser Phe Leu Glu Ile Met Asp Glu Leu Gly 
    530                 535                 540                 


Leu Asp Arg Thr Phe Thr Ala Glu Tyr Ser Phe Phe Glu Gly Ser Thr 
545                 550                 555                 560 


Lys Tyr Leu Ala Glu Leu Val Glu Leu Asn Ser Phe Val Lys Ser Cys 
                565                 570                 575     


Ser Phe Asp Ile Asn Ala Lys Arg Thr Met Tyr Arg Asp Ala Leu Asp 
            580                 585                 590         


Ile Leu Gly Ile Lys Ser Gly Lys Thr Glu Glu Asp Ile Glu Lys Met 
        595                 600                 605             


Ile Asp Asn Ile Leu Gln Ile Asp Ala Asn Gly Asp Lys Lys Leu Lys 
    610                 615                 620                 


Lys Asn Asn Gly Leu Arg Asn Phe Ile Ala Ser Asn Val Ile Asp Ser 
625                 630                 635                 640 


Asn Arg Phe Lys Tyr Leu Val Arg Tyr Gly Asn Pro Lys Lys Ile Arg 
                645                 650                 655     


Glu Thr Ala Lys Cys Lys Pro Ala Val Arg Phe Val Leu Asn Glu Ile 
            660                 665                 670         


Pro Asp Ala Gln Ile Glu Arg Tyr Tyr Glu Ala Cys Cys Pro Glu Asn 
        675                 680                 685             


Thr Ala Leu Cys Ser Ala Asn Lys Lys Arg Glu Lys Leu Ala Asp Met 
    690                 695                 700                 


Ile Ala Glu Ile Glu Phe Glu Asn Phe Ser Asp Ala Gly Asn Tyr Gln 
705                 710                 715                 720 


Lys Ala Asn Val Thr Ser Lys Thr His Glu Ala Glu Ile Lys Arg Lys 
                725                 730                 735     


Asn Gln Ser Ile Ile Arg Leu Tyr Leu Thr Val Met Tyr Ile Met Leu 
            740                 745                 750         


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Phe His Cys 
        755                 760                 765             


Val Glu Arg Asp Thr Lys Leu Tyr Ala Glu Ser Gly Leu Glu Val Gly 
    770                 775                 780                 


Asn Ile Glu Lys Asn Lys Thr Asn Leu Thr Met Ala Val Met Gly Val 
785                 790                 795                 800 


Lys Leu Glu Asn Gly Ile Ile Lys Thr Glu Phe Asp Lys Ser Leu Ala 
                805                 810                 815     


Glu Asn Ala Ala Asn Arg Tyr Leu Arg Asn Ala Arg Trp Tyr Lys Leu 
            820                 825                 830         


Ile Leu Asp Asn Leu Lys Met Ser Glu Arg Ala Val Val Asn Glu Phe 
        835                 840                 845             


Arg Asn Thr Val Cys His Leu Asn Ala Ile Arg Asn Ile Asn Ile Asn 
    850                 855                 860                 


Ile Lys Glu Ile Lys Glu Val Glu Asn Tyr Phe Ala Leu Tyr His Tyr 
865                 870                 875                 880 


Leu Ile Gln Lys His Leu Glu Asn Arg Phe Ala Asp Asn Gly Gly Ser 
                885                 890                 895     


Thr Gly Asp Tyr Ile Gly Lys Leu Glu Glu His Lys Thr Tyr Cys Lys 
            900                 905                 910         


Asp Phe Val Lys Ala Tyr Cys Thr Pro Phe Gly Tyr Asn Leu Val Arg 
        915                 920                 925             


Tyr Lys Asn Leu Thr Ile Asp Gly Leu Phe Asp Lys Asn Tyr Thr Gly 
    930                 935                 940                 


Lys Asp Asp Ser Asp Lys Gln Lys 
945                 950         


<210>  3108
<211>  954
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3108

Met Gly Lys Lys Ile His Ala Arg Asp Leu Arg Glu Gln Arg Lys Thr 
1               5                   10                  15      


Asp Arg Thr Glu Lys Phe Ala Asp Gln Asn Lys Lys Arg Glu Ala Glu 
            20                  25                  30          


Arg Ala Val Gln Lys Lys Asp Ala Ala Val Ser Val Lys Ser Val Ser 
        35                  40                  45              


Ser Val Ser Ser Lys Lys Asp Asn Val Thr Lys Ser Met Ala Lys Ala 
    50                  55                  60                  


Ala Gly Val Lys Ser Val Phe Ala Val Gly Asn Thr Val Tyr Met Thr 
65                  70                  75                  80  


Ser Phe Gly Arg Gly Asn Asp Ala Val Leu Glu Gln Lys Ile Val Asp 
                85                  90                  95      


Thr Ser His Glu Pro Leu Asn Ile Asp Asp Pro Ala Tyr Gln Leu Asn 
            100                 105                 110         


Val Val Thr Met Asn Gly Tyr Ser Val Thr Gly His Arg Gly Glu Thr 
        115                 120                 125             


Val Ser Ala Val Thr Asp Asn Pro Leu Arg Arg Phe Asn Gly Gly Lys 
    130                 135                 140                 


Lys Asp Glu Pro Glu Gln Ser Val Pro Thr Asp Met Leu Cys Leu Lys 
145                 150                 155                 160 


Pro Thr Leu Glu Lys Lys Phe Phe Gly Lys Glu Phe Asn Asp Asn Ile 
                165                 170                 175     


His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala 
            180                 185                 190         


Val Tyr Ser Thr Asn Ala Ile Tyr Ala Leu Asn Asn Met Ser Ala Asp 
        195                 200                 205             


Glu Asn Ile Glu Asn Ser Asp Phe Phe Met Lys Arg Thr Thr Asp Glu 
    210                 215                 220                 


Thr Phe Asp Asp Phe Glu Lys Lys Lys Glu Ser Thr Asn Ser Arg Glu 
225                 230                 235                 240 


Lys Ala Asp Phe Asp Ala Phe Glu Lys Phe Ile Gly Asn Tyr Arg Leu 
                245                 250                 255     


Ala Tyr Phe Ala Asp Ala Phe Tyr Val Asn Lys Lys Asn Pro Lys Gly 
            260                 265                 270         


Lys Ala Lys Asn Val Leu Arg Glu Asp Lys Glu Leu Tyr Ser Val Leu 
        275                 280                 285             


Thr Leu Ile Gly Lys Leu Arg His Trp Cys Val His Ser Glu Asp Gly 
    290                 295                 300                 


Arg Ala Glu Phe Trp Leu Tyr Lys Leu Asp Glu Leu Lys Asp Asp Phe 
305                 310                 315                 320 


Lys Asn Val Leu Asp Val Val Tyr Asn Arg Pro Val Glu Glu Ile Asn 
                325                 330                 335     


Asn Arg Phe Ile Glu Asn Asn Lys Val Asn Ile Gln Ile Leu Gly Ser 
            340                 345                 350         


Val Tyr Lys Asn Thr Asp Ile Ala Glu Leu Val Arg Ser Tyr Tyr Glu 
        355                 360                 365             


Phe Leu Ile Thr Lys Lys Tyr Lys Asn Met Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Ser Met Leu Glu Gly Lys Gly Tyr Ala Asp Lys Glu Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Asn Lys Leu Tyr Gln Met Thr Asp Phe Ile Leu Tyr 
                405                 410                 415     


Thr Gly Tyr Ile Asn Glu Asp Ser Asp Arg Ala Asp Asp Leu Val Asn 
            420                 425                 430         


Thr Leu Arg Ser Ser Leu Lys Glu Asp Asp Lys Thr Thr Val Tyr Cys 
        435                 440                 445             


Lys Glu Ala Asp Tyr Leu Trp Lys Lys Tyr Arg Glu Ser Ile Arg Glu 
    450                 455                 460                 


Val Ala Asp Ala Leu Asp Val Asp Asn Ile Lys Asn Leu Ser Gly Ser 
465                 470                 475                 480 


Asn Ile Glu Ile Arg Asp Asn Glu Leu Arg Lys Cys Phe Ile Ser Tyr 
                485                 490                 495     


Ala Asp Ser Val Ser Glu Phe Thr Lys Leu Ile Tyr Leu Leu Thr Arg 
            500                 505                 510         


Phe Leu Ser Gly Lys Glu Ile Asn Asp Leu Val Thr Thr Leu Ile Asn 
        515                 520                 525             


Lys Phe Asp Asn Ile Arg Ser Phe Leu Glu Ile Met Asp Glu Leu Gly 
    530                 535                 540                 


Leu Asp Arg Thr Phe Thr Ala Glu Tyr Ser Phe Phe Glu Gly Ser Thr 
545                 550                 555                 560 


Lys Tyr Leu Ala Glu Leu Val Glu Leu Asn Ser Phe Val Lys Ser Cys 
                565                 570                 575     


Ser Phe Asp Ile Asn Ala Lys Arg Thr Met Tyr Arg Asp Ala Leu Asp 
            580                 585                 590         


Ile Leu Gly Ile Lys Ser Gly Lys Thr Glu Glu Asp Ile Glu Lys Met 
        595                 600                 605             


Ile Asp Asn Ile Leu Gln Ile Asp Ala Asn Gly Asp Lys Lys Leu Lys 
    610                 615                 620                 


Lys Asn Asn Gly Leu Arg Asn Phe Ile Ala Ser Asn Val Ile Asp Ser 
625                 630                 635                 640 


Asn Arg Phe Lys Tyr Leu Val Arg Tyr Gly Asn Pro Lys Lys Ile Arg 
                645                 650                 655     


Glu Thr Ala Lys Cys Lys Pro Ala Val Arg Phe Val Leu Asn Glu Ile 
            660                 665                 670         


Pro Asp Ala Gln Ile Glu Arg Tyr Tyr Glu Ala Cys Cys Pro Lys Asn 
        675                 680                 685             


Thr Ala Leu Cys Ser Ala Asn Lys Arg Arg Glu Lys Leu Ala Asp Met 
    690                 695                 700                 


Ile Ala Glu Ile Lys Phe Glu Asn Phe Ser Asp Ala Gly Asn Tyr Gln 
705                 710                 715                 720 


Lys Ala Asn Val Thr Ser Arg Thr Ser Glu Ala Glu Ile Lys Arg Lys 
                725                 730                 735     


Asn Gln Ala Ile Ile Arg Leu Tyr Leu Thr Val Met Tyr Ile Met Leu 
            740                 745                 750         


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Phe His Cys 
        755                 760                 765             


Val Glu Arg Asp Thr Lys Leu Tyr Ala Glu Ser Gly Leu Glu Val Gly 
    770                 775                 780                 


Asn Ile Glu Lys Asn Lys Thr Asn Leu Thr Met Ala Val Met Gly Val 
785                 790                 795                 800 


Lys Leu Glu Asn Gly Thr Ile Lys Thr Glu Phe Asp Lys Ser Leu Ala 
                805                 810                 815     


Glu Asn Ala Ala Asn Arg Tyr Leu Arg Asn Ala Arg Trp Tyr Lys Leu 
            820                 825                 830         


Ile Leu Asp Asn Leu Lys Lys Ser Glu Arg Ala Val Val Thr Glu Phe 
        835                 840                 845             


Arg Asn Thr Val Cys His Leu Asn Ala Ile Arg Asn Ile Asn Ile Asn 
    850                 855                 860                 


Ile Lys Glu Ile Lys Glu Val Glu Asn Tyr Phe Ala Leu Tyr His Tyr 
865                 870                 875                 880 


Leu Ile Gln Lys His Leu Glu Asn Arg Phe Ala Asp Lys Lys Val Glu 
                885                 890                 895     


Arg Asp Thr Gly Asp Phe Ile Ser Lys Leu Glu Glu His Lys Thr Tyr 
            900                 905                 910         


Cys Lys Asp Phe Val Lys Ala Tyr Cys Thr Pro Phe Gly Tyr Asn Leu 
        915                 920                 925             


Val Arg Tyr Lys Asn Leu Thr Ile Asp Gly Leu Phe Asp Lys Asn Tyr 
    930                 935                 940                 


Pro Gly Lys Asp Asp Ser Asp Lys Gln Lys 
945                 950                 


<210>  3109
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3109

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Gly Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asp Tyr Asn 
                85                  90                  95      


Gln Thr Gln Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu Cys Gly 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Lys Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Ala Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe 
                325                 330                 335     


Ile Glu Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Phe Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Glu Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Cys Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Asp Arg Asp Lys Ser Ser Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asp Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asn Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  3110
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3110

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Gln Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Ser Val Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Gln Asn Thr Tyr Tyr Ile 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val 
            260                 265                 270         


Ser Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu 
    290                 295                 300                 


Tyr Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Val Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Ile Ala Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Leu Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Asn Arg Asp Glu Ser Pro Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asp Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  3111
<211>  939
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3111

Met Ala Lys Lys Lys Arg Ile Thr Ala Lys Glu Arg Lys Gln Asn His 
1               5                   10                  15      


Arg Glu Leu Leu Met Lys Lys Ala Asp Ser Asn Ala Glu Lys Glu Lys 
            20                  25                  30          


Ala Lys Lys Pro Val Val Glu Asn Lys Pro Asp Thr Ala Ile Ser Lys 
        35                  40                  45              


Asp Asn Thr Pro Lys Pro Asn Lys Glu Ile Lys Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Ala Gly Val Lys Trp Val Ile Lys Ala Asn Asp Asp Val Ala Tyr 
65                  70                  75                  80  


Ile Ser Ser Phe Gly Lys Gly Asn Asn Ser Val Leu Glu Lys Arg Ile 
                85                  90                  95      


Met Gly Asp Val Ser Ser Asn Val Asn Lys Asp Ser His Met Tyr Val 
            100                 105                 110         


Asn Pro Lys Tyr Thr Lys Lys Asn Tyr Glu Ile Lys Asn Gly Phe Ser 
        115                 120                 125             


Ser Gly Ser Ser Leu Val Thr Tyr Pro Asn Lys Pro Asp Lys Asn Ser 
    130                 135                 140                 


Gly Met Asp Ala Leu Cys Leu Lys Pro Tyr Phe Glu Lys Asp Phe Phe 
145                 150                 155                 160 


Gly His Ile Phe Thr Asp Asn Met His Ile Gln Ala Ile Tyr Asn Ile 
                165                 170                 175     


Phe Asp Ile Glu Lys Ile Leu Ala Lys His Ile Thr Asn Ile Ile Tyr 
            180                 185                 190         


Thr Val Asn Ser Phe Asp Arg Asn Tyr Asn Gln Ser Gly Asn Asp Thr 
        195                 200                 205             


Ile Gly Phe Gly Leu Asn Tyr Arg Val Pro Tyr Ser Glu Tyr Gly Gly 
    210                 215                 220                 


Gly Lys Asp Ser Asn Gly Glu Pro Lys Asn Lys Phe Lys Trp Glu Lys 
225                 230                 235                 240 


Arg Asp Asn Phe Ser Lys Phe Tyr Asn Glu Ser Lys Pro His Leu Gly 
                245                 250                 255     


Tyr Tyr Glu Asn Ile Phe Tyr Asp His Gly Glu Pro Ile Ser Glu Glu 
            260                 265                 270         


Lys Phe Tyr Asn Tyr Leu Asn Ile Leu Asn Phe Ile Arg Asn Asn Thr 
        275                 280                 285             


Phe His Tyr Lys Asp Asn Asp Ile Glu Leu Tyr Ser Glu Asn Tyr Ser 
    290                 295                 300                 


Glu Glu Tyr Val Phe Ile Asn Cys Leu Asn Lys Phe Val Lys Asn Lys 
305                 310                 315                 320 


Phe Lys Asn Val Asn Lys Asn Phe Ile Ser Asn Glu Lys Asn Asn Leu 
                325                 330                 335     


Tyr Ile Ile Leu Asn Ala Tyr Gly Lys Asp Thr Glu Asn Val Glu Val 
            340                 345                 350         


Val Lys Lys Tyr Ser Lys Glu Leu Tyr Lys Leu Ser Val Leu Lys Thr 
        355                 360                 365             


Asn Lys Asn Leu Gly Val Asn Val Lys Lys Leu Arg Glu Ser Ala Ile 
    370                 375                 380                 


Glu Tyr Gly Tyr Cys Pro Leu Pro Tyr Asp Lys Glu Lys Glu Val Ala 
385                 390                 395                 400 


Lys Leu Ser Ser Val Lys His Lys Leu Tyr Lys Thr Tyr Asp Phe Val 
                405                 410                 415     


Ile Thr His Tyr Leu Asn Ser Asn Asp Lys Ile Leu Leu Glu Ile Val 
            420                 425                 430         


Glu Ala Leu Arg Leu Ser Lys Asn Asp Asp Glu Lys Glu Asn Val Tyr 
        435                 440                 445             


Lys Lys Tyr Ala Glu Lys Leu Phe Lys Ala Asp Asp Val Ile Asn Pro 
    450                 455                 460                 


Ile Lys Ala Ile Ser Lys Leu Phe Val Glu Lys Gly Asn Lys Leu Phe 
465                 470                 475                 480 


Lys Glu Lys Ile Ile Ile Lys Lys Glu Tyr Ile Glu Asp Val Ser Ile 
                485                 490                 495     


Asp Lys Asn Ile Tyr Asp Phe Thr Lys Val Ile Phe Phe Met Thr Cys 
            500                 505                 510         


Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Asn Ile Ile Ser 
        515                 520                 525             


Lys Leu Gln Ile Ile Glu Asp His Asn Asn Val Ile Lys Phe Ile Ser 
    530                 535                 540                 


His Asn Lys Asp Ala Val Tyr Lys Asp Tyr Ser Asp Lys Tyr Ala Ile 
545                 550                 555                 560 


Phe Arg Asn Ala Gly Lys Ile Ala Thr Glu Leu Glu Ala Ile Lys Ser 
                565                 570                 575     


Ile Ala Arg Met Glu Asn Lys Ile Glu Asn Ala Ser Gln Glu Pro Leu 
            580                 585                 590         


Leu Asn Asp Ala Leu Leu Ser Leu Gly Val Ser Asp Asp Thr Lys Val 
        595                 600                 605             


Leu Glu Asn Thr Tyr Lys Lys Tyr Phe Asp Ser Lys Glu Lys Thr Asp 
    610                 615                 620                 


Lys Gln Ser Gln Lys Val Ser Thr Phe Leu Met Asn Asn Val Ile Asn 
625                 630                 635                 640 


Asn Asn Arg Phe Lys Tyr Val Ile Lys Tyr Ile Asn Pro Ala Asp Ile 
                645                 650                 655     


Asn Gly Leu Ala Lys Asn Arg Tyr Leu Val Lys Phe Val Leu Ser Lys 
            660                 665                 670         


Ile Pro Glu Glu Gln Ile Asp Ser Tyr Tyr Lys Leu Phe Ser Asn Glu 
        675                 680                 685             


Glu Glu Pro Gly Cys Glu Glu Lys Ile Lys Leu Leu Thr Lys Lys Ile 
    690                 695                 700                 


Ser Lys Leu Asn Phe Gln Thr Leu Phe Glu Asn Asn Lys Ile Pro Asn 
705                 710                 715                 720 


Val Glu Lys Glu Lys Lys Lys Ala Ile Ile Thr Leu Tyr Phe Thr Ile 
                725                 730                 735     


Val Tyr Ile Leu Val Lys Asn Leu Val Asn Ile Asn Gly Leu Tyr Thr 
            740                 745                 750         


Leu Ala Leu Tyr Phe Val Glu Arg Asp Gly Tyr Phe Tyr Lys Asp Ile 
        755                 760                 765             


Cys Gly Lys Lys Asp Lys Lys Lys Ser Tyr Asn Asp Val Asp Tyr Leu 
    770                 775                 780                 


Leu Leu Pro Glu Ile Phe Ser Gly Ser Lys Tyr Arg Glu Glu Thr Lys 
785                 790                 795                 800 


Asn Leu Lys Leu Pro Lys Glu Lys Asp Arg Asp Ile Met Lys Lys Tyr 
                805                 810                 815     


Leu Pro Asn Asp Lys Asp Arg Glu Lys Tyr Asn Lys Phe Phe Thr Ala 
            820                 825                 830         


Tyr Arg Asn Asn Ile Val His Leu Asn Ile Ile Ala Lys Leu Ser Glu 
        835                 840                 845             


Leu Thr Lys Asn Ile Asp Lys Asp Ile Asn Ser Tyr Phe Asp Ile Tyr 
    850                 855                 860                 


His Tyr Cys Thr Gln Arg Val Met Phe Asn Tyr Cys Lys Glu Lys Asn 
865                 870                 875                 880 


Asp Val Val Leu Ala Lys Met Lys Asp Leu Ala His Ile Lys Ser Asp 
                885                 890                 895     


Cys Asn Glu Phe Ser Ser Lys His Thr Tyr Pro Phe Ser Ser Ala Val 
            900                 905                 910         


Leu Arg Phe Met Asn Leu Pro Phe Ala Tyr Asn Val Pro Arg Phe Lys 
        915                 920                 925             


Asn Leu Ser Tyr Lys Lys Phe Phe Asp Lys Gln 
    930                 935                 


<210>  3112
<211>  977
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3112

Met Leu Leu Ser Glu Glu Leu Tyr Lys Trp Gly Lys Ala Gly Ser Thr 
1               5                   10                  15      


Met Ala Lys Lys Lys Lys Thr Ala Arg Gln Leu Arg Glu Glu Met Gln 
            20                  25                  30          


Gln Gln Arg Lys Gln Ala Ile Gln Lys Gln Gln Glu Gln Arg Gln Glu 
        35                  40                  45              


Lys Ala Ala Ala Ala Arg Glu Thr Ala Ala Pro Glu Gln Pro Ala Ala 
    50                  55                  60                  


Ala Pro Val Pro Lys Arg Gln Arg Lys Ser Leu Ala Lys Ala Ala Gly 
65                  70                  75                  80  


Leu Lys Ser Asn Phe Ile Leu Asp Pro Gln Arg Arg Thr Thr Val Met 
                85                  90                  95      


Thr Ala Phe Gly Gln Gly Ser Thr Ala Ile Leu Glu Lys Gln Ile Val 
            100                 105                 110         


Asp Arg Ala Ile Ser Asp Leu Gln Pro Val Gln Gln Phe Gln Val Glu 
        115                 120                 125             


Pro Ala Ser Ala Ala Lys Tyr Arg Leu Lys Asn Ser Arg Val Arg Phe 
    130                 135                 140                 


Pro Asn Val Thr Ala Asp Asp Pro Leu Tyr Arg Arg Lys Asp Gly Gly 
145                 150                 155                 160 


Phe Val Pro Gly Met Asp Ala Leu Arg Arg Lys Asn Val Leu Glu Gln 
                165                 170                 175     


Arg Phe Phe Gly Lys Ser Phe Ala Asp Asn Ile His Ile Gln Met Ile 
            180                 185                 190         


Tyr Ser Ile Leu Asp Ile His Lys Ile Leu Ala Ala Ala Ser Gly His 
        195                 200                 205             


Ile Val His Leu Leu Asn Ile Val Asn Gly Ser Lys Asp Arg Asp Phe 
    210                 215                 220                 


Ile Gly Met Leu Ala Ala His Val Leu Tyr Asn Glu Leu Asn Glu Glu 
225                 230                 235                 240 


Ala Lys Arg Ser Ile Ala Asp Phe Cys Lys Ser Pro Arg Leu Ile Tyr 
                245                 250                 255     


Tyr Ser Ala Ala Phe Tyr Glu Thr Leu Asp Asn Gly Lys Ser Glu Arg 
            260                 265                 270         


Arg Ser Asn Glu Asp Ile Phe Asn Ile Leu Ala Leu Met Thr Cys Leu 
        275                 280                 285             


Arg Asn Phe Ser Ser His His Ser Ile Ala Ile Lys Val Lys Asp Tyr 
    290                 295                 300                 


Ser Ala Ala Gly Leu Tyr Asn Leu Arg Arg Leu Gly Pro Asp Met Lys 
305                 310                 315                 320 


Lys Met Leu Asp Thr Phe Tyr Thr Glu Ala Phe Ile Gln Leu Asn Gln 
                325                 330                 335     


Ser Phe Gln Asp His Asn Thr Thr Asn Leu Thr Cys Leu Phe Asp Ile 
            340                 345                 350         


Leu Asn Ile Ser Asp Ser Ala Arg Gln Lys Gln Leu Ala Glu Glu Phe 
        355                 360                 365             


Tyr Arg Tyr Val Val Phe Lys Glu Gln Lys Asn Leu Gly Phe Ser Val 
    370                 375                 380                 


Arg Lys Leu Arg Glu Glu Met Leu Leu Leu Pro Asp Ala Ala Val Ile 
385                 390                 395                 400 


Ala Asp Lys Arg Tyr Asp Thr Cys Arg Ser Lys Leu Tyr Asn Leu Met 
                405                 410                 415     


Asp Phe Leu Ile Leu Arg Val Tyr Arg Thr Gly Arg Ala Asp Arg Cys 
            420                 425                 430         


Asp Lys Leu Pro Glu Ala Leu Arg Ala Ala Leu Thr Asp Glu Glu Lys 
        435                 440                 445             


Ala Val Val Tyr His Lys Glu Ala Leu Ser Leu Trp Asn Glu Met Arg 
    450                 455                 460                 


Thr Leu Ile Leu Asp Gly Leu Leu Pro Gln Met Thr Pro Glu Asn Leu 
465                 470                 475                 480 


Ser Arg Leu Ser Gly Gln Lys Arg Lys Gly Glu Leu Ser Leu Asp Asp 
                485                 490                 495     


Ala Met Leu Lys Glu Cys Leu Tyr Glu Pro Gly Pro Val Pro Glu Asp 
            500                 505                 510         


Ala Ala Pro Glu Glu Ala Asn Ala Glu Tyr Phe Cys Arg Met Ile Tyr 
        515                 520                 525             


Leu Ala Thr Leu Phe Met Asp Gly Lys Glu Ile Asn Thr Leu Leu Thr 
    530                 535                 540                 


Thr Leu Ile Ser Lys Phe Glu Asn Ile Ala Ala Phe Leu Gln Thr Met 
545                 550                 555                 560 


Glu Gln Leu Asn Ile Glu Ala Glu Leu Gly Pro Glu Tyr Ala Met Phe 
                565                 570                 575     


Thr Arg Ser Arg Ala Val Ala Glu Gln Leu Arg Val Ile Asn Ser Phe 
            580                 585                 590         


Ala Leu Met Lys Lys Pro Gln Val Asn Ala Lys Gln Gln Leu Tyr Arg 
        595                 600                 605             


Ala Ala Val Thr Leu Leu Gly Thr Glu Asp Pro Asp Gly Val Thr Asp 
    610                 615                 620                 


Glu Met Leu Cys Ile Asp Pro Val Thr Gly Lys Met Leu Pro Pro Asn 
625                 630                 635                 640 


Gln Arg His His Gly Asp Thr Gly Leu Arg Asn Phe Ile Ala Asn Asn 
                645                 650                 655     


Val Val Glu Ser Arg Arg Phe Gln Tyr Leu Ile Arg Tyr Ser Asp Pro 
            660                 665                 670         


Ala Gln Leu His Gln Leu Ala Ser Asn Lys Lys Leu Val Arg Phe Val 
        675                 680                 685             


Leu Ser Ser Ile Pro Asp Thr Gln Ile Asn Arg Tyr Tyr Glu Thr Cys 
    690                 695                 700                 


Gly Gln Thr Arg Leu Ala Gly Arg Ala Ala Lys Val Glu Phe Leu Thr 
705                 710                 715                 720 


Asp Met Ile Ala Ala Ile Arg Phe Asp Gln Phe Arg Asp Val Asn Gln 
                725                 730                 735     


Lys Glu Arg Gly Ala Asn Thr Gln Lys Glu Arg Tyr Lys Ala Met Leu 
            740                 745                 750         


Gly Leu Tyr Gln Thr Val Leu Tyr Leu Ala Val Lys Asn Leu Val Asn 
        755                 760                 765             


Ile Asn Ala Arg Tyr Val Met Ala Phe His Cys Val Glu Arg Asp Met 
    770                 775                 780                 


Phe Leu Tyr Asp Gly Glu Leu Thr Asp Pro Lys Gly Glu Ser Val Ser 
785                 790                 795                 800 


Ala Phe Leu Ala Val Asn Gly Lys Lys Gly Val Gln Pro Gln Tyr Leu 
                805                 810                 815     


Leu Leu Thr Gln Leu Phe Ile Arg Arg Asp Tyr Leu Lys Arg Ser Ala 
            820                 825                 830         


Cys Glu Gln Ile Gln His Asn Met Glu Asn Ile Ser Asp Arg Leu Leu 
        835                 840                 845             


Arg Glu Tyr Arg Asn Ala Val Ala His Leu Asn Val Ile Ala His Leu 
    850                 855                 860                 


Ala Asp Tyr Ser Ala Asp Met Arg Glu Ile Thr Ser Tyr Tyr Gly Leu 
865                 870                 875                 880 


Tyr His Tyr Leu Met Gln Arg His Leu Phe Lys Arg His Ala Trp Gln 
                885                 890                 895     


Ile Arg Gln Pro Glu Arg Pro Thr Glu Glu Glu Gln Lys Leu Ile Glu 
            900                 905                 910         


Gln Glu Gln Lys Gln Leu Ala Trp Glu Lys Ala Leu Phe Asp Lys Thr 
        915                 920                 925             


Leu Gln Tyr His Ser Tyr Asn Lys Asp Leu Val Lys Ala Leu Asn Ala 
    930                 935                 940                 


Pro Phe Gly Tyr Asn Leu Ala Arg Tyr Lys Asn Leu Ser Ile Glu Pro 
945                 950                 955                 960 


Leu Phe Ser Lys Glu Ala Ala Pro Ala Ala Glu Ile Lys Ala Thr His 
                965                 970                 975     


Ala 
    


<210>  3113
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3113

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Gly Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asp Tyr Asn 
                85                  90                  95      


Gln Thr Gln Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu Cys Gly 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Lys Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Ala Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe 
                325                 330                 335     


Ile Glu Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Phe Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Glu Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Cys Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Asp Arg Asp Lys Ser Ser Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asp Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asn Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  3114
<211>  921
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3114

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Thr 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asn Asn Ile Tyr Pro Glu Tyr Arg Asp Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Ile Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp 
    370                 375                 380                 


Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Tyr Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Lys Ile Thr Asp Asp Arg Ile Arg Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn Lys 
785                 790                 795                 800 


Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser 
                805                 810                 815     


Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg 
            820                 825                 830         


Glu Leu Lys Lys Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe 
        835                 840                 845             


Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp 
    850                 855                 860                 


Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys 
865                 870                 875                 880 


Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe 
                885                 890                 895     


Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe 
            900                 905                 910         


Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920     


<210>  3115
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3115

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asp Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Gly Asp Glu Ser His Asp Asp 
        195                 200                 205             


Ile Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe Thr Asp 
    210                 215                 220                 


Pro Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Ala Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu Tyr Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Ile Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Met Gly Ala Lys Arg Arg 
        675                 680                 685             


Glu Leu Ala Lys Met Ile Lys Ser Ile Ser Phe Glu Asp Phe Lys Asp 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Asn Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Asn Lys Tyr Ile Lys Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Asn Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3116
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3116

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Ser Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu His Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Pro Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Thr Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ser 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ser Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Lys Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Met Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp Asp Thr 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Ser Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  3117
<211>  924
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3117

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Lys Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Val 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys Arg Gly Asn Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Leu Glu Asn Glu Ser Asn 
        195                 200                 205             


Asn Asp Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe 
    210                 215                 220                 


Thr Asp Pro Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn Ile 
225                 230                 235                 240 


Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu 
                245                 250                 255     


Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val Ser 
            260                 265                 270         


Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln 
        275                 280                 285             


Ile Arg Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu Tyr 
    290                 295                 300                 


Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu 
305                 310                 315                 320 


Asp Tyr Leu Ile Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile 
                325                 330                 335     


Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly 
            340                 345                 350         


Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu 
        355                 360                 365             


Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys 
    370                 375                 380                 


Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser 
385                 390                 395                 400 


Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn 
                405                 410                 415     


Tyr Tyr Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu 
            420                 425                 430         


Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu 
        435                 440                 445             


Ala Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala 
    450                 455                 460                 


Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met 
465                 470                 475                 480 


Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp 
                485                 490                 495     


Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp 
            500                 505                 510         


Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp 
        515                 520                 525             


Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val 
    530                 535                 540                 


Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg 
545                 550                 555                 560 


Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys 
                565                 570                 575     


Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile 
            580                 585                 590         


Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu 
        595                 600                 605             


Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile 
    610                 615                 620                 


Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr 
625                 630                 635                 640 


Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val 
                645                 650                 655     


Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr 
            660                 665                 670         


Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys 
        675                 680                 685             


Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe 
    690                 695                 700                 


Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu 
705                 710                 715                 720 


Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu 
                725                 730                 735     


Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His 
            740                 745                 750         


Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu 
        755                 760                 765             


Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu 
    770                 775                 780                 


Cys Glu Leu Cys Asp Asn Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys 
785                 790                 795                 800 


Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala 
                805                 810                 815     


Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr 
            820                 825                 830         


Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp 
        835                 840                 845             


Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys 
    850                 855                 860                 


Arg Glu Asp Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp 
865                 870                 875                 880 


Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn 
                885                 890                 895     


Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu 
            900                 905                 910         


Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 


<210>  3118
<211>  939
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3118

Met Ala Lys Lys Lys Arg Ile Thr Ala Lys Glu Arg Lys Gln Asn His 
1               5                   10                  15      


Arg Glu Leu Leu Met Lys Lys Ala Asp Ser Asn Ala Glu Lys Glu Lys 
            20                  25                  30          


Ala Lys Lys Pro Val Val Glu Asn Lys Pro Asp Thr Ala Ile Ser Lys 
        35                  40                  45              


Asp Asn Thr Pro Lys Pro Asn Lys Glu Ile Lys Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Ala Gly Val Lys Trp Val Ile Lys Ala Asn Asp Asp Val Ala Tyr 
65                  70                  75                  80  


Ile Ser Ser Phe Gly Lys Gly Asn Asn Ser Val Leu Glu Lys Arg Ile 
                85                  90                  95      


Met Gly Asp Val Ser Ser Asn Val Asn Lys Asp Ser His Met Tyr Val 
            100                 105                 110         


Asn Pro Lys Tyr Thr Lys Lys Asn Tyr Glu Ile Lys Asn Gly Phe Ser 
        115                 120                 125             


Ser Gly Ser Ser Leu Val Thr Tyr Pro Asn Lys Pro Asp Lys Asn Ser 
    130                 135                 140                 


Gly Met Asp Ala Leu Cys Leu Lys Pro Tyr Phe Glu Lys Asp Phe Phe 
145                 150                 155                 160 


Gly His Ile Phe Thr Asp Asn Met His Ile Gln Ala Ile Tyr Asn Ile 
                165                 170                 175     


Phe Asp Ile Glu Lys Ile Leu Ala Lys His Ile Thr Asn Ile Ile Tyr 
            180                 185                 190         


Thr Val Asn Ser Phe Asp Arg Asn Tyr Asn Gln Ser Gly Asn Asp Thr 
        195                 200                 205             


Ile Gly Phe Gly Leu Asn Tyr Arg Val Pro Tyr Ser Glu Tyr Gly Gly 
    210                 215                 220                 


Gly Lys Asp Ser Asn Gly Glu Pro Lys Asn Lys Phe Lys Trp Glu Lys 
225                 230                 235                 240 


Arg Asp Asn Phe Ser Lys Phe Tyr Asn Glu Ser Lys Pro His Leu Gly 
                245                 250                 255     


Tyr Tyr Glu Asn Ile Phe Tyr Asp His Gly Glu Pro Ile Ser Glu Glu 
            260                 265                 270         


Lys Phe Tyr Asn Tyr Leu Asn Ile Leu Asn Phe Ile Arg Asn Asn Thr 
        275                 280                 285             


Phe His Tyr Lys Asp Asn Asp Ile Glu Leu Tyr Ser Glu Asn Tyr Ser 
    290                 295                 300                 


Glu Glu Tyr Val Phe Ile Asn Cys Leu Asn Lys Phe Val Lys Asn Lys 
305                 310                 315                 320 


Phe Lys Asn Val Asn Lys Asn Phe Ile Ser Asn Glu Lys Asn Asn Leu 
                325                 330                 335     


Tyr Ile Ile Leu Asn Ala Tyr Gly Lys Asp Thr Glu Asn Val Glu Val 
            340                 345                 350         


Val Lys Lys Tyr Ser Lys Glu Leu Tyr Lys Leu Ser Val Leu Lys Thr 
        355                 360                 365             


Asn Lys Asn Leu Gly Val Asn Val Lys Lys Leu Arg Glu Ser Ala Ile 
    370                 375                 380                 


Glu Tyr Gly Tyr Cys Pro Leu Pro Tyr Asp Lys Glu Lys Glu Val Ala 
385                 390                 395                 400 


Lys Leu Ser Ser Val Lys His Lys Leu Tyr Lys Thr Tyr Asp Phe Val 
                405                 410                 415     


Ile Thr His Tyr Leu Asn Ser Asn Asp Lys Ile Leu Leu Glu Ile Val 
            420                 425                 430         


Glu Ala Leu Arg Leu Ser Lys Asn Asp Asp Glu Lys Glu Asn Val Tyr 
        435                 440                 445             


Lys Lys Tyr Ala Glu Lys Leu Phe Lys Ala Asp Asp Val Ile Asn Pro 
    450                 455                 460                 


Ile Lys Ala Ile Ser Lys Leu Phe Val Glu Lys Gly Asn Lys Leu Phe 
465                 470                 475                 480 


Lys Glu Lys Ile Ile Ile Lys Lys Glu Tyr Ile Glu Asp Val Ser Ile 
                485                 490                 495     


Asp Lys Asn Ile Tyr Asp Phe Thr Lys Val Ile Phe Phe Met Thr Cys 
            500                 505                 510         


Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Asn Ile Ile Ser 
        515                 520                 525             


Lys Leu Gln Ile Ile Glu Asp His Asn Asn Val Ile Lys Phe Ile Ser 
    530                 535                 540                 


His Asn Lys Asp Ala Val Tyr Lys Asp Tyr Ser Asp Lys Tyr Ala Ile 
545                 550                 555                 560 


Phe Arg Asn Ala Gly Lys Ile Ala Thr Glu Leu Glu Ala Ile Lys Ser 
                565                 570                 575     


Ile Ala Arg Met Glu Asn Lys Ile Glu Asn Ala Ser Gln Glu Pro Leu 
            580                 585                 590         


Leu Asn Asp Ala Leu Leu Ser Leu Gly Val Ser Asp Asp Thr Lys Val 
        595                 600                 605             


Leu Glu Asn Thr Tyr Lys Lys Tyr Phe Asp Ser Lys Glu Lys Thr Asp 
    610                 615                 620                 


Lys Gln Ser Gln Lys Val Ser Thr Phe Leu Met Asn Asn Val Ile Asn 
625                 630                 635                 640 


Asn Asn Arg Phe Lys Tyr Val Ile Lys Tyr Ile Asn Pro Ala Asp Ile 
                645                 650                 655     


Asn Gly Leu Ala Lys Asn Arg Tyr Leu Val Lys Phe Val Leu Ser Lys 
            660                 665                 670         


Ile Pro Glu Glu Gln Ile Asp Ser Tyr Tyr Lys Leu Phe Ser Asn Glu 
        675                 680                 685             


Glu Glu Pro Gly Cys Glu Glu Lys Ile Lys Leu Leu Thr Lys Lys Ile 
    690                 695                 700                 


Ser Lys Leu Asn Phe Gln Thr Leu Phe Glu Asn Asn Lys Ile Pro Asn 
705                 710                 715                 720 


Val Glu Lys Glu Lys Lys Lys Ala Ile Ile Thr Leu Tyr Phe Thr Ile 
                725                 730                 735     


Val Tyr Ile Leu Val Lys Asn Leu Val Asn Ile Asn Gly Leu Tyr Thr 
            740                 745                 750         


Leu Ala Leu Tyr Phe Val Glu Arg Asp Gly Tyr Phe Tyr Lys Asp Ile 
        755                 760                 765             


Cys Gly Lys Lys Asp Lys Lys Lys Ser Tyr Asn Asp Val Asp Tyr Leu 
    770                 775                 780                 


Leu Leu Pro Glu Ile Phe Ser Gly Ser Lys Tyr Arg Glu Glu Thr Lys 
785                 790                 795                 800 


Asn Leu Lys Leu Pro Lys Glu Lys Asp Arg Asp Ile Met Lys Lys Tyr 
                805                 810                 815     


Leu Pro Asn Asp Lys Asp Arg Glu Lys Tyr Asn Lys Phe Phe Thr Ala 
            820                 825                 830         


Tyr Arg Asn Asn Ile Val His Leu Asn Ile Ile Ala Lys Leu Ser Glu 
        835                 840                 845             


Leu Thr Lys Asn Ile Asp Lys Asp Ile Asn Ser Tyr Phe Asp Ile Tyr 
    850                 855                 860                 


His Tyr Cys Thr Gln Arg Val Met Phe Asn Tyr Cys Lys Glu Lys Asn 
865                 870                 875                 880 


Asp Val Val Leu Ala Lys Met Lys Asp Leu Ala His Ile Lys Ser Asp 
                885                 890                 895     


Cys Asn Glu Phe Ser Ser Lys His Thr Tyr Pro Phe Ser Ser Ala Val 
            900                 905                 910         


Leu Arg Phe Met Asn Leu Pro Phe Ala Tyr Asn Val Pro Arg Phe Lys 
        915                 920                 925             


Asn Leu Ser Tyr Lys Lys Phe Phe Asp Lys Gln 
    930                 935                 


<210>  3119
<211>  924
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3119

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Phe Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Leu Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Leu Ser Glu His Ser Glu Tyr Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asp Asn Ser Lys Lys Val Tyr Arg Glu Cys Arg Glu Thr Leu 
305                 310                 315                 320 


Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile 
                325                 330                 335     


Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly 
            340                 345                 350         


Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu 
        355                 360                 365             


Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys 
    370                 375                 380                 


Ile Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser 
385                 390                 395                 400 


Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn 
                405                 410                 415     


Tyr Tyr Arg Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu 
            420                 425                 430         


Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu 
        435                 440                 445             


Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala 
    450                 455                 460                 


Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met 
465                 470                 475                 480 


Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp 
                485                 490                 495     


Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp 
            500                 505                 510         


Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp 
        515                 520                 525             


Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val 
    530                 535                 540                 


Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg 
545                 550                 555                 560 


Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys 
                565                 570                 575     


Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile 
            580                 585                 590         


Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu 
        595                 600                 605             


Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile 
    610                 615                 620                 


Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr 
625                 630                 635                 640 


Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val 
                645                 650                 655     


Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr 
            660                 665                 670         


Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys 
        675                 680                 685             


Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe 
    690                 695                 700                 


Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu 
705                 710                 715                 720 


Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu 
                725                 730                 735     


Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His 
            740                 745                 750         


Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu 
        755                 760                 765             


Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu 
    770                 775                 780                 


Cys Glu Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys 
785                 790                 795                 800 


Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala 
                805                 810                 815     


Asp Ser Asn Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr 
            820                 825                 830         


Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp 
        835                 840                 845             


Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys 
    850                 855                 860                 


Arg Glu Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp 
865                 870                 875                 880 


Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn 
                885                 890                 895     


Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu 
            900                 905                 910         


Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 


<210>  3120
<211>  921
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3120

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Gly Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Asn Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu Tyr Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Val Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp 
    370                 375                 380                 


Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Ile Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Glu Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn Arg 
785                 790                 795                 800 


Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser 
                805                 810                 815     


Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg 
            820                 825                 830         


Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe 
        835                 840                 845             


Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp 
    850                 855                 860                 


Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys 
865                 870                 875                 880 


Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe 
                885                 890                 895     


Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe 
            900                 905                 910         


Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920     


<210>  3121
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3121

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Lys Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asn Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Met Lys 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Asp Glu Ser His Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe Thr Asp 
    210                 215                 220                 


Pro Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Asn Ala Leu Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Ile Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3122
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3122

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Lys Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asn Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Asp Glu Ser His Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe Thr Asp 
    210                 215                 220                 


Pro Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Asn Ala Leu Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Pro Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp Asp Ile 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  3123
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3123

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Lys Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asn Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Met Lys 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Asp Glu Ser His Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe Thr Asp 
    210                 215                 220                 


Pro Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Asn Ala Leu Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Ile Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3124
<211>  924
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3124

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Phe Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Leu Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Leu Ser Glu His Ser Glu Tyr Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asp Asn Ser Lys Lys Val Tyr Arg Glu Cys Arg Glu Thr Leu 
305                 310                 315                 320 


Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile 
                325                 330                 335     


Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly 
            340                 345                 350         


Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu 
        355                 360                 365             


Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys 
    370                 375                 380                 


Ile Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser 
385                 390                 395                 400 


Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn 
                405                 410                 415     


Tyr Tyr Arg Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu 
            420                 425                 430         


Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu 
        435                 440                 445             


Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala 
    450                 455                 460                 


Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met 
465                 470                 475                 480 


Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp 
                485                 490                 495     


Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp 
            500                 505                 510         


Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp 
        515                 520                 525             


Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val 
    530                 535                 540                 


Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg 
545                 550                 555                 560 


Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys 
                565                 570                 575     


Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile 
            580                 585                 590         


Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu 
        595                 600                 605             


Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile 
    610                 615                 620                 


Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr 
625                 630                 635                 640 


Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val 
                645                 650                 655     


Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr 
            660                 665                 670         


Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys 
        675                 680                 685             


Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe 
    690                 695                 700                 


Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu 
705                 710                 715                 720 


Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu 
                725                 730                 735     


Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His 
            740                 745                 750         


Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu 
        755                 760                 765             


Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu 
    770                 775                 780                 


Cys Glu Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys 
785                 790                 795                 800 


Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala 
                805                 810                 815     


Asp Ser Asn Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr 
            820                 825                 830         


Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp 
        835                 840                 845             


Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys 
    850                 855                 860                 


Arg Glu Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp 
865                 870                 875                 880 


Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn 
                885                 890                 895     


Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu 
            900                 905                 910         


Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 


<210>  3125
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3125

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys Arg Gly Asn Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Lys Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Ala Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Glu Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Ile Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Ala Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Tyr Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Glu Arg Asp Lys Ser Pro Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Ile Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  3126
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3126

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asn Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Asp Glu Ser His Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe Thr Asp 
    210                 215                 220                 


Pro Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Asn Ala Leu Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Ile Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Leu Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ser Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Met Gly Ala Lys Arg Arg 
        675                 680                 685             


Glu Leu Ala Lys Met Ile Lys Ser Ile Ser Phe Glu Asp Phe Lys Asp 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Asn Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Asn Lys Tyr Ile Lys Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Asn Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3127
<211>  921
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3127

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Asp Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Lys 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Leu Glu Asn Glu Ser Asn Asn Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe Thr Asp Pro 
    210                 215                 220                 


Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn Ile Lys Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu Tyr Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Ile Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp 
    370                 375                 380                 


Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr His Arg 
                405                 410                 415     


Lys Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Glu Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Thr Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Glu Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Met Gly Ala Lys Arg Arg Glu 
        675                 680                 685             


Leu Ala Lys Met Ile Lys Ser Ile Ser Phe Glu Asn Phe Lys Asp Val 
    690                 695                 700                 


Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn Lys 
785                 790                 795                 800 


Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Asn 
                805                 810                 815     


Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg 
            820                 825                 830         


Glu Leu Lys Glu Tyr Ile Gly Asp Ile Tyr Ala Val Asp Ser Tyr Phe 
        835                 840                 845             


Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn 
    850                 855                 860                 


Asp Thr Glu Gln Ala Glu Lys Ile Lys Tyr Glu Asp Asp Leu Phe Lys 
865                 870                 875                 880 


Asn His Gly Tyr Thr Arg Asp Phe Val Lys Ala Leu Asn Ser Pro Phe 
                885                 890                 895     


Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Lys Gln Met Phe 
            900                 905                 910         


Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920     


<210>  3128
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3128

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Ser Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu His Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Pro Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Thr Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ser 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ser Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Lys Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Met Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp Asp Thr 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Ser Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  3129
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3129

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Lys Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Ala Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Pro Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Ile Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ile Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp Asp Thr 
    850                 855                 860                 


Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  3130
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3130

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Ile Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Ile Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Asn Arg Val Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu His Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Ile Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Glu 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Pro Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp Asp Ile 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  3131
<211>  954
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3131

Met Gly Lys Lys Ile His Ala Arg Asp Leu Arg Glu Gln Arg Lys Thr 
1               5                   10                  15      


Asp Arg Thr Val Lys Phe Ala Asp Gln Asn Lys Lys Arg Glu Ala Glu 
            20                  25                  30          


Arg Ala Val Gln Lys Lys Asp Ala Ala Val Ser Val Lys Ser Val Pro 
        35                  40                  45              


Ser Val Ser Ser Lys Lys Asp Asn Val Thr Lys Ser Met Ala Lys Ala 
    50                  55                  60                  


Ala Gly Val Lys Ser Val Phe Ala Val Gly Asn Thr Val Tyr Met Thr 
65                  70                  75                  80  


Ser Phe Gly Arg Gly Asn Asp Ala Val Leu Glu Gln Lys Ile Val Asp 
                85                  90                  95      


Thr Ser His Glu Pro Leu Asn Ile Asp Asp Pro Ala Tyr Gln Leu Asn 
            100                 105                 110         


Val Val Thr Met Asn Gly Tyr Ser Val Ile Gly His Arg Gly Glu Thr 
        115                 120                 125             


Val Ser Ala Val Thr Asp Asn Pro Leu Arg Arg Phe Asn Gly Gly Lys 
    130                 135                 140                 


Lys Asp Glu Pro Glu Gln Ser Val Pro Thr Asp Met Leu Cys Leu Lys 
145                 150                 155                 160 


Pro Thr Leu Glu Lys Lys Phe Phe Gly Lys Glu Phe Asp Asp Asn Ile 
                165                 170                 175     


His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala 
            180                 185                 190         


Val Tyr Ser Thr Asn Ala Ile Tyr Ala Leu Asn Asn Met Ser Ala Asp 
        195                 200                 205             


Glu Asn Ile Glu Asn Ser Asp Phe Phe Met Lys Arg Thr Thr Asp Glu 
    210                 215                 220                 


Thr Phe Asp Asp Phe Glu Lys Lys Lys Glu Ser Thr Asn Ser Arg Glu 
225                 230                 235                 240 


Lys Ala Asp Phe Asp Ala Phe Glu Lys Phe Ile Gly Asn Tyr Arg Leu 
                245                 250                 255     


Ala Tyr Phe Ala Asp Ala Phe Tyr Val Asn Lys Lys Asn Pro Lys Gly 
            260                 265                 270         


Lys Ala Lys Asn Val Leu Arg Glu Asp Lys Glu Leu Tyr Ser Val Leu 
        275                 280                 285             


Thr Leu Ile Gly Lys Leu Arg His Trp Cys Val His Ser Glu Glu Gly 
    290                 295                 300                 


Arg Ala Glu Phe Trp Leu Tyr Lys Leu Asp Glu Leu Lys Asp Asp Phe 
305                 310                 315                 320 


Lys Asn Val Leu Asp Val Val Tyr Asn Arg Pro Val Glu Glu Ile Asn 
                325                 330                 335     


Asn Arg Phe Ile Glu Asn Asn Lys Val Asn Ile Gln Ile Leu Gly Ser 
            340                 345                 350         


Val Tyr Lys Asn Thr Asp Ile Ala Glu Leu Val Arg Ser Tyr Tyr Glu 
        355                 360                 365             


Phe Leu Ile Thr Lys Lys Tyr Lys Asn Met Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Ser Met Leu Glu Gly Lys Gly Tyr Ala Asp Lys Glu Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Asn Lys Leu Tyr Gln Met Thr Asp Phe Ile Leu Tyr 
                405                 410                 415     


Thr Gly Tyr Ile Asn Glu Asp Ser Asp Arg Ala Asp Asp Leu Val Asn 
            420                 425                 430         


Thr Leu Arg Ser Ser Leu Lys Glu Asp Asp Lys Thr Thr Val Tyr Cys 
        435                 440                 445             


Lys Glu Ala Asp Tyr Leu Trp Lys Lys Tyr Arg Glu Ser Ile Arg Glu 
    450                 455                 460                 


Val Ala Asp Ala Leu Asp Val Asp Asn Ile Lys Asn Leu Ser Gly Ser 
465                 470                 475                 480 


Asn Ile Glu Ile Arg Asp Asn Glu Leu Arg Lys Cys Phe Ile Ser Tyr 
                485                 490                 495     


Ala Asp Ser Val Ser Glu Phe Thr Lys Leu Ile Tyr Leu Leu Thr Arg 
            500                 505                 510         


Phe Leu Ser Gly Lys Glu Ile Asn Asp Leu Val Thr Thr Leu Ile Asn 
        515                 520                 525             


Lys Phe Asp Asn Ile Arg Ser Phe Leu Glu Ile Met Asp Glu Leu Gly 
    530                 535                 540                 


Leu Asp Arg Thr Phe Thr Ala Glu Tyr Ser Phe Phe Glu Asp Ser Thr 
545                 550                 555                 560 


Lys Tyr Leu Ala Glu Leu Val Glu Leu Asn Ser Phe Val Lys Ser Cys 
                565                 570                 575     


Ser Phe Asp Ile Asn Ala Lys Arg Thr Met Tyr Arg Asp Ala Leu Asp 
            580                 585                 590         


Ile Leu Gly Ile Lys Ser Gly Lys Thr Glu Glu Asp Ile Glu Lys Met 
        595                 600                 605             


Ile Asp Asn Ile Leu Gln Ile Asp Ala Asn Gly Asp Lys Lys Leu Lys 
    610                 615                 620                 


Lys Asn Asn Gly Leu Arg Asn Phe Ile Ala Ser Asn Val Ile Asp Ser 
625                 630                 635                 640 


Asn Arg Phe Lys Tyr Leu Val Arg Tyr Gly Asn Pro Lys Lys Ile Arg 
                645                 650                 655     


Glu Thr Ala Lys Cys Lys Pro Ala Val Arg Phe Val Leu Asn Glu Ile 
            660                 665                 670         


Pro Asp Ala Gln Ile Glu Arg Tyr Tyr Glu Ala Cys Cys Pro Glu Asn 
        675                 680                 685             


Thr Ala Leu Cys Ser Ala Asn Lys Lys Arg Glu Lys Leu Ala Asp Met 
    690                 695                 700                 


Ile Ala Glu Ile Glu Phe Glu Asn Phe Ser Asp Ala Gly Asn Tyr Gln 
705                 710                 715                 720 


Lys Ala Asn Val Thr Ser Lys Thr His Glu Ala Glu Ile Lys Arg Lys 
                725                 730                 735     


Asn Gln Ser Ile Ile Arg Leu Tyr Leu Thr Val Met Tyr Ile Met Leu 
            740                 745                 750         


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Phe His Cys 
        755                 760                 765             


Val Glu Arg Asp Thr Lys Leu Tyr Ala Glu Ser Gly Leu Glu Val Gly 
    770                 775                 780                 


Asn Ile Glu Lys Asn Lys Thr Asn Leu Thr Met Ala Val Met Gly Val 
785                 790                 795                 800 


Lys Leu Glu Asn Gly Ile Ile Lys Thr Glu Phe Asp Lys Ser Leu Ala 
                805                 810                 815     


Glu Asn Ala Ala Asn Arg Tyr Leu Arg Asn Ala Arg Trp Tyr Lys Leu 
            820                 825                 830         


Ile Leu Asp Asn Leu Lys Lys Ser Glu Arg Ala Val Val Asn Glu Phe 
        835                 840                 845             


Arg Asn Thr Val Cys His Leu Asn Ala Ile Arg Asn Ile Asn Ile Asn 
    850                 855                 860                 


Ile Lys Glu Ile Lys Glu Val Glu Asn Tyr Phe Ala Leu Tyr His Tyr 
865                 870                 875                 880 


Leu Ile Gln Lys His Leu Glu Asn Arg Phe Ala Asp Lys Lys Val Glu 
                885                 890                 895     


Arg Asp Thr Gly Asp Phe Ile Ser Lys Leu Glu Glu His Lys Thr Tyr 
            900                 905                 910         


Cys Lys Asp Phe Val Lys Ala Tyr Cys Thr Pro Phe Gly Tyr Asn Leu 
        915                 920                 925             


Val Arg Tyr Lys Asn Leu Thr Ile Asp Gly Leu Phe Asp Lys Asn Tyr 
    930                 935                 940                 


Pro Gly Lys Asp Asp Ser Asp Glu Gln Lys 
945                 950                 


<210>  3132
<211>  954
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3132

Met Gly Lys Lys Ile His Ala Arg Asp Leu Arg Glu Gln Arg Lys Thr 
1               5                   10                  15      


Asp Arg Thr Val Lys Phe Ala Asp Gln Asn Lys Lys Arg Glu Ala Glu 
            20                  25                  30          


Arg Ala Val Gln Lys Lys Asp Ala Ala Val Ser Val Lys Ser Val Pro 
        35                  40                  45              


Ser Val Ser Ser Lys Lys Asp Asn Val Thr Lys Ser Met Ala Lys Ala 
    50                  55                  60                  


Ala Gly Val Lys Ser Val Phe Ala Val Gly Asn Thr Val Tyr Met Thr 
65                  70                  75                  80  


Ser Phe Gly Arg Gly Asn Asp Ala Val Leu Glu Gln Lys Ile Val Asp 
                85                  90                  95      


Thr Ser His Glu Pro Leu Asn Ile Asp Asp Pro Ala Tyr Gln Leu Asn 
            100                 105                 110         


Val Val Thr Met Asn Gly Tyr Ser Val Ile Gly His Arg Gly Glu Thr 
        115                 120                 125             


Val Ser Ala Val Thr Asp Asn Pro Leu Arg Arg Phe Asn Gly Gly Lys 
    130                 135                 140                 


Lys Asp Glu Pro Glu Gln Ser Val Pro Thr Asp Met Leu Cys Leu Lys 
145                 150                 155                 160 


Pro Thr Leu Glu Lys Lys Phe Phe Gly Lys Glu Phe Asp Asp Asn Ile 
                165                 170                 175     


His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala 
            180                 185                 190         


Val Tyr Ser Thr Asn Ala Ile Tyr Ala Leu Asn Asn Met Ser Ala Asp 
        195                 200                 205             


Glu Asn Ile Glu Asn Ser Asp Phe Phe Met Lys Arg Thr Thr Asp Glu 
    210                 215                 220                 


Thr Phe Asp Asp Phe Glu Lys Lys Lys Glu Ser Thr Asn Ser Arg Glu 
225                 230                 235                 240 


Lys Ala Asp Phe Asp Ala Phe Glu Lys Phe Ile Gly Asn Tyr Arg Leu 
                245                 250                 255     


Ala Tyr Phe Ala Asp Ala Phe Tyr Val Asn Lys Lys Asn Pro Lys Gly 
            260                 265                 270         


Lys Ala Lys Asn Val Leu Arg Glu Asp Lys Glu Leu Tyr Ser Val Leu 
        275                 280                 285             


Thr Leu Ile Gly Lys Leu Arg His Trp Cys Val His Ser Glu Glu Gly 
    290                 295                 300                 


Arg Ala Glu Phe Trp Leu Tyr Lys Leu Asp Glu Leu Lys Asp Asp Phe 
305                 310                 315                 320 


Lys Asn Val Leu Asp Val Val Tyr Asn Arg Pro Val Glu Glu Ile Asn 
                325                 330                 335     


Asn Arg Phe Ile Glu Asn Asn Lys Val Asn Ile Gln Ile Leu Gly Ser 
            340                 345                 350         


Val Tyr Lys Asn Thr Asp Ile Ala Glu Leu Val Arg Ser Tyr Tyr Glu 
        355                 360                 365             


Phe Leu Ile Thr Lys Lys Tyr Lys Asn Met Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Ser Met Leu Glu Gly Lys Gly Tyr Ala Asp Lys Glu Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Asn Lys Leu Tyr Gln Met Thr Asp Phe Ile Leu Tyr 
                405                 410                 415     


Thr Gly Tyr Ile Asn Glu Asp Ser Asp Arg Ala Asp Asp Leu Val Asn 
            420                 425                 430         


Thr Leu Arg Ser Ser Leu Lys Glu Asp Asp Lys Thr Thr Val Tyr Cys 
        435                 440                 445             


Lys Glu Ala Asp Tyr Leu Trp Lys Lys Tyr Arg Glu Ser Ile Arg Glu 
    450                 455                 460                 


Val Ala Asp Ala Leu Asp Val Asp Asn Ile Lys Asn Leu Ser Gly Ser 
465                 470                 475                 480 


Asn Ile Glu Ile Arg Asp Asn Glu Leu Arg Lys Cys Phe Ile Ser Tyr 
                485                 490                 495     


Ala Asp Ser Val Ser Glu Phe Thr Lys Leu Ile Tyr Leu Leu Thr Arg 
            500                 505                 510         


Phe Leu Ser Gly Lys Glu Ile Asn Asp Leu Val Thr Thr Leu Ile Asn 
        515                 520                 525             


Lys Phe Asp Asn Ile Arg Ser Phe Leu Glu Ile Met Asp Glu Leu Gly 
    530                 535                 540                 


Leu Asp Arg Thr Phe Thr Ala Glu Tyr Ser Phe Phe Glu Asp Ser Thr 
545                 550                 555                 560 


Lys Tyr Leu Ala Glu Leu Val Glu Leu Asn Ser Phe Val Lys Ser Cys 
                565                 570                 575     


Ser Phe Asp Ile Asn Ala Lys Arg Thr Met Tyr Arg Asp Ala Leu Asp 
            580                 585                 590         


Ile Leu Gly Ile Lys Ser Gly Lys Thr Glu Glu Asp Ile Glu Lys Met 
        595                 600                 605             


Ile Asp Asn Ile Leu Gln Ile Asp Ala Asn Gly Asp Lys Lys Leu Lys 
    610                 615                 620                 


Lys Asn Asn Gly Leu Arg Asn Phe Ile Ala Ser Asn Val Ile Asp Ser 
625                 630                 635                 640 


Asn Arg Phe Lys Tyr Leu Val Arg Tyr Gly Asn Pro Lys Lys Ile Arg 
                645                 650                 655     


Glu Thr Ala Lys Cys Lys Pro Ala Val Arg Phe Val Leu Asn Glu Ile 
            660                 665                 670         


Pro Asp Ala Gln Ile Glu Arg Tyr Tyr Glu Ala Cys Cys Pro Glu Asn 
        675                 680                 685             


Thr Ala Leu Cys Ser Ala Asn Lys Lys Arg Glu Lys Leu Ala Asp Met 
    690                 695                 700                 


Ile Ala Glu Ile Glu Phe Glu Asn Phe Ser Asp Ala Gly Asn Tyr Gln 
705                 710                 715                 720 


Lys Ala Asn Val Thr Ser Lys Thr His Glu Ala Glu Ile Lys Arg Lys 
                725                 730                 735     


Asn Gln Ser Ile Ile Arg Leu Tyr Leu Thr Val Met Tyr Ile Met Leu 
            740                 745                 750         


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Phe His Cys 
        755                 760                 765             


Val Glu Arg Asp Thr Lys Leu Tyr Ala Glu Ser Gly Leu Glu Val Gly 
    770                 775                 780                 


Asn Ile Glu Lys Asn Lys Thr Asn Leu Thr Met Ala Val Met Gly Val 
785                 790                 795                 800 


Lys Leu Glu Asn Gly Ile Ile Lys Thr Glu Phe Asp Lys Ser Leu Ala 
                805                 810                 815     


Glu Asn Ala Ala Asn Arg Tyr Leu Arg Asn Ala Arg Trp Tyr Lys Leu 
            820                 825                 830         


Ile Leu Asp Asn Leu Lys Lys Ser Glu Arg Ala Val Val Asn Glu Phe 
        835                 840                 845             


Arg Asn Thr Val Cys His Leu Asn Ala Ile Arg Asn Ile Asn Ile Asn 
    850                 855                 860                 


Ile Lys Glu Ile Lys Glu Val Glu Asn Tyr Phe Ala Leu Tyr His Tyr 
865                 870                 875                 880 


Leu Ile Gln Lys His Leu Glu Asn Arg Phe Ala Asp Lys Lys Val Glu 
                885                 890                 895     


Arg Asp Thr Gly Asp Phe Ile Ser Lys Leu Glu Glu His Lys Thr Tyr 
            900                 905                 910         


Cys Lys Asp Phe Val Lys Ala Tyr Cys Thr Pro Phe Gly Tyr Asn Leu 
        915                 920                 925             


Val Arg Tyr Lys Asn Leu Thr Ile Asp Gly Leu Phe Asp Lys Asn Tyr 
    930                 935                 940                 


Pro Gly Lys Asp Asp Ser Asp Glu Gln Lys 
945                 950                 


<210>  3133
<211>  924
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3133

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Phe Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Leu Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Leu Ser Glu His Ser Glu Tyr Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asp Asn Ser Lys Lys Val Tyr Arg Glu Cys Arg Glu Thr Leu 
305                 310                 315                 320 


Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile 
                325                 330                 335     


Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly 
            340                 345                 350         


Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu 
        355                 360                 365             


Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys 
    370                 375                 380                 


Ile Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser 
385                 390                 395                 400 


Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn 
                405                 410                 415     


Tyr Tyr Arg Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu 
            420                 425                 430         


Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu 
        435                 440                 445             


Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala 
    450                 455                 460                 


Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met 
465                 470                 475                 480 


Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp 
                485                 490                 495     


Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp 
            500                 505                 510         


Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp 
        515                 520                 525             


Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Ile Asp Val 
    530                 535                 540                 


Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg 
545                 550                 555                 560 


Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys 
                565                 570                 575     


Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile 
            580                 585                 590         


Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu 
        595                 600                 605             


Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile 
    610                 615                 620                 


Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr 
625                 630                 635                 640 


Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val 
                645                 650                 655     


Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr 
            660                 665                 670         


Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys 
        675                 680                 685             


Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe 
    690                 695                 700                 


Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu 
705                 710                 715                 720 


Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu 
                725                 730                 735     


Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His 
            740                 745                 750         


Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu 
        755                 760                 765             


Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu 
    770                 775                 780                 


Cys Glu Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys 
785                 790                 795                 800 


Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala 
                805                 810                 815     


Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr 
            820                 825                 830         


Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp 
        835                 840                 845             


Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys 
    850                 855                 860                 


Arg Glu Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp 
865                 870                 875                 880 


Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn 
                885                 890                 895     


Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu 
            900                 905                 910         


Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 


<210>  3134
<211>  1001
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3134

Met Gly Lys Lys Ile His Ala Arg Asp Leu Arg Glu Gln Arg Lys Asn 
1               5                   10                  15      


Asp Arg Thr Ala Lys Phe Ala Val Gln Asn Lys Lys Cys Glu Ala Gln 
            20                  25                  30          


Arg Ala Val Gln Lys Lys Asp Ala Ala Val Ser Ala Lys Ser Val Ser 
        35                  40                  45              


Ser Val Ser Ser Lys Lys Asp Asn Ala Thr Lys Ser Met Ala Lys Ala 
    50                  55                  60                  


Ala Gly Val Lys Ser Val Phe Ala Val Gly Asn Thr Val Tyr Met Thr 
65                  70                  75                  80  


Ser Phe Gly Arg Gly Asn Asp Ala Val Leu Glu Gln Lys Ile Val Asp 
                85                  90                  95      


Thr Ser His Glu Pro Leu Asn Ile Asp Asp Pro Ala Tyr Gln Leu Asn 
            100                 105                 110         


Val Val Thr Met Asn Gly Tyr Ser Val Thr Gly His Arg Gly Glu Thr 
        115                 120                 125             


Val Ser Ala Val Thr Asp Asn Pro Leu Arg Arg Phe Asn Gly Gly Lys 
    130                 135                 140                 


Lys Asp Glu Pro Glu Gln Ser Val Pro Thr Asp Met Leu Cys Leu Lys 
145                 150                 155                 160 


Pro Thr Leu Glu Lys Lys Phe Phe Gly Lys Glu Phe Asn Asp Asn Ile 
                165                 170                 175     


His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala 
            180                 185                 190         


Val Tyr Ser Thr Asn Ala Val Tyr Ala Leu Asn Asn Thr Ile Ala Asp 
        195                 200                 205             


Glu Asn Asp Glu Asn Trp Asp Leu Phe Ala Asn Phe Ser Thr Asp Asn 
    210                 215                 220                 


Thr Tyr Tyr Glu Leu Arg Asn Ala Ala Ala Tyr Lys Glu Ser Ala Asp 
225                 230                 235                 240 


Asp Glu Ser Thr Asp Asp Glu Lys Arg Arg Glu Ala Glu Lys Lys Lys 
                245                 250                 255     


Arg Glu Ala Lys Lys Ala Glu Lys Ile Leu Ala Asp Tyr Glu Lys Phe 
            260                 265                 270         


Arg Lys Asn Asn Arg Leu Ala Tyr Phe Ala Asp Ala Phe Tyr Val Asp 
        275                 280                 285             


Lys Asn Lys Ser Lys Ser Lys Ser Lys Asp Lys Ala Glu Gly Ile Gln 
    290                 295                 300                 


Arg Gly Lys Lys Glu Ile Tyr Ser Ile Leu Ala Leu Ile Ala Lys Leu 
305                 310                 315                 320 


Arg His Trp Cys Val His Ser Glu Asp Gly Arg Ala Glu Phe Trp Leu 
                325                 330                 335     


Tyr Lys Leu Asp Glu Leu Lys Asp Asp Phe Lys Asn Val Leu Asp Val 
            340                 345                 350         


Val Tyr Asn Arg Pro Val Glu Glu Ile Asn Asn Arg Phe Ile Glu Asn 
        355                 360                 365             


Asn Lys Val Asn Ile Gln Ile Leu Asp Ser Val Tyr Glu Asn Thr Asp 
    370                 375                 380                 


Ile Ala Glu Leu Thr Arg Ser Tyr Tyr Glu Phe Leu Ile Thr Lys Lys 
385                 390                 395                 400 


Tyr Lys Asn Met Gly Phe Ser Ile Lys Lys Leu Arg Glu Ser Met Leu 
                405                 410                 415     


Glu Gly Lys Gly Tyr Ala Asp Lys Glu Tyr Asp Ser Val Arg Asn Lys 
            420                 425                 430         


Leu Tyr Gln Met Thr Asp Phe Ile Leu Tyr Thr Gly Tyr Ile Asn Glu 
        435                 440                 445             


Asp Ser Asp Arg Ala Asp Asp Leu Val Asn Thr Leu Arg Ser Ser Leu 
    450                 455                 460                 


Lys Glu Asp Asp Lys Thr Thr Val Tyr Cys Lys Glu Ala Asp Tyr Leu 
465                 470                 475                 480 


Trp Lys Lys Tyr Arg Glu Ser Ile Arg Glu Val Ala Asp Ala Leu Asp 
                485                 490                 495     


Gly Asp Asn Ile Lys Lys Leu Ser Lys Ser Asn Ile Glu Ile Gln Glu 
            500                 505                 510         


Asp Lys Leu Arg Lys Cys Phe Ile Ser Tyr Ala Asp Ser Val Ser Glu 
        515                 520                 525             


Phe Thr Lys Leu Ile Tyr Leu Leu Thr Arg Phe Leu Ser Gly Lys Glu 
    530                 535                 540                 


Ile Asn Asp Leu Val Thr Thr Leu Ile Asn Lys Phe Asp Asn Ile Arg 
545                 550                 555                 560 


Ser Phe Leu Glu Ile Met Asp Glu Leu Gly Leu Asp Arg Thr Phe Thr 
                565                 570                 575     


Ala Glu Tyr Ser Phe Phe Glu Gly Ser Thr Lys Tyr Leu Ala Glu Leu 
            580                 585                 590         


Val Glu Leu Asn Ser Phe Val Lys Ser Cys Ser Phe Asp Met Ser Ala 
        595                 600                 605             


Lys Arg Thr Met Tyr Arg Asp Ala Leu Asp Ile Leu Gly Ile Glu Ser 
    610                 615                 620                 


Asp Lys Thr Glu Glu Asp Ile Glu Lys Met Ile Asp Asn Ile Leu Gln 
625                 630                 635                 640 


Val Asp Ala Asn Gly Lys Lys Leu Pro Asn Lys Asn His Gly Leu Arg 
                645                 650                 655     


Asn Phe Ile Ala Ser Asn Val Ile Asp Ser Asn Arg Phe Glu Tyr Leu 
            660                 665                 670         


Val Arg Tyr Gly Asn Pro Lys Lys Ile Arg Glu Thr Ala Lys Cys Glu 
        675                 680                 685             


Pro Ala Val Arg Phe Val Leu Asn Glu Ile Pro Asp Ala Gln Ile Glu 
    690                 695                 700                 


Arg Tyr Tyr Lys Ala Tyr Tyr Pro Asp Glu Lys Ser Leu Cys Leu Ala 
705                 710                 715                 720 


Asn Met Gln Arg Asp Lys Leu Ala Asp Met Ile Ala Glu Ile Lys Phe 
                725                 730                 735     


Glu Asn Phe Ser Asp Ala Gly Ser Tyr Gln Glu Ala Asn Ala Thr Ser 
            740                 745                 750         


Thr Arg Ile Thr Ser Glu Ala Glu Ile Lys Arg Lys Asn Gln Ala Ile 
        755                 760                 765             


Ile Arg Leu Tyr Leu Thr Val Met Tyr Ile Met Leu Lys Asn Leu Val 
    770                 775                 780                 


Asn Val Asn Ala Arg Tyr Val Ile Ala Phe His Cys Leu Glu Arg Asp 
785                 790                 795                 800 


Ala Lys Leu Tyr Ser Glu Ser Val Leu Lys Val Gly Asn Thr Asn Glu 
                805                 810                 815     


Glu Ser Arg Leu Gln Thr Gly Asn Thr Asn Glu Glu Lys Asn Lys Val 
            820                 825                 830         


Lys Leu Thr Asn Leu Thr Asn Leu Thr Met Ala Val Met Gly Val Lys 
        835                 840                 845             


Leu Glu Asn Gly Thr Ile Lys Thr Glu Phe Asp Lys Ser Leu Ala Glu 
    850                 855                 860                 


Asn Ala Ala Asn Arg Tyr Leu Arg Asn Ala Arg Trp Tyr Lys Leu Ile 
865                 870                 875                 880 


Leu Asp Asn Leu Lys Lys Ser Glu Arg Ala Val Val Thr Glu Phe Arg 
                885                 890                 895     


Asn Thr Val Cys His Leu Asn Ala Ile Arg Asn Ile Asn Ile Asn Ile 
            900                 905                 910         


Lys Glu Val Lys Glu Val Glu Asn Tyr Phe Ala Leu Tyr His Tyr Leu 
        915                 920                 925             


Ile Gln Lys His Leu Glu Lys Arg Phe Ala Asp Lys Lys Val Glu Arg 
    930                 935                 940                 


Asp Thr Gly Asp Phe Ile Ser Lys Leu Glu Glu His Lys Thr Tyr Cys 
945                 950                 955                 960 


Lys Asp Phe Val Lys Ala Tyr Cys Thr Pro Phe Gly Tyr Asn Leu Val 
                965                 970                 975     


Arg Tyr Lys Asn Leu Thr Ile Asp Gly Leu Phe Asp Lys Asn Tyr Pro 
            980                 985                 990         


Gly Lys Asp Asp Ser Asp Glu Gln  Lys 
        995                 1000     


<210>  3135
<211>  927
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3135

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Thr Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asp Tyr Asn 
                85                  90                  95      


Gln Thr Gln Leu Ser Ser Lys Asp Ser Ser Asn Ile Glu Leu His Gly 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Leu Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Ser Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Asp Ser Asn 
        195                 200                 205             


Tyr Asp Phe Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe 
    210                 215                 220                 


Thr Asn Pro Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Lys Asn Ile 
225                 230                 235                 240 


Arg Lys Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu 
                245                 250                 255     


Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Asn Ala Leu 
            260                 265                 270         


Glu Ala Tyr Lys Lys Arg Val Tyr Tyr Met Leu Ala Ile Val Gly Gln 
        275                 280                 285             


Ile Arg Gln Cys Val Phe His Asp Leu Thr Asp His Ser Glu Tyr Asp 
    290                 295                 300                 


Leu Tyr Ser Phe Ile Tyr Asn Ser Lys Lys Val Tyr Lys Glu Cys Arg 
305                 310                 315                 320 


Glu Thr Leu Asp Tyr Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys 
                325                 330                 335     


Gly Phe Ile Glu Gly Asn Lys Ile Asn Ile Ser Leu Leu Ile Asp Met 
            340                 345                 350         


Met Lys Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe 
        355                 360                 365             


Ile Val Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu 
    370                 375                 380                 


Arg Glu Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln 
385                 390                 395                 400 


Tyr Asp Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu 
                405                 410                 415     


Phe Cys Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val 
            420                 425                 430         


Arg Lys Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr 
        435                 440                 445             


Ala Asp Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu 
    450                 455                 460                 


Asn Ile Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys 
465                 470                 475                 480 


Ala Asp Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn 
                485                 490                 495     


Ala Ser Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr 
            500                 505                 510         


Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser 
        515                 520                 525             


Lys Phe Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala 
    530                 535                 540                 


Val Asp Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp 
545                 550                 555                 560 


Ser Gln Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser 
                565                 570                 575     


Met Arg Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala 
            580                 585                 590         


Leu Thr Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser 
        595                 600                 605             


Glu Ile Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg 
    610                 615                 620                 


Asn Phe Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu 
625                 630                 635                 640 


Ile Lys Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu 
                645                 650                 655     


Lys Val Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu 
            660                 665                 670         


Arg Tyr Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu 
        675                 680                 685             


Glu Ala Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe 
    690                 695                 700                 


Asp Asp Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val 
705                 710                 715                 720 


Ala Lys Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met 
                725                 730                 735     


Tyr Leu Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile 
            740                 745                 750         


Ala Ile His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile 
        755                 760                 765             


Pro Glu Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser 
    770                 775                 780                 


Gln Thr Leu Cys Glu Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu 
785                 790                 795                 800 


Phe Leu Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile 
                805                 810                 815     


Asn Asn Ala Asp Ser Ile Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala 
            820                 825                 830         


His Leu Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg 
        835                 840                 845             


Thr Val Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys 
    850                 855                 860                 


Ile Thr Lys Arg Glu Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr 
865                 870                 875                 880 


Glu Asp Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys 
                885                 890                 895     


Ala Leu Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu 
            900                 905                 910         


Ser Ile Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925         


<210>  3136
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3136

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Lys Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asn Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Asp Glu Ser His Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe Thr Asp 
    210                 215                 220                 


Pro Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Asn Ala Leu Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Pro Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp Asp Ile 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  3137
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3137

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Lys Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asn Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Asp Glu Ser His Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe Thr Asp 
    210                 215                 220                 


Pro Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Asn Ala Leu Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Pro Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp Asp Ile 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  3138
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3138

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Ile Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Pro Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn His Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3139
<211>  952
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3139

Met Gly Lys Lys Ile His Ala Arg Asp Leu Arg Glu Gln Arg Lys Thr 
1               5                   10                  15      


Asp Arg Thr Glu Lys Phe Ala Asp Gln Asn Lys Lys Arg Glu Ala Glu 
            20                  25                  30          


Arg Ala Val Gln Lys Lys Asp Ala Ala Val Ser Val Lys Ser Val Ser 
        35                  40                  45              


Ser Val Ser Ser Lys Lys Asp Asn Val Thr Lys Ser Met Ala Lys Ala 
    50                  55                  60                  


Ala Gly Val Lys Ser Val Phe Ala Val Gly Asn Thr Val Tyr Met Thr 
65                  70                  75                  80  


Ser Phe Gly Arg Gly Asn Asp Ala Val Leu Glu Gln Lys Ile Val Asp 
                85                  90                  95      


Thr Ser His Glu Pro Leu Asn Ile Asp Asp Pro Ala Tyr Gln Leu Asn 
            100                 105                 110         


Val Val Thr Met Asn Gly Tyr Ser Val Thr Gly His Arg Gly Glu Thr 
        115                 120                 125             


Val Ser Ala Val Thr Asp Asn Pro Leu Arg Arg Phe Asn Gly Gly Lys 
    130                 135                 140                 


Lys Asp Glu Pro Glu Gln Ser Val Pro Thr Asp Met Leu Cys Leu Lys 
145                 150                 155                 160 


Pro Thr Leu Glu Lys Lys Phe Phe Gly Lys Glu Phe Asp Asp Asn Ile 
                165                 170                 175     


His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala 
            180                 185                 190         


Val Tyr Ser Thr Asn Ala Ile Tyr Ala Leu Asn Asn Met Ser Ala Asp 
        195                 200                 205             


Glu Asn Ile Glu Asn Ser Asp Phe Phe Met Lys Arg Thr Thr Asp Glu 
    210                 215                 220                 


Thr Phe Asp Asp Phe Glu Lys Lys Lys Glu Ser Thr Asn Ser Arg Glu 
225                 230                 235                 240 


Lys Ala Asp Phe Asp Ala Phe Glu Lys Phe Ile Gly Asn Tyr Arg Leu 
                245                 250                 255     


Ala Tyr Phe Ala Asp Ala Phe Tyr Val Asn Lys Lys Asn Pro Lys Gly 
            260                 265                 270         


Lys Ala Arg Asn Val Leu Arg Glu Asp Lys Glu Leu Tyr Ser Val Leu 
        275                 280                 285             


Thr Leu Ile Gly Lys Leu Arg His Trp Cys Val His Ser Glu Glu Gly 
    290                 295                 300                 


Arg Ala Glu Phe Trp Leu Tyr Lys Leu Asp Glu Leu Lys Asp Asp Phe 
305                 310                 315                 320 


Lys Asn Val Leu Asp Val Val Tyr Asn Arg Pro Val Glu Glu Ile Asn 
                325                 330                 335     


Asn Arg Phe Ile Glu Asn Asn Lys Val Asn Ile Gln Ile Leu Gly Ser 
            340                 345                 350         


Val Tyr Lys Asn Thr Asp Ile Ala Glu Leu Val Arg Ser Tyr Tyr Glu 
        355                 360                 365             


Phe Leu Ile Thr Lys Lys Tyr Lys Asn Met Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Ser Met Leu Glu Gly Lys Gly Tyr Ala Asp Lys Glu Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Asn Lys Leu Tyr Gln Met Thr Asp Phe Ile Leu Tyr 
                405                 410                 415     


Thr Gly Tyr Ile Asn Glu Asp Ser Asp Arg Ala Asp Asp Leu Val Asn 
            420                 425                 430         


Thr Leu Arg Ser Ser Leu Lys Glu Asp Asp Lys Thr Thr Val Tyr Cys 
        435                 440                 445             


Lys Glu Ala Asp Tyr Leu Trp Lys Lys Tyr Arg Glu Ser Ile Arg Glu 
    450                 455                 460                 


Val Ala Asp Ala Leu Asp Gly Asp Asn Ile Lys Arg Leu Ser Lys Ser 
465                 470                 475                 480 


Asn Ile Glu Ile Gln Glu Asp Lys Leu Arg Lys Cys Phe Ile Ser Tyr 
                485                 490                 495     


Ala Asp Ser Val Ser Glu Phe Thr Lys Leu Ile Tyr Leu Leu Thr Arg 
            500                 505                 510         


Phe Leu Ser Gly Lys Glu Ile Asn Asp Leu Val Thr Thr Leu Ile Asn 
        515                 520                 525             


Lys Phe Asp Asn Ile Arg Ser Phe Leu Glu Ile Met Asp Glu Leu Gly 
    530                 535                 540                 


Leu Asp Arg Thr Phe Thr Ala Glu Tyr Ser Phe Phe Glu Gly Ser Thr 
545                 550                 555                 560 


Lys Tyr Leu Ala Glu Leu Val Glu Leu Asn Ser Phe Val Lys Ser Cys 
                565                 570                 575     


Ser Phe Asp Ile Asn Ala Lys Arg Thr Met Tyr Arg Asp Ala Leu Asp 
            580                 585                 590         


Ile Leu Gly Ile Lys Ser Gly Lys Thr Glu Glu Asp Ile Glu Lys Met 
        595                 600                 605             


Ile Asp Asn Ile Leu Gln Ile Asp Ala Asn Gly Asp Lys Lys Leu Lys 
    610                 615                 620                 


Lys Asn Asn Gly Leu Arg Asn Phe Ile Ala Ser Asn Val Ile Asp Ser 
625                 630                 635                 640 


Asn Arg Phe Lys Tyr Leu Val Arg Tyr Gly Asn Pro Lys Lys Ile Arg 
                645                 650                 655     


Glu Thr Ala Lys Cys Lys Pro Ala Val Arg Phe Val Leu Asn Glu Ile 
            660                 665                 670         


Pro Asp Ala Gln Ile Glu Arg Tyr Tyr Glu Ala Cys Cys Pro Lys Asn 
        675                 680                 685             


Thr Ala Leu Cys Ser Ala Asn Lys Arg Arg Glu Lys Leu Ala Asp Met 
    690                 695                 700                 


Ile Ala Glu Ile Lys Phe Glu Asn Phe Ser Asp Ala Gly Asn Tyr Gln 
705                 710                 715                 720 


Lys Ala Asn Val Thr Ser Lys Thr His Glu Ala Glu Ile Lys Arg Lys 
                725                 730                 735     


Asn Gln Ala Ile Ile Arg Leu Tyr Leu Thr Val Met Tyr Ile Met Leu 
            740                 745                 750         


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Phe His Cys 
        755                 760                 765             


Val Glu Arg Asp Thr Lys Leu Tyr Ala Glu Ser Gly Leu Glu Val Gly 
    770                 775                 780                 


Asn Ile Glu Lys Asn Lys Thr Asn Leu Thr Met Ala Val Met Gly Val 
785                 790                 795                 800 


Lys Leu Glu Asn Gly Ile Ile Lys Thr Glu Phe Asp Lys Ser Leu Ala 
                805                 810                 815     


Glu Asn Ala Ala Asn Arg Tyr Leu Arg Asn Ala Arg Trp Tyr Lys Leu 
            820                 825                 830         


Ile Leu Asp Asn Leu Lys Lys Ser Glu Arg Ala Val Val Asn Glu Phe 
        835                 840                 845             


Arg Asn Thr Val Cys His Leu Asn Ala Ile Arg Asn Ile Asn Ile Asn 
    850                 855                 860                 


Ile Asp Gly Ile Lys Glu Val Glu Asn Tyr Phe Ala Leu Tyr His Tyr 
865                 870                 875                 880 


Leu Ile Gln Lys His Leu Glu Asn Arg Phe Ala Asp Asn Gly Gly Ser 
                885                 890                 895     


Thr Gly Asp Tyr Ile Gly Lys Leu Glu Glu His Lys Thr Tyr Cys Lys 
            900                 905                 910         


Asp Phe Val Lys Ala Tyr Cys Thr Pro Phe Gly Tyr Asn Leu Val Arg 
        915                 920                 925             


Tyr Lys Asn Leu Thr Ile Asp Gly Leu Phe Asp Lys Asn Tyr Pro Gly 
    930                 935                 940                 


Lys Asp Asp Ser Asp Glu Gln Lys 
945                 950         


<210>  3140
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3140

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Gly Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asp Asn Asp Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Glu Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Ala Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Cys Val Phe His Asp Leu Ser Glu His Ser Glu Tyr 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Asn Ser Lys Lys Val Tyr Arg Glu Cys 
305                 310                 315                 320 


Arg Glu Thr Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn 
                325                 330                 335     


Lys Gly Phe Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp 
            340                 345                 350         


Met Met Lys Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp 
        355                 360                 365             


Phe Ile Val Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys 
385                 390                 395                 400 


Gln Tyr Asp Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu 
                405                 410                 415     


Leu Phe Cys Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu 
            420                 425                 430         


Val Arg Lys Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Thr 
        435                 440                 445             


Tyr Ala Asp Glu Ala Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe 
    450                 455                 460                 


Glu Asn Ile Ala Asp His Met Asn Gly Asp Ala Ile Lys Glu Leu Gly 
465                 470                 475                 480 


Lys Ala Asp Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys 
                485                 490                 495     


Asn Ala Ser Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr 
            500                 505                 510         


Tyr Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile 
        515                 520                 525             


Ser Lys Phe Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser 
    530                 535                 540                 


Ala Val Asp Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn 
545                 550                 555                 560 


Asp Ser Gln Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala 
                565                 570                 575     


Ser Met Arg Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp 
            580                 585                 590         


Ala Leu Thr Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile 
        595                 600                 605             


Ser Glu Ile Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu 
    610                 615                 620                 


Arg Asn Phe Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr 
625                 630                 635                 640 


Leu Ile Lys Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn 
                645                 650                 655     


Glu Lys Val Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile 
            660                 665                 670         


Glu Arg Tyr Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser 
        675                 680                 685             


Leu Glu Ala Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser 
    690                 695                 700                 


Phe Asp Asp Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn 
705                 710                 715                 720 


Val Ala Lys Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val 
                725                 730                 735     


Met Tyr Leu Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val 
            740                 745                 750         


Ile Ala Ile His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile 
        755                 760                 765             


Ile Pro Glu Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu 
    770                 775                 780                 


Ser Gln Thr Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  3141
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3141

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Phe Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Ile Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Glu 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Arg Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp Asp Thr 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  3142
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3142

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Lys Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asn Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Asp Glu Ser His Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe Thr Asp 
    210                 215                 220                 


Pro Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Asn Ala Leu Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Pro Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp Asp Ile 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  3143
<211>  921
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3143

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Lys 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Leu Glu Asn Glu Ser Asn Asn Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe Thr Asp Pro 
    210                 215                 220                 


Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn Ile Lys Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu Tyr Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Ile Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp 
    370                 375                 380                 


Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Glu Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Lys Val Ala Glu Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn Lys 
785                 790                 795                 800 


Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser 
                805                 810                 815     


Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg 
            820                 825                 830         


Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe 
        835                 840                 845             


Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp 
    850                 855                 860                 


Asp Lys Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys 
865                 870                 875                 880 


Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe 
                885                 890                 895     


Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe 
            900                 905                 910         


Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920     


<210>  3144
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3144

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Asp Glu Ser His Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn 
    210                 215                 220                 


Pro Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu Tyr Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Ile Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Glu 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asn Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Lys Lys Gln Glu Glu Lys Ile Lys Phe Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3145
<211>  924
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3145

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Phe Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Leu Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Leu Ser Glu His Ser Glu Tyr Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asp Asn Ser Lys Lys Val Tyr Arg Glu Cys Arg Glu Thr Leu 
305                 310                 315                 320 


Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile 
                325                 330                 335     


Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly 
            340                 345                 350         


Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu 
        355                 360                 365             


Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys 
    370                 375                 380                 


Ile Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser 
385                 390                 395                 400 


Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn 
                405                 410                 415     


Tyr Tyr Arg Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu 
            420                 425                 430         


Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu 
        435                 440                 445             


Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala 
    450                 455                 460                 


Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met 
465                 470                 475                 480 


Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp 
                485                 490                 495     


Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp 
            500                 505                 510         


Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp 
        515                 520                 525             


Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Ile Asp Val 
    530                 535                 540                 


Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg 
545                 550                 555                 560 


Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys 
                565                 570                 575     


Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile 
            580                 585                 590         


Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu 
        595                 600                 605             


Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile 
    610                 615                 620                 


Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr 
625                 630                 635                 640 


Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val 
                645                 650                 655     


Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr 
            660                 665                 670         


Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys 
        675                 680                 685             


Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe 
    690                 695                 700                 


Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu 
705                 710                 715                 720 


Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu 
                725                 730                 735     


Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His 
            740                 745                 750         


Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu 
        755                 760                 765             


Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu 
    770                 775                 780                 


Cys Glu Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys 
785                 790                 795                 800 


Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala 
                805                 810                 815     


Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr 
            820                 825                 830         


Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp 
        835                 840                 845             


Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys 
    850                 855                 860                 


Arg Glu Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp 
865                 870                 875                 880 


Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn 
                885                 890                 895     


Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu 
            900                 905                 910         


Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 


<210>  3146
<211>  1024
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3146

Met Ala Lys Lys Ile Thr Ala Lys Gln Arg Arg Glu Glu Arg Glu Arg 
1               5                   10                  15      


Gln Asn Lys Gln Lys Trp Ala Lys Lys Gln Asp Asp Ala Thr Ala Val 
            20                  25                  30          


Phe Glu Cys Glu Ala Asp Ile Lys Pro Ala Asp Ser Lys Asp Glu Asp 
        35                  40                  45              


Cys Ala Asn Thr Ser Ile Lys Arg Glu Lys Lys Lys Thr Gln Ala Lys 
    50                  55                  60                  


Ala Met Gly Leu Lys Thr Val Leu Gly Phe Asp Asn Lys Ile Ala Ile 
65                  70                  75                  80  


Ala Ser Phe Thr Ser Ser Lys Asp Ser Lys Ser Ser His Ile Glu Arg 
                85                  90                  95      


Ile Thr Asp Pro Asn Gly Lys Thr Ile Arg Glu Asp Val Arg Met Phe 
            100                 105                 110         


Asp Ser Asn Val Asp Glu Cys Ser Ile Asn Leu Glu Lys Arg Met Thr 
        115                 120                 125             


Val Glu Glu Arg Gln Lys Asp Gly Thr Ile Lys Lys Asp Glu Lys Asp 
    130                 135                 140                 


Val Lys Ser Thr Ile Cys Asn Pro Tyr Ser Asn Glu Cys Gly Lys Asp 
145                 150                 155                 160 


Tyr Ile Gly Ile Lys Ser Val Ala Glu Glu Leu Phe Phe Gly Arg Thr 
                165                 170                 175     


Phe Pro Asn Asp Asn Leu Arg Val Gln Ile Ala Tyr Asn Ile Phe Asp 
            180                 185                 190         


Ile Gln Lys Ile Phe Gly Thr Tyr Ile Asn Asn Ile Ile Tyr Ser Phe 
        195                 200                 205             


Tyr Asn Leu Ser Arg Asp Glu Phe Gln Ser Asp Asn Asp Val Ile Gly 
    210                 215                 220                 


Thr Leu Tyr Met Leu Lys Asp Phe Asp Gly Gln Lys Glu Thr Asp Thr 
225                 230                 235                 240 


Phe Arg Gln Ala Lys Ala Leu Leu Glu Arg Thr Glu Ala Tyr Tyr Ser 
                245                 250                 255     


Tyr Phe Asp Asn Val Phe Lys Lys Ile Asp Lys Lys Lys Lys Arg Asn 
            260                 265                 270         


Asp Asp Tyr Glu Gly Glu Arg Asn Glu Ile Leu Arg Tyr Asn Phe Asn 
        275                 280                 285             


Val Leu Arg Val Leu Ser Phe Leu Arg Gln Ile Cys Ala His Ala Lys 
    290                 295                 300                 


Val Lys Val Ser Ser Asp Asn Asp Arg Glu Lys Gly Gly Val Phe Val 
305                 310                 315                 320 


Asp Ser Leu Asp Ala Leu Phe Asn Ile Ser Arg Phe Phe Asp Ala Val 
                325                 330                 335     


Ala Pro Glu Leu Asn Glu Val Ile Asn Ser Val Tyr Ser Lys Gly Ile 
            340                 345                 350         


Asp Asp Ile Asn Asp Asn Phe Val Lys Asn Gly Lys Asn Asn Phe Tyr 
        355                 360                 365             


Ile Leu Ser Lys Ile Tyr Pro Glu Val Ala Arg Glu Asp Leu Leu Lys 
    370                 375                 380                 


Glu Tyr Tyr Tyr Phe Val Val Ser Lys Glu Gly Asn Asn Ile Gly Ile 
385                 390                 395                 400 


Ser Thr Lys Lys Leu Lys Glu Ala Ile Ile Ala Gln Asp Met Ser Tyr 
                405                 410                 415     


Ile Lys Ser Lys Asp Tyr Asp Thr Tyr Arg Asn Lys Leu Tyr Thr Val 
            420                 425                 430         


Leu Cys Phe Ile Leu Val Lys Glu Leu Asn Glu Arg Thr Thr Ile Arg 
        435                 440                 445             


Glu Gln Met Val Ala Asp Leu Arg Ala Asn Met Asn Gly Asp Ile Gly 
    450                 455                 460                 


Arg Glu Asp Ile Tyr Ser Lys Tyr Ala Lys Ile Ile Tyr Ala Gln Val 
465                 470                 475                 480 


Lys Pro Arg Phe Asp Ala Met Lys Asn Val Phe Glu Glu Glu Ala Lys 
                485                 490                 495     


Gly Val Ile Val Pro Asp Lys Glu Asp Thr Val Lys Phe Ser Asn Gly 
            500                 505                 510         


Ala Leu Asp Lys Ser Glu Ile Glu Arg Phe Cys Ile Thr Ser Ala Asn 
        515                 520                 525             


Thr Asp Ser Val Ala Lys Ile Ile Tyr Phe Leu Cys Lys Phe Leu Asp 
    530                 535                 540                 


Gly Lys Glu Ile Asn Glu Leu Cys Cys Ala Met Met Asn Lys Leu Asp 
545                 550                 555                 560 


Gly Ile Asn Asp Leu Ile Glu Thr Ala Glu Gln Cys Gly Ala Lys Ile 
                565                 570                 575     


Glu Phe Val Asp Asn Phe Asn Val Leu Ser Lys Cys Glu Thr Ile Ser 
            580                 585                 590         


Asp Gln Ile Arg Ile Val Lys Ser Ile Ser Lys Met Lys Lys Glu Ile 
        595                 600                 605             


Asp Val Asp Asn Glu Thr Ile Phe Phe Asp Ala Phe Glu Leu Leu Gly 
    610                 615                 620                 


Lys Arg Ile Glu Lys Tyr Lys Lys Asp Asp Ser Gly Asn Val Leu Arg 
625                 630                 635                 640 


Asn Asp Asp Gly Lys Val Leu Arg Thr Lys Glu Tyr Asn Asn Ile Arg 
                645                 650                 655     


Lys Met Leu Cys Lys Lys Asp Arg Arg Leu Asn Phe Ile Thr Asn Ser 
            660                 665                 670         


Ile Ile Lys Ser Lys Trp Phe Ser Tyr Ile Val Arg Tyr Asn Gln Pro 
        675                 680                 685             


Ser Glu Cys Gln Ala Ile Met Lys Asn Lys Thr Leu Val Lys Phe Ala 
    690                 695                 700                 


Leu Asp Glu Leu Pro Asp Leu Gln Ile Gln Arg Tyr Phe Val Ala Leu 
705                 710                 715                 720 


Tyr Gly Asp Glu Asp Leu Pro Ser Tyr Gly Glu Met Arg Lys Ile Leu 
                725                 730                 735     


Leu Lys Lys Leu His Asp Phe Ser Ile Arg Asp Phe Asp Glu Glu Ile 
            740                 745                 750         


Gly Ser Leu Phe Asp Glu Met Lys Arg Lys Asp Lys Phe Cys Glu Ser 
        755                 760                 765             


Asp Arg Lys Lys Cys Leu Phe Arg Leu Tyr Leu Thr Ile Ala Tyr Leu 
    770                 775                 780                 


Ile Thr Lys Ser Met Val Lys Ile Asn Thr Arg Phe Ser Ile Ala Cys 
785                 790                 795                 800 


Ala Thr Tyr Glu Arg Asp Tyr Ala Leu Leu Cys Ala Ser Asn Lys Gln 
                805                 810                 815     


Glu Arg Ala Trp Ser Ser Gly Ala Thr Ala Leu Ala Leu Thr Arg Lys 
            820                 825                 830         


Phe Leu Asn Gln Asp Lys Leu Ile Phe Glu Lys His Tyr Ala Arg Glu 
        835                 840                 845             


Gly Glu Ile Ser Lys Leu Pro Lys Glu Glu Arg Lys Ala Met Arg Lys 
    850                 855                 860                 


Val Asn Asp Gln Leu Leu Lys Gln Thr His Phe Ser Lys His Ser Tyr 
865                 870                 875                 880 


Cys Tyr Ile Val Asp Asn Val Asn Arg Leu Thr Gly Gly Glu Cys Arg 
                885                 890                 895     


Thr Asp Lys Arg Val Leu Pro Val Leu Asn Glu Lys Asn Asp Asn Ala 
            900                 905                 910         


Gly Ile Leu Pro Asp Phe Arg Lys Thr Ile Ala His Leu Asn Val Val 
        915                 920                 925             


His Lys Met Val Asp Tyr Val Gly Glu Ile Lys Gly Ile Thr Ser Tyr 
    930                 935                 940                 


Tyr Ala Phe Phe Cys Tyr Val Leu Gln Arg Met Pro Val Gly Asn Lys 
945                 950                 955                 960 


Asn Glu Lys Asn Ala Leu Lys Glu Lys Tyr Ser Glu Thr Ala Lys Ser 
                965                 970                 975     


Phe Gly Thr Tyr Ser Lys Asp Phe Met Trp Leu Ile Asn Leu Pro Phe 
            980                 985                 990         


Ala Tyr Asn Leu Pro Arg Tyr Lys  Asn Leu Ser Asn Glu  Gln Leu Phe 
        995                 1000                 1005             


Tyr Asp  Glu Glu Glu Arg Asn  Glu Thr Glu Gly Gln  Ile Asp Arg 
    1010                 1015                 1020             


Leu 
    


<210>  3147
<211>  1024
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3147

Met Ala Lys Lys Ile Thr Ala Lys Gln Arg Arg Glu Glu Arg Glu Arg 
1               5                   10                  15      


Gln Asn Lys Gln Lys Trp Ala Lys Lys Gln Asp Asp Ala Thr Ala Val 
            20                  25                  30          


Phe Glu Cys Glu Ala Asp Ile Lys Pro Ala Asp Ser Lys Asp Glu Asp 
        35                  40                  45              


Cys Ala Asn Thr Ser Ile Lys Arg Glu Lys Lys Lys Thr Gln Ala Lys 
    50                  55                  60                  


Ala Met Gly Leu Lys Thr Val Leu Gly Phe Asp Asn Lys Ile Ala Ile 
65                  70                  75                  80  


Ala Ser Phe Thr Ser Ser Lys Asp Ser Lys Ser Ser His Ile Glu Arg 
                85                  90                  95      


Ile Thr Asp Pro Asn Gly Lys Thr Ile Arg Glu Asp Val Arg Met Phe 
            100                 105                 110         


Asp Ser Asn Val Asp Glu Cys Ser Ile Asn Leu Glu Lys Arg Met Thr 
        115                 120                 125             


Val Glu Glu Arg Gln Lys Asp Gly Thr Ile Lys Lys Asp Glu Lys Asp 
    130                 135                 140                 


Val Lys Ser Thr Ile Cys Asn Pro Tyr Ser Asn Glu Cys Gly Lys Asp 
145                 150                 155                 160 


Tyr Ile Gly Ile Lys Ser Val Ala Glu Glu Leu Phe Phe Gly Arg Thr 
                165                 170                 175     


Phe Pro Asn Asp Asn Leu Arg Val Gln Ile Ala Tyr Asn Ile Phe Asp 
            180                 185                 190         


Ile Gln Lys Ile Phe Gly Thr Tyr Ile Asn Asn Ile Ile Tyr Ser Phe 
        195                 200                 205             


Tyr Asn Leu Ser Arg Asp Glu Phe Gln Ser Asp Asn Asp Val Ile Gly 
    210                 215                 220                 


Thr Leu Tyr Met Leu Lys Asp Phe Asp Gly Gln Lys Glu Thr Asp Thr 
225                 230                 235                 240 


Phe Arg Gln Ala Lys Ala Leu Leu Glu Arg Thr Glu Ala Tyr Tyr Ser 
                245                 250                 255     


Tyr Phe Asp Asn Val Phe Lys Lys Ile Asp Lys Lys Lys Lys Arg Asn 
            260                 265                 270         


Asp Asp Tyr Glu Gly Glu Arg Asn Glu Ile Leu Arg Tyr Asn Phe Asn 
        275                 280                 285             


Val Leu Arg Val Leu Ser Phe Leu Arg Gln Ile Cys Ala His Ala Lys 
    290                 295                 300                 


Val Lys Val Ser Ser Asp Asn Asp Arg Glu Lys Gly Gly Val Phe Val 
305                 310                 315                 320 


Asp Ser Leu Asp Ala Leu Phe Asn Ile Ser Arg Phe Phe Asp Ala Val 
                325                 330                 335     


Ala Pro Glu Leu Asn Glu Val Ile Asn Ser Val Tyr Ser Lys Gly Ile 
            340                 345                 350         


Asp Asp Ile Asn Asp Asn Phe Val Lys Asn Gly Lys Asn Asn Phe Tyr 
        355                 360                 365             


Ile Leu Ser Lys Ile Tyr Pro Glu Val Ala Arg Glu Asp Leu Leu Lys 
    370                 375                 380                 


Glu Tyr Tyr Tyr Phe Val Val Ser Lys Glu Gly Asn Asn Ile Gly Ile 
385                 390                 395                 400 


Ser Thr Lys Lys Leu Lys Glu Ala Ile Ile Ala Gln Asp Met Ser Tyr 
                405                 410                 415     


Ile Lys Ser Lys Asp Tyr Asp Thr Tyr Arg Asn Lys Leu Tyr Thr Val 
            420                 425                 430         


Leu Cys Phe Ile Leu Val Lys Glu Leu Asn Glu Arg Thr Thr Ile Arg 
        435                 440                 445             


Glu Gln Met Val Ala Asp Leu Arg Ala Asn Met Asn Gly Asp Ile Gly 
    450                 455                 460                 


Arg Glu Asp Ile Tyr Ser Lys Tyr Ala Lys Ile Ile Tyr Ala Gln Val 
465                 470                 475                 480 


Lys Pro Arg Phe Asp Ala Met Lys Asn Val Phe Glu Glu Glu Ala Lys 
                485                 490                 495     


Gly Val Ile Val Pro Asp Lys Glu Asp Thr Val Lys Phe Ser Asn Gly 
            500                 505                 510         


Ala Leu Asp Lys Ser Glu Ile Glu Arg Phe Cys Ile Thr Ser Ala Asn 
        515                 520                 525             


Thr Asp Ser Val Ala Lys Ile Ile Tyr Phe Leu Cys Lys Phe Leu Asp 
    530                 535                 540                 


Gly Lys Glu Ile Asn Glu Leu Cys Cys Ala Met Met Asn Lys Leu Asp 
545                 550                 555                 560 


Gly Ile Asn Asp Leu Ile Glu Thr Ala Glu Gln Cys Gly Ala Lys Ile 
                565                 570                 575     


Glu Phe Val Asp Asn Phe Asn Val Leu Ser Lys Cys Glu Thr Ile Ser 
            580                 585                 590         


Asp Gln Ile Arg Ile Val Lys Ser Ile Ser Lys Met Lys Lys Glu Ile 
        595                 600                 605             


Asp Val Asp Asn Glu Thr Ile Phe Phe Asp Ala Phe Glu Leu Leu Gly 
    610                 615                 620                 


Lys Arg Ile Glu Lys Tyr Lys Lys Asp Asp Ser Gly Asn Val Leu Arg 
625                 630                 635                 640 


Asn Asp Asp Gly Lys Val Leu Arg Thr Lys Glu Tyr Asn Asn Ile Arg 
                645                 650                 655     


Lys Met Leu Cys Lys Lys Asp Arg Arg Leu Asn Phe Ile Thr Asn Ser 
            660                 665                 670         


Ile Ile Lys Ser Lys Trp Phe Ser Tyr Ile Val Arg Tyr Asn Gln Pro 
        675                 680                 685             


Ser Glu Cys Gln Ala Ile Met Lys Asn Lys Thr Leu Val Lys Phe Ala 
    690                 695                 700                 


Leu Asp Glu Leu Pro Asp Leu Gln Ile Gln Arg Tyr Phe Val Ala Leu 
705                 710                 715                 720 


Tyr Gly Asp Glu Asp Leu Pro Ser Tyr Gly Glu Met Arg Lys Ile Leu 
                725                 730                 735     


Leu Lys Lys Leu His Asp Phe Ser Ile Arg Asp Phe Asp Glu Glu Ile 
            740                 745                 750         


Gly Ser Leu Phe Asp Glu Met Lys Arg Lys Asp Lys Phe Cys Glu Ser 
        755                 760                 765             


Asp Arg Lys Lys Cys Leu Phe Arg Leu Tyr Leu Thr Ile Ala Tyr Leu 
    770                 775                 780                 


Ile Thr Lys Ser Met Val Lys Ile Asn Thr Arg Phe Ser Ile Ala Cys 
785                 790                 795                 800 


Ala Thr Tyr Glu Arg Asp Tyr Ala Leu Leu Cys Ala Ser Asn Lys Gln 
                805                 810                 815     


Glu Arg Ala Trp Ser Ser Gly Ala Thr Ala Leu Ala Leu Thr Arg Lys 
            820                 825                 830         


Phe Leu Asn Gln Asp Lys Leu Ile Phe Glu Lys His Tyr Ala Arg Glu 
        835                 840                 845             


Gly Glu Ile Ser Lys Leu Pro Lys Glu Glu Arg Lys Ala Met Arg Lys 
    850                 855                 860                 


Val Asn Asp Gln Leu Leu Lys Gln Thr His Phe Ser Lys His Ser Tyr 
865                 870                 875                 880 


Cys Tyr Ile Val Asp Asn Val Asn Arg Leu Thr Gly Gly Glu Cys Arg 
                885                 890                 895     


Thr Asp Lys Arg Val Leu Pro Val Leu Asn Glu Lys Asn Asp Asn Ala 
            900                 905                 910         


Gly Ile Leu Pro Asp Phe Arg Lys Thr Ile Ala His Leu Asn Val Val 
        915                 920                 925             


His Lys Met Val Asp Tyr Val Gly Glu Ile Lys Gly Ile Thr Ser Tyr 
    930                 935                 940                 


Tyr Ala Phe Phe Cys Tyr Val Leu Gln Arg Met Pro Val Gly Asn Lys 
945                 950                 955                 960 


Asn Glu Lys Asn Ala Leu Lys Glu Lys Tyr Ser Glu Thr Ala Lys Ser 
                965                 970                 975     


Phe Gly Thr Tyr Ser Lys Asp Phe Met Trp Leu Ile Asn Leu Pro Phe 
            980                 985                 990         


Ala Tyr Asn Leu Pro Arg Tyr Lys  Asn Leu Ser Asn Glu  Gln Leu Phe 
        995                 1000                 1005             


Tyr Asp  Glu Glu Glu Arg Asn  Glu Thr Glu Gly Gln  Ile Asp Arg 
    1010                 1015                 1020             


Leu 
    


<210>  3148
<211>  954
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3148

Met Gly Lys Lys Ile His Ala Arg Asp Leu Arg Glu Gln Arg Lys Thr 
1               5                   10                  15      


Asp Arg Thr Glu Lys Phe Ala Asp Gln Asn Lys Lys Arg Glu Ala Glu 
            20                  25                  30          


Arg Ala Val Gln Lys Lys Asp Ala Ala Val Ser Val Lys Ser Val Ser 
        35                  40                  45              


Ser Val Ser Ser Lys Lys Asp Asn Val Thr Lys Ser Met Ala Lys Ala 
    50                  55                  60                  


Ala Gly Val Lys Ser Val Phe Ala Val Gly Asn Thr Val Tyr Met Thr 
65                  70                  75                  80  


Ser Phe Gly Arg Gly Asn Asp Ala Val Leu Glu Gln Lys Ile Val Asp 
                85                  90                  95      


Thr Ser His Glu Pro Leu Asn Ile Asp Asp Pro Ala Tyr Gln Leu Asn 
            100                 105                 110         


Val Val Thr Met Asn Gly Tyr Ser Val Thr Gly His Arg Gly Glu Thr 
        115                 120                 125             


Val Ser Ala Val Thr Asp Asn Pro Leu Arg Arg Phe Asn Gly Gly Lys 
    130                 135                 140                 


Lys Asp Glu Pro Glu Gln Ser Val Pro Thr Asp Met Leu Cys Leu Lys 
145                 150                 155                 160 


Pro Thr Leu Glu Lys Lys Phe Phe Gly Lys Glu Phe Asn Asp Asn Ile 
                165                 170                 175     


His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala 
            180                 185                 190         


Val Tyr Ser Thr Asn Ala Ile Tyr Ala Leu Asn Asn Met Ser Ala Asp 
        195                 200                 205             


Glu Asn Ile Glu Asn Ser Asp Phe Phe Met Lys Arg Thr Thr Asp Glu 
    210                 215                 220                 


Thr Phe Asp Asp Phe Glu Lys Lys Lys Glu Ser Thr Asn Ser Arg Glu 
225                 230                 235                 240 


Lys Ala Asp Phe Asp Ala Phe Glu Lys Phe Ile Gly Asn Tyr Arg Leu 
                245                 250                 255     


Ala Tyr Phe Ala Asp Ala Phe Tyr Val Asn Lys Lys Asn Pro Lys Gly 
            260                 265                 270         


Lys Ala Arg Asn Val Leu Arg Glu Asp Lys Glu Leu Tyr Ser Val Leu 
        275                 280                 285             


Thr Leu Ile Gly Lys Leu Arg His Trp Cys Val His Ser Glu Glu Gly 
    290                 295                 300                 


Arg Ala Glu Phe Trp Leu Tyr Lys Leu Asp Glu Leu Lys Asp Asp Phe 
305                 310                 315                 320 


Lys Asn Val Leu Asp Val Val Tyr Asn Arg Pro Val Glu Glu Ile Asn 
                325                 330                 335     


Asn Arg Phe Ile Glu Asn Asn Lys Val Asn Ile Gln Ile Leu Gly Ser 
            340                 345                 350         


Val Tyr Lys Asn Thr Asp Ile Ala Glu Leu Val Arg Ser Tyr Tyr Glu 
        355                 360                 365             


Phe Leu Ile Thr Lys Lys Tyr Lys Asn Met Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Ser Met Leu Glu Gly Lys Gly Tyr Ala Asp Lys Glu Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Asn Lys Leu Tyr Gln Met Thr Asp Phe Ile Leu Tyr 
                405                 410                 415     


Thr Gly Tyr Ile Asn Glu Asp Ser Asp Arg Ala Asp Asp Leu Val Asn 
            420                 425                 430         


Thr Leu Arg Ser Ser Leu Lys Glu Asp Asp Lys Thr Thr Val Tyr Cys 
        435                 440                 445             


Lys Glu Ala Asp Tyr Leu Trp Lys Lys Tyr Arg Glu Ser Ile Arg Glu 
    450                 455                 460                 


Val Ala Asp Ala Leu Asp Gly Asp Asn Ile Lys Arg Leu Ser Lys Ser 
465                 470                 475                 480 


Asn Ile Glu Ile Gln Glu Asp Lys Leu Arg Lys Cys Phe Ile Ser Tyr 
                485                 490                 495     


Ala Asp Ser Val Ser Glu Phe Thr Lys Leu Ile Tyr Leu Leu Thr Arg 
            500                 505                 510         


Phe Leu Ser Gly Lys Glu Ile Asn Asp Leu Val Thr Thr Leu Ile Asn 
        515                 520                 525             


Lys Phe Asp Asn Ile Arg Ser Phe Leu Glu Ile Met Asp Glu Leu Gly 
    530                 535                 540                 


Leu Asp Arg Thr Phe Thr Ala Glu Tyr Ser Phe Phe Glu Gly Ser Thr 
545                 550                 555                 560 


Lys Tyr Leu Ala Glu Leu Val Glu Leu Asn Ser Phe Val Lys Ser Cys 
                565                 570                 575     


Ser Phe Asp Ile Asn Ala Lys Arg Thr Met Tyr Arg Asp Ala Leu Asp 
            580                 585                 590         


Ile Leu Gly Ile Lys Ser Gly Lys Thr Glu Glu Asp Ile Glu Lys Met 
        595                 600                 605             


Ile Asp Asn Ile Leu Gln Ile Asp Ala Asn Gly Asp Lys Lys Leu Lys 
    610                 615                 620                 


Lys Asn Asn Gly Leu Arg Asn Phe Ile Ala Ser Asn Val Ile Asp Ser 
625                 630                 635                 640 


Asn Arg Phe Lys Tyr Leu Val Arg Tyr Gly Asn Pro Lys Lys Ile Arg 
                645                 650                 655     


Glu Thr Ala Lys Cys Lys Pro Ala Val Arg Phe Val Leu Asn Glu Ile 
            660                 665                 670         


Pro Asp Ala Gln Ile Glu Arg Tyr Tyr Glu Ala Cys Cys Pro Lys Asn 
        675                 680                 685             


Thr Ala Leu Cys Ser Ala Asn Lys Arg Arg Glu Lys Leu Ala Asp Met 
    690                 695                 700                 


Ile Ala Glu Ile Glu Phe Glu Asn Phe Ser Asp Ala Gly Asn Tyr Gln 
705                 710                 715                 720 


Lys Ala Asn Val Thr Ser Arg Thr Ser Glu Ala Glu Ile Lys Arg Lys 
                725                 730                 735     


Asn Gln Ala Ile Ile Arg Leu Tyr Leu Thr Val Met Tyr Ile Met Leu 
            740                 745                 750         


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Phe His Cys 
        755                 760                 765             


Val Glu Arg Asp Thr Lys Leu Tyr Ala Glu Ser Gly Leu Glu Val Gly 
    770                 775                 780                 


Asn Ile Glu Lys Asn Lys Thr Asn Leu Thr Met Ala Val Met Gly Val 
785                 790                 795                 800 


Lys Leu Glu Asn Gly Ile Ile Lys Thr Glu Phe Asp Lys Ser Leu Ala 
                805                 810                 815     


Glu Asn Ala Ala Asn Arg Tyr Leu Arg Asn Ala Arg Trp Tyr Lys Leu 
            820                 825                 830         


Ile Leu Asp Asn Leu Lys Lys Ser Glu Arg Ala Val Val Asn Glu Phe 
        835                 840                 845             


Arg Asn Thr Val Cys His Leu Asn Ala Ile Arg Asn Ile Asn Ile Asn 
    850                 855                 860                 


Ile Lys Glu Ile Lys Glu Val Glu Asn Tyr Phe Ala Leu Tyr His Tyr 
865                 870                 875                 880 


Leu Ile Gln Lys His Leu Glu Asn Arg Phe Ala Asp Lys Lys Val Glu 
                885                 890                 895     


Arg Asp Thr Gly Asp Phe Ile Ser Lys Leu Glu Glu His Lys Thr Tyr 
            900                 905                 910         


Cys Lys Asp Phe Val Lys Ala Tyr Cys Thr Pro Phe Gly Tyr Asn Leu 
        915                 920                 925             


Val Arg Tyr Lys Asn Leu Thr Ile Asp Gly Leu Phe Asp Lys Asn Tyr 
    930                 935                 940                 


Pro Arg Lys Asp Asp Ser Asp Lys Gln Lys 
945                 950                 


<210>  3149
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3149

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Asp Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Lys 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Leu Glu Asn Glu Ser Asn Asn Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe Thr Asp Pro 
    210                 215                 220                 


Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn Ile Lys Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu Tyr Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Ile Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Asp Asp Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Ile Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Arg Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3150
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3150

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Gly Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asp Asn Asp Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Glu Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Ala Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Cys Val Phe His Asp Leu Ser Glu His Ser Glu Tyr 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Asn Ser Lys Lys Val Tyr Arg Glu Cys 
305                 310                 315                 320 


Arg Glu Thr Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn 
                325                 330                 335     


Lys Gly Phe Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp 
            340                 345                 350         


Met Met Lys Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp 
        355                 360                 365             


Phe Ile Val Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys 
385                 390                 395                 400 


Gln Tyr Asp Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu 
                405                 410                 415     


Leu Phe Cys Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu 
            420                 425                 430         


Val Arg Lys Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Thr 
        435                 440                 445             


Tyr Ala Asp Glu Ala Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe 
    450                 455                 460                 


Glu Asn Ile Ala Asp His Met Asn Gly Asp Ala Ile Lys Glu Leu Gly 
465                 470                 475                 480 


Lys Ala Asp Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys 
                485                 490                 495     


Asn Ala Ser Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr 
            500                 505                 510         


Tyr Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile 
        515                 520                 525             


Ser Lys Phe Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser 
    530                 535                 540                 


Ala Val Asp Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn 
545                 550                 555                 560 


Asp Ser Gln Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala 
                565                 570                 575     


Ser Met Arg Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp 
            580                 585                 590         


Ala Leu Thr Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile 
        595                 600                 605             


Ser Glu Ile Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu 
    610                 615                 620                 


Arg Asn Phe Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr 
625                 630                 635                 640 


Leu Ile Lys Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn 
                645                 650                 655     


Glu Lys Val Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile 
            660                 665                 670         


Glu Arg Tyr Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser 
        675                 680                 685             


Leu Glu Ala Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser 
    690                 695                 700                 


Phe Asp Asp Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn 
705                 710                 715                 720 


Val Ala Lys Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val 
                725                 730                 735     


Met Tyr Leu Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val 
            740                 745                 750         


Ile Ala Ile His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile 
        755                 760                 765             


Ile Pro Glu Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu 
    770                 775                 780                 


Ser Gln Thr Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  3151
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3151

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Ile Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Pro Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn His Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3152
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3152

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Gln Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Trp Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Ser Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asp Asp Lys Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  3153
<211>  1024
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3153

Met Ala Lys Lys Ile Thr Ala Lys Gln Arg Arg Glu Glu Arg Glu Arg 
1               5                   10                  15      


Gln Asn Lys Gln Lys Trp Ala Lys Lys Gln Asp Asp Ala Thr Ala Val 
            20                  25                  30          


Phe Glu Cys Glu Ala Asp Ile Lys Pro Ala Asp Ser Lys Asp Glu Asp 
        35                  40                  45              


Cys Ala Asn Thr Ser Ile Lys Arg Glu Lys Lys Lys Thr Gln Ala Lys 
    50                  55                  60                  


Ala Met Gly Leu Lys Thr Val Leu Gly Phe Asp Asn Lys Ile Ala Ile 
65                  70                  75                  80  


Ala Ser Phe Thr Ser Ser Lys Asp Ser Lys Ser Ser His Ile Glu Arg 
                85                  90                  95      


Ile Thr Asp Pro Asn Gly Lys Thr Ile Arg Glu Asp Val Arg Met Phe 
            100                 105                 110         


Asp Ser Asn Val Asp Glu Cys Ser Ile Asn Leu Glu Lys Arg Met Thr 
        115                 120                 125             


Val Glu Glu Arg Gln Lys Asp Gly Thr Ile Lys Lys Asp Glu Lys Asp 
    130                 135                 140                 


Val Lys Ser Thr Ile Cys Asn Pro Tyr Ser Asn Glu Cys Gly Lys Asp 
145                 150                 155                 160 


Tyr Ile Gly Ile Lys Ser Val Ala Glu Glu Leu Phe Phe Gly Arg Thr 
                165                 170                 175     


Phe Pro Asn Asp Asn Leu Arg Val Gln Ile Ala Tyr Asn Ile Phe Asp 
            180                 185                 190         


Ile Gln Lys Ile Phe Gly Thr Tyr Ile Asn Asn Ile Ile Tyr Ser Phe 
        195                 200                 205             


Tyr Asn Leu Ser Arg Asp Glu Phe Gln Ser Asp Asn Asp Val Ile Gly 
    210                 215                 220                 


Thr Leu Tyr Met Leu Lys Asp Phe Asp Gly Gln Lys Glu Thr Asp Thr 
225                 230                 235                 240 


Phe Arg Gln Ala Lys Ala Leu Leu Glu Arg Thr Glu Ala Tyr Tyr Ser 
                245                 250                 255     


Tyr Phe Asp Asn Val Phe Lys Lys Ile Asp Lys Lys Lys Lys Arg Asn 
            260                 265                 270         


Asp Asp Tyr Glu Gly Glu Arg Asn Glu Ile Leu Arg Tyr Asn Phe Asn 
        275                 280                 285             


Val Leu Arg Val Leu Ser Phe Leu Arg Gln Ile Cys Ala His Ala Lys 
    290                 295                 300                 


Val Lys Val Ser Ser Asp Asn Asp Arg Glu Lys Gly Gly Val Phe Val 
305                 310                 315                 320 


Asp Ser Leu Asp Ala Leu Phe Asn Ile Ser Arg Phe Phe Asp Ala Val 
                325                 330                 335     


Ala Pro Glu Leu Asn Glu Val Ile Asn Ser Val Tyr Ser Lys Gly Ile 
            340                 345                 350         


Asp Asp Ile Asn Asp Asn Phe Val Lys Asn Gly Lys Asn Asn Phe Tyr 
        355                 360                 365             


Ile Leu Ser Lys Ile Tyr Pro Glu Val Ala Arg Glu Asp Leu Leu Lys 
    370                 375                 380                 


Glu Tyr Tyr Tyr Phe Val Val Ser Lys Glu Gly Asn Asn Ile Gly Ile 
385                 390                 395                 400 


Ser Thr Lys Lys Leu Lys Glu Ala Ile Ile Ala Gln Asp Met Ser Tyr 
                405                 410                 415     


Ile Lys Ser Lys Asp Tyr Asp Thr Tyr Arg Asn Lys Leu Tyr Thr Val 
            420                 425                 430         


Leu Cys Phe Ile Leu Val Lys Glu Leu Asn Glu Arg Thr Thr Ile Arg 
        435                 440                 445             


Glu Gln Met Val Ala Asp Leu Arg Ala Asn Met Asn Gly Asp Ile Gly 
    450                 455                 460                 


Arg Glu Asp Ile Tyr Ser Lys Tyr Ala Lys Ile Ile Tyr Ala Gln Val 
465                 470                 475                 480 


Lys Pro Arg Phe Asp Ala Met Lys Asn Val Phe Glu Glu Glu Ala Lys 
                485                 490                 495     


Gly Val Ile Val Pro Asp Lys Glu Asp Thr Val Lys Phe Ser Asn Gly 
            500                 505                 510         


Ala Leu Asp Lys Ser Glu Ile Glu Arg Phe Cys Ile Thr Ser Ala Asn 
        515                 520                 525             


Thr Asp Ser Val Ala Lys Ile Ile Tyr Phe Leu Cys Lys Phe Leu Asp 
    530                 535                 540                 


Gly Lys Glu Ile Asn Glu Leu Cys Cys Ala Met Met Asn Lys Leu Asp 
545                 550                 555                 560 


Gly Ile Asn Asp Leu Ile Glu Thr Ala Glu Gln Cys Gly Ala Lys Ile 
                565                 570                 575     


Glu Phe Val Asp Asn Phe Asn Val Leu Ser Lys Cys Glu Thr Ile Ser 
            580                 585                 590         


Asp Gln Ile Arg Ile Val Lys Ser Ile Ser Lys Met Lys Lys Glu Ile 
        595                 600                 605             


Asp Val Asp Asn Glu Thr Ile Phe Phe Asp Ala Phe Glu Leu Leu Gly 
    610                 615                 620                 


Lys Arg Ile Glu Lys Tyr Lys Lys Asp Asp Ser Gly Asn Val Leu Arg 
625                 630                 635                 640 


Asn Asp Asp Gly Lys Val Leu Arg Thr Lys Glu Tyr Asn Asn Ile Arg 
                645                 650                 655     


Lys Met Leu Cys Lys Lys Asp Arg Arg Leu Asn Phe Ile Thr Asn Ser 
            660                 665                 670         


Ile Ile Lys Ser Lys Trp Phe Ser Tyr Ile Val Arg Tyr Asn Gln Pro 
        675                 680                 685             


Ser Glu Cys Gln Ala Ile Met Lys Asn Lys Thr Leu Val Lys Phe Ala 
    690                 695                 700                 


Leu Asp Glu Leu Pro Asp Leu Gln Ile Gln Arg Tyr Phe Val Ala Leu 
705                 710                 715                 720 


Tyr Gly Asp Glu Asp Leu Pro Ser Tyr Gly Glu Met Arg Lys Ile Leu 
                725                 730                 735     


Leu Lys Lys Leu His Asp Phe Ser Ile Arg Asp Phe Asp Glu Glu Ile 
            740                 745                 750         


Gly Ser Leu Phe Asp Glu Met Lys Arg Lys Asp Lys Phe Cys Glu Ser 
        755                 760                 765             


Asp Arg Lys Lys Cys Leu Phe Arg Leu Tyr Leu Thr Ile Ala Tyr Leu 
    770                 775                 780                 


Ile Thr Lys Ser Met Val Lys Ile Asn Thr Arg Phe Ser Ile Ala Cys 
785                 790                 795                 800 


Ala Thr Tyr Glu Arg Asp Tyr Ala Leu Leu Cys Ala Ser Asn Lys Gln 
                805                 810                 815     


Glu Arg Ala Trp Ser Ser Gly Ala Thr Ala Leu Ala Leu Thr Arg Lys 
            820                 825                 830         


Phe Leu Asn Gln Asp Lys Leu Ile Phe Glu Lys His Tyr Ala Arg Glu 
        835                 840                 845             


Gly Glu Ile Ser Lys Leu Pro Lys Glu Glu Arg Lys Ala Met Arg Lys 
    850                 855                 860                 


Val Asn Asp Gln Leu Leu Lys Gln Thr His Phe Ser Lys His Ser Tyr 
865                 870                 875                 880 


Cys Tyr Ile Val Asp Asn Val Asn Arg Leu Thr Gly Gly Glu Cys Arg 
                885                 890                 895     


Thr Asp Lys Arg Val Leu Pro Val Leu Asn Glu Lys Asn Asp Asn Ala 
            900                 905                 910         


Gly Ile Leu Pro Asp Phe Arg Lys Thr Ile Ala His Leu Asn Val Val 
        915                 920                 925             


His Lys Met Val Asp Tyr Val Gly Glu Ile Lys Gly Ile Thr Ser Tyr 
    930                 935                 940                 


Tyr Ala Phe Phe Cys Tyr Val Leu Gln Arg Met Pro Val Gly Asn Lys 
945                 950                 955                 960 


Asn Glu Lys Asn Ala Leu Lys Glu Lys Tyr Ser Glu Thr Ala Lys Ser 
                965                 970                 975     


Phe Gly Thr Tyr Ser Lys Asp Phe Met Trp Leu Ile Asn Leu Pro Phe 
            980                 985                 990         


Ala Tyr Asn Leu Pro Arg Tyr Lys  Asn Leu Ser Asn Glu  Gln Leu Phe 
        995                 1000                 1005             


Tyr Asp  Glu Glu Glu Arg Asn  Glu Thr Glu Gly Gln  Ile Asp Arg 
    1010                 1015                 1020             


Leu 
    


<210>  3154
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3154

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Thr 
            20                  25                  30          


Pro Thr Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Lys Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asn Ser Ser Asn Ile Glu Leu Arg Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Lys Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Glu Ala Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Gly Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3155
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3155

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asp Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asn Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Lys Lys Gln Glu Glu Lys Ile Lys Phe Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3156
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3156

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Lys Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Met Lys 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Ile Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Asn Arg Val Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Arg Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3157
<211>  928
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3157

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Gly 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys Arg Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Glu Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Ala Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Cys Val Phe His Asp Leu Ser Glu His Ser Glu Tyr 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Asn Ser Lys Lys Val Tyr Arg Glu Cys 
305                 310                 315                 320 


Arg Glu Thr Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn 
                325                 330                 335     


Lys Gly Phe Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp 
            340                 345                 350         


Met Met Lys Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp 
        355                 360                 365             


Phe Ile Val Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys 
385                 390                 395                 400 


Gln Tyr Asp Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu 
                405                 410                 415     


Leu Phe Cys Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu 
            420                 425                 430         


Val Arg Lys Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile 
        435                 440                 445             


Tyr Ala Asp Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe 
    450                 455                 460                 


Glu Asn Ile Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly 
465                 470                 475                 480 


Lys Ala Asp Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys 
                485                 490                 495     


Asn Ala Ser Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr 
            500                 505                 510         


Tyr Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile 
        515                 520                 525             


Ser Lys Phe Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser 
    530                 535                 540                 


Ala Val Asp Val Glu Cys Glu Leu Thr Val Gly Tyr Lys Leu Phe Asn 
545                 550                 555                 560 


Asp Ser Gln Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala 
                565                 570                 575     


Ser Met Arg Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp 
            580                 585                 590         


Ala Leu Ala Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile 
        595                 600                 605             


Ser Glu Ile Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu 
    610                 615                 620                 


Arg Asn Phe Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr 
625                 630                 635                 640 


Leu Ile Lys Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn 
                645                 650                 655     


Glu Lys Val Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile 
            660                 665                 670         


Glu Arg Tyr Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser 
        675                 680                 685             


Leu Glu Ala Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser 
    690                 695                 700                 


Phe Asp Asp Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn 
705                 710                 715                 720 


Val Ala Lys Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val 
                725                 730                 735     


Met Tyr Leu Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val 
            740                 745                 750         


Ile Ala Ile His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile 
        755                 760                 765             


Ile Pro Glu Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu 
    770                 775                 780                 


Ser Gln Thr Leu Cys Glu Leu Cys Asp Asp Arg Asp Lys Ser Pro Asn 
785                 790                 795                 800 


Leu Phe Leu Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp 
                805                 810                 815     


Ile Asn Asn Ala Asp Ser Ile Met Thr Arg Lys Tyr Arg Asn Cys Ile 
            820                 825                 830         


Ala His Leu Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile 
        835                 840                 845             


Arg Thr Val Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg 
    850                 855                 860                 


Cys Ile Thr Lys Arg Glu Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys 
865                 870                 875                 880 


Tyr Glu Asp Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val 
                885                 890                 895     


Lys Ala Leu Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn 
            900                 905                 910         


Leu Ser Ile Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925             


<210>  3158
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3158

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Thr 
            20                  25                  30          


Pro Thr Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Lys Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asn Ser Ser Asn Ile Glu Leu Arg Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Lys Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Glu Ala Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Gly Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3159
<211>  918
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3159

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Gly Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Asn Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp 
    370                 375                 380                 


Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Gly Val Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ser Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu Arg 
785                 790                 795                 800 


Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr Arg 
                805                 810                 815     


Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu Lys 
            820                 825                 830         


Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile Tyr 
        835                 840                 845             


His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp Asp Thr Lys 
    850                 855                 860                 


Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His Gly 
865                 870                 875                 880 


Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr Asn 
                885                 890                 895     


Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg Asn 
            900                 905                 910         


Glu Tyr Leu Thr Glu Lys 
        915             


<210>  3160
<211>  921
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3160

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Lys Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asp Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asn 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Gly Ser Glu Ser 
        195                 200                 205             


Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe 
    210                 215                 220                 


Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile 
225                 230                 235                 240 


Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu 
                245                 250                 255     


Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser 
            260                 265                 270         


Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln 
        275                 280                 285             


Ile Arg Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp 
    290                 295                 300                 


Leu Tyr Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu 
305                 310                 315                 320 


Asp Tyr Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile 
                325                 330                 335     


Glu Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly 
            340                 345                 350         


Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu 
        355                 360                 365             


Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys 
    370                 375                 380                 


Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser 
385                 390                 395                 400 


Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn 
                405                 410                 415     


Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu 
            420                 425                 430         


Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu 
        435                 440                 445             


Ala Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala 
    450                 455                 460                 


Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met 
465                 470                 475                 480 


Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp 
                485                 490                 495     


Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp 
            500                 505                 510         


Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp 
        515                 520                 525             


Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn Val 
    530                 535                 540                 


Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg 
545                 550                 555                 560 


Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys 
                565                 570                 575     


Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile 
            580                 585                 590         


Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu 
        595                 600                 605             


Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile 
    610                 615                 620                 


Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr 
625                 630                 635                 640 


Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val 
                645                 650                 655     


Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr 
            660                 665                 670         


Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys 
        675                 680                 685             


Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe 
    690                 695                 700                 


Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu 
705                 710                 715                 720 


Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu 
                725                 730                 735     


Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His 
            740                 745                 750         


Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu 
        755                 760                 765             


Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu 
    770                 775                 780                 


Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Lys 
785                 790                 795                 800 


Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser 
                805                 810                 815     


Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg 
            820                 825                 830         


Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe 
        835                 840                 845             


Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn 
    850                 855                 860                 


Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys 
865                 870                 875                 880 


Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe 
                885                 890                 895     


Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe 
            900                 905                 910         


Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920     


<210>  3161
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3161

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Met Lys 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Ile Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Asn Arg Val Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3162
<211>  923
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3162

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Val Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Glu Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asn Ser Ser Asn Ile Glu Leu Arg Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Gly Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu His Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Asp Asp Tyr 
            340                 345                 350         


Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys 
        355                 360                 365             


Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met 
    370                 375                 380                 


Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val 
385                 390                 395                 400 


Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr 
                405                 410                 415     


Tyr Arg Asn Asp Val Ile Ala Gly Glu Ala Leu Val Arg Lys Leu Arg 
            420                 425                 430         


Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala 
        435                 440                 445             


Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp 
    450                 455                 460                 


His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp 
465                 470                 475                 480 


Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu 
                485                 490                 495     


Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly 
            500                 505                 510         


Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn 
        515                 520                 525             


Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu 
    530                 535                 540                 


Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile 
545                 550                 555                 560 


Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro 
                565                 570                 575     


Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu 
            580                 585                 590         


Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys 
        595                 600                 605             


Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr 
    610                 615                 620                 


Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala 
625                 630                 635                 640 


Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met 
                645                 650                 655     


Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys 
            660                 665                 670         


Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg 
        675                 680                 685             


Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys 
    690                 695                 700                 


Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg 
705                 710                 715                 720 


Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val 
                725                 730                 735     


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys 
            740                 745                 750         


Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala 
        755                 760                 765             


Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys 
    770                 775                 780                 


Glu Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys 
785                 790                 795                 800 


Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp 
                805                 810                 815     


Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val 
            820                 825                 830         


Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser 
        835                 840                 845             


Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg 
    850                 855                 860                 


Glu Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu 
865                 870                 875                 880 


Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser 
                885                 890                 895     


Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln 
            900                 905                 910         


Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920             


<210>  3163
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3163

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asp Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Phe Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Lys Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Ala Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Leu Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr Tyr Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Leu Ser Glu His Ser Glu Tyr Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Asn Ser Lys Lys Val Tyr Arg Glu Cys Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ala Lys Leu Trp Val Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3164
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3164

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Phe 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Glu Asp Ser Ser Asn Ile Glu Leu Cys Gly Val Thr Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Leu Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Lys Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Ala Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Lys Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Lys 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Ile Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Glu 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Gln Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Ser Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Val Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asp Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp Asp Thr 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  3165
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3165

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Gln Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asn Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Glu Gly Ser Ser Asn Ile Glu Leu Arg Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Asp Glu Ser His Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe Thr Asp 
    210                 215                 220                 


Pro Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Asn Arg Val Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asn Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3166
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3166

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Ile Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Pro Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn His Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3167
<211>  954
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3167

Met Gly Lys Lys Ile His Ala Arg Asp Leu Arg Glu Gln Arg Lys Thr 
1               5                   10                  15      


Asp Arg Thr Glu Lys Phe Ala Asp Gln Asn Lys Lys Arg Glu Ala Glu 
            20                  25                  30          


Arg Ala Val Gln Lys Lys Asp Ala Ala Val Ser Val Lys Ser Val Ser 
        35                  40                  45              


Ser Val Ser Ser Lys Lys Asp Asn Val Thr Lys Ser Met Ala Lys Ala 
    50                  55                  60                  


Ala Gly Val Lys Ser Val Phe Ala Val Gly Asn Thr Val Tyr Met Thr 
65                  70                  75                  80  


Ser Phe Gly Arg Gly Asn Asp Ala Val Leu Glu Gln Lys Ile Val Asp 
                85                  90                  95      


Thr Ser His Glu Pro Leu Asn Ile Asp Asp Pro Ala Tyr Gln Leu Asn 
            100                 105                 110         


Val Val Thr Met Asn Gly Tyr Ser Val Thr Gly His Arg Gly Glu Thr 
        115                 120                 125             


Val Ser Ala Val Thr Asp Asn Pro Leu Arg Arg Phe Asn Gly Gly Lys 
    130                 135                 140                 


Lys Asp Glu Pro Glu Gln Ser Val Pro Thr Asp Met Leu Cys Leu Lys 
145                 150                 155                 160 


Pro Thr Leu Glu Lys Lys Phe Phe Gly Lys Glu Phe Asn Asp Asn Ile 
                165                 170                 175     


His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala 
            180                 185                 190         


Val Tyr Ser Thr Asn Ala Ile Tyr Ala Leu Asn Asn Met Ser Ala Asp 
        195                 200                 205             


Glu Asn Ile Glu Asn Ser Asp Phe Phe Met Lys Arg Thr Thr Asp Glu 
    210                 215                 220                 


Thr Phe Asp Asp Phe Glu Lys Lys Lys Glu Ser Thr Asn Ser Arg Glu 
225                 230                 235                 240 


Lys Ala Asp Phe Asp Ala Phe Glu Lys Phe Ile Gly Asn Tyr Arg Leu 
                245                 250                 255     


Ala Tyr Phe Ala Asp Ala Phe Tyr Val Asn Lys Lys Asn Pro Lys Gly 
            260                 265                 270         


Lys Ala Arg Asn Val Leu Arg Glu Asp Lys Glu Leu Tyr Ser Val Leu 
        275                 280                 285             


Thr Leu Ile Gly Lys Leu Arg His Trp Cys Val His Ser Glu Glu Gly 
    290                 295                 300                 


Arg Ala Glu Phe Trp Leu Tyr Lys Leu Asp Glu Leu Lys Asp Asp Phe 
305                 310                 315                 320 


Lys Asn Val Leu Asp Val Val Tyr Asn Arg Pro Val Glu Glu Ile Asn 
                325                 330                 335     


Asn Arg Phe Ile Glu Asn Asn Lys Val Asn Ile Gln Ile Leu Gly Ser 
            340                 345                 350         


Val Tyr Lys Asn Thr Asp Ile Ala Glu Leu Val Arg Ser Tyr Tyr Glu 
        355                 360                 365             


Phe Leu Ile Thr Lys Lys Tyr Lys Asn Met Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Ser Met Leu Glu Gly Lys Gly Tyr Ala Asp Lys Glu Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Asn Lys Leu Tyr Gln Met Thr Asp Phe Ile Leu Tyr 
                405                 410                 415     


Thr Gly Tyr Ile Asn Glu Asp Ser Asp Arg Ala Asp Asp Leu Val Asn 
            420                 425                 430         


Thr Leu Arg Ser Ser Leu Lys Glu Asp Asp Lys Thr Thr Val Tyr Cys 
        435                 440                 445             


Lys Glu Ala Asp Tyr Leu Trp Lys Lys Tyr Arg Glu Ser Ile Arg Glu 
    450                 455                 460                 


Val Ala Asp Ala Leu Asp Gly Asp Asn Ile Lys Arg Leu Ser Lys Ser 
465                 470                 475                 480 


Asn Ile Glu Ile Gln Glu Asp Lys Leu Arg Lys Cys Phe Ile Ser Tyr 
                485                 490                 495     


Ala Asp Ser Val Ser Glu Phe Thr Lys Leu Ile Tyr Leu Leu Thr Arg 
            500                 505                 510         


Phe Leu Ser Gly Lys Glu Ile Asn Asp Leu Val Thr Thr Leu Ile Asn 
        515                 520                 525             


Lys Phe Asp Asn Ile Arg Ser Phe Leu Glu Ile Met Asp Glu Leu Gly 
    530                 535                 540                 


Leu Asp Arg Thr Phe Thr Ala Glu Tyr Ser Phe Phe Glu Gly Ser Thr 
545                 550                 555                 560 


Lys Tyr Leu Ala Glu Leu Val Glu Leu Asn Ser Phe Val Lys Ser Cys 
                565                 570                 575     


Ser Phe Asp Ile Asn Ala Lys Arg Thr Met Tyr Arg Asp Ala Leu Asp 
            580                 585                 590         


Ile Leu Gly Ile Lys Ser Gly Lys Thr Glu Glu Asp Ile Glu Lys Met 
        595                 600                 605             


Ile Asp Asn Ile Leu Gln Ile Asp Ala Asn Gly Asp Lys Lys Leu Lys 
    610                 615                 620                 


Lys Asn Asn Gly Leu Arg Asn Phe Ile Ala Ser Asn Val Ile Asp Ser 
625                 630                 635                 640 


Asn Arg Phe Lys Tyr Leu Val Arg Tyr Gly Asn Pro Lys Lys Ile Arg 
                645                 650                 655     


Glu Thr Ala Lys Cys Lys Pro Ala Val Arg Phe Val Leu Asn Glu Ile 
            660                 665                 670         


Pro Asp Ala Gln Ile Glu Arg Tyr Tyr Glu Ala Cys Cys Pro Lys Asn 
        675                 680                 685             


Thr Ala Leu Cys Ser Ala Asn Lys Arg Arg Glu Lys Leu Ala Asp Met 
    690                 695                 700                 


Ile Ala Glu Ile Glu Phe Glu Asn Phe Ser Asp Ala Gly Asn Tyr Gln 
705                 710                 715                 720 


Lys Ala Asn Val Thr Ser Arg Thr Ser Glu Ala Glu Ile Lys Arg Lys 
                725                 730                 735     


Asn Gln Ala Ile Ile Arg Leu Tyr Leu Thr Val Met Tyr Ile Met Leu 
            740                 745                 750         


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Phe His Cys 
        755                 760                 765             


Val Glu Arg Asp Thr Lys Leu Tyr Ala Glu Ser Gly Leu Glu Val Gly 
    770                 775                 780                 


Asn Ile Glu Lys Asn Lys Thr Asn Leu Thr Met Ala Val Met Gly Val 
785                 790                 795                 800 


Lys Leu Glu Asn Gly Ile Ile Lys Thr Glu Phe Asp Lys Ser Leu Ala 
                805                 810                 815     


Glu Asn Ala Ala Asn Arg Tyr Leu Arg Asn Ala Arg Trp Tyr Lys Leu 
            820                 825                 830         


Ile Leu Asp Asn Leu Lys Lys Ser Glu Arg Ala Val Val Asn Glu Phe 
        835                 840                 845             


Arg Asn Thr Val Cys His Leu Asn Ala Ile Arg Asn Ile Asn Ile Asn 
    850                 855                 860                 


Ile Asp Gly Ile Lys Glu Val Glu Asn Tyr Phe Ala Leu Tyr His Tyr 
865                 870                 875                 880 


Leu Ile Gln Lys His Leu Glu Asn Arg Phe Ala Asp Lys Lys Val Glu 
                885                 890                 895     


Arg Asp Thr Gly Asp Phe Ile Ser Lys Leu Glu Glu His Lys Thr Tyr 
            900                 905                 910         


Cys Lys Asp Phe Val Lys Ala Tyr Cys Thr Pro Phe Gly Tyr Asn Leu 
        915                 920                 925             


Val Arg Tyr Lys Asn Leu Thr Ile Asp Gly Leu Phe Asp Lys Asn Tyr 
    930                 935                 940                 


Pro Gly Lys Asp Asp Ser Asp Glu Gln Lys 
945                 950                 


<210>  3168
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3168

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Lys Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Val 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys Arg Gly Asn Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser 
        195                 200                 205             


His Asp Asp Phe Ile Gly Tyr Leu Ser Thr Asn Asn Ile Tyr Asp Val 
    210                 215                 220                 


Phe Ile Asp Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn 
225                 230                 235                 240 


Val Arg Lys Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Asn Arg Val 
            260                 265                 270         


Ser Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Gly Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Lys Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3169
<211>  920
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3169

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Val Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Val Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asn Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Gly Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr Asn 
    210                 215                 220                 


Pro Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Val Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Asp Asp Tyr 
            340                 345                 350         


Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys 
        355                 360                 365             


Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met 
    370                 375                 380                 


Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val 
385                 390                 395                 400 


Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr 
                405                 410                 415     


Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg 
            420                 425                 430         


Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala 
        435                 440                 445             


Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp 
    450                 455                 460                 


His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp 
465                 470                 475                 480 


Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu 
                485                 490                 495     


Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly 
            500                 505                 510         


Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn 
        515                 520                 525             


Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu 
    530                 535                 540                 


Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile 
545                 550                 555                 560 


Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro 
                565                 570                 575     


Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu 
            580                 585                 590         


Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys 
        595                 600                 605             


Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr 
    610                 615                 620                 


Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala 
625                 630                 635                 640 


Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met 
                645                 650                 655     


Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys 
            660                 665                 670         


Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg 
        675                 680                 685             


Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Cys Phe Asp Asp Phe Lys 
    690                 695                 700                 


Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg 
705                 710                 715                 720 


Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val 
                725                 730                 735     


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys 
            740                 745                 750         


Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Val Ser Glu Leu Ala 
        755                 760                 765             


Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys 
    770                 775                 780                 


Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg 
785                 790                 795                 800 


Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met 
                805                 810                 815     


Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu 
            820                 825                 830         


Leu Lys Glu Tyr Ile Gly Asp Ile Arg Ala Val Asp Ser Tyr Phe Ser 
        835                 840                 845             


Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Gly Asn Asp 
    850                 855                 860                 


Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn 
865                 870                 875                 880 


His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly 
                885                 890                 895     


Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp 
            900                 905                 910         


Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920 


<210>  3170
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3170

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys Arg Gly Asn Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Lys Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Ala Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Thr Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Thr Tyr Ala Asp 
        435                 440                 445             


Glu Ala Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Ala Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3171
<211>  939
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3171

Met Ala Lys Lys Lys Arg Ile Thr Ala Lys Glu Arg Lys Gln Asn His 
1               5                   10                  15      


Arg Glu Ser Leu Met Lys Lys Ala Asp Ser Asn Ala Glu Lys Glu Lys 
            20                  25                  30          


Ala Lys Lys Pro Val Val Glu Asn Lys Pro Asp Thr Ala Ile Ser Lys 
        35                  40                  45              


Asp Asn Ile Pro Lys Pro Asn Lys Glu Ile Lys Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Ala Gly Val Lys Trp Val Ile Lys Ala Asn Asp Asp Val Ala Tyr 
65                  70                  75                  80  


Ile Ser Ser Phe Gly Lys Gly Asn Asn Ser Val Leu Glu Lys Arg Ile 
                85                  90                  95      


Met Gly Asp Val Ser Ser Asn Val Asn Lys Asp Ser His Met Tyr Val 
            100                 105                 110         


Asn Pro Lys Tyr Thr Lys Lys Asn Tyr Glu Ile Lys Asn Gly Phe Ser 
        115                 120                 125             


Ser Gly Ser Ser Leu Val Thr Tyr Pro Asn Lys Pro Asp Lys Asn Ser 
    130                 135                 140                 


Gly Met Asp Ala Leu Cys Leu Lys Pro Tyr Phe Glu Lys Asp Phe Phe 
145                 150                 155                 160 


Gly His Ile Phe Thr Asp Asn Met His Ile Gln Ala Ile Tyr Asn Ile 
                165                 170                 175     


Phe Asp Ile Glu Lys Ile Leu Ala Lys His Ile Thr Asn Ile Ile Tyr 
            180                 185                 190         


Thr Val Asn Ser Phe Asp Arg Asn Tyr Asn Gln Ser Gly Asn Asp Thr 
        195                 200                 205             


Ile Gly Phe Asp Ile Asn Tyr Arg Val Pro Tyr Ser Glu Tyr Gly Gly 
    210                 215                 220                 


Gly Lys Asp Ser Asn Gly Glu Pro Lys Asn Lys Ser Lys Trp Glu Lys 
225                 230                 235                 240 


Arg Lys Asn Phe Ile Lys Phe Tyr Asn Lys Ser Lys Pro His Leu Gly 
                245                 250                 255     


Tyr Tyr Glu Asn Ile Phe Tyr Asp His Gly Glu Pro Ile Ser Glu Glu 
            260                 265                 270         


Lys Phe Tyr Asn Tyr Leu Asn Ile Leu Asn Phe Ile Arg Asn Asn Thr 
        275                 280                 285             


Phe His Tyr Lys Asn Asp Asp Ile Glu Leu Tyr Ser Glu Asn Tyr Ser 
    290                 295                 300                 


Glu Glu Phe Val Phe Ile Asn Cys Leu Asn Lys Phe Val Lys Asn Lys 
305                 310                 315                 320 


Phe Lys Asn Val Asn Lys Asn Phe Ile Ser Asn Glu Lys Asn Asn Leu 
                325                 330                 335     


Tyr Ile Ile Leu Asn Ala Tyr Gly Lys Asp Thr Glu Asn Val Glu Val 
            340                 345                 350         


Val Lys Lys Tyr Ser Lys Glu Leu Tyr Lys Leu Ser Val Leu Lys Thr 
        355                 360                 365             


Asn Lys Asn Leu Gly Val Asn Val Lys Lys Leu Arg Glu Ser Ala Ile 
    370                 375                 380                 


Glu Tyr Gly Tyr Cys Pro Leu Pro Tyr Asp Lys Glu Lys Glu Val Ala 
385                 390                 395                 400 


Lys Leu Ser Ser Ile Lys His Lys Leu Tyr Lys Thr Tyr Asp Phe Val 
                405                 410                 415     


Ile Thr His Tyr Leu Asn Ser Asn Asp Lys Leu Leu Leu Glu Ile Val 
            420                 425                 430         


Glu Ala Leu Arg Leu Ser Lys Asn Asp Asp Glu Lys Glu Asn Val Tyr 
        435                 440                 445             


Lys Lys Tyr Ala Glu Lys Leu Phe Lys Ala Asp Asp Val Ile Asn Pro 
    450                 455                 460                 


Ile Lys Ala Ile Ser Lys Leu Phe Ala Glu Lys Gly Asn Lys Leu Phe 
465                 470                 475                 480 


Lys Glu Met Val Ile Ile Lys Lys Glu Tyr Val Glu Asp Ile Ser Ile 
                485                 490                 495     


Asp Lys Asn Ile Tyr Asp Phe Thr Lys Val Ile Phe Phe Met Thr Cys 
            500                 505                 510         


Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Asn Ile Ile Ser 
        515                 520                 525             


Lys Leu Gln Val Ile Glu Asp His Asn Asn Val Ile Lys Phe Ile Ser 
    530                 535                 540                 


Asn Asn Lys Asp Ala Val Tyr Lys Asp Tyr Ser Asp Lys Tyr Ala Ile 
545                 550                 555                 560 


Phe Arg Asn Ala Gly Lys Ile Ala Thr Glu Leu Glu Ala Ile Lys Ser 
                565                 570                 575     


Ile Val Arg Met Glu Asn Lys Ile Glu Asn Ala Pro Gln Glu Pro Leu 
            580                 585                 590         


Leu Lys Asp Ala Leu Leu Ser Leu Gly Val Ser Asp Asp Thr Lys Val 
        595                 600                 605             


Leu Glu Asn Thr Tyr Lys Lys Tyr Phe Asp Ser Lys Glu Lys Ala Asp 
    610                 615                 620                 


Lys Gln Ser Gln Lys Val Ser Thr Phe Leu Met Asn Asn Val Ile Asn 
625                 630                 635                 640 


Asn Asn Arg Phe Lys Tyr Val Ile Lys Tyr Ile Asn Pro Ala Asp Ile 
                645                 650                 655     


Asn Gly Leu Ala Lys Asn Arg Tyr Leu Val Lys Phe Val Leu Ser Asn 
            660                 665                 670         


Ile Pro Glu Glu Gln Ile Asp Ser Tyr Tyr Lys Leu Phe Ser Asn Glu 
        675                 680                 685             


Glu Glu Pro Ser Cys Glu Glu Lys Ile Lys Leu Leu Thr Lys Lys Ile 
    690                 695                 700                 


Ser Lys Leu Asn Phe Gln Thr Leu Phe Glu Asn Asn Lys Ile Pro Asn 
705                 710                 715                 720 


Val Glu Lys Glu Arg Lys Lys Ala Ile Ile Thr Leu Tyr Phe Thr Ile 
                725                 730                 735     


Val Tyr Ile Leu Val Lys Asn Leu Val Asn Ile Asn Gly Leu Tyr Thr 
            740                 745                 750         


Leu Ala Leu Tyr Phe Val Glu Arg Asp Gly Tyr Phe Tyr Lys Asp Ile 
        755                 760                 765             


Cys Gly Lys Lys Asp Lys Lys Lys Ser Tyr Asn Gly Val Asp Tyr Leu 
    770                 775                 780                 


Leu Leu Pro Glu Ile Phe Ser Gly Ser Lys Tyr Arg Glu Gln Thr Lys 
785                 790                 795                 800 


Asn Leu Lys Leu Pro Lys Glu Lys Asp Arg Asp Ile Met Lys Lys Tyr 
                805                 810                 815     


Leu Pro Asn Asp Lys Asp Arg Glu Gly Tyr Asn Lys Phe Phe Arg Ala 
            820                 825                 830         


Tyr Arg Asn Asn Ile Val His Leu Asn Ile Ile Ala Lys Leu Ser Glu 
        835                 840                 845             


Leu Thr Ser Asn Ile Asp Lys Asp Ile Asn Ser Tyr Phe Asp Ile Tyr 
    850                 855                 860                 


His Tyr Cys Thr Gln Arg Val Met Phe Asn Tyr Cys Lys Glu Asn Asn 
865                 870                 875                 880 


Asn Ile Val Leu Ala Lys Met Lys Asp Leu Ala His Ile Lys Ser Asp 
                885                 890                 895     


Cys Asp Glu Phe Ser Ser Lys His Thr Tyr Pro Phe Ser Ser Ala Val 
            900                 905                 910         


Leu Arg Phe Met Asn Leu Pro Phe Ala Tyr Asn Val Pro Arg Phe Lys 
        915                 920                 925             


Asn Leu Ser Tyr Lys Lys Phe Phe Asp Lys Gln 
    930                 935                 


<210>  3172
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3172

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Met Lys 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Ile Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Asn Arg Val Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3173
<211>  921
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3173

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Gly Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Asn Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp 
    370                 375                 380                 


Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Leu Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn Lys 
785                 790                 795                 800 


Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser 
                805                 810                 815     


Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg 
            820                 825                 830         


Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe 
        835                 840                 845             


Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp 
    850                 855                 860                 


Asp Lys Lys Gln Glu Glu Lys Ile Lys Phe Glu Asp Asp Leu Leu Lys 
865                 870                 875                 880 


Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe 
                885                 890                 895     


Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe 
            900                 905                 910         


Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920     


<210>  3174
<211>  932
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3174

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ile 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Lys Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asp Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asp Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Asn Lys Val Lys Cys Asn Ile Lys Lys Ser Phe Ser Thr Phe Asn 
                245                 250                 255     


Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe Gly Leu Glu Glu Pro 
            260                 265                 270         


Lys Thr Lys Asp Thr Arg Val Ser Gln Ala Tyr Lys Lys Arg Val Tyr 
        275                 280                 285             


His Met Leu Ala Ile Val Gly Gln Ile Arg Gln Cys Val Phe His Asp 
    290                 295                 300                 


Lys Ser Ser Lys Leu Asp Glu Asp Leu Tyr Ser Phe Ile Asp Ile Ile 
305                 310                 315                 320 


Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr Leu Val Asp Glu Arg Phe 
                325                 330                 335     


Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn Lys Val Asn Ile Ser 
            340                 345                 350         


Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala Asp Asp Ile Ile Arg 
        355                 360                 365             


Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln Lys Asn Leu Gly Phe 
    370                 375                 380                 


Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp Glu Tyr Gly Phe Arg 
385                 390                 395                 400 


Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser Lys Met Tyr Lys Leu 
                405                 410                 415     


Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg Asn Asp Val Val Ala 
            420                 425                 430         


Gly Glu Ala Leu Val Arg Lys Leu Arg Phe Ser Met Thr Asp Asp Glu 
        435                 440                 445             


Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala Lys Leu Trp Gly Lys Phe 
    450                 455                 460                 


Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met Asn Gly Asp Val Ile 
465                 470                 475                 480 


Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp Glu Lys Ile Leu Asp 
                485                 490                 495     


Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr Phe Ser Lys Met Ile 
            500                 505                 510         


Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu 
        515                 520                 525             


Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys Glu Phe Leu Lys Ile 
    530                 535                 540                 


Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu Leu Thr Ala Gly Tyr 
545                 550                 555                 560 


Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn Glu Leu Phe Ile Val 
                565                 570                 575     


Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala Ser Ala Lys Leu Thr 
            580                 585                 590         


Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile Asp Asp Asn Ile Thr 
        595                 600                 605             


Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys Glu Lys Gly Lys Gly 
    610                 615                 620                 


Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn Val Ile Glu Ser Ser 
625                 630                 635                 640 


Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala Gln Lys Ile Arg Glu 
                645                 650                 655     


Val Ala Lys Asn Glu Lys Val Val Met Phe Val Leu Gly Gly Ile Pro 
            660                 665                 670         


Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys Val Glu Phe Pro Asp 
        675                 680                 685             


Met Asn Ser Ser Leu Glu Ala Lys Arg Ser Glu Leu Ala Arg Met Ile 
    690                 695                 700                 


Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val Lys Gln Gln Ala Lys 
705                 710                 715                 720 


Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys Ala Val Ile Gly Leu 
                725                 730                 735     


Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn Leu Val Asn Val Asn 
            740                 745                 750         


Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu Arg Asp Phe Gly Leu 
        755                 760                 765             


Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys Asn Leu Lys Asn Asp 
    770                 775                 780                 


Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu Cys Asp Asp Arg Asp 
785                 790                 795                 800 


Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn Lys Arg Leu Arg Lys Cys 
                805                 810                 815     


Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr Arg Lys Tyr 
            820                 825                 830         


Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu Lys Glu Tyr 
        835                 840                 845             


Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile Tyr His Tyr 
    850                 855                 860                 


Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr Lys Gln Glu 
865                 870                 875                 880 


Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His Gly Tyr Thr 
                885                 890                 895     


Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr Asn Ile Pro 
            900                 905                 910         


Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg Asn Glu Tyr 
        915                 920                 925             


Leu Thr Glu Lys 
    930         


<210>  3175
<211>  921
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3175

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Gly Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Asn Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp 
    370                 375                 380                 


Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Leu Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn Lys 
785                 790                 795                 800 


Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser 
                805                 810                 815     


Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg 
            820                 825                 830         


Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe 
        835                 840                 845             


Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp 
    850                 855                 860                 


Asp Lys Lys Gln Glu Glu Lys Ile Lys Phe Glu Asp Asp Leu Leu Lys 
865                 870                 875                 880 


Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe 
                885                 890                 895     


Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe 
            900                 905                 910         


Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920     


<210>  3176
<211>  921
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3176

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Gly Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Asn Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp 
    370                 375                 380                 


Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Leu Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn Lys 
785                 790                 795                 800 


Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser 
                805                 810                 815     


Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg 
            820                 825                 830         


Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe 
        835                 840                 845             


Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp 
    850                 855                 860                 


Asp Lys Lys Gln Glu Glu Lys Ile Lys Phe Glu Asp Asp Leu Leu Lys 
865                 870                 875                 880 


Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe 
                885                 890                 895     


Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe 
            900                 905                 910         


Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920     


<210>  3177
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3177

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Gln Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asn Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Glu Gly Ser Ser Asn Ile Glu Leu Arg Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Asp Glu Ser His Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe Thr Asp 
    210                 215                 220                 


Pro Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Asn Arg Val Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asn Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3178
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3178

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Lys Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asp Asn Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asp Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Phe Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Glu 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Gln Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr 
    850                 855                 860                 


Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  3179
<211>  927
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3179

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Thr Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asp Tyr Asn 
                85                  90                  95      


Gln Thr Gln Leu Ser Ser Lys Asp Ser Ser Asn Ile Glu Leu His Gly 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Leu Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Ser Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Asp Ser Asn 
        195                 200                 205             


Tyr Asp Phe Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe 
    210                 215                 220                 


Thr Asn Pro Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Lys Asn Ile 
225                 230                 235                 240 


Arg Lys Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu 
                245                 250                 255     


Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Asn Ala Leu 
            260                 265                 270         


Glu Ala Tyr Lys Lys Arg Val Tyr Tyr Met Leu Ala Ile Val Gly Gln 
        275                 280                 285             


Ile Arg Gln Cys Val Phe His Asp Leu Thr Asp His Ser Glu Tyr Asp 
    290                 295                 300                 


Leu Tyr Ser Phe Ile Tyr Asn Ser Lys Lys Val Tyr Lys Glu Cys Arg 
305                 310                 315                 320 


Glu Thr Leu Asp Tyr Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys 
                325                 330                 335     


Gly Phe Ile Glu Gly Asn Lys Ile Asn Ile Ser Leu Leu Ile Asp Met 
            340                 345                 350         


Met Lys Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe 
        355                 360                 365             


Ile Val Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu 
    370                 375                 380                 


Arg Glu Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln 
385                 390                 395                 400 


Tyr Asp Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu 
                405                 410                 415     


Phe Cys Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val 
            420                 425                 430         


Arg Lys Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr 
        435                 440                 445             


Ala Asp Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu 
    450                 455                 460                 


Asn Ile Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys 
465                 470                 475                 480 


Ala Asp Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn 
                485                 490                 495     


Ala Ser Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr 
            500                 505                 510         


Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser 
        515                 520                 525             


Lys Phe Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala 
    530                 535                 540                 


Val Asp Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp 
545                 550                 555                 560 


Ser Gln Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser 
                565                 570                 575     


Met Arg Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala 
            580                 585                 590         


Leu Thr Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser 
        595                 600                 605             


Glu Ile Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg 
    610                 615                 620                 


Asn Phe Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu 
625                 630                 635                 640 


Ile Lys Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu 
                645                 650                 655     


Lys Val Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu 
            660                 665                 670         


Arg Tyr Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu 
        675                 680                 685             


Glu Ala Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe 
    690                 695                 700                 


Asp Asp Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val 
705                 710                 715                 720 


Ala Lys Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met 
                725                 730                 735     


Tyr Leu Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile 
            740                 745                 750         


Ala Ile His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile 
        755                 760                 765             


Pro Glu Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser 
    770                 775                 780                 


Gln Thr Leu Cys Glu Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu 
785                 790                 795                 800 


Phe Leu Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile 
                805                 810                 815     


Asn Asn Ala Asp Ser Ile Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala 
            820                 825                 830         


His Leu Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg 
        835                 840                 845             


Thr Val Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys 
    850                 855                 860                 


Ile Thr Lys Arg Glu Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr 
865                 870                 875                 880 


Glu Asp Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys 
                885                 890                 895     


Ala Leu Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu 
            900                 905                 910         


Ser Ile Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925         


<210>  3180
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3180

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Lys Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asp Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Glu Asp Ser Ser Asn Ile Glu Leu Cys Gly 
            100                 105                 110         


Val Thr Lys Val Asn Ile Thr Phe Ser Ser Lys His Gly Leu Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Gln Asn Thr Tyr Tyr Ile 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Val Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Leu Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Asn Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  3181
<211>  921
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3181

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Gly Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Asn Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp 
    370                 375                 380                 


Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn Lys 
785                 790                 795                 800 


Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser 
                805                 810                 815     


Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg 
            820                 825                 830         


Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe 
        835                 840                 845             


Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp 
    850                 855                 860                 


Asp Lys Lys Gln Glu Glu Lys Ile Lys Phe Glu Asp Asp Leu Leu Lys 
865                 870                 875                 880 


Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe 
                885                 890                 895     


Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe 
            900                 905                 910         


Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920     


<210>  3182
<211>  937
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3182

Met Ala Lys Lys Lys Arg Ile Thr Ala Lys Glu Arg Lys Gln Asn His 
1               5                   10                  15      


Arg Glu Ser Leu Met Lys Lys Ala Asp Ser Asn Ala Glu Lys Glu Lys 
            20                  25                  30          


Ala Lys Lys Pro Val Val Glu Asn Lys Pro Asp Thr Ala Ile Pro Lys 
        35                  40                  45              


Asp Asn Thr Pro Lys Pro Asn Lys Glu Ile Lys Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Ala Gly Val Lys Trp Val Ile Lys Ala Asn Asp Asp Val Ala Tyr 
65                  70                  75                  80  


Ile Ser Ser Phe Gly Lys Gly Asn Asn Ser Val Leu Glu Lys Arg Ile 
                85                  90                  95      


Met Gly Asp Val Ser Ser Asn Val Asn Lys Asp Ser His Met Tyr Val 
            100                 105                 110         


Asn Pro Lys Tyr Thr Lys Lys Asn Tyr Glu Ile Lys Asn Gly Phe Ser 
        115                 120                 125             


Ser Gly Ser Ser Leu Val Thr Tyr Pro Asn Lys Pro Asp Lys Asn Ser 
    130                 135                 140                 


Gly Met Asp Ala Leu Cys Leu Lys Pro Tyr Phe Glu Lys Asp Phe Phe 
145                 150                 155                 160 


Gly His Ile Phe Thr Asp Asn Met His Ile Gln Ala Ile Tyr Asn Ile 
                165                 170                 175     


Phe Asp Ile Glu Lys Ile Leu Ala Lys His Ile Thr Asn Ile Ile Tyr 
            180                 185                 190         


Thr Val Asn Ser Phe Asp Arg Asn Tyr Asn Gln Ser Gly Asn Asp Thr 
        195                 200                 205             


Ile Gly Phe Asp Ile Asn Tyr Arg Val Pro Tyr Ser Glu Tyr Gly Gly 
    210                 215                 220                 


Gly Lys Asp Ser Lys Gly Asn Pro Lys Asn Lys Ser Gln Trp Lys Lys 
225                 230                 235                 240 


Arg Asp Asn Phe Ile Lys Phe Tyr Asn Glu Ser Lys Pro His Leu Gly 
                245                 250                 255     


Tyr Tyr Glu Asn Ile Phe Tyr Asp His Gly Glu Pro Ile Ser Glu Glu 
            260                 265                 270         


Lys Phe Tyr Asn Tyr Leu Asn Ile Leu Asn Phe Ile Arg Asn Asn Thr 
        275                 280                 285             


Phe His Tyr Lys Asp Asp Asp Ile Glu Leu Tyr Ser Glu Asn Tyr Ser 
    290                 295                 300                 


Glu Glu Tyr Val Phe Ile Asn Cys Leu Asn Lys Phe Val Lys Asn Lys 
305                 310                 315                 320 


Phe Lys Asn Val Asn Lys Asn Phe Ile Ser Asn Glu Lys Asn Asn Leu 
                325                 330                 335     


Tyr Ile Ile Leu Asn Ala Tyr Gly Lys Asp Thr Glu Asn Val Glu Val 
            340                 345                 350         


Val Lys Lys Tyr Ser Lys Glu Leu Tyr Lys Leu Ser Val Leu Lys Thr 
        355                 360                 365             


Asn Lys Asn Leu Gly Val Asn Val Lys Lys Leu Arg Glu Ser Ala Ile 
    370                 375                 380                 


Glu Tyr Gly Tyr Cys Pro Leu Pro Tyr Asp Lys Glu Lys Glu Val Ala 
385                 390                 395                 400 


Lys Leu Ser Ser Val Lys His Lys Leu Tyr Lys Thr Tyr Asp Phe Val 
                405                 410                 415     


Ile Thr His Tyr Leu Asn Ser Asn Asp Lys Leu Leu Leu Glu Ile Ile 
            420                 425                 430         


Glu Thr Leu Arg Leu Ser Lys Asn Asp Asp Glu Lys Glu Asn Val Tyr 
        435                 440                 445             


Lys Lys Tyr Ala Glu Lys Leu Phe Lys Ala Asp Asp Val Ile Asn Pro 
    450                 455                 460                 


Ile Lys Ala Ile Ser Lys Leu Phe Ala Glu Lys Gly Asn Lys Leu Phe 
465                 470                 475                 480 


Lys Glu Lys Val Ile Ile Lys Lys Glu Tyr Val Glu Asp Ile Ser Ile 
                485                 490                 495     


Asp Lys Asn Ile Tyr Asp Phe Thr Lys Ile Ile Phe Phe Met Thr Cys 
            500                 505                 510         


Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Asn Ile Ile Ser 
        515                 520                 525             


Lys Leu Gln Val Ile Glu Asp His Asn Asn Val Ile Lys Phe Ile Ser 
    530                 535                 540                 


His Asn Lys Asp Ala Val Tyr Lys Asp Tyr Ser Asp Lys Tyr Ala Ile 
545                 550                 555                 560 


Phe Arg Asn Ala Gly Lys Ile Ala Thr Glu Leu Glu Ala Ile Lys Ser 
                565                 570                 575     


Ile Ala Arg Met Lys Asn Lys Ile Glu Asn Ala Pro Gln Glu Pro Leu 
            580                 585                 590         


Leu Asn Asp Ala Leu Leu Ser Leu Gly Val Ser Lys Lys Asp Leu Glu 
        595                 600                 605             


Asn Thr Tyr Lys Lys Tyr Phe Asp Ser Lys Glu Lys Ala Asp Lys Gln 
    610                 615                 620                 


Ser Gln Lys Val Ser Thr Phe Leu Met Asn Asn Val Ile Asn Asn Asn 
625                 630                 635                 640 


Arg Phe Lys Tyr Val Ile Lys Tyr Ile Asn Pro Ala Asp Ile Asn Gly 
                645                 650                 655     


Leu Ala Lys Asn Arg Tyr Leu Val Lys Phe Val Leu Ser Lys Ile Pro 
            660                 665                 670         


Glu Glu Gln Ile Asp Ser Tyr Tyr Lys Leu Phe Ser Asn Glu Glu Glu 
        675                 680                 685             


Pro Ser Cys Glu Glu Lys Ile Lys Leu Leu Thr Lys Lys Ile Ser Lys 
    690                 695                 700                 


Phe Asn Phe Gln Thr Leu Phe Glu Asn Asn Lys Ile Pro Asn Val Glu 
705                 710                 715                 720 


Lys Glu Arg Lys Lys Ala Ile Ile Thr Leu Tyr Phe Thr Ile Ile Tyr 
                725                 730                 735     


Ile Leu Val Lys Asn Leu Val Asn Ile Asn Gly Leu Tyr Thr Leu Ala 
            740                 745                 750         


Leu Tyr Phe Val Glu Arg Asp Gly Tyr Phe Tyr Lys Lys Ile Cys Gly 
        755                 760                 765             


Lys Lys Asp Lys Lys Lys Ser Tyr Glu Asp Val Asp Tyr Leu Leu Leu 
    770                 775                 780                 


Pro Glu Ile Phe Ser Gly Ser Lys Tyr Arg Glu Glu Thr Lys Asn Leu 
785                 790                 795                 800 


Lys Leu Pro Lys Glu Lys Asp Arg Asp Ile Met Lys Lys Tyr Leu Pro 
                805                 810                 815     


Asn Glu Lys Asp Arg Glu Lys Tyr Asn Lys Phe Phe Thr Ala Tyr Arg 
            820                 825                 830         


Asn Asn Ile Val His Leu Asn Ile Ile Ala Lys Leu Ser Lys Leu Thr 
        835                 840                 845             


Lys Asn Ile Asp Lys Asp Ile Asn Ser Tyr Phe Asp Ile Tyr His Tyr 
    850                 855                 860                 


Cys Thr Gln Arg Val Met Phe Asn Tyr Cys Lys Glu Lys Asn Asp Val 
865                 870                 875                 880 


Val Leu Ala Lys Met Lys Asp Leu Ala His Ile Lys Ser Asp Cys Asp 
                885                 890                 895     


Glu Phe Ser Ser Lys His Thr Tyr Pro Phe Ser Ser Ala Val Leu Arg 
            900                 905                 910         


Phe Met Asn Leu Pro Phe Ala Tyr Asn Val Pro Arg Phe Lys Asn Leu 
        915                 920                 925             


Ser Tyr Lys Lys Phe Phe Asp Lys Gln 
    930                 935         


<210>  3183
<211>  920
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3183

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Val Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Val Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asn Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Gly Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr Asn 
    210                 215                 220                 


Pro Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Val Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Asp Asp Tyr 
            340                 345                 350         


Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys 
        355                 360                 365             


Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met 
    370                 375                 380                 


Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val 
385                 390                 395                 400 


Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr 
                405                 410                 415     


Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg 
            420                 425                 430         


Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala 
        435                 440                 445             


Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp 
    450                 455                 460                 


His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp 
465                 470                 475                 480 


Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu 
                485                 490                 495     


Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly 
            500                 505                 510         


Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn 
        515                 520                 525             


Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu 
    530                 535                 540                 


Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile 
545                 550                 555                 560 


Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro 
                565                 570                 575     


Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu 
            580                 585                 590         


Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys 
        595                 600                 605             


Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr 
    610                 615                 620                 


Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala 
625                 630                 635                 640 


Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met 
                645                 650                 655     


Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys 
            660                 665                 670         


Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg 
        675                 680                 685             


Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Cys Phe Asp Asp Phe Lys 
    690                 695                 700                 


Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg 
705                 710                 715                 720 


Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val 
                725                 730                 735     


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys 
            740                 745                 750         


Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Val Ser Glu Leu Ala 
        755                 760                 765             


Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys 
    770                 775                 780                 


Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg 
785                 790                 795                 800 


Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met 
                805                 810                 815     


Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu 
            820                 825                 830         


Leu Lys Glu Tyr Ile Gly Asp Ile Arg Ala Val Asp Ser Tyr Phe Ser 
        835                 840                 845             


Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Gly Asn Asp 
    850                 855                 860                 


Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn 
865                 870                 875                 880 


His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly 
                885                 890                 895     


Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp 
            900                 905                 910         


Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920 


<210>  3184
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3184

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Cys Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Ile Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Ile Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Glu 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Tyr Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Val Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


His Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Lys Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3185
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3185

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Ile Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Pro Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn His Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3186
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3186

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Gly 
    850                 855                 860                 


Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3187
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3187

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Ile Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Pro Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn His Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3188
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3188

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Lys Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asn Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Asp Glu Ser His Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe Thr Asp 
    210                 215                 220                 


Pro Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Asn Ala Leu Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Pro Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp Asp Ile 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  3189
<211>  923
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3189

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Val Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Glu Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asn Ser Ser Asn Ile Glu Leu Arg Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Gly Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu His Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Asp Asp Tyr 
            340                 345                 350         


Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys 
        355                 360                 365             


Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met 
    370                 375                 380                 


Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val 
385                 390                 395                 400 


Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr 
                405                 410                 415     


Tyr Arg Asn Asp Val Ile Ala Gly Glu Ala Leu Val Arg Lys Leu Arg 
            420                 425                 430         


Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala 
        435                 440                 445             


Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp 
    450                 455                 460                 


His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp 
465                 470                 475                 480 


Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu 
                485                 490                 495     


Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly 
            500                 505                 510         


Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn 
        515                 520                 525             


Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu 
    530                 535                 540                 


Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile 
545                 550                 555                 560 


Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro 
                565                 570                 575     


Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu 
            580                 585                 590         


Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys 
        595                 600                 605             


Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr 
    610                 615                 620                 


Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala 
625                 630                 635                 640 


Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met 
                645                 650                 655     


Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys 
            660                 665                 670         


Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg 
        675                 680                 685             


Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys 
    690                 695                 700                 


Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg 
705                 710                 715                 720 


Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val 
                725                 730                 735     


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys 
            740                 745                 750         


Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala 
        755                 760                 765             


Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys 
    770                 775                 780                 


Glu Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys 
785                 790                 795                 800 


Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp 
                805                 810                 815     


Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val 
            820                 825                 830         


Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser 
        835                 840                 845             


Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg 
    850                 855                 860                 


Glu Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu 
865                 870                 875                 880 


Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser 
                885                 890                 895     


Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln 
            900                 905                 910         


Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920             


<210>  3190
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3190

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Ile Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Pro Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn His Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3191
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3191

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Gly 
    850                 855                 860                 


Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3192
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3192

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys Arg Gly Asn Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Lys Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Ala Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Thr Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Thr Tyr Ala Asp 
        435                 440                 445             


Glu Ala Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Ala Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3193
<211>  946
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3193

Met Lys Lys Phe Ser Asn Ile Lys Arg Leu Gly Val Lys Ser Val His 
1               5                   10                  15      


Tyr Ala Asn Asn Thr Val Ile Val Glu Asp His Phe Ser Lys Asn Thr 
            20                  25                  30          


Asn Ile Leu Phe Thr Ala Glu Tyr Glu Asn Ile Asp Asp Leu Lys Ser 
        35                  40                  45              


Cys Thr Asn Ile Asp Lys Thr Ala Glu Asn Lys Gly Val Arg Phe Thr 
    50                  55                  60                  


Asp Leu Lys Asn Lys Asn Gly Phe Glu Leu Ser Ala Met Ala Gln Lys 
65                  70                  75                  80  


Gln Ile Leu Lys Ser Arg Val Asn Arg Val Lys Lys Val Ser Tyr Thr 
                85                  90                  95      


Gln Glu Leu Phe Asp Ile Thr Thr Asp Asn Asn Ile Glu Val Gln Ile 
            100                 105                 110         


Phe Ser Asn Leu Glu Asp Val Lys Lys Val Ile Ala Pro Tyr Tyr Asn 
        115                 120                 125             


Asn Val Ala Tyr Ala Ile Asn Ser Leu Tyr Arg Asp Ile Ser Asn Asp 
    130                 135                 140                 


Asp Ser Tyr Gly Phe Asp Lys Ile Gly Ser Ile Pro Val Asp Ala Asp 
145                 150                 155                 160 


Trp Tyr Asn Phe Leu Lys Asp Ala Pro Asp Lys Lys Glu Lys Trp Thr 
                165                 170                 175     


Thr Tyr Ile Ile Pro Ser Tyr Lys Lys Val Ile Ala Arg Phe Gly Ile 
            180                 185                 190         


Gln Met Glu Lys Asn Gln Gln Val Asn Phe Cys Lys Cys Leu Glu Tyr 
        195                 200                 205             


Val Ala Ile Arg Asn Gly Leu Phe Val Lys Phe Lys Asp Glu Lys Val 
    210                 215                 220                 


Asp Pro Asp Lys Leu Leu Asn Lys Lys Ile Gln Glu Lys Leu Asp Lys 
225                 230                 235                 240 


Leu Ile Ser Asp Lys Glu Val Asn Asp Lys Leu Phe Glu Leu Ala Lys 
                245                 250                 255     


Thr Pro Val Ser Glu Phe Cys Ala Glu Ala Asn Ala Ile Pro Leu Tyr 
            260                 265                 270         


Arg Tyr Ala Phe Ile Gly Gln Lys Gly Lys Arg Ile Glu Lys Ile Val 
        275                 280                 285             


Leu Asp Lys Leu Glu Glu Asn Glu Ile Leu Ser Ser Leu Val Arg Lys 
    290                 295                 300                 


Ile Asp Glu Asn Glu Thr Thr Tyr Asn Tyr Leu Arg Leu Leu Ser Ala 
305                 310                 315                 320 


Ile Arg Gln Tyr Val Val His Asn Ser Arg Lys Val Arg Ile Asp Lys 
                325                 330                 335     


Asn Val Phe Ile Asn Asp Thr Ala Lys Arg Asp Val Glu Glu Phe Ala 
            340                 345                 350         


Lys Gln Phe Gln Lys Asn Asn Tyr Lys Tyr Phe Cys Ile Leu Lys Glu 
        355                 360                 365             


Leu Tyr Ser Asp Ser Asp Ile Leu Glu Gln Phe Phe Asp Tyr Thr Val 
    370                 375                 380                 


Phe Asp Glu Ala Arg Asn Leu Lys Ile Ser Ile Asp Lys Ile Lys Lys 
385                 390                 395                 400 


Gly Ile Thr Ala Asn Ile Asp Ile Ser Ala Asp Val Glu Pro Asp Lys 
                405                 410                 415     


Leu Ser Glu Tyr Ala Asn Lys Phe Arg Thr Val Thr Met Phe Ala Leu 
            420                 425                 430         


Thr Lys Tyr Leu Lys Glu Asn Val Gly Glu Ile Glu Asp Phe Leu Ala 
        435                 440                 445             


Asn Ile Lys Val Cys Ser Ser Asp Glu Glu Lys Ala Gly Val Tyr Glu 
    450                 455                 460                 


Gln Lys Ala Lys Glu Phe Ile Thr Lys Phe Asp Ser Phe Lys Asp Ile 
465                 470                 475                 480 


Arg Ser Val Val Lys Lys His Leu Gly Thr Gln Lys Val Asn Glu Lys 
                485                 490                 495     


Phe Asp Phe Tyr Pro Ser Asp Ile Asn Phe Gly Arg Asp Ser Asn Val 
            500                 505                 510         


Phe Phe Asn Met Leu Tyr Val Met Ser Lys Phe Leu Thr Val Asn Glu 
        515                 520                 525             


Ala Arg Ile Met Phe Gln Lys Ile Lys Ser Lys Tyr Asp Ser Val Lys 
    530                 535                 540                 


Ser Leu Leu Lys Ile Ala Glu Leu Thr Gly Val Thr Leu Ser Asp Asn 
545                 550                 555                 560 


Leu Phe Asp Arg Phe Arg Met Ile Phe Asp Lys Glu Arg Val Asp Glu 
                565                 570                 575     


Tyr Gln Lys Gln Leu Ile Val Leu Gln Ser Ile Arg Thr Arg Asn Gly 
            580                 585                 590         


Val Ser Gln Glu Gly Phe Ala Lys Glu Leu Lys Arg Ile Phe Asp Met 
        595                 600                 605             


Phe Lys Lys Asp Asp Ile Ser Tyr Glu Glu Phe Glu Lys Glu Leu Ser 
    610                 615                 620                 


Leu Asp Glu Asn Gln Asn Glu Ile Lys Asn Lys Ser Phe Lys Leu Lys 
625                 630                 635                 640 


Pro Leu Lys Ser Tyr Leu Arg Asn Asp Val Tyr Lys Ser Lys Gln Tyr 
                645                 650                 655     


Gln Tyr Ile Ser Ser Phe Ala Ser Ala Gly Ile Cys Gln Lys Ile Met 
            660                 665                 670         


Glu Asn Lys Asp Ile Val Ala Phe Val Leu Asn Gly Met Leu Tyr Gln 
        675                 680                 685             


Glu Gly Lys Leu Ser Met Pro Met His Lys Tyr Val Ala Lys Val Tyr 
    690                 695                 700                 


His Asp Phe Arg Arg Glu Lys Ile Asp Glu Asn Ser Ala Asn Tyr Leu 
705                 710                 715                 720 


Leu Asp Gln Asn Gln Ile Ser Ser Leu Val Asn Ser Leu Cys Asp Leu 
                725                 730                 735     


Lys Leu Glu Asn Ile Ile Glu Ala Ile Phe Lys Glu Ser Arg Val Asn 
            740                 745                 750         


Tyr Lys Ala Leu Val Arg Leu Tyr Leu Asn Ile Cys Tyr Leu Phe Val 
        755                 760                 765             


Lys Asn Ile Ile Ser Leu Asn Ser Thr Tyr Leu Ile Gln Phe Gln Asp 
    770                 775                 780                 


Tyr Glu Asn Ile Tyr Lys Gln Leu His Leu Glu Asp Leu Met Asp Ile 
785                 790                 795                 800 


Thr Tyr Asp Phe Gly Val Leu Asn Asn Phe Val Glu Asn Ala Pro Asn 
                805                 810                 815     


Lys Lys Cys Arg Ser Tyr Met Gln Leu Gln Thr Leu Leu Glu Lys Asp 
            820                 825                 830         


Tyr Ile Lys Asp Tyr Ile Tyr Thr Pro Glu Tyr Gln Val Leu Gln Asp 
        835                 840                 845             


Arg Tyr Arg Asn Leu Val Val His Ser Ser Leu Leu Phe Gly Leu Asp 
    850                 855                 860                 


Lys Ile Asp Phe Asp Phe Gly Glu Val Gln Asn Ile Ser Ser Tyr Phe 
865                 870                 875                 880 


Ala Ile Tyr Gln Thr Leu Val Gln Arg Leu Val Glu Gln Asp Ala Arg 
                885                 890                 895     


Glu Val Trp Gly Glu Lys Phe Asp Glu Tyr Phe Ala Leu Asn Asn Gly 
            900                 905                 910         


Lys Thr Tyr Ser Thr Lys Leu Cys Ile Ala Leu Asn Met Pro Tyr Ala 
        915                 920                 925             


Tyr Asn Ile Ser Arg Phe Asn Asn Asn Thr Ile Glu Lys Tyr Ser Asn 
    930                 935                 940                 


Lys Arg 
945     


<210>  3194
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3194

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Gln Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ser Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala 
        675                 680                 685             


Lys Cys Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asp Asp Lys Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  3195
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3195

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Ile Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Pro Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn His Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3196
<211>  956
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3196

Met Ala Lys Lys Lys Arg Ile Thr Ala Lys Glu Arg Lys Gln Asn His 
1               5                   10                  15      


Arg Glu Ser Leu Met Lys Lys Ala Asp Ser Asn Ala Glu Lys Glu Lys 
            20                  25                  30          


Ala Lys Lys Pro Val Val Glu Asn Lys Pro Asp Thr Ala Ile Ser Lys 
        35                  40                  45              


Asp Asn Thr Pro Lys Pro Asn Lys Glu Ile Lys Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Ala Gly Val Lys Trp Val Ile Lys Ala Asn Asp Asp Val Ala Tyr 
65                  70                  75                  80  


Ile Ser Ser Phe Gly Lys Gly Asn Asn Ser Val Leu Glu Lys Arg Ile 
                85                  90                  95      


Ile Gly Asp Val Ser Ser Asp Val Asn Lys Asp Ser His Met Tyr Val 
            100                 105                 110         


Asn Pro Lys Tyr Thr Lys Lys Asn Tyr Glu Ile Lys Asn Gly Phe Ser 
        115                 120                 125             


Ser Gly Ser Ser Leu Thr Thr His Pro Asn Lys Pro Asp Lys Asn Ser 
    130                 135                 140                 


Gly Met Asp Ala Leu Cys Leu Lys Ile Tyr Phe Glu Lys Glu Ile Phe 
145                 150                 155                 160 


Lys Asp Lys Phe Asn Asp Asn Met His Ile Gln Thr Ile Tyr Asn Ile 
                165                 170                 175     


Phe Asp Ile Glu Lys Thr Leu Ala Lys His Ile Thr Asn Ile Ile Tyr 
            180                 185                 190         


Ala Val Asn Ser Leu Asp Arg Ser Tyr Ile Gln Ser Gly Asn Asp Thr 
        195                 200                 205             


Ile Gly Phe Gly Leu Asn Tyr Arg Ile Pro Tyr Ala Lys Tyr Gly Arg 
    210                 215                 220                 


Gly Lys Asp Ser Asn Gly Lys Pro Asn Asn Ser Asn Leu Lys Lys Arg 
225                 230                 235                 240 


Glu Ser Phe Ile Lys Phe Tyr Asn Asn Ala Lys Asp Arg Phe Gly Tyr 
                245                 250                 255     


Phe Glu Ser Val Phe Tyr Gln Asn Gly Lys Pro Ile Ser Arg Glu Lys 
            260                 265                 270         


Leu Tyr Ile Tyr Leu Asn Ile Leu Asn Phe Val Arg Asn Ser Thr Phe 
        275                 280                 285             


His Tyr Asn Asn Thr Ser Thr Tyr Leu Tyr Arg Lys Glu Tyr Lys Tyr 
    290                 295                 300                 


Thr Asp Lys Asp Asn Cys Ser Val Lys Glu Phe Glu Phe Val Ser Tyr 
305                 310                 315                 320 


Leu Asn Glu Phe Val Lys Asn Lys Phe Lys Asn Val Asn Lys Asn Phe 
                325                 330                 335     


Ile Ser Asn Glu Lys Asn Asn Leu Tyr Ile Ile Leu Asn Ala Tyr Gly 
            340                 345                 350         


Glu Asp Ile Glu Asp Val Glu Val Val Lys Lys Tyr Ser Lys Glu Leu 
        355                 360                 365             


Tyr Lys Leu Ser Val Leu Lys Thr Asn Lys Asn Leu Gly Val Asn Val 
    370                 375                 380                 


Lys Lys Leu Arg Glu Ser Ala Ile Glu Tyr Gly Tyr Cys Pro Leu Pro 
385                 390                 395                 400 


Tyr Asp Lys Glu Lys Glu Val Ala Lys Leu Ser Ser Ile Lys His Lys 
                405                 410                 415     


Leu Tyr Lys Thr Tyr Asp Phe Val Ile Thr His Tyr Leu Asn Ser Asn 
            420                 425                 430         


Asp Lys Leu Leu Leu Glu Ile Val Glu Ala Leu Arg Leu Ser Lys Asn 
        435                 440                 445             


Asp Asp Glu Lys Glu Asn Val Tyr Lys Ile Tyr Ala Glu Lys Ile Phe 
    450                 455                 460                 


Lys Ala Glu Tyr Val Ile Asn Pro Ile Lys Thr Ile Ser Asn Leu Phe 
465                 470                 475                 480 


Ala Glu Lys Gly Asp Lys Leu Phe Asn Glu Lys Val Ser Ile Ser Glu 
                485                 490                 495     


Glu Tyr Val Glu Asp Ile Arg Ile Asp Lys Asn Ile His Asn Phe Thr 
            500                 505                 510         


Lys Val Ile Phe Phe Leu Thr Cys Phe Leu Asp Gly Lys Glu Ile Asn 
        515                 520                 525             


Asp Leu Leu Thr Asn Ile Ile Ser Lys Leu Gln Val Ile Glu Asp His 
    530                 535                 540                 


Asn Asn Val Ile Lys Ala Ile Ala Asn Asn Asn Asp Ala Val Tyr Lys 
545                 550                 555                 560 


Asp Tyr Ser Asp Lys Tyr Ala Val Phe Lys Asn Ser Gly Lys Ile Ala 
                565                 570                 575     


Thr Lys Leu Glu Ala Ile Lys Ser Ile Ala Arg Met Glu Asn Lys Ile 
            580                 585                 590         


Asn Lys Ala Phe Lys Glu Pro Leu Leu Lys Asp Ala Met Leu Ala Leu 
        595                 600                 605             


Gly Val Ser Pro Asn Asp Leu Asp Glu Lys Tyr Glu Lys Tyr Phe Lys 
    610                 615                 620                 


Thr Asp Val Asp Ala Asp Lys Asp His Gln Lys Val Ser Thr Phe Leu 
625                 630                 635                 640 


Met Asn Asn Val Ile Asn Asn Ser Arg Phe Lys Tyr Val Val Lys Tyr 
                645                 650                 655     


Ile Asn Pro Ala Asp Ile Asn Arg Leu Ala Lys Asn Lys His Leu Val 
            660                 665                 670         


Lys Phe Val Leu Asp Gln Ile Pro His Lys Gln Ile Asp Ser Tyr Tyr 
        675                 680                 685             


Asn Ser Val Cys Thr Val Glu Glu Pro Ser Tyr Lys Gly Lys Ile Gln 
    690                 695                 700                 


Leu Leu Thr Lys Lys Ile Thr Gly Leu Asn Phe Tyr Ser Leu Phe Glu 
705                 710                 715                 720 


Asn Cys Lys Ile Pro Asn Val Glu Lys Glu Lys Lys Lys Ala Val Ile 
                725                 730                 735     


Thr Leu Tyr Phe Thr Ile Ile Tyr Ile Leu Val Lys Asn Leu Val Asn 
            740                 745                 750         


Ile Asn Gly Leu Tyr Thr Leu Ala Leu Tyr Phe Val Glu Arg Asp Gly 
        755                 760                 765             


Phe Phe Tyr Lys Lys Ile Cys Glu Lys Lys Asp Lys Lys Lys Thr Asn 
    770                 775                 780                 


Lys Asp Val Asp Tyr Leu Leu Leu Pro Glu Ile Phe Ser Gly Ser Lys 
785                 790                 795                 800 


Tyr Arg Glu Glu Thr Lys Asn Leu Lys Leu Pro Lys Glu Lys Asp Arg 
                805                 810                 815     


Glu Ile Met Lys Lys Tyr Leu Pro Asn Asp Glu Asp Arg Lys Glu Tyr 
            820                 825                 830         


Asn Lys Phe Phe Lys Gln Tyr Arg Asn Asn Ile Val His Leu Asn Ile 
        835                 840                 845             


Ile Ala Asn Leu Ser Lys Leu Thr Ser Thr Ile Asp Lys Glu Ile Asn 
    850                 855                 860                 


Ser Tyr Phe Glu Ile Phe His Tyr Cys Ala Gln Arg Val Met Phe Asp 
865                 870                 875                 880 


Tyr Cys Lys Asn Asn Asn Lys Val Val Leu Ala Lys Met Lys Asp Leu 
                885                 890                 895     


Ala His Ile Lys Ser Asp Cys Asp Glu Phe Ser Ser Lys Tyr Thr Tyr 
            900                 905                 910         


Pro Tyr Ser Ser Ala Val Leu Arg Phe Met Asn Leu Pro Phe Ala Tyr 
        915                 920                 925             


Asn Val Pro Arg Phe Lys Asn Leu Ser Tyr Gln Lys Phe Phe Asp Lys 
    930                 935                 940                 


Gln Arg Leu Glu Ala Leu Glu Lys Asn Leu Asn Ile 
945                 950                 955     


<210>  3197
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3197

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Ile Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Pro Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn His Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3198
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3198

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Met Lys 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Ile Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Asn Arg Val Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3199
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3199

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Phe 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Ala Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Val Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Lys Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3200
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3200

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Phe 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Ala Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Val Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Lys Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3201
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3201

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Ile Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Pro Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn His Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3202
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3202

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Gly Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asp Tyr Asn 
                85                  90                  95      


Gln Thr Gln Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu Cys Gly 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser 
        195                 200                 205             


His Asp Asp Phe Ile Gly Tyr Leu Ser Thr Asn Asn Ile Tyr Asp Val 
    210                 215                 220                 


Phe Ile Asp Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn 
225                 230                 235                 240 


Val Arg Lys Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asn Asn Ile Asp His Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Glu Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Ile Ala Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3203
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3203

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Ile Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Pro Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn His Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3204
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3204

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asp Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Phe Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Lys Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Ala Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Leu Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr Tyr Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Leu Ser Glu His Ser Glu Tyr Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Asn Ser Lys Lys Val Tyr Arg Glu Cys Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ala Lys Leu Trp Val Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3205
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3205

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asp Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Phe Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Lys Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Ala Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Leu Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr Tyr Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Leu Ser Glu His Ser Glu Tyr Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Asn Ser Lys Lys Val Tyr Arg Glu Cys Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ala Lys Leu Trp Val Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3206
<211>  954
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3206

Met Gly Lys Lys Ile His Ala Arg Asp Leu Arg Glu Gln Arg Lys Thr 
1               5                   10                  15      


Asp Arg Thr Val Lys Phe Ala Asp Gln Asn Lys Lys Arg Glu Ala Glu 
            20                  25                  30          


Arg Ala Val Gln Lys Lys Asp Ala Ala Val Ser Val Lys Ser Val Ser 
        35                  40                  45              


Ser Val Ser Ser Lys Lys Asp Asn Val Thr Lys Ser Met Ala Lys Ala 
    50                  55                  60                  


Ala Gly Val Lys Ser Val Phe Ala Val Gly Asn Thr Val Tyr Met Thr 
65                  70                  75                  80  


Ser Phe Gly Arg Gly Asn Asp Ala Val Leu Glu Gln Lys Ile Val Asp 
                85                  90                  95      


Thr Ser His Glu Pro Leu Asn Ile Asp Asp Pro Ala Tyr Gln Leu Asn 
            100                 105                 110         


Val Val Thr Met Asn Gly Tyr Ser Val Thr Gly His Arg Gly Glu Thr 
        115                 120                 125             


Val Ser Ala Val Thr Asp Asn Pro Leu Arg Arg Phe Asn Gly Gly Lys 
    130                 135                 140                 


Lys Gly Glu Gln Gly Gln Ser Val Pro Thr Asp Met Leu Cys Leu Lys 
145                 150                 155                 160 


Pro Thr Leu Glu Lys Lys Phe Phe Gly Lys Glu Phe Asn Asp Asn Ile 
                165                 170                 175     


His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala 
            180                 185                 190         


Val Tyr Ser Thr Asn Ala Ile Tyr Ala Leu Asn Asn Met Ser Ala Asp 
        195                 200                 205             


Glu Asn Ile Glu Asn Ser Asp Phe Phe Met Lys Arg Thr Thr Asp Glu 
    210                 215                 220                 


Thr Phe Asp Asp Phe Glu Lys Lys Lys Glu Ser Thr Asn Ser Arg Glu 
225                 230                 235                 240 


Lys Ala Asp Phe Asp Ala Phe Glu Lys Phe Ile Gly Asn Tyr Arg Leu 
                245                 250                 255     


Ala Tyr Phe Ala Asp Ala Phe Tyr Val Asn Lys Lys Asn Pro Lys Gly 
            260                 265                 270         


Lys Ala Arg Asn Val Leu Arg Glu Asp Lys Glu Leu Tyr Ser Val Leu 
        275                 280                 285             


Thr Leu Ile Gly Lys Leu Arg His Trp Cys Val His Ser Glu Glu Gly 
    290                 295                 300                 


Arg Ala Glu Phe Trp Leu Tyr Lys Leu Asp Glu Leu Lys Asp Asp Phe 
305                 310                 315                 320 


Lys Asn Val Leu Asp Val Val Tyr Asn Arg Pro Val Glu Glu Ile Asn 
                325                 330                 335     


Asn Arg Phe Ile Glu Asn Asn Lys Val Asn Ile Gln Ile Leu Gly Ser 
            340                 345                 350         


Val Tyr Lys Asn Thr Asp Ile Ala Glu Leu Val Arg Ser Tyr Tyr Glu 
        355                 360                 365             


Phe Leu Ile Thr Lys Lys Tyr Lys Asn Met Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Ser Met Leu Glu Gly Lys Gly Tyr Ala Asp Lys Glu Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Asn Lys Leu Tyr Gln Met Thr Asp Phe Ile Leu Tyr 
                405                 410                 415     


Thr Gly Tyr Ile Asn Glu Asp Ser Asp Arg Ala Asp Asp Leu Val Asn 
            420                 425                 430         


Ala Leu Arg Ser Ser Leu Lys Glu Asp Asp Lys Thr Thr Val Tyr Cys 
        435                 440                 445             


Lys Glu Ala Asp Tyr Leu Trp Lys Lys Tyr Arg Glu Ser Ile Arg Glu 
    450                 455                 460                 


Val Ala Glu Ala Leu Asp Gly Asp Asn Ile Lys Arg Leu Ser Lys Ser 
465                 470                 475                 480 


Asn Ile Glu Ile Gln Glu Asp Lys Leu Arg Lys Cys Phe Ile Ser Tyr 
                485                 490                 495     


Ala Asp Ser Val Ser Glu Phe Thr Lys Leu Ile Tyr Leu Leu Thr Arg 
            500                 505                 510         


Phe Leu Ser Gly Lys Glu Ile Asn Asp Leu Val Thr Thr Leu Ile Asn 
        515                 520                 525             


Lys Phe Asp Asn Ile Arg Ser Phe Leu Glu Ile Met Asp Glu Leu Gly 
    530                 535                 540                 


Leu Asp Arg Thr Phe Thr Ala Glu Tyr Ser Phe Phe Glu Gly Ser Thr 
545                 550                 555                 560 


Lys Tyr Leu Ala Glu Leu Val Glu Leu Asn Ser Phe Val Lys Ser Cys 
                565                 570                 575     


Ser Phe Asp Ile Asn Ala Lys Arg Thr Met Tyr Arg Asp Ala Leu Asp 
            580                 585                 590         


Ile Leu Gly Ile Lys Ser Gly Lys Thr Glu Glu Asp Ile Glu Lys Met 
        595                 600                 605             


Ile Asp Asn Ile Leu Gln Ile Asp Ala Asn Gly Asp Lys Lys Leu Lys 
    610                 615                 620                 


Lys Asn Asn Gly Leu Arg Asn Phe Ile Ala Ser Asn Val Ile Asp Ser 
625                 630                 635                 640 


Asn Arg Phe Lys Tyr Leu Val Arg Tyr Gly Asn Pro Lys Lys Ile Arg 
                645                 650                 655     


Glu Thr Ala Lys Cys Glu Pro Ala Val Arg Phe Val Leu Asn Glu Ile 
            660                 665                 670         


Pro Asp Ala Gln Ile Glu Arg Tyr Tyr Glu Ala Cys Cys Pro Lys Asn 
        675                 680                 685             


Thr Ala Leu Cys Ser Ala Asn Lys Arg Arg Glu Lys Leu Ala Asp Met 
    690                 695                 700                 


Ile Ala Glu Ile Glu Phe Glu Asn Phe Ser Asp Ala Gly Asn Tyr Gln 
705                 710                 715                 720 


Lys Ala Asn Val Thr Ser Lys Thr His Glu Ala Glu Ile Lys Arg Lys 
                725                 730                 735     


Asn Gln Ala Ile Ile Arg Leu Tyr Leu Thr Val Met Tyr Ile Met Leu 
            740                 745                 750         


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Phe His Cys 
        755                 760                 765             


Val Glu Arg Asp Thr Lys Leu Tyr Ala Glu Ser Gly Leu Glu Val Gly 
    770                 775                 780                 


Asn Ile Glu Lys Asn Lys Thr Asn Leu Thr Met Ala Val Met Gly Val 
785                 790                 795                 800 


Lys Leu Glu Asn Gly Ile Ile Lys Thr Glu Phe Asp Lys Ser Leu Ala 
                805                 810                 815     


Glu Asn Ala Ala Asn Arg Tyr Leu Arg Asn Ala Arg Trp Tyr Lys Leu 
            820                 825                 830         


Ile Leu Asp Asn Leu Lys Lys Ser Glu Arg Ala Val Val Asn Glu Phe 
        835                 840                 845             


Arg Asn Thr Val Cys His Leu Asn Ala Ile Arg Asn Ile Asn Ile Asn 
    850                 855                 860                 


Ile Asp Gly Ile Lys Glu Val Glu Asn Tyr Phe Ala Leu Tyr His Tyr 
865                 870                 875                 880 


Leu Ile Gln Lys His Leu Glu Lys Arg Phe Ala Asp Lys Lys Val Glu 
                885                 890                 895     


Arg Asp Thr Gly Asp Phe Ile Ser Lys Leu Glu Glu His Lys Thr Tyr 
            900                 905                 910         


Cys Lys Asp Phe Val Lys Ala Tyr Cys Thr Pro Phe Gly Tyr Asn Leu 
        915                 920                 925             


Val Arg Tyr Lys Asn Leu Thr Ile Asp Gly Leu Phe Asp Lys Asn Tyr 
    930                 935                 940                 


Pro Gly Lys Asp Asp Ser Asp Lys Gln Lys 
945                 950                 


<210>  3207
<211>  918
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3207

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Gly Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Asn Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp 
    370                 375                 380                 


Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Gly Val Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ser Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu Arg 
785                 790                 795                 800 


Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr Arg 
                805                 810                 815     


Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu Lys 
            820                 825                 830         


Glu Tyr Ile Gly Asp Ile Cys Thr Val Asp Ser Tyr Phe Ser Ile Tyr 
        835                 840                 845             


His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr Lys 
    850                 855                 860                 


Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His Gly 
865                 870                 875                 880 


Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr Asn 
                885                 890                 895     


Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg Asn 
            900                 905                 910         


Glu Tyr Leu Thr Glu Lys 
        915             


<210>  3208
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3208

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Val Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Met Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Glu Ser Ser Ser Asn Ile Lys Leu Cys Gly 
            100                 105                 110         


Val Thr Lys Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Gln Asn Thr Tyr Tyr Ile 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe 
    290                 295                 300                 


Asp Ile Tyr Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Tyr Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Val Pro Asp Met Asn Ser Ser Leu Glu Ala 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asp Leu Leu Lys Asn His Gly Tyr Thr Arg Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  3209
<211>  923
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3209

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Val Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Glu Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asn Ser Ser Asn Ile Glu Leu Arg Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Gly Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu His Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Asp Asp Tyr 
            340                 345                 350         


Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys 
        355                 360                 365             


Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met 
    370                 375                 380                 


Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val 
385                 390                 395                 400 


Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr 
                405                 410                 415     


Tyr Arg Asn Asp Val Ile Ala Gly Glu Ala Leu Val Arg Lys Leu Arg 
            420                 425                 430         


Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala 
        435                 440                 445             


Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp 
    450                 455                 460                 


His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp 
465                 470                 475                 480 


Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu 
                485                 490                 495     


Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly 
            500                 505                 510         


Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn 
        515                 520                 525             


Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu 
    530                 535                 540                 


Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile 
545                 550                 555                 560 


Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro 
                565                 570                 575     


Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu 
            580                 585                 590         


Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys 
        595                 600                 605             


Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr 
    610                 615                 620                 


Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala 
625                 630                 635                 640 


Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met 
                645                 650                 655     


Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys 
            660                 665                 670         


Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg 
        675                 680                 685             


Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys 
    690                 695                 700                 


Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg 
705                 710                 715                 720 


Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val 
                725                 730                 735     


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys 
            740                 745                 750         


Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala 
        755                 760                 765             


Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys 
    770                 775                 780                 


Glu Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys 
785                 790                 795                 800 


Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp 
                805                 810                 815     


Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val 
            820                 825                 830         


Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser 
        835                 840                 845             


Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg 
    850                 855                 860                 


Glu Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu 
865                 870                 875                 880 


Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser 
                885                 890                 895     


Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln 
            900                 905                 910         


Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920             


<210>  3210
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3210

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Asp Glu Ser His Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn 
    210                 215                 220                 


Pro Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu His Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Lys Lys Gln Glu Glu Lys Ile Lys Phe Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3211
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3211

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Asp Glu Ser His Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn 
    210                 215                 220                 


Pro Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu His Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Lys Lys Gln Glu Glu Lys Ile Lys Phe Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3212
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3212

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asp Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Phe Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Lys Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Ala Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Leu Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr Tyr Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Leu Ser Glu His Ser Glu Tyr Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Asn Ser Lys Lys Val Tyr Arg Glu Cys Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ala Lys Leu Trp Val Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3213
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3213

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Ile Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Ile Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Asn Arg Val Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu His Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Ile Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Glu 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Lys Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  3214
<211>  923
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3214

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Val Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Glu Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asn Ser Ser Asn Ile Glu Leu Arg Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Lys Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Ser Lys Leu His Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Asp Asp Tyr 
            340                 345                 350         


Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys 
        355                 360                 365             


Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met 
    370                 375                 380                 


Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val 
385                 390                 395                 400 


Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr 
                405                 410                 415     


Tyr Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg 
            420                 425                 430         


Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala 
        435                 440                 445             


Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp 
    450                 455                 460                 


His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp 
465                 470                 475                 480 


Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu 
                485                 490                 495     


Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly 
            500                 505                 510         


Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn 
        515                 520                 525             


Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu 
    530                 535                 540                 


Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile 
545                 550                 555                 560 


Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro 
                565                 570                 575     


Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu 
            580                 585                 590         


Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys 
        595                 600                 605             


Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr 
    610                 615                 620                 


Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala 
625                 630                 635                 640 


Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met 
                645                 650                 655     


Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys 
            660                 665                 670         


Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg 
        675                 680                 685             


Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys 
    690                 695                 700                 


Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg 
705                 710                 715                 720 


Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val 
                725                 730                 735     


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys 
            740                 745                 750         


Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala 
        755                 760                 765             


Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys 
    770                 775                 780                 


Glu Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys 
785                 790                 795                 800 


Asn Arg Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp 
                805                 810                 815     


Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Ile Thr Val 
            820                 825                 830         


Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser 
        835                 840                 845             


Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg 
    850                 855                 860                 


Glu Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu 
865                 870                 875                 880 


Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser 
                885                 890                 895     


Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln 
            900                 905                 910         


Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920             


<210>  3215
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3215

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Ile Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Pro Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn His Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3216
<211>  923
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3216

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Val Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Glu Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asn Ser Ser Asn Ile Glu Leu Arg Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Lys Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Ser Lys Leu His Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Asp Asp Tyr 
            340                 345                 350         


Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys 
        355                 360                 365             


Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met 
    370                 375                 380                 


Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val 
385                 390                 395                 400 


Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr 
                405                 410                 415     


Tyr Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg 
            420                 425                 430         


Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala 
        435                 440                 445             


Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp 
    450                 455                 460                 


His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp 
465                 470                 475                 480 


Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu 
                485                 490                 495     


Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly 
            500                 505                 510         


Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn 
        515                 520                 525             


Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu 
    530                 535                 540                 


Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile 
545                 550                 555                 560 


Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro 
                565                 570                 575     


Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu 
            580                 585                 590         


Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys 
        595                 600                 605             


Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr 
    610                 615                 620                 


Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala 
625                 630                 635                 640 


Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met 
                645                 650                 655     


Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys 
            660                 665                 670         


Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg 
        675                 680                 685             


Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys 
    690                 695                 700                 


Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg 
705                 710                 715                 720 


Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val 
                725                 730                 735     


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys 
            740                 745                 750         


Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala 
        755                 760                 765             


Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys 
    770                 775                 780                 


Glu Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys 
785                 790                 795                 800 


Asn Arg Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp 
                805                 810                 815     


Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Ile Thr Val 
            820                 825                 830         


Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser 
        835                 840                 845             


Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg 
    850                 855                 860                 


Glu Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu 
865                 870                 875                 880 


Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser 
                885                 890                 895     


Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln 
            900                 905                 910         


Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920             


<210>  3217
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3217

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Asp Glu Ser His Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn 
    210                 215                 220                 


Pro Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu Tyr Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Ile Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Glu 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asn Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Lys Lys Gln Glu Glu Lys Ile Lys Phe Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3218
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3218

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Ser Ser Asn Ile Glu Leu Arg Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Lys Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe Thr Asn 
    210                 215                 220                 


Pro Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Lys Asn Ile Arg Lys 
225                 230                 235                 240 


Ser Leu Arg Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu His Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Ile Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Lys Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Arg Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  3219
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3219

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Asp Glu Ser His Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn 
    210                 215                 220                 


Pro Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu Tyr Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Ile Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Glu 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asn Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Lys Lys Gln Glu Glu Lys Ile Lys Phe Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3220
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3220

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asp Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Phe Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Lys Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Ala Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Leu Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr Tyr Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Leu Ser Glu His Ser Glu Tyr Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Asn Ser Lys Lys Val Tyr Arg Glu Cys Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ala Lys Leu Trp Val Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3221
<211>  929
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3221

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Gln Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Cys Val Phe His Asp Leu Ser Glu His Ser Glu Tyr 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Asn Ser Lys Lys Val Tyr Arg Glu Cys 
305                 310                 315                 320 


Arg Glu Thr Leu Asn Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn 
                325                 330                 335     


Lys Gly Phe Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp 
            340                 345                 350         


Met Met Lys Asp Asp Tyr Glu Ala Asp Asp Ile Ile His Leu Tyr Tyr 
        355                 360                 365             


Asp Phe Ile Val Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys 
    370                 375                 380                 


Lys Leu Arg Glu Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp 
385                 390                 395                 400 


Lys Gln Tyr Asp Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe 
                405                 410                 415     


Leu Leu Phe Cys Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala 
            420                 425                 430         


Leu Val Arg Lys Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly 
        435                 440                 445             


Ile Tyr Ala Asp Glu Ala Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp 
    450                 455                 460                 


Phe Glu Asn Ile Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu 
465                 470                 475                 480 


Gly Lys Ala Asp Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys 
                485                 490                 495     


Lys Asn Ala Ser Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu 
            500                 505                 510         


Thr Tyr Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu 
        515                 520                 525             


Ile Ser Lys Phe Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser 
    530                 535                 540                 


Ser Ala Val Asp Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe 
545                 550                 555                 560 


Asn Asp Ser Gln Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile 
                565                 570                 575     


Ala Ser Met Arg Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg 
            580                 585                 590         


Asp Ala Leu Thr Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg 
        595                 600                 605             


Ile Ser Glu Ile Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly 
    610                 615                 620                 


Leu Arg Asn Phe Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val 
625                 630                 635                 640 


Tyr Leu Ile Lys Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys 
                645                 650                 655     


Asn Glu Lys Val Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln 
            660                 665                 670         


Ile Glu Arg Tyr Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser 
        675                 680                 685             


Ser Leu Lys Val Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile 
    690                 695                 700                 


Arg Phe Asp Asp Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu 
705                 710                 715                 720 


Asn Val Ala Lys Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr 
                725                 730                 735     


Val Met Tyr Leu Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr 
            740                 745                 750         


Val Ile Ala Ile His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu 
        755                 760                 765             


Ile Ile Pro Glu Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile 
    770                 775                 780                 


Leu Ser Gln Thr Leu Cys Glu Leu Cys Asp Asp Arg Asp Glu Ser Pro 
785                 790                 795                 800 


Asn Leu Phe Leu Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val 
                805                 810                 815     


Asp Ile Asn Asn Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys 
            820                 825                 830         


Ile Ala His Leu Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp 
        835                 840                 845             


Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln 
    850                 855                 860                 


Arg Cys Ile Thr Lys Arg Glu Asp Asp Lys Lys Gln Glu Glu Lys Ile 
865                 870                 875                 880 


Lys Tyr Glu Asp Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe 
                885                 890                 895     


Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys 
            900                 905                 910         


Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu 
        915                 920                 925             


Lys 
    


<210>  3222
<211>  924
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3222

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Met Lys 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Leu Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Leu Ser Glu His Ser Glu Tyr Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asp Asn Ser Lys Lys Val Tyr Arg Glu Cys Arg Glu Thr Leu 
305                 310                 315                 320 


Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile 
                325                 330                 335     


Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly 
            340                 345                 350         


Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu 
        355                 360                 365             


Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys 
    370                 375                 380                 


Ile Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser 
385                 390                 395                 400 


Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn 
                405                 410                 415     


Tyr Tyr Arg Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu 
            420                 425                 430         


Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu 
        435                 440                 445             


Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala 
    450                 455                 460                 


Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met 
465                 470                 475                 480 


Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp 
                485                 490                 495     


Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp 
            500                 505                 510         


Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp 
        515                 520                 525             


Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val 
    530                 535                 540                 


Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg 
545                 550                 555                 560 


Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys 
                565                 570                 575     


Pro Ala Ala Ser Pro Asn Val Thr Met Phe Arg Asp Ala Val Thr Ile 
            580                 585                 590         


Ile Arg Ile Asp Asp Lys Ser Thr Asp Asp Arg Ile Ser Glu Ile Leu 
        595                 600                 605             


Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile 
    610                 615                 620                 


Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr 
625                 630                 635                 640 


Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val 
                645                 650                 655     


Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr 
            660                 665                 670         


Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys 
        675                 680                 685             


Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe 
    690                 695                 700                 


Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu 
705                 710                 715                 720 


Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu 
                725                 730                 735     


Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His 
            740                 745                 750         


Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu 
        755                 760                 765             


Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu 
    770                 775                 780                 


Cys Glu Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys 
785                 790                 795                 800 


Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala 
                805                 810                 815     


Asp Ser Asn Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr 
            820                 825                 830         


Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp 
        835                 840                 845             


Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys 
    850                 855                 860                 


Arg Glu Asp Asp Thr Lys Gln Glu Glu Ile Ile Lys Tyr Glu Asp Asp 
865                 870                 875                 880 


Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn 
                885                 890                 895     


Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu 
            900                 905                 910         


Gln Leu Phe Glu Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 


<210>  3223
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3223

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Ile Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Pro Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn His Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3224
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3224

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Ile Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Pro Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn His Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3225
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3225

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys Arg Gly Asn Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Lys Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Ala Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Glu Arg Asp Lys Ser Pro Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Ile Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asn Asp Thr Lys Gln Glu Tyr Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  3226
<211>  954
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3226

Met Gly Lys Lys Ile His Ala Arg Asp Leu Arg Glu Gln Arg Lys Thr 
1               5                   10                  15      


Asp Arg Thr Glu Lys Phe Ala Asp Gln Asn Lys Lys Arg Glu Ala Glu 
            20                  25                  30          


Arg Ala Val Gln Lys Lys Asp Ala Ala Val Ser Val Lys Ser Val Ser 
        35                  40                  45              


Ser Val Ser Ser Lys Lys Asp Asn Val Thr Lys Ser Met Ala Lys Ala 
    50                  55                  60                  


Ala Gly Val Lys Ser Val Phe Ala Val Gly Asn Thr Val Tyr Met Thr 
65                  70                  75                  80  


Ser Phe Gly Arg Gly Asn Asp Ala Val Leu Glu Gln Lys Ile Val Asp 
                85                  90                  95      


Thr Ser His Glu Pro Leu Asn Ile Asp Asp Pro Ala Tyr Gln Leu Asn 
            100                 105                 110         


Val Val Thr Met Asn Gly Tyr Ser Val Thr Gly His Arg Gly Glu Thr 
        115                 120                 125             


Val Ser Ala Val Thr Asp Asn Pro Leu Arg Arg Phe Asn Gly Gly Lys 
    130                 135                 140                 


Lys Asp Glu Pro Glu Gln Ser Val Pro Thr Asp Met Leu Cys Leu Lys 
145                 150                 155                 160 


Pro Thr Leu Glu Lys Lys Phe Phe Gly Lys Glu Phe Asn Asp Asn Ile 
                165                 170                 175     


His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala 
            180                 185                 190         


Val Tyr Ser Thr Asn Ala Ile Tyr Ala Leu Asn Asn Met Ser Ala Asp 
        195                 200                 205             


Glu Asn Ile Glu Asn Ser Asp Phe Phe Met Lys Arg Thr Thr Asp Glu 
    210                 215                 220                 


Thr Phe Asp Asp Phe Glu Lys Lys Lys Glu Ser Thr Asn Ser Arg Glu 
225                 230                 235                 240 


Lys Ala Asp Phe Asp Ala Phe Glu Lys Phe Ile Gly Asn Tyr Arg Leu 
                245                 250                 255     


Ala Tyr Phe Ala Asp Ala Phe Tyr Val Asn Lys Lys Asn Pro Lys Gly 
            260                 265                 270         


Lys Ala Arg Asn Val Leu Arg Glu Asp Lys Glu Leu Tyr Ser Val Leu 
        275                 280                 285             


Thr Leu Ile Gly Lys Leu Arg His Trp Cys Val His Ser Glu Glu Gly 
    290                 295                 300                 


Arg Ala Glu Phe Trp Leu Tyr Lys Leu Asp Glu Leu Lys Asp Asp Phe 
305                 310                 315                 320 


Lys Asn Val Leu Asp Val Val Tyr Asn Arg Pro Val Glu Glu Ile Asn 
                325                 330                 335     


Asn Arg Phe Ile Glu Asn Asn Lys Val Asn Ile Gln Ile Leu Gly Ser 
            340                 345                 350         


Val Tyr Lys Asn Thr Asp Ile Ala Glu Leu Val Arg Ser Tyr Tyr Glu 
        355                 360                 365             


Phe Leu Ile Thr Lys Lys Tyr Lys Asn Met Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Ser Met Leu Glu Gly Lys Gly Tyr Ala Asp Lys Glu Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Asn Lys Leu Tyr Gln Met Thr Asp Phe Ile Leu Tyr 
                405                 410                 415     


Thr Gly Tyr Ile Asn Glu Asp Ser Asp Arg Ala Asp Asp Leu Val Asn 
            420                 425                 430         


Thr Leu Arg Ser Ser Leu Lys Glu Asp Asp Lys Thr Thr Val Tyr Cys 
        435                 440                 445             


Lys Glu Ala Asp Tyr Leu Trp Lys Lys Tyr Arg Glu Ser Ile Arg Glu 
    450                 455                 460                 


Val Ala Asp Ala Leu Asp Gly Asp Asn Ile Lys Arg Leu Ser Lys Ser 
465                 470                 475                 480 


Asn Ile Glu Ile Gln Glu Asp Lys Leu Arg Lys Cys Phe Ile Ser Tyr 
                485                 490                 495     


Ala Asp Ser Val Ser Glu Phe Thr Lys Leu Ile Tyr Leu Leu Thr Arg 
            500                 505                 510         


Phe Leu Ser Gly Lys Glu Ile Asn Asp Leu Val Thr Thr Leu Ile Asn 
        515                 520                 525             


Lys Phe Asp Asn Ile Arg Ser Phe Leu Glu Ile Met Asp Glu Leu Gly 
    530                 535                 540                 


Leu Asp Arg Thr Phe Thr Ala Glu Tyr Ser Phe Phe Glu Gly Ser Thr 
545                 550                 555                 560 


Lys Tyr Leu Ala Glu Leu Val Glu Leu Asn Ser Phe Val Lys Ser Cys 
                565                 570                 575     


Ser Phe Asp Ile Asn Ala Lys Arg Thr Met Tyr Arg Asp Ala Leu Asp 
            580                 585                 590         


Ile Leu Gly Ile Lys Ser Gly Lys Thr Glu Glu Asp Ile Glu Lys Met 
        595                 600                 605             


Ile Asp Asn Ile Leu Gln Ile Asp Ala Asn Gly Asp Lys Lys Leu Lys 
    610                 615                 620                 


Lys Asn Asn Gly Leu Arg Asn Phe Ile Ala Ser Asn Val Ile Asp Ser 
625                 630                 635                 640 


Asn Arg Phe Lys Tyr Leu Val Arg Tyr Gly Asn Pro Lys Lys Ile Arg 
                645                 650                 655     


Glu Thr Ala Lys Cys Lys Pro Ala Val Arg Phe Val Leu Asn Glu Ile 
            660                 665                 670         


Pro Asp Ala Gln Ile Glu Arg Tyr Tyr Glu Ala Cys Cys Pro Lys Asn 
        675                 680                 685             


Thr Ala Leu Cys Ser Ala Asn Lys Arg Arg Glu Lys Leu Ala Asp Met 
    690                 695                 700                 


Ile Ala Glu Ile Glu Phe Glu Asn Phe Ser Asp Ala Gly Asn Tyr Gln 
705                 710                 715                 720 


Lys Ala Asn Val Thr Ser Arg Thr Ser Glu Ala Glu Ile Lys Arg Lys 
                725                 730                 735     


Asn Gln Ala Ile Ile Arg Leu Tyr Leu Thr Val Met Tyr Ile Met Leu 
            740                 745                 750         


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Phe His Cys 
        755                 760                 765             


Val Glu Arg Asp Thr Lys Leu Tyr Ala Glu Ser Gly Leu Glu Val Gly 
    770                 775                 780                 


Asn Ile Glu Lys Asn Lys Thr Asn Leu Thr Met Ala Val Met Gly Val 
785                 790                 795                 800 


Lys Leu Glu Asn Gly Ile Ile Lys Thr Glu Phe Asp Lys Ser Leu Ala 
                805                 810                 815     


Glu Asn Ala Ala Asn Arg Tyr Leu Arg Asn Ala Arg Trp Tyr Lys Leu 
            820                 825                 830         


Ile Leu Asp Asn Leu Lys Lys Ser Glu Arg Ala Val Val Asn Glu Phe 
        835                 840                 845             


Arg Asn Thr Val Cys His Leu Asn Ala Ile Arg Asn Ile Asn Ile Asn 
    850                 855                 860                 


Ile Asp Gly Ile Lys Glu Val Glu Asn Tyr Phe Ala Leu Tyr His Tyr 
865                 870                 875                 880 


Leu Ile Gln Lys His Leu Glu Asn Arg Phe Ala Asp Lys Lys Val Glu 
                885                 890                 895     


Arg Asp Thr Gly Asp Phe Ile Ser Lys Leu Glu Glu His Lys Thr Tyr 
            900                 905                 910         


Cys Lys Asp Phe Val Lys Ala Tyr Cys Thr Pro Phe Gly Tyr Asn Leu 
        915                 920                 925             


Val Arg Tyr Lys Asn Leu Thr Ile Asp Gly Leu Phe Asp Lys Asn Tyr 
    930                 935                 940                 


Pro Gly Lys Asp Asp Ser Asp Glu Gln Lys 
945                 950                 


<210>  3227
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3227

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Val Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Glu Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Asp Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Lys 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Asp Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe Thr Asp 
    210                 215                 220                 


Pro Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Lys Val Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Arg Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3228
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3228

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asp Asn Asp Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asn 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Ser Val Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Gln Asn Thr Tyr Tyr Ile 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val 
            260                 265                 270         


Ser Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu 
    290                 295                 300                 


Tyr Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Val Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Ile Ala Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Leu Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Asn Arg Asp Glu Ser Pro Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asp Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  3229
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3229

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Asp Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Lys 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Leu Glu Asn Glu Ser Asn Asn Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe Thr Asp Pro 
    210                 215                 220                 


Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn Ile Lys Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu Tyr Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Ile Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Asp Asp Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ser Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Gly Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Lys Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Glu Asp Phe Lys Asp 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Met Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Tyr Ala Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asn Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3230
<211>  1057
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3230

Met Glu Glu Asn Lys Val Arg Phe Thr Asn Thr Ser Asn Val Lys Arg 
1               5                   10                  15      


Pro Lys Ser Leu Leu Lys Gln Met Gly His Lys Ser Thr Phe Leu Leu 
            20                  25                  30          


Asp Asp Thr Leu Ile Val Thr Ser Val Ala Lys Gly Lys Asn Glu Asp 
        35                  40                  45              


Gln Lys Gly Lys Glu Gln Ala Ala Ser Lys Ser Lys Val Ala Pro Gln 
    50                  55                  60                  


Ser His Ile Glu Leu Leu Ser Thr Ile Asp Gly Glu Val Leu Gly Gly 
65                  70                  75                  80  


Arg Lys Glu Leu Leu Ala Thr Thr Val Ser Arg Gln Glu Val Thr Ile 
                85                  90                  95      


Ser Gly Lys Ile Tyr Asn Leu Asn Thr Lys Thr Pro Glu Ser Thr Thr 
            100                 105                 110         


Val Thr Met Ala Asn Pro Ala Val Leu Leu Gln Lys Asn Ser Ser Thr 
        115                 120                 125             


Thr Gln Val Ala Arg Lys Thr Asp Tyr Leu Gly Ile Lys Ser Ala Leu 
    130                 135                 140                 


Glu Lys Glu Phe Phe Asn Asp Phe Ser Asn Ser Gly Phe Asn Asp Asn 
145                 150                 155                 160 


Val Arg Val Gln Ile Ala Tyr Asn Ile Leu Asp Ile Arg Lys Ile Leu 
                165                 170                 175     


Ala Thr Thr Ile Asn Asn Ile Val Ser Met Phe Tyr Asn Leu Asp Arg 
            180                 185                 190         


Thr Thr Gly Asp Ile Ala Asp Glu Thr Lys Lys Ser Thr Asn Thr Asp 
        195                 200                 205             


Ile Ile Gly Met Ile Lys Thr Tyr Leu Lys Tyr Asp Gln Ala Lys Asn 
    210                 215                 220                 


Ser Asn Asp Pro Ser Ile Lys Lys Thr Phe Asn Lys Ala Glu Glu Leu 
225                 230                 235                 240 


Leu Ile Asn Thr Lys Ala Tyr His Thr Tyr Phe Asp Arg Leu Phe Thr 
                245                 250                 255     


Thr Pro Thr Arg Gln Ala Phe Lys Ala Gly Lys Leu Lys Asp Thr Asn 
            260                 265                 270         


Asp Lys Lys Ser Asn Leu Pro Cys Glu Phe Ser Lys Leu Ser Glu Lys 
        275                 280                 285             


Asp Gln Glu Glu Phe Lys Asn Glu Ala Ile Thr His Asn Tyr Asp Val 
    290                 295                 300                 


Leu Arg Leu Leu Gly Leu Gly Arg Gln Leu Val Val His Glu Lys Tyr 
305                 310                 315                 320 


Lys Ser Asp Glu His Asn Lys Asp Asn Ser Ile Glu Ser Leu Phe Asn 
                325                 330                 335     


Ile Asp Lys Ile Ile Arg Asn Ser Asn Asp Thr Met Asp Leu Leu Lys 
            340                 345                 350         


Arg Leu Asp Asn Ile Tyr Leu Glu Ser Ala Glu Gln Ile Asp Asn Ser 
        355                 360                 365             


Phe Lys Lys Ser Ser Ala Thr Asn Cys Leu Ile Leu Glu Glu Leu Tyr 
    370                 375                 380                 


Lys Arg Ile Gly Lys Ala Lys Thr Gln Ala Glu Leu Tyr Lys Asp Tyr 
385                 390                 395                 400 


Tyr Arg Tyr Ala Ile Leu Lys Glu Asp Gln Cys Leu Gly Ile Ser Phe 
                405                 410                 415     


Asn Arg Ile Lys Glu Ala Val Leu Glu Lys Leu Lys Glu Glu Gln Arg 
            420                 425                 430         


Tyr Lys Asn Phe Glu Tyr Arg Asn Asp Asn Lys Arg Phe Tyr Thr Leu 
        435                 440                 445             


Cys Asn Phe Val Leu Trp His Tyr Met Val Asp Leu Arg Asp Arg Asn 
    450                 455                 460                 


Glu Thr Arg Ala Gly His Gln Gln Thr Asp Arg Asn Glu Ile Glu Glu 
465                 470                 475                 480 


Leu Lys Ser Lys Leu Arg Ala Cys Cys Asp Asn Asn Gly Asp Gly Gly 
                485                 490                 495     


Glu Asn Gln Lys Tyr Ala Ile Tyr Lys Glu Phe Val Asn Phe His Trp 
            500                 505                 510         


Thr Asp Leu Arg Thr Ser Ile Asn Thr Leu Tyr Asp Leu Cys Val Lys 
        515                 520                 525             


Tyr Lys Tyr Thr Ala Lys Asn Tyr Arg Ile Asp Ser Lys Ile Gln Ile 
    530                 535                 540                 


Asp Asn Gln Leu Ser Ser Ser Ala Asn Asn Val Lys Thr Phe Val Lys 
545                 550                 555                 560 


Tyr Ile Tyr Phe Leu Ser Glu Phe Leu Asp Gly Lys Glu Val Asn Val 
                565                 570                 575     


Phe Phe Asn Glu Leu Val Glu Lys Phe Ser Asn Ile Ala Glu Ile Val 
            580                 585                 590         


Thr Thr Val Asn Asp Asn Ile Asn Asn Ser Ser Lys Lys Ser Pro Asn 
        595                 600                 605             


Ile Ser Phe Leu Pro Gln Tyr Ser Leu Phe Gln Glu Ala Gly Thr Val 
    610                 615                 620                 


Ala Asp Gln Leu Arg Asn Ala Arg Asn Ile Lys His Ala Thr Leu Arg 
625                 630                 635                 640 


Ala Arg Ile Asn Asp Lys Val Ala Asp Lys Asp Ser Lys Met Ser Pro 
                645                 650                 655     


Ser Lys Gln Thr Ile Ser Asp Ala Leu Tyr Met Leu Ile Asp Glu Asn 
            660                 665                 670         


Asp Thr Ile Glu Asn Tyr Lys Gln Leu Ile Trp Asp Glu Lys Glu Ser 
        675                 680                 685             


Gly Thr Trp Val Lys Lys Ala Thr Gly Asn Asn Lys Val Arg Asn Phe 
    690                 695                 700                 


Ile Ile Asn Asn Ile Ile Met Ser Lys Trp Phe Met Tyr Ile Ser Lys 
705                 710                 715                 720 


Tyr Ser Asp Pro Arg Asn Cys Ser Lys Ile Met His Asn Lys Glu Ala 
                725                 730                 735     


Val Val Phe Ala Met Ser Ser Ile Pro Asp Ala Gln Ile Glu Lys Tyr 
            740                 745                 750         


Tyr Lys Arg Val Thr Ala Lys Ser Val Gln Tyr Gly Asn Lys Thr Ala 
        755                 760                 765             


Glu Glu Met Arg Ser Ile Val Ile Asp Ala Leu Met Asn Phe Ser Leu 
    770                 775                 780                 


Lys Pro Val Leu Thr Gly Val Ala Asn Asn Asp Tyr Ser Asn Glu Asn 
785                 790                 795                 800 


Arg Glu Arg Asp Ile Gly Ile Ile Gln Leu Tyr Leu Thr Val Ala Tyr 
                805                 810                 815     


Ile Val Thr Lys Ser Leu Val Asn Val Asn Lys Arg Phe Leu Leu Ala 
            820                 825                 830         


Phe Ser Cys Leu Glu Arg Asp Val Pro Leu Ile Leu Asn Gly Lys Ser 
        835                 840                 845             


Phe Lys Asp Ala Asn Ile Leu Val Leu Ser Glu Lys Phe Ile Ala Glu 
    850                 855                 860                 


Asp Gln Glu Ile Glu Gln Lys Tyr Lys Leu Ala Lys Lys Asn Arg Ile 
865                 870                 875                 880 


Thr Pro Asn Met Ser Lys Glu Asp Val Lys Asn Val Phe Lys Glu Leu 
                885                 890                 895     


Asn Ala Glu Tyr Lys Ser Lys His Tyr Ala Glu Ser Leu Thr Arg Pro 
            900                 905                 910         


Arg Asp Pro Asp Ser Lys Lys Asp Lys Ser Cys Ala Tyr Leu Val Asn 
        915                 920                 925             


Asn Leu Asn Glu Ala Lys Lys Ile Glu Asn Val Leu Met Asp Phe Lys 
    930                 935                 940                 


Asn Lys Val Asp His Leu Asn Val Val Lys Ser Ala Pro Glu Tyr Met 
945                 950                 955                 960 


Ser Asn Ile Lys Asn Ile Asp Ser Phe Tyr Gly Ile Phe Cys Phe Ala 
                965                 970                 975     


Leu Gln Asn Ile Leu Ala Asp Lys Met Ile Lys Trp Ser Val Asn Glu 
            980                 985                 990         


Lys Asn Ser Lys Glu Asp Val Glu  Ile Ile Asn Ser Tyr  Gly Gln Glu 
        995                 1000                 1005             


Leu Lys  Lys Lys Leu Asp Ser  Arg His Thr Phe Asp  Arg Asp Ala 
    1010                 1015                 1020             


Met Trp  Ile Ile Asn Met Pro  Phe Ala Tyr Asn Phe  Pro Arg Tyr 
    1025                 1030                 1035             


Lys Asn  Leu Ser Ser Glu Tyr  Leu Phe Tyr Asp Lys  Glu Tyr Glu 
    1040                 1045                 1050             


Lys Thr  Lys Lys 
    1055         


<210>  3231
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3231

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Thr Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Lys 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Asp Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Ile Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Ala Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Ala 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Ala Glu Lys 
        915                 920         


<210>  3232
<211>  918
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3232

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Gly Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Asn Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp 
    370                 375                 380                 


Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Gly Val Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ser Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu Arg 
785                 790                 795                 800 


Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr Arg 
                805                 810                 815     


Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu Lys 
            820                 825                 830         


Glu Tyr Ile Gly Asp Ile Cys Thr Val Asp Ser Tyr Phe Ser Ile Tyr 
        835                 840                 845             


His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr Lys 
    850                 855                 860                 


Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His Gly 
865                 870                 875                 880 


Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr Asn 
                885                 890                 895     


Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg Asn 
            900                 905                 910         


Glu Tyr Leu Thr Glu Lys 
        915             


<210>  3233
<211>  907
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3233

Val Arg Leu Arg Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn 
1               5                   10                  15      


Asn Asn Ala Val Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile 
            20                  25                  30          


Ala Pro Ala Ala Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met 
        35                  40                  45              


Lys Ser Ile Leu Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly 
    50                  55                  60                  


Lys Gly Asn Ser Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr 
65                  70                  75                  80  


Asn Gln Thr Gln Leu Ser Ser Asp Gly Ser Ser Asn Ile Glu Leu Arg 
                85                  90                  95      


Gly Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu 
            100                 105                 110         


Ser Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu 
        115                 120                 125             


Ser Ser Pro Val Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu 
    130                 135                 140                 


Lys Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu 
145                 150                 155                 160 


Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr 
                165                 170                 175     


Asn Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Asp Ser Glu 
            180                 185                 190         


Ser Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu 
        195                 200                 205             


Val Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly 
    210                 215                 220                 


Asn Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys 
225                 230                 235                 240 


Arg Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg 
                245                 250                 255     


Val Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val 
            260                 265                 270         


Gly Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp 
        275                 280                 285             


Glu Asp Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu 
    290                 295                 300                 


Thr Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly 
305                 310                 315                 320 


Phe Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met 
                325                 330                 335     


Lys Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile 
            340                 345                 350         


Val Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg 
        355                 360                 365             


Glu Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr 
    370                 375                 380                 


Asp Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe 
385                 390                 395                 400 


Cys Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg 
                405                 410                 415     


Lys Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala 
            420                 425                 430         


Asp Glu Ala Ser Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn 
        435                 440                 445             


Ile Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala 
    450                 455                 460                 


Asp Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala 
465                 470                 475                 480 


Ser Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe 
                485                 490                 495     


Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys 
            500                 505                 510         


Phe Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val 
        515                 520                 525             


Asp Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser 
    530                 535                 540                 


Gln Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met 
545                 550                 555                 560 


Arg Lys Pro Ala Ser Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu 
                565                 570                 575     


Thr Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu 
            580                 585                 590         


Ile Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn 
        595                 600                 605             


Phe Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile 
    610                 615                 620                 


Lys Tyr Ala Asn Ala Gln Lys Ile Arg Lys Val Ala Lys Asn Glu Lys 
625                 630                 635                 640 


Val Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg 
                645                 650                 655     


Tyr Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu 
            660                 665                 670         


Val Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp 
        675                 680                 685             


Asp Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala 
    690                 695                 700                 


Lys Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr 
705                 710                 715                 720 


Leu Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala 
                725                 730                 735     


Ile His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro 
            740                 745                 750         


Glu Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln 
        755                 760                 765             


Thr Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys 
    770                 775                 780                 


Asn Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp 
785                 790                 795                 800 


Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val 
                805                 810                 815     


Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser 
            820                 825                 830         


Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg 
        835                 840                 845             


Glu Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu 
    850                 855                 860                 


Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser 
865                 870                 875                 880 


Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln 
                885                 890                 895     


Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
            900                 905         


<210>  3234
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3234

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Lys Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asp Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asp Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Glu Gly Gly Asp Glu Ser 
        195                 200                 205             


His Asp Asp Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val 
    210                 215                 220                 


Phe Thr Asn Pro Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Lys Asn 
225                 230                 235                 240 


Ile Arg Lys Ser Leu Arg Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Leu Glu Ala Tyr Lys Lys Arg Val Tyr Tyr Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Cys Val Phe His Asp Leu Ser Glu His Ser Glu Tyr 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Asn Ser Lys Lys Val Tyr Arg Glu Cys 
305                 310                 315                 320 


Arg Glu Thr Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn 
                325                 330                 335     


Lys Asp Phe Ile Glu Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp 
            340                 345                 350         


Met Met Lys Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp 
        355                 360                 365             


Phe Ile Val Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys 
385                 390                 395                 400 


Gln Tyr Asp Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu 
                405                 410                 415     


Leu Phe Cys Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu 
            420                 425                 430         


Val Arg Lys Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile 
        435                 440                 445             


Tyr Ala Asp Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe 
    450                 455                 460                 


Glu Asn Ile Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly 
465                 470                 475                 480 


Lys Thr Asp Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys 
                485                 490                 495     


Asn Ala Ser Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr 
            500                 505                 510         


Tyr Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile 
        515                 520                 525             


Ser Lys Phe Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser 
    530                 535                 540                 


Ala Val Asp Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn 
545                 550                 555                 560 


Asp Ser Gln Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala 
                565                 570                 575     


Ser Met Arg Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp 
            580                 585                 590         


Ala Leu Thr Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile 
        595                 600                 605             


Ser Glu Ile Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu 
    610                 615                 620                 


Arg Asn Phe Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr 
625                 630                 635                 640 


Leu Ile Lys Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn 
                645                 650                 655     


Glu Lys Val Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile 
            660                 665                 670         


Glu Arg Tyr Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser 
        675                 680                 685             


Leu Glu Val Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser 
    690                 695                 700                 


Phe Asp Asp Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn 
705                 710                 715                 720 


Val Ala Lys Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val 
                725                 730                 735     


Met Tyr Leu Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val 
            740                 745                 750         


Ile Ala Ile His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile 
        755                 760                 765             


Ile Pro Glu Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu 
    770                 775                 780                 


Ser Gln Thr Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Asn Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asp Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  3235
<211>  923
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3235

Met Ala Lys Lys Asn Lys Ile Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Thr Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asn Ser Ser Asn Ile Glu Leu Arg Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Gly Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu His Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Asp Asp Tyr 
            340                 345                 350         


Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys 
        355                 360                 365             


Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met 
    370                 375                 380                 


Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val 
385                 390                 395                 400 


Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr 
                405                 410                 415     


Tyr Arg Asn Asp Val Ile Ala Gly Glu Ala Leu Val Arg Lys Leu Arg 
            420                 425                 430         


Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala 
        435                 440                 445             


Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp 
    450                 455                 460                 


His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp 
465                 470                 475                 480 


Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu 
                485                 490                 495     


Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly 
            500                 505                 510         


Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn 
        515                 520                 525             


Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu 
    530                 535                 540                 


Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile 
545                 550                 555                 560 


Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro 
                565                 570                 575     


Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu 
            580                 585                 590         


Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys 
        595                 600                 605             


Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr 
    610                 615                 620                 


Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala 
625                 630                 635                 640 


Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met 
                645                 650                 655     


Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys 
            660                 665                 670         


Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg 
        675                 680                 685             


Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys 
    690                 695                 700                 


Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg 
705                 710                 715                 720 


Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val 
                725                 730                 735     


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys 
            740                 745                 750         


Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala 
        755                 760                 765             


Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys 
    770                 775                 780                 


Glu Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys 
785                 790                 795                 800 


Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp 
                805                 810                 815     


Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val 
            820                 825                 830         


Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser 
        835                 840                 845             


Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg 
    850                 855                 860                 


Glu Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu 
865                 870                 875                 880 


Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser 
                885                 890                 895     


Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln 
            900                 905                 910         


Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920             


<210>  3236
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3236

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Val Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Met Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Glu Ser Ser Ser Asn Ile Lys Leu Cys Gly 
            100                 105                 110         


Val Thr Lys Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser 
        195                 200                 205             


His Asp Asp Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val 
    210                 215                 220                 


Phe Ile Asp Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn 
225                 230                 235                 240 


Val Arg Lys Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Asn Arg Val 
            260                 265                 270         


Ser Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asn Asn Ile Tyr Pro Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Gly 
        435                 440                 445             


Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Val Pro Asp Met Asn Ser Ser Leu Glu Ala 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Asp Arg Asp Lys Ser Pro Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  3237
<211>  920
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3237

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Gln Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Ser Ser Asn Ile Glu Leu Arg Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Lys Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe Thr Asn 
    210                 215                 220                 


Pro Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Lys Asn Ile Arg Lys 
225                 230                 235                 240 


Ser Leu Arg Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu His Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Asp Asp Tyr 
            340                 345                 350         


Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys 
        355                 360                 365             


Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met 
    370                 375                 380                 


Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val 
385                 390                 395                 400 


Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr 
                405                 410                 415     


Tyr Arg Asn Asp Val Ile Ala Gly Glu Ala Leu Val Arg Lys Leu Arg 
            420                 425                 430         


Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala 
        435                 440                 445             


Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp 
    450                 455                 460                 


His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp 
465                 470                 475                 480 


Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu 
                485                 490                 495     


Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly 
            500                 505                 510         


Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn 
        515                 520                 525             


Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu 
    530                 535                 540                 


Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile 
545                 550                 555                 560 


Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro 
                565                 570                 575     


Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu 
            580                 585                 590         


Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys 
        595                 600                 605             


Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr 
    610                 615                 620                 


Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala 
625                 630                 635                 640 


Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met 
                645                 650                 655     


Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys 
            660                 665                 670         


Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg 
        675                 680                 685             


Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys 
    690                 695                 700                 


Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg 
705                 710                 715                 720 


Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val 
                725                 730                 735     


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys 
            740                 745                 750         


Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala 
        755                 760                 765             


Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys 
    770                 775                 780                 


Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Arg Arg 
785                 790                 795                 800 


Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met 
                805                 810                 815     


Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu 
            820                 825                 830         


Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser 
        835                 840                 845             


Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp 
    850                 855                 860                 


Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn 
865                 870                 875                 880 


His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly 
                885                 890                 895     


Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp 
            900                 905                 910         


Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920 


<210>  3238
<211>  1011
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3238

Met Val Val Thr Tyr Leu Lys Trp Ile Ile Ile Leu Arg Glu Gly Thr 
1               5                   10                  15      


Met Lys Met Ala Lys Lys Lys Asn Ala Lys Gln Arg Arg Glu Glu Glu 
            20                  25                  30          


Lys Asn Arg Leu Lys Ala Lys Ile Glu Lys Phe Lys Ile Lys Tyr Ala 
        35                  40                  45              


Glu Gln Glu Thr Val Asp Lys Ile Thr Glu Glu Ile Ala Gln Ser Asp 
    50                  55                  60                  


Lys Ile Met Arg Thr Glu Ser Ile Leu Val Gln His Thr Lys Lys Ser 
65                  70                  75                  80  


Leu Ala Lys Ala Ser Gly Val Lys Ser Val Phe Ile Lys Asp Asp Glu 
                85                  90                  95      


Val Ile Met Thr Ser Phe Gly Arg Gly Asn Asp Ala Val Val Glu Lys 
            100                 105                 110         


Ile Ile Lys Asp Asn Asn Val Asp Glu Lys Asn Thr Lys Pro Ala Tyr 
        115                 120                 125             


Glu Ile Val Asp Ile Glu Lys Asn Gly Asp Leu Ile Lys Val Gln Ser 
    130                 135                 140                 


Arg Arg Cys Lys Asn Ile Glu Ser Ala Asn Thr Glu Leu Pro Pro Glu 
145                 150                 155                 160 


Lys Ile Gly Met Asp Leu Ile Arg Cys Lys Asp Lys Leu Glu Glu Ile 
                165                 170                 175     


Tyr Phe Gly Arg Thr Phe Asn Asp Asn Ile His Ile Gln Leu Ile Tyr 
            180                 185                 190         


Asn Ile Leu Asp Ile Glu Lys Ile Leu Ser Val Tyr Ile Asn Asn Ala 
        195                 200                 205             


Val Tyr Ala Leu Gly Asn Leu Glu Arg Lys Glu Asn Asp Lys Glu Lys 
    210                 215                 220                 


Asp Leu Val Gly Tyr Leu Ser Ala Arg Ala Gly Tyr Asn Lys Val Ile 
225                 230                 235                 240 


Asn Lys Ala Ile Asn Asp Glu Lys Ile Lys Asp Arg Ile Glu Asp Leu 
                245                 250                 255     


Lys Glu Phe Ile Glu Asn Gly Asn Arg Leu Gly Tyr Phe Gly Asp Ile 
            260                 265                 270         


Phe Phe Lys Lys Glu Glu Val Ser Lys Asn Gly Lys Lys Pro Lys Lys 
        275                 280                 285             


Val Glu Val Leu Lys Ser Glu Lys Glu Ile Phe Asp Ile Leu Ala Leu 
    290                 295                 300                 


Leu Gly Ser Leu Arg Gln Phe Cys Phe His Tyr Asp Glu Ala Val Phe 
305                 310                 315                 320 


Glu Asn Glu Asp Gly Val Ile Asp Lys Glu Tyr Asn Asp Asn Ser Trp 
                325                 330                 335     


Leu Tyr Asn Leu Glu Lys Leu Glu Pro Glu Phe Lys Asp Thr Leu Asp 
            340                 345                 350         


Tyr Phe Tyr Asn Arg Lys Ile Asn Asp Ile Asn Lys Gly Phe Ile Lys 
        355                 360                 365             


Thr Asn Gln Ile Asn Leu His Ile Ile Cys Asp Glu Leu Gly Leu Asn 
    370                 375                 380                 


Trp Asp Lys Glu Gln Val Val Gly Asp Tyr Tyr Asp Phe Leu Ile Ala 
385                 390                 395                 400 


Lys Lys Tyr Lys Asn Ile Gly Phe Ser Ile Lys Lys Ile Arg Glu His 
                405                 410                 415     


Met Phe Asp Ile Tyr Glu Ala Phe Asp Ile Lys Asp Lys Arg Phe Asp 
            420                 425                 430         


Ser Val Arg Ser Ile Met Tyr Lys Ile Ile Asp Phe Val Ile Tyr Tyr 
        435                 440                 445             


Ser Phe Ile His Tyr Lys Gln Asp Glu Val Asp Glu Ile Val Asn Tyr 
    450                 455                 460                 


Leu Arg Ser Thr Leu Ser Glu Glu Gln Lys Lys Glu Lys Tyr Ile Lys 
465                 470                 475                 480 


Leu Ala Gly Asn Ile Trp Ala Glu Tyr Lys Thr Gln Phe Asn Lys Leu 
                485                 490                 495     


Lys Asp Ile Leu Leu Ala Asn Ile Lys Glu Phe Ser Asp Ala Lys Glu 
            500                 505                 510         


Asp Asp Val Tyr Tyr Glu Glu Phe Lys Asn Phe Lys Phe Asn Glu Val 
        515                 520                 525             


Gly Lys Glu Lys Leu Gly Glu Asn Ala Glu Tyr Phe Cys Lys Leu Met 
    530                 535                 540                 


Tyr Leu Leu Thr Leu Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu 
545                 550                 555                 560 


Thr Thr Leu Ile Asn Lys Phe Asp Asn Ile Arg Ser Phe Val Glu Leu 
                565                 570                 575     


Met Lys Glu Glu Asn Ile Glu Cys Ile Phe Asp Lys Lys Phe Ala Phe 
            580                 585                 590         


Phe Asp Glu Ser Lys Asn Val Cys Ser Thr Leu Arg Glu Ile Asn Ser 
        595                 600                 605             


Phe Ala Arg Met Gln Lys Pro Leu Asn Asn Val Ser Val Lys Arg Glu 
    610                 615                 620                 


Met Tyr Lys Asp Ala Ile Lys Ile Leu Leu Lys Asp Thr Arg Ala Glu 
625                 630                 635                 640 


Glu Gln Asn Ile Asp Arg Ile Leu Asn Glu Tyr Ile Pro Ser Lys Glu 
                645                 650                 655     


Asp Lys Gly Ile Lys Lys Asp Phe Arg Asn Phe Ile Ile Lys Asn Ile 
            660                 665                 670         


Ile Lys Ser Asn Arg Phe Met Tyr Leu Val Lys Tyr Ser Asn Pro Thr 
        675                 680                 685             


Asp Val Arg Asn Leu Ala Ser Asn Arg Asn Val Val Lys Phe Val Leu 
    690                 695                 700                 


Asn Ala Ile Pro Asp Thr Gln Ile Asp Arg Tyr Tyr Lys Ser Cys Ile 
705                 710                 715                 720 


Gln His Tyr Ser Asn Glu Val Asp Lys Glu Thr Gln Ile Gln Glu Leu 
                725                 730                 735     


Thr Asp Ile Ile Thr Gly Ile Asp Tyr Leu Asp Phe Leu Asp Val Arg 
            740                 745                 750         


Gln Ser Tyr Arg Asn Glu Asp Lys Ser Lys Lys Gln Ala Val Val Thr 
        755                 760                 765             


Leu Tyr Leu Thr Ile Leu Tyr Ile Leu Thr Lys Asn Leu Val Asn Val 
    770                 775                 780                 


Asn Ser Arg Tyr Val Ile Ala Leu His Cys Leu Glu Arg Asp Ser Lys 
785                 790                 795                 800 


Leu Tyr Gly Tyr Thr Lys Leu Ser Lys Lys Asn Asn Lys Lys Leu Glu 
                805                 810                 815     


Lys Ile Lys Pro Pro Lys Tyr His Glu Leu Thr Lys Tyr Phe Ile Asp 
            820                 825                 830         


Asn Arg Tyr Phe Asp Arg Lys Lys Lys Asn Lys Lys Tyr Gly Glu Tyr 
        835                 840                 845             


Thr Ser Lys Lys Ile Ser Thr Tyr Ile Glu Thr Asn Met Lys Asn Phe 
    850                 855                 860                 


Ile Gly Cys Glu Gln Phe Arg Thr Pro Glu Arg Tyr Arg Asp Thr Gln 
865                 870                 875                 880 


Ile Asp Met Phe Val Lys Tyr Arg Asn Ser Ile Ala His Leu Asn Ala 
                885                 890                 895     


Val Arg Lys Ala Ser Lys Tyr Ile Asn Asp Ile Arg Gly Phe Asp Thr 
            900                 905                 910         


Tyr Phe Glu Leu Tyr His Tyr Ile Met Gln Arg Asp Leu Lys Asp Ile 
        915                 920                 925             


Leu Glu Lys Ile Ala Glu Gly Ala Ala Lys Glu Thr Glu Glu Gly Gln 
    930                 935                 940                 


Lys Gln Asp Glu Leu Leu Lys Thr Tyr Phe Asp Asn Leu Asp Lys Tyr 
945                 950                 955                 960 


Gly Thr Tyr Val Lys Asp Phe Val Lys Ala Leu Asn Ile Pro Phe Ala 
                965                 970                 975     


Tyr Asn Tyr Pro Arg Tyr Lys Asn Leu Ser Ile Asp Glu Leu Phe Asp 
            980                 985                 990         


Lys Asn Asn Thr Arg Lys Thr Ile  Lys Ile Gln Asp Lys  Lys Leu Glu 
        995                 1000                 1005             


Glu Arg  Thr 
    1010     


<210>  3239
<211>  939
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3239

Met Ala Lys Lys Lys Arg Ile Thr Ala Lys Glu Arg Lys Gln Asn His 
1               5                   10                  15      


Arg Glu Ser Leu Met Lys Lys Ala Asp Ser Asn Ala Glu Lys Glu Lys 
            20                  25                  30          


Ala Lys Lys Pro Val Val Glu Asn Lys Pro Asp Thr Ala Ile Ser Lys 
        35                  40                  45              


Asp Asn Ile Pro Lys Pro Asn Lys Glu Ile Lys Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Ala Gly Val Lys Trp Val Ile Lys Ala Asn Asp Asp Val Ala Tyr 
65                  70                  75                  80  


Ile Ser Ser Phe Gly Lys Gly Asn Asn Ser Val Leu Glu Lys Arg Ile 
                85                  90                  95      


Met Gly Asp Val Ser Ser Asn Val Asn Lys Asp Ser His Met Tyr Val 
            100                 105                 110         


Asn Pro Lys Tyr Thr Lys Lys Asn Tyr Glu Ile Lys Asn Gly Phe Ser 
        115                 120                 125             


Ser Gly Ser Ser Leu Val Thr Tyr Pro Asn Lys Pro Asp Lys Asn Ser 
    130                 135                 140                 


Gly Met Asp Ala Leu Cys Leu Lys Pro Tyr Phe Glu Lys Asp Phe Phe 
145                 150                 155                 160 


Gly His Ile Phe Thr Asp Asn Met His Ile Gln Ala Ile Tyr Asn Ile 
                165                 170                 175     


Phe Asp Ile Glu Lys Ile Leu Ala Lys His Ile Thr Asn Ile Ile Tyr 
            180                 185                 190         


Thr Val Asn Ser Phe Asp Arg Asn Tyr Asn Gln Ser Gly Asn Asp Thr 
        195                 200                 205             


Ile Gly Phe Asp Ile Asn Tyr Arg Val Pro Tyr Ser Glu Tyr Gly Gly 
    210                 215                 220                 


Gly Lys Asp Ser Asn Gly Glu Pro Lys Asn Lys Ser Lys Trp Glu Lys 
225                 230                 235                 240 


Arg Lys Asn Phe Ile Lys Phe Tyr Asn Lys Ser Lys Pro His Leu Gly 
                245                 250                 255     


Tyr Tyr Glu Asn Ile Phe Tyr Asp His Gly Glu Pro Ile Ser Glu Glu 
            260                 265                 270         


Lys Phe Tyr Asn Tyr Leu Asn Ile Leu Asn Phe Ile Arg Asn Asn Thr 
        275                 280                 285             


Phe His Tyr Lys Asn Asp Asp Ile Glu Leu Tyr Ser Glu Asn Tyr Ser 
    290                 295                 300                 


Glu Glu Phe Val Phe Ile Asn Cys Leu Asn Lys Phe Val Lys Asn Lys 
305                 310                 315                 320 


Phe Lys Asn Val Asn Lys Asn Phe Ile Ser Asn Glu Lys Asn Asn Leu 
                325                 330                 335     


Tyr Ile Ile Leu Asn Ala Tyr Gly Lys Asp Thr Glu Asn Val Glu Val 
            340                 345                 350         


Val Lys Lys Tyr Ser Lys Glu Leu Tyr Lys Leu Ser Val Leu Lys Thr 
        355                 360                 365             


Asn Lys Asn Leu Gly Val Asn Val Lys Lys Leu Arg Glu Ser Ala Ile 
    370                 375                 380                 


Glu Tyr Gly Tyr Cys Pro Leu Pro Tyr Asp Lys Glu Lys Glu Val Ala 
385                 390                 395                 400 


Lys Leu Ser Ser Ile Lys His Lys Leu Tyr Lys Thr Tyr Asp Phe Val 
                405                 410                 415     


Ile Thr His Tyr Leu Asn Ser Asn Asp Lys Leu Leu Leu Glu Ile Val 
            420                 425                 430         


Glu Ala Leu Arg Leu Ser Lys Asn Asp Asp Glu Lys Glu Asn Val Tyr 
        435                 440                 445             


Lys Lys Tyr Ala Glu Lys Leu Phe Lys Ala Asp Asp Val Ile Asn Pro 
    450                 455                 460                 


Ile Lys Ala Ile Ser Lys Leu Phe Ala Glu Lys Gly Asn Lys Leu Phe 
465                 470                 475                 480 


Lys Glu Met Val Ile Ile Lys Lys Glu Tyr Val Glu Asp Ile Ser Ile 
                485                 490                 495     


Asp Lys Asn Ile Tyr Asp Phe Thr Lys Val Ile Phe Phe Met Thr Cys 
            500                 505                 510         


Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Asn Ile Ile Ser 
        515                 520                 525             


Lys Leu Gln Val Ile Glu Asp His Asn Asn Val Ile Lys Phe Ile Ser 
    530                 535                 540                 


Asn Asn Lys Asp Ala Val Tyr Lys Asp Tyr Ser Asp Lys Tyr Ala Ile 
545                 550                 555                 560 


Phe Arg Asn Ala Gly Lys Ile Ala Thr Glu Leu Glu Ala Ile Lys Ser 
                565                 570                 575     


Ile Val Arg Met Glu Asn Lys Ile Glu Asn Ala Pro Gln Glu Pro Leu 
            580                 585                 590         


Leu Lys Asp Ala Leu Leu Ser Leu Gly Val Ser Asp Asp Thr Lys Val 
        595                 600                 605             


Leu Glu Asn Thr Tyr Lys Lys Tyr Phe Asp Ser Lys Glu Lys Ala Asp 
    610                 615                 620                 


Lys Gln Ser Gln Lys Val Ser Thr Phe Leu Met Asn Asn Val Ile Asn 
625                 630                 635                 640 


Asn Asn Arg Phe Lys Tyr Val Ile Lys Tyr Ile Asn Pro Ala Asp Ile 
                645                 650                 655     


Asn Gly Leu Ala Lys Asn Arg Tyr Leu Val Lys Phe Val Leu Ser Asn 
            660                 665                 670         


Ile Pro Glu Glu Gln Ile Asp Ser Tyr Tyr Lys Leu Phe Ser Asn Glu 
        675                 680                 685             


Glu Glu Pro Ser Cys Glu Glu Lys Ile Lys Leu Leu Thr Lys Lys Ile 
    690                 695                 700                 


Ser Lys Leu Asn Phe Gln Thr Leu Phe Glu Asn Asn Lys Ile Pro Asn 
705                 710                 715                 720 


Val Glu Lys Glu Arg Lys Lys Ala Ile Ile Thr Leu Tyr Phe Thr Ile 
                725                 730                 735     


Val Tyr Ile Leu Val Lys Asn Leu Val Asn Ile Asn Gly Leu Tyr Thr 
            740                 745                 750         


Leu Ala Leu Tyr Phe Val Glu Arg Asp Gly Tyr Phe Tyr Lys Asp Ile 
        755                 760                 765             


Cys Gly Lys Lys Asp Lys Lys Lys Ser Tyr Asn Gly Val Asp Tyr Leu 
    770                 775                 780                 


Leu Leu Pro Glu Ile Phe Ser Gly Ser Lys Tyr Arg Glu Gln Thr Lys 
785                 790                 795                 800 


Asn Leu Lys Leu Pro Lys Glu Lys Asp Arg Asp Ile Met Lys Lys Tyr 
                805                 810                 815     


Leu Pro Asn Asp Lys Asp Arg Glu Gly Tyr Asn Lys Phe Phe Arg Ala 
            820                 825                 830         


Tyr Arg Asn Asn Ile Val His Leu Asn Ile Ile Ala Lys Leu Ser Glu 
        835                 840                 845             


Leu Thr Ser Asn Ile Asp Lys Asp Ile Asn Ser Tyr Phe Asp Ile Tyr 
    850                 855                 860                 


His Tyr Cys Thr Gln Arg Val Met Phe Asn Tyr Cys Lys Glu Asn Asn 
865                 870                 875                 880 


Asn Ile Val Leu Ala Lys Met Lys Asp Leu Ala His Ile Lys Ser Asp 
                885                 890                 895     


Cys Asp Glu Phe Ser Ser Lys His Thr Tyr Pro Phe Ser Ser Ala Val 
            900                 905                 910         


Leu Arg Phe Met Asn Leu Pro Phe Ala Tyr Asn Val Pro Arg Phe Lys 
        915                 920                 925             


Asn Leu Ser Tyr Lys Lys Phe Phe Asp Lys Gln 
    930                 935                 


<210>  3240
<211>  996
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic


<220>
<221>  misc_feature
<222>  (88)..(110)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (497)..(524)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (733)..(759)
<223>  Xaa can be any naturally occurring amino acid

<400>  3240

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
                85                  90                  95      


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Val 
            100                 105                 110         


Asp Asn Asn Val Tyr Asn Gln Thr Gln Leu Ser Ser Lys Gly Ser Ser 
        115                 120                 125             


Asn Ile Lys Leu Cys Gly Val Asn Glu Val Asn Ile Thr Phe Ser Ser 
    130                 135                 140                 


Lys His Gly Phe Glu Ser Gly Val Glu Ile Asn Thr Ser Asn Pro Thr 
145                 150                 155                 160 


His Arg Ser Gly Glu Ser Ser Pro Val Arg Gly Asp Met Leu Gly Leu 
                165                 170                 175     


Lys Ser Glu Leu Glu Lys Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn 
            180                 185                 190         


Ile His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu 
        195                 200                 205             


Ala Val Tyr Val Thr Asn Ile Val Tyr Ala Leu Asn Asn Met Leu Gly 
    210                 215                 220                 


Glu Gly Asp Asp Glu Ser His Asp Asp Phe Met Gly Tyr Leu Ser Ala 
225                 230                 235                 240 


Gln Asn Thr Tyr Tyr Ile Phe Thr His Pro Asp Lys Ser Asn Leu Ser 
                245                 250                 255     


Asp Lys Val Lys Gly Asn Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp 
            260                 265                 270         


Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys 
        275                 280                 285             


Thr Lys Asp Lys Arg Val Ser Glu Ala Tyr Lys Lys Arg Val Tyr His 
    290                 295                 300                 


Met Leu Ala Ile Val Gly Gln Ile Arg Gln Ser Val Phe His Asp Lys 
305                 310                 315                 320 


Ser Asn Glu Leu Asp Glu Tyr Leu Tyr Ser Phe Ile Asp Ile Ile Asp 
                325                 330                 335     


Ser Glu Tyr Arg Asp Thr Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp 
            340                 345                 350         


Ser Ile Asn Lys Gly Phe Val Gln Gly Asn Lys Val Asn Ile Ser Leu 
        355                 360                 365             


Leu Ile Asp Met Met Lys Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu 
    370                 375                 380                 


Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser 
385                 390                 395                 400 


Ile Lys Lys Leu Arg Glu Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe 
                405                 410                 415     


Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser Lys Met Tyr Lys Leu Met 
            420                 425                 430         


Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg Asn Asp Val Ala Ala Gly 
        435                 440                 445             


Glu Val Leu Val Arg Lys Leu Arg Phe Ser Met Thr Asp Asp Glu Lys 
    450                 455                 460                 


Glu Trp Ile Tyr Ala Asp Glu Ala Glu Lys Leu Trp Gly Lys Phe Arg 
465                 470                 475                 480 


Asn Asp Phe Glu Asn Ile Ala Asp His Met Asn Gly Asp Val Ile Lys 
                485                 490                 495     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            500                 505                 510         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Lys Ala Asp 
        515                 520                 525             


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
    530                 535                 540                 


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
545                 550                 555                 560 


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
                565                 570                 575     


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
            580                 585                 590         


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
        595                 600                 605             


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
    610                 615                 620                 


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
625                 630                 635                 640 


Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile 
                645                 650                 655     


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
            660                 665                 670         


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
        675                 680                 685             


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val 
    690                 695                 700                 


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
705                 710                 715                 720 


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Xaa Xaa Xaa Xaa 
                725                 730                 735     


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 
            740                 745                 750         


Xaa Xaa Xaa Xaa Xaa Xaa Xaa Lys Arg Ser Glu Leu Ala Arg Met Ile 
        755                 760                 765             


Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val Lys Gln Gln Ala Lys 
    770                 775                 780                 


Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys Ala Val Ile Gly Leu 
785                 790                 795                 800 


Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn Leu Val Asn Val Asn 
                805                 810                 815     


Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu Arg Asp Phe Gly Leu 
            820                 825                 830         


Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys Asn Leu Lys Asn Asp 
        835                 840                 845             


Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu Cys Asp Asp Arg Asp 
    850                 855                 860                 


Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn Arg Arg Leu Arg Lys Cys 
865                 870                 875                 880 


Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr Arg Lys Tyr 
                885                 890                 895     


Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu Lys Glu Tyr 
            900                 905                 910         


Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile Tyr His Tyr 
        915                 920                 925             


Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp Asp Thr Lys Gln Glu 
    930                 935                 940                 


Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His Gly Tyr Thr 
945                 950                 955                 960 


Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr Asn Ile Pro 
                965                 970                 975     


Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg Asn Glu Tyr 
            980                 985                 990         


Leu Thr Glu Lys 
        995     


<210>  3241
<211>  939
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3241

Met Ala Lys Lys Lys Arg Ile Thr Ala Lys Glu Arg Lys Gln Asn His 
1               5                   10                  15      


Arg Glu Ser Leu Met Lys Lys Ala Asp Ser Asn Ala Glu Lys Glu Lys 
            20                  25                  30          


Ala Lys Lys Pro Val Val Glu Asn Lys Pro Asp Thr Ala Ile Ser Lys 
        35                  40                  45              


Asp Asn Ile Pro Lys Pro Asn Lys Glu Ile Lys Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Ala Gly Val Lys Trp Val Ile Lys Ala Asn Asp Asp Val Ala Tyr 
65                  70                  75                  80  


Ile Ser Ser Phe Gly Lys Gly Asn Asn Ser Val Leu Glu Lys Arg Ile 
                85                  90                  95      


Met Gly Asp Val Ser Ser Asn Val Asn Lys Asp Ser His Met Tyr Val 
            100                 105                 110         


Asn Pro Lys Tyr Thr Lys Lys Asn Tyr Glu Ile Lys Asn Gly Phe Ser 
        115                 120                 125             


Ser Gly Ser Ser Leu Val Thr Tyr Pro Asn Lys Pro Asp Lys Asn Ser 
    130                 135                 140                 


Gly Met Asp Ala Leu Cys Leu Lys Pro Tyr Phe Glu Lys Asp Phe Phe 
145                 150                 155                 160 


Gly His Ile Phe Thr Asp Asn Met His Ile Gln Ala Ile Tyr Asn Ile 
                165                 170                 175     


Phe Asp Ile Glu Lys Ile Leu Ala Lys His Ile Thr Asn Ile Ile Tyr 
            180                 185                 190         


Thr Val Asn Ser Phe Asp Arg Asn Tyr Asn Gln Ser Gly Asn Asp Thr 
        195                 200                 205             


Ile Gly Phe Asp Ile Asn Tyr Arg Val Pro Tyr Ser Glu Tyr Gly Gly 
    210                 215                 220                 


Gly Lys Asp Ser Asn Gly Glu Pro Lys Asn Lys Ser Lys Trp Glu Lys 
225                 230                 235                 240 


Arg Lys Asn Phe Ile Lys Phe Tyr Asn Lys Ser Lys Pro His Leu Gly 
                245                 250                 255     


Tyr Tyr Glu Asn Ile Phe Tyr Asp His Gly Glu Pro Ile Ser Glu Glu 
            260                 265                 270         


Lys Phe Tyr Asn Tyr Leu Asn Ile Leu Asn Phe Ile Arg Asn Asn Thr 
        275                 280                 285             


Phe His Tyr Lys Asn Asp Asp Ile Glu Leu Tyr Ser Glu Asn Tyr Ser 
    290                 295                 300                 


Glu Glu Phe Val Phe Ile Asn Cys Leu Asn Lys Phe Val Lys Asn Lys 
305                 310                 315                 320 


Phe Lys Asn Val Asn Lys Asn Phe Ile Ser Asn Glu Lys Asn Asn Leu 
                325                 330                 335     


Tyr Ile Ile Leu Asn Ala Tyr Gly Lys Asp Thr Glu Asn Val Glu Val 
            340                 345                 350         


Val Lys Lys Tyr Ser Lys Glu Leu Tyr Lys Leu Ser Val Leu Lys Thr 
        355                 360                 365             


Asn Lys Asn Leu Gly Val Asn Val Lys Lys Leu Arg Glu Ser Ala Ile 
    370                 375                 380                 


Glu Tyr Gly Tyr Cys Pro Leu Pro Tyr Asp Lys Glu Lys Glu Val Ala 
385                 390                 395                 400 


Lys Leu Ser Ser Ile Lys His Lys Leu Tyr Lys Thr Tyr Asp Phe Val 
                405                 410                 415     


Ile Thr His Tyr Leu Asn Ser Asn Asp Lys Leu Leu Leu Glu Ile Val 
            420                 425                 430         


Glu Ala Leu Arg Leu Ser Lys Asn Asp Asp Glu Lys Glu Asn Val Tyr 
        435                 440                 445             


Lys Lys Tyr Ala Glu Lys Leu Phe Lys Ala Asp Asp Val Ile Asn Pro 
    450                 455                 460                 


Ile Lys Ala Ile Ser Lys Leu Phe Ala Glu Lys Gly Asn Lys Leu Phe 
465                 470                 475                 480 


Lys Glu Met Val Ile Ile Lys Lys Glu Tyr Val Glu Asp Ile Ser Ile 
                485                 490                 495     


Asp Lys Asn Ile Tyr Asp Phe Thr Lys Val Ile Phe Phe Met Thr Cys 
            500                 505                 510         


Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Asn Ile Ile Ser 
        515                 520                 525             


Lys Leu Gln Val Ile Glu Asp His Asn Asn Val Ile Lys Phe Ile Ser 
    530                 535                 540                 


Asn Asn Lys Asp Ala Val Tyr Lys Asp Tyr Ser Asp Lys Tyr Ala Ile 
545                 550                 555                 560 


Phe Arg Asn Ala Gly Lys Ile Ala Thr Glu Leu Glu Ala Ile Lys Ser 
                565                 570                 575     


Ile Val Arg Met Glu Asn Lys Ile Glu Asn Ala Pro Gln Glu Pro Leu 
            580                 585                 590         


Leu Lys Asp Ala Leu Leu Ser Leu Gly Val Ser Asp Asp Thr Lys Val 
        595                 600                 605             


Leu Glu Asn Thr Tyr Lys Lys Tyr Phe Asp Ser Lys Glu Lys Ala Asp 
    610                 615                 620                 


Lys Gln Ser Gln Lys Val Ser Thr Phe Leu Met Asn Asn Val Ile Asn 
625                 630                 635                 640 


Asn Asn Arg Phe Lys Tyr Val Ile Lys Tyr Ile Asn Pro Ala Asp Ile 
                645                 650                 655     


Asn Gly Leu Ala Lys Asn Arg Tyr Leu Val Lys Phe Val Leu Ser Asn 
            660                 665                 670         


Ile Pro Glu Glu Gln Ile Asp Ser Tyr Tyr Lys Leu Phe Ser Asn Glu 
        675                 680                 685             


Glu Glu Pro Ser Cys Glu Glu Lys Ile Lys Leu Leu Thr Lys Lys Ile 
    690                 695                 700                 


Ser Lys Leu Asn Phe Gln Thr Leu Phe Glu Asn Asn Lys Ile Pro Asn 
705                 710                 715                 720 


Val Glu Lys Glu Arg Lys Lys Ala Ile Ile Thr Leu Tyr Phe Thr Ile 
                725                 730                 735     


Val Tyr Ile Leu Val Lys Asn Leu Val Asn Ile Asn Gly Leu Tyr Thr 
            740                 745                 750         


Leu Ala Leu Tyr Phe Val Glu Arg Asp Gly Tyr Phe Tyr Lys Asp Ile 
        755                 760                 765             


Cys Gly Lys Lys Asp Lys Lys Lys Ser Tyr Asn Gly Val Asp Tyr Leu 
    770                 775                 780                 


Leu Leu Pro Glu Ile Phe Ser Gly Ser Lys Tyr Arg Glu Gln Thr Lys 
785                 790                 795                 800 


Asn Leu Lys Leu Pro Lys Glu Lys Asp Arg Asp Ile Met Lys Lys Tyr 
                805                 810                 815     


Leu Pro Asn Asp Lys Asp Arg Glu Gly Tyr Asn Lys Phe Phe Arg Ala 
            820                 825                 830         


Tyr Arg Asn Asn Ile Val His Leu Asn Ile Ile Ala Lys Leu Ser Glu 
        835                 840                 845             


Leu Thr Ser Asn Ile Asp Lys Asp Ile Asn Ser Tyr Phe Asp Ile Tyr 
    850                 855                 860                 


His Tyr Cys Thr Gln Arg Val Met Phe Asn Tyr Cys Lys Glu Asn Asn 
865                 870                 875                 880 


Asn Ile Val Leu Ala Lys Met Lys Asp Leu Ala His Ile Lys Ser Asp 
                885                 890                 895     


Cys Asp Glu Phe Ser Ser Lys His Thr Tyr Pro Phe Ser Ser Ala Val 
            900                 905                 910         


Leu Arg Phe Met Asn Leu Pro Phe Ala Tyr Asn Val Pro Arg Phe Lys 
        915                 920                 925             


Asn Leu Ser Tyr Lys Lys Phe Phe Asp Lys Gln 
    930                 935                 


<210>  3242
<211>  923
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3242

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Val Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Glu Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asn Ser Ser Asn Ile Glu Leu Arg Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Gly Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu His Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Asp Asp Tyr 
            340                 345                 350         


Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys 
        355                 360                 365             


Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met 
    370                 375                 380                 


Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val 
385                 390                 395                 400 


Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr 
                405                 410                 415     


Tyr Arg Asn Asp Val Ile Ala Gly Glu Ala Leu Val Arg Lys Leu Arg 
            420                 425                 430         


Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala 
        435                 440                 445             


Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp 
    450                 455                 460                 


His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp 
465                 470                 475                 480 


Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu 
                485                 490                 495     


Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly 
            500                 505                 510         


Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn 
        515                 520                 525             


Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn Val Glu 
    530                 535                 540                 


Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile 
545                 550                 555                 560 


Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro 
                565                 570                 575     


Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu 
            580                 585                 590         


Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys 
        595                 600                 605             


Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr 
    610                 615                 620                 


Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala 
625                 630                 635                 640 


Asn Ala Gln Lys Ile Arg Lys Val Ala Glu Asn Glu Lys Val Val Met 
                645                 650                 655     


Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys 
            660                 665                 670         


Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg 
        675                 680                 685             


Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe Lys 
    690                 695                 700                 


Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg 
705                 710                 715                 720 


Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val 
                725                 730                 735     


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys 
            740                 745                 750         


Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala 
        755                 760                 765             


Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys 
    770                 775                 780                 


Glu Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys 
785                 790                 795                 800 


Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp 
                805                 810                 815     


Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val 
            820                 825                 830         


Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser 
        835                 840                 845             


Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg 
    850                 855                 860                 


Glu Asp Asp Lys Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu 
865                 870                 875                 880 


Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser 
                885                 890                 895     


Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln 
            900                 905                 910         


Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920             


<210>  3243
<211>  918
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3243

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Gly Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Asn Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp 
    370                 375                 380                 


Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Gly Val Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ser Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu Arg 
785                 790                 795                 800 


Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr Arg 
                805                 810                 815     


Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu Lys 
            820                 825                 830         


Glu Tyr Ile Gly Asp Ile Cys Thr Val Asp Ser Tyr Phe Ser Ile Tyr 
        835                 840                 845             


His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr Lys 
    850                 855                 860                 


Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His Gly 
865                 870                 875                 880 


Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr Asn 
                885                 890                 895     


Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg Asn 
            900                 905                 910         


Glu Tyr Leu Thr Glu Lys 
        915             


<210>  3244
<211>  918
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3244

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Gly Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Asn Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Glu 
    370                 375                 380                 


Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Ile Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Leu Tyr Ala Asp Glu Ala Ala Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Lys Val Ala Glu Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu Arg 
785                 790                 795                 800 


Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr Arg 
                805                 810                 815     


Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu Lys 
            820                 825                 830         


Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile Tyr 
        835                 840                 845             


His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr Lys 
    850                 855                 860                 


Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His Gly 
865                 870                 875                 880 


Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr Asn 
                885                 890                 895     


Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg Asn 
            900                 905                 910         


Glu Tyr Leu Thr Glu Lys 
        915             


<210>  3245
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3245

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Lys Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asp Asn Asp Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser 
        195                 200                 205             


His Asp Asp Phe Ile Gly Tyr Leu Ser Thr Asn Asn Ile Tyr Asp Val 
    210                 215                 220                 


Phe Ile Asp Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn 
225                 230                 235                 240 


Val Arg Lys Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala 
            260                 265                 270         


Ser Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Asp Phe 
                325                 330                 335     


Ile Glu Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3246
<211>  1011
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3246

Met Val Val Thr Tyr Leu Lys Trp Ile Ile Ile Leu Arg Glu Gly Thr 
1               5                   10                  15      


Met Lys Met Ala Lys Lys Lys Asn Ala Lys Gln Arg Arg Glu Glu Glu 
            20                  25                  30          


Lys Asn Arg Leu Lys Ala Lys Ile Glu Lys Phe Lys Ile Lys Tyr Ala 
        35                  40                  45              


Glu Gln Glu Thr Val Asp Lys Ile Thr Glu Glu Ile Ala Gln Ser Asp 
    50                  55                  60                  


Lys Ile Met Arg Thr Glu Ser Ile Leu Val Gln His Thr Lys Lys Ser 
65                  70                  75                  80  


Leu Ala Lys Ala Ser Gly Val Lys Ser Val Phe Ile Lys Asp Asp Glu 
                85                  90                  95      


Val Ile Met Thr Ser Phe Gly Arg Gly Asn Asp Ala Val Val Glu Lys 
            100                 105                 110         


Ile Ile Lys Asp Asn Asn Val Asp Glu Lys Asn Thr Lys Pro Ala Tyr 
        115                 120                 125             


Glu Ile Val Asp Ile Glu Lys Asn Gly Asp Leu Ile Lys Val Gln Ser 
    130                 135                 140                 


Arg Arg Cys Lys Asn Ile Glu Ser Ala Asn Thr Glu Leu Pro Pro Glu 
145                 150                 155                 160 


Lys Ile Gly Met Asp Leu Ile Arg Cys Lys Asp Lys Leu Glu Glu Ile 
                165                 170                 175     


Tyr Phe Gly Arg Thr Phe Asn Asp Asn Ile His Ile Gln Leu Ile Tyr 
            180                 185                 190         


Asn Ile Leu Asp Ile Glu Lys Ile Leu Ser Val Tyr Ile Asn Asn Ala 
        195                 200                 205             


Val Tyr Ala Leu Gly Asn Leu Glu Arg Lys Glu Asn Asp Lys Glu Lys 
    210                 215                 220                 


Asp Leu Val Gly Tyr Leu Ser Ala Arg Ala Gly Tyr Asn Lys Val Ile 
225                 230                 235                 240 


Asn Lys Ala Ile Asn Asp Glu Lys Ile Lys Asp Arg Ile Glu Asp Leu 
                245                 250                 255     


Lys Glu Phe Ile Glu Asn Gly Asn Arg Leu Gly Tyr Phe Gly Asp Ile 
            260                 265                 270         


Phe Phe Lys Lys Glu Glu Val Ser Lys Asn Gly Lys Lys Pro Lys Lys 
        275                 280                 285             


Val Glu Val Leu Lys Ser Glu Lys Glu Ile Phe Asp Ile Leu Ala Leu 
    290                 295                 300                 


Leu Gly Ser Leu Arg Gln Phe Cys Phe His Tyr Asp Glu Ala Val Phe 
305                 310                 315                 320 


Glu Asn Glu Asp Gly Val Ile Asp Lys Glu Tyr Asn Asp Asn Ser Trp 
                325                 330                 335     


Leu Tyr Asn Leu Glu Lys Leu Glu Pro Glu Phe Lys Asp Thr Leu Asp 
            340                 345                 350         


Tyr Phe Tyr Asn Arg Lys Ile Asn Asp Ile Asn Lys Gly Phe Ile Lys 
        355                 360                 365             


Thr Asn Gln Ile Asn Leu His Ile Ile Cys Asp Glu Leu Gly Leu Asn 
    370                 375                 380                 


Trp Asp Lys Glu Gln Val Val Gly Asp Tyr Tyr Asp Phe Leu Ile Ala 
385                 390                 395                 400 


Lys Lys Tyr Lys Asn Ile Gly Phe Ser Ile Lys Lys Ile Arg Glu His 
                405                 410                 415     


Met Phe Asp Ile Tyr Glu Ala Phe Asp Ile Lys Asp Lys Arg Phe Asp 
            420                 425                 430         


Ser Val Arg Ser Ile Met Tyr Lys Ile Ile Asp Phe Val Ile Tyr Tyr 
        435                 440                 445             


Ser Phe Ile His Tyr Lys Gln Asp Glu Val Asp Glu Ile Val Asn Tyr 
    450                 455                 460                 


Leu Arg Ser Thr Leu Ser Glu Glu Gln Lys Lys Glu Lys Tyr Ile Lys 
465                 470                 475                 480 


Leu Ala Gly Asn Ile Trp Ala Glu Tyr Lys Thr Gln Phe Asn Lys Leu 
                485                 490                 495     


Lys Asp Ile Leu Leu Ala Asn Ile Lys Glu Phe Ser Asp Ala Lys Glu 
            500                 505                 510         


Asp Asp Val Tyr Tyr Glu Glu Phe Lys Asn Phe Lys Phe Asn Glu Val 
        515                 520                 525             


Gly Lys Glu Lys Leu Gly Glu Asn Ala Glu Tyr Phe Cys Lys Leu Met 
    530                 535                 540                 


Tyr Leu Leu Thr Leu Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu 
545                 550                 555                 560 


Thr Thr Leu Ile Asn Lys Phe Asp Asn Ile Arg Ser Phe Val Glu Leu 
                565                 570                 575     


Met Lys Glu Glu Asn Ile Glu Cys Ile Phe Asp Lys Lys Phe Ala Phe 
            580                 585                 590         


Phe Asp Glu Ser Lys Asn Val Cys Ser Thr Leu Arg Glu Ile Asn Ser 
        595                 600                 605             


Phe Ala Arg Met Gln Lys Pro Leu Asn Asn Val Ser Val Lys Arg Glu 
    610                 615                 620                 


Met Tyr Lys Asp Ala Ile Lys Ile Leu Leu Lys Asp Thr Arg Ala Glu 
625                 630                 635                 640 


Glu Gln Asn Ile Asp Arg Ile Leu Asn Glu Tyr Ile Pro Ser Lys Glu 
                645                 650                 655     


Asp Lys Gly Ile Lys Lys Asp Phe Arg Asn Phe Ile Ile Lys Asn Ile 
            660                 665                 670         


Ile Lys Ser Asn Arg Phe Met Tyr Leu Val Lys Tyr Ser Asn Pro Thr 
        675                 680                 685             


Asp Val Arg Asn Leu Ala Ser Asn Arg Asn Val Val Lys Phe Val Leu 
    690                 695                 700                 


Asn Ala Ile Pro Asp Thr Gln Ile Asp Arg Tyr Tyr Lys Ser Cys Ile 
705                 710                 715                 720 


Gln His Tyr Ser Asn Glu Val Asp Lys Glu Thr Gln Ile Gln Glu Leu 
                725                 730                 735     


Thr Asp Ile Ile Thr Gly Ile Asp Tyr Leu Asp Phe Leu Asp Val Arg 
            740                 745                 750         


Gln Ser Tyr Arg Asn Glu Asp Lys Ser Lys Lys Gln Ala Val Val Thr 
        755                 760                 765             


Leu Tyr Leu Thr Ile Leu Tyr Ile Leu Thr Lys Asn Leu Val Asn Val 
    770                 775                 780                 


Asn Ser Arg Tyr Val Ile Ala Leu His Cys Leu Glu Arg Asp Ser Lys 
785                 790                 795                 800 


Leu Tyr Gly Tyr Thr Lys Leu Ser Lys Lys Asn Asn Lys Lys Leu Glu 
                805                 810                 815     


Lys Ile Lys Pro Pro Lys Tyr His Glu Leu Thr Lys Tyr Phe Ile Asp 
            820                 825                 830         


Asn Arg Tyr Phe Asp Arg Lys Lys Lys Asn Lys Lys Tyr Gly Glu Tyr 
        835                 840                 845             


Thr Ser Lys Lys Ile Ser Thr Tyr Ile Glu Thr Asn Met Lys Asn Phe 
    850                 855                 860                 


Ile Gly Cys Glu Gln Phe Arg Thr Pro Glu Arg Tyr Arg Asp Thr Gln 
865                 870                 875                 880 


Ile Asp Met Phe Val Lys Tyr Arg Asn Ser Ile Ala His Leu Asn Ala 
                885                 890                 895     


Val Arg Lys Ala Ser Lys Tyr Ile Asn Asp Ile Arg Gly Phe Asp Thr 
            900                 905                 910         


Tyr Phe Glu Leu Tyr His Tyr Ile Met Gln Arg Asp Leu Lys Asp Ile 
        915                 920                 925             


Leu Glu Lys Ile Ala Glu Gly Ala Ala Lys Glu Thr Glu Glu Gly Gln 
    930                 935                 940                 


Lys Gln Asp Glu Leu Leu Lys Thr Tyr Phe Asp Asn Leu Asp Lys Tyr 
945                 950                 955                 960 


Gly Thr Tyr Val Lys Asp Phe Val Lys Ala Leu Asn Ile Pro Phe Ala 
                965                 970                 975     


Tyr Asn Tyr Pro Arg Tyr Lys Asn Leu Ser Ile Asp Glu Leu Phe Asp 
            980                 985                 990         


Lys Asn Asn Thr Arg Lys Thr Ile  Lys Ile Gln Asp Lys  Lys Leu Glu 
        995                 1000                 1005             


Glu Arg  Thr 
    1010     


<210>  3247
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3247

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Ile Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Pro Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn His Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr His Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3248
<211>  923
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3248

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asp Asn Asp Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asn 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Ser Val Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Gln Asn Thr Tyr Tyr Ile 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val 
            260                 265                 270         


Ser Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu 
    290                 295                 300                 


Tyr Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Asp Asp Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile 
        355                 360                 365             


Val Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg 
    370                 375                 380                 


Glu Lys Met Leu Glu Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Ser Lys Met Tyr Lys Ile Met Asp Phe Leu Leu Phe 
                405                 410                 415     


Cys Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg 
            420                 425                 430         


Lys Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala 
        435                 440                 445             


Asp Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn 
    450                 455                 460                 


Ile Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala 
465                 470                 475                 480 


Asp Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala 
                485                 490                 495     


Ser Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe 
            500                 505                 510         


Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys 
        515                 520                 525             


Phe Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val 
    530                 535                 540                 


Asp Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser 
545                 550                 555                 560 


Gln Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met 
                565                 570                 575     


Arg Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu 
            580                 585                 590         


Ala Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu 
        595                 600                 605             


Ile Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn 
    610                 615                 620                 


Phe Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile 
625                 630                 635                 640 


Lys Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys 
                645                 650                 655     


Val Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg 
            660                 665                 670         


Tyr Tyr Lys Ser Cys Val Glu Val Pro Asp Met Asn Ser Ser Leu Glu 
        675                 680                 685             


Ala Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp 
    690                 695                 700                 


Asp Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala 
705                 710                 715                 720 


Lys Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr 
                725                 730                 735     


Leu Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala 
            740                 745                 750         


Ile His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro 
        755                 760                 765             


Glu Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln 
    770                 775                 780                 


Thr Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys 
785                 790                 795                 800 


Asn Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp 
                805                 810                 815     


Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val 
            820                 825                 830         


Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser 
        835                 840                 845             


Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg 
    850                 855                 860                 


Glu Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu 
865                 870                 875                 880 


Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser 
                885                 890                 895     


Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln 
            900                 905                 910         


Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920             


<210>  3249
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3249

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asp Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asn Glu Ser Ser Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Gly 
    850                 855                 860                 


Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3250
<211>  917
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3250

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Lys Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asp Tyr Asn 
                85                  90                  95      


Gln Thr Gln Leu Ser Ser Glu Asp Ser Ser Asn Ile Glu Leu Arg Gly 
            100                 105                 110         


Val Thr Lys Val Asn Ile Thr Phe Ser Ser Lys His Gly Leu Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser 
        195                 200                 205             


His Asp Asp Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val 
    210                 215                 220                 


Phe Ile Asp Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn 
225                 230                 235                 240 


Val Arg Lys Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Lys Glu Pro Lys Thr Lys Asp Asn Arg Val 
            260                 265                 270         


Ser Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Cys Val Phe His Asp Leu Ser Glu His Leu Glu Tyr 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Asn Ser Lys Lys Val Tyr Arg Glu Cys 
305                 310                 315                 320 


Arg Glu Thr Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn 
                325                 330                 335     


Lys Gly Phe Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp 
            340                 345                 350         


Met Met Lys Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp 
        355                 360                 365             


Phe Ile Val Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Lys Met Leu His Val Tyr Gly Phe Arg Phe Lys Asp Lys 
385                 390                 395                 400 


Gln Tyr Asp Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu 
                405                 410                 415     


Leu Phe Cys Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu 
            420                 425                 430         


Val Arg Lys Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile 
        435                 440                 445             


Tyr Ala Asp Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe 
    450                 455                 460                 


Glu Asn Ile Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly 
465                 470                 475                 480 


Lys Ala Asp Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys 
                485                 490                 495     


Asn Ala Ser Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr 
            500                 505                 510         


Tyr Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile 
        515                 520                 525             


Ser Lys Phe Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser 
    530                 535                 540                 


Ala Val Asp Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn 
545                 550                 555                 560 


Asp Ser Gln Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala 
                565                 570                 575     


Ser Met Arg Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp 
            580                 585                 590         


Ala Leu Thr Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile 
        595                 600                 605             


Ser Glu Ile Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu 
    610                 615                 620                 


Arg Asn Phe Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr 
625                 630                 635                 640 


Leu Ile Lys Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn 
                645                 650                 655     


Glu Lys Val Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile 
            660                 665                 670         


Glu Arg Tyr Tyr Lys Ser Cys Val Glu Val Thr Asp Met Asn Ser Ser 
        675                 680                 685             


Leu Glu Ala Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg 
    690                 695                 700                 


Phe Asp Asp Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn 
705                 710                 715                 720 


Val Ala Lys Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val 
                725                 730                 735     


Met Tyr Leu Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val 
            740                 745                 750         


Ile Ala Ile His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile 
        755                 760                 765             


Ile Pro Glu Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu 
    770                 775                 780                 


Ser Gln Thr Leu Cys Glu Leu Cys Asp Asp Arg Asp Lys Ser Pro Asn 
785                 790                 795                 800 


Leu Phe Leu Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp 
                805                 810                 815     


Ile Asn Asn Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile 
            820                 825                 830         


Ala His Leu Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile 
        835                 840                 845             


Arg Thr Val Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg 
    850                 855                 860                 


Cys Ile Thr Lys Arg Glu Asn Asp Thr Lys Gln Glu Asp His Gly Tyr 
865                 870                 875                 880 


Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr Asn Ile 
                885                 890                 895     


Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg Asn Glu 
            900                 905                 910         


Tyr Leu Thr Glu Lys 
        915         


<210>  3251
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3251

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Val Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Met Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Glu Ser Ser Ser Asn Ile Lys Leu Cys Gly 
            100                 105                 110         


Val Thr Lys Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser 
        195                 200                 205             


His Asp Asp Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val 
    210                 215                 220                 


Phe Ile Asp Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn 
225                 230                 235                 240 


Val Arg Lys Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Asn Arg Val 
            260                 265                 270         


Ser Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asn Asn Ile Tyr Pro Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Gly 
        435                 440                 445             


Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Val Pro Asp Met Asn Ser Ser Leu Glu Ala 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Asp Arg Asp Lys Ser Pro Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  3252
<211>  921
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3252

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Val Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Leu Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr Tyr Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Leu Ser Glu His Ser Glu Tyr Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asp Asn Ser Lys Lys Val Tyr Arg Glu Cys Arg Glu Thr Leu 
305                 310                 315                 320 


Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile 
                325                 330                 335     


Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly 
            340                 345                 350         


Tyr Glu Pro Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu 
        355                 360                 365             


Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys 
    370                 375                 380                 


Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser 
385                 390                 395                 400 


Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn 
                405                 410                 415     


Tyr Tyr Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu 
            420                 425                 430         


Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu 
        435                 440                 445             


Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala 
    450                 455                 460                 


Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met 
465                 470                 475                 480 


Asn Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp 
                485                 490                 495     


Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp 
            500                 505                 510         


Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp 
        515                 520                 525             


Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val 
    530                 535                 540                 


Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg 
545                 550                 555                 560 


Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys 
                565                 570                 575     


Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile 
            580                 585                 590         


Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu 
        595                 600                 605             


Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile 
    610                 615                 620                 


Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr 
625                 630                 635                 640 


Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val 
                645                 650                 655     


Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr 
            660                 665                 670         


Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys 
        675                 680                 685             


Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe 
    690                 695                 700                 


Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu 
705                 710                 715                 720 


Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu 
                725                 730                 735     


Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His 
            740                 745                 750         


Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu 
        755                 760                 765             


Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu 
    770                 775                 780                 


Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu 
785                 790                 795                 800 


Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser 
                805                 810                 815     


Met Thr Arg Lys Tyr Arg Asn Arg Ile Ala His Leu Thr Val Val Arg 
            820                 825                 830         


Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe 
        835                 840                 845             


Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp 
    850                 855                 860                 


Asp Thr Lys Gln Gly Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys 
865                 870                 875                 880 


Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe 
                885                 890                 895     


Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe 
            900                 905                 910         


Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920     


<210>  3253
<211>  927
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3253

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Thr Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asp Tyr Asn 
                85                  90                  95      


Gln Thr Gln Leu Ser Ser Lys Asp Ser Ser Asn Ile Glu Leu His Gly 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Leu Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Ser Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Asp Ser Asn 
        195                 200                 205             


Tyr Asp Phe Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe 
    210                 215                 220                 


Thr Asn Pro Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Lys Asn Ile 
225                 230                 235                 240 


Arg Lys Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu 
                245                 250                 255     


Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Asn Ala Leu 
            260                 265                 270         


Glu Ala Tyr Lys Lys Arg Val Tyr Tyr Met Leu Ala Ile Val Gly Gln 
        275                 280                 285             


Ile Arg Gln Cys Val Phe His Asp Leu Thr Asp His Ser Glu Tyr Asp 
    290                 295                 300                 


Leu Tyr Ser Phe Ile Tyr Asn Ser Lys Lys Val Tyr Lys Glu Cys Arg 
305                 310                 315                 320 


Glu Thr Leu Asp Tyr Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys 
                325                 330                 335     


Gly Phe Ile Glu Gly Asn Lys Ile Asn Ile Ser Leu Leu Ile Asp Met 
            340                 345                 350         


Met Lys Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe 
        355                 360                 365             


Ile Val Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu 
    370                 375                 380                 


Arg Glu Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln 
385                 390                 395                 400 


Tyr Asp Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu 
                405                 410                 415     


Phe Cys Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val 
            420                 425                 430         


Arg Lys Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr 
        435                 440                 445             


Ala Asp Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu 
    450                 455                 460                 


Asn Ile Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys 
465                 470                 475                 480 


Ala Asp Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn 
                485                 490                 495     


Ala Ser Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr 
            500                 505                 510         


Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser 
        515                 520                 525             


Lys Phe Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala 
    530                 535                 540                 


Val Asp Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp 
545                 550                 555                 560 


Ser Gln Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser 
                565                 570                 575     


Met Arg Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala 
            580                 585                 590         


Leu Thr Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser 
        595                 600                 605             


Glu Ile Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg 
    610                 615                 620                 


Asn Phe Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu 
625                 630                 635                 640 


Ile Lys Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu 
                645                 650                 655     


Lys Val Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu 
            660                 665                 670         


Arg Tyr Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu 
        675                 680                 685             


Glu Ala Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe 
    690                 695                 700                 


Asp Asp Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val 
705                 710                 715                 720 


Ala Lys Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met 
                725                 730                 735     


Tyr Leu Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile 
            740                 745                 750         


Ala Ile His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile 
        755                 760                 765             


Pro Glu Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser 
    770                 775                 780                 


Gln Thr Leu Cys Glu Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu 
785                 790                 795                 800 


Phe Leu Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile 
                805                 810                 815     


Asn Asn Ala Asp Ser Ile Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala 
            820                 825                 830         


His Leu Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg 
        835                 840                 845             


Thr Val Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys 
    850                 855                 860                 


Ile Thr Lys Arg Glu Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr 
865                 870                 875                 880 


Glu Asp Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys 
                885                 890                 895     


Ala Leu Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu 
            900                 905                 910         


Ser Ile Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925         


<210>  3254
<211>  957
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3254

Met Ile Leu Ile Leu Gly Glu Gly Thr Ile Arg Met Ala Lys Lys Lys 
1               5                   10                  15      


Asn Ala Arg Gln Arg Arg Glu Glu Glu Lys Asn Arg Ile Lys Ala Ile 
            20                  25                  30          


Ile Glu Lys Ile Lys Asn Lys Val Val Glu Lys Glu Glu Thr Glu Glu 
        35                  40                  45              


Ile Val Glu Asn Asn Glu Thr Lys Asn Val Glu Ser Ile Val Val Glu 
    50                  55                  60                  


Pro Lys Lys Lys Ser Leu Ala Lys Ala Ser Gly Val Lys Ser Val Phe 
65                  70                  75                  80  


Ile Asn Asn Asp Glu Ile Ile Met Thr Ser Phe Gly Arg Gly Asn Asp 
                85                  90                  95      


Ala Val Ile Glu Lys Ile Ile Lys Asp Asn Asn Ile Asp Asn Glu Asn 
            100                 105                 110         


Lys Asp Lys Pro Val Tyr Asp Val Val Ala Ile Glu Asn Glu Gly Asn 
        115                 120                 125             


Ile Ile Lys Val Gln Ser Glu Arg Phe Lys Ala Ile Glu Ser Ala Asn 
    130                 135                 140                 


Thr Glu Ile Pro Pro Glu Arg Asn Gly Met Asp Leu Ile Lys Arg Lys 
145                 150                 155                 160 


Asp Lys Leu Glu Glu Val Tyr Phe Gly His Thr Phe Asn Asp Asn Ile 
                165                 170                 175     


His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ser 
            180                 185                 190         


Val Tyr Ile Asn Asn Ile Val Tyr Ala Leu Gly Asn Leu Glu Arg Lys 
        195                 200                 205             


Asp Thr Asp Glu Glu Lys Asp Leu Ile Gly Tyr Ser Ser Ala Arg Ala 
    210                 215                 220                 


Lys Tyr Glu Asp Phe Ile Glu Asn Glu Lys Leu Glu Asp Arg Lys Lys 
225                 230                 235                 240 


Leu Leu Glu Glu Phe Ile Glu Asn Gly Asp Arg Leu Gly Tyr Phe Gly 
                245                 250                 255     


Asn Val Phe Phe Lys Asn Asp Lys Glu Leu Lys Ser Lys Lys Glu Ile 
            260                 265                 270         


Tyr Asn Ile Leu Gly Leu Leu Gly Ser Leu Arg Gln Phe Cys Phe His 
        275                 280                 285             


Tyr Asn Glu Ala Val Phe Glu Asn Glu Glu Gly Lys Ile Asn Gln Glu 
    290                 295                 300                 


Tyr Lys Ser Asn Ser Trp Leu Tyr Asn Leu Gly Gln Leu Phe Asp Glu 
305                 310                 315                 320 


Phe Lys Asp Thr Leu Asn Gly Phe Tyr Asn Glu Lys Ile Asp Ser Ile 
                325                 330                 335     


Asn Lys Asp Phe Ile Lys Thr Asn Gln Ile Asn Leu His Ile Ile Cys 
            340                 345                 350         


Ser Glu Leu Gly Met Asn Met Asp Lys Glu Gln Val Val Gly Asp Tyr 
        355                 360                 365             


Tyr Asp Phe Ile Ile Ser Lys Lys His Lys Asn Met Gly Phe Ser Ile 
    370                 375                 380                 


Lys Lys Ile Arg Glu Tyr Met Phe Asp Ile Tyr Glu Ala Phe Asp Ile 
385                 390                 395                 400 


Lys Asp Lys Glu Phe Asp Ser Val Arg Ser Ile Leu Tyr Lys Ile Ile 
                405                 410                 415     


Asp Phe Ile Ile Tyr Tyr Ser Phe Ile His Tyr Lys Asn Asp Ile Ala 
            420                 425                 430         


Glu Asn Ile Val Ser Arg Leu Arg Val Ser Leu Ser Glu Glu Asp Lys 
        435                 440                 445             


Asp Lys Val Tyr Glu Glu Ile Ala Arg Asp Thr Trp Asn Glu Tyr Lys 
    450                 455                 460                 


Asp Gln Ile Asn Lys Leu Lys Glu Leu Leu Thr Lys Arg Ile Gly Glu 
465                 470                 475                 480 


Phe Ser Asp Ala Lys Asn Lys Asn Val Tyr Tyr Lys Glu Phe Glu Ser 
                485                 490                 495     


Ile Lys Phe Asp Glu Ile Gly Lys Lys Lys Leu Gly Glu Asn Ala Asp 
            500                 505                 510         


Tyr Phe Cys Lys Leu Met Tyr Leu Leu Thr Leu Phe Leu Asp Gly Lys 
        515                 520                 525             


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp Asn Ile 
    530                 535                 540                 


Arg Ser Phe Ile Glu Ile Met Glu Glu Lys Gln Ile Glu Cys Asn Phe 
545                 550                 555                 560 


Asp Glu Lys Phe Ser Phe Phe Asp Glu Ser Lys Asn Val Cys Asp Thr 
                565                 570                 575     


Leu Arg Glu Val Asn Ser Phe Ala Arg Met Gln Arg Pro Leu Asp Asn 
            580                 585                 590         


Lys Ser Val Gln Arg Glu Met Tyr Arg Asp Ala Ile Lys Ile Leu Leu 
        595                 600                 605             


Lys Asp Thr Trp Val Glu Glu Lys Asn Ile Asp Arg Ile Leu Asp Glu 
    610                 615                 620                 


Tyr Ile Pro Asn Lys Glu Asn Lys Ser Ile Lys Lys Asp Phe Arg Asn 
625                 630                 635                 640 


Phe Ile Ile Lys Asn Ile Ile Lys Ser Asn Arg Phe Ile Tyr Leu Ile 
                645                 650                 655     


Lys Tyr Ser Asn Pro Thr Asp Val Arg Lys Leu Ala Ser Asn Lys Asp 
            660                 665                 670         


Val Val Lys Phe Val Leu Asn Thr Ile Pro Glu Ala Gln Ile Asp Arg 
        675                 680                 685             


Tyr Tyr Asn Ser Cys Gly Leu Pro Leu Glu Glu Asp Asn Asn Val Gln 
    690                 695                 700                 


Ile Glu Lys Leu Ser Glu Ile Ile Thr Asn Ile Asp Tyr Ile Glu Phe 
705                 710                 715                 720 


Leu Asp Val Gln Gln Ser Tyr Lys Asn Glu Asp Lys Ser Gln Lys Gln 
                725                 730                 735     


Ala Val Val Thr Leu Tyr Leu Thr Ile Leu Tyr Ile Leu Thr Lys Asn 
            740                 745                 750         


Leu Val Asn Val Asn Ser Arg Tyr Val Ile Ala Leu His Cys Leu Glu 
        755                 760                 765             


Arg Asp Ser Thr Leu Tyr Gly Ile Lys Leu Lys Lys Glu Lys Asn Lys 
    770                 775                 780                 


Pro Ser Lys Tyr His Lys Leu Thr Gln Tyr Phe Ile Asp Asn Arg Tyr 
785                 790                 795                 800 


Phe Asp Arg Lys Lys Lys Asp Arg Lys Asn Gly Glu Tyr Val Ser Lys 
                805                 810                 815     


Lys Ile Ser Gly Tyr Ile Glu Lys Asn Met Lys Asn Tyr Ile Glu Cys 
            820                 825                 830         


Glu Gln Ile Glu Thr Thr Glu Gln Tyr Lys Glu Thr Gly Val Asp Met 
        835                 840                 845             


Phe Ile Asn Tyr Arg Asn Ser Ile Ala His Leu Asn Thr Val Arg Lys 
    850                 855                 860                 


Ala Ser Lys Tyr Ile Lys Asp Ile Lys Tyr Phe Gly Thr Tyr Phe Glu 
865                 870                 875                 880 


Leu Tyr His Tyr Ile Met Gln Arg Tyr Leu Lys Asp Asn Ile Glu Leu 
                885                 890                 895     


Lys Gly Glu Asn Asn Ala Leu Glu Gly Tyr Phe Asp Asn Leu Cys Lys 
            900                 905                 910         


Tyr Gly Thr Tyr Val Lys Asp Phe Val Lys Thr Leu Asn Val Pro Phe 
        915                 920                 925             


Ala Tyr Asn Tyr Pro Arg Tyr Lys Asn Leu Ser Ile Asp Glu Leu Phe 
    930                 935                 940                 


Asp Lys Asn Asn Thr Arg Lys Thr Lys Lys Ser Ser Leu 
945                 950                 955         


<210>  3255
<211>  939
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3255

Met Ala Lys Lys Lys Arg Ile Thr Ala Lys Glu Arg Lys Gln Asn His 
1               5                   10                  15      


Arg Glu Leu Leu Met Lys Lys Ala Asp Ser Asn Ala Glu Lys Glu Lys 
            20                  25                  30          


Ala Lys Lys Pro Val Val Glu Asn Lys Pro Asp Thr Ala Ile Ser Lys 
        35                  40                  45              


Asp Asn Thr Pro Lys Pro Asn Lys Glu Ile Lys Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Ala Gly Val Lys Trp Val Ile Lys Ala Asn Asp Asp Val Ala Tyr 
65                  70                  75                  80  


Ile Ser Ser Phe Gly Lys Gly Asn Asn Ser Val Leu Glu Lys Arg Ile 
                85                  90                  95      


Met Gly Asp Val Ser Ser Asn Val Asn Lys Asp Ser His Met Tyr Val 
            100                 105                 110         


Asn Pro Lys Tyr Thr Lys Lys Asn Tyr Glu Ile Lys Asn Gly Phe Ser 
        115                 120                 125             


Ser Gly Ser Ser Leu Val Thr Tyr Pro Asn Lys Pro Asp Lys Asn Ser 
    130                 135                 140                 


Gly Met Asp Ala Leu Cys Leu Lys Pro Tyr Phe Glu Lys Asp Phe Phe 
145                 150                 155                 160 


Gly His Ile Phe Thr Asp Asn Met His Ile Gln Ala Ile Tyr Asn Ile 
                165                 170                 175     


Phe Asp Ile Glu Lys Ile Leu Ala Lys His Ile Thr Asn Ile Ile Tyr 
            180                 185                 190         


Thr Val Asn Ser Phe Asp Arg Asn Tyr Asn Gln Ser Gly Asn Asp Thr 
        195                 200                 205             


Ile Gly Phe Gly Leu Asn Tyr Arg Val Pro Tyr Ser Glu Tyr Gly Gly 
    210                 215                 220                 


Gly Lys Asp Ser Asn Gly Glu Pro Lys Asn Lys Phe Lys Trp Glu Lys 
225                 230                 235                 240 


Arg Asp Asn Phe Ser Lys Phe Tyr Asn Glu Ser Lys Pro His Leu Gly 
                245                 250                 255     


Tyr Tyr Glu Asn Ile Phe Tyr Asp His Gly Glu Pro Ile Ser Glu Glu 
            260                 265                 270         


Lys Phe Tyr Asn Tyr Leu Asn Ile Leu Asn Phe Ile Arg Asn Asn Thr 
        275                 280                 285             


Phe His Tyr Lys Asp Asn Asp Ile Glu Leu Tyr Ser Glu Asn Tyr Ser 
    290                 295                 300                 


Glu Glu Tyr Val Phe Ile Asn Cys Leu Asn Lys Phe Val Lys Asn Lys 
305                 310                 315                 320 


Phe Lys Asn Val Asn Lys Asn Phe Ile Ser Asn Glu Lys Asn Asn Leu 
                325                 330                 335     


Tyr Ile Ile Leu Asn Ala Tyr Gly Lys Asp Thr Glu Asn Val Glu Val 
            340                 345                 350         


Val Lys Lys Tyr Ser Lys Glu Leu Tyr Lys Leu Ser Val Leu Lys Thr 
        355                 360                 365             


Asn Lys Asn Leu Gly Val Asn Val Lys Lys Leu Arg Glu Ser Ala Ile 
    370                 375                 380                 


Glu Tyr Gly Tyr Cys Pro Leu Pro Tyr Asp Lys Glu Lys Glu Val Ala 
385                 390                 395                 400 


Lys Leu Ser Ser Val Lys His Lys Leu Tyr Lys Thr Tyr Asp Phe Val 
                405                 410                 415     


Ile Thr His Tyr Leu Asn Ser Asn Asp Lys Ile Leu Leu Glu Ile Val 
            420                 425                 430         


Glu Ala Leu Arg Leu Ser Lys Asn Asp Asp Glu Lys Glu Asn Val Tyr 
        435                 440                 445             


Lys Lys Tyr Ala Glu Lys Leu Phe Lys Ala Asp Asp Val Ile Asn Pro 
    450                 455                 460                 


Ile Lys Ala Ile Ser Lys Leu Phe Val Glu Lys Gly Asn Lys Leu Phe 
465                 470                 475                 480 


Lys Glu Lys Ile Ile Ile Lys Lys Glu Tyr Ile Glu Asp Val Ser Ile 
                485                 490                 495     


Asp Lys Asn Ile Tyr Asp Phe Thr Lys Val Ile Phe Phe Met Thr Cys 
            500                 505                 510         


Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Asn Ile Ile Ser 
        515                 520                 525             


Lys Leu Gln Ile Ile Glu Asp His Asn Asn Val Ile Lys Phe Ile Ser 
    530                 535                 540                 


His Asn Lys Asp Ala Val Tyr Lys Asp Tyr Ser Asp Lys Tyr Ala Ile 
545                 550                 555                 560 


Phe Arg Asn Ala Gly Lys Ile Ala Thr Glu Leu Glu Ala Ile Lys Ser 
                565                 570                 575     


Ile Ala Arg Met Glu Asn Lys Ile Glu Asn Ala Ser Gln Glu Pro Leu 
            580                 585                 590         


Leu Asn Asp Ala Leu Leu Ser Leu Gly Val Ser Asp Asp Thr Lys Val 
        595                 600                 605             


Leu Glu Asn Thr Tyr Lys Lys Tyr Phe Asp Ser Lys Glu Lys Thr Asp 
    610                 615                 620                 


Lys Gln Ser Gln Lys Val Ser Thr Phe Leu Met Asn Asn Val Ile Asn 
625                 630                 635                 640 


Asn Asn Arg Phe Lys Tyr Val Ile Lys Tyr Ile Asn Pro Ala Asp Ile 
                645                 650                 655     


Asn Gly Leu Ala Lys Asn Arg Tyr Leu Val Lys Phe Val Leu Ser Lys 
            660                 665                 670         


Ile Pro Glu Glu Gln Ile Asp Ser Tyr Tyr Lys Leu Phe Ser Asn Glu 
        675                 680                 685             


Glu Glu Pro Gly Cys Glu Glu Lys Ile Lys Leu Leu Thr Lys Lys Ile 
    690                 695                 700                 


Ser Lys Leu Asn Phe Gln Thr Leu Phe Glu Asn Asn Lys Ile Pro Asn 
705                 710                 715                 720 


Val Glu Lys Glu Lys Lys Lys Ala Ile Ile Thr Leu Tyr Phe Thr Ile 
                725                 730                 735     


Val Tyr Ile Leu Val Lys Asn Leu Val Asn Ile Asn Gly Leu Tyr Thr 
            740                 745                 750         


Leu Ala Leu Tyr Phe Val Glu Arg Asp Gly Tyr Phe Tyr Lys Asp Ile 
        755                 760                 765             


Cys Gly Lys Lys Asp Lys Lys Lys Ser Tyr Asn Asp Val Asp Tyr Leu 
    770                 775                 780                 


Leu Leu Pro Glu Ile Phe Ser Gly Ser Lys Tyr Arg Glu Glu Thr Lys 
785                 790                 795                 800 


Asn Leu Lys Leu Pro Lys Glu Lys Asp Arg Asp Ile Met Lys Lys Tyr 
                805                 810                 815     


Leu Pro Asn Asp Lys Asp Arg Glu Lys Tyr Asn Lys Phe Phe Thr Ala 
            820                 825                 830         


Tyr Arg Asn Asn Ile Val His Leu Asn Ile Ile Ala Lys Leu Ser Glu 
        835                 840                 845             


Leu Thr Lys Asn Ile Asp Lys Asp Ile Asn Ser Tyr Phe Asp Ile Tyr 
    850                 855                 860                 


His Tyr Cys Thr Gln Arg Val Met Phe Asn Tyr Cys Lys Glu Lys Asn 
865                 870                 875                 880 


Asp Val Val Leu Ala Lys Met Lys Asp Leu Ala His Ile Lys Ser Asp 
                885                 890                 895     


Cys Asn Glu Phe Ser Ser Lys His Thr Tyr Pro Phe Ser Ser Ala Val 
            900                 905                 910         


Leu Arg Phe Met Asn Leu Pro Phe Ala Tyr Asn Val Pro Arg Phe Lys 
        915                 920                 925             


Asn Leu Ser Tyr Lys Lys Phe Phe Asp Lys Gln 
    930                 935                 


<210>  3256
<211>  939
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3256

Met Ala Lys Lys Lys Arg Ile Thr Ala Lys Glu Arg Lys Gln Asn His 
1               5                   10                  15      


Arg Glu Leu Leu Met Lys Lys Ala Asp Ser Asn Ala Glu Lys Glu Lys 
            20                  25                  30          


Ala Lys Lys Pro Val Val Glu Asn Lys Pro Asp Thr Ala Ile Ser Lys 
        35                  40                  45              


Asp Asn Thr Pro Lys Pro Asn Lys Glu Ile Lys Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Ala Gly Val Lys Trp Val Ile Lys Ala Asn Asp Asp Val Ala Tyr 
65                  70                  75                  80  


Ile Ser Ser Phe Gly Lys Gly Asn Asn Ser Val Leu Glu Lys Arg Ile 
                85                  90                  95      


Met Gly Asp Val Ser Ser Asn Val Asn Lys Asp Ser His Met Tyr Val 
            100                 105                 110         


Asn Pro Lys Tyr Thr Lys Lys Asn Tyr Glu Ile Lys Asn Gly Phe Ser 
        115                 120                 125             


Ser Gly Ser Ser Leu Val Thr Tyr Pro Asn Lys Pro Asp Lys Asn Ser 
    130                 135                 140                 


Gly Met Asp Ala Leu Cys Leu Lys Pro Tyr Phe Glu Lys Asp Phe Phe 
145                 150                 155                 160 


Gly His Ile Phe Thr Asp Asn Met His Ile Gln Ala Ile Tyr Asn Ile 
                165                 170                 175     


Phe Asp Ile Glu Lys Ile Leu Ala Lys His Ile Thr Asn Ile Ile Tyr 
            180                 185                 190         


Thr Val Asn Ser Phe Asp Arg Asn Tyr Asn Gln Ser Gly Asn Asp Thr 
        195                 200                 205             


Ile Gly Phe Gly Leu Asn Tyr Arg Val Pro Tyr Ser Glu Tyr Gly Gly 
    210                 215                 220                 


Gly Lys Asp Ser Asn Gly Glu Pro Lys Asn Lys Phe Lys Trp Glu Lys 
225                 230                 235                 240 


Arg Asp Asn Phe Ser Lys Phe Tyr Asn Glu Ser Lys Pro His Leu Gly 
                245                 250                 255     


Tyr Tyr Glu Asn Ile Phe Tyr Asp His Gly Glu Pro Ile Ser Glu Glu 
            260                 265                 270         


Lys Phe Tyr Asn Tyr Leu Asn Ile Leu Asn Phe Ile Arg Asn Asn Thr 
        275                 280                 285             


Phe His Tyr Lys Asp Asn Asp Ile Glu Leu Tyr Ser Glu Asn Tyr Ser 
    290                 295                 300                 


Glu Glu Tyr Val Phe Ile Asn Cys Leu Asn Lys Phe Val Lys Asn Lys 
305                 310                 315                 320 


Phe Lys Asn Val Asn Lys Asn Phe Ile Ser Asn Glu Lys Asn Asn Leu 
                325                 330                 335     


Tyr Ile Ile Leu Asn Ala Tyr Gly Lys Asp Thr Glu Asn Val Glu Val 
            340                 345                 350         


Val Lys Lys Tyr Ser Lys Glu Leu Tyr Lys Leu Ser Val Leu Lys Thr 
        355                 360                 365             


Asn Lys Asn Leu Gly Val Asn Val Lys Lys Leu Arg Glu Ser Ala Ile 
    370                 375                 380                 


Glu Tyr Gly Tyr Cys Pro Leu Pro Tyr Asp Lys Glu Lys Glu Val Ala 
385                 390                 395                 400 


Lys Leu Ser Ser Val Lys His Lys Leu Tyr Lys Thr Tyr Asp Phe Val 
                405                 410                 415     


Ile Thr His Tyr Leu Asn Ser Asn Asp Lys Ile Leu Leu Glu Ile Val 
            420                 425                 430         


Glu Ala Leu Arg Leu Ser Lys Asn Asp Asp Glu Lys Glu Asn Val Tyr 
        435                 440                 445             


Lys Lys Tyr Ala Glu Lys Leu Phe Lys Ala Asp Asp Val Ile Asn Pro 
    450                 455                 460                 


Ile Lys Ala Ile Ser Lys Leu Phe Val Glu Lys Gly Asn Lys Leu Phe 
465                 470                 475                 480 


Lys Glu Lys Ile Ile Ile Lys Lys Glu Tyr Ile Glu Asp Val Ser Ile 
                485                 490                 495     


Asp Lys Asn Ile Tyr Asp Phe Thr Lys Val Ile Phe Phe Met Thr Cys 
            500                 505                 510         


Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Asn Ile Ile Ser 
        515                 520                 525             


Lys Leu Gln Ile Ile Glu Asp His Asn Asn Val Ile Lys Phe Ile Ser 
    530                 535                 540                 


His Asn Lys Asp Ala Val Tyr Lys Asp Tyr Ser Asp Lys Tyr Ala Ile 
545                 550                 555                 560 


Phe Arg Asn Ala Gly Lys Ile Ala Thr Glu Leu Glu Ala Ile Lys Ser 
                565                 570                 575     


Ile Ala Arg Met Glu Asn Lys Ile Glu Asn Ala Ser Gln Glu Pro Leu 
            580                 585                 590         


Leu Asn Asp Ala Leu Leu Ser Leu Gly Val Ser Asp Asp Thr Lys Val 
        595                 600                 605             


Leu Glu Asn Thr Tyr Lys Lys Tyr Phe Asp Ser Lys Glu Lys Thr Asp 
    610                 615                 620                 


Lys Gln Ser Gln Lys Val Ser Thr Phe Leu Met Asn Asn Val Ile Asn 
625                 630                 635                 640 


Asn Asn Arg Phe Lys Tyr Val Ile Lys Tyr Ile Asn Pro Ala Asp Ile 
                645                 650                 655     


Asn Gly Leu Ala Lys Asn Arg Tyr Leu Val Lys Phe Val Leu Ser Lys 
            660                 665                 670         


Ile Pro Glu Glu Gln Ile Asp Ser Tyr Tyr Lys Leu Phe Ser Asn Glu 
        675                 680                 685             


Glu Glu Pro Gly Cys Glu Glu Lys Ile Lys Leu Leu Thr Lys Lys Ile 
    690                 695                 700                 


Ser Lys Leu Asn Phe Gln Thr Leu Phe Glu Asn Asn Lys Ile Pro Asn 
705                 710                 715                 720 


Val Glu Lys Glu Lys Lys Lys Ala Ile Ile Thr Leu Tyr Phe Thr Ile 
                725                 730                 735     


Val Tyr Ile Leu Val Lys Asn Leu Val Asn Ile Asn Gly Leu Tyr Thr 
            740                 745                 750         


Leu Ala Leu Tyr Phe Val Glu Arg Asp Gly Tyr Phe Tyr Lys Asp Ile 
        755                 760                 765             


Cys Gly Lys Lys Asp Lys Lys Lys Ser Tyr Asn Asp Val Asp Tyr Leu 
    770                 775                 780                 


Leu Leu Pro Glu Ile Phe Ser Gly Ser Lys Tyr Arg Glu Glu Thr Lys 
785                 790                 795                 800 


Asn Leu Lys Leu Pro Lys Glu Lys Asp Arg Asp Ile Met Lys Lys Tyr 
                805                 810                 815     


Leu Pro Asn Asp Lys Asp Arg Glu Lys Tyr Asn Lys Phe Phe Thr Ala 
            820                 825                 830         


Tyr Arg Asn Asn Ile Val His Leu Asn Ile Ile Ala Lys Leu Ser Glu 
        835                 840                 845             


Leu Thr Lys Asn Ile Asp Lys Asp Ile Asn Ser Tyr Phe Asp Ile Tyr 
    850                 855                 860                 


His Tyr Cys Thr Gln Arg Val Met Phe Asn Tyr Cys Lys Glu Lys Asn 
865                 870                 875                 880 


Asp Val Val Leu Ala Lys Met Lys Asp Leu Ala His Ile Lys Ser Asp 
                885                 890                 895     


Cys Asn Glu Phe Ser Ser Lys His Thr Tyr Pro Phe Ser Ser Ala Val 
            900                 905                 910         


Leu Arg Phe Met Asn Leu Pro Phe Ala Tyr Asn Val Pro Arg Phe Lys 
        915                 920                 925             


Asn Leu Ser Tyr Lys Lys Phe Phe Asp Lys Gln 
    930                 935                 


<210>  3257
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3257

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Phe Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Glu Asp Ser Ser Asn Ile Glu Leu Cys Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Ile Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Ala Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Lys Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3258
<211>  923
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3258

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Val Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Glu Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asn Ser Ser Asn Ile Glu Leu Arg Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Gly Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu His Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Asp Asp Tyr 
            340                 345                 350         


Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys 
        355                 360                 365             


Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met 
    370                 375                 380                 


Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val 
385                 390                 395                 400 


Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr 
                405                 410                 415     


Tyr Arg Asn Asp Val Ile Ala Gly Glu Ala Leu Val Arg Lys Leu Arg 
            420                 425                 430         


Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala 
        435                 440                 445             


Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp 
    450                 455                 460                 


His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp 
465                 470                 475                 480 


Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu 
                485                 490                 495     


Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly 
            500                 505                 510         


Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn 
        515                 520                 525             


Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu 
    530                 535                 540                 


Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile 
545                 550                 555                 560 


Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro 
                565                 570                 575     


Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu 
            580                 585                 590         


Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys 
        595                 600                 605             


Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr 
    610                 615                 620                 


Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala 
625                 630                 635                 640 


Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met 
                645                 650                 655     


Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys 
            660                 665                 670         


Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg 
        675                 680                 685             


Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys 
    690                 695                 700                 


Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg 
705                 710                 715                 720 


Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val 
                725                 730                 735     


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys 
            740                 745                 750         


Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala 
        755                 760                 765             


Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys 
    770                 775                 780                 


Glu Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys 
785                 790                 795                 800 


Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp 
                805                 810                 815     


Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val 
            820                 825                 830         


Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser 
        835                 840                 845             


Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg 
    850                 855                 860                 


Glu Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu 
865                 870                 875                 880 


Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser 
                885                 890                 895     


Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln 
            900                 905                 910         


Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920             


<210>  3259
<211>  958
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3259

Met Gly Lys Lys Ile His Ala Arg Asp Leu Arg Glu Gln Arg Lys Thr 
1               5                   10                  15      


Asp Arg Thr Val Lys Phe Ala Asp Gln Asn Lys Lys Arg Glu Ala Glu 
            20                  25                  30          


Arg Ala Val Gln Lys Lys Asp Ala Ala Val Ser Ala Lys Ser Val Ser 
        35                  40                  45              


Ser Val Ser Ser Lys Lys Asp Asn Val Thr Lys Ser Met Ala Lys Ala 
    50                  55                  60                  


Ala Gly Val Lys Ser Val Phe Ala Val Gly Asn Thr Val Tyr Met Thr 
65                  70                  75                  80  


Ser Phe Gly Arg Gly Asn Asp Ala Val Leu Glu Gln Lys Ile Val Asp 
                85                  90                  95      


Thr Ser His Glu Pro Leu Asn Ile Asp Asp Pro Ala Tyr Gln Leu Asn 
            100                 105                 110         


Val Val Thr Met Asn Gly Tyr Ser Val Thr Gly His Arg Gly Glu Thr 
        115                 120                 125             


Val Ser Ala Val Thr Asp Asn Pro Leu Arg Arg Phe Asn Gly Gly Lys 
    130                 135                 140                 


Lys Asp Glu Pro Glu Gln Ser Val Pro Thr Asp Met Leu Cys Leu Lys 
145                 150                 155                 160 


Pro Thr Leu Glu Lys Lys Phe Phe Gly Lys Glu Phe Asn Asp Asn Ile 
                165                 170                 175     


His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala 
            180                 185                 190         


Val Tyr Ser Thr Asn Ala Ile Tyr Ala Leu Asn Asn Met Ser Ala Asp 
        195                 200                 205             


Glu Asn Ile Glu Asn Ser Asp Phe Phe Met Lys Arg Thr Thr Asp Glu 
    210                 215                 220                 


Thr Phe Asp Asp Phe Glu Lys Lys Lys Glu Ser Thr Asn Ser Arg Glu 
225                 230                 235                 240 


Lys Ala Asp Phe Asp Ala Phe Glu Lys Phe Ile Gly Asn Tyr Arg Leu 
                245                 250                 255     


Ala Tyr Phe Ala Asp Ala Phe Tyr Val Asp Lys Asn Lys Ser Lys Ser 
            260                 265                 270         


Lys Pro Lys Asp Lys Ala Lys Gly Ile Gln Arg Gly Glu Lys Glu Ile 
        275                 280                 285             


Tyr Ser Ile Leu Ala Leu Ile Ala Lys Leu Arg His Trp Cys Val His 
    290                 295                 300                 


Ser Glu Glu Gly Arg Ala Glu Phe Trp Leu Tyr Lys Leu Asp Glu Leu 
305                 310                 315                 320 


Lys Ser Asp Phe Lys Asn Val Leu Asp Val Val Tyr Asn Arg Pro Val 
                325                 330                 335     


Glu Lys Ile Asn Asn Arg Phe Ile Glu Asn Asn Lys Val Asn Ile Gln 
            340                 345                 350         


Ile Leu Gly Ser Val Tyr Lys Asn Thr Asp Ile Ala Glu Leu Val Arg 
        355                 360                 365             


Ser Tyr Tyr Glu Phe Leu Ile Thr Lys Lys Tyr Lys Asn Met Gly Phe 
    370                 375                 380                 


Ser Ile Lys Lys Leu Arg Glu Ser Met Leu Glu Gly Lys Gly Tyr Ala 
385                 390                 395                 400 


Asp Lys Glu Tyr Asp Ser Val Arg Asn Lys Leu Tyr Gln Met Thr Asp 
                405                 410                 415     


Phe Ile Leu Tyr Thr Gly Tyr Ile Asn Glu Asp Ser Asp Arg Ala Asp 
            420                 425                 430         


Asp Leu Val Asn Thr Leu Arg Ser Ser Leu Lys Glu Asp Asp Lys Thr 
        435                 440                 445             


Thr Val Tyr Cys Lys Glu Ala Asp Tyr Leu Trp Lys Lys Tyr Arg Glu 
    450                 455                 460                 


Ser Ile Arg Glu Val Ala Ala Ser Leu Asp Val Lys Asn Ile Asn Glu 
465                 470                 475                 480 


Leu Lys Asn Asn Ala Phe Thr Ile Pro Asp Asn Glu Leu Arg Lys Cys 
                485                 490                 495     


Phe Ile Ser Tyr Ala Asp Ser Val Ser Glu Phe Thr Lys Leu Ile Tyr 
            500                 505                 510         


Leu Leu Thr Arg Phe Leu Ser Gly Lys Glu Ile Asn Asp Leu Val Thr 
        515                 520                 525             


Thr Leu Ile Asn Lys Phe Asp Asn Ile Arg Ser Phe Leu Glu Val Met 
    530                 535                 540                 


Asp Glu Leu Gly Leu Glu Arg Thr Phe Thr Asp Glu Tyr Ser Phe Phe 
545                 550                 555                 560 


Glu Gly Ser Thr Lys Tyr Leu Ala Glu Leu Val Glu Leu Asn Ser Phe 
                565                 570                 575     


Val Lys Ser Cys Ser Phe Asp Ile Asn Ala Lys Arg Thr Met Tyr Arg 
            580                 585                 590         


Asp Ala Leu Asp Ile Leu Gly Ile Glu Ser Gly Lys Thr Glu Glu Asp 
        595                 600                 605             


Ile Glu Lys Met Ile Asp Asn Ile Val Gln Phe Asp Ala Asn Gly Lys 
    610                 615                 620                 


Lys Leu Pro Asn Lys Asn His Gly Leu Arg Asn Phe Ile Ala Ser Asn 
625                 630                 635                 640 


Val Ile Asp Ser Asn Arg Phe Glu Tyr Leu Val Arg Tyr Gly Asn Pro 
                645                 650                 655     


Lys Lys Ile Arg Glu Thr Ala Lys Cys Lys Pro Ala Val Arg Phe Val 
            660                 665                 670         


Leu Asn Glu Ile Pro Asp Ala Gln Ile Glu Arg Tyr Tyr Lys Ala Cys 
        675                 680                 685             


Tyr Pro Asp Glu Lys Ser Leu Cys Phe Ala Asn Met Gln Arg Asp Lys 
    690                 695                 700                 


Leu Ala Gly Val Ile Ala Asn Ile Lys Phe Asp Asp Phe Ser Asp Ala 
705                 710                 715                 720 


Gly Ser Tyr Gln Lys Ala Asn Ala Thr Ser Thr Lys Ile Thr Ser Glu 
                725                 730                 735     


Ala Glu Ile Lys Arg Lys Asn Gln Ala Ile Ile Arg Leu Tyr Leu Thr 
            740                 745                 750         


Val Met Tyr Ile Met Leu Lys Asn Leu Val Asn Val Asn Ala Arg Tyr 
        755                 760                 765             


Val Ile Ala Phe His Cys Val Glu Arg Asp Thr Lys Leu Tyr Ala Glu 
    770                 775                 780                 


Ser Gly Leu Glu Val Gly Asn Ile Glu Lys Asn Lys Thr Asn Leu Thr 
785                 790                 795                 800 


Met Ala Val Met Gly Val Lys Leu Glu Asn Gly Ile Ile Lys Thr Glu 
                805                 810                 815     


Phe Asp Lys Ser Leu Ala Glu Asn Ala Ala Asn Arg Tyr Phe Arg Asn 
            820                 825                 830         


Ala Arg Trp Tyr Lys Leu Ile Leu Asp Asn Leu Lys Lys Ser Glu Arg 
        835                 840                 845             


Ala Val Val Asn Glu Phe Arg Asn Thr Val Cys His Leu Asn Ala Ile 
    850                 855                 860                 


Arg Asn Ile Asn Ile Asn Ile Lys Glu Ile Lys Glu Val Glu Asn Tyr 
865                 870                 875                 880 


Phe Ala Leu Tyr His Tyr Leu Ile Gln Lys His Leu Glu Lys Arg Phe 
                885                 890                 895     


Ala Asp Asn Gly Gly Ser Thr Gly Asp Phe Ile Ser Lys Leu Glu Glu 
            900                 905                 910         


His Lys Thr Tyr Cys Lys Asp Phe Val Lys Ala Tyr Cys Thr Pro Phe 
        915                 920                 925             


Gly Tyr Asn Leu Val Arg Tyr Lys Asn Leu Thr Ile Asp Gly Leu Phe 
    930                 935                 940                 


Asp Lys Asn Tyr Pro Gly Lys Asp Asp Ser Asp Lys Gln Lys 
945                 950                 955             


<210>  3260
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3260

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Lys Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asp Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asp Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Glu Gly Gly Asp Glu Ser 
        195                 200                 205             


His Asp Asp Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val 
    210                 215                 220                 


Phe Thr Asn Pro Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Lys Asn 
225                 230                 235                 240 


Ile Arg Lys Ser Leu Arg Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Leu Glu Ala Tyr Lys Lys Arg Val Tyr Tyr Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Cys Val Phe His Asp Leu Ser Glu His Ser Glu Tyr 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Asn Ser Lys Lys Val Tyr Arg Glu Cys 
305                 310                 315                 320 


Arg Glu Thr Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn 
                325                 330                 335     


Lys Asp Phe Ile Glu Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp 
            340                 345                 350         


Met Met Lys Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp 
        355                 360                 365             


Phe Ile Val Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys 
385                 390                 395                 400 


Gln Tyr Asp Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu 
                405                 410                 415     


Leu Phe Cys Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu 
            420                 425                 430         


Val Arg Lys Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile 
        435                 440                 445             


Tyr Ala Asp Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe 
    450                 455                 460                 


Glu Asn Ile Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly 
465                 470                 475                 480 


Lys Thr Asp Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys 
                485                 490                 495     


Asn Ala Ser Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr 
            500                 505                 510         


Tyr Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile 
        515                 520                 525             


Ser Lys Phe Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser 
    530                 535                 540                 


Ala Val Asp Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn 
545                 550                 555                 560 


Asp Ser Gln Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala 
                565                 570                 575     


Ser Met Arg Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp 
            580                 585                 590         


Ala Leu Thr Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile 
        595                 600                 605             


Ser Glu Ile Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu 
    610                 615                 620                 


Arg Asn Phe Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr 
625                 630                 635                 640 


Leu Ile Lys Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn 
                645                 650                 655     


Glu Lys Val Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile 
            660                 665                 670         


Glu Arg Tyr Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser 
        675                 680                 685             


Leu Glu Val Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser 
    690                 695                 700                 


Phe Asp Asp Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn 
705                 710                 715                 720 


Val Ala Lys Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val 
                725                 730                 735     


Met Tyr Leu Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val 
            740                 745                 750         


Ile Ala Ile His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile 
        755                 760                 765             


Ile Pro Glu Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu 
    770                 775                 780                 


Ser Gln Thr Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Asn Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asp Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  3261
<211>  924
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3261

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Gly Ser Gly Met Lys 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Glu Ser Asn Tyr Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe Thr Asn Pro 
    210                 215                 220                 


Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Glu Asn Ile Arg Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Leu Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Cys Val Phe His Asp Leu Ser Glu His Ser Glu Tyr Asp Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asp Asn Ser Lys Lys Val Tyr Arg Glu Cys Arg Glu Thr Leu 
305                 310                 315                 320 


Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile 
                325                 330                 335     


Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly 
            340                 345                 350         


Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu 
        355                 360                 365             


Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys 
    370                 375                 380                 


Ile Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser 
385                 390                 395                 400 


Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn 
                405                 410                 415     


Tyr Tyr Arg Asn Asp Ile Ala Ala Gly Glu Ser Leu Val Arg Lys Leu 
            420                 425                 430         


Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu 
        435                 440                 445             


Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala 
    450                 455                 460                 


Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met 
465                 470                 475                 480 


Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp 
                485                 490                 495     


Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp 
            500                 505                 510         


Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp 
        515                 520                 525             


Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val 
    530                 535                 540                 


Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg 
545                 550                 555                 560 


Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys 
                565                 570                 575     


Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile 
            580                 585                 590         


Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu 
        595                 600                 605             


Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile 
    610                 615                 620                 


Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr 
625                 630                 635                 640 


Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val 
                645                 650                 655     


Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr 
            660                 665                 670         


Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys 
        675                 680                 685             


Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe 
    690                 695                 700                 


Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu 
705                 710                 715                 720 


Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu 
                725                 730                 735     


Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His 
            740                 745                 750         


Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu 
        755                 760                 765             


Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu 
    770                 775                 780                 


Cys Glu Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys 
785                 790                 795                 800 


Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala 
                805                 810                 815     


Asp Ser Asn Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr 
            820                 825                 830         


Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp 
        835                 840                 845             


Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys 
    850                 855                 860                 


Arg Glu Asp Asp Thr Lys Gln Glu Glu Ile Ile Lys Tyr Glu Asp Asp 
865                 870                 875                 880 


Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn 
                885                 890                 895     


Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu 
            900                 905                 910         


Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 


<210>  3262
<211>  960
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3262

Met Ala Lys Lys Leu Asn Ala Lys Glu Lys Arg Leu Leu Ser Gln Gln 
1               5                   10                  15      


Ala Gln Lys Asp Lys Tyr Lys Lys Met Glu Glu Glu Arg Gln Ala Ala 
            20                  25                  30          


Glu Gln Ala Arg Leu Ala Glu Glu Ala Arg Gln Lys Ala Glu Thr Glu 
        35                  40                  45              


Arg Lys Lys Lys Glu Ala Leu Glu Lys Glu Ala Arg Glu Lys Leu Glu 
    50                  55                  60                  


Lys Glu Leu Leu Glu Lys Asn Pro Ser Leu Lys Lys Val Lys Lys Ser 
65                  70                  75                  80  


Lys Ala Lys Ala Ala Gly Leu Lys Ser Thr Phe Ala Ile Gly Asn Glu 
                85                  90                  95      


Leu Leu Met Thr Ser Phe Gly Lys Gly Asn Glu Ala Val Pro Glu His 
            100                 105                 110         


Tyr Ile Phe Glu Asn Gly Met Ile Ser Met Gln Asn Pro Pro Ala Phe 
        115                 120                 125             


Asp Val Glu Asn Arg Gly Thr Ser Phe Ser Ile Ala Gly Lys Asn Ala 
    130                 135                 140                 


Met Asn Ala Ile Ala Asp Asp Pro Arg Arg Thr Ser Lys Lys Val Ile 
145                 150                 155                 160 


Gly Glu Asp Leu Ile Gly Ala Lys Ser Ala Leu Glu Lys Arg Tyr Phe 
                165                 170                 175     


Gly Lys Thr Phe Glu Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
            180                 185                 190         


Leu Asp Ile Glu Lys Ile Leu Ser Lys His Ile Asn Asn Ile Val Phe 
        195                 200                 205             


Ser Ile Asn Asn Ile Arg Gly Ile Ala Asp Pro Glu Arg Asp Asp Leu 
    210                 215                 220                 


Ile Gly Tyr Met Ser Leu Arg Asp Ser Tyr Glu Tyr Phe Met Asp Glu 
225                 230                 235                 240 


Lys Asn Glu Lys Arg Lys Val Leu Arg Glu Ser Tyr Arg Lys Leu Phe 
                245                 250                 255     


Lys Ser Ser Arg Leu Ser Tyr Phe Gly Ser Ala Phe Tyr Val Glu Lys 
            260                 265                 270         


Gln Ser Thr Gln Lys Lys Lys Ser Gly Gln Lys Asn Phe Glu Leu Arg 
        275                 280                 285             


Asn Glu Lys Asp Cys Tyr Tyr Met Leu Ala Leu Leu Gly Glu Leu Arg 
    290                 295                 300                 


Gln Val Leu Ala His Ser Ser Thr Gln Lys Gln Gly Lys Glu Gln Thr 
305                 310                 315                 320 


Glu Ala Arg Ser Ser Val Tyr Asn Leu Arg Thr Val Gly Asn Asn Asp 
                325                 330                 335     


Met Arg Lys Ile Leu Asn Ser Leu Tyr Ala Glu Arg Val Asp Ala Leu 
            340                 345                 350         


Asn Glu Asn Phe Met Asn Tyr Ala Lys Lys Asp Leu Thr Ile Leu Phe 
        355                 360                 365             


Gly Ile Met Asp Ala Ser Ser Tyr Glu Lys Lys Ala Glu Ile Ala Arg 
    370                 375                 380                 


Asp Phe Tyr Asp Phe Thr Val Arg Lys Ser Tyr Lys Asn Ile Gly Phe 
385                 390                 395                 400 


Ser Ile Lys Lys Ile Arg Glu Arg Met Met Asp Cys Phe Phe Ala Asn 
                405                 410                 415     


Val Lys Glu Ile Thr Pro Asp Ser Pro Asp Phe Gln Ser Val Arg Gln 
            420                 425                 430         


Lys Phe Tyr Lys Ile Leu Asp Phe Leu Leu Phe Thr Tyr Tyr Lys Asp 
        435                 440                 445             


Asn Lys Glu Glu Thr Lys Lys Ile Ile Ala Ala Leu Arg Ala Ser Leu 
    450                 455                 460                 


Thr Glu Leu Glu Lys Glu Leu Phe Tyr Gln Lys Gln Ala Asn Ile Leu 
465                 470                 475                 480 


Trp Asn Lys Met Gln Met Val Val Thr Glu Gln Ile Tyr Pro Arg Thr 
                485                 490                 495     


Lys Gly Ser Ala Ile Gln Asn Leu Ile Ala Asp Pro Glu Ile Ser Ala 
            500                 505                 510         


Asp Met Leu Lys Gly Val Met Ile Thr Pro Glu Ser Val Asp Tyr Phe 
        515                 520                 525             


Ser Lys Met Ile Tyr Leu Leu Thr Leu Phe Ile Asp Gly Lys Glu Ile 
    530                 535                 540                 


Asn Asp Leu Leu Thr Thr Met Ile Asn Lys Phe Glu Asn Ile Ala Ser 
545                 550                 555                 560 


Phe Val Ser Val Leu Lys Asp Arg Gly Leu Pro Cys Asn Phe Arg Asn 
                565                 570                 575     


Asp Tyr Ser Val Phe Asn Asn Ala Leu Lys Ile Ser Ala Glu Leu Arg 
            580                 585                 590         


Glu Ile Asn Ser Phe Ala Arg Met Glu Lys Ala Thr Pro Gly Ala Lys 
        595                 600                 605             


Lys Gln Met Phe Leu Asp Ala Ala Ile Ile Leu Gly Ser Asn Glu Ser 
    610                 615                 620                 


Ala Glu Glu Leu Ser Glu Tyr Phe Asp Glu Met Leu Asp Lys Gln Lys 
625                 630                 635                 640 


Gly Lys Arg Thr Pro Gly Gly Lys Lys Asp Met Gly Phe Arg Asn Phe 
                645                 650                 655     


Leu Ile Lys Asn Val Ile Glu Ser Asp Arg Phe His Tyr Leu Ile Arg 
            660                 665                 670         


Tyr Gly His Pro Leu His Ile Arg Lys Leu Ala Glu Asn Lys Asn Val 
        675                 680                 685             


Ile Ala Phe Val Leu Lys Gln Ile Pro Glu Pro Gln Ile Asp Arg Tyr 
    690                 695                 700                 


Cys Lys Ile Cys Ala Leu Pro Ala Glu Ser Asn Phe Ala Gln Lys Ile 
705                 710                 715                 720 


Leu Arg Leu Thr Asp Leu Ile Ala Glu Met Asn Phe Arg Gln Phe Glu 
                725                 730                 735     


Asn Val Arg Gln Thr Glu Lys Asn Glu Gln Lys Gln Ile Leu Gln Gly 
            740                 745                 750         


Ile Leu Ser Leu Tyr Leu Thr Val Leu Tyr Leu Leu Thr Lys Asn Leu 
        755                 760                 765             


Val Tyr Val Asn Ser Arg Tyr Phe Leu Ala Phe His Cys Leu Glu Arg 
    770                 775                 780                 


Asp Thr Glu Leu Leu Gly Ser Gln Ala Gly His Lys Asn Ala Glu Lys 
785                 790                 795                 800 


Gln Leu Ile Ala Ser Tyr Ser Ala Leu Thr Gln Gln Phe Leu Asp Glu 
                805                 810                 815     


Gly Lys Leu Asn Arg His Ala Arg Glu Tyr Leu Thr Val Asn Ile Gln 
            820                 825                 830         


Asn Ser Asp Asp Trp Thr Ile Ala Gln Tyr Arg Asn Asn Ala Ala His 
        835                 840                 845             


Leu Asn Ala Ile Arg Asn Ala His Leu Tyr Ile Arg Glu Met Lys Ser 
    850                 855                 860                 


Val Arg Ser Tyr Phe Glu Leu Tyr His Tyr Leu Thr Gln Arg Ala Leu 
865                 870                 875                 880 


Leu Asp Lys Tyr Glu Asn Val Pro Tyr His Pro Gln Val Asn Glu Lys 
                885                 890                 895     


Thr Leu Lys Tyr Phe Glu Leu Leu Lys Glu Asn Gly Trp Tyr Cys Lys 
            900                 905                 910         


Asp Phe Val Lys Ala Leu Asn Val Pro Phe Gly Tyr Asn Leu Pro Arg 
        915                 920                 925             


Tyr Lys Asn Leu Ser Ile Asp Ala Leu Phe Asp Lys Asp Arg Pro Gln 
    930                 935                 940                 


Glu Glu Asp Glu Asn His Leu Tyr Thr Cys Gln Asn Ile Lys Lys Ser 
945                 950                 955                 960 


<210>  3263
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3263

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Asp Gly Ser Ser Asn Ile Glu Leu Arg Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Asp Glu Ser His Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe Thr Asp 
    210                 215                 220                 


Pro Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Asn Ala Leu Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Pro Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp Asp Ile 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  3264
<211>  926
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3264

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Lys Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asn Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Asp Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Lys Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile Asn Lys 
225                 230                 235                 240 


Val Lys Gly Asn Ile Lys Lys Ser Phe Ser Thr Phe Asn Asp Leu Leu 
                245                 250                 255     


Lys Thr Lys Arg Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys 
            260                 265                 270         


Asp Thr Arg Val Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu 
        275                 280                 285             


Ala Ile Val Gly Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Ser 
    290                 295                 300                 


Lys Leu His Glu Asp Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu 
305                 310                 315                 320 


Tyr Arg Glu Thr Leu Asp Tyr Leu Val Asp Glu Arg Phe Glu Ser Ile 
                325                 330                 335     


Asn Lys Gly Phe Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile 
            340                 345                 350         


Asp Met Met Lys Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr 
        355                 360                 365             


Asp Phe Ile Val Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys 
    370                 375                 380                 


Lys Leu Arg Glu Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp 
385                 390                 395                 400 


Lys Gln Tyr Asp Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe 
                405                 410                 415     


Leu Leu Phe Cys Asn Tyr Tyr Arg Asn Asp Val Ile Ala Gly Glu Ala 
            420                 425                 430         


Leu Val Arg Lys Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly 
        435                 440                 445             


Ile Tyr Ala Asp Glu Ala Ser Lys Leu Trp Gly Lys Phe Arg Asn Asp 
    450                 455                 460                 


Phe Glu Asn Ile Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu 
465                 470                 475                 480 


Gly Lys Ala Asp Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys 
                485                 490                 495     


Lys Asn Ala Ser Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu 
            500                 505                 510         


Thr Tyr Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu 
        515                 520                 525             


Ile Ser Lys Phe Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser 
    530                 535                 540                 


Ser Ala Val Asp Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe 
545                 550                 555                 560 


Asn Asp Ser Gln Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile 
                565                 570                 575     


Ala Ser Met Arg Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg 
            580                 585                 590         


Asp Ala Leu Thr Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg 
        595                 600                 605             


Ile Ser Glu Ile Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly 
    610                 615                 620                 


Leu Arg Asn Phe Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val 
625                 630                 635                 640 


Tyr Leu Ile Lys Tyr Ala Asn Ala Gln Lys Ile Arg Lys Val Ala Glu 
                645                 650                 655     


Asn Glu Lys Val Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln 
            660                 665                 670         


Ile Glu Arg Tyr Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser 
        675                 680                 685             


Ser Leu Glu Val Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile 
    690                 695                 700                 


Ser Phe Asp Asp Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu 
705                 710                 715                 720 


Asn Val Ala Lys Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr 
                725                 730                 735     


Val Met Tyr Leu Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr 
            740                 745                 750         


Val Ile Ala Ile His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu 
        755                 760                 765             


Ile Ile Pro Glu Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile 
    770                 775                 780                 


Leu Ser Gln Thr Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe 
785                 790                 795                 800 


Leu Lys Lys Asn Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn 
                805                 810                 815     


Asn Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His 
            820                 825                 830         


Leu Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr 
        835                 840                 845             


Val Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile 
    850                 855                 860                 


Thr Lys Arg Glu Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu 
865                 870                 875                 880 


Asp Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala 
                885                 890                 895     


Leu Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser 
            900                 905                 910         


Ile Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925     


<210>  3265
<211>  946
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3265

Met Lys Lys Phe Ser Asn Ile Lys Arg Leu Gly Val Lys Ser Val His 
1               5                   10                  15      


Tyr Ala Asn Asn Thr Val Ile Val Glu Asp His Phe Ser Lys Asn Thr 
            20                  25                  30          


Asn Ile Leu Phe Thr Ala Glu Tyr Glu Asn Ile Asp Asp Leu Lys Ser 
        35                  40                  45              


Cys Thr Asn Ile Asp Lys Thr Ala Glu Asn Lys Gly Val Arg Phe Thr 
    50                  55                  60                  


Asp Leu Lys Asn Lys Asn Gly Phe Glu Leu Ser Ala Met Ala Gln Lys 
65                  70                  75                  80  


Gln Ile Leu Lys Ser Arg Val Asn Arg Val Lys Lys Val Ser Tyr Thr 
                85                  90                  95      


Gln Glu Leu Phe Asp Ile Thr Thr Asp Asn Asn Ile Glu Val Gln Ile 
            100                 105                 110         


Phe Ser Asn Leu Glu Asp Val Lys Lys Val Ile Ala Pro Tyr Tyr Asn 
        115                 120                 125             


Asn Val Ala Tyr Ala Ile Asn Ser Leu Tyr Arg Asp Ile Ser Asn Asp 
    130                 135                 140                 


Asp Ser Tyr Gly Phe Asp Lys Ile Gly Ser Ile Pro Val Asp Ala Asp 
145                 150                 155                 160 


Trp Tyr Asn Phe Leu Lys Asp Ala Pro Asp Lys Lys Glu Lys Trp Thr 
                165                 170                 175     


Thr Tyr Ile Ile Pro Ser Tyr Lys Lys Val Ile Ala Arg Phe Gly Ile 
            180                 185                 190         


Gln Met Glu Lys Asn Gln Gln Val Asn Phe Cys Lys Cys Leu Glu Tyr 
        195                 200                 205             


Val Ala Ile Arg Asn Gly Leu Phe Val Lys Phe Lys Asp Glu Lys Val 
    210                 215                 220                 


Asp Pro Asp Lys Leu Leu Asn Lys Lys Ile Gln Glu Lys Leu Asp Lys 
225                 230                 235                 240 


Leu Ile Ser Asp Lys Glu Val Asn Asp Lys Leu Phe Glu Leu Ala Lys 
                245                 250                 255     


Thr Pro Val Ser Glu Phe Cys Ala Glu Ala Asn Ala Ile Pro Leu Tyr 
            260                 265                 270         


Arg Tyr Ala Phe Ile Gly Gln Lys Gly Lys Arg Ile Glu Lys Ile Val 
        275                 280                 285             


Leu Asp Lys Leu Glu Glu Asn Glu Ile Leu Ser Ser Leu Val Arg Lys 
    290                 295                 300                 


Ile Asp Glu Asn Glu Thr Thr Tyr Asn Tyr Leu Arg Leu Leu Ser Ala 
305                 310                 315                 320 


Ile Arg Gln Tyr Val Val His Asn Ser Arg Lys Val Arg Ile Asp Lys 
                325                 330                 335     


Asn Val Phe Ile Asn Asp Thr Ala Lys Arg Asp Val Glu Glu Phe Ala 
            340                 345                 350         


Lys Gln Phe Gln Lys Asn Asn Tyr Lys Tyr Phe Cys Ile Leu Lys Glu 
        355                 360                 365             


Leu Tyr Ser Asp Ser Asp Ile Leu Glu Gln Phe Phe Asp Tyr Thr Val 
    370                 375                 380                 


Phe Asp Glu Ala Arg Asn Leu Lys Ile Ser Ile Asp Lys Ile Lys Lys 
385                 390                 395                 400 


Gly Ile Thr Ala Asn Ile Asp Ile Ser Ala Asp Val Glu Pro Asp Lys 
                405                 410                 415     


Leu Ser Glu Tyr Ala Asn Lys Phe Arg Thr Val Thr Met Phe Ala Leu 
            420                 425                 430         


Thr Lys Tyr Leu Lys Glu Asn Val Gly Glu Ile Glu Asp Phe Leu Ala 
        435                 440                 445             


Asn Ile Lys Val Cys Ser Ser Asp Glu Glu Lys Ala Gly Val Tyr Glu 
    450                 455                 460                 


Gln Lys Ala Lys Glu Phe Ile Thr Lys Phe Asp Ser Phe Lys Asp Ile 
465                 470                 475                 480 


Arg Ser Val Val Lys Lys His Leu Gly Thr Gln Lys Val Asn Glu Lys 
                485                 490                 495     


Phe Asp Phe Tyr Pro Ser Asp Ile Asn Phe Gly Arg Asp Ser Asn Val 
            500                 505                 510         


Phe Phe Asn Met Leu Tyr Val Met Ser Lys Phe Leu Thr Val Asn Glu 
        515                 520                 525             


Ala Arg Ile Met Phe Gln Lys Ile Lys Ser Lys Tyr Asp Ser Val Lys 
    530                 535                 540                 


Ser Leu Leu Lys Ile Ala Glu Leu Thr Gly Val Thr Leu Ser Asp Asn 
545                 550                 555                 560 


Leu Phe Asp Arg Phe Arg Met Ile Phe Asp Lys Glu Arg Val Asp Glu 
                565                 570                 575     


Tyr Gln Lys Gln Leu Ile Val Leu Gln Ser Ile Arg Thr Arg Asn Gly 
            580                 585                 590         


Val Ser Gln Glu Gly Phe Ala Lys Glu Leu Lys Arg Ile Phe Asp Met 
        595                 600                 605             


Phe Lys Lys Asp Asp Ile Ser Tyr Glu Glu Phe Glu Lys Glu Leu Ser 
    610                 615                 620                 


Leu Asp Glu Asn Gln Asn Glu Ile Lys Asn Lys Ser Phe Lys Leu Lys 
625                 630                 635                 640 


Pro Leu Lys Ser Tyr Leu Arg Asn Asp Val Tyr Lys Ser Lys Gln Tyr 
                645                 650                 655     


Gln Tyr Ile Ser Ser Phe Ala Ser Ala Gly Ile Cys Gln Lys Ile Met 
            660                 665                 670         


Glu Asn Lys Asp Ile Val Ala Phe Val Leu Asn Gly Met Leu Tyr Gln 
        675                 680                 685             


Glu Gly Lys Leu Ser Met Pro Met His Lys Tyr Val Ala Lys Val Tyr 
    690                 695                 700                 


His Asp Phe Arg Arg Glu Lys Ile Asp Glu Asn Ser Ala Asn Tyr Leu 
705                 710                 715                 720 


Leu Asp Gln Asn Gln Ile Ser Ser Leu Val Asn Ser Leu Cys Asp Leu 
                725                 730                 735     


Lys Leu Glu Asn Ile Ile Glu Ala Ile Phe Lys Glu Ser Arg Val Asn 
            740                 745                 750         


Tyr Lys Ala Leu Val Arg Leu Tyr Leu Asn Ile Cys Tyr Leu Phe Val 
        755                 760                 765             


Lys Asn Ile Ile Ser Leu Asn Ser Thr Tyr Leu Ile Gln Phe Gln Asp 
    770                 775                 780                 


Tyr Glu Asn Ile Tyr Lys Gln Leu His Leu Glu Asp Leu Met Asp Ile 
785                 790                 795                 800 


Thr Tyr Asp Phe Gly Val Leu Asn Asn Phe Val Glu Asn Ala Pro Asn 
                805                 810                 815     


Lys Lys Cys Arg Ser Tyr Met Gln Leu Gln Thr Leu Leu Glu Lys Asp 
            820                 825                 830         


Tyr Ile Lys Asp Tyr Ile Tyr Thr Pro Glu Tyr Gln Val Leu Gln Asp 
        835                 840                 845             


Arg Tyr Arg Asn Leu Val Val His Ser Ser Leu Leu Phe Gly Leu Asp 
    850                 855                 860                 


Lys Ile Asp Phe Asp Phe Gly Glu Val Gln Asn Ile Ser Ser Tyr Phe 
865                 870                 875                 880 


Ala Ile Tyr Gln Thr Leu Val Gln Arg Leu Val Glu Gln Asp Ala Arg 
                885                 890                 895     


Glu Val Trp Gly Glu Lys Phe Asp Glu Tyr Phe Ala Leu Asn Asn Gly 
            900                 905                 910         


Lys Thr Tyr Ser Thr Lys Leu Cys Ile Ala Leu Asn Met Pro Tyr Ala 
        915                 920                 925             


Tyr Asn Ile Ser Arg Phe Asn Asn Asn Thr Ile Glu Lys Tyr Ser Asn 
    930                 935                 940                 


Lys Arg 
945     


<210>  3266
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3266

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Phe 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Glu Asp Ser Ser Asn Ile Glu Leu Cys Gly Val Thr Lys 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Leu Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Lys Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Ala Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Lys Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Lys 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Ile Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Glu 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Gln Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Ser Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Val Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asp Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp Asp Thr 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  3267
<211>  939
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3267

Met Ala Lys Lys Lys Arg Ile Thr Ala Lys Glu Arg Lys Gln Asn His 
1               5                   10                  15      


Arg Glu Ser Leu Met Lys Lys Ala Asp Ser Asn Ala Glu Lys Glu Lys 
            20                  25                  30          


Ala Lys Lys Pro Val Val Glu Asn Lys Pro Asp Thr Ala Ile Ser Lys 
        35                  40                  45              


Asp Asn Thr Pro Lys Pro Asn Lys Glu Ile Lys Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Ala Gly Val Lys Trp Val Ile Lys Ala Asn Asp Asp Val Ala Tyr 
65                  70                  75                  80  


Ile Ser Ser Phe Gly Lys Gly Asn Asn Ser Val Leu Glu Lys Arg Ile 
                85                  90                  95      


Met Gly Asp Val Ser Ser Asn Val Asn Lys Asp Ser His Met Tyr Val 
            100                 105                 110         


Asn Pro Lys Tyr Thr Lys Lys Asn Tyr Glu Ile Lys Asn Gly Phe Ser 
        115                 120                 125             


Ser Gly Ser Ser Leu Val Thr Tyr Pro Asn Lys Pro Asp Lys Asn Ser 
    130                 135                 140                 


Gly Met Asp Ala Leu Cys Leu Lys Pro Tyr Phe Glu Lys Asp Phe Phe 
145                 150                 155                 160 


Gly His Ile Phe Thr Asp Asn Met His Ile Gln Ala Ile Tyr Asn Ile 
                165                 170                 175     


Phe Asp Ile Glu Lys Ile Leu Ala Lys His Ile Thr Asn Ile Ile Tyr 
            180                 185                 190         


Thr Val Asn Ser Phe Asp Arg Asn Tyr Asn Gln Ser Gly Asn Asp Thr 
        195                 200                 205             


Ile Gly Phe Asp Ile Asn Tyr Arg Val Pro Tyr Ser Glu Tyr Gly Gly 
    210                 215                 220                 


Gly Lys Asp Ser Asn Gly Glu Pro Lys Asn Gln Ser Lys Trp Lys Lys 
225                 230                 235                 240 


Arg Lys Asn Phe Ile Lys Phe Tyr Asn Lys Ser Lys Pro His Leu Gly 
                245                 250                 255     


Tyr Tyr Glu Asn Ile Phe Tyr Asp His Gly Glu Pro Ile Ser Glu Glu 
            260                 265                 270         


Lys Phe Tyr Asn Tyr Leu Asn Ile Leu Asn Phe Ile Arg Asn Asn Thr 
        275                 280                 285             


Phe His Tyr Lys Asp Asn Asp Ile Glu Leu Tyr Gly Glu Asn Tyr Ser 
    290                 295                 300                 


Glu Glu Tyr Val Phe Ile Asn Cys Leu Asn Glu Phe Val Lys Asn Lys 
305                 310                 315                 320 


Phe Lys Asn Val Asn Lys Asn Phe Ile Ser Asn Glu Lys Asn Asn Leu 
                325                 330                 335     


Tyr Ile Ile Leu Lys Ala Tyr Gly Glu Asp Thr Glu Asn Val Glu Val 
            340                 345                 350         


Val Lys Lys Tyr Ser Lys Glu Leu Tyr Lys Leu Ser Val Leu Lys Thr 
        355                 360                 365             


Asn Lys Asn Leu Gly Val Asn Val Lys Lys Leu Arg Glu Ser Ala Ile 
    370                 375                 380                 


Glu Tyr Gly Tyr Cys Pro Leu Pro Tyr Asp Lys Glu Lys Glu Val Ala 
385                 390                 395                 400 


Lys Leu Ser Ser Val Lys His Lys Leu Tyr Lys Thr Tyr Asp Phe Val 
                405                 410                 415     


Ile Thr His Tyr Leu Asn Ser Asn Asp Lys Leu Leu Leu Glu Ile Val 
            420                 425                 430         


Glu Thr Leu Arg Leu Ser Lys Asn Asp Asp Glu Lys Glu Asn Val Tyr 
        435                 440                 445             


Lys Lys Tyr Ala Glu Lys Leu Phe Lys Ala Asp Asp Val Ile Asn Pro 
    450                 455                 460                 


Ile Lys Ala Ile Ser Lys Leu Phe Ala Glu Lys Gly Asn Lys Leu Phe 
465                 470                 475                 480 


Lys Glu Lys Ile Ile Ile Lys Lys Glu Tyr Ile Glu Asp Val Ser Ile 
                485                 490                 495     


Asp Lys Asn Ile Tyr Asp Phe Thr Lys Val Ile Phe Phe Met Thr Cys 
            500                 505                 510         


Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Asn Ile Ile Ser 
        515                 520                 525             


Lys Leu Gln Ile Ile Glu Asp His Asn Asn Val Ile Lys Phe Ile Ala 
    530                 535                 540                 


Glu Asn Asp Asp Ala Val Tyr Lys Asp Tyr Ser Asp Lys Tyr Ala Ile 
545                 550                 555                 560 


Phe Arg Asn Ala Gly Lys Ile Ala Thr Glu Leu Glu Ala Ile Lys Ser 
                565                 570                 575     


Ile Ala Arg Met Glu Asn Lys Ile Glu Asn Val Pro Gln Lys Pro Leu 
            580                 585                 590         


Leu Lys Asp Ala Leu Leu Ser Leu Gly Val Ser Asp Asp Thr Lys Val 
        595                 600                 605             


Leu Glu Asn Thr Tyr Asn Lys Tyr Phe Asp Ser Lys Glu Lys Ala Asp 
    610                 615                 620                 


Lys Gln Ser Gln Lys Val Ser Thr Phe Leu Met Asn Asn Val Ile Asn 
625                 630                 635                 640 


Asn Asn Arg Phe Lys Tyr Val Ile Lys Tyr Ile Asn Pro Ala Asp Ile 
                645                 650                 655     


Asn Gly Leu Ala Lys Asn Arg Tyr Leu Val Lys Phe Val Leu Ser Lys 
            660                 665                 670         


Ile Pro Glu Glu Gln Ile Asp Ser Tyr Tyr Lys Leu Phe Ser Asn Glu 
        675                 680                 685             


Glu Glu Pro Ser Cys Glu Glu Lys Ile Lys Leu Leu Thr Lys Lys Ile 
    690                 695                 700                 


Ser Lys Leu Asn Phe Gln Thr Leu Phe Glu Asn Asn Lys Ile Pro Asn 
705                 710                 715                 720 


Val Glu Lys Glu Arg Lys Lys Ala Ile Ile Thr Leu Tyr Phe Thr Ile 
                725                 730                 735     


Val Tyr Ile Leu Val Lys Asn Leu Val Asn Ile Asn Gly Leu Tyr Thr 
            740                 745                 750         


Leu Ala Leu Tyr Phe Val Glu Arg Asp Gly Tyr Phe Tyr Lys Asp Ile 
        755                 760                 765             


Cys Gly Lys Lys Asp Lys Lys Lys Ser Tyr Asn Asp Val Asp Tyr Leu 
    770                 775                 780                 


Leu Leu Ser Glu Ile Phe Ser Gly Ser Lys Tyr Arg Glu Glu Thr Lys 
785                 790                 795                 800 


Asn Leu Lys Leu Pro Lys Glu Lys Asp Arg Asp Ile Met Lys Lys Tyr 
                805                 810                 815     


Leu Pro Asn Asp Lys Asp Arg Glu Lys Tyr Asn Lys Phe Phe Thr Ala 
            820                 825                 830         


Tyr Arg Asn Asn Ile Val His Leu Asn Ile Ile Ala Lys Leu Ser Glu 
        835                 840                 845             


Leu Thr Ser Asn Ile Asp Lys Asp Ile Asn Ser Tyr Phe Asp Ile Tyr 
    850                 855                 860                 


His Tyr Cys Thr Gln Arg Val Met Phe Asp Tyr Cys Lys Lys Asn Asn 
865                 870                 875                 880 


Asn Val Val Leu Ala Lys Met Lys Asp Leu Ala His Ile Lys Ser Asp 
                885                 890                 895     


Cys Asp Glu Phe Ser Ser Lys His Thr Tyr Pro Phe Ser Ser Ala Val 
            900                 905                 910         


Leu Arg Phe Met Asn Leu Pro Phe Ala Tyr Asn Val Pro Arg Phe Lys 
        915                 920                 925             


Asn Leu Ser Tyr Lys Lys Phe Phe Asp Lys Gln 
    930                 935                 


<210>  3268
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3268

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Phe Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Asn Arg Val Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Ile Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Leu Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Lys Val Ala Glu Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp Asp Lys 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Phe Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  3269
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3269

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Phe Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Asn Arg Val Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Ile Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Leu Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Lys Val Ala Glu Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp Asp Lys 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Phe Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  3270
<211>  926
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3270

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Val Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Lys Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asp Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asp Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Lys Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Asn Ala 
            260                 265                 270         


Leu Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu His Glu 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Asp Asp Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile 
        355                 360                 365             


Val Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg 
    370                 375                 380                 


Glu Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe 
                405                 410                 415     


Cys Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg 
            420                 425                 430         


Lys Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala 
        435                 440                 445             


Asp Glu Ala Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn 
    450                 455                 460                 


Ile Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala 
465                 470                 475                 480 


Asp Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala 
                485                 490                 495     


Ser Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe 
            500                 505                 510         


Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys 
        515                 520                 525             


Phe Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val 
    530                 535                 540                 


Asn Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser 
545                 550                 555                 560 


Gln Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met 
                565                 570                 575     


Arg Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu 
            580                 585                 590         


Thr Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu 
        595                 600                 605             


Ile Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn 
    610                 615                 620                 


Phe Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile 
625                 630                 635                 640 


Lys Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys 
                645                 650                 655     


Val Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg 
            660                 665                 670         


Tyr Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu 
        675                 680                 685             


Ala Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp 
    690                 695                 700                 


Asp Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala 
705                 710                 715                 720 


Lys Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr 
                725                 730                 735     


Leu Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala 
            740                 745                 750         


Ile His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro 
        755                 760                 765             


Glu Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln 
    770                 775                 780                 


Thr Leu Cys Glu Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe 
785                 790                 795                 800 


Leu Lys Lys Asn Arg Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn 
                805                 810                 815     


Asn Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His 
            820                 825                 830         


Leu Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr 
        835                 840                 845             


Val Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile 
    850                 855                 860                 


Thr Lys Arg Glu Asp Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu 
865                 870                 875                 880 


Asp Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala 
                885                 890                 895     


Leu Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser 
            900                 905                 910         


Ile Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925     


<210>  3271
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3271

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asp Asn Asp Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asn 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Ser Val Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Gln Asn Thr Tyr Tyr Ile 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val 
            260                 265                 270         


Ser Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu 
    290                 295                 300                 


Tyr Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Val Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Ile Ala Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Leu Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3272
<211>  960
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3272

Met Ala Lys Lys Leu Asn Ala Lys Glu Lys Arg Leu Leu Ser Gln Gln 
1               5                   10                  15      


Ala Gln Lys Asp Lys Tyr Lys Lys Met Glu Glu Glu Arg Gln Ala Ala 
            20                  25                  30          


Glu Gln Ala Arg Leu Ala Glu Glu Ala Arg Gln Lys Ala Glu Thr Glu 
        35                  40                  45              


Arg Lys Lys Lys Glu Ala Leu Glu Lys Glu Ala Arg Glu Lys Leu Glu 
    50                  55                  60                  


Lys Glu Leu Leu Glu Lys Asn Pro Ser Leu Lys Lys Val Lys Lys Ser 
65                  70                  75                  80  


Lys Ala Lys Ala Ala Gly Leu Lys Ser Thr Phe Ala Ile Gly Asn Glu 
                85                  90                  95      


Leu Leu Met Thr Ser Phe Gly Lys Gly Asn Glu Ala Val Pro Glu His 
            100                 105                 110         


Tyr Ile Phe Glu Asn Gly Met Ile Ser Met Gln Asn Pro Pro Ala Phe 
        115                 120                 125             


Asp Val Glu Asn Arg Gly Thr Ser Phe Ser Ile Ala Gly Lys Asn Ala 
    130                 135                 140                 


Met Asn Ala Ile Ala Asp Asp Pro Arg Arg Thr Ser Lys Lys Val Ile 
145                 150                 155                 160 


Gly Glu Asp Leu Ile Gly Ala Lys Ser Ala Leu Glu Lys Arg Tyr Phe 
                165                 170                 175     


Gly Lys Thr Phe Glu Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
            180                 185                 190         


Leu Asp Ile Glu Lys Ile Leu Ser Lys His Ile Asn Asn Ile Val Phe 
        195                 200                 205             


Ser Ile Asn Asn Ile Arg Gly Ile Ala Asp Pro Glu Arg Asp Asp Leu 
    210                 215                 220                 


Ile Gly Tyr Met Ser Leu Arg Asp Ser Tyr Glu Tyr Phe Met Asp Glu 
225                 230                 235                 240 


Lys Asn Glu Lys Arg Lys Val Leu Arg Glu Ser Tyr Arg Lys Leu Phe 
                245                 250                 255     


Lys Ser Ser Arg Leu Ser Tyr Phe Gly Ser Ala Phe Tyr Val Glu Lys 
            260                 265                 270         


Gln Ser Thr Gln Lys Lys Lys Ser Gly Gln Lys Asn Phe Glu Leu Arg 
        275                 280                 285             


Asn Glu Lys Asp Cys Tyr Tyr Met Leu Ala Leu Leu Gly Glu Leu Arg 
    290                 295                 300                 


Gln Val Leu Ala His Ser Ser Ala Gln Lys Gln Gly Lys Glu Gln Thr 
305                 310                 315                 320 


Glu Ala Arg Ser Ser Val Tyr Asn Leu Arg Thr Val Gly Asn Asn Asp 
                325                 330                 335     


Met Arg Lys Ile Leu Asn Ser Leu Tyr Ala Glu Arg Val Asp Ala Leu 
            340                 345                 350         


Asn Glu Asn Phe Met Asn Tyr Ala Lys Lys Asp Leu Thr Ile Leu Phe 
        355                 360                 365             


Gly Ile Met Asp Ala Ser Ser Tyr Glu Lys Lys Ala Glu Ile Ala Arg 
    370                 375                 380                 


Asp Phe Tyr Asp Phe Thr Val Arg Lys Ser Tyr Lys Asn Ile Gly Phe 
385                 390                 395                 400 


Ser Ile Lys Lys Ile Arg Glu Arg Met Met Asp Cys Phe Phe Ala Asn 
                405                 410                 415     


Val Lys Glu Ile Thr Pro Asp Ser Pro Asp Phe Gln Ser Val Arg Gln 
            420                 425                 430         


Lys Phe Tyr Lys Ile Leu Asp Phe Leu Leu Phe Thr Tyr Tyr Lys Asp 
        435                 440                 445             


Asn Lys Glu Glu Thr Lys Lys Ile Ile Ala Ala Leu Arg Ala Ser Leu 
    450                 455                 460                 


Thr Glu Leu Glu Lys Glu Leu Phe Tyr Gln Lys Gln Ala Asn Ile Leu 
465                 470                 475                 480 


Trp Asn Lys Met Gln Met Val Val Thr Glu Gln Ile Tyr Pro Arg Thr 
                485                 490                 495     


Lys Gly Ser Ala Ile Gln Asn Leu Ile Ala Asp Pro Glu Ile Ser Ala 
            500                 505                 510         


Asp Met Leu Lys Gly Val Met Ile Thr Pro Glu Ser Val Asp Tyr Phe 
        515                 520                 525             


Ser Lys Met Ile Tyr Leu Leu Thr Leu Phe Ile Asp Gly Lys Glu Ile 
    530                 535                 540                 


Asn Asp Leu Leu Thr Thr Met Ile Asn Lys Phe Glu Asn Ile Ala Ser 
545                 550                 555                 560 


Phe Val Ser Val Leu Lys Asp Arg Gly Leu Pro Cys Asn Phe Arg Asn 
                565                 570                 575     


Asp Tyr Ser Val Phe Asn Asn Ala Leu Lys Ile Ser Ala Glu Leu Arg 
            580                 585                 590         


Glu Ile Asn Ser Phe Ala Arg Met Glu Lys Ala Thr Pro Gly Ala Lys 
        595                 600                 605             


Lys Gln Met Phe Leu Asp Ala Ala Ile Ile Leu Gly Ser Asn Glu Ser 
    610                 615                 620                 


Ala Glu Glu Leu Ser Glu Tyr Phe Asp Glu Met Leu Asp Lys Gln Lys 
625                 630                 635                 640 


Gly Lys Arg Thr Pro Gly Gly Lys Lys Asp Met Gly Phe Arg Asn Phe 
                645                 650                 655     


Leu Ile Lys Asn Val Ile Glu Ser Asp Arg Phe His Tyr Leu Ile Arg 
            660                 665                 670         


Tyr Gly His Pro Leu His Ile Arg Lys Leu Ala Glu Asn Lys Asn Val 
        675                 680                 685             


Ile Ala Phe Val Leu Lys Gln Ile Pro Glu Pro Gln Ile Asp Arg Tyr 
    690                 695                 700                 


Cys Lys Ile Cys Ala Leu Pro Ala Glu Ser Asn Phe Ala Gln Lys Ile 
705                 710                 715                 720 


Leu Arg Leu Thr Asp Leu Ile Ala Glu Met Asn Phe Arg Gln Phe Glu 
                725                 730                 735     


Asn Val Arg Gln Thr Glu Lys Asn Glu Gln Lys Gln Ile Leu Gln Gly 
            740                 745                 750         


Ile Leu Ser Leu Tyr Leu Thr Val Leu Tyr Leu Leu Thr Lys Asn Leu 
        755                 760                 765             


Val Tyr Val Asn Ser Arg Tyr Phe Leu Ala Phe His Cys Leu Glu Arg 
    770                 775                 780                 


Asp Thr Glu Leu Leu Gly Ser Gln Ala Gly His Lys Asn Ala Glu Lys 
785                 790                 795                 800 


Gln Leu Ile Ala Ser Tyr Ser Ala Leu Thr Gln Gln Phe Leu Asp Glu 
                805                 810                 815     


Gly Lys Leu Asn Arg His Ala Arg Glu Tyr Leu Thr Val Asn Ile Gln 
            820                 825                 830         


Asn Ser Asp Asp Trp Thr Ile Ala Gln Tyr Arg Asn Asn Ala Ala His 
        835                 840                 845             


Leu Asn Ala Ile Arg Asn Ala His Leu Tyr Ile Arg Glu Met Lys Ser 
    850                 855                 860                 


Val Arg Ser Tyr Phe Glu Leu Tyr His Tyr Leu Thr Gln Arg Ala Leu 
865                 870                 875                 880 


Leu Asp Lys Tyr Glu Asn Val Pro Tyr His Pro Gln Val Asn Glu Lys 
                885                 890                 895     


Thr Leu Lys Tyr Phe Glu Leu Leu Lys Glu Asn Gly Trp Tyr Cys Lys 
            900                 905                 910         


Asp Phe Val Lys Ala Leu Asn Val Pro Phe Gly Tyr Asn Leu Pro Arg 
        915                 920                 925             


Tyr Lys Asn Leu Ser Ile Asp Ala Leu Phe Asp Lys Asp Arg Pro Gln 
    930                 935                 940                 


Glu Glu Asp Glu Asn His Leu Tyr Thr Cys Gln Asn Ile Lys Lys Ser 
945                 950                 955                 960 


<210>  3273
<211>  939
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3273

Met Ala Lys Lys Lys Arg Ile Thr Ala Lys Glu Arg Lys Gln Asn His 
1               5                   10                  15      


Arg Glu Ser Leu Met Lys Lys Ala Asp Ser Asn Ala Glu Lys Glu Lys 
            20                  25                  30          


Ala Lys Lys Pro Val Val Glu Asn Lys Pro Asp Thr Ala Ile Ser Lys 
        35                  40                  45              


Asp Asn Thr Pro Lys Pro Asn Lys Glu Ile Lys Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Ala Gly Val Lys Trp Val Ile Lys Ala Asn Asp Asp Val Ala Tyr 
65                  70                  75                  80  


Ile Ser Ser Phe Gly Lys Gly Asn Asn Ser Val Leu Glu Lys Arg Ile 
                85                  90                  95      


Met Gly Asp Val Ser Ser Asn Val Asn Lys Asp Ser His Met Tyr Val 
            100                 105                 110         


Asn Pro Lys Tyr Thr Lys Lys Asn Tyr Glu Ile Lys Asn Gly Phe Ser 
        115                 120                 125             


Ser Gly Ser Ser Leu Val Thr Tyr Pro Asn Lys Pro Asp Lys Asn Ser 
    130                 135                 140                 


Gly Met Asp Ala Leu Cys Leu Lys Pro Tyr Phe Glu Lys Asp Phe Phe 
145                 150                 155                 160 


Gly His Ile Phe Thr Asp Asn Met His Ile Gln Ala Ile Tyr Asn Ile 
                165                 170                 175     


Phe Asp Ile Glu Lys Ile Leu Ala Lys His Ile Thr Asn Ile Ile Tyr 
            180                 185                 190         


Thr Val Asn Ser Phe Asp Arg Asn Tyr Asn Gln Ser Gly Asn Asp Thr 
        195                 200                 205             


Ile Gly Phe Asp Ile Asn Tyr Arg Val Pro Tyr Ser Glu Tyr Gly Gly 
    210                 215                 220                 


Gly Lys Asp Ser Asn Gly Lys Pro Asn Lys Ile Ser Ala Trp Lys Lys 
225                 230                 235                 240 


Arg Glu Asn Phe Ile Lys Phe Tyr Asn Glu Ala Lys Pro His Leu Gly 
                245                 250                 255     


Tyr Tyr Glu Asn Ile Phe Tyr Glu His Gly Glu Pro Ile Ser Glu Glu 
            260                 265                 270         


Lys Phe Tyr Asn Tyr Leu Asn Ile Leu Asn Phe Ile Arg Asn Asn Thr 
        275                 280                 285             


Phe His Tyr Lys Asp Asn Asp Ile Glu Leu Tyr Gly Glu Asn Tyr Ser 
    290                 295                 300                 


Glu Glu Tyr Val Phe Ile Asn Cys Leu Asn Glu Phe Val Lys Asn Lys 
305                 310                 315                 320 


Phe Lys Asn Val Asn Lys Asn Phe Ile Ser Asn Glu Lys Asn Asn Leu 
                325                 330                 335     


Tyr Ile Ile Leu Lys Ala Tyr Gly Glu Asp Thr Glu Asn Val Glu Val 
            340                 345                 350         


Val Lys Lys Tyr Ser Lys Glu Leu Tyr Lys Leu Ser Val Leu Lys Thr 
        355                 360                 365             


Asn Lys Asn Leu Gly Val Asn Val Lys Lys Leu Arg Glu Ser Ala Ile 
    370                 375                 380                 


Glu Tyr Gly Tyr Cys Pro Leu Pro Tyr Asp Lys Glu Lys Glu Val Ala 
385                 390                 395                 400 


Lys Leu Ser Ser Val Lys His Lys Leu Tyr Lys Thr Tyr Asp Phe Val 
                405                 410                 415     


Ile Thr His Tyr Leu Asn Ser Asn Asp Lys Leu Leu Leu Glu Ile Val 
            420                 425                 430         


Glu Thr Leu Arg Leu Ser Lys Asn Asp Asp Glu Lys Glu Asn Val Tyr 
        435                 440                 445             


Lys Lys Tyr Ala Glu Lys Leu Phe Lys Ala Asp Asp Val Ile Asn Pro 
    450                 455                 460                 


Ile Lys Ala Ile Ser Lys Leu Phe Ala Glu Lys Gly Asn Lys Leu Phe 
465                 470                 475                 480 


Lys Glu Lys Ile Ile Ile Lys Lys Glu Tyr Ile Glu Asp Val Ser Ile 
                485                 490                 495     


Asp Lys Asn Ile Tyr Asp Phe Thr Lys Val Ile Phe Phe Met Thr Cys 
            500                 505                 510         


Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Asn Ile Ile Ser 
        515                 520                 525             


Lys Leu Gln Ile Ile Glu Asp His Asn Asn Val Ile Lys Phe Ile Ala 
    530                 535                 540                 


Glu Asn Asp Asp Ala Val Tyr Lys Asp Tyr Ser Asp Lys Tyr Ala Ile 
545                 550                 555                 560 


Phe Arg Asn Ala Gly Lys Ile Ala Thr Glu Leu Glu Ala Ile Lys Ser 
                565                 570                 575     


Ile Ala Arg Met Glu Asn Lys Ile Glu Asn Val Pro Gln Lys Pro Leu 
            580                 585                 590         


Leu Lys Asp Ala Leu Leu Ser Leu Gly Val Ser Asp Asp Thr Lys Val 
        595                 600                 605             


Leu Glu Asn Thr Tyr Asn Lys Tyr Phe Asp Ser Lys Glu Lys Ala Asp 
    610                 615                 620                 


Lys Gln Ser Gln Lys Val Ser Thr Phe Leu Met Asn Asn Val Ile Asn 
625                 630                 635                 640 


Asn Asn Arg Phe Lys Tyr Val Ile Lys Tyr Ile Asn Pro Ala Asp Ile 
                645                 650                 655     


Asn Gly Leu Ala Lys Asn Arg Tyr Leu Val Lys Phe Val Leu Ser Lys 
            660                 665                 670         


Ile Pro Glu Glu Gln Ile Asp Ser Tyr Tyr Lys Leu Phe Ser Asn Glu 
        675                 680                 685             


Glu Glu Pro Ser Cys Glu Glu Lys Ile Lys Leu Leu Thr Lys Lys Ile 
    690                 695                 700                 


Ser Lys Leu Asn Phe Gln Thr Leu Phe Glu Asn Asn Lys Ile Pro Asn 
705                 710                 715                 720 


Val Glu Lys Glu Arg Lys Lys Ala Ile Ile Thr Leu Tyr Phe Thr Ile 
                725                 730                 735     


Val Tyr Ile Leu Val Lys Asn Leu Val Asn Ile Asn Gly Leu Tyr Thr 
            740                 745                 750         


Leu Ala Leu Tyr Phe Val Glu Arg Asp Gly Tyr Phe Tyr Lys Asp Ile 
        755                 760                 765             


Cys Gly Lys Lys Asp Lys Lys Lys Ser Tyr Asn Asp Val Asp Tyr Leu 
    770                 775                 780                 


Leu Leu Ser Glu Ile Phe Ser Gly Ser Lys Tyr Arg Glu Glu Thr Lys 
785                 790                 795                 800 


Asn Leu Lys Leu Pro Lys Glu Lys Asp Arg Asp Ile Met Lys Lys Tyr 
                805                 810                 815     


Leu Pro Asn Asp Lys Asp Arg Glu Lys Tyr Asn Lys Phe Phe Thr Ala 
            820                 825                 830         


Tyr Arg Asn Asn Ile Val His Leu Asn Ile Ile Ala Lys Leu Ser Glu 
        835                 840                 845             


Leu Thr Ser Asn Ile Asp Lys Asp Ile Asn Ser Tyr Phe Asp Ile Tyr 
    850                 855                 860                 


His Tyr Cys Thr Gln Arg Val Met Phe Asp Tyr Cys Lys Lys Asn Asn 
865                 870                 875                 880 


Asn Val Val Leu Ala Lys Met Lys Asp Leu Ala His Ile Lys Ser Asp 
                885                 890                 895     


Cys Asp Glu Phe Ser Ser Lys His Thr Tyr Pro Phe Ser Ser Ala Val 
            900                 905                 910         


Leu Arg Phe Met Asn Leu Pro Phe Ala Tyr Asn Val Pro Arg Phe Lys 
        915                 920                 925             


Asn Leu Ser Tyr Lys Lys Phe Phe Asp Lys Gln 
    930                 935                 


<210>  3274
<211>  946
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3274

Met Lys Lys Phe Ser Asn Ile Lys Arg Leu Gly Val Lys Ser Val His 
1               5                   10                  15      


Tyr Ala Asn Asn Thr Val Ile Val Glu Asp His Phe Ser Lys Asn Thr 
            20                  25                  30          


Asn Ile Leu Phe Thr Ala Glu Tyr Glu Asn Ile Asp Asp Leu Lys Ser 
        35                  40                  45              


Cys Thr Asn Ile Asp Lys Thr Ala Glu Asn Lys Gly Val Arg Phe Thr 
    50                  55                  60                  


Asp Leu Lys Asn Lys Asn Gly Phe Glu Leu Ser Ala Met Ala Gln Lys 
65                  70                  75                  80  


Gln Ile Leu Lys Ser Arg Val Asn Arg Val Lys Lys Val Ser Tyr Thr 
                85                  90                  95      


Gln Glu Leu Phe Asp Ile Thr Thr Asp Asn Asn Ile Glu Val Gln Ile 
            100                 105                 110         


Phe Ser Asn Leu Glu Asp Val Lys Lys Val Ile Ala Pro Tyr Tyr Asn 
        115                 120                 125             


Asn Val Ala Tyr Ala Ile Asn Ser Leu Tyr Arg Asp Ile Ser Asn Asp 
    130                 135                 140                 


Asp Ser Tyr Gly Phe Asp Lys Ile Gly Ser Ile Pro Val Asp Ala Asp 
145                 150                 155                 160 


Trp Tyr Asn Phe Leu Lys Asp Ala Pro Asp Lys Lys Glu Lys Trp Thr 
                165                 170                 175     


Thr Tyr Ile Ile Pro Ser Tyr Lys Lys Val Ile Ala Arg Phe Gly Ile 
            180                 185                 190         


Gln Met Glu Lys Asn Gln Gln Val Asn Phe Cys Lys Cys Leu Glu Tyr 
        195                 200                 205             


Val Ala Ile Arg Asn Gly Leu Phe Val Lys Phe Lys Asp Glu Lys Val 
    210                 215                 220                 


Asp Pro Asp Lys Leu Leu Asn Lys Lys Ile Gln Glu Lys Leu Asp Lys 
225                 230                 235                 240 


Leu Ile Ser Asp Lys Glu Val Asn Asp Lys Leu Phe Glu Leu Ala Lys 
                245                 250                 255     


Thr Pro Val Ser Glu Phe Cys Ala Glu Ala Asn Ala Ile Pro Leu Tyr 
            260                 265                 270         


Arg Tyr Ala Phe Ile Gly Gln Lys Gly Lys Arg Ile Glu Lys Ile Val 
        275                 280                 285             


Leu Asp Lys Leu Glu Glu Asn Glu Ile Leu Ser Ser Leu Val Arg Lys 
    290                 295                 300                 


Ile Asp Glu Asn Glu Thr Thr Tyr Asn Tyr Leu Arg Leu Leu Ser Ala 
305                 310                 315                 320 


Ile Arg Gln Tyr Val Val His Asn Ser Arg Lys Val Arg Ile Asp Lys 
                325                 330                 335     


Asn Val Phe Ile Asn Asp Thr Ala Lys Arg Asp Val Glu Glu Phe Ala 
            340                 345                 350         


Lys Gln Phe Gln Lys Asn Asn Tyr Lys Tyr Phe Cys Ile Leu Lys Glu 
        355                 360                 365             


Leu Tyr Ser Asp Ser Asp Ile Leu Glu Gln Phe Phe Asp Tyr Thr Val 
    370                 375                 380                 


Phe Asp Glu Ala Arg Asn Leu Lys Ile Ser Ile Asp Lys Ile Lys Lys 
385                 390                 395                 400 


Gly Ile Thr Ala Asn Ile Asp Ile Ser Ala Asp Val Glu Pro Asp Lys 
                405                 410                 415     


Leu Ser Glu Tyr Ala Asn Lys Phe Arg Thr Val Thr Met Phe Ala Leu 
            420                 425                 430         


Thr Lys Tyr Leu Lys Glu Asn Val Gly Glu Ile Glu Asp Phe Leu Ala 
        435                 440                 445             


Asn Ile Lys Val Cys Ser Ser Asp Glu Glu Lys Ala Gly Val Tyr Glu 
    450                 455                 460                 


Gln Lys Ala Lys Glu Phe Ile Thr Lys Phe Asp Ser Phe Lys Asp Ile 
465                 470                 475                 480 


Arg Ser Val Val Lys Lys His Leu Gly Thr Gln Lys Val Asn Glu Lys 
                485                 490                 495     


Phe Asp Phe Tyr Pro Ser Asp Ile Asn Phe Gly Arg Asp Ser Asn Val 
            500                 505                 510         


Phe Phe Asn Met Leu Tyr Val Met Ser Lys Phe Leu Thr Val Asn Glu 
        515                 520                 525             


Ala Arg Ile Met Phe Gln Lys Ile Lys Ser Lys Tyr Asp Ser Val Lys 
    530                 535                 540                 


Ser Leu Leu Lys Ile Ala Glu Leu Thr Gly Val Thr Leu Ser Asp Asn 
545                 550                 555                 560 


Leu Phe Asp Arg Phe Arg Met Ile Phe Asp Lys Glu Arg Val Asp Glu 
                565                 570                 575     


Tyr Gln Lys Gln Leu Ile Val Leu Gln Ser Ile Arg Thr Arg Asn Gly 
            580                 585                 590         


Val Ser Gln Glu Gly Phe Ala Lys Glu Leu Lys Arg Ile Phe Asp Met 
        595                 600                 605             


Phe Lys Lys Asp Asp Ile Ser Tyr Glu Glu Phe Glu Lys Glu Leu Ser 
    610                 615                 620                 


Leu Asp Glu Asn Gln Asn Glu Ile Lys Asn Lys Ser Phe Lys Leu Lys 
625                 630                 635                 640 


Pro Leu Lys Ser Tyr Leu Arg Asn Asp Val Tyr Lys Ser Lys Gln Tyr 
                645                 650                 655     


Gln Tyr Ile Ser Ser Phe Ala Ser Ala Gly Ile Cys Gln Lys Ile Met 
            660                 665                 670         


Glu Asn Lys Asp Ile Val Ala Phe Val Leu Asn Gly Met Leu Tyr Gln 
        675                 680                 685             


Glu Gly Lys Leu Ser Met Pro Met His Lys Tyr Val Ala Lys Val Tyr 
    690                 695                 700                 


His Asp Phe Arg Arg Glu Lys Ile Asp Glu Asn Ser Ala Asn Tyr Leu 
705                 710                 715                 720 


Leu Asp Gln Asn Gln Ile Ser Ser Leu Val Asn Ser Leu Cys Asp Leu 
                725                 730                 735     


Lys Leu Glu Asn Ile Ile Glu Ala Ile Phe Lys Glu Ser Arg Val Asn 
            740                 745                 750         


Tyr Lys Ala Leu Val Arg Leu Tyr Leu Asn Ile Cys Tyr Leu Phe Val 
        755                 760                 765             


Lys Asn Ile Ile Ser Leu Asn Ser Thr Tyr Leu Ile Gln Phe Gln Asp 
    770                 775                 780                 


Tyr Glu Asn Ile Tyr Lys Gln Leu His Leu Glu Asp Leu Met Asp Ile 
785                 790                 795                 800 


Thr Tyr Asp Phe Gly Val Leu Asn Asn Phe Val Glu Asn Ala Pro Asn 
                805                 810                 815     


Lys Lys Cys Arg Ser Tyr Met Gln Leu Gln Thr Leu Leu Glu Lys Asp 
            820                 825                 830         


Tyr Ile Lys Asp Tyr Ile Tyr Thr Pro Glu Tyr Gln Val Leu Gln Asp 
        835                 840                 845             


Arg Tyr Arg Asn Leu Val Val His Ser Ser Leu Leu Phe Gly Leu Asp 
    850                 855                 860                 


Lys Ile Asp Phe Asp Phe Gly Glu Val Gln Asn Ile Ser Ser Tyr Phe 
865                 870                 875                 880 


Ala Ile Tyr Gln Thr Leu Val Gln Arg Leu Val Glu Gln Asp Ala Arg 
                885                 890                 895     


Glu Val Trp Gly Glu Lys Phe Asp Glu Tyr Phe Ala Leu Asn Asn Gly 
            900                 905                 910         


Lys Thr Tyr Ser Thr Lys Leu Cys Ile Ala Leu Asn Met Pro Tyr Ala 
        915                 920                 925             


Tyr Asn Ile Ser Arg Phe Asn Asn Asn Thr Ile Glu Lys Tyr Ser Asn 
    930                 935                 940                 


Lys Arg 
945     


<210>  3275
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3275

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Ile Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Pro Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn His Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3276
<211>  927
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3276

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Thr Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asp Tyr Asn 
                85                  90                  95      


Gln Thr Gln Leu Ser Ser Lys Asp Ser Ser Asn Ile Glu Leu His Gly 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Leu Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Ser Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Asp Ser Asn 
        195                 200                 205             


Tyr Asp Phe Met Gly Tyr Leu Ser Thr Phe Asn Thr Tyr Lys Val Phe 
    210                 215                 220                 


Thr Asn Pro Asn Gly Ser Thr Leu Ser Asp Asp Lys Lys Lys Asn Ile 
225                 230                 235                 240 


Arg Lys Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu 
                245                 250                 255     


Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Asn Ala Leu 
            260                 265                 270         


Glu Ala Tyr Lys Lys Arg Val Tyr Tyr Met Leu Ala Ile Val Gly Gln 
        275                 280                 285             


Ile Arg Gln Cys Val Phe His Asp Leu Thr Asp His Ser Glu Tyr Asp 
    290                 295                 300                 


Leu Tyr Ser Phe Ile Tyr Asn Ser Lys Lys Val Tyr Lys Glu Cys Arg 
305                 310                 315                 320 


Glu Thr Leu Asp Tyr Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys 
                325                 330                 335     


Gly Phe Ile Glu Gly Asn Lys Ile Asn Ile Ser Leu Leu Ile Asp Met 
            340                 345                 350         


Met Lys Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe 
        355                 360                 365             


Ile Val Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu 
    370                 375                 380                 


Arg Glu Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln 
385                 390                 395                 400 


Tyr Asp Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu 
                405                 410                 415     


Phe Cys Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val 
            420                 425                 430         


Arg Lys Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr 
        435                 440                 445             


Ala Asp Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu 
    450                 455                 460                 


Asn Ile Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys 
465                 470                 475                 480 


Ala Asp Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn 
                485                 490                 495     


Ala Ser Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr 
            500                 505                 510         


Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser 
        515                 520                 525             


Lys Phe Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala 
    530                 535                 540                 


Val Asp Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp 
545                 550                 555                 560 


Ser Gln Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser 
                565                 570                 575     


Met Arg Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala 
            580                 585                 590         


Leu Thr Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser 
        595                 600                 605             


Glu Ile Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg 
    610                 615                 620                 


Asn Phe Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu 
625                 630                 635                 640 


Ile Lys Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu 
                645                 650                 655     


Lys Val Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu 
            660                 665                 670         


Arg Tyr Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu 
        675                 680                 685             


Glu Ala Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe 
    690                 695                 700                 


Asp Asp Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val 
705                 710                 715                 720 


Ala Lys Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met 
                725                 730                 735     


Tyr Leu Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile 
            740                 745                 750         


Ala Ile His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile 
        755                 760                 765             


Pro Glu Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser 
    770                 775                 780                 


Gln Thr Leu Cys Glu Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu 
785                 790                 795                 800 


Phe Leu Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile 
                805                 810                 815     


Asn Asn Ala Asp Ser Ile Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala 
            820                 825                 830         


His Leu Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg 
        835                 840                 845             


Thr Val Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys 
    850                 855                 860                 


Ile Thr Lys Arg Glu Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr 
865                 870                 875                 880 


Glu Asp Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys 
                885                 890                 895     


Ala Leu Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu 
            900                 905                 910         


Ser Ile Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925         


<210>  3277
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3277

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Val Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asn Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Gln Asn Thr Tyr Tyr Ile Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu Tyr Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Glu Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Val Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Arg Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Lys Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3278
<211>  939
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3278

Met Ala Lys Lys Lys Arg Ile Thr Ala Lys Glu Arg Lys Gln Asn His 
1               5                   10                  15      


Arg Glu Ser Leu Met Lys Lys Ala Asp Ser Asn Ala Glu Lys Glu Lys 
            20                  25                  30          


Ala Lys Lys Pro Val Val Glu Asn Lys Pro Asp Thr Ala Ile Ser Lys 
        35                  40                  45              


Asp Asn Thr Pro Lys Pro Asn Lys Glu Ile Lys Lys Ser Lys Ala Lys 
    50                  55                  60                  


Leu Ala Gly Val Lys Trp Val Ile Lys Ala Asn Asp Asp Val Ala Tyr 
65                  70                  75                  80  


Ile Ser Ser Phe Gly Lys Gly Asn Asn Ser Val Leu Glu Lys Arg Ile 
                85                  90                  95      


Met Gly Asp Val Ser Ser Asn Val Asn Lys Asp Ser His Met Tyr Val 
            100                 105                 110         


Asn Pro Lys Tyr Thr Lys Lys Asn Tyr Glu Ile Lys Asn Gly Phe Ser 
        115                 120                 125             


Ser Gly Ser Ser Leu Val Thr Tyr Pro Asn Lys Pro Asp Lys Asn Ser 
    130                 135                 140                 


Gly Met Asp Ala Leu Cys Leu Lys Pro Tyr Phe Glu Lys Asp Phe Phe 
145                 150                 155                 160 


Gly His Ile Phe Thr Asp Asn Met His Ile Gln Ala Ile Tyr Asn Ile 
                165                 170                 175     


Phe Asp Ile Glu Lys Ile Leu Ala Lys His Ile Thr Asn Ile Ile Tyr 
            180                 185                 190         


Thr Val Asn Ser Phe Asp Arg Asn Tyr Asn Gln Ser Gly Asn Asp Thr 
        195                 200                 205             


Ile Gly Phe Asp Ile Asn Tyr Arg Val Pro Tyr Ser Glu Tyr Gly Gly 
    210                 215                 220                 


Gly Lys Asp Ser Asn Gly Lys Pro Asn Lys Ile Ser Ala Trp Lys Lys 
225                 230                 235                 240 


Arg Glu Asn Phe Ile Lys Phe Tyr Asn Glu Ala Lys Pro His Leu Gly 
                245                 250                 255     


Tyr Tyr Glu Asn Ile Phe Tyr Glu His Gly Glu Pro Ile Ser Glu Glu 
            260                 265                 270         


Lys Phe Tyr Asn Tyr Leu Asn Ile Leu Asn Phe Ile Arg Asn Asn Thr 
        275                 280                 285             


Phe His Tyr Lys Asp Asn Asp Ile Glu Leu Tyr Gly Glu Asn Tyr Ser 
    290                 295                 300                 


Glu Glu Tyr Val Phe Ile Asn Cys Leu Asn Glu Phe Val Lys Asn Lys 
305                 310                 315                 320 


Phe Lys Asn Val Asn Lys Asn Phe Ile Ser Asn Glu Lys Asn Asn Leu 
                325                 330                 335     


Tyr Ile Ile Leu Lys Ala Tyr Gly Glu Asp Thr Glu Asn Val Glu Val 
            340                 345                 350         


Val Lys Lys Tyr Ser Lys Glu Leu Tyr Lys Leu Ser Val Leu Lys Thr 
        355                 360                 365             


Asn Lys Asn Leu Gly Val Asn Val Lys Lys Leu Arg Glu Ser Ala Ile 
    370                 375                 380                 


Glu Tyr Gly Tyr Cys Pro Leu Pro Tyr Asp Lys Glu Lys Glu Val Ala 
385                 390                 395                 400 


Lys Leu Ser Ser Val Lys His Lys Leu Tyr Lys Thr Tyr Asp Phe Val 
                405                 410                 415     


Ile Thr His Tyr Leu Asn Ser Asn Asp Lys Leu Leu Leu Glu Ile Val 
            420                 425                 430         


Glu Thr Leu Arg Leu Ser Lys Asn Asp Asp Glu Lys Glu Asn Val Tyr 
        435                 440                 445             


Lys Lys Tyr Ala Glu Lys Leu Phe Lys Ala Asp Asp Val Ile Asn Pro 
    450                 455                 460                 


Ile Lys Ala Ile Ser Lys Leu Phe Ala Glu Lys Gly Asn Lys Leu Phe 
465                 470                 475                 480 


Lys Glu Lys Ile Ile Ile Lys Lys Glu Tyr Ile Glu Asp Val Ser Ile 
                485                 490                 495     


Asp Lys Asn Ile Tyr Asp Phe Thr Lys Val Ile Phe Phe Met Thr Cys 
            500                 505                 510         


Phe Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Asn Ile Ile Ser 
        515                 520                 525             


Lys Leu Gln Ile Ile Glu Asp His Asn Asn Val Ile Lys Phe Ile Ala 
    530                 535                 540                 


Glu Asn Asp Asp Ala Val Tyr Lys Asp Tyr Ser Asp Lys Tyr Ala Ile 
545                 550                 555                 560 


Phe Arg Asn Ala Gly Lys Ile Ala Thr Glu Leu Glu Ala Ile Lys Ser 
                565                 570                 575     


Ile Ala Arg Met Glu Asn Lys Ile Glu Asn Val Pro Gln Lys Pro Leu 
            580                 585                 590         


Leu Lys Asp Ala Leu Leu Ser Leu Gly Val Ser Asp Asp Thr Lys Val 
        595                 600                 605             


Leu Glu Asn Thr Tyr Asn Lys Tyr Phe Asp Ser Lys Glu Lys Ala Asp 
    610                 615                 620                 


Lys Gln Ser Gln Lys Val Ser Thr Phe Leu Met Asn Asn Val Ile Asn 
625                 630                 635                 640 


Asn Asn Arg Phe Lys Tyr Val Ile Lys Tyr Ile Asn Pro Ala Asp Ile 
                645                 650                 655     


Asn Gly Leu Ala Lys Asn Arg Tyr Leu Val Lys Phe Val Leu Ser Lys 
            660                 665                 670         


Ile Pro Glu Glu Gln Ile Asp Ser Tyr Tyr Lys Leu Phe Ser Asn Glu 
        675                 680                 685             


Glu Glu Pro Ser Cys Glu Glu Lys Ile Lys Leu Leu Thr Lys Lys Ile 
    690                 695                 700                 


Ser Lys Leu Asn Phe Gln Thr Leu Phe Glu Asn Asn Lys Ile Pro Asn 
705                 710                 715                 720 


Val Glu Lys Glu Arg Lys Lys Ala Ile Ile Thr Leu Tyr Phe Thr Ile 
                725                 730                 735     


Val Tyr Ile Leu Val Lys Asn Leu Val Asn Ile Asn Gly Leu Tyr Thr 
            740                 745                 750         


Leu Ala Leu Tyr Phe Val Glu Arg Asp Gly Tyr Phe Tyr Lys Asp Ile 
        755                 760                 765             


Cys Gly Lys Lys Asp Lys Lys Lys Ser Tyr Asn Asp Val Asp Tyr Leu 
    770                 775                 780                 


Leu Leu Ser Glu Ile Phe Ser Gly Ser Lys Tyr Arg Glu Glu Thr Lys 
785                 790                 795                 800 


Asn Leu Lys Leu Pro Lys Glu Lys Asp Arg Asp Ile Met Lys Lys Tyr 
                805                 810                 815     


Leu Pro Asn Asp Lys Asp Arg Glu Lys Tyr Asn Lys Phe Phe Thr Ala 
            820                 825                 830         


Tyr Arg Asn Asn Ile Val His Leu Asn Ile Ile Ala Lys Leu Ser Glu 
        835                 840                 845             


Leu Thr Ser Asn Ile Asp Lys Asp Ile Asn Ser Tyr Phe Asp Ile Tyr 
    850                 855                 860                 


His Tyr Cys Thr Gln Arg Val Met Phe Asp Tyr Cys Lys Lys Asn Asn 
865                 870                 875                 880 


Asn Val Val Leu Ala Lys Met Lys Asp Leu Ala His Ile Lys Ser Asp 
                885                 890                 895     


Cys Asp Glu Phe Ser Ser Lys His Thr Tyr Pro Phe Ser Ser Ala Val 
            900                 905                 910         


Leu Arg Phe Met Asn Leu Pro Phe Ala Tyr Asn Val Pro Arg Phe Lys 
        915                 920                 925             


Asn Leu Ser Tyr Lys Lys Phe Phe Asp Lys Gln 
    930                 935                 


<210>  3279
<211>  923
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3279

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Val Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Glu Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asn Ser Ser Asn Ile Glu Leu Arg Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Gly Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu His Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Asp Asp Tyr 
            340                 345                 350         


Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys 
        355                 360                 365             


Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met 
    370                 375                 380                 


Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val 
385                 390                 395                 400 


Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr 
                405                 410                 415     


Tyr Arg Asn Asp Val Ile Ala Gly Glu Ala Leu Val Arg Lys Leu Arg 
            420                 425                 430         


Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala 
        435                 440                 445             


Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp 
    450                 455                 460                 


His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp 
465                 470                 475                 480 


Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu 
                485                 490                 495     


Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly 
            500                 505                 510         


Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn 
        515                 520                 525             


Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu 
    530                 535                 540                 


Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile 
545                 550                 555                 560 


Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro 
                565                 570                 575     


Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu 
            580                 585                 590         


Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys 
        595                 600                 605             


Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr 
    610                 615                 620                 


Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala 
625                 630                 635                 640 


Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met 
                645                 650                 655     


Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys 
            660                 665                 670         


Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg 
        675                 680                 685             


Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys 
    690                 695                 700                 


Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg 
705                 710                 715                 720 


Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val 
                725                 730                 735     


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys 
            740                 745                 750         


Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala 
        755                 760                 765             


Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys 
    770                 775                 780                 


Glu Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys 
785                 790                 795                 800 


Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp 
                805                 810                 815     


Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val 
            820                 825                 830         


Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser 
        835                 840                 845             


Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg 
    850                 855                 860                 


Glu Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu 
865                 870                 875                 880 


Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser 
                885                 890                 895     


Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln 
            900                 905                 910         


Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920             


<210>  3280
<211>  1023
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3280

Met Ala Lys Lys Ile Thr Ala Lys Gln Lys Arg Glu Glu Lys Glu Arg 
1               5                   10                  15      


Leu Asn Lys Gln Lys Trp Ala Lys Gln Asp Thr Pro Val Val Pro Lys 
            20                  25                  30          


Ser Lys Thr Glu Glu Lys Pro Val Ala Ala Ser Asp Asp Lys Leu Leu 
        35                  40                  45              


Lys Thr Thr Gln Val Lys Lys Val Gln Thr Lys Ser Lys Ala Lys Ala 
    50                  55                  60                  


Met Gly Leu Lys Thr Val Leu Ser Phe Asp Asp Lys Ile Ala Ile Ala 
65                  70                  75                  80  


Ser Phe Val Asn Asp Lys Lys Thr Lys Leu Pro His Ile Glu Arg Ile 
                85                  90                  95      


Thr Asp Lys Ser Gly Thr Thr Ile His Glu Asn Ala Arg Met Phe Asp 
            100                 105                 110         


Ser Ser Val Asp Glu Gln Asn Val Asn Ile Glu Lys Arg Met Thr Ile 
        115                 120                 125             


Glu Glu Lys Gln Asn Asp Gly Thr Phe Lys Lys Asp Glu Lys Asp Val 
    130                 135                 140                 


Lys Ala Thr Ile Cys Asn Pro Tyr Phe Lys Thr Cys Gly Lys Asp Tyr 
145                 150                 155                 160 


Ile Gly Ile Lys Asp Val Ala Glu Lys Tyr Phe Phe Gly Lys Thr Phe 
                165                 170                 175     


Pro Asn Glu Asn Leu Arg Val Gln Ile Ala Tyr Asn Val Phe Asp Ile 
            180                 185                 190         


Gln Lys Ile Leu Gly Thr Tyr Val Asn Asn Ile Ile Tyr Ser Phe Tyr 
        195                 200                 205             


Asn Leu Arg Arg Asp Gly Lys Ser Asp Val Asp Ile Ile Gly Ser Leu 
    210                 215                 220                 


Tyr Ala Phe Ala Asp Phe Asp Asn Gln Leu Lys Asp Lys Pro Ala Phe 
225                 230                 235                 240 


Arg Glu Ala Lys Asp Leu Leu Lys Asn Thr Glu Ala Tyr Phe Ser Tyr 
                245                 250                 255     


Phe Gly Asp Val Phe Lys Lys Ser Lys Lys Gly Lys Lys Asp Glu Asn 
            260                 265                 270         


Asn Glu Asp Tyr Glu Lys Asn Leu Arg His Asn Phe Asn Val Leu Arg 
        275                 280                 285             


Val Leu Ser Phe Leu Arg Gln Ile Cys Thr His Ala Tyr Val Lys Cys 
    290                 295                 300                 


Thr Ser Gly Ala Lys Asn Asn Gly Asp Ser Thr Lys Val Val Ala Glu 
305                 310                 315                 320 


Ser Leu Asp Ala Leu Phe Asn Ile Thr Glu Tyr Phe Asp Lys Thr Ala 
                325                 330                 335     


Pro Glu Leu Ser Lys Thr Ile Asn Glu Ile Tyr Lys Glu Gly Val Asp 
            340                 345                 350         


Arg Ile Asn Asn Asp Phe Val Thr Asn Gly Lys Asn Asn Leu Tyr Ile 
        355                 360                 365             


Leu Ser Lys Val Tyr Pro Asp Met Gln Arg Asn Glu Leu Val Lys Lys 
    370                 375                 380                 


Tyr Tyr Gln Phe Val Val Cys Lys Glu Gly Asn Asn Val Gly Ile Asn 
385                 390                 395                 400 


Thr Arg Lys Leu Lys Glu Ser Ile Ile Ser Gln Asn Pro Trp Ile Thr 
                405                 410                 415     


Thr Pro Gln Asp Asn Asn Lys Ala Asn Asp Tyr Lys Ser Cys Gln His 
            420                 425                 430         


Lys Leu Tyr Thr Ile Met Cys Phe Ile Leu Val Ala Glu Leu Asp Ala 
        435                 440                 445             


His Glu Ser Ile Arg Asp Asn Met Val Ala Glu Leu Arg Ala Asn Met 
    450                 455                 460                 


Asp Gly Asp Asp Gly Arg Asp Ala Ile Tyr Glu Lys Tyr Ala Lys Asp 
465                 470                 475                 480 


Ile Tyr His Ile Val Lys Asp Lys Leu Leu Ala Met Gln Lys Val Phe 
                485                 490                 495     


Asp Glu Glu Leu Val Pro Val Lys Val Glu Glu Glu Asn Asp Pro Gln 
            500                 505                 510         


Arg Phe Thr His Gly Lys Leu Gly Lys Lys Glu Ile Glu Ser Phe Cys 
        515                 520                 525             


Leu Ser Asp Lys Asn Thr Ser Asp Ile Ala Lys Val Val Tyr Phe Leu 
    530                 535                 540                 


Cys Asn Phe Leu Asp Gly Lys Glu Ile Asn Glu Leu Cys Cys Ala Met 
545                 550                 555                 560 


Met Asn Lys Phe Asp Gly Ile Gly Asp Leu Ile Asp Thr Ala Lys Gln 
                565                 570                 575     


Cys Gly Glu Glu Val Lys Phe Ile Glu Lys Phe Ala Cys Leu Ser Asn 
            580                 585                 590         


Cys Arg Lys Ile Thr Asp Asp Ile Arg Val Ala Lys Ser Ile Ser Lys 
        595                 600                 605             


Met Lys Asn Lys Val Lys Ile Asp Asn Asp Ile Ile Tyr Leu Asp Ala 
    610                 615                 620                 


Ile Glu Leu Leu Gly Arg Lys Ile Glu Lys Tyr Gln Lys Asp Glu Ser 
625                 630                 635                 640 


Gly Lys Ile Leu Leu Gly Thr Asp Gly Lys Arg Leu Tyr Thr Lys Glu 
                645                 650                 655     


Tyr Lys Tyr Phe Asn Asp Met Phe Phe Asn Ala Gly Asn His Lys Val 
            660                 665                 670         


Arg Lys Phe Ile Asn Asn Asn Val Met Lys Ser Lys Trp Phe Phe Tyr 
        675                 680                 685             


Val Val Arg Tyr Asn Lys Pro Ala Glu Cys Gln Ile Ile Met Arg Asn 
    690                 695                 700                 


Lys Thr Leu Val Lys Phe Thr Leu Asp Asp Leu Pro Asp Glu Gln Ile 
705                 710                 715                 720 


Gln Arg Tyr Tyr Ser Ser Val Phe Gly Asp Asn Asn Met Pro Thr Val 
                725                 730                 735     


Asp Val Met Arg Glu Trp Leu Leu Lys Lys Ile Asn Gln Phe Ser Val 
            740                 745                 750         


Arg Gly Phe Leu Asp Asp Ile Asp Glu Glu Ser Lys Gln Asn Lys Ser 
        755                 760                 765             


Ser Glu Thr Glu Gln Lys Lys Ser Leu Ile Arg Leu Tyr Leu Thr Ile 
    770                 775                 780                 


Ala Tyr Leu Ile Thr Lys Ser Met Val Lys Ile Asn Thr Arg Phe Ser 
785                 790                 795                 800 


Ile Ala Cys Ala Thr Tyr Glu Arg Asp Tyr Ala Leu Leu Cys Gln Ser 
                805                 810                 815     


Gln Gln Lys Gly Gly Pro Trp Asp Gly Gly Ala Gln Ala Leu Ala Val 
            820                 825                 830         


Thr Arg Lys Phe Leu Asn His Asp Arg Glu Ile Phe Asp Arg Tyr Cys 
        835                 840                 845             


Ala Arg Glu Ala Glu Ile Ala Arg Leu Pro Ser Glu Glu Arg Lys Pro 
    850                 855                 860                 


Leu Arg Lys Ala Asn Asp Lys Leu Leu Lys Gln Thr His Tyr Thr Asn 
865                 870                 875                 880 


His Ser Tyr Thr Tyr Ile Val Asn Asn Leu Asn Ser Phe Thr Asp Ile 
                885                 890                 895     


Asp Tyr Cys Ala Lys Asp Val Gly Leu Pro Ala Pro Asn Asp Lys Asn 
            900                 905                 910         


Asp Asn Ala Ser Ile Leu Gly Glu Met Arg Asn Asp Ile Ala His Leu 
        915                 920                 925             


Asn Val Val His Asp Met Val Lys Tyr Ile Glu Glu Leu Lys Asp Ile 
    930                 935                 940                 


Ser Ser Tyr Tyr Ala Phe Tyr Cys Tyr Val Leu Gln Arg Arg Leu Val 
945                 950                 955                 960 


Gly Asn Asp Pro Asn Cys Gln Asn Lys Phe Lys Ala Lys Tyr Ala Lys 
                965                 970                 975     


Glu Leu Asn Tyr Tyr Gly Thr Tyr Asn Lys Asn Leu Met Trp Met Leu 
            980                 985                 990         


Asn Leu Pro Phe Ala Tyr Asn Leu  Pro Arg Tyr Lys Asn  Leu Ser Ser 
        995                 1000                 1005             


Glu Phe  Leu Phe Tyr Asp Met  Glu Tyr Asn Lys Lys  Asp Asp Glu 
    1010                 1015                 1020             


<210>  3281
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3281

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Arg Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Asn Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn Ile Lys Lys 
225                 230                 235                 240 


Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu His Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Pro Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Thr Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ser 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ser Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Lys Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  3282
<211>  956
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3282

Met Gly Lys Lys Ile His Ala Arg Asp Leu Arg Glu Gln Arg Lys Thr 
1               5                   10                  15      


Asp Arg Thr Glu Lys Phe Ala Asp Gln Asn Lys Lys Arg Glu Ala Glu 
            20                  25                  30          


Arg Ala Val Pro Lys Lys Asp Ala Ala Val Ser Val Lys Ser Val Ser 
        35                  40                  45              


Ser Val Ser Ser Lys Lys Asp Asn Val Thr Lys Ser Met Ala Lys Ala 
    50                  55                  60                  


Ala Gly Val Lys Ser Val Phe Ala Val Gly Asn Thr Val Tyr Met Thr 
65                  70                  75                  80  


Ser Phe Gly Arg Gly Asn Asp Ala Val Leu Glu Gln Lys Ile Val Asp 
                85                  90                  95      


Thr Ser His Glu Pro Leu Asn Ile Asp Asp Pro Ala Tyr Gln Leu Asn 
            100                 105                 110         


Val Val Thr Met Asn Gly Tyr Ser Val Thr Gly His Arg Gly Glu Thr 
        115                 120                 125             


Val Ser Ala Val Thr Asp Asn Pro Leu Arg Arg Phe Asn Gly Arg Lys 
    130                 135                 140                 


Lys Asp Glu Pro Glu Gln Ser Val Pro Thr Asp Met Leu Cys Leu Lys 
145                 150                 155                 160 


Pro Thr Leu Glu Lys Lys Phe Phe Gly Lys Glu Phe Asp Asp Asn Ile 
                165                 170                 175     


His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala 
            180                 185                 190         


Val Tyr Ser Thr Asn Ala Ile Tyr Ala Leu Asn Asn Met Ser Ala Asp 
        195                 200                 205             


Glu Asn Ile Glu Asn Ser Asp Phe Phe Met Lys Arg Thr Thr Asp Glu 
    210                 215                 220                 


Thr Phe Asp Asp Phe Glu Lys Lys Lys Glu Ser Thr Asn Ser Arg Glu 
225                 230                 235                 240 


Lys Ala Asp Phe Asp Ala Phe Glu Lys Phe Ile Gly Asn Tyr Arg Leu 
                245                 250                 255     


Ala Tyr Phe Ala Asp Ala Phe Tyr Val Asn Lys Lys Asn Pro Lys Gly 
            260                 265                 270         


Lys Ala Lys Asn Val Leu Arg Glu Asp Lys Glu Leu Tyr Ser Val Leu 
        275                 280                 285             


Thr Leu Ile Gly Lys Leu Arg His Trp Cys Val His Ser Glu Glu Gly 
    290                 295                 300                 


Arg Ala Glu Phe Trp Leu Tyr Lys Leu Asp Glu Leu Lys Asp Asp Phe 
305                 310                 315                 320 


Lys Asn Val Leu Asp Val Val Tyr Asn Arg Pro Val Glu Glu Ile Asn 
                325                 330                 335     


Asn Arg Phe Ile Glu Asn Asn Lys Val Asn Ile Gln Ile Leu Gly Ser 
            340                 345                 350         


Val Tyr Lys Asn Thr Asp Ile Ala Glu Leu Val Arg Ser Tyr Tyr Glu 
        355                 360                 365             


Phe Leu Ile Thr Lys Lys Tyr Lys Asn Met Gly Phe Ser Ile Lys Lys 
    370                 375                 380                 


Leu Arg Glu Ser Met Leu Glu Gly Lys Gly Tyr Ala Asp Lys Glu Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Asn Lys Leu Tyr Gln Met Thr Asp Phe Ile Leu Tyr 
                405                 410                 415     


Thr Gly Tyr Ile Asn Glu Asp Ser Asp Arg Ala Asp Asp Leu Val Asn 
            420                 425                 430         


Thr Leu Arg Ser Ser Leu Lys Glu Asp Asp Lys Thr Thr Val Tyr Cys 
        435                 440                 445             


Lys Glu Ala Asp Tyr Leu Trp Lys Lys Tyr Arg Glu Ser Ile Arg Glu 
    450                 455                 460                 


Val Ala Asp Ala Leu Asp Val Asp Asn Ile Lys Asn Leu Ser Gly Ser 
465                 470                 475                 480 


Asn Ile Glu Ile Arg Asp Asn Glu Leu Arg Lys Cys Phe Ile Ser Tyr 
                485                 490                 495     


Ala Asp Ser Val Ser Glu Phe Thr Lys Leu Ile Tyr Leu Leu Thr Arg 
            500                 505                 510         


Phe Leu Ser Gly Lys Glu Ile Asn Asp Leu Val Thr Thr Leu Ile Asn 
        515                 520                 525             


Lys Phe Asp Asn Ile Arg Ser Phe Leu Glu Ile Met Asp Glu Leu Gly 
    530                 535                 540                 


Leu Asp Arg Thr Phe Thr Ala Glu Tyr Ser Phe Phe Glu Gly Ser Thr 
545                 550                 555                 560 


Lys Tyr Leu Ala Glu Leu Val Glu Leu Asn Ser Phe Val Lys Ser Cys 
                565                 570                 575     


Ser Phe Asp Ile Asn Ala Lys Arg Thr Met Tyr Arg Asp Ala Leu Asp 
            580                 585                 590         


Ile Leu Gly Ile Glu Ser Asp Lys Thr Glu Glu Asp Ile Glu Lys Met 
        595                 600                 605             


Ile Asp Asn Ile Leu Gln Ile Asp Ala Asn Gly Asp Lys Lys Leu Lys 
    610                 615                 620                 


Lys Asn Asn Gly Leu Arg Asn Phe Ile Ala Ser Asn Val Ile Asp Ser 
625                 630                 635                 640 


Asn Arg Phe Lys Tyr Leu Val Arg Tyr Gly Asn Pro Lys Lys Ile Arg 
                645                 650                 655     


Glu Thr Ala Lys Cys Glu Pro Ala Val Arg Phe Val Leu Asn Glu Ile 
            660                 665                 670         


Pro Asp Ala Gln Ile Glu Arg Tyr Tyr Glu Ala Cys Cys Pro Lys Asn 
        675                 680                 685             


Thr Ala Leu Cys Ser Ala Asn Lys Arg Arg Glu Lys Leu Ala Asp Met 
    690                 695                 700                 


Ile Ala Glu Ile Lys Phe Glu Asn Phe Ser Asp Ala Gly Ser Tyr Gln 
705                 710                 715                 720 


Lys Ala Asn Ala Thr Ser Thr Arg Ile Thr Ser Glu Ala Glu Ile Lys 
                725                 730                 735     


Arg Lys Asn Gln Ala Ile Ile Arg Leu Tyr Leu Thr Val Met Tyr Ile 
            740                 745                 750         


Met Leu Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Phe 
        755                 760                 765             


His Cys Val Glu Arg Asp Thr Lys Leu Tyr Ala Glu Ser Gly Leu Glu 
    770                 775                 780                 


Val Gly Asn Ile Glu Lys Asn Lys Thr Asn Leu Thr Met Ala Val Met 
785                 790                 795                 800 


Gly Val Lys Leu Glu Asn Gly Ile Ile Lys Thr Glu Phe Asp Lys Ser 
                805                 810                 815     


Leu Ala Glu Asn Ala Ala Asn Arg Tyr Leu Arg Asn Ala Arg Trp Tyr 
            820                 825                 830         


Lys Leu Ile Leu Asp Asn Leu Lys Lys Ser Glu Arg Ala Val Val Asn 
        835                 840                 845             


Glu Phe Arg Asn Thr Val Cys His Leu Asn Ala Ile Arg Asn Ile Asn 
    850                 855                 860                 


Ile Asn Ile Asp Gly Ile Lys Glu Val Glu Asn Tyr Phe Ala Leu Tyr 
865                 870                 875                 880 


His Tyr Leu Ile Gln Lys His Leu Glu Asn Arg Phe Ala Asp Lys Lys 
                885                 890                 895     


Val Glu Arg Asp Thr Gly Asp Phe Ile Ser Lys Leu Glu Glu His Lys 
            900                 905                 910         


Thr Tyr Cys Lys Asp Phe Val Lys Ala Tyr Cys Thr Pro Phe Gly Tyr 
        915                 920                 925             


Asn Leu Val Arg Tyr Lys Asn Leu Thr Ile Asp Gly Leu Phe Asp Lys 
    930                 935                 940                 


Asn Tyr Pro Gly Lys Asp Asp Ser Asp Glu Gln Lys 
945                 950                 955     


<210>  3283
<211>  984
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3283

Met Lys Lys Lys Asn Ile Arg Ala Thr Arg Glu Ala Leu Lys Ala Gln 
1               5                   10                  15      


Lys Ile Lys Lys Ser Gln Glu Asn Glu Ala Leu Lys Lys Gln Lys Leu 
            20                  25                  30          


Ala Glu Glu Ala Ala Gln Lys Arg Arg Glu Glu Leu Glu Lys Lys Asn 
        35                  40                  45              


Leu Ala Gln Trp Glu Glu Thr Ser Ala Glu Gly Arg Arg Ser Arg Val 
    50                  55                  60                  


Lys Ala Val Gly Val Lys Ser Val Phe Val Val Gly Asp Asp Leu Tyr 
65                  70                  75                  80  


Leu Ala Thr Phe Gly Asn Gly Asn Glu Thr Val Leu Glu Lys Lys Ile 
                85                  90                  95      


Thr Pro Asp Gly Lys Ile Thr Thr Phe Pro Glu Glu Glu Thr Phe Thr 
            100                 105                 110         


Ala Lys Leu Lys Phe Ala Lys Thr Glu Leu Thr Glu Ala Thr Ser Ile 
        115                 120                 125             


Gly Ile Ser Asn Gly Arg Ile Val Leu Pro Glu Ile Ser Val Asp Asn 
    130                 135                 140                 


Pro Leu His Thr Thr Met Gln Lys Asn Thr Ile Lys Lys Ser Ala Gly 
145                 150                 155                 160 


Glu Asp Met Leu Gln Leu Lys Asp Val Leu Glu Asn Arg Tyr Phe Asp 
                165                 170                 175     


Arg Ser Phe Asn Asn Asp Leu His Ile Arg Leu Ile Tyr Asn Ile Leu 
            180                 185                 190         


Asp Ile Glu Lys Ile Leu Ala Glu Tyr Thr Thr Asn Ala Val Phe Ala 
        195                 200                 205             


Ile Asp Asn Val Ser Gly Cys Ser Asp Asp Phe Leu Ser Asn Phe Ser 
    210                 215                 220                 


Thr Arg Asn Gln Trp Asp Glu Phe Gln Asn Pro Glu Gln His Arg Glu 
225                 230                 235                 240 


His Phe Gly Asn Lys Asp Asn Val Ile Cys Ser Val Lys Lys Gln Gln 
                245                 250                 255     


Asp Leu Phe Phe Asn Phe Phe Lys Asn Asn Arg Ile Gly Tyr Phe Gly 
            260                 265                 270         


Lys Ala Phe Phe His Ala Glu Ser Glu Arg Lys Ile Val Lys Lys Thr 
        275                 280                 285             


Ala Lys Glu Val Tyr His Ile Leu Thr Leu Ile Gly Ser Leu Arg Gln 
    290                 295                 300                 


Trp Ile Thr His Ser Thr Glu Gly Gly Ile Ser Arg Leu Trp Leu Tyr 
305                 310                 315                 320 


Gln Leu Glu Asp Ala Leu Ser Ser Glu Tyr Gln Glu Thr Met Asn Asn 
                325                 330                 335     


Cys Tyr Asn Ser Thr Ile Tyr Gly Leu Gln Lys Asp Phe Glu Lys Thr 
            340                 345                 350         


Asn Ala Pro Asn Leu Asn Phe Leu Ala Glu Ile Leu Gly Lys Asn Ala 
        355                 360                 365             


Ser Glu Leu Ala Glu Pro Tyr Phe Arg Phe Ile Ile Thr Lys Glu Tyr 
    370                 375                 380                 


Lys Asn Leu Gly Phe Ser Ile Lys Thr Leu Arg Glu Met Leu Leu Asp 
385                 390                 395                 400 


Gln Pro Asp Leu Gln Glu Ile Arg Glu Asn His Asn Val Tyr Asp Ser 
                405                 410                 415     


Ile Arg Ser Lys Leu Tyr Lys Met Met Asp Phe Val Leu Val Tyr Ala 
            420                 425                 430         


Tyr Ser Asn Glu Arg Lys Ser Lys Ala Asp Ala Leu Ala Ser Asn Leu 
        435                 440                 445             


Arg Ser Ala Ile Thr Glu Asp Ala Lys Lys Arg Val Tyr Gln Asn Glu 
    450                 455                 460                 


Ala Asp Gln Leu Trp Thr Ser Tyr Gln Glu Leu Phe Lys Arg Ile Arg 
465                 470                 475                 480 


Gly Phe Lys Gly Ala Gln Val Lys Glu Tyr Ser Ser Gln Asn Met Pro 
                485                 490                 495     


Ile Pro Ile Gln Lys Gln Ile Gln Asn Ile Leu Lys Pro Ala Glu Gln 
            500                 505                 510         


Val Thr Cys Phe Thr Lys Leu Met Tyr Leu Leu Thr Met Phe Leu Asp 
        515                 520                 525             


Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp 
    530                 535                 540                 


Asn Ile Ser Ser Leu Leu Lys Thr Met Glu Gln Leu Glu Leu Gln Thr 
545                 550                 555                 560 


Thr Phe Lys Glu Asp Tyr Thr Phe Phe Gln Gln Ser Ser Cys Leu Cys 
                565                 570                 575     


Glu Glu Ile Thr Gln Leu Lys Ser Phe Ala Arg Met Gly Asn Pro Ile 
            580                 585                 590         


Ser Asn Leu Lys Glu Val Met Met Val Asp Ala Ile Gln Ile Leu Gly 
        595                 600                 605             


Thr Glu Lys Ser Glu Gln Glu Leu Gln Ser Met Ala Cys Phe Phe Phe 
    610                 615                 620                 


Arg Asp Lys Asn Gly Lys Lys Leu Asn Ala Gly Glu His Gly Met Arg 
625                 630                 635                 640 


Asn Phe Ile Gly Asn Asn Val Ile Ser Asn Thr Arg Phe Gln Tyr Leu 
                645                 650                 655     


Ile Arg Tyr Gly Asn Pro Gln Lys Leu His Thr Leu Ser Gln Asn Glu 
            660                 665                 670         


Thr Val Val Arg Phe Val Leu Ser Arg Ile Ala Lys Asn Gln Arg Val 
        675                 680                 685             


Gln Gly Met Asn Gly Lys Asn Gln Ile Asp Arg Tyr Tyr Glu Thr Cys 
    690                 695                 700                 


Gly Gly Thr Asn Ser Trp Ser Val Ser Glu Glu Glu Lys Ile Asn Phe 
705                 710                 715                 720 


Leu Cys Lys Ile Leu Thr Asn Met Ser Tyr Asp Gln Phe Gln Asp Val 
                725                 730                 735     


Lys Gln Ser Asp Lys Ile Ile Thr Ala Glu Glu Lys Arg Lys Lys Glu 
            740                 745                 750         


Arg Tyr Lys Ala Ile Ile Ser Leu Tyr Leu Thr Val Leu Tyr Gln Leu 
        755                 760                 765             


Ile Lys Asn Leu Val Asn Ile Asn Ala Arg Tyr Ile Ile Ala Phe His 
    770                 775                 780                 


Cys Leu Glu Arg Asp Ala Ile Leu Tyr Ser Leu Lys Phe Asn Thr Ser 
785                 790                 795                 800 


Ile Asn Leu Lys Lys Arg Tyr Thr Ala Leu Thr Glu Met Ile Leu Gly 
                805                 810                 815     


Tyr Glu Thr Asp Glu Lys Ala Arg Arg Lys Asp Thr Arg Thr Ile Tyr 
            820                 825                 830         


Glu Lys Ala Glu Ala Ala Lys Asn Arg His Leu Lys Asn Val Lys Trp 
        835                 840                 845             


Asn Cys Lys Thr Arg Glu Asn Leu Glu Asn Ala Asp Lys Asn Ala Ile 
    850                 855                 860                 


Val Ala Phe Arg Asn Ile Val Ala His Leu Trp Ile Ile Arg Asp Ala 
865                 870                 875                 880 


Asp Arg Phe Ile Thr Glu Met Gly Ala Met Lys Arg Tyr Phe Asp Cys 
                885                 890                 895     


Tyr His Tyr Leu Leu Gln Arg Glu Leu Glu Tyr Ile Leu Glu Lys Ser 
            900                 905                 910         


Asn Gln Gly Ser Lys Tyr Thr Lys Lys Ser Leu Glu Lys Val Gln Gln 
        915                 920                 925             


Tyr His Ser Tyr Cys Lys Asp Phe Leu His Met Leu Cys Leu Pro Phe 
    930                 935                 940                 


Ala Tyr Cys Ile Pro Arg Tyr Lys Asn Leu Ser Ile Ala Glu Leu Phe 
945                 950                 955                 960 


Asp Arg His Glu Leu Glu Ala Glu Pro Lys Glu Glu Ala Ser Pro Ala 
                965                 970                 975     


Asn Asn Ser Gln Phe Ile Thr Thr 
            980                 


<210>  3284
<211>  923
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3284

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asp Asn Asp Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asn 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Arg Arg Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Ser Val Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Gln Asn Thr Tyr Tyr Ile 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val 
            260                 265                 270         


Ser Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu 
    290                 295                 300                 


Tyr Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Asp Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Asp Asp Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile 
        355                 360                 365             


Val Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg 
    370                 375                 380                 


Glu Lys Met Leu Glu Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Ser Lys Met Tyr Lys Ile Met Asp Phe Leu Leu Phe 
                405                 410                 415     


Cys Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg 
            420                 425                 430         


Lys Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala 
        435                 440                 445             


Asp Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn 
    450                 455                 460                 


Ile Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala 
465                 470                 475                 480 


Asp Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala 
                485                 490                 495     


Ser Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe 
            500                 505                 510         


Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys 
        515                 520                 525             


Phe Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val 
    530                 535                 540                 


Asp Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser 
545                 550                 555                 560 


Gln Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met 
                565                 570                 575     


Arg Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu 
            580                 585                 590         


Ala Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu 
        595                 600                 605             


Ile Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn 
    610                 615                 620                 


Phe Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile 
625                 630                 635                 640 


Lys Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys 
                645                 650                 655     


Val Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg 
            660                 665                 670         


Tyr Tyr Lys Ser Cys Val Glu Val Pro Asp Met Asn Ser Ser Leu Glu 
        675                 680                 685             


Ala Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp 
    690                 695                 700                 


Asp Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala 
705                 710                 715                 720 


Lys Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr 
                725                 730                 735     


Leu Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala 
            740                 745                 750         


Ile His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro 
        755                 760                 765             


Glu Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln 
    770                 775                 780                 


Thr Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys 
785                 790                 795                 800 


Asn Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp 
                805                 810                 815     


Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val 
            820                 825                 830         


Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser 
        835                 840                 845             


Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg 
    850                 855                 860                 


Glu Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu 
865                 870                 875                 880 


Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser 
                885                 890                 895     


Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln 
            900                 905                 910         


Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920             


<210>  3285
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3285

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Phe 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Val Tyr Asn 
                85                  90                  95      


Gln Thr Gln Leu Ser Ser Glu Asp Ser Ser Asn Ile Glu Leu Cys Gly 
            100                 105                 110         


Val Thr Lys Val Asn Ile Thr Phe Ser Ser Lys His Gly Leu Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Ser Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Phe Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ser Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser 
        195                 200                 205             


His Asp Asp Phe Ile Gly Tyr Leu Ser Thr Asn Asn Ile Tyr Asp Val 
    210                 215                 220                 


Phe Ile Asp Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn 
225                 230                 235                 240 


Val Arg Lys Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Cys Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Ile Ile Asp Pro Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Pro Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Lys Val Ala Glu Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Glu Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3286
<211>  999
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3286

Met Lys Lys Lys Arg Leu Asn Ala Gln Ala Lys Lys Glu Thr Lys Asn 
1               5                   10                  15      


Ala Leu Asn Lys Gln Lys Gly Gln Gln Tyr Leu Lys Pro Lys Ala Ser 
            20                  25                  30          


Glu Ala Leu Gln Leu Asn Ala Val Lys Glu Ile Lys Asn Asp Glu Ile 
        35                  40                  45              


Ser Lys Gln Asp Lys Lys Ser Thr Ala Lys Lys Met Gly Leu Lys Ser 
    50                  55                  60                  


Thr Leu Val Thr Cys Asp Lys Val Val Val Thr Ser Phe Val Asn Lys 
65                  70                  75                  80  


Lys Gly Thr Asn Gly Ser Asn Ile Glu Lys Val Thr Ser His Lys Gly 
                85                  90                  95      


Glu Lys Ile Ala Glu Gly Leu Tyr Thr Glu Arg Met Phe Lys Thr Asp 
            100                 105                 110         


Val Thr Glu Asp Glu Ile Cys Ile Ser Lys Gln Glu His Asn Ser Thr 
        115                 120                 125             


Phe Ile Asn Pro Ala Lys Lys Asp Ile Gly Arg Asp Tyr Leu Gly Val 
    130                 135                 140                 


Lys Glu Ile Leu Glu Asn Lys Tyr Phe Ser Gly Pro Lys Ser Asp Asn 
145                 150                 155                 160 


Val His Val Gln Ile Gly Tyr Asn Ile Met Asp Ile Arg Lys Ile Ile 
                165                 170                 175     


Thr Ala Tyr Val Asn Asn Ile Val Ser Leu Phe Tyr Asn Leu Asn Arg 
            180                 185                 190         


Ser Ala Lys Glu Asp Gln Arg Asp Ile Ile Gly Thr Leu Gly Glu Phe 
        195                 200                 205             


Tyr Asn Leu Asp Ser Gln Glu Asn Lys Ala Leu Glu Asp Leu Lys Thr 
    210                 215                 220                 


Lys Glu Lys Leu Asp Gln Ile Lys Glu Ile Phe Asn Lys Gly Ala Ile 
225                 230                 235                 240 


Lys Tyr Tyr Phe Lys Asp Ile Phe Lys Ile Val Pro Ser Leu Ser Lys 
                245                 250                 255     


Asp Asp Lys Glu Asn Pro Glu Lys Leu Ala Lys Tyr Glu Glu Glu Lys 
            260                 265                 270         


Arg Lys Val Glu Asp Tyr Asn Phe Asn Val Leu Arg Val Leu Thr Met 
        275                 280                 285             


Met Arg Asn Leu Cys Tyr His Ser Lys Asn Arg Ala Gly Thr Gly Gly 
    290                 295                 300                 


Asp Ile Gly Leu Leu Asn Leu Glu Arg Val Val Gly Ala Thr Asn Asn 
305                 310                 315                 320 


Ser Asn Thr Gln Asp Asn Lys Glu Leu Leu Glu Leu Ile Gln Asn Val 
                325                 330                 335     


Cys Val Ser Ser Ile Ser Lys Ile Asn Glu Asn Phe Val Ser Asn Ser 
            340                 345                 350         


Gly Asn Asn Val Tyr Val Leu Ser Gln Leu Tyr Pro Gly Glu Asp Val 
        355                 360                 365             


Leu Lys Gln Tyr Tyr Ser Tyr Val Val Glu Lys Glu Asn Arg Asn Ile 
    370                 375                 380                 


Gly Val Asn Leu Thr Lys Ile Arg Glu Val Ile Phe Asp Val Tyr Leu 
385                 390                 395                 400 


Thr Glu Leu Lys Asp Lys Glu Tyr Asp Thr Tyr Arg Asn Lys Ile Tyr 
                405                 410                 415     


Thr Ile Leu Gly Phe Ile Leu Tyr Lys Glu Leu Thr Ser Ser Ser Ile 
            420                 425                 430         


Leu Asp Lys Met Ile Glu Glu Leu Arg Phe Gly Glu Lys Asn Glu Val 
        435                 440                 445             


Leu Arg Asp Ser Val Tyr Glu Thr Tyr Ala Lys Lys Ile Tyr Ile Asp 
    450                 455                 460                 


Leu Lys Leu Lys Glu Lys Tyr Glu Asn Ala Ile Lys Glu Leu Lys Lys 
465                 470                 475                 480 


Glu Lys Glu Asn Lys Phe Glu Ser Lys Lys Glu Ile Ala Leu Lys Asp 
                485                 490                 495     


Ile Lys Glu Tyr Ala Ile Asn Ala Asn Gly Ile Ser Cys Phe Val Gln 
            500                 505                 510         


Ser Met Leu Phe Leu Thr Lys Phe Leu Asp Gly Lys Glu Thr Asn Glu 
        515                 520                 525             


Leu Ile Cys Ala Leu Ile Asn Lys Phe Asp Asn Ile Ala Asp Ile Leu 
    530                 535                 540                 


Glu Val Ala Lys Gln Ile Gly Leu Glu Val Glu Phe Ala Ser Asp Tyr 
545                 550                 555                 560 


Ile Ser Leu Asn Asp Ser Arg Lys Ile Ser Lys Asp Leu Arg Leu Ile 
                565                 570                 575     


Lys Asn Ile Ala His Leu Lys Asp Lys Lys Thr Lys Thr Lys Asn Asp 
            580                 585                 590         


Glu Lys Ala Asn Asp Gln Glu Asp Lys Ile Pro Phe Val Met Leu Leu 
        595                 600                 605             


Asp Ala Tyr Asn Met Leu Asn Val Lys Ala Asp Ser Gln Ile Val Tyr 
    610                 615                 620                 


Gly Ser Lys Glu Ala Asn Glu Leu Tyr Asn Leu Ile Tyr Lys Thr Gln 
625                 630                 635                 640 


Lys Lys Gly Thr Asp Lys Asn Ser Thr Gln Lys Tyr Asn Tyr Gln Phe 
                645                 650                 655     


Lys Asn Phe Ile Glu Asn Asn Val Ile Lys Ser Lys Trp Phe Leu Tyr 
            660                 665                 670         


Ile Ala Lys Tyr Val Asp Pro Ala Asn Cys Ala Thr Phe Met Ala Asn 
        675                 680                 685             


Glu Ala Ile Leu Asn Phe Val Val Lys Glu Leu Pro Pro Lys Gln Ile 
    690                 695                 700                 


Leu Arg Tyr Tyr Gln Thr Ile Thr Gly Ser Glu Val Glu Val Ser Glu 
705                 710                 715                 720 


Asp Gln Met Arg Lys Ser Ile Ile Tyr Asn Leu Lys Arg Phe Ser Val 
                725                 730                 735     


Lys Asp Ser Leu Thr Ala Ile Ser Asp Met Ser Glu Glu Glu Tyr Lys 
            740                 745                 750         


Pro Lys Thr Lys Asp Ile Thr Ser Ser Ile Glu Lys Gln Lys Ala Ile 
        755                 760                 765             


Val Ser Leu Tyr Leu Thr Val Ala Phe Leu Ile Val Lys Ser Met Val 
    770                 775                 780                 


Lys Val Asn Thr Arg Phe Ser Ile Ala Phe Asn Cys Leu Glu Arg Asp 
785                 790                 795                 800 


Leu Val Leu Lys Gly His Asn Phe Lys Asn Tyr Asp Lys Leu Thr Thr 
                805                 810                 815     


Thr Tyr Leu Lys Ala Asp Lys Glu Ile Ile Asp Asp Thr Ala Ala Glu 
            820                 825                 830         


Ile Glu Lys Ile Tyr Leu Asp Phe Lys Asn Ala Thr Asp Ala Thr Ala 
        835                 840                 845             


Lys Glu Gln Ala Arg Lys Leu Leu Asn Lys Thr Leu Lys Ala Arg Asp 
    850                 855                 860                 


Lys Lys Met His Phe Ser Tyr Lys Lys Tyr Lys Glu Ile Ser Ser Asn 
865                 870                 875                 880 


Leu Glu Asn Ala Ile Lys Asn Lys Ile Asn Phe Thr Ala Phe Arg Asn 
                885                 890                 895     


Ala Ile Glu His Leu Asn Val Ile Lys Ala Met Pro Asn Tyr Phe Lys 
            900                 905                 910         


Glu Val Lys Asn Val Gln Ser Tyr Tyr Ala Leu Phe Cys Tyr Ile Leu 
        915                 920                 925             


Gln Arg Leu Leu Ile Glu Glu Gly Ala Ile Asp Asn Gln Val Leu Ala 
    930                 935                 940                 


Asp Lys Ile Val Ala Glu Gly Gly Tyr Ser Lys Arg Val Gln Asn Leu 
945                 950                 955                 960 


Met Trp Gln Leu Asn Leu Pro Phe Ala Tyr Asn Leu Pro Arg Tyr Lys 
                965                 970                 975     


Asn Leu Ser Met Glu Ser Leu Phe Tyr Ser Lys Asp Asn Met Ser Asn 
            980                 985                 990         


Leu Asp Lys Lys Asp Asn Val 
        995                 


<210>  3287
<211>  933
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3287

Met Glu Arg Gln Lys Arg Lys Met Lys Ser Lys Ser Lys Met Ala Gly 
1               5                   10                  15      


Val Lys Ser Val Phe Val Ile Gly Asp Glu Leu Leu Met Thr Ser Phe 
            20                  25                  30          


Gly Asp Gly Asp Asp Ala Val Leu Glu Lys Asp Ile Asp Glu Asn Gly 
        35                  40                  45              


Val Val Asn Asp Cys Arg Asn Pro Ala Ala Tyr Asp Ala Val Tyr Gly 
    50                  55                  60                  


Thr Asp Ser Ile Arg Val Lys Lys Thr Asn Asn Asn Ile Arg Ala Lys 
65                  70                  75                  80  


Val Asn Asn Pro Leu Ala Lys Ser Asn Ile Arg Ser Glu Glu Ser Ala 
                85                  90                  95      


Leu Phe Arg Thr Arg Val Asn Glu Tyr Lys Arg Glu Gln Lys Asp Lys 
            100                 105                 110         


Tyr Glu Thr Leu Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile 
        115                 120                 125             


Gln Leu Ile Ser Lys Ile Leu Asp Ile Glu Lys Thr Phe Ser Val Val 
    130                 135                 140                 


Ile Gly Asn Ile Val Tyr Ala Ile Asn Asn Leu Ser Leu Glu Gln Ser 
145                 150                 155                 160 


Ile Asp Arg Pro Ile Asp Ile Phe Gly Asp Lys Asn Thr Gln Gly Ile 
                165                 170                 175     


Ser Leu Arg Glu Asp Asn Asp Tyr Leu Lys Thr Met Leu Pro Arg Cys 
            180                 185                 190         


Glu Tyr Leu Phe His Asn Ile Leu Asn Ser Asp Ser Asp Asn Asn Ser 
        195                 200                 205             


Lys Met Asn Tyr Asn Lys Val Asn Lys Gly Lys Glu Glu Lys Asp Asn 
    210                 215                 220                 


Arg Asn Asn Glu Asn Ile Glu Lys Leu Lys Lys Ala Leu Glu Val Ile 
225                 230                 235                 240 


Lys Ile Ile Arg Val Asp Ser Phe His Gly Val Asp Gly Ile Lys Gly 
                245                 250                 255     


Asp Gln Lys Phe Pro Arg Ser Lys Tyr Asn Leu Ala Val Asn Tyr Asn 
            260                 265                 270         


Glu Glu Ile Gln Lys Thr Ile Ser Glu Pro Phe Asn Arg Lys Val Glu 
        275                 280                 285             


Glu Val Gln Gln Asp Phe Tyr Arg Asn Ser Cys Val Asn Ile Asp Phe 
    290                 295                 300                 


Leu Lys Glu Ile Met Tyr Gly Ser Asn Tyr Thr Asp Arg Gly Ser Asp 
305                 310                 315                 320 


Ser Leu Glu Cys Ser Tyr Phe Asn Phe Ala Ile Leu Lys Gln Asn Lys 
                325                 330                 335     


Asn Met Gly Phe Ser Ile Thr Ser Ile Arg Glu Cys Leu Leu Asp Leu 
            340                 345                 350         


Tyr Glu Leu Asn Phe Glu Ser Met Gln Asn Leu Arg Pro Arg Ala Asn 
        355                 360                 365             


Ser Phe Cys Asp Phe Leu Ile Tyr Asp Tyr Tyr Cys Lys Asn Glu Ser 
    370                 375                 380                 


Glu Arg Ala Asn Leu Val Asp Cys Leu Arg Ser Ala Ala Ser Glu Glu 
385                 390                 395                 400 


Glu Lys Lys Asn Ile Tyr Phe Gln Thr Ala Glu Arg Val Lys Glu Lys 
                405                 410                 415     


Phe Arg Asn Ala Phe Asn Arg Ile Ser Arg Phe Asp Ala Ser Tyr Ile 
            420                 425                 430         


Lys Asn Ser Arg Glu Lys Asn Leu Ser Gly Gly Ser Ser Leu Pro Lys 
        435                 440                 445             


Tyr Ser Phe Ile Glu Gly Phe Thr Lys Arg Ser Lys Lys Ile Asn Asp 
    450                 455                 460                 


Asn Asp Glu Lys Asn Ala Asp Leu Phe Cys Asn Met Leu Tyr Tyr Leu 
465                 470                 475                 480 


Ala Gln Phe Leu Asp Gly Lys Glu Ile Asn Ile Phe Leu Thr Ser Ile 
                485                 490                 495     


His Asn Ile Phe Gln Asn Ile Asp Ser Phe Leu Lys Val Met Lys Glu 
            500                 505                 510         


Lys Gly Met Glu Cys Lys Phe Gln Lys Asp Phe Asn Met Phe Ser His 
        515                 520                 525             


Ala Gly Tyr Val Ala Lys Lys Ile Glu Ile Val Ile Ser Leu Ala Lys 
    530                 535                 540                 


Met Lys Lys Thr Leu Asp Phe Tyr Asn Ala Gln Ala Leu Lys Asp Ala 
545                 550                 555                 560 


Val Thr Ile Leu Gly Val Ser Lys Lys His Gln Tyr Leu Asp Met Asn 
                565                 570                 575     


Ser Tyr Leu Asp Phe Tyr Met Phe Asp Asn Arg Ser Gly Ala Thr Gly 
            580                 585                 590         


Lys Asn Ala Gly Lys Asp His Asn Leu Arg Asn Phe Leu Val Ser Asn 
        595                 600                 605             


Val Ile Arg Ser Arg Lys Phe Asn Tyr Leu Ser Arg Tyr Ser Asn Leu 
    610                 615                 620                 


Ala Glu Val Lys Lys Leu Ala Gln Asn Pro Ser Leu Val Gln Phe Val 
625                 630                 635                 640 


Leu Ser Arg Ile Glu Pro Ser Leu Ile Cys Arg Tyr Tyr Glu Ser Ser 
                645                 650                 655     


Gln Gly Ile Ser Ser Glu Gly Ile Thr Ile Asp Glu Gln Ile Lys Lys 
            660                 665                 670         


Leu Thr Gly Ile Ile Val Asp Met Asn Ile Asp Ser Phe Glu Asn Ile 
        675                 680                 685             


Asn Asn Gly Glu Ile Gly Met Arg Tyr Ser Lys Ala Thr Pro Gln Ser 
    690                 695                 700                 


Ile Glu Arg Arg Asn Gln Met Arg Val Cys Val Gly Leu Tyr Leu Asn 
705                 710                 715                 720 


Val Leu Tyr Gln Ile Glu Lys Asn Leu Met Asn Val Asn Ala Arg Tyr 
                725                 730                 735     


Val Leu Ala Phe Ala Phe Ala Glu Arg Asp Ala Leu Met Leu Asn Phe 
            740                 745                 750         


Thr Leu Glu Glu Cys Lys Lys Asn Lys Lys Arg Ser Ser Gly Gly Phe 
        755                 760                 765             


Ser Phe Ile Glu Met Thr Gln Phe Phe Ile Asp Lys Lys Leu Phe Lys 
    770                 775                 780                 


Val Ala Thr Glu Ala Ile Lys Lys Asn Val Leu Lys Tyr Asn Gly Asn 
785                 790                 795                 800 


Pro Glu Ser Leu Asn His Ile Pro Gly Glu Tyr Ile Cys Lys Asn Met 
                805                 810                 815     


Glu Gly Tyr His Glu Asn Thr Val Arg Asn Phe Arg Asn Met Val Ala 
            820                 825                 830         


His Leu Thr Ala Val Ala Arg Val Pro Leu Tyr Ile Ser Glu Val Thr 
        835                 840                 845             


Gln Ile Asp Ser Tyr Tyr Ala Leu Tyr His Tyr Cys Met Gln Met Asn 
    850                 855                 860                 


Ile Leu Gln Gly Ile Glu Gln Ser Gly Lys Ile Leu Asp Asn Ile Lys 
865                 870                 875                 880 


Leu Lys Asn Ala Leu Glu Asn Ala Arg Val His Arg Thr Tyr Ser Lys 
                885                 890                 895     


Asp Ala Val Lys Tyr Leu Cys Leu Pro Phe Ala Tyr Asn Ile Ser Arg 
            900                 905                 910         


Tyr Lys Ala Leu Thr Ile Lys Asp Leu Phe Asp Trp Thr Glu Tyr Ser 
        915                 920                 925             


Cys Lys Lys Asp Glu 
    930             


<210>  3288
<211>  984
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3288

Met Lys Lys Lys Asn Ile Arg Ala Thr Arg Glu Ala Leu Lys Ala Gln 
1               5                   10                  15      


Lys Ile Lys Lys Ser Gln Glu Asn Glu Ala Leu Lys Lys Gln Lys Leu 
            20                  25                  30          


Ala Glu Glu Ala Ala Gln Lys Arg Arg Glu Glu Leu Glu Lys Lys Asn 
        35                  40                  45              


Leu Ala Gln Trp Glu Glu Thr Ser Ala Glu Gly Arg Arg Ser Arg Val 
    50                  55                  60                  


Lys Ala Val Gly Val Lys Ser Val Phe Val Val Gly Asp Asp Leu Tyr 
65                  70                  75                  80  


Leu Ala Thr Phe Gly Asn Gly Asn Glu Thr Val Leu Glu Lys Lys Ile 
                85                  90                  95      


Ala Pro Asp Gly Lys Ile Thr Thr Phe Pro Glu Glu Glu Thr Phe Thr 
            100                 105                 110         


Ala Lys Leu Lys Phe Ala Gln Thr Glu Pro Thr Glu Ala Thr Ser Ile 
        115                 120                 125             


Gly Ile Ser Asn Gly Arg Ile Val Leu Pro Glu Ile Ser Val Asp Asn 
    130                 135                 140                 


Pro Leu His Thr Thr Met Gln Lys Asn Thr Ile Lys Arg Ser Ala Gly 
145                 150                 155                 160 


Glu Asp Met Leu Gln Leu Lys Asn Val Leu Glu Asn Arg Tyr Phe Asp 
                165                 170                 175     


Arg Ser Phe Asn Asp Asp Leu His Ile Arg Leu Ile Tyr Asn Ile Leu 
            180                 185                 190         


Asp Ile Glu Lys Ile Leu Ala Glu Tyr Thr Thr Asn Ala Val Phe Ala 
        195                 200                 205             


Ile Asp Asn Val Ser Gly Cys Ser Asp Asp Phe Leu Ser Asn Phe Ser 
    210                 215                 220                 


Thr Arg Asn Gln Trp Asp Glu Phe Gln Asn Pro Glu Gln His Arg Glu 
225                 230                 235                 240 


His Phe Gly Asn Lys Asp Asn Val Ile Cys Ser Val Lys Lys Gln Gln 
                245                 250                 255     


Asp Leu Phe Phe Asn Phe Phe Lys Asn Asn Arg Ile Gly Tyr Phe Gly 
            260                 265                 270         


Lys Ala Phe Phe His Ala Glu Ser Glu Arg Lys Ile Val Lys Lys Thr 
        275                 280                 285             


Ala Lys Glu Val Tyr His Ile Leu Thr Leu Ile Gly Ser Leu Arg Gln 
    290                 295                 300                 


Trp Ile Thr His Ser Thr Glu Gly Gly Ile Ser Arg Leu Trp Leu Tyr 
305                 310                 315                 320 


Gln Leu Glu Asp Ala Leu Ser Ser Glu Tyr Gln Glu Thr Met Asn Asn 
                325                 330                 335     


Cys Tyr Asn Ser Thr Ile Tyr Gly Leu Gln Lys Asp Phe Glu Lys Thr 
            340                 345                 350         


Asn Ala Pro Asn Leu Asn Phe Leu Ala Glu Ile Leu Gly Lys Asn Ala 
        355                 360                 365             


Ser Glu Leu Ala Glu Pro Tyr Phe Arg Phe Ile Ile Thr Lys Glu Tyr 
    370                 375                 380                 


Lys Asn Leu Gly Phe Ser Ile Lys Thr Leu Arg Glu Met Leu Leu Asp 
385                 390                 395                 400 


Gln Pro Asp Leu Gln Glu Ile Arg Glu Asn His Asn Val Tyr Asp Ser 
                405                 410                 415     


Ile Arg Ser Lys Leu Tyr Lys Met Met Asp Phe Val Leu Val Tyr Ala 
            420                 425                 430         


Tyr Ser Asn Glu Arg Lys Ser Lys Ala Asp Ala Leu Ala Ser Asn Leu 
        435                 440                 445             


Arg Ser Ala Ile Thr Glu Asp Ala Lys Lys Arg Ile Tyr Gln Asn Glu 
    450                 455                 460                 


Ala Asp Gln Leu Trp Thr Ser Tyr Gln Glu Leu Phe Lys Arg Ile Arg 
465                 470                 475                 480 


Gly Phe Lys Gly Ala Gln Val Lys Glu Tyr Ser Ser Gln Asn Ile Pro 
                485                 490                 495     


Ile Pro Ile Gln Lys Gln Ile Gln Asn Ile Leu Lys Pro Ala Glu Gln 
            500                 505                 510         


Val Thr Cys Phe Thr Lys Leu Met Tyr Leu Leu Thr Met Phe Leu Asp 
        515                 520                 525             


Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Asn Lys Phe Asp 
    530                 535                 540                 


Asn Ile Ser Ser Leu Leu Lys Thr Met Glu Gln Leu Glu Leu Gln Thr 
545                 550                 555                 560 


Thr Phe Lys Glu Asp Tyr Thr Phe Phe Gln Gln Ser Ser Cys Leu Cys 
                565                 570                 575     


Glu Glu Ile Thr Gln Leu Lys Ser Phe Ala Arg Met Gly Asn Pro Ile 
            580                 585                 590         


Ser Asn Leu Lys Glu Val Met Met Val Asp Ala Ile Gln Ile Leu Gly 
        595                 600                 605             


Thr Glu Lys Ser Glu Gln Glu Leu Gln Ser Met Ala Cys Phe Phe Phe 
    610                 615                 620                 


Arg Asp Lys Asn Gly Lys Lys Leu Asn Ala Gly Glu His Gly Met Arg 
625                 630                 635                 640 


Asn Phe Ile Gly Asn Asn Val Ile Ser Asn Thr Arg Phe Gln Tyr Leu 
                645                 650                 655     


Ile Arg Tyr Gly Asn Pro Gln Lys Leu His Thr Leu Ser Gln Asn Glu 
            660                 665                 670         


Thr Val Val Arg Phe Val Leu Ser Arg Ile Ala Lys Asn Gln Arg Val 
        675                 680                 685             


Gln Gly Met Asn Gly Lys Asn Gln Ile Asp Arg Tyr Tyr Glu Thr Cys 
    690                 695                 700                 


Gly Gly Thr Asn Ser Trp Ser Val Ser Glu Glu Glu Lys Ile Asn Phe 
705                 710                 715                 720 


Leu Cys Lys Ile Leu Thr Asn Met Ser Tyr Asp Gln Phe Gln Asp Val 
                725                 730                 735     


Lys Gln Ser Asp Lys Ile Ile Thr Ala Glu Glu Lys Arg Lys Lys Glu 
            740                 745                 750         


Arg Tyr Lys Ala Ile Ile Ser Leu Tyr Leu Thr Val Leu Tyr Gln Leu 
        755                 760                 765             


Ile Lys Asn Leu Val Asn Ile Asn Ala Arg Tyr Ile Ile Ala Phe His 
    770                 775                 780                 


Cys Leu Glu Arg Asp Ala Ile Leu Tyr Ser Leu Lys Phe Asn Thr Ser 
785                 790                 795                 800 


Ile Asn Leu Lys Lys Arg Tyr Thr Ala Leu Thr Glu Met Ile Leu Gly 
                805                 810                 815     


Tyr Glu Thr Asp Glu Lys Ala Arg Arg Lys Asp Thr Arg Thr Ile Tyr 
            820                 825                 830         


Glu Lys Ala Glu Ala Ala Lys Asn Arg His Leu Lys Asn Val Lys Trp 
        835                 840                 845             


Asn Cys Lys Thr Arg Glu Asn Leu Glu Asn Ala Asp Lys Asn Ala Ile 
    850                 855                 860                 


Val Ala Phe Arg Asn Ile Val Ala His Leu Trp Ile Ile Arg Asp Ala 
865                 870                 875                 880 


Asp Arg Phe Ile Thr Glu Met Gly Ala Met Lys Arg Tyr Phe Asp Cys 
                885                 890                 895     


Tyr His Tyr Leu Leu Gln Arg Glu Leu Glu Tyr Ile Leu Glu Lys Ser 
            900                 905                 910         


Asn Gln Gly Ser Lys Tyr Thr Lys Lys Ser Leu Glu Lys Val Gln Gln 
        915                 920                 925             


Tyr His Ser Tyr Cys Lys Asp Phe Leu His Met Leu Cys Leu Pro Phe 
    930                 935                 940                 


Ala Tyr Cys Ile Pro Arg Tyr Lys Asn Leu Ser Ile Ala Glu Leu Phe 
945                 950                 955                 960 


Asp Arg His Glu Leu Glu Ala Glu Pro Lys Glu Glu Ala Ser Pro Ala 
                965                 970                 975     


Asn Asn Ser Gln Phe Ile Thr Thr 
            980                 


<210>  3289
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3289

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Glu Gly 
                325                 330                 335     


Asn Lys Ile Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Pro Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn His Tyr 
                405                 410                 415     


Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3290
<211>  921
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3290

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Lys 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Ser Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Leu Glu Asn Glu Ser Asn Asn Asp Phe 
        195                 200                 205             


Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val Phe Thr Asp Pro 
    210                 215                 220                 


Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn Ile Lys Lys Ser 
225                 230                 235                 240 


Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg Leu Gly Tyr Phe 
                245                 250                 255     


Gly Leu Glu Glu Pro Lys Thr Lys Asp Lys Arg Val Ser Glu Ala Tyr 
            260                 265                 270         


Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg Gln 
        275                 280                 285             


Ser Val Phe His Asp Lys Ser Asn Glu Leu Asp Glu Tyr Leu Tyr Ser 
    290                 295                 300                 


Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr Leu 
305                 310                 315                 320 


Ile Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly Asn 
                325                 330                 335     


Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu Ala 
            340                 345                 350         


Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser Gln 
        355                 360                 365             


Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu Asp 
    370                 375                 380                 


Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg Ser 
385                 390                 395                 400 


Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr Arg 
                405                 410                 415     


Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe Ser 
            420                 425                 430         


Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Glu Lys 
        435                 440                 445             


Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His Met 
    450                 455                 460                 


Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe Asp 
465                 470                 475                 480 


Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu Tyr 
                485                 490                 495     


Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys Glu 
            500                 505                 510         


Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile Lys 
        515                 520                 525             


Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys Glu 
    530                 535                 540                 


Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr Asn 
545                 550                 555                 560 


Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala Ala 
                565                 570                 575     


Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly Ile 
            580                 585                 590         


Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu Lys 
        595                 600                 605             


Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn Asn 
    610                 615                 620                 


Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn Ala 
625                 630                 635                 640 


Gln Lys Ile Arg Lys Val Ala Glu Asn Glu Lys Val Val Met Phe Val 
                645                 650                 655     


Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser Cys 
            660                 665                 670         


Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser Glu 
        675                 680                 685             


Leu Ala Arg Met Ile Lys Asn Ile Arg Phe Asp Asp Phe Lys Asn Val 
    690                 695                 700                 


Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala Lys 
705                 710                 715                 720 


Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys Asn 
                725                 730                 735     


Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu Glu 
            740                 745                 750         


Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser Lys 
        755                 760                 765             


Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu Leu 
    770                 775                 780                 


Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn Lys 
785                 790                 795                 800 


Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser 
                805                 810                 815     


Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg 
            820                 825                 830         


Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe 
        835                 840                 845             


Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp 
    850                 855                 860                 


Asp Lys Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys 
865                 870                 875                 880 


Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe 
                885                 890                 895     


Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe 
            900                 905                 910         


Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920     


<210>  3291
<211>  923
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3291

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Val Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Glu Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asn Ser Ser Asn Ile Glu Leu Arg Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Gly Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu His Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Asp Asp Tyr 
            340                 345                 350         


Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys 
        355                 360                 365             


Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met 
    370                 375                 380                 


Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val 
385                 390                 395                 400 


Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr 
                405                 410                 415     


Tyr Arg Asn Asp Val Ile Ala Gly Glu Ala Leu Val Arg Lys Leu Arg 
            420                 425                 430         


Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala 
        435                 440                 445             


Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp 
    450                 455                 460                 


His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp 
465                 470                 475                 480 


Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu 
                485                 490                 495     


Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly 
            500                 505                 510         


Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn 
        515                 520                 525             


Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu 
    530                 535                 540                 


Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile 
545                 550                 555                 560 


Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro 
                565                 570                 575     


Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu 
            580                 585                 590         


Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys 
        595                 600                 605             


Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr 
    610                 615                 620                 


Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala 
625                 630                 635                 640 


Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met 
                645                 650                 655     


Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys 
            660                 665                 670         


Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg 
        675                 680                 685             


Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys 
    690                 695                 700                 


Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg 
705                 710                 715                 720 


Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val 
                725                 730                 735     


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys 
            740                 745                 750         


Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala 
        755                 760                 765             


Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys 
    770                 775                 780                 


Glu Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys 
785                 790                 795                 800 


Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp 
                805                 810                 815     


Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val 
            820                 825                 830         


Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser 
        835                 840                 845             


Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg 
    850                 855                 860                 


Glu Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu 
865                 870                 875                 880 


Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser 
                885                 890                 895     


Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln 
            900                 905                 910         


Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920             


<210>  3292
<211>  923
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3292

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Val Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Glu Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asn Ser Ser Asn Ile Glu Leu Arg Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Gly Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu His Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Asp Asp Tyr 
            340                 345                 350         


Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys 
        355                 360                 365             


Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met 
    370                 375                 380                 


Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val 
385                 390                 395                 400 


Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr 
                405                 410                 415     


Tyr Arg Asn Asp Val Ile Ala Gly Glu Ala Leu Val Arg Lys Leu Arg 
            420                 425                 430         


Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala 
        435                 440                 445             


Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp 
    450                 455                 460                 


His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp 
465                 470                 475                 480 


Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu 
                485                 490                 495     


Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly 
            500                 505                 510         


Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn 
        515                 520                 525             


Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu 
    530                 535                 540                 


Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile 
545                 550                 555                 560 


Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro 
                565                 570                 575     


Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu 
            580                 585                 590         


Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys 
        595                 600                 605             


Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr 
    610                 615                 620                 


Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala 
625                 630                 635                 640 


Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met 
                645                 650                 655     


Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys 
            660                 665                 670         


Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg 
        675                 680                 685             


Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys 
    690                 695                 700                 


Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg 
705                 710                 715                 720 


Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val 
                725                 730                 735     


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys 
            740                 745                 750         


Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala 
        755                 760                 765             


Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys 
    770                 775                 780                 


Glu Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys 
785                 790                 795                 800 


Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp 
                805                 810                 815     


Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val 
            820                 825                 830         


Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser 
        835                 840                 845             


Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg 
    850                 855                 860                 


Glu Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu 
865                 870                 875                 880 


Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser 
                885                 890                 895     


Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln 
            900                 905                 910         


Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920             


<210>  3293
<211>  925
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3293

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Glu Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Lys Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asp Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Glu Asp Ser Ser Asn Ile Glu Leu Cys Gly 
            100                 105                 110         


Val Thr Lys Val Asn Ile Thr Phe Ser Ser Lys Arg Gly Asn Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Asp Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu His Glu 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Ile Ala Val Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Gly His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Cys Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Asp Arg Asp Lys Ser Pro Asn Leu Phe Leu 
785                 790                 795                 800 


Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn 
                805                 810                 815     


Ala Asp Ser Val Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu 
            820                 825                 830         


Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val 
        835                 840                 845             


Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr 
    850                 855                 860                 


Lys Arg Glu Asp Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp 
865                 870                 875                 880 


Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu 
                885                 890                 895     


Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile 
            900                 905                 910         


Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925 


<210>  3294
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3294

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Phe Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Asn Arg Val Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Ile Ala Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Leu Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asn Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Lys Val Ala Glu Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Glu Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asp Asp Lys 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Phe Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  3295
<211>  926
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3295

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Ala Ala Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Val Tyr Asn 
                85                  90                  95      


Gln Thr Gln Leu Ser Ser Lys Gly Ser Ser Asn Ile Lys Leu Cys Gly 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn 
225                 230                 235                 240 


Val Arg Lys Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu His Glu 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Asp Asp Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile 
        355                 360                 365             


Val Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg 
    370                 375                 380                 


Glu Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe 
                405                 410                 415     


Cys Asn Tyr Tyr Arg Asn Asp Val Ile Ala Gly Glu Ala Leu Val Arg 
            420                 425                 430         


Lys Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala 
        435                 440                 445             


Asp Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn 
    450                 455                 460                 


Ile Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala 
465                 470                 475                 480 


Asp Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala 
                485                 490                 495     


Ser Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe 
            500                 505                 510         


Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys 
        515                 520                 525             


Phe Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val 
    530                 535                 540                 


Asp Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser 
545                 550                 555                 560 


Gln Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met 
                565                 570                 575     


Arg Lys Pro Ala Ala Ser Ala Met Leu Thr Met Phe Arg Asp Ala Leu 
            580                 585                 590         


Thr Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu 
        595                 600                 605             


Ile Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn 
    610                 615                 620                 


Phe Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile 
625                 630                 635                 640 


Lys Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys 
                645                 650                 655     


Val Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg 
            660                 665                 670         


Tyr Tyr Lys Ser Cys Val Glu Val Pro Asp Met Asn Ser Ser Leu Glu 
        675                 680                 685             


Ala Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Ser Ile Ser Phe Asp 
    690                 695                 700                 


Asp Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala 
705                 710                 715                 720 


Lys Glu Met Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr 
                725                 730                 735     


Leu Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala 
            740                 745                 750         


Ile His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Ser 
        755                 760                 765             


Glu Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln 
    770                 775                 780                 


Thr Leu Cys Glu Leu Cys Asp Asn Cys Asp Glu Ser Pro Asn Leu Phe 
785                 790                 795                 800 


Leu Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn 
                805                 810                 815     


Asn Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His 
            820                 825                 830         


Leu Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr 
        835                 840                 845             


Val Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile 
    850                 855                 860                 


Thr Lys Arg Glu Asp Asp Lys Lys Gln Glu Glu Lys Ile Lys Tyr Glu 
865                 870                 875                 880 


Asp Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala 
                885                 890                 895     


Leu Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser 
            900                 905                 910         


Ile Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925     


<210>  3296
<211>  1023
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3296

Met Ala Lys Lys Ile Thr Ala Lys Gln Lys Arg Glu Glu Lys Glu Arg 
1               5                   10                  15      


Leu Asn Lys Gln Lys Trp Ala Lys Gln Asp Thr Pro Val Val Pro Lys 
            20                  25                  30          


Ser Lys Thr Glu Glu Lys Pro Val Ala Ala Ser Asp Asp Lys Leu Leu 
        35                  40                  45              


Lys Thr Thr Gln Val Lys Lys Val Gln Thr Lys Ser Lys Ala Lys Ala 
    50                  55                  60                  


Met Gly Leu Lys Thr Val Leu Ser Phe Asp Asp Lys Ile Ala Ile Ala 
65                  70                  75                  80  


Ser Phe Val Asn Asp Lys Lys Thr Lys Leu Pro His Ile Glu Arg Ile 
                85                  90                  95      


Thr Asp Lys Ser Gly Thr Thr Ile His Glu Asn Ala Arg Met Phe Asp 
            100                 105                 110         


Ser Ser Val Asp Glu Gln Asn Val Asn Ile Glu Lys Arg Met Thr Ile 
        115                 120                 125             


Glu Glu Lys Gln Asn Asp Gly Thr Phe Lys Lys Asp Glu Lys Asp Val 
    130                 135                 140                 


Lys Ala Thr Ile Cys Asn Pro Tyr Phe Lys Thr Cys Gly Lys Asp Tyr 
145                 150                 155                 160 


Ile Gly Ile Lys Asp Val Ala Glu Lys Tyr Phe Phe Gly Lys Thr Phe 
                165                 170                 175     


Pro Asn Glu Asn Leu Arg Val Gln Ile Ala Tyr Asn Val Phe Asp Ile 
            180                 185                 190         


Gln Lys Ile Leu Gly Thr Tyr Val Asn Asn Ile Ile Tyr Ser Phe Tyr 
        195                 200                 205             


Asn Leu Arg Arg Asp Gly Lys Ser Asp Val Asp Ile Ile Gly Ser Leu 
    210                 215                 220                 


Tyr Ala Phe Ala Asp Phe Asp Asn Gln Leu Lys Asp Lys Pro Ala Phe 
225                 230                 235                 240 


Arg Glu Ala Lys Asp Leu Leu Lys Asn Thr Glu Ala Tyr Phe Ser Tyr 
                245                 250                 255     


Phe Gly Asp Val Phe Lys Lys Ser Lys Lys Gly Lys Lys Asp Glu Asn 
            260                 265                 270         


Asn Glu Asp Tyr Glu Lys Asn Leu Arg His Asn Phe Asn Val Leu Arg 
        275                 280                 285             


Val Leu Ser Phe Leu Arg Gln Ile Cys Thr His Ala Tyr Val Lys Cys 
    290                 295                 300                 


Thr Ser Gly Ala Lys Asn Asn Gly Asp Ser Thr Lys Val Val Ala Glu 
305                 310                 315                 320 


Ser Leu Asp Ala Leu Phe Asn Ile Thr Glu Tyr Phe Asp Lys Thr Ala 
                325                 330                 335     


Pro Glu Leu Ser Lys Thr Ile Asn Glu Ile Tyr Lys Glu Gly Val Asp 
            340                 345                 350         


Arg Ile Asn Asn Asp Phe Val Thr Asn Gly Lys Asn Asn Leu Tyr Ile 
        355                 360                 365             


Leu Ser Lys Val Tyr Pro Asp Met Gln Arg Asn Glu Leu Val Lys Lys 
    370                 375                 380                 


Tyr Tyr Gln Phe Val Val Cys Lys Glu Gly Asn Asn Val Gly Ile Asn 
385                 390                 395                 400 


Thr Arg Lys Leu Lys Glu Ser Ile Ile Ser Gln Asn Pro Trp Ile Thr 
                405                 410                 415     


Thr Pro Gln Asp Asn Asn Lys Ala Asn Asp Tyr Lys Ser Cys Gln His 
            420                 425                 430         


Lys Leu Tyr Thr Ile Met Cys Phe Ile Leu Val Ala Glu Leu Asp Ala 
        435                 440                 445             


His Glu Ser Ile Arg Asp Asn Met Val Ala Glu Leu Arg Ala Asn Met 
    450                 455                 460                 


Asp Gly Asp Asp Gly Arg Asp Ala Ile Tyr Glu Lys Tyr Ala Lys Asp 
465                 470                 475                 480 


Ile Tyr His Ile Val Lys Asp Lys Leu Leu Ala Met Gln Lys Val Phe 
                485                 490                 495     


Asp Glu Glu Leu Val Pro Val Lys Val Glu Glu Glu Asn Asp Pro Gln 
            500                 505                 510         


Arg Phe Thr His Gly Lys Leu Gly Lys Lys Glu Ile Glu Ser Phe Cys 
        515                 520                 525             


Leu Ser Asp Lys Asn Thr Ser Asp Ile Ala Lys Val Val Tyr Phe Leu 
    530                 535                 540                 


Cys Asn Phe Leu Asp Gly Lys Glu Ile Asn Glu Leu Cys Cys Ala Met 
545                 550                 555                 560 


Met Asn Lys Phe Asp Gly Ile Gly Asp Leu Ile Asp Thr Ala Lys Gln 
                565                 570                 575     


Cys Gly Glu Glu Val Lys Phe Ile Glu Lys Phe Ala Cys Leu Ser Asn 
            580                 585                 590         


Cys Arg Lys Ile Thr Asp Asp Ile Arg Val Ala Lys Ser Ile Ser Lys 
        595                 600                 605             


Met Lys Asn Lys Val Lys Ile Asp Asn Asp Ile Ile Tyr Leu Asp Ala 
    610                 615                 620                 


Ile Glu Leu Leu Gly Arg Lys Ile Glu Lys Tyr Gln Lys Asp Glu Ser 
625                 630                 635                 640 


Gly Lys Ile Leu Leu Gly Thr Asp Gly Lys Arg Leu Tyr Thr Lys Glu 
                645                 650                 655     


Tyr Lys Tyr Phe Asn Asp Met Phe Phe Asn Ala Gly Asn His Lys Val 
            660                 665                 670         


Arg Lys Phe Ile Asn Asn Asn Val Met Lys Ser Lys Trp Phe Phe Tyr 
        675                 680                 685             


Val Val Arg Tyr Asn Lys Pro Ala Glu Cys Gln Ile Ile Met Arg Asn 
    690                 695                 700                 


Lys Thr Leu Val Lys Phe Thr Leu Asp Asp Leu Pro Asp Glu Gln Ile 
705                 710                 715                 720 


Gln Arg Tyr Tyr Ser Ser Val Phe Gly Asp Asn Asn Met Pro Thr Val 
                725                 730                 735     


Asp Val Met Arg Glu Trp Leu Leu Lys Lys Ile Asn Gln Phe Ser Val 
            740                 745                 750         


Arg Gly Phe Leu Asp Asp Ile Asp Glu Glu Ser Lys Gln Asn Lys Ser 
        755                 760                 765             


Ser Glu Thr Glu Gln Lys Lys Ser Leu Ile Arg Leu Tyr Leu Thr Ile 
    770                 775                 780                 


Ala Tyr Leu Ile Thr Lys Ser Met Val Lys Ile Asn Thr Arg Phe Ser 
785                 790                 795                 800 


Ile Ala Cys Ala Thr Tyr Glu Arg Asp Tyr Ala Leu Leu Cys Gln Ser 
                805                 810                 815     


Gln Gln Lys Gly Gly Pro Trp Asp Gly Gly Ala Gln Ala Leu Ala Val 
            820                 825                 830         


Thr Arg Lys Phe Leu Asn His Asp Arg Glu Ile Phe Asp Arg Tyr Cys 
        835                 840                 845             


Ala Arg Glu Ala Glu Ile Ala Arg Leu Pro Ser Glu Glu Arg Lys Pro 
    850                 855                 860                 


Leu Arg Lys Ala Asn Asp Lys Leu Leu Lys Gln Thr His Tyr Thr Asn 
865                 870                 875                 880 


His Ser Tyr Thr Tyr Ile Val Asn Asn Leu Asn Ser Phe Thr Asp Ile 
                885                 890                 895     


Asp Tyr Cys Ala Lys Asp Val Gly Leu Pro Ala Pro Asn Asp Lys Asn 
            900                 905                 910         


Asp Asn Ala Ser Ile Leu Gly Glu Met Arg Asn Asp Ile Ala His Leu 
        915                 920                 925             


Asn Val Val His Asp Met Val Lys Tyr Ile Glu Glu Leu Lys Asp Ile 
    930                 935                 940                 


Ser Ser Tyr Tyr Ala Phe Tyr Cys Tyr Val Leu Gln Arg Arg Leu Val 
945                 950                 955                 960 


Gly Asn Asp Pro Asn Cys Gln Asn Lys Phe Lys Ala Lys Tyr Ala Lys 
                965                 970                 975     


Glu Leu Asn Tyr Tyr Gly Thr Tyr Asn Lys Asn Leu Met Trp Met Leu 
            980                 985                 990         


Asn Leu Pro Phe Ala Tyr Asn Leu  Pro Arg Tyr Lys Asn  Leu Ser Ser 
        995                 1000                 1005             


Glu Phe  Leu Phe Tyr Asp Met  Glu Tyr Asn Lys Lys  Asp Asp Glu 
    1010                 1015                 1020             


<210>  3297
<211>  946
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3297

Met Lys Lys Phe Ser Asn Ile Lys Arg Leu Gly Val Lys Ser Val His 
1               5                   10                  15      


Tyr Ala Asn Asn Thr Val Ile Val Glu Asp His Phe Ser Lys Asn Thr 
            20                  25                  30          


Asn Ile Leu Phe Thr Ala Glu Tyr Glu Asn Ile Asp Asp Leu Lys Ser 
        35                  40                  45              


Cys Thr Asn Ile Asp Lys Thr Ala Glu Asn Lys Gly Val Arg Phe Thr 
    50                  55                  60                  


Asp Leu Lys Asn Lys Asn Gly Phe Glu Leu Ser Ala Met Ala Gln Lys 
65                  70                  75                  80  


Gln Ile Leu Lys Ser Arg Val Asn Arg Val Lys Lys Val Ser Tyr Thr 
                85                  90                  95      


Gln Glu Leu Phe Asp Ile Thr Thr Asp Asn Asn Ile Glu Val Gln Ile 
            100                 105                 110         


Phe Ser Asn Leu Glu Asp Val Lys Lys Val Ile Ala Pro Tyr Tyr Asn 
        115                 120                 125             


Asn Val Ala Tyr Ala Ile Asn Ser Leu Tyr Arg Asp Ile Ser Asn Asp 
    130                 135                 140                 


Asp Ser Tyr Gly Phe Asp Lys Ile Gly Ser Ile Pro Val Asp Ala Asp 
145                 150                 155                 160 


Trp Tyr Asn Phe Leu Lys Asp Ala Pro Asp Lys Lys Glu Lys Trp Thr 
                165                 170                 175     


Thr Tyr Ile Ile Pro Ser Tyr Lys Lys Val Ile Ala Arg Phe Gly Ile 
            180                 185                 190         


Gln Met Glu Lys Asn Gln Gln Val Asn Phe Cys Lys Cys Leu Glu Tyr 
        195                 200                 205             


Val Ala Ile Arg Asn Gly Leu Phe Val Lys Phe Lys Asp Glu Lys Val 
    210                 215                 220                 


Asp Pro Asp Lys Leu Leu Asn Lys Lys Ile Gln Glu Lys Leu Asp Lys 
225                 230                 235                 240 


Leu Ile Ser Asp Lys Glu Val Asn Asp Lys Leu Phe Glu Leu Ala Lys 
                245                 250                 255     


Thr Pro Val Ser Glu Phe Cys Ala Glu Ala Asn Ala Ile Pro Leu Tyr 
            260                 265                 270         


Arg Tyr Ala Phe Ile Gly Gln Lys Gly Lys Arg Ile Glu Lys Ile Val 
        275                 280                 285             


Leu Asp Lys Leu Glu Glu Asn Glu Ile Leu Ser Ser Leu Val Arg Lys 
    290                 295                 300                 


Ile Asp Glu Asn Glu Thr Thr Tyr Asn Tyr Leu Arg Leu Leu Ser Ala 
305                 310                 315                 320 


Ile Arg Gln Tyr Val Val His Asn Ser Arg Lys Val Arg Ile Asp Lys 
                325                 330                 335     


Asn Val Phe Ile Asn Asp Thr Ala Lys Arg Asp Val Glu Glu Phe Ala 
            340                 345                 350         


Lys Gln Phe Gln Lys Asn Asn Tyr Lys Tyr Phe Cys Ile Leu Lys Glu 
        355                 360                 365             


Leu Tyr Ser Asp Ser Asp Ile Leu Glu Gln Phe Phe Asp Tyr Thr Val 
    370                 375                 380                 


Phe Asp Glu Ala Arg Asn Leu Lys Ile Ser Ile Asp Lys Ile Lys Lys 
385                 390                 395                 400 


Gly Ile Thr Ala Asn Ile Asp Ile Ser Ala Asp Val Glu Pro Asp Lys 
                405                 410                 415     


Leu Ser Glu Tyr Ala Asn Lys Phe Arg Thr Val Thr Met Phe Ala Leu 
            420                 425                 430         


Thr Lys Tyr Leu Lys Glu Asn Val Gly Glu Ile Glu Asp Phe Leu Ala 
        435                 440                 445             


Asn Ile Lys Val Cys Ser Ser Asp Glu Glu Lys Ala Gly Val Tyr Glu 
    450                 455                 460                 


Gln Lys Ala Lys Glu Phe Ile Thr Lys Phe Asp Ser Phe Lys Asp Ile 
465                 470                 475                 480 


Arg Ser Val Val Lys Lys His Leu Gly Thr Gln Lys Val Asn Glu Lys 
                485                 490                 495     


Phe Asp Phe Tyr Pro Ser Asp Ile Asn Phe Gly Arg Asp Ser Asn Val 
            500                 505                 510         


Phe Phe Asn Met Leu Tyr Val Met Ser Lys Phe Leu Thr Val Asn Glu 
        515                 520                 525             


Ala Arg Ile Met Phe Gln Lys Ile Lys Ser Lys Tyr Asp Ser Val Lys 
    530                 535                 540                 


Ser Leu Leu Lys Ile Ala Glu Leu Thr Gly Val Thr Leu Ser Asp Asn 
545                 550                 555                 560 


Leu Phe Asp Arg Phe Arg Met Ile Phe Asp Lys Glu Arg Val Asp Glu 
                565                 570                 575     


Tyr Gln Lys Gln Leu Ile Val Leu Gln Ser Ile Arg Thr Arg Asn Gly 
            580                 585                 590         


Val Ser Gln Glu Gly Phe Ala Lys Glu Leu Lys Arg Ile Phe Asp Met 
        595                 600                 605             


Phe Lys Lys Asp Asp Ile Ser Tyr Glu Glu Phe Glu Lys Glu Leu Ser 
    610                 615                 620                 


Leu Asp Glu Asn Gln Asn Glu Ile Lys Asn Lys Ser Phe Lys Leu Lys 
625                 630                 635                 640 


Pro Leu Lys Ser Tyr Leu Arg Asn Asp Val Tyr Lys Ser Lys Gln Tyr 
                645                 650                 655     


Gln Tyr Ile Ser Ser Phe Ala Ser Ala Gly Ile Cys Gln Lys Ile Met 
            660                 665                 670         


Glu Asn Lys Asp Ile Val Ala Phe Val Leu Asn Gly Met Leu Tyr Gln 
        675                 680                 685             


Glu Gly Lys Leu Ser Met Pro Met His Lys Tyr Val Ala Lys Val Tyr 
    690                 695                 700                 


His Asp Phe Arg Arg Glu Lys Ile Asp Glu Asn Ser Ala Asn Tyr Leu 
705                 710                 715                 720 


Leu Asp Gln Asn Gln Ile Ser Ser Leu Val Asn Ser Leu Cys Asp Leu 
                725                 730                 735     


Lys Leu Glu Asn Ile Ile Glu Ala Ile Phe Lys Glu Ser Arg Val Asn 
            740                 745                 750         


Tyr Lys Ala Leu Val Arg Leu Tyr Leu Asn Ile Cys Tyr Leu Phe Val 
        755                 760                 765             


Lys Asn Ile Ile Ser Leu Asn Ser Thr Tyr Leu Ile Gln Phe Gln Asp 
    770                 775                 780                 


Tyr Glu Asn Ile Tyr Lys Gln Leu His Leu Glu Asp Leu Met Asp Ile 
785                 790                 795                 800 


Thr Tyr Asp Phe Gly Val Leu Asn Asn Phe Val Glu Asn Ala Pro Asn 
                805                 810                 815     


Lys Lys Cys Arg Ser Tyr Met Gln Leu Gln Thr Leu Leu Glu Lys Asp 
            820                 825                 830         


Tyr Ile Lys Asp Tyr Ile Tyr Thr Pro Glu Tyr Gln Val Leu Gln Asp 
        835                 840                 845             


Arg Tyr Arg Asn Leu Val Val His Ser Ser Leu Leu Phe Gly Leu Asp 
    850                 855                 860                 


Lys Ile Asp Phe Asp Phe Gly Glu Val Gln Asn Ile Ser Ser Tyr Phe 
865                 870                 875                 880 


Ala Ile Tyr Gln Thr Leu Val Gln Arg Leu Val Glu Gln Asp Ala Arg 
                885                 890                 895     


Glu Val Trp Gly Glu Lys Phe Asp Glu Tyr Phe Ala Leu Asn Asn Gly 
            900                 905                 910         


Lys Thr Tyr Ser Thr Lys Leu Cys Ile Ala Leu Asn Met Pro Tyr Ala 
        915                 920                 925             


Tyr Asn Ile Ser Arg Phe Asn Asn Asn Thr Ile Glu Lys Tyr Ser Asn 
    930                 935                 940                 


Lys Arg 
945     


<210>  3298
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3298

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Gln Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Ile Lys Gly Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Ser Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ser Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Lys Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Arg Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3299
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3299

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Gln Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Arg Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Asp Glu Ser 
        195                 200                 205             


His Asp Asp Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val 
    210                 215                 220                 


Phe Thr Asp Pro Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Asn Ala 
            260                 265                 270         


Leu Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Glu Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Lys Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Arg Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3300
<211>  919
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3300

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Cys Asp Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Ile Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Ile Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Ala Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Asn Arg Val Ser Glu Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu His Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Ile Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Glu 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ser Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Lys Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn Arg Arg Leu 
785                 790                 795                 800 


Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser Ser Met Thr 
                805                 810                 815     


Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val Arg Glu Leu 
            820                 825                 830         


Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr Phe Ser Ile 
        835                 840                 845             


Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu Asn Asp Thr 
    850                 855                 860                 


Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu Lys Asn His 
865                 870                 875                 880 


Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro Phe Gly Tyr 
                885                 890                 895     


Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu Phe Asp Arg 
            900                 905                 910         


Asn Glu Tyr Leu Thr Glu Lys 
        915                 


<210>  3301
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3301

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Gln Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Arg Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Asp Glu Ser 
        195                 200                 205             


His Asp Asp Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val 
    210                 215                 220                 


Phe Thr Asp Pro Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Asn Ala 
            260                 265                 270         


Leu Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Glu Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Lys Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Arg Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3302
<211>  926
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3302

Met Leu Leu Cys Ala Ile Ile Gln Ala Ser Thr Lys Arg Asp Arg Lys 
1               5                   10                  15      


Gly Gly Val Arg Met Glu Arg Glu Val Lys Lys Pro Pro Lys Lys Ser 
            20                  25                  30          


Leu Ala Lys Ala Ala Gly Leu Lys Ser Thr Phe Val Ile Ser Pro Gln 
        35                  40                  45              


Glu Lys Glu Leu Ala Met Thr Ala Phe Gly Arg Gly Asn Asp Ala Leu 
    50                  55                  60                  


Leu Gln Lys Arg Ile Val Asp Gly Val Val Arg Asp Val Ala Gly Glu 
65                  70                  75                  80  


Lys Gln Gln Phe Gln Val Gln Arg Gln Asp Glu Ser Arg Phe Arg Leu 
                85                  90                  95      


Gln Asn Ser Arg Leu Ala Asp Arg Thr Val Thr Ala Asp Asp Pro Leu 
            100                 105                 110         


His Arg Ala Glu Thr Pro Arg Arg Gln Pro Leu Gly Ala Gly Met Asp 
        115                 120                 125             


Gln Leu Arg Arg Lys Ala Ile Leu Glu Gln Lys Tyr Phe Gly Arg Thr 
    130                 135                 140                 


Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile Leu Asp Ile 
145                 150                 155                 160 


His Lys Met Leu Ala Val Pro Ala Asn His Ile Val His Thr Leu Asn 
                165                 170                 175     


Leu Leu Gly Gly Tyr Gly Glu Thr Asp Phe Val Gly Met Leu Pro Ala 
            180                 185                 190         


Gly Leu Pro Tyr Asp Lys Leu Arg Val Val Lys Lys Lys Asn Gly Asp 
        195                 200                 205             


Thr Val Asp Ile Lys Ala Asp Ile Ala Ala Tyr Ala Lys Arg Pro Gln 
    210                 215                 220                 


Leu Ala Tyr Leu Gly Ala Ala Phe Tyr Asp Ala Thr Pro Gly Lys Ser 
225                 230                 235                 240 


Lys Arg Asp Ala Ala Arg Gly Arg Val Lys Arg Glu Gln Asp Val Tyr 
                245                 250                 255     


Thr Ile Leu Ser Leu Met Ser Leu Leu Arg Gln Phe Cys Ala His Asp 
            260                 265                 270         


Ser Val Arg Ile Trp Gly Gln Asn Thr Thr Ala Ala Leu Tyr His Leu 
        275                 280                 285             


Gln Ala Leu Pro Gln Asp Met Lys Asp Leu Leu Asp Asp Gly Trp Arg 
    290                 295                 300                 


Arg Ala Leu Gly Gly Val Asn Asp His Phe Leu Asp Thr Asn Lys Val 
305                 310                 315                 320 


Asn Leu Leu Thr Leu Phe Glu Tyr Tyr Gly Ala Glu Thr Lys Gln Ala 
                325                 330                 335     


Arg Val Ala Leu Met Gln Asp Phe Tyr Arg Phe Val Val Leu Lys Glu 
            340                 345                 350         


Gln Lys Asn Met Gly Phe Ser Leu Arg Arg Leu Arg Glu Glu Leu Leu 
        355                 360                 365             


Lys Leu Pro Asp Ala Ala Tyr Leu Thr Gly Gln Glu Tyr Asp Ser Val 
    370                 375                 380                 


Arg Gln Lys Leu Tyr Met Leu Leu Asp Phe Leu Leu Cys Arg Leu Tyr 
385                 390                 395                 400 


Ala Gln Glu Arg Ala Gly Arg Cys Glu Glu Leu Val Ser Ala Leu Arg 
                405                 410                 415     


Cys Ala Leu Ser Asp Glu Glu Lys Asp Ala Val Tyr Gln Ala Glu Ala 
            420                 425                 430         


Ala Ala Leu Trp Gln Ala Leu Gly Asp Thr Leu Arg Arg Glu Leu Leu 
        435                 440                 445             


Pro Leu Leu Lys Gly Lys Lys Leu Gln Asp Lys Asp Lys Lys Lys Pro 
    450                 455                 460                 


Asp Glu Val Gly Leu Ser Arg Asp Val Leu Asp Gly Val Leu Phe Arg 
465                 470                 475                 480 


Pro Ala Gln Gln Gly Asn Arg Ala Asn Ala Asp Tyr Phe Cys Arg Leu 
                485                 490                 495     


Met His Leu Ser Thr Trp Phe Met Asp Gly Lys Glu Ile Asn Thr Leu 
            500                 505                 510         


Leu Thr Thr Leu Ile Ser Lys Phe Glu Asn Ile Asp Ser Leu Arg Asn 
        515                 520                 525             


Val Leu Glu Ser Met Gly Leu Ala Cys Ser Phe Val Pro Ala Tyr Ala 
    530                 535                 540                 


Met Phe Asp His Ser Arg Tyr Ile Ala Gly Gln Leu Arg Val Val Asn 
545                 550                 555                 560 


Asn Ile Ala Arg Met Arg Lys Pro Ala Ile Gly Ala Lys Arg Glu Met 
                565                 570                 575     


Tyr Arg Ala Ala Val Val Leu Leu Gly Val Asp Ser Pro Glu Ala Ala 
            580                 585                 590         


Ala Ala Ile Thr Asp Asp Leu Leu Gln Ile Asp Pro Glu Thr Gly Lys 
        595                 600                 605             


Val Arg Pro Arg Gly Asp Ser Ala Arg Asp Thr Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Ala Asn Asn Val Val Glu Ser Arg Arg Phe Thr Tyr Leu Leu Arg 
625                 630                 635                 640 


Tyr Met Thr Pro Glu Gln Ala Arg Val Leu Ala Gln Asn Glu Lys Leu 
                645                 650                 655     


Ile Ala Phe Val Leu Ser Thr Val Pro Asp Thr Gln Leu Glu Arg Tyr 
            660                 665                 670         


Cys Arg Thr Cys Gly Arg Glu Asp Ile Thr Gly Arg Pro Ala Gln Ile 
        675                 680                 685             


Arg Tyr Leu Thr Ala Gln Ile Met Gly Val Arg Tyr Glu Ser Phe Thr 
    690                 695                 700                 


Asp Val Glu Gln Arg Gly Arg Gly Asp Asn Pro Arg Lys Glu Arg Tyr 
705                 710                 715                 720 


Lys Ala Leu Ile Gly Leu Tyr Leu Thr Val Leu Tyr Leu Ala Val Lys 
                725                 730                 735     


Asn Met Val Asn Cys Asn Ala Arg Tyr Val Ile Ala Phe Tyr Cys Arg 
            740                 745                 750         


Asp Arg Asp Thr Ala Leu Tyr Gln Lys Glu Val Cys Trp Tyr Asp Leu 
        755                 760                 765             


Glu Glu Asp Lys Lys Ser Gly Lys Gln Arg Gln Val Glu Asp Tyr Thr 
    770                 775                 780                 


Ala Leu Thr Arg Tyr Phe Val Ser Gln Gly Tyr Leu Asn Arg His Ala 
785                 790                 795                 800 


Cys Gly Tyr Leu Arg Ser Asn Met Asn Gly Ile Ser Asn Gly Leu Leu 
                805                 810                 815     


Val Ala Tyr Arg Asn Ala Val Asp His Leu Asn Val Ile Pro Pro Leu 
            820                 825                 830         


Gly Ser Leu Cys Arg Asp Ile Gly Arg Val Asp Ser Tyr Phe Ala Leu 
        835                 840                 845             


Tyr His Tyr Ala Val Gln Gln Tyr Leu Asn Gly Arg Tyr Tyr Arg Lys 
    850                 855                 860                 


Thr Pro Arg Glu Gln Glu Leu Phe Ala Ala Met Ala Gln His Arg Thr 
865                 870                 875                 880 


Trp Cys Ser Asp Leu Val Lys Ala Leu Asn Thr Pro Phe Gly Tyr Asn 
                885                 890                 895     


Leu Ala Arg Tyr Lys Asn Leu Ser Ile Asp Gly Leu Phe Asp Arg Glu 
            900                 905                 910         


Gly Asp His Val Val Arg Glu Asp Gly Glu Lys Pro Ala Glu 
        915                 920                 925     


<210>  3303
<211>  926
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3303

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asp Asp Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Gly Ser Ser Asn Ile Glu Leu His Gly 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Ser Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Phe Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Val Lys Asp Ser Glu Ser 
        195                 200                 205             


Tyr Asp Asp Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Lys Val 
    210                 215                 220                 


Phe Thr His Pro Asp Lys Ser Asn Leu Ser Asp Lys Val Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Phe Ser Thr Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val 
            260                 265                 270         


Ser Gln Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Cys Val Phe His Asp Lys Ser Ser Lys Leu His Glu 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe 
                325                 330                 335     


Ile Glu Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Asp Asp Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile 
        355                 360                 365             


Val Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg 
    370                 375                 380                 


Glu Lys Met Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr 
385                 390                 395                 400 


Asp Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe 
                405                 410                 415     


Cys Asn Tyr Tyr Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg 
            420                 425                 430         


Lys Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala 
        435                 440                 445             


Asp Glu Ala Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn 
    450                 455                 460                 


Ile Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala 
465                 470                 475                 480 


Asp Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala 
                485                 490                 495     


Ser Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe 
            500                 505                 510         


Leu Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys 
        515                 520                 525             


Phe Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val 
    530                 535                 540                 


Asp Val Glu Cys Lys Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser 
545                 550                 555                 560 


Gln Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met 
                565                 570                 575     


Arg Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu 
            580                 585                 590         


Thr Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu 
        595                 600                 605             


Ile Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn 
    610                 615                 620                 


Phe Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile 
625                 630                 635                 640 


Lys Tyr Ala Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys 
                645                 650                 655     


Val Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg 
            660                 665                 670         


Tyr Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu 
        675                 680                 685             


Ala Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp 
    690                 695                 700                 


Asp Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala 
705                 710                 715                 720 


Lys Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr 
                725                 730                 735     


Leu Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala 
            740                 745                 750         


Ile His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro 
        755                 760                 765             


Glu Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln 
    770                 775                 780                 


Thr Leu Cys Glu Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe 
785                 790                 795                 800 


Leu Lys Lys Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn 
                805                 810                 815     


Asn Ala Asp Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His 
            820                 825                 830         


Leu Thr Val Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr 
        835                 840                 845             


Val Asp Ser Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile 
    850                 855                 860                 


Thr Lys Arg Glu Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu 
865                 870                 875                 880 


Asp Asp Leu Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala 
                885                 890                 895     


Leu Asn Ser Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser 
            900                 905                 910         


Ile Glu Gln Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920                 925     


<210>  3304
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3304

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Gln Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Lys Val Asp Asn Asn Asn Tyr Asn 
                85                  90                  95      


Lys Thr Gln Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Arg Asp 
            100                 105                 110         


Val Asn Glu Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser 
        115                 120                 125             


Gly Val Glu Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser 
    130                 135                 140                 


Ser Pro Val Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys 
145                 150                 155                 160 


Arg Phe Phe Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile 
                165                 170                 175     


Tyr Asn Ile Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn 
            180                 185                 190         


Ile Val Tyr Ala Leu Asn Asn Met Leu Gly Glu Gly Asp Asp Glu Ser 
        195                 200                 205             


His Asp Asp Phe Met Gly Tyr Leu Ser Ala Lys Asn Thr Tyr Asp Val 
    210                 215                 220                 


Phe Thr Asp Pro Asp Glu Ser Asp Leu Ser Lys Asn Ile Lys Gly Asn 
225                 230                 235                 240 


Ile Lys Lys Ser Leu Ser Lys Phe Asn Asp Leu Leu Lys Thr Lys Arg 
                245                 250                 255     


Leu Gly Tyr Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Asn Ala 
            260                 265                 270         


Leu Glu Ala Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly 
        275                 280                 285             


Gln Ile Arg Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu Asp Glu 
    290                 295                 300                 


Asp Leu Tyr Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr 
305                 310                 315                 320 


Leu Asp Tyr Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe 
                325                 330                 335     


Ile Gln Gly Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys 
            340                 345                 350         


Gly Tyr Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val 
        355                 360                 365             


Leu Lys Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu 
    370                 375                 380                 


Lys Met Leu Glu Glu Tyr Gly Tyr Arg Phe Lys Asp Lys Gln Tyr Asp 
385                 390                 395                 400 


Ser Val Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys 
                405                 410                 415     


Asn Tyr Tyr Arg Asn Asp Val Ala Ala Gly Glu Ala Leu Val Arg Lys 
            420                 425                 430         


Leu Arg Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp 
        435                 440                 445             


Glu Ala Glu Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile 
    450                 455                 460                 


Ala Asp His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp 
465                 470                 475                 480 


Met Asp Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser 
                485                 490                 495     


Asp Leu Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu 
            500                 505                 510         


Asp Gly Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe 
        515                 520                 525             


Asp Asn Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp 
    530                 535                 540                 


Val Glu Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln 
545                 550                 555                 560 


Arg Ile Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg 
                565                 570                 575     


Lys Pro Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr 
            580                 585                 590         


Ile Leu Gly Ile Asp Asp Lys Ile Thr Asp Asp Arg Ile Ser Glu Ile 
        595                 600                 605             


Leu Lys Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe 
    610                 615                 620                 


Ile Thr Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys 
625                 630                 635                 640 


Tyr Ala Asn Ala Gln Lys Ile Arg Lys Val Ala Lys Asn Glu Lys Val 
                645                 650                 655     


Val Met Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr 
            660                 665                 670         


Tyr Lys Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Val 
        675                 680                 685             


Lys Arg Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp 
    690                 695                 700                 


Phe Lys Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys 
705                 710                 715                 720 


Glu Arg Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu 
                725                 730                 735     


Leu Val Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile 
            740                 745                 750         


His Cys Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu 
        755                 760                 765             


Leu Ala Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr 
    770                 775                 780                 


Leu Cys Glu Leu Cys Asp Lys Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Arg Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810                 815     


Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val Val 
            820                 825                 830         


Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser Tyr 
        835                 840                 845             


Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg Glu 
    850                 855                 860                 


Asn Asp Thr Lys Gln Glu Glu Lys Ile Lys Tyr Glu Asp Asp Leu Leu 
865                 870                 875                 880 


Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser Pro 
                885                 890                 895     


Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln Leu 
            900                 905                 910         


Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920         


<210>  3305
<211>  923
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3305

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Val Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Glu Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asn Ser Ser Asn Ile Glu Leu Arg Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Gly Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu His Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Asp Asp Tyr 
            340                 345                 350         


Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys 
        355                 360                 365             


Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met 
    370                 375                 380                 


Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val 
385                 390                 395                 400 


Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr 
                405                 410                 415     


Tyr Arg Asn Asp Val Ile Ala Gly Glu Ala Leu Val Arg Lys Leu Arg 
            420                 425                 430         


Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala 
        435                 440                 445             


Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp 
    450                 455                 460                 


His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp 
465                 470                 475                 480 


Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu 
                485                 490                 495     


Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly 
            500                 505                 510         


Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn 
        515                 520                 525             


Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu 
    530                 535                 540                 


Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile 
545                 550                 555                 560 


Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro 
                565                 570                 575     


Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu 
            580                 585                 590         


Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys 
        595                 600                 605             


Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr 
    610                 615                 620                 


Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala 
625                 630                 635                 640 


Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met 
                645                 650                 655     


Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys 
            660                 665                 670         


Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg 
        675                 680                 685             


Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys 
    690                 695                 700                 


Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg 
705                 710                 715                 720 


Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val 
                725                 730                 735     


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys 
            740                 745                 750         


Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala 
        755                 760                 765             


Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys 
    770                 775                 780                 


Glu Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys 
785                 790                 795                 800 


Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp 
                805                 810                 815     


Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val 
            820                 825                 830         


Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser 
        835                 840                 845             


Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg 
    850                 855                 860                 


Glu Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu 
865                 870                 875                 880 


Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser 
                885                 890                 895     


Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln 
            900                 905                 910         


Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920             


<210>  3306
<211>  923
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3306

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Val Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Glu Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asn Ser Ser Asn Ile Glu Leu Arg Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Gly Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu His Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Asp Asp Tyr 
            340                 345                 350         


Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys 
        355                 360                 365             


Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met 
    370                 375                 380                 


Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val 
385                 390                 395                 400 


Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr 
                405                 410                 415     


Tyr Arg Asn Asp Val Ile Ala Gly Glu Ala Leu Val Arg Lys Leu Arg 
            420                 425                 430         


Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala 
        435                 440                 445             


Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp 
    450                 455                 460                 


His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp 
465                 470                 475                 480 


Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu 
                485                 490                 495     


Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly 
            500                 505                 510         


Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn 
        515                 520                 525             


Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu 
    530                 535                 540                 


Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile 
545                 550                 555                 560 


Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro 
                565                 570                 575     


Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu 
            580                 585                 590         


Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys 
        595                 600                 605             


Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr 
    610                 615                 620                 


Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala 
625                 630                 635                 640 


Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met 
                645                 650                 655     


Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys 
            660                 665                 670         


Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg 
        675                 680                 685             


Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys 
    690                 695                 700                 


Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg 
705                 710                 715                 720 


Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val 
                725                 730                 735     


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys 
            740                 745                 750         


Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala 
        755                 760                 765             


Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys 
    770                 775                 780                 


Glu Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys 
785                 790                 795                 800 


Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp 
                805                 810                 815     


Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val 
            820                 825                 830         


Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser 
        835                 840                 845             


Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg 
    850                 855                 860                 


Glu Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu 
865                 870                 875                 880 


Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser 
                885                 890                 895     


Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln 
            900                 905                 910         


Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920             


<210>  3307
<211>  923
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3307

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Val Glu Ile Asn Asn Asn Ala Val 
            20                  25                  30          


Pro Glu Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Val Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Lys Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asn Ser Ser Asn Ile Glu Leu Arg Gly Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Trp Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Ile Lys Gly Ser Glu Ser Tyr Asp Asp 
        195                 200                 205             


Phe Met Gly Tyr Leu Ser Ala Arg Asn Thr Tyr Glu Val Phe Thr His 
    210                 215                 220                 


Pro Asp Lys Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Ser Val Phe His Asp Lys Ser Ser Lys Leu His Glu Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asp Ile Ile Asp Ser Glu Tyr Arg Glu Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Asp Glu Arg Phe Asp Ser Ile Asn Lys Gly Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Asp Asp Tyr 
            340                 345                 350         


Glu Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys 
        355                 360                 365             


Ser Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met 
    370                 375                 380                 


Leu Asp Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val 
385                 390                 395                 400 


Arg Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr 
                405                 410                 415     


Tyr Arg Asn Asp Val Ile Ala Gly Glu Ala Leu Val Arg Lys Leu Arg 
            420                 425                 430         


Phe Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala 
        435                 440                 445             


Ala Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp 
    450                 455                 460                 


His Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp 
465                 470                 475                 480 


Phe Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu 
                485                 490                 495     


Leu Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly 
            500                 505                 510         


Lys Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn 
        515                 520                 525             


Ile Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu 
    530                 535                 540                 


Cys Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile 
545                 550                 555                 560 


Thr Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro 
                565                 570                 575     


Ala Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu 
            580                 585                 590         


Gly Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys 
        595                 600                 605             


Leu Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr 
    610                 615                 620                 


Asn Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala 
625                 630                 635                 640 


Asn Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met 
                645                 650                 655     


Phe Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys 
            660                 665                 670         


Ser Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg 
        675                 680                 685             


Ser Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys 
    690                 695                 700                 


Asn Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg 
705                 710                 715                 720 


Ala Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val 
                725                 730                 735     


Lys Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys 
            740                 745                 750         


Leu Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala 
        755                 760                 765             


Ser Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys 
    770                 775                 780                 


Glu Leu Cys Asp Asn Gly Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys 
785                 790                 795                 800 


Asn Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp 
                805                 810                 815     


Ser Ser Met Thr Arg Lys Tyr Arg Asn Cys Ile Ala His Leu Thr Val 
            820                 825                 830         


Val Arg Glu Leu Lys Glu Tyr Ile Gly Asp Ile Arg Thr Val Asp Ser 
        835                 840                 845             


Tyr Phe Ser Ile Tyr His Tyr Val Met Gln Arg Cys Ile Thr Lys Arg 
    850                 855                 860                 


Glu Asn Asp Thr Lys Gln Glu Asp Lys Ile Lys Tyr Glu Asp Asp Leu 
865                 870                 875                 880 


Leu Lys Asn His Gly Tyr Thr Lys Asp Phe Val Lys Ala Leu Asn Ser 
                885                 890                 895     


Pro Phe Gly Tyr Asn Ile Pro Arg Phe Lys Asn Leu Ser Ile Glu Gln 
            900                 905                 910         


Leu Phe Asp Arg Asn Glu Tyr Leu Thr Glu Lys 
        915                 920             


<210>  3308
<211>  922
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic

<400>  3308

Met Ala Lys Lys Asn Lys Met Lys Pro Arg Glu Leu Arg Glu Ala Gln 
1               5                   10                  15      


Lys Lys Ala Arg Gln Leu Lys Ala Ala Glu Ile Asn Asn Asn Ala Ala 
            20                  25                  30          


Pro Ala Ile Ala Ala Met Pro Ala Ala Glu Val Ile Ala Pro Ala Ala 
        35                  40                  45              


Glu Lys Lys Lys Ser Ser Val Lys Ala Ala Gly Met Lys Ser Ile Leu 
    50                  55                  60                  


Val Ser Glu Asn Lys Met Tyr Ile Thr Ser Phe Gly Lys Gly Asn Ser 
65                  70                  75                  80  


Ala Val Leu Glu Tyr Glu Val Asp Asn Asn Asp Tyr Asn Gln Thr Gln 
                85                  90                  95      


Leu Ser Ser Lys Asp Asn Ser Asn Ile Glu Leu Gly Asp Val Asn Glu 
            100                 105                 110         


Val Asn Ile Thr Phe Ser Ser Lys His Gly Phe Glu Ser Gly Val Glu 
        115                 120                 125             


Ile Asn Thr Ser Asn Pro Thr His Arg Ser Gly Glu Ser Ser Pro Val 
    130                 135                 140                 


Arg Gly Asp Met Leu Gly Leu Lys Ser Glu Leu Glu Lys Arg Phe Phe 
145                 150                 155                 160 


Gly Lys Thr Phe Asp Asp Asn Ile His Ile Gln Leu Ile Tyr Asn Ile 
                165                 170                 175     


Leu Asp Ile Glu Lys Ile Leu Ala Val Tyr Val Thr Asn Ile Val Tyr 
            180                 185                 190         


Ala Leu Asn Asn Met Leu Gly Val Lys Gly Ser Glu Ser His Asp Asp 
        195                 200                 205             


Phe Ile Gly Tyr Leu Ser Thr Asn Asn Thr Tyr Asp Val Phe Ile Asp 
    210                 215                 220                 


Pro Asp Asn Ser Ser Leu Ser Asp Asp Lys Lys Ala Asn Val Arg Lys 
225                 230                 235                 240 


Ser Leu Ser Lys Phe Asn Val Leu Leu Lys Thr Lys Arg Leu Gly Tyr 
                245                 250                 255     


Phe Gly Leu Glu Glu Pro Lys Thr Lys Asp Thr Arg Val Ser Gln Ala 
            260                 265                 270         


Tyr Lys Lys Arg Val Tyr His Met Leu Ala Ile Val Gly Gln Ile Arg 
        275                 280                 285             


Gln Cys Val Phe His Asp Lys Ser Gly Ala Lys Arg Phe Asp Leu Tyr 
    290                 295                 300                 


Ser Phe Ile Asn Asn Ile Asp Pro Glu Tyr Arg Asp Thr Leu Asp Tyr 
305                 310                 315                 320 


Leu Val Glu Glu Arg Leu Lys Ser Ile Asn Lys Asp Phe Ile Gln Gly 
                325                 330                 335     


Asn Lys Val Asn Ile Ser Leu Leu Ile Asp Met Met Lys Gly Tyr Glu 
            340                 345                 350         


Ala Asp Asp Ile Ile Arg Leu Tyr Tyr Asp Phe Ile Val Leu Lys Ser 
        355                 360                 365             


Gln Lys Asn Leu Gly Phe Ser Ile Lys Lys Leu Arg Glu Lys Met Leu 
    370                 375                 380                 


Glu Glu Tyr Gly Phe Arg Phe Lys Asp Lys Gln Tyr Asp Ser Val Arg 
385                 390                 395                 400 


Ser Lys Met Tyr Lys Leu Met Asp Phe Leu Leu Phe Cys Asn Tyr Tyr 
                405                 410                 415     


Arg Asn Asp Val Val Ala Gly Glu Ala Leu Val Arg Lys Leu Arg Phe 
            420                 425                 430         


Ser Met Thr Asp Asp Glu Lys Glu Gly Ile Tyr Ala Asp Glu Ala Ala 
        435                 440                 445             


Lys Leu Trp Gly Lys Phe Arg Asn Asp Phe Glu Asn Ile Ala Asp His 
    450                 455                 460                 


Met Asn Gly Asp Val Ile Lys Glu Leu Gly Lys Ala Asp Met Asp Phe 
465                 470                 475                 480 


Asp Glu Lys Ile Leu Asp Ser Glu Lys Lys Asn Ala Ser Asp Leu Leu 
                485                 490                 495     


Tyr Phe Ser Lys Met Ile Tyr Met Leu Thr Tyr Phe Leu Asp Gly Lys 
            500                 505                 510         


Glu Ile Asn Asp Leu Leu Thr Thr Leu Ile Ser Lys Phe Asp Asn Ile 
        515                 520                 525             


Lys Glu Phe Leu Lys Ile Met Lys Ser Ser Ala Val Asp Val Glu Cys 
    530                 535                 540                 


Glu Leu Thr Ala Gly Tyr Lys Leu Phe Asn Asp Ser Gln Arg Ile Thr 
545                 550                 555                 560 


Asn Glu Leu Phe Ile Val Lys Asn Ile Ala Ser Met Arg Lys Pro Ala 
                565                 570                 575     


Ala Ser Ala Lys Leu Thr Met Phe Arg Asp Ala Leu Thr Ile Leu Gly 
            580                 585                 590         


Ile Asp Asp Asn Ile Thr Asp Asp Arg Ile Ser Glu Ile Leu Lys Leu 
        595                 600                 605             


Lys Glu Lys Gly Lys Gly Ile His Gly Leu Arg Asn Phe Ile Thr Asn 
    610                 615                 620                 


Asn Val Ile Glu Ser Ser Arg Phe Val Tyr Leu Ile Lys Tyr Ala Asn 
625                 630                 635                 640 


Ala Gln Lys Ile Arg Glu Val Ala Lys Asn Glu Lys Val Val Met Phe 
                645                 650                 655     


Val Leu Gly Gly Ile Pro Asp Thr Gln Ile Glu Arg Tyr Tyr Lys Ser 
            660                 665                 670         


Cys Val Glu Phe Pro Asp Met Asn Ser Ser Leu Glu Ala Lys Arg Ser 
        675                 680                 685             


Glu Leu Ala Arg Met Ile Lys Asn Ile Ser Phe Asp Asp Phe Lys Asn 
    690                 695                 700                 


Val Lys Gln Gln Ala Lys Gly Arg Glu Asn Val Ala Lys Glu Arg Ala 
705                 710                 715                 720 


Lys Ala Val Ile Gly Leu Tyr Leu Thr Val Met Tyr Leu Leu Val Lys 
                725                 730                 735     


Asn Leu Val Asn Val Asn Ala Arg Tyr Val Ile Ala Ile His Cys Leu 
            740                 745                 750         


Glu Arg Asp Phe Gly Leu Tyr Lys Glu Ile Ile Pro Glu Leu Ala Ser 
        755                 760                 765             


Lys Asn Leu Lys Asn Asp Tyr Arg Ile Leu Ser Gln Thr Leu Cys Glu 
    770                 775                 780                 


Leu Cys Asp Asp Arg Asp Glu Ser Pro Asn Leu Phe Leu Lys Lys Asn 
785                 790                 795                 800 


Lys Arg Leu Arg Lys Cys Val Glu Val Asp Ile Asn Asn Ala Asp Ser 
                805                 810     